bluuebunny/crossref_metadata_2025_split huggingface dataset:
Building a maternal and child cohort amidst Lebanon’s socioeconomic collapse: preliminary results and navigating research challenges
Authors: Kaddoura Rima , Elbejjani Martine , Tamim Hani , Mahfoud Ziyad R. , Salameh Pascale , Mirza Fadi , Charafeddine Lama 
Published: March 2024

AbstractThe impact of conflict and crisis on maternal and child health underscores the need for reliable research in vulnerable populations. Lebanon, amidst ongoing economic collapse, political instability, and healthcare system strain, offers a case study for exploring these impacts, particularly on preterm babies and their development. This study aims to assess the feasibility of establishing a prospective cohort of mothers and their full-term and preterm babies in Lebanon, examining the association between social determinants, preterm birth, and developmental outcomes amidst the nation's multifaceted crises. The planned cohort involves 50 full-term and 50 preterm mother-baby pairs recruited at birth and followed up to 9–12 months post-birth. Data collection spans social determinants, perceived stress, social support, quality of life, and developmental assessments. Challenges in recruitment, follow-up, and data collection in the context of Lebanon's socio-political and economic turmoil are evaluated, alongside ethical considerations for research in vulnerable populations. Preliminary findings highlight substantial recruitment and follow-up challenges, notably due to population mobility, economic instability, and healthcare access issues. Despite these obstacles, 113 mother-baby pairs have been recruited. Early analysis reveals significant stress and reduced quality of life among mothers, particularly those with preterm infants, against a backdrop of declining birth rates and healthcare worker exodus. Conducting research in crisis settings like Lebanon presents unique methodological and ethical challenges but remains crucial for understanding and improving health outcomes in vulnerable populations. The study underscores the importance of adaptable research designs and ethical diligence in crisis research, highlighting the need for interventions tailored to these contexts. Establishing a mother and child cohort in Lebanon's crisis-ridden setting is faced with many challenges but is essential for guiding future interventions. Research in such contexts is needed to address health disparities and supporting vulnerable populations, emphasizing the need for dedicated funding and innovative research approaches in times of crisis.
Hindfoot motion according to subtalar compensation and ankle osteoarthritis stage analyzed by a multi-segment foot model
Authors: Kang Ho Won , Kim Dae-Yoo , Kim Jung Min , Park Gil Young , Lee Dong-Oh , Lee Dong Yeon 
Published: March 2024

Abstract
Background
The biomechanics of the hindfoot in ankle osteoarthritis (OA) are not yet fully understood. Here, we aimed to identify hindfoot motion in a gait analysis using a multi-segment foot model (MFM) according to ankle OA stage and the presence of subtalar compensation defined by hindfoot alignment.

Methods
We retrospectively reviewed the medical records, plain radiographs, and gait MFM data of 54 ankles admitted to our hospital for the treatment of advanced ankle OA. Spatiotemporal gait parameters and three-dimensional motions of the hindfoot segment were analyzed according to sex, age, body mass index, Takakura classification, and the presence of subtalar compensation. Twenty ankles were categorized as compensated group, and 34 ankles as decompensated group.

Results
No spatiotemporal gait parameters differed significantly according to the presence of subtalar compensation or ankle OA stage. Only normalized step width differed significantly (P = 0.028). Average hindfoot motion (decompensation vs. compensation) did not differ significantly between the sagittal and transverse planes. Graphing of the coronal movement of the hindfoot revealed collapsed curves in both groups that differed significantly. Compared with Takakura stages 3a, 3b, and 4, cases of more advanced stage 3b had a smaller sagittal range of motion than those of stage 3a (P = 0.028). Coronal movement of the hindfoot in cases of Takakura stage 3a/3b/4 showed a relatively flat pattern.

Conclusions
The spatiotemporal parameters were not affected by the hindfoot alignment resulting from subtalar compensation. The sagittal range of hindfoot motion decreased in patients with advanced ankle OA. Once disrupted, the coronal movement of the subtalar joint in ankle OA did not change regardless of ankle OA stage or hindfoot compensation state.
Cabrol procedure and its modifications: a systematic review and meta-analysis
Authors: Yang Sen , Zhang Ya-yong , Zi Yun-feng , Pu Lei , Qian Xu , Ren Le , Li Yong-bo , Jin Zhi-hao , Liu Jian-feng , Yuan Zhuo , Li Ya-Xiong 
Published: March 2024

Abstract
Background
The Cabrol procedure has undergone various modifications and developments since its invention. However, there is a notable gap in the literature regarding meta-analyses assessing it.

