bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Hemerocallis essence aroma on brain activity and sleep processes via scalp electroencephalogram
Authors: Ke Qinfei , Yang Jiaqi , Zhu Jiancai , Meng Qingran , Zhang Yunchong , Guo Yihao , Niu Yunwei , Liu Qinglei , Huang Xin , Kou Xingran 
Published: April 2024

AbstractSleep disorders are widespread. Inhaled aromatherapy has shown advantages over medication in treating insomnia. Daylily (Hemerocallis fulva) has been found to positively affect sleep either by ingestion or inhalation, but there is a lack of research on the sleep aid effect of its inhalation route. At present, the floral scent characteristics of daylily are not obvious, and the extraction rate of essential oil is low. Based on the above problems, this study developed daylily essence which replicates the natural aroma of plants and investigated the effect of inhaling daylily essence aroma on sleep activity by using Pittsburgh Sleep Quality Index (PSQI) and electroencephalogram (EEG). According to PSQI results, inhaling the aroma of daylily essence improved participants' subjective sleep quality. The difference between men and women was statistically significant (p < .05). The slow‐wave sleep activity of EEG in the experimental group was significantly stronger than that in the control group (p < .01). In addition, the frontal and central regions were more responsive to aroma stimuli (p < .05). The results of this study show that the aroma of daylily can promote the subjective and objective sleep quality of healthy college students, and the use of fragrance intervention is a potential scheme to improve sleep quality and insomnia.
Medicinal utilization and nutritional properties of drumstick (Moringa oleifera)—A comprehensive review
Authors: Zarina  , Wani Ab Waheed , Rawat Monisha , Kaur Harjinder , Das Sachitanand , Kaur Taranpreet , Akram Noor , Faisal Zargham , Jan Syed Saad , Oyshe Nabila Nusrat , Khan Mahbubur Rahman , Shah Yasir Abbas 
Published: April 2024

AbstractThe tropical and subtropical regions of the world support the growth of the Indian plant Moringa oleifera. It usually goes by the name drumstick tree or horseradish tree and thrives in warm climates. The leaves of the M. oleifera tree are now frequently used as nutrients and nutraceuticals due to their availability of various minerals. While having only very minor antinutritional effects, the leaves are abundant in many beneficial compounds. A recent review of the bioactive components and activity of moringa leaves has focused on both in vivo and in vitro studies. Drumstick leaves have antidiabetic qualities, anti‐inflammatory, anticancer, and antibacterial qualities among other health benefits. Phytochemicals, in addition to minerals and vitamins, are abundant in this vegetable. The majority of these effects, according to a review in the literature, are mostly brought on by the presence of carotenoids, glucosinolates, and phytochemicals. As a value‐added component in the production of wholesome meals, moringa is becoming more popular. Despite extensive research into locating and quantifying these advantageous elements in drumstick leaves, bioavailability and bioaccessibility studies were carried out. Beneficial photochemicals are absorbed and digested through incredibly intricate processes that involve several physicochemical and physiological interactions. Therefore, the biological impact of food may be attributed to its various metabolites that can access particular areas of action rather than its original substances. This body of literature offers the most recent findings in scientific research on the bioavailability, health advantages, nutritional profiles, and bioactive activities of moringa leaves as they relate to their use in a range of food products. Drumsticks are frequently used as a food element that promotes health because of their potent protection against a variety of ailments and the presence of environmental pollutants.
Sexually dimorphic effects of pexidartinib on nerve injury‐induced neuropathic pain in mice
Authors: Saika Fumihiro , Fukazawa Yohji , Hatano Yu , Kishioka Shiroh , Hino Yuko , Hino Shinjiro , Suzuki Kentaro , Kiguchi Norikazu 
Published: April 2024

