bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ankylosing Spondylitis and Spondylitis Accompanying Ulcerative Colitis, Regional Enteritis, Psoriasis and Reiter's Disease. A Comparative Study
Authors: McEwen Currier , Ditata Dominick , Lingg Claire , Porini Anna , Good Armine , Rankin Thomas 
Published: February 2007

AbstractA comparative clinical and roentgenologic study of spondylitis accompanying various diseases has revealed features which permit placing them in two descriptive categories. Ankylosing spondylitis and spondylitis associated with ulcerative colitis and regional enteritis resemble each other closely and constitute one category. Spondylitis associated with psoriasis and Reiter's disease also resemble each other closely but have features which distinguish them from the first category.
Incidence of Antibodies to Double‐Stranded RNA in Systemic Lupus Erythematosus and Related Diseases
Authors: Schur Peter H. , Stollar B. David , Steinberg Alfred D. , Talal Norman 
Published: February 2007

AbstractSera from patients with systemic lupus erythematosus (SLE) and related diseases were examined for antibodies to double‐stranded RNA (DSRNA) by precipitation, complement fixation and radioactive antigen binding. While only 6% of normals had antibodies to DSRNA, 51% of patients with SLE had these antibodies. A low incidence of these antibodies was seen in patients with progressive systemic sclerosis, juvenile rheumatoid arthritis, myasthenia gravis, thyroiditis, multiple myeloma, rheumatoid arthritis, Sjögren's syndrome, drug‐induced SLE and various forms of liver disease. These antibodies reacted to synthetic and naturally occurring DSRNA, but not to single‐stranded RNA or DNA. As DSRNA is found in cells primarily during viral replication, these antibodies may represent a response to viral infection.
Synovial fluid pH, lactate, oxygen and carbon dioxide partial pressure in various joint diseases
Authors: Treuhaft Paul S. , McCarty Daniel J. 
Published: February 2007

AbstractFifty‐five samples from knee joints of 44 patients with a wide variety of joint diseases were analyzed by routine gross and microscopic examination, and for pH, pO2 and pCO2; 18 fluids were analyzed for lactate. pO2 values ranged from 8–78 mm Hg. Lower values were found generally in fluids of the inflammatory type. pH values ranged between 6.6 and 7.41 units and correlated poorly with pO2. pCO2 ranged between 34 and 150 mm Hg. pO2 correlated poorly with pCO2 (r = −0.22) but better with lactate (r = −0.67). In the same 18 samples, lactate correlated better with pH (r = −0.9) than did pCO2 (r = −0.38). No single entity could be identified with a given degree of physiologic abnormality. These changes appear to be nonspecific. The good correlation between lactate and both pH and pO2 suggests that anaerobic glycolysis by an anoxic synovium may be the most important underlying factor.
Reactions of systemic lupus erythematosus sera with histone fractions and histone‐DNA complexes
Authors: Stollar B. David 
Published: February 2007

AbstractTwenty‐five of 85 SLE sera reacted by complement‐fixation with free histones or histone‐DNA complexes in the absence of, or after absorption of, antibodies to native DNA. Of 10 sera reacting with free histones, eight showed marked selectivity for the lysine‐rich F1 histone. Fifteen sera reacted with histone‐DNA complexes but not with free histone or DNA; six of these showed marked selectivity for the F1 histone. Reactions with chromatin were varied. Of 38 random sera from a clinical laboratory, one reacted specifically with F1 histone‐DNA complexes. Poly‐L‐lysine inhibited the reactions of two SLE sera with F1 histone.
The effect of chrysotherapy on trace metals in patients with rheumatoid arthritis
Authors: Niedermeier William , Prillaman William W. , Griggs James H. 
Published: February 2007

AbstractBlood serum specimens from patients with rheumatoid arthritis who had never received chrysotherapy, patients with rheumatoid arthritis who had been receiving chrysotherapy for a period of 18 months or more and normal volunteers were analyzed by emission spectroscopy for eight trace elements. Compared with the normal volunteers, the mean concentrations of copper, molybdenum, manganese, tin, barium and cesium were elevated in blood serum from patients with rheumatoid arthritis who had never received chrysotherapy. Chrysotherapy resulted in a decrease in molybdenum, manganese, tin, barium and cesium. The mean concentrations (compared with the normal) of zinc and iron were lower in blood serum of patients with rheumatoid arthritis who had never received gold therapy. Chrysotherapy had no apparent effect on iron or zinc.
Glomerular cytoplasmic tubular structures in renal biopsies of patients with systemic lupus erythematosus and other diseases
Authors: Hurd Eric R. , Eigenbrodt Edwin , Worthen Howard , Strunk Stanley S. , Ziff Morris 
Published: February 2007

