bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of the p.I148m polymorphism in the <i>PNPLA3</i> gene with the severity of nonalcoholic fatty liver disease in various clinical groups
Authors: Sidorenko D. V. , Nazarov V. D. , Lapin S. V. , Emanuel V. L. , Raikhelson K. L. , Gomonova V. P. 
Published: April 2024

Introduction. Non-alcoholic fatty liver disease in most cases is closely associated with diseases such as obesity and type 2 diabetes mellitus, however, this dependence is not observed in a number of patients. In this case, hereditary factors, such as the p.I148M polymorphism of the PNPLA3 gene, play the greatest role in the prognosis of the course of the disease.The objective of the study was to evaluate the effect of the p.I148M polymorphism of the PNPLA3 gene on the course of NAFLD in subgroups of patients with and without concomitant metabolic pathology.Methods and materials. The study group included 212 patients with NAFLD who underwent p.I148M genotyping of the PNPLA3 gene. The severity of the disease was assessed in the general group (group P) and in subgroups of patients with the absence and presence of obesity (subgroups O– and O+, respectively) and type 2 diabetes mellitus (subgroups D– and D+). The severity of the disease was assessed by the severity of cytolytic syndrome (ALT level), hepatic steatosis and fibrosis (the value of CAP and liver stiffness according to transient elastometry) within clinical subgroups between carriers of different PNPLA3 genotypes.Results. Higher ALT levels were found in homozygous carriers of p.I148M compared with the reference genotype (CC/GG) in the subgroups P, D–, D+ and O– (p=0.012; p=0.012; p=0.028 and 0.042, respectively), as well as when comparing the general group of carriers with reference genotype (CC/CG+GG) in subgroups P and D– (p=0.036 and p=0.015). More severe steatosis was found in homozygous carriers compared to the reference genotype (CC/GG) in group P (p=0.017) and subgroup O– (p=0.019). Higher values of liver stiffness were noted in the modified PNPLA3 genotype when comparing the reference (CC/CG) genotype with heterozygotes in group P (p=0.027) and subgroup D– (p=0.006) and when comparing the reference genotype with the general carrier group (CC/CG+GG) in subgroup D– (p=0.009).Conclusions. The carriage of p.I148M of the PNPLA3 gene in patients without metabolic disorders (obesity, type 2 diabetes mellitus) is associated with the formation of cytolytic syndrome, steatosis and liver fibrosis.
Personalized medical support for young athletes after splenectomy
Authors: Tsetsema N. S. , Uspenskaia Iu. K. , Matveev S. V. 
Published: April 2024

Introduction. The relevance of the problem is determined – an increase in the number of patients who underwent splenectomy, in the absence of currently developed methodological (clinical) recommendations on admission to training and competitive events.The objective was to develop criteria for admission to training and competitive events, to determine the frequency and volume of medical examinations for this category of persons.Methods and materials. The analysis of the sources of domestic and foreign authors on the management of patients after splenectomy was carried out. We collected the detailed life history, disease history, sports history, information about family history for the development of diseases of the cardiovascular system, gastrointestinal tract, hematopoietic organs, analysis of the hospital discharge summary, data evaluation from laboratory and instrumental studies (particularly, ultrasound examination of the abdominal organs), ECG with exercise, exercise tests (Martinet-Kushelevsky) in two athletes who underwent splenectomy due to various reasons (blunt abdominal trauma, the spleen rupture in athlete A. N., 14 years old, microspherocytic hemolytic Minkowski-Choffard anemia complicated by sepsis in athlete N. V., 12 years old). The functional fitness indicators taking into account the sports training stage, the results of medical and pedagogical observations during the training process before and after surgery were assessed.Results. In the clinical blood analysis of athlete A. N., there was a slight leukocytosis (leukocytes- 10.94∙109/l), thrombocytosis (platelets – 669∙109/l), no changes in erythron, erythrocytes- 5.46∙1012/l, hemoglobin – 136 g/l, hematocrit – 42.3 %, neutrophils – 4.53∙109/l, lymphocytes – 5.33∙109l. Leukocyte formula by microscopy was without significant pathological changes. The diagnosis was confirmed as: “Reactive thrombocytosis. Condition after splenectomy”. According to the results of IME, there were no absolute contraindications to training and competitive football activities. The athlete received a medical certificate of admission to training and competitive events. In the clinical blood analysis of athlete N.V., there was: erythrocytes – 5.44∙1012/l, hemoglobin – 163 g/l, hematocrit – 44.4 %, leukocytes – 12.2∙109/l, neutrophils – 3.8∙109/l, lymphocytes – 6.4∙109/l, platelets – 515∙109/l. He was taken to the regular medical check-up of a hematologist with the diagnosis: “Hereditary spherocytosis, hemolysis compensation. Condition after splenectomy”. Due to the absence of absolute contraindications for training and competitive football events, the athlete was issued the medical certificate on admission to training and competitive events.Conclusion. A splenectomy history is not an absolute contraindication to sports. The management of an athlete after splenectomy requires an individual approach, taking into account age, sport and stage of sports training, the presence of chronic diseases and/or changes in physical, instrumental and laboratory studies.
A Russian regional draft commission report on quality control efforts regarding medical examination of conscripts
Authors: Kuzmin S. A. , Grigorieva L. K. 
Published: April 2024

