bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metabolic adaptations determine whether natural killer cells fail or thrive within the tumor microenvironment
Authors: Moinuddin Adnan , Poznanski Sophie M. , Portillo Ana L. , Monteiro Jonathan K. , Ashkar Ali A. 
Published: March 2024

SummaryNatural Killer (NK) cells are a top contender in the development of adoptive cell therapies for cancer due to their diverse antitumor functions and ability to restrict their activation against nonmalignant cells. Despite their success in hematologic malignancies, NK cell‐based therapies have been limited in the context of solid tumors. Tumor cells undergo various metabolic adaptations to sustain the immense energy demands that are needed to support their rapid and uncontrolled proliferation. As a result, the tumor microenvironment (TME) is depleted of nutrients needed to fuel immune cell activity and contains several immunosuppressive metabolites that hinder NK cell antitumor functions. Further, we now know that NK cell metabolic status is a main determining factor of their effector functions. Hence, the ability of NK cells to withstand and adapt to these metabolically hostile conditions is imperative for effective and sustained antitumor activity in the TME. With this in mind, we review the consequences of metabolic hostility in the TME on NK cell metabolism and function. We also discuss tumor‐like metabolic programs in NK cell induced by STAT3‐mediated expansion that adapt NK cells to thrive in the TME. Finally, we examine how other approaches can be applied to enhance NK cell metabolism in tumors.
Recovery‐oriented practice in a hospital mental health service
Authors: Lorien Leonie M. , Arthur Michael , Keiler Katherine , Lowry Joanne , Ryan Kathleen 
Published: March 2024

AbstractAs part of mental health reform in Australia, new policies were introduced to support recovery‐oriented practice; however, little has changed in hospital settings focused on managing risk and remediating acute symptoms. Previous studies have indicated that patients' experiences of personal recovery, during a hospital admission, may not mirror that of people living in the community, with patients being more likely to experience disconnection, hopelessness and disempowerment. Using a Participatory Health Research approach, eight mental health professionals, a patient advocate and an external researcher formed a research partnership to answer the question: How can staff enhance recovery‐oriented practice in a hospital‐based mental health service? The COREQ checklist was used for reporting the methods, analysis and findings. The methods comprised patient focus groups (n = 16 participants), interviews with managers (n = 7) and an online survey for staff (n = 17). Researchers analysed the feedback from the consultations using inductive thematic analysis, identifying two themes: relational recovery and recovery interventions. The findings indicate that relational recovery is key to recovery during a hospital admission and interventions that increase connectedness or reduce the impact of symptoms enhance personal recovery.
An audit and analysis of electro convulsive therapy patient information sheets used in local health districts in New South Wales Australia
Authors: Wand Timothy , Isobel Sophie , Kemp Holly 
Published: March 2024

AbstractElectroconvulsive Therapy (ECT) is a widely used psychiatric treatment; however, it remains contentious. It is therefore important that people are provided with accurate and balanced information before consenting to ECT. The aim of this study was to audit and analyse the content and language of ECT information sheets used in local health districts (LHDs) across the state of New South Wales Australia. Descriptive content analysis and evaluative linguistic analysis were used to investigate the information sheets, with findings then considered from a mad studies perspective. Thirteen ECT information sheets were obtained and reviewed, with the audit finding they lacked accuracy and balance. Linguistic tools were used to exaggerate positive outcomes and minimise negative effects. Despite commonalities, the structure and content of the sheets varied considerably. Findings indicate a need for co‐design and co‐production approaches to developing ECT information sheets. This should occur in genuine partnership with lived experience representatives based on current evidence, using neutral language, and with attention to their intent as part of processes of informed consent and decision making.
Niche position accounts for the positive occupancy–abundance relationship of lake fishes
Authors: Xia Zhijun , Heino Jani , Wang Jianwei , Chang Tao , Li Mingzheng 
Published: March 2024

