bluuebunny/crossref_metadata_2025_split huggingface dataset:
Astrophysical supplements to the ASCC‐2.5: Ia. Radial velocities of ∼55000 stars and mean radial velocities of 516 Galactic open clusters and associations
Authors: Kharchenko N.V. , Scholz R.‐D. , Piskunov A.E. , Röser S. , Schilbach E. 
Published: October 2007

AbstractWe present the 2nd version of the Catalogue of Radial Velocities with Astrometric Data (CRVAD‐2). This is the result of the cross‐identification of stars from the All‐Sky Compiled Catalogue of 2.5 Million Stars (ASCC‐2.5) with the General Catalogue of Radial Velocities and with other recently published radial velocity lists and catalogues. The CRVAD‐2 includes accurate J2000 equatorial coordinates, proper motions and trigonometric parallaxes in the Hipparcos system, B, V photometry in the Johnson system, spectral types, radial velocities (RVs), multiplicity and variability flags for 54907 ASCC‐2.5 stars. We have used the CRVAD‐2 for a new determination of mean RVs of 363 open clusters and stellar associations considering their established members from proper motions and photometry in the ASCC‐2.5. For 330 clusters and associations we compiled previously published mean RVs from the literature, critically reviewed and partly revised them. The resulting Catalogue of Radial Velocities of Open Clusters and Associations (CRVOCA) contains about 460 open clusters and about 60 stellar associations in the Solar neighbourhood. These numbers still represent less than 30% of the total number of about 1820 objects currently known in the Galaxy. The mean RVs of young clusters are generally better known than those of older ones. (© 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Correcting second‐order contamination in low‐resolution spectra
Authors: Stanishev V. 
Published: October 2007

AbstractAn empirical method for correcting low‐resolution astronomical spectra for second‐order contamination is presented. The method was developed for correcting spectra obtained with grism#4 of the ALFOSC spectrograph at the Nordic Optical Telescope and the performance is demonstrated on spectra of two nearby bright Type Ia supernovae. (© 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Comparison of dust‐to‐gas ratios in luminous, ultraluminous, and hyperluminous infrared galaxies
Authors: Contini M. , Contini T. 
Published: October 2007

AbstractThe dust‐to‐gas ratios in three different samples of luminous, ultraluminous, and hyperluminous infrared galaxies are calculated by modelling their radio to soft X‐ray spectral energy distributions (SED) using composite models which account for the photoionizing radiation from H II regions, starbursts, or AGNs, and for shocks. The models are limited to a set which broadly reproduces the mid‐IR fine structure line ratios of local, IR bright, starburst galaxies. The results show that two types of clouds contribute to the IR emission. Those characterized by low shock velocities and low preshock densities explain the far‐IR dust emission, while those with higher velocities and densities contribute to the mid‐IR dust emission. Clouds with shock velocities of 500 km s–1 prevail in hyperluminous infrared galaxies. An AGN is found in nearly all of the ultraluminous infrared galaxies and in half of the luminous infrared galaxies of the sample. High IR luminosities depend on dust‐to‐gas ratios as high as ∼0.1 by mass, however most hyperluminous IR galaxies show dustto‐gas ratios much lower than those calculated for the luminous and ultraluminous IR galaxies. (© 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Formation and temperature stability of G‐quadruplex structures studied by electronic and vibrational circular dichroism spectroscopy combined with ab initio calculations
Authors: Nový Jakub , Böhm Stanislav , Králová Jarmila , Král Vladimír , Urbanová Marie 
Published: October 2007

AbstractVariations in the structure of d(GGGA)5 oligonucleotide in the presence of Li+, Na+, and K+ ions and its temperature stability were studied using electronic and vibrational circular dichroism, IR absorption, and ab initio calculations with the Becke 3‐Lee‐Yang‐Parr functional at the 6‐31G** level. The samples were characterized by nondenaturing gel electrophoresis. Oligonucleotide d(GGGA)5 in the presence of Li+ forms a nonplanar single tetramer, with angles of 102° and 171° between neighboring guanine bases. This tetramer changes its geometry at temperatures >50°C, but does not form a quadruplex structure. In the presence of Na+, the d(GGGA)5 structure was optimized to almost planar tetramers with an angle of 177° between neighboring guanines. The spectral results suggest that it stacks into a quadruplex helical structure. This quadruplex structure decayed to a single tetramer at temperatures >60°C. The Hartree–Fock energies imply that d(GGGA)5 prefers to form complexes with Na+ rather than Li+. The d(GGGA)5 structure in the presence of monovalent ions is stabilized against thermal denaturation in the order Li+ < Na+ < K+. © 2007 Wiley Periodicals, Inc. Biopolymers 89: 144–152, 2008.This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com
Percutaneous occlusion of posttraumatic aortic arch pseudoaneurysm by catheter‐based delivery of thrombin
Authors: Buhr Christiane , Eggebrecht Holger , Erbel Raimund 
Published: October 2007

