bluuebunny/crossref_metadata_2025_split huggingface dataset:
Innovative Technologies for Improving the Sustainability of the Food Drying Industry
Authors: Nowacka Małgorzata , Matys Aleksandra , Witrowa-Rajchert Dorota 
Published: April 2024

Abstract
Purpose of Review
Drying as a preservation method for plant materials improves microbial and nutritional quality, however, such processing needs a lot of energy. Thus, different approaches are described as the use of the nonthermal processing (pulsed electric field, ultrasound, high-pressure processing, ethanol application) to reduce drying time and obtain a higher quality of final product.

Recent Findings
There are given several examples for nonthermal processing, which highlight the positive impact on drying time, bioactive compounds content, and energy consumption for different food products. Also, the other aspects are described of the use of conventional drying methods, including hot-air drying, freeze-drying, microwave drying, infrared drying, and vacuum drying, emphasizing their advantages and limitations. Furthermore, the concept of hybrid drying technologies, integrating various methods is described. Additionally, the importance of solar drying is presented as an eco-friendly method, and the growing interest in combined drying methods. Also, a practical example of a mobile drying unit project is presented, showcasing its potential for versatile use in different locations and farms. However, for scaling up the processing, the optimization of the drying process in the laboratory scale into industrial scales is done through methods like Response Surface Methodology (RSM) and others. This paper presents a brief overview of developing drying technologies according to the sustainable approach in the food industry.

Summary
In the aim of sustainability and efficiency in food science, innovative pretreatments coupled with hybrid drying methods, play a crucial role in producing high-quality products with lower energy consumption and reduced investment costs, emphasizing the importance of incorporating renewable energy in new drying solutions.
Optimal pumping policy from well field connected with a stream
Authors: Kerebih Mulu Sewinet , Aynalem Solomon Bogale , Keshari Ashok K. 
Published: April 2024

AbstractConjunctive use management of water resources is of paramount importance in the backdrop of the growing demand for freshwater resources. With this viewpoint, this study is aimed to present a methodological approach utilizing the combined use of simulation and optimization models for evolving strategies or policies for the management of water resources in a well-field connected to a stream. The proposed methodology incorporates the coupling of the groundwater simulation model with the optimization model for decision-making through the response matrix method. In this study, a numerical groundwater flow model using MODFLOW was used to simulate the response of stream-aquifer interactions. A linear optimization model was formulated to account for the best optimal groundwater withdrawal taking into consideration the allowable drawdown, permissible stream flow depletion, and satisfaction of the water demands. Such management options permit the investigation of alternative strategies for groundwater abstraction in a well-field hydraulically connected to a stream for sustainable development of water resources. The model was applied in a hypothetical well field study area hydraulically connected to a stream and satisfactory results were obtained. The methodology was also very important to understand the tradeoff between groundwater withdrawal and the depletion of flow to the nearby stream. This approach was applied to the Aynalem well field stream-aquifer system which is located in Northern Ethiopia. Results show that groundwater extraction from the Aynalem well field triggers stream flow depletion and it is possible to decrease the stream flow depletion by 3.5–4.5% by adjusting current groundwater withdrawal schedules and configuration of existing wells.
Further insights into steady three-dimensional MHD Sakiadis flows of radiating-reacting viscoelastic nanofluids via Wakif’s-Buongiorno and Maxwell’s models
Authors: Wakif Abderrahim , Zaydan Mostafa , Sehaqui Rachid 
Published: April 2024

