bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementation of a Value-Based Approach for Older People Who Have Suffered an Acute Myocardial Infarction: Study Protocol
Authors: Juraga Denis , Rukavina Tomislav , Glavić Mihaela Marinović , Bilajac Lovorka , Bally Esmee , Zanutto Oscar , Alhambra-Borrás Tamara , Ferrando Maite , Subotić Alen , Raat Hein , Vasiljev Vanja 
Published: April 2024

Abstract

Background: Due to the rapid aging of the global population, new approaches are required to improve the quality of life of older people and to reduce healthcare system expenditures. One of the approaches that can be used is value-based healthcare. This article describes a value-based solution for older people who have suffered a myocardial infarction.
Methods: This solution combines the work of healthcare professionals and informal caregivers and the use of modern and user-friendly technologies to support the achievement of patients’ values. Patients older than 65 years who have suffered a myocardial infarction will be divided into control and intervention groups. Members of the intervention group will be provided with a personalized plan developed by healthcare professionals and based on the results from the baseline questionnaire.
Discussion: Two ValueCare digital solution components will be developed: a mobile application for the participants and a web platform for the professionals, researchers, and informal caregivers. Together with smartwatches, which will track important health aspects, and applications, this approach would enable older people to improve their health through correct lifestyle choices and their professional and informal caregivers to track their progress. With the use of the described technology and the multidisciplinary approach, the unmet needs and values of participants could be achieved. Using this approach, it could be possible to reduce overall healthcare expenses through the active involvement of both older people and their informal caregivers through a shared decision-making process with healthcare professionals.
The ISRCTN registry number is 25089186. The date of trial registration is 16/11/2021.
Content Validity of Patient-Reported Measures Evaluating Experiences of the Quality of Transitions in Healthcare Settings - A Scoping Review.
Authors: Walløe Sisse , Roikjær Stine Gundtoft , Hansen Sebrina Maj-Britt , Zangger Graziella , Mortensen Sofie Rath , Korfitsen Christoffer Bruun , Simonÿ Charlotte , Lauridsen Henrik Hein , Morsø Lars 
Published: April 2024

Abstract

No reviews so far have been conducted to define the constructs of patient-experienced quality in healthcare transitions or to identify existing generic measures of patients’ experience of the quality within healthcare transitions. Our aim was to identify domains relevant for people experiencing healthcare transitions when evaluating the quality of care they have received, map the comprehensiveness of existing PREMs, and evaluate the PREMs’ content validity. The methods was guided by the Joanna Briggs Institutes’ guidance for scoping reviews. The search was performed on 07 December 2021, in the electronic databases Medline (Ovid), Embase (Ovid), and Cinahl (EBSCO). The search identified 16,134 publications, and 172 studies were included for review. We identified 29 PREMs assessing at least one aspect of adults’ experience of transitions in healthcare. Summarising the content, we consider a model with two domains, organisational and human-relational, likely to be adequate. However, a more comprehensive analysis and adequate definition of the construct is needed. None of the PREMs were considered content valid.
A pan-cancer analysis of the oncogenic and anti-tumor immunity role of P4HA3 in human cancers
Authors: Huang Hongyan , Huang Yong-Sheng , Xiao Yan-Hong , Jin Hai-Yun , Zhu Di , Yi Xiao-Lin , Lin Xiao-Hua , Jin Ming , Yu Jie , Huang Jing , Ren Shuwei 
Published: April 2024

