bluuebunny/crossref_metadata_2025_split huggingface dataset:
True significance of the number of retrieved lymph nodes in stage II colon cancer resected by minimally invasive surgery: Influence of tumor sidedness
Authors: Iguchi Kenta , Sugiyama Atsuhiko , Mushiake Hiroyuki , Hasegawa Seiji , Rino Yasushi , Saito Aya , Shiozawa Manabu 
Published: April 2024

AbstractBackgroundIn patients with stage II colon cancer (CC) undergoing minimally invasive surgery, the association between the clinical significance of lymph node yield and tumor localization remains unknown. We aimed to determine the optimal number of lymph nodes to be retrieved based on tumor localization in patients with stage II CC undergoing minimally invasive surgery.MethodsThis was a multicenter retrospective study. Overall, 263 patients with stage II CC who underwent laparoscopic surgery between January 1, 2008 and December 31 were enrolled. The primary outcome was the optimal number of lymph nodes retrieved based on tumor localization.ResultsThe median number of retrieved lymph nodes was 30 and 26 in the right‐(n = 125) and left‐sided (n = 138) CC groups, respectively (p = .0007). Inadequate dissection (<12 nodes) occurred in 4.2% of patients: 1.6% in the right‐sided CC group and 6.5% in the left‐sided CC group. Multivariate Cox regression analysis showed a decreasing trend in adjusted hazard ratios with increasing nodes, with an optimal cutoff of 15 lymph nodes in the left‐sided CC group (adjusted hazard ratio, 5.868; 95% confidence interval, 1.247–27.62; p = .02). Lymph node yield was not independently associated with survival in the right‐sided CC group.ConclusionsFor patients with left‐sided stage II CC undergoing laparoscopic surgery, aiming for at least 15 retrieved lymph nodes may be optimal for accurate staging and prognostic assessment. The optimal lymph node yield likely varies based on tumor location, requiring further investigation in right‐sided CC.
Meta‐analysis of the effect of 360‐degree videos on students' learning outcomes and non‐cognitive outcomes
Authors: Jiang Zhujun , Zhang Yicong , Chiang Feng‐Kuang 
Published: April 2024

AbstractA 360‐degree video offers a novel visual experience for education. This immersive experience not only amplifies students' engagement and curiosity but also assists them in delving into and comprehending intricate concepts from a multitude of viewpoints. Given its novelty, there is a relative shortage of studies on 360‐degree video's overall effectiveness in education. This study conducted a meta‐analysis of 49 peer‐reviewed articles. Utilizing a random‐effects model to compute effect sizes (ES), the results showed that 360‐degree videos have a moderate impact on both learning (Hedges' g = 0.525) and non‐cognitive outcomes (Hedges' g = 0.527), with notable heterogeneity observed across the studies. Furthermore, the studies were coded to examine the moderating effects of their characteristics, such as the level of education, the field of education, the display types, experimental design, the sample size and the control treatment. The findings suggest a medium effect of 360‐degree videos on knowledge acquisition and a smaller effect on task performance. In terms of non‐cognitive outcomes, the least impact was noted in the domain of social and emotional qualities, while the most significant impact was in attitudes and beliefs. Based on these findings, the study proposed future research directions focusing on enhancing teaching strategies and improving research designs concerning the use of 360‐degree videos in educational contexts.Practitioner notesWhat is already known about this topic

360‐degree videos in education are notable for their authenticity, flexibility and accessibility.
They enhance learners' sense of presence, deepen understanding of subject matter and improve non‐cognitive skills.
360‐degree videos have produced mixed results on learning and non‐cognitive outcomes.
What this paper adds

360‐degree videos have a medium effect on students' learning outcomes (g = 0.0.525) and non‐cognitive outcomes (g = 0.0.527).
Significant heterogeneity is observed in the effects of 360‐degree videos on both learning outcomes and non‐cognitive outcomes.
In terms of non‐cognitive outcomes, 360‐degree videos have the smallest effect size in the social and emotional qualities domain.
Identifying key moderators that influence the effectiveness of 360‐degree videos, including participants' education levels, field of application, sample sizes, display types, experimental designs and control treatment.
Implications for practice and/or policy

