bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Expanded Palette of Fluorescent COS/H2S‐Releasing Donors for H2S Delivery, Detection, and In Vivo Application
Authors: Fosnacht Kaylin G. , Dorogin Jonathan , Jefferis Payton M. , Hettiaratchi Marian H. , Pluth Michael D. 
Published: April 2024

AbstractHydrogen sulfide (H2S) is an important reactive sulfur species that is involved in many biological functions, and H2S imbalances have been indicated as a potential biomarker for various diseases. Different H2S donors have been developed to deliver H2S directly to biological systems, but few reports include donors with optical responses that allow for tracking of H2S release. Moreover, donor systems that use the same chemistry to deliver H2S across a palette of fluorescent responses remain lacking. Here we report five thiol‐activated fluorescence turn‐on COS/H2S donors that utilize blue, yellow, orange, red, and near infrared‐emitting dyes functionalized with an H2S‐releasing sulfenyl thiocarbonate scaffold. Upon treatment with thiols, each donor provides a fluorescence turn‐on response (3–310‐fold) and high H2S release efficiencies (>60 %). Using combined electrode and fluorescence experiments, we directly correlate the measured H2S release with the fluorescence response. All donors are biocompatible and release H2S in live cell environments. In addition, we demonstrate that the NIR donor allows for imaging H2S release in live rats via subcutaneous injection of the donor loaded into an alginate gel, which to the best of our knowledge is the first in vivo tracking of H2S release from a fluorogenic donor in non‐transparent organisms.
Nanogels with Metal‐Organic Cages as Functional Crosslinks
Authors: Hu Chaolei , Severin Kay 
Published: April 2024

AbstractA dinuclear metal‐organic cage with four acrylate side chains was prepared by self‐assembly. Precipitation polymerization of the cage with N‐isopropylacrylamide yielded a thermoresponsive nanogel. The host properties of the cage were retained within the gel matrix, endowing the nanogel with the capability to serve as a sorbent for chloride ions in water. Moreover, a heteroleptic cage with the drug abiraterone as co‐ligand was integrated into a nanogel. The addition of chloride ions induced a structural rearrangement of the metal‐ligand assembly, resulting in the gradual release of abiraterone.
Evaluation of mechanical, permeation, and degradation properties of poly(hydroxybutyrate) blends for sustainable packaging
Authors: Ahuja Simran , Verma Amisha , Arora Sanjiv 
Published: April 2024

AbstractThis study explores the development of environmentally sustainable, high‐quality packaging materials by incorporating poly(hydroxybutyrate) (PHB) with different polymers. To accomplish this objective, pure PHB was blended with poly(ethylene glycol) (PEG) in a precise 9:1 ratio. Subsequently, this blend was further combined with 50 wt% of various polymers, namely, polycaprolactone, poly(vinylacetate), and polylactic acid (PLA), using a solvent‐casting method. Further, the research investigates the multifaceted properties of these materials, including their thermal characteristics, morphological structures, mechanical strengths, barrier properties, and degradation behaviors. Among these blends, the film consisting of PHB, PEG, and PLA (PHB/PEG/PLA) emerged as a standout performer, displaying exceptional attributes. Notably, the PHB/PEG/PLA composite film exhibited remarkable thermal stability, boasting a high tensile strength of 26.6 MPa. Additionally, it demonstrated an outstanding ability to serve as a barrier against water vapors. These findings imply that the PHB/PEG/PLA composite film holds significant potential for a wide range of applications, particularly in the field of packaging and beyond.
Enhancing coal slime processing: Investigating the efficacy of sodium dodecyl sulfonate in the adsorption on kaolinite surfaces
Authors: Lu Fangqin , Liu Lingyun , Kong Chuilei , Zhao Hongyu 
Published: April 2024