Methods
A systematic review and meta-analysis was conducted to evaluate the effectiveness and long-term outcomes of the Cabrol procedure and its modifications. Pooling was conducted using random effects model. Outcome events were reported as linearized occurrence rates (percentage per patient-year) with 95% confidence intervals.

Results
A total of 14 studies involving 833 patients (mean age: 50.8 years; 68.0% male) were included in this meta-analysis. The pooled all-cause early mortality was 9.0% (66 patients), and the combined rate of reoperation due to bleeding was 4.9% (17 patients). During the average 4.4-year follow-up (3,727.3 patient-years), the annual occurrence rates (linearized) for complications were as follows: 3.63% (2.79–4.73) for late mortality, 0.64% (0.35–1.16) for aortic root reoperation, 0.57% (0.25–1.31) for hemorrhage events, 0.66% (0.16–2.74) for thromboembolism, 0.60% (0.29–1.26) for endocarditis, 2.32% (1.04–5.16) for major valve-related adverse events, and 0.58% (0.34–1.00) for Cabrol-related coronary graft complications.

Conclusion
This systematic review provides evidence that the outcomes of the Cabrol procedure and its modifications are acceptable in terms of mortality, reoperation, anticoagulation, and valve-related complications, especially in Cabrol-related coronary graft complications. Notably, the majority of Cabrol procedures were performed in reoperations and complex cases. Furthermore, the design and anastomosis of the Dacron interposition graft for coronary reimplantation, considering natural anatomy and physiological hemodynamics, may promise future advancements in this field.
Disabling symptoms associated with increased axillary temperature in patients with functional hyperthermia
Authors: Oka Takakazu 
Published: March 2024

Abstract
Background
I previously reported a case of functional hyperthermia (FH) in a patient with an axillary temperature just slightly above 37.0 °C who persistently requested treatment. Because the severity of her fatigue increased remarkably when her axillary temperature increased above 37.0 °C, she felt that the temperature of 37.0 °C was disabling. In the present study, I analyzed a larger number of patients with FH to investigate the incidence of disabling symptoms with increasing body temperature, the kinds of symptoms associated with increased body temperature, and the temperatures at which these symptoms became disabling.

Main body
Twenty patients with FH (7 men, 13 women; mean age ± standard deviation, 31.2 ± 10.9 years) who visited my department were asked whether they had any disabling symptoms associated with an increase in axillary temperature and, if so, at what temperature the symptoms became disabling. Sixteen of 20 patients (80.0%) responded that they had such symptoms, which included worsening of general fatigue (n = 12, 75.0%), feelings that their brain did not work properly (n = 5, 31.3%), inability to move (n = 4, 25.0%), hot flashes/feeling of heat (n = 3, 18.8%), headache (n = 2, 12.5%), dizziness (n = 2, 12.5%) and anorexia (n = 1, 6.3%). The axillary temperatures at which patients felt worsening fatigue ranged from 37.0 °C to 37.4 °C in 7 of the 12 patients (58.3%) who experienced worsening fatigue. The patients also reported that the disabling symptoms, with the exception of headache, were not alleviated by antipyretics.

Conclusions
Many patients with FH reported worsening fatigue as a disabling symptom associated with increased axillary temperature; more than half of those patients experienced worsening fatigue in the temperature range of 37.0 °C to 37.4 °C. These findings suggest that the reasons patients with FH consider 37 °C disabling and seek medical treatment are that physical symptoms such as fatigue worsen at 37 °C, although this temperature is assumed by many physicians to be within the normal range or just above the normal range of axillary temperature, and that most hyperthermia-associated symptoms are not alleviated by antipyretic drugs.
Long-term trends in Alzheimer’s disease and other dementias deaths with high body mass index in China from 1990 to 2019, and projections up to 2042
Authors: Tao Mengjun , Guo Hao-Yang , Ji Xincan , Wang Wei , Yuan Hui , Peng Hui 
Published: March 2024

Abstract
Background
In China, the rising prevalence of high Body Mass Index (BMI) is linked to increasing health issues, including Alzheimer’s disease (AD). This study analyzes mortality trends related to AD and other dementias associated with high BMI from 1990 to 2019, considering age, period, and birth cohort effects, and forecasts future trends.

