bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surviving the Storm: The Role of Poly‐ and Depolyploidization in Tissues and Tumors
Authors: Zhao Yucui , He Sijia , Zhao Minghui , Huang Qian 
Published: April 2024

AbstractPolyploidization and depolyploidization are critical processes in the normal development and tissue homeostasis of diploid organisms. Recent investigations have revealed that polyaneuploid cancer cells (PACCs) exploit this ploidy variation as a survival strategy against anticancer treatment and for the repopulation of tumors. Unscheduled polyploidization and chromosomal instability in PACCs enhance malignancy and treatment resistance. However, their inability to undergo mitosis causes catastrophic cellular death in most PACCs. Adaptive ploid reversal mechanisms, such as multipolar mitosis, centrosome clustering, meiosis‐like division, and amitosis, counteract this lethal outcome and drive cancer relapse. The purpose of this work is to focus on PACCs induced by cytotoxic therapy, highlighting the latest discoveries in ploidy dynamics in physiological and pathological contexts. Specifically, by emphasizing the role of “poly‐depolyploidization” in tumor progression, the aim is to identify novel therapeutic targets or paradigms for combating diseases associated with aberrant ploidies.
Loss of OVOL2 in Triple‐Negative Breast Cancer Promotes Fatty Acid Oxidation Fueling Stemness Characteristics
Authors: Lu Ruipeng , Hong Jingjing , Fu Tong , Zhu Yu , Tong Ruiqi , Ai Di , Wang Shuai , Huang Qingsong , Chen Ceshi , Zhang Zhiming , Zhang Rui , Guo Huiling , Li Boan 
Published: April 2024

AbstractTriple‐negative breast cancer (TNBC), the most aggressive subtype of breast cancer, has a poor prognosis and lacks effective treatment strategies. Here, the study discovered that TNBC shows a decreased expression of epithelial transcription factor ovo‐like 2 (OVOL2). The loss of OVOL2 promotes fatty acid oxidation (FAO), providing additional energy and NADPH to sustain stemness characteristics, including sphere‐forming capacity and tumor initiation. Mechanistically, OVOL2 not only suppressed STAT3 phosphorylation by directly inhibiting JAK transcription but also recruited histone deacetylase 1 (HDAC1) to STAT3, thereby reducing the transcriptional activation of downstream genes carnitine palmitoyltransferase1 (CPT1A and CPT1B). PyVT‐Ovol2 knockout mice develop a higher number of primary breast tumors with accelerated growth and increased lung‐metastases. Furthermore, treatment with FAO inhibitors effectively reduces stemness characteristics of tumor cells, breast tumor initiation, and metastasis, especially in OVOL2‐deficient breast tumors. The findings suggest that targeting JAK/STAT3 pathway and FAO is a promising therapeutic strategy for OVOL2‐deficient TNBC.
Dynamic Reconfiguration and Local Polarization of NiFe‐Layered Double Hydroxide‐Bi2MoO6−x Heterojunction for Enhancing Piezo‐Photocatalytic Nitrogen Oxidation to Nitric Acid
Authors: Deng Xiaoxu , Chen Peng , Cui Ruirui , Gong Xingyong , Wu Yubo , Wang Xu , Deng Chaoyong 
Published: April 2024

