bluuebunny/crossref_metadata_2025_split huggingface dataset:
The visceral manifestations of scleroderma
Authors: Sackner Marvin A. 
Published: February 2007

AbstractUntil the latter part of the nineteenth century, scleroderma was considered solely a cutaneous disease. The recognition that proliferation of connective tissue in the viscera was analogous to the skin lesions prompted the name, “progressive systemic sclerosis.” Recent evidence indicates that Raynauds phenomenon, which is frequently associated with scleroderma, is also expressed in the viscera as vasconstriction, particularly in renal and pulmonary arterioles.
An experimental model of calcareous subdeltoid bursitis induced by calciphylaxis
Authors: Selye Hans , Gentile Giovanni , Veilleux René 
Published: February 2007

AbstractA calcareous subdeltoid bursitis can be regularly produced in the rat through calciphylactic challenge by Thorotrast after sensitization with dihydrotachysterol (DHT). This form of calciphylaxis is described merely as an experimental model of the disease without implying that a calciphylactic mechanism is necessarily responsible for structurally comparable lesions in man.
Trace metal composition of synovial fluid from patients with rheumatoid arthritis
Authors: Niedermeier William , Creitz Ellis E. , Holley Howard L. 
Published: February 2007

AbstractSynovial fluid and blood serum from patients with rheumatoid arthritis and from subjects free of symptoms of connective tissue disease were analyzed by emission spectrography. Synovial fluid of patients with rheumatoid arthritis contained increased concentrations of copper, iron and aluminum. Blood serum from these patients contained increased concentrations of copper and rubidium and decreased concentrations of iron, aluminum and chromium.
Hydroxychloroquine sulfate (“Plaquenil”) in treatment of rheumatoid arthritis
Authors: Hamilton E. B. D. , Scott J. T. 
Published: February 2007

AbstractA controlled therapeutic trial in 41 patients comparing hydroxychloroquine (Plaquenil) and a placebo tablet showed a small but statistically significant difference in favor of hydroxychloroquine with regard to the number of analgesic tablets which the patients found it necessary to take in addition to the drug. Less significant differences, but still in favor of hydroxychloroquine, were found with various other methods of assessment. No serious toxic effects were encountered.
The genetics of degenerative joint disease in mice
Authors: Sokoloff Leon , Crittenden Lyman B. , Yamamoto Richard S. , Jay George E. 
Published: February 2007

AbstractOsteoarthritis of the knees in mice is a genetically governed disease in which multiple genes are involved. They have an overall recessive behavior without major sex linkage. Genetic dissociation between the joint disease, obesity and plasma lipids is demonstrated.
Studies on ochronosis. II. Studies on benzoquinoneacetic acid, a probable intermediate in the connective tissue pigmentation of alcaptonuria
Authors: Zannoni Vincent G. , Malawista Stephen E. , La Du Bert N. 
Published: February 2007

AbstractBenzoquinoneacetic acid, the quinone of homogentisic acid, given intraperitoneally to guinea pigs is distributed mainly into skin and cartilage, as found previously with homogentisic acid. In contrast to homogentisic acid, benzoquinoneacetic acid reacts chemically with proteins and homogenates of skin and cartilage in vitro to give products which may be similar to those formed during the development of ochronotic pigmentation of the connective tissues in alcaptonuria. The physical and chemical events leading to ochronosis are discussed.
The occurrence of rheumatoid factor and other abnormalities in families of patients with agammaglobulinemia
Authors: Fudenberg Hugh , German James L. , Kunkel Henry G. 
Published: February 2007

AbstractThe incidence of rheumatoid agglutinating activity (RAA) in parents and siblings of patients with acquired agammsglobulinemia was found to be considerably higher than the incidence of RAA in the normal population. Elevated γ‐globulin levels were also occasionally present, as well as alterations in the β2A and β2M proteins in such relatives. Laboratory findings suggestive of lupus erythematosus were observed in two instances. The high incidence of serum γ‐globulin abnormalities in relatives of patients with idiopathic “acquired” agammaglobulinemia suggests that this is a genetically determined disorder.
Synovial fluid lipids in normal individuals and patients with rheumatoid arthritis
Authors: Bole Giles G. , Peltier Dorothy F. 
Published: February 2007