AbstractVirus‐like structures were present in all of 42 renal biopsies from 35 patients with SLE, five of whom had normal kidney tissue by light microscopy. Structures were also present in biopsies from 24 of 113 patients with renal disease other than SLE who had been selected at random. Fourteen of these were children, and three had normal kidney tissue by light microscopy. In biopsies from eight normal volunteers, there was no evidence of the structures. Although the structures were uniformly present in the kidneys of patients with SLE, they were not specific for SLE.
Azathioprine in the treatment of systemic lupus erythematosus. A controlled study
Authors: Sztejnbok Maurice , Stewart Ann , Diamond Herbert , Kaplan David 
Published: February 2007

AbstractSixteen patients with systemic lupus erythematosus have been observed for from 1 to 4 years while taking prednisone plus azathioprine in a dose of 2.5 mg/kg/day and compared to 19 patients with systemic lupus erythematosus managed with prednisone alone for a similar period. Patients receiving azathioprine showed a decreased mortality and morbidity, required less daily prednisone than the control group, exhibited no increased tendency to develop infection, had fewer exacerbations of their disease and maintained better renal function. Discontinuation of the azathioprine was associated with severe exacerbations of disease. The toxicity of azathioprine was minimal.
Effects of colchicine on collagenase in cultures of rheumatoid synovium
Authors: Harris Edward D. , Krane Stephen M. 
Published: February 2007

AbstractRheumatoid synovium, cultured in vitro in media not enriched with serum, synthesized and released a specific collagenase. This enzyme appeared in measurable quantities only after three or more days of culture. Enzyme activity correlated well with hydroxyproline content in the culture media, indicating that extracellular matrix collagen in synovial explants was being degraded. Collagenase activity was found to be 2 to 10 times greater when colchicine (0.1 μg/ml) was added to the culture media. This stimulation of enzyme was dependent upon cells which could metabolize glucose and synthesize RNA; it was not dependent upon continued addition of colchicine to fresh culture media. Colchicine was found to depress 14CO2 production from glucose‐6‐14C, whereas lactate formation and 14CO2 evolution from glucose‐1‐14C were less markedly depressed. Mitotic figures were not seen in cells of tissue cultures in the absence of serum, nor was mitotic arrest observed in colchicine‐treated tissue. The effect of colchicine was not mediated by decreased degradation of the enzyme in culture nor by stimulation of release of stored enzyme, but was associated with an increase in radioactive leucine incorporation into several proteins synthesized by the cell, including collagenase.
Serum and synovial fluid IgG, IgA and IgM antigammaglobulins in rheumatoid arthritis
Authors: Panush Richard S. , Bianco Nicolas E. , Schur Peter H. 
Published: February 2007

AbstractAntigammaglobulins of IgG, IgA and IgM classes were measured in normal individuals and in patients with osteoarthritis or rheumatoid arthritis. Serum IgG and IgA and synovial fluid IgG antigammaglobulin levels were significantly higher in patients with rheumatoid arthritis than in other individuals, with highest levels occurring in patients with positive latex fixation tests. IgM antigammaglobulins were elevated only in patients with latex positive rheumatoid arthritis. Increased serum levels of IgG, IgA and IgM antigammaglobulins were each associated with clinical findings of severe rheumatoid arthritis. Increased levels of serum and synovial fluid IgG and IgM antigammaglobulins were each associated with diminished serum and synovial fluid complement levels.
Isoniazid acetylatlon rate and development of antinuclear antibodies upon isoniazid treatment
Authors: Alarcón‐Segovia Donato , Fishbein Eugenia , Alcalá Hilda 
Published: February 2007

AbstractA large proportion of tuberculous patients on isoniazid develop antinuclear antibodies, and an occasional one may also develop overt systemic lupus erythematosus. To determine if the development of antinuclear antibodies in such patients is related to the rate of acetylation of the drug, which is determined phenotypically, we studied both isoniazid acetylation rate and serum antinuclear antibodies in tuberculous patients who had been on isoniazid. Of 153 such patients studied, 78 were phenotypically slow and 75 were phenotypically fast isoniazid acetylators. Antinuclear antibodies to whole nuclei, nucleoprotein, soluble nucleoprotein and isoniazid‐altered soluble nucleoprotein were detected by complement fixation tests more frequently in slow than in fast acetylators but this difference was not statistically significant. They also occurred more frequently in females than in males. Antinuclear antibodies that develop after prolonged isoniazid intake may be elicited by in vivo alteration of nucleoprotein by isoniazid and modestly influenced in their frequency by sex and by the pharmacogenetics of isoniazid.
Metabolism of the third component of complement (C3) in patients with rheumatoid arthritis
Authors: Weinstein Arthur , Peters Keith , Brown David , Bluestone Rodney 
Published: February 2007

