bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inequality on the frontline: A multi-country study on gender differences in mental health among healthcare workers during the COVID-19 pandemic
Authors: Czepiel Diana , McCormack Clare , da Silva Andréa T.C. , Seblova Dominika , Moro Maria F. , Restrepo-Henao Alexandra , Martínez Adriana M. , Afolabi Oyeyemi , Alnasser Lubna , Alvarado Rubén , Asaoka Hiroki , Ayinde Olatunde , Balalian Arin , Ballester Dinarte , Barathie Josleen A.l. , Basagoitia Armando , Basic Djordje , Burrone María S. , Carta Mauro G. , Durand-Arias Sol , Eskin Mehmet , Fernández-Jiménez Eduardo , Frey Marcela I. F. , Gureje Oye , Isahakyan Anna , Jaldo Rodrigo , Karam Elie G. , Khattech Dorra , Lindert Jutta , Martínez-Alés Gonzalo , Mascayano Franco , Mediavilla Roberto , Narvaez Gonzalez Javier A. , Nasser-Karam Aimee , Nishi Daisuke , Olaopa Olusegun , Ouali Uta , Puac-Polanco Victor , Ramírez Dorian E. , Ramírez Jorge , Rivera-Segarra Eliut , Rutten Bart P.F. , Santaella-Tenorio Julian , Sapag Jaime C. , Šeblová Jana , Soto María T. S. , Tavares-Cavalcanti Maria , Valeri Linda , Sijbrandij Marit , Susser Ezra S. , Hoek Hans W. , van der Ven Els 
Published: March 2024

Abstract
Healthcare workers (HCWs) were at increased risk for mental health problems during the COVID-19 pandemic, with prior data suggesting women may be particularly vulnerable. Our global mental health study aimed to examine factors associated with gender differences in psychological distress and depressive symptoms among HCWs during COVID-19. Across 22 countries in South America, Europe, Asia and Africa, 32,410 HCWs participated in the COVID-19 HEalth caRe wOrkErS (HEROES) study between March 2020 and February 2021. They completed the General Health Questionnaire-12, the Patient Health Questionnaire-9 and questions about pandemic-relevant exposures. Consistently across countries, women reported elevated mental health problems compared to men. Women also reported increased COVID-19-relevant stressors, including insufficient personal protective equipment and less support from colleagues, while men reported increased contact with COVID-19 patients. At the country level, HCWs in countries with higher gender inequality reported less mental health problems. Higher COVID-19 mortality rates were associated with increased psychological distress merely among women. Our findings suggest that among HCWs, women may have been disproportionately exposed to COVID-19-relevant stressors at the individual and country level. This highlights the importance of considering gender in emergency response efforts to safeguard women’s well-being and ensure healthcare system preparedness during future public health crises.
Old Epistemic Vices and Islamophobia in Martha Nussbaum's The New Religious Intolerance
Authors: Alsayyed Tasneem 
Published: March 2024

AbstractMartha Nussbaum in her The New Religious Intolerance (2012) commits several old forms of epistemic vice including exclusion, orientalism, and colonial discourse. Unsurprisingly, as a result, her text contributes to the production of ignorance about Muslims and Muslim women despite her intention of combating Islamophobia. In this article, I specifically critique Nussbaum's anti-burqa-ban arguments and her pro-airport-profiling stance. To do so, I draw on the work of Audre Lorde and other feminist scholars and scholars of color to express the harms of excluding Muslim voices and misusing Western/white voices in their place. Recalling Edward Said, Marilyn Frye, and María Lugones, I argue that Nussbaum's text is a classic example of orientalism and various forms of colonial discourse.
The NIH-Moderna Vaccine: Public Science, Private Profit, and Lessons for the Future
Authors: Morten Christopher J. 
Published: March 2024

AbstractThis commentary highlights the scientific history of the NIH-Moderna COVID-19 vaccine and corroborates Sarpatwari’s theme of private capture of value created by the public. The commentary also identifies missteps by the Trump and Biden Administrations and offers policy recommendations: better contracts with and incentives for pharmaceutical manufacturers and a not-for-profit “public option” for pharmaceutical development.
Computer-aided design tool for typical flexible mechanisms synthesis by means of evolutionary algorithms
Authors: Ben Abdallah Mohamed Amine , Khemili Imed , Aifaoui Nizar , Laribi Med Amine 
Published: March 2024

