bluuebunny/crossref_metadata_2025_split huggingface dataset:
Occupational biopsychosocial factors associated with neck pain intensity, neck-disability, and sick leave: A cross-sectional study of construction labourers in an African population
Authors: Igwesi-Chidobe Chinonso N. , Effiong Excellence , Umunnah Joseph O. , Ozumba Benjamin C. 
Published: April 2024

Introduction
The burden and impact of neck pain is high in African countries including Nigeria. This study investigated the occupational biomechanical and occupational psychosocial factors associated with neck pain intensity, neck disability and sick leave amongst construction labourers in an urban Nigerian population.

Methods
This cross-sectional study measured clinical neck pain outcomes, occupational biomechanical factors, and occupational psychosocial factors. Descriptive, and univariate/multivariate inferential statistical analyses were conducted.

Results
Significant independent factors associated with neck pain intensity were order and pace of tasks being dependent on others (β = 0.35; p<0.0001); inability to take breaks in addition to scheduled breaks (β = 0.25; p<0.0001); inability to work because of unexpected events (β = 0.21; p<0.0001); inability to control the order and pace of tasks (β = 0.20; p<0.0001); and weight of load (β = 0.17; p<0.0001); accounting for 53% of the variance in neck pain intensity. Significant independent factors associated with neck disability were weight of load (β = 0.30; p<0.0001); duration of load carriage (β = 0.16; p = 0.01); working under time pressure/deadlines (β = 0.16; p = 0.02); and accounting for 20% of the variance in neck disability. Significant independent factor associated with sick leave was duration of load carriage (β = 0.15; p = 0.04), in a non-significant regression model explaining -4% of the variance in sick leave. Addition of pain intensity significantly explained more variance in neck disability (31.0%) but less variance in sick leave (-5%), which was not statistically significant (F (10, 190) = 0.902, p = 0.533).

Conclusions
Occupational biomechanical factors may be more important than occupational psychosocial factors in explaining neck disability and sick leave. In contrast, occupational psychosocial factors may be more important than occupational biomechanical factors in explaining neck pain intensity in this population in Nigeria.
Clinical characteristics and prognosis of patients with COVID-19 on mechanical ventilation undergoing continuous renal replacement therapy
Authors: Choi Dae-Eun , Kim Duk Ki , Park Sunghoon , Lee Su Hwan , Park Onyu , Kim Taehwa , Yeo Hye Ju , Jang Jin Ho , Cho Woo Hyun , Lee Song I. ,   On behalf of Korean Intensive Care Study Group
Published: April 2024

Background
The coronavirus disease (COVID-19) pandemic has significantly strained global healthcare, particularly in the management of patients requiring mechanical ventilation (MV) and continuous renal replacement therapy (CRRT). This study investigated the characteristics and prognoses of these patients.

Methods
This multicenter retrospective cohort study gathered data from patients with COVID-19 across 26 medical centers. Logistic analysis was used to identify the factors associated with CRRT implementation.

Results
Of the 640 patients with COVID-19 who required MV, 123 (19.2%) underwent CRRT. Compared to the non-CRRT group, the CRRT group was older and exhibited higher sequential organ failure assessment scores. The incidence of hypertension, diabetes, cardiovascular disease, chronic neurological disease, and chronic kidney disease was also higher in the CRRT group. Moreover, the CRRT group had higher intensive care unit (ICU) (75.6% vs. 26.9%, p < 0.001) and in-hospital (79.7% vs. 29.6%, p < 0.001) mortality rates. CRRT implementation was identified as an independent risk factor for both ICU mortality (hazard ratio [HR]:1.833, 95% confidence interval [CI]:1.342–2.505, p < 0.001) and in-hospital mortality (HR: 2.228, 95% CI: 1.648–3.014, p < 0.001). Refractory respiratory failure (n = 99, 19.1%) was the most common cause of death in the non-CRRT death group, and shock with multi-organ failure (n = 50, 40.7%) was the most common cause of death in the CRRT death group. Shock with multi-organ failure and cardiac death were significantly more common in the CRRT death group, compared to non-CRRT death group.

