bluuebunny/crossref_metadata_2025_split huggingface dataset:
Amniotic trisomy 11 mosaicism—is it a benign finding?
Authors: Basel‐Vanagaite Lina , Davidov Bella , Friedman Jane , Yeshaya Yosefa , Magal Nurit , Drasinover Valerie , Shohat Mordechai 
Published: June 2006

AbstractObjectivesA case of prenatally diagnosed trisomy 11 mosaicism with a normal outcome is reported and the medical literature on prenatal detection of this finding is reviewed.MethodsProportion of cells with trisomy 11 was evaluated in amniocytes, fetal blood lymphocytes, newborn fibroblasts and urinary epithelial cells. Karyotype studies and fluorescence in situ hybridization analysis using the 11q13LS1 CCND1 probe were performed.ResultsTrisomy 11 level III mosaicism of 26% was detected in amniotic fluid cells. Periumbilical blood sampling showed a normal fetal karyotype. No fetal structural abnormalities were noted on ultrasound scan. The infant was spontaneously delivered and had normal physical findings at birth. No evidence of trisomic cells was found on extensive postnatal evaluation, implying an extraembryonic origin. Molecular analysis excluded uniparental disomy of chromosome 11. At 1 year of age, the baby is developing normally.ConclusionsOnly three reports on trisomy 11 mosaicism identified at amniocentesis have been published previously, all with a normal outcome. Additional cases of prenatally diagnosed mosaicism for trisomy 11 are necessary to assess more accurately the clinical significance of this finding. Copyright © 2006 John Wiley & Sons, Ltd.
Calreticulin induces delayed cardioprotection through mitogen‐activated protein kinases
Authors: Liu Xiuhua , Xu Feifei , Fu Yan , Liu Fengying , Sun Sheng , Wu Xudong 
Published: June 2006

AbstractHypoxic preconditioning (HPC) attenuates tissue injury caused by ischemia/reperfusion. The protective mechanisms of HPC involve up‐regulation of the protective proteins and mitigation of cellular calcium overload. Calreticulin (CRT), a Ca2+‐binding chaperone, plays an important role in regulating calcium homeostasis and folding of proteins. The role of CRT in cardioprotection of HPC and the pathways determining CRT expression during HPC are not clear. In this work, 2‐DE and MALDI‐MS were employed to analyze CRT differential expression in cardiomyocytes subjected to transient hypoxia. Western blotting analysis was used to detect the CRT expression and activities of p38 mitogen‐activated protein kinase (p38 MAPK) and c‐Jun NH2‐terminal kinase (JNK) in myocardium subjected to ischemia with and without HPC and sham operation. The hearts from HPC group were more resistant to sustained ischemia and had much stronger phosphorylation of p38 MAPK, with a reduced phosphorylation of JNK, than controls. The CRT expression was positively correlated with the phosphorylation of p38 MAPK and negatively correlated with the level of JNK phosphorylation. Furthermore, inhibition of the p38 MAPK with SB202190 abolished, while inhibition of the JNK with SP600125 enhanced the CRT up‐regulation in cardiomyocytes induced by HPC. The results indicate that HPC up‐regulates CRT expression through the MAPK signaling pathways.
Scaling analysis of cotton cellulose/LiCl·DMAc solution using light scattering and rheological measurements
Authors: Aono Hajime , Tatsumi Daisuke , Matsumoto Takayoshi 
Published: June 2006

