bluuebunny/crossref_metadata_2025_split huggingface dataset:
Disparities in Patient Portal Use Among Adults With Chronic Conditions
Authors: Yoon Esther , Hur Scott , Opsasnick Lauren , Huang Wei , Batio Stephanie , Curtis Laura M. , Benavente Julia Yoshinso , Lewis-Thames Marquita W. , Liebovitz David M. , Wolf Michael S. , Serper Marina 
Published: February 2024

ImportanceDisparities in patient access and use of health care portals have been documented. Limited research has evaluated disparities in portal use during and after the COVID-19 pandemic.ObjectiveTo assess prevalence of health care portal use before, during, and after the most restrictive phase of the pandemic (2019-2022) among the COVID-19 &amp;amp; Chronic Conditions (C3) cohort and to investigate any disparities in use by sociodemographic factors.Design, Setting, and ParticipantsThis cohort study uses data from the C3 study, an ongoing, longitudinal, telephone-based survey of participants with multiple chronic conditions. Participants were middle aged and older-adult primary care patients who had an active portal account, recruited from a single academic medical center in Chicago, Illinois, between 2019 and 2022. Data were analyzed between March and June 2022.Main Outcomes and MeasuresOutcomes of portal use (ie, number of days of portal login by year) were recorded for all study participants by the electronic data warehouse. All parent studies had uniform sociodemographic data and measures of social support, self-efficacy, health literacy, and health activation.ResultsOf 536 participants (mean [SD] age, 66.7 [12.0] years; 336 [62.7%] female), 44 (8.2%) were Hispanic or Latinx, 142 (26.5%) were non-Hispanic Black, 322 (60.1%) were non-Hispanic White, and 20 individuals (3.7%) identified as other race, including Asian, Native American or Alaskan Native, and self-reported other race. In multivariable analyses, portal login activity was higher during the 3 years of the COVID-19 pandemic compared with the 2019 baseline. Higher portal login activity was associated with adequate health literacy (incidence rate ratio [IRR], 1.51; 95% CI, 1.18-1.94) and multimorbidity (IRR, 1.38; 95% CI, 1.17-1.64). Lower portal activity was associated with older age (≥70 years: IRR, 0.69; 95% CI, 0.55-0.85) and female sex (IRR, 0.77; 95% CI, 0.66-0.91). Compared with non-Hispanic White patients, lower portal activity was observed among Hispanic or Latinx patients (IRR, 0.66; 95% CI, 0.49-0.89), non-Hispanic Black patients (IRR, 0.68; 95% CI, 0.56-0.83), and patients who identified as other race (IRR, 0.42; 95% CI, 0.28-0.64).Conclusions and RelevanceThis cohort study using data from the C3 study identified changes in portal use over time and highlighted populations that had lower access to health information. The COVID-19 pandemic was associated with an increase in portal use. Sociodemographic disparities by sex and age were reduced, although disparities by health literacy widened. A brief validated health literacy measure may serve as a useful digital literacy screening tool to identify patients who need further support.
Mortality Risks Over 20 Years in Men With Stage I to III Hormone Receptor–Positive Breast Cancer
Authors: Leone Julieta , Hassett Michael J. , Freedman Rachel A. , Tolaney Sara M. , Graham Noah , Tayob Nabihah , Vallejo Carlos T. , Winer Eric P. , Lin Nancy U. , Leone José P. 
Published: February 2024

