bluuebunny/crossref_metadata_2025_split huggingface dataset:
Infected müllerian adenosarcoma of the endometrium
Authors: Piura Benjamin , Hacay Zion J. , Goldstein Jed 
Published: February 2007

AbstractA 52‐year‐old postmenopausal woman presented with signs and symptoms of acute pelvic inflammatory disease. On vaginal speculum examination, an infected polypoid tumor protruding from a dilated cervical canal was disclosed. While the patient was under extensive antibiotic treatment, uterine curettage was performed. This was followed a few days later by a total abdominal hysterectomy and bilateral salpingo‐oophorectomy. Histopathological examination demonstrated the tumor to be Müllerian adenosarcoma of the uterine endometrium. The patient had postoperative vaginal vault irradiation, and more than 1 year later she is alive with no evidence of recurrent disease. Diagnosis and management of uterine Müllerian adenosarcoma is discussed.
Myasthenic syndrome (eaton‐lambert syndrome) associated with pulmonary adenocarcinoma
Authors: Ramos‐Yeo Yolanda L. , Reyes Cesar V. 
Published: February 2007

AbstractA case of a 57‐year‐old man who presented with the clinical features of. Eaton‐Lambert syndrome preceding the diagnosis of lung adenocarcinoma at autopsy by 7 years, is reported. Although myasthenic syndrome is intimately associated with pulmonary small cell carcinoma, which connotes a grave prognosis, a small percentage of the tumor can be squamous cell carcinoma or adenocarcinoma, which may be resectable. Therefore, a continued search for evidence of intrathoracic neoplasm must be pursued following manifestations of myasthenic syndrome.
Three synchronous bilateral lung tumors: A case report
Authors: Paul Sindy M. , Bacharach Benjamin 
Published: February 2007

AbstractTwo synchronous primary lung carcinomas presenting bilaterally are rare. Their presentation, predisposing factors, and treatment are similar to those of single lung carcinomas. The authors present the first reported case known to them of three synchronous primary lung carcinomas involving both lungs. These tumors fulfill accepted criteria for synchronous tumors—each is malignant, each is anatomically separate and distinct from the other, and each is histologically different and is not a manifestation of metastatic disease.
Five‐year survival after extended resection of colon cancer
Authors: Gardner Bernard 
Published: February 2007

AbstractEleven cases of prolonged survival after extensive resection of colon cancer including neighboring structures are presented. Our understanding of colon cancer as a rapidly invasive but slowly metastasizing tumor has provided the rationale for this approach. Techniques of ureteral and abdominal wall reconstruction are presented. Cures are possible with this approach, and without the availability of adequate chemotherapy aggressive resections remain the mainstay of treatment.
Adenocarcinoma of the duodenum
Authors: Sarma Deba P. , Weilbaecher Thomas G. 
Published: February 2007

AbstractThree patients with carcinoma of the first and the third part of the duodenum are reported. A review of the literature shows the diagnosis of this rare lesion of the duodenum is usually late. In order for surgical resection to be successful, suspicion of such a lesion and an aggressive workup is needed.
Use of the 90Sr applicator for intraoperative radiation therapy in a mouse tumor model
Authors: Hill Helene Z. , Ohanian Maimu , Hill George J. , Winne Richard 
Published: February 2007

AbstractIntraoperative radiation therapy (IORT) research is limited by the lack of small‐animal models. We have implanted B16 melanoma into mouse kidneys, which we subsequently operated upon and irradiated with beta rays from a 90Sr ophthalmic applicator. The IORT has effectively prolonged survival and produced some cures. The strategy should be applicable to other murine tumors and to other internal implantation sites.
Tumor‐associated antigens in bilateral breast cancer
Authors: Lundy Joel , Mishriki Yousri , Varma Andre O. , Kufe Donald , Schuss Allan 
Published: February 2007

