bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serial CEA levels in colorectal carcinoma on adjuvant immuno (chemo) therapy
Authors: Carluccio L. , Colizza S. , Costantino A. , Dipaola M. , Sopranzi N. 
Published: February 2007

AbstractSerial CEA levels have been studied preoperatively, and one day, 10–15 days, four months, and eight months after surgery in a group of colon cancer patients who started soon after surgery a protocol of adjuvant immuno(chemo)therapy with Levamisole® and BCG®. Results showed a decrease of mean values of plasma CEA levels from preoperatively to four months after surgery, while eight months after surgery a slight increase was noted. Some of the patients in whom disease recurred showed persistent high levels of CEA, while one patient was consistently a false‐negative notwithstanding a bone recurrence. While the prognostic value of serial CEA determinations is confirmed, the possibility of restarting (or intensifying) a protocol of adjuvant immunochemotherapy given high CEA levels and a negative clinical picture is discussed.
Mediastinal lymphangioma
Authors: Shenoy Sadashiv S. , Barua Nil R. , Patel Arun R. , Culver Gordon J. , Jennings Ethelyn C. 
Published: February 2007

AbstractMediastinal lymphangioma is an uncommon benign tumor accounting for 0.7 to 4.5% of all mediastinal masses. Lymphangiomas consist of dilated cystic lymph spaces lined by single layers of endothelium and do not undergo malignant change. Most mediastinal lymphangiomas are asymptomatic. There are no specific radiological findings. Surgical excision is the treatment of choice and the prognosis is excellent.
Primary malignant melanoma of the rectum: Rationale for conservative surgical management
Authors: Garnick Marc , Lokich Jacob J. 
Published: February 2007

AbstractA case of malignant melanoma arising in the rectum is described and the literature is reviewed. The natural history of melanoma of the rectum is distinctive from that of other tumors of the perineal area in that local recurrence is uncommon and systemic dissemination is frequent, with a low cure rate (2/66 in a literature review). Conservative surgical approaches (fulguration, local resection) are recommended in preference to abdominoperineal resection in that palliation is the realistic goal of surgical therapy.
An evaluation of intraabdominal involvement in hodgkin disease
Authors: Dinshaw K. A. , Advani S. H. , Desai P. B. , Jussawalla D. J. 
Published: February 2007

AbstractAn analysis of the staging procedure in 80 patients with histologically confirmed Hodgkin disease was performed at Tata Memorial Hospital, Bombay. There was a marked male preponderance. The mixed cellularity type of Hodgkin disease is the commonest histological variety (47.5%) and has the highest incidence of subsequently proven generalized disease (76%). The lymphocytic predominant variety was the next most common (27.5%) and was present as unsuspected disease in 45% of cases. Systemic symptoms were associated with advanced disease in 57% of clinical IB and 73% of clinical IIB cases. Splenic involvement was histologically confirmed in 41% of cases with stage I disease and 52% of cases with stage II disease and was associated with liver involvement in two cases. A lymphogram was performed, in addition, prior to the laparotomy in 40 cases and the lymphogram‐laparotomy concordance was approximately 72% in our series. This stresses the importance of a staging laparotomy.
Development of carcinoma of the breast at the site of an implanted pacemaker in two patients
Authors: Biran Shoshana , Keren Andre , Farkas Thomas , Stern Shlomo 
Published: February 2007

AbstractWe report here on two female patients who had permanent pacemakers implanted in their chests and who developed carcinoma of the breast subsequently. An association is suspected between the breast cancer and the pacemaker, which is implanted in an area which borders with the mammary gland or is even right within it. This suspicion led us lately to change in female patients the site of the subcutaneous pocket for the implantation of the pacemaker to a position higher in the chest than before. Moreover, we advocate frequent breast examinations in all female patients with implanted pacemakers.
Recall skin‐test antigens and the prognosis of stage I melanoma
Authors: Aranha Gerard V. , McKhann Charles F. , Simmons Richard L. , Grage Theodor B. 
Published: February 2007

