bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of foundation pit excavation on the internal force of adjacent shield segment structure
Authors: Jiang Y.X. , Wang M. , Feng S. , Li Y.D. , Wang H.L. , Ran L. , Jin T. 
Published: April 2024

Abstract
As subway line density increases, excavation of foundation pits around tunnels unavoidably triggers soil disturbance. This consequently alters the on-site strain and distortion fields of the soil, resulting in internal force modifications in the tunnel shield segment and joint failure. To maintain tunnelling structure safety through numerous foundation pit diggings, this study uses a real-world project as its model. Leveraging the tunnel convergent deformation results derived from prior analyses with PLAXIS 3D software, the Midas GTS software is utilized to explore the alterations in internal forces and joint failure patterns of the tunnel subjected to convergent deformations of 4cm and 5cm. The findings are as follows: (i) Under the effect of a vertical load, the segment deformation takes on a transverse elliptical shape. (ii) The majority of joint failure is primarily focused around the foundation pit excavation area, where the base of the arch opens inwardly, and the midsection of the arch expands outwardly. (iii) The stress on the structure escalates as the extent of foundation pit excavation increases.
Association between ACE1 and missed abortion: ACE1 promotes H2O2-induced trophoblast cell injury in vitro
Authors: Yan Yi-dan , Ji Wen-xia , Zhao Na , Zhang Jian-juan , Du Jie , Lu Ting , Gu Wei-qun 
Published: April 2024

Abstract
The aim of this study was to evaluate the role of angiotensin-converting enzyme 1 (ACE1) in H2O2-induced trophoblast cell injury and the potential molecular mechanisms. Oxidative stress was modeled by exposing HTR-8/SVneo cells to 200 μM H2O2. Western blot and real-time quantitative PCR methods were used to detect protein and mRNA expression level of ACE1 in chorionic villus tissue and trophoblast HTR-8/SVneo cell. Inhibition of ACE1 expression was achieved by transfection with small interfering RNA. Then flow cytometry, Cell Counting Kit-8, and Transwell assay was used to assess apoptosis, viability, and migration ability of the cells. Reactive oxygen species (ROS) were detected by fluorescent probes, and malondialdehyde (MDA), superoxide dismutase (SOD), and reduced glutathione (GSH) activities were determined by corresponding detection kits. Angiotensin-converting enzyme 1 expression was upregulated in chorionic villus tissue of patients with missed abortion (MA) compared with individuals with normal early pregnancy abortion. H2O2 induced elevated ACE1 expression in HTR-8/SVneo cells, promoted apoptosis, and inhibited cell viability and migration. Knockdown of ACE1 expression inhibited H2O2-induced effects to enhance cell viability and migration and suppress apoptosis. Additionally, H2O2 stimulation caused increased levels of ROS and MDA and decreased SOD and GSH activity in the cells, whereas knockdown of ACE1 expression led to opposite changes of these oxidative stress indicators. Moreover, knockdown of ACE1 attenuated the inhibitory effect of H2O2 on the Nrf2/HO-1 pathway. Angiotensin-converting enzyme 1 was associated with MA, and it promoted H2O2-induced injury of trophoblast cells through inhibiting the Nrf2 pathway. Therefore, ACE1 may serve as a potential therapeutic target for MA.
Brittle bonds: queer relationalities in literary and cinematic forms in India
Authors: Mokkil Navaneetha 
Published: April 2024

Abstract
From factories to hostels, homes to neighbourhoods, how do embodied practices in stratified spaces shape the contemporary terrains of queerness in India? In this article, I analyse two recent cultural texts from India, Neeraj Ghaywan’s Geeli Pucchi (Sloppy Kisses, 2021) and Hansda Sowvender Shekhar’s (2018) novel My Father’s Garden, Speaking Tiger Books, Delhi, to engage with the fraught dynamics of relationality and queerness. My analysis contests any easy celebration of community – by foregrounding the movements of dispossessed protagonists who do not fit into the paradigm of the privileged subject of queer politics. Yet these texts capture the fleeting possibilities of reaching towards one another in spaces carved through the operations of exclusion and discrimination. I bring together two texts in which the direct references to sexual identities formed via governmental or non-governmental networks are largely absent; rather, they ask fundamental questions about the in-between terrain of the relational. The dynamics of distance and connection is opened up in complex ways in these cinematic and literary texts as they create imaginative idioms to explore the brittleness of queer bonds formed through the hierarchized operations of class, caste and ethnicity. Through an analysis of the formal aspects of these texts, and the practices of spectatorship and readership they facilitate, I seek to underline how formations of sexuality in India can be unpacked only through a close engagement with the critical discourse on gender, caste and ethnicity.
Queerious communities: building writing centres in Indian universities
Authors: Dasgupta Anannya 
Published: April 2024

