bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serum Uric Acid and Achievement in High School
Authors: Montoye Henry J. , Mikkelsen William M. 
Published: February 2007

AbstractThe relationship of serum uric acid concentration and school achievement was studied in 467 high school children in Tecumseh, Michigan. Serum uric acid (SUA) was determined by the spectrophotometric method. No statistically significant relationships were found between SUA and intelligence quotient or average academic grades. There was also no significant difference in SUA among the overachievers (higher grade point average than predicted by IQ) as compared to the underachievers.
Regional Migratory Osteoporosis
Authors: Gupta Ramesh C. , Popovtzer Mordecai M. , Huffer William E. , Smyth Charley J. 
Published: February 2007

AbstractAn additional case of regional migratory osteoporosis is described in a 54‐ year‐old male who had involvement of his right and left knees and left foot one after the other, each lasting for 7 to 9 months. Additional features observed in this case and not described previously in the literature were associated transient proximal muscle wasting, acrocyanosis, hyperhydrosis and tremors of both hands. A detailed bone biopsy from osteoporotic site is reported.
Antibodies to Viral and Synthetic Double‐Stranded RNA in Discoid Lupus Erythematosus
Authors: Sylvester Robert A. , Attias Moises , Talal Norman , Tuffanelli Denny L. 
Published: February 2007

AbstractAntibodies to reovirus double‐stranded RNA (3H‐reovirus RNA) were demonstrated in 23 of 54 sera (42%) of patients with discoid lupus erythematosus (DLE) and 35 of 50 sera (70%) of patients with systemic lupus erythematosus (SLE) using a cellulose ester filter radioimmunoassay. The incidence of antibodies to 3H‐reovirus RNA was 10% in psoriasis, 14% in rheumatoid arthritis, 19% in Sjogren's syndrome and 4% in normal controls. Inhibition studies performed on SLE and DLE sera showed that the anti‐RNA antibodies had similar specificities. These results suggest that DLE may be part of the SLE spectrum.
Serologic Abnormalities in Systemic Lupus Erythematosus Associated with Viral Hepatitis and Tuberculosis
Authors: Salisbury Kent W. , Plotz Paul H. , Holland Paul V. , Steinberg Alfred D. , Peppercorn Mark 
Published: February 2007

AbstractA 38‐year‐old Turkish woman with the clinical diagnosis of systemic lupus erythematosus but with negative LE cell tests developed a positive LE cell test and anti‐DNA and anti‐RNA antibodies coincident to manifestations of serum hepatitis. Tuberculosis, present at the same time, may have been an additional factor.
Uridine Incorporation into the Media and RNA of Cultured Rheumatoid Synovial Cells
Authors: Grayzel Arthur I. 
Published: February 2007

AbstractThe incorporation of 3H‐uridine into the media and RNA of rheumatoid synovial cell cultures, with and without pretreatment with 5‐bromo‐deoxyuridine (BUDR) and Actinomycin D, has been examined by sucrose density gradient centrifugation without providing evidence for the presence of an infectious agent within these cells.
Local and Generalized Shwartzman Reaction Induced in Rats with 6‐Sulfanilamidoindazole Arthritis
Authors: Ward John R. , Miller Morgan L. , Burch Frank 
Published: February 2007

AbstractRats fed 6‐SAI show a marked increase of plasma fibrinogen. After IV endotoxin, there was a precipitous fall in the circulating leukocyte count, followed by a marked decrease in the plasma fibrinogen level and death. The time of death of the rats corresponded to the rapid fall of plasma fibrinogen. Histologically these animals demonstrate: 1) fibrin deposits in the glomerular capillaries, Bowman's space, and small veins of the kidneys; 2) fibrin deposition in the septal capillaries and veins of the lungs; 3) fibrin deposition in the portal veins, sinusoids, and central veins of the liver with marked hepatic congestion; 4) splenic congestion with hemorrhagic disruption of the follicles and fibrin deposition in a circumferential fashion about the follicles; and 5) marked edema, dilation, and engorgement of the subcutaneous and periarticular veins of the hindpaws with prominent hemorrhage into these areas. Fibrin deposits in veins and tissues of the paws was also observed. Thus, it appears that 6‐SAI arthritis simultaneously prepares the rat for both the generalized and localized Shwartzman reaction.
Fenoprofen ®calcium in rheumatoid arthritis. a controlled double‐blind crossover evaluation
Authors: Fries James F. , Britton Melvin C. 
Published: February 2007

