bluuebunny/crossref_metadata_2025_split huggingface dataset:
Boron and Fluorine Co‐Doped Graphene/Few‐Walled Carbon Nanotube Composite as Highly Active Electrocatalyst for Oxygen Reduction Reaction
Authors: Raudsepp Ragle , Türk Karl‐Kalev , Zarmehri Ehsan , Joost Urmas , Rauwel Protima , Saar Rando , Mäeorg Uno , Dyck Alexander , Bron Michael , Chen Zhongming , Noda Suguru , Kruusenberg Ivar , Tammeveski Kaido 
Published: March 2024

AbstractFunctionalization of nanocarbon materials with heteroatoms is of paramount interest as doping of carbon with electron withdrawing groups results in change of electrochemical properties of the potential catalyst. Adding fluorine, as the most electronegative element into the doping process next to boron is expected to have significant effect on the design of novel nanocarbon‐based electrocatalysts. In this paper boron and fluorine co‐doped reduced graphene oxide/few‐walled carbon nanotube (BF‐rGO/FWCNT) catalysts are synthesized via simple and low‐cost direct pyrolysis method using boron trifluoride diethyl etherate (BTDE). Composition analysis confirmed that boron and fluorine have been grafted onto the carbon support. Rotating disk electrode (RDE) measurements revealed that BF‐rGO/FWCNT has remarkable electrocatalytic activity toward the oxygen reduction reaction (ORR) both in alkaline and acid media. The onset potential of the best BF‐rGO/FWCNT catalyst was 50 mV more positive in alkaline and 600 mV more positive in acidic media compared with un‐doped rGO/FWCNT. The half‐wave potential was 100 mV more positive in alkaline media and 700 mV more positive in acidic media in comparison with un‐doped rGO/FWCNT.
Infrared Laser Stark Spectroscopy of Methyl Fluoride in 4He Nanodroplets
Authors: Raston Paul L. , Douberly Gary E. 
Published: March 2024

AbstractWe measured the rotationally resolved infrared spectra of helium solvated methyl fluoride at 3 μm and 10 μm, wherein lies C−H and C−F stretching bands, respectively. The linewidths (FWHM) were found to increase with increasing vibrational energy and range from 0.002 cm−1 in the v3 band (C−F stretch) at ~1047 cm−1, to 0.65 cm−1 in the v4 band (asymmetric C−H stretch) at ~2997 cm−1. In between these two bands we observed the lower and upper components of the Fermi triad bands (ν1/2ν2/2ν5) at ~2859 and ~2961 cm−1. We carried out Stark spectroscopy on the lower band on account of its narrower linewidths (0.04 vs. 0.14 cm−1, respectively). The objective of performing Stark spectroscopy was to see if there is any evidence for a rotational linewidth dependence on the external field strength, due to a reduced difference in between methyl fluorides rotational energy gap and the roton‐gap of superfluid helium. We did not find any evidence for such an effect, which we largely attribute to the rotational energy gap not increasing significantly enough by the external field. We point to another molecule (formaldehyde) whose energy levels are predicted to show a more promising response to application of an external field.
Multi‐Resonance Thermally Activated Delayed Fluorescence Molecules for Triplet‐Triplet Annihilation Upconversion
Authors: Zhang Ming‐Yu , Li Ji‐Kun , Wang Xiao‐Ye , Huang Ling 
Published: March 2024

AbstractTriplet‐triplet annihilation upconversion (TTA‐UC) has made significant progress in recent years in several key applications, including solar energy harvesting, photocatalysis, stereoscopic 3D printing, and disease therapeutics. In TTA‐UC research, photosensitizers serve the vital function of harvesting low‐energy photons. The photophysical characteristics of photosensitizers, including absorbance, triplet state quantum yield, triplet state energy level, triplet state lifetime, etc., determine the performance of TTA‐UC. Thus, the study of photosensitizers has been a key aspect of TTA‐UC. In recent years, multi‐resonance thermally activated delayed fluorescence (MR‐TADF) molecules have received extensive attention due to their excellent photophysical properties and electroluminescent device performance. MR‐TADF molecules not only present a narrow energy gap between the singlet and triplet excited states, but also have stronger absorption and better wavelength regulation than conventional TADF molecules. Nowadays, the preliminary attempts in TTA‐UC using MR‐TADF molecules as photosensitizers have resulted in the development of green to ultraviolet, blue to ultraviolet, and even near‐infrared to blue emission. This concept will summarize the research progress of MR‐TADF molecules as photosensitizers in TTA‐UC, analyzing the challenges and giving possible solutions. Finally, we prospect the future development of MR‐TADF molecules as photosensitizers, including the molecular design as well as the possible application areas.
Evaluation of speed breeding conditions for accelerating Fusarium head blight and deoxynivalenol screening in wheat
Authors: Chhabra Bhavit , Thrasu Saijagruti , Wallace Sydney , Schoen Adam , Shahoveisi Fereshteh , Dong Yanhong , Tiwari Vijay , Rawat Nidhi 
Published: March 2024

