bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gallbladder carcinosarcoma with a poor prognosis: A case report
Authors: Dai Yi , Meng Min , Luo Qi-Zhi , Liu Yuan-Jun , Xiao Fan , Wang Chun-Hua 
Published: April 2024

BACKGROUND
Carcinosarcoma of the gallbladder is a rare malignant tumor with a very poor prognosis. To date, only approximately 100 patients have been reported in the English literature. The prognosis of this tumor type is poor, the preoperative diagnosis is difficult, and there is a possibility of a misdiagnosis. We present an unsuccessful case of carcinosarcoma of the gallbladder with a preoperative misdiagnosis and rapid early postoperative recurrence. Therefore, we have a deeper understanding of the poor prognosis of gallbladder carcinosarcoma (GBC) patients.
CASE SUMMARY
The patient is a 65-year-old male. He was admitted to the hospital because of right upper abdomen distending pain and discomfort for half a month. Abdominal magnetic resonance imaging revealed a polycystic mass in the right lobe of the liver and the fossa of the gallbladder. After admission, the patient was diagnosed with a liver abscess, which was treated by abscess puncture drainage. Obviously, this treatment was unsuccessful. Hepatectomy and cholecystectomy were performed one month after the puncture. Postoperative pathologic examination revealed carcinosarcoma of the gallbladder, and the resected specimen contained two tumor components. One month after surgery, the patient's tumor recurred in situ and started to compress the duodenum, resulting in duodenal obstruction and bleeding. The treatment was not effective. The patient died of gastrointestinal hemorrhage and hypovolemic shock.
CONCLUSION
Carcinosarcoma of the gallbladder is a rare malignant tumor that is easily misdiagnosed preoperatively and has a poor prognosis.
Moyamoya syndrome may result from psoriasis: Four case reports
Authors: Chen Zhi-Ying , Yu Xiao-Qin , Xiang Yuan-Yuan , Liu Ling-Hua , Yin Xiao-Ping 
Published: April 2024

BACKGROUND
Moyamoya syndrome (MMS) is a group of diseases that involves more than one underlying disease and is accompanied by moyamoya vascular phenomena. Psoriasis is a chronic immune skin disease closely linked to high blood pressure and heart disease. However, psoriasis-related MMS has not been reported.
CASE SUMMARY
We collected data on patients with stroke due to MMS between January 2017 and December 2019 and identified four cases of psoriasis. Case histories, imaging, and hematological data were collected. The average age of the initial stroke onset was 58.25 ± 11.52 years; three cases of hemorrhagic and one case of ischemic stroke were included. The average duration from psoriasis confirmation to the initial MMS-mediated stroke onset was 17 ± 3.56 years. All MMS-related stenoses involved the bilateral cerebral arteries: Suzuki grade III in one case, grade IV in two cases, and grade V in one case. Abnormally elevated plasma interleukin-6 levels were observed in four patients. Two patients had abnormally elevated immunoglobulin E levels, and two had thrombocytosis. All four patients received medication instead of surgery. With an average follow-up time of 2 years, two causing transient ischemic attacks occurred in two patients, and no hemorrhagic events occurred.
CONCLUSION
Psoriasis may be a potential risk factor for MMS. Patients with psoriasis should be screened for MMS when they present with neurological symptoms.
Can we triumph over locally advanced cervical cancer with colossal para-aortic lymph nodes? A case report
Authors: Alzibdeh Abdulla , Mohamad Issa , Wahbeh Lina , Abuhijlih Ramiz , Abuhijla Fawzi 
Published: April 2024

BACKGROUND
Para-aortic lymph nodes (PALNs) are common sites for the regional spread of cervical squamous cell carcinoma (SCC).
CASE SUMMARY
We report the case of a 36-year-old woman who presented with cervical SCC with multiple bulky PALNs, largest measured 4.5 cm × 5 cm × 10 cm. The patient was treated with radical intent with definitive chemoradiation using sequential dose-escalated adaptive radiotherapy, followed by maintenance chemotherapy. The patient achieved a complete response; she has been doing well since the completion of treatment with no evidence of the disease for 2 years.
CONCLUSION
Regardless of the size of PALN metastases of cervical carcinoma origin, it is still treatable (with radical intent) via concurrent chemoradiation. Adaptive radiotherapy allows dose escalation with minimal toxicity.
Positive affect during adolescence and health and well-being in adulthood: An outcome-wide longitudinal approach
Authors: Kim Eric S. , Wilkinson Renae , Okuzono Sakurako S. , Chen Ying , Shiba Koichiro , Cowden Richard G. , VanderWeele Tyler J. 
Published: April 2024

Background
Several intergovernmental organizations, including the World Health Organization and United Nations, are urging countries to use well-being indicators for policymaking. This trend, coupled with increasing recognition that positive affect is beneficial for health/well-being, opens new avenues for intervening on positive affect to improve outcomes. However, it remains unclear if positive affect in adolescence shapes health/well-being in adulthood. We examined if increases in positive affect during adolescence were associated with better health/well-being in adulthood across 41 outcomes.

