bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Physiological Role of Parathyroid Hormone and Serum Calcium in Odontogenesis Stunting Children; Cross-sectional Analysis of Children Attending Dental OPD and Paediatric Ward at LUMHS
Authors: Shadab  , Munwar Baloch  , Sana Javed Khoso  , Faiz Muhammad Khoso  , Sajid Ali Majeedano  , Fida Baloch  
Published: April 2024

Objectives: To determine serum PTH and serum calcium levels among children with delayed eruption of permanent teeth, attending the dental OPD at LUMHS.
Methodology: A cross-sectional study was conducted with the assistance of the Physiology Department, LUMHS, in collaboration with the Clinical Ward, Pediatric and Dental Wards, and D-R Lab, LUMHS, from March to August 2022. Children up to 18 years old, corresponding to the period of active odontogenesis and growth, diagnosed with odontogenesis stunting characterized by delayed or disrupted tooth development, as confirmed by clinical examination and radiographic imaging, visiting the dental outpatient department (OPD) were included. Blood samples for PTH and serum calcium levels were obtained with the informed consent of parents. Parathyroid Hormone was considered normal from 10 to 55 picograms/ml.
Results: A total of 250 children were studied, with an overall mean age of 12.24 ± 12.0 years. Males comprised 60.4%, and females were 39.6%. Most cases (28.4%) had dentine score 0, 24.8% had dentine score I, 24.8% had dentine score II, 18.8% had dentine score IV, while only 3.2% had dentine score II. Mean parathyroid hormone levels were significantly associated with higher dentine scores (p < 0.05). Although mean parathyroid hormone levels were statistically insignificant according to children's age (p < 0.05).
Conclusion: A decrease in levels of parathyroid hormones and calcium has been observed to contribute to the delay in the eruption of primary teeth. Additionally, factors such as stunted growth and deficiencies in parathyroid hormones and calcium levels further exacerbate this delay, highlighting the importance of adequate nutrition in dental development.
Clinical Outcomes and Quality of Life Following TEVAR with or without Revascularization of the Left Subclavian Artery
Authors: Şengör Mehmet , Akbulut Mustafa , Taş Serpil , Şişmanoğlu Mesut 
Published: April 2024

Objectives: This study aims to evaluate the clinical outcomes and quality of life of patients with or without the left subclavian artery (LSA) revascularization in patients with thoracic aortic diseases undergoing endovascular repair of the ishimaru zone 2.
Methods: A total of 48 patients with the closure of the LSA after thoracic endovascular aortic repair (TEVAR) were enrolled in the study between 2014 and 2018, of whom 21 had undergone the LSA (revascularization group), and the remaining 27 cases (non-revascularization group). The study was planned as a single-center retrospective design. Data were retrieved from the patients’ files. Short form-36 scales were administered to assess quality of life.
Results: There was no difference between the two groups with and without LSA revascularization in 30-day paraplegia (4.8% vs. 0.0%, p=0.449), 4-year cerebrovascular events (0.0% vs. 3.8%, p=0.998), upper extremity ischemia (9.6% vs. 0.0%, p=0.207), death (28.6% vs. 25.9%, p=0.887), rate of endoleak (23.8% vs. 29.6%, p=0.896), and length of intensive care unit stay (2.3±2.1 days vs. 2.1±1.8 days, p=0.645). Regarding the quality of life, only physical functioning was improved slightly more in the group that underwent LSA without revascularization (90.7±26.7 vs. 82.3±14.9, p=0.032).
Conclusion: The current study showed no significant differences with respect to neurological outcomes, upper extremity ischemia, quality of life, and mortality among patients undergoing TEVAR with or without revascularization of the LSA.
Inebilizumab (Uplizna)
Authors: CADTH  
Published: April 2024

