bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tuning of ultraviolet‐curable ink printability via in situ ultraviolet irradiation during direct ink write applications
Authors: Jackson Sean , Zaragoza Lysette , Kumar Balaji Krisna , Dickens Tarik 
Published: March 2024

AbstractDirect ink write deposition facilitates line‐by‐line extrusion of inks spanning wide viscoelastic ranges. Following deposition, post processing technologies permit tuning of the extrudate's material property characteristics—ultraviolet (UV) irradiation, facilitating the photopolymerization of UV‐reactive catalyst solutions, permits targeted modification of the extrudate's microstructure and in situ tuning of extrudate macrostructure. This report analyzes the morphological, rheological, and microstructural property relationships governing the printability, and processivity, of extruded UV‐curable resin inks for delineation of sufficiency and optimization of ink printability utilizing direct ink write technologies. A design‐of‐experiments approach is implemented to quantify significance regarding an extrudate's dimensional response to extrusion parameter variation and in situ processing parameters, identifying proportionally of nozzle velocity, nozzle height, and UV irradiation exposure with extrudate aspect ratio, reflected by respective maximum extrudate aspect ratio increases of 158% and 109%, regarding 121 and 123K resin inks. Finally, the relationship between extrudate morphology and microstructure variation was assessed via dielectric cure monitoring, whereby an extrudate's ion viscosity was calculated in relation to its rheological modulus, reflecting the relationship between an extrudate's morphology, rheological response, and printability, regarding its microstructural variation.
Winning conditions for evading into a circular region with speed advantage
Authors: Zhou Shaobo , Li Huiping , Wang Keyang , Huang Panfeng , Sun Changyin 
Published: March 2024

AbstractIn this study, we consider a two‐player pursuit‐evasion game in which an evader attempts to evade into a circular region while a pursuer along the boundary of this region aims at intercepting the evader. The evader is considered to possess a higher speed than that of the pursuer, which makes this study different from the existing ones. Both the players are assumed to have constant speeds and simple motions; that is, they can change their moving directions instantaneously. The sufficient conditions for the evader to win the game against the pursuer with a zero capture radius or a positive capture radius are proposed using geometric methods. In addition, both the evading strategies under the corresponding derived conditions against the pursuer are developed.
Harnessing the Potential of Zn Powder Anodes: Innovations and Future Directions in Aqueous Zinc‐Ion Batteries
Authors: Liu Dongshu , Xu Xilian , Meng Shibo , Li Jun , Feng Jinxiu , Chen Yuchao , Liu Wenxian , Wu Fangfang , Shi Wenhui , Cao Xiehong 
Published: March 2024

AbstractThe pursuit of alternative anode materials featuring inexpensive, efficient, and adaptable is shaping the future of rechargeable zinc‐ion batteries. The Zn powder anodes stand out among contenders due to their cost‐effectiveness, exceptional processability, and adjustability. However, their widespread use is hampered by significant challenges, including volume expansion and dendrite growth. To counter these issues, a gamut of optimization strategies for Zn powder anodes has been explored and developed. This review systematically encapsulates these research findings, offering a comprehensive understanding of various enhancement methods, such as three‐dimensional printing, in‐situ surface engineering, scalable electrostatic self‐assembly, and epoxy oligomer binding. These methodologies are discussed in detail in the context of their unique synthesis methods and underlying mechanisms. The paper concludes by outlining prospective research trajectories aimed at further optimizing the use of Zn powder anodes in aqueous zinc‐ion batteries, thereby illuminating potential avenues for future exploration and development.
The synthesis and properties of Ca3Sc2Si3O12:Ce3+ (CSSG) phosphor are utilized for the development of human‐centric lighting light‐emitting diodes (HCL‐LEDs)
Authors: Lan Nguyen Mai Cao Hoang Phuong , Thang Cao Xuan , Viet Dao Xuan , Tung Nguyen Viet , Kien Nguyen Duc Trung 
Published: March 2024

