bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognosis and immunological characteristics of HDAC family in pan-cancer through integrative multi-omic analysis
Authors: Chen Changsheng , Wang Ke , Zhang Yu , Qi Yixin , Shen Chong , Zhang Zhe , Zhang Zongliang , Yang Han , Hu Hailong 
Published: March 2024

Abstract
Background
The histone deacetylase (HDAC) family plays a significant role in a variety of biological processes related to cancer, such as metabolism and cancer progression, and recognized as a target of anti-cancer drugs. Nevertheless, there has been limited systematic research available regarding HDAC family in human cancers using multi-omics approaches.

Objective
To evaluate the prognostic implications and immunological features of the HDAC family across multiple cancer types through comprehensive multi-omics analysis.

Methods
We studied the associations of HDAC activity and a variety of factors, encompassing immune checkpoint genes, the tumor microenvironment (TME), instability of microsatellites (MSI), inherited mutations, variation in copy number, tumor mutation burden (TMB), and sensitivity to drugs in a variety of cancer types. Moreover, we analyzed the link between the degree of HDAC activity and the effectiveness of immunotherapy in several cohorts, providing significant details about the possible impact of HDACs on immunotherapeutic responses. Furthermore, we explored potential signaling pathways of HDACs in bladder cancer (BC) using gene set enrichment analysis (GSEA). Immune infiltration analysis in bladder cancer was performed based on HDACs expression, copy number or somatic mutations. Furthermore, the Human Protein Atlas (HPA) dataset has been used to validate the expression of the HDACs protein in BC.

Results
The HDACs expression exhibits significant heterogeneity across different cancer types and is significantly correlated with patient prognosis, clinical traits, mutations, TME, TMB, MSI, immune checkpoint genes, and objective responses in immunotherapy. The drug sensitivity of cancers was found to be correlated with the gene expression of specific HDAC familial members. In BC, GSEA demonstrates enrichment of multiple immune-related functions and pathways; moreover, there are significant associations between genomic variations in HDACs and the degree of typical immunological cell recruitment. Furthermore, findings from differential expression analysis in BC are validated by protein expression analysis obtained from the HPA database.

Conclusions
These findings reveal the significance of HDAC family in survival prognosis and treatment guidance of human cancers, and some of them have the potential to be used as immunotherapy biomarkers.
Assessment of left atrial function by two-dimensional speckle tracking echocardiography in patients with metabolic-associated fatty liver disease
Authors: El Sharkawy Sara I. , Aboulenien Yousra , Elnagar Basma , Elkhalawany Walaa , Badawi Rehab 
Published: March 2024

Abstract
Background
Metabolic-associated fatty liver disease (MAFLD) and cardiovascular diseases have mutual risk factors that contribute to pathogenic processes, increasing mortality and morbidity. This study aimed to evaluate variations in left ventricular (LV) structure and diastolic function among different subtypes and severity degrees of MAFLD patients, allowing early identification, intervention, and prevention of severe cardiac outcomes in high-risk populations.

Results
The cross-sectional study included 142 MAFLD patients and 142 non-MAFLD participants as a control group. All participants underwent abdominal ultrasound, transient elastography, transthoracic echocardiography, tissue Doppler, and strain imaging. The results showed a significant impairment in the diastolic left ventricular function, as assessed with tissue Doppler, and the left atrial (LA) function, as evaluated with strain imaging, in the MAFLD group. Additionally, the left atrial stiffness was significantly higher in the MAFLD group.

Conclusion
The use of strain imaging facilitated the detection of subtle impairments of the left atrial reservoir, contraction, conduit function, and left ventricular diastolic function in MAFLD patients.
The Planar Cell Polarity Protein Fat1 in Sertoli Cell Function
Authors: Bu Tiao , Wang Lingling , Wu Xiaolong , Gao Sheng , Li Xinyao , Yun Damin , Yang Xiwen , Li Linxi , Cheng Chuen Yan , Sun Fei 
Published: March 2024