CADTH recommends that Uplizna be reimbursed by public drug plans for the treatment of neuromyelitis optica spectrum disorder (NMOSD), if certain conditions are met.
Uplizna should only be covered to treat adult patients who are anti-aquaporin-4 immunoglobulin G (AQP4-IgG) seropositive and who have had at least 1 NMOSD relapse episode (also known as an “attack”) in the 1 year before initiation, or 2 NMOSD relapse episodes in the 2 years before initiation. Patients must have an Expanded Disability Status Scale (EDSS) score of 8 points or less.
Uplizna should only be reimbursed if it is prescribed by neurologists with expertise in treating NMOSD and the cost of Uplizna is reduced to be no greater than the least costly comparator currently reimbursed for the treatment of NMOSD. Uplizna should not be initiated during a NMOSD relapse episode or when used in combination with rituximab, satralizumab, eculizumab, or ravulizumab.
Etude De Dosage Des Eléments Minéraux Dans Quelques Espèces Des Chenilles Comestibles Consommées A Kinshasa
Authors: FALANGA Junior MATONDO , NSELE Beni BOSINGA , KUSONGA SUKUMI , MBUYI Shekinah , DUABA Daddie , MPIA Patience NGELINKOTO 
Published: April 2024

L’objectif général de ce travail est de faire une étude comparative entre les teneurs en oligo-éléments et macroéléments dosés dans les quatre espèces de chenilles dont Imbrasia oyemensis ROUGEOT, Imbrasia epimethea DRURY, Cirina forda WESTWOOD et Elaphrodes lactea GAEDE pour se faire une idée sur l’apport nutritionnel que chacune apporte dans l’organisme. Les chenilles sèches sont broyées et conservées dans des flacons ensuit envoyées au laboratoire de l’OCC à LUBUMBASHI pour l’analyse minérale. Les éléments minéraux dosés dans ces échantillons des chenilles sont : Ca, Na, K, Mg, Cu, Co, Fe, Se et Mn. Cette analyse est effectuée par ICP-AES. Les données recueillies à l’issue de cette analyse ont été soumises à des traitements statistiques. L’analyse des variances (anova-one-way) selon le test de comparaison multiple de Turkey. Si p < 0,05, la différence est considérée significative enfin de séparer les quatre échantillons de chenilles par rapport à leurs teneurs en éléments minéraux. Sachant que la chenille est un aliment d’habitude pour la plupart des familles dans notre pays, à cause de sa teneur en protéines et lipide. Elle présente aussi une source importante en éléments minéraux. En tenant compte de la toxicité de ces éléments et en considérant la teneur journalière de chaque élément qu’un aliment peut apporter dans l’organisme, nous suggérons aux consommateurs des consommer pour leurs alimentation la chenille Cirina forda WESTWOOD.
Potential Analysis Of Peatland Fire In Ogan Komering Ilir District
Authors: Muslikah Siti , Yuliani Yuliani 
Published: April 2024

Based on data from CIFOR (Center for International Forestry Research), there are 3 million hectares of wetlands in South Sumatra, with an area of 1.73 million hectares of peatland. Around 796,000 hectares of peatland are located in the district of Ogan Komering Ilir. Almost every year peatland fires occur in this area. Therefore, it is necessary to mitigate the disaster of peatland fires by analyzing the potential level of vulnerability to peatland fires in Ogan Komering Ilir Regency. There are five sub-districts that are sampled in this study, namely Kayuagung, Tulung Selapan, Pedamaran Timur, Pangkalan Lampan, and Pedamaran District. The parameters reviewed were based on the type of land cover, the maturity level of the peatlands, and the water level of the peat soil. In addition, the potential for peatland fires is seen from the intensity of rainfall. Because the potential for peatland fires is higher if they occur during the dry season where rainfall intensity is low or during dry months. The results showed the potential for peatland fires based on the characteristics of peatlands in Ogan Komering Ilir Regency has a moderate to high level. While the analysis is based on the intensity of rainfall, the potential for peatland fires from July to November which is a dry month with rainfall intensity < 100mm. .
Efficacité Des Messages De Prevention : Effet Du Cadrage, Des Croyances Et De La Vividité Sur Les Messages De Prevention
Authors: SAMOUTH Aka Georges fabrice 
Published: April 2024

