bluuebunny/crossref_metadata_2025_split huggingface dataset:
A layered architecture for flexible Web service invocation
Authors: De Antonellis Valeria , Melchiori Michele , De Santis Luca , Mecella Massimo , Mussi Enrico , Pernici Barbara , Plebani Pierluigi 
Published: November 2005

AbstractWeb service composition is emerging as an interesting approach to integrate business applications and create intra‐organizational business processes. Single Web services are combined to create a complex Web service that will realize the process business logic. Once the process is created, it is executed by an orchestration engine that invokes individual Web services in the correct order. However, Web services composing the workflow sometimes become unavailable during the run‐time phase, blocking process execution. This paper describes an architecture that allows the flexible orchestration of business processes. With this approach, Web services composing the process can be automatically substituted with other compatible Web services during process execution. A methodology is defined to evaluate Web service compatibility based on interface matching, in order to select substitutable Web services. Copyright © 2005 John Wiley & Sons, Ltd.
A model for second‐trimester Down syndrome sonographic screening based on facial landmarks and digit length measurement
Authors: Maymon R. , Ushakov F. , Waisman D. , Cuckle H. , Tovbin Y. , Herman A. 
Published: November 2005

AbstractObjectiveTo determine whether Down syndrome can be detected by combining measurements of fetal nasal bone (NB) length, prenasal thickness (PT) and digits 2 and 3 of the hand.MethodsTwo hundred and fifty‐four normal and 25 Down‐syndrome fetuses were scanned between 15 and 33 weeks' gestation. Physicians performing the scans were not blinded to the fetal karyotype. Both PT and NB were measured in a mid‐sagittal plane. For PT measurement calipers were placed between the frontonasal angle and the outer skin edge. Digits 2 and 3 of one hand were also measured. The results (except for PT/NB ratio) were expressed in multiples of the normal gestation‐specific median (MoM). A logistic regression model was used to estimate the odds of the fetus having Down syndrome given different combinations of NB, PT, PT/NB ratio, and digits 2 and 3 measurements. The odds were used to calculate the risk of Down syndrome for each pregnant woman from her age and measurements.ResultsThe median PT MoM for unaffected fetuses and Down‐syndrome fetuses was 1.12 vs. 1.35 (P < 0.0001). The median NB MoM for unaffected and Down‐syndrome fetuses was 1.03 vs. 0.81 (P < 0.001) and the PT/NB ratio MoM for unaffected and Down‐syndrome fetuses was 0.63 vs. 0.96 (P < 0.001). The respective median MoM values for digits 2 and 3 of the Down‐syndrome fetuses were significantly smaller (0.81 vs. 0.93 and 0.89 vs. 0.95, respectively, P = 0.003). Only the PT/NB ratio and digit 2 were finally included in the logistic regression equation. Using a 1 in 200 risk cut‐off, the observed sensitivity and false‐positive rate were 76% and 6.7%, respectively.ConclusionCombining the PT/NB ratio and digit 2 measurements yielded a promising screening detection rate. Confirmation of our findings in a prospective study is needed before the method can be used clinically. Copyright © 2005 ISUOG. Published by John Wiley & Sons, Ltd.
Metopic suture in fetuses with trisomy 21 at 11 + 0 to 13 + 6 weeks of gestation
Authors: Faro C. , Wegrzyn P. , Benoit B. , Chaoui R. , Nicolaides K. H. 
Published: November 2005

AbstractObjectiveTo investigate the development of the frontal bones and metopic suture in fetuses with trisomy 21 at 11 + 0 to 13 + 6 weeks of gestation.MethodsThree‐dimensional (3D) ultrasound was used to measure the height of and gap between the frontal bones in 75 fetuses with trisomy 21 and these were compared to the measurements in 200 normal fetuses at 11 + 0 to 13 + 6 (median, 12 + 6) weeks of gestation.ResultsIn the fetuses with trisomy 21, compared to the normal fetuses, there was no significant difference in either the height of the frontal bones (mean difference 0.16 SD, range −1.78 to 2.17 SD; P = 0.369) or the gap between them (mean difference 0.012, 95% CI −0.073 to 0.097; P = 0.780). Additionally, within the group of trisomy 21 fetuses there were no significant differences in the development of the frontal bones and metopic suture between those with absent (n = 46) and those with present (n = 29) nasal bone.ConclusionsIn trisomy 21 the development of the frontal bones and metopic suture is as normal and is independent from the development of the nasal bones. Copyright © 2005 ISUOG. Published by John Wiley & Sons, Ltd.
Interaction between tramadol and two anti‐emetics on nociception and gastrointestinal transit in mice
Authors: Dürsteler Christian , Mases Anna , Fernandez Victor , Pol Olga , Puig Margarita M. 
Published: November 2005

