bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysing exploration uncertainties by tight integration of seismic and hydrocarbon migration modelling
Authors: Sylta Øyvind 
Published: October 2008

High success rates in the exploration for oil and gas can be achieved by incorporating best practice strategies in estimating the geological uncertainties from seismic data and geological models. A tight coupling of the seismic information and hydrocarbon migration modelling may allow for a consistent handling of uncertainties throughout the analysis. Seismic uncertainties include velocities used for depth conversion, the positioning of structural interpretations including faults, and assigning flow properties from seismic attributes. The necessary output from the seismic uncertainty analysis could be provided as uncertainty fields that may be used as input to hydrocarbon migration modelling.
The nonlinearity of the hydrocarbon migration process, including flow-path selection and trap phase filtering, frequently requires that local uncertainties are addressed in more detail. These uncertainties may require high-resolution seismic analyses in order to be further resolved. The structural interpretation is of particular importance to accumulation uncertainties, and fault juxtaposition and carrier dip direction uncertainty estimations can improve phase prediction estimates in exploration prospects. It is suggested that an improved best practice for exploration for oil and gas should include a tight coupling of the handling of uncertainties from seismic data in hydrocarbon migration modelling.
Distinct Orbitofrontal Regions Encode Stimulus and Choice Valuation
Authors: Cunningham William A. , Kesek Amanda , Mowrer Samantha M. 
Published: October 2008

Abstract
The weak axiom of revealed preferences suggests that the value of an object can be understood through the simple examination of choices. Although this axiom has driven economic theory, the assumption of equation between value and choice is often violated. fMRI was used to decouple the processes associated with evaluating stimuli from evaluating one's actions. Whereas activity in left posterior areas of the orbitofrontal cortex (OFC) was associated with processing the objective value of stimuli, activity in medial anterior areas of the OFC was associated with accepting high value gambles and rejecting low value gambles; that is, making correct decisions. These data demonstrate that distinct areas of the OFC provide dissociated representations for use in adaptive decision-making and suggest an important processing distinction between the concepts of good/bad and right/wrong.
Neurophysiological Correlates of Comprehending Emotional Meaning in Context
Authors: Holt Daphne J. , Lynn Spencer K. , Kuperberg Gina R. 
Published: October 2008

Abstract
Although the neurocognitive mechanisms of nonaffective language comprehension have been studied extensively, relatively less is known about how the emotional meaning of language is processed. In this study, electrophysiological responses to affectively positive, negative, and neutral words, presented within nonconstraining, neutral contexts, were evaluated under conditions of explicit evaluation of emotional content (Experiment 1) and passive reading (Experiment 2). In both experiments, a widely distributed Late Positivity was found to be larger to negative than to positive words (a “negativity bias”). In addition, in Experiment 2, a small, posterior N400 effect to negative and positive (relative to neutral) words was detected, with no differences found between N400 magnitudes to negative and positive words. Taken together, these results suggest that comprehending the emotional meaning of words following a neutral context requires an initial semantic analysis that is relatively more engaged for emotional than for nonemotional words, whereas a later, more extended, attention-modulated process distinguishes the specific emotional valence (positive vs. negative) of words. Thus, emotional processing networks within the brain appear to exert a continuous influence, evident at several stages, on the construction of the emotional meaning of language.
A Literature Review of Health Care Professional Attitudes Toward Complementary and Alternative Medicine
Authors: Sewitch Maida J. , Cepoiu Monica , Rigillo Nicole , Sproule Donald 
Published: October 2008

