bluuebunny/crossref_metadata_2025_split huggingface dataset:
Finite Lab-Transform (FLT) for Invertible Functions in Cryptography
Authors: Lablans Peter 
Published: February 2024

This article introduces a novel number theoretical transformation: the Finite Lab-Transform or FLT, which preserves meta-properties of transformed functionality of 2-operand computer functions described over ℤn. Existing machine cryptography applies functions described as addition over Finite Field GF(n=2^k) applied in encryption such as AES-GCM and ChaCha20 and hashing as SHA-256, which are part of standard TLS 3.1. Usually as bitwise XOR of words of k bits. This functionality is modified by the FLT. Properties like involution, associativity and invertibility are preserved by the FLT. The FLT allows secret customization of existing and novel cryptographic primitives while maintaining proven data-flow. Improvement of security against brute force attacks with a factor greater than 10^400 can be achieved.
«V» бүркеншік есімімен жарияланған еңбектердің Əлихан Бөкейханға қатыстылығы туралы
Authors: Құрманбайұлы Ш. 
Published: February 2024

2016 жылы алаш ардақтысы Әлихан Бөкейханның 15 томдық шығармалар жинағының екінші басылымы жарық көрді. 15 томдық шығармалар жинағы тынымсыз еңбек пен көп ізденістің арқасында басылып шыққаны анық. Дегенмен көптомдықтағы кейбір мақала мен аудармалардың ұлт көсемі Ә.Бөкейханға тиесілі екен күмән, сұрақ тудыртады. Нақтырақ айтқанда кейбір бүркеншік есіммен жазылған еңбектерге ерекше назар аудару қажеттігі байқалады. Мәселен, соңына алашкөсемінің бүркеншік есімдерінің бірі деп есептеліп жүрген «V» әрпі (таңбасы) қойылған кейбір мақалалар мен аудармалар солардың қатарына жатады. Ә. Бөкейхандікі екені анық еңбектер мәтіні мен «V» бүркеншік есімі қойылған еңбектердің мәтінін лингвистикалық тұрғыдан салыстырасалғастыра зерттеу барысында олардың стилі мен сөз қолданысында елеулі өзгешеліктер бар екені анықталды. Мақалада Әлихан Бөкейханның 15 томдығындағы «V» бүркеншік есімімен тіркелгенмақалалардың алаш көсеміне тиесілі еместігі тілдік және тарихи деректер негізінде айқындалады. Аталған бүркеншік есім қойылған қазақ тіліндегі мақалалар алаш көсемі Ә. Бөкейханға емес, алғаш алашшылдар қатарында болып, кейін компартия қатарына өтіп, социалистік қоғамның орнығуына белсенді қызмет еткен белгілі кеңес қайраткері Молдағали Жолдыбайұлына тиесілі екендігі екі автордың мәтіндеріне қатар талдау жасау арқылы дәлелденеді. Бұл авторлардың саяси көзқарастарымен компартияның ұстанған саяси курсына, кеңестік идеологияға қатысты ұстанымдары да сәйкеспейтіні, бір арнаға тоғыспайтыны да олардың әр кезеңде жазған еңбектері негізінде нақты көрсетілді. Зерттеу негізінде «V» бүркеншік есімінің артында екі автор тұр деген тұжырым жасалып, қай еңбектің кімге тиесілі екені ажыратылып берілді.
Ethnobotany, chemistry and toxicity of Petivera alliacea: A review
Authors: Lawal Ibrahim Oduola , Sowunmi Linda Ifeanyichukwu , Olaniyi Musbau Bayonle , Jegede Adelola Esther , Akanni Funmilola Olamide , Akinwumi Idayat A. , Babalola Oyinkansade Yetunde 
Published: February 2024

