bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of the COVID‐19‐pandemic and perception of self‐efficacy on the mental health of out‐of‐hospital emergency healthcare professionals by modality of care
Authors: Cárdaba‐García Rosa María , Soto‐Cámara Raúl , García‐Santa‐Basilia Noemi , Matellán‐Hernández María Paz , Onrubia‐Baticón Henar , Martínez‐Caballero Carmen María , Thuissard‐Vasallo Israel John , Navalpotro‐Pascual Susana ,   Membership of the IMPSYCOVID‐19 Study Group
Published: March 2024

AbstractObjectiveTo analyse the influence of the COVID‐19 pandemic and the perception of self‐efficacy on the health professionals of the Spanish out‐of‐hospital emergency services.DesignObservational, cross‐sectional and descriptive with a survey methodology of 1710 participants from Spain (1 February–30 April, 2021).MethodsThe mental health of healthcare workers was assesed in terms of stress, anxiety and depression, as well as their self‐efficacy. Linear and logistic regression models were fitted to predict these variables. A moderation analysis was conducted to determine the effect of self‐efficacy on mental health.ResultsThe means of the sample for stress, anxiety, depression and self‐efficacy were 20.60, 15.74, 13.07 and 70.87, respectively. In the regression models, being a woman was the most significant factor for severe mental health impairment. Female gender was also a relevant factor for self‐efficacy. Self‐efficacy had a direct effect on the mental health for working in patient care.ConclusionsHealthcare workers showed moderate stress, severe anxiety, mild depression and good self‐efficacy. Direct patient care was associated with more stress and severe anxiety. Age, female gender, job changes and job adjustment were associated with levels of stress, anxiety and depression. Self‐efficacy is a determining factor of mental health in the direct care modality.ImplicationsThe mental health of healthcare workers has been of great importance in the aftermath of the pandemic, but out‐of‐hospital emergency workers have been neglected in research. The levels of stress, anxiety and depression during the pandemic justify the creation of prevention and early diagnosis programmes, as they are essential in a health disaster. Surprisingly, their high level of perceived self‐efficacy directly impact on the mental health of patient helthcare workers, so improving it will reduce the psychological risk.Reporting MethodWe have followed the STROBE guidelines. It has been partially funded by the Asistencia Sanitanitaria Interprovincial de Seguros ‐ ASISA Foundation (Spain).Patient or Public Contribution‘No patient or public involvement’.
Network visualization to interpret which healthcare services are central to people living with HIV
Authors: Kim Gwang Suk , Baek Seoyoung , Kim Namhee , Shim Mi‐So , Lee SangA , Lee YoungJin , Park Chang Gi , Kim Layoung 
Published: March 2024

AbstractAimTo employ network analysis to identify the central healthcare service needs of people living with HIV (PLWH) for integrated care.DesignCross‐sectional survey.MethodsA list of healthcare services was identified through literature reviews, expert workshops and validity evaluations by PLWH. A total of 243 PLWH participated at five hospitals and self‐reported their need for healthcare services on a four‐point Likert scale. Centrality of healthcare service needs was analysed using network analysis.ResultsThe mean score for 20 healthcare service needs was 3.53 out of 4. The highest scoring need, “Precaution for interaction between antiretroviral therapy and other drugs,” received a rating of 3.73 but had a centrality of only 0.31. The most central node in the network of healthcare service needs, “Information and coping with opportunistic infections,” had a strength centrality of 1.63 and showed significant relationships with “non‐HIV‐related medical services (e.g., health check‐ups)” and “Regular dental services.” The correlation stability coefficient, which quantifies the stability of centrality, was 0.44 with an acceptable value.ConclusionsThe most central need was information on opportunistic infections that had connections with many nodes in network analysis. By interpreting the relationships between needs, healthcare providers can design interventions with an integrative perspective.Implications for Patient CareNetwork visualization provides dynamic relationships between needs that are unknown from the score scale by presenting them graphically and qualitatively.ImpactUsing network analysis to interpret need assessment offers an integrated nursing perspective. Coping with opportunistic infection is central to connecting the chain of healthcare. This study highlights the multifaceted understanding of patients' needs that nurses gain when they conduct network analysis.Reporting MethodWe adhered to the STROBE checklist.Patient or Public ContributionNo patient or public contribution.
circ_HMGCS1 modulates hepatocellular carcinoma chemoresistance via miR‐338‐5p/IL‐7 pathway
Authors: Zhang Siyu , Ma Jun , Yu Tingdong , Song Zhengrui , Lau Wan Yee , Zha Yong 
Published: March 2024

