bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self-Care and Community Care by Indian Women: Materiality and Time Use
Authors: Sen Ruchira , Rajeshwari T.S. Kavita 
Published: April 2024

Abstract
Self-care is an aspect of social reproduction— the basis of a sustainable economy. Every day, we produce ourselves —by brushing our teeth, bathing, and asking ourselves how we feel. As women (and other care workers) produce themselves, they are revitalized to offer care to those around them, whether at home or in the market economy. However, the market economy understands self-care in individualistic ways, imagining it as a way to brand wellness products. Poet and activist Audre Lorde (1980) critiques the market economy's understanding of self-care. Lorde presents a self-affirming idea of self-care—to take the time to understand how one's body feels versus how it looks. In this paper, we inquire —do married, working Indian women undergo self-care? We analyze data from the Time Use Survey of 2019 and inquire how much time do married working Indian women spend on i) personal care and the maintenance of their bodies, ii) leisure and iii) community care and iv) private prayer, which we define as self-care. Our study shows that married working Indian women spend 97 minutes a day on average less than married working men on self-care. Here, self-care includes sleeping, eating and personal hygiene, where the gender gap of married working population is at 45 minutes a day. We estimate the effects of demographic variables and paid and unpaid work on time spent in self-care by men and women through a simultaneous equation model. Through this, we trace the relationship between classical Indian patriarchy and the materiality of self-care.
Glycated haemoglobin: a biomarker of the life expectancy of Parkinson’s disease patients with type 2 diabetes
Authors: Dai Yinghong , Wang Zheng , Wang Yijing , Zhu Yixiao , Yi Yan , Li Meng , Peng Qiyuan , Li Jinchen , Guan Ying , Zhao Guihu , Li Bin 
Published: April 2024

Abstract

Type 2 diabetes (T2D) elevates Parkinson's disease (PD) risk, yet Hemoglobin A1c (HbA1c) implications on PD survival are unclear. This study assessed HbA1c's influence on PD survival. PD patients from the UK Biobank were divided into T2D-PD and nonT2D-PD groups. Adjusting for age, sex, townsend deprivation index, and body mass index, Cox regression analysis revealed that T2D-PD patients with HbA1c ≥ 43.1 mmol/mol had an increased mortality risk. No significant difference in mortality rates was observed between T2D-PD patients with HbA1c < 43.1 mmol/mol and nonT2D-PD patients. HbA1c may serve as a survival biomarker for T2D-PD patients.
Degradation evolution and mechanism of sheet molding compound with variable composition exposed to acid solution environment
Authors: Li Jian , Fu Chao , Ming Ruifeng , Shi Minxian , Dong Wenhao , Guo Jiang , Guo Xingkui , Pan Duo , Zhu Xiufang , Alshammari Dalal A. , Melhi Saad , Li Mufang , Thabet Hamdy Khamees 
Published: April 2024

Abstract

In the present work, the sheet molding compound (SMC) composites with variable filler, resin and fiber composition were prepared to investigate the effects of composition on acid resistance of SMC composites. The water absorption of SMC composites with various compositions was measured to estimate the influence of water on mechanical properties deterioration. Hardness and flexural properties tests were performed to investigate the degradation evolution. The degradation mechanism was revealed by analyzing the change of molecule configuration and evaluating the thermal stability. A minimum reduction of the flexural strength (3.21%) was observed on the SMC composites with 11.3 wt% hollow glass microspheres (HGMs). The chemical resistance and addition amount of the fillers had significant impacts on the acid resistance of SMC composites. A great flexural property and a minor degradation of flexural strength (6.29%) and modulus (7.86%) was obtained in SMC composites with the mixed resin. The resin characteristics, molecules weight, free volume size and polar groups number, had an important impact on the water absorption and acid resistance of SMC composites. A high flexural property and minor degradation of flexural strength (5.12%) and modulus (7.66%) was observed in SMC composites with 55 wt% glass fibers (GFs). Exposed to 25 ℃, 20 wt% sulfuric acid solution for 28 days, the SMC composites exhibited a minor degradation of HGMs and GFs. In this condition, the deterioration of mechanical properties was dominated by the resin matrix plasticization and decomposition, along with the interface degradation. It can be concluded that the original defects and weak interacted regions in the composites system initiated the degradation of SMC composites, while the microstructure and composition of SMC composites dominated the degradation progress.
RETRACTED: Development and application of a rapid screening method for Rodentibacter heylii and Rodentibacter pneumotropicus in laboratory animals
Authors: Yan Huiqiong , Chen Sisi , Xing Jing , Feng Yufang , Fang Jie , Du Jiangtao , Zhou Shasang , Guo Honggang , Jin Xiaoyin , Wang Zhiyuan , Tao Junhao , Lu Lingqun , Kong Qingming , Ying Huazhong , Han Wei , Dai Fangwei 
Published: April 2024

