bluuebunny/crossref_metadata_2025_split huggingface dataset:
Shwachman syndrome as mutator phenotype responsible for myeloid dysplasia/neoplasia through karyotype instability and chromosomes 7 and 20 anomalies
Authors: Maserati Emanuela , Minelli Antonella , Pressato Barbara , Valli Roberto , Crescenzi Barbara , Stefanelli Maurizio , Menna Giuseppe , Sainati Laura , Poli Furio , Panarello Claudio , Zecca Marco , Curto Francesco Lo , Mecucci Cristina , Danesino Cesare , Pasquali Francesco 
Published: December 2005

AbstractAn investigation of 14 patients with Shwachman syndrome (SS), using standard and molecular cytogenetic methods and molecular genetic techniques, showed that (1) the i(7)(q10) is not, or not always, an isochromosome but may arise from a more complex mechanism, retaining part of the short arm; (2) the i(7)(q10) has no preferential parental origin; (3) clonal chromosome changes, such as chromosome 7 anomalies and del(20)(q11), may be present in the bone marrow (BM) for a long time without progressing to myelodysplastic syndrome (MDS)/acute myeloid leukemia (AML); (4) the del(20)(q11) involves the minimal region of deletion typical of MDS/AML; (5) the rate of chromosome breaks is not significantly higher than in controls, from which it is concluded that SS should not be considered a breakage syndrome; (6) a specific kind of karyotype instability is present in SS, with chromosome changes possibly found in single cells or small clones, often affecting chromosomes 7 and 20, in the BM. Hence, we have confirmed our previous hypothesis that the SS mutation itself implies a mutator effect that is responsible for MDS/AML through these specific chromosome anomalies. This conclusion supports the practice of including cytogenetic monitoring in the follow‐up of SS patients. © 2005 Wiley‐Liss, Inc.
Multicolor fluorescence in situ hybridization (SKY) in mycosis fungoides and Sézary syndrome: Search for recurrent chromosome abnormalities
Authors: Batista Denise A S. , Vonderheid Eric C. , Hawkins Anita , Morsberger Laura , Long Patricia , Murphy Kathleen M. , Griffin Constance A. 
Published: December 2005

AbstractCutaneous T‐cell lymphoma (CTCL) is a clonally derived lymphoproliferative disorder that preferentially involves the skin. The two major clinical expressions of CTCL, mycosis fungoides (MF) and Sézary syndrome (SS), have poorly understood pathogenesis. Chromosome abnormalities, mostly complex karyotypes, are seen in about 50% of patients with MF/SS, and there have only been a few instances of recurrent rearrangements. We analyzed 19 blood samples from patients with MF/SS with cytogenetics and multicolor FISH (SKY) to better describe the complex karyotypes and search for recurrent abnormalities or breakpoints. Comparison of phytohemagglutinin (PHA)–stimulated cultures versus a combination of interleukin 2 plus interleukin 7 showed similar efficiency in detecting abnormal clones; however, the PHA cultures yielded more analyzable metaphases. Nine of 19 patients (47%) had an abnormal karyotype. The most frequent abnormalities, in 7 of 9 cases, involved chromosome 10; followed by chromosome 6, in 6 of 9 cases; chromosomes 3, 7, 9, 17, and 19, in 5 of 9 cases; chromosomes 1 and 12, in 4 of 9 cases; and chromosomes 8, 11, and 13, in 3 of 9 cases. Most abnormalities were structural. Recurrent rearrangements included deleted chromosomes 6 and 13, in three cases each, and recurrent breakpoints at 1p32–36, 6q22–25, 17p11.2–13, 10q23–26, and 19p13.3, occurring in three or more cases. One patient had a pseudodicentric translocation between the short arms of chromosomes 8 and 17, confirmed by dual‐color FISH and interpreted as psu dic(17;8)(p11.2;p11.2). Two patients with SS reported in the literature seem to have a similar translocation. If confirmed, a psu dic(17;8) could be the first recurring translocation detected in at least three patients with MF/SS. © 2005 Wiley‐Liss, Inc.
Optimized and parallelized implementation of the electronegativity equalization method and the atom‐bond electronegativity equalization method
Authors: Vařeková R. Svobodová , Koča J. 
Published: December 2005

