bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phenotypic characterization of predictors for development and progression of geographic atrophy using optical coherence tomography.
Authors: Fragiotta Serena , Dysli Chantal , Parravano Mariacristina , Sacconi Riccardo , Fantaguzzi Federico , Servillo Andrea , Severo Alice Antonella , Tombolini Beatrice , Costanzo Eliana , De Geronimo Daniele , Capuano Vittorio , Souied Eric , Bandello Francesco , Querques Giuseppe 
Published: March 2024

Purpose:
To evaluate the impact of optical coherence tomography (OCT) phenotypes preceding atrophy related to age-related macular degeneration (AMD) on the progression of atrophic lesions.

Methods:
In this observational retrospective cohort study, a total of 70 eyes of 60 consecutive patients with intermediate AMD with a minimum follow-up of 24 months were included. The atrophy was quantified using fundus autofluorescence, also considering the directionality of atrophy as centrifugal and centripetal progression rates.
Main outcome measures were geographic atrophy (GA) progression rate (mm2/year) and square root-transformation GA (mm2/year).

Results:
The best-fit model for GA (OR: 1.81, p<0.001) and square root-transformation GA (OR: 1.36, p<0.001) areas revealed that the main baseline predictor was the presence of an RPE-basal lamina-(BL)-Bruch’s membrane (BrM) splitting. Large drusen at baseline appeared protective for the GA area lesion expansion over time (OR: 0.52, p<0.001) when considered with other confounders.

Conclusion:
A thin RPE-BL-BrM splitting without evidence of neovascularization on OCT angiography likely represents an OCT signature for late basal laminar deposits. Identifying this phenotype can help identify individuals with a higher risk of rapid progression and atrophy expansion.
Comparison of compartmental analytical BOLD fMRI models against Monte Carlo simulations performed over cortical micro-angiograms
Authors: Charest Jordan , Walsh Mathieu , Genois Élie , Sévigny Emmanuelle , Schwarz Pierre-Olivier , Gagnon Louis , Desjardins Michèle 
Published: March 2024

AbstractBOLD fMRI arises from a physiological and physical cascade of events taking place at the level of the cortical microvasculature which constitutes a medium with complex geometry. Several analytical models of the BOLD contrast have been developed but these have not been compared directly against detailed bottom-up modeling methods. Using a 3D modeling method based on experimentally measured images of mice microvasculature and Monte Carlo simulations, we quantified the accuracy of two analytical models to predict the amplitude of the BOLD response from 1.5T to 7T, for different TE and for both gradient echo and spin echo acquisition protocols. We also showed that accounting for the tridimensional structure of the microvasculature results in more accurate prediction of the BOLD amplitude, even if the values for SO2were averaged across individual vascular compartments. A secondary finding is that modeling the venous compartment as two individual compartments results in more accurate prediction of the BOLD amplitude compared to standard homogenous venous modeling, arising from the bimodal distribution of venous SO2across the microvasculature in our data.
Optimal channel selection considering price competition and information sharing under demand uncertainty
Authors: Chen Nan , Cai Jianfeng , Kannan Devika , Govindan Kannan 
Published: March 2024

PurposeThe rapid development of the Internet has led to an increasingly significant role for E-commerce business. This study examines how the green supply chain (GSC) operates on the E-commerce online channel (resell mode and agency mode) and the traditional offline channel with information sharing under demand uncertainty.Design/methodology/approachThis study builds a multistage game model that considers the manufacturer selling green products through different channels. On the traditional offline channel, the competing retailers decide whether to share demand signals. Regarding the resale mode of E-commerce online channel, just E-tailer 1 determines whether to share information and decides the retail price. In the agency mode, the manufacturer decides the retail price directly, and E-tailer 2 sets the platform rate.FindingsThis study reveals that information accuracy is conducive to information value and profits on both channels. Interestingly, the platform fee rate in agency mode will inhibit the effect of a positive demand signal. Information sharing will cause double marginal effects, and price competition behavior will mitigate such effects. Additionally, when the platform fee rate is low, the manufacturer will select the E-commerce online channel for operation, but the retailers' profit is the highest in the traditional channel.Originality/valueThis research explores the interplay between different channel structures and information sharing in a GSC, considering price competition and demand uncertainty. Besides, we also considered what behaviors and factors will amplify or transfer the effect of double marginalization.
Practice Briefing Market indications and property returns in the UK
Authors: Papadakos Peter 
Published: March 2024

