bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical significance of extrahepatic bile duct resection for advanced gallbladder cancer
Authors: Sakamoto Yoshihiro , Kosuge Tomoo , Shimada Kazuaki , Sano Tsuyoshi , Hibi Taizo , Yamamoto Junji , Takayama Tadatoshi , Makuuchi Masatoshi 
Published: August 2006

AbstractBackground and ObjectivesThe aim of this study was to determine the clinical significance of extrahepatic bile duct (EHBD) resection during surgery for advanced gallbladder cancer.MethodsAmong 110 patients with pT2 or higher grade gallbladder cancer, 58 patients without microscopic invasion to the EHBD were reviewed. Prognostic factors of the 58 patients were evaluated by multivariate analysis. The impact of EHBD resection on survival was assessed in relation to two prognostic determinants: (i) lymph node metastasis: positive (n = 23) and negative (n = 35); (ii) perineural invasion: positive (n = 25) and negative (n = 33).ResultsHepatic metastasis and perineural invasion were found to be independently significant prognostic factors. (i) No survival benefit of additional EHBD resection could be confirmed in each group of patients with or without nodal metastasis. (ii) In 25 patients with perineural invasion, 14 patients who underwent EHBD resection showed better survival as compared to the 11 patients who did not undergo EHBD resection (5‐year survival rate, 46% vs. 0%,P = 0.009). In the remaining 33 patients without perineural invasion, the additional EHBD resection did not yield significant improvement of survival (P = 0.28).ConclusionsResection of EHBD may offer prognostic advantage when perineural invasion exists, even in the absence of biliary infiltration. J. Surg. Oncol. 2006;94:298–306. © 2006 Wiley‐Liss, Inc.
Radical surgery‐peritonectomy and intraoperative intraperitoneal chemotherapy for the treatment of peritoneal carcinomatosis in recurrent or primary ovarian cancer
Authors: Rufián Sebastián , Muñoz‐Casares Francisco C. , Briceño Javier , Díaz Carlos J. , Rubio María J. , Ortega Rosa , Ciria Rubén , Morillo Manuel , Aranda Enrique , Muntané Jordi , Pera Carlos 
Published: August 2006

AbstractBackground and ObjectivesAdvanced ovarian cancer typically spreads in a diffuse intra‐abdominal fashion. This characteristic suggests that combined radical surgery and intraperitoneal chemotherapy may be a useful treatment procedure. The purpose of this study was to review patients submitted to surgical debulking and hyperthermic intraoperative intraperitoneal chemotherapy (HIIC) and to evaluate the potential prognostic survival factors for advanced epithelial ovarian cancer in our center.MethodsA series of patients (N = 33) diagnosed of peritoneal carcinomatosis for epithelial ovarian cancer (stage III) from January 1997 to December 2004 submitted to radical surgery‐peritonectomy and HIIC with paclitaxel was included in this study; 19 primary ovarian cancer and 14 recurrent ovarian cancer.ResultsCytoreduction R0 (P = 0.018) and negative lymph nodes (P = 0.005) were covariables for major prognostic survival. Patients with optimal cytoreduction R0 obtained survival rates of 63% at 5 years in recurrent ovarian cancer and 60% in primary ovarian cancer, 71% and 63%, respectively with associated subtotal infra‐abdominal peritonectomy, and even better results if negative lymph nodes.ConclusionsRadical surgery‐peritonectomy with HIIQ has been shown to be a surgical procedure with high tolerability, low morbimortality, enhanced survival, and prolonged disease‐free interval in patients with peritoneal carcinomatosis so much for recurrent or primary ovarian cancer. J. Surg. Oncol. 2006;94:316–324. © 2006 Wiley‐Liss, Inc.
The sacralised landscapes of Glencoe: from massacre to mass tourism, and back again
Authors: Knox Dan 
Published: August 2006

