bluuebunny/crossref_metadata_2025_split huggingface dataset:
Second malignant neoplasms within 5 years from first primary diagnosis in pediatric oncology patients in Canada: a population-based retrospective cohort study
Authors: Ricci Christina , Subburaj Divya , Lim Kate , Shukla Neetu , Kaur Jaskiran , Xie Lin , Laverty Meghan , Zakaria Dianne , Pole Jason , Pelland-Marcotte Marie-Claude , Barber Randy , Israels Sara J. , Tran Thai-Hoa , Oberoi Sapna , Renzi Samuele , MacDonald Tamara , Sung Lillian , Kulkarni Ketan 
Published: March 2024

IntroductionFrom the advancement of treatment of pediatric cancer diagnosis, the five-year survival rate has increased significantly. However, the adverse consequence of improved survival rate is the second malignant neoplasm. Although previous studies provided information on the incidence and risk of SMN in long term survivors of childhood cancer, there is still scarce information known for short term (&lt; 5 years) prognosis. This study aims to assess the incidence, characteristics, management, and outcome of children who develop SMN malignancies within 5 years of diagnosis of their initial cancer.MethodThis is a retrospective cohort study of early Second Malignant Neoplasms (SMN) in pediatric oncology patients. The Cancer in Young People – Canada (CYP-C) national pediatric cancer registry was used and reviewed pediatric patients diagnosed with their first cancer from 2000-2015.ResultsA total of 20,272 pediatric patients with a diagnosis of a first malignancy were analyzed. Of them, 0.7% were diagnosed with a SMN within the first 5 years following their first cancer diagnosis. Development of a SMN impacted survival, shown by an inferior survival rate in the SMN cohort (79.1%) after three years compared to that of the non-SMN cohort (89.7%). Several possible risk factors have been identified in the study including the use of epipodophyllotoxins, exposure to radiation, and hematopoietic stem cell 169 transplant.DiscussionThis is the first national study assessing the incidence, 170 characteristics, risk factors and outcome of early SMN in Canadian children 171 from age 0-15 from 2000-2015.
Inhibitory effect of aloperine on transient outward potassium currents in rat cardiac myocytes
Authors: Dong Xiao-Na , Li Meng-Ting 
Published: March 2024

Objective:Aloperine (ALO) is an effective quinolizidine alkaloid. Previous research has demonstrated its antiarrhythmic effect by inhibiting voltage-gated sodium currents in rat ventricular myocytes. This study explored its effect on transient outward potassium currents (Ito) in rat atrial myocytes to identify potential targets in the context of ion channel currents.Methods:The Ito characteristics in rat atrial myocytes were recorded using a whole-cell patch-clamp technique. Molecular docking was performed to validate ligand-protein binding interactions.Results:ALO at concentrations of 3 and 10 μM significantly reduced Ito current densities. Gating kinetics analysis revealed ALO’s ability to slow Ito activation, hasten inactivation, and prolong transition from inactive to resting state. Molecular docking revealed that ALO could stably bind to KCND2.Conclusion:ALO may inhibit Ito by slowing the activation process, accelerating inactivation, and delaying the recovery time after inactivation, potentially preventing acetylcholine-induced AF.
Spraying performance and deposition characteristics of an improved air-assisted nozzle with induction charging
Authors: Zhou Huitao , Ou Mingxiong , Dong Xiang , Zhou Wang , Dai Shiqun , Jia Weidong 
Published: March 2024

