bluuebunny/crossref_metadata_2025_split huggingface dataset:
Altered dynamic functional network connectivity in herpes zoster patients and postherpetic neuralgia patients
Authors: Lv Huiting , Jiang Jian , Li Zihan , Xie Yangyang , Xiong Jiaxin , Kuang Hongmei , Jiang Xiaofeng , Hong Shunda , Gu Lili 
Published: March 2024

Abstract

Postherpetic neuralgia (PHN) is a neuropathic pain syndrome characterized by persistent burning or stinging pain, and its underlying pathogenesis is still unclear. Although conventional resting-state magnetic resonance imaging (rs-fMRI) studies have revealed abnormal resting-state functional connectivity (rsFC) in PHN patients, dynamic functional connectivity (dFC) remains unexplored. In this paper, a sliding time window method was used to generate a dFC matrix, and rs-fMRI data from 55 PHN patients, 55 Herpes Zoster (HZ) patients, and 50 healthy controls (HCs) were analyzed. Machine learning was used to determine whether these abnormal dFC values could be used as neuroimaging markers of the transition from HZ to PHN. All dFC matrices were clustered into two reoccurring states, and the state transition metrics were obtained. We found that patients with PHN were in State 1, which is characterized by weak connections between the networks, more often than patients with HZ (p < 0.05). We also found that in State 1, compared with that in HCs, the dFC between the BGN and SN in HZ patients increased. In State 2, the dFC of PHN patients was lower than that of HZ patients and HCs, and the dFC was mainly observed in the DMN, SN, DAN, VN and LN. The results of the SVM classifier revealed that the change in dFC between the BGN and DMN may be a strong neuroimaging marker of the transition from HZ to PHN. These findings further our understanding of the neuropathological mechanism of PHN.
Advancing LED Technology: The FDCSP Element's Breakthrough in Mini and Micro-LED Packaging and Backlight Module Enhancement
Authors: Chen Jo-Hsiang , Huang Che-Hsuan , Lee Tzu-Yi , Chen Fang-Chung , Kao Tsung Sheng , Kuo Hao-Chung 
Published: March 2024

Abstract

In this research, we introduce an advanced methodology for the calculation of bulk light sources tailored for free-form surface design, focusing on the principle of energy conservation. This method is especially relevant for the evolving needs of micro-LED packaging, highlighting its potential in this burgeoning field. Our work includes the development of an algorithm for creating Freeform-Designed Chip-Scale Package (FDCSP) components. These components seamlessly integrate LEDs and lenses, underscoring our commitment to advancing free-form surface design in chip-level packaging. By adhering to the principle of energy conservation, our approach facilitates a meticulous comparison of simulation outcomes with predefined target functions. This enables the iterative correction of discrepancies, employing layering techniques to refine the design until the simulated results closely align with our goals, as demonstrated by an appropriate difference curve. The practical application of these simulations leads to the innovative design of FDCSP devices. Notably, these devices are not just suitable for traditional applications in backlight modules but are explicitly optimized for the emerging sector of micro-LED packaging. Our successful demonstration of these FDCSP devices within backlight modules represents a significant achievement. It underscores the effectiveness of our design strategy and its expansive potential to transform micro-LED packaging solutions. This research not only contributes to the theoretical understanding of energy conservation in lighting design but also paves the way for groundbreaking applications in micro-LED and backlight module technologies.
Extraction and characterization of antibacterial and antibiofilm Carbon nanodots from Havan smoke
Authors: Var Challa Sri , Gopal Judy 
Published: March 2024

Abstract
From time immemorial, smoke of medicinal plants has been widely reported for curing disorders. Smoke produced from natural substances has been used extensively in many cultures and rituals. Burning of havan samagri (mixture of wood and odoriferous and medicinal herbs) is a popular practice during religious rituals. In the following study, carbon nanodots were extracted from Havan smoke and their identity was confirmed by characterizing them using standard characterization analytics. The antibacterial activity of the carbon nanodots extracted from the smoke was evaluated by testing them against pathogenic coliforms and oral bacteria. Further carbon coatings were developed by dip coating method using carbon nanodot suspensions obtained from Havan smoke. The antibiofilm ability of these carbon coatings was validated against Staphylococcus aureus biofilms. The results confirmed the antibacterial and antibiofilm activity of the Havan smoke-derived carbon nanodots. This is the first report that highlights the extraction of carbon nanodots from Havan smoke and discusses it antibacterial property.
Effects of paired donors’ and recipients’ preoperative serum sodium on the prognosis of liver transplantation
Authors: Chen Yabin , Li Hao , Zhang Menggang , Wu Zeyu , Fang Haoran , Wen Peihao , Zhang Jiakai , Guo Wenzhi 
Published: March 2024

