bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ulcus ventriculi et duodeni bei Kindern.
Authors: DAHL SVEN 
Published: January 2008

ZusammenfassungUnter 62 Patienten mit Magenbeschwerden, behandlet im Vardöer Krankenhaus (Norwegen) in den Jahren 1945‐46, gab es 3 Knaben von 9–10 und 14 Jahren mit Uleus ventriculi. Dazu kam ein Fall desselben Leidens, beobachtet im Harderslev Stadt‐Krankenhaus (Dänemark). In diesem Krankenhaus fand man unter im Alter von 7–14 Jahren. Von diesen 9 Kindern waren 5 Knaben und 4 MädchenNur ein Knabe mit ulcus ventriculi hatte eine profuse Blutung (starb 23 Jahre später an Hämatemesis nachdem er in der Zwischenzeit symptomfrel gewsen war), während von den übrigen 12 Kindern nur 2 «anamnestische Meläna» hattenDa Kinder nur recht monosymptomatische Beschreibungen ihrer Leiden geben können, besteht die Möglichkeit, dass die Uleuskrankheit bei Kindern häfiger ist, als allgemien angenomenEs wird eeörtert, dass Kinder im schulpfliehtigen Alter einen Symptomenkomplex für Magengeschwür haben, der dem der Erwachsenen änlicher ist, als der Symptomkomplex, der bei kleinen Kindern zu finden ist, wo die Blutungen zu dominieren scheinen.SummaryAmong 62 patients with stomach uclers treated in the Vardö (Norway) hospital during the years 1945‐46, there were 3 boys aged 9,10 and 14, with uleus ventriculi. In addition another case with the same disease from the City Hostpital in Haderslev (Denmark) is discussed here. At the last‐named hospital there were out of 421 patients with stomach ulcers 9 children aged 9 or 10 with ulcuse dúodeni (5 boys and 4 girls). Only 1 boy with clcus ventriculi had profuse bleeding. (He died 23 years later of hematemesis, after having been free of symptoms during the intervening period). Of the other 12 children, only 2, according to anamnesis, had had melena.Inasmuch as children can describe their aliments only monosymptomatically, it is possible that they suffer from ulcers more often than is generally assumed. The possibility is discussed that the symptom complex for stomach ulcers in school‐age children resembles the symptom complex of adults more closely than that of small children, in the case of whom bleedign seems to dominate.RésuméParmis 62 patients atteints d'ulcàre de l'estomac, soignés à 1'höpital de Vardö (Norvège) en 1945‐46 on a trouvé 3 garcons de 9–10 et 14 ans ayant un ulcàre de l'estomac. A ceux‐là s'ajoute un cs de la měme maladie observéà H&#x006f;&#x030c;pital de l'Etat de Haderslev (Danemark). A ce dernier h&#x006f;&#x030c;pital on a trouvé parmi 421 patients atteints d'ulcère de l'estomac, 9 enfants de 9–10 ans ayant un ulcère du duodénum (5 garç et 4 filles). Seul un de ces enfants avait des hémorragies profuses. (II est mort 23 ans plus tard d'hématémése, aprés avoir été exempt de sympt&#x006f;&#x030c;mes durant l'époque intermédiaire). Parmi les 12 autres enfants, 2 seulement, d'après l'histoire de la maladie, ont eu le mélaena.
Heart Index or Heart Volume in Judgement of Congenital Heart Diseases
Authors: EEK SIGURD 
Published: January 2008