Objective. To summarize health care professionals' attitudes toward complementary and alternative medicine (CAM). Methods. In October 2006, we searched Allied and Complementary Medicine Database (AMED; 1985—2006), Excerpta Medica Database (EMBASE; 1980—2006), and MED-LINE (1960—2006) for Canadian or US studies of health care professionals' attitudes toward CAM, published in English or French. Results. A total of 21 surveys of physicians, nurses, public health professionals, dietitians, social workers, medical/nursing school faculty, and pharmacists were included that focused on beliefs about CAM efficacy, personal use, clinical practice use and referrals, communication with patients about CAM, level of knowledge, and the need for information regarding various CAM therapies. Physicians were more negative compared to other health care professionals. Positive attitudes toward CAM did not correlate with CAM referral or prescription patterns. Health care professionals of all disciplines wanted more information about CAM. Conclusions. Heterogeneity in the CAM definition and questionnaire items precluded summarizing health care professionals' attitudes toward CAM. Providing CAM education to health care professionals may help to integrate CAM into mainstream medical care.
Long-term survival in Waldenstrom macroglobulinemia: 10-year follow-up of Southwest Oncology Group–directed intergroup trial S9003
Authors: Dhodapkar Madhav V. , Hoering Antje , Gertz Morie A. , Rivkin Saul , Szymonifka Jackie , Crowley John , Barlogie Bart 
Published: October 2008

AbstractThe survival of patients with Waldenstrom macroglobulinemia (WM) varies enormously. The development of prognostic models in WM has been fraught by limited follow-up in current studies. Here, we update the outcome of a prospective WM trial with a median follow-up of 10 years for live patients. Of the 59 previously untreated patients who initially were observed, only 12 patients (21%) required therapy at a median follow-up of 100 months. Multivariate analysis among the 183 patients requiring therapy reaffirmed age 70 years or greater, previous nonprotocol therapy, and β-2 microglobulin (B2M) of 3 mg/dL or greater as prognostic factors. Importantly, increased serum lactate dehydrogenase (LDH) was identified as an additional independent variable, which improved risk assessment beyond the recent WM international prognostic scoring system (ISSWM). By using age, previous therapy, B2M, and LDH, we identified 3 risk groups with 8-year survival estimates of 55%, 33%, and 5% (P < .001). These data provide novel insights into factors predicting long-term outcome in WM. This trial has been registered with www.cancer.gov under ID 4852904.
Cell signaling and transcription factor genes expressed during whole body regeneration in a colonial chordate
Authors: Rinkevich Yuval , Rinkevich Baruch , Reshef Ram 
Published: October 2008

Abstract

Background
The restoration of adults from fragments of blood vessels in botryllid ascidians (termed whole body regeneration [WBR]) represents an inimitable event in the chordates, which is poorly understood on the mechanistic level.

Results
To elucidate mechanisms underlying this phenomenon, a subtracted EST library for early WBR stages was previously assembled, revealing 76 putative genes belonging to major signaling pathways, including Notch/Delta, JAK/STAT, protein kinases, nuclear receptors, Ras oncogene family members, G-Protein coupled receptor (GPCR) and transforming growth factor beta (TGF-β) signaling. RT-PCR on selected transcripts documented specific up-regulation in only regenerating fragments, pointing to a broad activation of these signaling pathways at onset of WBR. The followed-up expression pattern of seven representative transcripts from JAK/STAT signaling (Bl-STAT), the Ras oncogene family (Bl-Rap1A, Bl-Rab-33), the protein kinase family (Bl-Mnk), Bl-Cnot, Bl-Slit and Bl-Bax inhibitor, revealed systemic and site specific activations during WBR in a sub-population of circulatory cells.

Conclusion
WBR in the non-vertebrate chordate Botrylloides leachi is a multifaceted phenomenon, presided by a complex array of cell signaling and transcription factors. Above results, provide a first insight into the whole genome molecular machinery of this unique regeneration process, and reveal the broad participation of cell signaling and transcription factors in the process. While regeneration involves the participation of specific cell populations, WBR signals are systemically expressed at the organism level.
Calculating expected DNA remnants from ancient founding events in human population genetics
Authors: Stacey Andrew , Sheffield Nathan C , Crandall Keith A 
Published: October 2008

Abstract

Background
Recent advancements in sequencing and computational technologies have led to rapid generation and analysis of high quality genetic data. Such genetic data have achieved wide acceptance in studies of historic human population origins and admixture. However, in studies relating to small, recent admixture events, genetic factors such as historic population sizes, genetic drift, and mutation can have pronounced effects on data reliability and utility. To address these issues we conducted genetic simulations targeting influential genetic parameters in admixed populations.

