bluuebunny/crossref_metadata_2025_split huggingface dataset:
A three‐dimensional thermal‐electrochemical‐mechanical‐porous flow multiscale formulation for battery cells
Authors: Kulathu Sandeep , Hurtado Juan A. , Bose Kingshuk , Hahn Youngwon , Bouzinov Pavel A. , Taylor Robert L. , Oancea Victor 
Published: March 2024

AbstractSeveral decades after the invention of the rechargeable Li‐ion battery, countless innovations from both the research and industry communities have led to placing the secondary battery at the heart of the electrification revolution in recent years. Mathematical and numerical models have been trusted companions in advancing the technology to help guide design improvements or to gain insight when physical measurements are impossible to perform. Starting with the breakthrough porous electrode theory (PET) model proposed by Newman and co‐workers in 1975 (Newman and Tiedemann, AIChE Journal, 1975, 21, 25–41), many authors have improved the formulation from a variety of perspectives. The novel aspects of the model we propose in this paper expand on this long stream of PET formulations and aim to address modeling needs that, to the authors' knowledge, have not been yet considered. The proposed formulation is characterized by the following concurrent features: (1) a full 3D description of the macroscale behavior and 1D microscale in spherical coordinates (Pseudo 4D formulation [P4D]) accounting for geometric details of the cell architecture such as imperfect spiral jellyrolls in cylindrical cells; (2) multiple concurrent particle chemistries to model the microscale lithiation/delithiation behavior at every macroscale element integration point, leading to a multiscale () approach; (3) a fully coupled thermal‐electrochemical‐mechanical stress interaction due to lithiation/delithiation induced swelling and external confinement; (4) spatially‐dependent porosity evolutions due to swelling of the particles in the porous electrodes; (5) electrolyte flow in the porous regions and overfill spaces via Darcy‐based flow including partial saturation of the active regions; (6) detailed descriptions of individual battery components such as the electrodes, separator, and current collectors with the possibility of “connecting” the different components through contact definitions; (7) fully linearized macro‐microscale coupling behavior allowing for large time increments in an implicit time integration scheme for a scalable and computationally effective numerical solution. A number of numerical examples including validation against experimental data are performed to demonstrate the predictive power of the proposed model and its efficiency for industrial applications.
Myocardial mechano‐energetic efficiency is not impaired in patients with metabolically healthy overweight and obesity
Authors: Cefalo Chiara Maria Assunta , Riccio Alessia , Fiorentino Teresa Vanessa , Succurro Elena , Mannino Gaia Chiara , Perticone Maria , Sciacqua Angela , Andreozzi Francesco , Sesti Giorgio 
Published: March 2024

AbstractObjectiveReduced myocardial mechano‐energetic efficiency (MEE) was associated with BMI. Subgroups of individuals with increased BMI but favorable cardiovascular risk profile were identified as individuals with “metabolically healthy overweight” (MHOW) and “metabolically healthy obesity” (MHO), respectively. We aim to investigate whether those with MHOW/MHO, defined as those having none of the components of metabolic syndrome, exhibit impaired MEE compared with their unhealthy counterparts.MethodsMyocardial MEE per gram of left ventricular mass (MEEi) was assessed by echocardiography in 2190 nondiabetic individuals participating in the CATAnzaro MEtabolic RIsk factors (CATAMERI) study who were divided, according to BMI and metabolic status, into groups of individuals with metabolically healthy normal weight (MHNW), metabolically unhealthy normal weight (MUNW), MHOW, metabolically unhealthy overweight (MUOW), MHO, and metabolically unhealthy obesity (MUO).ResultsAfter adjusting for age and sex, no differences in myocardial MEEi were observed among individuals with MHNW, MHOW, and MHO (p = 0.56). Myocardial MEEi was comparable among individuals with MUNW, MUOW, and MUO (p = 0.21). Individuals with MHNW, MHOW, and MHO displayed significantly higher myocardial MEEi compared with their unhealthy counterparts.ConclusionsIncreased BMI is not an obligate determinant for reduced myocardial MEEi. Other known components of metabolic syndrome rather than increased BMI contributed to reduced myocardial MEEi.
Development and Characterization of Plant‐derived Aristatoside C and Davisianoside B Saponin‐loaded Phytosomes with Suppressed Hemolytic Activity
Authors: Ercelen Sebnem , Bulkurcuoglu Bunyamin , Oksuz Mustafa , Nalbantsoy Ayse , Sarikahya Nazli Boke 
Published: March 2024

