bluuebunny/crossref_metadata_2025_split huggingface dataset:
Highly Efficient and Stereoselective N‐Vinylation of Oxiranecarboxamides and Unprecedented 8‐endo‐Epoxy‐arene Cyclization: Expedient and Biomimetic Synthesis of Some Clausena Alkaloids.
Authors: Yang Luo , Deng Gang , Wang De‐Xian , Huang Zhi‐Tang , Zhu Jie‐Ping , Wang Mei‐Xiang 
Published: July 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Anionic [4 + 2] Cycloaddition Strategy in the Regiospecific Synthesis of Carbazoles: Formal Synthesis of Ellipticine and Murrayaquinone A.
Authors: Mal Dipakranjan , Senapati Bidyut Kumar , Pahari Pallab 
Published: July 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Novel Divergent Synthesis of ortho‐Hydroxy‐E and ‐F Oxide‐Bridged 5‐Phenylmorphans.
Authors: Zezula Josef , Jacobson Arthur E. , Rice Kenner C. 
Published: July 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Four New Topological Indices Based on the Molecular Path Code.
Authors: Balaban Alexandru T. , Beteringhe Adrian , Constantinescu Titus , Filip Petru A. , Ivanciuc Ovidiu 
Published: July 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Novel Approach for the Numerical Characterization of Molecular Chirality.
Authors: Natarajan Ramanathan , Basak Subhas C. , Neumann Terence S. 
Published: July 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Molecules in silico: A Graph Description of Chemical Reactions.
Authors: Kerber Adalbert , Laue Reinhard , Meringer Markus , Ruecker Christoph 
Published: July 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Long‐Distance Structural Consequences of H‐Bonding. How H‐Bonding Affects Aromaticity of the Ring in Variously Substituted Aniline/Anilinium/Anilide Complexes with Bases and Acids.
Authors: Szatylowicz Halina , Krygowski Tadeusz M. , Zachara‐Horeglad Joanna E. 
Published: July 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Numerical Kekule Structures of Fullerenes and Partitioning of π‐Electrons to Pentagonal and Hexagonal Rings.
Authors: Randic Milan , Kroto Harry W. , Vukicevic Damir 
Published: July 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
QSAR Study of Antimicrobial Activity of Some 3‐Nitrocoumarins and Related Compounds.
Authors: Debeljak Zeljko , Skrbo Armin , Jasprica Ivona , Mornar Ana , Plecko Vanda , Banjanac Mihajlo , Medic‐Saric Marica 
Published: July 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Ensemle Feature Selection: Consistent Descriptor Subsets for Multiple QSAR Models.
Authors: Dutta Debojyoti , Guha Rajarshi , Wild David , Chen Ting 
Published: July 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Novel Logic‐Based Approach for Quantitative Toxicology Prediction.
Authors: Amini Ata , Muggleton Stephen H. , Lodhi Huma , Sternberg Michael J. E. 
Published: July 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis and Conformational and Biological Aspects of Carbasugars
Authors: Arjona Odon , Gomez Ana M. , Lopez J. Cristobal , Plumet Joaquin 
Published: July 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Application of Electronic Circular Dichroism in Configurational and Conformational Analysis of Organic Compounds
Authors: Berova Nina , Di Bari Lorenzo , Pescitelli Gennaro 
Published: July 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Cambodian cancer incidence rates in California and Washington, 1998–2002
Authors: Kem Ravie , Chu Kenneth C. 
Published: July 2007

