bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radiosensitizing effect of a novel CTSS inhibitor by enhancing BRCA1 protein stability in triple‐negative breast cancer cells
Authors: Choi Eun , Jeon Kyung‐Hwa , Lee Hanhee , Mun Gil‐Im , Kim Jeong‐Ahn , Shin Jae‐Ho , Kwon Youngjoo , Na Younghwa , Lee Yun‐Sil 
Published: April 2024

AbstractTriple‐negative breast cancer (TNBC) patients harboring wild‐type breast cancer susceptibility gene 1 (BRCA1) account for most TNBC patients but lack adequate targeted therapeutic options. Although radiotherapy (RT) is the primary treatment modality for TNBC patients, radioresistance is one of the major challenges. RT‐induced increase in cathepsin S (CTSS) causes radioresistance through suppressing BRCA1‐mediated apoptosis of tumor cells, which was induced by CTSS‐mediated degradation of BRCA1. Targeting CTSS may provide a novel therapeutic opportunity for TNBC patients. Publicly available data and human tissue microarray slides were analyzed to investigate the relationship between CTSS and BRCA1 in breast cancer patients. A CTSS enzyme assay and in silico docking analysis were conducted to identify a novel CTSS inhibitor. RO5461111 was used first to confirm the concept of targeting CTSS for radiosensitizing effects. The MDA‐MB‐231 TNBC cell line was used for in vitro and in vivo assays. Western blotting, promoter assay, cell death assay, clonogenic survival assay, and immunohistochemistry staining were conducted to evaluate novel CTSS inhibitors. CTSS inhibitors were further evaluated for their additional benefit of inhibiting cell migration. A novel CTSS inhibitor, TS‐24, increased BRCA1 protein levels and showed radiosensitization in TNBC cells with wild‐type BRCA1 and in vivo in a TNBC xenograft mouse model. These effects were attributed by BRCA1‐mediated apoptosis facilitated by TS‐24. Furthermore, TS‐24 demonstrated the additional effect of inhibiting cell migration. Our study suggests that employing CTSS inhibitors for the functional restoration of BRCA1 to enhance RT‐induced apoptosis may provide a novel therapeutic opportunity for TNBC patients harboring wild‐type BRCA1.
ECM1 and KRT6A are involved in tumor progression and chemoresistance in the effect of dexamethasone on pancreatic cancer
Authors: Shinomiya Yoshiki , Kouchi Yusuke , Harada‐Kagitani Sakurako , Ishige Takayuki , Takano Shigetsugu , Ohtsuka Masayuki , Ikeda Jun‐Ichiro , Kishimoto Takashi 
Published: April 2024

AbstractPancreatic ductal adenocarcinoma (PDAC) has a very poor prognosis. Neoadjuvant chemotherapy is an effective PDAC treatment option, but chemotherapy causes unfavorable side effects. Glucocorticoids (e.g., dexamethasone [DEX]) are administered to reduce side effects of chemotherapy for solid tumors, including pancreatic cancer. Glucocorticoids have both beneficial and detrimental effects, however. We investigated the functional changes and gene‐expression profile alterations induced by DEX in PDAC cells. PDAC cells were treated with DEX, and the cell proliferation, migration, invasion, and chemosensitivity to gemcitabine (GEM) were evaluated. The results demonstrated decreased cell proliferative capacity, increased cell migration and invasion, and decreased sensitivity to GEM. A comprehensive genetic analysis revealed marked increases in ECM1 and KRT6A in DEX‐treated PDAC cells. We evaluated the effects of ECM1 and KRT6A expression by using PDAC cells transfected with those genes. Neither ECM1 nor KRT6A changed the cells’ proliferation, but each enhanced cell migration and invasion. ECM1 decreased sensitivity to GEM. We also assessed the clinicopathological significance of the expressions of ECM1 and KRT6A in 130 cases of PDAC. An immunohistochemical analysis showed that KRT6A expression dominated the poorly differentiated areas. High expressions of these two proteins in PDAC were associated with a poorer prognosis. Our results thus demonstrated that DEX treatment changed PDAC cells’ functions, resulting in decreased cell proliferation, increased cell migration and invasion, and decreased sensitivity to GEM. The molecular mechanisms of these changes involve ECM1 and KRT6A, whose expressions are induced by DEX.
Trajectories of digital flourishing in adolescence: The predictive roles of developmental changes and digital divide factors
Authors: Rosič Jasmina , Schreurs Lara , Janicke‐Bowles Sophie H. , Vandenbosch Laura 
Published: April 2024

