bluuebunny/crossref_metadata_2025_split huggingface dataset:
Field Validation of a Universally Applicable Condition-Based Maintenance System for Mud Pumps
Authors: Yoon Dongyoung , Ashok Pradeepkumar , van Oort Eric , Annaiyappa Pradeep , Abe Shungo , Ebitani Akira 
Published: April 2024

Summary
Although mud pumps are considered to be critical rig equipment, their health monitoring currently still relies on infrequent human observation and monitoring. This approach often fails to detect pump damage at an early stage, resulting in nonproductive time (NPT) and increased well construction costs when initial damage progresses and pumps go down unexpectedly and catastrophically. Automated approaches to condition-based maintenance (CBM) of mud pumps to date have failed due to the lack of a generalized solution applicable to any pump type and/or operating conditions.
This paper presents a field-validated universally applicable solution to mud pump CBM. The system uses a sensor package that includes acoustic emission sensors and accelerometers in combination with anomaly detection deep learning data analysis to pinpoint any abnormal behavior of the pump and its components. The deep learning models are trained with undamaged normal state data only, and a damage score characterizing the extent of damage to the mud pump is calculated to identify the earliest signs of damage. The system can then generate alerts to notify the rig crew of the damage level of key mud pump components, prompting proactive maintenance actions.
Field tests were conducted while drilling an unconventional shale well in west Texas, USA, and a geothermal well in Japan (i.e., two very different drilling operations) to verify the feasibility and general applicability of the developed pump CBM solution. Sensors were attached to pump modules, and data were collected and analyzed using the deep learning models during drilling operations. During the field tests, different hyperparameters and features were compared to select the most effective ones for identifying damage while at the same time delivering low false positive rates (i.e., false alarms during normal state pump operation). The system required only several hours of normal state data for training with no prior pump information. Moreover, it correctly identified the degradation of the pump, swabs, and valves and produced early alerts several hours (in the range of 0.5–17 hours) before actual pump maintenance action was taken by the rig crew.
This generally applicable pump CBM system eliminates the environmental, health, and safety concerns that can occur during human-based observations of mud pump health and avoids unnecessary NPT associated with catastrophic pump failures. The final version of this system will be a fully self-contained magnetically attachable box containing sensors and a processor, generating simple indicators for recommending proactive pump maintenance tasks when needed.
Inhibition Mechanism of Bionic Drainage Hole on Cavitation Flow in the Regulating Valve
Authors: He Jie , Zhang Yujia , Liu Weiwei , Liu Xiumei , Li Beibei 
Published: April 2024

Abstract

A valve seat structure with some bionic drainage of the regulating valve was designed which is inspired by the cuttlefish. The development and collapse of cavitation flow in the valve with this bionic valve seat was investigated with numerical simulation, experimental measurement and theoretical analysis. The influence of bionic drainage valve seat on the internal cavitation development and the distribution of three-dimensional cavitation morphology was also fully discussed. The results show that the bionic drainage hole structure destroyed the distribution law of the cavitation ring in the flow channel, and accelerated the collapse of the cavitation flow which mainly concentrates on the inner surface of the valve seat. Furthermore, the bionic drainage hole structure causes the vortex structure to break into smaller vortices during the cavitation collapse stage under the shear effect, so the cavitation bubble is dissipated in the form of smaller vortex breaking finally. The results provide a significant reference for optimum structural design of the regulating valve in the coal liquefaction project.
SUPPURATIVE THROMBOPHLEBITIS OF GREAT SAPHENOUS VEIN AFTER ENDOVENOUS LASER ABLATION - CASE REPORT
Authors: Matic Predrag , Babic Aleksandar , Tanaskovic Slobodan , Babic Srdjan , Gajin Predrag , Pesic Slobodan , Ilijevski Nenad 
Published: April 2024

