bluuebunny/crossref_metadata_2025_split huggingface dataset:
Brain Structural and Functional Abnormalities Associated with Acute Post-Traumatic Headache: Iron Deposition and Functional Connectivity
Authors: Nikolova Simona , Chong Catherine , Li Jing , Wu Teresa , Dumkrieger Gina , Ross Katherine , Starling Amaal , Schwedt Todd J. 
Published: March 2024

Abstract

Background
The purpose of this study was to interrogate brain iron accumulation in participants with acute post-traumatic headache (PTH) due to mild traumatic brain injury (mTBI), and to determine if functional connectivity is affected in areas with iron accumulation. We aimed to examine the correlations between iron accumulation and headache frequency, post-concussion symptom severity, number of mTBIs and time since most recent TBI.
Methods
Sixty participants with acute PTH and 60 age-matched healthy controls (HC) underwent 3T magnetic resonance imaging including quantitative T2* maps and resting-state functional connectivity imaging. Between group T2* differences were determined using T-tests (p < 0.005, cluster size threshold of 10 voxels). For regions with T2* differences, two analyses were conducted. First, the correlations with clinical variables including headache frequency, number of lifetime mTBIs, time since most recent mTBI, and Sport Concussion Assessment Tool (SCAT) symptom severity scale scores were investigated using linear regression. Second, the functional connectivity of these regions with the rest of the brain was examined (significance of p < 0.05 with family wise error correction for multiple comparisons).
Results
The acute PTH group consisted of 60 participants (22 male, 38 female) with average age of 42 ± 14 years. The HC group consisted of 60 age-matched controls (17 male, 43 female, average age of 42 ± 13). PTH participants had lower T2* values compared to HC in the left posterior cingulate and the bilateral cuneus. Stronger functional connectivity was observed between bilateral cuneus and right cerebellar areas in PTH compared to HC. Within the PTH group, linear regression showed negative associations of T2* and SCAT symptom severity score in the left posterior cingulate (p = 0.05) and with headache frequency in the left cuneus (p = 0.04).
Conclusions
Iron accumulation in posterior cingulate and cuneus was observed in those with acute PTH relative to HC; stronger functional connectivity was detected between the bilateral cuneus and the right cerebellum. The correlations of decreased T2* (suggesting higher iron content) with headache frequency and post mTBI symptom severity suggest that the iron accumulation that results from mTBI might reflect the severity of underlying mTBI pathophysiology and associate with post-mTBI symptom severity including PTH.
Heterogeneous Impact of Oil Prices Shocks on Exchange Rates in Oil Exporting Countries: Evidence of Quantiles-On -Quantiles Approach.
Authors: Joseph ATEBA , Dieudonne EWONDO , Armando ABEGA Daniel 
Published: March 2024

Abstract
In this study, the researchers used the exchange rates returns of both low incomes, emerging and developed majors’ oil exporting countries, and decomposed oil price shocks to study the heterogeneity of the intrinsic dynamic between the two variables in these countries, using the quantile-on-quantile analysis. The findings revealed that, there are important variability of the shocks impacts across the quantile distribution of both exchange rates returns and the different oil price shocks. More precisely, the study revealed the heterogeneity of the different oil shocks impacts (oil aggregate demand, oil supply and oil specific demand shocks) on the exchange rates return of a given country, with the shape of the QQR graphs being different according to the source of shock and the magnitude of oil demand and oil specific demand shocks being more significant than that of oil supply shocks in many of the cases. In the same way, the analysis results also indicate that the dynamic between oil price shocks and exchange rate is heterogeneous across the countries, with the impact of the shocks being more significant in developing countries than it is in developed countries. As well the behavior of the exchange rates returns at extreme values is different from one country to another. From this insight, the researchers recommend an economy diversification mainly for oil developing countries, and country-specific economy policies to mitigate the incidence of oil shocks, as the impact differs from one country to another.
Cohort Builder: A Software Pipeline for Generating Patient Cohorts with Predetermined Baseline Characteristics from Medical Records and Raw Ophthalmic Imaging Data
Authors: Mousavi Sepehr , Garjani Ali , Elwakil Adham , Brock Laurent Pierre , Dherse Alexandre Pierre , Forestier Edwige , Palaz Marine , Seiler Emilien , Duriez Alexia , Martin Thibaud , Wolfensburger Thomas , Schlingemann Reinier , Meloni Ilenia , Tomasoni Mattia 
Published: March 2024