AbstractSaponins are glycosides widely distributed in the plant kingdom and have many pharmacological activities. However, their tendency to bind to cell membranes can cause cell rupture, limiting their clinical use. In the previous study, aristatoside C and davisianoside B were isolated from Cephalaria species. Cytotoxicity assays showed that they are more active on A‐549 cell lines than doxorubicin but caused hemolysis. In the current research, aristatoside C and davisianoside B were loaded to phytosomes called ALPs and DLPs respectively, and characterized for particle size, zeta potential, encapsulation efficiency, release kinetic, hemolytic activity, and cytotoxicity on A‐549 cell line. DLPs maintained the cytotoxic activity of the free saponins against A‐549 cells with IC50 of 9,64±0,02 μg/ml but dramatically reduced their hemolytic activity. Furthermore, temperature and time‐dependent stability studies based on the size and zeta potential of ALPs and DLPs revealed that the phytosomes have sustained release properties over 2 weeks. Overall, DLPs displayed cytotoxicity against A‐549 cells with minimal hemolysis and sustained release, highlighting their potential as nanotherapeutics for clinical applications.
Pediatric splenic infarction: Assessment of associated clinical conditions and outcome
Authors: Grishin Evgeny , Soudack Michalle , Levy‐Mendelovich Sarina , Bezalel Yael , Lubetsky Aharon , Cohen Omri , Brutman‐Barazani Tami , Efros Orly , Kenet Gili , Barg Assaf A. 
Published: March 2024

AbstractPediatric splenic infarction (SI) is rare yet clinically significant. Publications regarding this complication are mostly limited to case reports. This is a retrospective study examining SI etiology, clinical presentation, management, and outcomes among children. Twenty‐two patients (median age: 7.9 years) were included, mostly with pre‐existing hematological diseases. Splenomegaly (72%), thrombocytopenia, and anemia were common. Most of the patients did not receive antithrombotic therapy yet only two patients experienced recurrences. During follow up 36% of patients died, however no fatalities were attributed to thrombotic or bleeding complications.
Adequate menstrual suppression in adolescents with inherited bleeding disorders often requires multiple treatment changes: Retrospective cohort study of a multidisciplinary clinic
Authors: Brown Megan C. , Tickle Kelly , Woods Kalinda , Sidonio Robert F. 
Published: March 2024

AbstractHeavy menstrual bleeding (HMB) is often the presenting symptom for females with inherited bleeding disorders (IBD). Multidisciplinary clinics leverage the expertise of hematologists and women's health specialists. This study characterizes the complexity of HMB management for adolescents with IBDs from a large multidisciplinary clinic. Adolescents often required multiple different menstrual suppression treatments, with only about 20% achieving acceptable suppression with their first treatment. Adolescents switched therapy most often for uncontrolled bleeding, followed by adverse effects, and patient preference. Given the difficulty in achieving adequate menstrual suppression, multidisciplinary clinics offer necessary expertise in accomplishing bleeding control with minimal adverse effects.
Analytical quality by design based on knowledge organization: A case study of developing an ultrahigh‐performance liquid chromatography method for the detection of phenolic compounds
Authors: Tai Yanni , Zhao Mintong , Ding Feng , Wu Gelin , Qu Haibin , Gong Ping , Xie Yongjian , Zhou Peng , Gong Xingchu 
Published: March 2024

AbstractIntroductionDespite numerous successful cases, there are still some challenges in using analytical quality by design (AQbD) for the development of analytical methods. Knowledge organization helps to enhance the objectivity of risk assessment, reduce the number of preliminary exploratory experiments, identify potential critical method parameters (CMPs) and their scope.ObjectiveIn the present study, we aimed to develop a simple, rapid, and robust analytical method for detecting phenolic compounds in Xiaochaihu capsule intermediates utilizing knowledge organization.MethodsKnowledge organization and AQbD were combined to obtain the initial analytical conditions through knowledge collection, extraction, reorganization, and analysis. The quantitative relationship between critical method attributes (CMAs) and CMPs was then established by a definitive screening design. The method operable design region was calculated using an exhaustive Monte Carlo approach based on the probability of reaching the standard. Robustness investigation and methodological validation were finally performed.ResultsAnalytical target profiles, CMAs, potential CMPs, and initial analytical conditions were initially identified, and the optimized ranges of operating parameters were obtained. A UHPLC method was successfully established for the analysis of phenolic compounds in ginger–ginger pinellia percolate, and the method validation outcomes were also satisfactory.ConclusionThe developed method can be a reliable means to detect the phenolic compounds of Xiaochaihu capsule intermediates. Knowledge organization provides a new approach for making better use of prior knowledge, significantly enhancing the efficiency of analytical method development. The approach is versatile and can be similarly applied to the development of other methods.
Embedding social emotional learning from the bottom up in multi‐tiered services and supports frameworks
Authors: Guest Jessie D. , Ross Robbie A. , Childs Tasha M. , Ascetta Kate E. , Curcio Rachelle , Iachini Aidyn , Griffiths Lauren 
Published: March 2024

