bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lower Osteopontin Plasma Levels Are Associated With Superior Outcomes in Advanced Non–Small-Cell Lung Cancer Patients Receiving Platinum-Based Chemotherapy: SWOG Study S0003
Authors: Mack Philip C. , Redman Mary W. , Chansky Kari , Williamson Stephen K. , Farneth Nichole C. , Lara Primo N. , Franklin Wilbur A. , Le Quynh-Thu , Crowley John J. , Gandara David R. 
Published: September 2008

Purpose S0003 was a phase III trial of carboplatin/paclitaxel with or without the hypoxic cytotoxin tirapazamine in patients with advanced or metastatic non–small-cell lung cancer (NSCLC). We investigated the relationship between clinical outcomes and plasma levels of the hypoxia-associated protein osteopontin (OPN) in patients on this protocol. Patients and Methods Baseline plasma was obtained from 172 patients. In 56 patients, sequential plasma was obtained after one or two cycles. Concentrations of OPN, as well as plasminogen activator inhibitor-1 (PAI-1) and vascular endothelial growth factor (VEGF), were measured using enzyme-linked immunosorbent assay. Tumor expression of OPN was assessed by immunohistochemistry in 61 matched archival specimens. Results Patients with lower OPN levels (below the median) had a significantly superior overall survival compared with patients with higher levels, regardless of treatment arm (hazard ratio [HR] = 0.60, P = .002). A similar correlation was observed for progression-free survival (HR = 0.69, P = .02). When examined as a continuous variable, OPN maintained its significant association with both progression-free (HR = 1.05, P = .01) and overall survival (HR = 1.09, P < .0001). Patients with lower plasma OPN levels were significantly more likely to have tumor response (P = .03). No differences were observed between treatment arms. Tumor OPN levels did not correlate with patient outcomes or with plasma levels. No associations were observed between patient outcomes and VEGF or PAI-1 levels; however, plasma concentrations of these markers were significantly interrelated (P < .0001) and significantly decreased after treatment (P = .0002 and P = .03, respectively). Conclusion Pretreatment plasma levels of OPN are significantly associated with patient response, progression-free survival, and overall survival in chemotherapy-treated patients with advanced NSCLC.
Contact resistance study of high-copper alloys used in power automotive connectors
Authors: El Abdi R , Beloufa A , Benjemaâ N 
Published: September 2008

Contact resistance of the copper alloys used in automotive connectors was studied in the literature, but no study has been undertaken in order to optimize this resistance for the new high-copper alloys intended for power automotive connectors. This study was carried out in order to determine the changes in resistance for different loadings and contact geometries. A new generation of high-performance copper alloys was analysed. The used samples were U shaped with a segment containing a sphere and were subjected to insertion (sliding contact) and indentation (static contact) tests. A finite element simulation using the ANSYS code gave contact modellings with or without roughness; this roughness was measured with a profilometer. Numerical modelling of the contact surfaces when the roughness of the materials was taken into account led to results close to the experimental results especially in the case of the lower forces during the indentation test. On the other hand, a relation between the contact resistance and the contact force was established. These results could help in the choice of a material to provide a good compromise concerning both the electrical and the mechanical aspects for a power connector used for automotive industry.
Strict Glycemic Targets Need Not Be So Strict: A More Permissive Glycemic Range for Critically Ill Children
Authors: Ulate Kalia Patricia , Lima Falcao Germano Correia , Bielefeld Mark Richard , Morales John Mark , Rotta Alexandre Tellechea 
Published: September 2008

