bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comprehensive mapping of the AOP-Wiki database: identifying biological and disease gaps
Authors: Jaylet Thomas , Coustillet Thibaut , Smith Nicola M. , Viviani Barbara , Lindeman Birgitte , Vergauwen Lucia , Myhre Oddvar , Yarar Nurettin , Gostner Johanna M. , Monfort-Lanzas Pablo , Jornod Florence , Holbech Henrik , Coumoul Xavier , Sarigiannis Dimosthenis A. , Antczak Philipp , Bal-Price Anna , Fritsche Ellen , Kuchovska Eliska , Stratidakis Antonios K. , Barouki Robert , Kim Min Ji , Taboureau Olivier , Wojewodzic Marcin W. , Knapen Dries , Audouze Karine 
Published: March 2024

Introduction: The Adverse Outcome Pathway (AOP) concept facilitates rapid hazard assessment for human health risks. AOPs are constantly evolving, their number is growing, and they are referenced in the AOP-Wiki database, which is supported by the OECD. Here, we present a study that aims at identifying well-defined biological areas, as well as gaps within the AOP-Wiki for future research needs. It does not intend to provide a systematic and comprehensive summary of the available literature on AOPs but summarizes and maps biological knowledge and diseases represented by the already developed AOPs (with OECD endorsed status or under validation).Methods: Knowledge from the AOP-Wiki database were extracted and prepared for analysis using a multi-step procedure. An automatic mapping of the existing information on AOPs (i.e., genes/proteins and diseases) was performed using bioinformatics tools (i.e., overrepresentation analysis using Gene Ontology and DisGeNET), allowing both the classification of AOPs and the development of AOP networks (AOPN).Results: AOPs related to diseases of the genitourinary system, neoplasms and developmental anomalies are the most frequently investigated on the AOP-Wiki. An evaluation of the three priority cases (i.e., immunotoxicity and non-genotoxic carcinogenesis, endocrine and metabolic disruption, and developmental and adult neurotoxicity) of the EU-funded PARC project (Partnership for the Risk Assessment of Chemicals) are presented. These were used to highlight under- and over-represented adverse outcomes and to identify and prioritize gaps for further research.Discussion: These results contribute to a more comprehensive understanding of the adverse effects associated with the molecular events in AOPs, and aid in refining risk assessment for stressors and mitigation strategies. Moreover, the FAIRness (i.e., data which meets principles of findability, accessibility, interoperability, and reusability (FAIR)) of the AOPs appears to be an important consideration for further development.
Phylogenetic and Taxonomic Analyses of Five New Wood-Inhabiting Fungi of Botryobasidium, Coltricia and Coltriciella (Basidiomycota) from China
Authors: Zhou Qian , Jiang Qianquan , Yang Xin , Yang Jiawei , Zhao Changlin , Zhao Jian 
Published: March 2024

In this present study, five new wood-inhabiting fungal taxa, Botryobasidium gossypirubiginosum, Botryobasidium incanum, Botryobasidium yunnanense, Coltricia zixishanensis, and Coltriciella yunnanensis are proposed. Botryobasidium gossypirubiginosum is distinguished by its slightly rubiginous hymenial surface, monomitic hyphal system, which branches at right angles, and subglobose, smooth basidiospores (14–17.5 × 13–15.5 µm); B. incanum is characterized by its white to incanus basidiomata having a hypochnoid hymenial surface, and ellipsoid, smooth basidiospores (6.5–8.5 × 3.5–5 µm); B. yunnanense is characterized by its buff to slightly yellowish hymenial surface, monomitic hyphal system, and broadly ellipsoid to globose, smooth, thick-walled basidiospores (11.5–14.5 × 9.5–10.5 µm); Coltricia zixishanensis differs in its rust brown pileal surface, and ellipsoid, thick-walled basidiospores (5–6.5 × 4–4.5 µm). Coltriciella yunnanensis is distinguished by its tiny pilei, short stipe, and navicular, verrucose basidiospores (10.5–12.5 × 6–7 µm). Sequences of ITS and nLSU genes were used for phylogenetic analyses using the maximum likelihood, maximum parsimony, and Bayesian inference methods. The phylogenetic results inferred from ITS sequences revealed that B. gossypirubiginosum was closely related to B. robustius; the species B. incanum was grouped with B. vagum; B. yunnanense was related to B. indicum. The species C. zixishanensis was grouped with C. confluens and C. perennis. ITS sequences revealed that C. zixishanensis was grouped into the genus Coltriciella, in which it was grouped with Co. globosa and Co. pseudodependens.
An Ultrasoft and Flexible PDMS-Based Balloon-Type Implantable Device for Controlled Drug Delivery
Authors: Muhammad Tausif , Park Byungwook , Intisar Aseer , Kim Minseok S. , Park Jin-Kyu , Kim Sohee 
Published: March 2024

