bluuebunny/crossref_metadata_2025_split huggingface dataset:
Submaximal clones over a three-element set up to minor-equivalence
Authors: Vucaj Albert , Zhuk Dmitriy 
Published: March 2024

AbstractWe study clones modulo minor homomorphisms, which are mappings from one clone to another preserving arities of operations and respecting permutation and identification of variables. Minor-equivalent clones satisfy the same sets of identities of the form$$f(x_1,\dots ,x_n)\approx g(y_1,\dots ,y_m)$$f(x1,⋯,xn)≈g(y1,⋯,ym), also known as minor identities, and therefore share many algebraic properties. Moreover, it was proved that the complexity of the$${\text {CSP}}$$CSPof a finite structure$$\mathbb {A}$$Aonly depends on the set of minor identities satisfied by the polymorphism clone of$$\mathbb {A}$$A. In this article we consider the poset that arises by considering all clones over a three-element set with the following order: we write$$\mathcal {C}\ {\preceq _{\textrm{m}}}\ \mathcal {D}$$C⪯mDif there exists a minor homomorphism from$$\mathcal {C}$$Cto$$\mathcal {D}$$D. We show that the aforementioned poset has only three submaximal elements.
An approximation of populations on a habitat with large carrying capacity
Authors: Bauman Naor , Chigansky Pavel , Klebaner Fima 
Published: March 2024

AbstractWe consider stochastic dynamics of a population which starts from a small colony on a habitat with large but limited carrying capacity. A common heuristics suggests that such population grows initially as a Galton–Watson branching process and then its size follows an almost deterministic path until reaching its maximum, sustainable by the habitat. In this paper we put forward an alternative and, in fact, more accurate approximation which suggests that the population size behaves as a special nonlinear transformation of the Galton–Watson process from the very beginning.
Age- and sex-specific physiological cardiac remodeling: the search for the Fountain of Youth
Authors: Markwirth Philipp , Haring Bernhard 
Published: March 2024

Graphical Abstract
Figure: Concepts of cardiac aging. Abbreviations: E/e’, transmitral early velocity to early diastolic mitral annular velocity; EF, ejection fraction; LV, left ventricular; LVEDD, left ventricular end-diastolic diameter; M/V left, ventricular mass to volume ratio.
A reduced-order computational homogenization framework for locally resonant metamaterial structures
Authors: Russillo Andrea Francesco , Kouznetsova Varvara G. , Failla Giuseppe , Geers Marc G. D. 
Published: March 2024

AbstractA computational homogenization framework is presented to study the dynamics of locally resonant acoustic metamaterial structures. Modelling the resonant units at the microscale as representative volume elements and building on well-established scale transition relations, the framework brings as a main novelty a reduced-order macroscopic homogenized continuum whose governing equations involve no additional variables to describe the microscale dynamics unlike micromorphic homogenized continua obtained by alternative computational homogenization approaches. This model-order reduction is obtained by formulating the governing equations of the micro- and macroscale problems in the frequency domain, introducing a finite-element discretization of the two problems and performing an exact dynamic condensation of all the degrees of freedom at the microscale. An appropriate inverse Fourier transform approach is implemented on the frequency-domain equations to capture transient dynamics as well; notably, the implementation involves the Exponential Window Method, here applied for the first time to calculate the time-domain response of undamped locally resonant acoustic metamaterial structures. The framework may handle arbitrary geometries of micro- and macro-structures, any transient excitations and any boundary conditions on the macroscopic domain.
Longitudinal assessment of classic and 11-oxygenated androgen concentrations and their association with type 2 diabetes mellitus development: the Tromsø study
Authors: Allaoui Giovanni , Rylander Charlotta , Fuskevåg Ole-Martin , Grimnes Guri , Averina Maria , Wilsgaard Tom , Berg Vivian 
Published: March 2024

Abstract
Aim
We aimed to investigate changes in pre-diagnostic concentrations of classic and 11-oxygenated androgens in type 2 diabetes (T2DM) cases and healthy controls, associations between androgen concentrations and T2DM, and the potential for androgens to improve the prediction of T2DM when considered in combination with established risk factors.

