bluuebunny/crossref_metadata_2025_split huggingface dataset:
Informatics and Medicine
Authors: Knoll A. , Mewes H.-W. , Schwaiger M. , Bode A. , Broy M. , Daniel H. , Feussner H. , Gradinger R. , Hauner H. , Höfler H. , Holzmann B. , Horsch A. , Kemper A. , Krcmar H. , Kochs E. F. , Lange R. , Leidl R. , Mansmann U. , Mayr E. W. , Meitinger T. , Molls M. , Navab N. , Nüsslin F. , Peschel C. , Reiser M. , Ring J. , Rummeny E. J. , Schlichter J. , Schmid R. , Wichmann H. E. , Ziegler S. , Kuhn K. A. 
Published: August 2008

Summary
Objectives: To clarify challenges and research topics for informatics in health and to describe new approaches for interdisciplinary collaboration and education. Methods: Research challenges and possible solutions were elaborated by scientists of two universities using an interdisciplinary approach, in a series of meetings over several months. Results and Conclusion: In order to translate scientific results from bench to bedside and further into an evidence-based and efficient health system, intensive collaboration is needed between experts from medicine, biology, informatics, engineering, public health, as well as social and economic sciences. Research challenges can be attributed to four areas: bioinformatics and systems biology, biomedical engineering and informatics, health informatics and individual healthcare, and public health informatics. In order to bridge existing gaps between different disciplines and cultures, we suggest focusing on interdisciplinary education, taking an integrative approach and starting interdisciplinary practice at early stages of education.* See more detailed authors´ affiliations at the end of the article.
Medical Informatics Is Interdisciplinary avant la Lettre
Authors: van Bemmel J. H. 
Published: August 2008

Summary

Objective:
To discuss the elements of interdisciplinary research and to analyze its contribution to (bio)medical informatics.

Method:
Commenting on ‘Informatics and Medicine – From Molecules to Populations‘ from K. A. Kuhn et al. in this issue of Methods of Information in Medicine. Referring to examples of successfully established interdisciplinary research.

Results and Conclusions:
Medical informatics is an interdisciplinary field avant la lettre. Experience with successful interdisciplinary research already exists for many decades: Interdisciplinary research is not a category of research but a consequence of addressing a complex problem in society, involving the collaboration between and methods drawn from multiple disciplines. Because research is people, personal interactions are critical for interdisciplinary research. Collaboration takes extra time to develop, to build consensus and to understand new methodologies, languages, and each other‘s culture. Interdisciplinary research requires leaders with vision and expressive skills. Effective scientific and institutional leadership is critical to the success of interdisciplinary groups. Interdisciplinarity begins in the classroom. Interdisciplinary research cannot be effective without interdisciplinary education. Researchers and teachers should immerse themselves in the culture of other disciplines, learning to explain their work in terms understood by people outside their own discipline. Teams that perform interdisciplinary research should promote collaboration, meet regularly, and recognize that it requires a commitment toward good communication and clear goals. Although much progress is achieved by interdisciplinary research, basic monodisciplinary research is still required to advance the frontiers of scientific knowledge, such as in physics or biology.
Effect of SWNT Defects on the Electron Transfer Properties in P3HT/SWNT Hybrid Materials
Authors: Geng Jianxin , Kong Byung‐Seon , Yang Seung Bo , Youn Sang Cheon , Park Sohyun , Joo Taiha , Jung Hee‐Tae 
Published: August 2008

