bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-term outcome of 9G MRI-guided vacuum-assisted breast biopsy: results of 293 single-center procedures and underestimation rate of high-risk lesions over 12 years
Authors: Rescinito Giuseppe , Brunetti Nicole , Garlaschi Alessandro , Tosto Simona , Gristina Licia , Conti Benedetta , Pieroni Diletta , Calabrese Massimo , Tagliafico Alberto Stefano 
Published: March 2024

Abstract
Purpose
Breast magnetic resonance imaging (MRI) can detect some malignant lesions that are not visible on mammography (MX) or ultrasound (US). If a targeted, second-look fails, MRI-guided breast biopsy is the only available tool to obtain a tissue sample and pathological proof of these “MRI-only lesions”. The aim of this study is to report the performance and underestimation rate of 9G MRI-guided vacuum-assisted breast biopsy (VABB) over 12 years at a single center.

Material and methods
All 9G MRI-VABB procedures performed from January 2010 to December 2021 were retrospectively reviewed. Two MRI scanners (1.5 T and 3 T) were used with the same image resolution and contrast media. All suspicious lesions detected only by breast MRI underwent biopsy. Reference standard was histological diagnosis or at least 1-year negative follow-up. All malignant and atypical lesions underwent surgery, which was used as the reference standard.

Results
A total of 293 biopsies were retrospectively reviewed. Histopathological VABB results revealed 142/293 (48.4%) benign lesions, 77/293 (26.2%) high-risk lesions, and 74/293 (25.2%) malignant lesions. No significant complications were observed. Surgical pathology results allowed for the reclassification of n = 7/48 B3b lesions: n = 4 were ductal carcinoma in situ, while n = 3 presented invasive features at surgical histology (2 IDC; 1 ILC). B3b underestimation occurred overall in 14.6% of B3 cases. Breast follow-up was achieved for all benign VABB results, and only one false-negative case was observed.

Conclusion
Our results confirm that 1.5 T and 3 T MRI-guided VABB is an accurate and safe procedure for histopathologic final diagnosis of MRI-only lesions. Critical issues remain the potential high-risk underestimation rate of B3b VABB results and management of follow-up of benign lesions.
Quantum Technologies: a Hermeneutic Technology Assessment Approach
Authors: Possati Luca M. 
Published: March 2024

AbstractThis paper develops a hermeneutic technology assessment of quantum technologies. It offers a “vision assessment” of quantum technologies that can eventually lead to socio-ethical analysis. Section 2 describes this methodological approach and in particular the concept of the hermeneutic circle applied to technology. Section 3 gives a generic overview of quantum technologies and their impacts. Sections 4 and 5 apply the hermeneutic technology assessment approach to the study of quantum technologies. Section 5 proposes distinguishing three levels in the analysis of the creation and communication of social meanings to quantum technologies: (a) fictions, (b) popularization, and (c) scientific journalism. Section 6 analyzes the results and defines some lines of action to increase social acceptance and trust in quantum technologies. The aim of this paper is to contribute to the debate on quantum technologies by enhancing the reflection on them and their potential, as well as illustrating the complexity of technological innovation and the need to shape it.
Capital risk, fiscal policy, and the distribution of wealth
Authors: Modena Andrea , Regis Luca 
Published: March 2024

AbstractWe develop a dynamic model economy where self-employed entrepreneurs allocate their net worth to their firm capital and risk-less government bonds, facing borrowing constraints, uninsurable labour endowment and capital depreciation risk. We derive a numerical approximation of the model’s equilibrium and compare it with a benchmark economy with no capital risk. Unlike labour endowment risk, capital risk reduces aggregate capital accumulation and wages and generates a positive risk premium. Low- (high-) net-worth entrepreneurs, whose consumption depends primarily on labour (financial) income, hold higher (lower) capital risk exposure. These patterns exacerbate inequality by increasing the share of financially constrained individuals and fattening the tails of the net worth distribution. Fiscal policy affects these outcomes by redistributing resources and affecting the risk premium. Capital tax cuts benefit more low- or high-net-worth entrepreneurs, depending on whether taxes on bonds or labour income finance them.
Bioactive compounds of fresh tea shoots plucked in different seasons: optimization of extraction of polyphenols
Authors: Chebbi Hind , Turkmen Erol Nihal , Incedayi Bige , Sari Ferda 
Published: March 2024

