bluuebunny/crossref_metadata_2025_split huggingface dataset:
Age constraints on island-arc submarine basalts from geomagnetic paleointensity
Authors: Usui Yoichi , McIntosh Iona , Ishizuka Osamu 
Published: March 2024

AbstractHigh-resolution dating of volcanic rocks is the foundation for understanding the evolution of volcanoes and for estimating possible hazards. However, dating is often difficult for submarine volcanoes, where radiocarbon or other dating is frequently unavailable or imprecise. Here, we report paleointensity results from submarine basalts around Izu-Oshima Island, a typical island-arc volcano, and their bearing on age constraints. Basaltic lava samples were collected from submarine ridges located southeast of Izu-Oshima Island. Rock magnetic data indicate that the samples contain Ti-rich titanomagnetite with blocking temperatures of around 250–400 °C. The magnetic properties of the samples do not change significantly when heated in Ar or vacuum. We apply the Tsunakawa-Shaw method to estimate absolute paleointensity. Samples from different submarine ridges show distinct behavior. One ridge (SE1) shows moderate paleointensity of about 37 μT, while another ridge (SE3) records relatively strong magnetic fields of about 60 μT. Comparing those results with regional paleointensity data, we estimate the age of the SE1 ridge to be younger than 0.5 ka or around 1.4 ka. The other ridge (SE2) exhibits different paleointensity for two samples obtained from different localities, implying that the ridge consists of multiple eruptions. These results demonstrate that paleomagnetism can improve the dating of submarine volcanic rocks.
Graphical Abstract
Prognostic PET [11C]-acetate uptake is associated with hypoxia gene expression in patients with late-stage hepatocellular carcinoma – a bench to bed study
Authors: Chiu Keith Wan Hang , Tan Kel Vin , Yang Xinxiang , Zhu Xiaoqiang , Shi Jingjing , Chiang Chi-Leung , Chan Lawrence , Hui Yuan , Khong Pek-Lan , Man Kwan , Wong Jason Wing Hon 
Published: March 2024

Abstract
Background
Positron Emission Tomography (PET) with combined [18F]-FDG and [11C]-acetate (dual-tracer) is used for the management of hepatocellular carcinoma (HCC) patients, although its prognostic value and underlying molecular mechanism remain poorly understood. We hypothesized that radiotracer uptake might be associated with tumor hypoxia and validated our findings in public and local human HCC cohorts.

Methods
Twelve orthotopic HCC xenografts were established using MHCC97L cells in female nude mice, with 5 having undergone hepatic artery ligation (HAL) to create tumor hypoxia in vivo. Tumors in both Control and HAL-treated xenografts were imaged with [11C]-acetate and [18F]-FDG PET-MR and RNA sequencing was performed on the resected tumors. Semiquantitative analysis of PET findings was then performed, and the findings were then validated on the Cancer Genome Atlas Liver Hepatocellular Carcinoma (TCGA-LIHC) cohort and patients from our institution.

Results
HAL-treated mice showed lower [11C]-acetate (HAL-treated vs. Control, tumor-to-liver SUV ratio (SUVTLR): 2.14[2.05–2.21] vs 3.11[2.75–5.43], p = 0.02) but not [18F]-FDG (HAL-treated vs. Control, SUVTLR: 3.73[3.12–4.35] vs 3.86[3.7–5.29], p = 0.83) tumor uptakes. Gene expression analysis showed the PET phenotype is associated with upregulation of hallmark hypoxia signature. The prognostic value of the hypoxia gene signature was tested on the TCGA-LIHC cohort with upregulation of hypoxia gene signature associated with poorer overall survival (OS) in late-stage (stage III and IV) HCC patients (n = 66, OS 2.05 vs 1.67 years, p = 0.046). Using a local cohort of late-stage HCC patients who underwent dual-tracer PET-CT, tumors without [11C]-acetate uptake are associated with poorer prognosis (n = 51, OS 0.25 versus 1.21 years, p < 0.0001) and multivariable analyses showed [11C]-acetate tumor uptake as an independent predictor of OS (HR 0.17 95%C 0.06–0.42, p < 0.0001).