AbstractPurpose: To report a patient in whom a posttraumatic pseudoaneurysm of the aortic arch was successfully treated by catheter‐based delivery of thrombin with balloon occlusion of the entry tear. Case Report: A 63‐year‐old male presented with pseudoaneurysm of the aortic arch after blunt chest trauma which was detected incidentally during routine chest X‐ray. Using a percutaneous transfemoral approach, a 5 French Swan‐Ganz catheter could be positioned into the aneurysm sac. Under balloon occlusion of the entry tear in order to prevent systemic embolization, 1,000 units of bovine thrombin were injected into the aneurysm sac resulting in complete occlusion of the aneurysm. Contrast‐enhanced computed tomographic control showed complete thrombosis of the aneurysm over a follow‐up period of 12 months. Conclusion: Percutaneous catheter‐based delivery of thrombin is a feasible and effective minimally‐invasive treatment alternative for patients with thoracic aortic pseudoaneurysms. © 2007 Wiley‐Liss, Inc.
Isostructural Materials Achieved by Using Structurally Equivalent Donors and Acceptors in Halogen‐Bonded Cocrystals
Authors: Cinčić Dominik , Friščić Tomislav , Jones William 
Published: October 2007

AbstractWe demonstrate the supramolecular and structural equivalence of two halogen‐bond donors (I and Br) and three acceptors (O, NH and S) through the synthesis of seven isostructural halogen‐bonded cocrystals, involving six different molecules: 1,4‐dibromo‐ and 1,4‐diiodotetrafluorobenzene (donors) and thiomorpholine, thioxane, morpholine, and piperazine (acceptors). The formation of isostructural cocrystals indicates how cocrystallization may be used to overcome shape and functional group dissimilarities that control molecular arrangement in the solid state. The differences in composition between the seven isostructural cocrystals directly affect the strength and nature of halogen bonds between their constituents, allowing the systematic variation of cocrystal physical properties, in particular the melting point, without affecting their crystal structure. Replacement of each O or S halogen‐bond acceptor with an NH group provided an approximate 70 °C increase in melting point, whereas the replacement of I with Br as the halogen‐bond donor lowered the melting point of the resulting solid by a similar amount.
Management Strategies for Stage‐D Patients with Acute Heart Failure
Authors: Feldman David , Menachemi Doron M. , Abraham William T. , Wexler Randell K. 
Published: October 2007

AbstractHeart Failure (HF) accounted for 3.4 million ambulatory visits in 2000. Current guidelines from the American Heart Association/American College of Cardiology, the Heart Failure Society of America, and the International Society for Heart & Lung Transplantation recommend aggressive pharmacologic interventions for patients with HF. This may include a combination of diuretics, Angiotensin Converting Enzyme inhibitors, β‐blockers, angiotensin receptor blockers, aldosterone antagonists, and digoxin. Nitrates and hydralazine are also indicated as part of standard therapy in addition to β‐blockers and Angiotensin Converting Enzyme inhibitors, especially but not exclusively, for African Americans with left ventricular (LV) systolic dysfunction. For those with acute decompensated HF, additional treatment options include recombinant human B‐type natriuretic peptide, and in the future possible newer agents not yet approved for use in the U.S., such as Levosimendan. Medical devices for use in patients with advanced HF include LV assist devices, cardiac resynchronization therapy, and implantable cardioverter defibrillators. For refractory patients, heart transplantation, the gold‐standard surgical intervention for the treatment of refractory HF, may be considered. Newer surgical options such as surgical ventricular restoration may be considered in select patients. Copyright © 2007 Wiley Periodicals, Inc.
Identification of alpha‐actinin 4 and 67 kDa laminin receptor as stage‐specific markers in esophageal cancer via proteomic approaches
Authors: Fu Li , Qin Yan Ru , Xie Dan , Chow Hoi Yee , Ngai Sai Ming , Kwong Dora L. W. , Li Yan , Guan Xin Yuan 
Published: October 2007

