bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peran Public Relations dalam Membangun Komunikasi Karyawan dan Pimpinan yang Konstruktif pada Perusahaan
Authors: Natasha Ismail Aisha , Setyanto Yugih 
Published: March 2024

In this research author analyzes the role of PR in building constructive internal communication at Megatama Internal company. Communication is an important thing that is needed in life, including for conveying ideas and messages, as well as conveying messages to understand each other, so communication is really needed in the company to create better relationships and build constructive communication. To build constructive communication Public Relations is needed to maintain good values ​​and mutual understanding between audiences. Public Relations divided by two audiences, one of which is internal Public Relations which serves as a liaison between audiences within the company, namely between management and employees so that there are no misunderstandings within a company. Therefore, the aim of this research is to determine the role of PR in building good internal communication. building between employees and leaders at the Megatama Internal company. This research uses qualitative research methods, interviews with internal parties, and connects it with interpersonal communication which has five aspects, namely Equality, Empathy, Expressiveness, Cooperation and Proximity. The conclusion of this research is to find out that Public Relations has four roles in trying to build constructive communication at the Megatama Internal company.
Dalam penelitian ini penulis memiliki tujuan menganalisis peran PR dalam membangun komunikasi internal yang konstruktif pada perusahaan Megatama Internal. Komunikasi merupakan hal penting yang diperlukan dalam kehidupan antara lain untuk penyampaian ide dan gagasan, juga penyampaian pesan agar saling memahami, maka komunikasi sangat dibutuhkan dalam perusahaan guna menjalin hubungan yang lebih baik dan membangun komunikasi yang konstruktif. Guna membangun komunikasi yang konstruktif pada perusahaan Megatama Internal Public Relations atau PR dibutuhkan untuk menjaga nilai baik dan saling pengertian antar khalayak. PR terbagi menjadi dua khalayak salah satunya merupakan internal PR yang bertugas sebagai penghubung antara khalayak di dalam perusahaan yaitu antara manajemen dan karyawan agar tidak terjadi kesalah pahaman pada suatu perusahaan. Oleh karena itu tujuan penelitian ini untuk mengetahui peran PR dalam membangun komunikasi internal yang konstruktif antara karyawan dan pimpinan pada perusahaan Megatama Internal. Penelitian ini menggunakan metode penelitian kualitatif, wawancara dengan pihak internal dan menghubungkan dengan komunikasi interpersonal yang mempunyai lima aspek yaitu Equality, Empathy, Expresiveness, Coorperation dan Immediacy Kesimpulan dari penelitian ini yakni untuk mengetahui bahwa Public Relations memiliki empat Peran dalam mencoba untuk membangun komunikasi yang konstruktif pada perusahaan Megatama Internal. yaitu communication, relationship,back up management dan good image maker untuk membangun komunikasi yang konstruktif.
Rectangular Plate Rebound Vibration Suppression using Double Collision Phenomena
Authors: Matsumoto Hiroki , Kawakita Kazuhiro 
Published: March 2024

The rectangular plate is a model of the internal mirror of an SLR camera. The internal mirror model is a rectangular metal plate that rotates on its own axis around one side of a rectangle. When the mirror hits to the stopper, a rebound vibration occurs. The double collision method is introduced to reduce the rebound vibration. The timing of the double collision varies the amount of rebound vibration. 3-D Particle Image Velocimetry (3-D PIV) and 3-D motion analysis are used to investigate the rebound phenomena. 3-D PIV measures the rebound vibration velocity of the mirror model surface at the moment of collision. 3-D motion analysis is used to measures the rebound vibration displacement at the moment of collision. When the rebound vibration is small, the low-velocity region on the surface of the mirror model moves in the longitudinal direction. This indicates that the mirror model is undergoing wave deformation after the moment of collision. When the timing of the second collision is optimized, the deformation of the mirror model at the moment of collision is increased and the rebound amount is suppressed.
SISTEM PENGELOLAAN DAN POTENSI TEGAKAN HUTAN RAKYAT KECAMATAN NUSAHERANG KABUPATEN KUNINGAN
Authors: Ismail Agus Yadi , Syafrudin Oding , Yutika Yudi 
Published: March 2024

