bluuebunny/crossref_metadata_2025_split huggingface dataset:
Plasma sCD146 is a potential biomarker for acute exacerbation of chronic obstructive pulmonary disease
Authors: Jia Xinyu , Jiang Jingxian , Yang Chen , Zhang Sujuan , Wu Jingjing , Ma Qiyun , Wang Zhengxia , Chen Zhongqi , Zhang Mingshun , Huang Mao , Ji Ningfei 
Published: March 2024

AbstractThis study examined the levels of soluble CD146 (sCD146) in plasma samples from patients with chronic obstructive pulmonary disease (COPD) and assessed the relationship between sCD146 and the severity of COPD. A total of 97 COPD patients were recruited from 20 medical centers in Jiangsu, China, including 13 stable subjects and 84 exacerbated subjects. The plasma sCD146 level in exacerbated subjects (28.77 ± 10.80 ng/mL) was significantly lower than that in stable subjects (38.84 ± 15.00 ng/mL). In the high sCD146 group, the proportion of subjects with modified Medical Research Council (mMRC) scores of 0–1 was higher, the proportion of subjects with the Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage 4 was lower, and the proportion of subjects with ≥1 hospitalizations in the past year was lower. The plasma sCD146 level was negatively correlated with the COPD Assessment Test (CAT) score (r = −0.2664, p = 0.0087). Logistic regression analysis showed that sCD146 was an independent risk factor for acute exacerbation of COPD (AECOPD). Receiver operating characteristic (ROC) analysis suggested that sCD146 combined with sex, age, pulmonary function, and acute exacerbations in the past year had clinical value for the accurate identification of AECOPD, with an area under the ROC curve (AUC) of 0.908 (95% CI: 0.810–1.000, p < 0.001). In addition, there was a significant negative correlation between plasma sCD146 and S100A9 (r = −0.3939, p < 0.001).
Genetic predisposition and high exposure to colistin in the early treatment period as independent risk factors for colistin‐induced nephrotoxicity
Authors: Mathew Sumith K. , Chapla Aaron , Venkatesan Padmanaban , Eriyat Vishnu , Aruldhas Blessed Winston , Prabha Ratna , Neely Michael N. , Rao Shoma V. , Kandasamy Subramani , Mathew Binu Susan 
Published: March 2024

AbstractColistin is known to cause nephrotoxicity due to its extensive reabsorption and accumulation in renal tubules. In vitro studies have identified the functional role of colistin transporters such as OCTN2, PEPT2, megalin, and P‐glycoprotein. However, the role of these transporter gene variants in colistin‐induced nephrotoxicity has not been studied. Utilizing targeted next‐generation sequencing, we screened for genetic polymorphisms covering the colistin transporters (SLC15A1, SLC15A2, SLC22A5, LRP2, and ABCB1) in 42 critically ill patients who received colistimethate sodium. The genetic variants rs2257212 ((NM_021082.4):c.1048C>G) and rs13397109 ((NM_004525.3):C.7626C > T) were identified as being associated with an increased incidence of acute kidney injury (AKI) on Day 7. Colistin area under the curve (AUC) was predicted using a previously published pharmacokinetic model of colistin. Using logistic regression analysis, the predicted 24‐h AUC of colistin was identified as an important contributor for increased odds of AKI on Day 7. Among 42 patients, 4 (9.5%) were identified as having high predisposition to colistin‐induced AKI based on the presence of predisposing genetic variants. Determination of the presence of the abovementioned genetic variants and early therapeutic drug monitoring may reduce or prevent colistin‐induced nephrotoxicity and facilitate dose optimization of colistimethate sodium.
Foreign Ownership and International Trade Performance in China
Authors: Li Zhiyuan , Lin Yichun , Xu Mingyao 
Published: March 2024

AbstractWe investigate the causal relationship between foreign ownership and international trade performance by comparing foreign‐acquired firms with similar domestic‐acquired firms in China with regard to changes in their post‐acquisition international trade performance. Our findings indicate that foreign ownership significantly enhanced the probability of both exporting and importing, and strongly increased trade value. Foreign ownership took effect from the year of the acquisition and persisted for at least 2 years. It stimulated both processing trade and ordinary trade, and expanded products and trading partners. Post‐acquisition trade performance also exhibited heterogeneity based on the different pre‐acquisition and post‐acquisition ownership. As for the underlying mechanisms, we show that firms experienced significant output expansion, increased export dependence, and eased financial constraints after foreign acquisition.
Whose Aid is Beneficial to Firms' Exports? Evidence from a Post‐disaster Aid Experiment in China
Authors: Li Tan , Liu Qing , Xu Lihe 
Published: March 2024

