bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pan-cancer and single-cell analysis of actin cytoskeleton genes related to disulfidptosis
Authors: Shen Li-ping , Jiang Han-tao 
Published: March 2024

Abstract
Disulfidptosis was recently reported to be caused by abnormal disulfide accumulation in cells with high SLC7A11 levels subjected to glucose starvation, suggesting that targeting disulfidptosis was a potential strategy for cancer treatment. We analyzed the relationships between gene expression and mutations and prognoses of patients. In addition, the correlation between gene expression and immune cell infiltration was explored. The potential regulatory mechanisms of these genes were assessed by investigating their related signaling pathways involved in cancer, their expression patterns, and their cellular localization. Most cancer types showed a negative correlation between the gene-set variation analysis (GSVA) scores and infiltration of B cells and neutrophils, and a positive correlation between GSVA scores and infiltration of natural killer T and induced regulatory T cells. Single-cell analysis revealed that ACTB, DSTN, and MYL6 were highly expressed in different bladder urothelial carcinoma subtypes, but MYH10 showed a low expression. Immunofluorescence staining showed that actin cytoskeleton proteins were mainly localized in the actin filaments and plasma membrane. Notably, IQGAP1 was localized in the cell junctions. In conclusion, this study provided an overview of disulfidptosis-related actin cytoskeleton genes in pan-cancer. These genes were associated with the survival of patients and might be involved in cancer-related pathways.
Overexpression of miR-532-5p restrains oxidative stress response of chondrocytes in nontraumatic osteonecrosis of the femoral head by inhibiting ABL1
Authors: Shang Peng , Liu Ying , Ren Jie , Liu Qingqing , Song Haobo , Jia Junqing , Liu Qiang 
Published: March 2024

Abstract
This study is to probe into the meaning of serum miR-532-5p in nontraumatic osteonecrosis of the femoral head (ONFH), and a molecular mechanism of miR-532-5p in the development of nontraumatic ONFH. This study enrolled 96 patients diagnosed with nontraumatic ONFH and 96 patients with femoral neck fracture. The levels of miR-532-5p, ABL1, MMP-3, MMP-13, and cleaved-caspase3 were determined. Radiographic progression was assessed by ARCO staging system. Visual analog scale (VAS) and Harris hip score (HHS) were employed for evaluation of the symptomatic severity of nontraumatic ONFH. Cell viability and apoptosis in chondrocytes isolated from clinical samples were investigated with CCK-8 and flow cytometry. The levels of lactic dehydrogenase (LDH), superoxide dismutase (SOD), and malondialdehyde (MDA), mitochondrial membrane potential (ΔΨm), and reactive oxygen species (ROS) were determined. miR-532-5p was downregulated in tissues and serum of patients with nontraumatic ONFH, negatively related with ARCO staging and VAS, and positively correlated with HHS. Cell apoptosis, LDH, MDA, and ROS strengthened, while cell viability, ΔΨm, and SOD reduced in chondrocytes of nontraumatic ONFH patients. ABL1 was upregulated in cartilage tissues from nontraumatic ONFH patients. miR-532-5p targeted ABL1, and overexpressed miR-532-5p alleviated nontraumatic ONFH-induced oxidative stress damage of chondrocytes by restraining ABL1. miR-532-5p ameliorated oxidative stress injury in nontraumatic ONFH by inhibiting ABL1.
A review on partial substitution of nanosilica in concrete
Authors: Xiaohan Zhang , Ahmad Jawad , Jebur Yasir Mohammed , Deifalla Ahmed Farouk 
Published: March 2024

Abstract
One of the most popular and widely used cementitious nanoparticle materials is nanosilica (NNS). Although several researchers discuss how NNS affects the characteristics of concrete, knowledge is dispersed, making it difficult for the reader to assess the precise advantages of NNS. Therefore, a detailed review is required for the substitution of NNS in concrete. The present reviews collect the recently updated information on NNS as concrete ingredients. First, a summary of the manufacturing, physical, and chemical characteristics of NNS is provided. Second, the characteristics of fresh concrete are examined, including its effect on setting time, flowability, air content, and fresh density. Third, strength properties such as compressive, tensile, and flexure capacity are discussed. Finally, microstructure analyses such as scanning electronic microscopy and X-ray diffraction are discussed. The results show that NNS enhanced the mechanical and durability of concrete due to the pozzolanic reaction and microfilling voids but decreased the slump flow. The optimum dose is important for maximum performance. The typical optimum dose of NNS varies from 1 to 3% by weight of cement. This article also suggests future research directions to improve the performance of NNS-based concrete.
Enantiomeric separation of four pairs of alkaloids by using a C18 column tandem polysaccharide-based chiral column
Authors: Si Xiaoxi , Tian Yu , Xu Shufang , Liu Chunbo , Li Zhenjie , Yang Ji , Guan Ying , Xie Yangzhou , Shi Xiaoqing , Xu Zhigang , Liu Zhihua 
Published: March 2024

