bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hyperprogression of brain metastases following initiation of immune checkpoint inhibitors
Authors: Jessurun Charissa A. C. , Siddi Francesca , Nawabi Noah L.A. , Hulsbergen Alexander F. C. , Lo Yu Tung , Jha Rohan , Smith Timothy R. , Broekman Marike L. D. 
Published: February 2025

Abstract

Purpose
Immune checkpoint inhibitors (ICI) are increasingly being administered to cancer patients, including those with brain metastases (BMs). However, in a subset of cancer patients, ICI have shown to paradoxically accelerate tumor growth. This phenomenon is known as hyperprogressive disease (HPD). The aim of this study is to investigate the occurrence of HPD following initiation of ICI in BM patients.

Methods
We retrospectively reviewed the charts of 60 surgically treated patients with BMs from non-small cell lung cancer or melanoma who were administered ICI at the Brigham and Women’s Hospital, Boston between July 2008 and July 2018. BM tumor volumes before and after initiation of ICI were collected. HPD was defined as a ‘post-immunotherapy’ tumor growth rate (TGR) > 2 times ‘pre-immunotherapy’ TGR within three months following initiation of ICI.

Results
Among the 25 included patients treated with ICI, five patients showed HPD with an increase of post-immunotherapy TGR ranging from 4.9 to 207.7 times the pre-immunotherapy TGR. The median survival after initiation of ICI was was 8.0 months in the HPD cases and 13 months in the non-HPD patients.

Conclusion
HPD occurred in about 20% of BM patients receiving ICI. More research is necessary to prospectively analyze the occurrence of HPD and identify predictive factors for HPD in BM patients.
Preadmission medications and recent falls in older inpatients: an observational study
Authors: Clarkson Louise , Griffiths Anthony , Ng Shu-Kay , Lam Alfred K. , Khoo Tien K. 
Published: February 2025

Abstract

Background
Falls in older adults might increase due to polypharmacy.

Aim
This study aimed to explore the association between preadmission medications and history of falls in older inpatients.

Method
This observational study of inpatients aged ≥ 65 years was conducted over 4 years at Ballina Hospital, Australia. The Medication Regimen Complexity Index (MRCI), Drug Burden Index (DBI), and Anticholinergic Effect on Cognition (AEC) scores were calculated for preadmission medications. Polypharmacy and falls questionnaires were administered to identify falls in the past 6 months and aptitude toward medication use.

Results
Overall, 194 participants with a mean age of 80.2 (SD 8.0) years were included. The mean daily number of regular medications was 7.8 (SD 3.9) and the mean MRCI score was 22 (SD 12.6). Among the participants, 107 (55%) reported falls in the past 6 months and 47 (24%) reported ≥ 2 falls. Age and hearing impairment were positively associated with falls (p = 0.007 and p = 0.003, respectively). History of falls was positively associated with a MRCI score of ≥ 20 (p = 0.018), an AEC score of ≥ 2 (p = 0.010) and a DBI score of ≥ 1 after adjustment for age (p = 0.041). Forgetting medications was associated with falls (p = 0.043). Antihypertensive use did not increase falls risk.

Conclusion
Implementing a decisive approach to simplify complex medication regimens, along with patient-focused medication management strategies, may help reduce the risk of falls in older adults. Sedatives and anticholinergic medications increase the risk of falls and should be avoided whenever possible.
Linear recurrent sequences providing decomposition law in number fields
Authors: Hori Haruto , Kida Masanari 
Published: February 2025

Abstract
In their recent paper, Rosen, Takeyama, Tasaka, and Yamamoto constructed recurrent sequences that provide a decomposition law of primes in a Galois extension. In this paper, we reconstruct their sequences via the representation theory of finite groups and obtain an explicit description of the sequences.
Success in entrepreneurship: the impact of self-esteem and entrepreneurial orientation
Authors: Gómez-Jorge Fabiola , Bermejo-Olivas Sara , Díaz-Garrido Eloísa , Soriano-Pinar Isabel 
Published: February 2025

