bluuebunny/crossref_metadata_2025_split huggingface dataset:
D,L‐α‐Tocopherol Synthesis Catalyzed by the Broensted Acidic Ionic Liquids.
Authors: Xing Huabing , Wang Tao , Zhou Zhenhuan , Dai Youyuan 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis and Biological Evaluation of 3‐Amino‐4‐aryl‐piperidine Derivatives as BACE 1 Inhibitors.
Authors: Lim Hee‐Jong , Jung Myung Hee , Lee Ihl Young Choi , Park Woo Kyu 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
α‐Cyclization of Tertiary Amines: Synthesis of Some Novel Anellated Quinolines via a Three‐Component Reaction under Solvent‐Free Conditions.
Authors: Devi Ipsita , Baruah Biswajita , Bhuyan Pulak J. 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Antimony Chloride Doped on Hydroxyapatite Catalyzed Stereoselective One‐Pot Synthesis of Pyrano[3,2‐c]quinolines.
Authors: Mahajan Deepali , Ganai Bilal A. , Sharma Rattan Lal , Kapoor Kamal K. 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Convenient Route for the Synthesis of Pyrazolo[3,4‐d]pyrimidine, Pyrazolo[3,4‐b][1,6]naphthyridine and Pyrazolo[3,4‐b]quinoline Derivatives.
Authors: Jachak Madhukar N. , Avhale Appasaheb B. , Medhane Vijay J. , Toche Raghunath B. 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis and Anticonvulsant Activity of Some Potential Thiazolidinonyl 2‐Oxo/Thiobarbituric Acids.
Authors: Agarwal A. , Lata S. , Saxena K. K. , Srivastava V. K. , Kumar A. 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Hydrothermal Syntheses of Some Derivatives of Tetraazatriphenylene.
Authors: Che Guangbo , Li Wenlian , Kong Zhiguo , Su Zisheng , Chu Bei , Li Bin , Zhang Zhiqiang , Hu Zhizhi , Chi Haijun 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of Substituted 4‐(3‐Alkyl‐1,2,4‐oxadiazol‐5‐ylmethyl)‐3,4‐dihydro‐2H‐1,4‐benzoxazines and 4‐(1H‐Benzimidazol‐2‐ylmethyl)‐3,4‐dihydro‐2H‐1,4‐benzoxazines.
Authors: Mizar Pushpak , Myrboh Bekington 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Singlet Oxygen Addition to Chiral Allylic Alcohols and Subsequent Peroxyacetalization with β‐Naphthaldehyde: Synthesis of Diastereomerically Pure 3‐β‐Naphthyl‐Substituted 1,2,4‐Trioxanes.
Authors: Griesbeck Axel G. , El‐Idreesy Tamer T. , Lex Johann 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A New Acridine Derivative as a Fluorescent Chemosensor for Zinc Ions in a 100% Aqueous Solution: A Comparison of Binding Property with Anthracene Derivative.
Authors: Park Min Sun , Swamy K. M. K. , Lee Yoon Ju , Lee Han Na , Jang Yun Jung , Moon Young Hyun , Yoon Juyoung 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Diversity‐Oriented Approach to Biologically Relevant Molecular Frameworks Starting with β‐Naphthol and Using the Claisen Rearrangement and Olefin Metathesis as Key Steps.
Authors: Kotha Sambasivarao , Mandal Kalyaneswar , Tiwari Arti , Mobin Shaikh M. 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Work‐Up‐Free Deprotection of Borane Complexes of Phosphines, Phosphites, and Phosphinites with Polymer‐Supported Amines.
Authors: Sayalero Sonia , Pericas Miquel A. 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Preparation of 2‐Amino‐1,3‐selenazoles by Reaction of N,N‐Unsubstituted Selenoureas with α,β‐Unsaturated Ketones in Alcohol.
Authors: Koketsu Mamoru , Kanoh Koichi , Ishihara Hideharu 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Polymer‐Assisted Solution‐Phase Strategy for the Synthesis of Fused [2,1‐b]Quinazolinones and the Preparation of Optically Active Vasicinone (VIII).
Authors: Kamal Ahmed , Devaiah V. , Shankaraiah N. , Reddy K. Laxma 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Diverse Suite of Spiroacetals, Including a Novel Branched Representative, is Released by Female Bactrocera tryoni (Queensland Fruit Fly)
Authors: Booth Yvonne K. , Schwartz Brett D. , Fletcher Mary T. , Lambert Lynette K. , Kitching William , De Voss James J. 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Novel Antiproliferative Agent, Phenylpyridineylbutenol, Isolated from Streptomyces sp.
Authors: Shin Choonshik , Lim Haeyoung , Moon Sangik , Kim Seunghyun , Yong Yeonjoong , Kim Bum‐Joon , Lee Chul‐Hoon , Lim Yoongho 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
The Impact of Tautomer Forms on Pharmacophore‐Based Virtual Screening.
Authors: Oellien Frank , Cramer Joerg , Beyer Carsten , Ihlenfeldt Wolf‐Dietrich , Selzer Paul M. 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Learning from the Data: Mining of Large High‐Throughput Screening Databases.
Authors: Yan S. Frank , King Frederick J. , He Yun , Caldwell Jeremy S. , Zhou Yingyao 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Substructure‐Based Support Vector Machine Classifiers for Prediction of Adverse Effects in Diverse Classes of Drugs.
Authors: Bhavani S. , Nagargadde A. , Thawani A. , Sridhar V. , Chandra N. 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Fabrication of Rod‐Like CeO2: Characterization, Optical and Electrochemical Properties.
Authors: Zhang Dong‐En , Ni Xiao‐Min , Zheng Hua‐Gui , Zhang Xiao‐Jun , Song Ji‐Mei 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Intramolecular Reductive Cyclizations Using Electrochemistry: Development of Environmentally Friendly Synthetic Methodologies
Authors: Dunach Elisabet , Medeiros Maria Jose , Olivero Sandra 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Chemieschulbücher in der Unterrichtsplanung ‐ Welche Bedeutung haben Schülervorstellungen?
Authors: Beerenwinkel Anne , Parchmann Ilka , Gräsel Cornelia 
Published: January 2007

