bluuebunny/crossref_metadata_2025_split huggingface dataset:
ERP Influence of Velocity Structure and Direction Cue on the Coincident-timing of Tennis Landing
Authors: xiaogang ma , shi bing 
Published: March 2024

Abstract

According to the classic research paradigm of Bassin Anticipation Timer (Bassin), a tennis ball Coincident-timing stimulus material with highly representative ecological validity is designed. To explore the behavioral and ERP characteristics of tennis players' landing synchronization timing under different speed structure and direction cues. The behavioral results show that the timing error of the slow condition is higher than that of the fast condition, and the timing error of the right drop point is higher than that of the middle and left drop point. ERP results showed that the right hemisphere parietal region, parietal occipital region and occipital region of P1 and P2 showed higher amplitude than that of the left hemisphere, and the latency of P1 in the right drop point of the fast group was later than that in the middle and left drop point, and later than that in the slow group. The amplitude of N1 and N2 components induced by the right drop point was higher than the left drop point, and the latency of the right and middle drop point of N1 was later than the left drop point. The amplitude of P3 induced by the left occipital region and parieto-occipital region was higher than the left and right points, and the amplitude of Po7 was higher than the left point. The incubation period of P3 in the middle and left drop point of fast group was higher than that in the right drop point, and that in the slow drop point of right drop point was higher than that in the fast group. The electrode amplitude in the parietal and parietal occipital regions of LPP components was higher than that in the frontal and central regions. The amplitude of the right frontal area, the middle, the left frontal area and the left parietal pillow area were the highest.
Conclusion: There is an inverted U-shaped relationship between speed stimulation and physiological arousal, and the direction level is closely related to motor expertise experience and dominant eye. The latency time of the parietal and parietal occipital regions and the suppression control of the central region of ERP components have great influence on the timing error between the speed groups. The timing errors in different directions showed the advantage of the right hemisphere cognitive processing in the early stage, and the difference of the amplitude was mainly reflected in the activation intensity of the parietal, parietal and occipital regions, while the advantage of the right hemisphere cognitive processing gradually weakened in the late stage.
Fostering Oral Health in Oncology: Bridging Awareness and Action
Authors: Alananzeh Ibrahim , Qawasmeh Khaled Al , Issa Wassem Al , Chacko Selva , George Ajesh 
Published: March 2024

Abstract

Background
This exploratory qualitative study adopted a constructivist approach to investigate the existing oral health care processes and requirements of oncology clinicians in the United Arab Emirates.
Methods
Nine clinicians and healthcare providers were selected using purposive sampling. One-on-one interviews were conducted to inform participants about the study, with written consent obtained after addressing their inquiries. These in-person interviews were transcribed and analyzed using thematic and a microanalysis approach, identifying themes and patterns to comprehend the impact of oral health in oncology care.
Results
Our study found that healthcare providers in oncology care were well-versed in oral health and its significance for cancer patients. They felt confident in addressing oral health issues as part of their patient care responsibilities. Barriers, including limited resources and financial constraints, occasionally hindered access to dental care. However, these providers emphasized the importance of oral health promotion within oncology. They recommended increased availability of resources and a greater role for non-dental healthcare providers in enhancing oral health awareness and care for cancer patients.
Conclusions
The study underscores the critical role of oral health in oncology care and the importance of education, awareness, and interdisciplinary collaboration to enhance patient outcomes. Addressing barriers related to awareness, education, and resource constraints is vital to providing comprehensive oral health care. Moreover, specialized nurse practitioners focusing on oral health may play a pivotal role in improving patient outcomes by delivering dedicated oral care and patient education.
Effect of medication on the rostrolateral prefrontal oxygenation and thalamic volume asymmetry in youths with ADHD
Authors: Kim Hyuna , Kang Da Hyun , Jang Young Hun , Ahn Ja-Hye , Sojin Won , Lee Hyun Ju , Kim Johanna Inhyang 
Published: March 2024

