bluuebunny/crossref_metadata_2025_split huggingface dataset:
Case report: Targeted treatment strategies for Erdheim-Chester disease
Authors: Gulyás Anita , Pinczés László Imre , Mátyus János , Végh Edit , Bedekovics Judit , Tóth Judit , Barna Sándor , Hunya Zsolt , Szabó Imre Lőrinc , Gazdag Annamária , Illés Árpád , Magyari Ferenc 
Published: March 2024

IntroductionErdheim-Chester disease (ECD) is a rare disease that belongs to the group of Dendritic and histiocytic neoplasms. Only 2000 cases have been reported worldwide. It can present with a wide range of symptoms, making a differential diagnosis especially difficult. The primary and most important diagnostic tool is a biopsy of the affected organ/tissue. Nowadays the analysis of different mutations affecting the BRAF and MAPK pathways makes it possible to use targeted treatments, such as vemurafenib, dabrafenib, or cobimetinib.ObjectiveOur aim is to present the results of three male patients treated in our hematology department.ResultsOur BRAF mutation-positive patient presented with retroperitoneal tissue proliferation and diabetes insipidus. The initial therapy of choice was dabrafenib. After 3 months of treatment, 18F-fluoro-deoxyglucose positron emission tomography (FDG-PET)/computed tomography (CT) scans showed regression, and after 2 years of treatment, no disease activity was detected. In our second patient, a recurrent febrile state (not explained by other reasons) and diabetes insipidus suggested the diagnosis. A femoral bone biopsy confirmed BRAF-negative ECD. The first-line therapy was interferon-alpha. After 3 months of treatment, no response was observed on 18FDG-PET/CT, and treatment with cobimetinib was started. The control 18FDG-PET/CT imaging was negative. Our third patient was evaluated for dyspnea, and a CT scan showed fibrosis with hilar lymphadenomegaly. A lung biopsy confirmed BRAF-negative ECD. We started treatment with interferon-alpha, but unfortunately, no improvement was observed. Second-line treatment with cobimetinib resulted in a partial metabolic response (PMR) according to control 18FDG-PET/CT.ConclusionsOur results demonstrate that an appropriately chosen treatment can lead to a good therapeutic response, but dose reduction may be necessary due to side effects. With advanced targeted therapeutic treatment options, survival and quality of life are significantly improved.
Tislelizumab induced dual organs dysfunction in a patient with advanced esophageal squamous cell carcinoma: a case report
Authors: Yang Bo , Gou Wei , Lan Naiying , Shao Qing , Hu Weifeng , Xue Cheng , Liu Nanmei 
Published: March 2024

BackgroundTislelizumab, a humanized IgG4 anti-PD-1 monoclonal antibody has been approved in China and Europe. According to the published clinical research, tislelizumab shows satisfactory safety profile. No severe hepatotoxicity or acute kidney injury were reported.Case presentationWe presented a case study of a 74-year-old man who developed acute kidney injury (grade 3) and acute liver injury (grade 4) after being administered tislelizumab for the treatment of esophageal squamous cell carcinoma. We reviewed the patient’s history, physical examination, and laboratory findings and provided comprehensive differentials of the possible causes of the toxicities. Immune Checkpoint Inhibitors (ICI) hepatotoxicity and nephrotoxicity were confirmed clinically. We also discussed the management of toxicities associated with ICIs and the need for a multidisciplinary approach to care.ConclusionsThe case highlights the importance of close monitoring and prompt management of toxicities associated with ICIs and the need for further research to better understand the risk factors for these toxicities and to identify effective treatments for them.
Efficacy of botanical lozenges in the treatment of chronic pharyngitis: a randomized controlled trial
Authors: Wu Yi , Zhang Feng , Kuang Dan , Li Dan , Yan Jiai , Yang Ju , Wang Qinyue , Wang Yingyu , Sun Jing , Liu Yiran , Xia Yanping , Cao Hong 
Published: March 2024

