bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bibliometric and visualized analysis of posterior chamber phakic intraocular lens research between 2003 and 2023
Authors: Ning Jiliang , Zhang Qiaosi , Liang Wei , Zhang Rui , Xing Zequn , Jin Lin , Zhang Lijun 
Published: April 2024

IntroductionMyopia is causing a major public health concern, with its prevalence increasing globally. This study aimed to discuss posterior chamber phakic intraocular lens (pIOL) research publication trends and hotspots over the past 20 years.MethodsBibliometric analysis was performed using the Web Science Core Collection to investigate posterior-chamber pIOL research publication trends. The extracted records were analyzed, and a knowledge map was built using VOSviewer v.1.6.20. The analysis included visualizing the annual publication count, countries/regions distribution, international and institutional collaborations, author productivity, and journal contribution, in addition to identifying knowledge bases and hotspots. Burst keywords were extracted using CiteSpace v.6.1.R.ResultsIn total, 791 articles on posterior chamber pIOLs published between 2003 and 2023 were retrieved. China had the highest number of publications, whereas Japanese papers received the most citations. Fudan University had the highest number of publications, with articles from Kitasato University having the highest number of citations. Regarding individual research, Xingtao Zhou has published the most significant number of articles, and Shimizu Kimiya had the highest number of citations. The top productive/influential journal was ‘Journal of Cataract &amp; Refractive Surgery’. The top cited references primarily focused on reporting the clinical outcomes of implantable collamer lens (ICL) for individuals with moderate to high myopia. The keywords primarily formed four clusters: posterior chamber pIOL clinical outcomes for myopic astigmatism correction, posterior chamber pIOL implantation complications, ICL size selection and postoperative vault predictions, and postoperative visual quality following posterior chamber pIOL implantation.ConclusionThis study presents the first bibliometric analysis of research trends in posterior chamber pIOL over the past two decades. We investigated the current state and emerging trends of global collaboration and research focal points in this field, offering fresh insights and guidance for researchers.
Antibacterial efficacy of novel bismuth-silver nanoparticles synthesis on Staphylococcus aureus and Escherichia coli infection models
Authors: Castro-Valenzuela Beatriz Elena , Franco-Molina Moisés Armides , Zárate-Triviño Diana Ginette , Villarreal-Treviño Licet , Kawas Jorge R. , García-Coronado Paola Leonor , Sobrevilla-Hernández Gustavo , Rodríguez-Padilla Cristina 
Published: April 2024

IntroductionThe emergence of multi-drug-resistant bacteria is one of the main concerns in the health sector worldwide. The conventional strategies for treatment and prophylaxis against microbial infections include the use of antibiotics. However, these drugs are failing due to the increasing antimicrobial resistance. The unavailability of effective antibiotics highlights the need to discover effective alternatives to combat bacterial infections. One option is the use of metallic nanoparticles, which are toxic to some microorganisms due to their nanometric size.MethodsIn this study we (1) synthesize and characterize bismuth and silver nanoparticles, (2) evaluate the antibacterial activity of NPs against Staphylococcus aureus and Escherichia coli in several infection models (in vivo models: infected wound and sepsis and in vitro model: mastitis), and we (3) determine the cytotoxic effect on several cell lines representative of the skin tissue.Results and discussionWe obtained bimetallic nanoparticles of bismuth and silver in a stable aqueous solution from a single reaction by chemical synthesis. These nanoparticles show antibacterial activity on S. aureus and E. coli in vitro without cytotoxic effects on fibroblast, endothelial vascular, and mammary epithelium cell lines. In an infected-wound mice model, antibacterial effect was observed, without effect on in vitro mastitis and sepsis models.
Botulinum toxin A injection for post-stroke upper limb spasticity and rehabilitation practices from centers across Asian countries
Authors: Rosales Raymond L. , Chia Nicholas V. C. , Kumthornthip Witsanu , Goh Khean Jin , Mak Choon Soon , Kong Keng He , Ng Yee Sien , Chou Li Wei , Flordelis M. Jeanne , Do Thuy , Maisonobe Pascal , Li Leonard S. W. , Suputtitada Areerat 
Published: April 2024

