bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adenomas and Sessile Serrated Lesions in 45- to 49-Year-Old Individuals Undergoing Colonoscopy: A Systematic Review and Meta-Analysis
Authors: Abdallah Mohamed , Mohamed Mouhand F.H. , Abdalla Abubaker O. , Jaber Fouad , Baliss Michelle , Ahmed Khalid , Eckmann Jason , Bilal Mohammad , Shaukat Aasma 
Published: February 2024

INTRODUCTION:
Colorectal cancer (CRC) screening is now recommended at the age of 45 years in the United States. However, information regarding the adenomas detection rate (ADR) and sessile serrated lesions (SSLs) in 45- to 49-year-old individuals is limited. In addition, the impact of lowering the screening age to 45 years on the ADR and the detection rate of SSLs is not well elucidated. This systematic review and meta-analysis aims to report the overall ADR and SSL detection rate in 45- to 49-year-old individuals undergoing colonoscopy.

METHODS:
We searched MEDLINE, EMBASE, SCOPUS, Web of Science, ClinicalTrials.gov, and the Cochrane database from inception through October 2022 to identify studies reporting on ADR and SSL detection rates in 45- to 49-year-old individuals undergoing colonoscopies for all indications. This approach acknowledges the possibility of including individuals undergoing diagnostic colonoscopies or those with increased risk factors for CRC. We also conducted a separate analysis examining ADR in average-risk individuals undergoing screening colonoscopy. The pooled rates with their corresponding 95% confidence intervals (CIs) were generated using the fixed-effects model. I
2 was used to adjudicate heterogeneity.

RESULTS:
Sixteen studies met the inclusion criteria. All studies were retrospective except one; 3 had data from national/local registries. There were 41,709 adenomas detected across 150,436 colonoscopies. The pooled overall ADR was 23.1% (95% CI 19.7%–27.0%, I
2 = 98.6%). The pooled ADR in individuals with average risk of CRC from 7 studies was 28.2% (95% CI 24.6%–32.0%, I
2 = 96.5%). The pooled overall SSL detection rate from 6 studies was 6.3% (95% CI 3.8%–10.5%, I
2 = 97%). The included studies were heterogeneous because of differences in the inclusion and exclusion criteria and patient population.

DISCUSSION:
In 45- to 49-year-old individuals undergoing a colonoscopy for any indication, the ADR and SSL detection rates were 23.1% and 6.3%, respectively. We conclude that these outcomes in 45- to 49-year-olds are comparable with individuals aged 50–54 years.
Endoscopic Ultrasound–Guided vs Endoscopic Retrograde Cholangiopancreatography–Guided Biliary Drainage as Primary Approach to Malignant Distal Biliary Obstruction: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Gopakumar Harishankar , Singh Ritu Raj , Revanur Vakya , Kandula Rajanikanth , Puli Srinivas R. 
Published: February 2024

INTRODUCTION:
Endoscopic ultrasound–guided biliary drainage (EUS-BD) is an alternative to endoscopic retrograde cholangiopancreatography (ERCP)-guided transpapillary drainage in malignant distal biliary obstruction (MDBO). This meta-analysis of randomized controlled trials (RCTs) aims to compare the outcomes of these 2 approaches.

METHODS:
Electronic databases from January 2005 through December 2023 were searched for RCTs comparing outcomes of EUS-BD and ERCP for treating MDBO. Pooled proportions, risk ratio (RR), and odds ratio were calculated using random-effects models.

RESULTS:
Five RCTs comprising 519 patients were included in the final analysis. The pooled RR for overall technical success with EUS-BD compared with ERCP was 1.05 (95% confidence interval [CI] = 0.96–1.16, P = 0.246, I

2
= 61%) and for clinical success was 0.99 (95% CI = 0.95–1.04, P = 0.850, I

2
= 0%). The pooled rate of procedure-related pancreatitis was 7.20% (95% CI = 3.60–13.80, I

2
= 34%) in the ERCP group compared with zero in the EUS-BD group. The pooled RR for stent dysfunction with EUS-BD compared with ERCP was 0.48 (95% CI = 0.28–0.83, P = 0.008, I

2
= 7%). The weighted mean procedure time was 13.43 (SD = 10.12) minutes for EUS-BD compared with 21.06 (SD = 6.64) minutes for ERCP. The mean stent patency was 194.11 (SD = 52.12) days in the EUS-BD group and 187 (SD = 60.70) days in the ERCP group.

