bluuebunny/crossref_metadata_2025_split huggingface dataset:
177Lu-DOTATATE Salvage Therapy in Rapidly Progressing Neuroendocrine Tumor With Poor Performance Status
Authors: Aggarwal Piyush , Kumar Ajay , Sood Ashwani , Walia Rama , Bhadada Sanjay Kumar , Mittal Bhagwant Rai 
Published: March 2024

Abstract
Peptide receptor radionuclide therapy (PRRT) has shown to be effective and safe in metastatic gastroenteropancreatic and nongastroenteropancreatic neuroendocrine tumors. However, the selection criteria for PRRT are restricted to patients with good performance status (Eastern Cooperative Oncology Group score ≤2 or Karnofsky performance score ≥60). This denies many patients with adequate somatostatin receptor expression and biochemical profiles from the beneficial effects of PRRT on the quality of life, daily function, and overall survival. The 2 cases highlight the favorable response of PRRT in patients with metastatic neuroendocrine tumor having a very poor performance status initially.
The importance of host physical niches for the stability of gut microbiome composition
Authors: Ludington William B. 
Published: March 2024

Gut bacteria are prevalent throughout the Metazoa and form complex microbial communities associated with food breakdown, nutrient provision and disease prevention. How hosts acquire and maintain a consistent bacterial flora remains mysterious even in the best-studied animals, including humans, mice, fishes, squid, bugs, worms and flies. This essay visits the evidence that hosts have co-evolved relationships with specific bacteria and that some of these relationships are supported by specialized physical niches that select, sequester and maintain microbial symbionts. Genetics approaches could uncover the mechanisms for recruiting and maintaining the stable and consistent members of the microbiome.
This article is part of the theme issue ‘Sculpting the microbiome: how host factors determine and respond to microbial colonization’.
Drosophila melanogasterSet8 and L(3)mbt function in gene expression independently of histone H4 lysine 20 methylation
Authors: Crain Aaron T. , Butler Megan B. , Hill Christina A. , Huynh Mai , McGinty Robert K. , Duronio Robert J. 
Published: March 2024

AbstractMono-methylation of Lysine 20 of histone H4 (H4K20me1) is catalyzed by Set8 and thought to play important roles in many aspects of genome function that are mediated by H4K20me-binding proteins. We interrogated this model in a developing animal by comparing in parallel the transcriptomes ofSet8null,H4K20R/A, andl(3)mbtmutantDrosophila melanogaster. We found that the gene expression profiles ofH4K20AandH4K20Rlarvae are markedly different thanSet8nulllarvae despite similar reductions in H4K20me1.Set8nullmutant cells have a severely disrupted transcriptome and fail to proliferatein vivo, but these phenotypes are not recapitulated by mutation ofH4K20indicating that the developmental defects of Set8nullanimals are largely due to H4K20me1-independent effects on gene expression. Further, the H4K20me1 binding protein L(3)mbt is recruited to the transcription start sites of most genes independently of H4K20me even though genes bound by L(3)mbt have high levels of H4K20me1. Moreover, both Set8 and L(3)mbt bind to purified H4K20R nucleosomes in vitro. We conclude that gene expression changes inSet8nullandH4K20mutants cannot be explained by loss of H4K20me1 or L(3)mbt binding to chromatin, and therefore that H4K20me1 does not play a large role in gene expression.
A HIV-1 Gp41 Peptide-Liposome Vaccine Elicits Neutralizing Epitope-Targeted Antibody Responses in Healthy Individuals
Authors: Erdmann Nathan B. , Williams Wilton B. , Walsh Stephen R. , Grunenberg Nicole , Edlefsen Paul T. , Goepfert Paul A. , Cain Derek W. , Cohen Kristen W. , Maenza Janine , Mayer Kenneth H. , Van Tieu Hong , Sobieszczyk Magdalena E. , Swann Edith , Lu Huiyin , De Rosa Stephen C. , Sagawa Zachary , Anthony Moody M. , Fox Christopher B. , Ferrari Guido , Edwards R.J. , Acharya Priyamvada , Munir Alam S. , Parks Robert , Barr Margaret , Tomaras Georgia D. , Montefiori David C. , Gilbert Peter B. , Juliana McElrath M. , Corey Lawrence , Haynes Barton F. , Baden Lindsey R. ,   NIAID HVTN 133 Study Group
Published: March 2024

