bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterization of orofacial features in sclerodermatous chronic graft‐versus‐host disease
Authors: Bajonaid Amal , Guntaka Praveen Kumar , Harper Matthew , Cutler Corey , Duncan Christine , Villa Alessandro , Sroussi Hervé Y. , Woo Sook‐Bin , Treister Nathaniel S. 
Published: March 2024

AbstractBackgroundChronic graft‐versus‐host disease (cGVHD) is a leading cause of morbidity and mortality following allogeneic hematopoietic cell transplantation (alloHCT). The sclerodermatous form of cGVHD can be particularly debilitating; however, orofacial sclerodermatous involvement remains poorly described.ObjectiveTo characterize orofacial features of sclerodermatous cGVHD in a single center cohort of patients who underwent alloHCT.Study DesignRetrospective data were collected from electronic medical records and analyzed descriptively.ResultsThere were 39 patients who received alloHCT between 1993 and 2017 and developed orofacial sclerodermatous cGVHD. Concomitant cutaneous sclerodermatous cGVHD was common (n = 20, 51%). Orofacial sclerodermatous cGVHD features included fibrous bands of the buccal mucosa (n = 23, 59%), limited mouth opening (n = 19, 54%), perioral fibrosis (n = 8, 21%), and focal gingival recession (n = 4, 10%). Oral mucosal fibrosis was observed at the site of active or resolved chronic lichenoid inflammation in 30 patients, with all but two also presenting with a history of ulcerations. Management included jaw stretching exercises (n = 10; 6 stable/improved), surgery (n = 3; 2 improved), and intralesional corticosteroid injections (n = 2; 2 improved).ConclusionsOrofacial involvement with sclerodermatous cGVHD can present with multiple manifestations including fibrous banding, limited mouth opening, perioral fibrosis, and focal gingival recession. Surgical and non‐surgical management strategies may improve clinical function and reduce morbidity.
Investigating the role of salivary Interleukin‐40 levels in diagnosing periodontal diseases
Authors: Babun Fatma Köksel , Kayar Nezahat Arzu , Hatipoğlu Mükerrem 
Published: March 2024

AbstractBackgroundThe present study aimed to analyze IL‐40, IL‐1β, and MMP‐8 levels in periodontitis as well as gingivitis and periodontal health, and to explore potential correlations between these biomarkers and standard clinical parameters.Materials and methodsWe collected saliva samples from 120 systemically healthy, non‐smoking individuals aged between 18 and 63 years. These individuals were divided into three groups: healthy controls [S], gingivitis [G], and stage III grade B periodontitis [P]. IL‐40, IL‐1β, and MMP‐8 levels in saliva samples were analyzed by ELISA.ResultsWe observed significantly elevated salivary IL‐40 levels in the G group compared to the S group (p = 0.003). We found significantly higher salivary IL‐1β levels in the P group compared to both the S and G groups (p = 0.000). Salivary MMP‐8 levels were significantly higher in the P group than in the S group (p = 0.016).ConclusionOur study suggests that IL‐40 and IL‐1β may serve as effective salivary biomarkers for diagnosing gingivitis, while MMP‐8 and IL‐1β may be effective for distinguishing periodontitis. Based on our study's findings, it can be stated that IL‐40 may serve as a new and effective biomarker for distinguishing individuals with gingivitis from healthy ones.
Identification and functional study of a novel variant of PAX9 causing tooth agenesis
Authors: Lei Rong , Qiu Xili , Han Ying , Li Fenghua , Dong Xin , Pei Saimin , Zeng Ting , Ge Minmin , Hu Zhengmao , Tian Qi , Peng Ling , Huang Junhui 
Published: March 2024

