bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Public's Intended Uptake of Hypothetical Esophageal Adenocarcinoma Screening Scenarios: A Nationwide Survey
Authors: Sijben Jasmijn , Rainey Linda , Maas Fleur , Broeders Mireille J.M. , Siersema Peter D. , Peters Yonne 
Published: April 2024

INTRODUCTION:
Screening for early esophageal adenocarcinoma (EAC) may potentially reduce EAC-related mortality and morbidity. This study aimed to examine the Dutch population's intended uptake of 3 hypothetical EAC screening test scenarios and preferences for potential future organization.

METHODS:
A total of 8,350 Dutch individuals aged 45–75 years were invited, of whom 2,258 completed a web-based survey. Participants were randomly assigned to 1 of 3 hypothetical screening test scenarios (i.e., transnasal endoscopy, ingestible cell collection device, or breath analysis). The primary outcome was intended uptake. Secondary outcomes included acceptance of screening eligibility criteria and preferences regarding invitation, counseling, and diagnostic follow-up. We performed exploratory univariable and multivariable regression analyses to assess which determinants were associated with EAC screening intent.

RESULTS:
Intended uptake of screening was highest in the breath analysis scenario (95%), followed by conventional upper endoscopy (78%), an ingestible cell collection device (75%), and transnasal endoscopy (68%) (P < 0.001). Anticipating discomfort was most strongly associated with decreased intention to undergo transnasal endoscopy (odds ratio 0.18, 95% confidence interval 0.11–0.29) or swallow a cell collection device (odds ratio 0.20, 95% confidence interval 0.13–0.32). Cancer worry and high acceptance of test sensitivity/specificity were consistently associated with a positive intention to participate in screening. Inviting persons for screening based on gastroesophageal reflux disease symptoms, age, or the output of a risk prediction model was acceptable to 74%, 69%, and 66%, respectively. Inviting only men was acceptable for only 41% of women. The majority (58%) preferred to be invited by a public health organization, and 32% of the participants preferred to discuss their decision to participate with a healthcare professional.

DISCUSSION:
Participants in this study self-selected through a web-based survey, potentially introducing selection bias. Participants generally intended to participate in EAC screening, although the level of intent depended on the discomfort and performance associated with the offered screening test. Determining eligibility based on gastroesophageal reflux disease symptoms, age, or a risk calculator, but not sex, would be acceptable to most individuals.
Judicious Use of Ozanimod for Ulcerative Colitis and Multiple Sclerosis
Authors: Jhon Gabriela F. , Forster Erin M. 
Published: April 2024

ABSTRACT
Clinical trials have demonstrated the efficacy of ozanimod, an oral sphingosine-1-phosphate receptor modulator, for the treatment of moderate-to-severe ulcerative colitis. Infrequently does an opportunity present itself to use one drug for two simultaneous disease states, proving especially beneficial in the case of this patient intolerant of numerous established therapies for ulcerative colitis. This case report describes the successful use of ozanimod for both ulcerative colitis and multiple sclerosis, achieving clinical remission in both diseases.
Timing of onset of menses after GnRH agonist treatment for central precocious puberty
Authors: Klein Karen O. , Vargas Trujillo Marcela , Dragnic Sanja , Van Komen Stephen , Li Moming , Lee Peter A. 
Published: April 2024

Abstract

Objectives
To understand possible predictors of the onset of menses after gonadotropin-releasing hormone agonist treatment cessation in girls with central precocious puberty (CPP).

Methods
This exploratory post hoc analysis of a phase 3 and 4 trial of girls with CPP treated with once-monthly intramuscular leuprolide acetate examined onset of menses after treatment completion using a time-to-event analysis. Pretreatment and end-of-treatment chronologic age (CA), bone age (BA)/CA ratio, and Tanner breast stage; pretreatment menses status; and end-of-treatment BA and body mass index (BMI) were studied as potential factors influencing the onset of menses.

