bluuebunny/crossref_metadata_2025_split huggingface dataset:
Strain-dependent modifiers exacerbate familial leukemia caused by GATA1-deficiency
Authors: Hirano Ikuo , Abe Kanako , Engel James Douglas , Yamamoto Masayuki , Shimizu Ritsuko 
Published: February 2024

AbstractGATA1 plays a critical role in differentiation, proliferation, and apoptosis during erythropoiesis. We developed a Gata1 knock-down allele (Gata1.05) that results in GATA1 expression at 5% of endogenous level. In female mice heterozygous for both the Gata1.05 and wild-type alleles, we observed a predisposition to erythroblastic leukemia three to six months after birth. Since no male Gata1.05 progeny survive gestation, we originally maintained heterozygous females in a mixed genetic background of C57BL/6J and DBA/2 strains. Around 30% of these mice reproducibly develop leukemia, but the other subset did not develop leukemia, even though they harbor a high number of preleukemic erythroblasts. These observations prompted us to hypothesize that there may be potential influence of genetic determinants on the progression of Gata1.05-driven hematopoietic precursors to full-blown leukemia. In an initial examination of Gata1.05/X mice backcrossed into C3H/He, BALB/c, DBA/2, C57BL/6J and 129X1/SvJ strains, we discerned that the backgrounds of C57BL/6J and 129X1/SvJ significantly expedited leukemia onset in Gata1.05/X mice. Conversely, backgrounds of C3H/He, BALB/c and DBA/2 did not substantially modify the effect of the Gata1 mutation. This indicates the existence of genetic modifiers that accentuate Gata1.05 leukemogenesis. Subsequent cohort studies evaluated Gata1.05/X mice within mix backgrounds of BALB/c:129X1/SvJ and BALB/c:C57BL/6J. In these settings, Gata1.05-driven leukemia manifested in autosomal dominant patterns within the 129X1/SvJ background and in autosomal recessive patterns within C57BL/6J background. To the best of our knowledge, this study provides the inaugural evidence of genetic modifiers that can reshape the outcome based on leukemia-associated gene signatures.
Intergenerational transmission of parental child-rearing gender-role attitudes and its influence on gender roles in single-parent families
Authors: Chen I-Jun , Wang Xiaoxiao , Sun Zhiyin , Tang Panlin , Chen Peiyi 
Published: February 2024

Abstract
Background
The development of children’s gender roles in single-parent families is worthy of attention. It may be affected by family members’ gender roles and parental child-rearing gender-role attitudes (PCGA). PCGA will form a consistent or inconsistent intergenerational relationship between parents and children.

Objective
This study examined the intergenerational similarities in gender roles and PCGA. Also, the intergenerational transmission of parental child-rearing gender-role attitudes (ITPCGA) in single-parent families, and the impact of various family factors on children’s gender roles were comprehensively considered.

Method
Participants were 550 single-parent parent-adolescent dyads. The Gender-role Scale and the Parental Child-rearing Gender-role Attitude Scale were used to evaluate participants’ gender-role and PCGA. Chi-square tests and logistic regression analyses were used to examine the intergenerational similarities in gender roles and PCGA, and the influencing family factors of ITPCGA and children’s gender roles.

Results
The intergenerational similarities of gender role types and PCGA types existed. Both parents’ gender roles and family gender pairs affected ITPCGA, father-daughter families and parents’ undifferentiated and sex-typed gender roles significantly predicted undesirable ITPCGA. Family gender pair, parent’s gender roles and ITPCGA types affected children’s gender roles. Undesirable ITPCGA significantly predicted children’s undifferentiated gender roles; father-daughter families and mother-son families, parents’ undifferentiated and sex-typed gender roles significantly predicted children’s sex-typed gender roles, and mother-son families and parents’ reversed gender roles significantly predicted children’s reversed gender role.