AbstractThirty‐one patients with Stage I melanoma were studied with regard to their response to common skin antigens. Patients were divided into two groups, those who had surgery alone, and those who had surgery and BCG. The results were comparable. It was found that the disease‐free interval was longer and the recurrence rate lower in patients who demonstrated cutaneous hypersensitivity to common antigens than in those who did not. Patients who had Clark's levels I and II lesions were more likely to be immunocompetent. The addition of BCG in the study did not appear to decrease the rate of recurrence, which seems to be related to the basic immunological status of the individual.
Detection of cancer‐associated antigen(s) in urine of sarcoma patients
Authors: Gupta Rishab K. , Morton Donald L. 
Published: February 2007

AbstractTumor‐associated antigens were demonstrated in concentrated and dialyzed urine of several sarcoma patients with large tumor burden. The antigens were detected by complement fixation using autologous and allogeneic sera from sarcoma patients. The antigenic activity in three patients who were studied sequentially disappeared after surgical ablation of tumor. In two of these three patients, the antigenic activity reappeared before tumor recurrence. The reactivity of the sarcoma sera to the urine could be abolished by absorption of the sera with human sarcoma cells but not by normal human liver cells, which indicates that the same antigen was present in the urine and on biopsy‐obtained sarcoma cells. Urine from cancer patients with high tumor burden may be useful as a source of tumor‐associated antigen. Further studies on the presence of these antigens in urine of sarcoma patients may lead to a method for detecting subclinical tumor recurrence.
Explorations of antimitotic agents in the treatment of a congenital disease, Ichthyosis Linearis Circumflexa
Authors: Klein Edmund , Hahn Gary M. , Solomon James A. , Kim Untae , Schwartz Robert A. , Case Robert W. , Herman Hannah , Milgrom Halina , Holtermann Ole A. 
Published: February 2007

AbstractSuccessful therapy of a genetic disorder, Ichthyosis Linearis Circumflexa, was achieved using low dose systemic cyclophosphamide. Prior to such therapy, 80 to 90% of the body surface was affected; the use of antimitotic agents reduced the extent of the lesions to less than 15% of the body surface. As a result, the clinical status was changed from severely disabling to being compatible with a normal way of life. It is believed that this phenomenon is related to selective effects of cyclophosphamide, such as those on lymphocyte subpopulations. To our knowledge, successful chemotherapy for diseases of genetic or congenital origin has not been previously reported.
The spouse as facilitator for esophageal speech: A research perspective
Authors: Gibbs Harriet Weidman , Achterberg‐Lawlis Jeanne 
Published: February 2007

AbstractThe role of the spouse in relation to the quality of esophageal speech of laryngectomized patients was investigated using psychodiagnostic instruments and speech ratings and through an assessment of the verbal interactions between the patient and spouse. Analysis of the results indicates that those speakers who were objectively judged to have higher quality speech and learned esophageal speech rapidly had spouses who were more likely to disagree verbally with them, addressed them in a way that encouraged long answers, and evidenced reciprocal compatibility for meeting affectional needs.
Certain aspects of analysis of complement dependent antibody in breast cancer patients
Authors: Hindsley J. Pack , Avis Ingalill , Newsome James F. , Fried Floyd A. , Avis Frederick P. 
Published: February 2007

AbstractSpecific anti‐breast cancer complement dependent antibody (CDA) was sequentially determined in the sera of patients before and after mastectomy or during progressive recurrent breast cancer. Several observations were made. (1) There appears t o be a different pattern of antigenic cross‐reactivity detected by cancer patients' anti‐tumor CDA than by their anti‐tumor cell‐mediated immunity; the former being broader than the latter. (2) Patients can be classified into three categories: those with persistent anti‐tumor CDA pre‐and post‐mastectomy; those with detectable CDA post‐mastectomy but not premastectomy; and those with only occasionally detectable CDA. (3) Some sera obtained from patients with clinically evident tumor inhibited anti‐tumor CDA found in the sera of other cancer patients. The significance of these results are discussed.
Metastases from carcinoma of mammary gland: An autopsy study
Authors: Cifuentes Nestor , Pickren John W. 
Published: February 2007

