bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: An Efficient Synthesis of 1,5‐Benzodiazepines Catalyzed by GaCl3 under Solvent‐Free Conditions.
Authors: Kumar Sanjay , Sandhu Jagir S. 
Published: December 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Highly Stereoselective Synthesis of cis‐Alkenyl Pinacolboronates and Potassium cis‐Alkenyltrifluoroborates via a Hydroboration/Protodeboronation Approach.
Authors: Molander Gary A. , Ellis Noel M. 
Published: December 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Construction of Spiro[4.5]decane via Ring‐Closing Metathesis Reaction: Formal Synthesis of Acorone and Isoacorones.
Authors: Srikrishna A. , Rao M. Srinivasa 
Published: December 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Histone Deacetylase Inhibitors from the Rhizones of Zingiber zerumbet.
Authors: Chung Ill‐Min , Kim Min‐Young , Park Won‐Hwan , Moon Hyung‐In 
Published: December 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Regio‐ and Stereodirected Transformation of 20‐Hydroxyecdysone to 2‐Dehydro‐3‐epi‐20‐hydroxyecdysone under Ozonization in Pyridine.
Authors: Savchenko Rimma G. , Urmanova Yana R. , Shafikov Ruslan V. , Afon'kina Svetlana R. , Khalilov Leonard M. , Odinokov Victor N. 
Published: December 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Fluorinated Analogues of the Neurosteroid GABAA Receptor Antagonist, 17‐PA.
Authors: Deniau Gildas , Sillar Keith T. , O'Hagan David 
Published: December 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Amino‐Zinc‐Ene‐Enolate Cyclization: A Short Access to cis‐3‐Substituted Prolino‐homotryptophane Derivatives.
Authors: Mothes Celine , Lavielle Solange , Karoyan Philippe 
Published: December 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Catalyst‐Free Efficient Synthesis of 3‐Thio‐2‐deoxysugar Derivatives in Water.
Authors: Mandal Pintu Kumar , Maiti Gour Hari , Misra Anup Kumar 
Published: December 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Montmorillonite K‐10 as a Reusable Catalyst for Fischer Type of Glycosylation under Microwave Irradiation.
Authors: Bordoloi Manobjyoti 
Published: December 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Two Unusual Carbohydrate Reactions: Nucleophilic Ring Opening of an Anhydrosugar and Reductive Elimination with Co‐occurring Hydrogenation.
Authors: Krohn Karsten , Ahmed Ishtiaq , Al Sahli Mohammed 
Published: December 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Natural α‐6‐Dehydroxy‐6‐aminoglucoglycerolipids.
Authors: Wu Hai‐Jun , Li Chun‐Xia , Song Gao‐Peng , Li Ying‐Xia 
Published: December 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and in vitro Studies on a Potential Dopamine Prodrug.
Authors: Giannola L. I. , De Caro V. , Giandalia G. , Siragusa M. G. , Lamartina L. 
Published: December 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Archaeal Lipids: Innovative Materials for Biotechnological Applications
Authors: Benvegnu Thierry , Lemiegre Loic , Cammas‐Marion Sandrine 
Published: December 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Dihydropyridines and Atypical MDR: A Novel Perspective of Designing General Reversal Agents for Both Typical and Atypical MDR
Authors: Miri Ramin , Mehdipour Ahmadreza 
Published: December 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: High‐Relaxivity MRI Contrast Agents: Where Coordination Chemistry Meets Medical Imaging
Authors: Werner Eric J. , Datta Ankona , Jocher Christoph J. , Raymond Kenneth N. 
Published: December 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Steroidal Saponins
Authors: Sahu N. P. , Banerjee S. , Mondal N. B. , Mandal D. 
Published: December 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Specific Targeting of Metzincin Family Members with Small‐Molecule Inhibitors: Progress Toward a Multifarious Challenge
Authors: Georgiadis Dimitris , Yiotakis Athanasios 
Published: December 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Peptidomimetic Therapeutic Agents Targeting the Protease Enzyme of the Human Immunodeficiency Virus and Hepatitis C Virus
Authors: Tsantrizos Youla S. 
Published: December 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Design of Small‐Molecule Peptidic and Nonpeptidic Smac Mimetics
Authors: Sun Haiying , Nikolovska‐Coleska Zaneta , Yang Chao‐Yie , Qian Dongguang , Lu Jianfeng , Qiu Su , Bai Longchuan , Peng Yuefeng , Cai Qian , Wang Shaomeng 
Published: December 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Syntheses of the Tedanolides
Authors: Roy Myriam , Kalesse Markus 
Published: December 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Theoretical Studies on Thermolysis Mechanism and Stability of trans‐1,4,5,8‐Tetranitro‐1,4,5,8‐tetraazadecalin Isomers
Authors: QIU Ling , GONG Xue‐Dong , XIAO He‐Ming 
Published: December 2008