AbstractThe most common way to calculate charge distribution in a molecule is ab initio quantum mechanics (QM). Some faster alternatives to QM have also been developed, the so‐called “equalization methods” EEM and ABEEM, which are based on DFT. We have implemented and optimized the EEM and ABEEM methods and created the EEM SOLVER and ABEEM SOLVER programs. It has been found that the most time‐consuming part of equalization methods is the reduction of the matrix belonging to the equation system generated by the method. Therefore, for both methods this part was replaced by the parallel algorithm WIRS and implemented within the PVM environment. The parallelized versions of the programs EEM SOLVER and ABEEM SOLVER showed promising results, especially on a single computer with several processors (compact PVM). The implemented programs are available through the Web page http://ncbr.chemi.muni.cz/∼n19n/eem_abeem. © 2005 Wiley Periodicals, Inc. J Comput Chem 27:396–405, 2006
Multibaric–multithermal ensemble molecular dynamics simulations
Authors: Okumura Hisashi , Okamoto Yuko 
Published: December 2005

AbstractWe present new generalized‐ensemble molecular dynamics simulation algorithms, which we refer to as the multibaric–multithermal molecular dynamics. We describe three algorithms based on (1) the Nosé thermostat and the Andersen barostat, (2) the Nosé–Poincaré thermostat and the Andersen barostat, and (3) the Gaussian thermostat and the Andersen barostat. The multibaric–multithermal simulations perform random walks widely both in the potential‐energy space and in the volume space. Therefore, one can calculate isobaric–isothermal ensemble averages in wide ranges of temperature and pressure from only one simulation run. We test the effectiveness of the multibaric–multithermal algorithm by applying it to a Lennard–Jones 12‐6 potential system. © 2005 Wiley Periodicals, Inc. J Comput Chem 27: 379–395, 2006
On the asymptotic behaviour of the discrete spectrum in buckling problems for thin plates
Authors: Dauge Monique , Suri Manil 
Published: December 2005

AbstractWe consider the buckling problem for a family of thin plates with thickness parameterε. This involves finding the least positive multipleλof the load that makes the platebuckle, a value that can be expressed in terms of an eigenvalue problem involving a non‐compact operator. We show that under certain assumptions on the load, we haveλ=𝒪(ε2). This guarantees that provided the plate is thin enough, this minimum value can be numerically approximated without the spectral pollution that is possible due to the presence of the non‐compact operator. We provide numerical computations illustrating some of our theoretical results. Copyright © 2005 John Wiley & Sons, Ltd.
The destabilizing effect of boundary slip on Bénard convection
Authors: Webber Mark 
Published: December 2005

AbstractWe investigate the influence of slip boundary conditions on the onset of Bénard convection in an infinite fluid layer. It is shown that the critical Rayleigh number is a decreasing function of the slip length, and therefore boundary slip is seen to have a destabilizing effect. Chebyshev‐tau and compound matrix formulations for solving the eigenvalue problem are presented. Copyright © 2005 John Wiley & Sons, Ltd.
Weyl transforms associated with the Hankel transform in Clifford analysis
Authors: Zhao Jiman , Li Hongbo 
Published: December 2005

AbstractIn this paper, we define the Hankel–Wigner transform in Clifford analysis and therefore define the corresponding Weyl transform. We present some properties of this kind of Hankel–Wigner transform, and then give the criteria of the boundedness of the Weyl transform and compactness on the Lp space. Copyright © 2005 John Wiley & Sons, Ltd.
Na+‐K+‐ATPase is not involved in the warming‐up phenomenon in generalized myotonia
Authors: Van Beekvelt Mireille C.P. , Drost Gea , Rongen Gerard , Stegeman Dick F. , Van Engelen Baziel G.M. , Zwarts Machiel J. 
Published: December 2005

