bluuebunny/crossref_metadata_2025_split huggingface dataset:
Successes and Challenges in Implementing Stepped Care for Mental Health in Jordan: A Qualitative Process Evaluation
Authors: Dardas Latefa Ali , Habashneh Rand , Keyan Dharni , Ali Ammar , Saleh Rayan , Aqel Ibrahim Said , Abualhaija Adnan , Bryant Richard 
Published: February 2025

ABSTRACTThe stepped care model is a hierarchical healthcare approach that matches treatment intensity to a patient's condition, ensuring efficient resource use while providing appropriate care. This study conducted a qualitative process evaluation to assess the feasibility, acceptability, and contextual suitability of a multicenter, parallel‐group, superiority, randomized controlled trial addressing psychological distress among adults in Jordan. The trial applied the stepped care framework using two scalable WHO interventions adapted to the Jordanian context. Qualitative data was gathered through focus group discussions and phone interviews with 44 participants, facilitators, and assessors. Two themes emerged: (1) Navigating Transformations, highlighting participants' personal growth, including improved self‐esteem, family dynamics, and coping mechanisms, alongside the benefits of group sessions and supportive relationships with facilitators; and (2) Navigating Challenges and Improvements, focusing on logistical and personal difficulties such as scheduling issues, and suggestions for improving accessibility and engagement. Findings support the feasibility of the stepped care model as a promising approach to providing accessible and effective mental health support in Jordan. The study calls for hybrid models integrating group and individual support while emphasizing the need for enhanced facilitator training and support systems.
Relationships and Synergistic Effects of Body Mass Index and Blood Glucose Marker on the Ankle‐Brachial Index in Adult With Type 2 Diabetes Mellitus: A Cross‐Sectional Study
Authors: Fadlilah Siti , Nurrahma Herlin Ajeng , Sumarni Sumarni , Tsai Jia Ruey , Wang Wei‐Jun , Tsai Hsiu Ting 
Published: February 2025

ABSTRACTThis study aimed to identify the independent and synergistic effects of body mass index, fasting blood glucose, and hemoglobin A1c on ankle‐brachial index in type 2 diabetes mellitus. This cross‐sectional study involved 1096 participants who were measured using questionnaires, a digital scale, and a height measurement device. Blood marker was examined using fasting venous blood. The ankle‐brachial index was measured using Doppler ultrasound. A multinomial logistic regression was applied for adjusting confounders. Participants who were obese significantly increased 2.12‐ and 1.86‐fold risk of a low and a high ankle‐brachial index (p <  0.05), respectively. Participants with abnormal fasting blood glucose significantly increased 1.79‐ and 2.05‐fold risk of a low and a high ankle‐brachial index (p <  0.05). Participants with hemoglobin A1c > 6.5% significantly increased 1.71‐ and 1.76‐fold risk of a low and a high ankle‐brachial index (p <  0.05), respectively. Participants with abnormalities for all three indices synergistically increased 12.31‐ and 5.31‐fold risk of a low and a high ankle‐brachial index (p <  0.001), respectively. Abnormal body mass index, fasting blood glucose, and hemoglobin A1c readings significantly, independently, and synergistically increased the risk of an abnormal ankle‐brachial index.
Examining the Relationship Between Healthy Life Awareness and Psychological Well‐Being in Liver Transplantation Patients: A Structural Equation Model
Authors: Meşe Sevinç , Harmancı Pınar 
Published: February 2025

ABSTRACTThis study aimed to evaluate the mediating role of healthy life awareness in the relationship between the sociodemographic characteristics and psychological well‐being of liver transplant patients. The sample of the study consisted of 202 patients aged between 18 and 69 years who underwent liver transplantation surgery at a hospital in Turkey. The data were collected using a sociodemographic information form, the “Healthy Life Awareness Scale” and the “Psychological Well‐Being Scale.” Healthy life awareness directly predicted psychological well‐being (β: 0.68, p < 0.01). Education positively predicted psychological well‐being both directly (β: 0.14, p < 0.05) and indirectly through healthy life awareness (β: 0.76, p < 0.05). Age indirectly predicted healthy life awareness and psychological well‐being through employment status and education. The income level positively predicted healthy life awareness (β: 0.14, p < 0.05), whereas gender (male) negatively predicted healthy life awareness (β: −0.22, p < 0.01). Healthy life awareness was a significant predictor of psychological well‐being. The results of this study may offer valuable information for healthcare providers to tailor interventions that also support mental and emotional health, which is critical to the long‐term success of transplant outcomes.
Beyond species and spatial boundaries: Enabling long‐distance gene silencing in plants via guanidinium‐siRNA nanoparticles
Authors: Lin Shujin , Zhang Qian , Bai Shiyan , Yang Liwen , Qin Guannan , Wang Liyuan , Wang Wenbin , Cheng Cui , Zhang Da , Lu Chunhua , Yuan Jifeng , Li Jingying , Yang Huanghao , Gu Xiaofeng , Han Xiao 
Published: February 2025

