bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nephrogenic diabetes insipidus: potential treatments and their mechanisms of action.
Authors: Alabeedi Siraj , Elkawafi Mohamed 
Published: February 2025

Nephrogenic diabetes insipidus (NDI) is a rare disease caused by the complete or partial resistance of the kidneys to antidiuretic hormone (ADH). NDI associated with excessive urine production and severe thirst. There are two types of NDI; acquired NDI and congenital NDI. Acquired NDI is the most common type among adults, with several factors that can cause acquired NDI, for instance, lithium therapy and electrical disorders. Congenital NDI can occur due to mutations in either the arginine vasopressin receptor 2 (AVPR2) gene or the aquaporin-2 (AQP2) gene. New effective treatments for NDI are required because the disease can be life treating if left untreated. Current animal studies showed that rolipram and metformin are two potential treatments for congenital NDI by upregulation the apical expression of AQP2 channels. Other animal studies illustrated that the combination of different drugs, such as, secretin agonist and fluvastatin could be an effective method to treat XNDI. Furthermore, some agents were found to be able to treat more than one type of NDI, for example, sildenafil citrate could be potently used to treat acquired NDI and XNDI, while statins could be promising treatments for congenital NDI and autosomal NDI. However, further investigation and human trials are needed before it can be decided if these drugs can be clinically used as a treatment for NDI.
Proses Pembentukan Ragam Gaul Generasi Alpha di Media Sosial Tiktok
Authors: Kartika Dwi Ayu , Mualafina Rawinda Fitrotul , Prayogi Icuk 
Published: February 2025

Bahasa gaul atau ragam bahasa gaul merupakan bahasa yang digunakan oleh remaja yang setiap generasinya menunjukan penggunaan ragam bahasa gaul yang berbeda. Seperti halnya setiap remaja pada generasi tertentu mempunyai ciri khasnya masing-masing seperti pada remaja generasi alpha. Tujuan dari penelitian ini, yaitu mendeskripsikan proses pembentukan ragam bahasa gaul generasi alpha pada media sosial tiktok yang terdapat pada akaun @uplkp, @shaidinamaulana, @mrci.tv, @danielalvinjr dan @icha.lovely. Pendekatan yang digunakan, yaitu dengan metode deskriptif kualitatif. Teknik pengumpulan data dalam penelitian ini menggunakan teknik simak bebas libat cakap (SBLC) dan teknik catat. Teknik analisis yang digunakan yaitu dengan teknik padan, teknik yang digunakan untuk analisis bahasa dari faktor eksternal. Dalam hal ini faktor eksternalnya adalah faktor sosial dari penggunaan ragam gaul generasi alpha dan menarik kesimpulan. Hasil penelitian yang dilakukan yakni terdapat beberapa proses pembentukan ragam bahasa gaul pada generasi alpha yang ditemukan, diantaranya: (1) kata tunggal, (2) frasa, (3) singkatan, (4) pemendekan, dan (5) kata berafiks -ing
Analisis Sistem Pengelolaan Pengaduan Pelayanan Publik Nasional Mencegah Maladministrasi pada Sekretariat Daerah Kabupaten Jeneponto
Authors: Maldun Syamsuddin , Suaib Muhmmad Ridho , Afrisal Ade ferry 
Published: February 2025

