bluuebunny/crossref_metadata_2025_split huggingface dataset:
Selected benefits of thoracotomy and chemotherapy for sarcoma metastatic to the lung
Authors: Mentzer Steven J. , Antman Karen H. , Attinger Christopher , Shemin Richard , Corson Joseph M. , Sugarbaker David J. 
Published: February 2007

AbstractTo determine the benefit of aggressive surgical therapy, we studied 77 consecutive patients presenting to our sarcoma registry with pulmonary metastases. Detailed follow‐up was available on all patients; the median follow‐up of the 13 long‐term survivors was 72 months from the date of diagnosis of the primary tumor. Survival of these 77 patients with metastatic disease was independent of the size, location, and histology of the primary tumor. Once metastases developed, survival of patients with pulmonary metastases was not influenced by the extent of surgical resection of the primary tumor or by the use of radiation therapy. Pulmonary metastases were initially treated with thoracotomy and metastasectomy in 34 patients. The median survival after thoracotomy was 26 months. Seven patients were alive more than 4 years after their diagnosis. Pulmonary metastases were treated with chemotherapy alone in 43 patients. Although the survival was shorter (median survival 14 months) in patients treated with chemotherapy, an objective response to chemotherapy was obtained in 13 (30%) patients. Four of these patients were alive 4 years after their diagnosis. These data demonstrate that both thoracotomy and chemotherapy are associated with long‐term survival of patients with sarcoma metastatic to the lung. © 1993 Wiley‐Liss, Inc.
Prognostic factors for well‐differentiated squamous cell carcinoma in the oral cavity with emphasis on immunohistochemical evaluation
Authors: Horiuchi Keisuke , Mishima Kenji , Ohsawa Masahiko , Sugimura Masahito , Aozasa Katsuyuki 
Published: February 2007

AbstractHistological and immunohistological prognostic factors for well‐differentiated oral squamous cell carcinoma (SCC) were examined in 31 patients. They included 18 males and 13 females aged 42–84 (median 63) years. The tumors were located in the tongue in 13 cases, gingiva in 7, floor of the mouth in 5, cheek mucosa in 4, and palate in 2. Advanced disease (stages III and IV) was found in 92% of patients; 22 were treated by radical surgery and nine by excisional or incisional biopsy, followed by adjuvant chemotherapy and external radiation. The 5‐year survival rate in patients with stages III and IV disease was 58% and 33%, respectively. Histologic factors evaluated were tumor cell mitotic counts, degree of lymphocyte and eosinophil infiltration around the tumor, mast cell counts, HLA‐DR expression on tumor cells, or surrounding lymphocytes. Multivariate analysis revealed that degree of eosinophilic infiltration and expression of HLA‐DR antigen on the tumor cells were significant factors for prognosis (P <0.05); i.e., heavy eosinophilic infiltration and expression of HLA‐DR antigen on tumor cells were signs of an unfavorable prognosis. The interpretation of the present findings are discussed with a review of the literature. © 1993 Wiley‐Liss, Inc.
Prognostic significance of flow cytometric analysis of DNA content in colorectal cancer: A prospective study
Authors: Tomoda Hirotsugu , Kakeji Yoshihiro , Furusawa Motonosuke 
Published: February 2007

AbstractWe prospectively analyzed the tumor DNA content by flow cytometry in 100 patients who underwent a curative resection for colorectal cancer between August 1989 and May 1992 in order to evaluate the prognostic significance of DNA ploidy and the DNA index (DI). Patients with aneuploid tumors were found to have a significantly shorter disease‐free survival than those with diploid tumors (P =0.014). In addition, patients who had tumors with a DI greater than 1.6 had a significantly shorter disease‐free survival than those who had tumors with a DI of less than 1.6 (P= 0.0001). After stratification by stage, this association was only seen in Dukes' stage C disease (P= 0.0065). Cox's regression analysis demonstrated that the DI (below or above 1.6) rather than DNA ploidy was an important independent predictor of disease‐free survival. These results suggest that the DI rather than DNA ploidy provides us with important prognostic information in patients undergoing curative surgery for colorectal cancer. © 1993 Wiley‐Liss, Inc.
Testicular seminoma stage I: Treatment results and long‐term follow‐up (1968–1988)
Authors: Stein Moshe Efraim , Kessel Ivan , Luberant Norman , Kuten Avraham 
Published: February 2007