Methods and findings
We conducted a longitudinal cohort study using data from Add Health—a prospective and nationally representative cohort of community-dwelling U.S. adolescents. Using regression models, we evaluated if increases in positive affect over 1 year (between Wave I; 1994 to 1995 and Wave II; 1995 to 1996) were associated with better health/well-being 11.37 years later (in Wave IV; 2008; N = 11,040) or 20.64 years later (in Wave V; 2016 to 2018; N = 9,003). Participants were aged 15.28 years at study onset, and aged 28.17 or 37.20 years—during the final assessment. Participants with the highest (versus lowest) positive affect had better outcomes on 3 (of 13) physical health outcomes (e.g., higher cognition (β = 0·12, 95% CI = 0·05, 0·19, p = 0.002)), 3 (of 9) health behavior outcomes (e.g., lower physical inactivity (RR = 0·80, CI = 0·66, 0·98, p = 0.029)), 6 (of 7) mental health outcomes (e.g., lower anxiety (RR = 0·81, CI = 0·71, 0·93, p = 0.003)), 2 (of 3) psychological well-being (e.g., higher optimism (β = 0·20, 95% CI = 0·12, 0·28, p < 0.001)), 4 (of 7) social outcomes (e.g., lower loneliness (β = −0·09, 95% CI = −0·16, −0·02, p = 0.015)), and 1 (of 2) civic/prosocial outcomes (e.g., more voting (RR = 1·25, 95% CI = 1·16, 1·36, p < 0.001)). Study limitations include potential unmeasured confounding and reverse causality.

Conclusions
Enhanced positive affect during adolescence is linked with a range of improved health/well-being outcomes in adulthood. These findings suggest the promise of testing scalable positive affect interventions and policies to more definitively assess their impact on outcomes.
Association between illness perception and social alienation among maintenance hemodialysis patients: The mediating role of fear of progression
Authors: Zhu Beisha , Wu Hang , Lv Siyu , Xu Yulan 
Published: April 2024

Purpose
This study aimed to investigate the mediating role of fear of progression on illness perception and social alienation among maintenance hemodialysis (MHD) patients.

Background
MHD is frequently accompanied by increased pain and complications such as itchy skin, chronic fatigue, and muscle spasms. Cardiovascular disease rates are also elevated among MHD patients, which can heighten their anxiety regarding prognosis and treatment discomfort. This chronic fear may severely impact social functioning, leading patients to withdraw from interpersonal interactions and experience heightened helplessness and loneliness. Further investigation is necessary to understand the factors behind the high level of social alienation in MHD patients and their underlying mechanisms.

Design
A cross-sectional study guided by the STROBE.

Methods
A convenience sample of 230 MHD patients were enrolled from January to May 2023. Data including demographic and clinical characteristics, illness perception, fear of progression, and social alienation were collected. Descriptive analysis and Pearson correlations were conducted using IBM SPSS version 25.0. The mediating effect was analyzed using Model 4 of the PROCESS macro for SPSS, with the Bootstrap method employed to assess its significance.

Results
The score of social alienation in MHD patients was high, with illness perception and fear of progression both significantly correlated with social alienation. In the mediating effects model, illness perception can predict social alienation in MHD patients, and fear of progression use plays a part in mediating the process by which illness perception affects social alienation. The Kappa Squared (κ2) value of 21.9%, suggests a medium effect size.

