bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of HIV infection in young male candidates scheduled for military recruitment and whole population in Turkey
Authors: Tok Duran , Turhan Vedat , Ozenc Salim , Karagoz Ergenekon , Mert Gurkan 
Published: February 2025

Objective: The aim of this study is to investigate the epidemiology and recent incidence of HIV infection among young male candidates scheduled for military recruitment and whole young population in Turkey, a country previously known as markedly low prevalence of HIV infection.
Materials and Methods: In the present study, the medical records from respective health institutions between the years 2007 and 2013 of male candidates scheduled for recruitment from recruitment offices serving under the National Defence Ministry of Turkish Republic, diagnosed with HIV infection and as such judged as unfit for service were requested.
Results: While the total number of new HIV/AIDs cases in 2000 was 157, a fourfold increase (589) was recorded in the year 2010, and reaching 1,068 by the year 2012. Considering, data from the national statistics, in the year 2013 (including the month of November), a total of 7050 HIV positive cases were reported and of all the cases 4,931 (72%) consisted of males. At the same time, an important part of this group falls into the 18-45 year group category.
Conclusion: As a conclusion, the prevalence of HIV infection in Turkey remains still low as compared to that of current global figures but the case numbers of HIV positive candidates of recruits and young people in the whole population are increasing alarmingly in significant manner due to every new coming year. So, programs targeted at identifying high risk groups and increasing the testing rates and preventive measures about HIV infection should be improved and developed
A Child with Hallermann-Streiff Syndrome; as an Infrequent Cause of Hypotrichosis and Cataract
Authors: Kaba Sultan , Dogan Murat , Ceylan Nesrin , Bulan Keziban , Demir Nihat , Dogan Sekibe Zehra , Kocaman Selami 
Published: February 2025

In present case report, four-months-old boy who referred to our pediatric endocrinology outpatient clinic from department of ophthalmology due to evaluation of endocrine and metabolic disorders for cataract was discussed. The characterized features of patient were hypotrichosis, microphthalmia, nystagmus, strabismus, congenital cataract, beaked nose, micrognathia,scaphocephaly, frontal and parietal bossing. The case has typical dysmorphic physical examination findings that appropriate diagnostic features to rare Hallermann-Streiff syndrome.
Types of herniated discs and outcomes of lumbar microsurgical discectomy with extended foraminotomy among young Turkish army personnel
Authors: Eroğlu Ahmet , Günaydın Ahmet , Göçmen Selçuk , Pusat Serhat , Atabey Cem 
Published: February 2025

Objective: The present study is conducted to evaluate the findings of lumbar disc disease among the young adults who are under hard physical conditions in military service.
Materials and Methods: Data of 454 lumbar disc hernia patients who underwent microsurgical discectomy have been analyzed retrospectively. Patients’ age, predisposing factors, duration of symptoms, levels of disc hernia, intraoperative findings, Visual Analog Scores (VAS), and Oswestry Low Back Pain Disability Questionnaire (ODI) data were reviewed from hospital records.
Results: All patients had severe radiculopathy. The 78% of the patients were smokers. Nevertheless, all recurrent disc patients (100%, n = 14) were heavy smokers. Majority of the patients (n = 424, 95%) had problem in just one vertebral point and the most common affected vertebral section was L4-L5 (n = 287, 59%). Disc herniation was centrolaterally placed in 94% (n = 425) patients. The mean VAS and ODI scores at final follow-up were 1.52 and 13.25 points with a reduction from a mean preoperative 7.08 and 60.45 points, (P < 0.001).
Conclusion: Posterior longitudinal ligaments were intact and mostly centrolateral and subligamentous disc herniation were shown in young adult army personals. The comparable effect of smoking on microvascular circulation at the operation site may be effective on recurrence.
The effects of progressive relaxation method on the patients applied total knee arthroplasty
Authors: Çınar Halise , Çam Rahşan 
Published: February 2025

