bluuebunny/crossref_metadata_2025_split huggingface dataset:
Triterpenes and Flavonol Glucuronides from Oenothera cheiranthifolia.
Authors: Nakanishi Tsutomu , Inatomi Yuka , Murata Hiroko , Ishida Syun‐suke , Fujino Yuri , Miura Kanako , Yasuno Yoshito , Inada Akira , Lang Frank A. , Murata Jin 
Published: June 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Total Synthesis of Marine Bisindole Alkaloid (+)‐cis‐Dihydrohamacanthin B.
Authors: Higuchi Kazuhiro , Takei Ryousuke , Kouko Takashi , Kawasaki Tomomi 
Published: June 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Sequential Cross‐Metathesis/Cyclopropanation: Short Syntheses of (.+‐.)‐Cascarillic Acid and (.+‐.)‐Grenadamide.
Authors: Salim Hani , Piva Olivier 
Published: June 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Total Synthesis of (‐)‐12,13‐epi‐Obtusenyne.
Authors: Suzuki Toshio , Yoshino Nobuyuki , Uemura Toshiyuki , Hagiwara Hisahiro , Hoshi Takashi 
Published: June 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
High‐Density Storage of H2 in Microporous Crystalline Silica at Ambient Conditions.
Authors: van den Berg Annemieke W. C. , Pescarmona Paolo P. , Schoonman Joop , Jansen Jacobus C. 
Published: June 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Preparation of Molybdenum Oxide Thin Films by MOCVD.
Authors: Martinez Guerrero R. , Vargas Garcia J. R. , Santes V. , Gomez E. 
Published: June 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Infrared Spectroscopy of Transient Surface Species
Authors: Lamberti C. , Groppo E. , Spoto G. , Bordiga S. , Zecchina A. 
Published: June 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Enzyme‐Catalyzed Regioselective Synthesis of Sugar Esters and Related Compounds
Authors: Kennedy John F. , Kumar Harish , Panesar Parmjit S. , Marwaha Satwinder S. , Goyal Rita , Parmar Anupama , Kaur Sukhwinder 
Published: June 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
The Role of Secondary Interactions in the Asymmetric Palladium‐Catalyzed Hydrosilylation of Olefins with Monophosphane Ligands
Authors: Gibson Susan E. , Rudd Matthew 
Published: June 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Recent Progress on the Stereoselective Synthesis of Acyclic Quaternary α‐Amino Acids
Authors: Cativiela Carlos , Diaz‐de‐Villegas Maria D. 
Published: June 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
pH‐Responsive Multi‐PEGylated Dual Cationic Nanoparticles Enable Charge Modulations for Safe Gene Delivery
Authors: Xiong May P. , Bae Younsoo , Fukushima Shigeto , Forrest M. Laird , Nishiyama Nobuhiro , Kataoka Kazunori , Kwon Glen S. 
Published: June 2007

AbstractIn gene therapy, the cytotoxicity of many polycations is undesirable and has been attributed to nonspecific membrane destabilizing effects and intracellular polyplex‐mediated toxicity. To help prolong the pharmacokinetic profile of nonviral vehicles for gene delivery, the cationic surface charge of current systems is typically shielded through the conjugation of polyethylene glycol (PEG) chains to the particle surface. However, the design of an intelligent polycation with environment‐sensing charge modulations is essential to minimize cytotoxicity and enhance gene expression. We have designed a novel di‐cationic block copolymer, poly(aspartate‐hydrazide)‐block‐poly(L‐lysine), capable of pH‐mediated endosomal membrane disruption based on charge interactions, which has negligible toxicity elsewhere to the cell. The poly(L‐lysine) segment, with a high pKa value of ∼9.4, preferentially forms a poly‐ion complex with the negative phosphate groups of pDNA, whereas the pH‐responsive poly(aspartate‐hydrazide) segment, with the comparatively lower pKa ∼5.0, is characterized by a substantial fraction of unprotonated amino groups at physiological pH. As a consequence, complexation between such a polymer and pDNA leads to the formation of a two‐layered nanoparticle. In particular, the nanoparticle possesses an unprotonated pH‐responsive segment to serve as both a scaffold for acid‐labile linkages of various moieties such as aldehyde‐PEG and to transition from neutral to charged for disrupting endosomal membranes, and safely enhancing gene expression. Our system supports an endosomal escape mechanism based on charge interactions rather than the proton‐sponge effect, and may be an important step towards engineering new classes of intelligent nonviral vectors.
The usefulness of 18F‐fluorodeoxyglucose positron emission tomography (18F‐FDG‐PET) and a comparison of 18F‐FDG‐pet with 67gallium scintigraphy in the evaluation of lymphoma
Authors: Tsukamoto Norifumi , Kojima Masaru , Hasegawa Masatoshi , Oriuchi Noboru , Matsushima Takafumi , Yokohama Akihiko , Saitoh Takayuki , Handa Hiroshi , Endo Keigo , Murakami Hirokazu 
Published: June 2007

