bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identifying the Correlates of Individual, Peer and Systemic Advocacy Among Parents of Children with Disabilities Who are Interested in Civic Engagement
Authors: Burke Meghan M. , Li Chak , Cheung Waifong Catherine , Johnston Amanda , Best Megan , Fulton Kelly , Hardy Abby , Rossetti Zach 
Published: April 2024

AbstractParent advocacy is often critical for families of individuals with disabilities. Prior research has suggested that parent advocacy occurs across three levels: individual, peer, and systemic. Yet, little empirical research has identified the correlates of advocacy for each level. For this study, we examined the survey responses of 246 parents of individuals with disabilities who were interested in participating in a legislative advocacy program. Analyses included hierarchical regressions to identify the correlates of individual, peer, and systemic advocacy. Parents of children with autism were significantly more likely to engage in individual advocacy. Parents who identified as Black (versus other racial groups) advocated significantly more on a systemic level. Further, malleable factors such as empowerment and motivation correlated positively with advocacy. Implications for research and practice are discussed.
Next-generation probiotics: the upcoming biotherapeutics
Authors: Al-Fakhrany Omnia Momtaz , Elekhnawy Engy 
Published: April 2024

Abstract
Recent and continuing advances in gut microbiome research have pointed out the role of the gut microbiota as an unexplored source of potentially beneficial probiotic microbes. Along the lines of these advances, both public awareness and acceptance of probiotics are increasing. That’s why; academic and industrial research is dedicated to identifying and investigating new microbial strains for the development of next-generation probiotics (NGPs). At this time, there is a growing interest in NGPs as biotherapeutics that alter the gut microbiome and affect various diseases development. In this work, we have focused on some emergent and promising NGPs, specifically Eubacterium hallii, Faecalibacterium prausnitzii, Roseburia spp., Akkermansia muciniphila, and Bacteroides fragilis, as their presence in the gut can have an impact on the development of various diseases. Emerging studies point out the beneficial roles of these NGPs and open up novel promising therapeutic options. Interestingly, these NGPs were found to enhance gastrointestinal immunity, enhance immunotherapy efficacy in cancer patients, retain the intestinal barrier integrity, generate valuable metabolites, especially short-chain fatty acids, and decrease complications of chemotherapy and radiotherapy. Although many of these NGPs are considered promising for the prevention and treatment of several chronic diseases, research on humans is still lacking. Therefore, approval of these microbes from regulatory agencies is rare. Besides, some issues limit their wide use in the market, such as suitable methods for the culture and storage of these oxygen-sensitive microbes. The present review goes over the main points related to NGPs and gives a viewpoint on the key issues that still hinder their wide application. Furthermore, we have focused on the advancement in NGPs and human healthiness investigations by clarifying the limitations of traditional probiotic microorganisms, discussing the characteristics of emerging NGPs and defining their role in the management of certain ailments. Future research should emphasize the isolation, mechanisms of action of these probiotics, safety, and clinical efficacy in humans.
How to compute multivariate Bessel expansions
Authors: Durán Antonio J. , Pérez Mario , Varona Juan L. 
Published: April 2024

AbstractWe develop a constructive method for computing explicitly multivariate Bessel expansions of the type $$\begin{aligned} \sum _{m\ge 1} \alpha _m \prod _{i=1}^k \frac{J_{\mu _i}(\zeta _m x_i)}{(\zeta _m x_i)^{\mu _i}}, \end{aligned}$$

∑

m
≥
1

α
m

∏

i
=
1

k

J

μ
i

(

ζ
m

x
i

)

(

ζ
m

x
i

)

μ
i

,

assuming that for a particular value $$\eta $$
η
a closed expression for the single-variable Bessel expansion $$\begin{aligned} \sum _{m\ge 1}\alpha _m \frac{J_{\eta }(\zeta _m x)}{(\zeta _m x)^\eta } \end{aligned}$$

∑

m
≥
1

α
m

J
η

(

ζ
m

x
)

(

ζ
m

x
)

η

as a power series of $$x^{2j}$$

x

2
j

, $$j\in \mathbb {N}$$

j
∈
N

, is known. Using the method we compute in a closed form a bunch of examples of multivariate Bessel expansions.
Performance improvement of the triangular matrix product in commodity clusters
Authors: Santamaria-Valenzuela Inmaculada , Carratalá-Sáez Rocío , Torres Yuri , Llanos Diego R. , Gonzalez-Escribano Arturo 
Published: April 2024

