bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors Associated With Outcomes in Allogeneic Hematopoietic Cell Transplantation With Nonmyeloablative Conditioning After Failed Myeloablative Hematopoietic Cell Transplantation
Authors: Baron Frédéric , Storb Rainer , Storer Barry E. , Maris Michael B. , Niederwieser Dietger , Shizuru Judith A. , Chauncey Thomas R. , Bruno Benedetto , Forman Stephen J. , McSweeney Peter A. , Maziarz Richard T. , Pulsipher Michael A. , Agura Edward D. , Wade James , Sorror Mohamed , Maloney David G. , Sandmaier Brenda M. 
Published: August 2006

Purpose Several studies have investigated the feasibility of allogeneic hematopoietic cell transplantations (HCTs) after reduced-intensity conditioning in patients who experienced relapse after myeloablative HCT. Although most studies showed relatively low nonrelapse mortality (NRM) rates and encouraging short-term results, it has yet to be defined which patients would benefit most from these approaches. Patients and Methods We analyzed data from 147 patients with hematologic malignancies who experienced treatment failure with conventional autologous (n = 135), allogeneic (n = 10), or syngeneic (n = 2) HCT and were treated with HLA-matched related (n = 62) or unrelated (n = 85) grafts after conditioning with 2 Gy of total-body irradiation with or without fludarabine. Results Three-year probabilities of NRM, relapse, and overall survival were 32%, 48%, and 27%, respectively, for related recipients, and 28%, 44%, and 44%, respectively, for unrelated recipients. The best outcomes were observed in patients with non-Hodgkin's lymphoma, whereas patients with multiple myeloma and Hodgkin's disease had worse outcomes as a result of high incidences of relapse and progression. Being in partial remission (PR) or complete remission (CR) at HCT (P = .002) and developing chronic graft-versus-host disease (GVHD; P = .03) resulted in lower risks of relapse and progression. Factors associated with better overall survival were PR or CR (P = .01) and lack of comorbidity (P = .03) at HCT and absence of acute GVHD after HCT (P = .06). Conclusion Encouraging outcomes were seen with allogeneic HCT after nonmyeloablative conditioning in selected patients who had experienced relapse after a high-dose HCT, particularly in patients with non-Hodgkin's lymphoma. Results with unrelated grafts were comparable with results with related grafts.
Androgen Therapy Induces Muscle Protein Anabolism in Older Women
Authors: Sheffield-Moore Melinda , Paddon-Jones Douglas , Casperson Shanon L. , Gilkison Charles , Volpi Elena , Wolf Steven E. , Jiang Jie , Rosenblatt Judah I. , Urban Randall J. 
Published: August 2006

AbstractContext: Normal healthy men and women undergo a gradual loss of skeletal muscle mass and strength with advancing age. While androgens are protein anabolic in older men, the metabolic effects in older women are poorly understood.Objective and Design: The objective of this study was to determine whether oral administration of a synthetic derivative of testosterone [oxandrolone, Oxandrin (OX)] (7.5 mg orally twice daily for 14 d) to five older women (age, 65 ± 2 yr) would enhance skeletal muscle anabolic biomarkers including mixed muscle fractional synthetic rate (FSR), net phenylalanine balance, androgen receptor, and IGF-I protein expression at d 0, 5, and 14 of treatment. As a positive control, seven older men were examined after 14 d of OX (10 mg orally twice daily).Setting: The study was performed at the General Clinical Research Center.Results: Fourteen days of OX significantly increased skeletal muscle FSR in older women (d 0, 0.073 ± 0.006 vs. d 5, 0.092 ± 0.006 vs. d 14, 0.115 ± 0.007%/h) (P &lt; 0.05, d 0 vs. d 14). Conversely, OX stimulated FSR in older men after only 5 d (d 0, 0.061 ± 0.003 vs. d 5, 0.101 ± 0.01 vs. d 14, 0.084 ± 0.01%/h) (P &lt; 0.05, d 0 vs. d 5). Androgen receptor expression was significantly increased in older men by d 14, but had not increased in older women. No change was noted in IGF-I expression in either group. We conclude that the skeletal muscle of older women and men responds to androgen administration, although the time course of anabolism appears to be gender specific.
Functional Significance of Polycystic-Size Ovaries in Healthy Adolescents
Authors: Mortensen Monica , Rosenfield Robert L. , Littlejohn Elizabeth 
Published: August 2006

