bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anatomizing online collaborative inquiry using directional epistemic network analysis and trajectory tracking
Authors: Ba Shen , Hu Xiao , Stein David , Liu Qingtang 
Published: February 2024

AbstractAccurate assessment and effective feedback are crucial for cultivating learners' abilities of collaborative problem‐solving and critical thinking in online inquiry‐based discussions. Based on quantitative content analysis (QCA), there has been a methodological evolvement from descriptive statistics to sequential mining and to network analysis for mining coded discourse data. Epistemic network analysis (ENA) has recently gained increasing recognition for modelling and visualizing the temporal characteristics of online discussions. However, due to methodological restraints, some valuable information regarding online discussion dynamics remains unexplained, including the directionality of connections between theoretical indicators and the trajectory of thinking development. Guided by the community of inquiry (CoI) model, this study extended generic ENA by incorporating directional connections and stanza‐based trajectory tracking. By examining the proposed extensions with discussion data of an online learning course, this study first verified that the extensions are comparable with QCA, indicating acceptable assessment validity. Then, the directional ENA revealed that two‐way connections between CoI indicators could vary over time and across groups, reflecting different discussion strategies. Furthermore, trajectory tracking effectively detected and visualized the fine‐grained progression of thinking. At the end, we summarize several research and practical implications of the ENA extensions for assessing the learning process.Practitioner notesWhat is already known about this topic

Assessment and feedback are crucial for cultivating collaborative problem‐solving and critical thinking in online inquiry‐based discussions.
Cognitive presence is an important construct describing the progression of thinking in online inquiry‐based discussions.
Epistemic network analysis is gaining increasing recognition for modelling the temporal characteristics of online inquiries.
What this paper adds

Directional connections between discourses can reflect different online discussion strategies of groups and individuals.
A pair of connected discourses coded with the community of inquiry model can have different meanings depending on their temporal order.
A trajectory tracking approach can uncover the fine‐grained progression of thinking in online inquiry‐based discussions.
Implications for practice and/or policy

Besides the occurrences of individual discourses, examining the meanings of directional co‐occurrences of discourses in online discussions is worthwhile.
Groups and individuals can employ different discussion strategies and follow diverse paths to thought development.
Developmental assessment is crucial for understanding how participants achieve specific outcomes and providing adaptive feedback.
Outcome of malignant lymphoma in Ukraine. Analysis of 563 cases registered in the Ukrainian Lymphoma Registry in 2019–2021
Authors: Stepanishyna Yana , Manni Martina , Civallero Monica , Shokun Nazar , Skrypets Tetiana , Burtna Alevtyna , Shapovalenko Natalia , Tytorenko Iryna , Aleksyk Olena , Pastushenko Yan , Gubareva Hanna , Moiseienko Kateryna , Kadnikova Tetyana , Rudyuk Timur , Filonenko Kateryna , Martynchyk Arina , Novosad Olga , Galli Giulia R. , Kryachok Irina , Federico Massimo 
Published: February 2024

SummaryWe report the outcome of 563 cases of newly diagnosed lymphoma registered in 2019–2021, including 176 cases (31.2%) of Hodgkin lymphoma (HL), 130 (23.1%) of diffuse large B‐cell lymphoma (DLBCL), 28 (5%) of follicular lymphoma (FL), 16 (2.9%) of mantle cell lymphoma (MCL) and 20 (3.5%) of peripheral T‐cell lymphoma (PTCL). After a median follow‐up of 30.1 months (95% CI: 28.8–31.3), the 3‐year overall survival rates were 95%, 83%, 86%, 100%, 61% and 42% for HL, DLBCL, CLL, FL, MCL and PTCL respectively. These data offer valuable information on the curability of lymphoma patients in Ukraine, in a real‐world setting.
Geometry and evolution of polygonal fault systems under a regionally anisotropic stress field: Insights from 3D seismic analysis of the Qiongdongnan Basin, NW South China Sea
Authors: Hu Shouxiang , Rotevatn Atle , Jackson Christopher , Li Wei , Wu Xiaochuan 
Published: February 2024