AbstractBackground Clinical studies suggest that tramadol‐induced analgesia is partially antagonized by ondansetron.Aims To investigate the type of interaction between tramadol and two anti‐emetics on antinociception and gastrointestinal transit in mice.Methods We assessed the antinociceptive (acetic acid writhing test, plantar test) and antitransit (charcoal meal) effects of tramadol individually, and combined with ondansetron or droperidol in female Swiss CD‐1 mice. Isobolograms and analysis of variance were used to determine the type of interaction.Results In the writhing test, tramadol, ondansetron and droperidol, each induced dose‐related inhibition of nociception. The ED50's were: tramadol 4.2 ± 0.33 mg kg−1; ondansetron 1.03 ± 0.05 mg kg−1, and droperidol 1.00 ± 0.14 mg kg−1. Dose‐response curves were also obtained with tramadol combined with ondansetron or droperidol at 1:1 fixed ratios. The isobolographic analysis demonstrated antagonism for both combinations.In the plantar test, the ED50 for tramadol was 51.4 ± 2.3 mg kg−1, but no dose‐response curves could be obtained with ondansetron or droperidol individually. The interaction was assessed from dose‐response curves to tramadol in the presence of a fixed dose of ondansetron (0.1 mg kg−1) or droperidol (0.05 mg kg−1). The results show antagonism between tramadol—ondansetron (p < 0.05) and no interaction for the tramadol—droperidol combination. Both anti‐emetics antagonized the antitransit effects of tramadol.Conclusions The interaction of tramadol with ondansetron or droperidol on antinociception can be antagonistic or additive, depending on the type of stimuli. Both anti‐emetics antagonize the anti‐transit effects of tramadol. The results demonstrate antagonism between tramadol and the two anti‐emetics for analgesia and inhibition of gastrointestinal transit, supporting previous clinical studies.
Impairments as measured by ISS do not greatly change between one and eight years after CRPS 1 diagnosis
Authors: Vaneker Michiel , Wilder‐Smith Oliver H.G. , Schrombges Patrick , Oerlemans H. Margreet 
Published: November 2005

AbstractBackground Complex Regional Pain Syndrome type 1 (CRPS 1) is a potentially incapacitating complication in which pain seems to be the most disabling factor. We performed a late follow up study of a well‐defined CRPS 1 population more than eight years after diagnosis. The relationships between early and late impairments were studied with a view to outcome prediction and to investigate possible differences in long‐term impairments according to initial CRPS 1 subdiagnosis (i.e. “warm” or “cold”, diagnosed according to skin temperature measured via infrared thermometer).Methods We again measured patients using the Impairment Level SumScore (ISS) (T8). These data were compared with earlier ISS measurements at CRPS diagnosis (T0) and after one year's treatment (T1). Correlations were determined between these measures.Results Forty‐five patients participated in the present study. Total median ISS improved by 55% (statistically/clinically significant) after one year's treatment (T1), and worsened (non‐significantly) by 14% from T1 to T8 — without differences according to original subdiagnosis. ISS correlations were stronger for T1 vs. T8 than for T0 vs. T1 or T0 vs. T8, being strongest for the ISS factors related to pain.Conclusions Considerable impairments, as measured by ISS, are still present over eight years after first CRPS 1 diagnosis. These do not greatly change between one and eight years post‐diagnosis. ISS outcomes are similar for “cold” and “warm” CRPS 1 diagnostic subgroups. Component ISS scores associated with pain appear to possess greatest predictive power.
Psychometric evaluation of multidimensional pain inventory (Swedish version) in a sample of elderly people
Authors: Jakobsson Ulf , Horstmann Vibeke 
Published: November 2005

