bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of the antifungal activity of the pyrimidine analogs flucytosine and carmofur against human-pathogenic dematiaceous fungi
Authors: Coelho Rowena Alves , Almeida-Silva Fernando , Figueiredo-Carvalho Maria Helena Galdino , Rabello Vanessa Brito de Souza , de Souza Gabriela Rodrigues , Lourenço Maria Cristina da Silva , Rodrigues Marcio L , Almeida-Paes Rodrigo 
Published: March 2024

Abstract
Chromoblastomycosis (CBM) and pheohyphomycosis (PHM) are the most common implantation mycoses caused by dematiaceous fungi. In the past, flucytosine (5-FC) has been used to treat CBM, but development of resistance is common. Carmofur belongs to the same class as 5-FC and has in vitro inhibitory activity against the main agents of CBM and PHM. The aim of this study was to compare the action of these two pyrimidine analog drugs against CBM and PHM agents. The minimum inhibitory concentration (MIC) and the selectivity index based on cytotoxicity tests of these two drugs against some agents of these mycoses were determined, with carmofur presenting a higher selectivity index than 5-FC. Carmofur demonstrated here synergistic interactions with itraconazole and amphotericin B against Exophiala heteromorpha, Fonsecaea pedrosoi, Fonsecaea monophora, and Fonsecaea nubica strains. Additionally, carmofur plus itraconazole demonstrated here synergism against a Phialophora verrucosa strain. To evaluate the development of carmofur resistance, passages in culture medium containing subinhibitory concentrations of this pyrimidine analog were carried out, followed by in vitro susceptibility tests. Exophiala dermatitidis quickly developed resistance, whereas F. pedrosoi took seven passages in carmofur-supplemented medium to develop resistance. Moreover, resistance was permanent in E. dermatitidis but transient in F. pedrosoi. Hence, carmofur has exhibited certain advantages, albeit accompanied by limitations such as the development of resistance, which was expected as with 5-FC. This underscores its therapeutic potential in combination with other drugs, emphasizing the need for a meticulous evaluation of its application in the fight against dematiaceous fungi.
Analysing radio pulsar timing noise with a Kalman filter: a demonstration involving PSR J1359−6038
Authors: O’Neill Nicholas J , Meyers Patrick M , Melatos Andrew 
Published: March 2024

ABSTRACT
In the standard two-component crust-superfluid model of a neutron star, timing noise can arise when the two components are perturbed by stochastic torques. Here it is demonstrated how to analyse fluctuations in radio pulse times of arrival with a Kalman filter to measure physical properties of the two-component model, including the crust-superfluid coupling time-scale and the variances of the crust and superfluid torques. The analysis technique, validated previously on synthetic data, is applied to observations with the Molonglo Observatory Synthesis Telescope of the representative pulsar PSR J1359−6038. It is shown that the two-component model is preferred to a one-component model, with log Bayes factor 6.81 ± 0.02. The coupling time-scale and the torque variances on the crust and superfluid are measured with 90 per cent confidence to be $10^{7.1^{+0.8}_{-0.5}}$$\rm {s}$ and $10^{-24.0^{+0.4}_{-5.6}}$$\rm {rad^2~s^{-3}}$ and $10^{-21.7^{+3.5}_{-0.9}}$$\rm {rad^2~s^{-3}}$, respectively.
A targeted radio pulsar survey of redback candidates with MeerKAT
Authors: Thongmeearkom T , Clark C J , Breton R P , Burgay M , Nieder L , Freire P C C , Barr E D , Stappers B W , Ransom S M , Buchner S , Calore F , Champion D J , Cognard I , Grießmeier J -M , Kramer M , Levin L , Padmanabh P V , Possenti A , Ridolfi A , Krishnan V Venkatraman , Vleeschower L 
Published: March 2024