OBJECTIVE. The goal was to determine whether a more permissive glycemic target would be associated with a decreased incidence of hypoglycemia but not increased mortality rates in critically ill pediatric patients.
METHODS. This retrospective study evaluated clinical and laboratory data for 177 patients who underwent 211 consecutive surgical procedures for repair or palliation of congenital heart defects at Driscoll Children's Hospital. To establish the relationship between postoperative glycemia and subsequent morbidity and mortality rates, patients were stratified into 4 groups according to their median glucose levels, that is, euglycemia (60–125 mg/dL, 3.3–6.9 mmol/L), mild hyperglycemia (126–139 mg/dL, 6.9–7.7 mmol/L), moderate hyperglycemia (140–179 mg/dL, 7.7–9.9 mmol/L), or severe hyperglycemia (≥180 mg/dL, ≥9.9 mmol/L). Postoperative outcomes for those groups also were compared with outcomes for a more permissive glycemic target group (90–140 mg/dL, 5–7.7 mmol/L).
RESULTS. The peak and mean blood glucose measurements and duration of hyperglycemia were not different for survivors and nonsurvivors in the first 24 hours after surgery. Nonsurvivors had higher peak glucose levels (389.3 ± 162 mg/dL vs 274.4 ± 106.3 mg/dL, 21.4 ± 8.9 mmol/L vs 15.1 ± 5.9 mmol/L) and longer duration of hyperglycemia (3.06 ± 1.67 days vs 2.11 ± 0.92 days) during the first 5 postoperative days, compared with survivors. Mortality rates were significantly higher for the moderate (38.8%) and severe (58.3%) hyperglycemia groups, compared with the euglycemia (6.02%) and permissive target (4.69%) groups. The incidence of hypoglycemia was significantly higher in the euglycemia group (31.8%), compared with the permissive target group (17.18%).
CONCLUSIONS. Postoperative hyperglycemia is associated with increased morbidity and mortality rates in children after surgical repair of congenital heart defects. A more permissive glycemic target is associated with a lower incidence of hypoglycemia but not increased mortality rates in these patients.
Textual Encounters of Three Kinds: Engaging in Reading Through Community Astronomy Night
Authors: Johnson Amy Suzanne , Rezak Achariya Tanya , Hodges Georgia , Lawrence Molly , Tippins Deborah , Bongkotphet Thitiya 
Published: September 2008

This article describes a community science night as a professional development experience for teachers in a rural school in the southeastern United States. As participants circulated through eight astronomy activities, they engaged in reading images, reading writing, and reading their natural and physical world. Through such diverse textual encounters, participants were given multiple means for accessing science, and teachers were given a model for understanding the relationship between science and literacy.تصف هذه المقالة ليلة مجتمع علمية كتجربة التنمية المهنية للأساتذة في مدرسة ريفية في جنوب شرق الولايات المتّحدة. حين تجوّل المشتركون في ثماني أنشطة علم الفلك انشغلوا في قراءة الصور وقراءة الكتابة وقراءة عالمهم الطبيعي والمادّي. وقد توفّرت للمشتركين طرق عديدة لتقييم العلم من خلال تجارب ملموسة متنوّعة وتوفّر للأساتذة نموذج لفهم العلاقة بين العلم ومعرفة القراءة والكتابة.本文描述一间位于美国东南部的农村学校，为教师举办社区科学之夜以作为他们专业培训的经验。当教师巡回参与八项天文学活动时，他们都专注于阅读图像、阅读文字、阅读他们的自然与物理世界。透过这么多样化的篇章接触，参加者认识到多种进入科学知识领域的方法，而教师亦认识到一个用以了解科学与读写能力之间关系的教学模式。Cet article décrit une séance de nuit d'une communauté scientifique en tant qu'expérience de développement professionnel d'enseignants d'une école rurale du sud‐est des Etats‐Unis. Alors que les participants passaient par huit activités d'astronomie, ils ont été amenés à lire des images, à lire et à écrire, et à lire le monde physique et la nature autour d'eux. Ainsi, au travers de ces diverses rencontres, les participants ont bénéficié d'une multiplicité de moyens d'accès à la science, et les enseignants ont profité d'un modèle permettant de comprendre les relations entre la science et le monde de l'écrit.В статье описан праздник естественных наук, организованный для местного сообщества в сельской школе на юго‐востоке США, в результате которого учителя этой школы сделали колоссальный шаг вперед в своем профессиональном развитии. Для гостей было подготовлено восемь различных заданий по астрономии: они учились читать изображения, письменный текст, а также явления окружающей природы и мира. Встречи со столь разнообразными видами текста дали гостям множество стимулов и способов заинтересоваться наукой, а учителя познакомились с оптимальной моделью взаимоотношений науки с разными видами грамотности.Este artículo describe una actividad científica comunitaria que tomó lugar una noche como una experiencia de desarrollo profesional para los maestros de una escuela rural del sureste de los Estados Unidos. A medida que los participantes circulaban por ocho actividades sobre la astronomía, ellos participaron en la lectura de imágenes, la lectura de escritos, y la lectura de su mundo natural y físico. Por medio de tales encuentros con textos diversos, se les dio a los participantes múltiples medios para acceder a las ciencias, y se les dio un modelo para entender la relación entre las ciencias y la capacitación.
Evolving Strategies for the Management of Hand–Foot Skin Reaction Associated with the Multitargeted Kinase Inhibitors Sorafenib and Sunitinib
Authors: Lacouture Mario E. , Wu Shenhong , Robert Caroline , Atkins Michael B. , Kong Heidi H. , Guitart Joan , Garbe Claus , Hauschild Axel , Puzanov Igor , Alexandrescu Doru T. , Anderson Roger T. , Wood Laura , Dutcher Janice P. 
Published: September 2008