Conclusions
This study highlights the effects of single-parent family gender pairs and parents’ gender roles on ITPCGA, which influences the development of children’s gender roles.
Mt. Ebal curse tablet? A refutation of the claims regarding the so called Mt. Ebal curse tablet
Authors: Haughwout Mark S. 
Published: February 2024

Abstract
A refutation of the claims by Scott Stripling et al. regarding the epigraphic analysis and paleographic contents of the folded lead object discovered on Mt. Ebal in 2019 during the wet-sifting of dump piles from a previous archaeological excavation by Adam Zertal. This piece of lead is often referred to as the “Mt. Ebal Curse Tablet”. An article regarding this find, by Stripling et al., titled “You are Cursed by the God YHW:” an early Hebrew inscription from Mt. Ebal”, was published on May 23, 2023, in the Heritage Science journal.
Multi-year assessment of the impact of ship-borne radiosonde observations on polar WRF forecasts in the Arctic
Authors: Choi Yonghan , Kim Joo-Hong , Jun Sang-Yoon , Choi Taejin , Zhang Xiangdong 
Published: February 2024

AbstractTo compensate for the lack of conventional observations over the Arctic Ocean, ship-borne radiosonde observations have been regularly carried out during summer Arctic expeditions and the observed data have been broadcast via the global telecommunication system since 2017. With these data obtained over the data-sparse Arctic Ocean, observing system experiments were carried out using a polar-optimized version of the Weather Research and Forecasting (WRF) model and the WRF Data Assimilation (WRFDA) system to investigate their effects on analyses and forecasts over the Arctic. The results of verification against reanalysis data reveal: (1) DA effects on analyses and forecasts; (2) the reason for the year-to-year variability of DA effects; and (3) the possible role of upper-level potential vorticity in delayed DA effects. The overall assimilation effects of the extra data on the analyses and forecasts over the Arctic are positive. Initially, the DA effects are the most apparent in the temperature variables in the middle/lower troposphere, which spread to the wind variables in the upper troposphere. The effects decrease with time but reappear after approximately 120 h, even in the 240-h forecasts. The effects on forecasts vary depending on the proximity of the radiosonde observation locations to the high synoptic variability. The upper-level potential vorticity is known to play an important role in the development of Arctic cyclones, and it is suggested as a possible explanation for the delayed DA effects after about 120 h.
High-resolution regional gravity field modeling in data-challenging regions for the realization of geopotential-based height systems
Authors: Liu Qing , Schmidt Michael , Sánchez Laura , Moisés Leidy , Cortez Diego 
Published: February 2024

Abstract
Modern height systems are based on the combination of satellite positioning and gravity field models of high resolution. However, in many regions, especially developing or newly industrializing countries, there is no (reliable) regional gravity model at all, due to challenges such as limited data availability, unknown/low data quality, and missing metadata. This paper addresses this issue in a case study of Colombia, where eight decades of historical terrestrial and airborne gravity measurements are available but widely contain systematic errors, outliers, and biases. Correspondingly, processing strategies and structures are proposed and applied to validate and improve the quality of old gravity datasets. A novel method is developed based on spherical radial basis functions (SRBFs) for estimating biases, which are found in different airborne surveys with values exceeding 40 mGal. The validity of this bias estimation method is demonstrated both by a simulation test and by the evaluation of the airborne data in comparison to the SATOP (SAtellite-TOPography) model, which merges the satellite-only global gravity model GOCO06s with the Earth2014 topography model. The terrestrial and airborne data are then combined with a global gravity model (GGM), ultra-high-resolution topography models, as well as altimetry-derived gravity anomalies from DTU21GRA for the offshore areas. The results are presented in terms of height anomalies (QGeoidCOL2023), and they are thoroughly validated using GPS/leveling data both in the absolute and relative manner. The standard deviation in comparison to the GPS/leveling data after applying a correction surface to account for the datum inconsistencies amounts to 15.76 cm, which is 27% smaller compared to the mean standard deviation value given by five recent high-resolution GGMs, and 36% smaller than the one delivered by the latest South American quasi-geoid model QGEOID2021. The relative validation results show that QGeoidCOL2023 performs better, i.e., delivers lower RMS errors than the GGMs and QGEOID2021 in all the baseline length groups. These results indicate the validity and benefits of the developed methods and procedures, which can be used for other data-challenging areas to facilitate the realization of geopotential-based height systems.

