bluuebunny/crossref_metadata_2025_split huggingface dataset:
Presence of a carcinoma‐associated antigen(s) in the spent chemically defined medium of a human colon carcinoma cell line
Authors: Chee Darwin O. , Gupta Rishab K. , Morton Donald L. 
Published: February 2007

AbstractThe human colon carcinoma cell line HT‐29 was adapted to grow in chemically defined medium (CDM). The spent CDM (S‐CDM) was concentrated by Amicon filtration and the crude HT‐29 S‐CDM purified by 40% saturated(NH4)2 SO4 precipitation. The purified antigen was tested by a micro‐complement fixation (MCF) assay against the sera of cancer patients of various histologic types and against the sera of normal donors. Fifteen of 20 (75%) colon cancer, 16/20 (80%) breast cancer sera, 14/19 (74%) lung cancer sera, and 13/20 (65%) miscellaneous carcinoma sera were positive in the MCF. By contrast, 2/21 (10%) melanoma sera, 7/20 (35%) sarcoma sera, and 2/19 (11 %) normal sera were positive. These data suggest the presence of a carcinoma‐associated antigen in the spent CDM of the HT‐29 colon carcinoma cell line adapted to grow in CDM.
Rehabilitation of patients after repeated operations for cancer of colon and rectum
Authors: Simonov Nicholas N. , Mosidze Badur A. 
Published: February 2007

AbstractThe authors investigated social and occupational rehabilitation of patients treated at N.N. Petrov Research Institute of Oncology for cancer recurrences in colon and rectum (96 cases), for metachronic neoplasms (40 cases), and also for patients accepted for coloplasty after Hartmann operation (11 cases). The term of hospitalization in cancer recurrences was 15.9 ± 2.5 months; in metachronic tumors, 77.1 ± 9.9 months; and for the patients accepted for coloplasty, from 6 to 12 months. The period of patients' survival after radical operations in cases of metachronic tumors is twice as long as in recurrences and approaches, on the average, five years. The patients operated upon for their metachronic tumors are characterized by a high degree of social and occupational readaptation (about 80%) in comparison with patients with tumor recurrences (30%). All the patients who had undergone coloplasty were subsequently completely readapted from a social point of view, which was due to the elimination of a fecal fistula.
A method for temporary reconstitution of the cervical esophagus
Authors: Cochran John H. , Shinn John B. 
Published: February 2007

AbstractA simple method of temporary reconstitution of the cervical esophagus in major head and neck surgery is detailed in a case report. Accompanying diagrams illustrate the mechanics of inserting a number 26 nasopharyngeal airway from the hypopharynx to the esophagus. This arrangement simplifies the management of oral secretions until permanent reconstruction of the cervical esophagus can be accomplished.
An investigation of the cause of death from cancer
Authors: Houten Lorne , Reilley Andrew A. 
Published: February 2007

AbstractFour thousand seven hundred twenty‐eight autopsies performed at the Roswell Park Memorial Institute were reviewed to determine causes of death from cancer. The duration of the disease from the date of diagnosis to death, the primary site of the tumor, a detailed description of the presence or absence of metastatic tumor at a series of sites, and an estimate of the total tumor mass were included in the evaluation. Twenty‐three common primary sites were selected for investigation. These sites represented 99% of the total series. Nine causes of death were described. These were respiratory failure, infection, toxic drug reaction, hepatic failure, renal failure, shock or heart failure, adrenal gland failure, electrolyte imbalance, and central nervous system failure. Some of these associations were obviously due to the direct destruction of the organ in question. There are some differences, however, comparing lung lesions to hepatic lesions. These and other factors are recited in the text.
“High‐affinity” t‐cell rosettes: The effects of clinical manipulations and potential prognostic significance
Authors: Weese James L. , West William H. , Herberman Ronald B. , Payne Susan M. , Siwarski Joyce W. , Turcotte Jeremiah G. 
Published: February 2007