AbstractSemidilute solution of cotton lint (CC1) in 8 wt % LiCl/N,N‐dimethylacetamide was investigated using static light scattering (SLS) and rheological measurements. The reduced osmotic modulus estimated by SLS measurements for CC1 solutions are proportional to c1.16 in the semidilute region. From the exponent of 1.16, de Gennes' scaling theory derives the relationship between radius of gyration, Rg, and molecular weight, Mw, of CC1 as Rg ∝ M0.62 This corresponds to the Mark‐Houwink‐Sakurada exponent of 0.86. This exponent is very close to that estimated from scaling analysis of zero shear rate viscosity, that is 0.85. Apparent radius of gyration, Rg,app, estimated by SLS measurements for CC1 solutions are proportional to c−0.5 in the semidilute region. Rg,app indicates the mesh size of polymer entanglement in the semidilute region. On the assumption of the Gaussian behavior of CC1 molecule in the semidilute region, the exponent of −0.5 gives the relationship between the molar mass between entanglements, Me, and c as following relationship: Me ∝ c−1. This agrees with the concentration dependence on plateau modulus estimated from the dynamic viscoelastic measurements. © 2006 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 44: 2155–2160, 2006
Venting of a runaway organic peroxide decomposition in viscous solvents on pilot scale
Authors: Snee T.J. , Cuscó L. , Hare J.A. , Kerr D.C. , Royle M. 
Published: June 2006

AbstractRunaway reactions continue to occur in polymerization reactors, which are widely used in the chemical industry. Those of greatest concern include highly viscous multiphase mixtures. Considerable uncertainties exist in the design of emergency pressure‐relief systems for such reactors because there are only limited experimental data available on the flow of such fluids in relief systems.Venting experiments are reported here that have been carried out in a 350 L pilot‐scale reactor for the runaway decomposition of an organic peroxide in xylene solvent, with batch volumes of 150 and 200 L and with a range of concentrations of polystyrene dissolved in the xylene to modify the viscosity. Measurements were made of pressures in the reactor, vent line, and catch tank; temperatures at different levels in the reactor and in the vent line and catch tank; viscosity in the reactor; mass in the catch tank; and two‐phase density in the vent line.Analysis of the results shows that the venting behavior of a high‐viscosity reaction system is complex. There is no simple relationship between maximum pressure and viscosity. The results indicate that the flow regime in the reactor is influenced by the fluid viscosity and that this is of primary importance in explaining the effects on maximum pressure. © Crown Copyright 2006. Published with the permission of the Controller of HMSO and the Queen's printer for Scotland. Process Saf Prog, 2006
Phonon drag induced by Einstein mode in ZrB12
Authors: Glushkov V. , Ignatov M. , Demishev S. , Filippov V. , Flachbart K. , Ishchenko T. , Kuznetsov A. , Samarin N. , Shitsevalova N. , Sluchanko N. 
Published: June 2006

AbstractWe report on the first measurements of the Seebeck effect for single crystals of superconductor ZrB12 (T c ≈ 6.1 K) at temperatures 2.5–300 K in magnetic fields H 0 < 1 kOe. The experimental data evidently prove that the Seebeck coefficient S (T ) at T > 20 K is controlled by the electron coupling to a soft phonon Einstein mode having the characteristic energy Θ E = ħω E/k B ≈ 216 K. The origin of the S (T ) anomalies detected in the temperature interval T < 11 K is discussed in terms of the electron DOS renormalization and the superconductivity in ZrB12. (© 2006 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Detection of reactive free radicals derived from nucleosides by liquid chromatography coupled to tandem mass spectrometry of DMPO spin trapping adducts
Authors: Maurel Vincent , Ravanat Jean‐Luc , Gambarelli Serge 
Published: June 2006

AbstractIn this study, reactive free radicals derived from several nucleosides were spin trapped by 5,5‐dimethyl‐1‐pyrroline N‐oxide (DMPO) and then detected by high‐performance liquid chromatography coupled to electrospray ionization tandem mass spectrometry (HPLC/ESI‐MS/MS). This method provides a specific detection of spin trapping adducts derived from nucleosides with a very high sensitivity: quantities as low as 0.5 picomoles of spin trapping adducts corresponding to concentrations of 2.5 10−8 mol . L−1 were detected. Different spin trapping adducts were characterized by HPLC/ESI‐MS/MS in three well‐known systems producing free radicals photochemically: the photolysis of 5‐halo‐2′‐deoxyuridines, the photolysis of 5‐thiophenylmethyl‐2′‐deoxyuridine and the photolysis of thymidine with menadione bisulfite as a photosensitizer. A new radical photoreactivity of uridine derivatives was also detected by this method both at the nucleoside and at the RNA level, showing that the method is also relevant for studying spin trapping adducts derived from DNA and RNA strands. Copyright © 2006 John Wiley & Sons, Ltd.
Simultaneous quantification of chlorogenic acid and caffeic acid in rat plasma after an intravenous administration of mailuoning injection using liquid chromatography/mass spectrometry
Authors: Wang Su Jun , Zhang Zhen Qing , Zhao Yan Hong , Ruan Jin Xiu , Li Jing Lai 
Published: June 2006