Graphical Abstract
Value of diffusion kurtosis MR imaging and conventional diffusion weighed imaging for evaluating response to first-line chemotherapy in unresectable pancreatic cancer
Authors: Zhang Zehua , Zhang Yuqin , Hu Feixiang , Xie Tiansong , Liu Wei , Xiang Huijing , Li Xiangxiang , Chen Lei , Zhou Zhengrong 
Published: February 2024

Abstract
Objective
To investigate the diagnostic value of diffusion kurtosis magnetic resonance imaging (DKI) and conventional diffusion-weighted imaging (DWI) for evaluating the response to first-line chemotherapy in unresectable pancreatic cancer.

Materials and methods
We retrospectively analyzed 21 patients with clinically and pathologically confirmed unresected pancreatic cancer who received palliative chemotherapy. Three-tesla MRI examinations containing DWI sequences with b values of 0, 100, 700, 1400, and 2100 s/mm2 were performed before and after chemotherapy. Parameters included the apparent diffusion coefficient (ADC), mean diffusion coefficient (MD), and mean diffusional kurtosis (MK). The performances of the DWI and DKI parameters in distinguishing the response to chemotherapy were evaluated by the area under the curve (AUC) of the receiver operating characteristic (ROC) curve. Overall survival (OS) was calculated from the date of first treatment to the date of death or the latest follow-up date.

Results
The ADCchange and MDchange were significantly higher in the responding group (PR group) than in the nonresponding group (non-PR group) (ADCchange: 0.21 ± 0.05 vs. 0.11 ± 0.09, P = 0.02; MDchange: 0.37 ± 0.24 vs. 0.10 ± 0.12, P = 0.002). No statistical significance was shown when comparing ADCpre, ADCpost, MKpre, MKpost, MKchange, MDpre, and MDpost between the PR and non-PR groups. The ROC curve analysis indicated that MDchange (AUC = 0.898, cutoff value = 0.7143) performed better than ADCchange (AUC = 0.806, cutoff value = 0.1369) in predicting the response to chemotherapy.

Conclusion
The ADCchange and MDchange demonstrated strong potential for evaluating the response to chemotherapy in unresectable pancreatic cancer. The MDchange showed higher specificity in the classification of PR and non-PR than the ADCchange. Other parameters, including ADCpre, ADCpost, MKpre, MKpost, MKchange, MDpre, and MDpost, are not suitable for response evaluation. The combined model SUMchange demonstrated superior performance compared to the individual DWI and DKI models. Further experiments are needed to evaluate the potential of DWI and DKI parameters in predicting the prognosis of patients with unresectable pancreatic cancer.
Quantitative risk assessment for static and mobile road users: methodology and application at A82 Glen Coe, Scotland
Authors: Winter M. G. , Waaser T. , Fiddes G. 
Published: February 2024

Abstract
Background
In August 2004 a series of debris flows caused significant disruption to the Scottish (strategic) Trunk Road Network. The subsequent Scottish Road Network Landslides Study identified a number of sites considered to be at highest risk. Some of these sites have been the subject of formal quantitative assessment of the risk from debris flow to mobile road users in vehicles. The A82 in Glen Coe has the added complication that two car parks have developed on debris fans exposing significant numbers of people to the risk while, they are essentially static and largely outside their vehicles.

Methodology
The risk to road users is determined using a previously developed probabilistic methodology for mobile road users (mobile elements at risk) and a new and related methodology developed for static road users (static elements at risk) is described and applied. Within the latter, an entirely new metric of Annual Average Daily Visits is used to allow the temporal component of the probability of a landslide impacting a person to be determined given the occurrence of an event.

Results
While Personal Individual Risk is at an acceptable level, including for frequent users, the risk presented to society as a whole presents a rather different picture; this is largely due to the number of visitors. The results assess the overall, societal risk for mobile elements at risk as As Low As reasonably Practicable, being at a similar level to other sites, albeit with a higher risk associated with higher numbers of fatalities. The results for the static elements at risk on the other hand suggest that the risks are classified as Unacceptable for higher numbers of fatalities. The assessment of the total societal risk, for mobile and static elements at risk, at the A82 Glen Coe suggests As Low As Reasonably Practicable for low numbers of fatalities but classify as Unacceptable for higher numbers of fatalities (around 20 to 250).
Morphometric analysis of posterior cranial fossa and foramen magnum and it’s clinical implications in craniovertebral junction malformations: a computed tomography based institutional study in a tertiary care hospital of northern part of India
Authors: Yadav Vikrant , Prasad Ravi Shankar , Sahu Anurag , Mishra Manish Kumar , Pradhan Ravi Shekhar 
Published: February 2024

