bluuebunny/crossref_metadata_2025_split huggingface dataset:
Caspase-11/GSDMD contributes to the progression of hyperuricemic nephropathy by promoting NETs formation
Authors: Wu Fan , Chen Caiming , Lin Guo , Wu Chengkun , Xie Jingzhi , Lin Kongwen , Dai Xingchen , Chen Zhengyue , Ye Keng , Yuan Ying , Chen Zhimin , Ma Huabin , Lin Zishan , Xu Yanfang 
Published: March 2024

AbstractHyperuricemia is an independent risk factor for chronic kidney disease (CKD) and promotes renal fibrosis, but the underlying mechanism remains largely unknown. Unresolved inflammation is strongly associated with renal fibrosis and is a well-known significant contributor to the progression of CKD, including hyperuricemia nephropathy. In the current study, we elucidated the impact of Caspase-11/Gasdermin D (GSDMD)-dependent neutrophil extracellular traps (NETs) on progressive hyperuricemic nephropathy. We found that the Caspase-11/GSDMD signaling were markedly activated in the kidneys of hyperuricemic nephropathy. Deletion of Gsdmd or Caspase-11 protects against the progression of hyperuricemic nephropathy by reducing kidney inflammation, proinflammatory and profibrogenic factors expression, NETs generation, α-smooth muscle actin expression, and fibrosis. Furthermore, specific deletion of Gsdmd or Caspase-11 in hematopoietic cells showed a protective effect on renal fibrosis in hyperuricemic nephropathy. Additionally, in vitro studies unveiled the capability of uric acid in inducing Caspase-11/GSDMD-dependent NETs formation, consequently enhancing α-smooth muscle actin production in macrophages. In summary, this study demonstrated the contributory role of Caspase-11/GSDMD in the progression of hyperuricemic nephropathy by promoting NETs formation, which may shed new light on the therapeutic approach to treating and reversing hyperuricemic nephropathy.
Knotted toroidal sets, attractors and incompressible surfaces
Authors: Barge Héctor , Sánchez-Gabites J. J. 
Published: March 2024

AbstractIn this paper we give a complete characterization of those knotted toroidal sets that can be realized as attractors for discrete or continuous dynamical systems globally defined in $${\mathbb {R}}^3$$

R

3

. We also see that the techniques used to solve this problem can be used to give sufficient conditions to ensure that a wide class of subcompacta of $${\mathbb {R}}^3$$

R

3

that are attractors for homeomorphisms must also be attractors for flows. In addition we study certain attractor-repeller decompositions of $${\mathbb {S}}^3$$

S

3

which arise naturally when considering toroidal sets.
Decreased circulating CTRP3 levels in acute and chronic cardiovascular patients
Authors: Schmid Andreas , Pankuweit Sabine , Vlacil Ann-Kathrin , Koch Sören , Berge Benedikt , Gajawada Praveen , Richter Manfred , Troidl Kerstin , Schieffer Bernhard , Schäffler Andreas , Grote Karsten 
Published: March 2024

Abstract
C1q/TNF-related protein 3 (CTRP3) represents an adipokine with various metabolic and immune-regulatory functions. While circulating CTRP3 has been proposed as a potential biomarker for cardiovascular disease (CVD), current data on CTRP3 regarding coronary artery disease (CAD) remains partially contradictory. This study aimed to investigate CTRP3 levels in chronic and acute settings such as chronic coronary syndrome (CCS) and acute coronary syndrome (ACS). A total of 206 patients were classified into three groups: CCS (n = 64), ACS having a first acute event (ACS-1, n = 75), and ACS having a recurrent acute event (ACS-2, n = 67). The control group consisted of 49 healthy individuals. ELISA measurement in peripheral blood revealed decreased CTRP3 levels in all patient groups (p < 0.001) without significant differences between the groups. This effect was exclusively observed in male patients. Females generally exhibited significantly higher CTRP3 plasma levels than males. ROC curve analysis in male patients revealed a valuable predictive potency of plasma CTRP3 in order to identify CAD patients, with a proposed cut-off value of 51.25 ng/mL. The sensitivity and specificity of prediction by CTRP3 were congruent for the subgroups of CCS, ACS-1, and ACS-2 patients. Regulation of circulating CTRP3 levels in murine models of cardiovascular pathophysiology was found to be partly opposite to the clinical findings, with male mice exhibiting higher circulating CTRP3 levels than females. We conclude that circulating CTRP3 levels are decreased in both male CCS and ACS patients. Therefore, CTRP3 might be useful as a biomarker for CAD but not for distinguishing an acute from a chronic setting.

