bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research on the influence of power frequency magnetic field of pantograph on pacemaker wearers’ health in high-speed EMU
Authors: Tian Rui , Li Wei-Xuan , Lu Mai , Yu Li , Zhang Jia-Qi 
Published: March 2024

Abstract
When the popular means of transportation—high-speed trains meet the increasing rate of pacemaker implantation year by year, the research on the magnetic field environment on the health of pacemaker wearers in the carriage becomes an urgent problem. In this work, models of an electric multiple unit carriage with a pantograph as well as passengers with pacemakers were built by using COMSOL Multiphysics software. The B, Ein and Jin of human heart and other tissues, and the induced voltage (Vin) at the pacemaker electrode were calculated under the pantograph operating condition, so as to assess the effect of its magnetic field on the health of pacemaker wearers. The results showed that Bmax in the carriage without passengers is 121.246 μT, occurs near the window. In the carriage, the Bmax, Ein max and Jin max of heart and body, Vin at the pacemaker electrode of the passenger next to the window are greater than that in the middle of the carriage. The Bmax, Ein max and Jin max of passengers’ heart are 11.301μT, 1.613 mV/m and 139.030 μA/m2, respectively. The Bmax, Ein max and Jin max of passengers’ body are 12.597μT, 0.788 mV/m and 75.299 μA/m2, respectively. The maximum value of Vin at the tip of the pacemaker electrode of the passengers’ is 0.048 mV. The Bmax, Ein max in all tissues of passengers are much smaller than the basic limits of electromagnetic exposure to the public set by the International Commission on Non-Ionizing Radiation. Vin at the electrode tip of passengers’ pacemakers are less than the perception sensitivity set by the International Organization for Standardization. This work illustrated that the magnetic field generated by the pantograph is within the recognized accepted limits for passengers with pacemakers, but we still recommended that passengers wearing pacemakers should stay as far away from windows as possible.
How Segregation Ruins Inference: A Sociological Simulation of the Inequality Equilibrium
Authors: Mijs Jonathan J B , Usmani Adaner 
Published: March 2024

Abstract
Why do many people underestimate economic and racial inequality and maintain that theirs is a meritocratic society? Existing work suggests that people are rationalizing, misinformed, or misled. This article proposes an additional explanation: Inequality itself makes economic and racial disparities difficult to understand. In unequal societies, individuals establish their networks at formative institutions patterned by class and race. As a result, they unwittingly condition on key causal pathways when making descriptive and causal inferences about inequality. We use a simple agent-based model to show that, under circumstances typical to highly stratified societies, individuals will underestimate the extent of economic and racial inequality, downplay the importance of inherited advantages, and overestimate the relative importance of individual ability. Moreover, we show that they will both underestimate the extent of racial discrimination and overestimate its relative importance. Because segregated social worlds bias inference in these ways, all individuals (rich and poor) have principled reasons to favor less redistribution than they would if their social worlds were more integrated.
Evaluation of cerebral autoregulation of oxygen by NIRS method during postnatal transition period in term and late preterm newborns without resuscitation requirement
Authors: Ertekin Omer , Buyuktiryaki Mehmet , Isik Sehribanu , Okur Nilufer , Oguz Serife Suna 
Published: March 2024

Abstract

BACKGROUND
Pulse oximetry is commonly used to monitor arterial oxygen saturation and heart rate during the transition period and reference intervals have been determined. However, the effect of the change in arterial oxygen saturation on tissue oxygenation does not seem to be the same. So, a non-invasive method for monitoring cerebral or regional tissue oxygenation will be potentially useful for vulnerable infants. This study aims to evaluate the effectiveness of cerebral autoregulation in the first 10 min after delivery in term and late preterm newborns without resuscitation requirement.

METHODS
Cerebral tissue oxygen saturation was measured in the first 10 min after birth with near-infrared spectroscopy (NIRS) from the left forehead. Peripheral oxygen saturation was measured with pulse oximetry from the right hand and cerebral fractional tissue oxygen extraction was calculated.

RESULTS
Nineteen late preterms and 20 term infants were included in the study. There was no statistically significant difference between median cerebral tissue oxygen saturation and cerebral fractional tissue oxygen extraction values of late preterm and term infants (p &lt; 0.001). There was a strong inverse relationship between cerebral tissue oxygen saturation and cerebral fractional tissue oxygen extraction (p &lt; 0.001).

