bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of intravenous versus intraatrial administration of doxorubicin on the function and structure of the heart
Authors: Edington Howard , Mayer Deborah , Au Francis C. , Elfenbein I. Bruce , Bove Alfred A. , Smalley Richard V. 
Published: February 2007

AbstractTo evaluate the relationship of toxicity of doxorubicin to route of administration, we studied 21 mongrel dogs which were randomly assigned to one of three groups: 1) a control group undergoing intraatrial indwelling catheter placement but no drug therapy; 2) an IV group receiving weekly doxorubicin by peripheral IV bolus administration; and 3) a catheter group receiving weekly doxorubicin through an indwelling intraatrial catheter. After 8 weeks all dogs were evaluated hemodynamically and then sacrificed. Sections of right ventricle were evaluated by light and electron microscopy. Although no hemodynamic alterations were found in any of the three groups, significant ultrastructural damage consistent with doxorubicin cardiac toxicity was demonstrable in four of the six evaluable catheter dogs receiving intraatrial doxorubicin, but in none of the other 13 dogs evaluated. This finding suggests that the intraatrial administration of doxorubicin may lead to cardiac toxicity at a lower cumulative dose than noted with peripheral IV administration.
The effect of immunity on pulmonary metastasis of a methylcholanthrene‐induced fibrosarcoma and three of its clones
Authors: Yu Samuel , Wang Nancy , McKhann Charles F. 
Published: February 2007

AbstractA 3‐Methylcholanthrene (MC)‐induced fibrosarcoma and three of its clones were investigated for their metastatic potential in normal and tumor immune mice. The growth rates of the four tumors in vivo were similar. However, the mean survival times of the tumor‐bearing mice were markedly different. Clone 10, the most immunogenic, showed very high metastatic potential and short survival, while clone 27, the least immunogenic, produced few metastases, resulting in much longer survival. Moderate numbers of metastases were produced by highly immunogenic 3‐AM (parental tumor), and poorly immunogenic clone 34. Spleen cells from mice bearing highly immunogenic tumors lost their ability to neutralize tumors by day 28 after tumor inoculation, while those from mice bearing poorly immunogenic tumors remained cytotoxic, indicating that highly immunogenic tumors also induced immune suppression in the hosts. Immunization with specific tumors decreased the number of pulmonary metastases by 3 to 35‐fold. Immunization with tumors that shared antigens provided protection against metastatic tumors as well as the local tumors. In contrast, immunization with antigenically different tumors gave no protection.
Benign cysts of the parotid gland
Authors: Cohen Mimis N. , Rao Uma , Shedd Donald P. 
Published: February 2007

AbstractBenign cysts of the parotid gland are rare. They present with equal distribution between males and females as unilateral painless swelling in the area of the parotid gland without fixation to the overlying skin or involvement of the facial nerve. These cysts can be congenital, acquired, or occasionally may arise from surrounding structures.The preoperative diagnosis is very difficult and the treatment of choice consists of superficial parotidectomy. Our 10‐year experience with benign cyst of the parotid gland at Roswell Park Memorial Institute is presented in this paper.
Delayed cutaneous hypersensitivity, lymphocyte count, and blood tests in patients with breast carcinoma
Authors: Lee Yeu‐Tsu N.(Margaret) 
Published: February 2007

AbstractGeneral immunocompetence was examined in 125 patients with various stages of breast cancer. Tests include peripheral blood lymphocyte count, serum protein electrophoresis, quantitative immunoglobulins, CEA level, and delayed cutaneous hypersensitivity (DCH) reaction to six recall antigens (PPD, Monilia, mumps, Varidase, histoplasmin, and coccidioidin). About one third of the patients responded positively to each of the first four antigens, whereas 12% reacted to histoplasmin and 4% to coccidioidin. In this study, DCH to recall antigens had no prognostic value because the distributions of skin test reactivity were similar among patients with different stages of breast carcinoma. And among patients with similar stage of disease the relapse rates were similar for those who reacted and those who were anergic. But peripheral lymphocyte count had definite prognostic value because patients with advanced stage (group III/IV) and those who were anergic had significantly lower lymphocyte counts. Among patients with relatively early stages of breast carcinoma (group I/II), those who had higher lymphocyte count (≧ 2,000/mm3) had lower chance of having relapse up to 5 years after mastectomy.
Embolization of the liver in the management of metastatic carcinoid tumors
Authors: Mårtensson Hans , Nobin Anders , Bengmark Stig , Lunderquist Anders , Owman Torben , Sandén Göran 
Published: February 2007