AbstractThe metabolism of radioiodinated purified C3 was studied in 8 patients with classical seropositive rheumatoid arthritis, 1 patient with osteoarthritis, and 1 normal subject. An increased fractional catabolic rate and a decreased half‐life was found in 2 subjects. Both these patients showed evidence of rheumatoid necrotizing vasculitis, and these results suggest an immune‐mediated pathogenesis for this lesion. The high serum level of C3 found in some rheumatoid patients is due to an increased rate of C3 synthesis.
Septic arthritis, gout, pseudogout and osteoarthritis in the knee of a patient with multiple myeloma
Authors: Smith J. Robert , Phelps Paulding 
Published: February 2007

AbstractThis report describes a 79‐year‐old Negro woman with multiple myeloma in whom a pneumococcal infection occurred in a previously asymptomatic but severely osteoarthritic knee. Treatment with penicillin was associated with rapid partial resolution of the inflammation. Synovial fluid cultures initially contained a Type 22 pneumococcus but were negative after the first hospital day. On the eleventh hospital day, synovial aspirate revealed intra‐ and extracellular crystals not previously present. There were crystals with strong negative birefringence, digestible by uricase, which were morphologically typical of monosodium urate crystals. Also present were many monoclinic and triclinic crystals with weak positive birefringence, morphologically typical of calcium pyrophosphate dihydrate. This patient's clinical course was consistent with the possibility that enzymes, released during the early septic process, digested cartilage matrix, releasing, into the joint space, crystals that had been deposited previously in a protected intracartilagenous site.
Immunopathologic Study of Sural Nerves in Rheumatoid Arthritis
Authors: Conn Doyt L. , McDuffie Frederic C. , Dyck Peter James 
Published: February 2007

AbstractIn 5 patients with rheumatoid neuropathy of vascular etiology, nerve fibers showed axonal degeneration. One patient with acute neuropathy, not receiving corticosteroids, had acute necrotizing arteritis; IgG, IgM, and β 1C, but not albumin, were found in vessel walls. Patients with chronic neuropathy who received corticosteroids before biopsy had proliferative endarteritis with fibrinogen but not immunoglobulins in the vessels. The proliferative endarteritis of rheumatoid arthritis probably represents the healed stage of an acute arteritis.
The γG subclass of antinuclear and antinucleic acid antibodies
Authors: Schur Peter H. , Monroe Margaret , Rothfield Naomi 
Published: February 2007

AbstractSelected sera from patients with systemic lupus erythematosus (SLE) and progressive systemic sclerosis (PSS) were studied to determine the γG subclass in which the antibody activities were present. These sera were known to contain γG antibodies to nuclear antigens, cytoplasmic antigens or nucleic acids. Antibodies to DNA and those giving a peripheral pattern in the fluorescent antinuclear antibody test (ANF) primarily were of the γG1 and γG3 types; antibodies giving a speckled pattern primarily were of the γG3 type; and antibodies giving a diffuse pattern in the ANA test primarily were of the γG3 type, and less so of the γG1 type. These findings indicate: that antibodies to some nuclear antigens and nucleic acids may be restricted to certain γG subclasses; and that anti‐DNA antibodies, which have been most strongly associated with low serum complement levels and active lupus nephritis, are found primarily in those γG subclasses which fix complement most efficiently—namely, γG1 and γG3.
The influence of temperature on the solubility of monosodium urate
Authors: Loeb John N. 
Published: February 2007

AbstractThe limited solubility of monosodium urate in the presence of physiological sodium concentrations is shown to fall sharply with decreasing temperature. It is suggested that this phenomenon may play a role in determining the clinically observed distribution of tophi and the susceptibility of certain joints to acute gouty arthritis.
Adjuvant effects on poly I poly C in New Zealand mice
Authors: Jacobs M. E. , Steinberg A. D. , Gordon J. K. , Talal N. 
Published: February 2007

