bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Freestanding, Dissolution‐ and Diffusion‐Limiting, Flexible Sulfur Electrode Enables High Specific Capacity at High Mass Loading
Authors: Guo Qianyi , Wang Chao , Shang Jian , Yang Yu , Xie Chuan , Luo Yufeng , Rong Mingming , Pei Yi , Gao Yuan , Zheng Zijian 
Published: March 2024

AbstractThe acquisition of stable and high‐areal‐capacity S cathodes over 10 mA h cm−2 is a critical and indispensable step to realize the high energy density configuration. However, increasing the areal capacity of S cathodes often deteriorates the specific capacity and stability due to the aggravated dissolution of S and diffusion of solvable polysulfides in the thick electrode. Herein, the design of a freestanding composite cathode that leverages 3D covalent binding sites and chemical adsorption environment to offer dissolution‐limiting and diffusion‐blocking functions of S species is reported. By employing this architecture, the coin cell exhibits excellent cycling stability and an exceptional specific capacity of 1444.3 mA h g−1 (13 mA h cm−2), and the pouch cell configuration manifests a noteworthy areal capacity exceeding 11 mA h cm−2. This performance is coupled with excellent flexibility, demonstrated through consecutive bending cycle tests, even at a sulfur loading of 9.00 mg cm−2. This study lays the foundation for the development of flexible Li–S batteries with increased loading capacities and exceptional performance.
Platinum Nanoparticles Regulated V2C MXene Nanoplatforms with NIR‐II Enhanced Nanozyme Effect for Photothermal and Chemodynamic Anti‐Infective Therapy
Authors: He Xiaojun , Lv Ya , Lin Yanling , Yu Hong , Zhang Yipiao , Tong Yuhua , Zhang Chunwu 
Published: March 2024

AbstractGiven the challenge of multidrug resistance in antibiotics, non‐antibiotic–dependent antibacterial strategies show promise for anti‐infective therapy. V2C MXene‐based nanomaterials have demonstrated strong biocompatibility and photothermal conversion efficiency (PCE) for photothermal therapy (PTT). However, the limitation of V2C MXene's laser irradiation to the near‐infrared region I (NIR‐I) restricts tissue penetration, making it difficult to achieve complete bacterial eradication with single‐effect therapeutic strategies. To address this, Pt nanoparticles (Pt NPs) are attached to V2C, forming artificial nanoplatforms (Pt@V2C). Pt@V2C exhibits enhanced PCE (59.6%) and a longer irradiation laser (NIR‐II) due to the surface plasmon resonance effect of Pt NPs and V2C. Notably, Pt@V2C displays dual enzyme‐like activity with chemodynamic therapy (CDT) and NIR‐II enhanced dual enzyme‐like activity. The biocatalytic mechanism of Pt@V2C is elucidated using density functional theory. In an in vivo animal model, Pt@V2C effectively eliminates methicillin‐resistant Staphylococcus aureus from deep‐seated tissues in subcutaneous abscesses and bacterial keratitis environments, accelerating abscess resolution and promoting wound and cornea healing through the synergistic effects of PTT/CDT. Transcriptomic analysis reveals that Pt@V2C targets inflammatory pathways, providing insight into its therapeutic mechanism. This study presents a promising therapeutic approach involving hyperthermia‐amplified biocatalysis with Pt NPs and MXene nanocomposites.
Dendritic Polymer‐Based Nanomedicines Remodel the Tumor Stroma: Improve Drug Penetration and Enhance Antitumor Immune Response
Authors: Zhang Yuxin , Fang Zaixiang , Pan Dayi , Li Yunkun , Zhou Jie , Chen Hongying , Li Zhiqian , Zhu Mengli , Li Cong , Qin Liwen , Ren Xiangyi , Gong Qiyong , Luo Kui 
Published: March 2024