Conclusions
Illness perception directly predicts social alienation in MHD patients and exerts an indirect effect through the mediating role of fear of progression. Suggests that healthcare professionals should concentrate on MHD patients with high negative illness perceptions to alleviate their fear of progression, thereby decreasing the level of social alienation and enhancing their integration into society.
Matematika Realistik : Eksplorasi Jajanan Pasar Yogyakarta Untuk Mengajarkan Materi Geometri
Authors: Antia Vindy , Suparni  
Published: April 2024

ABSTRAK

Matematika merupakan salah satu mata pelajaran yang ditakutkan oleh siswa Hal ini karena matematika terkenal dengan kesulitannya. Pembelajaran matematika dengan menggunakan pendekatan Realistic Mathematic Education (RME) membantu siswa dalam memahami materi matematika yang di sampaikan oleh guru sehingga siswa tidak merasa kesulitan. Salah satu pembelajaran matematika dengan pendekatan Realistic Mathematic Education (RME) yaitu pada materi bangun ruang geometri dengan menggunakan bentuk-bentuk pada jajanan pasar Yogyakarta. Tujuan dari penelitian ini yaitu untuk mengeksplorasi jajanan pasar Yogyakarta dalam materi bangun ruang geometri sehingga dapat digunakan dalam pembelajaran matematika dengan pendekatan Realistic Mathematics Education (RME). Metode penelitian yang digunakan dalam penelitian ini yaitu deskriptif kualitatif dengan teknik pengumpulan data yang digunakan yaitu library research atau studi pustaka. Data yang dikaji dalam penelitian ini diantaranya penjelasan singkat mengenai setiap jajanan pasar jogja yang digunakan dan analisis bentuk jajanan pasar tersebut pada bangun ruang geometri berupa bentuk, ciri-ciri dan rumus-rumusnya. Dari hasil penelitian didapatkan jajanan pasar jogja berupa arem-arem berbentuk tabung, klepon berbentuk bola, wajik berbentuk balok, clorot berbwntuk kerucut dan meniran berbentuk prisma segitiga. Jajanan pasar Yogyakarta tersebut memiliki bentuk yang berbeda-beda.
Kata kunci : geometri, jajanan pasar Yogyakarta, RME

ABSTRACT
Mathematics is one of the subjects that students are afraid of. This is because mathematics is known for its difficulties. Learning mathematics using the Realistic Mathematical Education (RME) approach helps students understand the mathematics material presented by the teacher so that students do not find it difficult. One of the mathematics lessons with the Realistic Mathematical Education (RME) approach is on geometric geometric shapes using shapes in Yogyakarta market snacks. The purpose of this study is to explore Yogyakarta market snacks in geometrical geometric shapes so that they can be used in learning mathematics using the Realistic Mathematics Education (RME) approach. The research method used in this research is descriptive qualitative with data collection techniques used namely library research or literature study. The data studied in this study include a brief explanation of each Jogja market snack used and an analysis of the shape of the market snacks in geometric shapes in the form, characteristics and formulas. From the results of the study, it was found that traditional Jogja snacks were in the form of tubular arem-arem, spherical klepon, block-shaped diamonds, invitation-shaped clorot and triangular prism-shaped meniran. The Yogyakarta market snacks have different forms.
Keywords: geometry, Yogyakarta market snacks, RME
Peningkatan Motivasi dan Hasil Belajar Matematika Peserta Didik SMP Menggunakan LKPD Berbantuan Whatsapp Group Berdasarkan Gender
Authors: Suswiyati  , Syukrul Hamdi  , Endar Chrisdiyanto  
Published: April 2024

Penelitian ini bertujuan untuk meningkatkan motivasi dan hasil belajar matematika peserta didik SMP menggunakan LKPD berbantuan WhatsApp Group berdasarkan gender. Metode penelitian menggunakan tindakan kelas tiga siklus. Pengumpulan data menggunakan tes, angket, lembar observasi, dan wawancara. Teknik analisis data deskriptif kualitatif dan uji one sample t-test. Hasil penelitian sebelum tindakan didapatkan rata-rata motivasi peserta didik laki-laki 22.73 dan perempuan 25.41. Setelah diberikan tindakan 3 siklus didapatkan nilai rata-rata peserta didik laki-laki 24,47, 25,13 dan 26,33. Nilai rata-rata peserta didik perempuan 26,65, 27,41 dan 29,18. Hasil uji t pada 3 siklus didapatkan nilai berturut-turut 0,029, 0,035, dan 0,03. Hasil ini menunjukkan bahwa motivasi belajar peserta didik perempuan lebih tinggi daripada laki-laki. Sedangkan hasil belajar sebelum diberikan tindakan didapatkan nilai rata-rata peserta didik laki-laki 42,00 dan perempuan 60,59. Setelah diberikan tindakan 3 siklus didapatkan nilai rata-rata peserta didik laki-laki 58,33, 70,67, dan 78,67. Nilai rata-rata peserta didik perempuan 71,18, 83,53, dan 88,24. Hasil Uji t pada siklus 1 dan 2 berturut-turut 0,042, dan 0,035. Sedangkan pada siklus 3 tidak ada perbedaan hasil belajar peserta didik berdasarkan gender. Berdasarkan analisis data maka penggunaan LKPD berbantuan WhatsApp Group kelas VIIIA efektif dalam meningkatkan motivasi dan hasil belajar matematika yang didasarkan pada perbedaan gender.
Kata Kunci: Gender, Hasil Belajar, Motivasi Belajar, Pembelajaran Matematika
Entre serpientes y escaleras: Las trayectorias de un grupo de estudiantes indígenas en la universidad
Authors: Perez-Castro Judith 
Published: April 2024

