bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comprehensive Analysis of Clinical Factors Affecting Drug Compliance in Schizophrenia
Authors: Shah Jeet Prakashkumar , Dsouza Jenifa Nora , Patil Nalini Mangesh 
Published: February 2025

Abstract

Background:
Noncompliance with prescribed antipsychotic medications significantly increases the risk of illness exacerbation and rehospitalization in patients with schizophrenia. One way to enhance drug compliance involves identifying key factors contributing to poor compliance and enabling the development of effective strategies to improve patient’s adherence to medications. Therefore, the aim of this study was to assess factors responsible for drug noncompliances and their associations with clinical variables.

Methodology:
This cross-sectional study was conducted at the Mahatma Gandhi Mission Medical College and Hospital, with approval from the Institutional Ethical Committee. A total of 47 subjects diagnosed with schizophrenia were included, and their sociodemographic information and consent forms were collected. Noncompliance was evaluated using a Rating of Medication Influences Scale. The severity of the disease was assessed using the Positive and Negative Syndrome Scale (PANSS).

Results:
A total of 47 patients participated, of whom 15 were male (31.91%) and 32 were female (68.09%). In our study, the factor that showed the strongest association with medication compliance was the perceived daily benefit. Significant associations were observed between drug noncompliance and the younger age group, unemployment, and a high positive PANSS score. The factors associated with antipsychotic drug noncompliance were denial of illness (χ2 = 35.6), stigma (χ2 = 12.97), substance abuse (χ2 = 15.55), and the belief that current medication is unnecessary (χ2 = 36.75).

Conclusion:
Patients with schizophrenia commonly demonstrate a high prevalence of medication nonadherence. Intervention strategies that prioritize patient education about their illness, prescribed medications, and potential side effects have shown promise in enhancing adherence to antipsychotic medication regimens.
How thyroid hormone disorder affect the expression of genes related to neurodegeneration in the hippocampus tissue of rats: An experimental study
Authors: Altunkaya Melek , Babur Ercan , Tufan Esra , Süer Cem , Dursun Nurcan 
Published: February 2025

ABSTRACT

Background:
Thyroid hormones (THs) have important effects on many organ systems, including the hippocampus, by modulating gene transcription. Therefore, deviations from the normal reference range of this hormone cause vital changes. However, it is not well understood how these hormones affect the expression of genes involved in the Akt1/Gsk3ß signaling pathway in hippocampus tissue. The study investigated the changes in gene expression in eight genes related to neurodegeneration in the hippocampus tissue of rats with TH disorder (Gsk3ß-mRNA, Cdk5-mRNA, Akt1-mRNA, Mapt-mRNA P35 [Anxa]-mRNA, Capn1-mRNA, Bace1-mRNA, and Psen2-mRNA).

Methods:
Twenty-two male rats were split into three groups as control, hypothyroidism, and hyperthyroidism. Propylthiouracil was given in drinking water for 21 days to induce hypothyroidism. L-thyroxine was administered for 21 days to induce hyperthyroidism. The levels of genes in the hippocampus were measured with the reverse transcription-polymerase chain reaction method.

Results:
While free thyroxine (fT4) levels in blood plasma were found to be lower in the hypothyroidism group than in the control group, fT4 levels in blood plasma were found to be higher in the hyperthyroidism group. The mRNA expression levels of Cdk5, Mapt, P35, Akt1, Psen2, and Bace1 genes evaluated in hippocampus tissue showed significant differences between the groups.

Conclusion:
THs are essential for the expression of certain genes, and these genes need to be expressed within a certain range for the body to function properly. Changes in hormone levels can partially change the expression of Akt1/Gsk3ß-mRNA, which is also associated with learning and memory.
Adopting a comprehensive approach to optimize medical education delivery in rural areas: A narrative review
Authors: Shrivastava Saurabh RamBihariLal , Bobhate Prateek Sudhakar , Petkar Prithvi Brahmanand , Mishra Vaishnavi H. 
Published: February 2025

