bluuebunny/crossref_metadata_2025_split huggingface dataset:
“The 10th International MDM2 Workshop”: Opening up new avenues for MDM2 and p53 research, the First International MDM2 Workshop in Asia
Authors: Ohki Rieko , Itahana Koji , Iwakuma Tomoo 
Published: March 2024

AbstractThe 10th International MDM2 Workshop was held at the National Cancer Center Research Institute (NCCRI) in Tokyo, Japan, from October 15 to 18, 2023. It attracted 166 participants from 12 countries. The meeting featured 52 talks and 41 poster presentations. In the first special session, six invited speakers gave educational and outstanding talks on breakthroughs in MDM2 research. Three keynote speakers presented emerging p53‐independent functions of MDM2/MDM4, functional association of MDM2/p53 with cancer immunity, and drug discovery targeting the MDM2/MDM4‐p53 pathway. Additionally, 19 invited speakers introduced their new findings. Twenty‐one presenters, many of whom were young investigators, postdocs, and students, were selected from submitted abstracts and reported their exciting and unpublished results. For poster presenters, outstanding poster awards were given to the best presenters. There were many inspiring questions and discussions throughout the meeting. Social events like a welcome party, a workshop dinner, and an optional tour enabled further scientific interactions among the participants. The meeting successfully provided an exciting platform for scientific exchange. The experience gained from organizing this meeting will be handed over to the next organizers of the 11th International MDM2 Workshop.
Using infographics in disseminating healthy lifestyle information on social media is likely to increase uptake and sharing
Authors: Chu Sin Ting , Chiu Dickson K. W. , Ho Kevin K. W. 
Published: March 2024

AbstractBackgroundInfographics facilitate rapid information dissemination with enriched eye‐catching content on social media, but it is unclear what factors affect the adoption of information presented in this way.ObjectivesWe tested whether the Information Acceptance Model applies to infographics on healthy lifestyle and fitness topics.MethodsTwo hundred and four university students were invited to participate in an online survey on their acceptance after reading some healthy lifestyle and fitness topics infographics shared on social media. The data collected were analysed using Partial Least Square path modelling.ResultsThe results confirmed information usefulness as a predictor of information adoption; attitude towards information and information adoption were the predictors of behavioural intention. Information credibility and attitude towards information, but not information quality and needs, were significantly related to information usefulness. Social media usage and education level were factors affecting infographics impressions.DiscussionResults support most hypotheses. It confirms information usefulness as a predictor of infographics adoption. Attitudes towards information and information adoption are predictors of behavioural intentions of following healthy lifestyle and fitness suggestions through social media infographics.ConclusionSocial media facilitates interpersonal communication, information exchange and knowledge sharing, and infographics may draw people into healthy lifestyle and fitness information items relevant to them.
Fabrication, microstructure, and mechanical properties of novel three‐layer structured bionic ceramic cutting tools
Authors: Li Shijie , Huang Chuanzhen , Liu Hanlian , Shi Zhenyu , Ji Lianggang , Cui Xinyao , Du Chongzhen , Wang Zhen , Xu Longhua , Huang Shuiquan 
Published: March 2024

AbstractCeramic cutting tools have low fracture toughness owing to brittleness. To improve the fracture toughness and flexural strength of ceramic cutting tools, the growth model of SiCw during the sintering process was established by the laminated structure and anisotropy of growth of bionic shells. Furthermore, a theoretical model of sintering parameters and total fracture toughness was achieved. Then, the dispersion process of SiCw was improved to enhance the homogeneity of the mixed powders further. Finally, a novel three‐layer structured bionic ceramic cutting tool was fabricated by hot‐pressing. The effects of sintering temperature, holding time, and sintering pressure on the mechanical properties and microstructure of bionic ceramic cutting tools were investigated. The results showed that the flexural strength (three point bending), fracture toughness (indentation method), and Vickers hardness of the three‐layer structured bionic ceramic cutting tool with excellent dispersed were 735 ± 34 MPa, 5.68 ± 0.06 MPa·m1/2, and 19.66 ± 0.12 GPa, respectively. The microstructure of the fracture revealed that the fracture mechanism of the bionic ceramic cutting tool was a mixture of intergranular fracture, transgranular fracture, whisker pull‐out, whisker fracture, forked crack, crack deflection, crack bridging, zig‐zag crack, and crack termination. The accuracy of the total fracture toughness model was reliable.
Environmental drivers of wheat yield variability across China's production regions: Insights from field experiments
Authors: Zheng Dongxiao , Zhou Yang , Harrison Matthew Tom , Zhou Meixue , Xiong Dongliang , Deng Nanyan , Wang Fei , Ling Xiaoxia , Nie Lixiao , Huang Jianliang , Peng Shaobing , Liu Ke , Man Jianguo 
Published: March 2024