Electrostatic spraying technology can improve the efficiency of pesticide deposition on the surface of leaves and reduce the environmental pollution caused by pesticide drift, which has an important prospect in agricultural pesticide application. To improve the deposition and penetration of droplets in the crop canopy, we designed and optimized an air-assisted electrostatic nozzle and conducted the spraying performance experiment. Parameters, such as charge-to-mass ratio (CMR) and particle size, were tested and analyzed to obtain the suitable operating parameters of nozzle. The results proved that the improved air-assisted electrostatic nozzle has good atomization and chargeability. There is a good charging effect with a charging voltage of 3,000–5,000 V, the CMR increased 127.8% from 0.86 to 1.97 mC/kg as the charge voltage increases from 1,000 to 4,000 V, at an air pressure of 1.0 bar and liquid flow rate of 200 ml/min. Furthermore, we designed a multi-factor orthogonal experiment, which was conducted using a four-factor, three-level design to investigate the effects of operational parameters and canopy characteristics on droplet deposition and penetration. Analysis of variance (ANOVA) and F-test were performed on the experiment results. The results showed that the factor effect on droplet penetration, in descending order, was as follows: spray distance, leaf area index, air pressure, and air pressure × spray distance. The factor effect on abaxial leaf deposition, in descending order, was as follows: air pressure, spray distance, air pressure × charge voltage, spray distance × charge voltage, and charge voltage. For optimal droplet penetration and abaxial leaf deposition, option A3B1D2 (air pressure 1.5 bar, spray distance 0.2 m, charge voltage 2,500 V) is recommend. The spray nozzle atomization performance and deposition regulation were studied by experimental methods to determine the optimal values of operating parameters to provide a reference for electrostatic spray system development.
Prevalence of risky sexual behavior and associated factors among Injibara University students, Northwest Ethiopia
Authors: Adal Mekdes Abera , Abiy Saron Abeje , Reta Mebratu Mitiku , Asres Mezgebu Silamsaw , Animut Yaregal 
Published: March 2024

IntroductionEngaging in risky sexual behaviors can lead to HIV infection, sexually transmitted infections, and unintended pregnancy among youths. University students had greater sexual risks for many reasons. Therefore, this study aimed to assess the magnitude and associated factors of risky sexual behaviors among regular undergraduate students at Injibara University, Northwest Ethiopia.MethodsA cross-sectional study was conducted at Injibara University from 20 January to 30 2020. Multistage sampling was employed to select 770 students. Data were collected using a semistructured self-administered questionnaire. A binary logistic regression model was used to identify factors associated with risky sexual behavior. Adjusted odds ratios with 95% CIs were determined, and variables with P-values &lt;0.05 were considered significant.ResultA total of 770 students participated in the study, providing a response rate of 100%. In this study, 294 (38%, 95% CI: 35%, 42%) students engaged in risky sexual behaviors. Risky sexual behavior was significantly associated with not tested for HIV (AOR = 1.62, 95% CI: 1.15–2.31), peer pressure (AOR = 1.90, CI: 1.37–2.64), basic HIV knowledge (AOR = 2.16, CI: 1.65–2.89), substance use (AOR = 3.56, CI: 2.11–6.06), watching pornography videos (AOR = 1.58, CI: 1.11–2.23), and HIV risk perception (AOR = 1.37, CI: 1.02–1.91).Conclusion and recommendationA substantial proportion of university students in this study engaged in unsafe sexual behavior. Risky sexual behaviors are more likely to occur when students are under peer pressure, use substances, have no perceived HIV risk, watch pornography, and have inadequate basic HIV knowledge. Therefore, tailored strategic interventions such as life skill training should be designed to bring about positive behavioral changes among university students.
In vitro aging alters the gene expression and secretome composition of canine adipose-derived mesenchymal stem cells
Authors: Prišlin Marina , Butorac Ana , Bertoša Rea , Kunić Valentina , Ljolje Ivana , Kostešić Petar , Vlahović Dunja , Naletilić Šimun , Turk Nenad , Brnić Dragan 
Published: March 2024