Objective: The aim of this quasi-experimental study is to depict the effects of progressive relaxation method on the patients who were applied total knee prosthesis.
Material and Methods: The findings of the study were obtained from the patients who applied to Adnan Menderes University Research and Practice Hospital, Clinic of Orthopedics and Traumatology with the diagnosis of gonarthros in October 2014–February 2015.Sample of the study was consisted of 80 patients; 40 in experimental group and 40 in control group. The study findings were collected via patient information forms which showed the patients’ introductive information, and via Visual Analogue Scale in which independent variables of stable-ongoing anxiety inventory were investigated.
Results: According to the results, experimental group patients’ age mean was analyzed as X=62.27±7.98, and control group patients’ X=62.35±9.80. 70% of the experimental group patients were female, and 75% of the control group patients were female, 50% of the patients in the experimental group were found to have any chronicle ilness; 62.5% of them had operation experience in the past; 60% used adjuvant tools; 62.5% used their own techniques to overcome the pain when emerged; and body-mass index mean was X=27.62±3.75. 67.5% of the patients in the control group were found to have any chronicle illness; 60% of them had operation experience in the past;76.2% used adjuvant tools;72.5% used their own techniques to overcome the pain when emerged; and body-mass index mean was X=29.57±5.10.
Conclusion: It is considered that progressive relaxation method which was applied to patients has a positive effect on decreasing the post-operative pain and anxiety.
The problems of patients with stoma and its effects on daily living activities
Authors: Özşaker Esma , Yeşilyaprak Tuğce 
Published: February 2025

Objective: This study was conducted to determine the problems of individuals with stoma and its effects on the daily life activities
Material and Methods: The study was conducted individuals with at least one month's stoma, agreed to participate in the study, over the age of 18 years, between January 1 and June 1, 2016 in individuals attending a General Surgery Clinic of a University. In the study, used survey form was prepared by the researchers in the direction of the literature.
Results: The mean age of patients was 56.67±11.07 and 70.4% were male. When social lives of the individuals were examined after stoma, it was found that 22.2% of them prevented the daily activities of the stoma, 14.8% of them had changed in their family, friends and neighbors relations, The 7.42% were embarrassed due to stoma, The 27.8% of them went to liquid beverage restriction, The 16.7% have decreased appetite due to smell. No statistically significant difference was found between the sexes, pre-stoma education status, stoma type and stoma duration according to daily life activities, nutritional status, mental status, dressing and social life (p> 0,005).
Conclusion: It has been determined that stoma influences social life together with mental problems at individuals and restricts their daily activities.
Waldenstrom macroglobulinemia presenting as plasma cell leukemia associated with hyperviscosity syndrome
Authors: Çiftçiler Rafiye , Sağlam Arzu , Aladağ Elifcan , Haznedaroğlu İbrahim Celalettin 
Published: February 2025

Objective: Waldenstrom macroglobulinemia (WM) is a rare indolent neoplastic disease characterized by a wide range of clinical presentations related to the direct tumor infiltration. The disease is characterized by monoclonal immunoglobulin M protein in the serum and infiltration of bone marrow with lymphoplasmacytic cells.
Case report: We, herein, present an unusual case of WM. A 77-year-old woman admitted to the hospital with fatigue, anorexia, and fever. She had white blood cell elevation and splenomegaly. The patient had no peripheral lymphadenopathy. A large number of plasmablast-like cells were seen in the peripheral blood smear. Laboratory studies revealed a white blood cell count of 54.8 × 103/µl, hemoglobin level of 8.2 g/dl and platelet count was 120 × 103/µl. The diagnosis of WM was established after immunohistochemical analysis of the patient's bone marrow that revealed the presence of a lymphoid/lymphoplasmacytoid-like bone marrow infiltrate along with an elevated serum IgM level. The patient responded to the chemotherapy both clinically and serologically. This case is unusual since numerous plasmablast like cells were seen in peripheral blood smear like plasma cell leukemia at the admission to the hospital.
Conclusion: This is the case report of a patient with Waldenstrom macroglobulinemia presenting like plasma cell leukemia in the first admission adding to the spectrum of clinical presentations seen in this disease. This adds to the wide variety of clinical presentations of Waldenstrom macroglobulinemia.
A retrospective study for the effect of local ozone injection for treatment of musculoskeletal disorders
Authors: Ata Emre 
Published: February 2025

Objective: Aim of this study is to examine the effect of local ozone application on pain in patients who applied to physical medicine and rehabilitation outpatient clinic with knee, shoulder and back pain problems.
Material and Methods: The research was performed by retrospectively investigating records of the patients who consulted the Physical Medicine and Rehabilitation outpatient clinic of our hospital with the complaints about knee, shoulder and low-back pain, who met the inclusion criteria and were applied local (intraarticular or intramuscular) ozone as per the routine protocol. The study was conducted with 25 patients A total of 4 sessions of ozone were administered once weekly. Patients were evaluated using VAS (visual analogue scale) at 3 and 5 weeks.
Results: The mean age of the patients was 57.62 ± 17 (33-97). 64% of the patients had knee pain, 20% had shoulder pain and 16% had back pain. The mean VAS score was 7.44 ± 0.91 before treatment, 5.04 ± 1.45 at 3 weeks, and 3.92 ± 1.57 at 5th week.
Conclusion: Statistically significant improvement was observed in VAS scores according to pre-treatment.
Effect and reliability of Transcranial Magnetic Stimulation on neuropathic pain, depressive symptoms in stroke patients: Preliminary Study
Authors: Türkan Turgay  , Akaltun Mazlum Serdar , Turan Neytullah , Şahin Şengül Kocamer , Altındağ Özlem 
Published: February 2025