SummaryThe author shows by determining the size of the heart, that the heart voluine method according to S. Jonsell is superior to the heart index method. 33 cases of Fallot's tetrad and 7 of Eisen‐nienger's complex are compared. Projection of R Fallot X‐ray oon top of that of an Eisenrnenger patient shows that the heart index method does not take into consideration the depth or length of the heart and thus gives a very inexact indication of its size.RésuméL'auteur montre que dans la détermination du volume du coeur, la méthode S. Jonsell est supérieure à la méthode index. 23 cas de tétralogie de Fallot et 7 cas de coniplexe Eisenmenger sont comparés. En projetant une radiopaphie d'un patient de Fallot sur celle d'un Eisenmenger on constate que la méthode index ne tient pas compte de la profondeur ou de la longueur du coeur et ne donne donc nullenient une notion exacte de son volume.ZusammenfassungBei der Bestinimung der Grosse des Herzens fand der Autor, tiess die Herz‐Volunien‐Methode nach S. Jonsell der Herz‐Index‐Methode überlegen ist. 23 Fälle von Fsllot's Tetrade und 7 Fälle von Eisenmengers Komplex wurden verglichen. Bei der Projektion eines Röntgenbildes eines Fallot‐Patienten genau uber das eines Eisenmenger wurde gefunden, dass die Herz‐Index‐Methode die Tiefe und LBnge des Herzens nicht berücksichtigt und in keiner Weise einen genauen Ausdruck seiner Grösse gibt.ResumenPor la determinaciön del tamaiio del carazón el autor demuestra que el método de determinación del volumen del corazón ad modum S. Jonsell es superior a1 método iindice. Se comparan 23 casos de tetralogia de Fallot y 7 de complejos de Eisenmenger. Proyectando una radiografia de un paciente de Fallot sobre uno de Eisenmenger se comprueba que el método indice no toma en consideración la profundidad y la longitud del corazón y que por lo tanto no da unit expresión exacta de su tamaùo.
Paroxysmal Ventricular Tachycardia with Subsequent Myocardial Lesion
Authors: LEVANDER‐LINDGREN MAJ 
Published: January 2008

SummaryA description of a case of ventricular tachycardia with independent auricular rhythm in an 8‐year old girl with an otherwise probably sound heart. After a period with but sparse symptoms, the patient suddenly becomes cyanotic. Carotid pressure is applied and the sinus rhythm occurs. After the attack changes in all leads of the terminal complex of coronary insufficiency type were discernible. The author considers these changes to be presumptive of a myocardial lesion due to hypoxia during attacks. Changes in the amplitude of QRS, a transient increase in the height of P2 and the effect of the carotid pressure are also discussed.
Air Conditioning in Children's Hospitals
Authors: BIRCH‐LINOGREN GUSTAF , LICHTENSTEIN A. 
Published: January 2008

SummaryThe authors emphasize the necessity of considering indirect cross‐infection through the air and dust and combating cross‐infection by individual isolation in single rooms or cubicles. It is recommended to ventilate and heat these units by employing a central station air conditioning plant together with air distributing ducts. Air pressure, temperature and relative humidity must be controlled. The principles for such an installation are discussed.ZusammenfassungDie Autoren weisen auf die Notwendigkeit hin, die indirekte nosocomiale Infektion durch Luft und Staub zu beachten und zu bekämpfen durch individuelle Isolierung in Einzelräumen oder Boxen. Es wird empfohlen, diese durch Anwendung einer Centralstation als Luftversorgungsanlage mit Verteilungsrohren zu luften und zu heizen.RésuméL'auteur insiste sur la néessité de prendre en considération les infections nosocomiales indirectes causées par l'air et la poussière et de combattre ces infections par l'isolation individuelle en chambre ou cabinet privés. II est recommandé d'aérer et de chauffer ces pièces au moyen d'un appareil central de chauffage et de ventilation avec des tuyaux distributeurs d'air. La pression atmosphérique, la température et l'humidité relative doivent être controlées. Les principes d'une telle installation sont discutés.ResumenLos autores recalcan la necesidad de tomar en consideración la infección cruzada indirecta por aire y polvo, y de combatirla por medio de aislamiento individual en piezas aisladas. Se recomienda ventilar y calentar estos cuartos usando una estación central con una instalación de aire acondicionado en combinación con conductos distribuidores de aire. Es necesario controlar la presión del aire, la temperatura y la humedad relativa. Se discuten los principios de una instalación de esta clase.
Essential Fructosuria
Authors: BROMAN BIRGER 
Published: January 2008

