bluuebunny/crossref_metadata_2025_split huggingface dataset:
AN UNUSUAL EPITHELIAL‐CONNECTIVE TISSUE NAEVUS WITH PERIFOLLICULAR MUCINOSIS*
Authors: Becke R. F. A. , Musso L. A. 
Published: June 2007

SummaryTwo pigmented lesions (one on each cheek of an adolescent boy) have been examined histologically on two occasions at an interval of eighteen months. The lesions had appeared following exposure to strong sunlight. Epithelial thickening with increased pigmentation, perifollicular mucin, absence of sebaceous glands and increased elastic tissue were found. Some comments are offered to explain these changes. It appears that the lesions are of naevoid origin.
RETICULAR ERYTHEMATOUS MUCINOSIS (REM SYNDROME) OF STEIGLEDER: ITS RELATIONSHIP TO OTHER MUCINOSES AND TO CHRONIC ERYTHEMATA*
Authors: Kocsard E. , Munro V. F. 
Published: June 2007

SummaryThe reticular erythematous mucinosis syndrome of Steigleder is a macular erythema‐tous form of inflammatory mucinosis. Clinically and histopathologically it has many similarities with the plaque‐like mucinosis of Perry. Transitional forms between the two conditions exist. The histopathological picture of the syndromes is not diagnostic and is indistringuishable from that of the lymphocytic infiltration of the skin described by Jessner and Kanof and from some of the chronic inflammatory dermatoses. The clinical picture in combination with the histopathological changes is, however, sufficiently characteristic to define the mucinosis of Steigleder and Perry as a clinical entity.
MYCETOMA CAUSED BY MADURELLA MYCETOMII IN MADRAS
Authors: Taralakshmi V. V. , Pankajalakshmi V. V. , Arumugam S. , Subramanian S. 
Published: June 2007

SummaryBiopsy specimens of 102 patients with mycetoma were examined histologically and Madurella mycetomii was found in 29 cases. Four cases of mycetoma pedis and a single case of mycetoma of the hand from which M. mycetomii has been isolated in culture are described. In all cases, the characteristic black granules were seen.The geographic distribution of the organism and its incidence and prevalence in India are discussed.
LANGERHANS CELL AND MELANOCYTE DISTRIBUTION IN “NORMAL” HUMAN EPIDERMIS
Authors: Scheibner A. , McCarthy W. H. , Milton G. W. , Nordlund J. J. 
Published: June 2007

SummaryLangerhans cells and melanocyte distribution was determined in 18 different body sites in 76 cadavers, 44 men and 32 women, within 24 hours of death. The Langerhans cell and melanocyte counts were inversely related so that in sun‐exposed (tanned) epidermis Langerhans cell numbers were lower and melanocyte numbers were higher than in non‐exposed (non‐tanned) epidermis. Langerhans cell and melanocyte densities were similar in men and women on non‐exposed (non‐tanned) epidermis when matched by age. In any one subject Langerhans cell densities were even throughout the body except on sun‐exposed (tanned) areas, where Langerhans cell counts were not only significantly lower but the cells were also unevenly distributed. Langerhans cell counts for all body areas decreased with age in both men and women.
SHOE DERMATITIS*
Authors: Freeman Susanne 
Published: June 2007

SummaryFoot dermatitis can be an extremely disabling problem. Blistering and weeping feet may become secondarily infected and painful fissuring often occurs, resulting in inability to walk. The diagnosis of contact dermatitis due to shoes should be considered in every case of persistent foot dermatitis. It is only by careful patch testing that this diagnosis can be made. The so‐called typical clinical pattern of shoe contact dermatitis is often not present. A shoe contact dermatitis can be superimposed on an endogenous foot dermatitis.
“BLACK SPOTS” IN PAPUA NEW GUINEA DEFENCE FORCE PERSONNEL: REPORT OF 12 CASES*
Authors: Talwat E. N. 
Published: June 2007

