bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of public awareness and perspectives towards adverse drug reaction reporting system in Karachi, Pakistan
Authors: Iffat Wajiha , Shakeel Sadia , Nesar Shagufta , Qamar Ambreen , Huma Zille , Rehman Hina , Akhtar Mahwish , Ali Syed Ahsan , Ansari Mohammad Nadeem , Yaqoob Muhammad , Tariq Areeb Bin 
Published: February 2025

Background
Public involvement in reporting adverse drug reactions (ADRs) generates a broader database on drug safety. Underreporting remains a hindrance to implementing an effective pharmacovigilance system that ultimately affects public health. Hence, it is critical to appraise the public’s awareness of ADR reporting and pharmacovigilance to address the gaps for the enhancement of ADR reporting rate.

Objectives
The current study explored public knowledge and attitudes toward ADR reporting in Karachi, Pakistan.

Methods
A quantitative cross-sectional study was conducted from 3rd Jan 2022 to 30th Nov 2022 using a forty-item questionnaire to evaluate public insights regarding the ADR and its reporting. Descriptive analysis was executed to determine frequencies and percentages for the respondents’ baseline characteristics and the responses toward ADR reporting. The chi-square test (χ2) was applied to determine the association between the dependent and independent variables considering a p-value < 0.05 as statistically significant.

Results
The response rate of the present study was 78.3%. More than 80% of the respondents deemed that ADR occurs only with high doses of medicines and over-the-counter medications do not cause any ADR. More than 75% of the respondents did not know that the ADR reporting form is available on the Drug Regulatory Authority of Pakistan (DRAP) website; the response varied significantly with the education (p = 0.002) and social status (p = 0.0001) of the respondents. More than 50% of the participants refused to ever report an ADR to health professionals. Physicians (n = 364; 47.7%) and pharmacists (n = 253; 33.1%) were the respondents’ professed most reliable sources to whom ADR can be reported; responses varied significantly with their education (p = 0.003) and age (p = 0.001).

Conclusions
The study has provided insight into the challenges and gaps needed to improve ADR reporting in Pakistan. The outcomes revealed that the public is aware of the benefits of reporting ADRs; however, they do not realize their role and the potentially significant impact on the healthcare system by contributing to ADR reporting. Therefore, it is a need of time to educate the public on the value of reporting ADRs and implement user-friendly and accessible ADR reporting systems in patient care areas to facilitate easier reporting.
Characterizing pre-discharge interventions to reduce length of stay for older adults: A scoping review
Authors: Garcia Emily , Hass Zachary J. 
Published: February 2025

Background
Hospital pre-discharge interventions are becoming one of the leading strategies to promote early discharge. For older adult patients, it remains unclear what these interventions are and how they affect discharge outcomes.

Objective
This scoping review categorizes pre-discharge interventions promoting early acute care hospital discharging or total hospital length of stay reductions among older adults, synthesizes contextual factors (e.g., cost, staffing) driving implementation, and assesses the perceived intervention’s impact.

Design
The review followed the five states of the Arksey and O’Malley framework and the PRISMA-ScR extension. The PubMed, Embase, and Scopus databases were searched from 1983 to 2020 for pre-discharge interventions designed or adapted to discharge older adults earlier in their stay from acute care hospitals. Potentially relevant articles were screened against eligibility criteria. Findings were extracted and collated in data charting forms followed by brief thematic analyses.

Results
The search yielded 5,455 articles of which 91 articles were included. Eight pre-discharge intervention categories were identified: clinical management, diagnostic/risk assessment tools, staffing enhancements, drug administration, length of stay protocols, nutrition planning, and communication improvements. Leading motivations for intervention implementation included the nationwide drive to reduce care costs and hospitals’ need to increase hospital profitability, improve quality of care, or optimize resource utilization. Discharge outcomes reported included hospitalization costs, readmission rates, mortality rates, resource utilization rates and costs, and length of stay. Mixed results were found regarding the effectiveness of early discharge interventions on discharge outcomes based on expressed author sentiment.