Results
Median time to first menses after stopping treatment was 18.3 months among 35 girls (mean age at onset of treatment, 6.8 years) examined. Of 26 girls experiencing menses, 11 (42 %) menstruated at 16–21 months after stopping treatment. Most girls with pretreatment BA/CA≥1.4 started menstruating very close to 18 months after stopping treatment; those with less advanced BA/CA experienced menses at 9–18 months. End-of-treatment BA/CA≥1.2 was associated with a quicker onset of menses (14.5 vs. 18.5 months for BA/CA<1.2, p=0.006). End-of-treatment BA≥12 years predicted longer time to menses. No relationship with time to menses was observed for pretreatment menarche status, pretreatment or end-of-treatment Tanner breast stage (<3/≥3) or CA (<6/≥6 or ≤11/>11), or end-of-treatment BMI percentiles (<85.6/≥85.6 and <92.6/≥92.6).

Conclusions
Pretreatment menarche status or CA do not appear to predict onset of menses, but pre- and end-of-treatment BA/CA may be helpful in anticipating time to first menses after stopping treatment.
A 14-year-old girl with premature ovarian insufficiency but with a positive pregnancy test
Authors: Touwslager Robbert N.H. , Zwaan C. Michel , Bakker Boudewijn , Lentjes Eef G.W.M. , Looijenga Leendert H.J. , van Santen Hanneke M. 
Published: April 2024

Abstract

Objectives
Childhood cancer survivors are at risk for premature ovarian insufficiency, especially after treatment with alkylating agents. The objective of this report is to highlight a case in which this phenomenon caused a false-positive pregnancy test.

Case presentation
A workup was performed in a 14-year-old girl with a positive pregnancy test. She was diagnosed with stage IV neuroblastoma of the left adrenal gland at the age of 4 years. She received extensive treatment, including alkylating agents, and had been diagnosed with premature ovarian insufficiency. An LH/hCG suppression test was performed using high dose 17 bèta-estradiol: hCG levels normalized.

Conclusions
The pregnancy test was false-positive due to production of low amounts of hCG by the pituitary gland as a result of high LH concentrations following premature ovarian insufficiency. It may be helpful to perform the LH/hCG suppression test to prove pituitary origin of the hCG overproduction.
Effect of anterior femoral cortical notch grade on postoperative function and complications during TKA surgery: A multicenter, retrospective study
Authors: Jin Zhaokai , Wang Zhengming , Xu Kuangying , Chu Jiahao , Xiang Sicheng , Tang Yi , Wang Rui , Hua Haotian , Zhang Zhongyi , Tong Peijian , Lv Shuaijie 
Published: April 2024

Abstract

Purpose
To explore the effect of AFN on knee function and complications in patients after TKA.

Methods
We evaluated 150 patients undergoing unilateral TKA, specifically including 102 patients with varying degrees of AFN after selection. They were divided into four groups based on AFN grade. About 48 patients did not produce AFN, 63 patients were grade I, 29 patients were grade II, and 10 patients were grade III. All patients were followed up for 24 months, and knee function, pain, complications, and other indicators were compared between the four groups. Correlation analysis and regression analysis were used to study the relationship between AFN and other indicators.

Results
Two cases of periprosthetic fractures (PPF) occurred in our study, with an incidence of 1.35%, which did not show a significant association with AFN. The changes in knee social score (ΔKSS), Western Ontario and McMaster Universities Osteoarthritis Index (ΔWOMAC), and postoperative anterior knee pain visual analog scale (VAS) score were higher in patients with AFN than in those without. Particularly, grades II and III AFN demonstrated superior efficacy. Pearson’s correlation analysis showed that AFN grade is positively correlated with both ΔKSS and ΔWOMAC (r = 0.44, P < 0.001), and AFN grade had a negative correlation with the anterior knee pain VAS (r = −0.250, P < 0.05). In linear regression analysis, AFN grade was positively correlated with both ΔKSS (β = 5.974, 95% CI: 3.968–7.981, P < 0.001) and ΔWOMAC (β = 6.356, 95% CI: 4.223–8.490, P < 0.001). Besides that, there was a negative correlation between AFN grade and anterior knee pain (β = 5.974, 95% CI: 3.968–7.981, P < 0.05).

