bluuebunny/crossref_metadata_2025_split huggingface dataset:
Atypical herpes zoster in a patient with AIDS
Authors: Fernández‐Díaz M.L. , Herranz P. , de Lucas R. , González‐García J. , Suárez‐Marrero M.C. , Contreras F. , Casado M. 
Published: July 2006

AbstractObjective To report a case of persistent infection by varicella‐zoster virus (VZV) in an HIV‐infected patient who presented with atypical, hyperkeratotic viral lesions and a partial response to acyclovir.Methods Viral changes found on histopathological examination; definitive diagnosis of VZV infection was established by viral culture.Results Lesions of chronic hyperkeratotic herpes zoster responded partially to acyclovir therapy, and complete resolution was achieved with intravenous foscarnet. Absence of visceral involvement.Conclusion Prolonged acyclovir therapy for herpes virus infections in HIV‐seropositive patients may represent an important pathogenic factor for the appearance of atypical clinical forms associated with drug‐resistant viral strains.
Raised galactose plus galactose‐1‐phosphate blood levels in patients under PUVA therapy
Authors: Schulpis Kleopatra H. , Georgala Sophia , Michas T. , Papakonstantinou E.D. , Chadjidakis J. , Kalogerakou M. , Stratigos J. 
Published: July 2006

AbstractBackground PUVA has become a preferred method of treatment for vitiligo and psoriasis. However, 8‐methoxypsoralen (8‐MOP) as well as a high galactose diet may cause liver and kidney function damage and enhance cataract formation.Patients and Methods Twenty one patients aged 32 ± 2.6 yrs with vitiligo (N= 11) or psoriasis (N= 10) underwent eye‐examination, liver and kidney function tests and galactose + galactose 1‐phosphate (gal + gal P) blood evaluation using Porton‐Cambridge Ltd reagents, before and after the 12th PUVA treatment during a 35–40 day study.Results All these functional tests including eye‐examination were normal before and after commencing therapy. However, the mean gal + gal P blood levels (1.29 ± 0.41 mg/dl) were statistically elevated (2.95 ± 0.42 mg/dl) at the end of the study. It is suggested that 8‐MOP either impairs liver function or acts as an inhibitor of the enzymes responsible for galactose metabolism. We propose gal + gal P blood estimation in all patients before and, at intervals, after the initiation of PUVA therapy in order to prevent as early as possible an additional risk factor for liver or kidney dysfunction as well as cataract formation.
Acute myelomonocytic leukemia revealed by a chickenpox‐like rash
Authors: Hoen Bruno , Neidhardt Anne C , Aghassian Catherine , Dorvaux Véronique , Witz Francis , Canton Philippe 
Published: July 2006

AbstractAn unusual case of leukemia cutis is presented. A 42‐year‐old man presented with a vesicular skin rash mimicking chickenpox. Skin biopsy firmly ruled out the diagnosis of varicella and revealed an infiltration of the superficial derma by myeloblasts. Bone marrow aspirates confirmed the diagnosis of acute myelomonocytic leukemia (type M4).
Pruritic urticarial papules and plaques of pregnancy (PUPPP): a clinicopathological review of 35 patients
Authors: Powell Frank C. , Dervan Peter , Wayte Jeffrey , O'Loughlin Sean 
Published: July 2006

AbstractThe clinical features of 35 cases of Pruritic Urticarial Papules and Plaques of Pregnancy (PUPPP) seen over an 8 year period were reviewed with regard to age and gestational stage of onset, evolution and severity of disease and response to therapy. The histologic features in biopsies from 15 patients were analysed for pattern and extent of inflammatory change and the composition of the inflammatory cells were studied with a panel of monoclonal antibodies. This study confirmed PUPPP to be a well defined clinical entity mainly occurring in young primagravidas in the third trimester and usually responsive to topical treatments. Histologically, perivascular upper and mid‐dermal inflammatory changes were present in all biopsies with epidermal spongiosis and vesiculation a prominant feature in many cases. The inflammatory infiltrate was composed of an admixture of T lymphocytes and macrophages.
Cyclosporin A in the treatment of cutaneous vasculitis. Clinical and cellular effects
Authors: Tosca A.D. , Ioannidou D.J. , Katsantonis J.C. , Kyriakis K.P. 
Published: July 2006