Conclusion
This study indicates that CRRT is associated with higher ICU and in-hospital mortality rates in patients with COVID-19 who require MV. Notably, the primary cause of death in the CRRT group was shock with multi-organ failure, emphasizing the severe clinical course for these patients, while refractory respiratory failure was most common in non-CRRT patients.
The longitudinal relationship between fear of movement and physical activity after cardiac hospitalization: A cross lagged panel model
Authors: Keessen Paul , Kan Kees Jan , ter Riet Gerben , Visser Bart , Jørstad Harald T. , Latour Corine H. M. , van Duijvenbode Ingrid C. D. , Scholte op Reimer Wilma J. M. 
Published: April 2024

Background
Little is known about the association between fear of movement (kinesiophobia) and objectively measured physical activity (PA), the first 12 weeks after cardiac hospitalization.

Purpose
To assess the longitudinal association between kinesiophobia and objectively measured PA and to assess the factor structure of kinesiophobia.

Methods
We performed a longitudinal observational study. PA was continuously measured from hospital discharge to 12 weeks using the Personal Activity Monitor. The PAM measures time spent per day in PA-intensity categories: light, moderate and heavy. Kinesiophobia was assessed with the Tampa Scale for Kinesiophobia (TSK) at four time points (hospital discharge, 3, 6 and 12 weeks). The longitudinal association between PA-intensity and kinesiophobia was studied with a random intercept cross lagged panel model (RI-CLPM). A RI-CLPM estimates effects from kinesiophobia on objectively measured PA and vice versa (cross-over effects), and autoregressive effects (e.g. kinesiophobia from one occasion to the next).

Results
In total, 116 patients (83.6% male) with a median age of 65.5 were included in this study. On no occasion did we find an effect of kinesiophobia on PA and vice versa. Model fit for the original model was poor (X2: = 44.646 P<0.001). Best model fit was found for a model were kinesiophobia was modelled as a stable between factor (latent variable) and PA as autoregressive component (dynamic process) (X2 = 27.541 P<0.12).

Conclusion
Kinesiophobia and objectively measured PA are not associated in the first 12 weeks after hospital discharge. This study shows that kinesiophobia remained relatively stable, 12 weeks after hospital discharge, despite fluctuations in light to moderate PA-intensity.
Quantifying intra-tumoral genetic heterogeneity of glioblastoma toward precision medicine using MRI and a data-inclusive machine learning algorithm
Authors: Wang Lujia , Wang Hairong , D’Angelo Fulvio , Curtin Lee , Sereduk Christopher P. , Leon Gustavo De , Singleton Kyle W. , Urcuyo Javier , Hawkins-Daarud Andrea , Jackson Pamela R. , Krishna Chandan , Zimmerman Richard S. , Patra Devi P. , Bendok Bernard R. , Smith Kris A. , Nakaji Peter , Donev Kliment , Baxter Leslie C. , Mrugała Maciej M. , Ceccarelli Michele , Iavarone Antonio , Swanson Kristin R. , Tran Nhan L. , Hu Leland S. , Li Jing 
Published: April 2024

Background and objective
Glioblastoma (GBM) is one of the most aggressive and lethal human cancers. Intra-tumoral genetic heterogeneity poses a significant challenge for treatment. Biopsy is invasive, which motivates the development of non-invasive, MRI-based machine learning (ML) models to quantify intra-tumoral genetic heterogeneity for each patient. This capability holds great promise for enabling better therapeutic selection to improve patient outcome.

Methods
We proposed a novel Weakly Supervised Ordinal Support Vector Machine (WSO-SVM) to predict regional genetic alteration status within each GBM tumor using MRI. WSO-SVM was applied to a unique dataset of 318 image-localized biopsies with spatially matched multiparametric MRI from 74 GBM patients. The model was trained to predict the regional genetic alteration of three GBM driver genes (EGFR, PDGFRA and PTEN) based on features extracted from the corresponding region of five MRI contrast images. For comparison, a variety of existing ML algorithms were also applied. Classification accuracy of each gene were compared between the different algorithms. The SHapley Additive exPlanations (SHAP) method was further applied to compute contribution scores of different contrast images. Finally, the trained WSO-SVM was used to generate prediction maps within the tumoral area of each patient to help visualize the intra-tumoral genetic heterogeneity.

Results
WSO-SVM achieved 0.80 accuracy, 0.79 sensitivity, and 0.81 specificity for classifying EGFR; 0.71 accuracy, 0.70 sensitivity, and 0.72 specificity for classifying PDGFRA; 0.80 accuracy, 0.78 sensitivity, and 0.83 specificity for classifying PTEN; these results significantly outperformed the existing ML algorithms. Using SHAP, we found that the relative contributions of the five contrast images differ between genes, which are consistent with findings in the literature. The prediction maps revealed extensive intra-tumoral region-to-region heterogeneity within each individual tumor in terms of the alteration status of the three genes.

