bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improvement of technology of operation of engineering systems of residential buildings based on the use of organizational and technological modeling
Authors: Afanasiev Georgij 
Published: March 2024

The author has proposed a model for the technical operation of residential buildings, which considers two main functions for maintaining the housing stock: scheduled preventive inspection and repair of technical facilities, as well as the elimination of sudden malfunctions of technical equipment, in particular emergency ones. It is believed that the work team can begin scheduled preventive maintenance and inspection only when all requests for sudden malfunctions have been satisfied.
To conduct the study, the theory of queuing is used - one of the probabilistic methods.
The main parameters of the model are: the average time between the occurrence of equipment malfunctions, the average time for eliminating such malfunctions, the average time for preventive inspection and repair of one technical object. Based on the methods of queuing theory, the characteristics of the system are determined that determine the quality of its work, as well as the boundaries of changes in parameters at which the system copes with the work from the standpoint of one or another criterion.
Method of processing uploaded reports in the form of a database by automated means
Authors: Zheleznov Maksim , Fedorov Sergey , Kazakov Sergey , Vasil'kova Ol'ga 
Published: March 2024

The purpose of the research presented in this article is to convert downloadable reports in the form of a database and flat tables into a consolidated report according to a given form.
The implementation of the assigned tasks was carried out using information modeling technology, in particular, the general data environment, the BIM module of the domestic platform for managing construction projects EXON and MS Excel tools. To generate the final report, the original database was transformed in two stages: obtaining initial data and primary processing, followed by obtaining an intermediate form of the database, then executing search queries and then generating a consolidated report.
As a result of the research, an algorithm for implementing the task was formed, principles for searching values by key string were formulated, the database was converted and the final form of the report was generated.
PENGARUH PENGGUNAAN Ipomoea aquatica (KANGKUNG) PADA SISTEM CRS (Close Resirculation System) BUDIDAYA IKAN LELE DENGAN TEKNOLOGI FITOREMEDIASI
Authors: Saad Moch , Purnamasari Ika , Prihatini Endah Sih , Mas'ud Faisol 
Published: March 2024

Akumulasi limbah tersebut dapat menyebabkan penurunan kualitas air yang berpengaruh terhadap proses fiiologis, tingkah laku, pertumbuhan, dan mortalitas ikan. Teknologi budidaya yang ramah lingkungan dan hemat air sangat dibutuhkan. Salah satu upaya pengelolaan untuk meningkatkan kualitas air dan mengoptimalkan pemanfaatan limbah air budidaya adalah dengan sistem fitoremediasi secara resirkulasi tertutup. Salah satu upaya pengelolaan untuk meningkatkan kualitas air dan mengoptimalkan pemanfaatan limbah air budidaya adalah menggunaan sistem fitoremediasi dengan resirkulasi tertutup. Tujuan penelitian ini adalah untuk mengetahui pengaruh penggunaan Ipomoea aquatica (kangkung) pada sistem CRS (close resirculation system) budidaya ikan lele dengan teknologi fitoremediasi teknologi yang efektif dan efisien. Metode penelitian yang digunakan adalah deskriptif kualitatif untuk menguji perbandingan antara budidaya lele tradisional, menggunakan sirkulasi serta menggunakan teknologi Ipomoea aquatica (kangkung) dengan sistem CRS (close resirculation system) budidaya ikan lele. Penelitian dilaksanakan pada bulan Mei hingga Juli 2021 di kelompok Pembudidaya Ikan â€œLestari Makmurâ€Â di Desa Sambangan, Kecamatan Babat, Kabupaten Lamongan, Propinsi Jawa Timur. Berdasarkan hasil uji coba teknologi fitoremediasi menggunakan kangkung dengan sistem CRS (closed resirculation system) yang dibandingkan dengan tanpa menggunakan metode tersebut menunjukkan bahwa teknologi fitoremediasi menggunakan kangkung dengan sistem CRS (closed resirculation system) memberikan hasil yang positif dan lebih baik dalam meningkatkan kualitas budidaya ikan lele. Ikan lele yang dipelihara menggunakan teknologi fitoremediasi memperlihatkan kualitas air yang relatif baik dibandingkan tanpa menggunakan teknologi fitoremediasi, pertambahan bobot juga terlihat menunjukkan pola peningkatan yang baik dengan tingkat kelulus hidupan yang lebih tinggi dengan rata-rata 97%.
Evaluasi Kawasan Konservasi Laut Dengan Pendekatan Pressure State Response
Authors: Haryani Eny Budi Sri 
Published: March 2024

