bluuebunny/crossref_metadata_2025_split huggingface dataset:
Successful desensitization to horse antithymocyte globulin for aplastic anemia: two case reports and literature review
Authors: Yuyama Satoshi , Oura Mitsuaki , Isezaki Tatsuya , Ikeda Daisuke , Kitahara Kanayuki , Funakoshi Ryohkan , Matsue Kosei 
Published: February 2025

Abstract

Background
Horse antithymocyte globulin (hATG) is an important therapeutic option for aplastic anemia (AA). However, hATG carries the risk of fatal anaphylaxis, and skin tests are performed to identify high-risk patients. We report on the successful desensitization of two AA patients with positive skin tests to hATG.

Case presentation
Case 1: A 72-year-old man with a history of successful treatment with rabbit ATG was referred for pancytopenia. Neutrophil, reticulocyte, and platelet counts were 546 /µL, 32,000 /µL, and 19,000 /µL, despite the oral administration of eltrombopag and cyclosporine. Bone marrow biopsy showed hypocellularity, and he was diagnosed with relapsed severe AA. Case 2: A 69-year-old man was referred for anemia and thrombocytopenia, and diagnosed with non-severe AA. Neutrophil, reticulocyte, and platelet counts were 2,044 /µL, 23,000 /µL, and 37,000 /µL. Bone marrow biopsy revealed hypocellularity. Neither patient had a history of allergy, and the skin prick test (SPT) of hATG was negative, but the intradermal test (IDT) was positive. The result of the IDT in case 2 was reproducible. They received hATG desensitization under close monitoring of vital signs in our high-care unit. The protocol consisted of gradually increasing doses of hATG (four intradermal, two subcutaneous, and four intravenous (IV) push) and some premedications prior to administration of the full dose IV drip. They completed the course without developing any systemic allergic reactions.

Conclusions
Despite the risk of anaphylaxis, hATG desensitization can be beneficial in AA patients with a positive skin test, especially when no alternative is available or hATG is preferred.
Predictors of attendance at the first follow-up and poor visual outcome after paediatric cataract surgery in Kinshasa for the years 2001–2021
Authors: Schulz Helene , Rakuša Elena , Frech Stefanie , Stahnke Thomas , Kilangalanga Ngoy J. , Guthoff Rudolf F. , Doblhammer Gabriele 
Published: February 2025

Abstract

Background
About 90% of blind children come from low- and middle-income countries. The main cause of childhood blindness is cataract. Cataract surgery can improve vision, but regular follow-up is necessary. Low attendance at follow-up is a medical and statistical challenge, as missing information can lead to biased results. Two research questions arise: what social factors influence attendance at first follow-up? What social factors influence a poor outcome of visual acuity at first follow-up?

Methods
An observational cohort study was conducted, and the total base population was analysed. The study includes children who received cataract surgery at Saint Joseph Hospital (Kinshasa, Democratic Republic of the Congo) from 2001 to 2021. Cox regression was used to examine attendance at the first follow-up (n = 1100 operated eyes), ordinal logistic regression to analyse visual acuity at the first follow-up (n = 699 operated eyes), both clustered by patient identification number. Due to the high number of missing values, multiple imputation was performed as a sensitivity analysis.

Results
Female sex, young age, very good visual acuity after surgery, and disease in both eyes led to lower attendance at follow-up. Poor visual acuity outcome at follow-up was associated with female sex, young age, poor financial situation, blindness after surgery and nystagmus.

Conclusions
As regular follow-up is crucial for an improved visual acuity outcome, it is recommended that special attention needs to be paid to the groups identified in our analysis to better integrate them into follow-up. In particular, the higher risk of poor outcome in younger children is surprising and requires further analysis.
Cellular Uptake and Trafficking of Lipid Nanocarriers Using High-Resolution Electron Microscopy
Authors: Faber Thilo , Lamprecht Alf 
Published: February 2025

