bluuebunny/crossref_metadata_2025_split huggingface dataset:
Breast cancer survival among orientals and whites living in the United States
Authors: Natarajan Nachimuthu , Nemoto David , Nemoto Takuma , Mettlin Curtis 
Published: February 2007

AbstractData from the 1982 breast cancer survey of the American College of Surgeons were used to study the survival differences between Oriental and white women. Oriental women were significantly younger than white women. Oriental women were reported with a slightly higher percent of localized breast tumors (59.2% vs. 53.8%) and a slightly higher percent with negative nodes (60.3% vs. 56.2%) compared with whites. Oriental women in the United States have a higher 5‐year survival rate compared to whites. Multivariate analyses taking into account differences in age, stage of disease, and histology did not alter the finding of a significant difference in survival experiences.
Implantofix vascular access system: An experience with 19 patients
Authors: Alpeter David M. , Welling Richard E. , Alexander Saba K. , Mahalingam Kris , Arbaugh James 
Published: February 2007

AbstractThe use of implantable vascular access devices has increased rapidly in recent years. We have placed the new Implantofix Implantable Drug Delivery System 7500 in 19 patients. The patients reported only minor discomfort. The majority of the nurses found the Implantofix port easier to access than other ports, and some reported less swelling and soreness at the port site. Some of the physicians had difficulty visualizing the radiopaque catheter on X‐ray; Burron is currently developing a more radiopaque system.The Implantofix system offers several important benefits. Its compact size assures minimal discomfort for the patient. A new peel‐away sheath offers a choice of insertion methods. The system is particularly economical because it can be implanted in an ambulatory care facility or an outpatient surgery room equipped with fluoroscopic capabilities.
Effects of rat platelet extracts and human platelet‐derived growth factor on megakaryocytopoiesis in vitro
Authors: Uyar Ruhi , Cooper George W. , Hou Xiao Ping 
Published: February 2007

AbstractAn improved plasma clot culture system was developed for the culture of rat megakaryocyte colonies in vitro. Greater stimulation of megakaryocyte colony growth was provided when both serum and plasma were added to the culture medium than when plasma was added alone. Freeze‐thawed extracts prepared from 900 × 106 platelets/ml saline and also 9 ng/ml of human platelet‐derived growth factor (PDGF) caused maximum increases over the controls of 71% and 42%, respectively, in the numbers of megakaryocyte colonies. The increase in the numbers of megakaryocyte colonies induced by platelet extracts and by PDGF implied that substance(s) released by platelets might play an important role in the control of megakaryocytopoiesis.
Tumor tissue is more sensitive to mitomycin C, carboquone, and aclacinomycin A than is adjacent normal tissue in vitro
Authors: Maehara Yoshihiko , Kusumoto Hiroki , Kusumoto Tetsuya , Anai Hideaki , Sugimachi Keizo 
Published: February 2007

AbstractIn tissues obtained from patients undergoing gastrectomy or colectomy, sensitivity to mitomycin C (MMC), carboquone (CQ), and aclacinomycin A (ACR) was examined in 20 tumors (15 gastric, 5 colorectal) and in the adjacent normal mucosal tissues, using the in vitro succinate dehydrogenase inhibition test. The succinate dehydrogenase (SD) activity decreased to a greater extent in the tumor tissues than in adjacent normal tissues, at rates of 80% for MMC, 80% for CQ, and 90% for ACR. There were no correlations between SD activities of tumor and adjacent normal tissue, r = 0.157 for MMC, r = 0.435 for CQ, and r = 0.375 for ACR. Normal tissues were sensitive to MMC in 25 % of cases sensitive to MMC in the tumor tissues, 46% for CQ, and 38% for ACR. These results show that the antitumor effects of MMC, CQ, and ACR are relatively specific for tumor tissues and that the assay of chemosensitivity of normal tissues is meaningful for predicting the toxic effects of antitumor drugs on these tissues.
Aggressive chemotherapy in endodermal sinus tumor
Authors: Athanikar Nita , Saikia Japan K. , Ramkrishnan Gopal , Nair Chandrika N. , Nadkarni Kanchan S. , Advani Suresh H. 
Published: February 2007