AbstractAddressing the issue of processing fine kaolinite and quartz particles in coal slime, this study utilized molecular simulation and Density Functional Theory (DFT) to investigate the chelate adsorption characteristics of sodium dodecyl sulfate (SDS) on kaolinite surfaces. As a major clay mineral component in coal slime, kaolinite reduces coal's calorific value but holds potential for industrial and agricultural applications. The research identified distinct interactions between SDS and the tetrahedral SiO layer and octahedral AlO layer of kaolinite, in contrast to quartz, which contains only the tetrahedral SiO layer. This difference is crucial for the effective separation of kaolinite from quartz. The study focused on analyzing SDS adsorption on the (001) and (00‐1) planes of kaolinite. The findings revealed strong adsorption of SDS on kaolinite surfaces, especially on the (001) plane, evidenced by significant charge transfer indicating efficient chelation. This effect results from the interaction of SDS's electron‐donating atoms (such as S and O) with the metal atoms on the surface of kaolinite. Adsorption strength was quantified through adsorption energy calculations, showing a stronger interaction on the (001) surface. Experimental validations, including single mineral flotation experiments and infrared spectroscopic analysis, further corroborated the simulation outcomes. These tests demonstrated improved flotation recovery of kaolinite in the presence of SDS and with reduced particle size. Infrared analysis revealed that SDS selectively and strongly adsorbs on kaolinite surfaces, as indicated by diminished hydroxyl group stretching vibrations in the FTIR spectrum and changes in absorption peaks related to inorganic vibrations and sulfonic acid groups. The study demonstrates that SDS can selectively and effectively adsorb onto kaolinite surfaces, particularly on the (001) plane, facilitating the efficient extraction of fine kaolinite from coal slime. This research holds significant potential for enhancing the utilization of resources from coal slime in the coal industry, offering both economic and environmental benefits.
Photo‐controllable cationic homopolymerization and random copolymerization of vinyl ethers based on iridium salt photocatalyst
Authors: Guo Penghui , Feng Xiaohu , Liu Ruofan , Ding Wei , Shi Qisong , Jin Yushun , Wu Yibo 
Published: April 2024

AbstractTemporal control of chain growth is a central challenge for photoinitiated active polymerization. In this work, we introduced an iridium salt complex‐based catalyst system to achieve fine temporal control of the chain growth process. By electrochemical analysis, compared with the pyran salt photocatalyst, it was found that the iridium salt complex could promote the chain transfer of active species to reversible addition‐fragmentation chain transfer polymerization (RAFT) reagent, thereby generating dormant species, which provided the possibility of time control of the polymerization process. Using this catalytic system, we successfully achieved homopolymerization of vinyl ethers with different substituents and random copolymerization with isobutyl vinyl ethers, which is not only pointed the way for broadening the monomer selection in the future, but also provided an innovative way to prepare new functionalized materials.
Synthesis, characterization, and biological study of new synthetic opioid hemorphin‐4 peptides containing sterically restricted nonnatural amino acids
Authors: Todorov Petar , Georgieva Stela , Trapella Claudio , Chakarov Kalin , Tchekalarova Jana , Pechlivanova Daniela , Cheshmedzhieva Diana , Fantinati Anna , Illuminati Davide 
Published: April 2024

AbstractSome new hemorphin‐4 analogs with structures of Xxx‐Pro‐Trp‐Thr‐NH2 and Tyr‐Yyy‐Trp‐Thr‐NH2, where Xxx is 2‐amino‐3‐(4−hydroxy‐2,6‐dimethylphenyl)propanoic acid or 2‐amino‐3‐(4‐dibenzylamino‐2,6‐dimethylphenyl)propanoic acid, and Yyy is (2S,4S)‐4‐amino‐pyrrolidine‐2‐carboxylic acid, were synthesized and characterized by electrochemical and spectral analyses. In vivo anticonvulsant and antinociceptive activities of peptide derivatives were studied after intracerebroventricular injection in mice. The therapeutic effects of the modified peptides on seizures and pain in mice were evaluated to provide valuable insights into the potential applications of the novel compounds. Electrochemical characterization showed that the compounds behave as weak protolytes and that they are in a soluble, stable molecular form at physiological pH values. The antioxidant activity of the peptides was evaluated with voltammetric analyses, which were confirmed by applying the 2,2‐Diphenyl‐1‐picrylhydrazyl method. The compounds showed satisfactory results regarding their structural stability, reaching the desired centers for the manifestation of biological activity without hydrolysis processes at 37°C and physiological pH. Dm‐H4 and H4‐P1 exhibited 100% and 83% potency to suppress the psychomotor seizures in the 6‐Hz test compared to 67% activity of H4. Notably, only the H4‐P1 had efficacy in blocking the tonic component in the maximal electroshock test with a potency comparable to H4. All investigated peptides containing unnatural conformationally restricted amino acids showed antinociceptive effects. The analogs Db‐H4 and H4‐P1 showed the most pronounced and long‐lasting effect in both experimental models of pain induced by thermal and chemical stimuli. Dm‐H4 produced a dose‐dependent thermal antinociception and H4‐P2 inhibited only formalin‐induced pain behavior.
Breaking Down the Barriers between the Digital and the Real: Mixed Reality Applied to Battery Manufacturing R&D and Training
Authors: Denisart Lucie , Troncoso Javier F. , Loup‐Escande Emilie , Franco Alejandro A. 
Published: April 2024

