bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of the possible impact of the fear of hypoglycemia on diabetes management in children and adolescents with type 1 diabetes mellitus and their parents: a cross-sectional study
Authors: Andreopoulou Ourania , Kostopoulou Eirini , Kotanidou Eleni , Daskalaki Sophia , Vakka Angeliki , Galli-Tsinopoulou Assimina , Spiliotis Bessie E 
Published: April 2024

Abstract
Purpose
Hypoglycemia represents a significant source of anxiety for children with type 1 diabetes mellitus (T1DM) and their caretakers. Fear of hypoglycemia (FoH) was measured in children and adolescents with T1DM as well as in their parents using an established research instrument, the Hypoglycemia Fear Survey (HFS).

Methods
This is a two-center, cross-sectional study involving 100 children and adolescents aged 6–18 years old diagnosed with T1DM. One parent of each child also participated in the study. The participants, who were recruited from two different pediatric endocrine outpatient clinics, were asked to complete the translated Greek version of the HFS, which includes one version for children (C-HFS) and one for parents (P-HFS). The association of the questionnaire responses with subjects’ characteristics, such as current age, age at diagnosis, duration of diabetes, HbA1c levels, and mode of diabetes treatment were assessed.

Results
Parents exhibited significantly higher mean HFS scores than their children. No significant correlation was found between the P-HFS or the C-HFS scores and the age of the children, duration of diabetes, HbA1c, or mode of treatment.

Conclusion
The finding that parents experience higher levels of FoH compared to their children emphasizes the importance of healthcare providers to screen parental FoH and focus on approaches to support them in order to reduce their psychological burden, thus optimizing children’s diabetes management.
Combined Vinasse and Mineral NPK Fertilizer Affect Physio-Biochemical, Root, and Yield Characters of Faba Bean (vicia faba l.) Genotypes Grown on Saline Soil
Authors: Ebaid Mohamed , El‑Hady M. A. Abd , El‑Temsah M. E. , El‑Gabry Y. A. , Abdelkader M. A. , Alwahed Saaied Helmy Abd Alhalim Abd , Salama Eslam , Morsi Nahid A. A. , Taha Noura M. , Saad Ahmed M. , Abd‑Elkrem Yasser M. 
Published: April 2024

Abstract The objective of this study is to assess the effects of combined applications of recommended traditional chemical fertilization NPK 100% without Vinasse and with 100, 75, 50 NPK + Vinasse on Physio-Biochemical, root, shoot traits, yield, and its attributes for four faba bean Giza-429, Giza-843, Misr-2 and Sakha-3 genotypes which are cultivated in the soil is salt affected of eastern Egypt. The experimental design was conducted using a strip-plot design with three replicates in 2020 and 2021. Treatments of different doses of chemical fertilization were 100% NPK without Vinasse and 100%, 75%, and 50% of NPK with Vinasse as supplementary organic fertilizer were arranged in vertical strips, while horizontal strips were devoted to faba bean genotypes (Vicia faba L.) i.e. Giza-429, Giza-843, Misr-2, and Sakha-3. Relative to the other fertilizer combinations, the 75% NPK + Vinasse did not contribute more than 5% more yield to Sakha 3 than it did with the 100% NPK + Vinasse. Both the fertilizer and cultivar main effects had the same positive linear trend, with relatively higher total seed yield in the case of the 75% NPK + Vinasse and of cv. Sakha 3. The harvest index (HI) was different only for fertilizer levels.The 75% NPK + Vinasse differed by a very negligible margin from the 100% NPK + Vinasse, but both differed from the other two levels. Along with seed yield, both straw and biological yields were significant for the interaction effects, as well as for the main effects. Within all fertilizer combinations, cultivars Giza 843 and Saka 3 consistently, as a subgroup, outyielded the other two cultivars, not only for total seed yield but also for all other yield component characters.
Biotinylated cyclic naphthalene diimide as a searching tool for G4 sites on the genome
Authors: Fujii Satoshi , Sato Shinobu , Hidaka Ryuki , Takenaka Shigeori 
Published: April 2024