AbstractTwenty‐eight patients with pure or predominantly endodermal sinus tumor were studied for their clinical behavior, relation with serum α‐fetoprotein (AFP), and response to intensive postoperative combination chemother apy. Eight percent of the patients were younger than 20 years of age. One patient was a pseudohermaphrodite. Serum AFP was estimated in 17 patients and was elevated in all. Seven patients were treated with adjuvant chemotherapy following surgery with a cisplatin‐containing combination. Five patients (71%) are alive and continue to remain free of disease, with a median survival of 28 months after treatment and an overall median survival of 34 months. Two patients treated with adjuvant chemotherapy experienced early recurrence of the disease, which was detected with a rise in serum AFP before the clinical manifestation of recurrence.
Controlled clinical trial of adjuvant immunotherapy with BCG and neuraminidase‐treated autologous tumour cells in large bowel cancer
Authors: Gray B. N. , Walker C. , Andrewartha L. , Freeman S. , Bennett R. C. 
Published: February 2007

AbstractA controlled, randomised clinical trial of immunotherapy was performed in 301 patients with stage B or C colorectal cancer. The immunotherapy treatment consisted of 18 vaccinations over a 2 year period following surgery with a combination of BCG given by scarification plus subcutaneous injection of Vibrio cholera neuraminidase (VCN)‐modified autologous tumour cells. Five year follow‐up has now been completed in all patients. The immunotherapy did not alter either the disease‐free interval or the overall survival of patients in comparison with a control group of patients not receiving immunotherapy.
Leiomyosarcomas of the extremities
Authors: Neugut Alfred L. , Sordillo Peter P. 
Published: February 2007

AbstractLeiomyosarcomas are uncommon malignant neoplasms that rarely arise in the extremities. We report on the clinical characteristics of 17 cases seen at the Memorial Sloan‐Kettering Cancer Center over a 32 year period. Most neoplasms occurred in the lower extremities, and most of the tumors recurred after surgery alone, with several late recurrences. The overall prognosis was grim, with a median survival of 24 months. More aggressive multidisciplinary approaches to this disease are warranted.
Intraoperative antegrade irrigation in complicated left‐sided colonic cancer
Authors: Meijer S. , Hoitsma H. F. W. , Van Loenhout R. M. 
Published: February 2007

AbstractEmergency one‐stage surgery for acute, complicated, left‐sided colonic cancer can be performed because of intraoperative antegrade irrigation of the large intestine. This procedure was performed in 17 patients: 15 patients with an obstructive, left‐sided cancer and two patients with a perforated carcinoma. The age distribution ranged between 57 and 92 years. There were two postoperative septic complications: a small wound abscess and a partial abdominal wall dehiscence. One patient died because of massive upper gastrointestinal bleeding. This method permits the creation of a primary anastomosis in the left colon, obviating the necessity of a coeco‐ or colostomy, preternatural anus, or an extensive right‐sided hemicolectomy. Several surgical interventions are avoided, resulting in a decrease of mortality, morbidity, duration of hospital stay, and costs. Moreover, intraoperative irrigation could be an attractive alternative for the usual preoperative mechanical bowel preparation, which is especially burdensome in elderly patients.
Pulmonary embolism and cancer: Predisposition to venous thrombosis and embolism as a paraneoplastic syndrome
Authors: Sons Hans U. 
Published: February 2007

AbstractIn patients with a malignant primary disease the risk of thromboembolic complication is demonstrably increased. This is undoubtedly attributable to a whole range of factors (multifactorial etiology) which are highlighted in the present synoptic study. In addition to local influences from the tumor, a particular role appears to be played by an increased aggregation of thrombocytes, various tumor cell products, polyglobulism, hypercalcemia, increased release of thrombocinase, microthrombotic embolization, and a decrease in antithrombin III.
Percutaneous superfine‐needle aspiration biopsy of intrathoracic lesions guided by simulator
Authors: Liu Cuanc‐Sen , Wu Yi‐Long , Zeng Cang‐Guang , Yang Ming‐Tian , Cai Yong‐Hui , Rong Tie‐Hua , Huang Zhi‐Fan , Liang Xiao‐Man 
Published: February 2007

AbstractThe result of percutaneous superfine‐needle aspiration biopsy in 100 patients with intrathoracic lesions guided by simulator is reported. The success rate of aspiration biopsy was 94%, and no major complication was observed. The method of localization by simulator had advantages such as accuracy in localization, no limitation of mass size and site, and a high rate of puncture success. Cell smears obtained by superfine needle were similar to those obtained by fine‐ or large‐bore needles, but fewer complications were encountered. This is a useful technique that can provide early cytological diagnosis, especially for the peripheral type of pulmonary mass.
Palliative and curative surgical therapy of malignant stenoses of the esophagus and cardia
Authors: Sons H. U. , Streicher H. J. 
Published: February 2007