Background: In clinical practice, antibiotics and/or inhaled or oral hormone preparations are the first line of treatment for chronic pharyngitis. However, this therapeutic regimen is not satisfactory enough. At present, medicinal plants as dietary supplements or functional foods are widely recognized for the treatment and prevention of different diseases.Purpose: This study aimed to evaluate the efficacy of the botanical lozenge made from several medicinal plant extracts in the treatment of chronic pharyngitis and its effects on patients’ illness perception and adherence to treatment.Methods: Patients with chronic pharyngitis were randomly assigned to the experimental group (n = 52) or the control group (n = 51). Patients were given botanical lozenges prepared from the extracts of medicinal plants such as Siraitia grosvenorii (Swingle) C. Jeffrey ex A.M.Lu and Zhi Y. Zhang [Cucurbitaceae; Siraitiae fructus], Lonicera japonica Thunb [Caprifoliaceae; Lonicerae japonicae flos], Platycodon grandiflorus (Jacq.) A. DC [Campanulaceae; Platycodon radix], and Glycyrrhiza uralensis Fisch. ex DC [Fabaceae; Glycyrrhizae radix et rhizoma] or placebos made of starch for 15 days. The improvement of pharyngeal symptoms and signs, illness perception, and adherence to treatment were evaluated at the end of the intervention.Results: The total score of pharyngeal symptoms of patients in the experimental group (3.33 ± 2.33) was significantly lower than that in the control group (5.20 ± 2.93) (p &lt; 0.01). In comparison to the control group (3.43 ± 1.43), the total pharyngeal signs score of patients in the experimental group (2.69 ± 1.59) was considerably lower (p &lt; 0.01). The improvement rates of pharyngeal itching, dry throat, pharyngeal foreign body sensation, aggravation due to excessive speaking, and congestion of pharyngeal mucosa in the experimental group were 73.81%, 67.50%, 67.57%, 65.22% and 44%, respectively, which were significantly higher than those in the control group (p &lt; 0.05). In addition, patients taking botanical lozenges had better illness perception and adherence to treatment than those taking placebos (p &lt; 0.05). Patients with low adherence to treatment showed less personal control, concerns, and understanding of chronic pharyngitis (p &lt; 0.05).Conclusion: Botanical lozenges not only aided patients in recovering from chronic pharyngitis but also improved their positive perceptions of the disease, which helped them adhere to their treatment regimen.Clinical Trial Registration: [https://www.chictr.org.cn/], identifier [ChiCTR2200062139].
Families adapting to COVID-19 in urban Bangladesh: “It felt like the sky fell apart and we were in shock”
Authors: Nandonik Ahmed Jojan , Das Pooja Shangjucta , Kabir Zarina Nahar , Kiriam Shoshannah 
Published: March 2024

BackgroundThe COVID-19 epidemic has especially impacted the urban population in Bangladesh. Studies on COVID-19 have primarily focused on the patient’s perspective. It is important to understand the experience of family members who adopt caregiving roles, as the experience of COVID-19 also impacts, and is impacted by, household members. This study aimed to explore the challenges, preventative practices, health-seeking behaviour, and perspectives of navigating the health care system from the perspective of family members of persons who had recovered from COVID-19 during its initial outbreak in Bangladesh.MethodsParticipants of this qualitative study were family members (n = 7) of persons who had recovered from COVID-19 (either suspected or confirmed). Semi-structured in-depth interviews were conducted over telephone. Thematic analysis was used to analyse the data.ResultsAnalysis revealed three key themes: changes in everyday practices and choice of health care, challenges and constraints, and unexpected positive outcomes. All the themes had temporal dimension to them with four distinct phases: early stage of COVID-19, strict lockdown phase, COVID-19 diagnosis and illness period and post COVID-19 recovery.ConclusionThe importance of maintaining social contact for psychological wellbeing during critical times was evident in the study. Online communication and social media enabled participants to remain ‘socially connected’ which further supported their mental health. Increased attention to hygiene practices both before, during and subsequent to COVID-19 infections within families was reported. Physical distancing in case of a suspected or confirmed COVID-19 case was found logistically and socially impractical in a densely populated city.
Monolingual and bilingual infants' attention to talking faces: evidence from eye-tracking and Bayesian modeling
Authors: Lemonnier Sophie , Fayolle Benjamin , Sebastian-Galles Nuria , Brémond Roland , Diard Julien , Fort Mathilde 
Published: March 2024

