bluuebunny/crossref_metadata_2025_split huggingface dataset:
A New GFSv15 With FV3 Dynamical Core Based Climate Model Large Ensemble and Its Application to Understanding Climate Variability, and Predictability
Authors: Zhang Tao , Yang Weiyu , Quan Xiao‐Wei , Zhu Jieshun , Jha Bhaskar , Kumar Arun , Hoerling Martin P. , Barsugli Joseph J. , Wang Wanqiu 
Published: April 2024

AbstractNOAA Climate Prediction Center (CPC) has generated a 100‐member ensemble of atmospheric model simulations from 1979 to present using the Global Forecast System version 15 (GFSv15) with FV3 dynamical core. The intent of this study is to document a development in an infrastructure capability with a focus to demonstrate the quality of these new simulations is on par with the previous GFSv2 Atmospheric Model Intercomparison Project simulations. These simulations are part of CPC's efforts to attribute observed seasonal climate variability to sea surface temperature (SST) forcings and get updated once a month by available observed SST. The performance of these simulations in replicating observed climate variability and trends, together with an assessment of climate predictability and the attribution of some climate events is documented. A particular focus of the analysis is on the US climate trend, Northern Hemisphere winter height variability, US climate response to three strong El Niño events, the analysis of signal to noise ratio, the anomaly correlation for seasonal climate anomalies, and the South Asian flooding of 2022 summer, and thereby samples wide aspects that are important for attributing climate variability. Results indicate that the new model can realistically reproduce observed climate variability, trends, and extreme events, better capturing the US climate response to extreme El Niño events and the 2022 summer South Asian record‐breaking flooding than GFSv2. The new model also shows an improvement in the wintertime simulation fidelity of US surface climate, mainly confined in the Northern and Southeastern US for precipitation and in the east for temperature.
Multiscale CO Budget Estimates Across South America: Quantifying Local Sources and Long Range Transport
Authors: Lichtig Pablo , Gaubert Benjamin , Emmons Louisa K. , Jo Duseong S. , Callaghan Patrick , Ibarra‐Espinosa Sergio , Dawidowski Laura , Brasseur Guy P. , Pfister Gabriele 
Published: April 2024

AbstractSouth America is a large continent situated mostly in the Southern Hemisphere (SH) with complex topography and diverse emissions sources. However, the atmospheric chemistry of this region has been historically understudied. Here, we employ the Multi‐Scale Infrastructure for Chemistry and Aerosols, a novel global circulation model with regional refinement capabilities and full chemistry, to explore the sources and distribution of the carbon monoxide (CO) tropospheric column in South America during 2019, and also to assess the effect that South American primary emissions have over the rest of the world. Most of the CO over South America can be explained either by non‐methane volatile organic compounds (NMVOC) secondary chemical production or by biomass burning emissions, with biomass burning as the main explanation for the variability in CO. Biomass burning in Central Africa is a relevant contributor to CO in all of the continent, including the southern tip. Biogenic emissions play a dual role in CO concentrations: they provide volatile organic compounds that contribute to the secondary CO production, but they also destroy OH, which limits the chemical production and destruction of CO. As a net effect, the lifetime of CO is extended to ∼120 days on average over the Amazon, while still being in the range of 30–60 days in the rest of South America.
Preference of Afternoon Precipitation Over Dry Soil in the North China Plain During Warm Seasons
Authors: Li Sixuan , Guo Jianping , Zhang Xuanze , Tong Bing , Su Tianning , Wei Jing , Li Zhanqing 
Published: April 2024

AbstractThe influence of soil moisture (SM) on atmospheric precipitation has been extensively studied, but few of these studies have considered the role of land‐atmosphere (L‐A) coupling in afternoon precipitation events (APEs) at a sub‐daily timescale. Here, using in‐situ observations and reanalysis data sets, we investigated the effect of the soil moisture anomaly (SMA) on warm seasons' afternoon precipitation in the North China Plain (NCP), identified as a strong L‐A coupling region. APEs were separated from all precipitation events in the NCP during the warm seasons of 2010–2019. It follows from a comparative analysis that an APE is more likely to be initiated on drier soil, which has little dependence on the thresholds used for identifying an APE. However, no affirmative relationship is found between precipitation amount in the first hour of an APE (APE1hour) and the SMA. Further analyses indicate that larger amounts of APE1hour result from higher convective available potential energy (CAPE), higher moist static energy (MSE), or weaker vertical shear of horizontal wind. When considering the joint effects of SMA and atmospheric variables, APEs tend to occur on drier (wetter) soil with lower (higher) lower‐tropospheric stability, CAPE, or MSE. This study highlights the significant roles of L‐A interactions on local atmospheric precipitation, especially the joint roles of SM and atmospheric variables on precipitation.
Contributions of Jupiter's Deep‐Reaching Surface Winds to Magnetic Field Structure and Secular Variation
Authors: Wicht J. , Christensen U. R. 
Published: April 2024