AbstractContext: The relevance of adult polycystic ovary criteria to adolescence is unclear.Objective: The objective was to determine the functional significance of polycystic-size ovaries (PSO) in healthy adolescents.Design/Setting/Participants/Interventions: Healthy 11- to 18-yr-old postmenarcheal volunteers (n = 22) were recruited and divided into groups with normal size ovaries (VNSO; n = 10) or a polycystic-size ovary (VPSO; n = 12). They were secondarily compared with adolescents with polycystic ovary syndrome (PCOS; n = 8) matched for gynecological age and a PSO. All underwent GnRH agonist (GnRHag), oral glucose tolerance, and ACTH1–24 testing in our General Clinical Research Center.Results: VPSO had a higher peak 17-hydroxyprogesterone (17PROG) response to GnRHag than VNSO (146 ± 14 ng/dl, mean ± sem, vs. 85 ± 11; P = 0.008), as well as larger ovaries (13.3 ± 0.7 cc vs. 8.5 ± 0.8 cc). VPSO peak 17PROG was elevated (&gt;137 ng/dl) in 42% (5 of 12). However, VPSO and VNSO androgen levels were similar, with the exception of one VPSO subject who had hyperandrogenemia and thus met criteria for PCOS. VPSO were similar to VNSO in LH, FSH, estradiol, and adrenal androgenic function. Although the VPSO group resembled the PCOS group in their 17PROG response to the GnRHag test, they differed in having significantly smaller ovaries and lower body mass index and in lacking evidence of peripheral androgen excess and of insulin resistance.Conclusion: A PSO in asymptomatic adolescents seems typically to be a normal variant. However, about half have a subclinical PCOS type of ovarian dysfunction; it is unknown whether this indicates a genetic carrier state or a risk for anovulation.
Assessment of Adrenal Reserve in Pregnancy: Defining the Normal Response to the Adrenocorticotropin Stimulation Test
Authors: Suri Daesman , Moran Jill , Hibbard Judith U. , Kasza Kristen , Weiss Roy E. 
Published: August 2006

Abstract
Context: Normal pregnancy is a state of hypercortisolism, making adrenal insufficiency difficult to diagnose.
Objective: We sought to identify a normative, minimum-response threshold for the ACTH stimulation test in pregnancy. We hypothesized that salivary free cortisol (SaFC) would prove a more physiological and less variable measure of adrenal reserve in pregnancy than serum cortisol (SC).
Design: This is a prospective study of normal controls.
Setting: The study was conducted in an obstetrical clinic in a tertiary care hospital.
Patients: Patients included 36 healthy ambulatory pregnant women (aged 18–37 yr) with singleton pregnancies.
Intervention: The 250-μg ACTH stimulation test was performed in the healthy pregnant volunteers. Based on their gestational age at the time of recruitment, women were studied in one of the trimesters and were restudied at 11–14 wk postpartum.
Main Outcome Measures: Total SC, aldosterone, and SaFC concentrations were measured before and after ACTH. The response in pregnancy was compared with postpartum values.
Results: Basal SC (P = 0.01), aldosterone (P = 0.001), and SaFC (P = 0.01) values progressively increased during the trimesters of pregnancy and decreased postpartum, confirming that pregnant women have increased basal glucocorticoid and mineralocorticoid production. There was enhanced responsiveness of the maternal adrenal glands to ACTH stimulation as pregnancy progressed, as measured by peak stimulated SaFC (P = 0.009) and aldosterone (P = 0.01). In the milieu of altered binding globulins, SaFC is a more consistent, binding-globulin-independent measure of stimulated adrenal function than total SC. Minimum criteria for the normal SaFC response to ACTH stimulation in the second and third trimesters of pregnancy and postpartum have been generated based on a predominantly African-American group of subjects.
Conclusions: Reliable data are available for the evaluation of the adrenal axis in pregnancy with a noninvasive, outpatient measure of SaFC. Glucocorticoid therapy in pregnancy should take into account that adrenal reserve increases as pregnancy progresses.
Estradiol and Regulation of Anti-Müllerian Hormone, Inhibin-A, and Inhibin-B Secretion: Analysis of Small Antral and Preovulatory Human Follicles’ Fluid
Authors: Andersen Claus Yding , Byskov Anne Grete 
Published: August 2006