Abstract
Fat (FAT atypical cadherin) and Dchs (Dachsous cadherin–related protein) in adjacent Sertoli:Sertoli, Sertoli:spermatid, and spermatid:spermatid interfaces create an important intercellular bridge whose adhesive function is in turn supported by Fjx1, a nonreceptor Ser/Thr protein kinase. This concept is derived from earlier studies of Drosophila, which has been confirmed in this and earlier reports as well. Herein, we use the approach of knockdown of Fat1 by RNAi using primary cultures of Sertoli cells that mimicked the blood–testis barrier (BTB) in vivo, and a series of coherent experiments including functional assays to monitor the Sertoli cell tight junction (TJ) permeability barrier and a functional in vitro TJ integrity assay to assess the role of Fat1 in the testis. It was shown that planar cell polarity (PCP) protein Fat1 affected Sertoli cell function through its modulation of actin and microtubule cytoskeletal function, altering their polymerization activity through the Fat1/Fjx1 complex. Furthermore, Fat1 is intimately associated with β-catenin and α-N-catenin, as well as with Prickle 1 of the Vangl1/Prickle 1 complex, another PCP core protein to support intercellular interactions to confer PCP. In summary, these findings support the notion that the Fat:Dchs and the Vangl2:Fzd PCP intercellular bridges are tightly associated with basal ES/TJ structural proteins to stabilize PCP function at the Sertoli:Sertoli, Sertoli:spermatid, and spermatid:spermatid interface to sustain spermatogenesis.
Risks, Patterns, and Preventive Measures in the Analysis of Snowboarding Injuries
Authors: Kotowicz Zuzanna , Pabiś Jakub , Podgórski Piotr , Górecka Sandra , Olszański Miłosz , Bogusz Aleksander , Kwiatkowski Oskar , Kołodziej Anna , Król Anita 
Published: March 2024

Introduction
Snowboarding is an activity that appears to be gaining popularity among people who are interested in winter sports. The dynamic evolution of the method of snowboarding comes with it the risk of injuries, the consequences of which can be catastrophic. As a result of the fact that this sporting activity is distinguished by a diverse riding technique and calls for the use of specialized equipment, the mechanism of damage is also distinct from that which is known in, for instance, skiing. In addition, comparable to skiing, snowboarding has a sub-discipline that is linked with the execution of tricks and jumps. In a disproportionate manner, this raises the probability of an accident occurring. Wrist, shoulder, and ankle joints are among the most often injured structures in the body. Trauma to the brain and spine are remarkably uncommon, nonetheless, they are the ones that have the most serious repercussions. It is imperative that special attention be made to the avoidance of these incidents, which is why both medical professionals and proprietors of ski resorts stress the need of people wearing helmets and other protective gear, such as wrist guards. It is anticipated that the implementation of these techniques will lead to a decrease in the occurrence of the most common and serious forms of injuries, as well as a reduction in the strain placed on the organization that provides medical care.
Aim of the study
This review aims to characterize the most common injuries acquired during snowboarding, analyze their mechanism and to show methods of prevention.
Material and method
This article presents the current state of knowledge on snowboarding injuries, their mechanisms and prevention in various scientific articles. Publications describing injuries that occur while snowboarding were reviewed using the PubMed platform. The search included the keywords 'snowboard', 'injuries', 'fracture', ‘trauma’.
CuI Promoted Efficient Synthesis and Antimicrobial Activity of Substituted 8,8-Dimethyl-5-phenyl-2-(pyrazin-2-yl)-5,7,8,9-tetrahydro-6H-[1,3,4]thiadiazolo[2,3-b]quinazolin-6-one
Authors: Khadgamala N. Sridevi , Rao V. Narasinga , Apparao K. , Durgarao B.V , Diwakar B.S. , Rao N. Krishna 
Published: March 2024

In present study, an efficient synthesis of substituted 5,7,8,9-tetrahydro-6H-[1,3,4]thiadiazolo[2,3-b]quinazolin-6-one compounds promoted by CuI as catalyst was carried out. These derivatives were obtained from 1,3,4-thiadiazol-2-amine, dimedone and substituted aromatic aldehyde in presence of CuI in ethanol as solvent at 70 ºC. Initially, 1,3,4-thiadiazol-2-amine was synthesized from pyrazine-3- carboxylic acid reacted with thiosemicarbazide in the presence of 50% H2SO4 in acetonitrile at 70 ºC. All the newly obtained derivatives were evaluated by the spectroscopic techniques such as 1H NMR, 13C NMR and LCMS and structural determination of titled analogous were analyzed by elemental analysis. The antibacterial activities of the newly synthesized compounds were also screened.
Density, Speed of Sound and Derived Properties of Binary Mixtures Propiophenone + Butoxyethanol at T = (303.15, 308.15, 313.15 and 318.15) K
Authors: Durga Bhavani M. , Kavitha Ch. , Narendra K. , Bhavani P. 
Published: March 2024