SummaryA fixed drug eruption related to the ingestion of Maloprim is described in Papua New Guinea Defence Force members and their dependants. Provocation tests using the two constituents of Maloprim indicated that dapsone was the cause. A fixed drug eruption caused by dapsone was reported in 1964 in deeply pigmented leprosy patients in Africa. This eruption has not been reported in Papua New Guinean leprosy patients on dapsone therapy.
THE PREVALENCE AND ACCURACY OF DIAGNOSIS OF NON‐MELANOTIC SKIN CANCER IN VICTORIA*
Authors: Ponsford M. W. , Goodman G. , Marks R. 
Published: June 2007

SummarySurveys of Victorian dermatologists and pathologists were undertaken to determine the number of patients attending medical practitioners with non‐melanotic skin cancers and solar keratoses. Results suggest that at least 1,000 patients per week are attending for diagnosis and treatment.Accuracy of clinical diagnosis studies suggest that the correct diagnosis of these tumours isbeing made clinically in approximately 70% of cases by experienced clinicians. It is suggested that histology be obtained in all lesions in which a clinical diagnosis of skin cancer is considered. The incidence of squamous cell carcinoma compared to that of basal cell carcinoma is seen to rise where histological examination is performed.
CLINICO‐HISTOPATHOLOGICAL STUDY OF EPIDERMAL NAEVI
Authors: Submoke S. , Piamphongsant T. 
Published: June 2007

SummaryThe clinical and histopathological features of epidermal naevi from 75 patients were reviewed. In approximately two‐thirds of the patients, these lesions were not present at birth. Five classical clinical varieties and ten histopathological patterns were observed. It was only possible to determine the types of histopathological patterns by the examination of the clinical features alone in the cases of linear porokeratosis and linear naevus comedonicus. A further clinical type of inflammatory linear verrucous epidermal naevus was revealed in this study. This consisted of asymptomatic short linear brownish plaques in which the lesions did not resemble the classical itching linear erythematous plaques.
DISORDERED CYCLIC NUCLEOTIDE METABOLISM–A BASIC DEFECT IN ATOPIC DERMATITIS*
Authors: Butler James M. 
Published: June 2007

SUMMARYDysfunction in a wide variety of cellular immune mechanisms occurs in atopic dermatitis and contributes to the clinical presentation of the condition.The increased incidence of cutaneous viral and fungal infections, observed clinically in atopic dermatitis, suggests altered T‐lymphocyte function and elevated serum IgE levels suggest deregulation of B‐lymphocyte function. The clinical features of pruritus and erythema raise the possibility of increased release of inflammatory mediators into the circulation. In vitro studies have confirmed abnormalities in T‐lymphocyte subset numbers and function as well as increased releasability of histamine from blood basophils in atopic dermatitis.Recent studies have revealed abnormalities in the metabolism of cyclic AMP, an important mediator in cellular regulatory mechanisms, in atopic dermatitis. Leucocyte cyclic AMP responses to a variety of agonists are blunted in atopic dermatitis and are due, at least in part, to increased cyclic AMP phosphodiesterase activity. It is unclear at present whether this enzyme abnormality is genetically determined or whether it is induced by increased circulating levels of inflammatory mediators. A number of the in vitro abnormalities in atopic dermatitis appear to correlate with the increase in phosphodiesterase activity.Further research aimed at finding ways to inhibit phosphodiesterase activity in atopic dermatitis and consequently reversing other abnormalities in cellular function, will hopefully open up new avenues of therapy for this common and disabling condition.
PHOTOCONTACT ALLERGY TO OCTYLDIMETHYL PABA
Authors: Weller Paul , Freeman Susanne 
Published: June 2007

SummaryA case of photocontact allergy to a sunscreen product containing octyldimethyl paraaminobenzoic acid (O‐PABA) with cross sensitivity to isobutyl PABA is presented. A discussion of sunscreen products follows, including the properties of the active ingredients and the vehicles. A list of commercial products grouped according to sunscreen type follows.
A CASE OF MYCOSIS FUNGOIDES TREATED WITH ETRETINATE
Authors: Wargon Orli , Downie David 
Published: June 2007

