bluuebunny/crossref_metadata_2025_split huggingface dataset:
Carcinoembryogenic antigen and lysosomal enzymes in gastric juice as an aid in the diagnosis of gastric cancer
Authors: Graffner H. , Hultberg B. 
Published: February 2007

AbstractMalignant transformation in cells is accompanied by enzymatic changes that may be useful markers of malignancy. Studies of oncofetal antigens in gastric juice show an increased concentration in patients with gastric carcinoma. The object of the present study was to test if the concentration of lysosomal enzymes and carcinombryonic antigen (CEA) were altered in patients with gastric carcinoma compared to patients earlier operated with gastric resection—a supposedly premalignant condition. The results show that no differences could be found in CEA and β‐hexosaminidase levels between the patients with gastric carcinoma and those with gastric resection. However, lysozyme content was significantly higher in gastric carcinoma and might prove useful for screening of patients after gastric resection. Both CEA, β‐hexosaminidase, and lysozyme levels were significantly higher in patients with gastric carcinoma than in a control population, and can therefore have a role in screening of asymptomatic patients.
Hodgkin disease clinical stages I, II, and III (A, B): Results of radiotherapy with or without chemotherapy
Authors: Patricio M. Brites , Ricardo J. A. , Vilhena M. , Branco F. , de Ponte M. A. , Cabral R. , Neves M. , de Sousa J. V. 
Published: February 2007

AbstractBetween 1961 and 1976, 387 patients with Hodgkin disease were examined, evaluated, and treated at the Instituto Portugues de Oncologia de Francisco Gentil. After reviewing histological and clinical staging presentation, the authors retrospectively analyzed the results obtained with 303 patients classified in clinical stages I, II, and III (A, B) who were treated with or without chemotherapy in two time periods (before and after 1970) according to individual therapeutic modalities. The improvement of the 5‐year survival rates in the last period was associated with the introduction of extended‐field irradiation and multidrug chemotherapy (MOPP). However, the incidence of serious complications was higher in the group of patients subjected to combined field irradiation and MOPP. The authors suggest a stricter protocol based on the current recommendations for the treatment of Hodgkin disease in order to achieve better results with minimum possible hazards.
The contribution of the physical sciences to the development of radiation therapy
Authors: Hall Eric J. 
Published: February 2007

AbstractRadiation therapy is used in the treatment of about half of all cancer patients in the United States. The development of this specialty has been intimately involved with major advances in the physical sciences, from the discovery of x‐rays by Roentgen and radium by the Curies, to the technological breakthroughs of World War II that led to the 60cobalt teletherapy unit and the modern linear accelerator‐the principal treatment machines in use today. These historical events are described and the principal characters introduced.
Streptozotocin prevents development of nitrosamine‐induced pancreatic cancer in the syrian hamster
Authors: Bell Richard H. , Strayer David S. 
Published: February 2007

AbstractAdministration of the nitrosamine carcinogen N‐nitroso‐bis (2‐oxopropy 1) amine (BOP) by subcutaneous injection (5 mg/kg/week) led to the development of invasive pancreatic ductular adenocarcinoma in 100% of normal Syrian hamsters by 24 weeks. Pretreatment of a second group of hamsters with the beta‐cell toxin streptozotocin in a diabetogenic dose (50 mg/kg i.p × 3) completely prevented the development of pancreatic cancer when BOP was subsequently administered. The mechanism of blockade by streptozotocin is unknown. This study suggests the potential importance of the endocrine pancreas in exocrine pancreatic carcinogenesis.
Coexisting carcinoid tumor and Crohn's disease
Authors: van Landingham Samuel B. , Kluppel Shannon , Symmonds Richard , Snyder Samuel K. 
Published: February 2007

AbstractSeveral malignancies have been described occurring simultaneously with regional enteritis. Only four examples of coexistent carcinoid and Crohn's disease have been described worldwide. In this report, two new cases of simultaneous Crohn's disease and carcinoid tumor, diagnosed and treated within a single month, are presented. In one instance, a segment of terminal ileum contained regional enteritis, carcinoid tumor, and a small focus of adenocarcinoma.
Primary retroperitoneal soft‐tissue sarcomas
Authors: Adam Yehuda G. , Oland Jan , Halevy Ariel , Reif Renate 
Published: February 2007