AbstractIn this study, cerium ion (Ce3+)‐doped calcium scandium silicate garnet (Ca3Sc2Si3O12, abbreviated CSSG) phosphors were successfully synthesized using the sol–gel method. The crystal phase, morphology, and photoluminescence properties of the synthesized phosphors were thoroughly investigated. Under excitation by a blue light‐emitting diode (LED) chip (450 nm), the CSSG phosphor displayed a wide emission spectrum spanning from green to yellow. Remarkably, the material exhibited exceptional thermal stability, with an emissivity ratio at 150°C to that at 25°C reaching approximately 85%. Additionally, the material showcased impressive optical performance when tested with a blue LED chip, including a color rendering index (CRI) exceeding 90, an R9 value surpassing 50, and a biological impact ratio (M/P) above 0.6. These noteworthy findings underscore the potential applications of CSSG as a white light‐converting phosphor, particularly in the realm of human‐centered lighting.
Comprehensive analysis indicated that NDE1 is a potential biomarker for pan‐cancer and promotes bladder cancer progression
Authors: Wang Peihan , Ning Jinzhuo , Chen Wu , Zou Fan , Yu Weimin , Rao Ting , Cheng Fan 
Published: March 2024

AbstractBackgroundThe nuclear distribution E homologue 1 (NDE1) is a crucial dynein binding partner. The NDE1 protein has the potential to disrupt the normal functioning of centrosomes, leading to a compromised ability to generate spindles and ensure precise separation of chromosomes during cell division. The potential consequences of this phenomenon include genomic instability, malignant transformation and the proliferation of neoplastic growths. However, studies examining the connection between NDE1 and cancer is still very rare.MethodsThe expression level, prognostic impact, gene change, DNA methylation, protein interaction, mRNA m6A modification, ceRNA network, associated gene and function enrichment, and immune‐related effects of NDE1 in pan‐cancer were examined using a range of online analytic tools and the R software package. The CCK‐8 test, transwell assay, scratch assay and colony formation assay were used to confirm the effects of NDE1 on the proliferation, invasion and metastasis of bladder cancer cells.ResultsNumerous tumour types have elevated NDE1, which is linked to a bad prognosis. NDE1 is an excellent diagnostic tool for many different types of cancer. Numerous malignancies have been linked to genetic changes in NDE1. NDE1 was connected to TMB, MSI, several immunological checkpoint genes and immune cell infiltration. NDE1 is linked to a number of immunological subtypes. NDE1 could affect how well immunotherapy works to treat different types of cancer. NDE1 was mostly associated with cell cycle, chromosomal segregation, DNA replication and mitotic segregation, according to GO and KEGG analyses. NDE1 physically binds to PAFAH1B1 and DCTN1, respectively. The proliferation, invasion and metastasis of bladder cancer cells may be prevented by NDE1 knockdown. Furthermore, knockdown of NDE1 promoted the apoptosis of bladder cancer cells.ConclusionHigh expression of NDE1 is present in a variety of tumours, which is linked to a bad prognosis for cancer. Knockdown of NDE1 inhibited the proliferation, invasion and metastasis of bladder cancer cells, and promoted the apoptosis. For a number of malignancies, NDE1 may be a biomarker for immunotherapy and prognosis.
High TPX2 expression results in poor prognosis, and Sp1 mediates the coupling of the CX3CR1/CXCL10 chemokine pathway to the PI3K/Akt pathway through targeted inhibition of TPX2 in endometrial cancer
Authors: Yang Mei , Mao Xiaogang , Li Lin , Yang Jiang , Xing Hui , Jiang Chunfan 
Published: March 2024

AbstractIntroductionApproximately 30% of individuals with advanced EC have unsatisfactory prognosis. Evidence suggests that TPX2 is frequently upregulated in malignancies and related to cancer progression. Its role and pathological mechanism in EC need further research.MethodsGSEA and TPX2 expression, GO, KEGG, and prognostic analyses were performed with TCGA data by bioinformatic approaches. Relationships between TPX2 expression and clinicopathological parameters were investigated immunohistochemically and statistically. shRNA and overexpression plasmids were constructed and transfected into AN3CA and Ishikawa cells to evaluate phenotypic changes and injected into nude mouse axillae. Coimmunoprecipitation and chromatin immunoprecipitation were used to identify interacting proteins and promoter‐binding sequences. Changes in TPX2 expression were identified by Western blotting and RT–qPCR.ResultsTPX2 expression was significantly higher in EC tissues than in normal tissues in TCGA and in‐house specimens (all p < 0.001). In survival analysis, high TPX2 expression was associated with poor prognosis (p = 0.003). TPX2 overexpression stimulated cancer cell proliferation, promoted the G0‐G1‐to‐G2/M transition, enhanced invasion and migration, and accelerated tumor growth in nude mice. TPX2 regulated the CX3CR1/CXCL10 chemokine pathway and activated the PI3K/Akt signaling pathway. Sp1 negatively regulated TPX2 expression, affecting the malignant progression of endometrial cancer cells by coupling the CX3CR1/CXCL10 chemokine pathway to the PI3K/Akt signaling pathway.ConclusionTPX2 could be a prognostic biomarker for EC and play an important role in the CX3CR1/CXCL10 chemokine pathway and PI3K/Akt pathway via Sp1.
Incidence of skeletal‐related events in patients with Ewing sarcoma: An observational retrospective study in Japan
Authors: Aiba Hisaki , Kojima Yuki , Shimoi Tatsunori , Sudo Kazuki , Yazaki Shu , Imai Toru , Yoshida Akihiko , Iwata Shintaro , Kobayashi Eisuke , Kawai Akira , Arakawa Ayumu , Ogawa Chitose , Kimura Hiroaki , Yonemori Kan 
Published: March 2024

