bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel phenotypic marker for ATM‐deficient 129S6/SvEvTac‐ATMtm1Awb/J mice
Authors: Hibma Jody C. , Neufeld Daniel A. , Halaby Marie‐Jo , Yang Da‐Qing 
Published: February 2007

AbstractAtaxia‐telangiectasia (A‐T) is a human autosomal recessive disorder characterized by neuronal degeneration as well as many other physiological and somatic defects. ATM (A‐T, mutated), the gene mutated in A‐T, encodes a 370 kDa protein kinase. ATM knockout mouse models (ATM−/−) show growth retardation, infertility, neurological dysfunction, defects in T‐lymphocytes, and extreme sensitivity to ionizing radiation. We have recently established multiple ATM+/− breeding pairs and discovered that all ATM−/− offspring exhibit a nonpigmented section of tail, usually at or near the tip. To our knowledge, this is the first time that a phenotype of nonpigmented tail has been reported in ATM−/− knockout mice. We believe that the sections of nonpigmented tail of 129S6/SvEvTac‐ATMtm1Awb/J mice provide a novel phenotypic marker for research using this ATM knockout mouse model. Results from histochemistry and immunoblotting analysis further demonstrate that while melanocyte precursors or melanoblasts are present in the nonpigmented tail tissue of ATM−/− mice, they fail to differentiate fully into mature melanocytes. The potential connection between this phenotype and other clinical symptoms caused by ATM deficiency, such as progressive neuronal degeneration, is discussed in this article. Anat Rec, 2007. © 2007 Wiley‐Liss, Inc.
The problem of therapeutic evaluation in Rheumatoid Arthritis
Authors: Wallace Stanley L. , Ragan Charles 
Published: February 2007

AbstractThe difficulties encountered in the evaluation of therapy for rheumatoid arthritis are reviewed. The authors stress the necessity for controlled studies, blind comparisons of untested agents, appropriate methods for measurement of therapeutic response and statistical evaluation of results.Le difficultates incontrate in le evalutation de therapias pro arthritis rheumatoide es delineate. Le autores sublinea le necessitate de studios a controlo, de comparationes “occultate” de nove agentes, de appropriate methodos pro le mesuration del responsa therapeutic, e del evalutation statistic del resultatos.
Salicylates and adrenocortical function in man
Authors: Peterson Ralph E. , Black Roger L. , Bunim Joseph T. 
Published: February 2007

AbstractThe administration of moderate doses of salicylate for a few days to normal subjects and patients with rheumatoid arthritis produced no alteration in adrenal function or hydrocortisone metabolism. Subjects given large doses of salicylate for 30 or more days showed a decreased rate of metabolism and synthesis of hydrocortisone.Five normal controls, and four patients with active rheumatoid arthritis served as the subjects of this study.Le administration de moderate doses de salicylatos, durante alicun dies, a subjectos normal e a patientes con arthritis rheumatoide produceva nulle alteration in le function adrenal o in le metabolismo de hydrocortisona. Individuos recipiente grande doses de salicylatos, durante periodos de 30 dies o plus, monstrava un reduction del metabolismo e del synthese de hydrocortisona.Quatro patientes con active arthritis rheumatoide e cinque normal individuos de controlo esseva le subjectos de iste studio.
Peripheral neuritis associated with rheumatoid arthritis
Authors: Irby Robert , Adams Raymond A. , Toone Elam C. 
Published: February 2007

AbstractInvolvement of peripheral nerves has, thus far, received too little attention as a systemic manifestation of rheumatoid disease. This article describes peripheral neuropathy in six patients with rheumatoid arthritis, all of whom were receiving or had received adrenal steroid therapy. Histologic studies revealed diffuse angiitis and suggested that vascular involvement of the nerve trunk contributed to the pathogenesis of the neuropathy.Le affection de nervos peripheric como manifestation de morbo rheumatoide non ha, usque nunc, habite le attention que illo merita. Iste articulo describe neuropathia peripheric in sex patientes con arthritis rheumatoide qui omnes recipeva o habeva recipite therapia adreno‐steroide. Studios histologic rvelava diffuse angiitis e suggereva que un affection vascular del trunco nervose contribueva al pathogenese del neuropathia.
The latex fixation test using whole serum and an euglobulin fraction in various arthritic disorders
Authors: Olsen C. Robert , Rantz Lowell A. 
Published: February 2007

