bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mental Health Challenges Among Children and Adolescents Associated With HIV Status Disclosure: A Systematic Review and Meta-Analysis Protocol
Authors: Kirabira Joseph , Zanoni Christopher Brian , Etoko Christine Atala , Katongole Fauz , Etoko Naume Akello , Rukundo Godfrey Zari , Kinengyere Alison Annet , Lwere Kamada , Byakwaga Helen , Wakida Edith , Ashaba Scholastic , Obua Celestino 
Published: March 2024

BACKGROUND: Prenatally acquired HIV is highly prevalent among children and adolescents globally. HIV status disclosure to children is recommended to start from 8 years and older and has shown several benefits. However, HIV status disclosure is also associated with high risks of mental health challenges. This review and meta-analysis aim at describing the prevalence of mental health challenges and associated factors among children and adolescents living with HIV.

METHODS: The study will involve conducting a systematic review and meta-analysis of the existing literature on the burden of mental health challenges including stigma, depression, anxiety and suicidality after HIV status disclosure among children and adolescents aged 8-17 years. Searches for both observational and interventional studies will be performed in PubMed, Medline, Embase, CINAHL and APA Psych Info from 2000 to the date of the review. Statistical heterogeneity will be assessed using I2 test and visual inspection of the forest plot. Data will be extracted using an investigator designed data extraction form by two independent people and any disagreements will be solved by involving a third person. Using the RevMan software, a random effects model will be applied to calculate a standardised mean estimate of the prevalence of mental health challenges. A narrative will be presented for the factors associated with the mental health challenges. Risk of bias will be assessed using the appropriate study design tool and results will be reported following the PRISMA 2015 guidelines.

CONCLUSION: The review will provide valuable results that will shed light on the burden of mental health challenges associated with HIV status disclosure and the influencing factors among children and adolescents. This will inform clinical practice about the importance of assessing and managing the challenges according as well as designing health policies regarding the same.
PENGARUH KOMPOSISI BEKATUL DAN AMPAS TAHU TERHADAP PERTAMBAHAN BOBOT BADAN DOMBA EKOR TIPIS
Authors: Nugraha Nova Abda , Trisnaningsih Umi , Subandi Subandi 
Published: March 2024

ABSTRAKPenelitian ini bertujauan untuk mendapatkan komposisi ampas tahu dan bekatul yang terbaik sebagai pakan konsentrat untuk penggemukan domba ekor tipis. Penelitian dilaksanakan di KTTD Karya Kinasih Desa Bakung Kidul Kecamatan Jamblang kabupaten Cirebon selama 14 hari, yaitu 27 januari-9 febuari 2009.Penelitian dilakaukan dengan mengguanakan 24 ekor domba yang memiliki berat anatara 24,0-30,0 kg yang diberi pakan dengan komposisi 10 % rumput alam dan 1 % konsentrat dari berat badan domba. PenelitianÂ menggunakan metode eksperimen dengan rancangan acak lengkap dengan 6 perlakuan dan 4 Kali ulangan. Apabila terjadi perbedaan nyata dilanjutkan dengan uji jarak berganda duncan.Perlakuan yang digunakan dalam penelitian ini adalah:Perlakuan A: 90 %Â ampas tahu 10 % bekatul, protein harian pakan 0,125 kg, Perlakuan B : 80 % ampas tahuÂ 80 % bekatul, protein harian pakan 0,133 kg, Perlakuan C : 70 % ampas tahuÂ 30 %Â bekatul, protein harian pakan 0,139 kg, Perlakuan D : 60 % ampas tahuÂ 40 %Â bekatul, protein harian pakan 0,145 kg, Perlakuan E : 50 % ampas tahuÂ 50 %Â bekatul, protein harian pakan 0,152kg, Perlakuan F : 40 % ampas tahuÂ 60 %Â bekatul, protein harian pakan 0,159 kg.Penelitian ini mendapatkan kesimpulan bahwa komposisi konsentrat denganberbahan 60% ampas tahu 40% bekatul memberikan pertambahan berat badan harian terbaik pada domba ekor tipis, yaitu 0,1850 kg perhari dengan pertambahan berat badan domba dalam dua minggu ( akhir penelitian) 2,5850 kg.Kata Kunci : Domba, Bobot badan dan pakan bekatul
Sugar Utilization-Associated Food-Grade Selection Markers in Lactic Acid Bacteria and Yeast
Authors: Liang Zhiwen , Zheng Ke , Xie Guifeng , Luo Xiongsheng , Li Huangjin 
Published: March 2024

