bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of cervical ultrasound in prediction of preterm labor
Authors: Dhakal Samjhana , Hebbar Shripad 
Published: November 2008

Aim: To compare the difference in the cervical length measured digitally or by transabdominal and transvaginal sonogram examination for prediction of preterm labour Method: This was a prospective randomized, controlled study in the Department of Obstetrics and Gynaecology at TMA Pai Hospital, Udupi from March 2001 to May 2002 where 200 women coming for routine antenatal care were recruited for the study. A total of 168 women were evaluated, out of which 145 were control group and 23 cases of threatened preterm labor formed study group. Results: The mean length of cervix measured by TVS at 20- 24wks of pregnancy was 3.87 cm. There after there was a slight decrease in the length mainly towards term and or 36 wks of pregnancy i.e. 3.27 cm. Cervical length measured on an average 0.8 cm more than TVS(4.9CM versus 3.52 cm) Similarly digital examination of cervix yielded shorter length, compared to TVS measurement (2.86 cm versus 3.5 cm). Conclusion: This study has shown TVS is a simple tool for prediction of preterm labour as decrease in cervical length was observed in women with threatened preterm labor (2.34 cm) and this decrease was statistically significant compared to that of the control (3.7 cm). Key words: Trans abdominal, transvaginal, preterm labour doi:10.3126/njog.v2i2.1450 N. J. Obstet. Gynaecol 2007 Nov-Dec; 2 (2): 20 - 23
Subsequent vaginal delivery in a case reverted by Dobbins operation for acute uterine inversion: A case report
Authors: Rana Ashma , Gurung Geeta , Pariyar Jitendra , Pokharel Sunil , Adhikari Shilu 
Published: November 2008

A woman with a history of laparotomy and corrective abdominal surgery for acute puerperal uterine inversion reverted by division of the inversion ring anteriorly "Dobbins's operation" subsequently was successful to undergo assisted vaginal breech delivery arriving at second stage of labor warranting, manual removal of placenta which was complied with the management of PPH. This case is reported because of the rarity of uterine inversion itself in the first place. Next because of the conception taking place spontaneously after morbid puerperal period and then the pregnancy advancing to term: all the management beginning from correction of uterine inversion to retained placenta being handled in the same facility a rare event too in our set up. Key words: Uterine inversion and subsequent birth, manual removal of the placenta. doi:10.3126/njog.v2i2.1462 N. J. Obstet. Gynaecol 2007 Nov-Dec; 2 (2): 78 - 80
Unavoidable caesarean myomectomy: A case report
Authors: Owolabi Alexander T , Loto Olabisi M , Kuti Oluwafemi , Ehinmitan Richard R , Ibrahim Ayaba Y 
Published: November 2008

Establishment of the feasibility and need to perform myomectomy during caesarean section when fibroid obstruct wound closure with associated hemorrhage has been presented. A case of a primigravida with a huge uterine fibroid located in the lower segment lifting up the uterine cavity leading to persistent transverse lie of the fetus at term is presented. An elective classical caesarean section was performed with difficulty in uterine wound closure and haemorrhage necessitating myomectomy. Haemorrhage was controlled with the use of Foley catheter tourniquet and high dose oxytocin infusion. Literature review was carried out. The mother and baby had satisfactory outcome. To conclude, life threatening situations of myomectomy with caesarean section ought to be, and can be safely performed using tourniquet and high dose oxytocin to reduce haemorrhage. The uterus in the immediate post partum period is better adapted physiologically to control haemorrhage than any other stage of a woman's life. Key Words: Classical caesarean Section, Myomectomy, caesarean-myomectomy, Haemorrhage. doi:10.3126/njog.v2i2.1463 N. J. Obstet. Gynaecol 2007 Nov-Dec; 2 (2): 81 - 83
Birth of second twin 27 hours after the birth of first
Authors: Jha Rani , Verma Sheela 
Published: November 2008

We hereby report a case of retained second twin presenting with vertex which was delivered vaginally after 27hours from the first birth, without any complication in 25 years old G2 P1 L1 A0 detailing that such obstetric events can be smoothly handled. Keywords: retained second twin, both vertex presentation, obstetric complication in twins. doi:10.3126/njog.v2i2.1464 N. J. Obstet. Gynaecol 2007 Nov-Dec; 2 (2): 84 -85
Maternal serum triglyceride at midpregnancy and newborn weight in nondiabetic and normal BMI women
Authors: Sekhavat Leila , Zare Fatemah , Karbasi Sedighah Akhavan 
Published: November 2008