Methods
We analyzed mortality data for AD and other dementias linked to high BMI in Chinese residents from the Global Burden of Disease 2019 database. Using Joinpoint regression, we examined age-standardized mortality rate (ASMR) trends and calculated annual and average annual percentage changes (APC and AAPC). Age-period-cohort models provided deeper insights, with Bayesian models used to project future ASMR trends to 2042.

Results
From 1990 to 2019, the ASMR for AD and other dementias associated with high BMI in China showed an overall increasing trend. Females had a lower increase rate than males, yet their overall levels remained higher. Specifically, the ASMR for males increased by an average of 2.70% per year, peaking between 2006 and 2010, while for females, it increased by an average of 2.29% per year, also peaking in the same period. Age-period-cohort analysis revealed increasing mortality relative risk with age and period, but a decrease with birth cohort. Projections suggest a continued rise in ASMR by 2042, with rates for males and females expected to be 2.48/100,000 and 2.94/100,000, respectively.

Conclusion
The increasing mortality trend from AD and other dementias associated with high BMI highlights the urgent need for policy interventions focused on overweight prevention, particularly vital for addressing the health challenges in China’s aging population.
Paternal aging impacts expression and epigenetic markers as early as the first embryonic tissue lineage differentiation
Authors: Denomme Michelle M. , McCallie Blair R. , Haywood Mary E. , Parks Jason C. , Schoolcraft William B. , Katz-Jaffe Mandy G. 
Published: March 2024

Abstract
Background
Advanced paternal age (APA) is associated with adverse outcomes to offspring health, including increased risk for neurodevelopmental disorders. The aim of this study was to investigate the methylome and transcriptome of the first two early embryonic tissue lineages, the inner cell mass (ICM) and the trophectoderm (TE), from human blastocysts in association with paternal age and disease risk. High quality human blastocysts were donated with patient consent from donor oocyte IVF cycles from either APA (≥ 50 years) or young fathers. Blastocysts were mechanically separated into ICM and TE lineage samples for both methylome and transcriptome analyses.

Results
Significant differential methylation and transcription was observed concurrently in ICM and TE lineages of APA-derived blastocysts compared to those from young fathers. The methylome revealed significant enrichment for neuronal signaling pathways, as well as an association with neurodevelopmental disorders and imprinted genes, largely overlapping within both the ICM and TE lineages. Significant enrichment of neurodevelopmental signaling pathways was also observed for differentially expressed genes, but only in the ICM. In stark contrast, no significant signaling pathways or gene ontology terms were identified in the trophectoderm. Despite normal semen parameters in aged fathers, these significant molecular alterations can adversely contribute to downstream impacts on offspring health, in particular neurodevelopmental disorders like autism spectrum disorder and schizophrenia.

Conclusions
An increased risk for neurodevelopmental disorders is well described in children conceived by aged fathers. Using blastocysts derived from donor oocyte IVF cycles to strategically control for maternal age, our data reveals evidence of methylation dysregulation in both tissue lineages, as well as transcription dysregulation in neurodevelopmental signaling pathways associated with APA fathers. This data also reveals that embryos derived from APA fathers do not appear to be compromised for initial implantation potential with no significant pathway signaling disruption in trophectoderm transcription. Collectively, our work provides insights into the complex molecular mechanisms that occur upon paternal aging during the first lineage differentiation in the preimplantation embryo. Early expression and epigenetic markers of APA-derived preimplantation embryos highlight the susceptibility of the future fetus to adverse health outcomes.
Comparing the effects of various β-blockers on cardiovascular mortality in breast cancer patients
Authors: Tabassum Mantasha , Chikermane Soumya G. , Johnson Camille , Abdulkareem Noor M. , Wang Elisabeth M. , Johnson Michael L. , Trivedi Meghana V. 
Published: March 2024

Abstract
Background
Cardiovascular (CV) disease is a leading cause of death in breast cancer (BC) patients due to the increased age and treatments. While individual β-blockers have been investigated to manage CV complications, various β-blockers have not been compared for their effects on CV death in this population. We aimed to compare CV mortality in older BC patients taking one of the commonly used β-blockers.