Abstract
The authors have requested that this preprint be removed from Research Square.
Effects of wearing a KF94 face mask on performance, perceptual, and physiological responses during a resistance exercise
Authors: Ji Minje , Lee Dohyeon , Lee Sewon 
Published: April 2024

Abstract
Wearing a face mask in indoor public places including fitness centers is an effective strategy to prevent the airborne transmission of COVID-19. However, only a few studies have been performed on wearing a mask during resistance exercise (RE) which is primarily performed in indoor fitness centers. This study aimed to investigate the effects of wearing a KF94 mask on exercise volume, perceptual parameters, and physiological responses during RE. Twenty young men participated in this randomized crossover trial. Participants performed moderate-intensity (1RM 60%) RE sessions in two different conditions (KF94 mask vs. no mask). Cardiorespiratory parameters, exercise volume, rating of perceived exertion (RPE), and dyspnea were measured during RE. Blood lactate concentration, blood pressure, arterial stiffness, and perceptual parameters were measured at pre-exercise and post-exercise. Exercise volume, ventilation volume, and ventilation efficiency parameters were lower with the KF94 mask than without the mask. However, RPE and dyspnea were higher with the KF94 mask than without the mask. Central arterial stiffness at post-exercise was higher with the KF94 mask than without the mask. Therefore, wearing a KF94 mask during RE affects exercise volume, perceptual parameters, and physiological responses, suggesting coaches need to modify RE manipulation variables while wearing a KF94 mask.
Placental T2* as a measure of placental function across field strengths: Normal values from 0.55T to 3T.
Authors: Hall Megan , Verdera Jordina Aviles , Cromb Daniel , Silva Sara Neves , Rutherford Mary , Counsell Serena , Hajnal Joseph , Story Lisa , Hutter Jana 
Published: April 2024

Abstract

Placental MRI is increasingly implemented in clinical obstetrics and research. Functional imaging, especially T2*, has been shown to vary across gestation and in pathology. Translation into the clinical arena has been slow because of time taken to mask the region of interest and owing to differences in T2* results depending on field strength. This paper contributes methodology to remove these barriers by utilising data from 0.55, 1.5 and 3T MRI to provide a fully automated segmentation tool; determining field strength dependency of placental assessment techniques; and deriving normal ranges for T2* by gestational age but independent of field strength. T2* datasets were acquired across field strengths. Automatic quantification including fully automatic masking was achieved and tested in 270 datasets across fields. Normal curves for quantitative placental mean T2*, volume and other derived measurements were obtained in 273 fetal MRI scans and z-scores calculated. The fully automatic segmentation achieved excellent quantification results (Dice scores of 0.807 at 3T, 0.796 at 1.5T and 0.815 at 0.55T.). Similar changes were seen between placental T2* and gestational age across all three field strengths (p < 0.05). Z-scores were generated. This study provides confidence in the translatability of T2* trends across field strengths in fetal imaging.
Public Awareness and Precautionary Measures for Disease Transmission Prevention: A Microbial Evaluation of Ethiopian Paper Currency in Circulation in Arba Minch Town, SNNPR
Authors: Delisho Fitsum Dejene , Gorfu Saron Dereje , Yambo Dinka Ejeta , Yahiya Yonas Syraji 
Published: April 2024

