bluuebunny/crossref_metadata_2025_split huggingface dataset:
“Did Hume Really Follow Berkeley”
Authors: Conroy Grapham P. 
Published: February 2009

The Bishop of Cloyne, George Berkeley, was the sort of philosopher who, although most genial himself, was quite apt to embroil opponents and critics of his time and of our own in long-lasting and sometimes unresolved controversies. In attacking the “infidel mathematicians”, the “minute philosophers” among the scientists, Berkeley initiated a controversy on behalf of religion by taking to task the theory of fluxions held by Sir Isaac Newton, his friends, and followers which, beginning with Berkeley's Analyst and replies to it by Jurin and Walton, was continued on over one hundred years by subsequent writers. Florian Cajori in his History of Mathematics, commenting on the affair has written:‘We must not neglect to express our appreciation of the fact that Berkeley withdrew from the controversy after he had said all that he had to say on his subject. Some of the debates that came later were almost interminable, because the participants continued writing even after they had nothing more to say.’
Moral Weakness
Authors: Evans Donald 
Published: February 2009

Discussions of moral weakness in recent and even not so recent ethics have generally neglected large areas of the moral life. In some cases, it may be argued, such neglect has been accidental in that the philosopher or philosophers concerned have set out to examine problems thrown up by a class or classes of actions without purporting to present an exhaustive account of moral weakness. In other cases such neglect is pernicious in that if not designed to protect a certain philosophical position it has by the doctrinaire delimitation of the range of examples considered had precisely that effect. This delimitation has often arisen out of unexamined presuppositions as to the nature of moral weakness. They are embodied in the following general framework suggested as an account not of some cases of weakness but of all cases:In a case of weakness a man does something that he knows or believes he should (ought) not do, or fails to do something that he knows or believes he should do, when the occasion and the opportunity for acting or refraining is present, and when it is in his power, in some significant sense, to act in accordance with his knowledge or belief.
Descartes' “Simple Natures”
Authors: Hartland-Swann John 
Published: February 2009

It is one of the unfortunate habits of great philosophers to leave behind them unclarified points of doctrine which give headaches to those anxious to view their systems as coherent wholes, and often lead to considerable confusion, or even contradiction, in attempts at critical exposition. An outstanding example of this is furnished by Descartes' treatment of “simple natures.”To interpret what Descartes really meant by simple natures as described in the Regulae ad directionem ingenii, and to integrate this with what he said in his published works (where they are not mentioned as such) is by no means an easy task—as the differing views of various critics clearly indicate. One has only to compare, say, the expositions of Chevalier, Boyce Gibson and Keeling to see that there is little unanimity of opinion as to the actual connotation of simple natures, their proper role in the Cartesian metaphysic, their terminological equivalents in the Meditations and Principles, and their ontological as opposed to epistemological status. Many critics, as Dr. Keeling complains, have seen fit “to discuss them when treating of his (Descartes') method, and omit all reference to them thereafter.” To make any comprehensive attempt to sort out this critical Verwirrung, however, would require considerable space. What I shall do here, therefore, will be to state the problem as simply as I can and then offer a solution in the light of the evidence available—although I admit that short of recalling Descartes from his grave there can be no final solution.
Minds, Machines and Godel:
Authors: George F. H. 
Published: February 2009

I Would like to draw attention to the basic defect in the argument used by Mr J. R. Lucas (Minds, Machines and Gödel, Philosophy, July 1961, p. 112).Mr Lucas there states that Gödel's theorem shows that any consistent formal system strong enough to produce arithmetic fails to prove, within its own structure, theorems that we, as humans (‘minds’), can nevertheless see to be true. From this he argues that ‘minds’ can do more than machines, since machines are essentially formal systems of this same type, and subject to the limitation implied by Godel's theorem.
Toynbee and his Critics
Authors: Birks G. A. 
Published: February 2009

