bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research on the effect of the trajectory of the spinning tool on the shape of the product in the process of axially asymmetric spin forming
Authors: Gądek Tomasz , Majewski Marcin , Sułek Bartosz Krzysztof , Plewa Krzysztof 
Published: February 2024

Abstract

The method of developing the trajectory of a shaping tool in classical spinning is relatively simple and fast, and does not require complicated operations. Such a solution is facilitated by tool kinematics. Rotational forming of asymmetrical products, due to different, more sophisticated, tool kinematics, requires the generation of a very complex trajectory, which takes a long time to prepare. The paper analyzes and describes two methods for writing and generating the trajectory of the movement of a spinning tool’s roll during the shaping of axially asymmetric products. The advantages and disadvantages of each method were analyzed. The shape of the developed trajectory was compared depending on the chosen method of its generation. In addition, an experimental study was conducted to verify the correctness of the developed trajectory. The study was conducted for the 1050A aluminum alloy in delivery condition H111, for the material thicknesses of 2 mm and 2.5 mm. The limitations of the shaping of axially asymmetric products due to the shape of the template were also analyzed.
RETRACTED: Antibacterial Effects of Silver Diamine Fluoride, Potassium Iodide and Nanosilver Fluoride on Dual-species Biofilm
Authors: Karaduran Büşra , Çelik Sibel , Üçüncü Merve Yıldırım , Topçuoğlu Nursen , Gök Mehmet Koray , Koruyucu Mine 
Published: February 2024

Abstract

The authors have requested that this preprint be removed from Research Square.
Urban plants with different seed dispersal modes have convergent response but divergent sensitivity to climate change and anthropogenic stressors
Authors: Song Kun , Gao Zhiwen , Pan Yingji , Zhuge Mingming , Wu Tian , Xia Tiyuan , Hu Yuandong , Da Liangjun , Cieraad Ellen 
Published: February 2024

Abstract

Spontaneous plants are crucial components of urban biodiversity. The distribution of spontaneous plants can be profoundly affected by their seed dispersal mode and environmental factors in urban systems. Since a comprehensive investigation into the drivers of successful seed dispersal modes of spontaneous plants is still lacking, we explored the impacts of natural factors, dispersal limitation, and habitat quality factors on the diversity pattern of spontaneous plants. We assessed the diversity patterns of four seed dispersal modes in 16 major cities in Yunnan province, the most biodiverse province in China. A total of 1,744 spontaneous plants of 916 genera and 175 families were recorded in 893 green patches. The dominating seed dispersal mode of urban spontaneous plants in most cities (13 out of 16) was autochory (33.5–38.7%), with hydrochory being least frequent (4.3–10.9%). Our research highlights spontaneous plants in heavily disturbed anthropogenic ecosystems, such as urban areas, tend to adopt convergent strategies to address environmental stressors. Their richness was significantly higher in colder and humid climates. However, as dispersal limitations (measured by distance to city boundary, city size and urbanization rate) increased and decrease in habitat quality (as expressed by patch area), the richness of all dispersal modes experienced a reduction. However, the sensitivities among different dispersal modes to these factors are divergent. Hydrochory exhibited the strongest sensitivity to habitat quality and climate factors. Whereas autochory demonstrated a strongest sensitivity, and anemochory showed a weakest sensitivity to dispersal limitation. These results suggest that include improving habitat quality or creating green corridors to mitigate dispersal limitation between urban areas and surrounding mountains will be valuable additions to urban biodiversity conservation efforts.
Orally delivered biodegradable targeted inflammation resolving pectin-coated nanoparticles induce anastomotic healing post intestinal surgery
Authors: Lee Jong Hyun , Reischl Stefan , Walter Robert Leon , Vieregge Vincent , Weber Marie-Christin , Xu Runxin , Chen Hao , Kasajima Atsuko , Friess Helmut , Neumann Philipp-Alexander , Kamaly Nazila 
Published: February 2024

