bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lifetime Suicide Attempts in Otherwise Psychiatrically Healthy Individuals
Authors: Oquendo Maria A. , Wall Melanie , Wang Shuai , Olfson Mark , Blanco Carlos 
Published: February 2024

ImportanceNot all people who die by suicide have a psychiatric diagnosis; yet, little is known about the percentage and demographics of individuals with lifetime suicide attempts who are apparently psychiatrically healthy. If such suicide attempts are common, there are implications for suicide risk screening, research, policy, and nosology.ObjectiveTo estimate the percentage of people with lifetime suicide attempts whose first attempt occurred prior to onset of any psychiatric disorder.Design, Setting, and ParticipantsThis cross-sectional study used data from the US National Epidemiologic Study of Addictions and Related Conditions III (NESARC-III), a cross-sectional face-to-face survey conducted with a nationally representative sample of the US civilian noninstitutionalized population, and included persons with lifetime suicide attempts who were aged 20 to 65 years at survey administration (April 2012 to June 2013). Data from the NESARC, Wave 2 survey from August 2004 to September 2005 were used for replication. Analyses were performed from April to August 2023.ExposureLifetime suicide attempts.Main Outcomes and MeasuresThe main outcome was presence or absence of a psychiatric disorder before the first lifetime suicide attempt. Among persons with lifetime suicide attempts, the percentage and 95% CI of those whose first suicide attempt occurred before the onset of any apparent psychiatric disorders was calculated, weighted by NESARC sampling and nonresponse weights. Separate analyses were performed for males, females, and 3 age groups (20 to &amp;lt;35, 35-50, and &amp;gt;50 to 65 years).ResultsIn the total sample of 36 309 respondents, 1948 persons had lifetime suicide attempts; 66.8% (95% CI, 64.1%-69.4%) were female, and 6.2% (95% CI, 4.9%-7.4%) had no apparent lifetime psychiatric diagnoses when surveyed. In addition, 13.4% (95% CI, 11.6%-15.2%) made their first suicide attempt prior to psychiatric disorder onset. Thus, an estimated 19.6% of respondents first attempted suicide without an antecedent psychiatric disorder. No significant age or sex differences were detected in the percentage of those with lifetime suicide attempts absent psychiatric disorders, although females were more likely than males to attempt suicide in the year of psychiatric disorder onset (14.9% [95% CI, 12.5%-17.3%] vs 8.6% [95% CI, 6.0%-11.2%]; P &amp;lt; .001), and attempts were less frequent among those older than 50 to 65 years (3.9% [95% CI, 3.5%-4.4%] vs 6.1% [95% CI, 5.4%-6.8%] for 35-50 years and 6.2% [95% CI, 5.6%-6.9%] for 20 to &amp;lt;35 years; P &amp;lt; .001).Conclusions and RelevanceIn this study, an estimated 19.6% of individuals who attempted suicide did so despite not meeting criteria for an antecedent psychiatric disorder. This finding challenges clinical notions of who is at risk for suicidal behavior and raises questions about the safety of limiting suicide risk screening to psychiatric populations.
Total Neoadjuvant Therapy With PD-1 Blockade for High-Risk Proficient Mismatch Repair Rectal Cancer
Authors: Li Yingjie , Pan Chaohu , Gao Yuye , Zhang Li , Ji Dengbo , Cui Xiaoli , Zhang Xiaoyan , Cai Yong , Zhang Yangzi , Yao Yunfeng , Wang Lin , Leng Jiahua , Zhan Tiancheng , Wu Dongfang , Gao Zhibo , Sun Ying-Shi , Li Zhongwu , Luo Haitao , Wu Aiwen 
Published: February 2024