Abstract
Background
The posterior cranial fossa (PCF) and the foramen magnum (FM) are the critical anatomical components of the craniovertebral junction region, which comprise and transmit numerous vital neurovascular structures. So, a fundamental knowledge of the basic radiological anatomy of PCF and FM is of paramount importance in the evaluation of associated pathologies and approaching these areas surgically. The aim of this study is to describe different linear and angular craniometric parameters of PCF, FM and surrounding territory based on reconstructed computed tomography (CT) images.

Material and methods
This study was conducted in our tertiary care hospital in northern India from the period of January 2023 to June 2023 on 120 patients, and CT screening was done for the head and spine region following a history of head injury.

Results
In this study, 120 patients were included, of whom 50.83% (n = 61) were females and 49.17% (n = 59) were males. Age ranged from 18 to 70 years with mean age of 43.5 ± 14.08 years. The mean values for linear craniometric parameters of PCF were statistically nonsignificant for different age groups. Statistically significant differences were found for twinning line (TL) (p < 0.0001), McRae’s line (< 0.0001), clivus length (< p < 0.0001), internal occipital protuberence -opisthion line (p = 0.01), Klaus’ index (p < 0.0001), height of posterior fossa (h) (p < 0.0001), h/TL (p = 0.028), when these values were compared for the genders. The measurements of FM transverse diameter, anteroposterior diameter and area were 27.12 ± 1.42 mm (range 23.6–30.1 mm), 30.99 ± 2.23 mm (range 27.6–35.8 mm) and 691.32 ± 30.35 mm2 (range 632.7–777.7 mm2). The values of clivus canal angle (p = 0.038) and clivoodontoid angle (p = 0.012) were statistically significant when compared for different age groups. The values of Boogard’s angle (p = 0.021) and tentorial slope (p = 0.031) were statistically significant when these were compared for the genders.

Conclusions
This study described almost all the linear and angular craniometric parameters used in the morphometric analysis of PCF and FM. The findings of this study provide valuable data regarding linear and angular craniometric parameters of PCF and FM which can redefine reference values.
Enhanced fault detection in polymer electrolyte fuel cells via integral analysis and machine learning
Authors: Melo Ester , Barzola-Monteses Julio , Noriega Holguer H. , Espinoza-Andaluz Mayken 
Published: February 2024

AbstractThe growing energy demand and population raising require alternative, clean, and sustainable energy systems. During the last few years, hydrogen energy has proven to be a crucial factor under the current conditions. Although the energy conversion process in polymer electrolyte fuel cells (PEFCs) is clean and noiseless since the only by-products are heat and water, the inside phenomena are not simple. As a result, correct monitoring of the health situation of the device is required to perform efficiently. This paper aims to explore and evaluate the machine learning (ML) and deep learning (DL) models for predicting classification fault detection in PEFCs. It represents a support for decision-making by the fuel cell operator or user. Seven ML and DL model classifiers are considered. A database comprising 182,156 records and 20 variables arising from the fuel cell's energy conversion process and operating conditions is considered. This dataset is unbalanced; therefore, techniques to balance are applied and analyzed in the training and testing of several models. The results showed that the logistic regression (LR), k-nearest neighbor (KNN), decision tree (DT), random forest (RF), and Naive Bayes (NB) models present similar and optimal trends in terms of performance indicators and computational cost; unlike support vector machine (SMV) and multi-layer perceptron (MLP) whose performance is affected when the data is balanced and even presents a higher computational cost. Therefore, it is a novel approach for fault detection analysis in PEFC that combines the interpretability of different ML and DL algorithms while addressing data imbalance, so common in the real world, using resampling techniques. This methodology provides clear information for the model decision-making process, improving confidence and facilitating further optimization; in contrast to traditional physics-based models, paving the way for data-driven control strategies.
Intra-pericardial thrombin injection in iatrogenic cardiac tamponade: a case report
Authors: Morales Juana Perez , Spaccavento Ana , Ordoñez Santiago , Baro Rocío , Conde Diego , Costabel Juan Pablo 
Published: February 2024

