bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of the season-dependent component in the evaluation of morphological and biochemical blood parameters in Shetland ponies of both sexes during exercise
Authors: Tkaczenko Halina , Lukash Oleksandr , Kurhaluk Natalia 
Published: March 2024

Abstract

Introduction
Determination of morphological and biochemical blood indices facilitates assessment of the health and welfare of horses, their nutrient demand, the effects of training already undertaken, and the horses’ suitability for exercise. Identification of the season-dependent components and the effects of sex and exercise on changes in frequently referenced haematological and biochemical parameters was the main goal of the current study.

Material and Methods
The blood morphology of 21 healthy adult Shetland ponies (11 mares and 10 stallions) aged 6.5 ± 1.4 years from the central Pomeranian region in Poland was analysed. Blood samples were taken once per season for one year.

Results
No statistically significant season-dependent differences were found in the blood morphology parameters in either mares or stallions before or after exercise. Beta-coefficient results revealed the strength and type of the relationship of red blood cell distribution width (RDW) and granulocyte count (GRA) with the season, of red blood cell count (RBC), haematocrit, mean corpuscular volume and mean platelet volume with the sex, and of RDW, white blood cell count, GRA and RBC with the exercise factor. Biomarkers demonstrating the relationship between aerobic and anaerobic levels of energy metabolism in the blood did not show any sex dependency in regression analysis.

Conclusion
The sex-independence of energy metabolism biomarkers may indicate the universality of these parameters. Both seasonality itself and its combination with the exercise factor took part in the formation of effective adaptive reactions for maintenance of morphological blood indices in the ponies during exercise.
Phylogenetic analysis of the trypanosomatid parasite Lotmaria passim in honey bees (Apis mellifera) in Poland
Authors: Iller Maria , Lipczyńska-Ilczuk Karolina , Sokół Rajmund , Borsuk Grzegorz , Bancerz-Kisiel Agata 
Published: March 2024

Abstract

Introduction

Lotmaria passim (L. passim) is a single-celled flagellate which colonises the bee gastrointestinal tract and is highly prevalent in honey bees. This parasite is associated with colony losses. Honey bee (Apis mellifera) colonies were sampled from five apiaries in the north-eastern part of Poland for the phylogenetic analysis of L. passim.

Material and Methods
Each apiary consisted of approximately 60 bee colonies, of which 20 were randomly selected. Samples of 60 differently aged worker bees were collected from each colony and pooled. A total of 100 bee colonies from five apiaries were examined. Protozoa of the Trypanosomatidae family were identified by PCR. L. passim was detected in 47 (47%) of the samples. The 18S ribosomal (r) RNA amplicons of L. passim were sequenced by a commercial service. Their sequences were analysed with BLASTN and noted to be compatible with the GenBank sequences of this region of the organism’s genome. A sequence analysis was performed using the BioEdit Sequence Alignment Editor and Clustal W software.

Results
The amplicon sequences of L. passim were 100% homologous with the sequences deposited in GenBank under accession numbers KM066243.1., KJ684964.1 and KM980181.1.

Conclusion
This is the first study to perform a phylogenetic analysis of L. passim in Polish honey bees. The analysis demonstrated high levels of genetic similarity between isolates of L. passim colonising apiaries in the north-eastern region of Poland.
Serological characterisation of Lagovirus virus-like particles originating from native and mutated VP60 of rabbit haemorrhagic disease virus 2 and European brown hare syndrome virus
Authors: Krejmer-Rąbalska Martyna , Peplińska Marta , Szewczyk Bogusław , Fitzner Andrzej 
Published: March 2024

Abstract

Introduction
Since lagoviruses cannot be cultivated in vitro, using expression systems is an alternative and promising way of producing diagnostic viral antigens. It opens up their use as active immunogens for vaccine production.

Material and Methods
Virus-like particles (VLPs) were produced in a baculovirus expression system in Spodoptera frugiperda 9 (Sf9) insect cells based on wild-type and mutated variants of the virus capsid VP60 protein from a Polish strain of European brown hare syndrome virus (EBHSV) and wild-type and mutated versions of this protein from a Polish strain of rabbit haemorrhagic disease virus 2 (RHDV2). The mutations were the substitution of an arginylglycylaspartic acid (Arg-Gly-Asp/RGD) motif in the P2 subdomain and, in the S or P2 domain, the substitution of three lysines. The VLPs were purified with sucrose gradient ultracentrifugation.

