bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stress field in northeastern Japan and its relationship with faults of recent earthquakes
Authors: Tagami Ayaka , Matsuno Miu , Okada Tomomi , Sakai Shin’ichi , Ohzono Mako , Katsumata Kei , Kosuga Masahiro , Yamanaka Yoshiko , Katao Hiroshi , Matsushima Takeshi , Yakiwara Hiroshi , Hirahara Satoshi , Kono Toshio , Hori Shu’ichiro , Matsuzawa Toru , Kimura Shuutoku , Nakayama Takashi ,   Group for the aftershock observations of the 2011 off the Pacific coast of Tohoku Earthquake
Published: March 2024

AbstractInversion tectonics, in which old normal faults act as reverse faults in current stress fields, are frequently observed in northeastern Japan (Tohoku District); however, the conditions that control these fault activities remain unclear. To improve the identification of faults that are more favorable to slip under current stress conditions, the regional fault mechanisms in the Tohoku District must be better understood. The stress field in the Tohoku District and the likelihood of fault activities were thus estimated using slip tendency (ST) analysis. The results show that in the eastern margin of the Japan Sea (EMJS), the reverse fault type is dominant in the stress field. The maximum horizontal direction changes clockwise from E–W to NW–SE from the northern to the southern regions and counterclockwise from NW–SE to E–W from the Japan Sea to the inland area. In the Tohoku inland area, the estimated direction of the maximum horizontal axis changed after the 2011 Tohoku-Oki earthquake, from E–W to WNW–ESE. ST values were calculated for seven events in the EMJS area. To avoid the influence of the Tohoku-Oki earthquake, only stress field data prior to the 2011 Tohoku-Oki earthquake were used to determine ST values for four of the events in the Tohoku inland area. The results showed eastward-dipping fault planes with low dip angles (approximately 30°–45°) and large ST values (approximately > 0.7). The large ST values indicate that the stress field fault is favorable to slip and the results were consistent with the actual fault plane in the EMJS area. However, in the Tohoku inland area and the southern part of fault model of the 1993 Hokkaido Nansei-Oki earthquake, fault planes with large ST values were found to be inconsistent with the slipped fault plane, thus indicating that slipping was unfavorable. The regional differences are consistent with the volcano distribution and thus, the fluid supply from volcanic activity may have helped the fault slip under difficult stress conditions.
Graphical Abstract
Assessment of forest fire severity and land surface temperature using Google Earth Engine: a case study of Gujarat State, India
Authors: Jodhani Keval H. , Patel Haard , Soni Utsav , Patel Rishabh , Valodara Bhairavi , Gupta Nitesh , Patel Anant , Omar Padam jee 
Published: March 2024

AbstractForest fires are a recurring issue in many parts of the world, including India. These fires can have various causes, including human activities (such as agricultural burning, campfires, or discarded cigarettes) and natural factors (such as lightning). The present study presents a comprehensive and advanced methodology for assessing wildfire susceptibility by integrating diverse environmental variables and leveraging cutting-edge machine learning techniques across Gujarat State, India. The primary goal of the study is to utilize Google Earth Engine to compare locations in Gujarat, India, before and after forest fires. High-resolution satellite data were used to assess the amount and types of changes caused by forest fires. The present study meticulously analyzes various environmental variables, i.e., slope orientation, elevation, normalized difference vegetation index (NDVI), drainage density, precipitation, and temperature to understand landscape characteristics and assess wildfire susceptibility. In addition, a sophisticated random forest regression model is used to predict land surface temperature based on a set of environmental parameters. The maps that result depict the geographical distribution of normalized burn ratio and difference normalized burn ratio and land surface temperature forecasts, providing valuable insights into spatial patterns and trends. The findings of this work show that an automated temporal analysis utilizing Google Earth Engine may be used successfully over a wide range of land cover types, providing critical data for future monitoring of such threats. The impact of forest fires can be severe, leading to the loss of biodiversity, damage to ecosystems, and threats to human settlements.
Novel Functional Radiomics for Prediction of Cardiac Positron Emission Tomography Avidity in Lung Cancer Radiotherapy
Authors: Choi Wookjin , Jia Yingcui , Kwak Jennifer , Werner-Wasik Maria , Dicker Adam P. , Simone Nicole L. , Storozynsky Eugene , Jain Varsha , Vinogradskiy Yevgeniy 
Published: March 2024

