bluuebunny/crossref_metadata_2025_split huggingface dataset:
Program Pemberdayaan Keluarga Dhuafa Membangun Usaha Gorengan dan Nasi Uduk Keluarga Ibu Esi Warga Kelurahan Cireundeu
Authors: Auliya Uswatun Nur , Salsabila Shafa Safitri , Fahri Ahmad , Habibi Mulkan 
Published: February 2025

Kemiskinan adalah masalah sosial yang masih merajalela di kalangan masyarakat, masih banyak orang-orang yang hidup kesusahan. Sebagai seorang umat muslim, kita tentu saja peduli terhadap hal ini yang merupakan sebagai wujud dakwah kita. Oleh karenanya, Muhammadiyah yang merupakan bagian dari gerakan Islam yang berkemajuan mengajarakan unutk melakukan gerakan sosial sesuai dengan teologi Al-Ma’un agar perduli kepada orang—orang yang membuutuhkan. Gerakan sosial ini tertuang dalam pemberdayaan keluarga dhuafa yang bertujuan untuk membantu perekonomian serta usahanya.Pemberdayaan keluarga dhufa yang dilakukan kepada keluarga Ibu Esi adalah bentuk kepedulian kita sebagai mahasiswa Muhammdiyah terhadap lingkungan sekitar. Metode-metode yang digunakan dalam pemberdayaan dhuafa ini adalah teknik observasi, dokumentasi, dan wawancara. Kegiatan ini bertujuan unutk membatu usaha Ibu Esi yang berjualan gorengan agar bisa juga berjualan nasi uduk unutk memenuhi kebutuhan hidup nya dan keluarganya. Pemberdayaan ini memberikan dampak positif terhadap keinginan usaha keluarga Ibu Esi, meningkatkan pendapatan harian mereka, serta memperkuat kemandirian ekonomi keluarga.
Pendampingan Tata Cara Bersuci Dari Hadas dan Najis Pada Jamaah Majlis Ta’lim Masjid Perumahan Dwiga Kota Malang
Authors: Sudari Sudari , Pamungkas Hari , Yusuf Havid , Nidomuddin Muhammad , Husein Ashari 
Published: February 2025

Bersuci ( Thaharah) menjadi perhatian serius dalam Islam. Sebab, syarat utama dalam berbagai aktivitas ibadah terutama dalam ibadah sholat diwajibkan dalam keadaan suci baik suci dari hadas maupun suci dari najis. Jadi bersuci adalah menjadi kunci penting dalam ibadah sholat dan menjadi cermin kesempurnaan keimanan. Pengabdian masyarakat ini dilakukan di majlis ta'lim masjid perumahan dwiga Kota Malang. Tujuan dari pengabdian masyarakat ini adalah untuk memberikan edukasi pemahaman tentang tata cara bersuci. Pengabdian masyarakat ini menggunakan pendekatan metode ABCD ( Asset-Based Community Development). Dengan pengabdian masyarakat ini para jamaah malis ta'lim masjid perumahan dwiga kota Malang semakin bertambah pengetahuan tentang tata cara bersuci, memahami alat yg digunakan untuk bersuci dan dapat membedakan antara hadas dan najis, serta dapat membiasakan diri merawat dan menjaga kebersihan.
Use of Graphic Organizer to Improve Reading Comprehesion
Authors: Rodríguez Hermenegildo Evelyn Germania , Garcia Villao Rosa Tatiana 
Published: February 2025

This study evaluates the effectiveness of graphic organizers as a tool to improve reading comprehension in ninth grade students. A diagnostic test was conducted to identify students' reading comprehension skills. Graphic organizers were applied in classes. A diagnostic test was applied with the use of graphic organizers to measure the impact on students and how they improved their reading comprehension. In addition, interviews were conducted with teachers to get their point of view. The results showed that the use of graphic organizers had a positive impact on the reading comprehension of ninth-grade students. Specifically, students were better able to identify and summarize key information in a text. The graphic organizers helped students focus on the most relevant details to get the essential information. Students increased their ability to comprehend, follow basic instructions, summarize ideas, and identify the main information. Different types of graphic organizers were used but the preferred ones were organizational, synoptic, and flow. This study suggests that graphic organizers are an effective tool to improve reading comprehension in ninth-grade students and that using the organizer according to the type of reading and content promotes students to acquire the ability to read in an organized and captivating way.
Digital immigrants: Leveraging the technology acceptance model to increase digital literacy in older adults
Authors: McGinty Jacqueline , Oest Jess , Divido Jared 
Published: April 2024

