bluuebunny/crossref_metadata_2025_split huggingface dataset:
A microenvironment-modulating dressing with proliferative degradants for the healing of diabetic wounds
Authors: Luo Liang , Cheng Lianghui , Zhuang Zhiyong , Yin Mingming , Lu Yuan , Liu Sujuan , Zhan Minle , Zhao Liyuan , He Zhenyan , Meng Fanling , Tian Sidan 
Published: April 2024

Abstract

Diabetic wounds are usually entangled in a disorganized and self-perpetuating microenvironment and accompanied by a prolonged delay in tissue repair. Sustained and coordinated microenvironment regulation and tissue regeneration are key to the healing process of diabetic wounds, yet they continue to pose a formidable challenge. Here we report a rational double-layered dressing design based on chitosan and a degradable conjugated polymer polydiacetylene, poly(deca-4,6-diynedioic acid) (PDDA), that can meet this intricate requirement. With an alternating ene-yne backbone, PDDA degrades when reacting with various types of reactive oxygen species (ROS), and more importantly, generates proliferative succinic acid as a major degradant. Inheriting from PDDA, the developed PDDA-chitosan dressing PCD can eliminate ROS in the microenvironment of diabetic wounds, alleviate inflammation, and downregulate gene expression of innate immune receptors. PCD degradation also triggers simultaneous release of succinic acid in a sustainable manner, enabling long-term promotion on tissue regeneration. We have validated the biocompatibility and excellent performance of PCD in expediting the wound healing on both diabetic mouse and porcine models, which underscores the significant translational potential of this microenvironment-modulating, growth-promoting wound dressing in diabetic wounds care.
Relaxation of mucosal fibronectin fibers in late gut inflammation following neutrophil infiltration in mice
Authors: Rappold Ronja , Kalogeropoulus Konstantinos , Keller Ulrich auf dem , Slack Emma , Vogel Viola 
Published: April 2024

Abstract
The continuously remodeled extracellular matrix (ECM) plays a pivotal role in gastrointestinal health and disease, yet its precise functions remain elusive. In this study, we employed laser capture microdissection combined with low-input proteomics to investigate ECM remodeling during Salmonella-driven inflammation. We also probed the mechanosensitive state of fibronectin, a crucial ECM component with diverse functions dependent on its tensile state. While fibronectin fibers in healthy intestinal tissue are typically stretched, we demonstrated their relaxation only hours after infection in intestinal smooth muscles, despite the absence of bacteria in that area. In contrast, within the mucosa, where Salmonella is present starting 12 hours post-infection, fibronectin fiber relaxation occured exclusively during late-stage infection at 72 hours, and was localized to neutrophil clusters. Using N-terminomics, we identified three new cleavage sites in fibronectin in the inflamed cecum. Our work suggests that the ECM remodeling responses of different tissue layers in the intestine are distinct and carefully orchestrated.
Biogas Production from Different Food Waste Using Small-Scale Floating Drum Type Anaerobic Digester
Authors: Shehata Moustafa , Elsayed Yasser , Mohamed Ayman Mohamed Ibrahim , Ismail Mohammed , Walker Mark , Ibrahim Ibrahim Abdel-Rahman 
Published: April 2024

