bluuebunny/crossref_metadata_2025_split huggingface dataset:
Type III interferon inhibits bladder cancer progression by reprogramming macrophage-mediated phagocytosis and orchestrating effective immune responses
Authors: Wang Bo , Zhou Bingkun , Chen Junyu , Sun Xi , Yang Wenjuan , Yang Tenghao , Yu Hao , Chen Peng , Chen Ke , Huang Xiaodong , Fan Xinxiang , He Wang , Huang Jian , Lin Tianxin 
Published: April 2024

BackgroundInterferons (IFNs) are essential for activating an effective immune response and play a central role in immunotherapy-mediated immune cell reactivation for tumor regression. Type III IFN (λ), related to type I IFN (α), plays a crucial role in infections, autoimmunity, and cancer. However, the direct effects of IFN-λ on the tumor immune microenvironment have not been thoroughly investigated.MethodsWe used mouse MB49 bladder tumor models, constructed a retroviral vector expressing mouse IFN-λ3, and transduced tumor cells to evaluate the antitumor action of IFN-λ3 in immune-proficient tumors and T cell-deficient tumors. Furthermore, human bladder cancer samples (cohort 1, n=15) were used for immunohistochemistry and multiplex immunoflurescence analysis to assess the expression pattern of IFN-λ3 in human bladder cancer and correlate it with immune cells’ infiltration. Immunohistochemistry analysis was performed in neoadjuvant immunotherapy cohort (cohort 2, n=20) to assess the correlation between IFN-λ3 expression and the pathological complete response rate.ResultsIn immune-proficient tumors, ectopicIfnl3expression in tumor cells significantly increased the infiltration of cytotoxic CD8+T cells, Th1 cells, natural killer cells, proinflammatory macrophages, and dendritic cells, but reduced neutrophil infiltration. Transcriptomic analyses revealed significant upregulation of many genes associated with effective immune response, including lymphocyte recruitment, activation, and phagocytosis, consistent with increased antitumor immune infiltrates and tumor inhibition. Furthermore, IFN-λ3 activity sensitized immune-proficient tumors to anti-PD-1/PD-L1 blockade. In T cell-deficient tumors, increased Ly6G–Ly6C+I-A/I-E+macrophages still enhanced tumor cell phagocytosis inIfnl3overexpressing tumors. IFN-λ3 is expressed by tumor and stromal cells in human bladder cancer, and high IFN-λ3 expression was positively associated with effector immune infiltrates and the efficacy of immune checkpoint blockade therapy.ConclusionsOur study indicated that IFN-λ3 enables macrophage-mediated phagocytosis and antitumor immune responses and suggests a rationale for using Type III IFN as a predictive biomarker and potential immunotherapeutic candidate for bladder cancer.
Monitoring moisture dynamics in multi-layer cover systems for mine tailings reclamation using autonomous and remote time-lapse electrical resistivity tomography
Authors: Dimech Adrien , Bussière Bruno , Cheng LiZhen , Chouteau Michel , Fabien-Ouellet Gabriel , Chevé Nathalie , Isabelle Anne , Wilkinson Paul , Meldrum Philip , Chambers Jonathan 
Published: April 2024

The dynamics of moisture content in cover systems constructed on mining wastes were monitored at the pilot scale using 2D autonomous, remote, and noninvasive time-lapse electrical resistivity tomography combined with conventional point sensors. A methodology was proposed to process the daily hydrogeophysical datasets from 23 m long instrumented sections of covers with capillary barrier effects (CCBEs) designed to act as oxygen barriers, and covers with low saturated hydraulic conductivity layers (LSHCCs) designed to limit the water infiltration rate. Hydrogeophysical monitoring suggested that CCBEs were able to maintain high degrees of saturation in the moisture-retaining layer throughout the 1 year monitoring period, which would make it an efficient oxygen barrier. Larger spatio-temporal changes in moisture content were observed in LSHCCs and most of the low hydraulic conductivity layers remained below 85% saturation, which was attributed to the combined effect of low precipitation, rapid vegetation development, and water percolation through the cover. The methodology proposed in this pilot-scale ”proof-of-concept” study allowed the hydrogeological behavior of the cover systems to be monitored in the 23 m long instrumented sections using continuous geoelectrical data, which demonstrated that this innovative monitoring technique could be useful for geochemical and geotechnical monitoring programs in large-scale mining waste storage facilities.
Efficient and secure semi-quantum private comparison protocol using three-particle GHZ-like states against participant attack
Authors: Yang Chun-Wei , Huang Yu-Yun , Lin Jason , Tsai Chia-Wei 
Published: April 2024