AbstractIn a scenario in which the manufacturing of high‐performance, safe batteries on an unprecedented large scale is crucial for the energy transition and fight against climate change, research laboratories and cell production industries are facing challenges due to the lack of efficient data management and training tools. In this context, the use of intelligent devices plays an important role on the path towards the optimization of the manufacturing process and the enhancement of the battery performance while reducing production costs. In this Concept, we present an innovative Mixed Reality tool for efficient data collection and training in real‐time in battery research laboratories and battery manufacturing pilot lines, which runs on Microsoft HoloLens 2 glasses. We report a deep analysis on its ergonomic and usability aspects, and describe how we solved the problems found during its development. Thanks to this tool, users can collect data while keeping their hands free and receive advice in real time to design and build batteries with tailored properties. This optimizes data management in battery manufacturing environments. Now, thanks to our Mixed Reality application, users can collect data in the place of work, save this data automatically on a server and exploit it to receive advice and feedback to support their decision‐making and learning of the manufacturing process.
Waldorf, Montessori und Pestalozzi‐Hype? – Schulnamen im Spiegel der Geschichte der Pädagogik
Authors: Engelmann Sebastian , Weiand Katharina 
Published: April 2024

AbstractSchools in Germany are frequently named after people. Thus, these persons are remembered in the public sphere. This article answers the question to what extent the school names in the federal state of Thuringia correspond with the history of scientific pedagogy. For this purpose, in a first step, the controversial discussion about key figures in pedagogy and history of education is presented. In a second step the entirety of all school names in Thuringia is considered and individual results are discussed. As a rule, it is not pedagogues who lend their names to schools but writers, artists and political figures. Only one fifth of all schools named after a person are named after educators. It is found that the key figures in pedagogy are rarely available as namesakes, whereas in practice successful school founders are preferred as name‐givers. Accordingly, the history of pedagogy is represented in a filtered way in school names. Based on these results, further research perspectives for research on school names are formulated.
Religious transmission and cultural negotiation in first‐generation Muslim migrant parents in Italy: A qualitative study
Authors: Miglietta Anna , El Brashy Dalia , Ricucci Roberta 
Published: April 2024

AbstractThis study investigated the interplay between acculturation and religion in the religious transmission of first‐generation Islamic parents in Italy. Based on the model of the Big Four Religious Dimension (BFRD) the study took a multidimensional approach to religiosity to gain a detailed understanding of the different facets of religiosity and their contribution to the overall process of cultural adaptation and intergenerational transmission of religious values. Eleven first‐generation Muslim parents (nine women; mean age: 48 years) participated in a semi‐structured interview. Results showed that the tension between the desire to ‘raise good Muslims’ and for their successful integration in a non‐Muslim context challenges different facets of religiosity opening spaces for cultural negotiation which leads parents to reconsider how religious rules and identity are passed on to second generation and to develop a more conscious approach to religiosity in migration. The ability to connect religious values and identity with the context of life was greater when parents have developed a balance between the dynamics of integration in the Italian or cross‐cultural spaces of everyday life and the spaces reserved for Muslims and had a high level of cultural capital. Practical implications for implementing policies of cultural and religious pluralism are discussed. Please refer to the Supplementary Material section to find this article's Community and Social Impact Statement.
An Updated Review on Functionalized Graphene as Sensitive Materials in Sensing of Pesticides
Authors: Pratap Singh Raman Anirudh , Thakur Gauri , Pandey Garima , Kumari Kamlesh , Singh Prashant 
Published: April 2024

