bluuebunny/crossref_metadata_2025_split huggingface dataset:
New approach to soil fertility management: Biogeosystem Technique methodology (critical review)
Authors: Kalinitchenko Valery P. , Swidsinski Alexander V. , Glinushkin Alexey P. , Overcash Michael R. , Meshalkin Valery P. , Minkina Tatiana M. , Rajput Vishnu D. , Chernenko Vladimir V. , Mandzhieva Saglara S. , Sushkova Svetlana N. , Rykhlik Artyom E. , Larin Georgiy S. , Gudkov Sergey V. , Baryshev Mikhail G. , Sevostyanov Mikhail A. , Makarenkov Dmitry A. 
Published: February 2024

AbstractA standard management soil priming effect is short term. A current soil plowing, irrigation and waste utilization soil priming action shortcomings elimination is needed. The Biogeosystem Technique (BGT*) priming action system was developed for soil management to provide a higher‐level priming effect. The BGT* is focused on a soil biogeochemical cycle activation similar to the biodegradation in a colon of a live organism as an efficient benchmark bioreactor. Fluorescence in situ hybridization showed a cooperation of bacteria within polymicrobial biofilms and a probability of the polymicrobial biofilms biodegradation process acceleration and soil organic matter (SOM) regime improvement. The soil priming actions the BGT* technological management is capable of providing are based on the BGT* constituents, whose essence, applications and corresponding detailed data are presented in available studies. The main BGT* components are as follows. The illuvial horizon intra‐soil milling artificial soil aggregation (a form of crumbling and mixing) priming action provides the soil structuring, a SOM content increase and an annual yield increment direct priming effects. A long‐term secondary priming effect is a technology life cycle with higher profitability compared to the standard moldboard, chiseling and three‐tier plowing. The intra‐soil pulse sequential‐discrete watering priming action is performed through water injection into the soil in sequence. A next water spreading provides the soil aggregate stability, the seedling length and weight increment direct priming effect and a water‐saving secondary priming effect. The intra‐soil dispersed liquid, paste‐like and loose granular nutrition and structuring matter intra‐soil milling application priming action ensures soil structuring direct priming effects, heavy metals passivation and long‐term yield increment secondary priming effects. The BGT* methodology could be useful for soil management improvement.
Effect of CHRDL1 on angiogenesis and metastasis of colorectal cancer cells via TGF‐β/VEGF pathway
Authors: Li Junfeng , Jiang Zhongxiang , He Jin , Yang Kun , Chen Jun , Deng Qianxi , Li Xiaoqing , Wu Fan , Xu Shuman , Jiang Zheng 
Published: February 2024

AbstractColorectal cancer (CRC) is a common digestive tract tumor with the third incidence and death in the world. There is still an urgent need for effective therapeutic targets and prognostic markers for CRC. Herein, we report a novel potential target and marker, Chordin like‐1 (CHRDL1). The function of CHRDL1 has been reported in gastric cancer, breast cancer, and oral squamous cell carcinoma. However, the biological effect of CHRDL1 in CRC remains unrevealed. Transwell and tube formation experiments were used to determine the biological function of CHRDL1. Western blot and rescue experiments were used to determine the specific mechanisms of CHRDL1. Results showed CHRDL1 is significantly downregulated in CRC cell lines and tissues. In vitro, experiments confirmed that CHRDL1 can inhibit cell growth, migration, invasion, angiogenesis and reverse epithelial‐mesenchymal transformation. In vivo, experiments proved that it can inhibit tumor growth and metastasis. Mechanistically, we newly find that CHRDL1 exerts biological functions through the transforming growth factor‐beta (TGF‐β)/vascular endothelial growth factor signaling axis in vitro and in vivo. Therefore, we concluded that CHRDL1 reduces the growth, migration, and angiogenesis of CRC cells by downregulating TGF‐β signaling. Our new findings on CHRDL1 may provide a basis for clinical antiangiogenesis therapy and the prognosis of CRC.
Reticulon 3 deficiency ameliorates post‐myocardial infarction heart failure by alleviating mitochondrial dysfunction and inflammation
Authors: Qi Bingchao , Li Tiantian , Luo Haixia , Hu Lang , Feng Renqian , Wang Di , Peng Tingwei , Ren Gaotong , Guo Dong , Liu Mingchuan , Wang Qiuhe , Zhang Mingming , Li Yan 
Published: February 2024