SummaryA 64 year old man with refractory stage II cutaneous T‐cell lymphoma was treated with etretinate (RO109359) at 2 mg/kg/day with near clearing of nodules, plaques and pruritus in eight weeks. There were minimal side effects and no flare of his disease in five months on maintenance treatment with etretinate 1 mg/kg/day.
ERYTHEMA MULTIFORME: EPIDEMIOLOGY, CLINICAL CHARACTERISTICS AND NATURAL HISTORY IN FIFTY‐NINE PATIENTS
Authors: Ting H. C. , Adam B. A. 
Published: June 2007

SummaryIn this paper we report fifty‐nine patients with erythema multiforme. Thirty‐four of the patients were classified as erythema multiforme major (EM major) or Stevens‐ Johnson syndrome and the other twenty‐five erythema multiforme minor (EM minor). The overall features of this group of fifty‐nine patients are discussed and the significant differences between the two sub‐groups (EM major and EM minor) highlighted.
UNUSUAL SKIN MANIFESTATIONS OF DRUG PHOTOSENSITIVITY
Authors: Burry John N. 
Published: June 2007

SummaryPhotosensitivity from drugs does not always present in a classical fashion involving all areas of exposure. The area of involved skin may be limited and cause confusion in diagnosis. Drug photosensitivity causes both transient and persistent light reactions. The cases described in this paper illustrate in a clinical fashion, the manner in which the diagnosis of drug eruptions can be complicated in our daily clinical work.
FACIAL GRANULOMA
Authors: Frost Felicity A. , Heenan Peter J. 
Published: June 2007

SummaryThe clinical and pathological features of six patients with facial granuloma are presented. Of a total of 11 lesions biopsied, only one was correctly diagnosed clinically, eight other lesions being regarded as basal cell carcinomas. Histological diagnosis was delayed in one patient with multiple and extrafacial lesions, emphasizing the importance of early diagnosis. Facial granuloma should be considered in the differential diagnosis of any mixed inflammatory dermal infiltrate with an eosinophil component occurring in sun‐exposed skin.
ISOLATION OF DERMATOPHILUS CONGOLENSIS FROM TWO NEW ZEALAND CASES OF PITTED KERATOLYSIS
Authors: Woodgyer A. J. , Baxter M. , Rush‐Munro F. M. , Brown J. , Kaplan W. 
Published: June 2007

SUMMARYPitted keratolysis is a skin disease characterized by the appearance of pitted lesions on the pressure‐bearing areas of the soles of the feet and less often affecting the palms of the hands. A coccofilamentous bacterium is consistently seen in microscopic preparations from the lesions and may be the causative agent of the disease. However, there has been some dispute as to the organism's identity because of the isolation of a number of different micro‐organisms, including Streptomyces spp. and a Corynebacterium sp. from previously reported cases. On the basis of histopathological evidence, it has also been suggested that the actinomycete Dermatophilus congolensis might be associated with the condition. In the present study, investigations into the prevalence and laboratory diagnosis of the condition resulted in the isolation of D. congolensis from two cases. The two isolates differed from those usually recovered from cases of dermatophilosis in humans and animals and may represent a hitherto unrecognized biotype of the species.
SUBUNGUAL MALIGNANT MELANOMA: A DISEASE ENTITY SEPARATE FROM OTHER FORMS OF CUTANEOUS MELANOMA
Authors: Milton G. W. , Shaw H. M. , McCarthy W. H. 
Published: June 2007