Abstract
This comprehensive review explores the development of food-grade selection markers in lactic acid bacteria and yeast; some of their strains are precisely defined as safe microorganisms and are crucial in the food industry. Lactic acid bacteria, known for their ability to ferment carbohydrates into lactic acid, provide essential nutrients and contribute to immune responses. With its strong fermentation capabilities and rich nutritional profile, yeast finds use in various food products. Genetic engineering in these microorganisms has grown rapidly, enabling the expression of enzymes and secondary products for food production. However, the focus is on ensuring safety, necessitating food-grade selection markers. Traditional antibiotic and heavy metal resistance selection markers pose environmental and health risks, prompting the search for safer alternatives. Complementary selection markers, such as sugar utilization markers, offer a promising solution. These markers use carbohydrates as carbon sources for growth and are associated with the natural metabolism of lactic acid bacteria and yeast. This review discusses the use of specific sugars, such as lactose, melibiose, sucrose, D-xylose, glucosamine, and N-acetylglucosamine, as selection markers, highlighting their advantages and limitations. In summary, this review underscores the importance of food-grade selection markers in genetic engineering and offers insights into their applications, benefits, and challenges, providing valuable information for researchers in the field of food microbiology and biotechnology.
Measurement of Accident Risk and a Case Study from Hungary
Authors: Ötvös Viktoria , Török Ádám 
Published: March 2024

For the cost-benefit analysis of road safety measures, it is essential to estimate the national value of statistical life. By calculating the updated values, it is possible to assess the aggregate national value of statistical life for road traffic crashes, thereby also characterizing the road safety situation in the country. It is important that the values set and the methods used are compatible with the practices of the European Member States. It must be stressed that updating the values is of major importance both for the cost-benefit analysis of the various road safety measures and for raising public and decision-makers' awareness of the huge losses. The full identification and use of loss figures is an important element of road safety. In this article we present possible methods for estimating the value of statistical life.
Analysis of Constraints against Efficiency of Seaport-hinterland Logistics in Nigeria
Authors: Adepoju Olusegun Onifade 
Published: March 2024

Having realized that most Nigerian seaports are congested and the problem of moving goods have been difficult, the Federal Government through Bureau of Public Enterprises and Nigerian Shippers’ Council were mandated to identify Inland Container Depots (ICDs) and Container Freight Stations (CFSs) across the country with connectivity to rail transport. Since 2004 to date, these have mostly not been functioning. This paper therefore examined the constraints and possible factors responsible. The Nigerian Ports Authority, Road Haulage Association, Terminal Operators, selected Shipping companies were used as respondents. 34.1% (253) from the population of 743 respondents were sampled with the use of Cochran formula and stratified random sampling technique. Shaphiro Test and multiple regression were used to analyze the constraints against the use of ICDs and CFSs. Principal Component Analysis was used to extract the major factors hindering port-hinterland logistics in Nigeria. It was observed that 50% of general logistics constraints emanated from lack of efficient rail system, enforcement and finance combined. Extracted causative factors against port-hinterland movements of goods are: inadequate terminal capacity, parking and inadequacy of cargo handling facilities. The research concluded that both general constraints and causative factors are to be looked into with stringent policy enforcement.
Emesis inducida por administración de ácido tranexámico en gatos
Authors: Vaca Granda Mario David , Villamarin Barragán Darwin Rafael 
Published: March 2024

