bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between nocturnal blood pressure phenotype and adverse cardiovascular prognosis in patients with coronary heart disease and hypertension
Authors: Du Yao , Zhu Binbin , Liu Yahui , Zhou Weicen , Du Zhou , Yang Wei , Gao Chuanyu 
Published: March 2024

AbstractNocturnal blood pressure and nighttime dipping patterns are associated with the occurrence of cardiovascular events. However, there is few research on whether riser pattern is associated with the poor prognosis of patients with coronary heart disease (CHD) and hypertension independent of nighttime systolic blood pressure (SBP). This prospective and observational clinical study included 568 hospitalized patients with CHD and hypertension. All patients underwent 24‐h ambulatory blood pressure (BP) monitoring during their hospitalization. Multivariate adjusted Cox proportional hazard models were utilized to examine the associations of nocturnal blood pressure and dipping status with primary endpoint events. Additionally, Harrell's C‐statistics were employed to compare the discriminative ability of each model. During the 1‐year follow‐up period, 64 (11.3%) primary endpoint events were recorded, including 55 (9.7%) atherosclerotic cardiovascular disease (ASCVD) events. After adjusting for demographic and clinical risk variables, nighttime SBP was significantly related to the risk of incident primary endpoint events [per 20 mm Hg increase: hazard ratio (HR) = 1.775, 95% confidence interval (CI) 1.256–2.507]. The riser pattern group exhibited a significantly higher risk for primary endpoint events compared to the dipper pattern group, even after adjusting for office SBP (HR: 2.687, 95% CI: 1.015–7.110, p = .047). Furthermore, the addition of nighttime SBP or dipping status to the base model yielded statistically significant increments in C‐statistic values (p = .036 and p = .007). However, adding both nighttime SBP and dipping status did not significantly enhance the model's performance in predicting the risk of primary endpoint events and ASCVD events according to the C‐index (p = .053 and p = .054), which meant that the riser pattern group did not exhibit a significantly higher risk for primary endpoint events compared to the dipper pattern group after adjusting for nighttime SBP. In conclusion, nocturnal SBP and riser pattern demonstrated an association with adverse prognosis in patients with CHD and hypertension. Notably, nocturnal SBP proved to be a more reliable predictor than dipping status.
European consensus‐based interdisciplinary guideline for diagnosis, treatment and prevention of actinic keratoses, epithelial UV‐induced dysplasia and field cancerization on behalf of European Association of Dermato‐Oncology, European Dermatology Forum, European Academy of Dermatology and Venereology and Union of Medical Specialists (Union Européenne des Médecins Spécialistes)
Authors: Kandolf Lidija , Peris Ketty , Malvehy Josep , Mosterd Klara , Heppt Markus V. , Fargnoli Maria Concetta , Berking Carola , Arenberger Petr , Bylaite‐Bučinskiene Matilda , del Marmol Veronique , Dirschka Thomas , Dreno Brigitte , Forsea Ana‐Maria , Harwood Catherine A. , Hauschild Axel , Heerfordt Ida Marie , Kauffman Roland , Kelleners‐Smeets Nicole , Lallas Aimilios , Lebbe Celeste , Leiter Ulrike , Longo Caterina , Mijušković Željko , Pellacani Giovanni , Puig Susana , Saiag Philippe , Šitum Mirna , Stockfleth Eggert , Salavastru Carmen , Stratigos Alexander , Zalaudek Iris , Garbe Claus ,   European Association of Dermato‐Oncology, European Dermatology Forum, European Academy of Dermatology and Venereology and Union of Medical Specialists (Union Européenne des Médecins Spécialistes)
Published: March 2024

