bluuebunny/crossref_metadata_2025_split huggingface dataset:
Methanol extract of Ligusticum chuanxiong Hort. Rhizome ameliorates bilateral common carotid artery stenosis-induced cognitive deficit in mice by altering microglia and astrocyte activation
Authors: Lim Sehyun , Lim Chiyeon , Cho Suin 
Published: March 2024

In traditional Asian medicine, Ligusticum chuanxiong Hort also known as Conioselinum anthriscoides “Chuanxiong”, is mainly used for improving blood circulation or for analgesic and anti-inflammatory purposes, but they also have a long history of use for pain disorders in the head and face, such as headache. Despite the possibility that the plant is effective for diseases such as cerebral infarction and vascular dementia (VaD), the mechanism of action is not well understood. To determine if the dried rhizomes of L. chuanxiong (Chuanxiong Rhizoma, CR) methanol extract (CRex) has activity in a VaD mice model. Through network analysis, we confirm that CR is effective in cerebrovascular diseases. In mice, we induce cognitive impairment, similar to VaD in humans, by chronically reducing the cerebral blood flow by performing bilateral common carotid artery stenosis (BCAS) and administering CRex for 6 weeks. We measure behavioral changes due to cognitive function impairment and use immunofluorescence staining to confirm if CRex can inhibit the activation of astrocytes and microglia involved in the inflammatory response in the brain. We quantify proteins involved in the mechanism, such as mitogen-activated protein kinases (MAPK), in the hippocampus and surrounding white matter, and analyze gene expression and protein interaction networks through RNA sequencing to interpret the results of the study. CRex administration rescued cognitive impairment relating to a novel object and inhibited the activation of astrocytes and microglia. Western blotting analysis revealed that CRex regulated the changes in protein expression involved in MAPK signaling such as extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinase (p38). The administration of CRex suppressed approximately 44% of the pathological changes in gene expression caused by BCAS. CRex extract effectively inhibited cognitive impairment caused by BCAS, and the mechanism through which this occurred is inhibited activation of astrocytes and microglia.
CHF6297: a novel potent and selective p38 MAPK inhibitor with robust anti-inflammatory activity and suitable for inhaled pulmonary administration as dry powder
Authors: Martucci Cataldo , Allen Andrew Dennis , Moretto Nadia , Bagnacani Valentina , Fioni Alessandro , Patacchini Riccardo , Civelli Maurizio , Villetti Gino , Facchinetti Fabrizio 
Published: March 2024

Inhibition of p38 mitogen-activated protein kinase (MAPKs) is a potential therapeutic approach for the treatment of acute and chronic pulmonary inflammatory conditions. Here, we report the in vitro and in vivo characterization of the anti-inflammatory effects of CHF6297, a novel potent and selective p38α inhibitor designed for inhalation delivery as a dry powder formulation. CHF6297 has been proven to inhibit p38α enzymatic activity with sub-nanomolar potency (IC50 = 0.14 ± 0.06 nM), with &gt;1,000-fold selectivity against p38γ and p38δ. In human peripheral blood mononuclear cells (PBMCs) stimulated with lipopolysaccharides (LPS), as well as in human bronchial epithelial cells (BEAS2B) stimulated with TNF-α or cigarette smoke extract (CSE), CHF6297 inhibited interleukin (IL)-8 release with low nanomolar potency. CHF6297 administered to rats by using a nose-only inhalation device as a micronized dry powder formulation blended with lactose dose-dependently inhibited the LPS-induced neutrophil influx in the bronchoalveolar lavage fluid (BALF). CHF6297 administered intratracheally to rats dose-dependently counteracted the IL-1β (0.3 mg/kg)-induced neutrophil influx (ED50 = 0.22 mg/kg) and increase in IL-6 levels (ED50 = 0.82 mg/kg) in the BALF. In mice exposed to tobacco smoke (TS), CHF6297, administered intranasally (i.n.) for 4 days at 0.03 or 0.3 mg/kg, dose-dependently inhibited the corticosteroid-resistant TS-induced neutrophil influx in the BALF. In a murine house dust mite (HDM) model of asthma exacerbated by influenza virus A (IAV) (H3N3), CHF6297 (0.1 mg/kg, i.n.) significantly decreased airway neutrophilia compared to vehicle-treated IAV/HDM-challenged mice. When CHF6297, at a dose ineffective per se (0.03 mg/kg), was added to budesonide, it augmented the anti-inflammatory effects of the steroid. Overall, CHF6297 effectively counteracted lung inflammation in experimental models where corticosteroids exhibit limited anti-inflammatory activity, suggesting a potential for the treatment of acute exacerbations associated with chronic obstructive pulmonary disease (COPD) and asthma, acute lung injury (ALI), and viral-induced hyperinflammation.
Effects of the epiphytic patterns on endophytes and metabolites of Dendrobium nobile Lindl
Authors: Yu Chengxin , Wang Peng , Ding Haiyan , Hu Yuan , Wang Fu , Chen Hongping , Chen Lin , Liu Youping 
Published: March 2024