This study identifies a participant attack vulnerability in Li et al.’s SQPC protocol. The participant attack allows a malicious participant, Bob, to obtain the participant Alice’s secret information by intercepting and measuring photons sent to Alice, and later decrypting Alice’s encrypted comparison result. An improved SQPC protocol is proposed to address this problem. The key enhancement is introducing a mutual eavesdropping check requiring the third party and participants to verify they obtain the same photon measurement results. This enables detecting participant attacks like the one identified. The SQPC protocol proposed in this study not only withstands attacks from internal participants but also achieves quantum efficiency almost equivalent to Li et al.’s SQPC protocol. Thus, this study presents a more secure SQPC protocol without compromising quantum efficiency.
PVRL2 Suppresses Antitumor Immunity through PVRIG- and TIGIT-independent Pathways
Authors: Yang Jiuling , Wang Li , Byrnes James R. , Kirkemo Lisa L. , Driks Hannah , Belair Cassandra D. , Aguilar Oscar A. , Lanier Lewis L. , Wells James A. , Fong Lawrence , Blelloch Robert 
Published: April 2024

Abstract
Poliovirus receptor-related 2 (PVRL2, also known as nectin-2 or CD112) is believed to act as an immune checkpoint protein in cancer; however, most insight into its role is inferred from studies on its known receptor, poliovirus receptor (PVR)-related immunoglobulin domain protein (PVRIG, also known as CD112R). Here, we study PVRL2 itself. PVRL2 levels were found to be high in tumor cells and tumor-derived exosomes. Deletion of PVRL2 in multiple syngeneic mouse models of cancer showed a dramatic reduction in tumor growth that was immune dependent. This effect was even greater than that seen with deletion of PD-L1. PVRL2 was shown to function by suppressing CD8+ T and natural killer cells in the tumor microenvironment. The loss of PVRL2 suppressed tumor growth even in the absence of PVRIG. In contrast, PVRIG loss showed no additive effect in the absence of PVRL2. T-cell immunoreceptor with Ig and ITIM domains (TIGIT) blockade combined with PVRL2 deletion resulted in a near complete block in tumor growth. This effect was not recapitulated by the combined deletion of PVRL2 with its paralog, PVR, which is the ligand for TIGIT. These data uncover PVRL2 as a distinct inhibitor of the antitumor immune response with functions beyond that of its known receptor PVRIG. Moreover, the data provide a strong rationale for combinatorial targeting of PVRL2 and TIGIT for cancer immunotherapy.
Actívatexto: Feasibility and Acceptability of a Mobile Intervention That Promotes Smoking Cessation and Physical Activity among Latinos
Authors: Lara Daimarelys , Alaniz-Cantú Edgar I. , Siddalingaiaha Simran , Oliveira Igor , Chávez-Iñiguez Arlette , DeJesus Elisa , Fuller Daniel , Marquez David X. , Vásquez Elizabeth , Li Dongmei , McIntosh Scott , Ossip Deborah J. , Cupertino Ana Paula , Cartujano-Barrera Francisco 
Published: April 2024

Abstract

The purpose of this study was to assess the feasibility and acceptability of a mobile intervention that promotes smoking cessation and physical activity among Latinos living in the United States. Twenty Latino adults who smoked and did not meet recommended levels of physical activity were recruited using community-based recruitment strategies. Participants received Actívatexto, a theory-based, culturally accommodated, 12-week text messaging intervention (available in English and Spanish) that promotes smoking cessation and physical activity. Actívatexto integrates four components: (i) a text messaging program, (ii) a wearable device, (iii) an online dashboard where the research team manages participants’ incoming and outgoing data from both the text messaging program and wearable device, and (iv) nicotine replacement therapies (NRT). We assessed self-reported 7-day point prevalence smoking abstinence at month 3, weekly minutes of moderate to vigorous physical activity (MVPA), pharmacotherapy adherence, and satisfaction. At baseline, participants’ mean age was 47.3 years old (SD 16.0), 55% of participants were female, and 60% indicated that Spanish was their language of preference. Seventy-five percent of participants smoked 1–10 cigarettes daily and 35% smoked their first cigarette within 5 minutes after waking up. At month 3, 14 participants (70%) self-reported 7-day point prevalence smoking abstinence (90% follow-up rate). Fitbit-assessed mean minutes of MVPA per week increased from 113 (SD 127; range: 0–399) at week 1 to 177 (SD 163; range: 0–513) at month 3 (P = 0.15). Sixteen participants (88.9%, 16/18) reported NRT use in the past 90 days. Most participants reported being extremely satisfied or satisfied with the intervention (88.9%, 16/18).

