bluuebunny/crossref_metadata_2025_split huggingface dataset:
Productivity costs of schizophrenia spectrum and other psychotic disorders by friction cost and human capital methods: The Northern Finland Birth Cohort 1966
Authors: Majuri Tuomas , Nerg Iiro , Huikari Sanna , Rissanen Ina , Jääskeläinen Erika , Miettunen Jouko , Korhonen Marko 
Published: March 2024

Abstract
Purpose
Psychotic disorders are associated with substantial productivity costs; however no previous studies have compared these between schizophrenia spectrum (SSD) and other psychotic disorders (OP). The human capital method (HCM) and the friction cost method (FCM) are the two most common approaches to assess productivity costs. The HCM focuses on employees’ perspectives on the costs, whereas the FCM demonstrates employers’ perspectives. Studies comparing these methods when estimating the productivity costs of psychoses are lacking.

Methods
Utilizing the Northern Finland Birth Cohort 1966 with linkages to national registers, we compared the adjusted productivity costs of SSD (n = 216) and OP (n = 217). The productivity costs were estimated from ages 18 to 53 including projections to statutory retirement age using the FCM and HCM.

Results
When estimated via the HCM, productivity losses were higher for SSD (€193,940) than for OP (€163,080). However, when assessed using the FCM, costs were significantly lower for SSD (€2,720) than for OP (€4,430). Productivity costs varied by sex and various clinical and occupational factors.

Conclusion
This study highlights how productivity costs vary by psychosis diagnosis. These differences should be noted when planning interventions. The low FCM estimates indicate the need of interventions before or during the early phases of psychoses. From a societal perspective, interventions are needed, particularly for those with highest HCM productivity losses, such as males with SSD. Besides psychiatric services, the roles of social services, employment agencies and occupational health care should be considered when helping individuals with psychoses to working life.
Hyperspectral image dynamic range reconstruction using deep neural network-based denoising methods
Authors: Cheplanov Loran , Avidan Shai , Bonfil David J. , Klapp Iftach 
Published: March 2024

AbstractHyperspectral (HS) measurement is among the most useful tools in agriculture for early disease detection. However, the cost of HS cameras that can perform the desired detection tasks is prohibitive-typically fifty thousand to hundreds of thousands of dollars. In a previous study at the Agricultural Research Organization’s Volcani Institute (Israel), a low-cost, high-performing HS system was developed which included a point spectrometer and optical components. Its main disadvantage was long shooting time for each image. Shooting time strongly depends on the predetermined integration time of the point spectrometer. While essential for performing monitoring tasks in a reasonable time, shortening integration time from a typical value in the range of 200 ms to the 10 ms range results in deterioration of the dynamic range of the captured scene. In this work, we suggest correcting this by learning the transformation from data measured with short integration time to that measured with long integration time. Reduction of the dynamic range and consequent low SNR were successfully overcome using three developed deep neural networks models based on a denoising auto-encoder, DnCNN and LambdaNetworks architectures as a backbone. The best model was based on DnCNN using a combined loss function of $$\ell _{2}$$

ℓ
2

and Kullback–Leibler divergence on images with 20 consecutive channels. The full spectrum of the model achieved a mean PSNR of 30.61 and mean SSIM of 0.9, showing total improvement relatively to the 10 ms measurements’ mean PSNR and mean SSIM values by 60.43% and 94.51%, respectively.
Quorum quenching effect of cyclodextrins on the pyocyanin and pyoverdine production of Pseudomonas aeruginosa
Authors: Fekete-Kertész Ildikó , Berkl Zsófia , Buda Kata , Fenyvesi Éva , Szente Lajos , Molnár Mónika 
Published: March 2024

