bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract SY39-03: Illuminating the tumor immune GPCRome: Novel immunotherapy targets
Authors: Gutkind J. Silvio 
Published: April 2024

Abstract
Immune checkpoint blockade (ICB) targeting PD-1 and CTLA-4 has revolutionized cancer treatment. However, many cancers do not respond to ICB, prompting the search for additional strategies to achieve durable cancer remission. In this regard, G-protein-coupled receptors (GPCRs) represent the largest family of cell surface receptors involved in signal transduction and are the target of &gt;30% of all approved drugs. GPCRs are the most pharmacologically favorable targets due to their druggability and direct relevance to many key physiological processes and a myriad of human diseases. However, GPCRs have been largely underexploited in oncology, and specifically understudied in cancer immunotherapy. GPCRs are primarily coupled to 4 distinct families of G proteins α subunit (Gαi, Gαs, Gαq, and Gα12), which dictate the signaling events controlled by each GPCR. Recently, we cross-integrated large single-cell RNA-sequencing datasets from CD8+ T cells covering 19 distinct cancer types and identified an enrichment of Gαs-coupled GPCRs on exhausted CD8+ T cells. These include GPCRs activated by inflammatory mediators, protons, neurotransmitters, and metabolites that accumulate in the tumor microenvironment, thereby promoting T cell dysfunction. We also developed transgenic mice expressing a chemogenetic CD8-restricted Gαs-GPCR and showed that a Gαs-PKA signaling axis promotes CD8+ T cell exhaustion and immunotherapy failure. These studies revealed that tumor cells may avoid immune elimination by stimulating Gαs-GPCRs on infiltrating CD8 T cells, thereby exposing novel druggable immune checkpoints that can be exploited therapeutically. We have recently extended these studies and mapped the expression patterns of all human GPCRs in nearly a million-tumor infiltrating immune cells. The emerging tumor-immune GPCR atlas may provide a valuable resource to explore the role of GPCRs in cancer immunology. Ultimately, our study may reveal new and exciting GPCR therapeutic targets to enhance the response to ICB, and help identify potential co-medications that may limit the success of ICB therapies.
Citation Format: J. Silvio Gutkind. Illuminating the tumor immune GPCRome: Novel immunotherapy targets [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 2 (Late-Breaking, Clinical Trial, and Invited Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(7_Suppl):Abstract nr SY39-03.
Lower Childhood Socioeconomic Status Is Associated with Greater Neural Responses to Ambient Auditory Changes in Adulthood
Authors: Hao Yu , Hu Lingyan 
Published: April 2024

Abstract
Humans' early life experience varies by socioeconomic status (SES), raising the question of how this difference is reflected in the adult brain. An important aspect of brain function is the ability to detect salient ambient changes while focusing on a task. Here, we ask whether subjective social status during childhood is reflected by the way young adults' brain detecting changes in irrelevant information. In two studies (total n = 58), we examine electrical brain responses in the frontocentral region to a series of auditory tones, consisting of standard stimuli (80%) and deviant stimuli (20%) interspersed randomly, while participants were engaged in various visual tasks. Both studies showed stronger automatic change detection indexed by MMN in lower SES individuals, regardless of the unattended sound's feature, attended emotional content, or study type. Moreover, we observed a larger MMN in lower-SES participants, although they did not show differences in brain and behavior responses to the attended task. Lower-SES people also did not involuntarily orient more attention to sound changes (i.e., deviant stimuli), as indexed by the P3a. The study indicates that individuals with lower subjective social status may have an increased ability to automatically detect changes in their environment, which may suggest their adaptation to their childhood environments.
An Unpredictable Brain Is a Conscious, Responsive Brain
Authors: Mofakham Sima , Robertson Jermaine , Lubin Noah , Cleri Nathaniel A. , Mikell Charles B. 
Published: April 2024