Key messages

CTRP3 levels were found to be decreased in both male CCS and ACS patients compared to healthy controls. Plasma CTRP3 has a valuable predictive potency in order to identify CAD patients among men and is therefore proposed as a biomarker for CAD but not for distinguishing between acute and chronic settings.

Regulation of circulating CTRP3 levels in murine models of cardiovascular pathophysiology was found to be partly opposite to the clinical findings in men.
The Irreducibility of the Monodromy Representation Associated with the Dotsenko–Fateev Equation
Authors: Mimachi Katsuhisa 
Published: March 2024

AbstractWe study the monodromy representation on the solution space of the Fuchsian differential equation of order 3 derived by Dotsenko and Fateev. In particular, we give a condition for the representation being irreducible, construct the subsystems in reducible cases, and obtain the monodromy-invariant Hermitian form on the solution space.
Mutational analysis in Corynebacterium stationis MFS transporters for improving nucleotide bioproduction
Authors: Kinose Keita , Shinoda Keiko , Konishi Tomoyuki , Kawasaki Hisashi 
Published: March 2024

Abstract
Product secretion from an engineered cell can be advantageous for microbial cell factories. Extensive work on nucleotide manufacturing, one of the most successful microbial fermentation processes, has enabled Corynebacterium stationis to transport nucleotides outside the cell by random mutagenesis; however, the underlying mechanism has not been elucidated, hindering its applications in transporter engineering. Herein, we report the nucleotide-exporting major facilitator superfamily (MFS) transporter from the C. stationis genome and its hyperactive mutation at the G64 residue. Structural estimation and molecular dynamics simulations suggested that the activity of this transporter improved via two mechanisms: (1) enhancing interactions between transmembrane helices through the conserved “RxxQG” motif along with substrate binding and (2) trapping substrate-interacting residue for easier release from the cavity. Our results provide novel insights into how MFS transporters change their conformation from inward- to outward-facing states upon substrate binding to facilitate efflux and can contribute to the development of rational design approaches for efflux improvements in microbial cell factories.

Keypoints
• An MFS transporter from C. stationis genome and its mutation at residue G64 were assessed
• It enhanced the transporter activity by strengthening transmembrane helix interactions and trapped substrate-interacting residues
• Our results contribute to rational design approach development for efflux improvement

Graphical Abstract
A Different Approach for Protruding Earlobe Correction—Modified Fish-tail Technique
Authors: Sert Batuhan , Oral Meltem Ayhan , Turan Ozgur , Uyar Ilker 
Published: March 2024

Abstract
Background
Protruding ears are the most common auricular abnormalities seen in children (1). Protruding ears are a condition that has social and psychological consequences due to its physical appearance and one of the main causes of peer bullying at young ages (2). While various surgical methods exist to address prominent ears, the options for correcting the lobule are relatively scarce. In this study, we are aimed to present the modified fish-tail technique that we have developed and to compare it with other techniques in the literature.

Methods
The patients were selected from the cases that underwent otoplasty for prominent ear correction in our clinic between 2020 and 2022. A total of 21 cases that required protruded lobule correction during otoplasty were included in our study. Keloid and hypertrophic scar formation, wound dehiscence, hematoma, infection and recurrence in the lobule were evaluated. The patients were followed up for at least 1 year for early and late complications.

Results
Each patient in the study underwent bilateral prominent ear correction, including bilateral modified fish-tail technique. All cases were followed for at least 12 months. There was no wound dehiscence, infection, recurrence in lobule prominence or hematoma during the follow-up period. No hypertrophic scar or keloid was observed in any case.

Conclusions
Our method stands out for its ability to achieve both adjustable vertical height and effective lobule correction with a reduced need for skin excision. We recommend the modified fish-tail technique as an alternative technique for prominent lobule surgery.