Abstract

Although medical treatment is sucessful in most cases in patients with inflammatory bowel diseases (IBD), a percentage of patients require surgical resection of diseased bowel segments at least once in their lifetime. Healing success of the intestinal anastomosis is at high risk, especially in presence of acute inflammation. Failure of anastomotic healing is a life-threatening complication and causes high socioeconomic costs. Common anti-inflammatory medications can have detrimental effects on wound healing. Thus, targeted perioperative therapeutics supporting anastomotic healing during colitis are an urgent medical need. Here, we develop a novel basal membrane targeted controlled release, pectin-coated polymeric nanoparticle (NP) encapsulating a highly potent inflammation resolving mediator, the peptide Ac2-26. These NPs can undergo gastric passage and facilitate localized release of the therapeutic peptide in the colon via degradation of their pectin-chitosan coating by microbial pectinases, which subsequently exposes a collagen IV targeted NP surface, allowing for further binding and retention of the NPs at the intestinal wound. To test these NPs, we used a murine surgical model combining the formation of an intestinal anastomosis with the induction of a preoperative colitis by dextran sodium sulfate. In this model, perioperative administration of pectin-chitosan coated NPs containing Ac2-26 (P-C-Col IV-Ac2-26-NP) led to the reduction of colitis activity in the postoperative phase. Macroscopic wound closure was improved by P-C-Col IV-Ac2-26-NP treatment as evaluated by endoscopy and intraabdominal adhesion scoring. Microscopic analysis of the healing process showed an improved semiquantitative healing score in the treatment group. In this proof-of-concept study we demonstrate that novel P-C-Col IV-Ac2-26-NP could be a promising and clinically feasible perioperative treatment strategy for IBD patients.
Long-term Outcomes After Particle Radiation Therapy in Patients with Nasopharyngeal Adenoid Cystic Carcinoma
Authors: Hu Weixu , Hu Jiyi , Huang Qingting , Gao Jing , Zhang Haojiong , Kong Lin 
Published: February 2024

Abstract

Background
Nasopharyngeal adenoid cystic carcinoma (NACC) a is a relatively rare salivary gland tumor and is generally associated with a poor outcome. High-dose radiotherapy is a key treatment in patients with NACC. This study reported the long-term efficacy and safety of particle beam radiation therapy (PBRT) for NACC.
Methods and materials:
Twenty-six patients with nonmetastatic NACC who received definitive PBRT alone were included in this retrospective study. The majority of patients (92.3%) had locally advanced disease. Twenty-four (96.15%) patients received intensity-modulated proton radiotherapy (IMPT) followed by a carbon ion radiotherapy (CIRT) boost, and one patient receive CIRT alone. Overall survival (OS), local control (LC), regional control (RC), and distant metastasis control (DMC) rates were calculated via the Kaplan-Meier method.
Results
The median follow-up time was 46.95 months for the entire cohort. Seven patients experienced local recurrence, and neck lymph node relapse occurred in one patient. The 3- and 4-year OS, LC, RC, and DMC rates were 100% and 91.7%, 92.3% and 84.6%, 95.8% and 87.8%, and 90.2% and 71.3%, respectively. 91.3% of the patients achieved complete remission of gross tumor at 1 year after PBRT. Severe acute toxicity was only observed in two patients. One patient with orbital apex invasion developed grade 4 visual acuity decrease. No late grade 3 or 5 toxicity was observed.
Conclusion
Definitive PBRT provided a satisfactory 4-year OS for locally advanced NACC. Toxicity was acceptable and mild. Further follow-up is necessary to confirm the efficacy and safety of definitive PBRT for patients with NACC.
Combined transcriptomic and proteomic analysis reveals the mechanism of Xing-Qi-Huo-Xue granules on BLM-induced pulmonary fibrosis in rats
Authors: Gao Jian , Yang Han , Jiang HuanYu , Hao YanWei , Li GangGang , Zhang YuWei , Hu SiYing , Su YuChen , Du QuanYu , Wang Fei 
Published: February 2024

