bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Fe Doping Profile on Current Collapse in GaN‐based RF HEMTs
Authors: Xu Linling , Guo Hui , Tao Jiaqi , Zavabeti Ali , Zhou Yugang , Zheng Youdou , Zhang Rong , Chen Dunjun 
Published: March 2024

AbstractUsing computer‐aided design (TCAD) simulation, the impact of the Fe doping profile, including concentration, decay rate, and depth of the doping region on current‐collapse magnitude (▵CC) in 0.5‐μm gated GaN‐based high electron mobility transistors (HEMTs) is systematically investigated. Accurate simulation models are established and developed to facilitate the fabrication of electronics. It is elucidated that the intricate interplay between trapping and de‐trapping of Fe‐related traps at the gate‐drain edge is responsible for current collapse. The concentration and decay rate of the doping region have a more significant impact on current collapse than the depth. Increased trap state density near two‐dimensional electron gas (2DEG) channel caused by deep‐level acceptors would boost ▵CC. However, a minor dynamic reduction in 2DEG density (nT) induces a relatively small ▵CC. By adjusting the concentration, decay rate, and depth of the doping region, ▵CC of GaN‐based Radio Frequency (RF) HEMTs can be reduced by approximately 50.3 %. The optimized distribution of Fe doping discussed in this work helps to prepare GaN‐based RF HEMTs with a limited current collapse effect.
Phosphorescent Platinum(II) Complexes with a Spiro‐fused Xanthene Unit: Synthesis and Photophysical Properties
Authors: Riesebeck Tim , Strassner Thomas 
Published: March 2024

AbstractNovel platinum(II) complexes, derived from the spiro[fluorene‐9,9’‐xanthene] (SFX) motif, were synthesized and combined with different auxiliary ligands such as acetylacetonate (acac), bis(2,4,6‐trimethylphenyl)propane‐1,3‐dionate (mesacac) and dihydrobis(3,5‐dimethylpyrazole‐1‐yl) borate. The final products were obtained in yields of up to 36 % and characterized by NMR, X‐ray and combustion analysis. These complexes have structured green‐blue emission spectra with Commission Internationale de l’Éclairage (CIExy) coordinates of (0.21;0.46). Excellent photoluminescence quantum yields (PLQYs) ranging from 87 %–91 % were found. The emission lifetimes vary from 33 μs to 43 μs. Calculations on the B3LYP/6‐311++G** level of theory reveal, that the nature of the emissive state is dependent on the positional regioisomerism of the SFX motif. The 2‐SFX complexes demonstrate ligand‐centered (3LC) emission, while the 2’‐SFX regioisomer with the mesacac ligand shows a strong 3MLCT character.
Quest for Double Möbius Aromaticity
Authors: Sarmah Kangkan , Guha Ankur K. 
Published: March 2024

AbstractNeutral four‐membered rings with 4n electrons are generally Hückel antiaromatic. On the other hand, 4n electron system can also be Möbius aromatic, although identification has escaped so far. A recent study of double Möbius aromaticity has been put forwarded in the D2h symmetric singlet ground state of four member Pa2B2 ring. Although interesting, but the synthesis possesses a significant challenge as Pa is rare, highly radioactive and toxic. Herein, a synthetically viable four membered Rh2B2 cluster is proposed which contains double Möbius aromaticity. Interestingly, the three membered RhB2− cluster also possess Möbius aromaticity and is the smallest ring to show such phenomenon.
A Healable Quasi‐Solid Polymer Electrolyte with Balanced Toughness and Ionic Conductivity
Authors: Ding Li , Tan Yu , Li Guiliang , Zhang Kaiqiang , Wang Xu 
Published: March 2024