AbstractThe dense extracellular matrix (ECM) in solid tumors, contributed by cancer‐associated fibroblasts (CAFs), hinders penetration of drugs and diminishes their therapeutic outcomes. A sequential treatment strategy of remodeling the ECM via a CAF modifier (dasatinib, DAS) is proposed to promote penetration of an immunogenic cell death (ICD) inducer (epirubicin, Epi) via apoptotic vesicles, ultimately enhancing the treatment efficacy against breast cancer. Dendritic poly(oligo(ethylene glycol) methyl ether methacrylate) (POEGMA)‐based nanomedicines (poly[OEGMA‐Dendron(G2)‐Gly‐Phe‐Leu‐Gly‐DAS] (P‐DAS) and poly[OEGMA‐Dendron(G2)‐hydrazone‐Epi] (P‐Epi)) are developed for sequential delivery of DAS and Epi, respectively. P‐DAS reprograms CAFs to reduce collagen by downregulating collagen anabolism and energy metabolism, thereby reducing the ECM deposition. The regulated ECM can enhance tumor penetration of P‐Epi to strengthen its ICD effect, leading to an amplified antitumor immune response. In breast cancer‐bearing mice, this approach alleviates the ECM barrier, resulting in reduced tumor burden and increased cytotoxic T lymphocyte infiltration, and more encouragingly, synergizes effectively with anti‐programmed cell death 1 (PD‐1) therapy, significantly inhibiting tumor growth and preventing lung metastasis. Furthermore, systemic toxicity is barely detectable after sequential treatment with P‐DAS and P‐Epi. This approach opens a new avenue for treating desmoplastic tumors by metabolically targeting CAFs to overcome the ECM barrier.
Operando Combined SAXS/XRD/XAFS Measurements of Lithium Conversion Battery
Authors: Takabayashi Yasuhiro , Kimura Koji , Miyazaki Takeshi , Yoshii Kazuki , Sakaebe Hikari , Shikano Masahiro , Takeichi Nobuhiko , Nakatani Tomotaka , Fujinami So , Kiuchi Hisao , Katayama Misaki , Hirano Tatsumi , Hayashi Koichi 
Published: March 2024

AbstractMany chemical reactions are accompanied by concerted phenomena, such as variance transition, structural changes, and particle formation. Various measurement techniques are employed to understand the whole picture of such concerted phenomena. A combination of small‐angle X‐ray scattering (SAXS), X‐ray diffraction (XRD), and X‐ray absorption fine structure (XAFS) is useful for studying concerted phenomena that occur, for example, inside rechargeable batteries. This combination can cover large lengths from 1 Å to several hundred nm. Operando measurements using this combination of methods can follow reactions during the charging and discharging of a rechargeable battery in a single experimental run. Fixed‐exit optics enable irradiation at the same point in a wide energy range. By employing 2D detectors for XRD and SAXS and using a quick XAFS technique, one can make the interval of each measurement sufficiently short to track various phenomena during charging and discharging. Here, an application of the system for alternating SAXS/XRD/XAFS measurements constructed in BL28XU, SPring‐8, Japan to the study of rechargeable batteries, is presented.
A Lightweight YOLO Object Detection Algorithm Based on Bidirectional Multi‐Scale Feature Enhancement
Authors: Liu Qunpo , Zhang Jingwen , Zhang Zhuoran , Bu Xuhui , Hanajima Naohiko 
Published: March 2024