Abstract

Background
Endovenous laser ablation (EVLA) is a minimally invasive technique used to treat superficial venous reflux. The technique proved its safety and efficacy and became the standard of care for patients with chronic venous disease with lower rates of complications compared to open surgery.
Case report
We present a 68-year-old female with C5 stage of chronic vein insufficiency who underwent endovenous laser ablation of the great saphenous vein. On the fifth day, she developed fever and pain, tenderness, and redness on the medial side of the treated upper leg with fluctuations in some places. Urgent incisions and radical debridement with extensive drainage were made. After intensive daily local wound treatment and antibiotic therapy signs and symptoms resolved and she was fully ambulatory with satisfactory postoperative findings.
Conclusion
We want to point out that aggressive surgical treatment is the main goal in the treatment of patients with suppurative thrombophlebitis, and, antibiotic therapy results in complete healing and resolution of this rare, but life-treating complication.
First in vivo images of the human brain revealed with the Iseult 11.7T MRI scanner
Authors: Boulant Nicolas , Mauconduit Franck , Gras Vincent , Amadon Alexis , Ster Caroline Le , Luong Michel , Massire Aurélien , Pallier Christophe , Sabatier Laure , Vignaud Alexandre , Bottlander Michel , Bihan Denis Le 
Published: April 2024

Abstract

The understanding of the human brain is one of the main scientific challenges of the 21st century. In this context, in the early 2000s the French Atomic Energy Commission (CEA) launched a program to conceive and build the first human MRI scanner operating at 11.7T. More than a decade of developments followed to deliver the magnet while six more years were necessary to complete the commissioning and finally obtain approval from the regulatory agencies to acquire the first ever human brain images in vivo at such magnetic field. We deployed parallel transmission tools to mitigate the radiofrequency field inhomogeneity problem and tame the specific absorption rate. To assure the safety of human imaging at such high field strength, we performed physiological, vestibular, behavioral and genotoxicity measurements on the volunteers. The data shows no evidence of adverse effects. The unprecedented field strength combined with the acquisition techniques deployed yield T2 and T2*-weighted images reaching mesoscale resolutions within short acquisition times and with a high signal and contrast to noise ratio.
Visible light Induced Photocatalytic Activity of Polypyrrole Decorated Zinc Ferrite Green Nanohybrids Against Cetirizine Hydrochloride Degradation
Authors: Gaffar shayista , Aazam elham S , riaz ufana 
Published: April 2024

Abstract

The present work reports photocatalytic degradation of cetirizine hydrochloride (CTZ-HCl) utilizing polypyrrole (PPy) nanohybrids with ZnFe2O4 (ZnFe) nanoparticles. The synthesized materials were characterized using UV-Visible spectroscopy, X-ray diffraction (XRD), fourier transform infrared spectroscopy (FT-IR), Photoluminescence (PL) spectroscopy, BET and scanning electron microscopy (SEM) techniques. IR and XRD analysis confirmed the formation of ZnFe/PPy nanohybrids. UV reflectance studies revealed that the band gap was found to decrease with increase in the loading of PPy and Kubelka -Munk plots confirmed the bandgap values to be 2.03 eV for ZnFe, 1.94 eV for 1% PPy/ZnFe, 1.66 eV for 3% PPy/ZnFe and 1.38 eV for 5% PPy/ZnFe. The photocatalytic performance against CTZ-HCl degradation was performed under visible light irradiation for 60 min. The effect of catalyst dosage and the effect of drug concentration were investigated to confirm degradation behavior of the PPy/ZnFe photocatalysts. The degradation followed the pseudo first order kinetics model. Maximum photocatalytic degradation was observed to be 98% within 60 minutes using 5% PPy/ZnFe as the photocatalyst. The recyclability tests revealed that the 5% PPy/ZnFe photocatalyst was reusable up to 4 cycles. Radical scavenging studies confirmed the generation of ●OH radicals that were responsible for the drug degradation. The degraded fragments were analyzed using LCMS technique and the tentative mechanism of degradation was proposed.
Fe(III) complexes with prolonged luminescence lifetimes and symmetry-breaking charge separation
Authors: Campagna Sebastiano , Genovese Salvatore , Cancelliere Ambra , Arrigo Antonino , Puntoriero Fausto 
Published: April 2024

