bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical significance of postoperative cardiothoracic ratio for postoperative pleural effusion following hepatectomy
Authors: Sakamoto Akimasa , Sakamoto Katsunori , Hikida Takahiro , Ito Chihiro , Iwata Miku , Shine Mikiya , Uraoka Mio , Nagaoka Tomoyuki , Honjo Masahiko , Tamura Kei , Funamizu Naotake , Ogawa Kohei , Takada Yasutsugu 
Published: March 2024

Abstract
Background: Although several preoperative risk factors for postoperative pleural effusion (POPE) after hepatectomy have been reported, few postoperative predictors have been investigated. We aimed to examine risk factors for clinically relevant POPE (CR-POPE) and whether cardiothoracic ratio (CTR) could be a predictive factor.
Methods: Participants in this retrospective investigation comprised 382 patients who underwent hepatectomy between January 2012 and December 2021. Perioperative characteristics that were considered potential risk factors for CR-POPE were evaluated. CR-POPE was defined as having undergone thoracentesis or thoracic drain placement.
Results: Patients were divided into a CR-POPE group (n = 38; 10.0%) and a non-CR-POPE group (n = 344; 90.0%). The CR-POPE group showed significantly higher intraoperative infusion volume (P < 0.001) and lower intraoperative urine volume (P = 0.015). In multivariate analysis, abdominal incision with a reversed L-shape or inverted T-shape (odds ratio [OR] = 3.07, P = 0.023], estimated blood loss >772 g (OR = 2.71, P = 0.049), diaphragm incision (OR = 8.31, P = 0.008), major postoperative complications excluding CR-POPE (OR = 7.99, P < 0.001), intraoperative infusion volume per body weight > 80 mL/kg (OR = 4.80, P = 0.007) and CTR on postoperative day (POD)1 >59.0% (OR = 4.34, P = 0.001) were all independently associated with occurrence of POPE.
Conclusion: We clarified risk factors for CR-POPE following hepatectomy. The occurrence of CR-POPE might be predictable from the CTR on POD1.
Breastfeeding and family history of atopy as predictors of clinical course for acute uncomplicated bronchiolitis in infants: a prospective, longitudinal, cohort study.
Authors: Sánchez Pablo Francisco Oliva - , Álvarez Alejandro Villagomez - , Levin Samuel Grobeisen - , Trejo Diego Arturo Velázquez - , Cueto Eduardo Bustillo - Del , Prado Rodrigo Vázquez - , Ortega Felipe Vadillo - 
Published: March 2024

Abstract
Background: Acute bronchiolitis (AB) is the most common lower airway disease in infants. The high incidence of this pathology and the risk of severe complications make it necessary to identify prognostic factors. The aim of this study was to determine whether there is an association between a family history of atopy and breastfeeding for more than six months and clinical outcomes in patients with AB.
Methods: This was a prospective, longitudinal cohort study. Patients who visited the emergency department of the General Hospital of Cuautitlán from October 1, 2020, to January 31, 2021 were included. Data collection was performed by means of a questionnaire with open-ended questions. Oxygen saturation data were collected at admission at 6, 12, 24, 24, 48, 72 and 120 hours.
Results: A sample of 108 participants was analyzed. We found a decrease of -3.69% (p=0.005, 95% CI: -6.24, -1.14) in oxygen saturation at admission in participants with a history of paternal atopy and an increased risk for hospitalization. Breastfeeding increased SaO2 by 2.41% (p=0.001, 95% CI: 1.02, 3.81) but was also a protective factor against hospitalization (OR=0.13, p=0.001 95% CI: 0.041 - 0.44).
Conclusions: A history of paternal atopy is a poor prognostic factor for the clinical course of AB. Breastfeeding proved to be a protective factor.
Prediction-based multi-objective optimisation method for 3D Printing Resource Consumption
Authors: Yang Jimeng , Wang Feibo , Dun Yiheng , Huang Zhipeng , Zhang Andi , Liu Ying 
Published: March 2024