AbstractConstructing heterojunctions with vacancies has garnered substantial attention in the field of piezo‐photocatalysis. However, the presence of interfacial vacancies can serve as charge‐trapping sites, leading to the localization of electrons and hindering interfacial charge transfer. Herein, dual oxygen vacancies in the NiFe‐layered double hydroxide and Bi2MoO6−x induced interfacial bonds have been designed for the piezo‐photocatalytic N2 oxidation to NO3−. Fortunately, it achieves sensational nitric acid production rates (7.23 mg g−1 h−1) in the absence of cocatalysts and sacrificial agents, which is 6.03 times of pure Bi2MoO6 that under ultrasound and light illumination. Theoretical and experimental results indicate that interfacial bonds act as “charge bridge” and “strain center” to break the carrier local effect and negative effects with piezocatalysis and photocatalysis for promoting exciton dissociation and charge transfer. Moreover, the strong electronic interaction of the interfacial bond induces internal reconstruction under ultrasound for promoting the local polarization and adsorption of N2, which accelerates the fracture of the N≡N bonds and reduces the activation energy of the reaction. The research not only establishes a novel approach for optimizing the combined effects of piezo‐catalysis and photocatalysis, but also achieves equilibrium between the synergistic impacts of vacancies and heterojunctions.
Secondary Structure in Enzyme‐Inspired Polymer Catalysts Impacts Water Oxidation Efficiency
Authors: Sedenho Graziela C. , Nascimento Steffane Q. , Zamani Marjon , Crespilho Frank N. , Furst Ariel L. 
Published: April 2024

AbstractProtein structure plays an essential role on their stability, functionality, and catalytic activity. In this work, the interplay between the β‐sheet structure and its catalytic implications to the design of enzyme‐inspired materials is investigated. Here, inspiration is drawn from the active sites and β‐sheet rich structure of the highly efficient multicopper oxidase (MCO) to engineer a bio‐inspired electrocatalyst for water oxidation utilizing the abundant metal, copper. Copper ions are coordinated to poly‐histidine (polyCuHis), as they are in MCO active sites. The resultant polyCuHis material effectively promotes water oxidation with low overpotentials (0.15 V) in alkaline systems. This activity is due to the 3D structure of the poly‐histidine backbone. By increasing the prevalence of β‐sheet structure and decreasing the random coil nature of the polyCuHis secondary structures, this study is able to modulates the electrocatalytic activity of this material is modulated, shifting it toward water oxidation. These results highlight the crucial role of the local environment at catalytic sites for efficient, energy‐relevant transformations. Moreover, this work highlights the importance of conformational structure in the design of scaffolds for high‐performance electrocatalysts.
Self‐Sacrificial Template Synthesis of Fe‐N‐C Catalysts with Dense Active Sites Deposited on A Porous Carbon Network for High Performance in PEMFC
Authors: Jiao Li , Arman Tanvir Alam , Hwang Sooyeon , Fonseca Javier , Okolie Norbert , Shaaban Ehab , Li Gonghu , Liu Ershuai , Pasaogullari Ugur , Babu Siddharth Komini , Mukerjee Sanjeev , Spendelow Jacob Schatz , Cullen David A. , Jaouen Frédéric , Jia Qingying 
Published: April 2024

AbstractIron‐nitrogen‐carbon (Fe‐N‐C) single‐atom catalysts are promising sustainable alternatives to the costly and scarce platinum (Pt) to catalyze the oxygen reduction reactions (ORR) at the cathode of proton exchange membrane fuel cells (PEMFCs). However, Fe‐N‐C cathodes for PEMFC are made thicker than Pt/C ones, in order to compensate for the lower intrinsic ORR activity and site density of Fe‐N‐C materials. The thick electrodes are bound with mass transport issues that limit their performance at high current densities, especially in H2/air PEMFCs. Practical Fe‐N‐C electrodes must combine high intrinsic ORR activity, high site density, and fast mass transport. Herein, it has achieved an improved combination of these properties with a Fe‐N‐C catalyst prepared via a two‐step synthesis approach, constructing first a porous zinc‐nitrogen‐carbon (Zn‐N‐C) substrate, followed by transmetallating Zn by Fe via chemical vapor deposition. A cathode comprising this Fe‐N‐C catalyst has exhibited a maximum power density of 0.53 W cm−2 in H2/air PEMFC at 80 °C. The improved power density is associated with the hierarchical porosity of the Zn‐N‐C substrate of this work, which is achieved by epitaxial growth of ZIF‐8 onto g‐C3N4, leading to a micro‐mesoporous substrate.
Raisins in a Hydrogen Pie: Ultrastable Cesium and Rubidium Polyhydrides
Authors: Zhou Di , Semenok Dmitrii , Galasso Michele , Alabarse Frederico Gil , Sannikov Denis , Troyan Ivan A. , Nakamoto Yuki , Shimizu Katsuya , Oganov Artem R. 
Published: April 2024