AbstractMultiple molecular mechanisms are involved in the development of heart failure (HF) after myocardial infarction (MI). However, interventions targeting these pathological processes alone remain clinically ineffective. Therefore, it is essential to identify new therapeutic targets for alleviating cardiac dysfunction after MI. Here, gain‐ and loss‐of‐function approaches were used to investigate the role of reticulon 3 (RTN3) in HF after MI. We found that RTN3 was elevated in the myocardium of patients with HF and mice with MI. Cardiomyocyte‐specific RTN3 overexpression decreased systolic function in mice under physiological conditions and exacerbated the development of HF induced by MI. Conversely, RTN3 knockout alleviated cardiac dysfunction after MI. Mechanistically, RTN3 bound and mediated heat shock protein beta‐1 (HSPB1) translocation from the cytosol to the endoplasmic reticulum. The reduction of cytosolic HSPB1 was responsible for the elevation of TLR4, which impaired mitochondrial function and promoted inflammation through toll‐like receptor 4 (TLR4)/peroxisome proliferator‐activated receptor gamma coactivator‐1 alpha(PGC‐1α) and TLR4/Nuclear factor‐kappa B(NFκB) pathways, respectively. Furthermore, the HSPB1 inhibitor reversed the protective effect of RTN3 knockout on MI. Additionally, elevated plasma RTN3 level is associated with decreased cardiac function in patients with acute MI. This study identified RTN3 as a critical driver of HF after MI and suggests targeting RTN3 as a promising therapeutic strategy for MI and related cardiovascular diseases.
Sex differences in insulin regulation of skeletal muscle glycogen synthase and changes during weight loss and exercise in adults
Authors: Ryan Alice S. , Li Guoyan , McMillin Shawna , Ortmeyer Heidi K. 
Published: February 2024

AbstractObjectiveThe authors sought to understand sex differences in muscle metabolism in 73 older men and women.MethodsBody composition, VO2max, and insulin sensitivity (M) by 3‐hour hyperinsulinemic‐euglycemic clamp with vastus lateralis muscle biopsies were measured.ResultsWomen had lower body weight, VO2max, and fat‐free mass than men. Men had lower M, lower change (insulin minus basal) in muscle glycogen synthase (GS) activity, and lower change in AKT protein expression than women. M was associated with the change (insulin‐basal) in GS activity and the change in AKT protein expression. Sex differences (n = 60) were tested with 6‐month weight loss or 3×/week aerobic exercise training. The postintervention minus preintervention change (insulin‐basal) (∆∆) in GS activity (fractional, independent, total) was higher in men than women in the weight loss group and ∆∆ in GS fractional activity was higher in women than men in the aerobic exercise group. In all participants, ∆∆ in GS fractional and independent activities was related to ∆∆ in AKT expression and glycogen content.ConclusionsSex differences in insulin sensitivity may be explained at the cellular muscle level, and to improve skeletal muscle insulin action in older adults, it may be necessary to recommend different behavioral strategies depending on the individual's sex.
Efficacy and safety of tirzepatide, GLP‐1 receptor agonists, and other weight loss drugs in overweight and obesity: a network meta‐analysis
Authors: Pan Xin‐Hui , Tan Bryan , Chin Yip Han , Lee Ethan Cheng Zhe , Kong Gwyneth , Chong Bryan , Kueh Martin , Khoo Chin Meng , Mehta Anurag , Majety Priyanka , Grandhi Gowtham R. , Dimitriadis Georgios K. , Foo Roger , Chew Nicholas W. S. , Le Roux Carel W. , Mamas Mamas A. , Chan Mark Y. 
Published: February 2024

AbstractObjectiveThis network meta‐analysis evaluates the efficacy and safety of tirzepatide compared to glucagon‐like peptide‐1 receptor agonists (GLP‐1 RA) and other weight loss drugs in the treatment of overweight and obesity.MethodsMEDLINE, Embase, and Cochrane CENTRAL were searched for randomized controlled trials on tirzepatide, GLP‐1 RA, and weight loss drugs approved by the US Food and Drug Administration. A network meta‐analysis was performed, drawing direct and indirect comparisons between treatment groups. Network diagrams and surface under the cumulative ranking curve analysis were performed for primary (≥5%, ≥10%, ≥15%, absolute weight loss) and secondary outcomes and adverse effects.ResultsThirty‐one randomized controlled trials, involving more than 35,000 patients, were included in this study. Tirzepatide 15 mg ranked in the top three across weight‐related parameters, glycemic profile (glycated hemoglobin), lipid parameters (total cholesterol, high‐density lipoprotein cholesterol, low‐density lipoprotein cholesterol, triglycerides), and blood pressure. Tirzepatide 15 mg had the highest efficacy compared with placebo for achieving ≥15% weight loss (risk ratio 10.24, 95% CI: 6.42–16.34). As compared to placebo, tirzepatide and GLP‐1 RA across all doses had significant increases in gastrointestinal adverse effects.ConclusionsThe superiority of tirzepatide and GLP‐1 RA in inducing weight loss and their ability to target multiple metabolic parameters render them promising candidates in the treatment of patients with overweight and obesity.
Outcomes of Head and Neck Free Tissue Transfer Requiring Vein Grafting: Systematic Review and Meta‐analysis
Authors: Kota Sharwani , Khan Najm S. , Bollig Kassie , Bridgeman Matthew , Bollig Craig A. 
Published: February 2024