SummaryRNA interference (RNAi) has been widely used in agriculture. However, it is well accepted that common methods of plant RNAi are species‐dependent and lack systematic efficiency. This study designed a thiolated siRNA nanoparticle, guanidinium (Gu+)‐containing disulfide assembled siRNA (Gu+‐siRNA), demonstrating remarkable species independence and efficient systemic gene silencing across different plant species. Our results indicate that this approach effectively utilizes the plant vascular system to deliver siRNA, enabling long‐distance gene silencing across both monocot and dicot plants, such as rice and Arabidopsis. By applying this method, we successfully targeted and silenced key genes like STM, WER, MYB23, GD1, EIL1, and EIL2, which regulate plant development and enhance salt tolerance. This delivery system significantly expands the application of RNAi technology across different plants, serving as a valuable tool for advancing agricultural biotechnology, enhancing crop resistance, and improving agricultural productivity, while aligning with global goals for sustainable food production and crop improvement.
Oral Tofacitinib for the Management of Moderate to Severe Alopecia Areata in Children and Adolescents: A Retrospective Study of 36 Patients
Authors: Mahajan Rahul , Mehta Hitaishi , De Dipankar , Handa Sanjeev 
Published: February 2025

ABSTRACTBackgroundOral tofacitinib shows promise for pediatric alopecia areata (AA), but more data on its efficacy and safety are needed.MethodsWe analyzed 36 patients aged ≤ 16 years with moderate to severe AA (SALT score > 20) who received at least 6 months of oral tofacitinib.ResultsSALT75 was achieved in 72.2% (26/36) and SALT100 in 52.8% (19/36) within 4.1 ± 1.7 and 6.7 ± 2.8 months, respectively; 27.8% (10/36) were non‐responders. Nine patients had adverse events, with two requiring treatment discontinuation.ConclusionTofacitinib is effective for pediatric AA, with rapid regrowth in responders. The durability of benefit and need for long term maintenance therapy require further investigation.
Post‐Liver Transplantation–Burkitt Lymphoma in Children: A Single‐Center Study of Clinical Characteristics, Treatment, and Outcomes
Authors: Chen Tianran , Zheng Weiping , Wang Ruofan , Dong Chong , Sun Chao , Wang Kai , Han Chao , Wei Xinzhe , Gao Wei 
Published: February 2025

ABSTRACTBackgroundPost‐liver transplantation–Burkitt lymphoma (PLT‐BL) is an aggressive and life‐threatening complication after pediatric liver transplantation. The research on the disease characteristics, treatment, and prognosis of pediatric PLT‐BL is limited.MethodsA retrospective, observational study was performed to analyze the disease characteristics, treatment, and outcomes in 12 pediatric liver transplant (LT) recipients diagnosed with PLT‐BL.ResultsThe medium time from liver transplantation to diagnosis was 32.71 months (range, 25.78–37.85 months). All patients (100%) tested positive for EBV viremia at diagnosis. Abdomen and peripheral lymph nodes were the most frequently involved sites (11 [91.66%] and 10 [83.33%], respectively). Three pediatric patients were diagnosed as relapsed or refractory PLT‐BL and treated with chimeric antigen receptor (CAR) T‐cell therapy, and two of them achieved complete remission (CR). Nine patients were alive with CR at the last follow‐up. Three deaths were attributed to progression and tumor lysis syndrome, characterized by significantly elevated lactate dehydrogenase (LDH) levels (p = 0.027), more advanced tumor stages (p = 0.045), and an increased number of involved sites (p = 0.009). With a median follow‐up of 2.7 years after diagnosis, the event‐free survival (EFS) and overall survival (OS) rates for PLT‐BL patients were 66.7% and 74.1%, respectively. In four patients, immunosuppression was successfully withdrawn and they maintained tolerance status.ConclusionElevated LDH levels, more advanced tumor stages, and increased number of involved sites are potentially associated with poor outcome. Immunosuppression withdrawal is a safe and feasible approach for PLT‐BL.
Do engagement best practices motivate preparedness intentions? Data from earthquake workshops for Spanish speakers
Authors: MacPherson‐Krutsky Carson , Brand Brittany D. , Lindell Michael K. 
Published: February 2025