AbstractDas konstruktivistische Modell des Wissenserwerbs stellt Lernen als einen aktiven, zielgerichteten Prozess dar. Das Vorwissen des Einzelnen beeinflusst grundlegend, welche Informationen wahrgenommen und wie sie interpretiert werden. Auch im naturwissenschaftlichen Bereich bringen Schüler viele Vorstellungen mit in den Unterricht, die nicht mit den wissenschaftlichen übereinstimmen. Ein Nichtaufgreifen dieser Ideen kann zu Lernschwierigkeiten führen [z.B. 1, 2]. In diesem Zusammenhang stellt sich die Frage, wie Ergebnisse der Forschung zu Schülervorstellungen in die Praxis umgesetzt werden können. Einen Ansatzpunkt bieten hier Medien, die Lehrkräfte für ihre Unterrichtsplanung verwenden. Eines der wichtigsten Medien für die Vorbereitung im Fach Chemie ist nach einer Untersuchung von Daus et al. [3] das Schulbuch. Dies deckt sich mit den Ergebnissen einer eigenen Befragung von Chemielehrkräften, die wir 2004 durchführten. In einer qualitativen Analyse wurde daraufhin exemplarisch anhand der Thematik „Teilchenmodell”︁ untersucht, inwieweit bekannte Fehlkonzepte in Chemieschulbüchern aufgegriffen werden. Die Ergebnisse der Lehrerbefragung und der Schulbuchanalyse werden im folgenden Beitrag vorgestellt und diskutiert. Abschließend werden Beispiele aus einem Kriterienraster für eine bessere Integration von Schülervorstellungen in Lehrtexte vorgestellt.
Direct Coupling of Bromine‐Mediated Methane Activation and Carbon‐Deposit Gasification
Authors: Osterwalder Neil , Stark Wendelin J. 
Published: January 2007