AbstractA systematic study on the thermolysis mechanism and stability of a series of energetic cyclic nitramines, trans‐1,4,5,8‐tetranitro‐1,4,5,8‐tetraazadecalin isomers, was performed by density functional theory (DFT) and semiempirical molecular orbital (MO) calculations. Bond dissociation energies (BDE) and activation energies (Ea) of the thermolysis processes were computed at the B3LYP/6‐31G∗︁∗︁ and PM3 levels, respectively. The effect of nitroamino groups on the thermal stability and pyrolysis mechanism of the title compounds was evaluated by the BDE and Ea. The correlations among BDE, Ea, bond overlap populations, energies of the frontier orbitals, and energy gaps were examined in detail. The results indicate that thermal stabilities and decomposition mechanisms of the title compounds derived from the BDE, Ea and static electronic parameters are basically consistent. Homolysis of the N–NO2 bond is the initial step in the thermolysis of the title compounds, the meta‐isomers are more stable than the para‐isomers, and the ortho‐isomers are the most sensitive.
Hydrothermal Synthesis and Structural Characterization of Two Zinc Coordination Polymers of 1,2‐Di(4‐pyridyl)ethylene and Benzenedicarboxylate
Authors: LIU , Dong , LI Hong‐Xi , CHEN Yang , ZHANG Yong , LANG Jian‐Ping 
Published: December 2008

AbstractHydrothermal reactions of Zn(NO3)2·6H2O with 1,2‐di(4‐pyridyl)ethylene (dpe) and 1,4‐benzenedicarboxylate (1,4‐BDC) or 1,3‐benzenedicarboxylate (1,3‐BDC) in water gave rise to two new metal‐organic coordination polymers, [Zn(1,4‐BDC)(dpe)]n (1) and [Zn4O(1,3‐BDC)3(dpe)]n (2). Both compounds were characterized by elemental analysis and IR spectroscopy, and their structures were determined by single crystal X‐ray diffraction. 1 displays a rare 5‐fold interpenetrating 66‐diamondoid framework while 2 possesses an interlocked 3D network formed by inclined interpenetration of 2D (4,4) networks that are constructed by µ4‐oxo tetrazinc Zn4O cores and the bridging dpe and 1,3‐BDC ligands. Thermal and photoluminescent properties of 1 and 2 were also investigated.
Study on the Interaction of Ketoconazole with Human and Bovine Serum Albumins by Fluorescence Spectroscopy
Authors: GUO Qing‐Lian , LI Ran , ZHOU Xin , LIU Yi 
Published: December 2008

AbstractThe binding of ketoconazole to human serum albumin and bovine serum albumin was studied by using fluorescence and ultraviolet spectroscopy. The measurements were performed in 0.1 mol·L−1phosphate buffer solution at pH=7.40±0.1. Decreasing of quenching constant was observed in association with temperature increase. Our findings show that the quenching mechanism of fluorescence of serum albumins by ketoconazole was static quenching because of compound formation. The thermodynamic parametersΔG,ΔH, andΔSat different temperatures were calculated, showing that the electrostatic interactions and hydrophobic interaction are the main forces for the binding of ketoconazole to serum albumins. The distancerbetween the donor (Trp‐214) and acceptor (ketoconazole) was obtained according to fluorescence resonance energy transfer theory.
DFT Study on the Effect of Different Peripheral Chains on Charge Transport Properties of Triphenylene Derivatives
Authors: CHEN Jun‐Rong , CAI Jing , XU Bu‐Yi , LI Quan , ZHAO Ke‐Qing 
Published: December 2008

AbstractBased on the semi‐classical model of the charge transport, theoretical studies on the effect of different peripheral chains including alkynyl on charge transport properties of triphenylene have been carried out using density functional theory (DFT) at the level of B3LYP/6‐31G∗︁∗︁. The results indicate that all the title compounds are advantageous to the charge transport. The introduction of amide RCONH to the discotic ring of triphenylene can raise the positive charge transport rate largely, and introduction of ester in peripheral chains is helpful to the positive charge transport and negative charge transport. The positive charge transport properties of monosubstituted triphenylene are better than those of disubstituted and trisubstituted triphenylenes obviously.
A Rapid and Highly Selective Resonance Scattering Spectral Assay for Trace Carcinoembryonic Antigen
Authors: LI Jian‐Fu , JIANG Zhi‐Liang , DENG An‐Ping 
Published: December 2008