Abstract
This paper examines the new phenomenon of writing centres being made a part of universities, particularly the liberal arts private universities, in India, as growing in a way that lends it to consciously choosing queer pedagogy and to building it as a politically queer space. While some aspects of the queering of writing centres mirror the invisibilizing and the burden of proving the worth of their existence in the way queer communities are, other aspects build on what queer theory enables in terms of understanding what it takes to build communities where what is normative will continually shift what it excludes. Queer theory reminds us of the fluid and constantly reconstituting nature of identity formation whether it is based on non-binary gender identity or identities caught in the debilitating intersections of class, caste, religion, ability and sexuality. This has led to a recognition that communities formed around the learning of reading, writing and thinking, as writing centres are, are predisposed to shift focus from product to process as a move in the practice of teaching writing because it considers the individual reading-and-writing-selves present in the classroom as subjects-in-formation. This paper argues that writing pedagogy is creating queer communities because it invites and supports unsettled subjective selves to the process of knowledge production.
Cross-Domain Recommendation To Cold-Start Users Via Categorized Preference Transfer
Authors: Liu Xiaoyang , Fu Xiaoyang , De Meo Pasquale , Fiumara Giacomo 
Published: April 2024

Abstract
Most existing cross-domain recommendation (CDR) systems apply the embedding and mapping idea to tackle the cold-start user problem and, to this end, they learn a common bridge function to transfer the user preferences from the source domain into the target domain. However, sharing a bridge function for all users inevitably leads to biased recommendations. This paper proposes a novel method, named CDR to cold-start users via categorized preference transfer (CDRCPT), to overcome the shortcomings of existing approaches. First, the embeddings of users and items in both the source and target domain are learned through pretraining and we utilize preference encoder to obtain the preference embeddings of users in the source domain. Second, mini-batch clustering is applied in the source domain to group users according to their preferences; here, each cluster identifies a specific class of users, and each cluster is represented by its center. Finally, the general representation is fed into a meta network to learn a bridge function for each available class of users. Experiments on two real data sets show that our CDRCPT method is effective in improving the accuracy and robustness of recommendations.
Deep Learning Model for Tamil Part-of-Speech Tagging
Authors: Visuwalingam Hemakasiny , Sakuntharaj Ratnasingam , Alawatugoda Janaka , Ragel Roshan 
Published: April 2024

Abstract
Part-of-Speech (POS) tagging is one of the popular Natural Language Processing (NLP) tasks. It is also considered to be a preliminary task for other NLP applications such as speech recognition, machine translation, and sentiment analysis. A few works have been published on POS tagging for the Tamil language. However, the performance of the POS tagger with unknown words is not explored in the literature. The appearance of unknown words is a frequently occurring problem in POS tagging and makes it a challenging task. In this paper, we propose a deep learning-based POS tagger for Tamil using Bi-directional Long Short Term Memory (BLSTM). The performance of the POS tagger was evaluated using known and unknown words. The POS tagger with regular word-level embeddings produces 99.83 and 92.46% accuracies for all known and 63.21% unknown words. It clearly shows that the accuracy decreases when the number of unknown words increases. To improve the performance of the POS tagger with unknown words, the proposed BLSTM model that uses word-level, character-level and pre-trained word embeddings. Test results of this model show a 2.57% improvement for 63.21% of unknown words, with an accuracy of 95.03%.
Esophagogastroduodenoscopy findings that do no not explain dysphagia are associated with underutilization of high-resolution manometry
Authors: Pomenti Sydney , Nathanson John , Phipps Meaghan , Aneke-Nash Chino , Katzka David , Freedberg Daniel , Jodorkovsky Daniela 
Published: April 2024

