bluuebunny/crossref_metadata_2025_split huggingface dataset:
Semi‐flooded cooling for high torque density modular permanent magnet machines
Authors: Zhang W. , Li G. J. , Zhu Z. Q. , Ren B. , Chong Y. C. 
Published: April 2024

AbstractThe authors investigate a semi‐flooded cooling technology for modular permanent magnet machines using flux gaps (FGs) in alternate stator teeth for extra cooling channels. The investigated machine is separated into stationary and rotational components by a polyether ether ketone sleeve. Liquid is directed into the stationary component to achieve a significant temperature reduction, at the same time, avoiding the liquid leakage into the rotating component that will cause an increase in friction losses. The FGs in the modular machine increase the contact area between coolant and machine components, resulting in better cooling efficiency. Furthermore, the FGs contribute to reduced pressure loss by minimising system flow resistance. The influence of the FG width on improving machine cooling efficiency, lowering machine temperature, and reducing pressure losses is delved. Additionally, the investigation considers the impact of inlet and outlet areas to reveal the influences stemming from fluid expansions and contractions in these regions. Computational fluid dynamics (CFD) modelling is employed to simulate the cooling performances of the investigated machines. In addition, the flow network analysis has also been employed to help understand the fluid behaviour within machines. A series of tests have been carried out to validate the CFD modelling.
A comprehensive framework for predicting electric vehicle's participation in ancillary service markets
Authors: Jahromi Saeed Naghdizadegan , Abdollahi Amir , Heydarian‐Forushani Ehsan , Shafiee Mehdi 
Published: April 2024

AbstractElectric vehicles (EVs) have significant potential to offer unused capacity in ancillary service markets, providing unique opportunities for market operators to utilise these resources. EVs have a rapid response and high availability, making them a good fit for the frequency containment reserve (FCR) market. However, EV aggregators (EVAGs) must aggregate capacity blocks due to the limited capacity of individual EVs. An application of a supervised machine learning method named XGBoost is suggested to help EVAGs predict the amount of EV participation in the FCR market. The objective is to forecast yearly involvement using data from only a single week, using the game theory method SHapley Additive exPlanations (SHAP) to minimise extra data. The proposed strategy helps aggregators and uses feature engineering to select EVs with high potential to boost revenue. The proposed framework is effective in predicting EV performance in the DK‐2 market, as shown by multiple analyses.
LettuceDB: an integrated multi-omics database for cultivated lettuce
Authors: Zhou Wenhui , Yang Tao , Zeng Liucui , Chen Jing , Wang Yayu , Guo Xing , You Lijin , Liu Yiqun , Du Wensi , Yang Fan , Hua Cong , Cai Jia , van Hintum Theo , Liu Huan , Gu Ying , Wei Xiaofeng , Wei Tong 
Published: April 2024

Abstract
Crop genomics has advanced rapidly during the past decade, which generated a great abundance of omics data from multi-omics studies. How to utilize the accumulating data becomes a critical and urgent demand in crop science. As an attempt to integrate multi-omics data, we developed a database, LettuceDB (https://db.cngb.org/lettuce/), aiming to assemble multidimensional data for cultivated and wild lettuce germplasm. The database includes genome, variome, phenome, microbiome and spatial transcriptome. By integrating user-friendly bioinformatics tools, LettuceDB will serve as a one-stop platform for lettuce research and breeding in the future.
Database URL: https://db.cngb.org/lettuce/
Adapting to organizational change in a public sector high-reliability context: the role of negative affect and normative commitment to change
Authors: Pircher Verdorfer Armin , van Ginkel Gerco 
Published: April 2024