Level of Evidence IV
This journal requires that authors assign a level of evidence to each article. For a full description of these evidence-based medicine ratings, please refer to the Table of contents or the online Instructions to Authors www.springer.com/00266.
Robot-assisted laparoscopic nephrectomy: early outcome measures with the implementation of multimodal analgesia and intrathecal morphine via the acute pain service
Authors: Meineke Minhthy N. , Losli Matthew V. , Sztain Jacklynn F. , Swisher Matthew W. , Abramson Wendy B. , Martin Erin I. , Furnish Timothy J. , Salmasi Amirali , Derweesh Ithaar H. , Gabriel Rodney A. , Said Engy T. 
Published: March 2024

Abstract
Purpose
The objective of this study was to perform a retrospective cohort analysis, in which we measured the association of an acute pain service (APS)-driven multimodal analgesia protocol that included preoperative intrathecal morphine (ITM) compared to historic controls (i.e., surgeon-driven analgesia protocol without ITM) with postoperative opioid use.

Methods
This was a retrospective cohort study in which the primary objective was to determine whether there was a decrease in median 24-h opioid consumption (intravenous morphine equivalents [MEQ]) among robotic nephrectomy patients whose pain was managed by the surgical team prior to the APS, versus pain managed by APS. Secondary outcomes included opioid consumption during the 24–48 h and 48–72 h period and hospital length of stay. To create matched cohorts, we performed 1:1 (APS:non-APS) propensity score matching. Due to the cohorts occurring at the different time periods, we performed a segmented regression analysis of an interrupted time series.

Results
There were 76 patients in the propensity-matched cohorts, in which 38 (50.0%) were in the APS cohort. The median difference in 24-h opioid consumption in the pre-APS versus APS cohort was 23.0 mg [95% CI 15.0, 31.0] (p < 0.0001), in favor of APS. There were no differences in the secondary outcomes. On segmented regression, there was a statistically significant drop in 24-h opioid consumption in the APS cohort versus pre-APS cohort (p = 0.005).

Conclusions
The implementation of an APS-driven multimodal analgesia protocol with ITM demonstrated a beneficial association with postoperative 24-h opioid consumption following robot-assisted nephrectomy.
Total knee arthroplasty survivorship and outcomes in young patients: a review of the literature and 40-year update to a longitudinal study
Authors: Bergstein Victoria E. , Weinblatt Aaron I. , Taylor Walter L. , Long William J. 
Published: March 2024

Abstract
Introduction
Growing numbers of younger patients are electing to undergo total knee arthroplasty (TKA) for end-stage osteoarthritis. The purpose of this study was to compare established literature regarding TKA outcomes in patients under age 55, to data from an ongoing longitudinal young patient cohort curated by our study group. Further, we aimed to provide a novel update on survivorship at 40 years post-TKA from our longitudinal cohort.

Methods
A literature search was conducted using the electronic databases PubMed, Embase, and Cochrane Library, using terms related to TKA, patients under age 55, and osteoarthritis. Demographic and outcome data were extracted from all studies that met the inclusion criteria. Data were divided into the “longitudinal study (LS) group,” and the “literature review (LR) group” based on the patient population of the study from which it came.

Results
After screening, 10 studies met the inclusion criteria; 6 studies comprised the LR group, and 4 studies comprised the LS group. 2613 TKAs were performed among the LR group, and 114 TKAs were longitudinally followed in the LS group. The mean patient ages of the LR and LS groups were 46.1 and 51, respectively. Mean follow-up was 10.1 years for the LR group. Mean postoperative range of motion was 113.6° and 114.5° for the LR and LS groups, respectively. All-cause survivorship reported at 10 years or less ranged from 90.6% to 99.0%. The LS cohort studies reported survivorship ranges of 70.1–70.6% and 52.1–65.3% at 30 and 40 years, respectively.

Conclusions
Young TKA patients demonstrated improved functionality at each follow-up time point assessed. Survivorship decreased with increasing lengths of follow-up, ultimately ranging from 52.1–65.3% at 40 years post-TKA. The paucity of literature on long-term TKA outcomes in this patient population reinforces the necessity of further research on this topic.
A nasal airflow oscillation device targeting nasal congestion: a preliminary report
Authors: Bartley Jim , Hankin Robin 
Published: March 2024

Abstract
Purpose
Upper respiratory tract complaints are common in the general population. A safe, non-pharmacologic treatment would be an attractive option for many patients either as an alternative to existing therapies, or as a complementary therapy. This study assessed the acceptability, safety and possible efficacy of a nasal airflow oscillation device in a group of people suffering chronic nasal congestion.

Methods
Subjects with a known history of nasal congestion, but without fixed anatomical obstruction, participated in a prospective clinical study. Efficacy was assessed using peak nasal inspiratory flow (NPIF) and a 10-point visual analogue scale (VAS) administered before and after the oscillation device had been worn for twenty minutes.

