bluuebunny/crossref_metadata_2025_split huggingface dataset:
Protecting peer review: Correspondence chronology and ethical analysis regarding Logothetis vs. Shmuel and Leopold
Authors: Fox Peter T. , Bullmore Ed , Bandettini Peter A. , Lancaster Jack L. 
Published: December 2008

AbstractEditors of scientific journals are ethically bound to provide a fair and impartial peer‐review process and to protect the rights of contributing authors to publish research results. If, however, a dispute arises among investigators regarding data ownership and the right to publish, the ethical responsibilities of journal editors become more complex. The editors of Human Brain Mapping recently had the unusual experience of learning of an ongoing dispute regarding data‐access rights pertaining to a manuscript already accepted for publication. Herein the editors describe the nature of the dispute, the steps taken to explore and resolve the conflict, and discuss the ethical principles that govern such circumstances. Drawing on this experience and with the goal of avoiding future controversies, the editors have formulated a Data Rights Policy and a Data Rights Procedure for Human Brain Mapping. Human Brain Mapping adopts this policy effective immediately and respectfully suggests that other journals consider adopting this or similar policies. Hum Brain Mapp, 2009. © 2008 Wiley‐Liss, Inc.
The neuronal substrates of human olfactory based kin recognition
Authors: Lundström Johan N. , Boyle Julie A. , Zatorre Robert J. , Jones‐Gotman Marilyn 
Published: December 2008

AbstractKin recognition, an evolutionary phenomenon ubiquitous among phyla, is thought to promote an individual's genes by facilitating nepotism and avoidance of inbreeding. Whereas isolating and studying kin recognition mechanisms in humans using auditory and visual stimuli is problematic because of the high degree of conscious recognition of the individual involved, kin recognition based on body odors is done predominantly without conscious recognition. Using this, we mapped the neural substrates of human kin recognition by acquiring measures of regional cerebral blood flow from women smelling the body odors of either their sister or their same‐sex friend. The initial behavioral experiment demonstrated that accurate identification of kin is performed with a low conscious recognition. The subsequent neuroimaging experiment demonstrated that olfactory based kin recognition in women recruited the frontal‐temporal junction, the insula, and the dorsomedial prefrontal cortex; the latter area is implicated in the coding of self‐referent processing and kin recognition. We further show that the neuronal response is seemingly independent of conscious identification of the individual source, demonstrating that humans have an odor based kin detection system akin to what has been shown for other mammals. Hum Brain Mapp 2009. © 2008 Wiley‐Liss, Inc.
Sorbitan monooleate and poly(L‐lactide‐co‐ε‐caprolactone) electrospun nanofibers for endothelial cell interactions
Authors: Li Xiaoqiang , Su Yan , He Chuanglong , Wang Hongsheng , Fong Hao , Mo Xiumei 
Published: December 2008

AbstractThe aim of this study was to investigate electrospinning of emulsions to prepare core‐shell type of nanofibers for being an innovative type of cell‐growth scaffolds with potentially controllable drug‐releasing capabilities. The hypothesis was that the poly(L‐lactide‐co‐ε‐caprolactone) [P(LLA‐CL), shell] nanofibrous mats containing sorbitan monooleate (Span‐80, core) could be appropriate scaffolds for growing pig iliac endothelium cells (PIECs). To test the hypothesis, the electrospinning of emulsions made of P(LLA‐CL), chloroform, Span‐80, and distilled water to prepare P(LLA‐CL)/Span‐80 nanofibers was systematically investigated. The effects of water content and P(LLA‐CL) concentration in the emulsions on the morphologies of the nanofibers were studied. The morphologies, mechanical properties, and surface hydrophilicity of the nanofibrous mats were examined. The performance for being scaffolds was investigated by examination of the viability (anchorage and proliferation) and morphology of PIECs on the nanofibrous mats. There were no statistically significant differences in endothelial cell growth on the core‐shell nanofibrous mats compared to the polymeric nanofibrous mats, and the P(LLA‐CL)/Span‐80 nanofiber mats could be used as an innovative type of scaffolds with potentially controllable drug‐releasing capabilities. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res 2009
Mouse adenovirus type 1 and human adenovirus type 5 differ in endothelial cell tropism and liver targeting
Authors: Lenaerts Liesbeth , McVey John H. , Baker Andrew H. , Denby Laura , Nicklin Stuart , Verbeken Erik , Naesens Lieve 
Published: December 2008