AbstractA collaboration of multidisciplinary experts from the European Association of Dermato‐Oncology, the European Dermatology Forum, the European Academy of Dermatology and Venereology, and the European Union of Medical Specialists was formed to develop European recommendations on AK diagnosis and treatment, based on current literature and expert consensus. This guideline addresses the epidemiology, diagnostics, risk stratification and treatments in immunocompetent as well as immunosuppressed patients. Actinic keratoses (AK) are potential precursors of cutaneous squamous cell carcinoma (cSCC) and display typical histopathologic and immunohistochemical features of this malignancy in an early stage. They can develop into cSSC in situ and become invasive in a low percentage of cases. AK is the most frequent neoplasia in white populations, frequently occurring within a cancerous field induced by ultraviolet radiation. Since it cannot be predicted, which lesion will progress to cSCC and when treatment is usually recommended. The diagnosis of AK and field cancerization is made by clinical examination. Dermatoscopy, confocal microscopy, optical coherence tomography or line‐field confocal‐OCT can help in the differential diagnosis of AK and other skin neoplasms. A biopsy is indicated in clinically and/or dermatoscopically suspicious and/or treatment‐refractory lesions. The choice of treatment depends on patients' and lesion characteristics. For single non‐hyperkeratotic lesions, the treatment can be started upon patient's request with destructive treatments or topical treatments. For multiple lesions, field cancerization treatment is advised with topical treatments and photodynamic therapy. Preventive measures such as sun protection, self‐examination and repeated field cancerization treatments of previously affected skin areas in high‐risk patients are advised.
Clinical course of small gastric subepithelial lesion less than 20 mm diagnosed by endoscopic ultrasound‐guided fine‐needle aspiration
Authors: Kobayashi Ryosuke , Hirasawa Kingo , Ozeki Yuichiro , Sawada Atsushi , Nishio Masafumi , Sato Chiko , Miwa Haruo , Kaneko Takashi , Sugimori Kazuya , Maeda Shin 
Published: March 2024

AbstractBackground and AimGastrointestinal stromal tumors (GISTs) are treated as malignant gastric subepithelial lesions (SELs), and resection is recommended. However, small gastric SELs < 20 mm with no malignant features are monitored without histopathological examination, and the frequency of malignancy is unknown. This study aimed to clarify the clinicopathological findings and clinical course of gastric SELs < 20 mm measured by endoscopic ultrasound (EUS).MethodsThis retrospective cohort study included consecutive patients with small gastric SELs < 20 mm diagnosed using EUS at a tertiary referral center between 2009 and 2021. The clinical course after diagnosis using EUS‐guided fine‐needle aspiration (EUS‐FNA) was reviewed.ResultsAmong 333 patients with small gastric SELs, 104 patients with 105 lesions underwent EUS‐FNA. The pathological diagnosis was confirmed in 87 patients. GISTs were the most common pathology (47%). Among the 87 patients, 43 underwent therapeutic interventions, including tumor resection and chemotherapy. In groups of tumor resection, the pathological tumor size on the resected specimen was significantly larger than the size measured by EUS (19.5 mm vs 15.0 mm, P < 0.001), and 37% of resected SELs were 20 mm or over. No recurrence was observed after tumor resection during a mean follow‐up period of 40 months.ConclusionsApproximately 40% of small gastric SELs were malignant tumors, such as GIST, with most of them requiring treatment. Additionally, considering that the EUS measurement is 5 mm smaller than the pathological tumor diameter, further examinations, such as systematic EUS‐FNA, may be required for SEL, including those smaller than 20 mm.
Price Stickiness Heterogeneity and Equilibrium Determinacy
Authors: LEE JAE WON , PARK WOONG YONG 
Published: March 2024

AbstractMonetary policy can achieve equilibrium determinacy with considerably weak responses to inflation under price stickiness heterogeneity. The result holds in a sticky‐price model with the constant elasticity‐of‐substitution aggregator and no trend inflation, and with a variable elasticity‐of‐substitution aggregator and historical trend inflation. The evidence in favor of the view that the U.S. economy was subject to self‐fulfilling expectations‐driven fluctuations in the pre‐Volcker period and the systematic shift in monetary policy was crucial in subsequent stabilization of inflation appears much weaker through the lens of price stickiness heterogeneity than previously concluded in the literature under price stickiness homogeneity.
The potential of Paeonia lactiflora pall seeds oil as a pure natural cosmetics raw material: In Vitro findings
Authors: Chen Zhixiong , Hong Ni , Yan Cui , Zheng Zhongbo , Xi Jie , Cao Ping 
Published: March 2024