Results
We performed a series of simulations, adjusting variable values to assess the affect of these genetic parameters on current human population studies and what these studies infer about past population structure. Final mean allele frequencies varied from 0.0005 to over 0.50, depending on the parameters.

Conclusion
The results of the simulations illustrate that, while genetic data may be sensitive and powerful in large genetic studies, caution must be used when applying genetic information to small, recent admixture events. For some parameter sets, genetic data will not be adequate to detect historic admixture. In such cases, studies should consider anthropologic, archeological, and linguistic data where possible.
Selection and mutation on microRNA target sequences during rice evolution
Authors: Guo Xingyi , Gui Yijie , Wang Yu , Zhu Qian-Hao , Helliwell Chris , Fan Longjiang 
Published: October 2008

Abstract

Background
MicroRNAs (miRNAs) posttranscriptionally down-regulate gene expression by binding target mRNAs. Analysis of the evolution of miRNA binding sites is helpful in understanding the co-evolution between miRNAs and their targets. To understand this process in plants a comparative analysis of miRNA-targeted duplicated gene pairs derived from a well-documented whole genome duplication (WGD) event in combination with a population genetics study of six experimentally validated miRNA binding sites in rice (O. sativa) was carried out.

Results
Of the 1,331 pairs of duplicate genes from the WGD, 41 genes (29 pairs) were computationally predicted to be miRNA targets. Sequence substitution analysis indicated that the synonymous substitution rate was significantly lower in the miRNA binding sites than their 5' and 3' flanking regions. Of the 29 duplicated gene pairs, 17 have only one paralog been targeted by a miRNA. This could be due to either gain of a miRNA binding site after the WGD or because one of the duplicated genes has escaped from being a miRNA target after the WGD (loss of miRNA binding site). These possibilities were distinguished by separating miRNAs conserved in both dicots and monocot plants from rice-specific miRNAs and by phylogenetic analysis of miRNA target gene families. The gain/loss rate of miRNA binding sites was estimated to be 3.0 × 10-9 gain/loss per year. Most (70.6%) of the gains/losses were due to nucleotide mutation. By analysis of cultivated (O. sativa; n = 30) and wild (O. rufipogon; n = 15) rice populations, no segregating site was observed in six miRNA binding sites whereas 0.12–0.20 SNPs per 21-nt or 1.53–1.80 × 10-3 of the average pairwise nucleotide diversity (π) were found in their flanking regions.

Conclusion
Both molecular evolution and population genetics support the hypothesis that conservation of miRNA binding sites is maintained by purifying selection through elimination of deleterious alleles. Nucleotide mutations play a major role in the gain/loss of miRNA binding sites during evolution.
Acne vulgaris, mental health and omega-3 fatty acids: a report of cases
Authors: Rubin Mark G , Kim Katherine , Logan Alan C 
Published: October 2008

AbstractAcne vulgaris is a common skin condition, one that is associated with significant psychological disability. The psychological impairments in acne include higher rates of depression, anxiety, anger and suicidal thoughts. Despite a paucity of clinical research, patients with skin conditions and/or mental health disorders are frequent consumers of dietary supplements. An overlap may exist between nutrients that potentially have both anti-acne and mood regulating properties; examples include omega-3 fatty acids from fish oil, chromium, zinc and selenium. Here we report on five cases of acne treated with eicosapentaenoic acid and antioxidant nutrients. Self-administration of these nutrients may have improved inflammatory acne lesions and global aspects of well-being; the observations suggest a need for controlled trials.
Resection of giant ethmoid osteoma with orbital and skull base extension followed by duraplasty
Authors: Yiotakis Ioannis , Eleftheriadou Anna , Giotakis Evagelos , Manolopoulos Leonidas , Ferekidou Eliza , Kandiloros Dimitrios 
Published: October 2008

Abstract

Background
Osteomas of ethmoid sinus are rare, especially when they involve anterior skull base and orbit, and lead to ophthalmologic and neurological symptoms.

