bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of diminished ovarian reserve on the outcome of fresh embryo transfer in IVF/ICSI cycles among young women: A retrospective cohort study
Authors: Zhu Suqin , Jiang Wenwen , Liao Xiuhua , Sun Yan , Chen Xiaojing , Zheng Beihong 
Published: April 2024

Abstract
Objective
This study aims to investigate the effect of diminished ovarian reserve (DOR) on the clinical outcomes and maternal and infant safety of in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) procedures in young women aged ≤ 35 years.

Methods
A retrospective cohort study was performed to analyze the clinical data of 4,203 infertile women aged ≤ 35 years who underwent fresh embryo transfer (ET) in IVF/ICSI cycles. The data were collected from their initial visits to Fujian Maternity and Child Health Hospital between January 2015 and January 2022. Based on their ovarian reserve, the participants were categorized into two groups: DOR group (n = 1,027) and non-DOR group (n = 3,176). A propensity score matching (PSM) method was employed to ensure a relatively balanced distribution of covariates. The primary outcome assessed in this study was the live birth rate, while the secondary observation indicators included rates of high-quality embryo development, blastocyst formation, clinical pregnancy, and miscarriage, along with perinatal complications, neonatal birth weight, and the incidence of low birth weight (LBW).

Results
The DOR group showed notably lowered rates of blastocyst formation (59.8% vs. 64.1%), embryo implantation (29.8% vs.33.3%), clinical pregnancy (47.9% vs. 53.6%), and live birth (40.6% vs. 45.7%) compared to the non-DOR group (all P < 0.05). However, no statistically significant differences were observed in the high-quality embryo rate, miscarriage rate, perinatal complications, neonatal birth weight, or LBW incidence in infants between both groups (all P > 0.05).

Conclusion
DOR has been found to reduce both clinical pregnancy and live birth rates in young females undergoing fresh ET in IVF/ICSI cycles. However, this reduction does not increase the risk of perinatal complications or LBW of infants through live birth cycles.
A qualitative study of leaders’ experiences of handling challenges and changes induced by the COVID-19 pandemic in rural nursing homes and homecare services
Authors: Glette Malin Knutsen , Kringeland Tone , Samal Lipika , Bates David W. , Wiig Siri 
Published: April 2024

Abstract
Background
The COVID-19 pandemic had a major impact on healthcare services globally. In care settings such as small rural nursing homes and homes care services leaders were forced to confront, and adapt to, both new and ongoing challenges to protect their employees and patients and maintain their organization's operation. The aim of this study was to assess how healthcare leaders, working in rural primary healthcare services, led nursing homes and homecare services during the COVID-19 pandemic. Moreover, the study sought to explore how adaptations to changes and challenges induced by the pandemic were handled by leaders in rural nursing homes and homecare services.

Methods
The study employed a qualitative explorative design with individual interviews. Nine leaders at different levels, working in small, rural nursing homes and homecare services in western Norway were included.

Results
Three main themes emerged from the thematic analysis: “Navigating the role of a leader during the pandemic,” “The aftermath – management of COVID-19 in rural primary healthcare services”, and “The benefits and drawbacks of being small and rural during the pandemic.”

Conclusions
Leaders in rural nursing homes and homecare services handled a multitude of immediate challenges and used a variety of adaptive strategies during the COVID-19 pandemic. While handling their own uncertainty and rapidly changing roles, they also coped with organizational challenges and adopted strategies to maintain good working conditions for their employees, as well as maintain sound healthcare management. The study results establish the intricate nature of resilient leadership, encompassing individual resilience, personality, governance, resource availability, and the capability to adjust to organizational and employee requirements, and how the rural context may affect these aspects.
Long noncoding RNA UNC5B-AS1 suppresses cell proliferation by sponging miR-24-3p in glioblastoma multiforme
Authors: Song Ying , Chen Baodong , Jiao Huili , Yi Li 
Published: April 2024

Abstract
Background
Glioblastoma multiforme (GBM) is the most common primary CNS tumor, characterized by high mortality and heterogeneity. However, the related lncRNA signatures and their target microRNA (miRNA) for GBM are still mostly unknown. Therefore, it is critical that we discover lncRNA markers in GBM and their biological activities.