IntroductionDendrobium is an epiphytic herb plant with neuroprotective, gastroprotective, anti-inflammatory, and immunomodulatory effects. It is often found attached to tree trunks or rocks. With the development of the dendrobium industry, numerous epiphytic patterns exist, such as crushed stone, stump, and sawdust. The study of metabolites and endophytes of D. nobile under different epiphytic patterns, which revealed the effects of epiphytic patterns on D. nobile from the perspectives of metabolomics and microbiology, is of great significance for the healthy development of D. nobile.MethodsIn the study, the D. nobile under five epiphytic patterns grown in the same environment were selected. The metabolites were investigated by widely targeted metabolomics, and the endophytes were sequenced using high-throughput sequencing methods. Then, a correlation analysis between the different metabolites and endophytes was performed.ResultsA total of 1,032 metabolites were annotated in D. nobile. There are more flavonoids and phenolic acids accumulated on the epiphytic pattern of Danxia stone, whereas the accumulation of lipids on the other epiphytic patterns and 16 differential metabolites was screened out. The endophyte composition of D. nobile was dominated by Proteobacteria, Actinomycetes, unidentified bacteria, Firmicutes, and Cyanobacteria. For endophytic fungi, Basidiomycota and Ascomycota were the dominant phyla of D. nobile. The relative abundance of Spirosoma, Nocardioides, and Arrhenia in the Danxia stone was significantly higher than that of other epiphytic patterns. According to correlation analysis, we found a significant correlation between differential metabolites and Spirosoma, Nocardioides, and Arrheni.DiscussionThis study confirmed that Dendrobium quality was affected by its epiphytic patterns and revealed its possible causes from a microbiological point of view.
The cost of “snubbing”: the effect of parental phubbing on filial piety behavior in children and adolescents
Authors: Zhang Yongxin , Chen Bingran , Ding Qian , Wei Hua 
Published: March 2024

BackgroundAlthough numerous studies have used Chinese samples to examine the consequences of parental phubbing, these studies focused on children’s mental health and peer interaction. No research to date has directly explored the association between parental phubbing and child–parent interaction. Since parental phubbing is a way how parents interact with their children (parent–child), it might be associated with the way how children interact with their parents (child–parent), such as filial piety behavior, which prescribes how children behave toward their parents and remains one of the goals of parents in educating their children in modern Chinese society. Based on social exchange theory and social gender theory, this study investigated the impact of parental phubbing on filial piety behavior and tested its mediation of perceived parental rejection, its moderation of gender among children and adolescents.MethodsThis study was conducted using a questionnaire method. A total of 753 students from Grade 4 to 9 (Mage = 12.28 years, SD = 1.81 years) was surveyed using the Parental Phubbing Scale, Perceived Parental Rejection Questionnaire, and the revised Dual Filial Piety Scale.ResultsFirst, parental phubbing was negatively correlated with reciprocal filial piety (RFP) behavior, but not correlated with authoritarian filial piety (AFP) behavior. Second, perceived parental rejection played a mediating role between parental phubbing and RFP behavior. Third, this direct effect was moderated by gender, in that it was stronger for boys than for girls.ConclusionThese findings suggest that there are intergenerational costs of phubbing, such as reducing children and adolescents’ RFP behavior. The present study is the first to combine parent–child interaction in the digital media era (parental phubbing) with traditional Chinese child–parent interaction (RFP behavior), which expands the research topic on the influence of parental phubbing on children and adolescents’ psychological development.
External focus instruction using a paper balloon: impact on trunk and lower extremity muscle activity in isometric single-leg stance for healthy males
Authors: Murofushi Koji , Morito Tsuyoshi , Akuzawa Hiroshi , Oshikawa Tomoki , Okubo Yu , Kaneoka Koji , Mitomo Sho , Yagishita Kazuyoshi 
Published: March 2024