Abstract
Iron(III) complexes with long-lived luminescence in fluid solution at room temperature (up to 6.5 ns, significantly longer than benchmark compounds) have been prepared, by taking advantage of the excited-state equilibration approach, for the first time applied to earth-abundant, iron(III) compounds. Pyrene subunits have been covalently-linked by methylene linkage to [Fe(phtmeimb)2]+ (1; phtmeimb is {phenyl[tris(3-methylimidazol-1-ylidene)]borate}−), so obtaining complex 3, and have been used to synthesize [Fe(pytmeimb)2]+ (2; pytmeimb is {2-pyrene[tris(3-methylimidazol-1-ylidene)]borate}−). In 2 and 3, the ligand-to-metal charge transfer (2LMCT) state decays by energy transfer to closely-lying p-p* pyrene triplets. Equilibrated states are so formed, resulting in 2LMCT emission from the Fe(III) subunit, in which pyrene triplets serve as long-lived excited-state reservoirs. In 2, symmetry-breaking charge separation in dilute fluid solution at room temperature also occurs.
Stimulatory effect of Phyllanthus amarus extract on growth performance, haemato-biochemical, anti-oxidative status and immune response of African catfish, Clarias gariepinus
Authors: Adeniyi Olarinke Victoria , Alade Adijat Omowunmi , Tijani Gafar Hammed 
Published: April 2024

Abstract
This study investigated the antibacterial activity of Phyllanthus amarus extracts and its influence on the growth, physiological and immune status of Clarias gariepinus fingerlings. The fish were fed diets containing 0.0 (control), 0.5, 1.0, 1.5 or 2.0g P. amarus extract (PAE)/kg basal diet to apparent satiation for 84 days. Thereafter, blood samples were collected from the fish and used for haematological and biochemical analyses. After the 84-day feeding, the fish were challenged with Aeromonas hydrophila by intraperitoneal injection, observed for survival, and immune response parameters were measured. Data were analyzed using one-way analysis of variance at P < 0.05. Results showed significant antibacterial activity of P. amarus methanol extract against A. hydrophila and its application at 0.5 -1.5g PAE significantly promoted weight gain and specific growth rate, with the highest at 1.0g, while the feed conversion ratio reduced significantly at these levels, compared to the fish fed the control diets. Haematocrit, haemoglobin and lymphocytes were enhanced at 0.5-1.5g PAE. All fish fed PAE-based diets had lower concentration of serum liver enzymes, with the least in fish fed 1.0-1.5g PAE diets, while the values of creatinine, glucose and total bilirubin did not differ among the treatments. Glutathione peroxidase and glutathione‐S‐transferase activities increased in all PAE-fortified treatments. Lysozyme, phagocytic and respiratory burst activities also increased in the challenged fish fed PAE diets. Post-challenge survival was highest at 1.0g PAE. Therefore, inclusion of 1.0g Phyllanthus amarus extract is recommended as dietary supplement for Clarias gariepinus.
Why does it take so long? The reasons behind Drug Resistant -Tuberculosis (DR-TB) treatment delay in Uganda
Authors: Nabukenya Diana Kasozi , Lwanga Charles , Asiimwe JohnBosco , Luzze Henry 
Published: April 2024

Abstract

Background
Tuberculosis (TB) persists globally despite effective medications, with drug-resistant strains complicating the situation. Challenges like patient adherence, lengthy treatment and delayed diagnoses contribute to treatment failures, especially in drug-resistant TB patients. The aim of the study was to investigate the socio-demographic, clinical, and structural factors associated with the timing of treatment initiation following DR-TB diagnosis among patients enrolled on DR-TB treatment in Uganda.
Method
Data from the Uganda National TB/Leprosy Program's national case registration database was used, with a sample size of 2,166 DR-TB patients, who completed treatment within a two-year follow-up period. Kaplan Meier survival curves, decrement life-tables and the discrete time-to-event analysis with logistic regression were used to examine the relationship between socio-demographic, clinical, and structural factors, and the timing of DR-TB treatment initiation following diagnosis.
Results
About fifty-seven percent of DR-TB patients experienced delays beyond the acceptable 7 days in treatment initiation, with an overall median time delay of 10 days. Patients with a previous treatment history of Lost to follow-up (Defaulter) and those in the failure category were less likely to initiate DR-TB treatment, whereas those in the ‘relapse category’, were more likely to initiate DR-TB treatment compared to the new DR-TB patients.
Conclusion
Thus, healthcare professionals in TB clinics need to be vigilant about DR-TB patients with previous treatment history and those in the failure category. In addition, future studies should endeavor to explore further the linkage between the sex of the patient, age of the patient, patient's HIV status, patient on ART & CPT, disease class, mode of treatment, and treatment initiation following diagnosis.
Anti-Phytomonas activity of the lyophilized residues obtained from the distillation of Lantana camara L. essential oil
Authors: Soares Caroline Alves , Santos Tamíris Aparecida de Carvalho , Nascimento Luís Fernando de Andrade , de Jesus Raphael Amancio , Blank Arie Fitzgerald , Scher Ricardo , Moraes Valéria Regina de Souza , Arrigoni-Blank Maria de Fátima , Fernandes Roberta Pereira Miranda 
Published: April 2024

