bluuebunny/crossref_metadata_2025_split huggingface dataset:
Guide wire extension may not be essential to pass an over‐the‐wire balloon catheter
Authors: Ahmad Tanvir , Webb John G. , Carere Ronald G. , Dodek Arthur 
Published: March 2007

AbstractThe ability to pass an angioplasty balloon catheter over a regular length free guidewire can be advantageous in certain circumstances. This procedure was performed successfully in 99 consecutive patients without any complications. There was improved tactile sense of the lesion and improved dye delivery without the necessity of resorting to the use of extension wires or magnet exchange device. When performed while observing the required precautions this is a safe procedure.
Percutaneous balloon pericardiotomy: A double‐balloon technique
Authors: Iaffaldano Robert A. , Jones Paul , Lewis Bruce E. , Eleftheriades Elias G. , Johnson Sarah A. , McKiernan Thomas L. 
Published: March 2007

AbstractWe describe a double‐balloon technique for performing a percutaneous balloon pericardiotomy. This technique was employed when the large, single dilation balloon customarily used for this procedure failed to fully inflate across the parietal pericardium. Two smaller balloons were advanced through the same skin tract and simultaneously inflated, thus producing an adequate pericardial window. This double‐balloon technique allowed for the more secure anchoring of the balloons across the pericardium and for the delivery of greater dilation pressures. © 1995 Wiley‐Liss, Inc.
Morphologic characteristics of restenotic lesions following coronary interventions: Balloon angioplasty versus directional atherectomy: Can we speculate about the mechanism of restenosis from morphologic analysis?
Authors: Moreu Jose , Silver Marc T. , Palacios Igor F. , Jang Ik‐Kyung 
Published: March 2007

AbstractIn order to compare the processes of restenosis after balloon angioplasty as compared to that after directional coronary atherectomy, we performed qualitative and quantitative analysis of 72 lesions in 68 patients with recurrent ischemia following a successful initial procedure. For each lesion, we reviewed the pre‐intervention, immediate post‐intervention, and restenosis angiograms. The morphology of the restenotic lesions could not be predicted from pre‐ or post‐intervention angiograms. The restenotic lesions after directional atherectomy, as compared to balloon angioplasty, did not show a statistically significant difference, although there was a trend to more eccentric narrowing. © 1995 Wiley‐Liss, Inc.
Juxtaposed “kissing” stents as a technique to preserve both limbs of a bifurcating renal artery
Authors: Avula Surendra , Dorros Gerald 
Published: March 2007

AbstractPercutaneous revascularization with balloon expandable stent placement and/or balloon angioplasty has been proven to be an effective alternative for renal artery bypass surgery for management of renal artery stenosis. Endovascular stent deployment has been proven to be superior to balloon angioplasty alone, especially for ostial lesions in terms of maintaining long‐term patency. Here we describe a case report for deployment of two Palmaz stents with simultaneous utilization of brachial and femoral routes. Technical aspects for this procedure, especially adaptation of coronary guide wire systems in management of renal artery stenosis were discussed. © 1995 Wiley‐Liss, Inc.
Method of preparing, mounting, and implanting a palmaz‐schatz coronary half‐stent from the stent delivery system
Authors: Koh Tian‐Hai 
Published: March 2007

AbstractFull‐length 15 mm Palmaz‐Schatz coronary stents currently come premounted in a specially designed stent delivery system. A method is described for obtaining a bare half‐stent from this system and mounting it onto a balloon catheter. The technique of half‐stent delivery and implantation is discussed and is illustrated by a case example. © 1995 Wiley‐Liss, Inc.
Percutaneous transvenous mitral commissurotomy using inoue balloon catheter: A left femoral vein approach
Authors: Patel Tejas M. , Dani Sameer I. , Rawal Jayesh R. , Shah Sanjay C. , Patel Thakorebhai K. 
Published: March 2007

AbstractPercutaneous transvenous mitral commissurotomy by the Inoue technique is usually recommended from right femoral vein approach only. We report an unusual patient in whom the left femoral vein approach was used successfully. We believe that the left femoral vein approach can be reserved as a last resort in certain cases. © 1995 Wiley‐Liss, Inc.
Predictors of short term clinical and angiographic outcome after coronary angioplasty for acute myocardial infarction
Authors: Zimarino Marco , Corcos Thierry , Favereau Xavier , Garcia Elias , Tamburino Corrado , Guérin Yves 
Published: March 2007

