bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of Case‐Control Age‐at‐Onset Data Using a Modified Case‐Cohort Method
Authors: Nan Bin , Lin Xihong 
Published: March 2008

AbstractCase‐control designs are widely used in rare disease studies. In a typical case‐control study, data are collected from a sample of all available subjects who have experienced a disease (cases) and a sub‐sample of subjects who have not experienced the disease (controls) in a study cohort. Cases are oversampled in case‐control studies. Logistic regression is a common tool to estimate the relative risks of the disease with respect to a set of covariates. Very often in such a study, information of ages‐at‐onset of the disease for all cases and ages at survey of controls are known. Standard logistic regression analysis using age as a covariate is based on a dichotomous outcome and does not efficiently use such age‐at‐onset (time‐to‐event) information. We propose to analyze age‐at‐onset data using a modified case‐cohort method by treating the control group as an approximation of a subcohort assuming rare events. We investigate the asymptotic bias of this approximation and show that the asymptotic bias of the proposed estimator is small when the disease rate is low. We evaluate the finite sample performance of the proposed method through a simulation study and illustrate the method using a breast cancer case‐control data set. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Mechanistic Insights into the Cobalt‐Mediated Radical Polymerization (CMRP) of Vinyl Acetate with Cobalt(III) Adducts as Initiators
Authors: Debuigne Antoine , Champouret Yohan , Jérôme Robert , Poli Rinaldo , Detrembleur Christophe 
Published: March 2008

AbstractOver the past few years, cobalt‐mediated radical polymerization (CMRP) has proved efficient in controlling the radical polymerization of very reactive monomers, such as vinyl acetate (VAc). However, the reason for this success and the intimate mechanism remained basically speculative. Herein, two mechanisms are shown to coexist: the reversible termination of the growing poly(vinyl acetate) chains by the Co(acac)2 complex (acac: acetylacetonato), and a degenerative chain‐transfer process. The importance of one contribution over the other strongly depends on the polymerization conditions, including complexation of cobalt by ligands, such as water and pyridine. This significant progress in the CMRP mechanism relies on the isolation and characterization of the very first cobalt adducts formed in the polymerization medium and their use as CMRP initiators. The structure proposed for these adducts was supported by DFT calculations. Beyond the control of the VAc polymerization, which is the best ever achieved by CMRP, extension to other monomers and substantial progress in macromolecular engineering are now realistic forecasts.
Preparation and luminescence of SrAl2O4: Eu2+,Dy3+ phosphors coated with maleic anhydride
Authors: Yu Shengfei , Pi Pihui , Wen Xiufang , Cheng Jiang , Yang Zhuoru 
Published: March 2008

AbstractIn this paper, maleic anhydride is directly coated on the surface of SrAl2O4: Eu2+, Dy3+ (SAO‐ED) phosphors by an interfacial coordination chemistry method. Fourier transform infrared spectroscopy (FTIR), X‐ray photoelectron spectra (XPS), X‐ray diffraction (XRD), and scanning electron microscopy (SEM) methods are used to characterize the coating. The experimental result shows that a dense coating layer is consisting of maleic anhydride coordination with metal ions on the surface of the phosphors and the coating process does not destroy the crystal structure of the phosphors. It is also found that the introduction of maleic anhydride does not change the excitation and emission spectra of SAO‐ED phosphors, but decreases the luminous intensity, which is verified by the photoluminescence (PL) measurement. Afterglow delay curves show that the initial brightness of coated SAO‐ED phosphors decreases, but the afterglow decay rate of coated phosphors is slower than that of uncoated phosphors after they both are immersed into water for one month. This indicates that the coating layer protects the phosphors and the crystal structure of coated phosphors in water was not destroyed.
Describing and predicting psychological distress after colorectal cancer
Authors: Lynch Brigid M. , Steginga Suzanne K. , Hawkes Anna L. , Pakenham Ken I. , Dunn Jeff 
Published: March 2008