Abstract
Background Prolyl-4-hydroxylase subunit alpha3 (P4HA3) is a triple helical procollagen synthesis protein. The role of P4HA3 in cancer development is not well known and lacks comprehensive analyses among human cancers. This study aimed to investigate the relationship between P4HA3 expression and anti-tumor immunity and its prognostic value in pan-cancer.
Methods P4HA3 expression in pan-cancer patients were analyzed from TIMER2.0, Genotype Tissue Expression (GTEx), GEPIA2.0 and TCGA databases. Genetic and DNA methylation alterations, survival analysis and proteins co-expression analysis of P4HA3 in pan-cancer among numerous databases, including cBio Cancer Genomics Portal, TCGA, GSCA and TIMER2.0. The correlation between P4HA3 expression and immune infiltration was analyzed TIDE, XCELL, MCPCOUNTER, and EPIC. Gene function enrichment analysis was carried out by Gene Set Enrichment Analysis (GSEA). We performed EdU and transwell experiments to evaluate the influence of P4HA3 on the proliferation, migration and invasion abilities of 3 kinds of tumors in vitro. Patients derived xenograft (PDX) and subcutaneous transplantation models were utilized to explore the correlation between P4HA3 and immunotherapy response in triple-negative breast cancer (TNBC).
Results Among 33 types of cancers, P4HA3 had generally different expression between tumor and tumor tissues, the abnormal expression of P4HA3 was associated with DNA methylation alteration and survival regimen of tumor patients. Further analysis showed that the expression of P4HA3 was correlated with the cells infiltration of the tumor microenvironment (TME), including immune cells, cancer-associated fibroblasts (CAFs), and stroma cells. Meanwhile, the expression of P4HA3 was positively with the cell proliferation markers and epithelial-mesenchymal transition (EMT) markers, that suggesting P4HA3 is involved in cancer proliferation and metastasis. Moreover, the molecular biology experiments in vitro and in vivo showed that P4HA3 deficiency inhibited the proliferation, migration and invasion abilities of tumor cells, and promoted anti-tumor immunotherapy of PD-1/PD-L1 inhibitor.
Conclusion This pan-cancer analysis of P4HA3 provides a comprehensive understanding of its oncogenic and prognosis role in different cancers, P4HA3 abnormal expression could be a useful biomarker for predicting the effectiveness of immunotherapy in cancer patients.
Obesity and Risk of Hypertension in Preadolescent Urban School Children: Insights from a Developing Country
Authors: Akhtar Samina , Khan Shahid , Aziz Namra , Magsi Muhammad Imran , Samad Zainab , Iqbal Romaina , Almas Aysha 
Published: April 2024

Abstract
Background
Childhood obesity and hypertension are growing concerns globally, especially in developing countries. This study investigated the association between overall and central obesity at baseline, and prehypertension or hypertension at follow-up among preadolescent school children in Karachi, Pakistan.
Methods
This is a sub study with cohort design embedded within a feasibility trial on School Health Education Program in Pakistan (SHEPP) in preadolescent aged 6–11 years, attending two private schools, were enrolled from 2017 to 2019. Hypertension or prehypertension at follow-up were the outcomes and obesity or central obesity at baseline were the exposure variables. Hypertension was defined as systolic blood pressure and/or diastolic blood pressure ≥ 95th percentile for age, sex, and height. Obesity was defined as body mass index for-age and sex ≥ 95th percentile, whereas central obesity was determined by waist circumference measurements ≥ 85th percentile of age, sex, and height specific cut-offs. Logistic regression analysis was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) to identify risk factors for hypertension and prehypertension.
Results
Analysis was conducted for 908 participants, evenly distributed with 454 boys and 454 girls. Hypertension was observed in 19.8% of the preadolescents, with rates of 18.5% in boys and 21.0% in girls. Prehypertension was found in 16.8% of preadolescents, with 18% among boys and 16% among girls. Additionally, 12.8% of preadolescents were classified as obese and 29.8% had central obesity. Obesity at baseline was associated with hypertension (OR 8.7, 95% CI 3.5, 20.4) in the final model after adjusting for age, gender, physical activity, sedentary behavior, fruits, vegetable intake and hypertension at baseline. Central obesity at baseline also yielded high odds, with prehypertension (OR 1.9, 95% CI 1.4, 2.8) and hypertension (OR 2.7, 95% CI 1.9, 3.9) in the final model.
Conclusion
This study highlights a concerning prevalence of hypertension and prehypertension among preadolescent school-going children. Obesity and central obesity at baseline emerged as significant predictive factors for hypertension within this cohort. The findings emphasize the urgency of implementing comprehensive school health education programs aimed at early detection and effective management of hypertension during childhood and adolescence in school settings.
Structural Properties of Al-Li-Zn Borate glass activated with Dy3+ for Radiation Dosimeter
Authors: Efenji G. I. , Iskandar S. M. , Yusof N. N. , A. Rabba J. , Jamil Munirah , kamgba F. A. , Ushie P. , Umar S. A. , Ezra NABASU Seth , Khazaalah Thair Hussein , Naeem Hayder Salah , Oke A.O 
Published: April 2024

