bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diabetes Pharmacotherapy and its effects on the Skeletal Muscle Energy
Metabolism
Authors: Yu Baowen , Wang Dong , Zhou Junming , Huang Rong , Cai Tingting , Hu Yonghui , Zhou Yunting , Ma Jianhua 
Published: March 2024

Abstract:
The disorders of skeletal muscle metabolism in patients with Type 2 diabetes mellitus
(T2DM), such as mitochondrial defection and glucose transporters (GLUTs) translocation dysfunctions,
are not uncommon. Therefore, when anti-diabetic drugs were used in various chronic diseases
associated with hyperglycemia, the impact on skeletal muscle should not be ignored. However, current
studies mainly focus on muscle mass rather than metabolism or functions. Anti-diabetic drugs
might have a harmful or beneficial impact on skeletal muscle. In this review, we summarize the upto-
date studies on the effects of anti-diabetic drugs and some natural compounds on skeletal muscle
metabolism, focusing primarily on emerging data from pre-clinical to clinical studies. Given the
extensive use of anti-diabetic drugs and the common sarcopenia, a better understanding of energy
metabolism in skeletal muscle deserves attention in future studies.
Neferine Targeted the NLRC5/NLRP3 Pathway to Inhibit M1-type Polarization and Pyroptosis of Macrophages to Improve Hyperuricemic Nephropathy
Authors: Yin Wei , Wang Jin-Hua , Liang Yu-Mei , Liu Kang-Han , Chen Ying , Chen Yusa 
Published: March 2024

Background:
Neferine (Nef) has a renal protective effect. This research
intended to explore the impact of Nef on hyperuricemic nephropathy (HN).

Methods:
Adenine and potassium oxonate were administered to SD rats to induce the
HN model. Bone marrow macrophages (BMDM) and NRK-52E were used to construct
a transwell co-culture system. The polarization of BMDM and apoptosis levels were
detected using immunofluorescence and flow cytometry. Renal pathological changes
were detected using hematoxylin-eosin (HE) and Masson staining. Biochemical
methods were adopted to detect serum in rats. CCK-8 and EDU staining were used to
assess cell activity and proliferation. RT-qPCR and western blot were adopted to
detect NLRC5, NLRP3, pyroptosis, proliferation, and apoptosis-related factor levels.

Results:
After Nef treatment, renal injury and fibrosis in HN rats were inhibited, and
UA concentration, urinary protein, BUN, and CRE levels were decreased. After Nef
intervention, M1 markers, pyroptosis-related factors, and NLRC5 levels in BMDM
stimulated with uric acid (UA) treatment were decreased. Meanwhile, the proliferation
level of NRK-52E cells co-cultured with UA-treated BMDM was increased, but the
apoptosis level was decreased. After NLRC5 overexpression, Nef-induced regulation
was reversed, accompanied by increased NLRP3 levels. After NLRP3 was knocked
down, the levels of M1-type markers and pyroptosis-related factors were reduced in
BMDM.

Conclusion:
Nef improved HN by inhibiting macrophages polarized to M1-type and
pyroptosis by targeting the NLRC5/NLRP3 pathway. This research provides a scientific
theoretical basis for the treatment of HN.
WITHDRAWN: Resveratrol-based Delivery Systems as Contemporary Nominees for Combating Pulmonary Diseases: A Comprehensive Review
Authors: Ahmed Sara , Mansour Mai , Ishak Rania A.H. , Mortada Nahed D. 
Published: March 2024

Abstract:
Since the authors are not responding to the editor’s requests to fulfill the editorial requirement, therefore, the article has been
withdrawn of the journal "Current Drug Delivery".
Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.
The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php.
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of their article is transferred to the publishers if and when the article is accepted for publication.
Efficacy and Safety of Nimotuzumab in Combination with Radiotherapy
or Chemoradiotherapy for Local Advanced Head and Neck Cancer: A
Systematic Review and Meta-analysis
Authors: Zheng Baomin , He Meilin , Han Yaqian , Jiang Xin , Ou Xiaomin , Zhang Peng , Guo Ruyuan , Li Jingao , Zhang Ximei , Qiao Qiao , Wu Hui , Hu Man , Feng Mei , Tu Wenyong , Yi Junlin 
Published: March 2024

Background:
The present meta-analysis aimed to evaluate the efficacy and safety of adding
nimotuzumab to radiotherapy (RT) or chemoradiotherapy (CRT).

