bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patients' perception of the duration of analgesia provided by intrathecal bupivacaine/morphine after laparoscopic colorectal surgery: a prospective cohort study
Authors: Lokin Joost L. C. , Savelkoul Claudia , van Eekeren Ramon R. J. P. , Koning Mark V. 
Published: April 2024

Abstract
Purpose
The addition of intrathecal morphine to general anesthesia for laparoscopic colorectal surgery is an effective method of providing analgesia. However, the analgesia duration of approximately 24 hours poses the risk of rebound pain on the second postoperative day. Therefore, this study aimed to investigate the patients' perception on postoperative pain management using the International Pain Outcomes questionnaire on both the first and second postoperative day.

Methods
This prospective single-center cohort study was conducted between November 2020 and March 2021 and included forty patients. The primary outcome was a difference in postoperative pain on the first and second postoperative day. Secondary outcomes included opioid consumption, interference of pain with activities, side effects, and patients’ perception and satisfaction with pain treatment.

Results
The intensity of postoperative pain did not increase on the second postoperative day NRS [numeric rating scale] 5 (2–7 [0–10]) vs 5 (3–7 [1–10]), p=0.414), but the percentage of time spent in severe pain increased (20% (10-40 [0-90]) vs 30% (20-50 [0-80]), p=0.010). There was no difference in opioid consumption (6 mg (0–12) [0–42] vs 6 mg (0–12) [0–29], p=0.914). Pruritis (NRS 2 (0–6 [0–10]) vs 0 (0–3 [0–8]), p=0.001) and dizziness (NRS 2 (0–7 [0–10]) vs 0 (0–2 [0–9]), p=0.002) decreased on the second postoperative day. Patients reported high satisfaction during the first two days after surgery (NRS 8 (7–9) [0–10] vs 8 (7–9) [0–10], p=0.395).

Conclusion
Intrathecal morphine is a suitable analgesic modality in laparoscopic colorectal surgery within an enhanced recovery after surgery program, without causing important rebound pain. Pain scores, however, may be further reduced by adding non-opioid analgesics.
Aflatoxins in cattle concentrate feed and potential carry-over of aflatoxin B1 into milk in Dar es Salaam, Tanzania
Authors: Jonathan Sahan Sylivester , Nalumansi Irene , Birungi Grace 
Published: April 2024

AbstractAflatoxin contamination of animal feed threatens livestock production and can harm human health when aflatoxin B1 (AFB1) is carried over as aflatoxin M1 (AFM1) into milk for human consumption; therefore, aflatoxins in cattle concentrate feeds sold in Dar es salaam, Tanzania were determined in this study. Aflatoxins in cattle concentrate feeds were determined using Enzyme-linked Immuno-sorbent Assay (ELISA) and High-Performance Liquid Chromatography with a Fluorescent Detector (HPLC-FLD) and potential carry-over was determined using carry-over equations. Aflatoxins were found in 78% of the concentrate feed samples in the range LOD to 161.32 µg/kg. The mean total aflatoxins (TAFs) was 25.89 ± 3.3 µg/kg, higher than WHO/US-FDA limit of 20 µg/kg in feed although the difference was insignificant (P = 0.81). AFB1 mean was 18.87 ± 2.45 µg/kg and significantly exceeded the WHO/US-FDA limit of 5 µg/kg of AFB1 in dairy feed (P = 3.05 × 10–10). Aflatoxins B2, G1 and G2, were also detected ranging from ND – 75.06 µg/kg. The calculated AFM1 in milk was in the range 0.001 – 0.363 µg/L in low milkers, 0.002–0.666 µg/L in medium milkers and 0.002–0.806 µg/L in high milkers. Carry-over was estimated to range from 1.2 to 1.7%. This study revealed that concentrate feed sold in Dar es salaam was highly contaminated with aflatoxins; noteworthy aflatoxin B1 exceeded the WHO/US-FDA limit implying potential carry-over into milk which could expose milk consumers to aflatoxins, hence livestock feed chain participants need to be sensitized.
Estudio preliminar e identificación de un campamento de náufragos en el contexto de la Guerra del Brasil (1825-1828), Partido de Patagones, Buenos Aires
Authors: Ciarlo Nicolás C. , Castelli Ana , Rodríguez Saumell Joaquín , Landa Carlos G. , Dam Leonardo , Carabias Amor Diego , Brooks Alasdair , Coll Luis V. J. , Torres Rodrigo 
Published: April 2024