AbstractHepatocellular cancer is one of the most serious types of cancer in the world, with high incidence and mortality rates. Most HCC patients with long‐term chemotherapy develop chemoresistance, leading to a poor prognosis. However, the underlying mechanism of circRNAs in HCC chemoresistance remains unclear. Our research found that circ_0072391(circ_HMGCS1) expression was significantly upregulated in cisplatin‐resistant HCC cells. The silence of circ_HMGCS1 attenuated the cisplatin resistance in HCC. Results showed that circ_HMGCS1 regulated the expression of miR‐338‐5p via acting as microRNA sponges. Further study confirmed that miR‐338‐5p regulated the expression of IL‐7. IL‐7 could remodel the immune system by improving T‐cell function and antagonising the immunosuppressive network. IL‐7 is an ideal target used to enhance the function of the immune system. circ_HMGCS1 exerts its oncogenic function through the miR‐338‐5p/IL‐7 pathway. Inhibition of circ_HMGCS1/miR‐338‐5p/IL‐7 could effectively attenuate the chemoresistance of HCC. IL‐7 might be a promising immunotherapy target for HCC cancer treatment.
Analysis of the genetic structure of the introduced clearhead icefish (Protosalanx chinensis) populations in northern China
Authors: Zheng Yi , Tang Fujiang , Zheng Xianhu , Na Rongbin , Li Zhe , Lu Wanqiao , Lu Cuiyun 
Published: March 2024

AbstractWhen species are introduced to a new environment, they can quickly adapt to the environment and may differ from the indigenous species. The indigenous population of Protosalanx chinensis has a high level of genetic diversity, but it is unclear on the genetic diversity of the introduced populations in northeast China, which supports the major production of P. chinensis in the world. A total of 556 individuals of P. chinensis were collected during 2016–2021, from Lianhuan Lake (LHL), Xingkai Lake (XK), and Shuifeng Reservoir (SF), and one population was collected from the indigenous Taihu Lake (TH). Overall, 36 haplotypes were detected, and the genetic differences in P. chinensis populations within and between river basins were investigated. The nucleotide diversity (π) of the populations ranged from 0.0005 to 0.0032, and the haplotype diversity (Hd) ranged from 0.455 to 0.890, with the highest genetic diversity in the TH population, followed by the SF population, and lower genetic diversity in the XK and LHL populations. The analysis of the genetic differentiation index (Fst) and the genetic distance between populations showed that there was significant genetic differentiation between the TH population and the other populations. More sampling points have been set up in LHL for further analysis; the Dalong Lake (DL) and the Xiaolong Lake (XL) populations were far from the other populations within the LHL population. In this study, we didn't find a correlation between population size, stability, and genetic diversity, and the ecological measures of management should be decisive to the population dynamics. These results provide a basis for the rational utilization and effective management of P. chinensis.
Pulsed light processing of low sugar, added fiber RTD mango beverage
Authors: Pravallika Kosana , Shaik Lubna , Alzahrani Khalid J. , Misra N. N. , Chakraborty Snehasis 
Published: March 2024

