bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systemische Therapie von prämenopausalen Patientinnen mit hormonrezeptorpositivem, HER2-negativem Brustkrebs in den Frühstadien – Kontroversen und Standards in der Krankenversorgung
Authors: Müller Volkmar , Fasching Peter A. , Nabieva Naiba , Fehm Tanja N. , Thill Marc , Schmidt Marcus , Kühn Thorsten , Banys-Paluchowski Maggie , Belleville Erik , Juhasz-Böss Ingolf , Untch Michael , Kolberg Hans-Christian , Harbeck Nadia , Aktas Bahriye , Stickeler Elmar , Kreuzeder Julia , Hartkopf Andreas D. , Janni Wolfgang , Ditsch Nina 
Published: March 2024

ZusammenfassungDie adjuvante endokrine Behandlung von prämenopausalen Patientinnen mit einem
hormonrezeptorpositiven, HER2-negativen (HR-pos./HER2-neg.) Mammakarzinom unterliegt bei
bestehender Ovarialfunktion einigen Besonderheiten. Als therapeutische Optionen stehen
Tamoxifen mit oder ohne GnRH-Analogon und Aromatasehemmer mit GnRH-Analogon zur Verfügung. Des
Weiteren wird die Ovarialfunktion durch eine vorherige Chemotherapie beeinflusst. Sowohl die
Indikation für GnRH-Analoga in Kombination mit Tamoxifen als auch die Indikation für
Aromatasehemmer (+GnRH-Analoga) sind für Patientinnen mit einem erhöhten Rückfallrisiko
vorgesehen.In nationalen und internationalen Leitlinien und Therapieempfehlungen ist jedoch keine
klare Grenze für ein mittleres oder hohes Risiko definiert, sodass viele
Therapieentscheidungen für jede Patientin individuell getroffen werden. Dies spiegelt sich
auch in einer großen nationalen und internationalen Variabilität z. B. beim Einsatz von
Aromatasehemmern + GnRH-Analoga wider.Diese Übersichtsarbeit fasst die Datenlage zu den abgeschlossenen Studien (z. B. SOFT,
TEXT, EBCTCG-Metaanalysen), den aktuellen Multigentest-Studien (TailorX, RxPonder, ADAPT)
zusammen, diskutiert die Rationale für aktuell durchgeführte Studien (z. B. CLEAR-B) und gibt
einen Ausblick auf künftige Fragestellungen.
Bionische Chirurgie trifft Bionische Rekonstruktion – erstes in-human
Projekt von robotischer Mikrochirurgie zur Targeted Muscle
Reinnervation
Authors: Aman Martin , Struebing Felix , Mayrhofer-Schmid Maximilian , Harhaus Leila , Kneser Ulrich , Böcker Arne Hendrik 
Published: March 2024

ZusammenfassungRobotische Mikrochirurgie ist ein wachsendes Feld in der rekonstruktiven
Chirurgie und beinhaltet viele Vorteile wie eine optimale Ergonomie sowie eine
Reduktion des physiologischen Tremors. Allerdings sind bis zum heutigen
Zeitpunkt nur eine geringe Anzahl an robotischen Systemen verfügbar, die ein
mikrochirurgisches Arbeiten ermöglichen. Nach wie vor ist die Durchführung einer
robotischen mikrochirurgischen Nervenkoaptation eine Herausforderung in der
klinischen Praxis. Targeted Muscle Reinnervation (TMR) ist eine innovative
rekonstruktive Methode mit mehrfachen Nerventransfers zu den Muskeln des
Amputationsstumpfes, welche zum einen die Neuromentwicklung verhindern und zum
anderen die Anwendungsmöglichkeit einer bionischen Prothese verbessern sollen.
Robotische Mikrochirurgie ermöglicht ein hohes Maß an Präzision und die
Reduktion des physiologischen Tremors, verlangt jedoch hohe Investitionskosten
was eine große Herausforderung für unser Gesundheitssystem darstellt.
Zusammenfassend zeigt diese Studie die Möglichkeit der Anwendung von robotischer
Mikrochirurgie in der peripheren Nervenchirurgie, insbesondere für
Nerventransfers, bei denen eine präzise Durchführung in einem limitierten Platz
durchgeführt werden muss. Zukünftige Studien werden das Potenzial von
robotischer Mikrochirurgie für die peripheren Nervenchirurgen weiter evaluieren
müssen
Probabilistic Prediction of Gastrointestinal Ischemia after Cardiothoracic Surgery
Authors: Stephan Francois , Facque Mathilde , Salem Fares Ben , Picq Olivia , Imbert Audrey , Genty Thibaut , Zins Marc 
Published: March 2024