CONCLUSIONS
In late preterm infants similar to term infants, arterial oxygen saturation and cerebral tissue oxygen saturation increased with time, but inverse reduction of cerebral fractional tissue oxygen extraction showed the presence of an active autoregulation in the brain. This can be interpreted as the ability of the brain to protect itself from hypoxia by regulating oxygen uptake during normal fetal-neonatal transition process. A larger scale multi-center randomized control trial is now needed to further inform practice.
Thiosulfinate Tolerance Gene Clusters Are Common Features of Burkholderia Onion Pathogens
Authors: Paudel Sujan , Zhao Mei , Stice Shaun P. , Dutta Bhabesh , Kvitko Brian H. 
Published: March 2024

Burkholderia gladioli pv. alliicola, B. cepacia, and B. orbicola are common bacterial pathogens of onion. Onions produce organosulfur thiosulfinate defensive compounds after cellular decompartmentalization. Using whole-genome sequencing and in silico analysis, we identified putative thiosulfinate tolerance gene (TTG) clusters in multiple onion-associated Burkholderia species similar to those characterized in other Allium-associated bacterial endophytes and pathogens. Sequence analysis revealed the presence of three Burkholderia TTG cluster types, with both Type A and Type B being broadly distributed in B. gladioli, B. cepacia, and B. orbicola in both the chromosome and plasmids. Based on isolate natural variation and generation of isogenic strains, we determined the in vitro and in vivo contribution of TTG clusters in B. gladioli, B. cepacia, and B. orbicola. The Burkholderia TTG clusters contributed to enhanced allicin tolerance and improved growth in filtered onion extracts by all three species. TTG clusters also made clear contributions to B. gladioli foliar necrosis symptoms and bacterial populations. Surprisingly, the TTG cluster did not contribute to bacterial populations in onion bulb scales by these three species. Based on our findings, we hypothesize onion-associated Burkholderia may evade or inhibit the production of thiosulfinates in onion bulb tissues. [Formula: see text] Copyright © 2024 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license .
The Lipid Intensive Drug Therapy for Sepsis Phase II Pilot Clinical Trial*
Authors: Guirgis Faheem W. , Black Lauren Page , Henson Morgan , Bertrand Andrew , DeVos Elizabeth , Ferreira Jason , Gao Hanzhi , Wu Samuel S. , Leeuwenburgh Christiaan , Moldawer Lyle , Moore Frederick , Reddy Srinivasa T. 
Published: March 2024

OBJECTIVES:
Low cholesterol levels in early sepsis patients are associated with mortality. We sought to test if IV lipid emulsion administration to sepsis patients with low cholesterol levels would prevent a decline or increase total cholesterol levels at 48 hours.

DESIGN:
Phase II, adaptive, randomized pilot clinical trial powered for 48 patients.

SETTING:
Emergency department or ICU of an academic medical center.

PATIENTS:
Sepsis patients (first 24 hr) with Sequential Organ Failure Assessment greater than or equal to 4 or shock.

INTERVENTIONS:
Patients meeting study criteria, including screening total cholesterol levels less than or equal to 100 mg/dL or high-density lipoprotein cholesterol (HDL-C) + low-density lipoprotein cholesterol (LDL-C) less than or equal to 70 mg/dL, were randomized to receive one of three doses of lipid emulsion administered twice in 48 hours or no drug (controls). The primary endpoint was a change in serum total cholesterol (48 hr – enrollment) between groups.

MEASUREMENTS AND MAIN RESULTS:
Forty-nine patients were enrolled and randomized. Two patients randomized to lipid emulsion were withdrawn before drug administration. Data for 24 control patients and 23 lipid emulsion patients were analyzed. The mean change in total cholesterol from enrollment to 48 hours was not different between groups and was 5 mg/dL (sd 20) for lipid emulsion patients, and 2 mg/dL (sd 18) for control patients (p = 0.62). The mean changes in HDL-C and LDL-C were similar between groups. Mean change in triglycerides was elevated in lipid emulsion patients (61 mg/dL, sd 87) compared with controls (20 mg/dL, sd 70, p = 0.086). The 48-hour change in SOFA score was –2 (interquartile range [IQR] –4, –1) for control patients and –2 (IQR –3, 0) for lipid emulsion patients (p = 0.46).