Abstract
This study aims to investigate the impact of organizational change in a public sector high-reliability context. Drawing on conservation of resources theory, our theoretical model posits that change can be stressful and cause negative affective reactions toward the change, which undermine adjustment and post-change functioning. A quantitative case study was carried out on a Dutch air force squadron undergoing a significant organizational change, including the collection of three waves of survey data from squadron members. The data underwent analysis through a process of moderated mediation. Consistently with the theoretically derived hypotheses, results show that negative affect toward the change predicted important adjustment indicators, that is, higher levels of work role overload and work errors. Furthermore, we found that the detrimental effects of negative affect were mitigated by the level of normative commitment to change, that is, the felt obligation to provide support for the change. Overall, the study’s intended contribution lies in its detailed examination of change dynamics in the specific context of public high-reliability organizations and its potential to inform theory and practice in that area.
A Superconducting Tensor Detector for Mid-Frequency Gravitational Waves: Its Multichannel Nature and Main Astrophysical Targets
Authors: Bae Yeong-Bok , Park Chan , Son Edwin J , Ahn Sang-Hyeon , Jeong Minjoong , Kang Gungwon , Kim Chunglee , Kim Dong Lak , Kim Jaewan , Kim Whansun , Lee Hyung Mok , Lee Yong-Ho , Norton Ronald S , Oh John J , Oh Sang Hoon , Paik Ho Jung 
Published: April 2024

Abstract
Mid-frequency band gravitational-wave detectors will be complementary to the existing Earth-based detectors (sensitive above 10 Hz or so) and the future space-based detectors such as the Laser Interferometer Space Antenna (LISA), which will be sensitive below around 10 mHz. A ground-based superconducting omnidirectional gravitational radiation observatory (SOGRO) has recently been proposed along with several design variations for the frequency band of 0.1–10 Hz. For two conceptual designs of SOGRO (i.e. SOGRO and advanced SOGRO [aSOGRO]), we examine their multichannel natures, sensitivities, and science cases. One of the key characteristics of the SOGRO concept is its six detection channels. The response functions of each channel are calculated for all possible gravitational wave (GW) polarizations including scalar and vector modes. Combining these response functions, we also confirm the omnidirectional nature of SOGRO. Hence, even a single SOGRO detector will be able to determine the position of a source and polarizations of GWs, if detected. Taking into account SOGRO’s sensitivity and technical requirements, two main targets are most plausible: GWs from compact binaries and stochastic backgrounds. Based on assumptions we consider in this work, detection rates for intermediate-mass binary black holes (in the mass range of hundreds up to $10^{5}\, M_\odot$) are expected to be 0.0065–8.1 yr−1. In order to detect the stochastic GW background, multiple detectors are required. Two aSOGRO detector networks may be able to put limits on the stochastic background beyond the indirect limit from cosmological observations.
The blood-testis barrier disruption is a prerequisite for toxicant-induced peritubular macrophage increases in the testis of peripubertal rats
Authors: Fang Xin , Tiwary Richa , Nguyen Vivian P , Richburg John H 
Published: April 2024

Abstract
Peritubular macrophages (PTMφ) are predominantly localized near spermatogonial stem cells in the testis. We previously revealed that exposure of peripubertal male Fischer rats to mono-(2-ethylhexyl) phthalate (MEHP) leads to increased PTMφs in the testis. The mechanisms that trigger increases in PTMφs in the testis are poorly understood. However, MEHP exposure is known to both induce spermatocyte apoptosis and to perturb the blood-testis barrier (BTB). This study aims to elucidate the association between the disruption of BTB and the increases of PTMφs in the testis by comparing the effects observed with MEHP to 2 other testicular toxicants with variable effects on the BTB and subtype of germ cell undergoing apoptosis. Methoxyacetic acid (MAA) acts directly on spermatocytes and does not affect BTB function, whereas cadmium chloride (CdCl2) induces profound injury to BTB. The results indicated that MAA exposure significantly increased spermatocyte apoptosis, whereas no significant changes in the numbers of PTMφs in the testis occurred. In contrast, CdCl2 exposure disrupted BTB function and increased the abundance of PTMφs in the testis. To further investigate whether MEHP-induced changes in BTB integrity accounted for the increase in PTMφs, a plasmid for LG3/4/5, the functional component of laminin-alpha 2, was overexpressed in the testis to stabilize BTB integrity before MEHP exposure. The results showed that LG3/4/5 overexpression substantially reduced the ability of MEHP to compromise BTB integrity and prevented the increase in PTMφ numbers after MEHP exposure. These results indicate that BTB disruption is necessary to increase PTMφs in the testis induced by toxicants.
Maintaining Community During Disruption: Lessons From the Accelerating Change in Medical Education Consortium
Authors: Elliott Victoria Stagg , Hammoud Maya M. , Richardson Judee , Santen Sally A. , Van Rite Eric , Lomis Kimberly D. 
Published: April 2024