Introducción: aunque se ha cuestionado la eficacia de utilizar eméticos para la descontaminación en casos de intoxicación en seres humanos, en medicina veterinaria, se ha observado que la exposición a sustancias como productos farmacéuticos, cebollas, chocolates, tabaco, insecticidas, pesticidas, y otros elementos extraños que puedan ser eliminados por vómito sin causar daño, podría beneficiarse significativamente mediante la emesis inducida en un periodo de tiempo adecuado. En el presente estudio, se evaluó la eficacia del ácido tranexámico en la inducción del vómito en gatos seleccionados al azar y en óptimo estado de salud. Se llevaron a cabo una monitorización cuidadosa de los efectos del fármaco con el objetivo de lograr la emesis de manera controlada. Objetivo. El objetivo de la presente investigación fue evaluar la eficacia con dos experimentos: el uno incrementando las dosis con repeticiones de cinco minutos entre dosis y el otro con una sola dosis hasta obtener la emesis. Metodología. Esta investigación tuvo un enfoque cuantitativo experimental de tipo descriptivo donde 10 gatos fueron expuestos a dos experimentos en el primero (T1), se aplicaron tres dosis de 10mg/kg, 20mg/kg y 30mg/kg, con intervalos de 5 minutos para valorar la dosis efectiva. En el segundo experimento (T2), se realizó exposición a una sola dosis con intervalos de una semana para la siguiente dosis y así determinar a qué dosis (única) presenta la emesis. Resultados: El 90% de los gatos tuvo la emesis inducida en un periodo de no más 230 segundos y con un máximo de tres eventos por gato. Conclusión: El ácido tranexámico demostró ser eficaz en inducir el vómito, observándose que la emesis se produjo con el aumento de la dosis del fármaco, alcanzando este efecto incluso con una sola dosis de 40 mg/kg. Área de estudio: Medicina Veterinaria.
Penguatan PKK untuk Menumbuhkembangkan Koperasi Wanita di Desa Lapeo
Authors: Asriani  , Ikhsan Taufik , Nizar  
Published: March 2024

Pemberdayaan ibu-ibu PKK melalui Koperasi wanita selain untuk mesukseskan salah satu program pokok PKK yaitu kehidupan berkoperasi juga dapat memajukan perekonomian desa dan membantu meningkatkan ekonomi keluarga. Tujuan dilaksanakan pengabdian ini untuk memberikan solusi atas permasalahan macetnya koperasi di Desa Lapeo. Pendekatan yang dilakukan melalui sosialisasi dengan memberikan materi terkait dengan jenis-jenis koperasi yang bisa dikembangkan oleh ibu-ibu PKK untuk mengaktifkan kembali koperasi dengan mengkhususkan pada koperasi wanita. Hasil pengabdian menunjukan bahwa melalui sosialisasi yang dilaksankan tim pengabdi, ibu-ibu PKK menjadi paham hal-hal yang mengakibatkan macetnya koperasi di Desa Lapeo. Selain itu ibu-ibu PKK mengetahui jenis-jenis koperasi mana yang cocok untuk dikembangkan sesuai dengan karakteristik ibu-ibu PKK.
Influenza and COVID-19 co-infection and vaccine effectiveness against severe cases: a mathematical modeling study
Authors: Liang Jingyi , Wang Yangqianxi , Lin Zhijie , He Wei , Sun Jiaxi , Li Qianyin , Zhang Mingyi , Chang Zichen , Guo Yinqiu , Zeng Wenting , Liu Tie , Zeng Zhiqi , Yang Zifeng , Hon Chitin 
Published: March 2024