Abstract

A prediction-based multi-objective optimisation (PBMO) method is proposed for 3D printing (3DP) technology to predict and reduce resource requirements on-demand, including time, energy and material. In the authors’ previous research work, a hybrid code-based and data-driven modelling (HCDM) scheme has been proposed to forecast 3DP resource consumption. The predictive models are customised based on process parameters, material deposition paths and machine behaviours. Aiming at the appropriate process parameters that consume the least resources, this study further utilises the models as three objectives to be minimised. Meta-heuristic algorithm is adopted to construct the optimisation framework, in which the HCDM process is embedded in the fitness evaluation step. To validate the proposed method, the corresponding computing program is compiled using Non-dominated Sorting Genetic Algorithm II (NSGA-II) and demonstrated on two material extrusion (MEX) machines. Hypervolume is used as the Lebesgue measure to evaluate the superiorities of near-optimal solutions on the non-dominated Pareto front. In three-dimensional objective space, the solution set that occupies the maximum hypervolume will be recommended as the optimal-found solutions for 3DP. In addition to 3DP, the proposed optimisation method is applicable to mainstream computer numerical control (CNC) manufacturing technologies, and will guide process design to promote resource conservation for cleaner production.
Neoadjuvant Combination Immunotherapy for Colorectal Cancer: Clinical and Molecular Predictors of Pathological Complete Response and Safety Assessment
Authors: Li Yuegang , Zhuang Meng , Mei Shiwen , Hu Gang , Zhao Wei , Qiu Wenlong , Wang Xishan , Tang Jianqiang 
Published: March 2024

Abstract
Purpose
To identify the clinical and molecular factors that effectively predict pathological complete response (pCR) and assess the safety of patients receiving neoadjuvant combination immunotherapy.
Materials and Methods
This retrospective study evaluated 81 patients with colorectal cancer (CRC) at a Chinese tertiary center between 2015 and 2023. The cohort included 24 patients with deficient mismatch repair (dMMR) tumors and 57 patients with proficient mismatch repair (pMMR) tumors. Patients were treated with a neoadjuvant combination of immunotherapy and surgery.
Results
We enrolled 81 patients who were divided into pCR (39.3%) and non-pCR (79.7%) groups. The factors significantly associated with a higher pCR rate after neoadjuvant combination immunotherapy were younger age, low carcinoembryonic antigen (CEA) level, high tumor mutational burden (TMB) level before treatment, clinical stage III, absence of lymph node metastasis before treatment, MSI-H level, dMMR, and pole status mutation. Preoperative combined chemotherapy and targeted therapy also influenced the pCR rate. Neoadjuvant combination immunotherapy showed an overall adverse event (AE) rate of 29.6%, with none of grades 3–4. Surgery-related adverse reactions (srAEs) were also absent for grades 3–4, and 14 of the 81 patients experienced grade 1–2 AEs.
Conclusion
Neoadjuvant combination immunotherapy resulted in a favorable pCR rate in patients with CRC. Young age, pretreatment CEA level, TMB level, clinical stage, lymph node metastasis, MSI, MMR, and pole status can be used as indicators of the efficacy of neoadjuvant combination immunotherapy. The incidence of AEs from neoadjuvant combination immunotherapy and surgery was low, indicating that this regimen is safe and feasible.
Spin current control of magnetism
Authors: Chen Lin , Sun Yuhan , Mankovsky Sergiy , Meier Thomas , Kronseder Matthias , Ebert Hubert , Weiss Dieter , Back Christian 
Published: March 2024

Abstract

Exploring novel strategies to manipulate the order parameter of magnetic materials by electrical means is of great importance, not only for advancing our understanding of fundamental magnetism, but also for unlocking potential practical applications. A well-established concept to date uses gate voltages to control magnetic properties, such as saturation magnetization, magnetic anisotropies, coercive field, Curie temperature and Gilbert damping, by modulating the charge carrier population within a capacitor structure1-5. Note that the induced carriers are non-spin-polarized, so the control via the electricfield is independent of the direction of the magnetization. Here, we show that the magnetocrystalline anisotropy (MCA) of ultrathin Fe films can be reversibly modified by a spin current generated in Pt by the spin Hall effect. The effect decreases with increasing Fe thickness, indicating that the origin of the modification can be traced back to the interface. Uniquely, the change in MCA due to the spin current depends not only on the polarity of the charge current but also on the direction of magnetization, i.e. the change in MCA has opposite sign when the direction of magnetization is reversed. The control of magnetism by the spin current results from the modified exchange splitting of majority- and minority-spin bands, and differs significantly from the manipulation by gate voltages via a capacitor structure, providing a functionality that was previously unavailable and could be useful in advanced spintronic devices.
Cardiovascular autonomic failure in hereditary transthyretin amyloidosis and TTR carriers is an early and progressive disease marker
Authors: Chiaro Giacomo , Stancanelli Claudia , Koay Shiwen , Vichayanrat Ekawat , Ingle Gordon T , McNamara Patricia , Carr Aisling , Wechalekar Ashutosh D , Whelan Carol J , Gillmore Julian , Hawkins Philip , Reilly Mary M , Mathias Christopher J , Iodice Valeria 
Published: March 2024