Abstract

Background
Money bills are handled by the public every day, which means they can carry microorganisms that can be passed from person to person through direct contact. This study aims to assess the public awareness and evaluate the bacterial contamination on Ethiopian paper currency in circulation in Arba Minch Town, SNNPR, Ethiopia.
Methods
A cross-sectional study was conducted at the microbiology and parasitology laboratory at Arba Minch University, Ethiopia. A total of 150 Ethiopian paper currency samples were collected aseptically from different sectors in Arba Minch town for microbial analysis.
Results
The most common microorganisms isolated from the samples were gram-positive bacteria, with yeast being the least common. These microorganisms were identified as klebissela spp, E. coli, Streptococcus spp, Bacillus spp, Aspergillus spp, and Staphylococcus aureus based on their characteristics observed through phenotypic, microscopic, and biochemical analysis. The antimicrobial susceptibility patterns of Staphylococcus aureus and Streptococcus spp. were evaluated, and both showed higher sensitivity to Vancomycin and Tetracycline antibiotics. Similarly, Klebsiella spp showed higher sensitivity to Ciprofloxacin while exhibiting a lower sensitivity rate (6.6667%) to Ampicillin. In contrast, Ampicillin showed higher activity on the E. coli isolates. Regarding the transmission of diseases through paper currency, a significant majority of participants (79.8%) were aware of the associated risk. However, it is worth noting that more than half of the participants (53.9%) reported that they do not take any precautions after handling paper currency.
Conclusion
Overall, the study confirms that paper bills are a suitable environment for bacterial growth and could potentially contribute to infections. Therefore, it emphasizes the importance of raising awareness about the potential risks associated with mishandling paper currency in all food establishments.
Prognostic Significance of CD133 Expression in Breast Cancer: Correlation with the Nottingham Prognostic Index
Authors: rustamadji Primariadewi , wiyarta Elvan 
Published: April 2024

Abstract

Background
CD133 is a transmembrane protein, identified as a cancer stem cell marker, and its prognostic significance in various malignancies, including breast cancer, has been studied. This study aims to investigate the prognostic significance of CD133 expression in breast cancer and its correlation with the Nottingham Prognostic Index (NPI).
Methods
This retrospective cohort study examined specimens from female patients diagnosed with Invasive Breast Cancer (IBC). CD133 expression was evaluated using the H-score based on staining intensity. Patient data such as age, tumor dimensions, Nottingham Prognostic Index, and other clinicopathological parameters were collected. Comparative univariate analysis and correlation analysis were performed.
Results
Our study included 60 patients, with significant differences in CD133 H-score values were observed among lymphovascular invasion (LVI) patients (p < 0.001), patients with metastasis (p < 0.001), and patients with NPI (p = 0.005). There was a significant positive correlation between CD133 H-score and NPI (r: 0.31; p0.014) and also between NPI and tumor size (r: 0.66; p0.001).
Conclusion
Our findings suggest that CD133 may serve as a prognostic marker in breast cancer, with higher expression levels linked to more aggressive disease characteristics and a poorer prognosis as indicated by NPI.
Synthesis and cytotoxic evaluation of ester analogues of (-)-curine
Authors: Chokchaisiri Suwadee , Kumjun Sittisak , Thepmalee Chutamas , Rukachaisirikul Thitima 
Published: April 2024

Abstract

This study presents the synthesis and cytotoxic evaluation of ester analogues derived from (-)-curine, a natural compound isolated from the roots of Cissampelos pareira (Menispermaceae). The synthesis involved the preparation of mono- and di-acetylcurine, along with four other ester derivatives, through diverse chemical transformations. Structural characterization of the synthesized compounds was performed using spectroscopic techniques and high-resolution mass spectrometry. Cytotoxicity assessments were conducted across various cancer cell lines, including MCF-7, MDA-MB-231, and Huh-7, as well as non-cancerous HEK293T cells, utilizing the MTT assay. Notably, compounds 4 and 5 demonstrated significant cytotoxic activities superior to the parent compound 1 and even matched or exceeded the cytotoxic effects induced by cisplatin, a conventional chemotherapeutic agent, across all tested cancer cell lines. These findings highlight the potential of compounds 4 and 5 as promising candidates for further development as potent cytotoxic agents in cancer therapy.
Unprecedented TPE-Embedded Butterfly Bis-Crown Ether with Controllable Conformation and Supramolecular Chiroptical Property
Authors: Hu Xiao-Yu , Tian Xueqi , Zuo Minzan , Shen Yuhong , Mao Ni , Wang Kaiya , Sheng Yanshan , Velmurugan Krishnasamy , Jiao Jianmin , Niemeyer Jochen 
Published: April 2024