Results
Protein production was confirmed by Western blot analysis using rabbit or hare sera and ELISA tests with different types of monoclonal antibody. The haemagglutination properties of some VLPs were also evaluated. Electron microscopy of wild-type EBHSV, wild-type RHDV2 and the four VP60 variants produced in this experiment revealed the formation of characteristic VLP structures.

Conclusion
For the first time, mutated VLPs of RHDV2 with an RGD motif in the VP60 sequence were obtained, which could potentially be used to deliver cargo to eukaryotic cells. Virus-like particles based on the VP60 proteins of EBHSV and RHDV with a three-lysine substitution in the S or P2 domains were also obtained. Potential exists for VLPs of EBHSV and RHDV2 as vaccine candidates.
Transforming Megacities: Value and Impacts of Mixed-Use Developments with Multi-Criteria Decision-Making
Authors: Valero Alfonso 
Published: March 2024

Abstract
This research article explores the valuation of mixed-use developments and their impact on urban planning and city regeneration. The study introduces a Multi-Criteria Decision Making (MCDM) methodology to analyze complex buildings developed in Shanghai from 2009 to 2019. Two MCDM appraisals are offered in different developments using three groups of key indicators that served as benchmarks for other Chinese clusters and global megacities. The article addresses two primary research questions: how mixed-use assets can be assessed using MCDM, and what the key performance indicators and factors contributing to the success of mixed-use developments are. The findings highlight the importance of connectivity, previous real estate experience, ESG strategies, international branding, architectural design, financial metrics, and adaptability of the real estate industry in evaluating mixed-use assets. The study provides insight to stakeholders involved in real estate development, including urban planners, developers, and investors, enabling them to make informed decisions and improve sustainable practices. The research also highlights the importance of considering ESG principles, community benefits, and long-term strategies when assessing mixed-use developments to drive social change and contribute to urban regeneration.
Exploring Public Interest in Limited-Use Areas and Compensation from Airports in Poland: A Google Trends Analysis
Authors: Bełej Mirosław 
Published: March 2024

Abstract
This article evaluates online social behavior regarding the establishment of limited-use areas (LUAs) around the airports in Warsaw and Gdansk. The study relied mainly on an analysis of Google Trends statistics, in particular the dynamics of keyword searches. The article suggests that assessments of online behavior can provide a deeper understanding of social behavior. The study involved an OLS regression analysis and a causal impact analysis of the intervention based on a Bayesian structural time-series model. This article analyses different phases of an information society's activity, from the introduction of LUAs around airports to the deadline for submitting compensation claims. The results indicate that the number of searches for the keyword "compensation" increased significantly after the introduction of LUAs and that RSV decreased after the end of the compensation process, which confirms that the intervention significantly influenced the analyzed time series.
Massive primary pulmonary artery rhabomyosarcoma: A case report
Authors: Rashidi Farid , Bilehjani Eissa , Mousavi-Aghdas Seyed Ali , Parvizi Rezayat 
Published: March 2024

Abstract

Background:
Pulmonary artery sarcomas (PAS) are rare tumours causing an insidiously progressive obstruction of the pulmonary circulation. The clinical presentation is often indistinguishable from chronic thromboembolic pulmonary hypertension (CTEPH). However, the atypical appearance of a heterogeneous filling defect in CT pulmonary angiography (CTPA) should prompt further investigation.

Case Presentation:
A previously healthy young man presented with massive haemoptysis, acute respiratory distress, and progressive exertional dyspnea since the year before. Echocardiography demonstrated severe right ventricular dysfunction and highly probable pulmonary hypertension. CTPA revealed an extensive filling defect with an appearance concerning PAS. Due to syncopal episodes at rest, the patient underwent urgent pulmonary artery endarterectomy (PEA). A massive tree-like tumour was excised as a result. Post-operatively, reperfusion injury and refractory pulmonary oedema mandated extracorporeal membrane oxygenation (ECMO). Unfortunately, ECMO was complicated with massive haemolysis and acute kidney injury. The patient succumbed to multi-organ failure. Through tissue analysis established a diagnosis of embryonal rhabdomyosarcoma.

