bluuebunny/crossref_metadata_2025_split huggingface dataset:
Finding the paths between job demand–resources and turnover intention of community mental health nurses in Korea
Authors: Hwang Eunmi , Yi Yeojin 
Published: February 2025

AbstractAimThis study aimed to investigate the pathways between client violence, supervision, workplace spirituality, burnout, work engagement, and turnover intention in community mental health nurses using the job demand–resources model with the goal of reducing turnover and improving workforce retention.BackgroundHigh turnover of nurses has a negative impact on the rehabilitation and recovery of people with mental illness. While individual factors influencing turnover intention are well studied, there is a lack of research on the dynamics between variables and what should be focused on.MethodsParticipants were 243 mental health nurses working in the community health organizations. Data were collected through online questionnaires in April 2022 and analyzed using path analysis.ResultsClient violence against nurses as a job demand directly and indirectly negatively affected turnover intention through burnout. Supervision as a job resource only directly decreased turnover intention without mediating factors. Workplace spirituality as a personal resource indirectly lowered turnover intention through work engagement.ConclusionWe need to focus more on organizational issues first, such as workplace safety (client violence) and administrative support (supervision) related to the nurses' turnover intention, and then on individual issues (workplace spirituality).Implications for nursing practiceThe worst path (client violence to burnout) to accelerate turnover intention of the nurses must be managed and disconnected, while the best path (from workplace spirituality to work engagement) to lower turnover intention should be maintained.Implications for nursing and health policyPolicymakers should extend Workplace Safety Legislation to community organizations less well‐served by the laws and incorporate supervision into organizational evaluation items and curricula. Collaboration between community organizations and law enforcement is essential to enhance safety and support for the nurses.
How We Might Best Develop and Deliver Training and Professional Development in Positive Behaviour Support: A Systematic Review
Authors: Hall Julia R. , Newton Danielle , McVilly Keith , McKay‐Brown Lisa , Hayward Brent , Uljarevic Mirko 
Published: February 2025

ABSTRACTWhat constitutes good clinical practice in positive behavioural support (PBS) is well established. But how these clinical principles and practices are best translated into education, training and professional development remain unclear. To inform the development of a national blueprint to support education and professional development in PBS, we sought to better understand current approaches to training and education in PBS, its content and delivery. A systematic review of PBS interventions involving staff training was conducted within the timeframe of 1999–2023. Seven databases and one specialist journal (not otherwise indexed) were searched. Articles were identified using key search words; that is, ‘positive behaviour support’, ‘disability’ and ‘training’. Thirty‐three articles were identified whose predominant aims were to evaluate the impact and/or efficacy of PBS‐based training. Training formats included workshops, lectures, modules, classroom/group instruction and team‐based learning through the review of PBS plans. Core content focused on functional behaviour analysis, behaviour support planning, behaviour support strategies and interventions, as well as skills training. Articles reflected similar core content; however, there was a lack of consistency in training delivery, methodology and subsequent outcomes. Despite this, the literature provides evidence to inform the development of a future capabilities framework and guidance on the training, education and professional development of those involved in the delivery of PBS. Subsequently, recommendations are made to inform the education, training and professional development of PBS practitioners and those responsible for the coordination and delivery of support services for people who exhibit challenging behaviour.
Examining the Effect of Wrongful Discharge Laws on Women's Occupational Employment
Authors: Hoyt Eric , Kurtulus Fidan Ana 
Published: February 2025

