bluuebunny/crossref_metadata_2025_split huggingface dataset:
Benzofurans as Acetylcholinesterase Inhibitors for Treating Alzheimer's Disease: Synthesis, in vitro Testing, and in silico Analysis
Authors: Coaviche‐Yoval Arturo , Tovar‐Miranda Ricardo , Rodríguez Jessica E. , Lagos‐Cruz Jesus A. , Luna Héctor , Andrade‐Jorge Erik , Trujillo‐Ferrara José G. 
Published: March 2024

AbstractAlzheimer's disease (AD) is a neurodegenerative disorder and the leading cause of dementia worldwide. It is characterized by a progressive decline in cholinergic neurotransmission. During the development of AD, acetylcholinesterase (AChE) binds to β‐amyloid peptides to form amyloid fibrils, which aggregate into plaque deposits. Meanwhile, tau proteins are hyperphosphorylated, forming neurofibrillary tangles (NFTs) that aggregate into inclusions. These complexes are cytotoxic for the brain, causing impairment of memory, attention, and cognition. AChE inhibitors are the main treatment for AD, but their effect is only palliative. This study aimed to design and synthesize novel benzofuran derivatives and evaluate their inhibition of AChE in vitro and in silico. Results: The seven synthesized benzofuran derivatives inhibited AChE in vitro. Benzofurans hydroxy ester 4, amino ester 5, and amido ester (±)‐7 had the lowest inhibition constant (Ki) values and displayed good affinity for EeAChE in molecular docking. Six derivatives showed competitive inhibition, while the best compound (5: Ki=36.53 μM) exhibited uncompetitive inhibition. The amino, hydroxyl, amide, and ester groups of the ligands favored interaction with the enzyme by hydrogen bonds. Conclusion: Three benzofurans were promising AChE inhibitors with excellent Ki values. In future research on their their application to AD, 5 will be considered as the base structure.
A multi‐primary trichromator to derive individual color matching functions and cone spectral sensitivities
Authors: Shi Keyu , Luo Ming Ronnier , Rider Andrew T. , Huang Tingwei , Xu Lihao , Stockman Andrew 
Published: March 2024

AbstractMeasuring color matching differences between observers is an important means of investigating individual differences in human color vision. In this article, we introduce a new LED‐based visual trichromator with which we have estimated color matching functions and cone spectral sensitivities in a group of five normal observers. The trichromator has side‐by‐side semi‐circular matching fields that are illuminated by two spectrally tunable LED light sources, each comprised of 18 LEDs with center wavelengths ranging from 400 to 700 nm. We used Maxwell's method to derive a set color match. A fixed triplet of red‐green‐blue (RGB) primaries produced the white standard field of 120 cd/m2 in one field. The other field, the mixture field, was illuminated by one of 11 different triplets of lights with various center wavelengths. Observers adjusted the intensities of the triplets in the mixture field to match the white standard field. All matches were made for field diameters of 2° and 10° of visual angle to allow comparisons with colorimetric standards and were repeated five times. Calibrations and tests showed that the trichromator and the measurements were stable and repeatable. Grassmann's laws predict that at the 11 color matches the excitations in the three cone types should be the same. Consequently, we can use those matches and a model of how cone spectral sensitivities vary between individuals to estimate the three underlying corneal cone spectral sensitivities for each observer (and thus how they vary from the standard (or mean) observer). We find good agreement with the CIE 2006 standards, but our observers show small but consistent differences.
Driving corporate social responsibility to be innovative: Insights from a systematic literature review
Authors: Zhao Liming , Yin Chenli 
Published: March 2024

