bluuebunny/crossref_metadata_2025_split huggingface dataset:
The pharmacologic manipulation of blood flow in hyperthermia therapy
Authors: Olch Arthur J. , Silberman Allan W. , Storm F. Kristian , Graham L. Stephan , Morton Donald L. 
Published: February 2007

AbstractMany human tumors treated by hyperthermia do not reach therapeutic temperatures (42°C). The explanation for this difference may be that some tumors react to thermal stress in a manner similar to normal tissues; ie, they increase blood flow during hyperthermia in order to dissipate the heat. Higher temperatures might be achieved in these heat‐resistant tumors by administering vasoconstrictive agents in an effort to reduce blood flow. In this preliminary study, we determined the extent to which pharmacologic inhibition of local blood flow might allow higher temperatures to develop in normal muscles exposed to localized radiofrequency hyperthermia. We found that the local muscle temperature rise could be increased by at least 90% in two dogs and six rabbits with the use of a local vasoconstrictive drug.
Cis‐diamminedichloroplatinum (II): Second line induction chemotherapy in advanced ovarian adenocarcinoma
Authors: Piver M. Steven , Barlow Joseph J. , Lele Shashikant B. , Malfetano John H. , McPhee Mary Eileen 
Published: February 2007

AbstractTwenty‐one evaluable patients received second‐line chemotherapy for recurrent ovarian adenocarcinoma with induction Cisplatin given weekly followed by monthly combination chemotherapy. Forty‐two percent of the patients responded to induction weekly Cisplatin. Of the responders, 77% are alive as compared to only 8% of the nonresponders. Maintenance of the responses by monthly combination chemotherapy remains a significant problem. Moreover, 83% and 70% of patients who received weekly Cisplatin as first‐ and third‐line induction chemotherapy, respectively, had objective responses. Of the total 43 patients who received weekly Cisplatin as first‐, second‐, or third‐line chemotherapy, 60% responded, including complete clinical responses in 14% and partial responses in 46%.
Granular cell tumor of the bronchus: A previously unreported cause of hypercalcemia
Authors: Gabriel Juan B. , Thomas Louys , Kondlapoodi Preetham , Haque Naghmana , Chauhan Prem M. 
Published: February 2007

AbstractHypercalcemia was found in a patient with an endobronchial granular cell tumor. To the best of our knowledge, the association of hypercalcemia and granular cell tumor has not been previously reported in the literature. Resection of the tumor resulted in the return of the serum calcium levels to normal. Investigation of the metabolic status of the patient suggested that the tumor was not producing parathormone.
Clinical and laboratory findings of carcinoma of the pancreas and periampullary structures
Authors: Lee Yeu‐Tsu N.(Margaret) , Williams Mark D. 
Published: February 2007

AbstractThis is a retrospective review of 233 patients who had surgical exploration for proven or suspected malignant lesions of the exocrine pancreas and periampullary structures. There were 24 patients with carcinoma of the ampulla or duodenum, 12 with carcinoma of the bile duct, and 197 with lesions of the pancreas. Among the latter group, 128 patients had carcinoma diagnosed at initial operation (31 by duodenopancreatectomy, 33 by liver, and 64 by other biopsies), and 69 patients had suspected carcinoma of the pancreas without histological proof. History of jaundice, pruritus, nausea/vomiting, total weight loss, duration of pain, and values of blood urea nitrogen, bilirubin, alkaline phosphatase, and albumin were significantly different among the various groups. Patients who had resection of carcinoma of the duodenum or ampulla had the best 5‐year survival rate (39 ± 12%). Among patients with resectable or nonresectable carcinoma of the pancreas, some of the symptoms and laboratory tests studied had prognostic significance.
Pelvic abscess following preoperative radiation and abdominoperineal resection: Management with a free flap
Authors: Kraybill William G. , Reinsch John , Puckett Charles L. , Bricker Eugene M. 
Published: February 2007

AbstractThe case of a woman treated for a large rectal cancer with high‐dose radiation therapy and abdominoperineal resection followed by a large pelvic abscess is presented. Wound healing, reconstruction, and rehabilitation were achieved with a free latissimus dorsi myocutaneous flap. The importance of providing well‐vascularized tissue for wound healing in the infected irradiated wound is emphasized.
Melanoma metastatic to “lipomata”
Authors: Mann Barry D. , Finck Sanford J. , Cohchran Alistair J. , Morton Donald L. 
Published: February 2007