AbstractStudent mental health needs continue to rise across the United States and many students and families rely on schools to provide services to meet these needs. Yet, an overwhelming number of available frameworks and approaches to school mental health (SMH) and overlapping terminology surrounding SMH supports like trauma‐informed (TI) approaches, social and emotional learning (SEL), and others can lead to confusion and potentially less effective implementation of services and supports for students. In this paper, we aim to mitigate this confusion and offer a solution that integrates several of these approaches into a single complementary model with a special emphasis on the role of SEL. We first present an overview of commonly used SMH frameworks. Next, we present the Trauma‐Informed Multi‐Tiered Systems of Support Model (TI‐SEL MTSS)–an adaptation of the TITI‐SEL MTSS–to include and emphasize the specific role of SEL as a critical foundational layer within a multi‐tiered system of support. The proposed adapted model maintains the key structure of a MTSS while highlighting the importance of embedding SEL pedagogy in daily teaching practices and all aspects of school life. A case study is used to illustrate how the proposed model adaptations can be used in practice and in tandem with TI and SMH services without being conflated as the same service as SEL. Practical implications for implementation are discussed.
Stereotactic body radiation therapy for clinically diagnosed early‐stage non‐small cell lung cancer: Importance of accurate CT interpretation by experts
Authors: Nakamura Daisuke , Honda Koichi , Yamazaki Takuya , Hayashi Hideyuki , Tsutsui Shin , Fukushima Aya , Honda Sumihisa , Uetani Masataka , Ashizawa Kazuto 
Published: March 2024

AbstractIntroductionThis study evaluated the clinical outcomes of stereotactic body radiotherapy (SBRT) for both pathologically diagnosed (PD) and clinically diagnosed (CD) early‐stage non‐small cell lung cancer (NSCLC) and explored the significance of accurate expert computed tomography (CT) interpretation.MethodsWe retrospectively analyzed 95 patients with early‐stage NSCLC who received SBRT at our institution. Patients were classified into CD and PD groups. Two chest radiologists retrospectively interpreted the pre‐SBRT CT images to determine the tumor subtype and probability of malignancy (PM). Clinical findings, CT features, and treatment outcomes were compared between the two groups. The survival rate of the CD group was analyzed separately according to the PM grade.ResultsMedian overall survival for the CD and PD groups was 6.0 and 5.4 years (P = 0.57), respectively. Median cause‐specific survival was 10.2 years in the CD group and not reached in the PD group (P = 0.76). In the CD group, lung cancer mortality was lower in the low PM group (25% [1 of 4]) than in the high PM group (47.4% [9 of 19]).ConclusionIt may be desirable to evaluate the PM of the nodule using expert CT interpretation to decide whether SBRT is indicated in CD early‐stage NSCLC.
Relaxed static output stabilization of polynomial fuzzy control systems by Lagrange membership functions
Authors: Bao Zhiyong , Li Sike , Li Xiaomiao , Du Yuehao , Liu Fucai 
Published: March 2024

AbstractThis article is concerned with the stability analysis of the static output‐feedback polynomial fuzzy‐model‐based (SOF PFMB) control systems through designing a novel membership grade integration (MGI) approach. The nonconvex problems of the SOF PFMB control systems are convexificated into the convex conditions by introducing block diagonal positive‐definite Lyapunov matrix and nonsingular transformation matrix. We proposed new approximate membership functions, that is, Lagrange membership functions (LMFs), which can be introduced into the stabilization process to relieve the conservativeness of stability results. The LMFs are general representations of piecewise‐linear membership functions, which makes the number of stability conditions not limited by the number of sample points. In a fixed subdomain, arbitrary sample points can be employed by the LMFs method and achieve higher approximation capability by increasing more sample points so that membership grades can be incorporated into the system analysis. Furthermore, a novel MGI approach, including the information of premise variables and LMFs, is proposed making the stability conditions more relaxed. Finally, two simulation examples show the merits of the developed techniques.
The first unique‐headed bug (Hemiptera, Enicocephalomorpha) from Cretaceous Iberian amber, and the Gondwanan connections of its palaeoentomological fauna
Authors: Davranoglou Leonidas‐Romanos , Pérez‐de la Fuente Ricardo , Baňař Petr , Peñalver Enrique 
Published: March 2024