Abstract
This study explores the properties of Al-Li-Zn glass doped with Dy3 + as a potential radiation dosimeter. The glass was prepared using the quenching technique, and various characterisations were performed to evaluate its properties. X-ray diffraction (XRD) analysis was utilised to identify any crystalline or amorphous phases in the glass. The results indicated the formation of amorphous, as supported by the absence of XRD peaks. UV-vis spectroscopy was employed to examine the optical properties of the glass. It revealed a noticeable absorption peak in the visible region, characteristic of the Dy3 + ions. PL spectra luminous peaks at 348 nm (yellow), 529 nm (green), and 625 nm (orange hue), which corresponded to the 4H15/2 → 6P7/2, 4F9/2 → 6H15/2, 4F9/2 → 6H15/2, and 4F9/2 → 6H13/2 transitions in 1.5 and 2.5 Dy3 + respectively. Significant decrease in \({\text{T}}_{\text{g}}\)from 257°C in the undoped sample to 101°C in the doped sample, Tm of the doped sample dropped from 862°C to 815°C and Tc of the doped sample dropped from 756°C to 444°C, suggesting a reduced crystallisation threshold. FTIR analysis demonstrated that OH groups displayed peaks within the 2200 to 4000 cm range. Stretching vibrations of BO3 units occurred between 1200 and 1600. Stretching vibrations of BO4 units were observed between 800 and 1200. The results indicate that when Dy3 + ions and zinc oxide are added, the arrangement of the glass structure is altered, causing a transformation from B03 groups to B04 groups. This transformation leads to defects in a stable trap environment suitable for thermoluminescence phenomena. Considering its properties and optical characteristics, the samples with 1.5 and 2.5 mol % of Dy3 + showed remarkable thermoluminescence properties, suggesting a suitable use as a dosimeter to gauge radiation exposure. The glass demonstrates stability and absorption capability, making it worth considering for radiation detection applications.
Salix species and varieties affect the molecular composition and diversity of soil organic matter
Authors: Dufour Louis J.P. , Wetterlind Johanna , Nunan Naoise , Quenea Katell , Shi Andong , Weih Martin , Herrmann Anke M. 
Published: April 2024

Abstract
Background and aims
Most studies of the relationships between the composition of soil organic matter and plant cover have been carried out at the plant genera level. Yet, they have largely overlooked the potential effects that plant varieties belonging to the same genus can have on soil organic matter.
Methods
We investigated whether plant varieties belonging to different Salix species (S. dasyclados and S. viminalis) impacted the composition of organic matter using mid-infrared spectroscopy and pyrolysis GC/MS. Top-soils (0-20 cm) were taken from an 18 year-old long-term field trial where six Salix varieties were grown as short-rotation coppice under two fertilisation regimes.
Results
Significant differences in the molecular composition and diversity of the soil organic matter were observed in the fertilised plots. The effects were mostly visible at the species level, i.e. between varieties from S. dasycladosand S. viminalis, though smaller differences among varieties from the same species were also observed.
No significant effects of Salixvarieties were observed in the unfertilised plots, possibly due to the relatively high degree of spatial variability in several soil properties (pH, total N and total organic C contents).
Conclusion
This study provides evidence that the taxonomic distance, at the species level, among Salix plant varieties can affect the molecular composition and diversity of soil organic matter. Such an effect should be considered in breeding programmes for managing soil organic C, as it is one of the potential driver of organic C persistence in soils.
Evaluation and comparison of the performance of two reanalysis and satellite climatological databases under data scarcity conditions
Authors: Hessari Behzad , Farahmand Ghasem , Jahangiri Faezeh 
Published: April 2024