AbstractCoronary angioplasty is an effective method to achieve myocardial reperfusion in acute myocardial infarction (AMI). We reviewed our experience in 132 patients (pts) who underwent percutaneous transluminal coronary angioplasty (PTCA) of a totally occluded infarct‐related artery (IRA) within 24 h after the onset of symptoms (mean delay 10±7 h), in order to identify the predictors of primary success and of major complications. PTCA was successfully performed in 113 patients (86%). Failure without complications occurred in 12 patients (8.4%); untoward events (death and emergency CABG) occurred in seven patients (5.3%). Pts in the failure group were more likely to have cardiogenic shock (53 vs. 8.8%, P<.0005), longer time to reperfusion (15±6 vs. 9±6 h, P<.0005), lower ejection fraction (EF) (42±16 vs. 54±12%, P<.0005), multivessel disease (74 vs. 43%, P<.03), and a smaller IRA diameter (2.8±0.6 vs. 3.1± 0.6 mm, P<.03). Sex, age, previous bypass surgery, previous thrombolytic treatment, IRA, and infarct location were similar in both groups. Absence of cardiogenic shock (P<.0001), decreasing time to reperfusion (P<.005) and increasing EF (P<.02) were independent predictors of successful PTCA. Presence of cardiogenic shock (P<.0001) and decreasing EF (<.05) were independent predictors of untoward events. Repeat angiography was performed 24 h after the procedure in the success group. Angiographic deterioration (stenosis ⩾ 50% and/or TIMI flow grade ⩽ 1) was present in 18 pts (16%), among whose 5 pts (4.4%) had re‐occlusion of the IRA. Pts with early angiographic deterioration were more likely to have a lower IRA diameter (2.8±0.5 vs. 3.1±0.6 mm, P<.02). Conclusion: Emergency PTCA is an effective method for establishing reperfusion in AMI. Pts with high‐risk baseline characteristics show the highest rate of untoward events, but are the most likely to benefit from aggressive reperfusion therapy. © 1995 Wiley‐Liss, inc.
Late development of dissecting aneurysm following balloon angioplasty of native aortic coarctation
Authors: Aydogan Umrah , Dindar Aygun , Gurgan Lerzan , Cantez Talat 
Published: March 2007

AbstractAcute aortic dissection during balloon angioplasty for coarctation of the aorta or aneurysm formation during follow‐up are well‐known complications of this procedure. Dissecting aneurysm development during long‐term follow‐up after balloon angioplasty of a native coarctation has not been previously reported. We report a case in which a huge dissecting aneurysm developed 3 years after the native coarctation angioplasty procedure. The aneurysm required surgical repair. © 1995 Wiley‐Liss, Inc.
Transcatheter embolization coil closure of patent ductus arteriosus ‐modified delivery for enhanced control during coil positioning
Authors: Kuhn Micheal A. , Latson Larry A. 
Published: March 2007

AbstractThe use of Gianturco coils (Cook, Inc., Bloomington, IN) has been recently described as a method of occluding restrictive patent ductus arteriosus (PDA). Precise control of the coil during positioning or withdrawal is difficult. We designed an inexpensive and readily available system to control the coil during delivery and repositioning. A 5 French Mallincrodt vertebral catheter was heat tapered to allow slight, but definite resistance of a 0.035″ guide wire when it was passed through the catheter. The delivery system has been used to successfully coil occlude restrictive PDAs in seven patients. The system has added no additional costs to the procedure and has provided improved control of the coil position prior to release of the coil. © 1995 Wiley‐Liss, Inc.
Efficacy of angioscopy in determining the effectiveness of intracoronary urokinase and TEC atherectomy thrombus removal from an occluded saphenous vein graft prior to stent implantation
Authors: Kaplan Barry M. , Safian Robert D. , Goldstein James A. , Grines Cindy L. , O'Neill William W. 
Published: March 2007

AbstractPercutaneous revascularization of thrombus containing saphenous vein grafts is associated with a high incidence of acute complications. This case report describes successful revascularization of an occluded vein graft employing angioscopically guided sequential urokinase infusion, TEC atherectomy and stent implantation. © 1995 Wiley‐Liss, Inc.
Coronary angioplasty of branch vessels associated with an extreme angle take‐off
Authors: Gershony Gary , Hussain Hassan , Rowan William 
Published: March 2007

