bluuebunny/crossref_metadata_2025_split huggingface dataset:
Food Values
Authors: Lusk Jayson L. , Briggeman Brian C. 
Published: July 2008

AbstractBecause of the potential malleability of stated and revealed preferences for new food technologies and attributes, this research sought to determine consumers' food value systems by utilizing recent advances in best‐worst scaling. Based on previous literature related to human values and food preferences, a list of eleven food values was compiled. Results reveal that on average the values of safety, nutrition, taste, and price were among the most important to consumers, whereas the values of fairness, tradition, and origin were among the least important; however, there was significant heterogeneity in the relative importance placed on food values. Results indicate that food values are significantly related to consumers' stated and revealed preferences for organic food.
Adjustment Costs and Immiserizing Growth in LDCs
Authors: Sarker Sanjib , Gilbert John , Oladi Reza 
Published: July 2008

AbstractUsing a general equilibrium model of a small developing economy, the authors demonstrate that the introduction of asymmetric adjustment costs makes the rate of urban employment respond to an exogenous shock in the aggregate capital endowment, raising the possibility of several counter‐intuitive immiserizing growth scenarios.
Efficacy and safety of felbamate in children under 4 years of age: a retrospective chart review
Authors: Grosso S. , Maria Cordelli D. , Coppola G. , Franzoni E. , Verrotti A. , Berardi R. , Balestri P. 
Published: July 2008

Background and purpose:  To review our experience of the efficacy and tolerability of felbamate in children younger than 4 years.Methods:  We used a retrospective chart review to identify 53 children with seizures who were younger than 4 years. Efficacy was evaluated based on the occurrence of responsiveness, defined as seizure frequency reduction of more than 50% for a minimum period of 4 months. Tolerability was based on parent‐reported side effects.Results:  Twenty‐two (41%) patients resulted to be responders and 31 (59%) did not. By univariate analysis, those achieving seizure remission were probably much older, to have a shorter history of epilepsy and a lower frequency of seizures before felbamate therapy. The number of antiepileptic drugs (AEDs) used before felbamate therapy was the only significant predictor of the duration of response to felbamate, with a longer responsiveness to the drug seen in those who were placed under fewer than three AEDs before felbamate compared with those who had taken more than three (median, 16 months vs. 7 months; P < 0.0084). Side effects occurred in 30% of the subjects, but these did not require discontinuation of the drug.Discussion:  Felbamate is an effective medication for a wide range of epilepsy syndromes in children younger than 4 years. Although caution is necessary when the drug is used in children, felbamate might represent a possible option for the treatment of epilepsy in this age group.
Case–control study of patients with essential tremor in Latvia
Authors: Inashkina I. , Radovica I. , Smeltere L. , Vitols E. , Jankevics E. 
Published: July 2008

Background:  Essential tremor (ET) is the most prevalent inherited movement disorder. ET has been mapped on chromosomes 2 and 3, but causative genes are not known.Methods:  We genotyped 16 microsatellite markers in a case–control cohort consisting of 104 patients and 116 controls.Results:  No significant difference between allele frequencies was found. The highest difference of frequencies was found in allele 171 of the marker D2S220 (OR 0.13, 95% CI 0.02–1.03, P = 0.05). In addition, we investigated the distribution of suspected disease gene DRD3 Ser9Gly polymorphism in the same patients and controls.Conclusion:  There was not a significant difference in genotypic distribution between disease group and control subjects (χ2 = 2.8, P = 0.25).
Morphometric evaluation of the repair of critical‐size defects using demineralized bovine bone and autogenous bone grafts in rat calvaria
Authors: Oliveira Rodrigo Cardoso de , Oliveira Fabio Henrique Gelonese de , Cestari Tânia Mary , Taga Rumio , Granjeiro José Mauro 
Published: July 2008

