bluuebunny/crossref_metadata_2025_split huggingface dataset:
Breathing across ages: a systematic review on challenges and components of transitional care for young people with asthma
Authors: Antonino Luna , Van Hoorenbeeck Kim , van Olmen Josefien , Vanharen Yaël , Janssens Natwarin , Verhulst Stijn , Goossens Eva 
Published: February 2024

IntroductionAsthma is a chronic condition that affects millions of adolescents and young adults (AYA) worldwide. The transition from pediatric to adult care presents unique challenges for this population, affecting their self-management, quality of life and overall health outcomes. This systematic review aims to consolidate the available evidence on challenges encountered by AYA with asthma during the transition period from child to AYA and on the key elements of transitional care for AYAs with asthma including the outcomes achieved, ultimately enhancing outcomes.MethodologyA systematic literature search was performed in PubMed, Embase, Medline, Scopus, and Web of Science from their inception to October 2, 2023, to provide an overview of currently available literature. Primary quantitative and qualitative studies, published in peer-reviewed journals that focused on AYA with a confirmed diagnosis of asthma were considered if they focused on challenges encountered by AYA with asthma during the transition process and/or components of transitional care and their outcomes assessed.ResultsA total of 855 studies were initially identified and 6 articles were included in this systematic literature review. Several challenges experienced by AYA with asthma were identified including maintaining medication adherence, the need to take responsibility and being involved, understanding their condition and its severity, feeling left out of the care system, and experiencing a lack of engagement. The identified transitional care components included a standardized form for medical data transmission, a joint consultation and to offer several longer consultations.ConclusionSeveral international guidelines for asthma care recommend implementing transition programs in the care for AYA with asthma. Such transition programs should include a comprehensive and individualized approach addressing several challenges faced, to ensure optimal outcomes post-transition. However, to date, data on effective components of transitional care facilitating good outcomes were found to be limited. This systematic review underscores the need for larger studies evaluating the effect of the components of transition programs.
Liver-boosting potential: chicory compound-mediated silver nanoparticles for hepatoprotection—biochemical and histopathological insights
Authors: Siddiqa Ayesha , Qureshi Rahmatullah , Raja Naveed Iqbal , Khan Imtiaz Ahmed , Ahmad Muhammad Zishan , Rafique Shaista , Ali Amir , Ahmad Ajaz , Kaushik Prashant 
Published: February 2024

Background: Liver disease is a serious health concern in today’s world, posing a challenge to both healthcare providers and pharmaceutical companies. Most synthetic drugs and chemicals cause liver damage accounting for approximately 10% of acute hepatitis and 50% of acute liver failure.Purpose: The present study aimed to evaluate the hepato-protective activity of an extract of chicory formulation assisted by silver nanoparticles against carbon tetra chloride (CCl4)-induced hepatic damage in rat’s liver.Methods: Rats of the Wistar strain (Rattus norvegicus) were used to test the in vivo hepato-protective efficacy at various doses. Rats were randomly divided into nine groups, each containing six rats. The groups were as follows: first group (control), second group (CCl4), third group, silymarin (20 mg/kg of body weight), fourth group (CCl4+chicory) (1.75 mg/kg of b. wt), fifth group (CCl4 + chicory at the dose of 2.35 mg/kg), sixth group (CCl4 + chicory of 3.25 mg/kg), seventh group (CCl4 +AgNPs 1.75 mg/kg of b. wt.), eighth group (CCl4 + AgNPs 2.35 mg/kg of body weight), and ninth group (CCl4 + AgNPs 3.25 mg/kg of b. wt.). Blood samples were taken 24 h after the last administration (i.e., 30th day). The blood samples were analyzed for different serum enzymes such as ALP (alkaline phosphatase), ALT (alanine transaminase), bilirubin (Blr), triglyceride, and cholesterol. Histology liver sections were performed.Results: Treatment with AgNPs and chicory extract showed significant hepato-protective activity in a dose-dependent manner. In three doses, the chicory extract at a rate of 3.25 mg/kg of body weight significantly reduced elevated levels of biochemical markers in comparison to CCl4-intoxicated rats. Histology of the liver sections from CCl4-treated rats revealed inflammation of hepatocytes, necrosis, cytoplasmic degeneration, vacuolization, and a deformed central vein. The chicory formulation extract exhibited a remarkable recovery percentage in the liver architecture that was higher than the drug (i.e., silymarin). While treatment with AgNPs also repaired the degenerative changes and restored the normal form of the liver, chicory formulation extract possessed more hepato-protective potential as compared to AgNPs by regulating biochemical and histo-pathological parameters.Conclusion: This study can be used as confirmation of the hepato-protective potential of chicory compounds for possible use in the development programs of drugs to treat liver diseases.
Patterns of C-reactive protein trends during clozapine titration and the onset of clozapine-induced inflammation: a case series of weekly and daily C-reactive protein monitoring
Authors: Kikuchi Yuki , Tanifuji Hiroaki , Ueno Sota , Onuma Yoshifumi , Goto Masatomo , Ishihara Masato , Toraiwa Takeshi , Komatsu Hiroshi , Tomita Hiroaki 
Published: February 2024