AbstractBetween January 1967 and July 1986, 171 patients with malignant stenosis of the esophagus and cardia were subjected to curative or palliative surgical treatment. Specifically, there were 84 primary esophageal carcinomas, 5 cases of malignant esophageal stenosis caused by an extraesophageal malignant tumor (inter alia bronchial carcinoma), and 82 primary carcinomas of the cardia. The average age of the patients as a whole was 63.7 years, and the sex ratio (male:female) was 4.0:1. In 18 esophageal carcinoma patients and 21 patients with carcinoma of the cardia curative resection was possible, but in 132 patients merely palliative surgery was performed, most frequently esophageal intubation and gastrostomy. The specific operations with a curative objective performed upon the esophageal carcinoma patients were abdominothoracic esophageal resection with upward displacement of the stomach (n = 16) or interposition of a colonic segment (n = 2), whereas in the patients with carcinoma of the cardia, proximal resection was performed in 13 cases, either subtotally or as a cardiofundectomy, and total gastrectomy in 8 cases. For the subsequent reconstruction of the passage the interposition of a jejunal segment was most frequently used. The clinical mortality for the curative resections was 33% for the 18 esophageal carcinoma patients and 9.5% for the 20 patients with carcinoma of the cardia. The long‐term survival rates are depressing: of the patients who underwent curative resection 47.6% were still alive after one year, 28.6% after 2 years and 14.3% after 5 years. Of the patients treated only palliatively on account of an already advanced stage of the tumor, 91.5% died within the first year; only 4.9% of patients from this group were still alive after 2 years.
Radical nerve‐sparing prostatectomy: The first 30 patients treated with epidural anesthesia
Authors: Drago Joseph R. , Nesbitt John A. , Badalament Robert A. 
Published: February 2007

AbstractFrom August 1985 to January 1987, 30 patients were treated with radical nerve‐sparing prostatectomy with epidural anesthesia. Transrectal ultrasound evaluation was available for the vast majority of these patients. Utilizing the anatomic techniques of early dorsal vein ligation, hypogastric artery control, and epidural anesthesia, blood loss was kept to a minimum, with 22 patients requiring no transfusions in this series. In addition, with the use of ultrasound, PSA (prostatic‐specific antigen) determination, and pelvic CAT scan, 22 of the 30 patients (75%) had organconfined disease. Twenty patients were potent preoperative and 14 are potent postoperative, for a potency rate of 70%.
Use of a totally implantable drug delivery system in a university‐affiliated community hospital
Authors: Smith‐Behn James , Ghani Abdul 
Published: February 2007

AbstractWe reviewed our experience at the Western Reserve Care System with totally implantable drug delivery systems (IDDS) in cancer patients with vascular access problems. Fifty‐one ports were placed in 50 patients. Forty‐nine of the IDDS were placed under local anesthesia. One patient developed a hemothorax during placement. Two catheters were removed because of infection. Two catheters found to be occluded responded to flushing with streptokinase. All catheters remained functional up to the time of treatment completion or of the patient's death. The low morbidity and high success rates of IDDS should encourage placement early in the course of chemotherapy.
Limitations of flow cytometric DNA analysis for the diagnosis of bladder cancer
Authors: Boileau Michel A. , Swartz Douglas , Schmidt Karmen L. , Schmidt Waldemar A. 
Published: February 2007

AbstractFlow cytometric analysis was done on exfoliated urothelial cells from 11 control patients and 31 patients with transitional cell carcinoma: 9 grade I, 11 grade II, and 11 grade III. The determination of aneuploidy by DNA analysis did not provide identification of low‐grade tumor cells. Other flow cytometric parameters of cellular change such as cell size, nuclear size, nuclear/cytoplasmic ratio, or cell refractivity may provide better identification of low‐grade lesions.
Nutritional effects of postgastrectomy reconstruction: A clinical evaluation
Authors: Zelnick Ronald , Auguste Louis‐Joseph , Wise Leslie 
Published: February 2007

AbstractTo evaluate the nutritional benefits of a jejunal pouch vs. esophagojejunostomy following total gastrectomy, we reviewed 24 consecutive cases of total gastrectomy: 14 males and 10 females, 39 to 85 years of age (mean 66.6 y.) undergoing 9 jejunal pouches (JP) and 15 Roux‐en‐Y esophagojejunostomy (EJ). Indications for surgery included 15 adenocarcinomas, 3 lymphomas, 1 leiomyoma, and 5 hemorrhagic gastritis. The operative mortality was 12.5%. One JP patient was lost to follow‐up. The mean survival for EJ was 13.3 months and for JP 36 months. Total gastrectomy resulted in persistent weight loss and hypoalbuminemia, and the creation of a jejunal pouch did not seem to improve significantly the nutritional status following total gastrectomy.
Optimal debulking following chemotherapy of advanced‐stage epithelial ovarian carcinoma
Authors: Piura Benjamin , Glezerman Marek 
Published: February 2007