AbstractSixty‐nine patients with stage I testicular seminoma were referred to the Northern Israel Oncology Center between 1968 and 1987. Sixty‐four patients were irradiated postoperatively and five patients had surveillance alone. Complete follow‐up was available for all patients, with a median follow‐up of 86 months (range 9–239 months). The last follow‐up was in December 1988. Actuarial survival was 94% to 5, 10, 15, and 20 years. Six patients relapsed following completion of irradiation. All the recurrences occurred outside the radiation field. Three of the relapsed patients could be salvaged with cisplatinum‐based chemotherapy and are alive at 4, 7, and 10 years following second‐line treatment. Acute or chronic side effects were mild and manageable. Seven patients developed second primary cancers, two within and six outside the radiation field. While surveillance policy alone in stage I testicular seminoma may be successful in terms of patient outcome, it requires prolonged observation, good compliance of patients, and intensive use of resources. Thus, until proved otherwise, infradiaphragmatic radiotherapy should further remain the optimal routine treatment in seminoma patients with stage I disease. © 1993 Wiley‐Liss, Inc.
Prognosis for patients with carcinoma in the middle third of the stomach
Authors: Anai Hideaki , Maehara Yoshihiko , Oshiro Tatsuo , Baba Hideo , Orita Hiroyuki , Okuyama Toshiro , Sugimachi Keizo 
Published: February 2007

AbstractIn 268 of the 1,115 patients (24.0%) with gastric cancer who underwent a curative resection in our clinics, the tumor was located in the middle third of the stomach. The clinicopathological features and prognosis of these patients were divided into two groups, according to site of the tumor: anterior wall (n = 58) vs. other sites (n = 210). Clinicopathological factors did not differ between the two groups. The survival time for patients with a tumor in the anterior group was shorter than that for patients with a tumor in other areas (P <0.05). The five‐year survival rate was 79.3% for patients with an anterior tumor and 91.9% for those with a tumor at a different site. A multivariate analysis indicated lymph node metastasis, serosal invasion, and anterior wall location to be independent prognostic factors indicative of a poor prognosis when the tumor was located in the middle third of the stomach. For such patients, close follow‐up is needed to detect possible recurrences. © 1993 Wiley‐Liss, Inc.
DNA ploidy as a major prognostic factor in resectable ampulla of vater cancers
Authors: Shyr Yi‐Ming , Su Cheng‐Hsi , Wu Li‐Hwa , Li Anna Fen‐Yau , Chiu Jen‐Hwey , Lui Wing‐Yiu 
Published: February 2007

AbstractThe archival paraffin‐embedded specimens from 63 ampulla of Vater cancers after pancreaticoduodenectomy between 1965 and 1991 were analyzed by flow cytometry. Of the 63 cancers, 31 (49.2%) were diploid DNA cancers and 32 (50.8%) were aneuploid. Patients with diploid DNA cancer had a median survival time of 159.0 months, and patients with aneuploid DNA cancer had 24.0 months. This difference is statistically significant (P =0.0257). The aneuploid group did have a poorer prognosis than the diploid group. The multivariate analysis demonstrated that DNA ploidy was an independent and very important prognostic factor, even stronger than the stage and lymph node status. There was a tendency toward higher values of S‐phase fraction, proliferative index, and total aneuploid DNA fraction in the shorter survival groups, but they were of no statistical significance. These data suggest that DNA ploidy appears to be the most important and the only pre‐operative predictor of prognosis in resectable ampulla of Vater cancers since endoscopic biopsy is feasible. © 1993 Wiley‐Liss, Inc.
Multiple primary gynecologic neoplasms in a young HIV‐positive patient
Authors: Rose Peter G. , Fraire Armando E. 
Published: February 2007

AbstractImmune suppression from human immunodeficiency virus (HIV) infection is frequently associated with the development of certain neoplasms, including Kaposi's sarcoma and non‐Hodgkin's lymphoma. A young patient with a 5‐year history of HIV infection was found simultaneously to have invasive carcinoma of the breast, microinvasive carcinoma of the cervix, and intraepithelial neoplasia of the vulva. In view of the early nature of these neoplasms, conservative therapy was utilized; lumpectomy and adjuvant radiation therapy, conservative hysterectomy, and local therapy for the breast carcinoma, cervical carcinoma and vulvar intraepithelial neoplasia, respectively. Epithelial malignancies appear to be more common in the HIV‐positive population than previously appreciated. To our knowledge this is the first report of multiple primary gynecologic neoplasms in association with HIV infection. © 1993 Wiley‐Liss, Inc.
Extent of hepatic resection as a prognostic factor for small, solitary hepatocellular carcinomas
Authors: Torii Akihito , Nonami Toshiaki , Harada Akio , Yasui Motoshi , Nakao Akimasa , Takagi Hiroshi 
Published: February 2007