AbstractObjectiveTo systematically review the literature to determine the prevalence of free flap failure in head and neck free flaps requiring vein grafting.Data SourcesSearch strategies created in collaboration with a medical librarian were implemented using PubMed, Cochrane, Scopus, Web of Science, and Google Scholar from inception to August 2022.Review MethodsThe population of interest included adult and pediatric patients undergoing reconstruction of oncologic or traumatic head and neck defects with a free flap requiring a vein graft that presents the success/failure rate. The primary outcome was the flap failure rate, and the secondary outcome was the flap compromise/revision rate. Inclusion and exclusion criteria were designed to capture all study designs. Initially, 2778 articles were identified by the search strategy. Two reviewers independently performed the review, data extraction for analysis, and a quality assessment. Primary Reporting Items for Systematic Reviews and Meta‐analyses guidelines were followed. Meta‐analysis was performed using a random effects model.ResultsEleven studies of 789 flaps were included for data extraction. Random effects meta‐analysis resulted in an estimated prevalence of free flap failure of 12.30% (95% confidence interval: 6.39%‐19.49%, I2 = 77.4%).ConclusionTaking into account that head and neck free tissue transfers that require a vein graft are typically associated with more challenging reconstructions and the lack of a suitable alternative, vein grafts appear to be a reliable method for bridging the gap between the flap and recipient vessels in head and neck free tissue transfer when indicated.
Association of Sleep Characteristics with Tinnitus and Hearing Loss
Authors: Awad Matthew , Abdalla Ibrahim , Jara Sebastian M. , Huang Tina C. , Adams Meredith E. , Choi Janet S. 
Published: February 2024

AbstractObjectiveThe impact of poor sleep on tinnitus has been mainly attributed to central processes. There is an association between sleep disorders and hearing loss, but whether hearing levels mediate the association between sleep disorders and tinnitus is unknown. This study investigates the association between sleep characteristics, tinnitus, and hearing loss.Study DesignCross‐sectional.SettingNational Health and Nutrition Examination Survey (NHANES).MethodsStudy cohort includes 9693 adults (≥20 years) from the NHANES 2005 to 2018 who completed audiometric testing and questionnaires on tinnitus and sleep characteristics. Multivariable regression analyses were performed to quantify associations between sleep characteristics, tinnitus, and hearing loss.ResultsIn this cohort, 29% (95% confidence interval [CI]: 28%‐31%) reported trouble sleeping and 9% (95% CI: 8%‐10%) reported being diagnosed with sleep disorders. Negative sleep characteristics (less hours of sleep, diagnosis of a sleep disorder, trouble sleeping, or OSA symptoms) were not associated with audiometry‐measured hearing loss in multivariable models adjusted for demographics and comorbidities but were significantly associated with bothersome tinnitus. This association remained significant without substantial attenuation in multivariable models additionally adjusting for hearing levels: sleeping <8 h/day (vs ≥8) (odds ratio [OR]: 1.28 [95% CI: 1.08‐1.52]), trouble sleeping (OR: 1.78 [95% CI: 1.45‐2.19]), diagnosis of sleep disorders (OR: 1.57 [95% CI: 1.14‐2.15]), and report of OSA symptoms (OR: 1.42 [95% CI: 1.08‐1.88]).ConclusionNegative sleep characteristics were associated with tinnitus while there was no clinically meaningful association between sleep and hearing loss. Our findings suggest that the relationship between poor sleep and tinnitus is likely contributed by central processes without a major role of mediation via the peripheral auditory system.
Opinions, attitudes and perceptions of local people towards the conservation of Nigeria‐Cameroon chimpanzees in Mpem‐Djim National Park, central Cameroon
Authors: Fotsing Ernest D. B. , Kamkeng Meigang M. F. , Zinner Dietmar 
Published: February 2024