Layanan SP4N_LAPOR merupakan layanan integrasi aduan digital diciptakan untuk menghasilkan pengelolaan aduan masyarakat yang komunal. Penerapan SP4N_LAPOR di Kabupaten Jeneponto mengakibatkan adanya perubahan mekanisme dan pelaksana pengelola aduan di Kabupaten Jeneponto. Sejak mengalami pengembangan pada tahun 2021, SP4N_LAPOR secara teknis menghapus tatanan unit pengelola aduan (UP4). SP4N_LAPOR merubah pelaksanaan pengelolaan aduan dan aspirasi masyarakat di wilayah Kabupaten Jeneponto. Selain itu, pemerintah masih sempat mengalami fluktuasi dalam mengenalkan layanan sejak awal penerapan belum merambah menggunakan SP4N_LAPOR. Jenis penelitian yang digunakan yaitu fenomenologis dan pendekatan kualitatif. Metode pengumpulan data yang dipakai adalah trianggulasi yaitu: survey, interviuw, dan analisis dokumen. Analisis data menggunakan koleksi data, kondensasi data, penyajian data, verifikasi dan penarikan kesimpulan. Hasil penelitian menunjukkan Kabupaten Jeneponto telah mengimplementasikan adanya good governance melalui SP4N_LAPOR yang berjalan cukup baik antara pemerintah dengan masyarakat di Kabupaten Kendal. Namun, terdapat penghambat dan kendala dalam implementasi tersebut seperti sosialisasi yang kurang masif dan menyasar seluruh masyarakat, keterbatasan anggaran dan kurang responsifnya beberapa admin OPD sehingga menyebabkan laporan aduan dan aspirasi masyarakat belum secara menyeluruh terkelola dan hasil penanganan aduan fluktuatif serta banyak masyarakat yang belum mengetahui SP4N_LAPOR.
Makna Laba Bagi Kelompok Tenun Lo`A Ulimuri
Authors: Indryani Yulista , Kado Kristina Valen , Asmara  
Published: February 2025

Penelitian ini bertujuan untuk mengeksplorasi makna laba bagi kelompok tenun Lo`a Ulimuri, dengan fokus pada bagaimana laba dipersepsikan dan dimanfaatkan oleh para pelaku usaha dalam komunitas ini. Menggunakan pendekatan kualitatif, penelitian ini melibatkan wawancara mendalam Bersama anggota kelompok tenun untuk menggali pandangan mereka mengenai laba. Hasil penelitian menunjukkan bahwa bagi kelompok tenun Lo`a Ulimuri, laba tidak hanya dipandang sebagai pemenuhan kebutuhan finansial, tetapi juga sebagai simbol warisan budaya. Laba dianggap penting untuk mensejahterakan anggota kelompok, memperkuat ikatan sosial dengan menjalin tali kasih persaudaraan dalam suka maupun duka, dan melestarikan warisan budaya tenun. Penelitian ini mengungkapkan makna laba yang lebih luas dan mendalam, mencakup dimensi sosial, budaya, dan ekonomi. Temuan ini memberikan wawasan tentang pentingnya laba dalam konteks budaya dan komunitas, serta dampaknya bagi strategi pemberdayaan ekonomi yang berkelanjutan dan inklusif.
Pengaruh Penggunaan Media Kahoot Terhadap Hasil Belajar Materi Keragaman Suku Bangsa dan Budaya pada Siswa Kelas IV UPT SD Negeri 232 Gresik
Authors: Wulandari Diah Ayu , Suprihatien Suprihatien , Yuanta Friendha 
Published: February 2025

This study aims to determine the influence of the use of Kahoot media on the learning outcomes of ethnic and cultural diversity materials. This study uses a quantitative approach with a type of quasi experiment research whose population is all grade IV students, which is divided into two groups, namely class IV A with 14 students as the experimental group and class IV B with 13 students as the control group. The data collection technique used is a test in the form of multiple-choice questions. Validity and reliability tests are carried out to test the instrument. Furthermore, a normality test was carried out with the results of the variable =2,26, the variable while , while the results of the postes homogeneity test this was stated that both variables were declared to be normally distributed and homogeneous. To find out whether or not there is an influence of Kahoot media in learning, the results of which showed that the learning outcomes of the Ethnic and Cultural Diversity material of grade IV A students who were taught using Kahoot learning media were better than without using Kahoot media in learning on Ethnic and Cultural Diversity material.
A Rare Diagnostic Challenge of Retroperitoneal Unicentric Castleman Disease.
Authors: Daghistani Ghaida 
Published: February 2025

1. Brief medical history.

48-year-old lady post-menopausal lady, medically free, presented to the hospital with fatigue over the last
8 months, she recently felt a mass in her abdomen. An ultrasound of the abdomen was performed and showed a soft tissue mass in the left hemiabdomen

2. Diagnostic hypothesis.

When formulating a differential diagnosis for a soft tissue mass in the retroperitoneal space, it is often helpful to
determine first, by radiographic examination, whether the enlargement originates primarily in retroperitoneal, organ, lymph node or vascular. Hence, an enhanced computed tomography (CT) scan was ordered.

