bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preoperative diagnostic accuracy of fine‐needle aspiration in the management of breast lesions: Comparison of specificity and sensitivity with clinical examination, mammography, echography, and thermography in 249 patients
Authors: Negri Stefano , Bonetti Franco , Capitanio Arrigo , Bonzanini Mariella 
Published: February 2007

AbstractTwo hundred and forty‐nine women suffering from breast problems underwent a complete series of tests including clinical examination, mammography, echography, thermography, and fine‐needle aspiration (FNA). Ninety‐four of these patients were shown to be positive or to have suspected malignancy. Accordingly, they underwent surgical excision followed by histologic examination, while the remaining patients were re‐examined after 12 to 18 mo in order to exclude false negatives.The analysis of specificity and sensitivity of every single procedure showed that FNA describes the best degree of sensitivity and specificity but no procedure allows, by itself, the detection of all carcinomas. When considered in combination, clinical examination, mammography, and fine‐needle aspiration have a sensitivity of 100% and a specificity of 49%, and are the best diagnostic tests for a correct assessment of mammary lesions. Thermography and echography showed a low degree of sensitivity and should not be included in the routine diagnostic procedure of breast lesions. Diagn Cytopathol 1994; 11:4–8. © 1994 Wiley‐Liss, Inc.
Occult breast lesions and aspiration biopsy: The lankenau experience
Authors: Zemba‐Palko Vlasta , Minkowitz Gerald , Kline Tilde S. 
Published: February 2007

AbstractWith the increased use of screening mammography, many occult lesions are being identified. Despite the availability of ultrasonography and stereotaxis, their use in conjunction with fine‐needle aspiration biopsy for further examination of these lesions, at the time when cost containment is a serious consideration, must be evaluated. Consequently, the role of cytopathologist becomes important in identifying lesions requiring timely follow‐up and surgical treatment.To assist the clinicians in evaluating the best approach to occult lesions, we reviewed the results from ultrasonographic guided aspiration biopsies (100) and stereotactic guided aspiration biopsies (61) at our institution. Our findings and review of the literature suggest that the former should only be used sparingly. By contrast, stereotactic biopsies interpreted as a part of an interdisciplinary approach can provide critical information for decision‐making. Diagn Cytopathol 1994; 11:15–19. © 1994 Wiley‐Liss, Inc.
Efficacy of thinprep® preparation of cervical smears: A 1,000‐case, investigator‐sponsored study
Authors: Awen Charles , Hathway Stephen , Eddy William , Voskuil Roy , Janes Charmayne , Hutchinson Martha 
Published: February 2007

AbstractThe diagnoses of 1,000 pairs of conventional Papanicolaou (Pap) smears and ThinPrep® preparations were compared. Cervical cells were collected using an Ayre spatula and endocervical brush. The conventional smear was made first, the collection devices were rinsed into PreservCyt® solution, and the slides were prepared using the ThinPrep® Processor. The diagnoses of the paired smears agreed in 988 of the 1,000 cases (98.8%), including 949 negatives, 28 atypicals, 9 low grade squamous intraepithelial lesions (LGSIL), and 2 high grade squamous intraepithelial lesions (HGSIL). Five cases where LGSIL or HGSIL was found on the ThinPrep® slide were negative or atypical on the conventional smear. No conventional smear abnormalities were missed on the ThinPrep® slide. Although not statistically significant, this difference indicates that the ThinPrep® method gives a better diagnosis of abnormalities than the conventional method. The ThinPrep® method was acceptable to participating physicians and ThinPreps® were easier and faster to screen than conventional smears. Diagn Cytopathol 1994; 11:33–37. © 1994 Wiley‐Liss, Inc.
Fine‐needle aspiration cytology of salivary duct carcinoma
Authors: Elsheikh Tarik M. , Bernacki Edward G. , Pisharodi Latha 
Published: February 2007

