bluuebunny/crossref_metadata_2025_split huggingface dataset:
Management of childhood cholelithiasis: experience at a third-level pediatric surgical center
Authors: Scalise Davina , Boscarelli Alessandro , Giangreco Manuela , Codrich Daniela , Scarpa Maria-Grazia , Iaquinto Marianna , Pagliara Camilla , Olenik Damiana , Guida Edoardo , Schleef Jurgen 
Published: March 2024

Abstract
Background: Cholelithiasis is increasing in the pediatric population. While its etiology is primarily idiopathic, it is often related to underlying diseases, and a significant number of patients may be asymptomatic. There are currently no guidelines for the management of asymptomatic patients with both cholelithiasis and a predisposing condition. Therefore, this study seeks to highlight situations where prophylactic cholecystectomy may be desirable based on pre, intra, and postoperative complications, length of hospital stay, and disease recurrence.
Methods: We retrospectively reviewed the medical records of patients who underwent elective laparoscopic cholecystectomy between October 2011 and September 2022. Data, including clinical presentation at the time of diagnosis and admission, imaging, treatments, complications, and length of hospital stay, were collected.
Results: Thirty-two patients (21 females and 11 males) were included in the study. The median age was 14 years (range <1–17). Five different groups of patients were identified based on associated pathologies. Ten patients had hematologic disease (31.25%), four had cystic fibrosis (12.5%), six were overweight or obese (18.75%), two had an autoimmune disease (6.25%), and ten had no underlying disease (31.25%). Twenty-six patients were symptomatic (81.25%), and six were asymptomatic (18.75%). The idiopathic etiology group was entirely symptomatic. All patients underwent a laparoscopic cholecystectomy. There was one patient (in the idiopathic etiology group) who required conversion from laparoscopy to open surgery and a reintervention (3.13%). Hematologic and cystic fibrosis patients with asymptomatic cholelithiasis had a shorter length of hospital stay than patients with the same condition who progressed from asymptomatic to symptomatic gallstone disease.
Conclusions: Patients with cystic fibrosis and hematologic diseases who have concomitant asymptomatic cholelithiasis may benefit from early laparoscopic cholecystectomy, which could reduce the probability of surgical and postsurgical complications and shorten the length of hospital stays.
TET2 Deficiency Increases the Competitive Advantage of Hematopoietic Stem Cells through Upregulation of Thrombopoietin Receptor Signaling
Authors: Chan Steven , Yang Yitong , Cathelin Severine , Liu Alex , Subedi Amit , Maher Abdula , Hosseini Mohsen , Ayyathan Dhanoop Manikoth , Vanner Robert 
Published: March 2024

Abstract
Ten-Eleven Translocation-2 (TET2) mutations drive the expansion of mutant hematopoietic stem cells (HSCs) in clonal hematopoiesis (CH). However, the precise mechanisms by which TET2 mutations confer a competitive advantage to HSCs remain unclear. Here, through an epigenetic drug screen, we discovered that inhibition of disruptor of telomeric silencing 1-like (DOT1L), a H3K79 methyltransferase, selectively reduced the fitness of Tet2 knockout (Tet2KO) hematopoietic stem and progenitor cells (HSPCs). Mechanistically, we found that TET2 deficiency increased H3K79 dimethylation and expression of Mpl, which encodes the thrombopoietin receptor (TPO-R). Correspondingly, TET2 deficiency was associated with a higher proportion of primitive Mpl-expressing (Mpl+) cells in the HSC compartment. Importantly, inhibition of Mpl expression or the signaling downstream of TPO-R was sufficient to reduce the competitive advantage of murine and human TET2-deficient HSPCs. Our findings demonstrate a critical role for aberrant TPO-R signaling in TET2 mutation-driven CH and uncover potential therapeutic strategies against this condition.
Natural Herbal Compounds Exerting an Antidepressant Effect
through Hypothalamic-Pituitary-Adrenal Axis Regulation
Authors: Wang Nailong , Yu Binrui , Liu Jiayin , Lan Wei 
Published: March 2024