AbstractFeeding the world's ever‐increasing population requires continuous development of high‐yielding and disease‐resistant cultivars of food crops such as wheat (Triticum aestivum L.). Speed breeding, which utilizes longer photoperiod times and higher temperatures, is a technique that accelerates plant development and is rapidly being adopted by wheat breeders across the globe to fast‐track cultivar development. Plant diseases are a major threat to crop production, and breeding for disease resistance is a major goal of crop breeders. Fusarium head blight (FHB), caused by Fusarium graminearum, is a major disease of small grain cereals, affecting their yield and quality. The aim of present work was to assess if speed breeding conditions can be used to accelerate reliable assessment of FHB severity and mycotoxin deoxynivalenol (DON) accumulation in wheat varieties. We screened a set of six spring wheat genotypes with different levels of genetic resistance (two moderately susceptible, two highly susceptible, one moderately resistant, and one resistant) for their response to FHB at 14 days after inoculation (dai) and 21 dai and DON accumulation under normal versus speed breeding conditions. FHB severity and DON accumulation were found to be highly correlated at all time points under normal and speed breeding conditions. Robust differentiation between resistant and susceptible genotypes could be achieved at 14 dai rather than the normal period of 21 dai, saving at least a week in phenotyping. Combined with the accelerated growth, flowering, and maturity under these conditions, efficient FHB screening and DON evaluation under speed breeding conditions will fast‐track development of resistant wheat varieties.
JCAD deficiency delayed liver regenerative repair through the Hippo–YAP signalling pathway
Authors: Zhang Li , Yang Yong‐Yu , Xie Li , Zhou Yuan , Zhong Zhenxing , Ding Jia , Wang Zhong‐Hua , Wang Yu‐Li , Liu Xiu‐Ping , Yu Fa‐Xing , Wu Jian 
Published: March 2024

AbstractBackground and aimsLiver regeneration retardation post partial hepatectomy (PH) is a common clinical problem after liver transplantation. Identification of key regulators in liver regeneration post PH may be beneficial for clinically improving the prognosis of patients after liver transplantation. This study aimed to clarify the function of junctional protein‐associated with coronary artery disease (JCAD) in liver regeneration post PH and to reveal the underlying mechanisms.MethodsJCAD knockout (JCAD‐KO), liver‐specific JCAD‐KO (Jcad△Hep) mice and their control group were subjected to 70% PH. RNA sequencing was conducted to unravel the related signalling pathways. Primary hepatocytes from KO mice were treated with epidermal growth factor (EGF) to evaluate DNA replication. Fluorescent ubiquitination‐based cell cycle indicator (FUCCI) live‐imaging system was used to visualise the phases of cell cycle.ResultsBoth global and liver‐specific JCAD deficiency postponed liver regeneration after PH as indicated by reduced gene expression of cell cycle transition and DNA replication. Prolonged retention in G1 phase and failure to transition over the cell cycle checkpoint in JCAD‐KO cell line was indicated by a FUCCI live‐imaging system as well as pharmacologic blockage. JCAD replenishment by adenovirus reversed the impaired DNA synthesis in JCAD‐KO primary hepatocyte in exposure to EGF, which was abrogated by a Yes‐associated protein (YAP) inhibitor, verteporfin. Mechanistically, JCAD competed with large tumour suppressor 2 (LATS2) for WWC1 interaction, leading to LATS2 inhibition and thereafter YAP activation, and enhanced expression of cell cycle‐associated genes.ConclusionJCAD deficiency led to delayed regeneration after PH as a result of blockage in cell cycle progression through the Hippo–YAP signalling pathway. These findings uncovered novel functions of JCAD and suggested a potential strategy for improving graft growth and function post liver transplantation.Key PointsJCAD deficiency leads to an impaired liver growth after PH due to cell division blockage.JCAD competes with LATS2 for WWC1 interaction, resulting in LATS2 inhibition, YAP activation and enhanced expression of cell cycle‐associated genes.Delineation of JCADHippoYAP signalling pathway would facilitate to improve prognosis of acute liver failure and graft growth in living‐donor liver transplantation.
SO‐CPP: Sailfish optimization‐based controller placement in IoT‐enabled software‐defined wireless sensor networks
Authors: Kumari Rajoriya Manisha , Gupta Chandra Prakash 
Published: March 2024