DISCUSSION:
EUS-BD is an efficient and safe alternative to ERCP in MDBO. An almost nonexistent risk of procedure-related pancreatitis, lower procedure time, and ease of use make this an attractive primary approach to biliary decompression in centers with expertise.
Invisibilizing Responsibility: The Holocaust Museums of Slovakia and Hungary
Authors: Klacsmann Borbála 
Published: February 2024

Abstract
Facing and coming to terms with the past in post-Holocaust Europe has not only been a moral imperative but also a challenge in scientific, political and social senses. This process was delayed significantly in socialist countries. A part of the development of a post-socialist commemorative structure was the establishment of Holocaust museums which not only serve as a memento of the past but also provide an institutional framework for memorialization, research and education about the Holocaust. However, nationalist political forces jeopardize this process by attempting to whitewash the past in order to preserve a positive picture of the nation. In this paper, I compare the permanent exhibitions of three museums from Slovakia and Hungary in order to illuminate how this struggle influences their exhibition narratives and activities. After examining the narrative strategies of the exhibitions and conducting interviews with museum personnel of the Holocaust Memorial Center (Budapest), the House of Jewish Excellencies (Balatonfüred) and the Sereď Holocaust Museum, it can be inferred that especially the way collaboration, perpetration, and in general, the role of the local non-Jewish population is depicted (or obscured), is inextricably intertwined with political agendas.
Student perceived effectiveness of task-based instructional design of data-driven synonym learning featuring “mini-lecture”
Authors: Yang Yingying , Chen Lin , Tian Xumin 
Published: February 2024

Abstract
This study evaluates student perceived effectiveness of a guided inductive approach for synonym learning through a 36-week, two-round data-driven learning (DDL) and task-based instruction design. Presented as a student-centered “mini-lecture” task, it integrates pre-task training, during-task guidance, and post-task feedback. Data were collected from 23 business English university students via questionnaires and interviews. Results show that learners generally held consistent positive attitudes toward this long-term data-driven learning. Enhanced instruction in the second round underscored the importance of scaffolding, reducing learners’ anxiety, and promoting cognitive development. Task complexity and language proficiency seemed unrelated to learner perceptions. Although task motivations influenced learners’ perceptions, learners with lower motivation were not overwhelmed by technical difficulties involved in DDL, supporting the effectiveness of the long-term practice in improving learners’ corpus query skills. Learners often used their native language to explain key concepts in the “mini-lecture” presentation. The results suggest the task-based “mini-lecture” design is effective and that guided inductive DDL is a promising alternative in language pedagogy. Based on the findings, a task-based data-driven synonym learning model is proposed.
From click to calories: Navigating the impact of food delivery apps on obesity
Authors: Willie Michael Mncedisi , Maqbool Mudasir , Qadir Afshana 
Published: February 2024

Abstract
The rise of food delivery apps has ushered in a new era in the way we consume meals, bringing both unprecedented convenience and concerns about their impact on obesity. These digital platforms, exemplified by industry giants like Uber Eats and DoorDash, have transformed the dining experience from a trip to the kitchen to a simple click on our smartphones. While the seamless accessibility to a diverse range of culinary options is undoubtedly a game-changer, it comes with a flip side. The ease of ordering restaurant-quality meals, fast food, or groceries through these apps may contribute to less health-conscious dietary choices. The convenience factor might inadvertently lead to an overreliance on high-calorie and less nutritious options, potentially exacerbating the obesity epidemic. As we navigate this digital culinary landscape, it becomes imperative to understand and address the implications of this technological shift on public health. Research and awareness campaigns are vital to comprehending the nuanced relationship between food delivery apps and obesity, ensuring that the ease of a click does not translate into a surge in calories. Balancing the advantages of convenience with the potential risks to our health is paramount as we strive for a harmonious coexistence with these technological innovations.
Was die Teilhabe am Arbeitsmarkt fördert. Die unsichtbaren Faktoren
Authors: Skarabis Noemi , Preissner Lisa , Faller Gudrun , Walter-Klose Christian , Baumgart Verena 
Published: February 2024

Zusammenfassung
Das Projekt IGel-A beschäftigt sich mit der Frage, welche Bedingungen die Inklusion von Menschen mit psychischen, kognitiven oder neurologischen Beeinträchtigungen auf dem allgemeinen Arbeitsmarkt fördern oder hemmen, und welche Anforderungen vor diesem Hintergrund an Ansätze und Strategien für die Inklusionsberatung zu stellen sind. Auszüge einer systematischen Literaturrecherche zeigen auf, wie informelle Einflussfaktoren die Inklusion fördern können.
Auswirkungen von Diskriminierung auf die physische und psychische Gesundheit
Authors: Lutterbach Sebastian , Beelmann Andreas 
Published: February 2024

