bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immediate versus delayed implant placement of novel fully tapered tissue‐level implants – A retrospective multicenter clinical study
Authors: Schiegnitz Eik , Sagheb Keyvan , Raahimi Leila , König Jochem , Azaripour Adriano , Al‐Nawas Bilal 
Published: April 2024

AbstractObjectivesTo compare the clinical and radiological outcomes of novel fully tapered tissue‐level implants in immediate implant placement (type 1) versus late implant placement (type 4) for the first time.Materials and MethodsFor this clinical study, 318 fully tapered tissue‐level implants in 65 patients were inserted immediately (n = 68 implants) or late (n = 250 implants) in two different centers. Implant survival and success rates and marginal bone levels were analyzed.ResultsAfter a mean follow‐up of 12.0 ± 5 months, implant survival rates were 97.8% for all implants. No statistically significant difference in implant survival rates between type 1 and type 4 could be detected (98.5% vs 97.6%, HR 0.70, 95%‐CI 0.084–5.81). Neither for implant length (HR 0.53, 95%‐CI 0.055–5.08) nor for implant width (HR 0.27, CI 0.028–2.55), a significant influence on implant survival could be detected. Type of used biomaterial for filling the gap and immediate loading showed no effect on implant survival. Mean marginal bone loss was 0.02 ± 0.05 mm for type 1 and 0.04 ± 0.1 for type 4.ConclusionsWithin the limitations of this retrospective study and the short follow‐up, the results demonstrated comparable high survival and success rates and stable marginal bone levels for type 1 and type 4 placement of this novel tissue‐level implant (no clinical trial registration as retrospective study design).
Telefonische Verlaufskontrolle nach ambulanten nagelchirurgischen Eingriffen – eine retrospektive Analyse
Authors: Giordano Anna , Löser Christoph R. , Dippel Edgar , Hofmann Silke C. , Mohr Peter , Schneider Stefan W. , Balakirski Galina 
Published: April 2024

ZusammenfassungHintergrundZu den Versorgungsgebieten der Dermatochirurgie gehört die operative Behandlung von Erkrankungen des Nagelorgans. Untersucht wurden Beschwerden und Nebenwirkungen nach Nageleingriffen mittels telefonischer Verlaufskontrolle (TFU) und deren Eignung für die postoperative Kontrolle und Beratung.Patienten und MethodikAlle Patienten, die von Oktober 2019 bis Dezember 2021 in der Hautklinik am Klinikum der Stadt Ludwigshafen am Rhein ambulant am Nagelorgan operiert wurden, wurden am zweiten bis dritten postoperativen Tag telefonisch kontaktiert und standardisiert zu postoperativen Beschwerden befragt.ErgebnisseInsgesamt wurden 100 Fälle nachverfolgt. Die am häufigsten durchgeführten Eingriffe waren Phenolkaustik (41%), Nagelavulsion (16%) und Nagelmatrixbiopsien (9%). 50% und 21% der Patienten berichteten jeweils am Tag des Eingriffs und am Folgetag Schmerzen gehabt zu haben. Nach Nagelavulsion wurden signifikant häufiger Schmerzen am Folgetag nach dem Eingriff berichtet und Schmerzmittel benötigt (p = 0,002). Schwerwiegende Nebenwirkungen traten nicht auf. Zehn Prozent der Befragten äußerten bei der TFU konkrete Fragen und benötigten eine Beratung.SchlussfolgerungenAlle Nageleingriffe wurden gut vertragen. Schmerzen stellten die häufigsten Beschwerden dar, allerdings gab nur die Hälfte aller Angerufenen an, am Operationstag Schmerzen gehabt zu haben, am Folgetag nur noch 21%. Die TFU stellt eine effektive, praktikable sowie einfach zu etablierende Methode zur postoperativen Verlaufskontrolle und Beratung nach ambulanten Nageleingriffen dar.
Hydrochlorothiazid: Erhöhtes Risiko für atypisches Fibroxanthom und pleomorphes dermales Sarkom
Authors: Kuntz Thomas , Grimm Alexander , Hofmann Silke C. , Michalowitz Alena‐Lioba , Schaller Jörg , Hellmich Martin , Assaf Chalid , Oellig Frank , Kreuter Alexander 
Published: April 2024