Abstract
Various virulence determinants in Pseudomonas aeruginosa are regulated by the quorum sensing (QS) network producing and releasing signalling molecules. Two of these virulence determinants are the pyocyanin and pyoverdine, which interfere with multiple cellular functions during infection. The application of QS-inhibiting agents, such as cyclodextrins (CDs), appears to be a promising approach. Further to method development, this research tested in large-volume test systems the effect of α- and β-CD (ACD, BCD) at 1, 5, and 10 mM concentrations on the production of pyocyanin in the P. aeruginosa model system. The concentration and time-dependent quorum quenching effect of native CDs and their derivatives on pyoverdine production was tested in a small-volume high-throughput system. In the large-volume system, both ACD and BCD significantly inhibited pyocyanin production, but ACD to a greater extent. 10 mM ACD resulted in 58% inhibition, while BCD only ~40%. Similarly, ACD was more effective in the inhibition of pyoverdine production; nevertheless, the results of RMANOVA demonstrated the significant efficiency of both ACD and BCD, as well as their derivatives. Both the contact time and the cyclodextrin treatments significantly influenced pyoverdine production. In this case, the inhibitory effect of ACD after 48 h at 12.5 mM was 57%, while the inhibitory effect of BCD and its derivatives was lower than 40%. The high-level significant inhibition of both pyocyanin and pyoverdine production by ACD was detectable. Consequently, the potential value of CDs as QS inhibitors and the antivirulence strategy should be considered.

Keypoints
• Applicability of a simplified method for quantification of pyocyanin production was demonstrated.
• The cyclodextrins significantly affected the pyocyanin and pyoverdine production.
• The native ACD exhibited the highest attenuation in pyoverdine production.
Revising Alpine summer temperatures since 881 CE
Authors: Kuhl Eileen , Esper Jan , Schneider Lea , Trouet Valerie , Kunz Marcel , Klippel Lara , Büntgen Ulf , Hartl Claudia 
Published: March 2024

AbstractEurope experienced severe heat waves during the last decade, which impacted ecological and societal systems and are likely to increase under projected global warming. A better understanding of pre-industrial warm-season changes is needed to contextualize these recent trends and extremes. Here, we introduce a network of 352 living and relict larch trees (Larix decidua Mill.) from the Matter and Simplon valleys in the Swiss Alps to develop a maximum latewood density (MXD) chronology calibrating at r = 0.8 (p > 0.05, 1901–2017 CE) against May–August temperatures over Western Europe. Machine learning is applied to identify historical wood samples aligning with growth characteristics of sites from elevations above 1900 m asl to extend the modern part of the chronology back to 881 CE. The new Alpine record reveals warmer conditions in the tenth century, followed by an extended cold period during the late Medieval times, a less-pronounced Little Ice Age culminating in the 1810s, and prolonged anthropogenic warming until present. The Samalas eruption likely triggered the coldest reconstructed summer in Western Europe in 1258 CE (-2.32 °C), which is in line with a recently published MXD-based reconstruction from the Spanish Pyrenees. Whereas the new Alpine reconstruction is potentially constrained in the lowest frequency, centennial timescale domain, it overcomes variance biases in existing state-of-the-art reconstructions and sets a new standard in site-control of historical samples and calibration/ verification statistics.
Role of pH-sensing receptors in colitis
Authors: Hausmann Martin , Seuwen Klaus , de Vallière Cheryl , Busch Moana , Ruiz Pedro A. , Rogler Gerhard 
Published: March 2024

AbstractLow pH in the gut is associated with severe inflammation, fibrosis, and colorectal cancer (CRC) and is a hallmark of active inflammatory bowel disease (IBD). Subsequently, pH-sensing mechanisms are of interest for the understanding of IBD pathophysiology. Tissue hypoxia and acidosis—two contributing factors to disease pathophysiology—are linked to IBD, and understanding their interplay is highly relevant for the development of new therapeutic options. One member of the proton-sensing G protein-coupled receptor (GPCR) family, GPR65 (T-cell death-associated gene 8, TDAG8), was identified as a susceptibility gene for IBD in a large genome-wide association study. In response to acidic extracellular pH, GPR65 induces an anti-inflammatory response, whereas the two other proton-sensing receptors, GPR4 and GPR68 (ovarian cancer G protein-coupled receptor 1, OGR1), mediate pro-inflammatory responses. Here, we review the current knowledge on the role of these proton-sensing receptors in IBD and IBD-associated fibrosis and cancer, as well as colitis-associated cancer (CAC). We also describe emerging small molecule modulators of these receptors as therapeutic opportunities for the treatment of IBD.
Identification roles of NFE2L3 in digestive system cancers
Authors: Li Fan , Wen Zhili 
Published: March 2024

Abstract
Background
Morbidity and mortality rates of Digestive System Cancers (DSC) continue to pose human lives and health. Nuclear factor erythroid 2-like protein 3 (NFE2L3) is aberrantly expressed in DSC. This study aimed to explore the clinical value and underlying mechanisms of NFE2L3 as a novel biomarker in DSC.

