bluuebunny/crossref_metadata_2025_split huggingface dataset:
Therapeutic significance of long noncoding RNAs in estrogen receptor‐positive breast cancer
Authors: Alzahrani Abdullah Ali , Saleh Raed Obaid , latypova Amaliya , Bokov Dmitry Olegovich , Kareem Anaheed Hussein , Talib Hayder Abdullah , Hameed Noora M. , Pramanik Atreyi , Alawadi Ahmed , Alsalamy Ali 
Published: March 2024

AbstractAbout 70% of cases of breast cancer are compromised by Estrogen‐positive breast cancer. Through its regulation of several processes, including cell proliferation, cell cycle progression, and apoptosis, Estrogen signaling plays a pivotal role in the genesis and progression of this particular kind of breast cancer. One of the best treatment strategies for treating Estrogen‐positive breast cancer is blocking Estrogen signaling. However, patients' treatment failure is mainly caused by the emergence of resistance and metastases, necessitating the development of novel therapeutic targets. Numerous studies have shown long noncoding RNAs (lncRNAs) to play a role in Estrogen‐mediated carcinogenesis. These lncRNAs interact with co‐regulators and the Estrogen signaling cascade components, primarily due to Estrogen activation. Vimentin and E‐cadherin are examples of epithelial‐to‐mesenchymal transition markers, and they regulate genes involved in cell cycle progression, such as Cyclins, to affect the growth, proliferation, and metastasis of Estrogen‐positive breast cancer. Furthermore, a few of these lncRNAs contribute to developing resistance to chemotherapy, making them more desirable targets for enhancing results. Thus, to shed light on the creation of fresh approaches for treating this cancer, this review attempts to compile recently conducted studies on the relationship between lncRNAs and the advancement of Estrogen‐positive breast cancer.
Overcoming Solubility Challenges: Liposomal isoCoQ‐Carbazole as a Promising Anti‐Tumor Agent for Inoperable and Radiation‐Insensitive cancers
Authors: Lamaa Diana , Cailleau Catherine , Vergnaud Juliette , Mougin Julie , Bignon Jérôme , Alami Mouad , Fattal Elias , Hamze Abdallah , Tsapis Nicolas 
Published: March 2024

AbstractThis study evaluated the potential of isoCoQ‐Carbazole, a diheterocyclic analog of isoCA‐4, as an anti‐tumor agent. To overcome its low aqueous solubility, liposomes were developed as a delivery system for the compound. In vitro experiments showed that loaded liposomes exhibited similar activity to the free form on multiple human tumor cell lines. In vivo experiments using a palliative intratumoral injection chemotherapy approach further demonstrated that isoCoQ‐Carbazole loaded liposomes significantly reduced tumor growth in a CA‐4‐resistant HT29 cell model, without inducing any observable toxicity or weight loss in the treated mice. These findings suggest that liposomal isoCoQ‐Carbazole may hold promise as a potential therapeutic agent for the treatment of inoperable, radiation‐insensitive cancers.
An optimized protocol for routine development of cell culture from adult oyster, Crassostrea madrasensis
Authors: Balakrishnan Soumya , Sajeevan Ambadi Kannan Maliyekkal , Parvathi Sreevidya Chandrasekharan , Bright Singh I. S. , Puthumana Jayesh 
Published: March 2024

AbstractMarine molluscan cell lines, required for virus screening and cultivation, form essential tools for developing health management strategies for these animals in the blue economy. Moreover, they are also crucial to develop cultivated seafood. As there is no valid marine molluscan cell line, primary cell cultures are relied upon for all investigations. A sound protocol for generating primary cell cultures from molluscs is entailed, but existing protocols often involve heavy antibiotic usage and depuration that invariably affect gene expression and cell health. This work presents an easy‐to‐adopt, time‐saving protocol using non‐depurated mollusc Crassostrea madrasensis, which requires only initial antibiotic treatment and minimal exposure or no use of antibiotics in the cell culture medium. The important experimental considerations for arriving at this protocol have been elucidated. Accordingly, sodium hypochlorite and neomycin sulfate were chosen for disinfecting tissues. The study is the first to use shrimp cell culture medium (SCCM) as a cell culture medium for molluscan cell culture. Despite being osmoconformers, the oysters exhibited stable intracellular osmotic conditions and pH, which, when provided in vitro, promoted effective cardiomyocyte formation. The cell viability could be enhanced using 10% fetal bovine serum (FBS), but healthy cell culture could also be obtained using SCCM without FBS. The optimized culture conditions allowed for regular beating cardiomyocyte clusters that could be retained for a month. Limited cell proliferation, as shown by the BrdU assay, demands further interventions, such as possibly producing induced pluripotent stem cells. The optimized protocol and culture conditions also align with some requirements for producing cultivated meat from marine molluscs.
An uncommon cause of sub‐acute intestinal obstruction in young adult: Wilkie's syndrome
Authors: Shrestha Kala , Thapa Niranjan , Basukala Sunil , Acharya Manisha , Bhulan Bibek Lama , Singh Kaushal Kumar , Shrestha Oshan , Chaudhary Kabita , Neupane Milan Kumar 
Published: March 2024

