bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perfectionism, Feelings of Not Mattering, and Suicide Ideation: An Integrated Test of the Perfectionism Social Disconnection Model and the Existential Model of Perfectionism
Authors: Etherson Marianne E. , Smith Martin M. , Hill Andrew P. , Sherry Simon B. , Curran Thomas , Flett Gordon L. , Hewitt Paul L. 
Published: March 2024

The Perfectionism Social Disconnection Model (PSDM) and the Existential Model of Perfectionism and Depressive Symptoms (EMPDS) are promising models of perfectionism and psychopathology. However, research examining suicide ideation within the PSDM is scarce, and no research has examined suicide ideation as an outcome in the EMPDS. Moreover, tests of the PSDM and EMPDS have been conducted separately and most research has examined the PSDM and EMPDS using cross-sectional or two-wave longitudinal designs, which do not provide a satisfactory test of mediation. In the current study, we addressed these limitations by testing whether perfectionism confers vulnerability to suicide ideation via feelings of mattering and anti-mattering (from the PSDM) and via difficulty accepting the past (from the EMPDS) in a three-wave longitudinal design in two independent samples of undergraduate students and community adults. Participants completed measures on three occasions over 6 weeks. Findings revealed that socially prescribed perfectionism indirectly predicted suicide ideation via difficulty accepting the past in both samples. In addition, in the undergraduate sample only, socially prescribed perfectionism indirectly predicted higher suicide ideation via anti-mattering, and self-oriented perfectionism indirectly predicted higher suicide ideation via mattering. Based on our findings, we advocate for future research to include suicide ideation in the PSDM and EMPDS, to integrate explanatory models, and to examine a mattering-specific EMPDS.
Effects of Tai-Chi on Quality of Life in People With Neurodegenerative Diseases. A systematic Review of Randomised Clinical Trials
Authors: Navas-Otero Alba , Pineda-Nogueras Alicia , Ortiz-Rubio Araceli , Calvache Mateo Andrés , Torres-Sánchez Irene , Carmen Valenza Marie , Granados-Santiago María 
Published: March 2024

Objective This systematic review aimed to evaluate the effects of Tai Chi on the health-related quality of life (HRQoL) of people with neurodegenerative diseases. Data Source This review followed the guidelines of the updated PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) 2020. A systematic search in five electronic databases (Medline via PubMed, Web of Science, Scopus, PEDro, and OTseeker) was performed. Study Inclusion and Exclusion Criteria Randomized control trials (RCTs) examining Tai Chi interventions to improve HRQoL in patients with neurodegenerative diseases published through March 2023 were included. Data Extraction Data were extracted from each study by two independent researchers into a data extraction form based on the Cochrane recommendations. Methodological quality and risk of bias were assessed. Data Synthesis A meta-analysis was performed using Review Manager 5.3 software. Results Of the 439 records that were screened, eight RCTs met the eligibility criteria. They assessed cognitive decline (n = 2) or Parkinson’s disease (n = 6). RCT comparison groups included active interventions or usual care. The duration of Tai Chi therapy ranged from 8 to 24 weeks. A sensitivity analysis using a fixed effect model indicated that Tai Chi therapy significantly increased HRQoL [ P < 001, SMD (95% CI) = .41 [.21, .60], I2 = 4%]. Conclusion Tai Chi can effectively improve the HRQoL of people with neurodegenerative diseases, but the heterogeneity across intervention was relatively high. Further studies are needed as research into the benefits of Tai Chi in neurodegenerative disease rehabilitation is still limited.
Energy loss mechanism of a full tubular pump under reverse power generation conditions using entropy production theory
Authors: Shi Lijian , Chen Yiyu , Yu Xianlei , Han Yi , Chai Yao , Xue Muzi 
Published: March 2024

