bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Country of Shepherds
Authors: Myers Kathleen Ann 
Published: March 2024

This book draws on the life stories told by shepherds, farmers, and their families in the Andalusian region in Spain to sketch out the landscapes, actions, and challenges of people who work in pastoralism. Their narratives highlight how local practices interact with regional and European communities and policies, and they help us see a broader role for extensive grazing practices and sustainability.
A Country of Shepherds is timely, reflecting the growing interest in ecological farming methods as well as the Spanish government’s recent work with UNESCO to recognise the seasonal movement of herd animals in the Iberian Peninsula as an Intangible Cultural Heritage.
Demonstrating the critical role of tradition, cultural geographies, and sustainability in the Mediterranean, this book will appeal to academicians but also to general readers who seek to understand, in very human terms, the impact of the world-wide environmental crisis we are now experiencing.
How Much Does Land–Atmosphere Coupling Influence Summertime Temperature Variability in the Western United States?
Authors: Zeppetello Lucas R. Vargas , Zhang Lily N. , Battisti David S. , Laguë Marysa M. 
Published: March 2024

Abstract
Interannual fluctuations in average summertime temperatures across the western United States are captured by a leading empirical orthogonal function that explains over 50% of the total observed variance. In this paper, we explain the origins of this pattern of interannual temperature variability by examining soil moisture–temperature coupling that acts across seasons in observations and climate models. We find that a characteristic pattern of coupled temperature–soil moisture climate variability accounts for 34% of the total observed variance in summertime temperature across the region. This pattern is reproduced in state-of-the-art global climate models, where experiments that eliminate soil moisture variability reduce summertime average temperature variance by a factor of 3 on average. We use an idealized model of the coupled atmospheric boundary layer and underlying land surface to demonstrate that feedbacks between soil moisture, boundary layer relative humidity, and precipitation can explain the observed relations between springtime soil moisture and summertime temperature. Our results suggest that antecedent soil moisture conditions and subsequent land–atmosphere interactions play an important role in interannual summertime temperature variability in the western United States; soil moisture variations cause distal temperature anomalies and impart predictability at time scales longer than one season. Our results indicate that 40% of the observed warming trend across the western United States since 1981 has been driven by wintertime precipitation trends in the U.S. southwest.

Significance Statement
Year-to-year fluctuations in summertime temperatures have a large impact on drought, wildfire, and extreme heat across the Western United States. We find strong evidence that soil moisture deficits in the preceding spring may be the primary driver of higher-than-average summer temperatures in this region. Our results suggest that memory in the water cycle may lead to greater predictability in the climate system from season to season and that trends in southwest precipitation have exerted a considerable influence on observed warming over the past 40 years.
Do immigrants support environmentalism? – Immigrants’ environmental socialization in the United States
Authors: Sun Skylar Biyang , Zhao Xiaohang 
Published: March 2024

As globalisation continues, heated debates over immigrants’ environmental behaviours in the U.S. have been prominent in recent years. While research has generally focused on the association between political affiliation and pro-environmental values, only a few studies have specifically explored immigrants’ pro-environmental values in the U.S. Utilizing a pooled dataset spanning 3 years (2017, 2020, and 2022) from the Cooperative Election Study and employing a multilevel model, we empirically tested three hypotheses regarding immigrants’ pro-environmental attitudes: the globalization hypothesis, the prosperity hypothesis, and the political socialization hypothesis. Our results supported all three hypotheses. On average, immigrants exhibited higher environmental scores than the native-born population. In addition, we identified generational differences, with the 1st generation immigrants showing the highest environmental scores, while the 2nd generation immigrants fell between the 1st generation and the native-born. Compared to the native-born population, party affiliation played a smaller role in immigrants’ formation of pro-environmental values. Democratic immigrants tended to be less pro-environment than democratic locals, while Republican immigrants were more pro-environment than Republican locals.
Diagnostic Aspects of Paraquat in the Forensic Toxicology: A Systematic Review
Authors: Reihani Amin , Marboutian Farangis , Aghebat–bekheir Saeed , Reyhani Arezoo , Akhgari Maryam 
Published: March 2024