PURPOSE Traditional methods of evaluating cardiotoxicity focus on radiation doses to the heart. Functional imaging has the potential to provide improved prediction for cardiotoxicity for patients with lung cancer. Fluorine-18 (18F) fluorodeoxyglucose (FDG)-positron emission tomography (PET)/computed tomography (CT) imaging is routinely obtained in a standard cancer staging workup. This work aimed to develop a radiomics model predicting clinical cardiac assessment using 18F-FDG PET/CT scans before thoracic radiation therapy. METHODS Pretreatment 18F-FDG PET/CT scans from three study populations (N = 100, N = 39, N = 70) were used, comprising two single-institutional protocols and one publicly available data set. A clinician (V.J.) classified the PET/CT scans per clinical cardiac guidelines as no uptake, diffuse uptake, or focal uptake. The heart was delineated, and 210 novel functional radiomics features were selected to classify cardiac FDG uptake patterns. Training data were divided into training (80%)/validation (20%) sets. Feature reduction was performed using the Wilcoxon test, hierarchical clustering, and recursive feature elimination. Ten-fold cross-validation was carried out for training, and the accuracy of the models to predict clinical cardiac assessment was reported. RESULTS From 202 of 209 scans, cardiac FDG uptake was scored as no uptake (39.6%), diffuse uptake (25.3%), and focal uptake (35.1%), respectively. Sixty-two independent radiomics features were reduced to nine clinically pertinent features. The best model showed 93% predictive accuracy in the training data set and 80% and 92% predictive accuracy in two external validation data sets. CONCLUSION This work used an extensive patient data set to develop a functional cardiac radiomic model from standard-of-care 18F-FDG PET/CT scans, showing good predictive accuracy. The radiomics model has the potential to provide an automated method to predict existing cardiac conditions and provide an early functional biomarker to identify patients at risk of developing cardiac complications after radiotherapy.
The impact of preferential selection mechanism based on average payoff and stability of payoff on the evolution of cooperation
Authors: Li Pengcheng , Ye Tianbo , Fan Suohai 
Published: March 2024

Abstract
Recent studies on memory-based cooperative evolution have focused on random selection of learning objects and only considered average payoff, neglecting stability of payoff. Here, we propose a preference selection mechanism adopting the TOPSIS method, a multi-attribute decision-making approach. We introduce the weighting factors ω
1 and ω
2, which refer to average payoff and stability of payoff, respectively. The probability that an individual select his neighbor is influenced by both average payoff and stability. We investigate the effect of memory length M and ω
1 on the evolution of cooperation. The simulation results indicate that M and ω
1 can both somewhat promote cooperation. Given that

, for small betrayal temptation b, cooperation is more robust for small M, while for large b, large values of M are preferred. Further exploring the impact of ω
1, for relatively small b, the influence of ω
1 on cooperation is gradually revealed and strengthened as M increases. Conversely, for relatively large b, the impact of ω
1 on cooperation slowly diminishes from strong as M increase, reflecting a gradual rise in the importance of stability. These findings enhance the understanding of cooperative behavior in real social environments and make more rational decisions under the multi-factor evaluation based on average payoff and stability.
An Open-label Phase 2 Study of Eneboparatide, a Novel PTH Receptor 1 Agonist, in Hypoparathyroidism
Authors: Takacs Istvan , Mezosi Emese , Soto Alfonso , Kamenický Peter , Figueres Lucile , Galvez Moreno Maria Angeles , Lemoine Sandrine , Borson-Chazot Francoise , Capel Ismael , Ouldrouis Taha , Lucas Nadège , Allas Soraya , Sumeray Mark , Ovize Michel , Mannstadt Michael 
Published: March 2024

Abstract

Context
Hypoparathyroidism is a rare disorder characterized by a deficiency in PTH resulting in hypocalcemia, hyperphosphatemia, and hypercalciuria. Eneboparatide is an investigational peptide agonist of the PTH1 receptor for the treatment of chronic hypoparathyroidism (HP).

Objective
To evaluate the efficacy, safety, and tolerability of eneboparatide in HP patients.

Design
Open-label, phase 2 study.