Abstract

Background. The cardiomyopathic and neuropathic phenotype of hereditary transthyretin amyloidosis are well recognized. Cardiovascular autonomic dysfunction is less systematically and objectively assessed.
Methods. Autonomic and clinical features, quantitative cardiovascular autonomic function, and potential autonomic prognostic markers of disease progression were recorded in a cohort of individuals with hereditary transthyretin amyloidosis and in asymptomatic carriers of TTR variants at disease onset (T0) and at the time of the first quantitative autonomic assessment (T1). The severity of peripheral neuropathy and its progression was stratified with the polyneuropathy disability score.
Results. A total of 124 individuals were included (111 with a confirmed diagnosis of hereditary transthyretin amyloidosis, and 13 asymptomatic carriers of TTR variants). Symptoms of autonomic dysfunction were reported by 27% individuals at T0. Disease duration was 4.5 ± 4.0 years (mean ± SD) at autonomic testing (T1). Symptoms of autonomic dysfunction were reported by 78% individuals at T1. Cardiovascular autonomic failure was detected by functional testing in 75% individuals and in 64% of TTRcarriers. Progression rate from polyneuropathy disability stages I/II to III/IV seemed to be shorter for individuals with autonomic symptoms at onset (2.33 ± 0.56 versus 4.00 ± 0.69 years [mean ± SD]).
Conclusions. Cardiovascular autonomic dysfunction occurs early and frequently in individuals with hereditary transthyretin amyloidosis within 4.5 years from disease onset. Cardiovascular autonomic failure can be subclinical in individuals and asymptomatic carriers, and only detected with autonomic function testing, which should be considered a potential biomarker for early diagnosis and disease progression.
Assessment of Color Effect in Cadmium and Lead Content in the Most Popular Cosmetics Sold in Saudi Market
Authors: Albugami Mashael M. , Buzaid Alyah , Shah Faheem , Ahmed Amel Y. 
Published: March 2024

Abstract
This study focuses to decide the concentration of lead (Pb) and cadmium (Cd) in some colored cosmetic products of four types (lipstick, blusher, eyeshadow, and hair dye) available at local markets in Saudi Arabia.48 cosmetic samples were analysed using inductively coupled plasma optical emission spectrometry (ICP-OES) to measure the content of Pb and Cd.Quality control of the data was achieved by the analysis of Hay Powder, IAEA-V-10 standard reference material from IAEA. The results show that the concentration of Pb in the lipstick, blusher, eyeshadow, and hair dye was within the range of 0.052–2.823, 0.204–1.097, 1.100-2.519 and 0.142–0.187 ppm, respectively, while the concentration of Cd was within the range of 0.001–0.071, 0.003–0.019, 0.022 − 0.0061 and 0.000-0.001 ppm, respectively. The effect of color on concentration was also investigated. The results of this study were compared with those of the previous studies. According to Saudi Standards, Metrology and Quality Organization (SASO) and the United States Food and Drug Administration (US FDA), the concentration of Pb and Cd in all samples that were examined were within the permissible levels. Results derived from the utilization of Hazard Quotient (HQ) indices show that Pb had the highest HQ values while Cd had the lowest values in all cosmetics under study. In addition, the hazard index (HI) for lipstick, blusher, eyeshadow, and hair day ranged from 0.02 t- 1.179, 0.08–0.457, 0.459–1.375, and 0.059–0.077, respectively.
A graph theory approach to heuristic generation of cyclic permutations
Authors: Freyre-Echevarría Alejandro , Rodríguez-Aulet Ramses , Alfonso-Peñate Adrián 
Published: March 2024

Abstract

The design of substitution boxes (S-boxes) used in block ciphers to resist linear, differential and algebraic cryptanalysis is a wide studied field in cryptography today. In this paper, we present a graph representation of S-boxes combined with optimization algorithms to produce cryptographically strong full cycle permutations. Furthermore, some results related to these permutations are analyzed from their graph representation.
A novel variant in the GNE gene in a Malian patient presenting with distal myopathy
Authors: KOTIOUMBE Mahamadou , Maiga Alassane B. , Bamba Salia , Cissé Lassana , Diarra Salimata , Diallo Salimata , Yalcouyé Abdoulaye , Kané Fousseyni , Diallo Seybou H. , Coulibaly Dramane , Coulibaly Thomas , Dembélé Kékouta , Maiga Boubacar , Guinto Cheick O. , Landouré Guida 
Published: March 2024

