bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment of neuroblastoma‐related opsoclonus–myoclonus–ataxia syndrome with high‐dose dexamethasone pulses
Authors: Ertle Florian , Behnisch Wolfgang , Al Mulla Naima Ali , Bessisso Mohammed , Rating Dietz , Mechtersheimer Gunhild , Hero Barbara , Kulozik Andreas E. 
Published: January 2007

AbstractOpsoclonus–myoclonus–ataxia‐syndrome (OMS) represents a rare neuroblastoma‐associated paraneoplastic syndrome that commonly results in neurologic deficits despite tumor resection and immunosuppressive therapy. We describe the response of five such children to high‐dose dexamethasone pulses including two patients in whom previous glucocorticoids, rituximab, and cytostatic drugs were not successful. All patients had MYCN non‐amplified tumors that were detected 1 to 7 months after the onset of the OMS or ataxia. This treatment resulted in a good partial response in three and in complete remission in two patients. Our results show that dexamethasone pulses are likely to be useful for both, first‐line‐ and salvage‐therapy for OMS‐patients. Pediatr Blood Cancer 2008;50:683–687. © 2007 Wiley‐Liss, Inc.
Cause of mortality in 5‐year survivors of childhood cancer
Authors: Mertens Ann C. 
Published: January 2007

AbstractSurvivors of childhood and adolescent cancer are at risk for long‐term effects of disease and treatment. The Childhood Cancer Survivor Study assessed overall and cause‐specific mortality in a retrospective cohort of 20,690 5‐year survivors. Eligible subjects were individuals diagnosed with cancer (from 1970 to 1986) before the age of 21 who had survived 5 years from diagnosis. Underlying cause of death was obtained from death certificates and other sources, then and coded and categorized as recurrent disease, sequel of cancer treatment, or non‐cancer‐related. Age and sex standardized mortality ratios (SMRs) were calculated using United States population mortality data. The cohort demonstrated an 8.2‐fold excess in overall mortality (95% confidence interval, 7.9 to 8.5). Recurrence of the original cancer was the leading cause of death among 5‐year survivors, accounting for 57% of deaths. Statistically significant excess mortality rates were seen due to subsequent malignancies (SMR = 15.0), along with cardiac (SMR = 6.9), and pulmonary (SMR = 8.7). There was no increase seen for automotive accidents (SMR = 1.0), other accidents (SMR = 1.3), or suicide (SMR = 1.0). While recurrent disease remains a major contributor to late mortality in 5‐year survivors of childhood cancer, significant excesses in mortality risk associated with treatment‐related complications exist up to 25 years after the initial cancer diagnosis. Pediatr Blood Cancer 2007;48:723–726. © 2007 Wiley‐Liss, Inc.
The future of pediatric cancer and complex diseases: Aren't they all?
Authors: Chanock Stephen , Yeager Meredith 
Published: January 2007

AbstractOver the past decade, the investigation of human genetics and disease has pursued both common and uncommon germ‐line variation and shown that both can be associated with altered risk for cancer and its outcomes. This line of investigation has not only begun to generate markers for disease but also insights into the biological pathways that are altered in cancer. Already, there is emerging evidence that germ‐line genetic variation can alter susceptibility to different types of cancers, including pediatric cancers. It is evident that common genetic variation has emerged as a key component of a comprehensive understanding of pediatric cancer and its outcome. Future studies should unravel the complex interaction between genes and the environment. Pediatr Blood Cancer 2007;48:719–722. © 2007 Wiley‐Liss, Inc.
Interstitial brachytherapy for childhood soft tissue sarcoma
Authors: Laskar Siddhartha , Bahl Gaurav , Ann Muckaden Mary , Puri Ajay , Agarwal Manish G. , Patil Nikhilesh , Shrivastava Shyam K. , Dinshaw Ketayun A. 
Published: January 2007