Non-biodegradable implants have undergone extensive investigation as drug delivery devices to enable advanced healthcare toward personalized medicine. However, fibroblast encapsulation is one of the major challenges in all non-biodegradable implants, besides other challenges such as high initial burst, risk of membrane rupture, high onset time, non-conformal contact with tissues, and tissue damage. To tackle such challenges, we propose a novel ultrasoft and flexible balloon-type drug delivery device for unidirectional and long-term controlled release. The ultrasoft balloon-type device (USBD) was fabricated by using selective bonding between 2 polydimethylsiloxane (PDMS) membranes and injecting a fluid into the non-bonded area between them. The balloon acted as a reservoir containing a liquid drug, and at the same time, the membrane of the balloon itself acted as the pathway for release based on diffusion. The release was modulated by tuning the thickness and composition of the PDMS membrane. Regardless of the thickness and composition, all devices exhibited zero-order release behavior. The longest zero-order release and nearly zero-order release were achieved for 30 days and 58 days at a release rate of 1.16 μg/day and 1.68 μg/day, respectively. In vivo evaluation was performed for 35 days in living rats, where the USBD maintained zero-order and nearly zero-order release for 28 days and 35 days, respectively. Thanks to the employment of ultrasoft and flexible membranes and device design, the USBD could achieve minimal tissue damage and foreign body responses. It is expected that the proposed device may provide a novel approach for long-term drug delivery with new therapeutic modalities.
The Inhibition of Fibrosis and Inflammation in Obstructive Kidney Injury via the miR-122-5p/SOX2 Axis Using USC-Exos
Authors: Lu Wenjun , Guo Yujun , Liu Hengchen , Zhang Tingting , Zhang Mingzhao , Li Xiangqi , Li Zhou , Shi Manyu , Jiang Zhitao , Zhao Zheng , Yang Shulong , Li Zhaozhu 
Published: March 2024

Background:Fibrosis and inflammation due to ureteropelvic junction obstruction substantially contributes to poor renal function. Urine-derived stem-cell-derived exosomes (USC-Exos) have therapeutic effects through paracrine.Methods:In vitro, the effects of USC-Exos on the biological functions of HK-2 and human umbilical vein endothelial cells were tested. Cell inflammation and fibrosis were induced by transforming growth factor-β1 and interleukin-1β, and their anti-inflammatory and antifibrotic effects were observed after exogenous addition of USC-Exos. Through high-throughput sequencing of microRNA in USC-Exos, the pathways and key microRNAs were selected. Then, the antifibrotic and anti-inflammatory effects of exosomal miR-122-5p and target genes were verified. The role of the miR-122-5p/SOX2 axis in anti-inflammatory and antifibrotic effects was verified. In vivo, a rabbit model of partial unilateral ureteral obstruction (PUUO) was established. Magnetic resonance imaging recorded the volume of the renal pelvis after modeling, and renal tissue was pathologically analyzed.Results:We examined the role of USC-Exos and their miR-122-5p content in obstructive kidney injury. These Exos exhibit antifibrotic and anti-inflammatory activities. SOX2 is the hub gene in PUUO and negatively related to renal function. We confirmed the binding relationship between miR-122-5p and SOX2. The anti-inflammatory and antifibrotic effects of miR-122-5p were inhibited, indicating that miR-122-5p has anti-inflammatory and antifibrotic effects by inhibiting SOX2 expression. In vivo, the PUUO group showed typical obstructive kidney injury after modeling. After USC-Exo treatment, the shape of the renal pelvis shown a remarkable improvement, and inflammation and fibrosis decreased.Conclusions:We confirmed that miR-122-5p from USC-Exos targeting SOX2 is a new molecular target for postoperative recovery treatment of obstructive kidney injury.
Pengaruh Kompetensi Kewirausahaan Terhadap Keunggulan Bersaing (Studi Pada Industri Kreatif Sepatu Cibaduyut Kota Bandung)
Authors: Destany Zessy Rizkia , Suhaeni Tintin , Ivon Sandya Sari Putri  
Published: March 2024

