bluuebunny/crossref_metadata_2025_split huggingface dataset:
Time-dependent recovery of renal impairment in patients with newly diagnosed multiple myeloma
Authors: Utsu Yoshikazu , Isono Yuki , Masuda Shin-ichi , Arai Hironori , Shimoji Sonoko , Matsumoto Rena , Tsushima Takafumi , Tanaka Kazusuke , Matsuo Kosuke , Kimeda Chiharu , Konno Shiho , Yano Yudai , Kuramoto Nobuhiko , Aotsuka Nobuyuki 
Published: March 2024

Abstract

Renal impairment is reported in 20–50% of patients with newly diagnosed multiple myeloma and is known as a poor prognostic factor. Although several studies have demonstrated that treatment with novel antimyeloma agents improves renal impairment and myeloma itself, the time-dependent clinical course of recovery of renal function has not been extensively studied. We retrospectively collected the data of characteristics and outcomes in consecutive unselected patients diagnosed with and treated for symptomatic multiple myeloma between January 2015 and December 2022, and extracted and analyzed the cases with renal impairment. Among 234 patients with multiple myeloma, 67 (28.6%) had renal impairment (estimated glomerular filtration rate (eGFR) < 60 ml/min/1.73m2) at the time of diagnosis. The median eGFR at diagnosis was 28 ml/min/1.73m2, and the eGFR significantly improved to 41.5 ml/min/1.73m2, which corresponds to a 42.9% increase, at 3 months after the initiation of treatment for myeloma (p < 0.0001). Further improvement in renal function was not observed at 6 months (eGFR 46 ml/min/1.73m2) and 1 year (eGFR 43.5 ml/min/1.73m2) after treatment initiation. The primary treatment was a bortezomib-containing regimen in approximately 90% of patients. A post hoc analysis revealed a positive correlation between the serum calcium concentration at diagnosis and improvement in renal function. In conclusion, renal function can partially recover through the treatment of multiple myeloma, and the treatment response during the first 3 months may predict the renal function prognosis. Further accumulation of cases is needed to identify the predictive factors for renal recovery.
The Perceived Nursing Students’ Psychological Health Issues of Depression and Academic Stressors
Authors: Andargeery Shaherah Yousef 
Published: March 2024

Abstract
Background
Depression has been found in the literature as the most common health issue that confronts students during their education. The academic demands and pressure put nursing students at increasing risk of depression. Nursing students are the future of nursing workforce, while nursing education is the vital place to mitigate the impact of psychological health and factors that influence nursing students’ academic performance.
Aims
To (1) Examine the perceived level of depression and academic stress; (2) Determine differences in mean scores between groups of demographic variables on depression; and (3) Examine the association between depression and academic stress among nursing students in Saudi Arabia.
Design:
A cross-sectional, descriptive, and correlation study.
Method
An online self-administered questionnaire was used to collect the data by using the depression subscale from DASS-21 to measure depression and Academic Stress Inventory (ASI) scale to measure academic stress.
Results
A total of 237 undergraduate students participated in the study. Nursing students perceived mild level of depression and moderate level of overall academic stress. Students perceived moderate levels in all ASI subscales, except time management and test stress were high. Demographics showed significant differences in the means of depressive symptoms, except GPA, place of residence, and chronic illnesses. The overall ASI scale and subscales showed statistically significant correlations with depression. The strongest correlation was between studying in group stress subscale and depression, yet the least correlation was between result stress subscale and depression.
Conclusion
Nursing students need support especially during their first year of education. Counseling sessions, continues observation, and follow-up with the intervention programs must be implemented carefully to alleviate students’ stress and control their depression.
Comparative assessment of quality of life among adolescents with sickle cell disease and sickle cell trait: evidence from Odisha, India
Authors: Bindhani Basanta Kumar , Nayak Jayanta Kumar 
Published: March 2024