Penelitian ini dilakukan di Kawasan Konservasi Laut (KKL) Raja Ampat, Provinsi Papua Barat, pada bulan Oktober 2019. Pada awal penetapan sebagai KKL tahun 2007, kondisi perairan Raja Ampat dipersepsikan baik, dengan keanekaragaman sumberdaya ikan (SDI) tinggi. Namun saat ini perlu dievaluasi, setelah 15 tahun sejak ditetapkan menjadi KKL. Tujuan penelitian ini untuk mengevaluasi kondisi KKL dengan pendekatan analisis PSR (pressure, state, response), dengan pengumpulan data primer dan sekunder. Data primer berupa persepsi masyarakat terhadap pengaruh adanya KKL terkait kondisi SDI, ekosistem dan sosial ekonomi masyarakat, dengan instrumen penelitian berupa kuesioner dan wawancara dengan purposive sampling terhadap responden, yaitu penangkap ikan, aktivis dan tokoh masyarakat, wisatawan dan penentu kebijakan setempat, menggunakan skala jawaban persentase (%). Data sekunder diperoleh dari dinas terkait berupa kondisi demografi, geografis dan sosial budaya. Hasil penelitian, di KKL Raja Ampat terdapat pressure (tekanan) berupa kesejahteraan masyarakat rendah, sumber mata pencaharian mengandalkan penangkapan ikan, aktivitas perikanan merusak dan illegal fishing dari nelayan pendatang, berkembangnya pariwisata bahari dan isu rencana penambangan di laut. State (kondisi eksisting) bahwa perairan belum rusak, jumlah kapal dan nelayan serta biaya melaut meningkat, harga ikan meningkat, kondisi terumbu karang dan mangrove lebih baik, dengan kesejahteraan meningkat dan KKL dianggap baik. Juga ketersediaan ikan semakin banyak, sehingga penangkapan ikan semakin mudah, walaupun area penangkapan ikan menjadi jauh, sehingga kesejahteraan masyarakat semakin baik. Response (tanggapan) dengan membuat regulasi pada skala desa atau kabupaten, yang fungsinya untuk menyelamatkan SDI, ekosistem pesisir dan kesejahteraan masyarakat.Â Data isian kuesioner, bila diklasifikasi dengan kisaran, persepsi baik kisaran 50-90 % responden, suatu kondisi yang baik, sedangkan persepsi buruk/jelek dengan kisaran 0-20% responden. Saran kebijakan, bahwa response yang ada agar segera diatur dalam peraturan daerah, dan segera dibuat strategi pengembangan KKL Raja Ampat berdasarkan analisis PSR ini yang dilengkapi bioeconomic analysis danÂ economic valuation, agar strategi pengembanganÂ KKL lebih realistis, dengan dasar analisis ilmiah yang valid.Â
EFEKTIVITAS PROBIOTIK TERHADAP EFISIENSI PAKAN DAN ULAS DARAH IKAN KOMET (Carassius auratus)
Authors: Suseno Dewi Nurmalita , Puspitasari Indah , Jayanti Shara 
Published: March 2024

Penelitian ini dilakukan untuk mengetahui potensi efektivitas pemberian probiotik kepada efisiensi pakan dan dalam darah ikan komet sebagai parameter kesehatan ikan. Dosis pakan yang dicampurkan dengan probiotik ialah yaitu (A0=kontrol; A1=50ml/kg; A2=100 ml/kg ml/kg; A3=200 ml/kg; A4=400 ml/kg) dilakukan selama Â± 1,5 bulan masa pemeliharaan. Hasil perhitungan FCR perlakuan A2 hasil analisa varian menggunakan kruskal wallis pada FCR ikan komet menunjukkan adanya perbedaan signifikan (P=0,012) antara ikan yang diberikan dosis probiotik yang berbeda , serta ikan mas komet mampu meningkatkan respon imunitas ikan terhadap antigen yang masuk dalam tubuh ikan,Â hal ini dibuktikan dengan peningkatan jumlah leukosit dan jumlah aktifitas fagositosis pada preparate ulas darahÂ
Prevención del suicidio. Una perspectiva salubrista. De lo individual a lo colectivo
Authors: Bimbela Pedrola José Luis 
Published: March 2024

