bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of prehabilitation concurrent exercise on functional capacity in colorectal cancer patients: a systematic review and meta-analysis
Authors: Maroto-Izquierdo Sergio , Bautista Iker J. , Menéndez Héctor , Pinto-Fraga Jose , Simò Vicente , Aldecoa César 
Published: March 2024

Abstract

Purpose: Preoperative fitness level is associated with surgical complications and long-term function after major surgery in colorectal cancer (CRC) patients. Exercise-based prehabilitation may represents a feasible strategy to improve preoperative functional and cardiometabolic outcomes. This meta-analysis aimed to examine the efficacy of concurrent exercise (i.e., aerobic and strength exercise) during prehabilitation programs on functional capacity assessed through the 6-minute walking test (6MWT) in comparison with standard cancer care strategies in CRC patients scheduled for surgery.
Methods: A systematic review and meta-analysis of randomized controlled trials was performed. A search of electronic databases [PubMed, Web of Science and EBSCO Host] was conducted to identify all publications employing concurrent exercise in CRC patients up to April 5, 2023. 6 studies met the inclusion criteria. Random-effects meta-analysis were used to calculate the standardized change of mean difference (SCMD) and 95% CI between exercise intervention and control groups for 6MWT distance covered before and after prehabilitation.
Results: Concurrent training during prehabilitation led to significant positive effects on 6MWT (0.28 SCMD [0.03 to 0.54], p=0.037). Sub-group analyses showed higher SCMD (0.48 [0.00 to 0.98]) in younger (i.e., <70 years) CRC patients compared to CRC older patients (0.10 [0.08 to 0.11]). Meta-regression models between SCMD of 6MWT and body mass index, prehabilitation program duration, and baseline 6MWT distance covered did not show any significant relationship. Only age variable shared 54% of variance with SCMD of 6MWT, but without statistical significance (p = 0.076).
Conclusions: This meta-analysis provides evidence supporting the superiority of prehabilitation programs that implement concurrent exercise compared with standard cancer care strategies to promote functional changes, which are well-related with cardiometabolic status and lower post-operation risk in CRC patients.
Non-Invasive Three-Dimensional Breast Tumor Positioning Before Neoadjuvant Systemic Therapy as Promissing Alternative to the Invasive Tumor Marking – Technique Description and Feasibility
Authors: Bjelica Dragana , Colakovic Natasa , Opric Svetlana , Zdravkovic Darko , Loboda Barbara , Petricevic Simona , Gojgic Milan , Zecic Ognjen , Skuric Zlatko , Zecic Katarina , Ivanovic Nebojša 
Published: March 2024

Abstract
Background: Surgical excision of the lodge of the tumor that has completely clinically regressed after neoadjuvant systemic therapy (NAST) is a necessary part of the treatment of early breast cancer. However, it is significantly hampered by the lack of a spatial landmark concerning the location of the pre-existing tumor in the breast. Standard surgical techniques of targeted excision of the pre-existing tumor bed generally rely on invasive insertion of various markers into or around the tumor before starting NAST. Invasive marking techniques are burdened by the disadvantages of technical complexity, invasiveness of procedures, and insufficient precision.
Methods: In this paper authors present an original technique of non-invasive determining of the tumor position in the breast in three dimensions before starting NAST, with intention to overcome the disadvantages of invasive tumor marking. Tumor positioning is performed by ultrasound measurements – detailed description of the technique is given in the main text. The feasibility and precision of the technique was tested by the histological parameters of the adequacy and rationality of excision of the tumor bed, after complete clinical regression of the tumor after NAST, on a pilot series of patients.
Results: A pilot series of 33 patients underwent a non-invasive breast tumor positioning technique before starting NAST. Twelve patients with complete clinical regression after NAST have been operated using a non-invasive tumor positioning technique, so far. In all cases, histological signs of tumor regression were verified in the specimen of the excised tumor bed. The ratio of the resected specimen volume to the volume of the tumor before NAST was on average 0,91, which is in favor of the rationality of excision and a good aesthetic effect.
Conclusion: The initial results of a pilot series of treated patients imply that a non-invasive three-dimensional tumor positioning technique is feasible, with a satisfactory level of oncological safety and aesthetic effects of surgery. Performing a randomised clinical trial comparing this technique with standard techniques of invasive tumor marking is justified.
Potential of TiO2 as a Capping Layer for Industrial c-Si PERC Solar Cells
Authors: Siddiqui Aamenah , Usman Muhammad , Hallén Anders 
Published: March 2024