SUMMARYThe characteristics and results of treatment of 30 patients with subungual malignant melanoma treated at the Sydney Melanoma Unit were studied. It was found that in several major respects subungual melanoma differed from other forms of cutaneous melanoma. Patients with subungual melanoma were considerably older than those with either superficial spreading or nodular melanoma and there was a preponderance of men with subungual melanoma of the upper extremity. Independent prognostic factors (such as tumour thickness) which are important in determining survival in patients with superficial spreading or nodular melanoma, had little consequence in patients with subungual melanoma. Despite the fact that the vast majority of subungual melanomas were very thick and ulcerated due to the delay in correctly diagnosing the disease clinically, overall survival rate was reasonably good, providing patients had an amputation of the entire digit together with either a prophylactic or therapeutic lymph node dissection. These findings indicate that subungual melanoma is a disease entity separate from other forms of cutaneous melanoma and that radical surgery is essential in all subungual melanoma patients.
CEMENT BURNS: RARE OR RARELY REPORTED?
Authors: Fischer Gayle , Commens Chris 
Published: June 2007

SummaryProlonged contact with ready mixed cement is a rare cause of severe chemical burns. A 15 year old boy required debridement and skin grafting to a burn on his knee caused by contact with cement. Asa result he lost five weeks from school. We discuss the factors that predispose to this unusual event and pose the question as to why we hear of it so infrequently.
EPIDERMOLYSIS BULLOSA—A NEW SUBGROUP
Authors: Eisenberg M. , Shorey C. D. , de Chair‐Baker W. 
Published: June 2007

SummaryA patient aged 16 years with a new mechanobullous disease is described. He had suffered from trauma‐induced bullae since birth. The lesions increased in hot weather and healed without scarring. The clinical picture was suggestive of Weber‐Cockayne or a mild Köbner type of epidermolysis bullosa simplex. Ultrastructural investigation of afresh blister revealed intraepidermal blister formation via cytolysis of basal cell cytoplasm at or above the hemidesmosomes to which were attached clumps of tonofilaments. On the floor of the blister the basal lamina and anchoring fibrils were normal. This type of blister morphology is characteristic of epidermolysis bullosa herpetiformis of Dowling‐Meara so that this patient has either a mild atypical form of the above disease or his case represents an example of a new subgroup of epidermolysis bullosa produced by a spontaneous allelic mutation.
DAPSONE AND SULFAPYRIDINE THERAPY OF PEMPHIGOID DISEASES
Authors: Rogers Roy S. 
Published: June 2007

SummarySince 1974, dapsone and sulfapyridine have been used to treat 30 patients with localized oral pemphigoid, 36 with cicatricial pemphigoid, and 11 with cicatricial pemphigoid limited to the eyes; 7 of these 77 patients were less than 50 years of age. Follow‐up was J to 12 years (mean, 4.8 years). Of the 30 patients with localized oral pemphigoid, half were in remission and off treatment at a mean follow‐up of 5 years. Of 25 patients with cicatricial pemphigoid who received dapsone therapy as initial treatment, 15 (60%) had a successful result. Sulfapyridine was successful in three patients and dapsone in six additional patients after other therapy. Thus, dapsone or sulfapyridine therapy was successful in 24 of 34 patients (71%). In 30 patients with pemphigoid limited to the ocular mueosa or cicatricial pemphigoid with ocular manifestations, 25 (83%) responded successfully to dapsone or sulfapyridine; there were no treatment failures among these 30 patients with ocular pemphigoid. Overall, of the 77 patients, of 55 who underwent an evaluable eotirse of dapsone or sulfapyridine therapy, 47 (85%) responded successfully.
HYPERTROPHIC LUPUS ERYTHEMATOSUS: DIFFERENTIATION FROM SQUAMOUS CELL CARCINOMA
Authors: Vinciullo Carl 
Published: June 2007

SummaryHypertrophic lupus erythematosus (HLE) may be more common as a variant of discoid lupus erythematosus (DLE) than is reported in the literature. Differentiation from neoplastic transformation of a lesion of DLE to squamous cell carcinoma (SCC) is crucial because of the metastatic potential of this type of SCC. A man is described in whom hypertrophic lesions of LE accompanying lesions of classic DLE were interpreted histopathologically as SCC. The problem of differentiating true HLE from SCC arising within DLE is discussed with a review of the relevant literature.
HYPERTRICHOSIS LANUGINOSA ACQUISITA AND ADENOCARCINOMA OF THE COLON
Authors: Dyall‐Smith Delwyn , Varigos George , Thomas Robert 
Published: June 2007