AbstractPolygonal fault systems (PFS) are developed in many sedimentary basins, and their formation, growth, and ultimate geometry have been widely studied. The geometry and growth of PFS forming under the influence of regionally anisotropic stresses, however, are poorly understood, despite the fact these structures may serve as key paleo‐stress indicators that can help reconstruct the tectonic and stress history of their host basins. We here use high‐quality 3D seismic reflection data and quantitative fault analysis to determine the geometry and evolution of a PFS in the Qiongdongnan Basin (NW South China Sea), and its possible relationship with the geological and stress history of the basin. The PFS is dominated by two intersecting NNW‐to‐N‐ and E‐striking fault sets, which initiated in the Early Miocene. The dominant fault strike at the structural level at which the faults nucleated and where strain is greatest (i.e., Lower Miocene) is close to NW–SE. However, at the top and bottom of the PFS tier faults strike NNW–SSE, thereby defining a very slight vertical, clockwise rotation of strike. Based on the observation that the host rock is flat‐lying, it is unlikely that basin‐tilting perturbed (i.e., δ2 ≠ δ3) the otherwise radially isotropic stress field that typically characterize PFS. Likewise, diapirs that punctuate the host rock and that are spatially related to the PFS appear not to control fault geometry. We instead infer that the PFS geometry reflects a combination of local isotropic and regional, extension‐related tectonics stress affecting the Qiongdongnan Basin during the Early Oligocene to Middle Miocene. Regional studies suggest that during this time, extensional stresses in eastern Qiongdongnan Basin rotated clockwise from roughly NNW to N; we noticed the rotation of strike of the PFS, within which the vertical change in fault strike being relatively minor. Our study determines the timing of polygonal fault growth within the Qiongdongnan Basin and the associated geometry, highlighting the key role played by regional and local stresses.
Constructing child participation in early years classrooms: An exploration from Wales
Authors: Waters‐Davies Jane , Murphy Alison , Chicken Sarah , Tyrie Jacky , Clement Jennifer 
Published: February 2024

AbstractThis paper addresses the research problem that arises from evidence that, despite supportive policy contexts, enactment of pedagogies that attend to young children's participation rights in classroom settings is highly variable. We report our exploration of the ways in which the child, and child participation are constructed in early education settings in Wales, where legislation and policy around children's rights has been a key feature of the Welsh Government agenda post‐devolution. Data were gathered via a qualitative online bilingual (English and Welsh) survey offered via email to teachers of children aged 3–7 in Wales. The overarching research question of the project was: How do teachers of children 3–7 years understand and enact the notion of participation as it relates to the children they teach? Data analysis focused on research participants' apparent constructions of the children they teach and their capabilities, and unpacked the ways in which these constructions relate to the reported opportunities for participation. The discussion is informed by the notion of the threshold concept, described by Meyer & Land as akin to a portal that opens new and previously inaccessible ways of thinking. We consider the extent to which the conceptual construction of the capable child maybe a threshold concept in shaping the realisation of children's participation rights in educative contexts.
Narrow band imaging reveals field cancerisation undetected by conventional white light: Optical diagnosis versus histopathology
Authors: Westra Jeroen M. , Zwakenberg Manon A. , Halmos Gyorgy B. , van der Laan Bernard F. A. M. , van der Vegt Bert , Plaat Boudewijn E. C. 
Published: February 2024

AbstractObjectiveTo assess whether narrow band imaging (NBI) detects fields of cancerisation around suspicious lesions in the upper aerodigestive tract, which were undetected by white light imaging (WLI).MethodsIn 96 patients with laryngeal and pharyngeal lesions suspicious for malignancy, 206 biopsies were taken during laryngoscopy: 96 biopsies of suspicious lesions detected by both WLI and NBI (WLI+/NBI+), 60 biopsies adjacent mucosa only suspicious with NBI (WLI‐/NBI+), and 46 biopsies of NBI and WLI unsuspicious mucosa (WLI‐/NBI‐) as negative controls. Optical diagnosis according to the Ni‐classification was compared with histopathology.ResultsSigns of (pre)malignancy were found in 88% of WLI+/NBI+ biopsies, 32% of WLI‐/NBI+ biopsies and 0% in WLI‐/NBI‐ (p < .001). In 58% of the WLI‐/NBI+ mucosa any form of dysplasia or carcinoma was detected.ConclusionThe use of additional NBI led to the detection of (pre)malignancy in 32% of the cases, that would have otherwise remained undetected with WLI alone. This highlights the potential of NBI as a valuable adjunct to WLI in the identification of suspicious lesions in the upper aerodigestive tract.
Treatment of childhood obesity based on the reduction of ultra‐processed foods plus energy restriction: A randomised controlled trial based on the Brazilian guidelines
Authors: Brandão Joana Maia , Sichieri Rosely , Paravidino Vitor Barreto , Ribas Simone Augusta , Cunha Diana Barbosa 
Published: February 2024