AbstractA biotinyl cyclic naphthalene diimide (biotinyl cNDI) (1), in which biotin is introduced on the cyclic linker chain of cNDI with high G-quadruplex (G4) specificity, was synthesized. 1 was used for binding analysis to G4 DNAs such as c-myc, c-kit, CEGF, or TA-core. The results showed that 1 bind to G4 DNAs with high affinity and, especially, two molecules of 1 bind to c-myc DNA from top and bottom of G4 site at K = 3.9 × 10−6 M−1 without changing the G4 structure. As a pulldown assay, 1 and streptavidin magnetic beads could be used to recover a c-myc DNA or 120-mer DNA fragment having single c-myc sequence. The qPCR results for the 120-meric DNAs showed that more than 50% of genomic DNA fragments could be recovered by this pulldown assay. The results obtained here might allow the recovery of G4-containing DNA fragments from genomic DNA to analyze the true G4 present in the genome.
Graphic abstract
Outdoor thermal comfort in open transitional spaces with limited greenery in hot summer/cold winter climates
Authors: Azimi Zahra , Kashfi Seyed Sobhan , Semiari Amir , Shafaat Ali 
Published: April 2024

AbstractRegarding the constant use of transitional spaces, there is an intense interest in studies on the outdoor thermal comfort in transitional spaces, especially in regions with hot summers. This study aims to analyze the outdoor thermal comfort conditions of a transitional space focusing on vegetation cover change to distill findings into a set of design guidelines for landscape architects and urban planners to enhance the thermal comfort in open transitional spaces, especially in airport terminals with hot summer, and cold winter climate. The case study for this research is an open transitional area at the Mehr-Abad airport. Mehr-Abad airport experiences blistering summers and freezing winters. The environmental situation is analyzed using ENVI-met software. Subsequently, without-grass and without-tree scenarios were simulated to study the impact of greenery on transitional thermal comfort. The results were validated using the on-site collected data. In this study, results demonstrate that the average PET in the current situation is 39.81 ℃ in summer (hot sensation) and 5 ℃ in winter (cold sensation). Based on the results, removing the grass cover is the most suitable scenario for both summer with 35.80 ℃, and winter with 6.68 ℃. The best scenario consists of adding more deciduous trees to open transitional spaces to reduce solar shading in winter. This study provided a better understanding of the effects of vegetation in transient-oriented limited spaces on outdoor thermal comfort and looked deeper into vegetation characteristics concerning the transitional space requirements in hot summer/cold winter climates.
Design, Cultivation, and Acoustic Analysis of a Building-Sized Mycelium Sculpture
Authors: Dessi-Olive Jonathan , Hsu Timothy , Oliyan Omid 
Published: April 2024

Abstract
This paper describes novel computational design, simulation, and fabrication techniques employed in the production of a large sound-absorbing sculpture called Phoenix, made entirely from mycelium-composite materials (myco-materials). Myco-materials are composites made of lignocellulosic agricultural waste fibers bound by fungal mycelium and are produced at commercial scale as alternatives for plastics, insulation foam, or styrene. Mycelium composite materials have known acoustical properties that can be tuned according to variables such as growing time, substrate type, substrate size, and density. The fabrication method for producing the Phoenix sculpture revisits how we build performative and formal complexity in the most economic and sustainable way. The results indicate the potential for grown materials to be used in retrofit projects, allowing rooms to be customized in various acoustical situations, such as music or speech.
Stability-based approaches in chemoproteomics
Authors: George Amy L. , Dueñas Maria Emilia , Marín-Rubio José Luis , Trost Matthias 
Published: April 2024

