bluuebunny/crossref_metadata_2025_split huggingface dataset:
Welcome to fuckin' Letterkenny: Conceptualizing a modern Progymnasmata
Authors: Rachal Kimberly 
Published: March 2024

AbstractCrave TV's niche hit Letterkenny is packed with exercises in wordplay and examinations of semantics that serve various functions in its presentation of life in small‐town Canada. This article examines how the progymnasmata of classical rhetorical education and the linguistic comedy bits in Letterkenny serve a similar role in preparing their users (and viewers) to both engage in a specific type of dialogue and establish and enforce moral boundaries as are accepted in the society in which they live and participate, and how fan circulation of these language memes reflects the transference of those morals to the culture.
Peripheral and intestinal T lymphocyte subsets in dogs with chronic inflammatory enteropathy
Authors: Agulla Beatriz , Villaescusa Alejandra , Sainz Ángel , Díaz‐Regañón David , Rodríguez‐Franco Fernando , Calleja‐Bueno Lydia , Olmeda Patricia , García‐Sancho Mercedes 
Published: March 2024

AbstractBackgroundDysregulated T lymphocyte response is thought to play a key role in chronic intestinal inflammation (CIE).ObjectivesTo evaluate the presence of changes in peripheral and intestinal T lymphocyte subsets and to describe potential immune and inflammatory biomarkers in dogs with CIE.AnimalsSixteen healthy dogs and 26 dogs were diagnosed with CIE.MethodsProspective case‐control study evaluating peripheral and intestinal T lymphocytes using flow cytometry and inflammatory markers obtained from complete blood cell counts.ResultsDogs with CIE had higher peripheral activated T helper (Th) lymphocytes (87/μL [18‐273] CIE, 44/μL [16‐162] healthy control (HC, P = .013) and regulatory T cells (Treg; 108/μL [2‐257] CIE, 34/μL [1‐114] HC, P = .004). In the intestinal epithelium, CIE dogs presented lower percentages of Th (4.55% [1.75‐18.67] CIE, 8.77% [3.79‐25.03] HC, P = .002), activated Th cells (0.16% [0.02‐0.83] CIE, 0.33% [0.05‐0.57] HC, P = .03) and CD4/CD8 ratio (0.08 [0.02‐0.39] CIE, 0.21 [0.07‐0.85] HC, P = .003). Conversely, higher percentage of activated T cytotoxic cells (20.24% [3.12‐77.12] CIE, 12.32% [1.21‐39.22] HC, P = .04) and interferon‐gamma (IFN‐γ) producing T lymphocytes (7.36% [0.63‐55.83] CIE, 1.44% [0.00‐10.56] HC, P = .01) within the epithelium was observed. In the lamina propria the percentage of Treg lymphocytes was higher (6.02% [1.00‐21.48] CIE, 3.52% [0.18‐10.52] HC, P = .02).Conclusions and Clinical ImportanceSystemic and intestinal immune alterations occur in dogs with CIE suggesting that blood IFN‐γ producing T lymphocytes and the systemic immune‐inflamation index (SII) could potentially serve as biomarkers for the disease.
A simulation study comparing common methods for analyzing species–habitat associations of plants
Authors: Hesselbarth Maximilian H. K. , Wiegand Kerstin 
Published: March 2024

AbstractQuestionSpecies‐specific habitat associations are one of several processes that lead to a clustered spatial pattern of plant populations. This pattern occurs in tropical and temperate forests. To analyze species–habitat associations, four methods are commonly used when determining species–habitat associations from spatial point pattern and environmental raster data. Two of the methods randomize the spatial point pattern of plants, and two randomize the raster data of habitat patches. However, the strengths and weaknesses of the four methods have never been analyzed in detail.MethodsWe conducted a simulation study to analyze the strengths and weaknesses of the four most used methods. The methods are the gamma test, pattern reconstruction, the torus‐translation test and the randomized‐habitats procedure. We simulated neutral landscapes representing habitat patches and point patterns representing fine‐scale plant distributions. We built into our simulations known positive and negative species–habitat associations.ResultsAll four methods were equally good at detecting species–habitat associations. Detected positive associations better than negative ones. Furthermore, correct detections were mostly influenced by the initial spatial distribution of the point patterns, landscape fragmentation and the number of simulated null model randomizations.ConclusionsThe four methods have advantages and disadvantages, and which is the most suitable method largely depends on the characteristics of the available data. However, our simulation study shows that the results are consistent between methods.
Effectiveness of HealthTracker for post‐caesarean section surgical site infection surveillance: An intervention study
Authors: Ohr Se Ok , Ball Jean , Teber Erdahl , Ferguson John K. , Petherbridge Rachael , Giles Michelle 
Published: March 2024