Conclusions
[11C]-acetate uptake is associated with alteration of tumor hypoxia gene expression and poorer prognosis in patients with advanced HCC.
Iliocaval and iliofemoral venous stenting for obstruction secondary to tumor compression
Authors: Aly Ahmed K. , Moussa Amgad M. , Chevallier Olivier , Kishore Sirish , Petre Elena , Friedman Adie , Bryce Yolanda , Gonzalez Adrian , Camacho Juan , Santos Ernesto , Ridouani Fourat 
Published: March 2024

Abstract
Background
Cancer patients with pelviabdominal masses can suffer from lower extremity symptoms due to venous compression. The effectiveness of venous stenting has been established in extrinsic venous compression in benign conditions like May-Thurner syndrome. In this retrospective study we evaluate the efficacy and safety of caval, iliocaval and iliofemoral venous stenting for cases of extrinsic venous compression caused by malignant masses in cancer patients.

Methods
IRB-approved retrospective review of patients who underwent iliofemoral venography with venoplasty and stenting between January 2018 and February 2022 was performed. Patients with extrinsic venous compression caused by malignant masses were included. Data on patient demographics, pre-procedure symptoms, procedural technique, stent characteristics, outcomes and follow-up were collected. Descriptive statistics were used to assess technical success, clinical success, primary stent patency and adverse events of the procedure.

Results
Thirty-seven patients (19 males, 18 females) who underwent 45 procedures were included. Deep venous thrombosis (DVT) was present in 21 (57%) patients. Twenty-nine patients (78%, 95% CI 62–90%) reported clinical improvement of the presenting symptoms. The median overall survival after the procedure was 4.7 months (95% CI 3.58–5.99). Eight (22%) patients were alive at last follow up with median follow up of 10.33 months (Range 2–25 months). Twenty-six patients had patent stents on their last follow up imaging (70%, 95% CI 61%-91%). Two patients had a small access site hematoma which resolved spontaneously. Two patients developed moderate, and 1 patient developed severe adverse events related to post procedure therapeutic anticoagulation.

Conclusion
Venous stenting is a safe procedure and should be considered as part of the palliative care for patients with debilitating lower extremity symptoms related to iliocaval and iliofemoral venous compression.

Graphical Abstract
Clindamycin use evaluation retrospective observational study in critical care units in Alexandria Main University Hospital
Authors: Shaker Heba Othman , Naguib Manal , Abdelaziz Basant Mohamed , Bourini Marwan Mohamed Salah Eldin El 
Published: March 2024

Abstract
Background
Irrational use of antibiotics in hospitals is one of the main health system problems. It leads to antibiotic resistance, adverse events, treatment failure, total treatment costs, and longer hospital stay. We aim to evaluate clindamycin use in critical care units in our hospital. It is a step to assess and then put strategies to improve the antibiotic use process.

Methods
This is a clindamycin use evaluation retrospective study. It was done in critical care units at Alexandria’s main university hospital. The clinical pharmacists reviewed 99 patients’ prescriptions over the last 4 months, recording patients' demographics, main diagnosis, comorbidities, type of infection, duplication of therapy, dose, the occurrence of diarrhea, serious drug interactions, clindamycin-defined daily dose per 1000 patients’ days), treatment duration and total cost of clindamycin.

Results
A total of 99 patients were included. Clindamycin was prescribed in appropriate indications in 57 patients (57/99 = 57.6%). Prescriptions with inappropriate indications were 42 (42/99 = 42.4%). Duplication of therapy with clindamycin was detected in 32 prescriptions (32.3%). Diarrhea was recorded in 4% of the cases. There were no severe drug interactions with clindamycin. Inappropriate indications were 320 defined Daily Dose (DDD) of total clindamycin consumption (765 DDD) and a cost of 29951.5 LE (42% of total cost). The prescribed dose of clindamycin was correct in all cases.

Conclusion
There is irrational clindamycin use in critical care units in some cases regarding indications and treatment duplication. Although the prescribed doses were correct. Clindamycin misuse increased total consumption and cost.

Trial registration number
NCT05223400 on 2 February 2022.
Hyperparameter inversion of well logs for the simultaneous estimation of volumetric and zone parameters
Authors: Szabó Norbert Péter 
Published: March 2024

