bluuebunny/crossref_metadata_2025_split huggingface dataset:
The birth-pangs of Portuguese Asia: revisiting the fateful ‘long decade’ 1498–1509
Authors: Subrahmanyam Sanjay 
Published: October 2007

AbstractThe essay sets out to re-examine the events and processes of inter-state and commercial competition that accompanied the arrival of the first Portuguese fleets in the Indian Ocean after the voyage of Vasco da Gama (1497–99). Focusing on the ‘long decade’ from 1498 to 1509, a series of differing perspectives on the challenges caused by the Portuguese to other rival powers is laid out and examined in detail. These include the Venetian conception of the Portuguese enterprise, which tended to be divided between an ‘optimistic’ view (suggesting that the Cape route would collapse quickly), and a more ‘pessimistic’ one, which saw the Serenissima itself as gravely threatened. The geo-political vision of Venetian observers, and the place given by them to the Vijayanagara empire in South India is duly noted with regard to the pepper trade in particular. This view is then contrasted with the abundant but uneven Portuguese documentation available from the time of the viceroyalty of Dom Francisco de Almeida (1505–09). The essay finally sets out to explain and contextualize the Mamluk maritime intervention in the affairs of the Red Sea and Indian Ocean, culminating in the defeat of the fleet of Amir Husain al-Kurdi off Diu in 1509.
We remind you that you should always take great care to send some men to discover (a descobryr), both to Melaka and to any other parts that are so far not that well-known, and you should send them with some goods in some local ships which are going there, so long as they can carry them safely. And those whom you send for this purpose should be men who know how to act upon it properly (devem ser homens que ho bem saybam fazer).Royal instructions to Dom Francisco de Almeida, 3 March 1505.1
The varieties of Sioux Christianity, 1860–1980, in international perspective
Authors: Lindenfeld David 
Published: October 2007

AbstractThe paper analyses the multiple ways in which the Sioux have dealt with missionary Christianity between roughly 1860 and 1980, placing this in an international perspective. It addresses the question of how and why Christianity became pervasive among the Sioux despite the avowed purpose of missionaries to extirpate Native culture. It contends that the churches willy-nilly preserved many elements of that culture and provided leadership opportunities for Natives that were not available through other institutions. It examines this process in the light of several interpretations of missionary encounters drawn from other cases, both in North America and Africa. While the Sioux exhibited a variety of ways of adapting to Christianity and combining it with their native religion, the most prominent strategy was dual participation, the simultaneous separate practice of the two.‘Most Sioux people maintain membership in, and belief in the efficacy of, some Christian denomination.’Raymond J. De Mallie and Douglas R. Parks, 19871‘A very small percentage of Native Americans are practicing Christians.’William Baldridge, 19932
Buddhism in the re-ordering of an early modern world: Chinese missions to Cochinchina in the seventeenth century
Authors: Wheeler Charles 
Published: October 2007

AbstractIn the seventeenth century, Chan Buddhist masters from monasteries in South China boarded merchant ships to Chinese merchant colonies in East and Southeast Asian port cities to establish or maintain monasteries. Typically, Chinese seafarers and merchants sponsored their travel, and sovereigns and elites abroad offered their patronage. What were these monks and their patrons seeking? This study will investigate the question through the case of one Chan master, Shilian Dashan, who journeyed to the Vietnamese kingdom of Cochinchina (Dang Trong) in 1695 and 1696. In Dashan, we see a form of Buddhism thought to have vanished with the Silk Road: that is, Buddhism as a ‘missionary religion’ able to propagate branch temples through long-distance networks of merchant colonies, and to form monastic communities within the host societies that welcomed them. This evident agency of seafaring Chan monks in early modern times suggests that Buddhism’s role in commerce, diaspora, and state formation in early modern maritime Asia may compare to religions like Islam and Christianity, and deserves further study.
Indian Nationalism and the ‘world forces’: transnational and diasporic dimensions of the Indian freedom movement on the eve of the First World War
Authors: Fischer-Tiné Harald 
Published: October 2007