AbstractThe initial temporary weakness that occurs in autosomal‐recessive generalized myotonia diminishes with repetitive contractions. Physiological understanding of this phenomenon is incomplete. The underlying hypothesis of our study was that the “warming‐up” phenomenon relates to the exercise‐related activation of Na+‐K+‐ATPase. Three patients performed isometric exercise of the brachioradialis muscle on two separate days. Randomly, on one of these days the contraction was preceded by a 30‐min infusion of the Na+‐K+‐ATPase inhibitor ouabain into the brachial artery of the exercising arm (0.4 μg.min–1.dl–1). Force was measured simultaneously with electrical muscle activity using high‐density surface electromyography (HD‐sEMG). A transient rapid decline in force occurred after initiation of exercise, accompanied by electrophysiological changes indicating sarcolemmal conduction block. Ouabain infusion did not affect the recovery from transient paresis or the accompanying electromyographic changes, indicating that the warming‐up phenomenon in generalized myotonia is not mediated by Na+‐K+‐ATPase. Muscle Nerve, 2005
Single‐fiber electromyography in limb and facial muscles in muscle‐specific kinase antibody and acetylcholine receptor antibody myasthenia gravis
Authors: Farrugia Maria Elena , Kennett Robin P. , Newsom‐Davis John , Hilton‐Jones David , Vincent Angela 
Published: December 2005

AbstractWe examined the findings from single‐fiber electromyography in extensor digitorum communis (EDC) and orbicularis oculi (OOc) in 13 myasthenia gravis (MG) patients with muscle‐specific kinase antibodies (MuSK‐MG) and 12 MG patients with acetylcholine receptor antibodies (AChR‐MG) with similar clinical scores. More than 70% of AChR‐MG patients had abnormal jitter in both EDC and OOc, but the majority of MuSK‐MG patients had normal jitter in EDC despite abnormal jitter in OOc. These findings demonstrate clear differences between the neurophysiology of MuSK‐MG and AChR‐MG. Muscle Nerve, 2005
A new reformulation approach for the generalized partial covering problem
Authors: Lee Youngho , Sherali Hanif D. , Kwon Ikhyun , Kim Seongin 
Published: December 2005

AbstractIn this paper, we consider a situation in which a group of facilities must be constructed in order to serve a given set of customers, where the facilities might not be able to guarantee an absolute coverage to the different customers. We examine the problem of maximizing the total service reliability of the system subject to a budgetary constraint. We propose a new reformulation of this problem that facilitates the generation of tight lower and upper bounds. These bounding mechanisms are embedded within the framework of a branch‐and‐bound procedure. Computational results on problem instances ranging in size up to 100 facilities and 200 customers reveal the efficacy of the proposed exact and heuristic approaches. © 2005 Wiley Periodicals, Inc. Naval Research Logistics, 2006
Eigenvalue estimates for preconditioned saddle point matrices
Authors: Axelsson Owe , Neytcheva Maya 
Published: December 2005

AbstractNew accurate eigenvalue bounds for symmetric matrices of saddle point form are derived and applied for both unpreconditioned and preconditioned versions of the matrices. The estimates enable a better understanding of how preconditioners should be chosen. The preconditioners provide efficient iterative solution of the corresponding linear systems with, for some important applications, an optimal order of computational complexity. The methods are applied for Stokes problem and for linear elasticity problems. Copyright © 2005 John Wiley & Sons, Ltd.
A mathematical model of clarifier‐thickener units
Authors: Bürger Raimund , Karlsen Kenneth H. , Towers John D. 
Published: December 2005

AbstractWe review a recent analysis of a clarifier‐thickener model for flocculated suspensions. The resulting governing PDE is a strongly degenerate convection‐diffusion equation with discontinuous flux. A new numerical example illustrates how control actions speed up thickener operation significantly. (© 2005 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Eulerian Model of Diesel Fuel Sprays
Authors: Diviš Marcel , Macek Jan , Kozel Karel 
Published: December 2005

AbstractThe contribution reviews the research activities on modeling the fuel spray formation in combustion chamber of Diesel engines. A fully Eulerian code has been developed for computing the two‐phase flows of drops dispersed in gaseous environment. Both the multi‐component compressible gas and the drops are described using governing equations written in Eulerian coordinates. The basic laws of conservation are balanced on finite volumes with arbitrary movable boundaries. This facilitates the modeling of movable boundary problems (e.g. computations with moving engine piston). The model features full coupling between both phases in mass, momentum, and energy equations. The drop size distribution in sprays is taken into account using the multi‐continua approach. (© 2005 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Momentum and Energy Transfer During Phase Change of Water Under High Hydrostatic Pressure
Authors: Ferstl Peter , Özmutlu Özlem , Hartmann Christoph , Baars Albert , Delgado Antonio 
Published: December 2005