AbstractObjective: To evaluate the repair of critical‐size bone defects in rats treated with demineralized bovine bone (DBB) compared with autogenous bone (AB).Material and method: A bone defect of 8 mm in diameter was created in the calvaria of 50 Rattus norvegicus, treated either with DBB or AB. Sub‐groups of five rats of each group were killed at 7, 14, 21, 30 and 90 days post‐operatively, and the skulls were removed and processed histologically. Histological sections were stained with hematoxylin and eosin.Result: Histological analysis showed complete closure of the defects with new bone at 90 days in group AB, and substitution of the biomaterial by fibrotic connective tissue in the DBB group at 21 days. Morphometric analysis showed that DBB was rapidly absorbed at 14 days, with its volume density decreasing from 47%±0.8% at 7 days to 1.2%±0.41% at 14 days. Subsequently, volume densities of the connective tissue and neoformed bone increased from 51.1%±11.17% to 86.8%±7.92% and from 1.9%±1.13% to 12%±8.02%, respectively, for the same time interval. The volume density of AB particles did not change throughout the experimental periods, but the amount of new bone increased markedly between 7 and 90 days, from 4.5%±1.57% to 53.5%±6.42% (P<0.05).Conclusion: DBB did not provide complete repair of the defects, with significantly less new bone formation than in the AB group.
Analysis of association of clinical aspects and vitamin D receptor gene polymorphism with dental implant loss
Authors: Alvim‐Pereira Fabiano , Montes Claudia Cristina , Thomé Geninho , Olandoski Marcia , Trevilatto Paula Cristina 
Published: July 2008

AbstractOsseointegration failure is a complex, multifactorial trait shown to concentrate in some treated populations. There has been shown evidence for genetic contribution to dental implant loss. Genetic polymorphisms have been classically considered as genetic risk factors for several diseases and, more recently, for dental implant loss.Objectives: The purpose of this study was to access clinical factors related to failure process, and to investigate the relationship between a vitamin D receptor (VDR) polymorphism (rs731236, TaqI) and dental implant loss.Material and methods: Two hundred and seventeen unrelated patients, mean age 51.7±11.3 years, were divided into two groups: (i) control group (C), 137 individuals presenting at least one osseointegrated implant in function for 6 months or more and without any implant loss, and (ii) study group (S), 80 individuals presenting at least one implant loss. After DNA collection and purification, VDR TaqI polymorphism analysis was performed by polymerase chain reaction‐restriction fragment length polymorphisms (PCR‐RFLP). Differences between C and S, and between healthy (H; n=1232) and lost (L; n=135) implants were accessed.Results: Positive evidence of association has been detected between implant loss and the following variables: edentulism, implant position, primary stability, and implant length. Cox's regression model showed that primary stability, surgical technique and bone quantity were related to implant survival over time. No association between genotypes or alleles of VDR TaqI polymorphism and implant loss was found between the groups.Conclusion: It was observed that clinical variables, but not the study polymorphism, were associated with dental implant loss.
Clinical and histologic comparison of two different composite grafts for sinus augmentation: a pilot clinical trial
Authors: Galindo‐Moreno Pablo , Ávila Gustavo , Fernández‐Barbero Juan Emilio , Mesa Francisco , O'Valle‐Ravassa Francisco , Wang Hom‐Lay 
Published: July 2008

AbstractBackground and objectives: Sinus augmentation is a procedure used for augmenting insufficient bone height that is often observed in the maxillary posterior areas. Many different techniques as well as bone graft regimens have been suggested for performing this procedure. It was the goal of this study to compare, clinically and histologically, two different composite grafting regimens used for sinus augmentation.Material and methods: Five patients, needing a bilateral sinus augmentation to allow implant placement, were recruited for this study. Right sinuses were grafted with cortical bone (collected from overlying the sinus membrane) and bovine hydroxyapatite (HA), while the left side sinuses were grafted with overlying autologous bone plus a bioglass (BG) material. Bone core biopsies were taken at 6 months after sinus graft or at the time of implant insertion. A waiting period of 6 additional months was granted to allow healing, before prosthetic restoration and functional loading. The level of peri‐implant bone was evaluated 12 months after loading. A comparative histomorphometric analysis was conducted and a statistical analysis was performed.Results: All implants in both groups were functional after a 12‐month loading period. No bone loss was observed radiographically or clinically in both groups. Histologic analysis revealed that both composite grafts had a high biocompatibility. In the bovine HA‐containing group, minimal xenogenic graft absorption was noted. In contrast, BG group samples presented a high absorption rate with some remaining particles imbedded in new normal bone.Conclusions: Sinus augmentation using a combination of autogenous bone plus either bovine HA or BG is a predictable technique.
Cross‐linked and non‐cross‐linked collagen barrier membranes disintegrate following surgical exposure to the oral environment: a histological study in the cat
Authors: Tal Haim , Kozlovsky Avital , Artzi Zvi , Nemcovsky Carlos E. , Moses Ofer 
Published: July 2008

