bluuebunny/crossref_metadata_2025_split huggingface dataset:
RETRACTED: Effects of predictive nursing interventions on pressure ulcer in older bedridden patients: A meta‐analysis
Authors: Liu Zhu‐Feng , Meng Juan , Jing Na , Liu Xiao‐Yun 
Published: March 2024

AbstractTo evaluate the effect of predictive nursing interventions on pressure ulcers in elderly bedridden patients by meta‐analysis. Applied computer searches of PubMed, Embase, Google Scholar, Cochrane Library, China National Knowledge Infrastructure and Wanfang databases for randomised controlled trials (RCTs) on the effect of predictive nursing in preventing pressure ulcers in elderly bedridden patients from the database inception to November 2023. Two researchers independently screened the literature, extracted data and performed quality assessment based on inclusion and exclusion criteria. Stata 17.0 software was utilised for data analysis. Eighteen RCTs involving 6504 patients were finally included. The analysis revealed the implementation of predictive nursing interventions had a significant advantage in reducing the incidence of pressure ulcers in elderly bedridden patients compared with conventional nursing (odds ratio [OR] = 0.20, 95% confidence interval [CI]: 0.15–0.28, p < 0.001), while the patients' satisfaction with nursing care was higher (OR = 3.70, 95% CI: 2.99–4.57, p < 0.001). This study shows that the implementation of a predictive nursing interventions for elderly bedridden patients can effectively reduce the occurrence of pressure ulcers and significantly improve patients' satisfaction with nursing care, which is worthy of clinical promotion and application.
Modelling of patient journey in chronic spontaneous urticaria: Increasing awareness and education by shorten patients' disease journey in Germany
Authors: Maurer Marcus , Augustin Matthias , Bauer Sabine , Ekanayake‐Bohlig Swarna , Kircher Philipp , Knöll Anja , Kramps Thomas , Kurzen Hjalmar , Laemmel Sonja , Novak Natalija , Oppel Eva , Pirouzmandi Lal , Rebhan Michael , Reimnitz Ulrich , Richter‐Huhn Grit , Schwarz Beate , Schwichtenberg Uwe , Staubach Petra , Termeer Christian , Thielen Antje , Varga Katarina , von Bubnoff Dagmar , Zink Alexander , Gmeiner Benjamin , Nathan Petra 
Published: March 2024

AbstractBackgroundChronic spontaneous urticaria (CSU) is both physically and emotionally stressful, and guideline recommendations are often not optimally implemented in clinical practice. The objective of this study was to provide an overview on the patient journey in CSU and to develop a mathematical model based on solid data.MethodsThe journey of CSU patients in Germany was traced through literature review and expert meetings that included medical experts, pharmacists and representatives of patient organizations. The current situation's main challenges in the patient journey (education, collaboration and disease management) were discussed in depth. Then, a probabilistic model was developed in a co‐creation approach to simulate the impact of three potential improvement strategies: (1) patient education campaign, (2) medical professional education programme and (3) implementation of a disease management programme (DMP).ResultsChronic spontaneous urticaria patients are severely burdened by delays in diagnosis and optimal medical care. Our simulation indicates that in Germany, it takes on average of 3.8 years for patients to achieve disease control in Germany. Modelling all three optimization strategies resulted in a reduction to 2.5 years until CSU symptom control. On a population level, the proportion of CSU patients with disease control increased from 44.2% to 58.1%.ConclusionsIn principle, effective CSU medications and a disease‐specific guideline are available. However, implementation of recommendations is lagging in practice. The approach of quantitative modelling of the patient journey validates obstacles and shows a clear effect of multiple interventions on the patient journey. The data generated by our simulation can be used to identify strategies for improving patient care. Our approach might helping in understanding and improving the management of patients beyond CSU.
Productivity measurement: Reassessing the production function from micro to macro
Authors: Martin Josh , Riley Rebecca 
Published: March 2024

AbstractThe productivity growth slowdown in advanced economies during the early decades of the 21st century has led to renewed interest in economic measurement. Measured productivity growth has largely evaporated, yet in many ways, the average person is better off than at any time in history and technological advance is ever evident. Are we simply, or at least in part, mismeasuring productivity change? More fundamentally, are we measuring an outdated or otherwise less relevant economic concept? What should and can we measure in the interest of developing evidence‐based policy solutions to support productivity growth? This paper reviews some of the recent advances in economic measurement and points to an expanded productivity measurement research agenda arising from these questions.
Will the real faker please do a shoulder roll? Bodies, labor, and ideology in esports
Authors: Pate George 
Published: March 2024

