bluuebunny/crossref_metadata_2025_split huggingface dataset:
On the acid glycoproteins of serum and synovial fluid in rheumatoid arthritis
Authors: Nettelbladt Erik , Sundblad Lars 
Published: February 2007

AbstractOrosomucoid, haptoglobin, PCA‐soluble glycoproteins, and sialic acid have been determined in serum and synovial fluid in rheumatoid arthritis. The increase in the serum content of sialic acid in rheumatoid arthritis is largely due to an increase in orosomucoid and haptoglobin. There is no indication that these glycoproteins arise from peripheral production in the inflammatory synovial tissue. The presence in synovial fluid of other glycoproteins of tissue origin, however, can not be excluded.
Depolymerization of hyaluronic acid by the ORD reaction
Authors: Pigman Ward , Rizvi S. , Holley Howard L. 
Published: February 2007

AbstractHyaluronic acid is shown to be degraded irreversibly by oxygen in the presence of „reducing agents”︁ such as ascorbic acid, thiols, or ferrous ions. The degradation could be inhibited by substances such as sodium diethyldithiocarbamate, penicillamine, and thiourea. The reaction is called the ORD reaction (oxidative‐reductive depolymerization). It is suggested that the reaction may control tissue permeability, in vivo, and play a part in arthritic processes.
The effect of hyperventilation on rheumatoid arthritis
Authors: Kahn Fredrick H. , Simmons Daniel H. , Weinberger Howard J. 
Published: February 2007

AbstractClinical improvement in rheumatoid arthritis has been observed in certain situations associated with hyperventilation. A consistent pharmacological effect of massive aspirin therapy is hyperventilation. In this preliminary study, the authors tested the hypothesis that the symptomatic improvement with aspirin therapy in rheumatoid arthritis is related to the ventilatory effects of the drug. Hyperventilation induced by using a Drinker respirator simulated some of the clinical effects of massive aspirin therapy. Improvement was correlated better with alveolar pCO2 levels than with aspirin dosage or serum salicylate levels. Significant but unexplained improvement in sedimentation rates occurred after respirator hyperventilation.
Serologic methods employing F–II reactant as an aid to diagnosis of rheumatoid arthritis
Authors: Howell David S. , Vaughn Phyllis P. , Broome Betty L. 
Published: February 2007

AbstractSera of 129 patients with rheumatoid arthritis and 512 patients with variants of rheumatoid arthritis, osteoarthritis, gout, and other diseases were subjected to a battery of serologic procedures. With no apparent loss of specificity, the test employing a modified hydrochloric acid method of euglobulin fractionation produced a significantly greater frequency of positive reactions in patients with rheumatoid artbritis.
Involvement of the hips in juvenile rheumatoid arthritis
Authors: Jacqueline F. , Boujot A. , Canet L. 
Published: February 2007

AbstractRheumatoid coxitis occurring in childhood develops differently from that occurring at an adult age. Inflammation quickly leads to considerable stiffness, and even to bony ankylosis, but does not cause extensive destruction. The functional disturbances set up by the inflammation interfere with the development of the hip joints, and the extent of the resultant morphologic abnormalities depends on the earliness of onset and the severity of the disturbances. Luxation and subluxation due to malformations in severe coxitis developed before the age of eight contrast with the acetabular protrusion of destructive coxitis in the adult.
Evaluation of rheumatoid factor tests
Authors: Waller Marion V. , Decker Barry , Toone Elam C. , Irby Robert , Curry N. H. 
Published: February 2007

AbstractFourteen (4 per cent) of 340 blood donors showed the presence of rheumatoid factor and some of these were studied in detail. One young donor with very high titers of rheumatoid factor and a 22S component, followed for over two years, has shown no clinical evidence of disease. The sensitized human cell test compares favorably with latex reagent. Both methods are more sensitive and less specific than the sensitized sheep cell test.
Inhibition of glucosamine‐6‐PO4 synthesis by salicylate and other anti‐inflammatory agents in vitro
Authors: Bollet Alfred Jay 
Published: February 2007

AbstractSodium salicylate and phenylbutazone were found to inhibit the enzyme which synthesizes glucosamine‐6‐phosphate. Enzyme in homogenates from connective tissue was more sensitive to this inhibitory effect than enzyme from liver homogenates. The known effects of antirheumatic agents and inflammation on mucopolysaccharide metabolism are reviewed.
Chloroquine and hydroxychloroyuine therapy in rheumatoid arthritis
Authors: Scull Edward 
Published: February 2007