AbstractIn “Digital Immigrants: Leveraging the Technology Acceptance Model to Increase Digital Literacy in Older Adults,” the authors delve into the vital importance of digital literacy for supporting older adults in living independently and staying connected with their community. They explore how the Technology Acceptance Model (TAM), which emphasizes the perceived usefulness of technology, can be effectively used to encourage older adults to embrace digital tools. The article highlights that well‐designed technology training can do much more than help older adults live independently; it can also significantly enhance their connections with family, friends, healthcare providers, and community services. Additionally, it offers practical guidelines for creating effective technology training programs that empower older adults to lead more connected, independent, and enriched lives.
Supporting future roles of millennials in rural agriculture retail: The role of technology in continuing education solutions
Authors: Brenny Katie , Yelich Biniecki Susan M. 
Published: April 2024

AbstractRural agriculture retailers, or those engaged in the production of food, fiber, and fuel, are pressed to find just‐in‐time solutions for continual learning with their adult employees, specifically millennials, the generation who will assume future leadership roles. Adult educators in rural settings, or lower populated areas, are encountering rapid technological change and need to transform how they impact learners in and out of the classroom through experiential learning. Technological solutions considered an integral component of Science, Technology, Engineering, and Math (STEM) initiatives, may provide continual learning avenues for millennial employees. This article offers effective ways to engage millennials in agriculture through facilitating peer mentoring, supporting soft skill development, and building the infinite potential of learning and growth in STEM content.
Strengthening inclusive teaching with a MOOC: Adult education and STEM as professional development partners
Authors: Murray‐Johnson Kayon , Dewsbury Bryan 
Published: April 2024

AbstractThis article explores the design and development of a Massive Open Online Course (MOOC) on inclusive teaching. Released in the Fall of 2023, the MOOC is particularly unique because of its intentional use of ethnically diverse voices and multimodal content to include art, music, spoken word, and storytelling. Modules range from Self and Empathy to Classroom Climate and Networks. MOOC production was graciously funded by a grant from the Howard Hughes Medical Institute. At its core, the article will share reflections on the rationale and process, describe how STEM and Adult Education scholar‐practitioners collaborated to infuse adult education and interdisciplinary concepts in MOOC development and outline meaningful implications for the field.
Towards effective collaborations: Reflections and recommendations for adult education and STEM
Authors: Zarestky Jil , Vilen Lauren , Love Hannah 
Published: April 2024

AbstractThis article presents a general and overarching view on partnerships between adult education and STEM disciplines. Drawing from their individual STEM backgrounds, personal perspectives and experiences with such partnerships, and the science of team science, the authors consider the benefits of adult eeducation for STEM, the benefits of STEM for adult education, and some best practices and pitfalls of collaborations. In this way, they address some of the “why?” and “how?” that adult educators may wish to consider as they seek new collaborations, or navigate existing partnerships.
Optimal captured power control of variable speed wind turbine systems: Adaptive dynamic programming approach
Authors: Vu Nga Thi‐Thuy 
Published: April 2024

SummaryAn adaptive optimal controller is proposed in this paper to maximize the captured power of a variable speed wind power system. The proposed controller is a combination of optimal and adaptive control components. The Adaptive Dynamic Programming technique is used to design the optimal control component to overcome the nonlinear problem of system dynamics and ensure stability. While the neural network is used to approximate unknown disturbances and system uncertainties. After that, the adaptive control component fully compensates for the effects of these unknown elements. Neither optimal nor adaptive control components necessitate prior knowledge of system dynamics. Furthermore, the approximation network updates only the weight matrix norm rather than the weight matrix of the neural network in each interval time, which significantly reduces computation. The stability analysis of the closed‐loop system is obtained using Lyapunov stability theory. The correctness and robustness of the control scheme are validated in two different scenarios using MATLAB/Simulink. The presented robust adaptive optimal controller is also compared to other existing controllers to demonstrate its benefits.
Emerging In Vitro and In Vivo Models: Hope for the Better Understanding of Cancer Progression and Treatment
Authors: Yadav Rachana , Mahajan Srushti , Singh Hoshiyar , Mehra Neelesh Kumar , Madan Jitender , Doijad Nandkumar , Singh Pankaj Kumar , Guru Santosh Kumar 
Published: April 2024

