bluuebunny/crossref_metadata_2025_split huggingface dataset:
Empagliflozin-loaded nanomicelles responsive to reactive oxygen species for renal ischemia/reperfusion injury protection
Authors: Cheng Jianjun , Zhang Xin , Zheng Qiang , Shi Shaohua , Wang Jianping 
Published: April 2024

Abstract
The brain, heart, liver, kidney, and other organs are susceptible to the harmful effects of ischemia-reperfusion injury (IRI), where the excessive production of reactive oxygen species (ROS) following IRI contributes to tissue damage and ensuing inflammation. In recent years, researchers have designed various nanoparticles that are responsive to ROS for the treatment of IRI. Empagliflozin (EMPA), an inhibitor of the sodium-glucose cotransporter-2 commonly used in type 2 diabetes mellitus, shows promise in mitigating IRI. However, its water-insolubility and low bioavailability present challenges in fully realizing its therapeutic efficacy. To tackle this issue, we formulated EMPA-loaded nanomicelles designed to respond to ROS, aiming to prevent renal damage caused by ischemia-reperfusion. Extensive characterization confirmed the effectiveness of the formulated nanomicelles. Through simulations and release studies, we observed structural modifications in the micelles leading to the release of EMPA upon encountering ROS (H2O2). In animal studies, rats treated with EMPA-loaded micelles showed normal renal tissue architecture, with only some remaining tubular swelling. Molecular assessments revealed that IRI triggered cell apoptosis through mechanisms involving hypoxia, metabolic stress, ROS, and TNF-α elevation. EMPA treatment reversed this process by upregulating B-cell lymphoma protein 2 and reducing levels of associated X (BAX) protein, Caspase 3, and Caspase 8. These results indicate that ROS-responsive micelles could act as a spatially targeted delivery system, effectively transporting EMPA directly to the ischemic kidney. This offers a promising therapeutic strategy for alleviating the impact of renal IRI.
Holocaust***Gulag: Repressing, Rescuing, and Regulating Recalcitrant Legacies
Authors: Krondorfer Björn , Tolstaya Katya 
Published: April 2024

Abstract
Is it possible to bring into conversation two different traumatic legacies that occurred in the twentieth century in Europe? How can we engage in productive conversation about two totalitarian systems that repressed, incarcerated, dehumanized, and murdered people deemed enemies of the state or unworthy of living? These were some of the challenging questions addressed in the roundtable symposium “Holocaust***Gulag: Repressing, Rescuing, and Regulating Recalcitrant Legacies.” The symposium aimed at addressing specific aspects of the difficult and painful histories of the Holocaust and the Gulag, and to probe how these long-lasting legacies intrude into contemporary society, culture, religion, and politics.
Comparison of full fiber coupled interferometer systems under vacuum conditions
Authors: Meier Martin , Weichert Christoph , Kawohl Jan , Flügge Jens , Manske Eberhard 
Published: April 2024

Abstract
The PTB built a comparator setup for testing length measuring systems under vacuum conditions. The setup is equipped with a linear stage which is operated in a closed loop using the feedback of a 1.5D encoder system with three encoder heads for length and vertical rotation angle and exhibits a movement range of 150 mm. The main measurement system is a heterodyne interferometer with periodic nonlinearities with amplitudes below 10 pm. The comparator setup was characterized using a mirror mounted on the stage reflecting the measurement as well as the reference beams. By these means, the resolution, the stability of the setup as well as the influence of guiding errors on position-dependent measurement deviations of the fully fiber coupled interferometer were investigated. A position-depending error was observed which was resulting from the variation of the performance of the coupling into the multi-mode fibers used to transfer the superposed beams to the photoreceivers. The measured deviations were 1.5 nm or 0.2 nm over 70 mm travel range depending on the core diameter of the multi-mode fibers of 50 µm and 200 µm, respectively. Three different commercial fiber interferometer systems were analysed under vacuum conditions with the comparator setup. All tested systems are working with light sources with a wavelength of approximately 1535 nm but differ in the amplitude of their periodic nonlinearities in the range between 10 pm and 29 nm. The tests of their resolution and stability were limited by vibrations in the comparator setup and the lack of adequate synchronization capabilities of the data acquisition of these systems.
Resistivity and Piezoelectrical Behavior of the Smart Oil Well Cement Incorporated with Aluminum Oxide and Iron Oxide Nanoparticles—Experimental and Analytical Study
Authors: Vipulanandan C. , Mohammed Ahmed Salih , Piro Nzar Shakr 
Published: April 2024