New ideas are seldom received with moderation. When Spengler's Decline of the West appeared it was greeted with wild enthusiasm, which collapsed like a pricked bubble under criticism. Now that Toynbee, a generation later, has taken up the theme, there seems to be a determination not to be caught a second time. His critics have no wish to be unfair, and much of what they say is true enough; but to anybody who has a sympathetic understanding of what he is attempting most of it seems entirely irrelevant and misleading.Toynbee's critics fall broadly into two classes—those for whom he says too little, and those for whom he says too much. In the first class are those who complain that he does not define his civilizations, that he does not say whether he is for or against Christianity, or that he does not explain how the deterministic aspects of his results can be reconciled with his liberalism and his avowed belief in free will. Yet if Toynbee had given precise answers to these and other questions, if he had come forward with a cut-and-dried philosophical system, these same critics might well have been the first to complain that he was imposing a priori conceptions on the facts of history—a charge that has been made against every philosophy of history, and one which it is very difficult to refute. Surely we can respect the integrity of a historian who declines to go beyond the facts, or adopt opinions before compelled by the evidence.
Religious and Secular Statements
Authors: Mellor D. H. 
Published: February 2009

The relation between religious and scientific explanations of events and states of affairs has been the subject of much debate. For example, are the statements‘John's life was saved by surgery’‘John's life was saved in answer to prayer’in competition with each other and, if so, in what way? They do not seem to be rival causal explanations, nor are they straightforwardly contradictory. Yet each seems to cast doubt on the other, or at least to make it to some extent redundant.
Optimism
Authors: Boden Margaret A. 
Published: February 2009

The optimist may be secretly envied, but he is publicly despised. His pronouncements are regarded as expressions of simple-minded blindness or as cynical propaganda. Optimism is not regarded as intellectually respectable. It was not always so: there have been times when optimism was not merely considered worthy of rational argument, but was widely accepted by thinking men. Now, however, we react with a growing embarrassment to passages such as these:The time will therefore come when the sun will shine only on free men who know no other master but their reason;… All the causes that contribute to the perfection of the human race, all the means that ensure it must by their very nature exercise a perpetual influence and always increase their sphere of action … the perfectibility of man is indefinite.
Reimbursement systems, organisational forms and patient selection: Evidence from day surgery in Norway
Authors: MARTINUSSEN PÅL E. , HAGEN TERJE P. 
Published: February 2009

AbstractCream skimming can be defined as the selective treatment of patients that demand few resources while providing high economic refunds. We test whether cream skimming occurs after the introduction of DRG-based activity-based financing (ABF) in Norway in 1997 and if the problem further increased after the 2002 organizational reform when hospitals were turned into trusts. The DRG-system offers the same economic reimbursement for patients classified within day-surgical DRGs irrespective of whether the patient receives same-day treatment or in-patient care over several days. This provides potential for cream skimming and allows us to investigate cream skimming within the actual diagnoses. Patient data from the period 1999-2005 is analyzed. Waiting times are used as indicators of patient selection and analyzed as a function of severity within each diagnosis, controlling for age and gender of the patient, as well as institutional and time-dependent variables. The analysis gives some evidence of cream skimming in the first period of ABF, in particular within the lighter orthopaedic diagnoses. However, cream skimming does not increase after the 2002 organizational reform but is stable, and for some DRGs even reduced. The study indicates that cream skimming may occur if reimbursement systems are not particularly sophisticated. Softening of budget constraints after the hospital reform of 2002 may explain why cream skimming does not increase after the reform. However, further investigation into this mechanism is needed.
Some pain, no gain: experiences with the no-claim rebate in the Dutch health care system
Authors: HOLLAND J. , VAN EXEL N.J.A. , SCHUT F.T. , BROUWER W.B.F. 
Published: February 2009