Conclusions
The drive for pre-discharge interventions that reduce older adult hospital stays and associated costs continues to stem primarily from economic and governmental policies. Follow-up studies may be required to emphasize patient perspectives and care trajectories to avoid unintentional costly and health-deteriorating consequences.
Evaluation of a home-based parenting support programme—Parenting Young Children—For parents with intellectual and developmental disabilities when there is a risk for neglect: Study protocol for a multi-centre study
Authors: Holmefur Marie , Forslund Tommie , Randell Eva , Wennberg Birgitta , Ayoub Maria , Almqvist Lena , Fängström Karin , Janeslätt Gunnel , Strandberg Thomas 
Published: February 2025

Introduction
Parents with intellectual and developmental disabilities (IDDs) often need parenting support, but there are few evidence-based programmes adapted to their cognitive needs. Parenting Young Children (PYC), a home-based programme for parents with IDDs, is perceived as beneficial by parents and practitioners, but it is unclear if PYC improves parenting. The purpose of the proposed mixed-methods study is therefore to evaluate the PYC programme for improved parenting in parents with IDDs.

Methods and analysis
The quantitative evaluation will have a multi-centre, pretest-posttest study design and include parents with IDDs (children aged 0–9) in need of adapted parenting support. Goal-attainment in parenting skills, parental self-efficacy and child mental health will be measured outcomes. Interviews will be used to explore the perspectives of parents and children on PYC.

Ethics and dissemination
Particpation is based on informed consent from parents and guardians of the participating children. Ethical approval was granted by the Swedish Ethical Review Authority.
Explore the possible influence of Sjogren’s syndrome on thyroid cancer: A literature data mining and meta-analysis
Authors: Kong Fanyong , Han Boxuan , Wu Zhen , Chen Jiaming , Shen Xixi , Shi Qian , Hou Lizhen , Fang Jugao , Lian Meng 
Published: February 2025

Objectives
To explore the potential influence of Sjogren’s syndrome (SS) on thyroid cancer (TC).

Methods
First, a literature data mining (LDM) approach was used to reconstruct functional pathways connecting SS and TC. A meta-analysis was then performed to examine the expression changes of genes mediated by SS using 16 TC case/control expression datasets, with results validated through the TCGA/GTEx dataset. Finally, gene set enrichment analysis (GSEA) and survival analysis using GEPIA2 were conducted on the significant genes.

Results
Our findings indicate that SS may increase the risk of TC by activating 14 TC promoters (PDCD1, NTRK1, LGALS3, CD274, FOXP3, BCL2, CYP1A1, HMGB1, TGFB1, CCL2, PLA2G7, TFF3, LCN2, and CLDN1) and suppressing three TC inhibitors (MIR145, MIR30C1, and EP300). Four molecules (PLA2G7, TFF3, LCN2, and CLDN1) exhibited significant expression changes in TC patients (LFC > 1 or < -1; p < 2.07E-04), which were confirmed in TCGA/GTEx expression analysis. These results highlight three possible mechanisms—the SS-PLA2G7-CCL2-TC pathway, the SS-LCN2-LGALS3-TC pathway, and the SS-CLDN1-BCL2-TC pathway—that may explain how SS contributes to TC development. Enrichment analysis suggests that SS may affect TC prognosis by regulating leukocytes and tolerance induction. Survival analysis indicates that SS may enhance TC survival through the regulation of the CLDN1 and EGF pathways.

Conclusion
LDM-based pathway analysis highlighted three genetic pathways through which SS may adversely affect TC progression, while SS may enhance TC survival via the CLDN1 and EGF pathways, highlighting the need for further research.
Healthcare Contact Days Before and After Liver Transplant in Patients With Cirrhosis: A National Cohort Study
Authors: Elhence Hirsh , Brar Gurmehr , Dodge Jennifer L. , Lee Brian P. 
Published: February 2025

INTRODUCTION:
“Healthcare contact days” is a patient-centered quantitative proxy for time toxicity, which can be informative for liver transplant (LT) decision-making. We aimed to (i) quantify contact days in patients with cirrhosis pre-LT and post-LT and (ii) identify clinical and demographic features associated with contact days.

METHODS:
Using a national health system database, we calculated healthcare contact days (inpatient, outpatient hospital [e.g. observation], ambulatory, emergency, mental health, other) for patients with cirrhosis before and after LT.

