bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic variants and haplotype analyses of the ZBRK1/ZNF350 gene in high‐risk non BRCA1/2 French Canadian breast and ovarian cancer families
Authors: Desjardins Sylvie , Belleau Pascal , Labrie Yvan , Ouellette Geneviève , Bessette Paul , Chiquette Jocelyne , Laframboise Rachel , Lépine Jean , Lespérance Bernard , Pichette Roxane , Plante Marie ,   INHERIT BRCAs, Durocher Francine 
Published: August 2007

AbstractOur current understanding of breast cancer susceptibility involves mutations in the 2 major genes BRCA1 and BRCA2, found in about 25% of high‐risk families, as well as few other low penetrance genes such as ATM and CHEK2. Approximately two‐thirds of the multiple cases families remain to be explained by mutations in still unknown genes. In a candidate gene approach to identify new genes potentially involved in breast cancer susceptibility, we analyzed genomic variants in the ZBRK1 gene, a co‐repressor implicated in BRCA1‐mediated repression of GADD45. Direct sequencing of ZBRK1 entire coding region in affected breast cancer individuals from 97 high‐risk French Canadian breast/ovarian cancer families and 94 healthy controls led to the identification of 18 genomic variants. Haplotype analyses, using PHASE, COCAPHASE and HaploStats programs, put in evidence 3 specific haplotypes which could potentially modulate breast cancer risk, and among which 2 that are associated with a potential protective effect (p = 0.01135 and p = 0.00268), while another haplotype is over‐represented in the case group (p = 0.00143). Further analyses of these haplotypes indicated that a strong component of the observed difference between both groups emerge from the first 5 variants (out of 12 used for haplotype determination). The present study also permitted to determine a set of tagging SNPs that could be useful for subsequent analyses in large scale association studies. Additional studies in large cohorts and other populations will however be needed to further evaluate if common and/or rare ZBRK1 sequence variants and haplotypes could be associated with a modest/intermediate breast cancer risk. © 2007 Wiley‐Liss, Inc.
Alcohol consumption and endometrial cancer risk: The multiethnic cohort
Authors: Setiawan Veronica Wendy , Monroe Kristine R. , Goodman Marc T. , Kolonel Laurence N. , Pike Malcolm C. , Henderson Brian E. 
Published: August 2007

AbstractThe role of alcohol intake in the etiology of endometrial cancer is unclear. We examined the impact of alcohol intake on endometrial cancer risk among 41,574 postmenopausal African‐American, Japanese‐American, Latina, Native‐Hawaiian and White women recruited to the prospective Multiethnic Cohort Study in 1993–1996. During an average of 8.3 years of follow‐up, 324 incident invasive endometrial cancer cases were identified among these women. Data on alcohol intake and endometrial cancer risk factors were obtained from the baseline questionnaire. Relative risks (RRs) and 95% confidence intervals (CIs) for endometrial cancer associated with alcohol intake were estimated using log‐linear (Cox) proportional hazard models stratified by age, year of recruitment, ethnicity and study center, and adjusted for several confounding factors. Increased alcohol consumption was associated with increased risk (p trend = 0.013). Compared to nondrinkers, women consuming ≥2 drinks/day had a multivariate RR of 2.01 (95% CI: 1.30, 3.11). There was no increase in risk associated with <1 drink/day (RR = 1.01; 95% CI: 0.77, 1.33) and 1 to <2 drinks/day (RR = 1.09; 95% CI: 0.62, 1.93). There was no clear effect modification by body mass index, postmenopausal hormone use, parity, oral contraceptive use or smoking status, though our power to detect such interactions was limited. Our results suggest that only alcohol consumption equivalent to 2 or more drinks per day increases risk of endometrial cancer in postmenopausal women. © 2007 Wiley‐Liss, Inc.
Growth, technological interdependence and spatial externalities: theory and evidence
Authors: Ertur Cem , Koch Wilfried 
Published: August 2007

AbstractThis paper presents a theoretical growth model which explicitly takes into account technological interdependence among economies and examines the impact of spillover effects. Technological interdependence is assumed to operate through spatial externalities. The magnitude of the physical capital externalities at steady state, which is not usually identified in the literature, is estimated using a spatial econometric specification. Spatial externalities are found to be significant. This spatially augmented Solow model yields a conditional convergence equation which is characterized by parameter heterogeneity. A locally linear spatial autoregressive specification is then estimated providing a convergence speed estimate for each country of the sample. Copyright © 2007 John Wiley & Sons, Ltd.
Panel cointegration tests of the Fisher effect
Authors: Westerlund Joakim 
Published: August 2007