Conclusion
Patients with grade II and III AFN who underwent TKA exhibited better knee function and lower levels of anterior knee pain post-surgery.
Optimize the corrosion behaviour and mechanical properties of AISI 316 stainless steel under heat treatment and previous cold working
Authors: Lieth Haider Mahdi , Munahi Basil Sh. , Mohammad Haider M. 
Published: April 2024

Abstract
Improving corrosion resistance in alloys made of stainless steel is an important innovation on the petroleum trade. The effect of heat treatments (HT) and cold working on the corrosion behaviour, surface hardness, and microstructure of 316 stainless steel was investigated experimentally. The corrosion environment is seawater and crude oil. The corrosion rates (CRs) were obtained using the mean loss of weight approach, which was then optimised using the Taguchi method. The specimens used in this study are made of 316 stainless steel rod, which is first annealed to obtain the qualities of the raw material before being put through a tensile test to assess the mechanical characteristics of the metal. After cold working, the hardness test, the corrosion test utilising the lost weight method, and the microstructure test are all carried out. By performing these tests, the metal show excellent mechanical properties such as yield stress, tensile stress, and hardness; in the corrosion test, the raw metal show higher resistance in both seawater and crude oil, while in cold working and HT with cold working, samples show higher corrosion The HT samples had the lowest corrosion resistance as the cold working percentage increased. In this work, the input parameters such as ultimate corrosion media, HT and cold work (CW) are optimised utilising a multiple objective optimisation approach that uses weighted grey relational analysis. Two objectives, that are CR and Hardness (H), are simultaneously optimised. We suggested a quantitative approach to establish the weight factors of various responses for grey relational analysis called weighted grey relational analysis. The optimum input parameters were determined using weighted grey relational analysis, and the outcomes showed that HT is the most relevant parameter. Cold working has been observed in association with stress-related twinning and austenite phase deformation, resulting in fast grain splitting and the production of a microstructure that resembles a ribbon composed of austenite and ferrite.
Effect of ground tyre rubber content on self-healing properties of natural rubber composites
Authors: Masraff Mimi Syahira , Othman Nadras , Musa Muhamad Sharan , Tran Dai Lam , Shuib Raa Khimi 
Published: April 2024

Abstract
In this investigation, we study the influence of the loading of ground tyre rubber (GTR), referred to as rubber dust 40 mesh (RD40), on the intrinsic self-healing natural rubber (NR) based on metal-thiolate ionic networks. The loading of RD40 particles was varied at 10, 20, and 30 phr to assess the optimum amount for interfacial bonding, mechanical and dynamic properties, and healing efficiency. The quantitative measurement of metal-thiolate ion networks and covalent crosslinks was assessed through swelling tests. The effects of RD40 loading on the dynamic mechanical properties and morphological characteristics were also investigated. Tensile properties of the rubbers before and after healing were measured using universal testing tester to obtain healing efficiency of the materials. The results showed that the developed materials have the ability to autonomously repair themselves at room temperature without the need for manual intervention. The results also revealed the tensile strength and elongation at break of self-healing NRs filled with 10 phr of RD40 were recovered 92 % and 93 %, respectively. The findings demonstrated the benefits of utilizing GTR as an effective sustainable filler and advanced the understanding of self-healing strategies and the interaction between ground tyre rubber and rubber matrices.
Uranium concentrations and its isotopes in baby food of Iraq
Authors: Taher Farqad Abbas , Abojassim Ali Abid 
Published: April 2024

Abstract
This study determines uranium concentrations and isotopes (238U, 235U, and 234U) in baby food samples collected from Iraqi markets using solid-state nuclear track detector technical (CR-39). Also, some radiological hazard parameters such as annual committed effective dose (E
U) and risk of an excess cancer fatality per million persons (RECFPMP) for the same study samples were calculated using theoretical equations. The samples in the present study were classified into three varieties: cereals and cereal products, vegetables and fruits, and biscuits. The results show that the average uranium concentration (mg/kg or ppm) values in cereals and cereal products, vegetables and fruits, and biscuits were 0.71 ± 0.01, 0.81 ± 0.04, and 0.72 ± 0.031, respectively. At the same time, the average values of 238U, 235U, and 234U in all samples of the present study were 9.08 ±0.17 Bq/kg, 0.42 ± 0.0081 Bq/kg, and 9.33 ± 0.18 Bq/kg, respectively. The total average of E
U (mSv/y) due to all uranium isotopes (238U, 235U, and 234U) in cereals and cereal products, vegetables and fruits, and biscuits were 0.042 ± 0.0006, 0.039 ± 0.001, and 0.034 ± 0.001, respectively. Moreover, it was found that the average values of RECFPMP were 0.159 ± 0.002 in cereals and cereal products samples, 0.154 ± 0.007 in vegetables and fruits samples, and 0.130 ± 0.005 in biscuits samples. Uranium concentrations and the total annual committed effective dose in all baby food samples comply with the worldwide limits approved by UNSCEAR, which state safe limitations (1.7 mg/kg) and (0.32 mSv/y), respectively. So, one may conclude that there is no danger of uranium concentrations in the case of baby consumption.
Micellar extracts obtained from Bistortae rhizoma, Fraxinus excelsior, and Romex crispus as components of hair shampoos
Authors: Zięba Małgorzata , Czerwonka Dominik , Ruszkowska Millena 
Published: April 2024