CONCLUSIONS:
Administration of IV lipid emulsion to early sepsis patients with low cholesterol levels did not influence change in cholesterol levels from enrollment to 48 hours.
Examining Associations Between Baseline Health-Related Quality of Life and Depression and Physical Functioning Improvement Following Pulmonary Rehabilitation
Authors: Coleman Sulamunn R. M. , Menson Katherine E. , Katz Brian R. , DeSarno Michael J. , Gaalema Diann E. 
Published: March 2024

Purpose:
This study examined whether health-related quality of life (HRQL) and depression assessed prior to pulmonary rehabilitation (PR) participation (ie, at baseline) predicted change in 6-min walk distance (6MWD) from baseline to end of PR.

Methods:
Patients with pulmonary disease were consecutively referred/enrolled in a PR program from 2009-2022 (N = 503). Baseline 6MWD was assessed along with self-report measures of HRQL (St George’s Respiratory Questionnaire [SGRQ]) and depression (Geriatric Depression Scale [GDS]). The SGRQ total score was used to assess overall HRQL, and SGRQ subscales assessed pulmonary symptoms, activity limitations, and psychosocial impacts of pulmonary disease. Multiple linear regression was used to examine whether baseline SGRQ scores and depression predicted Δ6MWD.

Results:
Baseline SGRQ total score (F
(1,389)= 8.4, P= .004) and activity limitations (F
(1,388)= 4.8, P= .03) predicted Δ6MWD. Patients with an SGRQ activity limitation score ≤ 25th percentile showed the most 6MWD improvement (mean = 79.7 m, SE = 6.7), and significantly more improvement than participants scoring between the 50-75th percentiles (mean = 54.4 m, SE = 6.0) or >75th percentile (mean = 48.7 m, SE = 7.5). Patients scoring between the 25-50th percentiles (mean = 70.2 m, SE = 6.1) did not differ significantly from other groups. The SGRQ symptoms and impacts subscales were unrelated to Δ6MWD (F
(1,388)= 1.2-1.9, P> .05), as was depression (F
(1,311)= 0.0, P > .85).

Conclusions:
Patients with greater HRQL at baseline may experience greater physical functioning improvement following PR. Additional support for patients with lower HRQL (eg, adjunctive self-management interventions) may enhance PR outcomes, particularly for patients who report greater activity limitations. Alternatively, early referral to PR (ie, when less symptomatic) may also benefit physical function outcomes.
A Review of High-Intensity Interval Training in Heart Transplant Recipients
Authors: Nytrøen Kari , Rolid Katrine 
Published: March 2024

Objective:
This review reports how exercise-based rehabilitation strategies have developed over the past decades, and it specifically focuses on the effectiveness, safety, and implementation of high-intensity interval training (HIIT). It provides an overview of the historical progression, main research findings, and considerations surrounding HIIT as the preferred exercise modality for recipients of heart transplant (HTx).

Review Methods:
The review includes a timeline of studies spanning from 1976-2023. The 2017 Cochrane systematic review on exercise‐based cardiac rehabilitation in recipients of HTx serves as the main knowledge base (≥2015). Additionally, literature searches in PubMed/Medline and ClinicalTrials.gov have been performed, and all reviews and studies reporting the effects of moderate- to high-intensity exercise in recipients of HTx, published in 2015 or later have been screened.

Summary:
High-intensity interval training has gained prominence as an effective exercise intervention for recipients of HTx, demonstrated by an accumulation of performed studies in the past decade, although implementation in clinical practice remains limited. Early restrictions on HIIT in HTx recipients lacked evidence-based support, and recent research challenges these previous restrictions. High-intensity interval training results in greater improvements and benefits compared with moderate-intensity continuous training in the majority of studies. While HIIT is now regarded as generally suitable on a group level, individual assessment is still advised. The impact of HIIT involves reinnervation and central and peripheral adaptations to exercise, with variations in recipent responses, especially between de novo and maintenance recipients, and also between younger and older recipients. Long-term effects and mechanisms behind the HIIT effect warrant further investigation, as well as a focus on optimized HIIT protocols and exercise benefits.
Existing and Emerging Technologies for Therapeutic Monitoring of Lithium
Authors: Pedraza-Sanabria Santiago , Dodd Seetal , Giraldo-Cadavid Luis Fernando , Whittingham Karen , Bustos Rosa-Helena 
Published: March 2024

Abstract

Background/Purpose
Lithium is an effective psychoactive drug. It has a narrow therapeutic margin, with subtherapeutic levels or intoxication commonly occurring. Therapeutic drug monitoring (TDM) of lithium has several barriers. This scoping review aims to describe and analyze existing and emerging technologies for lithium TDM and to describe the lithium quantification parameters (precision, accuracy, detection limit) attributed to each technology.

