bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Note on Proverbs 22:16
Authors: Ansberry Christopher 
Published: April 2024

Abstract
Proverbs 22:16 is plagued by syntactical ambiguity. In the light of the history of the aphorism’s reception, this note proposes a syntactical solution to the proverb’s syntactical openness: it is an unmarked יֵשׁ of reflection, which introduces paradoxical phenomena.
The Polemical Cosmogony in the Doxologies of Amos (4:13; 5:8; 9:5–6)
Authors: Ayali-Darshan Noga 
Published: April 2024

Abstract
The paper explores the doxologies in the book of Amos, arguing that they articulate a polemical viewpoint distinct from prevailing biblical and ancient Near Eastern notions about the formation of the sea, mountains, wind, and God’s abode. Central to the comprehension of this cosmogony is the recurring phrase in Amos 5:8d and 6:9c, “(He) who summons the waters of the sea and pours them on the surface of the earth.” While previous scholars have understood this phrase as referring to the primeval Flood, a tsunami event, or Levantine torrential rain, the present paper suggests a cosmogonic interpretation, in line with its context. Subsequent elements in the same series of texts are interlinked with this portrayal, emphasizing the unified—and polemical—perspective of the doxologies. This new explanation also has ramifications for the dating and composition of the doxologies in the book of Amos.
Creating a Multiply Imputed Value Set for the EQ-5D-5L in Canada: State-Level Misspecification Terms Are Needed to Characterize Parameter Uncertainty Correctly
Authors: Tsui Teresa C. O. , Chan Kelvin K. W. , Xie Feng , Pullenayegum Eleanor M. 
Published: April 2024

Background Parameter uncertainty in EQ-5D-5L value sets often exceeds the instrument’s minimum important difference, yet this is routinely ignored. Multiple imputation (MI) accounts for parameter uncertainty in the value set; however, no valuation study has implemented this methodology. Our objective was to create a Canadian MI value set for the EQ-5D-5L, thus enabling users to account for parameter uncertainty in the value set. Methods Using the Canadian EQ-5D-5L valuation study ( N = 1,073), we first refit the original model followed by models with state-level misspecification. Models were compared based on the adequacy of 95% credible interval (CrI) coverage for out-of-sample predictions. Using the best-fitting model, we took 100 draws from the posterior distribution to create 100 imputed value sets. We examined how much the standard error of the estimated mean health utilities increased after accounting for parameter uncertainty in the value set by using the MI and original value sets to score 2 data sets: 1) a sample of 1,208 individuals from the Canadian general public and 2) a sample of 401 women with breast cancer. Results The selected model with state-level misspecification outperformed the original model (95% CrI coverage: 94.2% v. 11.6%). We observed wider standard errors for the estimated mean utilities on using the MI value set for both the Canadian general public (MI: 0.0091; original: 0.0035) and patients with breast cancer (MI: 0.0169; original: 0.0066). Discussion and Conclusions We provide 1) the first MI value sets for the EQ-5D-5L and 2) code to construct MI value sets while accounting for state-level model misspecification. Our study suggests that ignoring parameter uncertainty in value sets leads to falsely narrow SEs. Highlights Value sets for health state utility instruments are estimated subject to parameter uncertainty; this parameter uncertainty may exceed the minimum important difference of the instrument, yet it is not fully captured using current methods. This study creates the first multiply imputed value set for a multiattribute utility instrument, the EQ-5D-5L, to fully capture this parameter uncertainty. We apply the multiply imputed value set to 2 data sets from 1) the Canadian general public and 2) women with invasive breast cancer. Scoring the EQ-5D-5L using a multiply imputed value set led to wider standard error estimates, suggesting that the current practice of ignoring parameter uncertainty in the value set leads to falsely low standard errors. Our work will be of interest to methodologists and developers of the EQ-5D-5L and users of the EQ-5D-5L, such as health economists, researchers, and policy makers.
Exploring Structural Uncertainty in Cost-Effectiveness Modeling of Gestational Diabetes Screening: An Application Example from Norway
Authors: Henkel Pia S. , Burger Emily A. , Sletner Line , Pedersen Kine 
Published: April 2024