AbstractBACKGROUND.Among the many diverse Asian ethnic groups living in the US, Cambodian immigrants comprise a small fraction (1.8%) of the total Asian population. Because of their small numbers, Cambodian vital statistics are often combined into Southeast Asian (SA) cancer data consisting of Vietnamese, Thais, Laotians, and Hmong.METHODS.The 2000 Census counts were used for 2 Cambodian populations, Cambodians alone and Cambodians alone and in combination with any other racial/ethnic group for California and for Seattle (Puget Sound area), Washington. Then the cancer incidence rates were calculated using cancer cases from the California and Puget Sound cancer registries between 1998–2002. The 1998–2002 annual age‐adjusted incidence rates, upper bound rates (based on the Cambodian alone population), lower bound rates (based on the Cambodians alone or in combination population) are reported and compared with the rates in the non‐Hispanic White (NHW) population in these regions.RESULTS.The top 5 cancers in Cambodian males are lung and bronchus, liver, prostate, colorectal, and stomach cancers. The sites where the rates are higher in male Cambodians than NHW males are (in ascending rank) nasopharynx, liver, stomach, myeloma, and lung and bronchus. The top 5 cancers for female Cambodians are breast, lung, colon and rectum, cervix, and thyroid. The sites where female rates are greater than NHW female rates are (in ascending rank) nasopharynx, liver, stomach, cervix uteri, oral cavity, and thyroid.CONCLUSIONS.The challenges to address the health issues of Cambodians are complicated by historical events that caused their emigration to the US. Many of the immigrants are survivors of the holocaust in Cambodia. Health programs for Cambodians must deal with the consequences of these issues as well as cultural issues of language and religion in helping Cambodians to reduce their cancer disparities. Cancer 2007. © 2007 American Cancer Society.
P2PPerf: a framework for simulating and optimizing peer‐to‐peer‐distributed computing applications
Authors: Ernst‐Desmulier J.‐B. , Bourgeois Julien , Spies François 
Published: July 2007

AbstractPeer‐to‐peer paradigm is more and more studied by the distributed computing community. Indeed, this type of architecture has interesting properties like the absence of centralized topology, fault tolerance or dynamic reorganization of the network. However, managing these networks is complex and the acceleration of the distributed applications is not ensured. That is why it is necessary to predict the performance as soon as possible in design and development phases, to bypass bottlenecks and to correct part of the applications that slow down the execution time. In this context, we propose P2PPerf: a simulation tool that aims at predicting performance and the execution time of a distributed application before its finalization. P2PPerf has been tested on JNGI: a P2P distributed computing application using the JXTA platform. Copyright © 2007 John Wiley & Sons, Ltd.
The determinants and characteristics of voluntary disclosure by Indian banking companies
Authors: Hossain Mohammed , Reaz Masrur 
Published: July 2007

AbstractThis study reports the results of an empirical investigation of the extent of voluntary disclosure by 38 listed banking companies in India. It also reports the results of the association between company specific characteristics and voluntary disclosure of the sample companies. The study reveals that Indian banks are disclosing a considerable amount of voluntary information. The findings also indicate that size and assets‐in‐place are significant and other variables such as age, diversification, board composition, multiple exchange listing and complexity of business are insignificant in explaining the level of disclosure. However, this paper has contributed to the academic literature that financial institutions provide voluntary corporate information including social information as discharging their social responsibility and corporate citizenship. Copyright © 2007 John Wiley & Sons, Ltd and ERP Environment.
Evaluating social performance in the context of an ‘audit culture’: a pilot social review of a gold mine in Papua New Guinea
Authors: Macintyre Martha , Mee Wendy , Solomon Fiona 
Published: July 2007

AbstractThe growth of sustainable development frameworks that emphasize the social dimension has created a need for new approaches to evaluate social performance. The paper describes the design and pilot of a social review conducted at the Lihir Gold Mine in Papua New Guinea. The aim was to investigate more integrated measures – understood as combining qualitative and quantitative measures, and bridging international and local community standards – of social performance. The paper discusses the demands of time and resources placed on a range of stakeholders as part of a review. It then identifies impediments to developing integrated approaches, and analyses these with reference to Power's (1999, 2003) discussion of an emerging audit culture, which focuses on management systems rather than first‐order questions of quality and performance. The authors conclude that, while an audit culture influenced this pilot study, an integrated approach on these two dimensions remains an achievable goal. Copyright © 2007 John Wiley & Sons, Ltd and ERP Environment.
A multi‐model approach to simultaneous segmentation and classification of heterogeneous populations of cell nuclei in 3D confocal microscope images
Authors: Lin Gang , Chawla Monica K. , Olson Kathy , Barnes Carol A. , Guzowski John F. , Bjornsson Christopher , Shain William , Roysam Badrinath 
Published: July 2007