BackgroundInfluenza A virus have a distinctive ability to exacerbate SARS-CoV-2 infection proven by in vitro studies. Furthermore, clinical evidence suggests that co-infection with COVID-19 and influenza not only increases mortality but also prolongs the hospitalization of patients. COVID-19 is in a small-scale recurrent epidemic, increasing the likelihood of co-epidemic with seasonal influenza. The impact of co-infection with influenza virus and SARS-CoV-2 on the population remains unstudied.MethodHere, we developed an age-specific compartmental model to simulate the co-circulation of COVID-19 and influenza and estimate the number of co-infected patients under different scenarios of prevalent virus type and vaccine coverage. To decrease the risk of the population developing severity, we investigated the minimum coverage required for the COVID-19 vaccine in conjunction with the influenza vaccine, particularly during co-epidemic seasons.ResultCompared to the single epidemic, the transmission of the SARS-CoV-2 exhibits a lower trend and a delayed peak when co-epidemic with influenza. Number of co-infection cases is higher when SARS-CoV-2 co-epidemic with Influenza A virus than that with Influenza B virus. The number of co-infected cases increases as SARS-CoV-2 becomes more transmissible. As the proportion of individuals vaccinated with the COVID-19 vaccine and influenza vaccines increases, the peak number of co-infected severe illnesses and the number of severe illness cases decreases and the peak time is delayed, especially for those &gt;60 years old.ConclusionTo minimize the number of severe illnesses arising from co-infection of influenza and COVID-19, in conjunction vaccinations in the population are important, especially priority for the elderly.
Preoperative glucose-to-lymphocyte ratio predicts survival in cancer
Authors: Liu Le , Zhang Bei-bei , Li Yuan-zhou , Huang Wen-juan , Niu Ye , Jia Qing-chun , Wang Wen , Yuan Jia-rui , Miao Shi-di , Wang Rui-tao , Wang Guang-yu 
Published: March 2024

BackgroundSystemic inflammation and glucose metabolism have been closely related to the survival of cancer patients. Therefore, we aimed to evaluate whether preoperative glucose-to-lymphocyte ratio (GLR) can be used to predict the survival of cancer patients.MethodsWe retrospectively examined 2172 cancer patients who underwent surgery from January 1, 2014, to December 31, 2016. There were 240 patients with non-small cell lung cancer (NSCLC), 378 patients with colorectal cancer (CRC), 221 patients with breast cancer (BC), 335 patients with gastric cancer (GC), 270 patients with liver cancer, 233 patients with esophageal cancer (EC), 295 patients with renal cancer, and 200 patients with melanoma. The formula for preoperative GLR calculation was as follows: GLR=glucose/lymphocyte count. The overall survival (OS) was estimated using the Kaplan-Meier method. The predictive factors for OS were determined using multivariate analysis.ResultsThe Kaplan-Meier analysis showed that the median survival time in the high-GLR group was much shorter than that of those in the low-GLR group for different cancers. Cox multivariate regression analysis reveals that preoperative GLR was an independent factor for predicting overall survival in different tumor types.ConclusionElevated preoperative GLR was remarkably associated with a poorer prognosis in patients with NSCLC, CRC, breast cancer, gastric cancer, kidney cancer, liver cancer, esophageal cancer, and melanoma. Preoperative GLR promises to be an essential predictor of survival for cancer patients.
Association between fatigue, peripheral serotonin, and L-carnitine in hypothyroidism and in chronic fatigue syndrome
Authors: Raij Tommi , Raij Kari 
Published: March 2024

