bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biological dose optimization incorporating intra-tumoural cellular radiosensitivity heterogeneity in ion-beam therapy treatment planning
Authors: Inaniwa Taku , Kanematsu Nobuyuki , Koto Masashi 
Published: April 2024

Abstract

Objective. Treatment plans of ion-beam therapy have been made under an assumption that all cancer cells within a tumour equally respond to a given radiation dose. However, an intra-tumoural cellular radiosensitivity heterogeneity clearly exists, and it may lead to an overestimation of therapeutic effects of the radiation. The purpose of this study is to develop a biological model that can incorporate the radiosensitivity heterogeneity into biological optimization for ion-beam therapy treatment planning. Approach. The radiosensitivity heterogeneity was modeled as the variability of a cell-line specific parameter in the microdosimetric kinetic model following the gamma distribution. To validate the developed intra-tumoural-radiosensitivity-heterogeneity-incorporated microdosimetric kinetic (HMK) model, a treatment plan with H-ion beams was made for a chordoma case, assuming a radiosensitivity heterogeneous region within the tumour. To investigate the effects of the radiosensitivity heterogeneity on the biological effectiveness of H-, He-, C-, O-, and Ne-ion beams, the relative biological effectiveness (RBE)-weighted dose distributions were planned for a cuboid target with the stated ion beams without considering the heterogeneity. The planned dose distributions were then recalculated by taking the heterogeneity into account. Main results. The cell survival fraction and corresponding RBE-weighted dose were formulated based on the HMK model. The first derivative of the RBE-weighted dose distribution was also derived, which is needed for fast biological optimization. For the patient plan, the biological optimization increased the dose to the radiosensitivity heterogeneous region to compensate for the heterogeneity-induced reduction in biological effectiveness of the H-ion beams. The reduction in biological effectiveness due to the heterogeneity was pronounced for low linear energy transfer (LET) beams but moderate for high-LET beams. The RBE-weighted dose in the cuboid target decreased by 7.6% for the H-ion beam, while it decreased by just 1.4% for the Ne-ion beam. Significance. Optimal treatment plans that consider intra-tumoural cellular radiosensitivity heterogeneity can be devised using the HMK model.
Super-resolution reconstruction of ultrasound image using a modified diffusion model
Authors: Liu Tianyu , Han Shuai , Xie Linru , Xing Wenyu , Liu Chengcheng , Li Boyi , Ta Dean 
Published: April 2024

Abstract

Objective. This study aims to perform super-resolution (SR) reconstruction of ultrasound images using a modified diffusion model, designated as the diffusion model for ultrasound image super-resolution (DMUISR). SR involves converting low-resolution images to high-resolution ones, and the proposed model is designed to enhance the suitability of diffusion models for this task in the context of ultrasound imaging. Approach. DMUISR incorporates a multi-layer self-attention (MLSA) mechanism and a wavelet-transform based low-resolution image (WTLR) encoder to enhance its suitability for ultrasound image SR tasks. The model takes interpolated and magnified images as input and outputs high-quality, detailed SR images. The study utilized 1,334 ultrasound images from the public fetal head-circumference dataset (HC18) for evaluation. Main results. Experiments were conducted at 2× , 4× , and 8× magnification factors. DMUISR outperformed mainstream ultrasound SR methods (Bicubic, VDSR, DECUSR, DRCN, REDNet, SRGAN) across all scales, providing high-quality images with clear structures and rich detailed textures in both hard and soft tissue regions. DMUISR successfully accomplished multiscale SR reconstruction while suppressing over-smoothing and mode collapse problems. Quantitative results showed that DMUISR achieved the best performance in terms of learned perceptual image patch similarity, with a significant decrease of over 50% at all three magnification factors (2× , 4× , and 8× ), as well as improvements in peak signal-to-noise ratio and structural similarity index measure. Ablation experiments validated the effectiveness of the MLSA mechanism and WTLR encoder in improving DMUISR’s SR performance. Furthermore, by reducing the number of diffusion steps, the computational time of DMUISR was shortened to nearly one-tenth of its original while maintaining image quality without significant degradation. Significance. This study demonstrates that the modified diffusion model, DMUISR, provides superior performance for SR reconstruction of ultrasound images and has potential in improving imaging quality in the medical ultrasound field.
Benefits of the Super-X divertor configuration for scenario integration on MAST Upgrade
Authors: Harrison J R , Bowman C , Clark J G , Kirk A , Lovell J , Patel B S , Ryan P , Scannell R , Thornton A J , Verhaegh K 
Published: April 2024