AbstractDigital flourishing refers to the positive perceptions of digital communication use in five dimensions: connectedness, positive social comparison, authentic self‐presentation, civil participation, and self‐control. This three‐wave panel study among 1081 Slovenian adolescents (Mage = 15.34 years, 53.8% boys, 80.7% ethnic majority) explored the trajectories of their digital flourishing dimensions over 1 year (2021–2022). Latent class growth analysis identified two classes. Adolescents in the first class reported high levels of digital flourishing, which remained stable over time, whereas those in the second class reported low levels of digital flourishing with decreased self‐control over time. Autonomy‐supportive restrictive, autonomy‐supportive active, and controlling active parental mediation styles, together with high parental digital skills, predicted adolescents' belongingness to the (more digitally flourishing) first class.
Impact of digital technologies on implant surgery in fully edentulous patients: A scoping review
Authors: Lanis Alejandro , Peña‐Cardelles Juan Francisco , Negreiros William Matthew , Hamilton Adam , Gallucci German O. 
Published: April 2024

AbstractBackgroundFor over three decades, digital technologies have been used in Implant Dentistry, beginning with the introduction of planning software for Static Computer‐Assisted Implant Surgery (S‐CAIS). During this time, this field has witnessed the emergence of diverse methodologies and a proliferation of technological advancements. Today, S‐CAIS is a widely adopted procedure for the placement of dental implants in both partially and fully edentulous patients, with Dynamic Computer‐Assisted Surgery (D‐CAIS) and Robotic‐Assisted Implant Surgery (RAIS) rapidly gaining attention among dental professionals. The continuous advancements in this arena are not merely indicative of technological progress; they represent a steadfast dedication to refining precision, enhancing efficiency, and fostering innovation with the goal of optimizing patient outcomes in dental implantology.AimsThe purpose of the following review is to meticulously examine the spectrum of digital technologies available and to describe their protocols, advantages, and shortcomings as well as to evaluate their accuracy in implant surgery in patients with complete edentulism.Materials and MethodsA scoping review was performed following the Joanna Briggs Institute (JBI) protocols, leveraging the population, concept, and context (PCC) framework to construct the research question and determine the inclusion and exclusion criteria.ResultsTwo hundred and sixty‐seven records were identified for screening. After applying all the screening criteria, 41 articles were included for review and qualitative data analysis.DiscussionS‐CAIS, D‐CAIS, and RAIS were identified as the main technologies for computer assisted implant surgery. Their applications, characteristics, protocols and levels of accuracy were compared and described.ConclusionTaking into consideration the limitations of this study, S‐CAIS appears to be the most applied and validated technology in implant surgery for fully edentulous patients followed by D‐CAIS and RAIS being these last two promising initiatives in the field. Despite having similar levels of accuracy, the overall comparison showed a slightly higher values in RAIS followed by D‐CAIS and S‐CAIS.
Sinonasal inverted papilloma and predictors of health‐related quality of life after endonasal endoscopic surgery: A prospective cohort study
Authors: den Heijer Marc C. , Joustra Gonneke E. , Vermeulen Karin M. , Korsten‐Meijer Astrid G. W. , Feijen Robert A. 
Published: April 2024