AbstractAimIf the positive occupancy–abundance relationship prevails, locally abundant species are widely distributed. Although broadly supported, studies on lake fishes have thus far contributed little to this topic, especially at intermediate and small spatial scales. Here, the main objective was to investigate the relationship between occupancy and abundance of lake fish species within a large lake, as well as examine the relative importance of ecological niches, functional traits and phylogenetic relatedness in forming the relationship.LocationPoyang Lake, China.TaxonFishes.MethodsWe calculated occupancy and mean abundance for 78 fish species and estimated niche position and niche breadth for each species based on a set of environmental variables. Additionally, we generated four functional trait vectors and one phylogenetic vector, describing trait similarity and phylogenetic relatedness, respectively. Linear models, hierarchical partitioning analyses and boosted regression trees were used in combination to explore the relative role of niche position, niche breadth, trait vectors and phylogenetic relatedness in determining fish occupancy, abundance and their relationship.ResultsOccupancy and mean abundance of fish species in Poyang Lake showed a significantly positive and rather strong interspecific relationship. Interspecific variations in fish occupancy and abundance were well accounted for by niche position, followed by niche breadth. Nonetheless, trait vectors and phylogenetic relatedness were of minor importance in affecting fish occupancy and abundance. Additionally, occupancy was better explained than abundance by the predictor variables used, which was shown by both linear models and boosted regression trees.Main ConclusionsThis study suggests that the positive correlation between occupancy and abundance also occurs in lake fish species. Furthermore, ecological niche features, especially niche position, were more important than functional traits and phylogenetic relatedness in accounting for occupancy and abundance of fish species in Poyang Lake.
Eco‐evolutionary evidence for the global diversity pattern of Cycas (Cycadaceae)
Authors: Liu Jian , Lindstrom Anders J. , Gong Yiqing , Dong Shanshan , Liu Yusheng (Chris) , Zhang Shouzhou , Gong Xun 
Published: March 2024

ABSTRACTThe evolution of the latitudinal diversity gradient (LDG), characterized by a peak in diversity toward the tropics, has captured significant attention in evolutionary biology and ecology. However, the inverse LDG (i‐LDG) mechanism, wherein species richness increases toward the poles, remains inadequately explored. Cycads are among one of the oldest lineages of extant seed plants and have undergone extensive diversification in the tropics. Intriguingly, the extant cycad abundance exhibits an i‐LDG pattern, and the underlying causes for this phenomenon remain largely elusive. Here, using 1,843 nuclear genes from a nearly complete sampling, we conducted comprehensive phylogenomic analyses to establish a robust species‐level phylogeny for Cycas, the largest genus within cycads. We then reconstructed the spatial‐temporal dynamics and integrated global environmental data to evaluate the roles of species ages, diversification rates, contemporary environment, and conservatism to ancestral niches in shaping the i‐LDG pattern. We found Cycas experienced decreased diversification rates, coupled with the cooling temperature since its origin in the Eocene from continental Asia. Different regions have distinctively contributed to the formation of i‐LDG for Cycas, with the northern hemisphere acting as evolutionary museums and the southern hemisphere serving as cradles. Moreover, water‐related climate variables, specifically precipitation seasonality and potential evapotranspiration, were identified as paramount factors constraining Cycas species richness in the rainforest biome near the equator. Notably, the adherence to ancestral monsoonal climates emerges as a critical factor in sustaining the diversity pattern. This study underscores the imperative of integrating both evolutionary and ecological approaches to comprehensively unravel the mechanisms underpinning global biodiversity patterns.
Macroeconomic effects of a declining wage share: A meta‐analysis of the functional income distribution and aggregate demand
Authors: Dammerer Quirin , List Ludwig , Rehm Miriam , Schnetzer Matthias 
Published: March 2024

AbstractThis paper reviews the theoretical and empirical literature on the relationship between the functional distribution of income and aggregate demand, which investigates whether declining wage shares increase (“profit‐led”) or decrease (“wage‐led”) demand. It conducts a meta‐regression analysis of 33 studies with 578 estimates for total and domestic demand, covering up to 163 years and 59 countries and regions. Our results suggest that, on average and across all countries, total demand is predominantly profit‐led and domestic demand mainly wage‐led. The effects in the literature range between 0.8 and −0.3 within one standard deviation for domestic demand and between 0.4 and −0.7 for total demand, which are economically significant at the outer bounds. We find mixed evidence for publication selectivity, which may affect the size but not the direction of the results in the literature. If one was to nonetheless correct for this, then total demand would be less profit‐led or statistically insignificant. A set of moderator variables, including publication characteristics, estimation strategies, the covariates included in the studies’ estimation functions, and, in particular, controls for time and space, help explain the variation in the empirical estimates.
Sustainable innovations, knowledge and the role of proximity: A systematic literature review
Authors: Wilke Ulrich , Pyka Andreas 
Published: March 2024

AbstractInnovations can substantially contribute to the transformation toward sustainability if they induce a positive social and/or environmental impact. Such sustainable innovations differ considerably from conventional, purely economic innovations. The main difference stems from the different knowledge bases necessary for the development of these innovations. These knowledge bases are widely dispersed across different actors from business, academia, government, and civil society. Following the innovation system approach, we look at actor constellations, linkages between actors, and knowledge flows within networks that generate sustainable innovations. For this purpose, we conduct a systematic literature review, focusing on the concept of proximity and its five dimensions (geographical, cognitive, institutional, organizational, and social proximity). The results show that all proximity dimensions, as well as the interdependencies between them, are relevant for analyzing knowledge flows leading to sustainable innovations. The interplay of the different proximity dimensions can be described via two mechanisms, one being reinforcement and the other one being either substitution or overlap. We conclude that for the occurrence of radical, systemic innovations, which have the potential of altering the prevailing socio‐economic paradigm toward greater sustainability, a combination of low cognitive and low (micro‐) institutional proximity combined with high organizational, social, or geographical proximity, appears particularly conducive.
Masticatory function in edentulous patients wearing implant overdentures after graftless maxillary sinus membrane elevation
Authors: Lie Suen A. N. , Speksnijder Caroline M. , Kalic Haris , Kessler Peter A. W. H. 
Published: March 2024