Abstract
The integration of good core and edge/pedestal confinement with strong dissipation of heat and particles in the divertors is a significant challenge for the development of fusion energy. Alternative divertor configurations offer potential advantages by broadening the operational space where a device can operate with detached divertors and acceptable power exhaust. First results from MAST Upgrade are presented from high confinement mode experiments with outer divertors in the Super-X divertor configuration, showing that the outer divertors naturally detach when the Super-X is formed with no discernible impact on the plasma core and pedestal. These initial findings confirm predicted benefits of the Super-X configuration in terms of facilitating scenario integration.
Stability of vortices in exciton-polariton condensates with spin–orbital-angular-momentum coupling
Authors: Yang Xin-Xin , Zhang Wei , Niu Zhen-Xia 
Published: April 2024

Abstract
The existence and dynamics of stable quantized vortices is an important subject of quantum many-body physics. Spin–orbital-angular-momentum coupling (SOAMC), a special type of spin–orbit coupling, has been experimentally achieved to create vortices in atomic Bose–Einstein condensates (BEC). Here, we generalize the concept of SOAMC to a two-component polariton BEC and analyze the emergence and configuration of vortices under a finite-size circular pumping beam. We find that the regular configuration of vortex lattices induced by a finite-size circular pump is significantly distorted by the spatially dependent Raman coupling of SOAMC, even in the presence of a repulsive polariton interaction which can assist the forming of stable vortex configuration. Meanwhile, a pair of vortices induced by SOAMC located at the center of polariton cloud remains stable. When the Raman coupling is sufficiently strong and interaction is weak, the vortices spiraling in from the edge of polariton cloud will disrupt the polariton BEC.
Quazinormal modes and greybody factor of black hole surrounded by a quintessence in the S-V-T modified gravity as well as shadow
Authors: Al-Badawi Ahmad 
Published: April 2024

Abstract
The purpose of this study is to investigate the quasinormal modes (QNMs), greybody factors (GFs) and shadows in a plasma of a black hole (BH) surrounded by an exotic fluid of quintessence type in a scalar-vector-tensor modified gravity. The effects of a quintessence scalar field and the modified gravity (MOG) field on the QNM, GF, and shadow are examined. Using the sixth-order WKB approach, we investigate the QNMs of massless scalar and electromagnetic perturbations. Our findings show that as the quintessence and the MOG parameter (ϵ and α) increase, the oscillation frequencies decrease significantly. Gravitational wave damping, on the other hand, decreases with increasing ϵ and α. In addition, we obtain an analytical solution for the transmission coefficients (GF) and demonstrate that more thermal radiation reaches the observer at spatial infinity as both the ϵ and α parameters increase. We also investigate the effect of the plasma background on the BH shadow and show that as the plasma background parameter increases, the shadow radius slightly shrinks. Nevertheless, the shadow radius increases as α and ϵ increase. Particularly intriguing is the fact that increasing ϵ has a greater impact on the shadow radius than increasing α, indicating that the quintessence parameter has a greater impact than the MOG parameter.
Modulation instability in nonidentical metamaterial waveguide arrays by graph Laplacian approach
Authors: Alharbi Sayer Obaid , Shafeeque Ali A K , Asma Mir , Abolaban Fouad A 
Published: April 2024

Abstract
We theoretically investigate modulation instability (MI) in a nonidentical waveguide array, which is made up of positive and negative index metamaterial waveguides. The unit cell of the optical waveguide array consists of three waveguides arranged in a triangular manner. Waveguides 1 and 3 are made up of positive index material (PIM) channels and waveguide 2 is by negative index material (NIM) channels, as a result, they show different light propagation characteristics. We model this array of waveguides using a generalized nonlinear Schro¨dinger equation, replacing the Laplacian operator with the graph Laplacian. Following linear stability analysis, we will discuss MI for different values of transverse wave number, as it determines the order of the Brillouin zone. We also discuss the effect of input power on periodic MI in normal and anomalous dispersion regimes. Thus we report a comprehensive study on the MI and hence the better ways to generate and manipulate the solitons or ultra-short pulses in NIM PIM waveguide arrays.
Effects of vacancies on quantum transport of zigzag graphene nanoribbons
Authors: Kumar Sandeep , Saklani Ritik , Bhavya  , Pratap Surender , Bhalla Pankaj 
Published: April 2024