AbstractOf the 98 soft‐tissue sarcomas treated between 1973–1978, 12 were retroperitoneal in origin. Fifty percent underwent one to three previous surgical procedures. All patients were operated on. In 75% (nine out of 12), the tumor was completely resected. The operative mortality for total tumor excision was 11%. There were five liposarcomas, three leiomyosarcomas, two neurofibrosarcomas, and one synovial sarcoma and one unclassified sarcoma. Six of the 12 patients survived five years and three (25%) were alive without evidence of disease at 5 years. Three of the completely resected group received no further treatment; 2/3 survived 5 years; three had postoperative chemotherapy; 3/3 survived; and three others had radiation and chemotherapy subsequent to surgery; all three have died. The two most important prognostic factors were tumor grade and surgical excision. Only one patient with high grade tumor survived. Total surgical excision of the tumor offers the only hope for cure. Aggressive surgery in treating retroperitoneal soft part sarcomas is strongly recommended.
Electrocautery: Effects on steroid receptors in human breast cancer
Authors: Bloom Norman D. , Johnson Frank , Pertshuck Lewis , Fishman Jerry 
Published: February 2007

AbstractThe determination of steroid receptors in human breast cancers has assumed increasing importance over the past several decades. Improper handling of the specimens could affect results obtained. This study details the effects excessive levels of heat that occur with the use of electrocautery can have on steroid receptor quantities and localization. Twelve resected primary and metastatic human breast cancers were analyzed for cytoplasmic and nuclear receptors by biochemical analysis. In addition, steroid binding was determined by direct fluorescent histochemical techniques. To a portion of each resected specimen a Boviec was applied to simulate electrocautery resection. Analysis of the different portions of the same tumor revealed that there was a decrease in measurable cytoplasmic receptor in all cauterized specimens and a concomitant increase in the nuclear receptor. A similar shift in steroid binding was noted in all the specimens analyzed by fluorescent histochemical techniques. The results of this study show that the application of excessive heat to human breast cancers will lead to false negative biochemical steroid receptor determination by shifting the receptors intranuclear.
Steroid hormone receptors in breast tumours presenting during pregnancy or lactation
Authors: Holdaway I. M. , Mason B. H. , Kay R. C. 
Published: February 2007

AbstractCytosol oestrogen receptor (ER) and progesterone receptor (PR) levels were measured in tumours from three patients with breast cancer during pregnancy and from three patients developing breast cancer while lactating. All lactating patients were ER‐positive and two were PR‐positive, whereas pregnant patients were uniformly ER‐negative and PR‐negative. Pregnant patients had a significantly shorter disease‐free survival compared with matched nonpregnant women with breast cancer. Of five patients developing metastatic disease, one from the lactating group had a complete remission with chemotherapy and one had static disease with endocrine treatment, whereas all others had progressive disease despite a variety of treatments. Although numbers are too small to permit generalisation, these provisional data suggest that patients presenting with breast cancer during pregnancy may have mainly receptor‐negative tumours, a short disease‐free interval, and may be relatively resistant to treatment of metastatic disease. By comparison, patients with breast tumours during lactation have receptor‐positive disease and metastases may respond to systemic therapy.
Squamous carcinoma of the thymus
Authors: Chen Karl T. K. 
Published: February 2007

AbstractA rare case of squamous carcinoma of the thymus is described and the literature is reviewed. This type of thymic carcinoma is surgically curable even in the presence of local invasion. It also appears radiosensitive with apparent cure by radiotherapy alone observed. Its prognosis is better than squamous carcinoma of the lung with mediastinal involvement, and lymphoepithelioma‐like thymic carcinoma.
Survival following orchiectomy for stage D adenocarcinoma of the prostate
Authors: Forrest John B. , Howards Stuart S. 
Published: February 2007

AbstractThe survival of nonprivate and private patients following orchiectomy for stage D adenocarcinoma of the prostate was studied. While the private patients enjoyed a longer survival, their improved survival was found to be a function of an earlier presentation. Examination of the survival statistics with linear regression analysis suggested that survival following orchiectomy is a function of the age at the time of orchiectomy.
Mesenchymoma of the retrorectal space: A case report and review of literature
Authors: Schittek Anton , Clausen Kathryn P. , Minton John P. 
Published: February 2007