AbstractThe prognostic factors for solitary hepatocellular carcinomas with a maximum tumor diameter of ⩽3 cm were investigated in 59 of 231 patients who underwent curative hepatic resections at the Department of Surgery II, Nagoya University Hospital between January 1981 and December 1991. The 3‐ and 5‐year survival rates of these 59 patients were 61% and 41%, respectively. As prognostic factors, tumor maximum diameter, vascular invasion, capsule formation, cell differentiation, tumor localization, hepatic functional reserve, extent of hepatic resection, and macroscopic surgical margin were selected in this study. Of the patients with a tumor size > 1.5 cm, those who underwent major hepatic resections (hepatic lobectomy or segmentectomy) tended to have better survival than patients who received minor hepatic resections (hepatic subsegmentectomy or limited resection). Although most patients with a tumor size ⩽1.5 cm underwent minor hepatic resections, they had a good survival rate. According to Cox's multivariate analysis, the extent of hepatic resection was significantly correlated with long‐term prognosis of patients with a solitary hepatocellular carcinoma ⩽3 cm in diameter, but the macroscopic surgical margin was not. Cell differentiation, vascular invasion, capsule formation, and tumor localization were all correlated with the long survival. These results suggest that the selection of an adequate operative procedure is an important factor for the long‐term prognosis of patients with small, solitary hepatocellular carcinomas. © 1993 Wiley‐Liss, Inc.
Local control following therapeutic nodal dissection for melanoma
Authors: Monsour Paul D. , Sause William T. , Avent James M. , Noyes R. Dirk 
Published: February 2007

AbstractRegional recurrence of melanoma is usually treated with surgical resection alone. Unfortunately sites of failure following surgical resection are poorly documented. Little information exists regarding local failure following surgery. In order to define local control, a retrospective analysis was performed of all patients undergoing a potentially curative lymph node dissection for metastatic melanoma. From 1978 to 1988, 48 patients underwent lymph node dissection with removal of all known disease (15 axillary, 25 groin and 8 radical neck dissections). Seven patients had stage II disease with simultaneous resection of the primary lesion and nodal dissection. The remaining 41 patients had stage I disease with dissection delayed until nodal metastasis became apparent. Of these 48 patients, 25 experienced local failure for an overall local control rate of 48%. Univariate and multivariate analysis showed only age to be a statistically significant prognostic indicator of local failure with a rate of 31% for patients >50 years of age vs. 66% for patients >50 years of age (P= 0.02). Nodal size, number of nodes involved, extracapsular extension, initial stage, location, or sex did not influence prognosis. Although not statistically significant, time to recurrence was much shorter in patients with extracapsular extension, 5 months vs. 16 months. With an overall local failure rate of 52% following a potentially curable therapeutic nodal dissection further local treatment should be considered. © 1993 Wiley‐Liss, Inc.
Head and neck synovial sarcomas
Authors: Pai Sanjay , Chinoy Roshan F. , Pradhan Sultan A. , D'cruz Anil K. , Kane Shubhada V. , Yadav Jyoti N. 
Published: February 2007

AbstractEleven cases of synovial sarcoma of the head and neck are analyzed. Patients presented with a mass either in the parapharynx, pharyngeal wall, or nape of the neck. The tumors ranged in size from 3 to 8 cm. Microscopically, the classic biphasic pattern was seen in 10 tumors. Immunohistochemistry and electron microscopy were useful in the diagnosis of the single monophasic variant of synovial sarcoma. Radical surgery was the mainstay of treatment with post‐operative radiotherapy for residual disease. Five patients were dead of disease while 6 were alive for periods varying from 9 months to 15 years. The purpose of this presentation is to accrue data on this sarcoma at a rare site, and to highlight the histopathological differential diagnosis, which includes both carcinomas and sarcomas. Treatment decisions would be affected by the histology report. © 1993 Wiley‐Liss, Inc.
Synergistic antitumor activity of mitomycin C and cisplatin against gastric cancer cells in vitro
Authors: Saikawa Yoshiro , Kubota Tetsuro , Kuo Tsong‐Hong , Kase Suguru , Furukawa Toshiharu , Tanino Hirokazu , Ishibiki Kyuya , Kitajima Masaki 
Published: February 2007