AbstractNormal human synovial fluid contains trace amounts of phospholipids and cholesterol. Phospholipid composition is similar to that in serum. Rheumatoid synovial fluid contains increased amounts of phospholipid, cholesterol, and neutral lipids. In most cases the concentration is 40 to 60 per cent of that found in simultaneously collected serum specimens. A direct relationship appears to exist between total synovial fluid protein and lipid concentration. No relationship could be established between lipid content in rheumatoid synovial fluid, and total cell content, hyaluronic acid, severity or duration of synovitis in the involved joint.
Anterior capsulectomy in the treatment of rheumatoid arthritis of the knee joint
Authors: Mori Masuta , Ogawa Ryokei 
Published: February 2007

AbstractOver a 7‐year period, capsulectomy was performed on 50 patients with rheumatoid arthritis and on 8 with miscellaneous disorders. A modified method of anterior synovectomy is described. Satisfactory functonal improvement resulted in a significant number of rheumatoid patients.
An historical approach to the nomenclature of rheumatoid arthritis
Authors: Parish Lawrence C. 
Published: February 2007

AbstractThe history of the nomenclature of rheumatoid arthritis has been traced from antiquity to the present discussion of “rheumatoid disease.” Although Guillaume de Baillou recognized rheumatism as being arthritis in 1611, Augustin Jacob Landré Beauvais was the first to describe clearly rheumatoid arthritis, calling it primary asthenic gout in 1800. Sir Alfred Baring Garrod coined the term rheumatoid arthritis in 1858. The British Ministry of Health adopted this term in 1922, and the American Rheumatism Association replaced atrophic arthritis with rheumatoid arthritis in 1941.
Fatal atlanto‐axial luxation in rheumatoid arthritis
Authors: Martel William , Abell Murray R. 
Published: February 2007

AbstractFatal atlanto‐axial dislocation occurred in two patients with rheumatoid arthritis and in both there were severe degenerative changes in the spinal ligaments and skeletal muscle in this area. Attention is called to the frequency of spontaneous cervical dislocations in rheumatoid patients and the advisability of obtaining routine radiographic examination of the cervical spine in patients with advanced disease.
Excretion of a tryptophan metabolite in rheumatoid arthritis
Authors: Spiera Harry 
Published: February 2007

AbstractThe excretion of 3 hydroxy anthranilic acid, a metabolite of trytophan, was studied in a group of patients with rheumatoid arthritis, the other connective tissue diseases, and hospital controls. Ten of 26 patients with rheumatoid arthritis, 3 of 18 with the collagen diseases, and only 1 of 26 hospital controls excreted more than 500 μg. per 24 hours. The quantity excreted did not correlate with any other clinical or laboratory parameter studied. The cause and significance of the increased excretion are unknown.
Studies of the antibody nature of the rheumatoid factor: Reaction of the rheumatoid factor with human specific precipitates and with native human gamma globulin
Authors: Aho Kimmo , Simons Kai 
Published: February 2007

AbstractThe reaction of the RF with diphtheria toxoid‐human antitoxin precipitates was studied. All the RF activity from different rheumatoid sera was absorbed to the specific precipitates. This absorption was not markedly inhibited by even a large excess of added serum gamma globulin. The reaction of the RF with the specific precipitates was found to be reversible. The dissociation reaction was studied quantitatively by using I131‐labeled rheumatoid serum.
Adrenal medullary function in the connective tissue disorders
Authors: Fruehan Alice E. , Frawley Thomas F. 
Published: February 2007

AbstractThe 24 hour urinary excretion of norepinephrine, epinephrine, metanephrine and normetanephrine (MN), and 3‐methoxy‐4‐hydroxy mandelic acid (VMA) was measured in patients with connective tissue disorders and comparisons made with similar measurements performed on normal controls and on patients with acute and chronic illnesses of a non‐rheumatic nature. Patients with rheumatoid arthritis excreted less epinephrine than the normal control group. Patients with a variety of connective tissue diseases other than rheumatoid arthritis or systemic lupus erythematosus had decreased amounts of MN and VMA. Patients with systemic lupus, and those with acute and chronic illnesses of a non‐rheumatic nature, had urinary measurements of catecholamines and catecholamine metabolites comparable to the normal control group.
Histologic study of synovial tissue following oral and intra‐articular administration of phenylbutazone
Authors: Gantner George , Budd John J. , Ramsey Robert H. , Zuckner Jack 
Published: February 2007

