bluuebunny/crossref_metadata_2025_split huggingface dataset:
High rate of high-risk human papillomavirus among benign and breast cancer patients in Ethiopia
Authors: Belachew Esmael Besufikad , Desta Adey Feleke , Mulu Andargachewu , Deneke Dinikisira Bekele , Tefera Dessalegn Abeje , Alemu Ashenafi , Anberber Endale , Beshah Daniel , Girma Selfu , Sewasew Dareskedar Tsehay , Tessema Tesfaye Sisay , Howe Rawleigh 
Published: March 2024

Introduction
There have been numerous studies that showed the presence of human papillomavirus (HPV) in breast cancer; nonetheless, there is ongoing debate regarding their association. Given few studies in Ethiopia, we aimed to investigate the magnitude of HPV infection in Ethiopian breast cancer patients.

Methods
A total of 120 formalin-fixed paraffin-embedded (FFPE) tissue blocks were obtained, and basic demographic, clinical, and histological data were collected from medical records. DNA was extracted from archived FFPE breast tissue specimens using GeneRead DNA FFPE Kit. The AnyplexTM II HPV28 Detection Kit (Seegene, Korea) was used to detect HPV by following the manufacturer’s instructions. The SPSS Version 25 was used to enter and analyze data.

Results
Among the 120 study participants; HPV (both high-risk and low-risk) was detected in 20.6% of breast cancer and 29.6% of non-malignant breast tumors. The most common genotype was the high-risk HPV 16 genotype. The frequency of HPV was nearly 10-fold higher in estrogen receptor-positive than ER-negative breast cancer. The percentage of HPV in the luminal (luminal A and luminal B) breast cancer subtypes was also much higher than in the non-luminal subtypes (HER-2 enriched and triple-negative breast cancer).

Conclusion
This study did not find a significant difference in HPV expression between breast cancer and non-malignant breast tumors; however, the higher percentage of HPV in ER-positive compared to ER-negative breast cancer warrants further attention.
Characteristics of cervicovaginal microflora at different cervical maturity during late pregnancy: A nested case-control study
Authors: Chen Ping , Hu Tingting , Zheng Zheng , E. Garfield Robert , Yang Jinying 
Published: March 2024

Objective
The mechanism of cervical ripening in late pregnancy is still unclear. The vaginal microbiome has been reported to correlate with the preterm birth and short cervix in pregnant women. However, the associations between the cervical maturity and the vaginal microbiome are still poorly understood. We aim to analyze the cervicovaginal microflora in women with ripe cervix and in those who are unripe when delivering at term.

Methods
Cervicovaginal swabs were collected between 40 and 41 weeks of gestation from the following 2 different groups of patients: ripe group (n = 25) and unripe group (n = 25). Samples were tested using 16S ribosomal RNA gene high-throughput sequencing and analyzed by bioinformatics platform.

Results
This study highlights the relationship between cervical maturity during late pregnancy and the composition of the cervicovaginal microflora. Both α- and β-diversity analyses demonstrated significant differences between women with a ripe cervix and those with an unripe cervix. Notably, the Lactobacillus profile was found to be closely linked to cervical maturity. There was a significant difference in the vaginal community state type, with CST IV being more prevalent in women with an unripe cervix. Furthermore, the association between CST IV and the unripe cervix group, as indicated by the odds ratio of 8.6, underscores its relevance in evaluating cervical maturity, when compared to other Lactobacillus-dominant community state types. Additionally, several bacterial taxa, particularly Lactobacillus, exhibited differential relative abundances between the two groups.

Conclusion
This study provided significant evidence regarding the relationship between the vaginal microbiome and cervical maturity, highlighting the differential diversity, community state types, and specific bacterial taxa, such as Lactobacillus, that are associated with cervical maturation status. These findings contributed to our understanding of the dynamics of the cervicovaginal microflora during late pregnancy and its implications for cervical health.
Functions of Word Play in a Comedy Television Show (Based on Good Omens TV series)
Authors: Nukhov Salavat , Voytsekh Ksenia 
Published: March 2024