AbstractBACKGROUND.Esophageal squamous cell carcinoma (ESCC) is one of the most common malignancies in the world with a very poor prognosis. The majority of ESCC patients present with advanced metastatic disease upon diagnosis. Therefore, it is important to understand the molecular mechanism in the tumor invasion process and to find new biomarkers for early diagnosis and prognostic evaluation.METHODS.Differentially expressed proteins among different stages of primary ESCCs and their matched surrounding normal tissues were compared by proteomics‐based technology. The correlations between interesting proteins and clinical features of ESCC were further investigated by using ESCC tissue microarray (TMA) by immunohistochemical staining.RESULTS.Compared with normal tissues, a total of 18 differentially expressed proteins were identified in ESCC in this study. Among them, expression levels of alpha‐actinin 4 (ACTN4) and 67 kDa laminin receptor (67LR) were progressively increased from stage I to III. Clinicopathological correlation using TMA revealed that overexpression of ACTN4 was significantly associated with advanced tumor stage (P = .026) and lymph node metastasis (P = .049), whereas overexpression of 67LR was significantly correlated with advanced tumor stage (P = .019) but not lymph node metastasis.CONCLUSIONS.These findings suggested that overexpression of ACTN4 and 67 LR is associated with ESCC progression and that these biomarkers may potentially be useful to prognostic evaluation, molecular biological classification, and therapeutic targeting. Cancer 2007. © 2007 American Cancer Society.
Higher prostate‐specific antigen levels predict improved survival in patients with hormone‐refractory prostate cancer who have skeletal metastases and normal serum alkaline phosphatase
Authors: Xie Wanling , Nakabayashi Mari , Regan Meredith M. , Oh William K. 
Published: October 2007

AbstractBACKGROUND.Higher prostate‐specific antigen (PSA) and alkaline phosphatase (ALK‐P) levels predicted worse survival in men with metastatic hormone‐refractory prostate cancer (HRPC). In the current study, the authors evaluated the combined effects of PSA and ALK‐P on survival.METHODS.Two hundred twenty‐four men who had HRPC with bone metastases and who were receiving chemotherapy were identified, and 143 of those men had data available on both ALK‐P and PSA levels at chemotherapy initiation. The primary endpoint of the study was overall survival (OS) after chemotherapy. The men were dichotomized into normal and abnormal ALK‐P groups according to levels based on institutional normal ranges. The effect of PSA was evaluated as both a categorical value and a continuous value using Cox regression.RESULTS.Eighty‐nine of 143 patients (62%) had elevated ALK‐P levels. The median PSA was 147 ng/mL (93 ng/mL in patients with normal ALK‐P, 171 ng/mL in patients with elevated ALK‐P). At a median follow‐up of 30 months after chemotherapy initiation, 93 patients had died. The median OS after chemotherapy was 15.8 months (95% confidence interval, 12.8–18.4 months) and was significantly longer if ALK‐P was in the normal range (21.3 months vs 14 months; P = .005). For the group with normal ALK‐P levels, the median OS was 12.5 months, 24.5 months, and 36.9 months for patients with low, medium, and high PSA levels, respectively. In contrast, the effect of PSA on survival was not as evident in the group with elevated ALK‐P levels (16.5 months vs 11.9 months vs 12.1 months, respectively; P = .14 for interaction). Age‐adjusted multivariate analysis demonstrated statistically significant interactions of PSA and ALK‐P with OS (P = .02).CONCLUSIONS.ALK‐P significantly predicted OS in men with HRPC who had bone metastases. In patients with normal ALK‐P levels, higher PSA levels were associated with improved survival. Cancer 2007. © 2007 American Cancer Society.
Supramolecular Chemistry of Acyclic Oligopyrroles (Eur. J. Org. Chem. 32/2007)
Authors: Maeda Hiromitsu 
Published: October 2007

AbstractThe cover picture shows the two representative characteristics of pyrrole, “duality” as a hydrogen‐bonding acceptor (or a metal‐coordination ligand) N and a hydrogen‐bonding donor (or an anion‐binding ligand) NH and “planarity” to form stacking assemblies, depicted by the disks of Yin and Yang. Acyclic π‐conjugated oligopyrrole derivatives, though less extensively studied so far, often potentially have even more advantages than cyclic ones. For example, the linear oligopyrroles prepared by the author form infinite and discrete coordination oligomers to give emissive spherical colloids and nanorings, hydrogen‐bonding supramolecular assemblies to afford unique crystalline morphologies, and stacking structures to yield organogels that can be controlled by anions. Details are presented in the Microreview by H. Maeda on p. 5313 ff. This picture has been provided by Mr. Takashi Hashimoto, one of the members in the author's group.
Electrochemical Studies on New Chelating Compounds of the Mono‐ and Bis(imidazolyl)pyridine Type
Authors: Mikysek Tomáš , Švancara Ivan , Bartoš Martin , Vytřas Karel , Drabina Pavel , Sedlák Miloš , Klíma Jiří , Urban Jiří , Ludvík Jiří 
Published: October 2007