AbstractKeeping in mind the stress relaxation tendency of many viscoelastic multi-phase flows (e.g., polymer solution flows and transport phenomena of red cell suspensions within blood media), the present research investigation intends principally to develop a realistic model for revealing properly the aspects of reacting-radiating Maxwell nanofluids during their laminar boundary layer flows in the steady regime over a horizontal impermeable surface under a transversal magnetic influence. For this purpose, the principal leading differential formulation is derived theoretically by linking Wakif’s-Buongiorno approach with Maxwell’s model. By invoking fundamentally the general boundary layer assumptions and the passive control strategy for the nanoparticles, the governing PDEs’ formulation is simplified accordingly and then stated properly for the case of the convective heating condition at the impermeable bi-stretching surface. By executing a feasible non-dimensionalization technique, the monitoring ODEs’ system is achieved successfully, whose solutions are presented precisely in different illustrative scenarios using Richardson’s extrapolation method. After carrying out successfully several validating tests, it is demonstrated that the weakly viscoelastic feature has generally a slight delaying effect on the nanofluid motion. This dynamical weakening can be reinforced more with the generation of thermal energy by intensifying the external magnetic field source. Additionally, these physical factors show an intensifying influence on the surface drag forces. However, a dropping impression is seen for the local heat transfer at the contact surface. Contrary to the broadening impact of the radiative heat transfer as well as the convective heating and thermophoresis mechanisms on the thermal and mass boundary layer regions, it is witnessed that the first-order chemical reaction mechanism and Brownian’s motion exhibit a shrinking impact on the mass boundary layer region.
Analysis of the onset, withdrawal, and variability of monsoon rainfall in the face of climate change
Authors: Shariot-Ullah Md. , Akhter Salma , Acharjee Tapos Kumar , Hasan Md. Moudud 
Published: April 2024

AbstractClimate change is affecting the precipitation system in Bangladesh, particularly in the northwestern hydrological zone. This study analyzed the monsoon rainfall variability from 1991 to 2015, revealing a shifting pattern and past trends. This study used the Mann–Kendall test and Sen’s slope (MAKESENS) statistical model to evaluate the annual total rainfall and monsoon rainfall. Approximately 71–78% of the total rainfall occurred during the monsoon season at all stations, with Rangpur being the rainiest and Rajshahi being the driest. The annual rainfall trend decreased, with highly variable arrival and withdrawal days. The monsoon arrived early by 2 to 39 days and late by 1 to 72 days from the reference day. The withdrawal of monsoon rainfall occurred 1 to 38 days early and 1 to 39 days late. These findings can be used to plan and manage agricultural practices at the local level in northwestern Bangladesh.
Magnetospheric‐Ionospheric‐Atmospheric Implications From the Juno Flyby of Ganymede
Authors: Waite J. H. , Greathouse T. K. , Carberry Mogan S. R. , Sulaiman A. H. , Valek P. , Allegrini F. , Ebert R. W. , Gladstone G. R. , Kurth W. S. , Connerney J. E. P. , Clark G. , Bagenal F. , Duling S. , Romanelli N. , Bolton S. , Vorburger A. , Paranicas C. , Kollmann P. , Mauk B. , Hansen C. , Buccino D. , Johnson R. E. , Wilson R. J. , Teolis B. 
Published: April 2024

AbstractJuno flew over the northern mid‐latitudes of Ganymede during orbit 34 of the Juno mission, reaching an altitude of 1,053 km (16:56:07.972 UTC) at a sub spacecraft latitude/longitude of 33.66N, 57.5W degrees on 7 June 2021. Between 16:43 and 17:02 UT, Juno pierced Ganymede's magnetosphere at a velocity relative to Ganymede of 18.57 km s−1. Juno's instrumentation provided a unique opportunity to sample the local environment of Ganymede and its magnetosphere. We present measurements of the composition of the polar ionospheric outflow and the energetic electrons that penetrate Ganymede's atmosphere and produce its aurora. When these new observations are combined with modeling, conclusions can be drawn that affect our understanding of the atmosphere of Ganymede. The measured JADE precipitating plasma electrons provide an energy flux beyond that needed to create the observed oxygen emissions measured by UVS, but the electron energy spectrum is optically thin to the sparse atmosphere and does not provide the observed oxygen ultraviolet emission unless the O2 column density is increased by over an order of magnitude compared to previous atmospheric models. More than 99% of the electron energy flux passes through the atmosphere into the ice, thereby increasing the H2 and O2 content of the atmosphere. The increased H2 and O2 production is largely responsible for increasing the oxygen column density to a level that produces within known uncertainties the OI135.6 and OI130.4 nm emissions when bombarded by the electron energy flux observed by JADE. This suggests that past modeling efforts have underestimated the density of the atmosphere by over an order of magnitude.
Evolution of Impact Basin Gravity Signatures on the Lunar Farside: A Long‐Term Alteration Process
Authors: Lompa T. , Ebbing J. , Wünnemann K. 
Published: April 2024