Enhance social and emotional learning with 360‐degree video, and aid in understanding and managing emotional experiences.
Develop learning strategies that align with the unique characteristics of different subjects.
Teacher‐assisted approaches are encouraged to support learning and teaching in formal educational settings with structured courses.
Multimodal data can be collected for analysis in future research to explore the learning process.
Optical coherence tomography assessment of disease activity in cryopyrin‐associated periodic syndrome
Authors: Mulazzani E. , Böhm L. , Christmann T. , Krumbholz M. , Kümpfel T. , Havla J. 
Published: April 2024

AbstractBackground and purposeCryopyrin‐associated periodic syndrome is a rare autoinflammatory disease caused by gain‐of‐function mutations or variants in the NLRP3 gene. Clinically, patients suffer from a broad spectrum of both systemic and neurological symptoms. The aim of this study was to determine whether systemic inflammation demonstrated by serum amyloid A (SAA) elevation is associated with neuroinflammation assessed by optical coherence tomography (OCT).MethodsThirty eyes of 15 patients with NLRP3 low penetrance mutations (PwNLRP3) and 20 eyes of 10 age‐ and sex‐matched healthy controls were examined by spectral‐domain OCT as part of routine clinical care. All retinal layers and clinical features were evaluated.ResultsAt baseline no significant retinal neuroaxonal inflammation or degeneration was observed in all measured retinal layers amongst PwNLRP3 compared with healthy controls. In a pooled analysis of all individual OCT time points a significant difference regarding the macular retinal nerve fibre layer was detected. Increased levels of SAA showed a positive association with averaged combined outer plexiform layer and outer nuclear layer volumes (ρ < 0.0001, r2 = 0.35).ConclusionIn cryopyrin‐associated periodic syndrome increased combined outer plexiform layer and outer nuclear layer volumes are mirrored by SAA increase, an acute phase reactant indicating systemic inflammation. Our findings identify OCT as a candidate biomarker to monitor subclinical neuroinflammation and to assess disease activity in PwNLRP3.
TYK2 inhibition with deucravacitinib ameliorates erosive oral lichen planus
Authors: Stolte Kim Natalie , Mesas‐Fernández Alberto , Meier Katharina , Klein Edis Kaan , Dommisch Henrik , Ghoreschi Kamran , Solimani Farzan 
Published: April 2024

AbstractErosive oral lichen planus (OLP) is a challenging disease. This T cell driven disorder frequently shows a treatment unresponsive course and strongly limits patients' quality of life. The disease lacks FDA or EMA approved drugs for its treatment and the efficacy of the commonly administered treatments (i.e. topical and systemic steroids, steroid sparing agents) is often only partial. Although the etiopathogenesis of the disease still needs to be fully elucidated, recent advances helped to identify interferon‐ɣ (IFN‐ɣ) as a pivotal cytokine in OLP pathogenesis, thus making the interference with its signalling a therapeutic target. Janus kinase (JAK) inhibitors therefore gained relevance for their inhibitory effect on IFN‐ɣ signalling. While some drugs such as abrocitinib, upadacitinib, tofacitinib directly interfere with IFN‐ɣ signalling through blockade of JAK1 and/or JAK2, deucravacitinib, a selective TYK‐2 inhibitor indirectly interferes on IFN‐ɣ activation through interference with interleukin (IL)‐12, a potent promotor for Th1/IFN‐ɣ responses. This mechanism of action makes deucravacitinib a candidate drug for the treatment of OLP. Here we provide initial evidence that deucravacitinib 6 mg daily has a beneficial effect in three patients with oral OLP.
RETRACTED: Meta‐analysis comparing different ultrasound detection methods to accurately assess wound healing and scar formation after caesarean section
Authors: Miao Jing‐Jing , Luo Ying‐Ying , Wang Chen‐Yu , Li Hui‐Xia , Yu Hong‐Xia 
Published: April 2024