AbstractThe effects of polyinosinic polycytidylic acid (poly l poly C), a known adjuvant, were studied in New Zealand and C57B1/6 mice, using sheep erythrocytes (SRBC) as antigens. The control C57B1/6 mice showed a 3.1 to 6.7 fold increase in plaque forming cells (PFC) to SRBC when poly l poly C was given with the SRBC. The New Zealand mice (NZB/NZW F1 hybrids) showed very little increase in PFC with the poly l poly C. These studies suggest that the New Zealand mice are already maximally stimulated to respond to SRBC and that additional adjuvant cannot augment their response.
Susceptibility of cultures of rheumatoid tissues to rubella virus infection
Authors: Parker Michael D. , McCollum Donald E. , Kerby Grace P. 
Published: February 2007

AbstractPrevious reports by others of resistance of cultured rheumatoid synovial cells to experimental virus infection prompted extension of such studies to rheumatoid fibroblasts from other tissues. Strains of cells derived from rheumatoid skin, synovium and a nodule and from nonrheumatoid skin and synovium were inoculated in vitro with rubella virus (RV). All of the tissues studied proved equally susceptible to RV infection.
Noncytopathogenicity of rubella vaccine strain HPV‐77 for synovial cells
Authors: Ford Denys K. 
Published: February 2007

AbstractThe rubella vaccine strain HPV‐77 failed to produce a cytopathogenic effect in 6 rheumatoid and 13 nonrheumatoid synovial cell cultures, the inoculum dosage being 1 to 5 TCID50 per synovial cell.
The pathogenesis of chronic inflammation in experimental antigen‐induced arthritis. I. The role of antigen on the local immune response
Authors: Cooke T. Derek , Jasin Hugo E. 
Published: February 2007

AbstractUsing the model described by Dumonde and Glynn in which a chronic synovitis is induced by the intraarticular injection of antigen in previously immunized rabbits, marked chronic local synthesis of immunoglobulin comparable to that of lymph nodes and spleen was found as long as 6 weeks after the arthritis was induced. Between 30 and 40% of this newly synthesized immunoglobulin was accounted for as specific antibody to the locally injected antigen. Very low levels of synthesis were found in the spleen, control synovia and regional lymph nodes not draining immunized sites. The circulating antibody levels at the time of induction showed a positive correlation (r = 0.66) with the severity of the subsequent histologic findings in the synovium. The fate of the intraarticular antigen was studied in arthritic and control animals. There was a selective local retention of antigen in animals previously immunized with the homologous antigen. The retained intraarticular antigen was eliminated very slowly, with a half‐life of over 20 days. These data indicate that the chronic synovial inflammatory response is associated with a chronic local immune response in which prolonged active synthesis of immunoglobulin and specific antibody directed against the locally retained inducing antigen takes place.
Gold metabolism in patients with rheumatoid arthritis treated with gold compounds—reinvestigated
Authors: Mascarenhas Bento R. , Granda Jose Luis , Freyberg Richard H. 
Published: February 2007

AbstractAbsorption of gold from injected sites occurs rapidly, reaching its peak in blood between 4 and 6 hours. In plasma, 95% of gold is bound to albumin. Three patients that were studied from the beginning of weekly therapy showed a progressive stepwise rise in plasma gold levels up to the sixth week. Urinary excretion was greatest during the first day postinjection while fecal excretion was greatest during the middle of the week. The blood levels, as well as excretion, varied from patient to patient. Patients on maintenance therapy excreted 39, 16, 12 and 10% of the injected dose in the first, second, third and fourth weeks postinjection, respectively. There were no significant differences in blood gold levels in patients who showed a good therapeutic response, no therapeutic benefit or toxicity.
Synovitis of recent onset. A clinicopathologic study during the first month of disease
Authors: Schumacher H. Ralph , Kitridou Rodanthi C. 
Published: February 2007

AbstractNine of 24 patients studied during the first month of synovitis subsequently fulfilled diagnostic criteria for adult or juvenile rheumatoid arthritis. Most showed prominent synovial vascular lesions and inflammation that rarely included plasma cells. Rheumatoid factor titers were low, but gammaglobulin levels were often elevated. Synovial fluid leukocyte counts were generally lower than in chronic RA, and synovial membrane inflammation was seen even with noninflammatory effusions. Nine patients had a transient synovitis not fitting any known disease entity.
The effect of systemic corticosteroids on rabbit articular cartilage
Authors: Mankin Henry J. , Zarins Antra , Jaffe William L. 
Published: February 2007