AbstractCommunities exposed to Cascadia Subduction Zone earthquakes have diverse information needs. However, information about earthquake risk is often developed for general audiences and is rarely tested for its effectiveness at improving risk understanding or preparedness intentions for those general audiences, let alone ethnic minorities. Best practices in risk communication suggest that providing information that is personalized, clear, and culturally appropriate will improve people's willingness to engage with the material and improve learning outcomes. This study reports the test of a 2‐h earthquake preparedness workshop that was based on active learning principles, addressed earthquake impacts, preparedness actions, and included goal setting activities to motivate participants’ preparedness. We engaged local facilitators to deliver a culturally appropriate workshop in Spanish to 52 participants online and in‐person. A pretest/posttest evaluation revealed significant increases in expected earthquake consequences, risk area accuracy for shaking zone and liquefaction zone, positive affect, self‐efficacy, and, most important, preparedness intentions. These results indicate that an active learning strategy is an effective method of risk communication. However, further research is needed to identify ways to change the variables that had weak or nonsignificant impacts and to determine if the preparedness intentions ultimately produce preparedness actions.
Integrable Hierarchy for Homogeneous Realization of the Toroidal Lie Algebra Lr+1tor(slℓ)$\mathcal {L}^{\mathrm{tor}}_{r+1}(\mathfrak {sl}_\ell)$
Authors: Wu Chao‐Zhong , Yang Yi 
Published: February 2025

ABSTRACTStarting from a fairly explicit homogeneous realization of the toroidal Lie algebra via a lattice vertex algebra, we derive an integrable hierarchy of Hirota bilinear equations. Moreover, we represent this hierarchy in the form of Lax equations, and show that it is an extension of a certain reduction of the ‐component KP hierarchy.
Mobile Applications for Hemodialysis: Evaluation Using the Mobile App Rating Scale (MARS)
Authors: Esmaeeli Erfan , Khorashadizadeh Mohadeseh Sadat , Rahmani Meysam 
Published: February 2025

ABSTRACTIntroductionMobile applications (apps) and social media could be useful in improving the condition of patients on hemodialysis. Despite the rise of mobile health apps in hemodialysis management, no research has evaluated the quality of these apps with reliable tools. This study aimed to evaluate the quality of apps designed for the self‐care of patients on hemodialysis.Materials and MethodsA review of Google Play and App Store mobile platforms was carried out to evaluate the mobile apps used for hemodialysis. These apps were assessed using the mobile application rating scale (MARS), which includes criteria for overall quality, engagement, functionality, aesthetics, and information. Search keywords included “Dialysis,” “Kidney Dialysis,” “Hemodialysis,” “Haemodialysis,” and “Peritoneal Dialysis.” Eligibility criteria included being related to dialysis, being designed specifically for patients, being free, being available in English, and being developed for Android and iOS platforms. The included apps were independently evaluated and rated by two reviewers using MARS.ResultsInitially, 177 apps were identified, and after the screening and review processes, six apps were selected for qualitative evaluation. The overall scores on MARS varied from 2.33 to 3.67. The “KidneyPal: Kidney Disease Mgmt” app received the highest scores in most MARS items. Moreover, the maximum app quality mean score belonged to “KidneyPal: Kidney Disease Mgmt” (4.26 out of 5).ConclusionThe findings showed a limited number of apps available for hemodialysis, the majority of which were of low quality. The reviewed apps performed well in functionality but obtained lower scores in terms of app subjective quality. Future studies should focus on developing and testing mobile apps using assessment tools, such as MARS, as well as evaluating their impact on health behaviors and outcomes.
Association analyses reveal both anthropic and environmental selective events during eggplant domestication
Authors: Omondi Emmanuel , Barchi Lorenzo , Gaccione Luciana , Portis Ezio , Toppino Laura , Tassone Maria Rosaria , Alonso David , Prohens Jaime , Rotino Giuseppe Leonardo , Schafleitner Roland , van Zonneveld Maarten , Giuliano Giovanni 
Published: February 2025