SummaryA study is made of the sugar metabolism in an 8‐gear‐old girl suffering from fructosuria.Neither the administration of adrenalin nor of insulin affected the excretion of sugar in the urine. The only way in which the fructosuria could be decreased despite the administration of sugars was by fructose deprivation, i. e. the exclusion of fruit from the diet and the replacement, as far us possible, of ordinary sugar with the same quantity of pure glucose.Six years after the first examination the patient shows normal development but the fructosuria is still present.RésuméUne étude du métabolisme du sucre chez une fillette de 8 ans souffrant de fructosurie.Ni l'adrénaline, ni l'insuline n'ont empêché l'excrétion du sucre dans l'urine. La seule manièe dont la fructosurie puisse être diminuée, malgré l'administration de sucre, était la privation de fructose c‐à‐d l'exclusion des fruits dans l'alimentation et le remplacenient, autant que possible, du sucre ordinaire par la nême quantité de glucose pur.Six ans après le premier examen la patiente montrait un développement normal mais la fructosurie était encore présente.ZusammenfassungEs wurde eine Untersuchung gemacht über den Zuckerumsatz bei einem jährigen Mädchen, das an Fruktosurie litt.Weder die Anwendung von Adrenalin noch Insulin beeinflusste die Zuckerausscheidung im Urin. Der einzige Weg, auf dem die Fruktosurie vermindert werden konnte, trotz Verabreiehung yon Zucker, war die Entziehung von Fruktose, d. h. das Ausschalten von Obst aus der Diät und der Ersatz, so weit das möglich war, des gewöhnlichen Zuckers durch dieselbe Menge reiner Glykose.6 Jahre nach der ersten Untersuchung zeigte die Patientin normale Entwicklung, aber die Fruktosurie ist dauernd vorhanden.ResumenSe estudia el metabolisnio de azúcar en una muchacha de 8 años que sufre de fructosuria.Ni la administraión de adrenalina ni la de insulina afectaban la excreción de azúcar en la orina. La única manera por la cual se podía disminuir la fructosuria, no obstante la administración de azúcar, fué por medio de la privación fructosa, es decir, la exclusion de fruta en la dieta y su reemplazamiento, en la medida de lo posible, por azúcar corriente con la misma cantidad de glucosa pura.Seis años después del primer examen el eiifermo mostró normal desarrollo, pero la fructosuria persiste todavía.
Pulmonary Insufficiency
Authors: MOSSBERG HANS‐OLOF 
Published: January 2008