AbstractIt is well‐established that spinal microglia and peripheral macrophages play critical roles in the etiology of neuropathic pain; however, growing evidence suggests sex differences in pain hypersensitivity owing to microglia and macrophages. Therefore, it is crucial to understand sex‐ and androgen‐dependent characteristics of pain‐related myeloid cells in mice with nerve injury‐induced neuropathic pain. To deplete microglia and macrophages, pexidartinib (PLX3397), an inhibitor of the colony‐stimulating factor 1 receptor, was orally administered, and mice were subjected to partial sciatic nerve ligation (PSL). Following PSL induction, healthy male and female mice and male gonadectomized (GDX) mice exhibited similar levels of spinal microglial activation, peripheral macrophage accumulation, and mechanical allodynia. Treatment with PLX3397 significantly suppressed mechanical allodynia in normal males; this was not observed in female and GDX male mice. Sex‐ and androgen‐dependent differences in the PLX3397‐mediated preventive effects were observed on spinal microglia and dorsal root ganglia (DRG) macrophages, as well as in expression patterns of pain‐related inflammatory mediators in these cells. Conversely, no sex‐ or androgen‐dependent differences were detected in sciatic nerve macrophages, and inhibition of peripheral CC‐chemokine receptor 5 prevented neuropathic pain in both sexes. Collectively, these findings demonstrate the presence of considerable sex‐ and androgen‐dependent differences in the etiology of neuropathic pain in spinal microglia and DRG macrophages but not in sciatic nerve macrophages. Given that the mechanisms of neuropathic pain may differ among experimental models and clinical conditions, accumulating several lines of evidence is crucial to comprehensively clarifying the sex‐dependent regulatory mechanisms of pain.
Attention‐deficit hyperactivity disorder symptoms and brain morphology: Addressing potential selection bias with inverse probability weighting
Authors: Dijkzeul Annet , Tiemeier Henning , Muetzel Ryan L. , Labrecque Jeremy A. 
Published: April 2024

AbstractThe goal of this study was to examine what happens to established associations between attention deficit hyperactivity disorder (ADHD) symptoms and cortical surface and thickness regions once we apply inverse probability of censoring weighting (IPCW) to address potential selection bias. Moreover, we illustrate how different factors that predict participation contribute to potential selection bias. Participants were 9‐ to 11‐year‐old children from the Generation R study (N = 2707). Cortical area and thickness were measured with magnetic resonance imaging (MRI) and ADHD symptoms with the Child Behavior Checklist. We examined how associations between ADHD symptoms and brain morphology change when we weight our sample back to either follow‐up (ages 9–11), baseline (cohort at birth), or eligible (population of Rotterdam at time of recruitment). Weights were derived using IPCW or raking and missing predictors of participation used to estimate weights were imputed. Weighting analyses to baseline and eligible increased beta coefficients for the middle temporal gyrus surface area, as well as fusiform gyrus cortical thickness. Alternatively, the beta coefficient for the rostral anterior cingulate decreased. Removing one group of variables used for estimating weights resulted in the weighted regression coefficient moving closer to the unweighted regression coefficient. In addition, we found considerably different beta coefficients for most surface area regions and all thickness measures when we did not impute missing covariate data. Our findings highlight the importance of using inverse probability weighting (IPW) in the neuroimaging field, especially in the context of mental health‐related research. We found that including all variables related to exposure‐outcome in the IPW model and combining IPW with multiple imputations can help reduce bias. We encourage future psychiatric neuroimaging studies to define their target population, collect information on eligible but not included participants and use inverse probability of censoring weighting (IPCW) to reduce selection bias.
A Multiplex Recombinase‐Aided qPCR Assay for Highly Sensitive and Rapid Detection of khe, blaKPC‐2, and blaNDM‐1 Genes in Klebsiella pneumoniae
Authors: Hua Shao‐wei , Wang Jie , Zhao Zi‐jin , Tian Feng‐yu , Zhao Meng , Wang Yu‐xin , Zhang Rui‐qing , Han Zhi‐qiang , Gao Shi‐jue , Lv Xiao‐na , Li Hong‐yi , Shen Xin‐xin , Ma Xue‐jun , Feng Zhi‐shan 
Published: April 2024