Methods:
Prospective randomized controlled studies at EMBASE, PubMed, and the Cochrane Library
from January 1, 2010, to October 1, 2022, were searched. Data on the overall survival (OS),
progress-free survival (PFS), disease-free survival (DFS), complete response rate (CRR), objective
response rate (ORR), and all grade adverse events were collected from the enrolled publications.
OS was the primary measurement indicator. Pooled analysis was performed with relative
risks (RRs), hazard risks (HRs), and their corresponding 95% confidence intervals (CIs) in the
software Stata SE 16.0.

Results:
Six randomized controlled studies were included in the analysis of the overall pooled effect.
As compared to the control group, the nimotuzumab intervention group exhibited improved
OS by 21% (pooled HR=0.79,95% CI: 0.64-0.98, P=0.028), along with PFS up to 31% (HR=0.69,
95% CI: 0.55-0.86, P=0.001) and DFS up to 29% (HR=0.71, 95% CI: 0.56-0.91, P=0.006), increased
CRR as 50% (RR=1.50, 95% CI:1.09-2.04; P=0.012), and ORR as 35% (RR=1.35, 95%
CI:1.04-1.73; P=0.022). Regarding safety, nimotuzumab in combination with RT or CRT did not
increase the incidence of all grade adverse events (pooled-RD=-1.27, 95% CI:-2.78-0.23,
P=0.099).

Conclusion:
The present meta-analysis has demonstrated that nimotuzumab, in combination with
RT or CRT, could provide survival benefits and increase response rates. Its safety profile has been
found to be controllable.
Discovery of Ten Anti-HIV Hit Compounds and Preliminary
Pharmacological Mechanisms Studies
Authors: Lian Yushan , Huang Zhimin , Liu Xinyi , Deng Zhicheng , Gao Dan , Wang Xiaohui 
Published: March 2024

Background:
The research and development of HIV drugs is very important, but at the
same time it is a long cycle and expensive system project. High-throughput drug screening systems
and molecular libraries of potential hit compounds remain the main ways for the discovery
of hit compounds with anti-HIV activity.

Objective:
The aim of this study was to screen out the hit compounds against HIV-1 in the natural
product molecule library and the antiviral molecule library, and elucidate the molecular mechanism
of their inhibition of HIV-1, so as to provide a new choice for AIDS drug research.

Methods:
In this study, a drug screening system using HIV Rev-dependent indicator cell line
(Rev-A3R5-GFP reporter cells) with pseudoviruses (pNL4-3) was used. The natural drug
molecule library and antiviral molecule library were screened, and preliminary drug mechanism
studies were performed.

Results:
Ten promising hit compounds were screened. These ten molecules and their drug inhibitory
IC50 were as follows: Cephaeline (0.50 μM), Yadanziolide A (8.82 μM), Bruceine D (2.48
μM), Astragaloside IV (4.30 μM), RX-3117 (1.32 μM), Harringtonine (0.63 μM), Tubercidin
(0.41 μM), Theaflavine-3, 3'-digallate (0.41 μM), Ginkgetin (10.76 μM), ZK756326 (5.97 μM).
The results of the Time of additions showed that except for Astragaloside IV and Theaflavine-3,
3'-digallate had a weak entry inhibition effect, and it was speculated that all ten compounds had
an intracellular inhibition effect. Cephaeline, Harringtonine, Astragaloside IV, Bruceine D, and
Tubercidin may have pre-reverse transcriptional inhibition. Yadanziolide A, Theaflavine-3, 3'-digallate,
Ginkgetin and RX-3117 may be in the post-reverse transcriptional inhibition. The inhibitory
effect of ZK 75632 may be in the reverse transcriptional process.

Conclusion:
A drug screening system using Rev-A3R5-GFP reporter cells with pseudoviruses
(pNL4-3) is highly efficient. This study provided potential hit compounds for new HIV drug
research.
Evaluation of Mex A' Mex B Efflux Pump Gene in Pseudomonas aeruginosa Isolated from Milk in Qom Province, Iran
Authors: Badi Alireza , Dirbaziyan Ashkan , Shakib Pegah , Morovvati Abbas , Zargar Mohsen 
Published: March 2024

Background:
Pseudomonas aeruginosa is an opportunistic pathogen protected from
antibiotics' harmful effects by various mechanisms. One of the most important mechanisms is the
activation of exudation systems. Therefore, identifying such targets in food contaminating bacteria
can help us target them and eliminate bacteria resistant to several drugs, making food safe. Therefore,
the present study aimed to trace Mex A and Mex B efflux pump genes in Pseudomonas
aeruginosa isolated from dairy products in Qom City, Iran.