AbstractNumerous chemical pesticides were employed for a long time to manage pests, but their uncontrolled application harmed the health and the environment. Accurately quantifying pesticide residues is essential for risk evaluation and regulatory purposes. Numerous analytical methods have been developed and utilized to achieve sensitive and specific detection of pesticides in intricate sampl es like water, soil, food, and air. Electrochemical sensors based on amperometry, potentiometry, or impedance spectroscopy offer portable, rapid, and sensitive detection suitable for on‐site analysis. This study examines the potential of electrochemical sensors for the accurate evaluation of various effects of pesticides. Emphasizing the use of Graphene (GR), Graphene Oxide (GO), Reduced Graphene Oxide (rGO), and Graphdiyne composites, the study highlights their enhanced performance in pesticide sensing by stating the account of many actual sensors that have been made for specific pesticides. Computational studies provide valuable insights into the adsorption kinetics, binding energies, and electronic properties of pesticide‐graphene complexes, guiding the design and optimization of graphene‐based sensors with improved performance. Furthermore, the discussion extends to the emerging field of biopesticides. While the GR/GO/rGO based sensors hold immense future prospects, and their existing limitations have also been discussed, which need to be solved with future research.
Sudan black poisoning resulted in methemoglobinemia in a baby with congenital chyloperitoneum
Authors: Padari Helgi , Kipper Karin , Eelmäe Imbi , Nerman Jekaterina , Lintrop Mare , Metsvaht Tuuli 
Published: April 2024

Key Clinical MessageTreatment of congenital chyloperitoneum is a challenge. Conservative methods may be ineffective. Preoperative visualization of the site of lymphatic leakage is crucial, but radiological imaging is technically complicated and may not provide sufficient information, especially in small patients. To ease the detection of lymphatic leakage during surgery, preoperative feeding with fat‐rich formula with Sudan Black has been recommended. However, administration of Sudan Black may result in life‐threatening methemoglobinemia and liver damage without any advantage of revealing leakage during surgery. We recommend preoperative feeding with pure fat‐rich formula.
Rare co‐occurrence of tonsillar follicular dendritic cell sarcoma and schizophrenia: A comprehensive study
Authors: Zhang Yu , Jin Xiaoxi , Lian Liyan 
Published: April 2024

AbstractThis study investigated the infrequent occurrence of tonsillar follicular dendritic cell sarcoma (FDCS) co‐existing with schizophrenia, presenting a comprehensive examination of clinical, pathological, and literature aspects. A systematic literature review was conducted, focusing on articles related to “schizophrenia” and “sarcoma,” with in‐depth analysis of included case reports. Clinical data, pathological findings, and patient follow‐up information were collected and synthesized. The study detailed a rare case of FDCS in the tonsil concurrent with schizophrenia, providing insights into diagnosis, treatment, and follow‐up. A literature review of combined FDCS in the tonsil and schizophrenia cases highlighted their clinical and pathological characteristics. Eight case reports encompassing 11 patients diagnosed with sarcoma and schizophrenia were included. Surgical resection was the preferred primary treatment, while chemotherapy was suggested for recurrences. Instances of co‐occurring FDCS and schizophrenia were exceptionally limited, with tonsillar FDCS being particularly uncommon. The coexistence of tonsillar FDCS and schizophrenia was an exceptionally rare condition, posing diagnostic and therapeutic challenges. This study contributed valuable insights into clinical and pathological practice through a systematic review, underscoring the significance of early diagnosis and comprehensive management.
Productivity Prediction for the Progressive Freeze Desalination Process Using Heat and Mass Transfer Modeling
Authors: Najim Abdul 
Published: April 2024

