bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microorganisms and bacterial cellulose stability of Kombucha under different manufacture and storage conditions
Authors: Li Binbin , Wang Xufeng , Wang Ping 
Published: April 2024

AbstractIt is crucial to clarify the stability of Kombucha in the manufacture and storage stages due to the extensive study on the fermented products of Kombucha and the increase in the use of bacterial cellulose (BC). This study aimed to evaluate the stability of Kombucha in different manufacturing and storage temperatures within a certain time period. The stability of microorganisms and BC in Kombucha was investigated through regular replacement with the tea media at 28 and 25°C for manufacture, and the storage temperature of Kombucha was at 25, 4, and −20°C. Morphological observations of the BC in Kombucha ended at 28 and 25°C for manufacture and storage were performed using atomic force microscopy (AFM) before inoculation. The viable cell counts and AFM results showed that the stability of Kombucha during manufacture was better at 28°C than at 25°C, with higher microbial viability and BC productivity in the former at the time of manufacture, whereas 25°C was more favorable for the stability of Kombucha during storage. At the same temperature of 25°C, the manufacturing practice improved the microbial viability and BC stability compared with storage; the pH value of Kombucha was lower, and the dry weight of BC was higher during storage compared with manufacture. The maximum BC water holding capacity (97.16%) was maintained by storage at 4°C on day 63, and the maximum BC swelling rate (56.92%) was observed after storage at −20°C on day 7. The research was conducted to provide reference information for applying Kombucha and its BC in food and development in other industries.
Gelling properties of acid‐induced tofu (soybean curd): Effects of acid type and nano‐fish bone
Authors: Khoder Ramy M. , Zhang Liangzi , Yin Tao , Liu Ru , You Juan , Wang Lan , Huang Qilin , Ma Huawei 
Published: April 2024

AbstractThe effects of different types of acid coagulants and nano fish bone (NFB) additives on the characteristics of tofu were investigated using texture analyzers, SEM, FT‐IR, and other techniques. The breaking force and penetration distance, in descending order, were found in the tofu induced by glucono‐d‐lactone (GDL) (180.27 g and 0.75 cm), citric acid (152.90 g and 0.74 cm), lactic acid (123.33 g and 0.73 cm), and acetic acid (69.84 g and 0.58 cm), respectively. The syneresis of these tofu samples was in the reverse order (35.00, 35.66, 39.66, and 44.50%). Lightness and whiteness were not significantly different among the different samples. Regardless of the acid type, the soluble calcium content in the soybean milk was significantly increased after adding NFB. As a result, the breaking force and penetration distance of all tofu samples increased significantly, but the syneresis decreased. Compared with tofu coagulated by other acids, GDL tofu formed a more uniform and dense gel network maintained by the highest intermolecular forces (especially hydrophobic interactions). Regarding the secondary structure, the lowest percentage of α‐helix (22.72%) and, correspondingly, the highest β‐sheet (48.32%) and random coil (18.81%) were noticed in the GDL tofu. The effects of NFB on the tofu characteristics can be explained by the changes in the gel network, intermolecular forces, and secondary structure, which were in line with the acid type. The characteristics of acid‐induced tofu can be most synergistically improved by coagulation with GDL and NFB.
Harnessing the dual nature of Bacillus (Weizmannia) coagulans for sustainable production of biomaterials and development of functional food
Authors: Maresca Emanuela , Aulitto Martina , Contursi Patrizia 
Published: April 2024

AbstractBacillus coagulans, recently renamed Weizmannia coagulans, is a spore‐forming bacterium that has garnered significant interest across various research fields, ranging from health to industrial applications. The probiotic properties of W. coagulans enhance intestinal digestion, by releasing prebiotic molecules including enzymes that facilitate the breakdown of not‐digestible carbohydrates. Notably, some enzymes from W. coagulans extend beyond digestive functions, serving as valuable biotechnological tools and contributing to more sustainable and efficient manufacturing processes. Furthermore, the homofermentative thermophilic nature of W. coagulans renders it an exceptional candidate for fermenting foods and lignocellulosic residues into L‐(+)‐lactic acid. In this review, we provide an overview of the dual nature of W. coagulans, in functional foods and for the development of bio‐based materials.
Retrospective case–control study on radiation dose for uterine artery embolization procedures
Authors: Nocum Don J , Liang Eisen Y 
Published: April 2024