Objective: In this paper, we aimed to evaluate the effect of repetitive Transcranial Magnetic Stimulation (rTMS) on central pain in patients with stroke.
Material and Methods: Ten patients who had a stroke history were included in this preliminary study. Patients with middle cerebral artery lesion, first-time stroke, subacute or chronic lesion and no other neurological involvement were included. Patients were examined before and after the first month of treatment with repetitive Transcranial Magnetic Stimulation (rTMS). Visual Analog Scale (VAS) was used for pain scale measurement; Leeds Assessment of Neuropathic Symptoms and Signs Scale (LANSS) and Douleur Neuropathique en 4 Questions (DN4) were used for neuropathic pain level and Beck Depression Inventory (BDI) for depressive mood. All patients received the current treatments and appropriate neurorehabilitation as recommended for the treatment of ischemic stroke
Results: This prospective study included a total of 10 post-stroke patients (mean age 58.2 ± 16.1 years; range 29 to 75, 8 male; 2 female) with neuropathic pain. The mean values of VAS, LANSS, DN4 and BDI scales were significantly decreased after rTMS treatment in all patients.
Conclusion: We discussed the preliminary results of the efficacy and safety of rTMS in the treatment of uncontrolled neuropathic pain. We consider that, rTMS may have significant effect on relief of chronic pain. These clinical parameters can be utilized for the further study of rTMS application in pain control.
A case of primary malignant melanoma of the larynx
Authors: Kaya Özge , Kahraman Dudu Solakoğlu , Diniz Gülden , Demir Gönül 
Published: February 2025

Objective: Malignant melanoma of the larynx is an uncommon tumor type that can be seen as a primary tumor or as a metastasis from a cutaneous primary lesion. Morphological appearances of this tumor are readily confused with the other types of laryngeal cancers. A new case of primary laryngeal malignant melanoma has been presented in this case report .
Case: The patient was a 54-year-old man without any clinical evidence of other cutaneous malignant melanocytic lesions. Microscopically, polygonal-epithelioid tumor cells containing cytoplasmic and nuclear melanin were located under the mucosal squamous epithelial cells. Atypical mitotic figures were also present. Ulceration and disruption of the epithelium weren’t observed. Immunohistochemical studies were positive for S100, HMB-45, Melan-A and vimentin while it was negative for cytokeratin. Based on findings this diagnosis was established.
Anesthesia management in a patient with Zellweger syndrome
Authors: Kılınç Gökhan 
Published: February 2025

Objective: Zellweger syndrome (ZS) is an autosomal recessive disorder in the spectrum of peroxisome biogenesis disorders including punctate and is defined as cerebrohepatorenal syndrome due to multiple congenital anomalies including brain, liver and kidneys. We wanted to draw attention to this issue by sharing our anesthetic experiences in a child with Zellweger syndrome.
Case: Appendectomy was planned by pediatric surgery in a 4 year old and 16 kg male patient who was diagnosed as Zellweger syndrome. Physical examination revealed large forehead, large tongue, small chinhypotony, mental motor retardation, and hepatosplenomegaly. Following the introduction of routine monitors, anesthesia were induced intravenously and maintained with sevoflurane in an 50% oxygen- 50% air mixture. The patient was intubated and ventilated with a safe pressure control mode. The patient was hemodynamically stable during surgery. After spontaneous breathing of the patient, extubation was applied smoothly.
Conclusion: Zellweger syndrome includes alarming features for the anesthesiologist. Before any procedure, the pulmonary condition should be carefully evaluated. Hepatic dysfunction may lead to a change in the metabolism of drugs based on hypoalbuminemia, coagulopathy and liver pathways. Since liver dysfunction may lead to coagulopathy, caution should be exercised when applying regional anesthesia techniques.
The Effects of EGFR Exon 19 747–750 Deletion on the Risk of Developing Lung Cancer
Authors: Ertural Duygu Yolal , Nayır Erdinç , Arpacı Rabia Bozdoğan , Eker Ebru Derici , Eras Nazan , Yıldırım Didem Derici , Akbaş Etem 
Published: February 2025