Abstract

Background
Pulmonary fibrosis is a phenotype of many lung disease pathologies, characterized by alveolar structure destruction, extracellular matrix anomalous accumulation, and abnormal collagen deposition. Traditional Chinese medicine is becoming increasingly important in treating pulmonary fibrosis, and Xing-Qi-Huo-Xue (XQHX) granules have been clinically proven effective, but the underlying mechanism is unclear.
Purpose
In this experiment, The mechanism of XQHX in treating rats with PF was elucidated by combined transcriptomic and proteomic analyses.
Method
The main components of XQHX granules was detected by liquid chromatography/mass spectrometry (LC/MS) first. A bleomycin (BLM)-induced rat model was established and lung histology was assessed by hematoxylin eosin and Masson's stain. Rat lung tissues were subjected to transcriptome and proteome sequencing, and bioinformatic analyses of differential genes/proteins were performed. Collagen I/III mRNA expression levels were determined by RT-qPCR, and lung hydroxyproline (HYP) levels were determined by colorimetric assay.
Results
A total of 16 main compounds including agroastragaloside IV, astragaloside I, astragaloside II, etc. in XQHX were detected by LC/MS. XQHX significantly improved BLM-induced lung tissue structure destruction and HYP content. Furthermore, XQHX inhibited lung tissue mRNA expression of collagens I, and III. Bioinformatics analysis showed that 1657 genes and 590 proteins were differentially expressed in the normal control group (N) compared to the BLM-induced control group (P), and 2.46 g/kg XQHX- treated group (X) had 805 genes and 499 proteins differentially expressed. Then we identified that XQHX exerts an anti-fibrotic effect by regulating arginine (Arg1), which is involved in the arginine biosynthesis pathway and the arginine and proline metabolism pathway.
Conclusion
Our results suggest that XQHX reduces arginase biosynthesis by down-regulating Arg1 expression as a central mechanism and potential therapeutic approach to prevent BLM-induced pulmonary fibrosis.
Optimization of Bus Stop Location based on Spatial Analysis and K-Means Clustering Method – A Case Study in Hohhot City
Authors: Yu Jingqiao , Zhu Yuan , Wu Chaowen , Song Guoqing 
Published: February 2024

Abstract
The location of bus stops is crucial for attracting bus passengers. Researchers have explored various methods, such as questionnaire surveys and field investigations, to determine the location of bus stops, but these methods largely rely on experience and intuition. With the introduction of big data, a more scientific approach has emerged for siting bus stops. Based on the location data from cellular base stations in Hohhot, China, this paper uses K-means clustering and spatial analysis to calculate the coordinates of bus stops within 4 kilometers of the central business district (CBD) area. Then the study utilizes the city point of interest (POI) data to compare the new bus stops and existing ones in terms of the POI number, bus stop spacing, and POI average distance. The study concludes that the new bus stops outperform the existing ones in terms of POI number and stops spacing. The Analytic Hierarchy Process (AHP) is applied to evaluate the results that indicate the newly constructed bus stops are superior to the existing ones, with an overall optimization rate of 3.194%.The findings of this study can serve as decision-making references for urban planning departments and public transportation operators, aiming to increase public transport passenger flow and improve the traffic conditions in cities. Additionally, the methods utilized in this research can be applied to other cities, assisting them in site selection of bus stops and optimal planning, thereby promoting the development of public transportation.
Imaging characteristics of hypervascular focal nodular hyperplasia-like lesions in chronic alcoholic liver disease
Authors: Urase Atsushi , Tsurusaki Masakatsu , Kozuki Ryohei , Kotera Taku , Kono Atsushi , Sofue Keitaro , Ishii Kazunari 
Published: February 2024