AbstractOne hundred and ninety‐six poorly controlled rheumatoid arthritics were divided into three groups: 80 received chloroquine, 80 hydroxychloroquine, and 36 placebo, for an average duration of 24, 18 and 5.2 months respectively. Fifty‐seven per cent of patients were able to reduce or abolish their corticosteroid requirements while on the active drugs under study. It appeared from this study that chloroquine and hydroxychloroquine possessed definite antirheuniatic effect. No serious side effects were observed.
Comparative studies of serologic tests for rheumatoid disease. I. A comparison of a latex test and two erythrocyte agglutination tests in a random population sample
Authors: Ball J. , De Graaff R. , Valkenburg H. A. , Boerma F. Westendorp 
Published: February 2007

AbstractSera from a random sample of the population of Rotterdam were tested by a latex fixation test (LFT) in Leiden, a sensitized sheep cell agglutination test (SCAT) in Manchester and a human erythrocyte test (HEAT) in Groningen with an overall agreement of 93.3 per cent. In both rheumatoid and nonrheumatoid subjects sera were encountered which were positive in the cell tests but negative in the LFT and vice versa.
Comparative studies of serologic tests for rheumatoid disease. II. A comparison of the bentonite flocculation test and the sensitized sheep cell agglutination test
Authors: Ball J. , Bloch K. J. , Burch T. A. , Kellgren J. H. , Lawrence J. S. , Tsigalidou V. 
Published: February 2007

AbstractAgreement was obtained between the bentonite flocculation test (BFT) and the sensitized sheep cell agglutination test (SCAT) in 96 per cent of a random population sample and in 88 per cent of a clinical sample. Rarely, positive results were obtained in either test alone. The BFT was more often positive than the SCAT both in rheumatoid arthritis and in other syndromes.
The characteristics of human synovial tissue as seen with the electron microscope
Authors: Coulter William H. 
Published: February 2007

AbstractSynovial tissue specimens from the joints of nine persons, determined to be normal by light microscopic studies, were examined with the electron microscope. The arrangement of microstructures within the synovial cell indicates a moderate amount of metabolic activity, and appears to be clonsistent with the production of mucopcdysaccharides. A process of active transport was observed between the syno'vial cell and the joint space. Incorporation of collagen into the general architecture is also described, and the technical problems are considered.
A family study of rheumatoid (ankylosing) spondylitis
Authors: Karten Irving , DiTata Domenick , McEwen Currier , Tanner Martin 
Published: February 2007

AbstractClose relatives of patients with ankylosing spondylitis had that disease with significantly greater frequency than did similar relatives of non‐rheumatic controls. Rheumatoid arthritis on the other hand occurred no more often than in the controls. These relatives also gave positive tests for rheumatoid factors no more often than did the controls. The results support the view that hereditary factors are involved in the causation of ankylosing spondylitis but are different from those in rheumatoid arthritis.
The pathogenesis of mycoplasmal (PPLO) arthritis in rats
Authors: Ward John R. , Jones Russell S. 
Published: February 2007

AbstractThe pathogenesis of mycoplasmal polyarthritis in rats was investigated by cultural and morphologic procedures. Virulent Mycoplasma, injected intravenously, localized in joint structures. Synovitis appeared within several days and rapidly advanced to suppurative arthritis and periosteal new bone formation. Arthritis of interspinal articulations produced hind limb paralysis. Lesions resolved with fibrosis, ankylosis and remodeling of new bone. Histologically, mycoplasmal arthritis resembled other forms of experimental suppurative arthritis, distinguishable only by isolation of the pathogenic agent.
Synovial fluid lipids in rheumatoid and osteoarthritis
Authors: Chung A. C. , Shanahan J. R. , Brown E. M. 
Published: February 2007

AbstractJoint fluid and serum from rheumatoid and osteoarthritic patients revealed essentially normal values for serum lipids, but phospholipid and cholesterol/phospholipid (dp) ratios for synovial fluid resembled lipoprotein fractions of density < 1.063. Data bore no relationship to the type of arthritis. The findings indicate a qualitative difference between serum and joint lipids and pose a question of the nature of handling of fats by inflamed synovial membrane.
A comparative roentgenologic study of rheumatoid arthritis and rheumatoid (ankylosing) spondylitis
Authors: Dilsen Nihat , McEwen Currie , Poppel Maxweell , Gersh William J. , DiTata Dominick , Carmel Philip 
Published: February 2007