AbstractAlthough sarcoma occurring in the true retroperitoneum is not uncommon, sarcoma in the retrorectal space is unique. We report a patient with a malignant mesenchymoma, a rare soft tissue tumor, in the retrorectal space. Complete resection was accomplished through a combined Kraske's posterior and midline anterior approach. The rectum had not been invaded by the mass. Survival of patients with malignant mesenchymoma does not exceed 50% in most reports, and the role of adjuvant chemotherapy or radiation has yet to be defined. Its attendant morbidity must be weighed against an uncertain prognosis.
Ischemic necrosis of proximal gastric remnant following subtotal gastrectomy with splenectomy
Authors: Isabella V. , Marotta E. , Bianchi F. 
Published: February 2007

AbstractIschemic necrosis of the gastric remnant is a rare and serious complication of high subtotal gastrectomy, rarely of the distal resection of the stomach. The authors report one case after subtotal gastrectomy with splenectomy, review the literature about this subject, and suggest that in all procedures the surgeon must take full account of the variability of gastric blood flow. Conservative therapy of this complication with total parenteral nutrition is proposed.
Multilocular cystic renal adenocarcinoma: A case report and review of the literature
Authors: Takeuchi T. , Tanaka T. , Tokuyama H. , Kuriyama M. , Nishiura T. 
Published: February 2007

AbstractA case of multilocular cystic renal adenocarcinoma is presented. Although the multilocular renal cyst is an uncommon lesion, nine cases of these lesions associated with adenocarcinoma have been reported in the English literature so far. The related reports are reviewed in addition to three cases in the Japanese literature.
Bile duct tumours: Prolonged survival by radiological management of T‐tubes
Authors: Gordon Roy L. , Bloom Ronald A. , Engelberg M. , Weshler Z. 
Published: February 2007

AbstractCarcinoma of the common bile duct is generally a slow‐growing tumour which causes death by hepatic failure and ascending cholangitis secondary to obstruction. Internal drainage by surgical placement of a T‐tube bypassing the tumour is widely employed, but survival times are generally short, averaging 9.9 months. The interventional radiologist can offer considerable prolongation of life with reduced hospitalization by means of percutaneous tube cleaning and catheter replacement. A case is presented where survival has been prolonged to 37 months by routine radiological catheter care.
Successful immunotherapy in a murine metastasizing fibrosarcoma model
Authors: Cortes Ruben , Correa Luis A. , Behbehani Abdulla I. , Sonis Stephen T. , Wilson Richard E. 
Published: February 2007

AbstractAntigenic differences were demonstrated between the primary murine fibrosarcoma and its metastases. Immunization with irradiated primary tumor cells (TC) protected C57B1/6J mice against subsequent challenge with those cells, but not against challenge with cells from pulmonary metastases (PMC). Mice immunized with irradiated PMC were protected from challenge with those cells, but not against challenge with TC. Mice with fibrosarcomas produced by the injection of 5 × 103 cells from the primary tumor were treated by resection of the tumor‐bearing limb (Amp), Amp plus cylcophosphamide (Amp+Cy), Amp plus primary TC (Amp+TC), Amp plus primary TC and from its metastatic variant (Amp + TC + PMC), and with combinations of the last two groups with Cy. Although Amp+Cy improved survival, no animal lived 100 days and metastases increased as compared to controls. Immunotherapy significantly improved survival and decreased pulmonary metastases. Antigen combinations from primary and metastatic tumors resulted in significantly better survival than did a single preparation only from TC. Chemotherapy did not enhance the results obtained with immunotherapy and surgery. Immunity conferred in long‐term survivors was permanent.
Plasma histaminase activity in carcinoma of the cervix—Its clinical significance
Authors: Birdi Ashwi , Gupta Saroj , Gambhir S. S. 
Published: February 2007