AbstractInformation on metastases from carcinoma of the mammary gland in an autopsy study of 707 cases occurring in white women over a 15‐year period are presented and tabulated.Multiple primary cancers occurred in 19% of the cases. Of the 137 cases that exhibit more than one neoplastic malignancy, 31 (23%) were present in the contralateral mammary gland. Seventy patients had no metastasis from the mammary cancer at the time of death, and 55 of these patients had another cancer.Additional information has been added concerning the frequency of metastasis in parathyroid and thymus. When a parathyroid contains a metastasis, extensive metastases were noted in many organs and thus represents a late stage of the cancer.
Gastrointestinal carcinoids: Extrahepatic metastases and symptomatology following resection
Authors: Dilawari Raza A. , Douglass Harold O. 
Published: February 2007

AbstractOf 49 patients with midgut and hindgut carcinoids, second primary distinct carcinomas occurred in 12. The most aggressive carcinoids were the 24 that arose in the distal small bowel and cecum. Of the patients affected, 15 had lymph node metastases and eight had liver metastases at the time of diagnosis. That only five patients were completely relieved of symptoms following resection was partially explained by autopsy findings in 15 patients, six of whom had metastatic extra‐abdominal carcinoid without liver metastases (most commonly, bone metastases).
Survival rates of breast carcinoma patients after surgery and anaesthetic
Authors: Alsabti Elias 
Published: February 2007

AbstractEighty‐nine breast cancer patients were studied for the end results of therapy. During surgery, the anaesthesia administered was either halothane (61 cases) or ether (28 cases) mixture with nitrogen and oxygen. The holstead method for mastectomy was used for all cases. The results showed that the type of anaesthesia influenced the end results of therapy of breast cancer patients. The survival rates of patients receiving halothane were much higher than those of ether anaesthetized cases. The differences were most pronounced among cases who received both preoperative radiotherapy and postoperative chemotherapy, and in cases with metastasis into regional lymph node. A comparison of groups of patients on the basis of such parameters as the anaesthetic used, age and degree of tumor progression (according to TNM classification and postoperative histological assays) showed them to be well matched. These results may be explained by the effects of the anaesthesia on the role of immunity in controlling tumor cell implantation and growth of metastasis.
Steroid receptors in sarcomatous lesions
Authors: Lee Yeu‐Tsu N. , Markland Francis S. 
Published: February 2007

AbstractClinical observations showed that the natural history of sarcomatous lesions may be different among males and females, and it may be influenced by hormonal factors. Estrogen receptors (ER) were measured on biopsy specimens of melanoma (two patients), soft‐tissue sarcoma (four patients), cystosarcoma phylloides (five patients), benign breast tissues (27 patients), and breast carcinoma (109 patients). Thirty‐four specimens also had progesterone receptors (PR) analyzed. One of the five cystosarcoma phylloides and five of the six nonmammary sarcoma tissues contained ER (mainly of the 4 Svedburg (S) variety) of more than 7 femtomoles (fmoles)/mg cytosol proteins (6/11 = 54%). For comparison, three of the 14 fibroadenoma specimens and two of the 13 patients with other benign lesions had positive ERs (5/27 = 19%), whereas 56% of the breast carcinomas were ER positive. Since the amount of 8S ER found in sarcomatous tissues is relatively low, hormonal treatment would not be effective.
Relationship of race to functional status among breast cancer patients after curative surgery
Authors: Feldman Joseph G. , Gardner Bernard , Carter Anne C. , Alfonso Antonia , Orces Heriberto 
Published: February 2007

AbstractAnalysis of functional status of 197 breast cancer patients three years after curative radical mastectomy indicated a cumulative probability of disability of 25%. whereas the probability of death regardless of prior disability was 40.5%.Analysis of functional status by patient characteristics indicated that nonwhites were three times more likely than whites to experience disability (P <0.01) as defined in terms of their ability to carry on normal activities without assistance.Although whites and nonwhites were diagnosed at similar stages of disease, nonwhites were, on average, eight years younger than whites. The younger age may reflect a larger proportion of premenopausal breast cancer cases among nonwhites, which if associated with more rapidly progressing disease could account for their poorer prognosis.Alternatively, there may exist factors in the nonwhites' social or economic environment that limited the ability of the family to care for the patient at home.These data reaffirm the need to monitor closely breast cancer patients to diagnose acute complications, and they indicate that most patients can resume normal activities shortly after curative surgery.
Visceral neoplasia presenting at the umbilicus
Authors: Scarpa Francis J. , Dineen Joseph P. , Boltax Robert S. 
Published: February 2007