Abstract
Self-esteem and entrepreneurial orientation are crucial factors that influence entrepreneurial behavior and performance at both the individual and organizational levels. This study investigates the relationship between self-esteem and entrepreneurial orientation, focusing on how self-esteem may affect attitudes toward entrepreneurship, willingness to take risks, and, ultimately, entrepreneurial success. While previous research has acknowledged the importance of psychological factors in entrepreneurial intention and new venture creation, this study adopts a novel approach by centering self-esteem in the context of entrepreneurship within newly established companies. Given the complexity of the constructs involved, a qualitative approach is well-suited to address the exploratory nature of this research. We conducted a multiple-case study using semi-structured interviews with entrepreneurs from various sectors, which provided valuable insights into their personal experiences during their entrepreneurial journeys. The data were carefully analyzed using the Gioia method, a robust framework suitable for examining complex social phenomena and generating context-sensitive theories. This exploratory approach offers a nuanced understanding of the “how” and “why” behind the phenomena investigated, employing abductive reasoning to connect theory and observation. The results indicate a significant relationship between the variables, suggesting that self-esteem positively influences entrepreneurial orientation and, consequently, entrepreneurial success. These preliminary findings generate hypotheses for future research to further explore these relationships and ultimately validate the conclusions across different contexts. This research offers valuable insights for entrepreneurs, educators, and policymakers to develop strategies and support systems that foster self-esteem, enhance overall well-being, and promote entrepreneurial success.
Patient performance assessment methods for upper extremity rehabilitation in assist-as-needed therapy strategies: a comprehensive review
Authors: Ödemiş Erkan , Baysal Cabbar Veysel , İnci Mustafa 
Published: February 2025

Abstract
This paper aims to comprehensively review patient performance assessment (PPA) methods used in assist-as-needed (AAN) robotic therapy for upper extremity rehabilitation. AAN strategies adjust robotic assistance according to the patient’s performance, aiming to enhance engagement and recovery in individuals with motor impairments. This review categorizes the implemented PPA methods in the literature for the first time in such a wide scope and suggests future research directions to improve adaptive and personalized therapy. At first, the studies are examined to evaluate PPA methods, which are subsequently categorized according to their underlying implementation strategies: position error–based methods, force-based methods, electromyography (EMG), electroencephalography (EEG)-based methods, performance indicator–based methods, and physiological signal–based methods. The advantages and limitations of each method are discussed. In addition to the classification of PPA methods, the current study also examines clinically tested AAN strategies applied in upper extremity rehabilitation and their clinical outcomes. Clinical findings from these trials demonstrate the potential of AAN strategies in improving motor function and patient engagement. Nevertheless, more extensive clinical testing is necessary to establish the long-term benefits of these strategies over conventional therapies. Ultimately, this review aims to guide future developments in the field of robotic rehabilitation, providing researchers with insights into optimizing AAN strategies for enhanced patient outcomes.

Graphical Abstract
Acanthamoeba spp. in Dialysis Water: Assessing the Potential Risk of Transmission to Hemodialysis Patients
Authors: Tolba Mona Mohamed , Elhadad Heba , Abu Kabsha Shaban Hassan , El-Kady Nesma Seyam , Khalil Safia Saleh , Mohamed Amira Hussein , El-Taweel Hend Aly 
Published: February 2025

Abstract

Purpose

Acanthamoeba spp. can colonize various freshwater habitats. They are the causative agents of granulomatous amoebic encephalitis and can harbor many microorganisms. We studied the presence of Acanthamoeba spp. in the water system of a hemodialysis unit and assessed the potential for transmission to hemodialysis patients.

Methods
Water samples collected from pretreatment and posttreatment water of the treatment station and from input and output water of the dialysis machines were cultured on non-nutrient agar supplemented with Escherichia coli. Blood samples from dialysis patients in the unit and from a control group in the same hospital were tested for anti-Acanthamoeba IgG antibodies.

Results

Acanthamoeba spp. were found in posttreatment water. They were more commonly found in the input water samples (79.2%), than in the output water samples (16.7%) (p = 0.001). Anti-Acanthamoeba IgG antibodies were present in 32.9% of patients and were absent in the control group (p = 0.002). The duration of hemodialysis was significantly longer in seropositive patients than in seronegative patients (p = 0.008).

