bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metabolite Formation of Pesticide Isoprocarb in Coffee Beans During Short-Term Storage and Condition
Authors: Nainggolan Rosaria , Saefumillah Asep , Saefudin Endang , Putra Yanwar Pratama 
Published: April 2024

Isoprocarb (IPC) is one of the most important carbamate pesticides for white flea control in coffee plants. The prevalence of isoprocarb pesticide residues in coffee, i.e., green coffee beans, is a cause for concern. Green coffee beans were intentionally contaminated with isoprocarb at concentrations >0.01 mg/kg, which was investigated in this research. Quantitative analysis of isoprocarb with the QuEChERS method and qualitative analysis for metabolite formation was characterized using UV-Vis, FTIR, 1H-NMR, GC-MS, and LC-QTOF-MS. Based on the data, the metabolite formed is o-cumenol through the hydrolysis reaction of o-aryl carbamate with the enzyme carboxylesterase. o-cumenol or 2- isopropylphenol as a phenol derivative. To verify the existence of metabolite analytes that are believed to be there in coffee tainted with isoprocarb, more reliable analytical techniques utilizing analytical standards must be developed. Isoprocarb concentrations decreased along the storage time, especially in unsterilized conditions. As a toxic compound, a quantitative structural activity relationship study (QSAR) was initially carried out through a software application for estimating toxicity (TEST) provided by the US Environmental Protection Agency (EPA). For additional information, based on the LC50 and LD50 data confirmed from the TEST application, it was concluded that isoprocarb is more toxic than o-cumenol.
Assessing the recycling potential of thermosetting polymer waste in high-density polyethylene composites for safety helmet applications
Authors: Periasamy Diwahar , Karuppiah Prakalathan , Manoharan Bharathi , Arockiasamy Felix Sahayaraj , Kannan Sathish , Mohanavel Vinayagam , Velmurugan Palanivel , Arumugam Natarajan , Almansour Abdulrahman I. , Sivakumar Subpiramaniyam 
Published: April 2024

Abstract
The rising demand for thermosetting polymers has resulted in the production of large amounts of industrial waste. Environmental issues due to waste landfills and increased raw material costs for new product development have led to the development of innovative recycling methods. This study focuses on the development of a product (helmet shell) by reinforcing thermosetting polymer waste (TPW) as a filler in a high-density polyethylene (HDPE) matrix. The HDPE and TPW were converted into extrudates using a twin-screw extruder. Then, the extrudate was pelletized to use as raw material for the injection molding machine. The HDPE/TPW composites were fabricated using injection molding. Maleic anhydride-grafted polyethylene was employed as a compatibilizer. In the composite, the TPW volume was reinforced at various weight percentages, ranging from 0 to 35 wt%. The mechanical, thermal, and viscoelastic properties of the composites can be enhanced by uniformly dispersing TPW in the HDPE matrix. However, it is difficult to achieve uniform dispersion at higher TPW volumes owing to the agglomeration effect. According to these findings, the mechanical properties were enhanced by up to 30 wt% addition of TPW. The findings suggest that the proposed composite has sufficient mechanical properties to be suitable for the fabrication of helmet shells.
Crystal structure of ethyl 2-(3-benzyl-4-oxo-3,4-dihydrophthalazin-1-yl)- 2,2-difluoroacetate, C19H16F2N2O3
Authors: Huang Rong , Yao Zhen , Zhou Ying 
Published: April 2024

Abstract
C19H16F2
N
2O3, monoclinic, P21/c (no. 14), a = 17.5688(15) Å, b = 13.8304(11) Å, c = 7.0600(7) Å, β = 100.254(3)∘, V = 1688.1(3) Å3, Z = 4, R

gt
(F) = 0.0516, wR

ref
(F2) = 0.1424, T = 200(2) K.
Selective peripheral tissue response to high testosterone levels in an infertile woman without virilization signs
Authors: Ostrovsky Viviana , Ulman Mira , Hemi Rina , Lurie Samuel , Hazan Inon , Ben Ari Alon , Sukmanov Oleg , Schiller Tal , Kirzhner Alena , Zornitzki Taiba 
Published: April 2024

