bluuebunny/crossref_metadata_2025_split huggingface dataset:
Therapy for Vitreous Seeding Caused by Retinoblastoma. A Review
Authors: Lapka Marek , Straňák Zbyněk 
Published: March 2024

Retinoblastoma is the most common primary malignant intraocular tumor in children. Seeding, specifically the dispersion of the tumor into the adjacent compartments, represents a major parameter determining the degree of retinoblastoma according to the International Classification of Retinoblastoma. In this article we focused on vitreous seeding, one of the main limiting factors in the successful “eye preservation treatment” of retinoblastoma. This article presents an overview of the history of vitreous seeding of retinoblastoma, established treatment procedures and new-research modalities. The introduction of systemic chemotherapy in the treatment of retinoblastoma at the end of the 1990s represented a significant breakthrough, which enabled the progressive abandonment of radiotherapy with its attendant side effects. However, the attained concentrations of chemotherapeutics in the vitreous space during systemic chemotherapy are not sufficient for the treatment of vitreous seeding, and the toxic effects of systemic chemotherapy are not negligible. A significant change came with the advent of chemotherapy in situ, with the targeted administration of chemotherapeutic drugs, namely intra-arterial and intravitreal injections, contributing to the definitive eradication of external radiotherapy and a reduction of systemic chemotherapy. Although vitreous seeding remains the most common reason for the failure of intra-arterial chemotherapy, this technique has significantly influenced the original treatment regimen of children with retinoblastoma. However, intravitreal chemotherapy has made the greatest contribution to increasing the probability of preservation of the eyeball and visual functions in patients with advanced findings. Novel local drug delivery modalities, gene therapy, oncolytic viruses and immunotherapy from several ongoing preclinical and clinical trials may represent promising approaches in the treatment of vitreous retinoblastoma seeding, though no clinical trials have yet been completed for routine use.
EVALUASI KOMPETENSI GURU DALAM PELATIHAN PADA MEDIA PLATFORM MERDEKA MENGAJAR DI SDN SUNGAI GAMPA ASAHI DAN SDN SUNGAI BAMBAN KABUPATEN BARITO KUALA
Authors: Bardiansyah Bardiansyah , Madihah Husnul , Susanto Didi 
Published: March 2024

Penelitian ini dengan tujuan (1) Mengetahui persiapan perencanaan pelaksanaan Implementasi Kurikulum merdeka pada SDN Sungai Gampa Asahi dan SDN Sungai Bamban (2) Pelaksanaan Implementasi Kurikulum merdeka di SDN Sungai Gampa Asahi dan SDN Sungai Bamban (3) Evalausi Pelaksanaan Kurikulum merdeka di SDN Sungai Gampa Asahi dan SDN Sungai Bamban.Jenis Penelitian yang digunakan adalah pendekatan kualitatif deskriptif dengan melibatkan kepala sekolah dan guru sebagai subjek penelitian. Data dikumpulkan melalui wawancara, observasi, dan analisis dokumen yang ada.Hasil Penelitian sebagai berikut, (1) Persiapan pelaksanaan kurikulum merdeka di SDN Sungai Gampa Asahi adalah dengan melaksanakan pelatihan mandiri menggunakan platform merdeka mengajar metode diskusi terbimbing, melibatkan Seluruh Guru dalam penyusunan Kurikulum Operasional Satuan Pendidikan (KOSP), sedangkan di SDN Sungai Bamban dimulai menyusun kurikulum yang relevan dengan pengalaman hidup sehari-hari siswa, mengadakan pelatihan mandiri dengan menggunakan platform merdeka mengajar metode workshop(2) Pelaksanaan Kurikulum merdeka di SDN Sungai Gampa Asahi dengan melibatkan peserta didik sesuai konsep merdeka mengajar, penerapan pembelajaran berdeferensiasi, sedangkan di SDN Sungai Bamban pelaksanaan kurikulum merdeka dengan melaksanakan pembelajaran berdeferensiasi, guru lebih mengutamakan keseimbangan antara proses yang baik dan mengahasilkan produk hasil belajar (3) Evaluasi Pelaksanaan kurikulum merdeka di SDN Sungai Gampa Asahi sudah sesuai dengan pelatihan mandiri menggunakan Platform Merdeka Mengajar untuk mendapatkan pemahaman konsep merdeka mengajar, evaluasi yang dilakukan kepala sekolah terhadap guru adalah dengan supervisi akademis, sedangkan di SDN Sungai Bamban Evaluasi pelaksanaan kurikulum merdeka dengan memastikan Konsep merdeka mengajar dapat melalui supervisi akademik, melakukan refleksi dan memberikan umpan balik dan tindak lanjut terhadap kegiatan pembelajaran.
PENINGKATAN PENGETAHUAN DAN KEBIASAAN SARAPAN PAGI SISWA MELALUI PROGRAM SARAPAN PAGI MUMULUK ISUK
Authors: Nursasi Astuti Yuni , Azwar Azwar , Runtulalo Fonny Veronika , Caroline Clara , Hidayah Asep Abdurrahman , Ayu Nita Yunita Sri 
Published: March 2024