AbstractSolid polymer electrolytes (SPEs) have garnered extensive attention as potential alternatives to traditional liquid electrolytes, primarily due to their prowess in curbing lithium dendrite formation and preventing electrolyte leaks. The quest for SPEs that are both mechanically robust and exhibit superior ionic conductivity has been vigorous. However, achieving a harmonious balance between these two attributes remains a significant challenge. In this study, we introduce a novel quasi‐solid electrolyte, ingeniously crafted from a poly(urethane‐urea) network, enriched with lithium salts and plasticizers. This innovative composition not only boasts remarkable toughness but also ensures commendable ionic conductivity. Our post‐gelation method yields gel polymer electrolytes that undergo rigorous evaluation, leading to an optimized version that stands out with its exceptional room‐temperature ionic conductivity (2.94×10−4 S cm−1) and outstanding toughness (11.9 MJ m−3). Moreover, it demonstrates a broad electrochemical window (4.73 V), remarkable stability across a 600‐hour cycle test, a high capacity retention exceeding 80 % after 100 cycles at 0.2 C, and a noteworthy self‐healing capability. This quasi‐solid polymer electrolyte emerges as a promising contender to replace current liquid electrolyte solutions.
Separation of Biobased Carboxylic Acids by Aqueous Phase Nanofiltration
Authors: Rübenach Lukas , Kruse Niklas , Rose Marcus 
Published: March 2024

AbstractNanofiltration is an energy efficient separation technology with yet not fully explored potential for in situ product recovery from fermentation solutions. In this work, a commercially available cellulose acetate nanofiltration membrane was investigated to separate different carboxylic acids from glucose in an aqueous solution. The membrane showed a high stability and good separation performance at low pH. Dead‐end and cross‐flow experiments revealed the transferability to real fermentation mixtures and demonstrate the possibility of coupling fermentation with in situ product separation.
Evolution of air‐borne vocalization: Insights from neural studies in the archeobatrachian species Bombina orientalis
Authors: Huggenberger Stefan , Walkowiak Wolfgang 
Published: March 2024

AbstractVocalization of tetrapods evolved as an air‐driven mechanism. Thus, it is conceivable that the underlaying neural network might have evolved from more ancient respiratory circuits and be made up of homologous components that generate breathing rhythms across vertebrates. In this context, the extant species of stem anurans provide an opportunity to analyze the connection of the neural circuits of lung ventilation and vocalization. Here, we analyzed the fictive lung ventilation and vocalization behavior of isolated brains of the Chinese fire‐bellied toad Bombina orientalis during their mating season by nerve root recordings. We discovered significant differences in durations of activation of male brains after stimulation of the statoacoustic nerve or vocalization‐relevant forebrain structures in comparison to female brains. The increased durations of motor nerve activities in male brains can be interpreted as fictive calling, as male's advertisement calls in vivo had the same general pattern compared to lung ventilation, but longer duration periods. Female brains react to the corresponding stimulations with the same shorter activity pattern that occurred spontaneously in both female and male brains and thus can be interpreted as fictive lung ventilations. These results support the hypothesis that vocal circuits evolved from ancient respiration networks in the anuran caudal hindbrain. Moreover, we could show that the terrestrial stem archeobatrachian Bombina spec. is an appropriate model to study the function and evolution of the shared network of lung ventilation and vocal generation.
Genomic signatures of climate adaptation in bank voles
Authors: Folkertsma Remco , Charbonnel Nathalie , Henttonen Heikki , Heroldová Marta , Huitu Otso , Kotlík Petr , Manzo Emiliano , Paijmans Johanna L. A. , Plantard Olivier , Sándor Attila D. , Hofreiter Michael , Eccard Jana A. 
Published: March 2024