ImportanceTotal neoadjuvant therapy (TNT) is the standard treatment for locally advanced rectal cancer, especially for patients with high-risk factors. However, the efficacy of TNT combined with immunotherapy for patients with proficient mismatch repair (pMMR) rectal cancer is unknown.ObjectivesTo evaluate the safety and efficacy of TNT with induction chemoimmunotherapy followed by long-course chemoradiation in patients with high-risk, pMMR rectal cancer and to identify potential molecular biomarkers associated with treatment efficacy.Design, Setting, and ParticipantsThis cohort study was a single-arm phase 2 trial conducted at Gastrointestinal Cancer Center, Peking University Cancer Hospital &amp;amp; Institute, from June 2020 to October 2021. Biopsies and plasma were collected before treatment for whole-exome sequencing and cell-free DNA sequencing, respectively. Data were analyzed from May 2022 to September 2022.InterventionsParticipants received 3 cycles of induction oxaliplatin and capecitabine combined with camrelizumab and radiotherapy (50.6 Gy in 22 fractions) with concurrent capecitabine. Patients without disease progression received 2 cycles of consolidation oxaliplatin/capecitabine.Main Outcomes and MeasuresThe primary end point was pathologic complete response rate.ResultsOf 25 patients enrolled (19 men [76%]; 6 women [24%]; median [IQR] age, 58 [48-64] years), 22 patients (88%) completed the TNT schedule. The pathologic complete response rate was 33.3% (7/21). Twelve patients (48%) achieved clinical complete response, and 4 patients (16%) chose to watch and wait. R0 resection was achieved in 21 of 21 patients, and the major pathologic response rate was 38.1% (8/21). The most common adverse event was nausea (80%, 20/25); grade 3 toxic effects occurred in 9 of 25 patients (36%). Patients with tumor shrinkage of 50% or greater after induction oxaliplatin/capecitabine and camrelizumab or clinical complete response had higher percentages of LRP1B mutation. Mutation of LRP1B was associated with high tumor mutation burden and tumor neoantigen burden. Patients with high tumor mutation burden all benefited from therapy.Conclusions and RelevanceThis study found that TNT with induction chemoimmunotherapy followed by long-course chemoradiation was safe and effective for patients with high-risk rectal cancer with pMMR status. Longer follow-up and larger clinical studies are needed to validate this innovative regimen. There is also an urgent need to further validate the predictive value of LRP1B and discover other novel biomarkers with potential predictive value for rectal cancer.
Effects of differences in facility types on occurrence of COVID‐19 cases and response after testing positive in nursing homes for the elderly: Case study on Kyoto City
Authors: Suzuki Kenji 
Published: February 2024

AbstractThe outbreak of COVID‐19 became a major problem at various facilities, and aged‐care facilities were no exception. In the event of a person detected positive for the disease, outpatient facilities were suspended, but inpatient facilities could not be suspended, and it became necessary to deal with the residents and positive people. This study aimed to obtain knowledge that would lead to the prevention of the spread of COVID‐19. The effects of differences in facility types were first examined on the occurrence of COVID‐19 cases and then on the response after testing positive in nursing homes for the elderly.
Ball‐Milling Synthesis of Richly Oxygenated Graphene‐Like Nanoplatelets from used Lithium Ion Batteries and Its Application for High Performance Sodium Ion Battery Anode
Authors: Zhang Jiakui , Lei Yu , Zhou Lingyun , Chen Xianghong , Huang Shuhan , Liu Liang , Liu Huakun , Dou Shixue , Xu Jiantie 
Published: February 2024

AbstractThe exploration of waste graphite from used lithium ion batteries (LIBs) and its derivatives for versatile applications is an efficient route to promote the environmental and eco‐friendly recycling of used LIBs. Sodium ion batteries (SIBs) are alternative candidates to LIBs mainly due to similar electrochemical mechanism of SIBs to LIBs and rich natural resource of Na. Herein, a holey waste graphite (hGw) with well‐defined porous structure is produced by the annealing of lithiated waste graphite (Li/Gw) from used LIBs under a flow gas of H2O and subsequent lithium leaching in DI water. Benefiting from the holey structure of hGw, holey graphene nanoplatelets (hGnw) with ultrahigh‐level edge‐grafted oxygen groups (≈37.8 at%) are synthesized by mechanical balling of hGw. As anode for SIBs, the hGnw present outstanding sodium ion storage properties with high initial Coulombic efficiency of 82.4%, high reversible capacity (e.g., 416.1 mAh g−1 at 0.03 A g−1), excellent rate capability (e.g., 153.3 mAh g−1 at 2 A g−1), and long‐term cycling stability (e.g., 152.7 mAh g−1 after 400 cycles at 1.5 A g−1).
Peptide‐Based Supramolecular Therapeutics for Fighting Major Diseases
Authors: Wang Zhongyan , Luo Hongjing , Wang Heping , Xiao Meng , Jia Haixue , Ren Chunhua , Liu Jianfeng 
Published: February 2024