Abstract
Severe traumatic brain injuries typically result in loss of consciousness or coma. In deeply comatose patients with traumatic brain injury, cortical dynamics become simple, repetitive, and predictable. We review evidence that this low-complexity, high-predictability state results from a passive cortical state, represented by a stable repetitive attractor, that hinders the flexible formation of neuronal ensembles necessary for conscious experience. Our data and those from other groups support the hypothesis that this cortical passive state is because of the loss of thalamocortical input. We identify the unpredictability and complexity of cortical dynamics captured by local field potential as a sign of recovery from this passive coma attractor. In this Perspective article, we discuss how these electrophysiological biomarkers of the recovery of consciousness could inform the design of closed-loop stimulation paradigms to treat disorders of consciousness.
A Republic of Learning: Making for Times of Uncertainty
Authors: Jacobs Rachel , Lane Giles 
Published: April 2024

Abstract
Republic of Learning (RoL) was an experimental program bringing people together to learn about resilience in times of planetary health crisis, environmental change, and growing uncertainty. Eleven sessions took place between 2019 and 2022, planting seeds for an informal community to emerge with a unique approach to shared learning. RoL combined artistic craft-making with cooperative thinking—slowing down debate to sideline confrontations and argument in favor of more gentle forms of colearning and collaboration. This article explores the methods, outcomes, and opportunities that this process opens up for new forms of action and engagement with issues of climate change, resilience, and reciprocity.
All Watched Over by Our Data Double
Authors: Biggs Simon , Carvalho Ana 
Published: April 2024

Abstract
The term data double denotes information generated by and collected from users of networked communications to construct relational databases in marketing and other domains. Each subject (user) of this surveillance-panoptical system inevitably informs and objectifies all other subjects. Social media experiences are based on our continuously “tracked” engagement. Surveillance functions across written and spoken language, biometrics, geolocation, and visual and behavioral patterns. This text is primarily concerned with visual media and its production and (re)circulation as the accumulation of data through uploading, viewing, liking, commenting, remixing, and sharing. The article explores how selected media artists reflect upon the potential of recirculating information to reveal our data doubles and the surveillance-panoptical system.
DNA Dance Revolution
Authors: Cai Yiyu , Chen Jieqiong , Chan Wei Hao , Tan Ser Yang 
Published: April 2024

Abstract
This paper proposes to teach students biology through dance. Knowledge of nucleotides, amino acids, and structures of DNA and protein is used to create dance music and choreography. The three nucleotides (A, T, G, or C) making up the amino acids of selected proteins are converted into a musical note. In accordance with DNA’s double helix structure and base-pairing, the authors designed a low-cost, in-house Dance Dance Revolution (DDR) machine to allow for a dual player dance mode that requires students to synchronize their choreography during gameplay.
Auro Lecci’s Algorithmic Art: Toward the Computer as a Thinking Machine
Authors: Lagonigro Paola 
Published: April 2024

Abstract
This paper analyzes Italian artist Auro Lecci’s contribution to pioneering media art, beginning with his paintings and ending with his computer artworks (1969–1972). As the author suggests, Lecci’s paintings were already characterized by an algorithmic method that the artist went on to develop in his computer-generated works. The paper first discusses the plotter drawings Lecci created at the Computing Center of the University of Pisa (CNUCE), and then focuses on his last computer art project, made at the University of Massachusetts in Amherst, to suggest connections between Lecci’s work and artificial intelligence.
A 15-Year Retrospective on Immersive Visualization Lessons from the Applied Visualization Laboratory
Authors: Khadka Rajiv , Koudelka John 
Published: April 2024