AbstractComparative roentgenologic and clinical studies of 97 patients with ankylosing spondylitis and 98 with rheumatoid arthritis revealed marked differences between the two. Among the features showing the greatest differences were the frequency and degree of involvement of individual joints, sacroiliac damage, abnormalities of apophyseal joints, paravertebral calcification, abnormalities in the shape of vertebral bodies, and pelvic periostitis and osteitis.
Rheumatoid pleuritis
Authors: Schools George S. , Mikkelsen William M. 
Published: February 2007

AbstractThree patients are described in whom pleural effusion appeared to be a manifestation of rheumatoid arthritis. In each, needle biopsy demonstrated granulomatous pleural lesions resembling the subcutaneous rheumatoid nodule while extensive studies failed to reveal any evidence of infection or neoplasm. The presence of extremely low fluid sugar concentration is regarded as strongly suggestive of rheumatoid pleuritis.
Rubella arthritis and rheumatoid arthritis
Authors: Santor Thomas G. , Tanner Martin 
Published: February 2007

AbstractFourteen cases of rubella arthritis were followed between 2 and 5 years after the attack. All were women. None showed any clinical manifestation suggesting rheumatoid disease over this follow‐up period nor was there a positive reactor using the englobulin sensitized sheep cell agglutination method. One patient, the daughter of a rheumatoid patient, was, and still is, positive by the englobulin inhibition reaction. The authors conclude that there is no relationship between the two diseases.
Influence of griseofulvin upon acute gouty arthritis
Authors: Slonim Roberte R. , Howell David S. , Brown Harvey E. 
Published: February 2007

AbstractAntiphlogistic properties of griseofulvin, a fungistatic antibiotic, were demonstrated in patients with acute gouty arthritis. By use of moderate‐to‐high dosages, complete remissions appeared in 14 patients and partial remissions in 2 within 24 to 48 hours. Side effects of the drug were negligible.
Statistical study of variation in systemic and articular indexes
Authors: Lansbury John , Baier Howard N. , McCracken Stewart , Fettus George H. , Ecker Malcolm L. , Gaydos Thomas S. 
Published: February 2007

AbstractSerial appraisals of rheumatoid activity by the systemic and articular indexes, performed by seasoned observers on patients who were accustomed to this type of examination, show an interobserver variation no greater than inter‐laboratory variations in determinations made on stock samples for uric acid, albumin and hemoglobin. However, the variation found when medical students examined new patients was considerably higher. Interobserver variation was not significantly greater than intraobserver variation. The precision and sensitivity of the various items composing the indexes are compared.
Zoxazolamine as a uricosuric agent. II. Clinical evaluation in the treatment of gout
Authors: Reed Elizabeth B. 
Published: February 2007

AbstractZoxazolamine was a well‐tolerated and effective uricosuric agent in 20 gouty patients treated for 3 to 31 months. Cardiovascular disease adversely affected the uricosuric response. Increases in creatinine clearance during treatment indicate that gout nephropathy may be reversible. Evidence suggesting that inadequate fluid intake may hasten the development of renal complications in gout is presented.
The effect of hemodialysis on acute gouty arthritis
Authors: Duncan Howard , Elliott Walter , Horn David B. , Kerr David N. S. , Pearson Derek T. , Robson Alan M. 
Published: February 2007

AbstractA man with tophaceous gout was treated by hemodialysis on three occasions, starting 24 hours after the onset of an acute attack of arthritis. His plasma uric acid was reduced to sub‐normal levels for periods up to 8 hours and more than 8 Gm. of uric acid was removed. The course of the acute attack was uninfluenced by hemodialysis, suggesting that acute attacks of gout are not maintained by any dialyzable metabolite.
Studies on adjuvant‐induced polyarthritis in rats. II. Histogenesis of joint and visceral lesions
Authors: Jones Russell S. , Ward John R. 
Published: February 2007

AbstractMycobacterium butyricum in olive oil was injected intradermally and the sequential histologic changes in viscera and joints determined. Foci of suppuration in viscera occurred concomitantly with the onset of suppurative arthritis and periarthritis. The acute visceral lesions underwent healing by the time of onset of macroscopic polyarthritis. These observations are interpreted as evidence for an important infectious component in adjuvant‐induced disease.
Anti‐gamma globulin factors in liver disease
Authors: Bonomo Lorenzo , Lospalluto Joseph , Ziff Morris 
Published: February 2007

