bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevention of intravascular metastases of B16 murine melanoma: Adjuvant chemotherapy with actinomycin D
Authors: Richie Jerome P. 
Published: February 2007

AbstractActinomycin D was tested in an experimental preparation to determine its efficacy in the prevention of intravenous metastases. B16 melanoma cells were injected intravenously in syngeneic C57/BL6 mice. Two cell lines of the tumor, designated F1 and F10, with widely different metastatic potentials, were maintained in tissue culture and utilized for evaluation of pulmonary metastases. When actinomycin D was given intraperitoneally at doses of 0.05 and 0.075 mg/kg for 5 days, the number of pulmonary metastases was significantly decreased (P<.001) in both the F1 and F10 cell lines. Although reduction did occur with a single dose, maximum reduction of pulmonary metastases was effected with a dose schedule adminstered over 5 days. Evaluation of a group of mice 2 and 3 wk after injection of tumor cells revealed that the effects of actinomycin D were not secondary to delay in tumor growth but did represent highly significant differences in numbers of metastatic lesions.It is concluded that in this experimental preparation actinomycin D, given in an adjuvant setting, can significantly reduce the number of pulmonary metastases. This study may have bearing on the design of adjuvant intraoperative and perioperative chemotherapy in order to destroy circulating tumor cells.
Treatment of asymptomatic metastatic cancer to the liver from primary colon and rectal cancer by the intraarterial administration of chemotherapy and radioactive isotopes
Authors: Ariel Irving M. , Padula Guido 
Published: February 2007

AbstractForty patients with asymptomatic metastatic cancer to the liver discovered at the time of laparotomy were treated by combined intrahepatic arterial chemotherapy and internal irradiation in the form of 90Yttrium microspheres. One group of 25 patients were treated by a catheter inserted at the time of operation and received 100 mCi; of 90Yttrium microspheres and 5‐fluorouracil on a continuing basis. They survived an average of 26 mo (varying from 9 to 60 mo). The second series of 15 patients referred after surgery were treated by the percutaneous insertion of the catheter into the hepatic artery and received a bolus of combined chemotherapy consisting of PlatinolTM, Methotrexate, and 5‐fluorouracil. They survived an average of 31 mo, which varied from 12 to 60 mo. The dose of 100 mCi of 90Yttrium was well tolerated by the liver. Prospective studies are in progress, limiting the treatment to the internal irradiation to determine its precise role in the overall treatment of metastatic cancer to the liver.
Partial protection of the gastric toxicity of regional 5‐fluorouracil infusion by thymidine and cimetidine
Authors: Al‐Jurf Adel S. 
Published: February 2007

AbstractGastric ulceration resulted from regional (infusion) chemotherapy when high doses of 5‐fluorouracil were accidently infused into the stomach during hepatic artery infusions. A method for reproduction of those ulcers was established by gastric artery infusions. A trial to protect against such development with thymidine produced only partial protection. Measurement of gastric acid output in animals receiving one dose of 5‐fluorouracil showed no change in basal acid secretion but a significant decrease in histamine‐stimulated output. Partial protection from ulcer development was also accomplished with cimetidine alone.
Steroid receptors in tumors of nerve sheath origin
Authors: Chaudhuri Prabir K. , Walker Michael J. , Das Gupta Tapas K. , Beattie Craig W. 
Published: February 2007

AbstractThe present study dearly demonstrates that neurofibromas and neurofibrosarcomas are devoid of cytosol receptor for steroid. These observations are in sharp contrast to the significant incidence of receptors in soft tissue and osseous sarcomas and raise doubts that steroids exert a direct effect on the growth of these tumors.
Common‐sense untoward factors in lung cancer resection
Authors: Valente Maurizio , Pastorino Ugo , Cataldo Ignazio , Piva Luigi , Muscolino Giuseppe , Ravasi Gianni 
Published: February 2007

AbstractFour common‐sense untoward factors (age over 60, pneumonectomy, microresidual disease, and postoperative empyema) were retrospectively evaluated in a consecutive series of 199 surgically apparently complete non‐oat cell lung cancer resections. By single‐factor analysis all factors showed a lower survival that was contingent for microresidual disease and age over 60. For stage I tumors the negative impact on survival was significant for all except empyema, and for stage II and III tumors only for empyema. Without confounding factors, microresidual disease and age over 60 were negative prognostic factors only for distant mortality, empyema a negative prognostic factor only for early mortality, and pneumonectomy a probable negative prognostic factor for both early and distant mortality. It is concluded that the scientific method used confirmed the prognostic assessment of common sense for these four factors.
In vivo holography of vocal cords
Authors: Raviv G. , Marhic M. E. , Scanlon E. F. , Sener S. F. , Epstein M. 
Published: February 2007