AbstractFenoprofen Calcium (Lilly, Compound 69323) is a new nonsteroidal analgesic and antiinflammatory drug proposed for the treatment of rheumatoid arthritis and allied conditions. In a controlled double‐blind crossover study comparing 6 weeks of Fenoprofen therapy with 6 weeks of treatment with high‐dose acetylsalicylic acid, the aspirin proved minimally more effective and substantially more toxic. Nine of 27 patients found Fenoprofen equal to aspirin, and 6 preferred it. Twelve patients preferred aspirin. The safety of the drug suggested by animal studies appears to be confirmed by these short‐term studies in relatively small numbers of patients. It appears likely that Fenoprofen will provide a useful, although not dramatic, additional agent with which to manage the patient with rheumatoid arthritis.
The effect of low oxygen concentration on growth, glycolysis, and sulfate incorporation by articular chondrocytes in monolayer culture
Authors: Marcus Ralph E. , Sokoloff Leon 
Published: February 2007

AbstractRadiosulfate incorporation, DNA synthesis, and glycoiysis by rabbit articular chondrocytes and skin fibrocytes in monolayer culture were compared under different concentrations of oxygen (19, 6.8, 1.3, and 0.6%). Cell for cell, chondrocytes under each condition had higher levels of radiosulfate incorporation and glycolysis than did fibrocytes. Growth of the fibrocytes was reduced approximately 20% when the oxygen concentration was reduced to 6.8%, but that of chondrocytes was unaffected. A progressive Pasteur effect was observed with both cell types. Radiosulfate incorporation was reduced at low oxygen concentrations. The findings in this cell culture system are thus at variance with other published evidence that hypoxia is a major histogenetic force favoring chondrogenic expression.
Destructive polyarthritis secondary to mycobacterium kansasii
Authors: Girard Donald E. , Bagby Grover C. , Walsh John R. 
Published: February 2007

AbstractA 42‐year‐old patient is reported in whom Mycobacterium kansasii pulmonary infection preceded the development of arthritis secondary to hematogenous spread. Contributing factors included systemic lupus erythematosus and corticosteroid therapy. Further, we present evidence that in M. kansasii infections, pulmonary lesions may precede extrapulmonary disease; hematogenous spread of infection likely represents the route through which joint disease evolves; previous damage to the joint whether from intrinsic disease as in rheumatoid arthritis, or extrinsic disease as in trauma, may be necessary for the development of infectious arthritis; and lastly, dissemination often represents opportunistic infection in patients who are immunologically compromised.
A search for viruses and mycoplasmas in connective tissue diseases
Authors: Person Donald A. , Sharp John T. , Rawls William E. 
Published: February 2007

AbstractTaking advantage of the distinctive buoyant densities of viral and mycoplasmal nucleic acids, methods were developed for detecting a noncytolytic virus or mycoplasma in synovial cell cultures. No evidence of viral or mycoplasmal infection was found in the study of 20 cell strains derived from 13 patients with rheumatoid arthritis, 3 patients with noninflammatory joint disease, and one patient each with Reiter's syndrome, Behcet's syndrome, vasculitis with hepatitis 6 antigenemia, and ankylosing spondylitis with peripheral arthritis. Further, neither the treatment of synovial‐VERO cocultured cells with 5‐iodo‐2'‐deoxyuridine in dimethyl sulfoxide nor radiolabeling at the time of explanation permitted the detection of a virus or mycoplasma.
A fatal case of Reiter's disease complicated by amyloidosis
Authors: Caughey David E. , Wakem Christopher J. 
Published: February 2007

AbstractThe clinical course of an 18‐year‐old boy with Reiter's disease is described. Diarrhea occurred at times, as did occasional melena. Remission occurred after 6 months, but 3 months later, following a severe relapse involving the skin, the joints, and the bowel, paralytic ileus developed, and at laparotomy colectomy was performed. On the sixth postoperative day he died. The postmortem findings were of bronchopneumonia and widespread amyloidosis, including involvement of the bowel.
Ochronotic arthropathy with calcium pyrophosphate crystal deposition a light and electron microscopic study
Authors: Reginato Antonio J. , Ralph Schumacher H. , Martinez Virginia A. 
Published: February 2007