AbstractBackgroundHIV-1 vaccine development is a global health priority. Broadly neutralizing antibodies (bnAbs) which target the HIV-1 gp41 membrane-proximal external region (MPER) have some of the highest neutralization breadth. An MPER peptide-liposome vaccine has been found to expand bnAb precursors in monkeys.MethodsThe HVTN133 phase 1 clinical trial (NCT03934541) studied the MPER-peptide liposome immunogen in 24 HIV-1 seronegative individuals. Participants were recruited between 15 July 2019 and 18 October 2019 and were randomized in a dose-escalation design to either 500 mcg or 2000 mcg of the MPER-peptide liposome or placebo. Four intramuscular injections were planned at months 0, 2, 6, and 12.ResultsThe trial was stopped prematurely due to an anaphylaxis reaction in one participant ultimately attributed to vaccine-associated polyethylene glycol. The immunogen induced robust immune responses, including MPER+ serum and blood CD4+ T-cell responses in 95% and 100% of vaccinees, respectively, and 35% (7/20) of vaccine recipients had blood IgG memory B cells with MPER-bnAb binding phenotype. Affinity purification of plasma MPER+ IgG demonstrated tier 2 HIV-1 neutralizing activity in two of five participants after 3 immunizations.ConclusionsMPER-peptide liposomes induced gp41 serum neutralizing epitope-targeted antibodies and memory B-cell responses in humans despite the early termination of the study. These results suggest that the MPER region is a promising target for a candidate HIV vaccine.Trial Registrationhttp://www.clinicaltrials.gov/Identifier:NCT03934541
Viral challenges and adaptations between Central Arctic Ocean and atmosphere
Authors: Rahlff Janina , Westmeijer George , Weissenbach Julia , Antson Alfred , Holmfeldt Karin 
Published: March 2024

AbstractAquatic viruses act as key players in shaping microbial communities. In polar environments, they face significant challenges like limited host availability and harsh conditions. However, due to restricted ecosystem accessibility, our understanding of viral diversity, abundance, adaptations, and host interactions remains limited. To fill this knowledge gap, we studied viruses from atmosphere-close aquatic ecosystems in the Central Arctic and Northern Greenland. Aquatic samples for virus-host analysis were collected from ~60 cm depth and the submillimeter surface microlayer (SML) during the Synoptic Arctic Survey 2021 on icebreaker Oden in Arctic summer. Water was sampled from a melt pond and open water before undergoing size-fractioned filtration and followed by genome-resolved metagenomic and cultivation investigations. The prokaryotic diversity in the melt pond was considerably lower compared to open water. The melt pond was dominated by a Flavobacterium sp. andAquilunasp., the latter having a relatively small genome size of 1.2 Mb and the metabolic potential to generate ATP using the phosphate acetyltransferase-acetate kinase pathway. Viral diversity on the host fraction (0.2 – 5 µm) of the melt pond was strikingly limited compared to open water. From 1154 dereplicated viral operational taxonomic units (vOTUs), of which two-thirds were predicted bacteriophages, 17.2% encoded for auxiliary metabolic genes (AMGs) with metabolic functions. Some AMGs like glycerol-3-phosphate cytidylyltransferase and ice-binding like proteins might serve cryoprotection of the host. Prophages were often associated with SML genomes, and two active prophages of a new viral genera from the Arctic SML strainLeeuwenhoekiella aequoreaArc30 were induced. We found evidence that vOTU abundance in the SML compared to ~60 cm depth was more positively correlated to the distribution of a vOTU across five different Arctic stations. The results indicate that viruses employ elaborated strategies to endure in extreme and host-limited environments. Moreover, our observations suggest that the immediate air-sea interface serves as a platform for viral distribution in the Central Arctic.
Cytokine expression patterns predict suppression of vulnerable neural circuits in a mouse model of Alzheimer’s disease
Authors: Chan Dennis C. , Kim ChaeMin , Kang Rachel Y. , Kuhn Madison K. , Beidler Lynne M. , Zhang Nanyin , Proctor Elizabeth A. 
Published: March 2024