Aim: To determine whether elevated midpregnancy (24 -28 Gestational weeks) maternal serum lipid levels predict the risk of macrosomia in non-diabetic women. Methods: Nondiabetic pregnant women (who had negative diabetic screens) were enrolled. Fasting serum triglyceride, and total cholesterol levels were measured at 24-28 weeks gestation. We tested the association between maternal variables and birth weight by univariable analysis. We also used multiple logistic regression analysis to determine whether maternal hyperlipidemia is a risk factor for having an LGA infant. Results: We enrolled 190 subjects. Among measured maternal lipids, only triglyceride levels correlated with birth weight in univariable analysis (r2 = 0.40, P = .000). Logistic regression analysis showed that fasting maternal hypertriglyceridemia was the significant predictor of macrosomia, independent of maternal weight gain and fasting plasma glucose levels. (Odds ratio 11.2; 95% confidence interval 1.5, 31.2; P = .01). Conclusion: In nondiabetic women, fasting triglyceride levels at midpregnancy correlated positively with newborn weight at term. Keywords: Birth weight, hypertriglyceridemia, nondiabeic pregnant, normal BMI doi:10.3126/njog.v3i1.1434 NJOG 2008 May-June; 3(1): 19 - 23
Comparative study of labour progress and delivery outcome among induced versus spontaneous labour in nulliparous women using modified WHO partograph
Authors: Orji Ernest O , Olabode Taofeek O 
Published: November 2008

Aim: Induced or spontaneous labour has implication on the eventual mode of delivery and neonatal outcome. The objective of this study is to compare the progress and outcome of induced versus spontaneous labour among nulliparous women using the modified WHO partograph. Methods: Comparative study involving nulliparous women in active phase of labour with the cervix at least 4cm dilated. Those whose labours were induced were compared with those on spontaneous labour; both labouring women were monitored using modified WHO partograph. Outcome measures include the mean duration of labour, the eventual mode of delivery and the feto-material outcome. Data were managed using SPSS software. Chi-square t-test and student t-test were used in data analysis. Level of significance was placed at P < 0.05. Results: 136 women were compared in each group. There were no difference in mean age group, gestational age at delivery, cervical dilatation on admission, and the level of head of fifth palpable on admission. More women had spontaneous vaginal delivery among those in spontaneous labour (72.1% versus 64.7%) P=0.0001. There were less caesarean section among those in spontaneous labour (20.6% versus 35.3%). The mean Apgar scores were significantly better among induced labour babies (P=0.0001). While most induced labour cases reached or crossed action line compared to spontaneous labour (33.1% versus 16.9% P=0.002), there were more cases in spontaneous labour moving between alert and action line (27.9% versus 9.6%, P=0.000) Conclusion: Induced labour monitored with modified WHO partograph is comparative to spontaneous labour with no increased adverse feto maternal outcome. Key words: Induced versus spontaneous labour; modified WHO partograph, labour outcome. doi:10.3126/njog.v3i1.1435 NJOG 2008 May-June; 3(1): 24 - 28
Ovulation Induction, Pregnancy and Delivery in a Patient with Partial Hypopituitarism due to Lymphocystic Hypophysitis: A Case Report
Authors: Ezechi OC , Ezeobi PM , Nwokoro CA 
Published: November 2008

Lymphocystic hypophysitis is an unusual autoimmune disease that causes partial or total hypopituitarism and often associated with chronic anovulation. We report a case of ovulation induction, uneventful pregnancy and vaginal delivery in one of our patient with lymphocystic hypophysitis. Key words: Lymphocystic hypophysitis, chronic anovulation and ovulation induction. doi:10.3126/njog.v3i1.1440 NJOG 2008 May-June; 3(1): 46 - 48
Placental site trophoblastic tumor with perimetrial invasion and cesarean scar perforation (A case report)
Authors: Gurung Geeta , Amatya Archana , Thakur Nupur , Rana Ashma 
Published: November 2008

