bluuebunny/crossref_metadata_2025_split huggingface dataset:
Supramolecular Cobalt Cages and Coordination Polymers Templated by Anion Guests: Self‐Assembly, Structures, and Magnetic Properties
Authors: Amouri Hani , Desmarets Christophe , Bettoschi Alexandre , Rager Marie Noelle , Boubekeur Kamal , Rabu Pierre , Drillon Marc 
Published: March 2007

AbstractWe report the anion‐templated syntheses of a variety of supramolecular assemblies of CoII. Remarkably in the presence of a weakly coordinating ion such as BF4−, a discrete three‐dimensional cage [BF4⊂(BF4)2Co2(L1)4][BF4] (2) is formed with three coordinated BF4− ions, a rare example in supramolecular chemistry (L1=di(benzimidazole)‐1,4‐phenylene). Switching to stronger coordinating ions, such as NO3− or Cl−, a one‐dimensional coordination polymer [{Co(L1)(NO3)2}n] (3) and a metallomacrocycle [Co2(L1)2(Cl)4] (5) were formed, respectively. These results illustrate the powerful effect of the anion‐templating chemistry. Finally the magnetic properties of these assemblies 1 b, 2, 3, and 5 are presented and discussed.
Molecular identification and localization of cellular titin, a novel titin isoform in the fibroblast stress fiber
Authors: Cavnar Peter J. , Olenych Scott G. , Keller Thomas C. S. 
Published: March 2007

AbstractWe previously discovered a large titin‐like protein—c‐titin—in chicken epithelial brush border and human blood platelet extracts that binds α‐actinin and organizes arrays of myosin II bipolar filaments in vitro. RT‐PCR analysis of total RNA from human megakaryoblastic (CHRF‐288‐11) and mouse fibroblast (3T3) nonmuscle cells reveal sequences identical to known titin gene exon sequences that encode parts of the Z‐line, I‐band, PEVK domain, A‐band, and M‐line regions of striated muscle titins. In the nonmuscle cells, these sequences are differentially spliced in patterns not reported for any striated muscle titin isoform. Rabbit polyclonal antibodies raised against expressed protein fragments encoded by the Z‐repeat and kinase domain regions react with the c‐titin band in Western blot analysis of platelet extracts and immunoprecipitate c‐titin in whole platelet extracts. Immunofluorescent localization demonstrates that the majority of the c‐titin colocalizes with α‐actinin and actin in 3T3 and Indian Muntjac deer skin fibroblast stress fibers. Our results suggest that differential expression of titin gene exons in nonmuscle cells yields multiple novel isoforms of the protein c‐titin that are associated with the actin stress fiber structures. Cell Motil. Cytoskeleton 2007. © 2007 Wiley‐Liss, Inc.
Immunostimulatory CpG Oligonucleotides Form Defined Three‐Dimensional Structures: Results from an NMR Study
Authors: He Guangyu , Patra Amritraj , Siegmund Karsten , Peter Mirjam , Heeg Klaus , Dalpke Alexander , Richert Clemens 
Published: March 2007

AbstractThe DNA eicosamer 5′‐TCCATGACGTTCCTGATGCT‐3′ is known to stimulate the innate immune system of vertebrae. The immunostimulatory activity is based on the activation of Toll‐like receptor 9 (TLR9). While it is known that the CG dinucleotide of the eicosamer has to be unmethylated, the structural basis of the recognition of the DNA through the receptor remains unclear. Oligodeoxynucleotides containing the sequence of the eicosamer, or a portion thereof, ranging in length from hexamer to pentaeicosamer were studied by1H NMR spectroscopy. Based on two‐dimensional NMR spectra, a number of resonances could be unambiguously assigned. For all oligonucleotides, structural transitions were detected upon heating, as monitored by the line width and chemical shift of low‐field resonances. This includes the TC dinucleotide of the 5′‐terminal portion, which does not have any clear base‐pairing partners. The melting transitions, together with the NOESY cross‐peaks, demonstrate that structure formation occurs well beyond the core hexamer 5′‐GACGTT‐3′, a fact that may be important for understanding the molecular recognition by the Toll‐like receptors of the innate immune system.
The Importance of Tetrahedrally Coordinated Molecules for the Explanation of Liquid Water Properties
Authors: Ludwig Ralf 
Published: March 2007

