bluuebunny/crossref_metadata_2025_split huggingface dataset:
Point‐of‐care Urine Trypsinogen Testing for the Diagnosis of Pancreatitis
Authors: Jang Timothy , Uzbielo Alison , Sineff Sanford , Naunheim Rosanne , Scott Mitchell G. , Lewis Lawrence M. 
Published: November 2006

Abstract Objectives To assess a point‐of‐care (POC) urine trypsinogen (UT) test for the diagnosis of pancreatitis in the emergency department (ED). Methods This was a prospective cohort study of a convenience sample of patients presenting to the ED with abdominal pain or symptoms suggestive of pancreatitis. A 3‐minute POC UT test (Actim Pancreatitis; Medix Biochemica, Kauniainen, Finland) was compared with plasma lipase and amylase measurements, imaging results when performed, and final discharge diagnoses. The criterion standard was a final discharge diagnosis of acute pancreatitis. Results Of 191 patients included in this study, 17 patients were diagnosed with either acute or acute‐on‐chronic pancreatitis. The sensitivity and specificity of UT for acute pancreatitis were, respectively, 100% (95% confidence interval [CI] = 77% to 100%) and 96% (95% CI = 92% to 98%). Seven of the 17 patients with pancreatitis (41%) had diagnostic findings on CT and positive UT tests but had nondiagnostic plasma lipase and amylase levels. Conclusions A POC UT screening test for pancreatitis in the ED compared favorably with plasma lipase and amylase levels. Future studies should be performed to explore whether this test in the ED setting has better clinical utility than plasma lipase or amylase.
Patient reciprocity and physician burnout: what do patients bring to the patient-physician relationship?
Authors: Halbesleben Jonathon R B 
Published: November 2006

Despite its criticality to the provision of health care, little is known about how the patient-physician relationship influences burnout. This article seeks to understand how patient performance (e.g. being informative about needs) during office visits is associated with perceived reciprocity in the patient-physician relationship, which is in turn associated with physician burnout. To that end, we report the results of a cross-sectional survey of 252 matched pairs of patients and their primary care physicians about a recent office visit. The findings support a social exchange model of burnout that suggests that patient stressors and patient performance predict perceived reciprocity and subsequent burnout. Interestingly, patients' perceptions of their performance differed from physicians' perceptions; physicians' perceptions of performance fit the social exchange model better than patients' perceptions of performance. The present work suggests that while they are a source of demands, patients also provide resources that are critical to the patient-physician relationship. To the extent that we can encourage these resources, we can improve perceived reciprocity and reduce burnout in physicians.
The -spectrum of a linear order
Authors: Miller Russell 
Published: November 2006

AbstractSlaman and Wehner have constructed structures which distinguish the computable Turing degree 0 from the noncomputable degrees, in the sense that the spectrum of each structure consists precisely of the noncomputable degrees. Downey has asked if this can be done for an ordinary type of structure such as a linear order. We show that there exists a linear order whose spectrum includes every noncomputable degree, but not 0. Since our argument requires the technique of permitting below a set, we include a detailed explantion of the mechanics and intuition behind this type of permitting.
On the possible significance of the quadratic effect of age on lung‐function measurements
Authors: Schulzer Michael , Chan‐Yeung Moira , Tan Felisa 
Published: November 2006

AbstractThe problem of interpreting lung‐function measurements in industrial workers is examined. Two common lung‐function measurements (FEV1, and FVC) are described. The standard method currently used in the analysis of such cross‐sectional survey data is discussed. The basic assumption of a linear decline with age is questioned on the basis of large sets of data from a variety of industries in British Columbia. It is shown that, while the linear assumption holds approximately in unexposed. healthy nonsmoking individuals, a quadratic age effect is often observed in smokers and/or in individuals who are industrially exposed to certain fumes or dusts. Recognizing this accelerated rate of deterioration in the lungs is of fundamental importance both to the identification of affected individuals and to the understanding of the process involved. An attempt is made to interpret the variety of nonlinear situations observed, by appealing to population selection mechanisms, individual variations in susceptibility, and the effects due to various levels of stimulus strength.
Limit expressions for the risk of james‐stein estimators
Authors: Casella George , Hwang Jiunn Tzon 
Published: November 2006