AbstractAn umbilical mass as the presenting and only symptom of an underlying visceral carcinoma is an infrequent occurrence. The implications of such a finding are illustrated by four examples, with primary tumors in pancreas, colon, and ovary.Adenocarcinoma in the umbilicus represents a metastatic deposit until proved otherwise. Further diagnostic evaluation to localize the primary tumor should be based upon therapeutic implications. The need for abdominal exploration must be individualized.
Septic arthritis: A complication of BCG immunotherapy
Authors: Lokich Jacob J. , Drew Michael A. 
Published: February 2007

AbstractA new complication of cutaneous vaccination for immune therapy is reported: non‐acid‐fast bacteremia with metastatic septic arthritis. Systemic antibiotics should be administered prophylactically in patients with signs and symptoms of local infection, particularly in the presence of orthopedic prostheses or valvular heart disease.
Comparison of DES vs DES + chlorambucil in women with first recurrence of breast cancer
Authors: Holzer Donald , Harvey Harold A. , Lipton Allan 
Published: February 2007

AbstractThirty‐four women with first recurrence of breast cancer were randomized into two groups, and received either Diethystilbesterol (DES) 5 mg orally (PO) t.i.d. alone, or in combination with Chlorambucil (CB) 0.1–0.2 mg/kg/day PO. All patients randomized were greater than 5 years postmenopausal at the time of the study and had no prior chemical or hormonal therapy. Estrogen receptors were not available. There was no significant difference between Groups A and B with respect to frequency of objective response or mean duration of that response, with the values for Group A being 46.2% and 4.8 months, respectively, and for Group B, 46.7% and 4.8 months (P > 0.05). The most common toxicities noted for both groups were nausea and vomiting, edema, weakness, and thrombophlebitis. The risk of major toxicity necessitating withdrawal from the study was greater in Group B due to the added danger of thrombocytopenia/pancytopenia. The addition of CB to DES does not appear to offer any significant advantage over DES alone in women with first recurrence of breast cancer.
Fibrosarcoma of the mediastinum
Authors: Barua Nil R. , Patel Arun R. , Takita Hiroshi , Jennings E. C. 
Published: February 2007

AbstractFibrosarcoma is a rare primary malignant tumor of the mediastinum. Three cases are presented with different presenting symptoms and clinical manifestations. Thoracotomy with biopsy of the mass is the only method for arriving at a definitive histologic diagnosis.
Primary malignant melanoma of the esophagus: Report of two cases
Authors: Jawalekar Kshama , Tretter Patricia 
Published: February 2007

AbstractTwo cases of primary esophageal malignant melanoma diagnosed at the Columbia‐Presbyterian Medical Center are reported. One patient who received 3800 rads and had subsequent surgery lived for 18 months. The other had surgery and subsequent chemotherapy and is still alive three years later. Forty other cases reported in the literature are briefly analyzed.
Non‐specific and specific active immunotherapy in a B16 murine melanoma system
Authors: Avent J. , Vervaert C. , Seigler H. F. 
Published: February 2007

AbstractConflicts amongst reports concerning the efficacy of both nonspecific and specific attempts at immunotherapy may be ascribed to different animal models utilizing tumors of different immunogenicity. We have selected the B16 mouse melanoma model as the example of a spontaneously occurring neoplasm that is histocompatible with the host and does have tumor‐associated antigens. Attempts to alter tumor growth or survival with nonspecific active immunotherapy as well as with specific active immunotherapy were not successful. Nonspecific active pre‐immunization failed to alter tumor take or growth. Specific active immunotherapy both with and without adjuvant did decrease tumor take and prolong host survival. The effects were increasingly documented at lower tumor cell inoculums and became less apparent with increase in the tumor cell challenge.
Malignant fibrous histiocytoma arising in a patient with multiple neurofibromatosis: A case report and a literature review
Authors: Johnson Paul S. , Katz David Allan , Pester Judith , Penn Robert 
Published: February 2007

