bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of Unprecedented Intramolecular 1, 3‐Dipolar Cycloaddition Reaction in meso‐Nitrile Oxide‐Containing BODIPYs as a New Pathway for the Preparation of Fused NIR Platforms
Authors: Zatsikha Yuriy V. , Prasannan Dijo , Scharge Briana , Herbert David E. , Gerasimchuk Nikolay N. , Zeller Mattias , Nemykin Victor N. 
Published: April 2024

AbstractMeso‐nitrile oxide group in 1,7‐Diphenyl‐containing BODIPYs can be involved in highly unusual [3+2] intramolecular cycloaddition reaction with the formation of the dihydrobenzo[d]isoxazole‐containing BODIPYs. Oxidation of these compounds results in the formation of unprecedented either benzisoxazole‐ or benzo[b]azepine‐fused fully conjugated NIR absorbing BODIPYs. The photophysical properties and electronic structures of the target compounds were studied by an array of experimental and theoretical methods.
Recent Development of Transition Metal Complexes as Chemotherapeutic Hypoxia Activated Prodrug (HAP)
Authors: Jagathesan K. , Roy Sovan 
Published: April 2024

AbstractHypoxia is a state characterized by low concentration of Oxygen. Hypoxic state is often found in the central region of solid tumors. Hypoxia is associated with abnormal neovascularization resulted in poor blood flow in tissues and increased proliferation of tumor cells, imbalance between O2 supply and O2 consumption in tumor cells, high concentration of proton and strong reducibility. And, these abnormalities enhance the survival potency of the hypoxic tumours and increase the resistance towards chemotherapy and radiotherapy. One of the approach for treating hypoxic region of tumour is to use reducing environment of hypoxic tumours for reducing a molecule (hypoxia activated prodrug, HAP) and as a result the active drug will be released in hypoxic region in a controlled manner from the prodrug and kill the hypoxic tumour. Co(III) and Pt(IV) complexes with monodentate active drug molecule in the axial position can be reduced to Co(II) and Pt(II) moieties and as a result, the axial ligands (active drug) could come out from the metal center and could show its anticancer activity. In this review we have highlighted the research articles where transition metal‐based complexes are used as chemotherapeutic hypoxia activated prodrug molecules which are reported in last 5 years.
Enhanced Performance of Fe/WO3 Terahertz Dielectric Lenses
Authors: Khanfar Hazem Kholoqi , Qasrawi Atef Fayez 
Published: April 2024

AbstractHerein transparent iron nanosheets deposited by the ionic coating technique onto glass and WO3 dielectric lenses are studied and characterized. The thickness of Fe nanosheets is varied in the range of 70–350 nm. It is observed that the transmittance and reflectance of the Fe nanosheets are highly affected by the layer roughness. Coating of iron nanosheets onto WO3 dielectric lenses increases the light absorption of WO3 by more than 240 times and red‐shifts the energy bandgap. Remarkable enhancements in the dielectric constant and in the optical conductivity are achieved via Fe coatings. In addition, iron coated dielectric lenses show higher terahertz cutoff limits varying in the range of 1.0–30 THz. Iron nanosheets remarkably increase the free charge carrier density and plasmon frequency in the infrared range of light. Moreover, the temperature dependent electrical conductivity shows high temperature stability and an increased electrical conductivity by more than 7 orders of magnitude by coating WO3 with 70 nm thick Fe nanosheets. The stability of the electrical conductivity at low temperatures and the wide range of terahertz cutoff limits in addition to the well‐enhanced light absorbability makes the iron coated tungsten oxide dielectric lenses promising for multifunction optoelectronic applications.
Study of the Corrosion Behavior of Cathode Current Collector in LiFSI Electrolyte
Authors: Yuan Zijie , Wang Yongjing , Chen Yaqi , Zhu Xiaodong , Xiong Shizhao , Song Zhongxiao 
Published: April 2024