SummaryA case of pulmonary insufficiency in a girl of 11 with pulmonary fibrosis and pronounced clubbing of the digits is described. The pulmonary function was investigated according to the schedule of Cournand & Richards. Autopsy findings confirmed the diagnosis of interstitial pulmonary fibrosis. The case illustrates the symptomatic similarity between cardiac and pulmonary insufficiency with dyspnoe and cyanosis and also the present day means of analysis and specific diagnosis.RésuméUn cas d'insuffisance pulmonaire chez une fillette de 11 ans ayant une fibrose pulmonaire et des doigts hippocratiques prononcés. La fonction pulmonaire a été examinée d'aprés le schéma de Cournand & Richards. L'autopsie confirme le diagnostic de fibrose pulmonaire interstitiel. Le cas met en lumière la similitude symptômatique entre l'insuffisance cardiaque et l'insuffisance pulmonaire avec dyspnée et cyanose ainsi que les possibilités d'analyse et de diagnostic spécial que l'on a aujourd'hui.ZusammenfassungEs wird ein Fall von Pulmonaler Insuffizienz bei cincm 11‐jährigen Mädchen mit Lungenfibrose und ausgeprägten Trommelschlägelfingern berichtet. Die Lungenfunktion wurde nach dem Cournand & I˜ichards Schema untersucht. Die Sektion bestätigte die Diagnose: interstitielle Lungenfibrose. Der Fall illustriert die Symptomgleichheit zwischen cardialer und pulmonaler Insuffizienz mit Dyspnoe und Cyanose, sowie die Möglichkeiten zur Analyse und Spezialdiagnose, die es jetzt gibt.ResumenSe describe un caso de insuficiencia pulmonar en una muchacha de 11 años que tenía fibrosis pulmonar y pronunciado trabamiento de los dedos. Se esaminó el funcionamiento pulmonar de acuerdo con el plan de Cournand & Richards. Hallazgos por medio de autopsia confirmaron la diagnosis de fibrosis pul monar intersticial. El caso demuestra la semejanza sintomática entre insuficiencia cardiaca, insuficiencia pulmonar con disnea y cianosis, y también entre los medios de hoy día de análisis y diagnosis específica.
Cystine Storage Disease with Aminoaciduria and Dwarfism (LIGNAC—FANCONI DISEASE): INTRODUCTION
Authors: BICKEL H. , SMALLWOOD W. C. , SMELLIE J. M. , BAAR H. S. , HICKMANS E. M. 
Published: January 2008

SummaryFourteen children suffering from cystine storage disease with aminoaciduria (Lignac‐Fanconi disease) have been studied i n the last 3 years, and the results are described in a series of eight papers of which this first paper contains a short review of the literature, some general remarks on aminoaciduria, cystinuria and cystine storage, and a brief statement on some of the results obtained and conclusions reached.Publications by Lignac, Fanconi, Beuiner and Wepler, and others, as well as our own observations, lead us t o the conclusion that Lignac's disease (cystine storage disease) and Fanconi's syndrome of childhood (nephrotic glycosuric dwarfism) are one and the same disease. At the present time this disease cannot be identified with similar syndromes in which cystine storage has been excluded.The variability of nearly every symptom in Lignac‐Fanconi disease is stressed. The most reliable diagnostic features besides dwarfing are cys tine storage and aminoaciduria of a characteristic pattern. Cystine storage can be demonstrated in vivo by slit‐lamp investigation in cornea and conjunctiva, as well as in bone marrow and lymph glands, and the cystine can be identified in biopsy material by microscopy, X‐ray crystallography and chromatography.The aminoaciduria is accompanied by aminoacidaemia, and the characteristic pattern in urine is best shown by paper chromatography. The differentiation from other forms of aminoaciduria, such as that of newborn infants and classical cystinuria, is discussed.Reasons are given why cystine storage and aminoaciduria are regarded as the result not of kidney dysfunction but of a prerenal disturbance of the whole aminoacid metabolism, probably situated within the reticulo‐endothelial system.
THE GENETICS OF LIGNAC‐FANCONI DISEASE
Authors: BICKEL H. , HARRIS H. 
Published: January 2008

SummaryLignac‐Fanconi disease has often been described in siblings but never in different generations. Our findings in the families of eight patients, including chromatographic studies of 138 urine specimens, confirm these observations. Of a total of 19 siblings four were probably and one certainly affected. No other relatives suffered from the disease. Consanguinity was found in one family; its incidence also seems to be raised in the literature. The data suggest that Lignac‐Fanconi disease is genetically determined and of simple Mendelian recessive character, but that it is not genetically related to classical cystinuria or to the so‐called Fanconi syndrome in adults. The frequency of Lignac‐Fanconi disease in the general population is estimated to be roughly 1 in 40,000 with a gene frequency of 1 in 200. The genetical prognosis is believed to be 1 in 4 for any subsequent child of parents who already have one sick child. Corresponding figures are given for cousins of the patient and for children of the patient's sibs.
THE OPHTHALMOLOGY OF LIGNAC‐FANCONI DISEASE
Authors: DOUGLAS A. A. , BICKEL H. 
Published: January 2008

