bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biogenerated Oxygen‐Related Environmental Stressed Apoptotic Vesicle Targets Endothelial Cells
Authors: Zhao Qiuyu , Lu Bolun , Qian Shutong , Mao Jiayi , Zhang Liucheng , Zhang Yuguang , Mao Xiyuan , Cui Wenguo , Sun Xiaoming 
Published: March 2024

AbstractThe dynamic balance between hypoxia and oxidative stress constitutes the oxygen‐related microenvironment in injured tissues. Due to variability, oxygen homeostasis is usually not a therapeutic target for injured tissues. It is found that when administered intravenously, mesenchymal stem cells (MSCs) and in vitro induced apoptotic vesicles (ApoVs) exhibit similar apoptotic markers in the wound microenvironment where hypoxia and oxidative stress co‐existed, but MSCs exhibited better effects in promoting angiogenesis and wound healing. The derivation pathway of ApoVs by inducing hypoxia or oxidative stress in MSCs to simulate oxygen homeostasis in injured tissues is improved. Two types of oxygen‐related environmental stressed ApoVs are identified that directly target endothelial cells (ECs) for the accurate regulation of vascularization. Compared to normoxic and hypoxic ones, oxidatively stressed ApoVs (Oxi‐ApoVs) showed the strongest tube formation capacity. Different oxygen‐stressed ApoVs deliver similar miRNAs, which leads to the broad upregulation of EC phosphokinase activity. Finally, local delivery of Oxi‐ApoVs‐loaded hydrogel microspheres promotes wound healing. Oxi‐ApoV‐loaded microspheres achieve controlled ApoV release, targeting ECs by reducing the consumption of inflammatory cells and adapting to the proliferative phase of wound healing. Thus, the biogenerated apoptotic vesicles responding to oxygen‐related environmental stress can target ECs to promote vascularization.
Carbonized Cellulose Aerogel Derived from Waste Pomelo Peel for Rapid Hemostasis of Trauma‐Induced Bleeding
Authors: Wan Wenbing , Feng Yang , Tan Jiang , Zeng Huiping , Jalaludeen Rafeek Khan , Zeng Xiaoxi , Zheng Bin , Song Jingchun , Zhang Xiyue , Chen Shixuan , Pan Jingye 
Published: March 2024

AbstractUncontrollable massive bleeding caused by trauma will cause the patient to lose a large amount of blood and drop body temperature quickly, resulting in hemorrhagic shock. This study aims to develop a hemostatic product for hemorrhage management. In this study, waste pomelo peel as raw material is chosen. It underwent processes of carbonization, purification, and freeze‐drying. The obtained carbonized pomelo peel (CPP) is hydrophilic and exhibits a porous structure (nearly 80% porosity). The water/blood absorption ratio is significantly faster than the commercial Gelfoam and has a similar water/blood absorption capacity. In addition, the CPP showed a water‐triggered shape‐recoverable ability. Moreover, the CPP shows ideal cytocompatibility and blood compatibility in vitro and favorable tissue compatibility after long terms of subcutaneous implantation. Furthermore, CPP can absorb red blood cells and fibrin. It also can absorb platelets and activate platelets, and it is capable of achieving rapid hemostasis on the rat tail amputation and hepatectomized hemorrhage model. In addition, the CPP not only can quickly stop bleeding in the rat liver‐perforation and rabbit heart uncontrolled hemorrhage models, but also promotes rat liver and rabbit heart tissue regeneration in situ. These results suggest the CPP has shown great potential for managing uncontrolled hemorrhage.
An Antibody‐Drug Conjugate for Multiple Myeloma Prepared by Multi‐Arm Linkers
Authors: Yu Yueh‐Hsiang , Tian Wei‐Ting , Grauffel Cédric , Lin Wei‐Chen , Hsieh Ming‐Yu , Wu Pei‐Wen , Lee Hui‐Ju , Peng Chi‐Jiun , Lin Pei‐Hsuan , Chu Hsing‐Mao , Lim Carmay , Chang Tse Wen 
Published: March 2024