ABSTRACT
Redbacks are millisecond pulsar binaries with low-mass, irradiated companions. These systems have a rich phenomenology that can be used to probe binary evolution models, pulsar wind physics, and the neutron star mass distribution. A number of high-confidence redback candidates have been identified through searches for variable optical and X-ray sources within the localization regions of unidentified but pulsar-like Fermi-LAT gamma-ray sources. However, these candidates remain unconfirmed until pulsations are detected. As part of the TRAPUM project, we searched for radio pulsations from six of these redback candidates with MeerKAT. We discovered three new radio millisecond pulsars, PSRs J0838−2827, J0955−3947, and J2333−5526, confirming their redback nature. PSR J0838−2827 remained undetected for 2 yr after our discovery despite repeated observations, likely due to evaporated material absorbing the radio emission for long periods of time. While, to our knowledge, this system has not undergone a transition to an accreting state, the disappearance, likely caused by extreme eclipses, illustrates the transient nature of spider pulsars and the heavy selection bias in uncovering their radio population. Radio timing enabled the detection of gamma-ray pulsations from all three pulsars, from which we obtained 15-yr timing solutions. All of these sources exhibit complex orbital period variations consistent with gravitational quadrupole moment variations in the companion stars. These timing solutions also constrain the binary mass ratios, allowing us to narrow down the pulsar masses. We find that PSR J2333−5526 may have a neutron star mass in excess of 2 M⊙.
Magnetically arrested discs in FR I radio galaxies
Authors: He Han , You Bei , Jiang Ning , Cao Xinwu , Hu Jingfu , Sheng Zhenfeng , Yao Su , Czerny Bozena 
Published: March 2024

ABSTRACT
A sample of 17 Fanaroff–Riley type I (FR I) radio galaxies constructed from the 3CR catalogue, which is characterized by edge-darkened radio structures, is studied. The optical core luminosities derived from Hubble Space Telescope observation are used to estimate the Eddington ratios which are found to be below 10−3.4 for this sample. This is supported by the Baldwin–Phillips–Terlevich optical diagnostic diagrams derived with the spectroscopic observation of Telescopio Nazionale Galileo, suggesting that these sources are of low-ionization nuclear emission-line regions. It implies that the accretion in these FR I sources can be modelled as advection-dominated accretion flows (ADAFs). Given the low accretion rate, the predicted jet power with a fast-spinning black hole (BH) a = 0.95 in the Blandford–Znajek mechanics is lower than the estimated one for almost all the sources in our sample. Such powerful jets indicate the presence of magnetically arrested discs (MAD) in the inner region of the ADAF, in the sense that the magnetic fields in the inner accretion zone are strong. Moreover, we show that, even in the MAD scenario, the BH spins in the sample are most likely moderate and/or fast with a ≳ 0.5.
Baryon acoustic scale at zeff = 0.166 with the SDSS blue galaxies
Authors: Avila Felipe , de Carvalho Edilson , Bernui Armando , Lima Hanna , Nunes Rafael C 
Published: March 2024

ABSTRACT
The baryon acoustic oscillations (BAOs) phenomenon provides a unique opportunity to establish a standard ruler at any epoch in the history of the evolving universe. The key lies in identifying a suitable cosmological tracer to conduct the measurement. In this study, we focus on quantifying the sound horizon scale of BAO in the Local Universe. Our chosen cosmological tracer is a sample of blue galaxies from the Sloan Digital Sky Survey (SDSS), positioned at the effective redshift $z_{{\rm eff}} = 0.166$. Utilizing Planck-CMB input values for redshift-to-distance conversion, we derive the BAO scale $s_{{\rm BAO}} = 100.28 ^{+10.79} _{-22.96}$ Mpc h−1 at the 1$\sigma$ confidence level. Subsequently, we extrapolate the BAO signal scale in redshift space: $\Delta z_{{\rm BAO}}(z_{\rm eff}=0.166)=0.0361^{+0.00262}_ {-0.0055}$. This measurement holds the potential to discriminate among dark energy models within the Local Universe. To validate the robustness of our methodology for BAO scale measurement, we conduct three additional BAO analyses using different cosmographic approaches for distance calculation from redshifts. These tests aim to identify possible biases or systematics in our measurements of $s_{{\rm BAO}}$. Encouragingly, our diverse cosmographic approaches yield results in statistical agreement with the primary measurement, indicating no significant deviations. Conclusively, our study contributes with a novel determination of the BAO scale in the Local Universe, at $z_{{\rm eff}} = 0.166$, achieved through the analysis of the SDSS blue galaxies cosmic tracer.
Constraints on the ultra-high energy cosmic ray output of gamma-ray bursts
Authors: Moore E , Gendre B , Orange N B , Panther F H 
Published: March 2024