Abstract

The generation of food waste poses an escalating societal challenge. Anaerobic digestion emerges as a sustainable and eco-friendly method for valorization and disposal. A small-scale floating drum-type digester was developed, operating in batch mode to harness biogas from three distinct food waste categories. Potato Waste (PW), Leftover Cooked Food (LCF), and Fish Waste (FW) were utilized as feedstock, maintained at an average temperature of 21°C for a retention time of 10 days, with cow manure serving as the inoculum source. The advances of the current work are built upon comparing biogas production volume and methane content from mono-anaerobic digestion of these various wastes. Examination of cow manure and different substrate samples offers insights into their composition, encompassing total solids, C/N ratio, and pH. Shredded raw wastes were wet-fed into the digester at a 1:1 waste/water ratio. Cumulative production of biogas and the methane fraction were monitored. The maximum cumulative biogas production per kg of waste was observed for LCF (73.5 L/kgWW), followed by FW (53 L/kgWW) and PW (37 L/kgWW). The maxium methane percentage occurred on the 7th to 8th day, with FW displaying the highest methane percentage (72%), trailed by LCF (54.6%) and PW (56%).
A Statement of Novelty
The novelty of this study lies in its multifaceted approach towards enhancing biogas production through mono-digestion of various organic waste materials. By focusing on the comparative analysis of these waste substrates in a controlled laboratory setting, using a simplified and efficiently designed floating drum digester, this research aims to shed light on their individual suitability for anaerobic digestion. Furthermore, the exploration extends to designing and deploying small-scale, decentralized anaerobic digestion systems tailored specifically for localized energy and waste management solutions, particularly beneficial in rural or off-grid areas. Through this integrated investigation, this study gives a comprehensive understanding of mono-digestion's contribution to biogas production and its implications for sustainable waste management practices.
Humoral immune response characteristics of the susceptible populations after the infection of SARS-CoV-2 BA.5 strain
Authors: Zhang Huan , Ouyang Shi , Li Zhuolin , Jiang Yushan , Peng Tingting , Xi Chang , Zhang Bao , Wu Bo , Ouyang Fen , Li Baisheng , Zhao Wei , Shen Chenguang 
Published: April 2024

Abstract

This study compared the humoral immune characteristics of children, elderly people, pregnant women, and adults infected with BA.5 and XBB strains in Guangzhou, China. It was found that binding and neutralizing antibodies the titers against distinct SARS-CoV-2 strains were low in the acute-phase sera of BA.5 infected patients, while the corresponding titers were significantly increased in the convalescent phase, the antibody titers against the Wuhan strain were the highest. Regardless of whether they were vaccinated, BA.5 infection did not induce high neutralizing antibodies against XBB. During the recovery phase, the titers of antiviral antibodies in the vaccinated population are more robust than those in the unvaccinated population. For BA.5 infections, the specific binding and neutralizing antibody titers in the children group were lower compared to other population groups. In the convalescence period of the disease, the titers of neutralizing antibodies against Wuhan, BA.5 and XBB strains induced by BA.5 infections are significantly correlated in pairs. XBB can induce a broader and balanced antiviral humoral immune response than BA.5 as a first-time infected strain. This finding can provide a reference for the judgment of the future epidemic law of SARS-CoV-2, and provide a scientific basis for developing novel COVID-19 vaccines, especially for discovering customized vaccines and immune strategies for different populations.
Modeling and Evaluating Passenger Evacuation and Risk in Blended Wing Body Aircraft Using Continuous Displacement Agents
Authors: Chen Kun , Wang Xiaotian , Li Pengfei , Xie Jiang 
Published: April 2024

Abstract
In the aviation industry, ensuring efficient emergency evacuation procedures remains paramount for passenger safety. This research endeavors to investigate the evacuation efficacy of Blended Wing Body (BWB) aircraft, evaluating their operational efficiency and practicality during emergency situations through the development of a continuous displacement field evacuation model compliant with airworthiness standards. Twelve carefully constructed experiments were conducted to refine the simulation model, enabling a comprehensive evaluation of BWB aircraft evacuation performance across diverse scenarios. The findings suggest commendable evacuation performance of BWB aircraft, underscored by the significant impact of accurate crew guidance on evacuation efficiency. Furthermore, a positive correlation between Operational Performance Standards (OPS) values and evacuation duration underscores the pivotal role of evacuation protocols. Notably, BWB aircraft necessitate special consideration for scenarios involving inaccessible rear exits, unlike conventional aircraft. This study not only illuminates the strengths and limitations of BWB aircraft evacuation protocols but also furnishes actionable insights for regulatory bodies, aircraft manufacturers, and airlines to enhance emergency readiness and passenger safety.
Effects of exogenous calcium and calcium inhibitor on physiological characteristics of winter rape (Brassica rapa) under low temperature stress
Authors: Wu Junyan , Pan Qiaowen , Muhammad Fahim Abbas , Zhang Lulu , Liu Lijun , Yang Gang , Wang Wangtian , Pu Yuanyuan , Fang Yan , Ma Li , Sun Wancang 
Published: April 2024