AbstractIntroductionUterine artery embolization is performed in pre‐menopausal women. Understanding the contribution of radiation dose at each stage of the procedure is important for potential dose reduction. The aim was to retrospectively analyse radiation dose on a per‐procedural‐stage basis, comparing digital subtraction angiography (DSA) and conventional roadmap (CRM).MethodsGroup A consisted of 50 patients where DSA was used for road mapping at all stages: (I) Aortogram, (II) Left internal iliac artery (IIA) DSA, (III) Left uterine artery (UA) DSA, (IV) Right IIA DSA and (V) Right UA DSA. Group B included 50 patients, where CRM was used for road mapping at stages (II) and (IV).ResultsFor Group A, mean total dose‐area product (DAP) was 39.7 Gy·cm2; mean DAP for each stage were (I) Aortogram = 3.4 Gy·cm2, (II) Left IIA DSA = 5.9 Gy·cm2, (III) Left UA DSA = 3.2 Gy·cm2, (IV) Right IIA DSA = 5.5 Gy·cm2 and (V) Right UA DSA = 3.0 Gy·cm2. For Group B, mean total DAP was 33.6 Gy·cm2, mean DAP for each stage were (I) Aortogram = 3.3 Gy·cm2, (II) Left IIA CRM = 1.5 Gy·cm2, (III) Left UA DSA = 3.3 Gy·cm2, (IV) Right IIA CRM = 1.5 Gy·cm2 and (V) Right UA DSA = 3.3 Gy·cm2. Fluoroscopy time was 10 and 9.4 min for Groups A and B, respectively.ConclusionThe highest road‐mapping radiation dose contribution was from bilateral IIA DSA. The use of CRM, intermittent fluoroscopy and elimination of the aortogram is recommended to further reduce procedural radiation dose.
Autologous platelet concentrate in epiretinal membrane surgery: A single‐centre prospective comparative non‐inferiority study
Authors: Furashova Olga , Adrianowicz Bartlomiej , Engelmann Katrin 
Published: April 2024

AbstractPurposeThe purpose of the study was to compare the anatomical and functional results including reading ability after epiretinal membrane (ERM) surgery in patients with and without the use of autologous platelet concentrate (APC).MethodsDesign: Prospective, comparative non‐inferiority series. Setting: Institutional. Patients: 51 eyes of 51 patients, who underwent pars‐plana vitrectomy (PPV) for ERM surgery. 29 eyes additionally received intraoperative APC, 22 eyes underwent standard procedure without APC use. Observations: anatomical and functional outcome parameters (central retinal thickness (CRT), best corrected visual acuity (BCVA) and reading ability (RA)) were compared between the two groups at 6 weeks and 6 months postoperatively. Subjective assessment of visual acuity and reading ability was also analysed. Main outcome measures: BCVA, RA and CRT.ResultsBoth groups showed significant CRT reduction and RA improvement, while BCVA improvement was significant only in eyes with intraoperative APC use during the follow‐up time of 6 months. There was no statistically significant difference between CRT reduction, BCVA and RA improvement between the groups.ConclusionIntraoperative APC use for ERM surgery results in similar anatomical and functional outcomes compared with standard ERM surgery without APC use.
Letter: Diet‐microbiome interactions in inflammatory bowel disease—Navigating towards individualised dietary strategies
Authors: Barth Iris , Stevens Corien L. , Strokap Colette J. , Campmans‐Kuijpers Marjo J. E. , Bourgonje Arno R. , Dijkstra Gerard 
Published: April 2024

LINKED CONTENTThis article is linked to Faqerah et al paper. To view this article, visit https://doi.org/10.1111/apt.17720
Letter: Use of liver stiffness measurement to identify liver cirrhosis in patients with chronic hepatitis D—Authors' reply
Authors: Sandmann Lisa , Wedemeyer Heiner , Deterding Katja 
Published: April 2024

LINKED CONTENTThis article is linked to Sandmann et al papers. To view these articles, visit https://doi.org/10.1111/apt.17878 and https://doi.org/10.1111/apt.17923
Editorial: Recompensation in PBC is good. But is it good enough? Authors' reply
Authors: Hofer Benedikt Silvester , Burghart Lukas , Halilbasic Emina , Simbrunner Benedikt , Petrenko Oleksandr , Mandorfer Mattias , Stättermayer Albert Friedrich , Trauner Michael , Reiberger Thomas 
Published: April 2024

