bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parasitaemia and fever in uncomplicated Plasmodium vivax malaria: a systematic review and individual patient data meta-analysis
Authors: Groves Emily S , Simpson Julie A , Edler Peta , Daher André , Pasaribu Ayodhia P , Pereira Dhelio B , Saravu Kavitha , von Seidlein Lorenz , Rajasekhar Megha , Price Ric N , Commons Robert J 
Published: March 2024

Abstract
Background
Parasite density thresholds for diagnosing symptomatic malaria are defined by the relationship between parasitaemia and fever; they inform the development of novel diagnostic tests. Thresholds for diagnosing Plasmodium vivax malaria remain poorly defined.
Methods
We undertook an individual patient data meta-analysis of P. vivax clinical trials mapped to the WorldWide Anti-Malarial Resistance Network (WWARN) repository and used parasitaemia centiles of febrile patients at enrolment to derive the proportion of patients who would have been diagnosed at different symptomatic parasite densities. Febrile and afebrile patients with recurrent infections during follow-up were selected to determine pyrogenic densities using receiver operating characteristic curve analysis.
Results
In total 13,263 patients from 50 studies were included in the analysis. In 27 studies that did not apply a parasitaemia threshold as an inclusion criterion, the median parasitaemia of 8,378 febrile patients at enrolment was 3,280/µL (interquartile range, 968–8,320). 90% of patients had a parasitaemia above 278/µL (10th centile), and 95% above 120/µL (5th centile). The 10th parasitaemia centile was higher in children < 5 years old (368/µL) compared to adults ≥15 years (240/µL). In regions of high relapse periodicity (Southeast Asia and Oceania) febrile patients presented with lower parasitaemias (10th centile 185/µL vs. 504/µL) and a wider range of parasitaemias compared to those from low relapse periodicity regions (interquartile range 760/µL – 8,774/µL vs. 1,204/µL – 8,000/µL).
Trial registration
This trial was registered with PROSPERO: CRD42021254905. The date of the first registration was 17th May 2021.
Artificial Intelligence Use in Collaborative Network Processes
Authors: Andres Beatriz , Fernandez-Garcia David , Urze Pala , Araujo Emilia 
Published: March 2024

Abstract
The paper seeks to outline the impact of artificial intelligence (AI) on collaborative networks (CNs) by thoroughly examining the current literature. Given the growth of AI and its limited exploration in many business strategies, especially when collaboration among networked partners is established, this paper focuses on defining the research lines and AI application in CN processes by advancing some relevant ideas about how AI can improve networks’ resilience and antifragility. It discusses research on the integration of AI in CN from the following perspectives: (i) the collaborative processes addressed, (ii) the level of decision-making, (iii) the partners involved in the collaboration; (iv) the technologies that are jointly used with AI to support CN processes; (v) the programming languages implemented to develop AI algorithms; (vi) the sectors in which it AI is mainly implemented, and (vi) the potentialities of IA in CN in an increasingly turbulent and disruptive business world. The literature review has provided a global comprehension of the interplay between CN processes and AI-driven advancements, providing a response about the technologies that can merge with AI to support CN processes. The results derived from the literature analysis have allowed the establishment of a conceptual framework for AI use in CNs and outline future research directions in this field of study.
LVM manifolds and lck metrics
Authors: Faucard Bastien 
Published: March 2024

Abstract

In this paper, we compare two type of complex non-Kähler manifolds : LVM and lck manifolds. First, lck manifolds (for locally conformally Kähler manifolds) admit a metric which is locally conforme to a Kähler metric. On the other side, LVM manifolds (for S.Lopez de Medrano, A.Verjovsky and L.Meersseman) are quotient of an open subset of C^n by an action of C*xC^m. LVM and lck manifolds have a fondamental common point : Hopf manifolds which are a specific case of LVM manifolds and which admit also lck metric. So the question of this paper is :
Are LVM manifolds lck ?
We provide some answers to this question. The results obtained are as follows. In the set of all LVM manifolds, there is a dense subset of LVM which are not lck. An if we consider lck manifolds with potential (whose metric derives from a potential), the diagonal Hopf manifolds are the only LVM manifolds which admit an lck metric with potential. Based on this observation, we show that there exists an lck covering with potential (non-compact) of a certain subclass of LVM manifolds. Finally, we present some examples.
Mathematics Subject Classification (2000).
Primary 32J27, 32L05, 32M99, 32Q15, 32Q60, 32T15, 32V99;
Secondary 53A30, 53B35, 53C55, 53C56.
Ribavirin’s Daily Dose Growth Determined as the Result of Medicament Testing May Be a Predictor of the Chronic Course of the Disease in Long COVID Syndrome Patients
Authors: Djumaeva Naylya , Djumaeva Leyla , Akhunjanova Gulnara , Urunova Dilbar 
Published: March 2024

