bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis and Biological Evaluation of Novel Pyrazolo[4,3‐b]oleanane Derivatives as Inhibitors of Glycogen Phosphorylase
Authors: Chen Jun , Gong Yanchun , Liu Jun , Hua Weiyi , Zhang Luyong , Sun Hongbin 
Published: July 2008

AbstractEighteen pyrazolo[4,3‐b]oleanane derivatives have been synthesized and biologically evaluated as inhibitors of rabbit muscle GPa. Key compound 5 was readily obtained in four steps starting from oleanolic acid (OA; 1). Further modification based on pyrazolo triterpene 5 resulted in 17 novel pyrazolo pentacyclic triterpenes. All of the synthesized pyrazolo[4,3‐b]oleanane derivatives were biologically assayed against rabbit muscle GPa. Within this series of compounds, pyrazole triterpene 19 (IC50=9.9 μM) exhibited more potent activity than the parent compound 1. Preliminary structure–activity relationship analysis of the pyrazolo[4,3‐b]oleanane derivatives as GPa inhibitors is discussed.
Evaluation of Organophosphorus Chemicals‐Degrading Enzymes: A Comparison of Escherichia coli and Human Cytosolic Aminopeptidase P
Authors: Hsu Yu‐Ting , Su Chiao‐Yung , Du Huang‐Chi , Jao Shu‐Chuan , Li Wen‐Shan 
Published: July 2008

AbstractAn enzyme capable of hydrolyzing organophosphate compounds is of biological as well as environmental significance. We evaluated the possibility of human cytosolic aminopeptidase P (hcAMPP) as an attractive bioscavenger candidate by measuring the enzymatic rates of hydrolysis for a wide variety of organophosphorus compounds. The comparison of substrate specificity exhibited by hcAMPP and E. coli aminopeptidase P (E. coli AMPP) was studied.We cloned, expressed, and purified hcAMPP from HeLa cells and AMPP from Escherichia coli. The pH‐rate profiles of hcAMPP were measured in the presence of organophosphate compound 3 or 5. All of the organophosphorus compounds, 1–19, were synthesized by using the approach of phosphorus chemistry described in a previous publication. The relative activity of hcAMPP and E. coli AMPP in hydrolyzing a series of organophosphorus analogues, 1–17, was evaluated in a spectrophotometric assay by monitoring the difference of accumulation of 4‐nitrophenol at 400 nm.The overall substrate preference of hcAMPP is as follows: methylphosphonates>ethylphosphonates≥organophosphates. Interestingly, the observed enhancement in the activity of hcAMPP with methyl phosphonates, 8, 10, 12, and 13, suggests that there is particularly special about the substructure of both methyl moiety and PO ligand, since the values of specific activity with hcAMPP for the methylphosphonates 8, 10, 12, and 13 are 2‐ to 73‐fold greater than those for the ethylphosphonates 14–17 and the organophosphates 1–7. Similarly, in E. coli AMPP toward ethylphosphonates 14–17, the results indicate that the regions of both MeO moiety and PO ligand may be located in the vicinity of the substrate‐binding site, which have not been altered within the active site of enzyme upon mutation of Trp88, Arg153, and Arg370.These studies demonstrate that E. coli AMPP and hcAMPP display different substrate preference toward organophosphorus compounds. Evidence here, therefore, represents the first example of hcAMPP that might serve as a valuable bioscavenger candidate as E. coli AMPP due to the promise from the hydrolysis of these toxic chemicals.
Argusides D and E, Two New Cytotoxic Triterpene Glycosides from the Sea Cucumber Bohadschia argusJaeger
Authors: Liu Bao‐Shu , Yi Yang‐Hua , Li Ling , Sun Peng , Han Hua , Sun Guo‐Quan , Wang Xiao‐Hua , Wang Zeng‐Lei 
Published: July 2008