AbstractBackgroundFor adenovirus vectors derived from human serotype 5 (Ad5), the efficiency and safety after intravascular delivery is hindered by their sequestration in nontarget tissues, predominantly the liver. The latter is largely dictated by adenovirus binding to blood coagulation zymogens. In addition, several target cells, such as endothelial and smooth muscle cells, are difficult to transduce by Ad5 due to the low expression of the primary coxsackie‐adenovirus receptor (CAR). Therefore, alternative adenovirus serotypes are being explored.MethodsIn the present study, we assessed the tropism of mouse adenovirus type 1 (MAV‐1), a nonhuman adenovirus for which cellular attachment is CAR‐independent.ResultsThe typical replication of MAV‐1 in endothelial cells as observed in vivo was not reflected in elevated attachment to primary and continuous endothelial cells in cell culture. Remarkably, MAV‐1 displayed a higher affinity for primary human smooth muscle cells than recombinant Ad5 (rAd5). Attachment of MAV‐1 to human and mouse cells of hepatocyte origin was not altered by physiological concentrations of human coagulation factor XI (FXI) or the vitamin K‐dependent FIX, FX and FVII. By contrast, attachment of Ad5‐derived vectors was enhanced at least eight‐fold by FX. Using surface plasmon resonance, MAV‐1 was shown to directly associate with human FX and murine FX and FIX but, opposite to rAd5, this interaction did not lead to enhanced cellular attachment. In intravenously injected severe combined immunodeficiency mice, distribution of MAV‐1 to the liver was markedly lower than that observed with rAd5.ConclusionsOur data on the tropism of MAV‐1 suggest that this virus may find utility in the field of gene therapy. Copyright © 2008 John Wiley & Sons, Ltd.
To link or not to link: a test of the case linkage principles using serial car theft data
Authors: Tonkin Matthew , Grant Tim , Bond John W. 
Published: December 2008

AbstractThe purpose of the present study is to test the case linkage principles of behavioural consistency and behavioural distinctiveness using serial vehicle theft data. Data from 386 solved vehicle thefts committed by 193 offenders were analysed using Jaccard's, regression and Receiver Operating Characteristic analyses to determine whether objectively observable aspects of crime scene behaviour could be used to distinguish crimes committed by the same offender from those committed by different offenders. The findings indicate that spatial behaviour, specifically the distance between theft locations and between dump locations, is a highly consistent and distinctive aspect of vehicle theft behaviour; thus, intercrime and interdump distance represent the most useful aspects of vehicle theft for the purpose of case linkage analysis. The findings have theoretical and practical implications for understanding of criminal behaviour and for the development of decision‐support tools to assist police investigation and apprehension of serial vehicle theft offenders. Copyright © 2008 John Wiley & Sons, Ltd.
A cognitive load approach to lie detection
Authors: Vrij Aldert , Fisher Ronald , Mann Samantha , Leal Sharon 
Published: December 2008

AbstractWe present two lie detection approaches based on cognitive theory. The first approach, ‘measuring cognitive load’, assumes that the mere act of lying generates observable signs of cognitive load. This is the traditional cognitive lie detection approach formulated by Zuckerman, DePaulo, & Rosenthal (1981). The second approach, ‘imposing cognitive load’, was developed by us (Vrij, Fisher, Mann, & Leal, 2006) and goes one step further. Here, the lie detector attempts to actively increase the differences between lying and truth telling by introducing mentally taxing interventions. We assume that people require more cognitive resources when they lie than when they tell the truth to produce their statements, and therefore will have fewer cognitive resources left over to address these mentally taxing interventions when they lie than when they tell the truth. This should result in more pronounced differences between lying and truth telling in terms of displaying stronger signs of cognitive load. We provide empirical support for this approach: Observers can discriminate better between lying and truth telling when interviewers actively impose mentally taxing interventions. Copyright © 2008 John Wiley & Sons, Ltd.
Interviewing a psychopathic suspect
Authors: Quayle Jeremy 
Published: December 2008