Methods
Androgen concentrations were analysed in serum samples from 116 T2DM cases and 138 controls at 3, pre-diagnostic time-points: 1986/87 (T1), 1994/95 (T2), and 2001 (T3). Generalised estimating equations were used to longitudinally examine androgen concentrations, and logistic regression models were used to estimate the odds ratios (OR) of T2DM at each time-point. Logistic regression models were also used to calculate area under the receiver operating characteristics curve (AROC) from models including established risk factors alone (ERF model) and established risk factors plus each androgen, respectively, which were compared to identify improvements in predictive ability.

Results
For women, no significant associations were observed between any of the investigated androgens and T2DM after adjusting for confounders. For men, after adjusting for confounders, concentrations of all investigated 11-oxygenated androgens were higher in cases than controls at one or several time-points. We observed associations between T2DM and concentrations of 11-ketoandrostenedione (OR: 1.59) and 11-ketotestosterone (OR: 1.62) at T1; and 11-hydroxyandrostenedione (OR: 2.00), 11-hydroxytestosterone (OR: 1.76), 11-ketoandrostenedione (OR: 1.84), 11-ketotestosterone (OR: 1.78) and testosterone (OR: 0.45) at T3 in men. The addition of these androgens (including 11-hydroxytestosterone at T2) to the ERF model resulted in an improved ability to predict T2DM in men (AROC: 0.79–0.82). We did not observe significant differences in changes in androgen concentrations over time between cases and controls in either sex.

Conclusion
Our results demonstrate that testosterone and 11-oxygenated androgens are associated with T2DM in men before diagnosis and may be potential biomarkers in T2DM risk assessment.
Positionspapier der Deutschen Arbeitsgemeinschaft Krankenhaus-Einsatzplanung (DAKEP e. V.) zur baulichen Planung von Krankenhausneubauten im Kontext Terrorismus, Amok sowie Bündnis- und Landesverteidigung
Authors: Wurmb T. , Scholtes K. , Kolibay F. , Lechleuthner A. , Scholtes G. , Schwarzmann G. 
Published: March 2024

ZusammenfassungTerrorismus, Amok und in zunehmendem Maße auch die mögliche Notwendigkeit der Bündnis- und Landesverteidigung (BV/LV) stellen für Krankenhäuser in Deutschland eine ernst zu nehmende Herausforderung dar, auf die sie aktuell nicht ausreichend und aus baulichen Aspekten gar nicht vorbereitet sind. Für Krankenhausneubauten gibt es keine verbindlichen Normen, um einen Schutz von Personal und Patienten sowie eine Aufrechterhaltung der medizinischen Versorgung bestmöglich sicherzustellen. Es bleibt den Nutzern und Bauherren überlassen, unter Umständen nach persönlichen Präferenzen entsprechende bauliche Schutzkonzepte zu entwickeln, zu planen und umzusetzen. Deren Finanzierung ist nicht geregelt, was einen erheblich hemmenden Faktor für eine Umsetzung und etwaige Baugenehmigungsverfahren und Haushaltsfreigaben darstellt. Die Arbeitsgemeinschaft Krankenhaus-Einsatzplanung (DAKEP e. V.) sieht in diesen Umständen ein erhebliches Defizit, für das dringend Abhilfe geschaffen werden muss. Ziel dieses Positionspapiers ist es, die Hintergründe zu beleuchten und Vorschläge für ein Minimalset an baulichen Maßnahmen zu definieren, die bei Terror und Amok, aber auch BV/LV die Sicherheit an Krankenhäusern für Patienten und Personal erhöhen und speziell die Aufrechterhaltung der medizinischen Versorgung bei BV/LV möglichst verlängern können.
Aging-associated changes of optical coherence tomography-measured ganglion cell-related retinal layer thickness and visual sensitivity in normal Japanese
Authors: Iwase Aiko , Higashide Tomomi , Fujii Makoto , Ohno Yuko , Tanaka Yuki , Kikawa Tsutomu , Araie Makoto 
Published: March 2024

Abstract
Purpose
To report aging-associated change rates in circumpapillary retinal nerve fiber layer thickness (cpRNFLT) and macular ganglion cell-inner plexiform layer and complex thickness (MGCIPLT, MGCCT) in normal Japanese eyes and to compare the data in linear scaled visual field (VF) sensitivity of central 4 points of Humphrey Field Analyzer (HFA) 24-2 test (VF4TestPoints) to that in MGCIPLT in four 0.6-mm-diameter circles corresponding to the four central points of HFA 24-2 adjusted for retinal ganglion cell displacement (GCIPLT4TestPoints).

