bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biocompatibility and bioactive potential of NeoPUTTY calcium silicate‐based cement: An in vivo study in rats
Authors: Silva Evelin Carine Alves , Pradelli Jéssica Arielli , da Silva Guilherme Ferreira , Cerri Paulo Sérgio , Tanomaru‐Filho Mario , Guerreiro‐Tanomaru Juliane Maria 
Published: March 2024

AbstractAimTo evaluate the inflammatory reaction and the ability to induce mineralization activity of a new repair material, NeoPUTTY (NPutty; NuSmile, USA), in comparison with Bio‐C Repair (BC; Angelus, Brazil) and MTA Repair HP (MTA HP; Angelus, Brazil).MethodologyPolyethylene tubes were filled with materials or kept empty (control group, CG) and implanted in subcutaneous tissue of rats for 7, 15, 30, and 60 days (n = 6/group). Capsule thickness, number of inflammatory cells (ICs), fibroblasts, collagen content, and von Kossa analysis were performed. Unstained sections were evaluated under polarized light and by immunohistochemistry for osteocalcin (OCN). Data were submitted to two‐way anova followed by Tukey's test (p ≤ .05), except for OCN. OCN data were submitted to Kruskal–Wallis and Dunn and Friedman post hoc tests followed by the Nemenyi test at a significance level of 5%.ResultsAt 7, 15, and 30 days, thick capsules containing numerous ICs were seen around the materials. At 60 days, a moderate inflammatory reaction was observed for NPutty, BC while MTA HP presented thin capsules with moderate inflammatory cells. In all periods, NPutty specimens contained the highest values of ICs (p < .05). From 7 to 60 days, the number of ICs reduced significantly while an increase in the number of fibroblasts and birefringent collagen content was observed. At 7 and 15 days, no significant difference was observed in the immunoexpression of OCN (p > .05). At 30 and 60 days, NPutty showed the lowest values of OCN (p < .05). At 60 days, a similar immunoexpression was observed for BC and MTA HP (p > .05). In all time intervals, capsules around NPutty, BC, and MTA HP showed von Kossa‐positive and birefringent structures.ConclusionsDespite the greater inflammatory reaction promoted by NeoPutty than BC and MTA HP, the reduction in the thickness of capsules, the increase in the number of fibroblasts, and the reduction in the number of ICs indicate that this bioceramic material is biocompatible Furthermore, NeoPutty presents the ability to induce mineralization activity.
Real‐Life Comparison of Antivirals for SARS‐CoV‐2 Omicron Infection in Patients With Hematologic Malignancies
Authors: Aiello Tommaso Francesco , Peyrony Olivier , Chumbita Mariana , Monzó Patricia , Lopera Carlos , Puerta‐Alcalde Pedro , Magnano Laura , Fernández‐Avilés Francesc , Cuesta Genoveva , Tuset Montse , Mensa Josep , Esteve Jordi , Marcos Maria Angeles , Soriano Alex , Garcia‐Vidal Carolina 
Published: March 2024

ABSTRACTBackgroundWe aimed to describe a cohort of hematologic patients with COVID‐19 treated with antivirals early.MethodsNon‐interventional chart review study. Comparison of baseline characteristics and outcomes in high‐risk hematologic patients treated with remdesivir between December 2021 and April 2022 versus those treated with nirmatrelvir/ritonavir between May and August 2022.ResultsEighty‐three patients were analyzed. Forty‐two received remdesivir, and 41 nirmatrelvir/ritonavir. Patients with remdesivir were younger, vaccinated with lower number of doses, and received prior corticosteroids less frequently and sotrovimab, hyperimmune plasma and corticosteroids more often. Viral shedding median (IQR) duration was 18 (13–23) and 11 (8–21) days in the remdesivir and nirmatrelvir/ritonavir groups, respectively (p = 0.004). Median (IQR) Ct values before treatment were similar in both groups. Within 5 days of treatment, median (IQR) Ct values were 26 (23–29) and 33 (30–37) in the remdesivir and nirmatrelvir/ritonavir groups, respectively (p < 0.0001). All patients were hospitalized for remdesivir administration and only four (9.8%) in the nirmatrelvir/ritonavir group. The overall outcomes in this cohort of COVID‐19 patients with Omicron variant was good, as no patient needed oxygen or ICU admission. One patient in remdesivir group died from septic shock. No severe adverse event was recorded in both treatment groups.ConclusionsPatients with hematologic malignancies and non‐severe COVID‐19 who received nirmatrelvir/ritonavir experienced faster decrease in viral load and shorter viral shedding. Furthermore, besides the advantage of oral administration, nirmatrelvir/ritonavir administration reduced the need of hospital admission.
Improvement of palliative care for people with intellectual disabilities: A multi‐site evaluation
Authors: De Veer Anke J. E. , Voss Hille , Francke Anneke L. , de Man Y. 
Published: March 2024

