bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association Between Cervical Inflammatory Mediators and Prevalent Cervical Human Papillomavirus Infection
Authors: Olukomogbon Temitope , Akpobome Bernice , Omole Aderonke ,   ACCME Research Group, Adebamowo Clement A. , Adebamowo Sally N. 
Published: March 2024

PURPOSE Inflammatory mediators are important regulators of immune response and can modulate the inflammation caused by viral infections, including human papillomavirus (HPV). In this study, we evaluated the association between cervical immune mediators, including chemokines, cytokines, and growth factors with HPV infections. MATERIALS AND METHODS We used a nonmagnetic bead–based multiplex assay to determine 27 immune mediators in cervical secretions collected from 275 women in a prospective longitudinal cohort design. All the study participants were age 18 years or older, had a history of vaginal sexual intercourse, were not currently pregnant, and had no history of cervical disease or hysterectomy. RESULTS The mean (±standard deviation) age of the participants was 41 (±8) years, and about half (51% [141/275]) were HPV-positive, of whom 7% (10/141) had low-risk HPV (lrHPV), 61% (86/141) had high-risk HPV (hrHPV), and 32% (45/141) had both lrHPV and hrHPV infections. Higher concentrations of some immune mediators were associated with HPV infections, including eotaxin, interferon-gamma, interleukin (IL)-1β, IL-2, IL-4, IL-7, IL-8, IL-9, IL-10, IL-12p70, IL-13, IL-15, macrophage inflammatory protein (MIP)-1α, MIP-1β, regulated upon activation normal T-cell expressed and secreted (RANTES), and tumor necrosis factor (TNF)-α and any HPV; IL-2, IL-4, IL-5, IL-7, IL-10, IL-12p70, and IL-13 and lrHPV; and eotaxin, interferon, IL-1B, IL-4, IL-7, IL-8, IL-9, IL-10, IL-13, IL-15, MIP-1α, MIP-1β, RANTES, TNF-α concentrations, and hrHPV infections. Higher concentrations of granulocyte macrophage colony-stimulating factor, IL-1 receptor antagonist (IL-1Ra), and monocyte chemotactic protein-1 (MCP-1) were associated with reduced odds of any HPV, while IL-1Ra and MCP-1 were associated with reduced odds of hrHPV infections. CONCLUSION Several chemokines, cytokines, and growth factors are associated with group-specific HPV infections in this population of women. These important findings contribute to the understanding of the immune response to HPV, cytokine profiles and their potential implications for cervical pathogenesis, and can guide future research in this field.
Rituals of Survival in Single-Room Occupancy Hotels
Authors: Biswas Debarati , Wachter-Grene Kirin 
Published: March 2024

Abstract
This article works with a definition of care that encompasses expansive models of kinship and collective and communal life. Specifically, it explores representations of such interdependencies in the liminal space of the single-room occupancy hotel (SRO) through the literary and artistic creations of two understudied African American artists. Fiction writer Robert Deane Pharr and visual artist Frederick Weston created their work in SROs in New York City beginning in the 1960s, during a time of massive transformation of the city's built environment in the name of urban renewal. Their novels and artwork, respectively, provide some of the only uncovered (to date) literary and cultural representations of New York City's SROs. Pharr's and Weston's works memorialize rituals of survival that center care and interdependencies over and against competitive individualism and a climate of uncare. Further, both explicitly articulate this vision by working with conceptual and material waste. Trash is their literal and metaphoric medium. These artists relied upon what is seen as surplus value by the city. But as Pharr and Weston use it, trash offers a critique of negative assumptions about the lives of SRO residents. The pandemic has shocked us into awareness of our inescapable interdependencies. Therefore, it behooves us to revisit these understudied, early proponents of care—an ethics that today's mutual aid and other liberation movements often center. Pharr's and Weston's documentation and interpretation of care offer us ways to survive within our current environments in crisis without repeating the death-making logic and history of urban renewal.
Comparative characteristics of the effectiveness of surgical treatment of various forms of atrial fibrillation
Authors: Sobitniak L. , Karpenko Yu. , Hitalchuk O. , Goryachyi O. , Blikhar O. 
Published: March 2024