AbstractA new holographic technique is utilized to obtain in vivo three dimensional photographic records. The development of a holographic endoscopic camera (endoholoscope or holocamera) provides a unique method of diagnosis of internal organs and tissues. A hologram of the larynx of an anesthetized dog shows details which could not be observed by indirect laryngoscopy.
In vivo delayed hypersensitivity reactions to partially purified human melanoma antigens
Authors: Sutherland Carl M. , Leong Stanley P. L. , Cooperband Sidney R. , Deckers Peter J. , Hornung Maria O. , Krementz Edward T. 
Published: February 2007

AbstractSera from patients receiving autologous cell immunization were shown to contain antibody specific for melanoma cells by immunofluorescence, microcomplement fixation, and mixed hemadsorption. These hyperimmune specific sera were used to define antigens shed into tissue culture media from human malignant melanoma cells. When supernatants from cultured melanoma cells were passed over a Sephadex G‐200 column, melanoma‐antigens were found in Peak 2. The active fraction was further purified by carboxymethylcellulose ion exchanger and found in the 0.4 M NaCl gradient. This fraction has been tested in four immunized patients and in one nonimmunized melanoma patient. All five patients developed lymphocytic vasculitis compatible with delayed hypersensitivity reaction. These antigens should be of benefit in studying delayed hypersensitivity in melanoma patients and as potential agents for specific immunotherapy.
Mallory‐weiss syndrome secondary to cis‐platinum chemotherapy: An unusual complication
Authors: Lubicz Stephane , Shafir Michail , Diamond Sharon , Monosan Robert , Cohen Carmel 
Published: February 2007

AbstractThe Mallory‐Weiss syndrome is a relatively infrequent cause of digestive tract bleeding and most cases have been described in alcoholics. Nonoperative management is frequently successful. We present here a case of sudden onset of wretching and vomiting after IV infusion of cis‐platinum for recurrent carcinoma of the uterine cervix in which the patient had profuse hematemesis secondary to three posterior gastroesophageal tears requiring operative intervention after failure of nonsurgical management. This is an unusual complication of antineoplastic chemotherapy and its prevention is emphasized in this paper.
The importance of treatment sequence in advanced and metastatic carcinoma of the breast
Authors: Awrich Alan E. , Peetz Michael E. , Moseley H. Stephens , Keenan Edward , Davenport Charlene E. , Fletcher William S. 
Published: February 2007

AbstractFrom 1965 to the present, 287 patients with advanced and metastatic carcinoma of the breast have been treated according to a uniform philosophy of sequential therapy. Surgical castration was the initial procedure for premenopausal women and for postmenopausal women with clinical or laboratory evidence of endocrine responsive tumors. Tumor progression following castration was treated with major endocrine ablation, either adrenalectomy or hypophysectomy. Patients who relapsed following major ablation were treated with antiestrogen therapy as it became available. Nonresponders to major ablation and patients relapsing after antiestrogen therapy were treated with combination chemotherapy including cytoxan, methotrexate, 5‐fluorouracil, and vincristine followed by adriamycin alone or in combination. Progression following chemotherapy was treated with additive hormonal therapy. Radiation therapy was used throughout for the control of localized disease, usually following complete hormonal ablation, except in cases of brain and spinal metastatic disease. The median survival for the entire group was 40.5 months from the onset of metastatic disease. Patients who responded to both oophorectomy and major ablation had a median survival of 61 months, which compares favorably to survival of 14 to 22 months reported in major combination chemotherapy trials. Survival following this method of sequential therapy is superior to other plans of management.
Estrogen receptor status in inflammatory breast carcinoma
Authors: Harvey Harold A. , Lipton Allan , Lawrence Bellarmine V. , White Deborah S. , Wells Samuel A. , Blumenschein George , Lee David 
Published: February 2007