Abstract:
Depression is a common mental illness that damages the life and health of patients
and causes economic burden, and HPA (hypothalamic-pituitary-adrenal) axis dysfunction
is considered to be one of the important factors leading to depression. In this
case, it is essential to explore possible treatment methods by using natural compounds
with HPA axis regulating and antidepressant effects. However, no one has reviewed it
so far. Therefore, the purpose of this review is to systematically sort out the related natural
products that play an antidepressant role by regulating the function of the HPA axis.
Natural products are divided into flavonoids, polyphenols, terpenoids, saponins,
polysaccharides and so on according to their chemical structures, which play a variety of
biological activities such as regulating the HPA axis, anti-inflammation and neuroprotection.
These effects may provide a useful reference for the potential treatment of depression
so as to develop new antidepressants.
Plant Soup Formulations Show Cholinesterase Inhibition Potential in the
Prevention of Alzheimer’s Disease
Authors: Gajowniczek-Ałasa Dorota , Szwajgier Dominik , Baranowska-Wójcik Ewa 
Published: March 2024

Background:
As the cholinesterase theory is a prominent hypothesis underlying our
current understanding of Alzheimer's disease (AD), the goal of this study was to compose functional
vegan lunchtime soups with potential health benefits in the prevention of AD (in the context of
cholinesterase inhibition).

Materials and Methods::
The potential of 36 edible plant raw materials in terms of acetyl- and butyrylcholinesterase
inhibition was investigated using a 96-well microplate reader. The most
promising ingredients were combined to obtain 18 palatable vegetable soup recipes with 6 dominant
flavor, appearance, and aroma variants. To shortlist candidates for in-depth analysis and potential
consideration in industrial production, our team performed a sensory analysis of the soups.

Results::
The white boletus soup exhibited the highest potential for cholinesterase inhibition, further
bolstered by the inclusion of other ingredients known for their elevated capacity to inhibit
both AChE and BChE. Ingredients such as blackthorn (Prunus spinosa), garlic, and white potato
contributed significantly to this inhibitory effect (nearly 100% of AChE inhibition). Notably, intriguing
results were also observed for asparagus soup, despite the fact that the inhibitory potential
of asparagus itself is negligible compared to other raw materials. The success of the asparagus
soup lies in the meticulous selection of various ingredients, each contributing to its overall effectiveness.
It was observed that mushroom soups scored the highest in this respect, while the team
members’ response to nettle soup was the least favorable.

Conclusion:
The outcomes of our study should serve as a catalyst for further exploration of this
important research domain. Our current research focuses on deeper insights into the potential of
comprehensive meal options. Furthermore, the synergy/antagonism/non-interaction between respective
soup ingredients as well as elements of individual soups’ chemical composition is a very
interesting topic currently under our intensive scientific investigation.
Synthesis and In vitro and In silico Anti-inflammatory Activity of New
Thiazolidinedione-quinoline Derivatives
Authors: da Silva Sandra Elizabeth Barbosa , da Silva Moura José Arion , Branco Júnior Jeann Fabiann , de Moraes Gomes Paulo André Teixeira , de Paula Simão Kalebe Silva , Francisco Viana Douglas Carvalho , de Freitas Ramalho Eduardo Augusto Vasconcelos , de Melo Gomes João Victor , Pereira Michelly Cristiny , da Rocha Pitta Maira Galdino , da Rocha Pitta Ivan , da Rocha Pitta Marina Galdino 
Published: March 2024

Background:
Inflammation is a series of complex defense-related reactions. The inflammation
cascade produces various pro-inflammatory mediators. Unregulated production of these
pro-inflammatory mediators can lead to a wide range of diseases, including rheumatoid arthritis,
sepsis, and inflammatory bowel disease. In the literature, the anti-inflammatory action of quinoline
and thiazolidinedione nuclei are well established, alone, and associated with other nuclei.
The synthesis of hybrid molecules is a strategy for obtaining more efficient molecules due to the
union of pharmacophoric nuclei known to be related to pharmacological activity.

Objective:
Based on this, this work presents the synthesis of thiazolidinedione-quinoline molecular
hybrids and their involvement in the modulation of cytokines involved in the inflammatory reaction
cascade.

Methods:
After synthesis and characterization, the compounds were submitted to cell viability test
(MTT), ELISA IFN-γ and TNF-α, adipogenic differentiation, and molecular docking assay with
PPARy and COX-2 targets.

Results:
LPSF/ZKD2 and LPSF/ZKD7 showed a significant decrease in the concentration of IFN-
γ and TNF-α, with a dose-dependent behavior. LPSF/ZKD4 at a concentration of 50 μM significantly
reduced IL-6 expression. LPSF/ZKD4 demonstrates lipid accumulation with significant differences
between the untreated and negative control groups, indicating a relevant agonist action
on the PPARγ receptor. Molecular docking showed that all synthesized compounds have good
affinity with PPARγ e COX-2, with binding energy close to -10,000 Kcal/mol.