Background Screening pregnant women for gestational diabetes mellitus (GDM) has recently been expanded in Norway, although screening eligibility criteria continue to be debated. We aimed to compare the cost-effectiveness of alternative GDM screening strategies and explored structural uncertainty and the value of future research in determining the most cost-effective eligibility criteria for GDM screening in Norway. Design We developed a probabilistic decision tree to estimate the total costs and health benefits (i.e., quality-adjusted life-years; QALYs) associated with 4 GDM screening strategies (universal, current guidelines, high-risk, and no screening). We identified the most cost-effective strategy as the strategy with the highest incremental cost-effectiveness ratio below a Norwegian benchmark for cost-effectiveness ($28,400/QALY). We excluded inconclusive evidence on the effects of screening on later maternal type 2 diabetes mellitus (T2DM) in the primary analysis but included this outcome in a secondary analysis using 2 different sources of evidence (i.e., Cochrane or US Preventive Services Task Force). To quantify decision uncertainty, we conducted scenario analysis and value-of-information analyses. Results Current screening recommendations were considered inefficient in all analyses, while universal screening was most cost-effective in our primary analysis ($26,014/QALY gained) and remained most cost-effective when we assumed a preventive effect of GDM treatment on T2DM. When we assumed no preventive effect, high-risk screening was preferred ($19,115/QALY gained). When we assumed GDM screening does not prevent perinatal death in scenario analysis, all strategies except no screening exceeded the cost-effectiveness benchmark. In most analyses, decision uncertainty was high. Conclusions The most cost-effective screening strategy, ranging from no screening to universal screening, depended on the source and inclusion of GDM treatment effects on perinatal death and T2DM. Further research on these long-term outcomes could reduce decision uncertainty. Highlights This article analyses the cost-effectiveness of 4 alternative gestational diabetes mellitus (GDM) screening strategies in Norway: universal screening, current (broad) screening, high-risk screening, and no screening. The current Norwegian screening recommendations were considered inefficient under all analyses. The most cost-effective screening strategy ranged from no screening to universal screening depending on the source and inclusion of GDM treatment effects on later maternal diabetes and perinatal death. The parameters related to later maternal diabetes and perinatal death accounted for most of the decision uncertainty.
The role of relationship beliefs in predicting levels and changes of relationship satisfaction
Authors: Gander Fabian , Uhlich Maximiliane , Traut Alex Christoph , Saameli Marcelle Ariane , Bühler Janina Larissa , Weidmann Rebekka , Grob Alexander 
Published: April 2024

Relationship beliefs (i.e., destiny and growth beliefs) are associated with important relationship outcomes. Destiny beliefs describe the belief that a relationship is meant to be while growth beliefs describe the tendency that relationships can be cultivated and maintained through effort. Based on a longitudinal sample of people in romantic relationships ( N = 904 couples), we examined whether destiny and growth beliefs predict current levels and trajectories of relationship satisfaction across 2 years. Using dyadic growth curve models, we found that individuals with stronger destiny beliefs generally reported higher initial relationship satisfaction. Furthermore, those with higher growth beliefs experienced a slower decline in relationship satisfaction over time. Vice versa, higher relationship satisfaction also predicted increases in growth beliefs, but not destiny beliefs over time. These findings were also supported when directly asking participants about their subjectively perceived trajectories of relationship satisfaction: Growth beliefs, but not destiny beliefs, went along with the perception that relationship satisfaction has increased in the past and will further increase in the future. The findings suggest that relationship beliefs are relevant for long-term outcomes and could have important implications for developing interventions to help couples maintain relationship satisfaction in the long term.
What Drives Mobile Payment Fin Tech Adoption in India?
Authors: Srivastava Shanu , Mohta Anu , Shunmugasundaram V 
Published: April 2024