AbstractSixteen women with a clinical diagnosis of inflammatory breast carcinoma had estrogen receptor analysis performed. Eleven of 16 were premenopausal. Median age of all patients was 46 years. All patients had estrogen receptor (ER) assay by either dextran charcoal method or by sucrose gradient method. Five patients were ER+ (⩾ fmol/mg cytosol protein) and 11 were ER‐, with almost no binding at all. Response to therapy for metastatic disease using either hormones or chemotherapy was disappointing.
Hormone receptor levels related to histological parameters of tumor‐host relationships in female breast carcinoma
Authors: Syrjänen Kari J. , Kosma Veli‐Matti 
Published: February 2007

AbstractA series of 115 female breast carcinomas was studied with special emphasis on the relationships between the hormone receptor (ER and PR) levels and the histological parameters reflecting tumor‐host reactivity. Carcinomas were classified according to their nuclear grade (NG) and the stromal host reactions; perivenous lymphocyte infiltration (PVI), lymphocyte (LI), plasma cell (PCI), and mast cell infiltration (MI) were assessed. NG did correlate directly with the ER positivity, but not with the absolute ER values. LI and PCI, but not MI and PVI, showed an inverse relation to the ER values, but not to those of PR. ER and to lesser extent the PR values were higher in postmenopausal than in premenopausal women. The findings are discussed in the light of tumor‐host relationships, and conclusion is drawn that the receptor determinations used in connection with the histological evaluation of these parameters (NG especially) are of definite benefit in dividing the breast cancer patients into groups of different expectancy of the future outcome of their disease.
Growth of squamous cell esophageal carcinoma observed by serial esophagographies
Authors: Takagi Iwao , Karasawa Kazuo 
Published: February 2007

AbstractEarly superficial‐type squamous cell esophageal carcinoma is seldom detected by esophagography. Review of the records at the Aichi Cancer Center Hospital revealed seven cases in which serial esophagograms were available to observe the growth pattern and speed of squamous cell esophageal carcinoma from its early superficial to advanced invasive stages. The esophageal carcinomas were found to grow very rapidly longitudinally as well as horizontally compared to gastric carcinomas. The longitudinal growth of the lesion appears to be constant and can be expressed as a linear function of time. Importance of early detection should be stressed in order to improve the poor cure rate of this fast‐growing tumor.
Effects of diethylstilbestrol diphosphate on serum and tissue ribonuclease levels in prostatic carcinoma
Authors: Erkan Ilhan , Ciliv Gonenc , Remzi Dogan 
Published: February 2007

AbstractThirty‐six patients with prostatic carcinoma and benign prostatic hyperplasia (BPH) were studied. Transurethral resection (TUR) was performed in all, and serum and tissue ribonuclease (RNase) levels were determined with the spectrophotometric method using yeast RNA as the substrate. In patients with untreated prostatic carcinoma, statistically significant increased RNase levels were found in serum and tissue. Treatment with di‐ethylstilbestrol diphosphate (DESDP) led to a decrease in RNase levels. In the same patients RNase serum levels after DESDP treatments also showed a parallel decrease with serum prostatic acid phosphatase (sPAP) levels. We have concluded that the serum RNase measurement may be useful for TNM classification and immunostaging.
Excretion of tumor‐associated antigen(s) in the urine of patients with colon carcinoma
Authors: Finck Sanford J. , Gupta Rishab K. , Giuliano Armando E. , Morton Donald L. 
Published: February 2007

AbstractUrine samples collected from patients with colon carcinoma and from normal donors were tested for antigenic activity by the microcomplement fixation assay. When autologous serum was used as the antibody source, 65.4% (17/26) of the urine samples from patients with colon carcinoma were positive for antigen as opposed to only 10% (2/20) from normal volunteers. Absorption of a representative serum with cultured colon cancer cells completely removed reactivity against its autologous urine. Using this serum to screen urine from colon carcinoma patients, antigenic activity was found in 71.4% (30/46) of the samples; however, only 10% (2/20) of the urine samples from apparently healthy volunteers were positive. Analysis of urine samples collected from three patients before and after resection of their primary colon carcinoma and from nine patients undergoing hyperthermia for liver metastases revealed that two of the patients who had curative surgical procedures had marked decreases in urinary antigen levels by the second postoperative day, while the third patient whose disease was unresectable had no significant decrease. Seven of nine patients with metastatic disease had a greater than four fold increase in antigen activity after hyperthermia and chemotherapy. These results suggest that tumor‐associated antigens were excreted into urine, possibly the result of treatment‐caused tumor necrosis. Therefore, assessment of tumor‐associated antigen(s) in the urine of patients with colon carcinoma may serve as a marker for response to treatment of this disease.
The influence of pancreatic hormones and diabetogenic procedures on erythropoietin production
Authors: Naughton Brian A. , Naughton Gail K. , Liu Philip , Zuckerman Gary B. , Gordon Albert S. 
Published: February 2007