Summary
In patients with dysphagia that is not explained by upper endoscopy, high-resolution esophageal manometry (HRM) is the next logical step in diagnostic testing. This study investigated predictors of failure to refer for HRM after an upper endoscopy that was performed for but did not explain dysphagia. This was a retrospective cohort study of patients &gt;18 years of age who underwent esophagogastroduodenoscopy (EGD) for dysphagia from 2015 to 2021. Patients with EGD findings that explained dysphagia (e.g. esophageal mass, eosinophilic esophagitis, Schatzki ring, etc.) were excluded from the main analyses. The primary outcome was failure to refer for HRM within 1 year of the index non-diagnostic EGD. We also investigated delayed referral for HRM, defined as HRM performed after the median. Multivariable logistic regression modeling was used to identify risk factors that independently predicted failure to refer for HRM, conditioned on the providing endoscopist. Among 2132 patients who underwent EGD for dysphagia, 1240 (58.2%) did not have findings to explain dysphagia on the index EGD. Of these 1240 patients, 148 (11.9%) underwent HRM within 1 year of index EGD. Endoscopic findings (e.g. hiatal hernia, tortuous esophagus, Barrett’s esophagus, surgically altered anatomy not involving the gastroesophageal junction, and esophageal varices) perceived to explain dysphagia were independently associated with failure to refer for HRM (adjusted odds ratio 0.45, 95% confidence interval 0.25–0.80). Of the 148 patients who underwent HRM within 1 year of index EGD, 29.7% were diagnosed with a disorder of esophagogastric junction outflow, 17.6% with a disorder of peristalsis, and 2.0% with both disorders of esophagogastric outflow and peristalsis. The diagnosis made by HRM was similar among those who had incidental EGD findings that were non-diagnostic for dysphagia compared with those who had completely normal EGD findings. Demographic factors including race/ethnicity, insurance type, and income were not associated with failure to refer for HRM or delayed HRM. Patients with dysphagia and endoscopic findings unrelated to dysphagia have a similar prevalence of esophageal motility disorders to those with normal endoscopic examinations, yet these patients are less likely to undergo HRM. Provider education is indicated to increase HRM referral in these patients.
Coronary bypass surgery guided by computed tomography in a low-risk population
Authors: Serruys Patrick W , Kageyama Shigetaka , Pompilio Giulio , Andreini Daniele , Pontone Gianluca , Mushtaq Saima , La Meir Mark , De Mey Johan , Tanaka Kaoru , Doenst Torsten , Teichgräber Ulf , Schneider Ulrich , Puskas John D , Narula Jagat , Gupta Himanshu , Agarwal Vikram , Leipsic Jonathon , Masuda Shinichiro , Kotoku Nozomi , Tsai Tsung-Ying , Garg Scot , Morel Marie-Angele , Onuma Yoshinobu 
Published: April 2024

