bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of Ischaemic Heart Disease with Hospitalized Ischaemic Stroke Patients in a Tertiary Care Hospital
Authors: Kabir Nazmul , Ahmed KM Ahsan , Sarker Md Sadekur Rahman , Chowdhury Md Tauhidul Islam 
Published: April 2024

Background: Stroke and IHD is a major health problem all over the world. But few studies have been done in our country to see the association of IHD among ischaemic stroke patients. Objective: The purpose of the present study was to evaluate the prevalence of IHD among hospitalized ischaemic stroke patients and to identify their common risk factors. Methodology: This was a cross-sectional study carried out in 50 ischaemic stroke patients admitted in Medicine Wards of Khulna Medical College Hospital, from July 2012 to December 2012. The patients were taken in both sexes having more than 18 years age and CT-scan evidence of ischaemic stroke by purposive sampling technique. After recruitment of patients IHD was established by ECG findings. Subsequently other risk factors were identified and were recorded. Results: The incidence of stroke for individuals older than 80 years was approximately 30.0% compared with 8.0% for individuals between 31 to 40 years of age. Among them IHD was more common in 51 to 60 years old stroke patients (33.33%) but less common in older than 80 years of age (8.33%). All of those having both ischaemic stroke and IHD were hypertensive. Among them 58.33% cases had severe hypertension but those having only stroke but no IHD 73.68% cases were hypertensive. Among them 34.21% had severe hypertension. Regarding lipid profile those having both ischaemic stroke and IHD 83.33% were dyslipidaemic but of those having only stroke but no IHD 52.63% were dyslipidaemic. This study revealed 41.67% diabetic patients developed both Ischaemic stroke and IHD compared to 31.58% diabetic patients developed only ischaemic stroke. Conclusion: In conclusion IHD and ischaemic stroke patients share similar pathophysiological mechanisms and, consequently, many risk factors.
Journal of National Institute of Neurosciences Bangladesh, July 2023; 9(2):98-102
Clinical Characteristics, Laboratory Findings and Functional Outcomes of Guillain-Barre Syndrome: Experience of 50 Cases in Bangladesh
Authors: Islam Md Rashedul , Rahman Tanbin , Habib Rumana , Rahman Aminur , Bhowmik Nirmalendu Bikash , Haque Md Amirul 
Published: April 2024

Background: Guillain-Barré Syndrome (GBS) is an acute immune-mediated polyradiculoneuropathy which is one of the most frequent causes of acute flaccid paralysis. GBS has diverse clinical phenotype and functional outcome.
Objective: The purpose of the present study was to evaluate clinical profiles and outcomes of GBS patients admitted in a tertiary care centre of Bangladesh.
Methodology: This prospective cohort study was conducted in the Department of Neurology from January 2016 to June, 2020 in BIRDEM General Hospital, Dhaka, Bangladesh. Adult patients more than or equal to 18 years of age who had fulfilled the diagnostic criteria of GBS were included in the study.
Results: Majority of the patients were male (64.0%). The most common presenting symptom at entry was ascending paralysis that occurred in 24 patients (48.0%). Mean age of the study population is 31.5 years ranging from 19 to 60 years. Twenty four (48.0%) patients had GBS disability score of 4 at entry. On the contrary, 39(78.0%) cases had GBS disability score of 4 at nadir. Diarrhea was reported in 14(28.0%) cases and respiratory tract infection was reported in 9(18.0%) cases. Fifty six percents of patients had GBS disability score of 0 to 2, 38.0% had 3 to 4 and only 6.0% had 5 to 6. Majority of the patients had Brighton criteria level 1 certainty of diagnosis (62.0%) in this study. GBS variants according to nerve conduction studies were AIDP (54.0%), AMAN (34.0% and AMSAN (12.0%). CSF protein was raised in 72.0% cases. Patients diagnosed with AMAN and AMSAN had worse outcome after 3 months in comparison to AIDP group of patients if we consider GBS disability score.
Conclusion: GBS has been found more in younger and male population group in this present study where Antecedent events were not found in majority of the patients. AIDP was the commonest variant in our study with comparatively good outcome followed by AMAN.
Journal of National Institute of Neurosciences Bangladesh, July 2023;9(2):108-115
Behavior of Non-Hybrid and Hybrid Forms of Fibro-Osseous Lesions in the Cranio-Maxillofacial Region of Patients Attending at the Tertiary Care Hospital in Dhaka City of Bangladesh
Authors: Shahed Abu Mohammad , Ahmed Mohiuddin , Molla Motiur Rahman , Huq Md Rezaul , Begum Bilquis Ara 
Published: April 2024

