bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exaggerated cold‐pressor response in hypertensive patients with superimposed arteriosclerosis
Authors: Voudoukis Ignatios J. 
Published: February 2007

AbstractA series of 172 hypertensive patients with excessive cold‐pressor response (elevation of systolic blood pressure more than 30 mm Hg above basal) and 65 hypertensive patients with normal cold‐pressor response (elevation of systolic blood pressure less than 20 mm Hg above basal) was studied. A correlation of the pressor response with various parameters pertaining to the cardiovascular system was made. A highly significant correlation between retinal arteriosclerosis and exaggerated cold‐pressor response was seen. In addition, there was an excellent correlation between the latter and calcification of the aorta and/or its branches. Arteriosclerotic heart disease was much more prevalent among the hyperreactors than among the normoreactors. Elevation in serum cholesterol was also more frequent in the hyperreactors, but it was only seen in a small percentage of cases. The incidence of diabetes mellitus and established diastolic hypertension was also higher in the hyperreactors than in the normoreactors. Obesity was found twice as often in the patients with excessive cold‐pressor response than with normal cold‐pressor response. The results would seem to suggest that exaggerated cold‐pressor response may be related to superimposed systemic vascular sclerosis rather than to hypertension per se.
Supravesical urinary diversion: A comparison between cutaneous ureterostomy and heal conduit
Authors: Kursh Elroy D. , Albert David J. , Persky Lester 
Published: February 2007

AbstractIn an effort to compare objectively the two most commonly employed methods of supravesical urinary diversion, the cutaneous ureterostomy and the ileal conduit, this study was designed to compare functionally each technique in the experimental animal. Sixteen female mongrel dogs underwent ligation of the distal right ureter. One week later, diversion of the right ureter was performed by either cutaneous ureterostomy or ileal conduit in two groups of animals. One month following diversion, the function of the diverted right kidney was compared to the control left kidney in all dogs and radiological evaluation was done. In the groups of dogs diverted by the ileal conduit, renal function studies were significantly better and radiologic interpretation revealed a more nearly normal collecting system. The data strongly support the position that the ileal conduit is the preferred route for urinary diversion in the dog. The clinical application is discussed.
Value of electrophysiologic tests for peripheral nerve neuromas
Authors: Kline David G. , Hackett Earl R. 
Published: February 2007

AbstractManagement of a peripheral nerve neuroma can be improved by the use of electro‐physiologic tests. The relative value of these tests and their possible applications are discussed in some detail. Nerve stimulation either preoperatively or at the operating table remains the simplest and best test for early regeneration. Electromyography can document denervation, although similar conclusions can usually be reached by a careful clinical examination. Nascent muscle action potentials or decreased numbers of fibrillations can be recorded by electromyography and sometimes herald return of function. Conduction velocity tests are most useful for neuropathies of nontraumatic origin, while muscle stimulation tests are of limited value because they tell the investigator little about the quantity or quality of reinnervation. Evoked nerve action potentials (NAP) can be recorded at the operating table and are helpful in documenting a partial lesion or relatively early regeneration.
Free urinary amino acid excretion in patients with familial polyposis of the colon
Authors: Sachatello Charles R. , Tritsch George 
Published: February 2007

AbstractThe free urinary amino acids excretion per 24 hr of the neutral and acidic amino acids did not reveal any diagnostic abnormality in five patients with familial polyposis of the colon with or without associated desmoid tumors and osteomas. One patient with Klinefelter's syndrome and familial polyposis had a urinary acid excretion pattern indistinguishable from his brother, who had familial polyposis and normal chromosomes. It is suggested that patients with familial polyposis deserve intensive biochemical study as this represents a prototype hereditary malignant disease.
Delayed wound closures based on bacterial counts
Authors: Robson Martin C. , Heggers John P. 
Published: February 2007