AbstractThree patients presented with solitary melanoma metastases that mimicked a simple “lipomata.” On further investigation each patient had a discrete fatty tissue tumor mass surrounding a melanoma metastasis. The presence of an enlarging mass in patients with a history of melanoma should be viewed with suspicion and a biopsy should be performed.
Surgical treatment of carcinoma of the breast: II. Prognostic factors influencing relapse rate
Authors: Lee YEU‐TSU N. (Margaret) , Chan Linda S. 
Published: February 2007

AbstractThis is a study of 408 patients who had mastectomy for clinical stages I, II, and early III carcinoma of the breast during 1971–1980. Analysis of disease‐free probabilities up to 5 yr showed that the number of positive axillary nodes was the most important prognostic factor. Size of primary tumor was the second most useful factor, with best separation of disease‐free rates using 4 cm as a dividing line. Patients with colloid carcinoma and other less common lesions had much better prognosis than those with infiltrating ductal, lobular, or medullary carcinomas. Discriminating analysis also showed that information about the number of positive axillary node alone gave the best prediction of possibility of developing recurrence (overall accuracy, 75%).
Use of a soft‐agar colony‐forming assay to determine the photosensitizing effects of several components of hematoporphyrin derivative
Authors: Jones C. A. , Uhl C. B. , Mattox V. R. , Kinsey J. H. , Cortese D. A. , Lieber M. M. 
Published: February 2007

AbstractThe photosensitizing/cytotoxic effects of four porphyrin compounds derived from hematoporphyrin were compared using two human tumor cell lines with a soft‐agar colony‐forming assay. Reproducible dose‐ and time‐dependent increases in reproductive cell death were observed for each porphyrin tested. Two fractions derived from hematoporphyrin derivative (HPD) were found to be better photosensitizers than HPD itself, indicating the potential value of this in vitro assay for detecting the most active component from a heterogeneous mixture.
Primary gastrointestinal lymphoma: A review of 21 cases
Authors: Kaufman Z. , Eliashiv A. , Shpitz B. , Witz M. , Griffel B. , Dinbar A. 
Published: February 2007

AbstractA retrospective study of 21 patients who had suffered from gastrointestinal lymphoma was carried out. Gastric involvement was more common than involvement of the small or large intestine and carried a better prognosis. Gastrointestinal lymphoma generally occurs most frequently during the fourth to seventh decades of life. In our study, however, five lymphomas occured in patients under 20 years of age. Clinical symptoms were nonspecific, and abdominal mass was found in only 15% of the patients on clinical examination. All patients were explored, 17 underwent resection, and 4 laparotomy and biopsy. Five‐year survival was much better for patients who had undergone resection. Survival was inversely proportionate to the extent of nodal spread. Multiple lesions on the same organ yielded a 5‐year survival of 20%, while a single lesion offered a 55% chance of 5‐year survival. Diffuse histiocytic lymphoma was the commonest type, followed by the poorly differentiated lymphocytic type. A longer survival rate was present in the lymphocytic type. However, the highest survival rate was in those patients in whom definite resections of the lesion were performed followed by radiation and chemotherapy, especially for gastric tumor.
Local erythema multiforme‐like drug reaction following intravenous mitomycin C and 5‐fluorouracil
Authors: Spencer Henry J. 
Published: February 2007

AbstractA localized skin reaction occurred within 4 weeks following IV adminstration of mitomycin C and 5‐FU. Erythematous papules appeared proximal to the forearm site used for drug administration that histologically resembled an erythema multiforme‐like drug reaction. A localized hypersensitivity reaction to mitomycin C is suspected.
Kidney fibroxanthoma (malignant fibrous xanthoma): A rare tumor and an unusual cause of retroperitoneal hemorrhage
Authors: Witz Misha , Bernheim Joëlle , Dinbar Alex , Griffel Benjamin 
Published: February 2007

AbstractA case of kidney fibroxanthoma (malignant fibrous xanthoma, malignant variant of xanthogranuloma), a rare malignant neoplasm of kidney, is described. In addition to the typical histologic features of retroperitoneal xanthogranuloma, this tumor showed obvious pleomorphism and mitotic activity of the histiocytes. We present this case in view of the rarity of this neoplasm and the unusual presentation as massive retroperitoneal hemorrhage.
Gastric pull‐up for cancers of the hypopharynx and cervical esophagus: Our experience
Authors: Pradhan Sultan A. , Rajpal Ram M. 
Published: February 2007