The current study reports the experimental density (ρ) and sound speed (u) values for binary mixes of liquids propiophenone + 2-butoxyethanol at atmospheric pressure (0.1 MPa) and T = (303.15, 308.15, 313.15 and 318.15) K for the full spectrum of composition. densities and sound speed measurements from experiments have been used to estimate excess isentropic compressibility (κsE), excess molar volume (VEm), excess molar isentropic compressibility (KEs,m), excess isobaric thermal expansivity (αEp) and excess sound speed (uE). The Redlich-Kister polynomials were used to correlate excess parameters. Excess partial molar volume quantities (VEm,1 and VEm,2) at infinite dilution and their limiting values (V0Em,1 and V0Em,2) have been analytically determined using Redlich-Kister polynomials from the experimental density data. The results have been analyzed in light of strength and interactions among molecular entities scope and extent prevalent in these mixtures.
Computer Vision Syndrome in Medical Students - Knowledge, Attitude, Practice (KAP) Study
Authors: Aishwarya Patil  , Niharika Shetty  
Published: March 2024

BACKGROUND
The use of computers and visual display devices has become an integral part of our lives. As a result, a large number of people around the world are suffering from various ocular symptoms, including dry eyes, ocular strain, eye irritation, and ocular redness. All of these ocular symptoms are commonly called computer vision syndrome. The purpose of this study was to determine the prevalence, community knowledge, and pathophysiology of computer vision syndrome, as well as the factors associated with and preventing CVS.
METHODS
A cross-sectional study was conducted among 150 medical students and the data was collected through a structured, web-based, and self-administered questionnaire, which was pre tested and pre-validated.
RESULTS
In this study, 38.7% had a pre-existing knowledge on CVS. 94.67% of the respondents reported having mild to moderate symptoms of dry eyes. It is found that people use screens mostly for social media and entertainment. Long hours spent on the small screen led to sleep disturbances in about 56% of the students. According to our survey, 54% of the students used spectacles and frequent change of spectacles was present. About 40% of the students used topical eye drops prescribed by ophthalmologist.
CONCLUSIONS
The increasing use of digital screen and prevalence of computer vision syndrome. When combined with increased screen time, dry eyes and good quality sleep can lead to serious health problems like learning difficulties and operative errors, which may pose a challenge in the modern era. Right education, attitude and practice regarding CVS are required to all the medical students due to their increased dependency on digital devices. Proper practice and preventive measures are necessary for a doctor /surgeon for health benefit of the patients and community.
THE EFFECTIVENESS OF INTERACTIVE MULTIMEDIA-BASED LEARNING METHODS TO INCREASE THE MOTIVATION OF ELEMENTARY SCHOOL TEACHERS IN THE JSIT KULONPROGO ENVIRONMENT
Authors: Lidyasari Aprilia Tina , Rokhman Muhamad Nur , Nugroho Alifi Nur Prasetia , Anggito Albi 
Published: March 2024

Teachers' motivation in developing multimedia in primary-secondary school teachers who are members of the Kulonprogo integrated Islamic school network is still low. The purpose of this study is to see if there is a significant effect on teacher motivation after providing interactive multimedia training to teachers. Multimedia training includes providing material about interactive multimedia, making multimedia by teachers, mentoring, demonstrations and producing interactive multimedia products from elementary junior high schools. The research method used is a pre-experiment design involving 25 primary-secondary school teachers who are members of the Kulonprogo integrated Islamic school network. The sampling technique used is purposive sampling and uses the Wilcoxon test in data analysis. Activities will be carried out using offline and online methods using a theoretical and practical approach. Theoretical material and practical assistance are carried out in the Kapanewon Kulonprogo area. The implementation of activities will be reflected through an evaluation of the participants' understanding of the material, seen from the performance, work results, program implementation evaluation questionnaire. Training is carried out offline and online. Offline training was held at the Yogyakarta State University Hall, Wates Campus offline and online through the zoomeeting application. The results of the implementation of this training based on the pre-post questionnaire obtained an increase in pre-post results from an average of 58.2 to an average of 69.52. While the results of data processing using SPSS obtained Sig Value. <0.05, this shows that there is a significant effect on teacher motivation before and after the provision of training in making interactive multimedia for teachers. The conclusion of the research is that there is a positive influence on teacher motivation before and after the provision of interactive multimedia training to elementary and junior high school teachers who are members of an integrated Islamic school network in Kulonprogo Regency, Yogyakarta Special Region.
IMPLEMENTATION OF SCHOOL LITERACY MOVEMENT TO ENHANCE READING INTEREST OF STUDENTS IN SOUTH SUMATRA
Authors: Hamzah Amir , Tasya Wilda , Rusdi Amir , Krisetyaningsih Krisetyaningsih , Tastin Tastin 
Published: March 2024