AbstractThe euglobulin fraction of sera from patients with rheumatoid arthritis gave a higher percentage of positive latex fixation tests than whole sera. The results of such tests correlated with the number of diagnostic criteria for rheumatoid arthritis present.Le fraction euglobulinic de seros ab patientes con arthritis rheumatoide rendeva un plus alte procentage de tests positive de fixation a latex que seros integre. Le resultatos de tal tests se correlationava con le numero del incontrate criterios diagnostic pro arthritis rheumatoide.
Leukocyte disc method for L.E. cell test in serum and serum fractions
Authors: Fallet Georges H. , Ziff Morris 
Published: February 2007

AbstractA simplified technic for the demonstration of the L.E. factor is described in which living granylocyte discs are deposited on glass slides and incubated with serum or serum fractions. The method was found satisfactory in 458 of 478 tests and produced results similar to other technics.Es describite un simplificate technica pro le demonstration del factor lupo‐erythematose (L.E.). In illo, discos de vive granulocytos es deponite super plattas de vitro e incubate con sero o fractiones seral. Le methodo se provava satisfactory in 458 ex 478 tests e produceva resultatos simile a altere technicas.
Fixation of S35 in the skin of patients with progressive systemic sclerosis
Authors: Denko Charles W. , Stoughton Richard B. 
Published: February 2007

AbstractA preliminary study of the fate of radioactive sulfur (Na2S35O4) given intravenously to patients with progressive systemic sclerosis has revealed an appreciably greater radioactivity in the involved skin. The evidence presented suggests an abnormal rate of uptake of sulfur in the sclerotic skin even in the absence of progression.Un studio preliminari del destino de sulfure radioactive (Na2S35O4), administrate intravenosemente a patientes con progressive sclerosis systemic ha revelate un appreciabilemente plus forte radio‐activitate in le pelle afficite. Le observationes reportate suggere que pelle sclerotic, mesmo in le absentia de progression del processo, accepta un proportion anormal del sulfure.
Relation of “agammaglobulinemia” sera to rheumatoid agglutination reactions
Authors: Vaughan John H. , Good Robert A. 
Published: February 2007

AbstractIn an effort to elucidate the nature of the polyarthritis and other systemic Lesions occurring during the course of hypogammaglobulinemia, sera from patients with hypogammaglobulinemia were tested by serveral procedures for demonstration of the rheumatoid factor or its inhibitor. Neither agglutinator of inhibitor was present in the twelve patients studied, six of whom had arthritis. A possible relationship between the arthritis of agammaglobulinemia and rheumatoid arthritis culd not be confirmed. However, for reasons described, such a relationship could not be excluded.Con le objectivo de elucidar le natura del polyarthritis e del altere lesiones systemic que occurre in le curso de hypogammaglobulinemia, seros ab patientes con hypogammaglobulinemia esseva testate per varie technicas pro le presentia del factor rheumatoide o de su inhibitor. In le dece‐duo patientes studiate, incluse sex con arthritis, ni agglutinator ni inhibitor esseva presente. Le existentia possibile de un relation inter le arthritis de agammaglobulinemia e arthritis rheumatoide non poteva esser confirmate. Tamen, pro rationes describite, excluder le existentia de ille relation esseva etiam impossibile.
Peptic ulcer in rheumatoid patients on corticosteroid therapy. A clinical, experimental and radiologic study
Authors: Kammerer William H. , Freiberger Robert H. , Rivelis Abraham L. 
Published: February 2007

AbstractAn extensive study of the relationship of peptic ulcer to adrenal steroid therapy has led to the conclusion that certain corticosteroids are responsible for gastric ulceration, probably as a result of direct effects on the mucosa.Peptic ulcer was observed radiographically in 31 per cent of patients with rheumatoid arthritis receiving adrenal steroids but in only 9 per cent of patients not treated and 5 per cent of nonrheumatoid controls. Hydrochloric acid and pepsin secretion were not influenced significantly by the administration of corticosteroids.Un extense studio del relation inter ulcere peptic e therapia adreno‐steroide ha resultate in le conclusion que certe corticosteroides es responsabile pro ulceration gastric, probabilemente in consequentia de effectos directe super le mucosa.Ulcere peptic esseva observate radio‐graphicamente in 31 pro cento de patientes con arthritis rheumatoide qui recipeva steroides adrenal sed solmente in 9 pro cento de tal patientes qui non recipeva steroides adrenal e in 5 pro cento de non‐rheumatoide subjectos de controlo. Le secretion de acido hydrochloric e de pepsina non esseva influentiate a grados significative per le administration de corticosteroides.
The latex fixation test for rheumatoid arthritis using patients' own gamma globulin
Authors: Singer Jacques M. , Plotz Charles M. 
Published: February 2007

