bluuebunny/crossref_metadata_2025_split huggingface dataset:
Digital Detox Among Adolescents at Summer Camp
Authors: Reed Janet M. , Gies Ashley 
Published: February 2025

ABSTRACT:
Computer and internet addiction as well as compulsive social media use have become significant problems for adolescents. Residential summer camps offer the opportunity for campers to experience a digital detox in a supportive setting where digital devices are not available. A retrospective chart analysis of health clinic logs for campers ages 8-18 at an 8-day residential Christian athletic summer camp in 2023 asked: What percentage of summer camp health clinic visits were due to symptoms consistent with technology withdrawal, and did health clinic utilization differ based on gender? Visits for sleep (6%) and anxiety (2%) symptoms had the highest likelihood of being consistent with symptoms of technology withdrawal; female campers had more clinic visits than males. Nursing interventions for camp health concerns and the relevance of biblical spiritual care for adolescent campers are discussed.
Evaluation of Control Arm Quality in Recent Radiation Oncology Randomized Clinical Trials
Authors: Ekpunobi Ifeanyi O. , Flores Laura E. , Jagsi Reshma , McClelland Shearwood 
Published: February 2025

Background:
For randomized controlled trials (RCTs) to provide the highest levels of evidence for clinical practice, it is ethically imperative for patients assigned to the control arm to receive standard-of-care treatment. Oncologic medical trials investigating new systemic agents have demonstrated a high proportion of RCTs with inadequate control arms. It is unknown whether this finding is prevalent in oncologic trials investigating radiation therapy (RT) for cancer.

Methods:
ClinicalTrials.gov was queried for registered clinical trials investigating RT in patients with cancer from 2013 to 2023. Each control arm was analyzed, with the standard of care determined by National Comprehensive Cancer Center Network (NCCN) guidelines at the time of initial trial posting.

Results:
Five hundred eight interventional studies with results registered were included, of which 12 met inclusion criteria for final analysis. Two trials each investigated RT usage in central nervous system, prostate, head and neck, and breast disease sites, and 1 each for lung, hepatobiliary, rectal, and bone disease sites. Most trials were industry-funded (83%); 75% of studies took place in the United States. Hundred percent of trials had an adequate control arm per the corresponding NCCN guidelines.

Conclusion:
All recently completed oncologic RCTs investigating RT for cancer involved an adequate control arm. This finding contrasts with the high proportion of inadequate control arms in medical oncology trials. These findings suggest that adequate control arm treatments are feasible to achieve in trial design, emphasizing both the need for continued focus on improving the quality of ethical oncologic research trials and a possible subspecialty that may serve as an exemplar.
The Freestyle Multiperforator Island Flap: Beyond the Keystone Flap
Authors: Gómez Oswaldo J. , Espinel Pinzón Daniel Alejandro , Duque David F. , Moreno Harold D. , Beltrán Pachón Paloma 
Published: February 2025

Background:
This study aimed to introduce freestyle multiperforator island flaps as a technical advancement beyond keystone perforator flaps. These flaps represent a fully free-design approach, supplied by multiperforators in small subcutaneous pedicles randomly located, allowing for customized designs tailored to anatomical regions of diverse complexity.

Methods:
We present a retrospective cohort study of 150 patients with coverage defects, without distinction of anatomical location or age, treated between 2012 and 2021. The study assessed the clinical presentation, flap characteristics, additional procedures, and postoperative outcomes. We used the chi-square test to assess the relationship between pedicle area size and the incidence of partial or complete necrosis.

Results:
We performed 211 flaps on 184 defects, with a mean follow-up of 8.7 months. Tumors (30.4%) and trauma (23.3%) were the most common etiologies. Most flaps were performed on the head and neck (31%) and lower limbs (30.4%). The mean pedicle area was 33%, and the flap-to-defect size ratio was between 1:1 and 3:1 in 82% of cases. Complications occurred in 29.8% of the flaps, with only 8.1% needing surgical reintervention. The most common occurrences were dehiscence (18.5%), partial necrosis (9%), and total necrosis (1.9%). The pedicle area of the flap did not demonstrate a statistically significant relationship with the necrosis outcome (P = 0.813; 95% confidence interval, 0.17–0.926).