This research aimed to evaluate the implementation of the School Literacy Movement (SLM) program, identifying the supporting and hindering factors to enhance the reading interest of students in some Elementary Schools (ES) such as ES of Yayasan IBA in Palembang, Elementary Schools of 01 Indralaya in Ogan Ilir Regency, and Elementary Schools of 3 Kayu Agung in Ogan Komering Ilir Regency. The analysis used a qualitative method with a descriptive and multi-site approach using interview guidelines, questionnaires, and observation sheets as instruments. The results showed that the implementation of the SLM program in ES of 01 Indralaya and ES of 3 Kayu Agung, effectively fostered the reading interest of fourth-grade students according to the indicators published by the Ministry of Education and Culture, including the stages of habituation, development, and learning. The supporting factors of the program that were identified included Libraries, Reading Corners, Bulletin Boards, Reading Gardens and School Literacy Carts, Identity Boards Literacy Trees, Media Utilization, School Gardens, Public Engagement, SLM Team, School Gardens, Training and Study Tours, Reading Materials, and Reading Campaign Posters. Furthermore, the hindering factors were reluctance to study, a lack of reading habits, inability to read proficiently, and insufficient support for library management by qualified librarians.
IMPLEMENTASI KEBIJAKAN PENURUNAN STUNTING DI KABUPATEN SOLOK
Authors: Gusdiva Nelvia , Koeswara Hendri , Putera Roni Ekha 
Published: March 2024

Isu kebijakan pencegahan dan penurunan stunting merupakan suatu permasalahan yang menarik perhatian, mengingat kebijakan yang dikeluarkan oleh pemerintah belum mampu untuk menekan permasalahan angka stunting yang ada. Kebijakan penurunan stunting yang dikeluarkan pemerintah diharapkan mampu mengatasi permasalahan stunting di Indonesia, namun pada nyatanya angka stunting masih tinggi atau bisa dikatakan tidak mengalami penurunan secara stabil dalam sepuluh tahun terakhir ini. Kabupaten Solok merupakan salah satu wilayah prioritas pemerintah pusat dalam penanganan stunting sejak tahun 2019. Penelitian ini bertujuan untuk mendeskripsikan dan menganalisis bagaimana implementasi kebijakan penurunan stunting di Kabupaten Solok. Penelitian ini dilakukan dengan menggunakan metode deskriptif kualitatif dengan menggunakan teori implementasi kebijakan yang dikemukakan oleh Van Meter dan Van Horn. Hasil penelitian menunjukkan bahwa implementasi kebijakan penurunan stunting di Kabupaten Solok menunjukkan masih terdapat beberapa kendala dalam pelaksanaannya, standar kebijakan masih mengacu kepada regulasi kebijakan yang lama dan belum direvisi berdasarkan kebijakan stunting terbaru. Kurang tersedianya sumber daya manusia dan anggaran yang tersedia serta pengaruh dari lingkungan sosial, ekonomi, dan politik yang mempengaruhi pelaksanaan kebijakan penurunan stunting di Kabupaten Solok
KLASTERISASI PROVINSI DI INDONESIA MENURUT KARAKTERISTIK KETENAGAKERJAAN TAHUN 2019 MENGGUNAKAN METODE FUZZY C-MEANS CLUSTERING
Authors: Nasida Farakh Khoirotun , Pasha Afiqi Ilman , Oktaviani Oki , Syahri Nur Alfi , Andriatno Aan , Nooraeni Rani 
Published: March 2024