AbstractSalivary duct carcinoma (SDC) is an extremely rare and highly aggressive primary epithelial neoplasm of the salivary glands associated with increased tendency for lymph node and vascular metastases. Histologically, this lesion resembles intraductal cribri‐form and comedo carcinoma of the breast. Fine‐needle aspiration (FNA) cytology of SDC in two patients with parotid masses (ages 65 and 67) is presented. The aspirates were sparsely to richly cellular and contained predominantly broad flat and branching sheets of large polygonal epithelial cells with abundant eosinophilic cytoplasm, round to oval nuclei, finely granular chromatin and prominent nucleoli. Few sheets showed cribriforming and papillary configuration. The cytologic differential diagnosis included oncocytoma, acinic cell carcinoma, muco‐epidermoid carcinoma, and melastatic adenocarcinoma. To the best of our knowledge, this is the first report to describe a spectrum of cytologic features that may allow a specific FNA diagnosis of SDC. Preoperative diagnosis of this neoplasm may warrant a more extensive radiologic workup and therapy including radical surgery and neck dissection followed by radiation therapy. Diagn Cytopathol 1994; 11:47–51. © 1994 Wiley‐Liss, Inc.
Hypersegmentation of neutrophils in the cerebrospinal fluid: Report of a case with hematologic correlation and review of the literature
Authors: Lodge‐Rigal R. Daniel , Novotny Debra B. 
Published: February 2007

AbstractHypersegmented neutrophils can occasionally be seen in the cere‐brospinal fluid (CSF) of patients with acute pyogenic meningitis, and rarely as an artifact of cytocentrifugation. We report a case of florid neutrophil hypersegmentation in cytocentrifuged CSF specimens from a patient presenting with anemia and mental status changes. Megaloblastic anemia was excluded by a thorough hematologic evaluation, and the patient was later found to have an epidural abscess. The striking hypersegmentation is attributed to the combined effects of meningeal infection and cytocentrifugation, and a review of the available limited literature on cytomorphologic alterations in CSF cells, specifically neutrophils, is presented. Diagn Cytopathol 1994; 11:56–59. © 1994 Wiley‐Liss, Inc.
Fine‐needle aspiration biopsy of pituitary carcinoma with cervical lymph node metastases: A report of two cases and review of the literature
Authors: Cartwright David M. , Miller Theodore R. , Nasr Anthony J. 
Published: February 2007

AbstractMetastases from pituitary carcinomas are rare lesions that can mimic other tumors on fine‐needle aspiration biopsies. Two patients with primary pituitary neoplasms developed cervical lymph node metastases, which were sampled and diagnosed correctly using the fine‐needle aspiration biopsy technique. These two cases demonstrate the varied cytologic patterns of pituitary neoplasms, ranging from uniform bland cells to cells with striking anaplastic features. The time period between the onset of symptoms and subsequent metastases is unpredictable as well, underscoring the need for an accurate clinical history before a meaningful cytologic interpretation is made. Diagn Cytopathol 1994; 11:68–73. © 1994 Wiley‐Liss, Inc.
Fine‐needle aspiration biopsy of renal collecting duct carcinoma
Authors: Layfield Lester J. 
Published: February 2007

AbstractThe fine‐needle aspiration biopsy (FNA) findings in a case of collecting duct (ducts of Bellini) carcinoma of the kidney are described. The cytologic smears were modestly cellular and contained individual and small clusters of round to oval cells with small to moderate amounts of well‐defined cytoplasm. The nuclei were large and hyperchromatic with prominent single nucleoli and focal chromatin clearing. The findings were distinct from those of the usual clear or granular cell renal‐cell carcinomas and were more similar to adenocarcinomas arising in the breast, ovary, or pancreas. Because collecting duct carcinomas need to be distinguished from metastatic deposits and are believed to have a poorer prognosis than the majority of renal‐cell carcinomas, preoperative diagnosis may have important therapeutic implications. The distinction of collecting duct carcinoma from the more common variants of renal‐cell carcinoma and transitional‐cell carcinoma is discussed. Diagn Cytopathol 1994; 11:74–78. © 1994 Wiley‐Liss, Inc.
Artifactual endocervical atypia induced by endocervical brush collection
Authors: Fiorella Russell M. , Casafrancisco Don , Yokota Susan , Kragel Peter J. , Davey Diane D. 
Published: February 2007