AbstractObjectivesTo search for pathogenic gene of a family with non‐syndromic tooth agenesis, and explore the possible pathogenesis.Materials and MethodsA Chinese family with non‐syndromic tooth agenesis was recruited and screened for the pathogenic variants by whole exome sequencing technology and co‐segregation analysis. The subcellular localization of wild‐type and mutant protein was detected by immunofluorescence assay. Cycloheximide chase assay was performed to examine the difference in degradation rate between mutant protein and wild‐type one. Dual‐luciferase reporter assays were conducted to explore the alterations of mutant protein in the regulation of downstream target genes.ResultsA novel missense variant of PAX9 (c.296C>A:p.A99D) was found in this family. Bioinformatics software showed β‐return and the random coil were shortened in the p.A99D. The variant did not affect the subcellular localization of PAX9, but the degradation rate of p.A99D was accelerated (p < 0.05). p.A99D inhibited the activation of downstream target gene BMP4 (p < 0.05).ConclusionsThis novel variant expands the pathogenic gene spectrum. The variant impaired the protein structure, accelerated the degradation of protein, and inhibited the activation of the downstream target gene BMP4, an upstream molecule in the TGF‐β/BMP pathway, which may contribute to tooth agenesis in this family.
Regulation of carbohydrate metabolism during anther development in a thermo‐sensitive genic male‐sterile wheat line
Authors: Gao Huanting , Li Dongxiao , Hu Haiyan , Zhou Feng , Yu Yongang , Wei Qichao , Liu Qili , Liu Mingjiu , Hu Ping , Chen Eryong , Song Puwen , Su Xiaojia , Guan Yuanyuan , Qiao Mei , Ru Zhengang , Li Chengwei 
Published: March 2024

AbstractBainong sterility (BNS) is a thermo‐sensitive genic male sterile wheat line, characterised by anther fertility transformation in response to low temperature (LT) stress during meiosis, the failure of vacuole decomposition and the absence of starch accumulation in sterile bicellular pollen. Our study demonstrates that the late microspore (LM) stage marks the transition from the anther growth to anther maturation phase, characterised by the changes in anther structure, carbohydrate metabolism and the main transport pathway of sucrose (Suc). Fructan is a main storage polysaccharide in wheat anther, and its synthesis and remobilisation are crucial for anther development. Moreover, the process of pollen amylogenesis and the fate of the large vacuole in pollen are closely intertwined with fructan synthesis and remobilisation. LT disrupts the normal physiological metabolism of BNS anthers during meiosis, particularly affecting carbohydrate metabolism, thus determining the fate of male gametophytes and pollen abortion. Disruption of fructan synthesis and remobilisation regulation serves as a decisive event that results in anther abortion. Sterile pollen exhibits common traits of pollen starvation and impaired starch accumulation due to the inhibition of apoplastic transport starting from the LM stage, which is regulated by cell wall invertase TaIVR1 and Suc transporter TaSUT1.
Unraveling root and rhizosphere traits in temperate maize landraces and modern cultivars: Implications for soil resource acquisition and drought adaptation
Authors: Wild Andreas J. , Steiner Franziska A. , Kiene Marvin , Tyborski Nicolas , Tung Shu‐Yin , Koehler Tina , Carminati Andrea , Eder Barbara , Groth Jennifer , Vahl Wouter K. , Wolfrum Sebastian , Lueders Tillmann , Laforsch Christian , Mueller Carsten W. , Vidal Alix , Pausch Johanna 
Published: March 2024

AbstractA holistic understanding of plant strategies to acquire soil resources is pivotal in achieving sustainable food security. However, we lack knowledge about variety‐specific root and rhizosphere traits for resource acquisition, their plasticity and adaptation to drought. We conducted a greenhouse experiment to phenotype root and rhizosphere traits (mean root diameter [Root D], specific root length [SRL], root tissue density, root nitrogen content, specific rhizosheath mass [SRM], arbuscular mycorrhizal fungi [AMF] colonization) of 16 landraces and 22 modern cultivars of temperate maize (Zea mays L.). Our results demonstrate that landraces and modern cultivars diverge in their root and rhizosphere traits. Although landraces follow a ‘do‐it‐yourself’ strategy with high SRLs, modern cultivars exhibit an ‘outsourcing’ strategy with increased mean Root Ds and a tendency towards increased root colonization by AMF. We further identified that SRM indicates an ‘outsourcing’ strategy. Additionally, landraces were more drought‐responsive compared to modern cultivars based on multitrait response indices. We suggest that breeding leads to distinct resource acquisition strategies between temperate maize varieties. Future breeding efforts should increasingly target root and rhizosphere economics, with SRM serving as a valuable proxy for identifying varieties employing an outsourcing resource acquisition strategy.
Relatedness, Complexity and Regional Diversification in the European Union: The Role of Co‐inventor Networks
Authors: Qiao Yibo , Wu Di 
Published: March 2024