Despite the great interest of scientists in word play, this phenomenon is still insufficiently studied. Many researchers highlight the comic function as the basis for word play. In this study, word play is viewed as the intentional use of a non-standard language code in order to express the inner world of the speaker, which is not always associated with the creation of a comic effect. The subject of this research deals with cases of language play in the Good Omens comedy series. Film discourse can be interpreted as a reflection of the current state of culture and the society, as well as of the language, which became a decisive factor in the choice of research material. The author of the article comes to the conclusion that the comic function does not play a key role in the use of word play in a comedy television series, being exceeded in frequency by such functions as characterological, meaning-forming and expressive. The article contains numerous material from a modern television series, which gives one the ground to realize the relevance of the conclusions.
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Verbal and Nonverbal Ways of Presenting Information in School Discourse (Linguo-Semiotic Aspect)
Authors: Victoria Chernova 
Published: March 2024

The article covers the study of verbal, non-verbal and mixed type presentemes in the context of school discourse. The text of the lesson is presented as a semiotic heterogeneous discourse. Our research contains the material of particular teachers’ lesson plans from Catherine Gymnasium 36 in Krasnodar. The methodological basis of the study is a need-based information approach to phenomena of school communication which allows to define modes of coexistence of visual presentemes with verbal components of a lesson. The results of the study led to conclusion that school discourse has special features, which make it possible to distinguish it as a particular type of institutional discourse. The presence of verbal, non-verbal and mixed type presentisms in it proves that the lesson is a semiotic heterogeneous text. The impact on the pupil is one of the teacher’s speech functions, which is realized more effectively if the verbal level of communication is accompanied by a non-verbal component.
MASS TRANSFER IN THE BIOREACTOR DURING GAS DISPERSION FROM THE STIRRER VORTEX CAVITY
Authors: Voynov Nikolay Aleksandrovich , Frolov Alexander Sergeevich , Bogatkova Anastasia Viktorovna , Zemtsov Denis Andreevich , Chernov Vyacheslav Andreevich 
Published: March 2024

Gas-liquid bioreactors in which the introduction of the gas substrate in the culture liquid is carried out from the vortex cavity formed by the rotation of the stirrer. In order to simplify the design and intensify mass transfer a new method of dispersing the gas substrate from the vortex cavity is proposed and studied. It consists in maintaining local zones with reduced pressure in the liquid behind the rotating paddles and creating the necessary conditions for the introduction of the gas substrate. On the basis of numerical simulation the pressure is calculated and the zones of low pressure in liquid behind the stirrer paddles are determined. The value of differential pressure necessary for gas dispersion has been estimated. The angular velocity of liquid rotation depending on the number of partitions on the apparatus wall and the number of mixer revolutions is presented. The gas content in the liquid during the implementation of the investigated method has been determined. The average surface diameter of gas bubbles and interfacial surface of gas-liquid medium were calculated from experimental data. The power spent on stirring in the apparatus has been established and the power criterion with regard to gas content has been determined. Mass transfer at intensive gas dispersion from gas vortex cavity into liquid has been investigated. Criterion dependence for calculation of mass transfer coefficient is presented, taking into account energy dissipation spent on mixing and interfacial surface. The fields of application of bioreactor with new method of gas dispersion are shown.
Serum biomarkers associated with liver fibrosis in patients with type 2 diabetes
Authors: Krasner Y. A. , Romanov V. V. , Fazullina O. N. , Osipenko M. F. , Klimontov V. V. 
Published: March 2024

