bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Electronic Health Record–Integrated Application for Standardizing Care and Monitoring Patients With Autosomal Dominant Polycystic Kidney Disease Enrolled in a Tolvaptan Clinic: Design and Implementation Study
Authors: Chedid Maroun , Chebib Fouad T , Dahlen Erin , Mueller Theodore , Schnell Theresa , Gay Melissa , Hommos Musab , Swaminathan Sundararaman , Garg Arvind , Mao Michael , Amberg Brigid , Balderes Kirk , Johnson Karen F , Bishop Alyssa , Vaughn Jackqueline Kay , Hogan Marie , Torres Vicente , Chaudhry Rajeev , Zoghby Ziad 
Published: March 2024

Abstract

Background
Tolvaptan is the only US Food and Drug Administration–approved drug to slow the progression of autosomal dominant polycystic kidney disease (ADPKD), but it requires strict clinical monitoring due to potential serious adverse events.

Objective
We aimed to share our experience in developing and implementing an electronic health record (EHR)–based application to monitor patients with ADPKD who were initiated on tolvaptan.

Methods
The application was developed in collaboration with clinical informatics professionals based on our clinical protocol with frequent laboratory test monitoring to detect early drug-related toxicity. The application streamlined the clinical workflow and enabled our nursing team to take appropriate actions in real time to prevent drug-related serious adverse events. We retrospectively analyzed the characteristics of the enrolled patients.

Results
As of September 2022, a total of 214 patients were enrolled in the tolvaptan program across all Mayo Clinic sites. Of these, 126 were enrolled in the Tolvaptan Monitoring Registry application and 88 in the Past Tolvaptan Patients application. The mean age at enrollment was 43.1 (SD 9.9) years. A total of 20 (9.3%) patients developed liver toxicity, but only 5 (2.3%) had to discontinue the drug. The 2 EHR-based applications allowed consolidation of all necessary patient information and real-time data management at the individual or population level. This approach facilitated efficient staff workflow, monitoring of drug-related adverse events, and timely prescription renewal.

Conclusions
Our study highlights the feasibility of integrating digital applications into the EHR workflow to facilitate efficient and safe care delivery for patients enrolled in a tolvaptan program. This workflow needs further validation but could be extended to other health care systems managing chronic diseases requiring drug monitoring.
The Growth Response of Rendeu (<i>Staurogyne elongata</i> (Neese) Kuntze) to Shoot Pruning and Its Propagation by Shoot Cutting
Authors: Lailaty Intani Quarta , Astutik Sri , Surya Muhammad Imam 
Published: March 2024

Rendeu (Staurogyne elongata (Neese) Kuntze) is a native Indonesian plant used as food and traditional medicine in the daily life of the people residing around Gunung Halimun-Salak National Park. Due to the potential source of herbal-based medicines and traditional food in the long-run purposes, the proper method of its propagation is required, so that Rendeu can be conserved and utilised sustainably. This study employed two research designs. First, a completely randomized design with pruning and IAA (indole-3 acetic acid) treatment was used for seedling growths. Second, plant propagation applied a factorial randomized block design: planting media types and plant growth regulator (PGR) (rootone F) treatment. Observation included the number of buds, number of leaves, number of flowers, plant biomass, root length, and relative chlorophyll content using the SPAD tool. The data were analysed using ANOVA (SPSS ver. 17.0), followed by Pearson correlation analysis. The results showed that applying IAA and leaf pruning could increase the number of buds, the number of leaves and the fresh weight of S. elongata plants compared to the control plant. The addition of rootone increased the growth of Rendeu shoot cuttings, shown in all growth parameters and chlorophyll content. Humus was the best media for Rendeu’s growth among all planting medium. Planting media affected the increase in the number of leaves and the number of buds of S. elongata significantly. The interaction of planting media and PGR somewhat influenced root length and total leaf chlorophyll. The growth and production of S. elongata increased with the time of planting.
Nannoplankton Biostratigraphy from Banggai-Sula Basin, Central Sulawesi
Authors: Nurhidayah Efrilia Mahdilah , Akmaluddin Akmaluddin , Barianto Didit Hadi , Husein Salahuddin , Saripudin Asep 
Published: March 2024