3. Radiological findings with clinical outcome.

A CT performed after the administration of intravenous contrast material showed a large heterogenous left retroperitoneal soft tissue mass with central area of low attenuation in keeping with necrosis and a few punctate calcifications.

Borderline enlarged mesenteric, and para-aortic lymph nodes reaching up to 1 cm in short axis are also noted.

4. Differential diagnosis.

The differential diagnosis of a retroperitoneal lesion is broad and can include benign and neoplastic causes. Benign causes such as infection lymphadenopathy or abscess or benign neoplasm such as ganglioneuroma, angiomyolipoma, retroperitoneal fibrosis and hemangioma. Malignant neoplasm such as liposarcoma,
leiomyosarcoma and lymphoma.

Uncommon tumors of the retroperitoneal space include castleman disease, malignant peripheral nerve sheath tumor, clear cell sarcoma and ewing sarcoma among others. Distinguishing these processes is essentially impossible with imaging criteria alone, and ultimately a diagnosis based on histopathologic findings is essential.

5. Outcome, with definitive pathological diagnosis.

Based on radiology finding the pathway was leading toward retroperitoneal liposarcoma. The patient subsequently underwent surgical excision of the mass and the surgical specimen was sent to the pathology department.

Retroperitoneal microscopic mass examination showed Atretic germinal centers traversed by sclerotic penetrating vessels and hyalinization - lollipop follicles

On the basis of the histopathologic features castleman diseases was diagnosed.
Het algemene bewijsbeslag: de Hoge Raad heeft gesproken
Authors: de Boer N. 
Published: February 2025

Het algemene bewijsbeslag: de Hoge Raad heeft gesproken
De auteur bespreekt in haar bijdrage naar aanleiding van de beantwoording door de Hoge Raad van de prejudiciële vragen die werden gesteld over de (on)mogelijkheid van het leggen van bewijsbeslag in niet-IE-zaken het fenomeen ‘bewijsbeslag’. Zij schetst hierbij kort de voorgeschiedenis van de aan de Hoge Raad gestelde prejudiciële vragen. Vervolgens worden de door de Hoge Raad gegeven antwoorden besproken, waarbij de auteur vanuit de praktijk beschouwd af en toe een kritische aantekening plaatst. De auteur spreekt in haar conclusie de hoop uit dat de wetgever tot wetgeving zal overgaan.
Uitleg van uiterste wilsbeschikkingen
Authors: Luimes A.J. 
Published: February 2025

Uitleg van uiterste wilsbeschikkingen
Het onderhavige artikel gaat over de uitleg van uiterste wilsbeschikkingen. Aan de hand van enkele recente uitspraken wordt inzicht geboden in de vraag wanneer een zuiver taalkundige uitleg van een uiterste wilsbeschikking wel of niet volstaat.
Project-based Augmented Reality (PjBAR): Evaluation for Vocational Education Effectiveness
Authors: Muslim Muslim , Ambiyar Ambiyar , Karudin Arwizet Karudin , Hazwan Ruslan Muhammad Syafiq , Kuo Hsu-Chan , Putra Yanto Doni Tri 
Published: February 2025