AbstractBackgroundTo improve the quality of palliative care, six evidence‐based tools were implemented in 10 care services specialised in care for people with intellectual disabilities. Contextual differences were taken into account by using a participatory action research approach.MethodThe RE‐AIM framework (Reach, Effectiveness, Adoption, Implementation and Maintenance) structured the evaluation. Data sources were online questionnaires completed by 299 professionals at baseline (response 45.2%) and 250 professionals after 2.5 years (35.1%), 11 semi‐structured group interviews with 43 professionals, field notes and implementation plans.ResultsA total of 767 professionals and 43 teams were reached. The effectiveness of the intervention was demonstrated in an improved knowledge of palliative care policy and increased competences among professionals. 79% of the professionals adopted tools in the toolbox. The participatory action research method was perceived as valuable in driving change.ConclusionsImproving palliative care needs a context‐specific, flexible approach, with involvement of all stakeholders.
Association of tooth location, occlusal support and chewing ability with cognitive decline and incident dementia
Authors: Asher Sam , Suominen Anna Liisa , Stephen Ruth , Ngandu Tiia , Koskinen Seppo , Solomon Alina 
Published: March 2024

AbstractAimEmerging evidence suggests association of tooth loss with impaired cognition. However, the differential effects of anterior versus posterior tooth loss, occlusal support loss and chewing ability are not considered comprehensively.Materials and MethodsWe conducted cross‐sectional (N = 4036) and longitudinal analyses (N = 2787) on data from Health 2000 and 2011 Surveys for associations of posterior occlusal support loss, anterior versus posterior tooth loss, and chewing ability with baseline cognition and 11‐year cognitive decline. Additionally, 15‐year incident dementia risk was investigated (N = 4073).ResultsAfter considering relevant confounders and potential reverse causality bias, posterior occlusal support loss significantly increased dementia risk across all categories indicative of posterior occlusal support loss (hazard ratios [HRs] between 1.99 and 2.89). Bilateral inadequate posterior occlusal support was associated with 11‐year decline in overall cognition (odds ratio [OR] = 1.48:1.00–2.19), and unilateral inadequate posterior occlusal support with total immediate (OR = 1.62:1.14–2.30) and delayed recall decline (OR = 1.45:1.03–2.05). Moreover, posterior tooth loss was associated with dementia (HR = 2.23:1.27–3.91) and chewing ability with total immediate decline (OR = 1.80:1.04–3.13).ConclusionsPosterior tooth and occlusal support loss significantly increases dementia risk. The impact of posterior occlusal support loss appears to be dose‐dependent, and this effect is distinct from that of dentures. Dental healthcare services should be particularly attentive to the state of posterior dentition. Further studies exploring possible mechanisms are warranted.
The metamorphic footprint of western Laurentia preserved in subducted rocks from southern Australia
Authors: Brown Dillon A. , Morrissey Laura J. , Hand Martin , Mulder Jacob A. , Wade Benjamin , Barrote Vitor 
Published: March 2024