Methods
We utilized data from databases and clinical gastric cancer specimens to validate the aberrant expression level of NFE2L3 and further assessed the clinical value of NFE2L3. To investigate the potential molecular mechanism of NFE2L3, we analyzed the correlation of NFE2L3 with immune molecular mechanisms, constructed PPI network, performed GO analysis and KEGG analysis, and finally explored the biological function of NFE2L3 in gastric cancer cells.

Results
NFE2L3 expression is up-regulated in DSC and has both prognostic and diagnostic value. NFE2L3 correlates with various immune mechanisms, PPI network suggests proteins interacting with NFE2L3, GSEA analysis suggests potential molecular mechanisms for NFE2L3 to play a role in cancer promotion, and in vitro cellular experiments also confirmed the effect of NFE2L3 on the biological function of gastric cancer cells.

Conclusion
Our study confirms the aberrant expression and molecular mechanisms of NFE2L3 in DSC, indicating that NFE2L3 could serve as a novel biomarker for diagnosis and prognosis of DSC.
Analyzing the associations between tertiary lymphoid structures and postoperative prognosis, along with immunotherapy response in gastric cancer: findings from pooled cohort studies
Authors: Peng Haoxin , Wu Xiangrong , Zhang Cheng , Liang Yueting , Cheng Siyuan , Zhang Honglang , Shen Lin , Chen Yang 
Published: March 2024

Abstract
Background
The clinical significance of tertiary lymphoid structure (TLS) in gastric cancer (GC) was uncertain.

Methods
A systematic search was performed in public databases for eligible studies as of April 2, 2023. Meta-analyses were performed to interrogate the associations between TLS levels and prognosis and immunotherapy response of GC. Bioinformatic analyses based on the nine-gene signature of TLS were further conducted to capture the biological underpinnings.

Results
Eleven studies containing 4224 GC cases were enrolled in the meta-analysis. TLS levels positively correlated with smaller tumor size, earlier T stage and N stage. Moreover, higher TLS levels were detected in diffuse and mix subtypes of GC (P < 0.001). Higher TLS levels strongly predicted favorable postoperative overall survival of GC, with HR of 0.36 (95%CI 0.26–0.50, P < 0.001) and 0.55 (95%CI 0.45–0.68, P < 0.001) of univariate and multivariate Cox analysis, respectively. Higher TLS levels were also in favor of the treatment response of anti-PD-1 inhibitors as later-line therapy of GC. TLS levels positively correlated with immune effector cells infiltration, diversity and richness of T cell receptor and B cell receptor repertoire, immune checkpoint genes expression, and immune-related genes mutation of GC in the TCGA-STAD cohort, representing higher immunogenicity and immunoactivity. Moreover, moderate accuracy of TLS levels in predicting benefit from anti-PD-1 inhibitors in the PRJEB25780 cohort was also validated (AUC 0.758, 95%CI 0.583–0.933), higher than the microsatellite instability-score and Epstein-Barr virus status.

Conclusions
TLS levels demonstrated potential in predicting the postoperative prognosis and immunotherapy response of GC.
Entanglement in Few-Nucleon Scattering Events
Authors: Kirchner Tanja , Elkamhawy Wael , Hammer Hans-Werner 
Published: March 2024

AbstractWe investigate the spin entanglement in few-nucleon scattering processes involving nucleons and deuterons. For this purpose, we consider the entanglement power introduced by Beane et al. We analyze different entanglement entropies as a basis to define the entanglement power of the strong interaction and calculate the corresponding entanglement powers for proton–neutron, neutron–deuteron, proton–deuteron, and deuteron–deuteron scattering. For the latter two processes, we also take into account the modification from the Coulomb interaction. In contrast to proton–neutron scattering, no universal low-energy features are evident in the spin entanglement in neutron–deuteron, proton–deuteron, and deuteron–deuteron scattering.
Evaluating risk factors and complications in mandibular ramus block grafting: a retrospective cohort study
Authors: Bayram Ferit , Göçmen Gökhan , Özkan Yaşar 
Published: March 2024

Abstract
Objectives
This retrospective cohort study aimed to identify the complications and risk factors associated with alveolar grafting using autologous mandibular ramus grafts, guided by the research question: What are the complications encountered in patients undergoing alveolar bone grafting using autologous mandibular ramus block and what are the risk factors associated with the development of these complications?