This paper investigates the energy dissipation mechanism of the internal flow field of the full tubular pump during reverse power generation and pump conditions, utilizing CFD and model test methods to research the device’s hydraulic characteristics, internal flow field and entropy production. The results indicate that the reverse power generation and pump conditions’ performance curves have opposite trends. Under PRPG conditions, the flow uniformity and weighted average angle of the impeller inlet flow field are smaller and the inlet flow field is poor. The stator-rotor gap flow under PRPG conditions increases with the increase in total flow, the gap flow under the design flow is 2.88 L/s, and the torque is 7.35 N·m. Under the PRPG condition, the turbulent and wall entropy production ratio increases gradually with the flow increase. Under the design flow rate, the entropy production rate of the impeller is 55.07%, and the entropy production rate of the impeller is the largest among the components under different flow rates. The entropy production of the outlet channel rises significantly with the flow rate. The research results of this paper provide a theoretical basis for the distribution of energy loss in reverse power generation of the full tubular pump.
Effect of strengthening by carbon fiber reinforced polymer sheets on the flexural behavior of reinforced self-compacting concrete beams under repeated loads
Authors: Abbas AL-Khafaji Ali Ghanim , Muhammed Sabah Hashim , Jadooe Awad , Abdulredha Muhammad 
Published: March 2024

This study investigates the effect of strengthening self-compacted concrete (SCC) beams using CFRP sheets on flexural behaviour subjected to repeated loads. During the experiment, six rectangular reinforced SCC beams were evaluated; two were reference beams without strengthening, while the remaining four were strengthened with CFRP sheets. The beam’s length, depth, and width are 2100 mm, 300 mm, and 200 mm, respectively. A monotonic load was applied to one of the reference beams, while repeated loads were applied to the remaining (compression cyclic loads). The main parameters studied in this experimental work were the type of loading (monotonic and repeated), the positions of strengthening and the dimensions of CFRP sheets. The flexural behaviour of these beams was investigated through experimental examination by recording the ultimate load and maximum deflection. Meanwhile, the cracks’ pattern and failure modes were observed. The findings of the present study demonstrated that the limited cycles of repeated loads have marginal effect on the flexural behaviour of the beams. This results in an ultimate load reduction of no more than 11%. It was also noted that SCC beams strengthened using CFRP sheets subjected to repeated loads significantly affected the flexural behaviour of these beams. Consequently, the ultimate load of the strengthened beams was improved by up to 18%. Besides, the maximum deflection of the strengthened SCC beams was reduced by 45% compared to those without strengthening. Using strengthening throughout the beams’ entire width and length that are subjected to repeated loads improved their ultimate load to surpass that of non-strengthened beams under monotonic loads by as much as 7%.
Does Spinal Cord Type Predict Intraoperative Neuro-Monitoring Alerts in Scoliosis Correction Surgery? A Systematic Review and Meta-Analysis of Operative and Radiologic Predictors
Authors: Al-Naseem Abdulrahman O. , Al-Naseem Abdulaziz O. , Cawley Derek T. , Aoude Ahmed , Catanzano Anthony A. , Abd-El-Barr Muhammad M. , Sharma Aman , Shafafy Roozbeh 
Published: March 2024

Study Design Systematic literature review and meta-analysis. Objectives Predicting patient risk of intraoperative neuromonitoring (IONM) alerts preoperatively can aid patient counselling and surgical planning. Sielatycki et al established an axial-MRI-based spinal cord classification system to predict risk of IONM alerts in scoliosis correction surgery. We aim to systematically review the literature on operative and radiologic factors associated with IONM alerts, including a novel spinal cord classification. Methods A systematic review and meta-analysis was performed as per the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) Guidelines. A literature search identifying all observational studies comparing patients with and without IONM alerts was conducted. Suitable studies were included. Patient demographics, radiological measures and operative factors were collected. Results 11 studies were included including 3040 patients. Relative to type 3 cords, type 1 (OR = .03, CI = .01-.08, P < .00001), type 2 (OR = .08, CI = .03, P <.00001) and all non-type 3 cords (OR = .05, CI = .02-.16, P < .00001) were associated with significantly lower odds of IONM alerts. Significant radiographic measures for IONM alerts included coronal Cobb angle (MD = 10.66, CI = 5.77-15.56, P < .00001), sagittal Cobb angle (MD = 9.27, CI = 3.28-14.73, P = .0009), sagittal deformity angle ratio (SDAR) (MD = 2.76, CI = 1.57-3.96, P < .00001) and total deformity angle ratio (TDAR) (MD = 3.44, CI = 2.27-4.462, P < .00001). Clinically, estimated blood loss (MD = 274.13, CI = −240.03-788.28, P = .30), operation duration (MD = 50.79, CI = 20.58-81.00, P = .0010), number of levels fused (MD = .92, CI = .43-1.41, P = .0002) and number of vertebral levels resected (MD = .43, CI = .01-.84, P = .05) were significantly greater in IONM alert patients. Conclusions This study highlights the relationship of operative and radiologic factors with IONM alerts.
How to write a “results section” in biomedical scientific research papers?: Critical review
Authors: Habtu Yitagesu , Deressa Wakgari 
Published: March 2024