LINKED CONTENTThis article is linked to Hofer et al papers. To view these articles, visit https://doi.org/10.1111/apt.17908 and https://doi.org/10.1111/apt.17924
OpenSAFELY: The impact of COVID‐19 on azathioprine, leflunomide and methotrexate monitoring, and factors associated with change in monitoring rate
Authors: Brown Andrew D. , Fisher Louis , Curtis Helen J. , Wiedemann Milan , Hulme William J. , Speed Victoria , Hopcroft Lisa E. M. , Cunningham Christine , Costello Ruth E. , Galloway James B. , Russell Mark D. , Bechman Katie , Kurt Zeyneb , Croker Richard , Wood Chris , Walker Alex J. , Schaffer Andrea L. , Bacon Seb C. J. , Mehrkar Amir , Hickman George , Bates Chris , Cockburn Jonathan , Parry John , Hester Frank , Harper Sam , Goldacre Ben ,   The OpenSAFELY Collaborative, MacKenna Brian 
Published: April 2024

AimsThe COVID‐19 pandemic created unprecedented pressure on healthcare services. This study investigates whether disease‐modifying antirheumatic drug (DMARD) safety monitoring was affected during the COVID‐19 pandemic.MethodsA population‐based cohort study was conducted using the OpenSAFELY platform to access electronic health record data from 24.2 million patients registered at general practices using TPP's SystmOne software. Patients were included for further analysis if prescribed azathioprine, leflunomide or methotrexate between November 2019 and July 2022. Outcomes were assessed as monthly trends and variation between various sociodemographic and clinical groups for adherence with standard safety monitoring recommendations.ResultsAn acute increase in the rate of missed monitoring occurred across the study population (+12.4 percentage points) when lockdown measures were implemented in March 2020. This increase was more pronounced for some patient groups (70–79 year‐olds: +13.7 percentage points; females: +12.8 percentage points), regions (North West: +17.0 percentage points), medications (leflunomide: +20.7 percentage points) and monitoring tests (blood pressure: +24.5 percentage points). Missed monitoring rates decreased substantially for all groups by July 2022. Consistent differences were observed in overall missed monitoring rates between several groups throughout the study.ConclusionDMARD monitoring rates temporarily deteriorated during the COVID‐19 pandemic. Deterioration coincided with the onset of lockdown measures, with monitoring rates recovering rapidly as lockdown measures were eased. Differences observed in monitoring rates between medications, tests, regions and patient groups highlight opportunities to tackle potential inequalities in the provision or uptake of monitoring services. Further research should evaluate the causes of the differences identified between groups.
Self‐regulation and shared regulation in collaborative learning in adaptive digital learning environments: A systematic review of empirical studies
Authors: Sharma Kshitij , Nguyen Andy , Hong Yvonne 
Published: April 2024

AbstractAdaptive learning technologies are closely related to learners' self‐regulatory processes in individual and collaborative learning. This study presents the outcomes of a systematic literature review of empirical evidence on adaptive learning environments to foster self‐regulation and shared regulation of learning in collaborative settings. We provide an overview of what and how adaptive technologies have been used to understand and promote self‐regulated learning in collaborative contexts. A search resulted in 38 papers being analysed. Specifically, we identified the seven main objectives (feedback and scaffolding, self‐regulatory skills and strategies, learning trajectories, collaborative learning processes, adaptation and regulation, self‐assessment, and help‐seeking behaviour) that the adaptive technology research has been focusing on. We also summarize the implications derived from the reviewed papers and frame them within seven thematic areas. Finally, this review stresses that future research should consider developing a converging theoretical framework that would enable concrete monitoring and support for self‐regulation and socially shared regulation of learning. Our findings set a baseline to support the adoption and proliferation of adaptive learning technology within self‐regulated learning research and development.
Practitioner notesWhat is already known about this topic

By providing personalized and learner‐centric adaptive learning environments (ADLEs), adaptive learning technology can support and foster self‐regulated learning (SRL) practices.
It is possible to create a more student‐centred and effective learning environment by combining adaptive learning and collaborative learning.
Socially shared regulatory activities can involve planning, monitoring, controlling and reflecting on a group's learning processes.
What this paper adds