AbstractMost empirical evidence suggests that the Fisher effect, stating that inflation and nominal interest rates should cointegrate with a unit slope on inflation, does not hold, a finding at odds with many theoretical models. This paper argues that these results can be attributed in part to the low power of univariate tests, and that the use of panel data can generate more powerful tests. For this purpose, we propose two new panel cointegration tests that can be applied under very general conditions, and that are shown by simulation to be more powerful than other existing tests. These tests are applied to a panel of quarterly data covering 20 OECD countries between 1980 and 2004. The evidence suggest that the Fisher effect cannot be rejected once the panel evidence on cointegration has been taken into account. Copyright © 2007 John Wiley & Sons, Ltd.
Ectopic pregnancy in a cesarean section scar treated with intramuscular methotrexate and bilateral uterine artery embolization
Authors: Hois Erin L. , Hibbeln John F. , Alonzo Marc J. , Chen Meri E. , Freimanis Maija G. 
Published: August 2007

AbstractWe report a case of an ectopic pregnancy implanted in the myometrium at the site of a scar from a previous cesarean section that presented with vaginal bleeding and was successfully treated with bilateral uterine artery embolization and intramuscular administration of methotrexate. The combination of minimally invasive interventional techniques and medical therapies can preserve fertility. © 2007 Wiley Periodicals, Inc. J Clin Ultrasound, 2008
Non‐model‐based correction of respiratory motion using beat‐to‐beat 3D spiral fat‐selective imaging
Authors: Keegan Jennifer , Gatehouse Peter D. , Yang Guang‐Zhong , Firmin David N. 
Published: August 2007

AbstractPurposeTo demonstrate the feasibility of retrospective beat‐to‐beat correction of respiratory motion, without the need for a respiratory motion model.Materials and MethodsA high‐resolution three‐dimensional (3D) spiral black‐blood scan of the right coronary artery (RCA) of six healthy volunteers was acquired over 160 cardiac cycles without respiratory gating. One spiral interleaf was acquired per cardiac cycle, prior to each of which a complete low‐resolution fat‐selective 3D spiral dataset was acquired. The respiratory motion (3D translation) on each cardiac cycle was determined by cross‐correlating a region of interest (ROI) in the fat around the artery in the low‐resolution datasets with that on a reference end‐expiratory dataset. The measured translations were used to correct the raw data of the high‐resolution spiral interleaves.ResultsBeat‐to‐beat correction provided consistently good results, with the image quality being better than that obtained with a fixed superior–inferior tracking factor of 0.6 and better than (N = 5) or equal to (N = 1) that achieved using a subject‐specific retrospective 3D translation motion model.ConclusionNon‐model‐based correction of respiratory motion using 3D spiral fat‐selective imaging is feasible, and in this small group of volunteers produced better‐quality images than a subject‐specific retrospective 3D translation motion model. J. Magn. Reson. Imaging 2007;26:624–629. © 2007 Wiley‐Liss, Inc.
Myocardial tissue characterization and the role of chronic anemia in sickle cell cardiomyopathy
Authors: Westwood Mark A. , Shah Farrukh , Anderson Lisa J. , Strange Julian W. , Tanner Mark A. , Maceira Alicia M. , Howard Jo , John B. Porter  , Walker J. Malcolm , Wonke Beatrix , Pennell Dudley J. 
Published: August 2007

AbstractPurposeTo use cardiovascular magnetic resonance (CMR) techniques to examine possible causes for the left ventricular (LV) dilatation that occurs in sickle cell disease (SCD), including the effects of chronic anemia, iron‐induced cardiomyopathy, and regional fibrosis due to sludge infarcts that occur during sickle crises.Materials and MethodsA total of 47 patients with sickle cell anemia were assessed for LV function and myocardial iron levels using CMR measurements; 30 of these were also assessed for regional fibrosis using late gadolinium‐enhancement CMR. The LV function was compared to both normal controls and transfusion dependent non‐iron‐loaded (NIL) thalassemia major (TM) patients.ResultsOnly one SCD patient had significant myocardial iron loading, and only two patients had regional fibrosis. There were significant differences in ventricular volumes of the sickle patients compared with both the normal controls and the NIL‐TM population (P < 0.01).ConclusionThe LV changes seen in SCD are partly the result of a chronic anemia but there appears to be another contributory factor. This extra factor is not myocardial iron loading or regional fibrosis, although a homogenous fibrotic disorder affecting the left ventricle cannot be excluded. J. Magn. Reson. Imaging 2007;26:564–568. © 2007 Wiley‐Liss, Inc.
T2‐weighted cardiovascular magnetic resonance imaging
Authors: Abdel‐Aty Hassan , Simonetti Orlando , Friedrich Matthias G. 
Published: August 2007