IntroductionA substantial amount of research from the last two decades suggests that infants' attention to the eyes and mouth regions of talking faces could be a supporting mechanism by which they acquire their native(s) language(s). Importantly, attentional strategies seem to be sensitive to three types of constraints: the properties of the stimulus, the infants' attentional control skills (which improve with age and brain maturation) and their previous linguistic and non-linguistic knowledge. The goal of the present paper is to present a probabilistic model to simulate infants' visual attention control to talking faces as a function of their language learning environment (monolingual vs. bilingual), attention maturation (i.e., age) and their increasing knowledge concerning the task at stake (detecting and learning to anticipate information displayed in the eyes or the mouth region of the speaker).MethodsTo test the model, we first considered experimental eye-tracking data from monolingual and bilingual infants (aged between 12 and 18 months; in part already published) exploring a face speaking in their native language. In each of these conditions, we compared the proportion of total looking time on each of the two areas of interest (eyes vs. mouth of the speaker).ResultsIn line with previous studies, our experimental results show a strong bias for the mouth (over the eyes) region of the speaker, regardless of age. Furthermore, monolingual and bilingual infants appear to have different developmental trajectories, which is consistent with and extends previous results observed in the first year. Comparison of model simulations with experimental data shows that the model successfully captures patterns of visuo-attentional orientation through the three parameters that effectively modulate the simulated visuo-attentional behavior.DiscussionWe interpret parameter values, and find that they adequately reflect evolution of strength and speed of anticipatory learning; we further discuss their descriptive and explanatory power.
Two New and One First Recorded Species of Xylaria Isolated from Fallen Leaves in Hainan Tropical Rainforest National Park in China
Authors: Pan Xiaoyan , Chen Zongzhu , Lei Jinrui , Chen Xiaohua , Wu Tingtian , Li Yuanling , Chen Yiqing 
Published: March 2024

Xylaria is a widely distributed genus in the Ascomycota phylum that can decompose wood. It is an essential decomposer in ecosystems and a source of bioactive secondary metabolites. Based on morphological characteristics and molecular evidence, this article thoroughly describes two new species discovered on the fallen leaves in Hainan Tropical Rainforest National Park, along with illustrations and comparisons with similar species. Xylaria diaoluoshanensis is characterized by filamentous stromata with long infertile apexes, ascospores sometimes with non-cellular appendages. Xylaria fulvotomentosa differentiates itself from other Xylaria species that grow on fallen leaves by its stroma surface, being yellow tomentose. These two new species of the genus Xylaria were found by phylogenetic analysis using the ITS-β-tubulin-RPB2 sequence dataset. Furthermore, a species first discovered in China, X. petchii, is described. Finally, a search table for 44 species related to fallen leaves and petioles in the world is established.
L’Allemagne dans les autobiographies de germanistes français publiées depuis 1990
Authors: Genton François 
Published: March 2024

L’Allemagne dans les autobiographies des germanistes français publiées depuis 1990.
Depuis la fin du « court vingtième siècle » (E. Hobsbawm) ont paru plusieurs livres à caractère autobiographique écrits par des germanistes français. Les auteurs, Pierre Bertaux, Pierre Grappin, Joseph Rovan et Alfred Grosser, sont nés entre 1907 et 1925. Quelle vision de l’Allemagne leurs livres déploient-ils ? Une vision fondée sur un point de vue français, sur un attachement « premier » aux paysages de France et surtout à la langue et à la culture françaises, telles que les transmettait l’école de la IIIe République. Ces auteurs ont tous souffert du nazisme. À l’exception peut-être de Pierre Bertaux, ils manifestent tout de même un attachement « second » à l’Allemagne, à ses poètes (Grappin), à ses musiciens (Grosser), à ses villes et ses paysages (Rovan, Grappin), à ses intellectuels, aux institutions et au personnel politique de la RFA (Rovan, Grosser). Seul Pierre Grappin a aussi entretenu, dans les années 70 et 80, des relations suivies avec des chercheurs de RDA. Pierre Bertaux n’a pas vécu la chute du Mur de Berlin, Pierre Grappin s’est réjoui de la perspective d’une Europe apaisée. Aujourd’hui, Joseph Rovan plaide pour une Europe fédérant des nations bien trop petites pour s’imposer face aux grandes puissances tandis qu’Alfred Grosser rappelle aux Français et aux Allemands qu’ils ne sont pas le centre du monde et qu’ils ont beaucoup à apprendre les uns des autres.
La Prusse orientale de Michel Tournier
Authors: Schmitt Evelyne 
Published: March 2024

Michel Tourniers Ostpreußen.
Die deutschen Schriftsteller aus den ehemaligen Ostgebieten evozieren das Land der Kindheit unter dem doppelten Zeichen der Sehnsucht und der Schuld. Durch seine «Umschreibung» («réécriture») verfährt Michel Tournier in Le Roi des Aulnes nicht viel anders. Er bearbeitet eine Landschaft, die schon in der Phantasie des Lesers besteht und skizziert die beiden «Profile» Deutschlands. Ostpreußen, wo Mythos und Geschichte, Mensch und Natur aufeinandertreffen, ist das Land, in welchem Abel Tiffauges sich auf die Suche nach dem eigenen Ursprung machen kann. Die Provinz erscheint als eine in sich geschlossene Welt, wo sich Tourniers große Themen entwickeln können.
La chanson nationaliste de 1871 à 1914 ou la chanson d’une guerre à l’autre
Authors: Rassendren Yves 
Published: March 2024