AbstractAlzheimer’s disease is a neurodegenerative disorder characterized by progressive amyloid plaque accumulation, tau tangle formation, neuroimmune dysregulation, synapse an neuron loss, and changes in neural circuit activation that lead to cognitive decline and dementia. Early molecular and cellular disease-instigating events occur 20 or more years prior to presentation of symptoms, making them difficult to study, and for many years amyloid-β, the aggregating peptide seeding amyloid plaques, was thought to be the toxic factor responsible for cognitive deficit. However, strategies targeting amyloid-β aggregation and deposition have largely failed to produce safe and effective therapies, and amyloid plaque levels poorly correlate with cognitive outcomes. However, a role still exists for amyloid-β in the variation in an individual’s immune response to early, soluble forms of aggregates, and the downstream consequences of this immune response for aberrant cellular behaviors and creation of a detrimental tissue environment that harms neuron health and causes changes in neural circuit activation. Here, we perform functional magnetic resonance imaging of awake, unanesthetized Alzheimer’s disease mice to map changes in functional connectivity over the course of disease progression, in comparison to wild-type littermates. In these same individual animals, we spatiotemporally profile the immune milieu by measuring cytokines, chemokines, and growth factors across various brain regions and over the course of disease progression from pre-pathology through established cognitive deficit. We identify specific signatures of immune activation predicting hyperactivity followed by suppression of intra- and then inter-regional functional connectivity in multiple disease-relevant brain regions, following the pattern of spread of amyloid pathology.
Naa80 is required for actin N-terminal acetylation and normal hearing in zebrafish
Authors: Ree Rasmus , Lin Sheng-Jia , Sti Dahl Lars Ole , Huang Kevin , Petree Cassidy , Varshney Gaurav K. , Arnesen Thomas 
Published: March 2024

AbstractActin is a key component of the cytoskeleton of eukaryotic cells and is involved in numerous cellular functions. In animal cells, actins are uniquely N-terminally processed by a dedicated enzyme machinery to generate their mature acidic and acetylated forms. The final step of this maturation process involves N-terminal acetylation, a reaction catalyzed by NAA80 in humans. In human cell lines, N-terminal acetylation of actin plays a crucial role in maintaining normal cytoskeletal dynamics and cell motility. The physiological impact of actin N-terminal acetylation remains to be defined. Here, we developed a zebrafishnaa80knockout model and established that zNaa80 acetylates both muscle and non-muscle actinsin vivo. Ourin vitroinvestigation of purified zNaa80 unveiled a clear preference for acetylating N-termini derived from actins. Interestingly, zebrafish lacking actin N-terminal acetylation were viable and exhibited normal development, morphology and behaviour. In contrast, human individuals carrying pathogenic actin variants may present with hypotonia and hearing impairment. While zebrafish depleted fornaa80did not display any obvious muscle defects or abnormal muscle tissue, we found that they have abnormal inner ear development such as small otoliths and impaired response to sound stimuli. In sum, we have defined that zebrafish Naa80 N-terminally acetylates actinsin vitroandin vivoand that actin N-terminal acetylation is essential for normal hearingin vivo.
High-power test results for a cylindrical-shell silicon carbide higher-order-mode damper
Authors: Xu Wencan , Conway Z. A. , Daly E. , Guo J. , Hernandez K. , Holmes D. , Rimmer R. A. , Severino F. , Smith K. , Weiss D. , Zaltsman A. 
Published: March 2024