AbstractIn this study, the effects of harvest year and period on the total polyphenol (TP), radical scavenging activity (RSA), total flavonoid (TF) and ascorbic acid (AA) contents of fresh tea leaves were investigated. Extraction of polyphenols from the tea leaf was optimized using the response surface methodology (RSM). The effect of the independent variables ((solvent concentration, extraction time and solid to solvent (S/S) ratio)) on TP and RSA was studied using Box-Behnken design (BBD). The results showed that extraction parameters selected were significant in the extraction procedure regarding TP and RSA (p < 0.05). The optimum extraction conditions were obtained as 1/60.86 of S/S ratio, 84.65% of ethanol concentration and the extraction time of 50 min. As a result of the extraction of tea leaves under optimum conditions, the TP, RSA and TF contents of the leaves harvested in September in 2020 were found to be higher. In addition, the individual phenolic compounds of these leaves were analyzed by high performance liquid chromatography (HPLC) and epigallocatechin gallate (EGCG) was detected the most (57.52 mg/g DM). After in-vitro digestion of the same samples, TP and RSA values ​​were significantly decreased, mostly at intestinal stage (p < 0.05), and the bioaccessibility of the polyphenols was determined as 48.98%. As a result of AA analysis by HPLC of the, the highest contents for 2019 and 2020 were observed in the leaves harvested in May (41.92 mg/100 g DM) and those in July (38.55 mg/100 g DM), respectively.
Is There a Mitochondrial Protection via Remote Ischemic Conditioning in Settings of Anticancer Therapy Cardiotoxicity?
Authors: Kleinbongard Petra , Andreadou Ioanna 
Published: March 2024

Abstract
Purpose of Review
To provide an overview of (a) protective effects on mitochondria induced by remote ischemic conditioning (RIC) and (b) mitochondrial damage caused by anticancer therapy. We then discuss the available results of studies on mitochondrial protection via RIC in anticancer therapy-induced cardiotoxicity.

Recent Findings
In three experimental studies in healthy mice and pigs, there was a RIC-mediated protection against anthracycline-induced cardiotoxicity and there was some evidence of improved mitochondrial function with RIC. The RIC-mediated protection was not confirmed in the two available studies in cancer patients. In adult cancer patients, RIC was associated with an adverse outcome. There are no data on mitochondrial function in cancer patients.

Summary
Studies in tumor-bearing animals are needed to determine whether RIC does not interfere with the anticancer properties of the drugs and whether RIC actually improves mitochondrial function, ultimately resulting in improved cardiac function.
Comparison of consistency in centiloid scale among different analytical methods in amyloid PET: the CapAIBL, VIZCalc, and Amyquant methods
Authors: Shang Cong , Sakurai Keita , Nihashi Takashi , Arahata Yutaka , Takeda Akinori , Ishii Kazunari , Ishii Kenji , Matsuda Hiroshi , Ito Kengo , Kato Takashi , Toyama Hiroshi , Nakamura Akinori ,   BATON Study Group
Published: March 2024

Abstract
Objective
The Centiloid (CL) scale is a standardized measure for quantifying amyloid deposition in amyloid positron emission tomography (PET) imaging. We aimed to assess the agreement among 3 CL calculation methods: CapAIBL, VIZCalc, and Amyquant.

Methods
This study included 192 participants (mean age: 71.5 years, range: 50–87 years), comprising 55 with Alzheimer’s disease, 65 with mild cognitive impairment, 13 with non-Alzheimer's dementia, and 59 cognitively normal participants. All the participants were assessed using the three CL calculation methods. Spearman’s rank correlation, linear regression, Friedman tests, Wilcoxon signed-rank tests, and Bland–Altman analysis were employed to assess data correlations, linear associations, method differences, and systematic bias, respectively.

