bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhancing Preoperative Planning in Tibial Plateau Fractures: A Comparative Study of 3D Printing's Impact on Surgical Decision-Making
Authors: Dust Tobias , Henneberg Julian-Elias , Hartel Maximilian J. , Korthaus Alexander , Ballhause Tobias , von Rehlingen-Prinz Fidelius , Streckenbach Anna , Keller Johannes , Frosch Karl-Heinz , Krause Matthias 
Published: April 2024

Abstract
Background: Treatment of complex tibial plateau fractures remains a challenging task in clinical practice. Sufficient and appropriate preoperative decision making is essential for optimal treatment success and ultimately influences patient outcomes. Recently, the novel technique of 3D printing has proven to be beneficial for the preoperative management in other joint regions.
Methods: To investigate the impact of point-of-care 3D printing on the preoperative management of tibial plateau fractures, we asked 5 students, 10 surgical residents, 3 junior surgeons and 5 senior surgeons, to simulate the preoperative planning of 22 tibial plateau fractures (11 AO B and 11 AO C fractures) regarding the treatment concept, patient positioning, operative approach and implant selection and positioning. First with CT scans only, second with 3D volumetric reconstructions, and finally with 3D printed fracture models. We analyzed the inter- and intraobserver agreement and the subjective perceived confidence of the rater regarding his decision with the different imaging modalities across the different levels of professional experience. Statistics were performed using kappa values, percentage match (PM) analysis and a univariate one-way analysis of variance.
Results: The use of 3D printing had no effect on the interobserver reliability of treatment concept selection (PM CT 83% > 3DCT 83% > 3D 82%). However, kappa and percentage match values increased for agreement on patient positioning (k CT 0.25 > 3DCT 0.26 > 3D 0.36; PM CT 46% > 3DCT 36% > 3D 53%) and surgical approach (k CT 0.23 > 3DCT 0.22 > 3D 0.27; PM CT 29% > 3DCT 29% > 3D 33%). In addition, the raters selected the implants that were actually used to treat the fractures in 63% of the cases. The subjective perceived certainty of the raters increased with the use of 3D printing technology from 45% (CT and 3DCT) to 60% (3D). Additionally, raters changed their treatment plan in 36% of the cases and gained additional information 76% of the time when using the 3D printed specimen.
Conclusion: The use of 3D printed fracture models provides a relevant benefit for the preoperative management of tibial plateau fractures. Even experienced surgeons benefit from the haptic impression of the 3D model.
Level of evidence: Level II
Assessment of abdominal aortic elasticity and its relationship with blood pressure in dogs at different stages of degenerative mitral disease
Authors: Buriticá-Gaviria Edwin , Echeverry-Bonilla Diego , Naranjo-Medellín Miguel , Ruviano-Tuleski Giovana , Gonçalves-Sousa Marlos 
Published: April 2024

Abstract
High blood pressure is a common clinical condition in veterinary medical practice, and its identification can occasionally present a diagnostic challenge. The use of ultrasound has made it possible to adopt a diagnostic complementary approach to this condition by evaluating abdominal aortic elasticity (AAE). The aim was to check if AAE can help monitor and screen dogs with mitral valve regurgitation at different stages and identify a cut-off value to determine hypertension in these dogs. A total of 35 dogs of different breeds, with an average body weight (BW) of 6,8±3,9 kg, and 10,7±4,4 years on average, were evaluated in a prospective, randomized blind study. The animals were divided into three groups: group 1 (control, n = 8), group 2 (B2 stage, n = 19), and group 3 (C or D stage, n = 8), according to the evidence or not of heart murmur in the left apex, evidence or not of clinical signs, changes in the thickness of the mitral leaflet, left atrium/aorta ratio (LA/Ao) and normalized left ventricular diastolic diameter (NLVDD). The average AAE in the animals of group 1, group 2, and group 3 was 11,4±5,3%; 8,4±3,8% y 7,2±3,9% respectively, without statistically significant difference between them. An inverse correlation of 73,5% (p<0,001) was evidenced between the AAE value measured by abdominal ultrasonography and the systolic blood pressure measured by oscillometry. AAE value ≤6,1% was a discriminator of arterial hypertension in dogs with mitral valve regurgitation at a sensitivity of 80,0% and a specificity of 75,6%. The results of this study suggest that ultrasonographic measurement of AAE could be helpful in monitoring, screening, and identifying hypertension in dogs with mitral valve regurgitation or different stages of congestive heart disease; However, given its moderate sensitivity, more studies are suggested to support this statement.
Sound intensities between 40 dB and 50 dB are suitable for acoustic-cued water maze tests
Authors: Han Xiaodong , Fu Zhaoying , Jiang Yanna , Zhang Zhe , Gao Cheng , Wu Shuai , Chen Meini 
Published: April 2024