This study aimed to determine the drivers of mobile payment FinTech adoption. The study was conducted with 306 generation Y (Gen Y) and generation Z (Gen Z) FinTech users, and data were analyzed using structural equation modelling (SEM) through partial least squares and analysis of variance (ANOVA). The present study investigates some interesting and novel associations among variables that contribute to the literature, such as the mediating effect of effort expectancy, facilitating condition, performance expectancy and social influence between the association of financial literacy and behavioural intention, and investigates the unified theory of acceptance and use of technology (UTAUT) constructs (effort expectancy, facilitating condition, performance expectancy and social influence), technology acceptance model 3 (TAM 3) constructs (perceived enjoyment and self-efficacy), financial literacy and demographic features as drivers of FinTech adoption. The results indicate that effort expectancy, performance expectancy, facilitating conditions, financial literacy and self-efficacy are strong drivers of FinTech adoption. Perceived enjoyment and social influence do not influence users’ behavioural intention to adopt mobile payment services. JEL Codes: G41, O30, O31, 033
Single-parent Adolescents’ Resilience and Psychological Well-being: The Role of Social Competence and Emotion Regulation
Authors: Sia Surendra Kumar , Aneesh Athira 
Published: April 2024

Background: Previous studies have shown that children and adolescents living with single parents are prone to behavioral and psychological difficulties and experience a poor sense of well-being. Also, the period of adolescence is critical for the development of an individual in multiple aspects; it is important to focus on their well-being and associated factors for a better transition into adulthood. Aim: This study aims to find the mediating role of social competence and emotion regulation on the relationship between resilience and psychological well-being among single-parent adolescents. Methods: This was a cross-sectional study. The study sample was 385 adolescents residing in Kerala (179 boys and 206 girls, mean age = 15.03, SD = 1.45). A total of 185 participants (48.1%) were from families that lost either of their parents to death, and the other 200 participants (51.9%) were from divorced or separated families. Self-reported measures for resilience, social competence, emotion regulation, and psychological well-being were used for data collection. Data were analysed using IBM SPSS and AMOS version 24. Results: The results showed that resilience, the prosocial behavior dimension of social competence, and the cognitive reappraisal dimension of emotion regulation indicate significant positive associations with the psychological well-being of adolescents living in single-parent families. The expressive suppression dimension of emotion regulation and the antisocial behavior dimension of social competence have a substantial negative connection with the psychological well-being of adolescents raised by single parents. The findings suggest that resilience directly predicts psychological well-being; prosocial behavior and cognitive reappraisal partially mediate the association of resilience and psychological well-being. Conclusion: According to our findings in this study, developing social competence skills and adaptive emotion regulation strategies can improve the psychological well-being of adolescents living with single parents. The results have multiple clinical, educational, and community implications.
Health Status of Working Women in a Tertiary Care Center, North Kerala, India: During the COVID-19 Pandemic
Authors: Joseph Robinson , Premlal K. S. , Anuja R. 
Published: April 2024

Introduction: Women constitute about one-half of the workforces in most countries and spend a significant proportion of their time at the workplace, contributing to a lot of physical and mental stress. The health-care professional in the workforce was the most affected during the COVID-19 pandemic. COVID-19 and noncommunicable diseases (NCDs) and associated risk factors have a substantial correlation. According to numerous studies from around the world, people who already have established risk factors such as diabetes, hypertension, obesity, or other vascular risk factors, are more likely to contract COVID-19 and experience complications or even pass away from it. Objectives: The objective is to assess the health status of working women in a tertiary health-care center in Kerala during the COVID-19 pandemic. Methodology: The study was done in a tertiary health-care center in Kozhikode district, Kerala, South India. This center comprises medical, paramedical and nursing institutes. A total of 262 women were included in the study, and data were collected using a semi-structured questionnaire. Results: This study demonstrated that working women’s stress was prevalent. It reveals that 94 (99.4%) women experience stress, 60.7% experience depression, 72.5% do not engage in daily physical activity and 80.8% of women were at risk of having NCDs. Conclusion: This study was an attempt to explore the health status of the women’s working health status during COVID-19 time. It found that some women are hypertensive, depressed and have stress-related disorders such as anxiety and worries. Mental health is directly linked with physical activity. The stress levels were controlled for those who were involved in physical activity on regular basis. Hence, we should work on this area to help improve these conditions.
A pilot study exploring the use of hyaluronic acid in treating insertional achilles tendinopathy
Authors: Ohana Nissim , Segal David , Kots Eugene , Feldman Viktor , Nyska Meir , Palmanovich Ezequiel , Slevin Omer 
Published: April 2024