Results
Strong correlations (rho = 0.99, p < .001) were observed among the CL values calculated using the three methods. Scatter plots and regression lines visually confirmed these strong correlations and met the validation criteria. Despite the robust correlations, a significant difference in CL value between CapAIBL and Amyquant was observed (36.1 ± 39.7 vs. 34.9 ± 39.4; p < .001). In contrast, no significant differences were found between CapAIBL and VIZCalc or between VIZCalc and Amyquant. The Bland–Altman analysis showed no observable systematic bias between the methods.

Conclusions
The study demonstrated strong agreement among the three methods for calculating CL values. Despite minor variations in the absolute values of the Centiloid scores obtained using these methods, the overall agreement suggests that they are interchangeable.
Game-theoretic analysis of competition between access service providers utilizing a Nash genetic algorithm
Authors: Kamalakis Thomas , Dede Georgia , Michalakelis Christos , Nikolaidou Mara 
Published: March 2024

AbstractFiber-to-the-home (FTTH) technology is a promising solution for providing advanced service delivery to end-users, but its implementation requires substantial capital expenditures. To minimize investment risks and aid decision-making for access service providers, we propose a game theoretic framework based on a modified Nash genetic algorithm. We illustrate how this framework can be applied to analyze the competition between access providers offering a flat-rate FTTH service on multiple geographical areas. Each provider determines its price for all areas simultaneously and decides whether to invest on a particular area depending on the anticipated revenues. Two distinct demand models are adopted to describe different types of consumer behavior. A solution engine, based on a modified mixed-variable Nash genetic algorithm is implemented under an open-source license. The significance and practical implications of the equilibrium points obtained for both single and multiple area games are discussed. The proposed framework and the solution engine developed, aid both providers and regulatory bodies to analyze competitive environments. They can also be used to implement decision support tools for similar problems as well. The paper concludes by pointing out further research directions in this context.
Multianalytical approach to the exceptional Late Roman shipwreck of Ses Fontanelles (Mallorca, Balearic Islands, Spain)
Authors: Cau-Ontiveros Miguel Ángel , Bernal-Casasola Darío , Pecci Alessandra , Fantuzzi Leandro , Picornell-Gelabert Llorenç , Valenzuela Oliver Alejandro , Retamosa José Alberto , Portillo-Sotelo José Luis , Cardell Perelló Jaume , Munar Llabrés Sebastià , de Juan Fuertes Carlos , García Riaza Enrique 
Published: March 2024

AbstractThe paper presents the results of an interim analytical approach to the Late Roman shipwreck of Ses Fontanelles recently found in the island of Mallorca (Balearic Islands, Spain). The excellent state of preservation of the hull and the cargo, including amphorae with painted inscriptions (tituli picti), and its location in shallow waters offshore of one of the main touristic beaches of the island makes this a unique finding in the Mediterranean. A first season of excavations and study of the cargo triggered an analytical approach to solve some of the problems pose by archaeological research, mainly related to the possible origin of the vessel. The analytical strategy combines petrographic analysis for the study of the provenance of the amphorae, archaeozoology and residue analysis to identify their content, and analysis of the wood and plant remains to understand the use of vegetal resources in shipbuilding and in the stow of the cargo. The results of the combination of the petrographic analysis, the study of the ichthyofauna and the organic residue analysis suggest that the boat probably departed from the area of Cartagena in the southeastern part of the Iberian Peninsula, carrying a cargo of fish sauce (liquaminis flos), oil, and wine (probably also some olives preserved in grape derivatives), transported in three main types of amphorae. The analysis of the wood shows, as known in Roman shipbuilding, a clear selection of forest resources. The shipbuilders used pine for longitudinal parts of the hull, while for the small pieces related to the assemblage system (pegged, mortise and tenons) and subjected to a great stress they selected harder woods mainly Cupressaceae, Olea europaea, and Laurus nobilis. In addition, the study reveals that mainly branches of Vitis vinifera, but also other herbaceous plants were used as dunnage protecting the cargo during the journey. The results help to shed some light into different aspects of this unique vessel sunk in Mallorcan waters and contributes to show the benefit of applying archaeological sciences in maritime archaeology.
Trade dynamics between Carthage and Iberia at the end of the 3rd century BC: analytical characterisation of central mediterranean amphorae from Qart-Hadasht (Cartagena, Spain)
Authors: Cutillas-Victoria Benjamín , Camino Miguel Martín , Asensio Sebastián F. Ramallo 
Published: March 2024