Abstract

Purpose
We evaluated diagnostically differential radiological findings between focal nodular hyperplasia (FNH)-like lesions and hepatocellular carcinoma (HCC).
Materials and Methods
We studied pathologically confirmed FNH-like lesions in 13 alcoholic-cirrhosis patients who were negative for hepatitis-B surface antigen and hepatitis-C virus antibody and underwent dynamic computed tomography (CT) and magnetic resonance imaging (MRI), including superparamagnetic iron oxide (SPIO) and/or gadoxetic acid-enhanced MRI. Seven patients underwent angiography-assisted CT. Evaluated lesion features included arterial enhancement pattern, washout appearance (low density compared to surrounding liver parenchyma), signal intensity on T1-weighted image (T1WI) and T2-weighted image (T2WI), central scar presence, chemical shift on in- and out-of-phase images, and uptake pattern on gadoxetic acid-enhanced MRI hepatobiliary phase and on SPIO-enhanced MRI.
Results
Eleven patients had multiple small lesions (< 1.5 cm). Radiological features of FNH-like lesions included hypervascularity despite small lesion, lack of “corona-like” enhancement in the late phase on CT during hepatic angiography (CTHA), high-intensity on T1WI, slightly high- or iso-intensity on T2WI, no signal decrease in out-of-phase images, and complete SPIO uptake or incomplete/partial uptake of gadoxetic acid. Pathologically, like HCC, FNH-like lesions showed many unpaired arteries and sinusoidal capillarization, similar to those in HCC.
Conclusion
FNH-like lesions have unique radiological findings useful for differential diagnosis. Specifically, SPIO- and/or gadoxetic acid-enhanced MRI and CTHA features might facilitate differential diagnosis of FNH-like lesions and HCC.
Depression in the Schistosomiasis japonica Population Based on the PHQ-9 Scale: A Cross-Sectional Survey from Jiangxi Province, China
Authors: Hu Aizhen , Liu Dele , Xie Huiqun , Wu Xia , Liu Kexing , Zhang Xuyun , Li Linlin , Zhou Xing , Hu Fei 
Published: February 2024

Abstract

Depression is the second leading-cause of disability in China. Although studies have shown that more than 80% of patients with advanced schistosomiasis (AS) suffer from anxiety and depression, these study groups are all hospitalized patients with AS and do not represent the extent of the disease in the whole group. To our knowledge, there are no studies assessing the severity of depression in patients with other forms of schistosomiasis japonicum. Therefore, it is necessary to evaluate the occurrence and potential risk factors of depression in the schistosomiasis endemic population. This cross-sectional study was conducted in Jiangxi Province, where schistosomiasis is relatively common in China, as the investigation site. The Patient Health Questionnaire-9 (PHQ-9) scale was selected to assess the depressive symptoms in the study population. At the same time, basic personal information of the research subjects and relevant socio-economics and schistosomiasis endemic area indicators were collected. The survey results show that AS has the highest incidence of depression (34.35%), while non-advanced schistosomiasis (N-AS) and control group (CG) have 22.35% and 22.24% respectively; the incidence of depression in AS is significantly higher than in N-AS and CG, while there is no statistical significance in the comparison between N-AS and CG; the incidence of mild depressive symptoms accounts for 61.08%-75.54% of the total incidence of depression in different groups; Multivariate analysis shows that the occurrence of moderate/severe depressive symptoms in the AS group was significantly related to above 60 years old, male, the combination of other serious diseases, personal financial difficulties, and marshland and lake endemic areas. In the N-AS group, the occurrence of moderate/severe depressive symptoms was significantly related to the combination of other serious diseases, personal financial difficulties, marshland and lake endemic areas and the degree of schistosomiasis epidemic control. In conclusion, depression is still relatively common among patients with schistosomiasis patients, especially those with AS. It is recommended that the government and relevant departments consider mental health care when developing prevention and control work in schistosomiasis-endemic areas, in order to effectively protect the physical and mental health of schistosomiasis patients and residents in endemic areas.
Rare Variants Analyses Suggest Novel Cleft Genes in the African Population
Authors: Alade Azeez , Mossey Peter , Awotoye Waheed , Busch Tamara , Oladayo Abimbola , Aladenika Emmanuel , Olujitan Mojisola , Gowans J.J Lord , Eshete Mekonen A. , Adeyemo Wasiu L. , Zeng Erliang , Otterloo Eric , O’Rorke Michael , Adeyemo Adebowale , Murray Jeffrey C. , Cotney Justin , Lachke Salil A. , Romitti Paul , Butali Azeez , Wentworth Emma , Anand Deepti , Naicker Thirona 
Published: February 2024