AbstractAccurate prediction for mechanisms’ dynamic responses has always been a challenging task for designers. For modeling easiness purposes, mechanisms’ synthesis and optimization have been mostly limited to rigid systems, making consequently the designer unable to vow that the manufactured mechanism satisfies the target responses. To address this limitation, flexible mechanism synthesis is aimed in this work. Two benchmark mechanisms being the core of myriad mechanical devices are of scope, mainly, the flexible slider-crank and the four-bar. In addition to the mechanism dimensions, materials properties have been embedded in the synthesis problem. Two responses are of interest for the slider-crank mechanism, the slider velocity, and the midpoint axial displacement for the flexible connecting rod. Whereas five responses have been compiled for the four-bar mechanism synthesis. A comparative analysis of seven optimization techniques to solve the synthesis problem for both mechanisms has been performed. Subsequently, an executable computer-aided design tool for mechanisms synthesis has been developed under MATLAB®. Numerical outcomes emphasize the limits of a single-response-based synthesis for a flexible mechanism. It has been proven that combining different responses alleviates possible error and fulfill high-accuracy requirement.
The Sultans of Zanzibar and the Abolition of Slavery in East Africa
Authors: Liebst Michelle 
Published: March 2024

AbstractIn 1890, Sultan Ali of Zanzibar declared in writing that “we wish by every means to stop the slave trade.” Statements like these, in addition to the actual passing of anti-slavery legislation, call into question the generally accepted scholarly understanding that the sultans of Zanzibar only agreed to pass and enforce anti-slavery legislation because they were under duress from European, mainly British, powers, who negotiated favorable political and economic benefits in return for (gradual) abolition. A close analysis of the sources tells a more complicated story of both collaboration and conflict between the Zanzibari sultans, their subjects, and the British agents. Moreover, each sultan had distinctive political and religious beliefs, as well as individual personal experiences and outlooks. This paper explores the anti-slavery legislation passed under three sultans of Zanzibar: Barghash bin Said (1870–1888) who prohibited the transport of slaves by sea in 1873, Ali bin Said (1890–1893) who passed the Slave Trade Prohibition Decree of 1890, and Hamoud bin Mohammed (1896–1902) who passed the Abolition Decree of 1897. By analyzing draft treaties and correspondence before and after the passing of legislation, this paper argues that the sultans and their advisors were not devoid of ideological interest in ending slavery; and that British agents and explorers in the region were too hastily hailed as abolitionists.
Reducing the carbon footprint of diets across socio-demographic groups in Finland: a mathematical optimisation study
Authors: Irz Xavier , Tapanainen Heli , Saarinen Merja , Salminen Jani , Sares-Jäske Laura , Valsta Liisa M 
Published: March 2024

Abstract

Objectives:
To characterise nutritionally adequate, climate-friendly diets that are culturally acceptable across socio-demographic groups. To identify potential equity issues linked to more climate-friendly and nutritionally adequate dietary changes.

Design:
An optimisation model minimises distance from observed diets subject to nutritional, greenhouse gas emissions (GHGE) and food-habit constraints. It is calibrated to socio-demographic groups differentiated by sex, education and income levels using dietary intake data. The environmental coefficients are derived from life cycle analysis and an environmentally extended input–output model.

Setting:
Finland.

Participants:
Adult population.

Results:
Across all population groups, we find large synergies between improvements in nutritional adequacy and reductions in GHGE, set at one-third or half of the current level. Those reductions result mainly from the substitution of meat with cereals, potatoes and roots and the intra-category substitution of foods, such as beef with poultry in the meat category. The simulated more climate-friendly diets are thus flexitarian. Moving towards reduced-impact diets would not create major inadequacies related to protein and fatty acid intakes, but Fe could be an issue for pre-menopausal females. The initial socio-economic gradient in the GHGE of diets is small, and the patterns of adjustments to more climate-friendly diets are similar across socio-demographic groups.