Abstract

Background
Dysnatremia is common in donors and recipients of liver transplantation (LT). However, the influence of dysnatremia on LT prognosis remains controversial. This study aimed to investigate effects of paired donors’ and recipients’ serum sodium on LT prognosis.
Methods
We retrospectively reviewed 248 patients who underwent orthotopic LT at our center between January 2016 and December 2018. Donors and recipients perioperative and 3-year postoperative clinical data were included. Delta serum sodium was defined as the donors’ serum sodium minus the paired recipients’ serum sodium.
Results
Donors with serum sodium > 145 mmol/L had significantly higher preoperative blood urea nitrogen (BUN) (P < 0.01) and creatinine (Cr) (P < 0.01) than others, preoperative total bilirubin (TBIL) (P < 0.01), direct bilirubin (DBIL) (P < 0.01), BUN (P < 0.01), Cr (P < 0.01) were significantly higher in the hyponatremia group of recipients than the other groups, but both of donors’ and recipients’ serum sodium had no effect on the LT prognosis. In the delta serum sodium < 0 mmol/L group, TBIL (P < 0.01) and DBIL (P < 0.01) were significantly higher in postoperative 1 week than the other groups, but delta serum sodium had no effect on the postoperative survival rates.
Conclusions
Dysnatremia in donors and recipients of LT have no effect on postoperative survival rates, hepatic and renal function, but recipients with higher serum sodium than donors have significantly poor hepatic function at 1 week postoperatively.
The associations between burnout with depression and anxiety among healthcare workers: A network analysis
Authors: Ge Qiqi , Feng Ji-Feng , Liu Yan-Jun , Wu Yi-Lin , Hu Ting , Zhou Xiao-Na , Liu Yun-E , Wang Wei 
Published: March 2024

Abstract

Healthcare professionals encounter notably elevated levels of work-related stress in comparison to individuals employed in other sectors. Such work stress frequently contributes to the development of burnout, depression, and anxiety among healthcare workers. However, there exists a lack of consensus in research regarding the associations between burnout with depression and anxiety in this population, impeding endeavors aimed at enhancing their mental well-being. The present study constructed a comprehensive network model that encompasses job burnout, depression, and anxiety, provided a clear depiction of the interrelationship among burnout, depression, and anxiety in symptomatic level. The findings indicate that "Psychomotor Problems", "Irritability", and "Collapse" function as bridge symptoms connecting burnout, depression, and anxiety network. The result recommended that interventions prioritize the alleviation of the "Irritability" symptom in individuals with anxiety, as this has the potential to reduce the risk of developing depression. Furthermore, the study constructed a network using principal components analysis which revealed that burnout symptoms cannot be distinguished from depressive and anxiety symptoms.
Assessment of the effectiveness of high-pressure water jet machining generated using self-excited pulsating heads
Authors: Szada-Borzyszkowska Monika , Kacalak Wojciech , Banaszek Kamil , Pude Frank , Perec Andrzej , Wegener Konrad , Królczyk Grzegorz 
Published: March 2024

Abstract

The article provides a analysis of pulsating water jets, utilizing three distinct head models. It research the impact of tool geometry on water velocity and pressure scientifically. The emergence of vortices due to increased flow through additional holes is identified as the primary cause of the observed pulsations. Laboratory tests contributed measured impulses at various pressures, revealing a direct correlation between longer impulses (ranging from 15 mm to 60 mm) and increased erosion potential. Notably, at 35 MPa, longer impulses exhibited a minor decrease in force deviation by 0.068. Additionally, the research indicates that pressure variations affect impulse frequencies: 0.55 ms at 15 MPa and approximately 1 ms at higher pressures, highlighting the dynamic nature of water streams based on applied pressures. The study emphasizes the exploitable aspects of self-excited pulsating heads, meticulously examining their design, parameter variations, and their impact on impulse generation. Such comprehensive research serves as a fundamental for enhancing the efficiency of surface pulsating water jet.
A Mathematical Explanation for Why Ratio-Based Isotopic Analyses are Commonly Misleading: Theory
Authors: Moots Kate , Nguyen Christina P. , Nguyen Catherine , Camacho Frank , Lindstrom Dan , Righetti Timothy L. 
Published: March 2024