AbstractTwo new triterpene glycosides, argusides D and E (1 and 2, resp.), have been isolated from the sea cucumber Bohadschia argus Jaeger collected in the South China Sea. Their structures have been established by spectral analysis (ESI‐MS, and 1D‐ and 2D‐NMR) and chemical evidence. Compounds 1 and 2 both possess an holostane‐type triterpene aglycone with a C(9)C(11) bond, an OH group at C(12), and tetrasaccharide moieties, but differ in the side chains. The two glycosides exhibited significant cytotoxicities against four human tumor cell lines, A549, HCT‐116, HepG2, and MCF‐7.
Distal myocardial protection with intracoronary beta blocker when added to a Gp IIb/IIIa platelet receptor blocker during percutaneous coronary intervention improves clinical outcome
Authors: Uretsky Barry F. , Birnbaum Yochai , Osman Abdulfatah , Gupta Rajiv , Paniagua Oscar , Chamoun Antonio , Pohwani Amir , Lui Charles , Lev Eli , McGehee Todd , Kumar Darren , Akhtar Asif , Anzuini Angelo , Schwarz Ernst R. , Wang Fen Wei 
Published: July 2008

AbstractObjective: The present study tested the hypothesis that intracoronary (IC) propranolol improves clinical outcomes with percutaneous coronary intervention (PCI) when used with background Gp IIb/IIIa receptor blockade. Background: We have previously shown that administration of a relatively large weight‐based IC dose of the beta blocker propranolol before PCI decreases the incidence of post‐PCI myocardial infarction (MI) and improves short‐ and long‐term outcome. It has previously been shown that administration of a Gp IIb/IIIa receptor blocker decreases post‐PCI MI and improves short‐ and long‐term clinical outcome. Methods: Patients undergoing PCI (n = 400) were randomized in a prospective double‐blind fashion to IC propranolol (n = 200) or placebo (n = 200) with eptifibatide administered to all the patients. Myocardial isoform of creatine kinase was measured during the first 24 hr and clinical outcomes at 30 days and 1 year. Results: MI after PCI was seen in 21.5% of placebo and 12.5% of propranolol patients (relative risk reduction 0.42; 95%CI 0.09, 0.63; P = 0.016). At 30 days, the composite end point of death, post‐procedural MI, urgent target lesion revascularization, or MI after index hospitalization occurred in 22.5% of placebo vs. 13.5% of propranolol patients (risk reduction 0.43; 95%CI 0.08, 0.65; P = 0.018). Similar results were observed at 1 year with adverse outcomes in 21.5% of propranolol and 32.5% of placebo patients (P = 0.01). Conclusion: IC propranolol administration with the background Gp IIb/IIIa receptor blockade significantly reduces the incidence of post‐PCI MI and improves the short‐ and long‐term clinical outcome when compared with a Gp IIb/IIIa blocker alone. © 2008 Wiley‐Liss, Inc.
Transradial versus transfemoral approach for coronary angiography and intervention in patients above 75 years of age
Authors: Achenbach Stephan , Ropers Dieter , Kallert Lisa , Turan Nesrin , Krähner Robert , Wolf Tobias , Garlichs Christoph , Flachskampf Frank , Daniel Werner G. , Ludwig Josef 
Published: July 2008

AbstractAims: The transradial (TR) approach has potentially lower complication rates than transfemoral (TF) approach coronary angiography. However, it may be technically more challenging, especially in elderly patients with alterations in vascular anatomy. We thus determined success rates, procedural data, and complication rates of TR angiography in comparison to the TF approach in elderly patients in a randomized, prospective trial. Methods and results: Four hundred consecutive patients ≥75 years with known or suspected coronary artery disease were included in the study. After exclusion of 93 patients with contraindications to the radial approach, 152 patients were randomized to the TR and 155 to TF coronary angiography and intervention. In 13 patients randomized to TR, cross‐over to TF was necessary (9%). Total examination time was significantly longer for the TR approach (18.1 vs. 15.0 min, P = 0.009), but no difference was found for fluoroscopy time, number of catheters used, or amount of contrast agent. The rate of major complications (bleeding requiring surgery or transfusion, stroke) was 0% for TR and 3.2% for TF approach (P < 0.001). Minor complications occurred in 1.3% versus 5.8% of patients (P < 0.001). Conclusion: In elderly patients, TR coronary angiography and intervention has a high technical success rate and lower complication rates than the TF approach. © 2008 Wiley‐Liss, Inc.
The off‐ versus on‐label use of medical devices in interventional cardiovascular medicine: Clarifying the ambiguity between regulatory labeling and clinical decision‐making, Part 1: PCI
Authors: Price Matthew J. , Teirstein Paul S. 
Published: July 2008