Background: Fibro-osseous lesions of the craniofacial complex are represented by a variety of disease processes that are characterized by the nature of ossifications and calcifications.
Objective: The purpose of the present study was to see the behavior of non-hybrid and hybrid forms of fibro-osseous lesions.
Methodology: This was a cross-sectional study at the Department of Oral & Maxillofacial Surgery of Dhaka Dental College & Hospital, Dhaka (DDCH), Shaheed Suhrawardy Hospital, Dhaka (SSH) and Bangabandhu Sheikh Mujib Medical University (BSMMU) from January 2004 to December 2005. Participants were selected for the study who attended into outpatient and inpatient departments with fibro-osseous lesions during study period, irrespective of age & sex. patients were included who gave informed consent, patients attended with jaw swellings, and radiologically suspecting as fibro-osseous lesions, Biopsy proven fibro-osseous lesions. All patients were advised initially for radiological examination which includes orthopantomogram (OPG), postero-anterior (P/A) view of skull with mandible, lateral view of skull with mandible. After taking informed consent, biopsy was done. The diagnosis was established initially in all cases preoperatively on the basis of an incision biopsy. Postoperatively every surgical specimen was examined carefully and sectioned to examine the nature of tissue within the tumour and examination of the expansion and perforation of the bone was performed. Then histologic examination was done for re-evaluation.
Result: A total number of 40 patients were included, in Hybrid form, the growth pattern of majority of swellings were slow at first but later rapid (66.7%) while in Non-hybrid form, it was slow always (61.8%). Maximum site of involvement was in mandible (66.7%) in Hybrid form whereas both mandible and maxilla were equally involved in Non-hybrid form. Hybrid form has significantly higher probability of tenderness in comparison with Non-hybrid form (p <0.001). Tenderness was found in all cases of hybrid form (100%) whereas in Non-hybrid form it was 17.6%. Most of size of Non-hybrid swellings were less than 35 sq. cm but for Hybrid form the size were comparatively bigger. In Non-hybrid form, only 2.9%% of swellings were hard and egg shell crackling but it was 33.3% for Hybrid form and the difference was significant. Recurrent bleeding from the swellings was noted in few cases of hybrid form (33.3%) but it was noted in minority of non-hybrid form (5.9%).
Conclusion: In conclusion the behavior of non-hybrid and hybrid forms of fibro-osseous lesions is varied from each other.
Journal of National Institute of Neurosciences Bangladesh, July 2023;9(2):136-140
A Rare Case Report of Acrania
Authors: Arman DM , Mukherjee Sudipta Kumer , Islam Joynul 
Published: April 2024

Acrania is a rare congenital anomaly and characterized by partial or complete absence of the calvarium. Although acrania associated with anencephaly is a well-recognized entity but isolated acrania is a rare anomaly. Ultrasound allows early diagnosis of this anomaly. The fetus was found to have a completely formed brain, base of the skull and facial structures but lacking a cranium. Authors present a rare case of acrania.
Journal of National Institute of Neurosciences Bangladesh, July 2023;9(2):157-160
Describing undergraduate students’ reasoning and use of evidence during argumentation about socioscientific issues systems
Authors: Jimenez P. Citlally , Alred Ashley R. , Dauer Jenny M. 
Published: April 2024