Abstract
Introduction
Long COVID syndrome, a multisystemic condition resulting from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, affects at least 65 million people worldwide. The disease pathogenesis is unclear, and many different assumptions still exist. This study aimed to explore the use of medicament testing to determine the optimal daily dose of ribavirin through the use of electroacupuncture via the Voll (EAV) diagnostic system for acupuncture points.
Materials and methods
One hundred one patients (aged 16 to 50) with long COVID syndrome were recruited from the Research Institute of Virology and were eligible according to the inclusion criteria. Patients were randomized to the experimental or the placebo groups. The patients were further examined with EAV diagnostics based on the level of electrodermal activity at the acupuncture points, followed by medicament testing with ribavirin (tablets) to determine the daily doses of the drug. Fifty-two participants were randomized to the experimental group and fourty nine to the placebo group and were considered for data analyses.
Results
The results of this study demonstrated the feasibility of using EAV to identify meridians with decreased levels of electrodermal activity at acupuncture points, followed by medicament testing with ribavirin to restore the decreased electrodermal conductivity at the studied acupuncture points and to measure the daily dose of the drug.
Conclusions
The measured daily doses of ribavirin in patients with long COVID syndrome may indirectly serve as a prognostic marker of the course of the disease. However, further clinical and instrumental studies are needed to evaluate the clinical application of medicament testing in assessing long-term COVID syndrome.
Self-care practices and associated factors among hypertensive patients attending at public hospital in Hawassa city, Sidama region, Ethiopia, 2023: Facility-based cross-sectional study
Authors: Asefa Abriham , Dukamo Nigussie , Misganaw Samuel , Legese Deresse , Jikamo Birhanu 
Published: March 2024

Abstract
Background
Self-care is crucial for controlling blood pressure in hypertensive patients. Globally, uncontrolled blood pressure resulted in 17.3 million fatalities and 9.4 million complications. Thereby, the purpose of this study was to assess the level of self-care behaviors and associated factors among hypertension patients in the public hospitals of Hawassa City.
Methods and materials:
From March 18, 2023 to June 18, 2023, a facility-based cross-sectional study was carried out at public hospitals in Hawassa. A systematic random sampling technique was used to select the study participants from each hospital. The six domains of Hypertension Self-Care Activity Level Effects (H-SCALE) measure how well people manage their hypertension. To evaluate the correlation between the dependent and independent variables, a binary logistic regression model was used. The results of the final model are presented as adjusted odds ratios (AORs) with 95% confidence intervals. These variables were regarded as independent predictors of poor self-care among patients with hypertension when their 95% confidence intervals did not include one in the final model. Adjusted odds ratios (AORs) with 95% confidence intervals are reported.
Result
Male participants were 56% less likely to practice poor self-care practices for hypertension compared to female participants. Those participant’s age group between 60–99 had 4.11 times higher odds of poor self-care practice compared to the participants of age group of 18–39, less than five years since being diagnosed with hypertension were 3.14 times more likely to practice poor self-care compared > five years, Patients who have comorbidity, Patients who chewed khat, and those who were not employed had 1.90 times higher odds of poor self-care practice than employed participants
Conclusion and recommendation:
Poor self-care was reported by 46.9% of respondents who were hypertension patients. We identified significant factors, such as sex, age, occupation, chewing khat, age 5 years from diagnosis, and comorbidities, associated with poor self-care practices among hypertension patients. The identified causes of the participants' poor self-care practices in the study settings should be addressed by policymakers, the regional bureau, healthcare professionals, and researchers, according to our recommendation.
Chemical and Resistive Switching Properties of Elaeodendron Buchananii Extract-Carboxymethyl Cellulose Composite: A Potential Active Layer for Biodegradable Memory Devices
Authors: Dlamini Z.W. , Vallabhapurapu S. , Nambooze J. , Erasmus E. , Mogale R. , Wilhelm A. , Swart  , Vallabhapurapu VS. , Mamba B. , Seltalentoa W. , Mahule TS. , Pellegrini VOL. , Polikarpov I. 
Published: March 2024