Study design
Prospective observational study

Methods
HFA 24-2 tests and spectral-domain optical coherence tomography (SD-OCT) measurements of cpRNFLT, MGCIPLT, MGCCT and GCIPLT4TestPoints were performed every 3 months for 3 years in 73 eyes of 37 healthy Japanese with mean age of 50.4 years. The time changes of SD-OCT-measured parameters and VF4TestPoints were analyzed using a linear mixed model.

Results
The aging-associated change rates were -0.064 μm/year for MGCIPLT and and -0.095 for MGCCT (P=0.020 and 0.017), but could not be detected for cpRNFLT. They accelerated with aging at -0.009μm/year/year of age for MGCIPLT (P<0.001), at 0.011 for MGCCT (P<0.001) and at 0.013 for cpRNFLT(0.031). The aging-associated decline of -82.1 [1/Lambert]/year of VF4TestPoints corresponded to -0.095 μm/year of GCIPLT4TestPoints.

Conclusion
We report that aging-associated change rates of cpRNFLT, MGCIPLT and MGCCT in normal Japanese eyes were found to be significantly accelerated along with aging. Relationship between VF sensitivity decline rates and SD-OCT measured GCIPLT decline rates during physiological aging in the corresponding parafoveal retinal areas are also documented.
Dynamic analysis of resistance in Colombian elite Hevea brasiliensis genotypes as a breeding strategy for enhancing South American leaf blight management under disease non-escape conditions in the Amazon region
Authors: Galindo-Rodríguez Lyda Constanza , Sterling Armando , Muñoz-Ramirez Herminton , Martínez-Moyano Edgar , Fonseca-Restrepo Jesica Andrea , Loaiza-Molina Luis Carlos 
Published: March 2024

AbstractSouth American Leaf Blight (SALB) is the primary limitation to the establishment of new rubber (Hevea brasiliensis) crops in Latin America. This study aimed to assess the temporal dynamics of resistance to SALB in 99 elite Colombian genotypes and the IAN 873 cultivar (control) of H. brasiliensis in small-scale clone trials conducted under conditions with a high disease prevalence in the northwestern Colombian Amazon. Resistance monitoring was carried out on a monthly basis and analyzed over five climatic periods. Three variables were recorded: attack severity (AT, ranging from 0 to 4), reaction type (TR, ranging from 1 to 6) and stromal density (ST, ranging from 0 to 4). The maximum scores for TR and ST were used to classify the level of resistance of the genotypes. Highly significant differences in the mean values of AT, TR and ST among the genotypes, across the periods, and in the interaction between genotype and period were found. Over time, an increase in symptoms (AT) and signs (TR and ST) of SALB was observed. During the rainy periods, SALB intensity was highest, resulting in a leaf area affected ranging from 16 to 30%. Eight genotypes showed partial resistance (PR) (TR < 5 and ST < 2), while 16 genotypes demonstrated complete resistance (CR) (TR < 3 and ST = 0), and 76 genotypes were highly susceptible (HS) (TR > 5 or ST > 2). The temporal analysis identified 23 Colombian superior genotypes with varying degrees of SALB resistance, which can be a valuable breeding resource for improving SALB management in the Colombian Amazon region.
Understanding sustainable growth in the face of economic policy uncertainties
Authors: Tiange Xiang , Mirza Sultan Sikandar , Zhang Chengwei , Huang ChengMing 
Published: March 2024