Background: Paraquat (N, N-dimethyl-4,4-bipyridinium dichloride) is a nonselective, fast-acting, and contact chemical herbicide used extensively for weed control. It has high acute oral toxicity, the ability to accumulate in the lungs, and a high potential for pulmonary fibrosis after its intoxication. The present systematic review focuses on evaluating diagnostic aspects of paraquat (PQ) in forensic toxicology. Methods: Evaluation of the literature according to the following criteria: only human studies published from February 1971 to March 2022 which are in English on the following databases: 1) Medline/PubMed/MeSH search words: ((Methyl viologen [Title/Abstract]) OR (paraquat [MeSH Terms])) AND (forensic [Title/Abstract]); 2) Scopus Keywords related to the study aim included forensic toxicology, paraquat, Methyl viologen; 3) Web of Science. Keywords related to the study aim included forensic toxicology, paraquat, and Methyl viologen. Results: Thirty full-text articles were included. The results of our review indicate plasma and urine are more used for identifying PQ, and liver, lung, and gastric fluid are important in postmortem cases. Preparation methods, including liquid-liquid extraction (LLE), solid-phase extraction, and acetonitrile-precipitated protein, are often required for removing interfering substances. Chromatographic methods, among other analytical techniques, are more sensitive, specific, and applicable. Conclusion: Our review suggests that plasma, urine, and lungs should be prioritized in sampling. Solid-phase extraction has better recovery than LLE in many samples. Colorimetric methods are not used much today, and radioimmunoassay (RIA) has limited application despite its high sensitivity. Gas and liquid chromatography methods appear to offer the best approach for the analysis of PQ.
Comparison of Clinical Efficacy and Mechanical Characteristics of Two Knee Distraction Devices With Relevance for Clinical Practice
Authors: Struik T. , Jansen M.P. , Lafeber R.G.P. ,   Distraction Study Group, Lafeber F.P.J.G. , Mastbergen S.C. 
Published: March 2024

Objective Distraction treatment for severe osteoarthritis below the age of 65 successfully postpones arthroplasty. Most patients have been treated with a general external fixator or a device specifically intended for knee distraction. This study compares clinical efficacy of both devices in retrospect and their mechanical characteristics. Design Clinical efficacy 2 years posttreatment was compared using retrospective data from patients with severe knee osteoarthritis treated with knee distraction; 63 with the Dynamic Monotube (Stryker GmbH, Switzerland) and 65 with the KneeReviver (ArthroSave BV, the Netherlands). Changes in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain, stiffness, and function, general well-being (SF-36), cartilage thickness by radiographic joint space widening, and adverse events during treatment were assessed. Axial stiffness of clinically feasible configurations was assessed by bench testing for the Dynamic Monotube triax system and the KneeReviver. Results No differences were observed in clinical efficacy, nor in mechanical characteristics and adverse events between the two devices. Although with large variation, both showed a clinically relevant improvement. In mechanical testing, contact between articular surfaces was observed for both devices at physiological loading. Stiffness of applied configurations strongly varied and primarily depended on bone pin length. Conclusions Patients treated with a general intended-use device or a distraction-specific device both experienced clinical and structural efficacy although with significant variation between patients. The latter may be the result of varying mechanical characteristics resulting from differences in clinical configurations of the devices and actual loading. The exact role of full/partial mechanical unloading of the joint during distraction treatment remains unclear.
Surgical Management of Osteochondritis Dissecans of the Glenoid via Autologous Bone Marrow Aspirate Concentrate and Extracellular Matrix Graft in an Eighteen-Year-Old College Pitcher
Authors: Tingey Mitchell T. , Glover Mark A. , St. Jeor Jeffery D. , Trasolini Nicholas A. , Albertson Benjamin S. , Fiegen Anthony P. , Waterman Brian R. 
Published: March 2024