Resumen
La navegación, la tecnología naval, la vida a bordo y las actividades llevadas a cabo en barcos de época moderna y contemporánea han sido temas ampliamente estudiados dentro de la arqueología marítima y náutica. Sin embargo, el devenir de los náufragos sobrevivientes de accidentes y las correspondientes evidencias materiales en la costa, no fueron abordados en grado semejante. Las investigaciones muestran un desarrollo dispar, destacando los trabajos realizados en el Pacífico occidental. En Latinoamérica, esta problemática se encuentra aún apenas esbozada. El estudio arqueológico de campamentos de náufragos puede aportar información novedosa para conocer las relaciones humanas, interpersonales e intergrupales, en situaciones de crisis. En este artículo, presentamos los primeros resultados del análisis arqueológico-histórico de la materialidad asociada al sitio Faro Segunda Barranca 4, localizado en el Partido de Patagones, Provincia de Buenos Aires, Argentina. A partir de una discusión de las diferentes líneas de evidencia, identificamos los restos como un campamento de náufragos en el marco de la Guerra del Brasil o Guerra de Cisplatina (1825-1828).
Foreign Workers in Czechoslovakia in 1945–1950
Authors: Dvořák Tomáš 
Published: April 2024

AbstractForeign workers were a common feature in the economy of postwar Czechoslovakia in various periods of the second half of the twentieth century. This article focuses on foreign labor practices during the first economic plans, namely the two-year plan and the first five-year plan between 1947 and 1950. The number of foreign workers at this time didn't exceed twenty thousand persons and their stays in the country were, with only individual exceptions, short. Workers, who found employment in Czechoslovak agriculture and industry in this period, came from different countries including neighboring Poland, Bulgaria, and Romania, but also from Italy. Recruitment of other groups such as workers from Hungary, the Netherlands, or even China is also considered by the article. These foreign laborers worked in Czechoslovakia under various conditions depending on their methods of recruitment and contracting, the duration of their employment, and other important factors. The basic question this article aims to answer is what the role of Gastarbeit was in Czechoslovakia's communist economic policy. It also examines the motivations of countries that sent workers as well as those of the workers themselves. Finally, the article also attempts to analyze the opportunities and limits of these workers’ strategies in the Czechoslovak labor market.
A finite-volume scheme for fractional diffusion on bounded domains
Authors: Bailo Rafael , Carrillo José A. , Fronzoni Stefano , Gómez-Castro David 
Published: April 2024

Abstract
We propose a new fractional Laplacian for bounded domains, expressed as a conservation law and thus particularly suited to finite-volume schemes. Our approach permits the direct prescription of no-flux boundary conditions. We first show the well-posedness theory for the fractional heat equation. We also develop a numerical scheme, which correctly captures the action of the fractional Laplacian and its anomalous diffusion effect. We benchmark numerical solutions for the Lévy–Fokker–Planck equation against known analytical solutions. We conclude by numerically exploring properties of these equations with respect to their stationary states and long-time asymptotics.
New Insights Into Predictors of Antihypertensive	Adherence
Authors: Nikfarjam Mohammad Reza , Mohammadkhani Shahram , Moradi Ali Reza , Davarpasand Tahereh , Pearce Christina Joanne 
Published: April 2024