AbstractObjectivesExisting knowledge on health‐related quality of life (HRQoL) after surgical removal of sinonasal inverted papilloma (IP) is limited. Moreover, predictors for a better or worse post‐operative HRQoL outcome are not known. Our aim was to assess HRQoL in all three health domains (physical, psychological, and social), track its post‐operative trajectory, investigate if pre‐operative observations could predict distinct post‐operative HRQoL outcomes, and evaluate whether physicians' interventions could contribute to improved post‐operative HRQoL.DesignProspective cohort study.SettingTertiary referral hospital.ParticipantsSeventy‐four patients who underwent surgery for an IP were included. They were asked to fill in the Endonasal Endoscopic Sinus and Skull‐Base Surgery Questionnaire (EES‐Q) pre‐operatively, and then 2 weeks, 3 months, and 1 year post‐operatively.Main Outcome MeasuresLinear mixed models analyses were performed to evaluate the overall post‐operative HRQoL and the separate health domains, as well as the impact of specific variables (sex, age, American Society of Anaesthesiologists [ASA] classification, smoker, Krouse staging, pre‐operative EES‐Q score, type of surgery, and post‐operative antibiotics) on HRQoL improvement.ResultsThe total EES‐Q score (p < .001) as well as the physical (p < .001), psychological (p = .049), and the social (p = .002) domains significantly improved post‐operatively. ASA classification (p = .049), pre‐operative EES‐Q score (p < .001) and post‐operative antibiotics (p = .036) were significant variables.ConclusionsOverall HRQoL, as well as each of the three health domains, improved significantly. A higher ASA score, a higher pre‐operative EES‐Q score, and the administration of post‐operative antibiotics were significant predictors for better HRQoL recovery post‐operatively. Further research is necessary to confirm these results.
Factors associated with adjuvant treatment delays in patients treated surgically for head and neck cancer
Authors: Sticker Alan L. , Cannon Sydney T. , Russell Gregory B. , Waltonen Joshua D. 
Published: April 2024

AbstractObjectiveTo determine the patient and treatment characteristics associated with delay in post‐operative radiation therapy (PORT) for patients treated surgically for head and neck squamous cell cancer (HNSCC) at our institution.DesignSingle institution retrospective review.SettingTertiary care academic medical centre.ParticipantsPatients treated surgically for HNSCC who underwent PORT between 2013 and 2016.Main Outcome Measures and ResultsOne hundred forty patients met inclusion criteria. A majority did not start radiotherapy within 6 weeks. Factors associated with a delayed initiation of PORT included length of stay >8 days, 30‐day readmission, no adjuvant chemotherapy, post‐operative complications and fragmented care.ConclusionsA majority of patients did not initiate PORT within the guideline‐recommended 6 weeks. Modifiable risks factors that delay initiation of PORT were identified.
Sebaceous gland atrophy due to seborrheic dermatitis in a patient with alopecia: A potential pitfall
Authors: Zengin Sena , Guthrie Jacey , Zoumberos Nicholas , Hamza Mugahed , Shalin Sara C. 
Published: April 2024

AbstractSeborrheic dermatitis is an inflammatory condition that usually presents with erythema, scaly greasy papules, and plaques affecting sebaceous gland‐rich areas and predominantly involving the face and scalp. The diagnosis of seborrheic dermatitis can often be rendered based on the clinical presentation. However, in certain cases, a biopsy can be useful to distinguish it from clinical mimics such as psoriasis, discoid lupus, and rosacea. Prominent sebaceous gland atrophy without scarring has been well‐described as an important and relatively specific clue for psoriatic or drug‐induced alopecia. However, sebaceous gland atrophy is not specific to psoriasis and has been demonstrated in seborrheic dermatitis, facial discoid dermatitis, and potentially may occur in other inflammatory dermatoses of the scalp. We report a 23‐year‐old female patient presenting with non‐scarring hair loss and histopathological findings demonstrating mild androgenetic alopecia and changes of seborrheic dermatitis with dramatic sebaceous gland atrophy. The patient had no history or evidence of psoriasis clinically. Our case suggests that in patients with seborrheic dermatitis, sebaceous gland atrophy may complicate the evaluation of alopecia biopsies and should be recognized as a pitfall. Seborrheic dermatitis should be included in the differential diagnosis of alopecia biopsies showing prominent sebaceous gland atrophy.
‘Everywhere I call, there's nothing available’: Understanding the alcohol treatment landscape and needs among unstably housed people who use alcohol in Rhode Island
Authors: Collins Alexandra B. , Tan Michael , Smith Megan , Becker Sara J. 
Published: April 2024