AbstractPolymetamorphic metapelitic rocks in central‐west Tasmania, southern Australia, contain high‐pressure mineral assemblages that formed during Cambrian‐aged subduction and relict garnet with published Lu–Hf ages of c. 1285–1240 Ma. These garnet ages, along with published detrital zircon data from throughout western Tasmania and western North America, have been used to propose the presence of Mesoproterozoic Laurentian crust in western Tasmania. In this study, we combine zircon petrochronology with compositional information from the inclusion assemblages in relict garnet to extract Mesoproterozoic pressure–temperature data from subduction‐overprinted rocks, which effectively constitute an interpreted remnant of Laurentian crust now residing in central‐west Tasmania. The new data suggest Mesoproterozoic metamorphism involved two stages. The first event is recorded by c. 1480–1235 Ma zircon that formed in a garnet‐absent, plagioclase‐present, high‐thermal gradient environment at pressures no greater than ~5–5.5 kbar. The second event recorded by c. 1285–1240 Ma relict garnet was characterized by the development of a moderate‐pressure kyanite–plagioclase–biotite‐bearing mineral assemblage, which formed at ~8.5 kbar and ~590–680°C. These pressure–temperature constraints are attributed to extension within a deep basin system associated with the cryptic East Kootenay Orogeny in North America, which coincides with the final stages of c. 1450–1370 Ma upper Belt‐Purcell Basin sedimentation. Taking into account new detrital zircon U–Pb–Hf isotopic data from central‐west Tasmania in this study and existing zircon provenance data from throughout western Tasmania and the Belt‐Purcell Basin, our results strengthen the hypothesis of a Laurentian footprint that potentially encompasses much of western Tasmania and relates to both Nuna and Rodinian tectonism.
Short‐term personality development and early career success: Two longitudinal studies during the post‐graduation transition
Authors: Hotze Mary‐Louise , Liu Zihan , Chu Chu , Baranski Erica , Hoff Kevin A. 
Published: March 2024

AbstractObjectiveInvestigate short‐term personality development during the post‐graduation transition.BackgroundPrior research indicates that long‐term personality development matters for employment outcomes. However, this evidence is primarily limited to multi‐year longitudinal studies. This research switches the focus to personality changes during a shorter, impactful life transition.MethodWe examined how short‐term personality development during the 14‐month post‐graduation transition relates to early career outcomes among two diverse samples of graduates from universities (N = 816) and community colleges (N = 567). We used latent growth curve models to examine associations between career outcomes measured 14 months after graduation with initial personality levels and personality changes.ResultsResults revealed that mean‐level changes in personality were small and mostly negative. Moreover, individual differences in personality changes were not associated with career outcomes. However, initial levels of conscientiousness, emotional stability, and extraversion positively related to both subjective and objective career success. Initial levels of agreeableness were also positively related to subjective (but not objective) success.ConclusionsFindings indicate that individual differences in personality trait levels at graduation are stronger predictors of early career success compared to short‐term personality changes during the post‐graduation transition. Taken together, these results help define the time sequence through which personality changes relate to career outcomes.
Investigating the effects of tauroursodeoxycholic acid (TUDCA) in mitigating endoplasmic reticulum stress and cellular responses in Pak choi
Authors: Ayaz Aliya , Jalal Abdul , Qian Zhou , Khan Khalid Ali , Liu Liwang , Hu Chunmei , Li Ying , Hou Xilin 
Published: March 2024

AbstractThe accumulation of misfolded proteins in the endoplasmic reticulum (ER) within plant cells due to unfavourable conditions leads to ER stress. This activates interconnected pathways involving reactive oxygen species (ROS) and unfolded protein response (UPR), which play vital roles in regulating ER stress. The aim of this study is to investigate the underlying mechanisms of tunicamycin (TM) induced ER stress and explore the potential therapeutic applications of tauroursodeoxycholic acid (TUDCA) in mitigating cellular responses to ER stress in Pak choi (Brassica campestris subsp. chinensis). The study revealed that ER stress in Pak choi leads to detrimental effects on plant morphology, ROS levels, cellular membrane integrity, and the antioxidant defence system. However, treatment with TUDCA in TM‐induced ER stressed Pak choi improved morphological indices, pigment contents, ROS accumulation, cellular membrane integrity, and antioxidant defence system restoration. Additionally, TUDCA also modulates the transcription levels of ER stress sensors genes, ER chaperone genes, and ER‐associated degradation (ERAD) genes during ER stress in Pak choi. Furthermore, TUDCA has demonstrated its ability to alleviate ER stress, stabilize the UPR, reduce oxidative stress, prevent apoptosis, and positively influence plant growth and development. These results collectively comprehend TUDCA as a promising agent for mitigating ER stress‐induced damage in Pak choi plants and provide valuable insights for further research and potential applications in crop protection and stress management.
Are the P600 and P3 ERP components linked to the task‐evoked pupillary response as a correlate of norepinephrine activity?
Authors: Contier Friederike , Wartenburger Isabell , Weymar Mathias , Rabovsky Milena 
Published: March 2024