AbstractThe Food and Drug Administration convened a special public meeting of the Circulatory System Devices Advisory Panel in late 2006 in response to data suggesting a small but potentially significant increased risk of stent thrombosis with drug‐eluting stents (DES). This panel concluded that “off‐label” DES use was associated with an increased risk of adverse outcomes compared with “on‐label” use. In this commentary, we will discuss the role of product labeling in clinical decision‐making during percutaneous coronary intervention, elucidate the issues that may arise from the conflation of the responsibilities of regulatory bodies and physicians, and offer a potential framework for their resolution. © 2008 Wiley‐Liss, Inc.
Left ventricular unloading with intra‐aortic counter pulsation prior to reperfusion reduces myocardial release of endothelin‐1 and decreases infarction size in a porcine ischemia‐reperfusion model
Authors: LeDoux John F. , Tamareille Sophie , Felli Patty R. , Amirian James , Smalling Richard W. 
Published: July 2008

AbstractObjectives:We tested the hypothesis that unloading the left ventricle with intra‐aortic balloon counter‐pulsation just prior to reperfusion provides infarct salvage compared with left ventricular (LV) unloading postreperfusion or reperfusion alone.Background:Previous reports demonstrated infarct salvage with complete LV unloading with an LVAD prior to reperfusion; however, partial LV unloading using intra‐aortic balloon pumps (IABPs) has not been evaluated.Methods:Twenty‐eight Yorkshire pigs were subjected to 1 hr of left anterior descending artery occlusion and 4 hr of reperfusion. An IABP was inserted and activated just prior to reperfusion (IABP‐Pre), or 15 min after reperfusion (IABP‐Post), or not at all (control).Results:At baseline, the hemodynamic data were similar in the three groups. Myocardial infarct size expressed a percentage of zone at risk in control animals was 44.9% ± 4.8%, IAPB‐Pre group 20.9% ± 5.1% (P < 0.05 compared to control), and IABP‐Post group 33.2 ± 6.1% (P = 0.16 vs. control group). There was a correlation between transcardiac endothelin‐1 release at 15 min postreperfusion and infarct size (r = 0.59).Conclusion:LV unloading with an IABP prior to reperfusion reduces the extent of myocardial necrosis in hearts subjected to 1 hr of left anterior descending artery occlusion and 4 hr of reperfusion compared with either reperfusion alone or LV unloading after reperfusion. Inhibition of myocardial ET‐1 release by LV unloading may be a significant mechanism of myocardial protection. These data suggest that in high‐risk STEMI patients, IABP unloading prior to reperfusion might be more beneficial than IABP placement postreperfusion. © 2008 Wiley‐Liss, Inc.
Comparison of sirolimus‐eluting stent and paclitaxel‐eluting stent for long‐term cardiac adverse events in diabetic patients: The Korean multicenter angioplasty team (KOMATE) registry
Authors: Kim Jung‐Sun , Lee Byoung Ho , Ko Young‐Guk , Choi Donghoon , Jang Yangsoo , Min Pil‐Ki , Yoon Young‐Won , Hong Bum Kee , Kwon Hyuck Moon , Ahn Min‐Soo , Lee Seung‐Hwan , Yoon Jung Han , Lee Byoung Kwon , Kim Byung Ok , Kim Byeong‐Kuk , Oh Sung Jin , Jeon Dong Woon , Yang Joo Young , Cho Jung Rae , Jung Jae‐Hun , Ryu Seung‐Ki 
Published: July 2008