Petivera alliacea (Family, Phytolaccaceae) is a wild and perennial shrub used in traditional medicine, especially as an antirheumatic, analgesic, and for various respiratory diseases. There is little comprehensive data on P. alliacea's pharmacological, nutritional, and ethnobotanical characteristics, and it is not in a well-documented form. In the present review, efforts have been made to gather its detailed medicinal uses, chemical composition, and pharmacological properties. The goal of this review is to present an updated summary of documents sourced from recent publications regarding the ethnobotanical importance, pharmacology, toxicological properties, and phytochemistry of P. alliacea to further investigate this plant and learn about its potential impact on pharmaceuticals. This literature review used web-based systematic research. PubMed, Google Scholar, Mendeley, and CriticalReview were used to find studies reporting pharmacological, nutritional, and pharmacological properties. The ethnobotanical uses of P. alliacea include the treatment of respiratory disorders, fever, venereal diseases, and influenza. The nutritional uses include the use of the powder as herbal concoctions in the form of extracts, teas, and capsules intentionally for boosting immune systems. The reported pharmacological activities are antimicrobial, anti-inflammatory, antidiabetic, anticancer, immunostimulating and antinociceptive activities. Along with flavonoids, steroids, and triterpenes, P. alliacea also has sulfur-containing compounds like sulfides, polysulfides, and sulfoxides that make it unique. This review provides detailed information about the history, traditional importance, phytochemistry, and clinical impacts of the studied plant as food and medicine.
Keywords: Petiveria alliacea, Traditional medicine, Pharmacological activities, Nutritional importance, Secondary metabolites
NOVA OCORRÊNCIA DE LIVONECA REDMANNI (ISOPODA: CYMOTHOIDAE) NO LITORAL NORDESTE DO BRASIL
Authors: Mota Alves André , Freitas Freire Janaína , Palmeira dos Santos Tatiana Maria , Madi Rubens Riscala 
Published: February 2024

Os registros de ocorrência de isópodes parasitas no litoral nordeste do Brasil têm aumentado nos últimos anos, entretanto as espécies ocorrentes e sua distribuição no litoral ainda não são totalmente conhecidas, o que faz com que registros de ocorrência sejam importantes para que monitoramentos futuros possam ser realizados com exatidão. Desta forma, esse estudo objetivou relatar uma nova ocorrência de Livoneca redmanni Leach, 1818 (Cymothoidae), trazendo uma descrição morfológica completa e abordando alguns aspectos de sua distribuição. Os peixes analisados no presente estudo foram adquiridos em pontos de venda e analisados em laboratório. Apenas dois peixes estavam parasitados com um isópode cada. A baixa prevalência indica que esse tipo de infestação pode estar relacionado à uma competição por recursos, gerando um fator que não permite a co-ocorrência de mais que dois espécimes do parasita por hospedeiro. As características morfológicas dos espécimes coletados estavam de acordo com as descrições presentes na literatura científica. Em conclusão, no presente estudo, é apresentada uma nova ocorrência no status biogeográfico de L. redmanii no litoral nordeste do Brasil, o estado de Sergipe, contribuído para o conhecimento da distribuição desse crustáceo no litoral brasileiro.
TARTARUGAS MARINHAS E FIBROPAPILOMATOSE: UM ESTUDO CIENCIOMÉTRICO NO BRASIL
Authors: Souza Azevedo Juliana , Nonato Guimarães Priscilla Aparecida 
Published: February 2024