AbstractObjectives The aim was to psychometrically evaluate the Swedish version of the Multidimensional Pain Inventory (MPI‐S) and the “brief screening version of MPI‐S” for use in an elderly sample.Methods This study comprised 175 people aged 76–99 years reporting pain and in need of help to manage daily living. The instrument's factor structures were investigated through factor analyses, convergent and discriminant validity were assessed through inter‐scale correlations and correlations with items from SF‐12. Reliability was assessed by Cronbach's alpha.Results The full‐length version of MPI‐S did not, in general, show any satisfactory validity and reliability when used among elderly. It had acceptable convergent and discriminant validity, but the factor analysis did not show a good model fit. Low α values were found for most of the sub‐scales. However, the brief screening version of MPI showed acceptable validity and reliability, except for rather low α values in sections 3 and 4.Conclusion The MPI‐S instrument may not be very useful for measuring pain among frail elderly. The brief screening version may instead be a better alternative to the full version of the MPI‐S. However, the small number of observations may be the reason to the lack of fit, and further studies are warranted.
Conventional and color Doppler sonography in preoperative assessment of ovarian tumors
Authors: Tempe A. , Singh S. , Wadhwa L. , Garg A. 
Published: November 2005

AbstractObjective: To study the vascular patterns of ovarian tumors by color Doppler imaging (CDI) and compare the findings of conventional sonographic studies and CDI with histopathologic findings for the same tumors. Methods: Fifty nonpregnant women scheduled for elective surgery for ovarian tumors were examined by sonographic scanning and CDI by the same physician. Sonographic morphology scores [SMSs] were used, and the pulsatility index (PI) and resistance index (RI) were calculated after locating vessels in and around the tumors by CDI. Results: It was possible to obtain CDI results in 26 of the 50 women. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were 100%, 71.43%, 73.33%, and 100%, respectively, for SMS. With CDI, the sensitivity, specificity, PPV, and NPV were 100%, 85.72%, 95%, and 100% for PI and 100%, 71.43%, 90.48%, and 100% for RI. RI sensitivity and specificity were identical to those of SMS, i.e., 100% and 71.43%, respectively, but PI specificity was better (85.72%). Conclusion: In this study, CDI was definitely better than SMS when color flow could be obtained through the tumors. The overall efficiency in diagnosing the nature of tumors is very high if SMS and CDI are both used in patients having ovarian tumors.
Implications of the activational cleavage of PAR1 by MMP-1 in human breast cancer
Authors: Mercuri Francesca A. , Thompson Erik W. 
Published: November 2005

Citation of original article:A. Boire, L. Covic, A. Agarwal, S. Jacques, S. Sherifi, A. Kuliopulos. PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells.Cell2005;120(3): 303–13.Abstract of the original articleProtease-activated receptors (PARs) are a unique class of G protein-coupled receptors that play critical roles in thrombosis, inflammation, and vascular biology. PAR1 is proposed to be involved in the invasive and metastatic processes of various cancers. However, the protease responsible for activating the proinvasive functions of PAR1 remains to be identified. Here, we show that expression of PAR1 is both required and sufficient to promote growth and invasion of breast carcinoma cells in a xenograft model. Further, we show that the matrix metalloprotease, MMP-1, functions as a protease agonist of PAR1 cleaving the receptor at the proper site to generate PAR1-dependent Ca2+signals and migration. MMP-1 activity is derived from fibroblasts and is absent from the breast cancer cells. These results demonstrate that MMP-1 in the stromal-tumor microenvironment can alter the behavior of cancer cells through PAR1 to promote cell migration and invasion.
Review of: Are breast density and bone mineral density independent risk factors for breast cancer?
Authors: Hopper J. L. 
Published: November 2005