AbstractThe synergistic antitumor activity of mitomycin C (MMC) and cisplatin (DDP) against the gastric cancer cell lines MKN‐28 and MKN‐45 was assessed in vitro using the MTT assay. The synergism of the two agents was evaluated in terms of the interaction index (I.I.). The sequence of MMC followed by DDP showed higher antitumor activity than the reverse sequence against MKN‐28 and MKN‐45, and the intracellular concentration of platinum was significantly increased in MKN‐45 by preincubation with MMC, suggesting that MMC modulates cellular permeability to DDP or the ability of DDP to intercalate DNA. Since these two antitumor agents show different types of toxicity clinically, i.e., myelotoxicity by MMC and nephrotoxicity by DDP, this combination chemotherapy could be advantageous by providing synergistic antitumor activity without increased toxicity. © 1993 Wiley‐Liss, Inc.
Utility of the neodymium:yttrium‐aluminum‐garnet (Nd:YAG) laser for extensive pulmonary metastasectomy
Authors: Harvey James C. , Lee Kenneth , Beattie Edward J. 
Published: February 2007

AbstractThe neodymium:yttrium‐aluminum‐garnet (Nd:YAG) laser has been reported to have advantages in pulmonary resections including superior control of bleeding and air leak with relative sparing of pulmonary parenchyma. Extensive metastasectomies were performed in two patients with bilateral metastases who might have been excluded from surgery with other techniques. The patients were discharged within 8 days after uneventful postoperative courses. While this modality shows promise in permitting extensive metastasectomy, only long‐term follow‐up will demonstrate the ability to provide results comparable to those achieved with previous techniques. © 1993 Wiley‐Liss, Inc.
Vulvar carcinoma with 0.5 mm of invasion and associated inguinal lymph node metastasis
Authors: Hicks Michael L. , Hempling Ronald E. , Piver M. Steven 
Published: February 2007

AbstractA case of vulvar carcinoma with 0.5 mm of invasion treated by radical wide local excision only, which later developed ipsilateral inguinal lymph node recurrence, is presented. This represents the least amount of invasion reported resulting in inguinal lymph node metastasis. Review of the literature of stage I vulvar carcinoma with less than 1 mm of invasion indicates that this phenomenon occurs in only 1.6% of all patients who have undergone inguinal lymphadenectomy. Although this represents the second report of ipsilateral inguinal nodal metastasis associated with less than 1 mm of invasion, we continue to perform radical wide local excision without ipsilateral inguinal lymphadenectomy until more cases demonstrate a higher incidence of lymph node involvement. © 1993 Wiley‐Liss, Inc.
The role of suprahyoid block dissection in carcinoma of the floor of the mouth
Authors: Hudson Donald Anthony , Stannard Claire E. , Binnewald Bertram , Price Bernard 
Published: February 2007

AbstractThe efficacy of suprahyoid block dissection combined with radiotherapy, in the management of neck nodal disease was evaluated in 15 patients with carcinoma of the floor of mouth (abutting on the mandible) between 1983 and 1989. Ten males and 5 females had a mean age of 60.3 years. Suprahyoid block dissection was performed in 10 patients as initial treatment. Nine of these presented with a submandibular mass and one patient with a T4NO lesion had a prophylactic block performed. Suprahyoid block dissection was performed in five patients who developed a submandibular mass after completion of surgery and radiotherapy. Wound sepsis occurred in three patients, but resolved with conservative treatment. Clinical assessment of the suprahyoid mass was accurate in 65% of patients. Nodal recurrence occurred in one patient. Seven patients are alive and disease free after a mean of 64.5 months. Two other patients are alive, one with lung metastases, and one with a supraclavicular mass. Six patients have died, two of whom developed local recurrence, one who developed a supraclavicular mass, one after nodal recurrence, one with lung metastases, and one of an unrelated cause. Suprahyoid block dissection combined with radiotherapy is effective treatment for nodal control of patients with carcinoma of the floor of mouth. This procedure is associated with a low morbidity. © Wiley‐Liss, Inc.
Nutritional support and prognosis in patients with head and neck cancer
Authors: Lopez Marvin J. , Robinson Pat , Madden Tim , Highbarger Toni 
Published: February 2007