La sécurité routière est un problème de santé publique, mettre en place une campagne de prévention efficace devient un impératif pour le gouvernement. Dans une étude expérimentale, nous avons cherchés à déterminer les facteurs susceptibles d’accroitre l’efficacité des messages de prévention. Pour atteindre cet objectif, nous avons interrogés 200 sujets au sein de l’université Felix Houphouët-Boigny d’Abidjan répartis de façon aléatoire dans quatre conditions de l'expérience issues du plan factoriel 2 (cadrage : positif vs négatif) x 2 (vividité du message : vividité faible vs vividité forte). Un test de ki2, une analyse de variance multivariée et un test de régression ont montrés l’efficacité des messages cadrés négativement par rapport aux messages cadrés positivement, ainsi celles de la vividité et du fatalisme sur la pris de décision et l’intention comportement dans l’élaboration d’un message de prévention.Mots clés : message, prévention, cadrage, vividité, fatalisme.
Prévalence Et Facteurs Associés Au Faible Poids De Naissance A l’Hôpital Provinciale Général De Référence De Kinshasa
Authors: BONGOLU Bienvenu RAMAZANI , TABORA Justin RAMAZANI , ONASAKA Léon SHONGO 
Published: April 2024

Le faible poids de naissance constitue un problème majeur de santé publique touchant une population, aussi bien dans les pays en voie de développement que dans les pays développés. Il est classiquement dû à deux causes qui sont parfois associées à la prématurité et l’hypotrophie. La naissance d’un nouveau-né de FPN est le reflet de l’état de santé de la mère que la prestation sanitaire. La prévention est possible grâce aux interventions ciblées sur les facteurs de risque modifiables, qui ont fait preuve d’efficacité dans plusieurs pays du monde.C’est ainsi que nous avons voulu contribuer à l’amélioration de FPN à l’HPGRK en menant une étude basée sur analyse documentaire et rétrospective des dossiers médicaux des FPN a couvert la période allant du 1er janvier au 31 décembre 2016. Il ressort de cette étude que le FPN est un problème réel à l’HPGRK qui est associé à l’infection néonatale + HCM et aux habitudes toxiques des mères durant la grossesse et le tabagique passif.
Implications Socio-Économiques Des Infrastructures Marchandes Dans Le Développement De La Commune De Glazoué
Authors: HESSOU Paulin Mintongninou , HOUINSOU Tognidè Auguste , HONVO Z. S. Aser 
Published: April 2024

Pour faire face aux défis de financement du développement des collectivités décentralisées au Bénin, les communes font recours aux ressources générées par les infrastructures marchandes. Celles de la commune de Glazoué contribuent tant bien que mal au développement local. La présente recherche vise à analyser la contribution des infrastructures marchandes dans les ressources propres générées par la commune de Glazoué.L’approche méthodologique adoptée pour conduire cette recherche s’articule autour de la collecte des données, leur traitement et à l’analyse des résultats. Au total, 228 personnes constituées d’usagers des marchés, de personnes ressources et des agents de la Mairie, ont été interrogés.Les résultats obtenus montrent que, la commune de Glazoué dispose de 08 marchés locaux et de 04 marchés régionaux. Les recettes générées varient d’un marché à un autre. Sur la décennie considéré la commune de Glazoué a enregistrée 728 073 929 F CFA pour les droits de places, les taxes sur hangar et les frais de loyer. Les recettes les plus élevées sont réalisés en en 2012, 2020 et 2021 soit respectivement 131 816 100 F CFA, 81 557 418 F CFA et 99 394 709 F CFA. Dans l’ensemble ces recettes ont contribué à 7,36 % au renforcement du budget de la commune avec une moyenne annuelle de 7,81 %. Une partie de ces fonds permet aux communes de financer seules ou avec l’aide des PTF et de l’Etat central, la construction des infrastructures sociocommunautaires.
PENINGKATAN HASIL BELAJAR IPS TENTANG SEJARAH HINDU BUDDHA DI KELAS VII-C SMPN 2 KUTOREJO DENGAN MODEL PROBLEM BASED LEARNING
Authors: Sundaryani Sundaryani 
Published: April 2024

