bluuebunny/crossref_metadata_2025_split huggingface dataset:
A rare case of impacted mandibular premolar associated to dentigerous cyst and periodontal lesion clinical management and histological analysis
Authors: Gianfreda Francesco , Nucci Ludovica , Bollero Patrizio , Danieli Andrea , Palermo Andrea , Salvadori Paolo , Gargari Marco , Martelli Mirko 
Published: February 2025

Background: Dental cysts, particularly dentigerous cysts (DCs), are a common pathological condition affecting the jawbone. The literature categorizes DCs based on histology and associates them with impacted teeth, often leading to complications.
However, the occurrence of DCs in the elderly and their association with mandibular premolars is not well-documented, presenting a knowledge gap in dental pathology and management.
Objective: This case report aims to present a rare clinical case of an impacted mandibular premolar associated with a dentigerous cyst and a periodontal lesion, detailing the clinical management, radiographic diagnosis, histopathologic analysis, and surgical intervention.
Case presentation: A 65-year-old male patient presented with pain and mobility in tooth 36. Clinical examination, radiographic imaging, and histological analysis were conducted to diagnose and plan the treatment—the treatment involved enucleation of the DC and extraction of the impacted tooth. Histological examination was performed using hematoxylin and eosin staining to determine the nature of the cyst.
Results: The patient’s postoperative recovery was uneventful, with complete remineralization of the site after one year. Histological findings indicated a significant inflammatory infiltrate, predominantly lymphocytes, suggesting a periodontal cyst.
The impacted mandibular premolar association with a DC in an elderly patient is rare, with the literature reporting a higher frequency of such cysts in younger demographics.
Conclusions: The case report contributes to the existing literature by highlighting the successful management of a rare case of an impacted mandibular premolar with a dentigerous cyst and periodontal lesion. It emphasizes the importance of accurate diagnosis and individualized treatment planning in managing complex dental cyst cases. It suggests a conservative approach to prevent surgical risks, especially near critical anatomical structures.
The use of ozone therapy for the treatment and post-surgical management of patients treated with bilateral extraction of the included third mandibular molars
Authors: Memè Lucia , Pizzolante Tommaso , Saggiomo Anna Pia , Plaku Dervish , Inchingolo Alessio Danilo , Inchingolo Francesco , Rastelli Sofia 
Published: February 2025

The use of ozone in medicine and dentistry is well-supported in the scientific literature, particularly for its antibacterial, antiviral, anti-inflammatory, and anti-edema effects. These benefits are achieved through reductions in pro-inflammatory substances, stimulation of neoangiogenesis, and enhanced production of antioxidant enzymes. Additionally, ozone is pain-relieving by inactivating algogenic mediators and inducing endorphin release. Although ozone application devices are standard in conventional medicine, they are less so in dentistry and often have reduced performance. This study aims to evaluate the effectiveness of a specific ozone therapy device in managing postoperative pain and promoting healing in patients undergoing impacted third-molar extractions. Materials and methods: Patients scheduled for the extraction of impacted third molars were enrolled in a randomized split-mouth study to receive either ozone therapy or conventional antibiotic treatment. The Visual Analog Scale (VAS) assessed pain intensity and healing progress. Results: Patients treated with ozone therapy reported significantly lower pain levels and demonstrated qualitatively improved healing compared to the control group, with statistical significance. Conclusions: The study supports the use of ozone therapy in routine dental surgical practice, highlighting its favorable cost/benefit profile. Ozone therapy can be beneficial for impacted third-molar surgeries and broader applications in oral surgery.
Keywords: Ozone therapy in dentistry, OZONE DTA equipment, Third molar
extraction and soft tissue healing.
Anatomically guided full arch implant-prosthetic rehabilitations
Authors: Rastelli Sofia , Caporro Giulia , Severino Marco , Bernardi Sara , Botticelli Gianluca , Gasparri Alberto , Pizzolante Tommaso 
Published: February 2025

Aim: The loss of dental elements causes anatomical, functional, aesthetic, and psychological changes that reduce the patient’s quality of life and comfort. This study aims to show how implant-prosthetic restorations with full-arch immediate loading can be appropriately performed by an anatomically guided method.
Materials and methods: Two case reports of two male patients aged 69 and 60 years old who needed an implant-prosthetic full arch rehabilitation were documented to describe the surgical treatment.
Discussion: Human anatomy is the basis of any surgical treatment, so in oral surgery, the operator must have a detailed knowledge of the loco-regional anatomy of the head-neck district. For this reason, it is essential to know the topographical limits of the noble structures typically found in daily clinical practice to perform a precise surgical act under safe conditions. The validity of a complete dental arch rehabilitation method is emphasized in literature by inserting two axial implants positioned orthogonally to the occlusal plane in the anterior region and two distal implants inclined with a maximum of 30° distally in the posterior region. The literature reports of inclined implants have been proposed as an alternative to traditional protocols in rehabilitating edentulous jaws. All this can be achieved by carefully studying the clinical case at the beginning of the clinical and radiographic examination. In addition, knowledge of the anatomical reference points must be taken as a reference to obtain a method that is reproducible and adaptable to more clinical cases depending on bone mineralization.
Conclusion: Although it may seem excessively invasive, this method allows us to obtain optimal and reproducible results. It allows us to exploit not only the biomechanical advantages obtained by the structure of the prosthetic polygon but above all, those biological ones based on knowledge of the physiology of bone remodeling.
Generation of a Multi-wing Hyperchaotic System with a Line Equilibrium and its Control
Authors: Mechekef Manal , Meddour Lotfi , Houmor Tarek 
Published: February 2025