Significance:
Actívatexto resulted in a noteworthy cessation rate at month 3 (70%), increased mean weekly minutes of MVPA, produced high use of NRT, and was well received by participants. Additional testing in a randomized clinical trial is warranted to assess the efficacy of the intervention.
Interpréter le Coran versus défendre le muṣḥaf : l’exemple du verset 2, 184c
Authors: Benkheira Hocine 
Published: April 2024

Résumé
La lecture du verset 2, 184c (wa-ʿalā llaḏīna yuṭīqūna-hu fidyatun ṭaʿāmu miskīnin) retenue dans le codex (muṣḥaf) a confronté les exégètes à des problèmes difficiles à surmonter. C’est ainsi qu’ils ont été conduits à en proposer plusieurs interprétations, dont une en particulier a recueilli l’assentiment de beaucoup d’entre eux et a été adoptée par les premières autorités du tafsīr (Muqātil b. Sulaymān, Abū ʿUbayd, al-Ṭabarī) alors même qu’elle s’écarte ouvertement de l’énoncé. On s’efforce ici de comprendre les raisons de ce choix, en apparence aberrant.
Lorsqu’un uṣūlī interprète le Coran : aspects de la réception de la théorie légale dans l’exégèse de Faḫr al-Dīn al-Rāzī
Authors: Oulddali Ahmed 
Published: April 2024

Résumé
Dans son commentaire coranique, Faḫr al-Dīn al-Rāzī met à contribution diverses sciences traditionnelles et rationnelles, parmi lesquelles les fondements du droit (uṣūl al-fiqh). Cette discipline joue un rôle primordial au sein de son dispositif exégétique, puisqu’il y puise beaucoup de notions et d’arguments lui permettant de proposer de nouvelles interprétations ou de réfuter les opinions émises par ses prédécesseurs. Le présent travail vise à étudier l’apport des fondements du droit à l’exégèse de Faḫr al-Dīn al-Rāzī. Il s’agit de montrer comment cet auteur utilise les règles herméneutiques empruntées à la science des uṣūl al-fiqh et les profits qu’il en tire, notamment dans les débats l’opposant aux autres commentateurs du Coran.
A Nonlinear Full-Field Conceptual Model for ENSO Diversity
Authors: Fang Xianghui , Dijkstra Henk , Wieners Claudia , Guardamagna Francesco 
Published: April 2024

Abstract
As the strongest year-to-year fluctuation of the global climate system, El Niño–Southern Oscillation (ENSO) exhibits spatial–temporal diversity, which challenges the classical ENSO theories that mainly focus on the canonical eastern Pacific (EP) type. Besides, the complicated interplay between the interannual anomaly fields and the decadally varying mean state is another difficulty in current ENSO theory. To better account for these issues, the nonlinear two-region recharge paradigm model is extended to a three-region full-field conceptual model to capture the physics in the western Pacific (WP), central Pacific (CP), and EP regions. The results show that the extended conceptual model displays a rich dynamical behavior as parameters setting the efficiencies of upwelling and zonal advection are varied. The model can not only generate El Niño bursting behavior but also simulate the statistical asymmetries between the two types of El Niños and the warm and cold phases of ENSO. Finally, since both the anomaly fields and mean states are simulated by the model, it provides a simple tool to investigate their interactions. The strengthening of the upwelling efficiency, which can be seen as an analogy to a cooling thermocline associated with the oceanic tunnel to the midlatitudes, will increase the zonal gradient of the mean state temperature between the WP and EP, i.e., resembling a negative Pacific decadal oscillation (PDO) pattern along the equatorial Pacific. The influence of the zonal advection efficiency is quite the opposite, i.e., its strengthening will reduce the zonal gradient of the mean state temperature along the equatorial Pacific.
Impacts of Initial Condition Perturbation Blending in 10- and 40-Member Convection-Allowing Ensemble Forecasts
Authors: Johnson Aaron , Wang Xuguang 
Published: April 2024