SummaryThe ophthalmological appearances in five cases of Lignac‐Fanconi disease have been studied. Jn every case crystalline deposits were seen in cornea and conjunctiva, in two cases in the iris, but never in the lens, vitreous or other media of the eye. Massive deposition was easily recognisable by loupe and may even be suspected by naked eye examination. In less developed cases the crystalline deposits were visible only by use of a slit‐lamp; the application of this technique in uncooperative children is described.Microscopy of a conjunctiva biopsy specimen revealed that the crystals were partly hexagonal, their localisation being intra‐ and extra‐cellular. The ninhydrin test gave a diffusely positive reaction. X‐ray diffraction photography of the biopsy specimen showed the pattern to be entirely characteristic of pure crystalline cysline.In two patients with severe photophobia epithelial lesions of the cornea were shown by staining with fluorescin. This change was absent in the patients without photophobia and is in our opinion the immediate cause of the photophobia.The eye appearances in Lignac‐Fanconi disease are sufficiently characteristic to eliminate any serious diagnostic difficulty.
MORBID ANATOMY, HISTOLOGY AND PATHOGENESIS OF LIGNAC‐FANCONI DISEASE: (Cystine Storage Disease with Aminoaciduria)
Authors: BAAR H. S. , BICKEL H. 
Published: January 2008

SummaryDetailed gross anatomical and histopathological findings in six cases of Lignac‐Fanconi disease are described and discussed. An attempt is made to present the natural history of individual organ changes, particularly those of the kidney. It is interesting to note that the disease in its early stages can occur without kidney changes. The bone changes are essentially rachitic; there is no feature of the histopathology of the bones which is not met with in rickets, particularly in “rachitis tarda.” Bone changes suggestive of hyperpara‐thyroidism are not conspicuous in this disease. The parathyroids were markedly hypertrophic in two of our cases; hypertrophy in other cases cannot be excluded.The phosphatase reaction was negative in all kidneys examined, reduced in liver, spleen and bone‐marrow but normal in the small intestine. Negative phosphatase reaction in the kidney has also been found in chronic inflammatory kidney disease and is not specific for Lignac‐Fanconi disease.Methods for demonstration and identification of cystine crystals in tissue sections, bone‐marrow films and lymph node imprints are described, together with experiments which account for the difference between the crystallographic appearance of cystine in tissues and cystine crystallised from aqueous solutions. In our opinion a lymph node biopsy is the most reliable procedure for a definite diagnosis of Lignac‐Fanconi disease in vivo, though bone‐marrow sections and/or films are usually sufficient for the purpose.The intracellular localisation of cystine crystals is stressed, and histopathological and experimental evidence is given for the assumption that cystine storage is not due to phagocytosis, but that cystine crystallises at the site of its formation, namely in a certain part of the reticuloendothelial system.A critical review is given of various hypotheses concerning the pathogenesis of Lignac‐Fanconi disease. The hypothesis is put forward that Lignac‐Fanconi disease is a disorder of protein metabolism, probably of its anabolic phase. As a disorder of intracellular metabolism, the disease is likened to true lipidoses.
Alkyl Mercury Poisoning
Authors: ENGLESON GUNNAR , HERNER TORSTEN 
Published: January 2008

SummaryThis paper describes a case of organic mercury poisoning in a child from a mercury‐intoxicated family. The condition has not hitherto been reported among children. The child was poisoned after eating porridge prepared from flour which had been treated with an dkyl mercury compound, panogen, which is used by farmers in seed dressing. The main clinical signs and symptoms are due to severe damage to brain tissue, and thus differ from the parenchymatous lesions resulting from inorganic mercury poisoning. Treatment with BAL was of doubtful value.
Another Case of Niemann‐Pick's Disease Observed in Denmark
Authors: VIDEBÆK AAGE 
Published: January 2008