AbstractVarious cancer models have been developed to aid the understanding of the underlying mechanisms of tumor development and evaluate the effectiveness of various anticancer drugs in preclinical studies. These models accurately reproduce the critical stages of tumor initiation and development to mimic the tumor microenvironment better. Using these models for target validation, tumor response evaluation, resistance modeling, and toxicity comprehension can significantly enhance the drug development process. Herein, various in vivo or animal models are presented, typically consisting of several mice and in vitro models ranging in complexity from transwell models to spheroids and CRISPR‐Cas9 technologies. While in vitro models have been used for decades and dominate the early stages of drug development, they are still limited primary to simplistic tests based on testing on a single cell type cultivated in Petri dishes. Recent advancements in developing new cancer therapies necessitate the generation of complicated animal models that accurately mimic the tumor's complexity and microenvironment. Mice make effective tumor models as they are affordable, have a short reproductive cycle, exhibit rapid tumor growth, and are simple to manipulate genetically. Human cancer mouse models are crucial to understanding the neoplastic process and basic and clinical research improvements. The following review summarizes different in vitro and in vivo metastasis models, their advantages and disadvantages, and their ability to serve as a model for cancer research.
Polymer Backpack‐Loaded Tissue Infiltrating Monocytes for Treating Cancer
Authors: Kapate Neha , Dunne Michael , Gottlieb Alexander P. , Mukherji Malini , Suja Vineeth Chandran , Prakash Supriya , Park Kyung Soo , Kumbhojkar Ninad , Guerriero Jennifer L. , Mitragotri Samir 
Published: April 2024

AbstractAdoptive cell therapies are dramatically altering the treatment landscape of cancer. However, treatment of solid tumors remains a major unmet need, in part due to limited adoptive cell infiltration into the tumor and in part due to the immunosuppressive tumor microenvironment. The heterogeneity of tumors and presence of nonresponders also call for development of antigen‐independent therapeutic approaches. Myeloid cells offer such an opportunity, given their large presence in the immunosuppressive tumor microenvironment, such as in triple negative breast cancer. However, their therapeutic utility is hindered by their phenotypic plasticity. Here, the impressive trafficking ability of adoptively transferred monocytes is leveraged into the immunosuppressive 4T1 tumor to develop an antitumor therapy. To control monocyte differentiation in the tumor microenvironment, surface‐adherent “backpacks” stably modified with interferon gamma (IFNγ) are developed to stimulate macrophage plasticity into a pro‐inflammatory, antitumor phenotype, a strategy as referred to as Ornate Polymer backpacks on Tissue Infiltrating Monocytes (OPTIMs). Treatment with OPTIMs substantially reduces tumor burden in a mouse 4T1 model and significantly increases survival. Cytokine and immune cell profiling reveal that OPTIMs remodeled the tumor microenvironment into a pro‐inflammatory state.
Room Temperature Phosphorescence from Natural, Organic Emitters and Their Application in Industrially Compostable Programmable Luminescent Tags
Authors: Thomas Heidi , Achenbach Tim , Hodgkinson Isla Marie , Spoerer Yvonne , Kuehnert Ines , Dornack Christina , Schellhammer Karl Sebastian , Reineke Sebastian 
Published: April 2024

AbstractOrganic semiconductors provide the potential of biodegradable technologies, but prototypes do only rarely exist. Transparent, ultrathin programmable luminescent tags (PLTs) are presented for minimalistic yet efficient information storage that are fully made from biodegradable or at least industrially compostable, ready‐to‐use materials (bioPLTs). As natural emitters, the quinoline alkaloids show sufficient room temperature phosphorescence when being embedded in polymer matrices with cinchonine exhibiting superior performance. Polylactic acid provides a solution for both the matrix material and the flexible substrate. Room temperature phosphorescence can be locally controlled by the oxygen concentration in the film by using Exceval as additional oxygen blocking layers. These bioPLTs exhibit all function‐defining characteristics also found in their regular nonenvironmentally degradable analogs and, additionally, provide a simplified, high‐contrast readout under continuous‐wave illumination as a consequence of the unique luminescence properties of the natural emitter cinchonine. Limitations for flexible devices arise from limited thermal stability of the polylactic acid foil used as substrate allowing only for one writing cycle and preventing an annealing step during fabrication. Few‐cycle reprogramming is possible when using the architecture of the bioPLTs on regular quartz substrates. This work realizes the versatile platform of PLTs with less harmful materials offering more sustainable use in future.
The Transpeptidase Sortase A Binds Nucleic Acids and Mediates Mammalian Cell Labeling
Authors: Liu Yingzheng , Lu Zhike , Wu Panfeng , Liang Zhaohui , Yu Zhenxing , Ni Ke , Ma Lijia 
Published: April 2024

