bluuebunny/crossref_metadata_2025_split huggingface dataset:
Finite control set model predictive control of three-port converter for interfacing a PV–battery energy storage system to a three-phase stand-alone AC system
Authors: Preeti Gangashetty A , Karthikeyan Anbalagan 
Published: March 2024

Abstract
This paper proposes a multiport bidirectional non-isolated converter topology that provides advantages in terms of simultaneous multiple operations, single-stage conversion, high power density and reduced power losses due to the lower number of switches. The proposed multiport converter uses a centralized non-linear controller known as a finite control set model predictive controller to manage the flow of power between different ports. It deals with the parallel operation of photovoltaic and battery energy storage systems for stand-alone alternating current (AC) systems. The converter connects the lower voltage battery to the photovoltaic port using a bidirectional buck/boost converter and the photovoltaic port is linked to the stand-alone AC load through a three-phase full-bridge inverter. Each leg of the three-phase converter will act as a bidirectional direct current (DC)/DC converter as well as an inverter simultaneously. Only six switches manage the power transfer between all the connected ports of photovoltaic–battery energy storage system linked to the stand-alone AC load. The proposed multiport converter is mathematically modelled and controlled by a finite control set model predictive controller. The system is validated in simulation (1-kW rating) and experimental environment (200-W rating). The hardware prototype is developed in the laboratory and the controller is implemented on the field-programmable gate array board. Two independent case studies are carried out to validate the efficacy of the system. The first scenario is for a change in solar irradiance, while the second scenario is for a change in the output load.
Inaccurately Reported Statin Use Affects the Assessing of Lipid Profile Measures and Their Association with Coronary Artery Disease Risk
Authors: Ivanova Anna A , Gardner Michael S , Kusovschi Jennifer D , Parks Bryan A , Schieltz David M , Bareja Akshay , McGarrah Robert W , Kraus William E , Kuklenyik Zsuzsanna , Pirkle James L , Barr John R 
Published: March 2024

Abstract

Background
Lipid profiling is central for coronary artery disease (CAD) risk assessment. Nonadherence or unreported use of lipid-lowering drugs, particularly statins, can significantly complicate the association between lipid profile measures and CAD clinical outcomes. By combining medication history evaluation with statin analysis in plasma, we determined the effects of inaccurately reported statin use on lipid profile measures and their association with CAD risk.

Methods
We compared medication history of statin use with statin concentration measurements, by liquid chromatography–tandem mass spectrometry, in 690 participants undergoing coronary angiography (63 ± 11 years of age). Nominal logistic regression was employed to model CAD diagnosis with statin measurements, phenotypic, and lipid profile characteristics.

Results
Medication history of statin use was confirmed by statin assay for 81% of the patients. Surprisingly, statins were detected in 46% of patients without statin use records. Nonreported statin use was disproportionately higher among older participants. Stratifying samples by statin history resulted in underestimated LDL-lipid measures. Apolipoprotein B concentrations had a significant inverse CAD association, which became nonsignificant upon re-stratification using the statin assay data.

Conclusions
Our study uncovered prominent discrepancies between medication records and actual statin use measured by mass spectrometry. We showed that inaccurate statin use assessments may lead to overestimation and underestimation of LDL levels in statin user and nonuser categories, exaggerating the reverse epidemiology association between LDL levels and CAD diagnosis. Combining medication history and quantitative statin assay data can significantly improve the design, analysis, and interpretation of clinical and epidemiological studies.
Flexible Bayesian inference on partially observed epidemics
Authors: Wang Maxwell H , Onnela Jukka-Pekka 
Published: March 2024