Abstract
Target deconvolution can help understand how compounds exert therapeutic effects and can accelerate drug discovery by helping optimise safety and efficacy, revealing mechanisms of action, anticipate off-target effects and identifying opportunities for therapeutic expansion. Chemoproteomics, a combination of chemical biology with mass spectrometry has transformed target deconvolution. This review discusses modification-free chemoproteomic approaches that leverage the change in protein thermodynamics induced by small molecule ligand binding. Unlike modification-based methods relying on enriching specific protein targets, these approaches offer proteome-wide evaluations, driven by advancements in mass spectrometry sensitivity, increasing proteome coverage and quantitation methods. Advances in methods based on denaturation/precipitation by thermal or chemical denaturation, or by protease degradation are evaluated, emphasising the evolving landscape of chemoproteomics and its potential impact on future drug-development strategies.
Effect of different doses of camelina cake inclusion as a substitute of dietary soyabean meal on growth performance and gut health of weaned pigs
Authors: Luise Diana , Correa Federico , Cestonaro Giulia , Sattin Eleonora , Conte Giuseppe , Mele Marcello , Archetti Ivonne , Virdis Sara , Negrini Clara , Galasso Incoronata , Stefanelli Claudio , Mazzoni Maurizio , Nataloni Luigi , Trevisi Paolo , Costanzo Enrico 
Published: April 2024

AbstractCamelina cake (CAM) is a co-product proposed as an alternative protein source; however, piglet data are still limited. This study aimed to evaluate the effect of different doses of CAM in substitution of soyabean meal on the growth, health and gut health of weaned pigs. At 14 d post-weaning (d0), sixty-four piglets were assigned either to a standard diet or to a diet with 4 %, 8 % or 12 % of CAM. Piglets were weighed weekly. At d7 and d28, faeces were collected for microbiota and polyamine and blood for reactive oxygen metabolites (ROM) and thyroxine analysis. At d28, pigs were slaughtered, organs were weighed, pH was recorded on gut, colon was analysed for volatile fatty acids (VFA) and jejunum was used for morphological and gene expression analysis. Data analysis was carried out using a mixed model including diet, pen and litter as factors; linear and quadratic contrasts were tested. CAM linearly reduced the average daily gain from d0–d7, d0–d14, d0–d21 and d0–d28 (P ≤ 0·01). From d0–d7 increasing CAM linearly decreased feed intake (P = 0·04) and increased linearly the feed to gain (P = 0·004). CAM increased linearly the liver weight (P < 0·0001) and affected the cadaverine (P < 0·001). The diet did not affect the ROM, thyroxine, intestinal pH, VFA and morphology. All doses of CAM increased the α diversity indices at d28 (P < 0·05). CAM at 4 % promoted the abundance of Butyricicoccaceae_UCG-008. Feeding with CAM enhanced resilience in the gut microbiome and can be evaluated as a potential alternative protein source with dose-dependent limitations on piglet growth performance.
Post-prandial tracer studies of protein and amino acid utilisation: what can they tell us about human amino acid and protein requirements?
Authors: Millward D. Joe 
Published: April 2024

AbstractNitrogen balance (NB), the principal methodology used to derive recommendations for human protein and amino acid requirements, has been widely criticised, and calls for increased protein and amino acid requirement recommendations have been made, often on the basis of post-prandial amino acid tracer kinetic studies of muscle protein synthesis, or of amino acid oxidation. This narrative review considers our knowledge of the homeostatic regulation of the FFM throughout the diurnal cycle of feeding and fasting and what can and has been learnt from post-prandial amino acid tracer studies, about amino acid and protein requirements. Within the FFM, muscle mass in well fed weight-stable adults with healthy lifestyles appears fixed at a phenotypic level within a wide range of habitual protein intakes. However homoeostatic regulation occurs in response to variation in habitual protein intake, with adaptive changes in amino acid oxidation which influence the magnitude of diurnal losses and gains of body protein. Post-prandial indicator amino acid oxidation (IAAO) studies have been introduced as an alternative to NB and to the logistically complex 24 h [13C-1] amino acid balance studies, for assessment of protein and amino acid requirements. However, a detailed examination of IAAO studies shows both a lack of concern for homeostatic regulation of amino acid oxidation and major flaws in their design and analytical interpretation, which seriously constrain their ability to provide reliable values. New ideas and a much more critical approach to existing work is needed if real progress is to be made in the area.
Adaptive backstepping controller based on a novel framework for dynamic solution of an ankle rehabilitation spherical parallel robot
Authors: Ahmadi N Ali , Kamali Eigoli Ali , Taghvaeipour Afshin 
Published: April 2024

