bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of clinical nursing pathway on the surgical site wound infection in patients undergoing knee or hip replacement surgery: A meta‐analysis
Authors: Huang Zhifeng , Li Yuanli , Peng Jing , Wang Hao , Shen Kai , Li Ya , Yu Keping 
Published: March 2024

AbstractTo explore the effect of clinical nursing pathway on wound infection in patients undergoing knee or hip replacement surgery. Computerised searches of PubMed, Web of Science, Cochrane Library, Embase, Wanfang, China Biomedical Literature Database, China National Knowledge Infrastructure databases were conducted, from database inception to September 2023, on the randomised controlled trials (RCTs) of application of clinical nursing pathway to patients undergoing knee and hip arthroplasty. Literature was screened and evaluated by two researchers based on inclusion and exclusion criteria, and data were extracted from the final included literature. RevMan 5.4 software was employed for data analysis. Overall, 48 RCTs involving 4139 surgical patients were included, including 2072 and 2067 in the clinical nursing pathway and routine nursing groups, respectively. The results revealed, compared with routine nursing, the use of clinical nursing pathways was effective in reducing the rate of complications (OR = 0.17, 95%CI: 0.14–0.21, p < 0.001) and wound infections (OR = 0.29, 95%CI: 0.16–0.51, p < 0.001), shortens the hospital length of stay (MD = −4.11, 95%CI: −5.40 to −2.83, p < 0.001) and improves wound pain (MD = −1.34, 95%CI: −1.98 to −0.70, p < 0.001); it also improve patient satisfaction (OR = 7.13, 95%CI: 4.69–10.85, p < 0.001). The implementation of clinical nursing pathways in clinical care after knee or hip arthroplasty can effectively reduce the incidence of complications and wound infections, and also improve the wound pain, while also improving treatment satisfaction so that patients can be discharged from the hospital as soon as possible.
Impact of stapler versus manual closure techniques on pharyngocutaneous fistula development post‐total laryngectomy: A systematic review and meta‐analysis
Authors: Ding Shuo , Zhang Yang , Guo Wei , Yin Gaofei , Huang Zhigang , Zhong Qi 
Published: March 2024

AbstractPharyngocutaneous fistula (PCF) is a major complication after total laryngectomy, with significant morbidity and mortality. Whether mechanical stapler closure of the pharynx reduces fistula rates compared to hand‐sewn techniques remains unclear. We conducted an updated systematic review and meta‐analysis to clarify this question. Five databases were systematically searched from inception through November 2023 for studies comparing stapler versus suture closure for fistula outcomes after laryngectomy. Odds ratios (OR) were pooled using random‐effects models and fixed‐effects models. Subgroup and sensitivity analyses were performed. Risk of bias was appraised using NHLBI tools. Nine studies with 803 patients were included. Mechanical closure significantly reduced fistula incidence versus suture closure (OR = 0.57, 95% CI 0.34–0.95, p = 0.03). Subgroup analysis found that stapling's protective effect varied by patient age, country/region, linear stapler size and female percentage. Stapling reduced fistula odds by 80% in the Turkey subgroup (OR = 0.20, 95% CI 0.09–0.50) but showed no benefit in other regions. Patients <60 years showed an 84% fistula reduction with stapling (OR = 0.17, 95% CI 0.06–0.45), whereas older subgroups did not. Linear stapler size of 60 mm significantly reduced fistula occurrence while 75 mm did not. There was no evidence that low female percentage mitigated stapling benefits. Mechanical stapler closure after total laryngectomy meaningfully reduces the likelihood of postoperative PCF formation compared to hand‐sewn closure, especially for patients younger than 60 years old. The absolute risk reduction supports its utility to prevent this complication.
RETRACTED: Effects of high tibial osteotomy compared with unicondylar knee arthroplasty on the surgical site wound infection and pain in patients with medial knee osteoarthritis
Authors: Li Jingcheng , Zhang Yang , Chen Yonghua , Li Ying , Dai Baifa , Liu Ping 
Published: March 2024