AbstractTwenty‐five cases of squamous cancer of the hypopharynx and cervical esophagus treated with laryngopharyngoesophagectomy and pharyngogastric anastomosis are presented. In all cases the lesion was such that a complete circumferential pharyngectomy was necessitated. Twelve patients had received full radiation therapy and surgery was undertaken for residual and recurrent disease. Eleven patients had a concurrent unilateral radical neck dissection and two patients a concurrent bilateral neck dissection. Five patients died within 1 month following surgery. The causes of death are discussed. The most notable features of this method of pharyngeal and cervical esophageal reconstruction is the early restoration of swallowing (20 patients were on oral feed in less than 10 days following surgery), a very low incidence of anastomatic leak and subsequent hazards of a carotid hemorrhage (only one patient had a major leak leading to carotid hemorrhage), and absence of subsequent anastomotic stenosis as is seen after reconstruction with skin tubes.
The pathophysiology of the jejunal conduit syndrome and its exacerbation by parenteral hyperalimentation
Authors: Bonnheim David C. , Petrelli Nicholas J. , Sternberg Ahud , Mittelman Arnold 
Published: February 2007

AbstractSupravesical urinary diversion using a jejunal conduit may be associated with hyponatremia, hypochloremic‐acidosis, hyperkalemia, azotemia, and a clinical picture of nausea, vomiting, dehydration, muscular weakness, elevated temperature, and lethargy. This syndrome is secondary to the loss of sodium chloride into the urine passing through the conduit and absorption of potassium and urea from it. Treatment and prevention of this syndrome consist of adequate supplements of sodium chloride and hydration. Intravenous hyperalimentation as the precipitating factor of a severe form of this syndrome and its successful management are described. The pathophysiology of the jejunal conduit syndrome is also discussed. Great selectivity and extreme caution are recommended with respect to the use of intravenous hyperalimentation in patients with jejunal conduits.
Microcytotoxicity blocking assay for the detection and isolation of soluble astrocytoma association antigen
Authors: Potter Virginia P. , Wood William C. , Cohen Alfred M. , Kornblith Paul L. 
Published: February 2007

AbstractA blocking microcytotoxicity assay was used to detect soluble astrocytoma‐associated antigen. The richest source of soluble antigen was found in spent culture media from an established glioblastoma (GF) tissue culture line. Also assayed were fractions of sonicated membrane antigen from another (GM) glioblastoma and pellets of GF and GM cultured glioblastoma tissue. Blocking by media conditioned by cultured normal human brain, breast cancer, neuroblastoma, meningioma, or 2‐year‐old astrocytoma cell lines was 41–82% lower. A monomer was isolated that blocked cytotoxicity and migrated in molecular exclusion chromatography with alpha‐macroglobulins rather than the beta‐2‐microglobulins usually associated with histocompatibility antigens.
Combination chemotherapy for metastatic breast cancer with fluorouracil, adriamycin, cyclophosphamide, and methotrexate
Authors: Aboud Ambrose , Buzdar Aman U. , Yap Hwee‐Yong , Hortobagyi Gabriel N. , Blumenschein George R. 
Published: February 2007

AbstractTwenty‐nine patients with metastatic breast cancer were treated with fluorouracil, adriamycin, cyclophosphamide (FAC), and methotrexate (MTX), with or without leukovorin rescue. Of 24 evaluable patients, one achieved a complete remission and 17 had partial responses. The overall objective response rate was 75%. The median survival from initiation of chemotherapy for the responding patients was 18 months. Four patients (17%) with stable disease had a median survival of 25 months. The addition of MTX to FAC chemotherapy did not improve the therapeutic efficacy of this combination; it did, however, increase the overall toxicity, especially the infectious complications when compared to FAC alone.
Localized laryngeal lymphoma
Authors: Chen Karl T. K. 
Published: February 2007

AbstractA 23‐year‐old man with a 3‐month history of hoarseness was found to have a polypoid histiocytic lymphoma arising from the anterior commissure and the adjacent epiglottis. Work‐ups including a staging laparotomy were negative. Irradiation of 4,400 rads to the larynx was given. The patient was disease‐free 3 1/2 years after diagnosis.
Evaluation of the results of three different methods of postmastectomy lymphedema treatment
Authors: Zanolla R. , Monzeglio C. , Balzarini A. , Martino G. 
Published: February 2007