Abstract

Stable mass isotopic ratios (such as 13C:12C, 15N:14N, 18O:16O 87Sr:86Sr and 34S:32S) are used to interpret archaeological, climate change, ecological, geological, and physiological studies. Most isotopic reports evaluate changes in observed isotopic ratios or ratio-based expressions over time or among treatments. To address concerns that ratios or ratio-based expressions may not produce conclusions that support known physiological or ecological principles, source (isotopic ratio of the material being added or lost) analyses are proposed as an alternative to statistically analysing observed isotopic ratios. Mathematically defined relationships between observed ratios, backgrounds (isotopic ratio of a system before any loses or gains), sources and total element concentrations as well as denominator vs. numerator relationships are presented. These mathematical relationships suggest that source-based approaches often produce conclusions that differ from ratio-based evaluations. Total element concentrations, necessary for source analyses, are presented in less than half of isotopic publications. Without evaluating total element, relative background and source ratios cannot be determined. Even, when total element data is available, researchers rarely conduct source analyses. This is unfortunate because determining sources solves most interpretive issues. Our goal is to advocate better methods when analyzing isotopic ratios in the thousands of mass isotope publications annually produced.
MiR-185-5p Inhibits the Proliferation, Migration and Invasion of Gastric Carcinoma Cells Through Targeting the SMAD3 Pathway
Authors: Wu Guobin , Yang Anbo , Lai Shichao , Wang Ju , Wang Jiao 
Published: March 2024

Abstract

Objective: To explore the effects of miR-185-5p on the migration, invasion and proliferation of human gastric carcinoma HGC-27 cells.
Methods: HGC-27 cells cultured to the logarithmic growth phase were divided into NC mimic group, miR-185-5p mimic (miR-mimic) group, NC inhibitor group and miR-185-5p inhibitor (miR-inhibitor) group. The changes in the migration and invasion capabilities of HGC-27 cells were detected by wound healing assay and Transwell assays, respectively. The viability and proliferation capability of HGC-27 cells in each group were assessed by CCK-8 assay and colony formation assay, respectively. The relative protein expressions of TGF-β1, SMAD3, MMP2, MMP3, MMP9, Cyclin D1, PCNA and P21 in HGC-27 cells were determined using Western blotting.
Results: After HGC-27 cells were transfected with miR-inhibitor, the protein expressions of MMP2, MMP3, MMP9, Cyclin D1, PCNA and P21 all rose,and the relative protein expression of TGF-β1 and SMAD3 decreased, and the migration distance of HGC-27 cells, the numbers of cells passing through the lower chamber and the basement membrane, the cell viability and the number of colonies formed were significantly increased. However, the above phenomena were reversed after overexpression of miR-185-5p in vitro.
Conclusion: The overexpression of miR-185-5p can, through targeting the SMAD3 pathway, inhibit the proliferation, migration and invasion of GC cells.
Highly Effective Bifunctional Electrocatalysts: Synthesizing NiCo 2 O 4 Nanostructures via Chemical Precipitation for Enhanced Oxygen Evolution and Reduction Reaction
Authors: Sasmal Ananta , Gogoi Dipankar , Das T D 
Published: March 2024