Abstract
In clinical research, the analysis of patient cohorts is a widely employed method for investigating relevant questions in healthcare. Furthermore, the availability of large-scale datasets opens the way for the integration of AI models into clinical practices. The ability to extract appropriate patient cohorts and large-scale datasets from hospital databases is vital in order to unlock the potential of real-world data collected in clinics and answer pivotal medical questions through retrospective studies. However, existing medical data is often dispersed across various systems and databases, preventing a systematic approach allowing access and interoperability. Even when the data are readily accessible, researchers need to systematically combine them to form study-specific cohorts with predefined baseline characteristics, tailored to answer specific research inquiries. This process is costly, repetitive, and error-prone, as it requires sifting through Electronic Medical Records, confirming ethical approval, verifying status of patient consent, checking the availability of imaging data, and filtering based on disease-specific image biomarkers. Our objective is to give the ability to craft study-specific patient cohorts to clinical researchers through an automated data preparation and processing pipeline. We present Cohort Builder, a software pipeline designed to facilitate the creation of patient cohorts with predefined baseline characteristics from real-world ophthalmic imaging data and electronic medical records. The applicability of our approach extends beyond ophthalmology to other medical domains with similar requirements such as neurology, cardiology and orthopaedics.
The normal microbiota of the ocular surface and the connection between the changes in its composition and ophthalmic pathologies
Authors: Rezbaeva G. N. , Orenburkina O. I. , Gimranova I. A. , Babushkin A. E. , Gazizullina G. R. 
Published: March 2024

The microflora of the ocular surface serves an important role in the protective mechanisms, since it significantly affects the regulation of immunological activity and the barrier effect against pathogen invasion. The presence of a healthy ocular microbiome causes no eye diseases, and ophthalmic pathologies develop only when anatomical barrier functions and immune status are violated. A healthy eye surface is characterized by a relatively stable and small microbiome diversity. The environment, diet, gender, age and some other factors, such as potential contamination, affect the composition of the microbial flora, complicate its analysis and may affect the results of the latter. Moreover, potentially pathogenic organisms various disorders, including inflammation and methods of treating ocular surface can also affect the composition of eye microbioma. Traditional microbiological studies based on cultivation often reveal a rather low diversity of microorganisms in a particular region. New research methods, e.g. genetic analysis based on rRNA sequencing, indicate a much greater diversity than previously assumed. It has been shown that changes in the microbiota composition occur in blepharitis, conjunctivitis, keratitis, uveitis, dry eye syndrome, age-related macular degeneration, diabetic retinopathy, glaucoma, myopia, etc.Currently, there are no clear criteria for describing norms of the ocular microbiome (including fluctuations which should be considered normal during life). The features and impact of the microflora composition on immunity and human body as a whole, in particular, those associated with the intestinal microbiome and their dependence on gender, age, place of residence, etc have not been studied in full.Further studies of eye microbiome can give answers to all these questions.
Assessment of anti-inflammatory therapy effectiveness in the early postoperative period of cataract surgery
Authors: Bikbov M. M. , Usubov E. L. , Kazakbayeva G. M. , Galimov A. U. , Pokhilko N. I. , Valishin I. D. , Nizamutdinova A. M. 
Published: March 2024