AbstractDuring language comprehension, anomalies and ambiguities in the input typically elicit the P600 event‐related potential component. Although traditionally interpreted as a specific signal of combinatorial operations in sentence processing, the component has alternatively been proposed to be a variant of the oddball‐sensitive, domain‐general P3 component. In particular, both components might reflect phasic norepinephrine release from the locus coeruleus (LC/NE) to motivationally significant stimuli. In this preregistered study, we tested this hypothesis by relating both components to the task‐evoked pupillary response, a putative biomarker of LC/NE activity. 36 participants completed a sentence comprehension task (containing 25% morphosyntactic violations) and a non‐linguistic oddball task (containing 20% oddballs), while the EEG and pupil size were co‐registered. Our results showed that the task‐evoked pupillary response and the ERP amplitudes of both components were similarly affected by both experimental tasks. In the oddball task, there was also a temporally specific relationship between the P3 and the pupillary response beyond the shared oddball effect, thereby further linking the P3 to NE. Because this link was less reliable in the linguistic context, we did not find conclusive evidence for or against a relationship between the P600 and the pupillary response. Still, our findings further stimulate the debate on whether language‐related ERPs are indeed specific to linguistic processes or shared across cognitive domains. However, further research is required to verify a potential link between the two ERP positivities and the LC/NE system as the common neural generator.
Convergent and divergent parental emotion socialization processes shape children's emotional responding
Authors: DeLoretta Laura , Davis Elizabeth L. 
Published: March 2024

AbstractParents have an essential role in shaping children's emotional responses, a process called emotional socialization. Typically, researchers measure parental socialization behaviors via self‐report and in‐laboratory observations. However, the extent to which there is convergence between parents’ reported and enacted socialization practices is an open question. The aims of the current study were (1) to quantify the convergence/divergence in parents’ reported and enacted emotional socialization practices and (2) to analyze how convergence/divergence in specific parent socialization practices relates to children's emotional responding across different contexts (alone and with a parent). Participants were a diverse sample of 181 parent‐child dyads (children ages 3–11). We analyzed emotion socialization strategies (problem‐focused reactions, emotion‐focused reactions, expressive encouragement, punishing reactions, minimizing reactions, and distress reactions) as they related to children's behavioral and physiological responding to an emotional challenge. We found an overall pattern of divergence for most socialization strategies, but convergence for problem‐focused reactions. For children's observed distress, a convergent pattern of reported and enacted minimizing specifically was related to more distress while alone. For children's physiological reactivity, enacted problem‐solving was related to greater parasympathetic decreases across social context (from being alone to being with parent). Taken together, our findings suggest that convergence and divergence in parental emotional socialization practices may capture unique variability in how parents contextually respond to children's feelings, and children's emotional responding.
ɸ‐Agree with silent goals and the theory of interface effects*
Authors: Jarrah Marwan , Al‐Deaibes Mutasim , Hammouri Yazeed 
Published: March 2024

AbstractThis article provides evidence from Arabic (namely Modern Standard Arabic and Jordanian Arabic) that ɸ‐Agree with an element which undergoes a phonological deletion at PF, i.e., a pro, results in the occurrence of a ɸ‐inflection of the goal on the relevant probe. This occurrence is imposed by the effects of a suggested interface condition, named as The Agree Identification Condition, which requires a phonologically null goal to be ɸ‐identified through a co‐varying ɸ‐inflection on its probe. Such an analysis directly accounts for the intriguing observation that ɸ‐inflections in Arabic do not occur on heads (e.g., verbs and prepositions) when the latter ɸ‐agree with an overt DP. Additionally, this article shows that the effects of this condition do not arise when the Agree relation occurs between a probe and an unpronounced goal which is a member of a movement chain. When one link of the chain (e.g., the higher copy) is overt, no ɸ‐inflection of the goal would appear on the probe. This suggests that when a probe ɸ‐agrees with a goal which constitutes one link of a movement chain, the Agree relation holds between the probe and the whole chain.
SlWRKY81 regulates Spd synthesis and Na+/K+ homeostasis through interaction with SlJAZ1 mediated JA pathway to improve tomato saline‐alkali resistance
Authors: Shang Chunyu , Liu Xiaoyan , Chen Guo , Li Guobin , Hu Songshen , Zheng Hao , Ge Lei , Long Yanghao , Wang Qiaomei , Hu Xiaohui 
Published: March 2024