Provides a systematic literature review of empirical evidence on ADLEs, SRL and socially shared regulation of learning (SSRL) in collaborative contexts.
Summarizes the insights on (S)SRL through ADLEs in collaborative learning.
Identifies challenges and opportunities for ADLEs to support (S)SRL in collaborative learning.
Implications for practice and/or policy

Learning analytics and educational technology researchers will be able to use the systematic review as a guide for future research.
Learning analytics and educational technology practitioners will be able to use the systematic review as a summary of the field's current state.
Ageing, osteoporosis and intellectual disability; risks differ, and diagnosis can be missed
Authors: Burke Eilish A. , Carroll Rachael , O'Dwyer Maire , Walsh J Bernard , McCallion Philip , McCarron Mary 
Published: April 2024

AbstractBackgroundPeople with intellectual disability often present atypically for various health conditions, making it challenging to identify concerns, particularly when communication challenges are also considered. Additionally, they may face barriers to healthcare access, resulting in many conditions going unnoticed. Health screening inequities are also evident in this population, and osteoporosis, a silent condition often only diagnosed postfracture, requires screening; however, if this does not happen, it may result in unnecessary fracture. Therefore the aim of this study is to identify predictors of osteoporosis in older adults with intellectual disability and examine potential inequity in the diagnosis of the condition.MethodsThe study used data from the Intellectual Disability Supplement to The Irish Longitudinal Study on Ageing (IDS‐TILDA). Bone quality was measured using quantitative ultrasound (QUS). Logistic regression was performed to identify significant predictors of poor bone quality, including chronic health conditions, dietary intake, medication use and activity levels.ResultsOut of 575 participants who completed QUS, osteoporosis prevalence was objectively measured at 41%, with a further 33.2% measured within the osteopenic range, but less than 2 in 10 had a doctor's diagnosis of osteoporosis. Reported Dual‐Energy X‐ray Absorptiometry screening uptake was low at 18.2%. Three major predictor variables of osteoporosis and osteopenia were found significant: difficulty walking 100 yards, taking antiepileptic drugs medicines and taking proton pump inhibitors. The model achieved an overall classification accuracy of 70.8% for osteopenia and 72.5% for identifying osteoporosis.ConclusionThe study highlights the different risk factors in people with intellectual disability, the potential for missed diagnoses and the likelihood there is inadequate screening. There is an urgent need for robust risk assessment and reasonable adjustments to ensure equitable screening and targeted preventive strategies. Clinicians must consider specific concerns for this population to avoid missed diagnoses and reduce the adverse effects of osteoporosis/osteopenia, such as an increased risk of fragility fractures.
Molecular detection of Lotmaria passim in intestine of Japanese honeybees (Apis cerana japonica)
Authors: Suzuki Akihiko , Sakamoto Yoshiko 
Published: April 2024

ABSTRACTCrithidia mellificae and Lotmaria passim are trypanosomatids that infect honeybees, and many studies suggest that both parasites contribute to the decline in the honeybee population. The Japanese honeybee (Apis cerana japonica) is a native honeybee that inhabits various areas of Japan and is one of the most important pollinators. Both parasites have been well studied in the western honeybee (Apis mellifera) but have been poorly investigated in A. c. japonica. The present study investigated the presence of C. mellificae and L. passim in one feral and six managed A. c. japonica colonies at three different institutes. Five out of seven colonies were polymerase chain reaction‐positive for L. passim (71.4%); however, C. mellificae was not detected. Four of the five colonies were positive in both the midgut and hindgut, but one was positive only in the hindgut. A homology search and phylogenetic tree of the glycosomal glyceraldehyde‐3‐phosphate dehydrogenase (gGAPDH) and cytochrome b (Cytb) genes obtained in this study indicated that the sequences belonged to L. passim. The results of this study emphasize concerns regarding the health of this ecologically important pollinator and the importance of further investigation of the prevalence of L. passim in A. c. japonica in a wider area of Japan.
Presence of immunoglobulin E‐expressing antibody‐secreting cells in the dermis close to bullous pemphigoid lesions
Authors: Budair Fatimah , Kambe Naotomo , Kogame Toshiaki , Hirata Masahiro , Takimoto‐Ito Riko , Mostafa Alshimaa , Nomura Takashi , Kabashima Kenji 
Published: April 2024