The nannoplankton research was conducted in the MH-2 well, Banggai-Sula Basin, Central Sulawesi. Thirty-four ditch-cutting samples were utilized to observe the Minahaki, Kintom, and Biak Formations. Age determination was carried out using biostratigraphy method and standard procedure for first and last occurrence of nannoplankton biodatum and had an absolute age, widely known as a zone indicator. This study aims to determine the age and nannoplankton biozonation of each geological formation in Banggai-Sula Basin. Based on the biostratigraphic analysis, 39 species from 14 genera with abundance frequencies ranging from rare to abundant were found in the MH-2 well. In this study, new results of the age of Banggai-Sula Basin areMiddle Miocene – Early Middle Pliocene (13,706 – 3,727 Ma), and can identify into six calcareous nannoplankton zones that are more detailed than previous researchers, Discoaster signus zone (NN5), Discoaster exilis zone (NN6-NN7), Discoaster berggrenii zone (NN11), Ceratolithus acustus zone (NN12), Helicosphaera sellii zone (NN13-NN15), and the Discoaster tamalis zone (NN16). Biostratigraphic data also shows new information for the first time, the absence of three zones from zone NN8 to zone NN10. This result indicates an unconformity in the Late Miocene age (10.606–8.20 Ma).
Lead (Pb)-Resistant Bacteria Improve <i>Brassica chinensis</i> Biomass and Reduce Pb Concentration in Pb-Contaminated Soil
Authors: Pertiwi Beauty Laras Setia , Ustiatik Reni , Nuraini Yulia 
Published: March 2024

Applications of inorganic fertilisers and pesticides frequently increase lead (Pb) content in the soil and food crops. This study aims to isolate Pb-resistant bacteria and test the isolated bacteria in reducing Pb concentration and increasing biomass production of Brassica chinensis on Pb-contaminated soil. Soil and plant samples were collected from agricultural land in Batu City, East Java, Indonesia. The isolated bacteria were tested for Pb resistance and then characterised according to 16S rRNA Sequence. A pot trial with a completely randomised block design consisting of 9 treatments and 3 replications was set to determine the effect of Pb-resistant bacteria inoculation on Pb residue, plant growth, and soil nutrients. The result showed that the isolated Pb-resistant bacteria were Bacillus wiedmannii and Bacillus altitudinis. The bacteria were resistant to Pb up to 10,000 mg/L PbNO3. Inoculation of the bacteria increased B. chinensis growth and biomass production, namely increasing the number of leaves (12%) and dry weight (35%). Also, the bacteria reduced Pb residue in the soil by up to 88%. Moreover, soil essential nutrients such as total nitrogen, available phosphorus, and exchangeable potassium increased (12%, 73%, and 200%, respectively) after the application of Pb-resistant bacteria. The bacteria have the potential for bioremediation of Pb-contaminated soils on a large scale due to the bacteria prevent Pb uptake by food crops such as B. chinensis by reducing Pb content in the soil, which is good for food safety and environmental sustainability.
Economic Valuation of Tourist Attractions with Travel Cost Approach
Authors: Susilowati Indah , Musliha Cici , Al-Hafidz Zulfikar , Prabowo Sigit , Sari Dwi Putri Wulan , Ardana Raditya 
Published: March 2024

Umbul Sidomukti is an excellent tourist area with several tourist objects. Umbul Sidomukti tourism was designated as a tourist attraction because the area has a potential economic value from the tourism sector. This study aims to determine the economic value of the Umbul Sidomukti tourist attraction based on the travel cost method (TCM). This study uses the travel cost method based on primary data from in-person interviews and online surveys with 105 visitors visiting the Umbul Sidomukti tourist area. The study results show that the relationship between travel costs and distance and the number of tourist visits has a ceteris paribus negative relationship following tourism demand. Service and income variables have a positive effect that is not significant. Meanwhile, the potential economic value of the Umbul Sidomukti tour is estimated at Rp. 28,142,763,075 per year. This research can be used to develop natural tourism objects using the travel cost approach, especially the Umbul Sidomukti tourism object.
PENGARUH PROFITABILITAS, KEPEMILIKAN INSTITUSIONAL, DAN KEPEMILIKAN MANAJERIAL TERHADAP NILAI PERUSAHAAN BEI 2019-2021
Authors: Adinata I Kadek Agus Krisna , Riasning Ni Putu , Kawisana Putu Gede Wisnu Permana 
Published: March 2024

