bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcome of Laparoscopic Versus Vaginal High Uterosacral Ligament Vault Suspension at the Time of Hysterectomy
Authors: Vereeck Sascha , Alexander James , Carey Michael , Rosamilia Anna 
Published: February 2025

Abstract

Introduction and Hypothesis
High uterosacral ligament suspension (HUSLS) can be used to treat apical pelvic organ prolapse (POP). This can be performed both vaginally and laparoscopically. Data comparing the two suspension procedures remain limited. The aim of this study is to compare the effectiveness and safety of vaginal HUSLS and laparoscopic HUSLS at the time of hysterectomy.

Methods
This is a retrospective cohort study of women who underwent hysterectomy between 2019 and 2021 at a tertiary urogynaecology unit. Either vaginal or laparoscopic hysterectomy was performed, followed by vaginal or laparoscopic HUSLS respectively. Women were followed up at 6 weeks, and at 6 and 12 months postoperatively. The primary outcome was symptomatic recurrence of vaginal bulge symptoms. Secondary outcomes were anatomical recurrence, re-treatment and safety.

Results
A total of 111 women met the inclusion criteria. Twelve were excluded, leaving 99 for analysis. HUSLS was performed vaginally in 47 and laparoscopically in 52 women. There was no significant difference in demographics between the groups. At 12 months, 92% in the vaginal group and 48% of the laparoscopic group reported no symptoms of prolapse, 67% vs 36% had no anatomical recurrence and 0% vs 34% had re-treatment respectively. Logistic regression (adjusting for age, BMI, menopausal status, preoperative stage apical prolapse, procedure type) demonstrated that the laparoscopic route was the only variable associated with recurrent prolapse at or beyond the hymen and symptomatic prolapse at 12 months.

Conclusions
Symptomatic and anatomical recurrent POP was associated with this technique of laparoscopic HUSLS. Further research should consider prospective evaluation of these or modified techniques.
Unraveling the role of autophagy and antioxidants in anther and pistil responses to heat stress in rapeseed (Brassica napus L.)
Authors: Mohammadi Valiollah , Rezaeizadeh Ahmad , Mondak Behnam , Rasoulnia Abdolrahman , Domínguez-Figueroa José , Carrillo Laura , Romero-Hernandez Gara , Medina Joaquin 
Published: February 2025

Abstract

Key message
Enhanced antioxidant enzymes activity, particularly superoxide dismutase and catalase, along with autophagy process in reproductive organs, can improve the resilience of rapeseed to heat stress, thereby securing crop yield in the face of global warming.

Abstract
Climate change and global warming have increasingly influenced yield and quality of rapeseed (Brassica napus) almost all across the world. The response of reproductive organs to high-temperature stress was studied in two rapeseed varieties, SAFI5 and DH13 with contrasting levels of heat stress tolerance. Pollen germination, viability, and seed set showed a significant reduction in the heat-sensitive variety (DH13). Superoxide quantification revealed higher accumulation in heat-sensitive variety, leading to decreased seed formation and floret fertility most probably due to declined pollen viability and stigma receptivity. Further microscopic analysis of the anther and pistil demonstrated a significant overlay between the damaged areas and the location of O2
− accumulation. The sensitive variety showed higher O2
− accumulation and a wider damage area than the tolerant one, suggesting that superoxide could incapacitate anther and pistil due to structural injury. Moreover, the activity levels and expression of superoxide dismutase and catalase antioxidant enzymes were significantly higher in the anther and pistil of the tolerant variety. Histochemical analysis also indicated markedly higher autophagosome formation in tolerant variety’s anther and pistil. Consistently, the expression levels of autophagy and ubiquitin-proteasome system (UPS)-related genes including BnATG8d, BnEXO70B, BnATl1 4A, and BnNBR1, as well as ubiquitin-activating enzyme E1, were higher in both reproductive organs of the tolerant variety. Interestingly, the areas of autophagosome formation overlapped with the areas in which higher superoxide accumulation and structural changes happened, suggesting a specific role of autophagy in oxidative stress response.
Splashing correlation for single droplets impacting liquid films under non-isothermal conditions
Authors: Vasconcelos Daniel , Barata Jorge , Silva André 
Published: February 2025

