bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systematic Contact-Free 3D Topometry of the Soft Tissue Profile in Cleft Lips
Authors: Schwenzer-Zimmerer Katja , Chaitidis Despina , Boerner Isabelle , Kovacs Laszlo , Schwenzer Nina F. , Holberg Christof , Zeilhofer Hans-Florian 
Published: October 2008

Objective: To evaluate the clinical application of three-dimensional (3D) imaging for the analysis of a broad variety of cleft lips and to conduct a systematic analysis. Design: This was a prospective study using a noncontact 3D laser scanner to acquire the preoperative 3D facial profiles. The data sets were analyzed qualitatively and quantitatively. The data were expressed by ratios and scores. Patients: Forty nonsedated patients (1 to 39 years, average age 2.7 years) with unilateral cleft lip, cleft lip and alveolus, or complete unilateral cleft in Cambodia. Results: The acquired 3D data sets (mean acquisition time: 2.5 seconds) from facial surfaces were of diagnostic quality in 27 of 40 patients (average age, 14.2 years). In these cases all anatomical structures could be mapped precisely by means of landmark positioning in the range of millimeters. A new method of systematic analysis could be elaborated, allowing for data set expression independent of size and growth factors. In children under age 3, the measuring procedure was of limited value because of motion artifacts and was successful in only 6% (1 of 15) of these patients. Conclusion: The system offers a solid and precise tool for 3D imaging of the complex cleft lip anatomy in compliant patients and is useful for preoperative cleft assessment and follow-up. However, the application is limited in moving infants or uncooperative adults because of scanning time and acquisition method. The development of motion tracking and faster devices could eliminate motion artifacts.
A New Grading of Pierre Robin Sequence
Authors: Cole Annie , Lynch Patricia , Slator Rona 
Published: October 2008

Objective: Pierre Robin sequence (PRS) involves the triad of micrognathia, glossoptosis, and cleft palate. Neonates with PRS suffer from two problems—airway obstruction and feeding difficulties—but the severity of these problems varies greatly. The resultant varying definitions of PRS have resulted in inconsistent management of those babies given the diagnosis. This in turn makes comparison of published data and communication between clinicians difficult. Historically at Birmingham Children's Hospital, the cleft team only identified babies presenting with cleft palate and severe respiratory distress as “true” PRS. These babies were admitted to the high-dependency neonatal ward for airway assessment and management. Babies with a mild degree of respiratory obstruction but who were managed successfully at home were not classified as having PRS despite needing considerable input from the Cleft Clinical Nurse Specialist. A system of classifying babies with PRS based on the severity of their symptoms and signs and treatment required was therefore devised and is described in this paper. Results: Since implementation, this new classification of babies with PRS into three grades has clarified care pathways and enhanced communication between the Cleft Clinical Nurse Specialists and other health professionals involved with the care of these babies.
Craniofacial Morphology of Dutch Patients with Bilateral Cleft Lip and Palate and Noncleft Controls at the Age of 15 Years
Authors: van den Dungen Geer M. , Ongkosuwito Edwin M. , Aartman Irene H. A. , Prahl-Andersen Birte 
Published: October 2008

Objective: Comparison of craniofacial morphology in bilateral cleft lip and palate patients to that of a noncleft control group at the age of 15 years. Design: A cross-sectional study of cephalometric data. Subjects and Methods: Cephalometric records of 41 consecutive patients (32 boys and 9 girls) with nonsyndromic complete bilateral cleft lip and palate born between 1973 and 1987. The patients were treated by the cleft teams of the Erasmus Medical Centre in Rotterdam and the VU University Amsterdam. The control group of normal Dutch subjects was followed in the Nijmegen Growth Study. From this population, mean cephalometric data were used. Differences in cephalometric measurements and other variables were calculated between the bilateral cleft lip and palate group and the control group. Results: Independent-sample t tests indicated that there was a statistically significant difference between the mean of the cephalometric values of the bilateral cleft lip and palate patients and the control group with respect to all cephalometric variables. Pearson correlation coefficients calculated between angle ANB and the number of operators, number of surgical procedures before 15 years of age, and the year of birth were not significant. Conclusions: Bilateral cleft lip and palate patients treated in the Amsterdam and Rotterdam cleft centers differed significantly from the control group in all measurements. A Class III development due to a less forward positioned maxilla was observed. The vertical measurements indicated a more divergent growth pattern in bilateral cleft lip and palate patients (Ans-Me/N-Me, GoGn-SN, and SN-FFH).
Cleft Lip and/or Palate: 10 Years Experience at a Pediatric Cleft Center in Southern Thailand
Authors: Jaruratanasirikul Somchit , Chichareon Vichai , Pattanapreechawong Nuria , Sangsupavanich Pasuree 
Published: October 2008

