bluuebunny/crossref_metadata_2025_split huggingface dataset:
(199) The Impact of Body Weight on Sexual Function on Woman
Authors: Kong M 
Published: March 2024

Abstract

Introduction
Female sexual dysfunction (FSD) is a complex disorder which has an impact on women regardless of their age and race, and related to a variety of biological, psychological, and social determinants. Sexuality impact quality of life through effects on the emotional and psychological health of a woman.

Objective
The purpose of this study is to investigate the impact of body weight on sexual function in women. The associations of sexual function with demographic and clinical variables were evaluated.

Methods
We performed a cross-sectional study of comparing female sexual function index in normal weight and obese women. Patients with a diagnosis of benign gynecologic disease who admitted for gynecological surgery at our institution from January 2012 to December 2015 were evaluated. Total 349 women were enrolled in this study and complete the Female Sexual Function Index (FSFI) questionnaires. 264 women in normal weight group (body mass index, BMI &lt;25 kg/m2) and 85 women in obese group (BMI ≥ 25 kg/m2) participated. Risk factors for female sexual function were examined using logistic regression models. We used a two-sample t-test and chi-square test for the categorical variables. Mann-Whitney U test for continuous variables and Fisher’s exact test for categorical variables

Results
The mean BMIs were 21.6±1.95 (mean±SD, kg/m2) in normal weight group and 27.6±2.56 in obese group (p &lt; 0.001). There were also significant differences in age (mean±SD, 43.3±10.17 vs. 46.9±8.70 years, p = 0.002), parity (mean±SD, 1.5±0.99 vs. 1.9±1.19, p = 0.001), vaginal parity (mean±SD, 1.1±1.06 vs. 1.5±1.38, p = 0.043), marriage status (80.7% vs. 89.4%, p = 0.046) and hypertension (6.1% vs. 15.3%, p = 0.012). There were no differences in postmenopausal status, prior history of pelvic reconstructive surgery and urinary symptoms. In comparison of FSFI scores, there were significant differences in total score and all 6 domain scores (Desire, Arousal, Lubrication, Orgasm, Satisfaction and pain) between normal weight and obese group (p &lt; 0.001). In the multiple logistic regression model for female sexual dysfunction, BMI, menopause and marriage were significantly different.

Conclusions
This study suggests that obesity has some impact on female sexual function. And menopause and marriage status are also associated with female sexual dysfunction. As obese woman population is increasing, the further study will be needed in a larger subgroup of women with long-term follow up period

Disclosure
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(211) Study of Postpartum Sexuality in Tunisian Women
Authors: Naouraz D , Rim B , Imen B 
Published: March 2024

Abstract

Introduction
Childbirth is a period of imbalance responsible for multidimensional changes that can influence sexual life. The aim of the study is to study the sexuality of women after childbirth, to specify the factors that influence it and to analyze the aspects of sexual dysfunction that accompany this period.

Objective
Evaluate women's postpartum experience and sexuality, while identifying difficulties that may arise during this high-risk period. Assess women's satisfaction with the information they receive on sexuality during perinatal and post-partum consultations.

Methods
This was a descriptive study that was spread over a period of 6 months from July 1, 2021 to December 31, 2021.200 women who gave birth in the six months preceding the study were included in the study. Two self-questionnaires were sent by internet through a social network.

Results
Our population of 200 women had a mean age of 34.3 years and the majority of women were urban, and university-educated. fourty-five per cent were second gestations and 58,5% of them had given birth by cesarean section. The average FSFI score in our sample was 21,99/36 postpartum, which implied sexual dysfunction in 72% of the women in our population. The delay in resumption of sexual activity was later in primiparous women, women with vaginal delivery and breastfeeding women. There was an association between instrumental delivery and the degree of dyspareunia. No difference was found in sexuality between vaginal delivery and caesarean section, nor for scheduled or emergency caesarean section. All areas of female sexual function were affected with mainly pain associated with sexuality. Some factors influencing the resumption of sexual activity could be identified such as breastfeeding, the presence of perineal tears, lack of lubrication and fear of becoming pregnant.

Conclusions
The majority of women in our population had sexual dysfunction in the postpartum period. The different areas of female sexual function were affected and correlated with the different parameters related to childbirth and the postpartum period.

