bluuebunny/crossref_metadata_2025_split huggingface dataset:
EFFECT OF STRATIFIED DOSE OF NOREPINEPHRINE ON CELLULAR IMMUNE RESPONSE IN PATIENTS WITH SEPTIC SHOCK AND THE CONSTRUCTION OF A PROGNOSTIC RISK MODEL
Authors: Wang Qiang , Tang Jiefu , Li Yao , Lu Jiafei , Yang Dexing , He Chen , Li Ting , Fu Kai , Liu Rong 
Published: March 2024

ABSTRACT

Objective: To explore the effect of a stratified dose of norepinephrine (NE) on cellular immune response in patients with septic shock, and to construct a prognostic model of septic shock. Methods: A total of 160 patients with septic shock (B group) and 58 patients with sepsis (A group) were given standard cluster therapy. Patients with septic shock were divided into four groups (B1-B4 groups: 0.01–0.2, 0.2–0.5, 0.5–1.0, and >1 μg/kg/min) according to the quartile method of the early (72 h) time-weighted average dose of NE and clinical application. The cellular immune indexes at 24 h (T0) and 4–7 days (T1) after admission were collected. The difference method was used to explore the effect of NE stratified dose on cellular immune effect in patients with septic shock. A multivariate COX proportional risk regression model was used to analyze the independent prognostic risk factors, and a prognostic risk model was constructed. Results: The differences of ΔIL-1β, ΔIL-6, ΔIL-10, absolute value difference of T lymphocyte (ΔCD3+/CD45+#) and Th helper T cell (ΔCD3+ CD4+/CD45+#), CD64 infection index difference, ΔmHLA-DR, regulatory T lymphocyte ratio difference (ΔTregs%) between group A, B1, B2, B3, and B4 were statistically significant (P < 0.05). There was a nonlinear relation between the stratified dose of NE and ΔIL-6, ΔIL-10, ΔCD3+/CD45+#, ΔmHLA-DR%. The threshold periods of NE-induced proinflammatory and anti-inflammatory immune changes were 0.3–0.5 μg/kg/min. Multivariate COX model regression analysis showed that age, nutritional patterns, weighted average dose of norepinephrine, IL-6, absolute value of T lymphocytes, and mHLA-DR were independent risk factors affecting the prognosis of patients with septic shock (P < 0.05). The prognostic risk model was constructed (AUC value = 0.813, 95% CI: 0.752–0.901). Conclusion: NE has a certain inhibitory effect on cellular immune function in patients with septic shock. A prognostic risk model was constructed with stronger prediction efficiency for the prognosis of patients with septic shock.
Peer Teachers' Professional Identity Development During a Prehospital Simulation
Authors: Cole Rebekah , Hildreth Amy , Pickering Robert G. , Rudinsky Sherri L. 
Published: March 2024

Introduction
Peer teachers have been found to be effective instructors during simulation-based education. However, there is a lack of research regarding their professional identity development throughout the course of the teaching activity. The purpose of this qualitative study, therefore, was to develop a framework to illustrate how peer teachers develop as educators during a prehospital simulation.

Methods
The participants in our study were 9 second-year medical students serving as peer teachers during a multiday prehospital simulation. We selected the grounded theory tradition of qualitative research to investigate the peer teachers' professional identity development. Our research team interviewed each participant twice during the simulation. We then used open and axial coding to analyze the interview data. We organized these codes into categories and determined connections between each category to construct our grounded theory framework.

Results
This framework described how the peer teachers progressed through 4 stages: 1) eager excitement, 2) grounded by challenges, 3) overcoming challenges, and 4) professional identity formation.

Conclusion
Our results revealed that simulation-based education can serve as valuable learning environment not only for medical students, but also for peer teachers. Understanding their progressive development during the simulation will help medical educators focus on maximizing the peer teachers' growth and development during simulation.
A constricted mitochondrial morphology optimizes respiration
Authors: Singh Manish K. , Cavellini Laetitia , Kunz Christina , Lelek Mickaël , Bomme Perrine , Belgareh-Touzé Naïma , Mallet Adeline , Dietrich Lea , Zimmer Christophe , Cohen Mickael M. 
Published: March 2024

AbstractMitochondria assemble in a dynamic tubular network with a morphology governed by mitochondrial fusion and fission, which regulate all mitochondrial functions including oxidative phosphorylation1–4. Yet, the link between mitochondrial morphology and respiration remains unclear5–9. Here, we discover a previously unknown mitochondrial morphology dedicated to respiratory growth ofSaccharomyces cerevisiae, which we refer to as “Ringo”. The Ringo morphology is characterized by stable constrictions of mitochondrial tubules. Ringo constrictions are mediated by the yeast dynamin Dnm1 and, unlike mitochondrial fission10–12, occur in the absence of contacts with the endoplasmic reticulum. Our data show that the Ringo morphology regulates mitochondrial DNA homeostasis during respiration to ensure stoichiometric assembly of OXPHOS complexes, demonstrating that the shape of mitochondria actively contributes to optimal respiration.One-Sentence Summary:We report a new mitochondrial morphology that actively contributes to optimal respiration in yeast.
Neurogranin modulates the Rate of Association between Calmodulin and Target Peptides
Authors: Putkey John A. , Hoffman Laurel , Berka Vladimir , Wang Xu 
Published: March 2024

