bluuebunny/crossref_metadata_2025_split huggingface dataset:
Regulation and function of foxe3 during early zebrafish development
Authors: Swindell Eric C. , Zilinski Carolyn A. , Hashimoto Ryuju , Shah Rina , Lane Mary Ellen , Jamrich Milan 
Published: March 2008

AbstractIn this article, we investigate the expression, regulation, and function of the zebrafish forkhead gene foxe3. In wild type embryos, foxe3 is first expressed in a crescent‐shaped area at the anterior end of the prechordal plate, corresponding to the polster. At later stages, the hatching gland, the lens, and the anterior pituitary express this gene. Using morpholinos against the zinc finger Kruppel‐like factor 4 (KLF4) we show that foxe3 is regulated differently in the polster and in the lens. In the absence of KLF4, expression of foxe3 in the polster is not activated, whereas in the lens placode the expression of KLF4 is not required for the transcription of foxe3. The expression of foxe3 is also regulated by the hedgehog and nodal signaling pathways. foxe3 expression is altered in the hedgehog pathway mutants iguana and you‐too and the nodal pathway mutant cyclops. foxe3 function is necessary for the execution of lens‐specific gene expression and lens morphogenesis, as the knockdown of foxe3 results in a loss of platelet‐derived growth factor receptor alpha (pdgfrα) expression and in the vacuolization of the lens. 46:177–183, 2008. © 2008 Wiley‐Liss, Inc.
Speciation of magnesium in rat plasma using capillary electrophoresis‐inductively coupled plasma‐atomic emission spectrometry
Authors: Deng Biyang , Li Xianfeng , Zhu Pingchuan , Xu Xiangshu , Xu Qiumei , Kang Yanhui 
Published: March 2008

AbstractA new method for speciation analysis of magnesium species and quantification of free magnesium concentrations in rat plasma was developed by on‐line coupling of CE with inductively coupled plasma‐atomic emission spectrometry (ICP‐AES). Baseline separation of seven magnesium species was achieved by using a 120 cm (100 μm internal diameter) fused‐silica capillary, a 20 kV separation voltage and a solution of 50 mmol/L NaAc‐HAc (pH 5.5) as electrolyte buffer. CE‐ICP‐AES analysis of a rat plasma sample showed the presence of seven magnesium species, one of which was identified as free Mg2+ ion by spiking a Mg2+ standard; the migration time of the Mg2+ peak in the standard and the spiked sample matched with each other. One protein‐bound magnesium species in rat plasma is associated with albumin, and the other three species are combined with globulin. The concentration of free magnesium in the plasma was 14.0 mg/L. The other six magnesium species were estimated to be 4–15 mg/L. RSDs of migration time and peak area for the magnesium species from ten replicates were less than 5%. The developed method was also applied to speciation analysis of magnesium species in spiked plasma samples. The recoveries of the free magnesium species in four samples ranged from 95.8 to 103.8%.
High‐dose‐rate brachytherapy plus neck dissection for nodal disease
Authors: Beitler Jonathan J. , Garg Madhur , Owen Randall P. , Sarta Catherine , Smith Richard V. , Yaparpalvi Ravindra 
Published: March 2008

AbstractBackgroundRegional control for advanced nodal disease has been only marginally affected by concurrent chemoradiation, hyperfractionation, concomitant boost, or accelerated external radiation.MethodsTwenty‐five necks in 24 patients received brachytherapy treatment (20 Gy in 10 twice‐daily fractions) in addition to external radiation, neck dissection ± chemotherapy. Indications for brachytherapy included initial treatment of bulky disease (n = 12), recurrence of neck disease in a previously treated patient with at least a 3‐month disease‐free interval (n = 6), persistent disease after a curative efforts (n = 4), inadequate external radiation (ie, <40 Gy) due to either intolerance or noncompliance (n = 3).ResultsOverall actuarial regional control was 67% at 2 years. Regional control for those receiving brachytherapy as part of their initial treatment was 82% despite a mean nodal diameter of 8.7 cm (range, 5–15 cm). The 2‐year actuarial regional control was 56% for the patients with a disease‐free interval of at least 3 years.ConclusionHigh‐dose‐rate brachytherapy produced excellent regional control. © 2008 Wiley Periodicals, Inc. Head Neck, 2008
Lymphadenomatous carcinoma of the sublingual gland: Report of a first case in an unusual localization
Authors: Kwon Yong‐Dae , Biesterfeld Stefan , Hansen Torsten , Schwerdtfeger Andreas , Kunkel Martin 
Published: March 2008