Abstract
Using the Green’s function method, we investigate the effect of vacancies on conductance and local density of states (LDOS) in zigzag graphene nanoribbons within a symmetric and asymmetric potential wells. The results differ from ideal ribbons in that there are no conductance plateaus and a decline in conductance for varied N (number of atoms in the unit cell) and M (number of unit cells) values following vacancy incorporation. LDOS and conductance in symmetrical and asymmetrical circumstances are examined alongside vacancies and accordingly, they are affecting the respective edge states.
A novel lattice structure design approach based on Schwarz Primitive triply periodic minimal surfaces
Authors: Karamooz-Ravari M R 
Published: April 2024

Abstract
In recent years, lattice structures based on triply periodic minimal surfaces have attracted the attention of researchers worldwide due to their exceptional geometrical and mechanical features. In this paper, using two distinct implicit functions for the rotation angle and the axis of rotation, the surface points of the Schwarz’ Primitive cellular lattice are moved to a new position to construct some novel lattices. Various cellular lattices are then generated by manipulating different design parameters and investigated using finite element method to evaluate porosity, surface-to-volume ratio, elastic modulus and Zener ratio. The findings indicate that although the porosity doesn’t change profoundly by applying the transformation, the surface-to-volume ratio and elastic modulus increases and decreases respectively as the maximum rotation angle increases. In addition, Zener ratio exhibits non-linear variation with the transformation, potentially increasing or decreasing by increasing the maximum rotation angle, depending on other parameters. The maximum difference between the values of surface-to-volume ratio, elastic modulus, and Zener ratio of the novel lattices and those of the original one is 16.9% (for one case it decreases by 68.7%), 68.5%, and 45.6%, respectively. These observations suggest that the proposed method might presents significant potential for facilitating the creation of innovative shell-based lattice structures.
Multi-pellet injection into the NBI-heated phase of TJ-II plasmas
Authors: McCarthy K.J. , García-Cortés I. , Alonso J.A. , Arias-Camisón A. , Ascasíbar E. , Baciero A. , Cappa A. , Carrasco R. , Chmyga O.O. , Estrada T. , García R. , Hernández-Sánchez J. , Hernanz F.J. , Kozachok O.S. , López Miranda B. , Medina F. , Medina-Roque D. , van Milligen B. , Navarro M. , Ochando M.A. , de Pablos J.L. , Panadero N. , Pastor I. , de la Riva J. , Rodríguez M. C. , Tafalla D. , Tribaldos V. ,   TJ-II Team
Published: April 2024

Abstract
A pellet-induced enhanced confinement (PiEC) phase, with general characteristics similar to those reported for the stellarator W7-X, is observed after single pellet injection (>1019 H atoms) into the neutral beam injection heated phase of plasmas in the mid-sized heliac-type stellarator TJ-II. In addition to a step-like increase in density, plasma diamagnetic energy content rises significantly with respect to that of reference discharges, energy confinement time is similarly enhanced when compared to International Stellarator Scaling law predictions (Yamada et al 2005 Nucl. Fusion
45 1684) renormalized for TJ-II, and the triple product, n
e · T
i · τ
E, exhibits a clear bifurcation towards an improved confinement branch when compared to the branch product predicted by the same law. In this work, multiple pellets are injected in series into NBI-heated plasmas in the TJ-II and post-injection plasma performance is reported and discussed. For instance, a charge-exchange recombination spectroscopy diagnostic reveals significantly increased core ion temperatures after pellet injection compared to temperatures achieved in comparable reference plasmas, this pointing to increased ion energy content and improved ion energy confinement during a PiEC phase. It is also found that enhanced performance is independent of whether co- or counter-NBI heating beam is employed. Finally, record stored diamagnetic energy content and plasma beta values are achieved when the largest available pellets are employed. The results indicate that pellet injections extend the operational regime well beyond limits previously achieved in TJ-II without pellets.
Design and operation of a load-tolerant ICRH system in Experimental Advanced Superconducting Tokamak
Authors: Liu L.N. , Zhang X.J. , Qin C.M. , Mao Y.Z. , Yuan S. , Zhang W. , Yang H. , Wang L. , Cheng Y. , Zhang K. 
Published: April 2024