Conclusions:
Freestyle multiperforator island flaps are a safe and versatile tool with low necrosis rates, excellent aesthetic results, and unmatched cost-effectiveness.
The impact of integrated care on clinical outcomes in patients with alcohol-associated liver disease: Early outcomes from a multidisciplinary clinic
Authors: Sengupta Shreya , Anand Akhil , Yang Qijun , Reagan Meghan , Husted Mariah , Minnick Austin , Nagy Laura E. , Dasarathy Srinivasan , Sims Omar T. , Mellinger Jessica L. 
Published: February 2025

Background:
We analyzed early outcomes regarding the impact of our integrated alcohol-associated liver disease (ALD) clinic on patients with ALD and alcohol use.

Methods:
We conducted a retrospective study of patients with ALD who were evaluated in our integrated clinic from May 1, 2022, to December 31, 2023. Primary outcomes included differences in baseline clinical/demographic data between patients who accepted versus declined an appointment and changes in the severity of ALD, alcohol consumption, functional status, hospital utilization, and remission in alcohol use disorder for evaluated patients.

Results:
Patients who declined appointments (n=66) had higher median no-show rates (15.0 [8.0,30.0] vs. 8.5 [3.25,15.0], p<0.001), social vulnerability index (0.53 [0.26,0.79] vs. 0.38 [0.17,0.63], p=0.033), and proportions of cirrhosis (78.8% vs. 59.8%, p=0.017) versus evaluated patients. Comparison of baseline to first follow-up visit for evaluated patients (n=102) demonstrated significant reductions in median AST (59.5 [41.75, 89] vs. 44.5 [33.5, 56.25], p<0.001), alanine-aminotransferase (33.5 [20,45.25] vs. 26.5 [18.75,33.0], p=0.017), total bilirubin (1.6 [0.7,3.3] vs. 1 [0.5,1.9], p=0.001), phosphatidylethanol (263 [35, 784] vs. 0 [0, 163], p<0.001), MELD-3.0 and Sodium scores for patients with alcohol-associated hepatitis and cirrhosis (16 [11, 18.75] vs. 12 [9, 14], p<0.001), 14 [9.25, 17.75] vs. 11 [8.5, 14], p<0.001), and Child-Turcotte-Pugh scores for patients with cirrhosis (9 [6, 10.5] vs. 7 [6, 9], p<0.001). The proportion of patients with active-severe alcohol use disorder significantly decreased (85.2% vs. 51.9%, p<0.001). Additionally, patients had significant reductions in emergency department utilization (incidence rate ratio of 0.64 emergency department visits/month (p=0.002) and 0.71 hospital admissions/month (p=0.025). However, after considering the false discovery rate, the reduction in hospitalization admissions/month was not statistically significant (False Discovery Rate adjusted p=0.056).

Conclusions:
Our integrated approach led to reductions in liver injury, degree of liver decompensation, alcohol use, and ED utilization, and remission in AUD in a population of both non-transplant ALD and post-transplant patients.
TTF-1 and p40 co-expressing non-small cell lung cancer with ERBB2 and TP53 gene mutations: A case report and review of the literature
Authors: Sun Jiachun , Shi Haolin , Sun Bo , Wei Tingting , Su Jingxiang , Liu Hongyan , Wang Dengkui , Li Xinyang 
Published: February 2025

Rationale:
Non-small cell lung cancer (NSCLC) that co-expresses thyroid transcription factor-1 (TTF-1) and p40 represents a distinct subtype of lung cancer. This case report details a 53-year-old male patient with NSCLC exhibiting co-expression of TTF-1 and p40, highlighting the need for further investigation into this unique presentation of NSCLC.

Patient concerns:
A 53-year-old male, nonsmoker, presented to our hospital in November 2023 with complaints of cough, expectoration, chest pain, and dyspnea.

Diagnoses:
Computed tomography scans revealed perihilar lesions in the upper lobe of the right lung with distal obstructive pneumonia, invasion into adjacent mediastinal structures, multiple pulmonary metastases, possible mediastinal and right hilar lymph node metastases, pleural effusion, and a slightly thickened pleura in the right lung, along with multiple metastatic lesions in the liver. Immunohistochemical analysis showed positive staining for CK (AE1/AE3), TTF-1, and p40, while CK56, CD68, CD45 (LCA), D2-40, and Ki-67 (50%+) were negative, leading to the diagnosis of lung adenocarcinoma. Second-generation sequencing identified mutations in ERBB2 (EXON20.p.Y772-A775dup) and TP53 (EXON5.c.404G-Tp.C135F).

