bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisis Aplikasi “ASN Memayu” Di Lingkungan Pemerintah Daerah Istimewa Yogyakarta
Authors: Taufan Taufan , Hidayat Muh Ryan Rahmatul 
Published: March 2024

Di era percepatan informasi Sistem Informasi Manajemen Kepegawaian sangat diperlukan sebagai pengolah administrasi pegawai dari lingkup kecil ke lingkup besar dalam konteks lingkungan pemerintahan. Dengan perkembangan dan kebutuhan yang semakin banyak mengakibatkan banyak perubahan dan regulasi dalam proses administrasi yang diharapkan dapat lebih efisien, efektif dan akurat dalam pengambilan keputusan dalam manajemen ASN. Tujuan dari penelitian ini adalah untuk menganalisis analisis aplikasi ASN Memayu di Lingkungan Pemerintah Provinsi Daerah Istimewa Yogyakarta, dan faktor pendukung penerapan digitalisasi system informasi kepegawaian Pemerintah Daerah Istimewa Yogyakarta. Metode penelitian ini adalah deskriptif kualitatif dengan pendekatan studi kepustakaan. Pengumpulan data menggunakan pengumpulan data dokumentasi berupa berita media massa, jurnal dan dokumen lainnya sesuai dengan tema. Analis data yang digunakan dengan mereduksi data, penyajian data dan menarik kesimpulan. Hasil penelitian menjelaskan bahwa Penerapan teknologi informasi dalam pengelolaan data kepegawaian di Pemerintah Provinsi Daerah Istimewa Yogyakarta, khususnya melalui aplikasi ASN Memayu, telah mengalami kemajuan yang signifikan. Perubahan mencerminkan tekad untuk meningkatkan efisiensi, keamanan, dan akurasi data. Pengembangan aplikasi ASN Memayu oleh Badan Kepegawaian Daerah Provinsi DIY merupakan langkah strategis dalam menyambut era digitalisasi, yang terwujud melalui rebranding sistem kepegawaian dan penggunaan teknologi digital. Tindakan progresif yang diambil BKD DIY membentuk dasar yang kuat untuk meningkatkan efektivitas, efisiensi, dan akuntabilitas dalam manajemen sumber daya manusia. Adopsi teknologi informasi dalam pengelolaan kepegawaian bukan hanya keharusan, melainkan juga manifestasi nyata dari komitmen untuk mencapai tata kelola yang baik dan pelayanan publik yang optimal melalui pemanfaatan teknologi informasi secara menyeluruh.
Asuhan Keperawatan Gerontik dengan Kasus Stroke di Panti Sosial Tresna Werdha Madago Tentena
Authors: Mapu Nurfaizah N.S , Agusrianto Agusrianto 
Published: March 2024