Abstract

Symptoms of attention deficit hyperactivity disorder (ADHD) are associated with impaired executive functions. Some functional magnetic resonance imaging (fMRI) studies on medication effects have provided positive evidence of neuroactivation patterns in children with ADHD; however, they should be extended to functional near-infrared spectroscopy (fNIRS)-based examination of the neuropharmacological effects of medication. We investigated the differences in brain hemodynamic activity between 23 children with ADHD taking medication and 22 children who were not taking medication. Compared with the medicated ADHD group, the unmedicated ADHD group showed significantly reduced activation in the left rostrolateral prefrontal cortex (channel 9, p = 0.01; channel 13, p = 0.02) and dorsolateral prefrontal cortex (channel 14, p = 0.01). The unmedicated ADHD group exhibited a negative correlation between oxygenated hemoglobin (HbO) and symptom scores, while the ADHD with medication group exhibited a positive correlation. Moreover, the abnormal asymmetry of the thalamic volume was reduced in children with ADHD receiving medication compared to those not receiving medication (p = 0.02). Current findings suggest that left rostrolateral prefrontal activation and reduced thalamic asymmetry are important for inhibitory control, and that the activity of this region is restored by ADHD medication.
Electronic structure and spin dynamics of the metal-organic-framework kagome spin liquid Cu3(HOTP)2
Authors: Pratt Francis , Lopez-Alcala Diego , Garcia-Lopez Victor , Clemente-Leon Miguel , Baldovi Jose , Coronado Eugenio 
Published: March 2024

Abstract

The metal-organic-framework (MOF) compound Cu$_3$(HOTP)$_2$ is a small-gap semiconductor containing a kagome lattice of antiferromagnetically coupled $S$=1/2 Cu$^\mathrm{II}$ spins with exchange coupling of order 2 K.
First principles spin-polarized DFT+U electronic structure calculations obtain an in-plane nearest-neighbour exchange coupling that matches experiment.
Muon spin relaxation confirms no magnetic ordering down to 50~mK and sees spin fluctuations diffusing on a 2D lattice, consistent with a quantum spin liquid (QSL) ground state.
Reduction of the diffusion rate on cooling from the paramagnetic region to the low temperature QSL region is assigned to the effects of quantum entanglement.
Combined analysis of the spin diffusion, magnetic susceptibility and specific heat in the QSL region suggests close proximity to a quantum critical point and a large density of low energy spin-less electronic excitations.
A Z$_2$-linear Dirac model for the spin excitations of the QSL is found to provide the best overall consistency with experiment.
Unveiling Mechanisms and Onset Threshold of Humping in High-Speed Laser Welding
Authors: Li Jingjing , Lai Zen-Hao , Xu Siguang , Clark Samuel , Fezzaa Kamel 
Published: March 2024

Abstract

The fabrication of fuel cells relies on a rapid laser welding process. However, challenges arise with the occurrence of humping when the welding speed surpasses a critical threshold, which poses difficulties in achieving a smooth surface finish and a consistent weld strength. This study aims to elucidate the mechanisms behind humping by analyzing the morphology of molten pool and the characteristics of melt flow at varying welding speeds via in situ synchrotron high-speed X-ray imaging and computational fluid dynamics simulations. Our findings indicate that the short keyhole rear wall, the high backward melt velocity, and the prolonged tail of molten pool are the primary factors contributing to the onset of humping. Furthermore, a dimensionless humping index (π_h) was introduced, which successfully captured the onset threshold of humping across different literatures. This index not only provides a quantitative description of the humping formation tendency but also serves as a valuable tool for optimizing the laser welding process.
Diagnostic agreement between emergency medical service and emergency department physicians, a prospective multicentre study
Authors: Veldhuis Lars I. , Gouma Patrick , Ludikhuize Jeroen , Nanayakkara Prabath 
Published: March 2024

Abstract

Introduction
Early and adequate preliminary diagnosis reduce emergency department (ED) and hospital stay, and may reduce mortality. Several studies demonstrated adequate preliminary diagnosis as stated by emergency medical services (EMS) ranging between 61-77%. Dutch EMS are highly trained, but performance of stating adequate preliminary diagnosis remains unknown.
Methods
This prospective observational study included 781 patients (>18years), who arrived in the emergency department (ED) by ambulance in two academic hospitals. For each patient, the diagnosis as stated by EMS and the ED physician was obtained and compared. Diagnosis was categorized based on the International Classification of Diseases, 11th Revision.
Results
The overall diagnostic agreement was 79% [95%-CI: 76-82%]. Agreement was high for traumatic injuries (94%), neurological emergencies (90%), infectious diseases (84%), cardiovascular (78%), moderate for mental and drug related (71%), gastrointestinal (70%), and low for endocrine and metabolic (50%), and acute internal emergencies (41%). There is no correlation between 28-day mortality, the need for ICU admission or the need for hospital admission with an adequate preliminary diagnosis.
Conclusion
In the Netherlands, the extent of agreement between EMS diagnosis and ED discharge diagnosis varies between categories. Accuracy is high in diseases with specific observations, e.g., neurological failure, detectable injuries, and electrocardiographic abnormalities. Further studies should use these findings to improve patient outcome.
Influence of tibial plateau leveling osteotomy on strains placed on the patellar ligament: an ex vivo study in cranial cruciate deficient stifles
Authors: Bester Elizabeth G , Zeiler Gareth E , Stoltz George G , Oberholster Abraham J , Kitshoff Adriaan M 
Published: March 2024