Abstract

Low temperature is one of the environmental factors that restrict the growth and geographical distribution of brassica. To investigate the effects of exogenous calcium and calcium inhibitors on the ability of winter rapeseed (Brassica rapa L.) to withstand low temperatures, and its effect on physiological characteristics we used a strong cold-resistant Longyou 7 (L7) and a weak cold-resistant Longyou 99 (L99) cultivar. The seedlings were treated with CaCl2 (20 mmol·L-1) and the calcium inhibitor LaCl3 (10 mmol·L-1) at 0 h, 6 h, 12 h, 24 h and 48 h, the Ca2+ flux and Ca2+ concentration in the roots after 12 h and 24 h of treatment were analyzed, and results after low-temperature treatment, L99 showed Ca2+ efflux with a rate of 30.21 pmol‧cm-2‧s-1, whereas L7 briefly showed efflux then returned to influx. Moreover. our findings illustrate that under low-temperature conditions, the activities of superoxide dismutase (SOD), peroxidase (POD), and catalase (CAT) were increased by both CK and exogenous CaCl2 treatments. The contents of soluble protein (SP) and proline (Pro) were increased, while the contents of malondialdehyde (MDA) were decreased, resulting in reduced membrane lipid peroxidation. But enzyme activity decreased and MDA content increased following treatment with exogenous LaCl3. The rate of Ca2+ flow showed a higher uptake in L7 roots compared with L99. Calcium ion content in root showed a decrease in ion content in both cultivars after CaCl2 treatment. The results of RNA-seq data revealed that the genes that are differentially expressed in response to low temperatures, hormones, photosystem II, chloroplasts, DNA replication, ribosomal RNA processing, and translation were significantly enriched. This study found significant expression of genes related to cellular signal transduction (MAPK signaling pathway) and material metabolism (nitrogen metabolism, glycerol ester metabolism). The analysis of MAPK signaling pathway and genes in two modules led to the screening of 8 candidate genes related to the regulation of root growth, development and signal transduction.
National assessment of regional sustainability across the United States
Authors: Chapman Eric , Carter Maddison , Harvey Jada , Hatch Ashley , Lucero Clara , Rogers Lauren 
Published: April 2024

Abstract
Industrial agriculture, climate change, biodiversity loss, global conflict, and increasing inequality undermine the life-supporting services provided by our planet. Recently, the global community has started developing frameworks aimed at averting a climate catastrophe. Global agreements are undoubtedly instrumental in providing humanity with a roadmap for sustainable transformation, but policies to affect national and regional change are needed. Here, we argue that regional sustainable transformation is an actionable way to work toward global sustainability. We used the Doughnut Model (DM) and compiled a database of 8 ecological ceiling metrics and 12 social foundation metrics to assess regional sustainability across 32 metro areas and 180 counties in the United States representing roughly 35% of the US population. Using targeted keywords, we reviewed county-level websites to assess to what extent urban and rural counties collaborate on regional sustainable transformation. Finally, we provide two case studies of regional sustainable transformation across urban and rural regions. We found that generally urban areas had lower social foundation deficits (6 of 12 metrics) and higher ecological ceiling overshoot (3 of 8 metrics) compared to rural areas. We also found low levels (16 out of 180 counties) of cross county collaboration between urban and rural counties for sustainability transformation. Disparities across and between urban and rural areas highlight the potential for cross county collaborative programming to increase regional sustainability. We end with a call for increased private and public funding to develop and maintain programs focused on sustainable transformation and increased cross-county collaboration between urban and rural areas.
The complete genome and phylogenetic relatedness of a newly discovered fusagra-like virus infecting Carica papaya in Ecuador
Authors: Cornejo-Franco Juan F. , Reyes-Proaño Edison , Alvarez-Quinto Robert A. , Flores Francisco J. , quito-avila diego fernando 
Published: April 2024