ABSTRACT
Medical education plays a pivotal role in ameliorating health-related outcomes by preparing health-care professionals with the desired knowledge, skills, and attitudes necessary to deliver effective patient-centered care. The purpose of the current review is to explore the role of medical education in rural areas, identify the potential challenges in the implementation, and propose suitable measures to overcome these challenges. The delivery of medical education in rural areas is expected to address the disparities in health-care delivery by serving people in underserved areas, thereby reducing the urban–rural divide. This is accomplished by ensuring timely access to medical services, resulting in the promotion of early diagnosis and better management of the disease. The process of delivery of medical education in rural settings has been associated with multiple challenges that must be systematically dealt with to improve the overall outcomes. In conclusion, promoting access to medical education in rural areas is a crucial step to establishing a robust and equitable health-care system that will aid in the attainment of universal health coverage. However, the need of the hour is to overcome the existing challenges to empower aspiring health-care professionals from rural backgrounds and also contribute to the overall health and well-being of underserved communities.
Peri-operative management of newly diagnosed rheumatoid arthritis for cesarean section: A case report
Authors: Edohen Samson Ehiorobo , Imarengiaye Celestine Aluya , Osaikhuwuomwan James , Imarengiaye Charles Osalumese 
Published: February 2025

ABSTRACT
We present a 28-year-old booked G1P0 at 35 weeks scheduled for cesarean section to highlight the challenges with the anesthetic management of rheumatoid arthritis (RA) in a recently diagnosed parturient. She presented with a 4-day history of insidious multiple joint pains with high-grade fever. The joint pain started from the shoulder and affected mouth opening and neck movement. Her past medical history revealed that she had been on fertility treatment for reproductive difficulties. An assessment of early-onset RA in a booked nulliparous was made by the rheumatologist. On preoperative assessment for elective cesarean section, she reported a low-pitch hoarseness of voice following the onset of the flitting joint pains. The physical examination revealed a young woman, distressed and febrile to touch (38.6°C). There was mild tachycardia (heart rate = 102), regular, and good volume. The systolic blood pressure was 139/82 mmHg with first and second heart sounds only. The abdomen was at a fundal height of about 38 weeks. The fetal heart sounds were heard and regular. The airway examination indicated adequate mouth opening (4 cm), limited neck movement, and Class 3 Mallampati view. Prehydration was done with 0.9% saline 1000 mL, and spinal anesthesia was induced through the L3/4 interspace with a 25G pencil-point spinal needle The spinal medications, hyperbaric bupivacaine 9 mg + fentanyl 15 μg, were instilled. The sensory level was determined to be at T4. A set of twins was delivered with Apgar scores as follows, twin 1 (8/1, 9/5) and twin 2 (8/1, 9/5) by the attending neonatologist. The third stage was managed with oxytocin 5 i.u. bolus and 35 units in 500 mL of 0.9% to run at 100 mL/h. She was discharged on the 4th day postpartum having made remarkable improvement with the joint pain and movement. The postnatal clinic visit revealed a healthy mother and babies.
Innovative Mind-Body Therapy for Enhancing Psycho-Physiological Stability in Patients Undergoing Upper Gastrointestinal Endoscopy: A Randomized Controlled Study
Authors: Mani Sundari , Ethiraj Theranirajan , Rajendran Shankar Shanmugam , Anandhi Duraikannu , Elangovan Venba , Devadoss Sudha , Ramalingam Deepika 
Published: February 2025

ABSTRACT

Background:
Upper gastrointestinal endoscopy (UGIE) is a crucial diagnostic and therapeutic procedure for various gastrointestinal conditions. However, it frequently induces significant anxiety and physiological disturbances in patients, which may affect procedural outcomes. Mind-body therapy has been proposed as a non-pharmacological intervention to mitigate these adverse effects.

Objective:
This study aimed to evaluate the effectiveness of mind-body therapy in improving psychological and physiological outcomes among patients undergoing UGIE.

Methods:
A randomized controlled trial was conducted at Rajiv Gandhi Government General Hospital, Chennai. Participants were assigned to either an experimental group receiving mind-body therapy or a control group receiving standard care. The mind-body therapy included video-assisted education, breathing exercises, and the Mendelsohn maneuver. Anxiety levels and physiological parameters were assessed pre- and post-intervention.

Results:
Patients in the experimental group exhibited significantly reduced anxiety levels and improved physiological stability compared to the control group. Statistical analysis revealed a meaningful association between mind-body therapy and enhanced patient comfort, with improvements in heart rate, blood pressure, and respiratory stability.