Purpose: To evaluate the efficacy and safety of nonsteroid anti-inflammatory drugs (NSAIDs) in monotherapy and as part of combination therapy with glucocorticosteroids for the prevention of postoperative inflammation after cataract phacoemulsification.Material and methods. The study included 75 patients who underwent phacoemulsification with implantation of a posterior chamber intraocular lens. Patients were divided into groups depending on anti-inflammatory treatment: A1 — nepafenac (Nepafenac-Optic), A2 — bromfenac (Broxinac), A3 — dexamethasone (Dexamethasone), B1 — Nepafenac-Optic + dexamethasone, B2 — bromfenac + Dexamethasone. Postoperative inflammation was assessed by the severity of conjunctival hyperemia, pain, Tyndall effect and retinal thickness in the macular region.Results. The severity of the pain symptom was lower in the nepafenac group (A1) as compared to groups A2 and A3 by 49 and 74 %, respectively. A strong direct correlation with the Tyndall effect was revealed, which was more pronounced in group A3 and amounted to 0.73 points. An increase in the thickness of the retina in the macular region in the early stages after surgery was observed in groups A2 and A3, on average by 30 microns. In the groups of Nonpafenac Optic and combined therapy with GCS, the thickness of the retina remained stable. Cystic macular edema in the early postoperative period was observed in groups A2 and A3 and amounted to 2.6 and 1.3 %, respectively. There was a tendency to higher IOP rates in the GCS therapy groups.Conclusion. After surgical treatment of cataracts, the Nepafenac Optic significantly relieves the pain syndrome, as compared with monotherapy with bromfenac or dexamethasone. Nepafenac-Optic helps to reduce the severity of inflammation in the anterior and posterior segments of the eye, minimizes the changes in the retinal thickness of the macular region in the postoperative period. The severity of these effects is comparable to the combination therapy of NSAIDs + GCS. Nepafenac-Optic does not increase IOP, has a more favorable safety profile than in combinations with glucocorticosteroids, and reduces the risk of postoperative complications.
The investigation of the association of alleles and genotypes of the polymorphic marker T786C of the eNOS gene at various stages of primary open-angle glaucoma
Authors: Gavrilova T. V. , Kinkulkina A. R. , Avagyan A. S. , Svitich O. A. 
Published: March 2024

Purpose: to study the association of the polymorphic marker T786C of the eNOS gene with various stages of primary open-angle glaucoma (POAG).Materials and methods. Peripheral blood of 90 patients aged 56 to 89 yrs (ave. 71 yrs) with POAG stages I, II, III was tested. DNA was isolated using a set of ribosorbents (Synthol company); subsequently, a real-time PCR reaction was performed on a DT-96 amplifier using the set to determine the polymorphic marker T786C in the eNOS gene.Results. For all groups of patients, the frequency of occurrence of alleles and genotypes was calculated, and the relationship between the emergence of POAG and the presence of an unfavorable polymorphic marker was determined. The main changes were revealed at POAG stages II and III, whilst at stage I no effect of polymorphism T786C of the eNOS gene was observed.Conclusion. For the first time, a comparative assessment was made of the distribution of alleles and genotypes by the polymorphic marker T786C in the eNOS gene of patients with various POAG stages.
The first experience of parallel measurements of objective accommodation parameters in children with myopia using various instruments: in search of a common denominator
Authors: Neroev V. V. , Tarutta E. P. , Kondratova S. E. 
Published: March 2024

Purpose: to study the relationship between the parameters of reflex and tonic accommodation measured using various objective methods.Material and methods. A comprehensive parallel study of objective accommodation parameters of 57 children (114 eyes) with low and moderate myopia (average -2.6 ± 1.4 D) aged from 8 to 12 years (average 9.9 ± 1.6 years) was carried out on three devices: Grand Seiko WAM-5500K, Acomoref 2 K-model Righton; TONOREF III, Nidek.Results. Both coincidences and differences of the indicators obtained by different methods as well as their correlations were revealed: positive - between the values of AR in the open field and in the virtual space (r = 0.23, r = 0.2); between the virtual responses to Righton K-2 and Nidek (r = 0.38); direct correlations of the accommodation response with accommodation tones. A correlation of average strength (r = 0.44) was found between the HAT on the Grand Seiko WR-5100K and the CMF on the Righton K2, which allows us to consider them as synonymous indicators. A negative relationship of CMF with PRA and SE refraction was found. A positive correlation of CMF with the rate of progression of myopia and a negative one with PRA suggests that a high CMF is a bad prognostic sign. However, CMF positively correlates with the magnitude of the accommodative response on all three devices. In this case, it turns out that an increase in CMF accompanies an increase in the amplitude of accommodation and, therefore, is not always a troublesome factor. Perhaps we are dealing with the limits of the norm for this indicator, which still need to be studied.Conclusion. With the help of objective methods of studying qualitatively different characteristics of one process, it is possible to investigate the actual and prognostic parameters of accommodation, which will allow us to offer an individualized approach to the treatment of patients with myopia using optical and drug instruments.
Experimental rationale for the use of thioctic acid and indomethacin in the therapy of the early stage of retinal neurodegeneration
Authors: Neroev V. V. , Pavlenko T. A. , Chesnokova N. B. , Beznos O. V. , Okhotsimskaya T. D. , Panova A. Yu. 
Published: March 2024