AbstractIncubation of blood mononuclear cells with sheep erythrocytes at 29°C identifies “high‐affinity” rosette‐forming T‐cells (RFC). The proportion of highaffinity RFC was more frequently depressed in patients with cancer than the total number of RFC identified under optimal rosetting conditions. Our purpose was to determine the effect of chemotherapy and/or immunotherapy on the level of RFC and to determine whether trends in serial values had prognostic significance.Two hundred thirty‐seven of 270 normal individuals tested had 29°C RFC levels greater than or equal to 47%, while 21 of 41 untreated cancer patients had higher levels. Cancer patients with depressed 29°C RFC usually normalized within four weeks of operation. Serial studies of 29°C RFC were performed on 32 stage I and II lung cancer patients. Eight patients have developed recurrent tumor. We noted a pattern of falling rosette values (two or more consecutive values within normal limits followed by two consecutive depressed values) in five of these patients an average of five months before clinical relapse. Fifteen patients who have remained disease free either maintained normal levels of rosettes or increased into the normal range. Four of 13 (31%) stage I and four of nine (44%) stage II breast cancer patients had depressed rosette levels preoperatively. In seven stage II patients with no further therapy after mastectomy, only two of 27 serial tests showed low RFC. Twenty‐six stage II patients receiving L‐phenylalanine mustard (L‐PAM) therapy after mastectomy were depressed in 18 of 90 (20%) serial tests. Twenty‐one patients receiving cyclophosphamide, methotrexate, and 5‐fluorouracil (CMF) after mastectomy were depressed in 25 of 73 (34%) serial tests. In contrast, seven patients treated with CMF and additionally with Corynebacterium parvum after mastectomy were depressed in eight of 27, or 29%, of serial tests. The 29°C E‐rosette assay gives reproducible counts of a T‐cell subset. Serial monitoring of patients with “high‐affinity” rosette‐forming cells may predict relapse earlier than clinical evaluation. This T‐cell population, depressed by chemotherapy, may be restored by immunopotentiators.
Serial CEA levels in colorectal carcinoma on adjuvant immuno(chemo)therapy—further follow‐up. Modulation of adjuvant treatment
Authors: Sopranzi N. , Ponzini D. , Di Paola M. , Inserra A. , Colizza S. 
Published: February 2007

AbstractSerial plasma CEA levels have been studied preoperativelyd (testing A); one day after surgery (B); 10–15 days after surgery (C); 4 (D), 8(E), 12 (F), 16–18 (G), and 22–24 (H) months after surgery in a series of 45 patients affected by colorectal carcinoma who started soon after surgery a protocol of adjuvant immuno(chemo)therapy with Levamisole and BCG. Postoperative follow‐up was from one to 26 months, with 28 patients followed for at least one year. Fourteen patients had recurrences: two of these had false‐negative CEA tests, three had persistent high CEA levels after surgery, nine had increasing levels 9 12 months before clinical recurrence; and nine of these 14 patients showed frankly pathologic preoperative plasma CEA levels. Six patients who did not have a recurrence but (both at clinical and instrumental evaluation) who had two consecutive high plasma CEA levels, were put on prophylactic polichemotherapy. The prognostic importance of CEA levels both pre‐and postoperatively, the possibility of “modulating” postoperative adjuvant treatments on the basis of CEA levels, and the problem of unexplained fluctuations of plasma CEA levels with the putative metabolic linkages are discussed.
Tumor antigens as related to pancreatic cancer
Authors: Chu T. Ming , Holyoke E. Douglas , Douglass Harold O. 
Published: February 2007

AbstractData are presented suggesting the presence of pancreas tumor‐associated antigens. Slow progress has been made during the past few years in the identification of pancreatic tumor antigens that may be of clinical usefulness and it seems unlikely that many of the practical problems now being faced in identification and isolation of these antigens and in development of a specific, sensitive assay will be solved by conventional immunochemical approaches. The study of antigen and/or antibody purified from immune complexes in the host and the application of leukocyte adherence inhibition techniques to immunodiagnosis of pancreatic cancer are among the new approaches that may provide effective alternatives in the study of pancreatic tumor antigens.
Lymph node dissection in malignant melanoma
Authors: Karakousis C. P. , Stahl L. , Moore R. , Holyoke E. D. 
Published: February 2007

AbstractRegional node dissection was performed in 120 patients with malignant melanoma. Patients with clinically negative nodes had a 90% survival, where‐as patients with enlarged nodes had a 15% survival. In 45 inguinal dissections, usually associated with a high morbidity, there was only a 4.5% incidence of infection and a 6.5% incidence of skin edge necrosis. For all types of node dissection, the overall incidence of wound infection was 5.8%, and that of necrosis of skin edges was 5%.
Hepatic arterial infusion chemotherapy for cancer of the liver
Authors: Bland Kirby I. , Knutson Carl O. , Max Martin H. 
Published: February 2007