SummaryA caae of Niemann‐Pick's disease is reported in a boy of 5 months. He exhibited increased values of phospholipoids, cholesterol, and neutral fat in the serum. The same condition was previously reported in his elder brother, but does not appear to have occurred among more distant relatives. The parents are first cousins.
Psychogenic Anorexia and Hyperorexia among Siblings
Authors: TOLSTRUP KAI 
Published: January 2008

SummaryAn examination of two sisters with psychogenic hyperorexia and anorexia respectively; and two brothers of another family with the same symptoms, make up the background of a discussion of the relations between anorexia and hyperorexia.In Family I anorexia in the younger girl seems to be the primary disturbanoe of appetite in the surroundings. The sister's hyperorexia should be regarded as a direct outcome of the younger sister's eating‐inhibition, an attempt to keep up the position at home that she felt threatened when the little one wm born. The adequacy of this mechanism appears from the predominant part that food plays in the house.In Family II there is no such connection between the symptoms of the two brothers. The younger suffers from anorexia, in this case a regressive mechanism, probably with a dyspepsia in babyhood as starting‐point. His brother has during his early years displayed various psychogenic symptoms — fits suggesting asthma, enuresis nocturna, several behaviour‐disturbances — and finally hyperorexia, which apparently is a link in the chain of symptoms. The family is dominated by a perfectionist mother. The reason why both children should react against these surroundings with disturbances of appetite does not appear from the examination.Two different kinds of psychical expression are found in these four children, partly a passive, non‐protesting type, partly an active, aggressive type. In one family the passive expression is combined with hyperorexia and the active one with anorexia; in the other family it is the other way round.The advantage of connecting anorexia with hyperorexia is emphasized. The introduction of the common term psychogenic dysorexia is suggestad for the symptoms concerned, in order to call attention to the common source: disturbed appetite.
The Programme for Premature Infants in Gothenburg, Sweden. The Principles of Treatment and the Results Obtained
Authors: HOLMDAHL KURT 
Published: January 2008

SummarySince the commencement of the year 1948, distinctly improved results have been achieved in the care of the premature infants in Gothenburg. An account is given of some new principles of ‘treatment. The value of oxygen administration, particularly gastrointestinal administration, and the theoretical (Table 1) and practical advantages of human colostrum as a nourishing medium for the premature infants are stressed.In order to judge the results of care, the mortality in three other series of premature infants is compared with the author's own series (Table 2). An analysis of the mortality in the different weight groups shows that a very favourable figure was reached in the Gothenburg series in the weight group 1510–2000 g. For the weight groups 1010–1500 and 2010–2500 g, the mortality was lowest in the series from Denver.From the distribution of the deaths with a considerable peak immediately after birth (Fig. 1) and from the nature of the causes of death it appears that disturbances of nutrition and infections were seldom the cause of death.A more substantial reduction of the mortality for premature infants in Gothenburg is only possible by reducing the mortality in the first 48 hours. An intensified cooperation between pediatricians and obstetricians is necessary.
Congenital Toxoplasmosisl
Authors: GARD SVEN , MAGNUSSON J. HENNING , HAGBERG ERIK 
Published: January 2008

SummaryAfter a description of the classical syndrome in congenital toxoplasmosis five cases encountered by the writers are presented. In one of these patients, who was observed during the active stage of the process, toxoplasma were demonstrated in the ventricular fluid. This case displayed all the typical signs and symptoms of the disease. The other cases displayed varying degrees of severity, and the diagnosis in these patients is based on the results of the serologic examinations. I an unequivocal case of toxoplasma infection (asymptomatic) in the mother, a large diaphragmatic hernia was observed in the premature infant. Unfortunately, this case was not investigated satisfactorily, and it is not possible to make any statement regarding the cause of the abnormality.A follow‐up investigation on six mothers of infants with diaphragmatic hernia failed to yield evidence in support of the theory that toxoplasmosis might be a cause of such malformations.