bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic impact of clinicopathologic parameters in stage II/III breast cancer treated with neoadjuvant docetaxel and doxorubicin chemotherapy: paradoxical features of the triple negative breast cancer
Authors: Keam Bhumsuk , Im Seock-Ah , Kim Hee-Jun , Oh Do-Youn , Kim Jee Hyun , Lee Se-Hoon , Chie Eui Kyu , Han Wonshik , Kim Dong-Wan , Moon Woo Kyung , Kim Tae-You , Park In Ae , Noh Dong-Young , Heo Dae Seog , Ha Sung Whan , Bang Yung-Jue 
Published: November 2007

Abstract

Background
Prognostic factors in locally advanced breast cancer treated with neoadjuvant chemotherapy differ from those of early breast cancer. The purpose of this study was to identify the clinical significance of potential predictive and prognostic factors in breast cancer patients treated by neoadjuvant chemotherapy.

Methods
A total of 145 stage II and III breast cancer patients received neoadjuvant docetaxel/doxorubicin chemotherapy were enrolled in this study. We examined the clinical and biological factors (ER, PR, p53, c-erbB2, bcl-2, and Ki-67) by immunohistochemistry. We analyzed clinical outcome and their correlation with clinicopathologic parameters.

Results
Among the clinicopathologic parameters investigated, none of the marker was correlated with response rate (RR) except triple negative phenotype. Patients with triple negative phenotype showed higher RR (83.0% in triple negative vs. 62.2% in non-triple negative, p = 0.012) and pathologic complete RR (17.0% in triple negative vs. 3.1% in non-triple negative, p = 0.005). However, relapse free survival (RFS) and overall survival (OS) were significantly shorter in triple negative breast cancer patients (p < 0.001, p = 0.021, respectively). Low histologic grade, positive hormone receptors, positive bcl-2 and low level of Ki-67 were associated with prolonged RFS. In addition, positive ER and positive bcl-2 were associated with prolonged OS. In our homogeneous patient population, initial clinical stage reflects RFS and OS more precisely than pathologic stage. In multivariate analysis, initial clinical stage was the only significant independent prognostic factor to impact on OS (hazard ratio 3.597, p = 0.044).

Conclusion
Several molecular markers provided useful predictive and prognostic information in stage II and III breast cancer patients treated with neoadjuvant docetaxel/doxorubicin chemotherapy. Triple negative phenotype was associated with shorter survival, even though it was associated with a higher response rate to neoadjuvant chemotherapy.
Exposure of bakery and pastry apprentices to airborne flour dust using PM2.5 and PM10personal samplers
Authors: Mounier-Geyssant Estelle , Barthélemy Jean-François , Mouchot Lory , Paris Christophe , Zmirou-Navier Denis 
Published: November 2007

Abstract

Background
This study describes exposure levels of bakery and pastry apprentices to flour dust, a known risk factor of occupational asthma.

Methods
Questionnaires on work activity were completed by 286 students. Among them, 34 performed a series of two personal exposure measurements using a PM2.5 and PM10 personal sampler during a complete work shift, one during a cold ("winter") period, and the other during a hot ("summer") period.

Results
Bakery apprentices experience greater average PM2.5 and PM10 exposures than pastry apprentices (p < 0.006). Exposure values for both particulate fractions are greater in winter (average PM10 values among bakers = 1.10 mg.m-3 [standard deviation: 0.83]) than in summer (0.63 mg.m-3 [0.36]). While complying with current European occupational limit values, these exposures exceed the ACGIH recommendations set to prevent sensitization to flour dust (0.5 mg.m-3). Over half the facilities had no ventilation system.

Conclusion
Young bakery apprentices incur substantial exposure to known airways allergens, a situation that might elicit early induction of airways inflammation.
Comparison of glucosamine sulfate and a polyherbal supplement for the relief of osteoarthritis of the knee: a randomized controlled trial [ISRCTN25438351]
Authors: Mehta Komal , Gala Jayesh , Bhasale Surendra , Naik Sattayasheel , Modak Millind , Thakur Harshad , Deo Nivedita , Miller Mark JS 
Published: November 2007

Abstract

Background
The efficacy and safety of a dietary supplement derived from South American botanicals was compared to glucosamine sulfate in osteoarthritis subjects in a Mumbai-based multi-center, randomized, double-blind study.