AbstractLimit expressions (as the dimension p ← ∞ ) are derived for the relative risk of the James‐Stein estimator and its positive‐part version. The limit is simple to evaluate, and gives the amount of improvement in risk that is possible. The technique used is to bound the risk, both above and below. with bounds that converge to the same limit. For the James‐Stein estimator these bounds are simple to calculate, and are quite accurate even for moderate dimensions.
Grendel and Grep
Authors: Malone Kemp 
Published: November 2006

The Gesta Danorum of the twelfth-century Danish historian, Saxo Grammaticus, might fairly be expected to include stories corresponding, more or less, to those episodes of Beowulf the scene of which was the Danish court; in point of fact the Ingeld episode, at least, was known to Saxo, who gives us two versions of it, differing widely, it is true, from each other and from the English version, but demonstrably the same story in origin nevertheless. When however we turn to the chief adventure of Beowulf at the Danish court, the fight with Grendel (and that with Grendel's dam), the Saxonian parallel usually pointed out strikes one as extraordinarily far-fetched. I refer to Biarco's fight with the bear, an episode which Saxo disposes of in the following words:Talibus operum meritis exsultanti novam de se silvestris fera victoriam prsebuit. Ursum quippe eximiae magnitudinis obvium sibi inter dumeta factum iaculo confecit comitemque suum Hialtonem, quo viribus maior evaderet, applicato ore egestum beluse cruorem haurire iussit. Creditum namque erat hoc potionis genere corporei roboris incrementa præstari.
A Tudor Defense of Richard III
Authors: Zeeveld W. Gordon 
Published: November 2006

In 1684 William Winstanley summarized the Tudor reputation of Richard III:But as Honour is always attended on by Envy, so hath this worthy Princes fame been blasted by malicious traducers, who like Shakespear in his Play of him, render him dreadfully black in his actions, a monster of nature, rather then a man of admirable parts; whose slanders having been examined by wise and moderate men, they have onely found malice and ignorance to have been his greatest accusers, persons who can onely lay suspition to his charge; and suspition in Law is no more guilt than imagination.
The “Other Landscape” of Alain-Fournier
Authors: March Harold M. 
Published: November 2006

William James, in his Varieties of Religious Experience, makes the following statement:Lyric poetry and music are alive and significant only in proportion as they fetch these vague vistas of a life continuous with our own, beckoning and inviting, yet ever eluding our pursuit. We are alive or dead to the eternal inner message of the arts according as we have kept or lost this mystical susceptibility.
Psychometric properties of the Buss–Perry Aggression Questionnaire‐short form among law enforcement officers
Authors: Christopher Michael , Ferry Marissa , Simmons Akeesha , Vasquez Alicia , Reynolds Brooke , Grupe Daniel 
Published: March 2024

AbstractRepeatedly capturing national headlines, excessive law enforcement officer (LEO) use of force in critical incident encounters is one of the most divisive human rights issues in the United States. Valid and reliable measures of potential precursors to LEO excessive use of force, such as aggression, are needed. The Buss–Perry Aggression Questionnaire‐short form (BPAQ‐SF) is a validated measure of aggression across various populations; however, evaluation of this easily administered measure in high‐stress, frontline populations such as LEOs is limited. The primary goal of this study was to evaluate the validity, reliability, and sensitivity to change the BPAQ‐SF in a sample of LEOs. A confirmatory factor analysis suggested that the hierarchical solution provides a mixed fit to the data: SBχ²(25.84) = 62.50, p = .0001; comparative fit index = .94, non‐normed fit index = .92, root mean square error of approximation = .19 (90% confidence interval = .17–.21), standardized root mean squared residual = .08. The BPAQ‐SF demonstrated good internal consistency (α = .84) and test–retest reliability (r = .86), correlations in the expected direction with predictors of and buffers against aggression, and sensitivity to change among LEOs who participated in an intervention targeting aggression. Results support and extend previous findings suggesting that the BPAQ‐SF is a valid and reliable measure of aggression among LEOs.
Coccidioides Serologic Screening Practices in Individuals With Rheumatic and Autoimmune Diseases
Authors: Wilson Debbie L. , Kollampare Shubha , Kwoh C. Kent , Zhou Lili , Ashbeck Erin L. , Sudano Dominick , Lupi Maria , Miller Andrew , Smith Kristy , Lo‐Ciganic Wei‐Hsuan 
Published: March 2024