Methods:
300 samples of raw milk, 30 samples of pasteurized milk, and 30 samples of local
cream were collected. After a 24-hour culture on nutrient agar and blood agar and performing
warm staining, confirmatory biochemical tests were performed to identify bacteria. The disk
method was used according to CLSI guidelines to determine the antibiotic sensitivity pattern.
Then Mex A and Mex B efflux pump genes were detected using specific primers with PCR technique.

Results:
117 strains of Pseudomonas aeruginosa were isolated from 300 raw milk samples, and 7
strains were resistant to ciprofloxacin. Out of 117 Pseudomonas aeruginosa isolates, 51 isolates
(43.5%) had Mex A gene and 10 isolates (8.5%) had Mex B gene. Three isolates had both Mex A
and Mex B genes. Among the strains with resistance to ciprofloxacin (7 isolates), 4 isolates did not
have any of the genes. One isolate had Mex A and Mex B genes; 2 isolates were Mex A positive
and Mex B negative, and Mex B positive and Mex A negative isolates were not observed.

Conclusions:
Based on the results, among the studied isolates, the Mex A gene was more abundant.
In addition, no significant relationship was found between the existence of Mex A and Mex B
genes and ciprofloxacin resistance.
A Review of Minimally and Non-invasive Glucose Monitoring Techniques,
Devices and Sensors
Authors: Nooshnab Mohammad , Naghib Seyed Morteza , Rahmanifard Rouhollah , Khakpour Elnaz 
Published: March 2024

Abstract:
Glucose determination, without pain and aches, is essential for biomedical applications.
Minimally invasive (MI) and non-invasive (NI) are the approaches that could address these challenges.
MI approaches are based on body fluids such as saliva, urine, tears, and interstitial fluid that are
exploited to determine glucose levels. NI methods utilize radiation forms to determine glucose
concentration without needing body fluids. In this review, MI and NI technologies and their application
in glucose measurement, along with current and future devices that use these technologies, are
described and discussed. Also, the principles and requirements and operational and analytical
performance will be reviewed and discussed.
Anti-Inflammatory and Wound Healing Potential of Comphora Wightii,Herbal Ointment on Wistar Rats
Authors: Garg Ishu , Singh Neelam , Sharma Ishika , Dhingra Jayeeta , Kumar Kartik 
Published: March 2024

Background:
A herbal approach to Guggulu (Commiphora wightii), as an anti-inflammatory
and wound healing agent is anticipated. Phyto-constituents Guggulusterone, Naringenin, and
myrrhanol were reported for the anti-inflammatory activity of Guggulu. Studies suggests, that sesame
oil (Sesamum indicum L.) and Ratanjot (Arnebia nobilis) also act as potent anti-inflammatory agents..
A combination of all three of these gives a synergistic effect for anti-inflammatory and excisional
wound healing activity.

Materials and Methods:
A simple ointment base, BP and 5% Ratanjot, and Sesame oil were prepared.
All the components, i.e., Guggulu, 5% Ratanjot Sesame oil, and simple ointment base, were added
and triturated uni-directionally until a smooth, homogenous mixture was obtained. 25% w/w (F1) and
27% w/w (F2) Guggulu ointment were prepared. Four groups, each with three wistar rats, were studied
for fourteen days. On the fourteenth day, rats were sacrificed, and tissues were collected for histopathological
studies.

Results:
F1 was compared against the standard formulation (10% w/w betadine, Win-Medicare) for
excisional wound healing and anti-inflammatory activity in rats. On the foutheenth day, the results
for percentage wound contraction in groups 1 (Negative control, vaseline), 2 (Controlled, ointment
base), 3 (F1), and 4 (positive control, standard) were found to be 12.01, 25.32, 96.14, and 81.23,
respectively. Results of histopathological studies and H&E staining supported the action of F1, as
skin sections showed the junction of normal skin and wound area. Sub-epithelial tissues showed low
(-) to mild (+) inflammation. Mild oedema (+) was also noted.

Conclusion:
The rat group treated with F1 showed maximum wound contraction, healing, and antiinflammatory
activity as per percentage wound contraction and histopathological studies.
Comparative Evaluation of Cefixime Microspheres Utilizing a Natural Polymer and a Synthetic Polymer
Authors: Arora Deepshi , Taneja Yugam , Sharma Anjali , Sharma Prerna , Jatin  , Guarve Kumar , Rani Nidhi , Verma Inderjeet 
Published: March 2024

Background:
Microspheres are naturally biodegradable, free-flowing powders with a particle
size of less than 200 micrometres that are comprised of proteins or synthetic polymers. Using
microspheres is a reliable strategy to ensure that the drug is accurately delivered to the target area and
that the right concentration is kept there without having any unfavourable side effects.