ZusammenfassungHintergrund und ZieleBisherige Arbeiten haben gezeigt, dass Hydrochlorothiazid (HCT) aufgrund seiner photokarzinogenen Wirkung einen Risikofaktor für Plattenepithelkarzinome (SCC) und Basalzellkarzinome (BCC) darstellt. Atypische Fibroxanthome (AFX) und pleomorphe dermale Sarkome (PDS), beides UV‐induzierte Tumoren, stellen eine seltene, aber zunehmende Tumorentität der Haut dar. In dieser Studie soll untersucht werden, ob die Einnahme von HCT bei Patienten mit AFX/PDS höher ist als bei Patienten mit SCC/BCC und ob dies ein Risikofaktor für die Entwicklung von AFX/PDS sein könnte.Patienten und MethodikIn einer retrospektiven Studie an vier deutschen Hautkrebszentren wurden AFX/PDS‐Fälle und SCC/BCC‐Kontrollen über einen Zeitraum von sieben Jahren (2013‐2019) geschlechts‐ und alters‐gematcht (1:3) auf die Einnahme von HCT und immunsuppressiven Medikamenten sowie auf Zweitmalignome und Diabetes mellitus untersucht.ErgebnisseInsgesamt wurden 146 AFX/PDS und 438 Kontrollen (SCC/BCC) in die Studie eingeschlossen. Die Einnahme von HCT war bei Patienten mit AFX/PDS (44,5%) im Vergleich zu Patienten mit SCC/BCC (25,3%) signifikant häufiger. Außerdem war Diabetes mellitus bei AFX/PDS‐Patienten signifikant häufiger.SchlussfolgerungenDiese Studie zeigt eine signifikant höhere Einnahme von HCT bei Patienten mit AFX/PDS im Vergleich zu SCC/BCC. Dies legt nahe, dass HCT ein Risikofaktor für AFX/PDS sein könnte. Darüber hinaus könnten ein Diabetes mellitus oder dessen Begleiterkrankungen mit einem erhöhten Risiko für AFX/PDS assoziiert sein.
Impact of a family history of mental disorders on the characteristics of patients with early psychosis
Authors: Pöthe Barbara , Conus Philippe , Golay Philippe 
Published: April 2024

AbstractAimChildren of parents with psychiatric illness have a higher risk of developing psychiatric disorders. This is particularly the case for psychoses and the evolution of these disorders could likely differ. The aim of this study was to study the impact of a first‐degree and second‐degree family history of psychiatric disorders (FHPD) on the characteristics of patients with early psychosis in a specialized programme.MethodThis research is a prospective study based on 408 patients aged 18–35 years enrolled in the Treatment and Early Intervention in Psychosis Program (TIPP) with a three‐years follow‐up. Various characteristics were compared between patients with first‐degree‐FHPD and those without, then between patients with 2nd degree‐FHPD and those without. The influence of the number of parents with first or second degree FHPD on clinical characteristics was also studied.ResultsOur results showed an influence of FHPD on the characteristics of patients presenting a first episode of psychosis. Over the 3 years of follow‐up, patients with at least one second‐degree relative showed more negative and depressive symptoms and poorer general functioning than patient who did not. The number of parents with first or second degree FHPD was also negatively associated with several clinical variables.ConclusionThe results of this study confirm the existence of a distinct premorbid profile and a different evolution in patients with FHPD, which is not limited to first‐degree relatives. This suggests the importance of specific needs that should be addressed during treatment.
Alteration of synaptic protein composition during developmental synapse maturation
Authors: Kaizuka Takeshi , Takumi Toru 
Published: April 2024

AbstractThe postsynaptic density (PSD) is a collection of specialized proteins assembled beneath the postsynaptic membrane of dendritic spines. The PSD proteome comprises ~1000 proteins, including neurotransmitter receptors, scaffolding proteins and signalling enzymes. Many of these proteins have essential roles in synaptic function and plasticity. During brain development, changes are observed in synapse density and in the stability and shape of spines, reflecting the underlying molecular maturation of synapses. Synaptic protein composition changes in terms of protein abundance and the assembly of protein complexes, supercomplexes and the physical organization of the PSD. Here, we summarize the developmental alterations of postsynaptic protein composition during synapse maturation. We describe major PSD proteins involved in postsynaptic signalling that regulates synaptic plasticity and discuss the effect of altered expression of these proteins during development. We consider the abnormality of synaptic profiles and synaptic protein composition in the brain in neurodevelopmental disorders such as autism spectrum disorders. We also explain differences in synapse development between rodents and primates in terms of synaptic profiles and protein composition. Finally, we introduce recent findings related to synaptic diversity and nanoarchitecture and discuss their impact on future research. Synaptic protein composition can be considered a major determinant and marker of synapse maturation in normality and disease.
Age, not autism, influences multisensory integration of speech stimuli among adults in a McGurk/MacDonald paradigm
Authors: Jertberg Robert M. , Begeer Sander , Geurts Hilde M. , Chakrabarti Bhismadev , Van der Burg Erik 
Published: April 2024