AbstractReady‐to‐drink (RTD) mango beverage enriched with short‐chain fructooligosaccharides (scFOS) was developed to reduce added sugar and incorporate a soluble prebiotic fiber. The impact of pulsed light (PL) technology on microbial inactivation, enzyme activity, and quality attributes in scFOS‐enriched mango RTD beverages was investigated. Effective PL fluence of 0.12–1.2 J/cm2 was employed on mango beverage in order to maximize the retention of nutritional properties along with inactivation of microbial and enzymatic activity. There is complete inactivation of microbial load and enzymatic activity with 72.45, 84.17, 88, 78.79, and 77.63% retention of ascorbic acid, antioxidants, total phenolics, total flavonoids, and total carotenoids in 6% scFOS mango beverage at an effective fluence of 1.2 J/cm2. There is no wide change in TSS, pH, and TA in all the PL treatments. The scFOS increased viscosity, and it also protected bioactives, namely, carotenoids, ascorbic acid, and phenolics, from photoxidation caused by PL. Results showed that scFOS allowed a substantial reduction in added sugar and increased soluble fiber content in the beverage. Sensory score of 3 and 6% scFOS‐enriched beverages were closely comparable with control. The study showcases the potential of scFOS to enhance the nutritional profile of beverages. It also highlights the effectiveness of PL processing in pasteurization fruit beverages, meeting stakeholders' demands for microbial safety, enzymatic stability, and nutrient retention.Practical applicationsThe practical applications of this research hold significant promise for the food and beverage industry. The innovative formulations of ready‐to‐drink (RTD) mango beverages not only reduce added sugar by up to 52% but also increase fiber content from 0.6 to 6%, meeting consumer demands for healthier options. The integration of pulsed light technology effectively targets microbial and enzyme inactivation, complying with Food and Drug Administration standards and offering a viable processing method. The incorporation of short‐chain fructooligosaccharides enhances the protection of bioactive compounds during pulsed light treatment, ensuring higher retention of antioxidants, vitamins, and other valuable components. This advancement contributes to improved nutritional profiles while maintaining sensory appeal. These findings have the potential to revolutionize RTD beverage production, addressing health‐conscious consumer preferences, and enhancing product quality.
National Institute on Aging's 50th anniversary: Advancing aging research and the health and well‐being of older adults
Authors: Kelley Amy , Addie Siobhan , Carrington‐Lawrence Stacy , Ferrucci Luigi , Jones Patricia , Hadley Evan , Haim Todd , Harper Jessica , Kahana Shoshana , Kelley Melinda , Kohanski Ronald , Masliah Eliezer , McConnell Cindy , Morrison Stephanie , Nielsen Lisbeth , Santora Kenneth , Hodes Richard 
Published: March 2024

AbstractThe National Institute on Aging (NIA), part of the National Institutes of Health (NIH), was founded in 1974 to support and conduct research on aging and the health and well‐being of older adults. Fifty years ago, the concept of studying aging generated much skepticism. Early NIA‐funded research findings helped establish the great value of aging research and provided the foundation for significant science advances that have improved our understanding of the aging process, diseases and conditions associated with aging, and the effects of health inequities, as well as the need to promote healthy aging lifestyles. Today, we celebrate the many important contributions to aging research made possible by NIA, as well as opportunities to continue to make meaningful progress. NIA emphasizes that the broad aging research community must continue to increase and expand our collective efforts to recruit and train a diverse next generation of aging researchers.
Response of nitrergic system in the brain of rat conditioned to intracranial self‐stimulation
Authors: Choudhary Amit G. , Awathale Sanjay N. , Dudhabhate Biru B. , Pawar Namrata , Jadhav Gouri , Upadhya Manoj A. , Khedkar Trupti , Gadhikar Yashashree A. , Sakharkar Amul J. , Subhedar Nishikant K. , Kokare Dadasaheb M. 
Published: March 2024

