bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship between Microvascular Resistance and Perfusion in Patients with Reperfused Acute Myocardial Infarction
Authors: SEZER MURAT , UMMAN BERRIN , OKCULAR IREM , NISANCI YILMAZ , UMMAN SABAHATTIN 
Published: August 2007

Despite its prognostic importance, accurate assessment of microvascular perfusion in patients with ST elevation acute myocardial infarction (STEMI) is difficult. As a new tool, the index of microvascular resistance (IMR) measurement provides us a new opportunity for interrogating microvascular condition after STEMI. In this study, we measured IMR in infarct‐related artery (IRA) and explored its relation with other indices which have been suggested to evaluate microvascular perfusion in patients with reperfused STEMI.
Methods: Forty‐two patients with STEMI treated successfully with primary percutaneous coronary intervention (pPCI) were prospectively included. After 48 hours following pPCI, patients were recatheterized and IMR, coronary flow reserve (CFR), systolic and mean coronary wedge pressures (CWPs and CWPm) pressure‐derived collateral flow index (CFIp) were measured in IRA by using intracoronary pressure‐temperature sensor tipped guide wire. Myocardial blush grade was assessed from the second angiogram. Coronary flow velocity pattern (diastolic deceleration time: DDT) was examined with transthoracic echocardiography 48 hours after pPCI. Percentage of ST‐segment recovery was calculated from surface ECG (STR%).
Results: IMR well correlated with CWPs (r = 0.70, P < 0.001), CWPm (r = 0.59, P < 0.001), CFIp (r = 0.65, P < 0.001), CFR (r =−0.50, P = 0.001), and DDT (r =−0.59, P = 0.001). Correlations of IMR to non/semiinvasive indices like myocardial blush grades (MBG) (r =−0.42, P = 0.007) and STR (r =−0.37, P = 0.024) are somewhat weaker.
Conclusion: Given its simplicity of measurement, independence from the presence of an epicardial stenosis, and good correlation with all measures of microvascular obstruction used in this study, IMR may prove to be a valuable modality for evaluating the microcirculation.
CT Coronary Angiography Predicts the Outcome of Percutaneous Coronary Intervention of Chronic Total Occlusion
Authors: SOON KEAN H. , COX NICHOLAS , WONG AARON , CHAITOWITZ IVAN , MACGREGOR LACHLAN , SANTOS PETER T. , SELVANAYAGAM JOSEPH B. , FAROUQUE H.M. OMAR , RAMETTA SALVATORE , BELL KEVIN W. , LIM YEAN L. 
Published: August 2007

Background: The success rate of percutaneous coronary intervention (PCI) of chronic total occlusions (CTO) is relatively low. Further evaluation of CTO lesion with CT coronary angiography (CT‐CA) may help to better select patients that would benefit from percutaneous revascularization. We aimed to test the possible association between failed PCI and transluminal calcification of CTO as assessed by CT‐CA.
Methods: Patients with CTO awaiting PCI were scanned with a 16‐slice CT. A cardiologist and a radiologist assessed transluminal calcification of CTO lesions on CT images while an interventional cardiologist at a core laboratory assessed conventional variables of invasive fluoroscopic coronary angiography (FCA) associated with failed PCI of CTO. The significance of CT and FCA variables in association with failed PCI were analyzed.
Results: In a cohort of 39 patients with 43 CTO lesions, 24 lesions were successfully revascularized. Transluminal calcification ≥50% as assessed on CT‐CA was strongly associated with failed PCI (odds ratio [OR] of PCI success = 0.10, 95% confidence interval [CI]: 0.02–0.47, P = 0.003). Blunt stump as seen on FCA was also associated with failed PCI (OR of PCI success = 0.24, 95% CI: 0.07–0.86, P = 0.029). There was no significant evidence to support that the duration of CTO, presence of side branch and bridging collaterals, and the absence of microchannels as assessed with FCA were associated with failed PCI. On multivariate analysis, transluminal calcification ≥50% on CT‐CA was the only significant predictor of failed PCI.
Conclusions: Heavy transluminal calcification as assessed with CT‐CA is an independent predictor of failed PCI of CTO. CT‐CA may have a role in the work‐up of CTO patients prior to PCI.
Does Carbofilm Coating Affect In‐Stent Intimal Proliferation? A Randomized Trial Comparing Rx Multi‐Link Penta and Tecnic Carbostent™ Stents: SIROCCO Trial
Authors: CARRIÉ DIDIER , LEFEVRE THIERRY , CHERRADI RHIZLAN , DUMAS PIERRE , ELBAZ MEYER , FINET GÉRARD , PUEL JACQUES , MORICE MARIE CLAUDE 
Published: August 2007