AbstractPost‐disaster aid is widely regarded as important in helping local recovery and development. This paper examines the effectiveness of post‐disaster aid on exports, which are a driving factor of economic development. It reports a natural experiment in China – the case of post‐disaster aid following the Wenchuan earthquake in 2008 – to examine how donors' experiences affected the exports of manufacturing firms in disaster‐stricken counties. The export experience of the donor was important. Aid coming from donors with more export experience was more beneficial to the exports of firms in recipient counties than aid from less experienced donors. “Learning from the donor” is a potential channel through which this effect occurred. That is, firms in recipient counties learned from donors' export experience by exporting more products similar to those of donors, exporting more to the destination countries of donors, and participating in the donors' supply‐chain networks by exporting more of the donors' exports. Such “learning from the donor” effects show that knowledge spillover can occur between spatially distant parties, which complements the literature.
Efficacy of topiramate in reducing second‐generation antipsychotic‐associated weight gain among children: A systematic review and meta‐analysis
Authors: Costa Gabriel P. A. , Moraes Vitor R. Y. , Assunção Beatriz R. , Burns Nora , Laique Sobia , Sengupta Shreya , Anand Akhil , Nunes Julio C. 
Published: March 2024

AbstractAimsTo conduct a systematic review and meta‐analysis with the aim of synthesizing existing data on the efficacy and safety of topiramate as an adjunctive treatment for reducing second‐generation antipsychotic (SGA)‐associated weight gain in children aged 4–18 years.MethodsWe conducted a comprehensive search of PubMed, Embase, PsychNet and Web of Science from time of their inception up to 12 February 2024, including randomized controlled trials that compared SGA treatment with and without topiramate co‐administration in children. The primary outcomes were changes in body weight and body mass index (BMI). Heterogeneity was assessed using I2 statistics.ResultsThis systematic review included five randomized trials, totalling 139 participants (43.9% female; mean [SD] age 11.9 [3.5] years). Four of these trials were included in the meta‐analysis, comprising 116 subjects. We found that topiramate was significantly effective both in reducing SGA‐associated weight gain, with a mean difference of −2.80 kg (95% confidence interval [CI] −5.28 to −0.31; p = 0.037, I2 = 86.7%) and a standardized mean difference (SMD) of −1.33 (95% CI −2.14 to −0.51; p = 0.014, I2 = 31.7%), and in reducing BMI change compared to placebo (SMD −1.90, 95% CI −3.09 to −0.70; p = 0.02, I2 = 0%). Sedation risk was lower with topiramate than with placebo (odds ratio 0.19, 95% CI 0.11–0.32; p < 0.01, I2 = 0%). No significant differences were found in dropouts, any other side effects, and metabolic parameters, such as triglycerides, total cholesterol, low‐density lipoprotein, high‐density lipoprotein, and glucose. None of the included studies reported assessments on cognitive side effects.ConclusionThis meta‐analysis suggests that topiramate is an effective and safe option for mitigating SGA‐associated weight gain in children.
Didactic strategies for the education of computational thinking from a gender perspective: A systematic review
Authors: Torres‐Torres Yucnary‐Daitiana , Román‐González Marcos , Perez‐Gonzalez Juan‐Carlos 
Published: March 2024

AbstractComputational Thinking (CT) is crucial for the advancement of the STEM field, where there continues to be a lack of female representation. Teaching and learning (T/L) of CT should incorporate didactic strategies that aim to eliminate gender biases and integrate girls/women into this context. In response to the question, “What didactic strategies have been implemented in the T/L of CT in primary and secondary education?”. A systematic review was conducted following a PRISMA protocol specifically designed for this review. The study analysed Didactic Strategies (DS) and examined whether they incorporated the so‐called “minimum actions” (MA) proposed in this article as a strategy to integrate females into CT. The findings revealed a limited number of studies that implemented these actions. In conclusion, there is an urgent need to continue developing DS that incorporate these MA to effectively integrate girls and women into CT, allowing them to play a central role in its advancement and development.
Migraine, idiopathic intracranial hypertension, and calcitonin gene‐related peptide antibodies
Authors: Krikova Irina , Digre Kathleen B. , Katz Bradley J. , Seay Meagan D. , Warner Judith E.A. 
Published: March 2024