Abstract
Background
Nowadays, percutaneous procedures are expanding in use, and this comes with complications associated with the procedure itself. Cardiac tamponade is rare but may be life threatening since it can involve hemodynamic instability. It is known that after pleural effusion during a percutaneous procedure, pericardiocentesis should be used as drainage of the cavity. However, that does not achieve hemostasis in some cases, and in those patients who are hemodynamically unstable, a sealing agent to promote hemostasis might be useful, like thrombin.

Case presentation
We present a case report of 89-year-old patient with history of melanoma undergoing treatment with pembrolizumab, who attended the emergency department referring chest pain (intensity 5/10) and palpitations that have lasted hours. He had TnTUs 554/566 ng/L and an echocardiogram that showed dilated right chambers, hypertrophy and global hypokinesia of the left ventricle, increased filling pressures of the left ventricle and pulmonary hypertension. Myocarditis associated with pembrolizumab was suspected, so high dose steroids were initiated and endomyocardial biopsy was conducted, resulting in iatrogenic cardiac tamponade. To determine the etiology of the suspected myocarditis, an endomyocardial biopsy was performed. Unfortunately, an intraprocedural complication arose: pleural effusion resulting in iatrogenic cardiac tamponade, leading to hemodynamic instability. It required immediate pericardial drainage via subxiphoid puncture, obtaining a 550 mL hematic debit. Clinical manifestations raised suspicion of tamponade, prompting a bedside echocardiogram for a definitive diagnosis. Despite these efforts, the patient remained hemodynamically unstable, and due to the elevated surgical risk, intrapericardial thrombin was employed to achieve successful hemostasis.

Conclusions
Cardiac tamponade is a life-threatening condition that can sometimes be induced iatrogenically, resulting from percutaneous interventions. Despite limited evidence regarding this therapeutic strategy, in patients experiencing iatrogenic cardiac tamponade with hemodynamic instability and high surgical risk, the administration of intra-pericardial thrombin could be contemplated.
Poorly differentiated papillary thyroid carcinoma in a 5-year-old girl: a case report
Authors: Mohsen Mohanned , Hamdy Omar , Ramadan Ahmad , Awny Shadi , Zalata Khaled , Ezat Mohamed 
Published: February 2024

Abstract
Background
The incidence of thyroid cancer has been increasing among the population less than 20 years of age, especially during the second decade of life. Differentiated papillary thyroid cancer is the most common pathology in children. It usually presents with thyroid nodules with or without cervical lymphadenopathy. Thyroid nodules carry a considerable risk of malignancy in children.

Case presentation
We herein report a 5-year-old girl with poorly differentiated papillary thyroid cancer which is an extremely rare finding at this age. The patient underwent right thyroid lobectomy followed by left hemi thyroidectomy and right central and lateral neck dissection. Pathologic examination revealed a poorly differentiated papillary thyroid carcinoma with nodal deposits.

Conclusion
It is essential to raise awareness of proper evaluation and management of thyroid nodules at such an age.
Impact of financial distress on the dividend policy of banks in India: evidence using panel data
Authors: Rawal Aashi , Gopalkrishnan Santosh 
Published: February 2024

AbstractThe study primarily aims to examine the impact of financial distress on the dividend distribution policy of banks operating in India. Panel data analysis was performed using a static model to investigate the impact of distress on the bank’s dividend policy. The Z-score developed by Altman measures a bank’s financial distress (a high Z-score indicates the absence of financial distress). Data from 31 out of 34 banks operating in India between 2016 and 2020 has been used. The debt/equity ratio is used as the moderator. The sales log is used as the control variable. A linear connection exists between financial distress and dividends. Furthermore, debt/equity ratio significantly moderates the association of financial distress with dividend policy. The findings contribute to formulating a long-term dividend policy by drawing attention to the distressing situation in the banking sector, focusing on ensuring the banks’ financial viability. Thereby, the findings are novel and hold significant worth in improving the current understanding of the subject.