bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Gene Expression Profiles in Thyroid Nodule Biopsy Material to Diagnose Thyroid Cancer
Authors: Durand Stéphanie , Ferraro-Peyret Carole , Selmi-Ruby Samia , Paulin Christian , El Atifi Michelle , Berger François , Berger-Dutrieux Nicole , Decaussin Myriam , Peix Jean-Louis , Bournaud Claire , Orgiazzi Jacques , Borson-Chazot Françoise , Rousset Bernard 
Published: January 2008

Abstract
Context: Detection of thyroid cancer among benign nodules on fine-needle aspiration biopsies (FNAB), which presently relies on cytological examination, is expected to be improved by new diagnostic tests set up from genomic data.
Objective: The aim of the study was to use a set of genes discriminating benign from malignant tumors, on the basis of their expression levels, to build tumor classifiers and evaluate their capacity to predict malignancy on FNAB.
Design: We analyzed the level of expression of 200 potentially informative genes in 56 thyroid tissue samples (benign or malignant tumors and paired normal tissue) using nylon macroarrays. Gene expression data were subjected to a weighted voting algorithm to generate tumor classifiers. The performances of the classifiers were evaluated on a series of 26 sham FNAB, i.e. FNAB carried out on thyroid nodules after surgical resection.
Results: A series of 19 genes with a similar expression in follicular adenomas and normal tissue and discriminating follicular adenomas+normal tissue from the following: 1) follicular thyroid carcinomas (FTCs), 2) papillary thyroid carcinomas (PTCs), or 3) both FTCs and PTCs. These were used to generate four classifiers, the FTCs, PTCs, common (FTC+PTCs), and global classifiers. In 23 of the 26 sham FNAB, the four classifiers yielded a diagnosis in agreement with the diagnosis of the pathologist used as reference; in the three other cases, the correct diagnosis was given by three of four classifiers.
Conclusions: We developed a procedure of molecular diagnosis of benign vs. malignant tumors applicable to the material collected by FNAB. The molecular test complied with a preclinical validation stage; it must be now evaluated on ultrasound-guided FNAB in a large-scale prospective study.
Photochemical and Photophysical Characteristics in the Excited State Properties of Methoxy-substituted Enediynes
Authors: Yoshimura Nao , Momotake Atsuya , Shinohara Yoshihiro , Nishimura Yoshinobu , Arai Tatsuo 
Published: January 2008

Abstract
Effects of methoxy substituent on the phenyl ring of cis isomer of enediynes were explored. All the cis isomers exhibited fluorescence emission with moderate efficiency. Furthermore, the ortho-substituted compounds showed red shift of the fluorescence emission even though crystallographic analysis suggests that the single bond connecting the phenyl ring and carbon–carbon triple bond takes considerably twisted conformation.
Sensitivity of Magnetic Resonance Imaging in the Detection of Colorectal Liver Metastases
Authors: Blyth S , Blakeborough A , Peterson M , Cameron IC , Majeed AW 
Published: January 2008

INTRODUCTION The aim of this study was to evaluate the sensitivity of magnetic resonance imaging (MRI) in the detection of colorectal liver metastases. PATIENTS AND METHODS Pre-operative MRI scanning of the liver was performed by a single radiologist and the size and number of definite liver metastases were recorded. Patients then underwent hepatectomy with routine intra-operative ultrasonography (IOUS) and resected specimens were sent for histopathology. Pathology findings were compared with those of MRI scans to determine the sensitivity of this imaging modality. Exclusions were patients undergoing hepatic resection more than 4 weeks after the MRI scan, those undergoing chemotherapy at the time of the scan, and those with conglomerate unilobar metastases. RESULTS Complete data were available for 84 patients. There was total agreement between MRI, IOUS and histology in 79 patients (101 metastases). MRI missed 5 metastases in 5 patients that were found on IOUS (or palpation of superficial lesions) and subsequently confirmed by histological examination. These measured 5 mm or less (4 patients) and 7 mm (one patient). The sensitivity of MRI in the detection of colorectal liver metastases was thus 94% for all lesions and 100% for lesions 1 cm or larger in diameter. CONCLUSIONS MRI of the liver is a non-invasive technique with an extremely high degree of sensitivity in the detection of colorectal liver metastases and should be considered as the ‘gold standard’ in the pre-operative imaging of these patients.
Potential Influence of Antisecretory Therapy on the Development of Candida-Associated Intraabdominal Infection
Authors: Cat Tram B , Charash William , Hebert James , Marden Brian T , Corbett Stephanie Mallow , Ahem John , Rebuck Jill A 
Published: January 2008