Abstract
A new fusagra-like virus infecting papaya (Carica papaya L.) was genetically characterized. The genome of the virus, provisionally named ‘papaya sticky fruit-associated virus (PSFaV)’, comprises a single double-stranded RNA molecule of 9,199 nucleotides (nt) containing two discontinuous open reading frames. Pairwise sequence comparisons based on complete RNA-dependent-RNA-polymerase (RdRp) sequences revealed identities of 79.4% and 83.3% at the nt and amino acid (aa) levels, respectively, with babaco meleira-like virus (BabMelV), an uncharacterized virus sequence discovered in babaco (Vasconcellea x heilbornii) in Ecuador. Additional plant-associated viruses with sequence identities in the 50% range included papaya meleira virus (PMeV) isolates from Brazil. Phylogenetic analysis based on the amino acid sequences of the capsid protein (CP), RdRp, and CP-RdRp fusion protein genes placed PSFaV in a group within a well-supported clade, which shares a recent ancestor with Sclerotium rolfsii RNA virus 2 and Phlebiopsis gigantea mycovirus dsRNA 2, two fungi-associated fusagraviruses. Genomic features and phylogenetic relatedness suggest that PSFaV, along with its closest relative BabMelV, represent a novel plant-associated virus classified within the proposed fusagraviridae family.
Passive Control of Shock-Wave/Turbulent Boundary-Layer Interaction Using Spanwise Heterogeneous Roughness
Authors: Wu Wencan , Laguarda Luis , Modesti Davide , Hickel Stefan 
Published: April 2024

Abstract

A novel passive flow-control method for shock-wave/turbulent boundary-layer interactions (STBLI) is investigated. The method relies on a structured roughness pattern constituted by streamwise-aligned ridges. Its effectiveness is assessed with wall-resolved large-eddy simulations of the interaction of a Mach 2 turbulent boundary layer flow with an oblique impinging shock with shock angle 40°. The structured roughness pattern, which is fully resolved by a cut-cell based immersed boundary method, covers the entire computational domain. Results show that this rough surface induces large-scale secondary streamwise vortices, which energize the boundary layer by transporting high-speed fluid closer to the wall. A parametric study is performed to investigate the effect of the spacing between the ridges. This investigation is further substantiated through spectral analysis and sparsity-promoting dynamic mode decomposition. We find that ridges with small spacing effectively mitigate the low-frequency unsteadiness of STBLI and slightly reduce total-pressure losses.
Advancing Clinical Decision-Making: Utilizing Machine Learning to Predict Postoperative Stroke Following Craniotomy
Authors: Lu Tianyou , Huang Qin , Luo Tongsen , Lu Yaxin , Li Liping , Cai Jun , Hei Ziqing , Chen Chaojin 
Published: April 2024

Abstract
Objection:
Postoperative stroke (PS) represents a significant and grave complication, which often remains challenging to detect until clear clinical symptoms emerge. The early identification of populations at high risk for perioperative stroke is essential for enabling timely intervention and enhancing postoperative outcomes. This study seeks to employ machine learning (ML) techniques to create a predictive model for PS following elective craniotomy.
Methods
This study encompassed a total of 1,349 cases that underwent elective craniotomy between January 2013 and August 2021. Perioperative data, encompassing demographics, etiology, laboratory results, comorbidities, and medications, were utilized to construct predictive models. Nine distinct machine learning models were developed for the prediction of postoperative stroke (PS) and assessed based on the area under the receiver-operating characteristic curve (AUC), along with sensitivity, specificity, and accuracy metrics.
Results
Among the 1,349 patients included in the study, 137 cases (10.2%) were diagnosed with postoperative stroke (PS), which was associated with a worse prognosis. Of the nine machine learning prediction models evaluated, the logistic regression (LR) model exhibited superior performance, as indicated by an area under the receiver-operating characteristic curve (AUC) value of 0.741 (0.64–0.85), and competitive performance metrics, including an accuracy of 0.668, sensitivity of 0.650, and specificity of 0.670. Notably, feature importance analysis identified "preoperative albumin," "ASA classification," and "preoperative hemoglobin" as the top three factors contributing to the prediction of PS.
Conclusion
Our study successfully developed a real-time and easily accessible parameter requiring LR-based PS prediction model for post-elective craniotomy patients.
How does social exclusion lead to emerging adult relational aggression? Potential Mechanisms of Action of Relative Deprivation and Hostile Attribution Bias
Authors: Tong Lifang , Jiang Yongzhi , Cao Wenjiao , Wang Huizhe 
Published: April 2024