AbstractEvidence for divergent selection and adaptive variation across the landscape can provide insight into a species' ability to adapt to different environments. However, despite recent advances in genomics, it remains difficult to detect the footprints of climate‐mediated selection in natural populations. Here, we analysed ddRAD sequencing data (21,892 SNPs) in conjunction with geographic climate variation to search for signatures of adaptive differentiation in twelve populations of the bank vole (Clethrionomys glareolus) distributed across Europe. To identify the loci subject to selection associated with climate variation, we applied multiple genotype‐environment association methods, two univariate and one multivariate, and controlled for the effect of population structure. In total, we identified 213 candidate loci for adaptation, 74 of which were located within genes. In particular, we identified signatures of selection in candidate genes with functions related to lipid metabolism and the immune system. Using the results of redundancy analysis, we demonstrated that population history and climate have joint effects on the genetic variation in the pan‐European metapopulation. Furthermore, by examining only candidate loci, we found that annual mean temperature is an important factor shaping adaptive genetic variation in the bank vole. By combining landscape genomic approaches, our study sheds light on genome‐wide adaptive differentiation and the spatial distribution of variants underlying adaptive variation influenced by local climate in bank voles.
Novel Ruthenium‐based Nitrosyl Complexes: NO Donation and Vasorelaxant Potentials for Cardiovascular Therapeutics
Authors: Gouveia Júnior Florêncio S. , de Sousa Allandeiverson S. , da Silva Renally B. , Rocha Danilo G. , Teixeira Edson H. , Odorico de Moraes Filho Manoel , Jamacaru Francisco Vagnaldo F. , Serra Azul Monteiro Helena , Jorge Roberta Jeane B. , Wink David A. , de Sousa Eduardo Henrique S. , de F. Lopes Luiz Gonzaga 
Published: March 2024

AbstractNitrosyl ruthenium complexes have emerged as promising platforms for the controlled delivery of nitric oxide (NO) and nitroxyl (HNO), both of which possess significant therapeutic implications. Considering this scenario, we synthesized and characterized the metal complex cis‐[RuNO(phen)2(2MIM)]3+ and its precursors, where phen and 2MIM correspond to 1,10‐phenantroline and 2‐methylimidazole, respectively. Comprehensive structural elucidation was undertaken using a combination of spectroscopic and electrochemical methodologies, including XANES/EXAFS experiments. This structural data was further validated through DFT computational analyses. We demonstrated that such compound can release NO and HNO in the presence of thiol‐based substrates. Not only this, but the same metal complex can also delivery nitric oxide under irradiation with visible light (λ=460 nm). The nitrosyl complex and its derivatives displayed marked vasodilatory capabilities as evidenced in assays involving isolated rat aorta rings. They also exhibited commendable antioxidant activity in free radical scavenging assays. Collectively, based on these data, this nitrosyl ruthenium compound is a potential therapeutic candidate, especially in the field of cardiovascular pathology like atherosclerosis, thereby deserving further in‐depth investigations.
Palladium‐Catalyzed C8‐Fluoroalkylation and C8‐Fluoroalkenylation of Naphthalenes by C−H Activation
Authors: Amistadi‐Revol Hugo , Tremblais Julie , Casaretto Nicolas , Prévost Sébastien 
Published: March 2024

AbstractIn this study, two novel C8‐functionalization methods of 1‐carbonylnaphthalenes were developed. Leveraging iodonium triflates as coupling partners, we disclose palladium‐catalyzed C8‐fluoroalkylation and C8‐fluoroalkenylation processes. These protocols exhibit broad applicability across diverse naphthalene derivatives, owing to carbonyl directing groups at the C1 position which can be retained for subsequent applications or selectively removed, enhancing the versatility of the developed methodologies.
Perceived social mobility and system justification predict greater well‐being, but less prosocial behaviour
Authors: Park Lora E. , Ward Deborah E. , Jung Han Young , Weng Jennifer 
Published: March 2024

AbstractIn the present research, we propose that perceptions of social mobility (PSM) are beneficial for oneself but costly to others. Supporting this idea, people who were led to think that social mobility in society is probable (vs. improbable) (Study 1a/b, N = 754; Study 3a/b, N = 938) or held this belief at a dispositional level (Study 2a/b, N = 877) showed greater endorsement of system justifying beliefs, which was related to greater happiness and life satisfaction. However, the more people perceived social mobility and justified the system, the less willing they were to help others in need, and this was especially true for those who thought the current economic system was fair and legitimate. Thus, while greater perceived social mobility is related to increased personal well‐being through justification of the sociopolitical system, it predicts less desire to help others due to increased support of the economic status quo.
Self‐objectification and sexual dysfunction among women: Testing and extending objectification theory
Authors: Kahalon Rotem , Klein Verena , Alon Shani , Shnabel Nurit 
Published: March 2024