AbstractThe direct bromination of methane offers a quite selective (>98 %) route towards methane activation but shifts the problem of fuel production to converting and handling corrosive methyl bromide. The direct conversion of methyl bromide, at about 200 °C, into light hydrocarbons can be catalyzed under pressure by AlBr3 resulting in the formation of propane‐rich mixtures of light hydrocarbons, carbonaceous deposits, and HBr. After releasing the gaseous products, the addition of hydrogen at 260 °C allows a quantitative conversion of the carbonaceous deposits into the same range of light hydrocarbons. These second‐stage products efficiently contribute to the overall process yield while enabling a full regeneration of the catalyst′s activity. This oxygen‐free process is compared to the conversion of methyl bromide on zeolites and the currently used methanol‐to‐gasoline (MTG) process in terms of product distributions and apparent energy of activation. A detailed chemical analysis of the intermediates revealed the presence of a carbon pool consisting of highly substituted benzene and cyclopentadiene derivatives, as observed on zeolites used in the MTG process. This similarity suggests that the currently used oxygen‐based syngas/MTG process for methane conversion may be extended to a bromine‐mediated process by using methyl bromide as an intermediate instead of methanol.
Cathepsin D gene expression outlines the areas of physiological cell death during embryonic development
Authors: Zuzarte‐Luis V. , Montero J.A. , Torre‐Perez N. , Garcia‐Porrero J.A. , Hurle J.M. 
Published: January 2007

AbstractThe implication of lysosomes in the activation of physiological cell death (PCD) was proposed some decades ago. In this work, we show that the expression of the lysosomal enzyme cathepsin D is up‐regulated in developing tissues undergoing apoptosis. By comparing vital and terminal deoxynucleotidyl transferase–mediated deoxyuridinetriphosphate nick end‐labeling (TUNEL) labeling patterns with in situ hybridization for this gene in a variety of tissues and organs, we show that this procedure constitutes a reliable technique to map the regions of PCD in the embryo. Using this methodological approach, we report the occurrence of two new areas of PCD in the developing limb. Developmental Dynamics 236:880–885, 2007. © 2007 Wiley‐Liss, Inc.
The role of chrysin and the Ah receptor in induction of the human UGT1A1 gene in vitro and in transgenic UGT1 mice
Authors: Bonzo Jessica A. , Bélanger Alain , Tukey Robert H. 
Published: January 2007

The flavonoid chrysin is an important dietary substance and induces UGT1A1 protein expression in cell culture. As a representative of the class of dietary flavonoids, clinical investigations have been considered as a means of inducing hepatic UGT1A1 expression. We demonstrate the necessity of a xenobiotic response element (XRE) in support of chrysin induction of UGT1A1 in the human hepatoma cell line HepG2. Receptor binding assays confirm that chrysin is a ligand for the Ah receptor by competition with [3H]2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). However, key differences in Ah receptor recognition and activation ofUGT1A1by chrysin exist when compared with classical mechanisms ofUGT1A1induction by TCDD. Ah receptor degradation, an indicator of Ah receptor activation, does not occur after chrysin treatment, and chrysin cannot transactivate the Ah receptor in a TCDD-dependent fashion. Knock-down of the Ah receptor by siRNA indicates that chrysin uses the Ah receptor in conjunction with other factors through MAP kinase signaling pathways to maximally induceUGT1A1. Most importantly, oral treatment of chrysin to transgenic mice that express the humanUGT1locus is unable to induce UGT1A1 expression in either the small intestine or liver.Conclusion:Although the implications for chrysin as an atypical agonist of the Ah receptor are intriguing at the molecular level, the relevance of chrysin-induced transcription for the purpose of clinical therapies or to regulate phase 2–dependent glucuronidation is questionable given the lack ofin vivoregulation of humanUGT1A1by chrysin in a transgenic animal model.
Activation of vascular adhesion protein-1 on liver endothelium results in an NF-κB–dependent increase in lymphocyte adhesion
Authors: Lalor Patricia F. , Sun Phoebe Jun , Weston Chris J. , Martin-Santos Azucena , Wakelam Michael J. O. , Adams David H. 
Published: January 2007

