bluuebunny/crossref_metadata_2025_split huggingface dataset:
A comparison of the transradial and the transfemoral approach in chronic total occlusion percutaneous coronary intervention
Authors: Rathore Sudhir , Hakeem Abdul , Pauriah Maheshwar , Roberts Elved , Beaumont Andrew , Morris John L. 
Published: December 2008

AbstractBackground: Transradial coronary intervention is a safe and effective method of percutaneous revascularization. Furthermore, the indications for transradial percutaneous coronary intervention (PCI) are expanding. However, there is limited data on the efficacy and the safety of the transradial approach for chronic total occlusion (CTO) PCI. Methods: We examined 468 patients who underwent CTO PCI between January 2003 and December 2005, and compared the radial (318 patients) and the femoral (150 patients) approach. Results: Baseline demographics, lesion location, and the vessel treated were similar in both groups. Angiographic success was 82% in radial versus 86% in femoral group, P = 0.28, similar in both groups. Total fluoroscopy time (24.49 ± 13.18 vs. 24.07 ± 14.12 min, P = 0.36), total procedure time (54.22 ± 25.35 vs. 60.23 ± 28.15 min, P = 0.23), and the use of total contrast volume (395.54 ± 180.25 vs. 406.15 ± 173.98 ml, P = 0.27) were similar in radial and femoral group, respectively. In hospital MACE [radial: 12 MI (3.8%) vs. femoral: 1 death (0.7%) and 5 MI (3.5%), P = 0.26] were similar in both groups. Access site vascular complications [radial: 11 (3.5%) vs. femoral: 17 (11.3%), P ≤ 0.001] were significantly less in radial group. Conclusions: The radial approach in CTO PCI is as fast and successful as the femoral approach with comparable in hospital MACE. However, there are far less access site complications with radial approach. © 2008 Wiley‐Liss, Inc.
Covered Cheatham‐Platinum stents for serial dilation of severe native aortic coarctation
Authors: Bruckheimer Elchanan , Dagan Tamir , Amir Gabriel , Birk Einat 
Published: December 2008

AbstractObjectives: To report on the early results of treatment of native coarctation of the aorta by implantation and serial dilations of covered stents. Background: Transcatheter dilation of native coarctation of the aorta carries a risk of aneurysm or rupture. Covered stent implantation requires a large delivery system with the risk of vascular damage. Methods: Covered stents on balloons of diameter sufficient to anchor the stent in the coarctation were implanted using the smallest delivery system possible. Dilation with larger diameter balloons was performed until the pressure gradient was <20 mm Hg and the stent was opposed to the aortic wall. Results: Twenty‐two patients with native coarctation underwent stent implantation. Coarctation diameter increased from 3.6 ± 1.9 to 12.6 ± 1.9 mm (P < 0.001). Peak pressure gradient decreased from 29.4 ± 8.5 to 6.7 ± 5.7 mm Hg (P < 0.001). Nine patients underwent further dilation on average 5 months later. Residual pressure gradient decreased from 12.3 ± 5.8 to 2.1 ± 2.9 mm Hg (P = 0.002). The stent achieved the diameter of the transverse arch in all cases. Complications included a small tear at further dilation treated with a second stent and a femoral pseudoaneurysm. At short‐term follow‐up of 18.5 months all patients are alive and well with no evidence of recoarctation or aneurysm. Conclusions: These initial results show that serial dilation of covered Cheatham‐Platinum stents is feasible, safe, and an effective percutaneous method for the treatment of native coarctation of the aorta. However, long‐term follow up is required. © 2009 Wiley‐Liss, Inc.
Delayed and repeated cardiac tamponade following microleak in RCA successfully treated with intra arterial sterile glue injection
Authors: Goel Pravin K. 
Published: December 2008

AbstractPostinterventional pericardial leaks mostly occur intraprocedure or immediately postprocedure and call for an aggressive management right then. Also, once controlled for 24–48 hr, the leaks usually seal themselves spontaneously. We herein describe an unusual case of delayed and continued pericardial leak over 10 days as a result of micro perforation of RCA from the distal wire tip and which was successfully managed by intracoronary injection of sterile synthetic glue, which to the best of our knowledge is the first report of its kind. © 2009 Wiley‐Liss, Inc.
Intermolecular Olefin Functionalisation Involving Aryl Radicals Generated from Arenediazonium Salts
Authors: Heinrich Markus R. 
Published: December 2008