AbstractObjectification theory predicts that women's self‐objectification should lead to sexual dysfunction, yet previous studies failed to provide consistent support for this prediction. The present research—which used two sufficiently powered samples and a self‐objectification measurement (SOBBS) with improved psychometric qualities and content validity than previous measurements—found support for the expected association between self‐objectification and sexual dysfunction among heterosexual women in Israel and the United States (N = 404 and 366, Mage = 30.59 and 36.93, respectively). We also examined two novel potential mediators of this association, entitlement for pleasure and sexual agency (i.e., the capability to express sexual desires and boundaries), and found that the latter mediated the link between self‐objectification and sexual dysfunction. The mediators originally proposed by objectification theory (i.e. appearance anxiety, body shame, awareness of internal body states and flow) failed to mediate this link. Theoretical and methodological implications are discussed.
Effects and considerations of multiplexing ForenSeq Kintelligence libraries with a negative control
Authors: Bali Gunmeet Kaur , Cuenca Daniela , Wallin Jeanette 
Published: March 2024

AbstractThe negative template control or negative amplification control has been an essential component of the forensic DNA analysis workflow that helps monitor contamination. As such, the inclusion of a negative control in forensic DNA analysis has been a requirement for all laboratories audited under the FBI's Quality Assurance Standards. As massively parallel sequencing (MPS) becomes more conventional in forensic laboratories, considerations for the inclusion of a negative control in every sequencing run can be evaluated. Although the inclusion of a negative control in library preparation and the first sequencing run has a practical function, there is less utility for its inclusion in all subsequent sequencing runs for that library preparation. Although this is universal to all MPS assays, it is most relevant for an assay that has a low sample multiplexing capacity, such as the ForenSeq Kintelligence Kit (Qiagen/Verogen, Inc.). The ForenSeq Kintelligence Kit is an investigative genetic genealogy (IGG) sequencing‐based assay that targets 10,230 forensically relevant single‐nucleotide polymorphisms. The manufacturer recommends multiplexing 3 libraries per sequencing run, which includes controls. The purpose of this study was to investigate the effect of the inclusion of a negative control in every Kintelligence sequencing run. We observed that the library generated from a negative amplification control will take 7%–14% of the run output. The loss of sequencing space taken by a negative control decreased the available output for DNA‐containing samples, leading in some cases to allele or locus dropout and accompanying higher numbers of sixth to seventh order unknown associations in GEDmatch PRO.
Transcriptomics-based points of departure for Daphnia magna exposed to 18 Per- and polyfluoroalkyl substances
Authors: Villeneuve Daniel L , Blackwell Brett R , Bush Kendra , Harrill Joshua , Harris Felix , Hazemi Monique , Le Michelle , Stacy Emma , Flynn Kevin M 
Published: March 2024

Abstract
Per- and polyfluoroalkyl substances (PFAS) represent a large group of contaminants of concern based on their widespread use, environmental persistence, and potential toxicity. Many traditional models for estimating toxicity, bioaccumulation, and other toxicological properties are not well suited for PFAS. Consequently, there is a need to generate hazard information for PFAS in an efficient and cost-effective manner. In the present study, Daphnia magna were exposed to multiple concentrations of 22 different PFAS for 24 h in a 96-well plate format. Following exposure, whole-body RNA was extracted and extracts, each representing five exposed individuals, were subjected to RNA sequencing. Following analytical measurements to verify PFAS exposure concentrations and quality control on processed cDNA libraries for sequencing, concentration-response modeling was applied to the data sets for 18 of the tested compounds, and the concentration at which a concerted molecular response occurred (transcriptomic point of departure; tPOD) was calculated. The tPODs, based on measured concentrations of PFAS, generally ranged from 0.03 to 0.58 µM (9.9–350 µg/L; interquartile range). In most cases, these concentrations were two orders of magnitude lower than similarly calculated tPODs for human cell lines exposed to PFAS. They were also lower than apical effect concentrations reported for seven PFAS for which some crustacean or invertebrate toxicity data were available, although there were a few exceptions. Despite being lower than most other available hazard benchmarks, D. magna tPODs were, on average, four orders of magnitude greater than the maximum aqueous concentrations of PFAS measured in Great Lakes tributaries. Overall, this high-throughput transcriptomics assay with D. magna holds promise as a component of a tiered hazard evaluation strategy employing new approach methodologies.
Agaricus griseovariegatus: A new record of genus Agaricus for Indian mycobiota from Jammu and Kashmir, India
Authors: Ahamed Masood , Saini Sakshi , Sharma Yash Pal 
Published: March 2024