ABSTRACTPrevious empirical literature on US wrongful discharge laws, a judicial form of employment protection, has identified ways in which these policies have changed employers' hiring and firing practices, but has lacked a systematic analysis of the impact on workplace gender composition. This paper is the first to investigate the impact of state adoption of wrongful discharge laws on occupational gender diversity within American workplaces. We use restricted establishment‐level longitudinal data that are uniquely suited for the analysis of this topic obtained from the United States. Equal Employment Opportunity Commission (EEO‐1 Employer Information Reports). We utilize difference‐in‐differences regression methodology to first estimate the overall impact of wrongful discharge laws, and then examine the dynamics of wrongful discharge law impacts using event study regressions. We then examine the interplay between state wrongful discharge laws and state gender employment discrimination laws in shaping female employment composition at workplaces. First, we find that the adoption of one wrongful discharge law in particular, the good faith doctrine, is associated with an increase in women's employment share in laborer jobs within private‐sector establishments of 0.80 percentage points, and that this is a causal impact given the pattern of yearly impacts found using our event study analysis. Our findings suggest that the good faith doctrine has facilitated reduction in barriers women have historically faced in blue‐collar jobs. Second, while we find that the good faith doctrine is associated with a statistically significant increase in the share of women in officer and managerial jobs, and that the public policy doctrine is associated with a significant rise in women's share of professional jobs, our event study results cast doubt that these are causal impacts. Finally, our exploration of the interaction between state wrongful discharge laws and state gender discrimination laws reveals that, generally, state gender discrimination laws neither amplify nor diminish the impact of wrongful discharge laws on women's occupational employment within establishments.
Drug‐Induced Liver Injury Caused by Metamizole: Identification of a Characteristic Injury Pattern
Authors: Weber Sabine , Erhardt Franziska , Allgeier Julian , Saka Didem , Donga Nirali , Neumann Jens , Lange Christian M. , Gerbes Alexander L. 
Published: February 2025

ABSTRACTBackground and AimsDrug‐induced liver injury (DILI) due to metamizole has gained increasing attention. Causality assessment remains a challenge, especially in patients with co‐medications. We therefore aimed to further characterise metamizole DILI cases.MethodsThe data of patients with metamizole intake from our prospective study on acute liver injury with potential drug‐related causes were analysed. Diagnosis and causality assessment were based on a thorough work‐up and long‐term follow‐up.ResultsDILI was associated with metamizole in 61 of 324 DILI patients (prevalence 18.8%). A highly characteristic clinical pattern was observed in 43 of the 61 patients, characterised by marked elevation of transaminases peaking at the time of DILI recognition and a more pronounced increase of bilirubin within the first 3 days of clinical presentation. Patients fitting this picture had higher rates of jaundice, coagulopathy, and acute liver failure, however outcomes did not differ significantly when compared to non‐metamizole DILI and autoimmune hepatitis (AIH) patients. Overall, fatal adverse outcomes defined by death or liver transplantation were observed in 13.1% of metamizole DILI patients. On multivariate analysis, only aspartate aminotransferase (AST) and INR were independently associated with a fatal adverse outcome. INR, in particular, performed better than Hy's law, bilirubin, transaminases, and the model for end‐stage liver disease (MELD), with a c‐statistic of 0.85 (95% CI: 0.70–1.0). At a cut‐off of ≥ 2.1, sensitivity and specificity for a fatal adverse outcome were 75% and 96%, respectively.ConclusionsMetamizole DILI can present with a characteristic pattern that can help clinicians to identify metamizole as the causative agent. Outcome, however, is not associated with this clinical picture and should rather be predicted by INR at onset.Trial RegistrationClinicalTrials.gov identifier: NCT 02353455
Topological Distribution of KCNH2 Variants and Genotype‐Phenotype Relationship in Patients With Long QT Syndrome
Authors: Liu Hongyu , Jiang Zhenhong , Shen Yang , Shao Ying , Su Yuhao , Wang Daowu , Brugada Ramon , Hong Kui 
Published: February 2025