Abstract
Alkaloid enantiomers have different physiological and pharmacological effects, and different chiral compositions have a large impact on cigarette sensory and use safety. Studying the effects of different configurations of alkaloid enantiomers on cigarette sensory is important for the development of tobacco products, but the chiral separation of alkaloid enantiomers has become the core problem. Here, the application of a C18 column coupled with a polysaccharide-based chiral column to separate and detect four pairs of alkaloid enantiomers in tobacco and cigarette smoke of different brands was investigated. Results showed that the tandem technology of the two columns enabled the baseline separation of four pairs of alkaloid enantiomers. The resolution of enantiomers of alkaloids in different tobacco samples differed in content and ratio, showing different chiral distribution characteristics. According to the different distribution characteristics of alkaloid enantiomers, tobacco samples of different brands can be distinguished and real cigarettes can be identified.
Co-simulation approach for computational aero-acoustic modeling: Investigating wind-induced noise within two-way radio microphone ports cavity
Authors: Hairudin Wan Masrurah , Mat Mohamed Nur Hidayat , Ooi Lu Ean , Ismail Norilmi Amilia 
Published: March 2024

Wind-induced noise (aeroacoustic) can cause problem with any outdoor microphone applications, notably impacting the performance of telecommunication mobile. One prominent source in two way radios is the microphone port cavity. In this article, the noise characteristics behaviour is studied at scale-up of microphone port cavity through computational aero-accoustics (CAA) numerical simulation and experimental test. This research aims to investigate the wind-induced noise (aeroacoustic) generated inside the microphone port cavity at various wind orientation angles (wind direction) and distance radii, r. A direct-hybrid co-simulation CAA method, utilizing the LES-WALE (Wall-Adapting Local Eddy-viscosity) and Ffowcs William-Hawking (FW-H) models, is employed to obtain the near-field noise source and far-field noise patterns inside a microphone port cavity. The simulations are conducted using the scFLOW2Actran software. Richardson extrapolation and Grid Convergence Index (GCI) are applied to evaluate the accuracy of the grid independency in numerical simulations.The findings reveal that the leading edge, centre and trailing edge are the primary noise sources and generations inside a microphone port. The study indicates that the noise level in the microphone port cavity is characterized by low frequency noise.The results indicates that at an observation of angles of 0° and distance radii of 0.2 m, the wind noise level is higher compared to other orientation angle and distance radii. This can be attributed to the proximity to the noise source at this location. The directivity pattern of noise propagation exhibits a typical dipole pattern observed at observation angles of 0° to 45°. Numerical results align well with the experimental results from the wind tunnel test, demonstrating the feasibility of the proposed approach for flow-acoustic coupling application. This research holds significant value for engineers as it provides a comprehensive understanding of the physical phenomena involved in microphone port design.
Usability Analysis of Digital-Based Agricultural Product Marketing Platform at Farmers Level in Region V, Bogor Regency
Authors: Budiastuti Evrina , Ritchi Hamzah , Deliana Yosini 
Published: March 2024

Purpose: This study examines the usability of a digital platform called Kiosagri.com. This study needs to carry out as one of the solutions to overcome the limited accessibility of agricultural product promotion through the use of a digital platform that is expected to have usability. Therefore, this study aims to analyze the usability of digital-based agricultural product marketing platforms at the farmer level in Region V of Bogor Regency.Methods: This research employed a mixed method with an explanatory sequential design. The intended audience for the census of respondents was farmers who had utilized the Kiosagri.com platform. Data analysis was done on 32 respondents during the quantitative phase using descriptive statistics. Ten respondents were chosen purposefully for descriptive qualitative analysis during the qualitative phase.Results: According to the results, the Kiosagri platform is very user-friendly. It is achieved as a result of several beneficial aspects connected to the benefits perceived by users, such as ease of use, suitability of design, and features offered by Kiosagri.Novelty: In this study, a different way to measure the usability of digital platforms for agricultural products marketing is applied, namely by using the explanatory sequential design by conducting usability testing using descriptive statistics through the use of questionnaires and explaining the results further using descriptive qualitative through in-depth interviews which both methods are suitable for testing user experience and usability in the agricultural sector. The results of this study will be useful for the government in implementing digital marketing of agricultural products.
Causes of hyperferritinemia: what has changed with the pandemic?
Authors: Kılıç Özlem , Tekgöz Emre , Çolak Seda , Çimen Güneş Ezgi , Kaya Mehmet Nur , Çınar Muhammet , Yılmaz Sedat 
Published: March 2024