IntroductionCore stability is crucial for preventing and rehabilitating lumbar spine injuries. An external focus instruction using a paper balloon is an effective way to activate the trunk muscles. However, the degree of trunk and lower extremity muscle activation during single leg stance with external focus instruction using a paper balloon is unknown. This study aimed to investigate the core muscle involving activity in the trunk and lower extremities on both the support and non-support sides with or without using external focus instruction using a paper balloon during isometric single-leg stance.MethodsThirteen healthy males aged 20–28 years volunteered to take part in this study and performed a single leg stance task with and without an external focus instruction, pressing their non-supporting foot onto a paper balloon without crushing it. The participant's muscle electrical activity was recorded during the single leg task using surface EMG and intramuscular EMG for six trunk muscles (transversus abdominis, internal oblique, external oblique, rectus abdominis, multifidus, and lumbar erector spinae) and five lower extremity muscles (gluteus maximus, gluteus medius, adductor longus, rectus femoris, and biceps femoris)ResultsCompared to the normal single leg stance, the external focus instruction task using a paper balloon showed significantly increased transversus abdominis (p &lt; 0.001, p &lt; 0.001), internal oblique (p = 0.001, p &lt; 0.001), external oblique (p = 0.002, p = 0.001), rectus abdominal (p &lt; 0.001, p &lt; 0.001), lumbar multifidus (p = 0.001, p &lt; 0.001), lumbar erector spinae (p &lt; 0.001, p = 0.001), adductor longus (p &lt; 0.001, p &lt; 0.001), rectus femoris (p &lt; 0.001, p &lt; 0.001), and biceps femoris (p &lt; 0.010, p &lt; 0.001) muscle activity on the support and non-support sides.ConclusionIn conclusion, external focus instruction using a paper balloon significantly activates the trunk and lower extremities muscles on both the support and non-support sides. This finding provides insights for designing programs to improve coordination and balance. The benefits extend to diverse individuals, encompassing athletes, tactical professionals, and the general population, mitigating the risk of injury or falls linked to inadequate lower limb balance.
Consumers’ purchase propensity for pasta tracked with blockchain technology and labelled with sustainable credence attributes
Authors: Petrontino Alessandro , Frem Michel , Fucilli Vincenzo , Tria Emanuela , Campobasso Adele Annarita , Bozzo Francesco 
Published: March 2024

IntroductionPasta is a key product in Italy’s agri-food industry, consumed due to its ease of preparation, nutritional richness, and cultural importance. Evolving consumer awareness has prompted adaptations in the pasta market, to address concerns about social, environmental, quality, and food safety issues. This study examines Italian consumers’ willingness to pay (WTP) for pasta in local markets, analysing their behaviours and preferences.MethodsFor this purpose, we used a discrete choice experiment (DCE) technique combined with a latent variable model. We also collected 397 valid online questionnaires.Results and DiscussionThe results reveal an interest utility among all respondents to pay a price premium of €1.16, €0.82, €0.62, €0.41, and €0.36 for 500 g of pasta, for the use of blockchain/QR code (BC) technology on the label, providing data on credence attributes such as safety, environmental and social sustainability as well as business innovative practices, respectively. As such, this research has private and public implications. On one hand, this research may bridge the scarcity in studies regarding consumer preferences and WTP for BC in the pasta value chain, preventing agricultural frauds, ensuring the sustainability and quality of agri-food products like pasta, and protecting and educating consumers through clear and transparent information. On the other hand, this research may incentivise pasta businesses to meet social and environmental consumers’ demands while simultaneously enhancing their financial performance.
Virological characteristics correlating with SARS-CoV-2 spike protein fusogenicity
Authors: Begum MST Monira , Ichihara Kimiko , Takahashi Otowa , Nasser Hesham , Jonathan Michael , Tokunaga Kenzo , Yoshida Isao , Nagashima Mami , Sadamasu Kenji , Yoshimura Kazuhisa ,   The Genotype to Phenotype Japan (G2P-Japan) Consortium, Sato Kei , Ikeda Terumasa 
Published: March 2024

IntroductionThe severe acute respiratory syndrome coronavirus (SARS-CoV-2) spike (S) protein is essential in mediating membrane fusion of the virus with the target cells. Several reports demonstrated that SARS-CoV-2 S protein fusogenicity is reportedly closely associated with the intrinsic pathogenicity of the virus determined using hamster models. However, the association between S protein fusogenicity and other virological parameters remains elusive.MethodsIn this study, we investigated the virological parameters (e.g., S1/S2 cleavage efficiency, plaque size, pseudoviral infectivity, pseudovirus entry efficiency, and viral replication kinetics) of eleven previous variants of concern (VOCs) and variants of interest (VOIs) correlating with S protein fusogenicity.Results and discussionS protein fusogenicity was found to be strongly correlated with S1/S2 cleavage efficiency and plaque size formed by clinical isolates. However, S protein fusogenicity was less associated with pseudoviral infectivity, pseudovirus entry efficiency, and viral replication kinetics. Taken together, our results suggest that S1/S2 cleavage efficiency and plaque size could be potential indicators to predict the intrinsic pathogenicity and S protein fusogenicity of newly emerged SARS-CoV-2 variants.
L’Allemagne de Jean Cavaillès (1903-1944) au début des années 30. Entre optimisme scientifique et désarroi religieux
Authors: Séguin Philippe 
Published: March 2024