AbstractBackgroundSkeletal‐related events (SREs), including the pathological fracture, surgical treatment or radiation of bone lesions, malignant spinal cord compression, hypercalcemia, are important considerations when managing metastatic bone tumors; however, owing to their rarity, the incidence of SREs in patients with Ewing sarcoma remains unknown.MethodsWe retrospectively reviewed the clinical data from 146 patients with Ewing sarcoma treated at a single institution from 2005 to 2019. The median age at diagnosis was 22.7 years. Fifty patients (34.2%) had metastatic disease at diagnosis. The primary outcome was the SRE‐free rate among patients with Ewing sarcoma. Moreover, we identified the risk factors for SREs using univariate or multivariate analyses.ResultsDuring the observational period (median, 2.6 years), SREs occurred in 23 patients. Radiation to the bone, malignant spinal cord compression, and hypercalcemia were documented as the initial SREs in 12 patients (52.2%), 10 patients (43.5%), and one patient (4.3%), respectively. The SRE‐free rate was 94.2 ± 2.0, 87.3 ± 3.0, and 79.6 ± 3.8% at 1, 2, and 3 years after the initial visit, respectively. Multivariate analysis revealed bone metastasis at diagnosis (hazard ratio [HR] = 4.41, p = 0.007), bone marrow invasion (HR = 34.08, p < 0.001), and local progression or recurrence after definitive treatment (HR = 3.98, p = 0.012) as independent risk factors for SREs.ConclusionsSREs are non‐rare events that can occur during the treatment course for Ewing sarcoma, with an especially high incidence of malignant spinal cord compression. Patients with metastatic disease at diagnosis, especially in the bone or bone marrow, or with local progression or recurrence after definitive treatment, should be carefully monitored for the occurrence of SREs. The most effective methods to monitor the occurrence of SREs and new preventative therapies for SREs should be investigated in the future.
Psychometric validation of the Functional Assessment of Cancer Therapy‐Endometrial among endometrial cancer patients
Authors: Kim Sooyeon , Noh Joseph J. , Kim Youngha , Cho Juhee , Kang Danbee , Lee Yoo‐Young 
Published: March 2024

AbstractObjectiveTo evaluate a psychometric validation of the endometrial cancer subscales (EnCS) in the Functional Assessment of Cancer Therapy‐Endometrial (FACT‐EN) among patients with endometrial cancer.MethodsThis cross‐sectional study was conducted at a tertiary university‐based hospital in South Korea between April and October 2022. Participants completed a survey questionnaire that included the FACT‐EN. Exploratory and confirmatory factor analyses (EFA, CFA) and the reliability were measured using the intraclass correlation coefficient (ICC) under a two‐way mixed model. Pearson's correlations were used to evaluate the validity. We also tested known‐group validity.ResultsIn total, 240 patients with endometrial cancer participated in the survey. In EFA, we found EnCS included four domains. In CFA, four‐factor solution model was good: CFI = 0.659; SRMR = 0.066, and RMSEA = 0.073. The mean (SD) of total score of FACT‐EN was 122.84 (23.58). The floor and ceiling effects were 0.4% and 0.4%, respectively. Cronbach's α coefficients for the five scales of the EnCS ranged from 0.78 to 0.91. The ICC of EnCS was 0.76. The convergent and discriminant validity of EnCS was acceptable. In the group analysis, older age and lower ECOG performance scores were associated with higher EnCS scores. The stomach and vaginal domains in EnCS were higher in patients who had completed treatment for more than 1 year compared to those who were still undergoing treatment.ConclusionsFACT‐EN has demonstrated its validity as an assessment tool with significant implications for capturing various symptoms in patients with endometrial cancer.
Strategies for the Construction of Multicyclic Phage Display Libraries
Authors: Chen Fa‐Jie , Pinnette Nicole , Gao Jianmin 
Published: March 2024