AbstractBackground: Early barrier membrane degradation may result in decreased bone formation in guided bone regeneration (GBR) procedures. The aim of this study was to evaluate the bio‐degradation of cross‐linked (CLM) and non‐cross‐linked (NCLM) collagen membranes experimentally exposed to the oral environment of study animals.Methods: In eight cats, 48 surgical procedures were performed, three along each side of the palate: 24 full‐thickness soft tissue perforations were made and 24 full‐thickness mini‐flaps were raised. CLM or NCLM discs were placed either under the perforations and peripheral mucosa and left exposed (experimental) or covered by the flaps (controls). The four treatment modalities were equally distributed among the eight animals. Block sections were retrieved at 7 and 28 days post‐operatively, providing histological specimens (6 each) at 7 and 28 days for each treatment modality.Results: Histological observation revealed that CLM and NCLM remained intact in the control sites during the 28 days. At 7 and 28 days, CLM appeared interrupted in three and two experimental sites, respectively, and were undetected in the remaining sites. NCLM were interrupted in two sites each at 7 and 28 days, and were undetected in the other sites. There was no statistical difference between control specimens and between CLM and NCLM of the different treatment modalities at 7 or 28 days.Conclusions: Both cross‐linked and non‐cross‐linked membranes were resistant to tissue degradation and maintained continuity throughout the study. However, none of the membranes was resistant to degradation when exposed to the oral environment.
Back‐scattered electron imaging and elemental microanalysis of retrieved bone tissue following maxillary sinus floor augmentation with calcium sulphate
Authors: Slater Nicola , Dasmah Amir , Sennerby Lars , Hallman Mats , Piattelli Adriano , Sammons Rachel 
Published: July 2008

AbstractObjectives: To investigate the presence and composition of residual bone graft substitute material in bone biopsies from the maxillary sinus of human subjects, following augmentation with calcium sulphate (CaS).Material and methods: Bone cores were harvested from the maxillary sinus of patients who had undergone a sinus lift procedure using CaS G170 granules 4 months after the initial surgery. Samples from seven patients, which contained residual biomaterial particles, were examined by field emission scanning electron microscopy and energy dispersive X‐ray spectroscopy was used to determine the composition of the remaining bone graft substitute material.Results: Residual graft material occurred in isolated areas surrounded by bone and consisted of individual particles up to 1 mm in length and smaller spherical granules. On the basis of 187 separate point analyses, the residual material was divided into three categories (A, B and C) consisting of: A, mainly CaS (S/P atomic% ratio ≥2.41); B, a heterogeneous mixture of CaS and calcium phosphate (S/P=0.11–2.4) and C, mainly calcium phosphate (S/P≤0.11; C), which had a mean Ca : P ratio of 1.63±0.2, consistent with Ca‐deficient hydroxyapatite. Linescans and elemental maps showed that type C material was present in areas which appeared dense and surrounded, or were adjacent to, more granular CaS‐containing material, and also occurred as spherical particles. The latter could be disintegrating calcium phosphate in the final stages of the resorption process.Conclusions: CaS resorption in the human maxillary sinus is accompanied by CaP precipitation which may contribute to its biocompatibility and rapid replacement by bone.
Evaluation of the marginal precision of one‐piece complete arch titanium frameworks fabricated using five different methods for implant‐supported restorations
Authors: Torsello Ferruccio , Di Torresanto Vincenzo Mirisola , Ercoli Carlo , Cordaro Luca 
Published: July 2008

AbstractObjective: The aim of the present work was to compare the marginal precision of titanium frameworks for a complete arch‐fixed prosthesis fabricated using five different methods.Methods: A prospective study was designed. Fifteen titanium frameworks for totally edentulous upper or lower jaws, each supported by five to nine implants, were assigned to five study groups, so as to have three frameworks in each group for each technique: (1) lost wax technique frameworks, (2) cast titanium sovrastructures laser welded to prefabricated titanium copings, (3) Procera® Implant Bridge, (4) Cresco Ti System™ and (5) CAM StructSURE® Precision Milled Bar. The microgap between the framework and the shoulders of implant analogues was measured on the master cast with a stereomicroscope at a magnification of 100 × at four different locations, yielding a total of 364 data points on 91 implants. Data were analyzed using an ANOVA and a Tukey post hoc test (P=<0.05).Results: The mean values for the microgap were 78 μm (SD±48) for lost wax technique frameworks, 33 μm (SD±19) for cast titanium sovrastructures laser welded to titanium copyings, 21 μm (SD±10) for the Procera® implant bridge, 18 μm (SD±8) for the Cresco Ti System™ and 27 μm (SD±15) for the CAM StructSURE®. The differences among the mean values were statistically significant (P<0.01 or P<0.05). The comparisons among groups 3, 4, and 5 and between groups 2 and 5 were not significant (P>0.05).Conclusion: The computer‐aided procedures analyzed in the present study were able to produce a precision‐fitting framework, with no significant differences among them and, at the same time, showed a greater precision compared with the traditional casting methods or with the use of prefabricated titanium copings. However, it should be noted that, even if group 2 frameworks were not as accurate as groups 3 and 4, cast titanium sovrastructures laser welded to prefabricated titanium copings showed significantly better marginal precision than the frameworks produced with the lost wax technique.
Maxillary sinus floor elevation using a tissue‐engineered bone complex with OsteoBone™ and bMSCs in rabbits
Authors: Sun X.‐Juan , Zhang Z.‐Yuan , Wang S.‐Yi , Gittens S. A. , Jiang X.‐Quan , Chou L. Lee 
Published: July 2008