AbstractThere are many works devoted to improving the matrix product computation, as it is used in a wide variety of scientific applications arising from many different fields. In this work, we propose alternative data distribution policies and communication patterns to reduce the elapsed time when computing triangular matrix products in distributed memory environments. In particular, we focus on commodity clusters, where the number of nodes is limited, proposing alternatives to traditional approaches in order to improve this operation’s performance. Our proposal overcomes the performance results associated with the state-of-the-art libraries, such as ScaLAPACK and SLATE, offering execution times that are up to 30% faster.
Regression analysis for the determination of microplastics in sediments using differential scanning calorimetry
Authors: Schirrmeister Sven , Kurzweg Lucas , Gjashta Xhoen , Socher Martin , Fery Andreas , Harre Kathrin 
Published: April 2024

AbstractThis research addresses the growing need for fast and cost-efficient methods for microplastic (MP) analysis. We present a thermo-analytical method that enables the identification and quantification of different polymer types in sediment and sand composite samples based on their phase transition behavior. Differential scanning calorimetry (DSC) was performed, and the results were evaluated by using different regression models. The melting and crystallization enthalpies or the change in heat capacity at the glass transition point were measured as regression analysis data. Ten milligrams of sea sand was spiked with 0.05 to 1.5 mg of microplastic particles (size: 100 to 200 µm) of the semi-crystalline polymers LD-PE, HD-PE, PP, PA6, and PET, and the amorphous polymers PS and PVC. The results showed that a two-factorial regression enabled the unambiguous identification and robust quantification of different polymer types. The limits of quantification were 0.13 to 0.33 mg and 0.40 to 1.84 mg per measurement for semi-crystalline and amorphous polymers, respectively. Moreover, DSC is robust with regard to natural organic matrices and allows the fast and non-destructive analysis of microplastic within the analytical limits. Hence, DSC could expand the range of analytical methods for microplastics and compete with perturbation-prone chemical analyses such as thermal extraction–desorption gas chromatography–mass spectrometry or spectroscopic methods. Further work should focus on potential changes in phase transition behavior in more complex matrices and the application of DSC for MP analysis in environmental samples.
Management of dredged marine sediments in Southern France: main keys to large-scale beneficial re-use
Authors: Dorleon Garry , Rigaud Sylvain , Techer Isabelle 
Published: April 2024

AbstractFifty million cubic meters of marine sediments are dredged each year in France in order to maintain harbor activities and sustain the economy of littoral territories. Because of anthropogenic activities in and around harbors, sediments can contain significant amounts of chemical and organic pollutants whose behavior during dredging must be addressed in order to avoid releasing risks for humans and the environment. French regulations come to govern the management of dredged sediments, considering them “safe” and possible to be dumped at sea or “contaminated” and needed to be treated on land as waste. In recent years, new constraints have been pushed toward the management of land. This management is, however, challenging as few channels are proposed to reuse marine sediments, and elimination appears to be economically and environmentally unsustainable. This study provides an overview of the technical and regulatory aspects related to dredged marine sediment management in France and aims to identify and discuss the limits of their valorization. Dredged sediments are mainly composed of particles with heterogeneous grain size, some being known for many applications such as building materials and growing media. However, several reasons have been put forward to explain why these particles are not reused when extracted from dredged sediments. Several technical, socio-economic, and regulatory obstacles explain the low demand for dredged sediments. This demand can be stimulated by government incentives and a good regulatory framework. National regulations could help streamline their reuse by removing their “waste” status and creating a regulated market for dredged sediment.
The impact of positive and negative psychological affect and overconfidence from major family events on new venture survival
Authors: Seet Pi-Shen , Tan Wee-Liang 
Published: April 2024

AbstractThis paper investigates how family events interacting with entrepreneurs’ psychological affect and overconfidence impact new venture viability. We use panel data from the Australian Household, Income and Labor Dynamics survey, focusing on family event-induced psychological affect entrepreneurs experience as a predictor of new venture survival. Our accelerated failure time model shows that although negative family events interact with entrepreneur overconfidence to spur cautious behaviour, positive events interacting with overconfidence have the biggest impact (negative) on new ventures. The study enhances our understanding of the embeddedness of family in the entrepreneurial process and challenges past research by revealing how positive family events can have a greater negative impact on new venture survival than negative ones.
Heart failure, recurrent vascular events and death in patients with ischemic stroke—results of the MonDAFIS study
Authors: Tütüncü Serdar , Olma Manuel C. , Kunze Claudia , Dietzel Joanna , Schurig Johannes , Rosenkranz Michael , Stingele Robert , Maschke Matthias , Heuschmann Peter U. , Kirchhof Paulus , Laufs Ulrich , Nabavi Darius G. , Röther Joachim , Thomalla Götz , Veltkamp Roland , Endres Matthias , Haeusler Karl Georg ,   for the MonDAFIS Investigators
Published: April 2024