AbstractNASA's Juno mission delivered gravity data of exceptional quality. They indicate that the zonal winds, which rule the dynamics of Jupiter's cloud deck, must slow down significantly beyond a depth of about 3,000 km. Since the underlying inversion is highly non‐unique additional constraints on the flow properties at depth are required. These could potentially be provided by the magnetic field and its Secular Variation (SV) over time. However, the role of these zonal winds in Jupiter's magnetic field dynamics is little understood. Here we use numerical simulations to explore the impact of the zonal winds on the dynamo field produced at depth. We find that the main effect is an attenuation of the non‐axisymmetric field, which can be quantified by a modified magnetic Reynolds number Rm that combines flow amplitude and electrical conductivity profile. Values below Rm = 3 are required to retain a pronounced non‐axisymmetric feature like the Great Blue Spot (GBS), which seems characteristic for Jupiter's magnetic field. This allows for winds reaching as deep as 3,400 km. A SV pattern similar to the observation can only be found in some of our models. Its amplitude reflects the degree of cancellation between advection and diffusion rather than the zonal wind velocity at any depth. It is therefore not straightforward to make inferences on the deep structure of cloud‐level winds based on Jupiter's SV.
Convection‐Permitting Climate Models Can Support Observations to Generate Rainfall Return Levels
Authors: Poschlod B. , Koh J. 
Published: April 2024

AbstractInformation about the frequency and intensity of extreme precipitation is generally derived from fitting extreme value models using point‐observations, but the regionalization of these models is challenging. Here we propose using high‐resolution convection‐permitting climate model output as covariates for the estimation of observation‐based spatial rainfall return levels. We apply the Weather and Forecasting Research (WRF) model at a 1.5 km resolution driven by ERA5 reanalysis data over southern Germany, where 1,132 rain gauges provide observations of daily rainfall. For this complex topography, we build three different smooth spatial Generalized Extreme Value (GEV) models: (a) a reference model using latitude, longitude and elevation as covariates; (b) a model adding mean annual precipitation from the WRF; (c) a model adding extreme value statistical model estimates using WRF output. We show that the additional information provided by the WRF model can improve the representation of 10‐year and 100‐year return levels of daily rainfall by lowering the percentage bias, mean absolute error, and root‐mean‐square error. Furthermore, we conduct an extensive cross‐validation, where only 5%, 10%, 20%, 50%, 80%, 90%, and 95% of all rain gauges are considered when building spatial GEV models. Again, the additional information provided by the WRF model can improve results here. This cross‐validation study also highlights the robustness of our approach, showing great potential for use in data‐scarce regions.
Dune Development Dominates Flow Resistance Increase in a Large Dammed River
Authors: Hu Yong , Li Dongfeng , Deng Jinyun , Yue Yao , Zhou Junxiong , Yang Chunrui , Zheng Ninghui , Li Yitian 
Published: April 2024

AbstractDunes are important for bedload transport in almost all large river systems and exert an important control flow resistance. Investigating dunes is fundamental for simulating discharge, sediment transport, and flood routing. However, the spatiotemporal dynamics of dunes and flow resistance remain poorly understood in large alluvial river systems mainly due to the lack of high‐resolution data. Here we analyzed in‐field observed data on annual profiles of 450 cross‐sections, river bathymetry, discharge, water levels, and sediment in the Middle Yangtze River, and found that dunes developed and flow resistance increased (+10%) in the post‐Three Gorges Dam period. We ascertain that the development of dunes plays the dominant role in augmenting flow resistance, as evidenced by roughness height change (+29%) using a modified Van Rijn method. Ultimately, dune development was incorporated into a hydrogeomorphic numerical model of the Yangtze River to improve flow resistance quantification, and thus, the water level simulation. Our findings highlight the potential increase in flow resistance in response to upstream damming in large rivers and have important implications for flood management and riverine ecology.
Visceral-to-peripheral adiposity ratio: a critical determinant of sex and ethnic differences in cardiovascular risks among Asian Indians and African Creoles in Mauritius
Authors: Ramessur Vinaysing , Hunma Sadhna , Joonas Noorjehan , Ramessur Bibi Nasreen , Schutz Yves , Montani Jean-Pierre , Dulloo Abdul G. 
Published: April 2024