AbstractLocal ecological knowledge (LEK), tied to specific cultures, is crucial for sustainability in conservation initiatives. Therefore, including holders of this knowledge in management decisions is essential. Collecting protected area‐specific data on local people's attitudes, opinions and perceptions towards wildlife, especially for highly threatened species like great apes, is therefore crucial for effective conservation. This study emphasizes the importance of LEK as an interdisciplinary approach, highlighting its essential role in informing conservation decisions and understanding human–environment interactions.To fill the information gap on the LEK on the Nigeria‐Cameroon chimpanzee in central Cameroon, we used questionnaires to assess the LEK of respondents specifically their perceptions, opinions and attitudes towards the population trend of chimpanzees, as well as their opinion about the current management systems of Mpem and Djim National Park. We collect data from 240 respondents in 15 villages in the neighbourhood of the park. Using generalized linear mixed models, we were also able to assess socioeconomic and demographic factors that correlate with the opinions, attitudes and perceptions of the respondents towards chimpanzee conservation.About 87% of the respondents exhibited good knowledge about chimpanzees and 59% reported taboos related to chimpanzees. About 94% were aware of laws that prohibit the hunting of chimpanzees, while 87% agreed that it is a good initiative to conserve chimpanzees, and 42% reported that their population increased. Almost half (52%) of the respondents said they were satisfied with the current park management system. Age, gender, education level, number of children in the household and time spent in the community were predictors that influenced the attitude, opinion and perception of the respondents while occupation and the geographic distance between the village and the park did not.Our findings suggest that raising awareness of human–chimpanzee coexistence through adult education programmes should target specific demographic groups, such as those with larger families, limited education, older age, individuals with lower LEK or native. These findings brought insights to guide future studies and should be taken into account when discussing regional management.Read the freePlain Language Summaryfor this article on the Journal blog.
Designing of layered double hydroxide, metal oxides, and borate‐reinforced thermoplastic polyurethanes composites
Authors: Desai Shubham , Kamble Varun , Ozarkar Vedant , Dingre Parth , Desai Pradnya , More Aarti , Mahajan Umesh , Mhaske Shashank 
Published: February 2024

AbstractThermoplastic polyurethanes (TPUs) are widely used in automotive, medical, and marine applications due to their excellent properties such as high tensile strength, flexibility, and durability. However, the presence of isocyanate groups in TPUs increases their flammability and produces toxic gases during combustion, limiting their application. Here, the study aims to modify TPUs to improve their flame‐retardant behavior. Various fillers such as metal oxides, Layer double hydroxides (LDH), and borates were synthesized and added into the TPU matrix by using extrusion and compression molding. At a 10% loading of Zinc‐Magnesium oxides, a limiting oxygen index (LOI) of 25% was achieved, along with no dripping and complete burning cessation within 20 s. Magnesium aluminium LDH exhibited maximum flame retardancy at a 5% loading, with an LOI of 25%, burning cessation within 23 s without dripping, and a V1 rating. Overall, this research aims to develop TPU composites with improved fire safety properties by incorporating various additives. The synthesized additives showed potential for enhancing the mechanical, thermal, and flame‐retardant properties of TPU.
Tensile properties of banana fiber reinforced recycled high‐density polyethylene composites: An experimental investigation
Authors: Syduzzaman Md. , Akter Mahin , Mahmud Foysal , Bhowmick Diti Rani , Maliha Afia Sultana , Fahmi Fahmida Faiza , Hossain Tanvir , Ahamed Md. Ahasan 
Published: February 2024

