bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radiomics analysis of R2* maps to predict early recurrence of single hepatocellular carcinoma after hepatectomy
Authors: Li Jia , Ma Yunhui , Yang Chunyu , Qiu Ganbin , Chen Jingmu , Tan Xiaoliang , Zhao Yue 
Published: February 2024

ObjectivesThis study aimed to evaluate the effectiveness of radiomics analysis with R2* maps in predicting early recurrence (ER) in single hepatocellular carcinoma (HCC) following partial hepatectomy.MethodsWe conducted a retrospective analysis involving 202 patients with surgically confirmed single HCC having undergone preoperative magnetic resonance imaging between 2018 and 2021 at two different institutions. 126 patients from Institution 1 were assigned to the training set, and 76 patients from Institution 2 were assigned to the validation set. A least absolute shrinkage and selection operator (LASSO) regularization was conducted to operate a logistic regression, then features were identified to construct a radiomic score (Rad-score). Uni- and multi-variable tests were used to assess the correlations of clinicopathological features and Rad-score with ER. We then established a combined model encompassing the optimal Rad-score and clinical-pathological risk factors. Additionally, we formulated and validated a predictive nomogram for predicting ER in HCC. The nomogram’s discrimination, calibration, and clinical utility were thoroughly evaluated.ResultsMultivariable logistic regression revealed the Rad-score, microvascular invasion (MVI), and α fetoprotein (AFP) level &gt; 400 ng/mL as significant independent predictors of ER in HCC. We constructed a nomogram based on these significant factors. The areas under the receiver operator characteristic curve of the nomogram and precision-recall curve were 0.901 and 0.753, respectively, with an F1 score of 0.831 in the training set. These values in the validation set were 0.827, 0.659, and 0.808.ConclusionThe nomogram that integrates the radiomic score, MVI, and AFP demonstrates high predictive efficacy for estimating the risk of ER in HCC. It facilitates personalized risk classification and therapeutic decision-making for HCC patients.
Overexpression of circulating CD38+ NK cells in colorectal cancer was associated with lymph node metastasis and poor prognosis
Authors: Wang Xueling , Li Haoran , Chen Huixian , Fang Kehua , Chang Xiaotian 
Published: February 2024

IntroductionLymph node metastasis (LNM) is a critical prognostic factor for colorectal cancer (CRC). Due to the potential influence of immune system on CRC progression, investigation into lymphocyte subsets as clinical markers has gained attention. The objective of this study was to assess the capability of lymphocyte subsets in evaluating the lymph node status and prognosis of CRC.MethodsLymphocyte subsets, including T cells (CD3+), natural killer cells (NK, CD3- CD56+), natural killer-like T cells (NK-like T, CD3+ CD56+), CD38+ NK cells (CD3- CD56+ CD38+) and CD38+ NK-like T cells (CD3+ CD56+ CD38+), were detected by flow cytometry. Univariate and multivariate analyses were used to assess the risk factors of LNM. The prognostic role of parameters was evaluated by survival analysis.ResultsThe proportion of CD38+ NK cells within the NK cell population was significantly higher in LNM-positive patients (p &lt;0.0001). However, no significant differences were observed in the proportions of other lymphocyte subsets. Poorer histologic grade (odds ratio [OR] =4.76, p =0.03), lymphovascular invasion (LVI) (OR =22.38, p &lt;0.01), and CD38+ NK cells (high) (OR =4.54, p &lt;0.01) were identified as independent risk factors for LNM. Furthermore, high proportion of CD38+ NK cells was associated with poor prognosis of CRC patients (HR=2.37, p =0.03).ConclusionsIt was demonstrated that the proportion of CD38+ NK cells was a marker overexpressed in LNM-positive patients compared with LNM-negative patients. Moreover, an elevated proportion of CD38+ NK cells is a risk factor for LNM and poor prognosis in CRC.
Access to advanced healthcare services and its associated factors among patients with cervical cancer in Addis Ababa, Ethiopia
Authors: Shimels Tariku , Gashawbeza Biruck , Gedif Fenta Teferi 
Published: February 2024