The article analyzes the results of reconstructive operations on valves and CABG with MAZE carried out over the past 7 years at the Regional Center for Cardiac Surgery in Odessa in patients with chronic, paroxysmal and persistent forms of AF.
The expediency of supplementing open heart surgery (CABG, reconstructive valve surgery) with MAZE surgery has been shown for all patients with paroxysmal, persistent and chronic forms of AF.
Evaluated the effectiveness of the appointment of antiarrhythmic and anticoagulant therapy in these groups of patients.
Haemophagocytic lymphohistiocytosis following the anti-PD-1 nivolumab in a patient with gastric cancer and ankylosing spondylitis
Authors: Long Clara , Al-Abdulmalek Abdulrahman , Lai Jonathan , Haegert David G. , Isnard Stephane , Cournoyer Denis , Routy Jean-Pierre 
Published: March 2024

Background: Autoimmune diseases are not contraindications for immune checkpoint inhibitors (ICI) therapy in patients with cancer. However, immune-related adverse events (irAEs) are frequently observed in patients receiving ICIs including dermatitis, thyroiditis, colitis, and pneumonitis. Thrombocytopenic purpura, aplasia, and haemophagocytic lymphohistiocytosis (HLH) are rarely observed during ICIs. Case description: We report the case of a male patient with pre-existing untreated HLA B27 and ankylosing spondylitis with gastric cancer and liver metastases. The 79-year-old man was treated with anti-HER2 trastuzumab and anti-PD-1 nivolumab. Seventeen days after the seventh cycle of treatment, he presented at the emergency department with acute fever, confusion, and hypotension. Laboratory results showed pancytopenia, and elevation of ferritin and triglyceride. No infections were detected. Although not seen in a bone marrow biopsy, clinical presentation, and absence of infection, together with an H-score of 263, indicated HLH. The patient was treated with dexamethasone for four days and discharged on a tapering dose of steroids. At the two-month follow-up, clinical presentation was normal and blood test almost normalised. At 8 months, no liver metastases were observed. Conclusions: In a patient with a pre-existing autoimmune condition, immunotherapy led to the development of HLH, which was controlled by glucocorticoid. Absence of the feature of haemophagocytosis in the bone marrow biopsy did not exclude the diagnosis, as HLH can occur in the spleen or in the liver. Glucocorticoid therapy did not prevent the anti-cancer effect of ICIs, and liver metastases disappeared 8 months post-HLH. This case warrants further research on the interplay between autoimmunity and ICI response, as well as ICI-induced irAEs.
Special educator in public kindergartens, schools and institutions - a new position of specialist in the Polish education system in the opinion of teachers
Authors: Sikorski Jacek , Majewicz Piotr 
Published: March 2024

Cel pracyCelem podjętych badań było przedstawienie roli nowego specjalisty w systemie edukacji ogólnodostępnej, czyli pedagoga specjalnego - w percepcji nauczycieli.Materiał i metodyDo zebrania materiału empirycznego posłużono się metodą sondażu diagnostycznego, w ramach którego zastosowano autorski kwestionariusz ankiety składający się z 20 pytań otwartych i zamkniętych. Badaniami objęto 127 nauczycieli przedszkoli, szkół podstawowych i ponadpodstawowych ogólnodostępnych, głównie z południa Polski. Dobór osób do badań był celowy, ale pomimo tego uzyskano rozkład zbliżony do struktury populacji.WynikiUzyskane wyniki badań wskazują, że zdecydowana większość badanych nauczycieli placówek ogólnodostępnych, bo aż 87% dostrzega nie tylko potrzebę, ale wręcz konieczność zatrudnienia pedagoga specjalnego. Powinien on pełnić rolę lidera, koordynatora w zespole specjalistów zatrudnionych w ogólnodostępnych placówkach edukacyjnych. Badani nauczyciele, jako główne zadania pedagoga specjalnego, wskazali prowadzenie zajęć terapeutycznych, współpracę z poradnią psychologiczno-pedagogiczną, dostosowanie procesu dydaktycznego do specjalnych potrzeb uczniów.WnioskiNauczyciele szkolnictwa ogólnodostępnego uważają utworzenie nowego stanowiska specjalisty-pedagoga specjalnego za konieczność w obecnej fazie rozwoju edukacji włączającej.
Tax optimisation in the tax risk management process. Tax-legal analysis and selected managerial issues
Authors: Skrzypek-Ahmed Sylwia , Zientarski Piotr , Paździor Anna , Choroszczak Jerzy , Barwiak Paweł 
Published: March 2024