AbstractA simple, rapid and sensitive method was developed for the simultaneous quantification of chlorogenic acid (CGA) and caffeic acid (CA) in rat plasma using a high‐performance liquid chromatography system coupled to a negative ion electrospray mass spectrometric analysis. The plasma sample preparation was a simple deproteinization by the addition of two volumes of acetonitrile followed by centrifugation. The analytes and internal standard ferulic acid were separated on an Intersil C8‐3 column (5 mm; 250 × 2.1 mm) with acetonitrile/0.05% triethylamine solution (70:30, v/v) as mobile phase at a flow rate of 0.2 mL/min with an operating temperature of 30°C. Detection was performed on a quadrupole mass spectrometer equipped with an electrospray ionization (ESI) source operated in selected ion monitoring (SIM) mode. Negative ion ESI was used to form deprotonated molecules at m/z 353 for chlorogenic acid, m/z 179 for caffeic acid, and m/z 193 for the internal standard ferulic acid. Linear detection responses were obtained for CGA concentrations ranging from 0.005 to 2.0 µg/mL and for CA concentrations ranging from 0.010 to 2.0 µg/mL and the lower limits of quantitation (LLOQs) for CGA and CA were 0.005 and 0.01 µg/mL, respectively. The intra‐ and inter‐day precisions (RSD%) were within 9.0% for both analytes. Deviation of the assay accuracies was within ±10.0% for both analytes. Their average recoveries were greater than 88.0%. Both analytes were proved to be stable during all sample storage, preparation and analytic procedures. The method was successfully applied to the pharmacokinetic study of CGA and CA following an intravenous dose of 5 mL/kg mailuoning injection to rats. Copyright © 2006 John Wiley & Sons, Ltd.
Impact of modelling intra‐subject variability on tests based on non‐linear mixed‐effects models in cross‐over pharmacokinetic trials with application to the interaction of tenofovir on atazanavir in HIV patients
Authors: Panhard Xavière , Taburet Anne‐Marie , Piketti Christophe , Mentré France 
Published: June 2006

AbstractWe evaluated the impact of modelling intra‐subject variability on the likelihood ratio test (LRT) and the Wald test based on non‐linear mixed effects models in pharmacokinetic interaction and bioequivalence cross‐over trials. These tests were previously found to achieve a good power but an inflated type I error when intra‐subject variability was not taken into account. Trials were simulated under H0 and several H1 and analysed with the NLME function. Different configurations of the number of subjects n and of the number of samples per subject J were evaluated for pharmacokinetic interaction and bioequivalence trials. Assuming intra‐subject variability in the model dramatically improved the type I error of both interaction tests. For the Wald test, the type I error decreased from 22, 14 and 7.7 per cent for the original (n = 12, J = 10), intermediate (n = 24, J = 5) and sparse (n = 40, J = 3) designs, respectively, down to 7.5, 6.4 and 3.5 per cent when intra‐subject variability was modelled. The LRT achieved very similar results. This improvement seemed mostly due to a better estimation of the standard error of the treatment effect. For J = 10, the type I error was found to be closer to 5 per cent when n increased when modelling intra‐subject variability. Power was satisfactory for both tests. For bioequivalence trials, the type I error of the Wald test was 6.4, 5.7 and 4.2 per cent for the original, intermediate and sparse designs, respectively, when modelling intra‐subject variability. We applied the Wald test to the pharmacokinetic interaction of tenofovir on atazanavir, a novel protease inhibitor. A significant decrease of the area under the curve of atazanavir was found when patients received tenofovir. Copyright © 2006 John Wiley & Sons, Ltd.
Long𝒞ri𝒮𝒫: a test for bump hunting in longitudinal data
Authors: Harezlak Jaroslaw , Naumova Elena , Laird Nan M. 
Published: June 2006

