bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systematic HOIP interactome profiling reveals critical roles of linear ubiquitination in tissue homeostasis
Authors: Fu Yesheng , Li Lei , Zhang Xin , Deng Zhikang , Wu Ying , Chen Wenzhe , Liu Yuchen , He Shan , Wang Jian , Xie Yuping , Tu Zhiwei , Lyu Yadi , Wei Yange , Wang Shujie , Cui Chun-Ping , Liu Cui Hua , Zhang Lingqiang 
Published: April 2024

AbstractLinear ubiquitination catalyzed by HOIL-1-interacting protein (HOIP), the key component of the linear ubiquitination assembly complex, plays fundamental roles in tissue homeostasis by executing domain-specific regulatory functions. However, a proteome-wide analysis of the domain-specific interactome of HOIP across tissues is lacking. Here, we present a comprehensive mass spectrometry-based interactome profiling of four HOIP domains in nine mouse tissues. The interaction dataset provides a high-quality HOIP interactome resource with an average of approximately 90 interactors for each bait per tissue. HOIP tissue interactome presents a systematic understanding of linear ubiquitination functions in each tissue and also shows associations of tissue functions to genetic diseases. HOIP domain interactome characterizes a set of previously undefined linear ubiquitinated substrates and elucidates the cross-talk among HOIP domains in physiological and pathological processes. Moreover, we show that linear ubiquitination of Integrin-linked protein kinase (ILK) decreases focal adhesion formation and promotes the detachment of Shigella flexneri-infected cells. Meanwhile, Hoip deficiency decreases the linear ubiquitination of Smad ubiquitination regulatory factor 1 (SMURF1) and enhances its E3 activity, finally causing a reduced bone mass phenotype in mice. Overall, our work expands the knowledge of HOIP-interacting proteins and provides a platform for further discovery of linear ubiquitination functions in tissue homeostasis.
Gadd45g insufficiency drives the pathogenesis of myeloproliferative neoplasms
Authors: Zhang Peiwen , You Na , Ding Yiyi , Zhu Wenqi , Wang Nan , Xie Yueqiao , Huang Wanling , Ren Qian , Qin Tiejun , Fu Rongfeng , Zhang Lei , Xiao Zhijian , Cheng Tao , Ma Xiaotong 
Published: April 2024

AbstractDespite the identification of driver mutations leading to the initiation of myeloproliferative neoplasms (MPNs), the molecular pathogenesis of MPNs remains incompletely understood. Here, we demonstrate that growth arrest and DNA damage inducible gamma (GADD45g) is expressed at significantly lower levels in patients with MPNs, and JAK2V617F mutation and histone deacetylation contribute to its reduced expression. Downregulation of GADD45g plays a tumor-promoting role in human MPN cells. Gadd45g insufficiency in the murine hematopoietic system alone leads to significantly enhanced growth and self-renewal capacity of myeloid-biased hematopoietic stem cells, and the development of phenotypes resembling MPNs. Mechanistically, the pathogenic role of GADD45g insufficiency is mediated through a cascade of activations of RAC2, PAK1 and PI3K-AKT signaling pathways. These data characterize GADD45g deficiency as a novel pathogenic factor in MPNs.
Modified t-butyl in tetradentate platinum (II) complexes enables exceptional lifetime for blue-phosphorescent organic light-emitting diodes
Authors: Jung Young Hun , Lee Gyeong Seok , Muruganantham Subramanian , Kim Hye Rin , Oh Jun Hyeog , Ham Jung Ho , Yadav Sagar B. , Lee Ji Hyun , Chae Mi Young , Kim Yun-Hi , Kwon Jang Hyuk 
Published: April 2024

AbstractIn blue phosphorescent dopants, the tetradentate platinum(II) complex is a promising material showing high efficiency and stability in devices. However, metal-metal-to-ligand charge transfer (MMLCT) formation leads to low photo-luminescence quantum yields (PLQYs), wide spectra, and intermolecular interaction. To suppress MMLCT, PtON-tb-TTB and PtON-tb-DTB are designed using theoretical simulation by modifying t-butyl in PtON-TBBI. Both materials effectively suppress MMLCT and exhibit high PLQYs of 99% and 78% in 5 wt% doped film, respectively. The PtON-tb-TTB and PtON-tb-DTB devices have maximum external quantum efficiencies of 26.3% and 20.9%, respectively. Additionally, the PtON-tb-DTB device has an extended lifetime of 169.3 h with an initial luminescence of 1200 nit, which is 8.5 times greater than the PtON-TBBI device. Extended lifetime because of suppressed MMLCT and smaller displacement between the lowest triplet and triplet metal-centered states compared to other dopants. The study provides an effective approach to designing platinum(II) complexes for long device lifetimes.
Differentiation granules, a dynamic regulator of T. brucei development
Authors: Cayla Mathieu , Spanos Christos , McWilliam Kirsty , Waskett Eliza , Rappsilber Juri , Matthews Keith R. 
Published: April 2024