AbstractCycling aging is the one of the main reasons affecting the lifetime of lithium‐ion batteries and the contribution of aluminum current collector corrosion to the ageing is not fully recognized. In general, aluminum is corrosion resistant to electrolyte since a non‐permeable surface film of alumina is naturally formed. However, corrosion of aluminum current collector can still occur under certain conditions such as lithium bis(fluorosulfonyl)imide (LiFSI)‐based electrolyte or high voltage. Herein, we investigates the corrosion of aluminum current collector in the electrolyte of 1.2 M LiFSI in ethylene carbonate (EC) and ethyl methyl carbonate (EMC) mixed solvents. The electrochemical results shows that the corrosion current of aluminum is enhanced by cycling time and potential, which is correlated with the surface species and morphology. The formation of AlF3, which is induced by deep penetration of F− anions through surface passivation film, leads to internal volume change and the surface crack in the end. Our work will be inspiring for future development of high‐energy‐density and high‐power‐density lithium‐ion batteries in which the LiFSI salt will be intensively used.
Boring systematics: A genome skimmed phylogeny of ctenostome bryozoans and their endolithic family Penetrantiidae with the description of one new species
Authors: Decker Sebastian H. , Saadi Ahmed J. , Baranyi Christian , Hirose Masato , Lemer Sarah , Sombke Andy , Aguilera Felipe , Vieira Leandro M. , Smith Abigail M. , Waeschenbach Andrea , Schwaha Thomas 
Published: April 2024

AbstractCtenostomes are a group of gymnolaemate bryozoans with an uncalcified chitinous body wall having few external, skeletal characters. Hence, species identification is challenging and their systematics remain poorly understood, even more so when they exhibit an endolithic (boring) lifestyle. Currently, there are four Recent families of endolithic bryozoans that live inside mineralized substrates like mollusk shells. In particular, Penetrantiidae Silén, 1946 has received considerable attention and its systematic affinity to either cheilostomes or ctenostomes has been debated. Species delimitation of penetrantiids remains difficult, owing to a high degree of colonial and zooidal plasticity. Consequently, an additional molecular approach is essential to unravel the systematics of penetrantiids, their phylogenetic placement and their species diversity. We therefore sequenced the mitochondrial (mt) genomes and two nuclear markers of 27 ctenostome species including nine penetrantiids. Our phylogeny supports the Penetrantiidae as a monophyletic group placed as sister taxon to the remaining ctenostomes alongside paludicellids, arachnidioids and terebriporids. The boring family Terebriporidae d'Orbigny, 1847 were previously considered to be among vesicularioids, but our results suggest an arachnidioid affinity instead. Ctenostome paraphyly is supported by our data, as the cheilostomes nest within them. A Multiporata clade is also well supported, including the former victorelloid genus Sundanella. Altogether, this study provides new insights into ctenostome systematics, assists with species delimitation and contributes to our understanding of the bryozoan tree of life.
MicroRNAs targeting TGF‐β signaling exacerbate central nervous system autoimmunity by disrupting regulatory T cell development and function
Authors: Rau Christina N. , Severin Mary E. , Lee Priscilla W. , Deffenbaugh Joshua L. , Liu Yue , Murphy Shawn P. , Petersen‐Cherubini Cora L. , Lovett‐Racke Amy E. 
Published: April 2024

AbstractTransforming growth factor beta (TGF‐β) signaling is essential for a balanced immune response by mediating the development and function of regulatory T cells (Tregs) and suppressing autoreactive T cells. Disruption of this balance can result in autoimmune diseases, including multiple sclerosis (MS). MicroRNAs (miRNAs) targeting TGF‐β signaling have been shown to be upregulated in naïve CD4 T cells in MS patients, resulting in a limited in vitro generation of human Tregs. Utilizing the murine model experimental autoimmune encephalomyelitis, we show that perinatal administration of miRNAs, which target the TGF‐β signaling pathway, enhanced susceptibility to central nervous system (CNS) autoimmunity. Neonatal mice administered with these miRNAs further exhibited reduced Treg frequencies with a loss in T cell receptor repertoire diversity following the induction of experimental autoimmune encephalomyelitis in adulthood. Exacerbated CNS autoimmunity as a result of miRNA overexpression in CD4 T cells was accompanied by enhanced Th1 and Th17 cell frequencies. These findings demonstrate that increased levels of TGF‐β‐associated miRNAs impede the development of a diverse Treg population, leading to enhanced effector cell activity, and contributing to an increased susceptibility to CNS autoimmunity. Thus, TGF‐β‐targeting miRNAs could be a risk factor for MS, and recovering optimal TGF‐β signaling may restore immune homeostasis in MS patients.
Catalyst‐free Chloroamination Cyclization Cascade with Sodium Hypochlorite: from N‐(Pentenyl)sulfonylamides to 2‐(1‐Chloromethyl)pyrrolidines
Authors: Scarfiello Jacopo , Rusconi Marco , Lanfranco Alberto , Azzi Emanuele , Caracciolo Stefano , Ghigo Giovanni , Renzi Polyssena , Deagostino Annamaria 
Published: April 2024