AbstractRecently designed and synthetized mono‐imidazolinone (I and III) and bisimidazolinone (II and IV) chelating ligands were electrochemically characterized at mercury and carbon paste electrodes. Based on polarographic, voltammetric and coulometric investigations in buffered aqueous media, the general reduction pathway has been suggested. Reduction of the mono‐imidazolinone derivatives proceeds in acidic and neutral media in two two‐electron steps. In the first step, the 2,3‐CN double bond of the imidazolone ring is reduced yielding a mixture of two diastereoisomers (V and VI). In the second step, the 2,3‐CN single bond (in protonated form) is further reductively split and as the only final product the compound VII was formed. Both intermediates (V and VI) as well as the final product (VII) were prepared using controlled potential electrolysis on the first and second wave, respectively, isolated and identified by means of NMR. The reduction of bis‐derivatives proceeds most probably in an analogical way: in the first step, both imidazoles are reduced simultaneously at the same potential, whereas the following reduction (ring‐opening) proceeds stepwise. In the case of compound III, the covalent hydration of the parent compound takes place in acidic media, partially preventing its reduction. Finally, voltammetric behaviour of mono‐ and bisimidazolinones at carbon paste electrode is also discussed and, in prospect, possible electroanalytical applications outlined.
Type I collagen expression contributes to angiogenesis and the development of deeply invasive cutaneous melanoma
Authors: van Kempen Léon C.L.T. , Rijntjes Jos , Mamor‐Cornelissen Ine , Vincent‐Naulleau Silvia , Gerritsen Marie‐Jeanne P. , Ruiter Dirk J. , van Dijk Marcory C.R.F. , Geffrotin Claudine , van Muijen Goos N.P. 
Published: October 2007

AbstractTumors are complex tissues composed of neoplastic cells, soluble and insoluble matrix components and stromal cells. Here we report that in melanoma, turn‐over of type I collagen (Col(I)), the predominant matrix protein in dermal stroma affects melanoma progression. Fibroblasts juxtaposed to melanoma cell nests within the papillary dermis display high levels of Col(I) mRNA expression. These nests are enveloped by collagen fibers. In contrast, melanoma‐associated fibroblasts within the reticular dermis express Col(I) mRNA at a level that is comparable to its expression in uninvolved dermis and reduced amount of collagen protein can be observed. To determine the significance of Col(I) expression in melanoma, we pharmacologically inhibited its transcription in a porcine cutaneous melanoma model by oral administration of halofuginone. When administered before melanoma development, it reduced melanoma incidence and diminished the transition from microinvasive toward deeply invasive growth by limiting the development of a tumor vasculature. Whereas invasive melanoma growth has been correlated with increased blood vessel density previously, our data for the first time demonstrate that the proangiogenic effect of Col(I) expression by fibroblasts and vascular cells precedes the development of invasive melanomas in a de novo tumor model. © 2007 Wiley‐Liss, Inc.
Helicobacter hepaticus promotes azoxymethane‐initiated colon tumorigenesis in BALB/c‐IL10‐deficient mice
Authors: Nagamine Claude M. , Rogers Arlin B. , Fox James G. , Schauer David B. 
Published: October 2007

AbstractThe BALB/c‐IL10 null mouse strain develops colitis and colitis‐associated adenocarcinomas, and is a model for idiopathic inflammatory bowel disease. We tested the hypotheses that (i) azoxymethane (AOM), a carcinogen that targets the colon, synergizes with the colonic inflammation inherent in the BALB/c‐IL10 null mouse resulting in an increase in incidence, multiplicity and/or progression of AOM‐induced tumors or colitis‐associated adenocarcinomas; and (ii) prior infection with Helicobacter hepaticus, a common enterohepatic bacterial pathogen in many research mouse colonies, increases the incidence, multiplicity and/or progression of AOM‐induced colon tumors or colitis‐associated adenocarcinomas in the BALB/c‐IL10 null mouse. We show that, within the timeframe examined, AOM‐induced colon tumors in the BALB/c‐IL10 null mouse were grossly and microscopically similar in appearance to AOM‐induced colon tumors in the wild type BALB/cJ mouse. No colitis‐associated adenocarcinomas were identified. Infection with H. hepaticus prior to AOM‐treatment also did not result in colitis‐associated adenocarcinomas but did result in a significant increase in the incidence of AOM‐induced colon tumors relative to AOM treatment alone. The AOM‐induced adenomas were predominantly exophytic and nodular or polypoid and localized to the distal colon. These results suggest that H. hepaticus promotes AOM‐induced tumorigenesis in the BALB/c‐IL10 null mouse. © 2007 Wiley‐Liss, Inc.
IQGAP2 inactivation through aberrant promoter methylation and promotion of invasion in gastric cancer cells
Authors: Jin Shun‐Hua , Akiyama Yoshimitsu , Fukamachi Hiroshi , Yanagihara Kazuyoshi , Akashi Takumi , Yuasa Yasuhito 
Published: October 2007