ImportanceIn women with hormone receptor–positive (HR+) breast cancer, the risk of distant recurrence and death persists for at least 20 years from diagnosis. The risk of late mortality in men with HR+ breast cancer has not been reported.ObjectiveTo report 20-year risks of breast cancer–specific mortality (BCSM) and non-BCSM in men with stage I to III HR+ breast cancer and identify factors associated with late BCSM.Design, Setting, and ParticipantsAn observational cohort study was conducted of men diagnosed with HR+ breast cancer from 1990 to 2008, using population-based data from the Surveillance, Epidemiology, and End Results program. Men diagnosed with stage I to III HR+ breast cancer were included in the analysis. Cumulative incidence function was used to estimate the outcomes of baseline clinicopathologic variables regarding cumulative risk of BCSM and non-BCSM since diagnosis. Smoothed hazard estimates over time were plotted for BCSM. Fine and Gray multivariable regression evaluated the association of preselected variables with BCSM, conditional on having survived 5 years.Main Outcome MeasureBCSM.ResultsA total of 2836 men with stage I to III HR+ breast cancer were included, with a median follow-up of 15.41 (IQR, 12.08-18.67) years. Median age at diagnosis was 67 (IQR, 57-76) years. The cumulative 20-year risk of BCSM was 12.4% for stage I, 26.2% for stage II, and 46.0% for stage III. Smoothed annual hazard estimates for BCSM revealed an increase in late hazard rates with each incremental node category, reaching a bimodal distribution in N3 and stage III, with each having peaks in hazard rates at 4 and 11 years. Among patients who survived 5 years from diagnosis, the adjusted BCSM risk was higher for those younger than 50 years vs older than 64 years, those with grade II or III/IV vs grade I tumors, and stage II or III vs stage I disease.Conclusions and RelevanceThe findings of this study suggest that, in men with stage I to III HR+ breast cancer, the risk of BCSM persists for at least 20 years and depends on traditional clinicopathologic factors, such as age, tumor stage, and tumor grade. Among men with higher stages of disease, the kinetics of the BCSM risk appear different from the risk that has been reported in women.
Highly Efficient Consolidation of Mesoporous Silica Microstructures Using Photonic Curing
Authors: Trihan Romain , Aimable Anne , Lejeune Martine , Andreazza Pascal , Cattoën Xavier , Rossignol Fabrice 
Published: February 2024

AbstractPhotonic curing offers the advantage of strongly reducing the treatment time of materials, especially for industrial purposes. The current work highlights the benefits of photonic curing for mesoporous silica made by inkjet‐printing. This study shows that appropriate curing treatment allows the preservation of the shape and porosity of mesoporous silica microstructures obtained by inkjet‐printing. Moreover, for the first time, this study demonstrates that photonic curing is compatible with very fragile organic functional groups such as the azide functional groups that enable a versatile functionalization by the copper catalyzed azide‐alkyne cycloaddition (CuAAC) click reaction.
Macroscale TiO2 Microspherical Arrays with Multiple Synergistic Effect for Highly Sensitive Surface‐Enhanced Raman Scattering
Authors: Li Junfang , Xie Qinhui , Li Junbo , Sun Lei , Xie Yunfei , Ozaki Yukihiro , Ji Wei 
Published: February 2024

AbstractSemiconductor materials represent an ideal choice for designing surface‐enhanced Raman scattering (SERS)‐based sensors due to their superior thermal and chemical stability compared to conventional metal materials. However, current SERS‐active semiconductor substrates have limitations such as low detection sensitivity and often complicated preparation steps, which restrict their real‐life applications. In this work, for the first time the feasibility of large‐area fabricating SERS‐active semiconductor substrates based on screen‐printing of micron‐sized TiO2 ink synthesized through a simple flame thermal‐assisted method is demonstrated. The resultant TiO2 microspherical arrays (MSAs) exhibit extraordinary SERS sensitivity with an enhancement factor of 3.28 × 107, which represents one of the highest sensitivity and are the easiest strategy among the reported SERS‐active semiconductor substrates. Both experiments and simulations rationalize the observed enhancement factor and propose that multiple synergistic resonances, including Mie resonance, charge‐transfer resonance, and molecular resonance significantly boost the performance of semiconductor substrates. Dye‐modified TiO2 MSAs are further exploited as the sensing platform for the development of a ratiometric SERS sensor, enabling the highly sensitive, selective, low cost, and stable detection of Hg2+ ions. This study opens up new possibilities for preparing a large‐scale SERS‐active semiconductor array, ultimately advancing the fields of semiconductor‐based SERS sensing technology.
Peripheral Selenium Modification of Multi‐Resonance Thermally Activated Delayed Fluorescence Molecules for High‐Performance Blue Organic Light‐Emitting Diodes
Authors: Jin Jibiao , Wang Shumeng , Jiang He , Wang Lixiang , Wong Wai‐Yeung 
Published: February 2024