SummaryOne of the expanding network topologies that is frequently utilized to improve network development by successfully separating the control plane and data plane is software‐defined networking (SDN). In order to function inside complex sensor networks, the SDWSN system frequently relies on centralized controller logic that pulls global network information. In wireless sensor networks (WSNs), using several SDN controllers is known as a promising strategy due to reliability and performance considerations. However, using numerous controllers increases the synchronization overhead between the controllers. Consequently, it is a difficult research challenge to discover the best placement of SDN controllers to enhance the performance of a WSN, subject to the maximum number of controllers calculated based on the synchronization overhead. This research introduces a novel technique to overcome the controller placement problem (CPP) by optimizing multi‐constraints within the sensor networks. For selecting the optimal controllers and placing them in an optimal location, a novel sailfish optimization (SO) strategy is introduced that can enhance the search space and maintain optimal global values throughout the iteration. Then, node clustering is performed using the fuzzy‐C‐means (FCM) clustering technique, which can reduce energy consumption and path delay within the network. The overall latency obtained by the proposed method is about 0.51 and 0.56 ms, and a total run time of 4 ms for both single sink and multi‐sink, respectively. The proposed method is implemented in the MATLAB platform, and different performance metrics are analyzed and compared with existing techniques.
Sensory processing across eating disorders: A systematic review and meta‐analysis of self‐report inventories
Authors: Cobbaert Laurence , Hay Phillipa , Mitchell Philip B. , Roza Sabine J. , Perkes Iain 
Published: March 2024

AbstractObjectiveThis review investigated the extant literature regarding the relationship between eating disorder diagnoses and sensory processing as measured by validated and reliable self‐report inventories. Increasing evidence highlights the role of sensory processing in cognitive functions. Sensory processing is implicated in mental‐ill health, including eating disorders (ED) and body image disturbances. However, the pathophysiological underpinnings of sensory processing, encompassing exteroception and interoception, in relation to ED remain underexplored.MethodWe included studies involving participants aged 15 years or older with an eating disorder diagnosis confirmed by semi‐structured or structured interviews. We further limited inclusion to articles using validated and reliable self‐report instruments to measure sensory processing. Our meta‐analysis focused on studies using the interoceptive awareness subscale from the second version of the Eating Disorder Inventory. We used the Critical Appraisal checklist for quasi‐experimental studies to assess the quality of included articles.ResultsThere were 19 studies that met our inclusion criteria. Most studies showed moderate‐to‐high quality. Anorexia nervosa (AN) and bulimia nervosa (BN) were associated with heightened exteroception. Moreover, people with AN reported a heightened sense of taste compared to those with BN. Our meta‐analysis comprising 10 studies, 19 samples, and 6382 participants revealed that AN (binge‐purge subtype) and BN were associated with increased interoceptive difficulties compared to AN (restrictive subtype) or binge‐eating disorder.DiscussionOverall, this review emphasizes the need for a deeper investigation into sensory processing, spanning both exteroception and interoception, in relation to ED. This may prove important for individualizing person‐centered care.Public significanceHow people process internal, for example, hunger, and external, for example, taste and sensations is known to influence cognition and mental‐ill health, including ED and body image disturbances. However, the ways in which sensory processing may contribute to ED are incompletely understood. We found that individuals with AN or BN experienced heightened exteroception, while people with an eating disorder characterized by purging reported increased interoceptive difficulties. These patterns could inform the development of more personalized treatments.
Outcrossing in Caenorhabditis elegans increases in response to food limitation
Authors: Slowinski Samuel P. , Gresham Jennifer D. , Cui Eric R. , Haspel Katharine , Lively Curtis M. , Morran Levi T. 
Published: March 2024