Abstract

Non-syndromic orofacial clefts (NSOFCs) are common birth defects with a complex etiology. While over 60 common risk loci have been identified, they explain only a small proportion of the heritability for NSOFC. Rare variants have been implicated in the missing heritability. Thus, our study aimed to identify genes enriched with nonsynonymous rare coding variants associated with NSOFCs. Our sample included 814 non-syndromic cleft lip with or without palate (NSCL/P), 205 non-syndromic cleft palate only (NSCPO), and 2150 unrelated control children from Nigeria, Ghana, and Ethiopia. We conducted a gene-based analysis separately for each phenotype using three rare-variants collapsing models: (1) protein-altering (PA), (2) missense variants only (MO); and (3) loss of function variants only (LOFO). Subsequently, we utilized relevant transcriptomics data to evaluate associated gene expression and examined their mutation constraint using the gnomeAD database. In total, 13 genes showed suggestive associations (p = E-04). Among them, eight genes (ABCB1, ALKBH8, CENPF, CSAD, EXPH5, PDZD8, SLC16A9, and TTC28) were consistently expressed in relevant mouse and human craniofacial tissues during the formation of the face, and three genes (ABCB1, TTC28, and PDZD8) showed statistically significant mutation constraint. These findings underscore the role of rare variants in identifying candidate genes for NSOFCs. Main documents (excluding the methods section) word count: 2145
Isotopologues of Potassium 2,2,2-Trifluoroethoxide for Applications in Positron Emission Tomography and Beyond
Authors: Pike Victor , Zhao Qunchao , Telu Sanjay , Jana Susovan , Morse Cheryl 
Published: February 2024

Abstract

The 2.2.2-trifluoroethoxy group increasingly features in drugs and potential tracers for biomedical imaging with positron emission tomography (PET). Herein, we describe a novel rapid and metal-free conversion of fluoroform with paraformaldehyde into highly reactive potassium 2,2,2-trifluoroethoxide (CF3CH2OK) and demonstrate robust applications of this synthon in one-pot, two-stage 2,2,2-trifluoroethoxylations of both aromatic and aliphatic precursors. Moreover, we show that these novel transformations translate easily to fluoroform that has been labeled with either carbon-11 (t1/2 = 20.4 min) or fluorine-18 (t1/2 = 109.8 min), so allowing the appendage of complex molecules with a no-carrier-added 11C- or 18F- 2,2,2-trifluoroethoxy group. This provides enormous scope to provide new candidate PET tracers with radioactive and metabolically stable 2,2,2-trifluoroethoxy moieties. We also exemplify syntheses of isotopologues of potassium 2,2,2-trifluoroethoxide and show their utility for stable isotopic labeling which can be of further benefit for drug discovery and development.
Willingness to participate in a personalized health cohort – Insights from the Swiss Health Study pilot phase
Authors: Bühler Nolwenn , Frahsa Annika , Jaramillo Nathalia González , Bourqui Réjane Morand , Nusslé Semira Gonseth , Zuppinger Claire , Bochud Murielle , Goetz Natalie 
Published: February 2024

Abstract

Background
This paper explores the feasibility of establishing a personalized health cohort by assessing potential participants’ needs, expectations, and concerns.
Methods
Employing a participatory approach, we utilized a scenario-based questionnaire in the Swiss Health Study pilot phase (2020-2021involving 1349 adults aged 20–69 from the cantons Vaud and Bern. We conducted descriptive statistics supported by R and qualitative content analysis for open responses related to attitude towards research. We highlight the benefits and challenges of the scenario-based approach, discuss the sample represented in the pilot phase, and implications for building a full cohort, and present participants’ attitudes towards and previous experience with health research. We analyze references regarding informed consent and feedback, attitudes towards a Swiss Health Study, and recommendations on how to improve its scope, design, and instruments.
Results
Results indicate a high interest (90%) in participating in a national health study, with 85% of a random population sample willing to join a long-term cohort. Only 43% were familiar with biobanks, and 44% preferred general consent. Trust was high for Swiss-based public research but lower for researchers outside the country or in the private sector. Over 95% expressed willingness to complete online questionnaires, undergo physical examination, and donate biosamples. Almost all participants wanted to know the outcomes of medical visits (99.5%), and environmental exposure assessments (95%). Preferred tools for monitoring sleep, physical activity, and diet were known smartphone apps with automatic data management.
Conclusion
Overall, the study reveals a positive attitude towards personalized health research, with a strong willingness to share data and samples. Key insights focus on informed consent variations, cohort participation and representativeness, and the significance of personalized feedback —especially regarding environmental health concerns. Findings emphasize participants’ supportive yet reflexive stances, underscoring the importance of aligning research values with individual values in personalized health research. These insights contribute valuable considerations for refining the scope, design, and instruments of future cohort studies.