AbstractThe accurate assessment of wound healing post‐caesarean section, especially in twin pregnancies, remains a pivotal concern in obstetrics, given its implications for maternal health and recovery. Traditional methods, including conventional abdominal ultrasonography (CU), have been challenged by the advent of transvaginal ultrasonography (TU), offering potentially enhanced sensitivity and specificity. This meta‐analysis directly compares the efficacy of TU and CU in evaluating wound healing and scar formation, crucial for optimizing postoperative care. Results indicate that TU is associated with significantly better outcomes in wound healing, demonstrated by lower REEDA scores (SMD = −20.56, 95% CI: [−27.34.20, −13.77], p < 0.01), and in scar formation reduction, evidenced by lower Manchester Scar Scale scores (SMD = −25.18, 95% CI: [−29.98, −20.39], p < 0.01). These findings underscore the potential of integrating TU into routine post‐caesarean evaluation protocols to enhance care quality and patient recovery.
Contraction and expansion: global geographical variation in reproductive systems of Primula is driven by different mechanisms
Authors: Shi Honghua , Yang Bin , Lyu Tong , Wang Zhiheng , Sun Hang 
Published: April 2024

AbstractAimReproductive systems strongly influence plants' evolution and adaption, and the biogeographic pattern of its variation has intrigued biologists and ecologists. Here, to test the impacts of paleoglaciation on plants' reproductive system variation, we compared the geographical pattern and environmental drivers in the proportions of different reproductive systems in Primula in regions affected and unaffected by paleoglaciation.LocationGlobal.Time PeriodSince the Last Glacial Maximum (LGM).Major Taxa Studied
Primula.
MethodsUsing data on reproductive systems and distributions of 604 Primula taxa around the world and 221 along the elevational gradient of the Himalayas, we demonstrated the global pattern and the elevational pattern in the proportions of homostylous taxa. We employed general linear models to establish the relationship between the proportion of homostylous taxa and environmental variables and hierarchical partitioning to assess the relative contributions of these variables in both regions affected and unaffected by paleoglaciation, respectively.ResultsWe found a higher proportion of homostylous taxa in regions glaciated during the LGM than those unglaciated, with different latitudinal patterns and climate drivers. The proportion of homostylous taxa showed varying trends across different regions: increasing with latitude and temperature anomaly in glaciated regions while concentrating at lower latitudes with higher winter temperatures in unglaciated regions. Additionally, homostylous taxa were more prevalent at lower elevations in the Himalayas.Main ConclusionsOur study provides the first quantitative evidence for the hypothesis that selfers are more prevailing in regions affected by paleoglaciation facilitated by recolonization via comparing the geographic pattern and drivers in regions affected and unaffected by paleoglaciation. Our findings also reveal the concentrated distribution of homostylous taxa in Primula at low latitudes, which may be the result of population shrinkage caused by heat stress, facing a more severe survival crisis under the circumstances of global warming and increasing human activities.
Predictable time‐series biases in analyst target prices and stock returns
Authors: Vafaeimehr Ahmadreza 
Published: April 2024

AbstractTarget prices often draw criticism because of their optimistic nature and lack of substantial investment value. I provide evidence that removing predictable time‐series biases in target prices significantly improves the information content of these estimates. Empirical tests do not support that these benefits stem from market underreaction to predictable biases. Instead, evidence indicates the informativeness of unbiased estimates about priced risk factors beyond common factors. Unbiasing target prices may improve their ability to capture time‐series momentum. Finally, I delve into the methodological facets of the unbiasing procedure, leading to the development of frameworks that possess tangible practical relevance.
Risk stratification of synchronous gastric cancers including alcohol‐related genetic polymorphisms
Authors: Asonuma Sho , Hatta Waku , Koike Tomoyuki , Okata Hideki , Uno Kaname , Iwai Wataru , Saito Masashi , Yonechi Makoto , Fukushi Daisuke , Kayaba Shoichi , Kikuchi Ryosuke , Ito Hirotaka , Fushiya Jun , Maejima Ryuhei , Abe Yasuhiko , Kawamura Masashi , Honda Junya , Kondo Yutaka , Dairaku Naohiro , Toda Shusuke , Watanabe Kenta , Takahashi Kiichi , Echigo Hiroharu , Abe Yasuaki , Endo Hiroyuki , Okata Tomoki , Hoshi Tatsuya , Kinoshita Kenji , Kisoi Madoka , Nakamura Tomohiro , Nakaya Naoki , Iijima Katsunori , Masamune Atsushi 
Published: April 2024