AbstractPredicting the productivity of the freeze desalination process is of key importance. This paper describes an analytical method to predict the productivity for the progressive freeze desalination process utilizing the rectangular channel crystallizer design. The mass of ice produced during the process is considered a measure of productivity. The model was developed using heat and mass transfer modeling. The effect of coolant temperature (from −8 to −16 °C), liquid flow rate (4400–6000 mL min−1), and initial salt concentration of the liquid (1.5–7 wt%) on the mass of ice produced was investigated. The analytical results of the mass of ice produced were compared with the experimental data. A plausible match was found between the analytical and experimental results, with an error range between 6 % and 9 %. The model can predict the mass of ice produced for given values of the initial salt concentration of the liquid, initial mass of the liquid, salt concentration of thawed ice, liquid flow rate, and coolant temperature.
Impact of tocilizumab on anti‐CD19 chimeric antigen receptor T‐cell therapy in B‐cell acute lymphoblastic leukemia
Authors: Wang Xiangmin , Zhang Bingpei , Zhang Qing , Zhou Hongyuan , Sun Qian , Zhou Yi , Li Tianci , Zhou Dian , Shen Ziyuan , Zhang Jiaoli , Li Ping , Liang Aibin , Zhou Keshu , Han Lu , Hu Yongxian , Yang Yun , Cao Jiang , Li Zhenyu , Xu Kailin , Sang Wei 
Published: April 2024

AbstractBackgroundTocilizumab is commonly used for the management of chimeric antigen receptor (CAR) T‐cell therapy–associated cytokine release syndrome (CRS). However, it remains unknown whether tocilizumab or its dosage affects the efficacy and safety of CAR T‐cell therapy. The objective of this multicenter retrospective study was to explore the impact of tocilizumab on CAR T‐cell therapy.MethodsIn total, 93 patients with B‐cell acute lymphoblastic leukemia (B‐ALL) receiving humanized anti‐CD19 CAR T cells were recruited from May 2016 to November 2022. Forty‐five patients received tocilizumab (tocilizumab group), whereas 48 patients did not (nontocilizumab group). Thirteen patients received >1 dose of tocilizumab. The primary end point was the effect of tocilizumab on the efficacy and safety of CAR T cells. Additionally, proliferation, killing, and cytokine assays of CAR T cells were performed in vitro in the presence of tocilizumab.ResultsThe median age of the patients was 33 years, with 47 males and 46 females. Patients in the tocilizumab group showed similar complete response (CR) rate, overall survival (OS), and event‐free survival (EFS) compared with the nontocilizumab group. Compared with patients who received ≤1 dose of tocilizumab, receiving >1 dose of tocilizumab did not affect their CR rate, OS, or EFS. In the tocilizumab group, all patients experienced CRS and 26.7% experienced immune effector cell–associated neurotoxicity syndrome (ICANS). In the nontocilizumab group, 64.6% of patients experienced CRS and 8.3% experienced ICANS. Up to 75% of ICANS and 87.5% of grade ≥3 ICANS occurred in the tocilizumab group. In vitro, tocilizumab did not impair the proliferation and killing effects of CAR T cells.ConclusionsTocilizumab does not affect the efficacy of CAR T cells but may increase the likelihood of ICANS.
A Novel Collagen Aerogel with Relevant Features for Topical Biomedical Applications
Authors: Batista Miguel P. , Schroeter Baldur , Fernández Naiara , Gaspar Frédéric Bustos , do Rosário Bronze Maria , Duarte Ana Rita , Gurikov Pavel 
Published: April 2024

AbstractCollagen‐based aerogels have great potential for topical biomedical applications. Collagen's natural affinity with skin, biodegradability, and gelling behavior are compelling properties to combine with the structural integrity of highly porous matrices in the dry form (aerogels). This work aimed to produce a novel collagen‐based aerogel and to perform the material‘s solid‐state and physicochemical characterization. Aerogels were obtained by performing different solvent exchange approaches of a collagen‐gelled extract and drying the obtained alcogels with supercritical CO2. The resulting aerogels showed a sponge‐like structure with a relatively dense mesoporous network with a specific surface area of 201–203 m2/g, a specific pore volume of 1.08–1.15 cm3/g, and a mean pore radius of ca. 14.7 nm. Physicochemical characterization confirmed that the obtained aerogels are composed of pure collagen, and the aerogel production process does not impact protein tertiary structure. Finally, the material swelling behavior was assessed at various pH values (4, 7, and 10). Collagen aerogels presented a high water uptake capacity up to ~2700 wt. %, pH‐dependent stability, and swelling behavior in aqueous media. The results suggest that this collagen aerogel could be a promising scaffold candidate for topical biomedical applications.