bluuebunny/crossref_metadata_2025_split huggingface dataset:
High‐dose cyclophosphamide and adriamycin with DTIC maintenance for metastatic soft tissue sarcomas
Authors: Clamon Gerald , Sinkey Christine , Jochimsen Peter 
Published: February 2007

AbstractIntensive chemotherapy with high‐dose cyclophosphamide and adriamycin with DTIC maintenance was given to 12 patients with metastatic soft tissue sarcomas. A partial response rate of 25% was seen; this is no better than can be achieved with single‐agent therapy. Because of substantial toxicity without improved efficacy, the trial of high dose therapy was halted.
Treatment outcome of recurrent cervical cancer
Authors: Chung C. K. , Nahhas William A. , Stryker John A. , Mortel Rodrigue 
Published: February 2007

AbstractA total of 85 patients with recurrent cervical cancer were reviewed: 17 patients with recurrences were treated by radical surgery, 18 by radiotherapy, 29 by chemotherapy, and 21 cases received no further treatment. Survival was presented according to the site of recurrence and the mode of therapy. All patients were followed for a minimum of 24 months after recurrence.Of the total group, 14% are living without evidence of disease, 29% died of metastatic disease with no involvement in the pelvis, and 45% died of pelvic cancer. Overall, 22% were living more than 2 years, and only 2% lived over 5 years after recurrence.The NED (no evidence of disease) rate for radical surgery group was 47 and 44% for the radiotherapy group. There were no significant differences in median survival between the chemotherapy group and the notreatment group (6.8 versus 4.8 months). New chemotherapy agents and adjuvant systemic therapy are discussed.
Colorectal cancer in patients under 40 years of age
Authors: Lundy Joel , Welch John P. , Berman Martin 
Published: February 2007

AbstractA retrospective chart review was undertaken on all Hartford Hospital Tumor Registry patients under age 40 with a diagnosed adenocarcinoma of the colon or rectum between the years 1955 and 1980. Of the 45 patients who could be accurately staged by the Dukes classification, only about one‐third had disease localized to bowel. No unique histological pattern was observed. An excess of multiple primary tumors was observed (13%). Stage of disease at the time of presentation, rather than histology, was the most important prognostic factor in this study. Carcinoma of the rectum in our series had a 5‐year survival rate of 8%. This group of young patients should be managed with aggressive multimodal therapy.
Unusual tumours of the lung
Authors: Wright E. S. , Pike E. , Couves C. M. 
Published: February 2007

AbstractUnusual lung tumours are not simply pathological curiosities. They demonstrate features of major significance in diagnosis, treatment, and prognosis. Six of these tumours are discussed: (1) Carcinosarcoma is rarely found in the lung. The histogenis of the lesion is unclear and the prognosis is poor. (2) Only three cases of pleomorphic adenoma have previously been described. Differentiation from other “mixed tumours” of the lung is essential. (3) A rare case of bronchial adenoma producing ectopic ACTH is described. Early recognition of these polypeptide hormone‐secreting tumours is streessed. (4) Oat cell carcinoma with the myasthenic (Eaton‐Lambert) syndrome shows the clinical features which should permit early tumour diagnosis. The hazards of muscle relaxants must be recognized. (5) Prostatic carcinoma with endobronchial metastases is discussed. The importance of localization of the primary tumour is emphasized. (6) An example of double primary carcinoma is presented. The rarity of this finding may be related to the poor prognosis of patients with bronchogensis carcinoma.
Male breast carcinoma: An updated experience at a veterans administration hospital and review of the literature
Authors: Bavafa Shariar , Reyes Cesar V. , Choudhury Abdul M. 
Published: February 2007

AbstractTen cases of male breast carcinoma are reviewed. Male patients with breast cancer on the average are 10 years older than females, and they delay twice as long as females after noting a breast mass before seeking medical attention. Because of this patient's delay, male breast cancer tends to be more advanced at the time of diagnosis and initial therapy than female breast cancer.
Esophageal metastasis from a peripheral lung carcinoma masquerading as a primary esophageal tumor
Authors: Inoshita Tsuyoshi , Youngberg George A. , de Koos Paul Thur 
Published: February 2007