Abstract
When the COVID-19 pandemic emerged early in 2020, the American Medical Association’s (AMA) Accelerating Change in Medical Education Consortium focused on maintaining its community of 37 medical schools and 11 graduate medical education projects along with the core substance of its work. The initial response was to cancel events and reduce the workload of consortium members, but it quickly became clear that the consortium needed additional strategies. The constituents needed resources, support, and community. The authors, along with the rest of the AMA team, learned to maximize the benefits and minimize the drawbacks of operating virtually. These insights supported the continuation, and even expansion, of the consortium’s innovations despite extremely stressful circumstances. In this Scholarly Perspective, the authors outline the actions that they and the AMA team took in 2020 and 2021 at the beginning of the pandemic and as that crisis progressed and was further intensified by the significant distress reflected in the protests after the murder of George Floyd. The goal of these actions was to maintain the consortium’s core substance, innovation, momentum, and sense of community. The authors describe lessons learned in 2020 and 2021 via a novel model developed to facilitate ongoing collaboration and respond rapidly to the needs of overwhelmed medical educators. This model is composed of 4 phases: assessing needs, mining experts, convening people, and generating products. This model for leveraging a community of practice can help educators optimize collaboration, whether educators are pursuing innovation in the training of physicians or other health care professionals and whether in times of extreme stress or stability, the model provides a pathway for maintaining community. The prepandemic way of working will not return. Virtual participation and collaboration will remain a part of work and daily life for the foreseeable future and beyond.
Variants in autophagy genes MTMR12 and FAM134A are putative modifiers of the hepatic phenotype in α1-antitrypsin deficiency
Authors: Tafaleng Edgar N. , Li Jie , Wang Yan , Hidvegi Tunda , Soto-Gutierrez Alex , Locke Adam E. , Nicholas Thomas J. , Wang Yung-Chun , Pak Stephen , Cho Michael H. , Silverman Edwin K. , Silverman Gary A. , Jin Sheng Chih , Fox Ira J. , Perlmutter David H. 
Published: April 2024

Background and Aims:
In the classical form of α1-antitrypsin deficiency, a misfolded variant α1-antitrypsin Z accumulates in the endoplasmic reticulum of liver cells and causes liver cell injury by gain-of-function proteotoxicity in a sub-group of affected homozygotes but relatively little is known about putative modifiers. Here, we carried out genomic sequencing in a uniquely affected family with an index case of liver failure and 2 homozygous siblings with minimal or no liver disease. Their sequences were compared to sequences in well-characterized cohorts of homozygotes with or without liver disease, and then candidate sequence variants were tested for changes in the kinetics of α1-antitrypsin variant Z degradation in iPS-derived hepatocyte-like cells derived from the affected siblings themselves.

Approach and Results:
Specific variants in autophagy genes MTMR12 and FAM134A could each accelerate the degradation of α1-antitrypsin variant Z in cells from the index patient, but both MTMR12 and FAM134A variants were needed to slow the degradation of α1-antitrypsin variant Z in cells from a protected sib, indicating that inheritance of both variants is needed to mediate the pathogenic effects of hepatic proteotoxicity at the cellular level. Analysis of homozygote cohorts showed that multiple patient-specific variants in proteostasis genes are likely to explain liver disease susceptibility at the population level.