Ketenagakerjaan merupakan bidang yang vital dalam pembangunan ekonomi maupun pembangunan manusia. Dewasa ini, problematika terkait ketenagakerjaan semakin kompleks dan menjadi tantangan dunia. Sustainable Development Goals menyoroti secara khusus peningkatan kualitas ketenagakerjaan, tertuang dalam tujuan kelima, yang secara lebih spesifik menggarisbawahi kelayakan pekerjaan. Sampai tahun 2030, dunia menargetkan kelayakan pekerjaan penuh yang diimbangi dengan menurunnya tingkat pengangguran. Pengangguran merupakan suatu fenomena yang banyak mendapatkan sorotan dan merupakan isu strategis dalam pemerintahan suatu negara. Di Indonesia, Tingkat Pengangguran Terbuka telah mencapai level yang setara dengan pengangguran global. Meskipun demikian, masih terjadi ketimpangan antarprovinsi. Penerapan program dan kebijakan yang sesuai dengan karakteristik ketenagakerjaan provinsi diperlukan untuk mengatasi ketimpangan serta mewujudkan kelayakan pekerjaan secara beriringan. Penelitian ini menggunakan metode Fuzzy C-Means Clustering untuk mengelompokkan 34 provinsi di Indonesia ke dalam klaster-klaster menurut karakteristik ketenagakerjaan. Analisis dilakukan dengan memperhatikan dua aspek, yaitu kesempatan kerja dan kelayakan pekerjaan. Penelitian ini berhasil mengklasifikasikan 34 provinsi ke dalam dua klaster. Klaster pertama beranggotakan provinsi-provinsi dengan tingkat kesempatan kerja yang rendah, namun kelayakan pekerjaannya sudah baik. Sedangkan klaster kedua memiliki karakteristik kesempatan kerja yang tinggi, namun belum diimbangi dengan kelayakan pekerjaan yang baik. Terhadap kedua klaster yang terbentuk, pemerintah diharapkan dapat memberikan perlakuan atau menerapkan kebijakan yang sesuai dengan karakteristik yang dimiliki.
In the Eye of the Storm: The Disrupted Career Paths of Young People in the Wake of COVID-19
Authors: Issehnane Sabina , Moulin Léonard 
Published: March 2024

Abstract
Using a survey representative of individuals who left the educational system in France at any level in 2017, we examine the impact of the COVID-19 pandemic on young people’s probability of being employed between the start of lockdown in March 2020 and July 2020. We find that the COVID-19 pandemic had a strong impact on youth employment. Our results show that young people’s probability of being employed decreased by as much as 3 % during the lockdown period relative to the pre-pandemic baseline. This impact is smaller than that observed in other countries, probably due to the significant measures implemented in France. Our heterogeneity analyses indicate that the impact of the COVID-19 pandemic on young people’s labor market integration varied with the type of employment contract, area of study, and, to a lesser extent, having a working-class parent, a foreign-born parent, or residing in a rural area.
The Decision Behaviour Evaluation of Interrelationships among Personality, Transformational Leadership, Leadership Self-Efficacy, and Commitment for E-Commerce Administrative Managers
Authors: Shih-Kun Liu Weng 
Published: March 2024

Abstract
Due to the impact of the Coronavirus disease 2019 (COVID-19) epidemic isolation, the E-commerce market encountered great impact and changes. Faced with such a transformed situation, E-Commerce administrative managers usually have different individual personalities and transformational leadership to enhance leadership self-efficacy and organizational commitment. The purpose of this study is to investigate the interrelationships among the personality, transformational leadership, leadership self-efficacy, and commitment of E-Commerce administrative managers. The research population is randomly selected from E-Commerce administrative managers who are responsible for E-Commerce administrative affairs. Based on a sample of 408 participants, the Confirmatory Factor Analysis (CFA) is applied to examine the construct validity. Then, the Structured Equation Modelling (SEM) method is used to estimate a series of interrelated dependent relationships and perform a comprehensive model. The research results show that a leader with Big Five personality traits has a positive influence on transformational leadership and leadership self-efficacy. An E-Commerce administrative manager with transformational leadership behaviours has a positive influence on leadership self-efficacy. In addition, an E-Commerce administrative manager with leadership self-efficacy has a positive influence on commitment. The research results contribute to a better evaluation model of E-Commerce administrative manager’s leadership by applying their personalities and transformational leadership to enhance leadership self-efficacy and increase the level of organizational commitment.