Latar belakang Lansia dengan umur 60 tahun keatas beresiko untuk mengalami berbagai macam penyakit degenerative termasuk salah satunya stroke. Lansia dengan stroke akan mengalami kondisi fisik seperti kelumpuhan, dan kesulitan dalam melakukan aktivitas sehari-hari. Asuhan keperawatan diberikan untuk mengatasi permasalahan yang dialami lansia stroke dan meningkatkan kenyamanan. Metode Penelitian: Metode yang digunakan adalah kualitatif dengan pendekatan studi kasus (case study). subyek study 1 orang lansia yang menderita stroke, dengan kesadaran komposmentis, berusia lebih dari 60 tahun, dan bersedia menjadi responden penelitian. Metode pengumpulan data yang digunakan yaitu metode wawancara, metode observasi, dan studi dokumentasi. Hasil Penelitian :Hasil pengkajian didapatkan data kelemahan ekstremitas sebelah kiri, susah memulai tidur, sering terbangun malam hari, riwayat jatuh, penglihatan kabur. Diagnosa yang ditegakan yaitu (1) gangguan mobilitas fisik berhubungan dengan penurunan kekuatan otot, (2) gangguan pola tidur berhubungan dengan kurang kontrol tidur, dan (3) risiko jatuh. Intervensi keperawatan yaitu teknik latihan penguatan sendi, terapi aktifitas, dukungan tidur, terapi musik, terapi pemijatan, dan pencegahan jatuh. Implementasi dilakukan selama 7 hari. Setelah dilakukan tindakan keperawatan masalah keperawatan teratasi dengan hasil kekuatan otot meningkat, kelemahan fisik menurun, sulit tidur menurun. dan risiko jatuh tidak terjadi. Kesimpulan: Penerapan asuhan keperawatan komprehensif pada pasien stroke dapat mengatasi masalah keperawatan yang dialami oleh pasien dan direkomendasikan kepada perawat atau petugas panti untuk memberikan ROM dan terapi aktifitas pada lansia yang mengalami stroke di Panti Sosial Tresna Werdha Madago Tentena.
Quantitative evaluation of motion compensation in post-stroke rehabilitation training based on muscle synergy
Authors: Liu Yanhong , Li Yaowei , Zhang Zan , Huo Benyan , Dong Anqin 
Published: March 2024

Introduction: Stroke is the second leading cause of death globally and a primary factor contributing to disability. Unilateral limb motor impairment caused by stroke is the most common scenario. The bilateral movement pattern plays a crucial role in assisting stroke survivors on the affected side to relearn lost skills. However, motion compensation often lead to decreased coordination between the limbs on both sides. Furthermore, muscle fatigue resulting from imbalanced force exertion on both sides of the limbs can also impact the rehabilitation outcomes.Method: In this study, an assessment method based on muscle synergy indicators was proposed to objectively quantify the impact of motion compensation issues on rehabilitation outcomes. Muscle synergy describes the body’s neuromuscular control mechanism, representing the coordinated activation of multiple muscles during movement. 8 post-stroke hemiplegia patients and 8 healthy subjects participated in this study. During hand-cycling tasks with different resistance levels, surface electromyography signals were synchronously collected from these participants before and after fatigue. Additionally, a simulated compensation experiment was set up for healthy participants to mimic various hemiparetic states observed in patients.Results and discussion: Synergy symmetry and synergy fusion were chosen as potential indicators for assessing motion compensation. The experimental results indicate significant differences in synergy symmetry and fusion levels between the healthy control group and the patient group (p ≤ 0.05), as well as between the healthy control group and the compensation group. Moreover, the analysis across different resistance levels showed no significant variations in the assessed indicators (p &gt; 0.05), suggesting the utility of synergy symmetry and fusion indicators for the quantitative evaluation of compensation behaviors. Although muscle fatigue did not significantly alter the symmetry and fusion levels of bilateral synergies (p &gt; 0.05), it did reduce the synergy repeatability across adjacent movement cycles, compromising movement stability and hindering patient recovery. Based on synergy symmetry and fusion indicators, the degree of bilateral motion compensation in patients can be quantitatively assessed, providing personalized recommendations for rehabilitation training and enhancing its effectiveness.
Lipoprotein(a) as a risk factor for atherosclerotic cardiovascular disease in patients in non-metropolitan areas of Brandenburg, Germany
Authors: Hillmeister Philipp , Li Kangbo , Dai Mengjun , Sacirovic Mesud , Pagonas Nikolaos , Ritter Oliver , Bramlage Peter , Bondke Persson Anja , Buschmann Ivo , Zemmrich Claudia 
Published: March 2024