ABSTRACTObjectiveThis study aimed to establish a highly sensitive and rapid single‐tube, two‐stage, multiplex recombinase‐aided qPCR (mRAP) assay to specifically detect the khe, blaKPC‐2, and blaNDM‐1 genes in Klebsiella pneumoniae.MethodsmRAP was carried out in a qPCR instrument within 1 h. The analytical sensitivities of mRAP for khe, blaKPC‐2, and blaNDM‐1 genes were tested using recombinant plasmids and dilutions of reference strains. A total of 137 clinical isolates and 86 sputum samples were used to validate the clinical performance of mRAP.ResultsmRAP achieved the sensitivities of 10, 8, and 14 copies/reaction for khe, blaKPC‐2, and blaNDM‐1 genes, respectively, superior to qPCR. The Kappa value of qPCR and mRAP for detecting khe, blaKPC‐2, and blaNDM‐1 genes was 1, 0.855, and 1, respectively (p < 0.05).ConclusionmRAP is a rapid and highly sensitive assay for potential clinical identification of khe, blaKPC‐2, and blaNDM‐1 genes in K. pneumoniae.
Selenium suppressed growth of Ehrlich solid tumor and improved health of tumor‐bearing mice
Authors: Hekal Heba A. , Amer Maggie E. , Amer Maher , El‐Missiry Mohamed A. , Othman Azza I. 
Published: April 2024

AbstractSelenium (Se) is an important micronutritional biomolecule in cancer therapy. The current work evaluated the anticancer effect of Se and its ability to improve health of mice with solid Ehrlich carcinoma implanted subcutaneously. Four groups of five female BALB/c mice each were assembled. Ehrlich tumor cells were engrafted into two of them, either with or without Se therapy. The other groups served as control groups, either with or without Se treatment. Se treatment resulted in a notable decrease in both tumor volume and animal body mass in tumor‐bearing mice. Treatment with Se markedly increased oxidative stress in tumor while ameliorating oxidative stress in sera of tumors‐bearing mice. Similarly, treatment with Se resulted in downregulation of inflammatory cytokines (TNF‐α and IL‐6) while increasing IL‐10 in serum of tumor‐bearing mice. Conversely, selenium increased TNF‐ α and IL‐6 and decreased IL‐10 in tumor suggesting disruption of tumor immunity. The increased oxidative stress and inflammation in tumor tissue dysregulated cell cycle phases with increase apoptotic tumor cells population in G0/G1 phase. This is supported by the increased levels apoptotic regulating proteins (Bax and caspase‐3 and P‐53) while decreasing Bcl‐2 in the tumor tissue. Treatment with Se also resulted in increased comet parameters indicating DNA damage of tumor cells. Histopathological examination revealed a significant decrease in a number of neoplastic cells within tumor of mice that treated with Se. In conclusion, these findings suggest that Se therapy significantly suppressed solid tumor proliferation and growth while mitigating the health status of tumor‐bearing mice.
Impaired coenzyme A homeostasis in cardiac dysfunction and benefits of boosting coenzyme A production with vitamin B5 and its derivatives in the management of heart failure
Authors: Wedman J. J. , Sibon O. C. M. , Mastantuono E. , Iuso A. 
Published: April 2024