AbstractBACKGROUND.Psychological distress in cancer survivors can be detrimental to treatment adherence and self‐care tasks and is associated with poor health behaviors and decreased overall quality of life. The prevalence, course, and predictors of psychological distress after the diagnosis of colorectal cancer are to date not well described.METHODS.A prospective survey of 1822 colorectal cancer patients was undertaken assessing psychological distress and hypothesized predictors including optimism, cancer threat appraisal, social support, and physical activity at 6 and 12 months postdiagnosis. Logistic regression identified correlates of psychological distress at 12 months postdiagnosis.RESULTS.The prevalence of global psychological distress was low: 8.3% and 6.7% at 6 and 12 months postdiagnosis, respectively. When baseline measures of independent variables were included in a logistic regression model, distress at 6 months postdiagnosis (odds ratio [OR] = 10.84), comorbidities (OR = 1.64), optimism (OR = 0.93), cancer threat appraisal (OR = 0.92), and social support (OR = 0.94) were significantly associated with distress at 12 months postdiagnosis. A second logistic regression model that included concurrent measures of cancer threat appraisal, social support, and physical activity found that distress at 6 months postdiagnosis (OR = 12.49), comorbidities (OR = 1.64), optimism (OR = 0.94), and concurrent cancer threat appraisal (OR = 0.85) were significantly associated with distress at 12 months postdiagnosis.CONCLUSIONS.Distress screening at regular intervals is needed to efficiently detect colorectal cancer patients who require in‐depth psychological intervention. Threat appraisal is a modifiable variable that should be included in interventions for colorectal cancer survivors. Further research is needed to investigate the potential for physical activity to reduce distress after cancer. Cancer 2008. © 2008 American Cancer Society.
Glutamatergic networks in the Ciona intestinalis larva
Authors: Horie Takeo , Kusakabe Takehiro , Tsuda Motoyuki 
Published: March 2008

AbstractGlutamate is a major neurotransmitter in the excitatory synapses of both vertebrate and invertebrate nervous systems and is involved in many neural processes including photo‐, mechano‐, and chemosensations, neural development, motor control, learning, and memory. We identified and characterized the gene (Ci‐VGLUT) encoding a member of the vesicular glutamate transporter subfamily, a specific marker of glutamatergic neurons, in the ascidian Ciona intestinalis. The Ci‐VGLUT gene is expressed in the adhesive organ, the epidermal neurons, and the brain vesicle, but not in the visceral ganglion. The Ci‐VGLUT promoter and an anti‐Ci‐VGLUT antibody were used to analyze the distribution and axonal connections of prospective glutamatergic neurons in the C. intestinalis larva. The green fluorescent protein (GFP) reporter driven by the 4.6‐kb upstream region of Ci‐VGLUT recapitulated the endogenous gene expression patterns and visualized both the cell bodies and neurites of glutamatergic neurons. Papillar neurons of the adhesive organs, almost all epidermal neurons, the otolith cell, and ocellus photoreceptor cells were shown to be glutamatergic. Each papillar neuron connects with a rostral epidermal neuron. Axons from rostral epidermal neurons, ocellus photoreceptor cells, and neurons underlying the otolith terminate in the posterior brain vesicle. Some caudal epidermal neurons also send long axons toward the brain vesicle. The posterior brain vesicle contains a group of Ci‐VGLUT‐positive neurons that send axons posteriorly to the visceral ganglion. Our results suggest that glutamatergic neurotransmission plays a major role in sensory systems and in the integration of the sensory inputs of the ascidian larva. J. Comp. Neurol. 508:249–263, 2008. © 2008 Wiley‐Liss, Inc.
Reliable and efficient multicast protocol for mobile IP networks
Authors: Yoo Sang‐Jo , Cho Hyung‐Sang 
Published: March 2008

AbstractTo provide a multicasting service, several multicast protocols for mobile hosts (MHs) have been proposed. However, all of these protocols have faults, such as non‐optimal delivery routes and data loss when hosts move to another network, resulting in insecure multicast data transmissions. Thus, this paper presents a new reliable and efficient multicast routing protocol for mobile IP networks. The proposed protocol provides a reliable multicast transmission by compensating the data loss from the previous mobile agent when a MH moves to another network. In addition, an additional function allows for direct connection to the multicast tree according to the status of agents, thereby providing a more efficient and optimal multicast path. The performance of the proposed protocol is confirmed based on simulations under various conditions. Copyright © 2008 John Wiley & Sons, Ltd.
Synthesis of Diazaheterocyclic Ring‐Fused 1,2,4‐Benzothiadiazine 1,1‐Dioxides by a Sequential Aza‐Wittig/NH‐Addition Cyclization/Nucleophilic Ring‐Closure Methodology with N‐Alkenyl‐2‐carbodiimidobenzenesulfonamides as Key Intermediates
Authors: Hirota Shinsuke , Kato Ryo , Suzuki Madoka , Soneta Yuji , Otani Takashi , Saito Takao 
Published: March 2008