AbstractWe propose an extension of the Harezlak and Heckman (J. Comput. Graph. Statist.2001;10(4): 713–729) test for detecting local extrema to the longitudinal data setting. We use penalized spline regression techniques (Statist. Sci.1996;11:89–102) to provide a computationally efficient method of testing for relatively large data sets. We estimate thep‐values of our test, Long𝒞ri𝒮𝒫, with a smoothed bootstrap. Our simulation studies indicate that the test is generally conservative and has power exceeding 70 per cent at the α=0.1 nominal level in most considered settings. Finally, we apply our testing procedure to the longitudinal measurements of body mass index of former prisoners of war in Vietnam and conclude that the mean population curve exhibits non‐monotone behaviour. Copyright © 2006 John Wiley & Sons, Ltd.
Die Wupper‐Talbrücke Oehde – eine moderne Verbundbrücke
Authors: Hamme Markus , Marzahn Gero , Prehn Wolfgang , Swadlo Jutta 
Published: June 2006

AbstractDie Bundesautobahn A 1 ist eine der wichtigsten Nord‐Süd‐Verbindungen in Deutschland. Der Streckenabschnitt in Nordrhein‐Westfalen verbindet den Großraum Köln mit dem östlichen Ruhrgebiet und gehört damit zu den meistbefahrenen Streckenabschnitten. Wegen des hohen Verkehrsaufkommens ist die vorhandene vierstreifige Verkehrsführung nicht mehr ausreichend leistungsfähig, so daß die Erweiterung auf sechs Fahrstreifen als Teil des Gesamtkonzepts des sechsstreifigen Autobahnausbaus mit den Autobahnen A 1, A 2 und A 3 um das Ruhrgebiet herum erfolgt. Dadurch, daß die A 1 im Raum Wuppertal durch das Bergische Land mit seiner hügeligen Topografie geführt wird, müssen insgesamt sechs Talbrücken mit Längen zwischen 240 und 420 m erweitert werden oder neu entstehen. Die Wupper‐Talbrücke Oehde ist dabei ein bedeutendes Ingenieurbauwerk in diesem Streckenabschnitt. Als moderne Verbundkonstruktion ist sie ein ausgezeichnetes Beispiel für die guten Einsatzmöglichkeiten der Verbundbauweise im Brückenbau. (© 2006 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Geh‐ und Radwegüberführung mit ungewöhnlicher Lage bei Hornberg – Entwurf und Ausführung –
Authors: Hornecker Gustav 
Published: June 2006

AbstractIn topographisch schwierigem Umfeld wurde vom Regierungspräsidium Freiburg bei Hornberg im Schwarzwald eine behindertengerechte Geh‐ und Radwegverbindung über die Gutach realisiert. Die ungewöhnliche, symmetrische Brückenlösung besteht aus einer im Grundriß gekrümmten, mittels gespreiztem Pylon abgespannten Stahlverbundkonstruktion. Die Gestaltung, insbesondere die Krümmung im Grundriß, entwickelt sich aus der vorgebenden örtlichen Situation. Bei dem über dem Bach gespreizten Pylon wurde die Form der Krümmung als Stilelement übernommen.Im folgenden Aufsatz wird auf Fragen der Entwurfsentstehung, der Gründungsproblematik, der Konstruktion und Statik des Tragwerks und auf Fragen der Herstellung eingegangen. (© 2006 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Zum Einfluß der Interaktion von Biegemoment und Querkraft auf das Tragverhalten von Wellstegträgern
Authors: Kuchta Krzysztof 
Published: June 2006