Conclusion:
These results demonstrate that the synthesis of quinoline-thiazolidinedione hybrids
may be a useful strategy for obtaining promising candidates for new anti-inflammatory agents.
Formulation and Evaluation of Aprepitant Nanosuspension by Nano Precipitation Techniques
Authors: Samal Himansu Bhusan , Samal Lipsa , Kar Annada , Das Itishree Jogamaya , Sarkar Bishal , Mondal Arijit , Dey Suddhasattya 
Published: March 2024

Objective:
The majority of new chemical substances generated by the drug development
process are poorly water-soluble or lipophilic. Formulation of a poorly water-soluble substance
is a difficult task for the pharmaceutical industry. It is widely acknowledged that using nanosuspension
in drug administration enhances the drug’s solubility, dissolution, and ultimately bioavailability.
This study aimed to examine the particle sizes of nanosuspensions made by nanoprecipitation
techniques and improve their effectiveness.

Methods:
Aprepitant’s nanosuspension has been produced by nanoprecipitation techniques. The
particle size, polydispersity index, along zeta potential of the produced nanosuspensions were measured.
The optimized nanosuspension has been investigated further for solubility, dissolution, surface
morphology, FT-IR, DSC as well as stability studies.

objective:
The majority of new chemical substances generated by the drug development process are poorly water soluble or lipophilic. Formulation of a poorly water-soluble substance is a difficult task for the pharmaceutical industry. It is widely acknowledged that using nanosuspension in drug administration enhances the drug’s solubility, dissolution, and ultimately bioavailability. This study aimed to examine the particle sizes of nanosuspensions made by nano precipitation techniques and improve its effectiveness.

Results:
The combination of tween 80 and poloxamer 188 as stabilizer resulted in the preparation
of an optimized nanosuspension (F9) with a particle size of 738 nm, polydispersity index 0.236,
zeta potential -15.1 mV and an improved solubility and dissolution profile compared to pure
drugs. Positive performance improvement was observed in the solubility and dissolution studies.
The crystallinity changed upon nanosizing, as demonstrated by the SEM, FT-IR and DSC analysis.

method:
Aprepitant’s nanosuspension has been produced by nano precipitation techniques. The particle size, polydispersity index along with zeta potential of the produced nanosuspensions were measured. The optimized nanosuspension has been investigated further for solubility, dissolution, surface morphology, FT-IR, DSC as well as stability studies.

Conclusion:
The nanoprecipitation method was effective in producing a stable Aprepitant nanosuspension
with improved solubility and dissolution rate.
Description and Preferences of Tarsier (Tarsius supriatnai) Nest Trees in Nantu Wildlife Reserve, Gorontalo
Authors: Repi Terri 
Published: March 2024

Tarsiers (Tarsius supriatnai) were part of the endemic primates in Sulawesi categorized as vulnerable in the IUCN red list. Therefore, this research aimed to describe and analyze the characteristics, preferences, and determinant factors influencing the use of nest trees by tarsiers in Nantu Wildlife Reserve, Gorontalo. This research used a direct observation method to collect data for three months, from September to November 2013, focusing on temperature, humidity, light intensity, tree height, tree diameter, nest height from the ground, and frequency of nest use. Moreovr, the Neu index was applied to determine nest preferences and multiple linear regression analysis was used to analyze the factors influencing nest tree selection. The results showed that the primates preferred eight nest trees, including Ficus altissima (w=1.58) and Ficus benjamina (w=1.50). Multiple linear regression analysis showed that the humidity (4.103±3.674%, P>0.05) and light intensity (126.362±41.149 lx, P<0.05) became dominant factors influencing the frequency of nest use. The results generally showed that vegetation species and microclimate conditions were crucial for tarsiers, indicating the importance of preserving forest areas to ensure the conservation of these primates.
World Yearbook of Education: Comparative Methodology in the Era of Big Data and Global Networks
Authors: Baniadam Ismail 
Published: March 2024