Abstract
Background: GNE myopathy (GM) is a rare autosomal recessive disorder caused by variants in the GNE gene and characterized by progressive distal muscle weakness and atrophy. We report a novel variant in theGNE gene causing GM in a consanguineous Malian family.
Case presentation: A 19-year-old male patient from a consanguineous family of Bambara ethnicity was seen for progressive walking difficulty and frequent falls. Neurological examination found distalmuscle weakness and atrophy and reduced tendon reflexes in four limbs. Electroneuromyography (ENMG) showed an axonal neuropathy pattern with reduced distal motor amplitudes. Charcot-Marie-Tooth (CMT) gene panel testing (Medical Neurogenetics LLC, Atlanta, GA) was negative. However, whole exome sequencing (WES) revealed a novel biallelic variant in GNE (c.1838G>A:p.Gly613Glu), segregating with the phenotype in the family. This variant is predicted to be pathogenic by several in silicoprediction tools including CADD= 29. Moreover, protein folding model showed major structural disruptions in the mutant protein.
Conclusion: This study reports a novel variant in the GNE gene causing GM, the first molecularly diagnosed in sub-Saharan Africa (SSA). It highlights the diagnosis challenges in this region and broadens the genetic spectrum of this rare disease.
Angiopoietin-Like Protein 2 Inhibits Thrombus Formation
Authors: Zhang Tiantian , Zhang Mingliang , Guo Lingyu , Liu Dongsheng , Zhang Kandi , Bi Changlong , Zhang Peng , Wang Jin , Fan Yuqi , He Qing , Chang Alex C. Y. , Zhang Junfeng 
Published: March 2024

Abstract

Backgroud: Acute myocardial infarction is mainly caused by a lack of blood flood in the coronary artery. Angiopoietin-like protein 2 (ANGPTL2) induces platelet activation and thrombus formation in vitro through binding with immunoglobulin-like receptor B, an immunoglobulin superfamily receptor. However, the mechanism by which it regulates platelet function in vivo remains unclear. Methods: In this study, we investigated the role of ANGPTL2 during thrombosis in relationship with ST-segment elevation myocardial infarction (STEMI) with spontaneous recanalization (SR). In a cohort of 276 male and female patients, we measured plasma ANGPTL2 protein levels. Using male Angptl2-knockout and wild-type mice, we examined the inhibitory effect of Angptl2 on thrombosis and platelet activation both in vivo and ex vivo. Results: We found that plasma and platelet ANGPTL2 levels were elevated in patients with STEMI with SR compared to those in non-SR (NSR) patients, and was an independent predictor of SR. Angptl2 deficiency accelerated mesenteric artery thrombosis induced by FeCL3 in Angptl2–/– compared to WT animals, promoted platelet granule secretion and aggregation induced by thrombin and collogen while purified ANGPTL2 protein supplementation reversed collagen-induced platelet aggregation. Angptl2 deficiency also increased platelet spreading on immobilized fibrinogen and clot contraction. In collagen-stimulated Angptl2–/– platelets, Src homology region 2 domain–containing phosphatase (Shp)1-Y564 and Shp2-Y580 phosphorylation were attenuated while Src, Syk, and Phospholipase Cγ2 (PLCγ2) phosphorylation increased. Conclusion: Our results demonstrate that ANGPTL2 negatively regulated thrombus formation by activating ITIM which can suppress ITAM signaling pathway. This new knowledge provides a new perspective for designing future antiplatelet aggregation therapies.
Pedestrian Gap Acceptance Behavior at Un-Signalized Intersections under Mixed Traffic Conditions- A Case Study at Dukem City, Ethiopia
Authors: Shanko Samuel Sileshi , Reddy Raju Ramesh , Torban Jiregna Chalchisa 
Published: March 2024