AbstractHistory is said to hang heavily over the dramatic mountain landscapes of Glencoe. More precisely, multiple memories of the Massacre of Glencoe dominate heritage visions and interpretations of this valley in Argyll, Scotland. This paper makes use of the example of Glencoe to illustrate the processes through which performative acts and utterances make and remake the sacralised landscapes of what some have termed ‘dark’ tourism. Through the repeated telling or citation of stories about the massacre, and about the associated Highland War, Glencoe is repeatedly fixed and figured into discourses relating to fear, terror and bloodshed. What I am keen to demonstrate is the ways in which the effects of performative utterances and acts become concretised as they are made into the stuff of history and heritage tourism. Glencoe is repeatedly figured as, fixed into and haunted by the seventeenth century through the continued operation of ideologies rooted in the Enlightenment and related to a hegemonic Highland and martial vision of Scotland. The rhetoric surrounding Glencoe today, as both a site and as a tourist product, and through which the collective remembering of the events of 1692 is enacted, is overwhelmingly related to one historic incident and the relation of that incident to a particular vision of the Scottish nation. Visitors frequently report finding the glen a haunting, frightening and menacing place: popular photography depicts dark and shaded mountainsides, abandoned settlements and memorials that evoke similar feelings. By conducting a tracing out of connections between the material landscapes of Glencoe, historical and contemporary representations of the glen, and tourist representational practices, this paper sheds some light on the performative power of language and practice through, in and over history, heritage, tourism and landscape. Copyright © 2006 John Wiley & Sons, Ltd.
Tourism development in Iraq: the need for support from international academia
Authors: McGahey Stan 
Published: August 2006

AbstractIraq is an ancient land of historical and religious sights that possesses a vibrant culture and numerous natural attractions. The northern region of Kurdistan is home to the Erbil Citadel, one of the world's oldest continuously inhabited sites (8000 years), as well as to snowcapped mountains, waterfalls and deep canyons set amidst alpine meadows and pastoral villages. This autonomous region of Iraq already receives domestic tourists from the hotter, arid regions to the south, and it hopes to soon begin attracting international tourists. As a result of its geo‐political situation and the breakdown of Iraq's tourism industry for many years, Kurdistan is in the process of developing much of its tourism industry from the beginning stages. Its development will, in turn, exert a profound influence on Iraq's overall tourism industry and the appeal of its tourism products in the international marketplace. Although professional tourism training and education are priorities, Kurdish and other Iraqi tourism academicians are likewise completely detached from their international counterparts. International tourism scholars and researchers are thus presented with a unique opportunity to provide collegial assistance in the form of teaching materials, updated curriculums, research partners and publication connections. Copyright © 2006 John Wiley & Sons, Ltd.
Antioxidants in thermally treated buckwheat groats
Authors: Zieliński Henryk , Michalska Anna , Piskuła Mariusz K. , Kozłowska Halina 
Published: August 2006

AbstractThe seeds of buckwheat (Fagopyrum esculentum Moench L.) were dehulled and then, following milling, extruded on a counter rotating, twin‐screw extruder with the different barrel temperature profiles: 120, 160, and 200°C. After extrusion cooking process, the following compounds were analyzed: free and conjugated phenolic acids, total polyphenols (TPC), tocopherols (T) and tocotrienols (T3), inositol phosphates (IP), reduced glutathione (GSH), and melatonin (MLT). The antioxidant capacity and superoxide dismutase‐like activity (SOD‐like activity) were determined in the groats and extrudates. Extrusion caused a significant decrease in all the compounds tested, except for phenolic acids. The content of IP decreased by 13%, that of GSH by 42%, and that of T + T3 by 62%. A three‐fold lower level of MLT and TPC was noted whereas the SOD‐like activity disappeared when compared to the nonextruded material. A two‐fold higher content of phenolic acids (free and released from ester bonds) was observed. In spite of the clear decrease in the investigated antioxidants, the extruded dehulled buckwheat seeds contained still significant content of bioactive compounds, which resulted in as little as an average 10% decrease of the antioxidant capacity.
Influence of rosemary (Rosmarinus officinalis, L.) on plant sterol oxidation in extra virgin olive oil
Authors: D'Evoli Laura , Huikko Laura , Lampi Anna‐Maija , Lucarini Massimo , Lombardi‐Boccia Ginevra , Nicoli Stefano , Piironen Vieno 
Published: August 2006