AbstractMulti‐resonance thermally activated delayed fluorescence (MR‐TADF) molecules have attracted much attention in the academia owing to their unique photoelectrical properties. However, MR‐TADF emitters usually show slow reverse intersystem crossing (RISC) rate, resulting in high efficiency roll‐off of organic light‐emitting diodes (OLEDs) and seriously limiting their further development. Here, a peripheral selenium (Se) modification is presented for MR‐TADF molecules to promote the RISC process while keeping the narrowband emission for high‐performance blue OLEDs. Compared to the parent molecules (NBN and tBuNBN), SeNBN and SetBuNBN exhibited narrower full‐width at half maximum (FWHM) value of 23 nm and more obvious delayed fluorescence properties with a high efficiency of delayed fluorescence up to 86%, shorter delayed lifetime of 2.4 µs as well as a faster RISC rate of 3.34×105 s−1. Therefore, high‐performance OLEDs based on these two Se modified MR‐TADF emitters are achieved with a high maximum external quantum efficiency (EQE) up to 25.5% and extremely suppressed efficiency roll‐offs of 3.9% at 100 cd m−2 and 24.4% at 1000 cd m−2. This work demonstrated that the introduction of peripheral Se atom can achieve high‐performance organic semiconductors with both narrowband emission and fast RISC rate constant for high‐performance organic optoelectronic devices.
Organic Hole‐Transport Layers: An Innovative Approach for Efficient Perovskite Light‐Emitting Diodes
Authors: Islam Amjad , Shah Syed Hamad Ullah , Haider Zeeshan , Imran Muhammad , Li Ming‐De 
Published: February 2024

AbstractOrganic–inorganic‐halide‐perovskite (OIHP) based light‐emitting diodes (LEDs) are becoming more and more well‐described as having multiple potential uses in lighting and display technology, owing to their broad color gamut and high color purity. Recent research reveals that hole‐transport layers (HTLs) perform crucial roles in realizing high‐performance and highly stable perovskite light‐emitting diodes (PeLEDs). However, the exploration of organic HTLs for obtaining efficient PeLEDs has lagged behind compared to electron‐transport layers. In the past few years, some innovative HTLs have been developed for PeLEDs, which have demonstrated excellent performances in the devices. It has been established that HTL/OIHP interface has a significant impact on the crystallization behaviors and electrical properties of OIHP film. Herein, different types of organic HTLs (polymer/small molecule) used for PeLEDs are discussed. Also, the mechanism of action of those HTLs in perovskite devices is also presented. Moreover, the recent progress of organic HTLs in blue, green, and red PeLED devices is highlighted. Furthermore, the strategies to improve the performance of existing standard HTLs are also reviewed. Additionally, the challenges present in the PeLED technology are briefly summarized. Lastly, viewpoints regarding the ongoing obstacles and forthcoming prospects are emphasized.
Recent Advances and Strategies towards Synthesis of Indolyl and Tryptophan‐C‐Glycoside Scaffolds
Authors: Sangwan Rekha , Azeem Zanjila , Kumar Mandal Pintu 
Published: February 2024

AbstractRecently, C‐glycosidic bonds have emerged as pivotal elementary units present in many naturally occurring alkaloids as well as in pharmaceutically active molecules. Because of the stability and great utility of C‐glycosides, synthetic approaches en route to the C−C bond formation have gradually become a center of attraction in carbohydrate chemistry. Towards these researches, C‐glycosylation with heteroaryl moieties like indole, and tryptophan can remarkably expand the functional and structural evolution, which has great value for medicinal chemists and chemical biologists. The indolyl and tryptophan‐C‐glycosides have unique structures and biological activities that have attracted a number of synthetic studies. Therefore, these motifs have possessed an extensive interest in the direction of efficient synthesis. Herein, this review systematically summarizes the classical approaches to C‐heteroaryl glycosides mainly focusing on indole and tryptophan synthesis. Furthermore, highlighted the recently developed metal‐catalyzed C−H functionalization and photoinduced cross‐coupling strategies that aim to control the regioselectivity and diastereoselectivity of the reaction in carbohydrate chemistry. In view of reaction type, mechanism, and status, this review will cover the synthesis of indole and tryptophan C‐heteroaryl glycosides with diverse regio‐ and diastereoselectivity from four perspectives which include a) conventional approach, b) heterocyclization and C‐glycosylation sequence, c) metal‐catalyzed C−H functionalization, and d) photoinduced cross‐coupling. 1. Introduction 2. Strategies for the synthesis of indolyl and tryptophan‐C‐glycosides 2.1. Conventional approach 2.2. Heterocyclization and C‐glycosylation sequence 2.3. Metal‐catalyzed C−H functionalization 2.4. Photoinduced cross‐coupling 3. Summary and Outlook
Adapting the USDA Food Security Survey Module for use with college students: Can we improve model fit?
Authors: Ellison Brenna , Nguyen Cassandra J. , Rabbitt Matthew P. , French Brian , Bruening Meg 
Published: February 2024