Zusammenfassung
Der Beitrag fokussiert den Einfluss von Erfahrungen mit ethnischer Diskriminierung auf die psychische und physische Gesundheit. Es werden zentrale Befunde zu den Auswirkungen von ethnischer Diskriminierung auf verschiedene Gesundheitsindikatoren dargestellt. Anschließend werden Ansätze und Möglichkeiten zur Prävention von Diskriminierung und zur Förderung von Toleranz aufgezeigt.
Mediengestaltung und Diversity aus sozialpsychologischer Perspektive
Authors: Förster Jens , Nußbaum Manfred 
Published: February 2024

Zusammenfassung
Forschung zeigt, dass Vorurteile Mitglieder stigmatisierter Gruppen krank machen können. Medienschaffende können versuchen, Publikationen diversity-sensibel zu gestalten. Dem stehen allerdings unbewusste Stereotypisierungsprozesse entgegen: Manchmal diskriminieren Menschen, ohne es zu wollen. Auf dieser Grundlage werden vorliegend Empfehlungen gegeben.
Berufliche Teilhabe schwerbehinderter Frauen in Westfalen-Lippe
Authors: Reinersmann Annika 
Published: February 2024

Zusammenfassung
Die berufliche Teilhabe von Leistungsnehmer:innen, die Leistungen des SGB IX beziehen, ist bisher weitestgehend ungeklärt. Um mögliche Diskriminierungspraktiken für die besonders vulnerable Gruppe, Frauen mit Behinderung, auszuschließen, wurde im LWL-Inklusionsamt Arbeit des Landschaftsverbands Westfalen-Lippe die Datenlage aufgearbeitet. Hieraus lassen sich erfreulicherweise keine Belege für eine Schlechterstellung der Leistungsnehmerinnen ableiten. Doch der weitere Datenaufbau ist geboten.
Stadtentwicklung unter den Prämissen von Gesundheit und Vielfalt
Authors: Köckler Heike , Brüggemann Julia , Walter-Klose Christian 
Published: February 2024

Zusammenfassung
Stadtentwicklung kann mit vielfältigen Instrumenten die natürliche und gebaute Umwelt als Gesundheitsdeterminanten gestalten. Partizipation von Öffentlichkeit spielt in jedem Verfahren eine zentrale Rolle. Dennoch gelingt es in den bestehenden Strukturen nicht allen Gruppen einer diversen Stadtgesellschaft in gleichem Maße eine wirkungsvolle Beteiligung zu ermöglichen. Dies ist eine Ursache für soziale Ungleichheit bei Gesundheit.
Sexuelle Gesundheit von Personen mit Migrationshintergrund in Deutschland
Authors: Wiessner Christian , Pietras Laura , Cerwenka Susanne , Briken Peer 
Published: February 2024

Zusammenfassung
Personen mit Migrationshintergrund (PmM) haben ein erhöhtes Risiko, an sexuell übertragbaren Infektionen zu erkranken. Präventionsangebote wie die HPV-Impfung und das Chlamydien-Screening werden von PmM seltener in Anspruch genommen als von Nicht-Migranten. Zentrale Barrieren im Kontext sexueller Gesundheit sind Sprachprobleme und das Gefühl von Scham. Es sollten daher Anstrengungen unternommen werden, um diese Barrieren abzubauen und PmM den Zugang zu Gesundheitsleistungen zu erleichtern.
Diversität im Hochschulkontext – und das Desiderat eines diskriminierungskritischen Gesundheitsverständnisses
Authors: Satilmis Ayla 
Published: February 2024

Zusammenfassung
Im Bildungsbereich steht „Vielfalt“ seit einem halben Jahrhundert auf der Agenda. In den Hochschuldiskurs hat der Topos jedoch erst deutlich später Eingang gefunden. In diesem Beitrag geht es darum, das prädominante Diversitätsverständnis im Hochschulbereich nachzuzeichnen sowie Fallstricke mit Bezug auf Gesundheit zu skizzieren. Es wird eine intersektionale Perspektive vorgeschlagen, die Diversität im Kontext von Antidiskriminierung betrachtet und gesundheitliche Ungleichheiten vor dem Hintergrund von Diskriminierungsverhältnissen beleuchtet.
Gesundheitliche Ungleichheit und Bildungserfolg
Authors: Tuppat Julia 
Published: February 2024