AbstractPsychopathy is a personality disorder characterised by affective, interpersonal, antisocial, and lifestyle elements. Studies of the association between psychopathy (e.g. as operationalised in the Psychopathy Checklist—Revised) and criminal behaviour suggest that police interviewers and interview advisors would benefit from an understanding of how psychopathic suspects are likely to behave during investigative interviews. Approaches to the identification of psychopathic characteristics in suspects are considered with reference to the P‐Scan screening tool and possible indicators of psychopathic characteristics in serious offences. Psychopathic characteristics that are likely to impact upon interview behaviour are outlined in order to suggest how the effects of these may be anticipated, and how strategies may be employed to maximise an interviewee's productive participation in the interview and to minimise the interviewee's tendency to disrupt, distort, or control the interview process. The manner in which psychopathic individuals attempt to deceive others and how a psychopathic suspect's lies might be identified are discussed. Copyright © 2008 John Wiley & Sons, Ltd.
Performance comparison of some dynamical and empirical downscaling methods for South Africa from a seasonal climate modelling perspective
Authors: Landman Willem A. , Kgatuke Mary‐Jane , Mbedzi Maluta , Beraki Asmerom , Bartman Anna , Piesanie Annelise du 
Published: December 2008

AbstractThe ability of advanced state‐of‐the‐art methods of downscaling large‐scale climate predictions to regional and local scale as seasonal rainfall forecasting tools for South Africa is assessed. Various downscaling techniques and raw general circulation model (GCM) output are compared to one another over 10 December‐January‐February (DJF) seasons from 1991/1992 to 2000/2001 and also to a baseline prediction technique that uses only global sea‐surface temperature (SST) anomalies as predictors. The various downscaling techniques described in this study include both an empirical technique called model output statistics (MOS) and a dynamical technique where a finer resolution regional climate model (RCM) is nested into the large‐scale fields of a coarser GCM. The study addresses the performance of a number of simulation systems (no forecast lead‐time) of varying complexity. These systems' performance is tested for both homogeneous regions and for 963 stations over South Africa, and compared with each other over the 10‐year test period. For the most part, the simulations method outscores the baseline method that uses SST anomalies to simulate rainfall, therefore providing evidence that current approaches in seasonal forecasting are outscoring earlier ones. Current operational forecasting approaches involve the use of GCMs, which are considered to be the main tool whereby seasonal forecasting efforts will improve in the future. Advantages in statistically post‐processing output from GCMs as well as output from RCMs are demonstrated. Evidence is provided that skill should further improve with an increased number of ensemble members. The demonstrated importance of statistical models in operation capacities is a major contribution to the science of seasonal forecasting. Although RCMs are preferable due to physical consistency, statistical models are still providing similar or even better skill and should still be applied. Copyright © 2008 Royal Meteorological Society
Bioactive peptide production by hydrolysis of porcine blood proteins in a continuous enzymatic membrane reactor
Authors: Wei Jen‐Ting , Chiang Been‐Huang 
Published: December 2008

AbstractBACKGROUND: During slaughter a hog produces approximately 3 L of blood. However, only a small proportion of porcine blood is currently used in food, feed or fertiliser, most of it being treated as waste and discarded. In this study the possibility of hydrolysing porcine blood proteins by enzyme in a membrane reactor for the production of bioactive peptides was investigated. Red blood corpuscles, blood plasma and defibrinated blood plasma were hydrolysed by various proteases, and the hydrolysates were evaluated for bioactive properties.RESULTS: The hydrolysate produced by hydrolysing red blood corpuscles with a mixture of trypsin, chymotrypsin and thermolysin had the highest angiotensin I‐converting enzyme (ACE)‐inhibitory activity (IC50 = 0.58 mg mL−1) and scavenging effect on α,α‐diphenyl‐β‐picrylhydrazyl (DPPH) (65%) after 6 and 10 h of hydrolysis respectively. When the hydrolysis was carried out in an enzymatic membrane reactor with an enzyme/substrate ratio of 1:5 and a residence time of 100 min, the process reached steady state in 2 h. The ACE‐inhibitory activity of the product during the steady state process was 86% and its scavenging effect on DPPH was 54%. The membrane process also decolourised the enzyme‐hydrolysed product, thus improving the appearance of the product.CONCLUSION: This study demonstrated that hydrolysates of porcine blood possess antihypertensive and antioxidant activities. Using red blood corpuscles as the substrate, the hydrolysis could be carried out in a membrane reactor with a mixture of proteases to produce bioactive peptides continuously. Therefore processing of porcine blood in an enzymatic membrane reactor is a potential method for producing a health‐promoting product. Copyright © 2008 Society of Chemical Industry
Highly selective artificial gel antibodies for detection and quantification of biomarkers in clinical samples. II. Albumin in body fluids of patients with neurological disorders
Authors: Ghasemzadeh Nasim , Nyberg Fred , Hjertén Stellan 
Published: December 2008