Background: Osteochondritis dissecans (OCD) affects the shoulder in only 0.6% of patients aged 2 to 19 years with disease most commonly in the humeral head. When the glenoid is affected, it is often in male overhead throwing athletes and treated with fixation via autologous osteochondral plugs following bone marrow aspirate. Indications: The primary indication for surgical management of OCD is failure of conservative management, often with imaging showing disruption of the glenoid subchondral plate. This patient is an 18-year-old male pitcher with over 2 years of chronic, deep-seated shoulder pain unresponsive to conservative management. Technique Description: We present a primary arthroscopic technique of autologous bone marrow aspirate concentrate graft for management of OCD in an 18-year-old college baseball pitcher. The patient was placed in the left lateral decubitus position with an axillary roll and standard portals were established. A loose fragmented flap with no underlying osseous material was debrided and a 3-cm central area of bony loss was identified. Bone marrow aspirate of 80 mL was taken from the anterior superior iliac crest. The aspirate was mixed with Biocartilage (Arthrex) to fill the defect flush with the surrounding tissue and sealed with fibrin glue. Ports were closed and an abduction sling was applied. Results: A recent review article demonstrated that athletes who underwent surgical management of OCD lesions returned to sports an average of 1.2 months sooner than those managed non-operatively, though this difference was not significant. This patient had a full return to play at 9 months. At 1-year follow-up, he made a full recovery and is currently playing professionally without shoulder pain. Discussion/Conclusion: Autologous bone marrow aspirate defect filling is a viable treatment of OCD, even in high-level overhead throwing athletes. It allows for arthroscopic treatment with long-term success in the treatment of pain and function. Patient Consent Disclosure Statement: The author(s) attests that consent has been obtained from any patient(s) appearing in this publication. If the individual may be identifiable, the author(s) has included a statement of release or other written form of approval from the patient(s) with this submission for publication.
Genome-wide analysis of plant specific YABBY transcription factor gene family in carrot (Dacus carota) and its comparison with Arabidopsis
Authors: Hussain Mujahid , Javed Muhammad Mubashar , Sami Adnan , Shafiq Muhammad , Ali Qurban , Mazhar Hafiz Sabah-Ud-Din , Tabassum Javaria , Javed Muhammad Arshad , Haider Muhammad Zeeshan , Hussain Muhammad , Sabir Irfan Ali , Ali Daoud 
Published: March 2024

AbstractYABBY gene family is a plant-specific transcription factor with DNA binding domain involved in various functions i.e. regulation of style, length of flowers, and polarity development of lateral organs in flowering plants. Computational methods were utilized to identify members of the YABBY gene family, with Carrot (Daucus carota) ‘s genome as a foundational reference. The structure of genes, location of the chromosomes, protein motifs and phylogenetic investigation, syntony and transcriptomic analysis, and miRNA targets were analyzed to unmask the hidden structural and functional characteristics YABBY gene family in Carrots. In the following research, it has been concluded that 11 specific YABBY genes irregularly dispersed on all 9 chromosomes and proteins assembled into five subgroups i.e. AtINO, AtCRC, AtYAB5, AtAFO, and AtYAB2, which were created on the well-known classification of Arabidopsis. The wide ranges of YABBY genes in carrots were dispersed due to segmental duplication, which was detected as prevalent when equated to tandem duplication. Transcriptomic analysis showed that one of the DcYABBY genes was highly expressed during anthocyanin pigmentation in carrot taproots. The cis-regulatory elements (CREs) analysis unveiled elements that particularly respond to light, cell cycle regulation, drought induce ability, ABA hormone, seed, and meristem expression. Furthermore, a relative study among Carrot and Arabidopsis genes of the YABBY family indicated 5 sub-families sharing common characteristics. The comprehensive evaluation of YABBY genes in the genome provides a direction for the cloning and understanding of their functional properties in carrots. Our investigations revealed genome-wide distribution and role of YABBY genes in the carrots with best-fit comparison to Arabidopsis thaliana.
Loss of chromosome Y in regulatory T cells
Authors: Mattisson Jonas , Halvardson Jonatan , Davies Hanna , Bruhn-Olszewska Bożena , Olszewski Paweł , Danielsson Marcus , Bjurling Josefin , Lindberg Amanda , Zaghlool Ammar , Rychlicka-Buniowska Edyta , Dumanski Jan P. , Forsberg Lars A. 
Published: March 2024