Introduction The “Results section” is a vital organ of a scientific paper, the main reason why readers come and read to find new information in the paper. However, writing the “Results section” demands a rigorous process that discourages many researchers, leaving their work unpublished and uncommunicated in reputable journals. Therefore, this review aims to describe the content, structure, and key standards of writing the “results section” and suggest practical recommendations to reduce common errors in writing the “results section” of manuscripts. Methods We searched the literature using search terms in the PubMed database. We also traditionally searched for literature from “Google Scholars”, “Google”, and “Websites”. We narrated and summarized finding sections as the content, structure, writing and presenting of data, logical flow of, and advised on the writing of the “results section” of the scientific paper. Result The review suggests guidelines for writing the content and organization, techniques of tabular, and graphical presentation of data in the “results section”. The review also suggests experiences on how to effectively present data in numbers such as percentages, statistical measures such as p-values, and other advanced forms of statistics, Finally, the review recommends relevant points to keep language brevity and logical flow in writing the “results section” of a scientific paper. Conclusions Writing a result section of a scientific paper requires practice and it must be concisely written, logically structured, and supported by a good journal-specific standard to be published.
EBV+ nodal T/NK-cell lymphoma associated with clonal hematopoiesis and structural variations of the viral genome
Authors: Kato Seiichi , Hamada Motoharu , Okamoto Akinao , Yamashita Daisuke , Miyoshi Hiroaki , Arai Haruto , Satou Akira , Gion Yuka , Sato Yasuharu , Tsuyuki Yuta , Miyata-Takata Tomoko , Takata Katsuyoshi , Asano Naoko , Takahashi Emiko , Ohshima Koichi , Tomita Akihiro , Hosoda Waki , Nakamura Shigeo , Okuno Yusuke 
Published: March 2024

Abstract
Epstein-Barr virus (EBV)-positive (EBV+) nodal T- and natural killer (NK)-cell lymphoma is a peripheral T-cell lymphoma (EBV+ nPTCL) that presents as a primary nodal disease with T-cell phenotype and EBV-harboring tumor cells. To date, the genetic aspect of EBV+ nPTCL has not been fully investigated. In this study, whole-exome and/or whole-genome sequencing was performed on 22 cases of EBV+ nPTCL. TET2 (68%) and DNMT3A (32%) were observed to be the most frequently mutated genes whose presence was associated with poor overall survival (P = .004). The RHOA p.Gly17Val mutation was identified in 2 patients who had TET2 and/or DNMT3A mutations. In 4 patients with TET2/DNMT3A alterations, blood cell–rich tissues (the bone marrow [BM] or spleen) were available as paired normal samples. Of 4 cases, 3 had at least 1 identical TET2/DNMT3A mutation in the BM or spleen. Additionally, the whole part of the EBV genome was sequenced and structural variations (SVs) were found frequent among the EBV genomes (63%). The most frequently identified type of SV was deletion. In 1 patient, 4 pieces of human chromosome 9, including programmed death-ligand 1 gene (PD-L1) were identified to be tandemly incorporated into the EBV genome. The 3′ untranslated region of PD-L1 was truncated, causing a high-level of PD-L1 protein expression. Overall, the frequent TET2 and DNMT3A mutations in EBV+ nPTCL seem to be closely associated with clonal hematopoiesis and, together with the EBV genome deletions, may contribute to the pathogenesis of this intractable lymphoma.
Insight into telomere regulation: road to discovery and intervention in plasma drug-protein targets
Authors: Ding Kaixi , Zhangwang Juejue , Lei Ming , Xiong Chunping 
Published: March 2024

Background
Telomere length is a critical metric linked to aging, health, and disease. Currently, the exploration of target proteins related to telomere length is usually limited to the context of aging and specific diseases, which limits the discovery of more relevant drug targets. This study integrated large-scale plasma cis-pQTLs data and telomere length GWAS datasets. We used Mendelian randomization(MR) to identify drug target proteins for telomere length, providing essential clues for future precision therapy and targeted drug development.