Abstract
Background/Aims
Coronary heart disease morbidity and mortality are higher in people of South Asian origin than in those of African origin. We investigated whether as young adults without diabetes, people in Mauritius of South Asian descent (Indians) would show a more adverse cardiovascular risk profile that those of predominantly African descent (Creoles), and whether this could be explained by ethnic differences in visceral adiposity or other fat distribution patterns.

Methods
The study was conducted in 189 young non-physically active adults, with the following measurements conducted after an overnight fast: anthropometry (weight, height, waist circumference), whole-body and regional body composition by dual-energy x-ray absorptiometry, blood pressure, and blood assays for glycemic (glucose and HbA1c) and lipid profile (triglycerides and cholesterols).

Results
The results indicate higher serum triglycerides and lower HDL cholesterol in men than in women, and in Indians than in Creoles (p < 0.001). No significant differences due to sex or ethnicity are observed in body mass index and waist circumference, but indices of visceral adiposity (visceral/android, visceral/subcutaneous) and visceral-to-peripheral adiposity ratio (visceral/gynoid, visceral/limb) were significantly higher in men than in women, and in Indians than in Creoles. The significant effects of sex and ethnicity on blood lipid profile were either completely abolished or reduced to a greater extent after adjusting for the ratio of visceral-to-peripheral adiposity than for visceral adiposity per se.

Conclusions
In young adults in Mauritius, Indians show a more adverse pattern of body fat distribution and blood lipid risk profile than Creoles. Differences in their fat distribution patterns, however, only partially explain their differential atherogenic lipid risk profile, amid a greater impact of visceral-to-peripheral adiposity ratio than that of visceral adiposity per se on sex and ethnic differences in cardiovascular risks; the former possibly reflecting the ratio of hazardous (visceral) adiposity and protective (peripheral) superficial subcutaneous adiposity.
The effects of urban green space and road proximity to indoor traffic-related PM2.5, NO2, and BC exposure in inner-city schools
Authors: Matthaios V. N. , Holland I. , Kang C. M. , Hart J. E. , Hauptman M. , Wolfson J. M. , Gaffin J. M. , Phipatanakul W. , Gold D. R. , Koutrakis P. 
Published: April 2024

Abstract
Background
Since there are known adverse health impacts of traffic-related air pollution, while at the same time there are potential health benefits from greenness, it is important to examine more closely the impacts of these factors on indoor air quality in urban schools.

Objective
This study investigates the association of road proximity and urban greenness to indoor traffic-related fine particulate matter (PM2.5), nitrogen dioxide (NO2), and black carbon (BC) in inner-city schools.

Methods
PM2.5, NO2, and BC were measured indoors at 74 schools and outdoors at a central urban over a 10-year period. Seasonal urban greenness was estimated using the Normalized Difference Vegetation Index (NDVI) with 270 and 1230 m buffers. The associations between indoor traffic-related air pollution and road proximity and greenness were investigated with mixed-effects models.

Results
The analysis showed linear decays of indoor traffic-related PM2.5, NO2, and BC by 60%, 35%, and 22%, respectively for schools located at a greater distance from major roads. The results further showed that surrounding school greenness at 270 m buffer was significantly associated (p < 0.05) with lower indoor traffic-related PM2.5: −0.068 (95% CI: −0.124, −0.013), NO2: −0.139 (95% CI: −0.185, −0.092), and BC: −0.060 (95% CI: −0.115, −0.005). These associations were stronger for surrounding greenness at a greater distance from the schools (buffer 1230 m) PM2.5: −0.101 (95% CI: −0.156, −0.046) NO2: −0.122 (95% CI: −0.169, −0.075) BC: −0.080 (95% CI: −0.136, −0.026). These inverse associations were stronger after fully adjusting for regional pollution and meteorological conditions.