AbstractWe investigate the role of both internal and external co‐inventor networks in regional diversification. The impact of co‐inventor networks on regional technological diversification is tested for a data set containing 1,495,699 patents in 643 technologies in 290 European regions at the NUTS‐2 level, between 1987 and 2016. Our results show that both internal co‐inventor network connectivity and external co‐inventor network linkages could benefit regional technology entry and prevent regional technology exit. However, too inwardly oriented or outwardly connected co‐inventor networks would hamper patent production. Regarding regional diversification, we find that both internal and external co‐inventor networks could facilitate the entry of related technologies and restrain the exit of complex technologies. This paper contributes to the literature by initiating the integration of the complexity dimension into analysing the role of co‐inventor networks in regional diversification. This research bears significant policy implications for the advancement of Smart Specialization Strategy in the European Union.
High Gain Compact Antenna-in-Package Solution Using Like Mushroom Electromagnetic Band Gap for Industrial, Scientific, and Medical Band
Authors: Hajlaoui El Amjed , Almohaimeed Ziyad M. , Almohaimeed Abdullah , Abdulkawi Wazie 
Published: March 2024

Abstract
A single-feed circularly polarized antenna with electromagnetic band gap (EBG) has been developed for the Industrial, Scientific, and Medical (ISM) bands. The proposed antenna features a square patch with eight slits on each side and corner, along with a cross-slot in the middle. To prevent surface wave excitation caused by the patch antenna's thick substrate, new grounded like-mushroom EBG structures will surround the antenna. The frequency band gap characteristics of the EBG unit cells have been optimized at 5.8 GHz. A row of EBGs squares is 4.73 mm (0.063λo) away from the antenna square patch and surrounds it on all four sides. The proposed mushroom-like structure design improves the antenna's directivity by 43.31%, gain by 32.93%, reflection coefficient by 93%, and radiation efficiency by 35.22%. This topology enables a wide variety of wireless communications applications. Computer simulation technologies (CSTs) were used to generate simulation figures for the proposed antenna, operating at 5.8 GHz. Furthermore, the new Like-Mushroom EBG antenna simulation, experimental results, and other reported works confirm that our approach meets the studied objectives regarding polarization purity, radiation efficiency, high directivity, and gain.
Nanofluids and Nanocomposite Membranes for Enhanced CO2 Capture: A Comprehensive Review
Authors: Aletan Dirar , Shirif Ezeddin , Jacob Muthu SD 
Published: March 2024

Abstract
The increasing concentration of greenhouse gasses in Earth's atmosphere is a critical concern, of which 75% of carbon dioxide (CO2) emissions are from the combustion of fossil fuels. This rapid increase in emissions led to irredeemable damages to ecosystems, such as climate change and acid rain. As a result, industries and academia have focused on developing innovative and cost-effective technologies for CO2 capture and storage (CCS). Physical/chemical absorption using amine and membrane-based technologies is generally used in CCS systems. However, the inherent technical and cost-effective limitations of these techniques directed their attention toward applying nanotechnologies for CCS systems. Here, the researchers have focused on infusing nanoparticles (NPs) into existing CCS technologies. The NPs could either be suspended in a base fluid to create nanofluids (NFs) or infused with membrane base materials to create nanocomposite membranes for enhanced carbon capture capabilities. This review paper investigates the manufacturing methods, characterization techniques, and various mechanisms to analyze the impact of nanoparticles-infused nanofluids and nanocomposite membranes for CO2 capture. Finally, the paper summarizes the factors associated with the two technologies and then outlines the drawbacks and benefits of incorporating NPs for CCS applications.
One-Way Fluid–Structure Interaction Simulation of the Added Damping of T(0,1) Modes of Two Partially Overlapped Identical Plates in Still Water
Authors: Ming Zhang , Qing-Guang Chen , Jun Li 
Published: March 2024