A fibropapilomatose (FP) é uma doença viral que acomete tartarugas marinhas mundialmente, comprometendo suas funções vitais. Esta pesquisa objetivou realizar uma análise cienciométrica acerca dos estudos sobre tartarugas marinhas no Brasil, com foco na FP. Apesar de o Brasil estar na segunda posição mundial em relação aos estudos sobre FP em tartarugas marinhas, ainda se observa uma carência de publicações sobre essa enfermidade, que não é o foco central das pesquisas em quelônios marinhos, representando 16% da publicação mundial sobre o tema. Chelonia mydas é a espécie mais estudada sobre FP, com predomínio de estudos sobre o tema nos estados de São Paulo, Espírito Santo, Rio de Janeiro, Bahia e Ceará. Quando financiados, a maioria dos trabalhos recebeu financiamento nacional, e a liderança de autoria de 2000 a 2021 foi composta por homens até 2017, tendo um aumento de pesquisadoras publicando na área a partir de 2018. Observa-se a importância da manutenção e aporte de financiamentos e recursos para estudos sobre FP no país, objetivando a mensuração do impacto da doença. É necessário aumentar o número de pesquisadoras na ciência e nos estudos com mais ações de preservação de tartarugas marinhas e seu habitat natural, a fim de contribuir para o monitoramento da saúde de ecossistemas marinhos e habitats próximos da costa.
Palavras-chave: tartarugas marinhas, conservação, fibropapilomatose, cientometria, revisão da literatura.
Reviu Desain Struktur Bawah Bangunan Gedung: Studi Kasus Pengecekan Kekuatan Pondasi Tapak Sekolah Dasar Negeri (SDN) 12 Muntei, Mentawai
Authors: Fitria Winda , Misriani Merley , Syofyan Elvi Roza 
Published: February 2024

Muntei merupakan salah satu Desa di Kecamatan Siberut Selatan, Kabupaten Kepulauan Mentawai. Kepulauan Mentawai terletak di Provinsi Sumatera Barat dan berada di luar wilayah pulau Sumatera, termasuk dalam salah satu pulau terluar di Provinsi ini. Mentawai merupakan salah satu wilayah di Provinsi Sumatera Barat yang sering diguncang gempa. Sehingga penerapan standard bangunan tahan gempa menjadi faktor penting yang harus diperhatikan dalam upaya pengurangan resiko bencana di daerah ini, mengingat Provinsi Sumatera Barat termasuk salah satu daerah dengan resiko gempa yang tinggi. Penerapan standar bangunan tahan gempa seharusnya sudah dimulai semenjak proses perencanaan berlangsung, tidak hanya pada saat pelaksanaan konstruksi. Sebagai salah satu Provinsi terluar, Mentawai juga mengalami ketertinggalan dalam pembangunan infrastruktur, sehingga perlu dilakukan pembangunan berkelanjutan untuk membuat Mentawai keluar dari ketertinggalannya dibandingkan kota dan kabupaten lainnya di wilayah Sumatera Barat. SDN 12 Muntei merupakan salah satu bangunan publik yang berfungsi sebagai sekolah di Kepulauan Mentawai. Reviu desain pada pondasi tapak bangunan gedung sekolah SDN 12 Muntei ini bertujuan untuk memastikan kemampuan daya dukung dari pondasi. Data penelitian bersumber dari DED sebelum bangunan SDN 12 ini didirikan. Untuk mendapatkan nilai axial maksimal yang dipikul bangunan dilakukan permodelan dengan menggunakan aplikasi sap2000. Dari analisis data yang dilakukan, dapat disimpulkan bahwa pondasi yang ada pada DED tidak mampu memikul beban maksimal bangunan. Daya dukung izin pondasi tapak pada bangunan gedung SDN 12 Muntei ini adalah
sebesar 12.96 Ton, sementara beban maksimal yang bekerja pada bangunan adalah sebesar 34.57 Ton. Hasil analisis ini menunjukan bahwa penampang pondasi belum memenuhi syarat dan harus diperbaiki.
PENERAPAN METODE ANALYTIC HIERARCHY PROCESS (AHP) SEBAGAI SISTEM PENDUKUNG KEPUTUSAN DALAM PEMILIHAN SISWA BERPRESTASI DI SEKOLAH (Studi Kasus: Siswa Kelas VII dan Kelas VIII SMPN 2 Tongkuno)
Authors: Rezki Marni , Jufra  , Muhtar Norma , Somayasa Wayan , Alfian  , Adi Wibawa Gusti Ngurah 
Published: February 2024

