bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGARUH RASIO UTANG, STRUKTUR MODAL, PROFITABILITAS TERHADAP NILAI PERUSAHAAN PADA PERUSAHAAN SEKTOR HEALTHCARE TAHUN 2018-2021
Authors: Puspitasari Gladys Beatrice Angelia , Hutabarat Francis , Sihotang Ronny Buha 
Published: March 2024

Sasaran dari penelitian ini adalah untuk menyelidiki bagaimana nilai perusahaan di sektor kesehatan akan berubah diantara tahun 2018 dan 2021 yang dipengaruhi rasio utang, struktur modal dan profitabilitas. Sampel sebanyak 68 terdiri dari 17 bisnis dan data penelitian selama 4 tahun. Time series dan cross section digabungkan dalam pendekatan data. Pendekatan analisis statistik deskriptif dan analisis regresi linier berganda yang memanfaatkan program PSPP, keduanya digunakan dalam penelitian ini. Berdasarkan temuan analisis, DAR berefek negatif dan signifikan terhadap PER, sedangkan DER berefek positif dan signifikan. Sementara PER memiliki efek secara negatif dan tidak signifikan oleh ROE.
Analisis Model Antrian Koperasi Kredit Swasti Sari Kupang
Authors: Rato Theresia Novita 
Published: March 2024

Tujuan penelitian ini adalah 1) mengetahui karakteristik sistem pelayanan pada Koperasi Kredit Swasti Sari Kupang, 2) menemukan model antrian yang dapat diterapkan pada sistem pelayanan di Koperasi Kredit Swasti Sari Kupang, dan 3) mengidentifikasi tingkat pelayanan pada Koperasi Kredit Swasti Sari Kupang.
Teknik Pengumpulan data yang digunakan adalah wawancara, observasi, studi pustaka, dokumentasi, dan kuesioner. Sampel penelitian berjumlah 100 responden. Teknik pengambilan sampel menggunakan teknik Purposive Convenience Sampling. Untuk menganalisis masalah pertama yaitu dengan melakukan pengamatan terhadap karakteristik sistem pelayanan yang terjadi di Koperasi Kredt Swasti Sari Kupang. Untuk menganalisis masalah kedua menggunakan model antrian, dari keempat model tersebut dipilih salah satu model yang paling cocok dengan teknis pelaksanaannya. Sedangkan untuk masalah ketiga yaitu dengan menghitung karakteristik operasi sistem pelayanan serta menghitung biaya fasilitas dan biaya antri yang kemudian dianalisis dengan menggunakan rumus tingkat pelayanan optimal.
Hasil, karakteristik sistem pelayanan di koperasi terdiri dari karakteristik kedatangan, karakteristik antrian, dan karakteristik fasilitas pelayanan. Hasil pengujian terhadap empat model antrian dengan teknis pelaksanaannya di lapangan diketahui bahwa model antrian yang paling sesuai adalah model antrian Single Channel – Multi Phase. Hasil pegujian tingkat pelayanan diketahui bahwa tingkat pelayanan Koperasi Kredit Swasti Sari Kupang belum optimal karena tingkat rata-rata pelayanan (μ) saat ini lebih kecil yaitu hanya 7,80 nasabah per jam, bila dibandingkan dengan kondisi idealnya sebesar 9,38 orang per jam, dengan nilai tingkat pelayanan optimal (μ optimal) yaitu sebesar 83,17% dari kapasitas pelayanan optimal.
Immunomodulatory Effect of Ethanol Extract of Pirdot Leaf (Saurauia vulcani Korth ) on CD4+ and IL-2 Hepatic Profile in Tyfoid Fever
Authors: Haslinda  , Rina Amelia  , Muhammad Ichwan  , Dwirita Anggraini  , Yunita Sari Pane  
Published: March 2024

Typhoid fever is an acute febrile disease caused by Salmonella typhi bacteria that is obtained orally either through food or from drinks.Many immunological activities that occur due to salmonella infection so that immunomodulators are needed to speed up the healing of one of them by using pirdot leaves. Pirdot leaves are widely distributed in Indonesia, especially in the Lake Toba area of North Sumatra.This plant has many bioactive components, one of which is flavonoids.The flavonoid component of pirdot Leaf has been widely studied and is believed to improve the immune system because it is able to increase the production of IL-2 which is involved in the activation and proliferation of lymphocyte cells and can increase T CD4 cells. T CD4+ it self is a signal transduction marker in the mechanism of typhoid fever that can activate Antigen Precenting Cell (APC) to provide resistance to foreign substances.
A Systematic review and meta analysis of estrogen receptor beta as a predictive factor in breast cancer patients
Authors: Armansyah Maulana Harahap  , Kurnia Agustini  , Sri Ningsih  
Published: March 2024