AbstractThe role of nitrergic system in modulating the action of psychostimulants on reward processing is well established. However, the relevant anatomical underpinnings and scope of the involved interactions with mesolimbic dopaminergic system have not been clarified. Using immunohistochemistry, we track the changes in neuronal nitric oxide synthase (nNOS) containing cell groups in the animals conditioned to intracranial self‐stimulation (ICSS) via an electrode implanted in the lateral hypothalamus‐medial forebrain bundle (LH‐MFB) area. An increase in the nNOS immunoreactivity was noticed in the cells and fibers in the ventral tegmental area (VTA) and nucleus accumbens shell (AcbSh), the primary loci of the reward system. In addition, nNOS was up‐regulated in the nucleus accumbens core (AcbC), vertical limb of diagonal band (VDB), locus coeruleus (LC), lateral hypothalamus (LH), superficial gray layer (SuG) of the superior colliculus, and periaqueductal gray (PAG). The brain tissue fragments drawn from these areas showed a change in nNOS mRNA expression, but in opposite direction. Intracerebroventricular (icv) administration of nNOS inhibitor, 7‐nitroindazole (7‐NI) showed decreased lever press activity in a dose‐dependent manner in ICSS task. While an increase in the dopamine (DA) and 3, 4‐dihydroxyphenylacetic acid (DOPAC) efflux was noted in the microdialysates collected from the AcbSh of ICSS rats, pre‐administration of 7‐NI (icv route) attenuated the response. The study identifies nitrergic centers that probably mediate sensory, cognitive, and motor components of the goal‐directed behavior.image
First report of Fusarium redolens causing root rot of Goji berry cv. ‘Ningqi‐7’ in China
Authors: Xu C. Y. , Gao H. H. , Han Q. , Jia C. B. , Swingle B. , Gao M. , Su J. Y. 
Published: March 2024

AbstractGoji berry is an important cash crop of the Ningxia Hui Autonomous Region of China. In the summer of 2019 and 2020, a root rot outbreak appeared in Zhongning County Ningxia Hui Autonomous Region. The correct identification of the causal agent is very important for prevention and cure of this root rot disease. The rotten root samples of symptomatic trees were dug for strain isolation using tissues separation method. The fungi were identified based on both morphological characteristics and molecular signatures. Five healthy 1‐year‐old goji berry cv. ‘Ningqi‐7’ seedlings inoculated with F. redolens QT114 showed root rot symptoms and F. redolens was re‐isolated from the rotted roots of inoculated seedlings. This is the first report of F. redolens causing root rot of Chinese wolfberry (L. barbarum L. cv. ‘Ningqi‐7’).
Research on soil‐borne diseases of ginseng due to root exudates
Authors: Jia Sen , Yang Shiyou 
Published: March 2024

AbstractIn a monocropping pattern for the crop domestication process, the interspecific and intraspecific interaction modes can be changed. In domesticated crops, the intraspecific interactions may have detrimental effects. Moreover, soil‐borne diseases in consecutive monocropped medicinal crops can be a critical challenge that has been difficult to solve. This study has been conducted to evaluate the effect of monoculture and intercropped cultivation on soil‐borne diseases caused by root secretions in American ginseng. The results of the correlation analysis showed that the polyethylenes in the roots had a more negative correlation with the occurrence of soil‐borne diseases than ginsenosides. Therefore, polyethylenes can be considered as an important factor in replanting failure of American ginseng. Furthermore, polyethylenes were able to remain in the soil and have a greater impact on the incidence of soil‐borne diseases than ginsenosides.
Colletotrichum siamense is associated with post‐harvest anthracnose of red onion in the Philippines
Authors: Dimayacyac Deborah Anne , Balendres Mark Angelo 
Published: March 2024

AbstractOnion (Allium cepa L.) is an important crop widely cultivated in the Philippines. In the Philippines, Colletotrichum gloeosporioides sensu lato and C. circinans have been reported to cause anthracnose twister disease and onion smudge, respectively. This study reports C. siamense from anthracnose‐infected onion bulbs. The fungus was identified using morpho‐cultural characterization and multi‐locus analyses of the nuclear ribosomal internal transcribed spacer with 5.8S region (ITS) glyceraldehyde‐3‐phosphate dehydrogenase gene (GAPDH) and beta‐tubulin (TUB2). Koch's postulates were established in pathogenicity assays where the fungus caused diseases in wounded and non‐wounded onion bulbs. This study is the first scientific report of C. siamense as a post‐harvest anthracnose pathogen of onion bulbs in the Philippines.
Molecular detection of ‘Candidatus phytoplasma aurantifolia’ associated with virescence and phyllody of Zinnia peruviana: A new record for India
Authors: Mahadevakumar S. , Sarma P. V. S. R. N. , Danteswari C. , Joy Josna , Chandranayaka S. , Patro T. S. S. K. 
Published: March 2024

