bluuebunny/crossref_metadata_2025_split huggingface dataset:
Repeat Peptide Receptor Radionuclide Therapy in Neuroendocrine Tumors: A NET Center of Excellence Experience
Authors: Grewal Udhayvir S , Loeffler Bradley T , Paschke Alexander , Dillon Joseph S. , Chandrasekharan Chandrikha 
Published: March 2024

Abstract
Introduction:
The available data for the safety and efficacy of repeat Peptide Receptor Radionuclide Therapy (PRRT) are almost exclusively from European centers. We present an updated experience with repeat PRRT in a cohort of US patients with neuroendocrine tumors (NETs) at our NET center of excellence.
Methods
We used our single-center longitudinal NET registry to identify patients who had been previously treated with at least one dose of PRRT (PRRT 1, either 177Lu DOTATATE or 90Y DOTATOC) and following radiographic disease progression (per RECIST 1.1 criteria) were re-treated with a second course of PRRT (PRRT 2). We reviewed patient, tumor and treatment characteristics, objective response rates and toxicities after PRRT 1 and PRRT 2.
Results
A total of 11 patients were included in the analysis. 45.5% (5/11) patients received 177 Lu DOTATATE PRRT only, both for PRRT1 and PRRT 2, while 54.5% (6/11) patients received 90Y DOTATOC PRRT for PRRT1. At first restaging scan after PRRT2 (3–6 months), 18.2% (2/11), 36.4% (4/11) and 27.3% (3/11) patients had PR, SD and PD respectively; 2/11 patients (18.2%) died before first restaging scan. Median PFS for PRRT1 (n = 11) was 25.4 months and median PFS (n = 10) for PRRT2 was 13.1 months (p = 0.0001). We did not find a statistically significant difference between the occurrence of short and long-term hematological toxicities as well as renal toxicity after PRRT1 and PRRT2.
Conclusion
We show that repeat PRRT may benefit select patients and has an acceptable safety profile. In our cohort, PFS was significantly lower after PRRT2 as compared to PRRT1.
Climate Change Projections of Potential Evapotranspiration for the North American Monsoon Region
Authors: Shamir Eylon , Mendoza-Fierro Lourdes , Karimi Sahar Mohsenzadeh , Pelak Norman , Chang Hsin-I , Castro Christopher 
Published: March 2024

Abstract

We assessed future projected changes in terrestrial evaporative demand by calculating Potential Evapotranspiration (PET) for the North American Monsoon region at the Southwest U.S. and Mexico. The PET projections were calculated using the daily Penman-Monteith equation and the terrestrial meteorological variables needed for the equation (i.e. minimum and maximum daily temperature, specific humidity, wind speed, incoming shortwave radiation, and pressure) were available from the North American – CORDEX initiative. We used six dynamically downscaled projections of three CMIP5 GCMs forced with RCP8.5 emission scenarios (i.e. HadGEM2-ES, MPI-ESM-LR, and GFDL-ESM2M), each was dynamically downscaled to ~ 25 km by two RCMs (i.e. WRF and regCM4). All terrestrial annual PET projections showed a statistically significant increase when comparing 1986–2005 to 2020–2039 and 2040–2059. The regional spatial average of the six climate models projected an increase in the annual PET of about + 4% and + 8% for 2020–2039 and 2040–2059, respectively. The projected average 20-year annual changes over the study area range respectively for the two projection periods were + 1.4%-+8.7% and + 3%-+14.2%. The projected annual PET increase trends are consistent across the entire region and for the 6 climate models. Higher annual changes are projected in the northeast part of the region, while smaller changes are projected along the pacific coast. The main drivers for the increase are the projected warming and increase in the vapor pressure deficit. The projected changes in PET, which represent the changes in the atmospheric evaporative demand, are substantial and likely to impact vegetation and the hydrometeorological regime in the area.
Evaluation of Sentinel-1 Satelite-based Soil Moisture Products for Runoff Modelling with Karst Formation Characteristics
Authors: Mawandha Hanggar Ganara , Pratama Afinafghani Duta , Ghifari M. Ramadhan Al , Hanifah Nasywa Hanin , Nursafa Issiami , Lestari Prieskarinda , Oishi Satoru 
Published: March 2024