Objective: To study the clinical characteristics, demographic data, and associated congenital anomalies of pediatric patients with cleft lip and/or palate in Southern Thailand. Design: Retrospective, hospital-based study. Setting: Cleft Clinic Center, Songklanagarind Hospital Participants: Children with cleft lip and/or palate who were born or seen at Songklanagarind Hospital between January 1997 and December 2006. Main Outcome Measure: Clinical features including demographic data, types of cleft, associated anomalies, family history of clefts, and physical growth. Results: A total of 153 children were seen during the studied period, of whom 36 (23.5%) had isolated cleft lip, 32 (20.9%) had isolated cleft palate, and 85 (55.6%) had combined cleft lip and palate. Twenty-seven children (17.7%) had a family history of clefts. Congenital malformations (syndromic cleft) were found in 20 children (13%), and chromosomal abnormalities were found in four of these (20%). There were no significant differences among the three groups (isolated cleft lip, isolated cleft palate, and combined cleft lip and palate) in maternal and paternal ages, gestational age, birth weight, family history of cleft, or associated malformations. The physical growth parameters of children with nonsyndromic cleft were the same as in the general population. Children with syndromic cleft were significantly lighter at birth and had grown up significantly shorter and lighter, with smaller head circumference. Conclusions: Chromosomal abnormalities are commonly found in children with syndromic cleft. Children with nonsyndromic cleft have normal growth; whereas, those with syndromic cleft have some degree of prenatal and postnatal growth restriction.
The Effect of Nasal Decongestion on Nasal Patency and Nasalance Scores in Subjects with Normal Speech
Authors: Watterson Thomas , Lewis Kerry E. , Ludlow Jennifer C. , Ludlow Paul C. 
Published: October 2008

Objective: The objective of this study was to evaluate the effects of pharmacological decongestion on nasalance scores. Participants: The participants were 20 adults with normal speech and resonance. Methods: Nasal patency was first determined by measuring the mean minimal cross-sectional area of the nasal passages by acoustic rhinometry. Each participant then read two passages as two predecongestion nasalance scores were obtained. A nasal decongestant was then administered to each nostril without removing the separation plate. Ten minutes later, nasalance scores were repeated. Finally, the separation plate was removed and the mean minimal cross-sectional area was obtained again. Main Outcome Measures: The outcome measures were the pre- and postdecongestion measurements of nasal patency and nasalance scores. Results: Minimal cross-sectional area increased significantly from 0.53 cm2 before decongestion to 0.66 cm2 after decongestion. For the Turtle Passage, the group mean nasalance for the two predecongestion measures (10.70% versus 11.55%) were significantly different and the pre- versus postdecongestion measures (10.70% versus 12.15%) were also significantly different. For the Mouse Passage, the group mean nasalance scores for the two predecongestion measures (32.10% versus 32.00%) were not significantly different but the pre- versus postdecongestion means (32.10 versus 34.40) were significantly different. Correlation coefficients showed a negligible relationship between measures of nasal patency and nasalance scores for both stimulus passages. Conclusions: Nasalance score variability was small and not meaningful for standard clinical purposes. The correlation between nasalance scores and nasal patency was weak.
Adjusting global extinction rates to account for taxonomic susceptibility
Authors: Wang Steve C. , Bush Andrew M. 
Published: October 2008

