bluuebunny/crossref_metadata_2025_split huggingface dataset:
CXCR4/SDF‐1 system modulates development of GnRH‐1 neurons and the olfactory system
Authors: Toba Yoko , Tiong Jean D. , Ma Qing , Wray Susan 
Published: January 2008

AbstractStromal cell‐derived factor 1 (SDF‐1) and its receptor CXCR4 influence neuronal migration and have been identified in nasal regions. Gonadotropin releasing hormone‐1 (GnRH‐1) neurons migrate from nasal regions into the developing forebrain, where postnatally they control reproduction. This study examined the role of SDF‐1/CXCR4 in development of the GnRH‐1/olfactory systems. Migrating GnRH‐1 neurons were CXCR4 immunopositive as were the fibers along which they migrate. SDF‐1 transcripts were detected in olfactory epithelium and vomeronasal organ, while SDF‐1 immunoreactivity highlighted the GnRH‐1 migratory pathway. CXCR4‐deficient mice showed a decrease in GnRH‐1 cells at the nasal forebrain junction and in brain, but the overall migratory pathway remained intact, no ectopic GnRH‐1 cells were detected and olfactory axons reached the olfactory bulb. To further characterize the influence of SDF‐1/CXCR4 in the GnRH‐1 system, nasal explants were used. CXCR4 expression in vitro was similar to that in vivo. SDF‐1 was detected in a dorsal midline cell cluster as well as in migrating GnRH‐1 cells. Treatment of explants with bicyclam AMD3100, a CXCR4 antagonist, attenuated GnRH‐1 neuronal migration and sensory axon outgrowth. Moreover, the number of GnRH‐1 neurons in the explant periphery was reduced. The effects were blocked by coincubation with SDF‐1. Removal of midline SDF‐1 cells did not alter directional outgrowth of olfactory axons. These results indicate that SDF‐1/CXCR4 signaling in not necessary for olfactory axon guidance but rather influences sensory axon extension and GnRH‐1 neuronal migration, and maintains GnRH‐1 neuronal expression as the cells move away from nasal pit regions. © 2008 Wiley Periodicals, Inc. Develop Neurobiol 2008
Developmental analysis of Lingo‐1/Lern1 protein expression in the mouse brain: Interaction of its intracellular domain with Myt1l
Authors: Llorens Franc , Gil Vanesa , Iraola Susana , Carim‐Todd Laura , Martí Eulàlia , Estivill Xavier , Soriano Eduardo , del Rio José Antonio , Sumoy Lauro 
Published: January 2008

AbstractLingo‐1 (also known as Lern1) is a component of the Nogo receptor complex that mediates intracellular signaling in response to myelin associated inhibitors (MAIs): NogoA, MAG, and Omgp. Signaling through Nogo receptor extends to more than its well known role in preventing axon regeneration after lesion in the CNS, being implicated in neuronal functional maturation. Using Lingo‐1‐deficient mice, it has been demonstrated that Lingo‐1 plays relevant roles in oligodendrocyte differentiation during brain development, and that treatment with Lingo‐1 antagonists can improve axon regeneration after lesion in adult mice by decreasing MAI mediated signaling. However, a detailed description of the pattern of expression of Lingo‐1 protein in correlation with the other partners of Nogo receptor is missing. Here, we show that components of the Nogo receptor complex, Lingo‐1, NgR1, p75, and TROY coexist in mouse brain in a defined time window only at later postnatal stages. We have also determined the Lingo‐1 distribution showing expression in particular subsets of neurons, but not in myelinating mature oligodendrocytes. Surprisingly, Lingo‐1 is expressed at early developmental stages without NgR1, which supports the notion that Lingo‐1 may participate in other activities in developing neurons different from oligodendrocyte maturation or axon extension inhibition in the adult. Finally, we propose that the intracellular domain of Lingo‐1 contributes to signaling and show that it interacts with the postmitotic neuronal specific zinc finger protein Myt1l, suggesting that Lingo‐1 may regulate Myt1l transcription factor activity by affecting its subcellular localization. © 2008 Wiley Periodicals, Inc. Develop Neurobiol 2008
Synthesis, Structure, and Magnetic Properties of Three Chiral Sodium‐Centered Polynuclear Copper(II) Clusters with L‐Alanine
Authors: Hu Sheng‐Min , Xiang Sheng‐Chang , Zhang Jian‐Jun , Sheng Tian‐Lu , Fu Rui‐Biao , Wu Xin‐Tao 
Published: January 2008

