bluuebunny/crossref_metadata_2025_split huggingface dataset:
Population‐based prevalence of CDKN2A and CDK4 mutations in patients with multiple primary melanomas
Authors: Helsing Per , Nymoen Dag Andre , Ariansen Sarah , Steine Solrun J. , Maehle Lovise , Aamdal Steinar , Langmark Frøydis , Loeb Mitchell , Akslen Lars A. , Molven Anders , Andresen Per Arne 
Published: November 2007

AbstractThe presence of multiple primary cutaneous melanomas (MPM) has been advocated as guidance to identifying melanoma families. Frequencies of CDKN2A mutations in materials of sporadic MPM cases from pigmented lesion clinics vary between 8 and 15%. Patients with MPM have therefore been regarded as good candidates for CDKN2A mutational screening. We describe a population‐based study where all persons in Norway diagnosed with MPM between 1953 and 2004 (n = 738 alive per April 2004) were invited to participate. Three‐hundred‐and‐ninety patients (52.8%) responded confidentially. Mutations in CDKN2A were found in 6.9% of the respondents. Eighty‐one MPM patients (20.8%) reported that they belonged to melanoma families, and 17 (21.0%) of these harboured a CDKN2A mutation, compared to 3.2% of the nonfamilial cases. The probability of finding a CDKN2A mutation increased when the patients had three or more melanomas, or a young age of onset of first melanoma. We identified five novel CDKN2A variants (Ala57Gly, Pro81Arg, Ala118Val, Leu130Val, and Arg131Pro) and four that previously have been reported in melanoma families (Glu27X, Met53Ile, Arg87Trp, and Ala127Pro). A large deletion (g.13623_23772del10150) encompassing exon 1α and the 5′ part of exon 2 was detected in six patients with a family history of melanoma. Three patients, belonging to the same family, had the CDK4 Arg24His mutation. The frequency of CDKN2A mutations was lower than previously reported in other studies, an observation which probably is due to the population‐based design of our study. © 2007 Wiley‐Liss, Inc.
Does use of alternative medicine delay treatment of head and neck cancer? A surveillance, epidemiology, and end results (SEER) cancer registry study
Authors: Kato Ikuko , Neale Anne Victoria 
Published: November 2007

AbstractBackground.The role of complementary and alternative medicine (CAM) in cancer treatment is controversial. The aim of the study was to assess whether CAM use was associated with a delay in the initiation of conventional cancer treatment for head and neck cancer.Methods.CAM usage data were collected by mailed questionnaire for 149 incident head and neck cancer patients who were identified through the Metropolitan Detroit Cancer Surveillance System. Time from cancer diagnosis to the start of conventional cancer treatment was analyzed by the Kaplan–Meier method.Results.Overall 79% of the subjects reported use of at least 1 of the CAM items asked in the questionnaire. The time to conventional cancer treatment did not differ by prior CAM use intended to treat cancer (p =.209).Conclusions.The results of the present registry‐based study do not suggest that alternative therapy use in patients with head and neck cancer delays conventional cancer treatment. © 2007 Wiley Periodicals, Inc. Head Neck, 2008
Subgenotype diversity of hepatitis B virus American genotype F in Amerindians from Venezuela and the general population of Colombia
Authors: Devesa M. , Loureiro C.L. , Rivas Y. , Monsalve F. , Cardona N. , Duarte M.C. , Poblete F. , Gutierrez M.F. , Botto C. , Pujol F.H. 
Published: November 2007

AbstractThe objective of this study was the evaluation of the genetic diversity found in HBV circulating among Venezuelan Amerindians and the general population in Colombia. Phylogenetic analysis of the S region in 194 isolates showed that genotype F is highly predominant in Colombia and Venezuela. This might be related to the genetic background of the population. F3 is the main subgenotype which circulates in both countries. Phylogenetic analysis of 61 complete genome sequences of HBV American genotypes confirms the presence of two genotypes F and H, and 4 F subgenotypes. In Venezuela, subgenotypes F1, F2, and F3 circulate in East and West Amerindians, while only F3 was found among South Amerindians. Japreira community derived from Yucpa Amerindians around 150 years ago. However, several Japreira HBV sequences were forming a clade that can be classified as subgenotype 2b, differing from Yucpa sequences that belong mainly to subgenotype F3. The apparent absence of correlation between the phylogenetic groupings of HBV isolates with the ethnical origin in aboriginal populations might be suggesting a recent origin of HBV American subgenotypes, or a genetic drift effect. J. Med. Virol. 80:20–26, 2008. © 2007 Wiley‐Liss, Inc.
Effect of taro (Colocasia esculenta) flour addition on the functional and alveographic properties of wheat flour and dough
Authors: Njintang Nicolas Y , Mbofung Carl MF , Balaam Facho , Kitissou Pierre , Scher Joel 
Published: November 2007