AbstractThere exists a quantitative relationship between bacterial contamination and clinical infection. Because of this relationship, delayed wound closure can be performed based on the number of viable bacteria present in the incision at the time of closure. This principle was applied to 95 delayed wound closures in a prospective series. Ninety‐three cases were closed when the bacterial estimate was 105 bacteria or fewer per gram of tissue. This resulted in a 96% successful closure rate. The method of bacterial quantification on a tissue biopsy from the wound requires 1 hr from time of culture to quantitative report to the surgeon so that closure can be effected.
The incidence of ‘leukovirus’ in cultured human hematopoietic cells
Authors: Moore George E. , Kitamura Hajime , Minowada Jim 
Published: February 2007

AbstractA majority of cell lines derived from peripheral blood samples of patients with leukemia, lymphomas, and other malignancies and of normal individuals have a herpes‐like virus (or EBV). This virus seems to be identical with one found in Burkitt lymphoma cell lines. The virus has biological activity to the extent of destroying some cells of the affected cell line, but is seemingly incapable of infecting some noninfected cell lines. No strong evidence of alteration of biological activity of the cells or their chromosomes by leukovirus was noted.
An evaluation of the mechanism of action of pentamidine isethionate
Authors: Bornstein Richard S. , Yarbro J. W. 
Published: February 2007

AbstractThe effect of pentamidine on DNA, RNA, phospholipid, and protein synthesis was evaluated in 6C3HED ascites tumor of C3H mice by incorporation in vitro of 3H‐thymidine, 3H‐uridine, 3H‐algal protein hydrolysate, and 32P‐orthophosphate. Inhibition of all parameters measured was observed, suggesting that pentamidine does not, as has been suggested, selectively inhibit DNA synthesis or act as an antifol. A reduced incorporation of 32P into charcoal adsorbable acid soluble phosphate was observed, suggesting that pentamidine may impair nucleotide formation.
The radioisotope skeletal survey
Authors: Volpe Joseph A. 
Published: February 2007

AbstractThe radionuclides presently available for bone imaging include Sr87m, Sr85, and F18. With any of these, the entire skeleton can be surveyed for localized bone disease by profile scanning, whole body counting, rectilinear scanning, or with the Mark II whole body scanner and positron scintillation camera. Whole body counting and profile scanning rapidly eliminate normal areas and focus attention on suspicious sites which must then be studied with a conventional scantier. Rectilinear scanning requires considerable time. The Mark II whole body scanner can survey the skeleton rapidly but not so accurately as the positron scintillation camera. The positron camera is accurate but slow. The ideal method for accurately and rapidly surveying the entire skeleton would utilize F18 as the radioactive agent and a large‐crystal positron scintillation camera as the imaging device.
Tissue adhesives and pelvic hemostasis: An evaluation of isobutyl 2‐cyanoacrylate
Authors: O'Leary James A. 
Published: February 2007

AbstractA tissue adhesive, isobutyl cyanoacrylate, was studied in 17 mongrel dogs. The hemostatic properties of the drug were good, but the tissue tensile strength was inadequate. The exothermic activity of the preparation caused some tissue distortion. The aerosol study group was associated with an increase in sepsis. The clinical usefulnesses of the preparation are numerous and remain to be explored.
Variation in tumor doubling time in patients with pulmonary metastatic disease
Authors: Joseph William L. , Morton Donald L. , Adkins Paul C. 
Published: February 2007

AbstractRecent experience has shown that the tumor doubling time (TDT) is an easily measurable, uniform, and accurate method for judging the progression of pulmonary metastatic disease in patients. Forty‐five patients with multiple pulmonary metastatic foci present had their TDTs measured. In 37, the calculated TDTs for each individual were similar and allowed the patients to be placed in particular groups based on their growth rates. In eight patients, there was particularly wide variation in TDTs such that placement of these patients into a particular category was impossible. Prognosis in these individuals appeared to be determined by the more rapid TDT. Nevertheless, in the majority of instances, calculated TDTs appear to be similar in each patient, and this confirms the accuracy of measurement of TDT in patients with multiple metastatic foci. Reasons for the wide variations in TDTs seen in some patients are suggested.
The metabolism and pharmacology of 5‐fluorouracil
Authors: Miller Edward 
Published: February 2007