AbstractA new method for synthesis of metal polyhydrides via high‐pressure thermal decomposition of corresponding amidoboranes in diamond anvil cells is proposed. Within this approach, molecular semiconducting cesium (P4/nmm‐CsH7, P1‐CsH15+x) and rubidium (RbH9‐x) polyhydrides with a very high hydrogen content reaching 93 at.% are synthesized. Preservation of CsH7 at near ambient conditions, confirmed both experimentally and theoretically, represents a significant advance in the stabilization of hydrogen‐rich compounds. In addition, two crystalline modifications of RbH9‐x with pseudohexagonal and pseudotetragonal structures identified by synchrotron X‐ray diffraction, and Raman measurements are synthesized. Both phases are stable at 8–10 GPa. This is an unprecedentedly low stabilization pressure for polyhydrides. These discoveries open up possibilities for modifying existing hydrogen storage materials to increase their efficiency.
Superdense Lithium Deposition via Mixed Ionic/Electronic Conductive Interfaces Implanted In Vivo/Vitro for Stable Lithium Metal Batteries
Authors: Ma Changjing , Jiang Wenlong , Duan Qiange , Ning De , Wang Man , Wang Jun , Chen Bingan , Jiang Haobo , Yang Chunlei , Wu Wei 
Published: April 2024

AbstractLithium metal batteries specialize in energy density, while the immoderate dendrite growth and solid electrolyte interphase (SEI) proliferation have been impeding their practical application. The key is the regulation of Li+ diffusion/nucleation behaviors toward a dense deposition. Herein, Li9Al4/Li3N energized mixed ionic/electronic conductive (MIEC) interfaces are pre‐implanted in both the surface and bulk of the lithium metal anode. Such MIEC interfaces are activated from the in situ conversion and nano‐alloying reactions between AlN and metallic Li and are uniformly dispersed via facile mechanical kneading. In vitro, MIEC interfaces participate in the formation of an inorganic‐enriched SEI that balances ionic transport, electron blocking, and mechanical strength to guarantee homogeneous ion fluxes and structural integrity. In vivo, a unique nanorod‐array architecture enables a released internal stress and rapid diffusion kinetics, affording a dense and large granular plating manner. As a result, the symmetric cell delivers a striking cumulative capacity of >120000 mAh cm−2 at 20 mA cm−2@20 mAh cm−2 with a prolonged lifespan of over 6000 h. The improved machinability also enables a scalable fabrication of ultrathin foil to achieve a stable high‐areal‐capacity full cell for 320 cycles with enhanced energy density characteristics both gravimetrically and volumetrically.
Adding mirror clauses within the European Green Deal: Hype or hope?
Authors: Gohin Alexandre , Matthews Alan 
Published: April 2024

AbstractThe proposed reductions in farm input uses foreseen in the European Green Deal may penalize European farm production while increasing environmental leakages to foreign countries where production may expand. These expected impacts have led to calls for a more restrictive trade policy based on mirror clauses. This paper considers as a case study a potential ban on glyphosate in vegetable and fruits production. We develop an original computable general equilibrium model with endogenous adoption of new European production standards by foreign producers on currently latent markets. We find in our case study that adding mirror clauses to the Green Deal marginally improves European farm income and the global environmental footprint of food. We find that foreign producers as a whole can gain from these clauses and not lose as in a standard analysis. European households support these clauses by paying higher food bills while consuming vegetables and fruits produced without glyphosate.
Integration effects of soil amendments and cover crops on dryland no‐till corn
Authors: Adeli A. , Brooks J. P. , Miles D. M. , Hu J. , Huang Y. , Bheemanahalli R. , Jenkins J. N. 
Published: April 2024