Abstract
Lipid based nanocarriers are a commonly used drug delivery system with cargos ranging from small molecules to complex RNA-based therapies. There are several hypotheses how such carriers can enter the cell, in which organelles they reside, and how they cross or escape the endo-lysosomal system. To provide additional insights, the cell-nanocarrier interplay was visualized exemplarily with lipid-based nanocarriers and macrophage-like cultured cells (J774A.1 cells) using high resolution electron microscopy. Nanocarrier uptake into J774A.1 cells was detectable after the first 15 min by intracellular accumulation of electron-dense material. These accumulations were identified as lysosomes and lipid droplets, indicating complete degradation and a subsequent formation of storage organelles as early as 15 min. Inhibition of lysosomal acid lipase did not block lipid droplet formation, but rather resulted in accumulation of lipid droplets within lysosomes. This suggests that other cellular lipases already degrade acylglycerols before they reach lysosomes. Chloroquine co-treatment allowed visualization of nanocarriers inside endosomal vesicles, multivesicular bodies, and lysosomes.

Graphical Abstract
“Sterile in Spanish Hands”
Authors: Mareite Thomas 
Published: February 2025

Abstract
This article examines schemes for reviving the French imperial presence in the Caribbean against the backdrop of the Haitian Revolution. It analyzes a series of memoranda sent to French ministries by imperial officials and former Saint-Domingue colonists that articulated ambitious visions of empire both before and after Haiti's independence. During a historical juncture that marked the apparent retreat of the French presence in the Western Hemisphere, proposals circulated in French ministries and colonial offices advocating the establishment of new diplomatic and territorial footholds across the Spanish Caribbean, especially in Cuba, with the intent of giving new life to French imperial projects in the Caribbean. Including both unsolicited and commissioned works, these proposals envisioned Spanish Caribbean colonies as new imperial possessions for the French empire that aimed at replicating Saint-Domingue on new lands or, alternatively, as launching pads for broader plans of reconquest of the lost “Pearl of the Antilles.” Key to these prospective schemes was the ubiquitous presence of a community of exiled French colonists across the Spanish Caribbean, especially in eastern Cuba, which underpinned visions of productive improvement under French rule and the foundation of new territorial footholds supporting renewed French imperial designs in the Western Hemisphere.
Hommes algériens, femmes françaises
Authors: André Marc 
Published: February 2025

Précis
A rebours de travaux en sciences humaines et sociales ayant figé les migrants algériens en France dans leur statut officiel de « célibataires », cet article montre combien les échanges étaient fréquents avec les femmes métropolitaines dans les années 1950–60. Il s'appuie sur des sources qui, bien que n'ayant aucunement pour objet les relations sentimentales ou sexuelles des migrants comme des métropolitaines, n'en révèlent pas moins la fréquence de ces relations : parce que les milliers de dossiers d'enquêtes policières centralisés par le ministère de l'Intérieur durant la guerre d'indépendance algérienne s'intéressent aux fréquentations et emplois du temps des victimes, suspects ou coupables, de nombreux couples mixtes apparaissent. Ces couples contractualisés ou non, légitimes ou non, durables ou non, façonnent une réalité historique autrement peu visible et permettent de se défaire des catégories figées par le pouvoir colonial au profit d'une microsociologie des relations dans un contexte particulier, celui de la guerre d'indépendance. Cet article permet d'approfondir nos connaissances sur une société française plurielle marquée par la colonisation, l'immigration et la guerre, comme sur les conséquences de la guerre dans l'intimité des individus. Il rééquilibre enfin les représentations en redonnant aux immigrés algériens et aux femmes françaises toute leur place dans l'histoire.
“Défendons Notre Liberté par la Force”
Authors: Azzarelli Andrea 
Published: February 2025

Abstract
At the beginning of the twentieth century, large parts of the world witnessed a wave of strikes. In response, groups of independent trade unionists, private industrial security forces, and associations of strikebreakers created new practices to defend social stability and private property. This article focuses on the strikebreaking associations active in France before World War I. It examines the nature of the nineteenth-century French state, describing the patterns of collaboration between authorities and strikebreakers. It concentrates on the actions of two Parisian groups: the Liberté du Travail, founded in 1908 by Jean Allembert, and the Bourse Libre du Travail de Paris, founded in 1911 by Pierre Lambert. Mainly present in the Parisian public works sector, these two groups were capable of violence and provided effective labor replacement. The article argues that French police forces were willing to cooperate with such violent private forces and shows that public authorities sought hegemony over violence rather than a complete monopoly.
The Colonial Enlightenment and Slavery in Eighteenth-Century Mauritius
Authors: La Hausse de Lalouvière Joseph 
Published: February 2025