AbstractBackgroundAs a traditional Chinese herbal medicine, Paeonia lactiflora Pall is rich in various active ingredients such as polysaccharides and total flavonoids while having ornamental value. It has potential application value in the development of food and cosmetics.ObjectiveTo study the in vitro efficacy of Paeonia lactiflora Pall seeds oil.MethodsFirstly, the levels of linolenic acid and linoleic acid in Paeonia lactiflora Pall seeds oil were quantified using gas chromatography. The impact of Paeonia lactiflora Pall seeds oil on the proliferation rate of B16F10 cells was assessed through the CCK‐8 method, while the melanin content of B16F10 cells was determined using the sodium hydroxide lysis method. The inhibitory effects of Paeonia lactiflora Pall seeds oil on elastase, collagenase and hyaluronidase were evaluated by biochemical techniques in vitro. Lastly, the hen's egg chorioallantoic membrane test (HET‐CAM) was conducted to confirm the absence of eye irritation caused by Paeonia lactiflora Pall seeds oil.ResultsPaeonia lactiflora Pall seeds oil within a certain volume concentration range (0.5%–4%) had no effect on the proliferation of B16F10 cells. Paeonia lactiflora Pall seeds oil showed significant inhibition of elastase, collagenase and hyaluronidase. Notably, the highest concentration tested, 4% Paeonia lactiflora Pall seed oil, yielded the most pronounced outcomes without causing any irritation.ConclusionA certain concentration of Paeonia lactiflora Pall seeds oil has a significant effect on decreasing the melanin content in B16F10 cells and inhibiting the activities of elastase, collagenase, and hyaluronidase, which can provide a reference for the development of pure natural cosmetics raw materials.
The effects of a real‐time temperature monitoring non‐ablative monopolar radiofrequency technology on vulvovaginal atrophy symptoms in postmenopausal Chinese women
Authors: Cheng Vivian , Chi‐Shing William Tai , Lee Athena , Lee Rita 
Published: March 2024

AbstractBackgroundVulvovaginal atrophy (VVA) includes a wide range of conditions affecting the reproductive and urinary systems, often requiring careful evaluation and management for optimal health.AimsThis study aims to evaluate the symptom management effects of a real time temperature‐monitored non‐ablative RF device for the treatment of postmenopausal Chinese women with VVA symptoms.MethodsThis pilot study involved 24 postmenopausal Chinese women with one or more VVA symptoms, who wished to remain sexually active. VHIS, VAS, and FSFI were used to track and evaluate various aspects of the patient's condition. Analyses were conducted at the end of the study to verify the statistical significance of the treatment's results.ResultsAll patients reported substantial, statistically significant, improvements on every VVA symptom tracked. Approximately 80% of the patients reported total symptom reversal at 12‐week post‐treatment follow‐up.ConclusionThis pilot study demonstrated that non‐ablative, monopolar RF technology equipped with real time temperature monitoring is feasible and safe in the treatment of postmenopausal women with VVA symptoms, and efficacious at up to 12 weeks post‐treatment.
A pilot study on the efficacy of a seaweed mud application in the treatment of cellulite
Authors: Amuso Domenico , Medoro Alessandro , Scapagnini Giovanni , Gambacorta Angela , Davinelli Sergio , Iorio Eugenio Luigi , Bonetti Luca Reggiani , Sbarbati Andrea 
Published: March 2024

AbstractBackgroundCellulite represents a common multi‐factorial condition that affects nearly all women and is now recognized as a clinical condition associated with systemic factors and negative psychological effects. Several noninvasive and minimally invasive treatments were developed during the last few years, but limited evidence supports many of them due to lack of evidence, insufficient participants, and potential adverse effects.MethodsThis study aimed to evaluate the efficacy of a seaweed mud application in improving both the structure and function of tissues affected by cellulite. Sixty women with cellulite underwent 4‐week applications of seaweed mud on the buttocks and thighs. The following assessments were performed at baseline and after the last treatment: photographic, clinical, and anthropometric evaluation; tests for elasticity and hydration; ultrasonography of cellulite nodules; and cellulite biopsies in the trochanteric region. Patient satisfaction was assessed using a 5‐point Likert‐scale questionnaire.ResultsThe treatment resulted in a significant improvement in the severity of cellulite severity between the initial assessment and the 4‐week follow‐up, with enhanced structure, elasticity, and hydration of the affected tissues. Microscopic analysis of the cellulite biopsies revealed a significant restoration of dermal organization with induced collagen synthesis and reduced inflammation, edema, and lipid deposition following the 4‐week seaweed mud applications. Additionally, the treatment led to a remarkable improvement in comfort and satisfaction as well as a reduction in body circumferences.ConclusionsThe cosmetic application of seaweed mud has proven to be a safe, non‐invasive treatment for improving the tissue alterations characteristic of cellulite.
Why moral psychology needs personality psychology
Authors: Sun Jessie , Smillie Luke D. 
Published: March 2024