Abstract
Background Gastrointestinal ischemia (GIisch) is challenging to diagnose in patients after cardiothoracic surgery. Computed tomography angiography (CTA) carries substantial false-negative and false-positive rates. The aim of the study was to evaluate if a combination of readily available variables improves the diagnosis of GIisch after cardiothoracic surgery.
Methods This retrospective study included patients receiving intensive care after cardiothoracic surgery. GIisch was confirmed by surgical and/or endoscopic findings. A GIisch prediction score was developed using the Spiegelhalter-Knill-Jones system in a training cohort then tested in a validation cohort (patients without obvious signs of GIisch on CTA).
Results The training cohort comprised 125 consecutive patients with suspected GIisch in 2008 to 2019, including 85 with confirmed GIisch. CTA, performed in 92 patients, had a high false-negative rate of 17/60 (28%) and a lower false-positive rate of 7/32 (22%). The score included cardiopulmonary bypass, negatively associated with GIisch, and six variables positively associated with GIisch: intraoperative mean arterial pressure < 50 mm Hg, aspartate aminotransferase > 15 N, lactate increase in 24 hour > 20%, and 3 CTA findings, namely, bowel dilation, bowel wall thickening, and mesenteric vasoconstriction. The area under the receiver operating characteristic was 0.82 (95% confidence interval [CI], 0.51–0.93) in the training cohort and 0.82 (95% CI, 0.68–0.96) in the validation cohort (n = 34 patients). Reliability of the predicted probabilities was greatest for probabilities ≤ 30% or ≥ 70%.
Conclusion In patients receiving intensive care after cardiothoracic surgery, GIisch cannot be ruled out based solely on CTA findings. A scoring system combining CTA findings with other variables may improve the diagnosis of GIisch in this population.
2.1 Amide-Bond-Forming Reactions
Authors: Li Y. , Fang X. , Wang Y. 
Published: March 2024

AbstractAmide-bond-forming reactions are involved in at least one step in the preparation of most DNA-encoded chemical libraries (DELs) because of the versatility and DNA compatibility of these reactions. Amidation is typically achieved through the condensation of amines and carboxylic acids, which are two of the largest commercially available building-block pools because of their widespread use in medicinal chemistry for the synthesis of drug-like screening libraries.
2.2 Metal-Promoted DEL-Compatible C—C Bond Forming Reactions
Authors: Migliorini F. , Puglioli S. , Neri D. , Cazzamalli S. , Favalli N. 
Published: March 2024

AbstractDNA-encoded library (DEL) technology relies on the availability of robust and DNA-compatible chemical transformations. Metal-promoted C—C bond forming reactions are widely applied for the synthesis of fine chemicals such as pharmaceuticals. However, their application in DEL technology represents a challenge due to the use of metal catalysts, high temperatures, and organic solvents. In this chapter, we report tailored conditions for the on-DNA application of the Suzuki, Sonogashira, Heck, and Giese reactions. The conditions presented in this chapter have been systematically explored across different DEL designs and structurally-diverse building blocks. By providing a comprehensive insight into the practical implementation of these metal-promoted C—C bond cross-coupling reactions, this review aims at expanding and promoting the application of these transformations in DEL construction.
2.6 On-DNA Photoredox-Catalyzed Reactions
Authors: Granados A. , Molander G. A. 
Published: March 2024

AbstractThe use of visible light as the driving force to trigger chemical transformations represents an attractive tool for organic synthesis, and it has been demonstrated to be an important and well-established strategy for accessing novel bond connections in a unique way via radical intermediates. This powerful synthetic tool is under continuous development and is finding ever-increasing applications in DNA-encoded library (DEL) synthesis. Since 2018, DEL chemists have new chemical space available thanks to the implementation of visible-light-mediated methods. This chapter details the state-of-the-art of on-DNA photoredox-catalyzed transformations Specifically, this review covers simple photoredox reactions, dual-catalytic metallaphotoredox reactions, and photoredox reactions initiated by electron donor/electron-acceptor (EDA) complexes.
2.7 On-DNA Cyclization Reactions
Authors: Liu G. , Feng J. 
Published: March 2024