Discussion:
Unfortunately, the patient had not reached out for his worsening dyspnea. PASs should not be mistaken for a thrombus and anticoagulation should be avoided. The urgent condition precluded biopsy and tissue diagnosis. Similarly, neoadjuvant chemotherapy was not feasible. Post-operatively, reperfusion injury and pulmonary oedema ensued, which mandated ECMO. This complication should be anticipated preoperatively. There is a need for more data on PASs to establish a consensus for management.
Correlation Between Water Quality and the Diversity Index of the Bosna River in the Zenica Region (Bosnia and Herzegovina)
Authors: Beganović Sanela , Adrović Avdul , Prcanović Halim , Duraković Mirnes 
Published: March 2024

Abstract
Using the Shannon-Weaver index (H’), the link between the physical and chemical components of the biological component in the Bosnia River was examined. The results showed that pH and H’ had a strong link (rs = 0.59), while total nitrogen and H’ had a poor relationship (rs = 0.44), and COD-Cr had a weak relationship (rs = 0.34). KPK-Cr (I water class) had the lowest parameter concentrations, whereas electrical conductivity (IV-V water class) showed the highest. The values of the biological elements range from a poor 0.267 to a high state of 2.26.
Environment Social Governance Performance and Capital Structure: Evidence in Indonesia and Malaysia
Authors: Wahyuningtyas Endah Tri , Majidi Lalu Muhammad Syahril , Murtadho Muis , Musriha  , Susesti Dina Anggraeni , Primasari Niken Savitri 
Published: March 2024

Purpose: This research aims to investigate the relationship between Environmental, Social, and Governance (ESG) performance and capital structure, using Debt-to-Equity Ratio (DER) and Debt-to-Asset Ratio (DAR) proxies, in Indonesia and Malaysia. The study seeks to address the gap in the literature by exploring how ESG factors influence the capital structure decisions of both financial and non-financial companies in these countries. Additionally, the research analyzes the impact of ESG performance on the cost of equity and cost of debt.

Methods: The research utilizes secondary data extracted from annual reports and sustainability reports spanning from 2015 to 2020. A total of 102 companies, comprising 59 Indonesian companies and 52 Malaysian companies registered on CSRHub, are included in the analysis. ESG performance is assessed based on community, environmental, social, and governance indicators. Capital structure is measured using DER and DAR proxies. Statistical analysis techniques are employed to examine the relationship between ESG performance and capital structure, as well as its impact on the cost of equity and cost of debt.

Results and Discussion: The research findings indicate that community, environmental, social, and governance performance exhibit a negative effect on the cost of equity, suggesting that companies with stronger ESG performance experience lower costs of equity financing. However, these ESG factors do not significantly affect the cost of debt. This implies that while ESG performance may influence equity holders' perceptions of risk and return, it may not have a direct impact on the cost of debt financing for companies in Indonesia and Malaysia.

Implications of the Research: The results of this research have important implications for companies, investors, and policymakers interested in understanding the relationship between ESG performance, capital structure decisions, and financing costs. By demonstrating the impact of ESG factors on the cost of equity, the findings underscore the importance of integrating sustainability considerations into financial decision-making processes. Moreover, the research highlights the need for further investigation into the mechanisms through which ESG performance influences capital structure and financing costs.

Originality/Value: This study contributes to the literature by offering novel insights into the relationship between ESG performance and capital structure in Indonesia and Malaysia. By examining the impact of ESG factors on both equity and debt financing costs, the research expands our understanding of how sustainability considerations influence corporate financial decisions. The findings provide valuable guidance for companies seeking to enhance their ESG performance and optimize their capital structure, ultimately contributing to more sustainable and responsible business practices in emerging markets.
An Enterprise Architecture Planning for Tour and Travel Company Using TOGAF ADM
Authors: Bukhori Anung Style , Kurniastuti Ima , Yudianto Firman , Susanto Fajar Annas 
Published: March 2024

Purpose: This study aims to address inefficiencies in service delivery processes within PT. Auva Eqtena Tour and Travel, particularly concerning manual operations and administrative document management. By utilizing the TOGAF ADM (The Open Group Architecture Framework Architecture Development Method) methodology, the research seeks to develop a strategic plan for information systems that enhances service efficiency and streamlines operations.