AbstractNatural fiber‐reinforced polymer composites (NFRCs) are increasingly favored over synthetic fiber‐reinforced alternatives due to their beneficial properties and environmental sustainability. Mechanical properties of composites are critical to ensure optimized utilization of NFRCs. Here, this research explores the effects of different fiber parameters on the tensile strength of high‐density polymer composites reinforced with banana fiber and utilizes the Taguchi method for both experimental and statistical analysis of the outcomes. Three different parameters are considered here: weight fractions, fiber orientation angle, and plasma treatment to fabricate the composites using the compression molding process. Taguchi analysis revealed that fiber orientation angle has the greatest influence among the three variables, with plasma treatment and weight fraction following in impact on tensile strength. The composite that exhibited the highest tensile strength was determined to have a weight fraction of 10%, a fiber orientation angle of 90°, and a plasma treatment period of 5 min. This combination yielded a strength of 30.351 MPa. The analysis of the interaction between any two factors was done using contour plots. In order to compare the experimental tensile strength values with the anticipated values derived from the regression equation, regression analysis was carried out.Highlights
Composites were made up of recycled HDPE (rHDPE) from plastic bottles using a compression molding technique.
The Taguchi method is applied to achieve an experimental design employing an L4 orthogonal array.
Contour plot analysis is conducted to identify points of minimum and maximum responses, as anticipated from the results.
Tensile strength was optimized to a maximum of 30.351 MPa.
Early silique‐shedding wild radish (Raphanus raphanistrum L.) phenotypes persist in a long‐term harvest weed seed control managed field in Western Australia
Authors: Ashworth Michael , Rocha Roberto Lujan , Baxter Shane , Flower Ken 
Published: February 2024

AbstractBACKGROUNDThis study introduces a wild radish population collected from Yelbeni in the Western Australian grainbelt that evolved an early silique abscission (shedding) trait to persist despite long‐term harvest weed seed control (HWSC) use. In 2017, field‐collected seed (known herein as Yelbeni) was compared to surrounding ruderal and field‐collected populations in a fully randomized common garden study.RESULTSThe Yelbeni population exhibited a higher rate of silique abscission when compared to the ruderal populations collected from the site before wheat (Triticum aestivum L.) harvest (assessed at soft dough stage, Zadoks 83). A similar common garden study was conducted in the subsequent season (2018) using progeny reproduced on a single site without stress. The HWSC‐selected progeny (Yelbeni P) shed 1048 (±288) siliques before wheat maturity at the soft dough stage (Zadoks 83) compared to 25 (±7) siliques from the pooled control populations. The Yelbeni P population only flowered 6 days earlier (FT50 as determined by log‐logistic analysis) than pooled control populations, which is unlikely to fully account for the increased rate of silique abscission. The Yelbeni P population also located its lowest siliques below the lowest height for harvest interception (10 cm), which is likely to increase HWSC evasion. The mechanism inducing early silique‐shedding is yet to be determined; however, wild radish is known for its significant genetic variability and has demonstrated its capacity to adapt to environmental and management stresses.CONCLUSIONThis study demonstrates that the repeated use of HWSC can lead to the selection of HWSC‐avoidance traits including early silique‐shedding before harvest and/or locating siliques below the harvest cutting height for interception. © 2024 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Field and postharvest application of microencapsulated Yamadazyma mexicanaLPa14: anthracnose control and effect on postharvest quality in avocado (Persea americana Mill. cv. Hass)
Authors: González‐Gutiérrez Katia Nayely , Ragazzo‐Sánchez Juan Arturo , Calderón‐Santoyo Montserrat 
Published: February 2024

AbstractBACKGROUNDAnthracnose caused by species of Colletotrichum is the most important disease of avocado fruit. The quiescent infection develops in the field, hence, its control from the preharvest stage is necessary. The field application of microencapsulated Yamadazyma mexicana LPa14 could prevent the establishment of Colletotrichum gloeosporioides and reduce the losses in avocado production. This study aimed to evaluate the effectiveness of microencapsulated Y. mexicana applied in the field and postharvest for the anthracnose control in avocado, to evaluate the population dynamics of Y. mexicana in flowers and fruits and the effect of the yeast on the avocado quality.RESULTSThe concentrations of microencapsulated Y. mexicana after field application ranged from 4.58 to 6.35 log CFU g−1. The population of microencapsulated yeast in flowers and fruits was always higher than treatments with fresh cells. Preharvest application of fresh and microencapsulated Y. mexicana significantly reduced the severity of anthracnose by 71–80% and 84–96%, respectively, in avocado fruits stored at 25 °C. Moreover, at 6 °C and ripening at 25 °C, the fresh yeast reduced the severity by 87–90% and the microencapsulated yeast by 91–93%. However, yeast treatments applied in the field + postharvest under cool conditions were more effective in reducing 100% of anthracnose. Treatments did not negatively affect the quality parameters of the avocado fruits.CONCLUSIONYamadazyma mexicana microencapsulated by electrospraying is a promising bioformulation for the management of anthracnose in avocados at preharvest and postharvest levels. Yamadazyma mexicana offers a new biological control solution for growers in avocado orchards. © 2024 Society of Chemical Industry.