AbstractAb initio calculations on molecular clusters and a quantum statistical model are used to probe the structure of liquid water and its anomalies. Characteristic temperature dependent mixtures of ring and three‐dimensional, voluminous water clusters provide the famous density maximum. The mixture model also reproduces the shift of the density maximum as a function of pressure and isotopic substitution. This finding is consistent with femtosecond spectroscopy data suggesting that two distinct molecular species exist in liquid water. The given structures also reproduce the oxygen–oxygen pair correlation function and the vibrational IR spectrum of liquid water. The results underline the importance of three‐dimensional, tetrahedrally coordinated structures for the understanding of water anomalies and the existence of two liquid phases in the supercooled region.
Hyperchaos from two coupled Wien‐bridge oscillators
Authors: Li Qingdu , Yang Xiao‐Song 
Published: March 2007

AbstractThis paper proposes a simple inductorless approach to generating hyperchaos by coupling two Wien‐bridge oscillators with a resistor and a diode. The whole circuit is investigated both numerically and experimentally. Also, its hyperchaotic dynamics is studied theoretically by a topological horseshoe with two‐directional expansions which provides an immediate evidence of hyperchaos. Copyright © 2007 John Wiley & Sons, Ltd.
Combined flow cytometry and confocal laser scanning microscopy for evaluation of BR96 antibody cancer cell targeting and internalization
Authors: Feridani Amir H. Iranpour , Holmqvist Bo , Sjögren Hans‐Olov , Strand Sven‐Erik , Tennvall Jan , Baldetorp Bo 
Published: March 2007

AbstractBackground:Monoclonal antibodies (mAb) are important tools in the management of tumor disease, and the discovery of antibodies with both specific cancer cell targeting and capacity to enter the cells by internalization are critical to improve the therapeutic efficacy.Method:Antibody cancer cell targeting and internalization properties of fluoroscein‐conjugated mAb made against Lewis Y (BR96) were evaluated quantitatively and qualitatively by means of flow cytometry (FCM) and confocal laser scanning microscopy (CLSM), respectively, on cells from a rat tumor cell line (BN7005‐H1D2).Results:The study demonstrated a specific binding of BR96 to LewisY (LeY) located in the cell membrane and as BR96/LeY immunocomplexes (BR96/LeY) internalized into the cytoplasm. BR96/LeY was internalized into about 15% of the cells, usually distributed throughout the cytoplasm, but also located close to the nuclei. Cytotoxic effects by BR96 were indicated, and CLSM visualized subpopulations containing cells with bound or internalized BR96/LeY that possessed morphologically pyknotic nuclei and disrupted DNA.Conclusion:The spatial‐temporal pattern by BR96 cell targeting and internalization processes of BR96/LeY into the cancer cells expressing LeY was demonstrated by FCM and CLSM. Used together, the FCM and CLSM techniques provide a valuable tool for preclinical analyses of antibody targeting and their capacities as carriers of cytotoxic conjugates for the use in cancer therapy. © 2007 International Society for Analytical Cytology
Evaluation of malignant and benign gastric biopsy specimens by mRNA expression profile and multivariate statistical methods
Authors: Galamb Orsolya , Sipos Ferenc , Molnar Bela , Szoke Dominika , Spisak Sandor , Tulassay Zsolt 
Published: March 2007

