bluuebunny/crossref_metadata_2025_split huggingface dataset:
Climatology and atmospheric conditions of foehn occurrence in the Polish Tatra mountains
Authors: Grajek Zofia , Bednorz Ewa 
Published: February 2024

Abstract

Foehn wind occurrence has generated great interest among researchers because of the destructive power and impact on the local climate. Based on anemometric data provided by a high-mountain station on Kasprowy Wierch in the Polish Tatra Mountains, the characteristics of the potential occurrence of foehn wind (referred to as halny in the Polish Tatras) are presented, including its speed and duration, as well as the frequency of occurrence on
a multiannual, annual and daily basis. Halnywinds occur most frequently in the cold period of the year, with the frequency peaking in November, and sporadically in the summer.
The occurrence of foehn winds is strongly dependent on the synoptic situation. Therefore, the main aim of the study was to identify the circulation conditions conducive to their occurrence on the Polish side of the Tatra Mountains. Circulation conditions responsible for foehn formation were analysed using gridded sea level pressure (SLP) data from the NCEP-DOE (National Centers for Environmental Prediction - Department of Energy) reanalyses. The occurrence of foehn wind in the Tatra Mountains is associated with a low pressure system over north-western Europe, and above normal pressure over south-eastern Europe. The location and intensity of the centres of atmospheric influence on foehn days can vary, as indicated by the three types of pressure systems favouring the occurrence of the phenomenon, distinguished by the hierarchical grouping method.
Optimizing nitrogen rate under single irrigation can maintained a high yield and increased economic benefits in winter wheat
Authors: Bao Xiaoyuan , Guo Congcong , Liu Xuejing , Dai Menglei , Zhang Baoyuan , Ren Jianhong , Gu Limin , Zhen Wenchao 
Published: February 2024

Abstract

Aims
Optimizing winter wheat irrigation and nitrogen fertilizer management is crucial for ensuring sustainable agricultural development in North China Plain (NCP). However, the optimal nitrogen management, especially in single irrigation in spring for winter wheat, is not clear.
Methods
In 2020–2022, we conducted a field experiment to explore the effects of different irrigation levels (W2, irrigated of 75 mm at the spring 3-leaf stage and anthesis stage, respectively; W1, irrigated of 75 mm at spring 4-leaf stage) and nitrogen levels (180, 240, 300 and 360 kg N ha− 1; denoted as N1, N2, N3 and N4, respectively) on grain yield, water consumption and economic efficiency.
Results
The findings demonstrated that W1 reduced evapotranspiration, increased soil water consumption and enhanced water consumption from jointing to anthesis stage. However, W1 irrigation resulted 3.3–11.6% yield loss compared to W2. Adjusting nitrogen fertilizer inputs (300 kg N ha− 1) under W1 can achieves high spike number, flag leaf photosynthetic capacity and harvest index, ultimately resulted in a highest grain yield (8351.5 kg ha− 1). Additionally, W1N3 obtained the highest water use efficiency (20.5 kg ha− 1 mm− 1), irrigation water use efficiency (111.4 kg ha− 1 mm− 1), nitrogen agronomic efficiency (11.2 kg kg− 1), net income and benefit-cost ratio. Based on the water and nitrogen inputs to the yield and economic efficiency model, applying N at 278.8–297.8 kg ha− 1 under W1 conditions achieved 95–100% of the maximum yield and net income.
Conclusions
These results may provide a scientific foundation for optimizing irrigation and nitrogen management and enhancing local farmers’ economic efficiency.
Long-Term Outcomes of Catheter Ablation for Ventricular Arrhythmias: Comparing Techniques with and without Intracardiac Echocardiography - What Matters?
Authors: Lin Mingjie , Ma Chuanzhen , Rong Bing , Zhang Kai , Chen Tongshuai , Wang Juntao , Han Wenqiang , Zhong Jingquan , Wu Lin 
Published: February 2024