AbstractLunar impact basins are critical markers to understand the early bombardment history. This study focuses on isostatic compensation processes at 16 lunar farside basins, exploring how long‐term alteration processes affect estimates of impactor sizes and timing. Using a lithospheric flexure model, we analyze the isostatically compensated gravity signature of these basins. Our approach is based on previously published basin formation models using the iSALE‐2D shock physics code. Here we investigate how isostatic compensation processes alter the gravity signature using models of basin formation as initial conditions. We compare our results with the present day observed gravity data. We assume that isostatic compensation is the result of flexural deformation of the crust‐mantle boundary with varying lithospheric elastic thicknesses. Our results indicate that the effect of isostatic compensation on the gravity signature varies depending on the thermal conditions at the time of impact. We find that despite this variability, the overall influence of isostatic compensation on the gravity signature is generally moderate to minor. Additionally, our analysis is consistent with previous studies that have shown that the elastic thickness varies across the Moon. Our findings contribute to our understanding of the relationship between basin formation and the thermal evolution of the Moon. The variations in elastic thickness found provide nuanced insights into lunar geological processes and improve our understanding of the early history of the Moon.
Trade‐Off Between Light Deprivation and Desiccation in Intertidal Seagrasses Due To Periodic Tidal Inundation and Exposure: Insights From a Data‐Calibrated Model
Authors: Wang Xinyan , Adams Matthew P. , Shao Dongdong 
Published: April 2024

AbstractSome seagrass species thrive in shallow intertidal zones globally, adapting to periodic tidal inundation and exposure with distinctive physiological traits and offering crucial ecosystem services. However, predicting the responses of intertidal seagrasses to external stressors is hampered by the complexity of the dynamic and harsh environments they occupy. Intertidal seagrass growth models, especially those incorporating dynamic physiological responses, are scarce in the literature. Our study comprehensively collated relevant data from the literature to parameterize the relationship between air exposure, seagrass leaf water content and photosynthetic efficiency to inform new growth rate functions for generalizable intertidal seagrass growth models. We tested the applicability of these model formulations for scenarios with varying physiological process assumptions, seagrass species, tidal conditions, meadow elevations and water turbidity. We found that neglecting air‐exposed physiological responses (i.e., leaf water content loss and reduced photosynthetic efficiency) can substantially overestimate seagrass growth rates. We also observed a trade‐off between light deprivation and desiccation on intertidal seagrass growth under specific tidal ranges and turbidity conditions. This can yield an “optimal” elevation where overall stress of desiccation (increasing with meadow elevation) and light deprivation (decreasing with meadow elevation) are minimized. The predicted optimal elevation, that is, the most suitable habitat for intertidal seagrass, moves upward as water turbidity increases. Our study provides conceptual and quantitative guidance for ecological modelers to include air exposure responses of intertidal seagrasses in coastal ecosystem models. The model also helps to evaluate the viability of intertidal seagrass habitats and inform decisions on coastal ecosystem management under changing environmental conditions.
The requirement of the mitochondrial protein NDUFS8 for angiogenesis
Authors: Xiong Qian-wei , Jiang Kun , Shen Xiao-wei , Ma Zhou-rui , Yan Xiang-ming , Xia Hao , Cao Xu 
Published: April 2024