AbstractBackground:mRNA expression array and multivariate statistical analysis of gastric biopsies can yield insight into the molecular biology basis of local alterations, supporting expression‐based identification of morphological alterations.Methods:From 11 patients with erosive gastritis(EG), 5 with adenocarcinoma (GC), 11 with atrophic gastritis (AG) gastric biopsies were collected, total RNA isolated, T7 amplification and expression analysis of 1047 mRNAs was performed using commercial glass arrays (Clontech, USA). After microarray quality control, applicable data were available from 7 EG, 4 GC, and 5 AG. Multivariate statistical and cell functional analysis were performed. Real‐time RT‐PCR and immunohistochemistry were used for validation.Results:GC was characterized by overregulated v‐raf, v‐erb‐a, BCL2‐associated‐ athanogene, immediate‐early‐response‐3, Polo‐like kinase, CDK‐2, cyclin‐C, Pin1 genes, and downregulated ADP‐ribosyltransferase, sialophorin and DCC. AG cases had increased PDGF‐receptor, TGF‐β‐receptor‐3, and decreased death‐associated‐protein‐3, β‐1‐catenin, topoisomerase‐1 levels. In EG upregulation of IGF‐receptor‐1, CD9, transferrin receptor, integrins, and underexpression of keratin‐5, caspase‐4 was found. Discriminant analysis could reclassify all samples correctly using four parameters.Conclusions:mRNA expression array analysis of gastric biopsies yields previously known and new data in the evaluation of local gastric alterations. © 2007 Clinical Cytometry Society
On the application of forking nodes to product‐form queueing networks
Authors: Elhafsi Essia H. , Molle Mart , Manjunath D. 
Published: March 2007

AbstractWe define a ‘forking node’ as a service centre with one input feeding two outputs (each served by its own queue) under the control of an internal path‐selection (PS) policy. We assume that both outputs lead to paths through which a packet reaches its final destination. However, the mean downstream delays on the two paths may be different and the PS policy should favour the path with the lower downstream delay. Using simulation, we compare the performance of this system under a variety of random, deterministic, state‐dependent PS policies, including threshold‐based and join‐shortest‐queue with bias (JSQ + b). We show that JSQ + b has better performance than the other alternatives. Moreover, if the input process to the forking node is Poisson, standard time series analysis techniques show that its two outputs are very close to being independent Poisson processes. Thus, if we find an accurate and efficient ‘offline’ analytical performance model for JSQ + b forking node, we can extend the applicability of product‐form queueing networks to include such forking nodes. For this reason, we present several ways of modelling the performance of a JSQ + b node, using bounds, and compare their results on example networks. We establish a closed‐form expression relating the bias b and the delays of the downstream paths. Copyright © 2007 John Wiley & Sons, Ltd.
Anorexia nervosa treatment: A systematic review of randomized controlled trials
Authors: Bulik Cynthia M. , Berkman Nancy D. , Brownley Kimberly A. , Sedway Jan A. , Lohr Kathleen N. 
Published: March 2007

AbstractObjective:The RTI International‐University of North Carolina at Chapel Hill Evidence‐based Practice Center (RTI‐UNC EPC) systematically reviewed evidence on efficacy of treatment for anorexia nervosa (AN), harms associated with treatments, factors associated with treatment efficacy, and differential outcome by sociodemographic characteristics.Method:We searched six major databases for studies on the treatment of AN from 1980 to September 2005, in all languages against a priori inclusion/exclusion criteria focusing on eating, psychiatric or psychological, or biomarker outcomes.Results:Thirty‐two treatment studies involved only medications, only behavioral interventions, and medication plus behavioral interventions for adults or adolescents. The literature on medication treatments and behavioral treatments for adults with AN is sparse and inconclusive. Cognitive behavioral therapy may reduce relapse risk for adults with AN after weight restoration, although its efficacy in the underweight state remains unknown. Variants of family therapy are efficacious in adolescents, but not in adults.Conclusion:Evidence for AN treatment is weak; evidence for treatment‐related harms and factors associated with efficacy of treatment are weak; and evidence for differential outcome by sociodemographic factors is nonexistent. Attention to sample size and statistical power, standardization of outcome measures, retention of patients in clinical trials, and developmental differences in treatment appropriateness and outcome is required. © 2007 by Wiley Periodicals, Inc. Int J Eat Disord 2007
Bulimia nervosa treatment: A systematic review of randomized controlled trials
Authors: Shapiro Jennifer R. , Berkman Nancy D. , Brownley Kimberly A. , Sedway Jan A. , Lohr Kathleen N. , Bulik Cynthia M. 
Published: March 2007