Objective: Although smoking is the most significant factor in the etiology of lung cancer, other environmental pollutants and genetic predisposition also play major roles in its development. Histopathologically, lung cancers are divided into two major types, as small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). The latter accounts for almost 85% of all lung cancers with a very aggressive course and being associated with a high rate of mortality. Among the genetic mutations with prognostic value in NSCLC, the epidermal growth factor receptor (EGFR) mutation is most frequently found in 50 to 80% of cases. The EGFR is a transmembrane glycoprotein with tyrosine kinase activity which is associated with both normal cell growth and malignant transformations.
Material and Methods: In the present study, we aimed to evaluate the effects of exon 19 747–750 deletion in the EGFR gene on the risk of developing lung cancer and to examine its potential relationship with the different histopathological types of lung cancer. The study sample comprised a total of 178 patients diagnosed with lung cancer at Mersin University, Medical Faculty, Oncology Clinics, and 192 age- and sex-matched healthy individuals as the control group. Deoxyribonucleic acid (DNA) isolation was performed using the standard salt-water precipitation method, while the mutation screening and genotyping analyses were carried out with a polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analyses.
Results: The frequency of mutant EGFR exon-19 deletion in the control group was 15.1%, increasing to 36.9% in the lung cancer group, and increasing the risk of developing lung cancer by 2.64 times (p: 0.014). This increase did not significantly differ between the histopathological types of lung cancer (p: 0.76).
Conclusion: Considering the distribution of lung cancer patients in different age groups, it is obvious that advanced age is a risk factor for the development of EGFR mutation and lung cancers (p<0.001).
Adrenomedullin has effects on hypoxia-inducible factor 1-alpha in hypoxia in several organs of female rats
Authors: Culum Ayşe Asiye , Yürekli Muhittin 
Published: February 2025

Objective: Vascular dysfunction induces impaired O2 delivery and hypoxia, and adrenomedullin (AdM) have a role in hypoxia and angiogenesis. The reaction of the organism exposed to hypoxia and the effect of AdM over HIF-1α has been investigated in this study.
Material and Methods: Female rats were divided into 4 groups (control, hypoxia, control + AdM and hypoxia + AdM). Hypoxia groups were provided hypoxia containing 10% oxygen and 90% nitrogen for 1 week. AdM treatment groups were injected 1.25 nmol/kg AdM for 4 days intraperitoneally. AdM and HIF-1α levels were measured in heart, lung, and kidney tissues with ELISA.
Results: AdM levels increased in hypoxia + AdM group than hypoxia group, however, was not increased in control + AdM group when compared with the control group in heart tissue. Contrarily, AdM decreased in control + AdM group in the kidney, while increased in control + AdM, and hypoxia + AdM groups in the lung when compared to the control group. The HIF-1α level was higher in control + AdM group in the kidney, and hypoxia + AdM group in the lung. HIF-1α levels in heart tissue were decreased in hypoxia group when compared to the control group.
Conclusion: Tissues respond to hypoxic conditions at different times, and at distinct levels. AdM may be used to induce HIF-1α therapeutically before ischemic conditions.
Prognostic Factors Affecting Local Recurrence and Systemic Metastasis in Early Stage Breast Cancer
Authors: Pekkolay Zafer , Işıkdoğan Abdurrahman 
Published: February 2025