AbstractA mild and catalyst‐free protocol to obtain several 2‐chloromethylpyrrolidines by the use of a commercial solution of sodium hypochlorite is here reported, without the need for a light source. The choice of the solvent revealed to be crucial in the success of the reaction. Mechanistic studies, both experimental and computational, confirmed a radical mechanism, where the deprotonation step, followed by the oxidation of a N‐centered anion to the corresponding radical, allowed 2‐chloromethylpyrrolidines, by a very fast cyclization, to be obtained. Sodium hypochlorite plays the role of both the oxidant and the chlorine source.
Structure‐Activity Relationships of Glucose‐based PdII‐Bis(NHC) Complexes in a Model Suzuki‐Miyaura Reaction
Authors: Ziems Hannes , Komabayashi Mirai , Lehmann Paul , Villinger Alexander , Jopp Stefan 
Published: April 2024

AbstractThe authors of this work have optimized a novel synthetic route towards glucose‐based PdII‐bis(NHC) complexes in only 4 steps with total yields up to 73 %. The synthesis route encompasses an Appel reaction towards 6‐iodo‐glucopyranosides, followed by acyl‐protection, then quaternization with imidazoles and finally the conversion of these acyl‐protected glucosyl imidazolium salts to their respective palladium(II)bis(NHC) complexes, via an intermediary silver(I) complex. Overall, 11 acyl‐protected glucosyl imidazolium iodides as NHC‐precursors and 15 complexes have been synthesized. The structure‐activity relationships of different functionalizations in these complexes and their reactivity in a model Suzuki‐Miyaura between bromobenzene and 4‐tolueneboronic acid reaction has been investigated, and a highly reactive complex leading to >99 % yield at 0.005 mol% catalytic loading has been found.
Improving predictions of critical shear stress in gravel bed rivers: Identifying the onset of sediment transport and quantifying sediment structure
Authors: Hodge Rebecca A. , Voepel Hal E. , Yager Elowyn M. , Leyland Julian , Johnson Joel P. L. , Sear David A. , Ahmed Sharif 
Published: April 2024

AbstractUnderstanding when gravel moves in river beds is essential for a range of different applications but is still surprisingly hard to predict. Here we consider how our ability to predict critical shear stress (τc) is being improved by recent advances in two areas: (1) identifying the onset of bedload transport; and (2) quantifying grain‐scale gravel bed structure. This paper addresses these areas through both an in‐depth review and a comparison of new datasets of gravel structure collected using three different methods. We focus on advances in these two areas because of the need to understand how the conditions for sediment entrainment vary spatially and temporally, and because spatial and temporal changes in grain‐scale structure are likely to be a major driver of changes in τc. We use data collected from a small gravel‐bed stream using direct field‐based measurements, terrestrial laser scanning (TLS) and computed tomography (CT) scanning, which is the first time that these methods have been directly compared. Using each method, we measure structure‐relevant metrics including grain size distribution, grain protrusion and fine matrix content. We find that all three methods produce consistent measures of grain size, but that there is less agreement between measurements of grain protrusion and fine matrix content.
Acute Toxicity of the Lampricide 4-Nitro-3-(trifluoromethyl)phenol to the Mussel (Obovaria subrotunda), Its Host (Percina maculata), and a Surrogate Mussel Species (Obovaria olivaria)
Authors: Newton Teresa J. , Schloesser Nicholas A. , Kaye Cheryl A. , Andresen Chad K. , Boogaard Michael A. , Carter Christina M. , Ellingson Ryan J. , Kirkeeng Courtney A. , Schueller Justin R. 
Published: April 2024