Abstract
The present study aimed to evaluate the performance of CHIRPS and ERA5 reanalysis and satellite data from 2011 to 2020. This evaluation was carried out using 8 synoptic stations and 23 rainfall gauge stations within the Aras River basin, spanning four countries. The results indicated that the daily correlation coefficient for minimum and maximum daily temperature parameters in the ERA5 database exceeded 0.9 for all stations. This value improved for monthly and seasonal scales, with these coefficients reaching approximately 0.99. In terms of precipitation, the comparison between CHIRPS and ERA5 databases revealed that ERA5 exhibited higher accuracy in estimating precipitation with an RMSD coefficient below 0.3. This trend was consistent at monthly and seasonal time scales. At the basin level, the analysis demonstrated that ERA5 had significantly higher accuracy compared to point-based data, as confirmed by the obtained statistical coefficients. Therefore, ERA5 products, particularly at monthly scales or at the basin level, can serve as suitable alternatives for data-scarce regions, especially in the Aras River basin.
Effect of Metronidazole on Concentrations of Vaginal Bacteria Associated with Risk of HIV Acquisition
Authors: Valint Daniel , Fiedler Tina , Liu Congzhou , Sriniva Sujatha , Fredricks David 
Published: April 2024

Abstract
Several bacterial vaginosis (BV)-associated bacteria have been associated with elevated risk of HIV acquisition, however susceptibility of these bacteria to antibiotics is poorly understood. Vaginal samples were collected from 22 persons daily for two weeks following BV diagnosis. Metronidazole treatment was prescribed for 5-7 days. Changes in bacterial concentrations were measured with taxon-specific 16S rRNA gene quantitative PCR (qPCR) assays. A culture-based antimicrobial assay confirmed presence of antibiotics in vaginal swab samples. Bacterial DNA concentrations decreased during antibiotic administration for all thirteen bacterial taxa tested. Comparison of bacterial DNA concentrations in samples before administration of antibiotics to samples taken on the last day of antimicrobial assay-confirmed antibiotic presence showed a 2.3-4.5 log10-fold decrease across all taxa. Concentrations were frequently reduced to the qPCR assay’s limit of detection, suggesting eradication of bacteria. Mean clearance time varied across taxa (1.2-8.6 days), with several bacteria (e.g., Gemella asaccharolytica, Sneathia spp., Eggerthella-like sp.) taking >7 days to suppress. Metronidazole reduces quantities of bacterial taxa associated with increased HIV acquisition risk. Eradication of high-risk vaginal bacteria using metronidazole is one promising avenue for reducing HIV acquisition risk. A 5–7-day treatment course may not be sufficient to suppress all bacteria.
Swelling properties of sand-fixing materials prepared with acrylic acid/acrylamide copolymer and palygorskite
Authors: Ren Hanru , Ren Jun , Tao Ling , Ren Xuechang 
Published: April 2024

Abstract
The sand-fixing materials were synthesized by crosslinking acrylic acid/acrylamide copolymer (AA/AM) and heat-modified palygorskite, and initiating the reaction with potassium persulfate (KPS) for investigating water absorbency. It was done to determine how certain characteristics, such as the palygorskite content, pH conditions and ultrasonic treatments, affected the Swelling properties of the sand-fixing materials. The results confirmed that the water absorbency for both distilled water and saline solution was improved by the addition of palygorskite, and the maximum swelling was attained when the palygorskite addition was 10%, however, as the clay amount was increased further to 15%, the swelling capacity decreased. Larger water absorbency was found for neutral water vs. alkaline water in the lower pH value. The ultrasonic treatments during the polymerization enhanced the water absorbency and retention of the sand-fixing materials with the ultrasonic power at 300W providing the maximum effectiveness.
Assessing the impact of altering temperatures on food consumption and nutritional indices of P. gossypiella in Bt cotton
Authors: Harshavardhan P. , Kaur Amandeep , Kumar Vijay 
Published: April 2024

