bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prospective randomized double‐blind comparative study of topical acetyl zingerone with tetrahexyldecyl ascorbate versus tetrahexyldecyl ascorbate alone on facial photoaging
Authors: Afzal Nasima , Nguyen Nhi , Min Mildred , Egli Caitlin , Afzal Shabnam , Chaudhuri Ratan K. , Burney Waqas A. , Sivamani Raja K. 
Published: March 2024

AbstractBackgroundTetrahexydecyl ascorbate (THDA) is a lipophilic precursor to ascorbic acid that may be stabilized by acetyl zingerone (AZ). Studies have shown that the topical application of THDA may have photoprotective effects. Similarly, AZ has been shown to mitigate oxidative and inflammatory stress, thereby improving the appearance of photoaging.AimsTo examine the effects of THDA and AZ (THDA‐AZ) on skin photoaging compared to THDA alone.Patients/MethodsIn this double‐blind, randomized controlled trial, healthy individuals aged 30 to 65 were included and 44 participants were randomized to receive either THDA‐AZ (THDA 5% + AZ 1%) or THDA only (THDA 5%) for 8 weeks. Facial photographs were taken at 0, 4, and 8 weeks to analyze wrinkle severity, pigment intensity, and redness intensity. A skin colorimeter was used to assess infraorbital pigmentation and erythema. Self‐perception of skin and tolerability were assessed through questionnaires.ResultsAverage wrinkle severity was significantly decreased in the THDA‐AZ group at Weeks 4 and 8 by 0.75% (p = 0.023) and 3.72% (p = 0.048), respectively, compared to the THDA group where wrinkle severity at Weeks 4 and 8 was increased by 7.88% and 4.48%, respectively. Facial pigment intensity was significantly decreased in the THDA‐AZ group by 4.10% (p = 0.0002) at Week 8 compared to a 0.69% decrease in the THDA group. Facial redness intensity was decreased in the THDA‐AZ group at Weeks 4 and 8 by 3.73% (p = 0.0162) and 14.25% (p = 0.045), respectively, compared to the THDA group where at Weeks 4 and 8 erythema increased by 27.5% and 8.34%, respectively. There were no significant differences in either group for infraorbital pigmentation or erythema.ConclusionsDaily use of combined THDA and AZ may improve facial wrinkle severity, pigment intensity, and erythema to a greater extent than THDA. While THDA alone increases facial wrinkle severity and erythema, the addition of AZ reduces both.
Prenatal insomnia disorder may predict concurrent and postpartum psychopathology: A longitudinal study
Authors: Palagini Laura , Miniati Mario , Driul Lorenza , Colizzi Marco , Comacchio Carla , Gemignani Angelo , Balestrieri Matteo ,   Insomnia in Pregnancy Research Group (IPRG)
Published: March 2024

SummaryWhile insomnia symptoms may be a risk factor for mental disturbances, few studies evaluated “Insomnia Disorder” and its relationship with perinatal psychopathology. Pregnant women were recruited during their last routine assessment before being hospitalized for delivery during the 3rd trimester at the Gynaecological Unit of the University Hospital of Ferrara and Udine, Italy, from January 2022 to January 2023. Our assessment included baseline evaluation (T0), and evaluations at 1 month (T1) and 3 months (T2) in the postpartum period, with specific questionnaires for insomnia disorder, such as Sleep Condition Indicator, mood and anxiety symptoms and psychosocial functioning, such as Edinburgh Postnatal Depression Scale, Mood Disorder Questionnaire, State–Trait Anxiety Inventory, Work and Social Adjustment Scale. At T0, 181 pregnant women were included. Insomnia disorder affected 22.3% at T0, 23.5% at T1 and 16.2% at T2. Women with insomnia disorder at baseline were significantly more affected by concurrent anxiety and depressive symptoms, had higher bipolar diathesis and poorer psychosocial functioning in the perinatal period. Prenatal insomnia disorder predicted anxiety (T0: odds ratio 4.44, p << 0.001; T1: odds ratio 4.009, p = 0.042) and depressive symptoms (T0: odds ratio 2.66, p = 0.015; T1: odds ratio 11.20, p = 0.001; T2: odds ratio 12.50 p = 0.049) in both the prenatal and postnatal period. It also predicted poor psychosocial function during the prenatal (odds ratio 3.55, p = 0.003) and postpartum periods (T1: odds ratio 2.33, p = 0.004). Insomnia disorder is emerging as an important prenatal factor that may contribute to concurrent and postpartum psychopathology.
Court‐hoarding: Another method of gaming judicial turnover
Authors: Leisure Patrick , Kosař David 
Published: March 2024