AbstractBACKGROUND.Although studies comparing conventional imaging modalities with 18F‐fluorodeoxyglucose positron emission tomography (18F‐FDG‐PET) for the detection of lymphoma and although the relations between 18F‐FDG‐PET and histologic types were reported previously, most studies were not systematic and involved relatively small numbers of patients.METHODS.Two hundred fifty‐five patients with lymphoma had their disease staged using 18F‐FDG‐PET, and 191 of those patients also were assessed using gallium‐67 scintigraphy (67Ga). Disease sites were identified on a site‐by‐site basis using computed tomography scans and/or magnetic resonance imaging. The results of these conventional imaging modalities were compared with the results from 8F‐FDG‐PET and 67Ga, and correlations between the imaging results and pathologic diagnoses were evaluated by using the World Health Organization classification system.RESULTS.Of 913 disease sites in 255 patients, 18F‐FDG‐PET identified >97% of disease sites of Hodgkin lymphoma (HL) and aggressive and highly aggressive non‐Hodgkin lymphoma. For indolent lymphoma, the detection rate of 18F‐FDG‐PET was 91% for follicular lymphoma (FL); 82% for extranodal marginal zone B‐cell lymphoma of mucosa‐associated lymphoid tissue, irrespective of plasmacytic differentiation; and approximately 50% for small lymphocytic lymphoma (SLL) and splenic marginal zone lymphoma (SMZL). The results from 67Ga were similar to those from 18F‐FDG‐PET for most histologic subtypes. However, the sensitivity of 67Ga was unexpectedly poor for FL, for mantle cell lymphoma (MCL), and for the nasal type of natural killer/T‐cell lymphoma (NK/T‐nasal), ranging from 30% to 38%.CONCLUSIONS.18F‐FDG‐PET was useful for all histologic subtypes of lymphoma other than SLL and SMZL. Compared with 67Ga, the authors strongly recommend the use of 18F‐FDG‐PET in patients with FL, MCL, and NK‐nasal. Cancer 2007. © 2007 American Cancer Society.
Racial disparities and socioeconomic status in association with survival in a large population‐based cohort of elderly patients with colon cancer
Authors: Du Xianglin L. , Fang Shenying , Vernon Sally W. , El‐Serag Hashem , Shih Y. Tina , Davila Jessica , Rasmus Monica L. 
Published: June 2007

AbstractBACKGROUND.To the authors' knowledge, few studies have addressed racial disparities in the survival of patients with colon cancer by adequately incorporating treatment and socioeconomic factors in addition to patient and tumor characteristics.METHODS.The authors studied a nationwide and population‐based, retrospective cohort of 18,492 men and women who were diagnosed with stage II or III colon cancer at age ≥65 years between 1992 and 1999. This cohort was identified from the Surveillance, Epidemiology, and End Results (SEER) cancer registries‐Medicare linked databases and included up to 11 years of follow‐up.RESULTS.A larger proportion (70%) of African‐American patients with colon cancer fell into the poorest quartiles of socioeconomic status compared with Caucasians (21%). Patients who lived in communities with the lowest socioeconomic level had 19% higher all‐cause mortality compared with patients who lived in communities with the highest socioeconomic status (hazards ratio [HR], 1.19; 95% confidence interval [95% CI], 1.13–1.26; P < .001 for trend). The risk of dying was reduced only slightly after controlling for race/ethnicity (HR, 1.17; 95% CI, 1.10–1.24). Compared with Caucasian patients with colon cancer, African‐American patients were 21% more likely to die after controlling for age, sex, comorbidity scores, tumor stage, and grade (HR, 1.21; 95% CI, 1.12–1.30). After also adjusting for definitive therapy and socioeconomic status, the HR of mortality was only marginally significantly higher in African Americans compared with Caucasians for all‐cause mortality (HR, 1.10; 95% CI, 1.02–1.19) and colon cancer‐specific mortality (HR, 1.16; 95% CI, 1.01–1.33).CONCLUSIONS.Lower socioeconomic status and lack of definitive treatment were associated strongly with decreased survival in both men and women with colon cancer. Racial disparities in survival were explained substantially by differences in socioeconomic status. Cancer 2007. © 2007 American Cancer Society.
Effects of presurgical exercise training on cardiorespiratory fitness among patients undergoing thoracic surgery for malignant lung lesions
Authors: Jones Lee W. , Peddle Carolyn J. , Eves Neil D. , Haykowsky Mark J. , Courneya Kerry S. , Mackey John R. , Joy Anil A. , Kumar Vikaash , Winton Timothy W. , Reiman Tony 
Published: June 2007