Introduction. In Russian constituents, draft commissions play the leading role in providing medical services to individuals preparing for military service.The objective of the study is to analyze activities of a regional draft commission located in the Orenburg region with a specific focus on quality control during medical examination of conscripts.Methods. The study relied on reports and records of the Military Medical Expertise Center at the Federal Budgetary Institution “Military Commissariat of the Orenburg Region” throughout 2012 to 2021 timespan.Results and analysis. Within the analyzed 10 year’s timespan the number of conscripts in the Orenburg region decreased by 11.6 %. However, the number of individuals fit for military service (categories “A”+”B”) remained relatively unchanged, e.g. 14058 individuals in 2012 and 14837 in 2021 (except years 2013 and 2014 with 12494 and 12880 individuals in this category, respectively). The ratio between the individuals potentially fit for military service to those actually deployed indicates the rate of conscription withdrawal rate. In 2020 the conscription withdrawal rate was at its minimum value of 26.7 %, reaching its maximum value of 38.8 % in 2013. Within the timespan under study, 47500 individuals residing in the region were conscribed for combat deployment. Following medical examination, 1793 (3.8 %) applicants were withdrawn from conscription as unfit for military service. Within the first three months of military service, 29 (0.06 %) military personnel were dismissed from service for health reasons and general disease diagnosis. Some 52.200 individuals were deferred or exempted from the military draft (fitness categories for military service “B”, “G”, “D”), of which 28200 (54.1 %) were called for a medical revision examination. 2536 citizens were recognized as appropriate for military service (suitability categories “A” + “B”), amounting to 10.1 % of the arrived conscripts.Conclusion. Timely medical examinations of individuals upon conscription for military service, as well as medical and recreational activities for conscripts depend on the due and well-coordinated operation of regional conscription commissions. Under the resolution of the President of Russia on efforts to increase the corps of the Armed Forces of the Russian Federation, more extensive resources of potential military culture scripts are required.
Research perspectives outlined in international publications analyzing medical aid and evacuation measures in emergency (armed conflicts)
Authors: Kupriyanov S. A. , Chernikov O. G. , Zhukov A. A. , Pluzhnik M. S. , Nazarov I. V. 
Published: April 2024

Relevance. The statistics of armed conflicts across the world shows no decrease, causing large numbers of casualties. This compels military medicine professionals to intensify the study of accumulated experience regarding medical aid and evacuation support in combat and emergency settings.The objective is to analyze research perspectives outlined in academic papers published in international journals from 2005 to 2022 and dealing with medical aid and evacuation in emergency scenarios (armed conflicts).Methods. The study analyzes 1.496 international research papers dealing with medical aid and evacuation support management in military forces across the world. All the papers are published in peer-reviewed journals and registered in the PubMed database. The VOSviewer program was used for cluster analysis and visualization of keyword co-occurrences.Results and discussion. In the VOSviewer, keywords were assigned across 6 clusters. Cluster 1 included 28.7 % of publications on general issues of military medicine with the total link strength of 26.4 % in the total study sample, followed by cluster 2 on medical aid and evacuation efforts in emergency situations (19.8 % and 18.9 %, respectively), cluster 3 on therapies and evacuation efforts in combat injuries (16.3 % and 18.7 %), cluster 4 on medevac operations (13.7 % and 13.7 %), cluster 5 on medical aid and evacuation efforts in the USA (11.7 % and 12.8 %), and cluster 6 on emergency medical care in armed conflicts (9.8 % and 9.7 %, respectively). The analysis allowed to identify mainstream international research schools that set the trend in medical aid and evacuation amid emergencies (armed conflicts).Conclusion. Bibliometric databases are a universal tool allowing to expand the scope of research and determine the mainstream trends in military medicine for a particular timespan. The studies by international investigators can useful for Russian military medicine professionals, including comparative studies on medical aid and evacuation efficiency in different countries.
El discurso del “arte nacional” en Colombia
Authors: Vargas Arbelaez Maria Isabel 
Published: April 2024