Global network platform as the most considerable context integrated by variety of modern and upgraded methodologies including digital and online methodologies along with all benefits and challenges paving the way for all scholars and educational experts to consider their studies regarding data visualization implementation for the sake of learning and teaching purposes in various ways. Examining the multiple perspectives of the present volume, it evaluates some critical technological developments that shed light on the novel assumptions and values in the era of global networks demanded at international education context.
PENGARUH MANAJEMEN PUNCAK, KUALITAS SIA DAN KEMAMPUAN TEKNIK PERSONAL TERHADAP EFEKTIVITAS SIA
Authors: Wulandari Kadek Desik Ani , Astuti Partiwi Dwi , Mita Miati Ni Luh Putu 
Published: March 2024

Penelitian ini bertujuan untuk menguji secara empiris dukungan manajemen puncak, kualitas sistem informasi akuntansi, kemampuan teknik personal terhadap efektivitas sistem informasi akuntansi. Populasi dalam penelitian adalah LPD se-Kota Denpasar dengan sampel yang digunakan yaitu sebanyak 35 LPD yang ditentukan dengan teknik sampel jenuh. Teknik analisis data yang digunakan untuk menguji dalam penelitian ini adalah regresi linier berganda. Berdasarkan hasil penelitian dapat dilihat bahwa dukungan manajemen puncak berpengaruh positif dan signfikan terhadap efektivitas sistem informasi akuntansi, kualitas sistem informasi akuntansi berpengaruh positif signifikan terhadap efektivitas sistem informasi akuntansi dan kemampuan teknik personal berpengaruh positif signifikan terhadap efektivitas sistem informasi akuntansi. Penelitian ini bermanfaat memperkuat Technology Acceptance Model (TAM) dalam penerimaan dan penggunaan suatu sistem informasi akuntansi.Saran bagi penelitian ini yaitu Bagi peneliti selanjutnya hendaknya menambahkan variabel lainnya seperti kecangihan teknologi informasi, pendidikan dan pelatihan serta kinerja individual.
Efektivitas Program Herregistrasi dalam Upaya Mewujudkan Pedagang yang Disiplin di Pasar Induk Puspa Agro
Authors: Reswari Risma Ardana , Manggalou Singgih 
Published: March 2024

Program herregistrasi merupakan kegiatan pendaftaran ulang bagi pemilik lapak di Pasar Induk Puspa Agro yang bertujuan sebagai kegiatan penertiban pedagang terkait urusan administrasi serta memberi pemahaman bagi pedagang mengenai pentingnya keamanan dan fasilitas yang didapatkan oleh pedagang. Program ini berjalan dengan bantuan mahasiswa magang sebagai perwakilan dari tim marketing PT. Puspa Agro. Penelitian ini memiliki tujuan yaitu untuk mengetahui efektivitas dari program herregistrasi dalam mewujudkan pedagang yang disiplin. Metode yang digunakan penulis dalam penelitian ini adalah penelitian deskriptif dengan pendekatan kualitatif. Penelitian ini menggunakan beberapa variabel dalam mengukur efektivitas program, yaitu sosialisasi program, tujuan program, dan pemantauan program. Menurut penelitian yang sudah dilakukan dapat diketahui bahwa efektivitas dari program herregistrasi belum terpenuhi secara sepenuhnya. Dikarenakan dalam implementasinya terdapat permasalahan seperti adanya persyaratan pembayaran yang belum dipenuhi oleh pedagang dan kurangnya kesadaran pedagang untuk melakukan herregistrasi yang mengakibatkan pedagang merasa kesulitan dalam melakukan herregistrasi. Pemantauan dan monitoring terhadap program herregistrasi ini sudah dilakukan secara maksimal secara langsung oleh Direktur PT. Puspa Agro.
Letramento(s) histórico(s): Uma proposta plural para o ensino e a aprendizagem de História
Authors: Bastos Rocha Helenice Aparecida 
Published: March 2024

O artigo aborda os termos letramento e letramento histórico, registrando que sua acepção está em construção e sujeita a disputas. Demonstra que há, ao menos duas tendências predominantes em sua compreensão e defende uma proposta pluralista de letramento histórico, em que o mesmo ocorre na relação com diferentes instâncias sociais, culturas escritas e históricas. Nessa proposta, defende o investimento em letramentos históricos sustentados em diferentes eixos e dimensões, oportunizando uma formação histórica ampla aos alunos da escola brasileira.
A estrada perdida: as transformações na Amazônia setentrional provocadas pela construção inacabada da rodovia Perimetral Norte.
Authors: Ribeiro da Costa Paulo Nilber , Martins deSouza César 
Published: March 2024