Conclusion
The study highlights the presence of Acanthamoeba spp. in the dialysis system. The relatively high prevalence of anti-Acanthamoeba IgG antibodies and the link between dialysis duration and seropositivity emphasize the importance of rigorous water monitoring.
Analysing Roman itineraries using GIS tooling: the case of the road XIX (mansions from Tude to Luco Augusti)
Authors: Álvarez Patricia A. Argüelles- , Fernández Pedro Trapero- 
Published: February 2025

Abstract
Reconstruction of the Roman road network must be approached from different methodologies of multidisciplinary character. Once the traditional approaches have been exhausted without achieving a historiographical consensus, the problem may appear insurmountable. However, leveraging Geographic Information Systems (GIS) provides an avenue for re-evaluating existing proposals and suggesting more fitting layouts. This can be accomplished through a meticulous analysis that incorporates topographic and non-Euclidean correlations; allowing a more nuanced and accurate understanding of the subject matter than conventional methods might offer. In this context, the aim of this article is to discuss intriguing research points. But also emphasize the importance of multidisciplinary and multi-proxy studies in relation with the Roman terrestrial networks. We explore a case study in the Galician territory, where we have detected methodological shortcomings reconstructing the route of the XIX road: Item Bracaram Asturicam. One of the sections, from Tude to Luco Augusti, has aroused a greater debate, based on several basic problems: (1) the identification of the mansions, (2) the lack of consensus in the measurements of the distances, (3) the miles referred to in the classical sources, and (4) the complex orography of this territory. To propose answers and theories, that may solve the current problems of the description of this route of the XIX road, a multi- proxy approached methodology is proposed. Thus, by applying Geographic Information Systems techniques, we will be able to calculate the optimal path, and compare the results with historical data and archaeological evidence.
Comparative safety and efficacy of new-generation single-layer polytetrafluorethylene- versus polyurethane-covered stents in patients with coronary artery perforation for the RECOVER (REsults after percutaneous interventions with COVERed stents) Investigators
Authors: Voll Felix , Olivecronab Göran , Ferenc Miroslaw , Hellig Farrel , Schlundt Christian , Wöhrle Jochen , Cassese Salvatore , Rottbauer Wolfgang , Witkowski Adam , Xhepa Erion , Kuliczkowski Wiktor , Strauss Lisa , Schrage Benedikt , Joner Michael , von zur Mühlen Constantin , Cook Stephane , Miljak Tomislav , Eggebrecht Holger , Eeckhout Eric , Laugwitz Karl-Ludwig , Monsegu Jacques , Schunkert Heribert , Westermann Dirk , Kastrati Adnan , Dumonteil Nicolas , Birkemeyer Ralf , Kufner Sebastian 
Published: February 2025

Abstract
New-generation single-layer polytetrafluorethylene (PTFE-) or polyurethane (PU-) covered stent (CS) for the treatment of coronary artery perforation (CAP) during PCI offer high procedural efficacy. To evaluate the comparative long-term safety and efficacy of both devices. This is a multicenter pooled analysis of individual data of patients with CAP undergoing implantation of single-layer PTFE-CS or PU-CS. Procedural endpoint was strategy success defined as successful placement of CS and sealing of perforation without surgical conversion. Clinical endpoints were mortality, myocardial infarction (MI), target vessel revascularization (TVR) and definite or probable stent thrombosis (def/prob ST) at 12 months. Seventy patients with CAP underwent implantation of two hundred eight CS, ninety-two PTFE-CS, and one hundred sixteen PU-CS. More than 1 stent was implanted in 13 patients (17.1%) in PTFE-CS group and 19 patients (20.2%) in PU-CS group, P = 0.80. Strategy success was high (96.1% versus 92.5%., P = 0.62). At 12 months, 71 patients (93.2%) in PTFE-CS group versus 79 patients (81%) in the PU-CS were alive, P = 0.05; TVR occurred in 14 patients (28.4%) in PTFE-CS group and 12 patients (17.9%) in PU-CS group, P= 0.54; MI in 1 patient (1.3%) in PTFE-CS group and 1 patients (1.1%) in PU-CS group, P = 0.86. Rates of def/prob ST were comparable 1.3% in PTFE-CS versus 3.1% in PU-CS P = 0.95. A strategy of implantation of a new-generation single-layer PTFE- or PU-CS for the treatment of coronary artery perforation showed high success rates. Both new-generation CS showed favorable and similar clinical safety, in particular with regard to thrombotic events.