Method
PubMed, Scopus, Web of Science, and Google Scholar were searched. Studies that described lithium quantification and complied with PRISMA-ScR guidelines were included. Articles selection was conducted by 2 researchers. Good precision was defined if its relative standard deviation <3%; acceptable, from 3% to 5%; and low, >5%. Accuracy was considered good if the error <5%; acceptable, 5%1 to 0%; and low if it was >10%.

Results
Of the 2008 articles found, 22 met the inclusion criteria. Of these, 14 studies concerned laboratory devices, in which precision was found to be low in one third of cases, and half had good precision. Accuracy of one third was good, another third was low, and the remaining third did not report accuracy. The other 8 studies concerned portable devices, in which precision was low in more than 60% of the cases and good in 25% of the studies. Accuracy was low in 50% of the cases, and good in just over a third. Limits of detection included the therapeutic range of lithium in all studies.

Conclusions
Among emerging technologies for lithium TDM, precision and accuracy remain a challenge, particularly for portable devices.
Murdered Indigenous Women: A Comparison Study of Victim and Perpetrator Patterns and Characteristics
Authors: Petreca Victor G. , Dowdell Elizabeth B. , Harding Shari L. , Mars Mak , Pudvah Emily , Jeune Johany , Burgess Ann W. 
Published: March 2024

ABSTRACT

Introduction
The rate of violent crimes against Indigenous people, including murder and rape, is significantly higher than national averages. Even more concerning, Indigenous women and girls represent a large proportion of murdered and missing individuals in the United States. In addition to the murder rate of Indigenous women being higher than the national average, they are significantly more likely to experience rape or other types of sexual violence. The main goal of this study was to gain a better understanding of cases involving the homicide of Indigenous women and identify patterns associated with the violence committed against them.

Methods
Cases of Indigenous women between the ages of 18 and 55 years were pulled from the database. Cases were coded and analyzed for information pertaining to victim, perpetrator, and crime characteristics. Descriptive analysis and test of association were performed.

Results/Findings
There was a statistical association between the nature of the relationship between perpetrators and victims and whether the crime occurred on a reservation, the race/ethnicity of the perpetrator, a victim's history of domestic violence, and the method and motive of murder.

Discussion/Conclusion
Indigenous women are at an increased risk of victimization, including intimate partner violence and homicide. They also represent a group that has been marginalized, receiving little attention from the media, clinicians, researchers, and policy makers. The findings in this study highlight specific factors that may help to mitigate risk factors and/or enhance culturally competent clinical and forensic nursing practice.
Machine learning based peri-surgical risk calculator for abdominal related emergency general surgery: a multicenter retrospective study
Authors: Chen Biao , Sheng Weiyong , Wu Zhixin , Ma Bingqing , Cao Nan , Li Xushu , Yang Jia , Yuan Xiaowei , Yan Lizhao , Zhu Gaobo , Zhou Yuanhong , Huang Zhonghua , Zhu Meiwei , Ding Xuehui , Du Hansong , Wan Yanqing , Gao Xuan , Cheng Xing , Xu Peng , Zhang Teng , Tao Kaixiong , Shuai Xiaoming , Cheng Ping , Gao Yong , Zhang Jinxiang 
Published: March 2024

Background:
Currently, there is a lack of ideal risk prediction tools in the field of emergency general surgery (EGS). The American Association for the Surgery of Trauma recommends developing risk assessment tools specifically for EGS-related diseases. In this study, we sought to utilize machine learning (ML) algorithms to explore and develop a web-based calculator for predicting five perioperative risk events of eight common operations in EGS.

Method:
This study focused on patients with EGS and utilized electronic medical record systems to obtain data retrospectively from five centers in China. Five ML algorithms, including Random Forest (RF), Support Vector Machine, Naive Bayes, XGBoost, and Logistic Regression, were employed to construct predictive models for postoperative mortality, pneumonia, surgical site infection, thrombosis, and mechanical ventilation >48 h. The optimal models for each outcome event were determined based on metrics, including the value of the Area Under the Curve, F1 score, and sensitivity. A comparative analysis was conducted between the optimal models and Emergency Surgery Score (ESS), Acute Physiology and Chronic Health Evaluation II (APACHE II) score, and American Society of Anesthesiologists (ASA) classification. A web-based calculator was developed to determine corresponding risk probabilities.