Abstract

Titanium dioxide (TiO2) has gained popularity specially in photovoltaic applications, owing to its transparency in the visible region, and scratch resistance. In this work, the potential of TiO2 as a capping layer for c-Si p-type SiNx passivated emitter and rear contact (PERC) solar cells is studied through extensive optical and device simulations. The bifacial PERC solar cell model used in this study is calibrated with an experimental device having an efficiency of 22.19%. Device simulation results show that TiO2 deposited by the mesoporous technique outperforms atmospheric pressure chemical vapor deposition (APCVD) and atomic layer deposition (ALD) based TiO2 layers when capped over SiNx (n = 2.1) passivated solar cells. Furthermore, it is shown that the efficiency of SiNx(n = 2.1)/TiO2 based solar cells is maintained, even when the TiO2 layer thickness varies from 75 to 95 nm. To enhance the efficiency further, the type of SiNx layer (characterized by the n value), and the thicknesses of SiNx and TiO2 layers are optimized simultaneously to find the best combination of these parameters. The best front side solar cell efficiency of 22.43%, is obtained when a stack of SiNx(n = 1.99)/TiO2 (t = 58/76 nm) is used. Similarly, a rear side efficiency of 16.59% is achieved when the rear side Al2O3/SiNx stack is capped with mesoporous TiO2. These efficiencies are 0.24 and 1.25% higher, respectively, when compared to the original SiNx passivated PERC solar cell, demonstrating the prospective of using TiO2 in commercial photovoltaic applications.
Enhanced Security Hash Function Leveraging Chaotic Coupling Coefficient in Cross-Coupled Map Lattice
Authors: Li Yuxuan 
Published: March 2024

Abstract
The recent surge in interest within the scientific community towards spatiotemporal chaos underscores its potential for bolstering secure communications and cryptographic mechanisms. This research presents a cutting-edge methodology to amplify the spatiotemporal chaos exhibited by conventional cross-coupled image lattices through the adoption of chaotic coupling coefficients. By innovatively adjusting the structure of these lattices to incorporate chaotic coupling coefficients, we markedly enhance their chaotic dynamics across temporal and spatial dimensions. This advancement facilitates the creation of a secure hash function characterized by substantial security enhancements. Rigorous experimental validation attests to the security, highlighting the chaotic coupling coefficients' pivotal role in augmenting the hash function's defenses against various attacks. This investigation not only introduces a revolutionary alteration to the framework of cross-coupled image lattices but also unveils a pragmatic secure hash function application, demonstrating the significant potential of chaotic systems in the sphere of cryptography. Our findings suggest that integrating chaotic coupling coefficients into cross-coupled image lattices represents a fertile ground for crafting sophisticated cryptographic instruments, thereby paving new pathways in the realm of secure digital communications.
Biosynthetic potential analysis of an Arctic marine-derived strain Aspergillus sydowii MNP-2
Authors: Fu Zhiyang , Gong Xiangzhou , Hu Zhe , Wei Bin , Zhang Huawei 
Published: March 2024

Abstract
Genome mining strategy plays a key role in the discovery of bioactive secondary metabolites (SMs) from microorganisms. This work highlighted deciphering the biosynthetic potential of an Arctic marine-derived strain Aspergillus sydowii MNP-2 by a combination of whole genome analysis and antiSMASH as well as feature-based molecular networking (MN) in the Global Natural Products Social Molecular Networking (GNPS). A completed genomic assembly of 34.9 Mb containing 10 contigs with an N50 scaffold size of 4.1 Mb was generated and a total of 13,218 protein-coding genes and 46 rRNA, 7 sRNA, 32 snRNA and 119 rRNA were annotated using Nr, GO, COG, Pfam, KEGG and other databases. AntiSMASH results indicated that strain MNP-2 harbors 52 biosynthetic gene clusters (BGCs), suggesting a great potential for producing SMs with various structure motifs. Noticeably, these BGC-encoded SMs with therapeutic potential were detected in its metabolic products through GNPS and MN analyses.
Causal Relationship Between Plasma Lipidome and Six Types of Cancer: A Mendelian Randomization Study
Authors: Tang Jincheng , Zhang Jingting , Yang Renyi , Chen Hongyao , Zeng Puhua 
Published: March 2024