It is unclear how estrogen receptor beta (ER) affects prognosis in breast cancer that is in the early stages. To determine the predictive value of ER in patients with early-stage breast cancer, we conducted a systematic review and meta-analysis. We looked for studies that evaluated the ER status in breast cancer patients article between 2010 and 2018 by searching Medline, Embase, and the Web of Science. 1700 participants from 18 studies total who met our inclusion and exclusion criteria were included. A Technical Expert Panel (TEP) of 3 medical specialist and expertise of disorder the abnormally cell cycle and cancer performed the review using the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews) model. The TEP planned a research on PubMed selecting “cancer” and “Breast Cancer” as MeSH (Medical Subject Headings) term adding to PubMed Search Builder the terms “Estrogen” and “Estrogen receptor”. TEP is considered for eligibility articles published within the last 13 years, including original research, in particular in vitro studies, and animal and clinical studies in English. Results: Of the 90 identified studies, TEP included 15 studies, 8 Systematical Review, and 4 clinical studies and 3 Review report. Our scoping review describes and summarizes the important develop highlyselective anti-ERβ antibodies that are applied to large well characterized human breast cancer samples to validate their diagnostic potential and to explore ERβ-selective agonists in animal models of breast cancer to validate their therapeutic potential
Phytochemical Screening and Chemical Compounds of Moringa Oleifera Leaf Hot Water Extract
Authors: Siahaan Tanty Naomi , Basuki  , Amir Hamzah  
Published: March 2024

In this study, the phytochemical composition and chemical compounds present in Moringa oleifera leaf hot water extract were investigated. The extraction process involved using hot water to retain a wide range of bioactive constituents. Qualitative and quantitative analyses were employed to characterize the extract's phytochemical profile. Fourier Transform Infrared Spectroscopy (FT-IR) was employed to identify and quantify specific chemical compounds. The phytochemical analysis revealed the presence of various classes of secondary metabolites, including alkaloids, flavonoids, tannins, saponins, terpenoids and phenolics. These bioactive compounds have been associated with antioxidant, anti-inflammatory, and antimicrobial properties. Additionally, the FTIR analysis unveiled a spectrum of chemical constituents, including phenol compounds, flavonoids and alkaloids compounds, known for their potential health benefits.
Keywords: Bioactive, Chemical Compounds, Hot Water Extract, Moringa Oleifera, And Phytochemicals
Preparation of Kemuning (Murraya paniculata (L.) Jack) Leaf Extract Microencapsulation by Ionic Gelation Method As An Antibacterial
Authors: Gea Saharman , Hariyati  , Andriayani  , Pasaribu Khatarina Meldawati 
Published: March 2024

Extracts from the leaves of the kemuning plant have bioactive compounds that have potential as antibacterial. However, there are some difficulties when using bioactive compounds such as instability, reactivity and having a strong odor. To overcome this problem, it is important to carry out the treatment, namely, the microencapsulation technique. Microencapsulation is a technique for coating the active ingredient with a polymer that can protect the active component thereby increasing the bioavailability of the active compound to be covered by the coating material. The polymer materials used as coating materials in this study were chitosan and STTP using the ionic gelation method. The characteristics measured included the phytochemical test, PSA test, antibacterial, FTIR, and SEM. Phytochemical test results showed the presence of alkaloids, flavonoids, PSA test showed micro-sized encapsulation, antibacterial indicated the presence of a strong inhibitory zone which had potential as antibacterial, FTIR indicated the presence of OH, C=O, NH groups.
Keywords: Microencapsulation, Antibacterial, Kemuning Leaf Extract, Ionic Gelation.
ANALISIS PERANCANGAN BERBASIS UML PADA SISTEM WEB PROFIL VIDEO ANIMASI 2D DAN MAN’QOSIT SYARIAH
Authors: Fadli Muhamad 
Published: March 2024