ABSTRACTThe best-known mode of action of calmodulin (CaM) is binding of Ca2+to its N- and C-domains, followed by binding to target proteins. An underappreciated facet of this process is that CaM is typically bound to proteins at basal levels of free Ca2+, including the small, intrinsically disordered, neuronal IQ-motif proteins called PEP-19 and neurogranin (Ng). PEP-19 and Ng would not be effective competitive inhibitors of high-affinity Ca2+-dependent CaM targets at equilibrium since they bind to CaM with relatively low affinity, but they could influence the time course of CaM signaling by affecting the rate of association of CaM with high-affinity Ca2+-dependent targets. This mode of regulation may domain specific since PEP-19 binds to the C-domain of CaM, while Ng binds to both N- and C-domains. In this report, we used a model CaM binding peptide (CKIIp) to characterize the preferred pathway of complex formation with Ca2+-CaM at low levels of free Ca2+(0.25 to 1.5 µM), and how PEP-19 and Ng affect this process. We show that the dominant encounter complex involves association of CKIIp with the N-domain of CaM, even though the C-domain has a greater affinity for Ca2+. We also show that Ng greatly decreases the rate of association of Ca2+-CaM with CKIIp due to the relatively slow dissociation of Ng from CaM, and to interactions between the Gly-rich C-terminal region of Ng with the N-domain of CaM, which inhibits formation of the preferred encounter complex with CKIIp. These results provide the general mechanistic paradigms that binding CaM to targets can be driven by its N-domain, and that low-affinity regulators of CaM signaling have the potential to influence the rate of activation of high-affinity CaM targets and potentially affect the distribution of limited CaM among multiple targets during Ca2+oscillations.STATEMENT OF SIGNIFICANCECalmodulin is a small, essential regulator of multiple cellular processes including growth and differentiation. Its best-known mode of action is to first bind calcium and then bind and regulate the activity of target proteins. Each domain of CaM has distinct calcium binding properties and can interact with targets in distinct ways. We show here that the N-domain of calmodulin can drive its association with targets, and that a small, intrinsically disordered regulator of calmodulin signaling called neurogranin can greatly decrease the rate of association of CaM with high-affinity Ca2+-dependent targets. These results demonstrate the potential of neurogranin, and potentially other proteins, to modulate the time course of activation of targets by a limited intracellular supply of calmodulin.
PLD3 and PLD4 synthesizeS,S-BMP, a key phospholipid enabling lipid degradation in lysosomes
Authors: Singh Shubham , Dransfeld Ulrich , Ambaw Yohannes , Lopez-Scarim Joshua , Farese Robert V. , Walther Tobias C. 
Published: March 2024

SUMMARYBis(monoacylglycero)phosphate (BMP) is an abundant lysosomal phospholipid required for degradation of lipids, in particular gangliosides. Alterations in BMP levels are associated with neurodegenerative diseases. Unlike typical glycerophospholipids, lysosomal BMP has two chiral glycerol carbons in theS(rather than theR) stereo-conformation, protecting it from lysosomal degradation. How this unusual and yet crucialS,S-stereochemistry is achieved is unknown. Here we report that phospholipases D3 and D4 (PLD3 and PLD4) synthesize lysosomalS,S-BMP, with either enzyme catalyzing the critical glycerol stereo-inversion reactionin vitro. Deletion of PLD3 or PLD4 markedly reduced BMP levels in cells or in murine tissues where either enzyme is highly expressed (brain for PLD3; spleen for PLD4), leading to gangliosidosis and lysosomal abnormalities. PLD3 mutants associated with neurodegenerative diseases, including Alzheimer’s disease risk, diminished PLD3 catalytic activity. We conclude that PLD3/4 enzymes synthesize lysosomalS,S-BMP, a crucial lipid for maintaining brain health.
Toddy trends and the organic conundrum: a closer look at consumer behaviour with decision tree
Authors: Sukumaran Likhil , Majhi Ritanjali 
Published: March 2024