AbstractMitochondria are important for the activation of endothelial cells and the process of angiogenesis. NDUFS8 (NADH:ubiquinone oxidoreductase core subunit S8) is a protein that plays a critical role in the function of mitochondrial Complex I. We aimed to investigate the potential involvement of NDUFS8 in angiogenesis. In human umbilical vein endothelial cells (HUVECs) and other endothelial cell types, we employed viral shRNA to silence NDUFS8 or employed the CRISPR/Cas9 method to knockout (KO) it, resulting in impaired mitochondrial functions in the endothelial cells, causing reduction in mitochondrial oxygen consumption and Complex I activity, decreased ATP production, mitochondrial depolarization, increased oxidative stress and reactive oxygen species (ROS) production, and enhanced lipid oxidation. Significantly, NDUFS8 silencing or KO hindered cell proliferation, migration, and capillary tube formation in cultured endothelial cells. In addition, there was a moderate increase in apoptosis within NDUFS8-depleted endothelial cells. Conversely, ectopic overexpression of NDUFS8 demonstrated a pro-angiogenic impact, enhancing cell proliferation, migration, and capillary tube formation in HUVECs and other endothelial cells. NDUFS8 is pivotal for Akt-mTOR cascade activation in endothelial cells. Depleting NDUFS8 inhibited Akt-mTOR activation, reversible with exogenous ATP in HUVECs. Conversely, NDUFS8 overexpression boosted Akt-mTOR activation. Furthermore, the inhibitory effects of NDUFS8 knockdown on cell proliferation, migration, and capillary tube formation were rescued by Akt re-activation via a constitutively-active Akt1. In vivo experiments using an endothelial-specific NDUFS8 shRNA adeno-associated virus (AAV), administered via intravitreous injection, revealed that endothelial knockdown of NDUFS8 inhibited retinal angiogenesis. ATP reduction, oxidative stress, and enhanced lipid oxidation were detected in mouse retinal tissues with endothelial knockdown of NDUFS8. Lastly, we observed an increase in NDUFS8 expression in retinal proliferative membrane tissues obtained from human patients with proliferative diabetic retinopathy. Our findings underscore the essential role of the mitochondrial protein NDUFS8 in regulating endothelial cell activation and angiogenesis.
The crosstalk between exosomes and ferroptosis: a review
Authors: Wu Jiao , Li Zhongyu , Wu Yu , Cui Ning 
Published: April 2024

AbstractExosomes are a subtype of extracellular vesicles composed of bioactive molecules, including nucleic acids, proteins, and lipids. Exosomes are generated by the fusion of intracellular multivesicular bodies (MVBs) with the cell membrane and subsequently released into the extracellular space to participate in intercellular communication and diverse biological processes within target cells. As a crucial mediator, exosomes have been implicated in regulating ferroptosis—an iron-dependent programmed cell death characterized by lipid peroxide accumulation induced by reactive oxygen species. The involvement of exosomes in iron, lipid, and amino acid metabolism contributes to their regulatory role in specific mechanisms underlying how exosomes modulate ferroptosis, which remains incompletely understood, and some related studies are still preliminary. Therefore, targeting the regulation of ferroptosis by exosomes holds promise for future clinical treatment strategies across various diseases. This review aims to provide insights into the pathophysiology and mechanisms governing the interaction between exosomes and ferroptosis and their implications in disease development and treatment to serve as a reference for further research.
Integration of 3D bioprinting and multi-algorithm machine learning identified glioma susceptibilities and microenvironment characteristics
Authors: Tang Min , Jiang Shan , Huang Xiaoming , Ji Chunxia , Gu Yexin , Qi Ying , Xiang Yi , Yao Emmie , Zhang Nancy , Berman Emma , Yu Di , Qu Yunjia , Liu Longwei , Berry David , Yao Yu 
Published: April 2024

AbstractGlioma, with its heterogeneous microenvironments and genetic subtypes, presents substantial challenges for treatment prediction and development. We integrated 3D bioprinting and multi-algorithm machine learning as a novel approach to enhance the assessment and understanding of glioma treatment responses and microenvironment characteristics. The bioprinted patient-derived glioma tissues successfully recapitulated molecular properties and drug responses of native tumors. We then developed GlioML, a machine learning workflow incorporating nine distinct algorithms and a weighted ensemble model that generated robust gene expression-based predictors, each reflecting the diverse action mechanisms of various compounds and drugs. The ensemble model superseded the performance of all individual algorithms across diverse in vitro systems, including sphere cultures, complex 3D bioprinted multicellular models, and 3D patient-derived tissues. By integrating bioprinting, the evaluative scope of the treatment expanded to T cell-related therapy and anti-angiogenesis targeted therapy. We identified promising compounds and drugs for glioma treatment and revealed distinct immunosuppressive or angiogenic myeloid-infiltrated tumor microenvironments. These insights pave the way for enhanced therapeutic development for glioma and potentially for other cancers, highlighting the broad application potential of this integrative and translational approach.
Resistance mechanisms of SARS-CoV-2 3CLpro to the non-covalent inhibitor WU-04
Authors: Zhang Lijing , Xie Xuping , Luo Hannan , Qian Runtong , Yang Yang , Yu Hongtao , Huang Jing , Shi Pei-Yong , Hu Qi 
Published: April 2024