Introduction: The Industrial Revolution 4.0 requires vocational education to adopt innovative learning approaches that integrate advanced technology with real work practices. This study aims to analyze the effectiveness of the Project-based Augmented Reality (PjBAR) model in improving the quality of learning in vocational education. Methods: Data were collected through a trial implementation of the PjBAR model compared to direct instruction. The effectiveness of the model was analyzed using effect size to determine how much influence the PjBAR model had on learning outcomes. Results: This study revealed a significant difference between the PjBAR model class and the direct instruction method. The average learning outcomes of the PjBAR class were superior to those of the direct instruction class. Effect size analysis indicated that the PjBAR model had a strong impact on improving student learning outcomes. Conclusions: This model not only improves learning outcomes and the quality of education but is also able to provide a more interesting learning experience through the integration of augmented reality technology, making it relevant to meet the needs of 21st-century learning.
Quality of life in the adult bigger than a community
Authors: Remis Lorenzo Deborah Margarita , Díaz Pita Gicela , Hernández Ávila Frank , Dot Pérez Licet del Carmen , González Horta Anisleidi 
Published: February 2025

Introduction: the populational aging in a challenge for the modern societies and the quality of a person's life is of the interaction of multiple factors. Objective: to evaluate the quality of life in the bigger adult belonging to the medical clinic 129 of the Policlínico Siblings Cruz of the municipality Pinegrove of the River in the period of January of the 2021 to July 2023. Method: he/she was carried out an intervention study, the universe it was constituted by bigger 229 patients adults, a sample was not selected bigger probabilística of 96 adults that fulfilled the inclusion approaches, theoretical, empiric methods they were used and of the descriptive statistic, given in absolute and relative numbers. Results: a perception of the quality of half life of 64,58% prevailed in the age group from 60 to 69 years, the feminine sex with 54,16%, the married bigger adults for 56,25%, the level of school of primary without finishing and secondary finished with 27,08%; the dimensions of the quality of life in the biggest adult were high after the intervention, with the educational intervention a level of knowledge is evaluated about the perception of quality of the appropriate bigger adults' life with 81,25% Conclusions: The perception of the dimensions of quality of the biggest adults' life, after the intervention was high and the level of knowledge about the perception of the quality of life was evaluated of appropriate.
Clinical-epidemiological factors associated with mortality in patients diagnosed with acute heart failure
Authors: Turro Caró Eloy , Mesa Valiente Rita María , Turro Mesa Lucia Nivia , Montes de Oca Carmenaty Margarita 
Published: February 2025

Introduction: acute heart failure is a high mortality event in the population that may depend on various clinical and epidemiological factors.Objective: determine the clinical-epidemiological factors associated with the mortality of patients diagnosed with acute heart failure.Method: a cross-sectional descriptive study was carried out with the purpose of determining the clinical-epidemiological factors associated with the mortality of patients with a diagnosis of acute heart failure, admitted to the cardiology ward of the “Saturnino Lora Torres” Provincial Hospital of Santiago de Cuba in the period from January 2021 to December 2023. The universe consisted of 454 patients, from whom a sample was taken (n=70) and divided into two groups: deceased and alive. The Chi Square value (x2) was estimated to determine the statistical association. Results: clinical-epidemiological factors associated with mortality in patients diagnosed with acute heart failure include age over 80 years, male sex, history of arterial hypertension and diabetes mellitus, presentation as acute coronary syndrome, as well as less than 3 days of hospital stay.Conclusions: the clinical-epidemiological factors of the patients studied were very similar to those described in the bibliography consulted and despite the multiple protocols and guidelines implemented, in-hospital mortality remains high.
Isolasi dan Uji Aktivitas Antibakteri Jamur Tanah dari Kandang Ternak di Tamanan, Banguntapan
Authors: Rahmawati Iin , Ismiyati Nur , Irianto Iramie Duma Kencana 
Published: February 2025