Studies of extinction in the fossil record commonly involve comparisons of taxonomic extinction rates, often expressed as the percentage of taxa (e.g., families or genera) going extinct in a time interval. Such extinction rates may be influenced by factors that do not reflect the intrinsic severity of an extinction trigger. Two identical triggering events (e.g., bolide impacts, sea level changes, volcanic eruptions) could lead to different taxonomic extinction rates depending on factors specific to the time interval in which they occur, such as the susceptibility of the fauna or flora to extinction, the stability of food webs, the positions of the continents, and so on. Thus, it is possible for an extinction event with a higher taxonomic extinction rate to be caused by an intrinsically less severe trigger, compared to an event with a lower taxonomic extinction rate.Here, we isolate the effects of taxonomic susceptibility on extinction rates. Specifically, we quantify the extent to which the taxonomic extinction rate in a substage is elevated or depressed by the vulnerability to extinction of classes extant in that substage. Using a logistic regression model, we estimate that the taxonomic susceptibility of marine fauna to extinction has generally declined through the Phanerozoic, and we adjust the observed extinction rate in each substage to estimate the intrinsic extinction severity more accurately. We find that mass extinctions do not generally occur during intervals of unusually high susceptibility, although susceptibility sometimes increases in post-extinction recovery intervals. Furthermore, the susceptibility of specific animal classes to extinction is generally similar in times of background and mass extinction, providing no evidence for differing regimes of extinction selectivity. Finally, we find an inverse correlation between extinction rate within substages and the evenness of diversity of major taxonomic groups, but further analyses indicate that low evenness itself does not cause high rates of extinction.
A novel triply bridged dinuclear four-coordinate copper(I) complex with sterically bulky bis(dicyclohexylphosphino)methane ligand
Authors: Yao Zu-Fu , Gan Xin , Fu Wen-Fu 
Published: October 2008

Abstract
A novel triply bridged dinuclear copper(I) complex: Cu2(μ-paa)(μ-dcpm)2(BF4)2·2CH2Cl2 [ paa = pyridine-2-carbaldehyde azine (C12H10N4) and dcpm = bis(dicyclohexylphosphino)methane(C25H46P2) ] has been synthesized and structurally characterized. Crystallographic studies of the complex showed that two copper(I) ions were bridged by one paa ligand and two dcpm ligands. The paa ligand adopted the Z configuration at the partially double N-N bond and the two copper ions have distorted tetrahedral coordination geometry. Because of the steric effect of dcpm, the pyridine rings of the paa ligand are obviously not on the same plane (the dihedral angle is 43.610). The interaction between neighboring ligands results in a N-N bond length (1.374(7) Å) contraction. The UV-vis spectra of the complex exhibited intense high-energy absorptions at λmax
Synthesis, characterization and antifungal testing of 3,4-dihydropyrimidin-2(1H)-(thio)ones containing boronic acids and boronate esters
Authors: Duguay Dominique , Zamora Matthew , Blacquiere Johanna , Appoh Francis , Vogels Christopher , Wheaton Susan , Baerlocher Felix , Decken Andreas , Westcott Stephen 
Published: October 2008

Abstract
The addition of formylphenylboronic acid derivatives to thiourea and ethyl acetoacetate proceeds in the presence of an additional Lewis acid catalyst to give the corresponding 3,4-dihydropyrimidin-2(1H)-(thio)ones (Biginelli products) in moderate yield. Compounds were tested for antifungal activity against pure cultures of Aspergillus niger, Aspergillus flavus, Candida albicans and Saccharomyces cerevisiae but, unfortunately, none showed any appreciable activity.
Uses of 5-Methylresorcin-bonded polyurethan foam as a new solid phase extractor for the selective separation of mercury ions from natural water samples
Authors: Burham N. 
Published: October 2008

Abstract
In this work, 5-Methylresorcin (MR) bonded to untreated polyurethane foam (PUF) was successfully employed as a sorbent (MR-PUF) for the selective separation and determination of mercury in natural water samples. Mercury can be quantitatively recovered in the pH range of 5-7. The system presented a minicolumn packed with the new sorbent, where the sample solution was passed through it for a period of time and an eluent solution stripped out the retained mercury, which was further determined with dithizone. The new matrix was characterized by using different tools (IR spectra, stability and density). The kinetics of mercury uptake by the new matrix was found to be fast, reaching equilibrium in 20 minutes. A preconcentration factor of 350 was achieved. The proposed preconcentration procedure was applied successfully to the selective separation and determination of trace mercury in natural water samples.
Nanosized centers for mercury(II) ions adsorption on a surface of modified silica
Authors: Belyakova Lyudmila , Shvets Oleksandra , Lyashenko Diana 
Published: October 2008