Abstract

Understanding how subtle structural differences between macrocyclic conformational isomers impact their properties and separation has garnered increasing attention in the field of supramolecular synthetic chemistry. In this work, a series of tetraphenylene (TPE)-embedded butterfly bis-crown ether macrocycles (BCE[n], n = 4-7), comprising two crown ether side rings and a TPE core, were synthesized through intramolecular McMurry coupling. Unexpectedly, the presence of flexible oligoethylene chains with varying lengths were found to influence molecular conformation via intramolecular interactions, resulting in the formation of two stabilized conformers with specific semi-rigid symmetric/asymmetric structures (sym-BCE[n] and asym-BCE[n], n = 5, 6). Moreover, it is noteworthy that neither symmetric nor asymmetric conformers are present in the more rigid BCE[4] or the more flexible BCE[7]. Interestingly, these conformers display distinct fluorescence properties and host-guest binding abilities, and only sym-BCE[5] can serve as a host for chiral polymer binding, resulting in the formation of chiral supramolecular assemblies through host-guest interaction induced chirality. Moreover, both circular dichroism (CD) and circularly polarized luminescence (CPL) signals of the obtained assemblies could be switched off by the addition of sodium ion (Na+), suggesting potential applications in the field of dynamic chiral materials.
Effect of fluidization in increasing the run-out distance of granular flows generated from different aspect ratio collapsing columns
Authors: Aravena Alvaro , Chupin Laurent , Dubois Thierry , Roche Olivier 
Published: April 2024

Abstract
We investigate the propagation dynamics of fluidized granular flows in a horizontal channel in order to evaluate the factors controlling the efficiency of fluidization in increasing the run-out distance of natural granular mixtures such as pyroclastic density currents. For this, we use a two-phase numerical model able to simulate dam-break experiments, which permits us to describe depth-dependent variations of flow properties and the effect of pore pressure on the rheology of the granular material. We show that the interplay between column collapse timescale and flow front velocity plays a primary role in determining the effective influence of fluidization on run-out distance. For high aspect ratio columns, collapse velocity decreases abruptly after reaching its peak, a significant portion of the collapse occurs when the flow front has travelled a long distance from the reservoir and, importantly, the decrease of basal pore pressure with time in the reservoir translates into a reduced velocity of the granular material entering into the propagation channel during final phases of collapse. Thus, at some point, the collapsing material is not able to affect significantly the flow front dynamics, in contrast to low aspect ratio collapsing columns. These results are consistent with complementary analogue experiments, which show that the granular material at the front of the deposit originates from lower levels of the collapsed column. Comparison with new experimental data also reveals that the effective pore pressure diffusion coefficient is an increasing function of column height, and can be considered as proportional to a weighted average of flow thickness during propagation. This is consistent with experiments on static defluidization columns, but had not been tested in dam-break experiments until this study. Considering this type of dependency, under our experimental and simulation conditions, the non-dimensional run-out distance presents a relative maximum for an aspect ratio between \(1\) and \(2\), and then it decreases abruptly. Our observations suggest that the effect of fluidization in increasing run-out distance is limited under conditions of sudden collapse of a volume of fluidized material with no initial velocity, such as collapsing domes. This has implications for the long-lasting debate on the influence of fluidization in the transport dynamics of natural granular flows.
IGF2-reprogrammed macrophages ameliorate the inflammatory response and protects against the neurodegenerative and neuroinflammatory process in Parkinson`s disease models.
Authors: Grunenwald Felipe , Huerta Tomas Javier , Sepulveda Denisse , Jerez Carolina , Urbina Valentina Belén , Diaz-Espinoza Rodrigo , Nova Esteban , Pacheco Rodrigo , Martín-Montañez Elisa , Gil-Rodriguez Sara , Valverde Nadia , Garcia-Fernandez María , Aguilera Carlos , Chana-Cu Pedro PhD , Vidal Rene Luis 
Published: April 2024