IntroductionWe conducted research in a post-secondary, large-enrollment science literacy course that asks students to apply multidisciplinary scientific evidence when providing an argument about the potential social and ecological consequences of policy solutions to socioscientific issues (SSI).MethodsCoding schemes were developed to describe students’ levels of proficiency in constructing arguments about the nature of SSI systems and were created through inductive coding of student arguments about SSI systems embedded within a structured decision-making process.ResultsThe coding schemes included student practices in 1) providing reasoning about the potential consequences of multiple solutions for an SSI, 2) linking evidence to reasoning, and 3) sources of evidence. In the highest level in the reasoning coding scheme, students used clear and traceable scientific evidence to address an assumption by specifying how (a mechanism) or by how much, an SSI solution might satisfy a desired policy objective.DiscussionThe resulting framework describes how students apply multidisciplinary scientific evidence to support their SSI reasoning, which may aid researchers and educators in exploring how students interpret and integrate scientific evidence in an SSI-context, with the ultimate goal of bolstering students’ ability to reason about evidence outside the classroom.
Integration of electric vehicle into smart grid: a meta heuristic algorithm for energy management between V2G and G2V
Authors: Srihari G. , Krishnam Naidu R. S. R. , Falkowski-Gilski Przemysław , Bidare Divakarachari Parameshachari , Kiran Varma Penmatsa Ravi 
Published: April 2024

Recently, Electric Vehicles (EV) have been providing fast response and substantial progress in the power generation model. Further, EVs are exploited as adaptable Energy Storage Systems (ESSs) and show a promising performance in ancillary service markets to increase the demand of Smart Grid (SG) integration. The expansion of Vehicle-to-Grid concept has created an extra power source when renewable energy sources are not available. Yet, numerous operational problems still are required to be considered for EV implementation to turn out to be extensive. Even the development of Photo-Voltaic (PV) technology creates a problem in SGs when used for EV charging. Because of this, the Energy Management System (EMS) is required to handle charging requirements and deal with the intermittent generation. Here, in this research, an Improved Honey Badger algorithm (IHBA) is proposed for integrating SGs with EV parking lot, solar panels, and dynamic loads at the Point of Common Coupling (PCC). The proposed IHBA uses a dynamic programming method to optimize the charging Grid-to-Vehicle (G2V) or discharging Vehicle-to-Grid (V2G) profiles of the EVs using the forecasts of PV generation. This algorithm considers user preferences while also lowering reliance on the grid and maximizing SG effectiveness. The study’s findings show that the Honey Badger method is efficient in resolving issues involving large search spaces. The developed method is used to optimize charging and discharging of EV which is tested in MATLAB to obtain a stable load profile. From the evaluation of obtained results, it is evident that the IHBA controller outperforms the WOA and EHO controllers in terms of total harmonic distortion voltage (3.12%), power loss (0.197 kW) and efficiency (98.47%).
A preliminary study of optimal treatment response rates in patients undergoing hepatic arterial infusion chemotherapy combined with molecular targeting and immunotherapy
Authors: Li Mei , Liao Jun , Wang Li , Lv Tianye , Sun Qianfu , Xu Yan , Guo Zhi , Quan Manman , Qin Hao , Yu Haoyang , Zhang Kai , Xing Wenge , Yu Haipeng 
Published: April 2024