AbstractThe cytologic distinctions between artifactual atypia induced by endocervical brush collection, endocervical glandular repair, and endocervical glandular dysplasia or neoplasia are often difficult. This difficulty is amplified by the lack of accepted cytologic criteria for endocervical glandular dysplasia, and the fact that earlier studies defining the significant cytologic features of endocervical adenocarcinoma in situ and endocervical adenocarcinoma (endocervical neoplasia) utilized a swab for endocervical cell retrieval. With the almost universal adoption of the endocervical brush, it is important to redefine those cytologic characteristics that differentiate true endocervical glandular dysplasia or neoplasia from reactive or reparative processes and instrument artifact.From our data, it appears that the classically described cytologic discriminators between a negative smear and smears of endocervical dysplasia or neoplasia are basically unchanged with some minor modifications for endocervical brush‐collected samples. Diagn Cytopathol 1994; 11:79–84. © 1994 Wiley‐Liss, inc.
Laboratory compliance with federal government and professional society recommendations
Authors: Layfield Lester J. , Zaleski Sue , Bottles Kent , Cohen Michael B. 
Published: February 2007

AbstractQuality assurance issues have assumed growing importance in the cytology laboratory. The 1988 Clinical Laboratories Improvement Amendment (CLIA '88) (United States Department of Health and Human Services, Federal Register: U.S. Government Printing Office 1990;55:9495) regulates the patient identifiers and clinical data on the requisition form but does not mandate physician compliance to provide the information. We investigated the use of patient identifiers and clinical data by laboratories as specimen acceptance/rejection criteria. We surveyed 81 board certified cytopathologists and 235 randomly selected cytology laboratories for acceptance criteria of cytology specimens and received responses from 104. Approximately two thirds of all responding laboratories had specific criteria for rejecting specimens on the basis of inadequate identification or clinical data. While the vast majority required the specimens to be identified with patient name, collection date, and specimen source, a minority of laboratories required clinical information such as LMP, prior atypical cytologic/histologic specimens, and history of previous therapy. Little correlation was found between practice setting and the use of rejection criteria. Diagn Cytopathol 1994; 11:85–92. © 1994 Wiley‐Liss, Inc.
Fine‐needle aspiration of plasma cell disorders: Special emphasis on plasma cell subtype
Authors: Karmakar Tarun , Dey Pranab 
Published: February 2007

AbstractFine‐needle aspiration cytology and clinical presentations of 16 cases of plasma cell dyscrasias (PCD) have been studied in a period of 6 yr. There were seven cases of solitary plasmacytomas of bones, two cases of extramedullary plasmacytomas, and seven cases of multiple myelomas. Differential counts of mature and immature plasma cells along with presence of cell clumps, mitosis, and bi/multinucleations were studied. The cytological findings revealed no correlation with the different subtypes of PCDs; however, it was helpful in the differential diagnosis. Bone narrowing findings, immunological parameters, available histopathology, and X‐ray appearances were analysed. Clinical diagnosis of PCDs were made in only three cases. Thus fine‐needle aspiration biopsy was considered as an important diagnostic modality in tissue diagnosis of plasma cell tumors, particularly in solitary plasmacytoma of bone and extramedullary plasmacytoma. Diagn Cytopathol 1994; 11:119–123. © 1994 Wiley‐Liss, Inc.
Comparative study of interphase cytogenetics, flow cytometric analysis, and nuclear grade of fine‐needle aspirates of breast carcinoma
Authors: Cajulis Ricardo S. , Kotliar Sophia , Haines George K. , Frias‐Hidvegi Denise , O'Gorman Maurice 
Published: February 2007