Abstract
The fall of the Compagnie des Indes after the Seven Years’ War prompted a crown takeover of the Mascarene Islands in the Indian Ocean. The new royal administration in Ile de France (modern Mauritius) turned to natural and economic science to increase the island's productivity and improve the condition of enslaved people. However, a network of colonists and ex-Company men, represented by the Mauritian-born landholder Joseph-François Charpentier de Cossigny, embedded themselves in the apparatus of enlightened reforms. In the absence of an established plantation system on the island, they exploited the persistence of Company-style patrimonialism to obtain public subsidies for their investments in slavery. Cossigny framed the horticultural, commercial, ethnographic, and scientific research he conducted as public service. His critics denounced it as rent seeking. Lobbying for Mascarene slaveholders in Paris during the Revolution convinced Cossigny that the Enlightenment could be more than an extension of economic claims making; it could be mobilized to reinvent Atlantic slavery in the Indian Ocean. An Enlightenment born of colonialism on the periphery of the plantation complex thus flowed into an emerging antiabolitionist movement.
What makes a competent aquatic invader? Considering saline niches of invertebrates and ray-finned fishes
Authors: Freire Carolina A. 
Published: February 2025

ABSTRACT
Aquatic invasive species are of growing concern globally, especially in fresh water. The problem is intensified by climate change, which often causes salinization of coastal fresh waters. Animals deal with salinity through the function of osmoregulation, and osmoregulatory ability can be informative when considering invasive potential. A species is said to be ‘euryhaline’ if it can tolerate a wide range of salinities, either through osmoregulation (tightly controlling its extracellular fluid osmolality) or osmoconformation (matching the osmotic concentration of its internal fluids with that of the environment). Euryhaline animals display a large fundamental saline niche (FSN); i.e. a wide physiological tolerance of salinity change. However, the range of salinities of the habitats where a species actually occurs define its realized saline niche (RSN). Importantly, aquatic species living in stable habitats (i.e. those with little variation in salinity) will have a small RSN, but may have large FSNs, depending on their evolutionary history. Species with large FSNs are more likely to be successful invaders of new habitats with different salinities. Here, I propose the term ‘osmotic comfort’ as a concept that is associated with the FSN. The core of the FSN corresponds to ∼100% osmotic comfort, or ‘optimum salinity’, putatively meaning minimum stress. Physiological markers of osmotic comfort can provide raw data for mechanistic niche modelling in aquatic habitats. A species with a larger FSN is more likely to remain ‘osmotically comfortable’ in a different saline habitat, and is less likely to suffer local extinction in fresh waters, for example, that undergo salinization.
Risk of sarcopenia among older adults and associated factors in daily life
Authors: Pana Anastasia , Sourtzi Panayota , Kalokairinou Athina , Galanis Petros , Velonaki Venetia Sofia 
Published: February 2025

Background: Sarcopenia-associated lifestyle factors are not fully recognised. Community nurses could identify such factors and promote intervention strategies, mitigating the risk of sarcopenia. Aims: To investigate the health indicators and lifestyle factors that have an impact on increased sarcopenia risk among older adults in the community. Methods: A cross-sectional study was conducted with data collected using a structured questionnaire. The SARC-F questionnaire was used for the risk assessment of sarcopenia. The Barthel index, Fatigue Severity Scale, Visual Analogue Scale and Athens Insomnia Scale were used to assess functionality, fatigue and sleep. The duration of sleep was self-reported. Descriptive statistics and logistic regression were used for the data analysis. Findings: A total of 100 subjects (median age=72.50 years) were included in this pilot study. Among the participants, 19% were identified as being at risk for sarcopenia. Functionality, fatigue and sleep difficulties predicted the risk for sarcopenia. Conclusions: Community nurses could identify older adults at risk of sarcopenia by recognising the associated factors in everyday life. Implications for practice: Nurses in community settings could contribute to the prevention, early detection, slow progression or even potential reversal of sarcopenia by identifying, evaluating and addressing related factors to sarcopenia in the daily lives of community-dwelling older adults. Conducting routine screenings for muscle strength and function, promoting targeted exercise programmes and providing nutritional guidance to support muscle health can make a significant difference. Nurses and other healthcare professionals can collaborate to develop personalised intervention plans to provide comprehensive care to older adults for mobility and independence.
Caminem cap a una escola amb una mirada restaurativa
Authors: Cabau Pomar Rosanna , Vilà Geli Susanna , Román Romero Mònica 
Published: February 2025