Methods
This retrospective cohort study was conducted using the Surveillance, Epidemiology and End Results (SEER) - Medicare data (2010–2015). Patients of age 66 years or older at BC diagnosis receiving metoprolol, atenolol, or carvedilol monotherapy were included. The competing risk regression model was used to determine the risk of CV mortality in the three β-blocker groups. The multivariable model was adjusted for demographic and clinical covariates. The adjusted hazard ratio (HR) and 95% confidence intervals (CI) were reported for the risk of CV mortality.

Results
The study cohort included 6,540 patients of which 55% were metoprolol users, 30% were atenolol users, and 15% were carvedilol users. Metoprolol was associated with a 37% reduced risk of CV mortality (P = 0.03) compared to carvedilol after adjusting for the covariates (HR = 0.63; 95% CI 0.41–0.96). No significant difference in the risk of CV mortality between atenolol and carvedilol users was observed (HR = 0.74; 95% CI 0.44–1.22).

Conclusions
Our findings suggest that metoprolol is associated with a reduced risk of CV mortality in BC patients. Future studies are needed to confirm these findings and understand the mechanism of action.
Non-singular straight dislocations in anisotropic crystals
Authors: Lazar Markus , Po Giacomo 
Published: March 2024

AbstractA non-singular dislocation theory of straight dislocations in anisotropic crystals is derived using simplified anisotropic incompatible first strain gradient elasticity theory. Based on the non-singular theory of dislocations for anisotropic crystals, all dislocation key-formulas of straight dislocations are derived in generalized plane strain, for the first time. In this model, the singularity of the dislocation fields at the dislocation core is regularized owing to the nonlocal nature of strain gradient elasticity. The non-singular dislocation fields of straight dislocations are obtained in terms of two-dimensional anisotropic Green functions of simplified anisotropic strain gradient elasticity. All necessary Green functions, including the two-dimensional Green tensor of the twofold anisotropic Helmholtz-Navier operator and the two-dimensional $$\varvec{F}$$

F

-tensor of generalized plane strain, are derived as sum of the classical part and a gradient part in terms of Meijer G-functions. Among others, we calculate the regularization of the Barnett solution for the elastic distortion of straight dislocations in an anisotropic crystal. In the framework of simplified anisotropic first strain gradient elasticity, the necessary material parameters are computed for cubic materials including aluminum (Al), copper (Cu), iron (Fe) and tungsten (W) using a second nearest-neighbour modified embedded-atom-method interatomic potential. The elastic distortion and stress fields of screw and edge dislocations of $$\frac{1}{2} \langle 111\rangle$$

1
2

⟨
111
⟩

Burgers vector in bcc iron and bcc tungsten and screw and edge dislocations of $$\frac{1}{2} \langle 110\rangle$$

1
2

⟨
110
⟩

Burgers vector in fcc copper and fcc aluminum have been computed and presented in contour plots.
An unusual testicular mass: myeloid sarcoma as a rare extramedullary manifestation of acute myeloid leukemia
Authors: Dharshini R. Padma Priya , Peter S. Babu , Chengalvarayan G. , Kalpana S. 
Published: March 2024

Abstract
Background
We report an unusual testicular mass with small bowel and retroperitoneal lymph node deposit proven to be myeloid sarcoma after complete histopathological and hematological workup. Myeloid sarcoma (MS) usually involves lymph nodes and head and neck regions. Uncommon sites like testis and ovary are rarely involved and pose a diagnostic challenge. Extramedullary myeloid sarcoma is most commonly associated with hematological malignancies like acute myeloid leukemia and myelodysplastic syndromes. It can precede or co-occur with AML. Considering it as a differential diagnosis in atypical presentation of testicular tumor helps in early treatment.

Case presentation
We present a case of TMS with small bowel and retroperitoneal deposits presenting initially as intussusception and a vague scrotal pain. The patient underwent unilateral left radical inguinal orchidectomy. Surgical pathology revealed myeloid sarcoma of the testicle. And later jejunojejunostomy was done for small bowel deposit causing obstruction with retroperitoneal lymph node biopsy taken which revealed granulocytic sarcoma deposit. He developed peripheral blood involvement 4 weeks postoperatively, and bone marrow biopsy showed acute myeloid leukemia.