Abstract: Background: Low adherence to treatment is the most common cause of uncontrolled hypertension. Evidence suggests that illness perceptions and the physician-patient relationship may have a combined effect on treatment adherence. Aims: We investigated the roles of illness perceptions and the physician-patient relationship in medication and lifestyle modification adherence, and explained them using patients’ experiences with essential hypertension.Method: In this mixed methods explanatory sequential study, we used questionnaires to assess illness perceptions, the physician-patient relationship, and adherence to medication and lifestyle modification guidance ( N = 112) in the first quantitative phase. Based on the results of regression analyses, the second qualitative phase was planned. We collected data from three patients through interviews, observations and journals, and conducted within-case and cross-case analyses. Finally, we integrated quantitative and qualitative findings. Results: The physician-patient relationship was an independent predictor of medication adherence (95% confidence interval [CI]: 0.29 to 5.89), whereas both illness perceptions (95% CI: −0.32 to −0.04) and the physician-patient relationship (95% CI: 1.05 to 9.48) were independent predictors of adherence to lifestyle modification guidance. Qualitative themes, reflecting the patient’s experience of the concepts explored in this study, explained the quantitative results. Mixing methods revealed high consistency between quantitative and qualitative findings. Limitations: Limitations are the inability to infer causal associations among variables and indirect measurement of medication adherence. Conclusion: Shared decision-making on antihypertensive medications promotes medication adherence. Specifically, the illness perception, perceived illness controllability, and non-judgemental patients’ acceptance within a satisfying physician-patient relationship empower patients to adhere to lifestyle modification guidance.
Clinicopathological characteristics and eligibility for adjuvant olaparib of germline BRCA1/2 mutation carriers with HER2-negative early breast cancer
Authors: Morganti Stefania , Jin Qingchun , Vincuilla Julie , Buehler Ryan , Ryan Sean , Stokes Samantha , Parker Tonia , Mittendorf Elizabeth A. , King Tari A. , Weiss Anna , Partridge Ann H. , Bychkovsky Brittany L. , Curigliano Giuseppe , Tayob Nabihah , Lin Nancy U. , Garber Judy E. , Tolaney Sara M. , Lynce Filipa 
Published: April 2024

AbstractFollowing the survival benefit demonstrated in the OlympiA trial, one year of adjuvant olaparib is now recommended for all patients with germline BRCA1/2 pathogenic/likely pathogenic variants (PV) and high-risk, HER2-negative early breast cancer after chemotherapy. However, optimal identification of high-risk patients who may derive benefit from this genomically-directed therapy is debated. In this study, we sought to characterize the real-world proportion of gBRCA1/2 PV carriers eligible for adjuvant olaparib according to the OlympiA criteria, and to compare clinicopathologic characteristics and outcomes between eligible and ineligible patients.
Extraction of high quality and high yield RNA from frozen EDTA blood
Authors: Nguyen Long T. , Pollock Carol A. , Saad Sonia 
Published: April 2024

AbstractPeripheral blood RNA profiling, which can reveal systemic changes in gene expression and immune responses to disease onset and progression, is a powerful tool for diagnosis and biomarker discovery. This technique usually requires high quality RNA, which is only obtainable from fresh blood, or frozen blood that has been collected in special RNA-stabilisation systems. The current study aimed to develop a novel protocol to extract high quality RNA from frozen blood that had been collected in the conventional EDTA tubes. We determined that thawing EDTA blood in the presence of cell lysis/RNA stabilisation buffers (Paxgene or Nucleospin) significantly improved RNA quality (RIN) from below 5 to above 7, which to date has not been shown possible. The EDTA-Nucleospin protocol resulted in 5 times higher yield than the EDTA-Paxgene-PreAnalytix method. The average RIN and mRNA expression levels of five different genes including 18 s, ACTB, MCP1, TNFa and TXNIP using this protocol were also indifferent to those from Paxgene blood, suggesting similar RNA quality and blood transcriptome. Moreover, the protocol allows DNA to be extracted simultaneously. In conclusion, we have developed a practical and efficient protocol to extract high quality, high yield RNA from frozen EDTA blood.
Enhanced YOLO v3 for precise detection of apparent damage on bridges amidst complex backgrounds
Authors: Su Huifeng , Kamanda David Bonfils , Han Tao , Guo Cheng , Li Rongzhao , Liu Zhilei , Su Fengzhao , Shang Liuhong 
Published: April 2024