Abstract
The present work investigates the adsorptive interactions of Hg(II) ions in aqueous medium with hydroxylated silica, aminopropylsilica and silica chemically modified by β-cyclodextrin. Batch adsorption studies were carried out with various agitation times and mercury(II) concentrations. The maximum adsorption was observed within 15–30 min of agitation. The kinetics of the interactions, tested with the model of Lagergren for pseudo-first and pseudo-second order equations, showed better agreement with first order kinetics (k1 = 3.4 ± 0.2 to 5.9 ± 0.3 min−1). The adsorption data gave good fits with Langmuir isotherms. The results have shown that β-cyclodextrin-containing adsorbent has the largest adsorption specificity to Hg(II): K L = 4125 ± 205 mmol−1. “β-cyclodextrin-NO3-” inclusion complexes with ratio 1: 1 and super molecules with composition C42H70O35 ⊎ 3 Hg(NO3)2 are formed on the surface of β-cyclodextrin-containing silica.
Preliminary results of a quick, simple method of detecting antimony in water samples
Authors: Díaz-Pérez Mónica , Aboal-Somoza Manuel , Bermejo-Barrera Pilar , Bermejo-Barrera Adela 
Published: October 2008

Abstract
Preliminary results of development of a direct and fast method of determination of antimony in samples of tap water using GFAAS are presented. The found levels of antimony were lower than permitted for human consumption. A mixture of Pd and Mg(NO3)2 (concentrations in the injected solution: 8.6 μg mL−1 and 5.8 μg mL−1 respectively) was used as the chemical modifier. The pyrolysis and atomization temperatures were 1000 and 1700°C, respectively and the mean analytical recovery 98.2%.
Synthesis of SnO2 nanopowders by a sol-gel process using propanol-isopropanol mixture
Authors: Hassanzadeh Ali , Moazzez Behrang , Haghgooie Hossein , Nasseri Mohsen , Golzan Mir , Sedghi Hassan 
Published: October 2008

Abstract
A simple sol-gel process is proposed for synthesizing SnO2 nanopowders utilizing normal propanol and isopropanol mixture instead of just using normal alcohols such as ethanol, propanol or butanol for Sol preparation. No surfactant was used in this Sol preparation process. The structure of sol is studied by FT-IR-ATR technique. On altering propanol to isopropanol ratio, three different nanopowders were obtained. X-ray powder diffraction, high-resolution transmission electron microscopy (HRTEM), selected area electron diffraction pattern (SAED) and BET techniques were used to characterize prepared powders. Results show that smaller grain size was obtained via altering alcohols ratio. In addition, Merck commercial SnO2 powder was also used as a reference material for comparing purposes; because it has nanometer scale (ca. 60 nm). HRTEM images show that obtained nanopowders were polycrystalline and their average diameters fall into the range of 6–80 nm. Finally, the effect of alkoxide ligand size through sol-gel synthesis on product particle size is discussed.
Study of multiblock polyamide-6/Poly-(isoprene) copolymers by positron annihilation spectroscopy
Authors: Bryaskova R. , Mateva R. , Djourelov N. , Krasteva M. 
Published: October 2008

Abstract
Positron annihilation lifetime spectroscopy (PALS) has been used to determine the free volume in multiblock polyamide-6/poly-(isoprene) copolymers (PA-6/PI), synthesized via activated anionic bulk copolymerization. The diisocyanate functionalized telechelic PI, blocked with caprolactam (CL) has been used as a commoner and an activator at the same time. The elastic PI block incorporated into the main chain of PA-6 affects the amorphous and crystal phase of the copolymer leading to changing in degree of crystallinity. The positron annihilation lifetime spectroscopy (PAL) and Doppler broadening of annihilation line (DBAL) technique in a set of pure PA-6 and PA-6/PI copolymers with two different compositions have been applied and evaluation of the size of free-volume holes (pores), localized mainly in the disordered regions of the PA-6/PI copolymer by measuring the o-Ps lifetime (τ3) and o-Ps intensity (I3) has been performed.
Tensile strengths and Young’s modulus of thin copper and copper-nickel (CuNi44) substrates
Authors: Staller Oliver , Mitterbauer Christina , Mayr Katharina 
Published: October 2008

