bluuebunny/crossref_metadata_2025_split huggingface dataset:
Facing the challenge of hospitality: Ukrainian refugees and local policy in a less developed region
Authors: Źróbek-Różańska Alina , Zysk Elżbieta , Pawlewicz Katarzyna , Źróbek-Sokolnik Anna 
Published: April 2024

Motivation: Since the beginning of the war, Poland has welcomed more than 1.5 million Ukrainian refugees. This new reality has put pressure on local authorities, especially those managing less developed, poorer regions with less experience in receiving immigrants, as they faced the sudden urge to accommodate the needs of these new arrivals.Aim: This article aims to present the profile, needs, and potential of people who have found refuge in less developed areas (i.e., Warmia and Mazury). It helps to anticipate and understand Ukrainian migration — as the influx of refugees has long-term effects, requiring local authorities to take action, i.e., to ensure the availability of social services. Integrating thousands of refugees requires careful planning, developed infrastructure, and funds. It is also worth considering the benefits of the potential of new residents. Another purpose is to share objective knowledge on the effects of the ongoing war.Results: Through the research, it has been possible to obtain a great deal of information about people who found refuge in a less attractive area for migration. Profile of the immigrant was created, and the needs in terms of social infrastructure and the set of advantages that immigrants can offer on the labor market were described.
Making a difference: neurological support in the community
Authors: Kinnear Eleanor (Ellie) , Beales David , Paton Alan , Challice Sara 
Published: April 2024

Nearly 3 million people in the UK have a neurological condition; stroke, traumatic brain injury, Parkinson's disease, multiple sclerosis, brain tumour, motor neurone disease, among others – all affecting the person for the rest of their life. The NHS provides treatment at the onset of a condition but after that, there is a huge need for ongoing support. Research shows that those who are supported and know more about their condition are less likely to have to call on further in-hospital and GP care. There is enormous scope for improving the quality of life for those with neurological conditions. The right support—therapeutic and social—makes all the difference. The book, which this article is based on, shows how those with neurological conditions benefit from integrated ongoing support provided in the local community and self-help, and how lives can be improved. It explains good practice and encouraging methods in the support and treatment of those with life changing conditions.
Characterization of patients requiring inpatient hospital ethics consults- A single center study
Authors: Mahadevan Aditya , Azizi Armon , Dastur Cyrus , Stern-Nezer Sara , Nahmias Jeffry , Dayyani Farshid 
Published: April 2024

Introduction
Ethics consultations are often needed at difficult junctures of medical care. However, data on the nature of how patient characteristics, including race/ethnicity, language, and diagnosis, affect ethics consult outcomes are lacking.

Methods
We performed a retrospective cohort study of all patients who were seen by the Ethics Consult Service between 2017 and 2021 at a large tertiary academic center with the aim of determining whether patient demographic and clinical factors were associated with the timing of ethics consult requests and recommendations of the ethics team.

Results
We found that patients admitted for COVID-19 had significantly longer median times to consult from admission compared with other primary diagnoses (19 vs 8 days respectively, p = 0.015). Spanish-speaking patients had longer median times to consult from admission compared to English speaking patients (20 vs 7 days respectively, p = 0.008), indicating that language barriers may play a role in the timing of ethics consultation.

Conclusions
This study demonstrates the need to consider clinical and demographic features when planning and prioritizing ethics consultations at large institutions to enhance consult efficiency, resource utilization, and patient experience and autonomy.
Cost-consequence analysis of ambulatory clinic- and home-based multidrug-resistant tuberculosis management models in Eswatini
Authors: Peresu Ernest , De Graeve Diana , Heunis J. Christo , Kigozi N. Gladys 
Published: April 2024

Background
We compared the cost-consequence of a home-based multidrug-resistant tuberculosis (MDR-TB) model of care, based on task-shifting of directly observed therapy (DOT) and MDR-TB injection administration to lay health workers, to a routine clinic-based strategy within an established national TB programme in Eswatini.

Methods
Data on costs and effects of the two ambulatory models of MDR-TB care was collected using documentary data and interviews in the Lubombo and Shiselweni regions of Eswatini. Health system, patient and caregiver costs were assessed in 2014 in US$ using standard methods. Cost-consequence was calculated as the cost per patient successfully treated.