PurposeThis study aims to explore and understand the challenges and opportunities presented by the rising demand for organic products in the context of toddy consumption and marketing.Design/methodology/approachThis research examines consumer behaviour and decision-making patterns using decision tree analysis. A survey questionnaire based on established theories was distributed to individuals above the legal drinking age of 23 in Kerala, India, using purposive and random sampling.FindingsThe study found that people's fondness for toddy shop food plays a crucial role in their food choices. When the fondness is low, subjective norms can override personal preferences. But when the fondness is high, individual perceptions take precedence.Originality/valueUsing machine learning techniques, we created a compass to guide marketing strategies and cultural preservation efforts in toddy shops by considering the complex factors that influence consumer decisions.
What is beautiful is good: attractive avatars for healthier dining and satisfaction
Authors: Hao Fei , Aman Adil Masud , Zhang Chen 
Published: March 2024

Purpose
As technology increasingly integrates into the restaurant industry, avatar servers present a promising avenue for promoting healthier dining habits. Grounded in the halo effect theory and social comparison theory, this study aims to delve into the influence of avatars' appearance, humor and persuasion on healthier choices and customer satisfaction.

Design/methodology/approach
This paper comprises three experimental studies. Study 1 manipulates avatar appearance (supermodel-looking vs normal-looking) to examine its effects on perceived attractiveness, warmth and relatability. These factors influence customer satisfaction and healthy food choices through the psychological mechanisms of social comparison and aspirational appeal. Studies 2 and 3 further refine this theoretical model by assessing the interplay of appearance with humor (presence vs absence) and persuasion (health-oriented vs beauty-oriented), respectively.

Findings
Results suggest that avatars resembling supermodels evoke stronger aspirational appeal and positive social comparison due to their attractiveness, thus bolstering healthier choices and customer satisfaction. Moreover, humor moderates the relationship between appearance and attractiveness, while persuasion moderates the effects of appearance on social comparison and aspirational appeal.

Research limitations/implications
This research bridges the halo effect theory and social comparison theory, offering insights enriching the academic discourse on technology’s role in hospitality.

Practical implications
The findings provide actionable insights for managers, tech developers and health advocates.

Originality/value
Despite its significance, avatar design research in the hospitality sector has been overlooked. This study addresses this gap, offering a guideline for crafting attractive and persuasive avatars.
The rise of sustainable approaches in development of waterproof breathable fabrics for garment: a systematic literature review
Authors: Kumar Abhishek , Manshahia Manpreet 
Published: March 2024

PurposeThe aim of this study is to present an overview of sustainable practices in the development of waterproof breathable fabrics for garments. It aims to provide insights into the current state of academic research in this domain and identify and analyze major sustainable trends in the field.Design/methodology/approachThis study conducts a thorough examination of research publications sourced from the Scopus database spanning the years 2013–2023 by employing a systematic approach. The research utilizes both descriptive analysis and content analysis to identify trends, notable journals and leading countries in sustainable waterproof breathable fabric development.FindingsThe study reveals a notable increase in studies focusing on sustainable approaches in the development of waterproof breathable fabrics for garments. Descriptive analysis highlights the most prominent journal and leading country in terms of research volume. Content analysis identifies four key trends: minimizing chemical usage, developing easily degradable materials, creating fabrics promoting health and well-being and initiatives to reduce energy consumption.Research limitations/implicationsThe main limitation of this research lies in its exclusive reliance on the Scopus database.Practical implicationsThe insights derived from this study offer practical guidance for prospective researchers interested in investigating sustainable approaches to developing waterproof breathable fabric for garments. The identified trends provide a foundation for aligning research endeavors with contemporary global perspectives, facilitating the integration of sustainable methodologies into the garment industry.Originality/valueThis systematic literature review contributes original insights by synthesizing current research trends and outlining evolving sustainable practices in the development of waterproof breathable fabrics. The identification of key focus areas adds a novel perspective to existing knowledge.
Development and application of temperature-sensing underwear for breast monitoring
Authors: Huang Yu , Ji Xiaofen , Zhai Lina , Ocran Francisca Margarita 
Published: March 2024

Purpose Breast cancer has become the largest cancer in the world today. Health problems for women with breast cancer need to be addressed urgently. This study aims to select the best method for preparing temperature-sensitive sports underwear, and to verify the feasibility of using K-type thermocouple threads in underwear fabrics.Design/methodology/approach In the experiments, two samples were designed for temperature-sensitive performance tests and the effects produced by different outer layer structures were investigated. In the second step, K-type thermocouple wires were integrated into sports underwear. The comfort and feasibility of the temperature-sensitive underwear were investigated.Findings It was finally verified to obtain the best comfort and temperature-sensing performance of K-type thermocouple filaments integrated into sports underwear with plain stitching.Originality/value The underwear has a certain prospect for the application of smart apparel based on breast cancer health monitoring, which is of some significance for monitoring smart apparel.
Impact of information system flexibility and dynamic capabilities in building net zero supply chains
Authors: Singh Rohit Kumar , Modgil Sachin 
Published: March 2024