AbstractGold nanoparticles, in size of 10 nm, were used to label monoclonal carcinoembryonic antigen antibody (CEAAb) to obtain an immunonanogold resonance scattering (RS) spectral probe (AuCEAAb) for the measurement of trace carcinoembryonic antigen (CEA). In pH 6.8 Na2HPO4‐NaH2PO4 buffer solution and the presence of polyethylene glycol (PEG)‐6000, the AuCEAAb combined with CEA to form the nanogold‐labeled immunocomplex clusters in average size of 227 nm, which exhibited two scattering peaks at about 320 and 581 nm. The enhanced RS intensity at 581 nm (ΔI581 nm) is proportional to CEA concentration in the range of 1.0–50.0 ng/mL, with a detection limit (DL) of 0.52 ng/mL. The immunonanogold RS assay was utilized to determine CEA in serum samples with high sensitivity, good selectivity and simplicity.
Functional implications of membrane modification with semenogelins for inhibition of sperm motility in humans
Authors: Yoshida Kaoru , Krasznai Zoárd Tibor , Krasznai Zoltán , Yoshiike Miki , Kawano Natsuko , Yoshida Manabu , Morisawa Masaaki , Tóth Zoltán , Bazsáné Zsuzsa Kassai , Márián Teréz , Iwamoto Teruaki 
Published: December 2008

AbstractSemenogelin I and II (Sgs) are the major component of human semen coagulum. The protein is rapidly cleaved after ejaculation by a prostate‐specific antigen, resulting in liquefaction of the semen coagulum and the progressive release of motile spermatozoa. Sgs inhibit human sperm motility; however, there is currently no information on its effect on the sperm membrane. This study investigated the role of Sgs on human sperm motility through regulation of membrane potential and membrane permeability. Fresh semen samples were obtained from normozoospermic volunteers, and studies were conducted using motile cells selected using the swim‐up method. Sgs changed the characteristics of sperm motion from circular to straightforward as evaluated by a computer‐assisted motility analyzer, and all parameters were decreased more than 2.5 mg/mL. The results demonstrate that Sgs treatment immediately hyperpolarized the membrane potential of swim‐up‐selected sperm, changed the membrane structure, and time‐dependently increased membrane permeability, as determined through flow cytometric analysis. The biphasic effects of Sgs were time‐ and dose‐dependent and partially reversible. In addition, a monoclonal antibody against Sgs showed positive binding to cell membrane proteins in fixed cells, observed with confocal fluorescence microscopy. These results demonstrate that Sgs modifies the membrane structure, indirectly inhibiting motility, and provides suggestions for a therapy for male infertility through selection of a functional sperm population using Sgs. Cell Motil. Cytoskeleton 2009. © 2008 Wiley‐Liss, Inc.
Pyridylalanine‐Containing Hydroxamic Acids as Selective HDAC6 Inhibitors
Authors: Schäfer Stefan , Saunders Laura , Schlimme Sonja , Valkov Vassil , Wagner Julia M. , Kratz Felix , Sippl Wolfgang , Verdin Eric , Jung Manfred 
Published: December 2008

AbstractPyridylalanine inhibitors of histone deacetylase (HDAC) have been synthesized that show selectivity for the isoform HDAC6 over HDAC1 in vitro. This selectivity was also identified in cancer cells by analyzing tubulin versus histone acetylation. The compounds show decreased intrinsic cytotoxicity relative to pan‐HDAC inhibitors, but show antiproliferative synergy with the proteasome inhibitor bortezomib.magnified imageWe synthesized hydroxamic acids with a pyridylalanine substructure and identified them as selective inhibitors of human recombinant HDAC6. The in vitro selectivity was up to 25‐fold for HDAC6 over HDAC1 and was confirmed by Western blotting to assess tubulin versus histone acetylation in cancer cells. Docking studies with an HDAC6 homology model suggested that the hydrophobic cap group of the inhibitors interacts with aromatic residues that form a sub‐pocket near the entrance of the substrate binding channel. The HDAC6‐selective compounds have less cytotoxicity toward cancer cells than do pan‐HDAC inhibitors. The synergistic antiproliferative activity we showed with the proteasome inhibitor bortezomib suggests the potential for combination anticancer therapy with less general toxicity.
Phase 2 trial of carboplatin, weekly paclitaxel, and biweekly bevacizumab in patients with unresectable stage IV melanoma
Authors: Perez Domingo G. , Suman Vera J. , Fitch Tom R. , Amatruda Thomas , Morton Roscoe F. , Jilani Shamim Z. , Constantinou Costas L. , Egner James R. , Kottschade Lisa A. , Markovic Svetomir N. 
Published: December 2008