Resumo:O presente artigo busca compreender o processo de construção da Rodovia BR-210 mais conhecida como Perimetral Norte, que nunca foi concluída. A análise de jornais e de decretos evidencia que os grandes projetos da ditadura para a Amazônia, planejados sob a lógica desenvolvimentista da década de 1970, nos governos dos generais-presidentes Emílio Garrastazu Médici (1969-1974) e Ernesto Geisel (1974-1979) como a rodovia Perimetral Norte, pensavam o progresso como algo advindo de fora da região. Ao analisarmos as fontes e a historiografia, podemos perceber que a construção contribui para entendermos aspectos importantes das políticas adotadas durante os governos dos generais para a região amazônica. Palavras-chave: Integração; colonização; ditadura militar; Perimetral Norte. Abstract:This article seeks to understand the construction process of the BR-210 Highway, better known as Perimetral Norte, which was never completed. The analysis of newspapers and decrees shows that the great projects of the dictatorship for the Amazon, planned under the developmentalist logic of the 1970s, under the governments of general presidents Emílio Garrastazu Médici (1969-1974) and Ernesto Geisel (1974-1979) like the Perimetral Norte highway, they thought of progress as coming from outside the region. When analyzing the sources and the historiography, we can see that the construction contributes to understanding important aspects of the policies adopted during the governments of generals to the Amazon region.Keywords: Integration; colonization; military governments; Perimetral Norte.
‘Because they measure success differently’: building students’ understandings of how historical accounts are made - possibility and potential
Authors: Chapman Arthur 
Published: March 2024

Abstract: There are extensive traditions of international research focused on developing thinking in history, however, research tends often to focus on students’ historical thinking more than on their metahistorical thinking. Drawing on historical theory and on research into children’s thinking (Lee, 2001; AUTHOR, 2009) and on teaching intervention studies (AUTHOR, 2010, AUTHOR, et al., 2012; AUTHOR 2015), this paper argues for the importance of a metahistorical approach to historical learning in order to help young people develop sophisticated understandings of historical debates and controversies and in order to provide them with the intellectual tools that they will need to think critically about historiography in the academy and, perhaps, more broadly.Keywords: History education; Epistemology; Historiography.Resumo: Existem extensas tradições de pesquisa internacional focadas no desenvolvimento do pensamento em história, no entanto, a pesquisa tende muitas vezes a se concentrar no pensamento histórico dos estudantes mais do que em seu pensamento meta-histórico. Com base na teoria da história e na pesquisa sobre o pensamento infantil (LEE, 2001; AUTHOR, 2009) e no ensino de estudos de intervenção pedagógica (AUTHOR, 2010, AUTHOR, ET AL., 2012; AUTHOR 2015), este artigo defende a importância de uma abordagem meta-histórica da aprendizagem histórica para ajudar os jovens a desenvolver entendimentos sofisticados de debates e controvérsias históricas e, com isso, fornecer-lhes as ferramentas intelectuais de que precisarão para pensar criticamente sobre a historiografia na academia e, talvez, de forma mais ampla.Palavras-chave: Educação histórica; Epistemologia; Historiografia.
Nefario crimen
Authors: Peter de Lima Rafael 
Published: March 2024

Resumo: O presente estudo tem por objetivo descrever e analisar dinâmicas específicas das redes de tráfico ilegal de orientais negros escravizados em solo brasileiro, que atuavam em meados do século XIX. O foco da investigação se concentra em casos de indivíduos que foram retiradas do território uruguaio e conduzidas à capital imperial brasileira. O texto também se propõe a explorar vieses característicos das ações das vítimas e de seus principais defensores legais, as autoridades consulares e diplomáticas da República uruguaia no Brasil.

Palavras-chave: Escravizações ilegais. Tráfico escravo. Brasil-Uruguai.

Abstract: The present study aims to describe and analyze specific dynamics of the illegal trafficking networks of black orientals enslaved on Brazilian soil, which operated in the mid-nineteenth century. The focus of the investigation focuses on cases of individuals who were removed from Uruguayan territory and taken to the Brazilian imperial capital. The text also proposes to explore biases characteristic of the victims' actions and of their main legal defenders, the consular and diplomatic authorities of the Uruguayan Republic in Brazil.

Keywords: Illegal enslavement. Slave traffic. Brazil-Uruguay.