Plain language summaryIdiopathic intracranial hypertension (IIH) is a condition of high pressure in the spinal fluid that is common in young women who are overweight or obese. Headache happens in most individuals with IIH and can continue after the early phase of IIH has resolved. We studied the use of a newer type of medication developed for migraine called calcitonin gene‐related peptide antibodies and we found that these medications can be helpful for patients who have had IIH, although studies with more patients will be helpful.
An artificial intelligence‐powered PD‐L1 combined positive score (CPS) analyser in urothelial carcinoma alleviating interobserver and intersite variability
Authors: Lee Kyu Sang , Choi Euno , Cho Soo Ick , Park Seonwook , Ryu Jeongun , Puche Aaron Valero , Ma Minuk , Park Jongchan , Jung Wonkyung , Ro Juneyoung , Kim Sukjun , Park Gahee , Song Sanghoon , Ock Chan‐Young , Choe Gheeyoung , Park Jeong Hwan 
Published: March 2024

AimsImmune checkpoint inhibitors targeting programmed death‐ligand 1 (PD‐L1) have shown promising clinical outcomes in urothelial carcinoma (UC). The combined positive score (CPS) quantifies PD‐L1 22C3 expression in UC, but it can vary between pathologists due to the consideration of both immune and tumour cell positivity.Methods and ResultsAn artificial intelligence (AI)‐powered PD‐L1 CPS analyser was developed using 1,275,907 cells and 6175.42 mm2 of tissue annotated by pathologists, extracted from 400 PD‐L1 22C3‐stained whole slide images of UC. We validated the AI model on 543 UC PD‐L1 22C3 cases collected from three institutions. There were 446 cases (82.1%) where the CPS results (CPS ≥10 or <10) were in complete agreement between three pathologists, and 486 cases (89.5%) where the AI‐powered CPS results matched the consensus of two or more pathologists. In the pathologist's assessment of the CPS, statistically significant differences were noted depending on the source hospital (P = 0.003). Three pathologists reevaluated discrepancy cases with AI‐powered CPS results. After using the AI as a guide and revising, the complete agreement increased to 93.9%. The AI model contributed to improving the concordance between pathologists across various factors including hospital, specimen type, pathologic T stage, histologic subtypes, and dominant PD‐L1‐positive cell type. In the revised results, the evaluation discordance among slides from different hospitals was mitigated.ConclusionThis study suggests that AI models can help pathologists to reduce discrepancies between pathologists in quantifying immunohistochemistry including PD‐L1 22C3 CPS, especially when evaluating data from different institutions, such as in a telepathology setting.
Associations of radiologic characteristics of the neonatal hypothalamus with early life adiposity gain
Authors: Sewaybricker Leticia E. , Melhorn Susan J. , Entringer Sonja , Buss Claudia , Wadhwa Pathik D. , Schur Ellen A. , Rasmussen Jerod M. 
Published: March 2024

SummaryBackgroundThe mediobasal hypothalamus (MBH) is a key brain area for regulation of energy balance. Previous neuroimaging studies suggest that T2‐based signal properties indicative of cellular inflammatory response (gliosis) are present in adults and children with obesity, and predicts greater adiposity gain in children at risk of obesity.Objectives/MethodsThe current study aimed to extend this concept to the early life period by considering if, in full‐term healthy neonates (up to n = 35), MRI evidence of MBH gliosis is associated with changes in early life (neonatal to six months) body fat percentage measured by DXA.ResultsIn this initial study, neonatal T2 signal in the MBH was positively associated with six‐month changes in body fat percentage.ConclusionThis finding supports the notion that underlying processes in the MBH may play a role in early life growth and, by extension, childhood obesity risk.
Parecoxib decreases cellular growth and Bcl‐2 protein levels in primary cultures of keloid fibroblasts
Authors: Grella Roberto , Lanzano Giuseppe , Faenza Mario , Ferraro Giuseppe , Pieretti Gorizio 
Published: March 2024

AbstractKeloids seem to overexpress cyclo‐oxygenase‐2 (COX‐2), suggesting a role in its deregulated pathway in inducing an altered epithelial‐mesenchymal interaction, which may be responsible for the overgrowth of dermal components resulting in scars or keloid lesions. This study aimed to evaluate the effect of Parecoxib, a COX‐2 inhibitor, on cell growth in fibroblast primary cultures obtained from human keloid tissues. Tissue explants were obtained from patients who underwent intralesional excision of untreated keloids; central fractions were isolated from keloid tissues and used for establishing distinct primary cultures. Appropriate aliquots of Parecoxib, a COX‐2 inhibitor were diluted to obtain the concentration used in the experimental protocols in vitro (1, 10 or 100 μM). Treatment with Parecoxib (at all concentrations) caused a significant decrease in cellular growth from 24 hours onwards, and with a maximum at 72 hours (P < .02). Moreover, at 72 hours Parecoxib significantly reduced cellular vitality. Parecoxib treatment also induced an increase in fragmented nuclei with a maximum effect at 100 μM and a significant decrease in Bcl‐2 and an increase in activated caspase‐3 protein levels at 72 hours compared with control untreated cultures. Our findings suggest a potential use of the COX‐2 inhibitor, Parecoxib, as the therapy for keloids.
The RING zinc finger protein LbRZF1 promotes salt gland development and salt tolerance in Limonium bicolor
Authors: Yang Zongran , Zhang Ziwei , Qiao Ziqi , Guo Xueying , Wen Yixuan , Zhou Yingxue , Yao Chunliang , Fan Hai , Wang Baoshan , Han Guoliang 
Published: March 2024