AbstractBackgroundTo evaluate the efficacy of interstitial brachytherapy (BRT) in children undergoing combined modality treatment for soft tissue sarcomas (STS).ProcedureFrom September 1984 to December 2003, 50 children (median age 13 years, range 1 to 18) with STS who received BRT as part of loco‐regional treatment were included. There were 30 males and 20 females, the majority (68%) had primary lesions, synovial sarcoma (32%) was the most common histological type, and 26% had high‐grade lesions. Treatment included wide local excision and BRT with or without external beam radiotherapy (EBRT). Thirty children (60%) received BRT alone.ResultsAfter a median follow‐up of 51 months, the local control (LC), disease‐free survival, and overall survival were 82%, 68%, and 71%, respectively. LC was superior in patients with tumor size ≤5 cm versus >5 cm (96% vs. 67%, P = 0.04), symptom duration <2 months versus >2 months (100% vs. 73%, P = 0.05), and Grade I versus Grade II versus Grade III tumors (100% vs. 93% vs. 57%, P = 0.03). Children receiving a combination of BRT and EBRT had comparable LC to those receiving BRT alone (78% vs. 84%, P = 0.89). There was no significant difference in LC for patients receiving LDR versus HDR BRT (77% vs. 92%, P = 0.32, for BRT alone; and 67% vs. 100%, P = 0.17, for BRT + EBRT).ConclusionInterstitial BRT with or without EBRT appears to result in satisfactory outcome in children with STS. Radical BRT alone, when used judiciously in select groups of children, results in excellent local control and functional outcome with reduced treatment‐related morbidity. Pediatr Blood Cancer 2007;49:649–655. © 2007 Wiley‐Liss, Inc.
A pilot intervention to enhance psychosexual development in adolescents and young adults with cancer
Authors: Canada Andrea L. , Schover Leslie R. , Li Yisheng 
Published: January 2007

AbstractBackgroundEvidence suggests that cancer diagnosed during adolescence and young adulthood may present considerable challenges to what would otherwise be a relatively smooth developmental trajectory, particularly in areas related to reproductive health. We created and pilot tested a two‐session, individually‐delivered, counseling intervention to enhance psychosexual development in this unique population.ProceduresA total of 21 patients, aged 15 to 25 years and treated for cancer within the past 5 years, completed the counseling intervention. Patients were adaptively randomized to begin the intervention immediately, or to be placed on a 3‐month waitlist, after which time, they were reassessed and began the intervention. The content of the intervention included education, dialog, and support regarding cancer and such issues as sexual development and function, body image, fertility, prevention of sexually transmitted disease and unwanted pregnancy, and romantic relationships (e.g., dating, sexual communication). A 1‐month follow‐up booster call followed the intervention. Questionnaires were completed at baseline, post‐waitlist (for half the sample), post‐treatment, and at 3‐month follow‐up.ResultsParticipation in the intervention increased cancer‐specific knowledge regarding sexual issues; improved body image; lessened anxiety about sexual and romantic relationships; and decreased overall level of psychological distress. Gains were maintained through the 3‐month follow‐up.ConclusionsAddressing issues of reproductive health in the adolescent/young adult with cancer can and should be offered as a part of comprehensive pediatric cancer care. Pediatr Blood Cancer 2007;49:824–828. © 2007 Wiley‐Liss, Inc.
Treatment of recurrent clear cell sarcoma of the kidney with brain metastasis
Authors: Radulescu Vlad C. , Gerrard Mary , Moertel Chris , Grundy Paul E. , Mathias Liesl , Feusner James , Diller Lisa , Dome Jeffrey S. 
Published: January 2007

AbstractBackgroundClear cell sarcoma of the kidney (CCSK) is known for its propensity to metastasize to bone, but it also spreads to other sites including the brain. This study was undertaken to describe the treatment and outcomes of patients with recurrent CCSK involving the brain.MethodsA retrospective records review was conducted on eight patients with CCSK who developed brain metastases after complete responses to initial therapy.ResultsThe recurrences occurred at a median of 24.5 months after initial diagnosis (range, 12–53 months). At the time of recurrence, patients were treated with multimodal therapy including biopsy or resection, radiation therapy, and chemotherapy. All patients received a variable number of courses of ifosfamide, carboplatin, and etoposide (ICE), with or without other agents. Four patients received high‐dose chemotherapy with autologous stem cell rescue. One patient died from complications of bacteremia 8 weeks after starting chemotherapy. The other seven patients achieved a complete response after either surgery or ICE chemotherapy. Of these, six patients were alive without disease with a median follow‐up of 30 months from the time of recurrence (range, 24 to 71 months). All six survivors received radiation therapy and four had gross total resections. Three survivors received high‐dose chemotherapy with stem cell rescue.ConclusionPatients with recurrent CCSK involving the brain can have durable survival after recurrence. ICE chemotherapy, together with radiation therapy and surgery, provides a reasonable salvage regimen for recurrent CCSK. It is unclear whether high‐dose chemotherapy confers a benefit compared to conventional‐dose chemotherapy. Pediatr Blood Cancer 2008;50:246–249. © 2007 Wiley‐Liss, Inc.
Oral anticoagulation with warfarin is significantly influenced by steroids and CYP2C9 polymorphisms in children with cancer
Authors: Ruud Ellen , Holmstrøm Henrik , Bergan Stein , Wesenberg Finn 
Published: January 2007