Methods
Subjects (n = 95) were screened and randomized to receive glucosamine sulfate (n = 47, 1500 mg/day) or reparagen (n = 48, 1800 mg/day), a polyherbal consisting of 300 mg of vincaria (Uncaria guianensis) and 1500 mg of RNI 249 (Lepidium meyenii) administered orally, twice daily. Primary efficacy variable was response rate based on a 20% improvement in WOMAC pain scores. Additional outcomes were WOMAC scores for pain, stiffness and function, visual analog score (VAS) for pain, with assessments at 1, 2, 4, 6 and 8 weeks. Tolerability, investigator and subject global assessments and rescue medication consumption (paracetamol) were measured together with safety assessments including vital signs and laboratory based assays.

Results
Subject randomization was effective: age, gender and disease status distribution was similar in both groups. The response rates (20% reduction in WOMAC pain) were substantial for both glucosamine (89%) and reparagen (94%) and supported by investigator and subject assessments. Using related criteria response rates to reparagen were favorable when compared to glucosamine. Compared to baseline both treatments showed significant benefits in WOMAC and VAS outcomes within one week (P < 0.05), with a similar, progressive improvement over the course of the 8 week treatment protocol (45–62% reduction in WOMAC or VAS scores). Tolerability was excellent, no serious adverse events were noted and safety parameters were unchanged. Rescue medication use was significantly lower in the reparagen group (p < 0.01) at each assessment period. Serum IGF-1 levels were unaltered by treatments.

Conclusion
Both reparagen and glucosamine sulfate produced substantial improvements in pain, stiffness and function in subjects with osteoarthritis. Response rates were high and the safety profile was excellent, with significantly less rescue medication use with reparagen. Reparagen represents a new natural productive alternative in the management of joint health.

Trial registration
Current Controlled Trials ISRCTN25438351.
Highly Selective Extraction of TcO4−, ReO4−, and MoO42− by the New Ligand, 2,2′-(Methylimino)bis(N,N-Dioctylacetamide) (MIDOA)
Authors: Sasaki Yuji , Kitatsuji Yoshihiro , Kimura Takaumi 
Published: November 2007

Abstract
Highly selective extraction of oxonium anions can be achieved by the new ligand, 2,2′-(methylimino)bis(N,N-dioctylacetamide) (MIDOA). MIDOA has a high solubility in n-dodecane, any types of diluents can be employed for the solvent extraction. The extraction using MIDOA was performed under the condition, HNO3 and n-dodecane, considering the chemical process of high-level radioactive liquid waste. It was obvious that the oxonium anions, like TcO4−, ReO4−, Cr2O72−, MoO42−, and WO42−, are extracted, and the distribution ratios (D) decrease with increase of HNO3 concentration.
Simultaneous Spectrophotometric Determination of Ozone and Hydrogen Peroxide
Authors: Kitsuka Kenta , Mohammad Ahmad M , Awad Mohamed Ismail , Kaneda Kazuhiro , Ikematsu Mineo , Iseki Masahiro , Mushiake Katsuhiko , Ohsaka Takeo 
Published: November 2007

Abstract
A simple, rapid, and highly selective spectrophotometric method for the simultaneous analysis of ozone (O3) and hydrogen peroxide (H2O2) is proposed. On the basis of the large difference in the reaction rates of O3 and H2O2 with I−, a changed absorbance corresponding to the reactions of the two species with I− was observed. This method enables a highly selective simultaneous analysis of O3 and H2O2 in their coexistence.
Measuring the Electronic Decay Constant of Alkanedithiols by Electrochemical Impedance Spectroscopy
Authors: Zhang Yumei , Ma Qingwei , Zhang Hongming , Zhu Guoyi 
Published: November 2007

Abstract
Several methods have been used for the measurement of the electronic decay constant (β) of organic molecules. However, each of them has some disadvantages. For the first time, electrochemical impedance spectroscopy (EIS) was used to obtain the β value by measuring the tunneling resistance through alkanedithiols. The tunneling resistance through alkanedithiols increases exponentially with the molecular length in terms of the mechanism of coherent nonresonant tunneling. β was 0.51±0.01 per carbon.
Oxidation of Secondary Benzylic Alcohols to Ketones by Activated Carbon–Molecular Oxygen System
Authors: Sano Yuki , Tanaka Takanori , Hayashi Masahiko 
Published: November 2007

Abstract
A variety of benzylic alcohols were oxidized to the corresponding carbonyl compounds selectively in the presence of activated carbon under molecular oxygen atmosphere. This process does not require any metal oxides, thus this is environmentally friendly and economical.
Rapid and Deep Nitridation of Silica MCM-41 without Loss of Hexagonal Pore Structure
Authors: Ishizu Ken-ichi , Hayashi Fumitaka , Iwamoto Masakazu 
Published: November 2007