AbstractDifferences between autistic and non‐autistic individuals in perception of the temporal relationships between sights and sounds are theorized to underlie difficulties in integrating relevant sensory information. These, in turn, are thought to contribute to problems with speech perception and higher level social behaviour. However, the literature establishing this connection often involves limited sample sizes and focuses almost entirely on children. To determine whether these differences persist into adulthood, we compared 496 autistic and 373 non‐autistic adults (aged 17 to 75 years). Participants completed an online version of the McGurk/MacDonald paradigm, a multisensory illusion indicative of the ability to integrate audiovisual speech stimuli. Audiovisual asynchrony was manipulated, and participants responded both to the syllable they perceived (revealing their susceptibility to the illusion) and to whether or not the audio and video were synchronized (allowing insight into temporal processing). In contrast with prior research with smaller, younger samples, we detected no evidence of impaired temporal or multisensory processing in autistic adults. Instead, we found that in both groups, multisensory integration correlated strongly with age. This contradicts prior presumptions that differences in multisensory perception persist and even increase in magnitude over the lifespan of autistic individuals. It also suggests that the compensatory role multisensory integration may play as the individual senses decline with age is intact. These findings challenge existing theories and provide an optimistic perspective on autistic development. They also underline the importance of expanding autism research to better reflect the age range of the autistic population.
Electrographic screening for infantile epileptic spasms syndrome in a single sleep–wake cycle
Authors: Mason John A. , Juarez‐Colunga Elizabeth , Knupp Kelly G. 
Published: April 2024

AbstractObjectiveInfantile epileptic spasms syndrome (IESS) is a common and urgent diagnosis with seizure and nonseizure mimics. Evaluation with prolonged video–electroencephalography (EEG) can be time‐consuming and costly. This study investigated the use of EEG review of a single sleep–wake cycle to exclude IESS.MethodsWe retrospectively reviewed video‐EEG studies to rule out IESS in children between the ages of 2 months and 2 years in the period from January 2019 through June 2020. EEG studies were reviewed from the start of the recording through the first sleep–wake cycle and scored as “normal,” “consistent with IESS,” or “abnormal but not diagnostic of IESS.” Scores were compared to the clinical report created by analysis of the entire video‐EEG.ResultsInclusion criteria were met in 238 EEG studies. The mean patient age was 7.6 months. The median duration of the full study was 908 min, compared to 107.5 min for the first sleep–wake cycle only. The median difference in recording time was 801 min, p‐value < .01. Scored outcomes were similar. Sixty‐eight percent of EEG studies were scored as “normal” on first sleep–wake cycle review as compared to 63% on full study review, 13% scored as “consistent with IESS” compared to 16% and 19% scored as “abnormal but not diagnostic of IESS” compared to 21%. Sensitivity and specificity of the first sleep–wake cycle review for studies “consistent with IESS” was 84% and 100%, respectively. No cases of IESS were scored as normal on first sleep–wake cycle review.SignificanceA single sleep–wake cycle captured on EEG can triage studies when IESS is suspected. A normal first sleep–wake cycle did not miss cases of IESS and could result in reduced EEG recording time. Because most of these cases presented to an emergency department, a normal first sleep–wake cycle may help providers determine the acuity, or necessity, of further testing.
DFEF: Diversify feature enhancement and fusion for online knowledge distillation
Authors: Liang Xingzhu , Zhang Jian , Liu Erhu , Fang Xianjin 
Published: April 2024