AbstractCoenzyme A (CoA) is an essential cofactor required for over a hundred metabolic reactions in the human body. This cofactor is synthesized de novo in our cells from vitamin B5, also known as pantothenic acid, a water‐soluble vitamin abundantly present in vegetables and animal‐based foods. Neurodegenerative disorders, cancer, and infectious diseases have been linked to defects in de novo CoA biosynthesis or reduced levels of this coenzyme. There is now accumulating evidence that CoA limitation is a critical pathomechanism in cardiac dysfunction too. In the current review, we will summarize our current knowledge on CoA and heart failure, with emphasis on two primary cardiomyopathies, phosphopantothenoylcysteine synthetase and phosphopantothenoylcysteine decarboxylase deficiency disorders biochemically characterized by a decreased level of CoA in patients' samples. Hence, we will discuss the potential benefits of CoA restoration in these diseases and, more generally, in heart failure, by vitamin B5 and its derivatives pantethine and 4′‐phosphopantetheine.
Multiparametric Aging Study Across Adulthood in the Leg Through Quantitative MR Imaging, 1H Spectroscopy, and 31P Spectroscopy at 3T
Authors: Lopez Kolkovsky Alfredo L. , Matot Beatrice , Baudin Pierre‐Yves , Caldas de Almeida Araujo Ericky , Reyngoudt Harmen , Marty Benjamin , Fromes Yves 
Published: April 2024

BackgroundImproved characterization of healthy muscle aging is needed to establish early biomarkers in age‐related diseases.PurposeTo quantify age‐related changes on multiple MRI and clinical variables evaluated in the same cohort and identify correlations among them.Study TypeProspective.Population70 healthy subjects (30 men) from 20 to 81 years old.Field Strength/Sequence3T/water T2 (multiecho SE, multi‐TE STEAM), water T1 (GRE MR Fingerprinting), fat‐fraction (multiecho GRE, multi‐TE STEAM), carnosine (PRESS), multicomponent water T2 (ISIS‐CPMG SE train), and 31P pulse‐acquire spectroscopy.AssessmentAge‐ and sex‐related changes on:
Imaging: fat‐fraction (FFMRI), water T1 (T1‐H2O), and T2 (T2‐H2O‐MRI) and their heterogeneities ΔT1‐H2O and ΔT2‐H2O‐MRI in the posterior compartment (PC) and anterior compartment (AC) of the leg.
1H spectroscopy: Carnosine concentration, pH, water T2 components (T2‐H2O‐CPMG), fat‐fraction (FFMRS), and water T2 (T2‐H2O‐MRS) in the gastrocnemius medialis.
31P spectroscopy: Phosphodiesters (PDE), phosphomonoesters, inorganic phosphates (Pi), and phosphocreatine (PCr) normalized to adenosine triphosphate (ATP) and pH in the calf.
Clinical evaluation: Body‐mass index (BMI), gait speed (GS), plantar flexion strength, handgrip strength (HS), HS normalized to wrist circumference (HSnorm), physical activity assessment.
Statistical TestsMultilinear regressions with sex and age as fixed factors. Spearman correlations calculated between variables. Benjamini–Hochberg procedure for false positives reduction (5% rate). A P < 0.05 significance level was used.ResultsSignificant age‐related increases were found for BMI (ρAge = 0.04), HSnorm (ρAge = −0.01), PDE/ATP (ρAge = 2.8 × 10−3), Pi/ATP (ρAge = 2.0 × 10−3), Pi/PCr (ρAge = 0.3 × 10−3), T2‐H2O‐MRS (ρAge = 0.051 msec), FFMRS (ρAge = 0.036) the intermediate T2‐H2O‐CPMG component time (ρAge = 0.112 msec), and fraction (ρAge = −0.3 × 10−3); and in both compartments for FFMRI (ρAge = 0.06, PC; ρAge = 0.06, AC), T2‐H2O‐MRI (ρAge = 0.05, PC; ρAge = 0.05, AC; msec), ΔT2‐H2O‐MRI (ρAge = 0.02, PC; ρAge = 0.02, AC; msec), T1‐H2O (ρAge = 1.08, PC; ρAge = 1.06, AC; msec), and ΔT1‐H2O (ρAge = 0.22, PC; ρAge = 0.37, AC; msec). The best age predictors, accounting for sex‐related differences, were HSnorm (R2 = 0.52) and PDE/ATP (R2 = 0.44). In both leg compartments, the imaging measures and HSnorm were intercorrelated. In PC, T2‐H2O‐MRS and FFMRS also showed numerous correlations to the imaging measures. PDE/ATP correlated to T1‐H2O, T2‐H2O‐MRI, ΔT2‐H2O‐MRI, FFMRI, FFMRS, the intermediate T2‐H2O‐CPMG, BMI, Pi/PCr, and HSnorm.Data ConclusionOur multiparametric MRI approach provided an integrative view of age‐related changes in the leg and revealed multiple correlations between these parameters and the normalized HS.Level of Evidence1Technical EfficacyStage 3
Does jasmonic acid mitigate the adverse effects of salt stress on wheat through the enhancement of ascorbate biosynthesis and the induction of glutamate dehydrogenase activity?
Authors: Horchani Faouzi , Bouallegue Amal , Abbes Zouhaier 
Published: April 2024