AbstractContext: In ovaries surgically removed for fertility preservation, hormone concentrations in fluid from small antral follicles were determined. Levels were compared with those found in preovulatory follicular fluid.Objective: The objective of this study is to measure intrafollicular concentrations of anti-Müllerian hormone (AMH), inhibin-A, inhibin-B, estradiol, and progesterone.Setting: The study was set in a university hospital.Patients: Patients were 22 women suffering from a cancer disease and 16 women undergoing assisted reproduction.Interventions: Fluid from 35 follicles (diameter, 3–8 mm) was included and compared with that of 32 preovulatory follicles.Main Outcome Measures: The main outcome measures were intrafollicular concentrations of the measured hormones and their possible correlation.Results: Concentrations of AMH in small antral follicles were almost three orders of magnitude higher than in follicle fluid of preovulatory follicles, 790 ± 95 vs. 1.17 ± 0.14 ng/ml (mean ± sem), respectively. There was a significant negative correlation between estradiol and AMH in fluid from small antral follicles, whereas inhibin-A and inhibin-B were correlated positively with estradiol concentrations. Progesterone showed a similar correlation to levels of AMH but only in fluid of preovulatory follicles.Conclusions: The high expression of AMH in granulosa cells of small antral follicles actually translates into very high follicle fluid AMH concentrations. This most likely explains the correlation between serum AMH levels and the number of small antral follicles as previously demonstrated. The negative correlation between estradiol and AMH suggests that FSH down-regulates AMH expression. Thus, the microenvironment of the follicle shows profound changes with developmental stage and highlights the importance of studies to understand the mechanisms that regulate follicular growth and development during antral stages of development.
Radioactive Iodine Therapy for Goitrous Hashimoto’s Thyroiditis
Authors: Tajiri Junichi 
Published: August 2006

Abstract
Context: Hashimoto’s thyroiditis is an autoimmune disease that can produce marked clinical symptoms when patients have large diffuse goiters.
Design: This retrospective cohort study was designed to evaluate whether radioactive iodine (RAI) is effective for Hashimoto’s thyroiditis with a large goiter. Starting in November 1999, 13 Hashimoto’s patients with large goiters, whose thyroiditis was refractory to TSH suppression therapy with thyroid hormone administration [two men and 11 women with a mean age of 61.2 ± 8.9 yr (50–79 yr)], were recruited for the present study. The duration of symptomatic goiter before undergoing RAI was 12.0 ± 7.9 yr (4–33 yr). Thirteen millicuries of 131I was administered two to six times, at an interval of 1–6 months on an outpatient basis. Thyroid weight was measured ultrasonographically, or by computed tomography if ultrasound was not possible due to the large size of the goiter.
Results: RAI was administered an average of 4.7 ± 1.4 times (two to six times), with a total dose of 59.8 ± 17.3 mCi (25.0–78.0 mCi). The observation period was 47.9 ± 13.4 months (26–66 months) after the first RAI. The average weight of the thyroid gland was 125.3 ± 57.7 g (42.9–269.4 g) before the first RAI, decreasing significantly to 49.7 ± 25.8 g (18.3–93.3 g) after the last RAI (P &lt; 0.001, paired Student’s t test). The percent reduction from baseline was 58.7 ± 14.2% (35.7–84.0%). None of the patients showed an increase in goiter size or complained of a pressure sensation after any of the RAI treatments.
Conclusion: RAI is effective in Hashimoto’s thyroiditis with a large goiter.
Kinematic Viscosities of 1,2-Ethanediol/1,4-Dioxane Binary Mixtures from −10 to +80 °C
Authors: Corradini Fulvio , Marcheselli Luigi , Tassi Lorenzo , Tosi Giuseppe 
Published: August 2006

