bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ketidakkonsistenan Beberapa Huruf Konsonan Dalam Bahasa Inggris
Authors: Tambunsaribu Gunawan 
Published: March 2024

Banyak pembelajar pemula yang baru mengenal bahasa asing, sebagian besar bingung dalam mengucapkan kata-kata dalam bahasa asing tersebut dikarenakan perbedaan kosakata dan pengucapan kosakata bahasa asing tersebut berbeda dengan bahasa ibu atau bahasa nasional para pembelajar. Peneliti ini menggunakan merupakan penelitian pustaka (library research). Data penelitian ini diambil dari daftar kosakata yang salah diucapkan oleh mahasiswa pada saat sedang menjelaskan atau menyampaikan secara lisan tugas mata kuliah ‘Speaking’ di depan kelas. Penelitian ini mengungkapkan ketidak-konsistenan beberapa huruf hidup (consonant letter) dalam bahasa Inggris. Secara umum, perbedaan bunyi huruf konsonan dibagi menjadi dua, yaitu huruf konsonan bergema (voiced consonant sound) dan huruf konsonan tidak bergema (voiceless consonant sound). Dari data yang di dapatkan, penulis juga menemukan ketidakkonsistenan beberapa huruf konsonan termasuk gabungan dua huruf konsonan. Jenis huruf konsonan yang bunyinya tidak konsisten, yang ditemukan di dalam data penelitian ini, adalah huruf c, g, dan y, sedangkan gabungan dua huruf konsonan yang yang tidak konsisten bunyinya adalah huruf sh, ch, dan th. Penulis berharap agar hasil penelitian ini dapat berguna bagi siapapun yang ingin mempelajari tentang bunyi bahasa Inggris khususnya bunyi huruf-huruf yang memiliki bunyi yang tidak menetap (inconsistent) khususnya ketidak-konsistenan bunyi dari huruf-huruf konsonan bahasa Inggris.
Kata kunci: huruf konsonan, pelafalan bahasa Inggris, kosakata, ketidak-konsistenan bunyi
MULTILINGUALISM IN AN ESP ONLINE LEARNING CLASS A CASE IN AN ENGLISH FOR PROFESSIONAL COURSE
Authors: Wiannastiti Melania 
Published: March 2024

ESP (English for Specific Purposes) in online learning classes has its way of communicating since the students do not meet physically because they only meet virtually. The study aims to find out the languages used among the online learning students in an ESP online classroom, especially in interacting and communicating with one another in a team and virtual classroom, and to figure out the students’ attitude toward multilingualism in ESP online classroom communication. A questionnaire is distributed to 24 students joining an English for Professional class at BINUS Online Learning as the participants. The data from the questionnaire is analyzed qualitatively in the form of percentages. The result shows that the students apply multilingualism in the online learning class for interaction and communication. They show both positive and negative attitudes toward the use of many languages in their team and classroom communication while English is required as the means of communication and interaction in the team and classroom.
Keterlibatan Pelanggan dan Antesedennya pada Transaksi E-Commerce pada Generasi Z
Authors: Ridanasti Erlita 
Published: March 2024

ABSTRAK
Tujuan penelitian ini adalah untuk mengetahui pengaruh antara Customer Involvement terhadap Customer Participation pada transasksi e-commerce pada generasi Z; untuk mengetahui pengaruh antara Customer Involvement terhadap Customer Experience pada transasksi e-commerce pada generasi Z; untuk mengetahui pengaruh antara Customer Participation terhadap Customer Engagement pada transasksi e-commerce pada generasi Z; untuk mengetahui pengaruh antara Customer Experience terhadap Customer Engagement pada transasksi e-commerce pada generasi Z serta untuk mengetahui pengaruh antara Customer Involvement terhadap Customer Engagement pada transasksi e-commerce pada generasi Z. Penelitian inimenggunakan sampel orang yang pernah melakukan pembelian di e-commerce di Tokopedia/ Shopee dengan teknik pengambilan sampel berupa nonprobability sampling dan diperoleh sampel sebanyak 213 responden. Sedangkan teknik analisis data menggunakan SEM AMOS. Berdasarkan hasil analisis dan pembahasan dapat ditarik kesimpulan bahwa Customer Involvement berpengaruh positif terhadap Customer Participation, Customer Involvement berpengaruh positif terhadap Customer Experience, Customer Participation tidak berpengaruh terhadap Customer Engagement, Customer Experience berpengaruh positif terhadap Customer Engagement dan Customer Involvement berpengaruh positif terhadap Customer Engagement