AbstractAdaptation to a change of environment is an essential process for survival, in particular for parasitic organisms exposed to a wide range of hosts. Such adaptations include rapid control of gene expression through the formation of membraneless organelles composed of poly-A RNA and proteins. The African trypanosome Trypanosoma brucei is exquisitely sensitive to well-defined environmental stimuli that trigger cellular adaptations through differentiation events that characterise its complex life cycle. The parasite has been shown to form stress granules in vitro, and it has been proposed that such a stress response could have been repurposed to enable differentiation and facilitate parasite transmission. Therefore, we explored the composition and positional dynamics of membraneless granules formed in response to starvation stress and during differentiation in the mammalian host between the replicative slender and transmission-adapted stumpy forms. We find that T. brucei differentiation does not reflect the default response to environmental stress. Instead, the developmental response of the parasites involves a specific and programmed hierarchy of membraneless granule assembly, with distinct components and regulation by protein kinases such as TbDYRK, that are required for the parasite to successfully progress through its life cycle development and prepare for transmission.
Overcoming low initial coulombic efficiencies of Si anodes through prelithiation in all-solid-state batteries
Authors: Ham So-Yeon , Sebti Elias , Cronk Ashley , Pennebaker Tyler , Deysher Grayson , Chen Yu-Ting , Oh Jin An Sam , Lee Jeong Beom , Song Min Sang , Ridley Phillip , Tan Darren H. S. , Clément Raphaële J. , Jang Jihyun , Meng Ying Shirley 
Published: April 2024

AbstractAll-solid-state batteries using Si as the anode have shown promising performance without continual solid-electrolyte interface (SEI) growth. However, the first cycle irreversible capacity loss yields low initial Coulombic efficiency (ICE) of Si, limiting the energy density. To address this, we adopt a prelithiation strategy to increase ICE and conductivity of all-solid-state Si cells. A significant increase in ICE is observed for Li1Si anode paired with a lithium cobalt oxide (LCO) cathode. Additionally, a comparison with lithium nickel manganese cobalt oxide (NCM) reveals that performance improvements with Si prelithiation is only applicable for full cells dominated by high anode irreversibility. With this prelithiation strategy, 15% improvement in capacity retention is achieved after 1000 cycles compared to a pure Si. With Li1Si, a high areal capacity of up to 10 mAh cm–2 is attained using a dry-processed LCO cathode film, suggesting that the prelithiation method may be suitable for high-loading next-generation all-solid-state batteries.
Rewiring of a KNOXI regulatory network mediated by UFO underlies the compound leaf development in Medicago truncatula
Authors: Lu Zhichao , Zhang Juanjuan , Wang Hongfeng , Zhang Ke , Gu Zhiqun , Xu Yiteng , Zhang Jing , Wang Min , Han Lu , Xiang Fengning , Zhou Chuanen 
Published: April 2024

AbstractClass I KNOTTED-like homeobox (KNOXI) genes are parts of the regulatory network that control the evolutionary diversification of leaf morphology. Their specific spatiotemporal expression patterns in developing leaves correlate with the degrees of leaf complexity between simple-leafed and compound-leafed species. However, KNOXI genes are not involved in compound leaf formation in several legume species. Here, we identify a pathway for dual repression of MtKNOXI function in Medicago truncatula. PINNATE-LIKE PENTAFOLIATA1 (PINNA1) represses the expression of MtKNOXI, while PINNA1 interacts with MtKNOXI and sequesters it to the cytoplasm. Further investigations reveal that UNUSUAL FLORAL ORGANS (MtUFO) is the direct target of MtKNOXI, and mediates the transition from trifoliate to pinnate-like pentafoliate leaves. These data suggest a new layer of regulation for morphological diversity in compound-leafed species, in which the conserved regulators of floral development, MtUFO, and leaf development, MtKNOXI, are involved in variation of pinnate-like compound leaves in M. truncatula.
Artificial kagome lattices of Shockley surface states patterned by halogen hydrogen-bonded organic frameworks
Authors: Yin Ruoting , Zhu Xiang , Fu Qiang , Hu Tianyi , Wan Lingyun , Wu Yingying , Liang Yifan , Wang Zhengya , Qiu Zhen-Lin , Tan Yuan-Zhi , Ma Chuanxu , Tan Shijing , Hu Wei , Li Bin , Wang Z. F. , Yang Jinlong , Wang Bing 
Published: April 2024

