bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use and Utility of Patient After‐Visit Instructions at a University Rheumatology Outpatient Clinic: Status and Randomized Prospective Pilot Intervention Study
Authors: Joseph Dijo , Hu Rong , Min Robert , Jolly Meenakshi , Hassan Sobia 
Published: February 2024

ObjectiveThe aim of this study was to evaluate the use of after‐visit instructions (AVIs) in an academic rheumatology clinic and assess the impact of standardized AVIs (sAVIs) and teach‐back (TB) on comprehension of health information.MethodsA retrospective review of adult patients seen between October 1 and 8, 2021, at the rheumatology clinic collected data on patient demographics, clinical features, and the presence, content, and readability of AVIs. During a subsequent prospective proof‐of‐concept study, routinely scheduled patients seen at the rheumatology clinic were randomized into three groups: control (received standard of care), received sAVIs only, and received sAVIs plus TB. Patients completed a health literacy questionnaire, satisfaction survey, and a one‐ to two‐week postvisit telephone survey to assess AVI comprehension.ResultsOut of 316 retrospective patient visits, 82 (25.9%) received AVIs. Among 210 of 316 patients (66.5%) with management changes, 76 (36.1%) received AVI, with 74.2% of the instructions considered concordant with the provider's note. Use of AVIs was higher with management changes, new patient visits, and medical trainee/teaching clinics. AVIs were written at a median 6.8 grade level. A total of 75 patients completed the prospective study: 31 (41.3%) were in the control group, 19 (25.3%) were in the group that received sAVIs only, and 25 (33.3%) were in the group that received AVIs with TB. There were no differences in overall postvisit survey comprehension/retention scores among the three patient groups evaluated.ConclusionAlthough a lack of AVI use was identified, implementation of sAVIs did not appear to impact patient retention or comprehension of discharge health information.
Two‐Alloys‐Layer Modified Current Collector toward the Efficient Plating/Stripping of Sodium in Ester‐Based Electrolyte
Authors: Jin Fan , Wang Ruijie , Wang Bo , Zhang Zekun , Wang Lei , Yang Jing , Li Cheng , Zhang Nan , Bao Changyuan , Wang Dianlong , Liu Huakun , Dou Shixue 
Published: February 2024

AbstractSodium metal anode is considered the most promising alternative to lithium due to its cost‐effectiveness and widespread availability. To realize its practical applications, numerous strategies have been devised in metallic Na and electrolyte to enhance the cycle life. However, the improvements in 2D current collector in ester‐based electrolyte remain limited. Herein, a two‐alloys‐layer modified current collector (Na15Sn4/Cu6Sn5/Cu) has been constructed through electrodeposition and sodiation processes. The Na15Sn4/Cu6Sn5 alloys‐layer guarantees the dense plating of Na and establishes a credible connection between Na and substrate. The failure of sodium anode is attributed to the depletion of ester‐based electrolyte resulting from their side reactions, which could be mitigated on Na15Sn4 surface. Thus, the asymmetric cell, containing merely 100 µL electrolyte, achieves efficient Na plating/stripping for 110 times with an average Coulombic efficiency of 94.9%, which is superior than those reported using excessive fluorine‐rich electrolytes. The full cell consisting of an anode with 3 mAh cm−2 of Na on Na15Sn4/Cu6Sn5/Cu and a Na3V2(PO4)3 cathode demonstrates a capacity retention rate of 96% after 200 cycles at 1.0 C. By improving the Coulombic efficiency solely through the modified copper foil, this work provides a new route for the practical application of Na anode in ester‐based electrolytes.
A Bionic Thermosensitive Sustainable Delivery System for Reversing the Progression of Osteoarthritis by Remodeling the Joint Homeostasis
Authors: Tong Min‐Ji , Song Meng‐Xiong , Liu Zhe , Yu Wei , Wang Chen‐Zhong , Cai Chuan‐Dong , Zhang Ying‐Kai , Zhang Yue‐Qi , Wang Li‐Peng , Zhu Zhen‐Zhong , Yin Xiao‐Fan , Yan Zuo‐Qin 
Published: February 2024