Placental site trophoblastic tumor (PSTT) a rare variety of gestational trophobalstic neoplasia described in younger women, usually following term delivery characterized by low serum ß hCG level was met in a 32 year old lactating mother, who resumed normal menstruation after three months of cesarean section up to three cycles followed by amenorrhea for eight months; evacuation for presumed missed abortion prompted the diagnosis of PSTT which at the time of hysterectomy was found invading perimetrium and perforating the uterine cesarean scar. Conclusion: Careful evaluation of lactational amenorrhea is indicated so that the diagnosis of PSST may not be missed in the background of elusive picture such as missed abortion with low serum ß hCG, histological examination of the evacuated material may be relied which may provide the diagnosis at times. Key words: Placental site trophoblastic tumour (PSTT), hysterectomy, low serum ß hCG doi:10.3126/njog.v3i1.1443 NJOG 2008 May-June; 3(1): 55 - 57
Exposure to violent video games and aggression in German adolescents: a longitudinal analysis
Authors: Möller Ingrid , Krahé Barbara 
Published: November 2008

AbstractThe relationship between exposure to violent electronic games and aggressive cognitions and behavior was examined in a longitudinal study. A total of 295 German adolescents completed the measures of violent video game usage, endorsement of aggressive norms, hostile attribution bias, and physical as well as indirect/relational aggression cross‐sectionally, and a subsample of N=143 was measured again 30 months later. Cross‐sectional results at T1 showed a direct relationship between violent game usage and aggressive norms, and an indirect link to hostile attribution bias through aggressive norms. In combination, exposure to game violence, normative beliefs, and hostile attribution bias predicted physical and indirect/relational aggression. Longitudinal analyses using path analysis showed that violence exposure at T1 predicted physical (but not indirect/relational) aggression 30 months later, whereas aggression at T1 was unrelated to later video game use. Exposure to violent games at T1 influenced physical (but not indirect/relational) aggression at T2 via an increase of aggressive norms and hostile attribution bias. The findings are discussed in relation to social‐cognitive explanations of long‐term effects of media violence on aggression. Aggr. Behav. 35:75–89, 2009. © 2008 Wiley‐Liss, Inc.
Asymmetric Synthesis of Optically Pure Pharmacologically Relevant Amines Employing ω‐Transaminases
Authors: Koszelewski Dominik , Lavandera Iván , Clay Dorina , Rozzell David , Kroutil Wolfgang 
Published: November 2008

AbstractVarious ω‐transaminases were tested for the synthesis of enantiomerically pure amines from the corresponding ketones employing D‐ or L‐alanine as amino donor and lactate dehydrogenase to remove the side‐product pyruvate to shift the unfavourable reaction equilibrium to the product side. Both enantiomers, (R)‐ and (S)‐amines, could be prepared with up to 99% ee and >99% conversions within 24 h at 50 mM substrate concentration. The activity and stereoselectivity of the amination reaction depended on the ω‐transaminase and substrate employed; furthermore the co‐solvent significantly influenced both the stereoselectivity and activity of the transaminases. Best results were obtained by employing ATA‐117 to obtain the (R)‐enantiomer and ATA‐113 or ATA‐103 to access the (S)‐enantiomer with 15% v v−1 DMSO.
New Simple Hydrophobic Proline Derivatives as Highly Active and Stereoselective Catalysts for the Direct Asymmetric Aldol Reaction in Aqueous Medium
Authors: Giacalone Francesco , Gruttadauria Michelangelo , Meo Paolo Lo , Riela Serena , Noto Renato 
Published: November 2008

AbstractNew 4‐substituted acyloxyproline derivatives with different hydrophobic properties of the acyl group were easily synthesized and used as catalysts in the direct asymmetric aldol reaction between cyclic ketones (cyclohexanone and cyclopentanone) and several substituted benzaldehydes. Reactions were carried out using water, this being the best reaction medium examined. Screening of these catalysts showed that compounds bearing the most hydrophobic acyl chains [4‐phenylbutanoate and 4‐(pyren‐1‐yl)butanoate] provided better results. The latter catalysts were successfully used in only 2 mol% at room temperature without additives to give aldol products in excellent stereoselectivities. These results demonstrate that derivatization of the proline moiety with the proper simple hydrophobic substituent in the 4‐position can furnish highly active and stereoselective catalysts without the need of additional chiral backbones in the molecule. Finally, an explanation of the observed stereoselectivities in the presence of water is provided.
Sensitization to wheat flour and enzymes and associated respiratory symptoms in British bakers
Authors: Harris‐Roberts Joanne , Robinson Edward , Waterhouse Judith C. , Billings Catherine G. , Proctor Alison R. , Stocks‐Greaves Micah , Rahman Shamim , Evans Gareth , Garrod Andrew , Curran Andrew D. , Fishwick David 
Published: November 2008