La guerre de 1870 et ses répercussions déclenchent en France une vive réaction nationaliste dont la chanson sera le miroir mais aussi la sève. S’inscrivant dans la tradition des chansons politiques, la chanson nationaliste, exacerbe les sentiments revanchards et alimente la haine de l’ennemi.
Par des moyens simplistes mais efficaces, timbres déjà connus, paroles percutantes ou larmoyantes, ce genre devient un outil politique aux fins parfois xénophobes ou antisémites et connaîtra des avatars jusqu’après la Première Guerre mondiale.
Les connotations d'un hymne national « Réveille-toi, Roumain »
Authors: Melian Alexandru 
Published: March 2024

L’exposé propose un double aperçu sur le thème en débat : d’une part, la guerre reflétée dans les chansons populaires (la dimension folklorique) et, d’autre part, les connotations guerrières, plutôt révolutionnaires, de l’hymne national roumain (la dimension culte) .
Tandis que les premières, — en valorisant la ligne mélodique de doina (une complainte spécifique à la musique populaire roumaine) — exprime la douleur de la séparation, le dor de tous ceux qui sont restés loin, la révolte contre la guerre et contre ceux qui l’ont provoquée, l’hymne national, — dans la tradition des chansons de caserne et révolutionnaires, avec leur rythme de marche — transmet l’hommage à la liberté nationale et l’appel contre la tyrannie, contre l’esclavage.
L’analyse du verbe a(se)destepta met en évidence des ouvertures sémantiques qui expliquent la pérennité de cette chanson, devenue hymne national.
Le mythe habsbourgeois de la coexistence harmonieuse des nationalités et ses principes antagonistes. Le colonialisme et le nationalisme
Authors: Le Rider Jacques 
Published: March 2024

Der Habsburgermythos von der harmonischen Koexistenz der Nationalitäten und seine antagonistischen Prinzipien: Kolonialismus und Nationalismus.
Für den ganzen Donauraum hatte die territoriale Expansion der Habsburger Monarchie in Folge der Kriege gegen die Türken und später der Polen-Aufteilung zwischen Österreich, Preußen und Russland eine vereinheitlichende, im regionalen Sinne des Wortes ,,globalisierende Funktion“. Das Ost-West-Gefälle wurde ab dem letzten Drittel des 19. Jahrhunderts tendenziell geringer.
Zugleich aber brachte die „Globalisierung“ innerhalb des habsburgischen Donauraums neue soziale Ausdifferenzierungen und gesellschaftliche Diskurse quasi-kolonialen Typs. Die nationalen Ideologien versprachen als Reaktion auf die „zivilisatorische Herrschaft“ der Habsburger eine gesicherte Existenzform in neu zu konstruierenden, „imaginären Gemeinschaften.“
Diese historische Ambivalenz prägt die historische Erbschaft der Habsburger Monarchie: Einerseits war sie als integrierende und „globalisierende“ Imperialmacht ein Laboratorium für die Gegenwart, die in der Osterweiterung der EU eine vorrangige Aufgabe erblickt; andererseits war sie die „Versuchsstation des Weltuntergangs“ (Karl Kraus), in diesem Falle des Umschwungs von Globalisierung in den allgemeinen Kampf der kulturellen Identitäten.
Une Bavière revisitée : le « nouveau » Heimatfilm
Authors: Guillard Gilbert 
Published: March 2024

Zurück nach Bayern: der „neue“ Heimatfilm.
Im Zuge des „jungen deutschen Films“ der sechziger Jahre drehen Regisseure sogenannte neue Heimatfilme, die sowohl eine politisch-soziale Kritik wie eine ästhetische Revolution bezwecken. „Neu“ bedeutet jedoch nicht Erneuerung, sondern Demontage (Anti-Heimatfilm). Es geht darum, anders zu filmen und den reaktionären Diskurs des Heimatfilms und deren Hersteller bloßzustellen. Jagdszenen in Niederbayern von Peter Fleischmann (1968) ist nicht nur eine Darstellung, im Sinne der Karikatur, der Sitten und sozialen, politischen und religiösen Ideologie des ländlichen Bayerns, sondern auch eine allgemeine Infragestellung der modernen Gesellschaft. Die Themen (Gastarbeiter, Stellung der Frau, Homosexualität) werden so behandelt, daß die auf Gewalt begründete Art und Weise, wie eine doppelbödige Gemeinschaft funktioniert, dargelegt wird, auch um zu zeigen, daß der Begriff Heimat eigentlich keine höhere Werte beinhaltet.
Unveiling the Shadows - Corporate Greenwashing and its Multifaceted Impacts on Environment, Society, and Governance - A Macro Economic Theoretical Assessment
Authors: Yoganandham G , Abdul Kareem A , Mohammed Imran Khan E 
Published: March 2024