AbstractHepatic artery infusion chemotherapy (HAIC) provides objective palliation for unresectable primary and secondary liver neoplasms. By utilizing HAIC rather than systemic chemotherapy, a greater concentration of the chemotherapeutic agent(s) within the liver is achieved with a comparative decrease in toxic side effects. A review of pertinent literature disclosed response rates of 50–71% associated with the administration of 5‐fluorouracil (5‐FU) and 5‐fluoro‐2‐deoxyuridine (5‐FUDR) via the hepatic artery, whereas response rates of 0–25% have been tabulated for systemic chemotherapy.
The effects of endotoxin on CFU‐C clonogenic capacity of marrow and spleen cells from RLV‐A infected mice
Authors: Koltun L. A. , Lobue J. , Gordon A. S. , Fredrickson T. N. 
Published: February 2007

AbstractBacterial endotoxin was used as a granulopoietic stressor in the RLV ‐A infected mouse as a means of studying the marrow and spleen CFU‐C response to this agent. A control group of phenylhydrazine (PHZ)‐treated mice was also employed to induce a reduction in hematocrit levels equivalent to that observed in the early and mid‐stage of the disease course and was used to determine whether the cloning observed was a manifestation of RLV ‐A disease or could be attributed solely to the resulting anemia. Both RLV ‐A infected and PHZ marrow from mice maintained at a hematocrit of 40% exhibited similar but higher than normal clonogenic capacities, whereas RLV‐A (hematocrit 40%) spleen had an expanded number of CFU‐C's when compared to PHZ treated (hematocrit 40%) mice. Examination of spleens of endotoxin‐treated RLV‐A (hematocrit 30%) infected mice indicated a 6 to 7‐fold increase in splenic CFU‐C numbers compared to endotoxin‐treated normal mice. PHZ plus endotoxin‐treated normal animals (hematocrit 30%) had splenic CFU‐C values which were approximately half those of RLV‐A infected (hematocrit 30%) endotoxin‐treated animals. Results of this experiment suggest a fully operable but greater than normal CFU‐C storage pool in the RLV‐A infected mouse spleen which does not seem to be due entirely to the anemia.
Coagulation problems in patients with cancer
Authors: Mitchell William H. , Parson B. J. , Althaus J. 
Published: February 2007

AbstractThe cases of 43 cancer patients and nine patients without cancer were reviewed to assess the coagulation mechanism in patients with cancer. Of the 43 patients with cancer, at least one factor known to be associated with coagulation disturbances was present in 26. Hematologic or coagulation studies disclosed one or more abnormalities in 34 of the patients. A subgroup of 17 patients had no clinical or laboratory evidence of ongoing variables that should interfere with coagulation or hemostasis. Of these, 11, or 65%, had one or more abnormal results from coagulation studies. Of the nine members of the control group (patients without cancer), no patient had a positive history for a clinical coagulation disorder except for one incidence of thrombophlebitis in the year preceding the study. During the study, at least one coagulation abnormality was disclosed by hematologic testing. The results support the concept that coagulation problems in cancer patients are attributable to debilitation, multiple organ involvement, and coagulation‐interfering variables rather than to a primary effect of the malignant tumor.
Uptake of 5‐fluorouracil during isolated perfusion of the canine liver
Authors: Stone Richard T. , Jabour Adel , Wilson Samuel E. , Rangel Decio M. 
Published: February 2007

AbstractThis study describes a technique of hepatic isolated perfusion in dogs. The uptake of 14 C‐Iabeled 5 fluorouracil (5‐FU) by the normal canine liver was fourfold greater when isolated perfusion was used than when peripheral intravenous administration or hepatic artery infusion were applied. Systemic leakage of 5‐FU was small during, and even following, hepatic isolated perfusion. This technique, which maximizes chemotherapy delivery to the liver while minimizing systemic toxicity, may be useful in the treatment of primary and metastatic hepatic malignancies.
Nonfunctional preaortic paraganglioma: Report of one case
Authors: Crisci E. , Montagnini R. , Bracci F. , Conte F. , Bigotti A. , Colizza S. 
Published: February 2007

AbstractA case of nonfunctional benign preaortic paraganglioma is reported. The patient, a woman aged 50, complained of vague mesogastric pain irradiated posteriorly, occasional nausea and vomiting, related to a tender pulsatile mesogastric mass fixed to the posterior wall of the abdomen. Preoperative diagnostic examinations showed a severe anemia, a severe mechanical impairment of renal function as shown at IVP, a doubt of aortic aneurism at echography, not confirmed by selective arteriography. The mass was removed radically. The diagnosis of nature was only microscopic. Since from 15 days after surgery IVP improved significantly. At three months follow‐up the patient is well with no sign of recurrence.
Pancreatic polypeptide cell hyperplasia with and without watery diarrhea syndrome
Authors: Tomita T. , Kimmel J. R. , Friesen S. R. , Mantz F. A. 
Published: February 2007