AbstractA case report of a 56‐year‐old man with the characteristic clinical and histologic features of multiple neurofibromatosis is presented. This patient was also diagnosed as having a malignant fibrous histiocytoma involving the right thigh with metastasis to the lung. A definite association between Von Reckling‐hausen's disease and various sarcomas (most commonly neurofibrosarcomas) of the peripheral nerves and the somatic soft tissues is well‐known. This is apparently the first report in the literature of a malignant fibrous histiocytoma arising in a patient with multiple neurofibromatosis. The phenomenon of sarcomatous change in Von Recklinghausen's disease and the clinical and pathologic features of malignant fibrous histiocytoma are also discussed.
Gliomatosis peritonei: The value of a “second look” operation
Authors: Heydenrych J. J. , Villet W. T. , Du Toit D. F. 
Published: February 2007

AbstractThe case history of a 10‐year‐old black girl with gliomatosis peritonei, Grade 0, is presented. The primary tumour was resected and a “second look” operation carried out 3 months later. The glial implants demonstrated distinct circumferential and intra glial fibrosis (resolution). Because the peritoneal implants had undergone resolution, further therapy became unnecessary.We believe gliomatosis peritonei fully justifies a second laparotomy in order to be able to accurately grade the implants. The grade of the peritoneal implants influences the prognosis and therefore determines the type of therapy to be instituted.
Mutilating sclerosing basal cell epithelioma
Authors: Schwartz Robert Allen , Vickerman Charles E. , Phelan John T. , Burgess Gordon H. , Klein Edmund , Solomon James , O'Loughlin Sean , Southwick Graeme J. , Baitman Linda , Laor Yona 
Published: February 2007

AbstractA 59‐year‐old black woman presented with an ill‐defined plaque on her nose. This appeared clinically suggestive of a sclerosing type of basal cell epithelioma (BCE). Microscopic sections demonstrated this diagnosis. Multiple excisions employing the microscopically controlled technique of Mohs traced the tumor deep into the nasal cartilage before histologic sections were free of tumor cells. This type of BCE deserves well planned therapy because of its destructive potential.
Serum immunoglobulins in women with breast cancer
Authors: Papatestas Angelos E. , Bramis John , Aufses Arthur H. 
Published: February 2007

AbstractSerum immunoglobulins were determined in 120 women with breast cancer. A strong association between age at tumor diagnosis and serum IgA levels was noted. Relative hypoglobulinemia of IgA was associated with appearance of tumors early in life, and was more frequent among women with family history of breast cancer and among those with poor prognosis. A strong association between levels of serum IgG and parity was noted. Parous women and/or those who had good prognosis had higher levels of serum IgG, compared to nulliparous women and those with poor prognosis. The observations indicate that serum immunoglobulins may be useful in the identification of women who have a high breast cancer risk and poor prognosis.
Chronic hematuria and localized bladder damage following combined cyclophosphamide and local radiotherapy
Authors: Kende George , Wajsman Zew , Thomas Patrick R. M. , Freeman Arnold I. 
Published: February 2007

AbstractA 13‐year‐old white male had Ewing sarcoma of the right pubic and ischial bones. Initial therapy consisted of 5,400 rads in seven weeks to the right side of the pelvis and 14 intravenous injections of cyclophosphamide (Cytoxan, CTX) at 500 mg/m2; BCNU and Adriamycin maintenance therapy continued for a total of two years. He has now been disease‐free for five years.Three months following the completion of the right pelvic radiotherapy (RT), while on intravenous CTX, severe hematuria appeared, which subsided, but at present he has continuous microscopic hematuria, as well as periodic episodes of gross hematuria.Serial cystocopies initially revealed thickening and hemorrhagic and edematous changes on the right (irradiated) side of the bladder, and recent multiple telangiectatic patches have been demonstrated as a late “healing” phase.This case demonstrates the additive toxicity to the bladder of CTX and RT, illustrating that the hemorrhagic cystitis can be extremely protracted lasting five years.
Epidermoid carcinoma of the breast
Authors: Farrand R. , Lavigne R. , Lokich J. , McAuley R. , Sparling S. , Rollo Q. , Walker G. 
Published: February 2007

AbstractTwo patients with squamous cell carcinoma of the breast are described. In one patient the lesion represented a primary breast tumor; in the second, a metastases from primary bronchogenic carcinoma. Neither lesion possessed estrogen receptor protein. This report emphasizes the rarity of epidermoid lesions of the breast and the importance of identifying an extramammary primary source of metastases to the breast.