Materials and methods
GBM-related RNA-seq data were obtained from the Cancer Genome Atlas (TCGA) database. The “edger” R package was used for differently expressed lncRNAs (DELs) identification. Then, we forecasted prospective miRNAs that might bind to lncRNAs by Cytoscape software. Survival analysis of those miRNAs was examined by the starBase database, and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis of the miRNAs’ target genes was conducted by the Gene Set Enrichment Analysis (GSEA) database and R software. Moreover, the proliferative ability of unc-5 netrin receptor B antisense RNA 1 (UNC5B-AS1) cells was evaluated by Cell Counting Kit-8 (CCK-8) analysis. Mechanistically, the regulatory interaction between UNC5B-AS1 and miRNA in GBM biological processes was studied using CCK-8 analysis.

Results
Our results indicated that overexpression of UNC5B-AS1 has been shown to suppress GBM cell growth. Mechanistically, miR-24-3p in GBM was able to alleviate the anti-oncogenic effects of UNC5B-AS1 on cell proliferation.

Conclusion
The discovery of the novel UNC5B-AS1-miR-24-3p network suggests possible lncRNA and miRNA roles in the development of GBM, which may have significant ramifications for the analysis of clinical prognosis and the development of GBM medications.
Enhancing therapeutic efficacy in luminal androgen receptor triple-negative breast cancer: exploring chidamide and enzalutamide as a promising combination strategy
Authors: Zhao Ya-Xin , Wang Han , Zhang Si-Wei , Zhang Wei-Xin , Jiang Yi-Zhou , Shao Zhi-Ming 
Published: April 2024

AbstractExtensive exploration of the molecular subtypes of triple-negative breast cancer (TNBC) is critical for advancing precision medicine. Notably, the luminal androgen receptor (LAR) subtype has attracted attention for targeted treatment combining androgen receptor antagonists and CDK4/6 inhibitors. Unfortunately, this strategy has proven to be of limited efficacy, highlighting the need for further optimization. Using our center’s comprehensive multiomics dataset (n = 465), we identified novel therapeutic targets and evaluated their efficacy through multiple models, including in vitro LAR cell lines, in vivo cell-derived allograft models and ex vivo patient-derived organoids. Moreover, we conducted flow cytometry and RNA-seq analysis to unveil potential mechanisms underlying the regulation of tumor progression by these therapeutic strategies. LAR breast cancer cells exhibited sensitivity to chidamide and enzalutamide individually, with a drug combination assay revealing their synergistic effect. Crucially, this synergistic effect was verified through in vivo allograft models and patient-derived organoids. Furthermore, transcriptomic analysis demonstrated that the combination therapeutic strategy could inhibit tumor progression by regulating metabolism and autophagy. This study confirmed that the combination of histone deacetylase (HDAC) inhibitors and androgen receptor (AR) antagonists possessed greater therapeutic efficacy than monotherapy in LAR TNBC. This finding significantly bolsters the theoretical basis for the clinical translation of this combination therapy and provides an innovative strategy for the targeted treatment of LAR TNBC.
Efficacy and safety of artemether-lumefantrine for the treatment of uncomplicated falciparum malaria in mainland Tanzania, 2019
Authors: Ngasala Billy E. , Chiduo Mercy G. , Mmbando Bruno P. , Francis Filbert T. , Bushukatale Samwel , Makene Twilumba , Mandara Celine I. , Ishengoma Deus S. , Kamugisha Erasmus , Ahmed Maimuna , Mahende Muhidin K. , Kavishe Reginald A. , Muro Florida , Molteni Fabrizio , Reaves Erik , Kitojo Chonge , Greer George , Nyinondi Ssanyu , Kabula Bilal , Lalji Shabbir , Chacky Frank , Njau Ritha J. , Warsame Marian , Mohamed Ally 
Published: April 2024