Vascular adhesion protein-1 (VAP-1) is an adhesion molecule and amine oxidase that is expressed at high levels in the human liver. It promotes leukocyte adhesion to the liverin vivoand drives lymphocyte transmigration across hepatic sinusoidal endothelial cellsin vitro. We report that in addition to supporting leukocyte adhesion, provision of specific substrate to VAP-1 results in hepatic endothelial cell activation, which can be abrogated by treatment with the enzyme inhibitor semicarbazide. VAP-1–mediated activation was rapid; dependent upon nuclear factor-κB, phosphatidylinositol-3 kinase, and mitogen-activated protein kinase pathways; and led to upregulation of the adhesion molecules E-selectin, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1 and secretion of the chemokine CXCL8. This response resulted in enhanced lymphocyte adhesion, was restricted to hepatic endothelial cells that expressed VAP-1, and was not observed in human umbilical vein endothelial cells.Conclusion :We propose that as well as directly promoting adhesion via interactions with the as yet unknown ligand, binding of enzyme substrate to VAP-1 can indirectly promote inflammatory cell recruitment via upregulation of adhesion molecules and chemokines. This response is likely to be important for the recruitment of leukocytes to the liver and suggests that VAP-1 inhibitors have therapeutic potential for treating chronic inflammatory liver disease.
Nonalcoholic fatty liver sensitizes rats to carbon tetrachloride hepatotoxicity
Authors: Donthamsetty Shashikiran , Bhave Vishakha S. , Mitra Mayurranjan S. , Latendresse John R. , Mehendale Harihara M. 
Published: January 2007

This study tested whether hepatic steatosis sensitizes liver to toxicant-induced injury and investigated the potential mechanisms of hepatotoxic sensitivity. Male Sprague-Dawley rats were fed a methionine- and choline-deficient diet for 31 days to induce steatosis. On the 32nd day, administration of a nonlethal dose of CCl4 (2 mL/kg, intraperitoneally) yielded 70% mortality in steatotic rats 12-72 hours after CCl4administration, whereas all nonsteatotic rats survived. Neither CYP2E1 levels nor covalent binding of [14C]CCl4-derived radiolabel differed between the groups, suggesting that increased bioactivation is not the mechanism for this amplified toxicity. Cell division and tissue repair, assessed by [3H]thymidine incorporation and proliferative cell nuclear antigen assay, were inhibited in the steatotic livers after CCl4administration and led to progressive expansion of liver injury culminating in mortality. The hypothesis that fatty hepatocytes undergo cell cycle arrest due to (1) an inability to replenish ATP due to overexpressed uncoupling protein-2 (UCP-2) or (2) induction of growth inhibitor p21 leading to G1/S phase arrest was tested. Steatotic livers showed 10-fold lower ATP levels due to upregulated UCP-2 throughout the time course after CCl4 administration, leading to sustained inhibition of cell division. Western blot analysis revealed an up-regulation of p21 due to overexpression of TGF β1 and p53 and down-regulation of transcription factor Foxm1b in steatotic livers leading to lower phosphorylated retinoblastoma protein. Thus, fatty hepatocytes fail to undergo compensatory cell division, rendering the liver susceptible to progression of liver injury.Conclusion :Impaired tissue repair sensitizes the steatotic livers to hepatotoxicity.
Two New Sesquiterpenes from Ligularia lankongensis
Authors: Tan Ai‐Min , He Hong‐Ping , Zhang Mian , Wang Zheng‐Tao , Hao Xiao‐Jiang 
Published: January 2007

AbstractIn continuation of a systematic investigation into the chemotaxonomic and bioactive components of pyrrolizidine alkaloids and sesquiterpenoids of Ligularia plants, two new, highly oxygenated, rare bisabolene sesquiterpenes, compounds 1 and 2, were isolated from the roots of Ligularia lankongensis. Their structures and relative configurations were elucidated by means of 1D‐ and 2D‐NMR as well as MS analyses.
Zirconyl Chloride (= Dichlorooxozirconium) as an Efficient Catalyst for One‐Pot Multicomponent Synthesis of Homoallylic Amines
Authors: Das Biswanath , Ravikanth Bommena , Reddy Kongara Ravinder , Rao Bommena Vittal 
Published: January 2007

AbstractZirconyl chloride (ZrOCl2) catalyzes efficiently the one‐pot three component reactions of aldehydes, amines, and allyltributylstannane at room temperature to furnish the corresponding homoallylic amines in short reaction times and in excellent yields.
Efficient Regio‐ and Stereoselective Conversions of Oxiranes and Aziridines into β‐(Nitrooxy)‐Substituted Alcohols and Amines by Using Bismuth Nitrate
Authors: Das Biswanath , Krishnaiah Maddeboina , Venkateswarlu Katta , Reddy Vtukuri Saidi 
Published: January 2007