AbstractThe purpose of our present study is to determine whether monoclonal antibodies can define an antigenic phenotype which expresses itself in a concordant fashion in synchronous bilateral breast cancer. The monoclonal antibodies DF.3 and B72.3 were reacted (ABC immunoperoxidase) with formalin‐fixed, paraffin‐embedded sections of bilateral synchronous breast cancers from 19 patients. MAb DF.3 demonstrated a P < .01 correlation of right‐sided vs left‐sided reactivity. This suggested that MAb DF .3 could be used as a biologic marker for synchronous bilateral breast cancer. We hypothesized that the majority of clinically asynchronous breast cancers are really biologically synchronous. We used the immunoperoxidase technique in a similar fashion on bilateral metachronous tumors in 17 patients. DF.3 antigen expression correlated (right to left side) at P < .01 value. This data, supported by previous information, suggests that the term “metachronous” breast cancer is a clinically arbitrary definition but that biologically most “metachronous” cancers may well be synchronous.
Hemangiopericytoma of the prostate
Authors: Chen Karl T. K. 
Published: February 2007

AbstractA case of hemangiopericytoma of the prostate is described. The patient presented with a 5‐year history of episodic hematuria and lower urinary tract obstruction. A transurethral resection of the prostate showed a highly cellular mesenchymal tumor exhibiting features of a hemangiopericytoma. He died of concomitant disseminated carcinoma of the lung. An autopsy showed a large prostatic hemangiopericytoma with bladder wall invasion. This case appears to be the fifth reported case of hemangiopericytoma of the prostate.
Factors influencing the growth and metastastic behavior of tumors
Authors: Murthy M. Satya , Travis Jeanne D. , Scanlon Edward F. 
Published: February 2007

AbstractThe factors influencing the growth and metastatic behavior of experimental animal tumors are examined. 104 TA3Ha cells were injected intraperitoneally, intravenously, subcutaneously into the flank, and subcutaneously into the tail tissues of syngeneic strain A mice. The tumor takes from these injections were 50/50 (100%), 1/10 (10%), 10/10 (100%), and 7/12 (60%), respectively. The frequency of lung metastasis from these sites was 0, 100, 50, and 100%, respectively. At the time of host death, the flank and tail tumors were, respectively, 2.2 ± 0.5 cm (geometric mean diameter) and 1.2 ± 0.3 cm in the TA3Ha and 0.9 ± 0.1 cm and 0.4 ± 0.1 cm in the L1210 systems. TA3Ha tumors metastasized regularly to the lymph nodes but the L1210 tumors seldom metastasized to the lymph nodes. Tail implants of TA3Ha tumors behaved similarly in the athymic nude mice and strain A mice. TA3Ha cells inoculated into the Millipore chambers and maintained in mice for > 150 days were viable and able to form tumors. The results demonstrate that the anatomic location of the tumor affects the growth and metastatic behavior of the tumors, and that the tumors of different histologic origin metastasize differently even when grown in corresponding locations.
Fibromatosis of the breast: A case report and literature review
Authors: Thomas Trey , Lorino Cynthia , Ferrara John J. 
Published: February 2007

AbstractFibromatosis is an uncommon, relatively benign though locally infiltrating neoplasm consisting of well‐differentiated fibroblasts surrounded by collagen bundles. The majority of the literature suggests that prevention of local recurrence mandates wide (en bloc) excision. Few more than a dozen cases of primary breast fibromatosis have been reported. Herein the clinical characteristics, diagnostic evaluation, and therapeutic options are presented. Management should be based upon principles utilized for extra‐mammary primary disease–en bloc resection. This may require total mastectomy and removal of pectoralis major muscle. Breast reconstruction should be deferred for a minimum of 3 years, during which time the majority of recurrences will have become manifest.
Subungual melanoma: A 25‐year review of cases
Authors: Daly John M. , Berlin Richard , Urmacher Carlos 
Published: February 2007

AbstractThe purpose of this study was to evaluate subungual melanoma as a site specific entity, to determine the influence of regional nodal involvement, and to ascertain where possible the role of histologic grading of the primary site. Thirty‐three patients with subungual melanoma whose median age was 56 yr underwent treatment between 1950 and 1975. There were 11 male and 22 female patients. Forty‐eight per cent of lesions occurred on the hand. Of 23 clinical stage I patients, seven patients underwent amputation only, while 16 patients underwent amputation and regional nodal dissection. Histologic examination of the primary tumor suggested a trend towards thicker/ulcerated lesions to be associated with metastatic melanoma in regional lymph nodes and/or death due to disease. Early survival patterns favored female patients but there was no significant difference in 10‐year survival when analysed by patient sex. Clinical/pathologic stages were the most significant factors affecting long‐term survival with 5‐ and 10‐year survivals of 66% and 55% in stage I patients and 22% and 0% in stage II patients.
Primary squamous cell carcinoma of the colorectum: Case report and literature review of a rare entity
Authors: Pigott John P. , Williams Gary B. 
Published: February 2007