Abstract

Biodegradable electronic devices play a crucial role in addressing the escalating issue of electronic waste accumulation, which poses significant environmental threats. In this investigation, we explored the utilization of a methanol-based extract of the Elaeodendron buchananii plant blended with carboxymethyl cellulose, a biopolymer, to produce a biodegradable and environmentally friendly functional material for a resistive switching memory system using silver and tungsten electrodes. Our analyses revealed that these two materials chemically interacted to generate a perfect composite with near semiconducting optical bandgap (4.01 eV ), surpassing than that of individual materials. The resultant device exhibited O-type memory behavior, with a low ON/OFF ratio, strong endurance (≥ 103 write/erase cycles), and satisfactory (≥ 103) data retention. Furthermore through a comprehensive transport mechanism analysis , we observed the formation of traps in the composite significantly improved conduction in the device. In addition, we established that altering the voltage amplitude modifies the concentration of traps, leading in voltage amplitude driven multiple resistance states. Overall, our findings underscore the potential of functionalizing polymers can be functionalized by incorporating plant extracts, thereby resulting in biodegradable nonvolatile memory devices with promising performance metrics
Long-term dynamics of remote sensing indicators to monitor the dynamism of ecosystems in arid and semi-arid areas: contributions to sustainable resource management
Authors: Keria Hadjer , Bensaci Ettayib , Zoubiri Asma , Ben Si Said Zineb 
Published: March 2024

ABSTRACT

Climate change's impact on wetlands has heightened concerns regarding the growing incidence of drought. It is imperative to continuously monitor long-term changes in wetlands to detect variations. This study evaluates the enduring variability of remote sensing indicators within 25 watershed areas in Algeria, recognized for their substantial biodiversity. We employed two robust statistical techniques (linear regression and the Mann-Kendall test) with data from diverse sources, including MODIS satellite data. From a time-series dataset spanning 22 years, we assembled several pivotal indicators: normalized difference vegetation index (NDVI), enhanced vegetation index (EVI), normalized difference water index (NDWI), and land surface temperature (LST), selected to evaluate vegetation and water stress within the study areas. Our analysis revealed that NDVI showed more conspicuous temporal response when compared with EVI and NDWI. We uncovered negative correlations between NDVI and LST, underscoring the influence of drought and plant stress on vegetation within the study areas (R² = 0.109 to R² = 0.5701). Our Mann-Kendall trend analysis underscored the significance of NDVI and its robust association with EVI and NDWI. Understanding the dynamics of vegetation and water stress is of paramount importance for projecting changes in ecosystems, particularly within water bodies subject to climate variability.
Identification and Verification of Metabolism-related Immunotherapy Features and Prognosis in Lung Adenocarcinoma
Authors: Luo Junfang , An Jinlu , Jia Rongyan , Liu Cong , Zhang Yang 
Published: March 2024

Background:
Lung cancer is a frequent malignancy with a poor prognosis.
Extensive metabolic alterations are involved in carcinogenesis and could, therefore,
serve as a reliable prognostic phenotype.

Aims:
Our study aimed to develop a prognosis signature and explore the relationship between
metabolic characteristic-related signature and immune infiltration in lung adenocarcinoma
(LUAD).

Objective:
TCGA-LUAD and GSE31210 datasets were used as a training set and a validation
set, respectively.

Methods:
A total of 513 LUAD samples collected from The Cancer Genome Atlas
database (TCGA-LUAD) were used as a training dataset. Molecular subtypes were classified
by consensus clustering, and prognostic genes related to metabolism were analyzed
based on Differentially Expressed Genes (DEGs), Protein-Protein Interaction (PPI)
network, the univariate/multivariate- and Lasso- Cox regression analysis.