AbstractBy controlling the reactant proportion, three sodium‐centered polynuclear octahedral copper(II)–amino acid clusters, [Na⊂{Cu6(Ala)8(H2O)(ClO4)}]·4ClO4·4H2O (1), Na[Na⊂{Cu6(Ala)8(ClO4)}]2·9ClO4·8H2O (2), and [Na⊂{Cu5(Ala)6(H2O)3}]n·5n(ClO4)·3n(H2O) (3) (Ala = L‐alanine), were synthesized. The structures were characterized by X‐ray structure analysis. The structure of 1 can be described as an octahedron formed with six copper atoms in which four Cu(Ala)2 ligands bridge two axial copper ions and capture one Na+ in the center of the cage and that of 2 as an octahedral dimer that is linked by two carboxylate oxygen atoms. Complex 3 is a chain composed of incomplete octahedron [NaCu5] units linked together by two carboxylate oxygen atoms. The magnetic susceptibility measurements indicate that all three clusters are ferromagnetic overall, although the intercluster interactions may be antiferromagnetic. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Impact of depressive symptoms on the rate of progression to dementia in patients affected by mild cognitive impairment. The Italian Longitudinal Study on Aging
Authors: Panza Francesco , Capurso Cristiano , D'Introno Alessia , Colacicco Anna M. , Zenzola Annalisa , Menga Roberta , Pistoia Giuseppe , Santamato Andrea , Scafato Emanuele , Gandin Claudia , Capurso Antonio , Solfrizzi Vincenzo 
Published: January 2008

AbstractBackgroundMild cognitive impairment (MCI) is often a prodromal of dementia and depressive symptoms have been suggested as risk factor for dementing disorders. We evaluated the possible impact of depressive symptoms on the rate of progression to dementia in MCI patients after a 3.5‐year follow‐up; and the interaction between depressive symptoms and vascular risk factors for conversion to dementia.MethodsA total of 2,963 individuals from a sample of 5,632 65–84 year old subjects were evaluated at the first (1992–1993), and second survey (1995–1996) of the Italian Longitudinal Study on Aging (ILSA), a prospective cohort study. MCI and dementia were classified using current clinical criteria. Depressive symptoms were measured with the Geriatric Depression Scale.ResultsAmong the 2,963 participants, 139 prevalent MCI patients were diagnosed at the first survey. During the 3.5‐year follow‐up, 14 MCI patients progressed to dementia, and we did not find any significant relationship between depressive symptoms and rate of progression to dementia (RR 1.42, 95% CI, 0.48–4.23, χ2 0.40, p < 0.53). No socio‐demographic variables or vascular risk factors modified the association between depressive symptoms and conversion to dementia.ConclusionsIn our population, depressive symptoms were not associated with the rate of progression to dementia in MCI patients. Our findings did not support a role of socio‐demographic variables or vascular risk factors in the association of depressive symptoms and conversion to dementia. Copyright © 2008 John Wiley & Sons, Ltd.
Fat intake at midlife and cognitive impairment later in life: a population‐based CAIDE study
Authors: Eskelinen Marjo H. , Ngandu Tiia , Helkala Eeva‐Liisa , Tuomilehto Jaakko , Nissinen Aulikki , Soininen Hilkka , Kivipelto Miia 
Published: January 2008