PurposeThe intent of this Practice Briefing is to provide clarity on drivers of property pricing in a changing economic environment. The principal basis of this analysis is to investigate how properties have been priced relative to interest rates over the long haul. Such an insight may help investors navigate the world of property investment in a post zero interest-rate policy (ZIRP) world.Design/methodology/approachThis practice briefing is an overview of the role of economic drivers in pricing property in different economic eras pre- and post-ZIRP. It looks at returns over time relative to risk criteria and growth.FindingsThis briefing is a review of property pricing and its relationship to economic drivers and discusses the concept of return premiums as a market indicator to spot under/over-priced property assets in the market.Practical implicationsThis briefing considers the implications of identifying salient and pertinent market indicators over time as bellweathers for property pricing. Good property investment is grounded in understanding when assets are under and overpriced relative to investors’ expectations of growth and returns going forward. An understanding of markets and the current indicators thereof can provide investors with insights into those criteria.Originality/valueThis provides guidance on how to interpret markets and get an understanding of property pricing over time.
Reforming the Established Church: History and Proposals
Authors: Torrance David 
Published: March 2024

AbstractWhile the term ‘establishment’ is ambiguous, it generally refers to a formal relationship between a church and the state in which it operates. This can range from parliamentary representation (as with the Church of England) to mere observance by the monarch (as at the Church of Scotland's annual General Assembly). Since the 1960s there have been proposals regarding Crown appointments and the number and status of the Lords Spiritual. There exists no major push for full disestablishment of the Church of England, but a bill is currently before Parliament.
Lip, oral and oropharyngeal cancer incidence among Aboriginal and Torres Strait Islander Peoples: First report from Australian population‐based cancer registry, 1999–2018
Authors: Sethi S , Ju X , Logan R , Hedges J , Garvey G , Jamieson L 
Published: March 2024

ABSTRACTBackgroundThe Australian Burden of Disease Study has shown that cancer is the single most important entity responsible for the greatest cause of health burden in Australia. Unfortunately, Aboriginal and Torres Strait Islander peoples experience a greater burden of this disease, with cancer of the lung, breast, bowel and prostrate being the most common. Lip, oral cavity and pharyngeal cancer incidence is rapidly rising globally and is now the sixth most common cancer in Australia. This paper aims to summarize, for the first time, the incidence and prevalence trends of lip, oral cavity and pharyngeal cancers in Aboriginal and Torres Strait Islander Australians.MethodsData were obtained from the Australian Cancer Database (ACD), which is compiled at the Australian Institute of Health and Welfare (AIHW) from 1999 to 2018 to estimate the incidence and prevalence of certain head and neck cancers (ICD‐10 codes C00–C10, C14). The other variables requested were age groups and sex.ResultsResults were stratified by ICD‐10 code, sex and age group at diagnosis and time period (i.e. grouped years of diagnosis). The total incidence of lip, oral cavity and pharyngeal cancers increased by 1.3 times from 1999 to 2008 (107/100 000) to 2009–2018 (135/100 000). The overall 5‐year prevalence of lip, oral cavity and pharyngeal cancers was 0.17% (0.24% for men and 0.09% for women).ConclusionsThe significantly increased incidence of lip, oral cavity and pharyngeal cancers in Aboriginal and Torres Strait Islander peoples in Australia is concerning and should be explored. A targeted, comprehensive and culturally safe model of care for Aboriginal and Torres Strait Islander peoples with lip, oral cavity and pharyngeal cancers is imperative.
Sex differences on constitutive long non‐coding RNA expression: Modulatory effect of estradiol and testosterone in muscle cells
Authors: López‐Royo Tresa , Moreno‐Martínez Laura , Moreno‐García Leticia , Calvo Ana Cristina , Manzano Raquel , Osta Rosario 
Published: March 2024