AbstractBackground: There is some controversy on long‐term cardiac outcomes between sirolimus‐eluting stents (SES) and paclitaxel‐eluting stents (PES) in diabetes mellitus (DM). We compared cardiac adverse events after SES and PES implantation in patients with DM over a period of 3 year. Methods: A total of 634 patients with DM treated with SES (n = 428) or PES (n = 206) were consecutively enrolled in the KOMATE registry from 2003 to 2004. We assessed major adverse cardiac events (MACEs, cardiovascular death, nonfatal myocardial infarction, ischemia driven target vessel revascularization) and stent thrombosis (ST) according to the definitions set by the Academic Research Consortium. Results: Propensity score (PS) analysis was performed to adjust different baseline characteristics. The mean follow‐up duration was 38 ± 8 month (at least 36 month and up to 53 month). The 3‐year MACE rate did not show a significant difference between the two groups [52 (12.1%) in SES vs. 29 (14.1%) in PES, P = 0.496]. The definite and probable ST at 3 year were similar in both SES and PES [12 (2.8%) in SES vs. 7 (3.4%) in PES, P = 0.681]. There were no differences in hazard ratio for MACE and ST between two stents [MACE, crude: 0.844 (0.536–1.330) and adjusted for PS: 0.858 (0.530–1.389); ST, crude: 0.820 (0.323–2.083) and adjusted for PS: 0.960 (0.357–2.587)]. Conclusions: The present study demonstrated that long‐tem cardiac outcomes including ST were not significantly different between SES and PES in patients with DM. © 2008 Wiley‐Liss, Inc.
Feasibility and efficacy of stent redilatation in aortic coarctation
Authors: Zanjani Keyhan S. , Sabi Titus , Moysich Axel , Ovroutski Stanislav , Peters Bjoern , Miera Oliver , Kühne Titus , Nagdyman Nicole , Berger Felix , Ewert Peter 
Published: July 2008

AbstractObjectives: We evaluated the efficacy and safety of stent redilation in patients with aortic coarctation (COA). Methods and Results: In our retrospective study of 28 stent redilation procedures on 22 patients, the interval between implantation and redilation ranged from 2.5 month to 11 years (median 18 months). Ten patients had native COAs, one had repaired interrupted aortic arch. The remaining patients had residual COAs after surgery. Stent redilation was successful in 26 procedures. Pressure gradients decreased from a mean of 26 ± 13.8 mm Hg to 7.9 ± 6.52 mm Hg (P < 0.001). The mean diameter of the stents increased from 9.19 ± 3.29 mm to 12.1 ± 3.68 mm (P < 0.001). In a patient with Williams‐Beuren syndrome, massive neointimal proliferation made stent redilation impossible. One other patient developed aortic aneurysm after redilation and was operated after 3 years. Conclusions: Stent redilation for aortic COA is a safe and successful procedure. © 2008 Wiley‐Liss, Inc.
The off‐versus on‐label use of medical devices in interventional cardiovascular medicine?: Clarifying the ambiguity between regulatory labeling and clinical decision making, Part III: Structural heart disease interventions
Authors: Holzer Ralf , Hijazi Ziyad 
Published: July 2008

AbstractThe majority of devices used to treat congenital cardiac lesions in the cardiac catheterization laboratory are used on an off‐label basis. This article discusses the predicaments faced by the interventional cardiologist when implanting devices on an off‐label basis, using procedural examples of PFO closure and endovascular stent placement. Strategies that may benefit patient and provider, as well as satisfying regulatory agencies are suggested. © 2008 Wiley‐Liss, Inc.
Comparison between ticlopidine and clopidogrel in patients undergoing primary stenting in acute myocardial infarction: Results from the CADILLAC trial
Authors: Lansky Alexandra J. , Tsuchiya Yoshihiro , Brener Micheal , Mehran Roxana , Cristea Ecaterina , Pietras Cody , Grines Cindy L. , Cox David A. , Garcia Eulogio , Tcheng James E. , Guagliumi Giulio , Stuckey Thomas , Turco Mark , Carroll John D. , Rutherford Barry D. , Leon Martin B. , Moses Jeffrey , Stone Gregg W. 
Published: July 2008