Conclusions
With very short median survival period of 7.5 months, high index of suspicion is required where multifocal lesions are observed in various sites as in our case.
Associations of Regional Body Fat With Risk of Cardiovascular Disease and Mortality Among Individuals With Type 2 Diabetes
Authors: Qiu Zixin , Lee Dong Hoon , Lu Qi , Li Rui , Zhu Kai , Li Lin , Li Ruyi , Pan An , Giovannucci Edward L , Liu Gang 
Published: March 2024

Abstract

Context
It is largely unknown whether regional fat accumulation is associated with risk of cardiovascular disease (CVD) and mortality among individuals with type 2 diabetes (T2D), who often exhibit changes in relative fat distribution and have increased CVD risk.

Objective
To prospectively examine the association between regional body fat and risk of CVD in individuals with T2D and to determine whether the associations are independentof traditional measures of obesity.

Methods
The main analysis included 21 472 participants with T2D from the UK Biobank. Regional body fat was measured by bioelectric impedance assessment. Cox proportional-hazards regression models were used to estimate hazard ratios (HRs) and 95% CIs.

Results
Over a median of 7.7 years of follow-up, 3976 CVD events occurred. After multivariable adjustment, upper and lower body fat were independently and oppositely associated with CVD risk among patients with T2D. Higher arm fat percentage was linearly associated with increased CVD risk (Pnonlinear &gt; .05), while higher trunk fat percentage was nonlinearly associated with increased CVD risk (Pnonlinear &lt; .05). In contrast, higher leg fat percentage was nonlinearly associated with lower CVD risk (Pnonlinear &lt; .05). When comparing extreme quartiles, the multivariable-adjusted HR (95% CI) of CVD was 0.72 (0.58-0.90) for leg fat percentage, 1.63 (1.29-2.05) for arm fat percentage, and 1.27 (1.06-1.52) for trunk fat percentage. Similar patterns of associations were observed for all-cause and CVD mortality. In addition, leg fat percentage, but not other regional fat percentage, was associated with CVD risk independently of traditional measures of obesity.

Conclusion
Among people with T2D, arm fat and trunk fat were positively, whereas leg fat was inversely, associated with the risk of CVD and mortality. These findings highlight the importance of considering both the amount and the location of body fat when assessing CVD and mortality risk among individuals with T2D.
“Gods Feast on Holy Smoke, Not Tear Gas!”
Authors: Guo Ting 
Published: March 2024

Abstract
This article highlights the neglected political participation of Daoism, Buddhism, and Chinese folk religions in Hong Kong in recent years, focusing on how local communities creatively engage with three deities in particular, namely Wong Tai Sin 黃大仙, Kwan Kung 關公, and Che Kung 車公. Building on C. K. Yang's classic theories of diffused religion, it demonstrates how grassroots religions are diffused with political activism in Hong Kong as an example of what the political scientist and anthropologist James C. Scott refers to as “infrapolitics.” These three iconic deities of diffused religions have most famously become protest symbols with creativity, humor, and satire, in contrast with a secular China as well as the official portrayal of the violence of the protest. The transformation of these local deities from tourist attractions to protest symbols epitomizes Hong Kong's emerging identity through the celebration of its own guardian gods and their divine protection. This creative diffusion of grassroots religions as infrapolitics is central to the protesting city's moral landscape and sense of belonging.
Expansion of the Subcutaneous Compartment by Umbilicus Resection for Intrathecal Pump Placement: The “Karagoz-Hacivat Technique”
Authors: Isler Cihan , Cerci Huseyin Mert , Baghaki Semih , Aydin Yekta Servet , Toklu Süreyya , Hanci Mehmet Murat 
Published: March 2024

BACKGROUND AND OBJECTIVES:
Intrathecal baclofen (ITB) for severe spasticity can encounter complications such as wound dehiscence and ulcers because of elevated intracompartmental pressure within the abdominal subcutaneous and subfascial pocket housing the pump. We propose an innovative technique to manage ITB wound ulcers.

METHODS:
Resecting the umbilicus create a more spacious and less tension-prone pocket for the ITB pump.

RESULTS:
Between 2015 and 2023, we implanted ITB pumps in 65 patients. Among them, 5 patients presented with skin ulcer or dehiscence underwent surgery using the novel technique. Postoperative follow-up revealed successful wound healing, with no further wound-related complications.

CONCLUSION:
The proposed technique provides effective and practical solution to wound and skin complications related to ITB pump. Moreover, it may serve as a viable preemptive strategy during the initial implantation of the ITB pump in selected patients.