AbstractA bridge disease identification approach based on an enhanced YOLO v3 algorithm is suggested to increase the accuracy of apparent disease detection of concrete bridges under complex backgrounds. First, the YOLO v3 network structure is enhanced to better accommodate the dense distribution and large variation of disease scale characteristics, and the detection layer incorporates the squeeze and excitation (SE) networks attention mechanism module and spatial pyramid pooling module to strengthen the semantic feature extraction ability. Secondly, CIoU with better localization ability is selected as the loss function for training. Finally, the K-means algorithm is used for anchor frame clustering on the bridge surface disease defects dataset. 1363 datasets containing exposed reinforcement, spalling, and water erosion damage of bridges are produced, and network training is done after manual labelling and data improvement in order to test the efficacy of the algorithm described in this paper. According to the trial results, the YOLO v3 model has enhanced more than the original model in terms of precision rate, recall rate, Average Precision (AP), and other indicators. Its overall mean Average Precision (mAP) value has also grown by 5.5%. With the RTX2080Ti graphics card, the detection frame rate increases to 84 Frames Per Second, enabling more precise and real-time bridge illness detection.
Some properties of subclass of multivalent functions associated with a generalized differential operator
Authors: Byeon Haewon , Balamurugan Manivannan , Stalin T. , Govindan Vediyappan , Ahmad Junaid , Emam Walid 
Published: April 2024

AbstractIn this paper, the new subclass $$\mathcal {S}^n_{b,\lambda ,\delta ,p} ({\alpha })$$

S

b
,
λ
,
δ
,
p

n

(
α
)

of a linear differential operator’s $$\mathcal {N}_{\lambda ,\delta ,p}^{n}f(\zeta )$$

N

λ
,
δ
,
p

n

f

(
ζ
)

associated with multivalent analytical function has been introduced. Further, the coefficient inequalities, extreme points for the extremal function, sharpness of the growth and distortion bounds, partial sums, starlikeness, and convexity of the subclass is investigated.
A green approach for metoclopramide quantification in pharmaceutical products: new HPLC and spectrophotometric methods
Authors: Demir İbrahim , Bulduk İbrahim , Darwısh Ibrahim A. , Enginar Hüseyin 
Published: April 2024

AbstractGreen spectrophotometric and HPLC methods have been developed for the quantification of metoclopramide. In the spectrophotometric method, it was determined by direct absorbance measurement at 273 nm wavelength using ultrapure water as solvent. The Extend C18 column was used for the HPLC method. The mobile phase system consisted of a combination of ethanol and formic acid solution (pH 2.0; 30:70 v/v). Isocratic elution was applied and the flow rate was set at 1.0 mL min−1. Metoclopramide was detected at 273 nm. The methods performed were economical, rapid, environmentally friendly, and simple, providing metoclopramide analysis within 5 min. The methods have been successfully applied in pharmaceutical products without matrix interference. The results of the application of the developed methods to pharmaceutical products were statistically compared and no significant difference was observed between the methods. In addition, the greenness assessment of the developed methods was performed using AGREE software. Our developed methods, based on the use of solvents such as ethanol and water, are proposed as a more environmentally and analyst-friendly option for the quantification of metoclopramide in pharmaceutical products than other methods currently in use.
Effects of high-gravity acceleration forces and anti-gravity maneuver on the cardiac function of fighter pilots
Authors: Soh Moon-Seung , Jang Jae-Hyuk , Park Jin-Sun , Shin Joon-Han 
Published: April 2024

AbstractThe fighter pilots exposed to high gravitational (G) acceleration must perform anti-G maneuvers similar to the Valsalva maneuver. However, the effects of high-G acceleration and anti-G maneuvers on cardiac function have rarely been studied. This study aimed to investigate the effects of high-G forces on cardiac function of fighter pilots. Fighter pilots who underwent regular health check-ups and echocardiography were included (n = 29; 100% men, 41 ± 10 years old; mean flight time, 1821 ± 1186 h). Trainees who had not experienced any flights were included in the control group (n = 16; 100% men, 36 ± 17 years old). Echocardiographic data included left ventricular chamber size, systolic and diastolic functions, right ventricular systolic pressure (RVSP), inferior vena cava (IVC) collapsibility, and tricuspid annular plane systolic excursion (TAPSE). No significant differences in left ventricular ejection fraction, RVSP, or IVC collapsibility were observed between two groups. In the multivariate linear regression analysis with total flight time as an independent continuous variable for fighter pilots, TAPSE was positively correlated with total flight time. The experience of fighter pilots who were exposed to high-G acceleration forces and anti-G maneuvers did not cause cardiac structural changes, but the exposure might be associated with right heart function changes.
Dimerized Hofstadter model in two-leg ladder quasi-crystals
Authors: Aghtouman Sara , Hosseini Mir Vahid 
Published: April 2024