AbstractIn this study, the first visualization of distributed phase change effects and thermodynamical properties under high pressure have been carried out by means of HP‐DPIV and HP‐DPIT (High Pressure Digital Particle Image Velocimetry and Thermography) methods [1]. The main objective of this study was to investigate the thermofluiddynamical behaviour in the high pressure cell during Pressure Induced Thawing of Ice I, Pressure Shift Freezing of Ice I and Pressure Assisted Thawing of Ice III. (© 2005 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Mixing Model Based on Parameterized Scalar Profiles
Authors: Meyer D. W. , Jenny P. 
Published: December 2005

AbstractThe composition fields in turbulent reacting flows are affected by turbulent transport (macromixing), molecular diffusion (micromixing), and chemical reactions. In the joint velocity‐composition probability density function transport equation the highly nonlinear macromixing and chemical reaction terms appear in closed form. This is a considerable advantage over second moment closure methods. Micromixing on the other hand requires modelling and especially for turbulent combustion accurate mixing models are crucial. In this paper we present an approach to model the mixing of scalars, e.g. species mass fractions or temperature, based on considering one‐dimensional parameterized scalar profiles (PSP). (© 2005 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Near‐wall gas‐droplet flows with liquid‐film formation
Authors: Osiptsov Alexander 
Published: December 2005

AbstractA self‐consistent asymptotic theory of a near‐wall aerodisperse flow with the formation of a liquid film due to inertial deposition of liquid droplets on the body surface is constructed. With the reference to the examples of low‐speed mist flows near plane and curvilinear solid surfaces, asymptotically different situations are analyzed. The two‐fluid equations of the mist flow are solved simultaneously with the equations of the liquid film, on the outer edge of which the distributed mass, momentum, and energy fluxes (found from the solution of the outer problem) are specified. It is shown that depending on the values of governing parameters the flow in the film should be described by either boundary‐layer or creeping‐flow equations in the layer with a priori unknown thickness. For the film on the frontal surface of a blunt body, the film thickness and the friction and heat transfer coefficients are found numerically. The conditions in which the presence of the film significantly reduces the heat fluxes are determined and the possibility of the realization of steady‐state flow regimes in the film is demonstrated. (© 2005 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Influence of velocity distribution in the multiphase flow on the building of aerobic granules in a Sequencing Batch Reactor (SBR)
Authors: Zima Bogumila Ewelina , Kowalczyk Wojciech , Hartmann Christoph , Delgado Antonio 
Published: December 2005

AbstractIn present contribution a study is presented, where fluid dynamic measurements are used to observe multiphase flow pattern in a bioreactor. It can be shown that hydrodynamic effects have a major influence on the formation, shape and size of Granular Activated Sludge (GAS) in a Sequencing Batch Reactor (SBR) under aerobic condition. In order to analyse multiphase flow pattern (water, air, granules) in the bioreactor in‐situ techniques with optical measurements are applied. LASER IIIB and video lamp are used as a light source. Due to a transient spatial velocity distribution in the bioreactor our experiments are carried out in different levels of SBR. Tracer particles are employed to visualise the fluid flow pattern. Velocity field of the liquid phase in the bioreactor is determined by use of PIV method (Particle Image Velocimetry). PTV (Particle Tracking Velocimetry) is implemented to observe velocity field of individual granules (solid phase). (© 2005 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Interaction of infinite thin elastic cylindrical shell and pulsating spherical inclusion in potential subsonic flow of ideal compressible liquid
Authors: Dzyuba Victoria 
Published: December 2005