Abstract
The present study aims to assess the quality of life (QOL) of adolescents with sickle cell disease (SCD) and sickle cell trait (SCT) in hard-to-reach regions in Koraput district of Odisha state. 387 adolescents with sickle cell genes (HbSS = 52, HbAS = 135, HbA = 200) were selected through their medical records from southern parts of Odisha. To assess the QOL, a validated and pretested QOL scale was modified. The questionnaires were modified by aiming to describe the proportion of adolescents who feel restricted in different domains along with measuring the extent within each domain or finding an aggregate score of QOL. Furthermore, to explore the expenditure on health, 552 households were selected randomly, of which 72 families had HbS individuals. This study found a significantly lower health-related quality of life (HRQOL) in adolescents with SCD. However, most psychosocial sub-domains, for instance, worry about the illness, frequency of angry days, feeling jealousness toward other normal adolescents, and negative feelings of sadness on some days, are similarly affected in adolescents with SCT and SCD. The overall QOL of SCD individuals is more affected (percentage of affected mean score = 60.93%), followed by SCT individuals (35.63%). Healthy adolescents' QOL is relatively unaffected (13% were affected). The yearly frequency of blood transfusion received (1.7 ± 0.4) and hospitalization (2.1 ± 0.9) was significantly higher in adolescents with SCD. The healthcare expenditure was significantly higher (3.6–81.3% of the family income) in families with HbS than in families without HbS (0.8–19.2%) (p < 0.05). The overall QOL was affected in both SCD and SCT adolescents. The focus should be given equally to both SCD and SCT individuals, in spite of only SCD individuals.
Absorption-dominant electromagnetic interference (EMI) shielding cement with hollow glass microsphere (HGM) at elevated temperatures
Authors: Jang Daeik , Jang Woosuk , Bang Jinho , Park Junha , Kim Minkook , Yang Beomjoo 
Published: March 2024

Abstract

The rapid evolution and expansion of digital infrastructures has underscored the significance of electromagnetic interference (EMI) shielding composites. However, there has been a notable dearth of efforts to explore EMI shielding performance in the context of elevated temperatures. This study introduces hollow glass microspheres (HGM) to enhance the EMI shielding performance of carbon fiber (CF)-embedded conductive cement under elevated temperatures. Experimental outcomes delineate the impact of HGM inclusion on compressive strength, electrical and thermal conductivities, and EMI shielding performance. HGM incorporation is observed to reduce thermal conductivity, consequently improving EMI shielding performance at elevated temperatures by decreasing reflection and increasing absorption properties. The investigation incorporates comprehensive analyses, including XRD, TG, MIP, and micro-CT, to systematically examine the EMI shielding test outcomes at elevated temperatures. In conclusion, the utilization of HGM has the potential to yield super lightweight EMI shielding composites with enhanced EMI shielding performance at elevated temperatures.
Crithmum maritimum restores the lipid and metabolic profiles of liver cancer cells to a normal phenotype
Authors: Gnocchi Davide , Nikolic Dragana , Paparella Rosa Rita , Sabbà Carlo , Mazzocca Antonio 
Published: March 2024

Abstract
Hepatocellular carcinoma (HCC) is becoming an alarming epidemiological clinical problem worldwide. Pharmacological approaches currently available do not provide adequate responses due to poor effectiveness, high toxicity, and serious side effects. We previously demonstrated that the wild edible plant Crithmum maritimum effectively slows the growth of liver cancer cells in vitro by reducing the bioenergetic and metabolic characteristics typical of transformed cells, particularly the fermentative phenotype (Warburg effect). Moreover, we found that Crithmum maritimum improves the expression of markers of differentiated hepatocytes. Here, we aimed to further characterize the effects of Crithmum maritimum on lipid accumulation and metabolism in HCC cells with different degrees of transformation. Additionally, we wanted to study markers of cellular metabolic health, such as AMP-activated protein kinase (AMPK), Sirtuin 1 (SIRT1), and Sirtuin 3 (SIRT3), as well as the insulin signaling pathway. To better model the biological spectrum of HCC, we employed HCC cell lines with varying degrees of transformation and invasiveness. Results indicate that Crithmum maritimum prevents lipid accumulation, downregulates lipid and cholesterol biosynthesis, and modulates markers of metabolic health, such as AMPK, SIRT1 and SIRT3. This effect is differentially modulated in different HCC cell lines, revealing an important functional versatility of Crithmum maritimum. These findings confirm the importance of Crithmum maritimum as a valuable nutraceutical, reinforcing its role in improving metabolic health.
Prediction of Lymph Node Metastasis in Rectal Cancer Based on Super-Resolution MRI Radiomics and Clinical Baseline
Authors: Zhang Liang , Qu Xueting , Duan Feng , Lin Jizheng , Lou Henan , Wang Guohua 
Published: March 2024