Case presentation
The present case describes a giant ethmoid osteoma. Patient symptoms and signs were exophthalmos and proptosis of the left eye, with progressive visual acuity impairment and visual fields defects. CT/MRI scanning demonstrated a huge osseous lesion of the left ethmoid sinus (6.5 cm × 5 cm × 2.2 cm), extending laterally in to the orbit and cranially up to the anterior skull base. Bilateral extensive polyposis was also found. Endoscopic and external techniques were combined to remove the lesion. Bilateral endoscopic polypectomy, anterior and posterior ethmoidectomy and middle meatus antrostomy were performed. Finally, the remaining part of the tumor was reached and dissected from the surrounding tissue via a minimally invasive Lynch incision around the left middle canthus. During surgery, CSF rhinorrhea was observed and leakage was grafted with fascia lata and coated with bio-glu. Postoperatively, symptoms disappeared. Eighteen months after surgery, the patient is still free of symptoms.

Conclusion
Before management of ethmoid osteomas with intraorbital and skull base extension, a thorough neurological, ophthalmological and imaging evaluation is required, in order to define the bounders of the tumor, carefully survey the severity of symptoms and signs, and precisely plan the optimal treatment. The endoscopic procedure can constitute an important part of surgery undertaken for giant ethmoidal osteomas. In addition, surgeons always have to take into account a possible CSF leak and they have to be prepared to resolve it.
Motion compensation with a scanned ion beam: a technical feasibility study
Authors: Grözinger Sven Oliver , Bert Christoph , Haberer Thomas , Kraft Gerhard , Rietzel Eike 
Published: October 2008

Abstract

Background
Intrafractional motion results in local over- and under-dosage in particle therapy with a scanned beam. Scanned beam delivery offers the possibility to compensate target motion by tracking with the treatment beam.

Methods
Lateral motion components were compensated directly with the beam scanning system by adapting nominal beam positions according to the target motion. Longitudinal motion compensation to mitigate motion induced range changes was performed with a dedicated wedge system that adjusts effective particle energies at isocenter.

Results
Lateral compensation performance was better than 1% for a homogeneous dose distribution when comparing irradiations of a stationary radiographic film and a moving film using motion compensation. The accuracy of longitudinal range compensation was well below 1 mm.

Conclusion
Motion compensation with scanned particle beams is technically feasible with high precision.
Delayed involution of lactation presenting as a non-resolving breast mass: a case report
Authors: Kumar Yashwant , Chahal Alka , Garg Monika , Bhatia Alka , Mahajan NC , Ganju Anil 
Published: October 2008

Abstract

Introduction
Involution of lactation is a physiological process. Rarely, it may be delayed and troublesome for the lactating woman. Though lactation-induced changes in breast are well known, morphological features of delayed involution are not clear.

Case presentation
We report a case of a 22-year-old lactating mother who presented with a painful, non-resolving breast mass 5 months after delivery. Clinically, it simulated an inflammatory carcinoma. Histopathology, however, revealed involuting lactational changes.

Conclusion
To the best of our knowledge, lactational involution with such a presentation has not been described in the English literature. The case needs to be reported so that this entity can be considered among the differential diagnoses of breast masses in a lactating patient.
Religion as an index of the rise and fall of ‘moral treatment’ in 19th century lunatic asylums in England
Authors: Rollin Henry R. 
Published: October 2008

“…; and the tone of the chapel bell, coming across the Valley of the Brent, still reminds me, morning and evening, of the weft-remembered and mingled congregation of the afflicted, and who are then assembling, humble yet hopeful, and not forgotten, and not spiritually deserted.”As a function of the Christian ethic, monasteries in Britain from the Middle Ages onwards set aside a section for the care of the sick. The monastic tradition ensured that the spiritual needs of the physically sick were well taken care of: chapels formed an integral part of the building complex and chaplains were, of course, constantly on tap. The mentally sick were less well served, however. For example, the second building to be occupied by St Luke's Hospital, London, opened in 1787, did not even boast a chapel, a distinction shared with Bethlem, the other major charity asylum, then occupying a purpose-built structure in Moorgate in the City of London.
A survey of the use of the electrocardiogram in psychiatry
Authors: Henderson Tom , Gallagher Dominic , Stark Cameron 
Published: October 2008