Abstract
The effects of individually adding 1 % nano aluminum oxide (NA) and 1 % nano iron oxide (NF) on the curing, compressive piezoelectric, and stress-strain characteristics of cement (Class H) were studied and quantified. X-ray diffraction and thermogravimetric analysis were used to evaluate the cement (class H) with and without the 1 % NF and 1 % NA modification. The cement’s initial electrical resistivity (ER) incorporated with 0.1 % conductive filler was improved by 16 and 31 %, respectively, with 1 % NF and 1 % NA. Including 1 % NF and 1 % NA enhanced the stress at the failure of the cement paste by 26 and 39 % and 17 and 42 %, respectively, after curing times of 1 and 28 d. The nonlinear Vipulanandan p-q curing model was employed to anticipate ER change with curing age. Depending on the curing period and type of nanomaterial, the piezoelectrical (piezoresistivity) of “smart” cement containing NF and NA was more significant than normal cement by 500 times. The nonlinear curing model has been applied to model variations in ER with the curing period. The gauge factor model relating strain to resistivity changes under compressive stress was also developed using a relation model.
Characteristics of the Problems of a Patient with a Pituitary Tumour Treated Endoscopically through the Sphenoid Sinus
Authors: Królikowska Agnieszka , Birski Marcin , Ślusarz Robert 
Published: April 2024

Introduction. Pituitary tumours are usually benign adenomas. Surgical treatment is most often dedicated to patients with adenomas that cause symptoms of pressure, such as visual disturbances, headaches or symptoms resulting from hormonal disorders.
Aim. The aim of this study is to present the characteristic problems of a patient with pituitary macroadenoma who underwent endoscopic surgery through the sphenoid sinus.
Case Report. An individual case study of a 42-year-old man with pituitary macroadenoma who underwent surgical treatment through the sphenoid sinus is presented. The patient’s problem before neurosurgical treatment were headaches, which impaired his functioning. The postoperative period was uneventful, but required careful monitoring of the patient for cerebrospinal fluid leakage from the nose, diabetes insipidus and electrolyte disturbances.
Discussion. The case we analyzed required intensified multi-directional observation due to the risk of complications. After surgery, the patient was relatively quickly independent in everyday activities. Additionally, he required further support and education from the nursing team.
Conclusions. Endoscopic procedure through the nose and sphenoid sinus does not externally mutilate the patient, the postoperative wound is moved deep into the nose. The patient remains physically fit, quickly becomes independent in everyday activities, and requires little assistance from the nurse. Furthermore professional nursing observation of the patient after transsphenoidal endoscopic surgery allows detecting disturbing symptoms, enabling their early recognition and effective treatment. (JNNN 2023;12(4):170–176)
Rendering of Verbal and Verbal-Visual Puns in Lithuanian-Dubbed Animated Film “Mr. Peabody and Sherman”
Authors: Brasienė Brigita 
Published: April 2024

The rendering of verbal and verbal-visual puns in dubbing is a tough task that requires taking into account linguistic challenges, multimodal cohesion and dubbing synchronies. Thus, the aim of this research is to determine how verbal and verbal-visual puns are rendered from English into Lithuanian in the animated film Mr. Peabody & Sherman (2014). There have been collected 27 cases of puns including 14 verbal (52%) and 13 verbal-visual (48%) puns. The categorisation of verbal and verbal-visual puns according to the type revealed that verbal puns contained examples of homonymy, homophony and paronymy, but paronymic verbal puns prevailed the most. Almost all cases of verbal-visual puns were homonymic because of their intersemiotic construction which is usually based on polysemous words. All cases of verbal and verbal-visual puns have been rendered by employing 3 translation techniques: PUN→PUN, PUN→NON-PUN, PUN→PUNOID. The prevailing technique for transferring verbal and verbal-visual puns was PUN→PUN, which reveals the translator’s attempt to tackle linguistic challenges and consider multimodal cohesion and dubbing synchronies.
Porque a escribir se aprende escribiendo. Una propuesta para el aula de ELE Writing for learning to write / A proposal for the Spanish language classroom
Authors: Díez-Coronado Mª Ángeles 
Published: April 2024