AbstractPoly(3‐hexylthiophene) (P3HT) hybrids with single‐walled carbon nanotubes (SWNTs) were prepared using a series of SWNTs with various defect contents on their surfaces. The hybrids were synthesized by exploiting the π–π interaction between P3HT and the SWNTs, resulting in efficient dispersion of the carbon nanotubes in the P3HT solution. UV‐visible and photoluminescence (PL) spectra showed that the carbon nanotubes quench the PL of P3HT in the hybrids, indicating that electron transfer occurs from photo‐excited P3HT to the SWNTs. This electron transfer from P3HT to carbon nanotubes was disrupted by the presence of defects on the SWNT surfaces. However, the PL lifetime of P3HT in the hybrids was found to be the same as that of pure P3HT in solution, indicating the formation of a ground‐state non‐fluorescent complex of P3HT/SWNTs.
Venous sinus thrombosis leading to stroke in a patient with sickle cell disease on hydroxyurea and high hemoglobin levels: Treatment with thrombolysis
Authors: Sidani Charif A. , Ballourah Walid , El Dassouki Mohamad , Muwakkit Samar , Dabbous Ibrahim , Dahoui Hanan , Al‐Kutoubi Aghiad , Abboud Miguel R. 
Published: August 2008

AbstractA 21‐year‐old man with homozygous sickle cell disease maintained on hydroxyurea for 1 year developed thrombosis of the superior sagittal, right transverse, and right sigmoid dural sinuses with a large venous infarct. He was successfully treated with endovascular thrombolysis. Investigation did not reveal any inherited or acquired hypercoagulable state. This patient however had consistently elevated hemoglobin levels both at the time of the initial event and on follow up. One year later he developed symptomatic avascular necrosis of the right hip. High hemoglobin levels resulting from hydroxyurea therapy may have contributed to development of complications in this patient. Am. J. Hematol., 2008. © 2008 Wiley‐Liss, Inc.
Chemoselective Oxidation of Alcohols by a H2O2–Pt Black System under Organic Solvent‐ and Halide‐Free Conditions
Authors: Kon Yoshihiro , Yazawa Hideaki , Usui Yoko , Sato Kazuhiko 
Published: August 2008

AbstractEnvironmentally benign oxidation of allylic alcohols by platinum black catalyst with aqueous hydrogen peroxide to give the corresponding α,β‐unsaturated carbonyl compounds in high yield is presented. Reactions are carried out under organic solvent‐ and halide‐free conditions. The platinum black catalyst is commercially available and is found to be reusable at least seven times before significant loss of catalytic activity. The operation is very simple, even in a hectogram‐scale synthesis, and gives corresponding carbonyl compounds in over 90 % yield. The effective oxidation of benzyl and secondary alcohols are also described.
Spot‐Monitoring zur Ermittlung der thermischen Behaglichkeit in Bürogebäuden unter Berücksichtigung der Lüftungs‐ und Klimatisierungsvarianten
Authors: Kuchen Ernesto , Kühl Lars , Fisch M. Norbert 
Published: August 2008

AbstractIm Rahmen der energetischen Optimierung von Neubau‐ und Bestands‐Bürogebäuden gewinnt die Einhaltung der thermischen Komfortbedingungen in den Arbeitsräumen eine steigende Bedeutung. Die in den Normen derzeit fehlende Berücksichtigung der Adaption des Nutzerempfindens stellt sich über die gewonnenen Erkenntnisse als wesentliche Einflussgröße der Bewertung der thermischen Behaglichkeit insbesondere in nichtklimatisierten Räumen dar. Das Spot‐Monitoring‐Konzept wird als Kurzzeit‐Messverfahren zur Analyse des thermischen Komforts entwickelt. Das Verfahren zur Ermittlung der neutralen Temperatur wird in Praxistests in 30 Bürogebäuden unterschiedlichen Klimatisierungsgrades evaluiert. Das Messverfahren besteht aus zu verschiedenen Jahreszeiten in jeweils unterschiedlich orientierten Büroräumen durchgeführten Kurzzeitmessungen. Während der Aufnahme der für die Ermittlung der Bewertung des Raumklimas wesentlichen Parameter (Operativtemperatur, Luftgeschwindigkeit, etc.) wird parallel eine Nutzerbefragung zur subjektiven Bewertung des Raumklimazustandes der jeweiligen Person durchgeführt. Die unter Berücksichtung des Nutzerempfindens ermittelte neutrale Temperatur verhält sich proportional zur Veränderung der operativen Temperatur und ist damit nicht konstant. Die Ergebnisse zeigen einen wesentlichen Einfluss der Nutzeranpassung auf die Bewertung der thermischen Behaglichkeit in Räumen.
Erweiterung des Hitzewarnsystems um die Vorhersage der Wärmebelastung in Innenräumen
Authors: Pfafferott Jens , Becker Paul 
Published: August 2008