Abstract5‐Fluorouracil (5‐FU) is a chemotherapeutic agent, which is administered systemically for the palliative treatment of certain neoplastic diseases. Because 5‐FU is a potent antimetabolite, it is recommended that the drug be given only by physicians experienced in the use of antimetabolites. Now that 5‐FU is being applied topically for the treatment of skin neoplasms, it would be useful to review the metabolism and pharmacology of this compound. In this paper, the metabolic pathways, the antineoplastic mechanism of action, and the effects on normal tissues are discussed.
Occurrence of simian virus 40 (SV40)‐reacting antibodies in sera of some patients with prostatic cancer
Authors: Shah K. V. , Weismann M. , Murphy G. P. 
Published: February 2007

AbstractSV48‐neutralizing antibodies were found in four of 77 sera from patients with pgostatic carcinoma. T antibodies were not detected in any of the sera. The antibody prevalence and the titers of positive sera in prostatic cancer patients were similar to those in sera of bladder cancer patients and of non‐cancerous individuals.
Gardner's syndrome, colon cancer, and sarcoma
Authors: Johnson Jerome G. , Gilbert Enid , Zimmermann Bernard , Watne Alvin L. 
Published: February 2007

AbstractSoft tissue involvement is a major component of Gardner's syndrome. While these are frequently skin inclusion cysts, some patients exhibit fibrous dysplasias. These can vary from severe fibrosis, frequently intra‐abdominal and causing bowel obstruction, to desmoid tumors and fibrosarcomas, both of which can be progressive and life threatening. This aspect of the syndrome is poorly understood, but must be carefully evaluated in selecting treatment for the associated polyposis coli.
Radiotherapy in advanced prostatic carcinoma
Authors: Varkarakis M. J. , Webster J. , Bhanalaph T. , Murphy G. P. 
Published: February 2007

AbstractTwenty‐two patients with advanced stages of prostatic carcinoma were treated with‐Cobalt‐60 teletherapy. Local control of the prostatic lesion was obtained in five out of eight patients with stage C. and in 2 out of 14 patients with stage D of the disease. However, survival of these irradiated patients was not better than other similar patients treated with orchiectomy and stilbestrol. Following radiotherapy, pain relief was obtained in almost all the patients without serious complications. Nevertheless in available post mortem material the histological appearance of the primary tumor was unchanged before and after radiotherapy. A randomized controlled clinical trial of radiotherapy in prostatic cancer is needed before final decisions can be made on its primary role in the treatement of this disease.
The management of patients with gestational trophoblastic neoplasia based on the antigenic properties of human chorionic gonadotropin
Authors: Goldstein Donald P. , Nudemberg Franklin , Lymeburner Nancy , Levesque Linda , Shore Christine 
Published: February 2007

AbstractThe use of a rapid, solid‐phase RIA for the quantitative measurement of serum LH‐HCG activity is described for use in the management of patients with GTN. The five‐hour test period permits more precise monitoring of drug therapy without compromising therapeutic effectiveness. The future implications of this new method in redesigning therapeutic regimens according to tumor cell kinetics is discussed.
Hemangioendothelioma of the penis with late appearing metastases: Report of a case with review of the literature
Authors: Deutsch Melvin , Leen Raymond L. S. , Mercado Raul 
Published: February 2007

AbstractA case of hemangioendothelioma of the penis is presented. It was treated initially by excision and postoperative irradiation to the primary site. Systemic chemotherapy and radiotherapy to the thoracic spine was administered in the belief that the patient had osseous metastases in the spine. The patient was subsequently free of disease for more than five years at which time metastases appeared almost simultaneously in the extradural spinal column, right 12th rib, and lungs. A possible explanation for the peculiar distribution of these metastases is presented.A review of the literature reveals no more than 30 other cases, none of which showed a similar clinical course, namely later appearing metastases after a five‐year disease‐free interval.
Fudr as an adjuvant to surgery in cancer of the large bowel
Authors: Dwight Richard W. , Humphrey Edward W. , Higgins George A. , Keehn Robert J. 
Published: February 2007