Zusammenfassung
Der Beitrag beleuchtet die Relevanz gesundheitlicher Ungleichheit im Schulalter für den Bildungserwerb und intergenerationale soziale Mobilität. Es wird ein Überblick über Theorien und empirische Befunde zu der Annahme gegeben, dass Gesundheit eine bildungsrelevante Ressource darstellt. Aus Public Health Sicht dürfte die empirische Bestätigung der Relevanz von Gesundheit für Bildungsergebnisse dabei helfen, Schulen für die Teilnahme an gesundheitsfördernden Maßnahmen zu gewinnen.
Der Schutz vor Konversionsbehandlungen in der BZgA-Initiative LIEBESLEBEN
Authors: Breuer Johannes 
Published: February 2024

Zusammenfassung
Gesundheitsförderung muss queere Vielfalt berücksichtigen, um bestehende Gesundheitsrisiken abzubauen. Dazu dient der Schutz vor Konversionsbehandlungen als Beispiel, anhand dessen sich trotz gesetzlichen Verbots verschiedene Herausforderungen zeigen. Diese betreffen insbesondere die Unbekanntheit des Phänomens und die queerfeindliche Verwurzelung dieser Pseudotherapien. Mit LIEBESLEBEN, einer Initiative der BZgA, wird diesen Herausforderungen auf unterschiedliche Weise begegnet.
Kriterien für eine Public Health-Intervention – Ergebnisse eines Delphi-Prozesses
Authors: Niederberger Marlen , Dieudonné Jessica , Jantzen Lisa , Sanwald Michelle , Trompke Michaela 
Published: February 2024

Zusammenfassung
In einer Delphi-Studie wurden Expert*innen aus Wissenschaft und Praxis gebeten, sechs Kriterien für die Definition einer Public Health-Intervention (PHI) zu bewerten und zu konsentieren. Als relevant erweisen sich die Intention der Intervention, mögliche Interessenskonflikte von Initiator*innen der Intervention, ob es sich um eine Primär- versus Sekundär-/Tertiärprävention handelt und die Reichweite der Intervention. Im Dissens bleiben die Kriterien zur Relevanz der Kosten und Zielgenauigkeit der Intervention.
Single-cell analysis of Rohon-Beard neurons implicates Fgf signaling in axon maintenance and cell survival
Authors: Tuttle Adam M. , Miller Lauren N. , Royer Lindsey J. , Wen Hua , Kelly Jimmy J. , Calistri Nicholas L. , Heiser Laura M. , Nechiporuk Alex V. 
Published: February 2024

Peripheral sensory neurons are a critical part of the nervous system that transmit a multitude of sensory stimuli to the central nervous system. During larval and juvenile stages in zebrafish, this function is mediated by Rohon-Beard somatosensory neurons (RBs). RBs are optically accessible and amenable to experimental manipulation, making them a powerful system for mechanistic investigation of sensory neurons. Previous studies provided evidence that RBs fall into multiple subclasses; however, the number and molecular make up of these potential RB subtypes have not been well defined. Using a single-cell RNA sequencing (scRNA-seq) approach, we demonstrate that larval RBs in zebrafish of unknown sex fall into three, largely non-overlapping classes of neurons. We also show that RBs are molecularly distinct from trigeminal neurons in zebrafish. Cross-species transcriptional analysis indicates that one RB subclass is similar to a mammalian group of A-fiber sensory neurons. Another RB subclass is predicted to sense multiple modalities, including mechanical stimulation and chemical irritants. We leveraged our scRNA-seq data to determine that the fibroblast growth factor (Fgf) pathway is active in RBs. Pharmacological and genetic inhibition of this pathway led to defects in axon maintenance and RB cell death. Moreover, this can be phenocopied by treatment with dovitinib, an FDA-approved Fgf inhibitor with a common side effect of peripheral neuropathy. Importantly, dovitinib-mediated axon loss can be suppressed by loss of Sarm1, a positive regulator of neuronal cell death and axonal injury. This offers a molecular target for future clinical intervention to fight neurotoxic effects of this drug.SIGNIFICANCE STATEMENTElucidating the signaling pathways and cellular mechanisms that regulate sensory neuron health and maintenance is critical for understanding neuropathy etiologies and exploring therapies. Rohon-Beard (RB) sensory neurons are an accessible in vivo model to explore neurobiological mechanisms of such neuropathies. However, the number and nature of Rohon-Beard subpopulations have not been fully explored. We demonstrate that there are three subpopulations of RBs with unique transcriptional profiles. Furthermore, we find Fgf signaling has a novel role in survival and axonal maintenance of RBs. Our work finds a new molecular pathway for the maintenance of sensory axons and provides the first transcriptionally-based classification of RB neurons. It also sets the stage to explore how Fgf signaling may be involved in peripheral neuropathies.
Hematohidrosis in Pediatric Practice – a Case Report and Review of the Literature
Authors: Matsyura Oksana , Besh Lesya , Jefimova Svitlana , Slivinska-Kurchak Khrystyna , Gerasymov Sergiy 
Published: February 2024