AbstractCorporate social responsibility (CSR) is increasingly under pressure to tackle social and environmental challenges using innovative approaches that benefit both companies and society. This study presents a comprehensive overview of the relevant research on the intersection of CSR and innovation since 1996. Through a bibliometric analysis and literature review of 1362 articles, the study identifies three distinct stages in the evolution of this dual theme: an infancy stage (1996–2005), a rapid growth stage (2006–2015), and an explosive growth stage (2016‐present). By analyzing the studies, subfields, and theories in each stage, we identify the approaches and challenges in CSR innovation research. Notably, digital organizational culture, sensitivity analysis, and social enterprise have emerged as current major concerns, while sustainable development and analysis methods have emerged as challenges in addressing CSR innovation. Based on these findings, we propose several future research opportunities for CSR innovation research.
ThyroSeq overview on indeterminate thyroid nodules: An institutional experience
Authors: Sirotnikov Sam , Griffith Christopher C. , Lubin Daniel , Zhang Chao , Saba Nabil F. , Li Dehong , Kornfield Amanda , Chen Amy , Shi Qiuying 
Published: March 2024

AbstractBackgroundMolecular triage of indeterminate thyroid aspirates offers the opportunity to stratify the risk of malignancy (ROM) more accurately. Here we examine our experience with ThyroSeq v3 testing.MethodsWe analyzed 276 of 658 (42%) fine needle aspiration samples classified as indeterminate thyroid nodules using ThyroSeq v3 (Sept 2017–Dec 2019). The test provides a ROM and detects specific mutations. Surgical diagnoses were reviewed.ResultsOf 276 ThyroSeq‐tested cases, 42% (n = 116) harbored genetic alterations, whereas 64% (n = 74) had surgical follow‐up. Notably, 79% cases within intermediate to higher risk mutations were highly associated with surgical intervention, resulting in a 77.5% ROM when including both cancer and noninvasive follicular thyroid neoplasia with papillary‐like features (cancer+NIFTP) and 68% malignant diagnosis when excluding NIFTP. RAS‐like alterations were most common (66%), exhibiting a 73.4% ROM and a 59% malignant diagnosis. Interestingly, this group included 24 encapsulated follicular variant papillary thyroid carcinomas (EFVPTCs), 1 infiltrative FVPTC, 9 follicular carcinomas, and 7 NIFTP. Additionally, three high‐risk mutations and eight BRAF/V600E mutations had a 100% ROM, all diagnosed as classic‐type papillary thyroid carcinoma (cPTC). Combined analysis of thyroid nodules from Bethesda III and IV categories revealed a 78.2% positive predictive value (PPV) and a 75.9% negative predictive value (NPV).ConclusionThyroSeq v3 effectively stratifies the ROM in indeterminate thyroid nodules based on specific genetic alterations, guiding appropriate surgical management. Notably, the BRAFV600E/high‐risk group and RAS‐like groups exhibited ROM of 100% and 77.5%, respectively, with promising predictive accuracy (PPV of 78.2% and NPV of 75.9%).
Relationship between site resonance frequency and bedrock interface at one‐dimensional sites based on the KiK‐net database
Authors: Kong Xiaoshan , Rong Mianshui , Li Xiaojun , Wang Jixin , Zhang Bin 
Published: March 2024

AbstractSite resonance frequency is a crucial parameter for estimating site effects. However, there is currently no consensus on how to identify the bedrock interface to obtain the site resonance frequency. In this study, we identified 43 stations that can be regarded as one‐dimensional sites from the KiK‐net network in Japan, which consists of 699 stations. By analyzing the horizontal‐to‐vertical spectral ratio and surface‐to‐borehole spectral ratio of strong motion observation recordings, the fundamental resonance frequency (f0) of these 43 sites was determined. Subsequently, the correlation between the f0 values obtained from theoretical noise horizontal‐to‐vertical spectral ratio (NHV) with different bedrock interfaces and the f0 values determined from observation was analyzed. The conclusion shows that the f0 is primarily influenced by shallow interfaces with high S‐wave impedance contrasts (ICs). Specifically, when the bedrock interface is taken as the interface with ICs greater than 2.5 that appears for the first time, or the interface with ICs greater than 1.5 that appears for the second time, there is a strong correlation (greater than 0.86) between the f0 values obtained from theoretical NHV and from observation. These findings can provide a quantitative reference for accurately determining the fundamental resonance frequency.
Experimental model updating of slope considering spatially varying soil properties and dynamic loading
Authors: Wang Ruohan , Ouyang Jiayi , Fragkoulis Vasileios C. , Liu Yong , Beer Michael 
Published: March 2024