AbstractTwo cases of pancreatic polypeptide cell hyperplasia were obtained by operation. The first case exhibited adenocarcinoma of the stomach with metastases to the neck lymph nodes and pancreatic polypeptide hypersecretion. Pancreatic polypeptide cell hyperplasia was confirmed by the immunoperoxidase method and by the elevated level of pancreatic polypeptide in the pancreatic extracts and in the circulating blood. There was no watery diarrhea syndrome. The second case presented with persistent watery diarrhea of two and one‐half year duration, and the resected pancreas contained extremely large atypical islets, exclusively composed of pancreatic polypeptide cells. It is speculated that in some cases pancreatic polypeptide oversecretion may be causative for pseudo‐Verner‐Morrison syndrome in the absence of ulcer or carcinoma in the upper gastrointestinal tract.
Primary carcinoma of the gallbladder: A review of 328 cases
Authors: Gupta S. , Udupa K. N. , Gupta Saroj 
Published: February 2007

AbstractA ten‐year retrospective study of 328 histologically proven cases of primary carcinoma of the gallbladder between 1967 and 1976, with a two‐year minimum follow‐up was undertaken. The overall incidence was 2.9% of all cancer cases and 31.8% of all malignant tumours of the gastrointestinal tract. Male to female ratio was 1:2.64. The disease occurred on the average at a younger age in females (43 years) than in males (50 years). Pain and lump in the right upper abdomen were the commonest clinical features. Laboratory and radiological investigations most often confirmed the diagnosis of advanced disease. The majority (80.8%) were adenocarcinomas. In all the 42 cholecystectomized patients association of gallstones was noted, but as in the majority of cases laparotomy biopsy alone was done, no mention of gallstones was recorded. Five‐year survival rate of only 1.8% suggests extensive use of prophylactic cholecystectomy.
The relation between testicular tumours, undescended testes, and inguinal hernias
Authors: Wobbes Th. , Koops H. Schraffordt , Oldhoff J. 
Published: February 2007

AbstractA group of 230 patients with a malignant testicular tumour was found to include 12 patients with a history of an undescended testis (5.2%). Eight patients had a history of inguinal hernia (3.4%). The risk of malignant degeneration in an undescended testis proved to be 17 times greater than in the normal population. We found no increased risk for patients with a history of inguinal hernia. Nine patients with a history of orchiopexy developed a malignant testicular tumour; inguinal lymph node metastases were found in three of them. We advise the removal of all undescended testicles after puberty. In cases of malignant degeneration of a testis, which have been fixed in the scrotum, or in cases with a history of an operation in the inguinal region, the inguinal lymph nodes have to be treated. For seminoma, irradiation of these nodes is necessary; for non‐seminoma tumours, hemiscrotectomy and inguinal lymph node dissection have to be performed.
Lymph node biopsy for diagnosis: A statistical study
Authors: Lee YEU‐TSU N.(Margaret) , Terry Roger , Lukes Robert J. 
Published: February 2007

AbstractThis is retrospective and all inclusive study of 925 patients who had isolated lymph node biopsies for diagnosis from 1973 to 1977. Overall, 60% of the nodes had benign lesions, 28% carcinoma, and 12% lymphoma. The comparable figures for abdominal nodal biopsies were 63%, 33% and 4%; for intrathoracic nodes, 73%, 26% and 1%; for peripheral nodes, 56%, 29% and 15%. Detailed distribution according to specific site of nodal biopsy, histological subtypes, age, and sex of patients are presented. Statistically, age is the most important factor useful in estimating the probability of whether the lymphadenopathy is due to a benign or malignant process.
Studies of tumor implants in immunologically privileged sites
Authors: Wajsman Z. , Williams P. , McGarry M. , Murphy G. P. 
Published: February 2007

AbstractWilms' tumor, renal cell carcinoma, and neuroblastoma in animals were transplanted from donors to recipients with strong histocompatibility differences. No strong evidence of the privileged site theory was found in this study and no obvious evidence of an immunosuppressive effect of testosterone was found.The most important factor noted in these studies was that the take of tumor transplant seems to be related more to the type of tumor itself. Further studies of transplant results of such different types of tumors are warranted and are being conducted. An interaction between the hormonal supportive concept and the privileged site seems tenable.
The value of laparoscopic liver examination in the management of breast cancer
Authors: De Souza L. J. , Shinde S. R. 
Published: February 2007