The next high-current Electron-Ion Collider (EIC) is a new accelerator to be built at Brookhaven National Laboratory in collaboration with Thomas Jefferson National Accelerator Facility. In the EIC Electron Storage Ring (ESR), there will be beam currents of up to 2.5 A, which will excite massive higher-order-mode (HOM) power in the 17 single-cell 591 MHz superconducting radio-frequency (SRF) cavities. Damping the HOM power in the ESR SRF cavities is a challenge. A room temperature cylindrical shell shape silicon carbide (SiC) beamline HOM absorber (BLA) was chosen as the baseline design, due to its broadband and high-power capability, and previous demonstrations at other accelerator facilities, albeit at much lower power. Because the EIC BLA HOM power dissipation is significantly greater than the previous applications, it is imperative to carry out high-power testing to determine the maximum device performance levels achievable for thermal transport, rf breakdown, and mechanical stress, prior to finalizing the design. A SiC HOM absorber with a state-of-the-art geometry size was prototyped to verify the shrink-fit technique, test outgassing rate, and high-power handling capability. This paper presents the HOM damper’s prototyping and test results.

Published by the American Physical Society
2024
Social influencer spillover effects under cap-and-trade and carbon tax regulation: the choice between marketplace or reseller mode
Authors: Wu Jie , Guo Nan , Chen Zhixin , Ji Xiang 
Published: March 2024

PurposeThe purpose of this paper is to analyze manufacturers' production decisions and governments' low-carbon policies in the context of influencer spillover effects.Design/methodology/approachThis paper investigates the impact of the social influencer spillover effect on manufacturers' production decisions when they collaborate with intermediary platforms to sell products through marketplace or reseller modes. Game theory and static numerical comparison are used to analyze our models.FindingsFirstly, under low-carbon policies, the spillover effect does not always benefit manufacturer profits and changes non-monotonically with an increasing spillover effect. Secondly, in cases where there are both a carbon emission constraint and a spillover effect present, if either the manufacturer or intermediary platform holds a strong position, then marketplace mode benefits manufacturer profits. Thirdly, regardless of business mode used when environmental damage coefficient is high for products; government should implement cap-and-trade regulation to optimize social welfare while reducing manufacturers’ carbon emissions.Practical implicationsThis study offers theoretical and practical research support to assist manufacturers in optimizing production decisions for compliance with carbon emission limits, enhancing profits through the development of effective influencer marketing strategies, and providing strategies to mitigate carbon emissions and enhance social welfare while sustaining manufacturing activities.Originality/valueThis paper addresses the limitations of prior research by examining how the social influencer spillover effect influences manufacturers' business mode choices under government low-carbon policies and analyzing the social welfare of different carbon emission restrictions when such spillovers occur. Our findings provide valuable insights for manufacturers in selecting optimal marketing strategies and business modes and decision-makers in implementing effective regulations.
Comparing the determinants of household carbon footprints between rural and urban: evidence from China household survey data
Authors: Lv Jinwei , Liu Bing , Chai Li 
Published: March 2024

PurposeUrbanization is driving the growth of China’s carbon footprint. It’s important to investigate what factors, how and to what extent, affect carbon footprints embedded in various categories of rural and urban households’ consumption.Design/methodology/approachWe employ an environmental extended input-output model to assess and compare the rural-urban household carbon footprints and perform a multivariant regression analysis to identify the varying relationships of the determinants on rural and urban household carbon footprints based on the panel data of Chinese households from 2012 to 2018.FindingsThe results show evidence of urbanity density effect on direct carbon footprints and countervailing effect on indirect carbon footprints. The old dependency ratio has no significant effect on rural family emissions but has a significantly negative effect on urban direct and indirect carbon footprints. A higher child dependency ratio is associated with less rural household carbon emissions while the opposite is true for urban households. Taking advantage of recycled fuel saves direct carbon emissions and this green lifestyle benefits urban households more by saving more carbon emissions. There is a positive relationship between consumption structure ratio and direct carbon footprints while a negative relationship with indirect carbon footprints and this impact is less significant for urban households. The higher the price level of water, electricity and fuel, the lower the rural household’s direct carbon footprints. Private car ownership consistently augments household carbon footprints across rural and urban areas.Originality/valueThis paper provides comprehensive findings to understand the relationships between an array of determinants and China’s rural-urban carbon emissions, empowering China’s contribution to the global effort on climate mitigation.
The (un)sustainable mix: supply chain finance, sustainability ratings and liquidity
Authors: Gelsomino Luca Mattia , Olde Riekerink Kim , Medina Elisa , Bortolotti Thomas 
Published: March 2024

Purpose
This study aims to investigate the interaction effect between offering supply chain finance (SCF) programmes and sustainability ratings on the liquidity performance of buyers and suppliers.