ObjectiveWe aimed to estimate Coccidioides serologic screening rates before initiation of biologic disease‐modifying antirheumatic drugs including tofacitinib (b/tsDMARDs), conventional synthetic disease‐modifying antirheumatic drugs (csDMARDs), and/or noninhaled corticosteroids.MethodsThis retrospective cohort study used 2011 to 2016 US Medicare claims data and included beneficiaries with rheumatic or autoimmune disease residing in regions within Arizona, California, and Texas endemic for Coccidioides spp. with ≥1 prescription for a b/tsDMARD, csDMARD, and/or noninhaled corticosteroid. We estimated prior‐year serologic screening incidence before initiating b/tsDMARDs, csDMARD, and/or noninhaled corticosteroid.ResultsDuring 2012 to 2016, 4,331 beneficiaries filled 64,049 prescriptions for b/tsDMARDs, csDMARDs, and noninhaled corticosteroids. Arizona's estimated screening rate was 20.1% (95% confidence interval [95% CI] 14.5–25.7) in the year before prescription initiation for b/tsDMARDs, 8.1% (95% CI 6.5–9.7) before csDMARDs, and 6.9% (95% CI: 5.6–8.2) before corticosteroids. Screening rates for b/tsDMARDs (2.8%, 95% CI 0.0–6.7), csDMARDs (1.0%, 95% CI 0.0–2.0), and corticosteroids (0.8%, 95% CI: 0.4–1.1) were negligible in California and undetected in Texas. Adjusted screening rate before prescription for b/tsDMARDs in Arizona increased from 14.5% (95% CI 7.5–21.5) in 2012 to 26.7% (95% CI 17.6–35.8) in 2016. Rheumatologists prescribing b/tsDMARDs in Arizona screened more than other providers (20.9% [95% CI 13.9–27.9] vs 12.9% [95% CI 5.9–20.0]).ConclusionCoccidioides serologic screening rates among Medicare beneficiaries with rheumatic/autoimmune diseases on b/tsDMARDs, csDMARDs, and noninhaled corticosteroids was low in Coccidioides spp.–US endemic regions between 2012 and 2016. Alignment of screening recommendations and clinical practice is needed.
3D Bioprinting Highly Elastic PEG‐PCL‐DA Hydrogel for Soft Tissue Fabrication and Biomechanical Stimulation
Authors: Lee Wenhan , Xu Cancan , Fu Huikang , Ploch Michael , D'Souza Sean , Lustig Steve , Long Xiaochun , Hong Yi , Dai Guohao 
Published: March 2024

Abstract3D bioprinting is a promising technology to fabricate custom geometries for tissue engineering. However, most bioprintable hydrogels are weak and fragile, difficult to handle, and cannot mimic the mechanical behaviors of the native soft elastic tissues. A visible light crosslinked, single‐network, elastic, and biocompatible hydrogel system based on an acrylate triblock copolymer of poly(ethylene glycol) PEG and polycaprolactone (PCL) (PEG‐PCL‐DA) is developed. To enable its application in the bioprinting of soft tissues, the hydrogel system is modified on its printability and biodegradability. Furthermore, it is hypothesized that this elastic material can better transmit pulsatile forces to cells, leading to enhanced cellular response under mechanical stimulation. This central hypothesis is tested using vascular conduits with smooth muscle cells (SMCs) cultured under pulsatile forces in a custom‐made bioreactor. The results show that vascular conduits made of PEG‐PCL‐DA hydrogel faithfully recapitulate the rapid stretch and recoil under the pulsatile pressure from 1 to 3 Hz frequency, which induces a contractile SMC phenotype, consistently upregulating the core contractile transcription factors. In summary, this work demonstrates the potential of elastic hydrogel for 3D bioprinting of soft tissues by fine‐tuning the printability, and biodegradability, while possessing robust elastic properties suitable for manual handling and biomechanical stimulation.
3D Bioprinted Human Skin Model Recapitulating Native‐Like Tissue Maturation and Immunocompetence as an Advanced Platform for Skin Sensitization Assessment
Authors: Bhar Bibrita , Das Eshani , Manikumar Kodieswaran , Mandal Biman B. 
Published: March 2024