Kata Kunci: Customer Involvement, Customer Participation, Customer Engagement dan Customer Experience
Analisis Faktor yang Mempengaruhi Enterprise Risk Management
Authors: Hamzah Amir , Febriansyah Yudi 
Published: March 2024

This research aims to produce empirical facts / models that can explain the factors that influence ERM. To test the hypothesis that has been formulated through proving the results of the research used in statistical calculations so that the results of proof showing the rejection of Ho or acceptance of Ha are obtained. In this research, the research object was Manufacturing Companies in the Consumer Goods Industry Sector in 2019. The results of the F test show that financial leverage, company complexity and company size jointly affect ERM. The results of the t test show that financial leverage has a significant negative effect on ERM, firm size has a significant positive effect on ERM, and industry competition has no significant effect on ERM.
keywords: financial leverage, industry competition, company size, ERM.
EVALUASI KINERJA AUDITOR DALAM KETEPATAN PEMBERIAN OPINI AUDIT PADA KANTOR AKUNTAN PUBLIK
Authors: Bangki Rafida 
Published: March 2024

The problem in this study is how the auditor's performance in the accuracy of giving an audit opinion at the Public Accounting Firm and how internal control over the auditor's performance is in the accuracy of giving an audit opinion. This research has purpose: (1) to know and identify implementation of auditor performance in the accuracy of the provision audit opinion (2) identify and analyze the internal control on auditor performance in the accuracy of the provision audit opinion. This research used primary data through interviews of five informant that worked in Public Accounting Firm (KAP) of Makassar and secondary data conducted through the collection of data relevant to the auditor performance in the accuracy of the provision audit opinion. Data acquired both primary data and secondary data, processed and analyzed using qualitative data analysis. The results of research shows that: (1) Auditor performance in the accuracy of the provision audit opinion of KAP is already adequate. It was discernible from the audit report that has been presented in accordance with attestation standards of financial as well and in implementing the examination must first define the audit work program and procedures the have been designed in the standard of field activity. (2) Internal control for the auditor performance of in the audit opinion in KAP has been optimum visible on the auditor's work is with the separation of duties and responsibilities in accordance with predetermined and has the honesty and thoroughness in implementing their respective duties of auditors and disciplinary obeyed by the auditor who has the authority in providing audit opinion on the financial statements of clients conducted by auditors working in KAP Makassar.
EFFECT SOCIAL AND ENVIRONMENTAL ON FINANCIAL PERFORMANCE
Authors: Arsal Muryani , Hasanuddin Hasanuddin 
Published: March 2024

Laba merupakan salah satu aspek penentu kinerja keuangan, namun kadangkala untuk memaksimalkan laba, perusahaan tidak memperhatikan aspek lingkungan dan sosial yang akan berdampak kepada kerusakan lingkungan akibat limbah dan polusi dan juga tidak terjalinnya hubungan sosial dengan masyarakat. Penelitian ini bertujuan untuk mengetahui pengaruh pengungkapan kinerja sosial dan lingkungan terhadap kinerja keuangan PT. Indonesia Power. Data yang digunakan adalah data kinerja keuangan, kinerja sosial dan kinerja lingkungan mulai tahun 2007-2016. Hasil penelitian menunjukkan pengungkapan kinerja lingkungan dan kinerja sosial mempunyai pengaruh positif dan signifikan terhadap kinerja keuangan PT Indonesia Power sebesar 94.5%. Perusahaan telah mengungkapkan tanggungjawab social dan lingkungan yang meningkatkan kepercayaan masyarakat. Penelitian ini memberi kontribusi kepada manajemen PT Indonesia Power agar dapat mempertahankan dan meningkatkan kinerja lingkungan dan sosial yang telah dilakukan selama ini karena telah terbukti meningkatkan kinerja keuangannya.
Kata Kunci: social, lingkungan, kinerja keuangan