AbstractAlthough the pathogenesis of osteoarthritis (OA) is unclear, inflammatory cytokines are related to its occurrence. However, few studies focused on the therapeutic strategies of regulating joint homeostasis by simultaneously remodeling the anti‐inflammatory and immunomodulatory microenvironments. Fibroblast growth factor 18 (FGF18) is the only disease‐modifying OA drug (DMOAD) with a potent ability and high efficiency in maintaining the phenotype of chondrocytes within cell culture models. However, its potential role in the immune microenvironment remains unknown. Besides, information on an optimal carrier, whose interface and chondral‐biomimetic microenvironment mimic the native articular tissue, is still lacking, which substantially limits the clinical efficacy of FGF18. Herein, to simulate the cartilage matrix, chondroitin sulfate (ChS)‐based nanoparticles (NPs) are integrated into poly(D, L‐lactide)‐poly(ethylene glycol)‐poly(D, L‐lactide) (PLEL) hydrogels to develop a bionic thermosensitive sustainable delivery system. Electrostatically self‐assembled ChS and ε‐poly‐l‐lysine (EPL) NPs are prepared for the bioencapsulation of FGF18. This bionic delivery system suppressed the inflammatory response in interleukin‐1β (IL‐1β)‐mediated chondrocytes, promoted macrophage M2 polarization, and inhibited M1 polarization, thereby ameliorating cartilage degeneration and synovitis in OA. Thus, the ChS‐based hydrogel system offers a potential strategy to regulate the chondrocyte‐macrophage crosstalk, thus re‐establishing the anti‐inflammatory and immunomodulatory microenvironment for OA therapy.
Giant X‐Ray Circular Dichroism in a Time‐Reversal Invariant Antiferromagnet
Authors: Okamoto Jun , Wang Ru‐Pan , Chu Yen‐Yi , Shiu Hung‐Wei , Singh Amol , Huang Hsiao‐Yu , Mou Chung‐Yu , Teh Sukhito , Jeng Horng‐Tay , Du Kai , Xu Xianghan , Cheong Sang‐Wook , Du Chao‐Hung , Chen Chien‐Te , Fujimori Atsushi , Huang Di‐Jing 
Published: February 2024

AbstractX‐ray circular dichroism, arising from the contrast in X‐ray absorption between opposite photon helicities, serves as a spectroscopic tool to measure the magnetization of ferromagnetic materials and identify the handedness of chiral crystals. Antiferromagnets with crystallographic chirality typically lack X‐ray magnetic circular dichroism because of time‐reversal symmetry, yet exhibit weak X‐ray natural circular dichroism. Here, the observation of giant natural circular dichroism in the Ni L3‐edge X‐ray absorption of Ni3TeO6 is reported, a polar and chiral antiferromagnet with effective time‐reversal symmetry. To unravel this intriguing phenomenon, a phenomenological model is proposed that classifies the movement of photons in a chiral crystal within the same symmetry class as that of a magnetic field. The coupling of X‐ray polarization with the induced magnetization yields giant X‐ray natural circular dichroism, revealing typical ferromagnetic behaviors allowed by the symmetry in an antiferromagnet, i.e., the altermagnetism of Ni3TeO6. The findings provide evidence for the interplay between magnetism and crystal chirality in natural optical activity. Additionally, the first example of a new class of magnetic materials exhibiting circular dichroism is established with time‐reversal symmetry.
Modular Protein Fibers with Outstanding High‐Strength and Acid‐Resistance Performance Mediated by Copper Ion Binding and Imine Networking
Authors: Wang Mengyao , Yang Zhenyue , Jia Bo , Qin Dawen , Liu Yawei , Wang Fan , Sun Jing , Zhang Hongjie , Li Jingjing , Liu Kai 
Published: February 2024

AbstractEngineered protein fibers are promising biomaterials with diverse applications due to their tunable protein structure and outstanding mechanical properties. However, it remains challenging at the molecular level to achieve satisfied mechanical properties and environmental tolerance simultaneously, especially under extreme acid conditions. Herein, the construction of artificial fibers comprising chimeric proteins made of rigid amyloid peptide and flexible cationic elastin‐like protein (ELP) module is reported. The amyloid peptide readily assembles into highly organized β‐sheet structures that can be further strengthened by the coordination of Cu2+, while the flexible ELP module allows the formation of imine‐based crosslinking networks. These double networks synergistically enhance the mechanical properties of the fibers, leading to a high tensile strength and toughness, overwhelming many reported recombinant spidroin fibers. Notably, the coordination of Cu2+ with serine residues could stabilize β‐sheet structures in the fibers under acidic conditions, which makes the fibers robust against acid, thus enabling their successful utilization in gastric perforation suturing. This work highlights the customization of double networks at the molecular level to create tailored high‐performance protein fibers for various application scenarios.
High‐Performance Mesoporous Catalysts of Ultrasmall Hexagonal Thiospinel Nanocrystals for Visible‐Light Hydrogen Evolution
Authors: Andreou Evangelos K. , Vamvasakis Ioannis , Armatas Gerasimos S. 
Published: February 2024