AbstractObjective:The RTI International‐University of North Carolina at Chapel Hill Evidence‐based Practice Center systematically reviewed evidence on efficacy of treatment for bulimia nervosa (BN), harms associatedwith treatments, factors associated with treatment efficacy, and differential outcome by sociodemographic characteristics.Method:We searched six major databases published from 1980 to September 2005 in all languages against a priori inclusion/exclusion criteria; we focused on eating, psychiatric or psychological, and biomarker outcomes.Results:Forty‐seven studies of medication only, behavioral interventions only, and medication plus behavioral interventions for adults or adolescents met our inclusion criteria. Fluoxetine (60 mg/day) decreases the core symptoms of binge eating and purging and associated psychological features in the short term. Cognitive behavioral therapy reduces core behavioral and psychological features in the short and long term.Conclusion:Evidence for medication or behavioral treatment for BN is strong, for self‐help is weak; for harms related to medication is strong but either weak or nonexistent for other interventions; and evidence for differential outcome by sociodemographic factors is nonexistent. Attention to sample size, standardization of outcome measures, attrition, and reporting of abstinence from target behaviors are required. Longer follow‐up intervals, innovative treatments, and attention to sociodemographic factors would enhance the literature. © 2007 by Wiley Periodicals, Inc. Int J Eat Disord 2007
New Ternary Complexes of Copper(II) with 2,2′‐Bipyridine (Bpy) and Phosphocholine (PCh–) or the Quaternary 1‐(2‐Phosphonomethoxy)ethyl Derivative of 2,4‐Diaminopyrimidine (PMEDAPy–)
Authors: Fernández‐Botello Alfonso , Escuer Albert , Solans Xavier , Font‐Bardía Mercè , Holý Antonin , Sigel Helmut , Moreno Virtudes 
Published: March 2007

AbstractThe polynuclear CuII complexes [Cu4Cl2(bpy)4(PCh–)2](ClO4)4·H2O (1) and [Cu6(bpy)6(PMEAPy–)4](ClO4)8·2H2O (2), where bpy = 2,2′‐bipyridine, PCh– = phosphocholine {[2‐(phosphonooxy)ethyl]trimethylammonium} and PMEDAPy– = 1‐[2‐(phosphonomethoxy)ethyl]‐2,4‐diaminopyrimidine, have been synthesized and characterized by X‐ray single‐crystal analysis. Compound 1 crystallizes in the triclinic system (P‐1 space group) and consists of tetranuclear CuII units, which are threefoldly bridged by μ3‐O,O′,O″‐phosphate groups in a square arrangement around the copper atoms. Complex 2 crystallizes in the monoclinic system (P21/c space group) and consists of hexanuclear CuII units containing the same kind of μ3‐phosph(on)ate bridges like 1 and in addition μ4‐O,O′,O″,O″‐phosphonate bridges. The topology of compound 2 can be envisaged as two triangular subunits linked by means of a double Cu–O–Cu bridge provided by the μ4‐phosphonate unit. Magnetic susceptibility measurements of the two complexes in the temperature range of 2–300 K show weak antiferromagnetic couplings mediated by the phosph(on)ate bridges. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
Complexation of Molybdenum(VI) with Bis(3‐hydroxy‐4‐pyridinone)amino Acid Derivatives
Authors: Santos M. Amélia , Gama Sofia , Pessoa João Costa , Oliveira M. Conceição , Tóth Imre , Farkas Etelka 
Published: March 2007

