bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Revised Hurricane Pressure–Wind Model
Authors: Holland Greg 
Published: February 2008

Abstract
A new technique for relating central pressure and maximum winds in tropical cyclones is presented, together with a method of objectively determining a derivative of the Holland b parameter, bs, which relates directly to surface winds and varies with the pressure drop into the cyclone center, intensification rate, latitude, and translation speed. By allowing this bs parameter to vary, a realistic scatter in maximum winds for a given central pressure is obtained. This provides an improvement over traditional approaches that provide a unique wind for each central pressure. It is further recommended that application of the Dvorak satellite-interpretation technique be changed to enable a direct derivation of central pressure. The pressure–wind model derived here can then provide the maximum wind estimates. The recent North Atlantic data archive is shown to be largely derived from the use of the Dvorak technique, even when hurricane reconnaissance data are available and Dvorak overestimates maximum winds in this region for the more intense hurricanes. Application to the full North Atlantic hurricane archive confirms the findings by Landsea (1993) of a substantial overestimation of maximum winds between 1950 and 1980; the Landsea corrections do not completely remove this bias.
Cu-Fe-U phosphate mineralization of the Hagendorf-Pleystein pegmatite province, Germany: with special reference to laser-ablation inductively-coupled plasma mass spectrometry (LA-ICP-MS) of limonite-cored torbernite
Authors: Dill H. G. , Gerdes A. , Weber B. 
Published: February 2008

AbstractIron played a decisive part when uranyl phosphates (‘yellow U ores’) formed during supergene alteration of the aplitic and pegmatitic rocks of the Hagendorf Pegmatite Province. Three different supergene U mineral successions, referred to in the current study as pathways I to III, were identified. Pathway I began with the release of PO42– by the dissolution of rockbridgeite and ended after shortdistance transport under alkaline reducing or slightly acidic oxidizing conditions in the precipitation of bassetite. Pathway II is an advanced form of pathway I that did not stop with the precipitation of bassetite, but progressed by acidic Cu-bearing meteoric waters under oxidizing conditions up to the torbernite precipitation stage. Minor amounts of Mn or Ca may have led to a deviation from the normal pathway into the stability fields of lehnerite or autunite, respectively, both of which may occur either as solid solution series or in a layered intergrowth with torbernite. Limonite-cored torbernite has been described for the first time and only exists in pathway III. Unlike its counterpart pathways I and II, which appeared at the end of a complex polystage element recycling process of secondary Fe phosphates under fluctuating redox and pH conditions, limonite-cored torbernite resulted from a monostage transformation of primary ‘black Fe-U ore minerals’ under strongly oxidizing conditions and short-distance element transport. These restricted physicochemical conditions caused the immediate stabilization of the Fe-U-P system and by doing so the U-Pb ratios of the black ore progenitor were well preserved in the limoniticc ore. Torbernite was analysed for U, Th and Pb isotopes by laser ablation inductively coupled plasma mass spectrometry techniques. For one domain the data yielded a formation age of 4.55±0.02 Ma, which corresponds to Miocene-Pliocene weathering and geomorphological processes in the study area. A second domain gave a discordia with an upper intercept age of 549±12 Ma, interpreted to represent a thermal event at the Precambrian-Cambrian boundary. Ferrocolumbite is found exclusively in the mineralization of pathway III. Due to the proximity of ferrocolumbite to torbernite, limonite-cored torbernite probably inherited the 549 Ma age from ferrocolumbite during supergene alteration.
Mineral chemistry of monazite from the black sand deposits, northern Sinai, Egypt: a provenance perspective
Authors: Dawood Y. H. , Abd El-Naby H. H. 
Published: February 2008