PurposeDescribe real-life practice and outcomes in the management of post-stroke upper limb spasticity with botulinum toxin A (BoNT-A) in Asian settings.MethodsSubgroup analysis of a prospective, observational study (NCT01020500) of adult patients (≥18 years) with post-stroke upper limb spasticity presenting for routine spasticity management, including treatment with BoNT-A. The primary outcome was goal attainment as assessed using goal-attainment scaling (GAS). Patients baseline clinical characteristics and BoNT-A injection parameters are also described.ResultsOverall, 51 patients from Asia were enrolled. Rates of comorbid cognitive and emotional problems were relatively low. Patients tended to have more severe distal limb spasticity and to prioritize active over passive function goals. Most (94.1%) patients in the subgroup were treated with abobotulinumtoxinA. For these patients, the median total dose was 500 units, and the most frequently injected muscles were the biceps brachii (83.3%), flexor carpi radialis (72.9%), and flexor digitorum profundus (66.7%). Overall, 74.5% achieved their primary goal and the mean GAS T score after one treatment cycle was 56.0 ± 13.0, with a change from baseline of 20.9 ± 14.3 (p &lt; 0.001). The majority (96.1%) of Asian patients were rated as having improved.ConclusionIn the Asian treatment setting, BoNT-A demonstrated a clinically significant effect on goal attainment for the real-life management of upper limb spasticity following stroke.
Correlation between obstructive sleep apnea and hypoperfusion in patients with acute cerebral infarction
Authors: Zhou Yi , Jin Xiaomei , Liu Xiaorong , Tang Jiafan , Song Liyan , Zhu Yu , Zhai Wanqing , Wang Xianhui 
Published: April 2024

PurposeTo explore the relationship between obstructive sleep apnea (OSA) and hypoperfusion during ultra-early acute cerebral infarction.Patients and methodsData were retrospectively collected from patients admitted to our hospital with acute cerebral infarction between January 2020 and January 2022, who underwent comprehensive whole-brain computed tomography perfusion imaging and angiography examinations within 6 h of onset. The F-stroke software automatically assessed and obtained relevant data (Tmax). The patients underwent an initial screening for sleep apnea. Based on their Apnea-Hypopnea Index (AHI), patients were categorized into an AHI ≤15 (n = 22) or AHI &gt;15 (n = 25) group. The pairwise difference of the time-to-maximum of the residue function (Tmax) &gt; 6 s volume was compared, and the correlation between AHI, mean pulse oxygen saturation (SpO2), oxygen desaturation index (ODI), percentage of time with oxygen saturation &lt; 90% (T90%), and the Tmax &gt;6 s volume was analyzed.ResultsThe Tmax &gt;6 s volume in the AHI &gt; 15 group was significantly larger than that in the AHI ≤ 15 group [109 (62–157) vs. 59 (21–106) mL, p = 0.013]. Spearman’s correlation analysis revealed Tmax &gt;6 s volume was significantly correlated with AHI, mean SpO2, ODI, and T90% in the AHI &gt; 15 group, however, no significant correlations were observed in the AHI ≤ 15 group. Controlling for the site of occlusion and Multiphase CT angiography (mCTA) score, AHI (β = 0.919, p &lt; 0.001), mean SpO2 (β = −0.460, p = 0.031), ODI (β = 0.467, p = 0.032), and T90% (β =0.478, p = 0.026) remained associated with early hypoperfusion in the AHI &gt; 15 group.ConclusionIn patients with acute cerebral infarction and AHI &gt; 15, AHI, mean SpO2, ODI and T90% were associated with early hypoperfusion. However, no such relationship exists among patients with AHI ≤ 15.
Efficacy and safety of empiric treatment with omeprazole continuous infusion in critically ill children with gastrointestinal bleeding
Authors: Taher Khalid W. , Yaseen Rahaf , Alnan Mayas , Aburas Wejdan , Khalil Hala , Alabdulsalam Moath 
Published: April 2024