AbstractBackground and AimsIn patients with three-vessel disease and/or left main disease, selecting revascularization strategy based on coronary computed tomography angiography (CCTA) has a high level of virtual agreement with treatment decisions based on invasive coronary angiography (ICA).MethodsIn this study, coronary artery bypass grafting (CABG) procedures were planned based on CCTA without knowledge of ICA. The CABG strategy was recommended by a central core laboratory assessing the anatomy and functionality of the coronary circulation. The primary feasibility endpoint was the percentage of operations performed without access to the ICA. The primary safety endpoint was graft patency on 30-day follow-up CCTA. Secondary endpoints included topographical adequacy of grafting, major adverse cardiac and cerebrovascular (MACCE), and major bleeding events at 30 days. The study was considered positive if the lower boundary of confidence intervals (CI) for feasibility was ≥75% (NCT04142021).ResultsThe study enrolled 114 patients with a mean (standard deviation) anatomical SYNTAX score and Society of Thoracic Surgery score of 43.6 (15.3) and 0.81 (0.63), respectively. Unblinding ICA was required in one case yielding a feasibility of 99.1% (95% CI 95.2%–100%). The concordance and agreement in revascularization planning between the ICA- and CCTA-Heart Teams was 82.9% with a moderate kappa of 0.58 (95% CI 0.50–0.66) and between the CCTA-Heart Team and actual treatment was 83.7% with a substantial kappa of 0.61 (95% CI 0.53–0.68). The 30-day follow-up CCTA in 102 patients (91.9%) showed an anastomosis patency rate of 92.6%, whilst MACCE was 7.2% and major bleeding 2.7%.ConclusionsCABG guided by CCTA is feasible and has an acceptable safety profile in a selected population of complex coronary artery disease.
Cryocure-VT: the safety and effectiveness of ultra-low-temperature cryoablation of monomorphic ventricular tachycardia in patients with ischaemic and non-ischaemic cardiomyopathies
Authors: Verma Atul , Essebag Vidal , Neuzil Petr , Dyrda Katia , Balt Jippe , Dinov Borislav , Darma Angeliki , Arya Arash , Sacher Frederic , Reddy Vivek Y , Boersma Lucas , Grigorov Ilya , De Potter Tom 
Published: April 2024

Abstract

Aims
The ultra-low-temperature cryoablation (ULTC) ablation system using −196°C N2 cryogen has been reported to create lesions with freeze duration–dependent depth titratable to over 10 mm with minimum attenuation by scar. Cryocure-VT (NCT04893317) was a first-in-human clinical trial evaluating the safety and efficacy of a novel, purpose-built ULTC catheter in endocardial ablation of scar-dependent ventricular tachycardias (VTs).

Methods and results
This prospective, multi-centre study enrolled patients referred for de novo or second ablations of recurrent monomorphic VT of both ischaemic and non-ischaemic aetiologies. Primary safety and efficacy endpoints of the study were freedom from device- or procedure-related major adverse events (MAEs) up to 30 days post-ablation, acute non-inducibility of clinical VTs at the end of the procedure, and freedom from sustained VT or implantable defibrillator intervention at 6 months. Ultra-low-temperature cryoablation was performed in 64 patients (age 67 ± 11 years, 78% ischaemic, ejection fraction = 35 ± 10%) at 9 centres. The primary acute effectiveness endpoint was achieved in 94% (51/54) of patients in whom post-ablation induction was attempted. There were no protocol-defined MAEs; four procedure-related serious adverse events resolved without clinical sequelae. At 6-month follow-up, 38 patients (60.3%) remained VT-free, and freedom from defibrillator shock was 81.0%, with no significant difference between ischaemic and non-ischaemic cohorts. In 47 patients with defibrillator for at least 6 months prior to the ablation, the VT burden was reduced from median of 4, inter-quartile range (IQR, 1–9) to 0, IQR (0–2).

Conclusion
In this first-in-human multi-centre experience, endocardial ULTC ablation of monomorphic VT appears safe and effective in patients with both ischaemic-cardiomyopathy and non-ischaemic-cardiomyopathy.

Clinical Trial Registration
NCT04893317.
Health policy developments in the Western Balkan Countries 2000–19: towards European Health and Health Care Policies
Authors: Arenliu Qosaj Fatime , Bourdeaux Margaret 
Published: April 2024

Abstract

Background
Albania, Bosnia and Herzegovina, Kosovo, Montenegro, North Macedonia and Serbia have committed to becoming European Union (EU) member states. This, among others, implies that candidate/potential candidate states adopt legally authorized EU policies, including health. The study aims to identify the main country-specific health policy areas critical to the EU accession health policy dimension and present the change in associated selected health indicators from 2000 to 2019.

Methods
The study draws on published reports and analyses of official statistics over time and cross-country. Health care policy adherence to the European Commission’s recommended country-specific health actions was classified into five health policy areas: financing, payment, organization, regulation and persuasion. Key health policy areas for Western Balkan countries (WBCs) were identified. Health progress or lack thereof in catching up to the EU15 population health, health expenditure and the number of health professionals are measured.