AbstractRabbits were treated for up to 9 weeks with daily doses of cortisone. Cartilage from the distal femur was studied biochemically at regular intervals, and no change in the content of DNA but a significant and progressive decline in the concentration of hexosamine were noted. In vitro incorporation of 35SO4 and 3H‐glycine was depressed markedly. Because the test animals lost 25% of their body weight, a separate group of starved controls were studied and the changes noted were similar to those seen with corticoid treatment but were not as marked.
Reticulohistiocytosis. Remission after cyclophosphamide therapy
Authors: Hanauer Lonnie B. 
Published: February 2007

AbstractA 57‐year‐old woman developed joint pain, deformity and cutaneous nodules. Reticulohistiocytosis was diagnosed after skin biopsy. Nodule formation and progressive arthritis continued for almost 2 years but appeared to cease when treatment with cyclophosphamide began.
Salicylate hepatotoxicity in patients with juvenile rheumatoid arthritis
Authors: Rich Robert R , Johnson John S 
Published: February 2007

AbstractSalicylates were administered to 6 patients with juvenile rheumatoid arthritis in doses sufficient to produce a serum salicylate level in excess of 25 mg/100 ml. All 6 patients developed elevations of serum glutamic oxaloacetic transaminase and serum glutamic pyruvic transaminase. In addition, 4 patients had other evidence of hepatic dysfunction. Abnormalities were dose‐related and were reversible upon lowering the salicylate dose. Liver biopsies performed in 2 patients revealed a mononuclear cell infiltrate of portal triads in both and scattered single cell necrosis in the parenchyma in 1 case.
Immunologically induced acute synovitis in rabbits studies of immune complexes in synovial fluid
Authors: Roger Hollister J , Liang George C , Mannik Mart 
Published: February 2007

AbstractLarge antigen‐antibody complexes that are selectively removed from circulation were not selectively removed when injected into the knees of a normal rabbit. The subsequent selective removal of the complexes depended on the influx of neutrophils. Nevertheless, macrophages of the normal synovial lining were able to phagocytize some immune complexes. When antigen and antibodies were administered separately by intravenous or intraarticular routes, little or no soluble complexes were found in synovial fluid, and most of the antigen‐antibody union was thought to occur in the synovial tissue.
Experimental bedsonial arthritis
Authors: Edwards Smith D , James Paul G , Schachter Julius , Engleman Ephraim P , Meyer Karl F 
Published: February 2007

AbstractA bedsonia isolated from the joint of a patient with Reiter's syndrome produced arthritis when injected into the knees of Macaca mulatta or New Zealand white rabbits. The monkeys developed an acute self‐limited arthritis that resolved within 11 to 49 days. Symptoms were limited to the injected joints. Reinoculation of the same joints produced a similar arthritis, indicating that repeated exposure neither enhances nor diminishes clinical response. Repeated intraurethral inoculation produced urethritis in 1 macaque, and the organism was recovered from the urethra. Infected rabbits developed a chronic arthritis. Bedsonial infection and disease in the rabbit were disseminated from joint to eye and from joint to selected viscera. Viable multiplying organisms were essential to produce arthritis, and treatment with tetracycline before agent inoculation prevented disease. Bedsonial organisms other than those recovered from Reiter's syndrome also caused arthritis when injected into the knees of monkeys or rabbits.
Immune response of patients with rheumatoid arthritis during cyclophosphamide treatment
Authors: Curtis John E , Sharp John T , Lidsky Martin D , Hersh Evan M 
Published: February 2007

AbstractThe immune response was studied in 21 patients with rheumatoid arthritis. Eleven had been randomly assigned to receive cyclophosphamide, 50 to 75 mg/day, and 10 to receive a placebo. Immunologic responsiveness was assessed by delayed hypersensitivity skin testing, immunoglobulin levels, in vitro lymphocyte blastogenesis and the primary immune response. All patients had elevated levels of IgG, normal or low IgA and IgM. Delayed hypersensitivity and in vitro lymphocyte blastogenic responses after immunization with the primary antigens Keyhole limpet hemocyanin and the amino acid copolymer (GLAT) were normal. Keyhole limpet hemocyanin and GLAT hemagglutinin titers were lower than normal due to decreased IgG and IgM formation. Treatment for 8 weeks with cyclophosphamide, 50 to 75 mg/day, did not alter the clinical status of the patients and had no detectable effect on their immune reactivity.