AbstractThe USDA Food Security Survey Module (FSSM) is the gold standard for measuring food security; however, research suggests that college students may respond to FSSM items differently than the general population. Students may have a varied portfolio of food and financial resources (thus, complicating interpretations of “money”) to acquire food. We conducted a randomized control trial to test whether a preamble to address this issue improves model fit. Results indicated the preamble did not improve model fit, and students' responses deviated from expected patterns. More research could help understand these deviations and their implications for measuring FI on college campuses.
Entorhinal‐based path integration selectively predicts midlife risk of Alzheimer's disease
Authors: Newton Coco , Pope Marianna , Rua Catarina , Henson Richard , Ji Zilong , Burgess Neil , Rodgers Christopher T. , Stangl Matthias , Dounavi Maria‐Eleni , Castegnaro Andrea , Koychev Ivan , Malhotra Paresh , Wolbers Thomas , Ritchie Karen , Ritchie Craig W. , O'Brien John , Su Li , Chan Dennis ,   for the PREVENT Dementia Research Programme
Published: February 2024

AbstractINTRODUCTIONEntorhinal cortex (EC) is the first cortical region to exhibit neurodegeneration in Alzheimer's disease (AD), associated with EC grid cell dysfunction. Given the role of grid cells in path integration (PI)–based spatial behaviors, we predicted that PI impairment would represent the first behavioral change in adults at risk of AD.METHODSWe compared immersive virtual reality (VR) PI ability to other cognitive domains in 100 asymptomatic midlife adults stratified by hereditary and physiological AD risk factors. In some participants, behavioral data were compared to 7T magnetic resonance imaging (MRI) measures of brain structure and function.RESULTSMidlife PI impairments predicted both hereditary and physiological AD risk, with no corresponding multi‐risk impairment in episodic memory or other spatial behaviors. Impairments associated with altered functional MRI signal in the posterior‐medial EC.DISCUSSIONAltered PI may represent the transition point from at‐risk state to disease manifestation in AD, prior to impairment in other cognitive domains.
A Novel Homoconjugated Propellane Triimide: Synthesis, Structural Analyses, and Gas Separation
Authors: Chen Yan , Zhao Yongting , Zhao Yubo , Chen Xiangping , Liu Xinyue , Li Lin , Cao Dapeng , Wang Shitao , Zhang Lei 
Published: February 2024

AbstractRigid three‐dimensional (3D) polycyclic propellanes have garnered interest due to their unique conformational spaces, which display great potential use in selectivity, separation and as models to study through‐space electronic interactions. Herein we report the synthesis of a novel rigid propellane, trinaphtho[3.3.3]propellane triimide, which comprises three imide groups embedded on a trinaphtho[3.3.3]propellane. This propellane triimide exhibits large bathochromic shift, amplified molar absorptivity, enhanced fluorescence, and lower reduction potential when compared to the subunits. Computational and experimental studies reveal that the effective through‐space π‐orbitals interacting (homoconjugation) occurs between the subunits. Single‐crystal XRD analysis reveals that the propellane triimide has a highly quasi‐D3h symmetric skeleton and readily crystallizes into different superstructures by changing alkyl chains at the imide positions. In particular, the porous 3D superstructure with S‐shaped channels is promising for taking up ethane (C2H6) with very good selectivity over ethylene (C2H4), which can purify C2H4 from C2H6/C2H4 in a single separation step. This work showcases a new class of rare 3D polycyclic propellane with intriguing electronic and supramolecular properties.
Oligo(phenyleneethynylene)s: Shape‐Tunable Building Blocks for Supramolecular Self‐Assembly
Authors: Fernández Zulema , Sánchez Luis , Santhosh Babu Sukumaran , Fernández Gustavo 
Published: February 2024

AbstractOligo(phenyleneethynylene)s (OPEs) have attracted widespread attention due to their remarkable (opto)electronic and photophysical properties, which have enabled numerous applications. The versatile functionalization possibilities of OPEs make them unique candidates to form various shape‐persistent geometries, including linear, triangular, rectangular, hexagonal and macrocyclic. However, as a result of this structural variety, it is oftentimes challenging to correlate molecular design with self‐assembly properties. In this minireview, we have classified OPEs based on their molecular shapes and correlated them with their self‐assembly behavior in solution. Particularly, we provide important insights into the aggregation propensity of the different molecular shapes and how to tune the association strength using various non‐covalent interactions. Our classification will enable a better understanding of the structure‐property correlation in OPEs, which is key to develop supramolecular functional materials.
Photocatalytic O‐ to S‐Rearrangement of Tertiary Cyclopropanols
Authors: Monteith John J. , Pearson James W. , Rousseaux Sophie A. L. 
Published: February 2024