AbstractThe influence of the pancreas on renal and extrarenal erythropoietin (Ep) production and on the elaboration of the hepatic erythropoietic factor (HEF) was studied in these experiments. Insulin was found to elevate Ep levels in the anephric hypoxic rat when compared to controls, whereas glucagon treatment augmented the hepatic Ep response to hypoxia in the sub‐totally hepatectomized (hepx) animal while lowering it in the renal intact rat. Production of experimental diabetes either through chemical induction by alloxan or following pancreatectomy diminished the Ep response in all groups tested. Treatment with antiglucagon caused an elevation in the Ep response to hypoxia in the intact rat but lowered Ep levels in the hepx animal. In addition, glucagon and a synthetic hepatotrophic agent (L‐histidyl L‐lysine acetate) stimulated HEF production in the hepx rat, although none of the agents tested were capable of enhancing HEF levels in the intact rat.
Evaluation of tumor aggressiveness in breast carcinoma according to a scoring method
Authors: Wernicke Mario , Podesta Augusto 
Published: February 2007

AbstractA scoring system was used to classify 310 patients with breast carcinoma. Tumors were divided and scored according to their architectural patterns and histological features of known prognostic significance such as tumor volume, nuclear grade, mitosis, etc. According to the scoring value, tumors were classified as aggressive (A), moderately aggressive (M), and low aggressive (L). Results showed a higher rate of metastasis in patients with A tumors (72%) and M tumors (63%) when compared with L tumors (22%). There were 175 patients with axillary lymph node metastasis. Of these, 101 had A tumors, 91 had recurrences (90%), and 81 died (80%); of the 56 patients with M tumors, 26 had recurrences (46%) and 9 died (16%) (P < 0.001). None of the 18 cases classified as L recurred (P < 0.001). There were 135 patients with no nodal metastasis: 39 had A tumors (21 recurrences [54%] and 19 deaths [49%]) and 96 had M and L tumors (1 recurrence [1%] and no deaths) (P < 0.001).
Low‐grade keratinizing squamous carcinoma recurrent in same extremity three times in nine years via local embolic interstitial dermal metastasis
Authors: Burkett Frank E. , Jernstrom Paul H. 
Published: February 2007

AbstractA case of low‐grade, keratinizing squamous carcinoma recurring at progressively distal levels in the same extremity four times in nine years in a 59‐year‐old Caucasian woman is presented. It is theorized that this represents a progression of the same tumor via embolic interstitial spread.
Transitional cell carcinoma of the anterior urethra
Authors: Harty James I. , Mojsejenko Irene K. 
Published: February 2007

AbstractWe report a case of transitional cell carcinoma of the anterior male urethra. Unlike squamous cell carcinoma of the anterior urethra, which usually requires partial penectomy, transitional cell carinoma of this location can be managed with conservative local resection and preservation of the penis. Possible explanations for the origin of this lesion are discussed.
Long‐term intraarterial chemotherapy infusion of ambulatory head and neck cancer patients
Authors: Baker Shan R. , Wheeler Richard H. 
Published: February 2007

AbstractThe complications of percutaneous intraarterial infusion chemotherapy of the head‐and‐neck‐cancer patient has dampened enthusiasm for this approach. A totally implantable infusion pump system circumvents many of these complications and will in the long term enhance the opportunity to expand upon the advantanges of infusion chemotherapy for the benefit of all cancer patients.
Teratoma of thyroid gland in infancy: Review of the literature and two case reports
Authors: Fisher John E. , Cooney Donald R. , Voorhess Mary L. , Jewett Theodore C. 
Published: February 2007