IntroductionGastrointestinal bleeding (GI) is a prevalent condition among pediatric patients, with a reported incidence of 6.4%, often severe enough to require admission to the pediatric intensive care unit (PICU). There are multiple therapies utilized in the management of GI bleeding in pediatrics, among which continuous intravenous (IV) infusion of omeprazole is used off-label without standard pediatric dosing recommendations. Reviewing the current literature reveals a lack of studies assessing the efficacy, safety, and appropriate dosing regimen of continuous omeprazole infusion in children with GI bleeding. This study aimed to evaluate the efficacy and safety of continuous IV omeprazole infusion in comparison to other therapeutic modalities in children.MethodsThis study is a single-center, retrospective chart review of children admitted to the PICU at King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia. The treatment group included pediatric patients with GI bleeding and receiving omeprazole IV continuous infusion over ≥24 h while the control group included pediatric patients with GI bleeding managed using other therapies. Primary outcomes were the efficacy of omeprazole continuous infusion in stopping GI bleeding, and PICU length of stay (LOS). Secondary outcomes included instances of rebleeding post- therapy discontinuation, transfusion requirements, and the safety of omeprazole continuous infusion.ResultsThe study included 81 critically ill pediatric patients, 22 of whom received continuous infusion omeprazole while 59 received other therapies. The results indicated that patients in the control group had a significantly shorter PICU LOS (8 vs. 18.5 days, p &lt; 0.001) and bleeding episode (4 vs. 10.5 days, p &lt; 0.001) than those in the treatment group. However, no significant differences were observed between the two groups regarding secondary outcomes. The treatment group had a significantly lower all-cause mortality rate during hospitalization compared to the control group (16 patients [72.7%] vs. 56 patients [94.9%], respectively, p = 0.005).ConclusionEmpirical use of omeprazole continuous intravenous infusion in children with GI bleeding was not favorable in terms of shortening PICU LOS and duration of GI bleeding. Our study results provide evidence supporting the safety and tolerability of omeprazole continuous infusion. Additional larger studies are necessary to determine the implication of such results.
Spatial heterogeneity of long-range dependence and self-similarity of global sea surface chlorophyll concentration with their environmental impact factors analysis
Authors: He Junyu , Gao Zekun , Jiang Yutong , Li Ming 
Published: April 2024

Understanding the long-range dependence and self-similarity of global sea surface chlorophyll concentration (SSCC) will enrich its characteristics description and analysis with global change patterns. The satellite SSCC products were collected from the European Space Agency during the period from 29 July 1998 to 31 December2020. After resampling the SSCC products into the spatial resolution of 1°, the missing values were interpolated by Bayesian maximum entropy with mean absolute error of cross validation equaling to 0.1295 mg/m3. Generalized Cauchy model was employed to quantitatively determine the long-range dependence and self-similarity of SSCC at a global scale by using the Hurst parameter and fractal dimension. Good fitted results were achieved with an averaged R2 of 0.9141 and a standard deviation of 0.0518 across the 32,281 spatial locations of the entire ocean; the averaged values of Hurst parameter and fractal dimension were 0.8667 and 1.2506, respectively, suggesting strong long-range dependence and weak self-similarity of SSCC in the entire oceans. Univariate and multivariate generalized addictive models (GAM) were introduced to depict the influence of sea surface height anomaly, sea surface salinity, sea surface temperature and sea surface wind on the Hurst parameter and fractal dimension of SSCC; and smaller mean absolute error were achieved for the GAM of Hurst parameter than that of fractal dimension. Sea surface height anomaly showed the strongest influence for the Hurst parameter than the other three factors, and sea surface wind depicted similar influence; the sea surface temperature owned opposite influence on Hurst parameter compared to sea surface salinity.
Histological analysis of the medial gastrocnemius muscle in young healthy children
Authors: Andries Anke , Deschrevel Jorieke , Maes Karen , De Beukelaer Nathalie , Corvelyn Marlies , Staut Lauraine , De Houwer Hannah , Costamagna Domiziana , Nijs Stefaan , Metsemakers Willem-Jan , Nijs Elga , Hens Greet , De Wachter Eva , Prinsen Sandra , Desloovere Kaat , Van Campenhout Anja , Gayan-Ramirez Ghislaine 
Published: April 2024