Abstract
This paper presents the development of a new hyperchaotic system, created by the extension of the established Lu system to the four-dimension. The complex dynamics of this new system are explored through both theoretical analysis and numerical simulations. The study focuses on the systems dynamic behavior, equilibrium points, Lyapunov exponents and Poincare sections, as well as bifurcation diagrams and coexisting attractors to thoroughly characterize its properties. Moreover, two main methods were investigated to control the hyperchaos, linear feedback control and adaptive control. These approaches aim to stabilize the hyperchaotic system at unstable equilibrium points, even when system parameters are either known or unknown. Numerical simulations are performed to illustrate the effectiveness of the proposed controllers.
A Portable Aspiration-Assisted Device for End-Cut Prostate Biopsy of Large Tissue Sample
Authors: Ungurait Dane , Araya Roy , Brisbane Wayne , Lampotang Samsun , Lawrence Elisabeth , Yamaguchi Hitomi 
Published: February 2025

Abstract
Needle biopsy is a common procedure used to diagnose various types of cancer, particularly prostate cancer. Current needle biopsy devices used in this procedure feature End-Cut and Side-Cut needles. They also typically have a loud and sudden spring-loaded firing mechanism with inaccurate needle positioning that can cause additional harm to the patient. A novel aspiration-assisted biopsy device has been developed by researchers at the University of Florida that uses a coaxial End-Cut needle attached to a syringe. The device utilizes vacuum pressure to retain tissue during the biopsy procedure and does not have a spring-loaded firing mechanism. This paper describes the design and development of the device and characterizes its performance by testing it on animal tissue ex-vivo alongside two other commercial biopsy devices currently used in clinical settings. Tests performed on bovine cardiac tissue ex-vivo indicated that the developed device performs comparably to the two commercial biopsy devices.
Seneca Valley virus 3C protease cleaves HDAC4 to antagonize type I interferon signaling
Authors: Li Zijian , Yang Jingjing , Ma Ruiyi , Xie Shijie , Wang Dan , Quan Rong , Wen Xuexia , Liu Jue , Song Jiangwei 
Published: February 2025

ABSTRACT

Seneca Valley virus (SVV) is a newly identified pathogen that poses a notable threat to the global pig industry. SVV has evolved multiple strategies to evade host antiviral innate immune responses. However, the underlying molecular mechanisms have not yet been fully elucidated. Histone deacetylases (HDACs) have been shown to function as host antiviral innate immune factors. In this study, we examined the mechanisms underlying SVV evasion of host innate immunity and found that SVV infection induced degradation and cleavage of HDAC4. Ectopic expression of HDAC4 suppressed SVV replication, whereas siRNA-mediated knockdown of HDAC4 enhanced SVV replication. Further studies showed that the viral 3C protease (3C
pro
) degraded HDAC4 in a protease activity- and caspase pathway-dependent manner. In addition, 3C
pro
cleaved HDAC4 at Q599, which blocked its ability to limit viral replication. We also found that HDAC4 interacted with the SVV viral RNA-dependent RNA polymerase 3D and induced its proteasomal degradation. The cleaved HDAC4 products did not block SVV replication or induce 3D degradation and did not induce type I interferon (IFN) activation and expression of IFN-stimulated genes (ISGs). Collectively, these findings identified HDAC4 as an antiviral factor with effects against SVV infection and provided mechanistic insights into how SVV 3C
pro
antagonizes its function, which has implications for viral evasion of innate immunity.

