bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alteration in physio-chemical properties and gene expression pattern of snapmelon (Cucumis melo var. momordica) genotypes against drought stress
Authors: Ansari Waquar Akhter , Krishna Ram , Yadav Punam Singh , Chaubey Tribhuvan , Behera Tusar Kanti , Bhat Kangila Venkataraman , Pandey Sudhakar 
Published: February 2024

AbstractLack of water at limiting levels results in drought stress, which may have an impact on the various stages of a crop's life cycle. Four different genotypes of snapmelon (Cucumis melo L. var. momordica) responded differently to 0, 7 and 21 d of simulated drought stress. Information was collected on a range of morpho-physiological, biochemical and molecular characteristics. Each genotype had longer roots, though BAM-VR-312 had the longest roots overall. As the severity of the drought grew, the net photosynthetic rate (Pn) and stomatal conductance (Gs) dropped. In BAM-VR-312, a smaller decline in relative water content (RWC) was recorded, despite the fact that drought stress caused a significant fall in RWC. BAM-VR-312 had smaller accumulations of electrolyte leakage, hydrogen peroxide, phenol and malondialdehyde, although proline content was greater. A decrease in photosynthetic pigments was noted, though BAM-VR-312 had the least reduction. Antioxidant enzyme activity increased in BAM-VR-312, as evidenced by records of ascorbate peroxidase, catalase, guaiacol peroxidase, glutathione reductase and superoxide dismutase. Similarly, expression level of their respective genes was recorded highest in BAM-VR-312. Overall, the study clearly identified distinct genotype based on morpho-physiological, biochemical and molecular properties under drought stress and revealed that the genotype BAM-VR-312 had more efficient drought tolerance mechanisms than the other genotypes under the drought stress condition.
How American Am I?
Authors: Ferguson Jauhara 
Published: February 2024

AbstractMuch sociological attention has focused on Black identity within the United States. Less attention, however, has been given to understanding how immigrant and native-born streams of U.S. Black Muslims articulate American identity. In this study I ask: how do second-generation Black American Muslims and indigenous Black American Muslims compare in the ways they narrate connections among race, American identity, and Islam? Using data from thirty-one in-depth interviews with Black Muslims living in Houston, TX, I find that racial double-consciousness complicates American identity for respondents. While indigenous Black American respondents critique racist U.S. histories and structural inequities, I argue that in certain spaces Muslim identity reinforces American identity. For second-generation respondents, however, American identity is reinforced through embracing immigrant status. This study extends Du Boisian double-consciousness by making a case for “layered double-consciousness.” I argue that layered double-consciousness better explains how Black Muslims perceive their racial, religious, and national identities across macro levels within the context of the United States and meso levels within the Muslim American community.
Formation and Dynamics of a Coherent Coastal Freshwater Influenced System
Authors: Barton Benjamin I. , De Dominicis Michela , O’Hara Murray Rory , Wolf Judith , Gallego Alejandro 
Published: February 2024

AbstractOn the Northwest European Shelf rivers provide freshwater to the coastal seas. This coastal freshwater can be misrepresented in ocean models without effective coastal resolution. This leaves an unanswered question; is freshwater retained around Scotland and what affects its variability? Here, we deploy and run an unstructured model with enhanced coastal resolution to simulate the Northwest European Shelf from 1993 to 2019, the Scottish Shelf Water‐Reanalysis Service (SSW‐RS) long‐time run. The unstructured nature of the model grid means it more accurately captures a “bubble” of Coastal Water than a 7 km structured grid model (the Atlantic Margin Model 7 km). Surface salinity in the SSW‐RS shows salinity fronts within 80 km of the coast around west and north Scotland that disintegrates east of Orkney. There are periods characterized by high coastal salinity when freshwater is more actively advected away from the coast. Empirical orthogonal function statistical analysis shows the first two modes in surface salinity account for 66% of the variance. The first mode correlates with North Atlantic Oscillation and the salinity driven velocity variability which change the salinity through advection and diffusion. The second mode correlates with Ekman transport variability where the north of Scotland acts as a wedge causing bipolar dynamics either side. Freshwater is trapped in the west, while saline water from the north reduces the freshwater pathway to the North Sea. This is important for salinity distribution, stratification in the North Sea, marine habitats and frontal transport.
How Strong/Weak Is Epidote Relative to Plagioclase?
Authors: Incel Sarah , Mohrbach Lisa Katharina , Renner Jörg 
Published: February 2024