AbstractInvasion and metastases of cancer cells are the main causes of treatment failure in cancer. IQ motif‐containing GTPase activating protein 1 (IQGAP1), plays pivotal roles in intercellular adhesion, migration, invasion and metastases in various cancer cells. However, the role of another family member, IQGAP2, in carcinogenesis remains unknown. Here, we investigated IQGAP2 functions in gastric cancers. We found that IQGAP2 protein expression was lost in 5 of the 9 gastric cancer cell lines. Through analysis by the methylation‐specific PCR, aberrant IQGAP2 methylation was detected in 3 gastric cancer cell lines. IQGAP2 mRNA was found to be activated after 5‐aza‐2′‐deoxycytidine treatment of the methylation‐positive cells. Moreover, IQGAP2 methylation was detected in 28 of the 59 (47%) primary gastric cancer tissues, but not in 12 normal gastric mucosa samples. Immunohistochemical staining revealed that 7 of the 8 (88%) gastric cancer tissues without methylation signals displayed IQGAP2 expression, whereas among 10 with methylation signals none expressed IQGAP2 (p = 0.0002), indicating that IQGAP2 methylation is highly associated with loss of the IQGAP2 expression in the primary gastric cancer tissues as well as gastric cancer cell lines. Furthermore, IQGAP2 methylation was also associated with tumor invasion and a poor prognosis. IQGAP2 knockdown with small interfering RNA increased the invasive capacity of a gastric cancer cell line. These results suggest that silencing of IQGAP2 by promoter methylation may contribute to gastric cancer development. © 2007 Wiley‐Liss, Inc.
Persistent use of “false” cell lines
Authors: Lacroix Marc 
Published: October 2007

AbstractFrom HeLa and its multiple identities, to MDA‐MB‐435, erroneously and widely used as breast cancer cells, the history of cancer cell lines is rich in misidentification and cross‐contamination events. Despite the fact that these problems were regularly signaled during the last decades, many actors of research still seem to ignore them. A never‐ending story? Solutions exist, notably based on recent technical advances in cell line authentication (short tandem repeat analysis). However, a collaborative action involving users of cell lines, cell banks, journals and funding agencies is needed to achieve success. © 2007 Wiley‐Liss, Inc.
Intracellular delivery enhancement of poly(amino acid) drug carriers by oligoarginine conjugation
Authors: Yang Seung Rim , Kim Seung Beom , Joe Cheol O. , Kim Jong‐Duk 
Published: October 2007

AbstractPoly(2‐hydroxytethyl aspartamide) (PHEA) was effectively translocated in both fixed and unfixed HeLa cells, when oligoarginine (Arg8) known as one of the cell‐penetrating peptides was conjugated via a thioether linkage. The internalization of PHEA‐Arg8 into cells was a temperature‐dependent process, and the studies at endocytosis inhibition conditions suggested that an endocytosis was a key mechanism. The fluorescence spectra of PHEA‐Arg8 in liposome solutions showed that PHEA‐Arg8 was collectively adsorbed in the negative liposome membrane due to the high cationic property of a conjugated Arg8, representing that a surface adsorption was a first step in the internalization of PHEA‐Arg8. The membrane leakage activity of PHEA‐Arg8 was much lower than that of Arg8 own, meaning that PHEA‐Arg8 does not effectively disrupt the cell membrane integrity. The uptake of polymer con&&num;132;jugates increased with the incubation time and reached saturation after several hours. The increase in the number of &&num;132;peptide conjugated to one polymer chain could increase the collective adsorption of polymer conjugates and enhance the cellular uptake. Thus, it is believed that PHEA‐Arg8 could be internalized by an adsorptive‐endocytosis. A model conjugate of PHEA‐Arg8 with methotrexate (PHEA‐MTX‐Arg8) inhibited the cell proliferation about several orders of magnitude more active than PHEA‐MTX. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2008