AbstractWe have previously used the molecular‐imprinting method for the synthesis of artificial gel antibodies, highly selective for various proteins. In the present work, we have synthesized artificial gel antibodies against human albumin with the aim to develop a simple and rapid procedure to measure the concentration of this protein in samples of clinical interest. The procedure, based on the design of a standard curve (see the preceding paper), was applied on a quantitative analysis of albumin in human plasma and cerebrospinal fluid (CSF). We found that our technique permitted detection of albumin in these body fluids with high precision and that the concentration of this protein was significantly enhanced in CSF from patients with amyotrophic lateral sclerosis (ALS), compared to control samples. This finding is in agreement with results from earlier studies, which confirms the validity of our analysis technique and suggests that the barrier permeability may be affected in ALS, perhaps also for other proteins. No enhancement in plasma levels of albumin was seen in patients with ALS, but rather a decrease. The results further indicate that our approach might also apply well to other biomarkers for the actual neurological disease and other disorders.
Complete assignments of 1H and 13C NMR spectroscopic data for three new stigmastane glycosides from Vernonia cumingiana
Authors: Suo Maorong , Yang Junshan 
Published: December 2008

AbstractThree new steroidal saponins, Vernoniosides S1 (1), Vernoniosides S2 (2) and Vernoniosides S3 (3) were isolated from the stem of Vernonia cumingian. Their chemical structures were elucidated on the basis of MS, NMR spectroscopic and chemical analysis. Complete assignment of 1H and 13C NMR spectroscopic data were achieved by 1D and 2D NMR experiments (HMQC, HMBC, ROESY). Copyright © 2008 John Wiley & Sons, Ltd.
Bifurcation modeling in geomaterials: From the second‐order work criterion to spectral analyses
Authors: Prunier F. , Laouafa F. , Lignon S. , Darve F. 
Published: December 2008

AbstractThe present paper investigates bifurcation analysis based on the second‐order work criterion, in the framework of rate‐independent constitutive models and rate‐independent boundary‐value problems. The approach applies mainly to nonassociated materials such as soils, rocks, and concretes. The bifurcation analysis usually performed at the material point level is extended to quasi‐static boundary‐value problems, by considering the stiffness matrix arising from finite element discretization. Lyapunov's definition of stability (Annales de la faculté des sciences de Toulouse 1907; 9:203–274), as well as definitions of bifurcation criteria (Rice's localization criterion (Theoretical and Applied Mechanics. Fourteenth IUTAM Congress, Amsterdam, 1976; 207–220) and the plasticity limit criterion are revived in order to clarify the application field of the second‐order work criterion and to contrast these criteria. The first part of this paper analyses the second‐order work criterion at the material point level. The bifurcation domain is presented in the 3D stress space as well as 3D cones of unstable loading directions for an incrementally nonlinear constitutive model. The relevance of this criterion, when the nonlinear constitutive model is expressed in the classical form (dσ = Mdε) or in the dual form (dε = Ndσ), is discussed. In the second part, the analysis is extended to the boundary‐value problems in quasi‐static conditions. Nonlinear finite element computations are performed and the global tangent stiffness matrix is analyzed. For several examples, the eigenvector associated with the first vanishing eigenvalue of the symmetrical part of the stiffness matrix gives an accurate estimation of the failure mode in the homogeneous and nonhomogeneous boundary‐value problem. Copyright © 2008 John Wiley & Sons, Ltd.
Antiparasitic, nematicidal and antifouling constituents from Juniperus berries
Authors: Samoylenko Volodymyr , Dunbar D. Chuck , Gafur Md. Abdul , Khan Shabana I. , Ross Samir A. , Mossa Jaber S. , El‐Feraly Farouk S. , Tekwani Babu L. , Bosselaers Jan , Muhammad Ilias 
Published: December 2008

AbstractA bioassay‐guided fractionation of Juniperus procera berries yielded antiparasitic, nematicidal and antifouling constituents, including a wide range of known abietane, pimarane and labdane diterpenes. Among these, abieta‐7,13‐diene (1) demonstrated in vitro antimalarial activity against Plasmodium falciparum D6 and W2 strains (IC50 = 1.9 and 2.0 µg/mL, respectively), while totarol (6), ferruginol (7) and 7β‐hydroxyabieta‐8,13‐diene‐11,12‐dione (8) inhibited Leishmania donovani promastigotes with IC50 values of 3.5–4.6 µg/mL. In addition, totarol demonstrated nematicidal and antifouling activities against Caenorhabditis elegans and Artemia salina at a concentration of 80 µg/mL and 1 µg/mL, respectively. The resinous exudate of J. virginiana afforded known antibacterial E‐communic acid (4) and 4‐epi‐abietic acid (5), while the volatile oil from its trunk wood revealed large quantities of cedrol (9). Using GC/MS, the two known abietanes totarol (6) and ferruginol (7) were identified from the berries of J. procera, J. excelsa and J. phoenicea. Copyright © 2008 John Wiley & Sons, Ltd.
Improving peptide identification using an empirical peptide retention time database
Authors: Sun Wei , Zhang Ling , Yang Ruifeng , Shao Chen , Zhang Zhengguo , Gao Youhe 
Published: December 2008