AbstractTraditional knowledge distillation relies on high‐capacity teacher models to supervise the training of compact student networks. To avoid the computational resource costs associated with pretraining high‐capacity teacher models, teacher‐free online knowledge distillation methods have achieved satisfactory performance. Among these methods, feature fusion methods have effectively alleviated the limitations of training without the strong guidance of a powerful teacher model. However, existing feature fusion methods often focus primarily on end‐layer features, overlooking the efficient utilization of holistic knowledge loops and high‐level information within the network. In this article, we propose a new feature fusion‐based mutual learning method called Diversify Feature Enhancement and Fusion for Online Knowledge Distillation (DFEF). First, we enhance advanced semantic information by mapping multiple end‐of‐network features to obtain richer feature representations. Next, we design a self‐distillation module to strengthen knowledge interactions between the deep and shallow network layers. Additionally, we employ attention mechanisms to provide deeper and more diversified enhancements to the input feature maps of the self‐distillation module, allowing the entire network architecture to acquire a broader range of knowledge. Finally, we employ feature fusion to merge the enhanced features and generate a high‐performance virtual teacher to guide the training of the student model. Extensive evaluations on the CIFAR‐10, CIFAR‐100, and CINIC‐10 datasets demonstrate that our proposed method can significantly enhance performance compared to state‐of‐the‐art feature fusion‐based online knowledge distillation methods. Our code can be found at https://github.com/JSJ515-Group/DFEF-Liu.
Migration choices for farming households in rural areas: Why new countryside locations are important for the inhabitants of traditional agricultural areas in central China
Authors: Shen Haojing , Song Yan , Shan Zhengying 
Published: April 2024

AbstractIn the urbanisation stage of bilateral urban–rural interaction, China is adopting various policies to achieve rural revitalisation and provide diverse destinations to which farmers can migrate. Most previous studies have focused on urban destinations; thus, new countryside locations are not as well understood in this context. This study focused on first migration practices to examine new countryside destinations for farmers in China. This study established a conceptual framework to explain the diverse migration destination options based on three aspects: human capital, economic characteristics, and social characteristics. Based on survey data from farming households in a traditional agriculture area in Xinxiang, a multiple logit model was used to examine why new countryside destinations were adaptive first migration destinations. The results indicated that farmers were influenced by land capital and low initial household incomes. Specifically, many farmers were attracted to new countryside locations close to their original villages because of the need for cultivated land and farming, thus providing a logical first move in the rural–urban migration process. Poorer households were willing to first improve their living conditions in this way. This suggests that new countryside construction can help achieve rural revitalisation.
The importance and evolution of bleeding disorder registries
Authors: Tran Huyen , Yang Renchi , Fischer Kathelijn , Makris Michael , Konkle Barbara A. 
Published: April 2024

AbstractRegistries are excellent sources of data to address questions that are typically not evaluated in randomized clinical trials, including natural history, disease prevalence, treatment approaches and adverse events, and models of care. Global and regional registries can provide data to identify differences in outcomes and in haemophilia care between countries, economic settings, and regions, while facilitating research and data sharing. In this manuscript, we highlight five bleeding disorder registries: Country registries from Australia and China, Paediatric Network on Haemophilia Management (PedNet) data on children who have received emicizumab, data from the European Haemophilia Safety Surveillance (EUHASS) system, and data on women and girls with haemophilia from the World Federation of Haemophilia (WFH) registries. Data from these and other bleeding disorder registries have been and will continue to be used to advance patient care, understand treatment patterns and adverse reactions, and identify areas of increased need and focus.
Epidemiological assessment of hepatitis E virus infection among 1565 pregnant women in Siem Reap, Cambodia using an in‐house double antigen sandwich ELISA
Authors: Mirzaev Ulugbek Khudayberdievich , Ko Ko , E Bunthen , Phyo Zayar , Chhoung Chanroth , Ataa Akuffo Golda , Sugiyama Aya , Akita Tomoyuki , Takahashi Kazuaki , Tanaka Junko 
Published: April 2024