Conclusions:
These results validate the concept that genetic variation in autophagy function can determine susceptibility to liver disease in α1-antitrypsin deficiency and provide evidence that polygenic mechanisms and multiple patient-specific variants are likely needed for proteotoxic pathology.
Nurse-Led Care Coordination in a Transitional Clinic for Uninsured Patients With Diabetes
Authors: Coiner Sarah , Hernandez Alison , Midyette Paula , Patel Bela , Talley Michele 
Published: April 2024

Purpose/Objectives:
The purpose of this article is to inform the reader of the practice of the registered nurse care coordinator (RNCC) within an interprofessional, nurse-led clinic serving uninsured diabetic patients in a large urban city. This clinic serves as a transitional care clinic, providing integrated diabetes management and assisting patients to establish with other primary care doctors in the community once appropriate. The clinic uses an interprofessional collaborative practice (IPCP) model with the RNCC at the center of patient onboarding, integrated responsive care, and clinic transitioning.

Primary Practice Setting:
Interprofessional, nurse-led clinic for uninsured patients with diabetes.

Findings/Conclusions:
Interprofessional models of care are strengthened using a specialized care coordinator.

Implications for Case Management Practice:
Care coordination is a key component in case management of a population with chronic disease. The RNCC, having specialized clinical expertise, is an essential member of the interdisciplinary team, contributing a wide range of resources to assist patients in achieving successful outcomes managing diabetes. Transitional care coordination, moving from unmanaged to managed diabetes care, is part of a bundled health care process fundamental to this clinic's IPCP model. In a transitional clinic setting, frequent interaction with patients through onboarding, routine check-ins, and warm handoff helps support and empower the patient to be engaged in their personal health care journey.
Continuing Insurance Coverage for Flap-Based Breast Reconstruction
Authors: Foppiani Jose A. , Kim Erin , Weidman Allan A. , Alvarez Angelica Hernandez , Escobar-Domingo Maria J. , Valentine Lauren , Lee Theodore C. , Mathes David W. , Lee Bernard T. , Lin Samuel J. 
Published: April 2024

Background
The recent proposed alterations to the Centers for Medicare and Medicaid Services regulations, although subsequently reversed on August 21, 2023, have engendered persistent concerns regarding the impact of insurance policies on breast reconstruction procedures coverage. This study aimed to identify factors that would influence women's preferences regarding autologous breast reconstruction to better understand the possible consequences of these coverage changes.

Methods
A survey of adult women in the United States was conducted via Amazon Mechanical Turk to assess patient preferences for breast reconstruction options, specifically deep inferior epigastric perforator (DIEP) and transverse rectus abdominis myocutaneous (TRAM) flap surgery. The Cochrane-Armitage test evaluated trends in flap preferences concerning incremental out-of-pocket payment increases.

Results
Of 500 total responses, 485 were completed and correctly answered a verification question to ensure adequate attention to the survey, with respondents having a median (interquartile range) age of 26 (25–39) years. When presented with the advantages and disadvantages of DIEP versus TRAM flaps, 78% of respondents preferred DIEP; however, as DIEP's out-of-pocket price incrementally rose, more respondents favored the cheaper TRAM option, with $3804 being the “indifference point” where preferences for both procedures converged (P < 0.001). Notably, respondents with a personal history of breast reconstruction showed a higher preference for DIEP, even at a $10,000 out-of-pocket cost (P = 0.04).

Conclusions
Out-of-pocket cost can significantly influence women's choices for breast reconstruction. These findings encourage a reevaluation of emergent insurance practices that could potentially increase out-of-pocket costs associated with DIEP flaps, to prevent cost from decreasing equitable patient access to most current reconstructive options.
Epidemiological Predictors of Financial Toxicity in Surgical Burn Injuries
Authors: Sana Hamaiyal , Ehsan Anam N. , Saha Shivangi , Hathi Preet , Malapati Sri Harshini , Katave Coral , Ganesh Praveen , Huang Chuan-Chin , Vengadassalapathy Srinivasan , Sabapathy S Raja , Kumar Neeraj , Chauhan Shashank , Singhal Maneesh , Ranganathan Kavitha 
Published: April 2024

Background
Burns constitute a major global health challenge, causing over 11 million injuries and 300,000 deaths annually and surpassing the economic burden of cervical cancer and HIV combined. Despite this, patient-level financial consequences of burn injuries remain poorly quantified, with a significant gap in data from low- and middle-income countries. In this study, we evaluate financial toxicity in burn patients.