ABSTRACT
Ultra-high energy cosmic rays are the most extreme energetic particles detected on Earth, however, their acceleration sites are still mysterious. We explore the contribution of low-luminosity gamma-ray bursts to the ultra-high energy cosmic ray flux, since they form the bulk of the nearby population. We analyse a representative sample of these bursts detected by BeppoSAX, INTEGRAL, and Swift between 1998–2016, and found that in order to reconcile our theoretical flux with the observed flux, these bursts should accelerate at most 10−13 M⊙ of ultra-high energy cosmic rays.
A Bayesian approach to strong lens finding in the era of wide-area surveys
Authors: Holloway Philip , Marshall Philip J , Verma Aprajita , More Anupreeta , Cañameras Raoul , Jaelani Anton T , Ishida Yuichiro , Wong Kenneth C 
Published: March 2024

ABSTRACT
The arrival of the Vera C. Rubin Observatory’s Legacy Survey of Space and Time (LSST), Euclid-Wide and Roman wide-area sensitive surveys will herald a new era in strong lens science in which the number of strong lenses known is expected to rise from $\mathcal {O}(10^3)$ to $\mathcal {O}(10^5)$. However, current lens-finding methods still require time-consuming follow-up visual inspection by strong lens experts to remove false positives which is only set to increase with these surveys. In this work, we demonstrate a range of methods to produce calibrated probabilities to help determine the veracity of any given lens candidate. To do this we use the classifications from citizen science and multiple neural networks for galaxies selected from the Hyper Suprime-Cam survey. Our methodology is not restricted to particular classifier types and could be applied to any strong lens classifier which produces quantitative scores. Using these calibrated probabilities, we generate an ensemble classifier, combining citizen science, and neural network lens finders. We find such an ensemble can provide improved classification over the individual classifiers. We find a false-positive rate of 10−3 can be achieved with a completeness of 46 per cent, compared to 34 per cent for the best individual classifier. Given the large number of galaxy–galaxy strong lenses anticipated in LSST, such improvement would still produce significant numbers of false positives, in which case using calibrated probabilities will be essential for population analysis of large populations of lenses and to help prioritize candidates for follow-up.
An octopamine-specific GRAB sensor reveals a monoamine relay circuitry that boosts aversive learning
Authors: Lv Mingyue , Cai Ruyi , Zhang Renzimo , Xia Xiju , Li Xuelin , Wang Yipan , Wang Huan , Zeng Jianzhi , Xue Yifei , Mao Lanqun , Li Yulong 
Published: March 2024

ABSTRACT
Octopamine (OA), analogous to norepinephrine in vertebrates, is an essential monoamine neurotransmitter in invertebrates that plays a significant role in various biological functions, including olfactory associative learning. However, the spatial and temporal dynamics of OA in vivo remain poorly understood due to limitations associated with the currently available methods used to detect it. To overcome these limitations, we developed a genetically encoded GPCR activation-based (GRAB) OA sensor called GRABOA1.0. This sensor is highly selective for OA and exhibits a robust and rapid increase in fluorescence in response to extracellular OA. Using GRABOA1.0, we monitored OA release in the Drosophila mushroom body (MB), the fly's learning center, and found that OA is released in response to both odor and shock stimuli in an aversive learning model. This OA release requires acetylcholine (ACh) released from Kenyon cells, signaling via nicotinic ACh receptors. Finally, we discovered that OA amplifies aversive learning behavior by augmenting dopamine-mediated punishment signals via Octβ1R in dopaminergic neurons, leading to alterations in synaptic plasticity within the MB. Thus, our new GRABOA1.0 sensor can be used to monitor OA release in real time under physiological conditions, providing valuable insights into the cellular and circuit mechanisms that underlie OA signaling.
Invasive Candida Infection in Patients With Bacterial Infective Endocarditis
Authors: Combs Travis , Stoner Bobbi Jo , McCoy Parker , Reda Hassan , Sekela Michael , El-Dalati Sami 
Published: March 2024