AbstractTreatment of N‐alkenyl‐2‐azidobenzenesulfonamides with triphenylphosphane and subsequent subjection of the resulting iminophosphoranes to aza‐Wittig reactions with isocyanates generated functionalized carbodiimides, which spontaneously underwent cyclization to form 2‐alkenyl‐3‐(R2‐substituted amino)‐2H‐1,2,4‐benzothiadiazine 1,1‐dioxides by internal nucleophilic addition. Subsequent (tandem) cyclizations through iodoamination or hydroamination with HgII/NaBH4 produced a variety of diazaheterocyclic ring‐fused benzothiadiazine dioxides. In one case a methano‐bridged benzothiatriazabicyclotridecanone was obtained. The scope and limitations of these cyclizations are reported. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Serum proteomic analysis during nicotine self‐administration, extinction and relapse in rats
Authors: Cecconi Daniela , Tessari Michela , Willé David R. , Zoli Michele , Domenici Enrico , Righetti Pier Giorgio , Carboni Lucia 
Published: March 2008

AbstractNicotine dependence is known to induce long‐term neural adaptations in brain. The purpose of this study was to verify whether specific protein patterns related to nicotine self‐administration states could also be detected in a peripheral tissue. A serum proteomic analysis was performed by 2‐DE on samples taken at six time points: N, naïve; P, priming; S, self‐administration; W, withdrawal; E, extinction; R, relapse. After image analysis, spot volume values were submitted to a principal component analysis and relevant comparisons were selected. In N versus S; S versus W; E versus R; S versus R and S versus E comparisons a clear separation between groups could be observed, suggesting that each self‐administration state correlates with a specific protein expression pattern. Partial least squares discriminant analysis was adopted to rank proteins by the contribution to the overall separation. A number of spots were identified; among them, C reactive protein and haemopexin displayed a significant reduction after nicotine administration; two haemopexin isoforms were decreased in the S state and antithrombin III was increased in the E phase. This study showed that specific protein patterns related to the nicotine self‐administration states exist in serum. Further development of this approach may provide biomarkers to assess dependence states of drug‐taking individuals.
Enantiomeric separations of binaphthyl derivatives by capillary electrophoresis using N‐(2‐hydroxydodecyl)‐L‐threonine as chiral selector: Effect of organic additives
Authors: Ghosh Arjun , Dey Joykrishna 
Published: March 2008

AbstractThe chiral selectivity of a novel amphiphile, N‐(2‐hydroxydodecyl)‐L‐threonine (2‐HDT), was evaluated for enantiomeric resolution of three binaphthyl derivatives (±)−1,1′‐bi‐2‐naphthol, (±)−1,1′‐binaphthyl‐2,2′‐diamine, and (±)−1,1′‐binaphthyl‐2,2′‐diylhdrogen phosphate (BNP) by micellar EKC. The effects of three organic modifiers, methanol, isopropanol, and acetonitrile, on the separations of enantiomers of these compounds were investigated. Separation of enantiomers could be achieved in relatively dilute solutions of the pure surfactant. However, best separations of enantiomers were obtained only in the presence of 10% v/v acetonitrile. Enantiomeric impurity in nonracemic mixtures of R‐ and S‐forms of BNP was determined.
A generalization of Rubinstein's “Pay now, choose later”
Authors: Guo Jia‐Hau , Hung Mao‐Wei 
Published: March 2008

AbstractThis article provides quasi‐analytic pricing formulae for forward‐start options under stochastic volatility, double jumps, and stochastic interest rates. Our methodology is a generalization of the Rubinstein approach and can be applied to several existing option models. Properties of a forward‐start option may be very different from those of a plain vanilla option because the entire uncertainty of evolution of its price is cut off by the strike price at the time of determination. For instance, in contrast to the plain vanilla option, the value of a forward‐start option may not always increase as the maturity increases. It depends on the current term structure of interest rates. © 2008 Wiley Periodicals, Inc. Jrl Fut Mark 28:488–515, 2008
Volatility dynamics of NYMEX natural gas futures prices
Authors: Suenaga Hiroaki , Smith Aaron , Williams Jeffrey 
Published: March 2008