IMPORTANCE
Seneca Valley virus (SVV) is an emerging pathogen that causes vesicular disease in pigs and poses a threat to the pork industry. Histone deacetylases (HDACs) are important in the regulation of innate immunity. However, little is known about their roles in SVV infection. Our results revealed HDAC4 as an anti-SVV infection factor that targets the viral RNA-dependent RNA polymerase, 3D, for degradation. The SVV proteinase 3Cpro targets HDAC4 for degradation and cleavage, and cleavage of HDAC4 abrogated its antiviral effect. HDAC4 promotes type I interferon (IFN) signaling, and SVV 3Cpro-mediated cleavage of HDAC4 antagonized induction of type I IFN and interferon-stimulated genes (ISGs). Our findings reveal a novel molecular mechanism by which SVV 3Cpro counteracts type I IFN signaling by targeting HDAC4.
Community participation in social innovations in health: a qualitative study of women’s engagement in a local tuberculosis clinic in the Philippines
Authors: Tiangco Pauline Marie Padilla , Mier Abigail Ruth , Mier-Alpaño Jana Deborah , Muego Paul , Tongson Excelsa , del Pilar-Labarda Meredith 
Published: February 2025

BackgroundWe explore the perspectives and experiences of the Kalinga Leaders (K! Leaders), who are community volunteers of the social innovation, Kalinga Health. It is a 360° facility providing quality, affordable and comprehensive TB care in two urban cities in the Philippines. It acts as an intermediary agency between the public and private sector partners, ensuring continuity of care for patients. We explored how gender and other gender intersecting inequities and inequalities impact health conditions. Specifically, we explored how community engagement helps improve access to and uptake of health services.MethodsA grounded theory approach was used to generate data from the perspectives of the community members and K! Leaders, which were explored through site visits, key informant interviews and a focus group discussion. Field notes and recording transcripts were used for thematic analysis to identify key patterns.ResultsDespite intersecting social factors that hinder their participation, K! Leaders remain motivated to become an integral part of the tuberculosis referral system in two urban cities in the Philippines, helping improve access to and uptake of health services in the communities they serve.ConclusionsThe K! leaders’ desire to help their communities and at the same time, empower themselves, motivates them to do a balancing act, which is facilitated by the culture of Kalinga Health, enabling them to thrive in an environment that champions gender diversity and equality.
Water, sanitation and social innovations in health: a qualitative exploration of gender and intersecting social stratifiers in a rural ram-pump project in the Philippines
Authors: Mier Abigail Ruth , Tiangco Pauline Marie Padilla , Mier-Alpaño Jana Deborah , Tongson Excelsa , Muego Paul Edward , del Pilar-Labarda Meredith 
Published: February 2025

BackgroundSocial innovation plays a critical role in addressing fundamental health determinants, such as access to safe water. Observational studies highlight how clean water disproportionately affects women and girls, resulting in persistent health problems influenced by gender norms around water and sanitation. Furthermore, gender intersects with other social stratifiers—such as socioeconomic status and geographic location—exacerbating this disadvantage. This study explores how gender and social stratifiers intersect in the context of a social innovation in the Philippines, a hydraulic ram pump model, which brings water to remote upland communities. Combining community-driven approaches with technical innovation, this innovation empowers communities, improves health outcomes and fosters resilience.MethodsQualitative research methods were used, including in-depth interviews and focus group discussions. Data were analysed using a coding framework and MaxQDA software to identify key themes related to water and sanitation, gender norms and community participation.ResultsThe findings highlight how gender norms intersect with socioeconomic factors and geographical location to influence health outcomes. Gender roles influence participation and underscore how context-specific and community-driven approaches address health disparities, emphasising the role of social innovations in equitable access to water.ConclusionGender and social stratifiers intersect to shape individuals' experiences, creating disparities in health needs and access to resources like water. In social innovations, it is crucial to examine gender norms at the community level and understand the sociocultural realities people face. Social innovation research must evolve to consider these complexities, as gendered relations and intersecting social stratifiers directly influence health outcomes and access to resources.
Contribution towards gender transformative responses in community health: an exploratory rapid appraisal to initiate intersectional gender analysis of Philippine social innovations in health
Authors: Mier-Alpano Jana Deborah , Mier Abigail Ruth , Tiangco Pauline Marie Padilla , Muego Paul , Labarda Meredith , Juban Noel , Kharel Chandani , Otmani del Barrio Mariam 
Published: February 2025

IntroductionUnderstanding gender norms, roles and relations within communities is critical for effective health interventions. This preliminary study aimed to explore how gender and other intersecting social factors interact with social innovations in health in the Philippines.MethodsA rapid appraisal tool, based on an initial template provided by the Special Programme for Training and Research in Tropical Diseases, was revised following a literature review and user feedback. Social innovation cases were chosen from the database of the Social Innovation in Health Initiative Philippines Hub using specific inclusion criteria. Two independent reviewers used the checklist on these cases, leading to entry points for further intersectional gender research.ResultsThe revised appraisal tool includes gendered mapping of stakeholders, a comprehensive checklist for gender appraisal across the stages of innovation and a self-check for researchers. Eight social innovations were selected and appraised, revealing research entry points including disaggregating data by sex, gender and other social identities; exploring gendered roles, norms and distribution of responsibilities within communities and innovations; and assessing the impact of innovations on men, women and people with non-binary identities, considering their intersection with other social identities.ConclusionThis process illustrates the use of a ‘top-down’ approach (using existing social innovation and gender frameworks) and an inductive ‘bottom-up’ approach (using emerging insights from the appraisal of specific innovation cases), in creating an adaptive strategy towards gender-responsive research. Further work is needed to apply the appraisal tool to other types of innovations and for an in-depth study of the identified research entry points.
An analysis of controlled human infection studies registered on ClinicalTrials.gov
Authors: Toomey Danny , Adams-Phipps Jupiter , Wilkinson James , Pietro John , Littman Jake , Kamenicek Steffen , Kaufman Daniel , Osowicki Joshua , Roestenberg Meta , Saldanha Ian J , Jamrozik Euzebiusz 
Published: February 2025