Abstract
Mixture kinematic viscosities (ν) were measured for the 1,2-ethanediol/1,4-dioxane binaries, covering the whole miscibility field (0 ≤ X1 ≤ 1), at 19 temperatures ranging from −10 to +80 °C. The experimental ν values were fitted by different equations, such as Grunberg–Nissan, McAllister, Auslander, Heric, and polynomial one, using pure component properties for the binaries studied. A comparison of the calculated and experimental data shows that all the selected equations can be safely employed to predict the dependence of ν on the composition and on the temperature of the system studied when no binary experimental data are available.
Multiple Pulse Excitation of Molecular Vibration in Resonant Pump-Probe Experiments. I. Perturbative Approach
Authors: Kawashima Hitoshi , Shida Tadamasa 
Published: August 2006

Abstract
The possibility of stepwise amplification of molecular vibration by resonant multiple pulse excitation is theoretically considered on the basis of perturbation theory. A grating experiment favorable to its observation is proposed. It has proved that the effective interval of the repetitive irradiation to attain large amplitude vibrations is equal to odd halves of the period of the vibrational cycle and that there is no gain with an interval equal to the integral multiples of the vibrational period while such an interval is effective in mode selective excitation. It has also proved that the dispersed signal shifts periodically over a range of energy and that the range is widened as the vibrational amplitude is increased.
Interaction of Sodium 4′-(Butylamino)azobenzene-4-sulfonate with 2-(Octylsulfinyl)ethanol in Adsorbed Film and Micelle
Authors: Tanaka Fudeko , Harada Yuzo , Todoroki Natsuko , Aratono Makoto , Motomura Kinsi 
Published: August 2006

Abstract
The surface tension of the aqueous solution of anionic dye and nonionic surfactant mixture was measured as a function of total concentration at various compositions and at 298.15 K under atmospheric pressure. The dye used is sodium 4′-(butylamino)azobenzene-4-sulfonate (SBAS) and the nonionic surfactant is 2-(octylsulfinyl)ethanol (OSE). By use of thermodynamic relations developed previously, the phase diagrams of adsorption and micelle formation were constructed. It was found that SBAS and OSE are completely miscible with each other in the adsorbed film and that the adsorbed film is enriched in OSE compared with the solution except for a composition close to pure OSE. It was concluded that SBAS and OSE interact attractively with each other in the adsorbed and micellar states and, furthermore, that the interaction is more attractive in the micelle than in the adsorbed film. The miscibility of dye and nonionic surfactant is suggested to play an important role in the working of nonionic surfactant as a levelling agent in dyeing process.
Enantiometric Separation with Use of Stationary Phase Coated with Micellar Bile Salt for Microcolumn Liquid Chromatography
Authors: Hu Wenzhi , Haraguchi Hiroki 
Published: August 2006

Abstract
A novel method for enantiometric separation using an ODS stationary phase coated with bile salt micelles in high-performance liquid chromatography has been developed, where bile salt surfactants such as sodium cholate and sodium deoxycholate were used for micelle formation. The present method was applied to the separation of the enantiomers of 1,1′-binaphthyl-2,2′-diyl hydrogenphosphate (BNDHP) and N-dansylphenylalanine by using acetonitrile–water solution as the mobile phase. The dependence of the capacity factors and separation factors on the acetonitrile concentration in the mobile phase was examined for BNDHP enantiomers. These factors decreased with increasing acetonitrile concentration, which resulted in the change of separation characteristics of BNDHP enantiomers. Although BNDHP and N-dansylphenylalanine enantiomers were separated, similar enantiomers such as 2,2′-dihydroxy-1,1′ -binaphthyl and other N-dansylamino acids were not separated in the present separation system.
Syntheses and Spectral Properties of Dinitrosylmolybdenum(0) and Dioxomolybdenum(VI) Complexes
Authors: Maurya Mannar R , Gopinathan Changaramponnath 
Published: August 2006