Abstract

Background
Cranial cruciate ligament (CrCL) disease is a frequent cause of pelvic limb lameness in dogs. Tibial plateau leveling osteotomy (TPLO) is a common surgical intervention but can result in postoperative patella desmitis. The underlying causes are not fully understood, but can involve increased strain on the patella ligament. The aim was to assess the impact of different tibial plateau angles (TPAs) post-TPLO on patellar ligament strain in CrCL-deficient stifles during weight-bearing stance.
Methods
Patellar ligament strain was measured using a 3D method of digital image correlation to calculate Green–Lagrange strain (unitless measure), specifically E33, to yield the axial strain. Twelve pelvic limbs harvested from seven previously owner-consented euthanized dogs (> 20 kg) without pelvic limb or girdle pathology were dissected out and fitted to a custom-built jig. The limbs were positioned to mimic a loadbearing standing animal and 120 Newtons of force were applied. Strain, change in strain, and percent change in strain were measured or calculated on pre-TPLO (intact and transected CrCL) and various post-TPLO TPAs. Data were compared using a linear mixed model and applying Dunnett method of multiple comparisons (control: pre-TPLO intact CrCL) where significance was interpreted at p < 0.05. The hypothesis was that patellar ligament strain would not differ across various TPAs compared to CrCL-intact stifles, simulating weight bearing at a standard standing angle.
Results
Post-TPLO TPAs of 0° (P = 0.019) and 5° (P = 0.031) increased in patellar strain compared to pre-TPLO intact CrCL constructs. However, the change in patellar ligament strain was only different at 0° (P = 0.047) TPA. Whereas the percent change in strain were different at -5° (P = 0.041), 0° (P = 0.013) and 5° (P = 0.026) TPAs compared to pre-TPLO intact CrCL construct. The median magnitude of percent change in strain were 35.1%, 37.0% and 79.0% for − 5°, 0° and 5°, respectively.
Conclusion
TPLO rotation angle influences patellar ligament strain. TPLO with a 10° TPA is less likely to cause patellar ligament strain, but further research is needed for short or long-term outcomes in a live animal canine model is warranted.
Environmental Control on the Productivity of a Heavily Fished Ecosystem
Authors: Cyr Frederic , Adamack Aaron , Bélanger David , Koen-Alonso Mariano , Mullowney Darrell , Murphy Hannah , Regular Paul , Pepin Pierre 
Published: March 2024

Abstract
Sustainable fisheries management requires an understanding of the links between environmental conditions and fish stock populations, especially in the context of climate change. From this perspective, identifying phases where ocean climate fluctuations and changes in ecosystem productivity coincide could provide a powerful tool to help inform fisheries management. Using more than 70 years of climate and fisheries data, this study shows that the Newfoundland and Labrador (NL) ecosystem productivity, from primary producers to piscivorous fish, changes in relative synchronicity with the climate of the northern hemisphere over decadal time scales. Such correspondence between the climate and lower and higher trophic levels has not been achieved previously in the Northwest Atlantic in the context of fisheries. This work advances ideas for incorporating environmental knowledge into fisheries management on the NL shelves, or in other regions facing similar dynamics.
Inter-relation Between Diabetes Mellitus and Hypertension in Terms of Incidence and Prediction: A Retrospective Cohort Study
Authors: Alharbi Abdulhameed , Alharbi Alwaleed , Al-Dubai Sami 
Published: March 2024