Through the analysis of three different discourses on “national art” this paper argues that the latter has functioned as an underlying discourse and played a constant and significant role in defining much of artistic production in Colombia and the debates around it. Within this framework I examine the tension between modernity and modernization that comes into view, for example, in the controversy that took place during the last century between the modernist proposals of the Bachué group, which were anti-academic and expressionist, and the attempt at modernization promoted by figures like Marta Traba, with her “updating” campaign, and Eugenio Barney with his theory of transculturation. My hypothesis is that this tension reaches a synthesis in the plastic and conceptual work of Antonio Caro, which addressed the national public. The preceding movements find their synthesis and take a qualitative leap in Caro’s interpretation of the life and work of Manuel Quintín Lame.
CHARACTERIZATION OF THE LEVEL OF ANXIETY OF NURSING STAFF DEPENDING ON THE SPECIFICS OF WORKING CONDITIONS
Authors: Kachmarska Marta , Lyubinets Lidiya , Cipora Elzbieta , Shveda Galyna 
Published: April 2024

Military events on the territory of Ukraine have acted as a factor influencing the state of mental health of the population. At the same time, healthcare professionals who provide medical care to the population, including the military, play an important role, which requires an assessment of their psychological state to ensure the proper quality of medical services.
Aim. To compare the levels of sensitivity of nurses depending on the conditions and specifics of work.
Material and Methods. The material was the results of a survey of nurses using the Spielberger questionnaire, which were conducted in a health care facility in Ukraine, where emergency medical care is provided, and in an oncology clinic in Poland from March to June 2023.
Results and Discussion. The survey found that personal sensitivity, as a factor characterizing the individual character trait of a person, was higher among nurses from Ukraine than among Polish nurses. The level of situational sensitivity, which characterizes the emotional state of a person that arises under the influence of the circumstances, was also higher among respondents from Ukraine, which suggests that the sensitivity of emergency medical care workers in Ukraine against the background of military operations in the country has led to an increase in the levels of both personal and situational sensitivity. A survey of respondents, depending on their age, showed that the high level of personal sensitivity among healthcare workers in Ukraine significantly exceeded that of respondents from Poland, and situational sensitivity was higher in younger groups (19-40 years old). The study proved that the average level of personal sensitivity is not a basis for the emergence of a high level of its situational form.
Conclusions. The specificity of the working conditions of the nursing staff of an emergency medical care hospital, combined with military events in the country, contributed to a higher level of personal and situational sensitivity compared to the characteristics of the levels of sensitivity of nursing staff of an oncology hospital outside Ukraine. External circumstances in the society have an important impact on the level of sensitivity of the staff of a medical institution, reinforcing the specifics of their working conditions.
PENERAPAN METODE HAZARD IDENTIFICATION RISK ASSESSMENT AND RISK CONTROL (HIRARC) DALAM MENGANALISIS POTENSI KECELAKAAN KERJA PADA PT. ARKELINDO BARA SEJAHTERA
Authors: Pahmil Hakim Tedi , Kusuma Ningrat Nugraha , Kurnia Yusup 
Published: April 2024

Arkelindo Bara Sejahtera merupakan sebuah produsen briket arang kelapa yang berlokasi di Desa Padamulya, Kecamatan Cihaurbeuti, Kabupaten Ciamis, Prov Jawa Barat. PT. Arkelindo Bara Sejahtera kegiatan operasional memiliki berbagai macam risiko yang dapat menimbulkan kecelakaan kerja, karena melibatkan berbagai macam peralatan kerja, berhubungan langsung dengan pembakaran arang kelapa, dan sikap kerja para pekerja yang kurang memperhatikan keselamatan dan kesehatan kerja (K3).