AbstractStenoses in branch vessels which originate at an acute angle to the main vessel represent a technically challenging anatomy for the performance of balloon angioplasty [PTCA]. We report a novel technique utilizing a distally placed perfusion balloon that facilitated guidewire placement and subsequent balloon angioplasty of a branch vessel stenosis. © 1995 Wiley‐Liss, Inc.
Evidence for dynamic coronary vasoconstriction of non‐infarct vessels during acute myocardial infarction
Authors: Kahn Joel K. 
Published: March 2007

AbstractThe role of coronary vasoconstriction in acute myocardial infarction is controversial. Two patients are presented who were studied with angiography during the early hours of acute myocardial infarction and in whom reversible spasm of non‐infarct vessels was observed. A tendency towards coronary vasospasm may be a generalized phenomenon during acute myocardial infarction. © 1995 Wiley‐Liss, Inc.
Mouse thymus dendritic cells: kinetics of development and changes in surface markers during maturation
Authors: Wu Li , Vremec David , Ardavin Carlos , Winkel Ken , Süss Gabriele , Georgiou Harry , Maraskovsky Eugene , Cook Wendy , Shortman Ken 
Published: March 2007

AbstractThe early thymus precursor population of adult mice has the capacity to generate T cells, B cells and dendritic cells (DC). These precursors were injected into the thymus of irradiated recipients in order to follow the kinetics of thymic DC development. The resultant cohort of T‐lineage cells developing in the thymus was accompanied by a parallel cohort of DC, present at 103‐fold lower frequency. The intrathymic lifespan of these DC was as short as that of T‐lineage thymocytes. As the thymic DC matured, some markers characteristic of the original precursor population gradually declined (Ly‐5, c‐kit, Sca‐2) whereas markers characteristic of thymic DC appeared and were maintained (major histocompatibility complex class II, CD11c, NLDC‐145 and CD8α). Some thymic DC expressed the early B‐cell marker BP‐1, and BP‐1 mRNA, throughout their maturation. The surface markers on thymic DC could be divided into two groups. Some markers, including class I and class II MHC, CD8α and BP‐1, appeared to be integral components of the DC surface. In contrast, other markers, including Thy‐1, CD4 and CD8β, had probably been picked up from associated thymocytes.
Precursor B cells of mouse bone marrow express two different complexes with the surrogate light chain on the surface
Authors: Winkler Thomas H. , Rolink Antonius , Melchers Fritz , Karasuyama Hajime 
Published: March 2007

AbstractTwo monoclonal antibodies raised against the complex of μ heavy (H) chain and Vpre‐B/λ5 surrogate light (L) chains recognize surrogate L chain in different conformations on normal pre‐B cells. One, LM34 recognizes free λ5 protein and free λ5/Vpre‐B surrogate L chains and binds to surrogate L chains on the surface of early, pro‐B and pre‐B‐I cells where the surrogate L chain is associated with a gp130/gp35–65 complex of proteins. It also recognizes the surrogate L chain associated with the μH chain on pre‐B‐II cells. The other monoclonal antibody, SL156, does not recognize free surrogate L chain or its components, nor its complex with gp130/gp35–65 on pro‐B and pre‐B‐I cells. However, it does bind to a conformational epitope on the surrogate light chain/μH chain complex on a subpopulation of pre‐B‐II cells and on μH chain‐positive pre‐B cell lines. On mouse precursor B cells prepared ex vivo on ice, expression of the surrogate L chain is very low and almost undetectable. Incubation of the precursor cells for 1 h at 37 °C up‐regulates the surface expression of surrogate L chain associated with gp130/gp35–65 (early complex) as well as the μH chain/surrogate L chain complex. These results reconcile some of the apparently discrepant results on surface expression of the surrogate L chain obtained with human and mouse bone marrow pre‐B cells, and show that a surrogate L chain/μH chain‐containing pre‐B cell receptor can be expressed also on the surface of mouse pre‐B‐II cells.
Distribution of HLA class II molecules in epidermal Langerhans cells in situ
Authors: Mommaas A. Mieke , Mulder Aat A. , Out Coby J. , Girolomoni Giampiero , Koerten Henk K. , Vermeer Bert J. , Koning Frits 
Published: March 2007