Tujuan utama perusahaan yang sudah go public (perusahaan yang sahamnya tercatat di Bursa Efek Indonesia) yaitu untuk menghasilkan keuntungan atau profit guna meningkatkan nilai perusahaan. Penelitian ini bertujuan untuk mengetahui pengaruh profitabilitas, kepemilikan institusional, dan kepemilikan manajerial terhadap nilai perusahaan. Penelitian ini dilakukan pada perusahaan sektor perdagangan, jasa, dan investasi yang terdaftar di Bursa Efek Indonesia periode 2019-2021, dengan jumlah sampel 105 perusahaan. Pengumpulan data pada penelitian ini dilakukan dengan metode purposive sampling. Teknis analisis data pada penelitian ini menggunakan analisis regresi linear berganda. Berdasarkan analisis diperoleh hasil bahwa profitabilitas berpengaruh positif dan tidak signifikan terhadap nilai perusahaan, kepemilikan institusional berpengaruh negatif dan signifikan terhadap nilai perusahaan, sedangkan kepemilikan manajerial berpengaruh positif dan signifikan terhadap nilai perusahaan.
Apresentação de Dossiê: A virada de gênero na historiografia brasileira: pesquisas, temáticas e debates
Authors: Pedro Joana Maria , Souto Maior Júnior Paulo Roberto 
Published: March 2024

Desde que o texto Gênero: uma categoria útil de análise histórica, da historiadora Joan Scott, foi traduzido e publicado, em 1990, pela revista Educação e Realidade, abriu-se um campo oportuno para desenvolver pesquisas sobre o tema na historiografia brasileira. Entre experimentações, resistências e novos olhares para os arquivos, se tornou possível conhecer as experiências de sujeitos até então silenciados. Nesse sentido, o presente dossiê tem por objetivo pensar os impactos que os estudos de gênero causaram na historiografia brasileira nas últimas décadas. Como uma reflexão teórica, essa área de conhecimento alterou o modo como analisamos a constituição dos arquivos, a crítica documental, o contexto dos nossos objetos de pesquisa e a leitura do passado. Tais reflexões possuem também uma dimensão política ancorada na ideia, dentre outras, de que visibilidade importa. Partindo desses pressupostos, discentes de cursos de História cobram que professores coloquem nos seus programas de cursos autoras e mulheres negras. A formação inicial de professores de História, de modo semelhante, produz discussões sobre relações de gênero e sexualidade no âmbito da história ensinada. Coletâneas, dossiês, artigos em revista, livros mostram que historiadoras e historiadores descobriram, questionam, produzem e experimentam os estudos de gênero. Acreditamos que chegou o momento de nos unirmos para pensar essa trajetória, sobretudo num momento de tamanho ataque à essa área de pesquisa, atentando para o seu percurso, as resistências, as tensões dos estudos de gênero com diferentes correntes historiográficas, os usos de conceitos, a influência de pensadoras no nosso modo de questionar, pensar e escrever sobre o passado.
Immunological Remission as a Basis for Dose Reduction of Immunosuppressors in Autoimmune Hepatitis: Results of Monocenter Surveillance Study
Authors: Bueverov A. O. , Koblov S. V. , Bogomolov P. O. 
Published: March 2024