Abstract
The risk of lampricide applications (such as 4-nitro-3-[trifluoromethyl]phenol [TFM]) to nontarget fauna continues to be a concern within the Great Lakes Fishery Commission Sea Lamprey Control Program, especially among imperiled aquatic species—such as native freshwater mussels. The Grand River (Ohio, USA) is routinely treated for larval sea lampreys (Petromyzon marinus), and this river contains populations of the federally threatened mussel Obovaria subrotunda. Given this spatial overlap, information on the sensitivity of O. subrotunda to TFM is needed. Our objectives were to assess the toxicity of TFM to (1) adult Obovaria olivaria (a surrogate for O. subrotunda), (2) glochidial larvae of O. olivaria and O. subrotunda, (3) juveniles of O. olivaria and O. subrotunda, and (4) adult Percina maculata (host for O. subrotunda glochidia). In acute toxicity tests, TFM was not toxic to glochidia and adult mussels at exposure concentrations that exceed typical treatment rates. Although significant dose–response relationships were observed in hosts and juveniles, survival was ≥95% (Percina maculata), ≥93% (O. olivaria), and ≥74% (O. subrotunda) at typical treatment rates. However, the steep slope of these dose–response relationships indicates that an approximately 20% difference in the treatment level can result in nearly an order of magnitude difference in survival. Collectively, these data indicate that routine sea lamprey control operations are unlikely to acutely affect these species or their host. However, given that many mussel species are long-lived (30–100 years), the risks posed by lampricide treatments in the Great Lakes would be further informed by research on the potential long-term effects of lampricides on imperiled species. Environ Toxicol Chem 2024;43:1423–1430. Published 2024. This article is a U.S. Government work and is in the public domain in the USA.
Performance of spray‐dried Ziziphus jujuba extract using insoluble fraction of Persian gum–sodium alginate and whey protein: Microstructural and physicochemical attributes of micro‐ and nano‐capsules
Authors: Khoshdouni Farahani Zahra , Ebrahimzadeh Mousavi Mohamad , Seyedain Ardebili Mahdi , Mohammadi Nafchi Abdorreza , Paidssari Saeed 
Published: April 2024

AbstractThe study focused on the impact of the insoluble fraction of Persian gum–sodium alginate and a blend of the insoluble fraction of Persian gum–sodium alginate (IFPG‐Al) with whey protein isolate (WPI) on sprayed Ziziphus jujuba extract (JE) powder. The addition of whey protein led to powders with higher moisture (10%), higher solubility (99.19%), and lower powder yield (27.82%). The powders fabricated with WPI depicted the best protection of polyphenolic compounds (3933.4 mg/L) and the highest encapsulation efficiency activity (74.84%). Additionally, they had a higher Tg (62.63°C), which indicates more stability of the powders during shelf life. The sphericity of the majority of the particles was noticeable in powders, but multi‐sided concavities were visible in the protein‐containing particles. Based on the particle size's results, IFPG‐Al/WPI capsules fabricated relatively smaller particles (2.54 μm). It can be acknowledged that the presence of protein in particles can bring fruitful results by preserving valuable bioactive compounds.
The impact of the COVID‐19 pandemic on reproductive intentions and contraceptive use among females in Jeddah, Saudi Arabia
Authors: Abualsaud Renad M. , Aldhubabian Nouf Ahmad , Alharthi Abdulaziz Matar , Alzahrani Maha Ahmed , Balto Ghadah Emadaldeen , Malak Mohammed M. 
Published: April 2024

AbstractObjectivePandemics have affected many people's social and emotional lives. Conception planning, contraceptive usage, and pregnancy intentions are activities with minimal research. This study is the first to evaluate how the COVID‐19 pandemic influenced reproductive plans and contraceptive use among women during the pandemic in Jeddah, Saudi Arabia, in 2022.MethodsA cross‐sectional survey was conducted by sending an online questionnaire to married women from Jeddah, Saudi Arabia. The questionnaire included demographics, personal obstetrics information, changes in pregnancy intentions owing to the COVID‐19 pandemic, and questions about contraceptive usage. Qualitative data were presented as frequencies, and a χ2 test was performed to determine the relationships among the variables.ResultsA total of 639 women enrolled in the study; most participants were 25–34 years old, and most indicated they changed their reproductive intentions during the pandemic (49%). Family planning accounted for 25.8% of participants who changed their reproductive intentions. Only 17.5% changed their choices because of fear of the COVID‐19 impact. The percentage of women using contraception was significantly reduced during the lockdown, to 36.8%. Oral contraceptive pills were the most frequently used method during the curfew period (17.5%).ConclusionThe COVID‐19 lockdown affected the reproductive intentions of most women in Jeddah, and it significantly reduced contraceptive use.
Exploring barriers, drivers, and routines of dynamic capabilities in Indonesian digital banking transformation: A qualitative study based on the TOE framework
Authors: Abdurrahman Abdurrahman , Gustomo Aurik , Prasetio Eko Agus 
Published: April 2024