IntroductionCanine adipose-derived mesenchymal stem cells (cAD-MSCs) hold therapeutic promise due to their regenerative potential, particularly within their secretome. However, concerns arise regarding the impact of in vitro cultivation necessitated for storing therapeutic doses, prompting this study to comprehensively explore the impact of in vitro aging on gene expression and secretome composition.MethodsThe study involved collecting abdominal adipose tissue samples from nine healthy female dogs, from which cAD-MSCs were extracted and cultured. Stem cells were validated through trilineage differentiation assays and flow cytometry immunophenotyping. Gene expression profiling using RT-qPCR array, and cAD-MSCs secretome LC-MS/MS analysis, were conducted at passages 3 and 6 to reveal gene expression and protein composition alterations during in vitro culture.Results and DiscussionThe results demonstrate that the gene expression and secretome composition of cAD-MSCs were impacted by in vitro aging. Among many alterations in gene expression between two passages, two significant downregulations were noted in the MSC-associated PTPRC and IL10 genes. While the majority of proteins and their functional characteristics were shared between passages, the influence of cell aging on secretome composition is highlighted by 10% of proteins being distinctively expressed in each passage, along with 21 significant up- and downregulations. The functional attributes of proteins detected in passage 3 demonstrated a greater inclination towards supporting the regenerative capacity of cAD-MSCs. Moreover, proteins in passage 6 exhibited a noteworthy correlation with the blood coagulation pathway, suggesting an elevated likelihood of coagulation events. To the best of our knowledge, this study presents the first original perspective on the changes in secretome composition that occur when cAD-MSCs age in vitro. Furthermore, it contributes to broadening the currently restricted knowledge base concerning the secretome of cAD-MSCs. In conclusion, our findings show that the regenerative potential of cAD-MSCs, as well as their secretome, may be compromised by in vitro aging. Therefore, our study suggests a preference for earlier passages when considering these cells for therapeutic applications.
Intestinal Langerhans cell histiocytosis presenting with symptoms similar to inflammatory bowel disease: a case report
Authors: Liu Yuqing , Chen Zhenwei , Wang Lu , Li Baizhou 
Published: March 2024

Background:Langerhans cell histiocytosis is a rare disease characterized by the abnormal proliferation of Langerhans cells within a single organ or multiple organs. This case report aims to improve the knowledge of the presentation of gastrointestinal Langerhans cell histiocytosis to facilitate the diagnosis and management of this rare disorder.Case presentation:A 19-month-old female presented with repeatedly mucinous bloody stools. The abdominal ultrasound revealed a slightly enlarged spleen. The initial colonoscopy revealed chronic enteritis with a very early onset inflammatory bowel disease. After anti-inflammatory treatment without improvement, an intestinal biopsy was performed at The Forth Affiliated Hospital of Zhejiang University. The final intestinal biopsy and histopathology examination confirmed the presence of Langerhans cell histiocytosis. After diagnosis, additional lung and head imaging examinations revealed no abnormalities. Her condition improved gradually after being treated with chemotherapy (vincristine and prednisone) and molecular-targeted drug(dalafinil) treatment.Conclusion:The clinical symptoms of Langerhans cell histiocytosis involving the gastrointestinal tract are not specific and may resemble symptoms observed in inflammatory bowel disease and other primary gastrointestinal tumors. Therefore, in cases of infants presenting with inflammatory gastrointestinal symptoms that do not resolve after treatment, a biopsy is essential to obtain a differential diagnosis.
HUBUNGAN VAKSINASI COVID-19 DENGAN TINGKAT KECEMASAN PADA LANSIA PASCA VAKSINASI DI PANTISOSIAL BUDI AGUNG KOTA KUPANG
Authors: Jahang Yohanes Christofel , Sasputra I Nyoman , Woda Rahel Rara 
Published: March 2024