PurposeThe main aim of this study is to explore the relationship between information system flexibility and dynamic capabilities to build sustainable and net zero supply chains under the influence of environmental dynamism.Design/methodology/approachWe have formulated a self-administered survey, with 359 participants contributing responses. Prior to delving into foundational assumptions, such as homoscedasticity and normality, a nonresponse bias analysis was executed. The integrity of the data, in terms of reliability and construct validity, was gauged using confirmatory factor analysis. Subsequent regression outputs corroborated all the proposed assumptions, fortifying the extant scholarly literature.FindingsThe empirical findings of this research underscore a positive correlation between Information system flexibility, dynamic capabilities and a net zero supply chain, especially in the context of environmental dynamism. Data sourced from the cement manufacturing sector support these observations. We also found that environmental dynamism moderates the relationship between data analytics capability and sustainable supply chain flexibility but does not moderate the relationship between Resource flexibility and sustainable supply chain flexibility. Additionally, this research strengthens the foundational principles of the dynamic capability theory.Originality/valueThe conceptual framework elucidates the interplay between information system flexibility, dynamic capabilities, and sustainable supply chain flexibility, emphasizing their collective contribution towards achieving sustainable chain net zero, introducing environmental dynamics as a moderating variable that augments the scholarly discourse with a nuanced layer of analytical depth.
Linking customer mindsets, brand engagement, and citizenship behavior: the moderating role of brand trust
Authors: Soomro Suhaib Ahmed , Eyupoglu Serife Zihni , Ali Fayaz 
Published: March 2024

Purpose
The paper aims to explore the relationship between customer mindsets and customer citizenship behavior. This study used the cognitive-affective-behavioral model to examine how customer mindsets relate to customer citizenship behavior. In addition, it investigated the mediating effect of customer brand engagement and moderating role of brand trust.

Design/methodology/approach
The study used a self-administered online survey from 412 respondents using cellular mobile operating brands. Partial least square structural equation modeling was used to analyze the collected data.

Findings
The results revealed that growth-mindset customers directly and significantly influence customer citizenship behavior. The impact of a fixed mindset on customer citizenship behavior is indirect through customer brand engagement. The moderating findings revealed that the effect of brand trust on the relationship between customer brand engagement and customer citizenship behavior is higher than that between the fixed mindset and customer brand engagement.

Practical implications
The findings provide valuable insights for marketing and brand managers to design marketing campaigns considering different mindsets to generate customer citizenship behavior among customers.

Originality/value
This study provides new avenues in consumer psychology and behavior by unfolding the underlying mechanism through which mindsets lead to customer citizenship behavior, contributing to existing knowledge by extending the cognitive-affective-behavioral model.
A heuristic-based benders decomposition for the hybrid relief distribution network minimizing deprivation cost of vulnerable areas
Authors: Khalaj Rahimi Sanaz , Rahmani Donya 
Published: March 2024

PurposeThe study aims to optimize truck routes by minimizing social and economic costs. It introduces a strategy involving diverse drones and their potential for reusing at DNs based on flight range. In HTDRP-DC, trucks can select and transport various drones to LDs to reduce deprivation time. This study estimates the nonlinear deprivation cost function using a linear two-piece-wise function, leading to MILP formulations. A heuristic-based Benders Decomposition approach is implemented to address medium and large instances. Valid inequalities and a heuristic method enhance convergence boundaries, ensuring an efficient solution methodology.Design/methodology/approachResearch has yet to address critical factors in disaster logistics: minimizing the social and economic costs simultaneously and using drones in relief distribution; deprivation as a social cost measures the human suffering from a shortage of relief supplies. The proposed hybrid truck-drone routing problem minimizing deprivation cost (HTDRP-DC) involves distributing relief supplies to dispersed demand nodes with undamaged (LDs) or damaged (DNs) access roads, utilizing multiple trucks and diverse drones. A Benders Decomposition approach is enhanced by accelerating techniques.FindingsIncorporating deprivation and economic costs results in selecting optimal routes, effectively reducing the time required to assist affected areas. Additionally, employing various drone types and their reuse in damaged nodes reduces deprivation time and associated deprivation costs. The study employs valid inequalities and the heuristic method to solve the master problem, substantially reducing computational time and iterations compared to GAMS and classical Benders Decomposition Algorithm. The proposed heuristic-based Benders Decomposition approach is applied to a disaster in Tehran, demonstrating efficient solutions for the HTDRP-DC regarding computational time and convergence rate.Originality/valueCurrent research introduces an HTDRP-DC problem that addresses minimizing deprivation costs considering the vehicle’s arrival time as the deprivation time, offering a unique solution to optimize route selection in relief distribution. Furthermore, integrating heuristic methods and valid inequalities into the Benders Decomposition approach enhances its effectiveness in solving complex routing challenges in disaster scenarios.