Objectives
Controlled human infection studies (CHIS) involve intentional exposure of human volunteers to infectious agents. A previous systematic review found that adverse event (AE) reporting across CHIS is inconsistent, which makes data aggregation and reuse difficult. We hypothesised that data may be more easily aggregated using a clinical trial registry such as ClinicalTrals.gov, the largest publicly accessible registry of clinical trial data. The objectives of the current analysis were to (1) evaluate the use of ClinicalTrials.gov for CHIS data reporting and (2) compare CHIS clinical trial participant flow and AE reporting in ClinicalTrials.gov with the same data in corresponding published articles.

Design
ClinicalTrials.gov records that described a CHIS were included and data were accessed using the Aggregated Analysis of ClinicalTrials.gov application programming interface. These data were compared with results extracted from publications associated with included records’ NCT identifiers and compared in groups stratified by sponsor type, cohort size and risk of bias. Results were considered discrepant if the same number was reported unambiguously differently in the clinical trial record and its associated publications. The frequencies of these discrepancies were used to quantify the differences between reporting in ClinicalTrials.gov records and publications of the same results.

Results
We screened 5131 ClinicalTrials.gov records for inclusion, reviewed 410 records in full and included 344 records. The overall prevalence of any discrepancy was 40%. Compared with their respective groups, significant discrepancies were observed in publicly funded trials, trials in the third quartile of study size and trials with a high risk of bias in selection of the reported result. Five studies reported a total of five serious AEs in ClinicalTrials.gov records but not in any associated publications.

Conclusion
We identified an overall prevalence of discrepancy of 40% in CHIS, which is comparable with the prevalence observed in other types of clinical trials. In general, medium-sized, publicly funded trials tended to have more discrepancies in reporting, which may reflect the resources typically available to large, privately funded trials or the relative ease of reporting in smaller trials with fewer overall AEs. These results highlight the need to facilitate clear and consistent reporting in CHIS.

PROSPERO registration number
CRD42022330047.
Higgs mass predictions in the CP-violating high-scale NMSSM
Authors: Borschensky Christoph , Dao Thi Nhung , Gabelmann Martin , Mühlleitner Margarete , Rzehak Heidi 
Published: February 2025

Abstract
In a supersymmetric theory, large mass hierarchies can lead to large uncertainties in fixed-order calculations of the Standard Model (SM)-like Higgs mass. A reliable prediction is then obtained by performing the calculation in an effective field theory (EFT) framework, involving a matching to the full supersymmetric theory at the high scale to include contributions from the heavy particles, and a subsequent renormalisation-group running down to the low scale. We report on the prediction of the SM-like Higgs mass within the CP-violating next-to-minimal supersymmetric extension of the SM (NMSSM) in a scenario where all non-SM particles feature TeV-scale masses. The matching conditions are calculated at full one-loop order using two approaches. These are the matching of the quartic Higgs couplings as well as of the SM-like Higgs pole masses of the low- and high-scale theory. A comparison between the two methods allows us to estimate the size of terms suppressed by the heavy mass scale that are neglected in a pure EFT calculation as given by the quartic-coupling matching. Furthermore, we study the different sources of uncertainty which enter our calculation as well as the effect of CP-violating phases on the Higgs mass prediction. The matching calculation is implemented in a new version of the public program package

$$\texttt {NMSSMCALC}$$

NMSSMCALC

.
Four loop Green’s functions involving the $$n=2$$ moment of the Wilson operator
Authors: Gracey J. A. 
Published: February 2025

Abstract
We evaluate the Green’s function for the insertion of the second moment of the twist-2 flavour nonsinglet Wilson operator in a quark 2-point function in all three different single scale external momentum configurations at four loops in the

$$\overline{\text{ MS }}$$

MS

¯

scheme and the chiral limit. One configuration is where the operator is inserted at zero momentum while the other two are where a non-zero momentum flows out through the operator itself with one external quark momentum nullified. In the latter two configurations mixing of the operator with a total derivative twist-2 operator is included for renormalization group consistency. In addition we compute the correlation functions of both gauge invariant operators to four loops in the same scheme.