AbstractElectron microprobe analysis (EMPA) and microscopic investigations were performed on monazite grains from the black sand deposits of northern Sinai beach. Electron microprobe backscattered electron images, X-ray mapping and wavelength dispersive spectroscopy line scans showed some grains with sector zoning and others with thorite inclusions. Based on the EMPA data, the studied monazite is grouped into monazite-(Ce) and Th-rich monazite. Monazite-(Ce) is enriched in REE and P, whereas Th-rich monazite is enriched in Th, U, Ca, Y, Si and Fe. The compositional variations of monazite are governed by the substitution of REE by Th, U, Ca and Y. The monazite grains show enriched chondrite-normalized REE patterns represented mainly by LREE and only Gd from the HREE. These patterns demonstrate negative Nd and Euanomalies. The floods associated with the pluvial periods which prevailed in Egypt during the Pleistocene, were able to erode the source rocks and liberate heavy minerals including monazite. The mineral grains were transported through several wadis and tributaries to the main channel of the River Nile. At the confluence sites, these heavy minerals were mixed with Ethiopian and central African heavy mineral assemblages. The grains continued to move together downriver until being deposited in their current locations. The analytical results suggest that pegmatites and granites of the Eastern Desert are the most likely source of the monazite. However, due to the large area of the Nile watershed, other undiscovered sources are possible.
Geochemical behaviour and mineralogical transformations during spontaneous combustion of a coal waste pile in Oslavany, Czech Republic
Authors: Dokoupilová P. , Sracek O. , Losos Z. 
Published: February 2008

AbstractGeochemical processes and mineralogical transformations in the spontaneously combusting coal waste pile of the Kukla mine in Oslavany, Czech Republic, were investigated. The aims of the study were: (1) the characterization of secondary minerals; and (2) determination of processes which influence the mobility of elements in the pile. The pile burned from the late 19th century until the 1990s and has acquired a zoned nature, with original black material in the core of the pile, red material produced by burning close to the pile slopes and grey and white efflorescent salts precipitated on the pile top and slopes. Several mineral assemblages have been identified including (1) primary minerals in the black material including bituminous coal to anthracite, micas, pyrite and goethite; (2) hematite, spinels and corundum in the red materialproduced by pyrometamorphism; and (3) hydrated sulphates of magnesium including hexahydrite, konyaite and picromerite in efflorescent precipitates on the slopes of the pile. A conceptual model of geochemical processes in the pile includes seasonal changes with mineral dissolution during the wet season and precipitation of efflorescent salt minerals during the dry season. Formation of secondary minerals such as hematite, which is resistant to weathering and immobilizes hydrolysable Fe, may have a positive environmental impact in the long term.
Reduced incidence of ischemic stroke in patients with severe factor XI deficiency
Authors: Salomon Ophira , Steinberg David M. , Koren-Morag Nira , Tanne David , Seligsohn Uri 
Published: February 2008

AbstractInherited disorders of hemostasis are natural models for investigating mechanisms of thrombosis and development of antithrombotic therapy. Because mice with total factor XI deficiency are protected against ischemic stroke and do not manifest excessive bleeding, we investigated the incidence of ischemic stroke in patients with severe inherited factor XI deficiency. Incidence of ischemic stroke in 115 patients aged 45 years or more with severe factor XI deficiency (activity less than 15 U/dL) was compared with incidence in the Israeli population as estimated from a stroke survey of 1528 patients. Adjustment for major risk factors of stroke (hypertension, diabetes mellitus, hypercholesterolemia, current smoking) was based on comparison of their prevalence in the stroke survey to an Israeli health survey of 9509 subjects. Incidence of myocardial infarction in the factor XI cohort was also recorded. After adjustment for the 4 major risk factors of ischemic stroke, the expected incidence of ischemic stroke was 8.56 compared with one observed (P = .003). The reduced 1:115 incidence of ischemic stroke contrasted with a 19:115 incidence of myocardial infarction, similar to the expected incidence. Thus, severe factor XI deficiency probably is protective against ischemic stroke but not against acute myocardial infarction.
Clonally related follicular lymphomas and histiocytic/dendritic cell sarcomas: evidence for transdifferentiation of the follicular lymphoma clone
Authors: Feldman Andrew L. , Arber Daniel A. , Pittaluga Stefania , Martinez Antonio , Burke Jerome S. , Raffeld Mark , Camos Mireia , Warnke Roger , Jaffe Elaine S. 
Published: February 2008