AbstractPhysiologically‐relevant in vitro skin models hold the utmost importance for efficacy assessments of pharmaceutical and cosmeceutical formulations, offering valuable alternatives to animal testing. Here, an advanced immunocompetent 3D bioprinted human skin model is presented to assess skin sensitization. Initially, a photopolymerizable bioink is formulated using silk fibroin methacrylate, gelatin methacrylate, and photoactivated human platelet releasate. The developed bioink shows desirable physicochemical and rheological attributes for microextrusion bioprinting. The tunable physical and mechanical properties of bioink are modulated through variable photocuring time for optimization. Thereafter, the bioink is utilized to 3D bioprint “sandwich type” skin construct where an artificial basement membrane supports a biomimetic epidermal layer on one side and a printed pre‐vascularized dermal layer on the other side within a transwell system. The printed construct is further cultured in the air–liquid interface for maturation. Immunofluorescence staining demonstrated a differentiated keratinocyte layer and dermal extracellular matrix (ECM)‐remodeling by fibroblasts and endothelial cells. The biochemical estimations and gene‐expression analysis validate the maturation of the printed model. The incorporation of macrophages further enhances the physiological relevance of the model. This model effectively classifies skin irritative and non‐irritative substances, thus establishing itself as a suitable pre‐clinical screening platform for sensitization tests.
Engineering Quantum Light Sources with Flat Optics
Authors: Ma Jinyong , Zhang Jihua , Horder Jake , Sukhorukov Andrey A. , Toth Milos , Neshev Dragomir N. , Aharonovich Igor 
Published: March 2024

AbstractQuantum light sources are essential building blocks for many quantum technologies, enabling secure communication, powerful computing, and precise sensing and imaging. Recent advancements have witnessed a significant shift toward the utilization of “flat” optics with thickness at subwavelength scales for the development of quantum light sources. This approach offers notable advantages over conventional bulky counterparts, including compactness, scalability, and improved efficiency, along with added functionalities. This review focuses on the recent advances in leveraging flat optics to generate quantum light sources. Specifically, the generation of entangled photon pairs through spontaneous parametric down‐conversion in nonlinear metasurfaces, and single photon emission from quantum emitters including quantum dots and color centers in 3D and 2D materials are explored. The review covers theoretical principles, fabrication techniques, and properties of these sources, with particular emphasis on the enhanced generation and engineering of quantum light sources using optical resonances supported by nanostructures. The diverse application range of these sources is discussed and the current challenges and perspectives in the field are highlighted.
Facile Fabrication of FePO4–V2O5–Graphene Oxide Recovered From Spent LiFePO4 Batteries as High‐Performance Cathode for Lithium/Sodium‐Ion Batteries
Authors: Xiao Fuyu , Lai Wenbin , Zeng Shihan , He Lingjun , Ge Mingyang , Luo Fenqiang , Xiong Peixun , Lin Hui , Lin Chuyuan , Luo Yongjin , Zhang Jixiang , Qian Qingrong , Chen Qinghua , Zeng Lingxing 
Published: March 2024

AbstractThe resource scarcity and pollution leakage risk caused by discarding the spent power lithium‐ion batteries has aroused growing concern. Recovering and regenerating the cathode material from spent power lithium‐ion batteries in an easy and environmentally friendly manner remains a significant challenge and an area of focus in battery research. Hence, a green and convenient method to recover FePO4 from spent LiFePO4 cathode powder by using Na2S2O8 as an oxidizer and as cathode materials for lithium/sodium‐ion batteries (LIBs/SIBs) is reported. Benefiting from the remarkable graphene oxide (GO) and vanadium oxide (V2O5) coating, the regenerated FePO4–V2O5–graphene oxide (FePO4–V2O5–GO) is suitable for Li/Na storage (153 mAh g−1 at 0.2C/118 mAh g−1 at 0.5C). The high capacity retention, that stable for 300 cycles in LIBs and 300 cycles for SIBs, is also realized due to the stable structure. This work provides a green strategy for regenerating the cathode of spent lithium‐ion batteries and designing cathodes of alkali metal ion batteries.
Magnetic Supramolecular Spherical Arrays: Direct Formation of Micellar Cubic Mesophase by Lanthanide Metallomesogens with 7‐Coordination Geometry
Authors: Komiyama Nao , Ohkubo Takahiro , Maeda Yoshiki , Saeki Yuya , Ichikuni Nobuyuki , Masu Hyuma , Kanoh Hirofumi , Ohara Koji , Takahashi Ryunosuke , Wadati Hiroki , Takagi Hideaki , Miwa Yohei , Kutsumizu Shoichi , Kishikawa Keiki , Kohri Michinari 
Published: March 2024