Aim of the study: evaluate the role of normalization of humoral immunity to address dose reduction or discontinuation of immunosuppressors in patients with autoimmune hepatitis (AIH).Patients and methods. The data of 47 patients with AIH who received immunosuppressive therapy from April 2001 to August 2023 were analyzed: 10 men (21 %), 37 women (79 %); the average age was 37 (17–66) years. The follow-up period was 10–180 months. Type 1 AIH was diagnosed in 37 patients, type 2 AIH — in 7 patients, seronegative AIH — in 3 patients. The diagnosis was established according to the IAIHG point system. To confirm the diagnosis, a liver biopsy was performed in 17 patients, a histological picture of AIH was detected in all of them. The most used combination was prednisolone and azathioprine — in 25 patients (53.2 %), as well as methylprednisolone and azathioprine — in 8 patients (17 %).Results. In some patients, when the immunosuppressive therapy decreased below the recommended dose, a relapse of the disease developed (Group 1), and in others, remission persisted (Group 2). The concentration of гамма-globulins in patients of Group 1 was 22.5 mg%, in Group 2 — 17.95 mg% (p = 0.00055). IgG level after achieving remission in Group 1 was 1709.7 mg/dL, in Group 2 — 1381.7 mg/dL (p = 0.000001). The terms of ALT normalization in Group 1 were 2.14 months, in Group 2 — 1.47 months (p = 0.037); AST normalization in Group 1 made 2.22 months, in Group 2 — 1.48 months (p = 0.026).Conclusions. Normalization of humoral immunity, as well as rapid normalization of ALT and AST can be considered as markers of maintaining AIH remission when immunosuppressor doses are reduced below standard doses, and in individual patients — the possibility of immunosuppressive therapy withdrawal. This will reduce the risk of adverse events and increase adherence to the therapy. We propose introducing the term “immunological remission” into the clinical lexicon, which, along with biochemical and histological remission, acts as a predictor of persistent remission of AIH.
Pathogenesis of Functional Biliary Pain and Pharmacology of Trimebutin
Authors: Bueverova E. L. , Zolnikova O. Yu. , Dzhakhaya N. L. , Sedova A. V. , Ivashkin V. Т. 
Published: March 2024

Aim: to provide data on the pathogenesis of functional biliary pain and provide rationale for the use of trimebutine for this indication.Key points. Biliary pain is one of the most frequent reasons for patients to see a doctor. The diagnosis of functional disorder of the gallbladder and Oddi's sphincter is legitimate only after the exclusion of organic causes from both the gastrointestinal tract and other organs and systems. The initial appeal to surgeons with a complaint of pain in the epigastrium or right hypochondrium may lead to unjustified surgical intervention that does not bring relief to the patient's suffering. The consequences of cholecystectomy also have an anatomical and physiological justification for the occurrence or preservation of biliary pain. Currently, two main hypotheses are being considered to explain its cause: increased intraluminal pressure due to morphological and functional obstacles to bile outflow and visceral hypersensitivity. In the multilevel system of regulation of the gallbladder and sphincter apparatus, the opioid system occupies a special place. The agonist of peripheral receptors of the enkephalinergic system, trimebutine, in clinical studies led to the relief of biliary pain in more than 80 % of patients with functional biliary disorders, while a significant decrease in the severity of diarrhea, dyspeptic, and constipation syndromes was revealed.Conclusion. The prescription of the peripheral receptor agonist of the enkephalinergic system, trimebutine, is pathogenetically justified for functional biliary pain.
The Generic Mapping Tools and Animations for the Masses
Authors: Wessel Paul , Esteban Federico Damián , Delaviel-Anger Guillaume 
Published: March 2024

-The Generic Mapping Tools (GMT) is a well-known set of software
originally developed for geosciences, allowing scientists in climate and
solid earth disciplines to routinely create publish-ready maps and
graphics. However, GMT users rarely make animations despite their
undeniable benefit for understanding and teaching dynamical processes.
As reading habits shift from print to digital, capitalizing on
animations for illustrating scientific concepts is more accessible than
ever. In the latest GMT version (6.5) we have added and refined the
moving-making modules, alleviating the time-consuming steps that would
hinder GMT users from making such animations. In this paper we will
explain how GMT ”movie” works then provide six representative
examples, from basic to more advanced, to show some of its key features.
We hope our presentation will encourage the masses to routinely create
animations for their publications.

See videos
at: https://youtube.com/playlist?list=PL3GHXjKa-p6VdPql5aReLQZeQDJgWDAY-
Kontekstualisasi Hukum Waris di Indonesia: Tinjauan Maqashid Syari’ah terhadap Hak Waris Ayah pada Pasal 177 Kompilasi Hukum Islam
Authors: Norhayati Norhayati , Anshary Hafiz , Umar Masyitah 
Published: March 2024