Results
The European Commission prioritized financing and regulation for all WBCs in the five policy areas. Nine of the 18 analyzed selected health indicators showed divergence, and the other nine converged towards the EU15 averages. WBCs continue to face diverse public health challenges in improving life expectancy at birth, death rates caused by circulatory system diseases, malignant neoplasms, traffic accidents, psychoactive substance use, tuberculosis incidence, tobacco smoking prevalence and public-sector health expenditure.

Conclusions
By 2019, there is limited evidence of WBCs catching up to the average EU15 health levels and health care policies. Closer attention towards EU health and health care policies would be favourable.
Regional differences in stem form between southern and northern red spruce (Picea rubens Sarg.) populations
Authors: Morrone Steven , Green Patrick Corey 
Published: April 2024

Abstract
Red spruce (Picea rubens Sarg.) is a commercially and ecologically important conifer species that primarily exists at northern latitudes of eastern North America and extends southward following the Appalachian Mountains into North Carolina and Tennessee. Due to a warming climate and human-caused disturbances, only fragmented, sky-island populations remain at the highest peaks of the southern Appalachians where their habitat continues to be threatened. While they have been recognized for the rare wildlife habitat they provide in the region, these populations remain understudied. This work aimed to examine differences in stem form between the northern and southern populations of red spruce and to provide additional quantitative methods for managing red spruce stands through providing regionally fitted stem taper models. First, we examined differences in stem form using two methods: a sectional rate of change in diameter and a region variable added to the Kozak (2004) Model 02 taper model. The sectional taper comparison showed significant differences (P &lt; .05) in taper rate throughout the stem that were most pronounced below breast height and above the midpoint. The nested model comparison also showed a significant difference after performing a likelihood ratio test. These results agreed that significant differences in stem form between the two populations exist and supported the idea that localized taper models would provide the best results. Next, we evaluated four stem taper models for their ability to predict upper stem diameters and total volume in southern Appalachian red spruce: a quadratic polynomial, a segmented, a variable exponent, and a geometric model. Fitting data came from a 1992 study across three southern Appalachian spruce-fir sites. Validation data came from a new dataset collected in 2022 at Unaka Mountain, Tennessee. Based on past studies and our results, we found that the Kozak (My last words on taper equations. For Chron 2004;80:507–15. https://doi.org/10.5558/tfc80507-4.) Model 02 variable exponent and the Max and Burkhart (Segmented polynomial regression applied to taper equations. For Sci 1976;22:283–9.) segmented polynomial models performed equally well. The choice of the final model should depend on the users’ objectives and practical limitations (i.e. programming ability, availability of fitting data, error tolerance).
Comprehensive elucidation on the genetic profile of the Hezhou Han population via an efficient InDel panel
Authors: Mei Shuyan , Cui Wei , Chen Man , Cai Meiming , Lei Fanzhang , Wang Xi , Yang Shangwu , Zhu Bofeng 
Published: April 2024

Abstract
The Han nationality is widely distributed in different regions, and it is one of the most populous nationalities in China. Compared with the ethnic minorities in Guangxi Zhuang Autonomous Region, there is relatively less research on Han individuals dwelled in Guangxi as a part of Chinese Han population. In this study, the genetic polymorphisms of 57 autosomal insertion/deletion (InDel) loci were explored in Hezhou Han (HZH) population. Forensic-related parameters revealed that these 57 InDel loci had high forensic validity and could be used in forensic practice application. In addition, the genetic relationships between the HZH population and 30 worldwide reference populations were explored using a variety of analytical methods, such as phylogenetic tree, principal component analysis, and genetic structure analysis. These results demonstrated that there were closer genetic relationships between the HZH and nine populations from East Asia (EAS). The prediction accuracy rates of five inter-continental cross-validation analyses for individuals from EAS was &gt;0.9, and the prediction accuracy rates of three inter-continental cross-validation analyses for individuals from EAS, Europe, and Africa were all &gt;0.95. In addition, 24 of the 57 InDel loci could be served as ancestral information inference loci, which could effectively distinguish individuals of EAS, Europe, and Africa. In conclusion, these InDel loci could be used not only as a good tool for individual identification and paternity testing in HZH population, but also as an auxiliary tool for ancestry information inference research.