AbstractThis paper proposes a lightweight YOLO object detection algorithm based on bidirectional multi‐scale feature enhancement. The problem is that the original YOLOv5 algorithm does not make full use of the relationship between the feature layers, resulting in the loss of target semantic information and a large number of parameters. First, a bidirectional multi‐scale feature‐enhanced weighted fusion backbone network is constructed to extract target features repeatedly. It enhances the fusion ability of shallow detail features and high‐level semantic information to capture richer multi‐scale semantic information. Second, the NCA attention module is built and integrated into the feature fusion network to enhance the critical characteristics of the target region. Finally, the Ghost module is used instead of the convolutional blocks in the original network to lighten the model while reducing the network complexity and training difficulty. Experimental results show that the improved YOLOv5 algorithm achieves 78.8% mAP@0.5 for the PASCAL VOC2012 dataset, which is 1.5% higher than the original algorithm, at 62.5 FPS. The number of parameters is also reduced by 43.6%. The mAP@0.5 on the self‐made metal foreign object dataset reached 98.4%, at 58.8 FPS, which can meet the requirements of end‐device deployment and real‐time detection.
Mg‐MOF‐74 Derived Defective Framework for Hydrogen Storage at Above‐Ambient Temperature Assisted by Pt Catalyst
Authors: Liu Shiyuan , Zhang Yue , Zhu Fangzhou , Liu Jieyuan , Wan Xin , Liu Ruonan , Liu Xiaofang , Shang Jia‐Xiang , Yu Ronghai , Feng Qiang , Wang Zili , Shui Jianglan 
Published: March 2024

AbstractMetal–organic frameworks (MOFs) are promising candidates for room‐temperature hydrogen storage materials after modification, thanks to their ability to chemisorb hydrogen. However, the hydrogen adsorption strength of these modified MOFs remains insufficient to meet the capacity and safety requirements of hydrogen storage systems. To address this challenge, a highly defective framework material known as de‐MgMOF is prepared by gently annealing Mg‐MOF‐74. This material retains some of the crystal properties of the original Mg‐MOF‐74 and exhibits exceptional hydrogen storage capacity at above‐ambient temperatures. The MgO5 knots around linker vacancies in de‐MgMOF can adsorb a significant amount of dissociated and nondissociated hydrogen, with adsorption enthalpies ranging from −22.7 to −43.6 kJ mol−1, indicating a strong chemisorption interaction. By leveraging a spillover catalyst of Pt, the material achieves a reversible hydrogen storage capacity of 2.55 wt.% at 160 °C and 81 bar. Additionally, this material offers rapid hydrogen uptake/release, stable cycling, and convenient storage capabilities. A comprehensive techno‐economic analysis demonstrates that this material outperforms many other hydrogen storage materials at the system level for on‐board applications.
Comparison of residual activity of pre‐emergence herbicides for control and seed production of multiple herbicide‐resistant Palmer amaranth in food‐grade white corn
Authors: Kaur Ramandeep , Chahal Parminder S. , Shi Yeyin , Lawrence Nevin C. , Knezevic Stevan Z. , Jhala Amit J. 
Published: March 2024

AbstractNebraska is the number‐one producer of food‐grade white corn (Zea mays L.) in the United States. Food‐grade white corn has not been genetically engineered; therefore, non‐selective herbicides such as glyphosate or glufosinate cannot be used. Multiple herbicide‐resistant (MHR) Palmer amaranth (Amaranthus palmeri S. Watson) populations have been reported in multiple counties in Nebraska, and their management is a challenge, particularly for white corn producers. The objectives of this study were to evaluate the residual activity of pre‐emergence (PRE) herbicides for acetolactate synthase inhibitor (halosulfuron‐methyl)/atrazine/glyphosate‐resistant Palmer amaranth control, density, biomass, seed production, and grain yield in food‐grade white corn. Field experiments were conducted during summer 2020 and 2021 in a grower's field infested with MHR Palmer amaranth near Carleton, NE. All the PRE herbicides resulted in similar control (>90%) 30 days after PRE application (DAPRE) apart from atrazine (64%). At 45 DAPRE, acetochlor/mesotrione, atrazine/bicyclopyrone/mesotrione/S‐metolachlor, and acetochlor/clopyralid/mesotrione controlled 90%–95% Palmer amaranth. Acetochlor/clopyralid/mesotrione and atrazine/bicyclopyrone/mesotrione/S‐metolachlor provided 96%–99% MHR Palmer amaranth control and reduced Palmer amaranth density and biomass to 2–4 plants m−2 and 5–12 g m−2 60 DAPRE. The highest corn yields of 12,139 kg ha−1 and 12,093 kg ha−1 in 2020 and 2021, respectively, were obtained with acetochlor/clopyralid/mesotrione. Palmer amaranth seed production was least with acetochlor/clopyralid/mesotrione (32,894 seeds m−2). Tested residual PRE herbicides did not show corn injury and were safe to use in food‐grade white corn. It is concluded that acetochlor/clopyralid/mesotrione and atrazine/bicyclopyone/mesotrione/S‐metolachlor are the best options for early season control of MHR Palmer amaranth in food‐grade white corn.
Association between oxidative balance score and inflammatory markers in middle‐aged and older Japanese people
Authors: Nanri Hinako , Hara Megumi , Nishida Yuichiro , Shimanoe Chisato , Higaki Yasuki , Tanaka Keitaro 
Published: March 2024