AbstractThis study aims to comprehensively compare the effects of unicondylar knee arthroplasty (UKA) and high tibial osteotomy (HTO) on wound infection and pain in patients with medial knee osteoarthritis. A computerized search was conducted in Embase, PubMed, Google Scholar, China National Knowledge Infrastructure, Cochrane Library and Wanfang databases, from database inception to October 2023, for studies comparing UKA and HTO for medial knee osteoarthritis. Studies selection, data extraction and study quality evaluation were independently conducted by two researchers. Stata 17.0 software was employed for data analysis. Overall, 10 studies involving 870 patients with medial knee osteoarthritis were included. It was found that the UKA group had significantly lower wound visual analogue scale scores compared to the HTO group (SMD = ‐0.53, 95%CI: −0.87 to −0.20, p < 0.001). The incidence of wound infection in the UKA group was higher than in the HTO group (OR = 1.92, 95%CI: 0.65–5.69, p = 0.240), and the incidence of complications was lower (OR = 0.89, 95%CI: 0.52–1.54, p = 0.684), though these differences were not statistically significant. This study indicates that UKA is effective in alleviating postoperative wound pain in medial knee osteoarthritis. However, the rates of postoperative wound infection and complications are comparable to those of HTO. Clinicians should consider factors such as patient age and disease severity in making individualized treatment decisions.
Impact of prophylactic wound closure in colorectal ESD on postoperative wound complications: A meta‐analysis
Authors: Fang Zhengdong , Xu Yan , Huang Xiaolin 
Published: March 2024

AbstractEndoscopic submucosa dissection (ESD) has been applied extensively in the treatment of large intestine tumours due to its high total excision ratio. Nevertheless, there is a high incidence of adverse reactions in colon ESD, and the efficacy of prophylactic ESD following ESD in prevention of postoperative haemorrhage is still disputed. The purpose of this meta‐analysis is to evaluate the effectiveness of prophylaxis of wound closure in large intestine ESD after operation. For eligibility, we looked through three databases: PubMed, Embase and Cochrane Library. Heterogenity was measured by means of a chi‐square method of Q‐statistic and an I2 test. Fixed or random effects models were used for data processing. Based on the retrieval policy, we found a total of 1286 papers, and then we collected nine papers to extract the data. Regarding postoperative haemorrhage, there was a significant reduction in the risk of wound haemorrhage in the wound closure group than in the control group (OR, 0.29; 95% CI, 0.19–0.44 p < 0.0001). No statistical significance was found in the incidence of perforation in the wound closure and the control group (OR, 0.45; 95% CI, 0.19–1.03 p = 0.06). There was a significant reduction in the incidence of postoperation fever among those in the wound closure group than in the control group (OR, 0.37; 95% CI, 0.15–0.93 p = 0.04). Preventive endoscopic closure decreased the rate of ESD in colon disease, but did not significantly decrease the rate of postoperation perforation and postoperative fever. Future research will be required to clarify the risk factors and classify high‐risk individuals in order to formulate a cost‐effective prevention strategy.
Effect of two different surgical modalities for pelvic organ prolapse on postoperative wound infection in patients: A meta‐analysis
Authors: Cui Hongyin , Lang Xiaolin , Huang Changchang , Sun Jie 
Published: March 2024

AbstractSacrospinous ligament fixation (SSLF) is widely applied to the treatment of female pelvis organ prolapsed. Contradictory findings have already been reported in the comparison of sacrocolpopexy (SC) with SSLF. The objective of this study is to evaluate the efficacy of SC versus SSLF in treating pelvis organ prolapsed after operation. We conducted a meta‐analysis of both operative approaches, including PubMed, Embase, and Cochrane Library. In this research, 822 articles were chosen from three databases, 201 were copied, and 10 were included. Among them, 7248 cases were operated on the prolapsed pelvis. It was found that SSLF surgery could significantly decrease the rate of postoperative wound infection after operation (odds ratio [OR], 0.59; 95% confidence interval [CI], 0.42–0.82; p = 0.001). No statistical significance was found among the SSLF and the SC surgery for the post‐operation haemorrhage of the patient (OR, 0.81; 95% CI, 0.23–2.83; p = 0.75). No statistical significance was found among the SSLF and the SC surgery for the postoperative period of the patient's operation (mean difference, −15.46; 95% CI, −52.87 to 21.94; p = 0.42). Applying SSLF surgery to treat pelvic prolapse in women may benefit from a reduction in the number of post‐operative wound infections. However, SSLF had no statistical significance with respect to the amount of haemorrhage after operation or operation time.
A standardized wound infection model for antimicrobial testing of wound dressings in vitro
Authors: Wiegand Cornelia , Fink Sarah , Mogrovejo Diana C. , Ruhlandt Marina , Wiencke Vanessa , Eberlein Thomas , Brill Florian H. H. , Tittelbach Jörg 
Published: March 2024