AbstractIn natural lower crustal rocks, we observe that plagioclase breakdown is often partial as evidenced by the presence of epidote‐group minerals and the absence of the remaining reaction products for example, kyanite and quartz. Due to the lack of experimental data on epidote deformation, it is unclear if this partial reaction would affect the strength of the plagioclase‐rich lower continental crust. We experimentally investigated the relative strength of pure epidote and pure plagioclase aggregates at a confining pressure of 1 GPa, two different temperatures (550 and 650°C) and two different strain rates (5 × 10−5 and 5 × 10−6 s−1) using a Griggs apparatus. Furthermore, we investigated potential strength differences due to differences in grain size by deforming aggregates with grain‐size ranges of either ≈90–135 μm or <25 μm. Under identical conditions, epidote aggregates are either as strong as their plagioclase counterparts or moderately stronger, suggesting that the partial replacement of plagioclase by epidote‐group minerals would not have a permanent weakening effect on the strength of the lower continental crust.
Interplanetary Magnetic Field By Effects on the Strength and Latitude of Field‐Aligned Currents in Different Magnetic Local Time Sectors
Authors: Wang Hui , Sun Yu , Lühr Hermann 
Published: February 2024

AbstractIn this work, IMF By effects on field‐aligned currents (FACs) are examined in different local time sectors, seasons, and hemispheres. At dusk and 09–14 MLT, when the eastward polar electrojet (PEJ) prevails, the northern FACp (poleward side FACs) are stronger when IMF By < 0 than when IMF By > 0. Conversely, at dawn, 21–02 MLT, and 09–14 MLT with westward PEJ, the northern FACp are stronger with IMF By > 0 compared to IMF By < 0. The southern FACp shows a reversed relationship with IMF By direction. The dependence of FACe (equatorward side FACs) on IMF By is weaker, except for the midday FACe, which shows opposite variations with respect to IMF By when compared to FACp. Stronger IMF By effect is observed in local summer in most of local times. The northern FACs are located at higher latitude for IMF By > 0 than for IMF By < 0 in local times with eastward PEJ, while the opposite trend is observed in other local times and in the Southern Hemisphere. The hemispheric difference in the peak latitude of FACs demonstrates an inverse relationship with its intensity, with stronger FACs located at lower latitudes. Overall, the local time and hemispheric differences in FACs strength and latitude are discussed in the context of interhemispheric field‐aligned currents linked to IMF By.
Enhanced Late Spring Ozone in Southern China by Early Onset of the South China Sea Summer Monsoon
Authors: Zhang Xiaorui , Lu Xiao , Wang Fan , Zhou Wen , Wang Peng , Gao Meng 
Published: February 2024

AbstractThe onset of the South China Sea summer monsoon (SCSSM) has profound impacts on meteorological conditions over East Asia. However, whether the interannual variability in monsoon onset date impacts ozone (O3) pollution remains unclear. Here, we investigate the relationship between early onset of SCSSM and late spring O3 in southern China. Our results show notable differences in surface O3 concentrations before and after SCSSM onset during early onset events in southern China. The enhanced O3 of 11.1 μg m−3 is supported by increased air temperature and solar radiation of 1.1 K and 30.9 W m−2 and reduced relative humidity of −5.7%. Both observation and model simulations confirm that O3‐favorable meteorological conditions modulated by early SCSSM onset can be found in May. It increases the boundary layer height and biogenic emissions of volatile organic compounds, enhancing O3 by 10 μg m−3 over southern China. Chemical processes dominate such increases in O3 with enhanced chemical production of 0.27 Tg month−1. Descending motion in southern China vertically transports O3 to surface by 0.10 Tg month−1, whereas horizontal advection reduces O3 concentration by 0.12 Tg month−1. The meteorological responses to colder sea surface temperature (SST) in the central equatorial Pacific are pronounced, leading to higher O3 concentrations over the Yangtze River Delta, while warmer SST in the Philippine Sea contributes O3 over the Pearl River Delta and eastern China. This study highlights the importance of SCSSM onset with respect to O3 in southern China, with promising applications in management of air pollution and agriculture.
Fludarabine-treosulfan versus fludarabine-melphalan or busulfan-cyclophosphamide conditioning in older AML or MDS patients – A clinical trial to registry data comparison
Authors: Beelen Dietrich Wilhelm , Iacobelli Simona , Koster Linda , Eikema Dirk-Jan , van Biezen Anja , Stölzel Friedrich , Ciceri Fabio , Bethge Wolfgang , Dreger Peter , Wagner-Drouet Eva-Maria , Reményi Péter , Stelljes Matthias , Markiewicz Miroslaw , McLornan Donal P. , Yakoub-Agha Ibrahim , Mohty Mohamad 
Published: February 2024