BackgroundInternational guidelines for clozapine titration recommend measuring C-reactive protein (CRP) weekly for 4 weeks after clozapine initiation to prevent fatal inflammatory adverse events, including myocarditis. However, limited evidence exists regarding whether weekly CRP monitoring can prevent clozapine-induced inflammation.AimsWe examined the relationship between CRP trends and the development of clozapine-induced inflammation. We also explored the usefulness and limitations of CRP monitoring during clozapine titration.MethodThis study presents 17 and 4 cases of weekly and daily CRP monitoring during clozapine initiation, respectively.ResultsAmong 17 patients with weekly CRP measurements, 7 had fever. Elevated CRP levels were detected before the onset of fever in two of the seven patients. Of the five remaining patients, the CRP levels on a previous test had been low; however, the fever developed suddenly. Of the 10 patients with no fever under weekly CRP monitoring, three had elevated CRP levels &gt;3.0 mg/dL. Refraining from increasing the clozapine dose may have prevented fever in these patients. Among four patients with daily CRP measurements, two became febrile. In both cases, CRP levels increased almost simultaneously with the onset of fever.ConclusionWeekly and daily CRP monitoring during clozapine titration is valuable for preventing clozapine-induced inflammation, assessing its severity, and guiding clozapine dose adjustments. Weekly CRP monitoring may not adequately predict clozapine-induced inflammation in some cases. Consequently, clinicians should be aware of the sudden onset of clozapine-induced inflammation, even if CRP levels are low. Daily CRP monitoring is better for detecting clozapine-induced inflammation.
Left atrial diastasis strain slope is a marker of hemodynamic recovery in post-ST elevation myocardial infarction: the Laser Atherectomy for STemi, Pci Analysis with Scintigraphy Study (LAST-PASS)
Authors: Kato Yoko , Lee Wei Hao , Natsumeda Makoto , Ambale-Venkatesh Bharath , Takagi Kensuke , Ikari Yuji , Lima Joao A. C. 
Published: February 2024

BackgroundLeft atrial (LA) mechanics are strongly linked with left ventricular (LV) filling. The LA diastasis strain slope (LADSS), which spans between the passive and active LA emptying phases, may be a key indicator of the LA–LV interplay during diastole.AimThis study aimed to investigate the LA–LV interdependencies in post-ST elevation myocardial infarction (STEMI), with particular focus on the LADSS.Materials and methodsPatients with post-anterior STEMI who received primary percutaneous coronary intervention underwent contrast cardiac magnetic resonance imaging (MRI) during acute (5–9 days post-STEMI) and chronic (at 6 months) phases. The LADSS was categorized into three groups: Groups 1, 2, and 3 representing positive, flat, and negative slopes, respectively. Cross-sectional correlates of LADSS Group 2 or 3 compared to Group 1 were identified, adjusting for demographics, LA indices, and with or without LV indices. The associations of acute phase LADSS with the recovery of LV ejection fraction (LVEF) and scar amount were investigated.ResultsSixty-six acute phase (86.4% male, 63.1 ± 11.8 years) and 59 chronic phase cardiac MRI images were investigated. The distribution across LADSS Groups 1, 2, and 3 in the acute phase was 24.2%, 28.9%, and 47.0%, respectively, whereas in the chronic phase, it was 33.9%, 22.0%, and 44.1%, respectively. LADSS Group 3 demonstrated a higher heart rate than Group 1 in the acute phase (61.9 ± 8.7 vs. 73.5 ± 11.9 bpm, p &lt; 0.01); lower LVEF (48.7 ± 8.6 vs. 41.8 ± 9.9%, p = 0.041) and weaker LA passive strain rate (SR) (−1.1 ± 0.4 vs. −0.7 [−1.2 to −0.6] s−1, p = 0.037) in the chronic phase. Chronic phase Group 3 exhibited weaker LA passive SR [relative risk ratio (RRR) = 8.8, p = 0.012] than Group 1 after adjusting for demographics and LA indices; lower LVEF (RRR = 0.85, p &lt; 0.01), higher heart rate (RRR = 1.1, p = 0.070), and less likelihood of being male (RRR = 0.08, p = 0.058) after full adjustment. Acute phase LADSS Groups 2 and 3 predicted poor recovery of LVEF when adjusted for demographics and LA indices; LADSS Group 2 remained a predictor in the fully adjusted model (β = −5.8, p = 0.013).ConclusionThe LADSS serves both as a marker of current LV hemodynamics and its recovery in post-anterior STEMI. The LADSS is an important index of LA–LV interdependency during diastole.Clinical Trial Registrationhttps://clinicaltrials.gov/, identifier NCT03950310.
Towards co-design of rehabilitation technologies: a collaborative approach to prioritize usability issues
Authors: Clanchy K. , Mitchell J. , Mulholland K. , Jurd E. , Kendall E. , Lloyd D. G. , Palipana D. , Pizzolato C. , Shirota C. 
Published: February 2024