Abstract
Structures with a partially overlapped status in water can be seen in some engineering applications, and the fluid-structure coupling vibration behavior of two partially overlapped identical plates has been studied previously through the experimental method. In this study, the added damping of the T(0,1) modes of two submerged partially overlapped plates is numerically investigated through the one-way fluid-structure interaction (FSI) method. The relevant numerical settings, like the mesh size, calculated periods, time-step size, and vibration amplitude, were tested first. Then, the numerical results were compared with experimental results, and good agreements were found. Finally, numerical results were analyzed. The vibration status of two plates in the joint abutting area or the overlapped area has an important influence on the added mass variation. When the added mass is higher, the phase difference between modal force and vibration displacement is also greater, which is the main reason for the higher added damping. The relationship between the phase difference and the frequency in water can be approximately fitted to a straight line, which can probably be used to predict the added damping variations caused by fluid boundary changes of submerged structures.
A Numerical Investigation of Mixed Thermal Elastohydrodynamic Lubrication in Tilting-Pad Journal Bearing
Authors: Luo Qing , Dong Qingbing , Zhao Bin , Yang Haishi , Wei Jing , Zhao Bo 
Published: March 2024

Abstract
The tilting-pad journal bearing in the cooling system of the nuclear power plant is equipped below the ground and vertically positioned to accomplish its function for water transfer. Usually, the loading conditions are relatively stable since the required water volume almost remains the same level during the operation, but the loading direction cannot be known in advance. Furthermore, the bearing is designed with several separate pads, which allows the bearing to support the loading flexibly. The safety application of nuclear energy requires the bearing to have a reliable ability to maintain the rotating motion of gear sets. This study develops a numerical model to simulate the mixed thermo-elastohydrodynamic lubrication for the tilting-pad journal bearing in the nuclear plant. The elastic and thermal fields are properly determined, and the induced displacement is taken into account for an accurate description of film thickness. The asperity contact due to misaligned journal is well evaluated in the local area where the lubrication film cannot separate the surfaces. A parametric study is undertaken in detail to reveal the aspects that influence bearing lubrication. The conclusions potentially provide fundamentals for further lubrication optimization of the bearing system.
Tartrate fermentation with H
2
production by a new member of
Sporomusaceae
enriched from rice paddy soil
Authors: Pereira-Mora Luciana , Guerrero Leandro D. , Erijman Leonardo , Fernández-Scavino Ana 
Published: March 2024

ABSTRACT

In rice paddies, soil and plant-derived organic matter are degraded anaerobically to methane (CH
4
), a powerful greenhouse gas. The highest rate of methane emission occurs during the reproductive stage of the plant when mostly dicarboxylic acids are exudated by the roots. The emission of methane at this stage depends largely on the cooperative interaction between dicarboxylic acid-fermenting bacteria and methanogenic archaea in the rhizosphere. The fermentation of tartrate, one of the major acids exudated, has been scarcely explored in rice paddy soils. In this work, we characterized an anaerobic consortium from rice paddy soil composed of four bacterial strains, whose principal member (LT8) can ferment tartrate, producing H
2
and acetate. Tartrate fermentation was accelerated by co-inoculation with a hydrogenotrophic methanogen. The assembled genome of LT8 possesses a Na
+
-dependent oxaloacetate decarboxylase and shows that this bacterium likely invests part of the H
2
produced to reduce NAD(P)
+
to assimilate C from tartrate. The phylogenetic analysis of the 16S rRNA gene, the genome-based classification as well as the average amino acid identity (AAI) indicated that LT8 belongs to a new genus within the
Sporomusaceae
family. LT8 shares a few common features with its closest relatives, for which tartrate degradation has not been described. LT8 is limited to a few environments but is more common in rice paddy soils, where it might contribute to methane emissions from root exudates.