ObjectivesThe aim of the article is to theoretically present ways of legally optimising the taxation of entrepreneurs' income, by using the appropriate construction of legal regulations and legal and organisational forms of business. The issues of tax risk in the context of tax management are also presented. The goal of management is to reduce economic risk and to protect against its consequences.Material and methodsResearch in the social sciences, is inspired by numerous and diverse needs. Therefore, we will reduce the existing needs to two main types, to which certain types of research correspond. The first is combined with needs of a theoretical or cognitive nature, that is, it includes all those needs that are associated with the development of a particular science. The second is combined with the various needs of practice.ResultsIncome taxes also have a negative impact on the assets (equity) of entrepreneurs. The reduction in wealth results from the burdening of entrepreneurs with both wealth taxes and corporate income tax in the case of capital companies and, in the case of partnerships, with personal income tax for distributions made to partners.ConclusionsBoth of these risks describe a potential reality, i.e. the possibility of coming into conflict with the tax authorities. Their realisation is random, with the so-called double randomness - both the timing of the event (conflict) and its depth, i.e. the consequences, are unknown. These effects are mainly financial (arrears incurred, financial sanctions, etc.), although loss of credibility, for example, may also be involved. Importantly, both risks are linked to uncertainty, but each with a different one. Speculative risk is linked to the uncertainty of whether an illegal act will come to light.
Social Assessment of Local Government Authorities in Poland
Authors: Maciejewska-Mieszkowska Katarzyna 
Published: March 2024

Cel pracyCelem artykułu jest wskazanie głównych nurtów w percepcji społecznej władz samorządowych w aspekcie ich partycypacji wyborczej w 2014 i 2018 r.Materiał i metodyAnaliza została przeprowadzona w oparciu o komunikaty z badań Centrum Badania Opinii Społecznej. W celu zweryfikowania postawionej hipotezy zastosowano następujące metody badawcze: porównawczą, opisową i analizę danych zastanych.WynikiPomimo, że dopiero w 2018 r. frekwencja w wyborach samorządowych w Polsce przekroczyła ponad 50%, istotny jest fakt, że w trakcie kolejnych kampanii następował powolny, ale sukcesywny wzrost partycypacji wyborczej w procesie głosowania. Na podstawie przedstawionych danych należy też stwierdzić, że nie tylko wzrosła liczba osób wskazujących na wysoką rangę wyborów samorządowych i pozytywnie oceniających działania władz, ale że ocena ta przekłada się na decyzje wyborcze takie jak udział w wyborach i to na kogo wyborcy zagłosują. Rozpoznawalność kandydatów i zadowolenie z dotychczasowej ich działalności jako władz samorządowych była swoistego rodzaju katalizatorem dla ponownego poparcia ich w wyborach.WnioskiSpołeczna percepcja władz samorządowych w ujęciu ogólnym jest pozytywna i wyraźnie wynika z rozpoznawalności, postrzegania i oceny władz gminnych: rady gminy/miasta i wójta (burmistrza, prezydenta miasta). Jednak występują deficyty w kwestii wiedzy na temat działalności i kompetencji władz samorządowych na poziomie powiatów i województwa. Pozytywnym czynnikiem dla rozwoju świadomego uczestnictwa w życiu społecznym i politycznym, a w konsekwencji dalszego rozwoju demokracji lokalnej byłoby zwiększenie zainteresowania inicjatywami i działaniami władz samorządowych wyższego szczebla, a także rozpoznawalności osoby marszałka województwa.
Two approaches for triple coexistence of G-PON, XGS-PON, and 50G-PON systems with extended reach and a class-D ODN
Authors: Saliou Fabienne , Simon Gaël , Le Huérou Stéphane , Vu-Brugier Guillaume , Cano Ivan , Nesset Derek , Hong Zou , Rosales Ricardo , Bideau Maël , Potet Jérémy , Gaillard Georges , Chevalier Dylan , Zandueta Joseph , Talli Giuseppe , Chanclou Philippe 
Published: March 2024

In a first system configuration, a dedicated 50G-PON module was incorporated into the OLT, seamlessly coexisting with commercial G-PON and XGS-PON. The coexistence of the three generations of PONs is done here without adding any loss (filter) in existing ODNs, the 50G-PON being inserted on a 2:2 splitter at the CO. Furthermore, the possibility to extend the reach and place the 50G-PON OLT in a remote CO is evaluated. The second system uses a MPM at the OLT that includes the three PON generations. To our knowledge, this is the first full G-PON, XG(S)-PON, 50G-PON system prototype that provides an optical budget of 29 dB, and we demonstrate the possibility of extending the budget to 35 dB using SOAs.
Rosiglitazone alleviates LPS-induced endometritis via suppression of TLR4-mediated NF-κB activation
Authors: Bao Hongchu , Cong Jianxiang , Qu Qinglan , He Shunzhi , Zhao Dongmei , Zhao Huishan , Yin Shuyuan , Ma Ding 
Published: March 2024

Objective
The aim of this study was to investigate the anti-inflammatory effect of Rosiglitazone (RGZ) on lipopolysaccharide (LPS) -induced Endometritis and explore its possible mechanism.