Caminar cap a una escola restaurativa ha suposat tenir present el benestar emocional de tota la Comunitat Educativa. Cuidar-nos en les nostres relacions interpersonals i construir una xarxa de persones que conviuen creant vincles, ha esdevingut un dels pilars fonamentals de la nostra escola.
Quan parlem d’Enfocament Restauratiu Global (ERG) no parlem d’una metodologia, parlem de la transmissió de valors com el respecte, la inclusió, la responsabilitat i la cooperació.
Per treballar i aprofundir en aquests valors hem de desenvolupar en el nostre alumnat diferents capacitats bàsiques com són l’escolta activa i empàtica, la comunicació no violenta (CNV) i l’alfabetització de les emocions.
En definitiva, el nostre objectiu és aconseguir un infant crític, dialogant i responsable, que formi part d’una comunitat amable i que utilitzi una comunicació oberta i positiva.
Caregiver ECHO: A Model for Delivering Virtual Behavior Management Education to Families of Children With Neurodevelopmental Disorders
Authors: Nevill Rose E. , Lovette Gail E. , Bateman Katherine J. , Badgett Natalie M. , Lyons Genevieve R. , Fuhrmann Emily C. , Bohac Genevieve E. , Orlando Karen G. , Page Keith D. 
Published: February 2025

Abstract
Children with neurodevelopmental disorders (NDD) are at high risk of challenging behavior, yet families experience consistent barriers to affordable parent education in behavior management. This study tested the efficacy of a caregiver-focused Extensions of Community Health Outcomes (ECHO) program in delivering behavior management education and support to caregivers of children with NDD. A pre-post design was used to evaluate impact on 30 caregivers’ behavioral knowledge, self-efficacy in managing challenging behavior, empowerment, and negative emotional reactions to challenging behavior. Participation resulted in significant improvements across outcomes and high satisfaction. The Caregiver ECHO model offers advantages in that it emphasizes peer learning, active problem solving, and community building as core components of its approach while using low-cost methodologies.
Longitudinally Predicting Behavioral Challenges From Executive Functioning in Youth With Down Syndrome
Authors: Soltani Amanallah , Fidler Deborah J. , Patel Lina , Voth Kellie , Esbensen Anna J. 
Published: February 2025

Abstract
This study explored how caregiver-reported executive functioning domains, assessed by the BRIEF2 at baseline, predicted behavioral challenges reported by caregivers using the CBCL six months later. The sample included 94 youth with Down syndrome, aged 6 to 18 years. Results of hierarchical regression analyses revealed that, after controlling for the effect of IQ, working memory significantly predicted inattentive behaviors, inhibition significantly predicted rule-breaking behaviors, and both inhibition and emotional control significantly predicted aggressive and externalizing behaviors. After controlling for baseline behaviors, only working memory persisted as a significant predictor of inattentive behaviors measured six months later. The findings are discussed by referring to the relevant theories and research and providing clinical implications and recommendations for further studies.
LLIN Evaluation in Uganda Project (LLINEUP2) – Effect of long-lasting insecticidal nets (LLINs) treated with pyrethroid plus pyriproxyfen vs LLINs treated with pyrethroid plus piperonyl butoxide in Uganda: A cluster-randomised trial
Authors: Gonahasa Samuel , Namuganga Jane Frances , Nassali Martha J. , Maiteki‑Sebuguzi Catherine , Nabende Isaiah , Epstein Adrienne , Snyman Katherine , Nankabirwa Joaniter I. , Opigo Jimmy , Donnelly Martin J. , Dorsey Grant , Kamya Moses R. , Staedke Sarah G. 
Published: February 2025