AbstractThe widespread threat posed by slope structure failures to human lives and property safety is widely acknowledged. Additionally, natural soil often displays spatial variability due to geological deposition and other factors. Therefore, predicting the seismic response of slopes subjected to ground motions and inversely analyzing the spatial distribution of soils remains an unresolved issue. In the present work, a shaking table experimental test is first designed and carried out, in which a soft‐soil slope dynamic system is established. To capture the seismic response of the soft‐soil slope, specifically the experimental characteristic of acceleration and soil pressure response in both spatial domain and time domain, a series of sensors were pre‐embedded in the slope. Subsequently, a model updating approach is proposed for slope seismic analysis that incorporates spatial variability of soil. In addition, to enhance computational efficiency, the dimensionality reduction of Karhunen–Loève expansion method is introduced to reduce inverse analysis parameters. On the basis of 34 samples collected from experimental data, it is shown that near‐fault pulse‐like ground motions deliver greater concentrated energy, causing more severe damage to slope structures, especially the topsoil layer. Furthermore, using data obtained from a shaking table test subjected to ground motion Recorded Sequence Number 158H1 from the Pacific Earthquake Engineering Research Center NGA‐West2 database as an example, it is also shown that the proposed approach demonstrates high accuracy in predicting the spatial distribution of the maximum shear modulus in soil slope dynamic systems. The present work not only addresses the challenges posed by mainshock–aftershock effects but also highlights the potential of model updating approaches to enhance the understanding of slope behavior under seismic loading conditions.
Evaluating the identification methods of permanent displacement derived from strong motion records: Case studies in the 2023 Turkey–Syria earthquake
Authors: Zhou Baofeng , Guo Wenxuan , Ren Yefei , Wen Ruizhi , Wang Hongwei , Xu Tong , Zhang Cong , Liu Aiwen 
Published: March 2024

AbstractOn February 6, 2023, the Republic of Turkey experienced a rare occurrence of two successive earthquakes, each with a magnitude exceeding 7.0. The Disaster and Emergency Management Agency (AFAD) swiftly shared the strong motion records, thereby enriching the global database of near‐fault strong motion records. Identification of permanent displacement is essential for effectively utilizing these records. In this study, we refined the permanent displacement identification method, which combines the Hermit interpolation baseline correction with flatness determination by incorporating a low‐pass filter. Following this, we compared four permanent displacement identification methods, including our improved approach. We applied these to the strong motion record of station 4404 and compared the results with the Global Positioning System coseismic displacement. At the same time, we used field investigation data to verify the effectiveness of our improved method, studying its applicability for both single‐wave packet and multiwave packet records. The conclusions are the following: the improved method provides a more reasonable and effective means of identifying permanent displacement. When the peak ground acceleration (PGA) exceeds 1 g, the permanent displacement identifications from the four methods differ significantly. The discrepancy in permanent displacements identified by the four methods in the horizontal direction is larger than that in the U−D direction. For the record with the largest PGA (station 4614), our improved method yields more reasonable results compared with other techniques. Furthermore, the choice of segmentation time nodes in the velocity time history significantly affects the identification of permanent displacement.
Comparative analysis of nondimensionalization approaches for solving the 2‐D differentially heated cavity problem
Authors: Molina‐Herrera F. I. , Quemada‐Villagómez L. I. , Navarrete‐Bolaños J. L. , Jiménez‐Islas H. 
Published: March 2024