AbstractTo investigate the effectiveness of antimicrobial agents against wound infections, experiments using either 2D cultures with planktonic microorganisms or animal infection models are frequently carried out. However, the transferability of the results to human skin is limited by the lack of complexity of the 2D models or by the poor translation of the results from animal models. Hence, there is a need for wound infection models capable of assessing antimicrobial agents. In this study, an easily standardized wound infection model was established. This model consists of a mechanically wounded human skin model on a collagen matrix infected with various clinically relevant bacteria. Infection of the model led to recognition of the pathogens and induction of an inflammatory response. The untreated infection spread over time, causing significant tissue damage. By applying an antimicrobial‐releasing wound dressing, the bacterial load could be reduced and the success of the treatment could be further measured by a decrease in the inflammatory reaction. In conclusion, this wound infection model can be used to evaluate new antimicrobial therapeutics as well as to study host‐pathogen interactions.
New application of traditional S retractor in collecting wound flushing fluid after skin tumour resection
Authors: Liu Yuancheng , Zhao Shuang , Liu Xin , Hu Xiheng 
Published: March 2024

AbstractAfter Skin tumour resection, there may be residual tumour cells on the wound surface, washing the wound surface with sterilized water can mediate tumour cell lysis and improve patient prognosis. We observed that when the patient is lying behind the operating table, both the limbs and trunk will form an inclined plane with a high centre and a low periphery. Fit the hook of the traditional S retractor onto the low end of the inclined surface, and apply appropriate pressure to make the fitting tight. This way, the flushing fluid will converge at the low end of the fitting surface and will not leak out. Combined with a negative pressure aspirator, it can reduce the splashing of flushing fluid. The traditional S retractor is common in the operating room, which is easy to operate and do not increase medical costs. The method of using a traditional S retractor to collect flushing fluid is worth further promotion.
How Have EU Legislators Established EU Agencies With Enforcement Tasks? Case Studies of the European Aviation Safety Agency and the European Medicines Agency
Authors: van Kreij Laurens 
Published: March 2024

AbstractEuropean Union (EU) policies were long enforced according to a well‐established framework in which member state governments made legislative, administrative and operational arrangements for realizing policies made in Brussels. EU legislators, however, are increasingly creating EU agencies to help enforce EU policies. This article attempts to explain this puzzling development, as it examines how the establishment of EU enforcement agencies by EU legislators relates to the well‐established role of member states. This article relies on case studies of the European Aviation Safety Agency (EASA) and the European Medicines Agency (EMA). These case studies show that, during the establishment of those agencies, the member state enforcement framework provided institutional stability on the one hand yet facilitated institutional change on the other. This institutionalist account of EU agency establishment supplements functional and political ones that have so far prevailed in the academic discourse.
Effect of the type of application tip for 35% hydrogen peroxide on bleaching efficacy and tooth sensitivity: A randomized clinical trial
Authors: Centenaro Gabrielle G. , Favoreto Michael W. , Cordeiro Deisy C. F. , Gumy Fernanda N. , Machado Amanda G. , Cochinski Gabriel D. , Reis Alessandra , Loguercio Alessandro D. 
Published: March 2024

