bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship Between Social Participation and Depressive Symptoms in Patients with Multimorbidity: The Chained Mediating Role of Cognitive Function and Activities of Daily Living
Authors: Ge Huaiju , Dong Shihong , Su Wenyu , Guan Weimin , Yu Qing , Liu Yan , Qi Yuantao , Sun Xialing , Zhang Huiqing , Ma Guifeng 
Published: April 2024

Abstract
Objective: The potential mechanisms linking social participation and depressive symptoms in Chinese individuals with multimorbidity are not yet fully understood. This study aims to explore how cognitive function and activities of daily living (ADLs) mediate the relationship between social participation and depressive symptoms in individuals with multimorbidity.
Methods: We selected 3,782 participants with multimorbidity from the 2018 China Health and Retirement Longitudinal Study. Data related to social participation, cognitive function, ADLs, and depressive symptoms were extracted.
Regression and Bootstrap analysis were used to explore the chained mediating effects of social participation, cognitive function, activities of daily living, and depressive symptoms.
Regression and Bootstrap analyses were used to explore the sequential mediating effects of social participation, cognitive function, ADLs, and depressive symptoms.
Results: Higher levels of social participation (coefficient = −0.2050, p = 0.023), good cognitive function (coefficient = −0.1300, p < 0.001), and good activities of daily living (coefficient = 0.2250, p < 0.001) were significantly associated with lower levels of depressive symptoms. Cognitive function and ADLs were found to have a chained mediating effect between social participation and depressive symptoms (total effect = −0.3530, 95%CI (−0.5314, −0.1746); direct effect = −0.2050, 95%CI (−0.3818, −0.0281); indirect effect = −0.1480, 95%CI (−0.1900, −0.1105)).
Conclusion: A chained mediating effect was found between cognitive function, ADLs, social participation, and depressive symptoms in patients with multimorbidity. Social participation was found to improve the cognitive function of patients with multimorbidity, which in turn enhanced their daily life activities and ultimately alleviated their depressive symptoms.
Potential Threat of Ceratocystis lukuohia on kiwifruit crop
Authors: Cassol Sabrina Angela , Keith Lisa , Pal Chandan , Alfenas Acelino , Alfenas Rafael Ferreira 
Published: April 2024

Abstract

Ceratocystis wilt, caused by Ceratocystis fimbriata, is the most severe disease of the kiwifruit crop in Brazil and represents a threat to other kiwifruit-producing countries where the pathogen has not yet been reported infecting kiwifruit vines. Ceratocystis species have been reported in many countries, some are host specific, while others can infect a wide host range. Given the high impact of the disease on kiwifruit, evaluating whether Ceratocystis isolates from other hosts and countries can also infect kiwifruit is important for implementing biosecurity measures. In the present work, we evaluated if C. lukuohia and C. huliohia, isolated from ohia (Metrosideros polymorpha) in Hawaii are pathogenic to kiwifruit cultivars. Inoculations of both species in rooted cuttings of Monty and Gold3 cultivars showed that C. lukuohia can cause wilt in both kiwifruit cultivars evaluated, with high plant mortality. This is the first report that C. lukuohia can infect another host, demonstrating that it is not host-specific and extends its host range. In addition, considering that C. lukuohia is pathogenic and lethal in kiwifruit vines, kiwifruit-producing areas must implement biosecurity measures to prevent the introduction of this species.
Cost-effectiveness of robot-assisted total hysterectomy for benign pathologies compared to laparoscopic surgery: a retrospective study with propensity score
Authors: Paul-Dehlinger Richard , Vappereau Alexandra , Bras Alicia Le , Oliveira Joana , Favier Amelia , BELGHITI Jeremy , Uzan Catherine , Durand-Zaleski Isabelle , Canlorbe Geoffroy 
Published: April 2024