Abstract. Profit is one aspect of determining financial performance, but sometimes to maximize profits the company does not pay attention to environmental and social aspects that will have an impact on environmental damage such as pollution, waste and no relationship with social community. Therefore, this study aims to determine the effect of disclosure of social and environmental performance on the financial performance of PT. Indonesia Power. The data used are financial, social and environmental performance from 2007-2016. The results showed that disclosure of social and environmental has a positive and significant effect on the financial performance of PT Indonesia Power at 94.5%. The company has revealed social and environmental responsibilities that increase public trust. The study would contributes to the management of PT Indonesia Power to maintain and further improve the environmental and social performance that has been carried out so far because it has been proven to improve its financial performance.
Keywords:social, environmental, financial performance
Evaluation of nanoparticle albumin-bound paclitaxel loaded macrophages for glioblastoma treatment based on a microfluidic chip
Authors: Xie Zuorun , Ye Junyi , Gao Xinghua , Chen Hang , Chen Maosong , Lian Jiangfang , Ma Jingyun , Wang Hongcai 
Published: March 2024

Introduction: Glioblastoma (GBM) is a primary brain malignancy with a dismal prognosis and remains incurable at present. In this study, macrophages (MΦ) were developed to carry nanoparticle albumin-bound paclitaxel (nab-PTX) to form nab-PTX/MΦ. The aim of this study is to use a GBM-on-a-chip to evaluate the anti-GBM effects of nab-PTX/MΦ.Methods: In this study, we constructed nab-PTX/MΦ by incubating live MΦ with nab-PTX. We developed a microfluidic chip to co-culture GBM cells and human umbilical vein endothelial cells, mimicking the simplified blood-brain barrier and GBM. Using a syringe pump, we perform sustainable perfusion of nutrient media. To evaluate the anti-GBM effects nab-PTX/MΦ, we treated the GBM-on-a-chip model with nab-PTX/MΦ and investigated GBM cell proliferation, migration, and spheroid formation.Results: At the chosen concentration, nab-PTX did not significantly affect the viability, chemotaxis and migration of MΦ. The uptake of nab-PTX by MΦ occurred within 1 h of incubation and almost reached saturation at 6 h. Additionally, nab-PTX/MΦ exhibited the M1 phenotype, which inhibits tumor progression. Following phagocytosis, MΦ were able to release nab-PTX, and the release of nab-PTX by MΦ had nearly reached its limit at 48 h. Compared with control group and blank MΦ group, individual nab-PTX group and nab-PTX/MΦ group could inhibit tumor proliferation, invasion and spheroid formation. Meanwhile, the anti-GBM effect of nab-PTX/MΦ was more significant than nab-PTX.Discussion: Our findings demonstrate that nab-PTX/MΦ has a significant anti-GBM effect compared to individual nab-PTX or MΦ administration, suggesting MΦ as potential drug delivery vectors for GBM therapy. Furthermore, the developed GBM-on-a-chip model provides a potential ex vivo platform for innovative cell-based therapies and tailored therapeutic strategies for GBM.
Thrombocytopenia in Klebsiella pneumoniae liver abscess: a retrospective study on its correlation with disease severity and potential causes
Authors: Chen Lulu , Wang Hongguang , Wang Hairui , Guo Yawen , Chang Zhihui 
Published: March 2024

ObjectiveThrombocytopenia is commonly associated with infectious diseases and serves as an indicator of disease severity. However, reports on its manifestation in conjunction with Klebsiella pneumoniae liver abscess (KPLA) are scarce. The present study sought to elucidate the correlation between thrombocytopenia and KPLA severity and delve into the etiological factors contributing to the incidence of thrombocytopenia.Materials and methodsA retrospective analysis of the clinical data from patients with KPLA admitted between June 2012 and June 2023 was performed. Baseline characteristics, biochemical assessments, therapeutic interventions, complications, and clinical outcomes were compared between patients with and without thrombocytopenia. To investigate the potential etiologies underlying thrombocytopenia, the association between platelet count reduction and thrombophlebitis was examined, with a particular focus on platelet consumption. Furthermore, bone marrow aspiration results were evaluated to assess platelet production anomalies.ResultsA total of 361 KPLA patients were included in the study, among whom 60 (17%) had concurrent thrombocytopenia. Those in the thrombocytopenia group exhibited significantly higher rates of thrombophlebitis (p = 0.042), extrahepatic metastatic infection (p = 0.01), septic shock (p = 0.024), admissions to the intensive care unit (p = 0.002), and in-hospital mortality (p = 0.045). Multivariate analysis revealed that thrombocytopenia (odds ratio, 2.125; 95% confidence interval, 1.114–4.056; p = 0.022) was independently associated with thrombophlebitis. Among the thrombocytopenic patients, eight underwent bone marrow aspiration, and six (75%) had impaired medullar platelet production. After treatment, 88.6% of thrombocytopenic patients (n = 47) demonstrated recovery in their platelet counts with a median recovery time of five days (interquartile range, 3–6 days).ConclusionsThrombocytopenia in patients with KPLA is indicative of increased disease severity. The underlying etiologies for thrombocytopenia may include impaired platelet production within the bone marrow and augmented peripheral platelet consumption as evidenced by the presence of thrombophlebitis.
Iron deficiency: prevalence, mortality risk, and dietary relationships in general and heart failure populations
Authors: Sun Hui , Wang Qinhong , Han Wenqiang , Chen Changli , Wang Tianyu , Zhong Jingquan 
Published: March 2024