Conclusion:
Mind-body therapy, incorporating video-assisted education, breathing exercises, and the Mendelsohn maneuver, is an effective non-pharmacological intervention for reducing anxiety and enhancing physiological stability in patients undergoing UGIE. These findings support the integration of mind-body interventions into routine endoscopic care to improve patient outcomes. Future research should explore the long-term benefits and broader applicability of such interventions in endoscopic and other invasive procedures.
Sulfasalazine-double stranded ribonucleic acid nanoparticle for controlling Aedes aegypti mosquitoes
Authors: Subaraja Mamangam , Hillary V Edwin , Savarimuthu Ignacimuthu 
Published: February 2025

Background & objectives:

Aedes aegypti mosquitoes are vectors for dengue, Zika, Chikungunya, and yellow fever viruses, which threaten over half the world's population. Therefore, new techniques are needed to control vector mosquitoes. The present study aimed to control female A. aegypti by targeting 3β-hydroxysteroid dehydrogenase (3β-HSD) and ecdysone receptor (EcR), which could potentially disrupt egg development, using sulfasalazine (SSZ)-double-stranded RNA (ds-RNA) nanoparticles (NPs).

Methods:
The SSZ-dsRNA NPs are characterized by light microscopy, field emission scanning electron microscopy, atomic force microscopy, raman spectroscopy, and fourier-transform infrared spectroscopy analysis. Next, 40 pl of SSZ, dsRNA, and SSZ-dsRNA NPs individually were injected into eggs of Ae. aegypti. Finally, the temporal gene expression levels of 3β-HSD and EcR genes were assessed using quantitative reverse transcription polymerase chain reaction (qRT-PCR).

Results:
The mortality rate and sterility were significantly increased (p<0.05), and the percentage of fecundity and viable progeny (p<0.05) showed effective results when exposed to SSZ-dsRNA compared to control eggs. In addition, the Sf9 cell line also confirmed the downregulation of the m-RNA 3β-HSD and EcR successfully when exposed to SSZ-dsRNA.

Interpretation & conclusion:
The current study proves for the first time that SSZ-dsRNA NPs can be used broadly for 3β-HSD and ECR gene silencing in mosquitoes. The use of this NPs SSZ-dsRNA complex in mosquito eggs leads to reduced fecundity in Ae. aegypti. This method will open a new door for mosquito control, which can be explored and utilized with future comprehensive research for better results. This method is not only limited to the mosquito species like Ae. Aegypti, it can also be tried with different mosquitoes as well as other insect species that cause harm to humans as pests of crops or vectors of various diseases.
Pengaruh Kualitas Asset, Permodalan, Biaya Opersional Pendapatan Operasioanal Terhadap Profitabilitas Bank Umum Syariah
Authors: Santoso Arik Lutfi , Imamah Nurul , Fattah Abdul 
Published: February 2025

Penelitian ini membahas bagaimana pengaruh kualitas asset, permodalan, biaya operasioanal pendapatan operasional terhadap profitabilitas bank umum syariah. Data yang diperoleh dari Bank Indonesia dan OJK dengan menggunakan purposive sampling dimana berupa data cross seaction dengan jumlah sampel 66 data terdiri dari 11 Bank Umum Syariah dan 6 tahun (2013-2018). Variabel yang digunakan adalah Kualitas Asset, Permodalan, Biaya Operasioanal Pendapatan Operasioanal sebagai variabel bebas dan Profitabilitas sebagai variabel terikat. Dari hasil penelitian ini diketahui NPF dan BOPO berpengaruh signifikan negatif terhadap ROA dapat dilihat dari nilai coefficient regresi yang bernilai negatif. Variabel CAR menunjukan nilai signifikan sebesar 0,1903 yang nilainya lebih besar dari pada p-value 0,05. Nilai Signifikan ini menunjukan bahwa CAR tidak berpengaruh terhadap ROA. Sedangakan variabel yang memiliki pengaruh dominan terhadap variabel ROA adalah NPF 0,20071 dari seluruh besarnya pengaruh variabel bebas CAR dan BOPO.
Peran Bumdes Terhadap Pengembangan UKM Furniture di Kecamatan Krian Kabupaten Sidoarjo
Authors: Anwar Khoirul , Haryono Haryono , Fattah Abdul 
Published: February 2025