AbstractSuperior mesenteric artery (SMA) syndrome, also known as Wilkie's syndrome, is a rare disease presenting as an acute abdomen. It has a clinical presentation similar to intestinal obstruction and is often missed during diagnosis. Reduced weight leading to loss of fat pad between SMA and aorta is the main pathophysiology. Diagnosis is made through barium meal and CT scan. Conservative management remains the treatment of choice; however, surgery is opted for in refractory cases.Key Clinical MessageSuperior mesenteric artery (SMA) syndrome, also known as Wilkie's syndrome, is a rare disease presenting as an acute abdomen with clinical features similar to intestinal obstruction. This is a case of SMA syndrome in an adult male with a decrease in aortomesenteric angle, with no predisposing condition.
A chronic myeloid leukemia present with an unusual relapse in central nervous system: A case report
Authors: Musleh Mais , Alhussien Qossay 
Published: March 2024

Key Clinical MessageExtramedullary involvement of the central nervous system (CNS) in Chronic Myeloid Leukemia (CML) is an uncommon relapse. In this case, we present a unique instance of a 43‐year‐old male diagnosed with CML experiencing a CNS blast crisis.
CO2 Photoreduction over Semiconducting 2D Materials with Supported Single Atoms: Recent Progress and Challenges
Authors: Dai Zhangben , Yang Kejun , Yang Tianyi , Guo Yalin , Huang Jianfeng 
Published: March 2024

AbstractIn the face of the growing energy crisis and environmental challenges, substantial efforts are now directed toward sustainable clean energy as a replacement for traditional fossil fuels. CO2 photoreduction into value‐added chemicals and fuels is widely recognized as a promising approach to mitigate current energy and environmental concerns. Photocatalysts comprising single atoms (SAs) supported on two‐dimensional (2D) semiconducting materials (SAs‐2DSemi) have emerged as a novel frontier due to the combined merits of SA catalysts and 2D materials. In this study, we review advancements in metal SAs confined on 2DSemi substrates, categorized into four groups: (1) metal oxide‐based, (2) g‐C3N4‐based, (3) emerging, and (4) hybridized 2DSemi, for photocatalytic CO2 conversion over the past few years. With a particular focus on highlighting the distinct advantages of SAs‐2DSemi, we delve into the synthesis of state‐of‐the‐art catalysts, their catalytic performances, and mechanistic elucidation facilitated by experimental characterizations and theoretical calculations. Following this, we outline the challenges in this field and offer perspectives on harnessing the potential of SAs‐2DSemi as promising photocatalysts. This comprehensive review aims to provide valuable insights for the future development of 2D photocatalytic materials involving SAs for CO2 reduction.
Stabilization of the Neutral [25]Hexaphyrin(1.0.1.0.1.0) Radical by Hetero‐Bimetal‐Coordination
Authors: Xue Songlin , Dong Yuting , Lv Xiaojuan , Qiu Fengxian , Wang Yue , Furuta Hiroyuki , Teranishi Toshiharu , Wu Fan 
Published: March 2024