The Cibaduyut shoe industry is one of the creative industries in the city of Bandung which has experienced a decline in turnover, this happens because there are several problems related to the entrepreneurial competence of entrepreneurs. In addition, the decline in turnover illustrates that Cibaduyut Shoes are not able to compete with its competitors. The purpose of this study to determine entrepreneurial competence, competitive advantage, and determine the effect of entrepreneurial competence on competitive advantage in the Cibaduyut shoe industry. The research method uses a descriptive survey with a quantitative approach and simple regression analysis. The sample of this study was 122 respondents consisting of owners and employees. The results showed that the entrepreneurial competence and competitive advantage of the Cibaduyut Shoes Industry were in the good category. Then it is known there is a positive and significant influence between the variables of entrepreneurial competence on competitive advantage of 13.8%.
Pengaruh Leverage, Capital Intensity dan Likuiditas Terhadap Agresivitas Pajak Pada Subsektor Kimia Yang Terdaftar di BEI
Authors: Kasir  
Published: March 2024

Tujuan penelitian ini untuk mengetahui pengaruh Leverage (DER), Capital Intensity dan Likuiditas (CR) terhadap Agresivitas Pajak (ETR) pada perusahaan subsektor kimia yang terdaftar di Bursa Efek Indonesia periode 2013-2020. Data yang digunakan adalah data sekunder. Model regresi yang dipergunakan Analisa Regresi Berganda.
Hasil penelitian ini secara uji t menunjukan bahwa Capital Intensity berpengaruh terhadap Agresivitas Pajak akan tetapi Leverage dan Likuiditas tidak berpengaruh terhadap Agresivitas Pajak. Untuk uji F (simultan) menyatakan bahwa Capital Intensity, Leverage dan Likuiditas secara simultan berpengaruh terhadap Agresivitas Pajak, dengan koefisien determinasi menunjukkan pengaruh secara simultan sebesar 15,0%. Sedangkan sisanya 85,0% dipengaruhi oleh faktor lain yang tidak di masukan dalam penelitian ini, seperti net profit margin, size dan lain sebagainya.
Perspektif Ekonomi Islam Terhadap Praktik Kerjasama Penjualan Hasil Pertanian (Studi Kasus di Kelompok Tani Barurejo Desa Alasrejo Kec. Wongsorejo Kab. Banyuwangi)
Authors: Rafik Zainur , Akbarul Muslim Alif , Fardany Kawakibi M. 
Published: March 2024

Kelompok tani sebagai wadah bagi para petani untuk penguatan dan peningkatan ekonomi para petani. Seperti anggota yang menjual hasil pertaniannya secara langsung kepada pedagang, hal ini dapat memicu adanya permainan harga (monopoli harga) dari pihak pedagang yang dapat merugikan anggota yang tentunya keluar dari ketentuan ekonomi islam. Fokus yang akan dibahas dalam karya ilmiah ini yakni mencakup tentang Pertama, Bagaimana praktik kerjasama penjualan hasil pertanian di kelompok tani barurejo desaAlasrejoKec.WongsorejoKab.Banyuwangi.Kedua,BagaimanaPerspektifekonomiislamterhadappraktikkerjasama penjualan hasil pertanian di kelompok tani barurejo desa AlasrejoKec. Wongsorejo Kab. Banyuwangi.
Untukmemudahkanpemahamandalampenelitianini,makapenelitimenggunakanmetodepenelitianKualitatifdenganpendekatanStudiKasus(FieldResearch).Teknikanalisadatayangdilakukanpenelitiyaknimengembangkan pertanyaan kemudian menganalisis dan menentukan hipotesisawal, serta memberikan dasar bagi analisis setelah pengumpulan data ( analisisafterdatacollection).
Darihasilpenelitianyangpenelitilakukandapatditarikkesimpulanbahwa, Pertama, anggota kelompok tani yang menjual hasil panennya kepadakelompok tani yang nantinya akan diterapkandari hasil penjualan tersebut akandiberlakukan kepada setiap anggota untuk menyerahkan 5 (lima) persen darihasilpenjualansebagaisimpananpokokyangnantinyaakandiberdayakankembaliuntukkeberlangsungandankemakmuranparaanggota.Kedua,Kelompoktanibarurejo hadir dengan mengedepankan prinsip keadilan yangsesuai dengan perspektif ekonomi islam dimana, meliputi seluruh aspek dasarperekonomianMasyarakatdesaAlasrejoKecamatanWongsorejo KabupatenBanyuwangi.
Feature correlation method for image reconstruction evaluation in under-sampled scanning probe microscopy
Authors: Ueda Keiichi , Diao Zhuo , Hou Linfeng , Yamashita Hayato , Abe Masayuki 
Published: March 2024