AbstractTheory predicts that organisms should diversify their offspring when faced with a stressful environment. This prediction has received empirical support across diverse groups of organisms and stressors. For example, when encountered by Caenorhabditis elegans during early development, food limitation (a common environmental stressor) induces the nematodes to arrest in a developmental stage called dauer and to increase their propensity to outcross when they are subsequently provided with food and enabled to develop to maturity. Here we tested whether food limitation first encountered during late development/early adulthood can also induce increased outcrossing propensity in C. elegans. Previously well‐fed C. elegans increased their propensity to outcross when challenged with food limitation during the final larval stage of development and into early adulthood, relative to continuously well‐fed (control) nematodes. Our results thus support previous research demonstrating that the stress of food limitation can induce increased outcrossing propensity in C. elegans. Furthermore, our results expand on previous work by showing that food limitation can still increase outcrossing propensity even when it is not encountered until late development, and this can occur independently of the developmental and gene expression changes associated with dauer.
Assessing the diversity and determinants of health‐related quality of life measures in patients with acute heart failure
Authors: Patil Dhrumil , Tang Hsin‐Ju , Kuo Fang‐Hsiu , Toh Han Siong , Yang I‐Ning , Chang Wei‐Ting , Lee Mei‐Chuan , Chung Kai‐Ning , Huang Chi‐Ya , Hsu Wan‐Hsuan , Chang Ting‐Chia , Shih Jhih‐Yuan , Liao Chia‐Te 
Published: March 2024

AbstractAimsHeart failure with reduced ejection fraction (HFrEF) significantly impacts health‐related quality of life (HR‐QoL). Existing HR‐QoL questionnaires can show inconsistencies, potentially misrepresenting patient self‐reports. This study examines the variation in HR‐QoL measurement tools for HFrEF patients, identifying related determinants.Methods and resultsWe retrospectively analysed 134 hospitalized patients with acute decompensated HFrEF at a Taiwanese tertiary centre's Heart Failure Post‐Acute‐Care (HF‐PAC) programme. Participants completed the EuroQol‐5 dimension (EQ‐5D) questionnaire, the EQ‐5D visual analogue scale (VAS), and the Minnesota Living with Heart Failure Questionnaire (MLHFQ). Utility values were obtained from the EQ‐5D questionnaire. Demographic features were depicted using descriptive statistics, while multivariate regression was used to ascertain relationships between HR‐QoL measurements and determinants. Average scores for EQ‐5D, MLHFQ, EQ‐5D utility, and VAS were 6.1 ± 1.6, 21.8 ± 21.3, 81.7 ± 27.0, and 59.5 ± 14.6, respectively. Significant correlations were observed among the three tools. The New York Heart Association functional class showed a notable association with all tool scores. Other associations encompassed EQ‐5D with coronary artery disease, mineralocorticoid receptor antagonists, and the 6 min walk test; EQ‐5D VAS with chronic kidney disease; and MLHFQ with age.ConclusionsThis study illuminates the variance in HR‐QoL measurement tools for Taiwanese HFrEF patients. Using a range of these tools is beneficial in unveiling diverse determinants and approaching comprehensive patient‐centred care. However, for a more precise HR‐QoL assessment in Taiwanese HFrEF patients, recalibrating the EQ‐5D‐derived utility scores might be necessary, emphasizing the importance of patient‐specific considerations within the HF‐PAC programme.
Ru(II)‐Nitrophenylhydrazine/Chlorophenylhydrazine Complexes: Nanoarchitectonics, Biological Evaluation and In silico Study
Authors: Eichhorn Thomas , Đošić Marko , Dimić Dušan , Morgan Ibrahim , Milenković Dejan , Rennert Robert , Amić Ana , Marković Zoran , Kaluđerović Goran N. , Dimitrić Marković Jasmina 
Published: March 2024

AbstractRu(II)‐arene compounds are being investigated as anticancer agents due to the biocompatibility of ruthenium and their structural diversity. Two newly synthesized Ru(II) complexes, [RuCl(η6‐p‐cymene)(3‐DNPH)] (chlorido(η6‐p‐cymene)(3‐nitrophenylhydrazine‐k2N,N′)ruthenium(II)) (1) and [RuCl(η6‐p‐cymene)(3‐CNPH)] (chlorido(3‐chlorophenylhydrazine‐k2N,N′)(η6‐p‐cymene)ruthenium(II)) (2), are experimentally (IR, NMR) and theoretically (B3LYP/6‐31+G(d,p)(H,C,N,Cl)/LanL2DZ(Ru)) characterized. Experimental and theoretical values of 1H and 13C chemical shifts and position of the most intense vibrational bands showed high correlation coefficients and low mean absolute errors, proving the predicted structure and applicability of the selected level of theory. Cell viability studies performed on MDA‐MB‐468, BT‐474, and PC3 cells using MTT and CV assay indicated the activity of the second complex similar to the activity of cisplatin towards BT‐474 breast cancer cells. The spectrofluorimetric measurements of Bovine Serum Albumin showed the binding process‘s spontaneity of complexes and protein, with a binding energy of around −30 kJ mol−1. Detailed molecular docking analysis allowed the elucidation of the binding mechanism through specific intermolecular interactions. Both compounds showed a higher affinity towards BSA than naproxen and cisplatin. Molecular docking simulations proved the spontaneity of the complexes binding to DNA. Based on these promising results, further biological examinations of these compounds are advised.
Uranyl‐Organic Framework as Hydrogen Atom Transfer Catalyst for Visible‐Light‐Driven Heterogeneous Hydroacylation of Azodicarboxylates
Authors: Chen Lei , Tan Ke‐Xin , Zheng Zhi‐Jian , Lin Xiao‐Ling , Ming Bang‐Ming , Zhang Zhi‐Bin , Yang Guo‐Ping 
Published: March 2024