Abstract

Objective
To explore the clinical practical value of the super-resolution(SR) MRI radiomics model based on clinical baseline for predicting lymph node metastasis in rectal cancer before surgery.
Methods
Retrospective inclusion of 302 eligible patients with rectal cancer (109 with lymph node metastasis). Patients from one hospital were included in the training set (n = 181), while patients from other hospitals were included in the external validation set (n = 121). Super-resolution algorithm was developed to axial T2-weighted imaging (T2WI) and subsequent SR-T2WI images were generated. The conventional radiomics models and SR radiomics model were built by 8 machine learning algorithms separately, and the best model was selected as the radiomics model. Using single-factor and multivariate logistic regression analysis to identify clinical risk factors for building a clinical model, and combining it with the radiomics model to construct a joint model. Comparing the diagnostic efficacy of the three models using area under the curve (AUC) in ROC curves. Finally, comparing the diagnostic efficacy of the best predicted model with different experienced radiologists.
Results
After feature screening and dimension reduction, 5 and 10 radiomics features were retained for conventional images and SR images, respectively. The diagnostic performance of the SR model on the external validation set was better than that of the conventional image model. Three clinical risk factors related to lymph node metastasis were screened to develop a clinical model. By combining SR radiomics features with clinical risk factors, a joint model was constructed, and compared with the three models, the joint model demonstrated the best diagnostic performance with an AUC, sensitivity, specificity and accuracy of 0.756 (95% confidence interval(CI): 0.658–0.854), 69.2%, 75.6%, and 73.6% on the external validation set, which was superior to that of a radiology expert with 36 years of experience (AUC, sensitivity, specificity, and accuracy of 0.679 (95% CI: 0.588–0.830), 84.6%, 51.2%, and 62.0%) on the external validation set (P = 0.02), indicating high clinical utility value.
Conclusion
The SR MRI radiomics model based on clinical baseline has high clinical practical value in predicting lymph node metastasis before surgery of rectal cancer.
Exploration of approaches to locate charging stations for a private electric delivery fleet
Authors: Kunapareddy Vamsi Krishna , Batta Rajan 
Published: March 2024

Abstract
This paper explores approaches to find optimal locations for charging stations in the context of a private delivery company that is attempting to electrify its fleet of delivery vehicles. Although the possible total set of customers is known in advance, the organization has uncertainty in realizing the actual customers on a particular day and this ambiguity leads to uncertainty in the location of charging stations. To address this, we divide the routes based on their frequencies as frequent and infrequent. We further consider three sets of frequent routes and develop three sets of models and heuristics that determine the locations of the charging stations. The first model maximizes the number of chargers located on arcs which are common to multiple routes. The second model explores the possibility of locating chargers at the customer locations as a combinatorial problem and solves it to optimality. The last model, which considers routes with chargers on the last arcs of two or more different routes, consolidates those stations. To showcase the efficacy and efficiency of our proposed approaches, we present results obtained by applying these models to various instances. We find that, although the number of routes that can fall into the first set is comparatively less, the algorithm reduces the chargers that should be located in those routes. The total time spent on routes in the second set is reduced by almost 15 percent on average. For the last set, the important metric while evaluating the efficacy of the model is the increase in travel time, which is relatively small for the number of chargers that are being consolidated. These findings can serve as valuable insights for decision-makers planning to electrify their fleet.
Primary Sites and Clinicopathological Features of Corneal Melanoma: A SEER Population-Based Study of 29 Cases
Authors: Suh Alexander , Huang Maggie , Lian Isabelle , Tsang Preston , Ledet Elisa , Li Jian , Nguyen Andre , Dang Peyton , Dang Nguyen Duc Dinh , Tran Kenneth 
Published: March 2024