AbstractThe aim of this study was to evaluate the following methods of postmastectomy lymphedema treatment: pneumatic massage with uniform pressure, pneumatic massage with differentiated pressure, and manual lymphatic massage. The study concerned three groups of 20 mastectomized patients with secondary early developed arm lymphedema. The measurement of circumference on seven points of both arms, the self‐scoring mood questionnaire, and the visual analogue scale (VAS) were evaluated before, at the end, and 3 months after the treatment. We observed a permanent edema reduction, which was statistically significant, with uniform pressure pneumatic massage and with manual lymphatic massage, but not with differentiated pneumatic massage. The VAS and the self‐scoring mood questionnaire made from measuring the subjective ratings of the patients confirmed the objective evaluations.
Treatment of breast carcinoma recurrent after adjuvant chemoimmunotherapy
Authors: Rabadi Sami J. , Haid Max , Scanlon Edward F. , Khandekar Janardan D. , Caprini Joseph A. , Oviedo Miguel A. , Cunningham Myles P. , Grizenko Kerry K. , Cohen Eli 
Published: February 2007

AbstractBetween July 1975 and June 1979, 194 patients with State II or III breast carcinoma were randomized to receive either L‐phenylalanine mustard (L‐PAM), cyclophosphamide and 5‐fluorouracil and prednisolone (CFP), or CFP and BCG. Sixty‐one patients have recurred despite the adjuvant chemoimmunotherapy trial. Fifty‐three are evaluable for survival and 36 for response to chemo‐hormonal therapy. Those treated with a chemo‐hormonal regimen for their first recurrence exhibited a 53% objective response rate to cytotoxic therapy or a 35% response to hormonal therapy. Prior exposure to L‐PAM, cyclophosphamide, or 5‐fluorouracil did not preclude response to ‘salvage’ therapy regimens containing those agents. Neither menopausal status, estrogen receptor content, size of the primary tumor, adjuvant treatment, nor extent of the recurrence had any effect on subsequent survival. Overall, the entire group exhibitied median survival of 37 months from initial diagnosis and 13 months from recurrence. Unlike recurrent Hodgkin's disease, there was no demonstrable relationship between the length of the disease‐free interval and the likelihood of subsequent response to cytotoxic or hormonal treatment. Comparison is made to the results of ‘salvage’ therapy administered after three other large adjuvant treatment series.
The effect of 1,2‐dimethylhydrazine (DMH) carcinogenesis on peripheral T cell subsets in the wistar furth rat
Authors: Ross Donald S. , Steele Glenn , Rodrick Mary L. , Milford Edgar , Bleday Ronald S. , Lahey Stephen J. , Deasy Joseph M. , Rayner Anthony A. , Wilson Richard E. 
Published: February 2007

Abstract1,2‐dimethylhydrazine (DMH)‐induced colon cancer in Wistar/Furth (W/Fu) rats is analogous in many ways to human colorectal cancer. As part of our attempt to understand the immunobiology of these tumors, we have utilized the recently available monoclonal antibodies W3/25 and OX8 to monitor helper (Th) and suppressor (Ts) lymphocyte subpopulations. Normal untreated male W/Fu rats of less than 1 year of age were pheno‐typed (n = 43). The mean percentage of Th and Ts was 42 ± 1 (mean = SEM) and 33 ± 1, respectively. The mean Th/Ts ratio was 1.3 ± 0.1. A Th/Ts equal to or greater than 1 is considered ‘normal’ in the W/Fu rat. The DMH‐treated rats (20 mg/kg/wk) were evaluated in initial experiments at various intervals after treatment. Rats studied 24 hours after a single DMH injection had no alterations in T cell subsets. Rats studied 28, 32, and 65 weeks after the start of 16 weekly DMH injections were found to have a decrease in the percentage of Th and a relative increase in Ts, with Th/Ts ratios of 0.6 ± 0.2, 0.7 ± 0.1, and 0.7 ± 0.1, respectively (each P < 0.01). In a separate experiment in which rats were studied after 4, 8, and 16 weeks of DMH injections, no alterations in T cell subsets were noted. Rats (n = 5) studied at 20 weeks after the start of DMH were found to have 41 ± 3% Th and 36 ± 2% Ts and a Th/Ts ratio of 1.2 ± 0.1. Three of five rats were found to have adenocarcinomas. Four of five rats had Th/Ts less than 1. One rat with Th/Ts equal to 0.9 had metastatic disease. Rats studied at 25 weeks (n = 8) were found to have more advanced carcinomas (4/8) that were causing obstruction or bleeding in the animal. There was a significant decrease in Th and Ts in this group, with 24 ± 3% and 26 ± 3% respectively (P < 0.001). The Th/Ts ratio for this group was 0.9 ± 0.1 (P < 0.01). In other experiments, rats were treated with DMH or placebo over a 16‐week period and serially bled during and after treatment. No effect of DMH treatment on T cell subsets was noted. Repeated bleeding alone was noted to cause persistent alterations of T cell subpopulation. In conclusion, DMH treatment does not appear to cause changes in peripheral T cell subset changes prior to the onset of tumor development. Even when small tumors are present, the proportions of Th and Ts are normal unless the animals are bleeding or are obstructed. Likewise, animals with metastatic disease appeared to have T cell population changes. It may be that DMH causes changes in local, ie, gut associated lymphoid tissue that may be causally related to tumor development. This possibility is currently under investigation.
Influence of a reticuloendothelial‐suppressing agent on liver tumor growth in the rat
Authors: Rydén Stefan , Bergqvist Lennart , Hafström Larsolof , Hultberg Björn , Stenram Unne , Strand Sven‐Erik 
Published: February 2007