AbstractThe present article takes a global perspective on the diasporic networks of Indian revolutionaries that were emerging on the eve of the First World War. It looks particularly at three important headquarters of their activities, namely London, New York and Tokyo. The narrative is centred on the ‘India Houses’ that were opened in these three cities and served as the institutional umbrella units for the revolutionary schemes. Finally, the political alliances forged and the ideological resources tapped in these three settings are sketched out and briefly analysed. The case study makes two points: to begin with, it is important to extend historical scrutiny beyond the geographical bounds of India to fully grasp the development of Indian nationalism in this first peak time of globalization; second, the existence of the sophisticated transnational anti-imperial propaganda networks that are the focus of this study raises doubts about the alleged watershed character of the First World War as the ‘global moment’ that decisively shook the imperial world order. The year 1905, it is argued, was at least as important in this regard.
The dematerialization of telecommunication: communication centres and peripheries in Europe and the world, 1850–1920
Authors: Wenzlhuemer Roland 
Published: October 2007

AbstractInterregional communication has been a key constituent of the process of globalization since its very origins. For most of its history, information has moved between world regions and along the routes according to the rationales established by interregional trade and migration. The dematerialization of telecommunication in the late eighteenth and nineteenth century eventually detached long-distance information transmission from transport and transformed the global communication structure. New communication centres (and new peripheries) emerged. Some regions moved closer to the global data stream than others. It is still unclear how such different degrees of global connectivity impacted on local development. This essay contributes to the identification and valuation of global communication centres and peripheries in order to provide suitable candidates for future case studies. To this end, statistical data on the development of domestic telegraph networks in selected countries has been analysed and interpreted. In a second step, Social Network Analysis methods have been employed to measure the centrality of almost three hundred cities and towns in the European telecommunication network of the early twentieth century.‘You cannot not communicate.’Paul Watzlawick
The two prime movers of globalization: history and impact of diesel engines and gas turbines
Authors: Smil Vaclav 
Published: October 2007

AbstractModern economic globalization would be impossible without our ability to move billions of tonnes of raw materials and finished goods among the continents and to fly at speeds approaching the speed of sound. These realities were made possible by the interaction of economic and technical factors. Much has been written about their organizational and political underpinnings (ranging from the role of multinational corporations to the history of free trade agreements), but much less on the history of the two prime movers that made these realities possible. Neither steam engines, nor gasoline-fuelled engines could have accomplished comparable feats. Diesel engines made ocean shipping the cheapest mode of long-distance transport and without gas turbines there would be no fast, inexpensive, mass-scale intercontinental travel. This paper examines the history, advances, benefits and costs of the two prime movers.
Investigating the Feasibility of Stem Cell Enrichment Mediated by Immobilized Selectins
Authors: Charles Nichola , Liesveld Jane L. , King Michael R. 
Published: October 2007

AbstractHematopoietic stem cell therapy is used to treat both malignant and non‐malignant diseases, and enrichment of the hematopoietic stem and progenitor cells (HSPCs) has the potential to reduce the likelihood of graft vs host disease or relapse, potentially fatal complications associated with the therapy. Current commercial HSPC isolation technologies rely solely on the CD34 surface marker, and while they have proven to be invaluable, they can be time‐consuming with variable recoveries reported. We propose that selectin‐mediated enrichment could prove to be a quick and effective method for recovering HSPCs from adult bone marrow (ABM) on the basis of differences in rolling velocities and independently of CD34 expression. Purified CD34+ ABM cells and the unselected CD34– ABM cells were perfused over immobilized P‐, E‐, and L‐selectin‐IgG at physiologic wall shear stresses, and rolling velocities and cell retention data were collected. CD34+ ABM cells generally exhibited lower rolling velocities and higher retention than the unselected CD34– ABM cells on all three selectins. For initial CD34+ ABM cell concentrations ranging from 1% to 5%, we predict an increase in purity ranging from 5.2% to 36.1%, depending on the selectin used. Additionally, selectin‐mediated cell enrichment is not limited to subsets of cells with inherent differences in rolling velocities. CD34+ KG1a cells and CD34– HL60 cells exhibited nearly identical rolling velocities on immobilized P‐selectin‐IgG over the entire range of shear stresses studied. However, when anti‐CD34 antibody was co‐immobilized with the P‐selectin‐IgG, the rolling velocity of the CD34+ KG1a cells was significantly reduced, making selectin‐mediated cell enrichment a feasible option. Optimal cell enrichment in immobilized selectin surfaces can be achieved within 10 min, much faster than most current commercially available systems.
Reactome - a knowledgebase of human biological pathways
Authors: D'Eustachio Peter , Croft David , de Bono Bernard , Gopinath Gopal , Gillespie Marc , Jassal Bijay , Matthews Lisa , Schmidt Esther , Vastrik Imre , Wu Guanming , Lewis Suzanna , Birney Ewan , Stein Lincoln 
Published: October 2007