L’Allemagne de Jean Cavaillès (1903-1944) au début des années 30 : entre optimisme scientifique et désarroi religieux.
Jean Cavaillès (1903-1944) se vit attribuer en 1930 une bourse Rockefeller d’un an pour étudier les mouvements de jeunesse en Allemagne. Mais il se détourna bien vite du travail sociologique pour se consacrer à des sujets qui lui tenaient davantage à cœur : la religion, puisqu’il était profondément croyant, et une réflexion sur la théorie des ensembles qui était son sujet de doctorat. S’il fut déçu sur le plan religieux à la fois par les protestants et les catholiques, son travail scientifique ne semble lui avoir apporté que des motifs de satisfaction. Le climat intellectuel et politique qui régnait alors à l’Institut mathématique de l’Université de Göttingen, où il travailla, ne fut pas sans contribuer à l’optimisme de Cavaillès sur le plan scientifique.
La langue et sa vision du monde. Attribution réciproque de stéréotypes. Une approche comparée du français et de l’allemand
Authors: Haßler Gerda 
Published: March 2024

Sprache und Weltanschauung in Frankreich und Deutschland : Sprachwissenschaft oder nationalistischer Diskurs ?
Das Problem der Beziehung zwischen einer Sprache und dem besonderen Denken des Volkes, das sie spricht, wird in Sprachtheorien diskutiert und stellt sich auch bei der Betrachtung des Sprachbewusstseins der Sprecher. In diesem Beitrag soll untersucht werden, wie deutsche Romanisten das Wesen der französischen Sprache ausgehend von den von ihnen untersuchten sprachlichen Erscheinungen interpretierten. Der nationalistische Diskurs über eine Sprache als Ausdruck der Gesamtheit des Lebens eines Volkes hat nur wenige äußere Gemeinsamkeiten mit der idealistischen Philologie. Dennoch war es in Deutschland schwierig geworden, ein kulturwissenschaftliches Herangehen an die Sprache von den Missbräuchen, denen diese Idee Vorschub geleistet hatte, zu trennen.
Les « chants du soldat » dans le folklore français
Authors: Delarue Georges 
Published: March 2024

Les chants de tradition orale constituant le folklore militaire proprement dit sont soit des chants à caractère bachique, soit des paillardes. Pourtant plusieurs folkloristes ont, dans l’ordonnancement de leur collecte, un chapitre intitulé « Chants de soldats» (ou avec un titre analogue). En réalité, les chants qu’ils y rangent se rapportent plutôt à la vie militaire vue par des civils. Si l’on cherche à analyser cet ensemble, à la manière dont je l’ai déjà fait pour présenter ce que l’on appelle couramment « les chants de métiers », on peut distinguer :
- les chants accompagnant les activités : paroles mises sur des sonneries de clairon ; chants rythmant la marche (les paillardes évoquées plus haut) ;
- les chants emblématiques (chantés par des civils à la veillée ou au cabaret ; ou bien braillés dans les rues par de futurs militaires) ; les « chants de parade » composés spécialement à la gloire de tel ou tel régiment n'appartiennent pas au folklore ; chants de conscrits (parmi lesquels les paillardes font fonction de « rite de passage » de l’adolescence à l’âge adulte) ; récits de combats ou de victoires (rarement de défaites) ;
- les chants contre-emblématiques (auto-dérision, moquerie venant des autres ou refus de la vie militaire) : soldats riboteurs ; soldats niais ; soldats en révolte ; les adieux du soldat ; déserteurs, retour au pays ;
- un genre particulier : « les filles-soldats », développe une thématique que l’on peut rattacher tantôt à l’une, tantôt à l’autre des deux catégories précédentes ;
- les chants de l’oubli (chantés lors des moments de repos ; leur thématique est le plus souvent sans rapport avec la vie militaire). Un exemple nivernais : chant de mariniers. Universalité : extrait d’un reportage du Monde sur la guerre en Irak.
Viribus Unitis pour l’œuvre du Prince Héritier. La Monarchie Austro-Hongroise par le texte et l’image
Authors: Zintzen Christiane 
Published: March 2024