Introduction: Histological data on muscle fiber size and proportion in (very) young typically developing (TD) children is not well documented and data on capillarization and satellite cell content are also lacking.Aims: This study investigated the microscopic properties of the medial gastrocnemius muscle in growing TD children, grouped according to age and gender to provide normal reference values in healthy children.Methods: Microbiopsies of the medial gastrocnemius (MG) muscle were collected in 46 TD boys and girls aged 2–10 years subdivided into 4 age groups (2–4, 4–6, 6–8 and 8–10 years). Sections were immunostained to assess fiber type cross-sectional area (fCSA) and proportion, the number of satellite cells (SC), capillary to fiber ratio (C/F), capillary density for type I and II fiber (CFD), capillary domain, capillary-to-fiber perimeter exchange index (CFPE) and heterogeneity index. fCSA was normalized to fibula length2 and the coefficient of variation (CV) was calculated to reflect fCSA intrasubject variability.Results: Absolute fCSA of all fibers increased with age (r = 0.72, p &lt; 0.001) but more in boys (+112%, p &lt; 0.05) than in girls (+48%, p &gt; 0.05) Normalized fCSA, CV and fiber proportion did not differ between age groups and gender. C/F was strongly correlated with age in boys (r = 0.83, p &lt; 0.001), and to a lesser extent in girls (r = 0.37, p = 0.115), while other capillary parameters as well as the number of SC remained stable with increasing age in boys and girls.Discussion: This study provides reference values of histological measures in MG according to age in normally growing boys and girls. These data may be used as a reference to determine disease impact and efficacy of therapeutic approach on the muscle.
Sex-difference in the association between social drinking, structural brain aging and cognitive function in older individuals free of cognitive impairment
Authors: Abulseoud Osama A. , Caparelli Elisabeth C. , Krell‐Roesch Janina , Geda Yonas E. , Ross Thomas J. , Yang Yihong 
Published: April 2024

BackgroundWe investigated a potential sex difference in the relationship between alcohol consumption, brain age gap and cognitive function in older adults without cognitive impairment from the population-based Mayo Clinic Study of Aging.MethodsSelf-reported alcohol consumption was collected using the food-frequency questionnaire. A battery of cognitive testing assessed performance in four different domains: attention, memory, language, and visuospatial. Brain magnetic resonance imaging (MRI) was conducted using 3-T scanners (Signa; GE Healthcare). Brain age was estimated using the Brain-Age Regression Analysis and Computational Utility Software (BARACUS). We calculated the brain age gap as the difference between predicted brain age and chronological age.ResultsThe sample consisted of 269 participants [55% men (n=148) and 45% women (n=121) with a mean age of 79.2 ± 4.6 and 79.5 ± 4.7 years respectively]. Women had significantly better performance compared to men in memory, (1.12 ± 0.87 vs 0.57 ± 0.89, P&lt;0.0001) language (0.66 ± 0.8 vs 0.33 ± 0.72, P=0.0006) and attention (0.79 ± 0.87 vs 0.39 ± 0.83, P=0.0002) z-scores. Men scored higher in visuospatial skills (0.71 ± 0.91 vs 0.44 ± 0.90, P=0.016). Compared to participants who reported zero alcohol drinking (n=121), those who reported alcohol consumption over the year prior to study enrollment (n=148) scored significantly higher in all four cognitive domains [memory: F3,268 = 5.257, P=0.002, Language: F3,258 = 12.047, P&lt;0.001, Attention: F3,260 = 22.036, P&lt;0.001, and Visuospatial: F3,261 = 9.326, P&lt;0.001] after correcting for age and years of education. In addition, we found a significant positive correlation between alcohol consumption and the brain age gap (P=0.03). Post hoc regression analysis for each sex with language z-score revealed a significant negative correlation between brain age gap and language z-scores in women only (P=0.008).ConclusionAmong older adults who report alcohol drinking, there is a positive association between higher average daily alcohol consumption and accelerated brain aging despite the fact that drinkers had better cognitive performance compared to zero drinkers. In women only, accelerated brain aging is associated with worse performance in language cognitive domain. Older adult women seem to be vulnerable to the negative effects of alcohol on brain structure and on certain cognitive functions.
Caring for a child with cancer during COVID-19 pandemic: an assessment of the parents’ perception and stress level
Authors: Nawi Muhamad Aizat , Lau Sie Chong Doris , Chin Shi Tying , Teh Kok Hoi , Ho Lee Sue Betty , Alias Hamidah 
Published: April 2024