SUMMARYEggplant (Solanum melongena) is one of the four most important Solanaceous crops, widely cultivated and consumed in Asia, the Mediterranean basin, and Southeast Europe. We studied the genome‐wide association of historical genebank phenotypic data on a genotyped worldwide collection of 3449 eggplant accessions. Overall, 334 significant associations for key agronomic traits were detected. Significant correlations were obtained between different types of phenotypic data, some of which were not obvious, such as between fruit size/yield and fruit color components, suggesting simultaneous anthropic selection for genetically unrelated traits. Anthropic selection of traits like leaf prickles, fruit color, and yield, acted on distinct genomic regions in the two domestication centers (India and Southeast Asia), further confirming the multiple domestication of eggplant. To discriminate anthropic from environmental selection in domestication centers, we conducted a genotype–environment association (GEA) on a subset of georeferenced accessions from the Indian subcontinent. The population structure in this area revealed four genetic clusters, corresponding to a latitudinal gradient, and environmental factors explained 31% of the population structure when the effect of spatial distances was removed. GEA and outlier association identified 305 candidate regions under environmental selection, containing genes for abiotic stress responses, plant development, and flowering transition. Finally, in the Indian domestication center anthropic and environmental selection acted largely independently, and on different genomic regions. These data allow a better understanding of the different effects of environmental and anthropic selection during domestication of a crop, and the different world regions where some traits were initially selected by humans.
Successful venotomy for portal tumor thrombus removal due to pancreatic carcinoma in a dog
Authors: Hertel Beatrice , Bortolami Elisa , Furlanello Tommaso , Bertolini Giovanna , Cinti Filippo 
Published: February 2025

AbstractObjectiveTo describe a portal venotomy technique and outcome for tumoral thrombus removal in a dog with insulinoma invading the portal vein.Study designCase report.AnimalsA 9‐year‐old entire male West Highland White Terrier.MethodsThe dog was referred for further investigation of recurrent collapsing episodes and weakness. An abdominal ultrasound revealed a pancreatic mass. Biochemical tests were consistent with insulinoma. A dynamic (4D) contrast‐enhanced computed tomography (CT) perfusion study showed a large pancreatic mass originating from the left lobe of the pancreas invading both the portal and splenic veins directly. The portal vein was 80% occluded between the gastroduodenal and splenic vein entry points. The dog underwent partial pancreatectomy, splenectomy, and portal venotomy. Following identification of the thrombus by direct visualization and palpation, Rummel tourniquets were used to isolate the segment of the portal vein, and portal venotomy was performed over the thrombus. The venotomy was repaired with primary closure. Intraoperative hemorrhage was absent following the release of the vascular isolation.ResultsHistopathology was consistent with insulinoma. The dog was discharged 4 days after surgery. Short‐term follow up revealed an absence of postoperative complications. The dog was started on adjuvant therapy, and the re‐examination 3 months after surgery showed an absence of the clinical signs and a good quality of life. One year after surgery, the dog is still alive with confirmed metastatic disease.ConclusionPortal venotomy was successful for thrombus removal and this dog tolerated temporary occlusion of the portal vein well. Careful preoperative CT planning is crucial for good surgical outcomes.
Competitive fitness of bird rape mustard (Brassica rapa L.) that integrated transgenes conferring glyphosate resistance in commercial fields
Authors: Simard Marie‐Josée , Laforest Martin , Martin Sara L. 
Published: February 2025