AbstractWe performed immunoelectron microscopic studies to investigate the expression of HLA class II molecules in Langerhans cells (LC). In the epidermis, LC expressed class II molecules on the plasma membrane of the dendrites, resulting in a class II positive reticulo‐epithelial network, but not on the surface of the cell body. In contrast, isolated LC as well as activated LC in situ displayed an even and strong expression of class II molecules on their entire cell surface. Therefore, isolation and/or activation results in redistribution and up‐regulation of class II molecules on the cell surface. In addition, double‐labeling experiments were carried out with monoclonal antibodies to class II antigens and to LAMP‐1, CD63 and α‐glucosidase, specific markers for organelles of the endosomal/lysosomal system. The results show expression of class II molecules on intracellular, electron‐dense vesicular structures, and co‐localization of class II molecules and the markers for late endosomes and early lysosomes in human LC in situ. Expression of these markers was not found on Birbeck granules, an LC‐specific organelle.
Carbohydrate‐dependent, HLA class II‐restricted, human T cell response to the bee venom allergen phospholipase A2 in allergic patients
Authors: Dudler Thomas , Altmann Friedrich , Carballido José M. , Blaser Kurt 
Published: March 2007

AbstractThe T cell‐independent antibody response to polysaccharide antigen (Ag) is believed to result from their inability to bind major histocompatibility complex (MHC) restriction elements. However, recent studies using glycosylated analogues of known immunogenic peptides revealed that glycopeptides can interact with MHC molecules and are able to elicit specific T cell responses in experimental animals. This raises questions about the possible role which carbohydrates can play in T cell responses following natural exposure to glycoprotein antigens. Analyzing the fine specificity of the human T cell response against the major bee venom allergen phospholipase A2 (PLA), a 16–20‐kDa protein glycosylated at a single site (Asn13), we have identified several T cell clones which proliferate in response to the glycoprotein but not to its non‐glycosylated variants. Neither the carbohydrate moiety alone nor the combination of carbohydrate and nonglycosylated protein could substitute for the intact glycoprotein. Antibody directed against the carbohydrate moiety inhibited Ag‐induced proliferation of these clones whereas control clones with known peptide specificity were not affected, providing additional evidence for the involvement of carbohydrates in T cell recognition. Moreover, peripheral blood mononuclear cells of two individuals from whom glycosylation‐dependent T cell clones have been isolated showed significantly higher proliferation in response to glycosylated compared to non‐glycosylated Ag, suggesting that glycosylation can contribute in some cases extensively to the immunogenicity of a glycoprotein Ag. Thus, this report shows that glycosylation‐dependent Ag recognition by T cells can also occur following natural exposure to a glycoprotein.
Regulation of an anti‐polysaccharide immune response in BALB/c mice through a tight T and B lymphocyte idiotypic connection
Authors: Rademaekers André , Kölsch Eckehart 
Published: March 2007

AbstractThe isotype expression in the J558 idiotype‐associated humoral immune response against α(1 → 3)‐dextran in BALB/c mice is controlled by idiotype‐specific T cells which silence in situ B lymphocytes primed and committed to an IgG response. This leads to a restriction of the type II thymus‐independent response to the sole production of IgM antibodies. The availability of the T cell receptor (TcR) α and β sequences for such a regulatory T cell clone allows the investigation of the degree of heterogeneity of the TcR usage of these T cells. It is found that all α(1 → 3)‐dextran‐primed BALB/c mice use a very similar, possibly identical TcR. This suggests a tight, possibly genetically programmed, interaction between the J558 idiotype‐bearing dextran‐specific B cells and their idiotype‐specific regulatory T cell counterparts.
The nude mutation results in impaired primary antibody repertoire
Authors: Kaushik Azad , Kelsoe Garnett , Jaton Jean‐Claude 
Published: March 2007

AbstractWe have studied the effect of the nude mutation and/or T lymphocytes on the development of V gene germ‐line repertoire in neonatal athymic (nu/nu) and euthymic (+/nu) littermates. A total of 2.35 × 106 and 1.47 × 106 B lymphocyte clones from nu/nu and +/nu neonates, respectively, were examined for the expression of select VH (J558, J606, S107, 36–60, 7183 and Q52) and Vx (1, 2, 8 and 9) gene families as well as VH (J558, S107) + Vx (1, 9) associations. Data showed that the nude mutation, whether homozygous or heterozygous, significantly affects VH and Vx gene expression as well as VH and Vx pairings and, thus, provide evidence for a defective development of B cell repertoire in both athymic nude (nu/nu) and euthymic (+/nu) mice. In addition, an analysis of 3.34 × 106 B lymphocyte clones from adult C57BL/6 mice showed non‐stochastic association between VHJ558 + Vx1 gene families that suggests restrictions on clonal population in order to maintain homeostasis in the immune system. Studies outlined here, therefore, describe an hitherto unknown defect in the development of B lymphocyte repertoire as a result of the nude mutation which is independent of thymic dysgenesis.
Comparison of lymphokine secretion and mRNA expression in the CD45RA+ and CD45RO+ subsets of human peripheral blood CD4+ and CD8+ lymphocytes
Authors: Conlon Kevin , Osborne Jennifer , Morimoto Chikao , Ortaldo John R. , Young Howard A. 
Published: March 2007

