bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deutsche Vergleichsportale für Hebammensuche: ein hilfreiches Entscheidungsinstrument für Schwangere?
Authors: Kast Kristina , Oderbein Anja , Karch Julia , Schöffski Oliver 
Published: March 2024

Zusammenfassung
Hintergrund und Zielsetzung
Vergleichsportale können helfen, einen geeigneten medizinischen Leistungserbringer, wie z.B. eine Hebamme, zu finden. Das Ziel dieser Arbeit ist, solche Portale in Deutschland zu analysieren und ihren Nutzen für Schwangere zu beurteilen.

Methodik
Über die Suchmaschine Google wurden 25 deutsche Webseiten mit Hilfe der PRISMA-Systematik identifiziert, die eine Hebammensuche in Deutschland ermöglichen. Anhand einer Stichprobe aus 550 Hebammenprofilen wurden dort der Inhalt (Struktur-, Prozess- und Ergebnisqualität gemäß dem Qualitätsmodell von Avedis Donabedian) und die Funktionen der Webseiten (z.B. Filtern, Sortieren, Vergleichen) untersucht sowie der Nutzen der Vergleichsportale anhand einer Checkliste mit fünf Kategorien (z.B. Sozialkompetenz) evaluiert.

Ergebnisse
Die Webseiten konzentrieren sich in den meisten Fällen ausschließlich auf Hebammensuche (92 %) und werden durch Hebammen (60 %) oder ihre Verbände (16 %) mit Informationen versorgt. Ein Drittel (n = 8) der Webseiten gibt keine Informationsquelle an. Überwiegend sind Elemente der Strukturqualität und Möglichkeiten zum Suchen und Filtern von Informationen vorhanden. Mehrere bedeutende Informationen (z.B. Qualifikation, Ergebnisqualität) und Funktionen (z.B. Vergleichen, Bewerten) sind ungenügend vorhanden. Bei der Nutzenbewertung erreichten die Webseiten insgesamt 114 von 400 möglichen Punkten, was einem Abdeckungsgrad von weniger als 30% entspricht.

Diskussion und Fazit
Insgesamt konnte festgestellt werden, dass Vergleichsportale in der aktuellen Form für Schwangere bei der Suche nach einer geeigneten Hebamme nicht hilfreich sind und nicht das Potenzial haben, die Versorgung zu verbessern. Für eine adäquate Qualitätsberichterstattung auf Vergleichsportalen, müssen Informationen aus unabhängigen Quellen konsequent dargelegt werden. Neben strukturellen Informationen müssen auch „harte Fakten“ veröffentlicht werden und Bewertungen durch Patientinnen sollten möglich sein. Darüber hinaus sollten für eine bessere Handhabung der Informationen weitere Komplexität reduzierende Funktionen eingebaut werden.
Effect of Corrective Exercise on Static Balance, Food Consumption, and Body Composition in the Early Period After Bariatric Surgery
Authors: Cetin Dilara , Kucuk Yetgin Meral , Turkcapar Ahmet Gokhan , Koksalan Burke , Durmaz Sena 
Published: March 2024

Abstract
Purpose
To determine the impact of corrective exercise program applied during the period of rapid weight loss following bariatric surgery on static balance, dietary intake, and body composition.

Materials and Methods
Participants who had undergone Sleeve Gastrectomy (SG) surgery were divided into as Corrective Exercise Group (CEG), and Control Group (CG). CEG underwent a 12-week supervised corrective exercise program. Body composition and static balance of all participants were assessed before and after the study. Their physical activity levels and dietary intake were also evaluated.

Results
Following of the corrective exercise program, both groups exhibited significant reductions in body weight, BMI, fat mass, fat percentage, muscle mass, waist circumference-to-height ratio, and visceral adiposity values (p < 0.05). Additionally, the CEG showed increase in lean body mass percentage (p < 0.001). In measurements related to static balance, values for eyes-closed perimeter (p = 0.015), eyes-closed (p = 0.006), eyes-open (p = 0.028) ellipses area, average F-B speed, and eyes-open center of pressure in the X-axis (C.O.P.X.) sway distance significantly decreased in both groups (p = 0.025). However, the difference in eyes-open C.O.P.X. sway distance was found to be higher in the CG (mean difference = 8.67; p = 0.034). Postoperatively, there were significant decreases in energy, protein, fat, CHO (carbohydrate), CHO percentage, fiber, and iron values, while protein percentage (p < 0.001), vitamin D (p = 0.003), and B12 (p < 0.001) values increased.