BackgroundThe emergence of COVID-19 pandemic has led to heightened fear and uncertainty among parents of children with cancer. This study was conducted to evaluate the parental perceptions toward effects of COVID-19 infection to children with cancer, determine their stress level and factors contributing to high stress level during the pandemic.MethodsThis cross-sectional study was conducted in three paediatric oncology centres in Malaysia from September 2020 until December 2022. A total of 167 parents were recruited. Parents completed a set of questionnaires to assess their perception on effect of COVID-19 infection to children with cancer and COVID Stress Scale (CSS) to assess the parents’ stress level.ResultsPatients’ mean age at study entry was 8.75 years (SD 4.38). Ninety-one (54.5%) patients were still on active treatment. More than 80% of the parents obtained information regarding COVID-19 infection from mass media and social networking. Fear of their children contracting COVID-19 infection was high especially among patients who were still on treatment. Forty-nine (29.3%) parents were significantly affected by the pandemic leading to loss of job or monthly income. Twenty-nine (17.4%) patients required treatment modification during the pandemic. The median total score for CSS was 78.0 (IQR 25th 64.0; 75th 95.0). Ninety-one (54.5%) respondents were very/extremely stressed based on the CSS scores. Components with high scores were xenophobia (median score 18.0; IQR 25th 13.0, 75th 22.0), fear of danger (median score 17.0; IQR 25th 14.0, 75th 20.0) and contamination fears (median score 16.0; IQR 25th 12.0, 75th 19.0). Lower household income was associated with higher stress level (p = 0.006).ConclusionOur study demonstrated high awareness regarding risk of COVID-19 infection among parents of oncology children. Half of the parents had high stress level, with low household income identified as a factor associated with high stress level.
Analysis of the influence of educational level on the nutritional status and lifestyle habits of the young Spanish population
Authors: Sandri Elena , Pardo Juan , Cantín Larumbe Eva , Cerdá Olmedo Germán , Falcó Antonio 
Published: April 2024

AimThis study aims to analyze some nutrition and health habits of young people and the impact of educational attainment on health.MethodsAn observational, descriptive, and cross-sectional study was carried out using surveys. Using non-probabilistic snowball sampling, a previously validated questionnaire was disseminated through networks, collecting a sample of 9,681 people between 18 and 30  years old. Comparative analyses between groups were obtained by clustering and the corresponding statistical tests.ResultsThe results showed how young people with higher education generally have a lower BMI, a higher healthy nutrition index, less frequent consumption of sugary drinks, and less smoking than their peers with basic education. These healthier habits are reflected in the higher self-perceived health status of the higher-educated group. While for all the educational levels analyzed, the minutes of physical activity practice are above the 150 min recommended by the WHO.ConclusionOur findings suggest that young people’s education level is of fundamental importance for health, particularly for nutritional habits. In general, the lifestyle habits of the young Spanish population are healthy, but there is a need for improvement in those aspects related to nutrition and food.
Discussion on the recruitment strategy for apheresis platelet donors in Chongqing during a public health emergency*
Authors: Cheng Ying , Xie Chengbing , Tian Yunbo , Wang Fang , Liu Xingchen , Cheng Danfeng 
Published: April 2024

ObjectiveThis study aimed to analyze the population characteristics of apheresis platelet donors in Chongqing Province and provide a scientific basis for the development of precise and efficient recruitment strategies. The ultimate goal is to increase the number of regular platelet donors in preparation for public health emergencies.MethodsThis study involved 53,089 blood donors who donated apheresis platelets to the Chongqing Blood Center from 2020 to 2022. Data regarding age, sex, blood type, education level, occupation, and frequency of blood donation were collected and analyzed to identify factors influencing platelet donation.ResultsBetween 2020 and 2022, the majority of apheresis platelet donors in Chongqing were aged 25–35 years, with a male-to-female ratio of 2.6:1. The ABO blood group distribution was O &gt; A &gt; B &gt; AB. The apheresis platelet donors mainly consisted of college students, and the donors who had donated only once accounted for the greatest proportion.ConclusionBased on the population characteristics of apheresis platelet donors in Chongqing, blood collection and supply organizations must refine emergency blood collection and supply plans during public health emergencies. This study underscores the importance of developing precise and efficient recruitment strategies for apheresis platelet donors and expanding the pool of regular apheresis platelet donors. These measures are essential to ensure the timely, safe, and effective use of clinical blood resources during public health emergencies.