Results
In the clinic-based and home-based models of care, respectively, a total of 96 and 106 MDR-TB patients were enrolled in 2014, with treatment success rates of 67.8% and 82.1%. Health system costs per patient treated were slightly lower in the home-based strategy (US$19 598) compared to the clinic-based model (US$20 007). The largest costs in both models were for inpatient care, administration of DOT and injectable treatment, and drugs. Costs incurred by patients and caregivers were considerably higher in the clinic-based model of care due to the higher direct travel costs to the nearest clinic to receive DOT and injections daily. In total, MDR patients in the clinic-based strategy incurred average costs of US$670 compared to US$275 for MDR-TB patients in the home-based model. MDR-TB patients in the home-based programme, where DOT and injections was provided in their homes, only incurred out-of-pocket travel expenses for monthly outpatient treatment monitoring visits averaging US$100. The cost per successfully treated patient was US$31 106 and US$24 157 in the clinic-based and home-based models of care, respectively. The analysis showed that, in addition to the health benefits, direct and indirect costs for patients and their caregivers were lower in the home-based care model.

Conclusion
The home‐based strategy used less resources and generated substantial health and economic benefits, particularly for patients and their caregivers, and decision makers can consider this approach as an alternative to expand and optimise MDR-TB control in resource-limited settings. Further research to understand the appropriate mix of treatment support components that are most important for optimal clinical and public health outcomes in the ambulatory home-based model of MDR-TB care is necessary.
Exploring the Efficacy of Neuroplasticity-Driven Speech Therapy for Post-Stroke Aphasia Recovery: A Multimodal Intervention Approach
Authors: Karim Sarah 
Published: April 2024

Objective: This study investigated the efficacy of a multimodal speech therapy intervention informed by neuroplasticity principles in promoting post-stroke aphasia recovery.

Methods: A quasi-experimental design with 17 participants, using pre- and post-test assessments to compare the intervention –incorporating Constraint-Induced Aphasia Therapy (CIAT), Melodic Intonation Therapy (MIT), Script Training, and Cognitive-Communication Therapy (CCT)– to traditional speech therapy in individuals with aphasia.
The Boston Diagnostic Aphasia Examination (BDAE) and Mini-Mental State Examination (MMSE) assessed language and cognitive function, while the Functional Outcome Questionnaire for Aphasia (FOQ-A) and in-depth interviews evaluated functional communication and subjective experiences.

Results: The intervention group demonstrated significant improvements in expressive language (25% increase vs. 12% control), receptive language (20% vs. 14% control), language comprehension (18% vs. 8% control), and cognitive performance (15% vs. 9% control). Qualitative findings revealed enhanced communicative effectiveness, increased confidence in verbal interactions, and improved quality of life in the intervention group.

Conclusions: This multimodal, neuroplasticity-driven intervention improved language and cognitive function in individuals with post-stroke aphasia, demonstrating its potential as an effective rehabilitation strategy. Future research should focus on long-term efficacy, individual response variability, and intervention optimization.
Pengembangan Modul Matematika Berbasis STEM Terintegrasi Nilai-nilai Keislaman Pada Materi Segi empat dan Segitiga di Kelas VII
Authors: Salmariayah Salma , Fina Tri Wahyuni  
Published: April 2024

ABSTRAK
Permasalahan yang dihadapi oleh siswa di MTs NU Assalam Kudus salah satunya adalah pemanfaatan LKS sebagai bahan ajar satu-satunya dengan tampilan yang kurang menarik, tidak mengikuti perkembangan teknologi terkini, serta tidak ada pengintegrasian dengan nilai-nilai keislaman. Tujuan dari riset ini untuk memperoleh pengetahuan mengenai proses dan kelayakan dalam mengembangkan modul matematika berbasis STEM terintegrasi nilai-nilai keislaman. Model 4D adalah model penelitian dan pengembangan yang digunakan dalam riset ini dengan empat tahapan yaitu define, design, develop, dan disseminate. Subjek dalam penelitian pengembangan ini adalah 38 peserta didik kelas VII D MTs NU Assalam Kudus dengan lingkup skala kecil (terbatas). Instrumen pengumpulan data yang dipakai adalah lembar validasi modul dan lembar angket respon peserta didik.
Hasil penelitian pengembangan ini disimpulkan bahwa modul matematika berbasis STEM terintegrasi nilai-nilai keislaman sudah dinyatakan valid dan layak digunakan dalam pembelajaran. Kelayakan ini didasarkan pada uji validasi ahli materi , media, dan agama menggunakan uji validitas Gregory dengan hasil validitas konstruknya adalah 1 dan dikategorikan memiliki validitas sangat tinggi. Setelah para ahli menyatakan bahwa modul matematika memiliki validitas sangat tinggi, maka dilakukan uji coba produk dengan nilai skor rerata persentase yaitu 73,5% dan termasuk kategori “Layak” digunakan di lapangan.
Kata Kunci: Pengembangan, Modul Matematika, STEM, Integrasi Nilai-nilai Keislaman
KARAKTERISASI KEMAMPUAN PENALARAN MATEMATIS PADA MATERI POLA BILANGAN
Authors: Alamsyah Amirudin , Faradiba Surya Sari , Alifiani  
Published: April 2024