ObjectiveThis study aimed to assess the extent of access to healthcare services, perception and associated factors among patients with cervical cancer in Addis Ababa, Ethiopia.MethodsA facility-based cross-sectional study was conducted from 01 July through 30 August 2023 at two tertiary hospitals. Cases with histopathologic and clinical confirmation of cervical cancer were enrolled using a consecutive sampling technique. Data was collected through a validated questionnaire administered by interviewers using the KoboCollect application. Subsequently, the collected data underwent analysis using Statistical Sciences for Social Sciences (SPSS) version 26.0. Bivariable and multivariable regression models were performed at p ≤ 0.2 and p&lt;0.05 statistical significance, respectively.ResultsA total of 391 patients were enrolled in the study. Health facilities were accessible for obtaining general medical services (56.5%), drugs (57.3%), laboratory diagnosis services (57.0%), imaging diagnosis services (56.8%), and radiotherapy services (55.8%) of the patients. Cost of services was affordable only in 11.5% of the cases. Essential anticancer medicines were out of stock for 229 (58.6%) of the patients during the past three months. About two-thirds of the patients have a good perception of access to healthcare services. In multivariable binary logistic regression, admission to the inpatient (AOR: 0.20, 95% CI: 0.06-0.67), joblessness (AOR: 0.19, 95% CI: 0.08-0.46), lower level of income to the extreme poverty line (3567ETB)(64.9 USD) (AOR: 0.19, 95% CI: 0.10-0.35), no CBHI coverage (AOR: 4.16, 95% CI: 1.76-9.85), having social support (AOR: 3.80; 95% CI: 1.96-7.41), and poor dietary practice (AOR: 2.36, 95% CI: 1.28-4.35) were found to have a statistically significant association with perceived good access to healthcare services.ConclusionOnly close to a half of the patients with cervical cancer, in Addis Ababa, have adequate access to healthcare services. Nearly two-thirds of the patients reported perceived good access to the services. Many factors were found to show a statistically significant association with patients’ perceived access to healthcare services.
Real-time and lightweight detection of grape diseases based on Fusion Transformer YOLO
Authors: Liu Yifan , Yu Qiudong , Geng Shuze 
Published: February 2024

IntroductionGrapes are prone to various diseases throughout their growth cycle, and the failure to promptly control these diseases can result in reduced production and even complete crop failure. Therefore, effective disease control is essential for maximizing grape yield. Accurate disease identification plays a crucial role in this process. In this paper, we proposed a real-time and lightweight detection model called Fusion Transformer YOLO for 4 grape diseases detection. The primary source of the dataset comprises RGB images acquired from plantations situated in North China.MethodsFirstly, we introduce a lightweight high-performance VoVNet, which utilizes ghost convolutions and learnable downsampling layer. This backbone is further improved by integrating effective squeeze and excitation blocks and residual connections to the OSA module. These enhancements contribute to improved detection accuracy while maintaining a lightweight network. Secondly, an improved dual-flow PAN+FPN structure with Real-time Transformer is adopted in the neck component, by incorporating 2D position embedding and a single-scale Transformer Encoder into the last feature map. This modification enables real-time performance and improved accuracy in detecting small targets. Finally, we adopt the Decoupled Head based on the improved Task Aligned Predictor in the head component, which balances accuracy and speed.ResultsExperimental results demonstrate that FTR-YOLO achieves the high performance across various evaluation metrics, with a mean Average Precision (mAP) of 90.67%, a Frames Per Second (FPS) of 44, and a parameter size of 24.5M.ConclusionThe FTR-YOLO presented in this paper provides a real-time and lightweight solution for the detection of grape diseases. This model effectively assists farmers in detecting grape diseases.
Efficacy of music therapy on stress and anxiety prior to dental treatment: a systematic review and meta-analysis of randomized clinical trials
Authors: López-Valverde Nansi , López-Valverde Antonio , Macedo de Sousa Bruno , Blanco Rueda José Antonio 
Published: February 2024