Methods
The preventive and therapeutic effects of RGZ on Endometritis were studied in vivo and in vitro. A total of 40 female C57BL/6 mice were randomly divided into the following 4 groups: RGZ+LPS, RGZ control, LPS and DMSO control. The mice uterine tissue sections were performed with HE and immunohistochemical staining. Human endometrial stromal cells (HESCs) were cultured, and different concentrations of LPS stimulation groups and RGZ and/or a TLR4 signaling inhibitor TAK-242 pretreatment +LPS groups were established to further elucidate the underlying mechanisms of this protective effect of RGZ.

Results
The HE results in mice showed that RGZ+LPS group had less tissue loss than LPS group. Immunohistochemical staining (IHC) results showed that the expression of TLR4 after RGZ treatment was significantly lower than that in LPS group. These findings suggested that RGZ effectively improves the pathological changes associated with LPS-induced endometritis by inhibiting TLR4. Reverse transcription-polymerase chain reaction and western blot analysis demonstrated that RGZ pretreatment suppresses the expression of Toll-like receptor 4 (TLR4) and its downstream activation of nuclear factor-κB (NF-κB). In vitro, RGZ inhibited LPS-stimulated expression of proinflammatory cytokines in a dose-dependent manner and also downregulated LPS induced toll-like receptor 4 (TLR4) expression and inhibited phosphorylation of LPS-induced nuclear transcription factor-kappa B (NF-κB) P65 protein.

Conclusions
These results suggest that RGZ may inhibit LPS-induced endometritis through the TLR4-mediated NF-κB pathway.
Prognostic difference between surgery and external radiation in patients with stage I liver cancer based on competitive risk model and conditional survival rate
Authors: Chen Rong , An Yanli , Xu Muhao 
Published: March 2024

PurposeThis study aimed to assess the difference in prognosis of patients with early-stage liver cancer after surgery or external radiation.MethodsBetween 2010 and 2015, 2155 patients with AJCC 7thstage I liver cancer were enrolled in the SEER database. Among these, 1972 patients had undergone surgery and 183 had undergone external beam radiation. The main research endpoints were overall survival (OS) and disease-specific survival (DSS). The competitive risk model was used to calculate the risk ratio of liver cancer-specific deaths when there was a competitive risk. Propensity Score Matching (PSM) method using a 1:1 ratio was used to match confounders such as sex, age, and treatment method. Conditional survival was dynamically assessed for patient survival after surgery or external radiation.ResultsMultivariate analysis of the competitive risk model showed that age, disease diagnosis time, grade, and treatment [surgery and external beam radiation therapy (EBRT)] were independent prognostic factors for patients with hepatocellular carcinoma. Surgery had a higher survival improvement rate than that of EBRT. As the survival of patients with liver cancer increased, the survival curve of surgery declined more slowly than that of radiotherapy patients and stabilized around 3 years after surgery. The survival curve of radiotherapy patients significantly dropped within 4 years and then stabilized.ConclusionSurgery was better than EBRT for patients with stage I liver cancer. Close follow-up was required for 3 years after surgery or 4 years after external radiation. This study can help clinicians make better informed clinical decisions.
Assessing SOFA score trajectories in sepsis using machine learning: A pragmatic approach to improve the accuracy of mortality prediction
Authors: Palmowski Lars , Nowak Hartmuth , Witowski Andrea , Koos Björn , Wolf Alexander , Weber Maike , Kleefisch Daniel , Unterberg Matthias , Haberl Helge , von Busch Alexander , Ertmer Christian , Zarbock Alexander , Bode Christian , Putensen Christian , Limper Ulrich , Wappler Frank , Köhler Thomas , Henzler Dietrich , Oswald Daniel , Ellger Björn , Ehrentraut Stefan F. , Bergmann Lars , Rump Katharina , Ziehe Dominik , Babel Nina , Sitek Barbara , Marcus Katrin , Frey Ulrich H. , Thoral Patrick J. , Adamzik Michael , Eisenacher Martin , Rahmel Tim ,   on behalf of the SepsisDataNet.NRW research group
Published: March 2024