AbstractFifty‐one synovial biopsies were obtained from the knee joints of 11 patients with rheumatoid arthritis and eight patients with osteoarthritis. Biopsies were taken before and repeated 3–9 days after treatment with phenylbutazone administered orally or intra‐articularly. Histologic comparisons were made with reference to fibrin and fibrinopurulent material, appearance and thickness of synovial lining cells, edema, stromal hyalinization, inflammatory cell type and distribution, vascular alterations and other changes as noted on hematoxylin and eosin and special stained sections.
Personality patterns of rheumatoid arthritic patients
Authors: Nalven Fredric B. , O'Brien John F. 
Published: February 2007

AbstractThirty‐five female and ten male rheumatoid arthritic outpatients were administered the Minnesota Multiphasic Personality Inventory (MMPI). Their MMPI group profile was found to resemble a classical neurotic pattern with elevations of the MMPI scales could be accounted for by the presence of rheumatoid arthritis‐associated somatic complaints contained within the items of the scales. Further analyses with regard to hostility were also undertaken.
Decreased oxidative deamination of catecholamines associated with clinical scleroderma
Authors: Brunjes Shannon , Arterberry John D. , Shankel Stewart , Johns Varner J. 
Published: February 2007

AbstractUrinary catecholamines and their metabolites were determined in fourteen scleroderma patients and in twenty normals. Scleroderma patients showed significantly decreased output of free epinephrine, total norepinephrine, and vanillylmandelic acid (VMA). There was significant elevation of total normetanephrine (NM), total metanephrine (M) plus total NM, and of the ratio M + NM/VMA. Total was essentially unchanged. This suggested decreased oxidative deamination of both NM and M to form VMA, possibly reflecting inhibition of monoamine oxidase.
Reaction of human and rabbit anti‐gamma‐globulin factors with heavy and light chains of gamma globulin
Authors: Williams Ralph C. 
Published: February 2007

AbstractHuman and rabbit sera containing various anti‐gamma globulin factors showed primary reactivity with H chains of both human and rabbit gamma‐globulin; weak reactions with either human or rabbit L chains were encountered in some human sera from patients with high titers of rheumatoid factors and in 60 per cent of the rabbit antisera tested. Inhibition of agglutination of homologous incomplete antibody coated cells confirmed the major reactivity with human and rabbit H chains, though L chain inhibition was present with selected area.
Significance of antibody to DNA in systemic lupus erythematosus
Authors: Casals Salvador P. , Friou George J. , Myers Lynn L. 
Published: February 2007

AbstractA study was made of serum antibody to DNA and nucleoprotein in 35 patients with SLE, using immunofluorescent spot techniques. Anti DNA was confirmed by complement fixation and observation of the “shaggy” nuclear fluorescent pattern. A striking correlation was observed between presence of anti DNA and the acute phase of SLE. Anti‐nucleoprotein, the most constant finding, showed only a general correlation of titer with phase of disease. Diagnostic and pathogenetic implications are discussed.
Intermittent corticosteroid therapy of juvenile rheumatoid arthritis
Authors: Fisher Delbert A. , Panos Theodore C. , Melby James C. 
Published: February 2007

AbstractFifteen patients 5 to 18 1/2 years of age with definite or classical rheumatoid arthritis were treated for a mean duration of 22 months (12 to 32 months) with intermittent triamcinolone on a 7 day on, 5 day off therapy or a 3 day on, 4 day off therapy regimen. Eleven of the 15 patients showed remission or major improvement in their disease. The only complication of significance was osteoporosis. Only moderate suppression of pituitary‐adrenal function was observed.
Lupus erythematosus associated with sickle cell anemia
Authors: Wilson Francis M. , Clifford George O. , Wolf Paul L. , Borges Wayne H. , Toone Elam , Pirani Conrad L. 
Published: February 2007

AbstractA case of sickle cell anemia complicated by the development of SLE With elements of the nephrotic syndrome is presented. Since the nephrotic syndrome may rarely appear with sickle cell anemia, the coincidence of these two diseases in a patient may easily be over looked. At necropsy there was definite evidence of both diseases.
Alterations in the histopathology of systemic lupus erythematosus with steroid therapy
Authors: Rosenthal Alan S. , Thomson John B. 
Published: February 2007