Conclusion
It has been observed that the corrective exercise program implemented in the early postoperative period following SG surgery had a positive impact on eyes-open static balance.

Graphical Abstract
α-Tocopherol mediates alleviation of salt stress effects in Glycine max through up-regulation of the antioxidant defense system and secondary metabolites
Authors: Taie Hanan A. A. , Rady Mostafa M. 
Published: March 2024

Abstractα-Tocopherol (αT) has been reported to overcome the adverse effects of many environmental stresses, including salinity. A pot experiment was performed to investigate the response of salt-stressed soybean plants to the foliar application using 50, 100, or 200 mg αT L–1. The stress was applied by irrigation with three different dilutions of seawater [e.g., EC = 0.23 (tap water as a control), 3.13, or 6.25 dS m–1]. The gradual increase in salinity level gradually increased net carbon dioxide (CO2) assimilation, relative growth rate, antioxidant capacity, secondary metabolites (total phenolic compounds, flavonoids, and tannins), enzymatic activities, and DNA fragmentation due to the gradual increase in lipid peroxidation as a result of an increase in hydrogen peroxide (H2O2). On the contrary, yield components (number and weight of seeds plant–1) and photosynthetic pigment (total chlorophyll and carotenoids) contents gradually decreased with increasing salinity level. However, leaf treatment with αT, especially at 200 mg αT L‒1, preserved the highest antioxidant activities (antioxidant capacity, secondary metabolites, and enzymes), which were associated with the preservation of soybean yield and leaf pigments. These positive results occurred due to the reduction in lipid peroxidation as a result of a significant decrease in the level of H2O2. Therefore, our results recommend the use of 200 mg αT L–1 as a commercial formula for soybeans grown under saline irrigation of no more than 6.25 dS m–1.
Potential use of sodium glucose co-transporter 2 inhibitors during acute illness: a systematic review based on COVID-19
Authors: Tisch Carmen , Xourgia Eleni , Exadaktylos Aristomenis , Ziaka Mairi 
Published: March 2024

Abstract
Objective
SGLT-2i are increasingly recognized for their benefits in patients with cardiometabolic risk factors. Additionally, emerging evidence suggests potential applications in acute illnesses, including COVID-19. This systematic review aims to evaluate the effects of SGLT-2i in patients facing acute illness, particularly focusing on SARS-CoV-2 infection.

Methods
Following PRISMA guidelines, a systematic search of PubMed, Scopus, medRxiv, Research Square, and Google Scholar identified 22 studies meeting inclusion criteria, including randomized controlled trials and observational studies. Data extraction and quality assessment were conducted independently.

Results
Out of the 22 studies included in the review, six reported reduced mortality in DM-2 patients taking SGLT-2i, while two found a decreased risk of hospitalization. Moreover, one study demonstrated a lower in-hospital mortality rate in DM-2 patients under combined therapy of metformin plus SGLT-2i. However, three studies showed a neutral effect on the risk of hospitalization. No increased risk of developing COVID-19 was associated with SGLT-2i use in DM-2 patients. Prior use of SGLT-2i was not associated with ICU admission and need for MV. The risk of acute kidney injury showed variability, with inconsistent evidence regarding diabetic ketoacidosis.

Conclusion
Our systematic review reveals mixed findings on the efficacy of SGLT-2i use in COVID-19 patients with cardiometabolic risk factors. While some studies suggest potential benefits in reducing mortality and hospitalizations, others report inconclusive results. Further research is needed to clarify optimal usage and mitigate associated risks, emphasizing caution in clinical interpretation.
Ecosymbiotic Complementarity, an Old Theory Applicable in Today’s Ethnobiological Studies
Authors: Lotero-Velásquez Elisa , Martínez-Ballesté Andrea , Casas Alejandro , Vega Peña Ernesto Vicente 
Published: March 2024

AbstractEthnobiology analyzes the interactions between people and their surrounding environments from various perspectives. Some studies have been criticized by social scientists, who argue that ethnobiologists have insufficiently considered the conflicts between the dominant economic and political model and rural communities’ lives, which are often idealized. However, several ethnobiological studies have increasingly considered these aspects, and important initiatives in this direction have emerged from interactions with other research fields and frameworks, such as sustainability science, political ecology, agroecology, and social-ecological systems. To address criticism on what has been considered ethnobiological utopianism, it is valuable to theorize, develop methodological tools, and construct explanatory models. From such perspective, this work aims to recover an old theory called ecosymbiotic complementarity, which we propose can strengthen analytical approaches in the social-ecological systems framework. We recover the original proposal of the ecosymbiotic complementarity theory, emphasizing the relationships between rural communities and economic and political variables. We consider that the ecosymbiotic complementarity theory can contribute to the contextualization of rural societies analyzed in ethnobiological research.
Nutrition fragility in isolation: Food insecurity in Small Island Developing States
Authors: Atzori Delia , Sonneveld Ben G. J. S. , Alfarra A. , Merbis Max D. 
Published: March 2024