Citation of original article:K. Kerlikowske, J. Shepherd, J. Creasman, J. A. Tice, E. Ziv, S. R. Cummings. Are breast density and bone mineral density independent risk factors for breast cancer. Journal of the National Cancer Institute 2005; 97(7): 368–74.Abstract of the original articleBackground: Mammographic breast density and bone mineral density (BMD) are markers of cumulative exposure to estrogen. Previous studies have suggested that women with high mammographic breast density or high BMD are at increased risk of breast cancer. We determined whether mammographic breast density and BMD of the hip and spine are correlated and independently associated with breast cancer risk. Methods: We conducted a cross-sectional study (N = 15 254) and a nested case-control study (of 208 women with breast cancer and 436 control subjects) among women aged 28 years or older who had a screening mammography examination and hip BMD measurement within 2 years. Breast density for 3105 of the women was classified using the American College of Radiology Breast Imaging Reporting and Data System (BI-RADS) categories, and percentage mammographic breast density among the case patients and control subjects was quantified with a computer-based threshold method. Spearman rank partial correlation coefficient and Pearson's correlation coefficient were used to examine correlations between BI-RADS breast density and BMD and between percentage mammographic breast density and BMD, respectively, in women without breast cancer. Logistic regression was used to examine the association of breast cancer with percentage mammographic breast density and BMD. All statistical tests were two-sided. Results: Neither BI-RADS breast density nor percentage breast density was correlated with hip or spine BMD (correlation coefficient = −.02 and −.01 for BI-RADS, respectively, and −2.06 and .01 for percentage breast density, respectively). Neither hip BMD nor spine BMD had a statistically significant relationship with breast cancer risk. Women with breast density in the highest sextile had an approximately threefold increased risk of breast cancer compared with women in the lowest sextile (odds ratio: 2.7; 95% confidence interval: 1.4–5.4); adjusting for hip or spine BMD did not change the association between breast density and breast cancer risk. Conclusion: Breast density is strongly associated with increased risk of breast cancer, even after taking into account reproductive and hormonal risk factors, whereas BMD, although a possible marker of lifetime exposure to estrogen, is not. Thus, a component of breast density that is independent of estrogen-mediated effects may contribute to breast cancer risk.
Long‐chain polyunsaturated fatty acids in Chinese and Swedish mothers: Diet, breast milk and infant growth
Authors: XIANG MINGYAN , HARBIGE LAURENCE S. , ZETTERSTRÖM ROLF 
Published: November 2005

AbstractLong‐chain polyunsaturated fatty acids (LC‐PUFAs) are essential dietary nutrients required for the optimal growth and development of infants, particularly of the brain and retina. It is important for exclusively breastfed infants to receive milk of a correct balance between ω‐6 and ω‐3 fatty acids. In this study, we compared the composition of LC‐PUFAs in the diet and milk of mothers and their infants' growth between Chinese and Swedish. Twenty‐three and 19 mother‐term infant pairs from a rural area of northern Beijing, China, and Stockholm, Sweden, who were 3 mo old and exclusively breastfed, were studied. The Chinese diet was higher in carbohydrate (17% of energy) but lower in protein (4% of energy) and fat (12% of energy) than the Swedish diet. The intake of Chinese mothers contained more linoleic acid (LA, C18:2 ω‐6) and less arachidonic acid (AA, C20.4 ω‐6), eicosapentaenoic acid (EPA, C20:5 ω‐3) and docosahexaenoic acid (DHA, C22:6 ω‐3) than that of Swedish mothers. The breast milk of the Chinese mothers had significantly higher LA and lower EPA and DHA levels than that of the Swedish mothers. However, in Chinese breast milk the AA level was significantly higher than that in Swedish breast milk. The recommended ranges of the ratios of LA to α‐linolenic acid (LNA, C18:3 ω‐3) and of AA to DHA in human milk are 5–10 and 0.5–1 compared with 23.0 and 3.1 in the Chinese breast milk, and 7.5 and 1.6 in the Swedish breast milk, respectively.Conclusion: The diet of the studied Chinese mothers is less balanced with regard to the levels of ω‐6 and ω‐3 polyunsaturated fatty acids (PUFAs) than that of the Swedish mothers, which is also mirrored in the breast milk of these mothers. The clinical relevance of the difference between the levels of LC‐PUFAs in the breast milk of Chinese and Swedish mothers may be elucidated by a follow‐up study of the cognitive and visual functions of the infants involved.
Anthropometry at the time of diagnosis in Danish children with inflammatory bowel disease
Authors: PAERREGAARD ANDERS , URNE FREDERIKKE ULDALL 
Published: November 2005

AbstractAll patients below 15 y of age living in the eastern part of Denmark with a diagnosis of inflammatory bowel disease (IBD) during the period 1998–2000 were identified (n = 94) and anthropometrical data at the time of diagnosis were evaluated.Conclusion: The height‐for‐age and the BMI‐for‐age, as evaluated by z‐scores, of children with ulcerative colitis (UC) did not differ from those of normal Danish children, but Crohn's disease (CD) children had significantly lower height and BMI values, both when compared to normal children and children with UC. In contrast to UC, CD is frequently complicated by malnutrition and growth retardation at the time of diagnosis.
Doxapram and developmental delay at 12 months in children born extremely preterm
Authors: LANDO ANE , KLAMER ANJA , JONSBO FINN , WEISS J ANNE , GREISEN GORM 
Published: November 2005