Participants
Twenty-eight patients (21 women, 7 men), mean age (range): 58 years (28-72), with HP were enrolled into 2 consecutive cohorts (C1, n = 12 and C2, n = 16).

Intervention
Following an optimization period, daily subcutaneous injections of eneboparatide were administered for 3 months at a 20 µg/day (C1) or 10 µg/day (C2) starting dose. Conventional therapy was progressively removed, and eneboparatide could be titrated up to 60 µg (C1) or 80 µg (C2).

Main outcomes
Proportion of patients achieving independence from conventional therapy, albumin-adjusted serum calcium (ADsCa), 24-h urine calcium (uCa), serum bone turnover markers (serum carboxy-terminal telopeptide of type I collagen and procollagen 1 intact N-terminal propeptide), bone mineral density (BMD), and adverse events (AEs).

Results
After 3 months, ≥ 88% of patients achieved independence from conventional therapy while mean ADsCa was maintained within target range (7.8-9 mg/dL). Eneboparatide induced a rapid and sustained reduction of mean 24-hour uCa, even among patients with hypercalciuria. Bone turnover markers slightly increased, and BMD remained unchanged, consistent with progressive resumption of physiologic bone turnover. Eneboparatide was well tolerated with no serious AEs.

Conclusion
Eneboparatide allowed independence from conventional therapy and maintenance of serum calcium within a target range while normalizing uCa excretion and producing a balanced resumption of bone turnover.
The Spectrum of Dysregulated Aldosterone Production: An International Human Physiology Study
Authors: Parksook Wasita W , Brown Jenifer M , Omata Kei , Tezuka Yuta , Ono Yoshikiyo , Satoh Fumitoshi , Tsai Laura C , Niebuhr Yvonne , Milks Julia , Moore Anna , Honzel Brooke , Liu Haiping , Auchus Richard J , Sunthornyothin Sarat , Turcu Adina F , Vaidya Anand 
Published: March 2024

Abstract

Context
Primary aldosteronism is a form of low-renin hypertension characterized by dysregulated aldosterone production.

Objective
To investigate the contributions of renin-independent aldosteronism and ACTH-mediated aldosteronism in individuals with a low-renin phenotype representing the entire continuum of blood pressure.

Design/Participants
Human physiology study of 348 participants with a low-renin phenotype with severe and/or resistant hypertension, hypertension with hypokalemia, elevated blood pressure and stage I/II hypertension, and normal blood pressure.

Setting
4 international centers.

Interventions/Main Outcome Measures
The saline suppression test (SST) to quantify the magnitude of renin-independent aldosteronism; dexamethasone suppression and ACTH-stimulation tests to quantify the magnitude of ACTH-mediated aldosteronism; adrenal venous sampling to determine lateralization.

Results
There was a continuum of nonsuppressible and renin-independent aldosterone production following SST that paralleled the magnitude of the blood pressure continuum and transcended conventional diagnostic thresholds. In parallel, there was a full continuum of ACTH-mediated aldosteronism wherein post-SST aldosterone levels were strongly correlated with ACTH-stimulated aldosterone production (r = 0.75, P &lt; .0001) and nonsuppressible aldosterone production postdexamethasone (r = 0.40, P &lt; .0001). Beyond participants who met the criteria for primary aldosteronism (post-SST aldosterone of ≥10 ng/dL or ≥277 pmol/L), the continuum of nonsuppressible and renin-independent aldosterone production persisted below this diagnostic threshold, wherein 15% still had lateralizing aldosteronism amenable to surgical adrenalectomy and the remainder were treated with mineralocorticoid receptor antagonists.

Conclusion
In the context of a low-renin phenotype, there is a continuum of primary aldosteronism and dysregulated aldosterone production that is prominently influenced by ACTH. A large proportion of individuals with low renin may benefit from aldosterone-directed therapy.
How is prenatal stress transmitted from the mother to the fetus?
Authors: Sze Ying , Brunton Paula J. 
Published: March 2024