AbstractPurposeThis study aimed to investigate the association between oxidative balance score (OBS), wherein higher OBSs indicate lower oxidative stress, and high‐sensitivity C‐reactive protein (hs‐CRP), as well as inflammatory scores, in a large cohort of Japanese adults.MethodsIn total, 9703 individuals aged 40–69 years participated in a baseline survey of a population‐based cohort study in Saga, Japan (2005–2007). OBSs were calculated from 11 prooxidant and antioxidant lifestyle factors, including dietary intake, physical activity, alcohol consumption, and smoking status. Lifestyle data, including dietary intake, were obtained using a self‐administered questionnaire. Adjusted geometric means of serum hs‐CRP levels were calculated based on OBS quartiles, and linear trend tests were performed, with adjustments for potential confounders. In addition, an inflammatory cytokine z‐score was constructed and assessed alongside individual markers.ResultsAfter adjusting for multiple confounders in both sexes, the results showed a significant inverse association between OBS and serum hs‐CRP levels in both men and women. These results remained unaltered when the OBS evaluation excluded powerful prooxidants, serum ferritin, or smoking. There was also an association between OBS and lower inflammatory z‐score, indicating reduced overall systemic inflammation.ConclusionsThese findings suggest that a higher OBS, indicating a greater predominance of antioxidants over prooxidant exposure, is associated with lower hs‐CRP levels and reduced systemic inflammation, regardless of sex.
Consistency in Verreaux's sifaka home range and core area size despite seasonal variation in resource availability as assessed by Enhanced Vegetation Index (EVI)
Authors: Axel Anne C. , Harshbarger Brynn M. , Lewis Rebecca J. , Tecot Stacey R. 
Published: March 2024

AbstractPrimates are adept at dealing with fluctuating availability of resources and display a range of responses to minimize the effects of food scarcity. An important component of primate conservation is to understand how primates adapt their foraging and ranging patterns in response to fluctuating food resources. Animals optimize resource acquisition within the home range through the selection of resource‐bearing patches and choose between contrasting foraging strategies (resource‐maximizing vs. area‐minimizing). Our study aimed to characterize the foraging strategy of a folivorous primate, Verreaux's sifaka (Propithecus verreauxi), by evaluating whether group home range size varied between peak and lean leaf seasons within a seasonally dry tropical forest in Madagascar. We hypothesized that Verreaux's sifaka used the resource maximization strategy to select high‐value resource patches so that during periods of resource depression, the home range area did not significantly change in size. We characterized resource availability (i.e., primary productivity) by season at Kirindy Mitea National Park using remotely‐sensed Enhanced Vegetation Index data. We calculated group home ranges using 10 years of focal animal sampling data collected on eight groups using both 95% and 50% kernel density estimation. We used area accumulation curves to ensure each group had an adequate number of locations to reach seasonal home range asymptotes. Neither 95% home ranges nor 50% core areas differed across peak and lean leaf resource seasons, supporting the hypothesis that Verreaux's sifaka use a resource maximization strategy. With a better understanding of animal space use strategies, managers can model anticipated changes under environmental and/or anthropogenic resource depression scenarios. These findings demonstrate the value of long‐term data for characterizing and understanding foraging and ranging patterns. We also illustrate the benefits of using satellite data for characterizing food resources for folivorous primates.
Link among apolipoprotein E E4, gait, and cognition in neurodegenerative diseases: ONDRI study
Authors: Sakurai Ryota , Pieruccini‐Faria Frederico , Cornish Benjamin , Fraser Julia , Binns Malcolm A. , Beaton Derek , Dilliott Allison Ann , Kwan Donna , Ramirez Joel , Tan Brian , Scott Christopher J. M. , Sunderland Kelly M. , Tartaglia Carmela , Finger Elizabeth , Zinman Lorne , Freedman Morris , McLaughlin Paula M. , Swartz Richard H. , Symons Sean , Lang Anthony E. , Bartha Robert , Black Sandra E. , Masellis Mario , Hegele Robert A. , McIlroy William ,   ONDRI Investigators, Montero‐Odasso Manuel 
Published: March 2024