AbstractHeart failure (HF) is associated with poor outcome after stroke, but data from large prospective trials are sparse.We assessed the impact of HF on clinical endpoints in patients hospitalized with acute ischemic stroke or transient ischemic attack (TIA) enrolled in the prospective, multicenter Systematic Monitoring for Detection of Atrial Fibrillation in Patients with Acute Ischemic Stroke (MonDAFIS) trial. HF was defined as left ventricular ejection fraction (LVEF) < 55% or a history of HF on admission. The composite of recurrent stroke, major bleeding, myocardial infarction, and all-cause death, and its components during the subsequent 24 months were assessed. We used estimated hazard ratios in confounder-adjusted models. Overall, 410/2562 (16.0%) stroke patients fulfilled the HF criteria (i.e. 381 [14.9%] with LVEF < 55% and 29 [1.9%] based on medical history). Patients with HF had more often diabetes, coronary and peripheral arterial disease and presented with more severe strokes on admission. HF at baseline correlated with myocardial infarction (HR 2.21; 95% CI 1.02–4.79), and all-cause death (HR 1.67; 95% CI 1.12–2.50), but not with major bleed (HR 1.93; 95% CI 0.73–5.06) or recurrent stroke/TIA (HR 1.08; 95% CI 0.75–1.57). The data were adjusted for age, stroke severity, cardiovascular risk factors, and randomization. Patients with ischemic stroke or TIA and comorbid HF have a higher risk of myocardial infarction and death compared with non-HF patients whereas the risk of recurrent stroke or major hemorrhage was similar. Trial registration number Clinicaltrials.gov NCT02204267.
Holistic Processing of Sawdust to Enable Sustainable Hybrid Li-Ion Capacitors
Authors: Guo Xiaoyang , van de Kleut Dick , Zhang Jia , Chen Chaofan , Wang Xuehang , Zheng Tianye , Boles Steven 
Published: April 2024

AbstractActivated carbon has long been recognized as a promising electrode material for energy storage devices. The extraordinarily high specific area makes it challenging to replace in supercapacitors since electrical double-layer capacitors need such surfaces but also porous networks to enable electrolyte penetration. As a raw material for synthesizing activated carbon, sawdust offers key benefits, such as its renewability, abundance, favorable physical attributes for energy storage, and a more environmentally friendly synthesis process compared to mined alternative sources. In this work, electrochemical characterization is carried out which highlights the critical role of pelletization in enhancing the capacitive performance of sawdust-derived activated carbon, in addition to the implicit handling and logistical benefits. Subsequently, a Li-ion capacitor is assembled with an organic solvent-based electrolyte, sawdust-derived activated carbon serving as the positive electrode, and an Al-based foil negative electrode, potentially combining high energy and power density materials into a hybrid device. Despite commendable electrochemical performance and the use of a sustainable waste-derived positive electrode with a commoditized negative electrode, challenges remain regarding the ability to mitigate the role of surface functional groups that are stabilized by bio-carbon thermal treatments. Nevertheless, this distinctive architecture holds promise as an alternative high-power energy storage technology for a future filled with renewable energy, electric vehicles, and portable electronic devices.
Pulsed Electric Field Treatment of Oat and Barley Flour: Influence on Enzymes, Non-starch Polysaccharides, Dough Rheological Properties, and Application in Flat Bread
Authors: Grgić Tomislava , Bleha Roman , Smrčkova Petra , Stulić Višnja , Pavičić Tomislava Vukušić , Synytsya Andriy , Iveković Damir , Novotni Dubravka 
Published: April 2024