AbstractThe multitargeted kinase inhibitors (MKIs) sorafenib and sunitinib have shown benefit in patients with renal cell carcinoma, hepatocellular carcinoma (sorafenib), and gastrointestinal stromal tumor (sunitinib). Their efficacy in other malignancies is currently being investigated because of their broad range of activity. The effectiveness of these drugs is somewhat diminished by the development of a variety of toxicities, most notably hand–foot skin reaction (HFSR). Although HFSR does not appear to directly affect survival, it can impact quality of life and lead to MKI dose modification or interruption, potentially limiting the antitumor effect. Currently, no standard guidelines exist for the prevention and management of MKI-associated HFSR. To address this issue, an international, interdisciplinary panel of experts gathered in January 2008 to discuss and evaluate the best-practice management of these reactions. Based on these proceedings, recommendations for the management of HFSR have been provided to offer patients the best possible quality of life while taking these drugs and to optimize the patient benefit associated with MKI therapy.
Rabies surveillance in the United States during 2007
Authors: Blanton Jesse D. , Palmer Dustyn , Christian Kira A. , Rupprecht Charles E. 
Published: September 2008

Abstract
During 2007, 49 states and Puerto Rico reported 7,258 cases of rabies in animals and 1 case in a human to the CDC, representing a 4.6% increase from the 6,940 cases in animals and 3 cases in humans reported in 2006. Approximately 93% of the cases were in wildlife, and 7% were in domestic animals. Relative contributions by the major animal groups were as follows: 2,659 raccoons (36.6%), 1,973 bats (27.2%), 1,478 skunks (20.4%), 489 foxes (6.7%), 274 cats (3.8%), 93 dogs (1.3%), and 57 cattle (0.8%). Compared with numbers of reported cases in 2006, cases in 2007 increased among dogs, bats, foxes, and skunks while decreases were reported among cattle, cats, and skunks. Increases in numbers of rabid raccoons during 2007 were reported by 11 of the 20 eastern states where raccoon rabies was enzootic, and reported cases increased by 1.7% overall, compared with 2006.
On a national level, the number of rabies cases in skunks during 2007 decreased by 1.1% from the number reported in 2006. Texas reported the greatest number (n = 362) of rabid skunks and the greatest overall state total of animal rabies cases (969). No cases of rabies associated with the dog/coyote rabies virus variant were reported. The United States remains free of dog-to-dog transmission of canine rabies virus variants. The total number of cases of rabies reported nationally in foxes increased 14.5%, compared with 2006. Increases in the number of reported rabid foxes were attributable to greater numbers of foxes reported with the Arctic fox rabies virus variant in Alaska, the Texas gray fox rabies virus variant in Texas, and the raccoon rabies virus variant in Virginia. The 1,973 cases of rabies reported in bats represented a 16.6% increase over numbers reported in 2006. Cases of rabies in dogs and in sheep and goats increased 17.7% and 18.2%, respectively, whereas cases reported in cattle, cats, and horses and mules decreased 30.5%, 13.8%, and 20.8%, respectively. In Puerto Rico, reported cases of rabies in mongooses decreased 51.5%, and rabies in domestic animals, presumably attributable to spillover infection from mongooses, increased 25%.
One human rabies case was reported from Minnesota during 2007. Although typing of the rabies virus variant in this case was not possible, an investigation of this case indicated a bat as the most likely source of exposure.
Breed distribution of the ABCB1-1Δ (multidrug sensitivity) polymorphism among dogs undergoing ABCB1 genotyping
Authors: Mealey Katrina L. , Meurs Kathryn M. 
Published: September 2008