AbstractOn-DNA cyclization has proven to be a successful strategy, and demonstrates significant advantages for introducing structural diversity of ring systems as core structures that are present in the majority of bioactive molecules such as FDA-approved drugs, agrochemicals, and natural products. On-DNA cyclization reactions provide an attractive avenue to build highly diverse DELs based on ring systems with appropriate functionalization. In this review, synthetic strategies to access ring systems such as five-membered rings, six-membered rings, spiro rings, fused rings, and bridged rings, using on-DNA cyclization protocols, are collated.
3.2.1.2 Encoding Using Single-Stranded DNA (Iterative Splint-Ligation Procedures)
Authors: Georgiev T. , Cazzamalli S. , Neri D. , Bassi G. 
Published: March 2024

AbstractDNA-encoded libraries (DELs) are typically synthesized either in single- or double-stranded format (“ssDELs” or “dsDELs”). ssDELs may present advantages over dsDELs as they have the potential to enable a diverse set of screening methodologies such as DNA-programmed affinity labelling (DPAL), interaction-dependent PCR (IDPCR), binder trap enrichment (BTE) via water-in-oil emulsion, and DEL affinity maturation. Robust and iterative encoding methodologies are crucial in the construction of large, good quality ssDELs. This chapter presents a comprehensive overview of splint-assisted ligation procedures and their applications in library construction. Furthermore, we discuss and compare alternative ligation approaches for the synthesis of ssDELs, such as chemical ligation (via CuAAC click reaction), DNA-templated synthesis, and double- to single-strand interconversion via a photoswitchable headpiece.
2.10 Reversible Immobilization of DNA for Chemical Modification
Authors: Franzini R. M. 
Published: March 2024

AbstractReversible immobilization of DNA molecules on anion-exchange resins allows for stringent washing after on-DNA modification reactions. Furthermore, such an approach allows reactions to be performed under water-free conditions that are otherwise incompatible with DNA-conjugation. Amide-bond formation and coupling of SnAP reagents are presented as examples of reactions on reversibly immobilized oligonucleotides for DNA-encoded library synthesis.
3.2.3.2 Natural-Product-Enriched DELs
Authors: Xu H. , Ma P. , Yang G. 
Published: March 2024

AbstractNatural products are privileged compounds of natural evolution that are often rich in sp3 carbon atoms, bear multiple stereocenters, and have diverse skeletons. These features endow natural products with a broad spectrum of pharmacological activities. As a consequence, natural products play a key role in the history of medical treatment and drug discovery. The natural-product-enriched DNA-encoded library (nDEL) approach allows natural products or bioactive chemical molecules with known biological functions to be readily annotated with unique amplifiable DNA barcodes by so-called “late-stage” DNA labeling reactions. The final DNA-annotated natural products are included in a DEL, which can be packaged in a single test-tube and screened against a broad spectrum of cellular targets.
5.1 Informatic Tools, Processing, and Evaluation of DEL Selection Data
Authors: Cui W. 
Published: March 2024

AbstractDEL (DNA-encoded library) selection data is directly decoded from the readout using next-generation sequencing (NGS). For better evaluation of massive amounts of data, informatics tools making use of fundamental statistics are crucial to rule out the negatives together with identifying false-positive or false-negative signals. An understanding of the noise within the whole process, from the DEL construction to the NGS readout, will improve the accuracy and efficiency during data evaluation by scientists and, eventually, machine-learning models. Well-designed visualization tools are also helpful for efficient hit prioritization.
Digital expansionism and big tech companies: consequences in democracies of the European Union
Authors: Saura García Carlos 
Published: March 2024

AbstractBig digital companies have become key elements in economy, communication, education, and politics in 21st century societies. The neutral ideology in their digital platforms, applications, and services, as well as the exponential growth in their activities can be used by world superpowers —especially the United States and China— to implement geostrategical operations, massive social manipulation or influence democratic processes with the objective of increasing their power and dominance over other nations. The aim of this paper is to state the different strategies of digital expansionism performed by the United States and China, and, additionally, to showcase the negative consequences of these strategies on the population and democracies of the European Union. The first section of this paper will define the concepts of digital sovereignty and digital expansionism as well as their importance in 21st century geopolitics. Next, the important role that big digital companies have on digital expansionism will be analysed, and the usage of digital authoritarianism and digital instrumentarianism performed by the United States and China will be further examined. Finally, the negative consequences of the implementation of these methods in the democratic systems of the European Union will be analysed, as well as what possible solutions there might be for said consequences.
Prediction in bilingual sentence processing
Authors: Meir Natalia , Parshina Olga , Sekerina Irina A. 
Published: March 2024