AbstractThis intervention study aimed to implement and evaluate the effectiveness of HealthTracker, a post‐discharge surgical site infection surveillance system. Participants were 730 women birthing by caesarean section at a large hospital over a 6‐month period. Data were downloaded from clinical data systems and HealthTracker. Receiver operating characteristics were used to assess HealthTracker. Over a 6‐month period, 382 women completed HealthTracker, with 83 scoring ≥6, indicating signs and symptoms of surgical site infection. Of this 83, 58 sought advice from health professionals, 29 returned to hospital, and 45 received antibiotics. A total of 20 infections from a total population of 730 were confirmed, with 14 out of 382 respondents confirmed via HealthTracker. Receiver operating characteristics identified HealthTracker as an excellent indicator of surgical site infection. HealthTracker is a feasible mHealth option for monitoring post‐discharge surgical site infection post‐caesarean section. In addition, by providing alerts, advising women to monitor their symptoms and seek treatment if necessary, HealthTracker has the potential to enhance self‐efficacy for surgical wound monitoring at home.
The emergence of cultural safety within kidney care for Indigenous Peoples in Australia
Authors: Arnold‐Ujvari Melissa , Rix Elizabeth , Kelly Janet 
Published: March 2024

AbstractCultural safety is increasingly recognised as imperative to delivering accessible and acceptable healthcare for First Nations Peoples within Australia and in similar colonised countries. A literature review undertaken to inform the inaugural Caring for Australians with Renal Insufficiency (CARI) guidelines for clinically and culturally safe kidney care for Aboriginal and Torres Strait Islander peoples revealed a timeline of the emergence of culturally safe kidney care in Australia. Thirty years ago, kidney care literature was purely biomedically focused, with culture, family and community viewed as potential barriers to patient ‘compliance' with treatment. The importance of culturally informed care was increasingly recognised in the mid‐1990s, with cultural safety within kidney care specifically cited from 2014 onwards. The emergence timeline is discussed in this paper in relation to the five principles of cultural safety developed by Māori nurse Irihapeti Ramsden in Aotearoa/New Zealand. These principles are critical reflection, communication, minimising power differences, decolonisation and ensuring one does not demean or disempower. For the kidney care workforce, culturally safe care requires ongoing critical reflection, deep active listening skills, decolonising approaches and the eradication of institutional racism. Cultural safety is the key to truly working in partnership, increasing Indigenous Governance, respectful collaboration and redesigning kidney care.
Monocots and eudicots have more conservative flower water use strategies than basal angiosperms
Authors: Ke Y. , Zhang Y.‐B. , Zhang F.‐P. , Yang D. , Wang Q. , Peng X.‐R. , Huang X.‐Y. , Sher J. , Zhang J.‐L. 
Published: March 2024

ABSTRACT

Water balance is crucial for the growth and flowering of plants. However, the mechanisms by which flowers maintain water balance are poorly understood across different angiosperm branches.

Here, we investigated 29 floral hydraulic and economic traits in 24 species from ANA grade, magnoliids, monocots, and eudicots. Our main objective was to compare differences in flower water use strategies between basal angiosperms (ANA grade and magnoliids) and derived group (monocots and eudicots).

We found that basal angiosperms had richer petal stomatal density, higher pedicel hydraulic diameter, and flower mass per area, but lower pedicel vessel wall reinforcement and epidermal cell thickness compared to monocots and eudicots. We also observed significant trade‐offs and coordination among different floral traits. Floral traits associated with reproduction, such as floral longevity and size, were strongly linked with physiological and anatomical traits.