AbstractIn the present communication, a species of Agaricus (A. griseovariegatus) belonging to A. sect. Xanthodermatei has been described from North‐western Himalaya of Union Territory of Jammu and Kashmir, India. This species is humicolous and found on dead decaying leaves of walnut. It is characterized by its appressed olive‐gray squamules, broad radial fissures on the pileus, floccose annulus, faintly yellow context, phenolic odor, and bisporic to tetrasporic basidia. This species is reported here as a novel addition to India's macrofungal flora. Its morphology, anatomy, and phylogenetic relationships based on nrITS sequences are all described in detail here.
The protective barrier role of satellite glial cells in sensory ganglia
Authors: Qarot Eman , Guan Yun , Hanani Menachem 
Published: March 2024

AbstractNeurons in sensory ganglia are wrapped completely by satellite glial cells (SGCs). One putative function of SGCs is to regulate the neuronal microenvironment, but this role has received only little attention. In this study we investigated whether the SGC envelope serves a barrier function and how SGCs may control the neuronal microenvironment. We studied this question on short‐term (<24 h) cell cultures of dorsal root ganglia and trigeminal ganglia from adult mice, which contain neurons surrounded with SGCs, and neurons that are not. Using calcium imaging, we measured neuronal responses to molecules with established actions on sensory neurons. We found that neurons surrounded by SGCs had a smaller response to molecules such as adenosine triphosphate (ATP), glutamate, GABA, and bradykinin than neurons without glial cover. When we inhibited the activity of NTPDases, which hydrolyze the ATP, and also when we inhibited the glutamate and GABA transporters on SGCs, this difference in the neuronal response was no longer observed. We conclude that the SGC envelope does not hinder diffusional passage, but acts as a metabolic barrier that regulates the neuronal microenvironment, and can protect the neurons and modulate their activity.
Combined simultaneous endoscopic endonasal and transcranial surgery using high‐definition three‐dimensional exoscope for malignant tumors of the anterior skull base
Authors: Makihara Seiichiro , Otani Yoshihiro , Uraguchi Kensuke , Shimizu Aiko , Murai Aya , Higaki Takaya , Akisada Naoki , Fujimoto Shohei , Makino Takuma , Ishida Joji , Fujii Kentaro , Yasuhara Takao , Ota Tomoyuki , Matsumoto Hiroshi , Ando Mizuo 
Published: March 2024

AbstractBackgroundAdvanced surgical interventions are required to treat malignancies in the anterior skull base (ASB). This study investigates the utility of endoscopic endonasal and transcranial surgery (EETS) using a high‐definition three‐dimensional exoscope as an alternative to traditional microscopy.MethodsSix patients with carcinomas of varying histopathologies underwent surgery employing the EETS maneuver, which synchronized three distinct surgical modalities: harvesting of the anterolateral thigh flap, initiation of the transnasal technique, and initiation of the transcranial procedure.ResultsThe innovative strategy enabled successful tumor resection and skull base reconstruction without postoperative local neoplastic recurrence, cerebrospinal fluid leakage, or neurological deficits.ConclusionThe integration of the exoscope and EETS is a novel therapeutic approach for ASB malignancies. This strategy demonstrates the potential of the exoscope in augmenting surgical visualization, enhancing ergonomics, and achieving seamless alignment of multiple surgical interventions. This technique represents a progressive shift in the management of these complex oncological challenges.