Materials and methods
The study included 70 patients who underwent alveolar crest augmentation with autologous mandibular ramus block grafting. Intraoperative, early postoperative, and late postoperative complications were analyzed, as were various risk factors.

Results
The results showed that the majority of patients had successful outcomes with minimal complications. Sex was found to significantly influence the visibility of the inferior alveolar nerve (IAN). Early postoperative complications were associated with IAN visibility and the use of a single screw for graft fixation. Late postoperative complications were significantly associated with the presence of infection.

Conclusion
The findings emphasize the importance of careful surgical techniques, infection prevention, and patient selection in minimizing complications.

Clinical relevance
This article may contribute to clinicians’ and so patients’ understanding of potential risk factors associated with over all ramus block grafting procedure. Based on this information, clinicians can also improve their ability to manage risk factors and associated complications and compare ramus block grafting with other alternatives to determine the best treatment approach for that particular patient.
Molecular monitoring of viral infections in immunocompromised patients in a large university hospital in Italy: reflections after thirteen years of real-life activity
Authors: Cinti Lilia , Roberto Piergiorgio , Rossi Matteo , Napoli Anna , Russo Gianluca , Iori Anna Paola , Gentile Giuseppe , Augurusa Maria , Girmenia Corrado , Antonelli Guido , Gaeta Aurelia 
Published: March 2024

Abstract
Purpose
This study aimed to investigate the prevalence and viral reactivations of clinical interest in the immunocompromised patient with particular focus on hematologic and solid organ transplant recipients.

Methods
Molecular screening data of CMV, EBV, JCV and BKV from 2011 to 2023 were analyzed. This extensive time span allowed the access to more than 100,000 samples from over 20,000 patients treated at Policlinico Umberto I. It was possible to temporally investigate patient attendance patterns, average age distribution, seasonality of infections, and positivity rates of the analyzed viruses.

Results
Between 2019 and 2022 a significant reduction in organ transplants performed and in the positive molecular detection of EBV, JCV and BKV was observed. Additionally, there has been a noteworthy decrease in CMV reactivations, with a reduction of up to 50% starting in 2019. A remarkable reduction of 39% in the rate of CMV viral reactivation has been also achieved in SOT between 2016 and 2023.

Conclusion
The years following 2019 were profoundly impacted by the COVID-19 pandemic era. This period resulted in a substantial reduction in healthcare services and hospital visits. Furthermore, the introduction of the drug Letermovir in Italy in 2019 demonstrated remarkable efficacy, evidenced by a reduction in CMV reactivations. Additionally, the adoption of a novel clinical approach centered on personalized therapy facilitated improved management of immunocompromised patients.
Use of Cranberry Bush (Viburnum opulus L.) Fruit Pomace as a Renewable Substrate for Biobutanol Production by Clostridium beijerinckii in the Presence of Sodium Dithionite
Authors: Çelik Mariye Nur , Tekin Nazlıhan , Karatay Sevgi Ertuğrul , Dönmez Gönül 
Published: March 2024

AbstractThe present study aims to evaluate the use of cranberry bush fruit pomace (CBFP) (Viburnum opulus L.), which has recently become popular raw material, as a substrate in the presence of a reducing agent to increase biobutanol production by Clostridium beijerinckii DSMZ 6422. For this purpose, some factors were optimized, including the pretreatment, initial concentration of CBFP (5–20%), different types of reducing agents (ascorbic acid, L-cysteine, sodium dithionite and sodium sulfite), different concentrations of sodium dithionite (2.5–15 mM), inoculum concentration (5%, 10%, and 20%), and fermentation time (24–96 h). The maximum biobutanol, total ABE, biobutanol yield, and biobutanol productivity were 9.45 g/L, 12.08 g/L, 0.21 g/g, and 0.13 g/L/h in the medium containing enzymatically hydrolyzed 10% CBFP, 10 mM sodium dithionite, and 20% inoculum at the end of 72 h, respectively. These findings demonstrate that CBFP can be considered as a sustainable, economical, and viable substrate on biobutanol production for the first time in the literature.
Transnational juku: Japanese shadow education institutions in Hong Kong, Beijing, and Shanghai
Authors: Kato Mako , Kobakhidze M. Nutsa 
Published: March 2024