Conclusions
This study demonstrated the feasibility of using MRI and WSO-SVM to enable non-invasive prediction of intra-tumoral regional genetic alteration for each GBM patient, which can inform future adaptive therapies for individualized oncology.
Not all Medicaid for pregnancy care is delivered equally
Authors: Swartz Jonas J. , Kaufman Menolly , Rodriguez Maria I. 
Published: April 2024

Objectives
Pregnant beneficiaries in the two primary Medicaid eligibility categories, traditional Medicaid and pregnancy Medicaid, have differing access to care especially in the preconception and postpartum periods. Pregnancy Medicaid has higher income limits for eligibility than traditional Medicaid but only provides coverage during and for a limited time period after pregnancy. Our objective was to determine the association between type of Medicaid (traditional Medicaid and pregnancy Medicaid) on receipt of outpatient care during the perinatal period.

Methods
This retrospective cohort study compared outpatient visits using linked birth certificate and Medicaid claims from all Medicaid births in Oregon and South Carolina from 2014 through 2019. Pregnancy Medicaid ended 60 days postpartum during the study. Our primary outcome was average number of outpatient visits per 100 beneficiaries each month during three perinatal time points: preconceputally (three months prior to conception), prenatally (9 months prior to birthdate) and postpartum (from birth to 12 months).

Results
Among 105,808 Medicaid-covered births in Oregon and 141,385 births in South Carolina, pregnancy Medicaid was the most prevelant categorical eligibility. Traditional Medicaid recipients had a higher average number of preconception, prenatal and postpartum visits as compared to those in pregnancy Medicaid.

Discussion
In South Carolina, those using traditional Medicaid had 450% more preconception visits and 70% more postpartum visits compared with pregnancy Medicaid. In Oregon, those using traditional Medicaid had 200% more preconception visits and 29% more postpartum visits than individuals using pregnancy Medicaid. Lack of coverage in both the preconception and postpartum period deprive women of adequate opportunities to access health care or contraception. Changes to pregnancy Medicaid, including extended postpartum coverage through the American Rescue Plan Act of 2021, may facilitate better continuity of care.
Carrying SNP rs17506395 (T > G) in TP63 gene and CCR5Δ32 mutation associated with the occurrence of breast cancer in Burkina Faso
Authors: Traoré Lassina , Savadogo Mousso , Zouré Abdou Azaque , Kiendrebeogo Touwendpoulimdé Isabelle , Soudre Fabienne Marie B. T. B. , Dabre Soayebo , Traore Aida Djé Djénéba , Adico Marc Donald Wilfried , Lare Tilate , Ouedraogo Teega-Wendé Clarisse , Ouedraogo Rogomenoma Alice , Ouattara Abdoul Karim , Yelemkoure Edwige T. , Sawadogo Alexis Yobi , Zongo Nayi , Bambara Hierrhum Aboubacar , Nadembega Christelle W. , Djigma Florencia W. , Simpore Jacques 
Published: April 2024

Abstract
Genetic alterations in the TP63 (GenBank: NC_000003.12, ID: 8626) and CCR5 (receptor 5 chemokine co-receptor) (GenBank: NC_000003.12, ID: 1234) genes may increase the risk of developing breast cancer. The aim of this study was to investigate the probable involvement of polymorphisms rs17506395 in the TP63 (tumour protein 63) gene and the CCR5Δ32 mutation in the occurrence of breast cancer in Burkina Faso. This case–control study included 72 patients and 72 controls. Genotyping of SNP rs17506395 (TP63) was performed by polymerase chain reaction–restriction fragment length polymorphism, and genotyping of the CCR5Δ32 mutation was performed by allele-specific oligonucleotide polymerase chain reaction. For SNP rs17506395 (TP63), the genotypic frequencies of wild-type homozygotes (TT) and heterozygotes (TG) were, respectively, 27.72 and 72.22% in cases and 36.11 and 63.89% in controls. No mutated homozygotes (GG) were observed. For the CCR5Δ32 mutation, the genotypic frequencies of wild-type homozygotes (WT/WT) and heterozygotes (WT/Δ32) were 87.5 and 13.5%, respectively, in the cases and 89.29 and 10.71%, respectively, in the controls. No mutated homozygotes (Δ32/Δ32) were observed. None of the polymorphisms rs17506395 of the TP63 gene (OR = 1.47, 95% CI = 0.69–3.17, P = 0.284) and the CCR5Δ32 mutation (OR = 1.32, 95% CI = 0.46–3.77; P = 0.79) were associated with the occurrence of breast cancer in this study.
pH-based colorimetric detection of monofunctional aldehydes in liquid and gas phases
Authors: dela Cruz Ma. Carmela P. , Organo Voltaire G. 
Published: April 2024