Abstract

Background
Hypertension (HTN) and type 2 diabetes mellitus (T2DM) are interconnected metabolic disorders with escalating global incidence and prevalence. However, no longitudinal studies have specifically examined the incidence of HTN and T2DM in the same study population. This study aimed to elucidate the association between HTN and T2DM and ascertain their respective roles in the development of each other.
Methods
This retrospective cohort study encompassed 809 patients from primary healthcare centers in Al Madinah Al Munawarah, Saudi Arabia. The sample was stratified into three cohorts: 226 patients with HTN but without T2DM, 274 patients with T2DM but without HTN, and 309 patients devoid of both T2DM and HTN. Over a retrospective follow-up period of approximately 5 years, incidence density rates (IDR) were computed for HTN in the T2DM cohort, T2DM in the HTN cohort, and both HTN and T2DM in the control cohort. Multiple logistic regression analysis was employed to identify predictors of HTN and T2DM.
Results
The IDR of T2DM among patients with HTN stood at 73.9 (95% confidence interval [CI] 56, 92) per 1000 person-years, in contrast to 33.9 (95% CI 24, 44) per 1000 person-years in the control cohort (adjusted odds ratio [OR] = 7.1, 95% CI 3.55, 14.13). Conversely, the IDR of HTN among patients with type-2 T2DM was 55.9 (95% CI 42, 70) per 1000 person-years, while in the control cohort, it was 20.8 (95% CI 13, 28) per 1000 person-years (adjusted OR = 5.8, 95% CI 3.11, 11.09). Significant predictors of HTN in the logistic regression model encompassed age, smoking status, family history of HTN, T2DM status, and body mass index (BMI). Similarly, significant predictors of T2DM in the logistic regression model included age, sex, family history of T2DM, HTN, and BMI.
Conclusion
This study unveils HTN and T2DM as mutually significant risk factors. The IDR of each condition in the presence of the other significantly exceeded that among individuals devoid of HTN or T2DM.
Optimization of a sensitive and reliable UPLC-MS/MS method to simultaneously quantify almonertinib and HAS-719 and its application to study the interaction with nicardipine
Authors: Chen Dongxin , Chen Jie , Shen Yuxin , Chen Xiaohai , Xia Hailun , Liu Ya-nan , Xu Ren-ai 
Published: March 2024

Abstract
Almonertinib, a novel third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, was selected by the Chinese Society of Clinical Oncology as a first-line therapy for EGFR T790M mutated non-small cell lung cancer in 2021. Almonertinib is primarily metabolized by CYP3A4, so it could interact with a variety of drugs metabolized by CYP3A4, leading to the changes of systemic exposure. For the purpose of this experiment, an ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) assay with accuracy and simplicity was optimized and fully validated for the simultaneous quantitative determination of almonertinib and its metabolite HAS-719, and drug-drug interactions (DDIs) between almonertinib and nicardipine in vivo and in vitro was researched. After one-step precipitation of protein with acetonitrile, chromatographic separations of almonaitinib, HAS-719 and gefitinib (internal standard, IS) were achieved by gradient elution with 0.1% formic acid aqueous solution and acetonitrile. Detection of analytes was achieved by MS/MS coupled with multiple reaction monitoring (MRM) in the positive ion mode with ion transitions of m/z 526.01 → 72.04 for almonertinib, m/z 512.18 → 455.08 for HAS-719, and m/z 447.16 → 128.11 for IS. There was favorable linearity in the 0.5–200 ng/mL calibration range for almonertinib and 0.5–100 ng/mL for HAS-719. The lower limit of quantification (LLOQ) for both analytes were 0.5 ng/mL. The precision, accuracy, stability, matrix effect, and extraction recovery required for methodological validation were consistent with the requirements of FDA guideline. Then, the UPLC-MS/MS assay was employed successfully on the interactions of almonertinib and nicardipine in vivo and in vitro. The half-maximal inhibitory concentration (IC50) was 1.19 µM in rat liver microsomes (RLM), where nicardipine inhibited the metabolism of almonertinib with a mixed inhibitory mechanism. In pharmacokinetic experiments of rats, it was observed that nicardipine could significantly alter the pharmacokinetic profiles of almonertinib, including AUC(0−∞), AUC(0−t) and Cmax, but had no effect on the metabolism of HAS-719. According to the findings, it was indicated that nicardipine could inhibit the metabolism of almonertinib in vitro and in vivo.
Integrating bioinformatics and machine learning methods to analyze diagnostic biomarkers for HBV-induced HCC
Authors: Yang Anyin , Liu Jianping , Li Mengru , Zhang Hong , Zhang Xulei , Wu Lianping 
Published: March 2024

