bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative analysis of videofluoroscopy and pulse oximetry for aspiration identification in patients with dysphagia after stroke and non-dysphagics
Authors: Bengisu Serkan , Öge-Daşdöğen Özlem , Yıldız Hatice Yelda 
Published: April 2024

Abstract
Purpose
Dysphagia is a prevalent symptom observed in acute stroke. Several bedside screening tests are employed for the early detection of dysphagia. Pulse oximetry emerges as a practical and supportive method to augment the existing techniques utilized during bedside swallowing assessments. Desaturation levels, as measured by pulse oximetry, are acknowledged as indicative of aspiration by certain screening tests. However, the predictive capability of pulse oximetry in determining aspiration remains a subject of controversy. The objective of this study was to compare aspiration and oxygen desaturation levels by time and aspiration severity in dysphagic patients compared to healthy controls. It also aimed to evaluate the accuracy of pulse oximetry by comparing it with VFSS findings in detecting aspiration in both liquid (IDDSI-0) and semi-solid (IDDSI-4) consistencies.

Materials and methods
Eighty subjects (40 healthy and 40 acute stroke patients) participated. Patients suspected of dysphagia underwent videofluoroscopy as part of the stroke unit’s routine procedure. Baseline SpO2 was measured before VFSS, and stabilized values were recorded. Sequential IDDSI-0 and IDDSI-4 barium tests were conducted with 5 ml boluses. Stabilized SPO2 values were recorded during swallowing and 3-min post-feeding. Patients with non-dysphagia received equal bolus monitoring. Changes in SPO2 during, before, and after swallowing were analyzed for each consistency in both groups.

Results
The study revealed a statistically significant difference in SPO2 between patients with dysphagia and controls for IDDSI-4 and IDSSI-0. In IDDSI-4, 20% of patients experienced SpO2 decrease compared to 2.5% in control group (p = 0.013). For IDDSI-0, 35% of patients showed SpO2 decrease, while none in the control group did (p = 0.0001). Aspiration rates were 2.5% in IDDSI-4 and 57.5% in IDDSI-0. In IDDSI-0, SpO2 decrease significantly correlated with aspiration (p = 0.0001). In IDDSI-4, 20.5% had SpO2 decrease without aspiration, and showing no significant difference (p = 0.613). Penetration-Aspiration Scale scores had no significant association with SpO2 decrease (p = 0.602). Pulse oximetry in IDDSI-4 had limited sensitivity (0%) and positive predictive value, (0%) while in IDDSI-0, it demonstrated acceptable sensitivity (60.9%) and specificity (100%) with good discrimination capability (AUC = 0.83).

Conclusions
A decrease in SPO2 may indicate potential aspiration but is insufficient alone for detection. This study proposes pulse oximetry as a valuable complementary tool in assessing dysphagia but emphasizes that aspiration cannot be reliably predicted based solely on SpO2 decrease.
Piezo1, the new actor in cell volume regulation
Authors: Michelucci A. , Catacuzzeno L. 
Published: April 2024

AbstractAll animal cells control their volume through a complex set of mechanisms, both to counteract osmotic perturbations of the environment and to enable numerous vital biological processes, such as proliferation, apoptosis, and migration. The ability of cells to adjust their volume depends on the activity of ion channels and transporters which, by moving K+, Na+, and Cl− ions across the plasma membrane, generate the osmotic gradient that drives water in and out of the cell. In 2010, Patapoutian’s group identified a small family of evolutionarily conserved, Ca2+-permeable mechanosensitive channels, Piezo1 and Piezo2, as essential components of the mechanically activated current that mediates mechanotransduction in vertebrates. Piezo1 is expressed in several tissues and its opening is promoted by a wide range of mechanical stimuli, including membrane stretch/deformation and osmotic stress. Piezo1-mediated Ca2+ influx is used by the cell to convert mechanical forces into cytosolic Ca2+ signals that control diverse cellular functions such as migration and cell death, both dependent on changes in cell volume and shape. The crucial role of Piezo1 in the regulation of cell volume was first demonstrated in erythrocytes, which need to reduce their volume to pass through narrow capillaries. In HEK293 cells, increased expression of Piezo1 was found to enhance the regulatory volume decrease (RVD), the process whereby the cell re-establishes its original volume after osmotic shock-induced swelling, and it does so through Ca2+-dependent modulation of the volume-regulated anion channels. More recently we reported that Piezo1 controls the RVD in glioblastoma cells via the modulation of Ca2+-activated K+ channels. To date, however, the mechanisms through which this mechanosensitive channel controls cell volume and maintains its homeostasis have been poorly investigated and are still far from being understood. The present review aims to provide a broad overview of the literature discussing the recent advances on this topic.
Total face mask with neurally adjusted ventilatory assist as a rescue therapy in infants with severe bronchiolitis
Authors: Cousin Vladimir L. , Corbisier Tiphaine , Rimensberger Peter C. , Polito Angelo , Bordessoule Alice 
Published: April 2024