AbstractTeratomas of the cervical area are relatively rare tumors — only 132 cases have been reported. This paper adds two more cases to the literature and reviews the important clinical aspects of the disease. This tumor commonly presents in early infancy with increasing respiratory distress; polyhydramnios is commonly associated with tumors greater than 10 cm in diameter. They are always benign in infants and are believed to arise from the thyroid gland. Prompt surgical removal is mandatory. Thyroid function studies should be initiated preoperatively, if feasible, and definitely postoperatively to avoid the possible complication of hypothyroidism in the young infant.
Adjuvant chemotherapy (CMF) for breast carcinoma: Hematological side effects
Authors: Lee Yeu‐tsu N.(Margaret) 
Published: February 2007

AbstractSeventy‐five patients accepted postmastectomy adjuvant CMF chemotherapy for stage II and III carcinoma of the breast. All patients, irrespective of age, were started on the same drug dosages. About 42% of the patients had leukopenia during the first two cycles; this rate was similar for patients who dropped out of the program early and those who stayed on for six or more months. Patients who developed leukopenia early are more likely to receive less than 65% of mean total CMF dosages (MTD). Otherwise, 30% of patients that never had leukopenia or had leukopenia that appeared late received more than 85% of the prescribed CMF. In our series, postmenopausal patients did not have more problem with leukopenia than premenopausal patients (thrombocytopenia occurred rarely in both groups). Among the 58 patients who had CMF for 6 months or longer, 79% had less than 85% MTD of CMF. The dosages had to be reduced for drug‐related and other reasons, and leukopenia only accounted for 22% of patients who had reduced CMF dosages.
Primary adenocarcinoma of the appendix: A report of two cases
Authors: Lee Shiong S. , Song Ki T. 
Published: February 2007

AbstractPrimary adenocarcinoma of the appendix is rare; approximately 200 cases have been reported. Preoperative diagnosis is extremely difficult. We report two cases with two distinctive histologic patterns of adenocarcinoma resulting in different outcomes. The classification and treatment of primary epithelial malignant tumors of the appendix are also discussed.
Selection of gastrectomy for adenocarcinomas arising in the gastric fundus
Authors: Papachristou Dimitrios N. , Fortner Joseph G. 
Published: February 2007

AbstractA retrospective study involving 174 patients with adenocarcinoma of the gastric fundus treated with proximal subtotal (PS), extended proximal subtotal (EPS), total (T), and extended total (ET) gastrectomy showed that 1)there were no statistically significant differences in operative mortality between the four gastrectomy types; 2)ET was associated with a significantly lower incidence of local recurrence than T (P < 0.05) and PS (P < 0.001); 3)ET resulted in a significantly higher survival rate than PS or T (P < 0.01) when the three procedures were applied in patients who had TNM stage I and II tumors; 4)patients with stage III and IV tumors did poorly regardless of gastrectomy type. The study implies that intraoperative tumor staging might identify stage I and II patients who benefit the most from radical surgery and those with stage III and IV tumors who should receive palliative surgery.
Erythrocyte survival studies in a rat myelogenous leukemia
Authors: Derelanko Michael J. , Meagher Richard C. , Lobue Joseph , Khouri Janine A. , Gordon Albert S. 
Published: February 2007

AbstractTo determine the extent intrinsic erythrocyte defects and/or extrinsic factors were involved in anemia of rats bearing Shay chloroleukemia (SCL), survival of 3H‐DFP labeled erythrocytes was studied in leukemic and non‐leukemic hosts. Red blood cells labeled before induction of leukemia, were rapidly lost from the peripheral circulation of SCL rats in terminal stages of disease. However, labeled erythrocytes from terminal SCL animals displayed normal lifespans when transfused into nonleukemic controls. Thus the anemia of this leukemia probably resulted from extrinsic factors associated with the leukemic process. Hemorrhage appeared to be primarily responsible for the anemia of this disease.
Use of serum copper/zinc ratio in patients with large bowel cancer
Authors: Gray Bruce N. , Walker Colin , Barnard R. 
Published: February 2007

AbstractThe serum copper/zinc ratio was measured in 44 patients bearing primary large bowel malignancies. Measurements were repeated following removal of the primary tumour and again at the time of development of clinical evidence of cancer recurrence in order to evaluate the clinical value of the ratio to accurately reflect the presence or absence of malignancy. Estimation of serum copper levels do reflect the presence of malignancy, but the copper/zinc ratio is of no added value. As other acute phase proteins have been shown to be superior to serum copper as markers for monitoring of cancer patients, it is concluded that in patients with large bowel cancer, monitoring with serum copper/zinc is of no clinical value.