AbstractA field study was carried out at the Mississippi Agricultural and Forestry Experiment Station near Pontotoc to evaluate the synergistic impacts of broiler litter (BL) and inorganic fertilizer nitrogen (N) with flue gas desulfurization (FGD) gypsum and lignite in the presence of winter cover crops (WCCs) on dryland no‐till corn (Zea mays L.) in Falkner silt loam soil. The experimental design was a split‐plot randomized complete block design with three replications. The main plots were WCC and winter fallow (WF), and the subplots were fertilization treatments. Fertilization treatments included BL, inorganic fertilizer N, FGD gypsum and lignite with BL, FGD gypsum and lignite with inorganic fertilizer N, and an unfertilized control. BL, FGD gypsum, and lignite were applied at the rates of 13.4, 3.4, and 3.4 Mg ha−1, respectively. Inorganic fertilizer N was applied to corn at 168 kg N ha−1. BL increased soil carbon (C), soil infiltration, and resulted in higher corn grain yield compared to both inorganic fertilizer N and unfertilized control in 2020 and 2022. Averaged across fertilization treatments, WCC improved soil moisture, soil C, and soil infiltration by 16%, 19%, and 25% at the 0‐ to 15‐cm depth, respectively, and increased corn grain yield by 25% as compared to WF in 2022. Cover crops boosted corn grain yield during drier years. The combination of FGD gypsum and lignite with BL increased corn grain yield by 15% in 2020 and 13% in 2022 compared to BL alone. This approach can be considered to promote the sustainability of agroecosystems.
Ionic liquid for simultaneous desulfurization and dehydration of flue gas: Data‐driven thermodynamics and mechanisms
Authors: Zhao Fei , Liu Qinghua , Song Minghao , Kang Hongwei , Liu Shuqing , Cheng Yongqiang , Lei Zhigang 
Published: April 2024

AbstractA process of simultaneous desulfurization and dehydration of flue gas with ionic liquid was explored. The selection of ionic liquid was completed based on COSMO‐SAC model. Random forest (RF) and one‐dimensional convolutional neural network were trained for the prediction of CO2 and SO2 solubility. A feature selection method is designed to remove verbose descriptors. The feature importance was analyzed by SHAP analysis. Quantum chemistry calculation and molecular dynamics (MD) simulation were used to investigate the type and position of intermolecular forces. The results show that the R2 coefficients of the two prediction models for CO2 and SO2 test sets reach 0.981 and 0.983. [EMIM][SCN] was selected as the optimal solvent, and the interaction with SO2 is mainly electrostatic and orbital interaction, while the interaction with H2O is strong hydrogen bond.
Direct biosynthesis of massive intracellular CdSe QDS across entire S. oneidensisMR‐1 for photosynthesis of hydrogen
Authors: Yi Xiaofeng , Liu Shurui , Li Yixin , Luo Qingliu , Li Qingbiao , Xia Dong , Wang Yuanpeng 
Published: April 2024

AbstractIntracellular biosynthesis of massive quantum dots inside bacteria remains a grand challenge, with such a technology unsatisfactory due to the high toxicity of metal ions to the cell and the ultralow yield of quantum dots. Herein, a gshA‐overexpressed Shewanella oneidensis MR‐1 strain was constructed with the ability to effectively detoxify SeO32− species, rendering the formation of substantial CdSe quantum dots across the entire cell entity. As such, the photoexcited electrons generated from the entire bacterium entity led to promoted electron mobilization efficiency and photoelectron‐involved cellular energy metabolism, along with the direct contact between quantum dots and hydrogenase to significantly reduce electron transfer resistance. Consequently, the constructed system disclosed distinctive performance for artificial H2 photosynthesis, with an appreciable H2 production rate of 32.4 μM⋅h−1. This work opens up new avenues for the direct biosynthesis of intracellular quantum dots across the entire microbes.
Trabecular bone variation in the gorilla calcaneus
Authors: Harper Christine M. , Patel Biren A. 
Published: April 2024