ABSTRACTThe recretohalophyte Limonium bicolor thrives in high‐salinity environments because salt glands on the above‐ground parts of the plant help to expel excess salt. Here, we characterize a nucleus‐localized C3HC4 (RING‐HC)‐type zinc finger protein of L. bicolor named
RING
ZINC
FINGER PROTEIN
1 (LbRZF1). LbRZF1 was expressed in salt glands and in response to NaCl treatment. LbRZF1 showed no E3 ubiquitin ligase activity. The phenotypes of overexpression and knockout lines for LbRZF1 indicated that LbRZF1 positively regulated salt gland development and salt tolerance in L. bicolor. lbrzf1 mutants had fewer salt glands and secreted less salt than did the wild‐type, whereas LbRZF1‐overexpressing lines had opposite phenotypes, in keeping with the overall salt tolerance of these plants. A yeast two‐hybrid screen revealed that LbRZF1 interacted with LbCATALASE2 (LbCAT2) and the transcription factor LbMYB113, leading to their stabilization. Silencing of LbCAT2 or LbMYB113 decreased salt gland density and salt tolerance. The heterologous expression of LbRZF1 in Arabidopsis thaliana conferred salt tolerance to this non‐halophyte. We also identified the transcription factor LbMYB48 as an upstream regulator of LbRZF1 transcription. The study of LbRZF1 in the regulation network of salt gland development also provides a good foundation for transforming crops and improving their salt resistance.
Hypoalbuminemia, but not derived neutrophil to lymphocyte ratio (dNLR), predicts overall survival in neuroendocrine tumours undergoing peptide receptor radionuclide therapy: A retrospective, cohort study of 557 patients
Authors: Papantoniou Dimitrios , Fröss‐Baron Katarzyna , Garske‐Román Ulrike , Sundin Anders , Thiis‐Evensen Espen , Grönberg Malin , Welin Staffan , Tiensuu Janson Eva 
Published: March 2024

AbstractSeveral inflammation scores have shown association with survival outcomes for patients with neuroendocrine tumours (NET) treated with peptide receptor radionuclide therapy (PRRT). However, whether these scores add value to established prognostic factors remains unknown. In this retrospective, cohort study of 557 NET patients undergoing PRRT in a tertiary referral centre from 2005 to 2015, we examined inflammatory markers and scores previously associated with cancer outcomes, using Cox proportional hazard models and Akaike's information criterion. Lower albumin (hazard ratio [95% confidence interval], .91 [.87–.95] per unit), as well as higher C‐reactive protein (CRP; 1.02 [1.01–1.02]), Glasgow Prognostic Score (GPS; 1 vs. 0: 1.67 [1.14–2.44], 2 vs. 0 3.60 [2.24–5.79]), CRP/albumin ratio (1.84 [1.43–2.37]) and platelet count (Plt) × CRP, but not white blood cell, neutrophil and thrombocyte counts or derived neutrophil to lymphocyte ratio (dNLR), were associated with shorter median overall survival (OS) in an adjusted analysis. The addition of parameters based on albumin and CRP, but not dNLR, to a base model including age, chromogranin A, the cell proliferation marker Ki‐67, performance status, tumour site and previous treatments improved the predictive accuracy of the base model. In an exploratory analysis of patients with available erythrocyte sedimentation rate (ESR) and CRP, ESR emerged as the most powerful predictor. When added to a prognostic model for OS in NET patients treated with PRRT, most inflammation scores further improved the model. Albumin was the single marker adding most value to the set of established prognostic markers, whereas dNLR did not seem to improve the model's prognostic ability.
Impact effects of COVID‐19 pandemic on chronic disease patients: A longitudinal prospective study
Authors: García‐Lara Rubén A. , Suleiman‐Martos Sami , Dominguez‐Vías Germán , Romero‐Béjar José Luis , Garcia‐Morales Victoria , Gómez‐Urquiza José Luis , Suleiman‐Martos Nora 
Published: March 2024