Resumen La escritura es unade las destrezas que elestudiante de una L2 debemanejar. En las aulasnormalmente su enseñanzapasa por el conocimiento degramática y se vincula a élhasta el punto de sugerirse losejercicios de escritura casicompletamente en relación conla morfología o sintaxisestudiada. Esta metodología noprepara para la producciónescrita; afianza la gramática,pero deja de lado la formaciónpara producir textos creativos.Lo que se propone en esteartículo, tras una brevecontextualización, son unaserie de ejercicios que resultanútiles para desarrollar lacapacidad de la escritura enalumnos de L2 con cierta base. Abstract Writing is one of theskills that students of a L2 haveto know. Normally, it is inrelation with grammar, and thewriting exercises are useful foracquiring morphology orsyntax. But this methodologydoes not prepare for thecreative writing. In this article,after a brief contextualization,are proposed a series ofexercises that are useful fordeveloping the writing skillbetween students of a L2, whenthey are not beginners.
Metodologías activas. Un estudio de AICLE/CLIL en Tecnología e Inglés / Active Learning. A study of CLIC/AICLE in Technology and English
Authors: Warburton Susan 
Published: April 2024

Resumen: La importancia del idioma inglés para los alumnos universitarios hace necesario reforzar sus habilidades lingüísticas con el objetivo de que se conviertan en usuarios competentes en lengua inglesa. La finalidad de este trabajo es analizar el tipo de errores cometidos en la producción escrita durante el uso libre de la lengua inglesa, sin la realización de actividades gramaticales dirigidas. Para ello se utilizó la herramienta virtual Foro de la plataforma Moodle. Se planteó a los estudiantes una serie de cuestiones de carácter general relacionadas con noticias de actualidad en las que tuvieran que expresar su opinión en lengua inglesa. Se contabilizaron los errores cometidos por los alumnos y se analizaron los resultados obtenidos. Estos errores son en muchas ocasiones consecuencia de la inmediatez del discurso (los fallos de incorrección gráfica); fruto de estrategias de compensación en las que el alumno transfiere estructuras de su primera lengua a la segunda; y generalización de reglas gramaticales de la segunda lengua. El alumno no sólo necesita reforzar sus conocimientos gramaticales sino sistematizarlos a través de la práctica para así ir puliendo los errores cometidos.
Palabras clave: Foro; comunicación oral; análisis de errores; interlengua; inglés como segunda lengua.

Abstract: University students need to improve their language ability in English in order to become proficient language users. This paper aims to analyze the mistakes committed in the written domain during actual communication. An improvement in their performance in the grammar activities has been noticed but they still make mistakes when communicating without restrictions. The students were asked to debate and exchange opinions concerning current affairs in the news. The mistakes were recorded and analyzed. Different types were found: spelling mistakes consequence of the immediateness of the discourse exchange; mistakes as a result of compensation strategies using first language structures and generalization of grammar rules. Thus, students not only need to improve their knowledge of the rules but also to systematize it by practice in order to polish the mistakes committed.
Key words: Forum; Oral Communication; Error Analysis; Interlanguage; English as a second language.
El grado de determinación en la clasificación de los nominales: una experiencia en la escuela secundaria / The degree of determination in nominal classification: an experience in secondary school
Authors: Funes María Soledad , Poggio Anabella Laura 
Published: April 2024

Resumen:
Partiendo de los resultados obtenidos en Funes y Poggio (2015), estudio centrado en la enseñanza del nominal en la escuela secundaria desde el Enfoque Cognitivo-prototípico (ECP), el presente trabajo tiene como objetivo analizar la influencia del grado de determinación de los nombres en la categorización de los nominales que realizan los alumnos. Se sostienen las siguientes hipótesis: (1) a mayor grado de determinación, más facilidad en el reconocimiento de los nominales; sin embargo, (2) más allá del tipo de basamento (determinante), el contexto discursivo es fundamental para categorizar los nominales; 3) los nominales sin basamento se ubican en la zona intermedia del continuum categorial, ya que el plural y el significado colectivo se acercan a la indefinición. Para comprobar estas hipótesis, se realizaron pruebas a alumnos de primer año de una escuela privada de Buenos Aires (Argentina).
Palabras clave: Enfoque cognitivo-prototípico, gramática, enseñanza, nominal, determinación