AbstractWild‐type sortase A is an important virulence factor displaying a diverse array of proteins on the surface of bacteria. This protein display relies on the transpeptidase activity of sortase A, which is widely engineered to allow protein ligation and protein engineering based on the interaction between sortase A and peptides. Here an unknown interaction is found between sortase A from Staphylococcus aureus and nucleic acids, in which exogenously expressed engineered sortase A binds oligonucleotides in vitro and is independent of its canonical transpeptidase activity. When incubated with mammalian cells, engineered sortase A further mediates oligonucleotide labeling to the cell surface, where sortase A attaches itself and is part of the labeled moiety. The labeling reaction can also be mediated by many classes of wild‐type sortases as well. Cell surface GAG appears involved in sortase‐mediated oligonucleotide cell labeling, as demonstrated by CRISPR screening. This interaction property is utilized to develop a technique called CellID to facilitate sample multiplexing for scRNA‐seq and shows the potential of using sortases to label cells with diverse oligonucleotides. Together, the binding between sortase A and nucleic acids opens a new avenue to understanding the virulence of wild‐type sortases and exploring the application of sortases in biotechnology.
Engineering Phage Nanocarriers Integrated with Bio‐Intelligent Plasmids for Personalized and Tunable Enzyme Delivery to Enhance Chemodynamic Therapy
Authors: Hou Xiao‐Lin , Zhang Bin , Cheng Kai , Zhang Fang , Xie Xiao‐Ting , Chen Wei , Tan Lin‐Fang , Fan Jin‐Xuan , Liu Bo , Xu Qiu‐Ran 
Published: April 2024

AbstractCustomizable and number‐tunable enzyme delivery nanocarriers will be useful in tumor therapy. Herein, a phage vehicle, T4‐Lox‐DNA‐Fe (TLDF), which adeptly modulates enzyme numbers using phage display technology to remodel the tumor microenvironment (TME) is presented. Regarding the demand for lactic acid in tumors, each phage is engineered to display 720 lactate oxidase (Lox), contributing to the depletion of lactic acid to restructure the tumor's energy metabolism. The phage vehicle incorporated dextran iron (Fe) with Fenton reaction capabilities. H2O2 is generated through the Lox catalytic reaction, amplifying the H2O2 supply for dextran iron‐based chemodynamic therapy (CDT). Drawing inspiration from the erythropoietin (EPO) biosynthetic process, an EPO enhancer is constructed to impart the EPO‐Keap1 plasmid (DNA) with tumor hypoxia‐activated functionality, disrupting the redox homeostasis of the TME. Lox consumes local oxygen, and positive feedback between the Lox and the plasmid promotes the expression of kelch ECH Associated Protein 1 (Keap1). Consequently, the downregulation of the antioxidant transcription factor Nrf2, in synergy with CDT, amplifies the oxidative killing effect, leading to tumor suppression of up to 78%. This study seamlessly integrates adaptable T4 phage vehicles with bio‐intelligent plasmids, presenting a promising approach for tumor therapy.
A Computational and Chemical Design Strategy for Manipulating Glycan‐Protein Recognition
Authors: Zhu Qiang , Geng Didi , Li Jingchao , Zhang Jinqiu , Sun Haofan , Fan Zhiya , He Jiahui , Hao Ninghui , Tian Yinping , Wen Liuqing , Li Tiehai , Qin Weijie , Chu Xiakun , Wang Yong , Yi Wen 
Published: April 2024

AbstractGlycans are complex biomolecules that encode rich information and regulate various biological processes, such as fertilization, host‐pathogen binding, and immune recognition, through interactions with glycan‐binding proteins. A key driving force for glycan‐protein recognition is the interaction between the π electron density of aromatic amino acid side chains and polarized C─H groups of the pyranose (termed the CH–π interaction). However, the relatively weak binding affinity between glycans and proteins has hindered the application of glycan detection and imaging. Here, computational modeling and molecular dynamics simulations are employed to design a chemical strategy that enhances the CH–π interaction between glycans and proteins by genetically incorporating electron‐rich tryptophan derivatives into a lectin PhoSL, which specifically recognizes core fucosylated N‐linked glycans. This significantly enhances the binding affinity of PhoSL with the core fucose ligand and enables sensitive detection and imaging of core fucosylated glycans in vitro and in xenograft tumors in mice. Further, the study showed that this strategy is applicable to improve the binding affinity of GafD lectin for N‐acetylglucosamine‐containing glycans. The approach thus provides a general and effective way to manipulate glycan‐protein recognition for glycoscience applications.
Ammonolysis‐Driven Exsolution of Ru Nanoparticle Embedded in Conductive Metal Nitride Matrix to Boost Electrocatalyst Activity
Authors: Yun So Yeon , Lee Sangseob , Jin Xiaoyan , Soon Aloysius , Hwang Seong‐Ju 
Published: April 2024