BACKGROUND: The diagnosis of liver fibrosis is an important task in the management of patients with non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes. The currently used diagnostic methods have a number of disadvantages such as invasiveness and high cost, or insufficient sensitivity and specificity. Therefore, the search for new non-invasive markers of liver fibrosis remains an actual challenge.AIM: To assess a diagnostic value of serum growth differentiation factor-15 (GDF-15), microfibril-associated glycoprotein 4 (MFAP-4), collagen type IV alpha1 (COL4alpha1), Mac-2 binding protein (M2BPGI) and chitinase-3-like protein 1 (YKL-40) as markers of liver fibrosis in patients with type 2 diabetes and NAFLD.MATERIALS AND METHODS: A single center cross-sectional observational study was performed. The study included 74 patients, 23 men and 51 women, aged 18 to 74 years. Liver elastography was used as reference method for the fibrosis evaluation. APRI and fib-4, non-invasive fibrosis indices, were assessed. Serum concentrations of GDF-15, MFAP-4, COL4alpha1, M2BPGI, and YKL-40 were determined by ELISA. ROC analysis was used to evaluate the sensitivity and specificity of serum markers for the diagnosis of the liver fibrosis.RESULTS: Liver fibrosis stage 1 was verified in 16 subjects, stage 2 in 12, stage 3 in 7, and stage 4 in 19. Patients with advanced liver fibrosis (stages 3–4), compared with those without severe fibrosis (stages 0–2), had higher levels of GDF-15 (p=0.003), COL4alpha1 (p=0.007), and YKL-40 (p=0.04). Patients with stage 1-2 liver fibrosis had higher levels of COL4alpha compared to those without any signs of fibrosis (p=0.02). There were no significant differences in the level of MFAP-4 and M2BPGI between patients with different severity of fibrosis. According to the ROC analysis, GDF-15, COL4alpha1 and YKL-40 have diagnostic value in the detection of severe liver fibrosis comparable to that of the APRI and fib-4 indices.CONCLUSION: GDF-15, COL4alpha1 and YKL-40 could be considered as promising non-invasive markers of liver fibrosis in patients with type 2 diabetes and NAFLD.
GENDER CONSTRUCTION IN FAMILY REALITY: A CASE STUDY OF THE ROLE OF POST DIVORCE FAMILY INTERACTIONS IN INDONESIA
Authors: Dewi Kartika Sari , Ginanjar Adriana , Nugroho Fentiny , Anggita Devina 
Published: March 2024

The purpose of this study was to highlight the dynamics of gender construction in divorced families. This study used a qualitative method with a case study design on eight mothers-youths from divorced families. In contrast to previous research, this study identified the role of post-divorce family interactions in the construction of gender associated with their well-being. The study’s findings show that the gender scheme developed by youth is linked to patterns of interaction in the family after the parents’ divorce. Changes in parent roles and the presence of extended families contribute to their gender construction. There is an evaluation process that builds an understanding of dynamic gender roles in the family in order to understand the reality of the post-divorce family. Fathers who re-opened communication with their children, mothers as gatekeepers in communication and parenting, and mothers’ and children’s perceptions of the extended family all contributed to the evaluation process. Youth from divorced families face challenges in seeking well-being. They still believe that an intact family is ideal and that the presence of a responsible father is considered important for young people, while the presence of an extended family causes dilemmas in family interactions.
Hybrid method for noise rejection from breath sound using transient artifact reduction algorithm and spectral subtraction
Authors: Haider Nishi Shahnaj , Behera Ajoy K. 
Published: March 2024

Abstract

Objectives
Computerized breath sound based diagnostic methods are one of the emerging technologies gaining popularity in terms of detecting respiratory disorders. However, the breath sound signal used in such automated systems used to be too noisy, which affects the quality of the diagnostic interpretations. To address this problem, the proposed work presents the new hybrid approach to reject the noises from breath sound.

Methods
In this method, 80 chronic obstructive pulmonary disease (COPD), 75 asthmatics and 80 normal breath sounds were recorded from the participants of a hospital. Each of these breath sound data were decontaminated using hybrid method of Butterworth band-pass filter, transient artifact reduction algorithm and spectral subtraction algorithm. The study examined the algorithms noise rejection potential over each category of breath sound by estimating the noise rejection performance metrics, i.e., mean absolute error (MAE), mean square error (MSE), peak signal to noise ratio (PSNR), and signal to noise ratio (SNR).

Results
Using this algorithm, the study obtained a high value of SNR of 70 dB and that of PSNR of 72 dB.