Methods
Using plasma cis-pQTLs data from a previous GWAS study (3,606 Pqtls associated with 2,656 proteins) and a GWAS dataset of telomere length (sample size: 472,174; GWAS ID: ieu-b-4879) from UK Biobank, using MR, external validation, and reverse causality testing, we identified essential drug target proteins for telomere length. We also performed co-localization, Phenome-wide association studies and enrichment analysis, protein-protein interaction network construction, search for existing intervening drugs, and potential drug/compound prediction for these critical targets to strengthen and expand our findings.

Results
After Bonferron correction (p < 0.05/734), RPN1 (OR: 0.96; 95%CI: (0.95, 0.97)), GDI2 (OR: 0.94; 95%CI: (0.92, 0.96)), NT5C (OR: 0.97; 95%CI: (0.95, 0.98)) had a significant negative causal association with telomere length; TYRO3 (OR: 1.11; 95%CI: (1.09, 1.15)) had a significant positive causal association with telomere length. GDI2 shared the same genetic variants with telomere length (coloc.abf-PPH 4 > 0.8).

Conclusion
Genetically determined plasma RPN1, GDI2, NT5C, and TYRO3 have significant causal effects on telomere length and can potentially be drug targets. Further exploration of the role and mechanism of these proteins/genes in regulating telomere length is needed.
Exogenous betaine enhances salt tolerance of Glycyrrhiza uralensis through multiple pathways
Authors: Dong Xinping , Ma Xiaomei , Zhao Zhilong , Ma Miao 
Published: March 2024

Abstract
Background
Glycyrrhiza uralensis Fisch., a valuable medicinal plant, shows contrasting salt tolerance between seedlings and perennial individuals, and salt tolerance at seedling stage is very weak. Understanding this difference is crucial for optimizing cultivation practices and maximizing the plant’s economic potential. Salt stress resistance at the seedling stage is the key to the cultivation of the plant using salinized land. This study investigated the physiological mechanism of the application of glycine betaine (0, 10, 20, 40, 80 mM) to seedling stages of G. uralensis under salt stress (160 mM NaCl).

Results
G. uralensis seedlings’ growth was severely inhibited under NaCl stress conditions, but the addition of GB effectively mitigated its effects, with 20 mM GB had showing most significant alleviating effect. The application of 20 mM GB under NaCl stress conditions significantly increased total root length (80.38%), total root surface area (93.28%), and total root volume (175.61%), and significantly increased the GB content in its roots, stems, and leaves by 36.88%, 107.05%, and 21.63%, respectively. The activity of betaine aldehyde dehydrogenase 2 (BADH2) was increased by 74.10%, 249.38%, and 150.60%, respectively. The 20 mM GB-addition treatment significantly increased content of osmoregulatory substances (the contents of soluble protein, soluble sugar and proline increased by 7.05%, 70.52% and 661.06% in roots, and also increased by 30.74%, 47.11% and 26.88% in leaves, respectively.). Furthermore, it markedly enhanced the activity of antioxidant enzymes and the content of antioxidants (SOD, CAT, POD, APX and activities and ASA contents were elevated by 59.55%, 413.07%, 225.91%, 300.00% and 73.33% in the root, and increased by 877.51%, 359.89%, 199.15%, 144.35%, and 108.11% in leaves, respectively.), and obviously promoted salt secretion capacity of the leaves, which especially promoted the secretion of Na+ (1.37 times).