AbstractAimsTo assess the effects of COVID‐19 pandemic on clinical variables as part of the routine clinical monitoring of patients with chronic diseases in primary care.DesignA prospective longitudinal study was conducted in primary care centres of the Andalusian Health Service.MethodsData were recorded before the pandemic (T1), during the declaration of the state of emergency (T2) and in the transition phase (T3). The Barthel index and the Short Portable Mental Status Questionnaire (SPMSQ) were used to analyse functional and cognitive changes at the three time points. HbA1c, systolic and diastolic blood pressure, heart rate, BMI and lipid levels were assessed as clinical variables. Descriptive statistics and non‐parametric chi‐square test were used for analysis. STROBE checklist was used for the preparation of this paper.ResultsA total fo148 patients with chronic conditions were included in the analysis. Data analysis revealed in T2 only significant reductions in BMI, total levels of cholesterol and HDL during the onset of the pandemic. Barthel Index, SPMSQ, blood pressure and triglycerides and LDL levels worsened in T2, and the negative effects were maintained in T3. Compared to pre‐pandemic values, HbA1c levels improved in T3, but HDL levels worsened.ConclusionsCOVID‐19 has drastically disrupted several functional, cognitive and biological variables. These results may be useful in identifying clinical parameters that deserve closer attention in the case of a new health crisis. Further studies are needed to assess the potential impacts of each specific chronic condition.ImpactCognitive and functional status, blood pressure and triglycerides and LDL levels worsen in short term, maintaining the negative effects in medium‐term.
Honokiol induces ferroptosis in ovarian cancer cells through the regulation of YAP by OTUB2
Authors: Liu Fang , Zhang Yufang , Xia Xinyi , Han Jing , Cao Linyan 
Published: March 2024

AbstractBackgroundOvarian cancer (OVCA) is prevalent in female reproductive organs. Despite recent advances, clinical outcomes remain poor, warranting fresh treatment avenues. Honokiol has an inhibitory effect on proliferation, invasion, and survival of cancer cells in vitro and in vivo. Therefore, this study intended to explore specific molecular mechanism by which honokiol affected OVCA progression.MethodsBioinformatics analyzed the drug honokiol that bound to OTU deubiquitinase, ubiquitin aldehyde binding 2 (OTUB2). Cellular thermal shift assay (CETSA) verified the binding relationship between honokiol and OTUB2. Cell counting kit 8 (CCK‐8) tested the IC50 value and cell viability of OVCA cells after honokiol treatment. Corresponding assay kits determined malonic dialdehyde (MDA) and Fe2+ levels in OVCA cells. Flow cytometry measured reactive oxygen species levels. Western blot detected OTUB2, SLC7A11, and transcriptional co‐activators Yes‐associated protein (YAP) expression, and quantitative polymerase chain reaction (qPCR) detected OTUB2 expression. Immunohistochemistry (IHC) detected the expression level of Ki67 protein in tumor tissues.ResultsHonokiol was capable of inducing ferroptosis in OVCA cells. CETSA confirmed that honokiol could bind to OTUB2. Further cell functional and molecular experiments revealed that honokiol induced ferroptosis in OVCA cells via repression of YAP signaling pathway through binding to OTUB2. In addition, in vivo experiments have confirmed that honokiol could inhibit the growth of OVCA.ConclusionHonokiol induced ferroptosis in OVCA cells via repression of YAP signaling pathway through binding to OTUB2, implicating that OTUB2 may be an effective target for OVCA treatment, and our study results may provide new directions for development of more effective OVCA treatment strategies.
Bridging semantics and medical ontology in the definition of bruxism: An argument for a holistic definition
Authors: Skarmeta Nicolás P. 
Published: March 2024

AbstractObjectiveThe objective of this commentary is to advocate for a holistic, ontology‐based definition of bruxism. The intention is to synthesise the best aspects of current definitions into a structured ontological model, thereby refining and enhancing a comprehensive understanding of the full spectrum of bruxism.Materials and MethodsThe commentary elaborates on the process of integrating these insights into a hierarchical ontology that aligns with ontological principles.Settings and Sample PopulationNot directly applicable as this is a commentary.Results/ConclusionThe proposed ontology‐based definition of bruxism aims to clarify communication within the medical community and advance research by enabling a comprehensive ontology‐based classification of bruxism. By aligning with ontological principles, this approach aspires to act as a catalyst for further research, discussion and consensus in the field.