ABSTRACTAimsThe aim of this study was to investigate the topological distribution of single nucleotide variants (SNVs) in the KCNH2 gene from patients with type 2 long QT syndrome (LQT2) and to explore the genotype‐phenotype relationships.MethodsInformation on KCNH2 variants in LQT2 patients was retrospectively obtained from the HGMD, ClinVar, and PubMed databases through October 2022. Pathogenicity of SNV was classified according to the American College of Medical Genetics and Genomics (ACMG) guidelines. Unpaired t‐tests and Fisher's exacts were used to analyze the SNV distributions across structural and functional domains, and their correlation with clinical phenotypes.ResultsA total of 2826 variants were obtained; 2152 were SNVs, 1328 of which were nonsynonymous SNVs (nsSNVs) associated with LQT2. Enrichment analysis revealed that 602 pathogenic (P) and likely pathogenic (LP) nsSNVs were significantly enriched at S5, H5, S6, Extra3, and Extra4. In addition, 759 nsSNVs and 289 P/LP nsSNVs within function domain were enriched at the per‐arnt‐sim (PAS) and selectivity filter (SF) functional domain. Clinical data revealed that patients with nsSNVs enriched at the N‐terminal, S5‐H5‐S6 region and PAS domain were associated with an increased risk of syncope. Moreover, nsSNVs located at the N‐terminal, S5‐H5‐S6 region, and PAS, SF domains were associated with an increased risk of life‐threatening cardiac events, including Torsade de Pointes (TdP) and sudden cardiac death (SCD), and were predominantly female.ConclusionKCNH2 nsSNVs located at the N‐terminal, S5‐H5‐S6 region, and the PAS and SF functional domains are associated with an increased risk of life‐threatening cardiac events in LQT2 patients.
Role of Routine Electrophysiological Study Performed During Transcatheter Aortic Valve Replacement to Predict AV Block
Authors: Pagnoni Mattia , Meier David , Luca Adrian , Fournier Stephane , Aminfar Farhang , Haddad Christelle , Maurizi Niccolo , Domenichini Giulia , Le Bloa Mathieu , Herrera Siklody Claudia , Teres Cheryl , Cook Stephane , Goy Jean‐Jacques , Togni Mario , Roguelov Christan , Girod Grégoire , Rubimbura Vladimir , Dupré Marion , Eeckhout Eric , Pruvot Etienne , Muller Olivier , Pascale Patrizio 
Published: February 2025

ABSTRACTBackgroundPeriprocedural electrophysiological (EP) testing may be useful to predict high degree atrioventricular block (HAVB) risk in patients undergoing transcatheter aortic valve replacement (TAVR).ObjectiveTo determine whether pre‐ and immediate post‐TAVR ECG and HV interval findings are predictive of HAVB.MethodsConsecutive TAVR patients without prior pacemaker (PM) implantation underwent ECG and standardized HV interval measurements pre‐ and post‐TAVR using the quadripolar catheter for rapid pacing. The primary outcome was HAVB >24 h after TAVR or ventricular pacing needResultsOut of 97 included patients, 8 experienced the primary outcome (7 with HAVB and 1 with PM need). On univariate analysis, pre‐ and post‐TAVR PR, post‐TAVR HV, and Delta‐HV intervals were predictors of the primary outcome. A Delta‐HV interval ≥18 ms predicted HAVB with sensitivity = 50% and specificity = 90% (AUC = 0.708, PPV = 31%), while an HV interval ≥60 ms after TAVR had sensitivity = 63% and specificity = 79% (AUC = 0.681, PPV = 21%). None of the patients with a PR interval ≤180 ms post‐TAVR experienced the primary outcome. Among patients with new‐onset LBBB, an HV interval post‐TAVR >65 ms was the only predictor of HAVB (AUC = 0.776, PPV = 33%, and NPV = 97%).ConclusionThe yield of periprocedural EP assessment during TAVR is limited considering that about half of the at‐risk patients fail to be identified. However, early periprocedural risk stratification may be more useful in the subset of patients with new‐onset LBBB. Among ECG findings, a post‐TAVR PR interval ≤180 ms identifies a subgroup at very low risk, independently of QRS interval and morphology.
Association of Cerebral Palsy With Unanticipated Admission Following Pediatric Ambulatory Surgery
Authors: Shamansky Nina , Mpody Christian , Nafiu Olubukola O. , Tobias Joseph D. , Willer Brittany L. 
Published: February 2025