AbstractThis work reports a numerical study on the effect of three nondimensionalization approaches that are commonly used to solve the classic problem of the 2‐D differentially heated cavity. The governing equations were discretized using orthogonal collocation with Legendre polynomials, and the resulting algebraic system was solved via Newton–Raphson method with LU factorization. The simulations were performed for Rayleigh numbers between 103 and 108, considering the Prandtl number equal to 0.71 and a geometric aspect ratio equal to 1, analyzing the convergence and the computation time on the flow lines, isotherms and the Nusselt number. The mesh size that provides independent results was 51 × 51. Approach II was the most suitable for the nondimensionalization of the differentially heated cavity problem.
The influence of ripening on the nutrient composition and antioxidant properties of New Zealand damson plums
Authors: Rashidinejad Ali , Ahmmed Mirja Kaizer 
Published: March 2024

AbstractThe current study pioneers a comprehensive exploration into the influence of ripening stages on the nutritional composition and antioxidant attributes of the New Zealand damson plums (Prunus domestica ssp. Insititia). Sampled at early‐, mid‐, and late‐ripening stages from randomly selected plum trees, the investigation unveiled notable significant (p < .05) declines in multiple parameters as ripening progressed. Noteworthy reductions in dry matter (from 21% to 19.33%), stone weight (from 30.23% to 24.30%), total dietary fiber (from 3.15% to 2.5%), energy content (from 280 to 263 kJ/100 g), vitamin D3 (from 1.67 to 1.53 μg/100 g), vitamin A (from 4.2 to 3.87 μg/100 g), and specific minerals (e.g., Ca, Mg, and P) emerged as a hallmark of this progression. Additionally, plums harvested at the advanced ripening stage exhibited heightened moisture content in contrast to their early‐stage counterparts. Conversely, ash, protein, carbohydrates, total sugar, and minerals (including K, Na, Zn, and Se) demonstrated no significant alteration (p > .05) across ripening stages. Remarkably, damson plums that were harvested at the end of the ripening stage displayed reduced phenolic content and total antioxidant activity compared to those acquired at the early–mid ripening phase. This research collectively highlights the substantive impact of harvesting time and ripening stage on the nutritional and antioxidant profiles of damson plums cultivated in New Zealand.
Small vessel disease and cognitive reserve oppositely modulate global network redundancy and cognitive function: A study in middle‐to‐old aged community participants
Authors: Cui Lei , Hong Hui , Wang Shuyue , Zeng Qingze , Jiaerken Yeerfan , Yu Xinfeng , Zhang Ruiting , Zhang Yao , Xie Linyun , Lin Miao , Liu Lingyun , Luo Xiao , Li Kaicheng , Liu Xiaocao , Li Jixuan , Huang Peiyu , Zhang Minming 
Published: March 2024

AbstractCerebral small vessel disease (SVD) can disrupt the global brain network and lead to cognitive impairment. Conversely, cognitive reserve (CR) can improve one's cognitive ability to handle damaging effects like SVD, partly by optimizing the brain network's organization. Understanding how SVD and CR collectively influence brain networks could be instrumental in preventing cognitive impairment. Recently, brain redundancy has emerged as a critical network protective metric, providing a nuanced perspective of changes in network organization. However, it remains unclear how SVD and CR affect global redundancy and subsequently cognitive function. Here, we included 121 community‐dwelling participants who underwent neuropsychological assessments and a multimodal MRI examination. We visually examined common SVD imaging markers and assessed lifespan CR using the Cognitive Reserve Index Questionnaire. We quantified the global redundancy index (RI) based on the dynamic functional connectome. We then conducted multiple linear regressions to explore the specific cognitive domains related to RI and the associations of RI with SVD and CR. We also conducted mediation analyses to explore whether RI mediated the relationships between SVD, CR, and cognition. We found negative correlations of RI with the presence of microbleeds (MBs) and the SVD total score, and a positive correlation of RI with leisure activity‐related CR (CRI‐leisure). RI was positively correlated with memory and fully mediated the relationships between the MBs, CRI‐leisure, and memory. Our study highlights the potential benefits of promoting leisure activities and keeping brain redundancy for memory preservation in older adults, especially those with SVD.
Conscientiousness and perceived ethicality: Examining why hierarchy of authority diminishes this positive relationship
Authors: Luksyte Aleksandra , Carpini Joseph A. , Parker Sharon K. , Griffin Mark A. 
Published: March 2024