AbstractAutomated segmentation and morphometry of fluorescently labeled cell nuclei in batches of 3D confocal stacks is essential for quantitative studies. Model‐based segmentation algorithms are attractive due to their robustness. Previous methods incorporated a single nuclear model. This is a limitation for tissues containing multiple cell types with different nuclear features. Improved segmentation for such tissues requires algorithms that permit multiple models to be used simultaneously. This requires a tight integration of classification and segmentation algorithms. Two or more nuclear models are constructed semiautomatically from user‐provided training examples. Starting with an initial over‐segmentation produced by a gradient‐weighted watershed algorithm, a hierarchical fragment merging tree rooted at each object is built. Linear discriminant analysis is used to classify each candidate using multiple object models. On the basis of the selected class, a Bayesian score is computed. Fragment merging decisions are made by comparing the score with that of other candidates, and the scores of constituent fragments of each candidate. The overall segmentation accuracy was 93.7% and classification accuracy was 93.5%, respectively, on a diverse collection of images drawn from five different regions of the rat brain. The multi‐model method was found to achieve high accuracy on nuclear segmentation and classification by correctly resolving ambiguities in clustered regions containing heterogeneous cell populations. © 2007 International Society for Analytical Cytology
Identification and characterization of a novel nonsecosteroidal vitamin D receptor ligand
Authors: Chen Fang , Su Qin , Torrent Maricel , Wei Nan , Peekhaus Norbert , McMasters Daniel , Fisher John , Glantschnig Helmut , Hodor Paul , Flores Osvaldo , Reszka Alfred 
Published: July 2007

AbstractVitamin D receptor (VDR) and its ligands play important roles in mineral/skeletal homeostasis, cell proliferation/differentiation, and modulation of immune responses. VDR ligands make attractive candidates for the treatment/prevention of osteoporosis, psoriasis, and cancer. The major issue with current analogs is hypercalcemia. As nonsteroidal therapeutic agents with fewer side effects have been made for androgen and estrogen receptors, nonsecosteroidal VDR ligands possessing beneficial effects may also be possible. Here we present a novel podocarpic acid‐based nonsecosteroidal VDR ligand (VDRL‐1). VDRL‐1 bound to VDR with a Ki of ∼1.3 µM in competition binding assays. Data from binding and molecular docking suggest that VDRL‐1 interacts with the same binding pocket as 1α,25‐(OH)2 vitamin D3 (1,25‐D3). In cell‐based transcription assays, VDRL‐1 reached the same maximal activity as 1,25‐D3, albeit with an EC50 ∼1.0 µM. Likewise, VDRL‐1 was a full agonist in suppressing proliferation of several human cancer cells. Microarrays demonstrated that VDRL‐1 exerted a near identical expression pattern to that of 1,25‐D3 in several human cancer cells. Taqman analysis of known and novel VDR‐regulated genes showed that VDRL‐1 was a full agonist on osteocalcin (OC), CYP24A1, and other genes. It exerted partial agonist activity on G0/G1 switch gene 2 (G0S2). Furthermore, VDRL‐1 could be a full or partial agonist of calcium transporter 1 (TRPV6) expression and partially antagonized 1,25‐D3 in cells where it partially regulated TRPV6. Thus, the current study describes a novel nonsecosteroidal VDR ligand that behaves mostly like 1,25‐D3, but possesses unique characteristics. Drug Dev Res 68:51‐60, 2007. © 2007 Wiley‐Liss, Inc.
The histone deacetylase inhibitor MS‐275 induces p21WAF1/Cip1 expression in human Hep3B hepatoma cells
Authors: Zhang Haiyuan , Chen Ping , Bai Shujun , Huang Canhua 
Published: July 2007