BackgroundFatigue of unknown origin is a hallmark symptom in chronic fatigue syndrome (CFS) and is also found in 20% of hypothyroidism patients despite appropriate levothyroxine treatment. Here, we suggest that in these disorders, peripheral serotonin levels are low, and elevating them to normal range with L-carnitine is accompanied with reduced fatigue.MethodsWe conducted a retrospective analysis of follow-up clinical data (CFS N=12; hypothyroidism with fatigue N=40) where serum serotonin and fatigue levels were compared before vs. after 7 weeks of oral L-carnitine supplementation.ResultsAfter L-carnitine, serotonin increased (8-fold in CFS, Sig. = 0.002, 6-fold in hypothyroidism, Sig. &lt; 0.001) whereas fatigue decreased (2-fold in both CFS and hypothyroidism, Sig. = 0.002 for CFS, Sig. &lt; 0.001 for hypothyroidism). There was a negative correlation between serotonin level and fatigue (for CFS, rho = -0.49 before and -0.67 after L-carnitine; for hypothyroidism, rho = -0.24 before and -0.83 after L-carnitine).ConclusionsThese findings suggest a new link between low peripheral serotonin, L-carnitine, and fatigue.
Comparison of the effects of monounsaturated fatty acids and polyunsaturated fatty acids on the lipotoxicity of islets
Authors: Liu Wen , Zhu Min , Liu Jingyi , Su Shan , Zeng Xin , Fu Fudong , Lu Yanrong , Rao Zhiyong , Chen Younan 
Published: March 2024

BackgroundMonounsaturated fatty acids (MUFAs) and polyunsaturated fatty acids (PUFAs) have been reported to combat saturated fatty acid (SFA)-induced cellular damage, however, their clinical effects on patients with metabolic diseases such as diabetes and hyperlipidemia are still controversial. Since comparative studies of the effects of these two types of unsaturated fatty acids (UFAs) are still limited. In this study, we aimed to compare the protective effects of various UFAs on pancreatic islets under the stress of SFA-induced metabolic disorder and lipotoxicity.MethodsRat insulinoma cell line INS-1E were treated with palmitic acid (PA) with or without UFAs including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), arachidonic acid (AA), and oleic acid (OA) to determine cell viability, apoptosis, endoplasmic reticulum (ER) stress, and inflammatory. In vivo, male C57BL/6 mice were fed a 60% high-fat diet (HFD) for 12 w. Then the lard in HFD was partially replaced with fish oil (FO) and olive oil (OO) at low or high proportions of energy (5% or 20%) to observe the ameliorative effects of the UFA supplement.ResultsAll UFAs significantly improved PA-induced cell viability impairment in INS-1E cells, and their alleviation on PA induced apoptosis, ER stress and inflammation were confirmed. Particularly, OA had better effects than EPA, DHA, and AA on attenuating cellular ER stress. In vivo, the diets with a low proportion of UFAs (5% of energy) had limited effects on HFD induced metabolic disorder, except for a slight improved intraperitoneal glucose tolerance in obese mice. However, when fed diets containing a high proportion of UFAs (20% of energy), both the FO and OO groups exhibited substantially improved glucose and lipid metabolism, such as decrease in total cholesterol (TC), low-density lipoprotein (LDL), fasting blood glucose (FBG), and fasting blood insulin (FBI)) and improvement of insulin sensitivity evidenced by intraperitoneal glucose tolerance test (IPGTT) and intraperitoneal insulin tolerance test (IPITT). Unexpectedly, FO resulted in abnormal elevation of the liver function index aspartate aminotransferase (AST) in serum. Pathologically, OO attenuated HFD-induced compensatory hyperplasia of pancreatic islets, while this effect was not obvious in the FO group.ConclusionsBoth MUFAs and PUFAs can effectively protect islet β cells from SFA-induced cellular lipotoxicity. In particular, both OA in vitro and OO in vivo showed superior activities on protecting islets function and enhance insulin sensitivity, suggesting that MUFAs might have greater potential for nutritional intervention on diabetes.
Association between systemic immune-inflammation index and psoriasis: a population-based study
Authors: Zhao Xiya , Li Junqin , Li Xinhua 
Published: March 2024