AbstractEnicocephalomorpha, also known as unique‐headed bugs, are a seldom‐collected infraorder of heteropteran insects whose evolutionary relationships have puzzled entomologists for more than a century. Unique‐headed bugs are exceptionally rare in the fossil record, which hinders our understanding of the morphological transformations of the lineage across time and also affects the calibration of molecular clock estimates used to date the origins of the infraorder. Here, we report the discovery of Enicocephalinus ibericus sp. nov. from Iberian amber in the Ariño deposit in Spain, early Albian (Early Cretaceous) in age. The new species represents the second oldest fossil enicocephalomorphan to date, and the second record of this infraorder from European deposits. Remarkably, the closest relative of E. ibericus is the congeneric E. acragrimaldii Azar from Lebanese amber that is c. 20 myr older (Barremian), indicating a long‐term persistence of the Enicocephalinus lineage across geological time. A review of the existing literature enabled us to record a total of 20 congeneric insect species that have been found in both Lebanese and Iberian ambers, suggesting the existence of previously underappreciated entomofaunal connections between southern Laurasia (the European archipelago) and northern Gondwana during the Cretaceous. We show that the palaeoentomological record holds remarkable potential for elucidating the faunistic exchanges and palaeobiogeographical patterns in the peri‐Tethyan region during the Cretaceous.
In silico investigation of the role of miRNAs in a possible developmental origin of prostate cancer in F1 and F2 offspring of mothers exposed to a phthalate mixture
Authors: Aquino A. M. , Fioretto M. N. , Alonso‐Costa L. G. , Rocha V. A. , Souza P. V. , Magosso N. , Barbisan L. F. , Justulin L. A. , Flaws J. A. , Scarano W. R. 
Published: March 2024

AbstractA previous study using miRNA sequencing revealed that exposure to a mixture of phthalates during pregnancy and lactation dysregulated rno‐miR‐184 and rno‐miR‐141‐3p in the ventral prostate (VP) of offspring. Here, rno‐miR‐184 and rno‐miR‐141‐3 expressions were obtained by RT‐qPCR in the VP of F1 males as well as in F2 offspring, aiming to establish a relationship with possible oncogenic targets through in silico analyses with multigenerational approach. Additionally, some targets were measured by western blots to highlight a possible relationship between the deregulated miRNAs and some of their targets. VP samples from rats exposed to a mixture of phthalates maternally during pregnancy and lactation (GD10 to PND21‐F1) and VP from offspring (F2) were examined. The phthalate mixture at both concentrations (20 μg and 200 mg/kg/day) increased the expression of both miRNAs in the F1 (PND22 and 120) and F2 (descendants of F1‐treated males) prostate. Target prediction analysis revealed that both microRNAs are responsible for modulating the expression and synthesis of 40 common targets. A phthalate target association analysis and the HPA database showed an interesting relationship among these possible miRNAs modulated targets with prostate adenocarcinoma and other oncogenic processes. Western blots showed alteration in P63, P53, WNT5, and STAT3 expression, which are targeted by the miRNAs, in the VP of F1/F2 males. The data draw attention to the epigenetic modulation in the prostate of descendants exposed to phthalates and adds to one of the few currently found in the literature to point to microRNAs signature as biomarkers of exposure to plasticizers.
Identifying immune‐related prognostic biomarkers in osteosarcoma: Development and validation of the tumor immune microenvironment risk model based on analysis of TCGA
Authors: Zhang Xiao , Fan Yizhe , Shen Zhongyuan , Chen Zhiyu , You Wulin 
Published: March 2024