Abstract

On an industrial scale, the residues accumulated in essential oil distilleries can be compared to the volume of residues produced in a textile industry. Although these residues are discarded, they possess molecules with diverse biological activities, including their application in phytopathogen control. In this study, the chemical profile of the residue from the hydrodistillation of Lantana camara L. leaves was determined using High-Performance Liquid Chromatography (HPLC). Additionally, the effect of the residue on cells was assessed by determining plasma membrane integrity, levels of reactive oxygen species (ROS) production, and mitochondrial potential depolarization. The viability and cell density of Phytomonas serpens parasites significantly decreased after treatment with increasing concentrations of the lyophilized residue. RL038, the lyophilized residue from accession LAC-038, reduced cell viability by an average of 61.36%. ROS levels increased by approximately 2x and 3x at RL038 concentrations of 120 µg/mL and 180 µg/mL, respectively. It was observed that the same concentrations modified mitochondrial potential, reducing fluorescence by 44.6% and 46.8%, respectively. Analytical liquid chromatography of RL038 revealed the presence of 17 peaks subsequently classified as phenolic acids and flavonoids. RL038 from the hydrodistillation of Lantana camara L. leaves is a source of biologically active compounds with antiprotozoal potential.
Digital image enhancement using Deep learning algorithm in 3D heads-up vitreoretinal surgery
Authors: Hwang Sung Ha , Cho Jae Bok , Kim Young Jae , Nam Dong Heun 
Published: April 2024

Abstract
This study aims to predict the optimal imaging parameters using a deep learning algorithm in 3D heads-up vitreoretinal surgery and assess its effectiveness on improving the vitreoretinal surface visibility during surgery. To develop the deep learning algorithm, we utilized 212 manually-optimized still images extracted from epiretinal membrane (ERM) surgical videos. These images were applied to a two-stage Generative Adversarial Network (GAN) and Convolutional Neural Network (CNN) architecture. The algorithm’s performance was evaluated based on the peak signal-to-noise ratio (PSNR) and structural similarity index map (SSIM), and the degree of surgical image enhancement by the algorithm was evaluated based on sharpness, brightness, and contrast values. A survey was conducted to evaluate the intraoperative suitability of optimized images. For an in-vitro experiment, 121 anonymized high-resolution ERM fundus images were optimized using a 3D display based on the algorithm. The PSNR and SSIM values are 34.59 ± 5.34 and 0.88 ± 0.08, respectively. The algorithm enhances the sharpness, brightness and contrast values of the surgical images. In the in-vitro experiment, both the ERM size and color contrast ratio increased significantly in the optimized fundus images. Both surgical and fundus images are digitally enhanced using a deep learning algorithm. Digital image enhancement using this algorithm can be potentially applied to 3D heads-up vitreoretinal surgeries.
Severe water deficit strongly impacts physiological and morphoanatomical traits of soybean cultivar during its vegetative stage
Authors: Sobrinho Mauriana da Rocha , Costa Niedja Bezerra , Santos Diego Pereira , Batista Diego Silva , Figueiredo Fábio Afonso Mazzei Moura de Assis , Felipe Sérgio Heitor Sousa , Junior Francisco Eduardo Aragão Catunda , de Andrade Jailma Ribeiro , Júnior Sebastião de Oliveira Maia , Corrêa Thais Roseli , Catunda Paulo Henrique Aragão , Reis Fabrício de Oliveira , Ferraz Tiago Massi 
Published: April 2024