Results:
Two molecular subtypes with significant survival differences were divided by
the metabolism gene sets. The DEGs between the two subtypes were identified by integrated
analysis and then used to develop an 8-gene signature (TTK, TOP2A, KIF15, DLGAP5,
PLK1, PTTG1, ECT2, and ANLN) for predicting LUAD prognosis. Overexpression
of the 8 genes was significantly correlated with worse prognostic outcomes. RiskScore
was an independent factor that could divide LUAD patients into low- and high-risk
groups. Specifically, high-risk patients had poorer prognoses and higher immune escape.
The Receiver Operating Characteristic (ROC) curve showed strong performance of the
RiskScore model in estimating 1-, 3- and 5-year survival in both training and validation
sets. Finally, an optimized nomogram model was developed and contributed the most to
the prognostic prediction in LUAD.

Conclusion:
The current model could help effectively identify high-risk patients and
suggest the most effective drug and treatment candidates for patients with LUAD.
The Main Directions of Socialization Pupils of Children's Institutions Voronezh Region in the 1930s
Authors: Filonenko T. V. , Menzhulin V. A. 
Published: March 2024

Relevance. The readers are offered a plot dedicated to various aspects and directions of the socialization of orphanages in the 1930s. Socialization meant instilling work skills in pupils, training in the scope of secondary school, as well as their upbringing within the framework of the communist ideology that prevailed in the country at that time. Such a plot has not previously been in the field of view of historians, which is why it requires study and comprehensive analysis. The numerous archival materials used in the article is being introduced into scientific circulation for the first time.Purpose – to study the experience of the joint work of the state and children's institutions for the subsequent integration of orphanages into Soviet society.Objectives. To identify and analyze the main directions of socialization of children in orphanages.Methodology. The research was based on the principles of objectivity, historicism and consistency, as well as general scientific methods of analysis and synthesis.Results. In the course of the conducted research, it was found out that it was possible to come to grips with the upbringing of state children only by the beginning of the 1930s. The chosen directions of socialization fit well into the historical context of the era. Instilling labor skills during vocational training was supposed to contribute to the demand for former orphanages at enterprises erected during industrialization, collective farms and state farms created during collectivization. Educational, extracurricular and cultural activities met the objectives of the cultural revolution and genuine communist education. Moreover, socialization was supposed to act as a subsequent social and professional elevator of the former orphanage resident.Conclusion. The efforts made by the state allowed some of the children deprived of parental care to get a start in life and take a worthy place in Soviet society.
Immersive Technologies for Depression Care: Scoping Review
Authors: Reategui-Rivera C Mahony , Villarreal-Zegarra David , De La Cruz-Torralva Kelly , Díaz-Sánchez Paquita , Finkelstein Joseph 
Published: March 2024

Background
Depression significantly impacts quality of life, affecting approximately 280 million people worldwide. However, only 16.5% of those affected receive treatment, indicating a substantial treatment gap. Immersive technologies (IMTs) such as virtual reality (VR) and augmented reality offer new avenues for treating depression by creating immersive environments for therapeutic interventions. Despite their potential, significant gaps exist in the current evidence regarding the design, implementation, and use of IMTs for depression care.

Objective
We aim to map the available evidence on IMT interventions targeting depression treatment.

Methods
This scoping review followed a methodological framework, and we systematically searched databases for studies on IMTs and depression. The focus was on randomized clinical trials involving adults and using IMTs. The selection and charting process involved multiple reviewers to minimize bias.

Results
The search identified 16 peer-reviewed articles, predominantly from Europe (n=10, 63%), with a notable emphasis on Poland (n=9, 56%), which contributed to more than half of the articles. Most of the studies (9/16, 56%) were conducted between 2020 and 2021. Regarding participant demographics, of the 16 articles, 5 (31%) exclusively involved female participants, and 7 (44%) featured participants whose mean or median age was >60 years. Regarding technical aspects, all studies focused on VR, with most using stand-alone VR headsets (14/16, 88%), and interventions typically ranging from 2 to 8 weeks, predominantly in hospital settings (11/16, 69%). Only 2 (13%) of the 16 studies mentioned using a specific VR design framework in planning their interventions. The most frequently used therapeutic approach was Ericksonian psychotherapy, used in 56% (9/16) of the studies. Notably, none of the articles reported using an implementation framework or identified barriers and enablers to implementation.