Abstract

The study on ‘Influence of temperature on food consumption and nutritional indices of pink bollworm in Bt cotton’ was studied at various alternate temperatures (20:30, 24:30, 28:30, 20:35, 24:35, 28:35, 20:40, 24:40 and 28:40oC) in Integrated Pest Management Laboratory, Department of Entomology, PAU, Ludhiana during 2022-23 cotton growing season. The experiment was conducted on the second, third and fourth larval instars of pink bollworm and the results revealed that the maximum amount of food consumed was recorded at the temperature combination of 28:35oC for all the larval instars. The nutritional indices like Consumption index (CI), Relative Growth Rate (RGR), Approximate digestibility (AD) and Efficiency of conversion of ingested food (ECI) of second, third and fourth larval instars shown highest values at altering temperature combination of 28:35oC. The food consumption increased from second to third larval instar and it gradually decreased from third instar to fourth instar.
Evident decrease in future European soil moisture in the Kiel Climate Model grand ensemble
Authors: St-Pierre Médéric , Latif Mojib , Kjellsson Joakim , Park Wonsun , Borchert Leonard 
Published: April 2024

Abstract
The focus of this study is the European soil moisture trends following an increase in atmospheric CO2 concentrations. A single model-grand ensemble of 100 members, where CO2 levels increase by 1% per year for 140 years with the Kiel Climate Model, is used. A strong soil drying over most of Central Europe and the Mediterranean region when CO2 is quadrupled is found, with virtually all of the ensemble members agreeing on the sign of the change. This strong loss in soil moisture over Europe is driven mainly by a reduction in precipitation and, to a lesser degree, an increase in evaporation. Results also suggest that the precipitation pattern changes are partly linked to the response of the storm track to CO2 increases. Such soil moisture changes could have far-reaching impacts on extreme weather and climate events such as droughts or heat waves, with important implications for climate adaptation.
Long-term settlement analysis of immersed tube tunnel in operation considering undisturbed clayey soil foundation
Authors: Kou Lei , Liang Huiyuan , Wen Xin , He Huan 
Published: April 2024

Abstract

The differential settlements occur in the operation of immersed tube tunnel in clayey foundation, which will cause serious problems such as tube sections cracking and leakage that threaten the operation safety of immersed tube tunnel. The settlement of immersed tube tunnel is essentially caused by the change of underwater undisturbed soil properties caused by tunnel construction disturbance and the significant time-space characteristics of soil deformation. Therefore, it is necessary to accurately quantify the influence and development law of long-term uneven settlement of immersed tube tunnel by time-spatial characteristics. A rate-dependent elastic-viscoplastic constitutive model of clayey soil considering k0 consolidation is proposed, which is programmed into FLAC3D. Then, several years of the settlement monitoring data of an immersed tube tunnel is analyzed, and the long-term settlement of the immersed tube tunnel in operation is calculated and predicted by FLAC3D. The results show that the settlement rate of immersed tube tunnel has been maintained at about 0.0015 mm/d, and the settlement tends to converge to steady state. Timely dredging and reasonable foundation treatment methods are conducive to reducing settlement during operation. The results provide a theoretical for optimizing the design of immersed tube tunnel and ensuring the safety of tunnel operation.
Hydrogen Addition Effects on Flashback in a Combustion Chamber
Authors: Mohamadi Mehdi , Tahsini Amir Mahdi , Tavazohi Reyhaneh 
Published: April 2024

Abstract
The purpose of this work is to investigate the effects of adding hydrogen to the fuel on the combustion induced vortex breakdown flashback phenomenon in a combustion chamber. An atmospheric research burner is selected for studies and the analysis is performed using numerical simulations. In order to model the turbulence-chemistry interactions, the EDC combustion model is utilized and the GRI 2.11 reaction mechanism is used to investigate the combustion process as carefully as possible. The present studies are performed keeping the exit temperature constant. To do this, by adding any amount of hydrogen to the premixed inlet flow, the methane is decreased by using the trial-and-error until the mass averaged exit temperature remains almost constant. The purpose of applying this limitation is to keep the cycle operational condition unchanged that is important for adding hydrogen to the existing combustion chambers especially from technological viewpoint. In addition, the thermal NOx production is controlled. In the following, the effect of hydrogen addition on the flame thickness and flame shape is investigated and finally, the effect of operating pressure on the flashback behavior is analyzed.