AbstractIntroductionAlcohol is a leading cause of morbidity and mortality in the United States and people who are unstably housed are disproportionately impacted by adverse alcohol‐related health outcomes. Addressing the needs of unstably housed people with high‐intensity alcohol use (i.e., heavy episodic use or binge drinking), including those whose goal is not abstinence, is critical to reducing harms among this population. This study explores the alcohol‐related treatment and support needs among unstably housed people who use alcohol.MethodsData collection included participant observation and semi‐structured interviews (n = 25) with unstably housed people with high‐intensity alcohol use. Data were analysed thematically, with attention to structural vulnerability and social‐structural forces at shaping perceptions of and experiences with alcohol treatment.ResultsParticipants underscored how housing instability was critical in precipitating and maintaining heavy alcohol use, with alcohol often used to manage the stress and anxiety related to housing instability. While participants regularly engaged with alcohol treatment programs, program design and barriers to access undermined the effectiveness of these services for participants. Participants described the need for a range of program and service options across a continuum of care to be implemented to support participants in meeting their diverse needs and identified goals regarding alcohol use.Discussion and ConclusionsAlcohol treatment and supports need to be modified so that they include a range of harm reduction and abstinence‐based models to better meet people's diverse needs. Furthermore, treatment must be paired with permanent and affordable housing to address underlying drivers of alcohol‐related harm for unstably housed people.
Reciprocal self‐disclosure makes children feel more loved by their parents in the moment: A proof‐of‐concept experiment
Authors: Brummelman Eddie , Bos Peter A. , de Boer Eva , Nevicka Barbara , Sedikides Constantine 
Published: April 2024

AbstractFeeling loved by one's parents is critical for children's health and well‐being. How can such feelings be fostered? A vital feature of loving interactions is reciprocal self‐disclosure, where individuals disclose intimate information about themselves. In a proof‐of‐concept experiment, we examined whether encouraging reciprocal self‐disclosure in parent‐child dyads would make children feel more loved during the conversation. Participants were 218 children (ages 8–13, 50% girls, 94% Dutch) and one of their parents (ages 28–56, 62% women, 90% Dutch). Parent‐child dyads received a list of 14 questions and took turns asking them each other for 9 min. Dyads were assigned randomly to engage in self‐disclosure (questions invoking escalated intimacy) or small talk (questions invoking minimal intimacy). Before and after, children reported how loved they felt by their parent during the conversation. Self‐disclosure made children feel more loved during the conversation than did small talk. Compared to small talk, self‐disclosure did not instigate conversations that were lengthier or more positive; rather, it instigated conversations that were more emotionally charged (reflecting anger, anxiety, and sadness), social (discussing family and friends), reflective (creating insight), and meaningful (addressing deeply personal topics, including the passing of loved ones). The dyad's gender composition did not significantly moderate these effects. Our research suggests that reciprocal self‐disclosure can make children feel more loved in the moment, uncovers linguistic signatures of reciprocal self‐disclosure, and offers developmental scientists a tool to examine causal effects of reciprocal self‐disclosure in parent‐child dyads. Future work should examine long‐term effects in everyday parent‐child interactions.Research Highlights
How can parents make children feel more loved by them in the moment? We theorize that these feelings can be cultivated through reciprocal self‐disclosure.
In a proof‐of‐concept experiment, we examined effects of reciprocal self‐disclosure versus small talk in 218 parent‐child dyads, with children aged 8−13.
Self‐disclosure (vs. small talk) made children feel more loved during the conversation. Linguistically, self‐disclosure instigated conversations that were more emotionally charged, social, reflective, and meaningful.
This research provides an experimental method to study self‐disclosure in parent‐child dyads and suggests that self‐disclosure can make children feel more loved in the moment.
Is economics self‐correcting? Replications in the American Economic Review
Authors: Ankel‐Peters Jörg , Fiala Nathan , Neubauer Florian 
Published: April 2024

AbstractThis paper reviews the impact of replications published as comments in the American Economic Review between 2010 and 2020. We examine their citations and influence on the original papers' (OPs) subsequent citations. Our results show that comments are barely cited, and they do not affect the OP's citations—even if the comment diagnoses substantive problems. Furthermore, we conduct an opinion survey among replicators and authors and find that there often is no consensus on whether the OP's contribution sustains. We conclude that the economics literature does not self‐correct, and that robustness and replicability are hard to define in economics.
Psychotic‐like anomalous self‐experiences in feeding and eating disorders: Their role in eating psychopathology through the mediation of body uneasiness and embodiment and identity disorders
Authors: Ballerini Massimo , Rossi Eleonora , Cassioli Emanuele , Tarchi Livio , Marchesi Carlo , Tonna Matteo , Stanghellini Giovanni , Ricca Valdo , Castellini Giovanni 
Published: April 2024