AbstractINTRODUCTIONApolipoprotein E E4 allele (APOE E4) and slow gait are independently associated with cognitive impairment and dementia. However, it is unknown whether their coexistence is associated with poorer cognitive performance and its underlying mechanism in neurodegenerative diseases.METHODSGait speed, APOE E4, cognition, and neuroimaging were assessed in 480 older adults with neurodegeneration. Participants were grouped by APOE E4 presence and slow gait. Mediation analyses were conducted to determine if brain structures could explain the link between these factors and cognitive performance.RESULTSAPOE E4 carriers with slow gait had the lowest global cognitive performance and smaller gray matter volumes compared to non‐APOE E4 carriers with normal gait. Coexistence of APOE E4 and slow gait best predicted global and domain‐specific poorer cognitive performances, mediated by smaller gray matter volume.DISCUSSIONGait slowness in APOE E4 carriers with neurodegenerative diseases may indicate extensive gray matter changes associated with poor cognition.Highlights
APOE E4 and slow gait are risk factors for cognitive decline in neurodegenerative diseases.
Slow gait and smaller gray matter volumes are associated, independently of APOE E4.
Worse cognition in APOE E4 carriers with slow gait is explained by smaller GM volume.
Gait slowness in APOE E4 carriers indicates poorer cognition‐related brain changes.
BIN1K358R suppresses glial response to plaques in mouse model of Alzheimer's disease
Authors: Garcia‐Agudo Laura Fernandez , Shi Zechuan , Smith Ian F. , Kramár Enikö A. , Tran Katelynn , Kawauchi Shimako , Wang Shuling , Collins Sherilyn , Walker Amber , Shi Kai‐Xuan , Neumann Jonathan , Liang Heidi Yahan , Da Cunha Celia , Milinkeviciute Giedre , Morabito Samuel , Miyoshi Emily , Rezaie Narges , Gomez‐Arboledas Angela , Arvilla Adrian Mendoza , Ghaemi Daryan Iman , Tenner Andrea J. , LaFerla Frank M. , Wood Marcelo A. , Mortazavi Ali , Swarup Vivek , MacGregor Grant R. , Green Kim N. 
Published: March 2024