Tujuan dari penelitian ini adalah untuk mengeksplorasi kemampuan penalaran matematis materi pola bilangan pada peserta didik kelas VIII di SMP Negeri 3 Kepanjen. Metode pengumpulan data yang digunakan dalam penelitian ini adalah metode Tes, Observasi dan Wawancara. Hasil penelitian menunjukkan bahwa peserta didik dengan kategori tinggi, mampu memahami permasalahan yang diketahui dan ditanyakan secara lengkap, mengajukan dugaan dan memanipulasi matematika dengan benar, melakukan perencanaan dengan cara mensubtitusikan untuk menyelesaikan masalah, dan mampu memeriksa kembali penyelesaian dengan cara menuliskan kesimpulan dengan tepat. Peserta didik dengan kategori sedang, mampu memahami permasalahan dengan menulis dan menjelaskan apa yang diketahui dan ditanyakan secara lengkap dengan mengajukan dugaan dan mampu mensubtitusikan soal dalam matematika, tetapi hasilnya salah dan tidak lengkap serta tidak bisa memberikan kesimpulan dengan baik dan tepat. Peserta didik dengan kategori rendah, dikatakan kurang bisa menjelaskan apa yang harus dituliskan pada lembar jawaban, namun bisa menyelesaikan jawaban secara lengkap melalui pengajuan dugaan. Selain itu, peserta didik pada kategori ini bisa memberikan cara yang sesuai dengan melakukan subtitusi tetapi jawaban masih salah dan kurang, dan tidak mampu memberikan sebuah hasil yang disimpulkan dengan tepat dan tidak memeriksa kembali hasilnya.
Inhibition of pannexin‐1 does not restore electrolyte balance in precystic Pkd1 knockout mice
Authors: van Megen Wouter H. , van Houtert Teun J. , Bos Caro , Peters Dorien J. M. , de Baaij Jeroen H. F. , Hoenderop Joost G. J. 
Published: April 2024

AbstractMutations in PKD1 and PKD2 cause autosomal dominant polycystic kidney disease (ADPKD), which is characterized by the formation of fluid‐filled cysts in the kidney. In a subset of ADPKD patients, reduced blood calcium (Ca2+) and magnesium (Mg2+) concentrations are observed. As cystic fluid contains increased ATP concentrations and purinergic signaling reduces electrolyte reabsorption, we hypothesized that inhibiting ATP release could normalize blood Ca2+ and Mg2+ levels in ADPKD. Inducible kidney‐specific Pkd1 knockout mice (iKsp‐Pkd1−/−) exhibit hypocalcemia and hypomagnesemia in a precystic stage and show increased expression of the ATP‐release channel pannexin‐1. Therefore, we administered the pannexin‐1 inhibitor brilliant blue‐FCF (BB‐FCF) every other day from Day 3 to 28 post‐induction of Pkd1 gene inactivation. On Day 29, both serum Ca2+ and Mg2+ concentrations were reduced in iKsp‐Pkd1−/− mice, while urinary Ca2+ and Mg2+ excretion was similar between the genotypes. However, serum and urinary levels of Ca2+ and Mg2+ were unaltered by BB‐FCF treatment, regardless of genotype. BB‐FCF did significantly decrease gene expression of the ion channels Trpm6 and Trpv5 in both control and iKsp‐Pkd1−/− mice. Finally, no renoprotective effects of BB‐FCF treatment were observed in iKsp‐Pkd1−/− mice. Thus, administration of BB‐FCF failed to normalize serum Ca2+ and Mg2+ levels.
Embracing Change: IUPAC’s Opportunities Moving Forward
Authors: García-Martínez Javier 
Published: April 2024

Abstract

The year 2024 marks the beginning of important changes at IUPAC, the result of a journey that began in 2019 and crystallized in some of the most important decisions for IUPAC’s future in recent decades, adopted at our latest General Assembly in The Hague last August. In this column, I would like to talk about the many things we have accomplished together in recent years but most of all the future, about the many opportunities I see for IUPAC in the years ahead.
BOLD: Color from Test Tube to Textile
Authors: Drago Elisabeth Berry 
Published: April 2024