Abstract
The droplet impact phenomenon onto liquid films is predominant in a variety of modern industrial applications, including internal combustion engines and cooling of electronic devices. These are characterised by heat and mass transfer processes, such as evaporation, condensation and boiling. However, studies regarding droplets and liquid films under non-isothermal conditions are scarce in the literature and do not explore temperature-dependent phenomena. Due to this, the main objective of this work is to evaluate the influence of temperature on the splashing occurrence of single droplets impinging onto liquid films under the presence of a heat flux. The crown evolution is evaluated qualitatively to provide insight regarding breakup mechanisms. Water, n-heptane and n-decane are the fluids considered for the current study, as these provide a wide range of thermophysical properties and saturation temperatures. The splashing dynamics are evaluated by varying the droplet impact velocity and dimensionless temperature of the liquid film. Qualitative results show that an increase in the liquid film temperature leads to the transition from spreading to splashing, which is less evident for fuels in comparison with water. For water and n-heptane, the formation of cusps on the crown rim is promoted, which is associated with ligament breakup. For n-decane, the crown rims are relatively homogeneous in terms of shape and size, whereas the atomisation process varies a function of the liquid film temperature. Visually, the secondary droplets exhibit a greater size in comparison with lower temperatures. Transitional regimes display some irregularities, such as splashing suppression/reduction, which require further attention. In terms of splashing correlation, the authors propose to develop a non-splash/splash boundary for both iso- and non-isothermal conditions. Results show that the splashing threshold is dependent on the thermophysical properties and the dimensionless temperature of the liquid film.
Heresy in ENSO teleconnections: atmospheric rivers as disruptors of canonical seasonal precipitation anomalies in the Southwestern US
Authors: Luna-Niño Rosa , Gershunov Alexander , Ralph F. Martin , Weyant Alexander , Guirguis Kristen , DeFlorio Michael J. , Cayan Daniel R. , Williams A. Park 
Published: February 2025

Abstract
In spite of forecasts for anomalous dryness based on the canonical La Niña signal, Water Years 2011, 2017, and 2023 brought copious precipitation to California and the Southwestern United States (SWUS). Although El Niño–Southern Oscillation (ENSO) is the main source of seasonal precipitation predictability for the region, outstanding Atmospheric River (AR) activity produced the unexpected regional wetness in each of these heretical water years (WYs). We define heretical WYs as those that result in precipitation anomalies that oppose those expected based on ENSO canon. We assess the contribution of ARs and other storms to these WYs, finding that heretical La Niña/El Niño WYs were characterized by anomalously robust/deficient AR activity. In California, precipitation accumulation during the heretical La Niña WYs was comparable to or even exceeded that observed during the exceedingly wet WY1998—the textbook canonical El Niño year. Our findings indicate a weaker/stronger relationship between ENSO and AR/non-AR precipitation, primarily driven by storm frequency. Although ARs can disrupt the ENSO-precipitation signal, ENSO still influences the frequency of AR precipitation in the southwestern U.S. desert, the region influenced by ARs that make landfall in Baja California, Mexico. These results highlight the complexity of ENSO's impact on precipitation in the Western US and underscore the need for a nuanced understanding of ENSO’s influence on ARs to improve seasonal precipitation prediction.
Cutaneous wound healing in type 2 diabetes db/db mice was impaired with specific changes in proinflammatory cytokine expression
Authors: Mukai Kanae , Iswara Arya , Nakatani Toshio 
Published: February 2025