Hematohidrosis (bloody sweat) is a symptom of trophic damage to the vascular wall, in which sweat mixes with blood and seeps onto undamaged areas of the skin in the form of red or pink liquid (depending on the ratio of sweat to blood). In our study we have analyzed 25 case reports of hematohidrosis in children, reported throughout the world using PubMed, ResearchGate with detailed description and opened access. We took into consideration: age of the patient, sex, location of bloody excretion, cause or trigger, treatment and its effectiveness.Our clinical case present a 9-year-old girl complained of a periodic bleeding from the intact skin of the face, neck, thighs (without visible damage to the skin) manifested by red or pink liquid, nosebleeds, and bloody discharge from the mucous membrane of the eyes. The secretions were of varying intensity and lasted up to several hours. Most of all episodes are associated with a strong emotional exertion. One of the theories of hematohidrosis pathogenesis is evident vasoconstriction of the blood vessels surrounding the sweat glands, provoked by hyperactivation of the sympathetic nervous system, which is followed by their excessive vasodilation up to rupture and blood entering the sweat gland ducts. Capillary endothelial cells are known to contain β2-adrenoceptors, which, through the modulation of nitric oxide release, cause endothelium-dependent vasodilation. Blocking β-adrenoceptors (for example, propranolol) prevents excessive vasodilation of blood vessels and, accordingly, their rupture and blood flow to the sweat gland.We managed to find out that the patient’s bloody sweat was a manifestation of a separate pathological phenomenon, and not one of the symptoms of another disease. A properly formed treatment complex and the great trust of the parents enabled to stabilize the child’s condition, and later to cure her. Currently, hematohidrosis is recognized as an independent disease that requires in-depth study of the triggering mechanisms of development, pathogenetic and clinical features.
EMPODERAMIENTO DEL LÍDERES COMUNALES DEL MUNICIPIO DE SOACHA, PARA LA GESTIÓN DE PROYECTOS DE INVERSIÓN SOCIAL
Authors: Mendez Suarez Marleny , Morera Galindo Maria del Pilar , Castro Rey Maria Estella , Mican Melo Henry Leonel 
Published: February 2024

La OCDE (Rodríguez, 2016) en las recomendaciones sobre Inversión Pública Eficiente entre los niveles de gobierno requiere Involucrar grupos de interés públicos, privados y de la sociedad civil en todo el ciclo de inversión.
En Colombia, los líderes comunales presidentes de las juntas administradoras locales y juntas de acción comunal son los encargados de velar por los intereses de su comunidad, además son quienes conocen por su propia experiencia o por comunicación de sus vecinos, la dimensión de las problemáticas y de las consecuencias que estas generan. Por tanto, son los primeros llamados a conformar los equipos de trabajo que propongan soluciones pertinentes y eficientes.
La inversión en Colombia debiese tener una fuerte dimensión territorial que considere las distintas necesidades y desafíos de las distintas localidades. La infraestructura y una mejor conectividad pueden servir para que las regiones rezagadas converjan y mejoren su desempeño, y simultáneamente mejoren también otros factores clave para el crecimiento, en especial el capital humano (OCDE, 2009).
Improvement of Motor Skills and Motivation to Learn Physical Education Through the Use of Traditional Games
Authors: Aliriad Hilmy , Adi S  , Manullang Jujur Gunawan , Endrawan I Bagus , Satria M. Haris 
Published: February 2024

Study purpose. This study aims to investigate motor skills and motivation to learn physical education through traditional games.
Materials and methods. The study was conducted using an experimental method and involved 60 students from primary schools in Purwodadi District, Grobogan Regency, Indonesia. Data were collected by measuring motor skills and learning motivation through affective, cognitive and psychomotor tests that were examined for validity and reliability. In addition, students’ character was also measured through observational tests of students’ basic movement skills. The measurement of basic movement skills was carried out before and after the intervention, which lasted for 8 sessions over one month. Data analysis was carried out using the ANOVA technique, reinforced by regression of research results using SPSS 22 software.
Results. The results showed that the traditional game approach had a significant effect on increasing students’ motivation to learn physical education. The traditional games approach also contributed positively to students’ learning outcomes. Through hands-on experience in these traditional games, students can develop motor skills, coordination, speed, strength, as well as cognitive aspects such as strategy, spatial intelligence and situation analysis.
Conclusions. By participating in traditional games, students can understand and respect cultural heritage and broaden their horizons about cultural diversity. Suggestions for future investigations include extending the research and development activities by including a larger sample, which may provide greater statistical power to support research findings in the area of traditional games.