AbstractThis paper investigates the impact of economic policy uncertainty (EPU) in China, measured by a news-based index, on the sustainable growth of 2771 Chinese non-financial A-share firms (including 1674 SMEs and 1097 non-SMEs) from 2010 to 2022. We also analyze how green business practices moderate the impact of EPU on firms' sustainable growth. After implying various econometric models, this study finds that EPU has a significant negative effect on the sustainable growth of Chinese firms, which is more pronounced among non-SMEs. Heterogeneity analysis reveals that the negative impact of EPU on CSG is more pronounced in big firms, highly leveraged firms, firms with low liquidity and low financialization in China. We further reveal that this negative impact of EPU stems from trade policy uncertainties. Furthermore, findings reveal that green business activities positively moderate the association between EPU and sustainable growth, and that this moderating impact is more pronounced among SMEs. These findings are consistent with various robustness approaches. This paper provides useful insights for enterprises to improve their sustainable growth in the context of economic policy uncertainties by adjusting their number of employees, board of directors, average age of staffs, financialization level and debt flexibility.
Set Valued Equilibrium Problems Without Linear Structure
Authors: Benedetti Irene , Martellotti Anna 
Published: March 2024

AbstractIn this paper we give several existence results for solutions of equilibrium problems in topological spaces without linear structure. To this end we introduce a new concept of convexity for maps and multivalued maps in spaces without linear structure. The discussion on convexity is enriched with some example useful to compare the new conditions with the existing one in literature. Finally, we apply the existence results obtained to a Nash equilibrium problem and to a maximization of a binary relation.
Quantum Join Ordering by Splitting the Search Space of QUBO Problems
Authors: Nayak Nitin , Winker Tobias , Çalıkyılmaz Umut , Groppe Sven , Groppe Jinghua 
Published: March 2024

AbstractThe join order has a huge impact on the execution time of a query, such that finding an optimal join order plays a crucial role in query optimization. However, join order optimization is known to be NP-hard. Hence, in this paper, we propose an approach for accelerating join order optimization by quantum computers. We extend our previous approach supporting bushy join trees by splitting the search space of possible join orders and solving each of these subspaces on currently available quantum computers to optimize the join of more relations than our previous approach. We have integrated our approach to quantum query optimization in the relational database management system PostgreSQL to conduct studies with real-world queries. In our experiments, we show that we can perform join order optimization up to 7 relations for real-world queries using quantum annealing and up to 8 relations for artificial queries using simulated annealing with a reasonable number of QUBO problems solved by D‑Wave’s Quantum Annealer. Furthermore, we show that our approach can be also used to perform join-order for queries joining five relations on circuit-based quantum computers running the quantum approximate optimization algorithm (QAOA) and variational quantum eigensolver (VQE) approaches.
Alterations of DNA methylation profile in peripheral blood of children with simple obesity
Authors: Ren Yi , Huang Peng , Huang Xiaoyan , Zhang Lu , Liu Lingjuan , Xiang Wei , Liu Liqun , He Xiaojie 
Published: March 2024

Abstract
Purpose
To investigate the association between DNA methylation and childhood simple obesity.

Methods
Genome-wide analysis of DNA methylation was conducted on peripheral blood samples from 41 children with simple obesity and 31 normal controls to identify differentially methylated sites (DMS). Subsequently, gene functional analysis of differentially methylated genes (DMGs) was carried out. After screening the characteristic DMGs based on specific conditions, the methylated levels of these DMS were evaluated and verified by pyrosequencing. Receiver operating characteristic (ROC) curve analysis assessed the predictive efficacy of corresponding DMGs. Finally, Pearson correlation analysis revealed the correlation between specific DMS and clinical data.

Results
The overall DNA methylation level in the obesity group was significantly lower than in normal. A total of 241 DMS were identified. Functional pathway analysis revealed that DMGs were primarily involved in lipid metabolism, carbohydrate metabolism, amino acid metabolism, human diseases, among other pathways. The characteristic DMS within the genes Transcription factor A mitochondrial (TFAM) and Piezo type mechanosensitive ion channel component 1(PIEZO1) were recognized as CpG-cg05831083 and CpG-cg14926485, respectively. Furthermore, the methylation level of CpG-cg05831083 significantly correlated with body mass index (BMI) and vitamin D.