Abstract
An ammonium chloride–Congo red (NH4Cl-CR) solution is presented as a potential sensing solution for aldehydes. Monofunctional aldehydes such as formaldehyde, acetaldehyde, benzaldehyde, and isobutyraldehyde caused changes in the pH of the sensing solution, producing a color transition from red-orange to violet to blue. This distinguished them from the other compounds, thereby acting as a qualitative test for the functional group. The NH4Cl-CR solution was also employed in making filter paper-based and silica gel-based sensors for formaldehyde and acetaldehyde vapors. These sensors responded positively towards the aldehyde gases through a color transition from pink to blue. The NH4Cl-CR mixture provides a simple and easy-to-handle reagent for the detection of both liquid and gaseous aldehydes which has potential applications in environmental monitoring.
Investigating the effect of resveratrol on apoptosis and regulation of gene expression of Caco-2 cells: Unravelling potential implications for colorectal cancer treatment
Authors: Al-Zharani Mohammed , Alkahtane Abdullah A. , AL-Johani Norah S. , Almutairi Bader , Alkeraishan Nora , Alarifi Saud , Alrajeh Sahirah M. , Yaseen Khadijah N. , Aljarba Nada H. , Nasr Fahd A. , Alkahtani Saad 
Published: April 2024

Abstract
Colorectal cancer is known for its substantial impact on global morbidity and mortality, with higher prevalence in developed regions. This study delves into the potential treatment advantages of resveratrol (RSV) in addressing colorectal cancer. Apoptosis and gene expression associated with apoptotic factors were explored using Caco-2 cells, a pertinent model for colorectal adenocarcinoma. The effect of RSV on Caco-2 cell viability was investigated using MTT assay and neutral red uptake assay. The level of generated ROS was high in cells exposed to RSV. Likewise, the enzyme superoxide dismutase, responsible for converting ROS into hydrogen peroxide, was concurrently elevated. The effect of RSV on DNA damage was examined through the TUNEL assay. The gene expression analyses for pro-apoptotic elements were studied using qRT-PCR. Furthermore, the impact of RSV on the migration of Caco-2 cells was conducted through a wound-healing assay. Our results reveal RSV’s cytotoxicity on Caco-2 cells, showing dose-dependent inhibition of viability, indicating its promise as a treatment agent. The induction of cell death by apoptosis is substantiated by DNA damage. Notably, the upregulated expression of caspase-3, Bax, and p53 genes suggests RSV’s potential to modulate key apoptosis-related elements. In addition, RSV displayed an inhibitory effect on cellular migration, a significant (p < 0.05 and p < 0.01) in cancer metastasis. These findings underscore RSV’s potential to be a multifaceted therapeutic agent targeting apoptosis and metastatic processes in colorectal cancer.
It’s the political economy after all: Implications of the case of Israel’s media system transition on the theory of media systems
Authors: Schwartz Moshe , Nossek Hillel 
Published: April 2024

Abstract
This study examines the theory of media systems and the models offered by Hallin and Mancini (2004) by focusing on critical junctures in which changes occur. Based on critical political economy and historical institutionalism, we analyzed the Israeli media system transition in the 1980s and early 1990s, seeking to understand the nature of this change and its theoretical implications. Our findings show a combination of government, market, and public forces in a unique situation where political, economic, and social circumstances change. Accordingly, we conclude that a distinction between politics and economy, as the media system theory and, specifically, the liberal model suggests, is invalid under neoliberalism. We argue that research attention should be paid to critical junctions, and that a closer analysis of government and market interrelations can enrich theories of media systems.
Open Forum in the Dedicated Issue of East European Holocaust Studies on Oral History and the Holocaust
Authors: Dolhanov Petro 
Published: April 2024

Abstract
Oral history constitutes one of the pivotal source categories through which we investigate the Holocaust. The more diverse the source base, the more accurately we can reconstruct the events that transpired. Initially, the study of Holocaust history heavily relied on German documents – essentially, viewing the events through the lens of sources produced by the perpetrators. These sources presented the perspective of the Holocaust’s orchestrators and executors.
The travel of the ‘tongue’ through time and space: a case study of translanguaging in the Macanese food
Authors: Han Lili , Wen Zhisheng (Edward) , Wu Hui 
Published: April 2024