AbstractIn a controlled trial the Veterans Administration Surgical Adjuvant Group studied 735 patients with carcinoma of the large bowel in an effort to determine the possible benefits of using FUDR as an adjuvant to surgical resection. Patients randomized to treatment received a reduced course of the drug on the first, second, and third postoperative days, and a second standard therapeutic course approximately six weeks later. There was no significant difference in postoperative complications or 30 day mortality. The second course of chemotherapy was an apparent contributory factor in the death of six patients. Long term follow‐up studies showed no difference in survival between patients receiving the drug and those treated by surgery alone.
Serum lactic dehydrogenase and isoenzyme changes in clinical cancer
Authors: Wood Don C. , Varela Virginia , Palmquist Michele , Weber Frank 
Published: February 2007

AbstractTotal LDH and LDH isoenzyme values were measured in serum collected from patients at the time of hospital admission. Changes in isoenzyme values were not necessarily found to depend upon elevated total serum LDH levels. Many patients with normal levels of serum LDH had abnormal isoenzyme patterns usually related to a disease process. A large percentage of patients with neoplastic disease had statistically increased LDH 5 values. Many other patients with either acute and/or chronic disease failed to reflect changes in the isoenzyme values.
Esophageal cancer in california 1942‐1969: The California tumor registry experience
Authors: Krain Lawrence Stirling 
Published: February 2007

AbstractAn analysis of the 3,319 cases of esophageal cancer (ICD No. 150), 1942‐1969, from the California Tumor Registry was performed, and related data are examined. Esophageal cancer predominates in the Negro race, urban areas in California, and the lower socio‐economic classes. Esophageal cancer occurs at a median age of 63.8 years and has a male‐female sex ratio of 2.84:1. Despite an increase in the percentage of cases localized at the time of diagnosis, the five‐year survival rate (localized cases) for esophageal cancer patients has remained constant at 7%. The mean survival from the time of diagnosis for all stages of the disease was 5.2 months. Although there has been a slight increase in incidence of esophageal cancer, the mortality rate has remained constant at 2.4/100,000 (age‐adjusted). While more patients have been treated with surgery and/or radiation, this has had a negligible effect on the relative survival rates for esophageal cancer.
Cross‐classification and survival characteristics of 5,000 cases of cancer of the pancreas
Authors: Baylor Stephen M. , Berg John W. 
Published: February 2007

AbstractOver 5,000 histologically confirmed cases of cancer of the pancreas from the End Results Group of cancer registries have been examined for differences in behavior by epidemiologic and pathologic variables. Thirteen percent had a specific histologic diagnosis other than “adenocarcinoma,” “carcinoma,” or “cancer.” The 92 cases of islet cell carcinoma were unique, having a much younger age at diagnosis (two‐thirds instead of one‐third diagnosed under the age of 60), a locational preference for the body and/or tail (only 40% instead of 70% occurring in the head of the pancreas), and a very favorable survival experience (15 year relative survival of 14%). Of cancers of the exocrine pancreas, the 64 cases with papillary histology were most distinct, two‐thirds being found in women, 18% instead of 10% being localized, and having relatively favorable survival (30% one‐year survival, 5% three‐year survival). Patients whose tumors revealed squamous metaplasia occurred in general at older ages and had unusually poor survival. Analysis by anatomic location showed an increasing percentage of carcinomas occurring in the head of the pancreas with increasing age. Analysis of “adenocarcinomas” by histologic grade indicated that grade may carry some prognostic information not explained by difference in stage. A striking gradient of decreasing survival with increasing age did not explain, and was not explained by survival gradients in other variables.
Control of erythropoietin production during hypoxic hypoxia
Authors: Harvey S. R. , Mirand E. A. , Back N. , Murphy G. P. 
Published: February 2007