BackgroundIron deficiency (ID) is the most common nutritional deficiency, with little research on its prevalence and long-term outcomes in the general population and those with heart failure (HF). Both the relationships between dietary iron and ID, as well as dietary folate and ID, are understudied.MethodsWe used data from the National Health and Nutrition Examination Survey from 1999 to 2002 to investigate the prevalence, prognosis, and relationship between dietary and ID defined by different criteria in the general population (n = 6,660) and those with HF (n = 182).ResultsThere was no significant difference in the prevalence of ID between HF patients and the general population after propensity score matching. Transferrin saturation (TSAT) &lt;20% was associated with higher 5-year all-cause mortality (HR: 3.49, CI: 1.40–8.72, P = 0.007), while ferritin &lt;30 ng/ml was associated with higher 10-year (HR: 2.70, CI: 1.10–6.67, P = 0.031) and 15-year all-cause mortality (HR: 2.64, CI: 1.40–5.00, P = 0.003) in HF patients. Higher dietary total folate but dietary iron reduced the risk of ID (defined as ferritin &lt;100 ng/ml) in HF patients (OR: 0.80; 95% CI: 0.65–1.00; P = 0.047).ConclusionsThe prevalence of ID was identical in HF and non-HF individuals. Ferritin &lt;30 ng/ml was associated with long-term outcomes whereas TSAT &lt;20% was associated with short-term prognosis in both the general population and HF patients. A diet rich in folate might have the potential for prevention and treatment of ID in HF patients.
Association of HbA1c and utilization of internal mammary arteries with wound infections in CABG
Authors: Knochenhauer Tim , Schaefer Andreas , Brickwedel Jens , Reiter Beate , Naito Shiho , Zipfel Svante , Schneeberger Yvonne , Reichenspurner Hermann , Sill Bjoern 
Published: March 2024

BackgroundDeep sternal wound infection (DSWI) remains a serious complication after coronary artery bypass grafting (CABG). We herein aimed to stratify diabetic patients who underwent CABG using bilateral internal mammary artery (BIMA) for levels of glycated hemoglobin A1C (HbA1c) and compare postoperative outcomes.MethodsBetween January 2010 and August 2020, 4,186 consecutive patients underwent isolated CABG at our center. In 3,229 patients, preoperative HbA1c levels were available. Primary endpoints were wound healing disorder (WHD), DSWI, and 30-day mortality. Patients were stratified according to preoperative HbA1c levels. Patients were further divided into subgroups according to utilization of BIMA.ResultsAfter adjustment, no differences in mortality and stroke rates were seen between group 1 (HbA1c &lt; 6.5%) vs. group 2 (HbA1c ≥ 6.5%). WHD was more frequent in group 2 [2.8 vs. 5.6%; adjusted p = 0.002; adjusted odds ratio (OR), 1.853 (1.243–2.711)] but not DSWI [1.0 vs. 1.5%; adjusted p = 0.543; adjusted OR, 1.247 (0.612–2.5409)]. BIMA use showed a higher rate of WHD [no BIMA: 3.0%; BIMA: 7.7%; adjusted p = 0.002; adjusted OR, 4.766 (1.747–13.002)] but not DSWI [no BIMA: 1.1%; BIMA: 1.8%; adjusted p = 0.615; adjusted OR, 1.591 (0.260–9.749)] in patients with HbA1c ≥ 6.5%.ConclusionsIntraoperative utilization of BIMA is not connected with an increase of DSWI but higher rates of WHD in patients with poor diabetic status and HbA1c ≥ 6.5%. Therefore, application of BIMA should be taken into consideration even in patients with poor diabetic status, while identification of special subsets of patients who are at particular high risk for DSWI is of paramount importance to prevent this serious complication.
Assessing the causal relationship between gut microbiota and diabetic nephropathy: insights from two-sample Mendelian randomization
Authors: Fang Yipeng , Zhang Yunfei , Liu Qian , Zheng Zenan , Ren Chunhong , Zhang Xin 
Published: March 2024