AbstractA randomized study (acronym: MC-FludT.14/L Trial II) demonstrated that fludarabine plus treosulfan (30 g/m²) was an effective and well tolerated conditioning regimen for allogeneic hematopoietic cell transplantation (allo-HCT) in older patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). To further evaluate this regimen, all 252 study patients aged 50 to 70 years were compared with similar patients, who underwent allo-HCT after fludarabine/melphalan (140 mg/m²) (FluMel) or busulfan (12.8 mg/kg)/cyclophosphamide (120 mg/kg) (BuCy) regimens and whose data was provided by the European Society for Blood and Marrow Transplantation registry. In 1:1 propensity-score matched-paired analysis (PSA) of AML patients, there was no difference in 2-year-relapse-incidence after FluTreo compared with either FluMel (n = 110, p = 0.28) or BuCy (n = 78, p = 0.98). However, 2-year-non-relapse-mortality (NRM) was lower compared with FluMel (p = 0.019) and BuCy (p < 0.001). Consequently, 2-year-overall-survival (OS) after FluTreo was higher compared with FluMel (p = 0.04) and BuCy (p < 0.001). For MDS patients, no endpoint differences between FluTreo and FluMel (n = 30) were evident, whereas 2-year-OS after FluTreo was higher compared with BuCy (n = 25, p = 0.01) due to lower 2-year-NRM. Multivariate sensitivity analysis confirmed all significant results of PSA. Consequently, FluTreo (30 g/m²) seems to retain efficacy compared with FluMel and BuCy, but is better tolerated by older patients.
CAnceR IN PreGnancy (CARING) – a retrospective study of cancer diagnosed during pregnancy in the United Kingdom
Authors: Baxter M. A. , Denholm M. , Kingdon S. J. , Kathirgamakarthigeyan S. , Parikh S. , Shakir R. , Johnson R. , Martin H. , Walton M. , Yao W. , Swan A. , Samuelson C. , Ren X. , Cooper A. , Gray H-L , Clifton S. , Ball J. , Gullick G. , Anderson M. , Dodd L. , Hayhurst H. , Salama M. , Shotton R. , Britton F. , Christodoulou T. , Abdul-Hamid A. , Eichholz A. , Evans R. M. , Wallroth P. , Gibson F. , Poole K. , Rowe M. , Harris J. ,   National Oncology Trainees Collaborative for Healthcare Research (NOTCH)
Published: February 2024

Abstract
Background
The incidence of cancer diagnosed during pregnancy is increasing. Data relating to investigation and management, as well as maternal and foetal outcomes is lacking in a United Kingdom (UK) population.

Methods
In this retrospective study we report data from 119 patients diagnosed with cancer during pregnancy from 14 cancer centres in the UK across a five-year period (2016-2020).

Results
Median age at diagnosis was 33 years, with breast, skin and haematological the most common primary sites. The majority of cases were new diagnoses (109 patients, 91.6%). Most patients were treated with radical intent (96 patients, 80.7%), however, gastrointestinal cancers were associated with a high rate of palliative intent treatment (63.6%). Intervention was commenced during pregnancy in 68 (57.1%) patients; 44 (37%) had surgery and 31 (26.1%) received chemotherapy. Live births occurred in 98 (81.7%) of the cases, with 54 (55.1%) of these delivered by caesarean section. Maternal mortality during the study period was 20.2%.