AbstractThe originators of the “latex fixation test” for rheumatoid arthritis have observed that modifications of their original procedure can increase the number of positive results to 90 per cent of rheumatoid patients without increasing the frequency of false positive reactions. An ammonium sulfate fraction of the patient's own serum serves as the “reactant,” eliminating the necessity of using commercially prepared gamma globulin.Le originators del “test de fixation a latex” pro arthritis rheumatoide ha observate que modificationes de lor technica original pote augmentar le numero del resultatos positive a 90 pro cento del patientes rheumatoide, sin augmentar le frequentia de reactiones falsemente positive. Un fraction a sulfato de ammonium obtenite ab le sero del patiente mesme servi como “reactante,” eliminante le requirimento de globulina gamma de preparation commercial.
Sialic acid in normal and arthritic human synovial fluids
Authors: Pigman Ward , Hawkins William L. , Blair Mary Grace , Holley Howard L. 
Published: February 2007

AbstractThe authors report careful and significant studies of the synovial fluid concentrations of sialic acid, a term which is applied to a group of related compounds first isolated from saliva. The nature of such compounds is reviewed.Since available methods for determining sialic acid are not specific, two colorimetric procedures were applied. A critical discussion of methodology is presented.Increased concentrations of sialic acid were observed in both the synovial fluids and sera of rheumatoid patients.Le autores reporta meticulose e significative studios in re le concentration—in le fluido synovial—del si‐appellate acido sialic. Iste termino es applicate a un gruppo de inter‐relationate compositos primo isolate ab specimens de saliva. Le natura de tal compositos es passate in revista.Viste que le nunc disponibile methodos pro determinar acido sialic non es specific, duo technicas colorimetric esseva applicate. Es presentate un discussion critic del methodologia.Augmentate concentrationes de acido sialic esseva observate in le fluidos synovial e in le seros de patientes rheumatoide.
On renal involvement in systemic lupus erythematosus and other so‐called collagen diseases
Authors: Pollak Victor E. , Pirani Conrad L. , Muehrcke Robert C. , Pulos Peter C. , Kark Robert M. , Steck Irving E. 
Published: February 2007

AbstractMicroscopic studies of renal lesions in patients with systemic lupus erythematosus, rheumatoid arthritis, thrombotic thrombocytopenic purpura and scleroderma have provided additional information concerning involvement of the kidney in these connective tissue diseases. A detailed description of the nephritis of systemic lupus erythematosiis has been made possible by a technic for serial renal biopsy.Studios microscopic de lesiones renal in patientes con systemic lupus erythematose, arthritis rheumatoide, purpura thrombocytopenic thrombotic, e scleroderma ha producite informationes additional in re le affection del ren in iste morbos del histos conjunctive. Un detaliate description del nephritis de systemic lupus erythematose ha devenite possibile gratias a un technica de biopsias renal in serie.
The effects of serum complement and its components on the rheumatoid latex fixation test
Authors: Brine Katherine L. , Wedgwood Ralph J. , Clark William S. 
Published: February 2007

AbstractIn the application of the rheumatoid latex fixation test, agglutination may fail to occur in the presence of high concentrations of positive sera in a pattern resembling the prozone of some antigen‐antibody reactions. The serum factors responsible for the prozone phenomenon in the rheumatoid latex fixation test have the properties of the second and fourth components of human complement.In le application del test rheumatoide de fixation a latex, non‐agglutination pote occurrer in le presentia de alte concentrationes de seros positive. Le configuration resimila alora le prozona de certe reactiones de antigeno e anti‐corpore. Le factores seral que es responsabile pro le phenomeno prozonal in le test rheumatoide de fixation a latex ha le proprietates del secunde e del quarte componente de complemento human.
The genetically determined serum haptoglobins in rheumatoid arthritis
Authors: Allison A. C. , Blumberg B. S. 
Published: February 2007

AbstractSerum haptoglobin concentrations were found elevated in patients with rheumatoid arthritis. The frequencies of haptoglobin types which are determined genetically were the same in rheumatoid patients as in controls. The nature of haptoglobins and methods of determination are discussed.Esseva constatate que le concentrationes del haptoglobinas seral esseva elevate in patientes con arthritis rheumatoide. Le frequentia del typos de haptoglobina a determination genetic esseva le rnesme in patientes rheumatoide e subjectos de controlo. Le natura del haptoglobinas e methodos pro lor determination es discutite.
Observations on the treatment of rheumatic fever with salicylate, ACTH and cortisone. II. Combined salicylate and corticoid therapy and attempts at rebound suppression
Authors: Fischel Edward E. , Frank Charles W. , Boltax Adolph J. , Arcasoy Mufit 
Published: February 2007