AbstractFirst‐line treatment of multiple myeloma, a prevalent blood cancer lacking a cure, using anti‐CD38 daratumumab antibody and lenalidomide is often inadequate due to relapse and severe side effects. To enhance drug safety and efficacy, an antibody‐drug conjugate, TE‐1146, comprising six lenalidomide drug molecules site‐specifically conjugated to a reconfigured daratumumab to deliver cytotoxic lenalidomide to tumor cells is developed. TE‐1146 is prepared using the HighDAR platform, which employs i) a maleimide‐containing “multi‐arm linker” to conjugate multiple drug molecules creating a drug bundle, and ii) a designed peptide with a Zn2+‐binding cysteine at the C‐termini of a reconfigured daratumumab for site‐specific drug bundle conjugation. It is shown that TE‐1146 remains intact and effectively enters CD38‐expressing tumor cells, releasing lenalidomide, leading to enhanced cell‐killing effects compared to lenalidomide/daratumumab alone or their combination. This reveals the remarkable potency of lenalidomide once internalized by myeloma cells. TE‐1146 precisely delivers lenalidomide to target CD38‐overexpressing tumor cells. In contrast, lenalidomide without daratumumab cannot easily enter cells, whereas daratumumab without lenalidomide relies on Fc‐dependent effector functions to kill tumor cells.
Thermodynamic Origin‐Based In Situ Electrochemical Construction of Reversible p‐n Heterojunctions for Optimal Stability in Potassium Ion Storage
Authors: Shen Wei‐Wen , Hsieh Yi‐Yen , Yang Yi‐Chun , Hsiao Kai‐Yuan , Lu Ming‐Yen , Chou Chi Wei , Tuan Hsing‐Yu 
Published: March 2024

AbstractHeterojunctions in electrode materials offer diverse improvements during the cycling process of energy storage devices, such as volume change buffering, accelerated ion/electron transfer, and better electrode structure integrity, however, obtaining optimal heterostructures with nanoscale domains remains challenging within constrained materials. A novel in situ electrochemical method is introduced to develop a reversible CuSe/PSe p‐n heterojunction (CPS‐h) from Cu3PSe4 as starting material, targeting maximum stability in potassium ion storage. The CPS‐h formation is thermodynamically favorable, characterized by its superior reversibility, minimized diffusion barriers, and enhanced conversion post K+ interaction. Within CPS‐h, the synergy of the intrinsic electric field and P‐Se bonds enhance electrode stability, effectively countering the Se shuttling phenomenon. The specific orientation between CuSe and PSe leads to a 35° lattice mismatch generates large space at the interface, promoting efficient K ion migration. The Mott‐Schottky analysis validates the consistent reversibility of CPS‐h, underlining its electrochemical reliability. Notably, CPS‐h demonstrates a negligible 0.005% capacity reduction over 10,000 half‐cell cycles and remains stable through 2,000 and 4,000 cycles in full cells and hybrid capacitors, respectively. This study emphasizes the pivotal role of electrochemical dynamics in formulating highly stable p‐n heterojunctions, representing a significant advancement in potassium‐ion battery (PIB) electrode engineering.
Pregnane X Receptor Activation in Liver Macrophages Protects against Endotoxin‐Induced Liver Injury
Authors: Zhao Tingting , Zhong Guoping , Wang Ying , Cao Renjie , Song Shaofei , Li Yuan , Wan Guohui , Sun Haiyan , Huang Min , Bi Huichang , Jiang Yiming 
Published: March 2024

AbstractEndotoxemia‐related acute liver injury has a poor prognosis and high mortality, and macrophage polarization plays a central role in the pathological process. Pregnane X receptor (PXR) serves as a nuclear receptor and xenosensor, safeguarding the liver from toxic stimuli. However, the effect and underlying mechanism of PXR activation on endotoxemic liver injury remain largely unknown. Here, the expression of PXR is reported in human and murine macrophages, and PXR activation modified immunotypes of macrophages. Moreover, PXR activation significantly attenuated endotoxemic liver injury and promoted macrophage M2 polarization. Macrophage depletion by GdCl3 confirmed the essential of macrophages in the beneficial effects observed with PXR activation. The role of PXR in macrophages is further validated using AAV8‐F4/80‐Pxr shRNA‐treated mice; the PXR‐mediated hepatoprotection is impaired, and M2 polarization enhancement is blunted. Additionally, treatment with PXR agonists inhibited lipopolysaccharide (LPS)‐induced M1 polarization and favored M2 polarization in BMDM, Raw264.7, and THP‐1 cells. Further analyses revealed an interaction between PXR and p‐STAT6 in vivo and in vitro. Moreover, blocking Pxr or Stat6 abolished the PXR‐induced polarization shift. Collectively, macrophage PXR activation attenuated endotoxin‐induced liver injury and regulated macrophage polarization through the STAT6 signaling pathway, which provided a potential therapeutic target for managing endotoxemic liver injury.
Histone H3K9 Lactylation Confers Temozolomide Resistance in Glioblastoma via LUC7L2‐Mediated MLH1 Intron Retention
Authors: Yue Qu , Wang Zhao , Shen Yixiong , Lan Yufei , Zhong Xiangyang , Luo Xin , Yang Tao , Zhang Manqing , Zuo Boming , Zeng Tianci , Lu Jiankun , Wang Yuankai , Liu Boyang , Guo Hongbo 
Published: March 2024