AbstractExsolution is an effective method for synthesizing robust nanostructured metal‐based functional materials. However, no studies have investigated the exsolution of metal nanoparticles into metal nitride substrates. In this study, a versatile nitridation‐driven exsolution method is developed for embedding catalytically active metal nanoparticles in conductive metal nitride substrates via the ammonolysis of multimetallic oxides. Using this approach, Ti1−xRuxO2 nanowires are phase‐transformed into holey TiN nanotubes embedded with exsolved Ru nanoparticles. These Ru‐exsolved holey TiN nanotubes exhibit outstanding electrocatalytic activity for the hydrogen evolution reaction with excellent durability, which is significantly higher than that of Ru‐deposited TiN nanotubes. The enhanced stability of the Ru‐exsolved TiN nanotubes can be attributed to the Ru nanoparticles embedded in the robust metal nitride matrix and the formation of interfacial Ti3+─N─Ru4+ bonds. Density functional theory calculations reveal that the exsolved Ru nanoparticles have a lower d‐band center position and optimized hydrogen affinity than deposited Ru nanoparticles, indicating the superior electrocatalyst performance of the former. In situ Raman spectroscopic analysis reveals that the electron transfer from TiN to Ru nanoparticles is enhanced during the electrocatalytic process. The proposed approach opens a new avenue for stabilizing diverse metal nanostructures in many conductive matrices like metal phosphides and chalcogenides.
Photoswitchable Endocytosis of Biomolecular Condensates in Giant Vesicles
Authors: Mangiarotti Agustín , Aleksanyan Mina , Siri Macarena , Sun Tsu‐Wang , Lipowsky Reinhard , Dimova Rumiana 
Published: April 2024

AbstractInteractions between membranes and biomolecular condensates can give rise to complex phenomena such as wetting transitions, mutual remodeling, and endocytosis. In this study, light‐triggered manipulation of condensate engulfment is demonstrated using giant vesicles containing photoswitchable lipids. UV irradiation increases the membrane area, which can be stored in nanotubes. When in contact with a condensate droplet, the UV light triggers rapid condensate endocytosis, which can be reverted by blue light. The affinity of the protein‐rich condensates to the membrane and the reversibility of the engulfment processes is quantified from confocal microscopy images. The degree of photo‐induced engulfment, whether partial or complete, depends on the vesicle excess area and the relative sizes of vesicles and condensates. Theoretical estimates suggest that utilizing the light‐induced excess area to increase the vesicle‐condensate adhesion interface is energetically more favorable than the energy gain from folding the membrane into invaginations and tubes. The overall findings demonstrate that membrane‐condensate interactions can be easily and quickly modulated via light, providing a versatile system for building platforms to control cellular events and design intelligent drug delivery systems for cell repair.
Phosphorylation of IDH1 Facilitates Progestin Resistance in Endometrial Cancer
Authors: Li Jingjie , Qin Zuoshu , Li Yunqi , Huang Baozhu , Xiao Qimeng , Chen Peiqin , Luo Yifan , Zheng Wenxin , Zhang Tao , Zhang Zhenbo 
Published: April 2024

AbstractThe progestin regimen is one of the main therapeutic strategies for women with endometrial cancer who undergo conservative management. Although many patients respond well to initial therapy, progestin‐refractory disease inevitably emerges, and the molecular basis underlying progestin resistance has not been comprehensively elucidated. Herein, they demonstrated progestin results in p38‐dependent IDH1 Thr 77 phosphorylation (pT77‐IDH1). pT77‐IDH1 translocates into the nucleus and is recruited to chromatin through its interaction with OCT6. IDH1‐produced α‐ketoglutarate (αKG) then facilitates the activity of OCT6 to promote focal adhesion related target gene transcription to confer progestin resistance. Pharmacological inhibition of p38 or focal adhesion signaling sensitizes endometrial cancer cells to progestin in vivo. The study reveals p38‐dependent pT77‐IDH1 as a key mediator of progestin resistance and a promising target for improving the efficacy of progestin therapy.