AbstractThe direct C−H to C−N bond conversion at room temperature using heterogeneous visible‐light catalysts is both interesting and challenging. Herein, we disclosed visible‐light‐promoted hydroacylation of azodicarboxylates using uranyl‐organic framework [UO2(OH)(cpt)]n (Ucpt, Hcpt=4‐(4′‐carboxyphenyl)‐1,2,4‐triazole) as an efficient heterogeneous hydrogen atom transfer photocatalyst. In this procedure, diverse benzaldehydes are compatible using dimethyl carbonate (DMC) as a green solvent at room temperature, achieving direct conversion of C−H to C−N bond with excellent yields (up to 99%). The key to excellent catalytic activity lies in the fact that the coordination of the conjugated ligand changes the HOMO energy level of Ucpt, resulting in more active sites and longer‐lived photo excitons. Simultaneously, this heterogeneous photocatalyst can be easily separated and reused for seven successive cycles and maintain high catalytic activity, showing outstanding sustainability and recyclability.
Molecular Networking‐Guided Discovery of Kyonggic Acids in Massilia spp.
Authors: Steinmetz Till , Lindig Anton , Lütz Stephan , Nett Markus 
Published: March 2024

AbstractIn recent years, bacteria of the genus Massilia have been identified as promising sources of bioactive natural products. In this study, we used mass spectrometry (MS)‐based molecular networking for the first comprehensive analysis of the secondary metabolome of these microorganisms. Annotation of the detected metabolite clusters with a mass fragmentation database revealed several compounds not previously known to be produced by Massilia species. To secure sufficient material for further structural analyses as well as biological testing, we selected the most promising producer strains from our molecular networking analysis and subjected them to larger‐scale cultivation. Following extraction and UV‐directed isolation, we obtained five metabolites in milligram quantities. In addition to a cyclic dipeptide, we elucidated the structures of four acyl amino acids that are related to thalassotalic acid C from the marine bacterium Thalassotalea sp. The Massilia‐derived kyonggic acids were found to inhibit the enzyme tyrosinase, which is involved in melanin biosynthesis influencing skin and hair pigmentation. This study illustrates the value of combining spectroscopic and computational tools in natural product discovery in order to detect and guide the isolation of previously overlooked bioactive compounds.
Visible‐Light‐Induced Metal‐Free Three‐Component Amidoheteroarylation of Alkenes to Synthesize β‐(Hetero)arylethylamines
Authors: Feng Qiange , Wang He , Liu Yang , Wei Lin , Sun Jing , Wang Xin , Sun Ran , Wang Yujia , Li Lei 
Published: March 2024

AbstractHerein, visible‐light‐induced metal‐free three‐component amidoheteroarylation of alkenes with quinoxalin‐2(1H)‐ones and N‐sulfonylaminopyridinium salts is developed. This protocol involves a radical relay process in which the N‐centered radicals undergo chemoselective addition to alkenes to form an alkyl radical that selectively combines with heteroarenes, leading to the formation of C−C and C−N bonds in one step under mild reaction conditions. The involved high efficiency and selectivity, wide substrate scope, and excellent functional‐group compatibility demonstrate the practicability of the developed protocol.
Double Winding Vine‐Shaped Biphenyl with Molecular Asymmetry. Synthesis, Structure, and Properties
Authors: Mori Atsunori , Maruka Aruto , Tabuchi Kohei , Okano Kentaro , Horie Masaki 
Published: March 2024

AbstractA biphenyl derivative in which two benzene rings are strapped with two chains is prepared. The synthesized product shows molecular asymmetry, which was confirmed by HPLC analysis with chiral column and named as winding vine‐shaped biphenyl. The synthesis of such vine shaped molecule was performed by ring‐closing metathesis or alternatively by annulation with nosylated ethylenediamine. The structure of the obtained product was confirmed by X‐ray crystallographic analysis. The absolute configuration of the molecular asymmetry was assigned after leading to the corresponding camphor sulfonamide through denosylation and re‐amidation process.