Abstract
The Unified Competition Model (MacWhinney, 2012)
accounts for cross-linguistic differences in thematic role mapping. We investigated production and predictive use of accusative
case morphology in Russian-Hebrew bilingual children. We also investigated the role of production in predictive processing testing
the Prediction-by-Production Account (Pickering & Garrod, 2018)
vs. the Missing Surface Inflection Hypothesis (Prévost & White,
2000). Three groups of children aged 4–8 participated: Russian-Hebrew-speaking bilinguals, Russian-speaking and
Hebrew-speaking monolingual controls. All children participated in the accusative case production and Visual-World eye-tracking
comprehension experiments. Bilinguals were tested in both of their languages. The results of the study confirmed the predictions
of the Unified Competition Model showing typological differences in the strength of the case-marking cue and its
predictive use in sentence processing in Russian- and Hebrew-speaking controls. While Russian-speaking monolinguals relied on case
marking to predict the upcoming agent/patient, the performance of Hebrew-speaking monolingual children varied. The findings for
bilinguals showed that despite their lower production accuracy in both languages, they were either indistinguishable from
monolinguals or showed an advantage in the predictive use of case morphology. The findings support the Missing Surface
Inflection Hypothesis, which predicts a dissociation between production and comprehension.
Actions of known-answer questions in guided tours
Authors: Hosoda Yuri , Aline David 
Published: March 2024

Abstract
This study explores how guided tour interaction is achieved through certain question formats, specifically known-answer questions (KAQs), as they are deployed by guides for subsequently designing their talk to fit perceived visitor knowledge and for inviting visitor involvement in question-initiated talk. The approximately 470 minutes of video-recorded data come from guided tours in Japan, Belgium, South Korea, and Cambodia. In these tours, English was used as a common language among local guides and their foreign visitors. Analysis revealed how mobile tours are accomplished through sequences initiated by guides’ KAQs, exposing the guides’ strategic deployment of these questions and demonstrating how they subsequently utilized visitor responses to construct their talk. Comparison of the findings from the current study with those from previous research on KAQs in other institutional talk, such as educational and political settings, implies that, depending on the interactional goals, KAQs may perform diverse actions.
Les animaux aquatiques dans la fable antique et médiévale
Authors: Laïd Baptiste 
Published: March 2024

Abstraite
Poissons, dauphin, baleine, pieuvre et coquillages, mais aussi crocodiles, grenouilles, crapauds et tortues
peuplent les fables ésopiques grecques d’animaux aquatiques ou amphibies. Pourtant, ces personnages sont presque entièrement
absents dans la fable médiévale. Comment expliquer cette disparition? Muets et nettement séparés du monde des hommes et des
quadrupèdes, les poissons et les dauphins n’ont pas intéressé Phèdre qui n’en a retenu aucun dans ses fables. Avianus a traité de
quelques animaux aquatiques (poisson, crabe, tortue) ce qui a garanti leur survie à l’époque médiévale, non sans quelques
transformations qui affectent tôt l’iconographie. Romulus, de son côté, n’a hérité de Phèdre que la grenouille dans plusieurs
récits restés fameux. Cet animal, cependant, reste ambigu: rusée ou stupide? innocente ou fole? proie ou
prédatrice? À différentes périodes et dans différents styles, les fables ont tiré profit de l’ambivalence du symbolisme de cet
animal de l’entre-deux.
Sub specie animalium
Authors: Macciò Andrea 
Published: March 2024

Astratta
Dopo aver avanzato alcune ipotesi di datazione della Regale du Monde (seconda metà del secolo
XIV), l’intervento fa luce sul complesso uso simbolico degli animali nel discorso politico-sociale del componimento. Introdotta da
una trasfigurazione araldica dei regnanti di Francia e Inghilterra nel contesto contingente della guerra dei cent’anni, la visione
storico-profetica di cui consta la Regale è infatti presieduta da un universo faunistico che intende
rappresentare il microcosmo tripartito della società medioevale. In particolare, la rigenerazione del saeculum
annessa all’incipiente regno del dedicatario, Carlo V il Saggio, è messa in scena da una doppia processione e da un
conflictus che vedono protagoniste tre specie diverse di bestie e di uccelli, di cui il presente studio
intende approfondire il significato simbolico, con specifico riguardo al caso peculiarissimo del tarin (il
lucherino). L’articolo offre, infine, un’edizione e una traduzione del prologo latino che apre il testo così com’è conservato nel
codice di Cambridge (Trinity Hall Library, ms. 12, ff. 100ra–103rb).
L’écureuil, l’oie et les reliques
Authors: Radomme Thibaut 
Published: March 2024