AbstractWhile a slew of recent scholarship has examined the phenomenon of executive overstay, there is little talk about the more complex and equally vexing phenomena of judicial overstay. This article begins to examine the many layers and complexities of judicial overstay by exploring whether the political branches ever seek to prolong abusively the time in office of loyal judges, and if so, by what mechanisms. Illustrating this is not merely a theoretical practice, we label such a phenomenon court‐hoarding, and consider it a subset of the broader category of judicial overstay. Our contribution is two‐fold. First, we argue that while court‐hoarding is a somewhat risky and less‐known governance tactic that is likely to occur only when certain conditions are fulfilled, the potential benefits of court‐hoarding for power consolidation and institutional monopoly power are profound. Second, we contribute to the emerging literature on judicial tenure. More specifically, we add conceptual utility to thinking about judicial tenure—and its abuse—by describing a three‐layer model of court‐hoarding, consisting of a core, a mid‐layer, and a periphery, which correspond to three broad categories of influencing judicial tenure across time and space.
Impact of demographic factors, comorbidities, and co‐medication on progression and survival in a large Chinese ALS cohort
Authors: Hu Nan , Zhang Lei , Shen Dongchao , Yang Xunzhe , Liu Mingsheng , Cui Liying 
Published: March 2024

AbstractObjectiveTo clarify the impact of specific risk/protective factors on the disease progression and survival in a large population of Chinese sporadic ALS (sALS) patients.MethodsWe investigated a cohort of 937 sALS patients prospectively. Uni‐ and multivariate regression analysis were performed to analyze the influence of demographic factors, comorbidities and medication on the progression and survival of ALS.ResultsOur results showed younger age of onset (p < 0.05), long diagnostic delay (p < 0.001) and intake of riluzole (p < 0.001) were significantly related to low progression rate and long survival time. History of smoking (p < 0.05) and bulbar onset (p < 0.001) were risk factors for rapid progression and poor prognosis. Baseline ALSFRS‐R score (p < 0.001) and total MRC score (p < 0.05) were positively related to mean survival time of included patients. Neither comorbidities nor intake of antihypertensive drugs, antidiabetics, and statins as dependent variables showed considerable influence on ALS progression or survival.ConclusionOur study revealed early onset and long diagnostic delay were indicators of slow progression and long survival. Smoking and bulbar onset were risk factors for shorter survival times and abstaining from smoking was beneficial to patients with ALS in improving median survival time. Long‐term intake of riluzole should be recommended for affordable patients.
Cryoballoon pulmonary vein isolation versus radiofrequency ablation of the pulmonary veins and left atrial posterior wall: Patient‐reported outcomes
Authors: Farwati Medhat , Braghieri Lorenzo , Abdulhai Farah A. , Dabbagh Marwan , Alkhalaileh Firas A. , Younis Arwa , Tabaja Chadi , Farwati Amr , Amin Mustapha , Santangeli Pasquale , Nakagawa Hiroshi , Saliba Walid I. , Kanj Mohamed , Callahan Thomas D. , Bhargava Mandeep , Baranowski Bryan , Rickard John , Sroubek Jakub , Lee Justin , Tchou Patrick J. , Wazni Oussama M. , Hussein Ayman A. 
Published: March 2024