Seiring dengan perkembangan teknologi saat ini, teknologi banyak digunakan sebagai sarana promosi dan informasi khususnya dalam bidang website yang saat ini menjadi media informasi yang membawa banyak kemudahan dalam penyajian tampilan informasi. Kecepatan dan kemudahan merupakan nilai positif dari internet Website dapat lebih mudah diakses oleh masyarakat dari berbagai daerah hanya dengan menggunakan internet Salah satunya dalam hal pemasaran produk. menjadi sarana promosi, pemasaran, dan penyampaian informasi yang efektif dan efisien kepada masyarakat. Website dapat mendukung terciptanya media informasi dan promosi yang efektif karena selama ini media promosi selalu dilakukan dengan menggunakan media cetak oleh sebab itu penulis menginginkan pembaharuan dalam periklanan. Video animasi dapat di promosikan melalui website guna menunjang khalayak ramai, dan banyak nya orang yg menggunakan website juga dapat mendukung banyaknya orang yang menjangkau video animasi tersebut. Website ini dirancangan dengan menggunakan, HTML, PHP dan MYSQL
Biosorption of Cu(II) Ions by Water Hyacinth Leaf Powder: Process Performance, Kinetics, and Biosorption Isotherm
Authors: Ratnawati Ratnawati , Prasetyaningrum Aji , Hargono Hargono , Zakaria Muhammad Fahmi 
Published: March 2024

The water hyacinth leaf powder (WH) was used to adsorb Cu(II) from wastewater. The WH was modified through sulfuric acid (A-WH) and sodium hydroxide (B-WH) treatments. The biosorption was studied with various initial pH, initial Cu(II) concentrations, and biosorp-tion time. The results show that the biosorption capacities of the biosorbents increase with the initial Cu(II) concentration. The optimum pH for the biosorption was 7.5, 7.0, and 7.5 for the WH, A-WH, and B-WH, respectively. The SEM images of the raw and treated WH revealed that alkali treatment could remove lignin more than the acid treatment, leaving more macropores in the B-WH than in the A-WH. The acid and alkali treatments to the WH leaf increase the biosorption capacity of the WH for Cu (II). The pseudo-second-order kinetic model can represent the dynamic behavior of the biosorption better than the pseudo-first-order model. The Langmuir model is better than the Freundlich model for describing the biosorption isotherm. The maximum biosorption capacities of the biosorbents predicted by the Langmuir model were 14.92 mg g−1, 18.32 mg g−1, and 23.27 mg g−1 for WH, A-WH, and B-WH, respectively.
Multidrug Resistance Pattern of Pseudomonas aeruginosa Isolated from Patients with Nosocomial Infection
Authors: Saha Poulomi , Chakrabarty Moumita , Kabir Rubaiya Binte , Ahsan Chowdhury Rafiqul , Yasmin Mahmuda 
Published: March 2024

Multidrug resistant (MDR) Pseudomonas aeruginosa is a threat to the patients having nosocomial infections as this pathogen increases the inpatients’ morbidity and mortality by slowing down the whole treatment process. The aim of this study was to evaluate multidrug resistant phenotypes among nosocomial strains of P. aeruginosa for analyzing their antibiotic susceptibility pattern. A total of 108 P. aeruginosa clinical isolates were recovered from various samples (pus, wound swab, urine, sputum, blood and tracheal aspirate) of patients with nosocomial infections. Antibiogram was performed by disc diffusion according to Kirby-Bauer method to study the antibiotic sensitivity pattern of the pathogen against 14 regularly used antibiotics (amikacin, aztreonam, ceftazidime, ceftriaxone, co-trimoxazole, ciprofloxacin, gentamicin, levofloxacin, meropenem, netilmicin, doxycycline, amoxicillin/clavulanic acid, piperacillin/tazobactam, and tigecycline) in Bangladesh. The overall frequency of drug resistance was found to be very high (53.7% - 98.1%) to all of the anti-pseudomonal drugs tested. Resistance of P. aeruginosa strains against piperacillin-tazobactam was significantly less (53.7%) as compared to other thirteen antibiotics. However, isolates showed highest resistance (98.1%) to aztreonam. Next in order of resistance were doxycycline (95.4%), ceftriaxone (94.4%), amoxiclav (93.5%), and the others. The present study suggests that regularly used medications can no longer be utilized as first line therapies for suspected pseudomonad infections. This study claims for urgent epidemiological monitoring of the MDR P. aeruginosa strains in all hospitals of Bangladesh to prevent rapid dissemination of this opportunistic pathogen.
Bangladesh J Microbiol, Volume 40, Number 1, June 2023, pp 7-13
Correlation between antibiotic resistance and biofilm formation in Klebsiella spp.
Authors: Barai Dipan , Rafe Mohibur Rahman , Nahar Najmun , Begum Shahin Ara , Akther Humaira , Begum Anowara 
Published: March 2024