AbstractThe correlation between DNA ploidy and S‐phase fraction (SPF) by flow cytometry (FCM) and the detection of numerical chromosomal abnormalities (NCA) by interphase cytogenetics (IC) involving chromosomes 8 and 12 was studied in 20 human breast lesions (17 breast carcinomas, 2 fibroadenomas, and 1 sclerosing adenosis). Initial diagnosis was performed on fine‐needle aspiration biopsy (FNAB) material with subsequent histologic confirmation. FCM was performed on formalin‐fixed paraffin‐embedded tissue while IC by fluorescence in situ hybridization (FISH) was done on alcohol fixed FNAB materials. Sixteen (80%) cases showed concordance between FCM and IC with respect to the presence or absence of aneuploidy. The remainder of the cases (20%), which were all malignant neoplasms, showed discrepancies between the two methods, all four were DNA‐diploid with low SPF by FCM but showed various NCA by IC. Nuclear grades (NG) of all the malignant samples were also evaluated and correlated with both FCM and IC studies. Although a good correlation was observed between NG and FCM, a better correlation was seen between NG and IC. This study shows that although IC by FISH correlated well with FCM analysis, it can detect NCA in DNA‐diploid, low SPF tumors. It also correlates well with the NG of the tumor. The increased sensitivity provided by IC in detecting aneuploidy may be of great prognostic significance in low stage, DNA‐diploid, low SPF breast carcinomas. Diagn Cytopathol 1994; 11:151–158. © 1994 Wiley‐Liss, Inc.
Small round cell tumor with divergent differentiation: Cytologic, histologic, and ultrastructural findings
Authors: Akhtar Mohammed , Ali Muhammad Ashraf , Sabbah Rajeh , Bakry Mohammed , Al‐Dayel Fouad 
Published: February 2007

AbstractA case study of desmoplastic small round cell tumor with divergent differentiation in a 13‐yr‐old boy is presented. Clinical, cytologic, histologic, immunohistochemical, and ultrastructural findings are reported. There was a close correlation between the various histologic and cytologic patterns. Immunohistochemical studies revealed strong positivity of many of the tumor cells for cytokeratin, vimentin, and desmin. Ultrastructurally, some of the tumor cells contained aggregates of cytoplasmic intermediate filaments. Fine‐needle aspiration biopsy may suggest the diagnosis of desmoplastic small round cell tumor. Confirmation of the diagnosis may be provided by immuhistochemistry and electronmicroscopy. Diagn Cytopathol 1994; 11:159–164. © 1994 Wiley‐Liss, Inc.
Expression of the pS2 protein and correlation with estrogen receptor status in fine‐needle aspirates from breast carcinomas
Authors: Sauer Torill , Naess Oddvar 
Published: February 2007

AbstractA series of 36 cases of breast carcinomas diagnosed by fine‐needle aspiration were investigated for the presence of estrogen receptors (ER) and the estrogen‐induced pS2 protein. Immunocytochemically ER could be demonstrated in 28 aspirates, whereas eight were negative. These eight were also negative for the pS2 protein. In addition three aspirates with a low score for ER and five with a high score for ER were found negative for pS2. Thus, of the 36 cases, 20 were found to express the pS2 protein. The presence of the pS2 protein in the tumor cells is believed to be a marker of a functional estrogen regulatory system and its demonstration may therefore predict clinical responsiveness to hormonal therapy. Diagn Cytopathol 1994;11:165–167. © 1994 Wiley‐Liss, Inc.
Cytodiagnosis of a primary non‐Hodgkin's lymphoma of bone
Authors: Ascoli Valeria , Facciolo Francesco , Nardi Francesco 
Published: February 2007