Background: Concerns surrounding the potential extra gut complication of gastric acid suppression are becoming increasingly realized. Objective: To determine whether chronic antisecretory treatment with a proton pump inhibitor (PPI) or histamine2-receptor antagonist (H2RA) is associated with the presence of Candida spp. in cases of complicated intraabdominal infection. Methods: We conducted a case-controlled study of adult surgical intensive care unit patients with complicated intraabdominal infection during a 5-year period. Exclusion criteria consisted at primary peritonitis, diagnosis of intraabdominal infection more than 72 hours before hospital admission, or a stay in the intensive care unit of less than 72 hours. Patients were categorized into either the antisecretory group (H2RA or PPI therapy prior to admission) or control group (no prior antisecretory therapy). Results: One hundred eighteen patients met inclusion criteria. Chronic antisecretory (n = 41) and control (n = 77) patients were similar except in median age (69.0 vs 59.0 y; p = 0.026) and preadmission antibiotic use (36.6% vs 15.6%; p = 0.010). The 2 groups had a similar proportion of patients with Candida (30.3% vs 32.1%; p = 0.857); the cultures included C, albicans, C. glabrata, and C. parapsilosis. Yeast was recovered more often in patients diagnosed with community-acquired intraabdominal infection and in patients who had used PPIs before hospital admission (p = 0.066). Additionally, Candida was cultured more often in antisecretory patients with a history ol prior abdominal surgery than in control patients (91.7% vs 62.5%; p = 0.066). Conclusions: No significant difference was found in the number of patients in the antisecretory and control groups from whom peritoneal Candida was recovered. However, patients with prior abdominal surgery and those in the community with chronic PPI use may be predisposed to Candida-associated intraabdominal infections.
Risk of Cerebrovascular Events Associated with Antidepressant Use in Patients with Depression: A Population-Based, Nested Case-Control Study
Authors: Chen Van , Guo Jeff J , Li Hong , Wulsin Lawson , Patel Nick C 
Published: January 2008

Background: Given the widespread use of antidepressants and the negative consequence of cerebrovascular events (CVEs), an evaluation of the risk of CVEs associated with antidepressants is warranted. Objective: To examine the association between the use of an antidepressant and risk of CVEs among patients diagnosed with depression. Methods: A case-control study was performed using a managed care medical claims database from 1998 through 2002. A total of 1086 cases with CVEs were identified and matched with 6515 controls by age, sex, and the year ol the index date of depression Case patients were categorized by stroke type: hemorrhagic stroke, ischemic stroke, and other CVEs. Diagnoses of depression, CVEs, and other medical comorbidities were identified based on International Classification of Diseases, Ninth Revision, codes. Patients were defined as current users (antidepressant ended ≤30 days before CVE). recent users (31–60 days before CVE), past users {61–90 days before CVE), and remote/nonusers (≥91 days before CVE or nonuse). Cox proportional hazards regression analysis was conducted to estimate the risk of CVEs associated with antidepressant use. Results: A 24% increased risk of a CVE was noted in patients with current exposure to selective serotonin-reuptake inhibitors (SSRIs; adjusted hazard ratio [HR) 1.24; 95% CI 1.07 to 1.44), 34% increased risk for current exposure to tricyclic antidepressants (HR 1.34; 95% CI 1.10 to 1.62), and 43% increased risk for current exposure toother antidepressants (HR 1.43; 95% CI 1.21 to 1.69). The risk of ischemic stroke in current SSRI users was significantly higher (HR 1.55; 95% CI 1.00 to 2.39) compared with remote/nonusers. Conclusions: Current users of antidepressants may be at increased risk of a CVE. Clinicians should consider the relationship of antidepressants with the occurrence of CVEs when determining the risk-benefit profile of pharmacologic treatment in patients with depression, particularly those with existing risk factors for a CVE.
Clinical Experience with Daptomycin for the Treatment of Patients with Documented Gram-Positive Septic Arthritis
Authors: Forrest Graeme N , Donovan Brian J , Lamp Kenneth C , Friedrich Lawrence V 
Published: January 2008

Background: Septic arthritis is considered a rheumatologic emergency that can lead lo joint destruction and tong-term impairment of joint function, Daptomycin is bactericidal in vitro against Staphylococcus aureus, the primary pathogen associated with septic arthritis. Objective: To describe the use of daptomycin in patients with septic arthritis, Methods: Data were collected as part of the Cubicin Outcomes Registry and Experience (CORE) program, a retrospective, observational, multicenter study, to describe the clinical use of daptomycin. Efficacy at the end of daptomycin therapy was determined by each center's investigator(s) as cure, improved, failure, or nonevaluable. Patients who had a diagnosis of septic arthritis, excluding concomitant osteomyelitis, as well as a positive culture by needle aspirate or deep tissue biopsy, were selected from the combined 2005 and 2006 CORE database. Results: Twenty-two patients were included in this analysis. S. aureus was the most common pathogen isolated, with the majority resistant lo methicillin. All patients received an antibiotic prior to daptomycin; in 7 patients, at least one of the prior antibiotics was continued with daptomycin. Almost two-thirds of patients received an antibiotic with daptomycin; rifampin was the most common. The median final dose and duration of daptomycin therapy were S mg/kg (range 3–6.3) and 22 days (range 3–52), respectively. Eighty-two percent of patients received daptomycin while admitted to a hospital; however, 68% received at least part ol their daptomycin therapy as an outpatient. The outcomes of cure or improved were reported in 41% and 50% of the patients, respectively. Two adverse events were reported; neither was considered to be related to daptomycin. Conclusions: Daptomycin appeared to be effective when used as part of a treatment regimen for septic arthritis. These results require verification via a prospective clinical trial.
Structural and Single-Channel Results Indicate That the Rates of Ligand Binding Domain Closing and Opening Directly Impact AMPA Receptor Gating
Authors: Zhang Wei , Cho Yoonsang , Lolis Elias , Howe James R. 
Published: January 2008