Background and aimsIn the non-metropolitan region of Brandenburg (Germany), which is characterized by high rates of cardiovascular diseases and underserved medical care, there is a lack of awareness regarding lipoprotein(a) [Lp(a)] as a risk factor. In addition, data from patients with atherosclerotic cardiovascular disease (ASCVD) in diverse regional backgrounds, including the understudied Brandenburg cohort, and various healthcare statuses remain insufficient.MethodsIn this WalkByLab study, Lp(a) levels were monitored in a non-metropolitan cohort (n = 850) in Brandenburg, Germany, comprising 533 patients at high cardiovascular risk and 317 healthy controls. Patients underwent a comprehensive angiological screening, which included blood serum analysis, assessment of medical and family history, cardiovascular risk, and disease status, and evaluation of lifestyle and quality of life. All parameters were evaluated with regard to two groups based on Lp(a) levels: low (&lt;50 mg/dl) and high (≥50 mg/dl).ResultsBrandenburg patients with cardiovascular diseases showed higher Lp(a) levels than healthy controls (24.2% vs. 14.8%, p = 0.001). Logistic regression analysis with different characteristics revealed that Lp(a) was an independent risk factor significantly associated with ASCVD (OR 2.26, 95% CI 1.32–3.95, p = 0.003). The high-Lp(a) group showed a higher proportion of patients with coronary artery disease, peripheral artery disease, or cerebrovascular disease compared to the low-Lp(a) group (50% vs. 36.8%; 57.7% vs. 45.8%; 17.6% vs. 9.2%; p = 0.004); also, a higher percentage of patients in the high-Lp(a) group had heart failure (72.8% vs. 53.2%, p = 0.014) and myocardial infarction (24.7% vs. 13.9%, p = 0.001). The high-Lp(a) group exhibited higher rates of statins (63.1% vs. 50.4%, p = 0.003), ezetimibe (14.8% vs. 5.5.%, p = 0.001), and beta-blockers (55.7% vs. 40.7%, p = 0.001) use. Lp(a) levels were found to be independent of physical activity or smoking behavior and did not change over time (12 months).ConclusionsOur study highlights the significance of elevated Lp(a) levels in Brandenburg cardiovascular patients and identifies them as an independent risk factor for ASCVD, which has implications for addressing cardiovascular health of non-metropolitan populations.
The heart-mind relationship in women cardiovascular primary prevention: the role of depression, anxiety, distress and Type-D personality in the 10-years cardiovascular risk evaluation
Authors: Giuliani Mattia , Santagostino Baldi Giulia , Capra Nicolò , Bonomi Alice , Marzorati Chiara , Sebri Valeria , Guiddi Paolo , Montorsi Piero , Pravettoni Gabriella , Trabattoni Daniela 
Published: March 2024

IntroductionCardiovascular diseases are the leading cause of death among women. Prevention programmes underscore the need to address women-specific risk factors. Additionally, mental well-being is a significant aspect to consider when grappling with cardiovascular disease in women, particularly depression, anxiety, distress, and personality traits. This study aimed to create “at-risk” psychological profiles for women without prior cardiovascular disease history and to evaluate the association between anxiety, depression, distress, and Type-D personality traits with increased cardiovascular risk over 10 years.Methods219 women voluntarily participated in the “Monzino Women's Heart Centre” project for primary prevention and early diagnosis of cardiovascular diseases. Psychological profiles were developed utilising cluster analysis.ResultsThe primary finding indicating that belonging to the “at-risk” psychological cluster was associated with a surge in the 10-year cardiovascular risk prediction score, despite the number of comorbid risk factors (Psychological “at-risk” cluster: β = .0674; p = .006; Risk factors: β = .0199; p = .242).ConclusionsThis finding suggests that psychological well-being of women should be assessed from the very beginning of cardiovascular prevention programmes.
Adopting a reductionist approach to advance acoustic deterrents in fish conservation
Authors: Holgate Amelia , White Paul R. , Leighton Timothy G. , Kemp Paul 
Published: March 2024