Abstract
In db/db mice, cutaneous wound healing was delayed, and excessive wound exudates enlarged the wound. However, the relationship between enlarged wounds and proinflammatory cytokine expression remains unknown. Therefore, we investigated the expression of proinflammatory cytokines Tnf-α and Il-6 in cutaneous wound healing with diabetes. In this study, 12 C57BL/6J mice (wild-type: WT) and 14 db/db mice were subjected to full-thickness wound injuries. Wound healing was assessed until day 14, and wound tissues were harvested on days 7, 9, 11, and 14. The wound areas increased for 4 days, gradually increased until day 9, and stabilized until day 14 in the db/db group, but increased for 3 days, rapidly decreased until day 12, and gradually decreased until day 14 in the WT group. On day 14, the wound area in the db/db group was significantly larger than that in the WT group (p < 0.01). The relative expressions of the Tnf-α and Il-6 in the db/db group were significantly higher than those in the WT group on days 7–14, and on days 11 and 14, respectively (p < 0.05). Our study showed that cutaneous wound healing was delayed with wound expansion and the expression of Tnf-α and Il-6 was high throughout the measurement time points in db/db mice. These abnormal expressions could influence impaired cutaneous wound healing in diabetic mellitus.
Overexpression of the apple SEP1/2-like gene MdMADS8 promotes floral determinacy and enhances fruit flesh tissue and ripening
Authors: Hoong Ling , Ireland Hilary S. , Tomes Sumathi , Gunaseelan Kularajathevan , Ruslan Maryam , McKenzie Catherine , Hallett Ian , David Karine M. , Schaffer Robert J. 
Published: February 2025

Abstract

Main conclusion
The over-expression of the apple SEP1/2 like gene (MADS8) supports its role as a key regulator of fleshy fruit patterning and ripening in pome fruit.

Abstract
Fruit flesh patterning in accessory fruits such as apple and strawberry has been associated with the SEPALLATA (SEP) class of genes. Antisense suppression of multiple SEP homologs greatly reduced fruit fleshy tissue growth and ripening in strawberries and apple, suggesting a co-evolution of fleshy fruit growth and its ability to ripen. In the present study, transgenic apple trees were generated that overexpressed the apple SEP1/2-like gene MADS8 (MADS8ox). These lines produced precocious flowers in the second year of growth, but subsequent flower numbers were not increased. Overexpression MdMADS8 in Arabidopsis promoted flowering and caused curled leaves and a conversion of sepals to petals. In apple, MADS8ox fruit were larger than wild type ‘Royal Gala’ fruit with a higher proportion of flesh tissue compared to core tissue. MADS8ox fruit ripened earlier and faster with higher expression of ripening-related genes such as ACS1 and ACO1. Together, these results add further insights into the role that SEP-like genes have in controlling flowering and fruit patterning and provide further evidence that MdMADS8 is one of the key regulators of fruit flesh development and ripening in apples.
Seasonal dynamics of fine root length in European beech: unveiling unexpected winter peaks and summer declines
Authors: Garthen Aron , Brandt Kirsten , Klisz Marcin , Malyshev Andrey V. , Peters Bo , Weigel Robert , Kreyling Juergen 
Published: February 2025

Abstract
Fine roots play a crucial role in many ecological and biogeochemical processes in temperate forests. Generally, fine root biomass is expected to increase during the growing season, when water and nutrient demands are high, but information on seasonal variability is still scarce. Here, seasonal differences in root length of European beech (Fagus sylvatica L.) were analysed at eight sites within its north-eastern distribution range. Fine roots of mature trees were monitored using minirhizotrons. Scans were taken for three different depths at the beginning of winter, the end of winter and over the summer for two consecutive years, and analysed automatically by an AI-algorithm (RootDetector). An additional experiment was carried out to show that the RootDetector was unaffected by changes in soil moisture. Root-length density was 40% higher at the beginning of winter and 51% higher at the end of winter than in summer. Our results indicate a net root loss during adverse conditions in early summer, but no trend towards deeper root growth over these drier periods. Interestingly, the root loss was compensated afterwards during more favourable conditions in autumn. We could show that fine root length in temperate forests is seasonally more variable and, so far, less predictable than previously assumed. A profound understanding of this seasonal variability is important for modelling terrestrial biogeochemical processes and global carbon fluxes.
Origin of maar clusters at the type locality Eifel (Germany): H2O or CO2?
Authors: Schmincke Hans-Ulrich , Sumita Mari , Chakraborty Sumit , Hansteen Thor H. 
Published: February 2025