AbstractPathway curation is a powerful tool for systematically associating gene products with functions. Reactome (www.reactome.org) is a manually curated human pathway knowledgebase describing a wide range of biological processes in a computationally accessible manner. The core unit of the Reactome data model is the Reaction, whose instances form a network of biological interactions through entities that are consumed, produced, or act as catalysts. Entities are distinguished by their molecular identities and cellular locations. Set objects allow grouping of related entities. Curation is based on communication between expert authors and staff curators, facilitated by freely available data entry tools. Manually curated data are subjected to quality control and peer review by a second expert. Reactome data are released quarterly. At release time, electronic orthology inference performed on human data produces reaction predictions in 22 species ranging from mouse to bacteria. Cross-references to a large number of publicly available databases are attached, providing multiple entry points into the database. The Reactome Mart allows query submission and data retrieval from Reactome and across other databases. The SkyPainter tool provides visualization and statistical analysis of user supplied data, e.g. from microarray experiments. Reactome data are freely available in a number of data formats (e.g. BioPax, SBML).
Is the infection/latency/reactivation cycle of viruses an oncogenic engine?
Authors: Ripalti Alessandro 
Published: October 2007

AbstractHuman oncogenic viruses are defined as necessary but not sufficient to initiate cancer. Experimental evidence suggests that the oncogenic potential of a virus is effective only in cells that have already accumulated a number of genetic mutations leading to cell cycle deregulation. Current models for viral driven oncogenesis cannot explain why tumor development in carriers of tumorigenic viruses is a very rare event, occurring decades after virus infection. Considering that viruses are mutagenic agents per se and human oncogenic viruses additionally establish latent and persistent infections, I attempt here to provide a mechanism of tumor initiation both for RNA and DNA viruses, suggesting viruses could be both necessary and sufficient in human tumorigenesis. I hypothesize a general, albeit inefficient hit and rest mechanism by which viruses may produce a limited reservoir of cells harbouring genetic damage that would be initiated when the virus first hits the cell, before latency is established. Cells surviving genetic damage would consequently become more sensitive to further damage mediated by the otherwise insufficient transforming activity of virus products expressed in latency, or upon episodic reactivations (viral persistence). Cells with a combination of genetic damage leading to a cancerous phenotype would emerge very rarely, as the probability of such an occurrence would be dependent on severity and frequency of consecutive hit and rest cycles due to viral reinfections and reactivations.
Preventing Fatalities in Building Bombings: What Can We Learn From the Oklahoma City Bombing?
Authors: Glenshaw Mary T. , Vernick Jon S. , Li Guohua , Sorock Gary S. , Brown Sheryll , Mallonee Sue 
Published: October 2007