Graphical abstract
Comparison of the red fox gut microbiota among different habitat types in southern Anatolia
Authors: Akbaba Burak , Kucukyildirim Sibel , Ünal Hasan 
Published: February 2025

Abstract
Environmental conditions, especially diet, affect the diversity of gut microbiota (GM). This diversity within and between populations may influence the host’s health and fitness and, therefore, play an important role in adaptation. Regarding this, we collected fecal samples from natural, rural, suburban, and urban habitats to reveal the interaction between diet and compositional diversity of GM of a generalist carnivore, the red fox. The prokaryotic diversity of fecal microbiota was investigated by sequencing the 16S rRNA gene V3-V4 regions. A total of 46 archaeal and bacterial phyla were identified, with Bacillota being the most common phylum in most samples. The dominant genera in the GM of the red fox were Collinsella, Fusobacterium, Faecalibacterium, Escherichia-Shigella, and Blautia. Fusobacterium showed higher relative abundance in suburban (16.0%), natural (11.0%), and rural habitats (10.8%) compared to urban habitats (2.0%), indicating dietary differences of the red foxes that feed close to human settlements. Despite the observed differences in specific taxa, the overall microbial diversity remained relatively stable across the habitats. Our study determined the compositional changes of the GM of a wild animal for the first time in the Anatolian peninsula and revealed the effects of dietary changes, especially urbanization, on the diversity of GM of red foxes.
Optimization of volatile fatty acids from food wastes for polyhydroxyalkanoates synthesis
Authors: Moronkola Akeem A. , Oyedeko Kamilu F. K. , Patinvoh Regina J. , Akinbomi Julius G. , Wainaina Steven , Taherzadeh Mohammad J. 
Published: February 2025

Abstract
This study considered production of volatile fatty acids (VFAs) through anaerobic digestion of food wastes for subsequent usage as raw materials for polyhydroxyalkanoates (PHAs) synthesis. Four types of food wastes including yam, plantain, pineapple, and watermelon peels, as well as their combinations, were initially digested anaerobically to determine the food wastes with highest production of VFA concentration. Yam and plantain peel mix was found to produce highest VFA concentration and yield, measuring 12.78 g/l and 0.64gVFA/gVS, respectively. This necessitated the use of the mix in a semi-continuous process for VFA production. For organic loading rate ranges between 1 and 4gVS/m3/day, acetic acid was observed to be dominant VFA accounting for 50.62% of total VFAs produced while butyric acid accounted for 29.84%. The statistical ANOVA regression, based on the experimental values obtained when VFA was used as a carbon source for PHA production, showed that the modeling algorithms provide a reasonably solid estimate of the PHA yield with the highest expected yield of 56.15% PHAs occurring at a VFA concentration of 2 g/l.
Notes on the Cheeger and Colding version of the Reifenberg theorem for metric spaces
Authors: Gigli Nicola , Violo Ivan Yuri 
Published: February 2025

Abstract
The classical Reifenberg’s theorem says that a set which is sufficiently well approximated by planes uniformly at all scales is a topological Hölder manifold. Remarkably, this generalizes to metric spaces, where the approximation by planes is replaced by the Gromov-Hausdorff distance. This fact was shown by Cheeger and Colding (J Differ Geom 46:406–480, 1997) in an appendix of one of their celebrated works on Ricci limit spaces. Given the recent interest around this statement in the growing field of analysis in metric spaces, in this note we provide a self contained and detailed proof of the Cheeger and Colding result. Our presentation substantially expands the arguments in Cheeger and Colding (1997) and makes explicit all the relevant estimates and constructions. As a byproduct we also show a biLipschitz version of this result which, even if folklore among experts, was not present in the literature. This work is an extract from the doctoral dissertation of the second author.
Effectiveness of Home_Positivity: A VR Program for Promoting Positive Mental Health. A Pilot Feasibility Study
Authors: Li Pira Giorgio , Ruini Chiara 
Published: February 2025

Abstract
Virtual reality (VR) has been recently used for the treatment of mental health conditions. While research shows symptom reduction, further investigation is required to ascertain the impact of VR on well-being indicators. This pilot study aims to assess the effectiveness of a new VR software, H.O.M.E (How to Observe and Modify Emotion)_Positivity, in promoting positive mental health, which implies addressing both psychological distress and well-being. A sample of 16 healthy college students participated in a six-session intervention involving individual interviews and VR experiences using H.O.M.E delivered at the university of Bologna. They were assessed before and after intervention and at 3-month follow-up with indicators of negative symptoms (i.e., Depression Anxiety Stress Scales (DASS) and the Negative affect scale of (PANAS) and of well-being (i.e., Mental Health Continuum (MHC) and the Positive Affect (PA) subscale of the PANAS. Moreover, they were asked to report their satisfaction and comments on the experience of the VR software. Following the intervention, participants reported significantly lower scores at DASS and higher scores at MHC and PA. In contrast, NA subscale score did not change significantly after the intervention or at three months follow-up. The results provide support to the use of H.O.M.E_Positivity for the promotion of positive mental health. Participants reported a reduction of psychological distress and improvement in well-being, and they were all highly satisfied and engaged while using the VR software. These findings indicate the potential value of this intervention, particularly in an increasingly digital society.
Wort‑, Begriffs- und Diskursgeschichte in Verbindung. Eine Untersuchung zum Begriff ›Leben‹ in deutschsprachigen Texten des Mittelalters (mit einer Fallstudie zu Wolframs Parzival)
Authors: Schwarzbach-Dobson Michael 
Published: February 2025