ABSTRACTBackgroundCerebral palsy, a neurologic disorder caused by damage to the developing brain, is a leading cause of childhood disability. Due to musculoskeletal, movement, and secondary impairments, children with cerebral palsy often require surgical care. With the growing cost of surgical care, many children with cerebral palsy are scheduled for surgery in an ambulatory setting. Whether cerebral palsy increases the risk of unanticipated admission (a critical quality indicator of care) following ambulatory surgery has not been characterized. Our objective was to determine the association of cerebral palsy with unanticipated admission following pediatric ambulatory surgery.MethodsWe used the Pediatric Health Information System (PHIS) database to evaluate a retrospective cohort of children (< 18 years) who underwent scheduled ambulatory operations between January 1, 2010 and December 31, 2022. The primary outcome was unanticipated admission. Using log‐binomial regression models, we estimated the relative risk and 95% confidence intervals for unanticipated admission, comparing patients with and without cerebral palsy. To account for confounding variables, we performed a 1:1 propensity score matching without replacement.ResultsA total of 1 954 108 children underwent ambulatory surgeries during the study period. Of these, 4.1% required unanticipated admission. The overall incidence of unanticipated admission was significantly higher among children with cerebral palsy than in those without (9.8% vs. 4.0%; p < 0.001). This association remained significant after multivariable adjustment (relative risk: 1.73; 95% CI: 1.59–1.87, p < 0.001).ConclusionAlthough cerebral palsy is not a contraindication for ambulatory surgery in children, it is significantly associated with the risk of unanticipated hospital admissions. This underscores the need for careful preoperative clinical site of care selection in this vulnerable patient population.Level of EvidenceLevel II.
Review Essay—Territorial Politics and COVID: A Comprehensive Review
Authors: Hernández‐Moreno Jorge , Harguindéguy Jean‐Baptiste , Carrasco‐Ariza Beatriz 
Published: February 2025

ABSTRACTAs part of a broader research programme on the federal governance of COVID‐19 in Spain, this systematic literature review centers on the nexus between territorial politics and the coronavirus crisis. It analyses 300 publications in the Web of Science Core Collection from 2018 to 2023 through the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) method. The article contains three sections. The first one reports that these items were published during a very short period by a limited number of authors and universities supported by public funds. Second, the article stresses the importance of federal architecture by highlighting the debate on recentralization, the weight of intergovernmental relations to guarantee policy efficiency, and the dilemma of policy instruments and intersectoral action. Finally, the review points out the significance of politics during the pandemic, exemplified by the rise of polarization, the role of central leadership, and the upsurge of a new cleavage centered on COVID‐19.Related ArticlesLauby, Fanny, and Christopher J. McKinley. 2023. “Factors of Early COVID‐19 Prevention Policy Engagement in France and in the United States.” Politics & Polciy 51(5): 830–48. https://doi.org/10.1111/polp.12556.Robles, Pedro, and Daniel J. Mallinson. 2023. “Review Essay—Catching Up with AI: Pushing toward a Cohesive Governance Framework.” Politics & Policy 51(3): 355–72. https://doi.org/10.1111/polp.12529.Tyner, Katie, and Farida Jalalzai. 2022. “Women Prime Ministers and COVID‐19: Within‐case Examinations of New Zealand and Iceland.” Politics & Policy 50(6): 1076–95. https://doi.org/10.1111/polp.12511.
Populism and Psychological Involvement in the 2020 US Presidential Election
Authors: Mangum Maruice 
Published: February 2025

ABSTRACTIn recent election cycles, especially during the 2020 US presidential election cycle, individuals displayed a renewed and heightened sense of civic, social, and political involvement. Voter turnout was high in the 2020 presidential election, the highest for any other presidential election since 1900. I submit that the psychological influences of populism and psychological involvement foster this high turnout. Using the 2020 American National Election Study, this article examines their influences on political behavior. It places greater focus on populism because scholars of American elections rarely test it as an individual‐level force in presidential elections and because scholars do not examine it with psychological involvement simultaneously. I find that populism and psychological involvement are distinct concepts, both boost voter turnout, and they shape vote choice and candidate affect.Related ArticlesAguado, N. A. 2022. “When Charismatic Leadership Trumps Social Networking: Searching for the Effects of Social Media on Beliefs of Electoral Legitimacy.” Politics & Policy 50, no. 5: 942–951. https://doi.org/10.1111/polp.12494Craig, S. C., and J. Gainous. 2024. “To Vote or Not to Vote? Fake News, Voter Fraud, and Support for Postponing the 2020 U.S. Presidential Election.” Politics & Policy 52, no. 1: 33–50. https://doi.org/10.1111/polp.12577Deegan‐Krause, K., and T. Haughton. 2009. “Toward a More Useful Conceptualization of Populism: Types and Degrees of Populist Appeals in the Case of Slovakia.” Politics & Policy 37, no. 4: 821–841. https://doi.org/10.1111/j.1747‐1346.2009.00200.x
Prediction of higher ceftazidime–avibactam concentrations in the human renal interstitium compared with unbound plasma using a minimal physiologically based pharmacokinetic model developed in rats and pigs through microdialysis
Authors: Vallée Maxime , Aranzana-Climent Vincent , Moreau Jérémy , Lamarche Isabelle , Fontanier Théo , Barc Céline , Kasal-Hoc Nathalie , Debiais-Delpech Céline , Mirfendereski Hélène , Pezant Jérémy , Pinard Anne , Clarhaut Jonathan , Couet William , Cazenave-Roblot France , Marchand Sandrine 
Published: February 2025