AbstractSynovial fluid from a patient with ochronotic arthropathy and calcification of the capsule of the right knee contained calcium pyrophosphate crystals and dark debris. Microscopic examination of an unstained fresh preparation showed these dark fragments to have a brown or golden brown color typical of ochronotic pigment. By electron microscopy there were identifiable cartilage fragments in the synovial fluid. These contained clumps of dense material deposited on the surface of collagen fibers. Similar brown staining and electron dense material probably representing ochronotic pigment was seen in synovial membrane and synovial fluid cells. Some of the intracellular calcium pyrophosphate crystals were in close relation with probable pigment.
Adult onset juvenile rheumatoid arthritis
Authors: Aptekar Robert G. , Decker John L. , Bujak Joseph S. , Wolff Sheldon M. 
Published: February 2007

AbstractThe term “juvenile rheumatoid arthritis” (JRA) is used to designate a chronic polyarthritic process of onset in childhood. Discussion of the possibility of an adult form of JRA is revived. Fifteen patients who are believed to have JRA are described briefly; they are notable for the fact that their disease began after age 16.
Filter radioimmunoassay for antibodies to reovirus rna in systemic lupus erythematosus
Authors: Attias Moises R. , Sylvester Robert A. , Talal Norman 
Published: February 2007

AbstractAntibodies binding reovirus RNA (3H‐reovirus RNA) were demonstrated in 35 of 50 sera (70%) from patients with systemic lupus erythematosus (SLE) and in 22 of 29 sera (76%) from New Zealand hybrid mice (NZB/NZW F1) using a cellulose ester filter radioimmunoassay. By contrast, they were present in only 19% of 69 patients with Sjögren's syndrome, 14% of 21 patients with rheumatoid arthritis and 4% of 88 normal adult controls. This assay method will also measure antibodies to DNA and synthetic RNA and depends on entrapment of radioactive nucleic acid immune complexes on the filter. Serial studies in three patients treated with a stable dose of corticosteroids demonstrated similar binding and specificity over several years of disease.
Lipid synovial effusion unique occurrence in systemic lupus erythematosus
Authors: Ryan William E. , Ellefson Ralph D. , Emmerson Ward L. 
Published: February 2007

AbstractA patient who had systemic lupus erythematosus developed an acute synovitis symptomatically resembling septic arthritis: however, the synovial effusion was chylous, a unique occurrence. Significant differences, quantitatively and qualitatively, between the lipids of the blood and those of the synovial fluid suggested the possibility of synthesis of the lipids in synovial tissues.
Development of reticulum cell sarcoma during cyclophosphamide therapy
Authors: Tannenbaum Hyman , Schur Peter H. 
Published: February 2007

AbstractA 55‐year‐old woman with a clinical picture of deforming rheumatoid arthritis associated with serologic and histologic evidence of systemic lupus erythematosus (SLE) is described. After 14 months of therapy with cyclophosphamide and prednisone, disseminated reticulum cell sarcoma was discovered.
Parameters of improvement in patients with rheumatoid arthritis treated with cyclophosphamide
Authors: Hurd E. R. , Ziff M. 
Published: February 2007

AbstractNine patients with rheumatoid arthritis were treated with cyclophosphamide. A significant decrease in joint score was seen in 8 patients after 2 months of treatment. At this time there were significant decreases in the monocyte and small lymphocyte counts. Leukopenia was not observed nor were significant changes in other common laboratory parameters observed at this time. Significant decreases in immunoglobulin levels occurred only after 10 months of treatment. Total depletion of small lymphocytes occurred in 7 of 9 patients at 33 weeks. These findings suggest that improvement on cyclophosphamide may be related to decreases in circulating small lymphocytes and monocytes and that levels of these cells in blood rather than the development of leukopenia be used as a guide to dosage.
Adenocarcinoma of the lung during azathioprine therapy
Authors: McAdam Lawrence , Paulus Harold E. , Peter James B. 
Published: February 2007

AbstractReports of malignancies developing during immunosuppressive therapy have been difficult to interpret because of concurrent prednisone administration in all cases, and organ transplantation in most. This communication reports an adenocarcinoma of the lung in a 39‐year‐old woman with lupus nephritis who had been treated only with azathioprine during the previous 4 years. This suggests that corticosteroids and transplanted antigens may not be prerequisites for the development of a malignancy during immunosuppressive therapy.
In vitro peripheral blood and synovial fluid lymphocyte interactions
Authors: Griffiths Marie M. , Williams Ralph C. 
Published: February 2007