AbstractObjectiveOsteosarcoma is a rare and aggressive malignancy with limited effective therapeutic options. This study aimed to identify immune‐related prognostic biomarkers and develop a prognostic model for osteosarcoma.MethodsWe performed integrated analysis of transcriptomic data and immune cell infiltration profiles of 84 osteosarcoma samples from the Cancer Genome Atlas (TCGA) database. Time‐dependent receiver operating characteristic (ROC) curve analysis was used to assess the prognostic value of the TIMErisk model. We also performed functional annotation and pathway enrichment analyses to explore the potential mechanisms underlying the TIMErisk model.ResultsWe identified a seven‐gene TIMErisk model (C2, APBB1IP, BST2, TRPV2, CCL5, GBP1, and F13A1) that was independently associated with overall survival of osteosarcoma patients. The TIMErisk model showed significant associations with immune cell infiltration and immunosuppressive gene expression. In addition, the TIMErisk model was associated with drug sensitivity, and we found that several immune checkpoint genes were significantly differentially expressed between high‐ and low‐TIMErisk groups. Functional annotation and pathway enrichment analyses revealed that the TIMErisk model was associated with multiple immune‐related pathways, including antigen processing and presentation, cytokine‐cytokine receptor interaction, and T cell receptor signaling pathway.ConclusionOur study identified a novel TIME‐based prognostic model for osteosarcoma that incorporates immune‐related genes and can be used to predict patient prognosis and response to immunotherapy. Our findings highlight the importance of the TIME microenvironment in osteosarcoma progression and suggest that immune‐related biomarkers may have clinical significance in the management of osteosarcoma.
Synthesis of mesoporous TiO2‐MCM‐41 photocatalyst for quinolone antibiotics removal from aqueous solution
Authors: Trang Nguyen Thi Thu , Xuan Mai Thi , Hoang Nguyen Viet , Dong Nguyen Thanh , Linh Pham Tuan , Nguyet Vu Thi , Nhiem Nguyen Thi , Vinh Tran Quang 
Published: March 2024

AbstractIn this paper, a significant aspect of using TiO2 photocatalyst immobilized on MCM‐41 mesoporous material by sol‐gel method for ciprofloxacin (CIP) and norfloxacin (NOR) antibiotics removals was studied. The structure and morphology of the materials were evaluated by X‐ray diffraction (XRD), energy‐dispersive X‐ray spectrometer analysis combined with field‐emission scanning electron microscopy (FESEM‐EDX), fourier transform infrared spectroscopy (FTIR), transmission electron microscopes (TEM), and N2 adsorption‐desorption isotherms (BET) methods. Characterization results indicated that the presence of TiO2 anatase phase with relatively high TiO2 content (up to 60 % by weight) did not destroy the mesopore system of MCM‐41 substrate. Photoactivity of the catalyst was tested through the degradation of two quinolone antibiotics, CIP, and NOR. In this study, the factors affecting the decomposition efficiency of the above pharmaceutical antibiotics such as, the immobilized content of TiO2 and the concentrations of antibiotics as and catalyst were also evaluated using Langmuir‐Hinshelwood (LH) model. The TiO2 immobilized on MCM‐41 material showed a better ability to remove CIP and NOR antibiotics than the commercial TiO2 nanoparticles (P25) due to the high dispersion of active sites on an MCM‐41 high specific surface area mesoporous substrate.
Synthesis of poly(Oak bark) particles from oak bark extract and its utilization as a drug carrier material
Authors: Alpaslan Duygu , Dudu Tuba Ersen , Aktas Nahit 
Published: March 2024

AbstractAs oak bark extract includes pharmaceutically meaningful precious biochemicals such as vanillic acid, quercetin, catechin, caffeic acid, gallic acid, ferulic acid, syringic acid, chlorogenic acid, q‐coumaric and protocatechuic acid, the present study focuses on synthesizing polymeric particles from that extract while keeping their targeted natural bioactivity. In this study, due to the bioavailability of oak bark extracts, poly(Oak bark)water extract (p(OB)w), poly(Oak bark)ethanol extract (p(OB)e) and poly(Oak bark)water‐ethanol extract (p(OB)we) particles were synthesized using redox polymerization method. Additionally, the biocompatibility, hydrogen peroxide scavenging (H2O2), antioxidant and antimicrobial activities of these substances were investigated. The characterization of the synthesized particles was conducted by FTIR and SEM methods. It was determined that even low amounts of particles (1 mg) had high antioxidant and H2O2 activity. It was found that the particles (0.1 mg/mL) showed antimicrobial activity against Staphylococcus aureus, Bacillus cereus, Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa, Candida albicans within the parameters tested for antimicrobial activity. Paracetamol, which is widely used as a model drug and especially recommended for use in the Covid‐19 outbreak, was chosen to test the release potential of the p(OB)w, p(OB)e and p(OB)w‐e particles. Paracetamol release studies were measured with a UV‐VIS spectrophotometer at pH 7.4 and 37°C.