We develop a new alternative for the joint inversion of well logs to predict the volumetric and zone parameters in hydrocarbon reservoirs. Porosity, water saturation, shale content, kerogen, and matrix volumes are simultaneously estimated with the tool response function constants with a hyperparameter estimation assisted inversion of the total and spectral natural gamma-ray intensity, neutron porosity, and resistivity logs. We treat the zone parameters, i.e., the physical properties of rock matrix constituents, shale, kerogen, and porefluids, as well as some textural parameters, as hyperparameters and estimate them in a metaheuristic inversion procedure for the entire processing interval. The selection of inversion unknowns is based on parameter sensitivity tests, which indicate that the automated estimation of several zone parameters is favorable, and their possible range can also be specified in advance. In the outer loop of the inversion procedure, we use a real-coded genetic algorithm for the prediction of zone parameters, and we update the volumetric parameters in the inner loop in addition to the fixed values of the zone parameters estimated in the previous step. We apply a linearized inversion process in the inner loop, which allows for the quick prediction of volumetric parameters along with their estimation errors from point to point along a borehole. The derived parameters, such as hydrocarbon saturation and total organic content, indicate good agreement with core laboratory data. The significance of the inversion method is that the zone parameters are extracted directly from the wireline logs, which improves the solution of the forward problem and reduces the cost of core sampling and laboratory measurements. In a field study, we demonstrate the feasibility of the inversion method using real well logs collected from a Miocene tight gas formation situated in the Derecske Trough, Pannonian Basin, East Hungary.
Russian Grain Procurement in a Revolutionary State
Authors: Fraunholtz Peter 
Published: March 2024

Abstract
The Russian provisional government and Bolshevik regime, in their respective efforts to address and resolve the food-supply crisis of 1917–19, sought to modernize state-village relations and mobilize peasant-citizens to contribute to the task according to their ability. Grain registration, an accounting of peasant grain stocks to find “surpluses,” was a continuation of a reformist trend within the state bureaucracy to replace customary means of allotting state obligations with an effort to base them on an assessment of household productive capacity. Evidence from Penza Province suggests that grain registration, both data gathering and interpretation, played a complex role in the evolution of grain procurement policy. The implementation of registration was impacted by local conditions and was embraced when and where it served local interests. Registration contributed to significant tensions within the state apparatus; it exacerbated the growth of the localism that undermined the authority of the hierarchical procurement apparatus. Grain registration revealed the adaptability of peasants and local officials in the face of top-down reform and prompted efforts to enhance state effectiveness. Ultimately, the persistent challenges posed by grain registration forced the regime to abandon registration and to reorganize the provincial apparatus to enhance oversight of local officials.
Safety of Concomitant Cortical and Thalamic Stereoencephalography Explorations in Patients With Drug-Resistant Epilepsies
Authors: Hect Jasmine L. , Mallela Arka N. , Pupi Michael , Anthony Austin , Fogg David , Ho Jonathan , Slingerland Anna L. , Ikegaya Naoki , Abou-Al-Shaar Hussam , Aung Thandar , Gonzalez-Martinez Jorge 
Published: March 2024

BACKGROUND AND OBJECTIVES:
Intracranial electrophysiology of thalamic nuclei has demonstrated involvement of thalamic areas in the propagation of seizures in focal drug-resistant epilepsy. Recent studies have argued that thalamus stereoencephalography (sEEG) may aid in understanding the epileptogenic zone and treatment options. However, the study of thalamic sEEG-associated hemorrhage incidence has not been investigated in a cohort study design. In this article, we present the largest retrospective cohort study of sEEG patients and compare hemorrhage rates between those with and without thalamic sEEG monitoring.

METHODS:
Retrospective chart review of clinical and epilepsy history, electrode implantation, rationale, and outcomes was performed for 76 patients (age 20-69 years) with drug-resistant epilepsy who underwent sEEG monitoring at our institution (2019-2022). A subset of 38% of patients (n = 30) underwent thalamic monitoring of the anterior thalamic nucleus (n = 14), pulvinar nucleus (n = 25), or both (n = 10). Planned perisylvian orthogonal sEEG trajectories were extended to 2- to 3-cm intraparenchymally access thalamic area(s).The decision to incorporate thalamic monitoring was made by the multidisciplinary epilepsy team. Statistical comparison of hemorrhage rate, type, and severity between patients with and without thalamic sEEG monitoring was made.

RESULTS:
Our approach for thalamic monitoring was not associated with local intraparenchymal hemorrhage of thalamic areas or found along extended cortical trajectories, and symptomatic hemorrhage rates were greater for patients with thalamic coverage (10% vs 0%, P = .056), although this was not found to be significant. Importantly, patients with perisylvian electrode trajectories, with or without thalamic coverage, did not experience a higher incidence of hemorrhage (P = .34).