L’encyclopédie La Monarchie austro-hongroise par le texte et l’image – couramment appelée l’Œuvre du Prince Héritier en l’honneur de son initiateur et éditeur, le prince héritier Rodolphe d’Autriche – constitue un apport particulièrement remarquable de l’Empire des Habsbourg dans le domaine du livre. Porteur d’idées assez libérales, le fils de l’empereur confia à plusieurs auteurs, scientifiques, journalistes et dessinateurs connus, la mission de décrire les pays et les peuples de la Monarchie Habsbourgeoise. La parution des 24 volumes de l’encyclopédie commença en 1886 pour s’achever en 1902 (elle a donc duré 16 ans). L’ambition de cet ouvrage n’était pas mince : il s’agissait ni plus ni moins de rendre compte, en quelque 600 articles agrémentés de plus de 4500 illustrations, de la diversité géographique, biologique, ethnique et culturelle de l’Empire Habsbourgeois.
Christiane Zintzen, germaniste et spécialiste d’histoire culturelle, a rassemblé dans un ouvrage les textes de cette encyclopédie les plus remarquables du point de vue actuel, offrant ainsi de précieux documents à tous ceux qui étudient l’histoire de l’Autriche – sans pour autant céder à la nostalgie de la période impériale. Dans sa contribution, l’auteur présente l’Œuvre du Prince Héritier et sa sélection d’articles.
Deutschland zwischen Heimat und Fremde. Victor Klemperers Tagebücher
Authors: Sepp Arvi 
Published: March 2024

L’Allemagne entre Heimat et pays étranger. L’identité judéo-allemande dans les Journaux intimes (1933-1945) de Victor Klemperer.
Cet article retrace l’évolution identitaire du romaniste judéo-allemand Victor Klemperer dans ses Journaux intimes du Troisième Reich. Ces Journaux lui permettent de s’affirmer face à l’humiliation nazie. Le nationalisme de Klemperer est progressivement remplacé par une identité multiple. Dans ce contexte, nous traiterons de concepts tels que Heimat, identité et patrie et démontrerons comment les Journaux intimes de Klemperer remettent en question l’assimilation judéo-allemande et l’identité nationale de l’auteur.
Lieder gegen „das Dunkel in den Köpfen“ und zum Schutz der Heimat. Zur Kultur der oberpfälzischen Bürgerinitiativen gegen die atomare Wiederaufarbeitung in Wackersdorf in den 1980er Jahren
Authors: Otto Uli 
Published: March 2024

Chants contre « la nuit dans les têtes » et pour la défense du pays. À propos de la culture des mouvements de citoyens du Haut-Palatinat mobilisés contre le projet d’usine de retraitement de déchets nucléaires à Wackersdorf dans les années 1980.
Cette contribution s’intéresse aux différentes formes culturelles de subjectivation dans les mouvements de citoyens mobilisés contre le projet d’une usine de retraitement de déchets nucléaires implantée à Wackersdorf, village du Haut-Palatinat, et se concentre plus particulièrement sur les musiciens allemands « folk » engagés, leur musique et leurs chansons, d’autant plus que ces dernières n’ont jamais été étudiées ni même érigées en champ de recherche par les ethnologues et les musicologues. Le projet d’usine de retraitement de déchets nucléaires fut abandonné en mai 1989, sept mois après la mort de son plus chaud partisan, le Premier ministre du Land de Bavière Franz Joseph Strauss.
A Study on Corporate Greenwashing on Manufacturing of Lithium Batteries of Electric Vehicle (EV)
Authors: Venkatesh Kumar R , Suresh C 
Published: March 2024

The emergence of electric vehicles (EVs) as a promising solution to environmental concerns has coincided with a troubling phenomenon—greenwashing. This paper explores the deceptive practices employed by some entities in the EV industry to exaggerate their environmental credentials. The primary objective is to shed light on the subtle manipulations and misleading marketing strategies that obscure the true ecological impact of EVs.
Examining case studies and industry trends, the paper delves into instances where companies emphasize the zero-emission aspect of EVs while overlooking the entire lifecycle's environmental toll, from raw material extraction to production and disposal. The allure of a greener alternative has led to a competitive landscape where distinguishing between authentic sustainability and superficial marketing becomes challenging for consumers.
Furthermore, the paper delves into the motivations behind greenwashing in the EV sector. It investigates how these practices serve as a market appeal strategy, attracting environmentally conscious consumers, and how they contribute to gaining a competitive edge in an increasingly saturated market. By identifying greenwashing, the paper advocates for consumer protection and encourages corporate accountability, emphasizing the importance of transparent and genuine commitment to sustainability in the rapidly evolving landscape of electric vehicles.