bluuebunny/crossref_metadata_2025_split huggingface dataset:
A sociodemographic, clinical study of patients with venous ulcer
Authors: Abbade Luciana P. Fernandes , Lastória Sidnei , De Almeida Rollo Hamilton , Ometto Stolf Hamilton 
Published: December 2005

AbstractBackground  Venous ulcer is the most serious consequence of chronic venous insufficiency and is responsible for almost 70% of chronic leg ulcers. The main purpose of this research was to describe social, demographic and clinical characteristics of patients with venous ulcers and to identify some professional repercussions of this pathology.Subjects and methods  We evaluated patients with a clinical picture compatible with venous ulcer. The sociodemographic characteristics of the patients, and the clinical characteristics and professional repercussions of the pathology were studied. We used the ankle‐brachial index to identify associated arterial disease. The body mass index (BMI) was used for the classification of the nutritional condition of the patients.Results  A total of 120 patients were included in the study (90 females and 30 males; 80.8% White; 44.2% > 60 years old). Ninety‐one per cent of the patients had been in education for less than 4 years, and 89.7% were on the poverty line. Thirty‐five per cent were retired, 2.5% were receiving government help due to disease and 4.2% were unemployed. About 16% of patients were out of work due to the disease, and 49.2% presented some degree of disability in terms of work tasks. The ulcer area was less than 30 cm2 in 69.1% of patients. The first ulcer episode occurred in 13.4 years on average, and 64.2% of patients had recurrent episodes. Females presented on average 5.65 pregnancies, and 75.4% of patients were overweight.Conclusion  Venous ulcer occurred mainly in the low‐income population, who presented with little formal education. Generally, the ulcers were present for a long time and were recurrent, with repercussions for the capabilities of patients to work.
Effect of ethnicity on the risk of developing nonmelanoma skin cancer following long‐term PUVA therapy
Authors: Murase Jenny E. , Lee Ernest E. , Koo John 
Published: December 2005

AbstractBackground  Research demonstrating an increased incidence of skin cancer with psoralen plus ultraviolet A (PUVA) therapy has reflected the Caucasian experience. Our objective was to review the literature on skin cancer risk associated with long‐term PUVA therapy in non‐Caucasians.Methods  Our analysis included 4294 long‐term PUVA patients in Japan, Korea, Thailand, Egypt, and Tunisia with a follow‐up period of at least 5 years.Results  The relative risk of PUVA patients developing nonmelanoma skin cancer relative to general dermatology outpatients was 0.86 [CI 0.36–1.35].Conclusions  There does not appear to be an increased risk of nonmelanoma skin cancer with long‐term PUVA therapy in Asian and Arabian‐African populations. Therefore, in phototherapy risk assessment, it is important to consider the patient's skin phototype and the potential protection that more pigmented skin may confer.
Association of HLA‐DQA1 and DQB1 genes with vitiligo in Chinese Hans
Authors: Yang Sen , Wang Ji‐Yun , Gao Min , Liu Hong‐Sheng , Sun Liang‐Dan , He Ping‐Ping , Liu Jiang‐Bo , Zhang An‐Ping , Cui Yong , Liang Yan‐Hua , Wang Zai‐Xing , Zhang Xue‐Jun 
Published: December 2005

AbstractBackground  Vitiligo is an acquired depigmentary disorder of the skin and hair which results from selective destruction of melanocytes. Serological typing and genotyping of human leukocyte antigen (HLA) have shown discrepancies in HLA associations with vitiligo in different ethnic populations.Methods  Polymerase chain reaction sequence‐specific primer (PCR‐SSP) method was used to analyze the distribution of HLA‐DQA1 and ‐DQB1 alleles among 187 patients with vitiligo and 273 healthy controls through Epi Info version 6 package (Centers for Disease Control and Prevention, Atlanta, GA, USA).Results  The frequencies of HLA‐DQA1*0302 (OR = 1.98, Pc < 0.01), ‐DQB1*0303 (OR = 3.14, Pc < 0.001), and ‐DQB1*0503 (OR = 3.36, Pc < 0.05) alleles were significantly increased in patients with vitiligo compared with controls, and HLA‐DQA1*0501 (OR = 0.40, Pc < 0.01) allele frequency was highly decreased. HLA‐DQA1*0302 (OR = 5.19, Pc < 0.001), ‐DQA1*0601 (OR = 2.95, Pc < 0.05), ‐DQB1*0303 (OR = 4.50, Pc < 0.001), and ‐DQB1*0503 (OR = 6.69, Pc < 0.001) alleles were positively associated, whereas HLA‐DQA1*0501 (OR = 0.05, Pc < 0.001) allele was negatively associated with childhood vitiligo patients, and HLA‐DQB1*0303 (OR = 2.76, Pc < 0.001) allele was positively associated with adult vitiligo patients compared with controls. The frequency of HLA‐DQB1*0303 (OR = 3.72, Pc < 0.001) allele was significantly increased in localized vitiligo patients vs. controls, whereas HLA‐DQA1*0302 (OR = 2.47, Pc < 0.01), ‐DQB1*0303 (OR = 2.67, Pc < 0.01), and ‐DQB1*0503 (OR = 4.46, Pc < 0.01) allele frequencies were significantly increased and ‐DQA1*0501 (OR = 0.27, Pc < 0.01) allele frequency was highly decreased in generalized vitiligo patients.Conclusions  HLA‐DQA1*0302, ‐DQA1*0601, ‐DQB1*0303, and ‐DQB1*0503 alleles could be susceptible alleles of vitiligo, while HLA‐DQA1*0501 allele could be a protective allele in Chinese Hans. There may be different genetic backgrounds between vitiligo patients of childhood and adult, localized and generalized.
Giant annular dermatomyofibroma
Authors: Ku Lap Shing , Chong Lai Yin , Yau Ko Chiu 
Published: December 2005