Long-lasting insecticidal nets (LLINs) are the cornerstone of malaria control, but their effectiveness is threatened by pyrethroid resistance. We embedded a pragmatic, cluster-randomised trial into Uganda’s national LLIN distribution campaign in 2020–2021, comparing pyrethroid-piperonyl butoxide (PBO) LLINs to pyrethroid-pyriproxyfen LLINs. Target communities surrounding public health facilities (clusters, n=64), covering 32 districts were included. Clusters were randomised 1:1 in blocks of two by district to receive: (1) pyrethroid-PBO LLINs (PermaNet 3.0, n=32) or (2) pyrethroid-pyriproxyfen LLINs (Royal Guard, n=32). LLINs were delivered from 7 November 2020 to 26 March 2021. Malaria surveillance data were collected from health facilities from 1 November 2019 until 31 March 2023. Cluster-level estimates of malaria incidence in residents of all ages (primary outcome) were generated from enhanced health facility surveillance data. Cross-sectional community surveys were conducted in randomly selected households (at least 50 per cluster) at 12-months (24 November 2021 to 1 April 2022) and 24-months (23 November 2022 to 21 March 2023) post-LLIN distribution. Overall, 186,364 clinical malaria episodes were diagnosed in cluster residents during 398,931 person-years of follow-up. At 24-months, malaria incidence was lower than baseline in both arms (pyrethroid-PBO: 465 vs 676 episodes per 1000 person-years; pyrethroid-pyriproxyfen: 469 vs 674 episodes per 1000 person-years); but there was no evidence of a difference between the arms (incidence rate ratio 1.06, 95% confidence interval [CI] 0.91–1.22, p=0.47). Two years post-distribution, ownership of at least one LLIN for every two household residents was low in both arms (41.1% pyrethroid-PBO vs 38.6% pyrethroid-pyriproxyfen). Parasite prevalence in children aged 2-10 years was no different between the arms in either survey (24-months: 26.1% pyrethroid-PBO; 29.5% pyrethroid-pyriproxyfen; odds ratio 1.29 [95% CI: 0.81–2.05], p=0.29). The effectiveness of pyrethroid-PBO LLINs and pyrethroid-pyriproxyfen LLINs was no different in Uganda, but two years after mass distribution, LLIN coverage was inadequate.
Trial registration: NCT04566510. Registered 28 September 2020, https://clinicaltrials.gov/ct2/show/NCT04566510
Using health belief model to assess the determinants of HIV/AIDS prevention behavior among university students in Central, Tanzania: A cross-sectional study
Authors: Seif Saidi J. , Oguma Erick Donard , Joho Angelina A 
Published: February 2025

The adolescent and youth population is at high risk of contracting HIV infection. Little is known in Tanzania regarding the application of Health Belief Model (HBM) in identifying the factors that influence HIV prevention behaviors within this group. This study aims to use the Health Belief Model to assess the determinants of HIV/AIDS prevention behavior among University students in central Tanzania. The analytical cross-sectional study design was conducted among undergraduate students at the University of Dodoma and St. John University in Tanzania, from 15th June 2024 to 15th July 2024. The multiple sampling techniques were employed to select 310 study participants. A structured questionnaire adapted from previous studies was used to collect data from study participants. The determinants of HIV/AIDS prevention behaviors were analyzed using bivariable and multivariable binary logistic regression models. The majority of study respondents 248 (80%) had adequate knowledge of HIV/AIDS prevention behaviors. Most of respondents had high perceived barrier 175 (56.5%) and high perceived benefit 194 (62.6%) toward HIV prevention behavior. More than half of the study respondents had negative attitude 172 (55.5%) and low level of engagement in HIV/AIDS prevention behavior 173 (55.8%). The University students with high perceived barriers (aOR = 0.58, 95% CI: 0.350–0.966; p = 0.036) and negative attitudes (aOR = 0.60, 95% CI: 0.362–0.995; p = 0.048) were less likely to engage in HIV/AIDS prevention behavior practice. This study revealed that more than half of university students were poorly engaged in HIV/AIDS prevention behavior practice. This low level of engagement was mostly influenced by high perceived barriers and negative attitudes toward HIV prevention behavior. Putting more efforts into initiatives to educate university students about HIV prevention practices, will help to maximize their awareness and encourage them to participate in HIV/AIDS prevention behavior.