Conclusions
In summary, the exogenous addition of GB significantly enhances the salt tolerance of G. uralensis seedlings, promoting osmoregulatory substances, antioxidant enzyme activities, excess salt discharge especially the significant promotion of the secretion of Na+Future studies should aim to elucidate the molecular mechanisms that operate when GB regulates saline stress tolerance.
NnARF17 and NnARF18 from lotus promote root formation and modulate stress tolerance in transgenic Arabidopsis thaliana
Authors: Libao Cheng , Shiting Liang , Chen Zhao , Shuyan Li 
Published: March 2024

AbstractAuxin response factors (ARFs) play a crucial role in regulating gene expression within the auxin signal transduction pathway, particularly during adventitious root (AR) formation. In this investigation, we identified full-length sequences for ARF17 and ARF18, encompassing 1,800 and 2,055 bp, encoding 599 and 684 amino acid residues, respectively. Despite exhibiting low sequence homology, the ARF17- and ARF18-encoded proteins displayed significant structural similarity and shared identical motifs. Phylogenetic analysis revealed close relationships between NnARF17 and VvARF17, as well as NnARF18 and BvARF18. Both ARF17 and ARF18 demonstrated responsiveness to exogenous indole-3-acetic acid (IAA), ethephon, and sucrose, exhibiting organ-specific expression patterns. Beyond their role in promoting root development, these ARFs enhanced stem growth and conferred drought tolerance while mitigating waterlogging stress in transgenic Arabidopsis plants. RNA sequencing data indicated upregulation of 51 and 75 genes in ARF17 and ARF18 transgenic plants, respectively, including five and three genes associated with hormone metabolism and responses. Further analysis of transgenic plants revealed a significant decrease in IAA content, accompanied by a marked increase in abscisic acid content under normal growth conditions. Additionally, lotus seedlings treated with IAA exhibited elevated levels of polyphenol oxidase, IAA oxidase, and peroxidase. The consistent modulation of IAA content in both lotus and transgenic plants highlights the pivotal role of IAA in AR formation in lotus seedlings.
Transcriptomics and metabolomics reveal the underlying mechanism of drought treatment on anthocyanin accumulation in postharvest blood orange fruit
Authors: Liu Hongbin , Jin Yan , Huang Le , Miao Chouyu , Tang Jiayi , Zhang Huimin , Yin Haojie , Lu Xiaopeng , Li Na , Dai Suming , Gentile Alessandra , Zhang Ling , Sheng Ling 
Published: March 2024

Abstract
Background
Anthocyanins are the most important compounds for nutritional quality and economic values of blood orange. However, there are few reports on the pre-harvest treatment accelerating the accumulation of anthocyanins in postharvest blood orange fruit. Here, we performed a comparative transcriptome and metabolomics analysis to elucidate the underlying mechanism involved in seasonal drought (SD) treatment during the fruit expansion stage on anthocyanin accumulation in postharvest ‘Tarocco’ blood orange fruit.

Results
Our results showed that SD treatment slowed down the fruit enlargement and increased the sugar accumulation during the fruit development and maturation period. Obviously, under SD treatment, the accumulation of anthocyanin in blood orange fruit during postharvest storage was significantly accelerated and markedly higher than that in CK. Meanwhile, the total flavonoids and phenols content and antioxidant activity in SD treatment fruits were also sensibly increased during postharvest storage. Based on metabolome analysis, we found that substrates required for anthocyanin biosynthesis, such as amino acids and their derivatives, and phenolic acids, had significantly accumulated and were higher in SD treated mature fruits compared with that of CK. Furthermore, according to the results of the transcriptome data and weighted gene coexpression correlation network analysis (WGCNA) analysis, phenylalanine ammonia-lyase (PAL3) was considered a key structural gene. The qRT-PCR analysis verified that the PAL3 was highly expressed in SD treated postharvest stored fruits, and was significantly positively correlated with the anthocyanin content. Moreover, we found that other structural genes in the anthocyanin biosynthesis pathway were also upregulated under SD treatment, as evidenced by transcriptome data and qRT-PCR analysis.

Conclusions
The findings suggest that SD treatment promotes the accumulation of substrates necessary for anthocyanin biosynthesis during the fruit ripening process, and activates the expression of anthocyanin biosynthesis pathway genes during the postharvest storage period. This is especially true for PAL3, which co-contributed to the rapid accumulation of anthocyanin. The present study provides a theoretical basis for the postharvest quality control and water-saving utilization of blood orange fruit.