Abstract
Introduction
Corneal Melanoma (CM) is a rare malignancy that develops from melanocytes within the cornea, constituting a minority of all ocular tumors. In this study, we sought to investigate the clinicopathological characteristics correlated with the prognosis of CM patients.
Methods
We collected patients with CM between 1983 and 2018 from the Surveillance, Epidemiology, and End Results (SEER) database. Cox proportional hazards regression was used for univariate analysis to value hazard ratio (HR) of malignant CM versus spindle cell melanoma and nodular melanoma subgroups.
Results
A total of 29 eligible patients were collected in our study. Age at diagnosis, laterality, primary site, tumor size, the extent of disease, marital status, income, residential area, and treatment showed no significant prognostic factors for CM patients (P > 0.05). However, when concerned with the primary site of malignant melanoma, spindle cell melanoma (P < 0.05) and nodular melanoma (P < 0.05) were found to show significantly poorer prognosis in CM patients.
Conclusion
Age at diagnosis, laterality, primary site, tumor size, the extent of disease, and treatment were not significant prognostic indicators for CM patients. Spindle cell melanoma and nodular melanoma were notable for showing worse survival outcomes than malignant melanoma. Although the sample size in the SEER database was limited, our findings may provide motivation for tailoring individualized treatments for patients with CM with different primary sites.
Understanding care seeking behavior for reproductive tract infections among Afghan women: A cross-sectional study
Authors: Martellucci Cecilia Acuti , Mohammady Nooria , Negin Fawzia , Mosavi Sayed Hamid , Miranda Adriana Viola , Safa Husna , Qasimi Bibi Qudsia , Mosavi Khaterah , Bek Basira , Azimi Alisina , Annabi Zahra , Noorzai Saddiqa , Rahimee Aabidullah , Balaghat Taha , Rezaie Fatema , Temory Fardına , Ramozi Mirwais , Martellucci Mosè , Bek Rahila , Noroozi Shabana , Niro Madina , Sultani Husna , Farooqi Palwasha , Shayan Ehsan , Zhwand Mohammadgul , Rezaee Qasem , Torgani Farzana , Hussaini Bibi Shakiba , Akhtiyari Shaqaiq , Qaderi Farah , Qaderi Shohra 
Published: March 2024

Abstract
Background
In Afghanistan, a country with limited resources, providing care for Reproductive Tract Infections (RTIs) is challenging, also due to the extreme scarcity of reliable data. To address this gap, the present study investigates symptoms, potential risk factors, knowledge, and care-seeking behavior in the largest sample of women to date.
Methods
From September 16 to November 26 2022, a structured questionnaire was administered, by trained female medical students, to women presenting at multi-specialist clinics in the major cities of Afghanistan. Signs and symptoms of RTIs were investigated, together with reproductive history, hygiene practices, and socio-demographic characteristics. Logistic regression, adjusted for selected co-variates, was used to assess predictors of delays (over one month) from symptoms onset to care-seeking, and of a history of RTI.
Results
Out of 749 women who were asked to reply to the questionnaire, 601 responses were analyzed (80.2%). Mean age was 31.3 years (SD 11.5), with 69.1% being younger than 35 years, 26.8% unmarried, and 32.5% illiterate. Respectively 77.1% and 40.8% of the women had their first marriage and their first delivery between 14 and 20 years of age. Signs and symptoms related to RTIs were reported by 79.2%, knowledge of RTIs by only 23.0%, and care-seeking delays by up to 39.5%, of which 68.2% cited reasons other than mismanagement at the previous clinic. Care-seeking delays were positively associated with abnormal vaginal discharge (OR 4.12; 95%CI 2.01–8.45), lower abdominal pain (2.62; 1.44–4.77), and fever (1.93; 1.25–2.98) and negatively associated with being sedentary (0.38; 0.22–0.64), hand-washing (0.61; 0.40–0.95), and knowledge about RTI () although borderline significant. A history of RTI (reported by 44.1%) was predicted by abnormal vaginal discharge (2.29; 1.38–3.79), fever (1.56; 1.04–2.36), irregular menstruations (1.59; 1.07–2.35), and use of sanitary pads (vs. cloth: 0.63; 0.41–0.97), but not by the husbands’ history of RTI.
Conclusions
The majority of women presenting at clinics in Afghanistan reported signs and symptoms related to RTIs, delayed care-seeking, and lack knowledge about RTI. Healthcare providers should inform the population about RTIs and their standard care pathway, while adopting a multi-dimensional approach accounting for the cultural background of the women.
Retrospective analysis of telematic glaucoma clinic as a consequence of COVID-19 pandemic
Authors: Sánchez Adrian Sánchez-Fortún , Romero Pau Romera , Artigas Ricard Mellado , García Jessica Botella , Arenas Jordi Loscos , Sánchez Sandra Gómez , Llopart Antoni Sabala 
Published: March 2024