Abstract
Background: The plasma lipidome is intricately associated with cancer. However, the causal relationship between them remains uncertain. Therefore, this study employs Mendelian randomization (MR) based on genetic principles to investigate the potential causal relationship between plasma lipidome and six common types of cancer.
Methods: MR analysis utilizes publicly available genetic data, employing a genome-wide association study (GWAS) of 179 lipid species as exposure and GWAS datasets of six different cancers as outcomes. The inverse variance weighted (IVW) method serves as the primary approach, with MR-Egger regression and weighted median (WM) method employed as supplementary methods for analysis. Additionally, sensitivity analyses including Cochran's Q test, MR-Egger intercept test, and leave-one-out analysis are conducted to assess the reliability and stability of causal relationships. The Steiger test is also utilized to determine the directionality of causal relationships.
Results: The IVW analysis reveals that phosphatidylethanolamine (16:0_20:4) levels and others are implicated as risk factors for hepatic cancer, while sphingomyelin (d40:1) levels and others are identified as protective factors against hepatic cancer. Sterol ester (27:1/20:4) levels and others are associated with increased risk of lung cancer, whereas sterol ester (27:1/18:2) levels and others are associated with decreased risk of lung cancer. Sterol ester (27:1/20:3) levels and others are identified as risk factors for colorectal cancer, whereas phosphatidylcholine (18:2_0:0) levels and others are protective against colorectal cancer. Phosphatidylcholine (16:0_20:4) levels and others are linked to increased risk of esophageal cancer, while phosphatidylcholine (16:0_18:3) levels and others are associated with protection against esophageal cancer. Phosphatidylinositol (18:0_20:4) levels and others are identified as risk factors for thyroid cancer, whereas phosphatidylinositol (16:0_18:2) levels and others are protective against thyroid cancer. Diacylglycerol (18:1_18:2) levels and others are identified as protective factors against breast cancer.
Conclusions: There exists a clear causal relationship between plasma lipidome and six types of cancer. Additionally, it has been observed that the same single-nucleotide polymorphisms (SNPs) serve as instrumental variables (IVs), influencing cancer through the plasma lipidome. This provides further avenues and methodologies for early screening and effective treatment of cancer.
Integrin-linked kinase-frizzled 7 interaction maintains cancer stem cells to drive platinum resistance in ovarian cancer
Authors: Atwani Rula , Rogers Amber , Nagare Rohit , Prasad Mayuri , Lazar Virginie , Sandusky George , Pin Fabrizio , Condello Salvatore 
Published: March 2024

Abstract

Background
Platinum-based chemotherapy regimens are a mainstay in the management of ovarian cancer (OC), but emergence of chemoresistance poses a significant clinical challenge. The persistence of ovarian cancer stem cells (OCSCs) at the end of primary treatment contributes to disease recurrence. Here, we hypothesized that the extracellular matrix protects CSCs during chemotherapy and supports their tumorigenic functions by activating integrin-linked kinase (ILK), a key enzyme in drug resistance.
Methods
TCGA datasets and OC models were investigated using an integrated proteomic and gene expression analysis and examined ILK for correlations with chemoresistance pathways and clinical outcomes. Canonical Wnt pathway components, pro-survival signaling, and stemness were examined using OC models. To investigate the role of ILK in the OCSC-phenotype, a novel pharmacological inhibitor of ILK in combination with carboplatin was utilized in vitro and in vivo OC models.
Results
In response to increased fibronectin (FN) secretion and integrin β1 clustering, aberrant ILK activation supported the OCSC phenotype, contributing to OC spheroid proliferation and reduced response to platinum treatment. Complexes formed by ILK with the Wnt receptor frizzled 7 (Fzd7) were detected in tumors and showed a strong correlation with metastatic progression. Moreover, TCGA datasets confirmed that combined expression of ILK and Fzd7 in high grade serous ovarian tumors is correlated with reduced response to chemotherapy and poor patient outcomes. Mechanistically, interaction of ILK with Fzd7 increased the response to Wnt ligands, thereby amplifying the stemness-associated Wnt/β-catenin signaling. Notably, preclinical studies showed that the novel ILK inhibitor compound 22 (cpd-22) alone disrupted ILK interaction with Fzd7 and CSC proliferation as spheroids. Furthermore, when combined with carboplatin, this disruption led to sustained AKT inhibition, apoptotic damage in OCSCs and reduced tumorigenicity in mice.
Conclusions
This “outside-in” signaling mechanism is potentially actionable, and combined targeting of ILK-Fzd7 may represent a new therapeutic strategy to eradicate OCSCs and improve patient outcomes.
PENGUNGKAPAN DIRI ANTARA REMAJA JAWA DAN MADURA
Authors: Nabilah Masturah Alifah 
Published: March 2024