AbstractBackground and AimWe previously identified that ever‐smoking and severe gastric atrophy in pepsinogen are risk factors for synchronous gastric cancers (SGCs). This study aimed to determine the association of alcohol drinking status or alcohol‐related genetic polymorphism with SGCs and also stratify their risk.MethodsThis multi‐center prospective cohort study included patients who underwent endoscopic submucosal dissection for the initial early gastric cancers at 22 institutions in Japan. We evaluated the association of alcohol drinking status or alcohol dehydrogenase 1B (ADH1B) and acetaldehyde dehydrogenase 2 (ALDH2) genotypes with SGCs. We then stratified the risk of SGCs by combining prespecified two factors and risk factors identified in this study.ResultsAmong 802 patients, 130 had SGCs. Both the ADH1B Arg and ALDH2 Lys alleles demonstrated a significant association with SGCs on multivariate analysis (odds ratio, 1.77), although alcohol drinking status showed no association. The rates of SGCs in 0–3 risk factors in the combined evaluation of three risk factors (ever‐smoking, severe gastric atrophy in pepsinogen, and both the ADH1B Arg and ALDH2 Lys alleles) were 7.6%, 15.0%, 22.0%, and 32.1%, respectively. The risk significantly increased from 0 to 3 risk factors on multivariate analysis (P for trend <0.001).ConclusionsBoth the ADH1B Arg and ALDH2 Lys alleles were at high risk for SGCs. The risk stratification by these three factors may be a less invasive and promising tool for predicting their risk.
Mitigation of retinol‐induced skin irritation by physiologic lipids: Evidence from patch testing
Authors: Fang Ye , Ying Ye , Xiaolan Wei , Lin Sun , Chenlan Xu , Caixia Wang , Dingqiao Lin , Yanan Li 
Published: April 2024

AbstractBackgroundThere is a dearth of effective treatments to counter retinol‐induced skin irritation.ObjectiveThis study aimed to investigate the efficacy of three potential mitigants: (i) phytosteryl/octyldodecyl lauroyl glutamate (PLG), (ii) a physiologic lipid mixture (PLM) comprised of ceramide three and cholesterol, and (iii) niacinamide, in ameliorating irritation instigated by retinol.MethodsAn occlusive human patch test, spanning 5 days, was undertaken on 18 Chinese participants aged between 23 and 40. It was designed as a randomized, double‐blind, and vehicle‐controlled study. Clinician erythema assessment (CEA) and instrumental evaluations were employed pre and post‐test. Subsequently, a 4‐week consumer in‐use test, randomized and double‐blind in nature, was executed to substantiate the soothing effects of PLG.ResultsData from CEA and bioengineering assessments revealed that, in comparison to the vehicle control, both 2% PLG and 5% PLM notably curbed retinol‐induced skin erythema and inflammation. Notably, PLG outperformed PLM. Conversely, 3% niacinamide did not offer relief against retinol‐induced discomfort. The subsequent consumer in‐use test affirmed that treatments with 2% PLG were better tolerated than those with the vehicle alone.ConclusionTo the best of our knowledge, this study represents the first confirmation that physiologic lipids effectively mitigate retinol‐induced irritation. Given their capacity to counter retinol‐induced irritation, physiologic lipids, particularly PLG, are recommended for incorporation in retinol regimens. Additionally, the Visia‐CR a* value can serve as a robust objective measure for interpreting patch test outcomes.
Low‐temperature thermal and physical properties of lunar meteorites
Authors: Macke R. J. , Opeil C. P. , Britt D. T. , Consolmagno G. J. , Irving A. 
Published: April 2024

AbstractLunar meteorites are the most diverse and readily available specimens for the direct laboratory study of lunar surface materials. In addition to informing us about the composition and heterogeneity of lunar material, measurements of their thermo‐physical properties provide data necessary to inform the models of the thermal evolution of the lunar surface and provide data on fundamental physical properties of the surface material for the design of exploration and resource extraction hardware. Low‐temperature data are particularly important for the exploration of low‐temperature environments of the lunar poles and permanently shadowed regions. We report low‐temperature‐specific heat capacity, thermal conductivity, and linear thermal expansion for six lunar meteorites: Northwest Africa [NWA] 5000, NWA 6950, NWA 8687, NWA 10678, NWA 11421, and NWA 11474, over the range 5 ≤ T ≤ 300 K. From these, we calculate thermal inertia and thermal diffusivity as functions of temperature. Additionally, heat capacities were measured for 15 other lunar meteorites, from which we calculate their Debye temperature and effective molar mass.
Well‐being and dignity in innovative digitally‐led healthcare for aged adults
Authors: Raja Moonika , Uhrenfeldt Lisbeth 
Published: April 2024