Objectives:

To compare the volume of in‐stent neointimal proliferation, assessed by intravascular ultrasound (IVUS), at 6‐month follow‐up after implantation of a coronary Carbofilm™‐coated stent (Tecnic Carbostent™, Sorin Biomedica Cardio, Saluggia, Italy) versus a conventional 316 L stent (Rx Multi‐Link Penta, Abbott Laboratories, Abbott Park, IL).
Background:

Many trials suggest that stent characteristics and coating could be important determinants of restenosis.
Methods:

From October 2004 to May 2005, 63 patients were randomized to Tecnic (T, n = 30) or Penta (P, n = 33). The primary end‐point was in‐stent volume of neointimal hyperplasia (NIH) measured by IVUS at 6 months. The secondary end‐points included binary restenosis, minimal luminal diameter (MLD), target lesion revascularization, and major adverse cardiac events.
Results:

There were no significant differences between T and P as to mean age, male gender, clinical status, complexity of the lesion, lesion length, reference vessel diameter before percutaneous coronary intervention (PCI), MLD pre‐PCI, and stent‐to‐artery ratio. However, MLD poststenting was greater in P group than T group (2.81 ± 0.45 mm vs. 2.49 ± 0.33 mm, P < 0.002). At 6 months, angiographic late lumen loss (0.61 ± 0.51 mm vs. 0.92 ± 0.61 mm, P < 0.043), in‐stent obstruction (25.86 ± 16.48% vs. 38.33 ± 19.56%, P = 0.021), and in‐stent late loss volume (31.62 ± 29.75 mm3 vs. 57.28 ± 37.16 mm3, P = 0.016) were significantly lower in T group than in P group.
Conclusion:

Penta stent appears to offer a better deployment and a larger MLD post‐PCI than Carbofilm‐coated stent. However, a thicker NIH was observed on Penta stent at 6‐month follow‐up, when compared to Tecnic.
Suicidal risks among 2826 Sardinian major affective disorder patients
Authors: Tondo L. , Lepri B. , Baldessarini R. J. 
Published: August 2007

Objective:  We estimated risks of suicidal behaviors in 2826 mood‐disorder patients evaluated and followed in a Sardinian mood disorders research center over the past 30 years.Method:  We determined rates of suicidal ideation, attempts, and suicides, with associated risk factors, in men and women with DSM‐IV bipolar I (BP‐I; n = 529), BP‐II; (n = 314), or major depressive disorders (MDD; n = 1983), at risk for an average of 11 years of illness.Results:  Observed rates (% of patients/year) of suicide ranked: BP‐II (0.16) ≥ BP‐I (0.14) > MDD (0.05); attempts: BP‐I (1.52) > BP‐II (0.82) > MDD (0.48); ideation: BP‐II (42.7) > MDD (33.8) > BP‐I (22.7). The ratio of attempts/suicides (lethality index) ranked: BP‐II (5.12) < MDD (9.60) ≤ BP‐I (10.8). Male/female risk‐ratios were greater for suicide than attempts or ideation. One‐third of all reported acts occurred within the first year of illness, and earliest among MDD patients. Factors associated independently with suicidal acts included BP diagnosis, hospitalizations/person, and early illness‐onset; factors associated with suicidal ideation were having an affective temperament, BP‐II diagnosis, and higher suicidality‐corrected depression score at intake.Conclusion:  Suicidal behaviors were more prevalent among BPD than MDD out‐patients.
Anxiety symptoms in schizophrenia spectrum disorders: associations with social function, positive and negative symptoms, hope and trauma history
Authors: Lysaker P. H. , Salyers M. P. 
Published: August 2007

Objective:  Anxiety is commonly observed in schizophrenia, but its relationship with other features of illness is unclear.Method:  We examined correlations between measures of anxiety, positive and negative symptoms, hope, psychosocial function and trauma history among 128 participants with schizophrenia or schizoaffective disorder. Cluster analyses were conducted to determine whether we could detect a subgroup with severe anxiety.Results:  Higher levels of anxiety were associated with greater hallucinations, withdrawal, depression, hopelessness, better insight and poorer function. Cluster analyses produced three groups according to anxiety level: subclinical anxiety (n = 37), moderate anxiety (n = 55) and severe anxiety (n = 36). anova revealed that the severe anxiety group had more severe hallucinations, poorer psychosocial function and less hope than either of the other two groups. Self‐report of sexual trauma predicted higher levels of anxiety overall.Conclusion:  A subgroup of persons with severe anxiety may be identifiable in schizophrenia with a unique clinical profile.
Twenty‐year trends in emotional and behavioral problems in Dutch children in a changing society
Authors: Tick N. T. , Van Der Ende J. , Verhulst F. C. 
Published: August 2007