Kebudayaan yang merupakan produk dari budaya memiliki pengaruh dalam pengungkapan diri seseorang. Tiap-tiap masyarakat dengan corak budaya masing-masing memberikan aturan tertentu atas individu pantas atau tidak pantas mengungkapkan diri. Suku Jawa dan Madura memiliki nilai-nilai budaya yang digunakan sebagai pedoman menjalani kehidupan sehari-hari. Tujuan penelitian ini adalah mengetahui perbedaan pengungkapan diri antara remaja Jawa dan Madura. Penelitian ini merupakan penelitian kuantitatif. Sampel adalah mahasiswa yang berusia antara 17-22 tahun berjumlah 50 orang suku Jawa dan 50 orang suku Madura. Pengambilan sampel dengan tehnik accidental sampling (non probability sampling). Metode pengumpulan data yang digunakan adalah skala Thurstone, yaitu skala pengungkapan diri. Adapun metode analisa data yang digunakan adalah t-test. Hasil penelitiaan menunjukkan terdapat perbedaan yang signifikan (t= -10.966; p= 0.000) pengungkapan diri antara remaja Jawa dan Madura. Remaja Madura memiliki tingkat pengungkapan diri yang lebih tinggi (3.1394) dibandingkan dengan remaja Jawa (2.7466). Kata kunci: Pengungkapan diri, Remaja Jawa dan Madura. Culture is a product have an influence in the disclosure of a person. Each community with cultural patterns each providing specific rules for individual worth or not worth expressing themselves. The Javanese and Madura who have cultural values ​​that are used as a guide through daily life. The purpose of this study was to determine the differences between adolescent self-disclosure of Java and Madura. The study is a quantitative research. Sample of this study were students Muhammadiyah University of Malang, aged between 17-22 account 50 Javanese and Madura people. Accidental sampling using sampling techniques (non-probability sampling). Data collection methods used are the Thurstone scale, the scale of self-disclosure. The data analysis method used is the t-test. Based on theoretical studies and research conducted by the researchers that the hypothesis which states there is a difference between adolescent self-disclosure of Java and Madura received. From the results of the study, data showed that there are significant differences (t = -10 966, p = 0.000) between adolescent self-disclosure of Java and Madura.Madura adolescents have high levels of self-disclosure is higher (3.1394) compared with adolescents Java (2.7466). Keyword : Self disclosure, Adolescence Java and Madura
TINGKAT KECEMASAN PADA SANTRI PONDOK PESANTREN
Authors: Novalia Siregar Chynthia 
Published: March 2024

Kecemasan merupakan salah satu kekhawatiran terbesar yang dialami oleh semua individu. Kecemasan ini menghasilkan hal negatif di berbagai aspek kehidupan, khususnya pada aspek akademis. Penelitian ini merupakan penelitian non-eksperimen deskriptif kuantitatif bertujuan untuk mengetahui tingkat kecemasan pada santri Pondok Pesantren. Sampel penelitian ini sebanyak 78 orang santri Pondok Pesantren Nurul Huda Singosari Malang dengan menggunakan Taylor Manifest Anxiety Scale (TMAS) yang terdiri dari 50 item. Analisis penelitian menggunakan Z-Score. Berdasarkan analisis ditemukan bahwa sebesar 14,1% atau 11 santri mengalami kecemasan dengan tingkat tinggi. Sementara yang mengalami tingkat kecemasan sedang sebesar 66,7% atau 52 santri dan sisanya sebesar 19,2% atau 15 santri mengalami tingkat kecemasan rendah. Kata kunci: Kecemasan, Santri pondok pesantren Anxiety is one of the biggest worries experienced by all people. Anxiety produces negative in many aspects of life, especially in the academic aspect. This research is a quantitative non-experimental descriptive aims to determine the level of anxiety on the male boarding school. The sample as many as 78 people Nurul Huda Islamic boarding school students Singosari Malang using the Taylor Manifest Anxiety Scale (TMAS) consisting of 50 item. Analysis of studies using the Z-Score. Based on the analysis it was found that 14.1% or 11 students with a high level of anxiety. While experiencing the anxiety level was at 66.7% or 52 students, and the remaining 19.2% or 15 students experienced low levels of anxiety. Keywords: Anxiety, Boarding school student
Sentralisere eller desentralisere – om inkludering og ekskludering ved kulturskolen som lokalt ressurssenter
Authors: Jordhus-Lier Anne 
Published: March 2024