Abstract

Background
Hysterectomy for benign pathologies is one of the most common gynecological surgeries. In recent years, robotic surgery has become an alternative to traditional surgery, but at a higher cost.
Objective
Estimate the cost of benign robot-assisted hysterectomy for the purpose of supporting public decision-making, as well as the additional cost per major postoperative complication (ClavienDindo score ≥ 3) avoided one month after surgery robotic versus traditional laparoscopic.
Methods
Single-center retrospective study including patients operated on for benign hysterectomy at La Pitié Salpêtrière hospital between January 2016 and December 2019 : 99 by robotic approach, and 86 by laparoscopic approach. Comparison of robotic surgery to laparoscopy. Calculation of a cost-effectiveness ratio (ICER). Use of the propensity score inverse weighting method to ensure comparability of groups.
Results
Robotic surgery has a total cost of € 6,615 at 1 month per patient compared to € 3,859 for laparoscopic surgery with an additional cost of € 377,534 per major postoperative complication avoided, longer operating time and an absence of significant difference in terms of complications and length of hospitalization.
Conclusion
In terms of cost-effectiveness, according to this study, the robot does not appear to be better than laparoscopy. In the years to come, we can expect a development of robotic surgery with rationalization of the practice, with appropriate selection of patients for robotic surgery, development of outpatient surgery and a reduction in the cost of the equipment.
Genetically predicted dietary intake and risks of colorectal cancer: a Mendelian randomisation study
Authors: Hoang Tung , Cho Sooyoung , Choi Ji-Yeob , Kang Daehee , Shin Aesun 
Published: April 2024

Abstract

Background
Effects of confounders on associations between diet and colorectal cancer (CRC) in observational studies can be minimized in Mendelian randomization (MR) approach. This study aimed to investigate observational and genetically predicted associations between dietary intake and CRC using one-sample MR.
Methods
Using genetic data of over 93 million variants, we performed a genome-wide association study to find genomic risk loci associated with dietary intake in participants from the UK Biobank. Then we calculated genetic risk scores of diet-related variants and used them as instrumental variables in the two-stage least square MR framework to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) for associations. We also performed observational analyses using age as a time-scale in Cox proportional hazard models.
Results
Allele scores were calculated from 399 genetic variants associated with the consumption of of red meat, processed meat, poultry, fish, milk, cheese, fruits, vegetables, coffee, tea, and alcohol in participants from the UK Biobank. In MR analysis, genetically predicted fruit intake was significantly associated with a 21% decreased risk of CRC (HR = 0.79, 95% CI = 0.66–0.95), and there was a marginally inverse association between vegetable intake and CRC (HR = 0.85, 95% CI = 0.71–1.02). Weaker associations were observed in multivariable analysis, with HRs (95% CIs) of 0.99 (0.98–1.01) and 0.99 (0.98-1.00) per increment of daily servings of fruits and vegetables, respectively.
Conclusion
Dietary habits were attributable to genetic variations, which can be used as instrumental variables in the MR framework. Our study supported a causal relationship between fruit intake and a decreased risk of CRC and suggested an effective strategy of consuming fruits in the primary prevention of CRC.
In Vitro Digestion and Fecal Fermentation of Polysaccharides from Physalis alkekengi and its Impacts on Human Gut Microbiota
Authors: Zhang Yun , Bai Yuying , Fu Hongyan , Jiang Tianyu , Lv Ge , Zhang Lan , Yu Wenjie , Zhao Lin 
Published: April 2024

Abstract
This study aimed to investigate the effects of in vitro digestion and fermentation of Physalis alkekengi polysaccharides(PAP) and short-chain fatty acids(SCFAs) on the gut microbiome. Human saliva-gastrointestinal digestion and fecal fermentation were simulated in vitro. The results show that the molecular weight of Physalis alkekengi polysaccharides decreased from 8.07×104 to 5.60×104 during saliva-gastroenterization and from 8.07×104 to 1.18×104 after fermentation of feces for 48 hours. During gastric digestion, the level of reducing sugars increased from 0.887 to 1.153 mg/mL. Additionally, a considerable production of free monosaccharides was found during saliva-gastrointestinal digestion. Our data showed that the level of reducing sugars produced by PAPs increased during gastrointestinal digestion. Glucose release decreased with molecular weight, suggesting partial degradation of PAPs during gastrointestinal digestion. Further studies are warranted on the identification of the metabolites generated by polysaccharides from Physalis alkekengi during large intestine fermentation. Some beneficial bacteria, such as genera Bacteroides, Phascolarctobacterium, and Bifidobacterium, significantly increased after digestion and can ameliorate the level of harmful bacteria such as Escherichia-Shigella. These findings suggest that PAPs can alter the composition of gut microbiota and promote the production of beneficial short-chain fatty acids, such as acetic acid, propionic acid, and isovaleric acid.
The Effectiveness of Extract from Ambon Banana Stem Musa cavendishii var. Dwarf paxton for Prevention of Vibrio parahaemolyticus Bacterial Infection in Vannamei Shrimp Litopenaeus vannamei
Authors: Septarisa Geza Intan , Nuryati Sri , Sukenda Sukenda , Yuhana Munti 
Published: April 2024