Abstract
A series of convection-allowing 36-h ensemble forecasts during the 2018 spring season are used to better understand the impacts of ensemble configuration and blending different sources of initial condition (IC) perturbation. Ten- and forty-member ensemble configurations are initialized with the multiscale IC perturbations generated as a product of convective-scale data assimilation (MULTI) and initialized with the MULTI IC perturbations blended with IC perturbations downscaled from coarser-resolution ensembles (BLEND). The forecast performance of both precipitation and nonprecipitation variables is consistently improved by the larger ensemble size. The benefit of the larger ensemble is largely, but not entirely, due to compensating for underdispersion in the fixed-physics ensemble configuration. A consistent improvement in precipitation forecast skill results from blending in the 10-member ensemble configuration, corresponding to a reduction in the ensemble calibration error (i.e., reliability component of Brier score). In the 40-member ensemble configuration, the advantage of blending is limited to the ∼18–22-h lead times at all precipitation thresholds and the ∼35–36-h lead times at the lowest threshold, both corresponding to an improved resolution component of the Brier score. The advantage of blending in the 40-member ensemble during the diurnal convection maximum of ∼18–22-h lead times is primarily due to cases with relatively weak synoptic-scale forcing, while advantages at later lead times beyond ∼30-h lead time are most prominent on cases with relatively strong synoptic-scale forcing. The impacts of blending and ensemble configuration on forecasts of nonprecipitation variables are generally consistent with the impacts on the precipitation forecasts.
Race/Ethnicity and Social Determinants of Health and Their Impact on Receiving Appropriate Chemotherapy for Colon Cancer
Authors: Dobbs Erica , Tobin Edward C. , Deslich Staci , Richmond Bryan K. 
Published: April 2024

Introduction Despite the heightened understanding and improved treatment for colorectal cancer in the United States, social determinants of health (SDH) play a significant role in the colorectal cancer outcomes. We sought to investigate the relationship between SDH and appropriate utilization of adjuvant chemotherapy in stage III colon cancer. Methods For this retrospective study, we utilized data from the National Cancer Data Base (NCDB). Descriptive statistics are reported, including means and 95% confidence intervals for continuous variables and frequency and proportions for categorical variables. Univariate hypothesis testing to identify categorical level factors associated with treatment used Wilcoxon rank sum or Kruskal-Wallis tests, with multivariate analyses performed using regression analysis. Results Significant differences were as follows: Metro-non-Hispanic White patients received treatment less frequently (69.7%) when compared to Metro-non-Hispanic Black patients (73.4%) ( P < .001). Increasing age was a negative predictor of likelihood to receive with those over 65 years old having an 83% decrease in likelihood to receive chemotherapy when compared to those under 65 ( P < .001). Medicaid patients were 47% less likely and Medicare patients were 40% less likely to receive chemotherapy when compared to those with private insurance ( P < .001). Rural patients were statistically more likely to receive chemotherapy (OR 1.42, 1.32-2.52, P < .001) as were urban patients, (OR 1.26, 1.20-1.31, P < .001) when compared to patients residing in metro areas. Conclusion Age, living in a Metro area, and government insurance status at diagnosis are negatively correlated with the likelihood of receiving chemotherapy. Race was not associated with differences in receiving chemotherapy.
Implementation of a Trauma Bay Checklist Improves Antibiotic Prophylaxis Compliance in Open Extremity Fractures
Authors: Luke Robert D. , Balio Casey P. , Foley Claire K. , Soult Alexa P. 
Published: April 2024

Background Best practice guidelines from the ACS recommend that patients with open fractures receive antibiotics within 1-hour of presentation. Checklists are effective mechanisms for improving safety and compliance in surgical settings. The current study investigates implementation of a trauma bay checklist, referred to as MARTY, to improve administration of antibiotics in open extremity fractures at a level I trauma center. Methods Retrospective pre-post design. Population consisted of trauma alerts from January to December 2021 (pre-MARTY) and 2022 (post-MARTY) with open fractures. Outcome measures included antibiotics administered within 1-hour of presentation and in the trauma bay. Bivariate and multivariate analyses were performed to estimate differences in both measures. Results Our sample included 339 encounters, 174 pre-MARTY and 165 post-MARTY implementation. In the pre-MARTY period, 57.5% of encounters received antibiotics within 1-hour of presentation with 46.0% occurring in the trauma bay, in comparison to 65.5% and 54.5% in the post-MARTY period. In adjusted models, there were greater odds of antibiotic administration within 1-hour (OR = 1.654, P = .038) and prior to leaving the trauma bay (OR = 1.660, P = .041) than pre-MARTY. Encounters with higher-grade fractures were more likely to receive timely antibiotics ( P<=.001). Discussion Our study estimates improved compliance of antibiotic administration after implementation of MARTY after adjusting for encounter characteristics. Findings from this study demonstrate improved compliance, but this compliance is often still lacking in those with higher injury severity scores. Findings from this study may be used to inform approaches to further improve trauma care.
PAN-based fiber-reinforced carbon-carbon composites for improved fire retardancy and thermal and electrical conductivities for harsh environments
Authors: Murali TKS , Murad Md Shafinur , Bakir Mete , Asmatulu Ramazan 
Published: April 2024