AbstractBackgroundPsychotic‐like anomalous self‐experiences (ASEs) are core and early features of schizophrenia spectrum disorders, which have been recently also postulated to underlie embodiment disturbance in feeding and eating disorders (FEDs). The present study was aimed at investigating the interplay between ASEs and specific psychopathology in FED.MethodsNinety persons with Anorexia Nervosa and 41 with Bulimia Nervosa were evaluated with the inventory of psychotic‐like anomalous self‐experiences (IPASE), identity and eating disorders (IDEA), body uneasiness test (BUT), and eating disorder examination questionnaire (EDE‐Q). The same assessment was performed for 92 subjects recruited from the general population. Structural equation modelling was employed to test the role of embodiment/identity disorders in mediating the relationship between ASEs and ED psychopathology.ResultsPatients with FED displayed high scores on IPASE, comparable with people with schizophrenia spectrum disorders. A significant correlation was also demonstrated between IPASE, BUT and EDE‐Q. All IPASE domains were strongly related to feeling extraneous from one's own body by IDEA. All IPASE domains demonstrated a high relationship with BUT Depersonalization scale. A strong correlation was also reported between total scores of IPASE and IDEA. The mediation model confirmed that ASEs impact on FED symptomatology through the mediation of both embodiment/identity disorders and body image.DiscussionAnomalous interoceptive processes may represent the first step of a maladaptive process‐impairing embodiment, selfhood, and identity in FED. Assessment of ASEs might be a valid tool to identify an early‐shared vulnerability of severe disorders characterized by embodiment alterations.
Mobile health technologies in an interventional hybrid study on actinic keratosis: Results from an early phase randomized controlled trial investigating the safety and efficacy of a cytosolic phospholipase A2 inhibitor gel in photodamaged skin
Authors: Ortner Vinzent Kevin , Kilov Kim , Mondragón Alejandro Castillo , Fredman Gabriella , Omland Silje Haukali , Manole Ionela , Laugesen Charlotte Amalie Pind , Havsager Signe , Johansen Berit , Duvold Tore , Isberg Ari Páll , Andersen Anders Daniel , Zibert John R. , Hædersdal Merete 
Published: April 2024

AbstractHybrid trials are a new trend in dermatological research that leverage mobile health technologies to decentralize a subset of clinical trial elements and thereby reduce the number of in‐clinic visits. In a Phase I/IIa randomized controlled hybrid trial, the safety and efficacy of an anti‐proliferative and anti‐inflammatory drug inhibiting cytosolic phospholipase A2 (AVX001) was tested using 1%, 3% or vehicle gel in 60 patients with actinic keratosis (AK) and assessed in‐clinic as well as remotely. Over the course of 12 weeks, patients were assessed in‐clinic at baseline, end of treatment (EOT) and end of study (EOS), as well as 9 times remotely on a weekly to biweekly basis. Safety outcomes comprising local skin reactions (LSR; 0–5), adverse events (AE) and cosmesis, were graded in‐clinic and remotely using patient‐obtained smartphone photographs (PSPs) and questionnaires; efficacy was assessed in‐clinic based on clinically visible clearance of AK target area of >50%. A total of 55 participants (91.7%) completed the treatment course. The average submission rate of PSPs was high (≥85%), of which 93% were of sufficient quality. No serious AE were reported and only two experienced temporary LSR >2 (scale 0–4) and cosmesis remained stable throughout the study. Based on the mild AE and LSR profile, daily application of AVX001 gel for 1 month appears safe, tolerable, and cosmetically acceptable for use in patients with AK. At EOT, AVX001 achieved a subtle treatment response with clearance of AK target area of >50% in 18% of patients. Remote and in‐clinic assessments of LSRs were in high agreement, suggesting that the use of mobile health technologies in early‐phase hybrid studies of AK does not compromise patient safety.