AbstractBackground.Lymphadenomatous carcinoma of the salivary gland is a very rare tumor, which hitherto occurred exclusively in the parotid gland. This report describes a case of lymphadenomatous carcinoma of the sublingual gland, which is thought to be the first report of this special entity.Methods and Results.A 36‐year‐old man was seen with slowly growing mass on his right floor of mouth. Upon surgical removal, the mass was well encapsulated. Microscopic examination revealed a biphasic appearance with islands of neoplastic epithelial cells presenting against a dense lymphoid stroma, while the epithelial compartment showed features of malignancy. During 30‐months of close follow‐up, there has not been any sign of local recurrence or metastasis.Conclusion.The clinical behavior, the age of the patient, and the sublingual localization differentiate this lesion from the sebaceous type, favoring lymphadenomatous carcinoma as a distinct clinical entity. © 2008 Wiley Periodicals, Inc. Head Neck, 2008
Free tissue transfer reconstruction of the head and neck at a Veterans Affairs hospital
Authors: Myers Larry L. , Sumer Baran D. , Defatta Robert J. , Minhajuddin Abu 
Published: March 2008

AbstractBackgroundThe Veterans Affairs (VA) population is considered to have generally poorer health than its non‐VA counterpart.MethodsWe reviewed our experience with 55 consecutive patients undergoing free tissue transfers for head and neck reconstruction at the Dallas VA Hospital between July 2000 and September 2006, with 6 months' follow‐up.ResultsThe overall success rate was 93% (51 of 55 flaps). Factors affecting flap survival were fasciocutaneous flap versus others (p = .01) and minimal versus excessive intraoperative crystalloid administration (p = .03). Nine different flaps were used. Major and minor complications occurred in 33% (n = 18) and 31% (n = 17) patients, respectively. Average intensive care unit and hospital stays were 7.4 and 16.0 days, respectively.ConclusionsFree flaps for head and neck reconstructions in the VA population can be performed with excellent success rates. Complication rates and hospital days in this population are similar to those of the non‐VA populations. Flap selection and administration of minimal intraoperative fluids are important. © 2008 Wiley Periodicals, Inc. Head Neck, 2008
In vivo patellar tracking: Clinical motions and patellofemoral indices
Authors: Nha Kyung W. , Papannagari Ramprasad , Gill Thomas J. , Van de Velde Samuel K. , Freiberg Andrew A. , Rubash Harry E. , Li Guoan 
Published: March 2008

AbstractPatellar tracking during in vivo weightbearing knee function is not well understood. This study investigated patellar tracking of eight subjects during a full range of weightbearing flexion using magnetic resonance imaging and dual orthogonal fluoroscopy. The data were reported using a clinical description based on patellar and femoral joint coordinate systems and using patellar indices based on geometrical features of the femur and patella. The mean patellar shift was within 3 mm over the entire range of flexion. The patella tilted laterally from 0° to 75°, and then tilted medially beyond 75° of flexion. The mean tilt was within 6°. Similarly, the mean patellar rotation was small at early flexion, and the mean total excursion of patellar rotation was about 8°. The patellofemoral indices showed that the mean sulcus angle and congruence angle varied within 8° over the entire flexion range. The mean lateral patellar displacement was within 6 mm. A consistent decrease in lateral patellar tilt and an increase in lateral patellofemoral angle were observed with knee flexion. In conclusion, patellar motion is relatively small with respect to the femur during in vivo weightbearing knee flexion. These data may provide baseline knowledge for understanding normal patellar tracking. © 2008 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 26:1067–1074, 2008
Knee joint biomechanics following arthroscopic partial meniscectomy
Authors: Sturnieks Daina L. , Besier Thor F. , Mills Peter M. , Ackland Tim R. , Maguire Ken F. , Stachowiak Gwidon W. , Podsiadlo Pawel , Lloyd David G. 
Published: March 2008