SUMMARYSaline‐alkali stress is an important abiotic stress factor affecting tomato (Solanum lycopersicum L.) plant growth. Although the involvement of the tomato SlWRKY gene family in responses to saline‐alkali stress has been well established, the mechanism underlying resistance to saline‐alkali stress remains unclear. In this study, we investigated the role of SlWRKY81 in conferring saline‐alkali stress resistance by using overexpression and knockout tomato seedlings obtained via genetic modification. We demonstrated that SlWRKY81 improves the ability of tomato to withstand saline‐alkali stress by enhancing antioxidant capacity, root activity, and proline content while reducing malondialdehyde levels. Saline‐alkali stress induces an increase in jasmonic acid (JA) content in tomato seedlings, and the SlWRKY81 promoter responds to JA signaling, leading to an increase in SlWRKY81 expression. Furthermore, the interaction between SlJAZ1 and SlWRKY81 represses the expression of SlWRKY81. SlWRKY81 binds to W‐box motifs in the promoter regions of SlSPDS2 and SlNHX4, thereby positively regulating their expression. This regulation results in increased spermidine (Spd) content and enhanced potassium (K+) absorption and sodium (Na+) efflux, which contribute to the resistance of tomato to saline‐alkali stress. However, JA and SlJAZ1 exhibit antagonistic effects. Elevated JA content reduces the inhibitory effect of SlJAZ1 on SlWRKY81, leading to the release of additional SlWRKY81 protein and further augmenting the resistance of tomato to saline‐alkali stress. In summary, the modulation of Spd synthesis and Na+/K+ homeostasis mediated by the interaction between SlWRKY81 and SlJAZ1 represents a novel pathway underlying tomato response to saline‐alkali stress.
Minimal surfaces with symmetries
Authors: Forstnerič Franc 
Published: March 2024

AbstractLet be a finite group acting on a connected open Riemann surface by holomorphic automorphisms and acting on a Euclidean space by orthogonal transformations. We identify a necessary and sufficient condition for the existence of a ‐equivariant conformal minimal immersion . We show in particular that such a map always exists if acts without fixed points on . Furthermore, every finite group arises in this way for some open Riemann surface and . We obtain an analogous result for minimal surfaces having complete ends with finite total Gaussian curvature, and for discrete groups acting on properly discontinuously and acting on by rigid transformations.
Comprehensive Flow Path Design Method for the Adaptive Cycle Engine Considering the Coupling Relation of Multiple Components
Authors: Xu Zhewen , Liu Xin , Chen Min , Tang Hailong , Zhang Jiyuan 
Published: March 2024

Abstract
The adaptive cycle engine (ACE) has multiple coupled components on the same spool and complex bypass system, which makes it have more complex intercomponent coupling relation and hard to coordinate in the flow path design. In this study, the coupling relation of the ACE components and the component reference conditions are analyzed and determined, a multicomponent collaborative optimization design method is proposed to enable the quantitative evaluation of flow path design solutions. In this method, two optimization strategies are presented based on the different priorities of the intercomponent size coupling parameters, the intercomponent aerodynamic coupling parameter and the component performance in the optimization problem. ACE flow path solutions for various feasible design speed combinations are generated automatically considering the component performance and intercomponent coupling relation. According to an ACE flow path design case study, the design physical rotational speeds of low-pressure spool (NL,d) and high-pressure spool (NH,d) should be 7000 to 7600 r/min and 10,000 to 15,000 r/min, respectively. At NH,d = 12,000 r/min and NL,d = 7200 r/min, the high-pressure compression components and the fan components could be designed with the lowest aerodynamic load, respectively. NH,d is the key factor affecting the axial length of ACE. This method can be applied to other gas power plant designs.