Abstrak: Sarapan pagi merupakah hal yang sangat penting dan tidak boleh dilewatkan oleh anak usia sekolah sebelum memulai aktivitas di pagi hari, banyak dampak yang akan diakibatkan dari tidak sarapannya siswa di pagi hari seperti konsentrasi belajar menurun, peningkatan asam lambung dan tubuh akan merasa lemas yang secara tidak langsung akan menghambat prestasi. Tujuan dari pengabdian masyarakat ini adalah agar siswa mengetahui dan mampu untuk mempraktekkan kegiatan sarapan pagi sebelum ke sekolah di SDN Sukadamai 1 Bogor. Metode yang digunakan adalah Community Based Research (CBR). Dilakukan intervensi berupa program Sarapan Pagi Mumuluk Isuk yang diikuti oleh 56 siswa kelas VI. Hasil menunjukkan bahwa terjadi peningkatan pengetahuan siswa mengenai sarapan pagi sebelum ke sekolah. Rerata tingkat pengetahuan sebelum pelaksanaan program yaitu 6.17 dan rerata pengetahuan setelah pelaksanaan program yakni 8.82 sehingga dapat disimpulkan bahwa terjadi peningkatan pengetahuan siswa setelah pelaksanaan program.Abstract: Breakfast is a very important thing and should not be missed by school-age children before starting activities in the morning, many impacts will result from not having breakfast in the morning such as decreased learning concentration, increased stomach acid and the body will feel weak which will indirectly hamper achievement. The purpose of this community service is for students to know and be able to practice breakfast activities before going to school at SDN Sukadamai 1 Bogor. The intervention was conducted in the form of Sarapan Pagi Mumuluk Isuk programme which was attended by 56 grade VI students. The results showed that there was an increase in students' knowledge about breakfast before school. The mean level of knowledge before the implementation of the programme was 6.17 and the mean knowledge after the implementation of the programme was 8.82 so it can be concluded that there was an increase in student knowledge after the implementation of the programme.
Sensor event sequence prediction for proactive smart home: A GPT2-based autoregressive language model approach
Authors: Takeda Naoto , Legaspi Roberto , Nishimura Yasutaka , Ikeda Kazushi , Minamikawa Atsunori , Plötz Thomas , Chernova Sonia 
Published: March 2024

We propose a framework for predicting sensor event sequences (SES) in smart homes, which can proactively support residents’ activities and alert them if activities are not completed as intended. We leverage ongoing activity recognition to enhance the prediction performance, employing a GPT2-based model typically used for sentence generation. We hypothesize that the relationship between ongoing activities and SES patterns is akin to the relationship between topics and word sequence patterns in natural language processing (NLP), enabling us to apply the GPT2-based model to SES prediction. We empirically evaluated our method using two real-world datasets in which residents performed their usual daily activities. Our experimental results demonstrates that the use of the GPT2-based model significantly improves the F1 value of SES prediction from 0.461 to 0.708 compared to the state-of-the-art method, and that leveraging knowledge on ongoing activity can further improve performance to 0.837. Achieving these SES predictions using the ongoing activity recognition model required simple feature engineering and modeling, yielding a performance rate of approximately 80%.
Physical-chemical and biopharmaceutical research of ointments with cyminal
Authors: Коритнюк Р. С. , Кабачна А. В. , Соловйов С. О. , Трохимчук В. В. , Наумова М. І. 
Published: March 2024