AbstractIn the present paper a method is proposed to investigate behaviour of the axis symmetric system consisting of an infinite thin elastic cylindrical shell, filled by potential flow of ideal compressible liquid and containing pulsating spherical inclusion. This coupled problem is considered in the framework of classical mechanics models: linear potential flow theory and thin elastic shells theory based on the Kirchhoff ‐ Love hypotheses. The approach suggested consists in possibility of rewriting general solution of the corresponding mathematical physics equations from one to the other coordinate system. It enables to satisfy boundary conditions on both the spherical and the cylindrical surfaces and to get an exact analytical solution (as a Fourier series) of the coupled interaction problem. (© 2005 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Triple‐deck regularization of weak laminar hydraulic jumps in a two layer shallow water flow
Authors: Kluwick A. , Viertl N. 
Published: December 2005

AbstractThe inviscid, weakly nonlinear, shallow‐water limit of the Navier–Stokes equations leads to a hyperbolic conservation law. In certain cases of a two‐layer flow the flux‐function is non‐convex, thus leading to the possibility of shocks (in physical terms hydraulic jumps) violating the Oleinik‐entropy criteria, so called non‐classical shocks. To rule out the inadmissible shocks their internal structure is studied, based on an asymptotic approach consistent with the Navier–Stokes equations. This leads to a triple‐deck problem with a novel, non‐linear interaction equation in the form of a forced, extended KdV‐equation. The limit of vanishing and weak influence of the displacement effect is studied analytically, and in addition representative numerical solutions of the full problem are presented. Of particular interest is a solution, which has a pronounced, almost vanishing minimum in he wall shear. Its local structure is studied in some detail. (© 2005 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Coupling Boundary Elements to a Raytracing Procedure using the Singular Indirect Method
Authors: Langer S. , Hampel S. 
Published: December 2005

AbstractThe coupling of Boundary Elements and a raytracing procedure is presented here. Such a hybrid method is best suited to the study of realistic outdoor sound propagation problems: The noise often acts in a domain where many objects like buildings or sound insulation walls scatter the sound. Thus, diffraction has to be taken into account. BEM is well suited. To study the effects of this noise on a sound receiver far away, raytracing may be preferable for such application, because refraction can be implemented more easily. Hence, a Boundary Element Analysis is performed in noisy nearfield regions, a raytracing procedure at a larger distance from the sound sources. First, the direct Boundary Element algorithm is applied to determine the sound pressure at interface points. Second, a singular indirect Boundary Element formulation is used to find intensities of point sources on the same interface which produce the previously determined sound pressure. Finally, these sound intensities are the input data for the raytracing procedure. (© 2005 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Marangoni‐driven liquid films rising out of a meniscus onto a nearly‐horizontal substrate
Authors: Evans P. L. , Münch A. 
Published: December 2005

AbstractWe revisit the situation of a thin liquid film driven up an inclined substrate by a thermally induced Marangoni shear stress against the opposing parallel component of gravity. In contrast to previous studies, we focus here on the meniscus region, in a case where the substrate is nearly horizontal. Our numerical simulations show that the time‐dependent lubrication model for the film profile can reach a steady state in the meniscus region that is unlike the monotonic solutions investigated earlier. A systematic investigation of the steady states of the lubrication model is carried out by studying the phase space of the corresponding third‐order ODE system. We find a rich structure of the phase space including multiple non‐monotonic solutions with the same far‐field film thickness. (© 2005 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Lp – LqEstimates To The Solution Of The Cauchy Problem For Partial Differential Equations Describing Non‐Simple Thermoelastic Materials
Authors: Gawinecki Jerzy , Łazuka Jarosław 
Published: December 2005

AbstractTheory of non‐simple materials is different from that of simple materials because in it the first strain gradient is taken into consideration as the constitutive variable.The consequence of this fact, from mathematical point of view, is that the equation of motion consists either of higher order derivatives of displacement (four order derivatives) and some material parameters can depend not only on the temperature and the gradient of displacement but also on the second derivative of displacement.We consider the system of partial differential equations describing non‐simple thermoelastic materials. This system consists of four scalar equations, three equations of motion and one of energy balance, describing the field of displacement and the temperature in an elastic body.Using the Fourier transform, we found the L p – L q time decay estimates of the solution of the Cauchy problem for the system of equation describing the non‐simple thermoelastic materials, being important for proving the global‐in‐time solution of this problem. (© 2005 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)