ABSTRACTBackground: Bombings are an increasing threat to the public's health. Descriptive studies of blast injuries have been published, but these injuries have not been studied using analytical epidemiological methods. This study assesses factors associated with fatality risk among individuals exposed to the 1995 Oklahoma City bombing.Methods: Retrospective case-control analysis using multivariable logistic regression. Odds ratios (OR) of fatality are calculated among occupants of the Alfred P. Murrah Federal Building on April 19, 1995.Results: Of the 348 occupants exposed, 163 (46.8%) were fatally injured. Fatality risk was greatest in the collapsed region of the building (adjusted OR 176.7, 95% confidence interval [CI] 65.9–474.2). Age ≥40 was also associated with a significantly increased risk of fatality (OR 3.7, 95% CI 1.4–9.8). Among people found in the noncollapsed region of the building, employees' status compared to a visitor's or child's status was protective (OR 0.13, 95% CI 0.01–1.3)Conclusions: Structural collapse is the most important risk factor for fatality in a building bombing. Progressive collapse may be prevented through more supportive building design. Protection of vulnerable building occupants can be improved by placement of relevant facilities in more structurally reinforced areas. Regular evacuation training of personnel and clear egress routes may also reduce fatality in a building bombing. (Disaster Med Public Health Preparedness. 2007;1:27–33)
Protecting the Public's Health Following the Virginia Tech Tragedy: Issues of Law and Policy
Authors: Hodge James G. 
Published: October 2007

ABSTRACTAssessing legal responsibility in the aftermath of the April 2007 tragedy at Virginia Polytechnic Institute and State University (Virginia Tech) is inevitable. Beyond assigning blame, law- and policymakers should examine ways to protect the public from future incidences of gun violence on campuses and other settings. Although no combination of legal responses may fully deter individuals who are intent on causing significant harm, select legal reforms have the potential to prevent future acts of gun violence. These reforms include considering more restrictive gun laws nationally, reporting individuals with known mental impairments that may endanger themselves or others to federal or state databases, and refining laws that limit institutions from acting in advance to address prospectively dangerous people. Each of these reforms has the potential to reduce acts of gun violence to improve the public's health, but also implicates individual rights and interests. (Disaster Med Public Health Preparedness. 2007;1(Suppl 1):S43–S46)
Developing a Consensus Framework for an Effective and Efficient Disaster Response Health System: A National Call to Action
Authors: Lyznicki James , Subbarao Italo , Benjamin Georges C. , James James J. 
Published: October 2007

ABSTRACTEighteen national organizations, representing medicine, dentistry, nursing, hospital systems, public health, and emergency medical services, have worked together to create a framework for a national and regional disaster response health system that is scalable, multidisciplinary, and seamless, and based on an all-hazards approach. In July 2005 and June 2006 the American Medical Association (AMA) and the American Public Health Association (APHA) convened the AMA/APHA Linkages Leadership Summit, with funding from the Centers for Disease Control and Prevention under the Terrorism Injuries: Information Dissemination and Exchange (TIIDE) program. As cofacilitators, James J. James, MD, DrPH, MHA, director of the AMA Center for Public Health Preparedness and Disaster Response, and Georges Benjamin, MD, FACP, FACEP(E), APHA executive director, met with leaders from 16 national medical, dental, hospital, nursing, hospital systems, public health, and emergency medical services organizations in Chicago (2005) and New Orleans (2006) to deliberate the deficiencies in the medical and public health disaster response system and the lack of necessary linkages between key components of this system: the health care, emergency medical services, and public health sectors. The goal was to reach consensus on a set of overarching recommendations to improve and sustain health system preparedness and to combine each organization's advocacy expertise and experience to promote a shared policy agenda. The full summit report contains 53 consensus-based recommendations, which will serve as the framework for a coordinated national agenda for strengthening health system preparedness for terrorism and other disasters. The 9 most overarching critical recommendations from the report are highlighted here. Although the summit report presents important perspectives on the subject of preparedness for public health emergencies, we must understand that preparedness is a process and that these recommendations must be reviewed and refined continually over time. (Disaster Med Public Health Preparedness. 2007;1(Suppl 1):S51–S54)
Preventing Tragedy: Balancing Physicians' Ethical Obligations to Patients and the Public
Authors: Anderson Emily E. , Black Lee J. , Bostick Nathan A. 
Published: October 2007