Prevalensi dan angka kematian selama pandemic corona virus disease 2019 (COVID-19) secara global maupun nasional semakin meningkat setiapharinya sehingga dilakukan berbagai intervensi untuk memutus penyebaran COVID-19 yang salah satunya adalah vaksinasi. Indonesia sendiri membagi bebera pake lompok penerima vaksinasi yang dilihat berdasarkan risiko tinggi terinfeksi COVID-19 salah satunya adalah kelompok lanjut usia (lansia). Berdasarkan hasil survey penerimaan vaksin bahwa terdapat 7,6% masyarakat menolak vaksin karena cemas dengan keamanan dan efektifitas dari vaksin ditambah lagi dengan adanya mutasi dari corona virus. Penelitian ini bertujuan untuk mengetahui apakah ada hubungan vaksinasi COVID-19 dengan tingkat kecemasan pada lansia pasca vaksinasi di Panti Sosial Budi Agung Kota Kupang. Penelitian ini menggunakan desain penelitian observasional analitik dengan rancangan cross sectional. Pengambilan sampel menggunakan teknik purposive sampling dan didapatkan 53 subjek penelitian. Dari hasil uji menggunakan uji chi-square, tidak terdapat hubungan antara vaksinasi COVID-19 dengan tingkat kecemasan lansia pasca vaksinasi dengan nilai p=0,071. Kesimpulan penelitian ini tidak terdapat hubungan antara vaksinasi COVID-19 dengantingkatkecemasanlansiapascavaksinasi di PantiSosial Budi Agung Kota Kupang.
HUBUNGAN TINGKAT STRES DENGAN KEJADIAN SINDROM DISPEPSIA PADA MAHASISWA PENDIDIKAN PROFESI DOKTER FAKULTAS KEDOKTERAN UNIVERSITAS NUSA CENDANA KUPANG
Authors: Natu Deny Leonardo , Artawan I Made , Trisno Idawati 
Published: March 2024

Dispepsia merupakan kumpulan gejala atau sindrom yang terdiri dari nyeri atau rasa tidak nyaman di bagian epigastrium, mual, muntah, kembung, cepat kenyang, rasa perut penuh, sendawa, regurgitasi, serta rasa panas yang menjalar di bagian dada. Salah satu faktor pencetus yang berhubungan dengan prevalensi kejadian dispepsia tersebut adalah faktor psikologis yaitu seperti stres, dimana saat stres terjadi maka tubuh akan merespon dengan disekresinya hormone kortisol. Tujuan penelitian untuk mengetahui hubungan antara tingkat stres dengan kejadian sindrom dispepsia pada mahasiswa Pendidikan Profesi Dokter Fakultas Kedokteran Universitas Nusa Cendana Kupang. Metode penelitian ini merupakan penelitian analitik observasional dengan pendekatan cross sectional. Teknik pengambilan sampel adalah stratified random sampling. Data diperoleh dari pengisian kuesioner DASS 42 dan PADYQ oleh 54 reponden mahasiswa Pendidikan Profesi Dokter Fakultas Kedokteran Universitas Nusa Cendana Kupang yang memenuhi kriteria. Hasil analisis bivariat dilakukan dengan menggunakan uji statistik spearman’s rank correlation.Hasil penelitian dari data 54 responden menunjukan 34 responden (63,0%) mengalami stres dan 20 responden (37,0%) lainnya tidak mengalami stres (normal) dan untuk sindrom dispepsia data menunjukan 37 responden (68,5%) mengalami sindrom dispepsia dan 17 responden (31,5%) lainnya tidak mengalami sindrom dispepsia (normal). hasil uji statistik bivariat diperoleh hasil bahwa nilai p=0,03 yang menunjukan terdapat hubungan antara stres dan sindrom dispepsia pada mahasiswa Pendidikan Profesi Dokter Fakultas Kedokteran Universitas Nusa Cendana Kupang. Kesimpulan penelitian terdapat hubungan yang signifikan antara tingkat stres dengan kejadian sindrom dispepsia pada mahasiswa Pendidikan Profesi Dokter Fakultas Kedokteran Universitas Nusa Cendana Kupang yang menunjukan bahwa semakin tinggi mahasiswa mengalami stres maka semakin rentan mahasiswa mengalami sindrom dispepsia.
HUBUNGAN TINGKAT DEPRESI DENGAN KUALITAS HIDUP PERAWAT RSUD PROF. DR. W Z JOHANNES DI ERA PANDEMI COVID-19
Authors: Matulessy Giovanni Kathlix immanuel , Buntoro Ika Febianti , Etty Dedy Maria Agnes 
Published: March 2024