Purpose: to assess the possibility of using thioctic acid and indomethacin tin eyedrops for the therapy of early stages of retinal neurodegeneration.Material and methods. The study was performed on 20 Chinchilla rabbits, including 16 rabbits in whom the neurodegenerative process in the retina was produced by intravitreal installation of 6-hydroxydopamine (6-OHDA), 0.25 mg per eye, and 4 rabbits (8 eyes) served as control. Thioctic acid 0.5% and Indocollir 0.1% were instilled separately and in combination 5 times daily for 7 days after the injection of 6-OHDA. Pupillary light reaction was estimated and eye fundus condition analyzed. Alpha2-macroglobuline ( 2-MG) and SOD activity, dopamine and protein concentrations were measured in retinal homogenates.Results. Instillations of thioctic acid reduced the retinal damage area almost by half as compared to the untreated group (p d 0.005). Indomethacin was less effective, but the combination of the two drugs brought about a maximal reduction of the damage area (p d 0.05 against the untreated group). Both preparations normalized the disturbed pupillary light reaction. The injection of 6-OHDA caused a decrease of dopamine concentration in the retina (0.050 ± 0.009 pg/mg as against 0.095 ± 0.031 pg/mg in healthy controls, р d 0,05). After instillations of indomethacin and thioctic acid, the concentration tended to increase, and it increased significantly after treatment with their combination (0.141 ± 0.037 pg/mg, p d 0.01 as against untreated animals). The activity of 2-MG in retina decreased after a 6-OHDA injection (2.93 ± 0.42 pg/mg as against 5.5 ± 1.2 pg/mg in healthy controls, р < 0 005) just as they increased the decreased SOD (13.30 ± 5.68 U/mg in healthy controls, 5.41 ± 1.50 U/mg in untreated animals, р < 0.05). Both preparations applied separately or in combination caused a significant increase of 2-MG activity (thioctic acid — 4.19 ± 0.91 pg/mg, indomethacin — 6.95 ± 1.09 pg/mg, combination — 7.25 ± 0.63 pg/mg, р < 0.05 as against the untreated animals) and SOD activity (thioctic acid — 8.25 ± 1.27 U/mg, indomethacin — 29.84 ± 6.63 U/mg, combination — 23.99 ± 3.78 U/mg, р < 0.01 as against the untreated animals).Conclusion. The combination of indomethacin and thioctic acid in eyedrops is the most effective for the prevention of eye damage caused by 6-OHDA, which makes this method promising for the treatment of eye diseases accompanied by neurodegeneration.
Vertical Vibratory Mixers in Flour-Mixing Technology
Authors: Borodulin Dmitry , Shulbaeva Margarita , Musina Olga , Sukhorukov Dmitry 
Published: March 2024