Abstract
The nitridation of mesoporous silica MCM-41 with ammonia was carried out by using a plug flow-type reactor. The degree of nitridation was dependent on the amount of NH3 supplied. Mesoporous silicon oxynitride containing 34 wt % of nitrogen could be prepared at 1273 K for 8 h, and the hexagonal mesoporous structure was maintained.
Benzylation of α-Diimine Ligands Bound to Zirconium and Hafnium. A New Convenient Route to Olefin Polymerization Catalysts
Authors: Mashima Kazushi , Ohnishi Ryuji , Yamagata Tsuneaki , Tsurugi Hayato 
Published: November 2007

Abstract
Reactions of M(CH2Ph)4 (M = Zr and Hf) with α-diimine ligands 1 at −78 °C selectively afford tribenzyl amido–imino complexes of zirconium 4 and hafnium 5, whose treatment with B(C6F5)3 gave the corresponding cationic dibenzyl complexes 6 and 7 capable of polymerizing 1-hexene.
Copper(I)- and Gold(I)-catalyzed Synthesis of 2,4-Disubstituted Quinoline Derivatives from N-Aryl-2-propynylamines
Authors: Kuninobu Yoichiro , Inoue Yuichi , Takai Kazuhiko 
Published: November 2007

Abstract
2,4-Disubstituted quinoline derivatives were obtained from N-aryl-2-propynylamines catalyzed by copper(I) and gold(I) complexes. The quinoline derivatives could also be obtained by the reaction of N-arylaldimines with terminal acetylenes via the formation of N-aryl-2-propynylamines.
Implementation of sorption hysteresis in multi-Fickian moisture transport
Authors: Lund Frandsen Henrik , Svensson Staffan 
Published: November 2007

Abstract
In the cellular structure of wood, bound-water diffusion and water-vapor diffusion interact via sorption in a complex moisture-transportation system. At low relative humidities, moisture transport may be modeled by a Fickian diffusion equation with a good approximation. At higher relative humidities, slow sorption and faster bound-water diffusion cause effects, which have been referred to as non-Fickian or anomalous, as they cannot be modeled by one Fickian diffusion equation. Previous research has demonstrated that a set of coupled diffusion equations, namely the multi-Fickian model, can represent this behavior. The multi-Fickian model describes the combined transport of bound water and vapor and their interaction through sorption. The bound-water concentration is also influenced by sorption hysteresis. In the worst case, sorption hysteresis may result in deviations of up to 30–35% in moisture content. Hence, for a precise moisture content computation, sorption hysteresis must be taken into account. The present paper explains the relation between sorption hysteresis and multi-Fickian moisture transport, and clarifies how models for the two phenomena are coupled. To illustrate the effects, a finite element simulation, which is based on the combined model, is presented.
Analysis of wood tissues by time-of-flight secondary ion mass spectrometry
Authors: Tokareva Elena N. , Pranovich Andrey V. , Fardim Pedro , Daniel Geoffrey , Holmbom Bjarne 
Published: November 2007

Abstract
The distribution of lignin, carbohydrates, and metal ions on the surface of spruce and aspen wood tissue sections was investigated by time-of-flight secondary ion mass spectrometry (ToF-SIMS). The distribution patterns of metals and lignin in ray cells, vessels, and fibres were different, whereas carbohydrates were uniformly distributed across the sections of all morphological regions. In spruce sapwood, Ca, Mg, Na, K, Fe locations was more pronounced in the bordered pit tori and inner layer of ray parenchyma cells. Little lignin was detected in these regions. In spruce heartwood, the degree of lignification was low on the surfaces of bordered pit tori; however, Na and K were not detected here. In compression wood from spruce, the locations of p-hydroxyphenyl and guaiacyl units was different in cell wall layers. In aspen sapwood, the main locations of Ca, Mg, Na, K were in lumina of longitudinal parenchyma cells and in pits between vessels and ray cells. Low-intensity signals of the secondary ions assigned to lignin were found in the same morphological regions.
Neptunium(V) disproportionation and cation–cation interactions in TBP/kerosene solvent
Authors: Sarsfield Mark J. , Taylor Robin J. , Maher Chris J. 
Published: November 2007

Summary
In 30% TBP/OK Np(V) is unstable and disproportionates to Np(IV) and Np(VI). Np(V) readily coordinates to Np(IV) in solution to form a “cation–cation” complex by bonding through an axial oxo group on Np(V). The rate of disproportionation in 30% TBP/OK is >500 times that in aqueous solution.
A kinetic study of UO2 dissolution and H2O2 stability in the presence of groundwater ions
Authors: Amme Marcus , Svedkauskaite J. , Bors W. , Murray M. , Merino J. 
Published: November 2007