AbstractRationaleCurrent literature suggests that flour exposed workers continue to be at risk of allergic sensitization to flour dust and respiratory ill health.ObjectivesA cross‐sectional study of 225 workers currently potentially exposed to flour dust in British bakeries was performed to identify predictors of sensitization to wheat flour and enzymes.ResultsWork‐related nasal irritation was the most commonly reported symptom (28.9%) followed by eye irritation (13.3%) and work‐related cough or chest tightness (both 10.2%). Work‐related chest tightness was significantly associated (OR 7.9, 1.3–46.0) with co‐sensitization to wheat flour and any added enzyme. Working at a bakery with inadequate control measures was not a risk factor for reporting work‐related respiratory symptoms (OR 1.3, 0.4–3.7). Fifty‐one workers were atopic and 23 (14%) were sensitized to workplace allergens. Atopy was the strongest predictive factor (OR 18.4, 5.3–64.3) determining sensitization. Current versus never smoking (OR 4.7, 1.1–20.8) was a significant risk factor for sensitization to wheat flour or enzymes in atopic workers only, corrected for current level and duration of exposure. This effect was not seen in non‐atopic workers (OR 1.9, 0.2–17.9). Evidence of sensitization to less commonly encountered allergens was also seen to Aspergillus niger derived cellulase, hemicellulase and xylanase mix, in addition to glucose oxidase and amyloglucosidase mix.ConclusionsThe combination of health surveillance and exposure control in this population has been insufficient to prevent clinically significant workplace sensitization. Smoking may pose an additional risk factor for sensitization in atopic workers. Am. J. Ind. Med. 52:133–140, 2009. © 2008 Crown copyright.
Upper extremity pain and computer use among engineering graduate students: A replication study
Authors: Menéndez Cammie Chaumont , Amick Benjamin C. , Jenkins Mark , Caroom Cyrus , Robertson Michelle , Harrist Ronald B. , Katz Jeffrey N. 
Published: November 2008

AbstractBackgroundRecent literature identified upper extremity musculoskeletal symptoms at a prevalence of >40% in college populations. The study objectives were to determine weekly computer use and the prevalence of upper extremity musculoskeletal symptoms in a graduate student population, and make comparisons with previous graduate and undergraduate cohorts.MethodsOne hundred sixty‐six graduate students completed a survey on computing and musculoskeletal health. Associations between individual factors and symptom status, functional limitations, academic impact, medication use, and health services utilization were determined. Logistic regression analyses evaluated the association between symptom status and computing. Cross‐study comparisons were made.ResultsMore symptomatic participants experienced functional limitations than asymptomatic participants (74% vs. 32%,P < 0.001) and reported medication use for computing pain (34% vs. 10%,P < 0.01). More participants who experienced symptoms within an hour of computing used health services compared to those who experienced symptoms after an hour of computer use (60% vs. 12%,P < 0.01). Years of computer use (OR = 1.59, 95% CI 1.05–2.40) and number of years in school where weekly computer use was more than 10 hr (OR = 1.56, 95% CI 1.04–2.35) were associated with pain within an hour of computing. Cross‐study comparisons found college populations more similar than different.ConclusionThe overall findings reinforced previous literature documenting the prevalence of upper extremity musculoskeletal symptoms in college populations, suggesting an important population for participating in public health interventions designed to support healthy computing practices and identify risk factors important to evaluate in future cohort studies. Am. J. Ind. Med. 52:113–123, 2009. © 2008 Wiley‐Liss, Inc.
Conformational study of poly‐ΔAbu peptides and construction of amphipathic nanostructure
Authors: Nandel Fateh S. , Sahrawat Tammanna R. 
Published: November 2008