Abstract
Over 21 months, 12 patients with invasive Candida infections detected during the course of treatment of bacterial endocarditis, including 11 with candidemia, were identified. Invasive Candida infections can occur as a complication of bacterial endocarditis and may occur more frequently in patients with injection drug use and broad-spectrum antibiotic exposure.
AGC kinases OXI1 and AGC2-2 regulate camalexin secretion and disease resistance by phosphorylating transporter PDR6
Authors: Han Juan , Liu Chang-xin , Liu Jian , Wang Cheng-run , Wang Shun-chang , Miao Guopeng 
Published: March 2024

Abstract
Plant transporters regulating the distribution of secondary metabolites play critical roles in defending against pathogens, insects, and interacting with beneficial microbes. The phosphorylation of these transporters can alter their activity, stability, and intracellular protein trafficking. However, the regulatory mechanism underlying this modification remains elusive. In this study, we discovered two orthologs of mammalian PKA, PKG, and PKC (AGC) kinases, oxidative signal-inducible 1 (OXI1) and its closest homologue, AGC subclass 2 member 2 (AGC2-2; 75% amino acid sequence identity with OXI1), associated with the extracellular secretion of camalexin and Arabidopsis (Arabidopsis thaliana) resistance to Pseudomonas syringae, and Botrytis cinerea. These kinases can undergo in vitro kinase reactions with three pleiotropic drug resistance (PDR) transporters: PDR6, PDR8, and PDR12. Moreover, our investigation confirmed PDR6 interaction with OXI1 and AGC2-2. By performing LC–MS/MS and parallel reaction monitoring, we identified the phosphorylation sites on PDR6 targeted by these kinases. Notably, chitin-induced PDR6 phosphorylation at specific residues, namely S31, S33, S827, and T832. Additional insights emerged by expressing dephosphorylated PDR6 variants in a pdr6 mutant background, revealing that the target residues S31, S33, and S827 promote PDR6 efflux activity, while T832 potentially contributes to PDR6 stability within the plasma membrane. The findings of this study elucidate partial mechanisms involved in the activity regulation of PDR-type transporters, providing valuable insights for their potential application in future plant breeding endeavors.
Why and how is the power of Big Tech increasing in the policy process? The case of generative AI
Authors: Khanal Shaleen , Zhang Hongzhou , Taeihagh Araz 
Published: March 2024

Abstract
The growing digitalization of our society has led to a meteoric rise of large technology companies (Big Tech), which have amassed tremendous wealth and influence through their ownership of digital infrastructure and platforms. The recent launch of ChatGPT and the rapid popularization of generative artificial intelligence (GenAI) act as a focusing event to further accelerate the concentration of power in the hands of the Big Tech. By using Kingdon’s multiple streams framework, this article investigates how Big Tech utilize their technological monopoly and political influence to reshape the policy landscape and establish themselves as key actors in the policy process. It explores the implications of the rise of Big Tech for policy theory in two ways. First, it develops the Big Tech-centric technology stream, highlighting the differing motivations and activities from the traditional innovation-centric technology stream. Second, it underscores the universality of Big Tech exerting ubiquitous influence within and across streams, to primarily serve their self-interests rather than promote innovation. Our findings emphasize the need for a more critical exploration of policy role of Big Tech to ensure balanced and effective policy outcomes in the age of AI.
Activation policy: bruised and battered but still standing
Authors: Andersen Niklas A , Larsen Flemming 
Published: March 2024