Summary
Total testosterone, which is peripherally converted to its biologically active form dihydrotestosterone (DHT), is the first-line hormone investigation in hyperandrogenic states and infertility in premenopausal women. Polycystic ovary syndrome (PCOS), the most common cause of hyperandrogenism and infertility in young women, is often associated with mild elevations of total testosterone. Whereas very high levels of total testosterone (>2–3 SD of normal reference), are most often associated with hyperandrogenic signs, menstrual irregularity, rapid onset of virilization, and demand a prompt investigation. Herein, we report a case of a 32-year-old woman who was referred to the endocrinology outpatient clinic due to secondary amenorrhea and extremely high testosterone levels without any virilization signs. We initially suspected pitfalls in the testosterone laboratory test. Total serum testosterone decreased after a diethyl-ether extraction procedure was done prior to the immunoassay, but testosterone levels were still elevated. An ovarian steroid-cell tumor (SCT) was then revealed, which was thereby resected. Twenty-four hours post surgery, the total testosterone level returned to normal, and a month later menstruation resumed. This case emphasizes that any discrepancy between laboratory tests and the clinical scenario deserves a rigorous evaluation to minimize misinterpretation and errors in diagnosis and therapeutic approach. Additionally, we describe a possible mechanism of disease: a selective peripheral target-tissue response to high testosterone levels that did not cause virilization but did suppress ovulation and menstruation.

Learning points

Total testosterone is the most clinically relevant hormone in investigating hyperandrogenic states and infertility in premenopausal women.

Very high total testosterone levels in women (>2–3 SD of normal reference) are most often associated with hyperandrogenic signs, menstrual irregularities, and a rapid onset of virilization.

In women with very elevated testosterone levels and the absence of clinical manifestations, laboratory interference should be suspected, and diethyl ether extraction is a useful technique when other methods fail to detect it.

Ovarian steroid cell tumors (SCT) encompass a rare subgroup of sex cord-stromal tumors and usually secrete androgen hormones. SCTs are clinically malignant in 25–43% of cases.

A selective response of peripheral target tissues to testosterone levels, with clinical manifestations in some tissues and no expression in others, may reflect differences in the conformation of tumor-produced testosterone molecules.
Association of Very Low Birth Weight Infants With Parental and Sibling Mental Health Care Usage
Authors: Schwartz Katherine E. , Nye Russell T. , Colt Susannah , Hill Douglas L. , Feudtner Chris 
Published: April 2024

BACKGROUND AND OBJECTIVES
Parents and siblings of very low birth weight, premature infants are at risk for poor mental health outcomes with increased mental health care usage. Knowledge regarding mental health care use patterns could guide interventions.

METHODS
This retrospective cohort study included US families with commercial insurance coverage from a single carrier. Neonates born at ≤30 weeks’ gestational age or with a birth weight &lt;1500 g were identified by insurance claim data between July 1, 2015, and June 30, 2016. Each case neonate family was matched with up to 4 control families.

RESULTS
The study included 1209 case and 1884 control neonates (with 134 deaths among only the case neonates [11.1% of cases]); 2003 case and 3336 control parents (mean [SD] age, 34.6 [5.4] years; 2858 [53.5%] female); and 884 case and 1878 control siblings (mean [SD] age, 6.8 [5.5] years; 1375 [49.8%] female). Compared with controls, more case parents used mental health care over the first year after birth hospitalization discharge. Higher usage was observed for bereaved case parents soon after their child’s death. A smaller proportion of bereaved case siblings received mental health care compared with controls. Although nonbereaved case parents returned toward the proportion of use observed in controls, nonbereaved case female siblings, bereaved case female and male siblings, and bereaved male parents experienced continued differences.