AbstractAls eine Anpassungsmaßnahme an den Klimawandel und als direkte Konsequenz aus dem Hitzesommer 2003 wurde in Deutschland ein Hitzewarnsystem (Heat Health Warning System HHWS) aufgebaut. Eine prinzipielle Einschränkung des beim Deutschen Wetterdienst eingesetzten Systems bestand darin, dass nur Aussagen über die Verhältnisse im Freien gemacht werden konnten. Die häufig sehr stark abweichende Innenraumsituation wurde nicht berücksichtigt. Dazu wurde das bestehende Hitzewarnverfahren um ein thermisches Gebäudesimulationsmodell erweitert. Es erlaubt eine Abschätzung der Wärmebelastung in Innenräumen in Abhängigkeit von den vorhergesagten meteorologischen Außenbedingungen. Obwohl sich das Vorhersagemodell aus Praktikabilitätsgründen auf einen “ungünstigen Fall” beschränkt, liefern die Belastungswerte eine bedeutende Information. Das Verfahren wurde im Sommer 2007 im Parallelbetrieb eingesetzt und machte den Zusatznutzen deutlich.
Was bedeutet “Platin”? – Zur Entwicklung von Nachhaltigkeitsbewertungsverfahren
Authors: Gertis Karl , Hauser Gerd , Sedlbauer Klaus , Sobek Werner 
Published: August 2008

AbstractIn der derzeitigen politischen Diskussion über die Klimaveränderung wird der CO2‐Bilanz und dem Energieverbrauch bzw. den mit steigenden Energiepreisen verbundenen Energiekosten eine fast überlastige Bedeutung beigemessen. Umso erfreulicher ist es, dass sich die Bundesregierung mit einem Leitfaden auch der Nachhaltigkeit des Bauens annimmt, welche die Energieeinsparung einschließt, aber weit über diese hinausgeht, und dass sich hierzu im Jahre 2007 – wenn auch im internationalen Vergleich spät – die Deutsche Gesellschaft für nachhaltiges Bauen (DGNB) gebildet hat; verspätet deshalb, weil in Großbritannien mit BREEAM bereits 1990 ein relativ ausgereiftes Nachhaltigkeitsbewertungsverfahren bekannt geworden war, auf das in den USA mit LEED 1995 aufgebaut wurde. Die vorliegende Arbeit versucht, “Grundstöcke” für die Nachhaltigkeitsbeurteilung aufzuzeigen, ein Kriterien‐Ordnungssystem aufzubauen und daraus einige Konsequenzen abzuleiten.
Vergleichende Berechnungen des Energieverbrauchs einer Standardfassade und der zur Ausführung gekommenen Fassade für die neue Konzernzentrale der Energie AG in Linz
Authors: Köster Helmut 
Published: August 2008