Disclosure
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(215) Investigating if Hormonal Dysfunctions are Risk Factors in Men Complaining of Premature Ejaculation
Authors: Habous M , Nelson C , Mulhall J 
Published: March 2024

Abstract

Introduction
Most epidemiological studies suggest that premature ejaculation (PE), also referred to as early ejaculation and rapid ejaculation, may be the most common male sexual disorder. The exact etiology of PE is unknown. Psychological/behavioristic and biogenic etiologies have been proposed.

Objective
Initial reports indicate that there are hormone differences between men with primary (lifelong) and secondary (acquired) PE. This study was designed to investigate hormone profiles of these two subgroups.

Methods
Men who presented to our outpatient clinic with PE were enrolled in this study. The diagnosis and classification (primary or secondary) of PE was based on patient medical and sexual history according to guidelines of international society of sexual medicine (ISSM) and European association of urology (EAU). Complete physical examination was done and we measured thyroid stimulating hormone (TSH), testosterone (T), and prolactin (P) for all patients. Statistical analyses included descriptive statistics and independent-measures t-test for univariate analyses. Analysis of covariance was used for multivariable analyses.

Results
506 men were included in this analysis. The average age of these men was 44±12 years old and the mean body mass index (BMI) was 26.7±5.5. The mean levels of T, TSH, and P for the entire sample was 4.38±1.69, 2.31±3.56, and 10.56±11.04, respectively. There were 267 men in the primary PE group and 239 men in the secondary PE group. The men with primary PE were significantly younger than those with secondary PE (37±11 vs. 52±12, p=0.001). There were no significant differences in BMI between the groups. On univariate analyses, there was no differences between the primary PE and secondary PE groups in T (4.39±1.66 vs. 4.38±1.84, p=0.94), TSH (2.31±4.89 vs. 2.20±2.07, p=0.76), and P (10.65±8.13 vs. 10.46±13.46, p=0.86). When controlling for age in multivariable analyses, there continued to be no differences between the two groups (p values ranging from p=0.56 to 0.81).

Conclusions
hormonal profile including T, TSH and P seem to be in the normal range in men with PE and there is no statistical difference in these hormones between primary and secondary PE

Disclosure
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(262) Salvage Penile Prosthetic Surgery, Unique Surgical Technique. Institutional Experience
Authors: Kattan S , Almalki A , Alhumaid S 
Published: March 2024

Abstract

Introduction
`-Penile prosthesis surgery represents the end-stage treatment for erectile dysfunction. It is conventionally used only in cases of erectile dysfunction refractory to pharmacological treatments. -Penile prothesis surgery is associated with a high satisfaction rate and a low complication profile. However, it must be appreciated that the complications of surgery can have devastating consequences on a patient's quality of life and satisfaction and include infection, prosthesis malfunction, penile corporal perforation and penile length loss. -This study discusses the diagnosis and management of infected penile prosthesis with highlighting special intra-operative surgical technique that might be a valuable step in Salvage penile prosthetic surgery

Objective
Since its introduction in 1996 Mulcahy salvage has significantly improved outcomes for the removal and replacement of infected penile prostheses. Long-term follow up data of Mulcahy salvage show an infection-free rate of 82%. In our study we evaluated the Salvage Penile Prosthetic Surgery Cases done in our tertiary institution since (2000 up to date) and introduce the unique surgical technique that resulted in reduction the re-infetion rate.

Methods
This is a retrospective, institutional review

Results
total of 13 Salvage penile prosthetic surgeries done in our tertiary center since between 2000 and 2023 out of them only one case developed reinfection and ended with penile prosthesis removal. Therefor, the rate of re-infection is 8% comparing with latest successe rate of Mulcahy technique (18%) We applied surgical step intra- operative that might be the underling reason of decreasing the the reinfection rate that will be presented in details.

Conclusions
This retrospective analysis of salvage procedures and replacement of infected penile prosthesis with malleable prosthesis shows a high infection-free rate.

Disclosure
No.
Humoral immunogenicity of primary yellow fever vaccination in infants and children: a systematic review, meta-analysis and meta-regression
Authors: Ferrara Pietro , Losa Lorenzo , Mantovani Lorenzo G , Ambrosioni Juan , Agüero Fernando 
Published: March 2024

Abstract

Background
Vaccination plays a critical role in mitigating the burden associated with yellow fever (YF). However, there is a lack of comprehensive evidence on the humoral response to primary vaccination in the paediatric population, with several questions debated, including the response when the vaccine is administered at early ages, the effect of co-administration with other vaccines, the duration of immunity and the use of fractional doses, among others. This study summarizes the existing evidence regarding the humoral response to primary YF vaccination in infants and children.