ObjectivesThis study aimed to examine the effectiveness of the best response rate (BRR) as a surrogate for overall survival (OS), using the modified Response Evaluation Criteria in Solid Tumors (mRECIST), in patients with unresectable hepatocellular carcinoma (HCC) undergoing hepatic arterial infusion chemotherapy (HAIC) with fluorouracil, leucovorin, and oxaliplatin (FOLFOX) combined with molecular targeting and immunotherapy.MethodsThis study enrolled 111 consecutive patients who had complete imaging data. The median age of patients was 58 years (IQR 50.5-65.0). Among the patients, those with Barcelona Clinic Liver Cancer (BCLC) stage A, BCLC stage B, and BCLC stage C comprised 6.4%, 19.1%, and 73.6%, respectively. The optimal threshold of BRR can be determined using restricted cubic splines (RCS) and the rank sum statistics of maximum selection. Survival curves of patients in the high rating and low rating groups were plotted. We then used the change-in-estimate (CIE) method to filter out confounders and the inverse probability of treatment weighting (IPTW) to balance confounders between the two groups to assess the robustness of the results.ResultsThe median frequency of the combination treatment regimens administered in the overall population was 3 times (IQR 2.0-3.0). The optimal BRR truncation value calculated was −0.2. Based on this value, 77 patients were categorized as the low rating group and 34 as the high rating group. The differences in the OS between the high and low rating groups were statistically significant (7 months [95%CI 6.0-14.0] vs. 30 months [95%CI 30.0-]; p&lt; 0.001). Using the absolute 10% cut-off value, the CIE method was used to screen out the following confounding factors affecting prognosis: successful conversion surgery, baseline tumor size, BCLC stage, serum total bilirubin level, number of interventional treatments, alpha-fetoprotein level, presence of inferior vena cava tumor thrombus, and partial thrombin activation time. The survival curve was then plotted again using IPTW for confounding factors, and it was found that the low rating group continued to have better OS than the high rating group. Finally, the relationship between BRR and baseline factors was analyzed, and inferior vena cava tumor thrombus and baseline tumor size correlated significantly with BRR.ConclusionsBRR can be used as a surrogate endpoint for OS in unresectable HCC patients undergoing FOLFOX-HAIC in combination with molecular targeting and immunotherapy. Thus, by calculating the BRR, the prognosis of HCC patients after combination therapy can be predicted. Inferior vena cava tumor thrombus and baseline tumor size were closely associated with the BRR.
A low-glucose eating pattern is associated with improvements in glycemic variability among women at risk for postmenopausal breast cancer: an exploratory analysis
Authors: Jospe Michelle R. , Liao Yue , Giles Erin D. , Hudson Barry I. , Slingerland Joyce M. , Schembre Susan M. 
Published: April 2024

BackgroundHigh glycemic variability (GV) is a biomarker of cancer risk, even in the absence of diabetes. The emerging concept of chrononutrition suggests that modifying meal timing can favorably impact metabolic risk factors linked to diet-related chronic disease, including breast cancer. Here, we examined the potential of eating when glucose levels are near personalized fasting thresholds (low-glucose eating, LGE), a novel form of timed-eating, to reduce GV in women without diabetes, who are at risk for postmenopausal breast cancer.MethodsIn this exploratory analysis of our 16-week weight loss randomized controlled trial, we included 17 non-Hispanic, white, postmenopausal women (average age = 60.7 ± 5.8 years, BMI = 34.5 ± 6.1 kg/m2, HbA1c = 5.7 ± 0.3%). Participants were those who, as part of the parent study, provided 3–7 days of blinded, continuous glucose monitoring data and image-assisted, timestamped food records at weeks 0 and 16. Pearson’s correlation and multivariate regression were used to assess associations between LGE and GV, controlling for concurrent weight changes.ResultsIncreases in LGE were associated with multiple unfavorable measures of GV including reductions in CGM glucose mean, CONGA, LI, J-Index, HBGI, ADDR, and time spent in a severe GV pattern (r = −0.81 to −0.49; ps &lt; 0.044) and with increases in favorable measures of GV including M-value and LBGI (r = 0.59, 0.62; ps &lt; 0.013). These associations remained significant after adjusting for weight changes.ConclusionLow-glucose eating is associated with improvements in glycemic variability, independent of concurrent weight reductions, suggesting it may be beneficial for GV-related disease prevention. Further research in a larger, more diverse sample with poor metabolic health is warranted.Clinical trial registration: ClinicalTrials.gov, NCT03546972.
The fly route of extended-spectrum-β-lactamase-producing Enterobacteriaceae dissemination in a cattle farm: from the ecosystem to the molecular scale
Authors: Caderhoussin Alann , Couvin David , Gruel Gaëlle , Quétel Isaure , Pot Matthieu , Arquet Rémy , Dereeper Alexis , Bambou Jean-Christophe , Talarmin Antoine , Ferdinand Séverine 
Published: April 2024