Dalam upaya mencegah atau mengurangi terjadinya kecelakaan di lingkungan kerja perlu untuk mengetahui bagaimana analisis risiko kecelakaan kerja pada proses produksi di PT. Arkelindo Bara Sejahtera, dan penelitian ini bertujuan untuk menganalisis berapa besar risiko kecelakaan kerja pada proses prosduksi briket arang kelapa. Apabila potensi risko kecelakaan kerja dapat diidentifikasi, dinilai, dan dikontrol, maka angka risiko kecelakaan kerja dapat diminimalisir atau bahkan menjadi tidak ada sama sekali. Identifikasi bahaya, penilaian risiko, dan pengendalian risiko dapat dilakukan dengan metode Hazard Identification Risk assessment And Risk Control (HIRARC). Metode HIRARC bertujuan untuk mengidentifikasi bahaya, menentukan nilai setiap risiko bahaya yang ditemukan dengan menggunakan tabel kriteria likelihood, kriteria consequence dan perhitungan risk matrix.
Berdasarkan hasil identifikasi menunjukan bahwa dalam proses produksi briket arang kelapa di PT. Arkelindo Bara Sejahtera terdapat 8 temuan potensi bahaya diataraya ada 2 risiko rendah, 2 risiko tinggi dan 4 risiko ekstrim. Sedangkan dari penilaian risiko maka didapatkan 25% bahaya dalam kategori risiko rendah, 25% bah aya dalam kategori risiko tinggi dan 50% bahaya dalam kategori ekstrim.
Estratégias de diagnóstico do Transtorno do Espectro Autista na primeira infância
Authors: Lima Priscila Bezerra de , Viana Elizandra Biá , Miléo Izabela Cristina Albarado , Silva Elane Bento da , Matos Wanessa Figueira Nunes de , Silva Suzana Passos , Ribeiro Mirla Rego , Macêdo Caroline Gomes 
Published: April 2024

Objetivo: Identificar as diferentes estratégias de avaliação clínica utilizadas para diagnosticar o Transtorno do Espectro do Autismo na primeira infância. Métodos: Trata-se de uma revisão integrativa com base em artigos em português e inglês disponíveis gratuitamente na íntegra, provenientes das bases de dados Scielo, PubMed e LILACS. A questão norteadora foi: “Quais são as estratégias e protocolos recomendados para a avaliação clínica e diagnóstico do transtorno do espectro autista na primeira infância?”. A pesquisa abrangeu artigos publicados entre janeiro de 2019 e junho de 2023, utilizando os Descritores Transtorno do Espectro Autista; Criança; Diagnóstico Precoce; Estratégias de Saúde; Protocolos Clínicos, com combinações de estratégias de busca usando o operador booleano “AND”. Resultados: A revisão integrativa englobou nove artigos, revelando resultados promissores no diagnóstico do Transtorno do Espectro Autista (TEA). Os estudos utilizaram diferentes protocolos e estratégias de triagem, como o Autism Behavior Checklist (ABC), o Modified Checklist for Autism in Toddlers (M-CHAT) e a Avaliação Comportamental para Crianças com Suspeita de Transtorno do Espectro Autista Revisado (PROTEA-R). Considerações finais: Os estudos analisados são encorajadores quanto ao diagnóstico do TEA. No entanto, evidencia-se a necessidade de mais pesquisas, especialmente no Brasil, onde são utilizadas triagens internacionais adaptadas.
On the concept of investigator discretion in criminal proceedings
Authors: Grigorieva A. E. 
Published: April 2024

The article examines the concept and essential features of the category «investigator’s discretion». The main features of the investigator’s discretion proposed by procedural scientists are analyzed. It is noted that it is a legal category, representing the choice by the investigator of any behavior option. But these options are provided and limited by law and the procedural powers of the investigator. In the author’s opinion, the most significant properties of the investigator’s discretion are highlighted and designated and the concept of this category is formulated.
« Mettre au monde le monde ».. Sur la relation entre sémiotique de la production et production sémiotique
Authors: Valle Andrea 
Published: April 2024