Abstract

Hepatocellular carcinoma (HCC), as a malignant tumor, is expected to become the sixth most commonly diagnosed cancer and the fourth leading cause of cancer-related deaths globally by 2018. It is estimated that approximately 50–80% of HCC cases worldwide are caused by hepatitis b virus (HBV) infection, and other pathogenic factors have been shown to promote the development of HCC when coexisting with HBV. Understanding the molecular mechanisms of HBV-induced hepatocellular carcinoma (HBV-HCC) is crucial for the prevention, diagnosis, and treatment of the disease. In this study, we analyzed the molecular mechanisms of HBV-induced HCC by combining bioinformatics and deep learning methods. Firstly, we collected a gene set related to HBV-HCC from the GEO database, performed differential analysis and WGCNA analysis to identify genes with abnormal expression in tumors and high relevance to tumors. We used three deep learning methods, Lasso, random forest, and SVM, to identify key genes RACGAP1, ECT2, and NDC80. By establishing a diagnostic model, we determined the accuracy of key genes in diagnosing HBV-HCC. In the training set, RACGAP1 (AUC: 0.976), ECT2 (AUC: 0.969), and NDC80 (AUC: 0.976) showed high accuracy. They also exhibited good accuracy in the validation set: RACGAP1 (AUC: 0.878), ECT2 (AUC: 0.731), and NDC80 (AUC: 0.915). The key genes were found to be highly expressed in liver cancer tissues compared to normal liver tissues, and survival analysis indicated that high expression of key genes was associated with poor prognosis in liver cancer patients. This suggests a close relationship between key genes RACGAP1, ECT2, and NDC80 and the occurrence and progression of HBV-HCC. Molecular docking results showed that the key genes could spontaneously bind to the anti-hepatocellular carcinoma drugs Lenvatinib, Regorafenib, and Sorafenib with strong binding activity. Therefore, ECT2, NDC80, and RACGAP1 may serve as potential biomarkers for the diagnosis of HBV-HCC and as targets for the development of targeted therapeutic drugs.
The psychological capital questionnaire for newly licensed nurses: A validity and reliability study
Authors: Jin Man , Wang Jialin , Qian Rong , Yang Huawu , Huang Shuangying , Liao Min , Liu Xu , Liao Dan , Qi Shengwei 
Published: March 2024

Abstract

Background: Newly licensed nurses face great challenges after transitioning from classroom to workplace. As a positive psychological resource, psychological capital can maintain the mental health of nurses. However, there is no instrument dedicated to the psychological capital of new nurses.
Objectives: The present study aimed to evaluate the psychometric properties of psychological capital questionnaire for nurses in newly licensed nurses.
Design: An exploratory, cross-sectional, and methodological design was performed.
Setting: Newly licensed nurses were recruited through convenience sampling from July to October 2023 in Chengdu city, China.
Participants: The study included 357 newly licensed nurses from five tertiary hospitals.
Methods: The general demographic questionnaire, Psychological Capital Questionnaire for Nurses, Utrecht Work Engagement Scale and Compassion Fatigue - Short Scale were used to investigate the newly licensed nurses. The reliability and validity of psychological capital questionnaire for nurses were verified by item analysis, confirmatory factor analysis, correlation test and other statistical methods.
Results: The questionnaire showed a 6-factor structure, namely confidence, hope, resiliency, collaboration communication, responsibility and emotional intelligence, and consisted of 30 items. Item analysis showed that all scores of items were normally distributed. In confirmatory factor analysis, the factor loading of each item ranged from 0.833 to 0.962. The fit indexes of the questionnaire were CMIN/df=3.711, NFI=0.922, IFI=0.941, TLI=0.933, CFI=0.941, RMSEA=0.087. Cronbach’ s alpha of the total scale and six sub-dimension were between 0.738 to 0.880. Besides, the test-retest correlation values of total score and dimensions were found range from 0.529 to 0.631 (P<0.01).
Conclusions: The psychological capital questionnaire for nurses was shown to be a valid and reliable measurement tool using in newly licensed nurses, which was worthy of popularization and next-step study.