AbstractIntroductionDespite the growing awareness of sexual dimorphism between males and females under pathological and physiological conditions, sex bias in biomedical research in animal models and patients is still present nowadays. The main objective of this work was to investigate sex differences in constitutive long non‐coding RNA expression in spinal cord and skeletal muscle from wild‐type mice.Materials and MethodsTo assess the influence of gender on long non‐coding RNAs, we extracted RNA from tissues of male and female mice and analyzed the expression on nine long non‐coding RNAs, selected for being among the most commonly studied or exerting an important role in muscle, at 50, 60, and 120 days of age.Results and DiscussionWe observed age‐ and tissue‐dependent significant sex differences, being more prominent in skeletal muscle. We also studied the effect of sex steroid hormones on long non‐coding RNA expression in vitro, noticing a modulation of long non‐coding RNA levels upon estradiol and dihydrotestosterone treatment in muscle.ConclusionsTaken together, results obtained evidenced sex differences on constitutive long non‐coding RNA expression and suggested an influence of steroid hormones complementary to other possible factors. These findings emphasize the importance of including both sexes in experimental design to minimize any potential sex bias.
Testicular niche repair after gonadotoxic treatments: Current knowledge and future directions
Authors: Mohammadi Amirhossein , Bashiri Zahra , Rafiei Sara , Asgari Hamidreza , Shabani Ronak , Hosseini SeyedJamal , Koruji Morteza 
Published: March 2024

AbstractThe testicular niche, which includes the germ cells, somatic cells, and extracellular matrix, plays a crucial role in maintaining the proper functions of the testis. Gonadotoxic treatments, such as chemotherapy and radiation therapy, have significantly improved the survival rates of cancer patients but have also been shown to have adverse effects on the testicular microenvironment. Therefore, repairing the testicular niche after gonadotoxic treatments is essential to restore its function. In recent years, several approaches, such as stem cell transplantation, gene therapy, growth factor therapy, and pharmacological interventions have been proposed as potential therapeutic strategies to repair the testicular niche. This comprehensive review aims to provide an overview of the current understanding of testis damage and repair mechanisms. We will cover a range of topics, including the mechanism of gonadotoxic action, repair mechanisms, and treatment approaches. Overall, this review highlights the importance of repairing the testicular niche after gonadotoxic treatments and identifies potential avenues for future research to improve the outcomes for cancer survivors.
Precursors to infant sensorimotor synchronization to speech and non‐speech rhythms: A longitudinal study
Authors: Rocha Sinead , Attaheri Adam , Ní Choisdealbha Áine , Brusini Perrine , Mead Natasha , Olawole‐Scott Helen , Boutris Panagiotis , Gibbon Samuel , Williams Isabel , Grey Christina , Alfaro e Oliveira Maria , Brough Carmel , Flanagan Sheila , Ahmed Henna , Macrae Emma , Goswami Usha 
Published: March 2024

AbstractImpaired sensorimotor synchronization (SMS) to acoustic rhythm may be a marker of atypical language development. Here, Motion Capture was used to assess gross motor rhythmic movement at six time points between 5‐ and 11 months of age. Infants were recorded drumming to acoustic stimuli of varying linguistic and temporal complexity: drumbeats, repeated syllables and nursery rhymes. Here we show, for the first time, developmental change in infants’ movement timing in response to auditory stimuli over the first year of life. Longitudinal analyses revealed that whilst infants could not yet reliably synchronize their movement to auditory rhythms, infant spontaneous motor tempo became faster with age, and by 11 months, a subset of infants decelerate from their spontaneous motor tempo, which better accords with the incoming tempo. Further, infants became more regular drummers with age, with marked decreases in the variability of spontaneous motor tempo and variability in response to drumbeats. This latter effect was subdued in response to linguistic stimuli. The current work lays the foundation for using individual differences in precursors of SMS in infancy to predict later language outcomes.Research Highlight
We present the first longitudinal investigation of infant rhythmic movement over the first year of life
Whilst infants generally move more quickly and with higher regularity over their first year, by 11 months infants begin to counter this pattern when hearing slower infant‐directed song
Infant movement is more variable to speech than non‐speech stimuli
In the context of the larger Cambridge UK BabyRhythm Project, we lay the foundation for rhythmic movement in infancy to predict later language outcomes
Global patterns of allochthony in stream–riparian meta‐ecosystems
Authors: Allen Daniel C. , Larson James , Murphy Christina A. , Garcia Erica A. , Anderson Kurt E. , Busch Michelle H. , Argerich Alba , Belskis Alice M. , Higgins Kierstyn T. , Penaluna Brooke E. , Saenz Veronica , Jones Jay , Whiles Matt R. 
Published: March 2024