Abstraite
L’article examine deux ‘récits de substitution lexicale,’ dans lesquels une jeune personne se voit interdire
l’usage d’un mot réputé inconvenant ou dangereux au profit d’un mot jugé convenable ou inoffensif: le fabliau
L’Esquiriel et la nouvelle Les Oies de Lipe Baldulce extraite du Decameron
de Boccace dans la traduction de Laurent de Premierfait. À partir d’une lecture croisée avec la célèbre dispute entre Raison et
l’Amant sur l’emploi du mot couille dans le Roman de la Rose, il est suggéré que ces récits
mettent en jeu l’opposition entre conventionnalisme et naturalisme linguistique et la question du caractère motivé ou arbitraire
du signe linguistique. En donnant écho à des théories linguistiques savantes, ces textes questionnent notre perception de la
frontière entre la littérature courtoise et la culture cléricale.
La mort du héros annoncée par celle de son cheval
Authors: Redondo Jordi 
Published: March 2024

Abstraite
La poésie des peuples indo-européens compte parmi ses schémas narratifs celui de la mort du cheval annonçant celle
du héros, un motif très ancien dont les traces sont répandues sur une aire géographique et linguistique concernant plusieurs
traditions aussi bien de l’Europe que de l’Asie. Du point de vue littéraire, c’est le genre épique qui détient le monopole du
thème. Notre contribution cherche d’abord à identifier les éléments les plus anciens du motif; un deuxième objectif porte sur la
distribution des différentes traditions secondaires sur la base de la distinction des innovations que l’on peut y reconnaître. Des
textes espagnols, français, grecs, iraniens, irlandais, latins, russes et serbes fourniront les données pour notre quête.
Locating the digital in literary translatorship
Authors: Zhang Wenqian , Akashi Motoko , Freeth Peter Jonathan 
Published: March 2024

Abstract
Thanks to the inclusion of sociological perspectives in the development of translator studies, the roles played by
literary translators in the movement of texts between languages and cultures, and their positions within the fields of power that
govern these processes, have become increasingly popular objects of study. However, despite the focus of sociological and
translator studies on the agency and habitus of translators in literary translation processes, little has been done to connect
this work to the ever-changing and proliferating digital contexts in which literary translation now takes place. This introductory
article therefore seeks to position existing perspectives on literary translatorship within contemporary digital contexts whilst
highlighting the increasing role of digital technology within literary translation processes, thereby emphasising the need to
include digital technologies within all forms of research on contemporary literary translatorship going forwards.
Atomistic origins of compound semiconductor synthesis with computational neuromorphic engineering
Authors: Turfanda Aykut , Hakan Gürel Hikmet , Ünlü Hilmi 
Published: March 2024

Abstract
We propose the usage of multi-element bulk materials to mimic neural dynamics instead of atomically thin materials via the modeling of group II–IV compound semiconductor growth using vacancy defects and dopants by creating and annihilating one another like a complex artificial neural network, where each atom itself is the device in analogy to crossbar memory arrays, where each node is a device. We quantify the effects of atomistic variations in the electronic structure of an alloy semiconductor using a hybrid method composed of a semiempirical tight-binding method, density functional theory, Boltzmann transport theory, and a transfer-matrix method. We find that the artificial neural network resembles the neural transmission dynamics and, by proposing resistive switching in small areas with low energy consumption, we can increase the integration density similar to the human brain.
Excitation of exchange spin waves in a magnetic insulator thin film at cryogenic temperatures
Authors: Chen Jilei , Wang Hanchen , Wang Jinlong , Sheng Lutong , Liu Tao , Liu Song , Yu Dapeng , Yu Haiming 
Published: March 2024

Abstract
Spin waves and their quanta, magnons, are promising candidates for next-generation electronic devices, due to their low-power consumption and compatibility with radio-frequency-based electronic devices. For achieving magnon-based hybrid quantum systems for quantum memory and computation, the investigation of spin-wave propagation at cryogenic temperatures is highly required. In this article, we report the excitation and detection of exchange spin waves with wavelengths of tens of nanometers in an yttrium iron garnet (YIG) thin film at cryogenic temperatures. We find that the exchange spin waves are unidirectional in all temperature ranges, owing to the chiral dynamical dipolar coupling between the spin-wave mode in the YIG and the ferromagnetic resonance mode in the cobalt nanowire. Notably, a high exchange spin-wave group velocity of 2 km s−1 at 10 K is observed. Our results are promising for the development of high-speed and energy-efficient quantum magnonic devices operating at cryogenic temperatures.