Our results systematically reveal the variation in flower economic and hydraulic traits from different angiosperm branches, deepening understanding of flower water use strategies among these plant taxa. We conclude that basal angiosperms maintain water balance with high water supply, whereas monocots and eudicots maintain a more conservative water balance.
Homonormativity in Peripheral Spaces: LBT Women's Processes of Becoming Political Subjects
Authors: Hartal Gilly , Krauz Shany 
Published: March 2024

AbstractHomonormativity refers to the ratification and endorsement of heteronormative institutions and structures into lesbian, gay, bisexual and transgender (LGBT) lives, culture and discourse. While homonormativity is commonly manifested in (relatively) privileged, White, able‐bodied gay men, this paper focuses on lesbian, bisexual and transgender (LBT) women's experiences in Israeli peripheral and rural spaces. As a concept, homonormativity has the potential of reducing lived experiences into a widely criticized category. Instead, we voice the geographical, temporal and gendered potential of homonormative processes to articulate varied ways for leading a queer life under capitalism. Based on 61 qualitative interviews with LBT women living in the Israeli peripheries, we argue that LBT women employ two major homonormative processes of becoming political subjects to negotiate their sexualities in a space fraught with LGBTphobia. These homonormative processes are comprised of assimilation and contestation, revealing a nuanced mode of political subjectivity, shaped by ongoing experiences of LGBTphobia.
Outcomes of dogs with apocrine gland anal sac adenocarcinoma treated via modified closed anal sacculectomy (2015–2022)
Authors: Davey Emma L. , Prpich Cassandra Y. 
Published: March 2024

AbstractObjectiveTo evaluate the postoperative complication rate and local recurrence rate of apocrine gland anal sac adenocarcinoma (AGASACA) in dogs surgically treated with a modified closed anal sacculectomy technique between 2015 and 2022.Study designObservational clinical retrospective study.Animal populationForty‐seven client‐owned dogs histologically diagnosed with AGASACA.MethodsMedical records were evaluated for patient demographics and history, physical examination findings, diagnostic imaging, incidence of concurrent neoplasia, postoperative complications, and incidence and time to local recurrence. Dogs with at least 150 days of follow‐up were included in evaluation of local recurrence.ResultsTwo dogs were euthanized at 4 and 11 days after surgery. Forty‐five dogs were included for long‐term local recurrence evaluation, with a median of 364 days of follow‐up (range 156–2156 days). Only one dog (2.2%) developed local recurrence with a time to recurrence of 90 days. Postoperative complications were reported in 15 dogs (31.9%) and were considered minor in 14 dogs (93.3%) and major in one dog (6.7%). Mean survival time for the 20 dogs that were deceased as of November 1, 2022 was 521 days (range 156–1409 days) and the median survival time was 388 days.ConclusionThe modified closed anal sacculectomy technique resulted in a lower AGASACA local recurrence rate than previously reported in the veterinary literature with a comparable postoperative complication rate.Clinical significanceGiven the low recurrence rate found in this study, the modified closed anal sacculectomy technique may reduce the need for adjuvant radiation therapy and potentially chemotherapy in AGASACA patients.
Adaptive shifts in Phanaeini dung beetles of the Mexican plateau cenocron in the Mexican transition zone
Authors: Lizardo Viridiana , Escobar Federico , Martínez‐Meyer Enrique , Morrone Juan J. 
Published: March 2024

AbstractThe Mexican Transition Zone is a biogeographically complex area where old and new lineages of Neotropical and Nearctic affinities overlap. Its biota was assembled by successive dispersal events of cenocrons, which are sets of taxa that dispersed during a given time interval from both North and South America and then diversified in the area. The Mexican Plateau cenocron, with Neotropical affinities, is found in temperate and dry climates in the Nearctic region. We hypothesised that it underwent an adaptive shift in environmental niche. We tested this hypothesis using a phylogenetic comparative framework, measuring phylogenetic signal and fitting to single optima macroevolutionary models, and an Ornstein‐Uhlenbeck macroevolutionary model with multiple optima. We used phylogenetic and distributional information of the tribe Phanaeini to assess whether there exists a distinction in conservatism between the earliest (Mexican Plateau) and most recent (Typical Neotropical) cenocrons within the Mexican Transition Zone (MTZ) as this tribe stands as a classic example of the dispersal and diversification patterns of cenocrons originating in the Neotropics. We identified different shifts in environmental requirements that match the niche description of the Mexican Plateau cenocron, suggesting that it was established through multiple adaptive shifts in the Mexican Transition Zone.
Consequence of Red Blood Cells Deformability on Heat Sink Effect of Blood in a Three-Dimensional Bifurcated Vessel
Authors: Das Sidharth Sankar , Mahapatra Swarup Kumar 
Published: March 2024