Abstract

Red can be the color of passion and danger, or luck and prosperity. Blue can be the shade of sadness—singing the blues—or a sign of tranquility and serenity. As the Russian painter Wassily Kandinsky once affirmed, in his 1911 treatise
Concerning the Spiritual in Art
, “Color is a power which directly influences the soul.” Color is also culture: we’ve colored our environments, clothes, and bodies for thousands of years, since early humans applied simple organic stains derived from the plants around them. The art and science of dyeing is an ancient one; today it’s an economic and commercial powerhouse. The arrival of the first synthetic dyes in the 1850s—discovered by happenstance from experiments with coal tar waste—brought us a rainbow of new possibilities for fashion and textiles, from color “fads” and trends to new means for self-expression. But synthetic color’s dark side lingers in polluted waterways. A new exhibit at the museum of the Science History Institute explores these complex legacies.
Bold: Color From Test Tube To Textile
takes visitors on a colorful 150-year journey through the history of synthetic dyes, examining the people and places who’ve shaped our modern understanding of color—from the laboratory to the factory floor, from the runway to retail, and beyond.
The Polish Criminal Police, the German Special Court in Lemberg, and the Prosecution of Poles for Giving Refuge to Jews, September 1943 to June 1944
Authors: Frydel Tomasz , Kloes Andrew 
Published: April 2024

Abstract
This source publication contains three categories of documents related to the Nazi German occupation of Poland, specifically the city of Lwów (Lemberg) in District Galicia of the General Government, which have been translated from German to English. The documents were selected for their relevance to ongoing debates and research questions evoked by the “third phase” of the Holocaust characterized by both widespread police searches for Jews and help offered by non-Jews to the fugitives, here set in the multi-ethnic context of Eastern Galicia between September 1943 and June 1944. Documents 1 to 4 are the German laws that formed the legal basis of decrees limiting Jewish residence and sanctioning punishment for their violation. Documents 5 to 7 are verdicts handed down by the Special Court in Lemberg (Sondergericht im Lemberg) on the basis of these decrees, in which the judges imposed the death penalty on the accused for giving refuge to Jews. Documents 8 to 11 are final reports regarding the arrests of Poles and Ukrainians, and the Jews whom they were sheltering, written by members of the Third Commissariat of the Lemberg Polish Criminal Police (PPK), which were sent to their supervisors in the German Criminal Police (Kripo).
Norwegian nurse educators’ self-rating of competencies: a nationwide cross-sectional web-survey
Authors: Gonzalez Marianne Thorsen , Bakken Linda Nilsen , Horntvedt May-Elin T. , Hofoss Dag , Salminen Leena 
Published: April 2024

Abstract

Background
Nurse educators’ competencies play a crucial role in the educational quality of nurses.

Objective
This study aimed to investigate how Norwegian nurse educators self-rated their competence domains, and how these competencies were associated background variables.

Methods
The study was designed as a cross-sectional web-survey, and n=154 participated and filled out the Evaluation of Requirements of Nurse Teachers (ERNT) instrument. Educators’ mean working experience was 12.9 years (SD 9.2); 86.3 % were permanently employed and 76.8 % had formal supervision training.

Results
The nurse educators rated their competence as good on all competence domains and single competence items, and ERNT total mean score was 4.62 (SD 0.28), with relationship with the students rated highest and personality factors rated lowest. The ERNT total mean score was significantly related to academic degree.

Conclusions
Educational leaders in nursing education are recommended to establish a mentoring and supporting team for their educators.
Crystal structure determination of NdB3.6O7
Authors: Teichtmeister Tobias A. , Bernhart Alexander Hugo , Huppertz Hubert 
Published: April 2024

Abstract
NdB3.6O7, orthorhombic, Pmn21 (no. 31), a = 10.4169(4) Å, b = 4.4175(2) Å, c = 4.2566(2) Å, V = 195.88(2) Å3, Z = 2, R
gt(F) = 0.0179, wR
ref(F
2) = 0.0405, T = 153(1) K.
The crystal structure of 6-methacryloylbenzo[d][1,3]dioxol-5-yl 4-nitrobenzenesulfonate, C17H13NO8S
Authors: Zhang Ailing , Hou Shu-Fen , Cao Shuhua , Sun Panpan , Sui Guoqing 
Published: April 2024

Abstract
C17H13NO8S, monoclinic, P21/c (no. 14), a = 17.7630(4) Å, b = 7.04725(16) Å, c = 13.7187(3) Å, β = 102.748(2)°, V = 1674.97(7) Å3, Z = 4, Rgt
(F) = 0.0557, wRref
(F
2) = 0.1652, T = 273 K.
Theoretical study of the effect of orientations and fibre volume on the thermal insulation capability of reinforced polymer composites
Authors: Shalwan Abdullah , Alajmi Abdalrahman , Yousif Belal 
Published: April 2024