AbstractGenerally, it is believed that α,β‐dehydroamino acid residues are most stable in the Z‐ form rather than in the E‐ form. In this study, it has been shown that poly‐ΔAbu exists in alternate ΔEAbu and ΔZAbu form, with ϕ, ψ values of ∼0°, 80° and 35°, 27° for the E‐ and Z‐ forms, respectively, rather than the all Z‐ form. The conformational results for the peptides Ac‐ΔAbu2‐NHMe and Ac‐L/D‐Ile‐ΔZAbu/ΔEAbu‐NHMe suggest the incorporation of ΔAbu in both the Z‐ and E‐ forms, which is consistent with the available observations in natural systems. Because of adoption of ϕ, ψ values corresponding to the collagen type structure (∼−30°, 120°) by Ile residue and with ϕ, ψ values in the left‐handed helical region for ΔZAbu residue, the peptide Ac‐(L‐Ile‐ΔZAbu)3‐NHMe adopts an amphipathic left‐handed helical β‐sheet type structure. This structure is stabilized by network of hydrogen bonding, carbonyl–carbonyl, and CH—O interactions and can be exploited for the construction of antimicrobial peptides and nanomaterials. © 2008 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 92: 44–51, 2009.This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com
Synthesis of benzofurazan derivatization reagents for short chain carboxylic acids in liquid chromatography/electrospray ionization‐tandem mass spectrometry (LC/ESI‐MS/MS)
Authors: Santa Tomofumi , Al‐Dirbashi Osama Y. , Yoshikado Takashi , Fukushima Takeshi , Imai Kazuhiro 
Published: November 2008

AbstractBenzofurazan derivatization reagents, 4‐[2‐(N,N‐dimethylamino)ethylaminosulfonyl]‐7‐(2‐aminopentylamino)‐2,1,3‐benzoxadiazole (DAABD‐AP) and 4‐[2‐(N,N‐dimethylamino) ethylaminosulfonyl]‐7‐(2‐aminobutylamino)‐2,1,3‐benzoxadiazole (DAABD‐AB), for short‐chain carboxylic acids in liquid chromatography/electrospray ionization tandem mass spectrometry (LC/ESI‐MS/MS) were synthesized. These reagents reacted with short chain carboxylic acids in the presence of the condensation reagents at 60°C for 60 min. The generated derivatives were separated on the reversed‐phase column and detected by ESI‐MS/MS with the detection limits of 0.1–0.12 pmol on column. Upon collision‐induced dissociation, a single and intense product ion at m/z 151 was observed. These results indicated that DAABD‐AP and DAABD‐AB are suitable as the derivatization reagents in LC/ESI‐MS/MS analysis. Copyright © 2008 John Wiley & Sons, Ltd.
Microseparation techniques for the study of the enantioselectivity of drug–plasma protein binding
Authors: Escuder‐Gilabert Laura , Martínez‐Gómez María Amparo , Villanueva‐Camañas Rosa María , Sagrado Salvador , Medina‐Hernández María José 
Published: November 2008

AbstractStereoselectivity in protein binding can have a significant effect on the pharmacokinetic and pharmacodynamic properties of chiral drugs. The investigation of enantioselectivity of drugs in their binding with human plasma proteins and the identification of the molecular mechanisms involved in the stereodiscrimination by the proteins represent a great challenge for clinical pharmacology. In this review, the separation techniques used for enantioselective protein binding experiments are described and compared. An overview of studies on enantiomer–protein interactions, enantiomer–enantiomer interactions as well as chiral drug–drug interactions, including allosteric effects, is presented. The contribution of individual plasma proteins to the overall enantioselective binding and the animal species variability in drug–plasma protein binding stereoselectivity are reviewed. Copyright © 2008 John Wiley & Sons, Ltd.
Determination of quinocide as impurity in primaquine tablets by capillary zone electrophoresis
Authors: Elbashir Abdalla A. , Saad Bahruddin , Ali Abdussalam Salhin Mohamed , Saleh Muhammad Idiris , Aboul‐Enein Hassan Y. 
Published: November 2008

AbstractA capillary zone electrophoretic method has been developed and validated for the determination of the impurity quinocide (QC) in the antimalarial drug primaquine (PQ). Different buffer additives such as native cyclodextrins and crown ethers were evaluated. Promising results were obtained when either β‐cyclodextrin (β‐CD) or 18‐crown‐6 ether (18C6) were used. Their separation conditions such as type of buffer and its pH, buffer additive concentration, applied voltage capillary temperature and injection time were optimized. The use of 18C6 offers slight advantages over β‐CD such as faster elution times and improved resolution. Nevertheless, migration times of less than 5 min and resolution factors (Rs) in the range of 2–4 were obtained when both additives were used. The method was validated with respect to selectivity, linearity, limits of detection and quantitation, analytical precision (intra‐ and inter‐day variability) and repeatability. Concentrations of 2.12 and 2.71% (w/w) of QC were found in pharmaceutical preparations of PQ from two different manufacturers. A possible mechanism for the successful separation of the isomers is also discussed. Copyright © 2008 John Wiley & Sons, Ltd.