AbstractEight patients with metastatic carcinoid tumors and the carcinoid syndrome were treated with gelatin foam embolization of the hepatic arterial tree. The aims were to reduce the tumor mass in the liver and to eliminate the carcinoid syndrome. The effects of the treatment were judged from arteriograms, CT scans, and the levels of serotonin in blood and 5‐HIAA in urine, as well as from the clinical symptoms. The mean follow‐up time was 12.5 months. In all patients the liver tumor mass was reduced after embolization, and this reduction persisted for at least 6 months in seven patients. After treatment, reduced serotonin levels in blood were measured in four patients and reduced 5‐HIAA levels in urine in seven patients. In five patients the carcinoid syndrome disappeared after embolization, but after 6 months two of these five patients had regained symptoms. Adverse reactions were minor consisting of a slight fever, reversibly increased serum levels of liver enzymes, and abdominal pain. In our experience, the hepatic embolization is a simple and safe method of giving relief from the carcinoid syndrome.
Long survival after ovarian and hepatic metastasis from carcinoma of the large bowel: Report of a case
Authors: Herrera‐Ornelas Lemuel , Sweeney Kevin , Petrelli Nicholas , Mittelman Arnold , Rao Uma , Prado‐Alcala Enrique 
Published: February 2007

AbstractHerein we present the case of a woman who is now 19 years post abdominoperineal resection for a Dukes' C1 rectal carcinoma, 10 years post right hemicolectomy for a Duke's C1 carcinoma of the ascending colon and removal of a solitary hepatic metastasis and now 9 years post resection of an ovarian metastasis. She had 5‐fluoracil, postoperatively. This is the ninth case reported in the literature of a 5‐year survivor free of disease following oophorectomy for metastatic adenocarcinoma of the large bowel. The finding of ovarian and hepatic metastases from her colorectal carcinoma would have indicated a poor prognosis. We feel that those rare patients who have an unexpected long survival should be reported for accumulation of clinical data, illustration of their clinical management, and analyses of the applied therapeutic interventions.
Recurrences after irradiation in early vocal cord cancer with literature review
Authors: Jose B. , Calhoun David L. , Mohammed Alyas 
Published: February 2007

AbstractRadiation therapy in early glottic cancer offers an excellent cure rate with preservation of voice. This study is an analysis of 25 (18%) patients who had failures after irradiation. Ten patients were in stage I (T1N0M0) and 15 patients in stage II (T2N0M0). All patients received megavoltage irradiation with an average dose of 6600 rad, 180 to 200 rad per day, 5 days in a week. Of the failures, 15 patients had the tumor controlled by salvage surgery, laryngectomy being the most common surgical procedure. The median time to recurrence was 23 months. A detailed analysis of the failures, along with a literature review, is done in this paper.
Cholesterol, weight, height, quetelet's index, and colon cancer recurrence
Authors: Tartter Paul I. , Slater Gary , Papatestas Angelos E. , Aufses Arthur H. 
Published: February 2007

AbstractThe association of low serum cholesterol with colon cancer mortality suggests that low serum cholesterol promotes colon cancer recurrence. We compared cumulative 5‐year recurrence‐free rates of 279 colon cancer patients in relation to serum cholesterol, weight, height, and Quetelet's index. The median value for each variable was used to divide patients into those above the median, or at the median and below. Patients with median and lower serum cholesterol exhibited an 11% lower disease‐free rate at 5 years. Patients above median weight were at significantly increased risk of recurrence in both sexes (76 vs 54%, z = 3.0026, p = 0.003). Progressively decreasing weight was noted with advancing stage in males but not in females. Women above median Quetelet's index were also at significantly greater risk of recurrence (74 vs 52%, z = 2.6109, p = 0.009). Patients above median height were at insignificantly increased risk of recurrence. This study indicates that body weight is a significant prognostic factor for patients with colon cancer.
Bilateral intrathyroidal hyperplastic parathyroid glands
Authors: Davis Orrin , Scanlon Edward F. , Pollak Elizabeth R. , Casey Joseph J. , Victor Thomas A. 
Published: February 2007