Conclusions
This is the first pan-tumour report of diagnosis, management and outcomes of cancer diagnosed during pregnancy in the UK. Our findings demonstrate proof of concept that data collection is feasible and highlight the need for further research in this cohort of patients.
CaSSiDI: novel single-cell “Cluster Similarity Scoring and Distinction Index” reveals critical functions for PirB and context-dependent Cebpb repression
Authors: Nechanitzky Robert , Ramachandran Parameswaran , Nechanitzky Duygu , Li Wanda Y. , Wakeham Andrew C. , Haight Jillian , Saunders Mary E. , Epelman Slava , Mak Tak W. 
Published: February 2024

AbstractPirB is an inhibitory cell surface receptor particularly prominent on myeloid cells. PirB curtails the phenotypes of activated macrophages during inflammation or tumorigenesis, but its functions in macrophage homeostasis are obscure. To elucidate PirB-related functions in macrophages at steady-state, we generated and compared single-cell RNA-sequencing (scRNAseq) datasets obtained from myeloid cell subsets of wild type (WT) and PirB-deficient knockout (PirB KO) mice. To facilitate this analysis, we developed a novel approach to clustering parameter optimization called “Cluster Similarity Scoring and Distinction Index” (CaSSiDI). We demonstrate that CaSSiDI is an adaptable computational framework that facilitates tandem analysis of two scRNAseq datasets by optimizing clustering parameters. We further show that CaSSiDI offers more advantages than a standard Seurat analysis because it allows direct comparison of two or more independently clustered datasets, thereby alleviating the need for batch-correction while identifying the most similar and different clusters. Using CaSSiDI, we found that PirB is a novel regulator of Cebpb expression that controls the generation of Ly6Clo patrolling monocytes and the expansion properties of peritoneal macrophages. PirB’s effect on Cebpb is tissue-specific since it was not observed in splenic red pulp macrophages (RPMs). However, CaSSiDI revealed a segregation of the WT RPM population into a CD68loIrf8+ “neuronal-primed” subset and an CD68hiFtl1+ “iron-loaded” subset. Our results establish the utility of CaSSiDI for single-cell assay analyses and the determination of optimal clustering parameters. Our application of CaSSiDI in this study has revealed previously unknown roles for PirB in myeloid cell populations. In particular, we have discovered homeostatic functions for PirB that are related to Cebpb expression in distinct macrophage subsets.
DUSP4 modulates RIG-I- and STING-mediated IRF3-type I IFN response
Authors: Jiao Huipeng , James Sharmy J. , Png Chin Wen , Cui Chaoyu , Li Heng , Li Liang , Chia Wan Ni , Min Nyo , Li Weiyun , Claser Carla , Rénia Laurent , Wang Hongyan , Chen Mark I-Cheng , Chu Justin Jang Hann , Tan Kevin Shyong Wei , Deng Yinyue , Zhang Yongliang 
Published: February 2024

AbstractDetection of cytosolic nucleic acids by pattern recognition receptors, including STING and RIG-I, leads to the activation of multiple signalling pathways that culminate in the production of type I interferons (IFNs) which are vital for host survival during virus infection. In addition to protective immune modulatory functions, type I IFNs are also associated with autoimmune diseases. Hence, it is important to elucidate the mechanisms that govern their expression. In this study, we identified a critical regulatory function of the DUSP4 phosphatase in innate immune signalling. We found that DUSP4 regulates the activation of TBK1 and ERK1/2 in a signalling complex containing DUSP4, TBK1, ERK1/2 and IRF3 to regulate the production of type I IFNs. Mice deficient in DUSP4 were more resistant to infections by both RNA and DNA viruses but more susceptible to malaria parasites. Therefore, our study establishes DUSP4 as a regulator of nucleic acid sensor signalling and sheds light on an important facet of the type I IFN regulatory system.
Transcription of endogenous retroviruses in senescent cells contributes to the accumulation of double-stranded RNAs that trigger an anti-viral response that reinforces senescence
Authors: Di Giorgio Eros , Ranzino Liliana , Tolotto Vanessa , Dalla Emiliano , Burelli Matteo , Gualandi Nicolò , Brancolini Claudio 
Published: February 2024