AbstractPeople vary in how they perceive, think about, and respond to moral issues. Clearly, we cannot fully understand the psychology of morality without accounting for individual differences in moral functioning. But decades of neglect of and explicit skepticism toward such individual differences has resulted in a lack of integration between moral psychology and personality psychology—the study of psychological differences between people. In recent years, these barriers to progress have started to break down. This special issue aims to celebrate and further increase the visibility of the personality psychology of morality. Here, we introduce the articles in this special issue by highlighting some important contributions a personality‐based perspective has to offer moral psychology—particularly in comparison to the currently prominent social psychological approach. We show that personality psychology is well‐placed to (a) contribute toward a rigorous empirical foundation for moral psychology, (b) tackle the conceptualization and assessment of stable moral tendencies, (c) assess the predictive validity of moral traits in relation to consequential outcomes, (d) uncover the mechanisms underlying individual differences in moral judgments and behavior, and (e) provide insights into moral development. For these reasons, we believe that moral psychology needs personality psychology to reach its full scholarly potential.
Use of fermented malted barley by‐product as partial feed replacement and carbon source for rearing Nile tilapia (Oreochromis niloticus) juveniles
Authors: Cabanillas‐Gámez Miguel , Gómez‐Cadena Juan , Galaviz Mario A. , de Oca Gustavo Alejandro Rodríguez‐Montes , Figueroa‐Saavedra Fernando , López Lus M. , Trejo‐Escamilla Idaly , Barreto‐Curiel Fernando , López‐Valencia Gilberto 
Published: March 2024

AbstractThe present research evaluates the performance of the Nile tilapia (Oreochromis niloticus) (initial weight 11.5 ± 0.07 g) with biofloc technology. For this purpose, spent grains (malted barley) from the brewing industry after aerobic fermentation were used, as both a carbon source (suspended solids) and partial substitute for the diets at 0, 10, 20, 30, and 40% levels (settleable solids). The partial 20% substitution of the diet did not have significant effects on the biological parameters: final body weight, weight gained, average body weight, specific growth rate, daily growth index, condition factor, feed conversion ratio, protein efficiency rate, and viscerosomatic and hepatosomatic indices. However, the dietary substitution showed a significant effect on the final biofloc chemical composition. Nitrogen compounds, NH4+, NO2−, and NO3−, were adequate for tilapia cultivation in all the treatments. No clear effect of partial dietary substitution was observed on meat quality parameters: pH, color, water holding capacity, and amino acid and fatty acid profile of fillet. The results suggest that a 20% substitution of the diet for malted barley is suitable for satisfactory biological parameters and Nile tilapia fillet quality.
Recipient age influences survival after liver transplant: Results of the French national cohort 2007–2017
Authors: Lerosey Lea , Ksiasek Elea , Abrahamowicz Michal , Antoine Corinne , Dharancy Sébastien , Dumortier Jérôme , Doussot Alexandre , Di Martino Vincent , Houssel‐Debry Pauline , Conti Filomena , Francoz Claire , Pageaux Georges‐Philippe , Salame Ephrem , Faitot François , Coilly Audrey , Hardwigsen Jean , Decaens Thomas , Chermak Faiza , Muscari Fabrice , Anty Rodolphe , Duvoux Christophe , Abergel Armand , Minello Anne , Mouillot Thomas , Binquet Christine , Latournerie Marianne 
Published: March 2024

AbstractBackgroundIn recent years, age at liver transplantation (LT) has markedly increased. In the context of organ shortage, we investigated the impact of recipient age on post‐transplantation mortality.MethodsAll adult patients who received a first LT between 2007 and 2017 were included in this cross‐sectional study. Recipients' characteristics at the time of listing, donor and surgery data, post‐operative complications and follow‐up of vital status were retrieved from the national transplantation database. The impact of age on 5‐year overall mortality post‐LT was estimated using a flexible multivariable parametric model which was also used to estimate the association between age and 10‐year net survival, accounting for expected age‐ and sex‐related mortality.ResultsAmong the 7610 patients, 21.4% were aged 60–65 years, and 15.7% over 65. With increasing age, comorbidities increased but severity of liver disease decreased. Older recipient age was associated with decreased observed survival at 5 years after LT (p < .001), with a significant effect particularly during the first 2 years. The linear increase in the risk of death associated with age does not allow any definition of an age's threshold for LT (p = .832). Other covariates associated with an increased risk of 5‐year death were dialysis and mechanical ventilation at transplant, transfusion during LT, hepatocellular carcinoma and donor age. Ten‐year flexible net survival analysis confirmed these results.ConclusionAlthough there was a selection process for older recipients, increasing age at LT was associated with an increased risk of death, particularly in the first years after LT.
CaIAA2‐CaARF9 module mediates the trade‐off between pepper growth and immunity
Authors: Cai Weiwei , Tao Yilin , Cheng Xingge , Wan Meiyun , Gan Jianghuang , Yang Sheng , Okita Thomas W. , He Shuilin , Tian Li 
Published: March 2024