AbstractThis research offers an adaptive model-based methodology for autonomous control of 3-RRR spherical parallel manipulator (RSPM) based on a novel modeling framework. RSPM is an overconstrained parallel mechanism that has a variety of applications in medical procedures such as ankle rehabilitation because of its precision and accuracy. However, obtaining a complete explicit dynamic model of these mechanisms for tracking purposes has been a problematic challenge due to their inherent singularities, coupling effects of the limbs, and redundant constraints imposed by the intermediate joints. This paper presents a novel algorithm to obtain the analytical kinematic solutions of RSPMs based on the closed-loop vector method, which includes constraint analysis. By incorporating constrained kinematics into the dynamic model, a comprehensive explicit dynamic solution of the non-overconstrained version 3-RCC of RSPM is developed in task space, based on screw theory and the linear homogeneous property of algebraic equations on the manipulator twist. Based on the proposed computational framework, a robust self-tuning backstepping control (STBC) strategy is applied to the robot to overcome the effect of external disturbances and time-varying uncertainties. Furthermore, an observer-based compensation (OBC) method is presented for dealing with the nonlinear hysteresis loops of the ankle during trajectory tracking purposes. The closed-loop stability of the whole system including STBC and OBC is theoretically performed by Lyapunov methods. The proposed methodologies are validated by realistic co-simulations in different scenarios. For instant, in the presence of external disturbances, the maximum tracking error norm of STBC is 37.5% less than the sliding mode approach.
Effectiveness of pulmonary valve-sparing strategy for transatrial-transpulmonary repair of tetralogy of Fallot: a single institution experience
Authors: Minh Dien T. , Huu Uoc N. , Tuan Bao L. , Tuan Mai N. , Dinh Duyen M. , Quang Vinh T. , Hong Quang Le , St. Louis James , Ly Thinh Truong N. 
Published: April 2024

AbstractObjective:We report the midterm results of our strategy utilizing transatrial-transpulmonary repair for tetralogy of Fallot at a single institution in a low-middle income country.Methods:Medical records were retrospectively reviewed for 532 consecutive patients who underwent definitive repair of tetralogy of Fallot at our institution from 2010 to 2020.Results:The median age and weight of patients in the study patients were 11.6 months (interquartile range, 8.6–17.2 months) and 7.5 kg (interquartile range, 6.8-8.8 kg). The pulmonary valve annulus was preserved (no transannular patch) in 398 patients (75%) and a mini-transannular patch was utilized for 134 patients (25%). The overall survival was 98% at 1 year, and 97% at 10-years follow-up, respectively. Longer postoperative ventilation time was the only risk factor correlated to early death (p = 0.004; Odds Risk, 1.04; 95% confidence intervals, 1.01–1.07). Fourteen patients required pulmonary valve replacement (2.6%, 14/532), four required surgical resection to relieve right ventricular outflow tract obstruction (0.8%, 4/532), and freedom from reoperation of the right ventricular outflow tract was 87% at 10 years. The only risk factor for right ventricular outflow tract reoperation was a postoperative systolic pressure gradient through the right ventricular outflow tract of greater than 50 mmHg (p < 0.001; HR, 47; 95% confidence intervals, 9.1–244). In total, 94.6% (471/489) of the patients were asymptomatic at the latest follow-up without significant arrhythmia.Conclusion:At our institution in an low-middle income country, the transatrial-transpulmonary repair for tetralogy of Fallot has excellent midterm results with few reoperations required. Close long-term follow-up is essential for patients who undergo repair with a mini-transannular patch and may eventually require pulmonary valve replacement.
A multi-centre randomised control trial of directly observed therapy to promote medication adherence in paediatric heart transplant recipients
Authors: Killian Michael O. , Mayewski Sonnie , Gupta Dipankar 
Published: April 2024