Design/methodology/approach
The study uses a unique sample of buyers that each have an SCF programme. The sample is complemented with financial information and sustainability scores. The data is analysed through a random effects model.

Findings
Aligning with recent advances in SCF literature, the results confirm a tendency for SCF programmes to favour buyers over suppliers. However, the relationship between SCF programme adoption and liquidity performance for buyers and suppliers is positively moderated by the strong sustainability performance of both parties.

Practical implications
Buyers and suppliers are advised to implement and adopt effective SCF programmes that are beneficial for both parties. For buyers, the authors suggest leveraging on SCF programmes as incentives to foster sustainable behaviour among suppliers. For suppliers, the authors recommend caution before joining programmes offered by buyers that do not perform well on sustainability.

Social implications
Enhancing sustainability within global supply chains and fostering favourable payment practices towards suppliers are crucial for policy development and regulation. The findings clarify the connection between both components, offering valuable insights for policymakers in this domain.

Originality/value
The study is built on a manually picked, unique database of buyers offering SCF programmes to their suppliers. This allows, across a large sample, an evaluation of the differences between buyers that offer SCF programmes and those that do not.
Conceptualization and measurement of owner BIM capabilities: from a project owner organization perspective
Authors: Pan Pengcheng , Wang Yu , Yang Yumiao , Zhang Sujuan 
Published: March 2024

PurposeBuilding Information Modeling (BIM) capabilities have been studied at the individual, project, organizational, and even industry levels to ensure the realization of BIM value in the architectural, engineering, construction, and operation industry. However, limited research has focused on a project owner organization perspective to investigate owner BIM capabilities that are required to ensure effective project management and delivery. This present study aims to propose an indicator framework to evaluate owner BIM capabilities at the organizational level.Design/methodology/approachLeveraging the existing literature on BIM capabilities and synthesizing insights from the resource-based view and information technology capabilities research, this study conceptualizes the BIM capabilities of project owner organizations and offers a framework of indicators for measurement. Semi-structured interviews with BIM experts and a questionnaire survey were conducted to identify key indicators affecting owner BIM capabilities. A six-dimensional structural equation model with 29 indicators was then established.FindingsThe findings highlight the multidimensionality of owner BIM capabilities and show that process capabilities play a crucial role in enhancing owner BIM capabilities, while technical capabilities are considered as the least important aspect.Research limitations/implicationsThe study sheds light on the key role of project owner organizations in ensuring BIM value and suggests that project owners focus more on the organizational processes of introducing BIM in managing projects.Originality/valueThis study reconceptualizes owner BIM capabilities drawing on the idea of resource-based view and information technology capabilities and highlights the important dimensions and indicators of owner BIM capabilities at the organizational level.
The mourning after affirmative action: a composite counterstory about whiteness as property, fugitive pedagogy, and possibility
Authors: Jayakumar Uma Mazyck 
Published: March 2024

PurposeIn the aftermath of the Supreme Court’s 2023 decision to effectively end race-conscious admissions practices across the nation, this paper highlights the law’s commitment to whiteness and antiblackness, invites us to mourn and to connect to possibility.Design/methodology/approachDrawing from the theoretical contributions of Cheryl Harris, Jarvis Givens and Chezare Warren, as well as the wisdom of Justice Ketanji Brown Jackson’s dissenting opinion, this paper utilizes CRT composite counterstory methodology to illuminate the antiblack reality of facially “race-neutral” admissions.FindingsBy manifesting the impossible situation that SFFA and the Supreme Court’s majority seek to normalize, the composite counterstory illuminates how Justice Jackson’s hypothetical enacts a fugitive pedagogy within a dominant legal system committed to whiteness as property; invites us to mourn, to connect to possibility and to remain committed to freedom as an intergenerational project that is inherently humanizing.Originality/valueIn a sobering moment where we face the end of race-conscious admissions, this paper uniquely grapples with the contradictions of affirmative action as minimally effective while also radically disruptive.