Methods
Studies on the humoral response to primary YF vaccination in children aged 12 years or younger were reviewed. The humoral vaccine response rate (VRR), i.e. the proportion of children who tested positive for vaccine-induced YF-specific neutralizing antibodies, was pooled through random-effects meta-analysis and categorized based on the time elapsed since vaccination. Subgroup, meta-regression and sensitivity analyses were performed.

Results
A total of 33 articles met the inclusion criteria, with all but one conducted in countries where YF is endemic. A total of 14 028 infants and children entered this systematic review. Within three months following vaccination, the pooled VRR was 91.9% (95% CI 89.8–93.9). A lower VRR was observed with the 17DD vaccine at the meta-regression analysis. No significant differences in immunogenicity outcomes were observed based on age, administration route, co-administration with other vaccines, or fractional dosing. Results also indicate a decline in VRR over time.

Conclusions
Primary YF vaccination effectively provides humoral immunity in paediatric population. However, humoral response declines over time, and this decline is observable after the first 18 months following vaccination. A differential response according to the vaccine substrain was also observed. This research has valuable implications for stimulating further research on the primary YF vaccination in infants and children, as well as for informing future policies.
Elder abuse
Authors: Crome Peter , Arora Amit , Arora Anmol 
Published: March 2024

Abstract
Elder abuse is still under-reported and under-recognized in many cases. This chapter discusses definitions of elder abuse and key issues related to this serious problem including barriers that prevent vulnerable older people seeking help. This chapter also examines the role of health professionals in early identification and management of elder abuse. It explores some of the indicators of elder abuse that can help non-clinicians identify older people at risk of harm. This chapter also describes the current procedure for management of elder abuse in England and some other countries and covers some information about laws relevant to elder abuse. Support services and non-governmental organizations are an important resource for helping victims of elder abuse and their role is described briefly in this chapter.
Never Die Alone: Donald Goines, Black Iconicity, and Série Noire
Authors: Manditch-Prottas Zachary 
Published: March 2024

Abstract
Depending on who you ask, Donald Goines is a pioneer of Black popular fiction or a purveyor of shoddy pulp. This duality is illustrative of an impasse between American intelligentsia and Goines’s folk readership. Goines wrote sixteen novels between 1971-74 that have remained in print for sixty years with sales in the millions. Yet Goines remains an understudied American author and unacknowledged in the transnational reach of his writing. This essay offers the first scholarly consideration of Donald Goines’s status as a transnational author. Specifically, I analyze Goines’s promotion and reception in America and France. I will focus on Goines’s two prime distributors: Holloway House Publishing, which debuted Goines’s novels as the premier works of its Black Experience Books imprint in the early 1970s, and Gallimard Publishing, which translated Goines’s work into French as part of its famed crime fiction imprint, Série Noire, in the 1990s and early 2000s. This transnational comparative approach draws on three archives: Holloway House’s promotional materials that endorse Goines as the unprecedented authentic authorial voice of American Blackness, an unexamined element of the Holloway House archive that promotes Goines as an internationally revered author, and the nearly unacknowledged materials of Goines’s French publisher Gallimard that situate Goines as an author of American noir. Holloway House’s shift in promotional tactics and Série Noire’s prioritization of Goines as an author of American noir has two telling implications. First, it exposes how the racially essentialist logic of Holloway House linked authorial experience and literary fiction to promote the “authentic” Black experience as tethered to criminality. Second, it situates Goines in an internationally recognized US tradition of crime fiction in a way still largely unacknowledged in the United States.
Reconstructing the baryonic acoustic oscillations in the presence of photo-z uncertainties
Authors: Chan Kwan Chuen , Lu Guoyuan , Wang Xin 
Published: March 2024