IntroductionDeterrents that use acoustics to guide fish away from dangerous areas (e.g., water intakes) depend on the elicitation of avoidance in the target species. Background noise is often neglected when testing acoustic deterrents, but it is important to account for its effects as freshwater environments present a wide variety of ambient soundscapes.MethodsUsing the widely studied goldfish (Carassius auratus) as a suitable experimental model, this study adopted a reductionist approach to investigate the relationship between the startle response to a pure tone signal and background noise. Under laboratory conditions, the startle responses of individual goldfish exposed to 120 ms tones at 250 Hz and four Sound Pressure Levels (SPLs: 115, 125, 135, 145 dB re 1 μPa) were quantified in the presence (treatment) and absence (ambient - control) of band-limited random noise (105 dB re 1 μPa).Results and discussionWhen observing the dose-response relationship, the proportion of fish that startled to the signal increased with SPL in both the treatment and control, although there was no difference between them, suggesting that the signal-to-noise ratio was not influential under the conditions tested. However, further analysis using Signal Detection Theory indicated that the was higher in the noisy treatment than the control when responding to both false alarms (startle during a pre-signal period) and hits (startle to an external stimulus during the pre-signal period). Furthermore, fish were better able to discriminate (d?) external stimuli over time (during the pre-signal period) in the treatment than control. There is a need to consider the role of background noise when designing acoustic fish deterrents that depend on the exhibition of avoidance behaviors.
The collateral damage of the COVID-19 pandemic on homeless people in the Netherlands; a qualitative study on the impact of health and care
Authors: van Loenen Tessa , Sow Jeyna , van den Muijsenbergh Maria 
Published: March 2024

IntroductionPeople experiencing homelessness, also in the Netherlands, experience poorer physical and mental health compared to the general population and suffer from unmet health needs that are strongly related to their unfavorable social situation. This makes them especially vulnerable to negative consequences of a public health emergency such as the COVID-19 pandemic. This qualitative study aims to provide insight into the experiences of people experiencing homelessness with the impact of the pandemic on their health and lives.MethodsWe performed semistructured interviews at 3 different times in the first 2 years of the pandemic including, respectively, 67, 55, and 53 persons. Interviews focused on their experienced mental and physical health, their experiences with the public health measures taken, and the care they received during the pandemic.ResultsIn each round of interviews, the self-reported mental health was lower than before. In the last round approximately half felt mentally unhealthy. Mental health was negatively impacted due to livelihood insecurity, loss of social contact and poor accessibility to social and medical care. Twenty-four hour shelter locations with smaller dormitories had a positive impact on mental health.Conclusion and recommendationsMost preventive measures taken during the pandemic negatively impacted the mental health of people experiencing homelessness but some improved their health. We recommend special attention to the effects on mental health when planning measures for pandemic control and we recommend to implement 24-h shelter and smaller dormitories.
Anion exchange HPLC monitoring of mRNA in vitro transcription reactions to support mRNA manufacturing process development
Authors: Welbourne Emma N. , Loveday Kate A. , Nair Adithya , Nourafkan Ehsan , Qu Jixin , Cook Ken , Kis Zoltán , Dickman Mark J. 
Published: March 2024