Summary
Current reactors spent nuclear UO2 fuel, that will probably enter geologic formations for disposal, is assumed to get into contact with groundwater of a repository earliest after several thousands of years. After this time, its alpha activity will be still high enough to induce a process of water radiolysis that leads to production of oxidants and, probably, to the oxidative dissolution of the material, that could start a mobilisation of radiotoxic nuclides. The main oxidant produced during this process would be hydrogen peroxide (H2O2), which is thermodynamically unstable and can decompose during reactions with certain groundwater ions. Information on the stability of H2O2 is therefore important for assessing the behaviour of the material in the repository.
We investigated the stability of H2O2 and the correlated dissolution of U from UO2 as a function of the concentration of H2O2 and of the groundwater ions carbonate, sulphate, and silicate. Decomposition of H2O2 was measured in the presence and absence of UO2(cr). We monitored the concentrations of H2O2, Udiss, groundwater ions, O2diss, and the pH in aqueous solution under Ar atmosphere. The lowest stabilities (in average) for H2O2 were found in carbonate solutions. When comparing the effect of carbonate systems containing UO2(cr) to carbonate solutions without a solid phase, we found that in some of the homogeneous tests H2O2 was consumed faster. This effect was not observed with the other groundwater ions. Also, U dissolution rates were significantly lower in the carbonate experiments than in those with sulphate or silicate. The results suggest that a radical-controlled mechanism (similar to the Halpern–Smith-mechanism of dissolved U(IV) oxidation) takes place at the UO2 surface during dissolution. The hypothesis is supported by ESR measurements on hydroxyl radical scavenging by the carbonate ion.
Kinetics and electrochemical studies of uranium in acetate and formate media by cyclic voltammetry
Authors: Khan A. S. A. , Ahmed Riaz , Mirza M. L. 
Published: November 2007

SummaryThe cyclic voltammetric behavior of uranyl ion was investigated at hanging mercury drop electrode in perchlorate supporting electrolyte. The standard heterogeneous electron transfer rate constant “ks” for the reduction of uranyl ion in perchlorate medium was (2.74±0.03)×10−3cm s−1while in acetate and formate medium the value ofkswas (2.83±0.02)×10−3and (2.66±0.02)×10−3cm s−1, respectively. The effect of temperature on the values ofkswas investigated and thermodynamic constants ΔH*, ΔS* and ΔG298* were evaluated. The values of ΔH*, ΔS*; and ΔG298* were 8.06±0.03 kJ mol−1, −23.42±0.05 J mol−1K−1and 15.02±0.07 kJ mol−1in simple perchlorate medium and 3.67±0.02 kJ mol−1, −38.04±0.05 J mol−1K−1, and 15.01±0.03 kJ mol−1in acetate medium and 0.79±0.02 kJ mol−1, −48.24±0.04 J mol−1K−1and 15.17±0.02 kJ mol−1in formate medium, respectively. The thermodynamic data showed that the process of reduction of uranyl ion at hanging mercury drop electrode was endothermic and non-spontaneous. The stability constants of uranyl acetate and uranyl formate were calculated from an analysis of the shift in peak potential data. The logβ1and logβ2values for 1:1 and 1:2 uranyl acetate complexes were 2.67±0.04 and 4.71±0.01, respectively. The values of logβ1and logβ2of uranyl formate complex were 1.61±0.02 and 2.57±0.01, respectively, which are reported for the first time.
The removal of polonium-210 and lead-210 from copper process streams by molybdenum-doped sodium tungstate
Authors: Secomb Rodney J. , Griffith Christopher S. , Brown Susan A. , Luca Vittorio 
Published: November 2007

SummaryA molybdenum-doped sodium tungstate phase (Mo-HTB) and a porous, granular polyacrylonitrile composite variant (PAN-Mo-HTB) have been shown to effectively remove polonium-210 and lead-210 from concentrated sulphuric acid solutions (1–8 M) and a copper electrowinning electrolyte. Both forms of the exchanger were characterised by high polonium-210 and lead-210 distribution coefficients and very good selectivity for polonium-210 and lead-210 over divalent copper and iron.
Neue Parameter zur Analyse der Störungen eines Coriolis-Massemessers (New Parameters for Analysis of Distortions of a Coriolis Mass Flow Meter)
Authors: Goeke Johannes , Stock Marc , Steffensen Erk 
Published: November 2007