IntroductionEarly stakeholder engagement is critical to the successful development and translation of rehabilitation technologies, a pivotal step of which is usability testing with intended end-users. To this end, several methods employ end-user feedback to identify usability and implementation issues. However, the process of prioritizing identified issues seldom leverages the knowledge and expertise of the range of stakeholders who will ultimately affect the demand and supply of a device. This paper describes a novel method to prioritize end-user feedback using transdisciplinary stakeholder consultation and address it in subsequent product development. The proposed approach was demonstrated using a case study relating to the development of a novel technology for neural recovery after spinal cord injury.MethodFeedback from five individuals with chronic spinal cord injury was collected during two-hour usability evaluation sessions with a fully functional high-fidelity system prototype. A think-aloud and semi-structured interview protocol was used with each participant to identify usability and acceptability issues relating to the system in a 3-phase approach. Phase 1 involved extracting usability issues from think-aloud and semi-structured interview data. Phase 2 involved rating the usability issues based on their significance, technical feasibility, and implementation priority by relevant internal and external stakeholders. Finally, Phase 3 involved aggregating the usability issues according to design and implementation elements to facilitate solution generation, and these solutions were then raised as action tasks for future design iterations.ResultsSixty usability issues representing nine facets of usability were rated. Eighty percent of issues were rated to be of moderate to high significance, 83% were rated as being feasible to address, and 75% were rated as addressable using existing project resources. Fifty percent of the issues were rated to be a high priority for implementation. Evaluation of the grouped issues identified 21 tasks which were mapped to the product roadmap for integration into future design iterations.DiscussionThis paper presents a method for meaningful transdisciplinary stakeholder engagement in rehabilitation technology development that can extended to other projects. Alongside a worked example, we offer practical considerations for others seeking to co-develop rehabilitation technologies.
Citrus Aphids in Algarve Region (Portugal): Species, Hosts, and Biological Control
Authors: Paiva Paulo Eduardo Branco , Neto Luís Mascarenhas , Marques Natália Tomás , Duarte Beatriz Zarcos , Duarte Amílcar Marreiros 
Published: February 2024

Aphids affect citrus by causing leaf deformations and reducing fruit production. Additionally, aphids are a great concern due to their ability to transmit Citrus tristeza virus (CTV), the cause of tristeza, one of the main citrus diseases. In the last four years, citrus orchards in the south of Portugal (Algarve region) were sampled for aphid species identification and counting. Aphis spiraecola was the most abundant species, representing more than 80% of all identified aphids, and the damage (leaf deformation) it causes was directly proportional to its density. A. gossypii was the second most common species, followed by A. aurantii and Macrosiphum euphorbiae. The number of aphids in nymph stages was predominant over the adult stages (both wingless and winged) in all species. A. citricidus, the most efficient CTV vector, was not detected. The largest populations of A. spiraecola were observed in lemon and orange trees during spring (>100 individuals per shoot), with great damage observed in orange, lemon, and mandarin trees. A. gossypii was observed mainly in mandarin and tangor trees. There was a low activity of natural biological control agents, with the parasitism of A. spiraecola by Lysiphlebus spp. and Binodoxys spp. ranging from 0.3 to 1.5%. The numerical ratio ranged from 150 to 440 aphids per predator, and among these, syrphids were the most abundant, followed by lacewings and coccinellids (Scymnus).
Distributed MIMO Measurements for Integrated Communication and Sensing in an Industrial Environment
Authors: Nelson Christian , Li Xuhong , Fedorov Aleksei , Deutschmann Benjamin , Tufvesson Fredrik 
Published: February 2024