SummaryWe report the case of a 48 year old man who developed hypertrichosis lanuginosa acquisita in association with adenocarcinoma of the colon. All laboratory investigations were normal. We present a literature review of this rare but important paraneoplastic sign which is most commonly associated with malignancies of the gastrointestinal tract.
TREATMENT OF PSEUDALLESCHERIA BOYDII INFECTION WITH ORAL KETOCONAZOLE AND TOPICAL MICONAZOLE
Authors: Willsteed Elizabeth , Regan William 
Published: June 2007

Summary Skin infection in a man immunosuppressed by corticosteroid treatment was found to be due to Pseudallescheria boydii. Although treatment is often unsatisfactory, infection in this patient responded well to oral ketoconazole and topical miconazole.
KERATITIS, ICHTHYOSIS AND DEAFNESS (KID SYNDROME)
Authors: Singh Kamlender 
Published: June 2007

SummaryA boy with ichthyosiform erythroderma also suffered from sensorineural deafness, superficial punctate keratitis and acanthosis nigricans. Histopathology revealed basket weave hyperkeratosis, hydropic degeneration of the basal layer, melanin incontinence and moderate mononuclear infiltrate. Typical histological changes were found in clinical lesions of acanthosis nigricans.
BENIGN CEPHALIC HISTIOCYTOSIS
Authors: Commens Chris , Jaworski Richard 
Published: June 2007

SummaryA 3 year old boy had an asymptomatic pigmented maculopapular eruption on his face for 2½ years. This rash partially resolved in summer and remitted in winter. Skin biopsy and ultrastructural studies showed a histiocytic infiltrate with “comma shaped” cytoplasmic inclusions, confirming the diagnosis of Benign Cephalic Histiocytosis. We review the features of this condition and compare it with other self healing histiocytotic conditions.
TRICHOTHIODYSTROPHY – BIOCHEMICAL AND CLINICAL STUDIES
Authors: Gillespie J. Morton , Marshall Robert C. , Rogers Maureen 
Published: June 2007

SummaryWe are reporting the clinical examination of two children with abnormal hair together with a microscopic and biochemical examination of their hairs. A diagnosis of trichothiodystrophy (TTD) is suggested since both hair samples are cystine‐deficient and contain abnormal patterns of amino acids and proteins. The cystine deficiency was found to be due to a reduction in the amount and cystine content of the high‐sulphur (HS)* protein fraction. An electrophoretic study of the two samples of HS protein gave patterns which differed in a major way from the pattern of a normal HS fraction with the loss of most normal components including the ultra‐high‐sulphur fraction. The pattern of spots of the two abnormal HS proteins not only differed from the normal but from each other and from a third sample of protein from a previously studied TTD hair. It is suggested that this may provisionally support the concept of heterogeneity of TTD.
ONSET OF PSORIASIS COINCIDENT WITH TETRACYCLINE THERAPY
Authors: Tsankov Nikolai K. , Vassileva Snejina V. , Lazarova Aneta Z. , Berowa and Newena V. , Botev‐Zlatov Nikola 
Published: June 2007

SummaryPsoriasis developing after treatment with tetracyclines in a 40 year old female is described with exacerbation after re‐exposure to Doxycycline. The authors emphasize the need for further observations on the influence of antibiotics and especially the tetracycline group on the course of psoriasis.
PUVA THERAPY OF CHRONIC ACTINIC DERMATITIS
Authors: Sinclair Susan E. , Hindson Colin 
Published: June 2007