Conclusions
The study could definitely a suitable one to suppress noises and to produce noise free breath sound signal.
Physical and mechanical response of porous metals composites with nano-natural additives
Authors: Hassan Zainab Kassim , Kseer Khamaal Mohsin 
Published: March 2024

Abstract
The mechanical and physical characteristics of composites are made of reinforced palm leaves and copper, the green palm leaves in nanoparticles forms once, and another sample from ash powder of palm leaves with copper powder metal as a matrix that was studied. First, a Cu metal was complemented with green palm leaf at a ratio (10:20:30)% on a sub-micron scale and second with the ash of palm leaves with the same ratio (10, 20, and 30)% and as nanoparticles. Apparent porosity, thermal conductivity, SEM, and compressive strength were carried out. It was noticed that adding additives to Cu causes its apparent porosity rise, porosity value of Cu samples supported with green palm leaves fibers was higher than that of Cu samples supported with palm leaves ash, and the highest percent of porosity was for the sample supported with 30% green palm leaves fibers which were 2.4%. It is also clear from the results that the increase in the percentage of additives led to a significant decrease in the thermal conductivity, as it decreased from 385 W/m K for the unsupported copper sample to 175 W/m K for the green copper supported sample, which was the lowest value, while the lowest value recorded for the palm leaves ash supported sample was 253 W/m K. The results of the compression test showed that the inverse relationship between the percentage of additives and the value of the compressive strength, as the lowest value of the compressive strength estimated at 23 MPa was recorded for the copper sample reinforced with 30% green palm leaves, and it is the same sample that recorded the highest value for porosity as mentioned before.
KORELASI PANJANG LENGAN DAN KEKUATAN OTOT LENGAN TEHADAP LEMPAR CAKRAM GAYA MENYAMPING ATLET KABUPATEN DEMAK
Authors: Santirossa Santi Rossa , Sahri Sahri 
Published: March 2024

Abstrak
Penelitian ini bertujuan untuk meninjau hubungan antara panjang lengan dan kekuatan otot lengan terhadap lempar cakram gaya menyamping. Penelitian ini adalah penelitian kuantitatif dimana metode penelitian yang digunakan adalah metode survei tes, dengan menggunakan tes dan pengukuran olahraga. Populasi pada penelitian ini adalah atlet-atlet lempar cakram di Kabupaten Demak, dimana sampel yang diambil adalah sebanyak 10 sampel yang diambil menggunakan metode total sampling. Pada hasil penelitian ini, diketahui bahwa terdapat hubungan yang signifikan pada panjang dan kekuatan otot lengan terhadap hasil lempar cakram gaya menyamping. Disimpulkan bahwa panjang lengan dan kekuatan otot lengan berpengaruh terhadap hasil lemparan.

Abstract
This study aims to examine the relationship between arm length and arm muscle strength against sideways style discus throwing. This research is a quantitative. where the research method used is a survey method, using sports tests and measurements. The population in this study were discus throwing athletes in Demak Regency, where 10 samples were taken using the total sampling method. In the results of this study, it is known that there is a significant relationship between the length and strength of the arm muscles on the results of sideways style discus throwing. It was concluded that the length and the strength of the arm muscles had an effect on the outcome of the throw.
ROBOPAS (ROBOT KIPAS) PENGEMBANGAN MEDIA LATIHAN MULTIBALL TENIS MEJA
Authors: Erlangga Dhaniel , Wibisana Muh Isna Nurdin , Royana Ibnu Fatkhu 
Published: March 2024

Abstrak
Penelitian ini dilatarbelakangi karena mahalnya alat Latihan multiball. Tujuan penelitian ini adalah mengembangkan media multiball dengan bahan dan biaya yang lebih terjangkau. Jenis penelitian ini adalah penelitian pengembangan atau Research and Development (R&D). Teknik pengambilan sampel menggunakan purposive sampling dengan jumlah 10 atlet saat uji coba skala kecil dan 20 atlet saat uji skala besar (uji lapangan). Dalam pelaksanaannya dilakukan lah tahapan tahapan dalam penelitiannya antara lain: potensi permasalahan, dikumpulkannya data, mendesain produk, memvalidasi desainnya, merevisi model, penguujian produk, perevisian produk, penguji cobaan pemakaiannya. Validasi dilakukan kepada ahli materi, ahli media, dan atlet HW SPORT. Teknik pengumpulan data menggunakan angket. Terdiri dari angket untuk ahli media sebagai bahan analisis alat dan angket untuk atlet sebagai respon terhadap kelayakan alat. Teknik analisis data menggunakan data deskriptif kualitatif dan deskriptif kuantitatif persentase. Hasil menunjukan media robopas yang “sangat layak” dipakai dalam menjadi media dalam pembelajaran maupun latihan olah fisik. Perolehan itu didapatkan dari validasi akhirnya dari a) ahli materi 90% atau layak; b) ahli media 83% atau layak; c) atlet pengujicobaan dilapangan sejumlah 88,8% atau layak. Kesimpulan penelitian ini adalah alat robopas sebagai media berlatih multiball layak digunakan. Alat ini dapat dimanfaatkan guna sarana bantu dalam pelatihan cabang olahraga permainan untuk menunjang prestasi.