AbstractIn vitro interaction of autologous peripheral blood and synovial fluid lymphocytes was studied using cells isolated from patients with various forms of arthritis. Addition of mitomycin‐treated peripheral blood lymphocytes from patients with inflammatory arthritis to in vitro cultures of autologous synovial fluid lymphocytes caused an increased incorporation of tritiated thymidine by the synovial fluid lymphocytes. However when the reverse situation was tested, no stimulation of peripheral blood lymphocytes by mitomycin‐treated synovial cells was recorded. In some instances synovial fluid lymphocytes were observed to exert an apparent cytotoxic or inhibitory effect on autologous peripheral blood lymphocytes. The latter response pattern was found to occur to a much greater degree with lymphocyte preparations from patients with rheumatoid arthritis than in those with other forms of inflammatory joint disease.
Serum levels of C1q, C1r and C1s in normal and pathologic sera
Authors: M de E de Bracco María , Manni Jorge A 
Published: February 2007

AbstractC1q, C1r and C1s protein concentrations were simultaneously assayed in sera of patients with systemic lupus erythematosus (SLE), rheumatoid arthritis, autoimmune hemolytic anemia, and viral hemorrhagic fever as well as in healthy adult control subjects. Correlation coefficients between the three subunits of C1 were calculated and the sequential evolution of C1q, C1r, and C1s levels was studied in patients with SLE. In the majority of cases there was a good correlation between C1q, C1r, and C1s; subunit levels increased or decreased in a coordinated fashion. A marked discrepancy between C1q, C1r, and C1s serum concentration was observed in 3 instances. Low C1q coexisted with extremely high C1r and C1s values. It appears that C1r and C1s are closely linked while C1q may vary in a more independent way.
Favorable outcome in diffuse proliferative glomerulonephritis of systemic lupus erythematosus
Authors: Epstein Wallace V. , Grausz Henry 
Published: February 2007

AbstractLife table analysis of 31 patients with biopsy proven diffuse proliferative glomerulonephritis due to Systemic Lupus Erythematosus reveals a 77.7% five‐year survival. Patients with similar lesions have, in the past, had an approximate 20% five‐year survival. The improved survival is attributed to the combined use of prednisone and chlorambucil and a panel of frequently repeated laboratory tests that provides a guide to the activity of the systemic disease.
Urinary fibrin split products in lupus nephritis. Correlation with other parameters of renal disease
Authors: Marchesi S. L. , Aptekar R. G. , Steinberg A. D. , Gralnick H. R. , Decker J. L. 
Published: February 2007

AbstractA total of 337 measurements of urinary fibrin(ogen) split products (FDP) have been made over a 2‐year period on 56 patients with lupus nephritis. Nineteen patients were studied during a 14 week controlled trial of cytoxic drug therapy and the remaining patients were studied at random intervals. An attempt was made to correlate FDP excretion levels with accepted parameters of renal disease and of lupus activity. While patients with significant nephritis by other criteria excreted elevated levels of FDP when compared with normal individuals or patients with rheumatoid arthritis, the excretion by individual patients fluctuated markedly in sequential measurements. In addition FDP excretion correlated poorly with BUN, creatinine clearance, and protein excretion, and with indicators of lupus activity (C3 and anti‐DNA levels). We conclude that although fibrin deposition in the glomerulus is almost certainly an important factor in the pathogenesis of lupus nephritis, urinary FDP levels are not helpful in assessing the progress of glomerular damage in individual patients.
Preliminary experience with cell culture of human articular chondrocytes
Authors: Srivastava Vishwa M. L. , Malemud Charles J. , Hough Aubrey J. , Bland John H. , Sokoloff Leon 
Published: February 2007

AbstractArticular Chondrocytes from 14 human amputation specimens were grown in monolayer culture. The joint cartilages appeared normal grossly. The ages of the patients ranged from 13 to 62 years. The cells grew slowly and did not thrive in subculture. Vitamin C increased DNA synthesis by the Chondrocytes but decreased incorporation of radiosulfate into mucopolysaccharides. Whole articular cartilage from a 30 year old man showed a great heterogeneity of mucopolysaccharides. In addition to the expected chondroitin sulfates 4 and 6 and keratan sulfate, appreciable quantities of hyaluronate, chondroitin, disulfated chondroitin and dermatan sulfate were found (4.0%, 1.5%, 25.5% and 1.3% of the total mucopolysaccharides respectively). The same compounds were secreted into the medium by the cultured Chondrocytes but in distorted proportions. These and other findings differ greatly from those obtained with rabbit Chondrocytes which grow readily under the same conditions and recapitulate quite faithfully the mucopolysaccharide synthesis occurring in whole cartilage.
Bacteriolytic and bactericidal activity of sera and synovial fluids in rheumatoid arthritis and in osteoarthritis
Authors: Pruzanski W. , Leers W. D. , Wardlaw A. C. 
Published: February 2007