Abstract
We introduce an advanced feature-correlation approach for evaluating the accuracy of data completion in scanning probe microscopy (SPM). Our method utilizes characteristic patterns from conventional SPM images and their reconstructions via data interpolation. We develop a refined comparative evaluation algorithm based on correlation coefficients. This algorithm provides a precise assessment by effectively addressing SPM-specific distortions such as thermal drift, feedback error, and noise limitations often overlooked by traditional metrics such as peak signal-to-noise ratio and structural similarity index measure. The effectiveness of our approach is demonstrated through its application in high-resolution and extensive scanning tunneling microscopy assessments.
Influência do hábito tabagista na auto percepção de saúde bucal em pacientes periodontais
Authors: Ramon Johnatan Gabriel , Piardi Rafaela , Galafassi Daniel , Conde Alexandre , Pereira Butze Juliane 
Published: March 2024

Objetivos: avaliar a influência do hábito tabagista na autopercepção da saúde bucal de pacientes periodontais, avaliando, também, a observação ou não de sinais demonstrados em quadros de doença periodontal. Métodos: pacientes que estavam em atendimento no serviço de Triagem da Clínica do curso de Odontologia do Centro Universitário da Serra Gaúcha – FSG, entre os meses de agosto e outubro de 2022, foram convidados a participar da pesquisa. O questionário utilizado foi o desenvolvido por PACHECO et al. (2014), adaptado para abranger as necessidades do estudo. Foram abordadas perguntas relacionadas aos dados pessoais (idade, gênero), grau de escolaridade, motivo da consulta, hábitos de higiene bucal (recursos usados e frequência), hábitos de vida (tabagismo) e questionário adaptado sobre autopercepção da condição periodontal como prevenção, sinais clínicos e características das doenças periodontais. Resultados: a pesquisa teve um total de 65 pacientes. Destes, 37 (56,9%) eram mulheres e 28 (43,1%) eram homens. A média de idade dos participantes foi de 50 anos, em diversos graus de escolaridade, se demonstrando predominante o ensino médio completo e superior incompleto. Em relação ao hábito tabágico, com a inclusão de 31 tabagistas, 18 (58,1%) eram homens e 13 (41,9%) eram mulheres. O tempo de hábito tabagista obteve uma média de 23,8 anos, e 14 cigarros fumados ao dia. Observou-se que, apenas 5 pacientes tabagistas descreveram sua saúde bucal como boa, diante de 17 não tabagistas com a mesma resposta. Apenas 4 não tabagistas descreveram-na como ruim, ao contrário de 12 pacientes que fazem uso do tabaco. Com isso, 23 dos tabagistas com a resposta “ruim” ou “regular” afirmaram acreditar que sua saúde bucal não encontra-se “boa” por interferência do hábito tabagista. Conclusão: a autopercepção de saúde bucal em pacientes periodontais é influenciada pelo consumo do tabaco, causando uma percepção de ausência de saúde bucal e maior necessidade de tratamentos odontológicos.
Dietary Diversity in Adolescents at State Junior High School 4 Depok, Sleman Regency, Yogyakarta: A Descriptive Study
Authors: Wulan Yuni Kartika , Prasetyaningrum Yunita Indah , Kadaryati Sri , Wardani Desy Fitria 
Published: March 2024