AbstractBACKGROUND.To determine the effects of preoperative exercise training on cardiorespiratory fitness in patients undergoing thoracic surgery for malignant lung lesions.METHODS.Using a single‐group design, 25 patients with suspected operable lung cancer were provided with structured exercise training until surgical resection. Exercise training consisted of 5 endurance cycle ergometry sessions per week at intensities varying from 60% to 100% of baseline peak oxygen consumption (VO2peak). Participants underwent cardiopulmonary exercise testing, 6‐minute walk (6MW), and pulmonary function testing at baseline, immediately before, and 30 days after surgical resection.RESULTS.Five patients were deemed ineligible before surgical resection and were removed from the analysis. Of the remaining 20 patients follow‐up assessments were obtained for 18 (90%) before resection and 13 (65%) patients postresection. The overall adherence rate was 72%. Intention‐to‐treat analysis indicated that mean VO2peak increased by 2.4 mL · kg−1 · min−1(95% confidence interval [CI], 1.0–3.8; P = .002) and 6MW distance increased 40m (95% CI, 16–64; P = .003) baseline to presurgery. Per protocol analyses indicated that patients who attended ≥80% of prescribed sessions increased VO2peak and 6MWD by 3.3 mL·kg−1·min−1 (95% CI, 1.1–5.4; P = .006) and 49 meters (95% CI, 12–85; P = .013), respectively. Exploratory analyses indicated that presurgical exercise capacity decreased postsurgery, but did not decrease beyond baseline values.CONCLUSIONS.Preoperative exercise training is a beneficial intervention to improve cardiorespiratory fitness in patients undergoing pulmonary resection. This benefit may have important implications for surgical outcome and postsurgical recovery in this population. Larger randomized controlled trials are warranted. Cancer 2007. © 2007 American Cancer Society.
Health‐related quality of life among patients cured by surgery for esophageal cancer
Authors: Lagergren Pernilla , Avery Kerry N. L. , Hughes Rachael , Barham C. Paul , Alderson Derek , Falk Stephen J. , Blazeby Jane M. 
Published: June 2007

AbstractBACKGROUND.Little is known regarding the long‐term, health‐related quality of life (HRQL) of survivors of esophagectomy for cancer.METHODS.Consecutive patients completed the validated European Organization for Research and Treatment of Cancer general quality‐of life‐questionnaire (QLQ‐C30) and the esophageal‐specific module (QLQ‐OES18) before surgery and regularly thereafter for at least 3 years. Mean scores with 95% confidence intervals were calculated. The Student t test for paired data was used to determine differences between baseline and 3‐year HRQL scores in which scores differed by ≥5 points.RESULTS.Of 90 patients who underwent surgery, 47 patients (52%) survived for ≥3 years. In this group, most aspects of HRQL recovered to preoperative levels by the 3‐year assessment, except that scores for physical function, breathlessness, diarrhea, and reflux were significantly worse than at baseline (P < .01). However, patients reported significantly better emotional function 3 years after surgery than before treatment (P = .0008).CONCLUSIONS.Even after 3 years, patients who underwent esophagectomy suffered persistent problems with physical function and specific symptoms. These findings may be used to inform patients of the long‐term consequences of surgery. Cancer 2007. © 2007 American Cancer Society.
Effect of trace metals on reactive crystallization of gypsum
Authors: Sayan Perviz , Titiz‐Sargut Sibel , Avcı Burcu 
Published: June 2007