AbstractA clinical and pathologic study of 25 autopsy cases of systemic lupus erythematosus is presented correlating clinical and histopathologic improvement following steroid therapy. The literature concerning the effects of steroids on the histopathology of SLE is reviewed. Though in this, as well as other studies, the treated patient lived longer (average of 14 months), the previously reported corresponding histologic improvement could not be demonstrated in any of the lesions.
Social psychological researches into brachialgia and periarthritis
Authors: Oesterreicher W. , Van Dam G. 
Published: February 2007

AbstractA comparison with a “healthy” control group has indicated psychological factors and disturbed adaptation probably contributed to the occurrence of periarthritis humeroscapularis with objective complaints. Absenteeism occurred more by periarthritis humeroscapularis; unemployment more by brachialgia. In men with periarthritis humeroscapularis, physical trauma played a role; in men with brachialgia, psychosocial factors and disturbed adaptation were more important.
Gamma globulin metabolism in rabbits immunized with autologous denatured gamma globulin
Authors: Catsoulis Evangelos A. , Rothschild Marcus A. , Oratz Murray , Franklin Edward C. 
Published: February 2007

AbstractAntibodies resembling rheumatoid factor (RF) were produced in rabbits by immunization with alkali denatured autologous gamma globulin (RGG) in Freund's adjuvant. Gamma globulin metabolism was studied with I131 labeled gamma globulin in 5 such rabbits and in 4 control rabbits treated with Freund's adjuvant alone. Albumin metabolism was studied in 4 immunized rabbits and in 4 rabbits treated with adjuvant alone employing rabbit albumin I131 (RSA‐I131). The two groups differed in that only the immunized group of rabbits demonstrated rheumatoid factor like antibodies while the adjuvant treated animals lacked these antibodies. Gamma globulin levels, pool size and degradation increased in equivalent degree in both groups. Consequently the increase in gamma globulin degradation appears to be unrelated to the presence of this antibody and probably reflects the increase in gamma globulin pool size. Albumin degradation was not significantly affected.
Steroid therapy of systemic lupus erythematosus based on immunologic considerations
Authors: Lange Kurt , Ores Richard , Strauss Walter , Wachstein† Max 
Published: February 2007

AbstractPatients with Systemic Lupus Erythematosus were treated continuously with large doses of glucocorticoids until the immunologic abnormalities had returned to normal, irrespective of prior relief from subjective complaints. Thereafter, prolonged intermittent steroid therapy with large doses was used, guided by immunologic data and continued for at least two years. With this therapy immunosuppression was maintained and the disease controlled. Side‐effects were minimal. Loss of renal function markedly improved under this therapy even in advanced cases.
Effect of some anabolic and antianabolic agents on the mineral component of osseous tissue
Authors: Tesárek Bretislav , Prokopová‐Roubalová Drahomíra 
Published: February 2007

AbstractThe antianabolic action of corticosteroids on rat osseous tissue can be intensified by simultaneous fixation of the extremity. By administration of Superanabolon (19‐nor testosteronephenyl‐propionate) a partial improvement can be achieved which is manifested by an increase of the weight and ash content of the bone, as compared with the controls.
The significance of antinuclear factors in rheumatoid arthritis
Authors: Condemi John J. , Barnett Eugene V. , Atwater Edward C. , Jacox Ralph F. , Mongan Edward S. , Vaughan Recipientjohn H. 
Published: February 2007

AbstractSixty‐eight patients with definite or classic rheumatoid arthritis were studied to determine the significance of the presence of antinuclear factors. The patients with positive antinuclear factor determinations were those with more severe disease. These patients almost always had subcutaneous nodules, which were not always associated with a high latex titer for rheumatoid factor. Necrotizing vasculitis occurred in both antinuclear factor positive and negative patients. Our data do not support the notion that a positive antinuclear factor test or a positive L.E. cell test should be used to exclude the diagnosis of rheumatoid arthritis.
Relation of intracytoplasmic inclusions in joint fluid leukocytes to anti‐γG globulins
Authors: Vaughan John H. , Jacox Ralph F. , Noell Phyllis 
Published: February 2007

AbstractAnti γ globulin activities have been demonstrated by fluorescent staining in the inclusions of leukocytes of patients with seropositive rheumatoid arthritis. Other patients lacked such inclusions. The strong relationships in rheumatoid arthritis between staining for γ globulins and the seropositive state, and between presence of inclusions and lowered joint fluid complement activity, have been conformed. The mean levels of γA and γ globulins, but not of γG globulins, were higher in the joint fluids of patients with rheumatoid arthritis than in other patients.
Clinical studies on gonococcal arthritis and reiter's syndrome and measurement of gonococcal and bedsonia antibodies
Authors: Sharp John T. , Lidsky Martin D. , Riley William A. 
Published: February 2007