AbstractBackgroundGraftless sinus floor augmentation shows good results in bone gain, radiology and implant survival. Clinically, this technique can be recommended as an alternative to conventional procedures using augmentation materials.ObjectivesThis study aims to assess masticatory performance, masticatory ability and patient satisfaction after graftless sinus floor augmentation.MethodsThe study group consisted of patients who had received a graftless sinus lift procedure in a split‐mouth design and was compared to patients with maxillary implant‐supported overdentures without augmentation and a natural dentition group. To assess objective masticatory performance, the mixing ability test was performed. Three questionnaires were used to assess patient reported outcomes related to mastication and patient satisfaction.ResultsEach group included ten patients. Both the graftless sinus lift group and the edentulous control group had a worse masticatory performance compared to the natural dentition group. Masticatory ability, measured by patient reported outcomes, was not different between the graftless sinus floor augmentation group and implant‐retained overdentures group without augmentation, but the natural dentition group showed better results. Thereby, the better the masticatory performance in patients with a graftless sinus membrane elevation the better the patient satisfaction for ‘prosthesis’, ‘appearance of prostheses’, ‘speech’ and ‘mastication and eating’.ConclusionsPatients with implant‐supported overdentures show inferior masticatory function compared to those with natural dentition. There were no significant differences in masticatory performance between patients with implant‐retained overdentures, with or without graftless augmentation. The decision on the preferred procedure should consider additional factors such as anatomical, surgical‐technical aspects and patient's preferences.
The futility of post‐haemodialysis blood glucose levels: A retrospective cohort study
Authors: Zhang Jing , Le Leu Richard K. , Xu Qunyan , Bennett Paul 
Published: March 2024

AbstractBackgroundFrequent blood glucose tests are performed for people with diabetes receiving haemodialysis.ObjectivesTo determine the rate of out‐of‐range post‐haemodialysis blood glucose levels that are clinically acted upon, the intervention and outcome of each intervention, and the associations between post‐haemodialysis blood glucose levels and relevant clinical predictors.Design12‐month retrospective cohort medical record review in one Australian haemodialysis centre. Post‐haemodialysis blood glucose levels, prehaemodialysis blood glucose levels, time of treatment, diabetes medications, intradialytic fluid removal, dialysate dextrose concentration, clinical actions, interventions, and outcomes on out‐of‐range blood glucose levels were retrieved.Participants22 participants with a median time receiving dialysis 3.1 years (interquartile range 2.3−4.7).Measurements and ResultsThe proportion of out‐of‐range post‐haemodialysis blood glucose levels was 87.3% (95% confidence interval, 86.1%−88.5%). No out‐of‐range post‐haemodialysis blood glucose levels were clinically acted upon. Out‐of‐range post‐haemodialysis blood glucose levels were 4.6 times more likely if a higher dextrose bath was used (95% confidence interval: 3.3; 6.3. p < 0.001). The odds of the post‐haemodialysis blood glucose levels increased by each 1 mmol/L. Intradialytic fluid removal, dialysate dextrose concentration, sex, dialysis time, anti‐hyperglycaemic agents were also associated with out‐of‐range post‐haemodialysis blood glucose levels.ConclusionRoutine post‐haemodialysis blood glucose levels testing has limited clinical utility in care for people with diabetes receiving maintenance haemodialysis. Higher dextrose dialysate may require individual titration depending on prehaemodialysis blood glucose levels.
The Bryophyte Phylogeny Group: A revised familial classification system based on plastid phylogenomic data
Authors: Li Yun‐Feng , Luo Lian , Liu Yang , He Qiang , Yu Ning‐Ning , Gaowa Naren , Yi Zhao‐Qin , Wang Jun‐Jie , Han Wei , Peng Tao , Ho Boon‐Chuan , He Xiaolan , Zhang Li , Chen Zhi‐Duan , Jia Yu , Wang Qing‐Hua 
Published: March 2024