RESULTS:
Between 2008 and 2023, 2,708 patients underwent LT (median age 59 years [interquartile range 52–65], 66% male, 68% non-Hispanic White). Total mean contact days were 76.0 (SD, 58.6) 1 year pre-LT, increasing to 92.3 (SD, 63.2) 1 year post-LT, then decreasing to 39.7 (SD, 43.3) and 30.9 (SD, 35.6) 2 years and 3 years post-LT, respectively. The mean inpatient contact days were 33.6 (SD, 47.5) 1 year pre-LT, increasing to 49.6 (SD, 59.1) 1 year post-LT, then decreasing to 11.9 (SD, 32.0) and 6.7 (SD, 19.8) 2 years and 3 years post-LT, respectively. In multivariable analysis, pre-LT contact days were not associated with post-LT days (incidence rate ratio [IRR] 1.00 [1.00–1.00]). Post-LT, female gender (IRR 1.09 [1.03–1.15]), Black race (IRR 1.11 [1.00–1.23]), and pre-LT dialysis (IRR 1.21 [1.10–1.34]) were associated with increased total contact days.

DISCUSSION:
Healthcare contact days provide interpretable prognostic information to inform expectations regarding LT for cirrhosis and can be useful for patients, providers, and policymakers alike.
The Inability to Form a Coalition: The Case of the Basic Income Proposal in Mexico
Authors: Zapata Celestino Kevin 
Published: February 2025

Abstract
The proposal for Basic Income (BI) pushed by renowned figures in Mexico sparked a vigorous debate over social policy between 2015 and 2018. This debate was particularly notable, as it challenged the long-standing dominance of conditional cash transfers, which had remained largely unquestioned as the country’s main antipoverty policy since their introduction in the 1990s. Despite the BI proposal getting wide coverage from the media, it not only failed to gain traction on the government’s agenda but also quickly became irrelevant right after the general elections of 2018. This was due to the unsuccessful coalition-building efforts of the BI proponents, who were unable to reconcile their political disagreements, overcome partisan competition, establish communication, and bridge their policy beliefs on various levels. By conducting interviews with relevant stakeholders, I conclude that the inability of the BI supporters to form a unified advocacy coalition made it impossible to promote social policy change.
One-sided extended g-Drazin inverses
Authors: Mosić Dijana 
Published: February 2025

Abstract
The principal goal of this paper is to present one-sided versions of the
extended g-Drazin inverse as weaker kinds of the extended g-Drazin inverse.
Precisely, we define left and right extended g-Drazin inverses for Banach algebra elements.
A number of characterizations for left and right extended g-Drazin inverses are developed.
Since we obtain equivalence between concepts of left (or right)
extended g-Drazin invertibility and left (or right) generalized Drazin invertibility, in fact, we get
new characterizations for left (or right) generalized Drazin invertibility as consequences.
As particular cases of one-sided extended g-Drazin inverses, we investigate
one-sided extended Drazin inverses.
Crystal structure of (E)-(3-(3,4-dimethylphenyl)acryloyl)ferrocene, C21H20FeO
Authors: Gao Yanrong , Xu Xiaona , Zhu Zhoujing , Tang Wenqiang 
Published: February 2025

Abstract
C21H20FeO, monoclinic, P21/c (no. 14), a = 27.666(3) Å, b = 5.9979(5) Å, c = 21.0340(19) Å, β = 112.226(3)°, V = 3231.0(5) Å3, Z = 8, R

gt
(F) = 0.1155 wR

ref
(F
2) = 0.3122, T = 170 K.
Generalized (ψ,φ)-contraction to investigate Volterra integral inclusions and fractal fractional PDEs in super-metric space with numerical experiments
Authors: Shah Syed Khayyam , Sarwar Muhammad , Hleili Manel , Samei Mohammad Esmael , Abdeljawad Thabet 
Published: February 2025

Abstract
This article demonstrates the behavior of generalized (

ψ
,
φ

\psi ,\varphi

)-type contraction mappings involving expressions of rational-type in the context of super-metric spaces. In this direction, we obtained unique and common fixed point results for a pair of mappings. The obtained results are then utilized to establish some corollaries. Moreover, numerical examples and applications related to the system of integral inclusions and fractal fractional partial differential equations have been presented to validate the established results. The central objective of this research is to provide a more comprehensive framework for generalizing classical results in the context of super-metric space.
Synthesis of carboxymethyl cellulose-β∼cyclodextrin-coated sulfaguanidine and its enhanced antimicrobial efficacy for paper protection
Authors: Li Yuxuan , Li Hua , Chen Xiaoshuang 
Published: February 2025