Abstract

Soil moisture content is a crucial factor in hydrological studies as it helps to determine the rainfall and runoff response in the catchment. Land use, particularly cropping, can have a significant effect on soil moisture content. Hilly topography with karst features is more prone to flooding and soil erosion due to its low water holding capacity. Remote sensing technology has recently been applied to agriculture and disaster management. The aim of this research is to identify soil moisture characteristics in karst formations for runoff estimation using remotely sensed imagery from Sentinel-1. Soil moisture is calculated using the Topp model equation based on the soil dielectric value obtained from the Dubois model. By using different types of land use and soil moisture data from Sentinel-1, CN values can be generated and then used to estimate runoff. The results of the study show that extracting soil moisture information from Sentinel-1A with VV polarisation for karst areas is still challenging due to the high bias. The Sentinel-1 satellite soil moisture products could provide a real-time CN value that can be integrated with the rainfall runoff model. This research highlights the importance of monitoring soil moisture to determine CN values for flood mitigation.
Significant value of p53 accumulated in Invasive Ductal Breast Carcinoma
Authors: Baccouche Sami , Rebai Ahmed , Frikha Mounir , Daoud Jamel , Jlidi Rachid , Gargouri Ali 
Published: March 2024

Abstract
Background
The presence of a functional p53 protein is a key factor for the appropriate suppression of cancer development. The tumor suppressor p53 accumulates under stressful conditions, such as DNA damage, heat shock, hypoxia, and/or proto-oncogene activation, although conflicting reports exist on its transcriptional activity. A loss of p53 activity, by mutations or inhibition, is often associated with human malignancies. This work investigated the significant value of p53 accumulated in IDBC (Invasive Ductal Breast Carcinoma) and at the same time tries to arise different supports of this value.
Results:
To ensure this objective, we referred to two types of statistical analysis, the chi-square and logistic regression analysis. They confirmed the poor prognosis of p53 accumulated in IDBC (β* = -0.456 with p=0.00001) and showed that the independent variables (MDM2, BCL2, BAX and ER) formed an interesting model to explain the significant value of p53 accumulated in the IDBC. The predictive value of the model including the four biomarkers is AUC=93.5%, showing that if we take the expression status of the four biomarkers, we can deduce the status of p53 with a reliability of 93.5%.
The residual term, representing 6,5% and involved in this significant value, corresponds to intrinsic modifications of p53: alterations of the TP53 gene, p53-oncoprotein interaction or cytoplasmic sequestration. In fact, following the IHC results of three different antibodies that recognize wild type or mutant p53, we examined the status of polymorphism 72, which may inform LOH (loss of heterozygozity). We found LOH associated with TP53 mutations in the context of down-regulated p53 target genes revealed by IHC. Although wild type in some cases, p53 loses its transcriptional activity; this may be due to oxidation of cysteine residues in the core domain, either iSAPP interaction or its cytoplasmic sequestration.
Conclusion: P53 accumulated in IDBC had a significant value and the etiological factors of this value should be target for effective therapy.
Does the environmental impact of banks affect their financial performance?
Authors: Bressan Silvia 
Published: March 2024

Abstract
We study empirically the environmental impact of banks, i.e. the negative externality on the environment and the society deriving from the use of a natural resource or the emission of a pollutant. We find that environmental “impact ratios”, i.e. environmental damage costs in proportion to total revenues, are negatively correlated with bank profitability. Furthermore, banks with a stronger impact on the environment are valued less by equity market investors and pay less cash to share- holders. Among environmental categories, potential damages from greenhouse gas emissions or waste seem to be especially severe. We deliver important insights for banks´ environmental management. If bankers would be able to address businesses and practices to be more renewable and lower in their emissions, they could im- prove both the operating as well as the market performance. Thus, firms would be financially more stable, and could react smoothly to the recent introduction of stricter and onerous environmental regulations.
Image Colourization using Generative Adversarial Networks
Authors: Majumdar Soumya 
Published: March 2024