Conclusions:
A one-third reduction in GHGE of diets is achievable through moderate behavioural adjustments, but achieving larger reductions may be difficult. The required changes are similar across socio-demographic groups and do not raise equity issues. A population-wide policy to promote behavioural change for diet sustainability would be appropriate.
Adherence to the national guidance on foods and drinks to limit or avoid during pregnancy in England: the PEAR Study
Authors: Beasant Lucy , Ingram Jenny , Emmett Pauline M , Cade Janet E , Taylor Caroline M 
Published: March 2024

Abstract

Objective:
The National Health Service (NHS) England website provides guidance on foods/drinks to avoid or limit during pregnancy because of microbiological, toxicological or teratogenic hazards. The aims were to determine adherence and whether demographic characteristics were associated with adherence.

Design:
Cross-sectional study.

Setting:
Online survey of postpartum women resident in England during pregnancy.

Participants:
Recently, postpartum women resident in England during their pregnancy (n 598; median age 33 (IQR 30–36) years) completed an online questionnaire (April–November 2022). Questions included those on consumption of twenty-one food/drink items that the NHS advises pregnant women to avoid/limit. The study is part of the Pregnancy, the Environment And nutRition (PEAR) Study. Summary statistics were used to determine proportions adhering to the guidance. Adjusted logistic regression was used to model the associations of adherence with demographic characteristics.

Results:
Adherence was generally high (>90 % for eight of ten food/drink items to be avoided). However, among pre-pregnancy consumers, several items were not completely avoided, for example, 81 % (128/158) for game meat/gamebirds, 37 % (176/478) for cured meats and 17 % (81/467) for soft cheeses. Greater educational attainment (e.g. caffeinated soft drinks OR 2·25 (95 % CI 1·28, 3·94)), greater maternal age (e.g. oily fish 1·64 (1·05, 2·56)) and lower parity (e.g. caffeinated coffee 0.28 (0.11, 0.69)) were the most usual characteristics associated with adherence.

Conclusion:
Evidence of concerning levels of non-adherence for some food/drink items suggests a case for more education on some of the guidance, particularly for women with lower educational attainment, greater parity and greater maternal age. Further research on barriers to the implementation of the guidance is needed.
ENERGY BOUNDS FOR MODULAR ROOTS AND THEIR APPLICATIONS
Authors: Kerr Bryce , Shkredov Ilya D. , Shparlinski Igor E. , Zaharescu Alexandru 
Published: March 2024

Abstract
We generalise and improve some recent bounds for additive energies of modular roots. Our arguments use a variety of techniques, including those from additive combinatorics, algebraic number theory and the geometry of numbers. We give applications of these results to new bounds on correlations between Salié sums and to a new equidistribution estimate for the set of modular roots of primes.
Rare inheritance studies on yellow sarson for petalous and apetalous traits
Authors: Bisht Charu , Prasad Birendra , Pant Usha , Verma Sanjay Kumar , Gaur Amit Kumar , Gupta Shubham , Panwar Neha , Joshi Sivendra , Bisht Yashpal Singh , Prashad Himanshu , Deep Harsh 
Published: March 2024

AbstractThis study investigates the inheritance pattern of petalous and apetalous traits in yellow sarson (Brassica rapa var yellow sarson) and its significance for breeding efforts. Utilizing three crucial crosses between petalous (Pant Sweta, Pant Girija, YSH0401) and ‘apetalous’ parents, we observed the absence of apetalous plants in the F1 generation, indicating dominant inheritance of petalous plants. The F2 generation consistently displayed a 3:1 ratio of petalous to apetalous plants, confirming the dominance of the petalous trait. Chi-squared tests on each generation supported this conclusion. Backcrosses with petalous parents yielded no fruit, reinforcing the dominance of the petalous trait. Chi-squared tests on these backcrosses further confirmed the dominance inheritance pattern. Conversely, backcrosses with apetalous parents consistently exhibited a 1:1 ratio, highlighting the recessive nature of the apetalous trait. The study underscores the importance of understanding the inheritance pattern of petalous and apetalous traits in B. rapa var yellow sarson crop, as it has implications for breeding goals. Knowledge on trait inheritance can guide future breeding strategies, facilitating the transfer of the apetalous trait as needed. This study provides valuable insights for genetic investigations and breeding initiatives in B. rapa var yellow sarson.
Strong Lensing by Galaxies: Past Highlights, Current Status, and Future Prospects
Authors: Shajib Anowar J. 
Published: March 2024