AbstractBACKGROUND: Taro is a plant widely produced in tropical areas for its underground corms. Taro corms are highly perishable owing to their high moisture content. In order to limit post‐harvest losses and improve the production and consumption, production and utilization of taro flour have been envisaged. In connection with this, the incorporation of taro flour into wheat‐based products has been reported to increase their keeping quality. Before consideration is given to taro flour as a substitute for wheat in bread manufacture, it is necessary to characterize the functionality of the composite flour and dough. The present study investigated the physicochemical and alveographic properties of wheat–taro composite flour.RESULTS: Three varieties of taro flour (WCN, RIN and KWN) were incorporated into wheat flour in proportions of 10%, 20% and 30% (w/w) and the water absorption capacity (WAC), retrogradation index (RI), foam capacity (FC) and other functional properties were measured. In addition, characteristics of dough rupture pressure (P), extensibility (L), elasticity index (Ie) and strength (W) of flour made from the different composites were measured using an alveograph. The results showed that WAC significantly increased from 132% (wheat flour) to 156% (30% composite flour), while RI significantly decreased from 38% to a mean value of 22%. Principal component analysis revealed that WAC and P formed a group of variables negatively correlated with a second group made of RI, FC, W, Ie and L.CONCLUSION: Incorporating taro flour up to a level of 10% had no significant effect on the functional and alveographic properties of the flours. This suggested that in order to guarantee the quality of bread made from wheat–taro composite the level of taro addition should not exceed 10%. Copyright © 2007 Society of Chemical Industry
Keeping quality of tomato fruit by high electrostatic field pretreatment during storage
Authors: Wang Yu , Wang Baogang , Li Lite 
Published: November 2007

AbstractBACKGROUND: High electrostatic field, as a feasible and non‐chemical technique, applied to food preservation is a new area of study. The present article intensively investigated this new preservation method, together with its effects on post‐harvest physiology and quality of tomato.RESULTS: Green mature tomatoes were exposed to negative (or positive) high electrostatic field for 2 h at 20 °C and then stored for 30 days at 13 ± 1 °C, 85–90% RH. Our results indicated that negative high electrostatic field (−2 kV cm−1) could delay the decline of firmness and the change in color, total soluble sugar and titratable acidity of tomato fruit during storage. The peak of respiration and ethylene production of tomato fruit during storage were delayed by negative high electrostatic field treatment for 6 days and 3 days, respectively. Increases of malondialdehyde content and electrical conductivity in tomato fruit were inhibited significantly by negative high electrostatic field treatment during storage (P < 0.05).CONCLUSION: A high electrostatic field of − 2 kV cm−1 can be used to keep the qualities and extend the shelf‐life of tomato fruit. Further research should be highly recommended to understand the mechanisms improving the storability of tomato fruit by negative high electrostatic field. Copyright © 2007 Society of Chemical Industry
Dual‐band filter design of combined half and quarter wavelength SIRs for WLAN applications
Authors: Chen Pow‐Wen , Ho Hao‐Hung , Ho Min‐Hua , Lee Ching‐Her 
Published: November 2007

AbstractThis article presents a dual‐band bandpass filter composed of λ/2 and λ/4 stepped impedance resonators for the wireless local area network applications. The filter covers both the operating frequencies of 2.45 GHz and 5.2‐5.8 GHz. The doubly parallel‐coupling mechanism is used in the filter design to reduce the insertion losses and to gain a wider bandwidth. The cross coupling configuration and the tapped‐line I/O feed are adopted in this filter design to provide the attenuation poles for improving the signal selectivity and stopband rejection levels. Experiments were conducted to verify the circuit performance. © 2007 Wiley Periodicals, Inc. Microwave Opt Technol Lett 50: 13–15, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.22979
Reduction of numerical dispersion by optimizing second‐order cross product derivative term in the ADI‐FDTD method
Authors: Kong Ki‐Bok , Kim Jong‐Sung , Park Seong‐Ook 
Published: November 2007