AbstractThe founding of Qart-Hadasht, or ‘New Carthage’, in 228/227 BC reaffirmed the Carthaginian presence on the Iberian Peninsula. The city would serve as its main political base and military port in the Western Mediterranean before being lost to Rome in the Second Punic War. Although the conquest was led on the ground by the Barcid family, the town’s flourishing also led to an increase in the metropolis’s economic and commercial activities. In this study, a total of 37 amphorae of Central Mediterranean typology and located in different Punic contexts of the town were analysed using X-ray fluorescence (XRF), thermogravimetry (TG), X-ray diffraction (XRD) and thin-section petrography (OM). The analyses reveal that a significant number of them originated in North Africa, mainly in the area of Tunisia, though some originated from other production centres on the island of Sicily and probably Algeria. The results also confirm the existence of shared amphora types produced in different Punic production areas and workshops. Thus, the central argument here is that the arrival of containers from such diverse provenances allows us to identify the economic opportunity that this foundation represented for the metropolis as a whole and to explore how this new trade relationship was structured.
Circular RNA circCHSY1 silencing inhibits the malignant progression of esophageal squamous cell carcinoma
Authors: He Haiquan , Chen Ying , Liang Hanping , Che Weibi , Chen Huilong , Chen Ying , Peng Fengyuan , Wu Bomeng 
Published: March 2024

Abstract
Background
CircRNAs play a crucial role in the regulation of various cancers. This study aims to investigate the involvement of circCHSY1 in the development of esophageal squamous cell carcinoma (ESCC).

Methods
RNA levels were quantified using qRT-PCR, and protein levels were measured by western blot. The stability of circCHSY1 was analyzed using RNase R. The functional effect of circCHSY1 on cell behavior was evaluated by CCK-8, EdU, flow cytometry, transwell, tube formation, and xenograft tumor model assays. The associations among circCHSY1, miR-1229-3p, and Tectonic-1 (TCTN1) were certified by bioinformatics analysis, dual-luciferase reporter assay, and RNA pull-down assay.

Results
CircCHSY1 was up-regulated in both ESCC tissues and cell lines in comparison with the control groups. Knockdown of circCHSY1 inhibited the proliferation, migration, invasion, and tube formation and promoted apoptosis of ESCC cells. Mechanistically, circCHSY1 targeted miR-1229-3p, which was downregulated in ESCC tissues and cells. Inhibition of miR-1229-3p attenuated the effects mediated by circCHSY1 suppression. Besides, miR-1229-3p bound to TCTN1, and TCTN1 overexpression restored miR-1229-3p-induced effects in ESCC cells. Animal experiments revealed that circCHSY1 silencing suppressed tumor tumorigenesis in vivo.

Conclusion
CircCHSY1 contributed to ESCC cell malignancy, and the underlying mechanism involved the circCHSY1/miR-1229-3p/TCTN1 axis, providing potential therapeutic targets for ESCC.
Mechanism of regulation of KIF23 on endometrial cancer cell growth and apoptosis
Authors: Zhuang Ruiying , Liu Haiyan 
Published: March 2024

Abstract
Objective
The global incidence of endometrial cancer, a malignant tumor in females, is on the rise. It is one of the most common gynecological cancers. Early-stage endometrial cancers can often be treated successfully with uterine extirpation. However, those diagnosed at a later stage have a poor prognosis and encounter treatment challenges. Therefore, additional research is necessary to develop primary prevention strategies for high-risk women and improve survival rates among patients with endometrial cancer. Hence, gene therapy targeting KIF23 shows promise as an advanced strategy for the treatment of endometrial cancer.