Results
Twenty-one subjects (mean age 37 years; 43% female) were enrolled in the study. After treatment with the small nasal airflow oscillation device for twenty minutes, average NPIF increased significantly from 84.8 L/minute to 99.0 L/minute (p < 0.05). There was a corresponding significant reduction in the VAS score for nasal congestion (p < 0.05). Similar significant improvements were also seen for the immediate sensation of nasal drainage, sinonasal pressure and overall sinonasal symptoms (p < 0.05). There was no change in the sense of smell (p = 0.37). Subjects rated ease of use highly; average = 9.1 (Range 7–10).

Conclusion
Treatment of nasal congestion with the nasal airflow oscillation device was found to result in significant improvement in NPIF after twenty minutes of use. Initial patient-reported outcomes improved significantly, and the treatment was safe and highly acceptable.

Trial registration
Public clinical trial registration: Universal Trial Number (U1111-1259-0704). Australian New Zealand clinical trials registration: ACTRN12623001307695.
Effectiveness and tolerability of brivaracetam in patients with epilepsy stratified by comorbidities and etiology in the real world: 12-month subgroup data from the international EXPERIENCE pooled analysis
Authors: Szaflarski Jerzy P. , Besson Hervé , D’Souza Wendyl , Faught Edward , Klein Pavel , Reuber Markus , Rosenow Felix , Salas-Puig Javier , Soto Insuga Victor , Steinhoff Bernhard J. , Strzelczyk Adam , Bourikas Dimitrios , Daniels Tony , Floricel Florin , Friesen David , Laloyaux Cédric , Villanueva Vicente 
Published: March 2024

Abstract
Objective
To assess the effectiveness and tolerability of brivaracetam (BRV) in adults with epilepsy by specific comorbidities and epilepsy etiologies.

Methods
EXPERIENCE/EPD332 was a pooled analysis of individual patient records from several non-interventional studies of patients with epilepsy initiating BRV in clinical practice. Outcomes included ≥ 50% reduction from baseline in seizure frequency, seizure freedom (no seizures within prior 3 months), continuous seizure freedom (no seizures since baseline), BRV discontinuation, and treatment-emergent adverse events (TEAEs) at 3, 6, and 12 months. Analyses were performed for all adult patients (≥ 16 years of age) and stratified by comorbidity and by etiology at baseline (patients with cognitive/learning disability [CLD], psychiatric comorbidity, post-stroke epilepsy, brain tumor−related epilepsy [BTRE], and traumatic brain injury−related epilepsy [TBIE]).

Results
At 12 months, ≥ 50% seizure reduction was achieved in 35.6% (n = 264), 38.7% (n = 310), 41.7% (n = 24), 34.1% (n = 41), and 50.0% (n = 28) of patients with CLD, psychiatric comorbidity, post-stroke epilepsy, BTRE, and TBIE, respectively; and continuous seizure freedom was achieved in 5.7% (n = 318), 13.7% (n = 424), 29.4% (n = 34), 11.4% (n = 44), and 13.8% (n = 29), respectively. During the study follow-up, in patients with CLD, psychiatric comorbidity, post-stroke epilepsy, BTRE, and TBIE, 37.1% (n = 403), 30.7% (n = 605), 33.3% (n = 51), 39.7% (n = 68), and 27.1% (n = 49) of patients discontinued BRV, respectively; and TEAEs since prior visit at 12 months were reported in 11.3% (n = 283), 10.0% (n = 410), 16.7% (n = 36), 12.5% (n = 48), and 3.0% (n = 33), respectively.

Conclusions
BRV as prescribed in the real world is effective and well tolerated among patients with CLD, psychiatric comorbidity, post-stroke epilepsy, BTRE, and TBIE.
Deriving and validating a protocol to determine the need for prophylactic peritoneal dialysis in neonates after cardiopulmonary bypass surgery
Authors: Webb Tennille N. , Borasino Santiago , Hock Kristal M. , Aban Inmaculada , Ingram Daryl , Short Kara , Dabal Robert , Askenazi David 
Published: March 2024

Abstract
Background
Prophylactic peritoneal dialysis (PD) in neonates undergoing cardiopulmonary bypass (CPB) is safe and improves outcomes. We sought to (1) derive the pre-operative characteristics of neonates who are most likely to benefit from PD after CPB and (2) validate a new prophylactic PD protocol based on our retrospective analysis.

