bluuebunny/crossref_metadata_2025_split huggingface dataset:
Malignant smooth muscle tumors of the retroperitoneum and mesentery: A clinicopathologic analysis of 44 cases
Authors: Hashimoto Hiroshi , Tsuneyoshi Masazumi , Enjoji Munetomo 
Published: February 2007

AbstractForty‐four cases of leiomyosarcoma arising in the retroperitoneum (33 cases) and mesentery (11 cases) were analyzed clinicopathologically, and four were examined ultrastructurally. These tumors were more common in women (61 %) than in men (39%), and the median age of the patients was 59 years. Except for three tumors, most were large and over 10 cm in the greatest diameter. Twenty‐seven tumors were classical leiomyosar‐comas, while seven were composed predominantly of epithelioid cells and classified as malignant leiomyoblastoma (epithelioid leiomyosarcoma). In addition to the classical microscopic features, dedifferentiated areas resembling malignant fibrous histiocytoma were noted in three cases. Ultrastructurally, the tumors were characterized by smooth muscle tumor cells showing a spectrum of differentiation of varying degrees. Of the 42 patients for whom follow‐up information could be obtained, 33 (79%) died within a period of five years after the initial treatment. Mitotic activity showed no significant correlation with biological behavior; ten of the 15 patients in whom the mitotic counts were less than five per 10 high‐power fields (HPF), expired of the tumor.
High incidence of liver metastasis in gastric cancer with medullary growth pattern
Authors: Kaibara Nobuaki , Kimura Osamu , Nishidoi Hideaki , Makino Masato , Kawasumi Hiroki , Koga Shigemasa 
Published: February 2007

AbstractWe studied the histology of resected specimens from 71 gastric cancer patients with synchronous and metachronous liver metastasis to assess the predominance of a particular histological pattern in gastric cancer with a tendency for liver metastasis. Poorly differentiated adenocarcinoma manifesting a medullary growth pattern was the most frequent histologic pattern (33%), followed by papillary adenocarcinoma (28%) in 39 patients with synchronous liver metastasis. In 32 patients who developed metachronous liver metastasis as the main pattern of recurrence, papillary adenocarcinoma was most frequent (47%), followed by poorly differentiated adenocarcinoma of the medullary type (28%). Scirrhous carcinoma was not encountered in patients manifesting metachronous liver metastasis. As most of the papillary adenocarcinomas exhibited a medullary growth pattern, we hypothesize that gastric cancer of the medullary type tends to metastasize to the liver, irrespective of the basic histologic pattern, and that poorly differentiated adenocarcinoma of the medullary type has a particularly high tendency for metastasizing to the liver.
Hormonal evaluation in patients with osteosarcoma
Authors: Vassilopoulou‐Sellin Rena , Wallis Christopher J. , Samaan Naguib A. 
Published: February 2007

AbstractAspects of growth regulation were studied in patients with osteosarcoma to ascertain if hormonal imbalance is associated with this disease. Thirty‐nine evaluated patients were of normal height for their ages. During the oral glucose tolerance test, carbohydrate intolerance was demonstrated in seven of 18 patients, while growth hormone was slightly elevated in four of 17 patients. Serum somatomedin activity (SMA) was elevated in seven of nine patients. In one untreated patient in whom SMA was measured across the tumor bed, significant gradient of SMA was found; gel filtration of the sera at pH 2.4 revealed a typical SMA profile in the arterial serum and an additional high SMA peak in the venous serum. Among needle biopsy specimens incubated for 48 hours. SMA was released by the histologically viable tumors but not by the nonviable specimens. The data suggest that young patients with osteosarcoma have elevated SMA.
The effects of hyperthermia on vascular permeability in experimental liver metastasis
Authors: Lefor Alan T. , Makohon Stefania , Ackerman Norman B. 
Published: February 2007

AbstractThe effects of hyperthermia on vascular permeability in Walker carcino‐sarcomas and host liver tissue were studied in Sprague‐Dawley rats. A quantitative Evans blue technique was used to measure permeability. With tumors heated to 40° C, a nontherapeutic level, no changes in tumor vascular permeability as compared to control levels were noted. However, with tumors heated to 43° C, within the therapeutic range of hyperthermia, significant rises in tumor vascular permeability occurred. Permeability was increased at both time periods studied, 30 minutes and 6 hours after hyperthermia and injection of Evans blue. These changes are similar to those seen after physical damage from freeze‐thaw. It is likely that alterations in tumor microcirculation play a role in the therapeutic effect of intense hyperthermia.
Intravesical chemotherapy of superficial bladder tumors in a controlled trial with cis‐platinum versus Cis‐platinum plus hyaluronidase
Authors: Horn Yoav , Eidelman Avraham , Walach Natalio , Waron Mordechai , Barak Frida 
Published: February 2007