ABSTRACT
The reconstruction method has been widely employed to improve the baryon acoustic oscillations (BAO) measurement in spectroscopic survey data analysis. In this study, we explore the reconstruction of the BAO signals in the realm of photometric data. By adapting the Zel’dovich reconstruction technique, we develop a formalism to reconstruct the transverse BAO in the presence of photo-z uncertainties under the plane-parallel approximation. We access the performance of the BAO reconstruction through comoving N-body simulations. The transverse reconstruction potential can be derived by solving a 2D potential equation, with the surface density and the radial potential contribution acting as the source terms. The solution is predominantly determined by the surface density. As is evident in dense samples, such as the matter field, the transverse BAO reconstruction can enhance both the strength of the BAO signals and their cross correlation with the initial conditions. At z = 0, the cross-correlation is increased by a factor of 1.2 at $k_\perp = 0.2 \, \mathrm{Mpc}^{-1}h$ and 1.4 at $k_\perp = 0.3 \, \mathrm{Mpc}^{-1}h$, respectively. We contrast the 2D potential results with the 3D Poisson equation solution, wherein we directly solve the potential equation using the position in photo-z space, and find good agreement. Additionally, we examine the impact of various conditions, such as the smoothing scales and the level of photo-z uncertainties, on the reconstruction results. We envision the straightforward application of this method to survey data.
Distinct function of Chlamydomonas CTRA-CTR transporters in Cu assimilation and intracellular mobilization
Authors: Strenkert Daniela , Schmollinger Stefan , Paruthiyil Srinand , Brown Bonnie C , Green Sydnee , Shafer Catherine M , Salomé Patrice , Nelson Hosea , Blaby-Haas Crysten E , Moseley Jeffrey L , Merchant Sabeeha S 
Published: March 2024

Abstract

Successful acclimation to copper (Cu) deficiency involves a fine balance between Cu import and export. In the green alga Chlamydomonas reinhardtii, Cu import is dependent on a transcription factor, Copper Response Regulator 1 (CRR1), responsible for activating genes in Cu-deficient cells. Among CRR1 target genes are two Cu transporters belonging to the CTR/COPT gene family (CTR1 and CTR2) and a related soluble protein (CTR3). The ancestor of these green algal proteins was likely acquired from an ancient chytrid and contained conserved cysteine-rich domains (named the CTR-associated domains, CTRA) that are predicted to be involved in Cu acquisition. We show by reverse genetics that Chlamydomonas CTR1 and CTR2 are canonical Cu importers albeit with distinct affinities, while loss of CTR3 did not result in an observable phenotype under the conditions tested. Mutation of CTR1, but not CTR2, recapitulates the poor growth of crr1 in Cu-deficient medium, consistent with a dominant role for CTR1 in high-affinity Cu(I) uptake. On the other hand, the overaccumulation of Cu(I) (20 times the quota) in zinc (Zn) deficiency depends on CRR1 and both CTR1 and CTR2. CRR1-dependent activation of CTR gene expression needed for Cu over-accumulation can be bypassed by the provision of excess Cu in the growth medium. Over-accumulated Cu is sequestered into the acidocalcisome but can become remobilized by restoring Zn nutrition. This mobilization is also CRR1-dependent, and requires activation of CTR2 expression, again distinguishing CTR2 from CTR1 and consistent with the lower substrate affinity of CTR2.

One sentence summary
Regulation of Cu uptake and sequestration by members of the CTR family of proteins in Chlamydomonas.
Origin, evolution, and maintenance of gene-strand bias in bacteria
Authors: Atre Malhar , Joshi Bharat , Babu Jebin , Sawant Shabduli , Sharma Shreya , Sankar T Sabari 
Published: March 2024

Abstract
Gene-strand bias is a characteristic feature of bacterial genome organization wherein genes are preferentially encoded on the leading strand of replication, promoting co-orientation of replication and transcription. This co-orientation bias has evolved to protect gene essentiality, expression, and genomic stability from the harmful effects of head-on replication-transcription collisions. However, the origin, variation, and maintenance of gene-strand bias remain elusive. Here, we reveal that the frequency of inversions that alter gene orientation exhibits large variation across bacterial populations and negatively correlates with gene-strand bias. The density, distance, and distribution of inverted repeats show a similar negative relationship with gene-strand bias explaining the heterogeneity in inversions. Importantly, these observations are broadly evident across the entire bacterial kingdom uncovering inversions and inverted repeats as primary factors underlying the variation in gene-strand bias and its maintenance. The distinct catalytic subunits of replicative DNA polymerase have co-evolved with gene-strand bias, suggesting a close link between replication and the origin of gene-strand bias. Congruently, inversion frequencies and inverted repeats vary among bacteria with different DNA polymerases. In summary, we propose that the nature of replication determines the fitness cost of replication-transcription collisions, establishing a selection gradient on gene-strand bias by fine-tuning DNA sequence repeats and, thereby, gene inversions.
Nonspecific phospholipases C3 and C4 interact with PIN-FORMED2 to regulate growth and tropic responses in Arabidopsis
Authors: Li Teng , Zhang Shujuan , Yao Shuaibing , Li Xuebing , Jia Qianru , Yuan Jingya , Zhang Wenhua , Wang Xuemin , Zhang Qun 
Published: March 2024