Abstract
Several diseases like Sickle Cell Anemia, Thalassemia, Hereditary Spherocytosis, Malaria, and Micro-angiopathic Hemolytic Anemia can alter the normal shape of red blood cells (RBCs). The objective of this study is to gain insight into how a change in RBC deformability can affect blood heat transfer. The heat sink effect in a bifurcated vessel with two asymptotic cases (case 1: deformable and case 2: nondeformable RBCs) is being studied during hyperthermia treatment in a three-dimensional bifurcated vessel, whose wall is being subjected to constant heat flux boundary condition. Euler–Euler multiphase method along with the granular model and Kinetic theory is used to include the particle nature of RBCs during blood flow in the current model. To enhance the efficiency of the numerical model, user-defined functions (UDFs) are imported into the model from the C++ interface. The numerical model used is verified with the experimental results from (Carr and Tiruvaloor, 1989, “Enhancement of Heat Transfer in Red Cell Suspensions In Vitro Experiments,” ASME J. Biomech. Eng., 111(2), pp. 152–156; Yeleswarapu et al. 1998, “The Flow of Blood in Tubes: Theory and Experiment,” Mech. Res. Commun., 25(3), pp. 257–262). The results indicate that the deformability of RBCs can change both the flow dynamics and heat sink effect in a bifurcated vessel, which subsequently affects the efficacy and efficiency of the thermal ablation procedure. Both spatial and transient Nusselt numbers of blood flow with deformable RBCs are slightly higher compared to the one with nondeformable RBCs.
Estimation of Piston Surface Temperature During Engine Transient Operation for Emissions Reduction
Authors: Yang Zhijia , Mason Byron , Bae Brian Wooyeol , Bonatesta Fabrizio , Winward Edward , Burke Richard , Chappell Edward 
Published: March 2024

Abstract
Piston surface temperature is an important factor in the reduction of harmful emissions in modern gasoline direct injection (GDI) engines. In transient operation, the piston surface temperature can change rapidly, increasing the risk of fuel puddling. The prediction of the piston surface temperature can provide the means to significantly improve multiple-pulse fuel injection control strategies through the avoidance of fuel puddling. It could also be used to intelligently control the piston cooling jet (PCJ), which is common in modern engines. Considerable research has been undertaken to identify generalized engine heat transfer correlations and to predict piston and cylinder wall surface temperatures during operation. Most of these correlations require in-cylinder combustion pressure as an input, as well as the identification of numerous model parameters. These requirements render such an approach impractical. In this study, the authors have developed a thermodynamic model of piston surface temperature based on the global energy balance (GEB) methodology, which includes the effect of PCJ activation. The advantages are a simple structure and no requirement for in-cylinder pressure data, and only limited experimental tests are needed for model parameter identification. Moreover, the proposed model works well during engine transient operation, with maximum average error of 6.68% during rapid transients. A detailed identification procedure is given. This and the model performance have been demonstrated using experimental piston crown surface temperature data from a prototype 1-liter 3-cylinder turbocharged GDI engine, operated in both engine steady-state and transient conditions with an oil jet used for piston cooling turned both on and off.
PRPF19 mRNA Encodes a Small Open Reading Frame That Is Important for Viability of Human Cells
Authors: Shepelev N. M. , Kurochkina A. O. , Dontsova O. A. , Rubtsova M. P. 
Published: March 2024

Abstract
High-throughput ribosome profiling demonstrates the translation of thousands of small open reading frames located in the 5′ untranslated regions of messenger RNAs (upstream ORFs). Upstream ORF can both perform a regulatory function by influencing the translation of the downstream main ORF and encode a small functional protein or microprotein. In this work, we showed that the 5′ untranslated region of the PRPF19 mRNA encodes an upstream ORF that is translated in human cells. Inactivation of this upstream ORF reduces the viability of human cells.
Are children living with obesity more likely to experience musculoskeletal symptoms during childhood? A linked longitudinal cohort study using primary care records
Authors: Firman Nicola , Homer Kate , Harper Gill , Robson John , Dezateux Carol 
Published: March 2024