Le concept de production sémiotique admet au moins une double déclinaison. En premier lieu, et historiquement, il concerne la praxis responsable de la réalisation d’objets qui rentrent dans le domaine de la sémiotique. En d’autres termes, c’est en fonction de la reconnaissance du caractère sémiotique du produit que l’on étudie le parcours historique qui en est à l’origine ; parcours qui, en fonction de cette origine, est pour cela même d’intérêt sémiotique, en tant que « production ». Par exemple, il s’agit de partir d’une œuvre et, une fois qu’elle a assumé le statut de « texte », d’y étudier le travail de l’artiste. En deuxième lieu, on entend par « production » un ensemble d’opérations qui président à la construction sémiotique d’un objet. Or, ce dernier ensemble d’opérations devrait recevoir une formalisation sémiotique qui rende compte du processus de production qui préside à l’achèvement de l’état du produit (et qui est déjà entièrement interne à l’ordre du sémiotique). Si le produit dont il est question est le texte-énoncé (et d’ailleurs cela ne pourrait pas être autrement), alors une théorie de la production coïncide pour l’essentiel avec une théorie de l’énonciation – c’est d’ailleurs ce que Greimas et Courtés remarquaient dans le Dictionnaire, à l’entrée « production ». A partir de cette double déclinaison, une duplicité intéressante découle : un même objet-texte peut donner accès à deux théories de la production, l’une à vocation « exogonique » et l’autre à vocation « endogonique ». La première permet la convocation des pratiques de production historiquement attestées (et par là même, l’étude empirique des pratiques elles-mêmes) ; la seconde conduit à la définition formelle du concept de praxis en sémiotique (à travers un travail fondamental sur la praxis énonciative, travail qui est bien loin d’être terminé). Toutefois, ce hiatus constitue aussi la possibilité d’une connexion. La discussion générale sur le concept de « pratique » demande donc un « nouement » : il sera question de garder ensemble pratiques historiques et modèles sémiotiques, afin d’en évaluer les relations possibles. Pour l’instant, et en exploration, on peut vérifier cet ensemble de problèmes à partir de deux exemples relevants. Le premier est le cas de la notation musicale contemporaine et des phénomènes concernés, entre composition, notation et exécution. Le deuxième exemple sera avancé à partir de quelques compositions d’Alighiero Boetti, dans lesquelles la relation entre projet et réalisation semble suivre des parcours analogues à ceux de la notation musicale.
Faire un point
Authors: Beyaert-Geslin Anne 
Published: April 2024

« Faire » un énoncé artistique, c’est toujours, au départ « faire un point », fût-il grain du pigment archaïque, point de la peinture (Kandinsky), point-écran de la vidéo (Kuntzel) ou pixel de l’écran informatique. Ce grain-point qui détermine la genèse du visuel procède de pratiques différentes selon qu’il manifeste une intentionnalité rituelle (Leroi-Gourhan) ou esthétique. Il suggère également des rapports distincts à l’énonciation et plusieurs définitions épistémologiques : le grain est posé ; avec un liant, il devient peinture et se dispose au geste du peintre tandis que le pixel, échangeur entre l’image et le calcul mathématique, se « fait » à l’écran.Qui « fait » ? (quelle instance) et que « fait »-il (poser, tracer, composer à l’écran…) ? On voit aussi que le lien intime qui relie, par-delà les âges, le pigment de la Préhistoire au pixel d’aujourd’hui, sous-tend des modèles génératifs et des régimes sémiotiques distincts (l’alternative représentation/simulation de Couchot). La différence porte de même sur les rapports à la perception, l’effet « pelliculaire » du pixel renouant avec celui du pigment mais s’opposant résolument aux profondeurs de la peinture. Pourtant, en dépit de ces différences, une ressemblance essentielle subsiste qui tient au caractère veridictoire du grain-point. En effet, c’est toujours ce grain-point qui, devenu ligne (Kandinsky) et figure, déclare l’image comme telle, qu’il trahisse sa fiction au travers du flou ou du carré insistant du pixel-art. Par cet effet métadiscursif, il révèle que l’image a été faite et relève bien d’un « faire » poïétique séparé de l’être, quand bien même elle paraît-être. En ce sens, la « vérité » des images tiendrait moins à la collusion du paraître et de l’être que consacre le carré de la véridiction qu’à une déhiscence fondamentale entre l’être et le « faire ».
Pierre Bergounioux et le paysage corrézien
Authors: Marcheix Daniel 
Published: April 2024

Le paysage corrézien évoqué par de nombreux textes « méditatifs » de Pierre Bergounioux est le cadre d’une expérience sensible particulièrement houleuse. L’activité perceptive y est violemment contrariée par l’hostilité désordonnée et l’instabilité d’un espace clos qui impose au personnage-narrateur une présence vide, quasi pathologique, comme si le monde intérieur était contaminé par l’antagonisme généralisé qui affecte le réel. Dans ce désastre esthésique, seuls le rêve et le cogito cartésien permettent de redonner à la perception une intentionnalité, de rendre le sensible intelligible. Ainsi s’esquisse une nouvelle forme d’immanence, attentive aux « fastes du dehors » que s’emploie à magnifier une écriture poétique ancrée dans la matière même.