Abstract

Over the last decade, the process of automatic image colouration has been of significant interest for several application areas, including the restoration of aged or degraded images. Image colorization is a challenging task in computer vision that involves adding realistic colours to greyscale images. Traditional methods rely on handcrafted rules and heuristics, which can lead to inconsistent and inaccurate results. Generative adversarial networks (GANs) offer a promising solution for this problem by learning to generate realistic colour images from greyscale inputs. In this paper, we review the state-of-the-art techniques for image colorization using GANs. We discuss different architectures and loss functions used in GANs for colorization, as well as their advantages and limitations. We also provide an overview of the datasets used for training and evaluation and the metrics used for measuring the performance of the models. Finally, we discuss the potential applications of GAN-based colouration in various domains, such as art, photography, and medical imaging. Overall, we show that GAN-based approaches offer a powerful and flexible framework for image colorization, with the potential to revolutionize the way we perceive and manipulate visual content.
Investigation into gender disparity and students’ performance in geometry: a quasi-experimental study of final year Male and Female students’ geometry learning using Van Hiele’s Model
Authors: Enoch Suglo Kabinaa 
Published: March 2024

Abstract

There are mixed findings and views about gender gap in mathematics learning. Whiles some studies have revealed that only men have the capacity to dominate in mathematics as compared to their female counterparts, other studies have found that women have the potential to even outperform their male counterparts in mathematics. There continue to be growing uncertainty regarding male and female students learning and performance in mathematics. This current study however was designed to explore the nexus between gender and geometry performance in respect to male and female students’ geometry learning and performance. The study employed a one-group quasi-experimental design with a population and sample size of 360 and 186, respectively. Stratified and random sampling processes were used to select the sample members. Data for the study were collected using a questionnaire (Google form) and a Geometry Achievement Test (Pretest and posttest). Data analysis was done using SPSS’s descriptive procedures and a paired sample t-test. The study found that: 1) there was a significant difference between male and female students academic performance in geometry, p(<.000). 2) The study also found that the use of Van Hiele’s geometry thinking model contributed to an improved geometry learning and performance. The study therefore recommended that teachers should make use of the Van Hiele’s model in teaching geometry, give equal support or pay equal attention to both male and female students in the classroom during teaching and learning.
Time saved is time earned: Implementation of an agile workflow system in a high-volume radiation oncology centre Workflow optimization in radiation oncology
Authors: Chufal Kundan Singh , Ahmad Irfan , Miller Alexis Andrew , Umesh Preetha , Dwivedi Alok , Bhatia Kratika , Gairola Munish 
Published: March 2024

Abstract
Aims and Objectives:
To evaluate operational efficiency gains when utilizing an agile digital workflow system (DWS; OncFlow®) in the Radiation Oncology clinic over standard workflow (SW).
Materials and Methods
Two Radiation Oncology teams in the same institution, one using DWS and the other SW, were prospectively assessed to compare the following operational parameters: consultation waiting time, communication errors, and data retrieval. We employed non-parametric tests and an unpaired t-test for statistical analysis.
Results
Digital workflow patients experienced a median consultation waiting time of 5.5 minutes (95% CI: 4.7–6.3) compared to 17.9 minutes (95% CI: 14.2–21.6) in the standard workflow, with the difference being significant (p < 0.0001). Communication-related incidents each month were significantly lower in the DWS group, with a median of 1 incident (range: 0–3) compared to 4 incidents (range: 1–5) in the SW (p < 0.001). Planned data retrieval was also considerably faster with DWS.
Conclusion
Digital workflow systems significantly reduce consultation waiting times and communication errors, enhancing efficiency in the Radiation Oncology clinic. Faster data retrieval also reduced research turnaround time. Broader application in more diverse working environments is warranted.
Equisetum diffusum methanolic extract attenuates arthritis through the modulation of key inflammatory biomarkers like COX-2, TNF-α, IL-6, PPAR-γ and Iκβ expression in Adjuvant-induced rats.
Authors: Sarkar Sourav , Modak Debabrata , Roy Sudipta Kumar , Ashraf Gouhar Jahan , Chakrabarty Ayan , Sahu Ranabir , Bhattacharjee Soumen 
Published: March 2024