Abstract
Policies aimed at upskilling, motivating and/or disciplining the unemployed have remained a cornerstone of most OECD countries’ employment policies since the 1990s. Central to these policies is the idea of activation – i.e. the premise that benefit entitlement is conditional on one’s participation in some kind of activity. This article seek to understand how this idea of activation has proven so enduring by analyzing the international development of Activation Policies since 1990 through the lens offered by the concept of ideational robustness. It is analyzed how the robustness of the idea of activation has been continuously challenged through critiques raised against the effects, the legitimacy and the relevance of activation policies. Yet, in each of these moments of contest, proponents of the idea of activation succeeded in keeping the idea relevant as a point of reference for policymaking. They did so by rebalancing disciplinary and enabling approaches to activation, adding a new scope of application for activation policies, and rearticulating the underlying assumption about client agency. The analysis further reveals how these robustness mechanisms succeeded in appropriating the critiques due to their inscription within the technical and seemingly de-political language concerning effect evaluations, implementation deficits, and new forms of governance. Policymakers were thereby able to downplay normative questions of the legitimacy, fairness, and justice of activation policies. The idea of activation has thus taken on a status as an objective to be implemented as effective and efficiently as possible rather than as an idea to be discussed or challenged. However, while the idea of activation remains robust, the same cannot be said of the governance and implementation structures of activation policies. Our study suggest that the near-constant reforms of these governance arrangements and implementation structures during the last 30 years are partly a consequence of critique being skewed from the idea of activation to these structures and arrangements. The robustness of the idea of activation has thus, rather paradoxically, come about by reducing the robustness of specific activation policies and governance arrangements.
On the mechanism for winter stem pressure build-up in walnut trees
Authors: Bozonnet Cyril , Saudreau Marc , Badel Eric , Charrier Guillaume , Améglio Thierry 
Published: March 2024

Abstract
Xylem embolism is a significant factor in tree mortality. Restoration of hydraulic conductivity after massive embolization of the vascular system requires the application of positive pressure to the vessels and/or the creation of new conductive elements. Some species generate positive pressure from the root system to propagate pressure in distal, aboveground organs in spring, whereas other species generate positive pressure locally at the stem level during winter. We provide a mechanistic explanation for winter stem pressure build-up in the walnut tree. We have developed a physical model that accounts for temperature fluctuations and phase transitions. This model is based on the exchange of water and sugars between living cells and vessels. Our computations demonstrate that vessel pressurization can be attributed to the transfer of water between vessels across the parenchyma rays, which is facilitated by a radial imbalance in sugar concentration. The ability to dispose of soluble sugars in living cells, and to transport them between living cells and up to the vessels, is identified as the main drivers of stem pressure build-up in the walnut tree.
Better Roads, Better Off? Evidence on Upgrading Roads in Tanzania
Authors: Dumas Christelle , Játiva Ximena 
Published: March 2024

ABSTRACT
Spatial isolation is considered to be one of the main determinants of poverty. Therefore, many transport investments are undertaken with the stated objective of poverty reduction. This paper evaluates the effect of a Tanzanian program that rehabilitated 2,500 km of major roads on rural livelihoods. The analysis uses a large set of variables describing household behavior in order to provide a complete picture of the adjustments. The identification consists of combining a household fixed effects strategy with propensity score matching. Some damaging effects of the program are found on the rural population in the two years following the intervention: the price of rice decreases; households reallocate labor away from agriculture and provide more wage work, but the increase in wage income does not compensate for the loss in agricultural income. Nor do households seem to be benefiting from the fall in the price of rice at consumption level. These results are consistent with rural households facing increased competition due to reduced transportation costs.
Phylogeography of Korean field mouse Apodemus peninsulae (Rodentia: Muridae): an update
Authors: Chelomina Galina N , Meschersky Ilya G , Gajduchenko Helen , Borisov Yuri M 
Published: March 2024

Abstract
To better understand the evolutionary and demographic histories of the Korean field mouse Apodemus peninsulae we examined mitochondrial (mt) cytochrome b gene sequences of 200 specimens from 65 localities in China, Japan, Korea, Mongolia, and Russia. The phylogenetic and phylogeographic analyses revealed three major groups of haplotypes: “Chinese” (C), “Korean” (K) and “Russian” (R). C includes only the samples from southern and central China, K combines all samples from Korean Peninsula and some samples from Siberia, and R comprises all samples from Russian Far East, Japan, and most samples from Siberia. Both R and K also include the samples from Northern China and Mongolia. Coalescent-based approaches suggest a link between separation of these groups and intensive Kung-Huang Pleistocene uplift event of the Tibetan Plateau. The rapid expansion events in R are associated with marine isotope stages (MIS) 3 and 4, and in K with MIS 6; no sings of rapid expansion were found in C. The widespread settlement of the northeast occurred in two waves, close in time: 1) to Northern China and Korean Peninsula, and then 2) to most of Siberia, the Russian Far East and Japan; parts of Siberia, Mongolia and northern China were colonized twice.