AbstractBryophytes, a monophyletic group comprising three major lineages, diversified soon after the terrestrialization of land plants. However, their internal phylogenetic relationships remain controversial. In this study, we reconstructed the ordinal and familial phylogeny of bryophytes using the largest plastid data set to date, including 549 taxa that represent almost all known orders and two‐thirds of families. The strongly supported phylogenetic inference enabled us to propose in mosses seven newly segregated families, that is, Baldwiniellaceae, Calyptrochaetaceae, Ctenidiaceae, Herpetineuraceae, Isodrepaniaceae, Pseudotaxiphyllaceae, and Rozeaceae, and one reduced family, that is, Climaciaceae. We also transferred the liverwort family Calyculariaceae from Fossombroniales to Pelliales. Recent advancements in molecular phylogeny have revolutionized bryophyte classification, tending to be more fragmental. Hence, we further propose a revised familial classification system for bryophytes that includes 45 orders and 142 families in mosses, 23 orders and 85 families in liverworts, and five orders and five families in hornworts.
Productivity versus environmental sustainability: A broadscale assessment of freshwater aquaculture's technical efficiency and ecological efficiency in China's inland provinces
Authors: Wang Zhina , Chen Xuan , Shi Longzhong , Zhang Xiaoheng , Hu Yijuan 
Published: March 2024

AbstractPromoting the productivity and environmental sustainability of aquaculture is critical in ensuring its healthy development. This study assesses freshwater aquaculture's technical efficiency and ecological efficiency in China's 19 inland provinces from 2008 to 2019, aiming to reveal its productivity and environmental sustainability status. We employ the three‐stage Data Envelopment Analysis‐CCR (T‐DEA‐CCR) and three‐stage Slack‐Based Measure‐DEA (T‐SBM‐DEA) methods to explore the technical efficiency and the ecological efficiency while accounting for environmental conditions and random errors. The average technical efficiency and ecological efficiency during 2008–2019 are 0.857 and 0.702, respectively, indicating substantial scope for enhancing the productivity and environmental sustainability of China's inland aquaculture. We further investigate the regional development using the club convergence, finding that the provincial‐level technical efficiencies have already achieved population convergence while the ecological efficiencies diverge into two clubs, suggesting that Chinese freshwater aquaculture's productivity and environmental sustainability have different development pathways. Acknowledging the pivotal roles of environmental protection and growers' training in aquaculture's productivity and environmental sustainability, policymakers may institute funding and recognition to foster the adoption of innovative, environmentally responsible practices by operators.
Genome‐wide association analysis reveals genes controlling an antagonistic effect of biotic and osmotic stress on Arabidopsis thaliana growth
Authors: Huang Pingping , El‐Soda Mohamed , Wolinska Katarzyna W. , Zhao Kaige , Davila Olivas Nelson H. , van Loon Joop J. A. , Dicke Marcel , Aarts Mark G. M. 
Published: March 2024

AbstractWhile the response of Arabidopsis thaliana to drought, herbivory or fungal infection has been well‐examined, the consequences of exposure to a series of such (a)biotic stresses are not well studied. This work reports on the genetic mechanisms underlying the Arabidopsis response to single osmotic stress, and to combinatorial stress, either fungal infection using Botrytis cinerea or herbivory using Pieris rapae caterpillars followed by an osmotic stress treatment. Several small‐effect genetic loci associated with rosette dry weight (DW), rosette water content (WC), and the projected rosette leaf area in response to combinatorial stress were mapped using univariate and multi‐environment genome‐wide association approaches. A single‐nucleotide polymorphism (SNP) associated with DROUGHT‐INDUCED 19 (DI19) was identified by both approaches, supporting its potential involvement in the response to combinatorial stress. Several SNPs were found to be in linkage disequilibrium with known stress‐responsive genes such as PEROXIDASE 34 (PRX34), BASIC LEUCINE ZIPPER 25 (bZIP25), RESISTANCE METHYLATED GENE 1 (RMG1) and WHITE RUST RESISTANCE 4 (WRR4). An antagonistic effect between biotic and osmotic stress was found for prx34 and arf4 mutants, which suggests PRX34 and ARF4 play an important role in the response to the combinatorial stress.
Possible association between oral health status and appetite loss in community‐dwelling older adults
Authors: Inoue Subaru , Suma Shino , Furuta Michiko , Wada Naohisa , Yamashita Yoshihisa 
Published: March 2024

AbstractThis study aimed to evaluate the association between the oral health status and appetite in community‐dwelling older adults. We enrolled 100 people aged ≥65 years who had participated in long‐term care prevention projects between December 2018 and January 2019. Appetite was assessed using the Council on Nutrition Appetite Questionnaire score. The oral health status was assessed based on the number of teeth, occlusal condition, swallowing function, tongue coating, and the Oral Health Assessment Tool. A multiple linear regression analysis was performed with appetite as the dependent variable and each variable related to oral health status as an independent variable. The analysis was adjusted for sex, age, activities of daily living, cognitive function, smoking habit, and alcohol consumption. Dental pain was associated with poor appetite in community‐dwelling older adults. No other oral health status parameter was associated with appetite. Thus, controlling dental pain is critical to prevent appetite loss while considering other factors.