Impact statement
More than 90% of children under the age of 15 worldwide are exposed to elevated air pollution levels exceeding the WHO’s guidelines. The study investigates the impact that urban infrastructure and greenness, in particular green areas and road proximity, have on indoor exposures to traffic-related PM2.5, NO2, and BC in inner-city schools. By examining a 10-year period the study provides insights for air quality management, into how road proximity and greenness at different buffers from the school locations can affect indoor exposure.
Biventricular function in preterm infants with patent ductus arteriosus ligation: A three-dimensional echocardiographic study
Authors: Toyoshima Katsuaki , Aoki Hirosato , Noguchi Takahiro , Saito Naka , Shimizu Tatsuto , Kemmotsu Takahiro , Shimokaze Tomoyuki , Saito Tomoko , Shibasaki Jun , Kawataki Motoyoshi , Asou Toshihide , Tachibana Tsuyoshi , Masutani Satoshi 
Published: April 2024

Abstract
Background
The detailed hemodynamics after patent ductus arteriosus (PDA) ligation in preterm infants remain unknown. We aimed to clarify the effect of surgical ligation on left ventricular (LV) and right ventricular (RV) volume and function.

Methods
Echocardiography was performed in 41 preterm infants (median gestational age: 25 weeks) before and after PDA ligation. Global longitudinal strain was determined using three-dimensional speckle-tracking echocardiography. These values were compared with those in 36 preterm infants without PDA (non-PDA).

Results
Preoperatively, the PDA group had greater end-diastolic volume (EDV) and cardiac output (CO) in both ventricles, a higher LV ejection fraction (LVEF) (53% vs 44%) and LV global longitudinal strain, and a lower RVEF (47% vs 52%) than the non-PDA group. At 4–8 h postoperatively, the two groups had a similar LVEDV and RVEDV. However, the PDA group had a lower EF and CO in both ventricles than the non-PDA group. At 24–48 h postoperatively, the RVEF was increased, but the LVEF remained decreased, and LVCO was increased.

Conclusions
PDA induces biventricular loading and functional abnormalities in preterm infants, and they dramatically change after surgery. Three-dimensional echocardiography may be beneficial to understand the status of both ventricles.

Impact

Preterm infants are at high risk of hemodynamic compromise following a sudden change in loading conditions after PDA ligation.

Three-dimensional echocardiography enables quantitative and serial evaluation of ventricular function and volume in preterm infants with PDA.

PDA induces biventricular loading and functional abnormalities in preterm infants, and they dramatically change after surgery.
Value of preclinical systematic reviews and meta-analyses in pediatric research
Authors: Romantsik Olga , Bank Matthias , Menon Julia M. L. , Malhotra Atul , Bruschettini Matteo 
Published: April 2024

Abstract
Similar to systematic reviews (SRs) in clinical fields, preclinical SRs address a specific research area, furnishing information on current knowledge, possible gaps, and potential methodological flaws of study design, conduct, and report. One of the main goals of preclinical SRs is to identify aspiring treatment strategies and evaluate if currently available data is solid enough to translate to clinical trials or highlight the gaps, thus justifying the need for new studies. It is imperative to rigorously follow the methodological standards that are widely available. These include registration of the protocol and adherence to guidelines for assessing the risk of bias, study quality, and certainty of evidence. A special consideration should be made for pediatric SRs, clinical and preclinical, due to the unique characteristics of this age group. These include rationale for intervention and comparison of primary and secondary outcomes. Outcomes measured should acknowledge age-related physiological changes and maturational processes of different organ systems. It is crucial to choose the age of the animals appropriately and its possible correspondence for specific pediatric age groups. The findings of well-conducted SRs of preclinical studies have the potential to provide a reliable evidence synthesis to guide the design of future preclinical and clinical studies.

Impact

This narrative review highlights the importance of rigorous design, conduct and reporting of preclinical primary studies and systematic reviews.