Abstract
Individual-based models of contagious processes are useful for predicting epidemic trajectories and informing intervention strategies. In such models, the incorporation of contact network information can capture the non-randomness and heterogeneity of realistic contact dynamics. In this article, we consider Bayesian inference on the spreading parameters of an SIR contagion on a known, static network, where information regarding individual disease status is known only from a series of tests (positive or negative disease status). When the contagion model is complex or information such as infection and removal times is missing, the posterior distribution can be difficult to sample from. Previous work has considered the use of Approximate Bayesian Computation (ABC), which allows for simulation-based Bayesian inference on complex models. However, ABC methods usually require the user to select reasonable summary statistics. Here, we consider an inference scheme based on the Mixture Density Network compressed ABC, which minimizes the expected posterior entropy in order to learn informative summary statistics. This allows us to conduct Bayesian inference on the parameters of a partially observed contagious process while also circumventing the need for manual summary statistic selection. This methodology can be extended to incorporate additional simulation complexities, including behavioural change after positive tests or false test results.
Accuracy of linear measurements for implant planning based on low-dose cone beam CT protocols: a systematic review and meta-analysis
Authors: Carneiro Ana Luiza E , Reis Isabella N R , Bitencourt Fernando Valentim , Salgado Daniela M R A , Costa Claudio , Spin-Neto Rubens 
Published: March 2024

Abstract

Objectives
The aim of this systematic review was to verify the accuracy of linear measurements performed on low-dose CBCT protocols for implant planning, in comparison with those performed on standard and high-resolution CBCT protocols.

Methods
The literature search included four databases (Pubmed, Web of Science, Embase, and Scopus). Two reviewers independently screened titles/abstracts and full texts according to eligibility criteria, extracted the data, and examined the methodological quality. Risk of bias assessment was performed using the Quality Assessment Tool For In Vitro Studies. Random-effects meta-analysis was used for pooling measurement error data.

Results
The initial search yielded 4684 titles. In total, 13 studies were included in the systematic review, representing a total of 81 samples, while 9 studies were included in the meta-analysis. The risk of bias ranged from medium to low. The main results across the studies indicate a strong consistency in linear measurements performed on low-dose images in relation to the reference methods. The overall pooled planning measurement error from low-dose CBCT protocols was −0.24 mm (95% CI, −0.52 to 0.04) with a high level of heterogeneity, showing a tendency for underestimation of real values. Various studies found no significant differences in measurements across different protocols (eg, voxel sizes, mA settings, or dose levels), regions (incisor, premolar, molar) and types (height vs. width). Some studies, however, noted exceptions in measurements performed on the posterior mandible.

Conclusion
Low-dose CBCT protocols offer adequate precision and accuracy of linear measurements for implant planning. Nevertheless, diagnostic image quality needs must be taken into consideration when choosing a low-dose CBCT protocol.
Centring on students’ needs by engaging in translanguaging shifts
Authors: Wong Chiu-Yin 
Published: March 2024

Abstract
The study reports how an ESOL teacher engaged in translanguaging shifts in a content and language integrated learning classroom in the United States. The study findings, from ethnographic methods and conversation analysis, indicated that the teacher engaged in translanguaging shifts centring on the students’ learning needs. She created a co-learning environment in which she and the students co-developed a poem in an English and a bilingual version. In the process of co-creation, not only did the students learn new content, but their identities were valued and affirmed. With her strong translanguaging stance, the teacher let go of control and learnt from the students instead. Based on the findings, I provide recommendations and practical suggestions for teachers, teacher educators, and school leaders. I argue that translanguaging shifts play a crucial role in translanguaging pedagogy. However, teachers cannot work alone in their implementation; it requires different stakeholders to work together–juntos to ensure student success.
Association of inflammatory markers with incident heart failure or cancer in the HUNT3 and Health ABC population studies
Authors: Bertero Edoardo , Carmisciano Luca , Jonasson Christian , Butler Javed , Maack Christoph , Ameri Pietro 
Published: March 2024

Abstract

Aims
To investigate the relationship between chronic low-grade inflammation, as measured by high-sensitivity C-reactive protein (hsCRP) levels, and incident heart failure (HF) or cancer.