AbstractArtificial electronic kagome lattices may emerge from electronic potential landscapes using customized structures with exotic supersymmetries, benefiting from the confinement of Shockley surface-state electrons on coinage metals, which offers a flexible approach to realizing intriguing quantum phases of matter that are highly desired but scarce in available kagome materials. Here, we devise a general strategy to construct varieties of electronic kagome lattices by utilizing the on-surface synthesis of halogen hydrogen-bonded organic frameworks (XHOFs). As a proof of concept, we demonstrate three XHOFs on Ag(111) and Au(111) surfaces, which correspondingly deliver regular, breathing, and chiral breathing diatomic-kagome lattices with patterned potential landscapes, showing evident topological edge states at the interfaces. The combination of scanning tunnelling microscopy and noncontact atomic force microscopy, complemented by density functional theory and tight-binding calculations, directly substantiates our method as a reliable and effective way to achieve electronic kagome lattices for engineering quantum states.
Asymmetric magnetization switching and programmable complete Boolean logic enabled by long-range intralayer Dzyaloshinskii-Moriya interaction
Authors: Liu Qianbiao , Liu Long , Xing Guozhong , Zhu Lijun 
Published: April 2024

AbstractAfter decades of efforts, some fundamental physics for electrical switching of magnetization is still missing. Here, we report the discovery of the long-range intralayer Dzyaloshinskii-Moriya interaction (DMI) effect, which is the chiral coupling of orthogonal magnetic domains within the same magnetic layer via the mediation of an adjacent heavy metal layer. The effective magnetic field of the long-range intralayer DMI on the perpendicular magnetization is out-of-plane and varies with the interfacial DMI constant, the applied in-plane magnetic fields, and the magnetic anisotropy distribution. Striking consequences of the effect include asymmetric current/field switching of perpendicular magnetization, hysteresis loop shift of perpendicular magnetization in the absence of in-plane direct current, and sharp in-plane magnetic field switching of perpendicular magnetization. Utilizing the intralayer DMI, we demonstrate programable, complete Boolean logic operations within a single spin-orbit torque device. These results will stimulate investigation of the long-range intralayer DMI effect in a variety of spintronic devices.
Structure and mechanisms of transport of human Asc1/CD98hc amino acid transporter
Authors: Rullo-Tubau Josep , Martinez-Molledo Maria , Bartoccioni Paola , Puch-Giner Ignasi , Arias Ángela , Saen-Oon Suwipa , Stephan-Otto Attolini Camille , Artuch Rafael , Díaz Lucía , Guallar Víctor , Errasti-Murugarren Ekaitz , Palacín Manuel , Llorca Oscar 
Published: April 2024

AbstractRecent cryoEM studies elucidated details of the structural basis for the substrate selectivity and translocation of heteromeric amino acid transporters. However, Asc1/CD98hc is the only neutral heteromeric amino acid transporter that can function through facilitated diffusion, and the only one that efficiently transports glycine and D-serine, and thus has a regulatory role in the central nervous system. Here we use cryoEM, ligand-binding simulations, mutagenesis, transport assays, and molecular dynamics to define human Asc1/CD98hc determinants for substrate specificity and gain insights into the mechanisms that govern substrate translocation by exchange and facilitated diffusion. The cryoEM structure of Asc1/CD98hc is determined at 3.4–3.8 Å resolution, revealing an inward-facing semi-occluded conformation. We find that Ser 246 and Tyr 333 are essential for Asc1/CD98hc substrate selectivity and for the exchange and facilitated diffusion modes of transport. Taken together, these results reveal the structural bases for ligand binding and transport features specific to human Asc1.
Enhancement resistance to microbiologically influenced stress corrosion of Cu-bearing steel against Bacillus cereus
Authors: Liu Bo , Lu Fangyuan , Zhu Shidong , Du Cuiwei , Li Xiaogang 
Published: April 2024