Local wound treatment remains one of the most pressing problems of modern medicine. The effectiveness of local drug therapy with the use of various medications depends on the differentiated use of drugs depending on the phase of the wound process.
Taking into account modern wound treatment technologies, it is important to develop the composition and technology of an application drug (cream, ointment, gel) taking into account not only the phase of the wound process, but also the Time-concept component, in particular the ability of the drug to create an optimal moist environment and have antimicrobial properties, since the absence of infection in the wound is the basis for successful healing.
The aim of our study was to develop an optimal composition of ointment for wound treatment based on technological and physicochemical studies.
The rheological properties of the samples were studied using a Reotest-2 rotational viscometer (USA) with a water circulating heater. The structural viscosity was determined at a temperature of 20 ± 0,2 °C. Thermostatization was performed in the ITZH-0-03 thermostat.
The temperature was determined by a laboratory thermometer with a division price of 0,1 °C. The acid-base balance was determined potentiometrically according to the State Standard Form I. The pharmacokinetic parameters of the drug were determined by dialysis through a semipermeable membrane.
The experimental ointment is a non-Newtonian fluid. Its fluidity begins after a certain mechanical stress is applied, i.e., after the kinetic energy of the particles of the structural frame increases, which leads to the breakdown of bonds between its elements. The maximum destruction of the system occurs at a temperature of 40 °С. The experimental data showed that the pH of the ciminal ointment is in the range from 5,5 to 7.5, which is optimal for the treatment of infected wounds. The pharmacokinetic parameters of the drug were determined: reaction rate of release of active substances; reaction rate constants, half-life. The kinetic processes of ciminals release from the drug are described by the first-order equation.
The composition and technology of the ointment have been substantiated on the basis of experimental studies.
Chromatographic analysis of flavonoids and phenolic acids in the herb Ocimum sanctum L.
Authors: Шанайда М. І. , Черевко М. О. 
Published: March 2024

The genus Basil (Ocimum L.), which belongs to the Mint (Lamiaceae Martinov) family, includes more than 70 species and several subspecies of herbaceous plants and subshrubs. In wild nature, they are common on almost all continents in tropical and subtropical regions, less often in temperate climates. Holy basil (Ocimum sanctum L.) is most often used in folk medicine of various countries. The medicinal properties of this plant are determined mainly by the essential oil and polyphenols. As it is known, the chemical composition of plant raw materials can vary significantly depending on genetic characteristics (subspecies, chemotype) as well as on soil and climatic conditions during its cultivation.
This study aimed to determine the chromatographic profile of flavonoids and phenolic acids in the Ocimum sanctum herb during its cultivation in the conditions of the Ternopil Region (Ukraine). The aerial part of the studied plant was harvested at the beginning of flowering in the summer of 2023. The dried raw material was crushed and sifted through a sieve. The chromatographic profile of flavonoids and phenolic acids was determined by high-performance liquid chromatography (HPLC) using an Agilent Technologies 1200 chromatograph. The raw material was extracted using 80% methanol in an ultrasonic bath. Identification and quantitative analysis were carried out using solutions of standard samples of flavonoids and phenolic acids. Calibration was carried out by the method of external standards.
It was revealed that the Ocimum sanctum herb contains eight phenolic acids, among which hydroxycinnamic rosmarinic acid (10 453.48 μg/g) dominated. In general, the content of hydroxycinnamic acids in the raw material of the studied species was significantly higher than that of hydroxybenzoic acids. Among the six identified flavonoids, the highest content was determined for the flavanone neohesperidin (11 720.79 μg/g); the content of other flavonoids, in particular, flavonol derivatives (quercetin, rutin, quercetin-3-O-glycoside, kaempferol-3-O-glycoside) and flavone (luteolin) was significantly lower.
Considering the significant therapeutic potential of the predominant phenolic compounds, the planning of further pharmacological studies of phytosubstances based on the raw material of the studied species deserves attention.
Modern Bir Aile Cemaati: Köpek Dişi
Authors: Körük Türker 
Published: March 2024