Abstract

Background
he increasing use of intracardiac echocardiography (ICE) in the ablation of premature ventricular complexes (PVCs) has raised questions about its true efficacy and safety.
Methods
This retrospective study collected the periprocedural complications and PVC burden post ablation. The risk factors of PVC recurrence was further explored.
Results
The study included patients treated without ICE (control group, n=451) and with ICE (ICE group, n=155) from May 2019 to July 2022. The ICE group demonstrated significantly lower fluoroscopy times and X-ray doses. There were no major complications in the ICE group, and the difference in the occurrence of periprocedural complications between the groups was not statistically significant (p=0.072). The long-term success rates were similar for the control and ICE groups (89.6% and 87.1%, respectively). The origin of PVCs was identified as the independent factor for ablation success.
Conclusions
The use of ICE did not confer an advantage with regard to long-term success in PVCs ablation. To thoroughly evaluate the safety and effectiveness of ICE in PVCs ablation, a prospective, multicenter, randomized study is warranted.
Inhibition of purine metabolism promotes the differentiation of the neuroblastoma driven by MYCN
Authors: Jiang Yufeng , Xiao Hui , Yang Yi , Zhang Yingwen , Wu Xiaoyu , Zhang Qi , Huang Qingyi , Gao Hongxiang , Han Yali , Zhang Anan , Jiang Dapeng , Zheng Liang , Li Yanxin , Gao Yijin 
Published: February 2024

Abstract

Background: Neuroblastoma is the common extracranial solid tumor in children, with a poor prognosis for high-risk patients. MYCN amplification is the most important molecular biomarker in the high-risk category. For MYCN’s “undruggable” properties--lack of enzymatic pocket for conventional small molecules to bind and inaccessibility for antibodies due to the predominant nucleus localization of MYCN, current therapeutic strategies have not significantly improved. It is known that MYCN can affect a variety of tumor metabolism and is closely related to tumor differentiation. The objective of this study is to investigate the impact of purine metabolism on the maintenance of stemness in MYCN high-risk neuroblastoma and identify potential small molecule inhibitors that can enhance the differentiation of neuroblastoma cells.
Methods: Metabolic mass spectrometry data were used to analyze the differences in metabolites between neuroblastoma cell lines with high and low MYCN, and key metabolic enzymes were analyzed in conjunction with public RNA databases. Different neuroblastoma cell lines were treated with the small molecule inhibitor for cell differentiation, proliferation, colony formation, and cell migration analysis, to find inhibitors that are promotive for cell differentiation and validate them in vivo and in vitro.
Results: In our study, we found significant changes in nucleotide metabolism in NB cell lines with high MYCN compared to those with low MYCN. The expression of purine metabolic enzymes was positively correlated with MYCN expression, prognosis, and differentiation status in neuroblastoma. The small molecular lometrexol, a phosphoribosylglycinamide formyltransferase (GART) inhibitor, which blocks the de novo pathway of purine metabolism, can promote a pro-differentiation effect on neuroblastoma cells through in vivo and in vitro experiments and inhibit tumorigenesis.
Discussion: Our study suggested that lometrexol, the small molecule inhibitor of nucleotide metabolism, may contribute to improving treatment strategies for pediatric neuroblastoma, enhancing patient prognosis, and improving overall quality of life.
Anaerobic Co-Digestion of Swine Manure and Hydrolyzed Swine Carcasses at Two Different Biodigesters
Authors: Silva João Fernando Ferri da , Tápparo Deisi Cristina , Antes Fabiane Goldschmidt , Steinmetz Ricardo Luís Radis , Kunz Airton 
Published: February 2024

Abstract
This study compared the anaerobic co-digestion of hydrolyzed swine carcasses and swine manure at different organic loading rates (OLRs) in two different biodigesters, a covered lagoon biodigester (CLB) and a continuous stirred tank reactor (CSTR). The OLR progression in the CSTR had increments of about 0.5 gVS L-1 d-1 over five different operating phases (160 days). The best performance was obtained with an OLR of 2.09 gVS L-1 d-1 and a methane productivity (MP) of 1.12 LN CH4 Lreactor-1 d-1. A high concentration of total ammonia nitrogen (TAN), mainly in the form of free ammonia (FA), resulted in inhibition of methanogenic activity, with volatile fatty acids (VFA) accumulating in the biodigester. In CLB, the OLR progressions was increased by approximately 0.08 gVS L-1 d-1 per phase over nine phases (260 days), with the best performance in OLR of 0.63 gVS L-1 d-1 and MP at 0.31 LN CH4 Lreactor-1 d-1. CLB was stable throughout most of the experiment, even at high OLRs. Despite the good MP, the CLB showed instability in the last two phases, where a significant increase in pH and FA concentration was observed. It can be concluded that the use of hydrolyzed swine carcasses in co-digestion with manure has a high potential for CH4 production. Although the TAN and FA concentrations had a significant effects on the process, the biodigesters performed satisfactorily.
A Game theory based Intrusion detection system for low constrained IoT devices.
Authors: Ambarkar Smita Sanjay , Shekokar Narendra 
Published: February 2024