AbstractBackgroundData are lacking on patient‐reported outcomes (PRO) following cryoballoon ablation (CBA) versus radiofrequency ablation (RFA). We sought to evaluate QoL and clinical outcomes of cryoballoon pulmonary vein isolation only (CRYO‐PVI‐ONLY) versus RFA with PVI and posterior wall isolation (RF‐PVI+PWI) in a large prospective PRO registry.MethodsPatients who underwent AF ablation (2013–2016) at our institution were enrolled in an automated, prospectively maintained PRO registry. CRYO‐PVI‐ONLY patients were matched (1:1) with RF‐PVI+PWI patients based on age, gender, and type of AF (paroxysmal vs. persistent). QoL and clinical outcomes were assessed using PRO surveys at baseline and at 1‐year. The atrial fibrillation symptom severity scale (AFSSS) was the measure for QoL. Additionally, we assessed patient‐reported clinical improvement, arrhythmia recurrence, and AF burden (as indicated by AF frequency and duration scores).ResultsA total of 296 patients were included (148 in each group, 72% paroxysmal). By PRO, a significant improvement in QoL was observed in the overall study population and was comparable between CRYO‐PVI‐ONLY and RF‐PVI+PWI (baseline median AFSSS of 11.5 and 11; reduced to 2 and 4 at 1 year, respectively; p = 0.44). Similarly, the proportion of patients who reported improvement in their overall QoL and AF related symptoms was high and similar between the study groups [92% (CRYO‐PVI‐ONLY) vs. 92.8% (RF‐PVI+PWI); p = 0.88]. Arrhythmia recurrence was significantly more common in the CRYO‐PVI‐ONLY group (39.7%) compared to RF‐PVI+PWI (27.7 %); p = 0.03. Comparable results were observed in paroxysmal and persistent AF.ConclusionCRYO‐PVI‐ONLY and RF‐PVI+PWI resulted in comparable improvements in patient reported outcomes including QoL and AF burden; with RF‐PVI+PWI being more effective at reducing recurrences.
Iatrogenic vertebral artery injury during catheter ablation treated using coil embolization
Authors: Oshima Tsukasa , Yamagata Kenichiro , Shimizu Yu , Koizumi Satoshi , Fujiu Katsuhito , Komuro Issei 
Published: March 2024

AbstractThe internal jugular vein (IJV) is occasionally used for blood access during catheter ablation. Additionally, accidental injury of the vertebral artery during an IJV puncture is a rare complication that can result in catastrophic events, such as death. However, vascular access complications cannot be completely prevented despite the introduction of ultrasound‐guided punctures. Here, we present a case of a patient with symptomatic paroxysmal atrial fibrillation that required catheter ablation.
Addressing diversity, equity, and inclusion: A response of professional nursing organizations to the future of nursing: 2020–2030 recommendations
Authors: Campbell Lisa A. , Kelly Patricia J. , Kneipp Shawn M. 
Published: March 2024

AbstractOne way in which professional nursing organizations have chosen to address the social determinants of health (SDoH) is through policy work focused on diversity, health equity and anti‐racism activities. The recent report, Future of Nursing 2020–2030: Charting a Path to Achieve Health Equity (FON 2020–2030), calls on professional nursing organizations and/or nursing coalitions to focus on addressing the SDoH to mitigate health inequities, including a focus on addressing racism and promoting practices to ensure the diversity of the nursing workforce. While these recommendations highlight issues of high importance to nursing and the broader society, they assume that professional nursing organizations or coalitions have not been sufficiently engaged in this work to date. Our goal was to better understand the current and/or ongoing activities of professional nursing organizations around their anti‐racism work of diversity, health equity, and inclusion (DEI) activities recommended in the FON 2020–2030 report. To address this goal, we conducted a needs assessment of professional nursing organizations to document their DEI activities and the timing of these activities relevant to the recommendations in the report. The 26 responding organizations indicated they had been engaged in work addressing DEI issues for periods ranging from 4 months to 51 years. Minimal funding was the major barrier to advancing this work. Creating a vigorous shared DEI agenda across the profession, as suggested in the FON 2020–2030 report, will require input from nurses across the profession, as well as identification of resources to support this critical endeavor.
The integration of GIS location‐based APIs and urban growth modeling for improved geographic access to hospital services
Authors: Sejati Anang Wahyu , Putri Savira Nur Afifah Kusuma , Buchori Imam , de Vries Walter Timo , Barbarossa Ghiffari , Margarena Candra , Bramiana Chely Novia 
Published: March 2024