AbstractThis minireview is aimed at giving an overview of recent advances in olefin functionalisation reactions involving aryl radicals generated from arenediazonium salts. Based on the well‐known Meerwein arylation, in which an aryl and a halogen substituent are coupled to an olefinic substrate, new reaction types have been developed that allow the introduction of a broad spectrum of other atoms and functional groups at the place of the original halogen atom and that are applicable to an extended range of olefinic substrates.
Heterogeneous Versus Homogeneous Palladium Catalysts for Ligandless Mizoroki–Heck Reactions: A Comparison of Batch/Microwave and Continuous‐Flow Processing
Authors: Glasnov Toma N. , Findenig Silvia , Kappe C. Oliver 
Published: December 2008

AbstractMizoroki–Heck couplings of aryl iodides and bromides with butyl acrylate were investigated as model systems to perform transition‐metal‐catalyzed transformations in continuous‐flow mode. As a suitable ligandless catalyst system for the Mizoroki–Heck couplings both heterogeneous and homogeneous Pd catalysts (Pd/C and Pd acetate) were considered. In batch mode, full conversion with excellent selectivity for coupling was achieved applying high‐temperature microwave conditions with Pd levels as low as 10−3 mol %. In continuous‐flow mode with Pd/C as a catalyst, significant Pd leaching from the heterogeneous catalyst was observed as these Mizoroki–Heck couplings proceed by a homogeneous mechanism involving soluble Pd colloids/nanoparticles. By applying low levels of Pd acetate as homogeneous Pd precatalyst, successful continuous‐flow Mizoroki–Heck transformations were performed in a high‐temperature/pressure flow reactor. For both aryl iodides and bromides, high isolated product yields of the cinnamic esters were obtained. Mechanistic issues involving the Pd‐catalyzed Mizoroki–Heck reactions are discussed.
Early steps in the assembly of photoreceptor ribbon synapses in the mouse retina: The involvement of precursor spheres
Authors: Regus‐Leidig Hanna , tom Dieck Susanne , Specht Dana , Meyer Lars , Brandstätter Johann Helmut 
Published: December 2008

AbstractThe retinal photoreceptor ribbon synapse is a chemical synapse structurally and functionally specialized for the tonic release of neurotransmitter. It is characterized by the presynaptic ribbon, an electron‐dense organelle at the active zone covered by hundreds of synaptic vesicles. In conventional synapses, dense‐core transport vesicles carrying a set of active zone proteins are implicated in early steps of synapse formation. In photoreceptor ribbon synapses, synaptic spheres are suggested to be involved in ribbon synapse assembly, but nothing is known about the molecular composition of these organelles. With light, electron, and stimulated emission depletion microscopy and immunocytochemistry, we investigated a series of presynaptic proteins during photoreceptor synaptogenesis. The cytomatrix proteins Bassoon, Piccolo, RIBEYE, and RIM1 appear early in synaptogenesis. They are transported in nonmembranous, electron‐dense, spherical transport units, which we called precursor spheres, to the future presynaptic site. Other presynaptic proteins, i.e., Munc13, CAST1, RIM2, and an L‐type Ca2+ channel α1 subunit are not associated with the precursor spheres. They cluster directly at the active zone some time after the first set of cytomatrix proteins has arrived. By quantitative electron microscopy, we found an inverse correlation between the numbers of spheres and synaptic ribbons in the postnatally developing photoreceptor synaptic terminals. From these results, we suggest that the precursor spheres are the transport units for proteins of the photoreceptor ribbon compartment and are involved in the assembly of mature synaptic ribbons. J. Comp. Neurol. 512:814–824, 2009. © 2008 Wiley‐Liss, Inc.
Development of glycine immunoreactivity in the brain of the sea lamprey: Comparison with γ‐aminobutyric acid immunoreactivity
Authors: Villar‐Cerviño Verona , Barreiro‐Iglesias Antón , Anadón Ramón , Rodicio María Celina 
Published: December 2008