Abstract

This study aims to evaluate the effect of administering Ambon banana stem extract through feed in enhancing the immune response, growth, and resistance of vannamei shrimp to diseases caused by Vibrio parahaemolyticus bacteria. The research used a completely randomized design consisting of five treatments, namely 2 control treatments (negative control and positive control) and three treatments containing feed with Ambon banana stem extract, namely 0.5 g kg− 1, 0.75 g kg− 1, and 1 g kg− 1 of feed. Shrimp were raised for 30 days and fed five times a day. On the 31st day, shrimp were challenged with V. parahaemolyticus at a dose of 105 CFU mL− 1, except for the negative control. The results showed that the dose of 0.75 g kg− 1 provided significantly higher growth performance (P < 0.05) compared to other doses and controls. Then a dose of 0.75 g kg− 1 was able to increase immune response significantly higher (P < 0.05) than other doses and controls. The bacterial abundance in the intestine at a dose of 0.75 g kg− 1 also significantly suppressed the growth of V. parahaemolyticus (P < 0.05) compared to other doses and controls. In addition, the survival rate of vannamei shrimp at a dose of 0.75 g kg− 1 was significantly higher (P < 0.05) compared to other doses and controls. The results of this research can be used as a reference for the optimal dosage for preventing V. parahaemolyticus bacterial infections using Ambon banana stem extract.
The Epidemiological Profile and Morbidity-Mortality Patterns of Technological Disasters in the Americas from 2000 to 2021: a cross-sectional study
Authors: García Andrea Fernández , Gan Rick Kye , Martínez José Antonio Cernuda , González Pedro Arcos 
Published: April 2024

Abstract

Background
Technological disasters in the Americas have significant public health and environmental implications, but there is limited epidemiological analysis of these events. This study aims to characterize the epidemiological profile of technological disasters in the Americas from 2000 to 2021, focusing on morbidity and mortality trends.
Methods
A retrospective cross-sectional study was conducted. The ANOVA test was applied in the mean rates calculated for each type of disaster. The Mann-Kendall test assessed the presence or absence of temporal trends, and the Dickey-Fuller augmented test was used to determine if the time series were stationary. Predictions were made up to the year 2030 to mean mortality rate per million inhabitants, mean rate of affected individuals per million inhabitants, and mean rate of injuries per million inhabitants.
Results
A total of 733 technological disasters were recorded in the Americas. Statistically significant differences were found between the mean rates of affected individuals and the mean mortality rates per million inhabitants for each type of technological disaster. No trends were identified.
Conclusions
The highest rates of fatalities and affected individuals occurred within industrial accidents.
Integrated high-resolution electrical tomography and drilling cascading investigation of earth-rock dam leakage in a siltstone region: A case study of the Maoshan Reservoir, China
Authors: Xin Yanwen , Gan Jianjun , Liu Fangzhou , Si Zhihang , liu kaijun , tian tao 
Published: April 2024