ObjectiveTo assess whether there is a higher incidence of musculoskeletal consultations in general practice among children with obesity.DesignLongitudinalSetting285 north-east London general practitioners (GPs).Participants63 418 (50.9% boys) Reception and 55 364 (50.8% boys) Year 6 National Child Measurement Programme (NCMP) participants, linked to GP electronic health records (EHRs).Main outcome measureA GP consultation with a recorded musculoskeletal symptom or diagnosis.MethodsWe calculated proportions with a musculoskeletal consultation by ethnic-adjusted weight status (underweight <2nd; overweight ≥91st; obese ≥98th centile), sex, ethnicity, and area-level deprivation. We estimated mutually-adjusted hazard ratios (HR) and 95% confidence intervals (95% CI) using Cox’s proportional regression models stratified by school year and sex.ResultsWe identified 1868 (3.0%) Reception and 4477 (8.1%) Year 6 NCMP participants with at least one musculoskeletal consultation. In adjusted analyses, Reception year girls with a body mass index (BMI) classified as overweight (HR 1.24, 95% CI 1.02 to 1.52) or obese (HR 1.67, 95% CI 1.35 to 2.06) were more likely to have at least one musculoskeletal consultation. Year 6 girls with obesity were more likely (HR 1.20, 95% CI 1.07 to 1.35), and boys with a BMI in the underweight range were less likely (HR 0.39, 95% CI 0.21 to 0.73), to have a musculoskeletal consultation.ConclusionsGirls living with obesity at the start or end of primary school are more likely to attend their GP for a musculoskeletal consultation. Routine linkage of NCMP data to EHRs provides useful insights into childhood health conditions related to excess weight in early childhood. Recognition of obesity as a contributing factor for musculoskeletal symptoms may inform clinical management, particularly in girls.
Impact of filgotinib on pain control in the phase 3 FINCH studies
Authors: Taylor Peter C , Kavanaugh Arthur , Nash Peter , Pope Janet , Pongratz Georg , Fautrel Bruno , Alten Rieke , Hasegawa Ken , Rao Shangbang , de Vries Dick , Stiers Pieter-Jan , Watson Chris , Westhovens Rene 
Published: March 2024

ObjectiveThis post hoc analysis of the FINCH 1–3 (NCT02889796,NCT02873936andNCT02886728) studies assessed specific effects of filgotinib on pain control and their relationship with other aspects of efficacy in patients with rheumatoid arthritis (RA).MethodsAssessments included: residual pain responses of ≤10 and ≤20 mm on a 100 mm visual analogue scale (VAS); the proportion of patients who achieved VAS pain responses in addition to remission or low disease activity by Disease Activity Score-28 with C-reactive protein (DAS28-CRP) or Clinical Disease Activity Index (CDAI) criteria.ResultsAcross studies, filgotinib reduced pain from week 2, with responses sustained throughout the studies. In FINCH 1, at week 24, 35.8%, 25.0%, 24.6% and 11.6% of patients in the filgotinib 200 mg, filgotinib 100 mg, adalimumab and placebo arms (each plus methotrexate) achieved VAS pain ≤20 mm in addition to DAS28-CRP remission; 26.3%, 17.9%, 17.2% and 7.6% achieved VAS pain ≤10 mm in addition to DAS28-CRP remission. A similar pattern was seen for CDAI remission. Time during which VAS pain was ≤10 or ≤20 mm was longest with filgotinib 200 mg and comparable between adalimumab and filgotinib 100 mg. Similar findings were reported for filgotinib in FINCH 2 and 3.ConclusionIn all RA populations studied, pain improvements occurred from week 2 and were sustained over time. In FINCH 1, filgotinib 100 mg provided similar pain amelioration to adalimumab, whereas filgotinib 200 mg resulted in greater pain improvement and higher proportion of patients with residual pain ≤10 or ≤20 mm and meeting DAS28-CRP remission criteria.
DFT computation of the electron spectra of thiophene
Authors: Chong Delano P. 
Published: March 2024

Recent experiments on thiophene using synchrotron radiation stimulated the present density functional theory (DFT) study of the various types of electron spectroscopy using the DFT methods we developed in our laboratory. Besides the confirmation of the experimental interpretations, the results of the present study strongly validate the methods used for the various types of electron spectroscopy. The average absolute deviations of the DFT results for thiophene from experiment are 0.22 eV for vertical ionization energies of outer valence electrons, 0.10 eV for carbon 1s binding energies, 0.19 eV for vertical valence excitation energies, and 0.18 eV for X-ray absorption energies. The calculated carbon 1s binding energies for bithiophene and terthiophene are also within 0.1 eV of synchrotron experiment. We conclude that workers using synchrotron radiation to study electronic processes of gas-phase molecules can apply our DFT methods for the interpretation of their experimental results.