IntroductionStress and anxiety are emotional states that often accompany patients who have to receive dental treatments, leading them to postpone or avoid treatments with the consequent deterioration of their oral health and, hence, their general condition. Music therapy has been shown to be an alternative to other treatments that are invasive and not without danger, such as anxiolytics or sedation. This systematic review and meta-analysis evaluated the effect of music therapy on anxiety and stress prior to dental treatments.MethodsStudies published in PubMed (through Medline), Web of Science (WOS), Embase, and Cochrane Library databases were consulted up to October 2023. The inclusion criteria were established for intervention studies (randomized controlled trials, RCTs) according to the PICOS (population, intervention, comparison, outcomes, and study) strategy in subjects with dental stress and anxiety (participants) treated with music therapy (intervention) in comparison with patients without music therapy (control) and evaluating the response to treatment (outcomes).ResultsA total of 154 results were obtained, with 14 studies finally selected. The risk of bias and the methodological quality were assessed using the Cochrane Risk of Bias Tool and the Jadad scale, respectively. A random-effects meta-analysis was used to quantify the results of the pooled studies, while a fixed-effects meta-analysis was used for studies in the pediatric population. The meta-analysis of pooled studies found statistical significance in the subgroups of anxiety and anxiety–stress (p = 0.03 and p = 0.05, respectively), with an overall effect in favor of the intervention group (p = 0.005). Meta-analysis of the studies in the pediatric population showed considerable statistical significance for the experimental group (p &lt; 0.00001).ConclusionMusic therapy as a treatment for stress and anxiety, prior to dental treatment, proved to be effective in both children and adults although more well-designed randomized clinical studies are needed to validate its efficacy.Systematic review registrationINPLASY, identifier 202312000.
Return to work, work productivity loss and activity impairment in Chinese breast cancer survivors 12-month post-surgery: a longitudinal study
Authors: Ng Danielle Wing Lam , So Serana Chun Yee , Fielding Richard , Mehnert-Theuerkauf Anja , Kwong Ava , Suen Dacita , Wong Ling , Fung Sara Wai Wun , Chun Oi Kwan , Fong Daniel Y. T. , Chan Sharon , Molasiotis Alex , So Winnie K. W. , Lam Wendy Wing Tak 
Published: February 2024

IntroductionExisting evidence of returning-to-work (RTW) after cancer comes predominately from Western settings, with none prospectively examined since the initial diagnostic phase. This study prospectively documents RTW-rate, time-to-RTW, work productivity loss, and activity impairment, within the first-year post-surgery among Chinese women with breast cancer (BCW) and identify potential causal co-variants.MethodsThis observational longitudinal study followed 371 Chinese BCW who were employed/self-employed at the time of diagnosis at 4-week post-surgery (baseline). RTW-status and time-to-RTW were assessed at baseline (T1), 4-month (T2), 6-month (T3), and 12-month (T4) post-baseline. WPAI work productivity loss and activity impairment were assessed at T4. Baseline covariates included demographics, medical-related factors, work satisfaction, perceived work demand, work condition, RTW self-efficacy, B-IPQ illness perception, COST financial well-being, EORTC QLQ-C30 and QLQ-BR23 physical and psychosocial functioning, and HADS psychological distress.ResultsA 68.2% RTW-rate (at 12-month post-surgery), prolonged delay in RTW (median = 183 days), and significant proportions of T4 work productivity loss (20%), and activity impairment (26%), were seen. BCW who were blue-collar workers with lower household income, poorer financial well-being, lower RTW self-efficacy, poorer job satisfaction, poorer illness perception, greater physical symptom distress, impaired physical functioning, and unfavorable work conditions were more likely to experience undesired work-related outcomes.DiscussionUsing a multifactorial approach, effective RTW interventions should focus on not only symptom management, but also to address psychosocial and work-environmental concerns. An organizational or policy level intervention involving a multidisciplinary team comprising nurses, psychologists, occupational health professionals, and relevant stakeholders in the workplace might be helpful in developing a tailored organizational policy promoting work-related outcomes in BCW.
Development of a Cognitive Training Support Programme for prevention of dementia and cognitive decline in at-risk older adults
Authors: de Jager Loots Celeste A. , Price Geraint , Barbera Mariagnese , Neely Anna Stigsdotter , Gavelin Hanna M. , Lehtisalo Jenni , Ngandu Tiia , Solomon Alina , Mangialasche Francesca , Kivipelto Miia 
Published: February 2024

BackgroundEvidence for the beneficial effects of cognitive training on cognitive function and daily living activities is inconclusive. Variable study quality and design does not allow for robust comparisons/meta-analyses of different cognitive training programmes. Fairly low adherence to extended cognitive training interventions in clinical trials has been reported.AimsThe aim of further developing a Cognitive Training Support Programme (CTSP) is to supplement the Computerised Cognitive Training (CCT) intervention component of the multimodal Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER), which is adapted to different cultural, regional and economic settings within the Word-Wide FINGERS (WW-FINGERS) Network. The main objectives are to improve adherence to cognitive training through a behaviour change framework and provide information about cognitive stimulation, social engagement and lifestyle risk factors for dementia.MethodsSix CTSP sessions were re-designed covering topics including (1) CCT instructions and tasks, (2) Cognitive domains: episodic memory, executive function and processing speed, (3) Successful ageing and compensatory strategies, (4) Cognitive stimulation and engagement, (5) Wellbeing factors affecting cognition (e.g., sleep and mood), (6) Sensory factors. Session content will be related to everyday life, with participant reflection and behaviour change techniques incorporated, e.g., strategies, goal-setting, active planning to enhance motivation, and adherence to the CCT and in relevant lifestyle changes.ConclusionsThrough interactive presentations promoting brain health, the programme provides for personal reflection that may enhance capability, opportunity and motivation for behaviour change. This will support adherence to the CCT within multidomain intervention trials. Efficacy of the programme will be evaluated through participant feedback and adherence metrics.
Longitudinal changes in habitual physical activity in adult people with cystic fibrosis in the presence or absence of treatment with elexacaftor/tezacaftor/ivacaftor
Authors: Gruber Wolfgang , Stehling Florian , Blosch Christopher , Dillenhoefer Stefanie , Olivier Margarete , Brinkmann Folke , Koerner-Rettberg Cordula , Sutharsan Sivagurunathan , Mellies Uwe , Taube Christian , Welsner Matthias 
Published: February 2024