Abstract
The aim of the present study was to evaluate the potential applications of micellar extracts derived from Bistortae rhizoma, Fraxinus excelsior, and Romex crispus as components of hair shampoos and to examine the impact of these micellar extracts on the specific properties of the formulated cosmetics. The antioxidant activity, polyphenol content, and vitamin C content of the plant materials selected for the study were assessed. In addition, particle size analysis was performed for the obtained micellar extracts. The shampoos prepared on the basis of original formulations were evaluated for irritation potential, viscosity, foam stability index, and color. The plants evaluated in the study exhibited a high level of antioxidant activity, and the derived extracts were found to contain micellar aggregates. The application of the extracts was shown to reduce the skin irritation potential of the shampoos and reduce their viscosity. In addition, the formulated shampoos were characterized by a high foam stability index. Substantial variations in the color of the cosmetics were observed upon the introduction of the micellar extracts into the formulations.
“But his sense of justice turned him into a brigand and a murderer.” On Gunther Teubner’s “Self-subversive Justice: Contingency or Transcendence Formula of Law?”
Authors: Nobles Richard , Schiff David 
Published: April 2024

Abstract
Teubner’s article on self-subversive justice is an inspiring example of the way in which he tries to move forward Luhmann’s sociological endeavour of understanding law in terms of how it understands itself. Moving Luhmann’s autopoietic systems theory forward is something that Teubner significantly does in many of his writings. Here he contrasts various social and legal philosophical accounts with a potential sociological account of justice that utilises the contrasting versions of both Luhmann’s autopoietic systems theory and Derrida’s deconstruction theory. To appreciate how justice operates self-subversively is to appreciate how law cannot avoid striving to overcome itself, and how justice both in its many universal and alterity forms enables this. Teubner gets close to marrying not only Luhmann and Derrida, but also sociological theory and literary or poetic theory; also marrying judicial creativity with that of other creative arts. Law constantly looks to justice within its own practices, but at the same time beyond those practices and thereby challengingly confronting itself and its search for justice in doing so.
The Impact of an 8-Week Resisted Sprint Training Program on Ice Skating Performance in Male Youth Ice Hockey Players
Authors: Dietze-Hermosa Martin S. , Montalvo Samuel , Gonzalez Matthew P. , Dorgo Sandor 
Published: April 2024

Abstract
Dietze-Hermosa, MS, Montalvo, S, Gonzalez, MP, and Dorgo, S. The impact of an 8-week, resisted, sprint training program on ice skating performance in male youth ice hockey players. J Strength Cond Res 38(5): 957–965, 2024—The purposes of this randomized control study were to (a) compare the effects of an on-ice versus an overground resisted sprint training intervention and a control condition and (b) identify changes in ice skating kinematics and kinetics after training intervention participation. Twenty-four youth ice hockey players were randomly allocated into 3 groups: (a) on-ice resisted sprint training (on-ice RST); (b) overground resisted sprint training (overground RST); and (c) body weight resistance training (control). During the 8-week intervention, the 2 RST groups engaged in sled towing methods, whereas the control group engaged in a body weight resistance training program twice a week. A series of individual, repeated-measures analysis of variances with post hoc pairwise comparisons were conducted for variables of interest. An interaction effect was noted for ice skating s-cornering agility drill completion time (p = 0.01; η

p

2 = 0.36), ice skating 30-m top speed completion time (p = 0.04; η

p

2 = 0.27), step length (p = 0.04; η

p

2 = 0.26), and knee angle at touchdown (p = 0.03; η

p

2 = 0.30). The on-ice RST group displayed superior improvements across ice skating tests compared with the control group. Data show that on-ice RST has the greatest transfer effect to ice skating metrics; however, improvements in certain ice skating metrics can be observed with overground training also.
Large language models and their possible uses in law
Authors: Homoki Péter , Ződi Zsolt 
Published: April 2024