AbstractThe objective of this study was to investigate the potential role of rosemary compounds in inhibiting the plant sterol oxidation in extra virgin olive oil during heating. The stability of plant sterols was measured by quantification of plant sterol and sterol oxide formation upon 6 h of heating in both the extra virgin olive oil and its respective oil at 10% rosemary concentration (ROE). The total sterol and sitosterol oxide contents were determined by GC‐flame ionization detection (GC‐FID) and GC‐MS techniques, respectively. Heating experiments were carried out at 180°C for 0, 1, 3 and 6 h. The total sterol content in the extra virgin olive oil was 255 mg/100 g and that in the ROE 270 mg/100 g. Sitosterol was the most abundant sterol in both samples (50% of total sterol). The ROE showed a lower content of sitosterol oxides with respect to the extra virgin olive oil during heating: after 6 h of heating only 6.1% of sitosterol oxides were formed, while up to 11.5% of sitosterol oxidized in the extra virgin olive oil. Our findings suggested that rosemary compounds were able to counteract the oxidation of plant sterols in the extra virgin olive oil during heating, preventing formation of potentially harmful compounds to human health.
Systemic sclerosis fibroblasts inhibit in vitro angiogenesis by MMP‐12‐dependent cleavage of the endothelial cell urokinase receptor
Authors: Serratì S , Cinelli M , Margheri F , Guiducci S , Del Rosso A , Pucci M , Fibbi G , Bazzichi L , Bombardieri S , Matucci‐Cerinic M , Del Rosso M 
Published: August 2006

AbstractFailure of endothelial cells to develop new vessels in response to hypoxia is a distinctive feature of systemic sclerosis (SSc) in the avascular phase. We have previously shown that SSc endothelial cells over‐express matrix metalloproteinase‐12 (MMP‐12), which blocks angiogenesis by cleavage of the endothelial urokinase‐type plasminogen activator receptor (uPAR). In the present study, we have investigated whether over‐expression of MMP‐12 and of angiostatic factors, or hypo‐expression of angiogenic factors by SSc fibroblasts, contributes to impaired angiogenesis in SSc. Dermal fibroblasts were isolated from healthy subjects (N‐Fb) and patients with diffuse SSc (SSc‐Fb). Angiogenesis of target normal human microvascular endothelial cells (H‐MVECs) was assayed by Matrigel invasion, cell proliferation, and capillary morphogenesis. uPAR cleavage and MMP‐12 activity were evaluated by western blotting. We show that the over‐expression of MMP‐12 by SSc‐Fb determines uPAR cleavage in H‐MVECs. Conditioned medium from SSc‐Fb impaired H‐MVEC proliferation, invasion, and capillary morphogenesis. Anti‐MMP‐12 antibodies restored such impairment. Altered expression of angiostatic/angiogenic factors, including transforming growth factor β1, did not account for SSc‐Fb‐dependent impairment of angiogenesis. The over‐expression of MMP‐12 by both SSc‐Fb and SSc endothelial cells indicates that MMP‐12 over‐production may have a critical pathogenic role in SSc‐associated vascular alterations. Copyright © 2006 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Antidepressant drugs: prevalence, incidence and indication of use in general practice of Southern Italy during the years 2003–2004
Authors: Trifirò Gianluca , Barbui Corrado , Spina Edoardo , Moretti Salvatore , Tari Michele , Alacqua Marianna , Caputi Achille P , Arcoraci Vincenzo 
Published: August 2006

AbstractPurposeTo estimate 1‐year prevalence, 1‐year incidence and indication of use of antidepressant (AD) drug treatment in general practice of Southern Italy during the years 2003–2004.MethodsAmong 142 346 individuals registered in the lists of 119 general practitioners of Southern Italy, we identified users of different AD types: tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs) and other antidepressants. Annual prevalence of AD use was measured as the number of individuals receiving at least one AD prescription in the years 2003–2004, divided by the number of patients registered in the general practitioner (GP) lists. One‐year incidence of AD treatment was calculated as the number of new users of AD, divided by the number of total patients free from AD prescriptions in the previous year.ResultsOverall, 1‐year prevalence of AD use was 5.08 (95% confidence interval (CI): 4.97–5.20) per 100 inhabitants in the year 2003, with a 20% increase in 2004 (6.00, 5.88–6.13). Prevalence of SSRI use markedly increased from 3.80 (3.73–3.90) in 2003 to 4.51 (4.40–4.61) in 2004. The incidence rates of SSRI, TCA and other antidepressant use were 2.11 (2.03–2.19), 0.38 (0.35–0.41) and 0.53 (0.49–0.57) respectively. Depressive disorders were the main indication of use of any AD user (mostly for SSRI users), followed by anxious disturbances.ConclusionsSSRIs, particularly those recently marketed, have been increasingly used during the last years, mainly to treat affective disorders. Copyright © 2006 John Wiley & Sons, Ltd.
Social support and adolescent cancer survivors: a review of the literature
Authors: Decker Carol L. 
Published: August 2006