Abstract
The closely spaced late glacial Daun and Gillenfeld maar clusters at the maar type locality in western Eifel (Germany) are commonly interpreted to be of phreatomagmatic origin powered by thermohydraulic explosions occurring initially at a depth of 200–300 m below the surface. Our reconnaissance work focusing on the iconoclastic water-filled Pulvermaar (PM) deposits (a funnel-shaped crater 74 m deep and 700 m in diameter surrounded by a tephra ring) and other nearby maars has provided intriguing evidence that CO2-dominated pyroclastic processes at a depth of several kilometers may have been a fundamental factor in generating the volumetrically abundant volcanic pellets (aka subspherical lava lapilli) and the rounded, lava-coated fragments of plutonic and metamorphic rocks (named nodules here) in these deposits. Phreatomagmatic explosions probably contributed to near-surface country rock fragmentation and crater foundering. Supporting lines of evidence for the role of CO2 include the following: (1) the likely high CO2-concentration of the melilite-nephelinite magma; (2) fragments of carbonatite (alkali feldspar intergrown with carbonate) in several maar deposits including the nearby ca. 11 000-year-old Ulmen maar deposits, the youngest volcano in Germany; (3) strongly rounded plutonic and gneiss nodules up to ca. 35 cm in diameter, both interpreted to be of mid-crustal derivation at ca. 20 km depth. The nodules record a complex multiphase dynamic history at depth that commences with an earlier phase of intruded melilite nephelinite into a metamorphic gneissic carapace that was largely crystallized at the time of the eruption. Subsequently, these plutonic as well as the metamorphic rocks were fragmented, followed by thorough milling and rounding of the fragments and eventual lava spray-coating of both types of nodules by a later phase of intruded gas-rich nephelinite magma that was compositionally identical to the older resident intrusion. The prominent role of these processes is reflected by the abundance of volcanic pellets in the lower exposed PM tephra ring deposits and by their dominance in the upper finer-grained well-bedded maar deposits. The pellets are composed of agglutinated smaller nephelinite lapilli and crystal fragments that were possibly derived from collided and fragmented plutonic nodules. The collection of nodules and pellets was most likely transported upward, largely by CO2-flushing and by continuous milling in the transport system, and joined by Devonian rock fragments closer to the surface. In the final stages of ascent, this was probably accompanied by near-surface phreatomagmatic processes including crater-formation.
Short‑term outcomes of minimally invasive endoscopic onlay repair for diastasis recti and ventral hernia repair: a systematic review and meta‑analysis
Authors: Brucchi Francesco , Boni Luigi , Cassinotti Elisa , Baldari Ludovica 
Published: February 2025

Abstract

Background
Endoscopic onlay repair (ENDOR) approach is gaining traction as a promising technique for the treatment of diastasis recti and associated ventral hernia. However, comprehensive evidence regarding its perioperative and short-term outcomes remains scarce. The objective of this meta-analysis is to provide a comprehensive summary of the existing evidence concerning perioperative and short-term postoperative outcomes.

Methods
A systematic literature review was reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). A comprehensive search was conducted in MEDLINE, Embase, and CENTRAL until August 1st, 2024. Articles reporting outcomes of ENDOR in adult population diagnosed with diastasis recti associated or not with primary or incisional ventral hernia were included. Primary outcomes were evaluated based on safety and short-term measures, including intraoperative and short-term postoperative characteristics. A fixed effects model was used for meta-analysis. The methodological quality of the studies was assessed using the Methodological Index for Non-randomized Studies (MINORS) criteria.

Results
A total of 12 studies (480 patients) were identified. Minimally invasive ENDOR resulted in an intraoperative complications and conversion rate of 1.0% [95% CI 0.0–2.0%]. The rate of seroma was 25% [95% CI 12.0–39.0%], the one of surgical site infection was 1% [95% CI 0.0–2.0%] and the rate of hematoma was 2% [95% CI 1.0–3.0%]. After a median follow-up of 16 months (1.8–39), the rate of recurrence was 2% [95% CI 0.0–3.0%].