Abstract:
Stemming from the results of Funes & Poggio (2015), our previous study on the teaching of the nominal in higher education, based on the Prototypical-cognitive approach, the present paper aims to analyse the influence of the degree of determination of nouns in the categorization of nominals by high school students. We hold the following hypothesis: (1) a higher degree of determination will allow students to identify more easily the nominals; however, (2) beyond the type of grounding, the discursive context is essential to categorize nominals; 3) nominals without grounding are located in the intermediate area of categorial continuum , as the plural nouns and collective nouns have meaning of indefiniteness. In order to prove these hypothesis, we have set tests to first year students (age: 13 years old) of a private high school in Buenos Aires (Argentina).
Key words: Cognitive-prototypical Approach, grammar, teaching, nominal, determination
α1-Antitrypsin deficiency
Authors: Karchevskaya N. A. , Belevskiy A. S. 
Published: April 2024

α1-Antitrypsin deficiency is classified as an orphan disease. The main target organs are the lungs, liver and skin. Typical respiratory manifestations are emphysema and bronchiectasis, which often lead to disability as the disease progresses. To slow the progression of lung pathology, replacement therapy with an α1-proteinase inhibitor is used worldwide.The aim of this article is to familiarize physicians with a rare lung disease that leads to the early development of emphysema and chronic obstructive pulmonary disease.Conclusion. Early detection of lung pathology associated with α1-antitrypsin deficiency allows timely prescription of the necessary replacement therapy, which in turn leads to an increase in the duration and improvement in the quality of life of patients with this pathology.
ChatGPT – a tool for assisted studying or a source of misleading medical information? AI performance on Polish Medical Final Examination
Authors: Żmudka Karol , Spychał Aleksandra , Ochman Błażej , Popowicz Łukasz , Piłat Patrycja , Jaroszewicz Jerzy 
Published: April 2024

WstępChatGPT jest modelem językowym stworzonym przez OpenAI, który może udzielać odpowiedzi na zapytania użytkownika, generując tekst na podstawie otrzymanych danych. Celem pracy była ocena wyników działania ChatGPT na polskim Lekarskim Egzaminie Końcowym (LEK) oraz czynników wpływających na odsetek prawidłowych odpowiedzi. Ponadto zbadano zdolność chatbota do podawania poprawnego i wnikliwego wyjaśnienia.Materiał i metodyWprowadzono 591 pytań z dystraktorami z bazy LEK do interfejsu ChatGPT (wersja 13 lutego – 14 marca). Porównano wyniki z kluczem odpowiedzi i przeanalizowano podane wyjaśnienia pod kątem logicznego uzasadnienia. Dla poprawnych odpowiedzi przeanalizowano spójność logiczną wyjaśnienia, natomiast w przypadku odpowiedzi błędnej obserwowano zdolność do poprawy. Wybrane czynniki zostały przeanalizowane pod kątem wpływu na zdolność chatbota do udzielenia poprawnej odpowiedzi.WynikiChatGPT osiągnął imponujące wyniki poprawnych odpowiedzi na poziomie: 58,16%, 60,91% i 67,86%, przekraczając oficjalny próg 56% w trzech ostatnich egzaminach. W przypadku poprawnie udzielonych odpowiedzi ponad 70% pytań zostało popartych logicznie spójnym wyjaśnieniem. W przypadku błędnych odpowiedzi w 66% przypadków chatbot podał pozornie poprawne wyjaśnienie dla nieprawidłowych odpowiedzi. Czynniki takie jak konstrukcja logiczna (p < 0,05) i wskaźnik trudności zadania (p < 0,05) miały wpływ na ogólną ocenę, podczas gdy liczba znaków (p = 0,46) i język (p = 0,14) takiego wpływu nie miały.WnioskiMimo iż ChatGPT osiągnął wystarczającą liczbę punktów, aby zaliczyć LEK, w wielu przypadkach podawał wprowadzające w błąd informacje poparte pozornie przekonującym wyjaśnieniem. Chatboty mogą być szczególnym zagrożeniem dla użytkownika niemającego wiedzy medycznej, ponieważ w porównaniu z wyszukiwarką internetową dają natychmiastowe, przekonujące wyjaśnienie, co może stanowić zagrożenie dla zdrowia publicznego. Z tych samych przyczyn ChatGPT powinien być ostrożnie stosowany jako pomoc naukowa.
Análisis de la modulación multiplexación por división de frecuencia generalizada
Authors: Blanco-Orta Jorge Luis , Guerra-Martínez María del Carmen , Marante-Rizo Francisco Reinerio 
Published: April 2024