AbstractWe examine the volatility dynamics of NYMEX natural gas futures prices via the partially overlapping time‐series model of Smith (2005. Journal of Applied Econometrics, 20, 405–422). We show that volatility exhibits two important features: (1) volatility is greater in the winter than in the summer, and (2) the persistence of price shocks and, hence, the correlations among concurrently traded contracts, displays substantial seasonal and cross‐sectional variation in a way consistent with the theory of storage. We demonstrate that, by ignoring the seasonality in the volatility dynamics of natural gas futures prices, previous studies have suggested sub‐optimal hedging strategies. © 2008 Wiley Periodicals, Inc. Jrl Fut Mark 28:438–463, 2008
DNA copy number alterations and expression of relevant genes in triple‐negative breast cancer
Authors: Han Wonshik , Jung Eun‐Mi , Cho Jihyoung , Lee Jong Won , Hwang Ki‐Tae , Yang Song‐Ju , Kang Jason Jongho , Bae Ji‐Yeon , Jeon Yoon Kyung , Park In‐Ae , Nicolau Monica , Jeffrey Stefanie S. , Noh Dong‐Young 
Published: March 2008

AbstractTriple‐negative breast cancer (TNBC) is defined by a lack of expression of estrogen, progesterone, and HER2 receptors, and genetically most of them fall into the basal subgroup of breast cancer. The important issue of TNBC is poorer clinical outcome and absence of effective targeted therapy. In this study, we sought to identify DNA copy number alterations and expression of relevant genes characteristic of TNBC to discover potential therapeutic targets. Frozen tissues from 114 breast cancers were analyzed using high‐resolution array comparative genomic hybridization. The classification into subtype was determined by estrogen and progesterone receptor expression, and by the presence or absence of gain on the ERBB2 containing clone. The ACE algorithm was used for calling gain and loss of clones. Twenty‐eight cases (25%) were classified as TNBC. Recurrent gains (≥25%) unique to TNBC were 9p24‐p21, 10p15‐p13, 12p13, 13q31‐q34, 18q12, 18q21‐q23, and 21q22. Two published gene expression array data sets comparing basal subtype versus other subtype breast cancers were used for searching candidate genes. Of the genes upregulated in the basal subtype, 45 of 686 genes in one data set and 59 of 1,428 in the second data set were found to be located in the gained regions. Of these candidate genes, gain of NFIB (9p24.1) was specific for TNBC in a validation set by real‐time PCR. In conclusion, we have identified recurrently gained regions characteristic of TNBC, and found that NFIB copy number and expression is increased in TNBC across the data sets. This article contains Supplementary Material available at http://www.interscience.wiley.com/jpages/1045‐2257/suppmat. © 2008 Wiley‐Liss, Inc.
High‐resolution copy number and gene expression microarray analyses of head and neck squamous cell carcinoma cell lines of tongue and larynx
Authors: Järvinen Anna‐Kaarina , Autio Reija , Kilpinen Sami , Saarela Matti , Leivo Ilmo , Grénman Reidar , Mäkitie Antti A. , Monni Outi 
Published: March 2008

AbstractGene amplifications and deletions are frequent in head and neck
squamous cell carcinomas (SCC) but the association of these alterations with gene expression is mostly unknown. Here, we characterized genome‐wide copy number and gene expression changes on microarrays for 18 oral tongue SCC (OTSCC) cell lines. We identified a number of altered regions including nine high‐level amplifications such as 6q12‐q14 (CD109, MYO6), 9p24 (JAK2, CD274, SLC1A1, RLN1), 11p12‐p13 (TRAF6, COMMD9, TRIM44, FJX1, CD44, PDHX, APIP), 11q13 (FADD, PPFIA1, CTTN), and 14q24 (ABCD4, HBLD1, LTBP2, ZNF410, COQ6, ACYP1, JDP2) where 9% to 64% of genes showed overexpression. Across the whole genome, 26% of the amplified genes had associated overexpression in OTSCC. Furthermore, our data implicated that OTSCC cell lines harbored similar genomic alterations as laryngeal SCC cell lines we have previously analyzed, suggesting that despite differences in clinicopathological features there are no marked differences in molecular genetic alterations of these two HNSCC sites. To identify genes whose expression was associated with copy number increase in head and neck SCC, a statistical analysis for oral tongue and laryngeal SCC cell line data were performed. We pinpointed 1,192 genes that had a statistically significant association between copy number and gene expression. These results suggest that genomic alterations with associated gene expression changes play an important role in the malignant behavior of head and neck SCC. The identified genes provide a basis for further functional validation and may lead to the identification of novel candidates for targeted therapies. This article contains Supplementary Material available at http://www.interscience.wiley.com/jpages/1045‐2257/suppmat. © 2008 Wiley‐Liss, Inc.
A randomised controlled trial of cognitive behaviour therapy vs treatment as usual in the treatment of mild to moderate late life depression
Authors: Laidlaw Ken , Davidson Kate , Toner Hugh , Jackson Graham , Clark Stella , Law Jim , Howley Mary , Bowie Gillian , Connery Hazel , Cross Susan 
Published: March 2008