AbstractThe effect of Fe2+, Fe3+, and Cr3+ ions on crystallization of calcium sulfate dihydrate (gypsum) produced by the reaction between calcium hydroxide suspension and sulphuric acid solution was investigated at 3.5 pH and 65°C in the absence and presence of 2500 ppm citric acid concentration. Crystal size distributions, filtration rates, and morphology of gypsum were determined and discussed as a function of ion concentration. Average particle size of gypsum was not affected significantly by the presence of Fe2+, Fe3+, and Cr3+ ions individually. Variation of gypsum morphology depending on ion concentration affected the filtration characteristics. The presence of Fe3+ or Cr3+ ions besides 2500 ppm citric acid influenced both average particle size and filtration characteristics. The effect of citric acid on gypsum morphology was suppressed at high Fe3+ and Cr3+ ion concentrations. The change of morphology is related to the complex formation between Fe3+ or Cr3+ ions and citric acid at high ion concentrations. (© 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Synthesis, spectral, thermal and NLO properties of N,N ‐Dimethyl anilinium picrate
Authors: Chandramohan A. , Bharathikannan R. , Kandhaswamy M. A. , Chandrasekaran J. , Renganathan R. , Kandavelu V. 
Published: June 2007

AbstractThe crystalline substance N,N ‐dimethyl anilinium picrate(DMAP) was synthesized and the single crystals of the title compound were grown by slow evaporation solution growth technique at room temperature. The crystalline nature of the material has been confirmed by powder X‐ray diffraction method. The elemental analysis data confirm the stoichiometry and hence the molecular formula of the synthesized material. The formation of the charge‐transfer complex has been confirmed by UV‐visible spectral data. The infrared and 1H NMR spectroscopic data indicate a charge transfer activity associated with a proton transfer from the acceptor to the donor followed by intermolecular hydrogen bonding. Thermal behavior and stability of crystal were studied using thermo gravimetric (TG) and differential thermal analyses (DTA) techniques. The second harmonic generation (SHG) of the material was confirmed using Nd: YAG laser. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Abdichtung von Mauerwerk gegen Bodenfeuchtigkeit und nicht stauendes Sickerwasser
Authors: Rast Ronald 
Published: June 2007

AbstractIm Auftrag der Deutschen Gesellschaft für Mauerwerksbau, Berlin, wurde im Jahr 2006 ein Merkblatt zur Abdichtung von erdberührtem Mauerwerk erarbeitet. Autor des Merkblattes ist Prof. Dr.‐Ing. R. Oswald vom AIBAU, Aachener Institut für Bauschadensforschung und angewandte Bauphysik GmbH. Im Heft 2/2006 der Zeitschrift Mauerwerk wurde bereits allgemein über das Merkblatt informiert. In diesem Beitrag wird speziell auf die Abdichtung von Mauerwerk gegen Bodenfeuchtigkeit und nicht stauendes Sickerwasser eingegangen.
Regelgerechte Ausführung von Kellerwänden aus Mauerwerk
Authors: Pohl Reiner 
Published: June 2007

AbstractDie meisten Keller in Deutschland werden gemauert. Sie lassen sich bei Verarbeitung leichter großformatiger Mauersteine per Hand oder bei Steinen mit höherem Verarbeitungsgewicht (hohe Rohdichte, Elemente) mit dem Versetzgerät schnell und wirtschaftlich erstellen.
Tardive dyskinesia and glucid metabolism
Authors: Brousse Georges , Meary Alexandre , Mouret Jacques , Blanc Olivier , Hueber Thierry , Lemoine Philippe , Llorca Pierre‐Michel , Lachaux Bernard 
Published: June 2007