AbstractOxiranes and aziridines efficiently undergo ring opening with bismuth nitrate at room temperature to furnish the corresponding β‐(nitrooxy)‐substituted alcohols and amines respectively. The conversions are highly regio‐ and stereoselective and afford the nitrooxy‐compounds in excellent yields within a short period of time.
Stereoselective Aldol Reactions Catalyzed by Acyclic Amino Acids in Aqueous Micelles
Authors: Deng Dong‐Sheng , Cai Jiwen 
Published: January 2007

AbstractThe catalytic properties of all proteinogenic, acyclic amino acids for direct aldol reaction in H2O, assisted by various surfactants, were investigated. The basic and neutral amino acids were shown to be efficient catalysts, giving rise to good‐to‐excellent yields of adducts (up to 95%), with moderate‐to‐good diastereoselectivities (up to 86%), L‐arginine being the most‐effective catalyst. The syn/anti diastereoisomer ratio could be readily tuned by proper choice of the amino acid used. Also, the range of substrates that underwent the reaction was extended to less‐reactive aldehydes carrying electron‐donating Br substituents.
Triterpenoids from the Leaves of Ilex hainanensis
Authors: Zhou Si‐Xiang , Yang Jun‐Shan , Liu Fu‐Cheng , Tu Peng‐Fei 
Published: January 2007

AbstractPhytochemical investigation on the leaves of Ilex hainanensis Merr. led to the isolation of four new ursane‐ and oleanane‐based triterpenoids, ilexhainanins A–D (1–4), as well as two known compounds, 2α,3β,19α‐trihydroxyurs‐12‐ene‐23,28‐dioic acid and 2α,3β,19α‐trihydroxyolean‐12‐ene‐23,28‐dioic acid. Their structures were elucidated on the basis of chemical and spectroscopic evidence, and by comparison with literature data.
Ring‐Opening Reactions of 3‐Aryl‐1‐benzylaziridine‐2‐carboxylates and Application to the Asymmetric Synthesis of an Amphetamine‐Type Compound
Authors: Manaka Tomoyuki , Nagayama Shin‐Ichiro , Desadee Wannaporn , Yajima Naoki , Kumamoto Takuya , Watanabe Toshiko , Ishikawa Tsutomu , Kawahata Masatoshi , Yamaguchi Kentaro 
Published: January 2007

AbstractNucleophilic ring‐opening reactions of 3‐aryl‐1‐benzylaziridine‐2‐carboxylates were examined by using O‐nucleophiles and aromatic C‐nucleophiles. The stereospecificity was found to depend on substrates and conditions used. Configuration inversion at C(3) was observed with O‐nucleophiles as a major reaction path in the ring‐opening reactions of aziridines carrying an electron‐poor aromatic moiety, whereas mixtures containing preferentially the syn‐diastereoisomer were generally obtained when electron‐rich aziridines were used (Tables 1–3). In the reactions of electron‐rich aziridines with C‐nucleophiles, SN2 reactions yielding anti‐type products were observed (Table 4). Reductive ring‐opening reaction by catalytic hydrogenation of (+)‐trans‐(2S,3R)‐3‐(1,3‐benzodioxol‐5‐yl)aziridine‐2‐carboxylate (+)‐trans‐3c afforded the corresponding α‐amino acid derivative, which was smoothly transformed into (+)‐tert‐butyl [(1R)‐2‐(1,3‐benzodioxol‐5‐yl)‐1‐methylethyl]carbamate((+)‐14) with high retention of optical purity (Scheme 6).
Synthesis of β‐Chlorohydrins in Water
Authors: Das Biswanath , Venkateswarlu Katta , Krishnaiah Maddeboina 
Published: January 2007

Abstract2,4,6‐Trichloro‐1,3,5‐triazine (TCT, cyanuric chloride) was found to mediate the regio‐ and stereoselective ring opening of epoxides in H2O in the presence of morpholine at room temperature to afford the corresponding β‐chlorohydrins in excellent yields (Table). The transformation is very simple, fast, efficient, and ecologically beneficial.