Adolescents require balanced nutrition for their future growth and development. Adolescence is a time when there is a high risk of weight gain, especially in eating habits. A diverse diet for adolescents makes it easier to fulfill their need for various nutrients. This study aims to describe the dietary diversity of adolescents in state junior high school 4 Depok, Sleman Regency, Yogyakarta. This research was quantitative, using an analytic observational approach and a cross-sectional design. A purposive sampling technique was used to select 41 respondents. IDDS (Individual Dietary Diversity Scores) was used to measure dietary diversity based on nine food groups such as starch; green vegetables; vitamin A-rich fruits and vegetables; other fruits and vegetables; organ meats; fish, meat, and other processed meats products; legumes, nuts, and seeds; and dairy products. The majority of the adolescents, i.e. 21 individuals (51.2%), had a medium dietary diversity, while the remaining 20 individuals (48.8%) had a low dietary diversity. The adolescents consumed mainly starch (staple foods), other fruits and vegetables; eggs; fish, meat, and processed products; and dairy products. Adolescents from state junior high school 4 Depok Sleman Yogyakarta were mainly classified as having medium dietary diversity.Â Keywords: adolescents, dietary diversity, school age
Colonoscopy Finding: Pseudomembranous Colitis in Chronic Kidney Disease Patient
Authors: Febrianti Ety , Vidi Orba Busro  , Suyata  
Published: March 2024

Background: Gastrointestinal symptoms are common among patients with chronic kidney disease, reported in up to 70%–80% of patients with end-stage kidney disease. Several factors are involved in the pathogenesis, including the accumulation of uremic toxins and intestinal flora changes. Pseudomembranous colitis is a manifestation of severe colonic disease that is usually associated with Clostridium difficile infection but can be caused by a number of different etiologies. Pseudomembranous colitis occurs when changes in the fecal flora allow Clostridium difficile overgrowth. Gut dysbiosis, an alteration of the composition and function of gut microorganisms, is commonly seen in patients with chronic kidney disease.
Case presentation: This scientific report presents a case study of a 31-year-old woman diagnosed with pseudomembranous colitis and end-stage chronic kidney disease on hemodialysis. The colonoscopy showed yellow-white nodules that formed pseudomembranes, which were scattered between the edematous mucosa. The patient had been treated with metronidazole for 4 days, but there were side effects. The antibiotic was switched to meropenem for 6 days based on feces culture. The evaluation of colonoscopy result was normal.
Conclusion: Pseudomembranous colitis is an inflammatory bowel condition most commonly caused by Clostridium difficile infection. The presence of pseudomembranous visualization in colonoscopy can significantly establish the diagnosis.
KEEFEKTIFAN PENGGUNAAN SOSIAL MEDIA SEBAGAI PENDUKUNG STRATEGI PEMASARAN PADA UMKM KECAMATAN MARPOYAN DAMAI, PEKANBARU, RIAU
Authors: Yulita Rahmayulita 
Published: March 2024

Para pelaku UMKM yang menggunakan sosial media sebagai sarana berbagi informasi tentang produk yang ditawarkan kepada konsumen secara online lebih membantu mereka dalam mempromosikan produk mereka kepada masyarakat luas. Maka dalam pelaksanaan kegiatan Pengabdian Kepada Masyarakat ini, diperoleh wawasan keefektifan penggunaan sosial media sebagai pendukung strategi pemasaran pada UMKM sangat baik apabila dilakukan secara optimal dari segi lamanya waktu promosi dan adanya pengembangan produk.Ada beberapa permasalahan yang dihadapi oleh mitra khususnya pada kegiatan pengabdian kepada masyarakat ini antara lain masih kurangnya pengetahuan pelaku usaha dalam penggunaan alat atau instrumen digital sebagai salah satu langkah dalam melaksanakan kegiatan strategi pemasaran yang pada akhirnya akan meningkatkan pendapatan pada pelaku usaha tersebut. Metode pengabdian masyarakat ini dilaksanakan
dengan cara tatap muka kepada UMKM yaitu dengan mewawancarai langsung pemilik UMKM dengan memberikan penjelasan kepada pihak UMKM mengenai pentingnya memasarkan produk dengan menggunakan sosial media serta membantu membuat postingan yang menarik sebagai salah satu cara untuk membantu para UMKM dalam memasarkan atau mempromosikan dagangan/jualannya ke sosial media agar banyak diketahui orang luar
PERHITUNGAN HARGA POKOK PRODUKSI DAN PENYUSUNAN LAPORAN KEUANGAN PADA USAHA VCO BERTUAH DI PERUMAHAN HARIGUNA RT. 04 / RW. 11 KEL. SIDOMULYO BARAT, KEC. TAMPAN KOTA PEKANBARU
Authors: Sitinjak Marnala 
Published: March 2024