Abstract
Severe bronchiolitis patients are often supported with non-invasive ventilation (NIV). In case of NIV failure, we recently started to use non-invasive neurally adjusted ventilatory assist ventilation (NIV-NAVA) with a total face mask interface (TFM) and report now our experience with this modality of respiratory support. Retrospective study was made from October 2022 to May 2023 at the Geneva University Hospital Paediatric Intensive Care Unit. Inclusion criteria were children, aged from 0 to 6 months, with severe bronchiolitis with initial NIV failure and switch to NIV-NAVA-TFM. From 49 children with respiratory syncytial virus (RSV)-induced bronchiolitis requiring any form of respiratory support, 10 (median age 61 days (IQR 44–73) failing CPAP or NIV underwent rescue treatment with NIV-NAVA using a TFM. Patients were switched to TFM-NIV-NAVA 8 h (IQR 3–22) after admission for 24.5 h (IQR 13–60). After initiation of TFM-NIV-NAVA, oxygenation improved significantly as early as 1 h after initiation, whereas transcutaneous CO2 values remained stable. None of the patients needed to be intubated and there was no episode of TFM discontinuation due to interface discomfort or other unwanted side effects. Sedation was used in all patients with high proportion of intravenous dexmedetomidine. Median ventilatory assistance duration was 2.5 days (IQR 2–4) and median PICU stay was 4.5 (IQR 3–6).
Conclusion: In infants with severe RSV-induced bronchiolitis, respiratory support with TFM-NIV-NAVA seems to be feasible as a rescue therapy and might be considered in selected patients.

What is Known:• Bronchiolitic patients with NIV support failure may require invasive mechanical ventilation.• Interface related complications, especially facial sores, can be a cause of NIV failure.

What is New:• Total face mask with non-invasive neurally adjusted ventilatory assist (TFM-NIV-NAVA) seems feasible as a rescue therapy in deteriorating patients with CPAP or NIV failure.• TFM-NIV-NAVA can improve oxygenation rapidly in patients with aggravating hypoxemia and seems to be well tolerated.
Boundary controllability for a 1D degenerate parabolic equation with a Robin boundary condition
Authors: Galo-Mendoza Leandro , López-García Marcos 
Published: April 2024

AbstractIn this paper, we prove the null controllability of a one-dimensional degenerate parabolic equation with a weighted Robin boundary condition at the left endpoint, where the potential has a singularity. We use some results from the singular Sturm–Liouville theory to show the well-posedness of our system. We obtain a spectral decomposition of a degenerate parabolic operator with Robin conditions at the endpoints, we use Fourier–Dini expansions and the moment method introduced by Fattorini and Russell to prove the null controllability and to obtain an upper estimate of the cost of controllability. We also get a lower estimate of the cost of controllability by using a representation theorem for analytic functions of exponential type.
Exploring contactless techniques in multimodal emotion recognition: insights into diverse applications, challenges, solutions, and prospects
Authors: Khan Umair Ali , Xu Qianru , Liu Yang , Lagstedt Altti , Alamäki Ari , Kauttonen Janne 
Published: April 2024