SummaryReducing ultra‐processed foods (UPF) improves diet quality and may curb energy consumption. This study aimed to compare an intervention based on the reduction of UPF, according to the Dietary Guideline for the Brazilian Population (DGBP), with and without advice on energy intake. A parallel and randomised controlled trial was carried out with children with obesity from 7 to 12 years old. Both control (CG) and intervention groups (IG) participated monthly in 6 standardised educational activities based on the 10 steps of the DGBP. An individualised food plan was also provided to the IG. The rate of change for body mass index (BMI), waist circumference, body weight, and UPF consumption were investigated based on mixed‐effect models. At the end of the study, the BMI declined in the IG (Δ = −0.27 kg/m2) compared to the CG (Δ = + 0.53 kg/m2) (p = .0002). Both groups showed a decline in grams of UPF until the fourth month and a gradual increase in the following months. Combining the qualitative approach of the DGBP with counselling on energy restriction through the diet plan proved to be effective in reducing childhood obesity. Clinical Trial Registration: This trial is registered at the Brazilian Registry of Clinical Trials (REBEC), under the RBR‐3st5sn registry, available at http://www.ensaiosclinicos.gov.br/rg/RBR-3st5sn/. The datasets generated by the current study are not publicly available but are available from the corresponding author on reasonable request.
AAV‐mediated Gpm6b expression supports hair cell reprogramming
Authors: Sun Qiuhan , Zhang Liyan , Chen Tian , Li Nianci , Tan Fangzhi , Gu Xingliang , Zhou Yinyi , Zhang Ziyu , Lu Yicheng , Lu Jie , Qian Xiaoyun , Guan Bing , Qi Jieyu , Ye Fanglei , Chai Renjie 
Published: February 2024

AbstractIrreversible damage to hair cells (HCs) in the cochlea leads to hearing loss. Cochlear supporting cells (SCs) in the murine cochlea have the potential to differentiate into HCs. Neuron membrane glycoprotein M6B (Gpm6b) as a four‐transmembrane protein is a potential regulator of HC regeneration according to our previous research. In this study, we found that AAV‐ie‐mediated Gpm6b overexpression promoted SC‐derived organoid expansion. Enhanced Gpm6b prevented the normal decrease in SC plasticity as the cochlea develops by supporting cells re‐entry cell cycle and facilitating the SC‐to‐HC transformation. Also, overexpression of Gpm6b in the organ of Corti through the round window membrane injection facilitated the trans‐differentiation of Lgr5+ SCs into HCs. In conclusion, our results suggest that Gpm6b overexpression promotes HC regeneration and highlights a promising target for hearing repair using the inner ear stem cells combined with AAV.
Acute changes in cardiac dimensions, function, and longitudinal mechanics in healthy individuals with and without high‐altitude induced pulmonary hypertension at 4559 m
Authors: Mereles Derliz , Rudolph Jens , Greiner Sebastian , Aurich Matthias , Frey Norbert , Katus Hugo A. , Bärtsch Peter , Dehnert Christoph 
Published: February 2024