Abstract
Background
Artemisinin-based combination therapy (ACT) has been a major contributor to the substantial reductions in global malaria morbidity and mortality over the last decade. In Tanzania, artemether-lumefantrine (AL) was introduced as the first-line treatment for uncomplicated Plasmodium falciparum malaria in 2006. The World Health Organization (WHO) recommends regular assessment and monitoring of the efficacy of the first-line treatment, specifically considering that artemisinin resistance has been confirmed in the Greater Mekong sub-region. This study's main aim was to assess the efficacy and safety of AL for treating uncomplicated P. falciparum malaria in Tanzania.

Methods
This was a single-arm prospective antimalarial drug efficacy trial conducted in four of the eight National Malaria Control Programme (NMCP) sentinel sites in 2019. The trial was carried out in outpatient health facilities in Karume-Mwanza region, Ipinda-Mbeya region, Simbo-Tabora region, and Nagaga-Mtwara region. Children aged six months to 10 years with microscopy confirmed uncomplicated P. falciparum malaria who met the inclusion criteria were recruited based on the WHO protocol. The children received AL (a 6-dose regimen of AL twice daily for three days). Clinical and parasitological parameters were monitored during follow-up over 28 days to evaluate drug efficacy.

Results
A total of 628 children were screened for uncomplicated malaria, and 349 (55.6%) were enrolled between May and September 2019. Of the enrolled children, 343 (98.3%) completed the 28-day follow-up or attained the treatment outcomes. There were no early treatment failures; recurrent infections during follow-up were common at two sites (Karume 29.5%; Simbo 18.2%). PCR-corrected adequate clinical and parasitological response (ACPR) by survival analysis to AL on day 28 of follow-up varied from 97.7% at Karume to 100% at Ipinda and Nagaga sites. The commonly reported adverse events were cough, skin pallor, and abdominal pain. The drug was well tolerated, and no serious adverse event was reported.

Conclusion
This study showed that AL had adequate efficacy and safety for the treatment of uncomplicated falciparum malaria in Tanzania in 2019. The high recurrent infections were mainly due to new infections, highlighting the potential role of introducing alternative artemisinin-based combinations that offer improved post-treatment prophylaxis, such as artesunate-amodiaquine (ASAQ).
Practical Algorithms with Guaranteed Approximation Ratio for Traveling Tournament Problem with Maximum Tour Length 2
Authors: Zhao Jingyang , Xiao Mingyu 
Published: April 2024

The traveling tournament problem (TTP) is a hard but interesting sports scheduling problem inspired by Major League Baseball, which is to design a double round-robin schedule such that each pair of teams plays one game in each other’s home venue, minimizing the total distance traveled by all n teams (n is even). In this paper, we consider TTP-2 (i.e., TTP under the constraint that at most two consecutive home games or away games are allowed for each team). In this paper, we propose practical algorithms for TTP-2 with improved approximation ratios. Because of the different structural properties of the problem, all known algorithms for TTP-2 are different for n/2 being odd and even, and our algorithms are also different for these two cases. For even n/2, our approximation ratio is [Formula: see text], improving the previous result of [Formula: see text]. For odd n/2, our approximation ratio is [Formula: see text], improving the previous result of [Formula: see text]. In practice, our algorithms are easy to implement. Experiments on well-known benchmark sets show that our algorithms beat previously known solutions for all instances with an average improvement of 5.66%. Funding: This work was supported by the National Natural Science Foundation of China [Grants 62372095 and 62172077] and the Sichuan Natural Science Foundation [Grant 2023NSFSC0059].
Venous eczema: an update for nurses working in primary care
Authors: Nazarko Linda 
Published: April 2024