AbstractWe investigated spatiotemporal data, joint kinematics, and joint kinetics during gait in a group of subjects who had recently undergone arthroscopic partial meniscectomy and compared the results to those of healthy controls. Gait analysis was performed on 105 pain‐free meniscectomy patients and 47 controls, walking at a self‐selected speed. The meniscectomy population was comparable to controls in spatiotemporal parameters and knee kinematics. However, they had reduced range of motion (ROM) and lower peak moments in the sagittal plane on the operated limb compared to the nonoperated limb. Compared to controls, the meniscectomy patients had significantly larger knee adduction moments over stance, even after accounting for their greater body weight. These differences likely increase articular loads on the medial compartment of the tibiofemoral joint and may contribute to the high risk of knee osteoarthritis following arthroscopic meniscal surgery. © 2008 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 26:1075–1080, 2008
Effects of a bioscaffold on collagen fibrillogenesis in healing medial collateral ligament in rabbits
Authors: Liang Rui , Woo Savio L‐Y. , Nguyen Tan D. , Liu Ping‐Cheng , Almarza Alejandro 
Published: March 2008

AbstractBioscaffolds have been successfully used to improve the healing of ligaments and tendons. In a rabbit model, the application of porcine small intestine submucosa (SIS) to the healing medial collateral ligament (MCL) resulted in improved mechanical properties with the formation of larger collagen fibrils. Thus, the objective of the study was to find out whether the SIS bioscaffold could improve the gene expressions of fibrillogenesis‐related molecules, specifically, collagen types I, III, V, and small leucine‐rich proteoglycans including decorin, biglycan, lumican, and fibromodulin, as well as collagen fibril morphology and organization, in the healing rabbit MCL at an early time point (6 weeks postinjury). Twenty skeletally mature rabbits were equally divided into two groups. In the SIS‐treated group, a 6‐mm gap was surgically created and a layer of SIS was sutured to cover the gap, whereas the gap was left open in the nontreated group. At 6 weeks postinjury, Masson's trichrome staining showed that the SIS‐treated group had more regularly aligned collagen fibers and cells. Transmission electron microscopy revealed that the SIS‐treated group had larger collagen fibrils with a diameter distribution from 24 to 120 nm, whereas the nontreated group had only small collagen fibrils (ranging from 26 to 87 nm, p < 0.05). Finally, the quantitative real‐time PCR showed that the mRNAs of collagen type V, decorin, biglycan, and lumican in the SIS‐treated group were 41, 58, 51, and 43% lower than those in the nontreated group, respectively (p < 0.05). Such significant reduction in the gene expressions are closely related to the improved morphological characteristics, which are known to be coupled with better mechanical properties, as previously reported in longer term studies. © 2008 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 26:1098–1104, 2008
Variation of cyclic strain parameters regulates development of elastic modulus in fibroblast/substrate constructs
Authors: Joshi Sagar D. , Webb Ken 
Published: March 2008

AbstractDynamic mechanical culture systems are a widely studied approach for improving the functional mechanical properties of tissue engineering constructs intended for loading‐bearing orthopedic applications such as tendon/ligament reconstruction. The design of effective mechanical stimulation regimes requires a fundamental understanding of the effects of cyclic strain parameters on the resulting construct properties. Toward this end, these studies employed a modular cyclic strain bioreactor system and fibroblast‐seeded, porous polyurethane substrates to systematically investigate the effect of varying cyclic strain amplitude, rate, frequency, and daily cycle number on construct mechanical properties. Significant differences were observed in response to variation of all four loading parameters tested. In general, the highest values of elastic modulus within each experimental group were observed at low to intermediate values of the experimental variables tested, corresponding to the low to subphysiological range (2.5% strain amplitude, 25%/s strain rate, 0.1–0.5 Hz frequency, and 7,200–28,800 cycles/day). These studies demonstrate that fibroblasts are sensitive and responsive to multiple characteristics of their mechanical environment, and suggest that systematic optimization of dynamic culture conditions may be useful for the acceleration of construct maturation and mechanical function. © 2008 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 26:1105–1113, 2008
The stationary set splitting game
Authors: Larson Paul B. , Shelah Saharon 
Published: March 2008