Conclusions
The minimally invasive ENDOR approach stands out as a safe and effective method for diastasis recti and associated ventral hernia repair in selected patients, exhibiting low rates of intraoperative complications and yielding favorable outcomes.
Prospero registry
Registration number: CRD42024573235
Addition-meet fuzzy relational inequality systems, product-join relational inequality systems and their generalizations
Authors: Turunen Esko 
Published: February 2025

Abstract
Real unit interval valued Addition-min FRI systems are generalized to MV-algebra valued Addition-meet and Product-join fuzzy relational inequality systems, and the latter further to residual lattice valued Product-join relational inequality system. MV-algebra valued Addition-meet FRI systems are further generalized in two ways; on the one hand they are defined on involutive residual lattices and on the other hand as Addition-MV-product systems. It is proved that each such FRI system has a minimal solution or, respectively a maximal solution. The number of such solutions is discussed. Several illustrative examples are given. Through residual lattices and MV-algebras, these systems are linked in a profound way to mathematical fuzzy logic.
Toward better semantic segmentation by retaining spectral information using matched wavelet pooling
Authors: El-Khamy Said , El-Bana Shimaa , Al-Kabbany Ahmad , Elragal Hassan 
Published: February 2025

Abstract
Pooling operations, such as average pooling, strided convolution, and max pooling, have become fundamental components of convolutional neural networks (CNNs) due to their ability to capture local features, expand receptive fields, and reduce computational costs. However, in the context of semantic segmentation, these pooling techniques can lead to the loss of crucial spatial details that are necessary for accurate pixel-level predictions. To tackle this issue, extensive research has focused on refining deep CNN models through architectural adaptations and novel training methods. Recent studies have demonstrated the importance of pooling layers, exemplified by innovations like the introduction of wavelet pooling. In our study, we highlight the value of incorporating our previously proposed matched wavelet pooling (MWP) into CNNs to enhance semantic segmentation pipelines. The core concept of MWP challenges the notion that including all sub-bands generated from wavelet decomposition consistently improves accuracy. Instead, we advocate for selecting specific sub-bands for the pooling process in each image during both training and testing. This approach introduces sub-band selection protocols customized for image-specific pooling, designed specifically for semantic segmentation CNN architectures, with a particular focus on the UNet and SegNet models. Across three widely used datasets, our proposed MWP- based pipeline, featuring the MWP-UNet architecture, consistently outperforms conventional pooling methods. It achieves a significant average improvement in intersection over union (IoU) of over 25% compared to recent literature. Additionally, our MWP-SegNet model outperformed the standard SegNet by 12.5% mIoU, further demonstrating the effectiveness of our matched wavelet pooling approach across different network architectures.
Alveolar socket surface area as a local risk factor for MRONJ development in oncologic patients on polypharmacy
Authors: Gracea Rellyca Sola , Suryani Isti Rahayu , Fontenele Rocharles Cavalcante , Gaêta-Araujo Hugo , Radi Sonya , Elgarba Bahaaeldeen M. , Shujaat Sohaib , Coropciuc Ruxandra , Jacobs Reinhilde 
Published: February 2025

Abstract

Objectives
To determine the impact of alveolar socket surface area and number of root extractions for developing medication-related osteonecrosis of the jaw (MRONJ) in polypharmacy patients following multiple tooth extractions.

Materials and methods
A retrospective sample of 40 patients was recruited, including 20 polypharmacy patients (109 tooth extractions) who developed MRONJ in at least one of the extraction sites, matched with 20 controls (100 tooth extractions). Tooth-specific alveolar socket surface areas were assessed using CBCT scans from the control group to establish reference values for alveolar socket surface areas in polypharmacy patients with MRONJ. Correlations between the number of extracted tooth roots, alveolar socket surface area, and development of MRONJ were analysed within the polypharmacy group.

Results
40% of tooth extractions in polypharmacy patients undergoing multiple extractions resulted in the development of MRONJ, with a higher prevalence observed in the mandible (44%). Among the extracted mandibular tooth roots, half were susceptible to MRONJ, and 45% of the exposed socket surface area was affected. Both jaws showed an increased risk (20%) of MRONJ following molar extraction. A strong positive correlation existed between extraction sites that developed MRONJ and both the number of mandibular tooth roots extracted (r = + 0.861; p < 0.001) and the total exposed alveolar socket surface area (r = + 0.757; p < 0.001). However, no significant correlations were observed in the upper jaw.

Conclusions
This study is the first to demonstrate that both mandibular alveolar socket surface area and number of extracted tooth roots are positively related to extraction sites developing MRONJ in polypharmacy patients undergoing multiple tooth extractions.

Clinical relevance
Identifying high-risk patients and implementing preventive strategies can reduce MRONJ incidence, underscoring the need for careful management of polypharmacy patients, especially those undergoing mandibular tooth extractions.