CONCLUSION:
sEEG of the thalamus is a safe and valuable tool that can be used to interrogate the efficacy of thalamic neuromodulation for drug-resistant epilepsy. While patients with thalamic sEEG did have higher incidence of hemorrhage at any monitoring site, this finding was apparently not related to the method of perisylvian implantation and did not involve any trajectories targeting the thalamus.
A TEORIA DA PRÁTICA EM ESTUDOS SOBRE CONSUMO: uma revisão pelo biblioshiny
Authors: Galindo de Mello Victor , Pépece Olga Maria Coutinho 
Published: March 2024

A Teoria da Prática vem apresentando relevantes contribuições para a compreensão dos fenômenos de consumo. Por meio da análise dos elementos da prática (materiais, competências e significados), diferentes atividades humanas podem ser interpretadas. Entretanto, ainda se faz necessária uma atenção de quais temáticas podem ser desenvolvidas dentro da área de administração. O presente estudo tem como objetivo uma análise bibliométrica da temática da Teoria da Prática e Consumo dentro do campo de administração. Buscou-se realizar uma análise bibliométrica nas bases da Scopus e Web of Science. Adotou-se a ferramenta Biblioshiny para realizar as análises descritivas, de co-citação e clusterização temática. Quatro agrupamentos temáticos, sendo as práticas de consumo sustentável, práticas de consumo colaborativo, práticas de compras e práticas alimentares e green-marketing. Como temáticas promissoras para futuras pesquisas, encontram-se temas como práticas de compras e consumo alimentar. Novos direcionamentos de pesquisa podem ser empregados com base nos dados levantados.
Physical compatibility of Xuebijing injection with 53 intravenous drugs during simulated Y-site administration
Authors: Tong Tong , Li Peifang , Ding Haiwen , Huang Ying , Liu Sheng 
Published: March 2024

ObjectiveXuebijing injection (XBJ) is a commonly used herbal medicine injection in China. However, the physical compatibility of XBJ with other intravenous drugs remains unclear. The purpose of this research is to evaluate physical compatibility of Xuebijing injection (XBJ) with 53 intravenous drugs (including 31 Chinese medicine injections and 22 chemicals) during simulated Y-site administration.MethodsY-site administration was simulated in vitro by admixing 0.33 ml/ml XBJ with an equal volume of other diluted 53 intravenous drugs, respectively. Physical compatibility including visual inspection, Tyndall beam, particle limits, turbidity, pH, chromacity value, spectroscopic absorption of 550 nm and 420 nm (A550 nmand A420 nm) were observed and assessed at 0, 1, 2, and 4 h. Physical compatibility was defined as all solutions with no color changes, no gas evolution, particulate formation and no Tyndall beam within 4 hours, turbidity changes <0.5 nephelometric turbidity unit (NTU) compared to 0 h, particle limits allowed by the Chinese Pharmacopoeia (Ch.P) 2020 edition, pH changes <10% compared to 0, chromacity value changes <200 compared to 0 h, or photometrical changes of A420 nm<0.0400 or A550 nm<0.0100 compared to 0 h.ResultsXBJ was physically incompatible with 27 of the 53 intravenous drugs tested, 26 were compatible with XBJ for 4 h.ConclusionsXBJ should not be simultaneously co-administered with 27 of the 53 intravenous drugs during simulated Y-site. If coadministration was inevitable, flushing tube with NS or D5W before and after infusion of XBJ was needed. Assessment included visual inspection, Tyndall beam, turbidity measurement, particle counts, pH measurement, chromacity value measurement and absorption of A550 nmwere proved to be valid and robust for the quality control of infusion and compatibility of Chinese herbal injection.
Fulminant Celiac Disease Presenting in the Postpartum Period
Authors: Kuwelker Saatchi , Soni Riya , Perez-Sanchez Ariadna , Coss Elizabeth , Soni Nilam J. 
Published: March 2024

ABSTRACT
Celiac disease (CD) is an immune-mediated disorder of the small intestine triggered by dietary exposure to gluten in genetically susceptible individuals. Adult CD usually has an insidious onset with gastrointestinal symptoms, most often diarrhea and weight loss. The association between CD and reproductive abnormalities has been well described in the literature, but it is uncommon for CD to initially manifest during pregnancy or the postpartum period. We report a case of adult CD in a previously healthy woman with a life-threatening presentation during the postpartum period.
Antibacterial and yellowing performances of sports underwear fabric with polyamide/silver ion polyurethane filaments
Authors: Zhu Tingting , Wan Ailan 
Published: March 2024