The food industry is currently demonstrating a tendency to substitute traditional high-humidity raw materials with their dry analogues. This research introduces new designs of vertical vibrating mixers that could preprogram flour mix quality. The vertical continuous vibration mixers designed for granular materials showed a good potential for a wider scope of application.
The experiment involved high-quality wheat flour, sugar, salt, egg powder, and powdered milk, as well as three vertical mixers, i.e., a lifting mixer, a flow mixer, and a cascade mixer.
Wheat flour entered the working body of the mixer and came into a stable vibration-boiling state in layers of ≤ 35 mm with a vibration amplitude of 4.5 mm and a frequency of ≥ 20 Hz. The speed rate of the flour increased together with the oscillation frequency of the working body and the size of the perforation area but went down as the layer grew wider. The efficiency increased following the increase in the perforation area on the spiral surface and depended on the maximal thickness of the dough layer. The flow vibrating mixer proved to be the most effective one. The frequency of pulse feeding of ingredients into the mixer was ≤ 50% (Vc ≤ 14.5%) to obtain flour mixes of satisfactory quality while good-quality mixes required 25% average time the particles spent in the mixer (Vc ≤ 6%).
The results obtained can be used to design technological lines for flour mix production.
Identification of Severe Grading in Knee OsteoArthritis from MRI using
Ensemble Deep Learning
Authors: Alyami Jaber 
Published: March 2024

Background:
Accurate finding of Knee Osteoarthritis (KOA) from structural Magnetic Resonance Imaging (MRI) is a difficult task and is greatly subject to user
variation. Furthermore, the identification of knee osteoarthritis (KOA) from MRI scans presents a challenge due to the limited information
available. A novel methodology using an ensemble Deep Learning algorithm, combining EfficientNet-B3 and ResNext-101 architectures, aims to
forecast KOA advancement, bridging the identified gap in clinical trials.

Objectives:
The study aims to develop a precise predictive model for knee osteoarthritis using advanced deep-learning architectures and structural MRI scan
data. By utilizing an ensemble technique, the model's accuracy in predicting disease development is enhanced, surpassing the limitations of
traditional biomarkers.

Methods:
The study used the Osteoarthritis Initiative dataset to develop an ensemble Deep Learning model that combined EfficientNet-B3 and ResNext-101
architectures. Techniques like cropping, gamma correction, and in-slice rotation were used to expand the dataset and improve the model's
generalization capacity.

Results:
The Deep Learning model demonstrated 93% validation accuracy on the OAI dataset, accurately capturing subtle patterns of knee osteoarthritis
progression. Augmentation approaches enhanced its resilience

Conclusion:
Our ensemble Deep Learning approach, using ResNext-101 and EfficientNet-B3 architectures, accurately predicts knee osteoarthritis courses using
structural MRI data, demonstrating the importance of data augmentation for improved predictive tools.
Emerging Technologies for Sensitive Detection of Organophosphate
Pesticides: A Review
Authors: Kumaravel A. , Aishwarya S. , Sathyamoorthi S. 
Published: March 2024

Abstract:
The use of organophosphate pesticides (OPPs) in agricultural practices improves crop
yield and controls pests, but their indiscriminate use and persistence in the environment pose significant
health risks. Therefore, it has become increasingly important to develop reliable and efficient
detection methods for OPPs to ensure food safety and monitor their presence. In recent years, OPP
detection methods have undergone significant advancements. Sensors such as colorimetric, fluorescence,
electrochemical, and impedometric offer several advantages over traditional methods, such as
high sensitivity, selectivity, and portability. The purpose of this review paper is to provide an overview
of recent developments in OPP detection methods. The paper discusses the different types of
sensors that are available for the detection of OPPs, as well as their advantages and disadvantages.
Many electrochemical methods have been employed to investigate OPP detection, including voltammetry,
impedance spectroscopy, and amperometry. The integration of nanomaterials, such as carbon
nanotubes, graphene, and metal nanoparticles, has significantly enhanced the performance of
electrochemical sensors by providing high surface area, enhanced electron transfer, and specific analyte
interactions. Furthermore, the review discusses the utilization of biomolecules, such as enzymes
and aptamers, as recognition elements in sensor platforms for selective and sensitive OPP detection.
The incorporation of these biomolecules offers high specificity and enables real-time monitoring of
OPP residues in food samples and environmental matrices. It emphasizes the importance of continued
research and development to optimize detection methods, improve sensor performance, and
make these technologies more widely accessible for effective monitoring and control of OPP contamination
in various domains.