AbstractWheat crops underpin contemporary global food security. Predominant wheat production zones in China include the Huang‐Huai‐Hai‐Plain and the Mid‐Lower Reaches of the Yangtze River, although climatic effects on productive potential across these regions vary markedly in space and time. Here, we conducted field experiments during the wheat season of 2015–2018 to examine environmental effects on growth, with fertilization and irrigation provided at levels ensuring that nutrient and water stress exposure was minimal. Yields in Huang‐Huai‐Hai‐Plain and the Mid‐Lower Reaches of the Yangtze River averaged 8950 and 4818 kg ha−1, respectively. Yield variation across regions was primarily related to spike number per unit area and grain number per spike. Maturity biomass was higher in Huang‐Huai‐Hai‐Plain; this translated into higher grain yields. Lower temperature and longer growing duration between emergence and jointing in Huang‐Huai‐Hai‐Plain afforded higher tillering and spike numbers, whereas higher growth rates from jointing to maturity resulted in higher biomass production in Huang‐Huai‐Hai‐Plain compare with the Mid‐Lower Reaches of Yangtze River. Growth rate, grain numbers and yield were positively correlated with the ratio of daily intercepted solar radiation to mean temperature during jointing to anthesis, termed photothermal quotient. Collectively, our results suggest that growth rate accounted for more variation in biomass production compared with growth duration, and the photothermal conditions in the Mid‐Lower Reaches of the Yangtze River were restrictive for spike development and yield formation. Our results help disentangle drivers of crop growth through the development of agro‐environmental conceptual frameworks, enabling a better understanding of yield variability in space and time.
Impact of short‐notice accreditation assessments on hospitals' patient safety and quality culture—A scoping review
Authors: Scanlan Robyn , Flenady Tracy , Judd Jenni 
Published: March 2024

AbstractAimTo explore the published evidence describing the impact of short‐notice accreditation assessments on hospitals' patient safety and quality culture.DesignArksey and O'Malley (2005)'s scoping study framework and Preferred Reporting Items for Systematic Reviews and Meta‐Analysis Extension for Scoping reviews (PRISMA‐ScR).MethodsA scoping review was conducted to identify papers that provided an evaluation of short‐notice accreditation processes. All reviewers independently reviewed included papers and thematic analysis methods were used to understand the data.Data SourcesPubMed/MEDLINE, CINAHL, and ProQuest databases were searched to identify papers published after 2000.ResultsTotally, 3317 records were initially identified with 64 full‐text studies screened by the reviewers. Five studies were deemed to meet this scoping review's inclusion criteria. All five studies reported variable evidence on the validity of health service or hospital accreditation processes and only three considered the concept of patient safety and quality culture in the context of accreditation. None of the five included studies report the impact of a short‐notice accreditation process on a hospital's patient safety and quality culture.ConclusionsLimited evidence exists to report on the effectiveness of hospital short‐notice accreditation models. No study has been undertaken to understand the impact of short‐notice accreditation on patient safety and quality cultures within hospital settings.Implications for the Profession and/or Patient CareUnderstanding this topic will support improved hospital quality, safety, policy, and governance.ImpactTo provide an understanding of the current knowledge base of short‐notice accreditation models and its impact on hospital patient safety and quality culture.Reporting MethodsPRISMA reporting guidelines have been adhered to.Patient or Public ContributionNo patient or public contribution.
COVID‐19 and beyond: A systematic review of adaptations to psychosocial support in oncology
Authors: Martin Mahala , Rice Kylie , Murray Clara V. , Thorsteinsson Einar B. , Usher Kim J. 
Published: March 2024