AbstractRare cases of histiocytic and dendritic cell (H/DC) neoplasms have been reported in patients with follicular lymphoma (FL), but the biologic relationship between the 2 neoplasms is unknown. We studied 8 patients with both FL and H/DC neoplasms using immunohistochemistry, fluorescence in situ hybridization (FISH) for t(14;18), and polymerase chain reaction (PCR)/sequencing of BCL2 and IGH rearrangements. There were 5 men and 3 women (median age, 59 years). All cases of FL were positive for t(14;18). The H/DC tumors included 7 histiocytic sarcomas, 5 of which showed evidence of dendritic differentiation, and 1 interdigitating cell sarcoma. Five H/DC tumors were metachronous, following FL by 2 months to 12 years; tumors were synchronous in 3. All 8 H/DC tumors showed presence of the t(14;18) either by FISH, or in 2 cases by PCR with the major breakpoint region (MBR) probe. PCR and sequencing identified identical IGH gene rearrangements or BCL2 gene breakpoints in all patients tested. All H/DC tumors lacked PAX5, and up-regulation of CEBPβ and PU.1 was seen in all cases tested. These results provide evidence for a common clonal origin of FL and H/DC neoplasms when occurring in the same patient, and suggest that lineage plasticity may occur in mature lymphoid neoplasms.
High-throughput bioinformatics with the Cyrille2 pipeline system
Authors: Fiers Mark WEJ , van der Burgt Ate , Datema Erwin , de Groot Joost CW , van Ham Roeland CHJ 
Published: February 2008

Abstract

Background
Modern omics research involves the application of high-throughput technologies that generate vast volumes of data. These data need to be pre-processed, analyzed and integrated with existing knowledge through the use of diverse sets of software tools, models and databases. The analyses are often interdependent and chained together to form complex workflows or pipelines. Given the volume of the data used and the multitude of computational resources available, specialized pipeline software is required to make high-throughput analysis of large-scale omics datasets feasible.

Results
We have developed a generic pipeline system called Cyrille2. The system is modular in design and consists of three functionally distinct parts: 1) a web based, graphical user interface (GUI) that enables a pipeline operator to manage the system; 2) the Scheduler, which forms the functional core of the system and which tracks what data enters the system and determines what jobs must be scheduled for execution, and; 3) the Executor, which searches for scheduled jobs and executes these on a compute cluster.

Conclusion
The Cyrille2 system is an extensible, modular system, implementing the stated requirements. Cyrille2 enables easy creation and execution of high throughput, flexible bioinformatics pipelines.
Rapid bursts of androgen-binding protein (Abp) gene duplication occurred independently in diverse mammals
Authors: Laukaitis Christina M , Heger Andreas , Blakley Tyler D , Munclinger Pavel , Ponting Chris P , Karn Robert C 
Published: February 2008

Abstract

Background
The draft mouse (Mus musculus) genome sequence revealed an unexpected proliferation of gene duplicates encoding a family of secretoglobin proteins including the androgen-binding protein (ABP) α, β and γ subunits. Further investigation of 14 α-like (Abpa) and 13 β- or γ-like (Abpbg) undisrupted gene sequences revealed a rich diversity of developmental stage-, sex- and tissue-specific expression. Despite these studies, our understanding of the evolution of this gene family remains incomplete. Questions arise from imperfections in the initial mouse genome assembly and a dearth of information about the gene family structure in other rodents and mammals.

Results
Here, we interrogate the latest 'finished' mouse (Mus musculus) genome sequence assembly to show that the Abp gene repertoire is, in fact, twice as large as reported previously, with 30 Abpa and 34 Abpbg genes and pseudogenes. All of these have arisen since the last common ancestor with rat (Rattus norvegicus). We then demonstrate, by sequencing homologs from species within the Mus genus, that this burst of gene duplication occurred very recently, within the past seven million years. Finally, we survey Abp orthologs in genomes from across the mammalian clade and show that bursts of Abp gene duplications are not specific to the murid rodents; they also occurred recently in the lagomorph (rabbit, Oryctolagus cuniculus) and ruminant (cattle, Bos taurus) lineages, although not in other mammalian taxa.