AbstractGalaxy-scale strong lensing is a powerful tool in Astrophysics and Cosmology, enabling studies of massive galaxies’ internal structure, their formation and evolution, stellar initial mass function, and cosmological parameters. In this conference proceeding, we highlight key findings from the past decade in astrophysical applications of strong lensing at the galaxy scale. We then briefly summarize the present status of discovery and analyses of new samples from recent or ongoing surveys. Finally, we offer insights into anticipated developments in the upcoming era of big data shaping the future of this field, thanks to the Rubin, Euclid, and Roman observatories.
A Comprehensive Assessment of Submarine Landslides and Mass Wasting Processes Offshore Southern California
Authors: Walton Maureen A. L. , Conrad James E. , Papesh Antoinette G. , Brothers Daniel S. , Kluesner Jared W. , McGann Mary , Dartnell Peter 
Published: March 2024

AbstractIt is critical to characterize submarine landslide hazards near dense coastal populations, especially in areas with active faults, which can trigger slope failure, subsequent tsunamis, and damage seabed infrastructure during earthquake shaking. Offshore southern California, numerous marine geophysical surveys have been conducted over the past decade, and high‐resolution bathymetric and subsurface data now cover about 60 percent of the total region between Point Conception and the United States‐Mexico border from the California coast out to the base of Patton Escarpment ∼200 km offshore. In a comprehensive compilation and interpretive mapping effort, we find evidence of seafloor failure throughout offshore southern California with nearly 1,500 submarine landslide‐related features, including 63 discrete slide deposits with debris and >1,400 slide‐related scarps. In our analysis, we highlight new mapping of submarine landslides in Catalina Basin, the Del Mar slide, the San Gabriel slide complex, and the 232 km2 San Nicolas slide, the largest area of any known submarine landslide mass offshore southern California. Analysis of the spatial distribution of submarine landslide features suggests that most mapped slide features are located relatively near coastal sediment sources, particularly during sea‐level lowstand conditions, which underscores the importance of sediment supply and sediment accumulation on low‐gradient slopes as failure preconditioning processes. Tectonically driven uplift at shelf edges and along basin flanks is another key preconditioning factor, and our results also suggest that earthquakes along active faults trigger mass wasting, especially for repeated, small‐scale failures on tectonically steepened slopes.
Summer Deep Depressions Increase Over the Eastern North Atlantic
Authors: D'Andrea Fabio , Duvel Jean‐Philippe , Rivière Gwendal , Vautard Robert , Cassou Christophe , Cattiaux Julien , Coumou Dim , Faranda Davide , Happé Tamara , Jézéquel Aglaé , Ribes Aurelien , Yiou Pascal 
Published: March 2024

AbstractMid‐tropospheric deep depressions in summer over the North Atlantic are shown to have strongly increased in the eastern and strongly decreased in the western North Atlantic region. This evolution is linked to a change in baroclinicity in the west of the North Atlantic ocean and over the North American coast, likely due to the increased surface temperature there. Deep depressions in the Eastern North Atlantic are linked to a temperature pattern typical of extreme heat events in the region. The same analysis is applied to a sample of CMIP6 model outputs, and no such trends are found. This study suggests a link between the observed increase of summer extreme heat events in the region and the increase of the number of Atlantic depressions. The failure of CMIP6 models to reproduce these events can consequently also reside in an incorrect reproduction of this specific feature of midlatitude atmospheric dynamics.
NF-κB in biology and targeted therapy: new insights and translational implications
Authors: Guo Qing , Jin Yizi , Chen Xinyu , Ye Xiaomin , Shen Xin , Lin Mingxi , Zeng Cheng , Zhou Teng , Zhang Jian 
Published: March 2024