AbstractWe reviewed the records of 110 consecutive patients with advanced‐stage epithelial ovarian carcinoma treated at the Soroka Medical Center, Beer‐Sheva, Israel, from 1961‐1987. Twenty patients (18.1%) had optimal debulking at initial laparotomy, 30 patients (27.2%) had nonoptimal debulking at initial laparotomy, 20 patients (18.1%) had an “inoperable” disease at initial laparotomy, and 40 patients (36.3%) had such poorly written records that no information about the degree of resectability at initial laparotomy could be obtained. Four patients, in whom the residual tumor left at initial laparotomy had responded to chemotherapy, had a second laparotomy. In all four patients optimal debulking surgery at second laparotomy was easy to perform and was successful. The value of a second laparotomy after a few cycles of chemotherapy in order to optimally debulk the residual tumor left at initial laparotomy is discussed. It is concluded that a second attempt of debulking surgery after chemotherapy has a respectable place in the management of patients with advanced‐state epithelial ovarian carcinoma, but further research is needed.
Factitious microcalcifications in breast biopsy material: Laboratory‐induced error by use of tattoo powder for specimen mammography
Authors: Lager Donna J. , O'Connor John C. , Robinson Robert A. , Brown Robert C. , Urdaneta Luis F. 
Published: February 2007

AbstractA xeromammogram led to the surgical excision of a calcified breast lesion on a 66‐year‐old female. Before specimen mammography was performed, the excised tissue was oriented with tattoo pigment. The specimen mammogram then revealed multiple calcifications caused by unsuspected radio‐opaque material in the tattoo pigment, and the original calcifications were obscured. This case demonstrates the hazards involved utilizing tattoo powders for orienting xeromammographically discovered specimens.
Inflammatory pseudotumor of the liver
Authors: Standiford S. B. , Sobel H. , Dasmahapatra K. S. 
Published: February 2007

AbstractInflammatory pseudotumors (plasma cell granulomas) are localized lesions consisting of a fibrous stroma, chronic inflammatory infiltrate with a predominance of plasma cells, and an absence of anaplasia, which can mimic malignant disease by their gross appearance. Reported in many sites, they are most frequently described in the lung. Twelve cases involving the liver and biliary tract have previously been reported. Here, a 77‐year‐old man who presented with fever and malaise was found to have a lesion in the left lobe of the liver, which, on exploration, was found to be an inflammatory pseudotumor. This patient, and each of those previously reported, has recovered uneventfully. Because of the benign course of this lesion, hepatectomy should be considered only in those instances in which the mass effect of the lesion is producing symptoms or in those cases in which a firm histologic diagnosis cannot be made preoperatively or by frozen section intraoperatively.
Efficacy of intravesical mitomycin C in the treatment of superficial transitional cell carcinoma of the urinary bladder
Authors: Pavlotsky Abraham , Eidelman Abraham , Barak Frida , Alon Haim , Horn Yoav 
Published: February 2007

AbstractWe treated 47 patients with recurrent transitional cell carcinoma of the bladder with intravesical chemotherapy. Twenty milligrams of mitomycin C per treatment was introduced 7 days after transurethral resection (TUR) or diagnostic cystoscopy, and was repeated at 2‐week intervals for five times followed again by cystoscopy. Two more similar courses were administered for a total of 36 weeks. Clinical data revealed no toxicity‐related symptoms. Cystoscopic follow‐up showed a gradual decline in the presence of tumor to a complete response rate of 87.1% at 36 weeks. Thirteen patients who were previously treatment failures with other drugs responded to mitomycin C.
Treatment of breast cancer in women older than 70 years
Authors: Svastics Egon , Sulyok Zoltan , Besznyak Istvan 
Published: February 2007

AbstractDo age, associated diseases, general state, or the stage of tumor determine the operability of breast cancer in the elderly? Risk factors are studied on the basis of data on 465 patients over 70 years of age who had breast cancer surgery between 1977 and 1986. Operative mortality of patients is analyzed, and according to the results, the outcome of the surgery is mainly influenced by patients' performance status (Karnofsky/Zubrod index) and stage of disease and not by the associated diseases or patient age.
Survival and complications after radical surgery for carcinoma of the rectum
Authors: Cunsolo A. , Bragaglia R. B. , Petrucci C. , Poggioli G. , Gozzetti G. 
Published: February 2007