Los estudiantes indígenas representan el 1% de la matrícula en el nivel superior en México. La exclusión de la que han sido objeto constituye un problema estructural en el que confluyen factores internos y externos al sistema educativo. En este trabajo, abordamos las barreras y facilitadores en los estudiantes universitarios de origen indígena. La investigación se basó en la etnografía colaborativa y para el trabajo empírico realizamos entrevistas a profundidad a un grupo de alumnos y alumnas indígenas de la Universidad Nacional Autónoma de México (UNAM). En sus testimonios, los jóvenes apuntan a tres tipos de barreras principalmente: económicas, académicas y actitudinales con consecuencias tanto en sus aprendizajes y logro educativo, como en sus posibilidades de sentirse incluidos en la universidad. No obstante, paralelamente, destacan la existencia de ciertos apoyos, tanto a nivel institucional como de parte de sus familiares, compañeros y profesores. Concluimos que la situación que viven las y los jóvenes de los pueblos originarios es compleja, debido a los múltiples obstáculos que tienen que sobrellevar, de ahí que sea necesario fortalecer las acciones institucionales para identificar las necesidades de las y los estudiantes y mejorar sus condiciones educativas.
Discordant gene expression in subcutaneous adipose and skeletal muscle tissues in response to exercise training
Authors: Svensson Michael , Lovric Alen , Åkerfeldt Torbjörn , Hellsten David , Haas Tara , Gustafsson Thomas , Rullman Eric 
Published: April 2024

AbstractExercise has different effects on different tissues in the body, the sum of which may determine the response to exercise and the health benefits. In the present study, we aimed to investigate whether physical training regulates transcriptional network communites common to both skeletal muscle (SM) and subcutaneous adipose tissue (SAT). Eight such shared transcriptional communities were found in both tissues. Eighteen young overweight adults voluntarily participated in 7 weeks of combined strength and endurance training (five training sessions per week). Biopsies were taken from SM and SAT before and after training. Five of the network communities were regulated by training in SM but showed no change in SAT. One community involved in insulin‐ AMPK signaling and glucose utilization was upregulated in SM but downregulated in SAT. This diverging exercise regulation was confirmed in two independent studies and was also associated with BMI and diabetes in an independent cohort. Thus, the current finding is consistent with the differential responses of different tissues and suggests that body composition may influence the observed individual whole‐body metabolic response to exercise training and help explain the observed attenuated whole‐body insulin sensitivity after exercise training, even if it has significant effects on the exercising muscle.
The BKCa (slo) channel regulates the cardiac function of Drosophila
Authors: Gururaja Rao Shubha , Lam Alexander , Seeley Sarah , Park Jeniffer , Aruva Shriya , Singh Harpreet 
Published: April 2024

AbstractThe large conductance, calcium, and voltage‐active potassium channels (BKCa) were originally discovered in Drosophila melanogaster as slowpoke (slo). They are extensively characterized in fly models as ion channels for their roles in neurological and muscular function, as well as aging. BKCa is known to modulate cardiac rhythm and is localized to the mitochondria. Activation of mitochondrial BKCa causes cardioprotection from ischemia–reperfusion injury, possibly via modulating mitochondrial function in adult animal models. However, the role of BKCa in cardiac function is not well‐characterized, partially due to its localization to the plasma membrane as well as intracellular membranes and the wide array of cells present in mammalian hearts. Here we demonstrate for the first time a direct role for BKCa in cardiac function and cardioprotection from IR injury using the Drosophila model system. We have also discovered that the BKCa channel plays a role in the functioning of aging hearts. Our study establishes the presence of BKCa in the fly heart and ascertains its role in aging heart function.
“And then We Were Taken to Ravensbrück.” Early Oral Testimonies About Ravensbrück and Its Sub Camps
Authors: Zezza Stefania 
Published: April 2024