AbstractTwenty‐three patients with superficial transitional cell carcinoma of the urinary bladder were randomized for intravesical chemotherapy with either cis‐platinum or cis‐platinum plus hyaluronidase, an enzyme promoting diffusion factor. Treatment was administered at 3‐week intervals and checked for efficacy by repeated cystoscopies after every three instillations. Hematologic and biochemical tests were repeated prior to each treatment and, these, in additional to the cystoscopic findings, served for final evaluation of results and toxicity. The complete response rate was found to be superior with cis‐platinum than with cis‐platinum plus hyaluronidase. The complete plus partial response rates were equal in both groups. We conclude that the addition of hyaluronidase to cis‐platinum revealed no superiority to cis‐platinum alone, and both modes of treatment showed similar clinical efficacy as other drugs previously used for intravesical chemotherapy.
Acute leukaemia following malignant ependymoma: A case report
Authors: Pai M. R. S. M. , Advani S. H. , Gopal R. , Nair C. N. , Saikia T. , Kamat D. M. 
Published: February 2007

AbstractThough an increasing number of chemotherapy‐ and radiotherapy‐related leukaemias are being reported, acute promyclocytic leukaemia developing as a therapy‐related second malignancy is still uncommon. Here we report a case of acute promyetocytic leukemia, microgranular variant, developing in a case of intracranial malignant ependymoma, 1.5 years following treatment with craniospinal radiotherapy.
Altered characteristics of B16 melanoma cells induced by chemically crosslinking fibronectin to cell surfaces
Authors: Bowersox Jon C. , Richters Arnis , Sorgente Nino 
Published: February 2007

AbstractThe loss of fibronectin from tumor cell surfaces has been correlated with an increased incidence of metastases. To determine directly whether cell surface fibronectin influences the metastatic potential of solid tumors, we chemically crosslinked fibronectin to B16 murine melanoma cells using a photosensitive heterobifunctional crosslinking reagent, N‐succinimidyl‐4‐azidophenyl‐1,3 dithiopropionate (SADP). Cell attachment to plastic surfaces was increased in cells to which fibronectin was attached; cell growth over a 24‐hr period was not significantly affected by the addition of fibronectin. When C57BL/6 mice were injected with fibronectin‐cross‐linked B16 cells, there was a 63% reduction in the number of pulmonary nodules compared to untreated controls. These results are consistent with the hypothesis that fibronectin enhances the recognition and removal of tumor cells from the circulation, possibly by cells of the reticuloendothelial system.
Value of liver scintigraphy in pretreatment staging and in follow‐up of patients with malignant melanoma
Authors: Jönsson Per‐Ebbe , Hafström Larsolof , Hugander Anders , Cederquist Ebbe 
Published: February 2007

AbstractLiver scintigraphy (99Tcm sulphur colloid) was performed in 118 patients with malignant melanoma. In 73 patients diagnosed as stage I, the pretreatment evaluation showed one false‐negative and one false‐positive examination. During follow‐up there were ten abnormal liver scintigraphies; one was later correlated to liver metastases. In 46 patients diagnosed as stage II‐IV, the pretreatment liver scintigraphy yielded false‐negative results in 36% and false‐positive results in 15%. The predictive values of positive and negative tests were 44% and 81%, respectively. The yields of liver tests (S‐alkaline phosphatase, S‐gamma‐glutamyl‐transferase) in patients with liver metastases were low. This study demonstrated the limitations of liver scintigraphy for diagnosis of liver metastases in patients with malignant melanoma.
Squamous metaplasia in colonic adenomata: Report of two cases
Authors: Kontozoglou Theodosios 
Published: February 2007

AbstractTwo cases of squamous metaplasia in colonic adenomata are reported. Since squamous metaplasia is known to occur rarely in the colon it is surprising that its occurrence in colonic adenomata has not been emphasized; this is more remarkable as its presence may have clinical significance as a precursor of rare forms of carcinoma of the colon.
Histopathologic effect of preoperative chemotherapy using 5‐Fu fat emulsion in gastric cancer
Authors: Wu Yong‐Fang , Zhen Zhuan‐An , Shao Jia‐Kang , Zhen Hong‐De , Han Zhi‐Hong 
Published: February 2007