AbstractWe report fine‐needle aspiration cytology and histologic findings of a primary non‐Hodgkin's lymphoma of bone involving the rib and iliac bones. Smears contained abnormal lymphoid cells and abundant lymphoglandular bodies, suggesting a malignant lymphoproliferative disease. However, histologic sections showed nests of tumor cells with extensive cytoplasmic clearing surrounded by sclerosis, thus mimicking a carcinoma. Clinical data, radiographic findings, and cytohistological correlation led to a final diagnosis of primary non‐Hodgkin's lymphoma of the bone, confirmed by immunopositive staining for leukocyte common antigen CD45 and B‐cell associated antigen CD20. It is concluded that finding numerous lymphoglandular bodies in bone tumor specimens allows an accurate diagnosis of lymphoid tissue. The rarity of bone lymphoma and the misleading histologic features can cause considerable difficulty in diagnosing this entity. The importance of identifying lymphoglandular bodies and the appropriate use of immunochemistry are emphasized. Diagn Cytopathol 1994;11:168–173. © 1994 Wiley‐Liss, Inc.
Infarcted intraduct papilloma diagnosed by fine‐needle biopsy: A cytologic, clinical, and mammographic pitfall
Authors: Greenberg Merle L. , Middleton Pip D. , Bilous A. Michael , Wilbur David C. 
Published: February 2007

AbstractNecrosis is a worrisome cytologic feature in breast aspirates which, when paired with suspicious clinical and mammographic findings, could potentially result in a false positive diagnosis. A 66‐yr‐old female presented with clinical evidence of stage 1 breast carcinoma supported by the mammographic and ultrasound findings. A fine‐needle biopsy (FNB) revealed extensive necrosis with scattered degenerate columnar cells, occasional clusters of hyperchromatic epithelial cells, and a few sheets of ductal cells. A cytologic diagnosis of an infarcted intraduct papilloma was made. This uncommon diagnosis was subsequently confirmed by open biopsy. Cytologic features to distinguish infarcted, necrotic, and papillary breast lesions are discussed. Diagn Cytopathol 1994;11:188–194. © 1994 Wiley‐Liss, Inc.
Morphologic and morphometric features of low grade serous tumours of the ovary
Authors: Gurley A. Marion , Hidvegi Denise F. , Cajulis Ricardo S. , Bacus Sarah 
Published: February 2007

AbstractPeritoneal washings from twelve patients with serous tumours of the ovary were studied. Six patients had borderline serous tumours (BSTs), and six had grade one adenocarcinomas. Papanicolaou stained slides were assessed for nine morphologic parameters; background, single cells, size of papillary fragments, contour of papillary fragments, psamomma bodies, cytoplasmic vacuoles, nuclear pleomorphism, nuclear membrane contour, and nucleoli The slides were destained and restained by the Feulgen method for assessment, with a computer based image analysis system (CAS100, Cell Analysis Systems, Inc., Elmhurst, IL), of DNA content, nuclear size, and nuclear roundness.The contour of the papillary fragments (P = 0.004) and the presence of nuclear pleomorphism (0.019) were distinguishing characteristics. All six BSTs were diploid while three of the six adenocarcinomas had aneuploidy. Two exhibited polyploid DNA distribution and one exhibited diploid DNA distribution. The pooled data for the nuclear size and roundness showed little difference in the modal values, although the nuclei of the adenocarcinoma cells were slightly larger than those of the borderline cells (54 sq. μm vs. 46 sw. μm). However, the coefficients of variation (CVs) for each of these parameters were larger in the adenocarcinoma group than in the borderline group (59.7 vs. 36.4% for size and 33.5 vs. 17.8% for roundness).Although the sample size is small, the data suggest that aneuploidy is rare in borderline tumours. In addition, the presence of papillary groups with irregular contours and nuclear pleomorphism (reflected in higher CVs for nuclear size and roundness) both occur more commonly in adenocarcinomas than in borderline tumours and may be of predictive value in distinguishing the two groups. Diagn Cytopathol 1994; 11:220–225. © 1994 Wiley‐Liss, Inc.
Immunocytochemical staining of c‐erbB‐2 oncogene in fine‐needle aspirates of breast carcinoma: A comparison with tissue sections and other breast cancer prognostic factors
Authors: Corkill Mary E. , Katz Ruth 
Published: February 2007