Hutan rakyat adalah hutan yang tumbuh diatas lahan yang dibebani hak milik, jadi hutan rakyat adalah hutan yang dimiliki oleh rakyat (Undang-Undang pokok Kehutanan No. 41 Tahun 1999). Tujuan dari penelitian ini adalah untuk mempelajari dan mengidentifikasi sistem pengelolaan, potensi tegakan dan manfaat ekonomi dari kegiatan pengelolaan hutan rakyat di Desa Cikadu Kecamatan Nusaherang Kabupaten Kuningan. Penelitian ini diperoleh dari metode field observation, metode sampling dan metode wawancara terhadap petani responden.Sistem pengelolaan hutan rakyat di Desa Cikadu masih bersifat sederhana, Pengelolaan hutan rakyat di Desa Cikadu dilakukan dengan menggunakan sistem agroforestry dengan tanaman semusim dan model agroforesty dengan tanaman perkebunanHasil penelitian menunjukkan bahwa sebagian besar responden petani hutan. Petani responden mendapatkan bibit dengan cara membeli dan dilakukan proses seleksi untuk mendapatkan bibit yang bermutu. Pemanenan kayu dengan cara sistem tebang pilih dengandiameter pohon yang sudah mencapai 20-50 cm. Pemasaran kayu dilakukan dengan sistem tebasan oleh pengepul yang berasal dari Desa Cikadu.Potensi pengelolaan hutan rakyat di Desa Cikadu dengan luas hutan rakyat dari seluruh petani responden 11,21 Ha, memiliki potensi kayu Sengon (Paraserianthes falcataria) 13,60 m3/ha dan Mahoni (Swietenia mahagoni) 23,87 m3/ha dan afrika (Meosopsi eminii)12,83 m3/ha. Dengan potensi usaha Hutan Rakyat desa Cikadu untuk mahoni Rp.29.150.000/tahun, untuk sengon Rp.16.580.000/tahun dan untuk afrika Rp. 24.450.000/tahun,cengkeh (Syzygium auromaticum) Rp. 234.000/tahun, sedangkan kontribusi pendapatan terkecil diperoleh dari kopi (Coffea robusta) Rp. 156.600/tahun.Kata Kunci : Hutan rakyat, Sistem pengelolaan hutan rakyat , Potensi tegakan kayu, Kontribusi pendapatan.
KEARIFAN LOKAL MASYARAKAT DALAM PENGELOLAAN HUTAN SANGIANG DESA SAGARAHIANG KECAMATAN DARMA KABUPATEN KUNINGAN JAWA BARAT
Authors: Herlina Nina , Syafrudin Oding , Setiana Aang 
Published: March 2024

Tujuan penelitian ini adalah untuk mengetahui bagaimana bentuk nilai-nilai kearifan lokal yang ada dan masih berjalan di mayarakat Desa Sagarahiang terkait dengan pengelolaan Hutan Sangiang?; Mengetahui bagaimana bentuk pengelolaan Hutan Sangiang berdasarkan adat atau kearifan lokal masyarakat DesaSagarahiang Kecamatan Darma Kabupaten Kuningan?; dan mengetahui persepsi masyarakat terhadap nilai dan norma kearifan lokal dalam pengelolaan Hutan Sangiang Desa Sagarahiang Kecamatan Darma Kabupaten Kuningan.Penelitian dilakukan di Desa Sagarahiang Kecamatan Darma Kabupaten Kuningan Provinsi Jawa Barat pada bulan Maret – April 2015. Penelitian ini dilakukan di masyarakat dan objek yang akan diteliti yaitu, dimensi/bentuk sosial budaya dan persepsi masyarakat terhadap nilai-nilai kearifan lokal dalam pengelolaan dan pelestarian Hutan Sangiang. Metode pengumpulan data dilakukan melalui survai lapangan dengan menyebarkan kuisioner melalui sampel yaitu metode purposive sampling, dilanjut ke snowball sampling, dengan menggunakan teknik wawancara dan penyebaran kuisioner. Sedangkan analisis data dilakukan dengan metode deskriptif kualitatif.Hasil Penelitian menunjukkan Rata-rata setiap responden mengetaui tentang kearifan lokal yang ada di Desa Sagarahiang, nilai penting kearifan lokal di Desa Sagarahiang, pengaruh kearifan lokal terkait dengan pengelolaan Hutan Sangiang, adanya acara adat dan pelaksanaanya. Namun rata-rata stiap responden kurang mengetahui tentang adanya hukum adat yang berlaku di Desa Sagarahiang.Kata Kunci : Kerifan lokal, sanksi adat, Hutan Sangiang
Identifikasi Jenis Dan Pemanfaatan Bambu Di Hutan Gunung Tilu Blok Banjaran Kabupaten Kuningan
Authors: Nurkholis Nurkholis , Herlina Nina , Nurlaila Ai 
Published: March 2024