AbstractDargestellt werden Ergebnisse Versuchsergebnisse und numerische Simulationen, die den Versagensmechanismus von Wellstegträgern unter dem Einfluß der Interaktion von Biegemoment und Querkraft beschreiben. Vorgeschlagen werden einfache Formeln zur Berücksichtigung dieser Versagensformen bei Bestimmung des Tragverhaltens von Wellstegträgern. (© 2006 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Isolation and Partial Characterisation of Native Starches of new Banana and Plantain Hybrids (Musa spp.) in Comparison with that of Plantain Variety Orishele
Authors: Coulibaly Souleymane , Nemlin Jean Gnopo , Amani Georges N'Guessan 
Published: June 2006

AbstractNative starches were extracted from four new banana hybrids (CRBP 14, CRBP 39, FHIA 17 and FHIA 21) and from Orishele, a plantain variety (Musa spp) used as control. Purity (determined by the polarimetric method), iodine complex absorption spectrum (conducted according to Garcia and Lajolo), size and shape of granules (determined with a scanning electron microscope and an optical microscope equipped with a micrometer), swelling power and solubilization patterns (determined according to Leach et al.) were the characteristics under study. For the four banana hybrids, starch purities range from 96.55 to 97.83%, whereas it stands at a medium value in the case of the control (Orishele variety). The absorption maxima of the starch‐iodine complexes for the five cultivars occurred between 620 and 630 nm, with absorption averages ranging between 1.11 and 1.85%. Again, the control variety Orishele has medium value for iodine absorption. The majority of starch granules is of oblong shape, and their lengths range from 3.33 to 56.66 µm. CRBP 14 and CRBP 39 have the largest granule sizes, followed by Orishele; hybrids FHIA 21 and FHIA 17 having the smallest sizes. At high temperatures hybrid FHIA 17 shows the lowest increase of swelling and solubilisation. This hybrid also presents the lowest setback, swelling and solubilisation values. This hybrid also has the smallest starch granule sizes together with the lowest iodine absorption. Apart from starch setback, the other three hybrids (CRBP 14, CRBP 39 and FHIA 21) show characteristics that are superior to those of the control. Hybrid FHIA 17 can be classified as of sweet banana type, whereas the three other hybrids are of plantain type.
Bishop score and ultrasound assessment of the cervix for prediction of time to onset of labor and time to delivery in prolonged pregnancy
Authors: Strobel E. , Sladkevicius P. , Rovas L. , De Smet F. , Karlsson E. Dejin , Valentin L. 
Published: June 2006