Abstract
Background
Mosaic loss of chromosome Y (LOY) in leukocytes is the most prevalent somatic aneuploidy in aging humans. Men with LOY have increased risks of all-cause mortality and the major causes of death, including many forms of cancer. It has been suggested that the association between LOY and disease risk depends on what type of leukocyte is affected with Y loss, with prostate cancer patients showing higher levels of LOY in CD4 + T lymphocytes. In previous studies, Y loss has however been observed at relatively low levels in this cell type. This motivated us to investigate whether specific subsets of CD4 + T lymphocytes are particularly affected by LOY. Publicly available, T lymphocyte enriched, single-cell RNA sequencing datasets from patients with liver, lung or colorectal cancer were used to study how LOY affects different subtypes of T lymphocyte. To validate the observations from the public data, we also generated a single-cell RNA sequencing dataset comprised of 23 PBMC samples and 32 CD4 + T lymphocytes enriched samples.

Results
Regulatory T cells had significantly more LOY than any other studied T lymphocytes subtype. Furthermore, LOY in regulatory T cells increased the ratio of regulatory T cells compared with other T lymphocyte subtypes, indicating an effect of Y loss on lymphocyte differentiation. This was supported by developmental trajectory analysis of CD4 + T lymphocytes culminating in the regulatory T cells cluster most heavily affected by LOY. Finally, we identify dysregulation of 465 genes in regulatory T cells with Y loss, many involved in the immunosuppressive functions and development of regulatory T cells.

Conclusions
Here, we show that regulatory T cells are particularly affected by Y loss, resulting in an increased fraction of regulatory T cells and dysregulated immune functions. Considering that regulatory T cells plays a critical role in the process of immunosuppression; this enrichment for regulatory T cells with LOY might contribute to the increased risk for cancer observed among men with Y loss in leukocytes.
The mediating effect of family resilience between coping styles and caregiver burden in maintenance hemodialysis patients: a cross-sectional study
Authors: Zhang Qianjun , Liu Qiaoling , Zhang Li , Jin Yabin , Xiang Xia , Huang Xuefang , Mai Jiezhen , Zhao Tingfen , Cui Wen 
Published: March 2024

Abstract
Background
Primary caregivers of hemodialysis patients suffer from varying degrees of stress from their patients. Caring for hemodialysis patients can expose caregivers to many problems, leading to an increased burden of care and even impacting the quality of care. The purpose of our study was to examine whether family resilience could be a mediating variable moderating the relationship between patient coping styles and caregiver burden.

Methods
The study was a cross-sectional and descriptive-analytical study that interviewed 173 pairs of hemodialysis patients and their caregivers at a blood purification center in a public hospital in China. The Brief Coping Styles Scale (Chinese version) was used to assess individuals’ coping styles for disease and treatment. From the caregiver’s perspective, the Family Resilience Assessment Scale (Chinese version) was used to understand the resilience of families, and the Zarit Caregiver Burden Scale was used to capture the caregiver’s subjective experience of burden. Statistical analyses were conducted using SPSS version 23 and Amos version 26 to analyze the relationships between variables to examine for correlation and construct mediated effects models.

Results
Coping styles showed a significant positive correlation with family resilience (r = 0.347, P < 0.01) and a negative correlation with caregiver burden (r = -0.379, P < 0.01). A significant negative correlation was found between family resilience and caregiver burden (r = -0.503, P < 0.01). In the mediation model, patient coping styles directly impacted caregiver burden significantly (95% CI [-0.372, -0.058]), and coping styles indirectly impacted caregiver burden by family resilience in a significant way (95% CI [-0.275, -0.098]).

Conclusions
Patient coping styles directly affect caregiver burden. Family resilience is a mediating variable between patients’ coping styles and the burden on caregivers.
Prevalence of perceived discrimination, determinants and associations with self-rated general and sexual health, healthcare utilization and self-perceived integration: a cross-sectional survey of migrants in Sweden
Authors: Nkulu Kalengayi Faustine Kyungu , Baroudi Mazen , Hurtig Anna-Karin 
Published: March 2024

Abstract
Background
Sweden has welcomed migrants, but attitudes have shifted, becoming hostile due to populism and the growing number of migrants. This has left migrants feeling unwelcome and marginalized. Few studies have examined the extent to which migrants perceive discrimination, who, why, where and its relationships with different outcomes. This study has two aims: to assess the prevalence, reasons, and determinants of perceived discrimination among migrants (1) and its associations with self-rated health, sexual health, healthcare use, and integration (2).