AbstractMS‐275 is a novel synthetic benzamide derivative histone deacetylase (HDAC) inhibitor, that has demonstrated antiproliferative activity in a variety of in vitro human cancer cell lines including breast, colon, lung, myeloma, ovary, pancreas, prostate, and leukemia. Currently, little information is available concerning the effects of MS‐275 on liver cancer cells. In the current study, MS‐275 was found to have potent actions against human hepatoma Hep3B cells including inhibition of cell proliferation and induction of apoptosis. MS‐275 selectively up‐regulated a cyclin‐dependent kinase inhibitor, p21WAF1/Cip1 without alteration of p27WAF1. Expression of p21WAF1/Cip1 is considered to play a pivotal role in Hep3B cell growth arrest and induction of apoptosis. Induction of p21WAF1/Cip1 expression was accompanied by an accumulation of acetylated histones H3 and H4 associated specifically with p21WAF1/Cip1 gene. ChIP analysis revealed remarkable alterations in protein components bound to the promoter region of p21WAF1/Cip1 gene in response to MS‐275 treatment. These included the degradation of HDAC1, HDAC3, and c‐Myc, and as well as increased p300 and RNA polymerase II. The selective effect of MS‐275 on the up‐regulation of the p21WAF1/Cip1 gene whose expression was suppressed in the hepatoma cancer cell line indicated that it would be a very attractive approach in clinical liver cancer therapy. Drug Dev Res 68:61–70, 2007. © 2007 Wiley‐Liss, Inc.
Effects of the Chinese herb component phellopterin on the increase in cytosolic free calcium in PC12 cells
Authors: Li Hai‐Tao , He Ling , Qiu Jia‐Bin 
Published: July 2007

AbstractThe present study investigated the effects of the Chinese Herb component, phellopterin on high K+ and glutamate‐induced extracellular calcium influx and caffeine or cyclopiazonic acid (CPA)‐induced calcium release from internal stores in attached PC12 cells. Attached cells were loaded with the calcium fluorescent indicator Fluo‐3/AM with the final concentration of 5 µM for 50 min at 37°C and cytosolic free Ca2+ measured as fluorescent intensity (FI) (excitation: 488 nm; emission: 535 nm). When PC12 cells were exposed to extracellular Ca2+([Ca2+]0) 2.0 mM, the FI for resting [Ca2+]i was 1,188±163, high K+ (75 mM) and glutamate (10 mM) induced an increase in [Ca2+]i with peak values of 4,270±982 and 3,096±402, respectively. Phellopterin (0.1–100 µM) had no apparent effect on resting [Ca2+]i, but inhibited high K+ and glutamate induced the increase in [Ca2+]i in a dose‐dependent manner. When PC12 cells were exposed to Ca2+‐free solution, the FI for resting [Ca2+]i was 804±77. Caffeine (40 mM) and CPA (30 µM) stimulated Ca2+ release from caffeine‐ryanodine and inositol 1,4,5‐tris‐phosphate (InsP3)‐sensitive internal calcium stores, inducing an increase in [Ca2+]i to 2,938±362 and 1,816±291, respectively. Phellopterin (0.1–100 µmol/L) inhibited caffeine and CPA stimulated intracellular calcium release in a dose‐dependent manner. In summary, phellopterin, a novel component isolated from Changii radix, inhibited Ca2+ influx induced by stimulation of voltage‐gated and receptor‐dependent calcium channels with a greater inhibition of receptor‐dependent calcium channels. It also inhibited Ca2+ release from caffeine‐ryanodine and InsP3‐sensitive internal stores, being more potent for caffeine stimulation. Phellopterin may be a promising candidate for the development of new classes of calcium antagonists. Drug Dev Res 68:79–83, 2007. © 2007 Wiley‐Liss, Inc.
Extrinsic versus intrinsic cues in avian paraxial mesoderm patterning and differentiation
Authors: Bothe Ingo , Ahmed Mohi U. , Winterbottom Farrah L. , von Scheven Gudrun , Dietrich Susanne 
Published: July 2007

AbstractSomitic and head mesoderm contribute to cartilage and bone and deliver the entire skeletal musculature. Studies on avian somite patterning and cell differentiation led to the view that these processes depend solely on cues from surrounding tissues. However, evidence is accumulating that some developmental decisions depend on information within the somitic tissue itself. Moreover, recent studies established that head and somitic mesoderm, though delivering the same tissue types, are set up to follow their own, distinct developmental programmes. With a particular focus on the chicken embryo, we review the current understanding of how extrinsic signalling, operating in a framework of intrinsically regulated constraints, controls paraxial mesoderm patterning and cell differentiation. Developmental Dynamics 236:2397–2409, 2007. © 2007 Wiley‐Liss, Inc.
BMP‐4 and Noggin signaling modulate dorsal fin and somite development in the axolotl trunk
Authors: Epperlein Hans H. , Vichev Konstantin , Heidrich Felix M. , Kurth Thomas 
Published: July 2007