AbstractTechnical advances in T2‐weighted cardiovascular MR (CMR) imaging allow for accurate identification and quantification of tissue injuries that alter myocardial T2 relaxation. Of these, myocardial edema is of special relevance. Increased myocardial water content is an important feature of ischemic as well as nonischemic cardiomyopathies, which are often associated with acute myocardial inflammation. In this article, we review technical considerations and discuss clinical indications of myocardial T2‐weighted imaging. J. Magn. Reson. Imaging 2007;26:452–459. © 2007 Wiley‐Liss, Inc.
Two‐dimensional fast imaging employing steady‐state acquisition (FIESTA) cine acquisition of fetal non–central nervous system abnormalities
Authors: Shen Shu‐Huei , Guo Wan‐Yuo , Hung Jeng‐Hsiu 
Published: August 2007

AbstractPurposeTo evaluate the value of two‐dimensional fast imaging employing steady‐state acquisition (2D FIESTA) cine MR with parallel imaging techniques in the diagnosis of fetal non–central nervous system (CNS) anomalies.Materials and MethodsA total of 28 pregnant women were referred for further MR evaluation on fetuses after abnormal sonographic results. A total of 33 fetal MR examinations were performed by a 1.5T MR scanner with eight‐channel phase‐arrayed body coils. Single‐shot fast spin‐echo (SSFSE®, GE) of three orthogonal planes and 2D FIESTA for cine fetal MR of three sagittal planes (midsagittal and 10 mm off midline on left and right) were routinely acquired. Additional planes on target organs with variable imaging frames were added if indicated.ResultsNine of the 33 examinations (9/33; 27.3%) had motion artifacts obscuring the detail in SSFSE imaging; 2D FIESTA imaging provided motion‐artifact‐free imaging in all of them. Cine 2D FIESTA imaging provided additional information on the visceral peristalsis. The information helped in differentiating dilated gastrointestinal (GI) tract from other intraabdominal cystic lesions and in confirming the nature and level of GI tract obstruction.ConclusionWith sub‐half‐second temporal resolution of the 2D FIESTA sequences, fetal movement is no longer problematic. In addition to the anatomical information also provided by conventional SSFSE sequences, 2D FIESTA demonstrates information on motility and peristalsis of hollow organs and helps the diagnosis of fetal visceral anomalies. J. Magn. Reson. Imaging 2007;26:672–677. © 2007 Wiley‐Liss, Inc.
Physiological changes of the human uterine myometrium during menstrual cycle: Preliminary evaluation using BOLD MR imaging
Authors: Kido Aki , Koyama Takashi , Kataoka Masako , Yamamoto Akira , Saga Tsuneo , Turner Robert , Togashi Kaori 
Published: August 2007

AbstractPurposeTo investigate the T2* values within the junctional zone and outer uterine myometrium and their changes during the menstrual cycle, and thus to evaluate their physiologic changes on blood oxygenation level‐dependent (BOLD) magnetic resonance (MR) imaging.Materials and MethodsSingle‐shot echo‐planar imaging (EPI) was used to acquire T2*‐weighted images (TR/TE = 1000 msec/23–150 msec) from 15 healthy females with a 1.5‐T magnet. T2* values of both junctional zone and outer uterine myometrium were measured within a single breathhold and during three menstrual cycle phases (menstrual, periovulatory, and luteal phase). Signal intensities of uterine myometrium on T2‐weighted images were also evaluated.ResultsT2* could successfully be calculated in 13 subjects. T2* values for the junctional zone were significantly lower than those of the outer myometrium at every phase(P < 0.001), and T2* values of both junctional zone (P < 0.05) and outer (P < 0.01). Myometrium in the menstrual phase was significantly lower than those in the other phases. On T2‐weighted images, the signal intensity of the junctional zone was significantly lower than outer myometrium in every phase (P < 0.01), but there was no significant difference among menstrual cycle phases in both layers (P > 0.05).ConclusionThis preliminary study suggested that menstrual cycle changes of the uterine myometrium were shown by BOLD imaging. BOLD MR imaging may be an potential modality to investigate physiologic changes of the uterine myometrium during the menstrual cycle. J. Magn. Reson. Imaging 2007. © 2007 Wiley‐Liss, Inc.
Manganese dipyridoxyl‐diphosphate (MnDPDP) as a viability marker in patients with myocardial infarction
Authors: Skjold Arne , Amundsen Brage H. , Wiseth Rune , Støylen Asbjørn , Haraldseth Olav , Larsson Henrik B.W. , Jynge Per 
Published: August 2007