Abstract
Through shady networks, heterogeneous devices are connected to build the Internet of Things (IoT). However, protecting an IoT network is of the utmost significance. The best option for protecting IoT networks is cryptography. Encrypting every piece of data is not desired, though, as it places a heavy computational burden on IoT devices with limited processing power. As a viable alternative, anomaly-based intrusion detection systems offer a way to secure low constraint devices. The majority of recent research has suggested employing energy- and computationally-intensive machine learning algorithms for IDS. The lack of a defined framework for recognising the attack is another challenge for machine learning-based intrusion detection systems (IDS), which must repeatedly train for each new attempt. This research suggests an energy-saving and false-positive rate-lowering IDS that is based on game theory. The suggested IDS offers a mathematical framework for attack detection. Furthermore, as the proposed IDS is only triggered in response to the appearance of a new attack signature, the system is appropriate for devices with low constraints.
Ammonium vanadate doped by hydrated manganese divalent ions for high-performance zinc-ion batteries
Authors: Hu Jidong , Li Yali , Shen Sijin , Dong Yunxia , Li Donghao , Chen Yongchao , Fu Yujun , He Deyan , Li Junshuai 
Published: February 2024

Abstract
Vanadium-based materials are considered as promising cathode materials in aqueous zinc-ion (Zn2+) batteries (AZIBs) because of their abundant valence states and adjustable ion diffusion channels. However, the slow kinetics of the Zn2+ intercalation and the instability of the layered structure during long cycle are the bottlenecks restricting their further development. In this paper, the hydrated manganese divalent ions (Mn2+) are introduced into ammonium vanadate (NH4V4O10) to partly replace the NH4+ ions to prepare a high-performance AZIB cathode. After doping hydrated Mn2+, the interlayer spacing of NH4V4O10 is enlarged, providing a broadened channel for the diffusion of Zn2+ accordingly. The results reveal that the electrode with the optimal doping quantity has a very high discharge capacity (539.4 mAh g−1 at 0.2 A g−1) and excellent cyclic stability (85.3% retention of the initial capacity after 3000 cycles at 5 A g−1). A highly competitive energy density of 378 Wh kg−1 at 362 W kg−1 is delivered by the corresponding AZIB. Moreover, this method is a general and effective strategy for developing high-performance AZIB cathode materials, as demonstrated by the consistent crystal structure and stable cycling properties for NH4V4O10 doped with other transition bivalent metal cations.
Structural Basis for Expanded Substrate Specificities of Human Long Chain Acyl-CoA Dehydrogenase and Related Acyl- CoA Dehydrogenases
Authors: Narayanan Beena , Xia Chuanwu , McAndrew Ryan , Shen Anna L. , Kim Jung-Ja P. 
Published: February 2024

Abstract

Crystal structures of human long-chain acyl-CoA dehydrogenase (LCAD) and the E291Q mutant, have been determined. These structures suggest that LCAD harbors functions beyond its historically defined role in mitochondrial β-oxidation of long and medium-chain fatty acids. LCAD is a homotetramer containing one FAD per 43kDa subunit with Glu291 as the catalytic base. The substrate binding cavity of LCAD reveals key differences which makes it specific for longer and branched chain substrates. The presence of Pro132 near the start of the E helix leads to helix unwinding that, together with adjacent smaller residues, permits binding of bulky substrates such as 3α, 7α, l2α-trihydroxy-5β-cholestan-26-oyl-CoA. This structural element is also utilized by ACAD11, a eucaryotic ACAD of unknown function, as well as bacterial ACADs known to metabolize sterol substrates. Sequence comparison suggests that ACAD10, another ACAD of unknown function, may also share this substrate specificity. These results suggest that LCAD, ACAD10, ACAD11 constitute a distinct class of eucaryotic acyl CoA dehydrogenases.
Contrasting the potential range changes of Curculio davidi (Fairmaire) under future climate change in China
Authors: Wang Zhuoyuan , Zhuo Zhihang , Ali Habib , Li Xiushan , Xu Danping 
Published: February 2024