IntroductionThis study aimed to understand the origin and to explain the maintenance of extended-spectrum β-lactamase (ESBL) Enterobacteriaceae isolated from food-producing animals in a third-generation cephalosporin (3GC)-free farm.MethodsCulture and molecular approaches were used to test molecules other than 3GC such as antibiotics (tetracycline and oxytetracycline), antiparasitics (ivermectin, flumethrin, fenbendazol, and amitraz), heavy metal [arsenic, HNO3, aluminum, HNO3, cadmium (CdSO4), zinc (ZnCl2), copper (CuSO4), iron (FeCl3), and aluminum (Al2SO4)], and antioxidant (butylated hydroxytoluene) as sources of selective pressure. Whole-genome sequencing using short read (Illumina™) and long read (Nanopore™) technologies was performed on 34 genomes. In silico gene screening and comparative analyses were used to characterize the genetic determinants of resistance, their mobility, and the genomic relatedness among isolates.ResultsOur analysis unveiled a low diversity among the animal ESBL-producing strains. Notably, E. coli ST3268 was recurrently isolated from both flies (n = 9) and cattle (n = 5). These E. coli ST3268/blaCTX-M-15/blaTEM-1B have accumulated multiple plasmids and genes, thereby representing a reservoir of resistance and virulence factors. Our findings suggest that flies could act as effective mechanical vectors for antimicrobial gene transfer and are capable of transporting resistant bacteria across different environments and to multiple hosts, facilitating the spread of pathogenic traits. A significantly higher mean minimum inhibitory concentration of oxytetracycline (841.4 ± 323.5 mg/L vs. 36.0 ± 52.6 mg/L, p = 0.0022) in ESBL E. coli than in non-ESBL E. coli and blaCTX-M-15 gene overexpression in oxytetracycline-treated vs. untreated ESBL E. coli (RQOxy = 3.593, p = 0.024) confirmed oxytetracycline as a source of selective pressure in ESBL E. coli.DiscussionThe occurrence of ESBL E. coli in a farm without 3GC use is probably due to an as yet undefined human origin of Enterobacteriaceae blaCTX-M-15 gene transmission to animals in close contact with cattle farm workers and the maintenance of the local ESBL E. coli reservoir by a high fly diversity and oxytetracycline selective pressure. These findings highlight the critical need for stringent vector control to mitigate antimicrobial resistance spread for preserving public health. Addressing this issue necessitates a multifaceted approach combining microbial genetics, vector ecology, and farm management practices.
Integrative analysis of proteomics and lipidomic profiles reveal the fat deposition and meat quality in Duroc × Guangdong small spotted pig
Authors: Wu Zhuosui , Wang Zhonggang , Wang Pan , Cheng Leiyan , Li Jianhao , Luo Yanfeng , Yang Linfang , Li Linfeng , Zeng Jianhua , Hu Bin 
Published: April 2024

IntroductionThis study aims to explore the important factors affecting the characteristics of different parts of pork.MethodsLipidomics and proteomics methods were used to analyze DAL (differential lipids) and DAPs (differential proteins) in five different parts (longissimus dorsi, belly meat, loin, forelegs and buttocks) of Duhua pig (Duroc × Guangdong small spotted pig), to identify potential pathways affecting meat quality, investigating fat deposition in pork and its lipid-protein interactions.ResultsThe results show that TG (triglyceride) is the lipid subclass with the highest proportion in muscle, and the pathway with the most significantly enriched lipids is GP. DAP clustered on several GO terms closely related to lipid metabolism and lipogenesis (lipid binding, lipid metabolism, lipid transport, and lipid regulation). In KEGG analysis, there are two main DAP aggregation pathways related to lipid metabolism, namely Fatty acid degradation and oxidative phosphorylation. In PPI analysis, we screened out 31 core proteins, among which NDUFA6, NDUFA9 and ACO2 are the most critical.DiscussionPC (phosphatidylcholine) is regulated by SNX5, THBS1, ANXA7, TPP1, CAVIN2, and VDAC2 in the phospholipid binding pathway. TG is regulated by AUH/HADH/ACADM/ACADL/HADHA in the lipid oxidation and lipid modification pathways. Potential biomarkers are rich in SFA, MUFA and PUFA respectively, the amounts of SFA, MUFA and PUFA in the lipid measurement results are consistent with the up- and down-regulation of potential biomarker lipids. This study clarified the differences in protein and lipid compositions in different parts of Duhua pigs and provided data support for revealing the interactions between pork lipids and proteins. These findings provide contributions to the study of intramuscular fat deposition in pork from a genetic and nutritional perspective.