Objective: Research into changes in the prevalence of children’s psychiatric diagnoses has indicated an increase in recent decades. However, methodological problems may have influenced results. This study compared children’s emotional and behavioral problem levels across three population samples from different time points across 20 years, assessed with identical methodologies.Method: We compared Child Behavior Checklists and Teacher’s Report Forms across three population samples of 6‐ to 16‐year olds, assessed in 1983, 1993, and 2003.Results: We found evidence for small increases in the mean population levels of parent‐reported problems, and in the percentages of children with serious problems. These changes concerned mostly internalizing problems. Teacher reports showed less changes. Decreases in scores were found on several areas of competence. Changes were the strongest between 1993 and 2003.Conclusion: We found evidence for small increases in Dutch children’s problems. Further developments must be monitored, as this trend may continue and have serious societal consequences.
Corneille's Trols Discours: A Reader's Guide
Authors: Carlin Claire 
Published: August 2007

Unlike the majority of his contemporaries who wrote treatises on drama theory, Pierre Corneille claimed not to believe in the necessity of a moral message in the theatre. This study suggests that Corneille did indeed have a didactic goal, but a rather original one: he forces the spectator or reader to judge the heroes of his plays in terms of their service to society.While Corneille obliges the audience to take on the responsibility of defining the hero, he also places himself and the audience in a similar relationship of performance and judgment in Les Trois Discours. The writer is a virtuoso performer who enumerates the ways in which a play might teach a moral lesson, only to undermine the didactic value of the reward of virtue and punishment of vice and of the moralistic conception of catharsis. Corneille dissects and then reconstructs such fundamental notions as vraisemblance and bienseance, showing how his colleagues’treatment of them is rigid and limiting. Corneille is the poet of flexibility: with supple arguments, he manipulates his audience into not simply reaction, but active analysis of the characters’behaviour, thereby engendering conflicting interpretations of his work, which continues to inspire controversy today.
Diderot, Falconet and the Theology of Art the Testimony of the Correspondence
Authors: Ages Arnold 
Published: August 2007

The debate over Diderot's views about religion no longer causes dispute. By his middle years Diderot was no longer vacillating between agnosticism and atheism; he had opted for a strictly materialistic, atheistic view of the cosmos.It is somewhat ironical therefore, that in his correspondence with the famous sculptor, Falconet, over the question of posterity and artistic fame, Diderot introduces a level of discourse which resonates with theological images and vocabulary.In the argument with Falconet, who denigrated the idea of posthumous reward, Diderot constructs a secular eschatology, a kind of mirror image of the Judeo‐Christian vision which he uses in order to explain and justify artistic creativity.Diderot's eschatology is, of course, terrestrial and is based on an optimism which is pre‐nuclear. His emphasis on the imperishable nature of artistic genius, however, is uncannily close to theological surmise about the immortality of the soul.Perhaps the strongest argument in Diderot's arsenal is the view that the future rectifies the errors of the past. The great artist who suffers for his métier will be rehabilitated by the opinion of posterity. This idea dovetails with the bliss which the faithful will experience in paradise, despite the sufferings they endured on earth.
Thomas Bernhards Korrektur. Ein Untergang
Authors: Jeutter Ralf 
Published: August 2007