AbstractClinical and serologic studies on 94 patients suspected of having gonococcal arthritis or Reiter's syndrome are reported. Twenty‐eight patients had arthritis due to a Neisserian organism. Causative organisms were identified as gonococci in 19 instances. The species of the remaining 9 organisms was not identified. Seven patients exhibited the complete Reiter's syndrome. Neither clinical features nor measurement of gonococcal or Bedsonia antibodies were sufficient to establish a diagnosis in those cases that had sterile blood and synovial fluid cultures and lacked the Reiter's triad.
Serum antinuclear antibodies in progressive systemic sclerosis (scleroderma)
Authors: Rothfield Naomi F. , Rodnan Gerald P. 
Published: February 2007

AbstractSera from 47 patients with PSS were studied for the presence of antinuclear antibodies. Antinuclear antibodies were present in 60 per cent of the sera in a titer of 1:16 or greater. In most cases the titer was low, but a titer of 1:256 or greater was present in sera from 6 patients. The pattern of nuclear fluorescence was most commonly that of fine or large speckles. Most sera contained both IgC and IgM antinuclear antibodies. There was no relation between duration of disease or severity of disease and the presence of antinuclear antibodies. Similarly, no correlation could be demonstrated between clinical findings and the immunoglobulin class, titer, or staining pattern of antinuclear antibody. The prevalence of high tilers of antinuclear antibodies was greater in patients with hypergammaglobulinemia than in those with normal levels of gamma globulin. Rheumatoid factor was present in 33 per cent of sera. Patients with high liters of rheumatoid factor tended to have high tilers of antinuclear antibodies. Antinuclear antibodies were found in low titer in 7 per cent of blood relatives less than 60 years of age. The number of sera with antinuclear antibodies was slightly higher in the non‐aged relatives of patients with systemic lupus erythematosus (11 per cent), while the prevalence in relatives of patients with chronic discoid lupus (2 per cent) was similar to that of a group of healthy student nurses. The results reveal that antinuclear antibodies of a speckled pattern are commonly present in sera from patients with FSS and appear to be unrelated to the duration or severity of the disease. The peripheral pattern of nuclear fluorescence produced by sera from acutely ill patients with systemic lupus erythematosus was not observed with any of the sera of patients with PSS. These obs 3 ervations emphasize the fact that the presence of antinuclear antibodies in general is not diagnostic of any one disease, and indicate that the pattern of nuclear fluorescence produced by the antinuclear antibodies may aid in confirmation of clinical diagnosis.
The Clinical Differentiation of Lead Gout from Primary Gout
Authors: Emmerson Bryan T. 
Published: February 2007

AbstractA group of gouty patients with renal disease following lead poisoning in childhood was compared with another group of gouty patients in whom a lead etiology could be excluded. Comparison revealed that the lead gout group contained a higher proportion of women, half of whom were premenopausal. The lead gout group also showed a greater incidence of renal disease in kindred, of hypertension in siblings, and sequelae of acute lead encephalopathy in the form of mental impairment and euphoria. The severity and the number of attacks of acute gouty arthritis, however, was less in the lead gout group. Renal disease was invariable in lead gout and antedated the gouty arthritis. Features occurring more frequently in the primary gout group were regular alcohol consumption, obesity and renal calculi. These findings confirm previously reported features of primary gout and provide pointers to a possible lead etiology in other gouty patients.
Age and weight in osteoarthritis of the hip
Authors: Saville Paul D. , Dickson Jessie 
Published: February 2007

AbstractWe examined 121 men and women suffering from primary and secondary osteoarthritis of the hip with respect to age at orthopedic consultation, body weight, and height. Body weight distribution among patients with primary osteoarthritis of the hip was similar to that of patients with secondary osteoarthritis of the hip and to normal men and women in the United States. There was no correlation between age at orthopedic consultation and body weight. We conclude that body weight is not an important factor in the development of osteoarthritis of the hip. Primary osteoarthritis affects one or the other side or both sides with equal frequency. Individuals with bilateral disease were not older than those with unilateral disease. We conclude that the disease is unilateral or bilateral at its inception rather than progressing from one side to the other with time.