Tujuan dari penelitian ini yaitu untuk mengetahui hasil pembobotan kriteria dan alternatif dalam pemilihan siswa berprestasi dengan menggunakan metode Analytic Hierarchy Process (AHP). Penelitian ini dilakukan dengan membuat matriks perbandingan berpasangan, menghitung nilai eigen dan vector eigen, menghitung bobot prioritas kriteria, sub kriteria dan alternatif menggunakan metode Analytic Hierarchi Process (AHP), menguji konsistensi indeks (CI) dan rasio konsistensi (CR). Hasil penelitian menunjukan bahwa pengaruh paling tinggi terhadap pemilihan siswa berprestasi adalah rata-rata raport dengan nilai bobot prioritas , selanjutnya adalah sikap dengan nilai bobot prioritas , kemudian absensi dengan nilai bobott prioritas dan yang terakhir adalah kegiatan ekstrakurikuler dengan niali bobot prioritas . Selanjutnya, untuk siswa berprestasi dari kelas VII adalah Alina Salsabila dengan nilai bobot dan untuk kelas VIII adalah Wisda Fadila dengan nilai bobot .
PENERAPAN METODE HUNGARIAN DALAM MENYELESAIKAN PENJADWALAN MATA KULIAH DI PROGRAM STUDI MATEMATIKA FMIPA UHO
Authors: Nirmala  , Arman  , Laome Lilis , Sani Asrul , Somayasa Wayan , Kabil Djafar Muhammad 
Published: February 2024

Penjadwalan mata kuliah merupakan kegiatan yang dilakukan untuk mengatur semua kegiatan perkuliahan oleh program studi perguruan tinggi. Tujuan dari penelitian ini adalah pembagian ruang kelas yang sesuai dengan jumlah peserta mata kuliah yang diprogramkan oleh mahasiswa. Masalah penjadwalan ini termasuk masalah penugasan. penjadwalan mata kuliah ini dapat diselesaikan dengan suatu metode yang disebut metode Hungarian. Penjadwalan mata kuliah ini dimodelkan menjadi model penugasan dengan memaksimumkan penggunaan ruang kelas.
Effectiveness of strontium/silver-based titanium surface coatings in improving antibacterial and osteogenic implant characteristics: a systematic review of in-vitro studies
Authors: Kheirmand-Parizi Marjan , Doll-Nikutta Katharina , Gaikwad Amit , Denis Hannah , Stiesch Meike 
Published: February 2024

Introduction: Due to the high incidence of implant failures, dual functionalization of titanium surfaces with antibacterial and osteogenic agents, like silver (Ag) and strontium (Sr), has gained significant attention in recent years. However, so far, the combined antibacterial and osteoinductive effectiveness of Ag/Sr-based titanium surface coatings has only been analyzed in individual studies.Methods: This systematic review aims to evaluate the existing scientific literature regarding the PICOS question “Does dual incorporation of strontium/silver enhances the osteogenic and anti-bacterial characteristics of Ti surfaces in vitro?”. As a result of a web-based search adhering to the PRISMA Guidelines using three electronic databases (PubMed, Scopus, and Web of Science) until March 31, 2023, a total of 69 publications were identified as potentially relevant and 17 of which were considered appropriate for inclusion into this review.Results and Discussion: In all included publications, the use of Sr/Ag combination showed enhanced osteogenic and antibacterial effects, either alone or in combination with other agents. Moreover, the combination of Sr and Ag shows potential to synergistically enhance these effects. Nevertheless, further studies need to validate these findings under clinically more relevant conditions and evaluate the mechanism of antimicrobial and osteogenic activity of Sr/Ag combination.
Efficient numerical simulations on the forest barrier for seismic wave attenuation: engineering safe constructions
Authors: Al-Shami Qahtan , Huang Jiankun , Amran Mugahed , Mugahed Saleh , Alluqmani Ayed Eid , Al-Haaj Mohammed , Gamil Yaser , Abdelgader Hakim S. 
Published: February 2024