AbstractStabilization of hexaphyrin(1.0.1.0.1.0) (named “rosarin”) in its 25π radical state is achieved using a hetero‐bimetal‐coordination strategy. The antiaromatic BF2 complex B‐1 was first synthesized, and then rhodium ion was inserted into B‐1 to produce the BF2/Rh(CO)2 mixed complex Rh‐B‐1 as a highly air‐stable radical. The structures of B‐1 and Rh‐B‐1 were determined by single‐crystal X‐ray diffractions, and the antiaromatic or radical character was identified by various spectroscopy evidence and theoretical calculations. Rh‐B‐1 exhibits excellent redox properties, enabling amphoteric aromatic‐antiaromatic conversion to their 24/26π states. Compared to the 24/26π conjugation systems on the same skeleton, Rh‐B‐1 has the narrowest electrochemical and optical band gaps, with the longest absorption band at 1010 nm. The ring‐current analysis reveals intense paratropic currents for B‐1 and co‐existing diatropic‐paratropic currents for Rh‐B‐1. This hetero‐bimetal‐coordination system provides a novel platform for organic radical stabilization on porphyrinoids, showing the prospect of modulating ligand oxidation states through rational coordination design.
Evaluation of the effectiveness of mixing hydrochloric acid and organic acid as stimulation fluids in a tight gas carbonate reservoir
Authors: Khaleghi Mohammad Reza , Khamehchi Ehsan , Abbasi Amirhossein , Kalatehno Javad Mahdavi 
Published: March 2024

AbstractMatrix acidizing is a widely used technique in carbonate formations to improve production and injection rates by restoring or improving permeability. This study evaluates the stimulation efficacy of organic and inorganic acid combinations in the Sarajeh carbonate formation, with a focus on improving permeability within this potential tight gas formation. Through solubility and continuous flow tests, a mixture of HCl 7.5% + HAc 2.5% was found to significantly outperform the traditional HCl 15% solution. The HCl 7.5% + HAc 2.5% mixture had a solubility rate of 59.27% and improved permeability by 4.4 times compared to HCl 15%, indicating a higher dissolving capacity. The results of continuous flow tests showed that the mixed acid had the best pore volume to breakthrough (PVBt) value of 2.574 at a controlled injection rate of 2 cc/min. This study demonstrates the superior performance of a lower concentration HCl‐HAc acid formulation in matrix acidizing carbonate formations and confirms its potential as a more effective alternative to high concentration HCl treatments for the Sarajeh reservoir.
Improving model performance of shortest‐path‐based centrality measures in network models through scale space
Authors: Menguc Kenan , Yilmaz Alper 
Published: March 2024

SummaryThe quality of the solution in resolving a complex network depends on either the speed or accuracy of the results. While some health studies prioritize high performance, fast algorithms are favored in scenarios requiring rapid decision‐making. A comprehensive understanding of the problem necessitates a detailed analysis of the network and its individual components. Betweenness Centrality (BC) and Closeness Centrality (CC) are commonly employed measures in network studies. This study introduces a new strategy to compute BC and CC that assesses their sensitivity in the scale space while measuring the shortest path. The scale space is generated by incorporating a scale parameter that is shown to achieve up to 60% performance improvements for various datasets. The study provides in‐depth insights into the importance of the scale space analysis. Finally, a flexible measurement tool is provided that is suitable for various types of problems. To demonstrate the flexibility and applicability, we experimented with two methods for 10 different graphs using the proposed approach.
Spent Lithium‐Ion Batteries Derived Co3O4 for Electrocatalytic Polyethylene Terephthalate Plastic Recycling
Authors: Zhao Xinhui , Kuang Cheng , Liu Hongshu , An Chaopeng , Wang Mingyan , Mu Tiancheng 
Published: March 2024

AbstractSpent lithium‐ion batteries (LIBs) are an essential secondary resource containing valuable metal elements. Transforming spent LIBs into efficient catalysts through a simple process presents a promising strategy to address both metal resource scarcity and clean energy challenges. Herein, a deep eutectic solvent‐assisted synthesis of Co3O4 material from spent LIBs is proposed. The obtained Co3O4 material possesses efficient and stable electrocatalytic activity for converting raw polyethylene terephthalate (PET) bottles into high‐purity formic acid and terephthalic acid products under ambient conditions. As expected, the Co3O4 catalyst exhibits a high FE of 92 % with a concentration of produced potassium formate of 23.6 mM under alkaline conditions. This study presents a waste‐treating‐waste strategy for the simultaneous recovery of spent LIBs and PET waste in a greener manner.
Sex‐specific blood biomarkers linked to memory changes in middle‐aged adults: The Framingham Heart Study
Authors: Ding Huitong , Liu Chunyu , Li Yi , Ang Ting Fang Alvin , Devine Sherral , Liu Yulin , Au Rhoda , Doraiswamy P. Murali 
Published: March 2024