AbstractBackground Treatment of cutaneous vasculitis(CV) is an unsettled issue. Cyclosporin A (Cy‐A) has been successfully used in dermatoses with immunologic background. some systemic vasculitides and Behcet's disease.Objective To check the therapeutic potential of Cy‐A in severe or recalcitrant cases of CV was considered of interest. The effects on the in situ cell populations involved in the inflammatory‐immune events were further investigated.Methods An open clinical trial (12 cases) was carried out. An immunohistochemical study was also performed, evaluating skin specimens from established lesions, before and 48 h after Cy‐A first administration. The effect on endothelial adhesion molecules, integrin bearing leukocytes, T‐cells, lymphomononuclear cells and dendrocytes in the dermis as well as on epidermal antiyenic determinants focused our interest.Results Reduced endothelial ICAM‐1 expression was shown. Cy‐A was proved to adversely affect b2 integrin expression and therefore adhesion pathways. T‐cells, epidermal dendritic cells and dendrocytes were found decreased. On clinical grounds, a very early therapeutic response was noted. Tolerance was good in the dose of 5mg/kg/day. Relapses, however, have not been avoided.Conclusion Cy‐A seems to be very effective on both the clinical and cellular level where inflammatory‐immunologic events seem to be temporarily inhibited.
Pityrosporum ovale and seborrhoeic dermatitis in HIV‐seropositive and HIV‐seronegative men. Quantitative cultures and serological studies
Authors: Bergbrant Ing‐Marie , Faergemann Jan , Voog Ewa , Löwhagen Gun‐Britt 
Published: July 2006

AbstractBackground Previous studies of quantitative determinations of Pityrosporum ovale in HIV‐seropositive patients with and without seborrhoeic dermatitis are contradictory.Objective To investigate the number of P. ovale among HIV‐seronegalive and HIV‐seropositive men using contact plates containing cow's milk as the main lipid source and to analyse sera with ELISA for IgG antibodies to a P. ovale protein extract.Results There was no difference in the number of P. ovale between healthy controls and HIV‐positive patients with and without seborrhoeic dermatitis. HIV‐seropositive patients had significantly lower IgG antibody litres to a P. ovale protein extract compared with healthy individuals.
Comparative effects of two different calcipotriol (MC 903) cream formulations versus placebo in psoriasis vulgaris. A Randomised, Double‐Blind, Placebo‐Controlled, Parallel Group Multi‐Centre Study1
Authors: Harrington Christine I. , Goldin David , Lovell Christopher R. , Van de Kerkhof Peter , Nieboer Cees , Austad Joar , Molin Lars , Clareus Birgitta Wilson , Rask‐Pedersen Eva 
Published: July 2006

AbstractBackground Calcipotriol ointment is an effective treatment For psoriasis vulgaris. Although cream formulations have a less emollient effect they are often more acceptable to patients.Objective To compare calcipotriol 50 μg/g in two different cream formulations with vehicle in patients with psoriasis vulgaris.Method A randomised, double‐blind, parallel group, multi‐centre, comparison of cream A in which calcipotriol 50μg/g is dissolved, cream B in which calcipotriol 50 μg/g is suspended as tine particles and vehicle. A 2‐week wash‐out period was followed by 8 weeks double‐blind treatment.
Papular‐purpuric “gloves and socks” syndrome
Authors: Martins César , Gonçalo Margarida , Mariano Angelina , Baptista A. Poiares 
Published: July 2006

AbstractPapular‐purpuric “gloves and socks” syndrome is a recently isolated acute self resolving disease. It is characterised by symmetrical cutaneous lesions on the hands and feet, with a sharp limit at the wrists and ankles, presenting a gloves and socks look. Lesions begin as a pruritic oedema and erythema and turn purpuric. Oral mucosal lesions, high fever and arthralgia are also present. Parvovirus B19 has been implicated in this exanthematic disease in about 50% of the cases. We recently observed two typical cases of this syndrome; only one patient had serologic evidence of recent infection by Parvovirus B19.
Acquired idiopathic cutaneous elastolysis of the papillary and mid‐dermis: distinct but related conditions. Report of two cases
Authors: Betti Roberto , Inselvini Elena , Crosti Carlo 
Published: July 2006