Abstract
Syntheses of dinitrosylmolybdenum(0) complexes of Schiff bases derived from salicylaldehyde, 5-chlorosalicylaldehyde, o-hydroxyacetophenone, and p-nitrobenzoylhydrazide have been carried out in one step by the reaction of [Mo(acac)2(NO)2] (acacH = acetylacetone) and the Schiff bases. The complexes are of the type [Mo(LH)2(NO)2] (LH2 = Schiff base) in which Schiff bases behave as monobasic bidentate ligands and coordinate to molybdenum through the azomethine nitrogen and enolic oxygen of the hydrazide moiety after deprotonation. Two geometrical isomers with nitrosyl groups trans to each other have been noticed in solution. Dioxomolybdenum(VI) complexes of the above Schiff bases have also been synthesized using [MoO2(acac)2] as precursor for comparison.
Syntheses and Structures of NiS2N2 Compounds. [N,N′-Bis(o-mercaptobenzyliden)ethylenediaminato]nickel(II), Ni(tsalen), and [N,N′-Bis(o-mercaptobenzyl)ethylenediaminato]nickel(II), Ni(ebmba)
Authors: Yamamura Takeshi , Tadokoro Makoto , Tanaka Koji , Kuroda Reiko 
Published: August 2006

Abstract
The syntheses, structures, absorption spectra, and redox potentials of Ni(tsalen), H2tsalen = N,N′-bis(o-mercaptobenzyliden)ethylenediamine, and Ni(ebmba), H2ebmba = N,N′-bis(o-mercaptobenzyl)ethylenediamine, are described. Ni(tsalen) was prepared directly from N,N′-bis(o-t-buthylthiobenzyliden)ethylenediamine, from which H2ebmba and, subsequently, Ni(ebmba) were also prepared. The crystal data for these two complexes are as follows: 1) Ni(tsalen); space group Pna21 with the unit-cell dimensions a = 8.929(1), b = 22.603(2), c = 7.484(1) Å, Z = 4, 2) Ni(ebmba); space group P21/c, a = 13.324(5), b = 7.9263(8), c = 15.262(3) Å, β = 101.23(2)°. Ni(tsalen) and Ni(ebmba) adopt squareplanar geometries with average Ni–S distances of 2.157 and 2.165 Å, respectively. The Ni–N distances of these complexes are 1.85(5) and 1.945 Å, respectively. These values, as well as the redox potentials and absorption maxima, ware compared with those of another type of NiS2N2 compound, [Ni(ebtsa)]2−; H4ebtsa = N,N′-bis(o-mercaptobenzoyl)ethlenediamide.
Epimerization-Crystallization Method in Optical Resolution of 2,2′-Dihydroxy-1,1′-binaphthyl, and Kinetic Study
Authors: Kawashima Masatoshi , Hirata Reiko 
Published: August 2006

Abstract
Optical resolution of 2,2′-dihydroxy-1,1′-binaphthyl (1) with (R,R)-1,2-cyclohexanediamine (2) in toluene yielded optically pure (R)-1 in a yield of 160% based on the theoretical amount of the enantiomer contained in the racemate by selective crystallization of a less soluble complex, (R)-1·(R,R)-2, and epimerization of more soluble complex, (S)-1·(R,R)-2. Also optically pure (S)-1 was obtained with the same enantiomer of the resolving agent, (R,R)-2, in a yield of 154%. (R,R)-1,2-Diphenyl-1,2-ethanediamine (3) was a suitable resolving agent for both 1 and 6,6′-dibromo-2,2′-dihydroxy-1,1′-binaphthyl. Kinetic study indicated that the reversible first-order rate constants for the epimerizations of (S)-1·(R,R)-2 and (S)-1·(R,R)-3 were larger than that for the racemization of (S)-1. The activation energy and frequency factor for the epimerization of (S)-1·(R,R)-2 were 109 kJ mol−1 K−1 and 3 × 1010 s−1, respectively, and those for (S)-1·(R,R)-3 were 96 kJ mol−1 K−1 and 1 × 108 s−1, while those for the racemization of (S)-1 were 85 kJ mol−1 K−1 and 9 × 105 s−1, respectively.
Solid Acid and Base-Catalyzed Cyanosilylation of Carbonyl Compounds with Cyanotrimethylsilane
Authors: Higuchi Katsumi , Onaka Makoto , Izumi Yusuke 
Published: August 2006