Interventions:
The patient underwent 6 cycles of chemotherapy with a regimen consisting of bevacizumab, pemetrexed, and carboplatin.

Outcomes:
Posttreatment evaluations on December 28, 2023, and February 25, 2024, indicated stable disease. The patient is currently on a maintenance chemotherapy regimen of bevacizumab and pemetrexed, and his condition is stable.

Lessons:
The co-expression of TTF-1 and p40 in NSCLC may define a novel subtype of lung cancer. Further research is imperative to elucidate its characteristics, molecular mechanisms, and to establish its morphological features and therapeutic strategies.
Arthroscopic-assisted versus fluoroscopic-assisted open reduction and internal fixation for distal radius fracture: A systematic review and meta-analysis
Authors: Chen Keyi , Yang Shun , Cheng Yabo , Xiang Wang 
Published: February 2025

Background:
In recent years, there has been an increasing trend in the use of wrist arthroscopy to facilitate the treatment of distal radius fractures using open reduction and internal fixation (ORIF). However, there is no consensus on its superiority despite some previous studies comparing these 2 surgical techniques. Hence, this study sought to conduct a systematic comparison of the effectiveness and safety of arthroscopic-assisted open reduction and internal fixation (AAORIF) and fluoroscopic-assisted open reduction and internal fixation (FAORIF) in the management of distal radius fractures.

Methods:
A comprehensive search was conducted in multiple databases to acquire all literature published until January 31st, 2024, comparing AAORIF versus FAORIF for the treatment of distal radius fracture, without any language or publication status restrictions. The Cochrane Collaboration’s RevMan 5.4 software was used to perform a meta-analysis.

Results:
Five randomized controlled trials (169 patients in the AAORIF group and 171 patients in the FAORIF group) suggested that patients with distal radius fracture treated with AAORIF had better disability of arm, shoulder, and hand scores, visual analog scale score, and wrist extension than those treated with FAORIF. However, no significant differences were observed in terms of wrist flexion, pronation, supination, operative time, and complication outcomes between the 2 groups.

Conclusion:
Despite the lack of significant differences in wrist flexion, pronation, supination, operative time, and complication outcomes between the 2 groups, the AAORIF group had more obvious advantages in terms of disability of arm, shoulder, and hand scores, visual analog scale score, and wrist extension based on the above results. We believe that treatment of distal radius fracture with AAORIF may be an optimal option compared with FAORIF. Absolutely, and additional high-quality studies with larger sample sizes are necessary to establish stronger evidence regarding this subject.
Clinical and genetic analysis of a female child with duplications at 7p22.3p22.1 and Xp22.31p21.1: A case report
Authors: Bu Chenchen , Zha Xi Quzhen , Deng Ying 
Published: February 2025

Rationale:
Intellectual disability (ID) is a neurodevelopmental disorder with diverse etiologies. Chromosomal duplications are recognized as a common cause of ID, with manifestations typically milder than those associated with deletions. Duplications involving the short arm of chromosome 7 or the X chromosome have been linked to ID. Limited data exist on duplications at 7p22.1p22.3 and Xp22.31p21.1, leaving their clinical significance largely unexplored. This case report aims to expand the phenotype and genetics spectrum of 7p22 duplication syndrome and X-linked ID. Special attention should be paid to closely monitoring the pubertal progression of such patients.

Patient concerns:
A 9-year-10-month-old female was admitted to our hospital due to distinctive dysmorphic features and ID.

Diagnoses:
Upon examination, features of craniofacial dysmorphism were observed, including micrognathia, a prominent lower lip, a thin upper lip, a flat nasal bridge, and hypertelorism. The child’s pubertal development is progressing extremely rapidly; at under 10 years old, the breasts have already advanced to Tanner Stage 4. Her height was within the median range, but her bone age was advanced (12.1 years). Her full-scale intelligence quotient, assessed using the Wechsler Intelligence Scale for Children: 4th edition, was 41.