AbstractBackgroundSalt stress is one of the most common abiotic stresses, reducing plant growth and productivity. Thus, the development of suitable management practices to minimize the deleterious effects of salt stress has become necessary.AimsThis study was conducted to investigate the possible mechanisms underlying salt tolerance conferred by jasmonic acid (JA).MethodsSalt‐stressed wheat seedlings were supplemented with 1 mM JA and/or 1 mM ibuprofen (IBU), an inhibitor of endogenous JA biosynthesis, in the culture medium.ResultsThe obtained results showed that salt stress significantly decreased shoot and root dry weight production and relative water contents. This was associated with a noteworthy reduction in leaf and root ascorbate (AsA) concentrations, as well as glutamine synthetase (GS), glutamate synthase (GOGAT), and glutamate dehydrogenase (GDH) activities. Exogenously supplied JA did not affect GS and GOGAT activities in leaves and roots of salt‐treated seedlings. However, noticeable enhancements were observed in growth, AsA concentrations, as well as GDH activities. Likewise, the inhibition of JA biosynthesis by IBU application was accompanied by a significant decrease in seedlings’ growth associated with a noticeable reduction in AsA concentrations and GDH activities. The decreases in growth and GDH activities were also obtained following inhibition of AsA biosynthesis by lycorine (Lyc) application. By contrast, increased GDH activities and enhanced growth were obtained following exogenous AsA supplementation, with or without JA biosynthesis inhibition.ConclusionsThe findings implied that exogenous JA enhanced AsA biosynthesis and induced GDH activity, which further promoted the growth of wheat seedlings in salt‐stressed conditions. Therefore, the stimulation of AsA biosynthesis and GDH activity through JA application in the rhizosphere may be suggested as a vital strategy for strengthening the salt tolerance of wheat plants, at least at the seedling stage.
Anti‐aging effect of peptides on Caenorhabditis elegans: a meta‐analysis
Authors: Huang Chao , Zhu Ling , Zhang Hui , Liu Tongtong , Wang Li , Wu Gangcheng 
Published: April 2024

AbstractBACKGROUNDRecently, peptides have been studied in Caenorhabditis elegans for anti‐aging research. Due to the lack of sufficient evidence, we conducted this meta‐analysis focusing on the anti‐aging effect of peptides in C. elegans to provide more convincing evidence.RESULTSA literature search in PubMed, SCOUPUS, and Web of Science databases yielded 2879 articles. After removing duplicates and based on inclusion criteria and STAIR checklist quality assessment, nine articles were selected. Data extraction and analysis showed that, compared to the control group without peptide intervention, peptide supplementation significantly reduced nematode mortality risk [hazard ratio = 0.54, 95% confidence interval (CI) = 0.47, 0.62; P < 0.05], significantly increased the pharyngeal pumping rate [standardized mean difference (SMD) = 1.64, 95% CI = 0.87, 2.41; P < 0.05], bending frequency (SMD = 1.67, 95% CI = 1.16, 2.18; P < 0.05), and significantly decreased the accumulation of lipofuscin levels within nematodes (SMD = −4.48, 95% CI = −6.85, −2.12; P < 0.05). Additionally, subgroup analysis showed that doses ranging from 0.1 to 1 mg/mL (HR = 0.50, 95% CI = 0.38, 0.65; P < 0.05) displayed better anti‐aging effects compared to other dose ranges.CONCLUSIONThe findings suggest that peptides can significantly extend the lifespan of C. elegans under normal circumstances and improve three indicators of healthy life. More importantly, subgroup analysis revealed that a dosage of 0.1–1 mg/mL demonstrated superior anti‐aging effects. This meta‐analysis provides more convincing evidence that peptides can play an anti‐aging role in C. elegans. © 2024 Society of Chemical Industry.
Enhancing precision in osteochondral lesions of the talus measurements and improving agreement in surgical decision‐making using weight‐bearing computed tomography and distance mapping
Authors: Efrima Ben , Dahmen Jari , Barbero Agustin , Benady Amit , Maccario Camilla , Indino Cristian , Kerkhoffs Gino , Usuelli Federico Giuseppe 
Published: April 2024