AbstractTemozolomide (TMZ) resistance remains the major obstacle in the treatment of glioblastoma (GBM). Lactylation is a novel post‐translational modification that is involved in various tumors. However, whether lactylation plays a role in GBM TMZ resistance remains unclear. Here it is found that histone H3K9 lactylation (H3K9la) confers TMZ resistance in GBM via LUC7L2‐mediated intron 7 retention of MLH1. Mechanistically, lactylation is upregulated in recurrent GBM tissues and TMZ‐resistant cells, and is mainly concentrated in histone H3K9. Combined multi‐omics analysis, including CUT&Tag, SLAM‐seq, and RNA‐seq, reveals that H3K9 lactylation is significantly enriched in the LUC7L2 promoter and activates LUC7L2 transcription to promote its expression. LUC7L2 mediates intron 7 retention of MLH1 to reduce MLH1 expression, and thereby inhibit mismatch repair (MMR), ultimately leading to GBM TMZ resistance. Of note, it is identified that a clinical anti‐epileptic drug, stiripentol, which can cross the blood–brain barrier and inhibit lactate dehydrogenase A/B (LDHA/B) activity, acts as a lactylation inhibitor and renders GBM cells more sensitive to TMZ in vitro and in vivo. These findings not only shed light on the mechanism of lactylation in GBM TMZ resistance but also provide a potential combined therapeutic strategy for clinical GBM treatment.
Diet Mediate the Impact of Host Habitat on Gut Microbiome and Influence Clinical Indexes by Modulating Gut Microbes and Serum Metabolites
Authors: Zhang Jiguo , Qi Houbao , Li Meihui , Wang Zhihong , Jia Xiaofang , Sun Tianyong , Du Shufa , Su Chang , Zhi Mengfan , Du Wenwen , Ouyang Yifei , Wang Pingping , Huang Feifei , Jiang Hongru , Li Li , Bai Jing , Wei Yanli , Zhang Xiaofan , Wang Huijun , Zhang Bing , Feng Qiang 
Published: March 2024

AbstractThe impact of external factors on the human gut microbiota and how gut microbes contribute to human health is an intriguing question. Here, the gut microbiome of 3,224 individuals (496 with serum metabolome) with 109 variables is studied. Multiple analyses reveal that geographic factors explain the greatest variance of the gut microbiome and the similarity of individuals’ gut microbiome is negatively correlated with their geographic distance. Main food components are the most important factors that mediate the impact of host habitats on the gut microbiome. Diet and gut microbes collaboratively contribute to the variation of serum metabolites, and correlate to the increase or decrease of certain clinical indexes. Specifically, systolic blood pressure is lowered by vegetable oil through increasing the abundance of Blautia and reducing the serum level of 1‐palmitoyl‐2‐palmitoleoyl‐GPC (16:0/16:1), but it is reduced by fruit intake through increasing the serum level of Blautia improved threonate. Besides, aging‐related clinical indexes are also closely correlated with the variation of gut microbes and serum metabolites. In this study, the linkages of geographic locations, diet, the gut microbiome, serum metabolites, and physiological indexes in a Chinese population are characterized. It is proved again that gut microbes and their metabolites are important media for external factors to affect human health.
Non‐Metal Ion Storage in Zinc‐Organic Batteries
Authors: Song Ziyang , Miao Ling , Lv Yaokang , Gan Lihua , Liu Mingxian 
Published: March 2024

AbstractZinc‐organic batteries (ZOBs) are receiving widespread attention as up‐and‐coming energy‐storage systems due to their sustainability, operational safety and low cost. Charge carrier is one of the critical factors affecting the redox kinetics and electrochemical performances of ZOBs. Compared with conventional large‐sized and sluggish Zn2+ storage, non‐metallic charge carriers with small hydrated size and light weight show accelerated interfacial dehydration and fast reaction kinetics, enabling superior electrochemical metrics for ZOBs. Thus, it is valuable and ongoing works to build better ZOBs with non‐metallic ion storage. In this review, versatile non‐metallic cationic (H+, NH4+) and anionic (Cl−, OH−, CF3SO3−, SO42−) charge carriers of ZOBs are first categorized with a brief comparison of their respective physicochemical properties and chemical interactions with redox‐active organic materials. Furthermore, this work highlights the implementation effectiveness of non‐metallic ions in ZOBs, giving insights into the impact of ion types on the metrics (capacity, rate capability, operation voltage, and cycle life) of organic cathodes. Finally, the challenges and perspectives of non‐metal‐ion‐based ZOBs are outlined to guild the future development of next‐generation energy communities.
Enhanced Reactivities of Iron(IV)‐Oxo Porphyrin Species in Oxidation Reactions Promoted by Intramolecular Hydrogen‐Bonding
Authors: Gong Zhe , Wang Liwei , Xu Yiran , Xie Duanfeng , Qi Xiaotian , Nam Wonwoo , Guo Mian 
Published: March 2024