AbstractA 65‐year‐old man presented with progessive dysphagia, which proved to be the first clinical manifestation of a periperal lung carcinoma (secondary to a submucosal metatasis in the esophagus). The lung tumor, hidden by the diaphragm on chest x‐ray, was not suspected until a thoracotomy was done. Although dysphagia is known to be the first manifestation of bron‐chogenic carcinomas, such presentation in a case of a peripheral lung carcinoma has not been well described. This case is reported with a review of the literature for cases with dysphagia secondary to a metastatic tumor in the esophagus.
Sulindac for polyposis of the colon
Authors: Waddell William R. , Loughry Richard W. 
Published: February 2007

AbstractFour members of a Gardner's syndrome family had rectal and colon polyposis treated with nonsteroid anti‐inflammatory drugs. Three of these patients had had subtotal colectomy and ileoproctostomy and the residual polyps arose in the rectal mucosa. The polyps almost completely disappeared when sulindac was administered. Indomethacin therapy over the course of a preceding year was ineffective in one of these patients. One patient (case 4) had diffuse polyposis in an intact colon. After sulindac therapy for a year, only three small mucosal polyps could be identified by air contrast barium enema and colonoscopic examination. These observations confirm those of Pollard and Luckert [1,2] on rats with chemically induced polyposis of the intestinal tract.
Granular cell tumor of the bronchus coexisting with a bronchogenic adenocarcinoma: A case report
Authors: Gabriel Juan B. , Thomas Louys , Mendoza Concepcion B , Chauhan Prem M. 
Published: February 2007

AbstractA case of endobronchial granular cell tumor and an adenocarcinoma in the same lobe of the lung are presented. A review of the literature documents 2 cases where there was coexistence of a bronchogenic carcinoma and a granular cell tumor. The different theories regarding the origin of granular cell tumors are considered. The treatment of choice would be that indicated for the carcinoma irrespective of the granular cell tumor.
Combined modality treatment of pancreatic cancer: Implications for the surgeon
Authors: Metzger Urs F. , Kisner Daniel L. , Ghosh Bimal C. 
Published: February 2007

AbstractSince pancreatic cancer is still increasing and has a poor prognosis, there is great interest in improving treatment results by combined modality approaches. This paper considers the most appropriate studies to analyze the status of treatment and future implications for surgeons. With new radiation sources and more sophisticated treatment plans, intra‐ and post‐operative radiotherapy now has an established role in local tumor control. Combination chemotherapy has yielded response rates of 40–45% and improved chemotherapy will play a role in the treatment and perhaps in the prevention of disseminated disease. Although it seems likely that chemotherapy combined with newer radiotherapeutic technique could improve treatment results in advanced pancreatic cancer, treatment‐related and limiting toxicity still must be defined. There are suggestions that more surgeons become involved in the combined modality approach, as both radiotherapy and chemotherapy may be more valuable in primary management. The unsatisfactory results of surgical treatment imply the need for adjuvant treatment, which must be tested in randomized multicenter trials. Future efforts will require an interdisciplinary approach to this disease.
Cervical metastases from small bowel carcinoid tumors
Authors: Marks William H. , Strodel William E. , Lloyd Ricardo V. , Eckhauser Frederic E. , Thompson Norman W. , Vinik Aaron I. 
Published: February 2007

AbstractSmall bowel carcinoid tumors usually metastasize to regional lymph nodes and the liver but metastases to the neck are extremely rare. Over a ten‐year period 48 cases of small bowel carcinoid were diagnosed at our institution and of these, three cases (6%) were associated with neck metastases—one to the thyroid gland and two to cervical lymph nodes. The former patient and one of the latter patients had symptoms of the carcinoid syndrome. The other patient was asymptomatic and presented with a solitary neck mass. Urine levels of 5‐hydroxyindolacetic acid (5‐HIAA) were elevated in the two symptomatic patients but were undetectable in the asymptomatic patient. Extirpation of the involved cervical nodes and the primary small bowel lesion was performed in two patients. In addition, both patients have received chemotherapy with 5‐fluorouracil. One patient remains asymptomatic four years after diagnosis but the other patient continues to have five to six bowel movements per day nine months after operation. Small bowel resection was performed in the patient with a metastasis to the thyroid. This patient died of sepsis after a second operation for an intraabdominal abscess. The histological patterns of the primary tumor and the metastatic lesions were similar and the cells of the metastases contained argentaffin‐positive granules. We conclude that 1 an intraabdominal carcinoid tumor should be considered as the location of the primary tumor in patients who present with a neck mass containing metastatic carcinoid and 2 the prognosis for patients with extraabdominal metastases is similar to that for patients with intraabdominal disease only.
Hemangioma of the urinary bladder
Authors: Sarma Deba P. , Weiner Marshall 
Published: February 2007