Abstract

Rheumatoid arthritis (RA) is a chronic inflammatory disease associated with subsequent damage to the bone joints. Equisetum diffusum D. Don, from the Equisetaceaefamily, is a native pteridophyte species of the sub-Himalayan region of India and has been reported to have a diverse array of pharmacological properties. The present research is focused on determining the anti-arthritic potential of E. diffusum whole plant methanolic extract (EDME) in adjuvant-induced arthritic rats. Treatment with EDME significantly restored paw-edema, arthritic scoring, and normal body weight. EDME treatment also normalized the haematological, biochemical, radiological, and histological status when compared to the arthritic control rats. The methanolic extract significantly (p<0.05) attenuated arthritis progression by downregulating the gene expression of pro-inflammatory mediators, like COX-2, TNF-α, IL-6, and upregulating the expression of anti-inflammatory mediators PPAR-γ, Iκβ in a dose-dependent manner. Significantly, EDME also reduced the serum concentration of COX-2, TNF-α, and IL-6 compared to arthritic control rats (p<0.05). The treatment with EDME also normalized the oxidative stress level in liver by restoring the GSH level, CAT and SOD activities and reducing the elevated MDA level. HPTLC and LC-MS/MS analyses of EDME confirmed the presence of potent polyphenols (chlorogenic acid, 4-hydroxycinnamic acid) and flavonoids (kaempferol), thereby suggesting the anti-arthritic property of the plant. All our findings established the anti-arthritic potential of E. diffusum extract in chronic arthritis model on a strong ground.
Seismic analysis of a multi storied steel building provided with different types of damper and base isolation
Authors: Patil Aishwarya Yogesh 
Published: March 2024

Abstract
This manuscript research presents the design of steel building and analysis of different damper and base isolation systems at various seismic zone for a multi-storied steel framed building (MSSB). Steel buildings are easy to build and gives more strength, also after demolish there are scrap value so ties more economical. Base isolation provides structural safety and also safety and security for people and properties in the building. Base isolation is also used for the retrofit of the historic buildings. In the present manuscript work done on, Seismic analysis of G+10 multi storied steel building with and without dampers (viscous damper and friction damper) and base isolation system (friction isolation and lead plug bearing). In this types of seismic provision which one is more suitable according to seismic zone for stabilization of steel building analyzed. In this work used seismic zone II, zone III, zone IV and zone V by using ETABs software analysis carried out. Found the optimum damper and base isolation combination effect in the steel building and analysis result of responses (viz. storey drift, storey displacement, base shear).
Rare Manifestations of Gastric Cancer: Leptomeningeal Carcinomatosis Without Other Metastases
Authors: Alwaw Ricarda , Ammouri Yara , Allabwani Abdalqader , Yazbek Majd , Alhussin Mohammad , Alrefaei Bayan 
Published: March 2024

Abstract
Neurovascular conditions in cancer patients can result from the tumor itself, cancer treatment side effects, hypercoagulability, or a weakened immune system. CVT is common in patients with hematological malignancies, especially leukemia. Leptomeningeal disease (LMD) is a rare but devastating complication in advanced cancer. A 53-year-old man presented with a 20-day history of headaches, right-sided weakness, and seizures. Examination revealed normal cranial nerves, weak upper (3/5) and lower (2/5) right limbs. CSF analysis showing 16 lymphocytes/µL, protein of 20 mg/dL, and glucose of 42 mg/dL. Cytologic examination was positive for adenocarcinoma cells. Upper GI endoscopy revealed a gastric ulcer with malignant features. Leptomeningeal carcinomatosis (LM) is the harmful invasion of the pia mater and arachnoid membrane, occurring in 5–15% of cancer patients. The average survival time is 2 to 6 months, with poor prognosis associated with age over 50, poor performance status, short interval between cancer diagnosis and LM, primary lung cancer or melanoma, and lack of treatment response. Gastric cancer, the fourth most common tumor and second cause of death worldwide, rarely metastasizes to the meninges (0.1–0.69%). This case describes a patient with gastric adenocarcinoma who developed LM, an unusual manifestation, without other metastases.
A Referential Interpretation al-Jaryī wa al-Inṭibāq: Approach (Tafsīr Taṭbīqī) for Digging The Inner Meaning of al-Qur'an.
Authors: Kerwanto Kerwanto 
Published: March 2024