Usaha Kecil dan Menengah (UKM) merupakan salah satu bidang yang memberikan kontribusi yang signifikan dalam memacu pertumbuhan ekonomi Indonesia. Hal ini dikarenakan daya serap UKM terhadap tenaga kerja yang sangat besar dan dekat dengan rakyat kecil. Tetapi UKM yang ada di kecamatan krian masih menghadapi masalah antara lain masalah permodalan. Seiring perkembangan teknologi informasi dan komunikasi, maka ia juga telah dimanfaatkan untuk pemasaran dan penjualan produk-produk melalui dunia maya. Penjualan dan pemasaran produk melalui dunia maya mempunyai banyak keuntungan, yaitu cakupan yang luas, tidak mengenal ruang dan waktu, dapat dilakukan kapan saja dan dimana saja. Oleh karena itu BUMDES membantu mengembangkan UKM yang ada di kecamatan krian.
Human Capital and Business Success: Perspectives from Emerging Business Professionals
Authors: Ortiz Arjay F. , Ortega Sergiris A. , Santos Angelo R. 
Published: February 2025

Objectives: This study examines the perceptions of business students from Nueva Ecija regarding the role of human capital in achieving business success. Specifically, it investigates the contributions of human capital to productivity, innovation, sustainable growth, and resilience in alignment with Sustainable Development Goal (SDG) 8, which focuses on promoting inclusive and sustainable economic growth, employment, and decent work.

Theoretical Framework: Grounded in Human Capital Theory, the study highlights how education, skills, and experience influence organizational outcomes.

Method: A quantitative descriptive research design was employed, utilizing a structured survey questionnaire with Likert scale responses distributed to 120 business students selected through convenience sampling. Data were analyzed using descriptive statistics, including frequencies, percentages, and means.

Results and Discussion: The findings reveal a strong consensus among respondents on the critical importance of human capital in organizational success. Specifically, 85% of students agreed that human capital significantly drives productivity, innovation, and financial performance. Students also recognized its role in entrepreneurial success, particularly for minority entrepreneurs, and in enhancing business resilience. These results align with existing research emphasizing the strategic value of continuous learning and development.

Research Implications: The study advocates for educational institutions to integrate curricula emphasizing human capital development and for businesses to adopt management strategies that prioritize workforce capabilities as a key driver of sustainable success.

Originality/Value: This research provides unique insights into the perspectives of emerging business professionals, highlighting their preparedness to align their future practices with SDG 8 and contribute to sustainable economic growth.
Psychological Capital as a Moderator of Employee Engagement and Creativity on Personnel Performance in East Kalimantan Hospitals for SDGs
Authors: Mualimin Jaya , Setyadi Djoko , Zainurossalamia Saida , Kuleh Yohanes , Aziz Abdul 
Published: February 2025

Objective: This study aims to analyze the impact of employee engagement on organizational performance in government hospitals, focusing on the moderating role of Psychological Capital – comprising resilience, optimism, self-efficacy, and hope – strengthening this relationship.

Theoretical Framework: Grounded in theories of employee engagement and Positive Organizational Behavior, this research positions Psychological Capital as a crucial construct that enhances an individual’s motivational and cognitive resources.

Method: Using a quantitative research design, data were collected through structured surveys from hospital employees across various administrative and clinical departments. Statistical analyses revealed that employee engagement has a significant positive impact on performance, with Psychological Capital playing a moderating role that strengthens this relationship.

Results and Discussion: These findings highlight the importance of a supportive work environment, especially in government hospitals. High levels of resilience, optimism, self-efficacy, and hope were shown to reinforce the link between engagement and performance.

Research Implications: The implications of this study support the achievement of the Sustainable Development Goals (SDGs), particularly Good Health and Well-being (Goal 3) and Decent Work and Economic Growth (Goal 8). Strategies such as organizational learning programs, alignment with the hospital's vision and mission, and active employee participation can enhance engagement and Psychological Capital, thereby improving service quality and operational efficiency.