AbstractA hemangioma of the urinary bladder occurring in a 66‐year‐old man is described. Although hemangioma is a common lesion in many parts of the body, it remains a very rare primary tumor in the bladder. Clinically the patient usually presents with recurrent hematuria, control of which may necessitate a segmental cystectomy.
Hepatic trisegmentectomy for metastatic colorectal cancer
Authors: Nims Thomas A. 
Published: February 2007

AbstractRadical Hepatic Resections For Metastatic Liver Disease Have Been Infrequently Done And Widely Criticized. Seven Patients Are Evaluated Who Had Trisegmentectomies Performed For Extensive Liver Metastases From Colorectal Primaries. There Was 1 Postoperative Death. Of The 6 Evaluable Patients, 4 (66%) Were Alive At 12 Months. Mean Survival Curently Exceeds 20 Months With The Longest Survivor Alive At 41 Months. Radical Hepatic Resections May Offer This Group Of “Hopeless” Patients Many Months Of Productive Life.
Hematoporphyrin derivative: Quantitative uptake in dimethylhydrazine‐induced murine colorectal carcinoma
Authors: Agrez M. V. , Wharen R. E. , Anderson R. E. , Laws E. R. , Ilstrup D. M. , Cortese D. A. , Shorter R. G. , Lieber M. M. 
Published: February 2007

AbstractThe selective affinity of hematoporphyrin derivative (HpD) for dimethyl‐hydrazine‐induced colorectal malignancies in mice was evaluated both visually and by a quantitative microfluorescent photometric technique. A significant corelation was found between higher concentrations of HpD in colon biopsies determined by microfluorescence spectroscopy and the presence of carcinoma cells in these biopsies as identified by histologic examination. Visual inspection of the gross fluorescence of tumor‐bearing colons in this experimental model, however, was not helpful in differentiating malignant from nonmalignant tissue. The implications of this study regarding the clinical application of HpD tumor fluorescence for the detection of colorectal carcinoma are discussed.
ABO (H) cell surface antigens in benign and malignant parotid neoplasms
Authors: Woltering Eugene A. , Tuttle Steven E. , James Arthur G. , Sharma Hari M. 
Published: February 2007

AbstractTwenty‐two inflammatory, benign, or malignant parotid lesions were studied by means of the specific red cell adherence test (SRCA), a modification of the Coombs' mixed cell agglutination reaction. In 22 normal parotid tissues the acinar structures were devoid of red cell agglutination, but it was present in ductal epithelium. Findings were similar in 2 cases of parotitis, 11 benign mixed tumors, and 1 malignant mixed tumor. All lacked red cell agglutination in areas of neoplastic change. Benign Warthin's tumors (4 cases) demonstrated antigenicity in the co‐lumnar epithelial component of the tumor, but lacked red cell agglutination in areas of the lymphoid component. One malignant Warthin's tumor showed agglutination in areas of normal columnar epithelium but not in areas of malignant dedifferentiation. Undifferentiated carcinoma (1 case) and adenoid cystic carcinoma (2 cases) did not possess detectable ABO (H) antigens in neoplastic areas of the gland. The absence of ABO antigens in normal acinar glands supports their suggested myoepithelial or mesenchymal derivation, as the absence of antigen in benign and malignant mixed tumors supports their proposed mesenchymal derivation. Ductular epithelium and the epithelial components of benign Warthin's tumors have ABO (H) antigens, while the loss of antigen in the epithelial portion of the malignant Warthin's tumor is characteristic of epithelial neoplastic dedifferentiation. Loss of antigen in adenoid cystic and undifferentiated carcinomas of the parotid supports the concept that antigen is absent in epithelially derived malignant neoplasms.
Treatment of advanced ovarian cancer with cisplatin, adriamycin, and cyclophosphamide: Effect of treatment and incidence of intracranial metastases
Authors: Budd G. Thomas , Webster Kenneth D. , Reimer Ronald R. , Martimbeau Pierre , Livingston Robert B. 
Published: February 2007