AbstractThe molybdenum(VI) binding properties of a series of 3‐hydroxy‐2‐methyl‐4‐pyridinones (3,4‐HP), namely bis(3,4‐HP)chelators, were investigated in solution and as solids; in particular, the complexation of MoVI with iminobis{acetyl[1‐(3′‐aminopropyl)‐3‐hydroxy‐2‐methyl‐4‐pyridinone]}, IDAPr(3,4‐HP)2, and ethylenediamino‐N,N′‐bis(methylcarboxyl)‐N,N′‐bis{acetyl[1‐(3′‐aminopropyl)‐3‐hydroxy‐2‐methyl‐4‐pyridinone]}, EDTAPr(3,4‐HP)2, as well as three model compounds: 1,2‐dimethyl‐3‐hydroxy‐4‐pyridinone (DFP), iminodiacetic acid (IDA), and ethylenediaminodiacetic acid (EDDA). Solution studies show that the complexation occurs at low pH values by the coordination modes of the hydroxypyridinone moiety, and with the formation of bischelated MoO22+ species. As the pH is increased, hydrolytic processes start with the formation of monochelated MoO3 complexes and is followed by the total recovery of the free ligand, at pH > 8 for most of the systems, but at pH 10 for EDTAPr(3,4‐HP)2. The obtained solid molybdenum complexes showed evidence for the presence of mononuclear species in solution, whereas the dinuclear species, (MoO2)2EDTAPr(3,4‐HP)2, were only detected for the EDTA derivative. Aqueous solution studies were performed by pH–potentiometry, spectrophotometry, 1H NMR and 17O NMR spectroscopy, and solid complex species were characterized by elemental analysis, IR spectroscopy, and ESI‐MS.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
The Iminophosphorane‐Phosphane Ph2PC6H4OC6H4PPh2=NP(O)(OPh)2: Synthesis, Reactivity, and Catalytic Activity in Suzuki Cross‐Coupling and the Homogeneous Hydrogenation of Olefins
Authors: Venkateswaran Ramalingam , Balakrishna Maravanji S. , Mobin Shaikh M. 
Published: March 2007

AbstractThe iminophosphorane‐phosphane ligand Ph2PC6H4OC6H4PPh2=NP(O)(OPh)2 (1) has been synthesized by partial imination of bis[2‐(diphenylphosphanyl)phenyl] ether (DPEphos) with phosphoryl azide (PhO)2P(O)N3. A similar reaction in a 1:2 stoichiometry affords the bis(iminophosphorane) O{C6H4PPh2=NP(O)(OPh)2}2 (2). The chalcogen derivatives O{C6H4P(E)Ph2}2 [E = S (3) and Se (4)] and Ph2P(E)C6H4OC6H4PPh2=NP(O)(OPh)2 [E = S (5) and Se (6)] are also synthesized by treating DPEphos and 1 with elemental sulfur and selenium, respectively. The mononuclear complexestrans‐[MCl2{κ1‐P‐Ph2PC6H4OC6H4PPh2=NP(O)(OPh)2}2][M = Pt (7) Pd (8)] and trans‐[Rh(CO)Cl{κ1‐P‐Ph2PC6H4OC6H4PPh2=NP(O)(OPh)2}2] (12) are prepared by the reaction of 1 with [Pt(COD)Cl2], [Pd(COD)Cl2], and [{Rh(CO)2Cl}2], respectively. Treatment of 1 with [Pd2(dba3)] (dba = dibenzylideneacetone) affords the mononuclear complex [Pd0{κ2‐P,O‐Ph2PC6H4OC6H4PPh2=NP(O)(OPh)2}2] (9) in which ligand 1 coordinates through its P and O centers in a κ2‐P,O chelating fashion. The monocoordinated AuI complex [AuCl{κ1‐P‐Ph2PC6H4OC6H4PPh2=NP(O)(OPh)2}] (10) has been prepared by the reaction of 1 and [AuCl(SMe2)] and its structure has been confirmed by X‐ray crystallography. The reaction of 1 with [{Rh(COD)Cl}2] in the presence of AgOTf affords the cationic RhI complex cis‐[Rh(COD){κ2‐P,O‐Ph2PC6H4OC6H4PPh2=NP(O)(OPh)2}][OTf] (11). The catalytic activity of the Pd0 complex 9 has been investigated in Suzuki cross‐coupling reactions. Homogeneous catalytic hydrogenation of olefins has also been studied using the cationic RhI complex 11.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
N–H Group Transfer and Oxidative Addition Chemistry Promoted by Isolable Bis(cyclopentadienyl)titanium Sandwich Complexes
Authors: Hanna Tamara E. , Lobkovsky Emil , Chirik Paul J. 
Published: March 2007