AbstractPeptide retention time (RT) is independent of tandem mass spectrometry (MS/MS) parameters and can be combined with MS/MS information to enhance peptide identification. In this paper, we utilized peptide empirical RT and MS/MS for peptide identification. This new approach resulted in the construction of an Empirical Peptide Retention Time Database (EPRTD) based on peptides showing a false‐positive rate (FPR) ≤1%, detected in several liquid chromatography (LC)/MS/MS analyses. In subsequent experiments, the RT of peptides with FPR >1% was compared with empirical data derived from the EPRTD. If the experimental RT was within a specified time range of the empirical value, the corresponding MS/MS spectra were accepted as positive. Application of the EPRTD approach to simple samples (known protein mixtures) and complex samples (human urinary proteome) revealed that this method could significantly enhance peptide identification without compromising the associated confidence levels. Further analysis indicated that the EPRTD approach could improve low‐abundance peptides and with the expansion of the EPRTD the number of peptide identifications will be increased. This approach is suitable for large‐scale clinical proteomics research, in which tens of LC/MS/MS analyses are run for different samples with similar components. Copyright © 2008 John Wiley & Sons, Ltd.
Simultaneous determination of 8‐oxo‐2′‐deoxyguanosine and 8‐oxo‐2′‐deoxyadenosine in DNA using online column‐switching liquid chromatography/tandem mass spectrometry
Authors: Singh Rajinder , Teichert Friederike , Verschoyle Richard D. , Kaur Balvinder , Vives Montserrat , Sharma Ricky A. , Steward William P. , Gescher Andreas J. , Farmer Peter B. 
Published: December 2008

AbstractSensitive and reliable methods are required for the assessment of oxidative DNA damage, which can result from reactive oxygen species that are generated endogenously from cellular metabolism and inflammatory responses, or by exposure to exogenous agents. The development of a liquid chromatography/tandem mass spectrometry (LC/MS/MS) selected reaction monitoring (SRM) method is described, that utilises online column‐switching valve technology for the simultaneous determination of two DNA adduct biomarkers of oxidative stress, 8‐oxo‐7,8‐dihydro‐2′‐deoxyguanosine (8‐oxodG) and 8‐oxo‐7,8‐dihydro‐2′‐deoxyadenosine (8‐oxodA). To allow for the accurate quantitation of both adducts the corresponding [15N5]‐labelled stable isotope internal standards were synthesised and added prior to enzymatic hydrolysis of the DNA samples to 2′‐deoxynucleosides. The method required between 10 and 40 µg of hydrolysed DNA on‐column for the analysis and the limit of detection for both 8‐oxodG and 8‐oxodA was 5 fmol. The analysis of calf thymus DNA treated in vitro with methylene blue (ranging from 5 to 200 µM) plus light showed a dose‐dependent increase in the levels of both 8‐oxodG and 8‐oxodA. The level of 8‐oxodG was on average 29.4‐fold higher than that of 8‐oxodA and an excellent linear correlation (r = 0.999) was observed between the two adducts. The influence of different DNA extraction procedures for 8‐oxodG and 8‐oxodA levels was assessed in DNA extracted from rat livers following dosing with carbon tetrachloride. The levels of 8‐oxodG and 8‐oxodA were on average 2.9 (p = 0.018) and 1.4 (p = 0.018) times higher, respectively, in DNA samples extracted using an anion‐exchange column procedure than in samples extracted using a chaotropic procedure, implying artefactual generation of the two adducts. In conclusion, the online column‐switching LC/MS/MS SRM method provides the advantages of increased sample throughput with reduced matrix effects and concomitant ionisation suppression, making the method ideally suited when used in conjunction with chaotropic DNA extraction for the determination of oxidative DNA damage. Copyright © 2008 John Wiley & Sons, Ltd.