This article aims to analyze the renewal of Islamic inheritance law in the Compilation of Islamic Law (KHI) regarding inheritance rights for fathers from the perspective of ijtihad, maslahah, and maqashid sharia. This study is a part of legal research using the library method. The approach used in this study is historical and juridical normative. The data obtained were then analyzed with the interactive qualitative analysis of the Miles and Huberman model, namely data reduction, data verification, and concluding. This study found that the provision of the father's inheritance was rejected as a valid product of ijtihad. Viewed from the perspective of maqashid al-syar'iyyah, this provision does not at all try to maintain the five basic principles above, both the maintenance of religion (din), soul (nafs), reason (aqal), offspring (nasab), property (mal). On the other hand, these provisions only bring harm.Keywords: Compilation of Islamic Law; Father inheritance share; Inheritance Law
Translation Principles in Modern Cognitive Paradigm
Authors: Olenev S. V. , Kushnina L. V. , Permyakova K. V. 
Published: March 2024

The article discusses the cognitive-communicative principles of modern translation studies based on the cognitive paradigm, which focuses on the cognitive activities of translators and the information, knowledge, and meanings contained in texts and discourses. The aim of the research is to develop principles of translation studies from the perspective of this paradigm. The research methodology is based on the author’s concept of translation space, which operates with the concepts of cognition, synergy, and harmony; the concept of “epistemic situation,” which reveals the extralinguistic semantic basis of scientific texts as a triad of ontology, methodology, and axiology; and cognitive studies of language and translation. The methodological approach to the practical analysis of translation implemented in the article is based on the principles of synergy, which reveal the regularities of complex linguo-cognitive systems. The axiological orientation of translation is based on the idea of harmony as a semantic proportionality, which serves as a criterion for translation quality. Fragments of texts from the scientificphilosophical discourse of Roland Barthes and Michel Foucault in Russian and French served as empirical material for analyzing how the principles of translation studies work. As a result of the research, anthropocentric, epistemological, and reflexive-conceptual principles of translation studies are characterized.
Financial Constitution Issues in Development of the Basic Law for the Federal Republic of Germany in 1948-1949
Authors: Popov I. D. 
Published: March 2024

This article analyzes the key problems of the financial constitution in the development of the Basic Law for the Federal Republic of Germany (FRG) in 1948-1949, based on materials from the Constitutional Convention at Herrenchiemsee and the Parliamentary Council of West Germany. It emphasizes that the relevance of this issue was influenced by Germany’s historical development, which had a long-standing experience in both regional and imperial financial administration. This led to high significance of financial constitution issues in post-war West German politics. It is concluded that the main approaches to this problem were developed at the Herrenchiemsee Convention in October 1948, and the main content of the financial section of the Basic Law was formulated in the financial committee at the beginning of October 1948. A key role in developing the financial constitution was played by parliamentarian H. HöpkerAschoff. However, until May 1949, the parties could not reach a consensus on matters of financial administration system and financial equalization. This was significantly influenced by constant objections from the occupying administrations, the position of the Christian Social Union in Bavaria (CSU), uncertainty in assessing financial conditions, and the Social Democrats’ consistent defense of broad financial powers for the federal center.
Corruption Prevention of Village Funds to Realize Anti-Corruption Village
Authors: Judy Marria Saimima  , Juanrico A.S. Titahelu  , Patrick Corputty  , Muammar  
Published: March 2024

Abstract
This paper aims to describe and analyze how the form of corruption prevention of village funds can ideally be carried out to realize an anti-corruption village. This paper uses a normative type of research. The approach used in this paper is a conceptual approach (conceptual approach) and an analytical approach (analytical approach). The discussion in the paper presents that so far the eradication of corruption has focused more on the downstream region by relying on criminal legal means. the eradication of corruption should ideally be pursued optimally in the most upstream areas, namely prevention areas. This includes efforts to prevent corruption of village funds, which have often become "soft food" for irresponsible village government elements and village officials. For this reason, efforts that should be done include. First, seek community participation and active role in the discussion, management, and use of village funds; second, strengthening governance to prevent corrupt practices; third, strengthening supervision, especially regarding village governance; fourth, strengthening the quality of public services to gain full trust from the public and provide feedback instruments to determine public satisfaction with the performance performed; Fifth, strive for the empowerment of local wisdom that applies in the village, such as the role of customary law or local culture and encourage the involvement of various elements such as religious leaders, traditional leaders, community leaders, youth communities.
Keywords: Corruption Prevention; Village Fund; Anti-corruption