AbstractObjectivesCalcaneal external shape differs among nonhuman primates relative to locomotion. Such relationships between whole‐bone calcaneal trabecular structure and locomotion, however, have yet to be studied. Here we analyze calcaneal trabecular architecture in Gorilla gorilla gorilla, Gorilla beringei beringei, and G. b. graueri to investigate general trends and fine‐grained differences among gorilla taxa relative to locomotion.Materials and methodsCalcanei were micro‐CT scanned. A three‐dimensional geometric morphometric sliding semilandmark analysis was carried out and the final landmark configurations used to position 156 volumes of interest. Trabecular thickness (Tb.Th), trabecular spacing (Tb.Sp), and bone volume fraction (BV/TV) were calculated using the BoneJ plugin for ImageJ and MATLAB. Non‐parametric MANOVAs were run to test for significant differences among taxa in parameter raw values and z‐scores. Parameter distributions were visualized using color maps and summarized using principal components analysis.ResultsThere are no significant differences in raw BV/TV or Tb.Th among gorillas, however G. b. beringei significantly differs in z‐scores for both parameters (p = <0.0271). All three taxa exhibit relatively lower BV/TV and Tb.Th in the posterior half of the calcaneus. This gradation is exacerbated in G. b. beringei. G. b. graueri significantly differs from other taxa in Tb.Sp z‐scores (p < 0.001) indicating a different spacing distribution.DiscussionRelatively higher Tb.Th and BV/TV in the anterior calcaneus among gorillas likely reflects higher forces associated with body mass (transmitted through the subtalar joint) relative to forces transferred through the posterior calcaneus. The different Tb.Sp pattern in G. b. graueri may reflect proposed differences in foot positioning during locomotion.
White matter hyperintensities and the surrounding normal appearing white matter are associated with water channel disruption in the oldest old
Authors: Silbert Lisa C. , Roese Natalie E. , Krajbich Victoria , Hurworth Justin , Lahna David , Schwartz Daniel L. , Dodge Hiroko H. , Woltjer Randall L. 
Published: April 2024

AbstractINTRODUCTIONAge‐related magnetic resonance imaging (MRI) T2 white matter hyperintensities (WMHs) are common and associated with neurological decline. We investigated the histopathological underpinnings of MRI WMH and surrounding normal appearing white matter (NAWM), with a focus on astroglial phenotypes.METHODSBrain samples from 51 oldest old Oregon Alzheimer's Disease Research Center participants who came to autopsy underwent post mortem (PM) 7 tesla MRI with targeted histopathological sampling of WMHs and NAWM. Stained slides were digitized and quantified. Mixed‐effects models determined differences in molecular characteristics between WMHs and the NAWM and across NAWM.RESULTSPM MRI‐targeted WMHs are characterized by demyelination, microglial activation, and prominent astrocytic alterations, including disrupted aquaporin (AQP) expression. Similar changes occur within the surrounding NAWM in a pattern of decreasing severity with increased distance from WMHs.DISCUSSIONDecreased AQP expression within WMH and proximal NAWM suggest an overwhelmed system wherein water homeostasis is no longer maintained, contributing to WM damage in older individuals.Highlights
Post mortem magnetic resonance imaging (MRI) was used to characterize the pathology of white matter hyperintensities (WMHs) and surrounding normal appearing white matter (NAWM).
Stained immunohistochemical (IHC) slides from targeted WMH and NAWM samples were digitized and quantified.
WMHs and NAWM were associated with inflammation, demyelination, and gliosis.
WMHs and NAWM astrocytic changes included decreased AQP1 and AQP4 expression.
Abnormal NAWM pathology diminished in severity with increasing distance from WMH.
Optomechanical Coupling Optimization in Engineered Nanocavities
Authors: Edelstein S. , Gomis‐Bresco J. , Arregui G. , Koval P. , Lanzillotti‐Kimura N. D. , Torrent D. , Sotomayor‐Torres C. M. , García P. D. 
Published: April 2024