Abstract

Several studies have investigated soybean response to drought, revealing significant changes in different physiological and anatomical traits. Investigating how plants respond to regulated deficit can help optimize water use efficiency and shed light on their tolerance and sensitivity to water stress at different phenological stages. Thus, this study aimed to assess the effect of water stress during the vegetative stages on the morphophysiological and water status characteristics of soybean cultivar. The experiment was conducted in a greenhouse at the State University of Maranhão. A completely randomized design with four irrigation levels: 100% field capacity (FC) (control), 75% FC, 50% FC, and 25% FC, and 20 replicates were used. Growth variables, physiological parameters, water-related parameters, and root, stem, and leaf anatomy were evaluated. Interaction was observed between water levels and assessment times for plant height and stem diameter growth rates. There was a significant reduction in gas exchange over time, with the greatest decline at 81 days after planting (DAP). The 25% FC treatment had the most pronounced effect on the photosynthetic CO2 assimilation (A), stomatal conductance (gs), transpiration (E), and carboxylation efficiency (CE), with reductions of 55, 72, 53, and 60%, respectively, compared to the control, at 80 DAP. Anatomical analysis revealed adaptations in the 25% FC treatment, characterized by increased stem sclerenchyma thickness and smaller root xylem vessel diameter. Plants in the 75% FC treatment showed similar responses to the control, demonstrating that this water regime did not compromise the growth and development of BRS Tracajá soybean plants.
Phosphorylation-Driven Epichaperome Assembly: A Critical Regulator of Cellular Adaptability and Proliferation
Authors: Chiosis Gabriela , McNutt Seth , Roychowdhury Tanaya , Pasala Chiranjeevi , Nguyen Hieu , Thorton Daniel , Sharma Sahil , Boticelli Luke , Digwal Chander , Joshi Suhasini , Yang Nan , panchal palak , Chakrabarty Souparna , Bay Sadik , Markov Vladimir , Kwong Charlene , Lisanti Jeanine , Chung Sun Young , Ginsberg Stephen , Yan Pengrong , de Stanchina Elisa , Corben Adriana , Modi Shanu , Alpaugh Mary , Colombo Giorgio , Erdjument-Bromage Hediye , Neubert Thomas , Chalkley Robert , Baker Peter , Burlingame Alma , Rodina Anna , Chu Feixia 
Published: April 2024

Abstract

The intricate protein-chaperone network is vital for cellular function. Recent discoveries have unveiled the existence of specialized chaperone complexes called epichaperomes, protein assemblies orchestrating the reconfiguration of protein-protein interaction networks, enhancing cellular adaptability and proliferation. This study delves into the structural and regulatory aspects of epichaperomes, with a particular emphasis on the significance of post-translational modifications in shaping their formation and function. A central finding of this investigation is the identification of specific PTMs on HSP90, particularly at residues Ser226 and Ser255 situated within an intrinsically disordered region, as critical determinants in epichaperome assembly. Our data demonstrate that the phosphorylation of these serine residues enhances HSP90's interaction with other chaperones and co-chaperones, creating a microenvironment conducive to epichaperome formation. Furthermore, this study establishes a direct link between epichaperome function and cellular physiology, especially in contexts where robust proliferation and adaptive behavior are essential, such as cancer and stem cell maintenance. These findings not only provide mechanistic insights but also hold promise for the development of novel therapeutic strategies targeting chaperone complexes in diseases characterized by epichaperome dysregulation, bridging the gap between fundamental research and precision medicine.
Quercetin Alleviates Liver Fibrosis via Neutrophil Infiltration Mediated by Glycolysis of Liver Sinusoidal Endothelial Cells
Authors: Chen Xiaoying , Wang Yifan , Wan Jie , Dou Xiaoyun , Zhang Chuzhao , Sun Meng , Ye Fang 
Published: April 2024

Abstract
Liver fibrosis is a prevalent characteristic in various chronic liver diseases, and glycolysis plays a pivotal role in this process. Quercetin (QE), as a natural flavonoid, has been reported to effectively regulate glycolysis. This study aimed to elucidate the effects of QE on liver fibrosis and its specific underlying mechanism.The results indicated that QE alleviated carbon tetrachloride (CCl4)-induced liver injury and fibrosis by improving pathological manifestations, thereby reducing the activities of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and total bilirubin (TBIL), as well as decreasing the serum levels of hyaluronic acid (HA), laminin (LN), and procollagen type III (PCIII). Additionally, QE downregulated lactate production in mice with liver fibrosis, as well as the mRNA and protein levels of rate-limiting enzymes in glycolysis such as PKM2, PFKP, and HK2. It also diminished the expression and activity of PKM2, PFKP, and HK2 in liver sinusoidal endothelial cells (LSECs), along with reducing glucose consumption and lactate production. Immunohistochemistry and immunofluorescence revealed that QE inhibited CXCL1 secretion in LSECs and impeded neutrophil recruitment. In summary, QE demonstrated its therapeutic potential for liver fibrosis by mitigating neutrophil infiltration through the inhibition of LSEC glycolysis.