Latar Belakang : The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) telah meyebabkan wabah Coronavirus Disease (COVID19) yang mempegaruhi berbagai bidang di dunia, salah satunya bidang kesehatan. Perawat merupakan salah satu kelompok tenaga kesehatan yang memiliki proporsi jumlah terbesar dengan tingkat intesitas kerja yang tinggi di rumah sakit. Tingkat intensitas kerja yang tinggi, kesulitan menjalin hubungan dengan anggota keluarga, kesulitan dalam merawat pasien kritis, risiko terkena infeksi, dan faktor lainnya dapat menyebabkan ganguan psikologis seperti depresi bagi para perawat. Depresi pada perawat akan berdampak pada perubahan emosional, kognitif, motivasi, perasaan cemas, gelisah, perasaan terpuruk yang dapat menurunkan efektifitas kerja dan dapat mempegaruhi kualitas hidup perawat itu sendiri. Kualitas Hidup yang buruk memiliki peranan penting untuk kesejahteraan dalam menjalani kehidupan dan akan berpegaruh pada masalah kesehatan sesorang yang mungkin timbul di kemudian hari.
Tujuan: Mengetahui hubungan antara tingkat depresi dengan tingkat kualitas hidup perawat pada era pandemi COVID-19 di RSUD Prof. Dr. W. Z. Johannes Kupang.
Metode : Penelitian ini merupakan penelitian analitikal observasional dengan rancangan cross sectional yang dilakukan pada perawat ruangan NICU,ICU dan komodo di RSUD Prof. Dr. W. Z. Johannes Kupang,dengan cara pengisian kuesioner Beck Depression Inventory II (BDI-II). dan kuisioner The World Health Organisasion Quaity Of Life (WHOQOL) –BREF. Teknik pengambilan sampel menggunakan Total sampling dengan jumlah responden 44 orang yang memenuhi kriteria inklusi dan eksklusi. Penelitian dianalisis secara univariat, bivariat menggunakan uji chi-square.
Hasil: Dari 44 responden, didapatkan hasil 29 responden (65,9%) tidak memiliki depresi, 12 responden (27,27%) memiliki tingkat depresi ringan dan 3 responden (6,8%) memiliki tingkat depresi sedang. Dari 44 responden juga didapatkan 30 responden (68,18%) memiliki kualitas hidup buruk dan 14 responden (31,18%) memiliki kualitas hidup baik. Hasil uji analisis bivariat pada penelitiaan ini diperoleh hasil p=0,035 (p<0,05).
Kesimpulan : Terdapat hubungan yang signifikan antara tingkat depresi dengan tingkat kualitas hidup perawat pada era pandemi COVID-19 di RSUD Prof. Dr. W. Z. Johannes Kupang.
TINJAUAN GEOGRAFIS DAMPAK PENGEMBANGAN EKOWISATA TERHADAP LINGKUNGAN HUTAN LINDUNG OELUAN DI DESA BIJELI KABUPATEN TIMOR TENGAH UTARA
Authors: Sanam Maria V. I. , Samin Mikael , Pamungkas Bella Theo Tomi 
Published: March 2024

One of the tourism in Bijeli Village is the Oeluan Forest tourist area. The objectives of this study to: (1) describe the physical condition of the ecotourism development of the Oeluan Forest in the research area, (2) describe the impact of ecotourism development on the environment of the Oeluan Protected Forest in the research area, ; (3) describe the government's way of dealing with the degradation of the Oeluan Forest. The type of this research is descriptive qualitative with 20 informants, selected by purposive sampling. Sources of data in the form of primary data and secondary data. Data collection methods: interviews, observations, documentation studies. Qualitative descriptive data analysis. The results of the study are as follows: (1) the development of tourism in the Oeluan Forest Area in Bijeli Village continues to increase the tourism facilities and infrastructure such as villa accommodation and other supporting facilities and infrastructure. However, with this development there are several buildings that are not considered. (2) tourism development has an impact on the environment both on the community environment and the environment of the Oeluan Forest. The impact are lack of availability of clean water and damage to vegetation due to illegal logging and neglected development which can damage the Oeluan Forest and also scattered garbage. (3) the government needs to overcome forest degradation by reforestation and prohibiting people from carrying out forest degradation and cooperate with the Bijeli community to carry out mutual cooperation.
ANALYSIS OF CHATBOOT APPLICATIONS IN SERVICES OUTPUT TREATMENT WITH THE TAM MODEL APPROACH
Authors: Saputera Surya Ade , Afrika Sari Yuyun 
Published: March 2024