El suicidio me cuestiona individual y colectivamente. Personal y profesionalmente. Emocional y éticamente. Física y socialmente. Y, desde luego, espiritualmente. Y me alegra muchísimo que desde la salud pública (a la que nada humano le es ajeno) ya se estén poniendo en marcha acciones de todo tipo dirigidas a lograr una prevención eficaz y sostenible en un tema que era tabú hasta hace muy poco tiempo.
De igual manera que hacer frente, en su momento, a la pandemia del VIH/SIDA con valentía y decisión permitió incorporar mejoras en la salud pública de España que se acabaron consolidando, como el papel activo de pacientes y familiares (tanto en las consultas individuales como en las intervenciones educativas a través de las escuelas de pacientes); si se afronta la cuestión del suicidio con coraje y determinación se podrá alumbrar una nueva sociedad. Mejor y más saludable. Ética, física, emocional, social y espiritualmente.
De todo ello trataré en ese artículo. Desde la teoría y desde la práctica. Con evidencias científicas y con experiencias vivenciales. Con dichos y con hechos. Con reflexión y con intuición. Con mucho amor y con algo de humor.
Isolation of novel <i>Actinomyces oris</i> and <i>Aggregatibacter actinomycetemcomitans</i> bacteriophages and study of their biological characteristics <i>in vitro</i>
Authors: Kochetova T. A. , Yuskevich V. V. , Zurabov F. M. , Sadykova G. T. , Medvedev P. V. , Popova V. M. 
Published: March 2024

SCIENTIFIC RELEVANCE. The incidence of periodontal infections with antibiotic-resistant strains of Actinomyces oris and Aggregatibacter actinomycetemcomitans capable of forming biofilms in the oral cavity is increasing, and the effectiveness of antimicrobials against biofilms is insufficient. Therefore, the isolation of bacteriophages active against A. oris and Ag. actinomycetemcomitans is an urgent task.AIM. This study aimed to isolate bacteriophages active against A. oris and Ag. actinomycetemcomitans, study their biological properties, and select optimum culture conditions providing pure lines and high titres of bacteriophages.MATERIALS AND METHODS. Bacteriophages were isolated from biosamples of saliva, dental plaque, and periodontal pocket contents. The study determined bacteriophage characteristics, including the optimum multiplicity of infection, phage–cell system cultivation time, resistance to various temperatures and pH, and storage stability. Bacteriophage morphology was studied using transmission electron microscopy. Negative colony morphology, lytic activity, host range, and specificity were assessed using spot testing and the Gratia method. Bacterial strains were obtained from the strain collection of the Micromir research and production centre.RESULTS. The authors isolated and studied 3 novel bacteriophages active against A. oris (vB_AorP_1/G-12, vB_AorP_2/Ch-28, and vB_AorP_3/Bl-35) and 1 bacteriophage active against Ag. actinomycetemcomitans (vB_AacS_1/Dc-1). The A. oris bacteriophages were classified as podoviruses, and the vB_AacS_1/Dc-1 bacteriophage was classified as a siphovirus. The phages formed completely transparent round plaques without a halo, with a diameter ranging from 0.8±0.1 to 4.0±0.2 mm. The optimum parameters established to obtain pure phages with maximum titres included a multiplicity of infection of 0,1–10 and phage–cell system cultivation time of 8–12 hours. The study demonstrated the ability of A. oris bacteriophages to lyse Actinomyces naeslundii strains. Of the 15 A. oris bacteriophage strains studied, vB_AorP_1/G-12, vB_AorP_2/Ch-28, and vB_AorP_3/Bl-35 lysed 10, 8, and 12 bacterial strains, respectively. The vB_AacS_1/Dc-1 phage isolate exhibited lytic activity against both tested strains of Ag. actinomycetemcomitans. The studied phages demonstrated stability under abiotic stress and long-term storage conditions.CONCLUSIONS. The authors isolated 3 novel bacteriophages active against A. oris and 1 bacteriophage active against Ag. actinomycetemcomitans and studied their biological properties. The isolated bacteriophages are promising as candidates for further research using clinical strains and whole-genome sequencing.
Certification of a pharmacopoeial reference standard for potency testing of recombinant interferon α-2b
Authors: Gaiderova L. A. , Lebedeva Yu. N. , Lobanova T. N. , Lipatova E. K. , Volkova R. A. , Fadeikina O. V. 
Published: March 2024