ABSTRACT

Last resort antibiotics, like ceftazidime–avibactam (CZA), were used to treat urinary tract infections caused by multidrug-resistant bacteria. However, no data on tissue distribution were available. Our aim was to describe the
in vivo
kidney distribution of CZA in healthy rats and pigs using a physiologically based pharmacokinetic model (PBPK). Microdialysis probes were inserted into the blood, muscle, and kidney of both species. The experiment started with a retrodialysis by drug period. An i.v. single dose of CZA was administered. Samples were collected for 3 h in rats and 7 h in pigs. A PBPK model was developed to describe tissue and blood CZA pharmacokinetics in animals and to predict human concentrations. The PBPK model adequately described CZA rat and pig data in each tissue and blood. In both species, the concentration profiles of CZA in muscle and blood were almost superimposed, with muscle-to-plasma area under the curve (AUC) ratios close to one. However, kidney CZA concentrations were higher than those in blood, as indicated by kidney-to-plasma AUC ratios exceeding one (respectively 2.27 in rats and 2.63 in pigs for ceftazidime [CAZ]; 2.7 in rats and 4.5 in pigs for avibacam [AVI]). Prediction of human concentrations led to same observations. This study demonstrated an excellent penetration of CZA into the renal parenchyma of rats and pigs. Our PBPK model adequately described the data, and AUCs were higher in the renal cortex interstitium compared with unbound plasma. Our data suggested that the joint PK/PD target for CZA in humans could be attained with reduced CZA doses.
Structural mapping of polyclonal IgG responses to HA after influenza virus vaccination or infection
Authors: León André Nicolás , Rodriguez Alesandra J. , Richey Sara T. , Torrents de la Pena Alba , Wolters Rachael M. , Jackson Abigail M. , Webb Katherine , Creech C. Buddy , Yoder Sandra , Mudd Philip A. , Crowe James E. , Han Julianna , Ward Andrew B. 
Published: February 2025

ABSTRACT

Cellular and molecular characterization of immune responses elicited by influenza virus infection and seasonal vaccination have informed efforts to improve vaccine efficacy, breadth, and longevity. Here, we use negative stain electron microscopy polyclonal epitope mapping (nsEMPEM) to structurally characterize the humoral IgG antibody responses to hemagglutinin (HA) from human patients vaccinated with a seasonal quadrivalent flu vaccine or infected with influenza A viruses. Our data show that both vaccinated and infected patients had humoral IgGs targeting highly conserved regions on both H1 and H3 subtype HAs, including the stem and anchor, which are targets for universal influenza vaccine design. Responses against H1 predominantly targeted the central stem epitope in infected patients and vaccinated donors, whereas head epitopes were more prominently targeted on H3. Responses against H3 were less abundant, but a greater diversity of H3 epitopes were targeted relative to H1. While our analysis is limited by sample size, on average, vaccinated donors responded to a greater diversity of epitopes on both H1 and H3 than infected patients. These data establish a baseline for assessing polyclonal antibody responses in vaccination and infection, providing a context for future vaccine trials and emphasizing the need for further characterization of protective responses toward conserved epitopes. (201 words)

IMPORTANCE
Seasonal influenza viruses cause hundreds of thousands of deaths each year and up to a billion infections; under the proper circumstances, influenza A viruses with pandemic potential could threaten the lives of millions more. The variable efficacies of traditional influenza virus vaccines and the desire to prevent pandemic influenzas have motivated work toward finding a universal flu vaccine. Many promising universal flu vaccine candidates currently focus on guiding immune responses to highly conserved epitopes on the central stem of the influenza hemagglutinin viral fusion protein. To support the further development of these stem-targeting vaccine candidates, in this study, we use negative stain electron microscopy to assess the prevalence of central stem-targeting antibodies in individuals who were exposed to influenza antigens through traditional vaccination and/or natural infection during the 2018–2019 flu season.