AbstractWe propose a new adaptive alternating‐direction implicit finite‐difference time‐domain (ADI‐FDTD) to reduce the anisotropy in the numerical phase velocities. The proposed form has two anisotropic parameters on the first order terms of the time step and one parameter on the second order term of the time step. We introduce a new approach of reducing the error of the numerical phase velocity by controlling the three parameters. The numerical stability is discussed and compared with the previous approach of reducing the numerical dispersion. © 2007 Wiley Periodicals, Inc. Microwave Opt Technol Lett 50: 123–127, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.22991
The π‐shaped wire antenna for wideband operation
Authors: Rhee Seungyup 
Published: November 2007

AbstractThis article presents a new simple design for a π‐shaped wire antenna for helping achieve wideband operation. The geometry of the proposed antenna is similar to that of an inverted‐L antenna with two extra open wires at each side. The measured return loss results show that the bandwidth of the proposed antenna is about 38% referenced to 3 GHz, which is about four times as wide as that of the conventional inverted‐F antenna (∼8%). The experimental results of the constructed prototype are presented. © 2007 Wiley Periodicals, Inc. Microwave Opt Technol Lett 50: 156–158, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.22997
A miniaturized three‐port divider/combiner
Authors: Perrier A.‐L. , Duchamp J.‐M. , Ferrari P. 
Published: November 2007

AbstractWe propose a new topology based on a semi‐lumped complex impedance transformer for the design of miniaturized power dividers. Our design is based on an impedance transformer in the input branch and a loop in the output branches. The input impedance transformer is constituted by a transmission line loaded with a capacitor. A prototype has been realized using hybrid technology for a 1 GHz operating frequency. The electrical length of the device is 26.4°. This leads to a miniaturized device, more than three times shorter than a typical Wilkinson power divider. This divider exhibits insertion loss lower than 0.3 dB, return loss better than 20 dB and the isolation between the two output ports above 20 dB. Moreover, the low‐pass behavior of the input impedance transformer leads to a good rejection of the third harmonic. © 2007 Wiley Periodicals, Inc. Microwave Opt Technol Lett 50: 72–75, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.23008
Lowloss MIC/MMIC compatible microstrip to waveguide transition without a balun
Authors: Reljić Boro M. 
Published: November 2007

AbstractA new MIC/MMIC compatible microstrip to waveguide transition is introduced. Its main feature is balunless design, which assumes direct feeding of waveguide exciter with microstrip line—i.e., without balun. This offer: high‐frequency, wideband, and lowloss operation, using lowcost low DK substrates, and size reduction of transition more than three times. © 2007 Wiley Periodicals, Inc. Microwave Opt Technol Lett 50: 107–111, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.23012
Element‐free Galerkin method for transient electromagnetic field simulation
Authors: Liu Xiaofei , Wang Bing‐Zhong , Lai Shengjian 
Published: November 2007

AbstractElement‐free Galerkin method (EFGM) is extended to simulate transient electromagnetic field. EFGM, which is based on moving least‐square interpolations for the test and trial functions, is a promising method that needs no element connectivity data but only a set of nodes in computational domain and boundaries and does not suffer much degradation in accuracy when nodal arrangements are very irregular. EFGM is applicable to arbitrary shapes; therefore, it can solve some problems that traditional grid‐based methods cannot solve effectively in time‐domain electromagnetic field, such as thin plate problems, narrow gap problems, antenna structure optimization, etc. The numerical examples present the validation of EFGM in transient electromagnetic field and its advantages compared with traditional numerical methods. © 2007 Wiley Periodicals, Inc. Microwave Opt Technol Lett 50: 134–138, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.23017
A periodic porous‐nanostructured left‐handed material slab at optical frequencies
Authors: Chen P.‐Y. , Wu S.‐C. 
Published: November 2007