BackgroundThe systemic immune-inflammation index (SII),as measured by lymphocyte, neutrophil and platelet counts in peripheral blood, is regarded as a favorable indicator of both inflammatory state and immune response. Psoriasis is an immune-mediated disease notable for its chronic inflammation of the entire system. Our research sought to explore the latent link between psoriasis and SII.MethodsWe performed a cross-sectional investigation utilizing data extracted from the National Health and Nutrition Examination Survey (NHANES, 2009-2014). Employing multivariate linear regression models and subgroup analysis, we sought to uncover the association between SII and psoriasis.ResultsThis study enrolled a total of 17,913 participants as part of its research cohort. Our multivariate linear regression analysis revealed a notable and positive correlation between SII and psoriasis [1.013 (1.000, 1.026)]. As SII tertiles increased, the risk of psoriasis demonstrated an upward trend. The significant dependence on this positive association were maintained in women, BMI(≥ 30 kg/m2),non-stroke and non-cancer subjects in subgroup analysis and interaction tests. Furthermore, we identified a significant association between SII and psoriasis, characterized by two consecutive inverted U-shaped patterns. Notably, the analysis revealed the most prominent inflection point at a specific value of 797.067.ConclusionsThe results indicate a significant correlation between elevated SII levels and the presence of psoriasis. However, to corroborate and strengthen these results, additional large-scale prospective studies are required.
In-hospital stroke protocol outcomes before and after the implementation of neurological assessments by telemedicine: an observational case–control study
Authors: Massaud Rodrigo Meirelles , Accorsi Tarso Augusto Duenhas , Massant Cristina Gonçalves , Silva Gisele Sampaio , de Carvalho Leite Anna Verena , Franken Marcelo , Moreira Flavio Tocci , Köhler Karen Francine , De Amicis Lima Karine , Morbeck Renata Albaladejo , Pedrotti Carlos Henrique Sartorato 
Published: March 2024

PurposeStroke is the second leading cause of global adult mortality and the primary cause of disability. A rapid assessment by a neurologist for general and reperfusion treatments in ischemic strokes is linked to decreased mortality and disability. Telestroke assessment is a strategy that allows for neurological consultations with experienced professionals, even in remote emergency contexts. No randomized studies have compared face-to-face neurological care outcomes with telestroke care. Whether neurologists in an institution achieve better results remotely than in person is also unknown. This study aimed to compare mortality and other outcomes commonly measured in stroke protocols for stroke patients assessed by a neurologist via face-to-face evaluations and telestroke assessment.MethodsObservational single-center retrospective study from August/2009 to February/2022, enrolling 2,689 patients with ischemic stroke, subarachnoid hemorrhage, and intracerebral hemorrhage. Group 1 (G1) comprised 2,437 patients with in-person neurological assessments, and Telemedicine Group 2 (G2) included 252 patients.ResultsThe in-person group had higher admission NIHSS scores (G1, 3 (0; 36) vs. G2, 2 (0; 26), p &lt; 0.001). The door-to-groin puncture time was lower in the in-person group than in the telestroke group (G1, 103 (42; 310) vs. G2, 151 (109; 340), p &lt; 0.001). The telestroke group showed superior metrics for door-to-imaging time, symptomatic hemorrhagic transformation rate in ischemic stroke patients treated with intravenous thrombolysis, hospital stay duration, higher rates of intravenous thrombolysis and mechanical thrombectomy, and lower mortality. Symptomatic hemorrhagic transformation rate was smaller in the group evaluated via telestroke (G1, 5.1% vs. G2, 1.1%, p = 0.016). Intravenous thrombolysis and mechanical thrombectomy rates were significantly higher in telestroke group: (G1, 8.6% vs. G2, 18.2%, p &lt; 0.001 and G1, 5.1% vs. G2, 10.4%, p = 0.002, respectively). Mortality was lower in the telestroke group than in the in-person group (G1, 11.1% vs. G2, 6.7%, p = 0.001). The percentage of patients with an mRS score of 0–2 at discharge was similar in both groups when adjusting for NIHSS score and age.ConclusionThe same neurological emergency team may assess stroke patients in-person or by telemedicine, with excellent outcome metrics. This study reaffirms telestroke as a safe tool in acute stroke care.