Abstract
In this paper we report a method to determine tensile strengths and Young’s modulus of cubic biaxial textured metal tapes used as substrate materials for coated conductors (CC). Simplicity, rapidity and reproducibility of the procedure are important for the evaluation of continuous in-house productions. Our approach is based on the EN 10002-1 B tensile test method. A key role for satisfactory results is the sample preparation of 100–250 μm thick tapes, which will be described in detail. Copper (E-Cu57) can be successfully transformed to cubic biaxial textured substrates. Best results were achieved by annealing between 750°C and 850°C in reducing atmosphere. Best FWHM values for the ψ scan are 5.51° and for the ϕ scan are 4.5°. Pole figure analysis verified the sharp {001} texture of the tape. Vickers hardness measurements (HV 0.1) for the cold worked material yielded values of 135 and for the annealed tape, values of 37. The ultimate tensile yield strength Rm of the textured substrate is 150 MPa and thus significantly lower than that for the cold worked material (413 MPa). Cubic biaxial substrates could be manufactured from Isotan CuNi44 (WM49) bars. Best results were achieved by annealing at 1200°C in reducing atmosphere. Pole figure analysis verified the {001} texture with other low intensity texture components. Vickers hardness measurements (HV 0.1) for the cold worked material yielded values of 236 and for the annealed tape values of 92. The ultimate tensile yield strength R m of the textured substrate is 300 MPa and thus significantly lower than that for the cold worked material (723 MPa).
Gene Transfer into Neural Cells In Vitro Using Adenoviral Vectors
Authors: Southgate Thomas , Kroeger Kurt M. , Liu Chunyan , Lowenstein Pedro R. , Castro Maria G. 
Published: October 2008

AbstractAdenoviral vectors are excellent vehicles to transfer genes into the nervous system due to their ability to transduce dividing and nondividing cells, their ability to be grown to very high titers, and their relatively large insert capacity. Also, adenoviral vectors can sustain very long‐term transgene expression in the CNS of rodents and in neurons and glial cells in culture. Successful gene transfer into the nervous system is dependent on the development, production, and quality control of vector preparations, which need to be of the highest quality. This unit provides protocols to clone, rescue, amplify, and purify first‐generation adenoviral vectors. Detailed quality control assays are provided to ensure that vector preparations are devoid of contamination from replication‐competent adenovirus and lipopolysaccharides. Also included are methodologies related to adenoviral‐mediated gene transfer into neurons and glial cells in culture, and the analysis of transgene expression using immunocytochemistry, enzymatic assays, and fluorescence‐activated cell sorting (FACS) analysis. Curr. Protoc. Neurosci. 45:4.23.1‐4.23.43. © 2008 by John Wiley & Sons, Inc.
Gene Expression Analysis of Neural Cells and Tissues Using DNA Microarrays
Authors: Karsten Stanislav L. , Kudo Lili C. , Geschwind Daniel H. 
Published: October 2008

AbstractDNA microarrays pose specific challenges to those studying the central and peripheral nervous systems. Probably the most important involve difficulty in obtaining appropriate tissue for study, as well as the problems posed by cellular heterogeneity. This unit describes advances in the available technologies and provides protocols for cDNA microarray hybridization, including the use of PCR amplicons. Protocols are also provided for the two major methods for limiting cellular heterogeneity by study of RNA from single cell populations in high‐throughput microarray studies, laser capture microdissection (LCM), and automated fluorescent cell sorting (FACS‐array). Curr. Protoc. Neurosci. 45:4.28.1‐4.28.38. © 2008 by John Wiley & Sons, Inc.
Animal Models of Obsessive‐Compulsive Disorder
Authors: Witkin Jeffrey M. 
Published: October 2008

AbstractObsessive‐compulsive disorder (OCD) occurs with high prevalence, and the drugs used to treat OCD are limited in efficacy and have side‐effect issues. The discovery of improved medicines for OCD has been hampered in part by the lack of predictive in vivo models. This unit provides a brief overview of two methods that might have such predictive utility. Marble burying and nestlet shredding are two behaviors that occur spontaneously with high frequency and repetitiveness in mice. These acute in vivo assays are relatively easy to conduct. Selective serotonin uptake inhibitors decrease these behaviors without producing motor side effects, as assessed by the behavior of walking on a rotating rod. In contrast, some other drugs (e.g., benzodiazepine anxiolytics) only affect marble burying and nestlet shredding at motor‐impairing doses. The present methods might therefore provide one piece of in vivo information for the discovery of novel chemical treatment solutions for the symptoms of OCD.Curr. Protoc. Neurosci. 45:9.30.1‐9.30.9. © 2008 by John Wiley & Sons, Inc.