In diesem Artikel zu Thomas Bernhards 1975 erschienen Roman Korrektur sollen zwei methodische Anzatze zusammengefuhrt wer‐den, die in der Thomas Bernhard Forschung in Konflikt miteinan‐der stehen: Es wird behauptet, daß der Roman einerseits dem poetologischen Kernsatz Bernhards von der Kunstlichkeit alien Geschehens in seinen Biichern gerecht wird, indem er extrem selbstreferntiell ist, d.h. der Roman problematisiert auf vielen Ebenen den spezifischen Schreibprozess Thomas Bernhards. Auf der anderen Seite erlaubt es die interpretatorische Limitation auf diesen Aspekt nicht, das eigentliche Thema des Romans, namlich den Untergang Roithamers, zu deuten. Unter Verwendung eines psychologischen Ansatzes soil deutlich gemacht werden, daB dem individuellen Sprachgestus Bernhards eine spezifische psychische Befindlichkeit des Protagonisten Roithamers korreliert, die erkla‐ren kann, warum die in diesem Roman entwickelte Kunstutopie nicht realisiert werden kann.Der Versuch Bernhards, den in der Korrektur etablierten Kunstkosmos gegen alle störenden Tendenzen von außen abzu‐schließen, weist dezidiert paranoische Tendenzen auf. Allerdings schließen sich diese Tendenzen nicht zu einem (Wahn‐) System, so daß der Kiinstler Roithamer am Ende an einem ästhetischen Absolutheitsanspruch scheitert, der von der modernen Kunst nicht mehr eingefordert werden kann.Es ist jeweils die Welt des Dichters, die zugrunde geht, und zwar eine erdichtete Welt, die von vornher‐ein gezeichnet und zum Untergang bestimmt ist, ein Reich, das geschaffen ist, um zu vergehen, eine Welt des Verfalls und des Untergangs (H. Petriconi: Das Reich des Untergangs: Bemerkun‐gen über ein mythologisches Thema. Hoffmann & Campe, S. 15. (Hamburg 1958)
Bone healing in critical‐size defects treated with platelet‐rich plasma: a histologic and histometric study in rat calvaria
Authors: Messora M. R. , Nagata M. J. H. , Mariano R. C. , Dornelles R. C. M. , Bomfim S. R. M. , Fucini S. E. , Garcia V. G. , Bosco A. F. 
Published: August 2007

Background and Objective:  The purpose of this study was to analyze histologically the influence of autologous platelet‐rich plasma on bone healing in surgically created critical‐size defects in rat calvaria.Material and Methods:  Thirty‐two rats were divided into two groups: the control group (group C) and the platelet‐rich plasma group. An 8‐mm‐diameter critical‐size defect was created in the calvarium of each animal. In group C the defect was filled by a blood clot only. In the platelet‐rich plasma group, 0.35 mL of platelet‐rich plasma was placed in the defect and covered by 0.35 mL of platelet‐poor plasma. Both groups were divided into subgroups (n = 8) and killed at either 4 or 12 wk postoperatively. Histometric (using image‐analysis software) and histologic analyses were performed. The amount of new bone formed was calculated as a percentage of the total area of the original defect. Percentage data were transformed into arccosine for statistical analysis (analysis of variance, Tukey, p < 0.05).Results:  No defect completely regenerated with bone. The platelet‐rich plasma group had a statistically greater amount of bone formation than group C at both 4 wk (17.68% vs. 7.20%, respectively) and 12 wk (24.69% vs. 11.65%, respectively) postoperatively.Conclusion:  Within the limits of this study, it can be concluded that platelet‐rich plasma placed in the defects and covered by platelet‐poor plasma significantly enhanced bone healing in critical‐size defects in rat calvaria.
Side effects of HIV therapy
Authors: Esser Stefan , Helbig Doris , Hillen Uwe , Dissemond Joachim , Grabbe Stephan 
Published: August 2007

SummaryThe use of highly active effective antiretroviral therapies (ART) has dramatically decreased the morbidity and mortality of the HIV infection. Over 20 anti‐retroviral substances are available in four different classes. Side effects of HIV therapy are common and may influence the prognosis, as the medications are required lifelong for the still incurable infection. ART‐associated allergic reactions, lipodystrophy syndrome and immune reconstitution syndrome are side effects frequently seen by dermatologists. Exanthems are challenging as drug reactions must be separated from immune reconstitution, syphilis and viral exanthems and then the causative agent must be identified from a long list of medications. Non‐nucleoside reverse transcriptase inhibitors typically cause allergic exanthems. Mitochondrial toxicity caused by nucleoside reverse transcriptase inhibitors is responsible for lipoatrophy and fatty changes in the liver. Protease inhibitors cause diarrhea, abnormalities of glucose and fat metabolism and lipohypertrophy. Before other medications or surgical measures are undertaken to address side effects of ART, the regimen should be adjusted to include alternative but equally effective agents.
Cutaneous leishmaniasis: Clinical report of two cases and review of the recent literature
Authors: Valesky Eva Maria , Thaçi Diamant , Meissner Markus , Beier Christian , Wolter Manfred , Schöfer Helmut , Kaufmann Roland 
Published: August 2007