Methods
Immunohistochemistry, Western blotting, and PCR were used to examine the expression of KIF23 and its associated pathway factors in endometrial cancer tissue (specifically Ishikawa and SNGM cells, respectively). We investigated the functional roles of KIF23 using CCK-8, colony-forming proliferation assays, Transwell migration assays, and xenotransplantation in mice.

Results
Immunohistochemistry analysis showed variations in the expression levels of KIF23 between endometrial cancer tissue and normal endometrium tissue. KIF23 downregulated BAX and caspase-3 protein expression while upregulating BCL-2 protein expression. Additionally, knocking out KIF23 inhibits endometrial cancer cell proliferation and migration while promoting cell death. Mechanistically, our study provides evidence that KIF23 promotes endometrial cancer cell proliferation by activating the ERK and AKT/PI3K pathways, while simultaneously inhibiting programmed cell death in endometrial cancer.

Conclusion
Our study provides evidence to support the inhibition of endometrial cancer by KIF23 knockdown. This offers valuable insights for future research on potential therapeutic strategies for this type of cancer.

Graphical Abstract
Exclusion and invented water scarcity: a historical perspective from colonialism to apartheid in South Africa
Authors: Kaziboni Anthony 
Published: March 2024

AbstractThis paper examines the dynamics of water governance in South Africa during the colonial and apartheid periods, focusing on the socio-economic and political invented water scarcity experienced by black communities. By exploring historical policies and legislation, such as the Irrigation and Conservation of Water Act No. 8 of 1912, the Riparian Rights principle, and the Water Act of 1956, this study sheds light on black people’s systemic exclusion and marginalisation from accessing water resources. The analysis reveals how water governance practices were utilised as instruments of power and control, disproportionately favouring European settlers and reinforcing racial inequalities. Implementing discriminatory policies, forming reserves and forcing removals to Bantustans, establishing segregated water supply systems, and discriminatory practices in farms, mines, and urban townships, resulted in invented water scarcity for black communities. The deliberate exclusion of black communities from equitable water access created systemic disadvantages, impacting health, livelihoods, and socio-economic development. This paper argues that invented water scarcity was integral to colonial and apartheid strategies, further entrenching power imbalances and exacerbating socio-economic disparities.
Forecast accuracy and physics sensitivity in high-resolution simulations of precipitation events in summer 2022 by the Korean Integrated Model
Authors: Lee Eun-Hee , Cho Sujeong , Cho Keon-Hee , Han Ji-Young , Lee Youngsu , Kim Junghan 
Published: March 2024

AbstractThe precipitation prediction of the Korean Integrated Model (KIM) is evaluated over South Korea for the summer season of July–August 2022, and key factors for accurate predictions are examined using various approaches, including case studies under distinct synoptic patterns and physics sensitivity experiments. In this study, a five-day prediction experiment was conducted using the latest version of KIM in a near real-time full cycle configuration with 8-km grid spacing, while additional case simulations and prediction tests were conducted on low-resolution or cold-run testbeds. For verification, a newly designed synoptic pattern verification was introduced to assist to the conventional dichotomous verification for daily precipitation. It was found that heavy rainfall events over South Korea are determined by two dominant patterns: frontal and cyclonic. KIM can successfully discriminate between synoptic patterns with a detection rate of approximately 85% for these two types within a short-range prediction. However, it is evident that the precise prediction of precipitation requires an accurate location of the precipitation system within a specified timeframe, wherein KIM shows weakness in delaying the movement of extratropical cyclones with forecast lead times. The significance of moist physics is also highlighted by sensitivity experiments that control convective trigger conditions. This demonstrates that large-scale precipitation from a microphysics scheme must be enhanced to properly represent the strong development of inland rain systems over South Korea, which are highly sensitive to convective precipitation activity in the numerical model, especially in upwind ocean regions.