Abstract
This paper shares the experiences of operating an immersive visualization laboratory over a 15-year period. The paper discusses valuable insights into the lessons learned from various projects, including the challenges they faced, such as technical difficulties, user adoption, and practical solutions for overcoming them. One crucial element for successful immersive visualization projects is interdisciplinary collaboration. The paper presents the advantages of immersive visualization technology, such as improved data comprehension, enhanced communication, and increased engagement in complex scenarios. We present the dynamic realm of virtual and augmented reality (VR/AR) technology in the context of an immersive laboratory system. We spotlight rising trends inside the integration of VR/AR tools for visualization. We also present our experience in dealing with the hardware and software additives in immersive VR/AR labs, shedding light on the demanding situations and successes encountered throughout everyday operations. Furthermore, we offer practical knowledge and guidance based on years of experience in the field, which can help you overcome challenges and achieve success in your project.
Insights into key threats and conservation status of the river lapwing, Vanellus duvaucelii (Lesson, 1826) in Northern India
Authors: Mishra Himanshu , Kumar Vikas , Bano Farah , Prateek  , Mishra Anshu , Kumar Ashish 
Published: April 2024

Abstract
The river lapwings are inhabitant of river banks with sand or gravel bars and river islands. In this study, we investigated vital threats (natural and anthropogenic) and the conservation status of river lapwing in the riverine ecosystem of Northern India. In this regard, we frequently visited selected study sites along the banks of the river Ganges in the district of Raebareli (Uttar Pradesh), India, from January 2016 to December 2019. To estimate perceived threats for river lapwing, we developed a questionnaire and collected threat scores. The line transect method was used to estimate the density of river lapwing. Predation and farming activities were the most potent threats influencing the survival and abundance of river lapwing. River lapwings were primarily observed at open unvegetated river banks and open unvegetated islands. They were seen in significant density near the water in the breeding season. We concluded that the population of river lapwing is relatively stable in the Gangetic plains of Northern India. However, it is declining in other parts of the world, for example, in Southern Laos. Though it is a relatively common species, robust scientific information about its population and habitat relation is mainly absent. Therefore, accurate counts from other parts of the world are needed to place the estimate for river lapwing into a comprehensible, inclusive perspective. Furthermore, detailed information on habitat relationships is also necessary to develop conservation strategies.
Energetics and Transfer of Submesoscale Brine-Driven Eddies at a Sea Ice Edge
Authors: Lo Piccolo Anna , Horvat Christopher , Fox-Kemper Baylor 
Published: April 2024

Abstract
During polar winter, refreezing of exposed ocean areas results in the rejection of brine, i.e., salt-enriched plumes of water, a source of available potential energy that can drive ocean instabilities. As this process is highly localized, and driven by sea ice physics, not gradients in oceanic or atmospheric buoyancy, it is not currently captured in modern climate models. This study aims to understand the energetics and lateral transfer of density at a semi-infinite, instantaneously opened, and continuously refreezing sea ice edge through a series of high-resolution model experiments. We show that kilometer-scale submesoscale eddies grow from baroclinic instabilities via an inverse energy cascade. These eddies meander along the ice edge and propagate laterally. The lateral transfer of buoyancy by eddies is not explained by existing theories. We isolate the fundamental forcing-independent quantities driving lateral mixing and discuss the implications for the overall strength of submesoscale activity in the Arctic Ocean.
Growing the Next Generation of Nurse Leaders: A Report of the Process and Outcomes of the Midwest Nursing Research Society Leadership Academy
Authors: Adeola Mopelola T. , Fink Anne M. , Shen Qiuhua , Souza-Talarico Juliana N. , Timm Jennifer , Anderson Cindy M. , Buckwalter Kathleen 
Published: April 2024

Background: Leadership development, career advancement, and collaboration among scholars are essential to nurturing nursing research excellence and sustainability. The Midwest Nursing Research Society (MNRS) has incorporated several strategies to advance nursing science and to increase the pool of future nurse leaders. In this article, we describe the process, activities, and outcomes of the Leadership Academy (LA), an innovative initiative from MNRS developed to identify, engage, and nurture future generations of leaders. Methods: For the LA 2022 to 2023 period, the MNRS leaders selected a cohort of 5 nurse scholars and engaged them in activities to develop, enhance, and advance their leadership skills. By following the LA purposes, the cohort participated in monthly meetings with MNRS leaders, received individual mentoring sessions, assessed strengths and areas for further development, attended seminars, participated in a book club, and implemented a cohort project that focused on the promotion and support of early career scholars. Results: Outcomes showed increased knowledge about organizational governance, direction, and resource development; leadership confidence culminating with leadership positions inside and outside MNRS; career development plans; engagement with board members, and enhanced networking. Moreover, the cohort members planned and executed a well-attended conference special session that engaged a large group of scholars to discuss challenges and opportunities for career development at the MNRS Annual Conference. Conclusion: The MNRS LA is a thriving organizational initiative that promotes engagement and leadership skills development thereby increasing the pool of candidates confidently prepared to lead the nursing profession.
Physical Activity and Local Blue/Green Space Access During the COVID-19 Pandemic
Authors: Nicklett Emily J. , Sharma Bonita B. , Testa Alexander 
Published: April 2024