Abstract
To enhance the strength and antimicrobial properties of paper cultural relics, and prolong the life of paper cultural relics, it is an urgent need to prepare new material for preservation and protection of paper. In this paper, CMC-β-CD-SG was synthesized with β-CD as carrier and sulfaguanidine as inclusion complex, the suitable conditions for the synthesis of CMC-β-CD-sulfaguanidine was obtained. By testing the effects of different mass concentrations of sulfaguanidine solution on the tensile strength, tearing degree, folding times, whiteness, gloss and antimicrobial properties of the paper, the suitable conditions for coating paper were found. The results show that when inclusion mass concentration of 3 mg/mL is coated on the paper, its mechanical properties are improved, the gloss is slightly increased, and the whiteness is basically unchanged. At the same time, the paper has certain antimicrobial properties, which is in line with the principle of “repairing the old as old”. CMC-β∼CD-SG studied in this paper exhibits properties of reinforcing, slow-releasing and antimicrobial activity for paper protection, which is an innovation of paper protection material, provides the theoretical basis and data reference, as well as a new research idea and technical approach for the development of products for paper protection.
Determination and pharmacokinetics of violanthin in mouse plasma by UPLC-MS/MS
Authors: Zhan Haichao , Dong Xicheng , Fan Yishun , Wang Yucan , Xu Jinmiao , Ma Jianshe , Wang Xianqin , Yu Xiaomin 
Published: February 2025

AbstractViolanthin, a compound isolated from the stems of Dendrobium officinale, exhibits potent antioxidant and antibacterial activities. However, no research has been conducted on the identification of violanthin in mouse plasma using UPLC-MS/MS. The present study aims to develop a selective UPLC-MS/MS method for the quantification of violanthin in mouse plasma. Samples were prepared using acetonitrile for protein precipitation, with aconitine as an internal standard (IS). Chromatographic separation was achieved on a UPLC HSS T3 column with acetonitrile and 0.1% formic acid as the mobile phase. Quantification was performed in multiple reactions monitoring (MRM) mode, targeting fragment ions m/z 579.6→457.2 for violanthin and m/z 646.6→586.5 for IS. Mouse blood samples were collected at different time points following intravenous (4 mg kg−1) and oral (30 mg kg−1) administration of violanthin. The calibration plots for violanthin in mouse plasma exhibited a linear trend across the entire range of 5–2,000 ng mL−1, with both intra-day and inter-day precision RSDs below 10%. The bioavailability was determined to be 24.3%. This UPLC-MS/MS method effectively facilitated pharmacokinetic studies of violanthin in mice.
Linguagem verbal no transtorno do espectro autista: estudo de casos
Authors: Rossi Camila , Parente Julia , Bosa Cleonice Alves , Salles Jerusa Fumagalli de 
Published: February 2025

Uma das características centrais na identificação dos casos de TEA é a comunicação peculiar das pessoas diagnosticadas. Os indicadores de linguagem não verbais para o diagnóstico de TEA em crianças tem sido bem documentado nas pesquisas de observação em contextos de interação social. Contudo, há necessidade de se investigar também os aspectos verbais por meio destas metodologias. O objetivo principal deste estudo é identificar as habilidades e os comprometimentos sociopragmáticos na linguagem verbal de uma criança com TEA, em comparação com uma criança sem TEA, no contexto de interação com a mãe. Pretende-se identificar os comportamentos repetitivos e estereotipados na linguagem verbal e no comportamento da criança, além de dificuldades na habilidade de conversação. Como objetivo secundário pretendeu-se avaliar a adequação de um protocolo de observação construído para avaliar os aspectos sociopragmáticos na linguagem verbal de crianças com TEA. Trata-se de um estudo de casos comparativos, de cunho descritivo e exploratório. Participaram deste estudo 2 crianças (uma com diagnóstico de TEA e outra sem TEA), com 5 anos de idade, e suas mães. Os resultados das sessões de observação demonstraram que foi possível identificar comprometimentos sociopragmáticos especificamente na criança com diagnóstico de TEA. O que mais diferenciou os dois casos foi a forma como a criança com TEA interagiu (dificuldades na prosódia e na atenção compartilhada, ausência de relato e presença de expressões estereotipadas e ecolalias) e pela dificuldade de coordenar o olhar com a fala. O protocolo parece ter cumprido seu objetivo, mas ainda necessita de revisão.
Práticas de leitura orientadas pela BNCC e sua relação com as metafunções da Gramática do Design Visual
Authors: Cordeiro Jessé , Santos Eudes 
Published: February 2025