AbstractPlasma histaminase activity has been estimated in 79 patients with squamous cell carcinoma of the cervix. The mean plasma histaminase value is significantly higher in patients than in controls (P < 0.001). The plasma histaminase activity falls significantly following radiotherapy (P < 0.001). Pretreatment plasma histaminase values do not show any correlation with clinical stages and the posttreatment values decline significantly but remain higher in clinical stages III and IV than in stages I and II. The increased plasma histaminase activity also reflects the degree of differentiation within the tumor. Further it is noted that the plasma histaminase value is inversely proportional to the radiation response. It is suggested that estimation of plasma histaminase activity can serve as an important marker in assessing the treatment response and monitoring the course of treatment.
Disseminated Kaposi's sarcoma in a patient with acquired ichthyosis
Authors: Bechtel Mark A. , Callen Jeffrey P. 
Published: February 2007

AbstractAn elderly black male with Kaposi's sarcoma of the skin and lymph nodes is presented. The patient developed several violaceous papules involving the nose, which suggested a diagnosis of sarcoidosis clinically but proved to be Kaposi's sarcoma on biopsy. His clinical course was complicated by the development of acquired ichthyosis. The prognosis and treatment of generalized Kaposi's sarcoma is discussed.
The effect of malignant epithelial tumors, surgical therapy, and bacterial sepsis upon various parameters of interferon system
Authors: Ikossi‐O'connor M. C. , Chadha Kailash C. 
Published: February 2007

AbstractThe influence of tumor load, surgical trauma, and bacterial sepsis upon the ability of patient's peripheral leukocytes to produce interferon‐α (IFN‐α), the detectable serum IFN levels and circulating serum IFN inactivators were studied. Peripheral blood leukocytes of patients with solid tumors had significantly reduced ability to produce IFN‐α. Complete resectional surgery resulted in restoration of their ability to produce normal IFN‐α levels. Circulating IFN levels were detectable in 70% of patients with localized disease while only in 20% of patients with metastatic disease. Interferon‐α activators were detected in 45% of all patients. Both circulating interferon and IFN‐α inactivators became undetectable upon tumor resection. Surgical trauma is accompanied by a transient but definite decrease in IFN‐α production capability. Bacterial sepsis during postoperative days, in patients who successfully recovered, was definitely accompanied by increase in IFN‐α production capability. Our findings suggest that advanced malignant epithelial tumors have an adverse effect upon the patient's ability to produce interferon and are often accompanied by the presence of circulating serum interferon inactivators. These effects can be reversed by surgical resection of the malignant neoplasm.
Improved tissue perfusion during pressure‐regulated hyperthermic regional isolated perfusion in dogs
Authors: Fontijne W. P. J. , De Vries J. , Mook P. H. , Elstrodt J. M. , Oosterhuis J. W. , Koops H. Schraffordt , Oldhoff J. , Wildevuur C. R. H. 
Published: February 2007

AbstractTo achieve adequate tissue perfusion during regional isolated perfusion, hind limbs of dogs were perfused for 60 min, regulating the extracorporeal circuit on pressure. The dogs were divided into three groups. In groups I and II perfusions were performed at a delta pressure (systemic mean arterial pressure minus hind limb mean arterial pressure) of respectively 50 and 15 mm Hg; in group III delta pressure was also 15 mm Hg but the cytostatic drug Melphalan was added. Tissue perfusion was determined by means of a multiwire polarographic oxygen electrode. Adequate tissue perfusion was obtained only at subnormal perfusion pressures (groups II and III), although in all groups perfusion flow was higher than preoperative flow. At low perfusion pressures (group I), tissue perfusion was severely impaired. In all groups leakage remained less than 10%. During regional isolated perfusion the extracorporeal circuit must be regulated at a delta pressure of 15 mm Hg to achieve adequate tissue perfusion.
A trial of adjuvant combination chemoimmunotherapy for stage III carcinoma of stomach
Authors: Akiyoshi Tsuyoshi , Kawaguchi Michihiro , Arinaga Shinya , Miyazaki Soichiro , Koba Fumio , Wada Tetsuya , Tsuji Hideo 
Published: February 2007