Abstract
We carried out an acoustic-cued water maze experiment at three sound intensity levels (30 dB, 40 dB, and 50 dB) in 30 mice (10 per group), aiming to determine the sound intensity suitable for an acoustic-cued water maze. The results showed that sound intensities at both 40 dB and 50 dB were effective in terms of the escape latency, the first crossing, the crossing number, and the quadrant time, and the effectiveness of both were about the same. On the other hand, a sound intensity of 30 dB was not as effective because there was no statistically significant improvement in escape latency across training days. Therefore, we consider sound intensities between 40 dB and 50 dB to be suitable for acoustic-cued water maze tests.
Integration of freeze-drying and Lugol-enhanced µCT imaging in virtual meniscus modelling for 3D printing and FE analysis
Authors: Moser Anna-Christina , Fritz Jennifer , Otahal Alexander , Kesselring Andreas , Schüssler Florian , Eisner Patrick , Schneider Karl , Teuschl Andreas , Reissig Lukas , Zopf Lydia , Nehrer Stefan 
Published: April 2024

Abstract
The knee menisci maintain stability and function of a healthy knee joint. Therefore, degenerative, or traumatic meniscus injuries may require meniscal implants to restore function. The aim of this study was to create a 3D-printable meniscus implant that emphasizes the representation of circumferential collagen fibres for biomechanical function. A novel Lugol-staining and freeze-drying technique was developed to prepare six human menisci for analysis of circumferential fibre volume proportion using μCT scans. Average volumes of 46.09% and 50.23% were observed in the medial and lateral meniscus, respectively. The resulting STL file, generated with UltiMaker Cura, had a circumferential infill structure occupying 48% of the total volume. A Python script was developed to extract coordinates from the G-code, facilitating the conversion of complex STL geometries into detailed volumetric finite element models (FEMs). These FEMs allow adjustment of volume proportions and outer layer thicknesses for finite element analysis (FEA), enabling virtual simulations to assess biomechanical properties and modify designs prior to implant manufacture. This methodology represents a promising avenue for advances in orthopaedic tissue engineering employing 3D-printing approaches.
Clinical features of vascular involvement in paediatric Behçet's syndrome: A retrospective, multi-center study
Authors: Li Ming , Zhao Xue , Wang Lian , Kang Min , Zhang Dan , Xu Yingjie , Zhu Jia , Su Gaixiu , Lai Jianming 
Published: April 2024

Abstract
Objective: Behçet’s syndrome (BS) can affect the vascular system, but little is known about the clinical manifestations of vasculo-BS (VBS) in children. The aim of this study was to explore the clinical characteristics of paediatric VBS.
Methods: Clinical data of children with VBS treated at the Children's[A1] Hospital affiliated with the Capital Institute of Pediatrics and its sister hospitals from March 2013 to April 2023 were retrospectively analysed.
Results: A total of 12 cases were identified, including 5 males and 7 females. Among them, 10 cases (83.3%) were treated at our department, accounting for 21.2% of the total BS cases in our department. The median age of onset was 9.5 years (range: 3-13 years). Vascular lesions were detected at the time of diagnosis in 10 cases, including 8 cases of pure arterial involvement ,2cases of pure venous involvementand and 2 cases of both arterial and venous involvement. Commonly affected arteries included the lower limb arteries (4/12), pulmonary artery, subclavian artery, renal artery, and superior mesenteric artery (3/12 each). Arterial wall thickening (6/12) and luminal stenosis (5/12) were common arterial lesions, with pulmonary artery thrombosis and arterial occlusion reported in 2 cases each. Venous wall thickening and luminal stenosis (2/12), as well as thrombosis (2/12), were common venous lesions, with superficial or deep venous thrombosis observed. Twelve cases received steroid therapy, 9 cases were treated using steroids combined with cyclophosphamide, and 8 cases were treated using steroids combined with thalidomide, while 9 cases using steroids combined with biologic agents. Surgical treatment was performed in 4 cases. Eight cases remained stable, 2 cases had recurrent activity, and 1 case died suddenly from cardiac causes.
Conclusion: Paediatric VBS is rare, and vascular lesions are often identified concurrently with the diagnosis of BS. Arterial involvement is more common than venous involvement. Commonly affected arteries include the lower limb arteries, pulmonary artery, subclavian artery, renal artery, and superior mesenteric artery. Vascular lesions typically manifest as vascularwall thickening and/or luminal stenosis, with complications such as pulmonary artery embolism, arterial aneurysms, arterial occlusion, and venous thrombosis. Treatment with steroids combined with immunosuppressive agents and biologic agents is effective, but some cases still have a poor prognosis.
A comparative study of geotechnical parameters of vindhyan sandstone
Authors: KUMAR SAURABH , Pandey Hemant Kumar , Chaudhary Videshi 
Published: April 2024