AbstractPeptide‐based supramolecular therapeutics (PST) refer to those theranostic nanomedicines based on peptide or peptide derivatives self‐assembly that are constructed in vitro or in vivo. Benefiting from the inherent advantages of peptides, such as good biocompatibility, high bioactivity, and flexible tunability, the reported PST have shown excellent application prospects in combating many major diseases including cancer, cardiovascular disease, infectious disease, autoimmune disease, metabolic disease, and so on. Through thoughtful design, the PST can be fabricated in various forms, including self‐assembled precursor molecules, functional nano‐assemblies, and macroscopic large‐scale hydrogels. The involved peptides in the PST can play different roles, such as serving drug carriers for effective delivery, acting as scaffold materials for cell culture, and functioning as bioactive sequences for treating diseases. In this review, a comprehensive overview of traditional strategies is provided to build PST and emphasize their therapeutic applications for fighting major diseases that pose a threat to human life and health. Moreover, the main challenges of PST in systems design, therapeutic application, and clinical translation are also briefly discussed. It is hoped that this review can arouse much more attention to be paid for PST and promote its practical application in the biomedical field.
Nanodiamond Implanted Zinc Metal Anode for Long‐Life Aqueous Zinc Ion Batteries
Authors: Wang Meiling , Zhang Jin , Wu Mengqi , Yang Di , Sun Peiyan , Sun Jie , Zhang Zeyu , Chen Xibang , Ba Junjie , Wang Yizhan , Qiu Jingyi , Wei Yingjin 
Published: February 2024

AbstractThe practical application of aqueous zinc ion batteries is greatly hindered by the severe dendrite growth and side reactions on the Zn metal anode. To address these challenges, nanodiamond (ND) particles are implanted on the Zn foil surface by a straightforward mechanical rolling process, which serves as heterogeneous seeds, enhancing the cycling stability of Zn metal anode. ND particles with carboxyl groups facilitate the even distribution of electric fields and Zn2+ ions in their vicinity, which promotes the homogeneous deposition of Zn. Moreover, the excellent corrosion resistance of ND particles alleviates the side reactions of the electrode, thus effectively protecting the Zn metal anode in aqueous electrolyte. Benefited from these advantages, the ND@Zn anode shows over 4100 h reversible cycles in symmetric cells, and 99.7% Coulombic efficiency in asymmetric cells. The ND@Zn||MnO2 full cell achieves a stable life of 1000 cycles with 87.0% capacity retention at 1 A g−1 current density. This cost‐effective fabrication process holds the potential for scalability, making it amenable to large‐scale production of zinc metal anodes.
Ordered Phase Distribution of Quasi‐2D Perovskites Controlled by a Supramolecular Approach Enables Efficient Blue Light‐Emitting Diodes
Authors: Yuan Shichen , Fang Tao , Han Boning , Shan Qingsong , Wei Changting , Zheng Xin , Li Xiansheng , Xu Bo , Zeng Haibo 
Published: February 2024

AbstractQuasi‐2D perovskites demonstrate exceptional luminescent properties, mainly attributed to heightened radiative recombination facilitated by the energy transfer process among spontaneous quantum‐well structures featuring varied n‐value distributions. However, the rapid crystallization process often induces uncontrolled variations in phase composition, characterized by distinct “n” values, leading to suboptimal energy transfer efficiency. In this study, an innovative supramolecular strategy utilizing cryptand is introduced as an additive to regulate the phase distribution within quasi‐2D perovskite films. Cryptand effectively inhibited the aggregation of PEA+ and the formation of unsaturated Pb‐X coordination compounds, thereby suppressing the generation of low‐“n” phases. This intervention resulted in a continuous series of ordered intermediate phases with higher “n” values. The graded electronic structure facilitated efficient energy transfer from low‐“n” to high‐“n” phases, promoting effective radiation recombination. As a result, the optimized PeLEDs emitting at 490 nm demonstrated a remarkable external quantum efficiency (EQE) enhancement to 10.16%, compared to the reference device with an EQE of 2.33%. The device also exhibited impressive spectral and operational stability. The findings establish a viable strategy for precise phase distribution regulation in quasi‐2D perovskites, offering great potential for high‐performance blue PeLEDs.
Patterned Chiral Perovskite Film for Self‐Driven Stokes Photodetectors
Authors: Wang Chao , Li Guoyi , Dai Zhipeng , Tian Wei , Li Liang 
Published: February 2024