Abstract
In this investigation, we successfully produced NiCo2O4 nanostructures using a simple chemical precipitation method, wherein we adjusted molarity concentration of sodium bicarbonate (NaHCO3) and precursor ratios of Ni and Co. Analysis of surface features revealed a diverse range of shapes, including particles, flowers, rods, and flakes. Notably, the NiCo2O4 nanorods (NCO3) demonstrated a significant threefold increase in BET surface area compared to NCO5. The alterations observed in the physical and chemical characteristics significantly influenced the electrocatalytic efficacy in alkaline environments for both the oxygen evolution reaction (OER) and oxygen reduction reaction (ORR). In the context of the oxygen reduction reaction, NCO5 displayed a commencement potential of 0.72 V compared to the reversible hydrogen electrode (RHE), surpassing NCO4 by 110 mV, albeit falling short by 90 mV when compared to Pt/C, the standard benchmark material with a potential of 0.82 V. In terms of OER, NCO3 displayed a potential difference of 152 mV@10mA/cm2 compared to other NiCo2O4 materials and Pt/C. The increased level of activity observed can be attributed not only to the increased surface area but also to enhancements in electrical properties. This is supported by the lower charge transfer resistance measured in NCO3 (215.2 Ω.cm2) compared to NCO5 (350.2 Ω.cm2) as revealed by electrochemical impedance spectroscopy (EIS).
Field perturbation facilitates parallel electron paramagnetic resonance detection
Authors: Lee Chun Him , Korvink Jan , Jouda Mazin 
Published: March 2024

Abstract
Electron paramagnetic resonance (EPR) spectroscopy stands out as a powerful analytical technique with extensive applications in the fields of biology, chemistry, physics, and material sciences. It proves invaluable for investigating the molecular structure and reaction mechanisms of substances containing unpaired electrons, such as metal complexes, organic and inorganic radicals, and intermediate states in chemical reactions. However, despite their remarkable capabilities, EPR systems face significant limitations in terms of sample throughput, as current commercial systems only target the analysis of one sample at a time. Here we introduce a novel scheme for conducting ultra-high frequency (UHF) continuous-wave EPR (CW EPR) targeting the EPR spectroscopy of multiple microliter volume samples in parallel. Our proof-of-principle prototype involves two decoupled detection cells equipped with high qualty factor Q = 104 solenoidal coils tuned to 488MHz and 589MHz, ensuring a significant frequency gap for effective radio frequency (RF) decoupling between the channels. To further enhance electromagnetic decoupling, an orthogonal alignment of the coils was adopted. The paper further presents an innovative radiofrequency circuit concept that utilizes a single physical RF channel to simultaneously conduct parallel EPR on up to eight cells. Parallel EPR experiments on two BDPA samples, each with a sample volume of 18.3 μL, registered signal-to-noise ratios of 255 and 252 for the two EPR measurement cells, with no observable coupling. The showcased prototype, built using cost-effective commercially available fabrication technology, is readily scalable and represents an initial step with promising potential for advancing sample screening with high-throughput parallel EPR.
Exploring the Relationship Between Anorexia and Therapeutic Efficacy in Advanced Lung Cancer Treatment: A Retrospective Study
Authors: Doshita Kosei , Naito Tateaki , Matsuda Suguru , Morita Meiko , Sekikawa Motoki , Miura Keita , Kodama Hiroaki , Yabe Michitoshi , Morikawa Noboru , Iida Yuko , Mamesaya Nobuaki , Kobayashi Haruki , Ko Ryo , Wakuda Kazushige , Ono Akira , Murakami Haruyasu , Kenmotsu Hirotsugu , Takahashi Toshiaki 
Published: March 2024

Abstract
Background
Chemotherapy-induced anorexia is frequently observed in patients with advanced lung cancer who are receiving chemotherapy. This study explored the relationship between chemotherapy-induced anorexia and therapeutic outcomes in patients with stage IV non-small cell lung cancer undergoing platinum-based chemotherapy combined with immune checkpoint inhibitors.
Methods
We retrospectively reviewed the medical records of 106 patients with stage IV non-small cell lung cancer treated with platinum-based chemotherapy combined with immune checkpoint inhibitors between January 2019 and October 2022. The incidence of weight loss and its association with treatment efficacy was assessed in the chemotherapy-induced anorexia group. Chemotherapy-induced anorexia and chemotherapy-induced nausea and vomiting were evaluated using Common Terminology Criteria for Adverse Events version 5.0. Progression-free and overall survival were used to measure treatment efficacy.
Results
Chemotherapy-induced anorexia was observed in 13.2% of patients. Patients with chemotherapy-induced anorexia showed significant weight loss at 6 and 9 weeks after treatment initiation compared to those in the non-chemotherapy-induced anorexia group. Progression-free and overall survival were shorter in the chemotherapy-induced anorexia group than in the non-chemotherapy-induced anorexia group, but the difference was not statistically significant.
Conclusions
Chemotherapy-induced anorexia was associated with significant weight loss and reduced treatment efficacy in patients with stage IV non-small cell lung cancer. These findings suggest the need for aggressive supportive therapy for chemotherapy-induced anorexia to prevent weight loss and maintain therapeutic efficacy during platinum-based chemotherapy combined with immune checkpoint inhibitors.
Overexpression of miR-126-5p in the serum of patients with systemic arterial hypertension is correlated with creatinine and platelets
Authors: Improta-Caria Alex Cleber , Nonaka Carolina Kymie Vasques , Aras Marcela Gordilho , Nunes Bianca Almeida , De Sousa Ricardo Augusto Leoni , Oliveira Edilamar Menezes , Roever Leonardo , Souza Bruno Solano Freitas , Aras-Júnior Roque 
Published: March 2024