Abstract

The strength of the rock is a very important concern to use in construction of civil engineering projects The utilization of rock in building construction is much dependent on their strength, weathering and aesthetic values. The uniaxial compressive strength (UCS) is a handy parameter for geotechnical studies. In paper, the physical strength tests were performed in the laboratory and a correlation was developed between these tests (the uniaxial compressive strength (UCS) value with Slake Durability Index (SDI), point load index strength (PLIS), and Brazilian tensile strength (BTS)).The relationship is quite nonlinear. A relationship also developed for water absorption (WA) and SDI for sandstone. The relation of WA and SDI is very linear in inverse direction which shows that the water plays the major role for degradation of rock. A comparative study of the results obtained from the study area with the previous studies to understand the relationship phenomena for sandstone. The previous studies result also justifies the relationship of UCS with PLIS, BTS, and SDI. The results show that the strength of intact rock is highly variable and suitable for construction work. The comparative study shows almost similar results for sandstone.
Common bean processing to obtain an unconventional protein ingredient for the food industry
Authors: Lima Janice Ribeiro , Azevedo Tatiana de Lima , Galdeano Melicia Cintia , Felberg Ilana , Mellinger Caroline Grassi 
Published: April 2024

Abstract

Common beans are cultivated worldwide and can be considered as raw material for obtaining protein ingredients for novel products development, especially for the plant-based food market. They are naturally rich sources of proteins, ranging from 19 to 24%. Parameters for alkaline extraction (pH, solid to water ratio, and stirring time) and acid precipitation (pH and stirring time) of proteins from common beans were defined. Four scaling-up tests were performed to validate the selected parameters. Results showed that the process should follow a protein water extraction step (water and bean flour ratio of 1:8, pH of 9.0, and 30 minutes stirring) followed by an acid precipitation step (pH of 5.5 and 10 minutes stirring), and spray drying. The protein concentrate obtained is a powder with 76.5% protein on a dry basis and the process presented mass yield of 11.0% and protein yield of 39.7%. The common bean protein concentrate obtained can be used as an ingredient to enhance protein content in food formulations.
Early warning of complex climate risk with integrated artificial intelligence
Authors: Reichstein Markus , Frank Dorothea , Benson Vitus , Camps-Valls Gustau , Denzler Joachim , Kornhuber Kai , Schoelkopf Bernhard , Vinuesa Ricardo , Han Boran , Fearnley Carina , Rahaman Nasim , Tarraga José María , Blunk Jan , Dall Karen , Martini Giulia , Nganga Naomi , Robinson Danielle 
Published: April 2024