AbstractIn recent years, emotion recognition has received significant attention, presenting a plethora of opportunities for application in diverse fields such as human–computer interaction, psychology, and neuroscience, to name a few. Although unimodal emotion recognition methods offer certain benefits, they have limited ability to encompass the full spectrum of human emotional expression. In contrast, Multimodal Emotion Recognition (MER) delivers a more holistic and detailed insight into an individual's emotional state. However, existing multimodal data collection approaches utilizing contact-based devices hinder the effective deployment of this technology. We address this issue by examining the potential of contactless data collection techniques for MER. In our tertiary review study, we highlight the unaddressed gaps in the existing body of literature on MER. Through our rigorous analysis of MER studies, we identify the modalities, specific cues, open datasets with contactless cues, and unique modality combinations. This further leads us to the formulation of a comparative schema for mapping the MER requirements of a given scenario to a specific modality combination. Subsequently, we discuss the implementation of Contactless Multimodal Emotion Recognition (CMER) systems in diverse use cases with the help of the comparative schema which serves as an evaluation blueprint. Furthermore, this paper also explores ethical and privacy considerations concerning the employment of contactless MER and proposes the key principles for addressing ethical and privacy concerns. The paper further investigates the current challenges and future prospects in the field, offering recommendations for future research and development in CMER. Our study serves as a resource for researchers and practitioners in the field of emotion recognition, as well as those intrigued by the broader outcomes of this rapidly progressing technology.
Usefulness of double plate fixation after failed ORIF for clavicle shaft fracture
Authors: Woo Seung Hun , Bae Jung Yun , Jung Sung Won , Choi Min-Hyeok , Kang Suk-Woong 
Published: April 2024

Abstract
Purpose
We aimed to evaluate the clinical and radiological outcomes of double plate fixation for failed clavicle shaft fracture surgery.

Materials and methods
We analyzed 14 patients who underwent double plate fixation due to plate failure after clavicle shaft fracture surgery from March 2016 to March 2021. The study used 3.5 mm locking compression plates for superior clavicle and anterior reconstruction in all patients. In addition, moldable allograft bone was used to fill the bone defect. Clinical and radiological evaluation was performed immediately, at 2 and 4 weeks, and 3, 6, 9, and 12 months postoperatively. The visual analog scale (VAS), University of California at Los Angeles (UCLA) shoulder scale, and American Shoulder and Elbow Surgeons (ASES) scores and range of motion of the shoulder were evaluated as clinical results. For radiological evaluation, anteroposterior, caudal, and cephalad views of both clavicles were used. Successful bone union was defined as complete adjoining of the fracture site through callus formation.

Results
Successful bone union was achieved in all patients, and the mean time to bone union was 16.7 ± 1.2 weeks (range, 12–24 weeks).
Statistically significant improvement in forward flexion and external and internal rotation was observed from 135.5° ± 6.3, 45.2° ± 5.3, and 13° ± 2.3 preoperatively to 157.0° ± 9.3, 68.7° ± 6.3, and 9.8° ± 3.1 at the final follow-up, respectively.
The VAS score improved from an average of 6.2 ± 2.8 preoperatively to 1.3 ± 0.7 at the final follow-up, which was statistically significant (P = 0.018). In addition, the ASES score significantly increased from a mean of 52.1 ± 6.3 points preoperatively to 83.6 ± 7.8 points at the final follow-up (P = 0.001).
The average UCLA shoulder score was 16.7 ± 1.4 and 31.4 ± 2.2 points preoperatively and at the final follow-up, respectively, which was statistically significant (P = 0.001).

Conclusion
Double plate fixation has shown good results after failed open reduction and internal fixation (ORIF) for clavicle shaft fractures. Therefore, in complicated situations after ORIF, double plate fixation is considered a surgical treatment option.
Opting Out as an Untapped Resource in Instructional Design: Review and Implications
Authors: Sidi Yael , Ackerman Rakefet 
Published: April 2024

AbstractWhen faced with challenging thinking tasks accompanied by a feeling of uncertainty, people often prefer to opt out (e.g., replying “I don’t know”, seeking advice) over giving low-confidence responses. In professions with high-stakes decisions (e.g., judges, medical practitioners), opting out is generally seen as preferable to making unreliable decisions. Contrarily, in educational settings, despite being designed to prepare students for real-life challenges, opting out is often viewed as an indication of low motivation or an avoidance of challenges. Presenting a complementary perspective, metacognitive research dealing with knowledge management and problem-solving shows substantial empirical evidence that both adults and children can use opt-out options to enhance the quality of their responses. Moreover, there are initial signs that strategic opting out can increase the efficiency of self-regulated effort. These opportunities to improve self-regulated learning have yet to be exploited in instructional design. Research guided by Cognitive Load Theory (CLT), which focuses on effort allocation in the face of cognitive challenges, has largely ignored the benefits of opting out as a strategy for improving effort allocation. The present review summarizes advantages and pitfalls within the current state of knowledge. Furthermore, we propose new avenues of inquiry for examining the impact of incorporating explicit opt-out options in instructional design to support knowledge and skill acquisition. As a novel avenue, we urge educators to develop effective opting-out skills in students to prepare them for real-life challenges.
A Note on the Binding Energy for Bosons in the Mean-Field Limit
Authors: Boßmann Lea , Leopold Nikolai , Mitrouskas David , Petrat Sören 
Published: April 2024