AbstractSemiconductor nanocrystals are at the frontier of energy conversion research owing to their tunable optoelectronic attributes and versatile surface activities. Here high‐surface‐area mesoporous frameworks comprising linked CdIn2S4 nanocrystals as efficient catalysts are presented for visible‐light‐driven hydrogen production. X‐ray total scattering analysis discloses hexagonally‐structured CdIn2S4 thiospinel nanoparticles forming the porous structure. Further analytic results indicate that these newly‐made ensembles possess an open‐up architecture that is highly conductive and susceptible to modification. Through appropriate selection of the synthesis conditions, it is demonstrated that the present synthetic protocol is general, allowing the preparation of porous materials from thiospinel nanoparticles with various sizes and compositions. This study shows that coupling of CdIn2S4 mesostructures and Ni2P nanosheets substantially expedites the kinetics of water photo‐splitting by effectively reinforcing the separation of photogenerated carriers at the interfaces. Thus, mesoporous Ni2P/CdIn2S4 heterojunctions instigate a remarkable improvement in the hydrogen generation rate (≈29.3 mmol h−1 gcat−1), presenting an apparent quantum yield of 61.7% at 420 nm monochromatic light. A combination of electrochemical and spectroscopic studies unveils a pertinent mechanistic link between the charge‐transfer dynamics and intrinsic photochemical activity in these nanostructures.
Wearable Sweat Management Technologies
Authors: Wei Lei , Li Zhen , Dai Zongxian , Ding Lihua , Wei Hongjian , Li Jun , Zhu Hui , Zhu Yong 
Published: February 2024

AbstractThe aging population and increasing prevalence of diseases among younger individuals have heightened the pressing demand for wearable health monitoring devices among the general public. In comparison to self‐health monitoring at physical signal level, wearable biochemical monitoring can provide more comprehensive and insightful information regarding one's own health status. Wearable sweat‐sensing technologies hold great potential for non‐invasive and continuous biochemical monitoring, and have emerged as a focal point of wearable health monitoring research. The effective management of sweat, encompassing convenient induction, reliable collection, and efficient flow control and storage, is fundamental in wearable sweat sensing. To elucidate the research progression in these aspects, this review first summarizes sweat secretion mechanisms, induction method, and sampling mode. Additionally, detailed summaries and discussion on sweat sampling and transport modes are provided. Furthermore, within the context of epidermal microfluidics, the technologies on sweat flow control and storage management based on microvalves are discussed. Lastly, current commercialization and key challenges are summarized.
Radiative‐Recombination Thermodynamics in Boron‐Doped Diamond
Authors: Cheng Lu , Wu Yanlin , Zheng Wei 
Published: February 2024

AbstractBoron‐doped diamond is a wide‐bandgap semiconductor with excellent semiconductor properties, which is widely utilized in various applications. Till now, the thermodynamic rules governing the carrier transitions in this material have not been fully understood. In this research, the different luminescence behaviors of boron‐doped diamond under 193 nm pulse laser with high‐ and low‐ power density excitation are analyzed. Under high‐power density excitation (@≈63 kW cm−2), the emission intensity of excitons is nearly ten times higher than that of defect luminescence. Conversely, under low‐power density excitation (@≈1.4 kW cm−2, different emission peaks exhibit similar intensities, indicating a competitive relationship among them. Based on experimental and theoretical analyses, the difference is attributed to the thermodynamic distribution of carriers at varying excitation powers. Specifically, high excitation power brings an independent behavior of each emission peak, and the exciton emission is described by a phonon‐assisted radiation model; different from that, the competition among different emission centers under the condition of low excitation power cannot be neglected, and now the thermodynamic evolution of each emission peak is described by a carrier trapping‐dissociation model.
A responsive supramolecular hydrogel with robust mechanical properties for actuator and strain sensor
Authors: Huang Yuekai , Dong Zhixian , Wu Mali , Lei Caihong 
Published: February 2024