SummaryTo challenge the invasion of various pathogens, plants re‐direct their resources from plant growth to an innate immune defence system. However, the underlying mechanism that coordinates the induction of the host immune response and the suppression of plant growth remains unclear. Here we demonstrate that an auxin response factor, CaARF9, has dual roles in enhancing the immune resistance to Ralstonia solanacearum infection and in retarding plant growth by repressing the expression of its target genes as exemplified by Casmc4, CaLBD37, CaAPK1b and CaRROP1. The expression of these target genes not only stimulates plant growth but also negatively impacts pepper resistance to R. solanacearum. Under normal conditions, the expression of Casmc4, CaLBD37, CaAPK1b and CaRROP1 is active when promoter‐bound CaARF9 is complexed with CaIAA2. Under R. solanacearum infection, however, degradation of CaIAA2 is triggered by SA and JA‐mediated signalling defence by the ubiquitin‐proteasome system, which enables CaARF9 in the absence of CaIAA2 to repress the expression of Casmc4, CaLBD37, CaAPK1b and CaRROP1 and, in turn, impeding plant growth while facilitating plant defence to R. solanacearum infection. Our findings uncover an exquisite mechanism underlying the trade‐off between plant growth and immunity mediated by the transcriptional repressor CaARF9 and its deactivation when complexed with CaIAA2.
Unveiling the mechanism of source‐sink rebalancing in cucumber‐pumpkin heterografts: the buffering roles of rootstock cotyledon
Authors: Pu Dan , Wen Zheng‐Yang , Sun Jing‐Bo , Zhang Meng‐Xia , Zhang Feng , Dong Chun‐Juan 
Published: March 2024

AbstractGrafting onto pumpkin rootstock is widely applied in cucumber production to improve growth and yield, as well as to overcome soil‐borne diseases and enhance resistance to abiotic stresses. In this study, we constructed the cucumber‐pumpkin heterografts with the one‐cotyledon grafting method, and examined the effects of heterografting on biomass allocation and sugar partitioning, with cucumber and pumpkin self‐grafts used as control. Compared with cucumber self‐grafts, heterografting onto pumpkin rootstock promoted photosynthesis in cucumber scion, and led to higher sucrose contents in the 1st true leaf (source) and newly emerged leaf (sink). Thereby, the scion part of heterografts accumulated more biomass than cucumber self‐grafts. In contrast, when compared to pumpkin self‐grafts, grafting with cucumber scion reduced root vigor and biomass but promoted cotyledon growth in pumpkin rootstock. The roots (sink) of heterografts contained less sucrose and hexoses, and showed reduced sucrose synthase (SuSy) and hexokinase (HXK) activities. However, the rootstock cotyledon (source) contained more sucrose and starch, and showed higher activities of HXK, cell‐wall invertase (CWIN), and enzymes for starch synthesis and degradation. Furthermore, removal or shade of rootstock cotyledon led to reduced growth of root and scion. Silencing of CmoMEX1a gene in rootstock cotyledon inhibited maltose export and reduced root growth of heterografts. These results indicated that rootstock cotyledon, especially its starch content, played a buffering role in the growth regulation of cucumber‐pumpkin heterografts. Taken together, our results provided a major contribution to our understanding of source‐sink sugar partitioning and scion‐rootstock growth balancing in cucumber‐pumpkin heterografts.
Measured leaf dark respiratory CO2‐release is not controlled by stomatal conductance
Authors: Bruhn Dan , Faber Andreas H. , Cristophersen Kaare Sloth , Nielsen Jakob Svanekær , Griffin Kevin L. 
Published: March 2024

AbstractLeaf dark respiratory CO2‐release (RD) is, according to some literature, dependent on the rate of leaf transpiration. If this is true, then at a given vapor pressure deficit, the leaf stomatal conductance (gs) will be expected to be a controlling factor of measured RD at any given time. We artificially lowered leaf gs by applying abscisic acid (ABA). Although leaf RD generally covaried temporally with gs, artificially lowering gs by applying ABA does not affect the measured leaf RD. These results indicate that observed diel fluctuations in gs are not directly influencing the measured leaf RD, thereby simplifying both future studies and the interpretation of past studies of the underlying environmental‐ and physiological drivers of temporal variation in leaf RD.