CONCLUSIONS
Understanding and meeting the mental health care needs of parents and siblings of very low birth weight premature neonates can be guided by these findings, including elevated and prolonged needs of bereaved parents and siblings.
EPIDEMIOLOGÍA DE LAS ANOMALÍAS CONGÉNITAS EN UN HOSPITAL DE REFERENCIA NACIONAL EN ECUADOR
Authors: Toapanta-Pinta Paola , Vasco-Toapanta Cristhian , Sidel-Almache Kevin , Salinas-Salinas Analy Alejandra , Vasco-Morales Santiago 
Published: April 2024

Objetivo. Determinar la prevalencia, tipos y factores de riesgo asociados a anomalías congénitas en recién nacidos ingresados en el Hospital Gineco-Obstétrico Isidro Ayora de Quito, Ecuador, entre 2009-2022.
Métodos. Estudio transversal, con datos retrospectivos de la base de datos del Sistema Informático Perinatal. Se emplearon pruebas de Chi cuadrado y modelos de regresión logística binaria simples y múltiples. Se utilizó el lenguaje de programación R.
Resultados. Se estudiaron 26 236 recién nacidos, el 11,7% (3 075) fueron diagnosticados con anomalías congénitas. Las más frecuentes fueron las relacionadas con el sistema nervioso (25,6%), las cardiorrespiratorias (21,1%) y las musculoesqueléticas (16,1%). La edad materna superior a 35 años, la planificación del embarazo y los embarazos múltiples se asociaron con la presencia de anomalías congénitas. Al analizar los factores de riesgo en función del sistema afectado se encontró que la edad materna, los antecedentes maternos de abortos y diabetes, el consumo de ácido fólico y el sexo del recién nacido tenían efectos tanto favorables como desfavorables para el desarrollo de anomalías congénitas de un sistema específico.
Conclusiones. Este estudio investigó la prevalencia y los tipos más comunes de anomalías congénitas, así como sus factores de riesgo asociados, en un hospital de referencia. Se compararon estos hallazgos con lo reportado en otras regiones. Los resultados obtenidos ofrecen datos significativos sobre la epidemiología de las anomalías congénitas en la población estudiada, lo que puede orientar el desarrollo de estrategias preventivas. Se destaca la necesidad de realizar investigaciones más exhaustivas sobre este tema en la región.
The Prevalence of Root Resorption in a Sample of Orthodontic Patients Treated in Private Clinics in Sulaimani City/ A Retrospective Study
Authors: Omer Sana , Abdulrahman Adham 
Published: April 2024

Objective: Root resorption is an inevitable consequence of orthodontic treatment. This retrospective study aimed to determine theprevalence of root resorption secondary to orthodontic treatment in private clinics in Sulaimani City, Iraq and to compare the difference in the amount of root resorption between varying teeth, regions of the mouth, and the upper and lower arches in order to lessen or eliminate unsolicited and undue impediments.
Methods: Among the 465 cases with available data, treated in private clinics of the participating practitioners, only 92 were fullyeligible for study. Pre-operative lateral cephalograms were measured using Eastman Analysis on WebCeph. A customized frame wascreated on AutoCAD and pre and post-operative orthopantomograms were measured for root resorption only if they fitted into theframe. Intra and inter-observer reliability were performed to ensure optimal accuracy in the measurements. The millimetermeasurements of root resorption were converted into percentages to identify the prevalence of root resorption in Sulaimani City.
Results: The root resorption in the different individual teeth resulted in a significant relationship with orthodontic treatment. Factorssuch as age, gender, and duration of treatment were not significantly associated with root resorption. The results of the upper and lower arches indicated no significant differences between the arches. The incisors showed more significant resorption when compared to canines.
Conclusions: Orthodontic treatment affects the prevalence and severity of root resorption. Age, gender, and duration of treatment have no significant relation with apical root resorption. Different regions of the mouth encounter varying degrees of apical root resorption. Even in the anterior teeth, incisors are more prone to resorption than canines.
Мотивация достижения как необходимый фактор успешного развития студентов в образовательной среде вуза
Authors: Vlasova I.V. 
Published: April 2024