AbstractObjectiveTo investigate the association of midlife dietary fat intake to cognitive performance, and to the occurrence of clinical mild cognitive impairment (MCI) later in life in a non‐demented population.DesignA longitudinal population‐based study.SettingPopulations of Kuopio and Joensuu, Eastern Finland.Participants and methodsParticipants of the CAIDE study were derived from random, population‐based samples studied at midlife (1972, 1977, 1982 or 1987). After an average follow‐up of 21 years, a total of 1449 (72%) individuals aged 65–80 years participated in the re‐examination in 1998. Altogether 82 (5.7%) people were diagnosed as having MCI. Dietary information was collected with a structured questionnaire and an interview at midlife.Main outcome measuresMCI, global cognitive and executive functions, episodic, semantic and prospective memory and psychomotor speed.ResultsAbundant saturated fat (SFA) intake from milk products and spreads at midlife was associated with poorer global cognitive function and prospective memory and with an increased risk of MCI (OR 2.36, 95% CI 1.17–4.74) after adjusting for demographic and vascular factors, other fats and ApoE. On the contrary, high intake of polyunsaturated fatty acids (PUFA) was associated with better semantic memory. Also frequent fish consumption was associated with better global cognitive function and semantic memory. Further, higher PUFA–SFA ratio was associated with better psychomotor speed and executive function.ConclusionsOur data suggests that dietary fat intake at midlife affects cognitive performance and occurrence of MCI later in life. The impact of dietary interventions needs to be tested in clinical trials. Copyright © 2008 John Wiley & Sons, Ltd.
COX‐2 and p53 in human sinonasal cancer: COX‐2 expression is associated with adenocarcinoma histology and wood‐dust exposure
Authors: Holmila Reetta , Cyr Diane , Luce Danièle , Heikkilä Pirjo , Dictor Michael , Steiniche Torben , Stjernvall Tuula , Bornholdt Jette , Wallin Håkan , Wolff Henrik , Husgafvel‐Pursiainen Kirsti 
Published: January 2008

AbstractThe causal role of wood‐dust exposure in sinonasal cancer (SNC) has been established in epidemiological studies, but the mechanisms of SNC carcinogenesis are still largely unknown. Increased amounts of COX‐2 are found in both premalignant and malignant tissues, and experimental evidence link COX‐2 to development of cancer. Many signals that activate COX‐2 also induce tumor suppressor p53, a transcription factor central in cellular stress response. We investigated COX‐2 and p53 expressions by immunohistochemistry in 50 SNCs (23 adenocarcinomas, and 27 squamous cell carcinomas (SCC); 48 analyzed for COX‐2; 41 for p53). Occupational histories and smoking habits were available for majority of the cases. Most of the adenocarcinoma cases with exposure history data had been exposed to wood dust at work in the past (88%, 14/16). For smokers, 63% (12/19) presented with SSC, whereas 64% (7/11) of nonsmokers displayed adenocarcinoma. COX‐2 was expressed at higher levels in adenocarcinoma as compared to SSC (p < 0.001). COX‐2 expression showed significant association with occupational exposure to wood dust (p = 0.024), and with nonsmoking status (p = 0.001). No statistically significant associations between the exposures and p53 accumulation were found; however, the p53 accumulation pattern (p = 0.062 for wood dust exposure) resembled that of COX‐2 expression. In summary, our findings show increased COX‐2 expression in SNC adenocarcinoma with wood dust exposure, suggesting a role for inflammatory components in the carcinogenesis process. In contrast, SCCs predominated among smokers and expressed COX‐2 rarely; this may suggest at least partially different molecular mechanisms. © 2008 Wiley‐Liss, Inc.
Treating patients with two or more personality disorders: an introduction
Authors: Dimaggio Giancarlo , Norcross John C. 
Published: January 2008

AbstractA high percentage of patients diagnosed with one personality disorder (PD) have, at the same time, at least one other PD. However, psychotherapists lack clinical guidance and research evidence on treating such complex patients. This issue of the Journal of Clinical Psychology: In Session attempts to bridge the gap. In this Introduction, the editors outline the subsequent articles in this issue and address the terminology, prevalence, and possible causes of Axis II comorbidity. They argue that comorbidity is, in part, ascribable to problems in classification systems and can be reduced by defining PDs in a more multifaceted manner. They provide several clinical vignettes to portray frequent difficulties encountered by psychotherapists in treating these complex, co‐occurrent cases. © 2008 Wiley Periodicals, Inc. J Clin Psychol: In Session 64: 1–12, 2008.
Combination of anorganic bovine‐derived hydroxyapatite with binding peptide does not enhance bone healing in a critical‐size defect in a rabbit model
Authors: Sarahrudi Kambiz , Mousavi Mehdi , Grossschmidt Karl , Sela Nezir , König Franz , Vécsei Vilmos , Aharinejad Seyedhossein 
Published: January 2008