A 74‐year‐old lady presented with a painful giant annular abdominal plaque for a duration of 2 years. The plaque developed from a cholecystectomy scar and extended peripherally around it. The patient had had a cholecystectomy for gallstones 10 years previously. She was a diabetic on oral hypoglycaemic agents and had no history of radiotherapy. Physical examination showed a tender well‐demarcated annular erythematous keloid‐like plaque, measuring 13 cm × 15 cm, surrounding a cholecystectomy scar. Another smaller oval plaque, measuring 3 cm × 2 cm, was found on the left side of the abdomen (Fig. 1). The initial clinical diagnosis was dermatofibrosarcoma protuberan (DFSP). A deep incisional biopsy including subcutaneous fat was performed under local anesthesia for pathological examination. Histologically, there was a plaque‐like lesion involving the upper reticular dermis but not extending to the subcutaneous fat. The lesion showed proliferation of spindle‐shaped cells arranged in intersecting fascicles and appeared parallel to the skin surface. Only a vague storiform pattern was seen at the edges. The cells had relatively uniform elongated nuclei and mitosis was not seen. The overlying epidermis showed mild hyperplasia with pigmentation of the basal layer (Fig. 2). Smooth muscle actin was positive (Fig. 3), desmin was negative and CD34 was negative. The final diagnosis was dermatomyofibroma (DMF). Extra‐abdominal fibromatosis was unlikely because broad elongated fascicles among collagenous stroma were not evident, while intersecting fascicles parallel to the skin surface were typical of DMF. The smaller plaque on her left abdomen was excised and gave similar histological and staining results. The giant annular plaque was not excised as the patient refused further surgery. She has since been closely monitored.A well‐demarcated annular erythematous keloid‐like 11 cm × 13 cm plaque surrounding a cholecystectomy scar; a smaller oval plaque measuring 3 cm × 2 cm was found on the left side of the abdomenimageThe lesion shows proliferation of spindle‐shaped cells arranged in intersecting fascicles; most appear parallel to the skin surface. Only a vague storiform pattern is seen (H&E, ×10)imageImmunohistochemical staining with actin shows moderate cytoplasmic staining. Internal positive control is demonstrated by staining of the blood vessel pericytes (SMA, ×5)image
Scrotal hair in identical twin infants
Authors: Leung Alexander K. C. , Hegde Hardally R. , Stephure David K. 
Published: December 2005

Scrotal hair in infancy is extremely rare. We report identical twins who had scrotal hair at 1 month of age. The condition is likely owing to hypersensitivity of the scrotal hair follicles to transiently elevated androgen levels in the first few months of life. Our patients are the youngest reported in the literature. Most cases are sporadic. The present cases suggest that the condition can be familial.
Lack of correlation between Helicobacter pylori infection and autologous serum skin test in chronic idiopathic urticaria
Authors: Başkan Emel Bülbül , Türker Tugba , Gülten Macit , Tunali Sükran 
Published: December 2005