Methods
A prospective, multicenter cohort study was conducted across two tertiary care hospitals in India, assessing 123 adult surgical in-patients undergoing operative interventions for burn injuries. Patient sociodemographic, clinical, and financial data were collected through surveys and electronic records during hospitalization and at 1, 3, and 6 months postoperatively. Out-of-pocket costs (OOPCs) for surgical burn treatment were evaluated during hospitalization. Longitudinal changes in income, employment status, and affordability of basic subsistence needs were assessed at the 1-, 3-, and 6-month postoperative time point. Degree of financial toxicity was calculated using a combination of the metrics catastrophic health expenditure and financial hardship. Development of financial toxicity was compared by sociodemographic and clinical characteristics using logistic regression models.

Results
Of the cohort, 60% experienced financial toxicity. Median OOPCs was US$555.32 with the majority of OOPCs stemming from direct nonmedical costs (US$318.45). Cost of initial hospitalization exceeded monthly annual income by 80%. Following surgical burn care, income decreased by US$318.18 within 6 months, accompanied by a 53% increase in unemployment rates. At least 40% of the cohort consistently reported inability to afford basic subsistence needs within the 6-month perioperative period. Significant predictors of developing financial toxicity included male gender (odds ratio, 4.17; 95% confidence interval, 1.25–14.29; P = 0.02) and hospital stays exceeding 20 days (odds ratio, 11.17; 95% confidence interval, 2.11–59.22; P ≤ 0.01).

Conclusions
Surgical treatment for burn injuries is associated with substantial financial toxicity. National and local policies must expand their scope beyond direct medical costs to address direct nonmedical and indirect costs. These include burn care insurance, teleconsultation follow-ups, hospital-affiliated subsidized lodging, and resources for occupational support and rehabilitation. These measures are crucial to alleviate the financial burden of burn care, particularly during the perioperative period.
An Evolving Landscape
Authors: Black Grant G. , Chen Yunchan , Qin Nancy , Wang Marcos Lu , Huang Hao , Otterburn David M. 
Published: April 2024

Purpose
Loss of breast sensation after mastectomy has been well documented. Postoperative reinnervation of the breast is influenced by factors including reconstructive technique, patient comorbidities, and adjuvant treatment. However, little attention has been paid to the differences in sensation across regions of the breast and the impact of reconstructive method on these regional differences over time.

Methods
Patients undergoing nipple-sparing mastectomy with immediate autologous or alloplastic reconstruction were prospectively followed. Neurosensory testing was performed in 9 breast regions using a pressure-specified sensory device. Patients were stratified by reconstructive technique, and regional sensation was compared at different preoperative and postoperative time points using Student t tests.

Results
One hundred ninety-two patients were included; 106 underwent autologous reconstruction via neurotized deep inferior epigastric artery perforator flap, and 86 underwent 2-stage alloplastic reconstruction. Preoperative sensation thresholds did not differ between reconstructive cohorts in any region and averaged 18.1 g/mm2. In the first year after mastectomy, decreased sensation was most pronounced in the inner breast regions and at the nipple areolar complex (NAC) in both reconstructive cohorts. At 4 years postoperatively, sensation increased the most at the NAC in the alloplastic cohort (34.0 g/mm2 decrease) and at the outer lateral region in the autologous cohort (30.4 g/mm2 threshold decrease). The autologous cohort experienced improved sensation compared with the alloplastic cohort in 5 of 9 regions at 1 year postoperatively, and in 7 of 9 regions at 4 years postoperatively; notably, only sensation at the outer superior and outer medial regions did not differ significantly between cohorts at 4 years postoperatively.

Conclusions
Although patients undergoing breast reconstruction experience increased breast sensation over time, the return of sensation is influenced by type of reconstruction and anatomic region. Regions closer to and at the NAC experience the greatest loss of sensation after mastectomy, although the NAC itself undergoes the most sensation recovery of any breast region in those with alloplastic reconstruction.
Autologous reconstruction via a neurotized deep inferior epigastric artery perforator flap results in increased return of sensation compared with alloplastic reconstruction, particularly in the inferior and lateral quadrants of the breast.