AbstractObjective:The aim of this article is to examine whether clopidogrel and ticlopidine treatments produce similar clinical outcomes for patients receiving primary stenting for acute myocardial infarction (AMI).Background:Prior studies have yielded conflicting results on the relative safety and efficacy of clopidogrel and ticlopidine after stent implantation, warranting an evaluation in primary stenting for AMI.Methods:In the multicenter, prospective CADILLAC trial, patients undergoing primary infarct stenting were treated at operator discretion with either ticlopidine (931 patients) or clopidogrel (163 patients) and then followed for 1 year. Baseline clinical and angiographic characteristics were comparable except for baseline TIMI 0/1 flow (72.5% clopidogrel vs. 63.9% ticlopidine, P = 0.04).Results:Patients receiving clopidogrel had more recurrent ischemia in hospital (6.1 vs. 2.8%, P = 0.02) and at 30 days (10.5 vs. 5.8%, P = 0.02), more moderate and severe bleeding at 30 days (7.4 vs. 2.7%, P = 0.002), and similar rates of stent thrombosis out to 1 year (P = 0.11). By multivariable analysis, clopidogrel use was an independent predictor for recurrent ischemia in hospital (P = 0.0002), and at 30 days (P = 0.012); and of moderate and severe bleeding in hospital (P = 0.002), and at 30 days (P = 0.001).Conclusions:Despite thienopyridines similarities, their efficacy may be different within the first 30 days of primary stenting for AMI. A prospective, randomized trial is required to confirm these findings. © 2008 Wiley‐Liss, Inc.
ChemInform Abstract: Equilibrium Structure and Torsional Barrier of BH3NH3.
Authors: Demaison Jean , Lievin Jacques , Csaszar Attila G. , Gutle Claudine 
Published: July 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Superconductivity at 43 K in an Iron‐Based Layered Compound LaO1‐xFxFeAs.
Authors: Takahashi Hiroki , Igawa Kazumi , Arii Kazunobu , Kamihara Yoichi , Hirano Masahiro , Hosono Hideo 
Published: July 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Small Neutral Molecule with Two Noble‐Gas Atoms: HXeOXeH.
Authors: Khriachtchev Leonid , Isokoski Karoliina , Cohen Arik , Raesaenen Markku , Gerber R. Benny 
Published: July 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: YF[MoO4] and YCl[MoO4]: Two Halide Derivatives of Yttrium ortho‐Oxomolybdate: Syntheses, Structures, and Luminescence Properties.
Authors: Schleid Thomas , Strobel Sabine , Dorhout Peter K. , Nockemann Peter , Binnemans Koen , Hartenbach Ingo 
Published: July 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Solution Dynamics and Gas‐Phase Chemistry of Pd2@Sn4‐18.
Authors: Kocak F. Sanem , Zavalij Peter , Lam Yiu‐Fai , Eichhorn Bryan W. 
Published: July 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Methyl‐α‐D‐glucopyranoside‐Based Azacrown Ethers and Their Application in Enantioselective Reactions.
Authors: Mako Attila , Szoelloesy Aron , Keglevich Gyoergy , Menyhard Dora K. , Bako Peter , Toeke Laszlo 
Published: July 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Direct Substitution of the Hydroxy Group at the Allylic/Propargylic Position with Carbon‐ and Heteroatom‐Centered Nucleophiles Catalyzed by Yb(OTf)3.
Authors: Huang Wen , Shen Quan‐Sheng , Wang Jia‐Liang , Zhou Xi‐Geng 
Published: July 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: [8 + 2] and [8 + 3] Cyclization Reactions of Alkenyl Carbenes and 8‐Azaheptafulvenes: Direct Access to Tetrahydro‐1‐azaazulene and Cyclohepta[b]pyridinone Derivatives.
Authors: Barluenga Jose , Garcia‐Rodriguez Jaime , Martinez Silvia , Suarez‐Sobrino Angel L. , Tomas Miguel 
Published: July 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis, Antitubercular and Antimicrobial Activities of Some New Pyrazoline and Isoxazole Derivatives.
Authors: Vyas D. H. , Tala S. D. , Dhaduk M. F. , Akbari J. D. , Joshi H. S. 
Published: July 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and QSAR Studies of Thiosemicarbazides, 1,2,4‐Triazoles, 1,3,4‐Thiadiazoles and 1,3,4‐Oxadiazoles Derivatives as Potential Antibacterial Agents.
Authors: Desai N. C. , Bhavsar A. M. , Shah M. D. , Saxena Anil K. 
Published: July 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Selective Oxidation of Organic Compounds Using Pyridinium‐1‐sulfonate Fluorochromate, C5H5NSO3H [CrO3F] (PSFC).
Authors: Bekhradnia Ahmad R. , Zahir Forohe , Arshadi Sattar 
Published: July 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Facile and Convenient Method for the Conversion of Thioamides into Amides Using Pyridinium Hydrobromide Perbromide.
Authors: Lakouraj Moslem M. , Ghodrati Keivan 
Published: July 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.