BackgroundHabitual physical activity (PA) and exercise training are accepted as important aspects of care for people with cystic fibrosis (pwCF) to improve health-related measures of physical fitness, which in turn have a positive impact on quality of life and prognosis. In the last decade, effective CFTR modulator therapies have become a promising treatment for pwCF by targeting the underlying cause of CF. This highly effective therapy improves clinical outcomes and quality of life in people with specific CFTR mutations. Little is known about the longitudinal pattern of PA or the impact of the highly effective modulator therapy with Elexacaftor/Tezacaftor/Ivacaftor (ETI) on PA in adult pwCF. This study assessed the course of device-based PA measurement in adult pwCF and evaluated the effects of ETI on habitual physical activity in those who were eligible for ETI.MethodsData from adult pwCF (aged ≥18 years) were analysed at baseline and follow-up, using identical assessments at both time points. Outcome parameters were PA in steps/day and the intensity of PA. The group that received ETI was treated for an average of 33 weeks and not for the entire duration of the period. The data were collected between 2021 and 2022, following the removal of absolute pandemic restrictions/lockdowns.ResultsFollow-up duration was 5.6 years in pwCF with ETI (ETI group, n = 21) and 6.5 years in pwCF without ETI (non-ETI group, n = 6). From baseline to follow-up, pwCF treated with ETI had a significant increase in steps/day (+25%, p = 0.019) and a non-significant increase in moderate-to-vigorous intensity time (+5.6%, p = 0.352). Conversely, individuals in the non-ETI group showed a non-significant decrease in both steps/day −3.2%, p = 0.893) and moderate-to-vigorous intensity time (−25%, p = 0.207). The ETI group showed a significant decrease in percent predicted forced expiratory volume in 1 s (ppFEV1) and FEV1 z-score before the start of ETI treatment, both of which improved significantly after therapy initiation. Body weight and body mass index also improved significantly with ETI use.ConclusionsThese data suggest that ETI treatment has a positive effect on habitual physical activity behavior in the adult pwCF studied.
The Most Important Indicators of Microbiota of Oncological Patients and their Changing after Surgical and Conservative Treatment
Authors: Джавадзаде С.H. 
Published: February 2024

Статья посвящена пpоблеме шиpокого pаспpостpанения втоpичных инфекций сpеди онкологических пациентов (ОП). Автоpы пpедставили pезультаты бактеpиологического и микологического исследования матеpиалов, полученных у 705 ОП, получавших лечение в отделениях Hационального центpа онкологии в г. Баку. Из них 255 ОП находились в отделениях хиpуpгического пpофиля и 450 ОП – в отделениях теpапевтического пpофиля. Показано, что по pяду показателей микpобиота у ОП имела значительное сходство с микpофлоpой, обнаpуженной на объектах окpужающей сpеды в пpеделах Hационального центpа онкологии. Лечение ОП заметно влияло на показатели микpобиоты этих пациентов. Так, после хиpуpгических опеpаций отмечалось относительное уменьшение числа выявленных штаммов как бактеpий, так и гpибов. После химиотеpапии отмечалось изменение таксономического спектpа микpобиоты и частоты выявления pазличных бактеpиальных и гpибковых агентов.
The paper dedicated to problem of secondary infections wide spreadingamong oncological patients (OP). Authors presented results of bacteriological and mycological investigations of materials obtained from 705 OP, staid in department of the National center of oncology in Baki. 255 of these OP were in departments of surgical prophile and 450 of OP were in departments of therapeutic profile. It was demonstrated that several indicators of OP microbiota have significant similarity with microflora detected on environmental objects existed inside National center of oncology. Treatment significantly influenced to some indicators of microbiota of OP. Thus, after surgical operation it was detected relatively decrease detected strains of bacteria and fungi. After chemotherapy, it was detected changing of taxonomicalspectrum and frequencies of detection different species of bacteria and fungi.
Predictive Value of Expression of Survivin mRNA (BIRC5) in Bowel Cancer in Circulating Tumour Cells
Authors: Орехва А.В. , Шляхтунов Е.А. , Семёнов В.М. , Жильцов И.В. , Карчмит Е.В. , Шаппо Г.М. , Лях Я.Н. , Орехва А В. 
Published: February 2024