AbstractEsports and the broader professionalization of playing video games demonstrates the neoliberal project's continuing expansion across new horizons. By transforming leisure into labor and extracting value from play, major gaming and digital media companies extend the commodity life of video games beyond the sale of the games themselves and into the actual play and even spectatorship of the games. As these companies continue to reframe the actual playing and watching of video games as product, the physical performance of the players' bodies becomes increasingly troublesome, a physical disruption of the media corporations' digital feedback loop.
Extinction risk predictions for the world's flowering plants to support their conservation
Authors: Bachman Steven P. , Brown Matilda J. M. , Leão Tarciso C. C. , Nic Lughadha Eimear , Walker Barnaby E. 
Published: March 2024

Summary
More than 70% of all vascular plants lack conservation status assessments. We aimed to address this shortfall in knowledge of species extinction risk by using the World Checklist of Vascular Plants to generate the first comprehensive set of predictions for a large clade: angiosperms (flowering plants, c. 330 000 species).
We used Bayesian Additive Regression Trees (BART) to predict the extinction risk of all angiosperms using predictors relating to range size, human footprint, climate, and evolutionary history and applied a novel approach to estimate uncertainty of individual species‐level predictions.
From our model predictions, we estimate 45.1% of angiosperm species are potentially threatened with a lower bound of 44.5% and upper bound of 45.7%.
Our species‐level predictions, with associated uncertainty estimates, do not replace full global, or regional Red List assessments, but can be used to prioritise predicted threatened species for full Red List assessment and fast‐track predicted non‐threatened species for Least Concern assessments. Our predictions and uncertainty estimates can also guide fieldwork, inform systematic conservation planning and support global plant conservation efforts and targets.
Life course social mobility, race and tooth loss in adulthood: The role of dental health services
Authors: Celeste Roger Keller , Boing Antonio Fernando , Peres Karen Glazer , Peres Marco Aurelio 
Published: March 2024

AbstractObjectivesTo evaluate the extent to which dental care factors in adulthood modify and, at the same time, mediate the association between race/ethnicity and social mobility from childhood to adulthood with two oral health outcomes in adults.MethodsIn 2012, 1222 individuals 20–59 years old participated in the second wave of the Epi‐Floripa Study in Florianopolis, Brazil. Exposures included social mobility based on adulthood and childhood events, dental care in previous years, type of dental care coverage, reason for dental visits and race. The number of missing and decayed teeth were dichotomised as MT >0 and DT >0.ResultsThe prevalence of missing and decayed teeth was 61.9% and 23.0%, respectively. Age–sex adjusted inequalities in decayed and missing teeth among Black and White individuals were 41.2 percentage points (pp) (95% CI: 3.9–78.7) and 53.1 pp (19.5:86.7), respectively. Inequalities between those persistently higher and lower in socioeconomic position were 42.6 pp (14.6–70.7) and 90.0 pp (62.1–100). The Relative Excess of Risk due to Interaction (RERI) was not statistically significant (p < 0.05). Oaxaca‐Blinder decomposition analyses showed that dental care variables accounted for a small proportion of inequalities.ConclusionsThis result implies that dental care is unlikely to significantly reduce or increase oral health inequalities in this particular population.
Meiotic pairing and morphological and yield characterisation of three advanced lines of hexaploid tritordeum (×Tritordeum martini)
Authors: Carvalho Ana , Lima‐Brito José 
Published: March 2024