Methods and results
We assessed the relationship between baseline hsCRP concentrations and subsequent HF or cancer in two community-based cohorts, the Trøndelag Health Study (HUNT3) and the Health, Aging and Body Composition (ABC) study. In the latter, the analysis was replicated with interleukin (IL)-1, IL-6, or tumour necrosis factor (TNF)-α instead of hsCRP. In HUNT3, hsCRP was measured in 47 163 subjects (mean age 52.3 ± 15.8 years). During a median follow-up of 12.1 years, 2034 (4.3%) individuals developed HF and 5024 (10.7%) cancer, with 442 (0.9%) being diagnosed with both. After adjusting for age, male sex, diabetes, obesity, previous or current smoking, and comorbidities, elevated baseline hsCRP was associated with a higher risk of HF or cancer [hazard ratio (HR) 1.09; 95% confidence interval (CI), 1.07–1.10]. In the Health ABC study, hsCRP levels were assessed in 2803 participants, who had a mean age of 72.6 ± 2.9 years and a higher burden of comorbidities than in HUNT3. During a median follow-up of 8.2 years, HF and cancer were diagnosed in 346 (12.3%) and 776 (27.7%) subjects, respectively, with 77 (2.7%) having both conditions. After adjusting for the same variables used for the HUNT3 cohort, hsCRP remained significantly associated with incident HF or cancer (HR 1.11; 95% CI, 1.05–1.18), as were IL-1 (HR 1.15; 1.07–1.24), IL-6 (HR 1.09; 1.02–1.17), and TNF-α (HR 1.15; 1.07–1.24).

Conclusion
A state of chronic, low-grade inflammation captured by an increase in hsCRP levels is associated with an increased risk of developing HF or cancer, with potential implications for clinical trials with anti-inflammatory therapies.
Eco-Patents at the Crossroads Between Technological Neutrality and Environmental Sensitivity
Authors: Iaia Vincenzo 
Published: March 2024

Abstract
In a world where global warming and the consequent melting of glaciers seem to have become an irreversible trend, the growing demand for energy and natural resources can be met only if businesses actively foster the green conversion of their strategies and activities. Although primarily devoted to the promotion of technological innovation as such, patent law could play a crucial role in the fight against climate change by favoring those intangibles that are compatible with the environmental imperative. The aim of this paper is to assess the desirability of a patent system that is sensitive and permeable to the need for environmental neutrality as against a system that is neutral to technological innovation. The assessment of this tension is made by focusing on two relevant issues arising in the registration phase: (i) the opportunity to introduce an accelerated procedure for green patents both at the national and at the European level; (ii) the possibility of denying the patentability of highly polluting inventions based on ordre public considerations as well as on other provisions, like Art. 81quinquies of the Italian Intellectual Property Code.
Can extended health communication improve newly settled refugees’ health literacy? A quasi-experimental study from Sweden
Authors: Al-Adhami Maissa , Durbeej Natalie , Daryani Achraf , Wångdahl Josefin , Larsson Elin C , Salari Raziye 
Published: March 2024

Abstract
Structural and contextual factors such as limited work and housing opportunities negatively affect the health and well-being of newly settled refugee migrants in receiving high-income countries. Health promotion initiatives aiming at strengthening health and integration have been tried out within the Swedish Introduction program for refugee migrants. However, longitudinal evaluations of these interventions are rare. The aim of the current study was to compare the effectiveness of a regular and an extended civic orientation course with added health communication and examine whether the latter would improve self-rated health and psychological well-being, health literacy and social capital among newly settled refugee migrants in Sweden. Pre- and post-assessment questionnaires were collected from the intervention group receiving the extended course (n = 143) and a control group receiving the regular course (n = 173). Linear mixed models and chi-square analyses showed a significant increase with a small effect size (0.21) in health literacy in the intervention group. However, there were no significant changes in emotional and practical support, general self-rated health or psychological well-being. The findings indicate that added health communication provided embedded in the civic orientation course can increase health literacy. However, further longitudinal studies are needed to confirm the sustainability of the observed effect and examine whether these short-term improvements in health literacy translate to long-term advances in health and integration.
CaSTH2 disables CaWRKY40 from activating pepper thermotolerance and immunity against Ralstonia solanacearum via physical interaction
Authors: Cheng Xingge , Wan Meiyun , Song Yuqiu , Liu Qian , Hu Xiaohui , Chen Xiufang , Zhang Xujing , Zhang Yapeng , Wu Ruijie , Lu Qiaoling , Huang Yu , Lv Jingang , Cai WeiWei , Guan Deyi , Yang Sheng , He Shuilin 
Published: March 2024