Abstract

Background: Systemic arterial hypertension is a multicausal and multifactorial disease of high prevalence worldwide. The development, progression, and damage of target organs are associated not only with genetic and environmental factors, but also epigenetic factors, such as the regulation by microRNAs (miRNAs). MiRNAs – including miRNA-1-3p, miRNA-21-5p and miRNA-126-5p have been described as potential biomarkers in hypertension, type 2 diabetes and obesity, but their role of in the development and progression of the disease has been little explored. In the present study, we analyzed the expression of these three miRNAs in the serum of hypertensive, diabetic and obese patients compared with a healthy group and correlated with clinical and laboratory parameters.
Methods:Using RT-qPCR, the expression of miRNA-1-3p, miRNA-21-5p and miRNA-126-5p was analyzed in the serum of 50 participants, control (n = 8), hypertensive only (n = 21), hypertensive in association with diabetes and obesity (n = 21).
Results:The expression of miRNA-126-5p was significantly high in the hypertensive group when compared to the control group (p= 0.0170), however there was no statistical difference when compared to the hypertensive, diabetic and obese group. MiRNA-1-3p and miRNA-21-5p showed no statistical differences between groups. The correlation analysis showed a positive correlation of miRNA-126-5p with creatinine and a negative correlation with platelets.
Conclusion: This study demonstrated that miRNA-126-5p is overexpressed in the serum of hypertensive patients, and may have a potential as a biomarker of early target kidney injury.
Clinicopathological concordance of clinicians, Chat-GPT4 and ORAD for odontogenic keratocysts and tumours referred to a single New Zealand Centre- A 15-year retrospective study.
Authors: Kim Paul , Seo Benedict , De Silva Harsha 
Published: March 2024

Abstract

Background: This research aimed to investigate the concordance between clinical impressions and histopathologic diagnoses made by clinicians and artificial intelligence tools for odontogenic keratocyst (OKC) and Odontogenic tumours (OT) in a New Zealand population from 2008-2023.
Methods: Histopathological records from the Oral Pathology Centre, University of Otago (2008-2023) were examined to identify OKCs and OT. Specimen referral details, histopathologic reports, and clinician differential diagnoses, as well as those provided by ORAD and Chat PT-4, were documented. Data were analyzed using SPSS, and concordance between provisional and histopathologic diagnoses was ascertained.
Results: Of the 34,225 biopsies, 302 and 321 samples were identified as OTs and OKCs. Concordance rates were 43.2% for clinicians, 45.6% for ORAD, and 41.4% for CHAT-GPT4. Surgeons achieved higher concordance rate (47.7%) compared to non-surgeons (29.82%). Odds ratio of having concordant diagnosis using CHAT-GPT and ORAD were between 1.4-2.8 (p<0.05). In differentiation between Ameloblastoma and OKC, CHAT-GPT4 had highest sensitivity at 75.9% and accuracy of 82.5%. For clinicians and ORAD the corresponding values were 66.7%/86.8% and 66.7%/84.9%, respectively.
Conclusion: Clinicians with surgical training achieved higher concordance rate when it comes to OT and OKC. CHAT-GPT4 and Bayesian approach (ORAD) have shown potential in enhancing diagnostic capabilities.