AbstractThe development of glycine immunoreactivity in the brain of the sea lamprey was studied by use of immunofluorescence techniques at embryonic to larval stages. Glycine distribution was also compared with that of γ‐aminobutyric acid (GABA) by use of double immunofluorescence. The first glycine‐immunoreactive (ir) cells appeared in the caudal rhombencephalon of late embryos, diencephalon of early prolarvae, and mesencephalon of late prolarvae, in which glycine‐ir cells were observed in several prosencephalic regions (preoptic nucleus, hypothalamus, ventral thalamus, dorsal thalamus, pretectum, and nucleus of the medial longitudinal fascicle), mesencephalon (M5), isthmus, and rhombencephalon. In larvae, glycine‐ir populations were observed in the olfactory bulbs, preoptic nucleus and thalamus (prosencephalon), M5 and oculomotor nucleus (mesencephalon), dorsal isthmic gray, isthmic reticular formation, and various alar and basal plate rhombencephalic populations. No glycine‐ir cells were observed in the larval optic tectum or torus semicircularis, which contain glycine‐ir populations in adults. A wide distribution of glycine‐ir fibers was observed, which suggests involvement of glycine in the function of most lamprey brain regions. Colocalization of GABA and glycine in prolarvae was found mainly in cell groups of the diencephalon, in the ventral isthmic group, and in trigeminal populations. In larvae, colocalization of GABA and glycine was principally observed in the M5 nucleus, the reticular formation, and the dorsal column nucleus. The present results reveal for the first time the complex developmental pattern of the glycinergic system in lamprey, including early glycine‐ir populations, populations transiently expressing glycine, and late‐appearing populations, in relation to maturation changes that occur during metamorphosis. J. Comp. Neurol. 512:747–767, 2009. © 2008 Wiley‐Liss, Inc.
Avian nucleus retroambigualis: Cell types and projections to other respiratory‐vocal nuclei in the brain of the zebra finch (Taeniopygia guttata)
Authors: Wild J.M. , Kubke M.F. , Mooney R. 
Published: December 2008

AbstractIn songbirds song production requires the intricate coordination of vocal and respiratory muscles under the executive influence of the telencephalon, as for speech in humans. In songbirds the site of this coordination is suspected to be the nucleus retroambigualis (RAm), because it contains premotor neurons projecting upon both vocal motoneurons and spinal motoneurons innervating expiratory muscles, and because it receives descending inputs from the telencephalic vocal control nucleus robustus archopallialis (RA). Here we used tract‐tracing techniques to provide a more comprehensive account of the projections of RAm and to identify the different populations of RAm neurons. We found that RAm comprises diverse projection neuron types, including: 1) bulbospinal neurons that project, primarily contralaterally, upon expiratory motoneurons; 2) a separate group of neurons that project, primarily ipsilaterally, upon vocal motoneurons in the tracheosyringeal part of the hypoglossal nucleus (XIIts); 3) neurons that project throughout the ipsilateral and contralateral RAm; 4) another group that sends reciprocal, ascending projections to all the brainstem sources of afferents to RAm, namely, nucleus parambigualis, the ventrolateral nucleus of the rostral medulla, nucleus infra‐olivarus superior, ventrolateral parabrachial nucleus, and dorsomedial nucleus of the intercollicular complex; and 5) a group of relatively large neurons that project their axons into the vagus nerve. Three morphological classes of RAm cells were identified by intracellular labeling, the dendritic arbors of which were confined to RAm, as defined by the terminal field of RA axons. Together the ascending and descending projections of RAm confirm its pivotal role in the mediation of respiratory‐vocal control. J. Comp. Neurol. 512:768–783, 2009. © 2008 Wiley‐Liss, Inc.
Paraventricular thalamic nucleus: Subcortical connections and innervation by serotonin, orexin, and corticotropin‐releasing hormone in macaque monkeys
Authors: Hsu David T. , Price Joseph L. 
Published: December 2008

AbstractThe present study examines subcortical connections of paraventricular thalamic nucleus (Pa) following small anterograde and retrograde tracer injections in cynomolgus monkeys (Macaca fascicularis). An anterograde tracer injection into the dorsal midline thalamus revealed strong projections to the accumbens nucleus, basal amygdala, lateral septum, and hypothalamus. Retrograde tracer injections into these areas labeled neurons specifically in Pa. Following a retrograde tracer injection into Pa, labeled neurons were found in the hypothalamus, dorsal raphe, and periaqueductal gray. Pa contained a remarkably high density of axons and axonal varicosities immunoreactive for serotonin (5‐HT) and orexin/hypocretin (ORX), as well as a moderate density of fibers immunoreactive for corticotropin‐releasing hormone (CRH). A retrograde tracer injection into Pa combined with immunohistochemistry demonstrated that ORX and 5‐HT axons originate from neurons in the hypothalamus and midbrain. Pa‐projecting neurons were localized in the same nuclei of the hypothalamus, amygdala, and midbrain as CRH neurons, although no double labeling was found. The connections of Pa and its innervation by 5‐HT, ORX, and CRH suggest that it may relay stress signals between the midbrain and hypothalamus with the accumbens nucleus, basal amygdala, and subgenual cortex as part of a circuit that manages stress and possibly stress‐related psychopathologies. J. Comp. Neurol. 512:825–848, 2009. © 2008 Wiley‐Liss, Inc.
Identification of Hydroxyl on Ni(111)
Authors: Shan Junjun , Kleyn Aart W. , Juurlink Ludo B. F. 
Published: December 2008