AbstractBackground  There are controversial reports about the direct role of Helicobacterpylori infection in chronic idiopathic urticaria. The indirect role of H. pylori infection in the induction of pathogenetic antibodies is not fully elucidated either. This study aims to reveal the association of H. pylori infection with autologous serum skin test positivity in chronic idiopathic urticaria (CIU) patients.Methods  A total of 47 patients (35 women, 12 men, age range 17–65 years) diagnosed as CIU were included in the study. Autologous serum skin test was performed on all patients. The patients were examined with a commercially available ELISA test for H. pylori‐specific antibodies. Gastroscopy with mucosal biopsy and rapid urease tests were proposed to verify the presence of H. pylori infection.Results  Helicobacter pylori infection was detected in 33 of the 47 patients (70%). No significant relation was found between the autologous serum skin test positivity and the serological and histopathological presence of H. pylori infection.Conclusion  The results of our study suggest that chronic H. pylori infection does not appear to have a role in the induction of autoantibodies in CIU.
Prevalence and risk factors for tinea pedis in Israeli soldiers
Authors: Cohen A. D. , Wolak A. , Alkan M. , Shalev R. , Vardy D. A. 
Published: December 2005

AbstractBackground  Tinea pedis is a common infection in soldiers. However, prevalence and risk factors for tinea pedis in soldiers were investigated in only a few studies.Objectives  To investigate the prevalence and risk factors for tinea pedis in Israeli soldiers.Methods  A cross‐sectional study including interviews, clinical skin examination and mycological tests was performed in Israeli soldiers. The presence of tinea pedis was assessed using the Athlete's Foot Severity Index (AFSI), a scoring system that was developed in order to evaluate the presence and severity of tinea pedis. In soldiers with clinical evidence of tinea pedis (AFSI > 1), scrapings were taken for direct microscopic examination (20% KOH preparation) and fungal culture. Statistical analyses were performed using chi‐square or Fisher's exact test for dichotomous variables (as needed), or t‐tests for continuous variables. Logistic regression was used for multivariate analyses of dichotomous variables.Results  Two hundred and twenty‐three soldiers were included in the study: 205 men (91.9%) and 18 women (8.1%). Mean age was 19.6 years (SD 1.0 year). Clinical point prevalence was 60.1%. Mycological point prevalence was 27.3%. Further analyses were performed using the clinical point prevalence. Univariate analyses demonstrated that the prevalence of tinea pedis varied with the setting of military training (basic training: 70.3%, advanced infantry training: 81.5%, armor commander training: 56.4% and armor officer training: 34.8%) and was associated with male gender, frequency of sock changes and the length of military service. A multivariate analysis demonstrated that tinea pedis was associated with the setting of the military training (OR 1.6, 95% CI 1.2–2.1) and male gender (OR 4.3, 95% CI 1.4–13.8); however, there was no association with hygiene measures (e.g. frequency of changing socks or sleeping with socks) or the length of military service.Conclusion  Tinea pedis is highly prevalent in Israeli soldiers. Association of tinea pedis with the setting of military training suggests that contagious spread may be an important risk factor. We suggest that environmental interventions should be planned to in order to decrease the morbidity of tinea pedis among soldiers.
Profile of acne patients in the Philippines requiring a second course of oral isotretinoin
Authors: Haryati Indra , Jacinto Sylvia S. 
Published: December 2005

AbstractBackground  Oral isotretinoin (OI) is currently the gold standard in the treatment of moderately severe to severe acne vulgaris. Approximately 50–85% of patients achieve permanent cure with one course based on 1.0–2.0 mg/kg/body weight. It has been shown that a dosage of less than 1 mg/kg/body weight predisposed to noncure and required a second course for a permanent cure.Objective  Purpose of this study was to describe the profile of acne patients in the Philippines requiring a second course of OI.Methods  Charts of acne vulgaris patients given OI in a private dermatology clinic (SSJ) over a period of 10 years were reviewed and analyzed. All patients were given a total dose of 1 mg/kg/body weight (cumulative total dose of 120 mg/kg/body weight).Result  Of 240 patients taking OI included in the study, 193 completed the entire course. One hundred and 43 (59.6%) were cured after one course and required no further therapy (control group: CG), 42 (17.5%) experienced relapse and were treated with topical therapy, and eight (3.3%) relapsed and required oral antibiotic plus topical therapy. Only 47 patients (19.6%) required a second course of OI therapy (study group: SG). There was no difference between the two groups in age, sex, severity, and location of lesions. Two factors were found to be of statistically significant difference: Total dose actually taken with 103.5 mg/kg/body weight for the SG vs. 118.55 mg/kg/body weight for the CG. Median duration of treatment was 6.7 months for the SG vs. 7.41 months for the CG, respectively.Conclusion  The profile of acne patients in the Philippines requiring a second course of OI is seen in those taking a mean cumulative dose (actual total dose) less than 120 mg/kg/body weight, with a mean actual duration of 6.7 months.
Distribution, biomass and primary production of an Ahnfeltia tobuchiensis (Ahnfeltiales, Rhodophyta) population in the Bay of Izmena, Kunashir Island
Authors: Cherbadgy Ivan I. , Popova Ludmila I. 
Published: December 2005