Objective: Breast cancer is the most common cancer in women. Mortality in breast cancer is associated with recurrence and metastases. The aim of this study was to determine the causes of local recurrence and metastasis in operated early stage breast cancer.
Material and Methods: The files of the patients diagnosed with operated early stage breast cancer followed up at Dicle University Medical Faculty Medical Oncology Department between 2001-2010 were analyzed retrospectively. The group of patients with recurrence was referred to as the relapse-metastasis group and the other patients were called the remission group. Between these two groups, age, sex, tumor histology, size, presence of lymphovascular invasion, tumor grade molecular properties such as, ER, PR, HER, staging studies; time characteristics, surgical characteristics, time between surgery-chemotherapy and surgery-radiotherapy; The relapse-metastasis group and the remission group were compared in terms of chemotherapy. SPSS 22 was used for statistical analysis. p<0.05 was considered significant.
Results: 479 patients were included in the study. The number of patients in the remission and relapse-metastasis group was 343 and 136, respectively. Tumor diameter was 3.33 cm in the remission group and 4.58 cm in the relapse-metastasis group, and the difference was statistically significant (p<0.01). The percentage of involvement of more than 4 lymph nodes were 30.45% and 55.7% in the remission and relapse-metastasis groups, respectively (p <0.01). The percentage of the lymphovascular invasions were remission group and relapse-metastasis group 46.4% and 80% respectively. The percentage of patients with surgery-chemotherapy time> 1 month was 9.7% and 24% in the remission and relapse-metastasis group, respectively. In remission group 30.9%; relapse-metastasis group 47.7% of the patients had incomplete staging at the time of diagnosis.
Conclusion: The factors determining the recurrence in patients with operated early stage breast cancer were tumor size, number of lymph node involvement, incomplete staging at the time of diagnosis, start chemotherapy later than 1 month.
Vitamin D deficiency in healthy adolescents aged 12–17 years in Kirikkale, Turkey
Authors: Dulkadir Ramazan , Gülerman Hacer Fulya , Bülbül Selda Fatma Hızel 
Published: February 2025

Objective: This study was performed to determine the prevalence of vitamin D deficiency and associated factors in apparently-healthy adolescents in the Central Anatolia region of Turkey where nutritional rickets is common.
Materials and Methods: This prospective cohort study was performed in the Kirikkale province of Central Anatolia, Turkey. Adolescents aged 1 to 17 years old with no health complaints were enrolled between February 2012 and February 2013. Adolescents younger than 12 and older than 17 age, those with chronic diseases, and those using any medications known to affect vitamin D metabolism were excluded. A total of 358 adolescents, consisting of 235 (65.5%) girls and 123 (34.5%) boys with an average age of 14.6 ± 1.58 years, were included in this study. Serum concentrations of 25-hydroxy vitamin D [25(OH)D] and other bone mineralization markers were measured in the summer and winter.
Results: In blood samples, phosphorus (P), alkaline phosphatase (ALP), bone-ALP (B-ALP), parathyroid hormone (PTH), and 25(OH)D levels were considerably lower in female adolescents than in male adolescents. The rate of vitamin D deficiency was higher in girls than in boys. B-ALP level was compared to Vitamin D level in each season; there was no significant relation in winter, but vitamin D level decreased with increasing B-ALP level in summer. B-ALP level was compared to vitamin D level according to sex; there was no significant relation in male adolescents, but vitamin D level decreased while B-ALP level increased in female adolescents.
Conclusion: This study showed that vitamin D deficiency or inadequacy is very common among adolescents, particularly in females in Central Anatolia region of Turkey.
Karakteristik pasien dan rasionalitas penggunaan obat demam berdarah dengue pada pasien anak rawat inap
Authors: Lubis Salmah Handayani , Dasopang Eva Sartika , Siahaan Desy Natalia , Hasanah Fenny , Ndruru Mei Kasih Murni , Aisyah Teti 
Published: February 2025

Penyakit DBD merupakan penyakit menular yang dapat menyerang pada anak. Prinsip utama pengobatan DBD adalah terapi suportif yang dapat menurunkan angka kematian hingga kurang dari 1%, dan pemeliharaan volume cairan sirkulasi. Penelitian ini bertujuan untuk mengetahui distribusi proporsi pasien DBD pada anak berdasarkan usia, jenis kelamin, gejala klinis dan rasionalitas penggunaan obat DBD pada pasien anak yang dirawat di RSUD Dr. Pirngadi Medan. Penelitian ini merupakan penelitian deskriptif nonanalitik dengan desain studi kasus. Data yang menjadi populasi dalam penelitian ini adalah seluruh data rekam medis pasien pada anak terdiagnsoa DBD yang dirawat pada periode tahun 2022 di RSUD Dr. Pringadi Medan. Penelitian ini meyimpulkan pasien DBD anak terbanyak pada kelompok jenis kelamin perempuan (47,6%), usia 0-35 tahun (42,7%), gejala klinis demam (82%) lama demam 4 hari (82,9%). Keluhan terbanyak penyakit DBD anak adalah demam (100%), muntah (81%), mual (75%). Pada evaluasi rasionalitas penggunaan obat pada bagian tepat dosis pemberian analgetik dan antipiretik parasetamol diperoleh 100% (tepat dosis) dan pemberian cairan rumatan ringer laktat 85,36% (tidak tepat dosis).