AbstractA patient with secondary hyperparathyroidism was found to have two intrathyroidal parathyroid glands. Parathyroid glands are found completely within the substance of the thyroid in approximately 2 to 8% of all cases. The surgical approach to hyperparathyroidism is discussed.
Cavernous hemangioma of the anus
Authors: Sweeney Kevin , Petrelli Nicholas , Herrera Lemuel , Lopez Cecilia , Mittelman Arnold 
Published: February 2007

AbstractVascular tumors of the large bowel can be divided into malignant and benign lesions. The benign lesions can be divided into capillary and cavernous hemangiomas. Large‐bowel hemangiomas are rere lesions, with the majority of cases reported in the rectum and rectosigmoid regions. Few cases of isolated anal hemangiomas are found in the literature. A case of an asymptomatic anal cavernous hemangioma, palpable on routine rectal examination and subsequently removed at proctosigmoidoscopy, is described.
Clear cell ovarian adenocarcinoma
Authors: Yoonessi Mahmood , Weldon Facog, David , Satchidand Sateesh K. , Crickard Kent 
Published: February 2007

AbstractA retrospective analysis of the clinico‐pathologic aspects of 22 cases of clear cell ovarian carcinoma with a literature survey is the subject of this report. The rarity of these neoplasms below the age of 40 is reaffirmed. Tumor‐related hypercalcemia was observed in two patients and postoperative thromboembolic complications were encountered in three others. Electron microscopic examination revealed abundant cytoplasmic glycogen content in two cases. Ten patients in this group and 26% in reported series had coexistent endometriosis. Association with endometrial carcinoma was observed in two patients and was reported in 14% of the cases. No patient of ours with Stage III or IV disease survived 5 years or longer and only 8% have reportedly survived in collective series. There was suggestive evidence of radiation tumor response in two patients with Stage IIC disease who had received 5,000 rads pelvic radiotherapy. Objective partial responses were also observed with adriamycin‐, cytoxan‐, and cis‐platinum‐containing combinations. A management plan is outlined.
Immunological status of trophoblastic neoplasia
Authors: Khanna A. , Khanna S. , Gupta R. M. , Gupta S. , Khanna A. K. 
Published: February 2007

AbstractSix cases of choriocarcinoma, 17 of vesicular mole, 20 normal pregnant females in the first trimester of pregnancy, and 20 normal nonpregnant women with previous normal obstetrical history were evaluated quantitatively for cell‐mediated immunity by response to 2:4 dinitrocholoroben‐zene and recall antigens. Serum immunoglobulins were estimated in all cases. Suppression of cell‐mediated immunity was marked in choriocarcinoma as compared to vesicular mole. Serum IgG levels were significantly diminished in cases of vesicular mole, indicating diminished humoral immunity. Follow‐up after 3 months of treatment with surgery and chemotherapy resulted in marked improvement of cell‐mediated immunity.
Primary lymphoma of meckle diverticulum: A case report
Authors: Al‐Dabbagh A. I. , Salih S. A. R. 
Published: February 2007

AbstractA case of a primary lymphoma of Meckle diverticulum in a 6‐year‐old Iraqi boy presenting clinically as acute appendicitis is reported. Exploration revealed a ruptured gangrenous Meckle diverticulum with an ileo‐ileal intussusception at the diverticulum origin. A fairly comprehensive search through the English language literature has failed to reveal any other report of a primary lymphoma of Meckle diverticulum leading to acute intestinal obstruction.
Myoepitheliomas of the head and neck: Case report and review
Authors: Barnes Leon , Appel Billy N. , Perez Horacio , Moneim El‐Attar A. 
Published: February 2007

AbstractThe clinical, light, and ultrastructural features of a myoepithelioma occurring on the hard palate of a 24‐year‐old woman are presented and compared with 41 myoepitheliomas of the head and neck described in the English literature. These 42 tumors (39 benign and 3 malignant) occurred in individuals from 14 to 81 years of age, affected both sexes about equally, and most often presented as a slowly enlarging, asymptomatic mass. The parotid gland and palate were the most common sites of occurrence. The tumors are typically circumscribed and encapsulated, vary from 1 to 5 cm in the greatest dimension, and are composed of spindled and/or plasmacytoid myoepithelial cells. Prognosis correlates with histologic appearance and parallels that of the pleomorphic adenoma. Conservative excision with a margin of uninvolved tissue is curative. The differential diagnosis and histogenetic relationship with other closely related neoplasms are discussed.
Primary carcinoma of the gall bladder: A review of a 16‐year period at the university hospital
Authors: Shukla V. K. , Khandelwal C. , Roy S. K. , Vaidya M. P. 
Published: February 2007