This article delves into the intricate relationship between ethical business practices, sustainable development, and the pervasive issue of corporate greenwashing. As organizations increasingly strive to align themselves with environmentally friendly and socially responsible initiatives, the phenomenon of greenwashing has emerged as a significant challenge. This article explores the profound impacts of greenwashing on the environment, society, and governance, shedding light on the implications for sustainable development. Through a comprehensive analysis, the article aims to raise awareness, encourage transparency, and promote genuine commitment to ethical business practices.Corporate greenwashing is a dishonest strategy by businesses to project environmental responsibility, causing damage, biodiversity loss, resource depletion, and climate change. To prevent, businesses, governments, NGOs, and consumers must work together.
This paper presents a study on corporate greenwashing, utilizing secondary sources and a cross-disciplinary approach. It provides recommendations for data collection, ethical guidelines, and presentation, ensuring effective results and conclusions. Despite the aforementioned, the main aim of this research article is to do a macroeconomic theoretical analysis of Unveiling the Shadows - Corporate Greenwashing and Its Multifaceted Impacts on Environment, Society, and Governance. The current situation is important to society and the economy.
Greenwashing or Game Changer of Corporatesustainability: Impact on Environment, Society, and Governance (ESG)
Authors: Kamini Varsha A , Ravi V , Manickam Thirupathi 
Published: March 2024

The argument raised in green washing research that the voluntary CESR (Corporate Environmental Social Responsibility) approach stimulates the spread of greenwashing is our keyfinding leading to ourtheory contribution. The voluntary idea of CESR remains popular in CESR literature and searches to be an unclear field which allows for misleading 'green' communication. As public awareness about green washing has increased over the last two decades, likewise has academic research, and there is now a significant amount of researchaddressing greenwashing issues. In this paper, we analyse and evaluate green washing research to provide a review of trends and progress in the field and an overview of the empirical andtheoretical findings reported in previous studies. As a result, we argue that greenwashing couldbe better prevented through a combination of voluntary and mandatory approaches. The freshapproach should encourage innovative and compelling corporate CESR activities while definingthe boundaries and regulations for their achievements and communication, as companies may break legislation by over stretching CESR reports. They are vulner able to the phenomena recognised in the literature as "green washing" because of their stake holders' perceptions. Consequently, this paper aims to exam in ethephenomena of green washing and trace its development in the current body of research.
Sustaining Growth: Mapping the Rural Market Ecosystem with Innovative Marketing
Authors: Agrawal Mohit , Chaurasia Ankit 
Published: March 2024

Sustaining growth in the context of rural markets involves a multifaceted approach that intertwines understanding the market ecosystem with innovative marketing strategies. The rural landscape, often characterized by diverse demographics, unique socio-economic challenges, and distinct consumer behaviors, presents both opportunities and complexities for businesses aiming to paper aims to explore the critical components of sustaining growth in rural markets, emphasizing the significance of mapping the rural market ecosystem and deploying innovative marketing approaches to effectively engage and serve these populations.
The analysis delves into the fundamental pillars of mapping the rural market ecosystem, highlighting the importance of understanding the cultural nuances, economic structures, and infrastructural dynamics within these regions. This comprehension serves as the groundwork for tailoring marketing strategies that resonate with the needs, aspirations, and lifestyles of the rural populace.
Furthermore, the paper discusses the challenges faced by businesses seeking to enter or expand within rural markets, encompassing issues related to distribution networks, last-mile connectivity, and establishing trust among rural consumers. Addressing these challenges necessitates a strategic blend of traditional and modern marketing techniques, coupled with an emphasis on building relationships within these communities.
The paper draws insights from diverse sources, including academic research, industry case studies, and expert opinions, to present a comprehensive overview of sustaining growth in rural markets through innovative marketing. It aspires to guide businesses and marketers in navigating the intricate landscape of rural economies, fostering sustainable and mutually beneficial relationships between companies and rural consumers.