SummaryWith 1–1.5 million cases reported every year cutaneous leishmaniasis represents an increasing health problem. The course of cutaneous leishmaniasis varies from a single self‐healing ulcer to a persistent ulcer or progressive mucosal disease with nasopharyngeal destruction. An enormous array of topical and systemic treatment modalities has been endorsed. The response to treatment depends on the species of parasite as well as the host's immunological and genetic status. Species‐specific treatment guidelines based on evidence from controlled studies are highly desirable. We present two cases of cutaneous leishmaniasis, one in a child and one during pregnancy, reviewing various diagnostic and therapeutic measures with special attention to problems in young and pregnant patients.
A woman with a dangling digit
Authors: Roesch Alexander , Kinner Bernd , Schaechinger Ulrich , Obermann Ellen C. , Landthaler Michael , Hohenleutner Ulrich 
Published: August 2007

SummaryAinhum (dactylolysis spontanea) is a distinct clinical and radiological disorder of dark‐skinned people characterized by a progressive development of a constricting band encircling the toe which usually results in spontaneous amputation. Ainhum mainly occurs in African natives, but in times of global migration and tourism, Ainhum is likely to be more often encountered outside Africa. Even though the clinical presentation can mimic more common entities such as arthritis and trauma, the correct diagnosis and treatment is easy if one knows this unusual entity.
Embolia cutis medicamentosa following subcutaneous injection of glatiramer acetate
Authors: Harde Viola , Schwarz Thomas 
Published: August 2007

SummaryEmbolia cutis medicamentosa (ECM) is a rare side effect observed primarily after intramuscular injections. It is associated with localized, sometimes extensive necrosis of the skin. Reflex vasospasm induced by the injection trauma may be etiologically involved. It is a potentially serious reaction which is little influenced by which drug is injected. A patient developed typical ECM after subcutaneous selfinjection of glatiramer acetate for multiple sclerosis. This case is remarkable since 1) ECM developed after subcutaneous and not after intramuscular injection, 2) the injection was given by the patient himself, and 3) glatiramer acetate can induce skin necrosis as a side effect. ECM can be easily differentiated from the latter by its typical clinical features.
Diagnosis of oral squamous cell carcinoma and its precursor lesions
Authors: Driemel Oliver , Kunkel Martin , Hullmann Markus , Eggeling Ferdinand von , Müller‐Richter Urs , Kosmehl Hartwig , Reichert Torsten E. 
Published: August 2007

SummaryImprovement of survival rate and quality of life after treatment of oral squamous cell carcinoma as well as cost reduction requires reliable early diagnosis of the tumor and its precursor lesions. Four different screening methods are primarily employed: toluidine blue staining (visually detected lesions: sensitivity 70–100%, specificity 25–67%), photodynamic diagnosis (sensitivity 94–99%, specificity 60–89%), autofluorescence (no data published so far) and modern oral cytology (sensitivity 80%,specificity 95–100%).Additional analytic procedures such automated image analysis, DNA image cytometry and immunocytochemistry can be used to enhance the low sensitivity of conventional oral cytology.While these methods have achieved sensitivity and specificity approaching 100%, the studies involved clearly‐defined entities such as large oral squamous cell carcinomas and aphthae. The modern and methodenhanced oral cytology is a simple, value‐based and inexpensive tool for early diagnosis of oral squamous cell carcinoma and its precursor lesions. Surgical biopsy and histopathological examination remains the gold standard for definitive diagnosis.
Anaphylactic reaction to lupine flour
Authors: Brennecke Sabine , Becker Wolf‐Meinhard , Lepp Ute , Jappe Uta 
Published: August 2007

SummaryRoasted lupine seeds have been used as snack food in Mediterranean countries for years. Since the 1990s, lupine flour has been used as a substitute for or additive to other flours in countries of the European Union; usually the amount is so low that no declaration is required. Since 1994, a number of cases of immediate‐type allergy to lupine flour‐containing products have been published. A 52‐year‐old woman developed facial and mucosal edema, followed by dizziness and shortness of breath a few minutes after ingestion of a nut croissant con‐taining lupine flour; she required emergency care. Allergy diagnostic tests revealed a total IgE of 116 kU/l, a highly elevated concentration of IgE specific for lupine seed (42.9 kU/l) and birch pollen IgE of 2.57 kU/l. Skin prick test with native lupine flour was strongly positive. Allergy against lupine seeds may develop de novo or via cross‐reactivity to legumes, particularly peanuts, the latter being detectable in up to 88% of cases, founded on a strong sequence similarity between lupine and peanut allergens. In our patient, no cross‐reactivity could be detected via immunoblotting, indicating a rare monovalent sensitization to lupine flour. Treatment consists of avoidance of lupine flour‐containing products. Patients with proven peanut allergy should also avoid lupine flour because of the major risk of cross‐reaction.