AbstractThis study examined the effects of pulsed electric field (PEF) treatment on enzymes, non-starch polysaccharides, and bread-making potential of oat and barley flour. Enzyme activity, microstructure, β-glucan extractability, molecular weight (Mw) and structure of non-starch polysaccharides, dough rheology, and flat bread properties were determined. An exponential decay model explained better the residual activity of oat β-glucanase across electric field intensity than barley β-glucanase. PEF treatment of flour at 12 kV/cm for 162 ms significantly reduced β-glucanase activity (40.2–76.5%) while increasing the concentration of total β-glucans (33.5%) and water-extractable arabinoxylans (36–41%). Mw of linear β-d-glucans decreased (9%) while Mw of branched arabinoxylans increased (6–33%). Scanning electron microscopy showed changes in microstructure of barley proteins. Blending wheat flour (70%) with oat or barley flour (30% weight) after PEF treatment enhanced gluten aggregation energy (29–19%) and breakdown viscosity (18–43%) of dough, as well as increased β-glucan content (21–32%) but reduced specific volume (11–24%). The findings of this study provide a comprehensive insight into the PEF’s potential for retarding enzymatic reactions and preserving integrity of cereal non-starch polysaccharides.
Drug Treatment Attenuates Retinal Ganglion Cell Death by Inhibiting Collapsin Response Mediator Protein 2 Phosphorylation in Mouse Models of Normal Tension Glaucoma
Authors: Wang Yuebing , Brahma Musukha Mala , Takahashi Kazuya , Hernandez Alessandra Nolia Blanco , Ichikawa Koki , Minami Syuntaro , Goshima Yoshio , Harada Takayuki , Ohshima Toshio 
Published: April 2024

AbstractNormal tension glaucoma (NTG) is a progressive neurodegenerative disease in glaucoma families. Typical glaucoma develops because of increased intraocular pressure (IOP), whereas NTG develops despite normal IOP. As a subtype of open-angle glaucoma, NTG is characterized by retinal ganglion cell (RGC) degeneration, gradual loss of axons, and injury to the optic nerve. The relationship between glutamate excitotoxicity and oxidative stress has elicited great interest in NTG studies. We recently reported that suppressing collapsin response mediator protein 2 (CRMP2) phosphorylation in S522A CRMP2 mutant (CRMP2 KIKI) mice inhibited RGC death in NTG mouse models. This study evaluated the impact of the natural compounds huperzine A (HupA) and naringenin (NAR), which have therapeutic effects against glutamate excitotoxicity and oxidative stress, on inhibiting CMRP2 phosphorylation in mice intravitreally injected with N-methyl-d-aspartate (NMDA) and GLAST mutant mice. Results of the study demonstrated that HupA and NAR significantly reduced RGC degeneration and thinning of the inner retinal layer, and inhibited the elevated CRMP2 phosphorylation. These treatments protected against glutamate excitotoxicity and suppressed oxidative stress, which could provide insight into developing new effective therapeutic strategies for NTG.
Improving the hydrostability of zeolitic imidazolate framework coatings using a facile silk fibroin protein modification method
Authors: Wei Xiuming , Chen Ting , Chen Siyu , Jia Qian , Mazlan Nurul Ain , Lewis Allana , Radacsi Norbert , Huang Yi 
Published: April 2024

AbstractZeolitic imidazolate frameworks (ZIFs) are an important subclass of metal-organic frameworks (MOFs) with zeolite-type topology, which can be fabricated under ambient synthesis conditions. However, the applications of ZIFs are commonly limited due to the weak hydrostability of their metal–ligand coordination bonds, particularly under humid and aqueous conditions. In this work, as an example, the hydrolysis behaviours of ZIF-L with a special focus on ZIF-L coatings were tested at aqueous conditions with a wide range of pHs to systematically study and fundamentally understand their structural stability and degradation mechanism. Pristine ZIF-L powder and ZIF-L coatings were severely damaged after only 24 h in aqueous media. Interestingly, the ZIF-L coatings showed two distinct hydrolyzation pathways regardless of pH conditions, exhibiting either a ring-shaped etching or unfolding behaviours. While the ZIF-L powders were hydrolyzed almost identically across all pH conditions. With this new understanding, a facile silk fibroin (SF) protein modification method was developed to enhance the hydrostability of ZIF-L coatings in aqueous media. The effect of protein concentration on surface coating was systemically studied. ZIF-L coating retained its surface morphology after soaking in water and demonstrated switchable super wetting properties and superior separation performance for oil/water mixture. As a result, the quick SF protein modification significantly enhanced the stability of ZIF-L coatings under various pHs, while retaining their switchable wetting property and excellent separation performance.
Circular RNA COL1A1 promotes Warburg effect and tumor growth in nasopharyngeal carcinoma
Authors: Zhou ZeJun , Xu Fang , Zhang Tao 
Published: April 2024

Abstract
Objective
Circular RNAs (circRNAs), pivotal in the pathogenesis and progression of nasopharyngeal carcinoma (NPC), remain a significant point of investigation for potential therapeutic interventions. Our research was driven by the objective to decipher the roles and underlying mechanisms of hsa_circ_0044569 (circCOL1A1) in governing the malignant phenotypes and the Warburg effect in NPC.