The question of motivation of university students as a psychological and pedagogical problem is considered, various types of motivation characteristic of educational activities in a university, some classifications of motives for educational activities of domestic and foreign scientists are given. It is concluded that the issue of increasing the level of motivation of students in a higher educational institution should be given close attention, since modern society needs specialists with a high level of professionalism, entrepreneurship, initiative, creativity and creative abilities. For successful development in the educational environment of the university, achievement motivation, a purposeful pursuit of knowledge, complemented by responsibility for one’s own development, adequate self-esteem and assessment of one’s capabilities are important.
Рассматривается вопрос мотивации студентов вуза как психолого-педагогическая проблема, различные виды мотивации, характерные для учебной деятельности в вузе, приведены некоторые классификации мотивов учебной деятельности отечественных и зарубежных ученых. Делается вывод о том, что вопросу повышения уровня мотивации студентов в высшем учебном заведении необходимо уделять пристальное внимание, так как современному обществу нужны специалисты с высоким уровнем профессионализма, предприимчивости, инициативности, креативности и творческих способностей. Для успешного развития в образовательной среде вуза важна мотивация достижения, целенаправленное стремление к знаниям, дополненное ответственностью за свое развитие, адекватной самооценкой и оценкой своих возможностей.
The Main Directions of Organizing Project Activities as an Effective Mechanism for Developing Professional Competencies and Improving the Quality of Professional Training
Authors: Гаранина Р.М. 
Published: April 2024

Рассмотрены основные аспекты проектной деятельности студентов как перспективного способа и одновременно условия формирования компетенций. Отмечается, что профессиональная подготовка на основе проектной деятельности позволяет обучающимся развивать самостоятельность мышления, познавательные навыки, вырабатывать инновационные подходы к решению организационных и управленческих проблем. Обоснован выбор методологических подходов и методов, которые позволили продолжить изучение феномена проектной деятельности. Описаны возможности совершенствования наработок передовых педагогических коллективов, дополнения новыми креативными элементами идей проектной деятельности. Сделаны выводы о важности достигаемых в процессе проектной деятельности образовательных результатов, значимости как индивидуального вклада студента, так и сотрудничества преподавателей и обучающихся.
The main aspects of students’ project activities are considered as a promising method and at the same time the conditions for the formation of competencies. It is noted that professional training based on project activities allows students to develop independent thinking, cognitive skills, and develop innovative approaches to solving organizational and management problems. The choice of methodological approaches and methods that made it possible to continue the study of the phenomenon of project activity is justified. The possibilities of improving the developments of advanced teaching teams and adding new creative elements to the ideas of project activities are described. Conclusions are drawn about the importance of the educational results achieved in the process of project activities, the significance of both the individual contribution of the student and the cooperation of teachers and students.
Death due to early pulmonary thromboembolism following tibial fracture: A case report
Authors: Nishanth V.S  , Moses T. Mohit Kumar , Tadi Shipra , Kasireddi Bharathi Devi , Mandala Mahesh , Rupesh Kattamreddy Ananth 
Published: April 2024

Pulmonary Thrombo Embolism (PTE) is primarily attributed to venous thromboembolism, resulting in the obstruction of pulmonary arteries by a thrombus that impedes blood flow to the lungs. The thrombus typically gets lodged at the bifurcation of the main pulmonary artery or the lobar branches, leading to hemodynamic compromise. While the origin of the thrombus is commonly traced back to the lower extremities (Deep Vein Thrombosis, DVT), in rare instances, it may arise from the pelvis, renal veins, upper extremity veins, or right side of the heart. Various factors can contribute to the development of deep vein thrombosis, but in the context of long bone fractures, it is predominantly associated with prolonged immobilization. The typical time frame for DVT to manifest after the injury is 7 to 10 days. However, there have been infrequent cases where PTE has developed within 72 hours of the injury. Several theories have been proposed to elucidate the early onset of PTE in such cases.This report presents a case of early pulmonary thromboembolism in a tibial fracture, as observed during the autopsy examination of a 22-year-old male who succumbed to injuries sustained in a road traffic accident within 6 hours of the incident. Subsequent histopathological analysis following the autopsy revealed the presence of a thrombus in the pulmonary artery.
Prevalence of early childhood caries post covid-19 pandemic in Mumbai among children aged 3-5 years: A cross-sectional pilot study
Authors: Jagtap Vijaya , Padawe Dimple , Takate Vilas 
Published: April 2024