AbstractAnorganic bovine‐derived hydroxyapatite (ABM) in combination with binding peptid (P‐15) has demonstrated the capacity to improve the healing of periodontal defects. This study evaluated the benefit of ABM/P‐15 to promote healing of cortical long bone defects in a rabbit model. A 5‐mm segmental bone defect was created in the femur and fixed with a plate. There were two treatment groups: no implant (n = 12) and ABM/P‐15 (n = 12). At 4, 8, and 12 weeks, healing of the defect was evaluated with radiographs and histomorphometric examination of the treated femora. After 4 weeks, radiographs showed bone formation without signs of complete consolidation in three of four animals in the control group and two of four ABM/P‐15 treated animals. At the later course of the treatment, no radiologic difference was evident between the treatment groups. Histomorphometric evaluation revealed an area of 1.29 ± 0.11 mm2 and 0.97 ± 0.21 mm2 of newly produced bone in animals of the control group and ABM/P‐15 group after 4 weeks. After 8 and 12 weeks, animals in the control group had an area of 2.44 ± 0.62 mm2 and 2.5 ± 0.2 mm2 of newly produced bone within the osteotomy gap compared to 1.6 ± 0.65 mm2 and 1.56 ± 0.27 mm2 in the ABM/P‐15 group (p = 0.0004). An enhanced or accelerated ingrowth of bone, as reported in previous studies, was not observed. Our results imply that the ABM/P‐15 is not a suitable graft for the treatment of critical‐sized segmental defects in long bones. © 2008 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 26:759–763, 2008
Adhesions in a murine flexor tendon graft model: Autograft versus allograft reconstruction
Authors: Hasslund Sys , Jacobson Justin A. , Dadali Tulin , Basile Patrick , Ulrich‐Vinther Michael , Søballe Kjeld , Schwarz Edward M. , O'Keefe Regis J. , Mitten David J. , Awad Hani A. 
Published: January 2008

AbstractReconstruction of flexor tendons often results in adhesions that compromise joint flexion. Little is known about the factors involved in the formation of flexor tendon graft adhesions. In this study, we developed and characterized a novel mouse model of flexor digitorum longus (FDL) tendon reconstruction with live autografts or reconstituted freeze‐dried allografts. Grafted tendons were evaluated at multiple time points up to 84 days post‐reconstruction. To assess the flexion range of the metatarsophalangeal joint, we developed a quantitative outcome measure proportional to the resistance to tendon gliding due to adhesions, which we termed the Gliding Coefficient. At 14 days post‐grafting, the Gliding Coefficient was 29‐ and 26‐fold greater than normal FDL tendon for both autografts and allografts, respectively (p < 0.001), and subsequently doubled for 28‐day autografts. Interestingly, there were no significant differences in maximum tensile force or stiffness between live autograft and freeze‐dried allograft repairs over time. Histologically, autograft healing was characterized by extensive remodeling and exuberant scarring around both the ends and the body of the graft, whereas allograft scarring was abundant only near the graft–host junctions. Gene expression of GDF‐5 and VEGF were significantly increased in 28‐day autografts compared to allografts and to normal tendons. These results suggest that the biomechanical advantages for tendon reconstruction using live autografts over devitalized allografts are minimal. This mouse model can be useful in elucidating the molecular mechanisms in tendon repair and can aid in preliminary screening of molecular treatments of flexor tendon adhesions. © 2008 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 26:824–833, 2008
Measurement of bone blood flow using the hydrogen washout Technique—Part I: Quantitative evaluation of tissue perfusion in the laboratory rat
Authors: Pelzer Michael , Larsen Mikko , Friedrich Patricia F. , Bishop Allen T. 
Published: January 2008

AbstractThe measurement of blood flow in bone is of interest in both clinical and experimental settings. Such determinations would ideally provide accurate, quantitative, and reproducible data with relatively simple and safe technology, even in the small bones of experimental animals. Methods that provide absolute or quantitative measurements include positron emission tomography, “isotope fractioning” using radioactive or fluorescent‐labeled microspheres, and measurement of the rate of washout of diffusible tracers delivered either by injection or inhalation. In this article, we describe in detail a modification of the original Whiteside hydrogen washout technique, using modern hydrogen sensors, a micromanipulator for probe placement, and custom software that greatly simplifies blood flow determination and is effective in the small bones of experimental animals. © 2008 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 26:741–745, 2008
On some geometric and topological properties of generalized Orlicz–Lorentz sequence spaces
Authors: Foralewski Paweł , Hudzik Henryk , Szymaszkiewicz Lucjan 
Published: January 2008