AbstractAimThis study investigated hepatitis E virus (HEV) prevalence among pregnant women in Siem Reap, Cambodia, by developing a cost‐effective, user‐friendly in‐house enzyme‐linked immunosorbent assay (ELISA) for detecting total anti‐HEV immunoglobulins (Ig).MethodsThe in‐house ELISA was designed for large‐scale screening in resource‐limited settings. Its performance was benchmarked against two commercial tests: the Anti‐HEV IgG EIA (Institute of Immunology, Co. Ltd) and the Anti‐HEV IgG RecomLine LIA (Mikrogen). The in‐house ELISA demonstrated a sensitivity of 76% and 71.4%, and a specificity of 94.1% and 98.6%, against the two commercial tests, respectively, with overall agreement rates of 92.4% and 94.3%.ResultsAmong 1565 tested pregnant women, 11.6% were anti‐HEV positive. Prevalence increased with age, particularly in women aged 35–40 years and over 40 years. No significant associations were found with education, number of children, family size, or history of blood transfusion and surgery, except for the occupation of the family head as a public officer. Of the total anti‐HEV positive women, 22.7% had anti‐HEV IgM, indicating recent or ongoing infection.ConclusionThe study concluded that the in‐house ELISA is a viable option for HEV screening in regions with limited resources due to its high accuracy and cost‐effectiveness. It is particularly suitable for large‐scale studies and public health interventions in areas where HEV is endemic and poses a significant risk to pregnant women.
The status and influencing factors of fatigue in kidney transplant recipients based on the theory of unpleasant symptoms: A cross‐sectional study in China
Authors: Liu Sai , Shen Yuehan , Nie Manhua , Fang Chunhua , Dai Helong , Yao Ming , Zhou Xihong 
Published: April 2024

AbstractAimsThis study describes the incidence of fatigue in kidney transplant recipients and analyses the relationship between physiological factors, psychological factors, situational factors and fatigue in kidney transplant recipients.BackgroundFatigue, as a common symptom after kidney transplantation, is affected by many factors, but the influence of some factors on the fatigue of kidney transplant recipients is still controversial.DesignThis cross‐sectional study was designed based on the theory of unpleasant symptoms.MethodsOur survey involved 307 participants attending the kidney transplant outpatient clinic of a tertiary Class A hospital (Changsha, Hunan, China). Data were collected between February and April 2021 using a structured questionnaire and electronic medical records. Data were analysed using IBM SPSS 25.0 (SPSS Inc.)ResultsIt was found that the incidence of fatigue in kidney transplant recipients was 53.1%. According to the binary logistic regression analysis, sleep quality, hypokalemia, anxiety, depression and education level were independent risk factors for fatigue in kidney transplant recipients.ConclusionThe incidence of fatigue in kidney transplant recipients was high and was influenced by physical, psychological and situational factors. Clinical nurses should assess fatigue levels in a timely and multidimensional manner in clinical practice and provide effective and scientific guidance about fatigue self‐coping and symptom management for kidney transplant recipients.
Psychometric testing of the Thai version of Caregiver Contribution to Self‐Care of Chronic Illness Inventory version 2
Authors: Kumanjan Wanna , Suwanno Jom , Koson Naruebeth , Bunsuk Chonchanok , Klinjun Nuntaporn , Srisomthrong Kannika , Phonphet Chennet , Mayurapak Chidchanog , Dansuwan Chutiporn , Suwanno Juk , Chramnanpho Punnaphat , Kamlungdee Umaporn , Arab Wichai , Ninla‐aesong Putrada , Hamilton Sadee Saithong , Thiamwong Ladda 
Published: April 2024

AbstractAimTo assess the psychometric properties of the Thai version of Caregiver Contribution to Self‐Care of Chronic Illness Inventory version 2 (CC‐SC‐CII‐v2) among primary caregivers of individuals with any single or multiple chronic illnesses.BackgroundThe instrument encompasses three scales that evaluate Caregiver Contribution to Self‐Care (CC‐SC) Maintenance, Monitoring and Management.MethodsThe English version CC‐SC‐CII‐v2 was translated and adapted for Thai context, and a cross‐sectional multicenter study involved 430 caregivers from 16 primary care centres in Thailand. Structural validity, internal consistency reliability and test–retest reliability were examined.ResultsThe original two‐factor CC‐SC Maintenance scale required a re‐specified model for good fit, while the CC‐SC Monitoring and CC‐SC Management scales fit well. The simultaneous model of three scales demonstrated satisfactory fit. The CC‐SC Maintenance and CC‐SC Management scales both had a composite reliability index of 0.85, with omega coefficients of 0.86 and 0.83, respectively. CC‐SC Monitoring had an alpha coefficient of 0.89. The intraclass correlation coefficients ranging from 0.84 to 0.91, indicating good test–retest reliability.ConclusionThe Thai CC‐SC‐CII‐v2 is a valid and reliable instrument that can provide clinicians and investigators with an evaluation of the contributions of caregivers to the self‐care of patients with chronic illnesses.