AbstractThe stationary set splitting game is a game of perfect information of length ω1 between two players, unsplit and split, in which unsplit chooses stationarily many countable ordinals and split tries to continuously divide them into two stationary pieces. We show that it is possible in ZFC to force a winning strategy for either player, or for neither. This gives a new counterexample to Σ22 maximality with a predicate for the nonstationary ideal on ω1, and an example of a consistently undetermined game of length ω1 with payoff de.nable in the second‐order monadic logic of order. We also show that the determinacy of the game is consistent with Martin's Axiom but not Martin's Maximum. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
The potential of sphingomyelin as a chemopreventive agent in AOM‐induced colon cancer model: wild‐type and p53+/– mice
Authors: Hu Ying , Le Leu Richard K. , Belobrajdic Damien , Young Graeme P. 
Published: March 2008

AbstractA protective effect of sphingolipids on colorectal cancer (CRC) has been reported in certain mouse strains. It is unknown if sphingolipids are protective in a p53 deficiency mouse model of CRC. This study investigated the effect of sphingomyelin (SM) on intestinal sphingomyelinase (SMase) activity, colonic epithelial biology and azoxymethane (AOM)‐induced CRC. Groups of wild‐type (C57BL/6J) and p53+/– mice were fed 0.1% SM diet for 4 wk, administered a single AOM injection and then killed 6 h later to measure apoptosis and proliferation. Separately, both mouse types were fed 0.05% SM diet, administered three AOM injections and killed 33–38 wk later to measure tumour formation. SM significantly increased SMase activity and reduced proliferation (p < 0.05) in wild‐type and p53+/– mice. SM did not regulate baseline apoptosis, apoptotic response to AOM or apoptosis in tumours, nor did it restore defective apoptosis in p53+/– mice. There was a nonsignificant trend to reduced tumour incidence with SM in wild‐type (p = 0.15) and p53+/– (p = 0.12) mice. In conclusion, while increasing intestinal SMase activity and suppressing proliferation, SM did not promote any form of apoptosis and failed to achieve significant protection in these mice. Further investigation to understand the variable effect of SM in preventing CRC is warranted.
NMR study of the gelation of a designed gelator
Authors: Brand Torsten , Nolis Pau , Richter Sven , Berger Stefan 
Published: March 2008

AbstractThe gelation of a designed gelator was investigated by different NMR methods, which showed a clear thermal hysteresis. Two very simple approaches for the NMR determination of the gelation point are suggested. One involves the observation of the NMR integral, and the other records the ratio of the diffusion coefficients between the gelator and the solvent. Differential behavior of the gelator protons are interpreted as a hint that a part of the gelator molecule might still be flexible as in the dissolved state. Copyright © 2008 John Wiley & Sons, Ltd.
Error correction and convex programming
Authors: Candès Emmanuel , Randall Paige 
Published: March 2008

AbstractThis article discusses a recently proposed error correction method involving convex optimization [1]. From an encoded and corrupted real‐valued message, a receiver would like to determine the original message. A few entries of the encoded message are corrupted arbitrarily (which we call gross errors) and all the entries of the encoded message are corrupted slightly. We show that it is possible to recover the message with nearly the same accuracy as in the setting where no gross errors occur. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Experiments on the transition to three‐dimensional flow structures in two‐sided lid‐driven cavities
Authors: Siegmann‐Hegerfeld T. , Albensoeder S. , Kuhlmann H. C. 
Published: March 2008

AbstractFlow instabilities in two‐sided lid‐driven cavities are studied experimentally. The transition of the nearly two‐dimensional flow to steady or time‐dependent three‐dimensional flow structures is investigated for one‐sided, for parallel, and for antiparallel motion of the driving walls and for two aspect ratios, Γ = 0.76 and Γ = 1. Stability diagrams are obtained by flow visualization. Six different three‐dimensional flow patterns have been characterized, each corresponding to a particular critical mode of a linear‐stability analysis. The structures of the near‐critical flows and the critical curves are in good agreement with the corresponding numerical predictions. In a few cases, however, the critical Reynolds numbers deviate form the numerical results. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Numerical modelling of shear‐thinning non‐Newtonian flow in compliant vessels
Authors: Zaušková Anna , Lukáčová‐Medvid'ová Mária 
Published: March 2008