AbstractThe authors report histopathologic effect of preoperative chemotherapy using 5‐Fu fat emulsion for a series of 42 cases of gastric carcinoma. To each patient 348–464 mg of 5‐Fu emulsion was given orally every day for 10 days before operation. It was well tolerated and no apparent side‐effects were encountered. The overall response rate was 57.14%. We hold that this regimen is beneficial for gastric cancer.
Technical developments and instrumentation: Percutaneous transhepatic feeding jejunostomy
Authors: Haskell Liliana , Gordon Roy L. , Salomonowitz Erich , Ayalon Amram , Durst Arieh 
Published: February 2007

AbstractA new access route for insertion of a feeding jejunostomy using a percutaneous transhepatic approach is described in a case with advanced antral cancer. Standard PTC techniques and angiographic catheters were used.
Beta‐2‐microglobulin as a marker of malignant epithelial tumors of the skin
Authors: Sarma Deba P. , Olivier Maureen , Goldsman Cary , Millikan Larry E. 
Published: February 2007

AbstractTwenty‐seven formalin‐fixed, paraffin‐embedded skin samples were examined to determine the usefulness of the loss of beta‐2‐microglobulin (B2m) in determining the malignancy of the epithelial cells of skin tumors. Our results confirm that there is loss of B2m from the cell surface in certain malignant lesions whereas the cells in the clearly benign lesions retain B2m on their cell membrane. Variable staining in the low‐grade malignant and premalignant lesions renders B2m as an unreliable cell surface marker for differentiating borderline lesions.
Effects of intralymphatic immunotherapy on natural killer activity in malignant melanoma patients
Authors: Moy Peter M. , Golub Sidney H. , Calkins Edward , Morton Donald L. 
Published: February 2007

AbstractAdjuvant immunotherapy has the theoretical attraction of augmenting the host immune response at a time when the tumor burden is low. We have previously reported that intralymphatic immunotherapy (ILI) augments the cytolytic humoral immune responses in melanoma patients. This study was undertaken to assess the effects of ILI on cell‐mediated immunity. As a model for the cellular effects of ILI, we investigated the natural killer (NK) cell activity in malignant melanoma patients. Fourteen patients were given an allogeneic cultured tumor cell vaccine (TCV) intralymphatically with concomitant administration of BCG. Natural killer cell activity was assessed sequentially using the single cell lysis and binding assay. Overall NK activity against the K562 target cell line showed a moderate increase over pretreatment levels as reflected by the increased number of target binding lymphocytes. However, the percentage of target binders mediating cell lysis remained unchanged during treatment. Assessment of NK activity against the NK‐resistant M14 melanoma cell line reflected similar findings. These results suggest the activation of NK cells by tumor antigens, BCG, and/or alloimmunization with TCV. This increase appears to be manifested by increased target recognition rather than by alterations in effector cell function.
Spontaneous rupture of hepatocellular carcinoma
Authors: Van Landingham Samuel B. , Hendricks John C. , Roberts John W. 
Published: February 2007

AbstractSpontaneous rupture of a primary hepatocellular carcinoma is an extremely rare event in the western hemisphere. Only a handful of singlecase reports have been authored in the continental United States. A ruptured hepatoma carries a dismal prognosis and is usually beyond a “resection for cure” stage. In this report, two cases of spontaneously ruptured primary hepatocellular carcinoma are described. Both cases involved cirrhotic livers, and the tumor in each case was resected to attempt cure. One patient survived nearly 2 years; the other is alive and well at this time.
The response to further chemotherapy in patients with carcinoma of the breast who progressed while receiving adjuvant therapy
Authors: Morris Don M. , Elias E. George , Didolkar Mukund S. , Brown Sally D. 
Published: February 2007

AbstractThe effect of known chemotherapeutic programs in patints with breast cancer who developed metastasis during or after adjuvant chemotherapy with L‐PAM plus 5‐FU (PF) were switched. Thirteen patients failed while receiving adjuvant therapy at 3–22 months from the time therapy started. Three patients failed 6–28 months after 2 year of therapy. Thirteen patients received PF followed by cyclophosphamide, methotrexate, and 5‐fluorouracil (CMF) at the time of progression PF. Of these, ten received Adriamycin and vincristine (AV) at the time of progression on CMF. The response to CMF was 7%. No patint responded to AV after progression on CMF. Two of three patients treated with AV after failure on PF did respond, but both for only 6 responsive to further chemotherapy. Sine most patients failed while on adjuvant therapy, this may indicate a poor prognosis regardless of the agents used.
Primary mediastinal germinomas in females: A case report and review of the literature
Authors: Moriconi William J. , Taylor Sarah , Huntrakoon Manop , MacArthur Richard I. , Bixler Thomas J. 
Published: February 2007