Zusammenfassung
Der Beitrag hat drei Zielsetzungen: Erstens soll ein theoretisches Modell skizziert werden, das Überlegungen der Historischen Semantik, der Begriffsgeschichte im Anschluss an Reinhart Koselleck und der Diskurstheorie gleichermaßen berücksichtigt und so Wort‑, Begriffs- und Diskursgeschichte in Verbindung bringt. Dieses Modell soll dann anschließend an einer Untersuchung des Begriffs ›Leben‹ in deutschsprachigen Texten des Mittelalters erprobt werden. Drittens weist eine Fallstudie zum Begriff ›Leben‹ in Wolframs von Eschenbach Parzival auf das Potential des Modells für literarische Analysen im engeren Sinne hin.
Understanding double perovskite BCNF as a CO2 splitting catalyst for industrial decarbonisation
Authors: Zhao Weiwei , Ma Hongkun , Wang Zixuan , Grégoire Benjamin , Lin Ao , Dai Siyuan , Lin Xuefeng , Liang Ting , Chen Jie , Zhang Tongtong , Ding Yulong 
Published: February 2025

Abstract
The foundation industry, particularly the steel sector, is one of the major sources of global CO2 emissions, with each ton of steel produced using iron ores contributing approximately 1.4 (direct reduced iron-based process) to 2 (blast furnace-based process) tons of CO2, with ironmaking accounting for approximately 70% of these emission. Here, we present a study on the potential of using a double perovskite, Ba2Ca0.66Nb0.34FeO6-δ (BCNF), as a CO2 splitting catalyst that converts CO2 into carbon monoxide (CO), a reducing agent in ironmaking, which can be reintegrated into the ironmaking process to enable ‘in-process’ decarbonisation and facilitate close-loop carbon recirculation. The study combines thermodynamic modelling, molecular dynamics simulations, material characterisation, and lab-scale experimental system design, demonstrating the efficiency and practicality of the use of BCNF for CO2 emission reduction at a moderate temperature range. Simultaneous Thermal Analysis and COMSOL-based simulations were employed to optimise reactor design, maximising CO yield. An economic analysis further supports the scalability of this technology for decarbonising the steelmaking industry, which bears significance with the broader applicability to other foundation industrial sectors, including non-ferrous metal smelting, cement, glass, ceramics, and chemicals. This innovation offers a promising pathway towards sustainable industrial practices and contributes to global efforts to address climate change challenges.

Graphical Abstract
An alternative approach to combat multidrug-resistant bacteria: new insights into traditional Chinese medicine monomers combined with antibiotics
Authors: Dai Cunchun , Liu Ying , Lv Fan , Cheng Ping , Qu Shaoqi 
Published: February 2025

Abstract
Antibiotic treatment is crucial for controlling bacterial infections, but it is greatly hindered by the global prevalence of multidrug-resistant (MDR) bacteria. Although traditional Chinese medicine (TCM) monomers have shown high efficacy against MDR infections, the inactivation of bacteria induced by TCM is often incomplete and leads to infection relapse. The synergistic combination of TCM and antibiotics emerges as a promising strategy to mitigate the limitations inherent in both treatment modalities when independently administered. This review begins with a succinct exploration of the molecular mechanisms such as the antibiotic resistance, which informs the antibiotic discovery efforts. We subsequently provide an overview of the therapeutic effects of TCM/antibiotic combinations that have been developed. Finally, the factors that affect the therapeutic outcomes of these combinations and their underlying molecular mechanisms are systematically summarized. This overview offers insights into alternative strategies to treat clinical infections associated with MDR bacteria and the development of novel TCM/antibiotic combination therapies, with the goal of guiding their appropriate usage and further development.