mRNA technology has recently demonstrated the ability to significantly change the timeline for developing and delivering a new vaccine from years to months. The potential of mRNA technology for rapid vaccine development has recently been highlighted by the successful development and approval of two mRNA vaccines for COVID-19. Importantly, this RNA-based approach holds promise for treatments beyond vaccines and infectious diseases, e.g., treatments for cancer, metabolic disorders, cardiovascular conditions, and autoimmune diseases. There is currently significant demand for the development of improved manufacturing processes for the production of mRNA therapeutics in an effort to increase their yield and quality. The development of suitable analytical methods for the analysis of mRNA therapeutics is critical to underpin manufacturing development and the characterisation of the drug product and drug substance. In this study we have developed a high-throughput, high-performance liquid chromatography (HPLC) workflow for the rapid analysis of mRNA generated using in vitro transcription (IVT). We have optimised anion exchange (AEX) HPLC for the analysis of mRNA directly from IVT. Chromatography was performed in under 6 min enabling separation of all of the key components in the IVT, including nucleoside triphosphates (NTPs), Cap analogue, plasmid DNA and mRNA product. Moreover, baseline separation of the NTPs was achieved, which facilitates accurate quantification of each NTP such that their consumption may be determined during IVT reactions. Furthermore, the HPLC method was used to rapidly assess the purification of the mRNA product, including removal of NTPs/Cap analogue and other contaminants after downstream purification, including solid phase extraction (SPE), oligo deoxythymidine (oligo-dT) affinity chromatography and tangential flow filtration (TFF). Using the developed method excellent precision was obtained with calibration curves for an external mRNA standard and NTPs giving correlation coefficients of 0.98 and 1.0 respectively. Intra- and inter-day studies on retention time stability of NTPs, showed a relative standard deviation ≤ 0.3% and ≤1.5% respectively. The mRNA retention time variability was ≤0.13%. This method was then utilised to monitor the progress of an IVT reaction for the production of Covid spike protein (C-Spike) mRNA to measure the increasing yield of mRNA alongside the consumption of NTPs during the reaction.
Coherent activity within and between hemispheres: cortico-cortical connectivity revealed by rTMS of the right posterior parietal cortex
Authors: Mazzi Chiara , Mele Sonia , Bagattini Chiara , Sanchez-Lopez Javier , Savazzi Silvia 
Published: March 2024

IntroductionLow frequency (1 Hz) repetitive transcranial stimulation (rTMS) applied over right posterior parietal cortex (rPPC) has been shown to reduce cortical excitability both of the stimulated area and of the interconnected contralateral homologous areas. In the present study, we investigated the whole pattern of intra- and inter-hemispheric cortico-cortical connectivity changes induced by rTMS over rPPC.MethodsTo do so, 14 healthy participants underwent resting state EEG recording before and after 30 min of rTMS at 1 Hz or sham stimulation over the rPPC (electrode position P6). Real stimulation was applied at 90% of motor threshold. Coherence values were computed on the electrodes nearby the stimulated site (i.e., P4, P8, and CP6) considering all possible inter- and intra-hemispheric combinations for the following frequency bands: delta (0.5–4 Hz), theta (4–8 Hz), alpha (8–12Hz), low beta (12–20 Hz), high beta (20–30 Hz), and gamma (30–50 Hz).Results and discussionResults revealed a significant increase in coherence in delta, theta, alpha and beta frequency bands between rPPC and the contralateral homologous sites. Moreover, an increase in coherence in theta, alpha, beta and gamma frequency bands was found between rPPC and right frontal sites, reflecting the activation of the fronto-parietal network within the right hemisphere. Summarizing, subthreshold rTMS over rPPC revealed cortico-cortical inter- and intra-hemispheric connectivity as measured by the increase in coherence among these areas. Moreover, the present results further confirm previous evidence indicating that the increase of coherence values is related to intra- and inter-hemispheric inhibitory effects of rTMS. These results can have implications for devising evidence-based rehabilitation protocols after stroke.
Efficacy and safety of pembrolizumab as first-line treatment for advanced non-small cell lung cancer complicated with chronic obstructive pulmonary disease: protocol for a prospective, single-arm, single-center, phase II clinical trial
Authors: Dong Weigang , Yin Yan , Liu Bin , Jiang Yan , Wang Lei , Shi Dongsheng , Qin Jianwen 
Published: March 2024