Abstrak. Masyarakat di Desa Jabranti Blok Banjaran hanya memanfaatkan bambu sebagai bahan dasar kerajinan keranjang dan tepas. Bambu dapat dimanfaatkan sebagai bahan bangunan, bahan berkhasiat obat, bahan konsumsi, bahan kerajinan, bahan alat musik. Penelitian ini dilaksanakan di kawasan Hutan Gunung Tilu blok Banjaran Kecamatan Karangkancana Kabupaten Kuningan. Penelitian bertujuan untuk mengetahui jenis bambu dan morfologi jenis bambu dan mengetahui manfaat dari setiap bambu yg ditemukan. Metode yang digunakan adalah metode jelajah yaitu dengan cara menjelajahi objek penelitian. Ketika ditemukan rumpun bambu, maka dibuat petak ukur, kemudian dicatat, jenis bambu dan pohon yang terdapat di sekelilingnya. Jenis bambu yang ditemukan di Hutan Gunung Tilu Blok Banjaran sebanyak 5 genus, yaitu 4 bambu Gigantochloa, 3 bambu Bambusa, dua bambu Schizostachyum dan satu bambu Dendrocalamus. Manfaat dari beberapa jenis bambu tersebut adalah untuk bahan banguan,kerajinan tangan, obat, bahan konsumsi, alat musik, dan bahan bangunan.Kata Kunci: Identifikasi jenis bambu, pemanfaatan bambu.
Spesolimab Use for Generalized Pustular Psoriasis Flare Prevention in Patients with Concomitant Plaque Psoriasis: Results from the Effisayil 2 Trial
Authors: Merola Joseph , Anadkat Milan , Bhatia Neal , Bhutani Tina , Ferris Laura , Mostaghimi Arash , Guercio .Jason , Thoma Christian , Tang Ming , Lebwohl Mark 
Published: March 2024

Introduction & Objectives: Generalized pustular psoriasis (GPP) is a chronic inflammatory, potentially life-threatening skin disease, characterized by flares of sterile pustules. Spesolimab, an anti-interleukin-36 receptor monoclonal antibody, is approved to treat GPP flares in adults. Effisayil 2 (NCT04399837) evaluated the efficacy and safety of subcutaneous spesolimab in preventing GPP flares. Here, we report the effect of spesolimab versus placebo on Target Plaque Severity Score (TPSS) in patients with concomitant plaque psoriasis (PsO) in Effisayil 2.
Materials & Methods: Eligible patients with a history of GPP were randomized (1:1:1:1) to high-dose spesolimab (loading dose 600 mg, maintenance dose 300 mg every 4 weeks), medium-dose spesolimab (loading: 600 mg, maintenance: 300 mg every 12 weeks), low-dose spesolimab (loading: 300 mg, maintenance: 150 mg every 12 weeks), or placebo for 48 weeks. One PsO lesion of ≥9 cm2 with TPSS total score ≥5 and induration sub-score ≥2 was selected by the investigator at baseline for each participant. Severity of erythema, scaling, and induration (plaque thickness) of the target lesion was assessed at baseline and subsequent visits on a 5-point scale (0, none to 4, very marked), with the summation of the 3 subscores representing the TPSS total score (0-12).
Results: TPSS was measured in the 33/123 (27%) patients with PsO in the trial (9 placebo, 10 low-dose, 7 medium-dose, 7 high-dose). Mean TPSS total score was 4.2 in placebo and 4.6 in spesolimab-treated patients at baseline. By Week 4, mean TPSS remained similar in both groups (placebo, 4.3; spesolimab, 4.6). By Week 16, mean TPSS in the placebo group increased to 4.4 and decreased to 3.6 in spesolimab-treated patients. Mean TPSS total scores at Week 48 for both groups were below baseline (placebo, 3.3; spesolimab, 3.8). The number of patients with TPSS data declined in both groups over time due to GPP flare and/or early discontinuation.
Conclusion: Low baseline TPSS scores observed in this subpopulation of 33 GPP patients with concomitant PsO suggest that concomitant PsO plaque characteristics in GPP are generally mild to moderate. TPSS scores remained low and consistent throughout the trial in both dosing groups and decreases in TPSS score by Week 16 (spesolimab-treated) and Week 48 (both groups) compared to baseline were observed.
Bimekizumab Efficacy through Year 1 in Patients with Moderate to Severe Plaque Psoriasis Who Had Not Achieved a PASI 90 Response by Week 16: A Pooled Analysis from Four Phase 3/3B Trials
Authors: Han George , Gottlieb Alice , Armstrong April , Strober Bruce , Soung Jennifer , Herr Heather , Davis Leah , Lebwohl Mark 
Published: March 2024