Interventions:
Whole exome sequencing identified a de novo duplication spanning overlapping regions at Xp21-22 and 7p22. This duplication encompasses several genes implicated in ID, including Duchenne muscular dystrophy, Aristaless-related homeobox, interleukin-1 receptor accessory protein like 1, adaptor-related protein complex 1 subunit sigma 2, and cyclin-dependent kinase-like 5.

Outcomes:
A novel duplication in the Xp and 7p of a Chinese female child diagnosed with ID and dysmorphic features has been studied by whole exome sequencing analysis. The novel duplications were a large duplication located in the 7p22.1 to p22.3 region, spanning 12.07 Mb, and a large duplication located in the Xp22.31 to p21.1 region, spanning 24.7 Mb.

Lessons:
Our study underscores the importance of comprehensive clinical and genetic evaluation in individuals with duplication on the X chromosome and the terminal region of chromosome 7’s short arm. We highlight the need for monitoring these patients for growth and sexual development issues. Our findings also suggest that chromosomal duplication can lead to severe clinical manifestations, emphasizing the critical role of genetic assessment in managing such cases.
Cellular Proliferation Imaging With 18F-FMAU PET/CT as Adjunct to mpMRI in Image-Guided Biopsy of Suspected Prostate Cancer
Authors: Jadvar Hossein , Chen Kai , Mohamed Passant , Jadvar Donya S. , Abreu Andre Luis 
Published: February 2025

Purpose:
We evaluated the potential diagnostic utility of PET with the cellular proliferation biomarker, 2′-deoxyl-2′-[18F]fluoro-5-methyl-1-beta-D-arabinofuranosyluracil (18F-FMAU), as an adjunct to multiparametric MRI (mpMRI), in localization of sites for image-guided biopsy in men with suspected prostate cancer.

Patients and Materials:
Seventeen men with clinically suspected prostate cancer underwent standard mpMRI and investigational PET/CT with 18F-FMAU.

Results:
Tissue samples obtained from 22 image-guided biopsies were examined histologically. There were 11 benign, 6 ISUP grade 1, and 5 ISUP grade 2 tumors. The sensitivity for detection of ISUP 1 and ISUP 2 prostate cancer was 16.7% and 100% for mpMRI, and 50% and 60% for 18F-FMAU PET/CT, respectively.

Conclusions:

18F-FMAU PET/CT may be a useful adjunct to mpMRI in image-guided prostate biopsy.
Magnetic properties of the zigzag ladder compound
SrTb2O4
Authors: Orlandi F. , Ciomaga Hatnean M. , Mayoh D. A. , Tidey J. P. , Riberolles S. X. M. , Balakrishnan G. , Manuel P. , Khalyavin D. D. , Walker H. C. , Le M. D. , Ouladdiaf B. , Wildes A. R. , Qureshi N. , Petrenko O. A. 
Published: February 2025

We report on the properties of SrTb2O4, a frustrated zigzag ladder antiferromagnet, studied by single crystal neutron diffraction (with polarized neutrons in zero field and unpolarized neutrons in an applied magnetic field), as well as by neutron spectroscopy on a polycrystalline sample. The neutron scattering results are supported by single-crystal magnetization and heat capacity measurements. In zero field, neutron diffraction data show no transition to a magnetically ordered state down to the lowest experimentally available temperature of 35 mK, and the material remains magnetically disordered down to this temperature. Polarized neutron diffraction measurements reveal the presence of a diffuse scattering signal suggesting only very weak spin-spin correlations in the ground state. For H∥c (the easy magnetization direction), we followed the magnetization process using neutron diffraction measurements and observed the appearance of field-induced magnetic Bragg peaks with integer h and k indices in the (hk0) scattering plane. No magnetic peaks with a nonzero propagation vector were detected. The observed in-field data fit well to a simple two-sublattice model with magnetic moments aligned along the field direction but being significantly different in magnitude for the two inequivalent Tb3+ sites in the unit cell. Overall, the collected data point to a nonmagnetic ground state in SrTb2O4 despite the presence of strong interactions.