ABSTRACT
Prenatal stress programmes long-lasting neuroendocrine and behavioural changes in the offspring. Often this programming is maladaptive and sex specific. For example, using a rat model of maternal social stress in late pregnancy, we have demonstrated that adult prenatally stressed male, but not prenatally stressed female offspring display heightened anxiety-like behaviour, whereas both sexes show hyperactive hypothalamo–pituitary–adrenal (HPA) axis responses to stress. Here, we review the current knowledge of the mechanisms underpinning dysregulated HPA axis responses, including evidence supporting a role for reduced neurosteroid-mediated GABAergic inhibitory signalling in the brains of prenatally stressed offspring. How maternal psychosocial stress is signalled from the mother to the fetuses is unclear. Direct transfer of maternal glucocorticoids to the fetuses is often considered to mediate the programming effects of maternal stress on the offspring. However, protective mechanisms including attenuated maternal stress responses and placental 11β-hydroxysteroid dehydrogenase-2 (which inactivates glucocorticoids) should limit materno-fetal glucocorticoid transfer during pregnancy. Moreover, a lack of correlation between maternal stress, circulating maternal glucocorticoid levels and circulating fetal glucocorticoid levels is reported in several studies and across different species. Therefore, here we interrogate the evidence for a role for maternal glucocorticoids in mediating the effects of maternal stress on the offspring and consider the evidence for alternative mechanisms, including an indirect role for glucocorticoids and the contribution of changes in the placenta in signalling the stress status of the mother to the fetus.
Experimental biology can inform our understanding of food insecurity
Authors: Wilbrecht Linda , Lin Wan Chen , Callahan Kathryn , Bateson Melissa , Myers Kevin , Ross Rachel 
Published: March 2024

ABSTRACT
Food insecurity is a major public health issue. Millions of households worldwide have intermittent and unpredictable access to food and this experience is associated with greater risk for a host of negative health outcomes. While food insecurity is a contemporary concern, we can understand its effects better if we acknowledge that there are ancient biological programs that evolved to respond to the experience of food scarcity and uncertainty, and they may be particularly sensitive to food insecurity during development. Support for this conjecture comes from common findings in several recent animal studies that have modeled insecurity by manipulating predictability of food access in various ways. Using different experimental paradigms in different species, these studies have shown that experience of insecure access to food can lead to changes in weight, motivation and cognition. Some of these studies account for changes in weight through changes in metabolism, while others observe increases in feeding and motivation to work for food. It has been proposed that weight gain is an adaptive response to the experience of food insecurity as ‘insurance’ in an uncertain future, while changes in motivation and cognition may reflect strategic adjustments in foraging behavior. Animal studies also offer the opportunity to make in-depth controlled studies of mechanisms and behavior. So far, there is evidence that the experience of food insecurity can impact metabolic efficiency, reproductive capacity and dopamine neuron synapses. Further work on behavior, the central and peripheral nervous system, the gut and liver, along with variation in age of exposure, will be needed to better understand the full body impacts of food insecurity at different stages of development.
Artificial dermis combined with negative pressure wound therapy and platelet-rich plasma to treat traumatic wounds: a retrospective study
Authors: Zhu Jin , Yan Li , Hu Rui , Yang Chunbao , Wu Mingzheng , An Ying , Li Shanqing 
Published: March 2024

Objective: The reconstruction of complex soft tissue defects with exposure of bones and tendons represents an increasing challenge in wound care, especially in large extremity wounds. The aim of this study was to detect the clinical efficacy of combined use of negative pressure wound therapy (NPWT), artificial dermis (ADM), platelet-rich plasma (PRP) and split-thickness skin grafting (STSG) in the reconstruction of large traumatic extremity skin defects. Method: In this study, eight cases were treated with combined therapies for repairing complex extremity wounds and the results were reviewed retrospectively. After surgical debridement, all wounds received ADM, PRP and delayed STSG, which were all aided with NPWT. Results: The patients consisted of five males and three females, with a mean age of 44 years. A total of six lower extremity wounds were located at the foot/ankle, with exposed tendon in five, bone exposure in three and both in two. Of the group, two patients had exposed tendon on arm/hand wounds. The size of wounds and ADM averaged 126cm2 and 42.3cm2, respectively. ADM was used to cover the exposed bone or tendon, the granulation and muscular tissue were covered with vacuum sealing drainage (VSD) directly, for NPWT. The survival rate of ADM averaged 98.9%. The average time for survival of ADM was 12.8 days and the mean uptake of autologous skin graft was 93.5%. Only one patient received repeated skin grafts. All patients achieved successful healing and reported no complications. The mean length of hospital stay was 36.1 days. Conclusion: Our study revealed that ADM in conjunction with NPWT, PRP and STSG could be used for repairing large traumatic extremity wounds. Wound closure was achieved without flaps, the aesthetic and functional outcomes were acceptable, and only one patient developed a 35% loss of skin graft. Declaration of interest: This work was supported by grants from the Natural Science Foundation of Hubei Province (grant no. 2020CFB464) and Youth Foundation of Wuhan Municipal Health Commission (grant no. WX20Q15). The authors have no conflicts of interest to declare.
Cholangiohydatidosis. Clinical features, postoperative complications and hospital mortality. A systematic review
Authors: Manterola Carlos , Rivadeneira Josue , Rojas-Pincheira Claudio , Otzen Tamara , Delgado Hugo , Sotelo Catalina , Sanhueza Antonio 
Published: March 2024