This cross-sectional pilot study aims to investigate the prevalence of Early Childhood Caries (ECC) among children aged 3 to 5 years in Mumbai City, Maharashtra, following the COVID-19 pandemic. A total of 91 children were included in the study, with ECC prevalence assessed through standardized examinations and dmfs scoring. Simple random sampling was employed, and data were analyzed using descriptive statistics and inferential tests. The study found a high prevalence of ECC (63.74%) among the study population, with no significant gender-based differences observed in ECC occurrence or severity. Despite similar ECC prevalence rates between boys and girls, the overall burden of ECC underscores the urgent need for targeted interventions and preventive measures. The findings highlight the pressing oral health challenge faced by young children in urban settings post-pandemic and emphasize the importance of comprehensive oral health promotion programs and equitable access to preventive oral healthcare. Addressing modifiable risk factors and integrating oral health services into primary healthcare systems are essential steps toward improving oral health outcomes for children in Mumbai and similar urban environments.
TECNOLOGIAS DA INFORMAÇÃO E COMUNICAÇÃO: EDUCAÇÃO EM SAÚDE E EDUCAÇÃO PERMANENTE VOLTADAS À COVID-19
Authors: Vargas da Costa Anna Karoline , Azevedo da Silva Karem , Miollo Gisele , Schimith Maria Denise , Oliveira Gabriela , Wickert Daiana Cristina , De Lemos Mello Amanda 
Published: April 2024

Objetivo: relatar a experiência de um Programa de Extensão no desenvolvimento de ações de Educação em Saúde e Educação Permanente em Saúde voltadas à COVID-19, utilizando Tecnologias da Informação e Comunicação. Método: relato de experiência de docentes, discentes de graduação e pós-graduação acerca do desenvolvimento de um Programa de Extensão de uma Instituição de Ensino Superior pública localizada no Rio Grande do Sul. Resultados: foram produzidos e compartilhados nas plataformas digitais seis Produtos Técnicos e Tecnológicos audiovisuais, sendo que quatro abordaram medidas e orientações de educação em saúde e dois orientações para a Rede de Atenção Primária à Saúde de diferentes municípios. Ainda, foram elaborados e implementados dois infográficos destinados aos profissionais das Unidades de Atenção Primária à Saúde de Santa Maria. Considerações finais: o programa possibilitou articular ensino, pesquisa e extensão, contribuindo para a difusão do conhecimento como veículo de transformação social frente à pandemia da COVID-19.
Descritores: COVID-19; Educação em Saúde; Educação Continuada; Enfermagem; Tecnologia da Informação.
LITERATURE REVIEW : ANALYSIS OF PHYSICAL CONDITION REQUIREMENTS IN SEATED VOLLEYBALL GAMES
Authors: Setiyawan Andri Asrul , Hidayatullah Muhammad Furqon 
Published: April 2024

ABSTRCT
This literature review aims to determine several aspects of the physical condition requirements in sitting volleyball games. The method used is literature observation from three electronic databases including Google Scholar, PubMed, and ScienceDirect. This study is based on an examination of 5 studies published between 2013 and 2023 using the SPIDER or Sample, Phenomenon of Interest, Design, Evaluation, and Research type analysis types. The sample used in the reviewed article is elite seated volleyball athletes in their country. The results of the literature review of the 5 articles used in this literature insight show that aspects of physical condition in the sitting volleyball game are very much needed, especially in the upper body and in the training process you must pay attention to various aspects including gender, identification of injuries and type of classification, namely VS1 ( heavy) and VS2 (light). The conclusion from this literature review is that regularly programmed and organized management of physical condition aspects can improve the ability to play seated volleyball in athletes with disabilities.
Keywords: physical condition and sitting volleyball