AbstractA chemoimmunotherapy program designed on the basis of experimental results was administered to 27 patients with stage III carcinoma of stomach following curative resection. The treatment regimen consisted of active immunotherapy with Vibrio cholerae neuraminidase (VCN)‐treated autologous tumor cells admixed with bacillus Calmette‐Guérin (BCG) and chemotherapy with drugs such as cyclophosphamide (CY), mitomycin C (MMC), and 5‐fluorouracil (FU) which proved to enhance the immune response when administered at optimal dose and timing. Then, it was followed by long‐term administration of tegafur (FT) and immunomodulators. This treatment significantly improved survival when compared to that of 41 historical control patients treated with surgery alone (P < 0.001). As compared to 31 control patients concurrently treated with a bolus dose of MMC followed by long‐term FT and immunomodulators, survival had a tendency, but not significantly, to be improved in patients treated with this therapy (P < 0.1). However, the survival rate at 4.5 years was significantly higher than that of control patients (P < 0.01). These results appeared to show that this type of adjuvant combination chemoimmunotherapy may be of benefit for this group of patients with gastric carcinoma.
Failure of subcutaneous mastectomy to prevent the development of breast cancer
Authors: Goodnight James E. , Quagliana Joseph M. , Morton Donald L. 
Published: February 2007

AbstractThree patients treated with bilateral subcutaneous mastectomies and implants for fibrocystic disease or carcinoma in situ subsequently developed invasive breast carcinoma. These cases emphasize that subcutaneous mastectomy does not prevent the development of breast cancer. If the circumstances in an individual patient justify prophylactic mastectomy, then the appropriate procedure would seem to be total mastectomy, which would accomplish thorough removal of all breast tissue, the subareolar region, and the nipple. Subcutaneous mastectomy for the patient who is likely to harbor occult invasive disease seems particularly inappropriate. As a means to reduce the risk of breast cancer, the procedure is unproved and must be considered an experimental therapeutic approach.
Gastric cancer in young patients
Authors: Ikossi‐O'connor M. G. , Douglass H. O. 
Published: February 2007

AbstractA retrospective review of the Roswell Park Memorial Institute experience and literature review of gastric carcinoma in young adults reveals that long‐term survival is rarely achieved. The primary correctable cause of failure is a very long delay in diagnosis, a result of both reluctance to initiate diagnostic studies and inaccuracy of routine upper gastrointestinal series. A high index of suspicion and liberal utilization of gastroscopy and gastric cytology combined with an aggressive surgical approach to gastric pathology would probably lead to improved survival for the young gastric carcinoma patients.
Local control in advanced head and neck cancer by combined modalities of treatment
Authors: Jose Baby , Desmukh Yusuf , Sharma Subhash C. 
Published: February 2007

AbstractFrom July 1979 to January 1983, 20 patients with locally advanced head and neck cancer were treated with a combination of chemotherapy and irradiation with or without surgery. A majority of the patients were in the age range of 45 to 54 years. Eighty‐five percent of the patients were male. Seventy‐five percent of the patients had oral cavity lesions, the tongue being the most common site. Eighty percent of the patients had T4 lesion and 35% had N3 disease in the neck. A majority of the patients had combination chemotherapy, including bleomycin, methotrexate, and cis‐platinum (BMP). All patients received irradiation with megavoltage equipment and 55% of patients received a dose of 5,000 to 6,000 rads in 5–6 weeks time. The tumor was converted to be resectable in ten patients. Nine patients (45%) had the neck and primary tumor completely controlled, while six patients (30%) had partial control. Six of the ten patients who had resection had the tumor controlled at the primary site and neck. The median duration of follow‐up is 12 months (range, 4–32 months). The median survival of the whole group of patients is 12.5 months. A brief review of the current literature is also done in this paper.
Arterial thromboembolic complications of peritoneovenous shunting for malignant ascites
Authors: Paschold E. H. , Jackson Don V. , Albertson D. A. , Woodruff R. D. 
Published: February 2007

AbstractPeritoneovenous shunting for the treatment of malignant ascites has become increasingly popular. This technique can be complicated by tumor embolization, congestive heart failure, and disseminated intravascular coagulation. Arterial thromboembolism has been encountered in two patients following LeVeen shunt insertion. Recurrent bilateral femoral artery thromboemboli and a cerebrovascular accident occurred in one patient and cerebrovascular thromboembolism developed in a second patient. Major arterial embolization is potentially a serious, although infrequent, complication of peritoneovenous shunting in patients who have malignant ascites.