AbstractDie Energie AG Oberösterreich hatte sich für den Neubau der Konzernzentrale in Linz (Bild 1) von Beginn des Planungsprozesses an zum Ziel gesetzt, ein energieoptimiertes Gebäude zu erstellen. Weltweit erstmals kommt für ein Bürohochhaus dieser Größe fast der gesamte Energiebedarf aus erneuerbaren Energieträgern. Das Energiekonzept für den “Power Tower” besteht aus den drei Teilen: Gebäudehülle, Haustechnik, Energieaufbringung. Die neue Konzernzentrale wird ohne Fernwärmeanschluss auskommen und auf den Einsatz von fossilen Energieträgern für Heizung und Kühlung verzichten können. Energie wird aus der 700m2 großen Photovoltaikanlage an der Süd‐West‐Fassade erzeugt. Neben verschiedenen energiesparenden Maßnahmen der Wärme‐ und Kältegewinnung kam es besonders darauf an, die Gebäudehülle bezüglich ihres thermischen Verhaltens zu optimieren. Über das neuartige, in die Außenwandkonstruktion integrierte Sonnenschutzsystem berichtet dieser Beitrag.
Electrostatic interactions between hyaluronan and proteins at pH 4: How do they modulate hyaluronidase activity
Authors: Lenormand Hélène , Deschrevel Brigitte , Tranchepain Frédéric , Vincent Jean‐Claude 
Published: August 2008

AbstractHyaluronan (HA) hydrolysis catalyzed by hyaluronidase (HAase) is inhibited at low HAase over HA ratio and low ionic strength, because HA forms electrostatic complexes with HAase, which is unable to catalyze hydrolysis. Bovine serum albumin (BSA) was used as a model to study the HA‐protein electrostatic complexes at pH 4. At low ionic strength, there is formation of (i) neutral insoluble complexes at the phase separation and (ii) small positively‐charged or large negatively‐charged soluble complexes whether BSA or HA is in excess. According to the ionic strength, different types of complex are formed. Assays for HA and BSA led to the determination of the stoichiometry of these complexes. HAase was also shown to form the various types of complex with HA at low ionic strength. Finally, we showed that at 0 and 150 mmol L−1 NaCl, BSA competes with HAase in forming complexes with HA and thus induces HAase release resulting in a large increase in the hydrolysis rate. These results, in addition to data in the literature, show that HA–protein complexes, which can exist under numerous and varied conditions of pH, ionic strength and protein over HA ratio, might control the in vivo HAase activity. © 2008 Wiley Periodicals, Inc. Biopolymers 89: 1088–1103, 2008.This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com
Signal Transducers and Activators of Transcription as Targets for Small Organic Molecules
Authors: Berg Thorsten 
Published: August 2008

AbstractSignal transducers and activators of transcription (STATs) are a family of transcription factors that are of central importance for cellular signaling and have therefore emerged as attractive target proteins for cell‐permeable small molecules. This review outlines the basic concept of STAT signaling, the relevance of individual members of the STAT family for cellular signaling and human disease, and generally applicable approaches taken to the identification of small‐molecule inhibitors of STATs.
Reaction Mechanism of Molybdoenzyme Formate Dehydrogenase
Authors: Leopoldini Monica , Chiodo Sandro G. , Toscano Marirosa , Russo Nino 
Published: August 2008