Abstract
The dynamic changes in membrane phospholipids affect membrane biophysical properties and cell signaling, thereby influencing numerous biological processes. Nonspecific phospholipase C (NPC) enzymes hydrolyze common phospholipids to release diacylglycerol (DAG), which is converted to phosphatidic acid (PA) and other lipids. In this study, 2 Arabidopsis (Arabidopsis thaliana) tandemly arrayed genes, NPC3 and NPC4, were identified as critical factors modulating auxin-controlled plant growth and tropic responses. Moreover, NPC3 and NPC4 were shown to interact with the auxin efflux transporter PIN-FORMED2 (PIN2). The loss of NPC3 and NPC4 enhanced the endocytosis and vacuolar degradation of PIN2, which disrupted auxin gradients and slowed gravitropic and halotropic responses. Furthermore, auxin-triggered activation of NPC3 and NPC4 is required for the asymmetric PA distribution that controls PIN2 trafficking dynamics and auxin-dependent tropic responses. Collectively, our study reveals an NPC-derived PA signaling pathway in Arabidopsis auxin fluxes that is essential for fine-tuning the balance between root growth and environmental responses.
Macrophage activation syndrome in patients with systemic juvenile idiopathic arthritis on anti-interleukin-1 or -6 therapy
Authors: Ulu Kadir , Aliyev Emil , Kılıç Könte Elif , Tanatar Ayşe , Türkmen Şeyma , Doğantan Şeyda , Kızıldağ Zehra , Kasap Demir Belde , Gezgin Yıldırım Deniz , Otar Yener Gülçin , Öztürk Kübra , Baba Özge , Açarı Ceyhun , Kılbaş Gülşah , Taşkın Sema Nur , Haşlak Fatih , Çağlayan Şengül , Bağlan Esra , Dundar Hatice Adıgüzel , Başaran Özge , Barut Kenan , Karadağ Şerife Gül , Coşkuner Taner , Sönmez Hafize Emine , Yüksel Selçuk , Kalyoncu Mukaddes , Bakkaloğlu Sevcan A , Ünsal Erbil , Paç Kısaarslan Ayşenur , Bilginer Yelda , Aktay Ayaz Nuray , Kasapçopur Özgür , Özen Seza , Sözeri Betül 
Published: March 2024

Abstract

Objectives
The aim of this study is to investigate the effect of anti-interleukin (IL)-1/-6 biologics on systemic juvenile idiopathic arthritis (sJIA)-associated macrophage activation syndrome (MAS).

Methods
Demographic, clinical and laboratory data of patients followed up with a diagnosis of sJIA-associated MAS assessed from sixteen paediatric rheumatology centres across the country. The clinical and laboratory features of MAS developing while on biological drugs were compared with those without this treatment.

Results
One hundred and sixty-two patients were included in the study. Forty-five of the MAS events were detected under the effect of anti-IL-1/-6 biologics, while the patients experiencing the remaining 155 events have not received biological treatment in the last three months. Platelet count [128 (72–232) vs 199 (130–371) 109/l], ferritin level on admission [1107 (676–2050) vs 2863 (1193–9562) ng/ml], C-reactive protein level [15.4 (2.9–56) vs 90 (32–160) mg/l], erythrocyte sedimentation rate [13 (3–36) vs 43.5 (13–77) mm/h] and fever duration [5 (4–7.5) vs 10 (7–14.3) days] were found lower in the group under the impact of anti-IL-1/-6 biologics. Among patients treated with biologics, 26.6% did not meet the published 2016 MAS classification criteria at presentation. The rates of hepatomegaly and splenomegaly were relatively lower in the canakinumab-treated group when compared with those receiving other biologicals or to patients, not on biologicals.

Conclusion
Anti-IL-1/-6 therapies can mask the clinical and laboratory features of MAS, and proposed guidelines for MAS classification criteria may not be met.