AbstractWith survival rates increasing dramatically in pediatric cancer, concern has increasingly focused on the psychosocial aspects of the cancer experience. Clearly, the experience of a cancer diagnosis and treatment of cancer places high demands on the coping of adolescents. Research has shown social support to be effective in decreasing stress and enhancing coping in adolescents facing such demands. A review and critical analysis of studies of social support in adolescent cancer survivors was conducted. The seventeen studies were mainly descriptive and exploratory in nature with social support examined for a number of outcome variables in eight of the studies. Findings from this review indicate that support from parents (especially the mother) and friends were extremely important and that the adolescents were satisfied with family support. Support from friends was described as less satisfactory. Methodological concerns of the reviewed studies include small samples and a lack of consistency in the instruments used to assess social support. Future studies of social support for adolescent cancer survivors should include larger samples to determine gender, age group, and ethnic differences and to allow the examination of social support theoretical models specific to the developmental and chronic illness situation of these adolescents. Copyright © 2006 John Wiley & Sons, Ltd.
CASSCF version of density functional theory
Authors: Nakata K. , Ukai T. , Yamanaka S. , Takada T. , Yamaguchi K. 
Published: August 2006

AbstractAn ab initio complete active space self‐consistent field (CASSCF) version of the density functional theory (DFT) approach, based on the partially interacting reference system, is presented. The working equations are similar to those of the CASSCF theory, but include the residual correlation potential. The essential superior points of CASSCF‐DFT, compared with the CAS configuration interaction (CI) DFT, are demonstrated. To this end, the potential curves and binding energies of several diatomic molecules (e.g., H2, Li2, and O2) are investigated in comparison with the experiments. The energy difference between the 6S and 6D states of the Mn atom, together with ionization potentials of Mn atoms, are investigated to demonstrate an important role of the electron repulsion effect. © 2006 Wiley Periodicals, Inc. Int J Quantum Chem, 2006
Multireference density functional theory with orbital‐dependent correlation corrections
Authors: Yamanaka Shusuke , Nakata Kazuto , Ukai Takeshi , Takada Toshikazu , Yamaguchi Kizashi 
Published: August 2006

AbstractThe features of ab initio wave function‐driven multireference (MR)‐density functional theory (DFT) approach based on the partially interacting reference system for ground and excited states are discussed from the viewpoint of a simple classification of electron correlation effects. Our previous MR‐DFT approach covers (i) structure‐free, and (ii) resonating‐type correlations, but does not include (iii) orbital‐dependent correlation effects. Indeed, the computational results of excitation energies of atoms imply that the state‐dependent correlations remain if the CASCI wave functions are used for the wave function part of MR‐DFT and semilocal correlation functional is used. Thus, we present an orbital‐dependent residual correlation for complete active space (CAS) DFT to describe type (iii) of correlation effects. © 2006 Wiley Periodicals, Inc. Int J Quantum Chem, 2006
Resonating broken‐symmetry approach to biradicals and polyradicals
Authors: Takeda R. , Yamanaka S. , Yamaguchi K. 
Published: August 2006

AbstractWe present a resonating broken‐symmetry (RBS) approach for strongly correlated electron systems. This is a nonorthogonal configuration interaction (CI) using symmetry‐broken Hartree–Fock (HF) references. We have applied it to the hydrogen molecule, linear hydrogen chain model systems, and to the fluorine molecule. As is known, spin contamination of biradical system with S = 1/2 can be removed by taking the resonance of two spin‐unrestricted HF (UHF) configurations. In contrast, more configurations were required to do spin projections perfectly in polyradical systems. The implications of the computational results are discussed in relation to the applicability of the RBS molecular orbital (MO) approach to more complex systems, such as metal clusters. © 2006 Wiley Periodicals, Inc. Int J Quantum Chem, 2006
Persistent increase of plasma butyryl/isobutyrylcarnitine concentrations as marker of SCAD defect and ethylmalonic encephalopathy
Authors: Merinero B. , Pérez‐Cerdá C. , Ruiz Sala P. , Ferrer I. , García M. J. , Martínez Pardo M. , Belanger‐Quintana A. , de la Mota J. L. , Martin‐Hernández E. , Vianey‐Saban C. , Bischoff C. , Gregersen N. , Ugarte M. 
Published: August 2006