AbstractTo contain expenditures in an increasingly demand driven health care system, in 2005 a no-claim rebate was introduced in the Dutch health insurance system. Since demand-side cost sharing is a very controversial issue, the no-claim rebate was launched as a consumer friendly bonus system to reward prudent utilization of health services. Internationally, the introduction of a mandatory no-claim rebate in a social health insurance scheme is unprecedented. Consumers were entitled to an annual rebate of ₠ 255 if no claims were made. During the year, all health care expenses except for GP visits and maternity care were deducted from the rebate until the rebate became zero. In this article, we discuss the rationale of the no-claim rebate and the available evidence of its effect. Using a questionnaire in a convenience sample, we examined people’s knowledge, attitudes, and sensitivity to the incentive scheme. We find that only 4% of respondents stated that they would reduce consumption because of the no-claim rebate. Respondents also indicated that they were willing to accept a high loss of rebate in order to use a medical treatment. However, during the last month of the year many respondents seemed willing to postpone consumption until the next year in order to keep the rebate of the current year intact. A small majority of respondents considered the no-claim rebate to be unfair. Finally, we briefly discuss why in 2008 the no-claim rebate was replaced by a mandatory deductible.
Dynamic hierarchies: a control system paradigm for exposure therapy
Authors: Brady Alec , Raines David 
Published: February 2009

AbstractExposure therapy is a widely used and well-evidenced treatment for a variety of avoidance behaviours. This paper offers a modest proposal for an improvement in how it is carried out (‘dynamic hierarchies’). The theoretical and practical context is set out, including some thoughts on the role of appraisals and cognitive dissonance, and some advantages of the method are suggested.
Coronary artery calcium distribution and interscan measurement variability in end-stage renal and coronary heart disease patients
Authors: Serafin Z. , Laskowska K. , Marzec M. , Sinjab T. A. , Lasek W. , Włodarczyk Z. 
Published: February 2009

Background: Coronary heart disease patients and end-stage renal disease patients have been documented to have an increased amount of coronary artery calcifications (CAC). Purpose: To evaluate the distribution of CAC and its influence on interscan variability of measurement in end-stage renal disease and coronary heart disease patients, proven to have calcifications. Material and Methods: 69 patients having CAC, including 34 with coronary heart disease and 35 with end-stage renal disease, were scanned twice with multidetector-row computed tomography (MDCT). Amount of CAC was determined as the number of calcified lesions (CN), total calcium score (CS), calcium volume (CV), and calcium mass (CM). Distribution of CAC was evaluated on a per-patient basis as the median CS and CM of a single lesion. Density of the calcifications was calculated as the patient's CM divided by CV. Results: The overall median CS was 457.2, and the median CM was 75.6 mg. There were no significant differences in the number of calcified lesions, CS, or CM between the two groups. Both CS and CM of a single lesion, as well as the mean calcium density were lower in renal disease patients ( P<0.05) than in coronary heart disease subjects. The relative interscan variability of coronary calcium measurement was higher in the renal disease group ( P<0.05). There was a negative correlation between the calcium concentration and the relative interscan variability. Conclusion: The results indicate that the coronary calcium distribution influences the measurement interscan reproducibility, and the distribution may differ between end-stage renal disease patients and coronary heart disease patients, reflecting the dissimilar nature of coronary calcifications in those groups.
Are there any specific ultrasound findings of nodular hyperplasia (“leave me alone” lesion) to differentiate it from follicular adenoma?
Authors: Moon Won-Jin , Kwag Hyon Joo , Na Dong-Gyu 
Published: February 2009