AbstractZinnia peruviana (Asteraceae) is an annual flowering plant cultivated in various gardens of Mysore, the south of Karnataka state, India. During 2021, phytoplasma‐like symptoms such as virescence and phyllody were observed on Zinnia in Mysore local gardens. A total of 10 symptomatic and five asymptomatic samples were collected, and the DNA was amplified by PCR using primers specific to 16S RNA and secA genes. The nucleotide sequence analysis showed that the 16S RNA and SecA gene sequences were most similar to those of ‘Ca. P. aurantifolia’, with identities greater than 99%. The phytoplasma sequence from this study shared a common clade with ‘Ca. P. aurantifolia’ when phylogenetic analysis was done. Similarly, the reference sequences for the 16S rRNA and SecA region confirmed the identity of the phytoplasma associated with the leaves of Zinnia. This is the new host record for ‘Ca. P. aurantifolia’ (16SrII‐D) phytoplasma associated with Z. peruviana from India.
First report of Trichothecium roseum causing pink mould on strawberry fruit in Iran
Authors: Maghsoodi Fatemeh , Taheri Parissa , Tarighi Saeed 
Published: March 2024

AbstractStrawberry (Fragaria × ananassa) is one of the most important fruit crops, worldwide. In June 2023, strawberry fruits with pink mould symptoms were collected from a storage facility in Khorasan Razavi province of Iran. Trichothecium roseum was isolated from symptomatic fruit and identified through morphological characteristics. Molecular identification was carried out based on the internal transcribed spacer (ITS) region of ribosomal DNA (rDNA) using ITS1 and ITS4 primers. Pathogenicity was confirmed according to Koch's postulates. Cell wall–degrading enzyme secretion was investigated as a potential factor in fungal pathogenicity. The results of morphological identification, ITS analysis and pathogenicity test indicated that the causal agent was T. roseum. Enzyme activity assays revealed that T. roseum obtained from strawberry with a high level of aggressiveness was able to secrete cellulase and pectinase. To our knowledge, this is the first report of post‐harvest pink mould of strawberry caused by T. roseum in Iran.
A recycling quality improvement project to engage the multidisciplinary team with sustainability efforts
Authors: Gray Phoebe , Gubb Samuel , Butler Jessica , Walton Benjamin 
Published: March 2024

AbstractBackgroundThe provision of healthcare itself contributes to the global health crisis of the climate emergency. As critical care is a carbon hotspot within hospital medicine, healthcare professionals must take collaborative action to mitigate the environmental impact of the sector.AimThe purpose of the project was to engage the critical care multidisciplinary team with sustainability efforts, through involvement in a recycling Quality Improvement Project (QIP). The central QIP aimed to increase the recycling rates of single‐use plastic enteral feed bottles in the intensive care unit (ICU) over a 31‐day period.Study DesignA recycling ‘challenge month’ was launched, and staff opinion was surveyed before and after this intervention.ResultsThe QIP demonstrated an increase in feed bottle recycling by 53.2%, representing a carbon‐saving effect of up to 6.02 kg CO2e for the intervention month. Following the central QIP, all survey respondents felt encouraged to consider their ICU's environmental impact.ConclusionsSimple successful QIPs can act as a springboard to engage the staff body with sustainability initiatives and ignite wider conversation and consideration of the climate emergency in daily practice.Relevance for Clinical PracticeEffective recycling constitutes only one element of responsible environmental stewardship, but authors discuss that it is an effective focus for QIPs. To maximize impact and success within critical care, nursing involvement in leading and participation is essential.