AbstractAmong the acquired idiopathic cutaneous elastolytic disorders, pseudoxanthoma elasticum‐like papillary dermal elastolysis (PDE) and mid‐dermal elastolysis (MDE) are conditions not frequently reported in the literature.We report 2 cases: the first an older woman with typical papular and plaque‐like lesions on both sides of her neck and shoulders and the second a 42‐year‐old woman with fine wrinkles scattered all over the Hunk, shoulders and abdomen. Histological examination of the first case revealed loss of the elastic fibers limited to the papillary dermis, instead in the second case the loss was observed in the mid‐dermis.We discuss the possibility that PDE and some cases of mm‐inflammatory MDE may represent distinct but related entities in a “spectrum” of acquired elastolysis and that they may be an expression of intrinsic aging.
Acquired perforating folliculitis in chronic renal failure: report of two cases
Authors: Bianchi Luca , Innocenzi Daniele , Iraci Stefano , Zicari Luigi 
Published: July 2006

AbstractBackground Patients with chronic renal failure, regardless of its cause, with/without hemodialysis/peritoneal dialysis, showed cutaneous alterations. Two patients had a follicular hyperkeratotic papular eruption, with clinical and histological features of perforating folliculitis.Methods A dermatological examination and multiple skin biopsies were done.Results We diagnosed acquired perforating folliculitis in two chronic renal failure patients on hemodialysis. The lesions were located predominantly on the lower extremities with hyperkeratotic papules and small nodules. Microscopically, the papule always affected the follicular structure. The follicle was widely dilated and packed with keratotic material, necrotic debris and degenerated basophilic coarse connective fibers passing which passed through follicular perforations.Conclusion Acquired perforating folliculitis is a cutaneous manifestation in chronic renal failure, with/without hemodialysis treatment, that can mimic essential primary perforating folliculitis. Transepidermal elimination mechanisms and the distinction between primary and acquired perforating dermatoses arc discussed.
The genetic epidemiology and autoimmune pathogenesis of alopecia areata
Authors: McMichael Amy J. 
Published: July 2006

AbstractUnlit recently, there was only circumstantial evidence to support the autoimmune and genetic etiology of alopecia areata. The advent of HLA stereotyping and linkage analysis has revealed an increase in specific HLA alleles in patients with alopecia areata and controls. Even more current is the detection of autoantibodies to the hair follicle in the sera from humans with alopecia areata and laboratory animal models of the disease. Recent experiments suggest that there may even be specific HLA class II alleles that play a protective role against the development of alopecia areata. Herein, the circumstantial data and the confirmed linkage data to support a genetic/autoimmune interplay theory of alopecia areata are discussed. The temporal advancements of research in the area of the HLA typing are reviewed for the disease.
Lymphangioma and lymphangiectasis of the vulva
Authors: Virgili A. , Corazza M. 
Published: July 2006

AbstractBackground Lymphangioma circumscriptum and lymphangiectasis are uncommon in the vulvar area.Patients Three cases of lymphangiectasis and one case of Lymphangioma circumscriptum affecting the vulva are reported. While the lymphangiectasis arose after hysterectomy, vulvectomy and lymphadenectomy, respectively, no causes were found in the woman affected by Lymphangioma circumscriptum. All four cases were treated with diathermocoagulation and cryotherapy without recurrence.Conclusions Lymphangiomas and lymphangiectasis share similar clinical and pathological features but have different etiopathogenesis. Lymphangioma may be congenital while lymphangiectasis is always secondary to chronic lymphedema due to infective, obstructive and neoplastic diseases. Misdiagnosis and confusion with other more common pathologies is probably the cause of the apparent rarity of these lymphatic disorders.
Selective heat therapy in cutaneous leishmaniasis: a preliminary experience using the 585 nm pulsed dye laser
Authors: Meawad Osama B. 
Published: July 2006

AbstractAim The purpose of this paper is to examine the effect of the yellow pulsed dye laser on the natural history of cutaneous leishmaniasis (CL).Materials and methods A 31 year old Saudi patient suffered from CL due to L. tropica. He was treated with 585 nm. 450 μs flashlamp pulsed dye (FLPD) laser. The patient received two laser sessions, 2 weeks apart using 5 mm spot size with a fleunce range of 8–8.5 J/cm2.Results The lesion healed completely within 6 weeks with hyperpigmentation. At 16 weeks, the skin exhibited excellent texture with no scarring or recurrence.Discussion The ability to achieve a high temperature at structures or individual cells with minimal injury in healthy tissue and/or selective destruction of superficial dermal capillaries may in theory explain the possible efficacy of FLPD laser in CL. However, the exact mechanism(s) remains unknown.Conclusion The use of FLPD laser may promise local, practical, and a safe alternative form of heat therapy in CL. It has a unique advantage of possible scar improvement. Further extensive well‐controlled studies are indicated.
Diagnosis and therapy of intraurethral condylomata acuminata
Authors: Ritschel Susanne , Heimbach Dirk , Brühl Peter 
Published: July 2006