AbstractHexaploid tritordeum [×Tritordeum martinii A. Pujadas (Poaceae) nothosp. nov.; HchHchAABB] resulted from crosses between wild barley (Hordeum chilense Roem et. Schultz) and durum wheat [Triticum turgidum L. ssp. durum (Desf.) Husn.]. Tritordeum (HT) presents interesting agronomic traits that can be transferred to cultivated wheat. Through the years, several HT lines were developed and characterised. Genomic stability and fertility are expected for advanced HT lines with multiple self‐fertilisation generations. In this work, we analysed the meiotic chromosomal pairing in pollen mother cells (PMCs) of three advanced lines of hexaploid tritordeum (HT9, HT31 and HT67) after fluorescence in situ hybridisation (FISH) performed with genomic DNA from H. chilense and the bread wheat cloned rDNA sequence, pTa71, as probes, and characterised nine morphological and yield‐related traits for three consecutive years in adult plants. As expected, all HT lines showed regular meiotic chromosomal pairing, ensuring plant fertility as previously confirmed by the characterisation of morphological and yield‐related traits in adult plants of preceding generations. Globally, tritordeum is interesting for wheat breeding and has potential as an alternative crop.
Donepezil for dementia with Lewy bodies: meta‐analysis of multicentre, randomised, double‐blind, placebo‐controlled phase II, III, and, IV studies
Authors: Mori Etsuro , Ikeda Manabu , Ohdake Megumi 
Published: March 2024

AbstractBackgroundCurrent evidence for the management of symptoms associated with dementia with Lewy bodies (DLB) using donepezil is limited. We conducted a meta‐analysis of three randomised controlled trials of donepezil in patients with DLB to investigate the overall efficacy of donepezil on Mini‐Mental State Examination (MMSE), Neuropsychiatric Inventory (NPI), and Clinician's Interview‐Based Impression of Change‐plus Caregiver Input (CIBIC‐plus).MethodsA meta‐analysis was performed using the data of 312 patients administered placebo or 10 mg donepezil. Overall mean score differences for MMSE, NPI‐2, and NPI‐10 from baseline to week 12 and their 95% confidence intervals (CI) were estimated. For CIBIC‐plus, which was transformed from a seven‐point grade to a dichotomous outcome (improvements/no improvements), odds ratio (OR) and its 95% CI were estimated. Random‐effects models were used, and heterogeneity was evaluated using the Cochrane's Q test and I2 statistic.ResultsHeterogeneity was suspected for NPI‐2 (P < 0.05; I2 = 87.2%) and NPI‐10 (P < 0.05; I2 = 67.7%) while it was not suspected for MMSE (P = 0.23; I2 = 32.4%) and CIBIC‐plus (P = 0.26; I2 = 19.8%). The overall mean MMSE score difference (mean difference: 1.50; 95% CI, 0.67–2.34) and the overall odds of improving CIBIC‐plus (OR: 2.20; 95% CI, 1.13–4.26) from baseline to week 12 were higher in the donepezil group than in the placebo group.ConclusionResults of our meta‐analysis indicated overall efficacy of donepezil on cognitive impairment and global clinical status in patients with DLB.
Self‐Employment, the COVID‐19 Pandemic, and the Rural–Urban Divide in the United States☆
Authors: Mindes Samuel C. H. 
Published: March 2024

AbstractSelf‐employed individuals faced numerous challenges amid the global health and economic crisis that was the COVID‐19 pandemic. Similarly, rural and urban workers faced different challenges during the pandemic. This rural–urban disparity further complicates the impacts of self‐employment and exacerbates inequalities resulting from gender, race, ethnicity, or immigration status. This study examines the economic consequences of the COVID‐19 pandemic across these categories in the United States using Current Population Survey data from May 2020 to May 2022. Comparing the wage and self‐employment sectors across rural and urban areas, I examine the effects of individual, business, and geographic characteristics on the probability of work stoppages due to the health crisis. The analysis reveals that recovery from the pandemic was delayed among the self‐employed, while additional education and full‐time employment status can reduce work interruptions for these workers, as does working in select industries. Findings suggest that rural and urban minorities are more likely to face pandemic‐related work disruptions, with key differences between formal and informal self‐employment sectors. Specifically, self‐employed Asians/Pacific Islanders and Native Americans were more adversely affected in rural areas. The study concludes with several policy and program recommendations to assist vulnerable workers, especially in the rural self‐employment sector.
Spectral and linear stability of peakons in the Novikov equation
Authors: Lafortune Stéphane 
Published: March 2024