AbstractThe results of 164 abdominoperineal resections and 87 anterior resections carried out between 1972 and 1985 for cancer of the rectum were reviewed, assessed, and compared. The problems with anterior resection included a 1.1% hospital mortality and a 5.4% anastomotic failure rate in the 73 manual sutures and 28.5% in the 14 mechanical sutures; recurrence rate was 15.4% and the global 5‐year‐survival was 62%. There was no mortality in the Miles series; the recurrence rate was 4.8% and the 5‐year‐survival rate was 53.5%. Urogenital complications after Miles were found in 86.9%: urinary alone 10.8%, sexual alone 19.5%, both 56.5%.
Lung metastases after curative or noncurative irradiation of microscopic primary melanomas
Authors: Nathanson S. David , Westrick Patricia , Anaya Patricia , Hetzel Fred W. , Lee Min 
Published: February 2007

AbstractMelanomas growing in the feet of syngeneic C57BL/6 mice were treated with a single dose of X‐irradiation. After doses of 0, 3.75, 7.5, 10, 20, or 30 Gy the tumor‐bearing limb was amputated at tumor sizes 1, 2, 3, 4, or 5 mm. After doses of 40, 50, 62.5, or 72.5 Gy, progressive tumor growth did not occur, and amputation of tumor‐bearing limbs was done when controls were 1, 2, 3, 4, or 5 mm in size. Eighteen days after amputation the mice were killed, and pulmonary metastases were documented at autopsy. None of the mice developed pulmonary metastases after curative irradiation of the primary foot tumor. After subcurative irradiation there was a significant increase (P < .003) in pulmonary metastases. The size of the primary melanoma is important in the prediction of these metastases. In this model melanomas can be cured by an adequate dose of irradiation, but in those not cured the incidence of lung metastases is increased. The impact of this biologic phenomenon on survival is unclear.
Hospital costs, cancer patients, and surgical diagnostic related groups
Authors: Muñoz Eric , Chalfin Donald , Sterman Harris , Goldstein Jonathan , Margolis Irving , Wise Leslie 
Published: February 2007

AbstractThis study of 4,359 Medicare patients in 107 noncancer stratified surgical Diagnostic Related Groups (DRGs) tested the hypothesis that patients with a diagnosis of a malignancy (i.e., cancer) in these DRGs would have higher resource utilization than patients without a diagnosis of a malignancy (i.e., noncancer) in these same surgical DRGs. The 1,008 cancer patients had 3.2 times the financial loss ($1,617 per patient vs. $510 per patient) compared to the 3,35 1 noncancer patients (P < .05). Patients with cancer had a greater percentage of outliers, more diagnosis (P < .0001) and procedures (P < .0001) per patient, and a higher mortality (P < .01) than patients without cancer. These findings raise the question of the equity of DRG payment for patients with cancer in many surgical DRGs. Financial disincentives to treat certain groups of Medicare cancer patients at our hospital may affect both their access and quality of care in the future.
Intermediate results and functional evaluation of limb‐salvage surgery for osteosarcoma: An intergroup study in Japan
Authors: Tomita Katsuro , Tsuchiya Hiroyukl 
Published: February 2007

AbstractThis is a 2‐7‐year follow‐up report by 21 institutes in Japan concerning limb‐salvage surgery for osteosarcoma. Between 1980 and 1985, 248 patients with osteosarcoma were treated, and 105 patients had limb‐salvage surgery. The percentage of cases treated by limb‐salvage surgery increased with each year. The cumulative survival rate was 71% at 5 years in the limb‐salvage group, and in the amputation group it was 46%; this indicates that cases for limb‐salvage surgery were carefully evaluated for this procedure. In limb‐salvage patients, tumor resection was classified according to the surgical margin as intralesional excision, marginal excision, wide‐with‐marginal resection, wide resection, and radical resection. Wide resection was performed in most cases as the method of choice. Local recurrence was seen in 13 cases (12%). The overall functional evaluations by Enneking's system showed that the number of results rated excellent or good was relatively high in the early follow‐up period, but this decreased later on, and cases rated fair or poor increased as the years passed. This was mainly due to postsurgical complications (44 cases). We identify a few problems in the functional evaluation system used now and suggest a reform of the system, so that physical and mental factors would evaluated separately.