AbstractThis article aims to present an integration model of GIS with open data sourced from application programming interface (API) as a solution for the location set covering problem (LSCP) with an urban land dynamics model. The development of GIS which is increasingly advanced makes traditional GIS transition in the open data era to become more modern. One of the benefits is to help urban planners in determining the allocation of health facilities such as hospitals. This research takes the case of hospital service coverage during emergencies, especially during the COVID‐19 extraordinary event in Metropolitan Semarang, Indonesia. In addition to utilizing API‐base Location, the model process also uses a Cellular Automata‐based land use prediction model. Thus, the facility location plan not only considers service coverage but also land use growth which is a reflection of population growth. To analyze the problem of inequity of hospital services, this research combined the location‐based APIs‐based service area model with the urban growth model to evaluate the existing condition and predict the future of hospital service demand. It also uses the emergency standard with a maximum service distance of 1500 m and a maximum travel time of 7 min. The model confirmed that there are still critical spots not served by hospitals in Semarang City. According to the concept of health and place, it is essential to recommend adding two hospitals in unserved areas so that services are more evenly distributed in the future, especially in emergencies.
Loss of daylength sensitivity by splice site mutation in Cannabis pseudo‐response regulator
Authors: Leckie Keegan M. , Sawler Jason , Kapos Paul , MacKenzie John O. , Giles Ingrid , Baynes Katherine , Lo Jessica , Baute Gregory J. , Celedon Jose M. 
Published: March 2024

SUMMARYPhotoperiod insensitivity (auto‐flowering) in drug‐type Cannabis sativa circumvents the need for short day (SD) flowering requirements making outdoor cultivation in high latitudes possible. However, the benefits of photoperiod insensitivity are counterbalanced by low cannabinoid content and poor flower quality in auto‐flowering genotypes. Despite recent studies in cannabis flowering, a mechanistic understanding of photoperiod insensitivity is still lacking. We used a combination of genome‐wide association study and genetic fine‐mapping to identify the genetic cause of auto‐flowering in cannabis. We then used gene expression analyses and transient transformation assays to characterize flowering time control. Herein, we identify a splice site mutation within circadian clock gene PSEUDO‐RESPONSE REGULATOR 37 (CsPRR37) in auto‐flowering cannabis. We show that CsPRR37 represses FT expression and its circadian oscillations transition to a less repressive state during SD as compared to long days (LD). We identify several key circadian clock genes whose expression is altered in auto‐flowering cannabis, particularly under non‐inductive LD. Research into the pervasiveness of this mutation and others affecting flowering time will help elucidate cannabis domestication history and advance cannabis breeding toward a more sustainable outdoor cultivation system.
HSP70A promotes the photosynthetic activity of marine diatom Phaeodactylum tricornutum under high temperature
Authors: Yang Wenting , Gao Shan , Bao Mengjiao , Li Xin , Liu Zhiyuan , Wang Guangce 
Published: March 2024

SUMMARYWith global climate change, the high‐temperature environment has severely impacted the community structure and phenotype of marine diatoms. Phaeodactylum tricornutum, a model species of marine diatom, is sensitive to high temperature, which grow slowly under high temperature. However, the regulatory mechanism of P. tricornutum in response to high‐temperature is still unclear. In this study, we found that the expression level of the HSP70A in the wild type (WT) increased 28 times when exposed to high temperature (26°C) for 1 h, indicating that HSP70A plays a role in high temperature in P. tricornutum. Furthermore, overexpression and interference of HSP70A have great impact on the exponential growth phase of P. tricornutum under 26°C. Moreover, the results of Co‐immunoprecipitation (Co‐IP) suggested that HSP70A potentially involved in the correct folding of the photosynthetic system‐related proteins (D1/D2), preventing aggregation. The photosynthetic activity results demonstrated that overexpression of HSP70A improves non‐photochemical quenching (NPQ) activity under high‐temperature stress. These results reveal that HSP70A regulates the photosynthetic activity of P. tricornutum under high temperatures. This study not only helps us to understand the photosynthetic activity of marine diatoms to high temperature but also provides a molecular mechanism for HSP70A in P. tricornutum under high‐temperature stress.
Determining the impact of current Canadian stem cell registry policy on donor availability via dynamic registry simulation
Authors: Blake John T. , Ganz Kathy , Seftel Matthew , Allan David 
Published: March 2024