Methods
First, we retrospectively evaluated neonates requiring cardiac surgery with CPB from October 2012 to June 2016. We categorized neonates as those who “needed PD” and those who “did not need PD” based on prior experience with neonates requiring kidney support therapy. Pre-operative serum creatinine ≥ 0.8 mg/dL, pre-operative weight ≤ 2.5 kg, or having an open chest post-operatively were independently associated with “needed PD.” Next, beginning in March 2019, we implemented a new prophylactic PD protocol in which only those who met at least one of the three criteria derived in the retrospective analysis had a PD catheter placed in the OR.

Results
In Era 2, after the implementation of a new prophylactic PD protocol, 100% of neonates in the “needed PD” group had a PD catheter placed in the OR, which was more than in the prior era (Era 1 = 86.6%) (p = 0.05). Only 26.1% in the “did not need PD” group had a PD catheter placed in the OR which was less than in the prior era (Era 1 = 50.6%) (p < 0.01).

Conclusions
We successfully developed and implemented an evidence-based prophylactic PD protocol that has improved our ability to provide prophylactic PD in neonates after CPB.

Graphical Abstract
An extended intuitionistic fuzzy ABAC method for evaluating innovative project ideas
Authors: Cubukcu Ahmet , Ervural Bilal , Ayaz Halil Ibrahim 
Published: March 2024

AbstractThe innovation process typically follows a predefined sequence of phases: idea generation, screening, evaluation/selection, development, and launch/diffusion. This process exhibits a dynamic and cyclic structure. At each stage, potential ideas may undergo elimination or redefinition based on considerations such as their problem–solution fit or product–market fit. Consequently, the idea evaluation phase can be conducted continuously, involving varying numbers of potential ideas. To address the challenges associated with this process, a systematic approach for selecting the best new project ideas is essential. This study introduces the IF-ABAC method, which extends the alternative-by-alternative comparison-based (ABAC) method to the intuitionistic fuzzy (IF) environment. The proposed approach represents the first combination of fuzzy sets and ABAC within a group decision-making environment. The IF-ABAC method is employed during the evaluation phase, with the best–worst method determining the criteria weights. The study describes how the IF-ABAC approach adeptly manages changes in the set of alternatives after the decision process, addressing the dynamics inherent in decision-making environments. The study further includes an analysis of innovative business ideas in a real case study from Turkey, demonstrating the feasibility and efficiency of the proposed approach. A comprehensive sensitivity analysis is conducted to illustrate the stability and utility of the method. Finally, the results are compared with three other IF-based multi-criteria decision-making methods from the literature. The study concludes by asserting that the proposed IF-ABAC method provides a comprehensive and practical approach to select innovation project ideas in an environment of uncertainty and complexity.
High remnant cholesterol as a risk factor for developing chronic kidney disease in patients with prediabetes and type 2 diabetes: a cross-sectional study of a US population
Authors: Zhu Wenting , Liu Qiushi , Liu Fang , Jiao Chenfeng , Zhang Lihua , Xie Honglang 
Published: March 2024

Abstract
Aims
To examine any potential links between remnant cholesterol (RC) and comorbid chronic kidney disease (CKD) in individuals with prediabetes and type 2 diabetes mellitus (T2DM).

Methods
We used data from 2709 American people aged > 20 years from the National Health and Nutrition Examination Survey (NHANES) during 2011–2018. Subjects were categorized according to whether they had comorbid CKD. Logistic regression models and smoothed curve fitting methods were employed to assess the association of RC with comorbid CKD in patients with prediabetes and T2DM.

Results
The 2709 participants included 1473 patients with T2DM and 1236 with prediabetes [impaired glucose tolerance (IGT) and impaired fasting glucose (IFG)], of whom 744 (27.46%) had comorbid CKD. In multivariate-adjusted analysis, both RC and triglycerides (TG) were significantly associated with an increased risk of comorbid CKD, and a 1 mmol/L elevation of RC increased the risk by 38.1% [OR (95% CI) 1.636 (1.242, 2.156)], which was higher than the risk associated with a 1 mmol/L increase in TG [1.255 (1.106, 1.424)]. Additionally, those in the highest quartile of RC had a 43.6% higher risk of concomitant renal damage than those in the lowest quartile. RC was linearly and positively associated with the incidence of comorbid CKD in this population.

Conclusions
RC is an independent risk factor for comorbid CKD in patients with prediabetes and T2DM. This finding provides a novel insight into the management and early detection of renal disease in patients with impaired glucose metabolism.