AbstractPurposeTo evaluate contrast accumulation in left ventricular (LV) myocardium after manganese dipyridoxyl‐diphosphate (MnDPDP) administration in patients with recent first time myocardial infarction.Materials and MethodsMnDPDP (5 μmol/kg) was administered to 10 patients with recent myocardial infarction (three to 12 weeks). One slice of interest (SOI) likely to traverse the infarction was chosen, and sectorial pre‐ and postcontrast longitudinal relaxivity rates (R1) and signal changes during infusion were estimated with a fast gradient echo sequence. LV volume and wall thickening were measured in short‐axis cine recordings. Infarct localization from R1 and wall thickening data were compared by vector analyses.ResultsReduced wall thickening was associated with reduced precontrast R1 and reduced contrast enhancement. Both remote and infarcted regions showed rapid initial contrast accumulation. In remote regions, this was followed by a continuing slow increase. Mean precontrast R1 was 0.87 ± 0.06 second–1 in infarcted regions and 0.96 ± 0.03 second–1 in remote regions (P < 0.001). Mean R1 change over one hour was 0.24 ± 0.07 second–1 in infarcted regions and 0.38 ± 0.03 second–1 in remote regions (P < 0.0001).ConclusionRemote regions showed larger increases in R1 than infarcted regions. This is most likely due to selective and slow Mn accumulation in viable myocytes. J. Magn. Reson. Imaging 2007;26:720–727. © 2007 Wiley‐Liss, Inc.
Transperineal prostate biopsy under magnetic resonance image guidance: A needle placement accuracy study
Authors: Blumenfeld Philip , Hata Nobuhiko , DiMaio Simon , Zou Kelly , Haker Steven , Fichtinger Gabor , Tempany Clare M.C. 
Published: August 2007

AbstractPurposeTo quantify needle placement accuracy of magnetic resonance image (MRI)‐guided core needle biopsy of the prostate.Materials and MethodsA total of 10 biopsies were performed with 18‐gauge (G) core biopsy needle via a percutaneous transperineal approach. Needle placement error was assessed by comparing the coordinates of preplanned targets with the needle tip measured from the intraprocedural coherent gradient echo images. The source of these errors was subsequently investigated by measuring displacement caused by needle deflection and needle susceptibility artifact shift in controlled phantom studies. Needle placement error due to misalignment of the needle template guide was also evaluated.ResultsThe mean and standard deviation (SD) of errors in targeted biopsies was 6.5 ± 3.5 mm. Phantom experiments showed significant placement error due to needle deflection with a needle with an asymmetrically beveled tip (3.2–8.7 mm depending on tissue type) but significantly smaller error with a symmetrical bevel (0.6–1.1 mm). Needle susceptibility artifacts observed a shift of 1.6 ± 0.4 mm from the true needle axis. Misalignment of the needle template guide contributed an error of 1.5 ± 0.3 mm.ConclusionNeedle placement error was clinically significant in MRI‐guided biopsy for diagnosis of prostate cancer. Needle placement error due to needle deflection was the most significant cause of error, especially for needles with an asymmetrical bevel. J. Magn. Reson. Imaging 2007;26:688–694. © 2007 Wiley‐Liss, Inc.
Thigh muscle stiffness assessed with magnetic resonance elastography in hyperthyroid patients before and after medical treatment
Authors: Bensamoun Sabine F. , Ringleb Stacie I. , Chen Qingshan , Ehman Richard L. , An Kai‐Nan , Brennan Michael 
Published: August 2007