AbstractResponsive hydrogels hold great promise for applications such as biological tissue engineering, controlled drug release, soft actuators, and intelligent sensors. However, the design and construction of robust responsive hydrogels using a simple method remains a significant challenge. Herein, a non‐covalently crosslinked responsive hydrogel was constructed by introducing carboxyl‐Zr4+ metal coordination to the hydrophobic association network of P(AA‐co‐LMA) hydrogel through a facile one‐pot polymerization method. The incorporation of multiple reversible interactions, including hydrogen bonding, metal coordination, and hydrophobic association, resulted in a responsive hydrogel with exceptional mechanical strength (≈2.92 MPa), outstanding flexibility (elongation>1000%), and rapid response to pH alterations. Furthermore, the hydrogel also presented good ionic conductivity due to the abundant movable ions, as well as high sensitivity and stability. As application demonstrations, the supermolecular hydrogel had been successfully used in actuating and strain sensing. This work establishes an effective design strategy for creating tough and multifunctional responsive hydrogel.
Rational design of an iminocoumarin‐based fluorescence probe for peroxynitrite with high signal‐to‐noise ratio
Authors: Huang Zejian , Shi Lei , Liu Huihong , Zhou Zu‐Kun , Xiang Hua , Gong Shengzhao , Mao Guojiang , Shao Guang , Yang Sheng 
Published: February 2024

AbstractAs a high reactive oxygen species (ROS) and a reactive nitrogen species (RNS), peroxynitrite anion (ONOO−) is widely present in organisms and plays influential roles in physiological and pathological processes. It is of great significance to develop effective fluorescent probes for imaging peroxynitrite variation in living systems. Herein we present a novel fluorescent probe TQC0 for monitoring ONOO− based on the iminocoumarin platform, and this probe was synthesized by the knoevenagel condensation between a dihydropyridine‐salicylaldehyde derivative and 2‐benzothiazole‐acetonitrile, and subsequently masked with the boronate moiety. The obtained probe TQC0 exhibited a high signal‐to‐noise ratio (206‐fold) and a quick ‘turn‐on’ response (about 10 min) with great selectivity and sensitivity. Furthermore, the probe TQC0 was successfully applied for imaging ONOO− in living cells with low cytotoxicity.
Exploring a Solvent Dependent Strategy to Control Self‐Assembling Behavior and Cellular Interaction in Laminin‐Mimetic Short Peptide based Supramolecular Hydrogels
Authors: Kashyap Shambhavi , Pal Vijay Kumar , Mohanty Sweta , Roy Sangita 
Published: February 2024

AbstractSelf‐assembled hydrogels, fabricated through diverse non‐covalent interactions, have been extensively studied in regenerative medicines. Inspired from bioactive functional motifs of ECM protein, short peptide sequences have shown remarkable abilities to replicate the intrinsic features of the natural extracellular milieu. In this direction, we have fabricated two short hydrophobic bioactive sequences derived from the laminin protein i. e., IKVAV and YIGSR. Based on the substantial hydrophobicity of these peptides, we selected a co‐solvent approach as a suitable gelation technique that included different concentrations of DMSO as an organic phase along with an aqueous solution containing 0.1 % TFA. These hydrophobic laminin‐based bioactive peptides with limited solubility in aqueous physiological environment showed significantly enhanced solubility with higher DMSO content in water. The enhanced solubility resulted in extensive intermolecular interactions that led to the formation of hydrogels with a higher‐order entangled network along with improved mechanical properties. Interestingly, by simply modulating DMSO content, highly tunable gels were accessed in the same gelator domain that displayed differential physicochemical properties. Further, the cellular studies substantiated the potential of these laminin‐derived hydrogels in enhancing cell‐matrix interactions, thereby reinforcing their applications in tissue engineering.
Understanding the Reverse Water Gas Shift Reaction over Mo2C MXene Catalyst: A Holistic Computational Analysis
Authors: Dolz Daniel , De Armas Raúl , Lozano‐Reis Pablo , Morales‐García Ángel , Viñes Francesc , Sayós Ramón , Illas Francesc 
Published: February 2024