Methods
We analysed data from a 2018 survey on migrants’ sexual and reproductive health and rights. The survey included 1740 migrants aged 16 or older. We used descriptive and log-binomial regression analyses to estimate prevalence, crude and adjusted prevalence ratios (APR) with 95% confidence interval (CI).

Results
About 36% of participants perceived discrimination in Sweden, with ethnic origin (62%) and religion (35%) as main reasons. Perceived discrimination occurred in public spaces (47%), schools (33%), internet (20%), work (19%), public services (18%), residential areas (16%), and healthcare settings (10%). Migrant men (APR: 1.26, CI:1.07–1.49), born in Middle East and North Africa (APR: 1.57, CI:1.26–1.95) and South Asia (APR: 1.61, CI:1.27–2.04) regions, with more than 12 years of education (APR: 1.33, CI:1.10–1.60), a non-heterosexual orientation (APR: 1.21, CI: 1.02–1.43), a non-Christian religion (APR: 1.41, CI: 1.10–1.80), economic stress (APR:1.67, CI: 1.44–1.93) or Swedish language skills (APR: 1.24, CI:1.07–1.43) perceived discrimination more than their counterparts. In contrast, the oldest participants (46 years or more) perceived less discrimination (APR:0.55, CI: 0.37–0.80) than the youngest ones (16–25 years). Moreover, perceived discrimination was associated with poor self-rated general (APR:1.72, CI: 1.45–2.04) and sexual health (APR:1.40, CI:1.2–1.64), integration (APR:1.25, CI:1.14–1.37), and healthcare access (APR: 1.48, 1.16–1.89).

Conclusions
This study shows that migrants in Sweden face widespread perceived discrimination based on ethnicity and religion. This can affect their health, healthcare use, and social integration. The study calls for policies and interventions that tackle systemic perceived discrimination, foster inclusion, and guarantee equal opportunities in accessing healthcare and resources for migrants. It also urges support for vulnerable groups who perceive more discrimination, such as migrants from certain regions or under economic stress.
Contribution of small airway inflammation to the development of COPD
Authors: Li Li , Gong Ying , Hou Dongni , Song Yijun , Bi Jing , Li Miao , Han Junjie , Song Yuanlin , She Jun 
Published: March 2024

Abstract
Background
Little attention has been paid to the pathophysiological changes in the natural history of chronic obstructive pulmonary disease (COPD). The destructions of the small airways were visualized on thoracic micro-computed tomography scan. We investigated whether small airway inflammation (SAI) was the risk for the development of COPD.

Methods
A total of 1062 patients were enrolled and analyzed in the study. The partitioned airway inflammation was determined by exhaled nitric oxide (NO) of FnNO, FeNO50, FeNO200, and calculated CaNOdual. Both FeNO200 and CaNOdual were compared to detect the promising predictor for peripheral airway/alveolar inflammation in COPD. The correlation between exhaled NO and white cell classification was evaluated to determine the inflammation type during the development of COPD.

Results
Exhaled NO levels (FnNO, FeNO50, FeNO200, and CaNOdual) were the highest in the COPD group compared with all other groups. Furthermore, compared with controls, exhaled NO levels (FeNO50, FeNO200, and CaNOdual) were also significantly higher in the emphysema, chronic bronchitis, and smoking groups. FeNO200 was found to be a promising predictor for peripheral airway/alveolar inflammation (area under the curve [AUC] of the receiver operating characteristic [ROC] curve, area under the curve [AUC] = 0.841) compared with CaNOdual (AUC ROC = 0.707) in COPD. FeNO200 was the main risk factor (adjusted odds ratio, 2.191; 95% CI, 1.797–2.671; p = 0.002) for the development of COPD. The blood eosinophil and basophil levels were correlated with FeNO50 and FeNO200.

Conclusion
The complete airway inflammations were shown in COPD, whereas SAI was the main risk factor for the development of COPD, which might relate to eosinophil and basophil levels.