Abstract

As our climate undergoes significant shifts, both the Earth and human societies are increasingly exposed to disasters and stress. This situation underscores the critical need for robust Early Warning Systems (EWS), which are intricately designed to monitor, assess, and relay information about impending risks and hazards. EWS are vital in promoting resilient and sustainable development, yet they encounter substantial challenges in forecasting hazards and impacts, communicating risks, and in the efficiency of decision-making processes. In this perspective, we examine these challenges and explore the transformative role of integrated Artificial Intelligence Foundation Models (AI FMs), especially focusing on the capabilities of Large Multi-Modal Models (LMMs). We discuss the power of these models in developing a Multi-Hazard Early Warning System (MHEWS), combining Meteorological and Geospatial FMs for impact prediction in a comprehensive approach. Emphasizing a user-centric strategy, this paper highlights the importance of intuitive interfaces and incorporating community feedback to enhance crisis management. Given the complex nature of climate risks, we emphasize the need for causal representations in AI models, to avoid conclusions and predictions based on spurious correlations. Additionally, we introduce the concept of decadal EWSs, which aims to provide longer term, yet spatially resolved forecasts. By leveraging climate ensembles and generative approaches, these advancements aim to provide proactive solutions for evolving climate dynamics and societal responses.
Incidence of invasive breast cancer in women treated with testosterone implants: Dayton prospective cohort study, 15-year update
Authors: Glaser Rebecca L. , Dimitrakakis Constantine , Gindri Izabelle M , Pizzolatti André L , Pinto Luiz Paulo S , Glaser-Garbrick Daniel 
Published: April 2024

Abstract
Background: We previously published 10-year results (from March 2008-March 2018) from the Dayton prospective breast cancer prevention study, which showed a 40% reduction in the incidence of invasive breast cancer in women receiving testosterone or testosterone with anastrozole implant therapy compared to the age-matched Surveillance Epidemiology and End Results (SEER) expected incidence rate. We continued to follow the study subjects on therapy through March 2023.
Methods: This 10-year prospective cohort study was approved in March 2008, at which time recruitment was initiated. Recruitment was closed in March 2013. Pre- and postmenopausal women who received at least two pellet insertions were eligible for analysis (n=1267). Breast cancer incidence rates are reported as an unadjusted, unweighted value of newly diagnosed cases divided by the sum of the person-time of observation for the at-risk population. The incidence rates on testosterone therapy were compared to age-specific SEER incidence rates and expected local Montgomery County incidence rates (the location of most study patients).
Results: As of March 1, 2023, a total of 16 (versus 30 expected) eligible patients were diagnosed with invasive breast cancer within 240 days of their last testosterone pellet insert equating to an incidence rate of 189/100000 p-y, which is significantly less than the national SEER expected incidence rate of 355/100000, i.e., a 47% reduction. Interestingly, local incidence rates in Montgomery County are higher than US national averages.
Conclusion: The 15-year follow-up data revealed a reduced incidence of invasive breast cancer with long-term testosterone or testosterone combined with anastrozole implant therapy. Because of the increased incidence of invasive breast cancer in our area, the amount of reduction (benefit) from testosterone therapy may be underestimated using national data/statistics for comparison.
Formation and changing principle of the dynamic shape of the pitch polishing lap under the loading conditioner in continuous polishing
Authors: Liao Defeng , Xie Ruiqing , Zhang Mingzhuang , Zhao Shijie 
Published: April 2024

Abstract
Full-aperture continuous polishing is one of the key processes for polishing large flat optical elements. The surface figure of the optics polished by continuous polishing depends largely on the pitch polishing lap’s surface shape, which is controlled by a large conditioner. The changing process of the surface shape of the viscoelastic pitch lap under the loading conditioner is extremely complicated and has not been fully understood. This paper focuses on the formation mechanism and changing principle of the dynamic shape of the pitch lap during polishing. Firstly, the viscoelastic properties of the pitch lap are analyzed, and a viscoelastic creep model of the pitch lap is established. Then, the dynamic change process of the surface shape of the pitch lap under the loading pressure of the conditioner is explored, and a solution model of the dynamic shape of the pitch lap at the polishing station is established. Finally, polishing experiments were conducted to verify the model. This paper for the first time reveals that the surface shape of the pitch lap presents a dynamic change, which lays a foundation for controlling the surface shape of the pitch lap.
Addressing class-imbalanced classification problems by triangular region pre-sampling and a differential evolution resampling
Authors: Li Min , Wang Yong , Deng Shaobo , Wang Lei 
Published: April 2024