ABSTRACTThe recent shootings at Virginia Polytechnic Institute and State University (Virginia Tech) suggest that an increased reliance upon the medical community to support public health violence prevention efforts may be warranted. As physicians are called upon to support these efforts, they must effectively balance their obligations to promote public safety with their traditional obligations to promote the best interests of their individual patients. To meet these concurrent ethical obligations, physicians' participation in public health violence prevention should seek to improve public safety without compromising the care of patients or exposing individuals to undue harm. Physicians should, therefore, report to the appropriate authorities those patients who are at risk of committing violent acts toward the public, but should only disclose the minimal amount of information that is necessary to protect the public. Moreover, physicians should also recommend the separation of violent individuals from the community at large when necessary to improve public safety while advocating for the provision of appropriate treatment measures to improve the patients' well-being. (Disaster Med Public Health Preparedness. 2007;1(Suppl 1):S38–S42)
Regional Health System Response to the Virginia Tech Mass Casualty Incident
Authors: Kaplowitz Lisa , Reece Morris , Hershey Jody Henry , Gilbert Carol M. , Subbarao Italo 
Published: October 2007

ABSTRACTBackground: On April 16, 2007 a mass shooting occurred on the campus of Virginia Polytechnic Institute and State University (Virginia Tech). Due to both distance and weather, air transport of the injured directly to a level 1 trauma center was not possible. The injured received all of their care or were initially stabilized at 3 primary hospitals that either had a level 3 trauma center designation or no trauma center designation.Methods: This article is a retrospective analysis of the regional health system (prehospital, hospital, regional hospital emergency operations center, and public health local and state) response. Data records from all of the regional responding emergency medical services, hospitals, and coordinating services were reviewed and analyzed. Records for all 26 patients were reviewed and analyzed using triage designations, injury severity scores (ISS), and critical mortality.Results: Twenty-five of the 26 patients were triaged in the field. Excluding 1 patient (asthma), the average ISS for victims presenting was 8.2. Twelve patients had an ISS of ≥9, and 5 had an ISS score of ≥15. Ten of the 26 patients (38%) required urgent intervention and surgery in the first 24 hours. The overall regional health system mortality of victims received was 3.8% (1 death [excluding 1 dead on arrival {DOA}]/ 26 victims from scene). The regional health system critical mortality rate (excluding 1 victim who was DOA) was 20% (1/5).Discussion: The outcomes of the Virginia Tech mass casualty incident, as evidenced by the low overall regional health system mortality of victims received at 3.8% (1/26) and low critical mortality rate (excluding 1 victim who was DOA) of 20%, coupled with a need to treat a significant amount of moderately injured victims 46% (12/26 with ISS ≥9) gives credence to the successful response. The successful response occurred as a consequence of regional collaborative planning, training, and exercising, which resulted not only in increased expertise and improved communications but also in essential relationships and a sense of trust forged among all of the responders. (Disaster Med Public Health Preparedness. 2007;1(Suppl 1):S9–S13)
State of Security at US Colleges and Universities: A National Stakeholder Assessment and Recommendations
Authors: Greenberg Sheldon F. 
Published: October 2007

ABSTRACTIn 2004 the US Department of Justice, Office of Community Oriented Policing Services, sponsored a National Summit on Campus Public Safety. The summit brought together various stakeholders including campus police and security officials, local police chiefs, college and university faculty and administrators, federal officials, students and parents, and community leaders to address the issues and complexities of campus safety. Delegates to the summit identified key issues in campus safety and security, which included establishing a national center on campus safety, balancing traditional open environments with the need to secure vulnerable sites, improving coordination with state and local police, reducing internal fragmentation, elevating professionalism, and increasing eligibility of campus police and security agencies to compete for federal law enforcement funds. Focus on “active shooters” on campus, resulting from the Virginia Tech incident, should not diminish attention placed on the broader, more prevalent safety and security issues facing the nation's educational campuses. Recommendations resulting from the summit called for establishing a national agenda on campus safety, formation of a national center on campus public safety, and increased opportunity for campus police and security agencies to compete for federal and state funds. (Disaster Med Public Health Preparedness. 2007;1(Suppl 1):S47–S50)