AbstractHigh‐valent iron‐oxo species are one of the common intermediates in both biological and biomimetic catalytic oxidation reactions. Recently, hydrogen‐bonding (H‐bonding) has been proved to be critical in determining the selectivity and reactivity. However, few examples have been established for mechanistic insights into the H‐bonding effect. Moreover, intramolecular H‐bonding effect on both C‐H activation and oxygen atom transfer (OAT) reactions in synthetic porphyrin model system has not been investigated yet. In this study, a series of heme‐containing iron(IV)‐oxo porphyrin species with or without intramolecular H‐bonding are synthesized and characterized. Kinetic studies revealed that intramolecular H‐bonding can significantly enhance the reactivity of iron(IV)‐oxo species in OAT, C‐H activation, and electron‐transfer reactions. This unprecedented unified H‐bonding effect is elucidated by theoretical calculations, which showed that intramolecular H‐bonding interactions lower the energy of the anti‐bonding orbital of iron(IV)‐oxo porphyrin species, resulting in the enhanced reactivities in oxidation reactions irrespective of the reaction type. To the best of the knowledge, this is the first extensive investigation on the intramolecular H‐bonding effect in heme system. The results show that H‐bonding interactions have a unified effect with iron(IV)‐oxo porphyrin species in all three investigated reactions.
Rational Combination of π‐Conjugated and Non‐π‐Conjugated Groups Achieving Strong Nonlinear Optical Response, Large Optical Anisotropy, and UV Light‐Switchable Fluorescence
Authors: Dou Danyang , Shi Qi , Li Huimin , Zhang Bingbing , Yang Daqing , Wang Ying 
Published: March 2024

AbstractCombining π‐conjugated and non‐π‐conjugated groups is an important strategy for synthesizing new nonlinear optical (NLO) crystals. However, the second harmonic generation (SHG) response and optical anisotropy can be limited by improper spatial alignment of these functional groups in the crystal structure. In this work, it is revealed that non‐π‐conjugated [NH2SO3] group acts as both hydrogen bond donor and acceptor, effectively regulating the 2D planar structure formed by π‐conjugated [C4N3H6] groups. The resulting organic–inorganic hybrid crystal C4N3H6SO3NH2 exhibits a strong SHG response (2.5 × KDP), large optical anisotropy (0.233@546 nm), and blue‐violet and green fluorescence near 360 and 520 nm, respectively. This work expands the methodology for creating new NLO crystals through organic–inorganic hybridization, while also showcasing the potential of C4N3H6SO3NH2 as a multifunctional optical material.
Feasting in mussel farms fattens up snapper (Chrysophrys auratus) compared to snapper in adjacent natural habitats
Authors: Underwood Lucy H. , Mugica Maria , Jeffs Andrew G. 
Published: March 2024

AbstractThe presence of wild fish in and around aquaculture habitats is often assumed a response to food resources within these habitats, either from input feed, the presence of cultured species, and/or the assemblage of biofouling that naturally colonises aquaculture structures. The nutritional quality of the food resources consumed by wild fish in aquaculture habitats is also important in determining their nutritional condition and subsequent productivity. Few studies have investigated the nutritional quality of prey in aquaculture habitats, and these have mostly focused on fed aquaculture by tracking manufactured fish pellets into the diets of wild fish. However, in non‐fed aquaculture, the assemblage of cultured and biofouling species may also provide a nutritional benefit to fish feeding in these habitats. The Australasian snapper, Chrysophrys auratus, are commonly present as adults within coastal mussel farms in New Zealand and tend to become a resident species. This study investigated the nutritional quality of the gut contents of snapper in soft‐sediment habitats within and outside of New Zealand green‐lipped mussel farms. Total lipid, protein, carbohydrate and total calorific content were measured from the gut contents of snapper sampled from mussel farm and natural (i.e. control) habitats. Snapper in mussel farms had double the dietary intake of lipid (16% vs. 8%) from consuming lipid‐rich bivalves and barnacles which are in abundance in mussel farms. Higher lipid intake can contribute to improved nutritional condition, reproduction and growth in snapper. However, the higher dietary lipid intake of snapper in mussel farms did not increase their overall body condition (i.e. Fulton condition index). This may be due to the coarse nature of this measure, or the use of the additional lipid in more rapid somatic growth or reproductive outputs, possibilities that warrant examination through further research. Overall, this study shows for the first time the potential ecosystem benefits of shellfish aquaculture in provisioning nutritionally valuable prey for coastal fish populations.
Mesoporous coordinated polymers with single‐metal‐site iridium for efficient catalysis in propylene hydroformylation
Authors: Yao Chenfei , Xiong Wenjie , Sun Haining , Wang Xin , Zhang Zhibing , Hu Xingbang 
Published: March 2024