A special consideration should be made for pediatric systematic reviews of preclinical studies, due to the unique characteristics of this age group.
Predictable changes in the accuracy of human papillomavirus tests after vaccination: review with implications for performance monitoring in cervical screening
Authors: Rebolj Matejka , Brentnall Adam R. , Cuschieri Kate 
Published: April 2024

AbstractVaccination against human papillomavirus (HPV) is changing the performance of cytology as a cervical screening test, but its effect on HPV testing is unclear. We review the effect of HPV16/18 vaccination on the epidemiology and the detection of HPV infections and high-grade cervical lesions (CIN2+) to evaluate the likely direction of changes in HPV test accuracy. The reduction in HPV16/18 infections and cross-protection against certain non-16/18 high-risk genotypes, most notably 31, 33, and/or 45, will likely increase the test’s specificity but decrease its positive predictive value (PPV) for CIN2+. Post-vaccination viral unmasking of non-16/18 genotypes due to fewer HPV16 co-infections might reduce the specificity and the PPV for CIN2+. Post-vaccination clinical unmasking exposing a higher frequency of CIN2+ related to non-16/18 high-risk genotypes is likely to increase the specificity and the PPV of HPV tests. The effect of HPV16/18 vaccination on HPV test sensitivity is difficult to predict based on these changes alone. Programmes relying on HPV detection for primary screening should monitor the frequency of false-positive and false-negative tests in vaccinated (younger) vs. unvaccinated (older) cohorts, to assess the outcomes and performance of their service.
Nose-to-brain selective drug delivery to glioma via ferritin-based nanovectors reduces tumor growth and improves survival rate
Authors: Marrocco Francesco , Falvo Elisabetta , Mosca Luciana , Tisci Giada , Arcovito Alessandro , Reccagni Alice , Limatola Cristina , Bernardini Roberta , Ceci Pierpaolo , D’Alessandro Giuseppina , Colotti Gianni 
Published: April 2024

AbstractGliomas are among the most fatal tumors, and the available therapeutic options are very limited. Additionally, the blood-brain barrier (BBB) prevents most drugs from entering the brain. We designed and produced a ferritin-based stimuli-sensitive nanocarrier with high biocompatibility and water solubility. It can incorporate high amounts of the potent topoisomerase 1 inhibitor Genz-644282. Here, we show that this nanocarrier, named The-0504, can cross the BBB and specifically deliver the payload to gliomas that express high amounts of the ferritin/transferrin receptor TfR1 (CD71). Intranasal or intravenous administration of The-0504 both reduce tumor growth and improve the survival rate of glioma-bearing mice. However, nose-to-brain administration is a simpler and less invasive route that may spare most of the healthy tissues compared to intravenous injections. For this reason, the data reported here could pave the way towards a new, safe, and direct ferritin-based drug delivery method for brain diseases, especially brain tumors.
Inhibition of ACSS2-mediated histone crotonylation alleviates kidney fibrosis via IL-1β-dependent macrophage activation and tubular cell senescence
Authors: Li Lingzhi , Xiang Ting , Guo Jingjing , Guo Fan , Wu Yiting , Feng Han , Liu Jing , Tao Sibei , Fu Ping , Ma Liang 
Published: April 2024

AbstractHistone lysine crotonylation (Kcr), as a posttranslational modification, is widespread as acetylation (Kac); however, its roles are largely unknown in kidney fibrosis. In this study, we report that histone Kcr of tubular epithelial cells is abnormally elevated in fibrotic kidneys. By screening these crotonylated/acetylated factors, a crotonyl-CoA-producing enzyme ACSS2 (acyl-CoA synthetase short chain family member 2) is found to remarkably increase histone 3 lysine 9 crotonylation (H3K9cr) level without influencing H3K9ac in kidneys and tubular epithelial cells. The integrated analysis of ChIP-seq and RNA-seq of fibrotic kidneys reveal that the hub proinflammatory cytokine IL-1β, which is regulated by H3K9cr, play crucial roles in fibrogenesis. Furthermore, genetic and pharmacologic inhibition of ACSS2 both suppress H3K9cr-mediated IL-1β expression, which thereby alleviate IL-1β-dependent macrophage activation and tubular cell senescence to delay renal fibrosis. Collectively, our findings uncover that H3K9cr exerts a critical, previously unrecognized role in kidney fibrosis, where ACSS2 represents an attractive drug target to slow fibrotic kidney disease progression.