AbstractWe retrospectively studied the relationship between nutritional status as indicated by the presence or absence of the cutaneous delayed hypersensitivity response and treatment‐related morbidity, disease recurrence, and survival at 2 years in 67 consecutive patients with head and neck carcinoma. Serial nutritional assessments were conducted throughout the course of combined initial antineoplastic treatment and nutritional support. The presence of cell‐mediated immunity at the end of treatment was associated with a 2‐year survival rate of 100%, whereas patients who were anergic at the end of treatment had a 2‐year survival rate of 48% (P < 0.01). Morbidity due to surgical therapy and tumor recurrence rates were also higher in the anergic group (P < 0.01). Prognosis in head and neck cancer is based on many factors, but vigorous nutritional support during initial treatment may have some effect on morbidity, tumor recurrence, and survival time. © Wiley‐Liss, Inc.
Fine‐needle aspiration biopsy of pancreatic ductal adenocarcinoma: Loss of diagnostic accuracy with small tumors
Authors: Graham Roger A. , Bankoff Mark , Hediger Roy , Shaker Hassan Z. , Reinhold Randolph B. 
Published: February 2007

AbstractEighty‐three patients underwent CT‐directed fine‐needle aspiration biopsies (FNAB) for pancreatic ductal adenocarcinoma. Five factors that might have influenced the diagnostic sensitivity of FNAB were analyzed: clinical history, the number of passes for each FNAB, and three radiologic criteria including tumor size, tumor location, and the presence or absence of suspected tumor necrosis by CT scan. Sixty‐three patients had a diagnosis of pancreatic carcinoma confirmed by FNAB (overall sensitivity = 76%). Tumor size was the only factor that correlated with the diagnostic sensitivity of FNAB.

Of 12 patients whose FNAB was negative but suspicious for malignancy, 10 had a repeat FNAB and 4 were positive for carcinoma. We conclude that the diagnostic sensitivity of FNAB decreases significantly with decreasing tumor size and that a repeat FNAB for suspicious biopsies should be done to increase the diagnostic yield. © Wiley‐Liss, Inc.
Malignant peripheral nerve sheath tumors of the head and neck: A clinicopathological study
Authors: Vege Durga Swaroop , Chinoy Roshan Farokh , Ganesh Balasubramaniam , Parikh Deepak Mukund 
Published: February 2007

AbstractTwenty‐seven cases of malignant peripheral nerve sheath tumors involving the head and neck region over a period of 7 years were reviewed. They were graded from 1–3 based on necrosis, mitosis, cellularity, and pleomor‐phism. Mean age of occurrence was 42 years, with a range of 12–70 years. Male preponderance was noted (M:F = 3.5:1). The most common site of involvement was the neck (44.6%). The main presenting symptom was an enlarging mass. The nerve of origin could be identified in 33% of patients. Treatment consisted of wide excision. The 5‐year observed survival was 33%. Fifty‐two percent of patients developed local recurrence of disease. Fifteen percent of patients died due to advanced local disease within 18 months of treatment. Distant metastasis was seen in 18.5% of patients. Lymph node metastasis was not seen. At the end of 5 years 15% of patients remained disease free. Large tumor size (>5 cm) adversely affected the prognosis (P = < 0.1). No significant correlation was noted between the grade of tumor and survival. © Wiley‐Liss, Inc.
Osteomyocutaneous flap reconstruction for major mandibular defects
Authors: Savant Dhairyasheel N. , Kavarana Naozer M. , Bhathena Hosi M. , Salkar Shekhar , Ghosh Sudeep 
Published: February 2007

AbstractMandibular defects after composite resections for carcinoma of the buccal mucosa require immediate restitution of both form and function with an acceptable cosmetic result. The pectoralis major osteomyocutaneous flap (PM‐OMC) provides restoration of bone, soft tissue and skin with minimum morbidity. The procedure is technically simple, and in our series reconstruction using this flap has been performed by consultants, fellows and residents in training. We present a series of 116 PM‐OMC flaps with good postoperative mastication in more than 70% of cases, and satisfactory swallowing and intelligible speech in 85% patients. © Wiley‐Liss, Inc.