Conclusions
Abnormal DNA methylation is closely related to childhood simple obesity. The altered methylation of CpG-cg05831083 and CpG-cg14926485 could potentially serve as biomarkers for childhood simple obesity.
Patent Quality: A Critique of the State of the Discussion
Authors: Liu Li 
Published: March 2024

AbstractDespite decades of research and debate, the narrative that low-quality patents stifle innovation remains fraught with controversy. It is called into question because the term “patent quality” seems to be a potential misnomer, and reforms to improve patent quality are ineffective. The purpose of this study is to offer a comparative critique of the debate regarding patent quality in the European Union and the United States. It investigates five factors relating to the history of this debate, contested definitions, measurements of quality, proposals that are not implemented, and reforms that are implemented. The main contribution of this paper is to review how the debate has been constructed, indicating that certain arguments seem to talk past each other and consensus is hard to reach, that measurements are flawed, and that proposals and reforms seeking improvement seem to be treating the symptoms but not the disease. The study argues that the debate encounters a conceptual predicament characterized by substantively different conceptions of patent quality, which are influenced by differing normative expectations and assessments of patent systems. It transforms a potentially useful analytical concept into a rabbit hole. Any attempts to break the current impasse must begin with an appreciation of the different senses in which patent quality is used and an assessment of the legitimacy of their underlying normative frameworks.
Hybridisierungstendenzen in Settings der Berufs- und Laufbahnberatung
Authors: Mocigemba Dennis , Unterreiner Laura 
Published: March 2024

ZusammenfassungDer Beitrag analysiert aktuelle Veränderungen der Beratungssettings in der Berufs- und Laufbahnberatung, die durch Mediatisierung und Digitalisierung der Beratung und die Covid-19-Pandemie erheblich forciert wurden und werden. In Anlehnung an bildungswissenschaftliche Überlegungen zu „Hybrid Learning“ werden diese Veränderungen als „Hybridisierungstendenzen“ bezeichnet und als Grenzverschiebungen auf unterschiedlichen Ebenen (räumlich, zeitlich, sozial, institutionell) konzeptualisiert. Auf Basis einer Umfrage unter Bayerischen Berufsberaterinnen und Berufsberatern der Bundesagentur für Arbeit (n = 237) wird dargestellt, welche Hybridisierungstendenzen seit der Pandemie erlebt wurden, welche in der Zukunft erwartet und wie diese bewertet werden.
Evaluating mathematical models for predicting the transmission of COVID-19 and its variants towards sustainable health and well-being
Authors: Sabherwal Amarpreet Kaur , Sood Anju , Shah Mohd Asif 
Published: March 2024

AbstractThis review thoroughly explores numerous key areas contributing to sustainable health and well-being. It encompasses precision medicine, eco-friendly healthcare practices, digital health technologies, holistic well-being approaches, community health promotion, global health protection, and data-driven public health techniques, providing a roadmap for a greater resilient healthcare future. The study evaluates the effectiveness of mathematical modelling in predicting COVID-19 transmission patterns and variants. It starts by providing an overview of COVID-19 and its variants, which include their origins and modes of transmission, then delves into prediction techniques and mathematical modelling, focusing especially on the use of differential equations-based modelling to understand disease progression. The objective is to enhance scientific information of COVID-19 variants and their effect on public health by providing insights, situation analyses, and policy recommendations derived from mathematical modelling. This comprehensive review focuses on serving as a useful resource for researchers, policymakers, and healthcare experts in addressing the pandemic and its evolving variants.
Antiangiogenic therapy: how far is it to upgrade?
Authors: Wang Jing , Li Kai 
Published: March 2024

AbstractEarly vascular-targeted drugs represented by VEGF single-pathway inhibitors pioneered the idea of regulating the tumor growth microenvironment and enhanced the chemotherapy effect in a variety of tumors. However, their shortcomings of “only winning PFS but not OS” have gradually revealed and warned that drug-resistant growth of tumors is unavoidable after long-term use. The activation of intracellular bypass signaling after inhibiting a single target may be an important reason. In order to eliminate this problem, attempts have been made to expand the combination of drug types and increase the intensity of drug treatment. The possibility of replacing single-target anti-angiogenic therapeutic drugs with multiple targets has also be explored. A new generation of “dual-dimension, multi-pathway” drugs that simultaneously inhibit multiple targets both in tumors and microvascular endothelial cells can be used either as single drugs in multiple tumor types, or in combination with chemotherapy, EGFR-TKI, or even immunological drugs. It demonstrates good efficacy and great potential and hope for upgrading vascular targeted therapy. It also enlightens us that future treatment and new drug development strategies cannot rely solely on the most precise target inhibition, but should have a “dual-dimension, multi-pathway” integration concept that looks at the overall situation from one corner.