Abstract

The problem of imbalanced data classification is a prominent and challenging research topic in the field of data mining and machine learning. Numerous studies have demonstrated that synthetic minority oversampling technique (SMOTE) and its variants are widely adopted methods for addressing imbalanced data training. However, the performance of SMOTE and its variants can be affected by noise. Additionally, most existing techniques used to handle noise in SMOTE variants involve directly deleting noisy samples, which may lead to class re-imbalance and deviation of the decision boundary. Furthermore, SMOTE and its variants do not guarantee the diversity of synthetic samples. Motivated by these limitations, this study aims to propose a novel oversampling method named TRPS-DER to tackle class-imbalanced classification problems. TRPS-DER utilizes triangular region pre-sampling for synthesizing minority class samples and employs differential evolution resampling for filtering out noise. The primary advantage of TRPS-DER include that (a) it generates minority class samples by interpolation of triangular region, thereby augmenting diversity of synthesize samples; and (b) it employs differential evolution for resampling generated samples, effectively filtering out noise and improving classification performance. Extensive experimental results demonstrate that TRPS-DER significantly outperforms other competitive SMOTE-based oversampling methods across 24 imbalanced datasets in terms of Gmean, BACC, AUC.
Laser Debonding of ultrathin occlusal veneers fabricated from different CAD/CAM ceramic materials.
Authors: Sheikh Nourhan El , Sattar Ghada Abdel , Wahsh Marwa 
Published: April 2024

Abstract
Background
Erbium lasers were used to debond restorations safely offering the possibility of their re-use. Since these lasers have a high affinity for water molecules, they are absorbed by resin cement explosive ablation of the cement and thus the restoration debonds. The efficiency of this process depends on many factors including the ceramic type, its chemical composition and thickness. Therefore, this study was designed to test the time taken to debond ultrathin occlusal veneers made of three types of milled ceramic materials and evaluate the integrity of these restorations after debonding.
Methods
three ceramic types were evaluated in this study: Lithium disilicate (IPS Emax CAD), Highly condensed lithium disilicate (GC initial®LiSi), and translucent zirconia (Katana zirconia STML). Each group consisted of 8 occlusal veneers of 0.5 mm thickness. Samples were cemented to the occlusal surfaces of upper molar teeth. Er;Cr:YSGG laser was applied to the occlusal veneers using the scanning method and time was calculated till debonding. The debonded samples were then inspected under a stereo microscope for possible damage. Numerical data were presented as mean with 95% confidence intervals (CI), standard deviation (SD), minimum (min.) and maximum (max.) values. Normality and variance homogeneity assumptions were confirmed using Shapiro-Wilk's and Levene's tests respectively. Data were normally distributed and were analyzed using one-way ANOVA followed by Tukey's post hoc test. The significance level was set at p < 0.05 within all tests. Statistical analysis was performed with R statistical analysis software version 4.3.2 for Windows[1].
Results
There was no significant difference in debonding time between different materials (p = 0.995). The longest debonding time was found in Katana STML (87.52 ± 20.45) (seconds), followed by Emax (86.94 ± 20.63) (seconds), while the lowest value was found at LiSi initial (86.14 ± 25.16) (seconds). In terms of damage to the debonded veneers, The Emax and zirconia samples showed no damage. However, 40% of the LiSi samples fractured during debonding, and 20% exhibited cracks. Only 40% of the LiSi samples were sound after debonding.
Conclusion
Er;Cr:YSGG laser can be used efficiently to remove ceramic occlusal veneers. However, its effect on LiSi restorations needs further research.
A Personalized Cancer Drug Recommendation System with Machine Learning
Authors: Liu Jianyu , He Yu , Li Junfeng 
Published: April 2024

Abstract

The patient’s gene sequence provides valuable information for clinical medication. In practice, there are many different types of data on genes but they are not fully utilized. There are different mutation genes in different cases of cancer, in which there are correlations between them. The gene-based drug recommendation system can be used as an auxiliary tool for clinicians. However, the performance of existing models is not up to the standard of clinical application. In this context, we intend to propose a better-performance drug recommendation system.We propose a multi-kernel ranking learning drug recommendation model, which uses multi-kernel learning methods to extract features from multimodal data and to rank drugs by learning the correlation between different data. Our model achieves performance improvements, especially in the case of simulated clinical sparsity; also has the flexibility to incorporate more multimodal data, which can further optimize the model for potential translation to clinical applications. Despite the limited data used to train and test regression models, model performance was found to be improved. MKRL model can use multimodal data to continuously add to the model for training, and our drug recommendation effect is better than other recommendation models.