Methods: The research employs the TOGAF ADM methodology to guide the strategic planning process for information systems improvement. Four key aspects are considered: vision architecture, business architecture, information system architecture, and technology architecture. Through a systematic approach, the study identifies areas for improvement and proposes strategic initiatives to optimize the utilization of information systems and technology.

Results and Discussion: Analysis of the current operational processes within PT. Auva Eqtena Tour and Travel reveals inefficiencies in manual operations and document management, leading to delays and increased resource consumption. The application of TOGAF ADM methodology facilitates the development of strategic plans across various architectural domains. The proposed initiatives include enhancements in vision architecture, business processes, information system integration, and technological infrastructure to optimize information system utilization and improve service delivery efficiency.

Implications of the Research: The findings have significant implications for PT. Auva Eqtena Tour and Travel, providing actionable insights for enhancing service efficiency and operational effectiveness through strategic information systems planning. By aligning business objectives with technology capabilities, the proposed initiatives aim to streamline processes, reduce costs, and enhance customer satisfaction.

Originality/Value: This study contributes to the existing literature by applying the TOGAF ADM methodology to address operational challenges within the tour and travel industry. By integrating strategic planning principles with architectural frameworks, the research offers a structured approach to information systems development and optimization. The proposed strategic plan provides a roadmap for PT. Auva Eqtena Tour and Travel to leverage information systems effectively, thereby enhancing its competitive position and service delivery capabilities in the market.
The Implementation of Satupadu.Id Digital Platform for Prospective Tutoring Teachers
Authors: Setiani Ani , Budiarti Isniar , Novendra Afief Maula , Almujab Saiful , Indriani Rina , Hamdani Acep Roni 
Published: March 2024

Purpose: The purpose of this research is to identify the implementation of the satupadu.id mobile-based tutoring booking application as an effort to accelerate the improvement of the quality of education.

Method: The research involves qualitative research with a qualitative descriptive approach. Qualitative research is a type of research whose results are not obtained by statistical processes or calculations but as a type of research that aims to describe phenomena in context using researchers in the study.

Results and conclusion: Based on literature review and regulatory analysis, the results of this study indicate that the process of finding a tutoring place through satupadu.id using the geotagging performance index is not optimal. Therefore, it is necessary to develop a web-based service-learning model using geotagging to improve blended learning. That way the mobile-based tutoring booking application will make it easier for students to find online tutoring online and teachers can offer products according to their abilities.

Research implications: The findings of this study have implications that the Satupadu.id application can make the perception of each student the same so that they have the same view on the information conveyed difficult if the information presented is detailed then this application can be very helpful in this case. Then the abstract subject matter becomes clear so that it is easy to understand. By using the application, student attention to the material can be increased.

Originality/value: This research has developed a service-learning model assisted by web-based geotagging that has been implemented to tutoring teachers (write down the implementation process) to facilitate learning services to increase effectiveness and efficiency in serving learning in the community through tutoring.
Psikoedukasi Pencegahan dan Penanganan Sexual Harassment pada Siswa Siswi SMA Negeri 1 Sanga- Sanga
Authors: Myn Einsbie Grata , Helminasari Shorea , Arfan Muhammad Edhil 
Published: March 2024