AbstractPrimary mediastinal germinomas in females are rare. Long‐term survival ranges from 50 to 81%, depending on the initial extent of disease. Initial spread occurs intrathoracically and to regional nodes with late hematogenous dissemination. The roles of surgery, radiation therapy, and chemotherapy are discussed.
Hepatic tumors and oral contraceptives: Surgical management
Authors: Gonzalez Federico , Marks Charles 
Published: February 2007

AbstractThe clinical and pathological features of 14 patients with benign liver tumors are reviewed. There were two males and 12 females in this series of cases. All but one of the females had been on contraceptive steroid therapy for an average of 7.8 years. Abdominal pain was the presenting complaint in 75% of cases, a palpable abdominal mass was present in 22%, while 12.5% of the patients presented with acute hemorrhagic shock due to rupture of a liver cell adenoma. Liver cell adenomas (LCA) were found in 87.5% of the cases and a diagnosis of focal nodular hyperplasia (FNA) was made at histologic examination of the resected tumors in 12.5% of cases.Surgical resection of the liver tumors was performed successfully in 89% of the cases. Hepatic lobectomy was accomplished in four patients, hepatic segmentectomy was possible in three cases, while local wedge resection or focal excision were indicated on seven occasions. There was no operative mortality in this series, but one patient required reoperation for drainage of a complicating subphrenic abscess.
Therapeutic advantage in preoperative single‐dose radiation combined with conservative and radical surgery in different‐size murine fibrosarcomas
Authors: Todoroki Takeshi , Suit Herman D. 
Published: February 2007

AbstractThe efficacy of surgery alone or combined with preoperative radiation was examined using isotransplants of the spontaneous fibrosarcoma (FSaII) growing in the right leg of syngeneic C3Hf/Sed mice and employing as end‐points both local tumor control probability and normal tissue damage. Complete assays have been performed on small (4–5 mm) and large (8 mm) tumors. The TCD50s (the dose required to control half the irradiated tumors) for radiation alone were 63.2 and 82.7 Gy for small and large tumors, respectively. Surgery was performed 4 days after the radiation treatment. Surgical resections were performed under an 8X dissecting microscope. In small tumors, radical (enbloc resection) and conservative (local resection) surgery alone achieved 69.8% (30/43) and 21.9% (7/32) tumor control. The corresponding figures for large tumor were 25% (8/32) and 6.1% (2/33), respectively. The combination of radiation and surgery increased tumor control frequency up to 100% with doses lower than TCD50 for radiation alone. The TGF is expresseed as therapeutic gain factor for conservative and for radical surgery for 4–5‐mm and for 8‐mm tumors from analyses of dose response curves for tumor control and leg shortening. In small tumors, the TGFs at the 80% tumor control (TCD80) and leg shortening of 5 mm were 1.4 and 1.8 for radical and conservative resection, respectively. The TGFs at the TCD50 level for large tumors were 1.4 and 1.7 in respective resections. In this particular experimental system, conservative surgery yielded higher TGFs than radical surgery for both tumor sizes. No effect of preoperative treatment on the frequency of distant metastasis was observed.
Multiple primary cancers of the respiratory tract: A case of synchronous carcinoma of the larynx, carcinoma of the floor of the mouth, and dual primary bronchogenic carcinomas
Authors: Staren Edgar D. , Roberts Jack 
Published: February 2007

AbstractMultiple primary cancers of the respiratory tract are no longer considered uncommon. We describe a patient with synchronous carcinoma of the larynx, carcinoma of the floor of the mouth, and dual primary bronchogenic carcinomas. The clinical presentation, course, and treatment of this condition are discussed. Clinicians should be aware that multiple primary cancers of the respiratory tract are being reported more frequently and any tumor of this area demands a detailed examination of the entire tract at the time of diagnosis and careful, regular follow‐up.
Nutritional status in advanced upper gastrointestinal cancer
Authors: Singh Gurpreet , Khanna N. N. 
Published: February 2007