Pembelajaran IPS di kelas VII-C SMP Negeri 2 Kutorejo Mojokerto, belum seluruhnya menggambarkan kegiatan pembelajaran yang berbasis pada kegiatan siswa. Hal ini berdampak pada rendahnya hasil ulangan harian tentang Peninggalan Sejarah Hindu Buddha. Pada ulangan harian, diperoleh nilai rata–rata kelas sebesar 54,5 dan ketuntasan belajar secara klasikal mencapai 41,9%. Hal ini menunjukkan bahwa ada 13 siswa dari 31 siswa sudah tuntas belajar. Pembelajaran belum mencapai ketuntasan klasikal, karena siswa yang memperoleh nilai ³ 70 hanya sebesar 41,9% lebih kecil dari persentase ketuntasan klasikal sebesar 85%. Maka melalui penelitian tindakan ini, peneliti ingin meningkatkan prestasi belajar IPS dengan menerapkan model problem based learning. Penelitian dilaksanakan dalam dua siklus, dimana masing-masing siklus dilaksanakan dalam dua pertemuan. Analisis data penelitian ini adalah deskriptif persentase. Data hasil penelitian yang dianalisis meliputi rata-rata kelas, ketuntasan belajar individu dan ketuntasan belajar secara klasikal. Selanjutnya hasil analisis data diperolah baik kualitataf maupun kuantitatifBerdasarkan uraian pembahasan, diperoleh simpulan bahwa model problem based learning sangat efektif untuk meningkatkan prestasi belajar IPS tentang Peninggalan Sejarah Hindu Buddha. Penerapan model problem based learning pada pelajaran IPS tentang Peninggalan Sejarah Hindu Buddha, diawali dengan memberikan tugas kepada siswa untuk mengadakan observasi dan wawancara kepada masyarakat sekitar tentang agama dan tradisi yang dilaksanakan. Pada kegiatan pembelajaran lanjutan, siswa diberi tugas membuat kliping berikut ulasan /rangkuman dari artikel-ratikel yang ada.
PENGARUH TERAPI RELAKSASI OTOT PROGRESIF TERHADAP STRES PERAWAT INSTALASI GAWAT DARURAT RUMAH SAKIT
Authors: Imardiani  
Published: April 2024

Latar belakang: Perawat yang bertugas di ruangan instalasai gawat darurat (IGD) dituntut untuk memiliki kemampuan lebih dibanding dengan perawat yang melayani pasien di ruang yang lain. Hasil survey PPNI tahun 2016 didapatkan data bahwa sekitar 50,9% perawat di Indonesia mengalami stress kerja. Stress kerja perawat di instalasi gawat darurat lebih tinggi dibandingkan dengan stresor kerja perawat di unit lainnya sehingga jika tidak segera ditangani akan berdampak pada individu perawat, pasien serta lingkungan kerja. Untuk mengatasi kondisi stress kerja perawat di instalasi gawat darurat dapat dilakukan dengan cara melakukan terapi relaksasi otot progresif yang terbukti berpengaruh terhadap penurunan tingkat sress pada perawat. Tujuan penelitian : diketahuinya pengaruh terapi relaksasi otot progressive terhadap stress perawat instalasi gawat darurat RSUD Gelumbang Kabupaten Muara Enim. Metode penelitian : penelitian ini menggunakan metode pre-eksperimen dengan desain one group pre and post test yang menggunakan metode sampel purposive sampling dengan jumlah 17 orang perawat di Instalasai Gawat Darurat RSUD Gelumbang. Hasil : hasil penelitian didapatkan nilai stress perawat sebelum dilakukan intervensi yaitu 173,53 dan nilai sesudah dilakukan intervensi yaitu 154,29 serta nilai p value 0,0001 (<0,05). Simpulan : Terdapat pengaruh yang signifikan antara pemberian terapi otot progresif terhadap stress perawat di Instalasi Gawat darurat RS
Impaired kidney function among young healthcare workers with long working hours and night work
Authors: Chen Wan-Chin , Yang Hsiao-Yu 
Published: April 2024