Purpose This study explores the use of ultrasound-guided Hyaluronic Acid (HA) injections for Insertional Achilles Tendinopathy (IAT). Methods A cohort of 15 ankles diagnosed with IAT received three weekly ultrasound-guided HA injections. The Victorian Institute of Sport Assessment – Achilles (VISA-A) questionnaire scored the severity of symptoms and functional impairment before treatment, and at one and six months post-treatment. Results Significant improvement was observed in VISA-A scores post-treatment, rising from an average baseline of 34.8 ± 15.2 (11-63) to 53.6 ± 20.9 (15-77) after one month, and then to 50.7 ± 18.6 (20-75) after six months. No adverse reactions were noted, underscoring the safety of the intervention. Conclusion The pilot study presents HA injections as a potentially effective treatment for IAT, while interpretation of these findings must take into account the variability in results, indicating a range of patient responses. It encourages further research to confirm these findings and to explore HA’s full potential in managing IAT, despite the limitations of a small sample size and lack of control group.
Anatomic Variations of the Calcaneofibular Ligament
Authors: Ruzik Kacper , Gonera Bartosz , Borowski Andrzej , Karauda Piotr , Aragonés Paloma , Olewnik Łukasz 
Published: April 2024

Background: The lateral ankle joint comprises the anterior talofibular ligament (ATFL), calcaneofibular ligament (CFL), and posterior talofibular ligament (PTFL). The purpose of this study was to propose a classification of CFL morphology. Methods: The material comprised 120 paired lower limbs from human cadavers (30 male, 30 female), mean age 62.3 years. The morphology was carefully assessed, and morphometric measurements were performed. Results: A 4-part method for anatomic classification can be suggested based on our study. Type 1 (48.3%), the most common type, was characterized by a bandlike morphology. Type 2 (9.2%) was characterized by a Y-shaped band, and type 3 (21.7%) by a V-shaped band. Type 4 (20.8%) was characterized by the presence of 2 or 3 bands. Type 2 and 4 were divided into further subtypes based on origin footprint. Conclusion: The aim of our study was to describe variations of calcaneofibular ligament. Our proposed 4-part classification may be of value in clinical practice in future recognition of CFL injuries and in its repair or reconstruction. Clinical Relevance: The anatomy of the CFL plays an important role in stability of the ankle. Greater recognition of anatomical variation may help improve reconstructive options for patients with chronic lateral ankle instability.
Estrogen Receptor Is Required for Metformin-Induced Apoptosis in Breast Cancer Cells Under Hyperglycemic Conditions
Authors: Sekar Andisyah Putri , Nurmala Septia , Matsuura Eiji , Tan Xian Wen , Rahmasari Ratika , Sauriasari Rani 
Published: April 2024