Abstract
CaWRKY40 coordinately activates pepper immunity against Ralstonia solanacearum infection (RSI) and high temperature stress (HTS), forms positive feedback loops with other positive regulators and is promoted by CaWRKY27b/CaWRKY28 through physical interactions; however, whether and how it is regulated by negative regulators to function appropriately remain unclear. Herein, we provide evidence that CaWRKY40 is repressed by a SALT TOLERANCE HOMOLOG2 in pepper (CaSTH2). Our data from gene silencing and transient overexpression in pepper and epoptic overexpression in Nicotiana benthamiana plants showed that CaSTH2 acted as negative regulator in immunity against RSI and thermotolerance. Our data from BiFC, CoIP, pull down, and MST indicate that CaSTH2 interacted with CaWRKY40, by which CaWRKY40 was prevented from activating immunity or thermotolerance-related genes. It was also found that CaSTH2 repressed CaWRKY40 at least partially through blocking interaction of CaWRKY40 with CaWRKY27b/CaWRKY28, but not through directly repressing binding of CaWRKY40 to its target genes. The results of study provide new insight into the mechanisms underlying the coordination of pepper immunity and thermotolerance.
Harnessing the power of microbes: Enhancing soybean growth in an acidic soil through AMF inoculation rather than P-fertilization
Authors: Wen Zhongling , Yang Minkai , Fazal Aliya , Han Hongwei , Lin Hongyan , Yin Tongming , Zhu Yuelin , Yang Shouping , Niu Kechang , Sun Shucun , Qi Jinliang , Lu Guihua , Yang Yonghua 
Published: March 2024

Abstract
The low phosphorus (P) availability of acidic soils severely limits leguminous plant growth and productivity. Improving the soil P nutritional status can be achieved by increasing the P-content through P-fertilization or stimulating the mineralization of organic P via arbuscular mycorrhizal fungi (AMF) application; however, their corresponding impacts on plant and soil microbiome still remain to be explored. Here, we examined the effects of AMF-inoculation and P-fertilization on the growth of soybean with different P-efficiencies, as well as the composition of rhizo-microbiome in an acidic soil. The growth of recipient soybean NY-1001, which has a lower P-efficiency, was not significantly enhanced by AMF-inoculation or P-fertilization. However, the plant biomass of higher P-efficiency transgenic soybean PT6 was significantly increased by 46.74%–65.22% through AMF-inoculation. Although there was no discernible difference in plant biomass between PT6 and NY-1001 in the absence of AMF-inoculation and P-fertilization, PT6 had approximately 1.9–2.5 times the plant biomass of NY-1001 after AMF-inoculation. Therefore, the growth advantage of higher P-efficiency soybean was achieved through the assistance of AMF rather than P-fertilization in available P-deficient acidic soil. Most nitrogen (N)-fixing bacteria and some functional genes related to N-fixation were abundant in endospheric layer, as were the P-solubilizing Pseudomonas plecoglossicida, and annotated P-metabolism genes. These N-fixing and P-solubilizing bacteria were positive correlated with each other. Lastly, the two most abundant phytopathogenic fungi species accumulated in endospheric layer, they exhibited positive correlations with N-fixing bacteria, but displayed negative interactions with the majority of the other dominant non-pathogenic genera with potential antagonistic activity.
Multi-omics analysis reveals key regulatory defense pathways and genes involved in salt tolerance of rose plants
Authors: Ren Haoran , Yang Wenjing , Jing Weikun , Shahid Muhammad Owais , Liu Yuming , Qiu Xianhan , Choisy Patrick , Xu Tao , Ma Nan , Gao Junping , Zhou Xiaofeng 
Published: March 2024