AbstractBackgroundHigh‐altitude pulmonary hypertension (HAPH) has a prevalence of approximately 10%. Changes in cardiac morphology and function at high altitude, compared to a population that does not develop HAPH are scarce.MethodsFour hundred twenty‐one subjects were screened in a hypoxic chamber inspiring a FiO2 = 12% for 2 h. In 33 subjects an exaggerated increase in systolic pulmonary artery pressure (sPAP) could be confirmed in two independent measurements. Twenty nine of these, and further 24 matched subjects without sPAP increase were examined at 4559 m by Doppler echocardiography including global longitudinal strain (GLS).ResultsSPAP increase was higher in HAPH subjects (∆ = 10.2 vs. ∆ = 32.0 mm Hg, p < .001). LV eccentricity index (∆ = .15 vs. ∆ = .31, p = .009) increased more in HAPH. D‐shaped LV (0 [0%] vs. 30 [93.8%], p = .00001) could be observed only in the HAPH group, and only in those with a sPAP ≥50 mm Hg. LV‐EF (∆ = 4.5 vs. ∆ = 6.7%, p = .24) increased in both groups. LV‐GLS (∆ = 1.2 vs. ∆ = 1.1 –%, p = .60) increased slightly. RV end‐diastolic (∆ = 2.20 vs. ∆ = 2.7 cm2, p = .36) and end‐systolic area (∆ = 2.1 vs. ∆ = 2.7 cm2, p = .39), as well as RA end‐systolic area index (∆ = −.9 vs. ∆ = .3 cm2/m2, p = .01) increased, RV‐FAC (∆ = −2.9 vs. ∆ = −4.7%, p = .43) decreased, this was more pronounced in HAPH, RV‐GLS (∆ = 1.6 vs. ∆ = −.7 –%, p = .17) showed marginal changes.ConclusionsLV and LA dimensions decrease and left ventricular function increases at high‐altitude in subjects with and without HAPH. RV and RA dimensions increase, and RV longitudinal strain increases or remains unchanged in subjects with HAPH. Changes are negligible in those without HAPH.
Plant canopies promote climatic disequilibrium in Mediterranean recruit communities
Authors: Perez‐Navarro Maria A. , Lloret Francisco , Molina‐Venegas Rafael , Alcántara Julio M. , Verdú Miguel 
Published: February 2024

AbstractCurrent rates of climate change are exceeding the capacity of many plant species to track climate, thus leading communities to be in disequilibrium with climatic conditions. Plant canopies can contribute to this disequilibrium by buffering macro‐climatic conditions and sheltering poorly adapted species to the oncoming climate, particularly in their recruitment stages. Here we analyse differences in climatic disequilibrium between understorey and open ground woody plant recruits in 28 localities, covering more than 100,000 m2, across an elevation range embedding temperature and aridity gradients in the southern Iberian Peninsula. This study demonstrates higher climatic disequilibrium under canopies compared with open ground, supporting that plant canopies would affect future community climatic lags by allowing the recruitment of less arid‐adapted species in warm and dry conditions, but also it endorse that canopies could favour warm‐adapted species in extremely cold environments as mountain tops, thus pre‐adapting communities living in these habitats to climate change.
Self‐transcendent leadership: A meta‐perspective
Authors: Theissen Maximilian H. , Theissen Hubertus H. , Gümüsay Ali A. 
Published: February 2024

AbstractSelf‐transcendence as a concept is increasingly found in leadership literature—yet in diverse ways. It is this diversity that serves as the motivation for the current article in which we develop a comprehensive and coherent conceptualization of self‐transcendence for leadership research. We demonstrate that self‐transcendence is the cognitive orientation of accepting something other than one's self to be of highest worth. We show that this something, which is greater than the self, may take four different forms: other people, social collectives, moral principles and ideals, or metaphysical beings. We contribute to leadership research by linking each greater something to one theory: servant, transformational, moral, and spiritual leadership. Our conceptualization of self‐transcendence allows us to integrate different leadership theories into a meta‐perspective of self‐transcendent leadership. We conclude with implications for leadership research as well as practice.
Defining benchmark outcomes for mesial temporal lobe epilepsy surgery: A global multicenter analysis of 1119 cases
Authors: Drexler Richard , Ricklefs Franz L. , Ben‐Haim Sharona , Rada Anna , Wörmann Friedrich , Cloppenborg Thomas , Bien Christian G. , Simon Matthias , Kalbhenn Thilo , Colon Albert , Rijkers Kim , Schijns Olaf , Borger Valeri , Surges Rainer , Vatter Hartmut , Rizzi Michele , de Curtis Marco , Didato Giuseppe , Castelli Nicoló , Carpentier Alexandre , Mathon Bertrand , Yasuda Clarissa Lin , Cendes Fernando , Chandra Poodipedi Sarat , Tripathi Manjari , Clusmann Hans , Delev Daniel , Guenot Marc , Haegelen Claire , Catenoix Hélène , Lang Johannes , Hamer Hajo , Brandner Sebastian , Walther Katrin , Hauptmann Jason S. , Jeffree Rosalind L. , Kegele Josua , Weinbrenner Eliane , Naros Georgios , Velz Julia , Krayenbühl Niklaus , Onken Julia , Schneider Ulf C. , Holtkamp Martin , Rössler Karl , Spyrantis Andrea , Strzelczyk Adam , Rosenow Felix , Stodieck Stefan , Alonso‐Vanegas Mario A. , Wellmer Jörg , Wehner Tim , Dührsen Lasse , Gempt Jens , Sauvigny Thomas 
Published: February 2024