Introduction: Psoriasis Area and Severity Index (PASI) is a commonly used tool for evaluating skin clearance; patients with ≥90% reduction from baseline PASI (PASI 90) have a level of skin clearance that has been associated with improved quality of life.1 Bimekizumab (BKZ) is a monoclonal IgG1 antibody that selectively inhibits interleukin (IL)-17F in addition to IL-17A.2 High PASI 90 response rates have been observed with BKZ, maintained through three years, across four phase 3/3b trials and an open-label extension (OLE).3–7 Here, we evaluate PASI response through Year 1 in patients who had not had a PASI 90 response during at least one visit up to and including Week 16, in four phase 3/3b trials of BKZ in moderate to severe plaque psoriasis.
Methods: Data were pooled from the double-blinded 52-week BE VIVID,3 56-week BE READY,4 56-week BE SURE,5 phase 3 trials, and the 48-week double-blind period of the BE RADIANT6 phase 3b trial. Included patients were randomized to BKZ 320 mg every 4 weeks (Q4W) to Week 16 and then received either BKZ 320 mg Q4W or Q8W maintenance dosing until end of Year 1 (Week 52 for BE VIVID; Week 48 for other trials). Results are reported as observed case (OC).
Results: Of the 1,362 patients randomized to BKZ across four phase 3/3b trials, 92.6% (n=1,261) had a PASI 90 response during at least one visit up to and including Week 16 while 7.1% (n=97) had not. PASI response was unavailable for 4 patients. The median (minimum, maximum) percent change from baseline PASI among the 97 patients without a PASI 90 response by Week 16 was −77.3 (−89.7, +20.0) at Week 16 (n=78) and −92.9 (−100, +90.7) at Year 1 (n=51).
Overall, 61.9% (60/97) of patients without a PASI 90 response by Week 16 completed their respective phase 3/3b trials and entered an OLE. By Year 1, 55.0% (33/60) achieved PASI 90 during at least one visit.
Conclusion: While the vast majority (92.6%) of patients treated with BKZ had a PASI 90 response during at least one visit up to Week 16, a large proportion of patients without a PASI 90 response by Week 16 who completed the phase 3/3b trials and entered an OLE had a PASI 90 response during at least one visit up to Year 1 (55.0%).
Diagnostic Discordance Among Histopathological Reviewers for Difficult-to-Diagnose Melanocytic Lesions
Authors: Hosler Gregory , Goldberg Matthew , Estrada Sarah , O'Neil Brendan , Amin Sapna , Plaza Jose 
Published: March 2024

Purpose: Histopathological examination is adequate for most melanocytic neoplasms. However, there is a subset of lesions with uncertain malignant potential that are difficult-to-diagnose where utilization of ancillary tests may be considered to aid in providing a more definitive diagnosis.
Study design: Under an IRB-approved protocol, 3,317 melanocytic lesions underwent independent diagnostic review by up to 9 unique board-certified dermatopathologists. Each lesion received ≥ 3 diagnoses via electronic whole slide images with zoom-in capability as benign, malignant, or unknown malignant potential (UMP). Lesions were subsequently binned according to the results of dermatopathology review in the following manner: concordant (all diagnoses of the same designation); conflicting (both benign and malignant designations); majority (a single designation with the highest number of diagnoses); and equivocal (equal number of different designations). Here we describe the identification of lesions suitable for ancillary testing.
Results: 30% of lesions were concordant benign and 46.3% were concordant malignant, indicating 76.3% of all lesions were not difficult-to-diagnose. 23.7% of lesions had some level of diagnostic difficulty and/or ambiguity defined by disagreement between reviewers and would be suitable for ancillary testing. Within these ~24%, 7.3% of lesions were majority benign, 4.8% of lesions were majority malignant, 2.7% were majority UMP, 6.9% of lesions were conflicting, and 1.6% of lesions were equivocal.

Conclusions: We demonstrate that in a large cohort of suspicious pigmented lesions, ~24% were difficult-to-diagnose, supporting the need for additional objective diagnostic tools. Patient care would benefit from ancillary testing to aid the diagnosing pathologist in identification of the most appropriate diagnosis to optimize patient management.
Potential conflicts of interest: This study was supported by Castle Biosciences, Inc. GAH and JAP have served as consultants for Castle Biosciences, Inc. MSG is an employee shareholder of Castle Biosciences, Inc. SIE is a consultant and shareholder for Castle Biosciences, Inc. Editorial assistance was provided by Brooke H. Russell, PhD, and Jason H Rogers, MSc, both employee shareholders of Castle Biosciences, Inc.
A New Peptide Skin-Brightening Facial Cream Demonstrated Clinical Improvement in Jawline Sagging, Discoloration and Overall Photodamage
Authors: Edison Brenda , Feng Li , Singh Surabhi , Guerrero Ritamarie , Parsa Ramine , Patel Ruchi , Dufort Marisa , Green Barbara 
Published: March 2024