AbstractMedication non-adherence remains a significant challenge for adolescent heart transplant recipients. Building on the success of a pilot intervention study, herein we describe the protocol for a follow-up randomised control trial using mobile video directly observed therapy, featuring several innovations, to promote medication adherence in a multi-centre sample of adolescent heart transplant patients.
Assessing primary healthcare disaster preparedness: a study in Northern Italy
Authors: Lamberti-Castronuovo Alessandro , Lamine Hamdi , Valente Martina , Hubloue Ives , Barone-Adesi Francesco , Ragazzoni Luca 
Published: April 2024

Abstract

Aim:
The aim of this paper is to outline the steps taken to develop an operational checklist to assess primary healthcare (PHC) all-hazards disaster preparedness. It then describes a study testing the applicability of the checklist.

Background:
A PHC approach is an essential foundation for health emergency and disaster risk management (H-EDRM) because it can prevent and mitigate risks prior to disasters and support an effective response and recovery, thereby contributing to communities’ and countries’ resilience across the continuum of the disaster cycle. This approach is in line with the H-EDRM framework, published by the World Health Organization (WHO) in 2019, which emphasizes a whole-of-health system approach in disaster management and highlights the importance of integrating PHC into countries’ H-EDRM. Nevertheless, literature focusing on how to practically integrate PHC into disaster management, both at the facility and at the policy level, is in its infancy. As of yet, there is no standardized, validated way to assess the specific characteristics that render PHC prepared for disasters nor a method to evaluate its role in H-EDRM.

Methods:
The checklist was developed through an iterative process that leveraged academic literature and expert consultations at different stages of the elaboration process. It was then used to assess primary care facilities in a province in Italy.

Findings:
The checklist offers a practical instrument for assessing and enhancing PHC disaster preparedness and for improving planning, coordination, and funding allocation. The study identified three critical areas for improvement in the province’s PHC disaster preparedness. First, primary care teams should be more interdisciplinary. Second, primary care services should be more thoroughly integrated into the broader health system. Third, there is a notable lack of awareness of H-EDRM principles among PHC professionals. In the future, the checklist can be elaborated into a weighted tool to be more broadly applicable.
The effects of virtual reality interventions on occupational participation and distress from symptoms in palliative care patients: A pilot study
Authors: Corvin Julian , Hoskinson Zara , Mozolic-Staunton Beth , Hattingh Laetitia , Plumbridge-Jones Russell 
Published: April 2024

AbstractBackgroundVirtual reality (VR) offers the prospect of a safe and effective adjunct therapeutic modality to promote mental health and reduce distress from symptoms in palliative care patients. Common physiological and psychological symptoms experienced at the end of life may impact the person’s participation in day-to-day activities that bring them meaning. The purpose of this study was to examine the effect of VR interventions on occupational participation and distress from symptoms.ObjectivesTo describe the stimulus, results, and learnings from a single-site pilot study of virtual reality therapy in a specialist palliative care setting.MethodsParticipants engaged in a VR session lasting from 9 to 30 minutes related to coping with pain, inner peace and mindfulness, adventure, and bucket list.Methods measuresThe pilot prospective quantitative observational cohort study was conducted from November 2021 through March 2022 using a pre-post VR intervention research design. Quantitative data was collected using patient-rated assessments and a wireless pulse oximeter. Occupational performance, satisfaction, and distress symptoms were measured using the Canadian Occupational Performance Measure and the Palliative Care Outcomes Collaboration Symptom Assessment Scale (PCOC SAS). The intervention and study design adhered to international guidelines.ResultsTen participants engaged in the VR interventions. Data showed significantly improved occupational performance and satisfaction scores (p < .001), decreases in PCOC SAS distress from pain (p = .01), fatigue (p < .001), and heart rate (p = .018). No adverse side effects were observed.Significance of resultsOutcomes included an analysis of virtual reality’s effectiveness to alleviate symptom burden and increase occupational participation for palliative care patients. Of specific interest to the research team was the application of virtual reality in a community–based and inpatient palliative care context to supplement allied health services and its feasibility of integration into standard palliative care.ConclusionVR therapy showed positive improvements in the participants’ occupational performance, satisfaction, and distress from pain and fatigue.