AbstractWe have proposed and theoretically investigated a left‐handed material (LHM) slab composed of porous‐nanostructed metal‐dielectric‐metal (MDM) networks for realizing negative refraction index at optical frequencies. In our design, whatever the polarization direction, provided that the electric field vector of incident EM wave is parallel to the metallic network, can “see” an equivalent LHM slab due to the symmetry and periodicity of the porous arrays. Another point needed to be highlighted is that by adjusting the periodicity of the porous arrays, a broad band of negative refraction index can be obtained. This shed the bright light on realizing negative refraction index for nanooptics and imaging applications. © 2007 Wiley Periodicals, Inc. Microwave Opt Technol Lett 50: 216–220, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.23022
Miniaturized two‐pole DC‐block semicircular‐patch bandpass filter using spur‐lines
Authors: Liu Haiwen , Sun Lingling , Knoechel Reinhard H. , Schuenemann Klaus F. 
Published: November 2007

AbstractA miniaturized two‐pole semicircular‐patch bandpass filter (BPF) with spur‐lines is introduced in this letter. Compared to the use of conventional feed lines, a reduction of 48% in the fundamental resonant frequency of the proposed BPF is achieved after adopting the orthogonal feed lines. Furthermore, the degenerate modes located at 5.14 GHz and 5.25 GHz can be excited by adding spur‐line structure. Besides, the gap between the semicircular‐patch resonators offers DC blocking. Finally, the simple and compact two‐pole BPF is demonstrated by measurements. © 2007 Wiley Periodicals, Inc. Microwave Opt Technol Lett 50: 210–213, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.23027
Generalized early‐time/late‐time evolutionary programming‐based CLEAN
Authors: Choi In‐Sik , Kim Hyo‐Tae 
Published: November 2007

AbstractA novel method, which is called generalized early‐time/late‐time evolutionary programming (EP)‐based CLEAN algorithm, is proposed for simultaneous extraction of the scattering centers and natural resonance frequencies of a radar target. This algorithm uses a duality between the temporal late‐time response and spectral early‐time response. © 2007 Wiley Periodicals, Inc. Microwave Opt Technol Lett 50: 208–210, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.23032
Wide‐band compact microwave transistor amplifier methodology and the analysis of its input‐matching mechanism using negative impedance converter
Authors: Kaya Adnan 
Published: November 2007

AbstractThe design of broadband active‐compensated amplifier system is an important problem in microwave systems. In this letter, a wide‐band high‐gain microwave transistor amplifier (MTA) design is presented with −10 dB input reflection coefficient. To achieve its characteristics, a novel input‐matching mechanism is proposed. The recognition and comprehensive interpretation of this new input‐matching mechanism is important for future development of wide‐band MTA. In this article, broad‐band impedance matching is proposed as a method for improving the matching level of amplifier. A new compensation network consisting of negative impedance converter (NIC) circuit is employed at the input of the amplifier operating at 4.2 GHz. The results show that the compensation network can improve the return loss level from −5.9 dB to −13.01 dB, and the resonant frequency can be controlled in a wide RF band. © 2007 Wiley Periodicals, Inc. Microwave Opt Technol Lett 50: 192–197, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.23046
Wideband patch antenna FED by printed meandering strip
Authors: Lai Hau‐Wah , Luk Kwai‐Man 
Published: November 2007

AbstractA printed meandering strip (PMS) is proposed for feeding a patch antenna. It is demonstrated that the impedance matching of the antenna can be further improved by using a higher order PMS. A patch antenna fed by a first order meandering strip has an impedance bandwidth of 22% [standing wave ratio (SWR) < 1.5], cross polarization level of less than −25 dB and a gain of 9 dBi. The measured impedance bandwidths of a second order PMS and a third order PMS are 12% (SWR < 1.2) and 8% (SWR < 1.1), respectively. They have an average gain of about 9 dBi and cross polarization levels are low in level. All measurements have been confirmed by simulation. © 2007 Wiley Periodicals, Inc. Microwave Opt Technol Lett 50: 188–192, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.23047
Electrically small antenna with frequency tuning circuit for wideband applications
Authors: Yoon Ick‐Jae , Park Se‐Hyun , Kim Youngeil , Joong Yoon Young 
Published: November 2007