AbstractThe Proto-Indo-European root of the word ‘language’ isdnghū, which means ‘tongue’. Though the concept of ‘translanguaging’ has received enormous research enthusiasm in recent years in both theoretical conceptualization and pedagogical applications, most research has focused on its prefix ‘trans-ʼ (i.e., the boundary-breaking ideology) and its suffix ‘-ing’ (i.e., the on-going process), while its stem ‘-language-’, that is, the ‘tongue’ itself has received less attention. In the current paper, we aim to explore how translanguaging is enacted in the Macanese food (e.g., Fat Tea, orChá Gordoin Portuguese) through absorbing and mixing multiple flavors or tongues, including Portuguese, Malaysian, Indian, Japanese, Cantonese and some African cuisines. In particular, we highlight their diversifying fusion tastes by tracing the Portuguese maritime expansion itinerary routes alongside their multilingual naming practices (Bacalhau,Minchi,African Chicken) in tandem with the transcending memories (from the past to the present). Overall, it is argued that through the analytical lens of the translanguaging perspective, the tongues between the tastes of the food and the languages spoken allow us to peer into the critical values, identities and relationships of the multilingual Macanese group in Macao.
马来西亚华语中的趋向补语
Authors: 齐 锦玉 
Published: April 2024

摘 要
本文基于口语和书面语语料库, 对马来西亚华语中的趋向补语进行考察, 并与普通话对比。 归纳出其三方面的特殊用法, 分别是动趋式带宾语的语序, 特殊结构 “V (O) 来/去O处所” 和 “V到来/去O”, 且这些用法在书面语和口语中呈现出一定的语体差异。 究其原因, 马来西亚华语中趋向补语的特殊用法主要来自马来西亚华人三大 “源方言”, 尤其是粤方言的影响。
Obligation to Mutual Assistance Under Article 42(7) TEU: The Conundrum of Intentional Ambiguity
Authors: Mickonytė Aistė 
Published: April 2024

Abstract
The Russian invasion of Ukraine has had many ramifications beyond the immediate fallout of this egregious act of aggression. The blatancy of such unlawfulness at the EU’s periphery has drawn attention to a somewhat understudied provision, which, however, holds significant relevance given Ukraine’s recently awarded status as an EU candidate: The mutual assistance clause under Art 42(7) TEU. This clause will be examined by exploring its meaning and place in the European security architecture, on its own and in complementarity with Art 5 of the North Atlantic Treaty. It will be argued that both provisions of legally prescribed solidarity bear a curious and uncomfortable semblance to Schrödinger’s cat, capable of appearing as strongly worded, hard-law obligations and as undetermined intentions simultaneously. In particular, both clauses entail intentional normative ambiguity in regard to the forms of assistance to be rendered. Reflecting on how Art 42(7) TEU fits into the EU constitutional framework, it is shown that the mutual assistance clause can be read as capable of holding space for flexible and creative approaches to the legal obligations of the Member States, while as yet falling short of representing an autonomous, EU-based architecture of defence and security.
Privacy and the City: How Data Shapes City Identities
Authors: Petkova Bilyana 
Published: April 2024

Abstract
This article bridges comparative constitutional law with research inspired by city leadership and the opportunities that technology brings to the urban environment. It looks first to some of the causes of rapid urbanization and finds them in the pitfalls of antidiscrimination law in federations and quasi-federations such as the United States and the European Union. Short of achieving antidiscrimination based on nationality, the EU has experimented with data privacy as an identity clause that could bring social cohesion the same way purportedly freedom of speech has done in the US. In the City however, diversity replaces antidiscrimination, making cities attractive to migrants across various walks of life. The consequence for federalism is the obvious decline of top-down or vertical, state-based federalism and the rise of legal urbanism whereby cities establish loose networks of cooperation between themselves. These types of arrangements are not yet a threat to the State or the EU but might become such if cities are increasingly isolated from the political process (e.g., at the EU level) and lack legal means to assert themselves in court. City diversity and openness to different cultures in turn invites a connection to new technologies since unlike antidiscrimination that is usually strictly examined on a case-by-case level, diversity can be more readily computed. Finally, the article focuses on NYC and London initiatives to suggest a futuristic vision of city networks that instead of using social credit score like in China, deploy data trusts to populate their urban environments, shape city identities and exchange ideas for urban development..