AbstractMicroorganisms are notoriously known to cause local corrosion and stress corrosion cracking (SCC), which seriously endangers the materials service safety. Cu can enhance antibacterial function of the material and reduce the vulnerability to hydrogen embrittlement (HE). However, the dilemma of how much Cu content generates the best resistance to microbiological corrosion and SCC arises. Here, we modified the Cu content in pipeline steel to obtain the best antibacterial effect to nitrate reducing bacteria Bacillus cereus and HE resistance. The findings offer a fresh perspective on how to design and prepare a steel that are both resistant to microbiological corrosion and SCC.
Gut microbiome is not associated with mild cognitive impairment in Parkinson’s disease
Authors: Aho Velma T. E. , Klee Matthias , Landoulsi Zied , Heintz-Buschart Anna , Pavelka Lukas , Leist Anja K. , Krüger Rejko , May Patrick , Wilmes Paul ,   on behalf of the NCER-PD Consortium, Acharya Geeta , Aguayo Gloria , Alexandre Myriam , Ali Muhammad , Ammerlann Wim , Arena Giuseppe , Bassis Michele , Batutu Roxane , Beaumont Katy , Béchet Sibylle , Berchem Guy , Bisdorff Alexandre , Boussaad Ibrahim , Bouvier David , Castillo Lorieza , Contesotto Gessica , De Bremaeker Nancy , Dewitt Brian , Diederich Nico , Dondelinger Rene , Ramia Nancy E. , Ferrari Angelo , Frauenknecht Katrin , Fritz Joëlle , Gamio Carlos , Gantenbein Manon , Gawron Piotr , Georges Laura , Ghosh Soumyabrata , Giraitis Marijus , Glaab Enrico , Goergen Martine , De Lope Elisa Gómez , Graas Jérôme , Graziano Mariella , Groues Valentin , Grünewald Anne , Hammot Gaël , Hanff Anne-Marie , Hansen Linda , Heneka Michael , Henry Estelle , Henry Margaux , Herbrink Sylvia , Herzinger Sascha , Hundt Alexander , Jacoby Nadine , Jónsdóttir Sonja , Klucken Jochen , Kofanova Olga , Krüger Rejko , Lambert Pauline , Lentz Roseline , Longhino Laura , Lopes Ana Festas , Lorentz Victoria , Marques Tainá M. , Marques Guilherme , Conde Patricia Martins , Mcintyre Deborah , Mediouni Chouaib , Meisch Francoise , Mendibide Alexia , Menster Myriam , Minelli Maura , Mittelbronn Michel , Mtimet Saïda , Munsch Maeva , Nati Romain , Nehrbass Ulf , Nickels Sarah , Nicolai Beatrice , Nicolay Jean-Paul , Noor Fozia , Gomes Clarissa P. C. , Pachchek Sinthuja , Pauly Claire , Pauly Laure , Pavelka Lukas , Perquin Magali , Pexaras Achilleas , Rauschenberger Armin , Rawal Rajesh , Bobbili Dheeraj Reddy , Remark Lucie , Richard Ilsé , Roland Olivia , Roomp Kirsten , Rosales Eduardo , Sapienza Stefano , Satagopam Venkata , Schmitz Sabine , Schneider Reinhard , Schwamborn Jens , Severino Raquel , Sharify Amir , Soare Ruxandra , Soboleva Ekaterina , Sokolowska Kate , Theresine Maud , Thien Hermann , Thiry Elodie , Loo Rebecca Ting Jiin , Trouet Johanna , Tsurkalenko Olena , Vaillant Michel , Vega Carlos , Boas Liliana Vilas , Wilmes Paul , Wollscheid-Lengeling Evi , Zelimkhanov Gelani 
Published: April 2024

AbstractGut microbiome differences between people with Parkinson’s disease (PD) and control subjects without Parkinsonism are widely reported, but potential alterations related to PD with mild cognitive impairment (MCI) have yet to be comprehensively explored. We compared gut microbial features of PD with MCI (n = 58) to cognitively unimpaired PD (n = 60) and control subjects (n = 90) with normal cognition. Our results did not support a specific microbiome signature related to MCI in PD.
The Ethiopian Cognitive Assessment battery in Schizophrenia (ECAS): a validation study
Authors: Gebreegziabhere Yohannes , Habatmu Kassahun , Cella Matteo , Alem Atalay 
Published: April 2024