AbstractBacteriolytic and bactericidal activity was evaluated in sera and synovial fluids of 28 patients with rheumatoid arthritis and 13 patients with osteoarthritis. An attempt was made to correlate the results with the concentrations of the total hemolytic complement, lysozyme, immunoglobulins, transferrin, and the titer of the Latex fixation. Bacteriolytic activity in all but 5 hypocomplementemic rheumatoid sera and in all osteoarthritic sera was normal. There was a correlation (P = 0.01) between bacteriolytic activity and the level of complement, but not the level of other factors or the titer of the Latex fixation. Bacteriolytic activity in the rheumatoid and osteoarthritic synovial fluids was low, being respectively four times and two times weaker than in the corresponding sera. It correlated well only with the level of complement (P < 0.01). Bactericidal activity of rheumatoid and osteoarthritic sera was normal but was very significantly decreased in the synovial fluids, being respectively 10 times weaker and four times weaker than in the corresponding sera. The only positive correlation was found between bactericidal activity and the complement level (P < 0.01). There was no correlation between the titer of the Latex fixation and the level of the total hemolytic complement either in serum or in synovial fluids. The influence of 6 antiarthritic drugs on antibacterial activity was tested by addition of drugs to the normal human serum. There was no change in bacteriolytic activity, however bacterial growth was inhibited when high concentrations of drugs were mixed with the culture medium.
Effects of cyclophosphamide on B‐ and T‐lymphocytes in rheumatoid arthritis
Authors: Clements P. J. , Yu D. T. Y. , Levy J. , Paulus H. E. , Barnett E. V. 
Published: February 2007

AbstractThe characteristics of circulating blood lymphocytes in 16 patients with rheumatoid arthritis (RA) on cyclophosphamide (CPA) were compared with 49 control RA patients and 70 normal volunteers. In all three groups the percentages of B‐ and T‐lymphocytes were the same. In untreated RA the absolute numbers of B‐ and T‐lymphocytes were lower than normal. During CPA therapy the absolute numbers of B‐ and T‐lymphocytes decreased markedly while the mean lymphocyte diameter increased significantly. The profound effects of CPA therapy on both B‐ and T‐lymphocytes may be related to the concomitant marked depression in humoral and cell‐mediated immunity seen during CPA therapy.
Spontaneous carditis in the NZB mouse and its hybrids
Authors: Pansky Ben , Freimer Earl H. 
Published: February 2007

AbstractThe NZB mouse and its NZB/NZW hybrid spontaneously develop carditis as they age. This carditis is characterized by an inflammatory process that includes pancarditis, valvulitis and arteritis. Anitschkow cells are present in many areas of inflammation. In some areas there are discrete lesions similar to Aschoff bodies.
The association of antinuclear antibodies with the chronic iridocyclitis of juvenile rheumatoid arthritis (Still's disease)
Authors: Schaller Jane Green , Johnson Gerald D. , Holborow Eric J. , Ansell Barbara M. , Smiley W. K. 
Published: February 2007

AbstractPositive tests for antinuclear antibodies (ANA) were found in 51 of 58 (88%) patients with chronic iridocyclitis and juvenile rheumatoid arthritis (Still's disease). Antinuclear antibodies were predominantly of the IgG class of immunoglobulins and were generally present in liters of 1:50 (six ANA units) or more. They were unassociated with disease activity, severity or duration, age of patient at onset or testing, or sex. Neither other autoantibodies nor antibodies reactive with DNA or RNA were associated. In 8 patients tested early in disease, ANA were found prior to the onset of iridocyclitis. The presence of ANA should prove useful in identifying patients with JRA at risk for chronic iridocyclitis. In contrast, negative tests for ANA in patients with childhood‐onset arthritis and iridocyclitis were found to be associated with acute iridocyclitis and subsequent ankylosing spondylitis.
Heterogeneity of RNA protein antigens reactive with sera of patients with systemic lupus erythematosus description of a cytoplasmic nonribosomal antigen
Authors: Mattioli Martha , Reichlin Morris 
Published: February 2007

AbstractA soluble cytoplasmic RNA protein antigen (La) is described, which precipitates with sera of patients with systemic lupus erythematosus and a small number of patients who lack antinuclear factors but who have various connective tissue symptoms. Antibodies to the cytoplasmic RNA protein are almost invariably (8 of 9 cases) accompanied by antibodies to a non‐nucleic acid cytoplasmic antigen, Ro. Description of this antigen enlarges the spectrum of nucleic acid antigens reactive with the sera of patients with systemic lupus erythematosus.