A prática de leitura é intrínseca à comunicação humana, configurando uma das principais ferramentas para o desenvolvimento cognitivo, afetivo, cultural e social dos sujeitos. Tomando como base essa premissa, este trabalho tem como objetivo geral analisar a relação das práticas de leitura orientadas pela BNCC (2017) com as metafunções da Gramática do Design Visual - GDV. Para tanto, a pesquisa está ancorada nas discussões de Kress e Van Leeuwen (1996); Silva (2021); Souza (2021); Lima (2018) e Fernandes (2021). Os dados analisados demonstram que as metafunções representacional, interacional e composicional podem ser usadas para trabalhar as seguintes habilidades de leitura, entre outras, presentes na BNCC (2017): identificar o efeito de sentido produzido pelo uso de recursos expressivos gráfico-visuais, inferir e justificar o efeito de humor, ironia e/ou crítica e identificar e analisar efeitos de sentido decorrentes de escolhas e formatação de imagens nos textos multissemióticos presentes em abundância na geração multimidiática, o que pode ser observado na análise que foi realizada dessas habilidades a partir dos recursos multissemióticos presentes em narrativas de uma coleção de livro didático de língua portuguesa. O uso das metafunções pode fortalecer, caso sejam trabalhadas pelo professor de maneira eficiente, a potencialização das habilidades de leitura e compreensão de textos por alunos da escolarização básica. Enfim, as análises mostram que as metafunções da GDV são ferramentas capazes de ampliar as significações da leitura de textos multimodais/multissemióticos.
Synthesis of Ag-ZnO/MOF nanocomposite for degradation of dye from aqueous solution under UV light
Authors: Hameed Hayder Mahmood , Hasan Israa Abbas , Awad Afrah Turki 
Published: February 2025

Water pollution, a critical environmental challenge, threatens the availability of clean water essential for human survival. Industrial waste streams frequently discharge hazardous dyes such as Congo Red, Methyl Orange, and Methylene Blue, posing severe risks to aquatic ecosystems and human health. These dyes, widely used in industries like plastics, textiles, and cosmetics, contribute significantly to water contamination, necessitating effective treatment methods. This study addresses the research gap by synthesizing a silver-zinc oxide metal-organic framework (Ag-ZnO-MOF) nanocomposite for photocatalytic degradation of Methyl Orange dye using a chemical precipitation method. The nanocomposite's morphology, crystalline structure, and photocatalytic properties were characterized through SEM, FTIR, XRD, and DRS analyses, confirming its powdery nature and activity in the UV region with a bandgap of 3.3 eV. Key parameters influencing dye degradation, including solution pH, reaction time, pollutant concentration, and photocatalyst dosage, were systematically studied. The results revealed that optimal conditions (pH 2, 0.03 g photocatalyst, 30 ppm dye) achieved a remarkable 96% degradation efficiency. This research highlights the Ag-ZnO-MOF nanocomposite's potential for addressing industrial dye pollution, offering an effective and sustainable solution for water purification.
Keywords: Dye removal; metal-organic framework; methyl orange; photocatalyst.
Impact of charcoal and tree species on forest soil recovery after fire disturbance
Authors: Tran Thi Hong Van , Woś Bartłomiej , Wanic Tomasz , Pietrzykowski Marcin , Józefowska Agnieszka 
Published: February 2025

Abstract

Background and aims Charcoal and tree species are among the main factors influencing forest soil recovery after fire disturbance. This study investigates the impact of charcoal on the podzolization process and examines the effects of different tree species on soil properties in post-fire sites.Methods Research plots were established in pure stands of Scots pine (Pinus sylvestris L.), European larch (Larix decidua Mill.), silver birch (Betula pendula Roth), and pedunculate oak (Quercus robur L.) in two variants: with and without charcoal removal before tree planting. Soil samples were collected from various horizons and analyzed for various physical and chemical soil properties. The study utilized principal component analysis, correlation, and graphical representations prepared with Canoco 5 and R software to analyze the data.Results The presence of charcoal significantly accelerated the podzolization process, particularly under pine and birch stands. Tree species were found to distinctly affect soil formation, with pine and birch promoting more acidic conditions conducive to podzolization, while oak and larch had a more neutral effect. The comparison of soil classification systems revealed that the World Reference Base for Soil Resources more effectively captured the variations in soil properties influenced by tree species and charcoal compared to the USDA Soil Taxonomy.Conclusion Charcoal and tree species play crucial roles in post-fire soil recovery. The retention of charcoal can accelerate podzolization, especially under specific tree species, impacting soil classification and management strategies in fire-prone areas.