AbstractHigh reliance on food imports, unbalanced diets, limited cultivable land, scarce fresh water resources and remoteness are typical food security constraints for Small Island Developing States (SIDS). Calls for evidence-based food policy interventions are, therefore, justified. Yet, SIDS studies on food security are often outdated, focus on one country and use exclusive data and dedicated methodologies that cannot be applied elsewhere. This study standardized its methodology to assess availability of food groups and micronutrients at a SIDS-wide level. We use the latest release from FAO’s harmonized Food Balance Sheets and improve actual intake by correcting for food waste and lower micronutrient thresholds for under-fives. We make results interpretable with geo-visualization techniques and infographics that map food group and micronutrient availability per country against required needs. A great share of countries (94%) fails to meet food group requirements; 43% does not meet the requirement of five or more of the eight food groups. None of the SIDS meet the required doses for micronutrients and only 14% meets requirements of 13 or 14 of the 15 micronutrients, yet, 31% of the SIDS misses 6 to 8 micronutrients. Overweight prevalence is closely correlated to food group availability while stunting can be largely explained by income level. The findings prioritize policy actions by identifying absence of dietary diversity. The approach is adequate and cost-efficient based on existing databases that are regularly updated. Timeliness and country coverage of SIDS in some international databases need serious improvement.
LncRNA XIST promotes bladder cancer progression by modulating miR-129-5p/TNFSF10 axis
Authors: Kong Yu-Lin , Wang Hui-Dan , Gao Meng , Rong Sheng-Zhong , Li Xiao-Xia 
Published: March 2024

Abstract
Background
The differential expression, biological function, and ceRNA regulatory mechanism of lncRNA XIST in bladder cancer (BC) were investigated, and its clinical values for the early diagnosis of bladder cancer patients were elucidated.

Methods
qRT-PCR was employed to detect the expression patterns of lncRNA XIST, miR-129-5p and TNFSF10. The biological functions were measured by CCK8 assay, wound healing assay and transwell assay. Bioinformatics analysis and Dual-Luciferase reporter assay were employed to evaluate the interactions between the lncRNA XIST, miR-129-5p and TNFSF10.

Results
LncRNA XIST and TNFSF10 were highly expressed and miR-129-5p was low expressed (P < 0.05) in bladder cancer cell line. The depletion of lncRNA XIST inhibited BC proliferation, migration and invasion. Mechanistically, lncRNA XIST could sponge miR-129-5p to regulate TNFSF10 expression in bladder cancer. Furthermore, compared with adjacent tissues, lncRNA XIST and miR-129-5p were lowly expressed (P < 0.01) in bladder cancer tissues, and TNFSF10 was highly expressed (P < 0.001). miR-129-5p and TNFSF10 were associated with the risk of bladder cancer (P < 0.05); the difference in AUC values for the diagnosis of bladder cancer by lncRNA XIST (AUC = 0.739), miR-129-5p (AUC = 0.850) and TNFSF10 (AUC = 0.753) was statistically significant (P < 0.01), and the three genes combined AUC was 0.900, 95%CI was 0.842–0.958 with a sensitivity of 83.3% and specificity of 86.7%.

Conclusion
XIST, an elevated lncRNA in bladder cancer, inhibition of which could suppress the progression of BC. LncRNA XIST and miR-129-5p could form ceRNA to regulate the expression of TNFSF10.
Identification of gene variation feature for targeted therapy of non-small cell lung cancer through combined method of DNA and RNA sequencing
Authors: Pang Wenguang , Gong Longlong , Shi Wangpan , Zheng Hongbo , Ye Min , Chen Jiarong , Li Ronggang , Zhang Xin , Ren Dong , Wang Zheng 
Published: March 2024