Abstract

Piping, erosion at the contact of flowing soil, and leaching damage pose a serious leakage risk to earth-rock dams in the siltstone regions. With increasing reservoir operation time, seepage phenomena commonly occur in earth-rock dams, leading to progressively severe damage to the dam body. To understand the distribution of seepage in an earth-rock dam, including its location and magnitude, an imaging analysis of the dam structure is necessary. This involves determining the leakage positions and the underlying reasons. In this study, we conducted a high-resolution electrical resistivity tomography (HERT) investigation to characterize the leakage conditions of the Maoshan Reservoir earth-rock dam in the siltstone area of Jiangxi Province. To enhance the reliability of the HERT data interpretation, drilling, and water pressure tests were employed to validate the interpretations of low-resistivity zones. By applying this cascading survey and analysis method, we obtained spatial variability information on the apparent resistivity of the dam. The resistivity imaging of the entire dam revealed significant variations in apparent resistivity in the study area. Low-resistivity anomalies and high-resistivity anomalies were observed on both the upstream and downstream slopes of the dam. These anomalies represent saturated water channels and impervious bodies, with resistivities less than 200 Ωm and greater than 700 Ωm, respectively. The results of this study indicate that a cascading survey combining HERT and drilling is effective for analyzing the leakage positions of earth-rock dams, providing valuable insights for engineers in implementing effective anti-leakage measures in siltstone area reservoirs.
Prevalence and Associated Factors of Cesarean Section Delivery in Nepal
Authors: Pandit Sudesh , Thasineku Om Chandra , Karki Sujan , Sharma Sushil 
Published: April 2024

Abstract
Introduction Caesarean section delivery plays a crucial role in saving the lives of mother and child. This study assesses the prevalence and associated factors of cesarean section (CS) delivery in the Nepal.
Methods The data used for this study were nationally representative data from the Nepal Demographic and Health Survey 2022. Frequency and cross tabulation, simple logistic regression, and multivariable binary logistic regression analyses for adjusted and unadjusted odd ratios were performed to accomplish the study.
Results In Nepal, the prevalence of CS delivery is 18.2 percent in 2023. The research identifies regional and ethnic disparities, maternal education, wealth index, antenatal visit, place of delivery, and maternal age as significant contributors to the likelihood of CS. Geographical variations, emphasizing higher CS rates in the Terai region and urban areas, and disparities between provinces. The Dalit community exhibits significantly lower rates of CS by ethnic group. Highly educated women showed over a three-fold increase in CS. Wealth disparities reveal a more than sixfold higher likelihood of CS among the wealthiest group compared to the poorest. Extensive antenatal care, a positive indicator of maternal healthcare engagement, is surprisingly associated with heightened CS rates. Private health facilities have a six-time higher CS than public health facilities. Additionally, older maternal age presents a sixfold higher risk of CS.
Conclusion Along with the advancement of society, there seems to be an increase in CS, which is surpassing the World Health Organization's recommended range in Nepal. The study calls for interventions and healthcare policies addressing these multifaceted socio-economic and regional influences on CS rates in Nepal.
Joint K-means clustering and statistical analytical modeling of P- wave velocity and resistivity datasets for subsurface lithologic differentiation
Authors: Dick Mbuotidem David , Bery Andy Anderson , Bala Gabriel Abraham , Akingboye Adedibu Sunny 
Published: April 2024

Abstract

Given the hazards linked to unstable ground conditions, it is vital to grasp the soil-rock characteristics essential for foundation construction and groundwater development. However, the inherent challenges in geophysics, such as the non-uniqueness of the inverse problem and incomplete subsurface knowledge, hinder the direct interpretation of geophysical data in terms of geological units. Traditional soil exploration methods or relying solely on one geophysical survey method often yield inaccurate results due to limitations in mapping subsurface complexities and heterogeneities. This study addresses these challenges by applying K-means cluster analysis to a univariate geophysical parameter set spanning an 800 m section in the geothermally active Kabota-Tawau area of Sabah, Malaysia. Leveraging unsupervised machine learning techniques like principal component analysis, involving Silhouette and elbow methods, the research determines the optimal number of clusters (k) and validates their accuracy. The analysis identifies four distinct lithologic units, serving as proxies for soil/rock properties in the study area. With an R-squared value nearing 1 and an average Silhouette score of 0.67 for \(k=4\), the results indicate a high level of satisfaction in cluster separation, supported by a percentage sum of square error exceeding 88%. This approach enhances our ability to accurately identify lithologic units critical for improving the reliability of foundation construction and groundwater development efforts.
The safety and effectiveness of telemedicine for cancer-related colostomy care in early stage of discharge: A prospective, randomized, single-center study
Authors: Quan Haizhou , Wang Hongqiang , Yang Yu’e , Yu Hongwei 
Published: April 2024