Methods
We systematically collected samples from NPC tissues and normal nasopharyngeal epithelial counterparts. The expression levels of circCOL1A1, microRNA-370-5p (miR-370-5p), and prothymosin alpha (PTMA) were quantitatively determined using quantitative polymerase chain reaction (qPCR) and Western blotting. Transfections in NPC cell lines were conducted using small interfering RNAs (siRNAs) or vectors carrying the pcDNA 3.1 construct for overexpression studies. We interrogated the circCOL1A1/miR-370-5p/PTMA axis's role in cellular functions through a series of assays: 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide for cell viability, colony formation for growth, Transwell assays for migration and invasion, and Western blotting for protein expression profiling. To elucidate the molecular interactions, we employed luciferase reporter assays and RNA immunoprecipitation techniques.

Results
Our investigations revealed that circCOL1A1 was a stable circRNA, highly expressed in both NPC tissues and derived cell lines. A correlation analysis with clinical pathological features demonstrated a significant association between circCOL1A1 expression, lymph node metastasis, and the tumor node metastasis staging system of NPC. Functionally, silencing circCOL1A1 led to substantial suppression of cell proliferation, migration, invasion, and metabolic alterations characteristic of the Warburg effect in NPC cells. At the molecular level, circCOL1A1 appeared to modulate PTMA expression by acting as a competitive endogenous RNA or 'sponge' for miR-370-5p, which in turn promoted the malignant characteristics of NPC cells.

Conclusion
To conclude, our findings delineate that circCOL1A1 exerts its oncogenic influence in NPC through the modulation of the miR-370-5p/PTMA signaling axis.
T cell-mediated tumor killing sensitivity gene signature-based prognostic score for acute myeloid leukemia
Authors: Pan Yiyun , Xie FangFang , Zeng Wen , Chen Hailong , Chen Zhengcong , Xu Dechang , Chen Yijian 
Published: April 2024

Abstract
Background and Objective
Acute myeloid leukemia (AML) is an aggressive, heterogenous hematopoetic malignancies with poor long-term prognosis. T-cell mediated tumor killing plays a key role in tumor immunity. Here, we explored the prognostic performance and functional significance of a T-cell mediated tumor killing sensitivity gene (GSTTK)-based prognostic score (TTKPI).

Methods
Publicly available transcriptomic data for AML were obtained from TCGA and NCBI-GEO. GSTTK were identified from the TISIDB database. Signature GSTTK for AML were identified by differential expression analysis, COX proportional hazards and LASSO regression analysis and a comprehensive TTKPI score was constructed. Prognostic performance of the TTKPI was examined using Kaplan–Meier survival analysis, Receiver operating curves, and nomogram analysis. Association of TTKPI with clinical phenotypes, tumor immune cell infiltration patterns, checkpoint expression patterns were analysed. Drug docking was used to identify important candidate drugs based on the TTKPI-component genes.

Results
From 401 differentially expressed GSTTK in AML, 24 genes were identified as signature genes and used to construct the TTKPI score. High-TTKPI risk score predicted worse survival and good prognostic accuracy with AUC values ranging from 75 to 96%. Higher TTKPI scores were associated with older age and cancer stage, which showed improved prognostic performance when combined with TTKPI. High TTKPI was associated with lower naïve CD4 T cell and follicular helper T cell infiltrates and higher M2 macrophages/monocyte infiltration. Distinct patterns of immune checkpoint expression corresponded with TTKPI score groups. Three agents; DB11791 (Capmatinib), DB12886 (GSK-1521498) and DB14773 (Lifirafenib) were identified as candidates for AML.

Conclusion
A T-cell mediated killing sensitivity gene-based prognostic score TTKPI showed good accuracy in predicting survival in AML. TTKPI corresponded to functional and immunological features of the tumor microenvironment including checkpoint expression patterns and should be investigated for precision medicine approaches.