Published by the American Physical Society
2025
Dark dimension and the grand unification of forces
Authors: Heckman Jonathan J. , Vafa Cumrun , Weigand Timo , Xu Fengjun 
Published: February 2025

The dark dimension scenario, predicting one extra mesoscopic dimension in the micron range, has emerged by applying various swampland principles to the dark energy. In this note we find that realizing the grand unification of gauge forces is highly constraining in this context. Without actually constructing any grand unified theory (GUT) models, we argue that the mere assumption of grand unification of forces in this scenario, together with the experimental bounds on massive replicas of the Standard Model gauge bosons, predicts an upper bound for the GUT scale, MGUT≲1016  GeV. Combined with the experimental bound on the proton lifetime, this predicts that the X gauge boson mediating proton decay is a 5D solitonic string of Planckian tension stretched across a length scale L∼(1–10  TeV)−1 ending on gauge branes of the same diameter ∼L. This leads to a mass of MX∼1015–1016  GeV. In particular assuming grand unification in the dark dimension scenario results in a tower of Kaluza-Klein excitations of Standard Model gauge bosons on the gauge branes in the 1–10 TeV range. This suggests that the diameter/separation L of the gauge branes correlates with both the weak scale ∼1/L near a TeV the GUT scale ∼M52L at 1016  GeV.

Published by the American Physical Society
2025
Tracing financial inclusion pathway to sustainable development: the criticality of population growth and energy intensity using a machine learning approach
Authors: Iorember Paul Terhemba , Hounkanrin Dian Oluwatobi , Diyoke Kenneth , Tang Chor Foon 
Published: February 2025

PurposeDespite the criticality of financial inclusion, population growth and energy intensity in shaping production and consumption, economic and environmental sustainability, less attention has been directed to their collective and integrating role as pathways to sustainable development. This study therefore examines the critical link between financial inclusion and sustainable development in Nigeria, taking into account the role of population growth and energy intensity.Design/methodology/approachThe study employs the Kernelized regularized least squares (KRLS) machine learning approach and Granger causality test to investigate the pathways of financial inclusion, population growth and energy intensity on sustainable development.FindingsFinancial inclusion path to sustainable development is not statistically significant. This is because the potential of financial inclusion are eclipsed by broader economic problems Population growth and energy intensity have significant dampening effects on sustainable development. These results have broad ramifications for environmental sustainability and macroeconomic strategies to Nigeria’s quest for achieving sustainable development.Practical implicationsPolicies such as improvement of financial literacy and development of responsible financial behavior among the underserved populations can enhance the role of financial inclusion in sustainable development. Similarly, investment in education and human capital development, and adoption of renewable energy technologies can mitigate the effects of population growth and energy intensity.Originality/valueThe present study focuses on the pathway of financial inclusion to sustainable development, taking into account key variables of population growth and energy intensity.
The effect of psychosocial working conditions on work engagement and burnout in European communication industry
Authors: Ferreira Pedro , Gomes Sofia , Lopes João M. 
Published: February 2025

PurposeResponding to the lack of research on work engagement and burnout of professionals in the communication industries, this work’s main objective is to evaluate the effect of psychosocial working conditions (meaningful work, trust and recognition) on work engagement and burnout. Additionally, the mediating role of employee voice is tested.Design/methodology/approachThe study takes a quantitative approach. A sample of 3,386 European workers in the communication industries was taken from the 2021 European Working Conditions Survey. The measurement of the main concepts is based on the variables available in the database above. The hypotheses were tested using the partial least squares method.FindingsThe results reveal that all psychosocial working conditions (meaningful work, trust and recognition) contribute to promoting work engagement and reducing burnout. Furthermore, employee voice is a mediator of the relationship between psychosocial working conditions, work engagement and burnout, although the presence of employee voice reduces the robustness of those relationships.Practical implicationsThese results present relevant practical implications for managing workers in the communication industries, namely some clues to promote positive employee outcomes through the management of psychosocial working conditions.Originality/valueThis study examines the underexplored topic of work engagement and burnout in professionals in the communication industries as well as the relevance of psychological working conditions and employee voice to those outcomes. Furthermore, this study provides insightful information that is particularly useful to the European setting, where cultural aspects and working conditions may vary greatly from those in other parts of the world.