AbstractWe consider a gas of N weakly interacting bosons in the ground state. Such gases exhibit Bose–Einstein condensation. The binding energy is defined as the energy it takes to remove one particle from the gas. In this article, we prove an asymptotic expansion for the binding energy, and compute the first orders explicitly for the homogeneous gas. Our result addresses in particular a conjecture by Nam (Lett Math Phys 108(1):141–159, 2018), and provides an asymptotic expansion of the ionization energy of bosonic atoms.
Certain analytical solutions of the concatenation model with a multiplicative white noise in optical fibers
Authors: Ekici Mehmet , Sarmaşık Cansu Ali 
Published: April 2024

AbstractIn the presence of spatio-temporal dispersion, perturbation terms of the Hamiltonian type as well as multiplicative white noise, analytical investigation of the concatenation model having the Kerr law of nonlinearity is carried out in this work. The Cole–Hopf transformation and direct assumptions with arbitrary functions are utilized to determine several analytic solutions to the governing equation, including multi-wave, two solitary wave, breather, periodic cross kink, Peregrine-like rational, and three-wave solutions. The parameter constraints that serve as the requisite condition for the existence of these wave solutions are also identified. In order to explore and illustrate the propagation and dynamical behaviors of some solutions reported in this research, 3D graphics and their corresponding contour plots are included. Results of this paper may be useful for the experimental realization of certain nonlinear waves in optical fibers and further understanding of their propagation dynamics.
2500 years ago scientific theories of the origin of life arose in ancient Greece
Authors: Cartwright Julyan H. E. 
Published: April 2024

AbstractWhat have the Greeks ever done for us? Everything. This short commentary celebrating the earliest history of origin of life research seeks to bring to the attention of the community of origin of life researchers that there is a much longer tradition of scientific theories in this subject than some people are aware of; there are 2500 years of thinking that we should not forget about. In Ionian Greece, Thales initiated ideas that we can see as the beginnings of science itself. Anaximander, his pupil, was particularly interested in the origins of the world, including how life had arisen, and proposed a species of proto-evolutionary theory of the origin of life. 2500 years ago, Anaxagoras left Ionia for Athens taking ideas of scientific thinking with him. Anaxagoras is credited with being the originator of a further theory of the origin of life, that of panspermia. The scientific conception of knowledge was attacked almost immediately, and Anaxagoras ended up exiled, but that idea of the knowability of things survived and led, many centuries later, to the scientific revolution and to our current human civilization.
Synergistic effects of L-glutamine and inorganic nitrogen molar ratios enhance the induction of somatic embryogenesis of Pinus maximinoi H.E. Moore
Authors: Nzama P. S. , Myburg A. A. , Hills P. N. 
Published: April 2024