AbstractThe relationship between sex‐specific blood biomarkers and memory changes in middle‐aged adults remains unclear. We aimed to investigate this relationship using the data from the Framingham Heart Study (FHS). We conducted association analysis, partial correlation analysis, and causal dose–response curves using blood biomarkers and other data from 793 middle‐aged participants (≤ 60 years) from the FHS Offspring Cohort. The results revealed associations of adiponectin and fasting blood glucose with midlife memory change, along with a U‐shaped relationship of high‐density lipoprotein cholesterol with memory change. No significant associations were found for the other blood biomarkers (e.g., amyloid beta protein 42) with memory change. To our knowledge, this is the first sex‐specific network analysis of blood biomarkers related to midlife memory change in a prospective cohort study. Our findings highlight the importance of targeting cardiometabolic risks and the need to validate midlife‐specific biomarkers that can accelerate the development of primary preventive strategies.
Predicting 5‐year dementia conversion in veterans with mild cognitive impairment
Authors: Irwin Chase , Tjandra Donna , Hu Chengcheng , Aggarwal Vinod , Lienau Amanda , Giordani Bruno , Wiens Jenna , Migrino Raymond Q. 
Published: March 2024

AbstractINTRODUCTIONIdentifying mild cognitive impairment (MCI) patients at risk for dementia could facilitate early interventions. Using electronic health records (EHRs), we developed a model to predict MCI to all‐cause dementia (ACD) conversion at 5 years.METHODSCox proportional hazards model was used to identify predictors of ACD conversion from EHR data in veterans with MCI. Model performance (area under the receiver operating characteristic curve [AUC] and Brier score) was evaluated on a held‐out data subset.RESULTSOf 59,782 MCI patients, 15,420 (25.8%) converted to ACD. The model had good discriminative performance (AUC 0.73 [95% confidence interval (CI) 0.72–0.74]), and calibration (Brier score 0.18 [95% CI 0.17–0.18]). Age, stroke, cerebrovascular disease, myocardial infarction, hypertension, and diabetes were risk factors, while body mass index, alcohol abuse, and sleep apnea were protective factors.DISCUSSIONEHR‐based prediction model had good performance in identifying 5‐year MCI to ACD conversion and has potential to assist triaging of at‐risk patients.Highlights
Of 59,782 veterans with mild cognitive impairment (MCI), 15,420 (25.8%) converted to all‐cause dementia within 5 years.
Electronic health record prediction models demonstrated good performance (area under the receiver operating characteristic curve 0.73; Brier 0.18).
Age and vascular‐related morbidities were predictors of dementia conversion.
Synthetic data was comparable to real data in modeling MCI to dementia conversion.
Key Points
An electronic health record–based model using demographic and co‐morbidity data had good performance in identifying veterans who convert from mild cognitive impairment (MCI) to all‐cause dementia (ACD) within 5 years.
Increased age, stroke, cerebrovascular disease, myocardial infarction, hypertension, and diabetes were risk factors for 5‐year conversion from MCI to ACD.
High body mass index, alcohol abuse, and sleep apnea were protective factors for 5‐year conversion from MCI to ACD.
Models using synthetic data, analogs of real patient data that retain the distribution, density, and covariance between variables of real patient data but are not attributable to any specific patient, performed just as well as models using real patient data. This could have significant implications in facilitating widely distributed computing of health‐care data with minimized patient privacy concern that could accelerate scientific discoveries.
Probiotics: Bridging the interplay of a healthy gut and psychoneurological well‐being
Authors: Meher Ashish K. , Acharya Biswajeet , Sahu Prafulla K. 
Published: March 2024