AbstractSera from patients with liver disease, showing positive reactions with human Fraction II (F‐II) were submitted to cation exchange chromatography. Rheumatoid factor‐like material, reacting only with F‐II and F‐II sensitized systems, was eluted at pH 6.0 and pH 7.0. In rheumatoid sera, activity was also eluted at pH 6.5. In the latter fraction, the active material reacted not only in F‐II sensitized systems but also with rabbit amboceptor sensitized sheep cells. The distribution of the activity of portal cirrhosis and infectious hepatitis sera between the pH 6.0 and pH 7.0 fractions appeared to differ. The rheumatoid factor‐like material of the serum of a patient with portal cirrhosis was isolated as a 19 S macroglobulin.
Phosphate transfer enzymes in cartilage
Authors: Eyring Edward J. , Anderson Carl E. , Ludowieg Julio 
Published: February 2007

AbstractAn enzymically stable powder prepared from embryonic chick cartilage has permitted demonstration and partial purification of pyruvate kinase and adenylate kinase for the first time in cartilage. Pyruvate kinase from cartilage catalyzes synthesis of UTP, a process of potential usefulness to mucopolysaccharide synthesis. It has also been possible to conclusively demonstrate the presence of glucose‐6‐phosphatase in several fractions of cartilage extract, including one rich in matrix mucopolysaccharide.
Clutton's joints with keratitis and periostitis a case report with histology of synovium
Authors: Argen Ralph J. , Dixon Allan St. John 
Published: February 2007

AbstractA case of Clutton's joints or chronic synovitis as a late manifestation of congenital syphilis is presented. Progressive patchy periostitis and interstitial keratitis were also present in this 19‐year‐old‐Negro girl. All three manifestations of the disease and the serology were apparently unaffected by penicillin therapy. The histology of the synovium is presented and illustrated.
Amopyroquin (Propoquin) in rheumatoid arthritis
Authors: Bartholomew Lee E. , Duff Ivan F. 
Published: February 2007

AbstractA controlled, double‐blind trial of amopyroquin vs. placebo has been completed in 15 patients with active, classical or definite rheumatoid arthritis.Improvement in all the parameters determined occurred while the patients were on amopyroquin. Grip strength, sedimentation rate, and Lansbury's indices showed statistically significant improvement while on amopyroquin. Improvement in the 50‐foot walk and A.R.A. functional capacity approached statistical significance.Amopyroquin was well tolerated, but asymptomatic elevation of SGOT occurred in four patients and appeared to be related to the drug. Other tests of liver function remained normal.
Passive transfer of antinuclear activity in immunologically tolerant animals
Authors: Clark Richard F. , Burkhart Cecil R. , Bates Hampton R. 
Published: February 2007

AbstractRats made immunologically tolerant of human plasma proteins were inoculated with sera from patients with systemic L. E. The L. E. cell phenomenon was reproduced in the blood of these animals. The duration of activity of the transferred antinuclear factors was observed to be very transient in contrast to the relatively long persistence of human gamma globulin in the rat sera.
Rupture of the calcified anterior spinal ligament in the thorax
Authors: Evans Harold W. 
Published: February 2007

AbstractTrauma (automobile accident) produced rupture of the anterior spinal ligament in the thoracic area with concomitant anterior separation of the adjacent vertebrae in each of two men who had rheumatoid spondylitis. This injury is unusual. The pain due to it complicated medical management of other disorders and injuries.
Simultaneous salicylate concentrations in synovial fluid and plasma in rheumatoid arthritis
Authors: Rosenthal Robert K. , Bayles Theodore R. , Fremont‐Smith Kenneth 
Published: February 2007

AbstractTotal, free (diffusible) and proteinbound salicylate concentrations were determined in synovial fluid samples obtained from 12 patients with rheumatoid arthritis, and compared with simultaneously obtained plasma concentrations. Free salicylate concentrations were essentially identical in the two fluids, implying complete equilibrium. Both the total and protein‐bound salicylate concentrations were consistently lower in the synovial fluids than in the corresponding plasmas; this difference may be explained by the lower albumin concentration in the joint fluid.
Evolution of the anti‐Gm substances and of the reactivity of rheumatoid sera for human red cells sensitized with 3 different anti‐Rh sera or immune rabbit sera and for F. II Latex
Authors: Jacqueline F. , Podliachouk L. , Eyquem A. 
Published: February 2007