AbstractNF-κB signaling has been discovered for nearly 40 years. Initially, NF-κB signaling was identified as a pivotal pathway in mediating inflammatory responses. However, with extensive and in-depth investigations, researchers have discovered that its role can be expanded to a variety of signaling mechanisms, biological processes, human diseases, and treatment options. In this review, we first scrutinize the research process of NF-κB signaling, and summarize the composition, activation, and regulatory mechanism of NF-κB signaling. We investigate the interaction of NF-κB signaling with other important pathways, including PI3K/AKT, MAPK, JAK-STAT, TGF-β, Wnt, Notch, Hedgehog, and TLR signaling. The physiological and pathological states of NF-κB signaling, as well as its intricate involvement in inflammation, immune regulation, and tumor microenvironment, are also explicated. Additionally, we illustrate how NF-κB signaling is involved in a variety of human diseases, including cancers, inflammatory and autoimmune diseases, cardiovascular diseases, metabolic diseases, neurological diseases, and COVID-19. Further, we discuss the therapeutic approaches targeting NF-κB signaling, including IKK inhibitors, monoclonal antibodies, proteasome inhibitors, nuclear translocation inhibitors, DNA binding inhibitors, TKIs, non-coding RNAs, immunotherapy, and CAR-T. Finally, we provide an outlook for research in the field of NF-κB signaling. We hope to present a stereoscopic, comprehensive NF-κB signaling that will inform future research and clinical practice.
New clinical trial design in precision medicine: discovery, development and direction
Authors: Duan Xiao-Peng , Qin Bao-Dong , Jiao Xiao-Dong , Liu Ke , Wang Zhan , Zang Yuan-Sheng 
Published: March 2024

AbstractIn the era of precision medicine, it has been increasingly recognized that individuals with a certain disease are complex and different from each other. Due to the underestimation of the significant heterogeneity across participants in traditional “one-size-fits-all” trials, patient-centered trials that could provide optimal therapy customization to individuals with specific biomarkers were developed including the basket, umbrella, and platform trial designs under the master protocol framework. In recent years, the successive FDA approval of indications based on biomarker-guided master protocol designs has demonstrated that these new clinical trials are ushering in tremendous opportunities. Despite the rapid increase in the number of basket, umbrella, and platform trials, the current clinical and research understanding of these new trial designs, as compared with traditional trial designs, remains limited. The majority of the research focuses on methodologies, and there is a lack of in-depth insight concerning the underlying biological logic of these new clinical trial designs. Therefore, we provide this comprehensive review of the discovery and development of basket, umbrella, and platform trials and their underlying logic from the perspective of precision medicine. Meanwhile, we discuss future directions on the potential development of these new clinical design in view of the “Precision Pro”, “Dynamic Precision”, and “Intelligent Precision”. This review would assist trial-related researchers to enhance the innovation and feasibility of clinical trial designs by expounding the underlying logic, which be essential to accelerate the progression of precision medicine.
Suppression of ITPKB degradation by Trim25 confers TMZ resistance in glioblastoma through ROS homeostasis
Authors: Yan Yuanliang , Zhou Shangjun , Chen Xi , Yi Qiaoli , Feng Songshan , Zhao Zijin , Liu Yuanhong , Liang Qiuju , Xu Zhijie , Li Zhi , Sun Lunquan 
Published: March 2024

AbstractTemozolomide (TMZ) represents a standard-of-care chemotherapeutic agent in glioblastoma (GBM). However, the development of drug resistance constitutes a significant hurdle in the treatment of malignant glioma. Although specific innovative approaches, such as immunotherapy, have shown favorable clinical outcomes, the inherent invasiveness of most gliomas continues to make them challenging to treat. Consequently, there is an urgent need to identify effective therapeutic targets for gliomas to overcome chemoresistance and facilitate drug development. This investigation used mass spectrometry to examine the proteomic profiles of six pairs of GBM patients who underwent standard-of-care treatment and surgery for both primary and recurrent tumors. A total of 648 proteins exhibiting significant differential expression were identified. Gene Set Enrichment Analysis (GSEA) unveiled notable alterations in pathways related to METABOLISM_OF_LIPIDS and BIOLOGICAL_OXIDATIONS between the primary and recurrent groups. Validation through glioma tissue arrays and the Xiangya cohort confirmed substantial upregulation of inositol 1,4,5-triphosphate (IP3) kinase B (ITPKB) in the recurrence group, correlating with poor survival in glioma patients. In TMZ-resistant cells, the depletion of ITPKB led to an increase in reactive oxygen species (ROS) related to NADPH oxidase (NOX) activity and restored cell sensitivity to TMZ. Mechanistically, the decreased phosphorylation of the E3 ligase Trim25 at the S100 position in recurrent GBM samples accounted for the weakened ITPKB ubiquitination. This, in turn, elevated ITPKB stability and impaired ROS production. Furthermore, ITPKB depletion or the ITPKB inhibitor GNF362 effectively overcome TMZ chemoresistance in a glioma xenograft mouse model. These findings reveal a novel mechanism underlying TMZ resistance and propose ITPKB as a promising therapeutic target for TMZ-resistant GBM.