AbstractThe Novikov equation is a peakon equation with cubic nonlinearity, which, like the Camassa–Holm and the Degasperis–Procesi, is completely integrable. In this paper, we study the spectral and linear stability of peakon solutions of the Novikov equation. We prove spectral instability of the peakons in . To do so, we start with a linearized operator defined on and extend it to a linearized operator defined on weaker functions in . The spectrum of the linearized operator in is proven to cover a closed vertical strip of the complex plane. Furthermore, we prove that the peakons are spectrally unstable on and linearly and spectrally stable on . The result on is in agreement with previous work about linear instability and our result on is in line with past work on orbital stability.
The use of a sling suture for ventral orbital stabilization after inferior orbitectomy in three dogs
Authors: Logothetou Vasileia , Almansa Ruiz José C. , Steenkamp Gerhard 
Published: March 2024

AbstractObjectiveTo describe a novel surgical technique for the ventral stabilization of the orbit after inferior orbitectomy by using a sling suture and report outcomes in three dogs.AnimalsA 7‐year‐old male neutered Swiss shepherd, a 4‐year‐old female neutered golden retriever and a 9‐year‐old female neutered Rhodesian ridgeback.Study designShort case series.MethodsAll dogs presented with caudal unilateral maxillary masses. Surgical resection necessitated a caudal maxillectomy and inferior orbitectomy with a combined dorsolateral and intraoral approach. A sling suture was used to support the globe. A nylon suture was placed rostrally through the osteotomized maxilla and caudally through the osteotomized zygomatic arch via predrilled holes. The suture was tightened until the position of the globe subjectively appeared normal and was secured with a surgeon's knot. The periorbita was secured over the nylon suture with poliglecaprone suture material in a simple interrupted or continuous pattern. The surgical approach was routinely closed.ResultsFollow‐up ranged from 7 to 63 days. The surgical wounds healed uneventfully, and no postoperative complications associated with the stabilization technique were noted. No orbital deviation was noted and the zygomatic regions appeared subjectively symmetrical.ConclusionThe nylon sling suture provided a quick, easy, safe and effective technique to stabilize the ventral orbit during a combined maxillectomy and orbitectomy in dogs.
Integrating high-throughput analysis to create an atlas of replication origins in
Trypanosoma cruzi
in the context of genome structure and variability
Authors: Vitarelli Marcela de Oliveira , Franco Thiago Andrade , Pires David da Silva , Lima Alex Ranieri Jerônimo , Viala Vincent Louis , Kraus Amelie Johanna , de Azevedo Inácio de Loiola Meirelles Junqueira , da Cunha Julia Pinheiro Chagas , Elias Maria Carolina 
Published: March 2024

ABSTRACT

Trypanosoma cruzi
is the etiologic agent of the most prevalent human parasitic disease in Latin America, Chagas disease. Its genome is rich in multigenic families that code for virulent antigens and are present in the rapidly evolving genomic compartment named Disruptive. DNA replication is a meticulous biological process in which flaws can generate mutations and changes in chromosomal and gene copy numbers. Here, integrating high-throughput and single-molecule analyses, we were able to identify Predominant, Flexible, and Dormant Orc1Cdc6-dependent origins as well as Orc1Cdc6-independent origins. Orc1Cdc6-dependent origins were found in multigenic family loci, while independent origins were found in the Core compartment that contains conserved and hypothetical protein-coding genes, in addition to multigenic families. In addition, we found that Orc1Cdc6 density is related to the firing of origins and that Orc1Cdc6-binding sites within fired origins are depleted of a specific class of nucleosomes that we previously categorized as dynamic. Together, these data suggest that Orc1Cdc6-dependent origins may contribute to the rapid evolution of the Disruptive compartment and, therefore, to the success of
T. cruzi
infection and that the local epigenome landscape is also involved in this process.

IMPORTANCE

Trypanosoma cruzi
, responsible for Chagas disease, affects millions globally, particularly in Latin America. Lack of vaccine or treatment underscores the need for research. Parasite’s genome, with virulent antigen-coding multigenic families, resides in the rapidly evolving Disruptive compartment. Study sheds light on the parasite’s dynamic DNA replication, discussing the evolution of the Disruptive compartment. Therefore, the findings represent a significant stride in comprehending
T. cruzi
’s biology and the molecular bases that contribute to the success of infection caused by this parasite.
Biogenesis, germination, and pathogenesis of
Cryptococcus
spores
Authors: Ortiz Sébastien C. , Hull Christina M. 
Published: March 2024