AbstractAntibody‐secreting cells (ASCs) produce immunoglobulin (Ig) G and IgE autoantibodies in secondary lymphoid organs. Evidence also suggests their existence in the skin in various chronic inflammatory conditions, and in association with CXCL12 and CXCL13, they regulate the recruitment/survival of ASCs and germinal center formation to generate ASCs, respectively. However, the presence of IgG and IgE in bullous pemphigoid (BP) lesions needs to be addressed. Here, we aimed to analyse BP skin for the presence of IgG and IgE and the factors contributing to their generation, recruitment, and persistence. Skin samples from 30 patients with BP were stained to identify ASCs and the immunoglobulin type they expressed. The presence of tertiary lymphoid organ (TLO) elements, which generate ASCs in non‐lymphoid tissues, and the chemokines CXCL12 and CXCL13, which regulate the migration/persistence of ASCs in lymphoid tissues and formation of TLOs, respectively, were evaluated in BP skin. BP skin harboured ASCs expressing the two types of antibodies IgG and IgE. ASCs were found in high‐grade cellular aggregates containing TLO elements: T cells, B cells, CXCL12+ cells, CXCL13+ cells and high endothelial venules. IgG+ ASCs were detected among these aggregates, whereas IgE+ ASCs were dispersed throughout the dermis. CXCL12+ fibroblast‐like cells were located close to ASCs. The inflammatory microenvironment of BP lesions may contribute to the antibody load characteristic of the skin of patients with BP by providing a site for the presence of ASCs. CXCL13 and CXCL12 expression may contribute to the generation and recruitment/survival of ASCs, respectively.
Maximum sustainable employment: Adding to the beacons of wild fisheries governance
Authors: Bavinck Maarten , Scholtens Joeri , Fabinyi Michael 
Published: April 2024

AbstractThis paper proposes to establish Maximum Sustainable Employment (MSE) as a new guiding light, or beacon, for wild fisheries governance. This new social beacon complements the directives provided by the prevailing beacons: Maximum Sustainable Yield (MSY) and Maximum Economic Yield (MEY). The argument is that context matters: in countries where poverty levels are high and alternative employment is scarce, fisheries governors cannot limit themselves to a sectoral perspective. Instead, they must include the remunerative employment and ‘decent work’ that wild fisheries offer society in their strategic deliberations. This perspective is especially relevant for countries in the Global South, but it also has a bearing on the Global North. After discussing the history of scientific fisheries management and the relevance of employment in fisheries, the paper considers the arguments made against MSE. It concludes with a reflection on the balancing of the three beacons in line with prevailing circumstances.
Characterisation of resistant starch from Vigna unguiculata for the development of an oral‐colon delivery agent
Authors: Sewnarain Priyanta , Dwarka Depika , Mellem John J. 
Published: April 2024

SummaryThere is a significant concern associated with the delivery of chemotherapeutics to the colon due to limited drug absorption in the gastrointestinal tract. Starch has received great interest as a delivery agent owing to its cost efficacy and high availability. In this study, native resistant starch and acid‐modified resistant starch from Vigna unguiculata were used to produce microcapsules containing camptothecin as an oral‐colon‐specific drug delivery agent. Functional characteristics such as solubility, swelling power, amylose content, emulsifying, foaming together with water and oil absorption capacity of native resistant starch and acid‐modified resistant starch were established. The prepared microcapsules were characterised and subjected to simulated digestion with the obtained residue evaluated for cytotoxicity using the MTT assay. It was observed that acid‐modified resistant starch had the best functional properties (water absorption capacity: 2.76 g g−1, oil absorption capacity: 3.13 g g−1, amylose: 35%, foaming capacity: 17.73%, and emulsifying activity: 33.33%) as compared to its native resistant starch (water absorption capacity: 2.03 g g−1, oil absorption capacity: 2.81 g g−1, amylose: 32%, foaming capacity: 4% and emulsifying activity: 23.56%). The microcapsules had a particle size of 0.25–0.35 μm, moisture content between 1.12% and 3.41% and a high encapsulation efficiency of 96.40 and 98.96% for native resistant starch and acid‐modified resistant starch capsules respectively. Results for MTT assay showed cancerous cells to be inhibited by microcapsules with noncancerous cells less affected.