SUMMARYRegularities of distribution and primary production of an Ahnfeltia tobuchiensis (Kanno et Matsubara) Mak. population, an agar‐containing red alga, were studied in the Bay ot Izmena. Experiments were conducted in a flow‐through system under conditions similar to algal habitats. The population of A. tobuchiensis unattached to the ground may be from a few centimeters to as much as 1 m thick. It has been shown that only the upper part of a stratum 15–20 cm thick receives a sufficient amount ot light to realize its production potential. While 15–20% of photosynthetically active radiation (PAR) of that falling on the water surface reaches the stratum surface, only 0.1% of PAR from that falling on the water surface penetrates through stratum 15 cm thick. It has been shown for A. tobuchiensis that its photosynthetic rate curve during the daytime mainly follows the PAR intensity curve. The highest values of photosynthetic rate have been measured in the afternoon when PAR reaches its maximum. It is noted that a stratum 15–20 cm thick has peak values ot net primary production (NPP) which averages 3.2 g C m−2 day−1. The total area of A. tobuchiensis population was 23.4 km2, and its biomass was 125 000 tons in this area. On average, the NPP of the A. tobuchiensis population made up in summer and in autumn was 46.8 and 25.0% of its biomass, respectively.
Porphyra monospore system (Bangiales, Rhodophyta): A model for the developmental biology of marine plants
Authors: Kitade Yukihiro , Taguchi Go , Shin Jong‐Ahm , Saga Naotsune 
Published: December 2005

SUMMARYWe have developed an experimental system of cohort monospores from clonal culture of leafy gametophytes in Porphyra yezoensis Ueda (strain TU‐1). This system is quite different from traditional systems for algal protoplast experimentation, which require expensive enzymatic treatment and utilize an ineffective method of preservation. Cohort monospores were obtained by utilizing a mode of asexual reproduction in the culture strain (monospores) and artificial regulation (thallus length, temperature, light, etc.) of monospore release. When the leafy gametophytes that formed monospores were frozen at ‐ 20°C in a cryoprotective solution composed of 5% DMSO and 5% dextran in 100% seawater, about 98% survived for 3 months. When stored at 5°C without cryoprotectants, these leafy gametophytes could be kept without monospore release for 1 week. Maximum monospore yield was about 3000 spores per 100 gametophytes, and germination rate was about 70%, This system will accelerate developmental biology studies in Porphyra.
Chemotaxonomy of planktonic cyanobacteria based on non‐polar and 3‐hydroxy fatty acid composition
Authors: Li Renhui , Yokota Akira , Sugiyama Junta , Watanabe Masayuki , Hiroki Mikiya , Watanabe Makoto M. 
Published: December 2005

SUMMARYTwenty‐eight axenio planktonic cyanobacterial strains (10 Microcystis, three Oscillatoria, one Spirulina, one Aphanizomenon, 13 Anabaena) were investigated for their fatty acid composition by measurement of non‐polar and hydroxy fatty acids. No 2‐hydroxy fatty acids were detected in any strain, but 3‐hydroxy fatty acids were detected in minor quantities in 24 strains. The highest portion of total fatty acids were non‐polar fatty acids. Qualitative and quantitative analyses of 3‐hydroxy fatty acids showed no taxonomic value in these strains, while the type of non‐polar fatty acid composition was shown to be consistent within Microcystis and Anabaena strains, distinguishing them as type 4, characterized by the presence of 18:4, and type 2, characterized by 18:3 (α) of the Kenyon‐Murata system. Two Oscillatoria agardhii Gomont strains were also included in the type 2 group due to the presence of 18: 3 (α), but the difference in characteristics of 16:2 and 16:3 between O. agardhii and Anabaena further divided type 2 into two subgroups: type 2A for Anabaena and type 2B for O. agardhii. A simplified unweighted pair group method with arithmetic averages (UPGMA) dendrogram demonstrated that the classification of 28 strains (Microcystis spp., Anabaena spp., Aphanizomenon flos‐aquae (Lemmermann) Ralfs f. gracile (Lemmermann) Elenkin, O. agardhii and Spirullnasubsalsa Oersted ex Gomont based on numerical analysis of non‐polar fatty acids corresponded to morphological species criteria, suggesting that non‐polar fatty acid composition is a valuable chemical marker in the taxonomy of planktonic cyanobacteria. However, the fatty acid composition in Oscillatoria raciborskii is similar to that of Microcystis and very different from that of O. agardhii, suggesting its special position in Oscillatoria and the chemical diversity in the genus Oscillatoria.
A taxonomic study of JapaneseScytosiphon(Scytosiphonales, Phaeophyceae), including two new species
Authors: Kogame Kazuhiro 
Published: December 2005