SCIENTIFIC RELEVANCE. Potency testing of recombinant interferons requires a reference standard. The availability of International Standards (ISs) that are commonly used to assess the quality of recombinant interferons is currently limited. Therefore, the quality of interferons should be assessed using pharmacopoeial reference standards (RSs) certified using ISs (if available).AIM. This study aimed to certify a pharmacopoeial RS for potency testing of recombinant interferon α-2b.MATERIALS AND METHODS. The potency determination involved comparing the inhibition of the virus-induced cytopathic effect observed in cell culture with the candidate RS and the WHO International Standard for Human rDNA-derived interferon α-2b. The study used A-549 and MDBK cell lines with encephalomyocarditis (EMC) and vesicular stomatitis (VSV) viruses. The authors followed the requirements of the State Pharmacopoeia of the Russian Federation (Cell-Culture Bioassays for Interferon Products, OFS.1.7.2.0002.15). The results were recorded using instrumental and visual methods. The calculations used mathematical statistics. To factor in the influence of intermediate precision, the authors applied Student’s t-test.RESULTS. The authors developed a certification programme and procedure and certified the pharmacopoeial RS for recombinant human interferon α-2b (rhIFN α-2b) to identify the corresponding medicinal products (by virus neutralisation) and test their potency (by antiviral activity in cell culture). Upon receipt, the candidate RS was verified for compliance with regulatory specifications. According to the test results, the potency of the candidate pharmacopoeial RS was 4.47×10⁸ IU/mL, and the expanded uncertainty was 8.12×10⁷ IU/mL, with a coverage factor of k=2 and a confidence level of 95%. The pharmacopoeial RS for rhIFN α-2b was considered to have the same shelf-life period as the corresponding medicinal products if stored at a temperature not higher than –40 ºC. When thawed, the pharmacopoeial RS for rhIFN α-2b can be stored at a temperature of 2–8 ºC for up to 1 month.CONCLUSIONS. Upon certification for potency testing, the pharmacopoeial RS for rhIFN α-2b has been included in the Register of Reference Standards of the Russian Pharmacopoeia as Recombinant Human Interferon α-2b (Potency) FSO.3.2.00455. The introduction of this pharmacopoeial RS will help to conduct the identification and potency testing of all Russian interferon α-2b products at an appropriate scientific and methodological level. As a result, Russian pharmaceutical manufacturers and quality control agencies will no longer depend on imported ISs.
Production and immunological characterisation of recombinant flagellin C of <i>Pseudomonas aeruginosa</i>
Authors: Zherebtsov A. P. , Kaloshin A. A. , Mikhailova N. A. 
Published: March 2024

SCIENTIFIC RELEVANCE. Pseudomonas aeruginosa is one of the main causative agents of focal and diffuse suppurative inflammations in immunocompromised individuals. The multiple antimicrobial resistance of Р. aeruginosa has created an urgent need to develop effective preventive vaccines against this bacterium and to enhance their protective properties by selecting adjuvants. A promising strategy is to use flagellin, a P. aeruginosa flagellum component inducing the innate immune system through interaction with toll-like receptor 5 (TLR5) and activating the T-cell immune response, as a component or adjuvant in vaccine development.AIM. This study aimed to produce recombinant flagellin C (FliC) of P. aeruginosa and investigate its immunogenicity, adjuvanticity, and protective properties.MATERIALS AND METHODS. The fliC nucleotide sequence was obtained by PCR on template DNA of P. aeruginosa PA-103 and was inserted into the pQE-30 plasmid for subsequent expression in Escherichia coli M15. Recombinant FliC purification involved two stages: isolation of inclusion bodies and their dissolution in buffers containing urea and guanidine hydrochloride. Mice were immunised by two intraperitoneal injections with a two-week interval. The immunisation used purified recombinant FliC at a dose of 50 μg per animal and its combination with the Klebsiella pneumoniae surface antigen in a 1:1 ratio. Serum samples from immunised mice were tested for specific antibodies to recombinant FliC by enzyme-linked immunosorbent assay (ELISA). The protective properties of FliC were assessed by intraperitoneal challenge of mice with cultures of P. aeruginosa PA-103 and K. pneumoniae 204.RESULTS. The authors obtained the producing strain, generated recombinant FliC, and purified the protein to a 97.6% purity. The analysis of serum samples from immunised mice by ELISA and the protection assessment in challenge experiments showed that the purified recombinant FliC protein had immunogenic properties. Furthermore, the experimental challenge of FliC-immunised mice with P. aeruginosa confirmed that recombinant FliC had protective properties, as evidenced by the protection index of 3.0. Recombinant FliC exhibited adjuvant properties, as demonstrated by the effectiveness index of 6.1 observed in the experimental challenge of mice immunised with the combination of recombinant FliC and the surface antigen of K. pneumoniae.CONCLUSIONS. The purified recombinant FliC protein of P. aeruginosa demonstrated protective activity in mice challenged with P. aeruginosa and adjuvant properties when combined with the K. pneumoniae surface antigen, increasing the immunogenicity of the latter. The use of recombinant FliC holds promise for the creation of a candidate vaccine against P. aeruginosa infection.
Memory, Trauma, and Liturgies of Exile in Baruch 1:1–3:8
Authors: Wilson Walter T. 
Published: March 2024