AbstractReticuloendothelial (RE) function was evaluated by measuring the biokinetics of a standardized 99Tcm‐sulphur colloid. Methyl palmitate was administered intravenously on two consecutive days. A statistically significant reduction in the colloid uptake rate of the liver was registered after methyl palmitate administration. Histological examination revealed no signs of destruction of RE cells or microembolization. Inoculation of an experimental nitrosoguanidine‐induced transplantable adenocarcinoma to the liver was performed in 16 rats one day after methyl palmitate administration and in 16 controls. Tumor size was significantly larger in methylpalmitate‐treated animals at 7 and 14 days after inoculation. Survival was significantly decreased in methyl‐palmitate‐treated rats. These rats showed signs of fatty vacuolization and necrosis of liver parenchyma earlier than controls. Analyses of β‐hexosaminidase and lactate dehydrogenase revealed no deviation of enzyme levels either before or after tumor inoculation. The results indicate that a temporary suppression of RE function at the time of tumor inoculation may influence subsequent tumor growth.
Ovarian teratoma with peritoneal and lymph node metastases of mature glial tissue: A benign condition
Authors: Shafie M. El , Furay Richard W. , Chablani L. V. 
Published: February 2007

AbstractThe presence of widespread intraperitoneal metastases in patients with ovarian tumors usually indicates advanced disease. However, this is not always the case. A rare type of ovarian tumor, ie, mature solid teratoma, may be associated with intraabdominal metastases of mature glial tissue (gliomatosis peritonei). In spite of such metastases, the prognosis in patients with this tumor is excellent, regardless of the mode of therapy. In these patients radical surgical treatment, eg, bilateral salpingo‐oophorectomy, is unnecessarily destructive, and therapy for the metastases is not required.
Tumor embolism as the first manifestation of cancer
Authors: Burchard Kenneth W. , Carney Wilfred I. 
Published: February 2007

AbstractMajor tumor emboli (obstructing segmental or larger branches of the pulmonary artery) are a rare mechanism of spread of cancer to the lungs. Less frequently are tumor emboli the cause of respiratory failure and death. The present case of major tumor embolism as the initial manifestation of cancer is unusual for the chronicity, documentation of recurrence, and tissue pathology encountered. In retrospect, we can describe clues which may arouse suspicion of tumor embolism in future cases.
Surgical treatment of carcinoma of the breast: IV. prognosis according to extent of involvement of the axillary lymph nodes
Authors: Lee Yeu‐Tsu N.(Margaret) , Chan Linda S. 
Published: February 2007

AbstractThis is a retrospective study of 462 patients who had masectomy and axillary dissection for carcinoma of the breast during 1971‐1980. Actuarial analysis of relapse rates up to 5 years showed that the extent of involvement of axillary lymph nodes was the most important prognostic factor. Among patients without any axillary metastasis, those with tumor smaller than 2 cm, colloid, or other less common carcinomas had significantly better prognosis than those with other lesions. Patients younger than 45 years old had higher relapse rate. Among patients with four or more positive axillary nodes, those with tumors smaller than 9 cm or those with nine or fewer positive nodes also had lower relapse rate than those with larger tumors or more positive nodes. Adjuvant systemic chemotherapy has improved the prognosis of patients with four or more positive nodes. Our findings are discussed and compared to those reported in the literature.
The management of cardiac tamponade in patients with breast cancer
Authors: Bitran Jacob D. , Evans Richard , Brown Charles 
Published: February 2007

AbstractSix patients with disseminated breast cancer and cardiac tamponade were treated with a pleuropericardial window and in four patients with systemic chemotherapy. The median survival of these six patients was 17 months (range 1‐50 months). These results indicate that aggressive therapy in patients with cardiac tamponade and breast cancer can lead to prolonged survivals.