En el presente artículo se hace una investigación de la modulación Multiplexación por División de Frecuencia Generalizada (GFDM) y su influencia para mejorar la estructura de la capa física, teniendo en cuenta las ventajas inherentes que presenta para el desarrollo de nuevas tecnologías. Se establece una comparación con la modulación Multiplexación por División de Frecuencia Ortogonal (OFDM), utilizada en la comunicación móvil de cuarta generación (4G). Definiendo las características que diferencian a cada una de las señales, así como los beneficios para la arquitectura de red, las tecnologías habilitadoras y por ser una modulación que puede solucionar problemas en sistemas masivos de múltiples entradas y múltiples salidas (MIMO). La investigación se realiza con el propósito de lograr una mayor transmisión de datos, por ser esta una tecnología clave, que afrontará problemas similares en futuros sistemas y mejorar la flexibilidad de la sexta generación (6G).
Evolução da produção científica sobre o Mercado Eficiente: Estudo bibliométrico
Authors: Moraes Alexandra Kelly de , Furtini Andressa Aparecida Santana , Prado José Willer do , Castro Junior Luiz Gonzaga de , Ceretta Paulo Sergio 
Published: April 2024

Contextualização: O texto destaca a importância da Eficiência de Mercado no ambiente dinâmico e complexo do mercado, que tem sido amplamente estudada e analisada. A abordagem desse tema desperta interesse no meio acadêmico e tem sido objeto de diversos estudos.
Objetivo: O estudo tem como objetivo mapear a produção científica relacionada ao conceito de Mercado Eficiente, analisando a evolução dos trabalhos acadêmicos e pesquisas sobre o tema ao longo do tempo.
Método: A pesquisa adota uma abordagem descritiva com enfoque quantitativo e análise bibliométrica para mensurar os índices de produtividade científica em um tema específico. Foram identificados 478 artigos relevantes nas bases de dados do Web of Science e Scopus no período de 1977 a 2023. Os softwares EndNote e Bibliometrix R foram utilizados para análise, seguida pela elaboração de tabelas e gráficos estatísticos para apresentação nos softwares Biblioshiny e VOSviewer.
Resultados: A análise dos dados revelou um aumento constante nas publicações no campo das finanças relacionadas ao tema, com destaque para periódicos específicos. As afiliações dos periódicos se concentraram principalmente nas regiões da América, Europa e Ásia, em áreas como estatística, economia, negócios e gestão. Referências importantes e temas abordados incluíram eficiência de mercado, finanças comportamentais e eficiência do mercado de ações. Eugene Fama foi destacado como o autor mais influente. Quanto às tendências futuras, áreas como análise da eficiência de mercado, gestão de risco e previsibilidade em períodos de conflitos globais foram identificadas, requerendo métodos complexos e inovadores.
Conclusões: Esses resultados contribuem para a ampliação do conhecimento e entendimento sobre eficiência de mercado, incentivando a busca por abordagens inovadoras e complexas para avançar ainda mais nesse campo de estudo.
STUDIO KOMIK AGORA DI BANJARABRU
Authors: Annada Katrun , Sarbini Gusti Novi 
Published: April 2024

The Agora Comics Studio in Banjarbaru is a studio building that is not only a place for drawing but also a place that provides a gathering place for the community to enjoy comics with various activities. By applying comic elements into the building as a place to make the story in three dimensions and the people in it are indirectly involved as characters for their own stories. The application of the methods of superimpose theories can solve problems and provide design ideas. Resulting in a 3D Story concept which became the idea of ​​the Agora Comic Study building in Banjarbaru.
PERPUSTAKAAN KOLABORATIF (MAKERSPACE LIBRARY) DI BANJARBARU
Authors: Bilah Muhammad El'Arif , Andini Dila Nadya 
Published: April 2024

The library in Banjarbaru is still considered as nothing more than a place to read books and the books themselves are only old book collections, this creates a stigma that libraries do not develop according to the needs of people who are too dependent on digitalization and technology. This is the underlying reason why people lack interest in visiting the library. Therefore, it is necessary to develop a library as a new face of public space that can accommodate activities for collaboration and offer social networks for the Banjarbaru community. The purpose of designing a Collaborative Library (Makerspace Library) in Banjarbaru is to create an educated, accustomed to reading, and highly cultured community. Through the library, people can exchange information and knowledge.