AbstractSalinity stress causes serious damage to crops worldwide, limiting plant production. However, the metabolic and molecular mechanisms underlying the response to salt stress in rose (Rosa spp.) remain poorly studied. We therefore performed a multi-omics investigation of Rosa hybrida cv. Jardin de Granville (JDG) and Rosa damascena Mill. (DMS) under salt stress to determine the mechanisms underlying rose adaptability to salinity stress. Salt treatment of both JDG and DMS led to the buildup of reactive oxygen species (H2O2). Palisade tissue was more severely damaged in DMS than in JDG, while the relative electrolyte permeability was lower and the soluble protein content was higher in JDG than in DMS. Metabolome profiling revealed significant alterations in phenolic acid, lipids, and flavonoid metabolite levels in JDG and DMS under salt stress. Proteome analysis identified enrichment of flavone and flavonol pathways in JDG under salt stress. RNA sequencing showed that salt stress influenced primary metabolism in DMS, whereas it substantially affected secondary metabolism in JDG. Integrating these datasets revealed that the phenylpropane pathway, especially the flavonoid pathway, is strongly enhanced in rose under salt stress. Consistent with this, weighted gene coexpression network analysis (WGCNA) identified the key regulatory gene chalcone synthase 1 (CHS1), which is important in the phenylpropane pathway. Moreover, luciferase assays indicated that the bHLH74 transcription factor binds to the CHS1 promoter to block its transcription. These results clarify the role of the phenylpropane pathway, especially flavonoid and flavonol metabolism, in the response to salt stress in rose.
Numerical study of PCM-integrated solar still efficiency enhancement
Authors: Aftiss Reda , Najim Monssif , Hissouf Mohamed 
Published: March 2024

Abstract
This research paper provides a detailed comparison of three types of solar stills: the conventional passive solar still (still-I), the solar still with paraffin wax as a phase change material (PCM) (still-II) and the solar still with PCM coupled to a storage tank (still-III). The study involves a numerical investigation across six regions of Morocco during typical days of each season of the year. The paper formulates and solves the thermal energy balance equations for the different components of the solar stills and storage tank. The numerical simulation is validated by comparing the results with existing experimental and numerical data. The study shows that a portion of the energy produced during the day is stored in the PCM, which can be utilized at night. In addition, the storage tank plays an active role in improving the yield of the passive solar still, indicating the advantage of the new configuration. Thus, the productivity of still-III during typical days of spring, summer and autumn exceeds that of still-II and still-I. The maximum value of still-III was obtained in region five of Morocco (Marrakech) in spring with 8.6 kg ${\mathrm{m}}^{-2}$. However, the highest energy efficiency was achieved in region 1 (Agadir) with 76.05%, while the maximum exergy was reached in region five (Marrakech) in spring with 7.09%.
Diagnosing Polyomavirus Nephropathy Without a Biopsy: Validation of the Urinary Polyomavirus-Haufen Test in a Proof-of-Concept Study Including Uromodulin Knockout Mice
Authors: Nickeleit Volker , Butcher Dalton , Thompson Bawana D , Rivier Lauraine H , Singh Harsharan K 
Published: March 2024

Abstract

Background
Polyomavirus (PyV) nephropathy (PyVN) leads to kidney transplant dysfunction and loss. Since a definitive diagnosis requires an invasive kidney biopsy, a timely diagnosis is often hampered. In this clinical dilemma the PyV haufen-test, centering around the detection of 3-dimensional PyV aggregates in the urine, might provide crucial diagnostic information.

Methods
A multistep experimental design was used. The hypothesis was that PyV-haufen form within the kidneys under high concentrations of uromodulin, a kidney-specific protein and that PyV-haufen are, therefore, kidney-specific disease biomarkers.

Results
The first investigative step showed colocalization of uromodulin with aggregated PyV (1) in 10 kidneys with PyVN by immunohistochemistry, (2) in urine samples containing PyV-haufen by electron microscopy/immunogold labeling (n = 3), and (3) in urine samples containing PyV-haufen by immunoprecipitation assays (n = 4). In the in vitro experiments of the next step, only high uromodulin concentrations (≥1.25 mg/mL) aggregated PyV, as is expected to occur within injured nephrons. In contrast, in voided urine samples (n = 59) uromodulin concentrations were below aggregation concentrations (1.2−19.6 µg/mL). In the third investigative step, none of 11 uromodulin−/− knockout mice (0%) with histologic signs of PyVN showed urinary PyV-haufen shedding, compared with 10 of 14 uromodulin+/+ wild-type mice (71%).

Conclusions
PyV-haufen form within kidneys under high uromodulin concentrations. Thus, PyV-haufen detected in the urine are specific biomarkers for intrarenal disease (ie, definitive PyVN).