AbstractThe paper explores the potential applications of Large Language Models (LLMs) like ChatGPT in the legal field, focusing on how they can enhance access to law. We begin by elucidating the fundamental workings of LLMs and their current and future general applications. The core of our study predicts the utilization of LLMs in various legal domains, especially where tasks like text retrieval, generation, labeling, and classification are prevalent. We argue that tools like ChatGPT could play a pivotal role in these areas. Additionally, we discuss the limitations and customization requirements of LLMs, particularly for legal uses. An experiment conducted by one of the authors, involving a tailored version of GPT for small law firms, serves as a practical example, but building on this, the paper also proposes ways in which LLM-based applications could democratize access to justice, making legal assistance more accessible and efficient for the broader public. This study contributes to the understanding of the intersection between AI technology and legal services, highlighting both the opportunities and challenges in this field.
Las siete plagas, entre realidad y ficción
Authors: Torres Kevin E. 
Published: April 2024

La sección de las siete plagas abarca Ap 15 y 16, con dos bloques marcados: una visión introductoria del santuario y las siete plagas. La narrativa de la ejecución de las 7 plagas tiene estructurada cada plaga en tres partes, las cuales son: destinatario, plaga e información adicional. Así también, las secuencias dentro de la sección de las siete plagas indican una destrucción generalizada de la tierra. Estos juicios afectan de manera sumativa a dos grupos: los seguidores de la bestia y el gobierno de la bestia. Finalmente, la visión de las siete plagas está lleno de elementos literales como simbólicos; es importante para la interpretación de esta sección identificar y clasificar estos elementos.
Macroinvertebrados bentónicos como bioindicadores de calidad en el Lago Titicaca: Bahía Interior de Puno
Authors: SALAMANCA COAQUIRA SANDRA LINDAURA 
Published: April 2024

El objetivo del presente estudio fue determinar la calidad del agua de la Bahía Interior de Puno, sector oeste del Lago Titicaca, a partir de observaciones sobre la comunidad de macroinvertebrados bentónicos. Fue ejecutado con periodicidad mensual entre marzo y junio del 2012. Se establecieron nueve estaciones de muestreo en donde se extrajeron muestras de bentos con empleo de draga Ekman. Los índices analizados fueron Shannon-Weaver y Biological Monitoring Working Party Score System (BMWP). La estación con mayor biodiversidad fue la E-1 (Muelle, margen derecho), representada por 6577 individuos y 6 familias, seguida por la E-9 (frente, UNA Puno) con 5200 individuos y 4 familias. La estación E-4 (Bajo el terminal zonal) fue la menos diversa, con 178 individuos y 1 familia, seguida por la E-5 (Laguna de oxidación, izquierda) con 1110 individuos y 3 familias; en la estación de control E-6 (Control, aguas limpias) encontramos 3600 individuos y 2 familias, es la estación en la cual nunca se registraron las familias Chironomidae, Tubificidae, Planorbidae y Ostrácoda. Con el índice de Shannon-Weaver no se encontró diferencias entre estaciones y meses, obteniéndose valores de 0 a 1,3, calificadas como “poco diversa”. De acuerdo al índice biológico BMWP, la calidad del agua en el ámbito de estudio tuvo calificativos entre 2 y 28, “calidad crítica” y “calidad muy crítica” que significan “aguas muy contaminadas” y “aguas fuertemente contaminadas”. Los resultados ponen en evidencia el estado crítico de la calidad del agua en la Bahía Interior de Puno, siendo necesario buscar medidas que permitan su recuperación ambiental.
Palabras clave: contaminación, aguas negras, biodiversidad, fauna bentónica