AbstractAddition of propylenimine (2‐methylaziridine) to the bis(cyclopentadienyl)titanium sandwich complexes, (η5‐C5Me4R)2Ti (R = iPr, SiMe3), resulted in rapid [NH] group transfer followed by C–H activation of a cyclopentadienyl methyl group to yield the corresponding cyclometalated titanocene amido compounds. Exposure of these molecules to 4 atm of H2 at 55 °C resulted in hydrogenolysis of the metal–carbon bond to form the titanium amido hydride compounds, (η5‐C5Me4R)2Ti(NH2)H. Deuteriolysis with DCl gas confirmed exclusive cyclometalation from the positions adjacent to the isopropyl and trimethylsilyl substituent. Oxidative addition of the N–H bonds of amines has also been observed. Addition of NH3 to either (η5‐C5Me4SiMe3)2Ti or (η5‐C5Me4iPr)2Ti yielded the corresponding titanocene amido hydrides along with the titanocene(III) amides, (η5‐C5Me4R)2TiNH2, arising from formal deprotonation by unreacted sandwich from the putativetitanocene ammonia complex.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
The First Copper Complexes Bearing the 1,3,5‐Triaza‐7‐phosphaadamantane (PTA) Ligand
Authors: Kirillov Alexander M. , Smoleński Piotr , Guedes da Silva M. Fátima C. , Pombeiro Armando J. L. 
Published: March 2007

AbstractThe CuI compound [Cu(PTAH)4](NO3)5 (1) {PTAH = N‐protonated form of 1,3,5‐triaza‐7‐phosphaadamantane (PTA)} was easily prepared by reacting hydrated Cu(NO3)2 and PTA in aqueous acidic solution at room temperature. Further treatment of 1 with sodium hydroxide in water led to an unprotonated PTA derivative [Cu(PTA)4](NO3) (2). Both compounds are water‐soluble and air‐stable, and were characterized by IR, 1H‐, 13C{1H}‐, 31P{1H}‐ and 63Cu NMR spectroscopy, FAB‐MS(+), elemental and single‐crystal X‐ray diffraction structural analyses. They exhibit a nearly regular tetrahedral coordination environment about each copper centre filled by the phosphorus atoms of the four PTAH/PTA moieties, which show distinct and unusual geometrical arrangements if viewed along the P–Cu bonds. The 31P{1H}‐ and 63Cu NMR spectra of 2 in D2O solution show spin coupling between the 31P and 63Cu nuclei at room temperature. These compounds represent the first examples of Cu complexes bearing PTA or any derived ligand with a cagelike PTA core and expand the restricted family of aqua‐soluble copper phosphane complexes. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
Order and Disorder in Cluster Phases – The Case of La≈0.7(Al≈0.1I≈0.9)
Authors: Kienle Lorenz , Oeckler Oliver , Weber Thomas , Duppel Viola , Mattausch Hansjürgen , Simon Arndt 
Published: March 2007

AbstractThe structure of the new partially ordered cluster phase La0.69(1)(Al0.12(1)I0.88(1)) was determined by a combined methodical approach of electron microscopy techniques and X‐ray diffraction. The structure is derived from the Gd3CCl3‐type and ca. 50 % of the cluster positions in this structure type are occupied. The majority of the clusters are condensed via common edges, however, the degree of cluster condensation is low. The arrangement of neighboring clusters is comparable to chemically related, but strongly disordered cluster phases. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)