Antibiotic resistance among various microbial species is becoming a global threat to human health. MDR, or multidrug resistance, is an organism’s ability to tolerate the effects of many antimicrobial treatments. Klebsiella spp. is the major bacteria that causes a variety of illnesses, including urinary tract infections. The primary goal of this study is to look into the relationship between antibiotic resistance and Klebsiella spp. biofilm production. This study included 26 clinical isolates of Klebsiella spp. (n=26) collected from a tertiary hospital in Bangladesh. Isolates were obtained from blood, wound swabs, urine, and other sources. Following isolation and identification, ampicillin resistance was found in all MDR Klebsiella spp. isolates, followed by Cefotaxime (84.61%), Polymyxin B (84.61%), Amoxicillin (80.76%), Trimethoprim (69.23%), Doripenem (57.69%), Ciprofloxacin (57.69%), Imipenem (50.0%), Meropenem (38.46%), and Oxytetracycline (34.61%). Out of 26 clinical isolates, about 26.92% (n=7) were positive for the bla-NDM-1 gene. However, 15.8% of Klebsiella spp. (n = 4) isolates tested positive for the blaOXA-1 gene. There were no bla-KPC gene positives. Plasmid profile analysis revealed that 24 of 26 Klebsiella spp. isolates included numerous plasmids ranging in size from less than 2kb to more than 10kb. Biofilm formation found that 31% of samples were extremely positive for biofilm formation, 69% were medium biofilm formation, and (n=4) isolates were positive for biofilm resistance gene out of a total of 26 isolates. This study provides an early report on the widespread presence of carbapenem-resistant Klebsiella spp., demonstrating the need for intensive surveillance systems and research initiatives in Bangladesh to reflect the influence of multidrug resistance features in clinical isolates and their risks.
Bangladesh J Microbiol, Volume 40, Number 1, June 2023, pp 25-32
Pemenuhan Hak Pendidikan Anak Jalanan di Kota Batam : Tantangan Dalam Mewujudkan Sustainable Development Goals (SDGs)
Authors: Tan Winsherly 
Published: March 2024

Sustainable Development Goals (SDGs) have the main goal of directing the development of education to the eighth goal. Normatively, Indonesia already has a set of regulations regulating the right to education for children. However, Indonesia is still faced with various problems regarding street children, including those faced by the Batam City government in fulfilling the right to education for street children. The purpose of this study is first, to analyze the effectiveness of fulfilling the right to education for street children in Batam City. Second, to analyze and deepen the constraints faced by Batam City in fulfilling the education rights of street children. In this research, Soerjono Soekanto's theory of legal effectiveness was used. The research method used in this research is juridical empirical. Based on the research results, it was found that the local government of Batam City has not been effective in fulfilling the right to education for street children with several obstacles such as low parental knowledge and low family economy of street children. Keywords: Keywords: Street Children; Right; Education
Pembentukan Peraturan Perundang-Undangan Yang Baik Dalam Revisi Undang-Undang Tentang Komisi Pemberantasan Korupsi
Authors: Putra Antoni 
Published: March 2024

Efforts to revise Law Number 30 of 2002 concerning the Commission of Corruption Eradication which became the basis for the formation of the Corruption Eradication Commission have been carried out repeatedly, and the peak occurred in 2019. In the revision carried out in 2019, there was a neglect of the principle of establishing good laws and regulations, causing rejection from the public during the discussion process in the House of Representatives, and this makes it difficult for the revised law to be accepted, causing a lot of judicial review at the Constitutional Court.Keywords: Corruption Eradication Commission; Law; Rejection; AbstrakUpaya revisi Undang-Undang Nomor 30 Tahun 2002 tentang Komisi Pemberantasan Tindak Pidana Korupsi yang menjadi dasar pembentukan Komisi Pemberantasan Korupsi telah dilakukan berulangkali, dan puncaknya terjadi pada 2019. Dalam revisi yang dilaukan pada 2019 tersebut, terjadi pengabaian terhadap prinsip pembentukan peraturan perundang-undangan yang baik sehingga menyebabkan terjadi penolakan dari publik saat proses pembahasan di Dewan Perwakilan Rakyat dan menyebabkan undang-undang hasil revisi juga sulit diterima sehingga menyebabkan banyak terjadi pengujian undang-undang di Mahkamah Konstitusi.Kata Kunci: Komisi Pemberantasan Korupsi, Undang-Undang, Penolakan;
Batasan Hak Mengemukakan Pendapat Di Muka Umum Dalam Sistem Demokrasi Dan Ketatanegaraan Indonesia
Authors: Effendi Orien 
Published: March 2024