AbstractPolarization detection plays an essential role in a wide range of fields, including target identification, 3D reconstruction, and robotic vision. Self‐driven on‐chip full‐Stokes photodetectors are urgently required to meet the trend of miniaturization and integration. Nevertheless, how to fulfill efficient circular and linear polarimetry simultaneously with sufficient recognition effectiveness in a compact device is a great challenge. Herein, a patterned chiral perovskite film is fabricated by imprinting strategy, and vertically‐structured self‐driven Stokes photodetector is demonstrated, which can recognize various polarization states at 0 V. Through patterned design of the chiral perovskite film by integrating circle and nanowire structure, flexible tuning of circular and linear polarization components within the detector is achieved, enabling the detector to strike a balance between circular and linear polarization detection ability when recognizing arbitrary polarization light. The maximum circular polarization sensitivity factor and linear polarization ratio can reach 0.125 and 1.5, respectively. By optimizing well‐defined patterned shape, the resultant detector can recognize polarized light with an average recognition error <7%. This work opens an avenue toward the fabrication of self‐driven filterless Stokes detectors based on patterned chiral perovskite film for accurate detection of arbitrary polarization states.
Fenton‐like Reaction Inspired “·OH Catalyzed” Osteogenic Process for the Treatment of Osteoporosis
Authors: Wang Jingcheng , Ye Jing , Yang Guoyu , Xie Jialiang , Miao Xinxin , Deng Jianjian , Wu Tianlong , Cheng Xigao , Wang Xiaolei 
Published: February 2024

AbstractInspired by the Fenton‐like reaction, this work combines copper peroxide (CP) nanoparticles with black phosphorus (BP) nanosheets to form a hydroxyl radical (·OH)‐centered “catalytic” osteogenic system. CP‐produced ·OH interacts with BP to rapidly produce a large amount of phosphate ions, thus accelerating self‐mineralization and promoting bone formation. In turn, BP not only exerts anti‐inflammatory effects, thereby providing a favorable microenvironment for bone formation, but also offsets the potential toxicity of CP induced by reactive oxygen species (ROS). Together with copper ions (Cu2+), phosphate ions are also released as a byproduct of this process, which can contribute to the comprehensive promotion of osteogenesis.
Cryo‐Electron Microscopy Reveals Na Infiltration into Separator Pore Free‐Volume as a Degradation Mechanism in Na Anode:Liquid Electrolyte Electrochemical Cells
Authors: Matthews Kevin C. , Rush Braxton , Gearba Raluca , Guo Xuelin , Yu Guihua , Warner Jamie H. 
Published: February 2024

AbstractBatteries utilizing a sodium (Na) metal anode with a liquid electrolyte are promising for affordable large‐scale energy storage. However, a deep understanding of the intrinsic degradation mechanisms is limited by challenges in accessing the buried interfaces. Here, cryogenic electron microscopy of intact electrode:separator:electrode stacks is performed and degradation and failure of symmetric Na||Na coin cells occurs through the infiltration of Na metal through the pores of the separator rather than by mechanical puncturing by dendrites is revealed. It is shown the interior structure of the cell (electrode:separator:electrode) must be preserved and deconstructing the cell into different layers for characterization results in artifacts. In intact cell stacks, minimal liquid is found between the electrodes and separator, leading to intimate electrode:separator interfaces. After electrochemical cycling, Na infiltrates into the pore free‐volume, growing through the separator to create electrical shorts and degradation. The Na infiltration occurs at interfacial regions devoid of solid‐electrolyte interphase (SEI), revealing SEI plays an important role in preventing Na from growing into the separator by being a physical barrier that the plated Na cannot penetrate. These results shed new light on the fundamental failure mechanisms in Na batteries and demonstrate the importance of preserving the cell structure and buried interfaces.
Self‐Powered Photodetector Based on Perovskite/Ge Heterojunction with High Responsivity
Authors: Wang Zeshu , Geng Xiangshun , Jin Jialun , Zhang Peigen , Zhang Li , Li Yuanyuan , Du Jingbo , He Yichu , Zhang Minshu , Peng Jiali , Qin Ken , Dun Guanhua , Wang Chunlin , Tian He , Xie Dan , Yang Yi , Ren Tian‐Ling 
Published: February 2024