SummaryHigh concentrations of butyryl/isobutyrylcarnitine (C4‐carnitine) in plasma with increase of ethylmalonic acid (EMA) in urine point to different genetic entities, and further investigations are required to differentiate the possible underlying defect. Here we report three unrelated cases, two neurologically affected and one asymptomatic, with this abnormal metabolite pattern due either to mutations in the ETHE1 gene or to a short‐chain acyl‐CoA dehydrogenase (SCAD) defect.
Bilateral nuclear cataracts as the first neonatal sign of Fanconi–Bickel syndrome
Authors: Furlan F. , Santer R. , Vismara E. , Santus F. , Sersale G. , Menni F. , Parini R. 
Published: August 2006

SummaryA patient with early bilateral nuclear cataracts and subsequent diagnosis of Fanconi–Bickel syndrome is described. Despite impaired galactose and glucose metabolism, cataracts have been reported in only few cases with this disorder. We conclude that Fanconi–Bickel syndrome should be considered in the differential diagnosis of neonatal cataracts. The pathogenesis of this complication has not been fully elucidated.
An investigation of session impact and alliance in internet based psychotherapy: Preliminary results
Authors: Reynolds D'Arcy J. , Stiles William B. , Grohol John M. 
Published: August 2006

AbstractAlthough psychotherapy has been and continues to be a face‐to‐face activity primarily, a growing minority of therapists are conducting text‐based (i.e. e‐mail) psychotherapy over the Internet. This study compared the session impact (measured by the Session Evaluation Questionnaire, SEQ; Stiles, Gordon, & Lani, 2002) and the client‐therapist alliance (measured by the Agnew Relationship Measure, ARM; Agnew‐Davies, Stiles, Hardy, Barkham, & Shapiro, 1998) of the exchanges between clients and therapists who are engaged in e‐mail therapy with previously published results on face‐to‐face therapy. According to preliminary results, the online clients provided similar session impact and therapeutic alliance ratings compared to face‐to‐face clients. Although online therapists followed this general trend, they evaluated the depth, smoothness, and positivity aspects of session impact and confidence aspect of therapeutic alliance more highly than face‐to‐face therapists.
2,2,2‐Trifluoroethanol‐Induced structural change of peanut agglutinin at different pH: A comparative account
Authors: Dev Sagarika , Khan R. H. , Surolia Avadhesha 
Published: August 2006

AbstractPeanut Agglutinin (PNA) is a legume lectin with a unique open quarternary structure. It is a homotetrameric protein, the monomeric subunit of which is made up of 3 β sheets. The structural change in this protein has been induced by 2,2,2‐trifluoroethanol (TFE) at two different pH. At neutral pH, PNA exists as a homotetramer, while at pH 2.5, it is known to dissociate to a dimer. The effect of TFE has been studied at both the pH by intrinsic tryptophan fluorescence, far and near UV Circular Dichroism, ANS binding and dynamic light scattering. At low pH, 15% TFE is found to induce a molten globule like state that shows maximum ANS binding. Increasing concentration of TFE increases α helical content and the compactness of the protein. The compact PNA at higher concentration of TFE is structurally different from the native structure. The effect of TFE at neutral pH on PNA is somewhat different from that observed at low pH. TFE does not induce molten globule like state at this pH. The detailed study of the structural change of PNA by TFE has been presented.
iubmbLife, 58: 473 ‐ 479, 2006
Cellular signalling by sphingosine kinase and sphingosine 1‐phosphate
Authors: Leclercq Tamara M. , Pitson Stuart M. 
Published: August 2006

AbstractSphingosine kinases, through the formation of the bioactive phospholipid sphingosine 1‐phosphate, have been implicated in a diverse range of cellular processes, including cell proliferation, apoptosis, calcium homeostasis, angiogenesis and vascular maturation. The last few years have seen a number of significant advances in understanding of the mechanisms of action, activation, cellular localisation and biological roles of these enzymes. Here we review the current understanding of the regulation of and cellular signalling by sphingosine kinase and sphingosine 1‐phosphate and discuss recent findings implicating sphingosine kinase as a potential therapeutic target for the control of cancer, inflammation and a number of other diseases. We suggest that, since the activation and subcellular localization of these enzymes appear to play critical roles in their biological functions, targeting these processes may provide more specific therapeutic options than direct catalytic inhibitors.
iubmb Life, 58: 467 ‐ 472, 2006