SUMMARY

Spores are primary infectious propagules for the majority of human fungal pathogens; however, relatively little is known about their fundamental biology. One strategy to address this deficiency has been to develop the basidiospores of
Cryptococcus
into a model for pathogenic spore biology. Here, we provide an update on the state of the field with a comprehensive review of the data generated from the study of
Cryptococcus
basidiospores from their formation (sporulation) and differentiation (germination) to their roles in pathogenesis. Importantly, we provide support for the presence of basidiospores in nature, define the key characteristics that distinguish basidiospores from yeast cells, and clarify their likely roles as infectious particles. This review is intended to demonstrate the importance of basidiospores in the field of
Cryptococcus
research and provide a solid foundation from which researchers who wish to study sexual spores in any fungal system can launch their studies.
Comparative analysis of IR-Biotyper, MLST, cgMLST, and WGS for clustering of vancomycin-resistant
Enterococcus faecium
in a neonatal intensive care unit
Authors: Park Sunggyun , Ryoo Namhee 
Published: March 2024

ABSTRACT

Healthcare-associated infections caused by vancomycin-resistant
Enterococcus faecium
(VREFM) pose a significant threat to healthcare. Confirming the relatedness of the bacterial isolates from different patients is challenging. We aimed to assess the efficacy of IR-Biotyper, multilocus sequencing typing (MLST), and core-genome MLST (cgMLST) in comparison with whole-genome sequencing (WGS) for outbreak confirmation in the neonatal intensive care unit (NICU). Twenty VREFM isolates from four neonates and ten control isolates from unrelated patients were analyzed. Genomic DNA extraction, MLST, cgMLST, and WGS were performed. An IR-Biotyper was used with colonies obtained after 24 h of incubation on tryptic soy agar supplemented with 5% sheep blood. The optimal clustering cutoff for the IR-Biotyper was determined by comparing the results with WGS. Clustering concordance was assessed using the adjusted Rand and Wallace indices. MLST and cgMLST identified sequence types (ST) and complex types (CT), revealing suspected outbreak isolates with a predominance of ST17 and CT6553, were confirmed by WGS. For the IR-Biotyper, the proposed optimal clustering cut-off range was 0.106–0.111. Despite lower within-run precision, of the IR-Biotyper, the clustering concordance with WGS was favorable, meeting the criteria for real-time screening. This study confirmed a nosocomial outbreak of VREFM in the NICU using an IR-Biotyper, showing promising results compared to MLST. Although within-run precision requires improvement, the IR-Biotyper demonstrated high discriminatory power and clustering concordance with WGS. These findings suggest its potential as a real-time screening tool for the detection of VREFM-related nosocomial outbreaks.

IMPORTANCE

In this study, we evaluated the performance of the IR-Biotyper in detecting nosocomial outbreaks caused by vancomycin-resistant
Enterococcus faecium
, comparing it with MLST, cgMLST, and WGS. We proposed a cutoff that showed the highest concordance compared to WGS and assessed the within-run precision of the IR-Biotyper by evaluating the consistency in genetically identical strain when repeated in the same run.
Activities of daily living and non-exercise physical activity in older
adults: findings from the Chinese Longitudinal Healthy Longevity
Survey
Authors: Zhou Zhengcheng , Fu Jiehui , Shen Ziyang , Qiu Yuexin , Yang Junsai , Chen Xiaoyun , Li Yue , Zheng Huilie 
Published: March 2024

Objectives
Studies have shown that good cognitive function can moderate the
relationship between non-exercise physical activity (NEPA) and
activities of daily living (ADLs) disability to some extent, and this
study mainly explores the relationship between ADL and NEPA and
cognitive function in Chinese older adults.

Setting and participants
Data came from a nationally representative sample of 2471 Chinese
old adults (aged 65+) from the 2011, 2014 and 2018 waves of the Chinese
Longitudinal Healthy Longevity Survey.

Primary and secondary outcome measures
A cross-lagged panel model combined with mediation analysis was used
to determine the relationship between ADL and NEPA and the mediating
effect of cognitive function on the ascertained ADL–NEPA
relationship.

Results
The more frequently people over the age of 65 in China participate
in NEPA, the lower the risk of ADL disability. Cognitive function
partially mediated this expected relationship, accounting for 9.09% of
the total NEPA effect on ADL.

Conclusion
Participating in more NEPA could reduce the risk of ADL disability,
and participating in NEPA may reduce the risk of ADL disability through
cognitive function to some extent.