Abstract

PURPOSE Due to COVID-19 pandemic, the glaucoma clinic had to adapt to meet the needs of this chronic disease. New technologies allowed us to monitor some of these patients in a telematic way.
METHODS We retrospectively analyzed patients with-open angle glaucoma who were visited between September 2021 and March 2022, and compared Visual Field (VF) and Optical Coherence Tomography (OCT) parameters depending on whether they had telematic or only face-to-face controls. All patients were stratified in each group according to glaucoma severity.
RESULTS A total of 204 eyes from 118 patients were included in the analysis, with 100 in the group with only face-to-face controls (group 1/FTF) and 104 with some telematic control (group 2/HG). In group 2/HG, an average of 3.37 face-to-face visits and 1.27 telematic visits were made, while group 1/FTF had 4.4 face-to-face visits. There was no significant difference between the pre-pandemic and 2 years after it visits, neither in Visual Accuity, OCT and VF parameters. Regarding glaucoma severity, there were more cases of severe glaucoma in group 1/FTF and more cases of mild glaucoma in group 2/HG.
CONCLUSIONS Telematic management of the glaucoma clinic, with the use of appropriate tools, can be useful for maintaining the quality of care during periods of face-to-face consultations saturation or when face-to-face control is completely impossible.
Beyond One-Shot Explanations: A Systematic Literature Review of Dialogue-Based XAI Approaches
Authors: Mindlin Dimitry , Beer Fabian , Sieger Leonie Nora , Heindorf Stefan , Cimiano Philipp , Esposito Elena , Ngonga-Ngomo Axel-Cyrille 
Published: March 2024

Abstract

In the last decade, there has been increasing interest in allowing users to understand how the predictions of machine-learned models come about, thus increasing transparency and empowering users to understand and potentially contest those decisions.Dialogue-based approaches, in contrast to traditional one-shot eXplainable Artificial Intelligence (XAI) methods, facilitate interactive, in-depth exploration through multi-turn dialogues, simulating expert conversations. This paper reviews the current state of dialogue-based XAI, presenting a systematic review of 1,339 publications, narrowed down to 14 based on inclusion criteria. We explore theoretical foundations of the systems, propose key dimensions along which different solutions to dialogue-based XAI differ, and identify key use cases, target audiences, system components, and the types of supported queries and responses. Furthermore, we investigate the current paradigms by which systems are evaluated and highlight their key limitations. Key findings include identifying the main use cases, objectives, and audiences targeted by dialogue-based XAI methods, and summarize the main types of questions and information needs. Beyond discussing avenues for future work, we present a meta-architecture for these systems from existing literature and outlined prevalent theoretical frameworks.
A new global land-ocean merged surface temperature dataset since the 1850s: the CMA-GMST dataset
Authors: Chen Lifan , Xu Wenhui , Zhou Zijiang , Cao Lijuan , Yang Su , Xu Chengdong 
Published: March 2024

Abstract
A new global land-ocean merged surface temperature dataset, China Meteorological Administration global merged surface temperature (CMA-GMST), is developed. It is constructed from the monthly China Meteorological Administration global reconstructed land surface temperature (CMA-GLST) and sea surface temperature (CMA-SST) analyses that benefit from the improved in-situ observation coverage. Besides, the Arctic ice covered area is also reconstructed based on air temperatures and merged into CMA-GMST. This dataset provides a spatial complete and homogeneous surface temperature anomaly field in 2°×2° resolution for each month since 1850, and covers the majority of the earth’s surface: reaches 90% in the middle 1950s and exceeds 99% from the late 1970s. Assessments show that the observed global and regional (terrestrial, oceanic and hemispheric) trends of the annual average anomalies from CMA-GMST agree well with the ranges of trends computed from other published surface temperature analyses. The trends over the different latitudinal zones are also broadly in line with other published surface temperature analyses, while there are some differences in regions with limited observations among the datasets, such as the region of 90S–60ºS. Besides, evaluations by CMA-GMST show that the year 2023 was the warmest year on record and each month from July 2023 to December 2023 ranked as the globe's hottest month in recorded history, which agree well with the evaluations from other published surface temperature analyses.