AbstractClinical management of warfarin therapy is complex, and dosing algorithms do not include genetic factors or interactions with other drugs for warfarin dose determinations. We evaluated the interaction of warfarin and CYP2C9 polymorphisms and concomitant corticosteroids in 29 children with cancer. Children with heterozygous polymorphisms of CYP2C9 achieved target INR sooner and more frequently had INR above the target level, compared to children without mutations. Children on concomitant steroids had significantly lower warfarin requirements. Thus, awareness of CYP2C9 genotype and steroid‐induced responsiveness to warfarin may be important when administrating oral anticoagulation in children. Pediatr Blood Cancer 2008;50:710–713. © 2007 Wiley‐Liss, Inc.
Microdielectric analysis and curing kinetics of an epoxy resin system
Authors: Chen Jihua , Hojjati Mehdi 
Published: January 2007

AbstractMicrodielectric analysis (DEA) was carried out to investigate the cure behavior of a bisphenol F epoxy/aromatic amine resin system using an online dielectric cure monitoring technique. Ionic conductivity measured by a microdielectric sensor under isothermal conditions was correlated to the degree of cure and glass‐transition temperature, which are determined by differential scanning calorimetry (DSC). Results obtained by isothermal DSC measurement were used to establish a cure kinetic model for the epoxy resin. Experimental results show that the ratio of the ion conductivity to the initial ion conductivity, Logσ/Logσ0, has a linear relation with the glass‐transition temperature. Furthermore, correlations between ion conductivity and degree of cure and cure rate are established using the best fit of the measured data. Cure behavior of the epoxy resin obtained by DEA is compared with that predicted by the cure kinetics model. Good agreement was observed. POLYM. ENG. SCI., 47:150–158, 2007. © 2007 Society of Plastics Engineers
An experimental study of slip flow in capillaries and semihyperbolically converging dies
Authors: Kamerkar P.A. , Edwards B.J. 
Published: January 2007

AbstractSlip velocity is measured in straight‐walled capillary dies and semihyperbolically converging dies (SHCDs) in three industrial polymer melts, with and without the presence of a viscosity reducing stearic acid (SA) additive. Data taken in shear flow through capillary dies indicated a substantial increase in the slip velocity caused by the addition of the SA. Data taken in the SHCDs showed much less of an increase in the slip velocity of the polymer/additive system relevant to the neat polymer. One possible explanation of this observation is that the magnitude of the slip velocity is directly related to the degree of orientation within the flowing polymeric material. POLYM. ENG. SCI., 47:159–167, 2007. © 2007 Society of Plastics Engineers
Photopolymerization of ternary thiol–ene/acrylate systems: Film and network properties
Authors: Wei Huanyu , Senyurt Askim F. , Jönsson Sonny , Hoyle Charles E. 
Published: January 2007

AbstractPhotocurable, ternary‐component mixtures of a 1:1 molar multifunctional thiol–ene (trithiol and triallyl ether) blend and a 16‐functional acrylate based monomer have been photopolymerized, and the final film properties of the ternary crosslinked networks have been measured. The photopolymerization kinetics, morphology, and mechanical and physical properties of the films have been investigated with real‐time infrared, atomic force microscopy, and dynamic mechanical analysis. The photopolymerization process is a combination of acrylate homopolymerization and copolymerizations of thiol with allyl ether and acrylate functionalities. The tan δ peaks of the photopolymerized ternary systems are relatively narrow and tunable over a large temperature range. The morphology is characterized by a distinct phase‐separated nanostructure. The photocured thiol–ene/acrylate ternary systems can be made to exhibit good mechanical properties with enhanced energy absorption at room temperature by the appropriate selection of each component concentration. © 2007 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 45: 822–829, 2007.
Synthesis of optically active polymers containing chiral phosphorus atoms in the main chain
Authors: Morisaki Yasuhiro , Ouchi Yuko , Tsurui Kazuhiko , Chujo Yoshiki 
Published: January 2007