Abstract
This research is motivated by the high cost of multiball training equipment. The purpose of this research is to develop multiball media with more affordable materials and costs. This type of research is research and development (R&D). The sampling technique used purposive sampling with a total of 10 athletes during a small-scale trial and 20 athletes during a large-scale test (field test). In its implementation, the stages of research are carried out, including: potential problems, collecting data, designing products, validating designs, revising models, testing products, revising products, testing trials of their use. Validation was carried out to material experts, media experts, and HW SPORT athletes. Data collection techniques using a questionnaire. Consists of a questionnaire for media experts as a tool for analysis and a questionnaire for responses to suitable tools. The data analysis technique used descriptive qualitative data and descriptive quantitative percentages. The results show that robopas media is "very feasible" to be used in learning media and physical exercise. The gain is obtained from the final validation from a) material expert 90% or worthy; b) 83% media expert or appropriate; c) test athletes in the field number 88.8% or eligible. The conclusion of this study is that the robopas tool as a multiball practice medium is feasible to use. This tool can take advantage of auxiliary facilities in the training of sports games to support achievement.
SURVEI ANTUSIASME DAN KETERTARIKAN MASYARAKAT DALAM BERSEPEDA DI KOTA SEMARANG
Authors: Surojo Saka Surya , Widiyatmoko Fajar , Kresnapati Pandu 
Published: March 2024

Abstrak
Penelitan ini adalah deskriptif kuantitatif. Tujuan penelitian ini adalah untuk mengetahui secara empirik tentang antusias dan ketertarikan masyarakat dalam bersepeda di Kota Semarang. Populasi semua orang yang mengikuti aktivitas bersepeda di Kota Semarang pengambilan sampel dengan menggunakan teknik random sampling. Instrumen tes menggunakan angket atau kuisioner. Hasil mengenai antusiasme dan ketertarikan masyarakat dalam bersepeda di Kota Semarang yang menunjukan kategori sangat tinggi berjumlah 10 orang atau 10% dari jumlah total, untuk kategoi tinggi berjumlah 11 orang atau 11%, untuk kategori sedang berjumlah 50 orang atau 50% hasil tersebut merupakan hasil terbanyak sedangkan untuk hasil kategori rendah berjumlah 26 orang atau 26% dan kategori sangat rendah berjumlah 3 orang atau 3%. Hasil tersebut dapat diartikan bahwa antusiasme dan ketertarikan masyarakat dalam bersepeda di Kota Semarangdapat dikatakan sedang dengan jumlah 50%.Simpulan dari penelitian mengenai antusiasme dan ketertarikan masyarakat dalam bersepeda di Kota Semarang dapat dikatakan sedang dengan jumlah 50%. Saran bagi masyarakat yang bersepeda untuk lebih memperhatikan protokol kesehatan pada saat melakukan olahraga bersepeda.

Abstract
This research is a quantitative descriptive study. The purpose of this study is to find out empirically about public interest and interest in cycling in the city of Semarang. The population of all people who participate in cycling activities in the city of Semarang is sampling using a random sampling technique. The test instrument uses a questionnaire or questionnaire.The results regarding the enthusiasm and interest of the community in cycling in the city of Semarang which show the very high category are 10 people or 10% of the total number, for the high category there are 11 people or 11%, for the medium category there are 50 people or 50%. while the results for the low category are 26 people or 26% and the very low category are 3 people or 3%. These results can be interpreted that the enthusiasm and interest of the community in cycling in the city of Semarang can be said to be moderate with a total of 50%.The conclusions from the research regarding the enthusiasm and interest of the community in cycling in the city of Semarang can be said to be moderate with the amount of 50%. Suggestions for people who cycle to pay more attention to health protocols when doing cycling sport.