AbstractWe present recent results on numerical modelling of non‐Newtonian flow in two‐dimensional compliant vessels with application in hemodynamics. Two models of the shear‐thinning non‐Newtonian fluids are considered and compared with the Newtonian model. For the structure problem the generalized string equation for radial symmetric tubes is used and extended to a stenosed vessel. A global iterative approach is used to approximate the fluid‐structure interaction. At the end we present numerical experiments for selected non‐Newtonian models, comparisons with the Newtonian model and the hemodynamic wall parameters: the wall shear stress and the oscillatory stress index. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
On the dynamics of a nonlinear rotor‐floating ring bearing system
Authors: Boyaci Aydin , Seemann Wolfgang , Proppe Carsten 
Published: March 2008

AbstractToday, in high speed applications the rotors are commonly supported by hydrodynamic journal bearings. One typical configuration of journal bearings incorporated in automotive turbochargers is the floating ring bearing. Rotors supported by floating ring bearings have many advantages, regarding costs and power consumption for example. However, they might become unstable with increasing speed of rotation. At the onset of instability both the perfectly balanced and unbalanced rotor undergo self‐excited vibrations which could cause the mechanical breakdown of the system. The “oil whip”‐phenomenon, very well known from the investigations of the plain journal bearing occurs here in a different form. At the stability limit the rotor begins either oscillating with about the half of the ring speed or the half of the ring speed plus the half of the journal speed depending on the system parameters.For this reason a rotor‐floating ring bearing model is presented showing the mentioned characteristics. By applying the nonlinear equations of motion the limit cycles of the system are determined and its loss of stability is investigated. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Eigenanalysis of multi‐walled carbon nanotubes by using the impulse response
Authors: Claeyssen Julio R. , Tsukazan Teresa , Copetti Rosemaira D. , Vielmo Sandra 
Published: March 2008

AbstractThe van der Waals interaction elastic force is included in the modeling of multi‐walled carbon nanotubes (MWNT) as an Euler‐Bernoulli elastic system. The coupled eigenvalue problem is formulated in terms of a basis generated by a fundamental matrix response. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Change point oriented multiscale analysis using the lifting scheme
Authors: Jansen Maarten 
Published: March 2008

AbstractWe discuss a non‐linear, change point driven multiscale decomposition, known as normal offsets or normal meshes (in 2‐D). Unlike a wavelet transform, the proposed decomposition runs from coarse to fine scales. The coarse‐to‐fine approach can be seen as an adaptive sampler with theoretical and practical benefits in compression. It is, however, also a source of potential stability problems. Stability is crucial in applications as de‐noising, or simultaneous de‐noising and compression. As the normal offset transform is based on the lifting scheme, we investigate lifting steps that both contribute to stability and allow usage in a change point adaptive normal offset scheme. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Discussion on appropriate material parameters for a porous media model of the IVD
Authors: Karajan Nils , Ehlers Wolfgang 
Published: March 2008

AbstractThe determination of the theoretically introduced material parameters is always a big issue, especially in computational biomechanics. In this context it is difficult to obtain the appropriate intervertebral disc (IVD) specimens within 24 h post decease and to perform reliable experiments on them, respectively. A complex test setup is needed for most of the cases and the measured results are very ‘patient specific’. On the other hand, the parameters obtained from literature are often also not reliable, because they are widespread, the experimental setup is not clearly described or was deficient. Moreover, as soft tissues generally exhibit a coupled dissipative behaviour, it is often not possible to measure these effects independently. Hence, the parameters have to be identified by inverse computations, i. e., axial compression, bending or torsion of a whole motion segment. The goal of this contribution is to proceed from an extended biphasic model and a set of suitable material parameters obtained from literature, in order to find the influence of certain parameters on a numerical compression‐bending experiment of a L4‐L5 motion segment. Finally, a comment on how the respective parameters should be determined is given. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)