AbstractFormate dehydrogenase is a molybdoenzyme of the anaerobic formate hydrogen lyase complex of the Escherichia coli microrganism that catalyzes the oxidation of formate to carbon dioxide. The two proposed mechanisms of reaction, which differ in the occurrence of a direct coordination or not of a SeCys residue to the molybdenum metal during catalysis were analyzed at the density functional level in both vacuum and protein environments. Some DF functionals, in addition to the very popular B3LYP one, were employed to compute barrier heights. Results revealed the role played by the SeCys residue in performing the abstraction of the proton from the formate substrate. The computation of the energetic profiles for both mechanisms indicated that the reaction barriers are higher when the selenium is directly coordinated to the metal, whereas less energy is required when SeCys is not a ligand at the molybdenum site.
ChemInform Abstract: Two New Examples of very Short Thallium—Transition Metal Contacts: Tl3Ag3Sb2S6 and Tl3Ag3As2S6.
Authors: Karanovic Ljiljana , Poleti Dejan , Balic‐Zunic Tonci , Makovicky Emil , Grzetic Ivan 
Published: August 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A New Ternary Nitride La2GaN3: Synthesis and Crystal Structure.
Authors: Chevire Francois , DiSalvo Francis J. 
Published: August 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Structure of Ternary Imide Li2Ca(NH)2 and Hydrogen Storage Mechanisms in Amide—Hydride System.
Authors: Wu Hui 
Published: August 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Syntheses and Structures of the Germanides CaNiGe and MgCoGe as well as Chemical Bonding in CaNiGe and CaNi2Ge2.
Authors: Hlukhyy Viktor , Chumalo Nataliya , Zaremba Vasyl' , Faessler Thomas F. 
Published: August 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Study of the Al‐Rich Part of the Al—Re Alloy System.
Authors: Balanetskyy S. , Grushko B. 
Published: August 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Hydrogen Storage in a LiNH2—MgH2 (1:1) System.
Authors: Liu Yongfeng , Zhong Kai , Gao Mingxia , Wang Jianhui , Pan Hongge , Wang Qidong 
Published: August 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Polar Oxide ZnSnO3 with a LiNbO3‐Type Structure.
Authors: Inaguma Yoshiyuki , Yoshida Masashi , Katsumata Tetsuhiro 
Published: August 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Ordered Tetragonal Spinel LiMnNbO4 Prepared in Reducing Atmosphere.
Authors: Shukaev I. L. , Pospelov A. A. , Gannochenko A. A. 
Published: August 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Transformation of 1,5‐Diphenylpentane‐1,3,5‐trione (I). The Synthesis of Substituted (4H)‐Pyranones, Pyridin‐4(1H)‐ones and 4H‐Pyrano[3,2‐c]pyridin‐4‐ones.
Authors: Zupancic Silvo , Svete Jurij , Stanovnik Branko 
Published: August 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Unusual Intramolecular Cyclization of Adducts of Diphenylacetylene with Hetarenesulfenyl Chlorides.
Authors: Osmanov V. K. , Borisova G. N. , Geronikaki A. , Borisov A. V. 
Published: August 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Mild, Efficient Method for the Oxidation of α‐Diazo‐β‐hydroxyesters to α‐Diazo‐β‐ketoesters.
Authors: Li Puhui , Majireck Max M. , Korboukh Ilia , Weinreb Steven M. 
Published: August 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Olefin Cross‐Metathesis Reactions at Room Temperature Using the Nonionic Amphiphile “PTS”: Just Add Water.
Authors: Lipshutz Bruce H. , Aguinaldo Grant T. , Ghorai Subir , Voigtritter Karl 
Published: August 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Tetrafluoroboric Acid Adsorbed on Silica Gel as a Reusable Heterogeneous Dual‐Purpose Catalyst for Conversion of Aldehydes/Ketones into Acetals/Ketals and Back Again.
Authors: Kumar Dinesh , Kumar Raj , Chakraborti Asit K. 
Published: August 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Molybdenum Pentachloride (MoCl5) or Molybdenum Dichloride Dioxide (MoO2Cl2): Advanced Catalysts for Thioacetalization of Heterocyclic, Aromatic and Aliphatic Compounds.
Authors: Goswami Shyamaprosad , Maity Annada C. 
Published: August 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: One‐Pot Sequential Cross‐Metathesis/Hydride Reduction: Highly Stereoselective Synthesis of Primary (E)‐Allylic Alcohols from Terminal Olefins.
Authors: Paul Tapas , Sirasani Gopal , Andrade Rodrigo B. 
Published: August 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Novel Copper Hydride Promoted 1,3‐Rearrangement of α‐Allenylcyclopropane Systems to Methylenecyclopentenes.
Authors: Hiroi Kunio , Kato Fumiko , Oguchi Takamasa , Saito Shinya , Sone Takanori 
Published: August 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Azo Bond Hydrogenation with Hydrazine, R—NHNH2, and Hydrazobenzene.
Authors: Koppes William M. , Moran Jesse S. , Oxley Jimmie C. , Smith James L. 
Published: August 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.