AbstractHydroxyl (OH) is identified and characterized on the Ni(111) surface by high‐resolution electron energy loss spectroscopy. We find clear evidence of stretching, bending, and translational modes that differ significantly from modes observed for H2O and O on Ni(111). Hydroxyl may be produced from water by two different methods. Annealing of water co‐adsorbed with atomic oxygen at 85 K to above 170 K leads to the formation of OH with simultaneous desorption of excess water. Pure water layers treated in the same fashion show no dissociation. However, the exposure of pure water to 20 eV electrons at temperatures below 120 K produces OH in the presence of adsorbed H2O. In combination with temperature‐programmed desorption studies, we show that the OH groups recombine between 180 and 240 K to form O and immediately desorbing H2O. The lack of influence of co‐adsorbed H2O at 85 K on the OH stretching mode indicates that OH does not participate in a hydrogen‐bonding network.
Targeting tumor vascular endothelium: an emerging concept for cancer therapy
Authors: Dhanabal Mohanraj , Karumanchi S. Ananth , Sukhatme Vikas P. 
Published: December 2008

AbstractAlthough traditional chemotherapeutic agents have saved thousands of lives over the years and delayed tumor progression, they have limited efficacy due to toxicity and lack of tumor cell selectivity. Recently some of the more promising anticancer therapy approaches tested and proven in clinical studies have used a combinatorial approach of using new molecularly targeted agents with standard therapies. In this regard, inhibition of angiogenesis represents a new approach to cancer therapy. To date, many anti‐angiogenic agents have been developed and are in different stages of clinical development. Targeting tumor cell‐associated endothelial cells may represent a potential powerful adjunct to traditional cancer therapy. In this review, we provide an overview of different approaches involved in discovery and development of anti‐angiogenic agents and discuss the clinical impact of these agents. Finally, we present and summarize some of the emerging concepts such as resistance to anti‐angiogenic drugs, anti‐angiogenic therapy‐related toxicity, and integrated treatment modalities. Drug Dev Res 69:340–351, 2008. © 2008 Wiley‐Liss, Inc.
Summary of ‘Interventions for the interruption or reduction of the spread of respiratory viruses’
Authors: Milne Andrea 
Published: December 2008

AbstractThis is a summary of a Cochrane review, published in this issue of EBCH, first published as: Jefferson T, Foxlee R, Del Mar C, Dooley L, Ferroni E, Hewak B, Prabhala A, Nair S, Rivetti A. Interventions for the interruption or reduction of the spread of respiratory viruses. Cochrane Database of Systematic Reviews 2007, Issue 4. Art. No.: CD006207. DOI: 10.1002/14651858.CD006207.pub2.Further information for this Cochrane review is available in this issue of EBCH in the accompanying Commentary and Characteristics and Key Findings Tables. Copyright © 2008 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. The Cochrane Collaboration
Commentary on ‘Antibiotics to reduce post‐tonsillectomy morbidity’ with a response from the review author
Authors: Bromwich Matthew , Myer Charles M. , Dhiwakar M. 
Published: December 2008

AbstractThis is a commentary on a Cochrane review, published in this issue of EBCH, first published as: Dhiwakar M, Clement WA, Supriya M, McKerrow WS. Antibiotics to reduce post‐tonsillectomy morbidity. Cochrane Database of Systematic Reviews 2008, Issue 2. Art. No.: CD005607. DOI: 10.1002/14651858.CD005607.pub2.Further information for this Cochrane review is available in this issue of EBCH in the accompanying EBCH Summary and Characteristics and Key Findings Tables. Copyright © 2008 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. The Cochrane Collaboration
Characteristics and key findings for ‘Antibiotics to reduce post‐tonsillectomy morbidity’
Authors: van Dalen E. C. , Kremer L. C. M. 
Published: December 2008