Venous eczema is one of the more common skin conditions seen by nurses in the UK, with the incidence set to rise as the population ages. Linda Nazarko details the best practice for diagnosis and management in a primary care setting Around 2 million people in the UK have venous eczema. The number of people with venous eczema is set to rise in line with population ageing, rising levels of obesity and falling levels of activity. Venous eczema is often under-recognised and poorly treated. This article outlines the causes of venous eczema, one of the complications of venous disease and how it can be managed.
A Method for Evaluating Global Navigation Satellite System Position Accuracy in Small Unmanned Aircraft Systems
Authors: Ladino Karla S. , Sama Michael Patrick 
Published: April 2024

HighlightsA novel UAS-based GNSS testing system was developed to assess both horizontal and vertical accuracy components.Recommendations are provided for further standard development related to UAS GNSS testing protocols.Future research can utilize this framework to enhance understanding of UAS GNSS accuracy. Abstract. Current standards for Global Navigation Satellite Systems (GNSS) testing are primarily designed for assessing horizontal positioning accuracy in ground-based applications. However, there is a notable absence of guidelines specifically addressing vertical accuracy assessment and applications that extend beyond ground-based scenarios, including those involving small unmanned aircraft systems (UAS). This effort aimed to develop a UAS-based GNSS testing system, tailored for the evaluation of GNSS receiver performance in dynamic low-altitude scenarios. The main objectives included (1) designing a GNSS testing system for UAS applications and (2) validating the system through field testing. The system development consisted of GNSS receiver configuration, data acquisition system design, processing procedures, and UAS payload and base station component design. The UAS payload featured multiple GNSS receivers operating in different modes, and data were collected using a custom Python script on a Raspberry Pi computer. For in-field validation, dynamic flight testing with vertical profiles was conducted. A robotic tracking total station (TTS) was used as the reference instrument for measuring the location of the UAS payload. The findings underscore the system's capabilities, primarily emphasizing its functionality rather than conducting an extensive assessment of the individual GNSS receiver performance. The UAS-based testing system that was developed was capable of satisfying most of the criteria for existing GNSS test standards. The insights derived from this process offer recommendations for standardizing UAS-based GNSS testing methods, with a particular focus on mission design, battery management, data processing, and environmental adaptability. Keywords: Dynamic Error, Global Navigation Satellite Systems (GNSS), Positioning Accuracy, Tracking Total Station (TTS), Unmanned Aircraft Systems (UAS).
Contrasting Male and Female Dietary Life Histories: A Case Study at an Ancestral Muwekma Ohlone Heritage Site in San Jose, California
Authors: Eerkens Jelmer W. , Tichinin Alina , Karapanos Nikoletta , Campbell-Grey Alexandra , Firenzi Alexandria M. , Bartelink Eric J. , Leventhal Alan M. , Arellano Monica V. , DeOrnellas Brieann 
Published: April 2024

ABSTRACT: Stable carbon and nitrogen isotope analyses of bones and teeth at the ancestral heritage Muwekma Ohlone site of Yakmuy ́Ooyákma-tka (“Place of the East Ridge Site”; CA-SCL-215) reveal significant differences in the dietary life history of males and females. Overall, isotope data indicate that site inhabitants were primarily dependent on low-trophic-level foods, likely plants, and minor amounts of marine food for their main source of dietary protein. From tooth dentin serial samples, we found that males and females were similar for δ13C in early childhood (age 1–9 years), but boys were elevated in δ15N by 0.6–1.0‰ relative to girls, indicating boys were accessing slightly greater amounts of higher-trophic-level foods, such as meat from game. The sex-biased difference in δ15N diminishes during the second decade of life, as female δ15N values increase and become equal to males. However, a difference in δ13C emerges during the second decade: female δ13C values are elevated relative to males. This could indicate that teenage females consumed higher amounts of low-trophic-level, marine-derived protein, such as shellfish. During later adult years the difference in δ13C disappears, while males again show an increase in δ15N relative to females. Although these differences are small, they reveal important sex-biased life history patterns during childhood and adulthood in this ancient community.
Italian places in Japanese manga: a study on topophilia in graphic narratives
Authors: Ursini Francesco-Alessio , Samo Giuseppe 
Published: April 2024