AbstractPeptide therapeutics have gained great interest due to their multiple advantages over small molecule and antibody‐based drugs. Peptide drugs are easier to synthesize, have the potential for oral bioavailability, and are large enough to target protein‐protein interactions that are undruggable by small molecules. However, two major limitations have made it difficult to develop novel peptide therapeutics not derived from natural products, including the metabolic instability of peptides and the difficulty of reaching antibody‐like potencies and specificities. Compared to linear and disulfide‐monocyclized peptides, multicyclic peptides can provide increased conformational rigidity, enhanced metabolic stability, and higher potency in inhibiting protein‐protein interactions. The identification of novel multicyclic peptide binders can be difficult, however, recent advancements in the construction of multicyclic phage libraries have greatly advanced the process of identifying novel multicyclic peptide binders for therapeutically relevant protein targets. This review will describe the current approaches used to create multicyclic peptide libraries, highlighting the novel chemistries developed and the proof‐of‐concept work done on validating these libraries against different protein targets.
3D Carbonaceous Foams Derived from High Internal Phase Emulsion for Energy Applications
Authors: Jouanne C. , Pham‐Truong T. N. , Vancaeyzeele C. , Muya F. N. , Pokpas K. , Baker P. G. L. , Aubert P. H. 
Published: March 2024

AbstractIn recent years, there has been a notable increase in interest regarding monolithic porous polymers known as poly(High Internal Phase Emulsion) – poly(HIPE) – which are synthesized from high internal phase emulsions. This is due to their exceptional capability to produce three‐dimensional structures with substantial porosity. Nevertheless, the exploitation of this family of materials in energy‐driven applications is still limited, mainly because of their lack of conductivity. The exploration of conducting materials with 3D polymeric frameworks remains a promising avenue for research. In this context, pyrolysed poly(HIPE) seems to be the simplest and most cost‐effective strategy to directly transform a 3D polymer into a 3D conductive carbon foam, that is, carboHIPE. Currently, CarboHIPE and its derivatives are becoming alternatives to commercially available activated carbon/graphite or expensive graphene and carbon nanotube‐based materials. Accordingly, gaining insight into the formation of these materials is crucial to accelerate their use in commercial energy devices. This review aims to provide a comprehensive summary of various synthesis pathways utilized to modify the characteristics of CarboHIPEs, as well as the recent developments in their application as active components in energy‐based systems.
In situ Diazonium Salt Formation and Photochemical Aryl‐Aryl Coupling in Continuous Flow Monitored by Inline NMR Spectroscopy
Authors: Deckers Christoph , Rehm Thomas H. 
Published: March 2024

AbstractA novel class of diazonium salts is introduced for the photochemical aryl‐aryl coupling to produce (substituted) biphenyls. As common diazonium tetrafluoroborate salts fail, soluble and safe aryl diazonium trifluoroacetates are applied. In this mild synthesis route no catalysts are required to generate an aryl‐radical by irradiation with UV‐A light (365 nm). This reactive species undergoes direct C−H arylation at an arene, forming the product in reasonable reaction times. With the implementation of a continuous flow setup in a capillary photoreactor 13 different biphenyl derivatives are successfully synthesized. By integrating an inline 19F‐NMR benchtop spectrometer, samples are reliably quantified as the fluorine‐substituents act as a probe. Here, real‐time NMR spectroscopy is a perfect tool to monitor the continuously operated system, which produces fine chemicals of industrial relevance even in a multigram scale.
Scope and Limitations of Using Microemulsions for the Covalent Patterning of Graphene
Authors: Naranjo Alicia , Garrido Marina , Martín Sabanés Natalia , Pérez Emilio M. 
Published: March 2024

AbstractPatterning of graphene (functionalizing some areas while leaving others intact) is challenging, as all the C atoms in the basal plane are identical, but it is also desirable for a variety of applications, like opening a bandgap in the electronic structure of graphene. Several methods have been reported to pattern graphene, but most of them are very technologically intensive. Recently, we reported the use of microemulsions as templates to pattern graphene at the μm scale. This method is very simple and in principle tunable, as emulsions of different droplet size and composition can be prepared easily. Here, we explore in detail the scope of this methodology by applying it to all the combinations of four different emulsions and three different organic reagents, and characterizing the resulting substrates exhaustively through Raman, SEM and AFM. We find that the method is general, works better when the reactive species are outside the micelles, and requires reactive species that involve short reaction times.
Nlmixr2 Versus NONMEM: An Evaluation of Maximum A Posteriori Bayesian Estimates Following External Evaluation of Gentamicin and Tobramycin Population Pharmacokinetic Models
Authors: Duong Alexandre , Marsot Amélie 
Published: March 2024