AbstractA case of primary squamous cell carcinoma of the rectum is presented. Although it is a rare condition, the diagnosis, treatment, and natural history of the disease are similar to that of adenocarcinoma of the colorectum. The patient in this report has done well to date with an abdominal perineal resection and early post‐operative radiation. A review of the literature reveals that the precise etiology of this entity remains unknown.
Sebaceous adenocarcinoma of meibomian gland origin with targetoid intra‐nuclear inclusion
Authors: Goldstein Jed , Avinoah Ilana , Lifshitz Tova 
Published: February 2007

AbstractNeoplastic proliferation of the meibomian glands is most often characterized by a tarsal tumor of the eyelid conjunctiva, having the clinical appearance of a chalazion. As such, the tumor is frequently not recognized as a neoplasm and is treated conservatively as an inflammatory lesion. A protracted clinical course combined with repeated surgical excisions typify this slow‐growing tumor of sebaceous gland cells. In addition to the usual features of polygonal cell shape, abundant cytoplasm, and numerous fat vacuoles, we describe the presence of a peculiar nuclear inclusion seen only in the parenchymal cells of this tumor, and having the appearance of concentric layers of electron‐dense material surrounding an opaque electron lucent core.
Bleomycin‐associated pulmonary fibrosis: Rapidly fatal progression without chest radiotherapy
Authors: Dee Gary J. , Austin John H. M. , Mutter George L. 
Published: February 2007

AbstractTwo patients with carcinoma of the tonsil were treated with bleomycin (396 and 224 units, respectively) but not with radiotherapy. Respiratory insufficiency led to death 45 and 52 days, respectively, after onset of therapy. Chest radiographs before bleomycin therapy revealed no evidence for lung disease. Postmortem examinations showed severe interstitial and intraalveolar pulmonary fibrosis. Comparably rapid progression from radiographically normal pulmonary parenchyma to fatal fibrosis has been documented previously only in patients with thoracic neoplasia as well as, in all but one instance, either prior or concurrent chest radiotherapy. These two cases indicate that chest radiötherapy is not a necessary cofactor for the development of rapidly progressive, fatal, diffuse interstitial pulmonary fibrosis after bleomycin therapy.
Regulation of tumor growth by soluble spleen factors: Effect of tumor resection
Authors: Jasnis Marí Adela , Eiján Ana Marí , Oisgold‐Dagá Sara 
Published: February 2007

AbstractSupernatants of cultured spleen cells (SCS) from small‐tumor‐bearing mice (STBM) and large‐tumor‐bearing mice (LTBM) were tested in vivo by their ability to modify tumor development. We found that when inoculated with S13 tumor cells into the foot‐pad of syngeneic normal BALB/c mice, SCS enhanced tumor growth as well as accelerated tumor takes. When STBM and LTBM were operated on, the persistence of the enhancing activity by SCS was found to be associated with tumor size at the time of tumor removal. As early as 24 hours after small‐tumor resection, enhancing activity disappeared or diminished to undetectable levels. On the other hand, enhancing activity by SCS from large‐tumor‐resected mice (LTRM) persisted until 15 days after surgery, and then faded. Enhancing activity associated with SCS from S13‐tumor‐bearing mice (TBM) was also seen when injected with M3 cells, a syngeneic unrelated tumor. Normal SCS did not affect tumor development. It seems that the rate of disappearance of enhancing activity observed in SCS from S13‐tumor‐resected mice (TRM) is mainly dependent on the size of tumor burden at the time of surgery.
New laser technique for the treatment of malignant esophageal obstruction
Authors: Pietrafitta Joseph J. , Dwyer Richard M. 
Published: February 2007