AbstractObjectivesEvaluate the bleaching efficacy (BE) and tooth sensitivity (TS) of in‐office bleaching using different application tips.MethodsForty‐eight participants were selected (split‐mouth), one to receive bleaching with an attached brush tip and one with a conventional tip. The procedure was performed with Whiteness Automixx Plus 35%. The BE was evaluated at the beginning, weekly, one and 12 months post‐bleaching with a Vita Easyshade spectrophotometer (ΔE*ab, ΔE00, and WID) and with Vita classical A1‐D4 and Vita Bleachedguide shade guides units (ΔSGU). Absolute risk and intensity of TS were recorded using the Visual Analogue Scale. The equivalence of BE was analyzed using the two one‐sided t‐tests for paired samples. The absolute risk of TS was evaluated using the McNemar test, and the TS intensity was measured with the paired t test (α = 0.05).ResultsThe equivalence of BE was observed for both groups in all color evaluations (p > 0.05). A lower absolute risk and intensity of TS were observed for the attached brush tip when compared with the conventional tip (p < 0.003 and p < 0.0001).ConclusionUsing an attached brush tip showed the same BE as a conventional tip. However, for the attached brush tip, there was a reduction in TS.Clinical SignificanceThe applicator‐attached brush tip is recommended for in‐office dental bleaching, because of the possible reduction in risk and intensity of TS.
Early ontogenesis from embryo to juvenile in Senegalese sole Solea senegalensis under laboratory conditions
Authors: Liu Liming , Zeng Jun , Wang Jiulong , Liu Yan , Mei Weiping , Wu Yanqin , Wang Chengwu , Xu Wengang 
Published: March 2024

AbstractSenegalese sole, Solea senegalensis, is a flatfish of high commercial value in the world. It has been identified as an interesting and promising species for marine commercial aquaculture diversification in Europe for at least four decades and was introduced to China in 2003. Early ontogenesis from embryo to juvenile stages in S. senegalensis was analysed under controlled laboratory conditions to provide morphological information for aquaculture. From 0 to 59 days post hatching (dph), 10–20 larvae were sampled and measured each day (0–17 dph) or every 2–6 days (17–59 dph). Morphological characteristics from the egg to the juvenile stage were described. The eggs were separate and spherical with multiple oil globules. After 3 dph, the yolk sac was completely absorbed, mouth and anus were open, a swim bladder appeared, and larvae began feeding on rotifers (Brachionus plicatilis). The larvae began metamorphosis as the notochord flexed upward and the left eye migrated upward after 10 dph. The left eye migrated to the dorsal midline at 15 dph. At 19 dph, the left eye was translocated to the right‐ocular side, and the juveniles adopted a benthic lifestyle. The swim bladder degenerated, and the juveniles completed metamorphosis at 23 dph. The growth patterns of some parameters (TL, SL, BH, BW) during larval and juvenile development stages were identified. The inflection points, which are slopes of growth changes, were calculated in growth curves. Three inflection points occurring in the growth curves of larvae and juveniles were found to be associated with metamorphosis, weaning, and transitions in feeding habits. The basic information of embryo development and ontogenesis in this study represents a valuable contribution to the S. senegalensis industry, especially in artificial breeding and rearing techniques.
The influence of swirl intensity on the prediction model of wheat picking speed
Authors: Shang Kun , Li Yongxiang , Song Haihao , Xu Xuemeng , Zhang Hanshan 
Published: March 2024

AbstractTo study the effect of swirl intensity on the picking speed of wheat particles, a test bench for the transportation status of bulk grain particles was developed, and a theoretical model for the picking speed of wheat particles transported by swirl was established. Firstly, the critical conveying speed is determined through theoretical analysis and budgeted using the C&K model. Then, experiments are conducted to pick up loose grain particles in different flow fields. The particles in the swirling field are gradually rolled up from the windward end and sequentially pushed backwards to be picked up and transported. The picking speed of loose grain particles shows a trend of first increasing and then decreasing with the increase of swirling intensity. Using dimensionless swirl intensity as a variable, a predictive model for the effect of swirl intensity on particle picking speed during swirl conveying of wheat particles is derived.Practical applicationsWhen conveying bulk grain particles through a swirling flow, the intensity of swirling flow is closely related to the picking speed of bulk grain particles. This is extremely important for setting the wind speed of the conveying system, as it directly affects the energy consumption, particle crushing, and conveying efficiency of the entire system. Therefore, it is extremely important to predict the picking speed of bulk grain particles under different swirling strengths to control the corresponding wind speed. Therefore, this study conducts in‐depth research on this issue.
Telemedicine for Routine Prenatal Care: Use and Satisfaction During the COVID‐19 Pandemic
Authors: Wu Katrina K. , Phillippi Julia , Mueller Martina , Lopez Cristina , Nichols Michelle 
Published: March 2024