AbstractAimsTo understand the strategies used to continue providing psychosocial support to cancer patients during the pandemic, including outcomes and implications beyond the pandemic.DesignA systematic review of original research.Data SourcesProQuest Health & Medicine, CINAHL Complete (via EBSCOhost), Scopus, and PubMed were searched for original work published between January 2020 and December 2022.MethodsAbstract and title screening identified eligible articles for full‐text review. Following a full‐text review, data were extracted from eligible articles, and a risk of bias assessment was conducted. A synthesis without meta‐analysis was performed.ResultsThirty‐four articles met the selection criteria. These articles provide evidence that systematic adaptations during the pandemic improved the assessment and screening of psychological needs and/or increased the number of clients accessing services. Additionally, while the pandemic was associated with decreased psychosocial well‐being for cancer patients, five intervention studies reported improvements in psychosocial well‐being. Barriers, strategies, and recommendations were described.ConclusionAdapting psychosocial support during a pandemic can be successful, achieved relatively quickly, and can increase the uptake of support for people experiencing cancer.Implications for Patient CareIt is imperative that these adaptations continue beyond the pandemic to maximize adaptive psychosocial outcomes for a group vulnerable to ongoing mental health concerns.ImpactWhile the COVID‐19 pandemic was associated with increased psychosocial need for cancer patients, evidence in the review suggested that adaptations made to service delivery facilitated increased access for patients who may not previously have been able to access support. Additionally, improvements in psychosocial well‐being were achieved. These findings are relevant for clinicians and decision‐makers who fund and design psychosocial support services for cancer patients.Reporting MethodThe review was guided by PRISMA Guidelines and the SWiM Reporting Guideline.Patient or Public ContributionNo patient or public contribution.
Triploid brown trout, Salmo trutta, develop functional gonads with age and are able to interbreed with diploid counterparts
Authors: Lahnsteiner Franz , Dünser Anna 
Published: March 2024

AbstractThe study investigated if gonad maturation in triploid brown trout, Salmo trutta, was entirely suppressed or only delayed, and if triploids could interbreed with diploid counterparts. Ten percent of the total number of 3‐year‐old triploid S. trutta, 15% of 4‐year‐old fish, and 17% of 5‐year‐old fish produced semen. Three and 4 years old triploid fish did not produce eggs, but 15% of the 5‐year‐old fish did so. The quantity and sperm motility of triploid semen did not differ from diploids, but the sperm concentration was significantly lower. When diploid eggs were fertilized with triploid semen (3n × 2n crosses), the percentage of eyed stage embryos, of hatched larvae, and of normal‐shaped larvae did not differ from the diploid controls. Circa 90% of 3n × 2n crosses had a ploidy level of 2.4n. In the remaining percentage of 3n × 2n crosses, the ploidy level was ≥2n and <2.4n. In sperm competition experiments where diploid eggs were fertilized with a mixture of diploid and triploid semen, 52% of the originating larvae had a ploidy level of 2n, 43% of 2.4n, and 5% of the fish were not exactly classified. From the start of feeding to an age of 248 days, the mortality rate of 3n × 2n interploid crosses and of 2n × 2n controls was similar. The growth of interploid crosses was significantly higher than that of controls. In triploid mature females, the egg mass per kilogram of body weight was significantly lower than in diploids. The mass of the non‐hardened eggs and the percentile weight increase during hardening did not differ from diploid eggs. When triploid eggs were fertilized with diploid semen (2n × 3n crosses), the development rate to normal hatched larvae was less than 10%. All originating larvae had a ploidy level of 3n. From the start of feeding to an age of 248 days, 2n × 3n crosses had a higher mortality rate (15%) than diploid controls (<5%). Growth of this type of interploid crosses was reduced in comparison to controls. Therefore, triploids introduced into natural waters for recreational fisheries or escaping from farms may interbreed with diploid counterparts. This not only alters the genotypes of local populations but also changes the ploidy levels.
Successful outcomes in juvenile justice: Overcoming community based and correctional challenges
Authors: Willingham Michelle L. 
Published: March 2024

AbstractThe juvenile justice system has long struggled with practices for understanding, preventing, and intervening in delinquency. Debates concerning youth delinquency, diversion efforts, and effective rehabilitation have consistently been examined. However, the answers to most of these fundamental approaches remain unresolved. Mental health is a major concern for juveniles under a correctional treatment program, but the juvenile justice system lacks individualized mental health services, having devastating and unfair results on youth in need. Through research, professional development, and advocacy, youth who are especially vulnerable to experiencing the undesired outcomes that result from receiving inadequate and inappropriate services will gain better outcomes.
Incarcerated youth and their siblings: A review of historical and current context, and future directions
Authors: Garza Micheal , Williams Claire 
Published: March 2024