Infeksi merupakan penyakit menular yang paling mematikan. Infeksi yang tinggi menyebabkan penggunaan antibiotik semakin tinggi. Kasus infeksi oleh bakteri menjadi sepuluh besar kasus yang mengakibatkan kematian. Oleh karena itu, dibutuhkan agen bakteri yang potensial untuk mengatasi masalah infeksi. Tujuan penelitian ini untuk mengetahui aktivitas antibakteri jamur hasil isolasi dari kandang ternak di Tamanan, Banguntapan terhadap beberapa jenis bakteri.
Isolasi jamur dilakukan dengan pengenceran menggunakan media PDA, selanjutnya dilakukan pemurnian isolat dan uji aktivitas antibakterinya. Metode yang digunakan dalam penentuan aktivitas antibakteri pada penelitian ini yaitu metode difusi cakram yang akan diujikan terhadap bakteri Staphylococcus aureus, Streptococcus mutans, Escherichia coli, dan Bacilus subtillis. Hasil mikroskopis dan makroskopis isolat jamur diolah secara deskriptif. Hasil uji aktivitas antibakteri dibandingkan antar perlakuan secara statistik menggunakan uji Kruskal-Wallis.
Hasil penelitian menunjukkan ketiga isolat tidak memiliki daya hambat terhadap bakteri S.aureus dan E.coli. Isolat C1 (isolat jamur tanah kandang ternak sapi) dan isolat C4 (isolat jamur tanah kandang ternak sapi) masuk dalam kategori kuat dalam menghambat S.mutans dan B.subtillis. Diameter zona hambat yang dihasilkan Isolat C1 (isolat jamur tanah kandang ternak sapi) sebesar 11,67 mm dan Isolat C4 (isolat jamur tanah kandang ternak sapi) sebesar 10,67 mm terhadap S.mutans. Zona hambat yang dihasilkan Isolat C1 (isolat jamur tanah kandang ternak sapi) sebesar 11,17 mm dan Isolat C2 (isolat jamur tanah kandang ternak sapi) sebesar 7,17 mm terhadap B.subtillis.
Evaluation of Percentage of Damaged Drugs at Gondomanan Primary Health Center in Yogyakarta
Authors: Titami Arina , Andriani Yuni , Saputra Doni 
Published: February 2025

Background: The proper storage and distribution of drugs is very important to ensure the effects of drugs in the body and all drugs should be stored in the right storage place. Improper drug storage can cause damage to drugs that can endanger patients and health services themselves.
Objective: This study aims to evaluate the drug storage process, specifically the percentage of damaged drugs, at the Gondomanan Primary Health Center in Yogyakarta.
Method: The research was conducted using a descriptive observational approach with a cross-sectional design. Data were collected using a checklist referring to Peraturan Menteri Kesehatan Republik Indonesia Nomor 74 Tahun 2016 and Petunjuk Teknis Standar Pelayanan Kefarmasian di Puskesmas Tahun 2019.
Result: The percentage of damaged drugs at the Gondomanan Primary Health Center in Yogyakarta is 0%.
Conclusion: The percentage of damaged drugs at the Gondomanan Primary Health Center in Yogyakarta is by standards based on Peraturan Pemerintah Kesehatan Republik Indonesia Nomor 74 Tahun 2016 and Petunjuk Teknis Standar Pelayanan Kefarmasian di Puskesmas Tahun 2019.
Safety Profile and Antiulcerogenic Activities of Cordia Vignei Hutch & Dalziel (Boraginaceae) Leaf Extract Against Chronic DSS-Induced Colitis in C57BL/6 Mice
Authors: Owusu George , Antwi-Adjei Meshack , Aboagye Benjamin , Antwi-Adjei Roberta , Abrokwah Francis Kwame , Adu-Asamoah William 
Published: February 2025