AbstractThis study proposes the concept of frequency tuning for an electrically small antenna to be used in wideband applications in low frequencies. An electrically small antenna has too narrow bandwidth to be utilized for wideband systems. However, in such mobile TV services that the band is composed of each sub channel in VHF band, the narrow bandwidth can be appropriately utilized with wideband frequency tuning. That is, each service channel is covered by the narrow resonant band of a small sized radiator and the entire service band is satisfied by moving its frequency. To prove the idea of this study, a small helical antenna with the size of less than λ/10 is chosen as a sample and the T‐DMB service, a kind of the mobile TV services allocated to 200‐MHz band, is selected for testing. With the designed tuning circuit constituted of lumped elements and a varactor, a low impedance of the small radiator is matched to about 50 Ω and the wide bandwidth is satisfied by moving its narrow resonant frequency. The validity of the proposed antenna is also proved by the receiving measured result. © 2007 Wiley Periodicals, Inc. Microwave Opt Technol Lett 50: 244–247, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.23049
Secondary metabolites from Paronychia argentea
Authors: Braca Alessandra , Bader Ammar , Siciliano Tiziana , De Tommasi Nunziatina 
Published: November 2007

AbstractTwo new oleanane saponins (1 and 2) and one new flavonol glycoside (3) together with six known flavonoids, were isolated from the aerial parts of Paronychia argentea. Their structures were elucidated by 1D and 2D NMR experiments including 1D‐TOCSY, DQF‐COSY, NOESY, HSQC, and HMBC spectroscopy, as well as ESI‐MS analysis. Copyright © 2007 John Wiley & Sons, Ltd.
High‐resolution morphological and electrical characterisation of organic bulk heterojunction solar cells by scanning probe microscopy
Authors: Douhéret O. , Swinnen A. , Bertho S. , Haeldermans I. , D'Haen J. , D'Olieslaeger M. , Vanderzande D. , Manca J. V. 
Published: November 2007

AbstractState‐of‐the‐art organic bulk heterojunction (BH) solar cells, also called excitonic solar cells, are based on intimate mixtures of donor and acceptor organic materials of which the nanoscale morphology strongly influences both the photovoltaic performances and the stability of the device. In particular, the form and the size of the three‐dimensional (3D) interpenetrating network of donor/acceptor material is shown to be crucial for the electrical transport properties and the resulting photovoltaic properties. Powerful high‐resolution characterisation tools to locally map the morphology of these material systems are Scanning and Transmission Electron Microscopy (SEM/TEM), Atomic Force Microscopy (AFM) and Nuclear Magnetic Resonance (NMR). Yet, to correlate morphology with local electrical properties, significant progress has been made by the recent introduction of advanced Scanning Probe Microscopy (SPM) methods based on electrostatic force microscopy (EFM) and conductive atomic force microscopy (C‐AFM). EFM related methods measure the electrostatic interaction between the probe and the surface of the organic thin films, hence to derive the variations in the sample surface potential. C‐AFM based methods perform two‐dimensional (2D) current mapping of sample conductivity and local spectroscopy to analyse transversal charge transport mechanisms in the blends. In case the space charge limiting current (SCLC) regime is dominating the charge transport mechanisms, carrier mobility can also be determined. Finally, the sensitivity of C‐AFM to photovoltaic properties is reported. In this paper a review dealing with the different SPM methods currently used and the respective achievements performed on organic blends for BH solar cells is proposed. Copyright © 2007 John Wiley & Sons, Ltd.
Marked correlations in protein expression identified by proteomic analysis of human spermatozoa
Authors: de Mateo Sara , Martínez‐Heredia Juan , Estanyol Josep Maria , Domíguez‐Fandos David , Vidal‐Taboada José Manuel , Ballescà José Luis , Oliva Rafael 
Published: November 2007

AbstractThe present work was started to explore whether a correlation could be detected among proteomic expression, protamine content and DNA integrity in human sperm cells. Towards this goal, we extracted the proteins present in the sperm cells from 47 sperm samples from infertile patients and from ten semen donors, analysed each sample by 2‐D gel electrophoresis, and quantified the expression of 101 spots identified by MALDI‐TOF analysis. Additionally, the protamine content and DNA integrity were also determined. Several interesting proteins such as transcription factors, prohibitin, heat shock and proteasome proteins have been identified. We have found that the expression of an important number of proteins (58 different 2‐D spots) is correlated in independent sperm samples at high statistical significance (p<0.001 and r>0.5). Additionally, eight proteins have also been found to correlate with DNA integrity and seven with protamine content (p<0.05). To our knowledge, this is the first report describing the correlation between proteomics, DNA integrity and protamine content. It also sheds new light into the fundamental aspects of the human sperm and points to new potential proteins involved in male infertility.