BackgroundThe first-line standard treatment option for patients with NSCLC complicated with Chronic obstructive pulmonary disease (COPD) is still unclear and relies on the treatment option of NSCLC alone. To date, a limited number of retrospective studies have explored the efficacy and safety of immunotherapy in patients with NSCLC complicated with COPD. We therefore designed this study to further explore the efficacy and safety of first-line immunotherapy in patients with NSCLC complicated with COPD.MethodsThis study was designed as a single-armed, single-center, prospective, phase II clinical study. It will include 30 advanced (stage IV) NSCLC combined with COPD primary treatment subjects. Each subject’s diagnosis will be confirmed by clinical, radiographic, pathologic, and pulmonary function evaluation. A fixed dose of 200 mg pembrolizumab will be administered by intravenous infusion on day1 every 3 weeks (Q3W). The management of stable and acute exacerbations of COPD include home oxygen therapy, and the use of conventional medications are also administered. Imaging evaluation will be performed every 6 weeks for 6 months from the first pembrolizumab dose and approximately every 12 weeks thereafter until disease progression or early withdrawal. COPD status will be evaluated every 3 months by pulmonary function, GOLD grading, mMRC score, CAT score, ABCD grouping, and AECOPD severity. The primary outcome is Progression-free survival. The secondary outcome measures include objective response rate, overall survival, rate of acute exacerbations of COPD (times/year), lung function, mMRC score, CAT score, impact of treatment on patient’s health-related quality of life, antibiotic use (including duration and classes), and adverse events associated with immune checkpoint inhibitors. Exploratory endpoint is to explore the association between COPD grade and the degree of immune cell (CD4+ T lymphocytes and CD8+ T lymphocytes) infiltration, as well as the association between COPD grade and the efficacy of immune checkpoint inhibitors.Clinical trial registrationClinicalTrials.gov, identifier NCT05578222.
Risk factors of paclitaxel-induced peripheral neuropathy in patients with breast cancer: a prospective cohort study
Authors: Lixian Sun , Xiaoqian Yu , Luyan Guo , Lizhi Zhou , Rui Du , Hongyue Yao , Caijie Zhao , Fenghui Yuan 
Published: March 2024

ObjectiveChemotherapy-induced peripheral neuropathy (CIPN) is a common and severe adverse reaction in taxane-based chemotherapy. This study aimed to analyze the risk factors of peripheral neuropathy in patients with breast cancer receiving paclitaxel chemotherapy to provide a reference for the early prevention of CIPN.MethodsWe included 350 patients with breast cancer who received chemotherapy for the first time at the Tangshan People’s Hospital between August 2022 and June 2023 and were followed for at least 3 months after the end of chemotherapy. The incidence of CIPN in patients with breast cancer was calculated, and risk factors for CIPN were analyzed using logistic regression analysis.ResultsThe incidence rate of CIPN was 79.1%. Multifactor logistic regression analysis indicated that age ≥45 years [odds ratio (OR)=5.119, 95% confidence interval (CI)=1.395–18.780] and ≥60 years (OR=9.366, 95% CI=1.228–71.421), history of hypertension (OR=3.475, 95% CI=1.073–11.250), cumulative dose of chemotherapy drugs &gt;900 mg (OR=4.842, 95% CI=1.961–5.946), vitamin D deficiency (OR=6.214, 95% CI=2.308–16.729), abnormal alanine aminotransferase (OR=3.154, 95% CI=1.010–9.844), anemia before chemotherapy (OR=2.770, 95% CI=1.093–7.019), infusion duration of chemotherapy drugs &gt;30 min (OR=3.673, 95% CI=1.414–9.539), body mass index ≥24 kg/m2 (OR=8.139, 95% CI=1.157–57.240), mild depression (OR=4.546, 95% CI=1.358–15.223), and major depression (OR=4.455, 95% CI=1.237–16.037) increased the risk of CIPN. Having a regular caregiver (OR=0.223, 95% CI=0.087–0.573), high levels of physical activity (OR=0.071, 95% CI=0.008–0.647), and strong social support (OR=0.048, 95% CI=0.003–0.682) were protective factors against CIPN.ConclusionClinical attention should be paid to patients with these risk factors, and active and effective preventive measures should be taken to reduce the occurrence of CIPN and improve the quality of life.