SUMMARYMorphological and culture studies were carried out on the genusScytosiphon(Scytosiphonales, Phaeophyceae) growing in Japan. Morphologies of plurilocular zo‐idangia and sporophytic thalli were found to be useful as taxonomic characters. Two types of plurilocular zo‐idangial sori were recognized: (i) loosely coherent plurilocular zoidangia without a cuticular layer (loose type); (ii) tightly coherent plurilocular zoidangia with a cuticular layer (coherent type). The sporophytic thallus morphology was different among species in general appearance (tufted or discoid), degree of cohesion of erect filaments, and presence or absence of paraphyses. Two new species are described,Scytosiphon gracilissp. nov. andScytosiphon tenellussp. nov,Scytosiphon gracilisis distinguished from other species by a thin medullary layer, coherent plurilocular zoidangia, no ascocysts associated with plurilocular zoidangia, and Compsonema‐like sporophytic thalli.Scytosiphon tenellusis characterized by a thin medullary layer, coherent plurilocular zoidangia, ascocysts among plurilocular zoidangial sori, andStragularia‐like sporophytic thalli.Scytosiphon lo‐mentaria(Lyngbye) Link is characterized by a constricted gametophytic thallus, loose plurilocular zoidangia, the presence of ascocysts, and sporophytic thaili identified withMicrospongium gelatlnosumReinke.
Porphyra lilliputiana sp. nov. (Bangiales, Rhodophyta): A diminutive New Zealand endemic with novel reproductive biology
Authors: Nelson Wendy A. , Knight Glenys A. , Hawkes Michael W. 
Published: December 2005

SUMMARYA new species of Porphyra, Porphyra lilliputiana, is described for the New Zealand region. This species is very small ([5] 10–20 [35] mm) and is found growing epiphytically, epilithically and epizoically on upper inter‐tidal shores of moderate exposure. Field‐collected material of P. lilliputiana possessed archeosporangia, endosporangia, spermatangia and zygotosporangia. In culture, archeospores vi/ere released and germinated to form thalli. Endosporangia either developed directly into thalli or released endospores which individually formed thalli. Zygotospores developed into the concho‐celis phase, which formed conchosporangia. Released conchospores formed thalli. This species is distinguished by its small size, arrangement of reproductive cells, occurrence of endosporangia, dentate margin and habitat.
The cell wall chemistry of Bangia atropurpurea (Bangiales, Rhodophyta) and Bostrychia moritziana (Ceramiales, Rhodophyta) from marine and freshwater environments
Authors: Youngs Heather L. , Gretz Michael R. , West John A. , Sommerfeld Milton R. 
Published: December 2005

SUMMARYThe cell wall polysaccharides of two species of red algae, which are adapted to both freshwater and marine environments, were analysed to determine the effect of these widely different environments on their commercially important agarocolloids and to investigate the possible role of the cell wall in environmental adaptation. Cell wall polymers of freshwater isolates of Bangia atropurpurea (Roth) C. Agardh and cultured freshwater and marine Bostrychia moritziana (Sonder ex Kützing) J. Agardh were isolated and the polysaccharides chemically fractionated and characterized. Wall polysaccharides of freshwater B. atropurpurea were similar to those previously reported for marine isolates with repeating disac‐charide units of agarose and porphyran predominant in the hot water extracts. In the insoluble residues, 3‐iinked galactosyl and 4‐linked mannosyl residues were predominant. Bostrychia moritziana wall polysaccharides included agarocolloids with various patterns of methyl ether substitution similar to those previously described for other Ceramiales. Differences in the position of methyl ether substituents were detected in the hot water extracts of the freshwater and marine specimens. Polymers of freshwater ß. moritziana cultures were composed of a complex mixture of repeating disaccharide units including 2′‐O‐methyl agarose, 6‐O‐methyI agarose and 2′‐O‐methyl porphyran. Polymers of marine isolates of ß. moritziana differ in that they contain only trace amounts of 2‐O‐methyl saccharides and increased amounts of 6‐O‐amethyl saccharides. The hot water insoluble residues of both freshwater and marine isolates of ß. moritziana contain a mixture of 3‐linked galactosyl and 4‐linked glucosyl residues. These results indicate that the adaptive response of B. moritziana to changing osmotic and ionic conditions may include changes in cell wall chemistry: notably, the pattern of methyl ether substitution.