Background
Cholangiohydatidosis (CH) is an evolutionary complication of hepatic cystic echinococcosis, associated with increased morbidity and mortality. The aim of this study was to describe the available evidence regarding clinical characteristics of CH, postoperative complications and hospital mortality.

Methodology/Principal findings
Systematic review. Studies related to CH with no language or publication restriction were included. Sensitive searches were performed in Trip Database, SciELO, BIREME-BVS, WoS, PubMed, EMBASE and SCOPUS. MeSH and free terms were used, including articles up to April 2023. The main outcome variables were postoperative complications and hospital mortality; the secondary ones were publication year, origin and design of primary studies, main clinical manifestation, anatomical location and type of cysts, hospital stay, surgical procedure performed, reinterventions; and methodological quality of primary studies, which was assessed using MInCir-T and MInCir-P scales. Descriptive statistics, calculation of weighted averages and their comparison by least squares logistic regression were applied. 446 studies were retrieved from the searches performed, 102 of which met the inclusion and exclusion criteria. The studies analyzed represent 1241 patients. The highest proportion of articles was published in the last decade (39.2%). Reports are mainly from Turkey (28.4%), Greece (9.8%), Morocco and Spain (8.8% each). With a weighted mean of 14.3 days of hospital stance; it was verified that 26.2% of patients developed postoperative complications (74,3% Clavien y Dindo III y IV), 6.7% needed re-interventions, and 3.7% died. When comparing the variables age, postoperative complications, hospital mortality, and reinterventions in two periods of time (1982–2006 vs. 2007–2023), no statistically significant differences were found. When applying the MInCir-T and MInCir-P scales, the methodological quality of the primary studies was 9.6±1.1 and 14.5±4.3 points, respectively.

Conclusion/Significance
CH is associated with severe postoperative complications and significant hospital mortality, independent of the development of therapeutic support associated with the passage of time.
Prevalence of depressive symptoms in patients with advanced schistosomiasis in China: A systematic review and meta-analysis
Authors: Qi Yu-Xin , Huang Meng-Rui , Sun Hui-Ying , Wu Xiao-Yan , Liu Ze-Ting , Lu Da-Bing 
Published: March 2024

Background
Advanced schistosomiasis is the most serious outcome of infection and has a negative impact on both physical fitness and mental health of patients, the latter of which has long been overlooked. Therefore, we performed this systematic review and meta-analysis to estimate the overall prevalence of depressive symptoms, one of the most common mental problems, in patients with advanced schistosomiasis in China.

Methods
Six electronic databases were searched for studies reporting the prevalence of depressive symptoms in the targeted patients. Assessments were pooled using a fixed- or random-effects model based on heterogeneity test. Subgroup analyses were further performed and differences between/among groups were examined using the chi-squared test. The protocol had previously been registered in PROSPERO (CRD42023406708).

Results
A total of 11 studies with 1,673 participants were included. The pooled prevalence of depressive symptoms in advanced schistosomiasis in China was 62.01% (95% CI: 51.30% - 72.72%), with a significant heterogeneity among studies. Depressive symptoms were more prevalent in patients with complications and more than half of the patients suffered a mild- or moderate-level of depression. No publication bias was found, and sensitivity analysis showed a stable result.

Conclusions
The overall prevalence of depressive symptoms in advanced schistosomiasis in China was high enough to warrant psychotherapeutic interventions, especially for patients with complications. This would greatly prevent or/and reduce depression and improve their quality of life.