AbstractThe objective of this project is to compare the results of the same study carried out on NONMEM and nlmixr2. This analysis consists of evaluating previously published population pharmacokinetic models of gentamicin and tobramycin in our population of interest with sparse concentrations. A literature review was performed to determine the gentamicin and tobramycin models in critically ill adult patients. In parallel, gentamicin and tobramycin dosing data, information on the treatment, the patient, and the bacteria were collected retrospectively in 2 Quebec establishments. The external evaluations were previously performed using NONMEM Version 7.5. Model equations were rewritten with R, and external evaluations were performed using nlmixr2. Predictive performance was assessed based on the estimation of bias and imprecision of the prediction error for maximum a posteriori (MAP) Bayesian PK parameter and observed concentrations. Comparison between nlmixr2 and NONMEM was performed on 4 gentamicin and 3 tobramycin population pharmacokinetic models. Compared to NONMEM, for gentamicin and tobramycin clearance and central volume of distribution, nlmixr2 produced individual pharmacokinetic parameters with bias values ranging from −32.5% to 5.67% and imprecision values ranging from 6.33% to 32.5%. Despite these differences, population bias and imprecision for sparse concentrations were low and ranged from 0% to 5.3% and 0.2% to 6.5%, respectively. The external evaluations performed with both software packages resulted in the same interpretation in terms of population predictive performance for all 7 models. Nlmxir2 showed comparable predictive performance with NONMEM with sparse concentrations that are, at most, sampled twice within a single dose administration (peak and trough).
Isolation and Culturing of Primary Murine Chondroprogenitor Cells: A Mammalian Model of Chondrogenesis
Authors: Vágó Judit , Somogyi Csilla , Takács Roland , Barna Krisztina Bíróné , Jin Eun‐Jung , Zákány Róza , Matta Csaba 
Published: March 2024

AbstractEmbryonic limb bud‐derived micromass cultures are valuable tools for investigating cartilage development, tissue engineering, and therapeutic strategies for cartilage‐related disorders. This collection of fine‐tuned protocols used in our laboratories outlines step‐by‐step procedures for the isolation, expansion, and differentiation of primary mouse limb bud cells into chondrogenic micromass cultures. Key aspects covered in these protocols include synchronized fertilization of mice (Basic Protocol 1), tissue dissection, cell isolation, micromass formation, and culture optimization parameters, such as cell density and medium composition (Basic Protocol 2). We describe techniques for characterizing the chondrogenic differentiation process by histological analysis (Basic Protocol 3). The protocols also address common challenges encountered during the process and provide troubleshooting strategies. This fine‐tuned comprehensive protocol serves as a valuable resource for scientists working in the fields of developmental biology, cartilage tissue engineering, and regenerative medicine, offering an updated methodology for the study of efficient chondrogenic differentiation and cartilage tissue regeneration. © 2024 The Authors. Current Protocols published by Wiley Periodicals LLC.Basic Protocol 1: Synchronized fertilization of miceBasic Protocol 2: Micromass culture of murine embryonic limb bud‐derived cellsBasic Protocol 3: Qualitative assessment of cartilage matrix production using Alcian blue staining
Recycling of Spent FCC Catalysts: Conversion of Leached Residues to Zeolite ZSM‐5
Authors: Timoshev Vladislav , Haufe Liane A. , Busse Oliver , Hamedi Homa , Seifert Markus , Weigand Jan J. 
Published: March 2024

AbstractThe commercial recycling of spent FCC catalyst typically focuses on recovering only 1–3 % of rare‐earth elements, with the remaining residues often disposed of in landfills. Here, we present a novel method to close a recycling loop for spent FCC catalyst. The method involves a series of leaching steps: Firstly, the spent catalyst material is leached with HNO3 to remove rare‐earth elements such as La; second, solvothermal leaching with HCl removes most of Al and impurities like Fe, Ni and V; finally, a third leaching with H2SO4 removes Ti. The solid residues are then used to synthesize ZSM‐5 without the addition of any extra silicon or aluminum sources after mild activation. The impurities in the synthesis gel strongly modify the properties of the zeolite, with ZSM‐5 crystals containing higher levels of impurities exhibiting lower crystallinities, surface areas, acidities, cracking activities, as well as larger particle sizes.