AbstractEcosystems that are coupled by reciprocal flows of energy and nutrient subsidies can be viewed as a single “meta‐ecosystem.” Despite these connections, the reciprocal flow of subsidies is greatly asymmetrical and seasonally pulsed. Here, we synthesize existing literature on stream–riparian meta‐ecosystems to quantify global patterns of the amount of subsidy consumption by organisms, known as “allochthony.” These resource flows are important since they can comprise a large portion of consumer diets, but can be disrupted by human modification of streams and riparian zones. Despite asymmetrical subsidy flows, we found stream and riparian consumer allochthony to be equivalent. Although both fish and stream invertebrates rely on seasonally pulsed allochthonous resources, we find allochthony varies seasonally only for fish, being nearly three times greater during the summer and fall than during the winter and spring. We also find that consumer allochthony varies with feeding traits for aquatic invertebrates, fish, and terrestrial arthropods, but not for terrestrial vertebrates. Finally, we find that allochthony varies by climate for aquatic invertebrates, being nearly twice as great in arid climates than in tropical climates, but not for fish. These findings are critical to understanding the consequences of global change, as ecosystem connections are being increasingly disrupted.
Frequency of ischaemic stroke and intracranial haemorrhage in patients with reversible cerebral vasoconstriction syndrome (RCVS) and posterior reversible encephalopathy syndrome (PRES) – A systematic review
Authors: Kaufmann Jana , Buecke Philipp , Meinel Thomas , Beyeler Morin , Scutelnic Adrian , Kaesmacher Johannes , Mujanović Adnan , Dobrocky Thomas , Arsany Hakim , Peters Nils , Z'Graggen Werner , Jung Simon , Seiffge David 
Published: March 2024

AbstractBackgroundPosterior reversible encephalopathy syndrome (PRES) and reversible cerebral vasoconstriction syndrome (RCVS) may cause ischaemic stroke and intracranial haemorrhage. The aim of our study was to assess the frequency of the afore‐mentioned outcomes.MethodsWe performed a PROSPERO‐registered (CRD42022355704) systematic review and meta‐analysis accessing PubMed until 7 November 2022. The inclusion criteria were: (1) original publication, (2) adult patients (≥18 years), (3) enrolling patients with PRES and/or RCVS, (4) English language and (5) outcome information. Outcomes were frequency of (1) ischaemic stroke and (2) intracranial haemorrhage, divided into subarachnoid haemorrhage (SAH) and intraparenchymal haemorrhage (IPH). The Cochrane Risk of Bias tool was used.ResultsWe identified 848 studies and included 48 relevant studies after reviewing titles, abstracts and full text. We found 11 studies on RCVS (unselected patients), reporting on 2746 patients. Among the patients analysed, 15.9% (95% CI 9.6%–23.4%) had ischaemic stroke and 22.1% (95% CI 10%–39.6%) had intracranial haemorrhage. A further 20.3% (95% CI 11.2%–31.2%) had SAH and 6.7% (95% CI 3.6%–10.7%) had IPH. Furthermore, we found 28 studies on PRES (unselected patients), reporting on 1385 patients. Among the patients analysed, 11.2% (95% CI 7.9%–15%) had ischaemic stroke and 16.1% (95% CI 12.3%–20.3%) had intracranial haemorrhage. Further, 7% (95% CI 4.7%–9.9%) had SAH and 9.7% (95% CI 5.4%–15%) had IPH.ConclusionsIntracranial haemorrhage and ischaemic stroke are common outcomes in PRES and RCVS. The frequency reported in the individual studies varied considerably.
Moving gender across, between and beyond the binaries: In conversation with Shona Bettany, Olimpia Burchiellaro and Rohan Venkatraman
Authors: Cheded Mohammed , Hutton Martina , Steinfield Laurel , Bettany Shona , Burchiellaro Olimpia , Venkatraman Rohan 
Published: March 2024