AbstractTen years after the introduction of genetically engineered canola (Brassica napus L.), bird rape mustard (Brassica rapa L.) with transgenes conferring glyphosate resistance was reported where the crop and the weed were sympatric. Another decade later, populations of these weeds were reported on farms located beyond this initial region of sympatry. To determine if populations with introgressed transgenes have the potential to persist in field borders where wild types and crop plants can be found, the competitive fitness of two of these populations was compared to that of two naturalised wild Brassica rapa populations, a B. rapa cultivar and a B. napus cultivar, in a greenhouse study. Single plants of each of these six Brassica lines (referred to as types) were grown surrounded by four to eight contour plants (1:4 or 1:8) of each type, for a total of 36 combinations, at two densities. The experiment included four replicates and was repeated twice with one trial ending at flowering and the second continuing to plant maturity. Analyses evaluated the effect of Brassica type and density on phenology, total aboveground biomass and seed production as well as gains or losses in these latter fitness components by centre plants compared to contour plants. Results demonstrate that the bird rape mustard populations with transgenes from haphazard crosses with glyphosate‐tolerant B. napus crop plants were not always as fit as other, wild B. rapa populations. Their early development was slower than wild types and their biomass was generally reduced when grown surrounded by dissimilar plant types. Nevertheless, observed differences were unlikely to limit the persistence of these biotypes in the absence of glyphosate application.
Scott analysis, linear orders, and almost periodic functions
Authors: Gonzalez David , Harrison‐Trainor Matthew , “Turbo” Ho Meng‐Che 
Published: February 2025

AbstractGiven a countable structure, the Scott complexity measures the difficulty of characterizing the structure up to isomorphism. In this paper, we consider the Scott complexity of linear orders. For any limit ordinal , we construct a linear order whose Scott complexity is . This completes the classification of the possible Scott sentence complexities of linear orderings. Previously, there was only one known construction of any structure (of any signature) with Scott complexity , and our construction gives new examples, for example, rigid structures, of this complexity. Moreover, we can construct the linear orders so that not only does have Scott complexity , but there are continuum‐many structures and all such structures also have Scott complexity . In contrast, we demonstrate that there is no structure (of any signature) with Scott complexity that is only ‐equivalent to structures with Scott complexity . Our construction is based on functions that are almost periodic but not periodic, such as those arising from shifts of the ‐adic valuations.
Confirmation Bias in Sport Science: Understanding and Mitigating Its Impact
Authors: Beato Marco , Latinjak Alexander T. , Bertollo Maurizio , Boullosa Daniel 
Published: February 2025

Purpose: Confirmation bias, a cognitive phenomenon deeply ingrained in human thinking, shapes our perception of reality. It leads individuals to favor information that aligns with their preexisting beliefs while dismissing or undervaluing the contrary evidence. In sport science, where precision and evidence-based practices are critical aspects to optimize performance, confirmation bias can decisively impact decision-making processes. In this context, practitioners rely on both objective and subjective data to be interpreted to enhance athletic performance. However, confirmation bias introduces a subtle yet powerful distortion, which is difficult to control and quantify. We usually believe that our observations can justify expectations or predictions about future observations, as well as broader generalizations beyond what we have directly observed—inductive inferences. Researchers and practitioners may therefore unknowingly seek out evidence that confirms their beliefs, inadvertently overlooking alternative viewpoints and interpretations. Conclusions: This paper explores the concept of confirmation bias in sport science, providing practical examples in the contexts of testing, training, and monitoring. By understanding how confirmation bias operates (ie, heuristic of decision making), we may develop strategies to mitigate its effects and promote more accurate and effective decision making in sport science (eg, performance).
Declining Physical Education Access in U.S. Schools: A State-by-State Analysis of Policy Implementation
Authors: Kern Ben D. , Wilson Wesley J. , Killian Chad , Paulson Lisa , van der Mars Hans , Woo David , Wallhead Tristan 
Published: February 2025

Purpose: This study evaluated student access to physical education in 26 U.S. states, examining weekly minutes, class sizes, and policy implementation practices. Methods: The U.S. Physical Education and Physical Activity Policy questionnaire was distributed to 40,970 physical education teachers across 26 states. Data were collected on weekly minutes, days/week, class sizes, and policy-related practices. Responses were analyzed to assess physical education access and its correlation with class sizes. Results: Findings revealed that student physical education access is below recommendations, with significant between-state variability. Average weekly minutes were 92.8 in elementary, 151.8 in middle school, 185.9 in high school, and 157.8 for students with disabilities. Positive correlations between minutes/week and class sizes suggest that some schools increase class sizes to maintain instructional time. Conclusion: To address declining physical education access, future efforts should focus on engaging educators and policymakers through advocacy, professional development, and best practices in state policies.