The article examines different ways of understanding the Norwegian municipal school of music and performing arts as a local resource centre for arts and culture. A central question is whether children are excluded or included when the school’s activities are centralised into one building or, conversely, decentralised and thereby reliant on teachers travelling to teach. These issues help determine whether the school could be an including force in the community. The school’s vision of ‘being for everyone’, which is stated in various policy documents, is a premise for this discussion.
The article builds on a discourse analysis of interviews with teachers in schools of music and arts, as well as document analysis. The findings show that within the school of music and arts field, there are several discourses trying to articulate what the school ought to be, where discourses of decentralisation and centralisation both work to define the school as a local resource centre.
“Novel food”, insetti nel piatto
Authors: Bordenca Ilaria Ventura 
Published: March 2024

Come si produce il cambiamento in campo alimentare ? quali processi semiotici lo caratterizzano ? e che succede nel caso in cui la trasformazione riguarda una proposta dietetica totalmente inusuale nel contesto della cultura occidentale come gli insetti edibili ? questo contributo si concentra sul caso degli insetti a tavola nella cultura gastronomica italiana, attraverso l’analisi di alcuni casi studio della comunicazione mediatica e di brand dello scenario italiano. Emergeranno questioni teoriche che riguardano i processi di significazione del gusto e la costruzione semiotica della collettività.
Être ou ne pas être une marque Analyse sémiotique de la fortune de Coca-Cola Zero
Authors: Perusset Alain 
Published: March 2024

Lancé en 2005, Coca-Cola Zero est rapidement devenu un produit emblématique aux quatre coins du globe. Cependant, au cours des années qui ont suivi sa commercialisation, Coca-Cola Zero a subi des transformations majeures qui, presque 20 ans plus tard, interrogent : le Coca-Cola sans sucres du début des années 2020 est-il toujours le Coca-Cola Zero d’antan ? C’est donc la thématique des identités et stratégies de marques que ce travail aborde. Il s’inscrit dans le sillage des travaux de sémiotique post-greimassienne sur la marque, avec un arrière-plan ricœurien relatif à la question de l’ipséité : une identité reste-t-elle la même à mesure qu’elle évolue ? Un large corpus est retenu pour analyser cette évolution, majoritairement composé des canettes produites au fil des ans, ainsi que de leurs déclinaisons actuelles. Enfin, une définition renouvelée du concept de marque est proposée, qui ouvre des perspectives plus générales pour, 1°, penser le statut des offres commerciales au sein des stratégies de marques de David A. Aaker, et, 2°, produire une grammaire des rôles qu’assume l’interactant dans chacun des régim de sens d’Eric Landowski.
Felicidade, consumismo e mal-estar na civilização
Authors: De Oliveira Mariana Gabriela , Rodrigues Lyvia Renata 
Published: March 2024

O presente estudo tem como objetivo, a partir da perspectiva psicanalítica, analisar como o curta Happiness, de Steve Cutts, auxilia a compreender quais são os sinais do mal-estar da civilização presentes em uma sociedade de consumo que busca pela felicidade que, aparentemente, está por todo lado, mas que ninguém consegue alcançar. A temática felicidade é abordada por Freud no texto Mal-estar na Civilização de 1930, no qual aponta que os homens desejam alcançar a felicidade e permanecer nela, no entanto, para cada sujeito, a resposta sobre onde encontrar felicidade é muito particular, podendo ser por diversos caminhos, mas nenhum garante segurança total. Para ele, a felicidade constante e absoluta não existe, ela acontece de maneira intermitente. A cultura do consumo potencializa a ideia de que através da satisfação dos desejos individuais será possível encontrar felicidade e assim, aguça nos consumidores novos desejos a serem satisfeitos, fazendo-os querer consumir sempre mais. No entanto, o vazio existencial inerente ao ser humano e suas relações não se preenche facilmente com objetos, prazer ou medicação. Todas essas questões levantadas por Freud podem ser analisadas por meio do curta Happiness, que também denuncia os excessos da sociedade moderna, a robotização da vida cotidiana e as estratégias dos indivíduos para lidar com as angústias da vida real, auxiliando na reflexão do consumismo e da busca pela felicidade.