Originality/Value: These results provide a new framework for hospital management to design interventions aimed at improving motivation, well-being, and organizational success in the face of administrative challenges and resource constraints.
Consistency of Thailand National Energy Plan and Strategic Policy for Energy Management Toward SDG
Authors: Anontapant Piti , Kongsong Waranon , Pooworakulchai Chaiwat , Snongtaweeporn Teeradej , Harnpanich Boontham 
Published: February 2025

Objective: The objective of this study is to a) compare the National Energy Plan (NEP) and Energy Strategy in a consistent manner. b) consistency of National Policy with statistical information from government agencies with the policies and concepts of stakeholders involved in national energy in relation to SDGs

Theoretical Framework: This qualitative research is conducted gathering literature, including directives from the National Energy Plan (NEP) and its stakeholders along the stream line to the building manager, to study the consistency of the NEP with comparative results from national statistics.

Method: By We are conducting a specific interview with a sample group of corporate energy executives, including policymakers, architects, engineers, and facility managers, as well as vendors from each category of energy materials.

Results and Discussion: According to the NEP, according to the COP 26 conference, the government set the policy for the energy sector in line with the NEP, aiming to reduce electricity purchasing from fossils and increase the efficiency of machinery. The Building Energy Code, (BEC) and Subsidization are determined, and other campaigns are prioritized. and the RE incentives are taken to promote in terms of taxonomy.

Research Implications: As a result of the interviews, no agency mentioned R&D on renewable energy technology relevant to the education field; it emphasized the need to support investment in new technology research and development projects to increase efficiency and reduce investment costs and ROI. The discussion represented the recent policies are in line with the results of reducing energy consumption in the business sector, then the policies should be continually supported.
Effective Strategies for English Language Competence Development in English Philology Studies
Authors: Kholodniak Olena 
Published: February 2025

Objectives: This research explores effective strategies for the development of English language competence within the educational context. The study focuses on the integration of English language modules at different educational levels and the incorporation of discipline-specific courses to address specific linguistic needs.

Methods: The research investigates the impact of digitalization measures, such as online laboratories, exam preparation modules, and online courses, on language learning outcomes and student engagement. These strategies were analyzed to understand their effects on language competence and engagement.

Results: The findings demonstrate the positive effects of these strategies in facilitating progressive and comprehensive language skill development. The integration of both traditional and digital approaches has shown improvements in the overall learning experience.

Conclusion: This research contributes to the ongoing discourse on innovative approaches to English language instruction. It provides insights into designing effective language learning programs. The recommendations presented aim to help English Philology students improve their English language skills, enabling them to communicate proficiently, comprehend complex texts, and succeed in their academic and professional pursuits.
Ayurvedic Management of Drug Resistant Obsessive Compulsive Disorder
Authors: Vipin Sharika , Jithesh M  
Published: February 2025

Obsessive compulsive disorder (OCD) is a debilitating neuropsychiatric disorder with a lifetime prevalence of 2 to 3 percent. Selective serotonin reuptake inhibitors (SSRIs) and Clomipramine are the established pharmacologic first-line treatments for OCD, and Exposure Response Prevention (ERP) is recommended as the first-line behavioral intervention, with Cognitive Behavioral Therapy (CBT) as an alternative. About 40-60% of patients show no or just partial symptom improvement from drug treatment, and long-term management results in significant adverse effects. Drug-resistant OCD is defined as individuals who have persisting symptoms after being exposed to at least two trials (6 months) of SSRIs. Psychiatric illness is dealt with as one of the 8 specialties of Ayurveda named Bhutavidya. According to the presentation and severity of symptoms, OCD can be diagnosed as Unmada. According to the evolved dosha status and severity of the symptoms, the management can be done with sodhana, samana, and rasayana chikitsa. Studies suggest that the add-on effect of Yoga can also be beneficial in OCD. A 40-year-old female presented with recurrent, persistent thoughts about contamination followed by increased cleaning rituals such as excessive hand washing, increased time taken for bathing, and washing clothes. This condition was diagnosed as OCD, and she had been on SSRIs for more than 3 years, but no relief in symptoms was found. She underwent various treatments, and the total duration of intervention was 45 days. The Yale-Brown Obsessive Compulsive Disorder (Y-BOCS) score was 38 upon admission, which reduced to 19 after intervention.