AbstractA role of insulin‐dependent diabetes in the onset of tardive dyskinesia has been reported and relies on weak physiopathological evidence.ObjectiveTo study the relationship between the occurrence of tardive dyskinesia and variations in glucose levels in a population of patients under typical antipsychotic treatment.MethodsSixty‐nine patients with a schizophrenic disorder and who had been receiving continuous neuroleptic treatment for at least 2 years were included. Tardive dyskinesias were assessed by the Abnormal Involuntary Movements Scale (AIMS) and glucose levels by glucose oxidase method.ResultsNo significant differences in values of fasting glucose (FG) levels, post‐prandial glucose (PPG) levels and glycosylated haemoglobin between the groups with and without tardive dyskinesia were found. In the sub‐group with normal FG, comparison of post‐prandial delta glucose levels (difference between PPG and FG) between the two group with and without tardive dyskinesia showed a significant difference (p < 0.05). This comparison also showed a correlation between post‐prandial delta glucose levels and the AIMS score in the group with tardive dyskinesia (r = 0.482, p < 0.05).ConclusionGlucose metabolism could be involved in patients with tardive dyskinesia. Various factors outside antipsychotic treatment can favour a disturbance of glucose metabolism, which may not be severe. Copyright © 2007 John Wiley & Sons, Ltd.
Cytotoxic action of phorbol esters on human pancreatic cancer cells
Authors: Bond Jane A. , Gescher Andreas J. , Verschoyle Richard D. , Lemoine Nicholas R. , Errington Rachel , Wiltshire Marie , Smith Paul J. , Wynford‐Thomas David 
Published: June 2007

AbstractWe previously showed that phorbol esters are cytotoxic to human thyroid epithelial cells expressing a mutant RAS oncogene. Here we explore the generality of this finding using cells derived from pancreatic cancer, which, like thyroid, shows a high frequency of RAS mutation, but is a much greater cause of cancer mortality. The response to phorbol myristate acetate (PMA) and related agents was assessed on a panel of 9 pancreatic cancer cell lines, using a range of assays for cell growth and death in vitro and in vivo. In most lines, PMA induced non‐apoptotic cell death which was, surprisingly, independent of its “classic” target, protein kinase C. With 24 hr exposure, the IC50 in the most sensitive line (Aspc‐1) was <1 ng/ml (1.6 nM), with survival undetectable at concentrations ≥≥16 nM, and after only 1 hr exposure the IC50 was still ≤≤16 nM. Interestingly, the efficacy of a second phorbol ester, phorbol dibutyrate, was much lower, and the PMA analogue bryostatin‐1, which is in clinical trials against other tumour types, was totally inactive. Pre‐treatment of Aspc‐1 cells with PMA before subcutaneous inoculation into nude mice prevented, or greatly retarded, subsequent xenograft tumour growth. Furthermore, treatment of established tumours with a single peri‐tumoral injection of PMA induced extensive cell death and arrested tumour development. Taken together with recent Phase 1 clinical studies, these data suggest that activity against pancreatic cancer will be attainable by systemic administration of PMA, and point to potential novel therapeutic targets for this highly aggressive cancer. © 2007 Wiley‐Liss, Inc.
DNA global hypomethylation in squamous cell head and neck cancer associated with smoking, alcohol consumption and stage
Authors: Smith Ian M. , Mydlarz Wojciech K. , Mithani Suhail K. , Califano Joseph A. 
Published: June 2007

AbstractEpigenetic changes have been implicated in the pathogenesis of solid tumors, including head and neck squamous cell carcinoma (HNSCC). Prior efforts have primarily examined regional promoter hypermethylation as a silencer of tumor suppressor gene expression. To analyze the global state of methylation in the HNSCC genome, we utilize pyrosequencing of repetitive elements (LINEs) to compare the state of global methylation in HNSCC to normal aerodigestive mucosa. 137 samples (119 HNSCC tumors and 18 normal mucosal tissues) were digested to extract DNA and subjected to bisulfite treatment. Treated DNA was amplified using PCR primers for the repetitive LINEs sequence and produced a heterogeneous sample of products, from many genomic loci. These products were pyrosequenced to quantitatively evaluate their global genomic methylation status. HNSCC specimens showed global hypomethylation, with a mean level of genomic methylation of 46.8% methylated with a standard deviation of 9.0. Conversely, the normal upper airway mucosa had a global methylation level of 54.0 and a standard deviation of 4.6 (Mann–Whitney p value < 0.001). The tumor specimens also showed an increasing degree of hypomethylation associated with advanced tumor stage (ANOVA p‐value of 0.003). About 67% of HNSCC's are globally hypomethylated when evaluated against the minimum level of methylation in the normal mucosal specimens. Degree of global hypomethylation was associated with smoking history, alcohol use and stage in univariate analysis (p‐value 0.02), however, only HNSCC diagnosis remained significant on multivariate analysis. Despite the presence of regional promoter hypermethylation, HNSCC demonstrates global genomic hypomethylation. The effects of stage, alcohol use and smoking on global hypomethylation were not independently significant. © 2007 Wiley‐Liss, Inc.