Result:
Based on 10 993 patients with EGS, we determined the optimal RF model. The RF model also exhibited strong predictive performance compared with the ESS, APACHE II score, and ASA classification. Using this optimal model, the authors developed an online calculator with a questionnaire-guided interactive interface, catering to both the preoperative and postoperative application scenarios.

Conclusions:
The authors successfully developed an ML-based calculator for predicting the risk of postoperative adverse events in patients with EGS. This calculator accurately predicted the occurrence risk of five outcome events, providing quantified risk probabilities for clinical diagnosis and treatment.
The adverse impact of perioperative body composition abnormalities on outcomes after split liver transplantation: a multicenter retrospective cohort study
Authors: Chen Hao , Hu Zhihang , Xu Qingguo , He Chiyu , Yang Xinyu , Shen Wei , Lin Zuyuan , Li Huigang , Zhuang Li , Cai Jinzhen , Lerut Jan , Zheng Shusen , Lu Di , Xu Xiao 
Published: March 2024

Background:
Split liver transplantation (SLT) increases graft availability, but it’s safe and effective utilization is insufficiently documented. This study aimed to investigate the association between perioperative body composition abnormalities and outcomes in adult SLT.

Materials and methods:
Two hundred forty recipients who underwent SLT in three centers were enrolled in this retrospective cohort study. Body composition abnormalities including sarcopenia, myosteatosis, visceral obesity, and sarcopenic obesity were evaluated at baseline and 1 month after surgery using computed tomography. Their impact on outcomes including early allograft dysfunction, early complications, ICU stay, graft regeneration rate, and survival was analyzed.

Results:
Recipients with sarcopenia or myosteatosis had a higher risk of early allograft dysfunction, higher early complication rate, and longer length of ICU stay (all P<0.05), while there was no difference in graft regeneration rate. Recipient and graft survival were significantly worse for recipients with body composition abnormalities (all P<0.05). In multivariable Cox-regression analysis, sarcopenia [hazard ratio (HR)=1.765, P=0.015], myosteatosis (HR=2.066, P=0.002), and visceral obesity (HR=1.863, P=0.008) were independently associated with shorter overall survival. Piling up of the three factors increased the mortality risk stepwise (P<0.001). Recipients experienced skeletal muscle loss and muscle fat infiltration 1 month after surgery. Postoperative worsening sarcopenia (HR=2.359, P=0.009) and myosteatosis (HR=1.878, P=0.026) were also identified as independent risk factors for mortality.

Conclusion:
Sarcopenia, myosteatosis, and their progression negatively affect outcomes including early allograft dysfunction, early complications, ICU stay and survival after SLT. Systemic evaluation and dynamic monitoring of body composition are valuable.
Microbiome and its impact on fetal and neonatal brain development: current opinion in pediatrics
Authors: Frerichs Nina M. , de Meij Tim G.J. , Niemarkt Hendrik J. 
Published: March 2024

Purpose of review
Emerging evidence suggests that the gut microbiota and its metabolites regulate neurodevelopment and cognitive functioning via a bi-directional communication system known as the microbiota-gut-brain axis (MGBA).

Recent findings
The MGBA influences brain development and function via the hypothalamic-pituitary axis, the vagal nerve, immune signaling, bacterial production of neurotransmitters, and microbial metabolites like short-chain fatty acids, tryptophan derivatives, and bile acids. Animal studies show fetal neurodevelopment is mediated by maternal microbiota derivatives, immune activation, and diet. Furthermore, manipulation of the microbiota during critical windows of development, like antibiotic exposure and fecal microbiota transplantation, can affect cognitive functioning and behavior in mice. Evidence from human studies, particularly in preterm infants, also suggests that a disrupted gut microbiota colonization may negatively affect neurodevelopment. Early microbial signatures were linked to favorable and adverse neurodevelopmental outcomes.

Summary
The link between the gut microbiota and the brain is evident. Future studies, including experimental studies, larger participant cohort studies with longitudinal analyses of microbes, their metabolites, and neurotransmitters, and randomized controlled trials are warranted to further elucidate the mechanisms of the MGBA. Identification of early, predictive microbial markers could pave the way for the development of novel early microbiota-based intervention strategies, such as targeted probiotics, and vaginal or fecal microbiota transplantation, aimed at improving infant neurodevelopment.