This paper aims to elucidate the clear visibility of attenuating seismic waves (SWs) with forest trees as natural metamaterials known as forest metamaterials (FMs) arranged in a periodic pattern around the protected area. In analyzing the changeability of the FM models, five distinct cases of “metawall” configurations were considered. Numerical simulations were conducted to study the characteristics of bandgaps (BGs) and vibration modes for each model. The finite element method (FEM) was used to illustrate the generation of BGs in low frequency ranges. The commercial finite element code COMSOL Multiphysics 5.4a was adopted to carry out the numerical analysis, utilizing the sound cone method and the strain energy method. Wide BGs were generated for the Bragg scattering BGs and local resonance BGs owing to the gradual variations in tree height and the addition of a vertical load in the form of mass to simulate the tree foliage. The results were promising and confirmed the applicability of FEM based on the parametric design language ANSYS 17.2 software to apply the boundary conditions of the proposed models at frequencies below 100 Hz. The effects of the mechanical properties of the six layers of soil and the geometric parameters of FMs were studied intensively. Unit cell layouts and an engineered configuration for arranging FMs based on periodic theory to achieve significant results in controlling ground vibrations, which are valuable for protecting a large number of structures or an entire city, are recommended. Prior to construction, protecting a region and exerting control over FM characteristics are advantageous. The results exhibited the effect of the ‘trees’ upper portion (e.g., leaves, crown, and lateral bulky branches) and the gradual change in tree height on the width and position of BGs, which refers to the attenuation mechanism. Low frequency ranges of less than 100 Hz were particularly well suited for attenuating SWs with FMs. However, an engineering method for a safe city construction should be proposed on the basis of the arrangement of urban trees to allow for the shielding of SWs in specific frequency ranges.
Design of a multi-epitope vaccine against goatpox virus using an immunoinformatics approach
Authors: Long Qinqin , Wei Min , Wang Yuting , Pang Feng 
Published: February 2024

IntroductionGoatpox, a severe infectious disease caused by goatpox virus (GTPV), leads to enormous economic losses in the livestock industry. Traditional live attenuated vaccines cause serious side effects and exist a risk of dispersal. Therefore, it is urgent to develop efficient and safer vaccines to prevent and control of GTPV.MethodsIn the present study, we are aimed to design a multi-epitope subunit vaccine against GTPV using an immunoinformatics approach. Various immunodominant cytotoxic T lymphocytes (CTL) epitopes, helper T lymphocytes (HTL) epitopes, and B-cell epitopes from P32, L1R, and 095 proteins of GTPV were screened and liked by the AAY, GPGPG, and KK connectors, respectively. Furthermore, an adjuvant β-defensin was attached to the vaccine’s N-terminal using the EAAAK linker to enhance immunogenicity.ResultsThe constructed vaccine was soluble, non-allergenic and non-toxic and exhibited high levels of antigenicity and immunogenicity. The vaccine’s 3D structure was subsequently predicted, refined and validated, resulting in an optimized model with a Z-value of -3.4. Molecular docking results demonstrated that the vaccine had strong binding affinity with TLR2(-27.25 kcal/mol), TLR3(-39.84 kcal/mol), and TLR4(-59.42 kcal/mol). Molecular dynamics simulation results indicated that docked vaccine-TLR complexes were stable. Immune simulation analysis suggested that the vaccine can induce remarkable increase in antibody titers of IgG and IgM, higher levels of IFN-γ and IL-2.ConclusionThe designed GTPV multi-epitope vaccine is structurally stable and can induce robust humoral and cellular immune responses, which may be a promising vaccine candidate against GTPV.
Identification and characterization of a novel CASR mutation causing familial hypocalciuric hypercalcemia
Authors: Lin Chien-Ming , Ding Yi-Xuan , Huang Shih-Ming , Chen Ying-Chuan , Lee Hwei-Jen , Sung Chih-Chien , Lin Shih-Hua 
Published: February 2024