AbstractFlow cytometric analysis of human peripheral blood T lymphocytes demonstrated that the majority of the CD4+ cells were CD29+ or CD45RO+ “mature” cells while the CD8+ cells were primarily CD45RA+ “naive” cells. After an initial separation into CD4+ and CD8+ cells and a secondary separation into CD45 subsets, lymphokine secretion was assessed after phorbol 12‐myristate 13‐acetate and ionomycin or fixed anti‐CD3 stimulation. Within the respective CD45 subsets, CD4+ cells produced more interleukin (IL)‐2, IL‐4, and IL‐6; but the CD8+ cells secreted more interferon‐γ and granulocyte/macrophage‐colony‐stimulating factor. Tumor necrosis factor‐α secretion was similar in the matched CD45 subsets. Northern analysis revealed a parallel pattern of lymphokine mRNA expression in the four lymphocyte subsets. These results suggest that human CD8+ peripheral blood lymphocytes have a significant capacity to secrete lymphokines, and that the low lymphokine production observed in unseparated CD8+ cells reflects the higher percentage of less functional CD45RA+ cells.
Heparin inhibits the antiparasitic and immune modulatory effects of human recombinant interferon‐γ
Authors: Däubener Walter , Nockemann Susanne , Gutsche Marc , Hadding Ulrich 
Published: March 2007

AbstractInterferon‐γ (IFN‐γ) is a potent immune regulatory cytokine and is, in addition, involved in the induction of antiparasitic effector mechanisms in different cell types. The first step of IFN‐γ action is its binding to a specific receptor. Furthermore, it has been shown that IFN‐γ binds with a great affinity to the heparin‐like structure of heparan sulfate, which is localized in basement membranes and on cell surfaces. In this study, we analyze the effect of heparin and heparan sulfate on three different IFN‐γ‐mediated activities inducible in human glioblastoma cells (87HG31 and 86HG39).We find firstly that heparin is able to inhibit IFN‐γ‐mediated induction of major histocompatibility complex (MHC) class II antigen expression on 87HG31 cells, an effect which can be abrogated by protamine. Secondly, we show that heparin inhibits the IFN‐γ‐induced toxoplasmostasis within 86HG39 cells in a dose‐dependent fashion, and thirdly that heparin inhibits the IFN‐γ‐mediated induction of the tryptophan‐degrading enzyme indoleamine 2,3‐dioxygenase. In contrast to IFN‐γ‐induced effects, the activity of other cytokines, such as interleukin (IL)‐1, IL‐2 and IL‐6, is not influenced by heparin. The possible mechanism of heparin‐induced inhibition of IFN‐γ is discussed.
Role of the thymus in the generation of skin‐homing αβ and γδ virgin T cells
Authors: Washington Elizabeth A. , Kimpton Wayne G. , Holder Joanne E. , Cahill Ross N. P. 
Published: March 2007

AbstractCurrent models of lymphocyte traffic suggest that homing specificities of T cells to tissues such as skin are generated outside the thymus as a result of activation of naive T cells by antigen in lymph nodes. Virgin T cells are thought to home to high endothelial venules in lymph nodes, but are thought to be unable to home to extra‐lymphoid tissues such as skin. We used the technique of in situ labeling of the thymus with fluorescein isothiocyanate to examine the homing specificities of authentically naive T cells in vivo, immediately after their export from the thymus. We report that homing specificities for skin as well as lymph node are imprinted on T cells inside the thymus, independent of antigen. We also show that both αβ and γδ emigrant T cells exhibit homing patterns to skin and lymph nodes which are identical to those of mature T cells. Our findings demonstrate a key role for the thymus in the induction of skin‐homing specificities on T cells indicating that skin‐homing specificities of T cells are not generated solely outside the thymus as a result of the activation of virgin T cells by antigen. The migration of thymic emigrants to extra‐lymphoid tissues within a few hours of leaving the thymus may have implications for mechanisms of peripheral self‐tolerance. This pathway provides an opportunity for direct virgin T cell interactions with self components only expressed in the periphery at a time when emigrants may be more susceptible to tolerance induction than mature circulating T cells.