Some important criteria that must be considered by the commentator in determining the inner (esoteric) meaning of the Qur'an are that it must not conflict with the literal text, mutawatir hadiths and important religious principles (dharuriyāt ad-dīn). Once the requirements that must be met in the interpretation are so strict, not a few products of isyari interpretation (Sufi interpretation) are considered deviant and trapped in tafsir bi al-ra’yī al-madzmum (despicable interpretation). Therefore, it is important to carry out several in-depth reviews of various approaches and rules of interpretation that can be used as a medium for revealing and explaining the inner meaning of the Qur'an.
In this article, the author tries to clarify the important position of the rule of al-jaryī wa al-Inṭibāq in the interpretation of the Qur'an, which is very likely in some cases not paid attention to by some commentators. For the author, this rule can be a bridge in determining the validity of the inner meaning of the Qur'an because the main element of this rule is the hadiths that are related to the context of the nuzūl verse. The main working principle of this rule is to try to apply certain references intended by the verses of the Qur'an to several different individuals at different times and places with the context of the initial nuzul of the verse. This rule seeks to find new meanings from the general concept of the verse which is abstracted from hadith data that is related to the context of its nuzul.
Overview of Synthesis and Applications of Unnatural Lipophilic α-Amino Acids
Authors: Bhamboo Prateek , Bera Smritilekha , Mondal Dhananjoy 
Published: March 2024

Abstract:
Naturally and synthetically obtained lipophilic α-amino acids exhibit diverse
properties and applications in academia and industry. Unnatural hydrophobic/lipophilic
amino acids lacking polarity in their side chains manifest the biologically significant structure
of peptides and proteins. The hydrophobic effect of lipophilic amino acids stabilizes the
structure of proteins, peptides, and enzymes during their indigenous folding-unfolding phenomena.
The presence of these amino acids in the backbone of protein and peptide-derived
drug delivery systems such as lysine-derived surfactants and glycodendrimers can also enhance
the cell penetration of drugs of interest. Cationic poly-l-lysine dendrimers, α-amino
oleic acid, and a naturally occurring cyclic heptadepsipeptide HUN-7293 are recognized as
promising biomaterials for developing prodrugs and also serve as biocompatible surfactants
in the food, cosmetic and pharmaceutical industries. The synthesis of unnatural lipophilic amino acids, N-lauroyl
sarcosine, N-lauroyl glutamic acid, N-octylglycine, N-myristoyl glycine etc. has gained attention for preparing
novel compounds for advanced academic, industrial, and societal applications. This review article discusses the
applications and synthesis of hydrophobic/lipophilic α-amino acids using ester enolate Claisen rearrangement,
chiral auxiliary, chiral pool, chiral catalysts, and many more relevant methodologies.
Bionanofactories for the Environmental Friendly Fabrication of Silver
Nanoparticles: Application to the Analysis of Antimicrobial Agents
Authors: Prajapati Shatrudhan , Yadav Shikha , Khan Javed 
Published: March 2024

Abstract:
The green synthesis of silver nanoparticles has garnered significant interest because of
the unique physicochemical and biological properties they possess. These nanoparticles could have
applications in a wide variety of fields, including biomedicine, cellular imaging, cosmetics,
healthcare tourism, food and agriculture. The formation of nanoparticles is facilitated by the use of
bionanofactories, or green synthesis processes, which utilise living organisms, biomolecules, and
plant-based materials as bio reductive or bio sealing agents. Green chemistry is cost-effective in addition
to being environmentally friendly, non-toxic, and biodegradable. By considering the results
of recent studies using techniques like scanning electron microscopy, transmission electron microscopy,
atomic force microscopy, ultraviolet/visible spectrophotometry, Fourier transform infrared
spectroscopy or X-ray diffraction, we illuminate the most recent advances in green synthesis and
the physicochemical properties of green silver nanoparticles. We also discuss the properties of silver
nanoparticles that make them effective against bacteria, fungi, and parasites.