AbstractJapan has a longstanding history of shadow education, which has evolved, transformed, and extended beyond its borders. Japanese shadow education institutions, known as juku, have expanded worldwide, including in Asia, the US, and Europe, offering offline and online tutoring services mainly for Japanese expatriates. This study examines the role and features of juku, specifically in Beijing, Hong Kong, and Shanghai. It identifies 20 different juku, analyzes their types, and explains a different type of juku, the “Japanese cultural supplementary school,” that caters to expatriate parents aiming to nurture Japanese culture and traditions in their children. Although the Japanese juku phenomenon has previously attracted the attention of scholars, there is a gap in the literature when it comes to transnational juku and its operation outside Japan. This paper contributes to informing scholars, policymakers, and the public on the transnational movement of shadow education as a global phenomenon.
Biochemical and molecular analyses of insecticide resistance in greenhouse populations of Bemisia tabaci (Hemiptera: Aleyrodidae) in Türkiye
Authors: Erdogan Cem , Toprak Umut , Gurkan M. Oktay 
Published: March 2024

AbstractThe sweet potato/cotton whitefly Bemisia tabaci (Gennadius) (Hemiptera: Aleyrodidae) is one of the most destructive vegetable pests in greenhouses in Türkiye. While the preferred method of control primarily relies on insecticides such as neonicotinoids, organophosphates and pyrethroids, their intensive use has caused whiteflies to rapidly become resistant. Samples were collected from 13 Turkish B. tabaci greenhouse populations. Bioassays from the Marmara Region identified as high as a 53-fold increase in resistance to chlorpyrifos-ethyl, a 303-fold increase to imidacloprid and a 282-fold increase to acetamiprid. Bioassays in the Central Anatolia Region reported a 76-fold increase in resistance to deltamethrin and—15-fold increase to thiamethoxam. Most of the populations showed cross-resistance for neonicotinoids. All collected B. tabaci populations were determined to be MEAM 1 (also referred to as biotype B) for diagnostic band E0.14. The E0.14 esterase variant that helps to diagnose biotype B insects was found in all individuals from field populations. Almost all populations showed higher non-specific esterase, glutathione-S-transferase (GST) and monooxygenase activity when compared to susceptible SUD-S population. AChE insensitivity assays for individual B. tabaci suggest a target-site modification as a mechanism of resistance to chlorpyrifos-ethyl. This is the first report of AChE variants identified based on their sensitivities to chlorpyrifos ethyl-oxon and pirimicarb in Turkish B. tabaci populations. Fixed ace mutations in the target-site of organophosphates and pyrethroids were identified in six populations. Resistance to organophosphates and neonicotinoids were at least partially related to both ace mutations and insensitive AChE and monooxygenase activities, respectively. The results will help develop effective resistance management programs of B. tabaci in Türkiye.
Graphical Abstract
Upper limit estimate to wellhead flowing pressure and applicable gas production for a downhole throttling technique in high-pressure–high-temperature gas wells
Authors: Wang Faqing , Qin Deyou , Zhang Bao , He Jianfeng , Wang Fangzhi , Zhong Ting , Zhang Zhida 
Published: March 2024

AbstractIn recent years, China has explored and exploited several high-pressure deep gas fields. Normally, high-pressure gas wells are gathered and processed through multichoke manifolds on well sites, creating hazards such as high wellhead flowing pressure (Pt) and high risk for on-site operation personnel. Moreover, downhole chokes have been used in place of surface chokes. In doing this, the Joule–Thomson (JT) effect is geothermally regulated, alleviating the formation of hydrates in surface facilities. However, its applicability to high-pressure gas wells is less explored. In an effort to guide its use, the objective of this study is to set selection criteria in terms of the allowable wellhead Pt and gas flow rate. First, isenthalpic lines are separately estimated for dry gas and high liquid hydrocarbon (LHC) content gas condensate at various inlet temperatures with the use of commercial software. Next, by analysis of the resulting isenthalpic curves, several results are obtained on the JT inversion curves and throttling process through a choke. Third, building on these insights, a method for projecting the maximum Pt is presented, leading to a value of 52.5 MPa. Finally, multiparameter models are separately run for two deep gas wells (8100 m and 5000 m), reinforcing the result of the pressure upper limit while maintaining a maximum daily gas production of 14 E4 m3. Both upper limits with a maximum Pt of 52.5 MPa and daily gas production of 14 E4 m3 are corroborated with field data records. These findings are vital to the selection of a viable high-pressure gas well for applying the downhole throttling technique.