AbstractObjectives: To evaluate the effects of maxillary sinus floor elevation by a tissue‐engineered bone complex with OsteoBone™ and bone marrow stromal cells (bMSCs) in rabbits.Material and methods: Autologous bMSCs from adult New Zealand rabbits were cultured and combined with OsteoBone™ at a concentration of 20 × 106 cells/ml in vitro. Twenty‐four animals were used and randomly allocated into groups. For each time point, 16 maxillary sinus floor elevation surgeries were made bilaterally in eight animals and randomly repaired by bMSCs/material (i.e. OsteoBone™), material, autogenous bone and blood clot (n=4 per group). A polychrome sequential fluorescent labeling was also performed post‐operatively. The animals were sacrificed 2, 4 and 8 weeks after the procedure and evaluated histologically as well as histomorphometrically.Results: New bone area significantly decreased from weeks 2 to 8 in the blood clot group, while bone area in the autologous bone reduced from weeks 4 to 8. In both groups, a significant amount of fatty tissue appeared at week 8. Accordingly, augmented height in both groups was also significantly decreased from weeks 2 to 8. The bone area in the material‐alone group as well as in the bMSCs/material group, on the other hand, increased over time. Significantly more newly formed bone area and mineralization was observed in the center of the raised space in the bMSCs/material group than in the material‐alone group. The augmented height was maintained in these two groups throughout the course of this study.Conclusion: These results suggest that OsteoBone™ can successfully be used as a bone graft substitute and that the combination of this material with bMSCs can effectively promote new bone formation in sinus elevation.
Incidence of bacterial and fungal infections in newly diagnosed acute myeloid leukaemia patients younger than 65 yr treated with induction regimens including fludarabine: retrospective analysis of 224 cases
Authors: Malagola Michele , Peli Annalisa , Damiani Daniela , Candoni Anna , Tiribelli Mario , Martinelli Giovanni , Piccaluga Pier Paolo , Paolini Stefania , De Rosa Francesco , Lauria Francesco , Bocchia Monica , Gobbi Marco , Pierri Ivana , Zaccaria Alfonso , Zuffa Eliana , Mazza Patrizio , Priccolo Giancarla , Gugliotta Luigi , Bonini Alessandro , Visani Giuseppe , Skert Cristina , Bergonzi Cesare , Roccaro Aldo Maria , Filì Carla , Fanin Renato , Baccarani Michele , Russo Domenico 
Published: July 2008