Abstract

Curculio davidi (Fairmaire) is found in all chestnut producing regions of the world and is a major fruit pest of chestnuts. In this work, the MaxEnt software was adopted to simulate the potential distribution of C. davidi in China under 19 bioclimatic variables. The mean AUC of the model was 0.988. Meaning that the predictions were extremely accurate and reliable. Research has shown that the current C. davidi highly suitable area has been 65251 km2, accounting for 0.68% of the total area of China. The area of moderate suitable areas under different future scenarios (SSP1-2.6, SSP2-4.5, SSP5-8.5) increased by 22.12%-27.33% (2050s) and 17.80%-38.22% (2080s) compared with the existing distribution, and the area of highly suitable areas has been showing a trend of shrinking. The re-sults of the study showed that 6 climate factor variables, prec7, bio18, bio4, bio15, bio10, and prec5, contributed to the distribution of C. davidi. The jackknife test was used to determine the percentage contribution of six climatic factors affecting the distribution of C. davidi as prec7 (42.3%), bio18 (22.3%), bio4 (21.7%), bio15 (7.2%), bio10 (4.1%), prec5 (2.3%). This study has provided a reference for the scope and accuracy of pest control in C. davidi. It also offered a basis for how to take measures to control the spread of this pest as soon as possible under the back-ground of rapid climate change.
Clinical values of percutaneous peri-pancreatic drainage for management of blunt traumatic pancreatic neck transection in adult patients
Authors: Xia Weiliang , Shen Chanjuan , Shen Yan 
Published: February 2024

Abstract
Purpose
Surgical resection or surgical peri-pancreatic drainage was recommended for patients with blunt traumatic pancreatic neck transection. Peri-pancreatic drainage could be also achieved percutaneously, termed as percutaneous peri-pancreatic drainage (PPPD) in this study. The clinical values of PPPD for patients with blunt traumatic pancreatic neck transection were evaluated in this study.
Methods
Patients with blunt traumatic pancreatic neck transection treated by either surgical resection (n = 5) or PPPD (n = 13) were enrolled in this study, pancreas-related events and prognosis were compared between the surgical resection group and the PPPD group.
Results
The patients of surgical resection and PPPD groups were comparable in background characteristics except for the concomitant abdominal injuries (60% in the surgical resection group and 7.7% in the PPPD group, P = 0.044). The rates of post-operative pancreatic fistula (POPF) and mortality of the surgical resection group are both 20%. All the 13 patients in PPPD group discharged with the external drainage tube which were removed successfully in 12 (92.3%) patients in whom the drainage tube maintenance was 3.0 (2.8, 4.0) months. PPPD was failed in 1 (7.7%) patient who received Roux-en-Y anastomosis between the jejunum and the thickened fistula wall successfully. Three (3/12, 25%) patients developed main pancreatic duct stricture as a long-term complication of PPPD management.
Conclusions
PPPD could be performed safely and effectively for blunt traumatic pancreatic neck transection patients. Delayed internal drainage can be used as a salvage treatment in the case of failed PPPD. Main pancreatic duct stricture is the long-term complication of PPPD management.
Detection and identification of Ephedra Herba seed pests based on X-rays and DNA barcodes
Authors: xiao xiaohouhong , Guo Yuan-Ru , Zhang Ling-Yu , Luo Lu , Wu Wen-Guang , Gao Ji-Hai , Xu Fan , Cao Gang , Shang Wei , Hu Hao-Yu , Xu Jiang , Chen Shilin 
Published: February 2024

Abstract
As an important natural medicinal resource for humans, Ephedra sinica Stapf often suffers from various biological stresses during its growth process. One of the pests that pose a threat to Ephedra is the Ephedra seed pest. Its primary mode of damage is laying eggs inside the Ephedra seeds, where they develop and eventually emerge as adult wasps, causing significant damage to the seeds. This study aimed to investigate the effectiveness of X-ray for Ephedra seed pest detection, the impact on the use value of Ephedra seeds infested by pests, and the further confirmation of pest species information. The mature Ephedra seeds from the Inner Mongolia Autonomous Region were taken as the teste object. The results showed that the germination rates of three different batches of seeds were 46%, 40%, and 38%, while the seedling emergence rates were only 36%, 30%, and 32%, respectively, significantly lower than that of control healthy seeds 66% and 52%. The phylogenetic tree Neighbor-Joining (NJ) was constructed by extracting the COI sequences of the pest samples, and was identified as a new species of Eurytoma genus based on morphological characteristics. X-ray detection is a commonly used, non-invasive method. Based on non-destructive X-ray testing, the quality of Ephedra seeds could be classified into three types: healthy plump seeds, seeds infested by pests, and underdeveloped hollow seeds. In conclusion, the combined use of X-ray and DNA barcoding methods can achieve rapid and accurate detection and identification of E. sinica seed pests, which is of great significance for the management and control of Ephedra seed production.
A Novel Classification of Posterior Pelvic Exenteration to Assess Prognosis in Female Patients with Locally Advanced Primary Rectal Cancer: A Retrospective Cohort Study from China PelvEx Collaborative
Authors: Li Yuegang , Zhuang Meng , Hu Gang , Zhang Jinzhu , Qiu Wenlong , Mei Shiwen , Tang Jianqiang 
Published: February 2024