Abstract
In industry, synthetic fibre reinforcements are popular due to their cost-effectiveness and lightweight nature. However, the non-reusability and non-degradability have raised environmental concerns and prompted scientists to explore more environmentally friendly alternatives. Natural fibres are being investigated as potential replacements to address these issues and promote sustainability. This study investigated the effect of fibre loading and orientation on the heat conductivity of polymer resins using a finite element-based numerical model developed in our previous research. The numerical analysis was conducted in ANSYS® modelling and simulation using glass and sisal fibres in combination with three distinct matrix materials (epoxy, polyester, and vinyl ester). Different orientations (parallel, perpendicular, 45°, and normal) and volume of fibre fractions (20–35%) were used for the analysis. The properties of the materials were incorporated into the ANSYS Engineering database, and the composite model was divided into five segments to analyse the heat transfer. The thermal boundary condition was implemented by keeping one side of the cylinder at 120°C. The results showed that the thermal conductivity of the composites decreased as the volume fraction of natural fibres increased. Epoxy-based composites exhibited better insulation performance than polyester and vinyl ester-based composites. This study demonstrated the potential of using natural fibres to improve the thermal insulation properties of composites.
The effect of anti-TNF drugs on the intestinal microbiota in patients with spondyloarthritis, rheumatoid arthritis, and inflammatory bowel diseases
Authors: Ciccia Francesco , Dussias Nikolas Konstantine , Gandolfo Saviana , Rizzello Fernando , Gionchetti Paolo 
Published: April 2024

Abstract
Spondyloarthritis (SpA), rheumatoid arthritis (RA), and inflammatory bowel diseases (IBD) are chronic inflammatory autoimmune diseases that are associated with alterations in the composition of the intestinal microbiota (i.e., dysbiosis). For SpA and RA, a gut-joint-enthesis axis is hypothesized and recent data suggests that dysbiosis may contribute directly to initiating and perpetuating joint and spine inflammation. Biologic drugs targeting tumor necrosis factor (TNF) are effective in treating these diseases and have been shown to partially restore the disrupted microbiome. Hence, drugs that affect both the intestinal and joint components of these diseases, such as anti-TNF drugs, may act on the intestinal microbiome. However, despite the remarkable efficacy of anti-TNF-α treatments, non-responders are frequent, and predictors of patient outcomes have not been identified. In this narrative review, we summarize recent research on the downstream effects of anti-TNF drugs on the intestinal microbiota in SpA, RA, and IBD. We also discuss whether these changes could have a role as predictive biomarkers of anti-TNF response.
Adalimumab in the management of psoriasis and psoriatic arthritis: Results from a Delphi investigation
Authors: Matucci-Cerinic Marco , Ciccia Francesco , Foti Rosario , Giunta Alessandro , Loconsole Francesco , Prignano Francesca , Scrivo Rossana , Girolomoni Giampiero 
Published: April 2024

Abstract

Background and Objectives
Psoriasis (PsO) and psoriatic arthritis (PsA) are often undertreated and require a multidisciplinary approach. In recent years, patent expiration has allowed the introduction of tumor necrosis factor inhibitor (anti-TNF) biosimilars, which have stimulated a significant increase in the use of biological therapies. This article reports the findings of a multidisciplinary approach to achieve a consensus on the use of adalimumab in patients with PsO or PsA.

Methods
A voting panel of 36 Italian dermatologists and rheumatologists were chosen by eight Italian clinicians (the Board), to provide a consensus on the real-world management of PsO and PsA with adalimumab using the Delphi Method, comprising three survey rounds. Twelve statements were defined by the Board and submitted to the panel (rating scale 1–7).

Results
Clinicians reached a wide consensus on the effectiveness (score 6–7: 67%) and long-term efficacy (6–7: 100%) of adalimumab in all clinical forms of PsO and PsA, including pediatric patients (6–7: 85%). Considering cost-effectiveness and safety, adalimumab is suggested as a first-line treatment in patients with enthesitis, predominant peripheral arthritis, axial involvement or associated inflammatory bowel disease (IBD) or uveitis. Adalimumab can be also considered after failure of etanercept (6–7: 94%).

Conclusion
Results from this Delphi study clearly show an overall consensus on the use of adalimumab in the management of PsO and PsA, particularly as first-choice for specific subpopulations (uveitis, IBD, hidradenitis suppurativa). Considering the cost-effectiveness of biosimilars within Italy, adalimumab may represent an effective and safe first-line treatment for patients with moderate-to-severe PsO or PsA, and a valid choice for switching after failure.