Background: Among benign thyroid nodules, nodular hyperplasia (NH) is the most common and represents a “leave me alone” lesion with no requirement for further treatment, while follicular adenoma (FA) is a lesion that should potentially be removed due to the difficulty of differentiation from a carcinoma on a biopsy alone. Purpose: To evaluate whether there are specific ultrasound (US) findings for an NH to distinguish it from an FA. Material and Methods: Pathologically proven cases of benign thyroid nodules (95 cases: 53 NH, 42 FA) were reviewed retrospectively. The number of associated nodules, the nodule size, internal content, shape, margin, echogenicity, presence of peripheral halo, and calcification were analyzed using grayscale ultrasonography. Results: NHs were predominantly solid in 40 cases (75.5%) and predominantly cystic in 13 cases (24.5%), while FAs were predominantly solid in all cases ( n=42, 100%) ( P<0.001). A spongiform appearance was present exclusively in NH (9/53, 17.0%). For NH, 83.0% of the lesions (44/53) showed an isoechoic pattern. For FA, the lesions showed a variable echoic pattern, including a marked hypoechoic pattern (5/42, 11.9%), a hypoechoic pattern (22/42, 52.4%), and an isoechoic pattern (15/42, 35.7%) ( P<0.001). The nodule size, shape, margin, presence of peripheral halo, and calcification did not show any difference between FA and NH. Conclusion: The ratio of solid to cystic content, spongiform appearance, and echogenicity is a combination of US findings that may be helpful in distinguishing an NH from an FA, and may thereby help to avoid unnecessary fine-needle aspirations for “leave me alone” lesions.
Hospital-Associated Clostridium difficile Infection: Is It Necessary to Track Community-Onset Disease?
Authors: Dubberke Erik R. , McMullen Kathleen M. , Mayfield Jennie L. , Reske Kimberly A. , Georgantopoulos Peter , Warren David K. , Fraser Victoria J. 
Published: February 2009

Objectives.To compare Clostridium difficile infection (CDI) rates determined with use of a traditional definition (ie, with healthcare-onset CDI defined as diagnosis of CDI more than 48 hours after hospital admission) with rates determined with use of expanded definitions, including both healthcare-onset CDI and community-onset CDI, diagnosed within 48 hours after hospital admission in patients who were hospitalized in the previous 30 or 60 days, and to determine whether differences exist between patients with CDI onset in the community and those with CDI onset in a healthcare setting.Design.Prospective cohortSetting.Tertiary acute care facility.Patients.General medicine patients who received a diagnosis of CDI during the period January 1, 2004, through December 31, 2005.Methods.CDI was classified as healthcare-onset CDI, healthcare facility–associated CDI after hospitalization within the previous 30 days, and/or healthcare facility-associated CDI after hospitalization within the previous 60 days. Patient demographic characteristics and medication exposures were obtained. The CDI incidence with use of each definition, CDI rate variability, patient demographic characteristics, and medication exposures were compared.Results.The healthcare-onset CDI rate (1.6 cases per 1,000 patient-days) was significantly lower than the 30-day healthcare facility–associated CDI rate (2.4 cases per 1,000 patient-days; P<.01) and the 60-day healthcare facility–associated CDI rate (2.6 cases per 1,000 patient-days; P<.01). There was good correlation between the healthcare-onset CDI rate and both the 30-day (correlation, 0.69; P<.01) and 60-day (correlation, 0.70; P<.01) healthcare facility–associated CDI rates. There were no months in which the CDI rate was more than 3 standard deviations from the mean. Compared with patients with healthcare-onset CDI, patients with community-onset CDI were less likely to have received a fourth-generation cephalosporin (P = .02) or intravenous vancomycin (P = .01) during hospitalization.Conclusions.Compared with the traditional definition, expanded definitions identify more patients with CDI. There is good correlation between traditional and expanded CDI definitions; therefore, it is unclear whether expanded surveillance is necessary to identify an abnormal change in CDI rates. Cases that met the expanded definitions were less likely to have occurred in patients with fourth-generation cephalosporin and vancomycin exposure.
Oocyte development in captive Atlantic horse mackerel Trachurus trachurus
Authors: Ndjaula Hilkka O. N. , Hansen Tom , Krüger-Johnsen Maria , Kjesbu Olav Sigurd 
Published: February 2009