Besides fine lines and wrinkles, chronological aging leads to discoloration, age spots, and more importantly, sagging and loss of elasticity on facial skin. There are ample consumer needs to reduce age spots and skin sagging with an increasing desire for effective topical solutions that can provide meaningful benefits in these areas. A new microdipeptide (acetyl dipeptide) technology was developed that demonstrated the potential to reduce skin inflammation and stimulate the skin’s supporting matrix. This clinical study was designed to test the effectiveness of a facial cream with a unique blend of microdipeptide technology along with brightening and firming ingredients to reduce the key signs of facial aging with twice daily use. The 16-week study included 43 healthy female subjects, ages 40-70 with diverse skin tones, and having mild to moderate jawline sagging with fine lines and/or hyperpigmentation by expert visual grading (3 to 6 on a 0 to 9 scale). Visual grading exhibited statistically significant reduction in all targeted skin aging signs starting at week 8, and continuing improvement to week 16, including jawline sagging (19%), laxity (19%), lift/ firmness (15%), as well as improved evenness of skin tone (16%), hyperpigmentation (14%) and overall photodamage (23%) (mean percent change, p< 0.05). Consumer perception questionnaires also revealed improvement after 16 weeks of use with tighter/tauter jawlines (88%), increased firmness (93%), skin elasticity (93%), refined facial contour (88%), less sagging (95%), and more lifted (91%) and volumized appearance (98%). Furthermore, subjects also indicated brighter skin (95%), increased radiance (93%), less discoloration (86%), fading dark spots (77%), reduced fine lines (93%) and wrinkles (95%), skin looks younger (95%), and overall less noticeable aging signs (95%). Clinical photography supported both the clinical grading and consumer perception of benefits. In addition, these clinical outcomes are further supported by in vitro and ex vivo investigations showing the microdipeptide activity on inhibiting the expression of inflammatory cytokines and inducing multiple matrix building biomarkers, beyond elastin, pro-collagen and hyaluronic acid to include decorin and fibronectin. Gene expression profiling showed changes associated with skin barrier and extracellular matrix organizations, therefore mimicking a younger-looking skin. These results demonstrated that this peptide facial cream was well-tolerated and effective in improving jawline sagging, facial skin firmness, skin brightening, and reducing the overall signs of aging.
VP-102 Tolerability Evaluated by Concomitant Analgesic Medication Usage in Two Phase 3 Trials for Molluscum Contagiosum
Authors: Siegfried Elaine , Eichenfield Lawrence , Kwong Pearl , Sugarman Jeffrey , Cutler Susan , Goldenberg Gary 
Published: March 2024

Background: Drug tolerability is the degree to which a patient can tolerate a drug's adverse effects. VP-102, a drug-device combination product containing cantharidin (0.7%), a vesicant, is approved for treatment of molluscum contagiosum (molluscum) in patients >2. Local skin reactions (LSRs) are expected, including pain. In Phase 3 trials, 97% of LSRs were mild to moderate. The discontinuation rate due to an adverse reaction was 2.3%:0.5% (drug:vehicle) treated subjects, respectively. This post-hoc analysis evaluated VP-102 tolerability based on analgesic usage over the study course.
Methods: VP-102 or vehicle was applied to all baseline and new lesions once every 21 days until complete clearance, or up to a maximum of 4 applications. Acetaminophen or ibuprofen were permitted for application site pain and/or other Adverse Reactions.
Results: Overall incidence of pain at any time for a VP-102 subject was 62.7% (195/311), with the majority [(60.5%),188/311] as mild to moderate. 18.6% (58/311) of VP-102 and 1.4% (3/216) of vehicle treated subjects received an analgesic, including 15.8% (49/311) for an LSR after the first VP-102 application.

Median VP-102 analgesic use for LSR pain (range) was 2 (1-14) days for the entire study, and 2 (1-9) days after the first application. 29% of participants who reported analgesic usage took medication ≤1 day. Analgesic usage for AEs other than LSR pain (≥ 5% of participants) included 6% (19/311) for application site vesicles. There were no treatment-related SAEs reported.

Conclusions: In this largely pediatric population, VP-102 was well-tolerated, with a short duration of elective analgesic use.