AbstractOne‐hundred selected breast cancer patients underwent a laparoscopic liver examination to evaluate this procedure in the management of breast cancer. Group I contained patients with primary breast tumors considered to be localized. Group II consisted of cases which had disseminated disease at initial evaluation or had recurrent disease. In group I, 8.5% showed macrometastases less than 1 cm in size at laparoscopy in clinically uninvolved livers. This converted a presumed localized lesion to stage IV disease and was managed accordingly. Cases evaluated as high‐risk cases due to local factors, however, were not found to have liver involvement at laparoscopy, and hence adequate local therapy could be undertaken. In group II, metastatic liver involvement detected at laparoscopy was 22.5%. This simple, safe, and short procedure is therefore felt to be a useful complementary investigation in the management of breast cancer.
The diagnosis and treatment of obstructive jaundice secondary to malignant lymphoma: A problem in multidisciplinary management
Authors: Boddie A. W. , Eisenberg Burton L. , Mullins James D. , Schlichtemeier A. Lee 
Published: February 2007

AbstractApproximately 1.3% of patients with lymphoma develop obstructive jaundice secondary to lymphomatous involvement of the extrahepatic biliary system. This may occur either as an initial or as a late manifestation of disease. Clinically and radiographically the condition may mimic a variety of more common causes of obstructive jaundice. Surgical exploration may be necessary to confirm the diagnosis, but local radiotherapy would appear to be the preferred mode of treatment. Rapid progression to systemic disease occurs in the majority of patients, necessitating multidrug chemotherapy. Control of jaundice by radiotherapy is good, but long‐term prognosis is poor. Supervening sepsis and gastrointestinal bleeding caused the majority of deaths, suggesting that adjunctive nutritional support, immunologic enhancement, and stress ulcer prophylaxis may be necessary if survival is to be improved.
Malignant pheochromocytoma (paraganglioma) of the organ of zuckerkandl: A study of two cases
Authors: Herrera Lemuel O. , Hossain Zakir M. , Rafal Harold S. , Frelick Robert W. , Ashley Patrick F. , Lopez Gloria E. 
Published: February 2007

AbstractTen percent of pheochromocytomas are found in extra‐adrenal locations and are called paragangliomas. In recent years we have had the opportunity to study two patients with malignant paragangliomas of the organ of Zuckerlandl. Only 13 cases of such neoplasms have been reported previously. Our cases are of interest because of their features of recurrence, distant metastases, response to adjuvant therapy, and long survival.
Extramedullary plasmacytoma: Simulating a soft tissue sarcoma of the chest wall
Authors: Sanyal B. , Pant G. C. , Sahni K. , Khanna S. , Gupta R. M. , Khanna N. N. 
Published: February 2007

AbstractExtramedullary plasmacytoma occurs infrequently as compared to osseous myoloma. A single case of extramedullary plasmacytoma was seen during the last 10 years whose initial presentation was that of a soft tissue sarcoma of the chest wall. Clinical data along with relevent investigation and treatment results are discussed with a review of the literature.
Mammary carcinoma — multidisciplinary treatment with bilateral mastectomy and immediate reconstruction
Authors: Gentil Fernando , Callia William , De Souza e Sá Arthur , Cavalcanti Silvio , Garcia Elme , Filho Oswaldo Giannotti , Varella Antonio Drauzio 
Published: February 2007

AbstractThe classical concepts pertaining to the natural history of mammary carcinoma and its treatment must be reviewed if survival rate is to be improved. By the time diagnosis is established, a fair amount of cases of carcinoma of the breast present distant, clinically undetectable micrometastases, which will not be affected by local therapy (surgery or radiation). Increasing evidence shows that mammary carcinoma nowadays must be looked upon as a diffuse disease affecting both breasts. Postoperative radiation does not improve the 5‐ and 10‐year survival rates and has a negative effect upon the immunological defense of the patient. Immunology plays an important role in the evolution and cure of the patient with carcinoma of the breast. The mutilation produced by radical or ultraradical mastectomy may throw the patient into mental depression which, as a consequence, may decrease the immunological competence of the patient. Multiple drug chemotherapy, started at the time of surgery and continued for several months thereafter, may kill micrometastases. Preventive immunotherapy seems to be beneficial to the patient in attempting control of metastases.