AbstractThis study is rooted in the necessity to gain a thorough comprehension of organizational capabilities essential for embedding dynamic capabilities (DC) according to the technology‐organization‐environment (TOE) within the landscape of digital transformation (DT). We have observed a surge in recent research focused on DC in the context of DT, however, there is still ample room for exploration to address the complex barriers, drivers, and routines associated with each DC capability, all crucial for achieving successful DT. Our approach employs a qualitative study involving interviews with 18 banking professionals based in Indonesia. Our study's findings have identified six DCs based on the TOE framework that can be effectively employed to facilitate successful DT including the technology capability for the technology dimension, strategy, organizational, and innovation capability for the environment perspective, and environment factor consisting of ecosystem and governance‐risk management‐ compliance (GRC). Delving into these six capabilities, we have explored the barriers, drivers, and routines linked with each. Additionally, our study has facilitated the alignment of DT benefits with expected performance outcomes, thus empowering companies to prioritize DT initiatives in alignment with their performance objectives. From a theoretical standpoint, this research contributes by offering an extensive comprehension of the factors and routines intrinsic to DC based on the TOE framework within the context of DT. From a managerial perspective, it provides guidance to companies as they navigate the realm of DT through a comprehensive lens focused on the DC.
Language and reading in attention‐deficit/hyperactivity disorder and comorbid attention‐deficit/hyperactivity disorder + developmental language disorder
Authors: Parks Kaitlyn M. A. , Cardy Janis Oram , Joanisse Marc F. 
Published: April 2024

AbstractBackgroundThe current study sought to examine whether psycholinguistic assessments could discriminate children and adolescents with developmental language disorder (DLD) from those with attention‐deficit/hyperactivity disorder (ADHD; combined or inattentive subtype) and comorbid DLD + ADHD.MethodsThe Clinical Evaluation of Language Fundamentals—Screening Test (CELFST; Wiig et al., 2013), the Comprehensive Test of Phonological Processing (nonword repetition subtest; Wagner et al., 2013), and the Test of Word Reading Efficiency (sight word and phonemic decoding subtests; Torgesen et al., 2012) were examined in 441 children and adolescents between 6 and 16 years of age.ResultsThe presence of a language disorder (with or without ADHD) predicted poor performance across tasks. Children and adolescents with ADHD (combined vs. inattentive) only significantly differed in sight word reading, in favor of those with combined type. Measures of reading efficiency could distinguish between the two types of ADHD, but not between other groups. Interestingly, scores on the standard language screener were no worse for children with ADHD + DLD than children with DLD only.ConclusionsThe combination of comorbid ADHD + DLD did not appear to be associated with lower language abilities, sight word reading, or phonemic decoding relative to DLD alone. Reading efficiency was effective in discriminating between ADHD subtypes. These findings offer valuable insights into differential diagnosis and the identification of comorbidity.
Evaluating a method of creating artificial caries in typodont teeth for teaching Class III cavity preparations
Authors: Park Kidon , Asnashari Kasra , Younan Reema , Becker Ryan , Roggenkamp Clyde , Oyoyo Udochukwu , Kwon So Ran 
Published: April 2024

AbstractObjectivesThe purpose of the study was to report a step‐by‐step process of creating artificial caries typodont teeth and to determine the perception and efficacy of their use in preclinical operative training.MethodsArtificial caries material comprised of commercially available hide glue and chocolate powder for more realistic coloring was embedded into the distolingual of #9 ModuPRO plastic typodont teeth. First‐year dental students having no clinical experience in excavating Class III cavity preparations were divided into two groups. Group BA prepared conventional typodont teeth (CTT) first, then artificial caries typodont teeth. Group AB prepared the ACT first, then CTT. The preps were scored employing a rubric used in the operative dentistry course class. A feedback questionnaire was conducted to rate students’ satisfaction regarding the use of ACT and CTT. The Mann–Whitney U‐test was used to compare the scores between groups ACT–CTT and CTT–ACT and the Chi‐Square test was used to evaluate the positive and negative questionnaire responses.ResultsThe two groups showed no significant difference in grades and no significant changes in their scores regardless of which order they prepped the teeth (P > 0.05). The questionnaire heavily favored the use of artificial caries typodont teeth (P < 0.05).ConclusionsThe artificial caries typodont teeth protocol described in this study was feasible when implemented at the preclinical laboratory instruction level with positive questionnaire feedback from dental students.