Carbon-carbon (C-C) fiber composites are a new class of materials that are used in various industries due to their exceptional chemical, thermal and electrical conductivities properties. In this study, carbon-carbon fiber composites were manufactured where polyacrylonitrile (PAN) powder was dissolved in dimethylformamide (DMF) solution, and carbon fibers with desired concentrations (20–80 wt%) were immersed into this solution as reinforcement through evaporation and solidification. The PAN-fiber systems were then stabilized at 250–270°C for 120 min in the air and subsequently carbonized at 650, 750, and 850°C for 60 min in the presence of argon gas to obtain the desired C-C fiber composites. Thermogravimetric analysis (TGA) results showed that the carbonized samples had a small weight loss of 2.5%, while actual and oxidized samples had more weight loss. Moreover, the carbonized sample surface was more hydrophobic compared to other samples due to the carbon presence and surface texture changes. Fourier-Transform Infrared (FTIR) spectroscopy peaks showed the presence of different functional groups of PAN before oxidation and carbonization, but those peaks disappeared after oxidation and carbonization. The developed carbon-carbon composite passed the UL94 vertical flame retardancy testing with a V-0 rating. Surface smoothness, proper matrix and reinforcements bonding were confirmed by scanning electron microscopy (SEM) results and the manufactured composite properties changes were validated by the confocal microscopy images. The carbon-carbon fiber composite achieved an electrical conductivity value up to 4.75 × 103 S/m after the carbonization process. The excellent thermal, chemical, and electrical properties of these composites can be useful for numerous industrial applications in different extreme environments.
Capturing Valuation Study Sampling Uncertainty in the Estimation of Health State Utility Values Using the EQ-5D-3L
Authors: Poulimenos Spyridon , Round Jeff , Baio Gianluca 
Published: April 2024

Objectives Utility scores associated with preference-based health-related quality-of-life instruments such as the EQ-5D-3L are reported as point estimates. In this study, we develop methods for capturing the uncertainty associated with the valuation study of the UK EQ-5D-3L that arises from the variability inherent in the underlying data, which is tacitly ignored by point estimates. We derive a new tariff that properly accounts for this and assigns a specific closed-form distribution to the utility of each of the 243 health states of the EQ-5D-3L. Methods Using the UK EQ-5D-3L valuation study, we used a Bayesian approach to obtain the posterior distributions of the derived utility scores. We constructed a hierarchical model that accounts for model misspecification and the responses of the survey participants to obtain Markov chain Monte Carlo (MCMC) samples from the posteriors. The posterior distributions were approximated by mixtures of normal distributions under the Kullback–Leibler (KL) divergence as the criterion for the assessment of the approximation. We considered the Broyden–Fletcher–Goldfarb–Shanno (BFGS) algorithm to estimate the parameters of the mixture distributions. Results We derived an MCMC sample of total size 4,000 × 243. No evidence of nonconvergence was found. Our model was robust to changes in priors and starting values. The posterior utility distributions of the EQ-5D-3L states were summarized as 3-component mixtures of normal distributions, and the corresponding KL divergence values were low. Conclusions Our method accounts for layers of uncertainty in valuation studies, which are otherwise ignored. Our techniques can be applied to other instruments and countries’ populations. Highlights Guidelines for health technology assessments typically require that uncertainty be accounted for in economic evaluations, but the parameter uncertainty of the regression model used in the valuation study of the health instrument is often tacitly ignored. We consider the UK valuation study of the EQ-5D-3L and construct a Bayesian model that accounts for layers of uncertainty that would otherwise be disregarded, and we derive closed-form utility distributions. The derived tariff can be used by researchers in economic evaluations, as it allows analysts to directly sample a utility value from its corresponding distribution, which reflects the associated uncertainty of the utility score.