AbstractDespite the importance of heteroatom‐substituted cyclopropane derivatives in drug design and organic synthesis, cyclopropanethiols remain critically underexplored. Inspired by the wide use of the Newman‐Kwart rearrangement to access valuable thiophenols from phenol feedstocks, we report the development of a photocatalytic approach for efficient ambient temperature aliphatic O‐ to S‐rearrangement on tertiary cyclopropanol derivatives. After demonstrating that a range of cyclopropanethiols—that are difficult to access by other methods—can be obtained with this strategy, we show that these rearranged products can be easily hydrolyzed and further derivatized. We conclude this study with mechanistic findings that enabled an initial extension of this approach toward other classes of aliphatic alcohols.
On‐Water Surface Synthesis of Vinylene‐Linked Cationic Two‐Dimensional Polymer Films as the Anion‐Selective Electrode Coating
Authors: Yang Ye , Sabaghi Davood , Liu Chang , Dianat Arezoo , Mücke David , Qi Haoyuan , Liu Yannan , Hambsch Mike , Xu Zhi‐Kang , Yu Minghao , Cuniberti Gianaurelio , Mannsfeld Stefan C. B. , Kaiser Ute , Dong Renhao , Wang Zhiyong , Feng Xinliang 
Published: February 2024

AbstractVinylene‐linked two‐dimensional polymers (V‐2DPs) and their layer‐stacked covalent organic frameworks (V‐2D COFs) featuring high in‐plane π‐conjugation and robust frameworks have emerged as promising candidates for energy‐related applications. However, current synthetic approaches are restricted to producing V‐2D COF powders that lack processability, impeding their integration into devices, particularly within membrane technologies reliant upon thin films. Herein, we report the novel on‐water surface synthesis of vinylene‐linked cationic 2DPs films (V‐C2DP‐1 and V‐C2DP‐2) via Knoevenagel polycondensation, which serve as the anion‐selective electrode coating for highly‐reversible and durable zinc‐based dual‐ion batteries (ZDIBs). Model reactions and theoretical modeling revealed the enhanced reactivity and reversibility of the Knoevenagel reaction on the water surface. On this basis, we demonstrated the on‐water surface 2D polycondensation towards V‐C2DPs films that show large lateral size, tunable thickness, and high chemical stability. Representatively, V‐C2DP‐1 presents as a fully crystalline and face‐on oriented film with in‐plane lattice parameters of a=b≈43.3 Å. Profiting from its well‐defined cationic sites, oriented 1D channels, and stable frameworks, V‐C2DP‐1 film possesses superior bis(trifluoromethanesulfonyl)imide anion (TFSI−)‐transport selectivity (transference, t_=0.85) for graphite cathode in high‐voltage ZDIBs, thus triggering additional TFSI−‐intercalation stage and promoting its specific capacity (from ~83 to 124 mAh g−1) and cycling life (>1000 cycles, 95 % capacity retention).
Bio‐based pH‐responsive nanofibrous membranes for controlled release of tetracycline hydrochloride
Authors: Zhu Miaomiao , Xu Wenxuan , Wu Duo , Liu Zhuangcheng , Song Yuanyuan , Zhou Aying , Xiong Ranhua , Huang Chaobo 
Published: February 2024

AbstractDesign and fabrication of pH‐responsive nanofibrous membranes by biomaterials is a key step for drug delivery systems. Currently, there is an increasing attention on design of biocompatible nanofibrous drug delivery systems. Here, a bio‐based pH‐responsive nanofibrous membranes loaded with antibiotic were fabricated for the controlled release of tetracycline hydrochloride (TH). The in vitro drug release behavior of varied pH‐responsive nanofibrous with different mass ratios of poly (lactic acid) (PLA) and cellulose acetate phthalate (CAP) was investigated to clarify the release mechanism. TH initial burst release within 20 mins was large than 97.5% for PLA/CAP/TH NFM under alkaline conditions (pH = 8). The antioxidant activity of TH loaded PLA/CAP NFMs are all higher than 55% after 30 mins. The prepared fibrous membranes possess sufficient antibacterial activity against both to Gram‐negative and Gram‐positive bacteria. At the same time, it also has good biocompatibility. Therefore, the fabricated nanofibrous membranes was demonstrated to be a pH‐responsive nanoplatform for drug delivery.