Abstract
To develop antibacterial durability and low yellowing of sports underwear fabric, silver ion polyurethane filaments (Ag+ PUFs) were used as base yarn, and polyamide filaments were used as face yarn. Nine fabric samples with different Ag+ PUF contents (7, 8, 9, 17, 18, and 19%) were prepared. The fabrics were dyed in light, medium, and dark pink. Ag+ PUF was characterized by scanning electron microscopes for the morphology. Antibacterial properties and mechanical properties of Ag+ PUF were measured. The antibacterial durability, yellowing, elastic recovery, air, and moisture permeability were tested, and fuzzy mathematics was used for comprehensive evaluation. The results demonstrated that Ag+ PUF has good antibacterial properties and mechanical properties. The inhibition rates of the fabric against Escherichia coli and Staphylococcus aureus were 100%. When Ag+ PUF content was 18 and 19%, the antibacterial rates of medium pink fabrics both E. coli and S. aureus were 100% after laundering 30 times. The yellowing of the fabric before dyeing was the lowest when Ag+ PUF content was 7%. Compared with before dyeing, the yellowing of the fabric decreased by 19.13 % after dyeing. The comprehensive performance of 3# fabric is the best, and it has antibacterial persistence and low yellowing.
Production strategies for carbon composites and carbon-based adsorbents
Authors: Shyamalagowri Shanmugasundaram , Akila Nallusamy , Raj Suresh Ashwin , Dhivya Dharshini Udhaya Kumar , Murugesan Subbiah , Pavithra Sundaramoorthy 
Published: March 2024

Abstract
Xenobiotics, hazardous compounds, and emerging contaminants contribute risk to the ecosystem, and the most effective way to reduce their harmful effects is to utilize different carbon-based composites and carbon adsorbents. Adsorption is considered a highly effective approach for eliminating pollutants. Various adsorbent materials, such as nanomaterials, natural materials, and biological biomasses, have been recognized as effective adsorbents for different contaminants. Carbon-based adsorbents are often highly flexible for cleanup because of their exceptional physical and chemical characteristics. This review presents the various forms of carbon composites as an adsorbent and their production strategies. The selection of synthesis methods and the operational parameters are found to be the key factors in determining the nature of the adsorbent and its adsorption efficiency. The pretreatment, activation, and coupling of other agents in the production of carbon composites are found to increase the adsorption efficiency of the material. The study extensively concentrated on the advancements in synthesizing carbon-sourced composites and sorbents. The research gap and the -utilization possibilities of diverse carbon composites in the removal of pollutants are also discussed.
“I Have Some Serious Doubts About this Vaccine…” – Generic Conspiracy Beliefs Predict the Acceptance of the Covid-19 Vaccination
Authors: Brohmer Hilmar , Walcher Sonja 
Published: March 2024

Abstract
The start of the Covid-19 vaccine rollout in early 2021 was accompanied by miscommunication from medical and political actors and decision-makers with regard to its availability. In central European countries, it was not clear when and to what extent vaccines would be available to the public. As our main hypothesis, we assumed that uncertainty about the availability of vaccines (vs certainty), as they were stated in media communication, might affect vaccination acceptance in conspiracy believers positively, who are otherwise assumed to have a low acceptance of vaccination. In a large preregistered online study (N = 659), we did not find evidence that media communication relates to vaccination acceptance, but conspiracy believers tended to accept the vaccine more if they were given the option to choose their preferred vaccine. This latter exploratory finding could be confirmed in a follow-up study (N = 199).
Towards optimizing exercise prescription for type 2 diabetes: modulating exercise parameters to strategically improve glucose control
Authors: Marcotte-Chénard Alexis , Little Jonathan P. 
Published: March 2024

Abstract
Type 2 diabetes (T2D) is a complex and multifaceted condition clinically characterized by high blood glucose. The management of T2D requires a holistic approach, typically involving a combination of pharmacological interventions as well as lifestyle changes, such as incorporating regular exercise, within an overall patient-centred approach. However, several condition-specific and contextual factors can modulate the glucoregulatory response to acute or chronic exercise. In an era of precision medicine, optimizing exercise prescription in an effort to maximize glucose lowering effects holds promise for reducing the risk of T2D complications and improving the overall quality of life of individuals living with this condition. Reflecting on the main pathophysiological features of T2D, we review the evidence to highlight how factors related to exercise prescription can be modulated to target improved glucose control in T2D, including the frequency, intensity, total volume, and timing (e.g., pre- vs. post-prandial) of exercise, as well as exercise modality (e.g., aerobic vs. resistance training). We also propose a step-by-step, general framework for clinicians and practitioners on how to personalize exercise prescription to optimize glycemic control in individuals living with T2D.