Abstract
Ndjaula, H. O. N., Hansen, T., Krüger-Johnsen, M., and Kjesbu, O. S. 2009. Oocyte development in captive Atlantic horse mackerel Trachurus trachurus. – ICES Journal of Marine Science, 66: 623–630. This 13-month experimental study focused on developing oocyte production in 101 adult female Atlantic horse mackerel. In addition, proxies of energy patterns in relation to oocyte development were investigated. The fish were captured off western Norway and fed to satiation from October 2005 to November 2006 in two replicate adjacent circular tanks. Monthly histological examination of the ovaries indicated that vitellogenic oocytes were present at all times throughout the study period, but that oocyte development did not progress past the incipient migratory nucleus stage. The oocyte diameter (OD) threshold between pre-vitellogenic and vitellogenic oocytes and the mean OD of the leading cohort were investigated, and no hiatus was observed within the OD size distribution around the 185-µm pre-vitellogenic and vitellogenic threshold. Variation in gonadosomatic index, hepatosomatic index, condition factor, and fat content (as measured by the use of a Distell Fish Fatmeter) increased with oocyte development. The observed development of oocyte recruitment and the absence of a hiatus in the oocyte distribution are characteristics of an asynchronous spawner. The species seems to have a prolonged spawning season, judging from the advanced and variety of maturity stages throughout the study period.
The Cytosolic Protein Response as a Subcomponent of the Wider Heat Shock Response inArabidopsis
Authors: Sugio Akiko , Dreos René , Aparicio Frederic , Maule Andrew J. 
Published: February 2009

AbstractIn common with a range of environmental and biological stresses, heat shock results in the accumulation of misfolded proteins and a collection of downstream consequences for cellular homeostasis and growth. Within this complex array of responses, the sensing of and responses to misfolded proteins in specific subcellular compartments involves specific chaperones, transcriptional regulators, and expression profiles. Using biological (ectopic protein expression and virus infection) and chemical triggers for misfolded protein accumulation, we have profiled the transcriptional features of the response to misfolded protein accumulation in the cytosol (i.e., the cytoplasmic protein response [CPR]) and identified the effects as a subcomponent of the wider effects induced by heat shock. The CPR in Arabidopsis thaliana is associated with the heat shock promoter element and the involvement of specific heat shock factors (HSFs), notably HSFA2, which appears to be regulated by alternative splicing and non-sense-mediated decay. Characterization of Arabidopsis HSFA2 knockout and overexpression lines showed that HSFA2 is one of the regulatory components of the CPR.
Estrogen receptor α gene ESR1 amplification may predict endocrine therapy responsiveness in breast cancer patients
Authors: Tomita Saori , Zhang Zhenhuan , Nakano Masahiro , Ibusuki Mutsuko , Kawazoe Teru , Yamamoto Yutaka , Iwase Hirotaka 
Published: February 2009

Estrogen receptor (ER) α plays a crucial role in normal breast development and has also been linked to mammary carcinogenesis and clinical outcome in breast cancer patients. However, the molecular mechanisms controlling the expression of ERα are as yet not fully understood. Gene amplification is one of the important factors regulating protein expression. Recent studies on the amplification of the ESR1 gene, which encodes ERα, have presented conflicting data. Using fluorescence in situ hybridization and real‐time quantitative polymerase chain reaction analysis, we examined the ESR1 status in a series of breast cancer tissues and analyzed its clinical importance. ESR1 gene amplification and gain were found in 22.6 and 11.3% of samples, respectively, as determined by three‐dimensional fluorescence in situ hybridization assay. Moreover, ESR1 amplification and amplification plus gain were significantly negatively correlated with tumor size, number of positive lymph nodes, negative ERα, and positive human epidermal growth factor receptor 2 status. It has also been shown that ESR1 amplification strongly correlates with higher expression levels of ER protein and that patients with ESR1 amplification in their tumors apparently experience longer disease‐free survival than those without. Our data suggest that ESR1 amplification might prove to be helpful in selecting patients who may potentially benefit from endocrine therapy. (Cancer Sci 2009; 100: 1012–1017)