Expressing opinions is a human right that every citizen has. The freedom to express opinions through thoughts orally, in writing, and so on, has been mentioned in the 1945 Constitution and the Universal Declaration of Human Rights. From historical perspective, the birth of freedom of opinion has at least played a very large role in initiating the idea of a democratic system that is currently being implemented by the Indonesia people. However, the existence of the right to freedom of opinion with the aim of being checks and balances in the system of government in Indonesia today often creates tension when its delivery in public, often leads to chaos and the like, which of course is out of the concept of procedures for expressing opinions as mandated by law. Keywords: Human Rights; Freedom; Opinion; UUD 1945. Mengemukakan pendapat merupakan hak asasi manusia yang dimiliki setiap warga negara. Kebebasan meyampaikan pendapat melalui pikiran dengan lisan, tulisan, dan lain sebagainya, telah disebutkan dalam Undang-Undang Dasar 1945 dan Deklarasi Universal Hak-Hak Asasi Manusia. Dalam pengamatan kacamata sejarah, lahirnya kebebasan berpendapat itu setidaknya telah berperan sangat besar mengawali gagasan sistem demokrasi yang kini diterapkan bangsa Indonesia. Namun keberadaan hak kebebasan berpendapat dengan tujuan sebagai checks and balances sistem pemerintahan di Indonesia dewasa ini seringkali menimbulkan ketegangan ketika penyampaiannya dimuka umum, tidak jarang berujung kericuhan dan sejenisnya, yang tentu saja hal tersebut sudah keluar dari konsep tata cara penyampaian pendapat sebagaimana amanat undang-undang.Kata Kunci: Hak Asasi Manusia; Kebebasan; Pendapat; UUD 1945.
Tindak Pidana Pencucian Uang pada Bandar Narkotika
Authors: Hoemijati Hoemijati 
Published: March 2024

Money laundering as a process or an act aims to hide or disguise the origin of money or property wealth, obtained from proceeds of crime which is then converted into assets that appear to originate from legitimate, deep activities its development is not only done by individuals but also corporations are used to commit money laundering. The purpose of this study is how to regulate money laundering by narcotics dealers. The writing method used to compile this paper is research normative law or library research, namely by collecting material from books, magazines, papers, internet, legislation and other scientific writings that are closely related to the aims and objectives of the preparation of this scientific work. This regulation concerning money laundering is regulated by Law Number 8 of 2010 concerning Prevention and Eradication of Money Laundering and other Laws closely related to money laundering such as narcotics, corruption, terrorism, Head of PPATK Decree, Bank Indonesia Regulation, Ministerial Decree Finance and other regulations.Keywords: Bandar; Criminal Acts, Money Laundering, Narcotics AbstrakTindak pidana pencucian uang sebagai suatu proses atau perbuatan yang bertujuan untuk menyembunyikan atau menyamarkan asal-usul uang atau harta kekayaan, yang diperoleh dari hasil tindak pidana yang kemudian diubah menjadi harta kekayaan yang seolah-olah berasal dari kegiatan yang sah, dalam perkembangannya, tidak hanya dilakukan oleh orang perseorangan saja tetapi korporasi juga digunakan untuk melakukan tindak pidana pencucian uang. Tujuan penelitian ini adalah bagaimana pengaturan tindak pidana pencucian uang yang dilakukan oleh bandar narkotika. Metode penulisan yang dipakai untuk menyusun tulisan ini adalah penelitian hukum normatif atau penelitian kepustakaan, yaitu dengan mengumpulkan bahanbahan dari buku, majalah, makalah, internet, peraturan perundang-undangan dan hasil tulisan ilmiah lainnya yang erat kaitannya dengan maksud dan tujuan dari penyusunan karya ilmiah ini. Pengaturan mengenai tindak pidana pencucian uang ini diatur oleh Undang-Undang Nomor 8 Tahun 2010 tentang Pencegahan dan Pemberantasan Tindak Pidana Pencucian Uang dan Undang-Undang lain yang berkaitan erat dengan pencucian uang seperti tindak pidana narkotika, korupsi, terorisme, Keputusan Kepala PPATK, Peraturan Bank Indonesia, Keputusan Menteri Keuangan, dan peraturan-peraturan lainnya.Kata Kunci: Bandar; Narkotika; Pencucian Uang; Tindak Pidana