AbstractNext generation sequencing (NGS) is typically used to reveal tumor gene variation feature for targeted therapy of various types of human cancers, including non-small cell lung cancer (NSCLC). Here, we report the role and potential applicable value of combining DNA and RNA sequencing in gene variation detection in NSCLC. 386 NSCLC patients with stage II-IV were enrolled and detected using NGS sequencing of DNA and RNA panels that covered all well-documented target driver genes from the Chinese Society of Clinical Oncology (CSCO). The rate of epidermal growth factor receptor (EGFR) single nucleotide variation (SNV)/indel, mesenchymal-epithelial transition factor (MET) copy number variation (CNV) and anaplastic lymphoma kinase (ALK) fusion were 52.1%, 4.1% and 6.0% in the NSCLC cohort. The landscapes of SNV/indel, CNV and gene fusion in the cohort were depicted as well. Meanwhile, we assessed detection efficacy of DNA and RNA sequencing in gene fusion. Detected number and types of gene fusion using the RNA sequencing were better than those using the DNA sequencing. Gene fusion with intergenic region was only detected by DNA sequencing and MET exon 14 skipping (METΔex14) was more easily identified by RNA sequencing. Finally, we investigated clinical correlations of SNV/indel/CNV/fusion with clinicopathologic features in the NSCLC cohort. Taken together, RNA sequencing significantly complements deficiency of DNA sequencing for gene fusion, which cooperatively presents comprehensive and reliable gene variation features and facilitate the identification of potential drug targets for NSCLC patients.
Integrating Shared Decision-Making into Undergraduate Oncology Education: A Pedagogical Framework
Authors: Lawson McLean Aaron , Lawson McLean Anna C. 
Published: March 2024

AbstractThe integration of shared decision-making (SDM) into undergraduate oncology education represents a critical evolution in medical pedagogy, reflecting the growing complexity and patient-centric focus of contemporary healthcare. This paper introduces a comprehensive pedagogical framework designed to embed SDM within the undergraduate medical curriculum, particularly in oncology, where the multiplicity of treatment options and their profound impact on patient life underscore the necessity of this approach. Grounded in a systematic literature review and aligned with established educational theories, this framework proposes twelve strategic approaches to cultivate future physicians proficient in both clinical acumen and patient-collaborative decision-making. The framework emphasizes real-world clinical experience, role-playing, case studies, and decision aids to deepen students’ understanding of SDM. It advocates for the development of communication skills, ethical deliberation, and cultural competence, recognizing the multifaceted nature of patient care. The inclusion of patient narratives and evidence-based decision-making further enriches the curriculum, offering a holistic view of patient care. Additionally, the integration of digital tools within the SDM process acknowledges the evolving technological landscape in healthcare. The paper also addresses challenges in implementing this framework, such as curricular constraints and the need for educator training. It underscores the importance of continual evaluation and adaptation of these strategies to the dynamic field of medical education and practice. Overall, this comprehensive approach aims not only to enhance the quality of oncological care but also to prepare medical students for the complexities of modern medicine, where patient involvement in decision-making is both a necessity and an expectation.
Impact of high-pressure processing on the bioactive compounds of milk - A comprehensive review
Authors: Siddiqui Shahida Anusha , Khan Sipper , Bahmid Nur Alim , Nagdalian Andrey Ashotovich , Jafari Seid Mahdi , Castro-Muñoz Roberto 
Published: March 2024

AbstractHigh-pressure processing (HPP) is a promising alternative to thermal pasteurization. Recent studies highlighted the effectivity of HPP (400–600 MPa and exposure times of 1–5 min) in reducing pathogenic microflora for up to 5 logs. Analysis of modern scientific sources has shown that pressure affects the main components of milk including fat globules, lactose, casein micelles. The behavior of whey proteins under HPP is very important for milk and dairy products. HPP can cause significant changes in the quaternary (> 150 MPa) and tertiary (> 200 MPa) protein structures. At pressures > 400 MPa, they dissolve in the following order: αs2-casein, αs1-casein, k-casein, and β-casein. A similar trend is observed in the processing of whey proteins. HPP can affect the rate of milk fat adhering as cream with increased results at 100–250 MPa with time dependency while decreasing up to 70% at 400–600 MPa. Some studies indicated the lactose influencing casein on HP, with 10% lactose addition in case in suspension before exposing it to 400 MPa for 40 min prevents the formation of large casein micelles. Number of researches has shown that moderate pressures (up to 400 MPa) and mild heating can activate or stabilize milk enzymes. Pressures of 350–400 MPa for 100 min can boost the activity of milk enzymes by up to 140%. This comprehensive and critical review will benefit scientific researchers and industrial experts in the field of HPP treatment of milk and its effect on milk components.
Graphical abstract
Analyzing and identifying predictable time range for stress prediction based on chaos theory and deep learning
Authors: Li Ningyun , Zhang Huijun , Feng Ling , Ding Yang , Li Haichuan 
Published: March 2024

Abstract
Propose
Stress is a common problem globally. Prediction of stress in advance could help people take effective measures to manage stress before bad consequences occur. Considering the chaotic features of human psychological states, in this study, we integrate deep learning and chaos theory to address the stress prediction problem.