At most excitatory central synapses, glutamate is released from presynaptic terminals and binds to postsynaptic AMPA receptors, initiating a series of conformational changes that result in ion channel opening. Efficient transmission at these synapses requires that glutamate binding to AMPA receptors results in rapid and near-synchronous opening of postsynaptic receptor channels. In addition, if the information encoded in the frequency of action potential discharge is to be transmitted faithfully, glutamate must dissociate from the receptor quickly, enabling the synapse to discriminate presynaptic action potentials that are spaced closely in time.The current view is that the efficacy of agonists is directly related to the extent to which ligand binding results in closure of the binding domain. For glutamate to dissociate from the receptor, however, the binding domain must open. Previously, we showed that mutations in glutamate receptor subunit 2 that should destabilize the closed conformation not only sped deactivation but also altered the relative efficacy of glutamate and quisqualate. Here we present x-ray crystallographic and single-channel data that support the conclusions that binding domain closing necessarily precedes channel opening and that the kinetics of conformational changes at the level of the binding domain importantly influence ion channel gating. Our findings suggest that the stability of the closed-cleft conformation has been tuned during evolution so that glutamate dissociates from the receptor as rapidly as possible but remains an efficacious agonist.
The characterisation of microstructural changes in rapidly solidified Al–Fe alloys through measurement of their electrical resistance
Authors: Bizjak Milan , Kosec Ladislav , Kneissl Albert C. , Kosec Borut 
Published: January 2008

Abstract
Microstructural changes of rapidly solidified Al alloy ribbons of various thicknesses and containing different concentrations of iron were analysed. The kinetics and sequence of microstructural changes occurring at a constant heating rate were analysed through the measurement of electrical resistance. This method allowed detection of the transition between metastable and stable phases of rapidly solidified Al – Fe alloy ribbons with various concentrations of iron and various thicknesses. After determining the temperature regions throughout the heating cycle, the quenched microstructure was analysed at transition points using both optical and transmission electron microscopy. Precipitation is the most common reaction for these types of alloys, and the most important alloy formed is Al13Fe4.
Microstructure, texture and mechanical properties of the magnesium alloy AZ31 processed by ECAP
Authors: Estrin Y. , Yi S. B. , Brokmeier H.-G. , Zúberová Z. , Yoon S. C. , Kim H. S. , Hellmig R. J. 
Published: January 2008

Abstract
To investigate the influence of equal channel angular pressing on the microstructure and texture of the magnesium alloy AZ31, electron backscattering diffraction and well as neutron diffraction experiments were carried out. Through these experiments it was possible to trace the microstructure and texture evolution with strain accumulated with the increasing number of equal channel angular pressing passes. It was further demonstrated by subsequent compression tests that the microstructural changes produced by equal channel angular pressing have a beneficial effect on both the compressive strength and ductility of AZ31.
Reproductive traits following a parent–child separation trauma during childhood: A natural experiment during World War II
Authors: Pesonen Anu‐Katriina , Räikkönen Katri , Heinonen Kati , Kajantie Eero , Forsén Tom , Eriksson Johan G. 
Published: February 2008