Purpose To examine whether local blue and green space access was associated with weekly physical activity frequency during the COVID-19 pandemic. Design Cross-sectional. Setting Population-based, nationally representative sample of U.S. adults (May and June 2021). Sample Adults, ages 18-94 (N = 1,771). Measures Self-reported data included the presence of blue spaces (e.g., lakes, outdoor swimming pools, riverside trails) and green spaces (e.g., parks, forests, or natural trails) in their neighborhoods, and days of physical activity per week (e.g., running, swimming, bicycling, lifting weights, playing sports, or doing yoga). Analysis Multiple Poisson regression assessed relationships between blue and green spaces and physical activity, with coefficients transformed into incidence risk ratios (IRR). Results Among participants, 67.2% reported living near a blue space and 86.1% reported living near a green space. Racial/ethnic and socioeconomic disparities in access to blue and green spaces were observed, with less access among non-Hispanic Black participants and those with lower income and educational attainment. Living near blue (IRR = 1.23, 95% CI = 1.10, 1.39) or green space (IRR = 1.25, 95% CI = 1.02, 1.54) was significantly associated with more frequent weekly physical activity. Conclusion Proximity to blue or green spaces is associated with more frequent physical activity during the COVID-19 pandemic. Health promotion efforts should include equitable strategies to improve accessibility to blue and green spaces.
Personal dignity in people with early-stage dementia: A longitudinal study
Authors: Kisvetrová Helena , Bretšnajdrová Milena , Jurašková Božena , Langová Kateřina 
Published: April 2024

Background A psychosocial problem faced by people with early-stage dementia (PwESD) is the perception of threats to personal dignity. Insights into its dynamics are important for understanding how it changes as dementia advances and to develop suitable interventions. However, longitudinal studies on this change in PwESD are lacking. Aims To determine how perceptions of dignity and selected clinical and social factors change over 1 year in home-dwelling PwESD and the predictors associated with changes in perceptions of dignity over 1 year. Research design and methods A longitudinal study was conducted. The sample included 258 home-dwelling Czech PwESD. Data were collected using the Patient Dignity Inventory (PDI-CZ), Mini-Mental State Examination, Bristol Activities of Daily Living Scale, Geriatric Depression Scale and items related to social involvement. Questionnaires were completed by the PwESD at baseline and after 1 year. Ethical considerations The study was approved by the ethics committee and informed consent was provided by the participants. Results People with Early-Stage Dementia rated the threat to dignity as mild and the ratings did not change significantly after 1 year. Cognitive function, self-sufficiency, vision, and hearing worsened, and more PwESD lived with others rather than with a partner after 1 year. Worsened depression was the only predictor of change in perceived personal dignity after 1 year, both overall and in each of the PDI-CZ domains. Predictors of self-sufficiency and pain affected only some PDI-CZ domains. Conclusions Perceptions of threat to dignity were mild in PwESD after 1 year, although worsened clinical factors represented a potential threat to dignity. Our findings lead us to hypothesise that perceived threats to personal dignity are not directly influenced by health condition, but rather by the social context.
Worsening of early DME after cataract surgery. The DICAT II Study report #2
Authors: Pastore Marco R. , Vinciguerra Alex Lucia , Mura Giulia Dalla , Jabali Abdallah El , Tognetto Daniele , Panozzo Giacomo 
Published: April 2024