IMPORTANCE
This is the first report of the metabolic characterization of a new anaerobic bacterium able to degrade tartrate, a compound frequently associated with plants, but rare as a microbial metabolite. Tartrate fermentation by this bacterium can be coupled to methanogenesis in the rice rhizosphere where tartrate is mainly produced at the reproductive stage of the plant, when the maximum methane rate emission occurs. The interaction between secondary fermentative bacteria, such as LT8, and methanogens could represent a fundamental step in exploring mitigation strategies for methane emissions from rice fields. Possible strategies could include controlling the activity of these secondary fermentative bacteria or selecting plants whose exudates are more difficult to ferment.
Association of phenotypic frailty and hand grip strength with telomere length in SLE
Authors: Lieber Sarah B , Lipschultz Robyn A , Syed Shahrez , Rajan Mangala , Venkatraman Sara , Lin Myriam , Reid M Carrington , Lue Neal F , Mandl Lisa A 
Published: March 2024

ObjectiveFrailty and objective hand grip strength (one of the components of the frailty phenotype) are both risk factors for worse health outcomes in SLE. Whether telomere length, an established cellular senescence marker, is a biologic correlate of the frailty phenotype and hand grip strength in patients with SLE is not clear. First, we aimed to evaluate differences in telomere length between frail and non-frail women with SLE and then assessed whether frailty or hand grip strength is differentially associated with telomere length after adjusting for relevant confounders.MethodsWomen ≥18 years of age with validated SLE enrolled at a single medical centre. Fried frailty status (which includes hand grip strength), clinical characteristics and telomere length were assessed cross-sectionally. Differences between frail and non-frail participants were evaluated using Fisher’s exact or Wilcoxon rank-sum tests. The associations between frailty and hand grip strength and telomere length were determined using linear regression.ResultsOf the 150 enrolled participants, 131 had sufficient data for determination of frailty classification; 26% were frail with a median age of 45 years. There was a non-significant trend towards shorter telomere length in frail versus non-frail participants (p=0.07). Hand grip strength was significantly associated with telomere length (beta coefficient 0.02, 95% CI 0.004, 0.04), including after adjustment for age, SLE disease activity and organ damage, and comorbidity (beta coefficient 0.02, 95% CI 0.002, 0.04).ConclusionsDecreased hand grip strength, but not frailty, was independently associated with shortened telomere length in a cohort of non-elderly women with SLE. Frailty in this middle-aged cohort may be multifactorial rather than strictly a manifestation of accelerated ageing.
The success of computational material design for sustainable energy catalysis
Authors: Siahrostami Samira , Murray Nicholas 
Published: March 2024

Computational material design (CMD) employs quantum mechanical simulations, density functional theory, and machine learning techniques to correlate electronic structural attributes with physical and chemical properties of materials. Over the last decade, CMD has proven to be critical to the advancement of materials science and a variety of engineering fields. This contribution provides an overview of CMD’s success in driving materials discovery for catalysis in the context of sustainable energy applications. Specifically, we discuss how CMD has enabled the development of catalysts for three electrochemical processes that are critical to sustainable energy applications, oxygen reduction reactions, water oxidation reactions, and CO2 reduction reactions. We illustrate how CMD provides a powerful and efficient method for understanding underlying reaction mechanisms as well as predicting and optimizing catalyst properties. Furthermore, we demonstrate how this strategic approach has enabled researchers to effectively navigate the vast chemical space of potential catalysts and rapidly identify novel materials possessing desirable electronic structures and catalytic activity.
Local oscillator port integrated resonator for Rydberg atom-based electric field measurement enhancement
Authors: Wu Bo , Liao Dunwei , Ding Zhenke , Yang Kai , Liu Yi , Sang Di , An Qiang , Fu Yunqi 
Published: March 2024

AbstractRydberg atom-based superheterodyne with additional local oscillator (LO) signal is a novel approach to detect electric field with high measured sensitivity. However, the LO signal is often supplied to the atomic vapor cell by free-space illumination, which lacks mobility and integration for practical applications. Here, we present a LO port integrated split-ring resonator for realizing high sensitivity-enhanced electric field measurements. The LO signal is sent directly to the resonator through a parallel-plate waveguide, which is shown to achieve a sensitivity enhancement of 32 dB. The integrated resonator has an electrical size of 0.088λ and the feed port S11 reaches −38.2 dB.