AbstractHuman resource (HR) managers hire conscientious employees because they are both productive and are viewed as upholding high ethical standards due to their propensity to engage in voice. Organizations may strive to create a work context conducive to all employees acting ethically, not just conscientious ones, by centralizing decision‐making authority and promoting formalization through a higher hierarchy of authority. Yet, we propose that from the social information processing perspective, in higher hierarchy of authority contexts, peers may view their highly conscientious colleagues as less ethical. We hypothesize these effects through the lens of trait activation theory, according to which in a higher hierarchy of authority context, others are less likely to notice the voice behaviors of conscientious employees. Problematically, when others fail to notice conscientious employees' voice, they may perceive these workers as being less ethical. We tested our hypothesized moderated mediation model in a matched sample of employees (N = 820), their supervisors (N = 445), and peers (N = 529). As predicted, hierarchy of authority moderated the positive relationship between conscientiousness and voice, which in turn explained others' perceptions of their ethicality. Conscientiousness was positively related to peer assessments of ethicality via promotive (not prohibitive) voice when hierarchy of authority was lower (but not higher), partially supporting our hypotheses. These results suggest HR practitioners should be cognizant of the differential evaluations of highly conscientious employees in contexts with different levels of hierarchy of authority, and continuing challenges associated with balancing flexibility and formalization.
Research progress on the relationship between traumatic brain injury and brain‐gut‐microbial axis
Authors: Yu Jie , Chen Yun‐Xin , Wang Jin‐Wei , Wu Hai‐Tao 
Published: March 2024

AbstractTraumatic brain injury (TBI) is a common disease with a high rate of death and disability, which poses a serious threat to human health; thus, the effective treatment of TBI has been a high priority. The brain‐gut‐microbial (BGM) axis, as a bidirectional communication network for information exchange between the brain and gut, plays a crucial role in neurological diseases. This article comprehensively explores the interrelationship between the BGM axis and TBI, including its physiological effects, basic pathophysiology, and potential therapeutic strategies. It highlights how the bidirectional regulatory pathways of the BGM axis could provide new insights into clinical TBI treatment and underscores the necessity for advanced research and development of innovative clinical treatments for TBI.
Use of 5‐alpha reductase inhibitors and risk of gastrointestinal cancers in men with benign prostatic hyperplasia: A population‐based cohort study
Authors: Doherty Niamh , Cardwell Chris , Murchie Peter , Hill Christopher , Azoulay Laurent , Hicks Blánaid 
Published: March 2024

AbstractPre‐clinical evidence suggests that 5‐alpha reductase inhibitors (5ARi's), prescribed in the treatment of benign prostatic hyperplasia, reduce colorectal and gastro‐oesophageal cancer incidence via action on the male hormonal pathway. However, few studies to date have investigated this association at the population level. Our study aimed to investigate the risk of colorectal and gastro‐oesophageal cancers with the use of 5ARi's. We conducted a retrospective cohort study of new users of 5ARi's and alpha‐blockers among patients with benign prostatic hyperplasia in the UK Clinical Practice Research Datalink. Patients were followed until a first ever diagnosis of colorectal or gastro‐oesophageal cancer, death from any cause or end of registration with the general practice or 31st of December 2017. Cox proportional hazards models with inverse probability of treatment weights were used to calculate weighted hazard ratios (HR) and 95% confidence intervals (CIs) of incident colorectal cancer or gastro‐oesophageal cancer associated with the use of 5ARi's compared to alpha‐blockers. During a mean follow‐up of 6.6 years, we found no association between the use of 5ARi's and colorectal (HR: 1.13, 95% CI 0.91–1.41) or gastro‐oesophageal (HR 1.14, 95% CI 0.76–1.63) cancer risk compared to alpha‐blockers. Sensitivity analysis showed largely consistent results when varying lag periods, using multiple imputations, and accounting for competing risk of death. Our study found no association between the use of 5ARi's and risk of colorectal or gastro‐oesophageal cancer in men with benign prostatic hyperplasia.