AbstractDrug resistance poses a significant challenge in the development of effective therapies against SARS-CoV-2. Here, we identified two double mutations, M49K/M165V and M49K/S301P, in the 3C-like protease (3CLpro) that confer resistance to a novel non-covalent inhibitor, WU-04, which is currently in phase III clinical trials (NCT06197217). Crystallographic analysis indicates that the M49K mutation destabilizes the WU-04-binding pocket, impacting the binding of WU-04 more significantly than the binding of 3CLpro substrates. The M165V mutation directly interferes with WU-04 binding. The S301P mutation, which is far from the WU-04-binding pocket, indirectly affects WU-04 binding by restricting the rotation of 3CLpro’s C-terminal tail and impeding 3CLpro dimerization. We further explored 3CLpro mutations that confer resistance to two clinically used inhibitors: ensitrelvir and nirmatrelvir, and revealed a trade-off between the catalytic activity, thermostability, and drug resistance of 3CLpro. We found that mutations at the same residue (M49) can have distinct effects on the 3CLpro inhibitors, highlighting the importance of developing multiple antiviral agents with different skeletons for fighting SARS-CoV-2. These findings enhance our understanding of SARS-CoV-2 resistance mechanisms and inform the development of effective therapeutics.
Enabling robust blue circularly polarized organic afterglow through self-confining isolated chiral chromophore
Authors: Zeng Mingjian , Wang Weiguang , Zhang Shuman , Gao Zhisheng , Yan Yingmeng , Liu Yitong , Qi Yulong , Yan Xin , Zhao Wei , Zhang Xin , Guo Ningning , Li Huanhuan , Li Hui , Xie Gaozhan , Tao Ye , Chen Runfeng , Huang Wei 
Published: April 2024

AbstractCreating circularly polarized organic afterglow system with elevated triplet energy levels, suppressed non-radiative transitions, and effective chirality, which are three critical prerequisites for achieving blue circularly polarized afterglow, has posed a formidable challenge. Herein, a straightforward approach is unveiled to attain blue circularly polarized afterglow materials by covalently self-confining isolated chiral chromophore within polymer matrix. The formation of robust hydrogen bonds within the polymer matrix confers a distinctly isolated and stabilized molecular state of chiral chromophores, endowing a blue emission band at 414 nm, lifetime of 3.0 s, and luminescent dissymmetry factor of ~ 10−2. Utilizing the synergistic afterglow and chirality energy transfer, full-color circularly polarized afterglow systems are endowed by doping colorful fluorescent molecules into designed blue polymers, empowering versatile applications. This work paves the way for the streamlined design of blue circularly polarized afterglow materials, expanding the horizons of circularly polarized afterglow materials into various domains.
An Intricate Network Involving the Argonaute ALG-1 Modulates Organismal Resistance to Oxidative Stress
Authors: Vergani-Junior Carlos A. , Moro Raíssa De P. , Pinto Silas , De-Souza Evandro A. , Camara Henrique , Braga Deisi L. , Tonon-da-Silva Guilherme , Knittel Thiago L. , Ruiz Gabriel P. , Ludwig Raissa G. , Massirer Katlin B. , Mair William B. , Mori Marcelo A. 
Published: April 2024

AbstractCellular response to redox imbalance is crucial for organismal health. microRNAs are implicated in stress responses. ALG-1, the C. elegans ortholog of human AGO2, plays an essential role in microRNA processing and function. Here we investigated the mechanisms governing ALG-1 expression in C. elegans and the players controlling lifespan and stress resistance downstream of ALG-1. We show that upregulation of ALG-1 is a shared feature in conditions linked to increased longevity (e.g., germline-deficient glp-1 mutants). ALG-1 knockdown reduces lifespan and oxidative stress resistance, while overexpression enhances survival against pro-oxidant agents but not heat or reductive stress. R02D3.7 represses alg-1 expression, impacting oxidative stress resistance at least in part via ALG-1. microRNAs upregulated in glp-1 mutants (miR-87-3p, miR-230-3p, and miR-235-3p) can target genes in the protein disulfide isomerase pathway and protect against oxidative stress. This study unveils a tightly regulated network involving transcription factors and microRNAs which controls organisms’ ability to withstand oxidative stress.