AbstractThe control of erythropoietin (ESF) production in rats subjected to hypoxic hypoxia was investigated by studying the inhibition of endogenous ESF production by inhibitors affecting proteases and protein synthesis. The study revealed that the production of endogenous ESF was inhibited by protease inhibitors, Trasylol and epsilon amino caproic acid (EACA) and inhibitors affecting protein synthesis such as actinomycin–D, puromycin, and cycloheximide. The inhibitory effect of actinomycin–D on ESF production was dose dependent and markedly dimiished (threefold) in hepatectomized rats, whereas the inhibitory effects of Trasylol, EACA, and Step–I ESF (used as feedback inhibitor) were enhanced. These preliminary findings suggest that, during hypoxic stress, the control of ESF production may involve the interaction of a protease‐globulin substrate to produce ESF as well as the de novo synthesis of a protein or proteins involved in ESF production.
Extracranial meningioma
Authors: Farr Hollon W. , Gray George F. , Vrana Mark , Panio Michael 
Published: February 2007

AbstractMeningioma can be a diagnostic problem for the head and neck surgeon and the surgical pathologist by reason of extracranial manifestation and the varying histological patterns seen in small biopsy specimens submitted from various extracranial sites. During the thirty year period 1940–1970, 405 cases of meningioma were seen at the New York Hospital and the Memorial Hospital and the clinical findings have been reviewed together with recent pertinent literature. Thirty‐four cases were spinal in origin: 9 cervical, 22 dorsal, and 2 lumbar. An external mass was present in 20% of the intracranial tumors: the orbit was involved in 30 patients, the outer table and scalp in 25, the paranasal sinuses and nasal cavity in 10, and the parotid and parapharyngeal region in 5. Three cases are documented primary extracranial meningiomas arising is soft parts; one free in the orbit and two in the neck masquerading as deep lobe parotid gland tumors. The pathological features of extra‐cranial meningioma were identical with the intracranial variety and a standard classification of the main histological types is outlined. A variety of differential diagnoses were entertained before the true nature of the neoplasm was established. The necessity for sophisticated radiographic studies and neurosurgical attention to the intracranial component of the tumor is emphasized.
Effect of adrenal cortical steroids on liver regeneration
Authors: Gershbein Leon L. 
Published: February 2007

AbstractRats were partially hepatectomized, injected sc daily for the first 7 days with oil solutions of several mineralo‐ and glucocorticoids, sacrificed on the tenth post‐operative day, and the extent of liver regeneration ascertained. Cortisone and prednisolone acetates at overall levels of 70 and 7.5 mg/kg, respectively, depressed regeneration, as was also noted with aqueous solutions of hydrocortisone and dexamethasone sodium phosphates at about 85 and 0.7 mg/kg, in the order stated; aldosterone (0.5 mg/kg) or fludrocortisone (15 mg/kg) were ineffective. The injection of deoxycorticosterone acetate (130 mg/kg) or the feeding of a diet with spironolactone supplemented at 0.060% accelerated liver regeneration and these, in addition to very massive levels of progesterone, counteracted the effect of cortisone; testosterone propionate negated the action of the latter in the adult female. An inhibitory response was also evident when cortisone acetate was fed at 50 ppm. The extent of regeneration was little affected in rats adrenalectomized at least 5 days prior to partial hepatectomy and, except for dexamethasone (0.7 mg/kg), the inhibitory influence of the above glucocorticoids was minimal; the stimulatory action of spironolactone continued. In normal or adrenalectomized rats with intact liver, the spironolactone feeding and, even more so, the sc injection of fludrocortisone (15 mg/kg) elicited increases in liver‐body weight ratios, cortisone acetate at levels even as high as 190 mg/kg being without action.
Cancer of the pancreas
Authors: Kalberer John T. 
Published: February 2007

AbstractThe National Cancer Institute sponsored a one‐day workshop to discuss future plans for the study of pancreatic cancer. Ten participants discussed the limitations in progress against cancer of the pancreas and recommended studies in the areas of fundamental research, diagnosis, and treatment. They emphasized the need for coordination of clinical studies across the country, development of an early detection method, and participation of more biochemists to better define pancreatic pathophysiology.