Abstract
Background
There has been an exponential growth in the use of telemedicine services to provide clinical care. However, the safety and effectiveness of telemedicine in cancer-related colostomy care during the early stages of discharge remains unclear. This study aimed to prove that the safety and effectiveness of telemedicine for cancer-related colostomy care are not inferior to those of outpatient care.
Methods
This was a prospective, randomized, noninferiority study. A total of 76 consecutive patients who underwent cancer-related colostomy stoma were enrolled and randomly divided into a telemedicine group or an outpatient group with an equal allocation ratio (1:1). The outpatient group was provided in-person interview mode colostomy care, whereas the telemedicine group was provided video interview mode colostomy care. Using stoma-related complications, self-care ability and quality of life reflected the safety and effectiveness of colostomy care in the early stages of discharge.
Results
The incidence of stoma-related complications within 2-weeks and 1-month after discharge showed no significant differences between the two groups (P2 − weeks = 0.772 and P1 − month = 0.760). The NCI-CTCAE score for stoma-related complications was less than level 2. Patients with complications need not be hospitalized. The ESCA scores were 101.4 ± 13.9 and 106.3 ± 16.5, respectively, in the telemedicine group, and 101.8 ± 13.5 and 103.3 ± 13.4, respectively, in the outpatient group. The C-COH-QOL-OQ scores were 6.15 ± 0.91 and 6.34 ± 0.86, respectively, in the telemedicine group, and 6.27 ± 0.71 and 6.38 ± 0.61, respectively, in the outpatient group. The ESCA and C-COH-QOL-OQ scores were not significantly different between the telemedicine and outpatient group in 2-weeks and 1-month after discharge (all P > 0.05).
Conclusion
The results of this study revealed that the safety and effectiveness of telemedicine for cancer-related colostomy in the early stages of discharge were not inferior to those of outpatient care. When using telemedicine for cancer-related colostomy care, communication between the medical staff and patients is broken through the restrictions of time and place.
Bacterial BEF relationships: degradation metabolic trade-offs with growth rate but not with nitrogen processing pathways
Authors: Teigen Megan , Cuellar-Gempeler Catalina 
Published: April 2024

Abstract

Biodiversity-ecosystem function (BEF) relationships have been a major topic since the 1990’s, increasing in importance due to sustainability and extinction crises. However, the shapes of BEF relationships are not easily correlated with habitat, taxa, or diversity. We propose and test two predictors for BEF relationship shapes: 1) individual species growth rates (as indicative of coexistence and competitive abilities) and functional performance, and 2) BEF shapes of specific functions underlying a broader function.Darlingtonia californicais a carnivorous plant with modified leaves housing bacteria that contribute toward insect prey degradation and nitrogen provision. We isolated 14 distinct bacterial strains from fluid obtained fromD. californica‘s modified leaves. We grew the isolates in monoculture and mixed culture and evaluated each culture using degradation assays, and protein, ammonia, nitrate, chitinase, and protease quantification assays. We ask three specific questions related to our two proposed predictors of BEF shapes: 1) can we predict the function and assembly of a community based on individual species functions? 2) does a species function and growth rate correlate? 3) does degradation overall correlate with other functions in the metabolic processing of nitrogen? We found that increased degradative function was correlated with decreased species growth rates, highly functioning mixed cultures could result from both highly functioning isolates or moderately functioning isolates, and degradative function did not rely on nitrogen processing pathways. Our analysis suggests that BEF relationships present a metabolic trade-off between degradative function and bacterial division rates, but not with nitrogen processing. Additionally, while species with strong functional contributions can also be good competitors, they may also be poor competitors or play complex roles in community assembly.
Combined double-endoscopic treatment of intrauterine device ectopic bladder complicated with bladder calculi: a case report
Authors: Pang Wenyang , Du Zhongbo , Cheng Shulin 
Published: April 2024

Abstract
An intrauterine device (IUD) is a first-line contraceptive regimen recommended by the World Health Organization (WHO) and is widely used worldwide. Ectopic IUD to the bladder associated with bladder stones is rare, and there is no standard treatment. We report here a case of a female patient who presented with hematuria, initially diagnosed with bladder stones, and found intraoperatively that the intrauterine device had migrated to the bladder. We reviewed the literature to analyze possible causes and propose a new feasible minimally invasive surgical protocol.