AbstractThe administration of adrenal hormones combined with salicylate to 41 patients having acute rheumatic fever resulted in prompt and sustained remissions of rheumatic activity. Following cessation of hormone therapy, suppression of the disease was achieved by the continuous administration of salicylate. Although relative effectiveness of this method of treatment could not be firmly established, the observed results suggest that a combination of antirheumatic agents is beneficial.
Two‐year comparative study of serial hemagglutination tests done on groups of rheumatoid arthritis patients
Authors: De Forest Gideon K. , Mucci Mary B. , Boisvert Paul L. 
Published: February 2007

AbstractAdditional evidence is presented which indicates a relationship between the disease activity of rheumatoid arthritis and a positive hemagglutination test. Grade I remissions in cases of “definite” rheumatoid arthritis are usually accompanied by negative tests which revert to positive with exacerbation of the disease. Progressive disease in patients with “definite” rheumatoid arthritis is associated with sustained positive tests, while patients classified as having “possible” rheumatoid arthritis have negative tests.
Studies concerning the relationship of phenylbutazone to pituitary‐adrenal cortical function and metabolism of 17‐hydroxycorticosteroids
Authors: Good Thomas A. , Kelley Vincent C. 
Published: February 2007

AbstractMeasurements of the effects of phenylbutazone on the adrenal cortex and on corticosteroid metabolism of experimental animals have indicated that therapeutic activity of this drug is probably not related to changes in adrenocortical function. Additional data concerning the influence of phenylbutazone on renal excretory activity were obtained which with previously reported observations suggested that the physiologic effects on the kidney are a result of changes in the binding capacity of body protein systems.
Results of a clinical trial of g‐28315, a sulfoxide analog of phenylbutazone, as a uricosuric agent in gouty subjects
Authors: Yü T. F. , Burns J. J. , Gutman Alexander B. 
Published: February 2007

AbstractTwo analogs of phenylbutazone, labelled G‐25671 and G‐28315, have been shown to have potent uricosuric effects. This report concerns the therapeutic properties in 44 patients of G‐28315, which is a sulfoxide metabolite of G‐25671. Although the effects of this agent compared favorably with probenecid, the periods of administration were not sufficiently long to exclude toxicity.
The incidence of leukemia and related diseases in patients with rheumatoid (ankylosing) spondylitis treated with X‐ray therapy
Authors: Silberberg Donald H. , Frohman Lawrence A. , Duff Ivan F. 
Published: February 2007

AbstractIn a series of 496 rheumatoid spondylitis patients treated with x‐ray, the authors have reported an incidence of leukemia over 17 times greater than expected in a comparable population. No conclusion can be drawn with respect to the exact nature of dose‐response relationship in leukemogenesis. Four of the reported leukemias arose from myeloid reticular elements of the bone marrow; the fifth case is of undetermined origin. Since the chief use of x‐ray therapy under these circumstances is as an analgesic, it would seem unwise to compound the risk of developing leukemia in these patients by its continued use unless all other forms of symptomatic treatment have failed and the patient and the physician mutually accept the possibility of this increased hazard.
The physiologic effects of dexamethasone
Authors: West Kelly M. , Johnson Philip C. , Kyriakopoulos Adrian A. , Bahr W. Julian , Bloedow Carmen E. 
Published: February 2007

AbstractThe hyperglycemic, eosinopenic and adrenal suppressive potencies of dexamethasone in man were all found to be similar to the previously reported anti‐inflammatory potency of this drug (about 5 to 8 times those of prednisolone and 25 to 30 times those of hydrocortisone). Dexamethasone (1.5 mg. three times daily) produced a slight antidiuresis of sodium, chloride and water of equivocal significance. A marked but transitory potassium diuresis occurred. Excretion of urinary magnesium was unaffected.
Examination of the latex fixation test using sulfated mucopolysaccharides
Authors: Heimer Ralph , Freyberg Richard H. 
Published: February 2007