Dalam pelayanan berobat jalan, terdapat keterbatasan sumber daya seperti tenaga medis, waktu tunggu, dan ruang fisik yang terbatas. Menggunakan aplikasi chatbot dapat membantu mengatasi keterbatasan dengan memberikan akses yang lebih cepat dan efisien bagi pasien untuk mendapatkan informasi dan konsultasi medis. Tujuan dari penelitian ini yakni untuk menganalisis persepsi pengguna terhadap penggunaan aplikasi chatbot dalam pelayanan berobat jalan menggunakan TAM Model. Metode penelitian dalam penelitian ini adalah metode survey, Populasi dalam penelitian ini adalah pasien yang melakukan rawat jalan. Metode analisis yang digunakan yaitu analisis regresi linier berganda, Uji –T dan Uji-F. Hasil penelitian Variabel Perceived Usefulness tidak berpengaruh terhadap Attitude Towards Using pengguna dalam penggunaan aplikasi chatboot dalam pelayanan berobat jalan dengan tingkat signifikansi 0,324 > α (0,05). Perceived Ease of Use berpengaruh terhadap Attitude Towards Using pengguna dalam penggunaan aplikasi chatboot dalam pelayanan berobat jalan dengan tingkat signifikansi 0,001 < α (0,05). Perceived Usefulness dan Perceived Ease of Use secara bersama-sama berpengaruh terhadap Attitude Towards Using pengguna dalam penggunaan aplikasi chatboot dalam pelayanan berobat jalan.
Kata Kunci : Perceived Usefulness, Perceived Ease of Use, Attitude Towards Using, Chatbot, TAM Model
Effectiveness Of E-Backnshou Exercise To The Improvement Of Neck, Shoulder And Back Pain In Computer Vision Syndrome Patient
Authors: Julianti Hari Peni , Nugroho Trilaksana , Kesoema Tanti Ajoe , Susilaningsih Neni , Rahmi Fifin Luthfia , Pritadesya Maharani Prizka 
Published: March 2024

BACKGROUND : Extra-ocular complaints of Computer Vision Syndrome (CVS) are neck, shoulder, back pain. The 20-20-20 rule and E-BACKNSHOU exercise are expected to improve accommodative mechanisms, ocular surface of the eye and extra ocular symptoms of CVS.
AIMS : Proving the effectiveness of E-BACKNSHOU exercise for the improvement of neck, shoulder and back pain in CVS patient.
METHOD : The research design was Pre-Post Test with Control Design. Subjects were 30 medical students of Faculty of Medicine, Diponegoro University, Semarang, Indonesia who experienced CVS and neck, shoulder and back pain. The treatment group got the 20-20-20 rule and E-BACKNSHOU exercise and the control group got the 20-20-20 rule for 1 month. Pain was measured by Visual Analogue Scale (VAS). Statistical test was conducted using paired t-test, unpaired t-test and chi square. Value of significance p<0.05.
RESULT : There were significant differences in VAS score of neck, shoulder, upper back pain (p=0.00), and low back pain (p=0.022) before and after the intervention in the treatment group and VAS score of neck (p=0,002), shoulder (p=0.020), upper back (p=0.011), and low back pain (p=0.019) in the control group. Delta VAS score of the treatment group was greater than the control group and there was a significant difference in delta VAS score of shoulder pain (p=0,030), but there were no significant differences in delta VAS score of neck (p=0,934), upper back (p=0,356), and low back pain (p=0,150).
CONCLUSION : The effectiveness of 20-20-20 rule and E-BACKNSHOU exercise is better than the 20-20-20 rule alone on treating neck, shoulder and back pain in CVS patient.