AbstractThe 2020 Juvenile Residential Facility Census reports that roughly 25,000 youth in the United States (U.S.) are incarcerated—placing the United States as the leading nation in number of juveniles in correctional facilities worldwide. This paper aims to highlight an overlooked population impacted by this issue: not the incarcerated youth themselves, but their siblings. This paper first grounds historical trends, the effects of racialized sociopolitical systems on disparate rates of incarceration, and the current state of youth incarceration, with a specific focus on impacts on families. This paper reviews the literature on how families are affected by the juvenile justice system in terms of their well‐being, education, and other outcomes—drawing from the small body of research directly on siblings and hypothesizing impacts in need of further study based on families' experiences in the criminal justice system. We present historical and current issues/limitations to understanding and addressing the impacts of youth incarceration on siblings, concluding with areas of future research needed to address the impacts that a youth's incarceration has on their siblings and family.
Most of the escaped farmed salmon entering a river during a 5‐year period were infected with one or more viruses
Authors: Madhun Abdullah S. , Karlsbakk Egil , Skaala Øystein , Solberg Monica F. , Wennevik Vidar , Harvey Alison , Meier Sonnich , Fjeldheim Per T. , Andersen Kaja Christine , Glover Kevin A. 
Published: March 2024

AbstractDisease interactions between farmed and wild populations have been poorly documented for most aquaculture species, in part due to the complexities to study this. Here, we tested 567 farmed Atlantic salmon escapees, captured in a Norwegian river during 2014–2018, for five viral infections that are prevalent in global salmonid aquaculture. Over 90% of the escapees were infected with one or more viruses. Overall prevalences were: 75.7% for piscine orthoreovirus (PRV‐1), 43.6% for salmonid alphavirus (SAV), 31.2% for piscine myocarditis virus (PMCV), 1.2% for infectious pancreatic necrosis virus (IPNV) and 0.4% for salmon anaemia virus (ISAV). A significantly higher prevalence of PMCV infection was observed in immature compared to mature individuals. The prevalence of both SAV and PMCV infections was higher in fish determined by fatty acid profiling to be ‘recent’ as opposed to ‘early’ escapees that had been in the wild for a longer period of time. This is the first study to establish a time‐series of viral infection status of escapees entering a river with a native salmon population. Our results demonstrate that farmed escapees represent a continuous source of infectious agents which could potentially be transmitted to wild fish populations.
Influence of Food Security Status and Diet Quality on Maternal Gestational Weight Gain
Authors: Sparks Joshua R. , Myers Candice A. , Phelan Suzanne , Newton Robert L. , Yang Shengping , Redman Leanne M. 
Published: March 2024

BackgroundRecommended gestational weight gain (GWG) is crucial for health of women and their offspring. Food security status is hypothesized to influence diet quality and GWG. Therefore, we examined the relationship between diet quality and GWG by food security status.MethodsParticipants (n = 679) were enrolled in the Initial Vanguard Study of the National Children's Study. GWG was calculated as third trimester weight minus prepregnancy weight. Food security status and diet quality (Healthy Eating Index [HEI]‐2015) were assessed using the Household Food Security Survey and a Diet History Questionnaire, respectively. General linear models evaluated the relationship between GWG and HEI‐2015 by food security status.ResultsA greater proportion of women experienced food security (81.3%) compared with food insecurity (18.7%). In women with food security, GWG was negatively associated with HEI‐2015 in women having overweight (r = −0.421, P = .003) and positively associated with HEI‐2015 in women with inadequate GWG (r = 0.224, P = .019). Conversely, no significant relationships were found between GWG and HEI‐2015 in women with food insecurity.DiscussionImproved diet quality potentially lowers GWG in women with food security. However, in vulnerable populations, including women with food insecurity, improvements in diet quality may not effectively enhance GWG.
“The Anamorphic Journey”: Jean‐Luc Marion on Revelation
Authors: Hart Kevin 
Published: March 2024