Cordia vignei plant is used in folkloric medicine to treat numerous inflammatory disorders. The inflammatory bowel disease incidence rate is steadily increasing in developing countries and is mostly characterized by recurrent inflammation along with major problems. The current study aimed to establish the acute oral safety of Cordia vignei leaf extract and evaluated its antiulcerogenic activities in a DSS-induced colitis model in mice. The phytomedicinal efficacy of CVE (30, 100, and 300 mg/kg, p.o) on colitis was assessed by inducing 5% () dextran sodium sulfate [MW= 50 kD] in mice. Clinical parameters were studied, including body and organ weights, macroscopic and histological examinations, hematological and biochemical analyses, and antioxidant activity. We showed that Cordia vignei extract significantly improved body and colon weights restored hematological indicators (P<0.05), and reduced disease activity index scores (P<0.05). Additionally, Cordia vignei extract inhibited histoarchectural alterations in the colons and inhibited oxidative damage to the colon tissues (P<0.05). Furthermore, Cordia vignei extract was found to be acutely safe. We, therefore, conclude that Cordia vignei extract exhibited an ameliorative effect against dextran sodium sulphate-induced colitis in mice.
Penerapan Pembelajaran Qurma (Qur’an Dan Makna) untuk Meningkatkan Keterampilan Berbicara Siswa di MIN 3 Labuhanbatu
Authors: Sifa Khairunnisa Ritonga  , Abdul Sattar Daulay  , Nursyaidah Nursyaidah  
Published: February 2025

The background of this research is the condition where students‘ speaking skills are low in class IV A Madrasah Ibtidaiyah Negeri 3 Labuhanbatu. Based on observation data, students’ speaking skills in class IV A Madrasah Ibtidaiyah Negeri 3 Labuhanbatu are below 25%. Therefore, qurma learning is one of the solutions to improve students' speaking skills. Qurma learning is a process of interaction between students, teachers, and learning resources directly in a learning environment, where this learning process teaches students to be able to understand the meaning or content of the Qur'an by getting to know the stories that are in it. Speaking skills play a very important role in elementary school. Speaking skills are mechanistic, meaning that speaking skills are acquired through a process of continuous practice. So, as much practice as possible will make students skilled in speaking. Fostering speaking skills in students can be done through the qurma learning process (qur'an and meaning). Qurma learning is done by familiarising and training students to be skilled in telling stories related to the meaning of the Qur'an. The purpose of this study is to determine whether there is an improvement in students' speaking skills by using qurma learning in class IV A Madrasah Ibtidaiyah Negeri 3 Labuhanbatu. This research is a Classroom Action Research (PTK) using the Kurt Lewin model which contains the stages of planning, action, observation, and reflection. The data collection instruments used in this study were observation, interviews, documentation and tests. The results obtained by the researcher show that the application of qurma learning (qur'an and meaning) at Madrasah Ibtidaiyah Negeri 3 Labuhanbatu has increased from pre-cycle 25% or around 7 students who passed to 83% or 23 students who passed at the end of the meeting with the focus of habituation carried out such as telling the meaning contained in the Qur'an. Aiming for students to be able to convey with their own language orally or in writing. The implementation of qurma learning includes planning, implementation and evaluation of learning. The growth of speaking skills in students through qurma learning is characterised by the selection of words that are easy to understand, intonation placement, fluency, accuracy of speech and self-confidence.
Upaya Meningkatkan Minat Belajar Peserta Didik pada Materi Pengukuran Berbantuan Virtual Laboratorium OLABS pada Fase E SMAS Islam Darunnajah Sumenep
Authors: Herman Jufri Andi  , Analiatus Shofiyah  , Siska Siska  , Syaiful Bahri  , Moh Syamsul  
Published: February 2025

This research targets to increase college students' interest in studying physics with the help of OLABS media or virtual, the technique used is school room action research (PTK). Which entails cycles with meeting periods in every cycle. The difficulty of this study is elegance X college students with a complete of 15 college students. The records series method turned into accomplished using questionnaires and observations. based totally at the research that has been carried out in the pre-cycle degree, the average percentage of students' hobby in mastering physics became obtained through 60%, the "low class" in the first cycle turned into obtained by way of the average percent of students' interest in getting to know physics of seventy five%, the "medium category" within the 2nd cycle become received by using the average percent of students' interest in gaining knowledge of physics of 89% "high category". This indicates an boom in college students' interest in mastering physics from pre-cycle to cycle I by means of 15% and an boom from cycle I to cycle II by means of 14%. based totally on the analysis of pre-cycle information, cycle I and cycle II received an average increase inside the typical percent of physics getting to know interest through 29% so that it may be concluded that through OLABS media or virtual practicum can boom students' hobby in studying physics.