Purpose To analyse the long anatomical and functional outcome of a subgroup of the DICAT II study cohort, consisting of 26 patients undergoing cataract surgery and withdrawn from the study for a clinically significant worsening of early diabetic macular edema (DME). Materials Patients who underwent cataract surgery and withdrawn from the DICAT II study for a clinically significant worsening of early DME with at least 12 months follow–up after the dropout. The study population was divided into two groups according to the clinical evaluation at one-year follow-up: ongoing treatment patients for DME (Treatment group, TG) and patients no longer treated (Non Treatment group, NTG). Results Central foveal thickness (CFT) at baseline and dropout time were higher in TG than in the NTG, with a statistically significant difference ( p < 0.05). In addition, TG patients reported a higher levels of glycated hemoglobin at time baseline compared to NTG patients (7.81 ± 1.15 vs 7.02 ± 0.56; p = 0.048). The linear regression analysis demonstrated a statistically significant relationship between the visual acuity and the ongoing treatment group at one-year follow-up (p = 0.042). Conclusion The study provides parameters to be considered when assessing the risk of developing persistent DME after cataract surgery in diabetic patients. In particular, CFT at baseline and dropout time have been reported to be an effective and predictable OCT biomarkers when evaluating DME progression. During the evaluation of the systemic disease, similar results were found for the glycated hemoglobin at baseline.
Sociodemographic and Behavioral Factors Associated With Hypertension and Depression in 4 Rural Communities in Northern Ghana: A Cross-Sectional Study
Authors: Babagoli Masih A. , Adu-Amankwah Dorothy , Nonterah Engelbert A. , Aborigo Raymond A. , Kuwolamo Irene , Jones Khadija R. , Alvarez Evan E. , Horowitz Carol R. , Weobong Benedict , Heller David J. 
Published: April 2024

Objectives: The prevalences of hypertension and depression in sub-Saharan Africa are substantial and rising, despite limited data on their sociodemographic and behavioral risk factors and their interactions. We undertook a cross-sectional study in 4 communities in the Upper East Region of Ghana to identify persons with hypertension and depression in the setting of a pilot intervention training local nurses and health volunteers to manage these conditions. Methods: We quantified hypertension and depression prevalence across key sociodemographic factors (age, sex, occupation, education, religion, ethnicity, and community) and behavioral factors (tobacco use, alcohol use, and physical activity) and tested for association by multivariable logistic regression. Results: Hypertension prevalence was higher in older persons (7.6% among 35- to 50-year-olds vs 16.4% among 51- to 70-year-olds) and among those reporting alcohol use (18.9% vs 8.5% between users and nonusers). In multivariable models, only older age (AOR 2.39 [1.02, 5.85]) and residence in the community of Wuru (AOR 7.60 [1.81, 32.96]) were independently associated with hypertension, and residence in Wuru (AOR 23.58 [7.75-78.25]) or Navio (AOR 7.41 [2.30-24.74]) was the only factor independently associated with depression. Conclusions: We report a high prevalence of both diseases overall and in select communities, a trend that requires further research to inform targeted chronic disease interventions.
Bone marrow niches for hematopoietic stem cells: life span dynamics and adaptation to acute stress
Authors: Hofmann Johanna , Kokkaliaris Konstantinos D. 
Published: April 2024

Abstract
Hematopoietic stem cells (HSCs) are instrumental for organismal survival because they are responsible for lifelong production of mature blood lineages in homeostasis and response to external stress. To fulfill their function, HSCs rely on reciprocal interactions with specialized tissue microenvironments, termed HSC niches. From embryonic development to advanced aging, HSCs transition through several hematopoietic organs in which they are supported by distinct extrinsic cues. Here, we describe recent discoveries on how HSC niches collectively adapt to ensure robust hematopoietic function during biological aging and after exposure to acute stress. We also discuss the latest strategies leveraging niche-derived signals to revert aging-associated phenotypes and enhance hematopoietic recovery after myeloablation.