AbstractBackground and ObjectivesWhen a haematopoietic stem cell registry size is constrained by limits on recruiting, as in Canada, identifying the right person to recruit is a critical determinant of effectiveness. The aim of this study was to evaluate the impact of changes to donor recruitment effort, within ethnic groups, on the matching effectiveness of the Canadian registry as it evolves over time.Materials and MethodsSimulation methods are applied to create a cohort of donor recruits and patients over a 10‐year time horizon. New recruits are added to the registry each year, while some existing donors ‘age‐out’ upon reaching their 36th birthday. In a similar fashion, simulated patient lists are created. At the end of each simulated year, simulated patients are matched against the simulated registry.ResultsThere are increased matches in non‐White populations when diverse registrants are preferentially recruited, but there are larger decreases in the number of matches for Caucasian patients. Additionally, ethnic communities that have limited registrants in the Canadian registry in 2021 do not benefit from increased recruiting efforts as much as communities with a larger initial number of registrants.ConclusionPreferentially recruiting from non‐Caucasian populations reduces the number of matches from Canadian sources because increases in non‐Caucasian populations will not fully counterbalance decreases to Caucasian patient matches. Nevertheless, more than 80% of all matches are for Caucasian patients, regardless of the donor recruiting effort within ethnic groups.
Long‐term outcome of permanent tracheostomy management in two brachycephalic dogs using a commercial and a three‐dimensional‐printed silicone stent
Authors: Janssen Janina N. , Gradner Gabriele M. , Liehmann Lea 
Published: March 2024

AbstractObjectiveTo report the long‐term outcome of utilization of a silicone stent to support the management of a permanent tracheostomy.Study designShort case series.AnimalsTwo client‐owned brachycephalic dogs.MethodsTwo brachycephalic dogs with stage III laryngeal collapse underwent permanent tracheostomy. After the tracheostomy had healed, a silicone stent was inserted to support the stoma and facilitate home care. One dog wore a commercially available silicone stent for the follow‐up period of 2 years. For the dog in Case 2, a 3D‐printed, medical‐grade silicone stent with an increased length was designed, as the dog had developed skin sores from the commercial device.ResultsBoth dogs tolerated the silicone stent well. Stent care was managed by the owners without need for assistance. They reported that the silicone stent facilitated cleaning of the stoma surroundings and that they felt an increased confidence in airway patency, as the device prevented the tracheal stoma from collapsing. In Case 1, tracheoscopy 1 year after first stent insertion revealed minimal visible changes to the tracheal stoma. In Case 2, the 3D printed silicone stent led to a remission of skin sores and the dog wore the device comfortably until succumbing to an unrelated disease 13 months later.ConclusionThe insertion of a silicone stent is a simple and cost‐effective method to improve home care of dogs with permanent tracheostomy. Larger dogs, as in Case 2, may benefit from custom‐designed 3D‐printed stents.
Outcomes by
Candida
spp. in the ReSTORE Phase 3 trial of rezafungin versus caspofungin for candidemia and/or invasive candidiasis
Authors: Locke Jeffrey B. , Pillar Chris M. , Castanheira Mariana , Carvalhaes Cecilia G. , Andes David , Aram Jalal A. , Andrzejewski Christina , Bartizal Ken , Das Anita F. , Sandison Taylor , Thompson George R. , Pappas Peter G. 
Published: March 2024

ABSTRACT

Rezafungin is a long-acting, intravenously administered echinocandin for the treatment of candidemia and invasive candidiasis (IC). Non-inferiority of rezafungin vs caspofungin for the treatment of adults with candidemia and/or IC was demonstrated in the Phase 3 ReSTORE study based on the primary endpoints of day 14 global cure and 30-day all-cause mortality. Here, an analysis of ReSTORE data evaluating efficacy outcomes by baseline
Candida
species is described. Susceptibility testing was performed for
Candida
species using the Clinical and Laboratory Standards Institute reference broth microdilution method. There were 93 patients in the modified intent-to-treat population who received rezafungin; 94 received caspofungin. Baseline
Candida
species distribution was similar in the two treatment groups;
C. albicans
(occurring in 41.9% and 42.6% of patients in the rezafungin and caspofungin groups, respectively),
C. glabrata
(25.8% and 26.6%), and
C. tropicalis
(21.5% and 18.1%) were the most common pathogens. Rates of global cure and mycological eradication at day 14 and day 30 all-cause mortality by
Candida
species were comparable in the rezafungin and caspofungin treatment groups and did not appear to be impacted by minimal inhibitory concentration (MIC) values for either rezafungin or caspofungin. Two patients had baseline isolates with non-susceptible MIC values (both in the rezafungin group: one non-susceptible to rezafungin and one to caspofungin, classified as intermediate); both were candidemia-only patients in whom rezafungin treatment was successful based on the day 30 all-cause mortality endpoint. This analysis of ReSTORE demonstrated the efficacy of rezafungin for candidemia and IC in patients infected with a variety of
Candida
species.