Conclusion
We conclude that Abp genes have undergone repeated bursts of gene duplication and adaptive sequence diversification driven by these genes' participation in chemosensation and/or sexual identification.
Mobile phone radiation might alter protein expression in human skin
Authors: Karinen Anu , Heinävaara Sirpa , Nylund Reetta , Leszczynski Dariusz 
Published: February 2008

Abstract

Background
Earlier we have shown that the mobile phone radiation (radiofrequency modulated electromagnetic fields; RF-EMF) alters protein expression in human endothelial cell line. This does not mean that similar response will take place in human body exposed to this radiation. Therefore, in this pilot human volunteer study, using proteomics approach, we have examined whether a local exposure of human skin to RF-EMF will cause changes in protein expression in living people.

Results
Small area of forearm's skin in 10 female volunteers was exposed to RF-EMF (specific absorption rate SAR = 1.3 W/kg) and punch biopsies were collected from exposed and non-exposed areas of skin. Proteins extracted from biopsies were separated using 2-DE and protein expression changes were analyzed using PDQuest software. Analysis has identified 8 proteins that were statistically significantly affected (Anova and Wilcoxon tests). Two of the proteins were present in all 10 volunteers. This suggests that protein expression in human skin might be affected by the exposure to RF-EMF. The number of affected proteins was similar to the number of affected proteins observed in our earlier in vitro studies.

Conclusion
This is the first study showing that molecular level changes might take place in human volunteers in response to exposure to RF-EMF. Our study confirms that proteomics screening approach can identify protein targets of RF-EMF in human volunteers.
Adjuvant interferon gamma in patients with pulmonary atypical Mycobacteriosis: A randomized, double-blind, placebo-controlled study
Authors: Milanés-Virelles María T , García-García Idrian , Santos-Herrera Yamilet , Valdés-Quintana Magalys , Valenzuela-Silva Carmen M , Jiménez-Madrigal Gaspar , Ramos-Gómez Thelvia I , Bello-Rivero Iraldo , Fernández-Olivera Norma , Sánchez-de la Osa Reinaldo B , Rodríguez-Acosta Carmen , González-Méndez Lidia , Martínez-Sánchez Gregorio , López-Saura Pedro A ,   the MACGAM Study Group
Published: February 2008

AbstractBackgroundHigh antibiotic resistance is described in atypical Mycobacteriosis, mainly byMycobacterium aviumcomplex (MAC).MethodsA randomized, double-blind, placebo-controlled clinical trial was carried out in two hospitals to evaluate the effect of interferon (IFN) gamma as immunoadjuvant to chemotherapy on patients with atypical mycobacteria lung disease. Patients received placebo or 1 × 106IU recombinant human IFN gamma intramuscularly, daily for one month and then three times per week up to 6 months as adjuvant to daily oral azithromycin, ciprofloxacin, ethambutol and rifampin. Sputum samples collection for direct smear observation and culture as well as clinical and thorax radiography assessments were done during treatment and one year after. Cytokines and oxidative stress determinations were carried out in peripheral blood before and after treatment.ResultsEighteen patients were included in the IFN group and 14 received placebo. Groups were homogeneous at entry; average age was 60 years, 75% men, 84% white; MAC infection prevailed (94%). At the end of treatment, 72% of patients treated with IFN gamma were evaluated as complete responders, but only 36% in the placebo group. The difference was maintained during follow-up. A more rapid complete response was obtained in the IFN group (5 months before), with a significantly earlier improvement in respiratory symptoms and pulmonary lesions reduction. Disease-related deaths were 35.7% of the patients in the placebo group and only 11.1% in the IFN group. Three patients in the IFN group normalized their globular sedimentation rate values. Although differences in bacteriology were not significant during the treatment period, some patients in the placebo group converted again to positive during follow-up. Significant increments in serum TGF-beta and advanced oxidation protein products were observed in the placebo group but not among IFN receiving patients. Treatments were well tolerated. Flu-like symptoms predominated in the IFN gamma group. No severe events were recorded.ConclusionThese data suggest that IFN gamma is useful and well tolerated as adjuvant therapy in patients with pulmonary atypical Mycobacteriosis, predominantly MAC. Further wider clinical trials are encouraged.Trial registrationCurrent Controlled Trials ISRCTN70900209.
Which quality of life score is best for glaucoma patients and why?
Authors: Severn Philip , Fraser Scott , Finch Tracy , May Carl 
Published: February 2008

Abstract

Background
The glaucomas are generally asymptomatic diseases until they are very advanced. They affect 2% of the population over 40 years of age and therefore represent a significant public health issue. There have been a number of attempts to develop quality of life scales for the disease. This review discusses the pros and cons of these scales and suggests the best of the current ones for use in a clinical setting.