AbstractA review of the most relevant clinical data of patients with primary carcinoma of the gall bladder referred to our hospital over a 16‐year‐period has indicated that this is the third most common and aggressive cancer of the gastrointestinal tract. The disease occurs predominantly in elderly females who often present with extremes of clinical symptoms indicating benign biliary disease on the one hand and incurable malignant disease on the other. Laboratory and roentgenographic data tend to confirm the clinical diagnosis of this almost entirely incurable disease. The overall 5‐year survival of the patients with primary carcinoma of the gall bladder is less than 1%; a majority of the patients are dead in less than 6 months.
Recurrence rate of positive margin basal cell carcinoma: Results of a five‐year prospective study
Authors: De Silva Stephen P. , Lee Dellon A. 
Published: February 2007

AbstractThe few previous studies on recurrence of incompletely excised basal cell carcinoma are retrospective, and the reported recurrence rate ranges from 19% to 67%. In a prospective study design, we found a recurrence rate of 41% in 34 surgically excised positive‐margin basal cell carcinomas. The mean time until tumor recurrence was 24.6 months. The mean follow‐up time in those patients remaining free of tumor was 61.4 months.
Breast carcinoma at the extremes of age: A comparison of patients younger than 35 years and older than 75 years
Authors: Rosen Paul Peter , Lesser Martin L. , Kinne David W. 
Published: February 2007

AbstractWe assessed the prognosis of patients with breast carcinoma at the extremes of the age distribution of the disease. The groups examined were 166 women 35 years or less and 169 at least 75 years old. Analysis of recurrence and survival showed no significant difference between the groups as a whole or when they were stratified by nodal status. Life expectancy of elderly women with breast carcinoma was significantly reduced when compared with a “normal” age‐matched population. Medullary carcinoma was more frequent in young women while a relatively higher proportion of colloid and invasive lobular carcinoma occurred in elderly women. Bilateral carcinoma was found with nearly equal frequency in both age groups. However, elderly women were more likely to have been treated previously for contralateral carcinoma while young women tended to develop asynchronous, subsequent carcinoma.
Trends in the management of breast cancer
Authors: Raina Suresh , Rush Benjamin F. , Blackwood James M. , Lazaro Eric J. 
Published: February 2007

AbstractResponses of general surgeons to a questionnaire on breast cancer were analyzed to determine the current trends in the management of this disease. A 21‐item questionnaire was mailed to members of the New Jersey Chapter of the American College of Surgeons in 1982 and the responses, received on noncoded, anonymous answer sheets, were analyzed for frequency distribution. These responses were compared to previously recorded responses to the same questions for 1971 and 1977.Seventy‐six percent of the respondents in 1982 performed needle aspirations often or always, compared to 36% in 1971 and 80% in 1977. The use of routine mammography has increased from 16% in 1971 and 20% in 1977 to 38% in 1982. Modified radical mastectomy is now the most common type of procedure employed in the management of stage I breast cancer, with 89% of respondents in favor of this approach compared to 15% in 1971 and 60% in 1977. Fifty‐nine percent of the respondents are not opposed to breast reconstruction following mastectomy versus 14% in 1971 and 49% in 1977. For patients with axillary nodes, chemotherapy with multiple agents was recommended by 76% of general surgeons in 1982, compared to 58% in 1977.These results indicate a continuing trend towards increasing use of needle aspiration and routine mammography for diagnosis and for employment of chemotherapy with multiple agents in the adjuvant treatment of patients with positive axillary nodes. Furthermore, modified radical mastectomy is the operation of choice for stage I cancer of the breast for increasing numbers of surgeons.
An enzymatic method for the consistent production of monodispersed viable cell suspensions from human solid tumors
Authors: Rong Guo Huang , Grimm Elizabeth A. , Sindelar William F. 
Published: February 2007