Abstract
The book of Baruch describes a set of penitential rituals ostensibly established early in the exilic period to be performed by worshipping assemblies in Babylon and Jerusalem. Prominence is assigned to the ceremonial recitation of a book composed by Baruch in Babylon, which becomes the basis of a letter sent by the exiles to the priests in Jerusalem for use in temple liturgies (1:1–14). As they hear the first part of the book (1:15–3:8), worshippers develop reflexive modes of awareness as they encounter various configurations of time and space, thereby performing exilic subjectivities through which they internalize “prosthetic” memories of loss, subjugation, and disaffection.
Purity, Cult, and Empire
Authors: Rhyder Julia 
Published: March 2024

Abstract
This article analyzes the proclamation of Antiochus III concerning the temple and city of Jerusalem, quoted in Ant. 12.145–46, in light of three sets of evidence: Greek comparative materials from the broader Mediterranean world; biblical and Second Temple writings; and archaeological remains from Hellenistic Jerusalem, especially those that attest to the presence of non-sacrificial animals in the city. The evidence suggests that Ant. 12.145–46 preserves traces of an authentic proclamation, written in the style of a Greek ritual norm and probably with royal backing. We should not conclude from this, however, that the proclamation reflects the reality of how all Jews in Jerusalem conceptualized the purity of the temple and their obligations when butchering and tanning their animals within the city. I rather argue for a more complex interpretive approach that views royal edicts as fueling local debates surrounding temple purity, the sacred economy, and priestly prerogatives in Hellenistic Jerusalem.
Advantages of A-USC for CO2 Capture in Pulverized Coal Units
Authors: Hendrix H.L. 
Published: March 2024

Abstract
Increasing the steam temperature of a coal-fired pulverized coal (PC) power plant increases its efficiency, which decreases the amount of coal required per MW of electrical output and therefore decreases the emissions from the plant, including CO2. However, increasing the steam temperature requires that the materials for the boiler pressure parts and steam turbine be upgraded to high-nickel alloys that are more expensive than alloys typically used in existing PC units. This paper explores the economics of A-USC units operating between 595°C and 760°C (1100°F to 1400°F) with no CO2 removal and with partial capture of CO2 at an emission limit of 454 kg CO2/MW-hr (1000 lb CO2/MW-hr) on a gross power basis. The goal of the paper is to understand if the improved efficiency of A-USC would reduce the cost of electricity compared to conventional ultra-supercritical units, and estimate the economically “optimal” steam temperature with and without CO2 removal.
Investigations on Nickel Based Alloys and Welds for A-USC Applications
Authors: Klenk Andreas , Maile Karl 
Published: March 2024

Abstract
In several material qualification programs tubes and thick-walled components mainly from Alloy 617 and Alloy 263 were investigated. Results as low cycle fatigue and long term creep behavior of base materials and welds are presented. Numerical models to describe the material behavior have been developed and verified by multiaxial tests. In order to ensure the feasibility of A-USC plants two test loops have been installed in GKM Mannheim – one for tube materials and a new one for thick-walled piping and components. The latter consists of a part with static loading and a part subjected to thermal cycles and is in operation since November 2012. First results of measurements and numerical calculations for a pipe bend (static loading) as well as pipes and a header (thermal cycles) are presented.
Creep Crack Growth Behavior as a Superalloy Selection Consideration for A-USC Power Plant Applications
Authors: Mueller Falk , Scholz Alfred , Oechsner Matthias 
Published: March 2024

Abstract
To improve efficiency and flexibility and reduce CO2 emissions, advanced ultra super critical (AUSC) power plants are under development, worldwide. Material development and its selection are critical to the success of these efforts. In several research and development programs / projects the selection of materials is based on stress rupture, oxidation and corrosion tests. Without doubt, these criteria are important. To improve the operational flexibility of modern power plants the fatigue properties are of increased importance. Furthermore, for a safe operation and integrity issues the knowledge about the crack behavior is essential. Crack initiation and crack growth may be caused by natural flaws or cracks induced by component operation. In order to develop new materials, properties like tensile strength and creep strength are an important part of qualification and subsequent approval by notified bodies. Consequently short term properties as well as time-temperature dependent properties are generated and taken into considerations. In the case of high strength γ'-strengthening nickel-base alloys investigating the creep crack behavior is also strongly recommended. This article shows results of currently investigated nickel-based alloys for newly developed headers, pipes and other high temperature boiler applications and their critical creep crack propagation behavior.