Methods
Medline, Embase and Google Scholar were searched for relevant articles. No time period was defined and all types of article were included.

Results
11 Quality of Life scores were identified that have been used with glaucoma patients.

Conclusion
There is no generally accepted 'best' Quality of Life instrument for use in glaucoma. Many of the scales are biased towards physical symptoms and do little to address the personal or social factors of the disease. Further work is needed to produce scales that address all these areas as well as being simple to administer in a clinical setting.
Social inequalities in changes in health-related behaviour among Slovak adolescents aged between 15 and 19: A longitudinal study
Authors: Salonna Ferdinand , van Dijk Jitse P , Geckova Andrea Madarasova , Sleskova Maria , Groothoff Johan W , Reijneveld Sijmen A 
Published: February 2008

Abstract

Background
Lower socioeconomic position is generally associated with higher rates of smoking and alcohol consumption and lower levels of physical activity. Health-related behaviour is usually established during late childhood and adolescence. The aim of this study is to explore changes in health-related behaviour in a cohort of adolescents aged between 15 and 19, overall and by socioeconomic position.

Methods
The sample consisted of 844 first-year students (42.8% males, baseline in 1998 – mean age 14.9, follow-up in 2002 – mean age 18.8) from 31 secondary schools located in Kosice, Slovakia. This study focuses on changes in adolescents' smoking, alcohol use, experience with marijuana and lack of physical exercise with regard to their socioeconomic position. Four indicators of socioeconomic position were used – adolescents' current education level and employment status, and the highest education level and highest occupational status of their parents. We first made cross tabulations of HRB with these four indicators, using McNemar's test to assess differences. Next, we used logistic regression to assess adjusted associations, using likelihood ratio tests to assess statistical significance.

Results
Statistically significant increases were found in all health-related behaviours. Among males, the most obvious socioeconomic gradient was found in smoking, both at age 15 and at 19. Variations in socioeconomic differences in health-related behaviour were more apparent among females. Although at age 15, almost no socioeconomic differences in health-related behaviour were found, at age 19 differences were found for almost all socioeconomic indicators. Among males, only traditional socioeconomic gradients were found (the lower the socioeconomic position, the higher the prevalence of potentially harmful health-related behaviour), while among females reverse socioeconomic gradients were also found.

Conclusion
We confirmed an increase in unhealthy health-related behaviour during adolescence. This increase was related to socioeconomic position, and was more apparent in females.
Seeing is believing: an educational outreach activity on disinfection practices
Authors: Mercure Sarah-Amelie , Tetu Isabelle , Lamonde Steeve , Cote Francoise ,   Guides de rue working group
Published: February 2008

Abstract

Background
Skin and soft-tissue infections are very common among persons who inject drugs. They occur when microbes pass under the protective layer of the skin and proliferate. This happens when harm reduction recommendations such as skin aseptia before injection and sterile injection equipment usage are not properly followed.

Methods
A group of active drug users involved in a health promotion project as peer educators were asked about their formation needs. To address their inquiries concerning skin and soft-tissue infections, we devised with them a series of workshops touching upon common infections, the microflora, and microbial transmission.

Results
Participants learned to identify common infections and how to properly react in case of an abscess, cellulitis or phlebitis. They saw microscopic objects, found out about the high prevalence of microbes in their environment and on their skin, and could appreciate the efficiency of different washing and disinfection techniques. They visualized how easily microbes can spread from person to person and from contaminated objects to persons.

Conclusion
In the weeks following this activity, some participants demonstrated and reported healthy behavioural changes regarding their own injection practices. Furthermore, they shared their newfound knowledge and began enforcing its application among people they inject drugs with. Most participants greatly appreciated this activity and valued it as being highly efficient and tangible. Note: A French version of this paper is available on the Journal's web site [see Additional file 1].