Abstract
Background: Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the Substantia Nigra, which causes motor deficits. The most common histopathological feature of PD is the presence of α-synuclein (α-syn) misfolding protein and neurotoxic accumulations which leads to neuronal loss. Additionally, the inflammatory response arises as a relevant factor engage in modulate the neurodegeneration process in PD. An increase of proinflammatory cytokines in the blood and brain samples has been reported in PD patients. Also, peripheral blood T cells recognized α-syn, triggering a chronic inflammation in the blood and brain tissue in PD.
IGF2 signaling has been involved on cellular reprogramming of macrophages to anti-inflammatory phenotype by epigenetic changes. Moreover, recently a decrease of IGF2 levels was reported in blood samples from PD patients.
Methods: The inflammatory response was analyzed by flow cytometry, and qPCR in PBMCs from Chilean PD patients and macrophages isolated from α-syn overexpression transgenic mouse (ASO). We evaluated the motor impairment, systemic inflammation, neurodegeneration, α-syn accumulation and microglial activation in ASO mice treated via intravenous with IGF2-reprogrammed macrophages (MIGF2).
Results: We showed a significant increase of proinflammatory markers in PBMCs from PD patients. Also, IGF2 prevented the proinflammatory phenotype triggered by exposure to α-syn PFF in murine primary macrophages. Furthermore, MIGF2 treatment significant decrease the motor impairment, systemic inflammation, and reduce neurodegeneration, α-syn accumulation and microglial activation levels in Substancia Nigra brain region during disease progression in ASO mice.
Conclusions: PBMCs from Chilean PD patients showed an increase in proinflammatory profile. Additionally, MIGF2 has a neuroprotective effect in-vitro and in-vivo PD model. MIGF2 prevents motor impairment, neurodegeneration, and inflammation in the brain tissue of ASO mice in different stages of disease progression, suggesting its further application as a possible treatment for PD patients.
Development of a Machine-learning Based Diagnosis Procedure to Distinguish Aortic Dissection from Non-ST- Elevation Myocardial Infarction
Authors: Huang Min , Lin Long , Fan Xiaoxuan , Wu Yinge 
Published: April 2024

Abstract

Background:Similar symptoms have been observed in Non-ST elevation myocardial infarction (NSTEMI) and aortic dissection (AD), making diagnosis challenging. Recognizing the distinction between them is essential for prompt treatment. This study was to establish a model based on machine learning (ML) to improve diagnosis accuracy; (2) Methods: 353 individuals' clinical characteristics and laboratory results (193 AD, 160 NSTEMI) were analyzed. The Least Absolute Shrinkage and Selection Operator (LASSO) regression analysis was used to identify significant indicators. Four ML models were constructed, and the Voting algorithm was used to conduct an ensemble analysis. Decision Curve Analysis (DCA) assessed the clinical value. And collected a new validation set of 36 AD and 48 NSTEMI patients to assess the generalizability of the optimal model. Shapley Additive explanations (SHAP) was used to evaluate feature contribution; (3) Results: With an accuracy of 92%, recall of 94%, F1-score of 91.43%, and an AUC of 0.95 (95CI%: 0.91-0.99) on the test set, the ensemble Voting model was recognized as the optimal model. DCA provided evidence of the model's clinical value in AD prediction. The SHAP indicated that Troponin T and D-dimer were crucial predictors; (4) Conclusions: We successfully established a machine-learning based diagnosis approach for timely distinguish of AD and NSTEMI. Based on our results, the Voting model performed the best in terms of predicting efficacy. In addition, we used SHAP to provide a personalized risk assessment for the development of the prediction results. This diagnosis model may assist the emergency department to quickly avoiding misdiagnosis of AD with NSTEMI. This research involving biomedical studies on human subjects was conducted in accordance with the principles outlined in the Declaration of Helsinki. The study protocol and informed consent procedures were reviewed and approved by the Institutional Ethics Committee. The approval reference number for this study is B-2023-060.