AbstractHere, an unprecedented phenomenon in which 7‐coordinate lanthanide metallomesogens, which align via hydrogen bonds mediated by coordinated H2O molecules, form micellar cubic mesophases at room temperature, creating body‐centered cubic (BCC)‐type supramolecular spherical arrays, is reported. The results of experiments and molecular dynamics simulations reveal that spherical assemblies of three complexes surrounded by an amorphous alkyl domain spontaneously align in an energetically stable orientation to form the BCC structure. This phenomenon differs greatly from the conventional self‐assembling behavior of 6‐coordinated metallomesogens, which form columnar assemblies due to strong intermolecular interactions. Since the magnetic and luminescent properties of different lanthanides vary, adding arbitrary functions to spherical arrays is possible by selecting suitable lanthanides to be used. The method developed in this study using 7‐coordinate lanthanide metallomesogens as building blocks is expected to lead to the rational development of micellar cubic mesophases.
Nanoparticles Synergize Ferroptosis and Cuproptosis to Potentiate Cancer Immunotherapy
Authors: Li Youyou , Liu Jing , Chen Yimei , Weichselbaum Ralph R. , Lin Wenbin 
Published: March 2024

AbstractThe recent discovery of copper‐mediated and mitochondrion‐dependent cuproptosis has aroused strong interest in harnessing this novel mechanism of cell death for cancer therapy. Here the design of a core‐shell nanoparticle, CuP/Er, for the co‐delivery of copper (Cu) and erastin (Er) to cancer cells for synergistic cuproptosis and ferroptosis is reported. The anti‐Warburg effect of Er sensitizes tumor cells to Cu‐mediated cuproptosis, leading to irreparable mitochondrial damage by depleting glutathione and enhancing lipid peroxidation. CuP/Er induces strong immunogenic cell death, enhances antigen presentation, and upregulates programmed death‐ligand 1 expression. Consequently, CuP/Er promotes proliferation and infiltration of T cells, and when combined with immune checkpoint blockade, effectively reinvigorates T cells to mediate the regression of murine colon adenocarcinoma and triple‐negative breast cancer and prevent tumor metastasis. This study suggests a unique opportunity to synergize cuproptosis and ferroptosis with combination therapy nanoparticles to elicit strong antitumor effects and potentiate current cancer immunotherapies.
The impact of access to agricultural advisory services on input use and farm performance: Evidence from Senegal
Authors: Ricome Aymeric , Faye Amy , Fall Cheickh S. , Gomez‐y‐Paloma Sergio 
Published: March 2024

AbstractPerformant agricultural advisory services (AAS) in Africa are crucial for improving the agricultural productivity and food security of the farm households. Yet, evidence‐based study on the impacts of AAS on farm performance are scarce, especially in West African countries. This study evaluates the impact of access to AAS on input use and farm performance in Senegal, employing the instrumental variable and control function approaches accounting for selection bias. The approaches are also employed to several sub‐samples to see if the impacts are heterogeneous across crop types and fertilizer use, and matching techniques are applied to test the robustness of the results. Results show that the highest positive impact of AAS is on yield, while the impacts on gross margin and improved seeds uptake are very modest. Access to AAS has no effect on fertilizer uptake. It also finds that AAS impacts positively cereal production and farmers using no fertilizer but has no effect on the legume and horticultural crop production and on farmers using fertilizer. Given the Senegalese government and donors have put a lot of effort into developing an efficient AAS system, a consideration of the identified weaknesses is required to improve its efficiency. [EconLit Citations: Q12, Q16]
Adaptively exploring the feature space of flowsheets
Authors: Höller Johannes , Bubel Martin , Heese Raoul , Ludl Patrick Otto , Schwartz Patrick , Schwientek Jan , Asprion Norbert , Wlotzka Martin , Bortz Michael 
Published: March 2024

AbstractSimulation and optimization of chemical flowsheets rely on the solution of a large number of nonlinear equations. Finding such solutions can be supported by constructing machine learning‐based surrogate models, relating features and outputs by simple, explicit functions. In order to generate training data for those surrogate models computationally efficiently, schemes to adaptively sample the feature space are mandatory. In this article, we present a novel family of utility functions to favor an adaptive, Bayesian exploration of the feature space in order to identify regions that are convergent and fulfill customized inequality constraints. Moreover, points close to the Pareto‐optimal domain with respect to conflicting objectives can be identified, serving as good start values for a multicriteria optimization of the flowsheet. The benefit is illustrated by small toy‐examples as well as by industrially relevant chemical flowsheets.