AbstractGeneralized Orlicz–Lorentz sequence spaces λφ generated by Musielak‐Orlicz functions φ satisfying some growth and regularity conditions (see [28] and [33]) are investigated. A regularity condition δλ 2 for φ is defined in such a way that it guarantees many positive topological and geometric properties of λφ. The problems of the Fatou property, the order continuity and the Kadec–Klee property with respect to the uniform convergence of the space λφ are considered. Moreover, some embeddings between λφ and their two subspaces are established and strict monotonicity as well as lower and upper local uniform monotonicities are characterized. Finally, necessary and sufficient conditions for rotundity of λφ, their subspaces of order continuous elements and finite dimensional subspaces are presented. This paper generalizes the results from [19], [4] and [17]. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Lieb–Thirring inequalities for higher order differential operators
Authors: Förster Clemens , Östensson Jörgen 
Published: January 2008

AbstractWe derive Lieb–Thirring inequalities for the Riesz means of eigenvalues of order γ ≥ 3/4 for a fourth order operator in arbitrary dimensions. We also consider some extensions to polyharmonic operators, and to systems of such operators, in dimensions greater than one. For the critical case γ = 1 – 1/(2l) in dimension d = 1 with l ≥ 2 we prove the inequality L0l,γ,d < Ll,γ,d , which holds in contrast to current conjectures. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Drug‐induced and psychogenic resting suprahyoid neck and tongue tremors
Authors: Baik Jong Sam , Lyoo Chul H. , Lee Jae H. , Lee Myung Sik 
Published: January 2008

AbstractWe describe three patients who presented with 4 to 5 Hz tremors of the suprahyoid region of the neck. Two developed their tremors in association with levosulpiride treatment. When they opened their mouths, the neck tremors disappeared; no tongue tremors were observed. However, a videofluoroscopic examination showed the presence of tongue tremors at rest. The remaining patient had a psychogenic tremor. © 2008 Movement Disorder Society
American put option with regime‐switching volatility (finite time horizon)—Variational inequality approach
Authors: Yi Fahuai 
Published: January 2008

AbstractWe study the fair price of American put option with regime‐switching volatility. Assuming that volatility σ(t) takes two different values σ1 and σ2, applying Δ hedging technique we obtain a system of evolutionary variational inequalities, which possesses two free boundaries (optimal exercise boundaries). The following are the main results of this paper.

Two free boundaries are monotonic and infinitely differentiable.
The optimal exercise boundary of American put option with regime‐switching volatility in the bearish (or bullish) market is smaller (or higher) than the one of standard American put option.And the price of American put option with regime‐switching volatility in the bearish (or bullish) market is higher (or smaller) than the one of standard American put option.
The solution of problem (1) is unique.
These results are original in the option pricing with regime‐switching volatility, the proof is technical. Copyright © 2008 John Wiley & Sons, Ltd.
Methodological approaches in the assessment of interferon‐alfa‐induced depression in patients with chronic hepatitis C – a critical review
Authors: Schäfer Arne , Wittchen Hans‐Ulrich , Seufert Jochen , Kraus Michael R. 
Published: January 2008

AbstractIn recent years, research on interferon (IFN)‐induced depressive symptoms in antivirally treated patients suffering from chronic hepatitis C (CHC) has considerably intensified. Profound scientific knowledge of this complication is of great relevance with regard to adherence, compliance, and premature therapy discontinuation.Presently, there is considerable variability of both, the frequency and extent of IFN‐induced depression reported in different cohorts of patients.The aim of the presented study was to systematically review recent literature of research within this field; and particularly (1) to identify to what extent methodological bias contributed to inconsistent results in different studies, (2) to critically appraise methods and results of studies published so far, and (3) to suggest directions for future work, especially with respect to alternative and improved methodological approaches.The results of this critical review suggest that the variability of findings seem to be largely due to different study populations, treatment regimens, methodological approaches, and sometimes arbitrary or at least poorly defined choice of screening instruments for depression, particularly criteria for clinically relevant depression (cut‐off criteria).Study designs and methodological approaches to investigate IFN‐alfa‐induced depression in patients with CHC have been incoherent. Future research in this field needs agreement on the use of standardized assessment of IFN‐induced depression in CHC. Furthermore, objective criteria and guidelines for the treatment of IFN‐induced depression in these patients are needed in clinical practice. Copyright © 2008 John Wiley & Sons, Ltd.