AbstractGiven the ethical limitations of exposing children to experimentally manipulated adverse experiences, evidence of the effects of childhood traumas on subsequent life history are based mostly on women's retrospective reports and animal studies. Only a few prospective studies have assessed the life‐long consequences of childhood trauma. We asked whether a traumatic separation from both parents during childhood is associated with reproductive and marital traits later in life, measured by age of onset of menarche, timing of menopause, period of fertile years, age at first childbirth, birth spacing, number of children, and history of divorce. We studied members of the 1934–1944 Helsinki Birth Cohort, including 396 former war evacuees from varying socioeconomic backgrounds, who were sent unaccompanied by their parents to temporary foster families in Sweden and Denmark, and 503 participants who had no separation experiences. Data on separation experiences, number of children, and divorces experienced came from national registers, and the remaining data from a survey among the participants aged 61.6 years (SD = 2.9). Former evacuees had earlier menarche, earlier first childbirth (men), more children by late adulthood (women), and shorter interbirth intervals (men), than the non‐separated. A traumatic experience in childhood is associated with significant alterations in reproductive and marital traits, which characterize both women and men. The implications are relevant to the 9.2 million child refugees living throughout the world today. Am. J. Hum. Biol., 2008. © 2008 Wiley‐Liss, Inc.
Development and validation of a sensitive LC‐MS/MS method with electrospray ionization for quantitation of doxofylline in human serum: application to a clinical pharmacokinetic study
Authors: Sreenivas Nimmagadda , Narasu M. Lakshmi , Shankar B. Prabha , Mullangi Ramesh 
Published: February 2008

AbstractA highly sensitive and specific LC‐MS/MS method has been developed and validated for the estimation of doxofylline (DFL) with 300 µL human serum using imipramine as the internal standard (IS). The API‐3000 LC‐MS/MS was operated under multiple reaction‐monitoring mode using the electrospray ionization technique. The assay procedure involved direct precipitation of DFL and IS from human serum with acetonitrile. The resolution of peaks was achieved with formic acid (pH 2.5):acetonitrile (10:90, v/v) on an Amazon C18 column. The total chromatographic run time was 3.0 min and the elution of DFL and IS occurred at approximately 1.46 and 2.15 min, respectively. The MS/MS ion transitions monitored were 267.5 → 181.1 for DFL and 281.1 → 86.2 for IS. The method was proved to be accurate and precise at linearity range of 1.00–5000 ng/mL with a correlation coefficient (r) of ≥0.999. The method was rugged with 1.00 ng/mL as lower limit of quantitation. The intra‐ and inter‐day precision and accuracy values were found to be within the assay variability limits as per the FDA guidelines. The developed assay method was applied to a pharmacokinetic study in human volunteers following oral administration of DFL tablet. Copyright © 2008 John Wiley & Sons, Ltd.
ChemInform Abstract: Rb3Y2(BO3)3 with a Noncentrosymmetric Structure.
Authors: Gao J. H. , Li R. K. 
Published: February 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Iranite, CuPb10(CrO4)6(SiO4)2 (OH)2, Isomorphous with Hemihedrite.
Authors: Yang Hexiong , Sano Jennifer L. , Eichler Carla , Downs Robert T. , Costin Gelu 
Published: February 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Hg0.04Zn3.96Sb3: Synthesis, Crystal Structure, Phase Transition, and Thermoelectric Properties.
Authors: Pedersen B. L. , Birkedal H. , Nishibori E. , Bentien A. , Sakata M. , Nygren M. , Frederiksen P. T. , Iversen B. B. 
Published: February 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Deposition of Lanthanum Zirconium Oxide High‐k Films by Liquid Injection ALD and MOCVD.
Authors: Gaskell Jeffrey M. , Jones Anthony C. , Chalker Paul R. , Werner Matthew , Aspinall Helen C. , Taylor Stephen , Taechakumput Pouvanart , Heys Peter N. 
Published: February 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Progress in Rechargeable Magnesium Battery Technology.
Authors: Aurbach Doron , Suresh Gurukar Shivappa , Levi Elena , Mitelman Ariel , Mizrahi Oren , Chusid Orit , Brunelli Michela 
Published: February 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Microwave Synthesis of Hydrotalcite by Urea Hydrolysis.
Authors: Yang Zhiqiang , Choi Kwang‐Min , Jiang Nanzhe , Park Sang‐Eon 
Published: February 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Asymmetric Sulfimidation with cis‐β Ru(salalen)(CO)2 Complexes as Catalyst.
Authors: Fujita Hidekazu , Uchida Tatsuya , Irie Ryo , Katsuki Tsutomu 
Published: February 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Asymmetric Aldol Additions with a Titanium Enolate of N‐Thioglycolyl Oxazolidinethione.
Authors: Ortiz Aurelio , Sabala Rocio , Sansinenea Estibaliz , Bernes Sylvain 
Published: February 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: New C2‐Symmetric Optically Active Salen Ligands and Their Cobalt(II) Complexes. Hydridoborate Reduction of Prochiral C=O and C=C Bonds.
Authors: Nindakova L. O. , Lebed' F. M. , Zamazei A. Yu. , Shainyan B. A. 
Published: February 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Regioselective and Stereoselective Methoxy‐Bromination of Olefins Using (Diacetoxyiodo)benzene and Lithium Bromide.
Authors: Karade Nandkishor N. , Gampawar Sumit V. , Tiwari Girdharilal B. 
Published: February 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Regiochemistry of Zirconacycle Elaboration.
Authors: Thomas Emma , Dixon Sally , Whitby Richard J. 
Published: February 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.