OBJECTIVES: We aimed to evaluate the association between long working hours, night work, and estimated glomerular filtration rate (eGFR) among young healthcare workers.
METHODS: We conducted a retrospective cohort study among healthcare workers in a tertiary medical center in Taiwan from 2002 to 2021. Other than physicians, all hospital employees aged 20–65 years with documented yearly working hours and an annual blood test including creatinine were eligible. We excluded participants with eGFR <60 ml/min/1.73 m2 and proteinuria at enrollment to focus on early renal impairment. Total working hours, night working hours, and eGFR in each year were collected. We assessed the relationship of total working hours and night and non-night working hours with eGFR using the generalized linear mixed model, adjusting for demographic, comorbidities, and laboratory profiles.
RESULTS: The study included 10 677 participants with a mean age of 27.2 (standard deviation 7.1) years. The mean follow-up duration was 6.2 years. For every 10-hour increase in total weekly working hours, the eGFR decreased by 0.86 [95% confidence interval (CI) 0.61–1.11] ml/min/1.73 m2. For every 10-hour increase in weekly night working hours, the eGFR decreased by 0.25 (95% CI 0.07–0.42) ml/min/1.73 m2. In stratified analysis, the negative associations between total working hours and eGFR remained in the subgroups of individuals aged <40 years and those without hypertension or diabetes, with a P-value for interaction of <0.05.
CONCLUSIONS: Longer working hours and night work were associated with lower eGFR among healthcare workers.
CYP2C19 gene variants and major depressive disorder: integrative review
Authors: Dias dos Santos Ayssa Natália , Sousa Silva Bonasser Larissa , De Souza Silva Calliandra Maria , Ferreira Fratelli Caroline , Rodrigues da Silva Izabel Cristina , Lira de Sa Barreto Livia Cristina 
Published: April 2024

Major depressive disorder (MDD) is a multifactorial condition common in the general population, treated with different antidepressants. Several genes are involved in the metabolism of these antidepressants, including CYP2C19. Consequently, functional polymorphisms in these genes affect these drugs' metabolism. Through an integrative review, this research aimed to verify the CYP2C19 gene polymorphisms' influence on antidepressant metabolism, evaluate their frequency in patients affected by MDD, verify clinical and demographic characteristics of studied populations, and identify possible associations of this gene with MDD. The database used to search for articles was Biblioteca Virtual em Saúde - BVS, and four articles were selected. Polymorphisms in the CYP2C19 gene may contribute to the metabolism of some antidepressants, such as citalopram, but not others, such as venlafaxine and sertraline. Interestingly, the drug sertraline can influence the levels of lipid profile parameters. In addition, some polymorphisms may be relatively frequent depending on the populations, such as Asians. No CYP2C19 polymorphisms associated with MDD development were observed.
Reseña del libro Crisis ecológica.
Authors: Agosta Scarel Eduardo 
Published: April 2024