Abstract
Ion Cyclotron Resonance Heating (ICRH) has been a dependable tool for sturdy plasma heating with high RF power of several megawatts. However, a sudden increase in the reflected power during ICRH heating experiments is a problem that should be solved for future fusion experimental devices. To solve this issue, a load tolerant matching network has been designed for the ICRH system in EAST. The matching network includes a 3-stub tuner impedance matching system with conjugate-T structure, 30 Ω to 50 Ω transmission line and center grounded antenna strap. By maintaining a low reflection ratio in the network for a wide range of resistance, this matching network can allow sturdy high-power operations without fast impedance matching in EAST. In our matching network, the two arms of a conjugate-T are designed to have a

λ

/

2

length difference which could mitigate current imbalance and antenna poloidal phasing outside of the control problem. The T-point corresponds to the maximum point of the standing wave voltage, which could greatly improve the input impedance of the antenna.
Pulsed current-assisted twelve-roll precision rolling deformation of SUS304 ultra-thin strips with exceptional mechanical properties
Authors: Fan Wanwan , Wang Tao , Hou Jinxiong , Ren Zhongkai , Huang Qingxue , Wu Guanghui 
Published: April 2024

Abstract
Innovative pulsed current-assisted multi-pass rolling tests were conducted on a 12-roll mill during the rolling deformation processing of SUS304 ultra-thin strips. The results show that in the first rolling pass, the rolling reduction rate of a conventionally rolled sample (at room temperature) is 33.8%, which can be increased to 41.5% by pulsed current-assisted rolling, enabling the formation of an ultra-thin strip with a size of 67.3 μm in only one rolling pass. After three passes of pulsed current-assisted rolling, the thickness of the ultra-thin strip can be further reduced to 51.7 μm. To clearly compare the effects of a pulsed current on the microstructure and mechanical response of the ultra-thin strip, ultra-thin strips with nearly the same thickness reduction were analyzed. It was found that pulsed current can reduce the degree of work-hardening of the rolled samples by promoting dislocation detachment, reducing the density of stacking faults, inhibiting martensitic phase transformation, and shortening the total length of grain boundaries. As a result, the ductility of ultra-thin strips can be effectively restored to approximately 16.3% while maintaining a high tensile strength of 1118 MPa.Therefore, pulsed current-assisted rolling deformation shows great potential for the formation of ultra-thin strips with a combination of high strength and ductility.
Bioinspired directional structures for inhibiting wetting on super-melt-philic surfaces above 1200 °C
Authors: Wang Hujun , Zhao Xiuyuan , Xie Zhengcan , Yang Biao , Zheng Jing , Yin Kai , Zhou Zhongrong 
Published: April 2024

Abstract
Over the past two decades, superhydrophobic surfaces that are easily created have aroused considerable attention for their superior performances in various applications at room temperature. Nowadays, there is a growing demand in special fields for the development of surfaces that can resist wetting by high-temperature molten droplets (>1200 °C) using facile design and fabrication strategies. Herein, bioinspired directional structures (BDSs) were prepared on Y2O3-stabilized ZrO2 (YSZ) surfaces using femtosecond laser ablation. Benefiting from the anisotropic energy barriers, the BDSs featured with no additional modifiers showed a remarkable increase from 9.2° to 60° in the contact angle of CaO–MgO–Al2O3–SiO2 (CMAS) melt and a 70.1% reduction in the spreading area of CMAS at 1250 °C, compared with polished super-CMAS-melt-philic YSZ surfaces. Moreover, the BDSs demonstrated exceptional wetting inhibition even at 1 400 °C, with an increase from 3.3° to 31.3° in contact angle and a 67.9% decrease in spreading area. This work provides valuable insight and a facile preparation strategy for effectively inhibiting the wetting of molten droplets on super-melt-philic surfaces at extremely high temperatures.
Inflammatory, metabolic, and endothelial biomarkers before and after pregnancy complications
Authors: Sun Baiyang , Gunderson Erica P , Bertolet Marnie , Lopa Samia H , Bryan Samantha G , Lewis Cora E , Catov Janet M 
Published: April 2024