BackgroundThe causal association between gut microbiota (GM) and the development of diabetic nephropathy (DN) remains uncertain. We sought to explore this potential association using two-sample Mendelian randomization (MR) analysis.MethodsGenome-wide association study (GWAS) data for GM were obtained from the MiBioGen consortium. GWAS data for DN and related phenotypes were collected from the FinngenR9 and CKDGen databases. The inverse variance weighted (IVW) model was used as the primary analysis model, supplemented by various sensitivity analyses. Heterogeneity was assessed using Cochran’s Q test, while horizontal pleiotropy was evaluated through MR-Egger regression and the MR-PRESSO global test. Reverse MR analysis was conducted to identify any reverse causal effects.ResultsOur analysis identified twenty-five bacterial taxa that have a causal association with DN and its related phenotypes (p &lt; 0.05). Among them, only the g_Eubacterium_coprostanoligenes_group showed a significant causal association with type 1 DN (p &lt; Bonferroni-adjusted p-value). Our findings remained consistent regardless of the analytical approach used, with all methods indicating the same direction of effect. No evidence of heterogeneity or horizontal pleiotropy was observed. Reverse MR analysis did not reveal any causal associations.ConclusionsThis study established a causal association between specific GM and DN. Our findings contribute to current understanding of the role of GM in the development of DN, offering potential insights for the prevention and treatment strategies for this condition.
Genetic overlap and causality between COVID-19 and multi-site chronic pain: the importance of immunity
Authors: Chen Yanjing , Liu Ping , Zhang Zhiyi , Ye Yingling , Yi Sijie , Fan Chunhua , Zhao Wei , Liu Jun 
Published: March 2024

BackgroundThe existence of chronic pain increases susceptibility to virus and is now widely acknowledged as a prominent feature recognized as a major manifestation of long-term coronavirus disease 2019 (COVID-19) infection. Given the ongoing COVID-19 pandemic, it is imperative to explore the genetic associations between chronic pain and predisposition to COVID-19.MethodsWe conducted genetic analysis at the single nucleotide polymorphism (SNP), gene, and molecular levels using summary statistics of genome-wide association study (GWAS) and analyzed the drug targets by summary data-based Mendelian randomization analysis (SMR) to alleviate the multi-site chronic pain in COVID-19. Additionally, we performed a latent causal variable (LCV) method to investigate the causal relationship between chronic pain and susceptibility to COVID-19.ResultsThe cross-trait meta-analysis identified 19 significant SNPs shared between COVID-19 and chronic pain. Coloc analysis indicated that the posterior probability of association (PPH4) for three loci was above 70% in both critical COVID-19 and COVID-19, with the corresponding top three SNPs being rs13135092, rs7588831, and rs13135092. A total of 482 significant overlapped genes were detected from MAGMA and CPASSOC results. Additionally, the gene ANAPC4 was identified as a potential drug target for treating chronic pain (P=7.66E-05) in COVID-19 (P=8.23E-03). Tissue enrichment analysis highlighted that the amygdala (P=7.81E-04) and prefrontal cortex (P=8.19E-05) as pivotal in regulating chronic pain of critical COVID-19. KEGG pathway enrichment further revealed the enrichment of pleiotropic genes in both COVID-19 (P=3.20E-03,Padjust=4.77E-02,hsa05171) and neurotrophic pathways (P=9.03E-04,Padjust =2.55E-02,hsa04621). Finally, the latent causal variable (LCV) model was applied to find the genetic component of critical COVID-19 was causal for multi-site chronic pain (P=0.015), with a genetic causality proportion (GCP) of was 0.60.ConclusionsIn this study, we identified several functional genes and underscored the pivotal role of the inflammatory system in the correlation between the paired traits. Notably, heat shock proteins emerged as potential objective biomarkers for chronic pain symptoms in individuals with COVID-19. Additionally, the ubiquitin system might play a role in mediating the impact of COVID-19 on chronic pain. These findings contribute to a more comprehensive understanding of the pleiotropy between COVID-19 and chronic pain, offering insights for therapeutic trials.