AbstractThese are the characteristics and key findings for a Cochrane review published in this issue of EBCH, first published as: Dhiwakar M, Clement WA, Supriya M, McKerrow WS. Antibiotics to reduce post‐tonsillectomy morbidity. Cochrane Database of Systematic Reviews 2008, Issue 2. Art. No.: CD005607. DOI: 10.1002/14651858.CD005607.pub2.Further information for this Cochrane review is available in this issue of EBCH in the accompanying EBCH Commentary and Summary articles. Copyright © 2008 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. The Cochrane Collaboration
Characteristics and key findings for ‘Interventions for the interruption or reduction of the spread of respiratory viruses’
Authors: van Dalen E. C. , Kremer L. C. M. 
Published: December 2008

AbstractThese are the characteristics and key findings for a Cochrane review published in this issue of EBCH, first published as: Jefferson T, Foxlee R, Del Mar C, Dooley L, Ferroni E, Hewak B, Prabhala A, Nair S, Rivetti A. Interventions for the interruption or reduction of the spread of respiratory viruses. Cochrane Database of Systematic Reviews 2007, Issue 4. Art. No.: CD006207. DOI: 10.1002/14651858.CD006207.pub2.Further information for this Cochrane review is available in this issue of EBCH in the accompanying EBCH Commentary and Summary articles. Copyright © 2008 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. The Cochrane Collaboration
Characteristics and key findings for ‘Continuous heparin infusion to prevent thrombosis and catheter occlusion in neonates with peripherally placed percutaneous central venous catheters’
Authors: van Dalen E. C. , Offringa M. 
Published: December 2008

AbstractThese are the characteristics and key findings for a Cochrane review published in this issue of EBCH, first published as: Shah PS, Shah VS. Continuous heparin infusion to prevent thrombosis and catheter occlusion in neonates with peripherally placed percutaneous central venous catheters. Cochrane Database of Systematic Reviews 2008, Issue 2. Art. No.: CD002772. DOI: 10.1002/14651858.CD002772.pub3.Further information for this Cochrane review is available in this issue of EBCH in the accompanying EBCH Commentary and Summary articles. Copyright © 2008 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. The Cochrane Collaboration
Characteristics and key findings for ‘Cooling for newborns with hypoxic ischaemic encephalopathy’
Authors: van Dalen E. C. , Offringa M. 
Published: December 2008

AbstractThese are the characteristics and key findings for a Cochrane review published in this issue of EBCH, first published as: Jacobs SE, Hunt R, Tamow‐Mordi WO, Inder TE, Davis PG. Cooling for newborns with hypoxic ischaemic encephalopathy. Cochrane Database of Systematic Reviews 2007, Issue 4. Art. No.: CD003311. DOI 10.1002/14651858.CD003311.pub2.Further information for this Cochrane review is available in this issue of EBCH in the accompanying EBCH Commentary and Summary articles. Copyright © 2008 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. The Cochrane Collaboration
Tips and tricks for understanding and using SR results—no 12: Outcomes—don't be misled by results in which you are not interested
Authors: van der Lee Johanna H. 
Published: December 2008

AbstractThis twelfth article for ‘Tips and tricks for understanding and using SR results’ in Evidence Based Child Health is, like the previous ones, aimed at helping readers to understand the results of systematic reviews and to use the results in clinical practice. This time, we focus on outcomes. The information in this article is based on earlier papers, the Cochrane Handbook, and the experience of the author in teaching evidence‐based medicine. Copyright © 2008 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. The Cochrane Collaboration
Commentary on ‘Continuous heparin infusion to prevent thrombosis and catheter occlusion in neonates with peripherally placed percutaneous central venous catheters’
Authors: Bauman Mary E. , Massicotte M. Patricia 
Published: December 2008

AbstractThis is a commentary on a Cochrane review, published in this issue of EBCH, first published as: Shah PS, Shah VS. Continuous heparin infusion to prevent thrombosis and catheter occlusion in neonates with peripherally placed percutaneous central venous catheters. Cochrane Database of Systematic Reviews 2008, Issue 2. Art. No.: CD002772. DOI: 10.1002/14 651 858.CD002772.pub3.Further information for this Cochrane review is available in this issue of EBCH in the accompanying EBCH Summary and Characteristics and Key Findings Tables. Copyright © 2008 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. The Cochrane Collaboration