Zygmunt Bauman “Cemaatler: Güvenli Olmayan Bir Dünyada Güvenlik Arayışı” isimli kitabında cemaat kavramını kolayca ulaşamayacağımız ama içinde yaşamayı çok arzu ettiğimiz bir dünya olarak tanımlar. Bu dünya, güvenlik arayışıyla sığındığımız fakat bir süre sonra güvenliğimizin bedelini özgürlüğümüzle ödediğimiz ikilemli bir yapıdır.
Yunan Yeni Dalgası’nın önemli yönetmenlerinden Yorgos Lanthimos’un ikinci uzun metraj filmi Köpek Dişi (Dogtooth, 2009), bu ikilemli yapının toplumdan izole bir ailede nasıl çözüldüğünü incelememize olanak tanır. Aile kavramının, öğrenilen ve öğretilen bilgilerle güvenli ve özgür bir yuvaya, doğuştan gelen güdülerle ise karanlık bir kutuya dönüştüğünü cemaat kavramı üzerinden açıklamaya çalışmak, aile ve cemaat kavramlarının ne denli benzer oluşumlar olduklarını gözler önüne sermeye ve cemaat oluşumunun aslında gönüllü bir aidiyetten daha farklı bir yapı olarak şekillendiğini göstermemize yardımcı olacaktır.
Bu metin nitel bir çalışma olup, önemli bir olguyu belirgin bir şekilde yansıtan ya da normal şartlar altında özel bir öneme sahip olan durumları nitelediğimiz kritik durum örneklemesi çerçevesinde Baumancı bir okuma bağlamında ele alınarak, son yıllarda ‘modern aile’ kavramı üzerine tartışma yaratmış en önemli filmlerden olan ve ‘aile’ tanımına yeni-farklı bir bakış açısı kattığını düşündüğümüz Dogtooth filmi üzerinden aile ve cemaat kavramlarını bağdaştırmayı hedeflemektedir.
Comparing Voice Related Quality of Life scores between fenestrated and speaking valve cannula users
Authors: Yanti Lisa Apri , Dewi Veni Rosita , Bahar Erial 
Published: March 2024

Background: Tracheostomy is a procedure that aims to maintain the airway so that air can enter the lungs and bypass the upper airway. Tracheostomy causes physiological changes, especially in terms of communication, which leads to reduced voice-related quality of life. Fenestrated tracheal cannula and speaking valve can assist patients in generating voice.
Objective: To compare the V-RQOL scores of the fenestrated tracheal cannula and speaking valve users.
Methods: Analytic observational study using a cross-sectional design. Data collection was done through interviews with the V-RQOL questionnaire guide. The study was conducted in September-December 2022 at the THTBKL Polyclinic of Dr. Mohammad Hoesin Hospital Palembang. Data were analyzed with IBM SPSS 26.
Results: 42 patients were using tracheal cannula, with 21 patients each with a fenestrated and speaking valve tracheal cannula. Patients with fenestrated tracheal cannula had lower quality of life in the physical, social, and total domains than those in the speaking valve group (poor QoL in the physical domain: 66.67% vs. 9.52%; social domain: 85.71% vs. 57.14%; total domain: 76.19% vs. 4.76%; p<0.001). From the multivariate analysis, the tracheal cannula type influenced the patient's quality of life was (p<0.001). The probability of someone with a fenestrated tracheal cannula will experience a poor QoL is 76.2%, while speaking valve is 4.7%.
Conclusion: The quality of life of patients with a fenestrated type of tracheal cannula is significantly lower than that of speaking valve tracheal cannula users in both the physical, social, and total domains as measured by the V-RQOL.
The Effect of Rice Husk Ash and Pineapple Leaf Fiber on Physical and Mechanical Properties of Concrete
Authors: Atikah Nisrina , Frida Erna , Nasution Yulianti 
Published: March 2024

This study used the cast-in-situ method to make concrete based on rice husk ash and pineapple leaf fiber. Rice husk ash and pineapple leaf fiber were used as the cement substitutes with different variations: 0%, 2.5%, 5%, and 7.5%. Parameters examined in this study included density, porosity, water absorption, flexural strength, and compressive strength using a universal testing machine and Material Testing equipment, which were then analyzed morphologically using SEM-EDX. The result showed a density of 2.510 × 103 − 2.451 × 103 kg/m3, porosity of 7.64 – 5.73 %, water absorption of 0.296 % – 0.243 %, compressive strength of 23.66 – 16.45 MPa, flexural Strength of 33.3 – 25.3 MPa. The morphological analysis showed that the rice husk ash and pineapple leaf fiber addition was responsible for the concrete's porous structure in this study has a porous structure. The EDX analysis result exhibited a high carbon percentage.
Rectification of what was stated in the edition Diwan Jaran Al, Oud Al, Nimeiri
Authors: Mohammed Asst.Prof Phd Hazem Fadel 
Published: March 2024