Pengabdian masyarakat merupakan suatu bentuk perkuliahan melalui kegiatan bekerja secara langsung di dunia kerja. Pengabdian masyarakat ini merupakan suatu kegiatan tri dharma bagi tenaga pendidik (Dosen). Kegiatan Pengabdian masyarakat ini dilaksanakan di VCO Bertuah. Pemilihan lokasi pengabdian masyarakat di VCO Bertuah ini dengan alasan karena VCO Bertuah merupakan salah satu UMKM yang belum memiliki laporan keuangan dan belum mengerti dalam pembuatan laporan keuangan UMKM yang sesuai dengan SAK EMKM. Hasil dari kegiatan pengabdian masyarakat ini dapat disimpulkan bahwa masih kurangnya pengetahuan pelaku usaha dalam menghitung harga pokok produksi serta menyusun laporan keuangan usaha sehingga sangat memerlukan perhatian atau arahan dalam menyusun dalam menghitung harga pokok produk maupun laporan keuangannya
SOSIALISASI PENYUSUNAN LAPORAN KEUANGAN SEDERHANA BAGI UMKM
Authors: Ningsih Fitria Eka 
Published: March 2024

Dampak Pandemi Covid-19 sangat luar biasa khususnya kepada para pelaku bisnis seperti UMKM, para pelaku atau pegiat UMKM sudah banyak yang gulung tikar akibat dampak tersebut. Diperkirakan setengah dari jumlah pelaku UMKM di Indonesia mengalami kebangkrutan. Terdapat beberapa penyebab resiko kerugian yang berakhir dengan kebangkrutan namun sebenarnya dapat diantisipasi oleh pihak UMKM. Salah satunya adalah kurangnya wawasan atau pengetahuan pelaku UMKM dalam menyusun laporan keuangan. Selama ini para pelaku UMKM pada umumnya hanya berfokus pada bagaimana menjalankan strategi pemasaran yang effective agar bisnisnya mendapatkan hasil penjualan secara maksimal. Para pelaku UMKM tersebut kurang menyadari betapa pentingnya laporan keuangan dalam penentuan keputusan yang tepat, sehingga mereka tidak memiliki data rill untuk mengevaluasi perkembangan bisnisnya. Hal ini lah yang menjadi resiko yang besar atas terjadinya kebocoran dana, pembengkakan pengeluaran dan masih banyak lagi resiko lainnya yang berujung pada kebangkrutan.
Untuk mencegah kebangkrutan UMKM yang disebabkan oleh karena tidak adanya laporan keuangan adalah dengan memberikan edukasi dan sosialisasi mengenai pentingnya laporan keuangan dan bagaimana cara membuat atau menyusun laporan keuangan sederhana bagi para pelaku UMKM. Kegiatan ini akan dilakukan di Pondok Pesantren Lembaga Bina Santri Mandiri yang berlokasi di desa Pondok Udik, Kecamatan Bogor. Metode pelaksanaan kegiatan PKM ini adalah dengan cara penyuluhan atau sosialisasi yang diawali dengan memberikan pre-test bagi para peserta, pemberian materi oleh narasumber, diskusi dengan narasumber, dan diakhiri dengan kegiatan post-test. Pre-test dan post-test dilakukan guna mengukur sejauh mana peningkatan pemahaman peserta setelah diberikan materi oleh narasumber.
Adapun output yang diharapkan dari kegiatan ini adalah membantu para wirausahawan khususnya para santri di Pondok Pesantren Lembaga Bina Santri Mandiri untuk memahami pentingnya laporan keuangan untuk bisnis yang mereka jalankan, Adapun luaran lainnya adalah dalam bentuk jurnal yang nantinya akan dipublikasikan sehingga dapat diakses dengan mudah bagi siapa saja yang membutuhkan informasi ataupun referensi sehubungan dengan cara menyusun laporan keuangan sederhana.