AbstractWe successfully synthesized optically active polymers by using a chiral bisphosphine, (S,S)‐1,2‐bis[boranato(t‐butyl)methylphosphino]ethane, as a key building block. Their structures were characterized with 1H, 13C, and 31P NMR spectra. The obtained polymers exhibited different glass‐transition temperatures depending on the structure of each comonomer, whereas a model compound had a melting point. According to circular dichroism spectra, the difference in the stereochemistry of the comonomers yielded the different higher‐ordered structures of the polymers induced by chiral phosphine units. © 2007 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 45: 866–872, 2007
Preparation of thermosetting polyurethane nanocomposites by montmorillonite modified with a novel intercalation agent
Authors: Wang Jin‐Cheng , Chen Yue‐Hui , Chen Ren‐Jie 
Published: January 2007

AbstractA novel thermosetting polyurethane (TSPU)/organic montmorillonite (OMMT) nanocomposite has been synthesized. N‐diamino octadecyl trimethyl ammonium chloride (DODTMAC) was used as an intercalation agent to treat Na+‐montmorillonite (MMT) and form a novel kind of OMMT. Fourier transform infrared spectroscopy (FT‐IR), wide angle X‐ray diffraction (WAXD), and thermogravimetric analysis (TGA) data indicated that the MMT was successfully intercalated by this intercalation agent, as evidenced by the fact that the basal spacing of MMT galleries was expanded from 1.5 to 3.2 nm. This OMMT was used to prepare the TSPU nanocomposites. Both the reinforcing and compatibilizing performance of the filler were investigated. Tensile tests showed that the tensile strength of TSPU/OMMT‐4 was the highest, and was about 3.62 times higher than that of the pure TSPU, and also the elongation at break showed an enhancement. Differential scanning calorimetry (DSC) and dynamic mechanical analysis (DMA) measurements illustrated that the glass transition temperature of the TSPU/OMMT‐4 nanocomposite was improved from 0.5 to 6.5 °C, which corresponded to the restriction of the soft segments of TSPU. The highest initial and center temperatures of TSPU/OMMT‐4 obtained from TGA were due to the highest retard effect of the TSPU molecular chains. WAXD studies showed that the formation of the nanocomposites in all the cases with the almost disappearance of the peaks corresponding to the basal spacing of MMT. SEM and TEM were used to investigate the morphologies of the TSPU/OMMT‐4 nanocomposite, and demonstrated that the nanocomposite was comprised of a well dispersion of a mixture of intercalated and exfoliated silicate layers throughout the matrix. It was proposed that the nano‐reinforcing effect caused by the well‐dispersed silicate layers might reduce the amount and size of voids and increase the length of the crack‐spreading path during tensile drawing. © 2007 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 45: 519–531, 2007.
Ferroelectric BaTiO3 nanoceramics prepared by a three‐step high‐pressure sintering method
Authors: Xiao C. J. , Zhang W. W. , Chi Z. H. , Li F. Y. , Feng S. M. , Jin C. Q. , Wang X. H. , Li L. T. , Chen R. Z. 
Published: January 2007

AbstractDense BaTiO3 nanoceramics with a homogeneous grain size of 30 nm were prepared at 6 GPa, 1000 °C using a three‐step high‐pressure sintering method. The microstructure of the ceramics obtained is uniform and the relative density is above 98% of the theoretical value. Similar to normal BaTiO3 ceramics, successive phase transitions are observed in the 30 nm BaTiO3 ceramics using variable‐temperature X‐ray diffraction measurements. Furthermore the 30 nm BaTiO3 ceramics reveal ferroelectric properties after being post‐annealed at low temperature in O2 atmosphere, but the phase transition temperature from paraelectric to ferroelectric phase is 10 °C lower than that of a normal bulk sample. The results indicate that dense 30 nm BaTiO3 ceramics retain ferroelectricity above room temperature. (© 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Comment on “ESR study of Sr‐doped LaCoO3 cobaltites” [phys. stat. sol. (b) 242, No. 7, 1522–1527 (2005)]
Authors: Rozenberg E. 
Published: January 2007

AbstractNumerous uncertainties, discrepancies and obscurities are characteristic of both the experimental data and its interpretation presented in the paper by Phan et al. [phys. stat. sol. (b) 242, 1522 (2005)]. The main features of these are mentioned and discussed in this Comment. (© 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Electronic structures and spectra of porphyrin with fused benzoheterocycles: DFT and TDDFT‐PCM investigations
Authors: Zhu Yulan , Zhou Shuyu , Kan Yuhe , Su Zhongmin 
Published: January 2007