IntroductionTelemedicine use in prenatal care has greatly expanded without substantial research. Optimizing user experiences can increase telemedicine's utilization to support care access. The purpose of this study was to explore patient and provider experiences using telemedicine for routine prenatal care during the COVID‐19 pandemic, identifying factors affecting its utilization and satisfaction.MethodsIn this mixed methods study, online surveys and semi‐structured interviews with pregnant and postpartum patients and perinatal providers across the United States were used to explore experiences with telemedicine and prenatal care during the COVID‐19 pandemic. Data were collected from July to December 2021. Survey findings were analyzed using descriptive and inferential statistics, and interviews were thematically coded and analyzed, followed by mixed methods analysis.ResultsResults of 946 surveys (750 patients and 196 providers) and 30 interviews (15 patients and 15 providers) met inclusion for analysis. Telemedicine was utilized by 42% of patients and 72% of perinatal provider participants. The primary reason patients did not use telemedicine was because it was not offered. Patients and providers who did not use telemedicine expressed the following main concerns with virtual care: uncertainty about care quality, particularly when blood pressure and the fetal heart rate were not assessed, and potential challenges with developing trusting patient‐provider relationships. Patients and providers who used telemedicine rated their experience as mild to moderate satisfaction across the 6 Telehealth Usability Questionnaire domains. Satisfaction scores were not dependent on whether physical examination components were included in virtual visits.DiscussionProviding patients with the choice to use telemedicine as needed or combined with in‐person visits for routine prenatal care may increase care utilization. Although not directly linked with satisfaction, interest in using telemedicine would likely increase for patients and providers concerned with care quality if blood pressure and fetal heart rate are assessed during virtual visits.
Evaluation of the parameters in predicting single‐dose methotrexate therapy success for ectopic pregnancy
Authors: Deniz Simsek , Ali Bahadırlı , Canan Urun , Yılmaz Akın Hasan , Olcay Ilhan , Burcu Dincgez , Fatma Gencer Ketenci 
Published: March 2024

AbstractAimMethotrexate has demonstrated efficacy in treating ectopic pregnancies. This study explores factors influencing treatment success, focusing on laboratory and ultrasonographic findings, particularly the day 4 to day 1 β‐hCG level ratio.MethodsRetrospective cohort study was conducted within patients diagnosed with tubal ectopic pregnancy. Patients' characteristics, ultrasound findings, laboratory data, and β‐hCG levels (days 1, 4, 7), and operation findings were reviewed. Women's characteristics were investigated who were treated with single dose of MTX (50 mg/m2). Patients who were performed surgery after MTX treatment were identified as MTX treatment failure.ResultsAmong 439 women, 259 underwent surgery due to acute symptoms. Of those treated with MTX, 143 experienced treatment success, while 37 underwent surgery after MTX (MTX failure). Comparative analysis revealed significant differences in β‐hCG levels on admission (1128 and 4125 mIU/mL) and the day 4 to day 1 β‐hCG ratio (0.91 and 1.25). The overall MTX success rate was 79%, reaching 93% and 89% for β‐hCG levels <1000 mIU/mL and <2000 mIU/mL, respectively. Success dropped to 50% with levels exceeding 5000 mIU/mL. ROC analysis identified a crucial 2255 mIU/mL cut‐off for β‐hCG (sensitivity 70.3% and specificity 68.5%) and a day 4 to day 1 β‐hCG ratio of 95.5% (sensitivity 84.7%, specificity 72.5%, positive predictive value 75.4%) for predicting MTX success.ConclusionEstablishing a β‐hCG cutoff can reduce hospital stay. The day 4 to day 1 β‐hCG ratio holds promise as a widely applicable predictor for MTX success or for determining MTX administration on day 4.