AbstractBACKGROUND: Vascular endothelial growth factor (VEGF) plays an important role in the growth and metastatic progression of melanoma. Exposure of melanoma cells to chemotherapy induces VEGF overproduction, which in turn may allow melanoma cells to evade cell death and become chemotherapy resistant. Therefore, in patients with metastatic melanoma, the combination of chemotherapy with an agent that specifically targets VEGF might be able to control tumor growth and progression more effectively than chemotherapy alone. METHODS: A 2‐stage phase 2 clinical trial was conducted in patients with unresectable stage IV (metastatic) melanoma to assess antitumor activity and the toxicity profile of the combination of carboplatin (area under the curve 6 iv on Day 1 of a 28‐day cycle), paclitaxel (80 mg/m2 iv on Days 1, 8, and 15), and bevacizumab (10 mg/kg iv on Days 1 and 15). Treatment was continued until progression or intolerable toxicity. RESULTS: Fifty‐three patients (62.3% male) were enrolled. Nine (17%) patients achieved partial remission, and another 30 (57%) achieved stable disease for at least 8 weeks. Median progression‐free survival and median overall survival were 6 months and 12 months, respectively. One patient died after 8 treatment cycles from intracranial hemorrhage into undiagnosed brain metastases. The most common severe (grade ≥3) toxicities were neutropenia (53%), thrombocytopenia (11%), hypertension (9%), and anemia (8%). CONCLUSIONS: This combination of carboplatin, paclitaxel, and bevacizumab appears to be moderately well tolerated and clinically beneficial in patients with metastatic melanoma. Further study of this combination is warranted. Cancer 2009. © 2008 American Cancer Society.
Critical and diverse involvement of Akt/mammalian target of rapamycin signaling in human lung carcinomas
Authors: Dobashi Yoh , Suzuki Shioto , Matsubara Hirochika , Kimura Maiko , Endo Shunsuke , Ooi Akishi 
Published: December 2008

AbstractBACKGROUND: Aberrant signaling cascades emanating from epidermal growth factor receptor (EGFR) are involved in the complex network of oncogenic signaling in lung carcinomas. One representative cascade is the phosphatidylinositol 3‐kinase/Akt/mammalian target of rapamycin (mTOR) pathway. METHODS: The authors investigated the involvement of mTOR in the pathobiologic profiles of 150 specimens of lung carcinoma by immunohistochemistry and immunoblotting in correlation with the upstream and downstream proteins Akt and p70S6‐kinase (S6K), respectively. RESULTS: Immunohistochemistry revealed Akt activation in 44% of tumors and mTOR expression in 68.7% of tumors, and the preponderance of activation was observed in adenocarcinoma (AC) (100%). Phosphorylated mTOR (p‐mTOR) was observed in 53.3% of tumors and had the highest frequency in AC (89.7%). In AC, the frequency of p‐mTOR staining was higher in the well differentiated subtype, in particular, in the acinar structure. However, little correlation was observed between the activation of mTOR and Akt, except in the 5 AC specimens that harbored an EGFR gene mutation, which exhibited constitutive activation of both Akt and mTOR. Conversely, in squamous cell carcinomas, mTOR activation was associated with a significantly higher frequency of lymph node metastasis. CONCLUSIONS: The results of this study suggested the dual functions of mTOR. First, mTOR may function not only in the proliferation of tumor cells as an effector molecule downstream of EGFR but also possibly in the morphogenesis of AC. Second, the activation of mTOR may play a key role in metastasis in squamous cell carcinoma. Overall, the current results demonstrated the potential for the application of rapamycin, an mTOR inhibitor, as an additional novel component of chemotherapy for a defined subset of patients with lung carcinoma. Cancer 2009. © 2008 American Cancer Society.
Palladium(II) Phosphotungstate Derivatives: Synthesis and Characterization of the [Pdx{WO(H2O)}3–x{A,α‐PW9O34}2](6+2x)– Anions
Authors: Villanneau Richard , Renaudineau Séverine , Herson Patrick , Boubekeur Kamal , Thouvenot René , Proust Anna 
Published: December 2008

AbstractA series of PdII derivatives of the [P2W21O71(H2O)3]6– heteropolytungstate with the general formula [Pdx{WO(H2O)}3–x{A,α‐PW9O34}2](6+2x)– (x = 1–3) is described. These compounds are obtained by the reaction between [PdII(NO3)2]·H2O and the corresponding vacant polyoxometalates in water. They are characterized by IR and multinuclear NMR (31P and 183W) spectroscopy. Compound K10[Pd2{WO(H2O)}{A,α‐PW9O34}2]·30H2O was characterized by XRD: it crystallized in the orthorhombic space group Pcmn with parameters a = 18.119(3) Å, b = 19.729(3) Å, c = 24.856(5) Å, V = 8886(3) Å3.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)