Abstract
Objective—To evaluate the breed distribution of the ABCB1-1Δ polymorphism in a large number of dogs in North America, including dogs of several herding breeds in which this polymorphism has been detected and other breeds in which this polymorphism has not yet been identified.
Design—Cross-sectional study.
Animals—5,368 dogs from which buccal swab samples were collected for purposes of ABCB1 genotyping.
Procedures—From May 1, 2004, to September 30, 2007, DNA specimens derived from buccal swab samples collected from 5,368 dogs underwent ABCB1 genotyping. These data were reviewed, and results for each dog were recorded in a spreadsheet, along with the dog's breed. The genotypes for each breed were tallied by use of a sorting function.
Results—The ABCB1-1Δ allele was identified in 9 breeds of dogs and in many mixed-breed dogs. Breeds that had the ABCB1-1Δ allele included Collie, Longhaired Whippet, Australian Shepherd (standard and miniature), Shetland Sheepdog, Old English Sheepdog, Border Collie, Silken Windhound, and German Shepherd Dog (a breed in which this mutation had not been detected previously).
Conclusions and Clinical Relevance—The ABCB1-1Δ polymorphism is associated with increased susceptibility to many adverse drug reactions and with suppression of the hypothalamic-pituitary-adrenal axis and is present in many herding breeds of dog. Veterinarians should be familiar with the breeds that have the ABCB1-1Δ polymorphism to make appropriate pharmacologic choices for these patients.
Evaluation of a questionnaire for obtaining owner-perceived, weighted quality-of-life assessments for dogs with spinal cord injuries
Authors: Budke Christine M. , Levine Jonathan M. , Kerwin Sharon C. , Levine Gwendolyn J. , Hettlich Bianca F. , Slater Margaret R. 
Published: September 2008

Abstract
Objective—To evaluate a questionnaire for obtaining owner-perceived, weighted quality-oflife assessments for dogs with spinal cord injuries.
Design—Evaluation study.
Animals—100 dogs with spinal cord injuries and 48 healthy control dogs.
Procedures—The questionnaire was adapted from a questionnaire (the schedule for the evaluation of individual quality of life–direct weighting) used for human patients. Specifically, owners were asked to identify 5 areas or activities they believed had the most influence on their dogs' quality of life, assess their dogs' current status in each of those areas, and provide a weighting for the importance of each area. Results were used to construct a weighted quality-of-life score ranging from 0 to 100 for each dog. Owners were also asked to provide a quality-of-life score with a visual analog scale (VAS).
Results—A good correlation was found between weighted and VAS quality-of-life scores. Dogs with spinal cord injuries had weighted quality-of-life scores that were significantly lower than scores for control dogs. Quality-of-life areas and activities provided by owners of dogs with spinal cord injuries were similar to areas and activities provided by owners of healthy control dogs and could mostly be encompassed by 5 broader domains: mobility, play or mental stimulation, health, companionship, and other.
Conclusions and Clinical Relevance—Results suggested that the questionnaire could be used to obtain owner-perceived, weighted quality-of-life assessments for dogs with spinal cord injuries. Obtaining owner-perceived quality-of-life assessments for individual dogs should allow veterinarians to better address quality-of-life concerns and expectations of owners.
Some results on multi-valued weakly jungck mappings in b-metric space
Authors: Olatinwo Memudu 
Published: September 2008

Abstract
In this paper, the concept of multi-valued weak contraction of Berinde and Berinde [8] for the Picard iteration in a complete metric space is extended to the case of multi-valued weak contraction for the Jungck iteration in a complete b-metric space. While our main results generalize the recent results of Berinde and Berinde [8], they also extend, improve and unify several classical results pertainning to single and multi-valued contractive mappings in the fixed point theory. Our results also improve the recent results of Daffer and Kaneko [16].
Variability of fluvial transport of the upper Wieprz river
Authors: Stępniewska Sylwia , Stępniewski Krzysztof 
Published: September 2008

Variability of fluvial transport of the upper Wieprz river
This paper shows variability of fluvial transport of the Wieprz river. The catchment of the upper Wieprz river to profile at Guciów located in Central Roztocze Region. In Wieprz during the hydrological years 1996-2006 average annual flow is 1.32 m3·s-1, which correspond to the outflow - 41.5 Mm3·a-1. Extreme values of the flows varied from 0.5 m3·s-1 to 13,1 m3·s-1. Outflow the Wieprz river has feature for the snow-rainy hydrological regime. During the study the annual average suspended load amounted 737 Mg. The annual average dissolved load amounted 10 343 Mg. The bed load estimated for less than 10% of the dissolved load and 1% of the suspended load. The monthly average suspended load and dissolved load were least in the November and were highest in the April. During the period of researches, the average mechanical denudation rates 2.4 Mg·km-2·a-1. Chemical denudation rates were much higher - 36.1 Mg·km-2·a-1. Their differentiation are similar in other regions of Poland.
Simplified technique for the determination of soil aggregation in assessing the resistance of soils to erosion and deflation
Authors: Grigoriev Viktor , Piechnik Leszek , Podsiadłowski Stanisław 
Published: September 2008