AbstractAim: To examine the relation of doxapram to a developmental score achieved by a structured telephone interview in a group of extremely‐preterm‐born children.Methods: Parents of 88 children born extremely preterm were contacted by telephone and interviewed by a structured questionnaire (R‐PDQ) when the corrected age of their child was 9–15 mo.Results: We found that doxapram treatment was associated with a deficit in age‐adjusted R‐PDQ score.Conclusion: Doxapram may have a negative effect on neurodevelopmental outcome.
The effect of voluntary dehydration on cognitive functions of elementary school children
Authors: BAR‐DAVID YAIR , URKIN JACOB , KOZMINSKY ELY 
Published: November 2005

AbstractAims: (1) To describe the occurrence of voluntary dehydration in two classes of elementary school students as expressed by their morning and noon‐time urine osmolality; and (2) to determine the relationship between the children's scores on cognitive tests and their state of hydration.Methods: Group comparison among fifty‐eight sixth‐grade students (age range 10.1–12.4 y old) during mid‐June at two schools in a desert town. Morning and noon‐time urine samples were collected in school, and five cognitive tests were scored in the morning and at noon‐time. Main outcome measures: (1) morning and noon‐time urine osmolality; (2) scores of five cognitive tests (hidden figures, auditory number span, making groups, verbal analogies, and number addition) that were applied in the morning and at noon‐time.Results: Thirty‐two students were dehydrated (urine osmolality above 800 mosm/kg H2O) in the morning. An individual's noon‐time urine osmolality was highly related to morning osmolality (r = 0.67, p = 0.000). The morning cognitive scores were similar in the hydrated and dehydrated students (p = 0.443). The adjusted mean scores of the noon‐time tests, with the morning test scores as covariates, demonstrated an overall positive trend in four of the five tests in favor of the hydrated group (p = 0.025). The effect was mainly due to the auditory number span test (p = 0.024).Conclusion: Voluntary dehydration is a common phenomenon in school‐aged children that adversely affects cognitive functions.
A decreasing rate of neural tube defects following the recommendations for periconceptional folic acid supplementation
Authors: KLUSMANN ANNE , HEINRICH BEATE , STÖPLER HEIKE , GÄRTNER JUTTA , MAYATEPEK ERTAN , VON KRIES RÜDIGER 
Published: November 2005

AbstractBackground/aim: Neural tube defects (NTDs) are the most common birth defects, resulting in severe mortality and morbidity. In 1995, the supplementation of folic acid periconceptionally was officially recommended in Germany. The impact of the recommendations on the rate of NTDs was assessed.Methods: An active surveillance system was established in the northern Rhine area. From 1996, all departments of obstetrics were asked to report cases of NTDs in all abortions, live births and stillbirths. Compliance with the recommendations was evaluated in a sample of mothers who delivered at the Department of Obstetrics of Düsseldorf University in 2001.Results: From 1996–2003, 520 NTDs were reported. Compared to the rate of NTDs in 1996 (10.5/10000), the average incidence in the years 1997 to 2003 dropped (6.8/10000). The intake of folic acid, as recommended, was low among the general population (21.1%).Conclusion: Active surveillance data on the rate of NTDs are compatible with the maximum decrease of about 20% to be expected from data on the implementation of the recommendations. A much greater decrease in NTDs should be the challenge for the future.
Perinatal management of a preterm neonate affected by hyperprostaglandin E2 syndrome (HPS)
Authors: KÖMHOFF MARTIN , TEKESIN ISMAIL , PETERS MELANIE , LEONHARD ANDREAS , SEYBERTH HANNSJÖRG W. 
Published: November 2005

AbstractBackground: Neonates affected by hyperprostaglandin E2 syndrome (HPS) present with severe polyuria. Both urinary losses as well as prostaglandin synthesis inhibitors may precipitate acute renal failure (ARF). Aim: Our goal was to maintain euvolaemia by replacement of urinary losses. Patient: Our patient was born prematurely with a family history typical of HPS. Urinary salt and water losses and PGE2 excretion were determined in 2‐ to 4‐h intervals. Salt and water were replaced accordingly.Results: Within the first 48 h, urinary losses and PGE2 increased continuously to 50 ml/kg/h and 374 ng/h/1.73 m2, respectively. Following exposure to 0.05–0.5 mg/kg/d indomethacin, urinary output decreased steadily to 10–15/ ml/kg/h.Conclusion: In euvolaemic preterm neonates with HPS and the need for excessive replacement of salt and water, inhibition of renal PGE2 excretion with indomethacin effectively reduces polyuria and natriuresis without acutely compromising renal function.