AbstractBackground Condylomata acuminata is one of the commonest sexually transmitted diseases. The urethra is involved in up to 30% of cases.Case report A case of intraurethral condylomata acuminata is presented as an illustration of diagnosis and therapy.Comment Meatoscopy allows direct visualisation of meatal condylomata. Ascending urethrogram or contrast voiding cysturethrography can show filling defects suspicious of condylomata acuminata: urethroscopy is diagnostic. In the author's opinion, laser therapy is the treatment of choice.
Women with clinically significant hirsutism always have detectable endocrinological abnormalities
Authors: Al‐Khawajah Marwan M. , Fouda Neel Mona A. 
Published: July 2006

AbstractAim In this study a consecutive series of 120 hirsute Saudi women were thoroughly investigated fur possible causes of their hirsutism.Methods In addition to a detailed clinical evaluation the following hormones were measured: testosterone, free testosterone, dehydroepiandrosterone sulphate, prolactin, progesterone, luteinising hormone, follicle stimulating hormone, thyroid stimulating hormone. T3, T4, cortisol, 17‐hydroxyprogesterone, androstenedione and dihydrotestosterone.Results All evaluate patients had at least one hormonal abnormality and 85.9% had at least one of the five major androgens elevated. Polycystic ovaries were found in 59% of the patients, hyperprolactinaemia in 34.6%, and 14.1% had congenital adrenal hyperplasia.Conclusion We recommend a two‐step laboratory work‐up that will unravel a cause for hirsutism in most if not all hirsute women.
A statistical analysis of the characteristics of pigmented skin lesions using epiluminescence microscopy
Authors: Dellino M. , Fabbrocini G. , Argenziano G. , Magliocchetti N. , Nofroni I. 
Published: July 2006

AbstractDue to the fact that not all pigmented skin lesions (PSL) can be diagnosed solely by their clinical appearance, additional criteria are required to optimize the clinical diagnosis of atypical nevus and melanoma. Epiluminescence microscopy is a non‐invasive in vivo examination that often helps to improve the accuracy of clinical diagnosis of such lesions. Years of experience have indicated some differential epiluminescent patterns for benign and malignant PSL but there is some controversy about certain borderline lesions for which histological examination is always necessary. In our study we performed a statistical analysis of data concerning 183 PSL to determine characteristics significantly associated with these lesions allowing identification of epiluminescent criteria suggestive of atypical nevus and malignant melanoma. Using the chi‐quadro test and stepwise regression logistic model, we identified the following epiluminescent pattern as a risk factor for atypical nevus and malignant melanoma: irregular pigment network, presence of capillaries, irregular and abrupt ending of overall pigmentation, irregular brown globules and irregular shape and size of black dots.
Carcinoma erysipeloides of the breast: two case reports
Authors: Virgili Annarosa , Maranini Chiara , Malfa Vilma La 
Published: July 2006

AbstractCarcinoma erysipeloides (CE) is an uncommon cutaneous metastasis of breast carcinoma; it may be confused with erysipelas and other inflammatory lymphedemas. We report two cases of CE in women previously treated by mastectomy for ductal invasive carcinoma, CE is the clinical manifestation of dissemination of neoplastic cells in the cutaneous lymphatic vessels: thus it has a very poor prognosis despite all therapies.
Anti-Nepotism's Ghost: Attitudes of Administrators Toward Hiring Professional Couples
Authors: Pingree Suzanne , Butler Matilda , Paisley William , Hawkins Robert 
Published: July 2006