A survey was undertaken to ascertain if doctors working in psychiatry knew when to perform electrocardiograms (ECGs) prior to and during psychiatric treatments where indicated, and to investigate the training, confidence and ability of doctors in ECG interpretation. Half had received no training in the indications for performing an ECG. Opinion differed widely as to when to perform an ECG, with 54% stating an ECG was required before treatment with pimozide and only 19% and 11% stating ECGs were required during the course of treatment with pimozide and high dose antipsychotic medication respectively.Ability in ECG interpretation correlated negatively with time spent in psychiatry but no correlation existed between grade and ability to identify an ECG as normal or abnormal.
A glossary of television-related symptoms in psychosis
Authors: Smyth M. G. 
Published: October 2008

Although the attribution of psychotic symptoms to the television is widespread, there is little literature on the subject and one might surmise that the issue is considered so mundane as not to merit further interest.In so far as ‘reality’ is a critical problem in psychosis, television can constitute a particular source of confusion. ‘Reality’ can be fudged by this medium for us all, with editing, propaganda, and the spectrum of front line live reports, ‘real life’ re-enactments, and drama.
The odd couple: the partnership of J. C. Bucknill and D. H. Tuke
Authors: Beveridge Allan 
Published: October 2008

On the opening page of Daniel Hack Tuke's 1892Dictionary of Psychological Medicine, is a statement which reads:Dedicated to John Charles Bucknill, M.D. Lond. F.R.C.P., F.R.S., Late Lord Chancellors Visitor in Lunacy, First Editor of the ‘Journal of Mental Science’, and an early and strenuous worker in the field of psychological medicine.
Substance misuse in a chronic psychosis population Prevalence and staff perceptions
Authors: Brown Steve 
Published: October 2008

Aims and methodThis paper describes the prevalence of substance misuse in a population with chronic psychosis and compares the results with staff estimates. Keyworkers were interviewed using validated questionnaires.ResultsThe prevalence rate of substance misuse was higher than in the general population but significantly lower than staff estimates. Staff had little specific training or experience in treating substance misuse.Clinical implicationsSubstance misuse is a significant problem among patients with chronic psychosis. Service providers should ensure than staff working with these patients are adequately trained in the management of this problem.
Monitoring patients on high-dose antipsychotics
Authors: Barber Joan M. , Connaughton Jennifer , Wright Morag 
Published: October 2008

Aims and methodFollowing the publication of the 1994 Consensus Statement on the use of high-dose antipsychotic medication, we identified our high-dose patients and undertook an audit of the recommended physical investigations. The patients were identified by scrutiny of prescription records. Data were collected retrospectively at six-monthly intervals for four audit cycles. Results were fed back to clinicians at the hospital journal club.ResultsThe percentage of patients identified in the high-dose category fell from 35 to 23% over 18 months. Electrocardiograph monitoring of the group increased from 5 to 63%. Other tests showed a similar improvement. A very small number of abnormal results was shown. There were no untoward cardiac events.Clinical implicationsIntroduction of the standards of physical monitoring advised in the Consensus Statement has implications of cost to the NHS to be balanced against risk avoidance for patients. The number of abnormalities detected in our population was low. Changing prescribing behaviour in response to reported abnormal findings proved unexpectedly slow and a new system was required.
Proposed change in service delivery and stress among nursing staff
Authors: Shah Ajit , De Tamal 
Published: October 2008

Aims and methodThe impact of major organisational change in a psychogeriatric service was examined in a naturalistic and opportunistic study, which was prospectively conducted.ResultsA positive association between the organisational change of the proposed closure and relocation of a psychogeriatric ward and stress among the nursing staff as measured by the General Health Questionnaire was demonstrated.Clinical implicationsPolicy-makers, purchasers and providers need to consider the implication of such stress and develop strategies to minimise stress prior to any major policy change.