La crisis ecológica no puede ser abordada si no es interdisciplinariamente. El libro “Crisis Ecológica” aporta mirada integral a través de la reflexión y el diálogo cordial entre teología, filosofía, historia, economía y trabajo social, y la expresión concreta de su mensaje en el ámbito de las relaciones internacionales, el problema de la contaminación local y la educación.
Abordar la cuestión ecológica requiere un cambio de mentalidad, que converge como punto de llegada en el concepto eco-teológico de ecología integral, que ofrece la encíclica Laudato Si’ del Papa Francisco. Esto invitará luego a una respuesta humana, una praxis, como punto de partida del profundo cambio necesario en la cultura, la economía, la tecno-ciencia y la política globales, a modo de conversión ecológica personal y comunitaria, a la que invita la encíclica, que será referida en un segundo tomo siguiente al presente texto.
FlashFluent: uma ferramenta para o aprendizado de uma língua estrangeira no âmbito da dislexia
Authors: Lima Letícia de Godoy , Moraes Antonio Coutelo de , Madeiro Francisco , Cidrim Luciana 
Published: April 2024

Aprender uma língua estrangeira não apenas fortalece competências linguísticas, mas também desempenha um papel fundamental no desenvolvimento cultural, pessoal e profissional do indivíduo e de acesso amplo à informação. No entanto, para uma parcela significativa da população, o domínio da aprendizagem de uma língua estrangeira se torna complexo, em especial para pessoas com dislexia, pois tanto pode afetar o desenvolvimento das competências cognitivo-linguísticas da primeira língua, como pode também influenciar a aquisição de línguas adicionais. Nesse sentido, este artigo apresenta um website, FlashFluent, que foi idealizado como um espaço virtual amigável e adaptado, através do qual pessoas com dislexia possam colaborativamente aprimorar a aprendizagem de habilidades linguísticas, como vocabulário e pronúncia, em uma língua estrangeira. Nos últimos anos, a contribuição da tecnologia na área das dificuldades e transtornos de aprendizagem tem sido reconhecida. Com a tecnologia cada vez mais presente no nosso cotidiano, sua utilização pode ser útil e necessária, pois oferece práticas pedagógicas mais dinâmicas, colaborativas e interativas. A funcionalidade proposta pelo FlashFluent abrange tanto a facilidade no quesito familiaridade de novas palavras no vocabulário do usuário quanto a criação de uma rede em que as pessoas se sintam confortáveis para manter discussões e interagir com usuários em condições similares de aprendizagem. Destaca-se que o investimento em estratégias tecnológicas de ensino de língua estrangeira para disléxicos pode contribuir para o trabalho de profissionais na área da Educação.
Avicenna's Agent Intellect as a Completing Cause
Authors: Hennig Boris 
Published: April 2024

Abstract
Avicenna says that intellectual cognition involves the emanation of an intelligible form by the ‘agent intellect’ upon the human mind. This paper argues that in order to understand why he says this, we need to think of intellectual cognition as a special case of a much more general phenomenon. More specifically, Avicenna's introduction of an agent intellect will be shown to be a natural consequence of certain assumptions about the temporality, the completion, and the teleology of the causal processes by which things acquire forms.
Decreased histone expression in chronic rhinosinusitis with nasal polyps
Authors: Zhao Yanming , Zhang Nan , Perez Novo Claudina , Wang Yang , Zhang Luo 
Published: April 2024

Background:
Histones have been associated with human diseases. However, the implication of extranuclear histone proteins and their potential mechanism in the pathophysiology of chronic rhinosinusitis (CRS) have not been thoroughly investigated. This study was designed to evaluate the role of histones in patients with CRS by comparing histone expression between patients and controls.

Methods:
Nasal polyp (NP) tissues were obtained, and their comprehensive gene expression profiles were investigated by microarray analysis. Differences in expression were verified by reverse transcriptase polymerase chain reaction and immunohistochemical staining. Cell culture and flow cytometry were used to evaluate the role of histones in the pathogenesis of polyps.

Results:
Significant differences in the microarray analysis were observed between the patient and control groups (P < 0.01). It was found by flow cytometry that the histone (H2BK) can promote cell apoptosis in NPs.

Conclusion:
Our results indicate that reduced expression of H2BK may contribute to the imbalance process of cell proliferation and apoptosis in CRS with NP.