AbstractIn rheumatoid arthritis (R.A.) in addition to the rheumatoid factors detected by the Waaler‐Rose and latex F. II tests,Henceforth we will use instead of “rheumatoid factors detected by the Waaler‐Rose and latex F II tests,” the abbrevation “rheumatoid factor.”
anti‐Gm substances and agglutinins for human red cells sensitized with 3 different anti‐Rh sera appear, mainly in cases of severe disease of long duration. Usually, during the evolution of the disease, their titer does not parallel that of the rheumatoid factors; this fact is in favor of the individuality of the anti‐Gm substances.
Effect of orally administered D‐penicillamine on gold deposited in the rat kidney
Authors: Davidson Paul , Engleman Ephraim P. 
Published: February 2007

AbstractAlthough orally administered D‐penicillamine, a chelating agent, is known to enhance urinary excretion of gold in man, studies in experimental animals raised the possibility that renal deposition of gold might increase in the presence of the circulating gold‐penicillamine complex. To investigate this possibility, rats previously treated with a gold salt were given a diet containing the chelating agent for a 28‐day period. The renal content of gold was assayed at the end of the study period. The results showed that administration of D‐penicillamine significantly enhanced the removal of gold from the kidneys.
A clinical‐pathological study of aleutian mink disease; an experimental model for study of the connective‐tissue diseases
Authors: Thompson George R. , Aliferis Peter 
Published: February 2007

AbstractA chronic disease spontaneously occurring in mink is described. This disease is characterized by a genetic predisposition for mink carrying the Aleutian gene. It is manifested by renal, hepatic, and possibly arterial changes. There is marked hyperglobulinemia. The pathologic features of the disease are reviewed. Current studies have extended the knowledge regarding the hematologic and biochemical abnormalities. Comparison of the abnormalities of this disease to human connective‐tissue diseases is made.
Urinary excretion of pyridoxine and 4‐pyridoxic acid in rheumatoid arthritis
Authors: McKusick Anne B. , Sherwin Roger W. , Jones Lynn Grupenhoff , Hsu Jeng M. 
Published: February 2007

AbstractSeven patients with active rheumatoid arthritis excreted significantly less pyridoxine in the urine than controls when patient‐control pairs were fed identical constant diets while receiving no drugs. After a 10 mg. dose of pyridoxine hydrochloride, change in objectively measured stiffness appeared to be inversely related to change in urinary excretion of pyridoxine. The study does not necessarily show that giving rheumatoid arthritics pyridoxine is beneficial.
Urinary hydroxyproline levels in an aged population a study of non‐osteoporotic and osteoporotic patients
Authors: Moskowitz Roland W. , Klein Leroy , Katz David 
Published: February 2007

AbstractTotal urinary hydroxyproline in both a non‐osteoporotic and osteoporotic group of aged persons did not differ significantly from that in a young adult population, suggesting that collagen metabolism in the aged as reflected by urinary hydroxyproline does not differ markedly from that in younger persons. No direct correlation could be made between measurements of bone size and hydroxyproline excretion. Serum alkaline phosphatase and hydroxyproline excretion did not parallel within the normal range of values studied.
The detection of anti‐globulin factors utilizing pre‐coated latex particles
Authors: Singer Jacques M. , Plotz Charles M. , Goldberg Rosalie 
Published: February 2007

AbstractA modified serological procedure for the detection of anti‐gamma globulin factors has been developed. This test employs polystyrene latex particles with a diameter of 0.25 microns. The particles are coated with gamma globulin and the excess protein in solution is removed by repeated washing. A solution of these gamma globulin coated particles is stable for at least one year, and yields more reproducible titers than those originally described for the latex agglutination test.
Multiplicity of rheumatoid factor
Authors: Milgrom Felix , Tönder Olav 
Published: February 2007

AbstractThe reactions between rheumatoid factor and erythrocytes sensitized by antibodies of human, rabbit and guinea pig origin were studied using absorption, elution, dispersion, inhibition and mixed agglutination experiments. The results indicated that there are separate molecules of the rheumatoid factor combining with γ‐globulin of the three species.
The concentration of haptoglobin in synovial fluid of patients with rheumatoid arthritis
Authors: Niedermeier William , Cross Richard , Beetham William P. 
Published: February 2007

AbstractThe low concentrations of haptoglobin found in “normal” synovial fluid suggested that the synovial membrane normally possesses a mechanism for specifically excluding this glycoprotein from the joint space. In patients with rheumatoid arthritis this mechanism is apparently at least partially blocked as evidenced by the marked increase in haptoglobin concentration relative to the increase in concentration of albumin and total proteins in the synovial fluid.