AbstractPurposeTo measure the stiffness of the vastus medialis (VM) in hyperthyroid patients before and after treatment.Materials and MethodsA total of five healthy euthyroid patients and five hyperthyroid patients were tested using magnetic resonance elastography (MRE), which involves the induction of shear waves in the thigh muscles using a pneumatic driver at 90 Hz.ResultsAmong the pretreatment hyperthyroid cohort a lower stiffness was found when the muscle was relaxed (2.11 ± 0.61 kPa) compared the stiffness following treatment of hyperthyroidism (5.52 ± 1.52 kPa), which was accompanied by an improvement in the contractile function of the VM. Pretreatment muscle stiffness was also less than that of age matched healthy volunteers (4.56 ± 0.40 kPa). The behavior of the waves was sensitive to the stage of this myopathy and to the amount of free thyroxine (FT4).ConclusionThe MRE technique provides a new tool to gain new insights into pathophysiology of thyroid associated and other muscle diseases and their response to treatment. J. Magn. Reson. Imaging 2007;26:708–713. © 2007 Wiley‐Liss, Inc.
Application of voxelwise analysis in the detection of regions of reduced fractional anisotropy in multiple sclerosis patients
Authors: Patel Sunil A. , Hum Barbara A. , Gonzalez Carlos F. , Schwartzman Robert J. , Faro Scott H. , Mohamed Feroze B. 
Published: August 2007

AbstractPurposeTo investigate the utility of voxelwise analysis in the detection of lesions in the normal appearing white matter (NAWM) of individual multiple sclerosis (MS) patients.Materials and MethodsDiffusion tensor imaging (DTI) was performed on 10 normal controls and six patients with MS lesions. The fractional anisotropy (FA) maps derived from the diffusion‐weighted images were then spatially normalized (via an affine transformation) into Montreal Neurological Institute (MNI) space, and the normalized FA map of each of the patients was compared voxelwise with the normalized FA maps of the group of normals in a one‐sample t‐test (P = 0.0001). Two independent board‐certified neuroradiologists reviewed the data.ResultsIn the patient data for all six cases, the two reviewers determined detection sensitivities of 72% and 96% for the voxelwise technique based on known fluid‐attenuated inversion‐recovery (FLAIR) lesions. In addition, between the two reviewers, nine NAWM regions exhibiting FA reductions were identified in the six patients. However, numerous regions of abnormal FA were detected that were attributed to poor intersubject image registration.ConclusionVoxelwise analysis of spatially normalized FA maps has the potential to identify regions of FA reduction in lesions and in the NAWM of individual MS patients in a rapid and reproducible fashion. J. Magn. Reson. Imaging 2007;26:552–556. © 2007 Wiley‐Liss, Inc.
Improved bulk myocardial motion suppression for navigator‐gated coronary magnetic resonance imaging
Authors: Jahnke Cosima , Nehrke Kay , Paetsch Ingo , Schnackenburg Bernhard , Gebker Rolf , Fleck Eckart , Nagel Eike 
Published: August 2007

AbstractPurposeTo evaluate the impact of a new, cross‐correlation based method for compensation of respiratory induced motion of the heart using an individually adapted three‐dimensional (3D) translation or affine transformation approach.Materials and MethodsA total of 32 patients underwent a routine cardiac MR examination. In each patient, a calibration scan was performed during free‐breathing to register breathing‐related motion within a 3D ellipsoid registration kernel covering the entire heart. Three navigators were employed for all three spatial dimensions (feet‐head, anterior‐posterior, and left‐right) and the optimal translatory correction factors for each spatial dimension were determined. In addition, the cross‐correlations for different motion models (no compensation, fixed 1D‐translation, adapted 3D‐translation, and affine transformation) were calculated.ResultsThe mean correction factor for the feet‐head direction was 0.45 ± 0.13. Though the mean correction factors for the anterior‐posterior and left‐right direction were nearly zero (–0.01 ± 0.08 and 0.02 ± 0.09, respectively), the correction factors exceeded the amount of 0.1 in 12 (19%) and in 19 patients (30%), respectively. All motion compensation models showed significantly higher cross‐correlations when compared to “no compensation” (P < 0.05). In particular, the affine transformation algorithm achieved the highest cross‐correlation values (88.3 ± 5.1%) with a significant increase compared to fixed 1D translation (84.7 ± 6.5%, P < 0.05).ConclusionA considerable number of patients demonstrated relevant breathing‐related movement of the heart in the anterior‐posterior or left‐right direction in addition to the predominant breathing‐related movement in the feet‐head direction. Thus, it is recommended to compensate for all three spatial dimensions. The affine transformation algorithm combined with three navigators significantly improved breathing‐related cardiac motion compensation when compared to the conventionally applied 1D translation with a fixed correction factor. J. Magn. Reson. Imaging 2007;26:780–786. © 2007 Wiley‐Liss, Inc.