Objective:
The objective of the present study was to create a sustained-release cefixime trihydrate
microsphere delivery system employing natural and synthetic polymers as a carrier and increase therapeutic
effectiveness.

Methods:
Due to the simplicity of processing, the solvent injection method was used to create microspheres.
Microspheres were created with this technology using the sustained-release polymer, sodium
alginate, and active material (drug). The compatibility of components with the drug was evaluated
using XRD and FT-IR. In an in-vitro release research, the dissolving medium was phosphate buffer
at pH 6.8. For the kinetic analysis of the drug release mechanism, graphs for zero-order, first-order,
Higuchi's, Korsmeyer-Peppas, and Hixson-Crowell models were also created.

Results:
The best formulation was chosen from the batches, and in-vitro cefixime trihydrate release
studies for various microspheres containing cefixime trihydrate in phosphate buffer (pH 7.4) for 8
hours were performed. The dissolution profiles of formulations F4 and F8 showed that the formulation,
including xanthan gum, F8, released 55.01% more medication in 8 hours than the formulation
using HPMC, F4. X-ray diffraction, swelling index of drug-laden microspheres, and Scanning Electron
Microscopy were used to evaluate formulation F8. The graphs for zero-order, first-order, Higuchi's,
Korsmeyer-Peppas, and Hixson- Crowell models were plotted, and the optimised batch was
discovered to match Higuchi's drug release kinetics with an R2 value of 0.990.

Conclusion:
Cefixime trihydrate microspheres can be utilized as a new drug delivery technology to
minimize dose frequency and, as a result, to promote patient compliance.
Study of Selected Patents on the Manufacture of Activated Carbon
as Electrodes in Power Storage Devices
Authors: Javed Khan Farahat , Kokane Sonali Sandeep 
Published: March 2024

Abstract.:
The field of activated carbon has attracted many researchers. Our study of selected
patents on the mentioned subject reveals an interesting fact, such as including the
pore characteristics of the electrode material in the claims of a patent specification. The
parameters, such as power density, energy density, capacitance and charge-recharge cycles,
are mentioned for the various embodiments in the patent specification. The technolegal
aspects of patenting in this field are concerned with the source of the carbon, the active
material with which it is composited or activated, the process of treatment, which includes
time, temperature and method, the resulting energy storage device, and the process
of making such a device.
PLASTAMINATION: Outcomes on the Central Nervous System and
Reproduction
Authors: Santoro Antonietta , Marino Marianna , Vandenberg Laura N. , Szychlinska Marta Anna , Lamparelli Erwin Pavel , Scalia Federica , Rocca Natalia Della , D’Auria Raffaella , Giovanna Pastorino Grazia Maria , Porta Giovanna Della , Operto Francesca Felicia , Viggiano Andrea , Cappello Francesco , Meccariello Rosaria 
Published: March 2024

Background:
Environmental exposures to non-biodegradable and biodegradable plastics
are unavoidable. Microplastics (MPs) and nanoplastics (NPs) from the manufacturing of plastics (primary
sources) and the degradation of plastic waste (secondary sources) can enter the food chain directly
or indirectly and, passing biological barriers, could target both the brain and the gonads. Hence, the
worldwide diffusion of environmental plastic contamination (PLASTAMINATION) in daily life may
represent a possible and potentially serious risk to human health.

Objective:
This review provides an overview of the effects of non-biodegradable and the more recently
introduced biodegradable MPs and NPs on the brain and brain-dependent reproductive functions,
summarizing the molecular mechanisms and outcomes on nervous and reproductive organs. Data from
in vitro, ex vivo, non-mammalian and mammalian animal models and epidemiological studies have
been reviewed and discussed.

Results:
MPs and NPs from non-biodegradable plastics affect organs, tissues and cells from sensitive
systems such as the brain and reproductive organs. Both MPs and NPs induce oxidative stress, chronic
inflammation, energy metabolism disorders, mitochondrial dysfunction and cytotoxicity, which in turn
are responsible for neuroinflammation, dysregulation of synaptic functions, metabolic dysbiosis, poor
gamete quality, and neuronal and reproductive toxicity. In spite of this mechanistic knowledge gained
from studies of non-biodegradable plastics, relatively little is known about the adverse effects or molecular
mechanisms of MPs and NPs from biodegradable plastics.