AbstractWe theoretically study topological features, band structure, and localization properties of a dimerized two-leg ladder with an oscillating on-site potential. The periodicity of the on-site potential can take either rational or irrational values. We consider two types of dimerized configurations; symmetric and asymmetric models. For rational values of the periodicity as long as inversion symmetry is preserved both symmetric and asymmetric ladders can host topological phases. Additionally, the energy spectrum of the models exhibits a fractal structure known as the Hofstadter butterfly spectrum, dependent on the dimerization of the hopping and the strength of the on-site potential. In the case of irrational values for the periodicity, a metal-insulator phase transition occurs with small values of the critical strength of the on-site potential in the dimerized cases. Our models incorporate the effects of lattice configuration and quasi-periodicity, paving the way for establishing platforms that host both topological and non-topological phase transitions.
Divergence in regulatory mechanisms of GR-RBP genes in different plants under abiotic stress
Authors: Zhang Yingjie , Mo Yujian , Li Junyi , Liu Li , Gao Yanhu , Zhang Yueqin , Huang Yongxiang , Ren Lei , Zhu Hongbo , Jiang Xingyu , Ling Yu 
Published: April 2024

AbstractThe IVa subfamily of glycine-rich proteins (GRPs) comprises a group of glycine-rich RNA binding proteins referred to as GR-RBPa here. Previous studies have demonstrated functions of GR-RBPa proteins in regulating stress response in plants. However, the mechanisms responsible for the differential regulatory functions of GR-RBPa proteins in different plant species have not been fully elucidated. In this study, we identified and comprehensively studied a total of 34 GR-RBPa proteins from five plant species. Our analysis revealed that GR-RBPa proteins were further classified into two branches, with proteins in branch I being relatively more conserved than those in branch II. When subjected to identical stresses, these genes exhibited intensive and differential expression regulation in different plant species, corresponding to the enrichment of cis-acting regulatory elements involving in environmental and internal signaling in these genes. Unexpectedly, all GR-RBPa genes in branch I underwent intensive alternative splicing (AS) regulation, while almost all genes in branch II were only constitutively spliced, despite having more introns. This study highlights the complex and divergent regulations of a group of conserved RNA binding proteins in different plants when exposed to identical stress conditions. These species-specific regulations may have implications for stress responses and adaptations in different plant species.
Safety and efficacy of the novel Alpha stent for the treatment of intracranial wide-necked aneurysm
Authors: Kim Junhyung , Kim Jung-Jae , Kim Seung Won , Choi Jinyoung , Kim Hanki , Kim Jinwoo , Chung Joonho 
Published: April 2024

AbstractThe Alpha stent is an intracranial closed-cell stent with a unique mesh design to enhance wall apposition. It recently underwent structural modifications to facilitate easier stent deployment. This study aimed to evaluate the safety and efficacy of stent-assisted coil embolization for unruptured intracranial aneurysms using the Alpha stent. Between January 2021 and November 2021, 35 adult patients with 35 unruptured intracranial aneurysms in the distal internal carotid artery were prospectively enrolled. For efficacy outcomes, magnetic resonance angiography at the 6-month follow-up was evaluated using the Raymond-Roy occlusion classification (RROC). The safety outcome evaluated the occurrence of symptomatic procedure-related neurological complications up to 6 months postoperatively. Technical success was achieved in 34/35 (97.1%). Six months postoperatively, aneurysm occlusion showed RROC I in 32/35 (91.4%) and RROC II in 3/35 (8.6%) patients. Procedure-related neurologic complications occurred in one patient (2.9%) who experienced hemiparesis due to acute lacunar infarction, which resulted in a 6-month mRS score of 1. The Alpha stent demonstrated excellent efficacy and safety outcomes in stent-assisted coil embolization of unruptured distal ICA aneurysms. The recent structural modifications allowed for easier stent delivery and deployment.Clinical trial registration number: KCT0005841; registration date: 28/01/2021.