Abstract

Transportation System is the most convenient type of making several arrangements for both vehicles and pedestrians to achieve a smooth flow of traffic on the road. The provision of appropriate pedestrian facilities at the desired location as well as increased pedestrian safety while crossing the road are the main goals of the analysis of pedestrians at Un-Signalized crossroads. In Dukem City, one pedestrian follows the other pedestrians at Un-Signalized intersections when crossing the road. The present study is aimed to model and analysis the gap acceptance behavior of pedestrians at Un-Signalized intersections under mixed traffic conditions in Dukem City. Three Un-signalized Intersections namely ‘Qera’, ‘Qayamba’, ‘Misraq ber’ in Dukem city has been selected on the bases of pilot study and pedestrian- traffic data at the study area. Pedestrian Gap acceptance studies are conducted at the selected study locations and the related data such as pedestrian volume, gaps accepted, rejected, their waiting time, age, gender, headway, traffic volume, speed and road geometry at the respective study locations are collected by video graphic method. A total number of 7200 pedestrian gaps are observed cumulatively in all the study locations, for the purpose of analysis and modeling. Multiple Regression Model is developed from the collected data to analyze the gap acceptance behavior of the pedestrians at un-signalized Intersections at the selected study locations in Dukem City. The developed model is validated and found good fitness with R2 value more than 0.9. The results obtained from the model may be useful for predicting the pedestrian behavior that will be useful to implement pedestrian safety measures at the selected locations. The maximum and minimum pedestrian waiting times recorded at the study locations are found to be varied between 59.9 sec to 16.8 sec respectively.
Evaluation of biomass and vegetative characteristics of mesquite (Prosopis juliflora) afforestation in arid area of Iran
Authors: Hosseinzadeh Jaafar , Heydari Mehdi , Ehsani Ahmad , Bazgir Masoud , Dey Daniel C. 
Published: March 2024

Abstract

Evaluating the degree of success in the growth, effectiveness and durability or replacement of pioneer afforestation in dry areas of the world is one of the important issues of managing these forests. We evaluated the suitability of mesquite for afforesting degraded lands in the dry climate region of Einkhosh, Ilam province, Iran by studying the influence of stand density (180 and 250 trees per ha) and age (15, 27 and 34 years) on tree development, growth and biomass, and soil quality in. We measured tree characteristics (height, crown height, collar diameter and crown area) and calculated above-ground biomass. Soil quality index was determined at two depths (0–15 and 15–30 cm) based on the measured physical, chemical and biological soil properties. The results showed that stand age and density and their interaction significantly affected stem number, crown height growth and soil quality index. The average number of stems was the highest (7.8 per hectare) in the 15-year-old stand and the lowest (1.5 per hectare) in the 34-year-old stand. Height, collar diameter, basal area growth, biomass, and competition between trees were significantly affected by stand age and its interaction with stand density (p < 0.01). The average annual growth of tree collar diameter and height with age was lowest (4.1 mm per year and 17.7 cm per year, respectively) in the 34-year-old stand. In contrast, average annual growth rates of 7.2 mm and 31 cm for collar diameter and height, respectively, in the 15-year-old stand. The surface soil quality index increased with the stand age and density, and it was highest (averaging 0.714) in the dense areas of the 34-year-old stand. In contrast, soil quality index at lower soil depths, decreased with increasing stand age, but it was still highest in the dense areas of the 34-year-old stand. The basal area at the stem collar showed a positive and strong correlation with total height, crown height, degree of competition and crown area. In general, high density mesquite afforestation plantings (250 trees per hectare) in this dry and desert area improved soil quality and increased vegetative and productivity characteristics of mesquite, especially as stands aged. Therefore, mesquite can be a suitable option for revitalization of sites in dry and sparsely vegetated areas.
ASTKD-PCB-LDD:A Lightweight High Performance PCB Defect Detection Algorithm
Authors: Hu Zhelun , Tang Lijun , Zhang Zhao , Liu Shenbo , Zhao Dongxue , Zheng Longhao 
Published: March 2024

Abstract
The YOLOv5 algorithm, widely utilized in printed circuit board (PCB) defect detection, undergoes a reduction in speed when deployed on compact industrial computing platforms due to its substantial parameter count. Consequently, this study proposes a lightweight and high-performance PCB defect detection model based on YOLOv5, named ASTKD-PCB-LDD.Employing the k-means++ algorithm for optimal anchor boxes and the SCYLLA-IoU(SIoU) loss function over the Complete IoU(CIoU) loss function, the model enhances accuracy in locating and detecting small-target defects.It designs the Faster-Ghost lightweight backbone network to replace the YOLOv5 backbone network, and employs a slim-neck neck architecture to supersede the YOLOv5 neck network, which significantly reduces computational requirements and enhances inference speed, yielding a more efficient PCB-LDD network. The align soft-target knowledge distillation(ASTKD) approach is crafted to employ the PCB-LDD model as the teacher and the pruned model (via the Layer-Adaptive Magnitude-based Pruning(LAMP)) as the student, aiming to preserve detection accuracy while reducing parameters. Experimental results demonstrate that the model size has been reduced from 14.5MB to 4MB, achieving a compression rate of 27.6%; the mean average precision (mAP) achieves 98%, and the detection speed is enhanced from 73.2 frames/s to 112.3 frames/s, resulting in a speedup of 153.4%. This approach successfully achieves the goal of combining high performance with lightweight design, significantly enhancing the accuracy and efficiency of PCB defect detection.