Abstract
The goal of this paper is to offer an analysis on how Italian places act as key narrative units in Japanese manga. Building on a quantitative and qualitative corpus study, the paper investigates how culturally salient locations are embedded in these narratives. It is first shown that authors develop salient locations (“places”) as distinct entities playing key roles within narrative structures. It is then shown that these representations of places follow principles of cultural relevance, popularity, historical and geographical faithfulness. This is the case because authors creating manga set in Italy share knowledge and appreciation of Italian places and their cultural import with readers. These results are framed in a theory of geo-criticism and in a possible worlds analysis of places in fiction, hereby extended to graphic narratives.
Glucagon-like peptide (GLP)-1 regulation of lipid and lipoprotein metabolism
Authors: Hoffman Simon , Adeli Khosrow 
Published: April 2024

Abstract
Metabolic health is highly dependent on intestinal and hepatic handling of dietary and endogenous lipids and lipoproteins. Disorders of lipid and lipoprotein metabolism are commonly observed in patients with insulin resistant states such as obesity, metabolic syndrome, and type 2 diabetes. Evidence from both animal models and human studies indicates that a major underlying factor in metabolic or diabetic dyslipidemia is the overproduction of hepatic and intestinal apolipoprotein (apo)B-containing lipoprotein particles. These particles are catabolized down into highly proatherogenic remnants, which can be taken up into the arterial intima and promote plaque development. Several gut-derived peptides have been identified as key regulators of energy metabolism; one such peptide is the incretin hormone glucagon-like peptide (GLP)-1. Our laboratory has previously demonstrated that GLP-1 can signal both centrally and peripherally to reduce postprandial and fasting lipoprotein secretion. Moreover, we have demonstrated that GLP-1 receptor (GLP-1R) agonists can ameliorate diet-induced dyslipidemia. Recently, we published evidence for a novel vagal neuroendocrine signalling pathway by which native GLP-1 may exert its anti-lipemic effects. Furthermore, we demonstrated a novel role for other gut-derived peptides in regulating intestinal lipoprotein production. Overall, ample evidence supports a key role for GLP-1R on the portal vein afferent neurons and nodose ganglion in modulating intestinal fat absorption and lipoprotein production and identifies other gut-derived peptides as novel regulators of postprandial lipemia. Insights from these data may support identification of potential drug targets and the development of new therapeutics targeting treatment of diabetic dyslipidemia.
Impact of clear aligners on plaque and periodontal health
Authors: Yadav Pramod Kumar , Verma Sanjeev Kumar , Bais Deepika Rajendra Singh , Singh Shriya 
Published: April 2024

In recent years, clear aligners have become a well-liked substitute for traditional braces in orthodontic treatment. Examining the effects of clear aligners on periodontal health and plaque accumulation is the goal of this review. To examine pertinent studies that have been published up to this point, a comprehensive evaluation of the literature was carried out. The review includes research on the microbial alterations in tooth plaque composition that occur during clear aligner therapy and the subsequent impact on periodontal tissues. Clear aligners and traditional braces are also compared with respect to how they affect gingival health, periodontal disease prevalence, and oral hygiene practices.In terms of plaque control, the results imply that transparent aligners offer special benefits and challenges. An important factor influencing the microbiological environment in the oral cavity is patient compliance, the type of aligner used, and the subtleties of its design. Moreover, the effect of orthodontic therapies on periodontal health is explored, providing insight into possible associations between the use of clear aligners and periodontal results. By underlining the necessity of individualized oral hygiene management strategies during clear aligner therapy, this review offers orthodontic practitioners’ insightful information. It highlights the need of maintaining periodontal health throughout orthodontic treatment and stresses the necessity of a multidisciplinary approach to optimize patient outcomes. In summary, this comprehensive review provides an overview of the most recent findings regarding the impact of clear aligners on plaque and periodontal health. By teaching clinicians, researchers, and patients about the subtleties of oral hygiene care during orthodontic treatment, the findings are meant to direct the development of effective strategies for maintaining good periodontal health in patients getting clear aligner therapy.