AbstractThe sulfated mucopolysaccharides heparin and chondroitin sulfate are immunologically inactive toward highly purified rheumatoid factors or any other components of the serum of individuals with rheumatoid arthritis. Positive latex fixation tests of selected serum samples using heparin in place of human gamma globulin are due to the simultaneous presence of endogenous gamma globulin. Nearly similar results may he obtained with latex tests using no coating agent whatever. Addition of heparin to latex suspensions imparts stability to the colloidal dispersion and remedies prozone phenomena encountered in such titrations.
The stiff‐man syndrome: Report of a case
Authors: Stuart Fletcher S. , Henry Margaret , Holley Howard L. 
Published: February 2007

AbstractAn additional case of the stiff‐man syndrome manifested by extremely painful, fluctuating muscular spasm and rigidity is reported. Eighteen cases previously reported in the literature are reviewed, and the accumulated indications for a metabolic defect and/or myopathy are presented.
Cardiac lesions in rheumatoid arthritis
Authors: Goehrs Homer R. , Baggenstoss Archie H. , Slocumb Charles H. 
Published: February 2007

AbstractPost‐mortem cardiac examinations of 36 patients who had rheumatoid arthritis revealed a high incidence of lesions suggesting previous attacks of rheumatic fever. A variety of inflammatory changes were observed supporting previous reports of similar studies.
Observations on the measurement of joint stiffness
Authors: Wright Verna , Johns Richard J. 
Published: February 2007

AbstractJoint stiffness is a major manifestation of joint disease. Nevertheless, an extensive review of the literature reveals that little has been done to characterize joint stiffness quantitatively or qualitatively. A method is described whereby joint stiffness can be measured in precise physical terms. The major components of joint stiffness in normal and arthritic subjects are elasticity and plasticity. Viscous stiffness is small, and friction is negligible even in badly damaged joints.
The relationship of human genital pleuropneumonia‐like organisms to arthritis complicating urethritis
Authors: Ford Denys K. 
Published: February 2007

AbstractA tissue culture method, employing human amnion cells was applied to the primary isolation of PPLO from patients with venereally acquired urethritis and complicating arthritis. Fifteen synovial exudates from 12 patients with arthritis failed to reveal PPLO by this method. In addition, 240 patients attending a venereal disease clinic were investigated and 75 PPLO strains isolated, but no evidence was obtainable that PPLO were etiologically related to nongonococcal urethritis or Reiter's syndrome.
Periarthritis produced in rats with Freund's adjuvants
Authors: Silverstein Emanuel , Sokoloff Leon 
Published: February 2007

AbstractEvidence is presented that the inflammatory swelling of the paws produced in rats by injection of Freund's adjuvants does not represent an arthritis; and that such swellings like the visceral granulomata observed in these animals, arise by migration of adjuvant materials from the depot site.
The mechanism of particulate carrier reactions with rheumatoid sera. II. Sensitizing capacity of various human gamma globulins for latex particles
Authors: Singer Jacques M. , Altmann Gideon , Goldenberg Arnold , Plotz Charles M. 
Published: February 2007

AbstractLatex particles can be sensitized by 7S gamma globulin as well as by aggregated gamma globulin. The excess of gamma globulin not on the particle surface may act as an inhibitor of agglutination if it is in the aggregated state. Studies are presented to demonstrate the sensitizing capacity of various human gamma globulin preparations for latex particles.
Vasculitis, Mast Cells and the Collagen Diseases
Authors: Smyth Charley J. , Gum Oren B. 
Published: February 2007

AbstractPurpura and necrotizing vasculitis complicate high dose adrenocortical therapy in rheumatoid arthritis. Pathological changes in five cases are summarized. Tissue mast cells are concentrated around blood vessels and store heparin, histamine, hyaluronic acid and in some species, serotonin. These pleuri‐potential cells upon „trauma”︁ yield these potent biological substances which may act as prime movers in the inflammatory reaction. Association of these cells with adrenocortical steroids, fibrogenesis and anaphylaxis is further evidence that they play a role in the panangiitic reaction of hypercortisonism.
Isolation of rheumatoid factors
Authors: Heimer Ralph , Schwartz Edith R. 
Published: February 2007

AbstractA method for the separation of rheumatoid factors into two serologically distinct macroglobulins is described. Macroglobulins, reacting with cells coated with human as well as with rabbit gamma globulin, were found to be mainly 19.4S, but occasionally such preparations contained minor constituents sedimenting at 22s as well as 27s. Macroglobulins which reacted with cells coated with human gamma globulin, but which were inactive when rabbit gamma globulin was used, were mainly 19.5S. Some sera, however, contained substances serologically similar in behavior but sedimenting at 17.5S, 22.0S, and 27s.