AbstractAn enzymatic method is described for disaggregation of viable tumor cells from human solid tumors. The enzymatic cocktail consists of 0.1 % collagenase, 0.01% hyaluronidase, and 0.002% deoxyribonuclease. After mechanical mincing of the tumor tissue, tumor specimens are dissociated by incubation in the enzymatic cocktail for 12–18 hours at room temperature. In 17 cases of sarcoma, the mean yield was 5 × 106 viable cells per gram tumor tissue. Yield was 1 × 107 viable cells per gram tumor tissue in 23 cases of gastrointestinal carcinoma. The viabilities of tumor cell suspensions ranged from 50 to 98%, except for low viabilities in four specimens that were grossly composed almost entirely of necrotic tissue. The dissociation procedure is simple and the viable cell yield is sufficient for applications in studies of human cancer immunobiology.
Adjuvant corynebacterium parvum immunotherapy for squamous cell epitheliomas of the oral cavity, pharynx, and larynx
Authors: Neifeld James P. , Terz Jose J. , Kaplan Alan M. , Lawrence Walter 
Published: February 2007

AbstractPatients with primary squamous cell epitheliomas of the oral cavity, pharynx, and larynx were stratified according to stage and site and randomized to receive either intratumoral immunotherapy with Corynebacterium parvum followed 2 weeks later by surgery and postoperative C parvum for 2 years or surgery alone. There were 209 patients entered into the trial and 176 were fully evaluable. All prognostic variables were similar between the two groups. There was no difference in disease‐free survival or absolute survival between the two groups of patients. In addition, there was no difference noted for any stage and/or site. The only difference in sequential immunologic testing was that chemokinesis was increased following intratumoral C parvum, but neither this nor any other immunologic test correlated with ultimate recurrence or survival. These data demonstrate that immunotherapy using preoperative, intralesional C parvum and postoperative, subcutaneous C parvum is ineffective when used as an adjuvant to surgery for primary cancers arising in the oral cavity, pharynx, and larynx.
Surgical intervention of countless metastatic lung lesions: A case report
Authors: Zylstra Samuel , Karakousis Constantine , Takita Hiroshi 
Published: February 2007

AbstractA patient with countless metastatic bilateral lung lesions from sarcoma of an extremity was treated surgically. The patient is alive in good physical condition nearly 2 years following the surgery. Although there are residual pulmonary metastases, they appear to be stational. Surgical intervention of countless metastatic lung lesions may be indicated in selected cases.
Castleman's tumor with retroperitoneal location: A malignant‐appearing benign tumor
Authors: Skolnik Gabor , Wiklund Lars‐Martin , Risberg Bo 
Published: February 2007

AbstractA case of a large retroperitoneal tumor in the pararenal region is presented. The tumor had an initial appearance of a malignant neoplasm both radiographically and at operation but histopathologically it turned out to be a rare benign tumor, Castleman's disease. Based on the benign nature of this lymphoid tumor extensive surgical procedures should be avoided as limited excision of the tumor appears to have been curative in all the patients reported in the literature.
Detection of recurrent cancer of the colon and rectum
Authors: Graffner Hans , Hultberg Bjöurn , Johansson Bengt , Müller Torgil , Petersson B. G. 
Published: February 2007

AbstractOutpatient follow‐up in patients operated upon due to carcinoma of the colon and rectum is usually performed, due to a high rate of recurrence and with the aim of finding a curable recurrence. Due to the enormous cost of an extended follow‐up system, a careful evaluation of the benefit is needed. The aim of the present investigation was to study the efficacy of the different tools in an extended follow‐up. One hundred ninety patients with carcinoma of the colon and rectum were—apart from traditional clinical follow‐up‐followed with an extensive laboratory battery including carcinoembryonic antigen (CEA), erythrocyte sedimentation rate (ESR), hemoglobin (Hb), electrophoresis, ALP, and GT. Forty‐seven recurrences were found. Thirty‐one of these recurrences were first detected by a rise in CEA. Seven cases were detected at clinical follow‐up and six cases due to symptoms suggestive of recurrence. The predictive value of a positive test was 79.4% for CEA but very low for the other tests studied. A negative value for any of the tests in the battery was usually accurate. Follow‐up after colorectal carcinoma should include CEA as the only laboratory parameter. Postoperative colonoscopy for removal of missed synchronous lesions, chest X‐ray, and endoscopic investigations of the anastomotic region also seem to be of value.