AbstractCognitive impairment is common in people with schizophrenia (PWS). To detect the presence and its consequences, cognitive measures with sound psychometric properties are needed. However, these are lacking especially in low-income countries. Hence, we developed the Ethiopian Cognitive Assessment battery in Schizophrenia (ECAS). In this study, we evaluated the psychometric properties of the ECAS in a cross-sectional study involving 350 PWS. Confirmatory factor analysis demonstrated a one-factor solution. ECAS score correlated significantly but weakly with a disability measure (r = −0.13, p = 0.02) and symptom dimensions of PANSS (r between −0.12 and −0.29, p < 0.05), except for positive symptoms (r = −0.10, p > 0.05). Years of education (β = 0.12, 95% CI (0.09, 0.14), p < 0.001), male sex (β = 0.22, 95% CI (0.05, 0.39)), age β = −0.02, 95% CI (−0.03, −0.01), and medication side effects (β = −0.03, 95% CI (−0.06, −0.01), p = 0.021) were significantly associated with the composite score of ECAS. The Item Response Theory analysis showed that the tool best functions among participants with moderate cognitive impairment (difficulty coefficient between −1.12 and 0.27). The Differential Item Functioning analyses showed that education had a positive contribution on Digit Symbol Substitution Test (MH OR = 2.64, 95% CI (1.34, 5.20)). The results showed that ECAS is valid in assessing cognition in PWS in low-resource settings.
From home energy management systems to energy communities: methods and data
Authors: Ruano Antonio , Ruano Maria da Graça 
Published: April 2024

AbstractThis paper introduces the HEMStoEC database, which contains data recorded in the course of two research projects,NILMforIHEM, andHEMS2IEA, for more than three years. To be manageable, the dataset is divided in months, from January 2020 until February 2023. It consists in: (a) consumption electric data for four houses in a neighbourhood situated in the south of Portugal, (b) weather data for that location, (c) photovoltaic and battery data, (d) inside climate data, and (e) operation of several electric devices in one of the four houses. Raw data, sampled at 1 sec and 1 minute are available from the different sensing devices, as well as synchronous data, with a common sampling interval of 5 minutes are available. Gaps existing within the data, as well as periods where interpolation was used, are available for each month of data.
Accurate estimation of modulation amplitude in Brillouin optical correlation-domain reflectometry based on Rayleigh noise spectrum
Authors: Kikuchi Keita , Lee Heeyoung , Inoue Ryo , Ozaki Kouta , Sasage Haruki , Mizuno Yosuke 
Published: April 2024

AbstractIn Brillouin optical correlation-domain reflectometry (BOCDR), spatial resolution relies on the modulation amplitude of the light. We propose a Rayleigh-based method that utilizes the spectral width of Rayleigh-induced noise to measure this amplitude without altering the setup or requiring an optical spectrum analyzer. With high frequency resolution and ease of implementation, our approach enhances the convenience and accuracy of spatial resolution evaluation in BOCDR.
The 3-component mixture of power distributions under Bayesian paradigm with application of life span of fatigue fracture
Authors: Abbas Tahir , Tahir Muhammad , Abid Muhammad , Munir Samavia , Ali Sajid 
Published: April 2024

AbstractMixture distributions are naturally extra attractive to model the heterogeneous environment of processes in reliability analysis than simple probability models. This focus of the study is to develop and Bayesian inference on the 3-component mixture of power distributions. Under symmetric and asymmetric loss functions, the Bayes estimators and posterior risk using priors are derived. The presentation of Bayes estimators for various sample sizes and test termination time (a fact of time after that test is terminated) is examined in this article. To assess the performance of Bayes estimators in terms of posterior risks, a Monte Carlo simulation along with real data study is presented.
Cerebrating and engagement, paths to reduce fresh produce waste within homes
Authors: Jansson-Boyd Cathrine V. , Mul Cari-lène , Raeva-Beri Daniela 
Published: April 2024

AbstractA real-world study was conducted with the aim to reduce people’s fresh fruit and vegetables waste within their homes. For 6 weeks participants measured their fresh produce waste. Half the participants were impelled to complete food waste logs whilst the other half was a control group. This was followed by a 6-month monitoring period to establish if changes would last. Fresh produce waste decreased with over a quarter of what the participants had wasted at the beginning of the 6 weeks, for all groups. Additionally, an attitude questionnaire distributed at the onset and at the end of the study showed a shift in pro-reduction of food waste. As this indicated that thinking about food waste prompts engagement, we tested this idea using a different sample group. A questionnaire measuring attitudes and cognition confirmed the importance of thinking and provided further insight into the findings from the first study.