Conclusion:
The neurological and reproductive health risks of MPs/NPs exposure warrant serious
consideration, and further studies on biodegradable plastics are recommended.
THE IMPACT OF ATRIAL FIBRILLATION ON THE COURSE OF HEART FAILURE: FOCUS ON DIASTOLIC FUNCTION AND BIOMARKERS
Authors: Kulaiets N.M. 
Published: March 2024

Серцева недостатність зі збереженою фракцією викиду (СНзбФВ) та фібриляція передсердь (ФП) - тісно пов'язані між собою серцево-судинні захворювання. Їх складна взаємодія та спільні фактори ризику ускладнюють лікування.
Мета – дослідити взаємозв'язок між діастолічною дисфункцією та рівнями серцевих біомаркерів (NT-proBNP, ST2 та галектину-3) у пацієнтів із серцевою недостатністю зі збереженою фракцією викиду та оцінити прогностичну цінність цих біомаркерів у діагностиці та оцінці тяжкості діастолічної дисфункції.
Матеріали і методи. Дослідження проводилося як одноцентрове когортне дослідження на базі Івано-Франківського обласного клінічного кардіологічного центру, а матеріали та методи, що використовувалися, описані нижче. Пацієнти були розподілені на дві групи: одна - лише з СНзбФВ (41 пацієнт), інша - з СНзбФВ та фібриляцією передсердь (ФП) (64 пацієнти).
Результати. Аналіз показав достовірні відмінності ехокардіографічних параметрів та біомаркерів між двома групами. Пацієнти як з СНзбФВ, так і з ФП мали більш виражені ехокардіографічні ознаки збільшення та дисфункції лівого передсердя. Аналіз біомаркерів виявив вищі рівні NT-proBNP, sST2 і галектину-3 у пацієнтів з СНзбФВ і ФП порівняно з пацієнтами лише з ГЛШ, що вказує на більш тяжкий клінічний перебіг. Результати дослідження дозволяють зробити впевнений висновок, що ФП має значний вплив на прогресування та тяжкість перебігу СНзбФВ.
Висновки:

sST2 є ключовим показником, оскільки його сильна кореляція з наявністю ФП у пацієнтів із СНзбФВ дозволяє з високою точністю визначити вираженість міокардіального стресу.
Негативні кореляції Deceleration time та ФВ ЛШ у групі СНзбФВ + ФП вказують на більш виражену діастолічну та систолічну дисфункцію у цій групі, що свідчить про необхідність пошуку таргетних стратегій ведення цих пацієнтів.
Позитивна кореляція між LAVI і біомаркерами міокардіального стресу свідчить про те, що збільшення передсердь є важливим фактором, який впливає на ступінь тяжкості СНзбФВ, особливо у пацієнтів з ФП.
Patient Perspectives on Communication Pathways After Orthopedic Surgery and Discharge and Evaluation of Team-Based Digital Communication: Qualitative Exploratory Study
Authors: Jensen Lili Worre Høpfner , Rahbek Ole , Lauritsen Rikke Emilie Kildahl , Kold Søren , Dinesen Birthe 
Published: March 2024

Background
The transition from hospital to home after orthopedic surgery requires smooth communication and coordination between patients and their team of care to avoid fragmented care pathways. Digital communication is increasingly being used to facilitate easy and accessible asynchronous communication between patients and health care professionals across settings. A team-based approach to digital communication may provide optimized quality of care in the postoperative period following orthopedic surgery and hospital discharge.

Objective
This study was divided into two phases that aimed to (1) explore the perspectives of patients undergoing orthopedic surgery on current communication pathways at a tertiary hospital in Denmark and (2) test and explore patients’ experiences and use of team-based digital communication following hospital discharge (eDialogue).

Methods
A triangulation of qualitative data collection techniques was applied: document analysis, participant observations (n=16 hours), semistructured interviews with patients before (n=31) and after (n=24) their access to eDialogue, and exploration of use data.

Results
Findings show that patients experience difficult communication pathways after hospital discharge and a lack of information due to inadequate coordination of care. eDialogue was used by 84% (26/31) of the patients, and they suggested that it provided a sense of security, coherence, and proximity in the aftercare rearranging communication pathways for the better. Specific drivers and barriers to use were identified, and these call for further exploration of eDialogue.

Conclusions
In conclusion, patients evaluated eDialogue positively and suggested that it could support them after returning home following orthopedic surgery.