AbstractObjectiveBenchmarking has been proposed to reflect surgical quality and represents the highest standard reference values for desirable results. We sought to determine benchmark outcomes in patients after surgery for drug‐resistant mesial temporal lobe epilepsy (MTLE).MethodsThis retrospective multicenter study included patients who underwent MTLE surgery at 19 expert centers on five continents. Benchmarks were defined for 15 endpoints covering surgery and epilepsy outcome at discharge, 1 year after surgery, and the last available follow‐up. Patients were risk‐stratified by applying outcome‐relevant comorbidities, and benchmarks were calculated for low‐risk (“benchmark”) cases. Respective measures were derived from the median value at each center, and the 75th percentile was considered the benchmark cutoff.ResultsA total of 1119 patients with a mean age (range) of 36.7 (1–74) years and a male‐to‐female ratio of 1:1.1 were included. Most patients (59.2%) underwent anterior temporal lobe resection with amygdalohippocampectomy. The overall rate of complications or neurological deficits was 14.4%, with no in‐hospital death. After risk stratification, 377 (33.7%) benchmark cases of 1119 patients were identified, representing 13.6%–72.9% of cases per center and leaving 742 patients in the high‐risk cohort. Benchmark cutoffs for any complication, clinically apparent stroke, and reoperation rate at discharge were ≤24.6%, ≤.5%, and ≤3.9%, respectively. A favorable seizure outcome (defined as International League Against Epilepsy class I and II) was reached in 83.6% at 1 year and 79.0% at the last follow‐up in benchmark cases, leading to benchmark cutoffs of ≥75.2% (1‐year follow‐up) and ≥69.5% (mean follow‐up of 39.0 months).SignificanceThis study presents internationally applicable benchmark outcomes for the efficacy and safety of MTLE surgery. It may allow for comparison between centers, patient registries, and novel surgical and interventional techniques.
Therapeutic drug monitoring in pregnancy: Levetiracetam
Authors: Fallik Noam , Trakhtenbroit Ilia , Fahoum Firas , Goldstein Lilach 
Published: February 2024

AbstractObjectiveLevetiracetam (LEV) is an antiseizure medication that is mainly excreted by the kidneys. Due to its low teratogenic risk, LEV is frequently prescribed for women with epilepsy (WWE). Physiological changes during gestation affect the pharmacokinetic characteristics of LEV. The goal of our study was to characterize the changes in LEV clearance during pregnancy and the postpartum period, to better plan an LEV dosing paradigm for pregnant women.MethodsThis retrospective observational study incorporated a cohort of women who were followed up at the epilepsy in pregnancy clinic at Tel Aviv Sourasky Medical Center during the years 2020–2023. Individualized target concentrations of LEV and an empirical postpartum taper were used for seizure control and to reduce toxicity likelihood. Patient visits took place every 1–2 months and included a review of medication dosage, trough LEV blood levels, week of gestation and LEV dose at the time of level measurement, and seizure diaries. Total LEV concentration/dose was calculated based on LEV levels and dose as an estimation of LEV clearance.ResultsA total of 263 samples were collected from 38 pregnant patients. We observed a decrease in LEV concentration/dose (C/D) as the pregnancy progressed, followed by an abrupt postpartum increase. Compared to the 3rd trimester, the most significant C/D decrease was observed at the 1st trimester (slope = .85), with no significant change in the 2nd trimester (slope = .11). A significant increase in C/D occurred postpartum (slope = 5.23). LEV dose was gradually increased by 75% during pregnancy compared to preconception. Average serum levels (μg/mL) decreased during pregnancy. During the postpartum period, serum levels increased, whereas the LEV dose was decreased by 24%, compared to the 3rd trimester.SignificanceLEV serum level monitoring is essential for WWE prior to and during pregnancy as well as postpartum. Our data contribute to determining a rational treatment and dosing paradigm for LEV use during both pregnancy and the postpartum period.