Many concepts for future generations of wireless communication systems use coherent processing of signals from many distributed antennas. The aim is to improve communication reliability, capacity, and energy efficiency and provide possibilities for new applications through integrated communication and sensing. The large bandwidths available in the higher bands have inspired much work regarding sensing in the millimeter-wave (mmWave) and sub-THz bands; however, the sub-6 GHz cellular bands will still be the main provider of wide cellular coverage due to the more favorable propagation conditions. In this paper, we present a measurement system and results of sub-6 GHz distributed multiple-input-multiple-output (MIMO) measurements performed in an industrial environment. From the measurements, we evaluated the diversity for both large-scale and small-scale fading and characterized the link reliability. We also analyzed the possibility of multistatic sensing and positioning of users in the environment, with the initial results showing a mean-square error below 20 cm on the estimated position. Further, the results clearly showed that new channel models are needed that are spatially consistent and deal with the nonstationary channel properties among the antennas.
An Improved Public Key Cryptographic Algorithm Based on Chebyshev Polynomials and RSA
Authors: Zhang Chunfu , Liang Yanchun , Tavares Adriano , Wang Lidong , Gomes Tiago , Pinto Sandro 
Published: February 2024

Due to its very desirable properties, Chebyshev polynomials are often used in the design of public key cryptographic systems. This paper discretizes the Chebyshev mapping, generalizes the properties of Chebyshev polynomials, and proposes an improved public key encryption algorithm based on Chebyshev chaotic mapping and RSA, i.e., CRPKC−Ki. This algorithm introduces alternative multiplication coefficients Ki, the selection of which is determined by the size of TrTdxmod N=TdTrxmod N, and the specific value selection rules are shared secrets among participants, overcoming the shortcomings of previous schemes. In the key generation and encryption/decryption stages, more complex intermediate processes are used to achieve higher algorithm complexity, making the algorithm more robust against ordinary attacks. The algorithm is also compared with other RSA-based algorithms to demonstrate its effectiveness in terms of performance and security.
Isolamento e identificação de agentes bacterianos causadores de doença periodontal em cães
Authors: Ribeiro Heigly Eduarda Silva , Macente Beatrice Ingrid , Da Cunha Juliana Egas Rodrigues , Bressan Beatriz Navas dos Santos , Mansano Cleber Fernando Menegasso , Frias Danila Fernanda Rodrigues 
Published: February 2024

A doença periodontal acomete grande parcela dos cães acima dos quatro anos de idade, sendo caracterizada por placas bacterianas que se formam na superfície dos dentes, calcificando progressivamente até a formação do cálculo dentário. Objetivou-se com o presente trabalho isolar e identificar os agentes microbianos associados aos casos de doença periodontal em cães. Foram selecionados 20 cães com o diagnóstico de doença periodontal graus E2 a E4. Destes foram colhidas amostras na mucosa gengival por meio da fricção de um swab no biofilme dental do canino superior. As amostras foram inoculadas nos meios de cultura TSA (Trypticase Soy Agar) suplementado com extrato de levedura (5mg/ml) e acrescido de sangue equino desfibrinado (5%) (TSAS); TSBV (Trypticase Soy Serum Bacitracin/Vancimicin), BBE (Ágar Bacteroides Bile Esculina); Ágar MacConkey e Ágar EMB (Eosin Methylene Blue Agar). Após o período de incubação, foram obtidas as culturas puras e pelas suas características bioquímico-fisiológicas convencionais. Os dados obtidos foram tabulados e submetidos à análise da variância e a comparação das médias pelo teste de Duncan (p≤5). Dentre os 137 agentes identificados nos cultivos, observou-se 48,2% para Gram-positivos e 51% Gram-negativos, com prevalências das bactérias dos filos Proteobacteria e Firmicutes. Dentre estes, o gênero/espécie com as mais altas frequências foram bactérias Gram-positivas Staphylococcus spp, com 16 (80%) de frequência e por 15 (75%) de Streptococcus α-hemolitico, seguidas pelas bactérias Gram-negativas, que apresentaram altas frequências com as bactérias E. coli (12 – 60%) e Pasteurella spp (11 – 55%). Com base nos achados, espera-se auxiliar na instituição correta do tratamento, assim como estabelecer medidas profiláticas, para a doença periodontal em cães.
Pengaruh Ekspor, Foreign Direct Invesment, dan Utang Luar Negeri terhadap Pertumbuhan Ekonomi di Indonesia
Authors: Budiman Agit , Herdianto Moh. Jajang , Resti Rai 
Published: February 2024