ContextAlthough a monoallelic mutation in the calcium-sensing receptor (CASR) gene causes familial hypocalciuric hypercalcemia (FHH), the functional characterization of the identified CASR mutation linked to the clinical response to calcimimetics therapy is still limited.ObjectiveA 45-year-old male presenting with moderate hypercalcemia, hypocalciuria, and inappropriately high parathyroid hormone (PTH) had a good response to cinacalcet (total serum calcium (Ca2+) from 12.5 to 10.1 mg/dl). We identified the genetic mutation and characterized the functional and pathophysiological mechanisms, and then linked the mutation to calcimimetics treatment in vitro.DesignSanger sequencing of the CASR, GNA11, and AP2S1 genes was performed in his family. The simulation model was used to predict the function of the identified mutant. In vitro studies, including immunoblotting, immunofluorescence, a cycloheximide chase study, Calbryte™ 520 Ca2+ detection, and half-maximal effective concentration (EC50), were examined.ResultsThis proband was found to carry a de novo heterozygous missense I554N in the cysteine-rich domain of CASR, which was pathogenic based on the different software prediction models and ACGME criteria. The simulation model showed that CASR I554N mutation decreased its binding energy with Ca2+. Human CASR I554N mutation attenuated the stability of CASR protein, reduced the expression of p-ERK 1/2, and blunted the intracellular Ca2+ response to gradient extracellular Ca2+ (eCa2+) concentration. The EC50 study also demonstrated the correctable effect of calcimimetics on the function of the CASR I554N mutation.ConclusionThis novel CASR I554N mutation causing FHH attenuates CASR stability, its binding affinity with Ca2+, and the response to eCa2+ corrected by therapeutic calcimimetics.
Analysis of white matter tract integrity using diffusion kurtosis imaging reveals the correlation of white matter microstructural abnormalities with cognitive impairment in type 2 diabetes mellitus
Authors: Gao Jie , Pan Peichun , Li Jing , Tang Min , Yan Xuejiao , Zhang Xin , Wang Man , Ai Kai , Lei Xiaoyan , Zhang Xiaoling , Zhang Dongsheng 
Published: February 2024

BackgroundThis study aimed to identify disruptions in white matter integrity in type 2 diabetes mellitus (T2DM) patients by utilizing the white matter tract integrity (WMTI) model, which describes compartment-specific diffusivities in the intra- and extra-axonal spaces, and to investigate the relationship between WMTI metrics and clinical and cognitive measurements.MethodsA total of 73 patients with T2DM and 57 healthy controls (HCs) matched for age, sex, and education level were enrolled and underwent diffusional kurtosis imaging and cognitive assessments. Tract-based spatial statistics (TBSS) and atlas-based region of interest (ROI) analysis were performed to compare group differences in diffusional metrics, including fractional anisotropy (FA), mean diffusivity (MD), axonal water fraction (AWF), intra-axonal diffusivity (Daxon), axial extra-axonal space diffusivity (De,//), and radial extra-axonal space diffusivity (De,⊥) in multiple white matter (WM) regions. Relationships between diffusional metrics and clinical and cognitive functions were characterized.ResultsIn the TBSS analysis, the T2DM group exhibited decreased FA and AWF and increased MD, De,∥, and De,⊥ in widespread WM regions in comparison with the HC group, which involved 56.28%, 32.07%, 73.77%, 50.47%, and 75.96% of the mean WM skeleton, respectively (P &lt; 0.05, TFCE-corrected). De,⊥ detected most of the WM changes, which were mainly located in the corpus callosum, internal capsule, external capsule, corona radiata, posterior thalamic radiations, sagittal stratum, cingulum (cingulate gyrus), fornix (stria terminalis), superior longitudinal fasciculus, and uniform fasciculus. Additionally, De,⊥ in the genu of the corpus callosum was significantly correlated with worse performance in TMT-A (β = 0.433, P &lt; 0.001) and a longer disease duration (β = 0.438, P &lt; 0.001).ConclusionsWMTI is more sensitive than diffusion tensor imaging in detecting T2DM-related WM microstructure abnormalities and can provide novel insights into the possible pathological changes underlying WM degeneration in T2DM. De,⊥ could be a potential imaging marker in monitoring disease progression in the brain and early intervention treatment for the cognitive impairment in T2DM.