SummaryA modified PUVA regime was used to treat five men with long‐standing chronic actinic dermatitis. They are all now symptom free on monthly maintenance PUVA therapy and no longer react abnormally to ultra‐violet radiation, with consequent improvement of their quality of life.
SPIRONOLACTONE THERAPY IN HIRSUTISM AND ACNE
Authors: Callan Annette W. 
Published: June 2007

SummarySpironolactone has been found to have anti‐androgenic properties and to be useful in the treatment of female hirsulism. Benefits have also been noted in the treatment of mature age onset or persistent acne in females. The mechanism of action of this drug is mainly via a peripheral anti‐androgenic effect but it may also result in decreased androgen production. The results of a number of clinical studies are discussed with particular reference to the side effects of spironolactone. Guidelines for treatment of hirsutism and female mature age acne are given.
HUMAN PAPILLOMA VIRUS INDUCED EPIDERMAL PROLIFERATIONS OF THE ANOGENITAL REGION
Authors: Heenan Peter J. 
Published: June 2007

SUMMARYCondyloma acuminatum and bowenoid papulosis are squamous ceil papillomas of the anogenital region probably induced by human papillomavirus of different types. Although both lesions appear to be essentially benign, both have been linked by clinical, virological and epidemiological evidence with the development of anogenital cancer, thus making their precise identification more important than consideration of their purely local effects would indicate. Bowenoid papulosis presents diagnostic problems, particularly in its distinction from Bowen's disease, but the clinical and histological features considered together make a characteristic presentation.
SWEET'S SYNDROME ASSOCIATED WITH ADENOCARCINOMA OF THE PROSTATE
Authors: Dyall‐Smith Delwyn , Billson Virginia 
Published: June 2007

SUMMARYSweet's syndrome can occur in association with malignancy, in particular acute myeloid leukaemia. It has rarely reported with solid tumours. A case of recurrent Sweet's syndrome in a 75 year old man with metastatic prostatic carcinoma is presented.
TREATMENT OF ALOPECIA AREATA WITH DIPHENCYPRONE
Authors: Hatzis J. , Georgiotouo K. , Kostakis P. , Anastasiadis G. , Tosca A. , Varelzidis A. , Straigos J. 
Published: June 2007

SUMMARYForty‐five patients with extensive alopecia areata were treated by local application of diphencyprone. Only eleven had satisfactory regrowth of hair. Six had moderate regrowth, and of the remaining 28 some showed regrowth of vellus hair and others had no response. The side effects of the treatment consisted of intense allergic or irritant reactions, febrile reactions, anaphylactic reaction with fainting, and vitiligo. In twelve patients progressive desensitisation was observed. As the effectiveness of this treatment is low and side effects are common and sometimes severe, we conclude that diphencyprone has no advantage in the treatment of alopecia areata.
DRUG ERUPTIONS WITH LICHENOID HISTOLOGY PRODUCED BY CAPTOPRIL
Authors: Rotstein Eva , Rotstein Harvey 
Published: June 2007

SummaryThree cases are presented with a rash due to captopril which, on histology, showed a lichenoid pattern of bandlike upper dermal infiltrate of lymphocytes and histiocytes, together with hydropic degeneration of the basal layer of the epidermis producing Civatte bodies and pigmentary incontinence.The rash presented either as a pityriasis rosea‐like picture which appeared about three to six months after the onset of treatment in patients taking tow doses, or alternatively, as lichenoid plaques which appeared three to six months after commencement of medication in patients taking high doses.Although both clinical patterns produced a “saw tooth” pattern of the epidermal rete ridges, hypergranulosis and acanthosis were seen only with the lichenoid plaques.
LICHEN NITIDUS CONFINED TO ONE PALM
Authors: Bear Colin L. , Willsteed Elizabeth M. , Zagarella Samuel S. 
Published: June 2007

SummaryLichen nitidus is an unusual dermatosis which tends to involve the trunk, penis and forearms of children and young adults.1 It is usually bilaterally symmetrical. We report a case of unilateral palmar lichen nitidus in an elderly man.