AbstractEndoscopic laser therapy for malignant esophageal obstruction is rapidly gaining widespread acceptance by the medical community. The standard approach utilizing the neodymium: yttrium, aluminum, garnet (Nd: YAG) laser was first described by Fleischer for squamous cell carcinoma of the esophagus and subsequently for adenocarcinoma of the gastroesophageal junction. According to his technique, treatment was begun at the proximal tumor margin and proceeded distally; as many as 13 treatments were necessary to complete therapy and relieve the obstruction. A new technique has been developed utilizing tumor dilatation so that treatment can be started at the distal tumor margin working retrogradely. This new technique has allowed treatment to be completed in a single session in most patients. This rapid completion of therapy has reduced the length of hospitalization and thereby hospital costs. It has also allowed patients to aliment earlier, thereby minimizing the metabolic consequences of prolonged intravenous feedings, has allowed patients to receive other forms of therapy on an outpatient basis, and has obviated the need for the chronic placement of tubes for drainage and feeding. The technique is described and discussed.
Estrogen and progesterone receptor levels are lower in specimens taken from previously biopsied breast tumor tissue
Authors: Sharoni Yoav , Feldman Bianca , Inbar Ilana , Haruzi Ilan , Levy Joseph 
Published: February 2007

AbstractEstrogen and progesterone receptor (ER and PgR) levels and peroxidase activity were measured in the first biopsy and in tissue removed 4–10 days later during mastectomy of previously biopsied tumor. The proportion of ER‐ and PgR‐positive tumors declined from 71% and 63%, respectively, in the biospy group, to 46% and 36% in the mastectomy group. Peroxidase activity was low or absent in all biospy specimens, but was present in 16 out of 25 tumors which had been biopsied previously. Receptor levels in paired specimens obtained from the same patient were lower in the mastectomy in 14 out of 18 receptor‐positive cases. This decrease in the receptor level was accompanied by a significant increase in peroxidase activity. We suggest that an attempt be made to perform receptor analysis from “virgin” tumor tissues at initial biopsy. If this is not possible, measurement of peroxidase activity could be helpful in evaluating the degree of receptor deterioration.
Management of apparent single foci of epithelial ovarian cancer
Authors: Bruckner Howard W. , Gorbaty Mayer 
Published: February 2007

AbstractFour patients with proven ovarian cancer were found to have single lesions in the liver parenchyma after completing chemotherapy. They otherwise appeared to be in complete clinical remission. Percutaneous needle biopsy was sometimes misleading and dangerous. Laparoscopy and laparotomy were required for optimum safe diagnosis, staging, and treatment. Definitive resection appeared to be beneficial but usually only as a palliative form of debulking. Subsequent adjuvant combination chemotherapy may sometimes improve the duration of useful remissions. Unusual sites of metastatic ovarian cancer appear to be increasing in frequency. Successful management of late recurrences in the liver is possible, provided the diagnosis is immediately suspected and one utilizes both definitive surgery and chemotherapy.
A glucagon‐secreting pancreatic alpha islet cell tumor presenting as spinal cord compression
Authors: Staren E. D. , Steinecker G. A. , Gould V. E. 
Published: February 2007

AbstractWe describe a patient with a pancreatic islet carcinoma presenting with spinal cord compression owing to vertebral metastases. Subsequent studies demonstrated a typical islet cell carcinoma by light microscopy. By electron microscopy, the neurosecretory granules were morphologically suggestive of glucagon production. Radioimmunoassay studies revealed markedly elevated levels of serum glucagon. Notably, the patient did not exhibit the characteristic glucagonoma syndrome. This case exemplifies clearly that elevated levels of immunoreactive neuropeptide hormones are not necessarily associated with overt hormonal syndromes. Possible mechanisms for explaining this apparent discrepancy include the production of immunoreactive molecules with weak or absent systemic biological activity. Nevertheless, the determination of immunoreactive adjunct method for in neuroendocrine neoplasms is an extremely effective adjunct method for their diagnosis and monitoring.
Emergency subtotal colectomy for obstructing carcinoma of the left colon
Authors: Halevy A. , Ponczek M. , Orda R. 
Published: February 2007

AbstractEight patients with obstructing carcinoma of the left colon underwent emergency subtotal colectomy and ileosigmoidostomy or ileoproctostomy. Based on the results obtained by us and those reported in the literature, it is our opinion that emergency subtotal colectomy with primary ileocolonic anastomosis should be considered as the procedure of choice for patients with obstructing carcinoma of the left colon.
Primary pulmonary angiosarcoma associated with multiple synchronous neoplasms
Authors: Ott Richard A. , Eugene John , Kollin Jozef , Kanas Robert J. , Conston David E. , Chi Jocelyn C. H. 
Published: February 2007