Впервые изучена клиническая значимость экспрессии мРНК сурвивина (BIRC5) в циркулирующих опухолевых клетках у пациентов, страдающих колоректальным раком. Установлено, что сурвивин является высокочувствительным опухолевым маркером при колоректальном раке ввиду гиперэкспрессии в циркулирующих опухолевых клетках, что является негативным фактором прогноза заболевания и напрямую зависит от опухолевого поражения регионарных лимфоузлов, стадии заболевания, степени дифференцировки опухоли, размеров опухоли. Определение экспрессии сурвивина в циркулирующих опухолевых клетках через 9 месяцев после радикальной операции может использоваться для диагностики минимальной остаточной болезни и оценки прогноза общей выживаемости.
For the first time, the clinical significance of survivin (BIRC5) mRNA expression in circulating tumor cells in patients with colorectal cancer was studied. It has been established that survivin is a highly sensitive tumor marker in colorectal cancer, due to overexpression in circulating tumor cells, which is a negative prognostic factor for the disease and directly depends on the tumor lesion of regional lymph nodes, the stage of the disease, the degree of tumor differentiation, and tumor size. Determination of survivin expression in circulating tumor cells 9 months after radical surgery can be used to diagnose minimal residual disease and assess the prognosis of overall survival rate.
Development of nanostructured Ge/C anodes with a multistacking layer fabricated via Ar high-pressure sputtering for high-capacity Li+-ion batteries
Authors: Omae Tomoki , Yamada Teruya , Fujikake Daiki , Kozawa Takahiro , Uchida Giichiro 
Published: February 2024

Abstract
To realize high-capacity Ge anodes for next-generation Li+-ion batteries, a multilayer anode with a C(top)/Ge(middle)/C(bottom) structure was developed, where nanostructured amorphous Ge (a-Ge) and amorphous-like carbon films with a grain size of 10–20 nm were deposited sequentially by high-pressure Ar sputtering at 500 mTorr. Compared with the a-Ge anode, the C(top)/a-Ge(middle)/C(bottom) multistacking layer anode showed improved capacity degradation for repeated lithiation/delithiation reactions and achieved a high capacity of 910 mAh g−1 with no capacity fading after 90 cycles at a C-rate of 0.1.
PERBANDINGAN KINERJA REKSA DANA SAHAM KONVENSIONAL DENGAN REKSA DANA SAHAM SYARIAH DENGAN METODE INDEKS SHARPE, INDEKS TREYNOR, DAN ALPHA JENSEN YANG DILAKUKAN PADA PERIODE PANDEMI COVID-19.
Authors: Ella Anggraini  , Asep Risman  
Published: February 2024

Abstrak
Selama era pandemi Covid-19, harga saham mempengaruhi fluktuasi secara derastis, pemahaman tentang analisa kinerja reksa dana saham ini, dapat membantu investor dalam pengambilan keputusan investasi yang lebih baik lagi. Tujuan penelitian ini untuk membandingkan kedua kinerja reksa dana saham yaitu reksa dana saham Syariah dan reksa dana saham Konvensional dengan menggunakan metode analisis Indeks Sharpe, Indeks Treynor, dan Alpha Jensen. Hasil penelitian menunjukkan Manulife Saham Andalan sebagai reksa dana konvensional terbaik dan Sucorinvest Sharia Equity sebagai reksa dana syariah terbaik. Selain itu, Hasil uji independen sample t-test menunjukkan bahwa metode Sharpe dan Treynor tidak memiliki perbedaan antara reksa dana saham syariah dan reksa dana saham konvensional (H0 diterima), sementara metode Jensen memiliki perbedaan signifikan (H0 ditolak). Namun dari rata-rata kinerja, reksa dana saham konvensional lebih unggul dibandingkan dengan reksa dana syariah.