Laws and policies are often the formalization of attitudes. The attitudes that originally led to the policy continue even when the policy no longer exists. We felt the anti-nepotism policies, declared discriminatory by HEW's Office of Civil Rights, were still in effect in the attitudes of college and university faculty. To test this, we surveyed the chairpersons of departments of psychology and sociology concerning their attitudes toward hiring a professional couple in their department. Responses to the question “Overall, how likely is it you would support the hiring of a professional couple?” indicated opposition by 37% of the chairpersons, neutrality by 25%, and support by 38%. When asked to list comments under four headings—advantages to department, disadvantages to department, professional advantages to couple, and professional disadvantages to couple—we found that supporters were more likely than opposers to mention advantages to the department and to the couple and that opposers were more likely than supporters to mention disadvantages to the department and to the couple. The types of comments made by the chairpersons may be useful to academic couples wishing to work together. “When James J. Gibson, a psychologist, moved from Smith College to Cornell University in 1948, his wife, Eleanor, also a psychologist, applied for a teaching job in her husband's department. Sixteen years later, she was hired.… “When Janet Taylor Spence went to the University of Texas in 1964, she had to forego teaching in the psychology department because her husband was already employed there. Instead she moved into the educational psychology department… In 1967 her husband died and she moved into the psychology department. A year later, she was named department chairman.”
Matrix Of Tensions: A Model of Mothering
Authors: Oberman Yael , Josselson Ruthellen 
Published: July 2006

Questions about how women integrate maternity into their sense of self have generated a quest for an heuristic model. We suggest that mothers struggle to balance themselves amid a set of polarities/tensions and that mothering can be situated within a phenomenological matrix of such tensions. We propose a model that includes the following developmental issues: loss of self/expansion of self; omnipotence/liability; life-destroying/life-promoting behavior; maternal isolation/maternal community; cognitive strategies/intuitive responses; maternal desexualization/ maternal sexualization. Investigation and understanding of how mothers cope with these tensions could yield insights into both universal and particular aspects of mothering. I held him so and rocked him. I cradled him. I closed my eyes and leaned on his dark head. But the sun in its course emerged from among the water towers of down-town office buildings and suddenly shone white and bright on me. Then through the short fat fingers of my son, interred forever, like a black and white barred king in Alcatraz, my heart lit up in stripes. — Grace Paley, The Little Disturbances of Man
Reinventing The Cycle: Two Views Of The Psychology Of Domestic Violence
Authors: Crowley Joan E. 
Published: July 2006

The Domestic Assault of Women: Psychological and Criminal Justice Perspectives. Revised and Expanded Edition, Donald G. Dutton. Vancouver, British Columbia, Canada: UBC Press, 1995. 337 pp., $22.95 (paper), ISBN: 0-7748-0462–9. Loving to Survive: Sexual Terror, Men's Violence, and Women's Lives. Dee L. R. Graham with Edna I. Rawlings and Roberta K. Rigsby. New York: New York University Press, 1994. 321 pp., $35.00 (cloth), $17.95 (paper), ISBN: 0-8147-3058–2.
Practice and Research: Two New Books on Rape
Authors: Ryan Kathryn M. 
Published: July 2006

Intimate Betrayal: Understanding and Responding to the Trauma of Acquaintance Rape, Vernon R. Wieheand Ann L. Richards. Thousand Oaks, CA: Sage, 1995. 214 pp., $19.95 (paper), ISBN: 0-8039-7361-6; $45.00 (cloth), ISBN: 0-8039-7360-8. Attitudes Toward Rape: Feminist and Social Psychological Perspectives, Colleen A. Ward. London: Sage, 1995. 232 pp., $19.95 (paper), ISBN: 0-8039-8594-0; $65.00 (cloth), 0-8039-8593-2.
Extra‐Cutaneous Melanin
Authors: BREATHNACH A.S. 
Published: July 2006

Extra‐cutaneous melanocytes derive from either the neural crest, the outer wall of the optic cup, or the cranial neural tube. Those of neural crest origin reach most bodily regions, and may give rise to primary melanoma in various tissues. The Kupffer cell produces a form of melanin, but is hardly a melanocyte. Melanocytes of the internal ear may be concerned with secretion of endolymph, trans‐epithelial ion transport, and with protection against ototoxic drugs and high‐intensity noise damage. There is evidence from albino animals that retinal pigment epithelium determines co‐ordinates of the neural retina, and its decussation pattern during development.Neuromelanin derives from Dopamine, and is found in dopaminergic neurons widely distributed throughout the brain‐stem and hypothalamus, and which project to the striatum and limbic system. Parkinsonism is due to degeneration of melanin‐containing dopaminergic neurons of locus coeruleus and substantia nigra, and MPTP provides an investigative probe for studying the causes of Parkinsonism. Neuromelanin should not be regarded as a waste‐product, but as something which can affect the firing properties of neurons with specific functional effect.