Abstract

Purpose
Surgical techniques and the prognosis of posterior pelvic exenteration for locally advanced primary rectal cancer in female patients pose challenges that warrant additional assessment. Therefore, we compared short-term and survival outcomes of posterior pelvic exenteration in female patients using a novel Peking classification.
Methods
We retrospectively analysed a prospective database from China PelvEx Collaborative in three tertiary referral centres. A total of 172 patients who underwent combined resection for locally advanced primary rectal cancer were classified into four subtypes (PPE-I [64/172], PPE-II [68/172], PPE-III [21/172], and PPE-IV [19/172]) according to the Peking classification; perioperative characteristics and short-term and oncological outcomes were analysed.
Results
Differences were significant among the four groups regarding colorectal reconstruction (p < 0.001), vaginal reconstruction (p < 0.001), in-hospital complications (p < 0.05), and urinary retention (p < 0.05). The R0 resection rates for PPE-I, PPE-II, PPE-III, and PPE-IV were 90.6%, 89.7%, 90.5%, and 89.5%, respectively. The 5-year overall survival rates of the PPE-I, PPE-II, PPE-III, and PPE-IV groups were 73.4%, 68.8%, 54.7%, and 37.3%, respectively. Correspondingly, their 5-year disease-free survival rates were 76.0%, 62.5%, 57.7%, and 43.1%, respectively. Notably, PPE-IV demonstrated the lowest 5-year overall survival rate (p < 0.001) and 5-year disease-free survival rate (p < 0.001).
Conclusion
The Peking classification can aid in determining suitable surgical techniques and conducting prognostic assessments in female patients with locally advanced primary rectal cancer.
Calibration of the contact parameters for soybean-bonded particle model based on DEM
Authors: Han Dandan , Wang Qing , Tang Chao , Li Wei , Xu You 
Published: February 2024

Abstract

To retrieve the simulation contact parameters of the soybean-bonded particle for an effective gas-solid two-phase flow coupling simulation analysis of the working procedure of the pneumatic seed-metering device, the angle of repose (AoR) and angle of stacking (AoS) from the physical seed-piling test were captured as the evaluation indexes. The Plackett-Burman test and the steepest ascent test were ratified to simplify the simulation analysis of the soybean-bonded particles, screening out the crucial influenced factors and centroids. The Box-Behnken response surface test was then implemented to identify the desired saliency factor values, and the universality of the calibrated contact parameters for soybean-bonded particles synthesized with varying fraction particle sizes was eventually confirmed. The results revealed that the effect of the static friction coefficient of soybean-plexiglass (µp−g) on AoR was exceedingly significant, and that of the static and rolling friction coefficients of soybean-soybean (µp−p & Cp−p) was generally prominent. While it was abundantly clear that both µp−p and Cp−p supremely affected AoS. The optimal values determined by the Box-Behnken response surface test yielded ideal values of 0.0678 for µp−p, 0.2453 for µp−g, and 0.0079 for Cp−p, culminating in an AoR of 28.32° and AoS of 28.76°, respectively. Based on the derived optimal simulation contact parameters, the maximal error between the simulated and measured values of AoR and AoS of soybean-bonded particles constructed with various fraction particle sizes was estimated to be 1.59%, implying that the calibrated contact parameters have a superior generality. The insights of this investigation can be effectively applied to the coupled simulation analysis of the pneumatic soybean seed-metering device’s operations, as well as a reference for other researchers to erect particle models for DEM simulation using the bonded particle method.