AbstractBMP‐4, a member of the TGF‐beta superfamily of growth factors, is involved in various developmental processes. We investigated the effects of BMP‐4 and its antagonist Noggin on axolotl trunk development. Implantation of BMP‐4‐coated microbeads caused inhibition of muscle and dorsal fin formation in the vicinity of the microbeads. At some distance, myotomes developed with reduced height but increased width, which was accompanied by increased cell proliferation. These effects could be modulated by co‐implanting Noggin‐coated beads. Immunostaining of Pax7 further revealed that although the dermomyotome was absent in the vicinity of BMP‐4‐coated beads, at some distance from them, it was thicker than in controls, indicating that moderate amounts of BMP‐4 stimulate this layer of undifferentiated cells. In contrast, Noggin generally inhibited the dermomyotome, possibly indicating premature differentiation of dermomyotome cells. We conclude that BMP‐4 and Noggin are involved in the regulation of cell proliferation and differentiation during somite development. Developmental Dynamics 236:2464–2474, 2007. © 2007 Wiley‐Liss, Inc.
Flipping the switch: How a sperm activates the egg at fertilization
Authors: Parrington John , Davis Lianne C. , Galione Antony , Wessel Gary 
Published: July 2007

AbstractSperm interaction with an egg in animals was first documented 160 years ago in sea urchins by Alphonse Derbès (1847) when he noted the formation of an “envelope” following the sperm's “approach” to the egg. The “envelope” in sea urchins is an obvious phenotype of fertilization in this animal and over the past 35 years has served to indicate a presence of calcium released from cytoplasmic stores essential to activate the egg. The mechanism of calcium release has been intensely studied because it is a universal regulator of cellular activity, and recently several intersecting pathways of calcium release have been defined. Here we examine these various mechanisms with special emphasis on recent work in eggs of both sea urchins and mice. Developmental Dynamics 236:2027–2038, 2007. © 2007 Wiley‐Liss, Inc.
Conditional alleles of Msx1 and Msx2
Authors: Fu Hualin , Ishii Mamoru , Gu Ying , Maxson Robert 
Published: July 2007

AbstractThe msh‐related homeobox genes, Msx1 and Msx2, have a variety functions during murine organogenesis, Msx1 in the development of the palate and teeth, Msx2 in the skull, teeth, and skin. Msx1 mutants die perinatally. Compound Msx1‐2 mutants do not survive past late gestation. The multiplicity of functions of Msx1 and 2, as well as the lethality of Msx1 and Msx1‐2 mutants limits the utility of the conventional knockouts. We therefore produced conditional alleles of Msx1 and Msx2. We constructed targeting vectors with LoxP sites flanking the homeodomain‐encoding second exons and Frt sites flanking a neo gene. These vectors were used to produce targeted ES cells and mice with floxed alleles. The functionality of the LoxP sites in the floxed alleles was established by crosses with K14‐Cre mice (epidermis‐specific), and with an Msx2‐Cre line that produces a germline deletion. Analysis of progeny by PCR revealed correct Cre‐mediated recombination, as well as expected phenotypes. genesis 45:477–481, 2007. Published 2007 Wiley‐Liss, Inc.
Echo canceler algorithm for adaptive Volterra filters in double talk states
Authors: Takeichi Kaichiro , Furukawa Toshihiro , Mimura Masayoshi , Yoshimoto Sadanobu 
Published: July 2007

AbstractIn an acoustic echo canceler, it is necessary to consider the nonlinearity of an echo path in order to attenuate an echo signal conventionally, and various methods using adaptive Volterra filters have been proposed. Many of those methods have not resulted in a decisive solution about the double talk states in a nonlinear acoustic echo canceler. In this paper, we propose an echo canceler algorithm for adaptive Volterra filters using the idea of the OECLMS (Orthogonal Expanded Correlation Least Mean Squares) algorithm in consideration of the double talk problem. The convergence speed of the proposed method is improved by using Gram‐Schmidt orthogonalization for the input signal. © 2007 Wiley Periodicals, Inc. Electr Eng Jpn, 161(2): 42– 51, 2007; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/eej.20369