AbstractClonal breeding programs of Pinus maximinoi require the establishment of a robust somatic embryogenesis (SE) protocol to produce enough cell lines to accelerate the effective continuous deployment of elite planting stocks to research and commercial compartments. Somatic embryogenesis was induced from immature zygotic embryo explants enclosed in megagametophytes of P. maximinoi collected from two plantations located in different climatic conditions. Cones were collected during the winter months from July to August and the influence of seed family, cone collection date and culture medium formulation, with emphasis on the organic and inorganic nitrogen supply, were studied. Ammonium to nitrate molar ratios of 1:1 and 1:2 in modified Litvay’s medium (mLV) produced the highest numbers of extrusions, while a 1:4 ratio mostly produced unhealthy, non-embryogenic extrusions. The formation of a tissue showing a rapidly-proliferating, spiky morphotype was produced in a medium supplemented with 1.5 g/L of L-glutamine. Morphologically advanced cultures with nodular structures were produced in megagametophytes from both plantations in a 1:2 NH4+:NO3− medium regardless of L-glutamine supplementation levels. The optimal medium for P. maximinoi SE induction contained a 1:2 NH4+:NO3− molar ratio with 1.5 g/L L-glutamine. The synergy between the molar ratio of NH4+:NO3− and L-glutamine resulted in the highest numbers of extrusions. The overall inductive competence window for somatic embryogenic response in P. maximinoi was determined to be from the second week of July to the first week of August for both plantations. The “peak” period was in the fourth week of July 2022. The success of the SE technology in P. maximinoi seed families is determined by the optimal inductive competence window of the immature megagametophytes enclosing zygotic embryos and the chemical composition of the induction medium in terms of the ammonium to nitrate molar ratio and the concentration of the L-glutamine used.
Magneto-Permeability Effect in Ferrofluid Flow Through Porous Media Studied via Multiparticle Collision Dynamics
Authors: Ilg Patrick 
Published: April 2024

AbstractAs more and more promising applications of magnetic nanoparticles in complicated environments are explored, their flow properties in porous media are of increasing interest. We here propose a hybrid approach based on the multiparticle collision dynamics method extended to porous media via friction forces and coupled with Brownian dynamics simulations of the rotational motion of magnetic nanoparticles’ magnetic moment. We simulate flow in planar channels homogeneously filled with a porous medium and verify our implementation by reproducing the analytical velocity profile of the Darcy–Brinkman model in the non-magnetic case. In the presence of an externally applied magnetic field, the non-equilibrium magnetization and friction forces lead to field-dependent velocity profiles that result in effective, field-dependent permeabilities. We provide a theoretical expression for this magneto-permeability effect in analogy with the magneto-viscous effect. Finally, we study the flow through planar channels, where only the walls are covered with a porous medium. We find a smooth crossover from the Poiseuille profile in the center of the channel to Brinkman–Darcy flow in the porous layers. We propose a simple estimate of the thickness of the porous layer based on the flow rate and maximum flow velocity.
Two-character sets, Veronese varieties and Grassmannian of lines
Authors: Cossidente A. , Marino G. 
Published: April 2024

AbstractWe show that, for any q, the pointset covered by the conic planes of a quadric Veronesean of $$\textrm{PG}(3,q)$$

PG
(
3
,
q
)

is a two character set with respect to hyperplanes of $$\textrm{PG}(9,q)$$

PG
(
9
,
q
)

.
Volume changes of diseased and normal areas in progressive fibrosing interstitial lung disease on inspiratory and expiratory computed tomography
Authors: Kobayashi Taiga , Kunihiro Yoshie , Uehara Takuya , Tanabe Masahiro , Ito Katsuyoshi 
Published: April 2024

Abstract
Purpose
The diagnosis of progressive fibrosing interstitial lung disease (PF-ILD) using computed tomography (CT) is an important medical practice in respiratory care, and most imaging findings for this disease have been obtained with inspiratory CT. It is possible that some characteristic changes in respiration may be seen in normal and diseased lung in PF-ILD, which may lead to a new understanding of the pathogenesis of interstitial pneumonia, but it has never been examined. In this study, we collected and selected inspiratory and expiratory CT scans performed in pure PF-ILD cases, and evaluated the volumes of diseased and normal lung separately by manual detection and 3-dimensional volumetry to characterize the dynamic features of PF-ILD.

Materials and methods
Cases were collected retrospectively from a total of 753 inspiratory and expiratory CT scans performed at our hospital over a 3-year period. Sixteen cases of pure PF-ILD, excluding almost all other diseases, were included. We measured their diseased, normal, and the whole lung volumes manually and evaluated the correlation of their values and their relationship with respiratory function tests (FVC, FVC%-predicted, and DLCO%-predicted).

Results
The relative expansion rate of the diseased lung is no less than that of the normal lung. The “Expansion volume of total lung” divided by the “Expansion volume of normal lung” was found to be significantly associated with DLCO%-predicted abnormalities (p = 0.0073).

Conclusion
The diseased lung in PF-ILD retained expansion capacity comparable to the normal lung, suggesting a negative impact on respiratory function.