AbstractHeterogeneous single‐metal‐site catalysts (SMSCs) have received increasing attention due to their outstanding stability and recyclability. In this work, a novel Ir‐based SMSC was successfully constructed through the coordination polymerization between zirconium and triphenylphosphine derivatives with carboxyl functional groups for efficient propylene hydroformylation with CO. The Ir‐based SMSC reported here can achieve a turnover number of over 20,000 (being 7.3 times higher than the most effective Ir‐base catalyst to date) with 99% selectivity and 56% yield for aldehyde. Besides, it represents the first example with a higher selectivity of isobutyraldehyde than n‐butyraldehyde (i.e., n/i = 0.62) among the reported Ir‐based catalysts. The Ir‐based SMSC can be easily reused for at least 10 cycles without losing its reactivity, whereas the homogeneous monomer catalyst quickly loses its reactivity after the second cycle. Furthermore, the catalytic mechanism of Ir‐based SMSC is proposed based on reaction explorations and in situ co‐adsorption tests by the method of diffuse reflectance infrared Fourier transform spectroscopy, which has also been revealed by theoretical calculations. This work provides a novel insight into the design of SMSCs with great potential for application in the hydroformylation field.
Photo‐regulated synergistic catalysis of acid and basic sites in metal–organic framework
Authors: Wen Hui , Nian Yao , Tan Peng , Qi Hang‐Ou , Gu Chen , Yang Tao , Han You , Sun Lin‐Bing 
Published: March 2024

AbstractEnzymes have flexible structures and can modulate the multiple catalytic sites efficiently for synergistic catalysis. Inspired by enzymes, various artificial catalysts have been designed, while controllable synergistic effects in artificial catalysts have never been reported. Here, we report the first example of photo‐regulated synergistic catalyst (PRSC) and the synergistic effects between acidic and basic sites can be regulated by light. PRSCs have acidic sites on pore walls and basic sites on pendant azobenzene groups, and photo‐regulation is achieved through azobenzene isomerization. In the cascade reaction of converting benzaldehyde dimethyl acetal (BA) to benzylidenemalononitrile (BM), the PRSC shows a change of up to 33.6% in BM yield. Mechanism exploration indicates that cis azobenzene makes the catalytic system more stable. The promoted adsorption energy of the reactant malononitrile (MN) on basic sites and the activated C atom of MN that connects to methylene groups are responsible for the tunable synergistic effects of PRSCs.
Efficient construction of multi‐stimuli responsive colloidosomes for intelligent transmembrane transport
Authors: Liu Rong‐Kun , Jia Jia , Sun Qian , Zhao Hong , Wang Jie‐Xin 
Published: March 2024

AbstractThe colloidosome, as a kind of Pickering microcapsule, offers a highly functionalizable approach for encapsulation, but current studies mainly focus on shells that lack real‐time modulated permeability. Herein, a scalable spray drying method was employed to fabricate temperature/near‐infrared (NIR)/magnetic multi‐stimuli responsive colloidosomes with adjustable permeability, facilitating intelligent transmembrane transport of molecules. The colloidosomes assembled with SiO2/polydopamine/poly (N‐isopropyl acrylamide) nanoparticles can be heated from 25°C to 50°C within 5 min upon NIR exposure. The permeability of shells regulated by temperature and NIR allows for real‐time remote control. Yeast cells, as an example, are encapsulated within colloidosomes. The decomposition rate of H2O2 varies with temperature (25–45°C) and NIR intensity (0.5–1 W cm−2), which can attain a more than sixfold increase in the rate constant of pseudo‐first‐order kinetic model. Furthermore, the strategy was expanded by encapsulating doxorubicin/UiO‐66 particles, highlighting its great potential in realms of multi‐stimuli responsive colloidosomes applications.