AbstractA retrospective analysis of 42 patients with stage III, IV, or recurrent epithelial ovarian carcinoma treated with monthly cisplatin, Adriamycin, and cyclophosphamide (PAC) was made. Of 36 patients with measurable disease, 18 (50%) achieved a clinical complete response (CR) and 12 (33%) achieved a partial response (PR) for an objective response rate of 83%. Six stage III patients remained without measurable disease after surgery and postoperative PAC and are included in the survival data. The median survival of all patients was 22 months (10 months for nonresponders), with a median duration of response of 15 months (19+ months for clinical complete responders). Of 16 patients who underwent second‐look laparotomy while in clinical CR, 8 were pathologically free of disease. Of these 8 surgically staged CRs, 2 have suffered CNS relapses, while the rest remain free of disease. One additional patient, who had been found to have only microscopic disease at the time of second‐look surgery, subsequently relapsed in the CNS, for a total of 3 patients with CNS relapse. We conclude that PAC is an effective regimen, but that prolonged survival of these patients may put them at greater risk for CNS relapse.
Proliferative potential of cells from normal human colon epithelium, adenomas, and carcinomas of the large bowel
Authors: Agrez M. V. , Barham S. S. , Tarara J. E. , Wolff B. G. , Reiman H. M. , Ilstrup D. M. , Lieber M. M. 
Published: February 2007

AbstractThe proliferative potential of nonmalignant and malignant cells obtained from the human large bowel was assessed with a soft agar culture colony‐forming technique and by flow cytometry to analyze cell cycle kinetics. No colony formation occurred with samples of normal human adult colon mucosa. The absence of colony formation in all but 1 of 24 evaluable colorectal adenomas suggested that malignancy of tissue in vivo is generally necessary for colony formation to occur in soft agar cultures. A high proliferative index (S + G2/M), as assessed by flow cytometry, was significantly associated with higher soft agar culture counts in a series of 25 colorectal carcinomas.
Verrucous carcinoma of the frontal sinus: A case report and review of the literature
Authors: Newman Anita N. , Colman Marc , Jayich Steven A. 
Published: February 2007

AbstractCarcinoma of the frontal sinus is rare. Treatment is controversial, and prognosis is poor, The etiology is unknown, although some risk factors for other paranasal sinus carcinomas have been identified.A 70‐year‐old male presented with proptosis and x‐ray findings consistent with a mucocele of the frontal sinus. At operation the patient was felt to have a cholesteatoma. Pathologic diagnosis was verrucous carcinoma of the frontal sinus. The case is discussed and the literature is reviewed.
Primary malignancy of the fallopian tube: A clinical review of 13 cases
Authors: Johnston George A. 
Published: February 2007

AbstractThirteen cases of primary fallopian tube cancer are presented from The Ohio State University Hospital. The majority of these tumors were diagnosed in the advanced stage of the disease with a considerable variety in histology for a small series.The Pap smear was quite meaningful in the diagnosis of malignancy in three of the cases; however, none of these cases was diagnosed preoperatively as a tubal primary cancer per se. A careful consideration of the history of pain, vaginal discharge, and pelvic mass is most important in making this diagnosis of tubal cancer preoperatively, along with a high index of clinical suspicion.In our experience, the stage of the disease was the single most important factor effecting patient survival. The mode of therapy appears to be a less important factor influencing survival. Patients treated with surgery and adjuvant chemotherapy had slightly better survival than did those patients in advanced stages treated by surgery and adjuvant radiation therapy.
Microinvasive squamous carcinoma of the vulva
Authors: Yoonessi Mahmood , Goodell Thomas , Satchidanand Sateesh , Fett Wolfgang , Solis Faustino 
Published: February 2007

AbstractThe clinico‐pathologic aspects of 15 cases of microinvasive squamous cell carcinoma of the vulva are analyzed and the literature on this subject is reviewed. Three patients in this group and 12.5% of the 279 reported cases, all with 5 mm or less depth of invasion, have had lymph node metastases and/or recurrences or have ultimately died of their disease. The prognostic value of lymphatic/vascular permeation, the degree of cellular anaplasia, the pattern as well as the depth of invasion, all have been alluded to, and the latter is popularized. It is noted, however, that the arbitrarily chosen 3 or 5 mm depth of invasion alone does not allow for consistent identification of individuals with a negligible risk for groin lymph node metastasis. There is indeed documentation of nodal metastases in 20 of 178 (11%) of the reported cases with 1–3.5 mm invasion. It is suggested that the level of invasion, as determined by Clark's classification, which provides a histologic reference point, may correlate better with the incidence of groin nodal metastasis, and its use may allow for individualized therapy and eventually aid in identifying cases of microinvasive carcinoma of the vulva that could safely be treated without lymphadenectomy.
The influence of intravenous hyperalimentation (IVH) on wound healing in tumor‐bearing rats
Authors: de Graaf Peter W. , Zwaveling Albert 
Published: February 2007