AbstractFifty‐four patients with advanced upper gastrointestinal cancer were assessed for their nutritional status prior to any form of therapy. Anthropometric parameters—weight loss, arm muscle circumference, skin‐fold thickness—and biochemical parameters—serum albumin and delayed cutaneous hypersensitivity reactions to purified protein derivative (PPD) and phytohemagglutinin (PHA)—were used for nutritional assessment. Using standard values for comparison, about 80% of all patients were found to be nutritionally depleted. Immunocompetence did not show significant correlation with other nutritional parameters.
Unusual faces of lung cancer
Authors: Sapone Frances M. , Reyes Cesar V. 
Published: February 2007

AbstractLung cancer is the leading cause of death from malignancy in men; and prediction indicates that in women it will soon surpass breast carcinoma in incidence and mortality. Four unusual modes of presentation of lung cancer are described, namely: ascites, gynecomastia, rectal bleeding, and sudden death. An illustrative case for each characteristic, along with a brief literature review, is reported.
The effect of age on estrogen and progesterone receptor in primary breast cancer
Authors: Alghanem A. A. , Hussain S. 
Published: February 2007

AbstractWe evaluated the estrogen receptors (Er) and progesterone receptors (Pr) in 228 female patients with primary breast cancer by Dextran‐Charcol method. Their ages vary from 30 to 91 years. Mean age 60.7 years. (SD: 13.6 years). Er mean was 70.31. (SD:103); there exists a statistically significant correlation between age and Er at p< .001; older patients have higher Er. Pr mean was 60.73, (SD:128). There is statistically significant correlation between age and Pr at .01 p<.025; older patients have higher Pr. There is also very statistical significant correlation between Er and Pr at p<0.1; when Er is high Pr is high.
Antitumor effect in peritoneal carcinomatosis of intraperitoneal administration of a streptococcal preparation, OK‐432: I. Experimental study in the rat
Authors: Saji Shigetoyo , Umemoto Takao , Kida Hisashi , Sakata Kazuki 
Published: February 2007

AbstractThe effect of intraperitoneal OK‐432 administration and its mechanism of action were investigated using an experimental rat tumor. On day 4 or 6 of intraperitoneal inoculation of tumor cells, 50 Klinische Einheit (KE)/kg of OK‐432 was intraperitoneally administered, and intraperitoneal exudate cells were microscopically examined daily. Distribution of peritoneal exudate cells: A marked increse in neutrophils was noted in ascites at 24 hours after intraperitoneal administration of OK‐432, with macrophages and lymphocytes appearing later than neutrophils. A subsequent decrease in neutrophils was accompanied by a gradual increase in tumor cells. Findings of tumor cells: When OK‐432 was intraperitoneally administered on day 4 of tumor inoculation, aggregation of neutrophils around tumor cells was observed on day 6, and rosette formations around tumor cells were noted on day 7 or 8. Subsequently tumor cells that formed the centers of the rosettes were destroyed and disappeared. These reactions were not observed when OK‐432 was administered on day 6, nor were they observed in untreated cases. These results suggest that cytotoxic effects of intraperitoneally administered OK‐432 were displayed mainly by rosette formation by neutrophilic cells, as far as this model was concerned.
Primary orbital lymphoma—pseudotumor (pseudolymphoma): Case reports and review of radiotherapy literature
Authors: Ampil Federico L. , Bahrassa Feraydoon S. 
Published: February 2007

AbstractFive case reports of orbital pseudotumor (pseudolymphoma) and primary orbital lymphoma are presented. A review of the literature was conducted in search of differentiating clinic opathologic features suggestive of either condition as well as part of their natural histories. Radiotherapy series reporting beneficial results are summarized.
Bilateral breast cancer
Authors: Michowitz Moshe , Noy Shlomo , Lazebnik Noam , Aladjem David 
Published: February 2007

AbstractBetween the years 1972 and 1982, 1,880 women were treated for breast cancer at the Tel‐Aviv Medical Center. One thousand two hundred fifteen detailed charts are included in our study. Sixty‐six patients (5.4%) were diagnosed as having bilateral breast cancer. The mean age at first tumor diagnosis was 55.1 years. Bilateral breast cancer appears to be more common in nulligravidas and women who have delivered up to two children. In patients where the first tumor was greater than 4 cm in diameter, there was a higher incidence of a second tumor. A total of 65.2% of all patients who developed a second breast tumor had no axillary lymph node metastasis at the time the first breast tumor was diagnosed. There was no correlation between the histological types of the first and second tumors. The longer the woman survived after the first cancer diagnosis, the greater the likelihood of her developing a second tumor; the longer the interval between the diagnosis of the two cancers, the better the survival rate.