AbstractThe role of fine‐needle aspiration (FNA) in breast cancer management is expanding to include prognostic in addition to diagnostic studies. This study was undertaken to compare the immunohistochemical staining of c‐erbB‐2, a breast cancer prognostic factor, on cytologic FNA smears of breast cancer with that on corresponding formalin‐fixed, paraffin‐embedded tissue sections of the same tumor and to correlate the c‐erbB‐2 expression with other known breast cancer prognostic factors. FNA smears (destained, alcoholfixed, Pap‐stained direct smears) and corresponding tissue sections (formalin‐fixed, paraffin‐embedded, unstained sections) from 36 primary breast carcinomas were stained immunohistochemically with c‐erbB‐2 antibody using an avidin‐biotin procedure. Ten tumors (28%) showed strong positive staining for c‐erbB‐2 on the FNA smear and, of those ten, seven were positive on the corresponding tissue section and three were negative. In several of the cytology and tissue positive cases, staining on the tissue section was significantly weaker than on the FNA smear. Two cases involved treatment with preoperative chemotherapy; in one of those cases, tissue staining was weaker than cytologic staining, and, in the other case, both were negative. Correlation of c‐erbB‐2 staining with other prognostic factors showed an association between positive c‐erbB‐2 staining and high nuclear grade. Our results indicate that immunohistochemical staining for c‐erbB‐2 can be performed on destained FNA smears of breast carcinomas and may be more sensitive on the cytologic specimens than on formalin‐fixed, paraffin‐embedded tissue sections. Diagn Cytopathol 1994;11:250–254. © 1994 Wiley‐Liss, Inc.
Diagnosing intramuscular myxoma by fine‐needle aspiration: A multidisciplinary approach
Authors: Caraway Nancy P. , Staerkel Gregg A. , Fanning Christina V. , Varma Datla G. , Pollock Raphael E. 
Published: February 2007

AbstractThe gross and microscopic appearances of aspirates from ten intramuscular myxomas are reported. The specimens were obtained from seven women and three men, ages 43 to 75, who had tumors involving the muscles of the thigh (7), upper arm (2), and forearm (1). Magnetic resonance (MR) imaging performed in six of the ten cases revealed well‐defined, sharply demarcated tumors exhibiting low signal intensity relative to muscle on the T1‐weighted images. The tumors were hyperintense to muscle on T2‐weighted images. All aspirated tissues were clear, tenacious, and viscous. Smears contained few spindled and histiocytoid cells in an abundant mucoid background. Spindle cells demonstrated long cytoplasmic processes that in areas intertwined to form fibrillar tangles. Nuclei were oval to spindled with fine chromatin and inconspicuous nucleoli. Capillaries were sparse with simple (nonplexiform) branching. The differential diagnosis of myxoid lesions of the extremities includes benign entities such as myxoid schwannoma and neurofibroma, mesenchymal repair, and ganglion cyst, as well as malignant neoplasms such as myxoid liposarcoma, fibrosarcoma, malignant fibrous histiocytoma, and extraskeletal chondrosarcoma. The findings of this study revealed that, although the cytologic features were suggestive of intramuscular myxoma, a definitive diagnosis was often difficult, owing to scant cellularity and lack of distinctive cytologic features. The MR imaging findings may be utilized as an adjunct to the cytologic features to more confidently suggest a diagnosis of intramuscular myxoma. Diagn Cytopathol 1994;11:255–261. © 1994 Wiley‐Liss, Inc.