Abstract
This article focuses on the analysis and interpretation of 15 testimonies collected immediately after the war by David Boder and by the Polish Historical Institute in Sweden with women deported to Auschwitz, evacuated to Ravensbrück in its last two phases and then to Malchow. The study of their statements can provide both a historical overview of Ravensbrück and its sub camps in 1944 and 1945, and help identify the effects of the camp, an overthrown social context, on individuals, women in this case, and groups. The comparative exam of the interviews allows to identify the crucial events and experiences which constitute the core of the interviewees’narration and representation of the events. The situations and episodes they chose to recall may explain their perception of the events and reveals a gendered perspective which affected their memories in terms of the selection of the events and their focus on specific issues. The memories were recalled in relation to social frames, which were different from those the survivors were previously used to and pertained to the context of the camp. These coordinates constitute a net which can provide an insight into the mechanism of memory construction and early representation of the Holocaust.
Techniques to mitigate the admission of radon inside buildings
Authors: Real Luís Pimentel , Linares-Alemparte Pilar , Poças Ana Reis , Viegas João Godinho 
Published: April 2024

Abstract
In this work, the factors that influence indoor radon (Rn) level and most usual methods to prevent or mitigate Rn are presented and discussed, according to their way of action. The findings show that it is possible to select the most appropriate and effective solutions for each situation, even in cases where there is a high risk of Rn concentration, by combining these methods to increase overall efficiency. Finally, most relevant strategic recommendations are presented to guarantee the success of Rn protection measures, to reduce problems associated with Rn.
Impact of ionic liquids on the thermal properties of polymer composites
Authors: Shamsuri Ahmad Adlie , Abdan Khalina , Yusoff Mohd Zuhri Mohamed , Jamil Siti Nurul Ain Md. 
Published: April 2024

Abstract
The integration of ionic liquids and polymer composites has become a promising way to improve their thermal properties, representing a notable advancement in the development of advanced materials for specific applications. Their thermal properties heavily influence the suitability of polymer composites for particular applications. It is imperative to understand and manipulate the thermal behavior of these composites to optimize their performance across various fields. In this mini-review, diverse polymer matrices and fillers utilized in polymer composites containing ionic liquids are categorized. Additionally, various ionic liquids employed in studies related to the thermal properties of polymer composites are identified. The impact of ionic liquids on the thermal properties of these composites is also briefly reviewed. The knowledge illustrated in this review enriches the understanding of the types of polymer matrices and fillers used in conjunction with ionic liquids, as well as their thermal properties. In a nutshell, imidazolium-based ionic liquids with tetrafluoroborate, bis(trifluoromethylsulfonyl)imide, hexafluorophosphate, halides, and hydrogen sulfate anions have the impact of improving the glass transition temperature, melting temperature, degradation temperature, and thermal conductivity of thermoplastic, thermosetting, and elastomer composites.
Do health-promoting lifestyle approaches manage mental health among adolescent/young college students?
Authors: Omidvar Shabnam , Khajavi Nazanin , Pasha Hajar , Mohsenzadeh Ledari Farideh , Sepidarkish Mahdi , Adib-Rad Hajar , Ezoji Khadijeh 
Published: April 2024

Abstract

Objectives
College students are often still relatively young, making their mental health more likely to be overlooked. A healthy lifestyle is considered the key to preventing and controlling mental health problems nowadays. This study aimed to investigate whether health-promoting lifestyle approaches manage mental health among adolescent/young college students.

Methods
This cross-sectional study was conducted on 187 adolescent/young college students at Babol Medical Science University, Babol, Iran. Characteristic demographics, health-promoting lifestyle profile (HPLP), and general health questionnaire-28(GHQ-28) were filled out by students. The data were analyzed using correlation coefficient and simple and multiple linear regressions.

Results
The majority of participants were adolescents (66.8%), single (97.9%), and bachelor's students (70.1%). The mean of the HPLP and GHQ scores was 125.09±18.12, and 33.58±10.50, respectively. HPLP was a negative significant predictor of mental health (β = -.261, P= .0001). There was a negative significant association between HPLP dimensions (except physical activity) and mental health. After adjusting for other variables, there was a significant relationship between HPLP with mother occupation (β =.186, P=.038), and mother education (β = -.219, P= .034). Furthermore, gender (β = .175, P= .031), and occupation (β =-.157, P= .040) were predictors of GHQ in adolescent/young college students.

Conclusions
Regarding the health-promoting lifestyle situation among students and its relation with the better mental health, the design and implementation of HPLP education programs is recommended.