AbstractINTRODUCTIONThe BIN1 coding variant rs138047593 (K358R) is linked to Late‐Onset Alzheimer's Disease (LOAD) via targeted exome sequencing.METHODSTo elucidate the functional consequences of this rare coding variant on brain amyloidosis and neuroinflammation, we generated BIN1K358R knock‐in mice using CRISPR/Cas9 technology. These mice were subsequently bred with 5xFAD transgenic mice, which serve as a model for Alzheimer's pathology.RESULTSThe presence of the BIN1K358R variant leads to increased cerebral amyloid deposition, with a dampened response of astrocytes and oligodendrocytes, but not microglia, at both the cellular and transcriptional levels. This correlates with decreased neurofilament light chain in both plasma and brain tissue. Synaptic densities are significantly increased in both wild‐type and 5xFAD backgrounds homozygous for the BIN1K358R variant.DISCUSSIONThe BIN1 K358R variant modulates amyloid pathology in 5xFAD mice, attenuates the astrocytic and oligodendrocytic responses to amyloid plaques, decreases damage markers, and elevates synaptic densities.Highlights
BIN1 rs138047593 (K358R) coding variant is associated with increased risk of LOAD.
BIN1 K358R variant increases amyloid plaque load in 12‐month‐old 5xFAD mice.
BIN1 K358R variant dampens astrocytic and oligodendrocytic response to plaques.
BIN1 K358R variant decreases neuronal damage in 5xFAD mice.
BIN1 K358R upregulates synaptic densities and modulates synaptic transmission.
Postintensive care syndrome family: A comprehensive review
Authors: Shirasaki Kasumi , Hifumi Toru , Nakanishi Nobuto , Nosaka Nobuyuki , Miyamoto Kyohei , Komachi Miyuki H. , Haruna Junpei , Inoue Shigeaki , Otani Norio 
Published: March 2024

AbstractFamilies of critically ill patients are predisposed to tremendous burdens when their relatives are admitted to the intensive care unit (ICU). Postintensive care syndrome family (PICS‐F) can be described as a devastated life, encompassing psychological, physical, and socioeconomical burdens that begin with the emotional impact experienced by the family when the patient is admitted to the ICU. PICS‐F was primarily proposed as a clinically significant psychological impairment, but it needs to be extended beyond the psychological impairment of the family to include physical and socioeconomical impairments in the future. The prevalence of physiological problems including depression, anxiety and post‐traumatic syndrome is 20–40%, and that of non‐physiological problems including fatigue is 15% at 6 months after the ICU stay. Assessment of PICS‐F was frequently conducted at 3‐ or 6‐month points, although the beginning of the evaluation was based on different assessment points among each of the studies. Families of ICU patients need to be given and understand accurate information, such as the patient's diagnosis, planned care, and prognosis. Prevention of PICS‐F requires a continuous bundle of multifaceted and/or multidisciplinary interventions including providing a family information leaflet, ICU diary, communication facilitators, supportive grief care, and follow‐up, for the patient and families from during the ICU stay to after discharge from the ICU. This is the first comprehensive review of PICS‐F to address the concept, risk factors, assessment tools, prevalence, and management to prevent PICS‐F to facilitate acute care physicians' understanding of PICS‐F.
Aluminagerma[5]pyramidane – Bildung und Gerüstumlagerung
Authors: Bührmann Lukas , Albers Lena , Beuße Maximilian , Schmidtmann Marc , Müller Thomas 
Published: March 2024

AbstractSalzmetathesereaktionen zwischen Dikaliumgermacyclopentadiendiiden und Aluminium(III)dichloriden ermöglichen die Synthese von Alumol‐Halbsandwichkomplexen des zweiwertigen Germaniums oder von Aluminylen‐Germol‐Komplexen. Deren Molekülstrukturen und ihre delokalisierte Bindungssituation, wie sie durch Dichtefunktionalrechnungen (DFT) belegt wird, erlauben gleichermaßen ihre Beschreibung als isomere Aluminagerma[5]pyramidane mit entweder dem Germanium‐ oder dem Aluminiumatom in der apikalen Position der pentagonalen Pyramide. Die Produktbildung und die Selektivität der Reaktion hängen von dem dritten Substituenten des Aluminiumdichlorids ab. Arylgruppen begünstigen die Bildung von Alumolkomplexen und der Cp*‐Substituent die der isomeren Germolkomplexe. Mit Aminosubstituenten am Aluminiumatom werden Mischungen beider Isomere erhalten, wobei der Austausch der Positionen der beiden Heteroatome im Pyramidan durch NMR Spektroskopie nachgewiesen wurde. Zudem können, ausgehend von Alumolkomplexen des zweiwertigen Germaniums, durch reduktive Eliminierung des Germaniums die entsprechenden Alumole erhalten werden.