The purpose of this study is to see the extent to which the Indonesian government is successful in carrying out international market activities, namely in the form of export activities, foreign direct investment, and foreign debt in influencing Indonesia's economic growth climate as measured based on GDP. This study uses quantitative methods, which are methods used to statistically explain the relationship and influence of exports, foreign direct investment, and foreign debt on economic growth of Indonesia. The data analysis technique used in this study is multiple linear regression analysis with the OLS (ordinary least squares) method as an estimator. The sample used is time series data for 32 years, from 1990-2022 from data on GDP, exports, foreign direct investment, and foreign debt. The results of data processing using Eviews show that the variables of export, foreign direct investment, and foreign debt have a positive and significant effect on Indonesia's economic growth.Penelitian ini bertujuan untuk melihat sejauh mana pemerintah Indonesia berhasil dalam menjalankan kegiatan pasar internasional yakni berupa kegiatan ekspor, foreign direct investment, dan utang luar negeri dalam mempengaruhi iklim pertumbuhan ekonomi Indonesia yang diukur berdasarkan PDB. Studi ini menggunakan metode kuantitatif, yaitu metode yang digunakan untuk menjelaskan secara statistik hubungan dan pengaruh ekspor, foreign direct investment, dan utang luar negeri terhadap pertumbuhan ekonomi di Indonesia. Teknik analisis data yang digunakan dalam metode ini adalah analisis regresi linear berganda dengan metode OLS (ordinary least squares) sebagai estimator. Sampel yang digunakan adalah data time series selama 32 tahun yakni dari tahun 1990-2022 dari data PDB, ekspor, foreign direct investment, dan utang luar negeri. Hasil pengolahan data menggunakan Eviews menunjukkan bahwa baik variabel ekspor, foreign direct investment, maupun utang luar negeri memberikan efek yang positif dan signifikan terhadap pertumbuhan ekonomi Indonesia.
Bagaimana Harga, Promosi, dan Kepemilikan Kendaraan Memengaruhi Permintaan Ojek Online di Kalangan Mahasiswa? (Studi Kasus Mahasiswa Universitas Siliwangi)
Authors: Nugraha Alek Surya , Azhari Septian Cahya , Firmansyah Muhamad Ferdy , Nasution Fatimah Zahra 
Published: February 2024

This research aims to determine the influence of price, promotion, and vehicle ownership on the demand for online motorcycle taxi services, both individually and collectively. Students of Siliwangi University for the academic period 2021-2022 were the target of our survey in this study, with a total population of 14,150 students, and 100 students were selected as samples. This research utilized the SEM-PLS method. Data were collected through observation, questionnaires, and literature reviews. The results indicate that the individual effects of price and promotion are positive and significant on the demand for online motorcycle taxi services. This means that as prices become more affordable and promotions become more attractive, the demand for online motorcycle taxi services increases. On the other hand, vehicle ownership has a negative and significant impact on the demand for online motorcycle taxi services, suggesting that an increase in vehicle ownership may lead to a decrease in demand for such services. As a recommendation, companies are advised to offer more attractive promotional deals, adjust prices according to regional coverage, and consider the impact of increased vehicle ownership in adjusting their business models.Penelitian ini memiliki tujuan untuk mengetahui bagaimana pengaruh harga, promosi, dan kepemilikan kendaraan terhadap permintaan jasa ojek online baik secara parsial maupun bersama-sama. Mahasiswa universitas Siliwangi periode akademik 2021-2022 menjadi target survei kami dalam penelitian ini dengan total populasi 14.150 mahasiswa dan 100 mahasaiswa menjadi sampel. Penelitian ini menggunakan metode SEM-PLS. Data dikumpulkan melalui observasi, angket, dan review literatur. Hasil penelitian menunjukkan pengaruh harga dan promosi secara individual adalah positif dan signifikan terhadap permintaan layanan ojek online. Artinya, semakin terjangkau harga dan semakin menarik promosinya, permintaan terhadap layanan ojek online meningkat. Di sisi lain, kepemilikan memiliki pengaruh negatif dan signifikan terhadap permintaan layanan ojek online, menunjukkan bahwa peningkatan jumlah kepemilikan kendaraan dapat mengakibatkan penurunan permintaan terhadap layanan tersebut. Sebagai rekomendasi, perusahaan disarankan untuk menyajikan tawaran promosi yang lebih menarik, menyesuaikan harga dengan cakupan regional, dan mempertimbangkan dampak kepemilikan kendaraan yang meningkat dalam penyesuaian model bisnis mereka.