AbstractSelf‐powered photodetectors (SPDs) are regarded as a new type of photodetectors without external energy sources, exhibiting great potential in the next generation of image sensing, biological detection, and robotics. Here, single crystal CH(NH2)2PbBr3 (FAPbBr3) perovskite with a low trap density of 1.64 × 109 cm−3 is directly integrated onto single crystal germanium (Ge). The band structure of the heterojunction belongs to type‐II alignment type, which is beneficial to the achievement of high responsivity. Therefore, the fabricated Au/FAPbBr3/Ge/Au detector exhibits a high responsivity of 0.33 A W−1, detectivity up to 3.83 × 1011 Jones and relatively fast decay time of 4.94 ms without external bias under 520 nm laser illumination. In addition, a prototype of an imaging system is set up utilizing the photodetector as a sensing pixel, from which the imaging function is verified. This work demonstrates a facile strategy for designing high‐performance SPDs.
3D‐Printed Lipid Mesophases for the Treatment of Chronic Liver Disease
Authors: Carone Marianna , Gazzi Rafaela , Eugster Remo , Gelli Rita , Manten Niklaas , Ganguin Aymar A. , Valerio Silvia Di , Yadav Garima , Castaldo Pasqualina , Mezzenga Raffaele , Luciani Paola , Aleandri Simone 
Published: February 2024

AbstractAlthough lipid‐based formulations are an attractive approach for enhancing the oral bioavailability of lipophilic drugs, their addition into solid oral dosage forms has been proven challenging due to their high viscosity and heat sensitivity. Therefore, unlike the traditional tableting process, this study employed semi‐solid extrusion 3D‐printing to produce–at room temperature–gastro‐resistant printlets containing a high percentage of bioactive lipids for the effective delivery of lipophilic drugs through self‐emulsification. The bio‐compatible lipidic mesophase ink, owing to a tunable 3D nanostructure, is employed as a starting material to produce printlets via additive manufacturing. An active lipid mixture – with antifibrotic properties – is blended with the antioxidant vitamin E and water, and the ink printability is optimized by carefully tailoring its composition, and thus its phase identity. The obtained printlets disintegrated upon contact with intestinal fluids forming colloidal structures that enhanced the solubility of a poorly water‐soluble drug. The printlets exhibited antifibrotic activity on human hepatic stellate cells, LX‐2, suggesting that the generated self‐emulsified colloidal structures made both the fibrosis‐resolving bioactive excipients and the drug promptly available, enhancing their cell uptake and, in turn, their therapeutic activity.
Considerations for the Design and Rapid Manufacturing of Pop‐Up MEMS Devices
Authors: Ramirez Serrano Francisco , Steinhardt Emma , Wood Robert J. 
Published: February 2024

AbstractThe rising number of devices created using pop‐up microelectromechanical systems (MEMS) and related folding‐based assembly techniques highlights the need for robust design and manufacturing workflows to support the wide range of device variations. To push the bounds of miniaturization, design for manufacturing is key in dealing with fabrication challenges. Iterative building of intermediate device prototypes is a promising way to explore an often very large design space and can highlight mechanical limitations that may not be obvious to the designer. Manufacturing of pop‐up MEMS devices is, however, typically a lengthy process with lamination taking a significant percentage of the build time, compared to layer machining and component assembly. To expedite the design process, researchers often prototype multiple iterations at larger scales prior to committing to at‐scale designs. In this study, an at‐scale rapid prototyping workflow for pop‐up MEMS devices is introduced. This study also includes flexure design considerations for castellated hinges, to approach the behavior of an ideal pin joint. The new proposed workflow uses more accessible lower‐cost equipment and materials and reduces lamination time by over 95% (10 min lamination vs a 3.5 h lamination) compared to the previous heated press process, which is validated through a series of prototypes.
Heterostructure of Reduced Titanium Dioxide Nanorods and Small Molecules Leads to Photo‐Induced Negative Differential Resistance Behaviors
Authors: Lee Gyeongho , Han Youngmin , Lee Ho kyung , Yoo Hocheon , Kim Yeong Jae 
Published: February 2024

AbstractNegative differential resistance (NDR) is of considerable interest due to the uncommon characteristic of having a region where the current decreases as the applied voltage bias increases. However, it is difficult to reproduce NDR devices and evaluate their reliability and stability because of the unstable NDR behaviors. In this paper, a highly stable photo‐induced hybrid photonic (HP)‐NDR device is presented for practical applications, which has heterostructure between TiO2‐x nanorods formed by oblique angle deposition and dinaphtho[2,3‐b:2′,3′‐f]‐thieno[3,2‐b]thiophene. The mechanism of NDR behaviors is investigated through morphological analysis, energy band structure, and electrical characteristics. In addition, diverse bias stress and endurance measurements are performed to demonstrate the reliability of the HP‐NDR device. As a result, the NDR behavior lasts up to 1,000 s in each bias stress and 38,850 cycles in the repeated current–voltage (I–V) characteristics Thus, the study has successfully achieved robust HP‐NDR devices with potential for practical applications.