Conclusions
This scoping review highlights the growing interest in using IMTs, particularly VR, for depression treatment but emphasizes the need for more inclusive and comprehensive research. Future studies should explore varied therapeutic approaches and cost-effectiveness as well as the inclusion of augmented reality to fully realize the potential of IMTs in mental health care.
A detailed research on Antioxidant and therapeutic potential of Immuxanth implementing in silico and in vitro approach
Authors: Dutta Rajdeep Dutta Gopal , Kar Gautam , Rao Seema 
Published: March 2024

Imuuxanth powder, a dietary supplement enriched with natural antioxidants, is explored for its nutritional properties and potential health benefits. The powder provides 5.26 Kcal energy, 1.90g protein, zero fat and added sugar, and 1.80g fiber per serving. Suitable for low-calorie diets, it supports protein intake, tissue repair, and muscle development. With no fat or added sugar, it aids weight management and blood sugar control. Amino acid analysis highlights its diverse essential and non-essential amino acids. GC-MS identifies flavonoids, xanthones, and carotenoids for antioxidant properties.
Antioxidant assays (DPPH, FRAP, ABTS) confirm Imuuxanth's potential to combat oxidative stress. Molecular docking studies predict interactions with proteins related to antioxidant effects. Top berries intensify its antioxidant activity due to active compounds. Imuuxanth powder presents promising nutritional properties, including low energy, moderate protein, and absence of fat and added sugar. Its diverse bioactive compounds contribute to potent antioxidant capabilities. In silico studies support its potential as a dietary supplement for overall health, warranting further research for specific benefits.
Keywords: Immuxanth powder, Antioxandant potential, GCMS Analysis, Nutritional Analysis, Insilico Analysis
A Case Report of a Male with Systemic Lupus Erythematous with First Presentation of Annular Macular Itchy Rashes on his Extremities
Authors: Alouthmani Alyaa , ALakkad Ashraf , Ramli Samar , Eldegwy Marwa 
Published: March 2024

Background: Systemic lupus erythematosus (SLE) is an idiopathic autoimmune disease which impacts multiple organs and has various clinical presentations. Among all the organs, the skin is the most frequently affected.
Case Presentation: This case report presents a 34-year-old male who presented with severe, itchy, and painful rashes over his right arm and both legs, along with a history of pigmented skin lesions. Initially, the patient was given corticosteroid creams by a dermatologist, but the condition progressed, requiring further investigation. The patient's medical history revealed hypertension and, on review, signs of rashes, fatigue, and arthralgias were noted.
Physical examination indicated mild swelling and tenderness in both knees. Additionally, an examination revealed his skin was warm, he had fast capillary refill (<2 seconds), and he had an erythematic rash on the right arm and both legs. A nodular erythema rash was seen on the left leg, along with pigmented skin lesions on the right leg, including a bigger lesion measuring approximately 2.5 cm. Laboratory results indicated increased creatinine, low white blood cell count, anemia, and abnormal protein levels, raising doubts about SLE. Further tests confirmed a raised level of autoantibodies, low complement levels, and positive lupus-related antibodies.
Later, the patient was referred to a rheumatologist and an SLE diagnosis was confirmed based on laboratory results and hematological manifestations, mucocutaneous involvement, and lupus nephritis. Treatment initially started with hydroxychloroquine and prednisolone, then tests were repeated and the patient underwent a renal biopsy that revealed focal segmental glomerulosclerosis. He was again prescribed methylprednisolone and prednisolone for three days. The patient's condition resolved and he made a successful recovery.
Conclusion: This case demonstrates the multiple clinical manifestations of SLE, the necessity of in-depth investigations, and the requirement for multidisciplinary care to address the intricacies of organ involvement in the disease.