AbstractThe establishment of a healthy microbiota, particularly during infancy, profoundly influences psychological health and neurological function through the gut‐brain axis. This review delves into the intricate connections between probiotics, gut microbiome development, and their impact on neurological disorders. Biotics, live microorganisms with proven health benefits, have emerged as a promising intervention, particularly during critical developmental stages. Administering specific probiotic strains (Lactobacillus species and Bifidobacterium) in infancy has shown promise in preventing and alleviating gut disorders, with implications for psychological well‐being. The bidirectional communication along the gut‐brain axis underscores the potential of probiotics in influencing neurological outcomes, ranging from anxiety to neurodevelopmental disorders. Additionally, this review explores emerging food engineering techniques (microencapsulation, genome editing, fermentation, protein engineering, immobilization, etc.) employed in preparing probiotic‐based foods, ensuring the viability and targeted release of probiotics in the gastrointestinal tract.
Laryngeal paraganglioma: The analysis of misdiagnosed cases and literature review
Authors: Dong Yi‐Jun , Zhang Hong‐Hui , Liang Jia‐Qiao , Gao Ya‐Ya , Xiong Ming , Yang Hui 
Published: March 2024

AbstractLaryngeal paraganglioma (LP) is an exceptionally rare neuroendocrine tumor, underscoring importance of accurate identification to preclude misdiagnoses. In this review, we presented two typical misdiagnosed LPs, and offered reviews of LP cases reported over the preceding decade and all documented misdiagnosed LP cases. Furthermore, we systematically investigated the underlying causes of misdiagnosis and elucidated key points for effective differentiation. A retrospective analysis of 28 LP cases revealed a predominant occurrence in middle‐aged women, with an average history of 25.1 months. Through an analysis of all misdiagnosed cases (n = 37), supraglottic LPs were frequently misidentified as laryngeal carcinomas and vascular tumors, while subglottic LPs were often misdiagnosed as thyroid cancers. And the occurrence of misdiagnosis resulted in delayed and inappropriate treatments, contributing to the deterioration of LP patients (14 cases, 37.8%). In conclusion, this review endeavored to heighten awareness of LPs, with the ultimate goal of advancing diagnostic precision and enhancing patient outcomes.
Self‐reported sexually transmitted infections among men and women in Papua New Guinea: A cross‐sectional study
Authors: Tetteh Justice Kanor , Aboagye Richard Gyan , Adu‐Gyamfi Addae Boateng , Appiah Seth Christopher Yaw , Seidu Abdul‐Aziz , Attila Frank Lamadoku , Ahinkorah Bright Opoku 
Published: March 2024

AbstractBackground and AimsSexually transmitted infections (STIs) pose a considerable concern for global healthcare systems. We examined the prevalence and correlates of self‐reported STIs (SR‐STIs) among men and women in Papua New Guinea.MethodsA total of 7,195 women and 4,069 men from Papua New Guinea who participated in the 2016–2018 Demographic and Health Survey were included in this study. Percentages were used to summarize the prevalence of SR‐STIs among men and women. A multivariable multilevel binary logistic regression was used to examine the correlates of SR‐STIs in men and women.ResultsAn overall 5.9% and 4.6% prevalence of SR‐STIs were recorded among women and men, respectively, in Papua New Guinea. The odds of SR‐STIs were higher among women who ever tested for HIV (aOR = 2.47, CI: 1.80–3.39), those who had first sex below 20 years (aOR = 1.76, CI: 1.10–2.80), those who watched television less than once a week (aOR = 1.83, CI: 1.13–2.95) and those from the Highlands and Momase regions (aOR = 5.55, CI: 3.30–9.33) compared to their counterparts who never tested for HIV, who had their first sexual intercourse when they were 20 years and above, who did not watch television at all, and those from the Southern Region. For men, the odds of SR‐STIs were high among those who ever tested for HIV (aOR = 1.65, CI: 1.11–2.45), those with one (aOR= 2.08, CI: 1.05–4.14) and two or more (aOR = 3.77, CI: 1.49, 9.52) sexual partners excluding spouse in the 12 months preceding the survey, those living in the Highlands region (aOR = 2.52, CI: 1.48–4.29), and those living in communities with medium literacy level (aOR = 2.33, CI: 1.38–3.94) compared to their counterparts who had never tested for HIV, those with zero sexual partners excluding their spouse in the 12 months preceding the survey, those living in the Southern region, and those living in communities with low literacy levels.ConclusionWe recommend that the National AIDS Council of Papua New Guinea through the National HIV and STI 2018–2022 Strategy program should be realigned to address these correlates and ensure that more sexual and reproductive health resources are provided to men and women in the Highlands and Momase regions.