Pengabdian kepada masyarakat difokuskan terhadap remaja berusia antara 16-17 Tahun pada siswa-siswi SMA Negeri 1 Sanga-Sanga Kelas XII terdiri dari 2 kelas berjumlah 73 siswa dan siswi berjenis kelamin laki-laki dan perempuan di Kabupaten Kutai Kartanegara.metode menggunakan pendekatan psikoedukasi untuk mengenal 4 klasifikasi tindakan pelecehan dan kekerasan seksual : (1) Verbal; (2) Nonverbal; (3) Visual; (4) Physical dan kategori tindakan pelecehan dan kekerasan seksual meliputi: 5 kategori yaitu: (1)Gender Harassment Pelecehan Gender (2)Seductive Behavior Perilaku Menggoda atau Merayu; (3) Sexual Bribery Penyuapan Seksual; (4)Sexual Coercion Pemaksaan Seksual (5)Sexual Assault Penyerangan Seksual. Hasil penyampaian melalui metode psikoedukasi para siswa dan siswi terlibat aktif memahami secara keseluruhan dimana pada prosesi tanya jawab terhadap pengabdi cukup antusias mempelajari serta mengenali perilaku pelecehan seksual secara seksama.
Biodentine Achieves Better Vickers Microhardness and Diametral Tensile Strength When Compared to Glass Ionomer Cement - An Experimental Study
Authors: Qaisar Aneela , Noor Nauman Ahmed , Fareed Muhammad Amber 
Published: March 2024

<p><strong>ABSTRACT</strong></p>
<p><strong>Background and Objective:</strong> Replacing lost dentin with an appropriate substitute has been challenging in recent years. Biodentine and conventional glass ionomers are used as dentin replacement materials. This study aimed to compare the Vickers microhardness (VHN), diametral tensile strength (DTS), and setting time of Biodentine and glass ionomer cement (GIC).<br /><strong>Methods:</strong> This experimental study was conducted in the Department of Science of Dental Materials at Fatima Memorial College of Dentistry, Lahore, in collaboration with the Interdisciplinary Research Centre of Biomedical Materials, COMSATS Lahore from December 2022 to March 2023. A total of fifty disc-shaped samples (4 &times; 2 mm) of Biodentine and GIC Gold Label 2 were fabricated to assess the VHN, DTS, and setting time after immersion in distilled water for 1 hour and after 3 days. Data were analyzed by applying the paired and independent t-tests using Statistical Package for Social Sciences 26.0.<br /><strong>Results:</strong> The mean VHN value of Biodentine and GIC Gold Label 2 cement was 23.4 &plusmn; 1.5 and 17.5 &plusmn; 1.27 after 1 hour and 31.9 &plusmn; 1.66 and 29.6 &plusmn; 1.58 after 3 days, respectively. DTS of Biodentine [7.0 &plusmn; 0.91 mega pascal (MPa)] was significantly greater than GIC Gold label 2 (5.5 &plusmn; 0.68 MPa) after 1 hour (p &lt; 0.05). However, after 3 days, there was a slight increase in the DTS of Biodentine (9.3 &plusmn; 1.53 MPa) while compared to GIC Gold label 2 (8.2 &plusmn; 1.0 MPa) and this difference was not statistically significant (p &gt; 0.05). Biodentine had a higher setting time than GIC Gold label 2, with an initial setting time of 6.7 minutes compared to 2.9 minutes.<br /><strong>Conclusion:</strong> GIC Gold label 2 has a shorter setting time than the but Biodentine which, however, showed higher Vicker&rsquo;s microhardness and DTS. Therefore, Biodentine may be a more suitable substitute for dentine replacement than the GIC Gold label 2.</p>
Fibroadenoma of the Breast Occurring Synchronously in Twin Sisters- A Case Report
Authors: Iqbal Firdous , Gul-e-Rana  
Published: March 2024

<p>Fibroadenomas (FAs) are the most common benign tumors of the breast in young females. Most of the time, it presents as a well-circumscribed, painless, firm to hard, mobile, and slow-growing unilateral or bilateral breast lump. The median age of its presentation is 25 years with rare occurrence after menopause. The exact etiology of FA is still unclear. Unopposed estrogen in the growing breasts of young females is considered as a main factor in its pathogenesis. Family history and development of FA in identical twins are suggestive of genetic contribution to the pathogenesis of these tumors.</p>
<p>This is a case report of young twin sisters who presented at a tertiary care hospital in Lahore with a complaint of a synchronously developed unilateral breast lump. Fine needle aspiration cytology was planned after taking a detailed history and clinical examination of both patients. Diagnosis of FA was confirmed radiologically and through cytological examination. To the best of the authors&rsquo; knowledge, this is the first case of its kind reported from Pakistan.</p>