Alle Durchflussmesssysteme versagen bei der Messung von Zweiphasengemischen mit Gasen und Flüssigkeiten. Auch der Coriolis-Massemesser zeigt bereits bei kleinen Gasvolumina größer ein Prozent Abweichungen, die zu Ungenauigkeiten bei der Angabe des Massestroms und der Dichte führen.
In dieser Arbeit stellen wir die Ergebnisse einer spektralen Analyse der Schwingungen eines gestörten Coriolis-Massemessers vor. Ebenso zeigen wir Ergebnisse der Erregerströme und der Sensorspannungen für unterschiedliche Gasvolumina, Blasengrößen und Zusammensetzungen. Ebenso haben wir versucht, den Einfluss der Oberflächenspannung zu erfassen.
Zur Identifikation von Störungen durch die Gasphase werden Kennzahlen vorgeschlagen, die zur Korrektur der Störung beitragen können. Sie lassen sich darüber hinaus in ein Konzept einer vorbeugenden Wartung integrieren.
Impact of fetal growth restriction on body composition and hormonal status at birth in infants of small and appropriate weight for gestational age
Authors: Verkauskiene R , Beltrand J , Claris O , Chevenne D , Deghmoun S , Dorgeret S , Alison M , Gaucherand P , Sibony O , Lévy-Marchal C 
Published: November 2007

AbstractBackgroundFetal growth restriction (FGR) has been related to several health risks, which have been generally identified in small-for-gestational age (SGA) individuals.ObjectiveTo evaluate the impact of FGR on body composition and hormonal status in infants born either small- or appropriate-for-gestational age (AGA).MethodsFetal growth was assessed by ultrasound every 4 weeks from mid-gestation to birth in 248 high-risk pregnancies for SGA. Fetal growth velocity was calculated as change in the estimated fetal weight percentiles and FGR defined as its reduction by more than 20 percentiles from 22 gestational weeks to birth. Impact of FGR on body composition, cord insulin, IGF-I, IGF binding protein-3 (IGFBP-3), and cortisol concentrations was assessed in SGA and AGA newborns.ResultsGrowth-retarded AGA infants showed significantly reduced birth weight, ponderal index, percentage of fat mass, and bone mineral density when compared with AGA newborns with stable intrauterine growth. Cord IGF-I and IGFBP-3 concentrations were significantly decreased in growth-retarded infants in both SGA and AGA groups. Cord insulin concentration was significantly lower and cord cortisol significantly higher in AGA infants with FGR versus AGA newborns with stable intrauterine growth.After adjustment for gestational age and gender, birth weight was directly related to fetal growth velocity and cord IGF-I concentration. The variation in infant's adiposity was best explained by fetal growth velocity and cord insulin concentration.ConclusionsFGR affects body composition and hormonal parameters in newborns with birth weight within the normal range, suggesting these individuals could be at similar metabolic risks as SGA.
Central laboratory reassessment of IGF-I, IGF-binding protein-3, and GH serum concentrations measured at local treatment centers in growth-impaired children: implications for the agreement between outpatient screening and the results of somatotropic axis functional testing
Authors: Hauffa Berthold P , Lehmann Nils , Bettendorf Markus , Mehls Otto , Dörr Helmuth-Günther , Stahnke Nikolaus , Steinkamp Heinz , Said Elfriede , Ranke Michael B , _ _ 
Published: November 2007

AbstractBackgroundChildhood GH deficiency, suspected in the presence of decreased height velocity and short stature, is usually characterized by low IGF-I and IGF-binding protein-3 (IGFBP-3) serum concentrations and is conventionally confirmed by diminished GH peak responses to pharmacological stimuli.ObjectiveWe evaluated the agreement between different IGF-I (IGFBP-3) assays in predicting GH deficiency and tested whether variability between growth factor screening and pharmacological testing could be diminished by reassessment of growth factor and GH peak concentrations in a single laboratory.DesignUsing the Tuebingen IGF-I (IGFBP-3) RIA, 317 (321) sera from children evaluated for growth disorders in 19 centers were reanalyzed. In 103 children with insulin hypoglycemia and arginine tests, we evaluated how the association between the outcome of growth factor screening and functional testing would change if different assays were employed.ResultsLocally measured IGF-I correlated better than IGFBP-3 with the results of the central laboratory (Tuebingen) assay (slope of the regression curve 1.05; 95% confidence interval (95% CI) 1.01–1.1 versus 1.18; 95% CI 1.09–1.3). Agreement between local and central laboratory assays in predicting GH deficiency was better for IGF-I than for IGFBP-3 assays (κ=0.59 versus κ=0.47). The poor agreement between growth factor screening and GH pharmacological testing was not improved when hormone concentrations were remeasured in the central laboratory (κ local=−0.0031, central=0.12).ConclusionsIn children with impaired growth, growth factor screening reflects different aspects of GH insufficiency than does functional testing. Agreement between these approaches is poor and could not be improved by reduction of assay-related variability.