AbstractIn part four of D'ailleurs, la Révélation (2020) Jean‐Luc Marion evokes the state of being seized by a saturated phenomenon, whether divinely revelatory or not, which guides one “across the desert on an anamorphic journey [parcours d'anamorphose].” The figure of anamorphosis is well‐known to anyone familiar with sixteenth‐century art, visual or literary; it comes directly from experiments with mirrors or perspective, giving rise with the latter to examples of affine transformation. Undoubtedly, Hans Holbein the Younger's double portrait “The Ambassadors” (1533) is the best‐known visual example: if one looks directly at the canvas in the National Gallery in London, one sees a diagonal blur across its bottom center, beneath Jean de Dinteville (1504‐1555), French Ambassador to London, and Georges de Selve (1508‐1541), Bishop of Lavaur and French Ambassador to the Republic of Venice. Only when one views the blur from a particular point—either low on the left‐hand side or high on the right‐hand side—can one see that it is a skull. The vanity of human achievement or, worse, human pride, is made manifest only when the artwork is viewed from a perspective that one is constrained to adopt. The sole sign of hope is a crucifix in the top left of the canvas.
Intravenous methylprednisolone therapy for ocular myasthenia gravis: A retrospective study
Authors: Yorozu Shoko , Koh Jinsoo , Miyamoto Katsuichi , Sakata Mayumi , Nakayama Yoshiaki , Takahashi Maiko , Mori Megumi , Taruya Junko , Matsumoto Takuya , Minamino Mai , Ogami Shuhei , Niwa Mayako , Hiwatani Yasuhiro , Kajimoto Yoshinori , Ishiguchi Hiroshi , Ito Hidefumi 
Published: March 2024

AbstractBackgroundAlthough intravenous methylprednisolone pulse (IVMP) therapy has been recommended for ocular myasthenia gravis (OMG), the evidence is limited.AimWe aimed to investigate the efficacy and safety of IVMP for OMG.MethodsThe patients with OMG were chosen retrospectively from May 2010 to December 2022. The therapeutic effects between IVMP‐treated and non‐IVMP‐treated groups were determined by ∆ocular quantitative MG (QMG) score and the ∆ocular MG activities of daily living profile (MG‐ADL) score, which is the disparities of the scores between before and after 1 month of drug administration; and Myasthenia Gravis Foundation of America post‐intervention status at 1, 3, 6, and 12 months.ResultsThere were 26 patients with OMG included, with the mean age of 67.2 ± 13.1 years. 13 of the 26 people with OMG received IVMP and subsequent low‐dose immunotherapies. The ∆ocular QMG and ∆ocular MG‐ADL scores were significantly higher in the IVMP group of 3 (1.5, 4) and 3 (2, 4.5) than in the non‐IVMP group of 1.5 (0, 3) and 1 (0, 2), p = 0.038 and p = 0.0027, respectively. The rates of minimal manifestation or better status in post‐intervention status at 1 and 12 months were also considerably higher in the IVMP group of 77% and 92% compared with the non‐IVMP group of 0% and 23%, p = 0.0001 and 0.001. There were no serious side effects discovered.ConclusionIVMP induction therapy can quickly and safely improve symptoms of OMG, and subsequent low‐dose immunotherapy can keep symptoms at bay for 12 months.
Lacertus notch as a sign of lacertus syndrome
Authors: Brutus Jean‐Paul , Vo Thiên‐Trang , Chang Min Cheol 
Published: March 2024

AbstractObjectiveMany clinicians are unfamiliar with a diagnosis of lacertus syndrome (LS). We investigated the value of the lacertus notch sign in diagnosing LS.MethodsWe included 56 consecutive patients (112 upper extremities) who had neuropathic pain and neurological symptoms of the hand. The presence of LS and the lacertus notch sign in each upper extremity was assessed.ResultsOf the 83 upper extremities with LS, 54 (65.1%) had a lacertus notch sign, whereas 29 (34.9%) did not. Of the 29 upper extremities without LS, 9 (31.0%) and 20 (69.0%) had and did not have a lacertus notch sign, respectively. The rates of lacertus notch presence in upper extremities with and without LS were significantly different. Of the 63 upper extremities with a lacertus notch sign, 54 (85.7%) were diagnosed with LS, whereas 9 (14.3%) were not. Of the 49 upper extremities without a lacertus notch sign, 20 (40.8%) were diagnosed with LS, and 29 (59.2%) were not. We observed significant differences in the rates of LS in upper extremities with and without lacertus notch.ConclusionsThe presence of the lacertus notch sign is useful for diagnosing LS. When patients with neuropathic pain and neurological symptoms present with a lacertus notch sign, clinicians should consider the possibility of LS.