Abstract

Background
Relational aggression, as a specific type of aggression in social relationships in emerging adulthood, is associated with multiple forms of physical and psychological disorders. To date, there has been a lack of systematic and in-depth research on the mechanisms underlying the emergence of relational aggression. The present study aimed to explore the effects of social exclusion on relational aggression and the potential role played by relative deprivation and hostile attributional bias in the relationship between the two.
Methods
A self-report questionnaire on social exclusion, relational aggression, relative deprivation, and hostile attributional bias was administered to 1970 Chinese students between the ages of 18 and 25 years using relevant scales.
Results
There were significant positive correlations between social exclusion, relational aggression, relative deprivation, and hostile attributional bias; relative deprivation mediated the relationship between social exclusion and relational aggression; and hostile attributional bias played a significant moderating role in the direct pathway between social exclusion and relational aggression. Specifically, high hostile attributional bias exacerbated the effect of social exclusion on relational aggression, whereas low hostile attributional bias weakened this mechanism of influence.
Conclusions
This study explored the mechanisms that produce relational aggression in emerging adulthood and found that social exclusion not only directly affects relational aggression but also indirectly affects relational aggression through feelings of relative deprivation. Hostile attributional bias largely moderated the effects of social exclusion on relational aggression. The results of this study not only expand the research perspectives on relational aggression but also provide a theoretical basis for the effective explanation, prevention, and intervention of malignant interpersonal relationships.
Exploring the behavioral intentions of PICC-related thrombosis prevention in breast cancer patients undergoing chemotherapy: a qualitative study based on theory of planned behavior
Authors: Zhang Ning , Xu Yuan , Lu Qiaodan , Zhu Liyun , An Ranxun , Zhou Xinyi , Wang Yu , Ma Yufen , Deng Haibo , Guo Hailing , Wang Lei , Sun Jianhua , Bo Haixin , Wang Xiaojie 
Published: April 2024

Abstract

Purpose
To explores the behavioral intention of breast cancer patients undergoing chemotherapy to prevent PICC-related thrombosis based on the Theory of Planned Behavior.
Methods
This qualitative study employed purposive sampling and conducted semi-structured interviews with 14 breast cancer patients undergoing chemotherapy in the outpatient chemotherapy ward of a tertiary A-level comprehensive hospital in Beijing from July to August 2023. Data were analyzed using Colaizzi's descriptive analysis framework.
Results
Data analysis identified 10 themes were derived from 4 aspects. Regarding behavioral attitude, three themes were condensed: (1) Considering the benefits of preventive measures, (2) Simple and easy preventive measures, (3) Underestimating the importance of PICC-related thrombosis prophylaxis. Subjective norms yielded two main themes and five sub-themes: (1) Support from those close to the patient motivates adherence to prophylaxis (Support from the patient's family, healthcare professionals, other patients), (2) Patients are influenced by personal factors to form an internal driving force (physical symptoms, Fear of PICC-related thrombosis). Regarding perceived behavioral control, three main themes and four sub-themes were extracted: (1) Obstacles before actual prevention exercise (Prevention information, Hard to remember information), (2) Forgetfulness is the main obstacle factor, (3) Wanting to overcome barriers to adhere to regular prevention (Confidence to overcome obstacles, Hope to get support).
Conclusions
Breast cancer patients undergoing chemotherapy are difficult to accurately remember the prevention knowledge and prone to forgetfulness in the prevention of PICC-related thrombosis, which leads to the poor overall prevention compliance and suboptimal preventive effects. Interventions to address the preventive compliance problems of patient should be developed in three areas: the patients themselves, the supporters around the patient and the healthcare professionals.