AbstractPurposeWeight‐bearing computed tomography (WBCT) enables the creation of a three‐dimensional (3D) model that represents the ankle morphology in a standing position. Distance mapping (DM) is a complementary feature that uses color coding to represent the relative intraarticular distance and can be used to outline intraarticular defects. Consequently, DM offers a novel approach to delineating osteochondral lesions of the talus (OLT), allowing for the quantification of its surface, volume and depth. The reliability of DM for OLT measurements has yet to be thoroughly evaluated. This study primarily aims to determine the reliability of DM in measuring the surface, depth and volume of OLT. A secondary objective is to ascertain whether measurements obtained through DM, when integrated with a predefined treatment algorithm, can facilitate consensus among surgeons regarding the optimal surgical intervention.MethodsThis cohort comprised 36 patients with 40 OLTs evaluated using WBCT and DM. Two raters used DM to determine the lesion boundary (LB) and lesion fundus (LF) and calculate the lesion depth, surface and volume. The raters were asked to choose between bone marrow stimulation, autologous matrix‐induced chondrogenesis and osteochondral transposition based on the measurement. Inter‐rater and intra‐rater agreement was measured.ResultsInterclass correlation of the lesion's depth surface produced an excellent inter‐rater and intra‐rater agreement of 0.90–0.94 p < 0.001. Cohen's κ agreement analysis of the preferable preoperative plan produced a κ = 0.834, p < 0.001, indicating a near‐perfect agreement.ConclusionWBCT‐based 3D modules and DM can be used to measure the lesion's surface, depth and volume with excellent inter‐rater and inter‐rater agreement; using this measurement and a predetermined treatment algorithm, a near‐perfect inter‐rater agreement for the preoperative planning was reached. WBCT in conjunction with AI capabilities could help determine the type of surgery needed preoperatively, evaluate the hindfoot alignment and assess if additional surgeries are needed.Level of EvidenceLevel III.
Key developments in global scholarly publishing: Negotiating a double‐edged sword
Authors: Oparinde Kunle , Govender Vaneshree , Adedokun Theophilus , Agbede Grace Temiloluwa , Thungo Sithabile 
Published: April 2024

AbstractOver the last few years, the publishing industry has experienced significant changes and developments, most of which have had a positive influence on scholarly publishing. For instance, the gradual popularity of open access publishing has contributed to the wider access and readership of published materials. Also, the recent development in the abilities of artificial intelligence (AI) tools to assist in the publication process is laudable for its potential. The gradual shift from print to online publication is also a commendable development in global publishing. Not without their own challenges, these developments, among others, have mostly impacted global publishing in a positive way. In the current study, the researchers' argument stems from the notion that although these developments are invaluable, there are accompanying impediments that publishing professionals as well as publishing outlets must consider. In response to these developments, role‐players in the publishing industry must constantly reassess their publishing processes in order to carefully manage and negotiate what is termed by this study as a ‘double‐edged sword’ (capable of having positive and negative consequences). This study reviews existing studies, draws views from publishing experts, and seeks opinions from scholars to establish methods of negotiating some of the key developments in global publishing.