AbstractTwo studies were conducted to measure the metabolic influence of tumor growth in rats. Parameters for the metabolic state were wound‐healing qualities of colon and skin. Both early and later stages of tumor growth lowered wound healing qualities to a statistically significant degree. No anorexia or weight loss was found in this rat‐tumor model during the study period. Intravenous hyperalimentation (IVH; with proteins and carbohydrates) of tumor‐bearing rats stimulates tumor growth but at the same time restores wound‐healing qualities to control levels, both during early and later stages of tumor growth. It is suggested that tumor growth leads to an as yet not measurable disturbance of the metabolic equilibrium but that IVH can replenish the tumor‐bearing host and restore the metabolic equilibrium.
Permanent indwelling celestin tubes in malignant esophageal strictures
Authors: Lindholmer C. , Samuelsson S. , Theve N. O. 
Published: February 2007

AbstractEighteen patients with unresectable carcinoma of the esophagus were surgically intubated with the Celestin tube. Twelve patients (66.7%) had good palliation and relief of dysphagia. The operation mortality rate was 16.7%, which is in accordance with figures reported for endoscopic intubation of malignant strictures of the esophagus.
Tamoxifen response following no response to orchiectomy in metastatic male breast cancer: A case report
Authors: Hiluard Dennis A. , Wilbur David W. , Camacho Elber S. 
Published: February 2007

AbstractA male patient with advanced breast cancer had no response to orchiectomy but subsequently enjoyed a 17‐month partial response to tamoxifen 10 mg B.I.D. His tumor estrogen receptor (ER) protein was 555 fmol protein/ml cytosol. The potential role of ER determinations in the selection of therapy for advanced male breast cancer is discussed.
Multiple primary malignant neoplasms
Authors: Lee Shiong S. , Wasiljew Bohdan K. , Song Ki T. 
Published: February 2007

AbstractA 75‐year‐old man developed neurilemmoma of the left eighth cranial nerve, adenomatous polyp of the sigmoid colon, adenocarcinoma of the prostate, mixed cell type lymphoma of the right neck, and infiltrating ductal carcinoma of the right breast metachronously during a period of 38 years. The cancer of the right breast occurred 7 years after the long‐term stilbesterol treatment of prostatic carcinoma, which suggests a causal relationship between the hormonal therapy and development of breast carcinoma.
Simultaneous occurrence of adenocarcinoma and transitional cell carcinoma as two separate primary tumors in the bladder
Authors: Wiener Marshall , Sarma Deba P. , Weilbaecher Thomas G. 
Published: February 2007

AbstractWe report on a 56‐year‐old man who had two distinct and separate primary tumors of the bladder simultaneously: one mucin‐producing adenocarcinoma and the other a transitional cell carcinoma. Despite local extension of the adenocarcinoma beyond the bladder wall, surgical resection has resulted in a 6‐year recurrence‐free survival of the patient.
The effects of ascorbic acid and butylated hydroxyanisole in the chemoprevention of 1,2‐dimethylhydrazine‐induced large bowel neoplasms
Authors: Jones Frank E. , Komorowski Richard A. , Condon Robert E. 
Published: February 2007

AbstractHuman large bowel neoplasia seems to be caused by environmental carcinogens. The experimental carcinogen, 1,2‐dimethylhydrazine (DMH), must be oxidized in the body to have effect. The antioxidants, butylated hydroxyanisole (BHA) and ascorbic acid, were tested for efficacy in prevention of experimental large bowel neoplasia.Carcinogenesis was induced in female CF‐1 mice by administering DMH, 20 mg/kg, sq for 24 weekly doses. Test animals received varying doses of ascorbic acid, BHA, or both agents together. Animals were sacrificed when moribund or at 35 weeks. All colons were totally embedded and analyzed histologically.Ascorbic acid demonstrated no effects on incidence or density of large bowel tumors. Ascorbic acid did increase the ratio of adenomas to adenocarcinomas. BHA decreased the incidence and density of large bowel tumors. The lowest incidence was obtained in the group receiving both agents combined.It is concluded that BHA is effective in the chemoprevention of DMH‐induced large bowel neoplasms. Ascorbic acid demonstrates only modest effect. The greatest effect on tumor incidence is seen when ascorbic acid and BHA are administered together.