AbstractObjectives:  Infections are the major cause of morbidity and mortality in patients with acute myeloid leukaemia (AML). They primarily occur during the first course of induction chemotherapy and may increase the risk of leukaemia relapse, due to a significant delay in consolidation therapy. The intensification of induction chemotherapy and the use of non‐conventional drugs such as fludarabine are considered responsible for the increased risk of infections.Methods:  In this study, we retrospectively analysed the infections occurred in 224 newly diagnosed AML patients ≤65 yr, consecutively treated between 1997 and 2002 with an induction regimen including fludarabine, arabinosyl cytosine and idarubicin, with or without etoposide (FLAI/FLAIE), in the context of three multicentric prospective trials (AML97, AML99, AML02).Results:  During the induction phase, 146 (65%) patients experienced fever of undetermined origin (FUO), 30 (13%) and 47 (21%) patients had Gram‐negative and positive bacteremias, respectively, and 10 (4%) patients developed a probable/proven invasive fungal infection (IFI). The fatality rate for Gram‐negative, Gram‐positive bacteremias and probable/proven IFI was 10%, 8% and 60% respectively. During consolidation, 75 (35%) patients had FUO, 43 (20%) and 40 (19%) patients had Gram‐negative and positive bacteremias, respectively, and 5 (2%) patients developed a probable/proven IFI. The fatality rate for Gram‐negative, Gram‐positive bacteremias and probable/proven IFI was 14%, 5% and 80% respectively. Interestingly, the overall incidence of microbiologically documented infections during induction was 38% and the incidence of probable/proven IFIs during the induction/consolidation programme was 7%. No infections caused by viruses or opportunistic pathogens were observed neither during induction, nor during consolidation.Conclusions:  These data, although retrospectively collected, suggest that fludarabine‐based chemotherapy is not associated with an increased incidence of infections, in particular IFIs, compared to conventional regimens commonly used for AML induction.
Is International Prognostic Scoring System (IPSS) still standard in predicting prognosis in patients with myelodysplastic syndrome? External validation of the WHO Classification‐Based Prognostic Scoring System (WPSS) and comparison with IPSS
Authors: Park Min Jae , Kim Hee‐Jin , Kim Sun‐Hee , Kim Dong Hwan , Kim Seok Jin , Jang Jun Ho , Kim Kihyun , Kim Won Seog , Jung Chul Won 
Published: July 2008

AbstractBackground:  This study was undertaken to evaluate the prognostic value of the WHO Classification‐Based Prognostic Scoring System (WPSS) and to compare it with that of the International Prognostic Scoring System (IPSS).Patients and methods:  149 patients de novo diagnosed as having myelodysplastic syndrome between December 1994 and February 2007, were evaluated retrospectively.Results:  WPSS presented an excellent method for risk‐stratifying patients into five subgroups, with different risks of death and leukaemic evolution. On univariate analysis, three components of WPSS – cytogenetic risk, WHO category and transfusion dependency – had good correlations with overall survival (OS) and time to leukaemic evolution (TTL). However, one component of IPSS – number of peripheral cytopenias – did not correlate with OS or TTL. WPSS could distinguish the truly low‐risk patients (very low) who had an excellent long‐term survival with rare leukaemic evolution, while IPSS could not. These patients should be managed with clinical observation and delayed treatment strategies. Furthermore, on multivariate analysis for OS, WPSS was found to be an independent prognostic factor for survival along with age [P = 0.04; hazard ratio (HR) = 1.71; 95% confidence interval (CI) 1.02–2.85] and lactate dehydrogenase (LDH) (P = 0.002; HR = 2.47; 95% CI 1.41–4.31). On the other hand, the prognostic significance of IPSS was not confirmed.Conclusion:  These results suggest that the WPSS might be a more powerful predictor of prognosis than IPSS and that independent validation of several other, larger data sets should be necessary.
ORIGINAL ARTICLE: Genetic Predisposition to Idiopathic Recurrent Spontaneous Abortion: Contribution of Genetic Variations in IGF‐2 and H19 Imprinted Genes
Authors: Ostojić Saša , Pereza Nina , Volk Marija , Kapović Miljenko , Peterlin Borut 
Published: July 2008

Problem  Recurrent spontaneous abortion (RSA) is a common clinical problem with a complex etiology of genetic and non‐genetic causes, which remains to be fully determined. IGF‐2 stimulates trophoblast invasion, proliferation and maturation of placenta, while H19 RNA suppresses growth. As genomic imprinting plays a critical role in the development of placenta and embryo, our aim was to evaluate the possible role of variations in IGF‐2 and H19 imprinted genes as factors of predisposition for RSA.Method of study  A case–control study was conducted to determine the association between IGF‐2 and H19 gene polymorphisms and the susceptibility to RSA in 113 couples with RSA and 226 controls. PCR/RFLP were performed to analyze IGF‐2 ApaI and H19 HhaI polymorphisms.Results  We found a statistically significant difference in the genotype frequency distribution of IGF‐2 ApaI polymorphism between males from couples with RSA and healthy males (χ2(2) = 45.12; P < 0.0001). There were no differences in the genotype and allele distribution of H19 polymorphism frequencies, or for the IGF‐2 ApaI polymorphism between female groups.Conclusion  The presence of IGF‐2 ApaI polymorphism in partners of RSA women could affect IGF‐2 level of expression in placenta and embryo and represent a risk factor for RSA susceptibility.