AbstractThis panel discussion explores why marketing and consumer behavior has struggled to move beyond the binary, the importance of disrupting the conventional binaries to recognize gender/sex/ual diversity, and the challenges in so doing. It raises to the fore concerns about institutional pressures, sanitization of work, academic positionalities, everyday encounters of discrimination against gender/sex/ual diversity, and the emancipatory but oppressive dynamics of categories. Yet the panelists also reflect on ways to challenge binaristic thinking. Just being in the academy and doing (small but) meaningful acts of institutional activism can produce ripple effects and open pathways for a better articulation of lived experiences and realities.
Divide and conquer: Spatial and temporal resource partitioning structures benthic cyanobacterial mats
Authors: Powell Maya E. , McCoy Sophie J. 
Published: March 2024

AbstractBenthic cyanobacterial mats are increasing in abundance worldwide with the potential to degrade ecosystem structure and function. Understanding mat community dynamics is thus critical for predicting mat growth and proliferation and for mitigating any associated negative effects. Carbon, nitrogen, and sulfur cycling are the predominant forms of nutrient cycling discussed within the literature, while metabolic cooperation and viral interactions are understudied. Although many forms of nutrient cycling in mats have been assessed, the links between niche dynamics, microbial interactions, and nutrient cycling are not well described. Here, we present an updated review on how nutrient cycling and microbial community interactions in mats are structured by resource partitioning via spatial and temporal heterogeneity and succession. We assess community interactions and nutrient cycling at both intramat and metacommunity scales. Additionally, we present ideas and recommendations for research in this area, highlighting top‐down control, boundary layers, and metabolic cooperation as important future directions.
Five pathways into one profession: Fifty years of debate on differentiated nursing practice
Authors: Schalkwijk Hugo , Felder Martijn , Lalleman Pieterbas , Parry Manon S. , Schoonhoven Lisette , Wallenburg Iris 
Published: March 2024

AbstractThe persistence of multiple educational pathways into the nursing profession continues to occupy scholars internationally. In the Netherlands, various groups within the Dutch healthcare sector have tried to differentiate nursing practice on the basis of educational backgrounds for over 50 years. Proponents argue that such reforms are needed to retain bachelor‐trained nurses, improve quality of care and strengthen nurses' position in the sector. Opponents have actively resisted reforms because they would mainly benefit bachelor‐trained nurses and neglect practical experience and technical skills. This historical case study aims to provide insight in this apparent stalemate. Our analysis of this debate is informed by literature on institutional work and current debates within the historiography of nursing. This study contributes to a better understanding of this contemporary debate by examining a broader timeframe than is usually studied, and by highlighting nurses' roles in complex processes of change. We argue that, rather than being stuck in their professional development, different groups of nurses have forged their own path forward in their professional development, albeit via different strategies.
When “more for others, less for self” leads to co‐benefits: A tri‐MRI dyad‐hyperscanning study
Authors: Wang Le‐Si , Chang Yi‐Cing , Liou Shyhnan , Weng Ming‐Hung , Chen Der‐Yow , Kung Chun‐Chia 
Published: March 2024

AbstractUnselfishness is admired, especially when collaborations between groups of various scales are urgently needed. However, its neural mechanisms remain elusive. In a tri‐MRI dyad‐hyperscanning experiment involving 26 groups, each containing 4 participants as two rotating pairs in a coordination game, we sought to achieve reciprocity, or “winning in turn by the two interacting players,” as the precursor to unselfishness. Due to its critical role in social processing, the right temporal–parietal junction (rTPJ) was the seed for both time domain (connectivity) and frequency domain (i.e., coherence) analyses. For the former, negative connectivity between the rTPJ and the mentalizing network areas (e.g., the right inferior parietal lobule, rIPL) was identified, and such connectivity was further negatively correlated with the individual's final gain, supporting our task design that “rewarded” the reciprocal participants. For the latter, cerebral coherences of the rTPJs emerged between the interacting pairs (i.e., within‐group interacting pairs), and the coupling between the rTPJ and the right superior temporal gyrus (rSTG) between the players who were not interacting with each other (i.e., within‐group noninteracting pairs). These coherences reinforce the hypotheses that the rTPJ–rTPJ coupling tracks the collaboration processes and the rTPJ–rSTG coupling for the emergence of decontextualized shared meaning. Our results underpin two social roles (inferring others’ behavior and interpreting social outcomes) subserved by the rTPJ‐related network and highlight its interaction with other‐self/other‐concerning brain areas in reaching co‐benefits among unselfish players.