Abstract
Women with gestational diabetes mellitus (GDM), hypertensive disorders of pregnancy (HDP), and preterm birth (PTB) have excess cardiovascular disease compared with those with uncomplicated births, perhaps related to prepregnancy inflammation, dysmetabolism, or endothelial dysfunction. We included 1238 women in the Coronary Artery Risk Development in Young Adults Study (1985-2011) with 2215 births classified according to outcomes (term, uncomplicated births were the referent). Using repeated measures analysis of variance, we estimated prepregnancy and postpregnancy biomarkers, as well as biomarker change according to pregnancy outcomes, adjusted for confounders. GDM and term HDP groups had higher prepregnancy high-sensitivity C-reactive protein (hsCRP) (+0.37 [95% CI, 0.08-0.65]; +0.29 [95% CI, 0.04-0.55] log mg/L), higher leptin (+0.29 [95% CI, 0.09-0.50]; +0.37 [95% CI, 0.17-0.56] log ng/ml), and lower adiponectin (−0.25 [95% CI, −0.36 to −0.13); −0.11 [95% CI, −0.22 to −0.01] log ng/ml) values than those with uncomplicated births, and these profiles persisted in magnitude postpregnancy. Controlling for body mass index attenuated most profiles, except that lower prepregnancy adiponectin remained associated with GDM. PTB without HDP or GDM was related to lower prepregnancy hsCRP and soluble intercellular adhesion molecule-1 (−0.31 [95% CI, −0.56 to −0.06] log mg/L; −0.05 [95% CI, −0.09 to −0.01] log ng/ml) and a larger leptin increase from before to after pregnancy (+0.20 [95% CI, 0.02-0.37] log ng/ml). Prepregnancy inflammation and metabolic dysfunction contributed to GDM and HDP, perhaps due to higher body mass index. PTB may be related to adverse metabolic changes postpregnancy, although the unexpected endothelial biomarker profile warrants further study.
A call for sex-positive epidemiology
Authors: Bond Julia C , Ford Jessie V 
Published: April 2024

Abstract
The World Health Organization specifies that sexual health requires the potential for pleasurable and safe sexual experiences. Yet epidemiologic research into sexual pleasure and other positive sexual outcomes has been scant. In this commentary, we aim to support the development and adoption of sex-positive epidemiology, which we define as epidemiology that incorporates the study of pleasure and other positive features alongside sexually transmitted infections and other familiar negative outcomes. We first call epidemiologists’ attention to the potential role that stigma plays in the suppression of sex-positive research. We further describe existing measures of sex-positive constructs that may be useful in epidemiologic research. Finally, the study of sex-positive constructs is vulnerable to biases that are well-known to epidemiologists, especially selection bias, information bias, and confounding. We outline how these biases influence existing research and identify opportunities for future research. Epidemiologists have the potential to contribute a great deal to the study of sexuality by bringing their considerable methodological expertise to long-standing challenges in the field. We hope to encourage epidemiologists to broaden their sexual health research to encompass positive outcomes and pleasure.
The proposed reform of the English Arbitration Act on arbitrators’ independence and impartiality and the duty of disclosure from a comparative perspective
Authors: Lindsay Emma , Gambarini Camilla 
Published: April 2024

Abstract
The arbitrator’s obligation of independence and impartiality is one of the core principles of international arbitration that serves to ensure fairness in the resolution of disputes through private justice.1 The terms independence and impartiality are often used interchangeably,2 but they are distinct concepts. Independence relates to the relationship or links between an arbitrator and a party, whether financial or otherwise, which may be determined through an objective test. Impartiality, on the other hand, is connected with the actual or apparent bias of an arbitrator and reflects a subjective state of mind.3
Chemical and biological study of flavonoid-related plant pigment: current findings and beyond
Authors: Yoshida Kumi 
Published: April 2024

ABSTRACT
Flavonoids are polyphenolic plant constituents. Anthocyanins are flavonoid pigments found in higher plants that show a wide variety of colors ranging from red through purple to blue. The blue color of the flowers is mostly attributed to anthocyanins. However, only a few types of anthocyanidin, chromophore of anthocyanin, exist in nature, and the extracted pigments are unstable with the color fading away. Therefore, the wide range and stable nature of colors in flowers have remained a mystery for more than a century. The mechanism underlying anthocyanin-induced flower coloration was studied using an interdisciplinary method involving chemistry and biology. Furthermore, the chemical studies on flavonoid pigments in various edible plants, synthetic and biosynthetic studies on anthocyanins were conducted. The results of these studies have been outlined in this review.