AbstractAn important epigenetic switch marks the onset and maintenance of senescence. This allows transcription of the genetic programs that arrest the cell cycle and alter the microenvironment. Transcription of endogenous retroviruses (ERVs) is also a consequence of this epigenetic switch. In this manuscript, we have identified a group of ERVs that are epigenetically silenced in proliferating cells but are upregulated during replicative senescence or during various forms of oncogene-induced senescence, by RAS and Akt, or after HDAC4 depletion. In a HDAC4 model of senescence, removal of the repressive histone mark H3K27me3 is the plausible mechanism that allows the transcription of intergenic ERVs during senescence. We have shown that ERVs contribute to the accumulation of dsRNAs in senescence, which can initiate the antiviral response via the IFIH1-MAVS signaling pathway and thus contribute to the maintenance of senescence. This pathway, and MAVS in particular, plays an active role in shaping the microenvironment and maintaining growth arrest, two essential features of the senescence program.
The reverse quantum limit and its implications for unconventional quantum oscillations in YbB12
Authors: Mizzi Christopher A. , Kushwaha Satya K. , Rosa Priscila F. S. , Phelan W. Adam , Arellano David C. , Pressley Lucas A. , McQueen Tyrel M. , Chan Mun K. , Harrison Neil 
Published: February 2024

AbstractThe quantum limit in a Fermi liquid, realized when a single Landau level is occupied in strong magnetic fields, gives rise to unconventional states, including the fractional quantum Hall effect and excitonic insulators. Stronger interactions in metals with nearly localizedf-electron degrees of freedom increase the likelihood of these unconventional states. However, access to the quantum limit is typically impeded by the tendency off-electrons to polarize in a strong magnetic field, consequently weakening the interactions. In this study, we propose that the quantum limit in such systems must be approached in reverse, starting from an insulating state at zero magnetic field. In this scenario, Landau levels fill in the reverse order compared to regular metals and are closely linked to a field-induced insulator-to-metal transition. We identify YbB12as a prime candidate for observing this effect and propose the presence of an excitonic insulator state near this transition.
Non-orthogonal optical multiplexing empowered by deep learning
Authors: Pan Tuqiang , Ye Jianwei , Liu Haotian , Zhang Fan , Xu Pengbai , Xu Ou , Xu Yi , Qin Yuwen 
Published: February 2024

AbstractOrthogonality among channels is a canonical basis for optical multiplexing featured with division multiplexing, which substantially reduce the complexity of signal post-processing in demultiplexing. However, it inevitably imposes an upper limit of capacity for multiplexing. Herein, we report on non-orthogonal optical multiplexing over a multimode fiber (MMF) leveraged by a deep neural network, termed speckle light field retrieval network (SLRnet), where it can learn the complicated mapping relation between multiple non-orthogonal input light field encoded with information and their corresponding single intensity output. As a proof-of-principle experimental demonstration, it is shown that the SLRnet can effectively solve the ill-posed problem of non-orthogonal optical multiplexing over an MMF, where multiple non-orthogonal input signals mediated by the same polarization, wavelength and spatial position can be explicitly retrieved utilizing a single-shot speckle output with fidelity as high as ~ 98%. Our results resemble an important step for harnessing non-orthogonal channels for high capacity optical multiplexing.
Effects of total sleep deprivation on performance in a manual spacecraft docking task
Authors: Piechowski Sarah , Kalkoffen Lennard J. , Benderoth Sibylle , Wolf Oliver T. , Rittweger Jörn , Aeschbach Daniel , Mühl Christian 
Published: February 2024

AbstractSleep deprivation and circadian rhythm disruptions are highly prevalent in shift workers, and also among astronauts. Resulting sleepiness can reduce cognitive performance, lead to catastrophic occupational events, and jeopardize space missions. We investigated whether 24 hours of total sleep deprivation would affect performance not only in thePsychomotor Vigilance Task(PVT), but also in a complex operational task, i.e. simulated manual spacecraft docking. Sixty-two healthy participants completed the manual docking simulation6dfand the PVT once after a night of total sleep deprivation and once after eight hours of scheduled sleep in a counterbalanced order. We assessed the impact of sleep deprivation on docking as well as PVT performance and investigated if sustained attention is an essential component of operational performance after sleep loss. The results showed that docking accuracy decreased significantly after sleep deprivation in comparison to the control condition, but only at difficult task levels. PVT performance deteriorated under sleep deprivation. Participants with larger impairments in PVT response speed after sleep deprivation also showed larger impairments in docking accuracy. In conclusion, sleep deprivation led to impaired6dfperformance, which was partly explained by impairments in sustained attention. Elevated motivation levels due to the novelty and attractiveness of the task may have helped participants to compensate for the effects of sleepiness at easier task levels. Continued testing of manual docking skills could be a useful tool both to detect sleep loss-related impairments and assess astronauts’ readiness for duty during long-duration missions.