Abstract
A new attempt was investigated to utilize inorganic solid acids and bases for the promotion of the reaction of cyanotrimethylsilane (Me3SiCN) with carbonyl compounds. Strongly acidic solids, such as Sn4+ ion-exchanged montmorillonite (Sn-Mont) and Fe3+ ion-exchanged montmorillonite (Fe-Mont), as well as basic solids, such as calcium fluoride (CaF2), hydroxyapatite (HAp), calcium oxide (CaO), and magnesium oxide (MgO), catalyzed the reaction of Me3SiCN with aldehydes and ketones to afford the corresponding 2-(trimethylsiloxy)alkanenitriles in good yields. The reactions of dimethyl acetals with Me3SiCN in the presence of solid acids afforded 2-methoxyalkanenitriles. In cyanosilylations of α,β-unsaturated ketones two kinds of adducts were produced selectively, depending on the use of a solid acid or a solid base: 1,4-Adducts (trimethylsilyl enol ether forms) were selectively obtained in the presence of strong solid acids, such as Fe-Mont and Sn-Mont, while 1,2-adducts (trimethylsilyl ether forms) were predominantly formed in the presence of solid bases, such as HAp, CaO, and MgO. The solid acids and bases realized higher activities and selectivities in the cyanosilylation than did conventional homogeneous catalysts.
A Base-Catalyzed H/D Exchange Reaction in the 6-(1-Pyridinio)-6-deoxy Derivatives of Cyclodextrins
Authors: Mu Ping , Fujie Masahiko , Matsui Yoshihisa 
Published: August 2006

Abstract
Mono[6-(1-pyridinio)-6-deoxy]-α-cyclodextrin and its analogs exchanged the α-hydrogens of their pyridinio moieties with the deuteriums of solvent D2O in an alkaline buffer solution via the formation of the pyridinium ylide intermediates. The H/D exchange reaction was facilitated by the hydrophobic cavity of cyclodextrin, as well as by a substitution of the additional pyridinio group for the primary OH group, especially in the adjacent glucopyranose moiety of the cyclodextrin residue. On the other hand, the reaction was moderately retarded by an increase in the ionic strength of the solution, and markedly retarded by inorganic anions, such as I−, SCN−, and ClO4−, which were strongly bound to the cavity of cyclodextrin.
Syntheses and Structures of 1,1-Dimethyl-1,2,6,10b-tetrahydro-6,10b-o-benzenoaceanthrylenes: Sterically Congested Triptycenes Carrying Five-Membered Ring
Authors: Toyota Shinji , Endo Masahiko , Teruhi Mitsuru , Noda Yoshiyuki , Oki Michinori , Yamasaki Mikio , Shibahara Takashi 
Published: August 2006

Abstract
Sterically compressed title compounds which carry a five-membered ring condensed to the triptycene skeleton were synthesized by the Diels-Alder reaction of 1,1-dimethyl-1,2-dihydroaceanthrylene with a benzyne. The structures of three compounds were determined by X-ray crystallography. The molecules have several abnormal bond lengths and angles in addition to significant deformation of the benzene rings as well as the triptycene skeleton to avoid the eclipsed conformation about C(1)–C(10b) and C(1)–C(2) bonds. The effects of the substituents at the 7—10 positions are rather small, but an interesting bond angle deformation is found on comparison of the C(10a)–C(10)–substituent bond angles. Molecular mechanics calculation was performed for the dimethoxy compound to compare the calculated structure with the X-ray structure. Molecular flexibility of the unsubstituted compound was discussed on the basis of MM2 calculation.