Simplified technique for the determination of soil aggregation in assessing the resistance of soils to erosion and deflation
The technique provides for the determination of the size and percentage of aggregates of the coarse fraction on the surface of a friable soil followed by the determination of the aggregation index to be used in assessing spatial and temporal resistance of soil to erosion and deflation. The uses of this technique make routine sampling and aggregate analysis after Savvinov unnecessary. Its some outcomes for soils of Poland are given.
Flow through a helical pipe with rectangular cross-section
Authors: Alam Md Mahmud , Begum Delowara , Yamamoto K 
Published: September 2008

The effects of torsion, aspect ratio and curvature on the flow in a helical pipe of rectangular cross- section are studied by introducing a non-orthogonal helical coordinate system. Spectral method is applied as main tool for numerical approach where Chebyshev polynomial is used. The numerical calculations are obtained by the iterative method. The calculations are carried out for 0â¤ Î´ â¤0.02, 1â¤ Î» â¤ 2.85, 1â¤ Î³ â¤2.4, at Dn = 50 & 100 respectively, where d is the non-dimensional curvature, l the torsion parameter, g the aspect ratio andÂ Dn the pressure driven parameter (Dean number).DOI: http://dx.doi.org/10.3329/jname.v4i2.991Â Journal of Naval Architecture and Marine Engineering Vol.4(2) 2007 p.99-110
Micropropagation of <i>Vanasushava pedata</i> - An Endangered Medicinal Plant of South India
Authors: Karuppusamy S , Kiranmai C , Aruna V , Pullaiah T 
Published: September 2008

An efficient in vitro propagation of an endangered medicinal plant Vanasushava pedata (Apiaceae) by axillary shoot proliferation from nodal segments of mature plants was designed. The medium type and growth regulators markedly influenced in vitro regeneration of V. pedata. An in vitro plantlet production system has been investigated on MS with the synergistic combination of BA (5.0 mg/l), IAA (0.1 mg/l) and 3 % sucrose which promoted the maximum number of shoots (8.6) as well as enhanced shoot lengths. Subculturing of nodal segments from in vitro derived shoots on a similar medium enabled continuous production of healthy shoots with a similar frequency. Rooting was highest (100%) on half strength MS containing IAA (2.0 mg/l). Micropropagated plants established in garden soil and forest humus (1 : 1) were uniform and identical to the donor plants with respect of growth characteristics as well as floral features. These in vitro-raised plants grew normally in greenhouse and natural habitat without showing any morphological variation. Â Key words: Vanasushava pedata, Medicinal plant, Nodal explants, Micropropagation, Successful acclimationDOI = 10.3329/ptcb.v16i2.1109Plant Tissue Cult. & Biotech. 16(2): 85-94, 2006 (December)
Expressed Sequence Tags (ESTs) from a Jute (<i>Corchorus olitorius</i>) cDNA Library
Authors: Taliaferro J Matthew , Islam Ahmad S , Sathasivan Kanagasabapathi 
Published: September 2008

Analysis of the genome of jute (Corchorus olitorius) was done by creating a new cDNA library of expressed sequence tags (ESTs) in pBluescript as the previous libraries reported earlier in this journal yielded only small DNA fragments from chloroplast and mitochondrial DNA. This report discusses results from a cDNA library constructed using poly A+ mRNA purified from 7-day old etiolated jute seedlings. Out of 700 recombinant plasmids obtained, 250 were analyzed using WU-BLAST (www.arabidopsis.org) for similar EST sequences in Arabidopsis thaliana and other higher plants. So far the analysis of the library has yielded several significant sequences, including the complete open reading frame of the 60S acidic ribosomal protein P3 and a partial cDNA of Class I chitinase. These results and future EST sequences from this library will be made available in Genbank and the sequence information will be used to clone full length DNA through PCR. Â DOI = 10.3329/ptcb.v16i2.1110Plant Tissue Cult. & Biotech. 16(2): 95-104, 2006 (December)