AbstractObjectivesThis study provides an empirical evaluation of Cognitive Behaviour Therapy (CBT) alone vs Treatment as usual (TAU) alone (generally pharmacotherapy) for late life depression in a UK primary care setting.MethodGeneral Practitioners in Fife and Glasgow referred 114 Participants to the study with 44 meeting inclusion criteria and 40 participants providing data that permitted analysis. All participants had a diagnosis of mild to moderate Major Depressive Episode. Participants were randomly allocated to receive either TAU alone or CBT alone.ResultsParticipants in both treatment conditions benefited from treatment with reduced scores on primary measures of mood at end of treatment and at 6 months follow‐up from the end of treatment. When adjusting for differences in baseline scores, gender and living arrangements, CBT may be beneficial in levels of hopelessness at 6 months follow‐up. When evaluating outcome in terms of numbers of participants meeting Research Diagnostic Criteria for depression, there were significant differences favouring the CBT condition at the end of treatment and at 3 months follow‐up after treatment.ConclusionsCBT alone and TAU alone produced significant reductions in depressive symptoms at the end of treatment and at 6 months follow‐up. CBT on its own is shown to be an effective treatment procedure for mild to moderate late life depression and has utility as a treatment alternative for older people who cannot or will not tolerate physical treatment approaches for depression. Copyright © 2008 John Wiley & Sons, Ltd.
Immobilized recombinant human bone morphogenetic protein‐2 enhances the phosphorylation of receptor‐activated Smads
Authors: Yamachika Eiki , Tsujigiwa Hidetsugu , Shirasu Nobuaki , Ueno Takaaki , Sakata Yoshirou , Fukunaga Joji , Mizukawa Nobuyoshi , Yamada Masao , Sugahara Toshio 
Published: March 2008

AbstractBone morphogenetic protein (BMP)‐2 plays an important role in bone growth and regeneration; however, BMP‐2 is easily lost by diffusion through body fluid and has some inhibitory pathways. To address this problem, we previously immobilized recombinant human BMP‐2 (rhBMP‐2) on succinylated type I atelocollagen. Here, we examined the effect of immobilized rhBMP‐2 in vitro and vivo. In ST2, MC3T3‐E1, and C2C12 cells, alkaline phosphatase activity, which is a marker of osteoblast differentiation, was enhanced more by immobilized than nonimmobilized rhBMP‐2. In addition, the phosphorylation of receptor‐activated Smads, part of the signaling pathway activated by BMP‐2, was prolonged by immobilized rhBMP‐2 in these cells. Furthermore, implantation of immobilized rhBMP‐2 into the backs of rats promoted the formation of mature bone‐like structure. These results demonstrate that immobilized rhBMP‐2 has higher bioactivity than nonimmobilized rhBMP‐2, and, therefore, immobilization of rhBMP‐2 can prolong BMP signaling. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2009
Ordered tournaments and ordered triplewhist tournaments with the three person property
Authors: Abel R. J. R. , Ge Gennian 
Published: March 2008

AbstractIt is well known that an ordered tournament OWh(v) exists if and only ifv≡ 1 (mod 4),v≥ 5. An ordered triplewhist tournament onvplayers is said to have the three person property if no two games in the tournament have three common players. We briefly denote such a design as a 3POTWh(v). In this article, we show that a 3POTWh(v) exists whenever v>17 andv≡ 1 (mod 4) with few possible exceptions. We also show that an ordered whist tournament onvplayers with the three person property, denoted 3POWh(v), exists if and only ifv≡ 1 (mod 4),v≥ 9. © 2008 Wiley Periodicals, Inc. J Combin Designs 17: 39–52, 2009