AbstractIn optomechanics, the interaction between light and matter is enhanced by engineering cavities where the electromagnetic field and the mechanical displacement are confined simultaneously within the same volume. This leads to a wide range of interesting phenomena, such as optomechanically induced transparency and the cooling of macroscopic objects to their lowest possible motion state. In this manuscript, the focus is on designed optomechanical cavities exploiting heterostructures in air‐slot photonic‐crystal waveguides, incorporating different hole shapes and dimensions to engineer and control their optomechanical properties. The aim is to maximize the optical quality factor of the optical cavity, while ensuring optical mode volumes below the diffraction limit. These optimized optical modes interact with in‐plane motional degrees of freedom of the structures achieving high optomechanical coupling rates, thus opening up the possibility of mechanical amplification, nonlinear dynamics and chaos through the optomechanical back‐action.
Perfluorooxosulfate Salts as SOF4‐Gas‐Free Precursors to Multidimensional SuFEx Electrophiles
Authors: Zogu Armir , Ullah Karim , Spanopoulos Stefanos , Ismalaj Ermal , De Borggraeve Wim M. , Demaerel Joachim 
Published: April 2024

AbstractSulfur(VI) Fluoride Exchange (SuFEx) chemistry stands as a well‐established method for swiftly constructing complex molecules in a modular fashion. An especially promising segment of this toolbox is reserved for multidimensional SuFEx hubs: three or more substituents pluggable into a singular SVI centre to make ‘beyond‐linear’ clicked constructions. Sulfurimidoyl difluorides (RNSOF2) stand out as the prime example of this, however their preparation from the scarcely available thionyl tetrafluoride (SOF4) limits this chemistry to only a few laboratories with access to this gas. In this work, we identify silver pentafluorooxosulfate (AgOSF5) as a viable SuFEx hub with reactivity equal to SOF4. The AgF2‐mediated oxidation of SOCl2 gives rise to the hexacoordinate AgOSF5 adduct, which in contact with primary amines produces the sulfurimidoyl fluorides in high yields. In addition, we have found this workflow to be fully extendable to the trifluoromethyl homologue, AgOSF4CF3, and we propose the use of AgOSF4X salts as a general route to azasulfur SuFEx electrophiles from commercial starting materials.
SilE−R und SilE−S – DABB‐Proteine mit der Fähigkeit zur enantiospezifischen Hydrolyse von Organosilylethern
Authors: Pick Lisa M. , Oehme Viviane , Hartmann Julia , Wenzlaff Jessica , Tang Qingyun , Grogan Gideon , Ansorge‐Schumacher Marion B. 
Published: April 2024

AbstractSilylether spielen in der synthetisch‐organischen Chemie als Schutzgruppen eine wichtige Rolle. Einen Schlüsselfaktor für ihre Verwendung bildet die selektive Spaltung. Erstmals stellen wir hier zwei Enzyme – SilE−R und SilE−S – vor, die in der Lage sind, Silylether zu hydrolysieren. Sie gehören zur Familie der Stress‐Response‐A/B‐Barrel‐Domäne‐beinhaltenden Proteine (DABB) und spalten die Si−O‐Bindung mit entgegengesetzter Enantiopräferenz. Akzeptiert werden Silylether mit aromatischen, cyclischen oder aliphatischen Alkoholanteilen und, je nach Alkohol, Silylfunktionen bis hin zu TBDMS. Aus der Röntgenkristallstruktur von SilE−R, die mit einer Auflösung von 1,98 Å bestimmt wurde, und Mutationsstudien konnte ein aktives Zentrum mit zwei Histidinresten, H8 und H79, abgeleitet werden. Die Reste scheinen synergistisch als Nukleophil und Brønsted‐Base zu wirken, wie es in bekannten Mechanismen der enzymatischen Hydrolyse bisher nicht beschrieben wurde. Die natürliche Funktion von SilE−R und SilE−S ist noch unbekannt, für synthetische Anwendungen ist aber großes Potenzial dieser „Silyletherasen“ zu erwarten.