Our Arabic literature was full of poets in its long history, including our poet Gran Oud Al-Nimeiri, whose poetry was a model of good poetry in our Arab heritage, which led me to find some poetic verses scattered in the various sources of literature that missed the diwan investigator, where the verses of gran al-Oud Al-Nimeiri poetry by Nouri Hammoudi al-Qaisi were: 358 thirds of a hundred and fifty-eight verses.
In this way I found some poetic verses in the books of language, literature and history ... It is one of the origins of famous books that missed the edition of the diwan with the investigation of Dr. Nouri Hammoudi al-Qaisi, and before this realization there are those who turned to the diwan, where dr. Al-Qaisi was assigned to the Diwan al-Oud Al-Nimeiri, which included thirty-three verses, and dr. Radwan al-Najjar was also entitled to twenty-four verses, and he participated with Dr. Al-Qaisi in seventeen of them (and singled out seven).
Then came Professor Abbas Hani al-Jarakh to made a edihad in which he listed eleven verses, four of which were imported by Dr. Najjar before him, and he was singled out by seven.
I have found nineteen verses that have missed all those who preceded me in this field, and it seems that their miss of these verses is the lack of time to see books that have not reached the hands of virtuous investigators...
The speech of Imam Ali (peace be upon him) at the burial of Fatimah al-Zahra, a consolation for the soul and the eloquence of patience
Authors: Mukalf Prof. PhD Sawadi Farag 
Published: March 2024

Imam Ali addressed his oratory to the messenger of God and gave a salute and peace to him after he had completed Fatima Azzahraa's burial, nearby her father's tomb.
In this speech, Imam Ali adopted the style of grievance and soliloquy. His expressions referred to many meanings of sadness and suffering due to the loss of this virtuous wife.
This state reminded him of how he lost the messenger of God and how he did the mission of his bod-washing and burying him, stating that patience and reward will be taken into consideration by Alla owing to this painful loss. The influence of Quran was very clear in this abridged speech which expresses many meanings and indications with reference to the tyranny and aggression launched against the daughter of the messenger of Alla wich was considered the cause of her speedy following with her father and her departure from the world.
The effect of teaching Arabic grammar according to functional education in the achievement of female students fourth grade literary
Authors: Al-Husseini Lecture.Wesal Muayyad Khudair 
Published: March 2024

The issue of the weakness of female students in Arabic grammar is an obstacle that was and still exists, despite the large number of scientific studies that dealt with this phenomenon and tried to reduce it, but it still exists to this day.
The importance of Arabic language stems from its being the most important link between individuals and groups, and therefore nations are interested in teaching their languages because it is a tool for thinking and expression, and it is a tool of understanding and communication between man and his environment. It is compatible with the students’ perceptions and understanding, and the experience and knowledge that they are equipped with. Arabic language is an honorable language of great stature that no language in the world has reached, neither in its past, nor in its present, nor in its future, because God Almighty revealed through it the Noble Qur’an that came to all mankind.
Arabic language grammar is of great importance because it is the faithful fortress, as it protects the tongue from melody and works to straighten the students’ tongues, accustom them to accuracy and to the correct use of words and structures, train them to think continuously, and enable them to understand complex and ambiguous structures.
As for the importance of the functional method in teaching Arabic grammar, because it aims to address grammatical rules in educational situations, and targets the aspect of meaning and the linking of words to each other when performing their meanings.
The importance of grammatical rules and their distinct status is what prompts us to teach them in ways that appeal to requests, and the method of teaching is one of the most important problems of teaching Arabic grammar.
Keywords: Arabic Grammar, teaching, language, functional, method
Political developments in Sri Lanka (1945-1948) and the British position on it
Authors: Al-Fahad Assistant Prof. Maher Chasib Hatem 
Published: March 2024

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This study deals with the topic ( Political Developments in Sri Lanka 1945-1948 and the British position on it), During this era, Sri Lanka witnessed important political and constitutional changes that had a major role in achieving national independence, Although it was within the British Commonwealth system, but it got rid of largely from the restrictions of British colonialism. During this era, there was clear cooperation between most of the leaders of the national movement on the one hand, and the British authorities on the other .
This British-Sri Lankan cooperation has resulted in several results, the most important of which is a gradual progress in the political and constitutional status of Sri Lanka, On the basis of which Sri Lanka was transformed from a colony administered directly by the British Governor-General in Sri Lanka to a country that enjoys a large degree of independence, Its affairs are administered by the Sri Lankan Prime Minister supported by a Legislative National Assembly elected by the Sri Lankan people. This cooperation also led to a major shift in the course of the political process in Sri Lanka. For the first time in the country’s history, political parties with different ideologies and partisan approaches appeared. To organize the masses and work to guide them politically. During this stage, the country witnessed the drafting of the first constitution in the country’s history. The process of drafting and approving it went through several stages until it took its final form in 1946. This stage also marked the emergence of the first national legislative assembly elected by the Sri Lankan people. And in which the right to participate is granted to both men and women, and Sri Lanka may be the first British colony in Asia to hold elections of this kind.