Methods
Based on chaos theory, we embed one’s seemingly disordered stress sequence into a high dimensional phase space so as to reveal the underlying dynamics and patterns of the stress system, and meanwhile are able to identify the stress predictable time range. We then conduct deep learning with a two-layer (dimension and temporal) attention mechanism to simulate the nonlinear state of the embedded stress sequence for stress prediction.

Results
We validate the effectiveness of the proposed method on the public available Tesserae dataset. The experimental results show that the proposed method outperforms the pure deep learning method and Chaos method in both 2-label and 3-label stress prediction.

Conclusion
Integrating deep learning and chaos theory for stress prediction is effective, and can improve the prediction accuracy over 2% and 8% more than those of the deep learning and the Chaos method respectively. Implications and further possible improvements are also discussed at the end of the paper.
Reclaiming Political Rights During a Rule of Law Crisis: The Role of the UN Human Rights Committee
Authors: Almqvist Jessica 
Published: March 2024

AbstractHow should democratic states approach and respond to secessionist movements using tactics contrary to the constitution to achieve their goals? What is the role of international human rights mechanisms in these processes? This article sheds light on these questions by examining how the UN Human Rights Committee approached and assessed two complaints that came before it in the wake of the Catalan Declaration of Independence in 2017. The aim is to discuss the Committee’s examination of the merits in the two cases and the procedural hurdles faced. Specifically, it will analyse the effects of examining the merits in hindsight and the extent to which this perspective may have influenced its views. It will further reflect on the potential costs of acting with procedural flexibility towards the two complaints which, while driven by a sense of urgency, did not meet the threshold for irreparable harm. It is concluded that, while a protective stance towards petitioners is the bedrock of its mandate related to individual complaints, acting with such degree of flexibility risks undermining its procedural effectiveness and the integrity of its individual complaint procedure. It also made it come too close to act as a fourth instance in relation to facts that had already been examined by domestic courts by the time of its assessment. At the same time, it did not challenge Spain’s rule of law approach as such.
Teilhabe nach dem Renteneintritt
Authors: Hoffmann Madlain 
Published: March 2024

ZusammenfassungErwerbstätigkeit und die Teilnahme an non-formalen Bildungsaktivitäten werden als bedeutende nicht-monetäre Teilhabemöglichkeiten im Alter diskutiert. Nach dem Renteneintritt ist die Ausübung einer Erwerbstätigkeit allerdings eingeschränkt. Der Wunsch, auch in der Rentenphase erwerbstätig zu sein, kann daher nicht immer realisiert werden. Folglich müssen alternative Teilhabemöglichkeiten in Betracht gezogen werden. Bislang gibt es keine Studien, in denen untersucht wird, ob Rentnerinnen und Rentner, die ohne monetäre Motive erwerbstätig sein wollen, die Teilnahme an non-formalen Bildungsaktivitäten als Möglichkeit der Teilhabe realisieren. Konkret wird in der vorliegenden Studie untersucht, ob sich unmittelbar nach dem Renteneintritt die Teilnahme an non-formalen Bildungsaktivitäten zwischen Personen, die ohne monetäre Motive erwerbstätig sein wollen, und Personen, die keinen Erwerbswunsch haben, und Personen, die aus monetären Motiven erwerbstätig sein wollen, unterscheidet. Mit Daten des Nationalen Bildungspanels (NEPS) und logistischen Regressionsanalysen zeigt sich, dass Personen, die ohne monetäre Motive erwerbstätig sein wollen, eine höhere Wahrscheinlichkeit haben, an einer non-formalen Bildungsaktivität teilzunehmen, als Personen, die einen Erwerbswunsch mit monetären Motiven haben, und als Personen, die nicht den Wunsch haben, erwerbstätig zu sein. Die Unterschiede bleiben auch unter Berücksichtigung des Einkommens und weiterer Merkmale bestehen. Die Ergebnisse tragen zur bisherigen Forschung zu Aktivitäten im Alter bei und werden vor dem Hintergrund des aktiven Alterns und nicht-monetärer Motive diskutiert. Weitere Forschung muss klären, ob non-formale Bildungsaktivitäten unerfüllte Erwerbswünsche in der Rentenphase kompensieren oder langfristig dazu beitragen, eine Erwerbstätigkeit realisieren zu können.