Backgrounds: About 25% to 30% of estrogen receptor (ER)-positive breast cancer patients develop resistance to endocrine therapy. Human epidermal growth factor receptor 2 (HER2) has been shown to cooperate with several growth factors that regulate cellular energy metabolism, including the insulin-like growth factor 1 receptor (IGF-1R). Objective: As the first-line therapy for type 2 diabetes mellitus (T2DM) patients, metformin is widely known to inhibit the metabolic reprogramming of cancer cells. This study aims to investigate metformin’s efficacy in inhibiting endocrine resistance related to genes regulating energy metabolism in both ER-positive and ER-negative breast cancer cell lines under hyperglycemic conditions. Design and methods: MDA-MB-361 (ER-positive, HER2-positive) and SKBR3 (ER-negative, HER2-positive) cancer cell lines were used to represent ER status. Cell viability and cell survival rate were measured using the colorimetric assay of Cell Counting Kit-8. All mRNA levels were quantified using real-time quantitative polymerase chain reaction preceded by reverse transcription. A P value of <.05 was considered statistically significant. Results: Unlike MDA-MB-361, SKBR3 were found to acquire resistance upon metformin treatment in hyperglycemic conditions. Moreover, the mRNA expression of IGF-1R and its downstream signaling, such as the mammalian target of rapamycin (mTOR), was not affected by metformin. Meanwhile, the mRNA expression level of ribosomal S6 kinase 1 (S6K1) was upregulated, whereas forkhead box O1 (FOXO1) was downregulated after metformin treatment in hyperglycemic conditions. Conclusions: This preliminary study suggests that an alternative pathway of metformin resistance may exist in the absence of ERα. Therefore, relying solely on metformin may be inadequate to inhibit the aggressiveness of breast cancer cells.
Estimating droplet size and count distributions over a prolonged period of time following a cough in indoor environments
Authors: Jadidi Mehdi , Karataş Ahmet E , Dworkin Seth B 
Published: April 2024

An empirical correlation and a set of machine learning (ML) models were developed to estimate droplet size and count distributions over an extended duration after a cough at different relative humidities (RHs), air temperatures and locations within an indoor environment. Experiments covered RHs of 20%–80% and air temperatures of 21 °C–26 °C. Droplet count distributions for 4 size bins (0.3–0.5, 0.5–1, 1–3 and 3–5 μm) were recorded for 70 min within the distance of 2 m from the cough source. Different ML models, including decision tree, random forest and artificial neural network, were trained for each size bin to predict the associated count distribution. Amongst these models, random forest showed a slight superiority in performance. The coefficient of determination for the random forest models ranged from 0.912 to 0.989, indicating robust correlations between the features and the response variables. An empirical correlation was established linking the count distribution of 0.3–0.5 μm droplets to time, RH and distance along the cough direction. Both ML models and the correlation accurately predicted the trends and the distributions, providing valuable data for validating computational simulations and informing indoor environment control systems to reduce the risk of virus transmission.
Endovascular Repair Blunt Thoracic Aortic Injury in Adolescent: A Case Series
Authors: Deng Zhihe , Zhong Yaoyang , Zou Liping , Bi Guoshan , Chen Jie , Dai Xianpeng , Hu Jun , Xiong Guozuo , Deng Liming 
Published: April 2024

Background: Blunt traumatic aortic injury (BTAI) is a rare occurrence in adolescents, yet it is associated with a high mortality rate necessitating immediate treatment. Although endovascular repair has become the preferred treatment for such injuries in adults, its effectiveness in adolescents remains uncertain. Case summary: Blunt traumatic aortic injury typically presents with concomitant injuries to other organs and carries a high perioperative mortality rate with operative repair (OR). In this report, we describe the treatment of 3 clinical cases of BTAI in adolescents using thoracic endovascular aortic repair (TEVAR). These cases contribute pertinent evidence supporting the efficacy of intravascular repair for BTAI. Conclusion: Operative repair (OR) remains the gold standard for treating BTAI in adolescents. Nevertheless, TEVAR therapy presents a viable alternative for patients with multiple injuries in whom anticoagulation is contraindicated. Further long-term observation is necessary to assess the lasting effects of TEVAR therapy. Clinical Impact This study has provided insights into endovascular repair for adolescent BTAT, offering clinicians significant reference material for choosing treatment strategies for adolescent BTAT. The study aims to demonstrate the safety and effectiveness of endovascular repair treatments in a series of clinical cases involving adolescent BTAI.