AbstractObjectivesTo determine the ability of Bishop score and sonographic cervical length to predict time to spontaneous onset of labor and time to delivery in prolonged pregnancy.MethodsNinety‐seven women underwent transvaginal ultrasound examination and palpation of the cervix at 291–296 days' gestation according to ultrasound fetometry at 12–20 weeks' gestation. Sonographic cervical length and Bishop score were recorded. Multivariate logistic regression analysis was used to determine which variables were independent predictors of the onset of labor/delivery ≤ 24 h, ≤ 48 h, and ≤ 96 h. Receiver–operating characteristics (ROC) curves were drawn to assess diagnostic performance.ResultsIn nulliparous women (n = 45), both Bishop score and sonographic cervical length predicted the onset of labor/delivery ≤ 24 h and ≤ 48 h (area under ROC curve for the onset of labor ≤ 24 h 0.79 vs. 0.80, P = 0.94; for delivery ≤ 24 h 0.81 vs. 0.85, P = 0.64; for the onset of labor ≤ 48 h 0.73 vs. 0.74, P = 0.90; for delivery ≤ 48 h 0.77 vs. 0.71, P = 0.50). Only Bishop score discriminated between nulliparous women who went into labor/delivered ≤ 96 h or > 96 h. A logistic regression model including Bishop score and cervical length was superior to Bishop score alone in predicting delivery ≤ 24 h (area under ROC curve 0.93 vs. 0.81, P = 0.03) and superior to Bishop score alone and cervical length alone in predicting the onset of labor ≤ 24 h (area under ROC curve 0.90 vs. 0.79, P = 0.06; and 0.90 vs. 0.80, P = 0.06). In parous women (n = 52), Bishop score and sonographic cervical length predicted the onset of labor/delivery ≤ 24 h (area under ROC curve for the onset of labor 0.75 vs. 0.69, P = 0.49; for delivery 0.74 vs. 0.70, P = 0.62), but only Bishop score discriminated between women who went into labor/delivered ≤ 48 h and > 48 h. Three parous women had not gone into labor and six had not given birth at 96 h. In parous women logistic regression models including both Bishop score and cervical length did not substantially improve prediction of the time to onset of labor/delivery.ConclusionsIn prolonged pregnancy Bishop score and sonographic cervical length have a similar ability to predict the time to the onset of labor and delivery. In nulliparous women the use of logistic regression models including Bishop score and cervical length is likely to offer better prediction of the onset of labor/delivery ≤ 24 h than the use of the Bishop score alone. Copyright © 2006 ISUOG. Published by John Wiley & Sons, Ltd.
Maple syrup urine disease: Favourable effect of early diagnosis by newborn screening on the neonatal course of the disease
Authors: Simon E. , Fingerhut R. , Baumkötter J. , Konstantopoulou V. , Ratschmann R. , Wendel U. 
Published: June 2006

SummaryBackground: In the rare autosomal recessive disorder maple syrup urine disease (MSUD) the accumulation of the branched‐chain amino acids and their metabolic products results in acute and chronic brain dysfunction. Since 2002, MSUD has been part of the extended newborn screening programme in Germany and Austria. Early diagnosis and intervention during the presymptomatic or early symptomatic period should improve the outcome of the patients, which would make the case for screening for MSUD. Aim: The aim of the study was to evaluate the clinical course and alterations of marker metabolites during the first weeks of life in 10 patients with classical MSUD detected by newborn screening (NBS) in comparison with the 10 youngest German patients diagnosed clinically. Method: Laboratory data as well as information on clinical course and management during the neonatal period were obtained retrospectively. Results: Patients detected in NBS presented with lower plasma leucine concentrations at confirmation of diagnosis and less severe clinical symptoms. Lowering of leucine to below a critical threshold of 1000 μmol/L was achieved earlier than in patients diagnosed on clinical grounds. Conclusion: After diagnosis in screening, treatment can be initiated before the occurrence of severe metabolic decompensation. However, a favourable effect can only be achieved with immediate transfer of the neonate to a metabolic centre for adequate treatment in case of a positive screening result.
Effect of Local Application of Cidofovir on the Control of Recurrences in Recurrent Laryngeal Papillomatosis
Authors: Pontes Paulo , Avelino Melissa , Pignatari Shirley , Weckx Luc Louis Maurice 
Published: July 2006

OBJECTIVETo study the effect of local application of cidofovir in patients with recurrent laryngeal papillomatosis (RLP) by measuring the interval between recurrences and the extent of disease at each recurrence.STUDY DESIGN AND SETTINGThe study group included 10 patients with RLP. Videolaryngoscopic analysis of previous RLP operations for each patient before starting cidofovir and the number and timing of pre‐cidofovir recurrences of the disease provided data for a self‐control group. The cidofovir was injected with a laryngeal needle during papilloma resection operations. To evaluate the changes and the extent of the disease, the authors developed a staging system based on anatomic topography. The extent of the disease and the intervals between recurrences were analyzed and statistically compared.RESULTSThe median interval between recurrences significantly increased from 102 days before cidofovir to 239 days after treatment. No local or systemic side effects were observed.CONCLUSIONSThe study supports the hypothesis that cidofovir is an effective adjunct in treating recurrences of RLP.EBM rating: C‐4