Introduction
An increasing amount of longitudinal health data is available on critically ill septic patients in the age of digital medicine, including daily sequential organ failure assessment (SOFA) score measurements. Thus, the assessment in sepsis focuses increasingly on the evaluation of the individual disease’s trajectory. Machine learning (ML) algorithms may provide a promising approach here to improve the evaluation of daily SOFA score dynamics. We tested whether ML algorithms can outperform the conventional ΔSOFA score regarding the accuracy of 30-day mortality prediction.

Methods
We used the multicentric SepsisDataNet.NRW study cohort that prospectively enrolled 252 sepsis patients between 03/2018 and 09/2019 for training ML algorithms, i.e. support vector machine (SVM) with polynomial kernel and artificial neural network (aNN). We used the Amsterdam UMC database covering 1,790 sepsis patients for external and independent validation.

Results
Both SVM (AUC 0.84; 95% CI: 0.71–0.96) and aNN (AUC 0.82; 95% CI: 0.69–0.95) assessing the SOFA scores of the first seven days led to a more accurate prognosis of 30-day mortality compared to the ΔSOFA score between day 1 and 7 (AUC 0.73; 95% CI: 0.65–0.80; p = 0.02 and p = 0.05, respectively). These differences were even more prominent the shorter the time interval considered. Using the SOFA scores of day 1 to 3 SVM (AUC 0.82; 95% CI: 0.68 0.95) and aNN (AUC 0.80; 95% CI: 0.660.93) led to a more accurate prognosis of 30-day mortality compared to the ΔSOFA score (AUC 0.66; 95% CI: 0.58–0.74; p < 0.01 and p < 0.01, respectively). Strikingly, all these findings could be confirmed in the independent external validation cohort.

Conclusions
The ML-based algorithms using daily SOFA scores markedly improved the accuracy of mortality compared to the conventional ΔSOFA score. Therefore, this approach could provide a promising and automated approach to assess the individual disease trajectory in sepsis. These findings reflect the potential of incorporating ML algorithms as robust and generalizable support tools on intensive care units.
Diverging likelihood of colon and rectal cancer in Yogyakarta, Indonesia: A cross sectional study
Authors: Puspitaningtyas Herindita , Hutajulu Susanna Hilda , Fachiroh Jajah , Anggorowati Nungki , Sanjaya Guardian Yoki , Lazuardi Lutfan , Sripan Patumrat 
Published: March 2024

Objectives
Colon and rectal cancer are associated with different risk factors and prognostic. However, this discrepancy has not been widely explored in the local population. This study aimed to investigate the site-specific likelihood of colorectal cancer (CRC) incidence in the Yogyakarta province, Indonesia.

Methods
This cross-sectional study analyses 1,295 CRC cases diagnosed in 2008–2019 registered in the Yogyakarta population-based cancer registry (PBCR) database. Cases were grouped into colon and rectal cancer. Log-binomial regression was used to determine the relative risk of either colon or rectal cancer across different gender, age group, and rurality of residence. The age-specific rates were calculated by age group and temporal trend for each group were analyzed using joinpoint regression.

Results
Females displayed higher odds of colon cancer (relative risk/RR = 1.20, 95%CI = 1.02–1.41) and lower odds of rectal cancer (RR = 0.92, 95%CI = 0.85–0.99). Elevated odds of colon cancer were observed in younger age group, especially 30–39 (RR = 1.87, 95%CI = 1.10–3.19), while decreased odds of rectal cancer was apparent in age group 30–39 and 40–49 (RR = 0.75, 95%CI = 0.60–0.93 and RR = 0.82, 95%CI = 0.69–0.98, respectively). Living in urban or rural areas did not significantly influence the odds of either having colon (RR = 0.98, 95%CI = 0.82–1.17) or rectal cancer (RR = 1.01, 95%CI = 0.93–1.10). During 2008–2019, trends of colon cancer in age <50 increased by 8.15% annually while rectal cancer displayed a 9.71% increase annually prior to 2017, followed by a 17.23% decrease until 2019.

Conclusions
Yogyakarta population shows higher odds of young-onset colon cancer, especially between age 30–39 years old. Overall observation of trend shows increasing incidence in young-onset colon cancer, and non-significant decrease in rectal cancer.