AbstractA 60‐year‐old man presented with a 3‐month history of shortness of breath. He was found to have a right thoracic mass involving the right middle and lower lobes, pulmonary hilum, and mediastinum. Diagnosis could not be established by pleural fluid cytology, pleural biopsies, bronchoscopy, and ultrasound‐guided needle biopsies. A diagnostic exploratory thoracotomy was performed. Massive hemorrhage was encountered upon opening the pleura, and bleeding was controlled by performing a radical pneumonectomy. Histology revealed angiosarcoma, pulmonary primary. The patient survived for 68 days. At autopsy, he was found to have adenocarcinoma of the prostate, adenocarcinoma of the rectum, carcinoid of the ileum, and leiomyoblastoma of the stomach as well as diffuse metastases from the angiosarcoma. This represents the fourth reported case of primary pulmonary angiosarcoma.
Primary liver cancer: Pattern of metastasis
Authors: Lee Yeu‐Tsu Margaret , Geer Deborah A. 
Published: February 2007

AbstractThe causes of death and patterns of metastasis of 43 patients with primary liver cancer were studied and discussed in comparison with reports in the literature. Data from 6 recent reports of 1,673 patients showed that the 3 leading causes of death from hepatoma were liver failure (34%), bleeding (30%), and advanced cancer (24%). Distribution of sites of metastasis in 1,497 patients with hepatoma from 7 reports showed that the 3 leading sites were: lung (median 44%), portal vein (35%), and portal lymph node(s) (27%). The pattern of metastasis of hepatoma arising from cirrhotic liver is somewhat different from that of the noncirrhotic liver; the former are more likely to involve the portal vein, whereas the latter involves more regional lymph node(s). Compared to hepatoma, cholangio‐carcinoma is less likely to metastasize to the lung or portal vein, but more likely to involve lymph node(s), peritoneum, and bone and/or marrow.
Triple lumen venous access for pediatric bone marrow transplantation candidates
Authors: Weese James L. , Trigg Michael E. 
Published: February 2007

AbstractMultiple routes of vascular access are required in children undergoing bone marrow transplantation to facilitate total parenteral nutrition (TPN); blood withdrawal; and administration of blood products, antibiotics, fluids, and immunosuppressive drugs. Placement of multiple catheters frequently requires multiple venotomies in separate vessels. We have found that both a Broviac catheter and pediatric dual‐lumen Raaf catheter can be placed through separate venotomies in the external jugular vein, which provides sufficient routes of vascular access without complications. This technique places only one vessel at risk while minimizing the chance for infection by utilizing two exit sites. We consider this to be the procedure of choice in young patients requiring multiple routes of vascular access.
Adjuvant chemotherapy in high‐risk malignant melanoma
Authors: Karakousis Constantine P. , Emrich Lawrence J. 
Published: February 2007

AbstractFifty‐nine patients with regional or hematogenous recurrence of malignant melanoma following resection of all the gross tumor were randomized to observation or chemotherapy. The chemotherapy consisted of BCNU 80 mg/M2 I.V. every 4 weeks, actinomycin‐D 0.01 mg/kg and vincristine 1.0 mg/M2 I.V. every 2 weeks, for a total of 6 months. The chemotherapy protocol was tolerated well without appreciable objective side effects. At a median follow‐up period of 11.5 months, the disease‐free survival time for the chemotherapy treated group is significantly longer than for the control group (P = 0.01). The estimated median disease‐free survival time is 4 months in the surgical control group and 9 months in the chemotherapy group. At present, the proportion of patients remaining disease‐free is 43% for the surgical control and 55% for the chemotherapy treated group. More patients and follow‐up are needed, but this preliminary report suggests that nitrosourea‐based protocols need to be evaluated further as adjuvant treatment of malignant melanoma.
Hepatic intra‐arterial adriamycin in metastatic leiomyosarcoma: Exploiting the steep dose‐response curve
Authors: Khansur Tawfiq , Patel Vipin , Newcomb Martin , Balducci Lodovico 
Published: February 2007

AbstractWe report a case of extensive leiomyosarcoma of the liver that failed on systemic Adriamycin. Hepatic intra‐arterial chemotherapy with Adriamycin has resulted in a lasting clinical remission. This report illustrates the importance of the dose‐response curve of drug to tumor in regional chemotherapy as with Adriamycin used in sarcoma, and the need to further explore such therapy in moderately chemosensitive tumors that are surgically unresectable for anatomic reasons.