AbstractPristine Mo2C MXene has been proposed as an heterogeneous catalysis of the reverse water gas shift (RWGS) reaction. The present computational study aims at understanding its catalytic performance and reaction mechanisms tackling its thermodynamics, kinetics, and surface dynamic effects, combining Gibbs free energy profiles gained by density functional theory (DFT), mean‐field kinetics by microkinetic modeling, and rare‐event steps by kinetic Monte Carlo (kMC). The RWGS endergonicity goes for the use of high temperatures and reactants partial pressures to make the reaction exergonic. Gibbs free energy profiles show a preference for redox mechanism, whereas microkinetic simulations favor a low‐temperature preference of formate mechanism. The kMC reveals simultaneous operating redox and formate pathways, where surface coverage disfavors redox favoring the formate pathway. A peak performance is found at 700 K, in line with reported experiments, where the formation of surface O2* is found to be key, acting as a reservoir for O* adatoms while freeing surface sites upon O2* formation. Even though high turnover frequencies are predicted, the system could benefit from swing operando conditions, alternating CO production steps with H2 reduction regeneration steps, and/or ways to reduce the surface O2* and so to have more active catalytic sites.
Advancements, Challenges, and Pathways to Sustainable Biofuel Production
Authors: Din Muhammad Imran , Ameen Saba , Hussain Zaib , Khalid Rida 
Published: February 2024

AbstractThe discovery of new energy sources plays a vital role to fulfil the needs of energy and depletion of fossil fuel sources. An inclusive review of all available technologies for the synthesis of biofuels from biomass is presented. Amongst the innovative biomass conversion technologies, thermochemical technology encompasses significant potential practices and is required for expansion. Universally, biofuels are gaining importance due to the depletion of non‐renewable fuel sources in transport and industries by equivalent work proficiencies. The reaction mechanism thoroughly explores all aspects associated with reaction conditions, types of reactor, and products. Biomass thermochemical conversion technologies will be influential in producing sustainable biofuels.
Metal‐Organic Framework Based Sensors for Benzene Vapor
Authors: Li Wen‐Bin , Liang Gang , Chen De‐Jian , Ye Jia‐Wen , Liu Jie‐Wei , Li Jing , Shao Huai‐Yu , Mo Zong‐Wen , Chen Xiao‐Ming 
Published: February 2024

AbstractSensing of benzene vapor is a hot spot due to the volatile drastic carcinogen even at trace concentration. However, achieving convenient and rapid detection is still a challenge. As a sort of functional porous material, metal‐organic frameworks (MOFs) have been developed as detection sensors by adsorbing benzene vapor and converting it into other signals (fluorescence intensity/wavelength, chemiresistive, weight or color, etc.). Supramolecular interaction between benzene molecules and the host framework, aperture size/shape and structural flexibility are influential factors in the performance of MOF‐based sensors. Therefore, enhancing the host‐guest interactions between the host framework and benzene molecules, or regulating the diffusion rate of benzene molecules by changing the aperture size/shape and flexibility of the host framework to enhance the detection signal are effective strategies for constructing MOF‐based sensors. This concept highlights several types of MOF‐based sensors for the detection of benzene vapor.
Understanding the Electronic and Structural Effects in ORR Intermediate Binding on Anion‐Substituted Zirconia Surfaces
Authors: Sinha Sukanya , Vegge Tejs , Winther Kirsten T. , Hansen Heine Anton 
Published: February 2024

AbstractFor oxygen reduction reaction (ORR), the surface adsorption energies of O and OH* intermediates are key descriptors for catalytic activity. In this work, we investigate anion‐substituted zirconia catalyst surfaces and determine that adsorption energies of O and OH* intermediates is governed by both structural and electronic effects. When the adsorption energies are not influenced by the structural effects of the catalyst surface, they exhibit a linear correlation with integrated crystal orbital Hamiltonian population (ICOHP) of the adsorbate‐surface bond. The influence of structural effects, due to the re‐optimisation slab geometry after adsorption of intermediate species, leads to stronger adsorption of intermediates. Our calculations show that there is a change in the bond order to accommodate the incoming adsorbate species which leads to stronger adsorption when both structural and electronic effects influence the adsorption phenomena. The insights into the catalyst‐adsorbate interactions can guide the design of future ORR catalysts.