AbstractDensity functional theory (DFT) and time‐dependent DFT (TDDFT) are applied to study seven asymmetric π‐conjugated porphyrins with extended benzoheterocycles: quinoline, indole, benzoimidazole, benzothiazole, benzooxazole, 2,1,3‐benzothiadiazole, and 2,1,3‐benzoxadiazole. The solvation effects on the excitation energies for these porphyrin derivatives in chloroform are taken into account by using the continuum model (C‐PCM) combined with TDDFT, and this method makes a closer agreement with the experimental values, especially for the B‐bands of these objects. Great efforts have been made on investigating the influences of the fused aromatic units of the porphyrins on the absorption properties as these can be particularly important for many applications. Benzoheterocycle introduction and solvent effects have been systemically investigated, and close agreement is obtained between calculated and measured UV–vis spectra. These theoretical data could shed light on future synthetic chemistry. © 2007 Wiley Periodicals, Inc. Int J Quantum Chem, 2007
New lower bound formula from the local energy
Authors: Marmorino M. G. 
Published: January 2007

AbstractA new formula to determine a lower bound to the ground‐state energy of an electronic system is presented making use of the local energy. Two‐electron atoms are considered and each lower bound is not only superior to the traditional lower bound, which is just the minimum of the local energy, but is also closer to the exact energy than the Hamiltonian expectation value that uses the same trial function. In this method, we have removed the restriction that the trial function be non‐zero. Lower bound methods using the local energy have the advantage that the expectation value of the squared Hamiltonian or another potentially difficult integral does not have to be calculated as in many other lower bound methods. © 2007 Wiley Periodicals, Inc. Int J Quantum Chem, 2007
Ring opening of boriranes vis‐à‐vis aziridines: An ab initio and DFT probe on the mechanisms
Authors: Kalaiselvan Anbarasan , Venuvanalingam Ponnambalam 
Published: January 2007

AbstractBorirane undergoes ring opening reaction with NOCl and HNF2 yielding the corresponding alkenes. Ab initio and density functional investigations of this reaction with cis‐ and trans‐2,3‐dimethylboriranes reveal that these reactions take place in a single step through the formation of a prereactive complex and a transition state giving the alkene with the same stereochemistry. Calculations clearly show that the concerted cleavage of CB bonds leads to retention of stereochemistry. Further, it shows that HNF2 cleaves boriranes more efficiently than does NOCl. Intrinsic reaction coordinate analyses and bond order analysis describe the nature of the transition state very well and fix the reaction mechanism. Solvent effect calculations through PCM model, with acetonitrile and CCl4 as solvents, do not alter the gas phase results significantly. © 2007 Wiley Periodicals, Inc. Int J Quantum Chem, 2007
Use of survey and clinical data for screening and diagnosis
Authors: Chetty V. K. , Bruce Zellner B. 
Published: January 2007

AbstractBackground: U.S. prevalence of diabetes in 2005 was 20.8 million people (6.2 million undiagnosed) (Diabetes Statistics. 2006). Recognizable preclinical stage is between 7 and 12 years. Efficient screening and early diagnosis can help: 1. avoid or delay development of diabetes. 2. treat early and avoid co‐morbidities.Design: Retrospective cross‐sectional study of 153 113 adults ages 24 to 83 from the Behavioural Risk Factor Surveillance Systems (BRFSS)—2003 of whom 4379 had diabetes at their current age or during the previous year and 2190 adults ages 40 to 74 from the National Health and Nutrition Examination Survey III, 211 of whom had glucose tolerance test result ⩾ 200 mg/dL.Objectives: To develop statistical models for screening and diagnosis.Methods: Logistic and generalized linear and additive regression models, Akaike information criterion, area under the receiver operating characteristic (ROC) curve, Bayes rule.Results: Area under the ‘productivity’ curve using BRFSS data is 0.65 indicating an average yield of 17.3 per cent. Survey data is useful also for diagnosis. Area under the ROC curve (AUC) using only survey data is 0.68. AUC for fasting plasma glucose (FPG) alone is 0.91. Stepwise drop one method of selecting co‐variates for diagnosis included pre‐test probability from BRFSS. When both FPG and pre‐test information are included, AUC increases to 0.93. Reduction in residual deviance and 0.02 increase in AUC are statistically significant (p = 0.0012). Clinical significance of prior odds is shown by increase in accuracy and weighted average of sensitivity and specificity. Empirically estimated regression weights for pre‐test and test information vary with age and race and are not equal, as required by Baye's theorem. Overfitting index was less than 1 per cent.Conclusions: Cross‐section surveys are useful for increasing screening efficiency and diagnostic accuracy. Copyright © 2007 John Wiley & Sons, Ltd.