AbstractDignity is a central value in care for aged adults, and it must be protected and respected. With demographic changes leading to an aging population, health ministries are increasingly investing in digitalization. However, using unfamiliar digital technology can be challenging and thus impact aged adults' dignity and well‐being. The INNOVATEDIGNITY project aims to research new, dignified ways of engaging with aged adults to shape digital developments in care delivery. This qualitative study aimed to explore how innovative digitally‐led healthcare have influenced aged adults' well‐being and dignity through three studies conducted as part of the INNOVATEDIGNITY project: a scoping review, an empirical study and a policy analysis. The three documents were analysed to uncover meanings relevant to the research problem revealing four main themes: the advantages of new technologies in facilitating aged adults' well‐being, the rupture of dignity due to bewilderment in the digital world, aged adults' dignity is affected by their worries about human face of care being replaced by technology and preserving aged adults' dignity in digitally‐led healthcare. Digitalization in healthcare impacts aged adults' well‐being as providing new opportunities for care, but preserving aged adults' dignity when working with unfamiliar digital innovations is challenging. Aged adults need to be informed about the use of technology in their care and supported to develop the necessary digital skills to better adapt to digitally‐led healthcare. The circumstances, conditions and needs of individuals should remain central when implementing new technologies in healthcare settings in a dignified way.
Long‐term outcome of pediatric renal transplantation with donors younger than 6 years
Authors: Ramirez‐Amoros Carla , San Basilio Maria , Amesty Virginia , Rivas Susana , Lobato Roberto , Fernandez‐Camblor Carlota , Lopez‐Pereira Pedro , Martinez‐Urrutia Maria Jose 
Published: April 2024

AbstractBackgroundRenal transplantation is currently the best treatment option for patients with end‐stage renal disease. However, the use of kidneys from donors under 6 years of age as a possibility to increase the organ pool in pediatric recipients remains a controversial matter. We aimed to investigate whether donor age is associated to the long‐term functionality of the renal graft. Likewise, we analyzed the adaptation of the graft to the ascending functional requirements in the pediatric patient.MethodsRetrospective study of the results obtained in pediatric recipients transplanted with grafts from donors between 3 and 6 years of age, comparing them with those of grafts from donors older than 6 years. Among the variables compared are cumulative graft survival, renal size, need for antiproteinuric therapy, GFR, incidence of rejection, pyelonephritis, renal failure and surgical or tumor complications.ResultsA total of 43 transplants were performed with donors aged 3–6 years, and 42 transplants with donors older than 6 years. Cumulative graft survival at 5 years was 81% for the younger donor group compared to 98% for the older donor group (p < .05). At 8 years, cumulative graft survival for donors <6 years was 74%. As for the mean estimated graft survival, it was 11.52 years for the younger donor group and 14.51 years for older donors. During follow‐up, the younger donor group presented greater renal enlargement and need for antiproteinuric therapy. The older donors group had a higher GFR during the first year of follow‐up, which then equalized in both groups. There were no statistically significant differences in the incidence of acute or chronic rejection, acute pyelonephritis, acute renal failure or surgical or tumor complications.ConclusionsRenal transplants of grafts equal to or less than 6 years old have good short‐term and acceptable long‐term results in pediatric patients.
Schopenhauer on the inconsistency between optimism and personal immortality
Authors: Segev Mor 
Published: April 2024

AbstractFor Schopenhauer, death, understood as the annihilation of an individual's existence, cannot be successfully accommodated by theories endorsing an optimistic assessment of both human life and the world at large. I argue that Schopenhauer also has reasons to think that optimism cannot adopt personal immortality as a solution to that problem, although he does not present them systematically. Thus, he argues, prolonging one's life would necessarily lead at some point to an unbearable state of exhaustion due to one's unchanging character. Changing one's character infinitely many times in the future would not do either, as Schopenhauer regards that idea as internally inconsistent. Finally, the immortality gained through one's work, one's descendants, or the survival of a part of oneself, while consistent with optimism, could not amount to personal immortality, on Schopenhauer's criteria. I end by discussing the implications of Schopenhauer's criticism for his own view, and a possible reply to it.