Purpose: In this study, we aimed to analyze patients with ferritin levels of ≥ 1000 ng/mL based on diagnoses and the wards they received both before the COVID pandemic and during the pandemic periods.
Materials and Methods: This retrospective study evaluated the patients who applied to a tertiary hospital and had ferritin onset of the pandemic. The patients' demographic and clinical characteristics and ferritin levels were obtained from the hospital's medical records.
Results: There were 2022 patients, 635 (31.4%) female and 1387 (68.6%) male, with a median age of 62 (49-71) years. 554 patients (27.4%) before the pandemic, and 1468 patients (72.6%) during the pandemic had ferritin levels of ≥ 1000 ng/mL. Hyperferritinemia was detected more frequently in males during the pandemic (p
Adult primary glomerular diseases due to podocytopathies: a single center experience on patient characteristics, treatment and outcomes
Authors: Bulgur İsmail , Şen Sait , Sarsık Kumbaracı Banu , Seziş Meltem , Yılmaz Mümtaz , Aşçı Gülay 
Published: March 2024

Purpose: This study aims to evaluate the demographic, clinical, and pathologic characteristics and response to immunosuppressive therapy, particularly corticosteroids, in adult patients with primary focal segmental glomerulosclerosis (FSGS) and minimal change disease (MCD), which are classified as podocytopathies.
Materials and Methods: Between January 1998 and December 2014, this study included 44 patients (27 with primary FSGS and 17 with MCD) aged older than 18 years with a histopathologic diagnosis, symptoms of nephrotic syndrome, and a minimum follow-up of six months. Patients were divided into two groups according to the treatment they received and three groups according to their response to treatment. Patients diagnosed with primary FSGS and MCD were evaluated based on clinical, demographic, and laboratory findings, as well as response to treatment, and a comparison was conducted between the two groups.
Results: 59.1% of the patients were male with a mean age of 44.8±17.7 years. At the time of diagnosis, there were no statistically significant differences in clinical and demographic characteristics between MCD and primary FSGS patients. However, in patients with MCD, the mean creatinine clearance (118.0±46.7 ml/min) was higher and the rate of microscopic hematuria (11.8%) was lower at the time of diagnosis. There was an increased need for alternative immunosuppressive treatments besides corticosteroids in patients with primary FSGS to achieve partial or complete remission. At both the third and sixth-month follow-ups, MCD patients achieved a higher rate of complete remission (proteinuria
Surgical preference for aortic root and ascending aortic aneurysm in pediatric patients: single-center experience
Authors: Yılmaz Mustafa , Soran Türkcan Başak , Ecevit Ata Niyazi , Ece İbrahim , Atalay Atakan 
Published: March 2024

Purpose: Aortic root and ascending aortic aneurysms are rarely encountered in pediatric patients. Our aim in this study was to compare our surgical approach and results in this patient group with similar studies in the literature.
Materials and Methods: This study retrospective in design and its cohort consists of pediatric patients who were operated on due to the diagnosis of aortic root and/or ascending aortic aneurysm. The etiologies of the patients that caused the aneurysm were investigated preoperatively, and the severity of the disease in the aortic valve and ascending aorta and surgical indications were revealed with detailed imaging methods. Operative data was then retrieved and early postoperative morbidity and mortality, as well as post-discharge aortic valve functions were evaluated. The obtained data was compared with those of similar articles in the literature.
Results: A total of eight pediatric patients were operated on with the diagnosis of aortic root and ascending aortic aneurysm. The average age of the patients was eleven (±4.03) years. The underlying cause of three (37.5%) patients was Marfan syndrome, two (25%) had bicuspid aortic valve and one (12.5%) had Wiscott-Aldrich Syndrome, previously operated sinus valsalva aneurysm and operated truncus arteriosus. There was 3rd degree aortic valve insufficiency in six patients (75%). The average aortic annulus diameter, mean sinus of valsalva diameter and ascending aorta diameter of the patients were 26.7 mm (±5.3), 40.9 mm (±9.7) and 37.8 mm (±9.2), respectively. The David I procedure was performed in three (37.5%) patients, while the Bentall procedure or aortic valve and ascending aorta replacement was performed on the other five patients. Non-cardiac mortality was observed in one (12.5%) patient, whereas native and mechanical valve dysfunction was not observed in any patient after discharge.
Conclusion: Both valve-sparing surgical procedures and other replacement techniques can be used safely in pediatric patients with aortic root and ascending aortic aneurysms.
Protective effects of jervine purified from Veratrum album on paracetamol-induced liver toxicity in rats
Authors: Yiğit Serdar , Aydın Tuba , Bitiktaş Soner , Bingöl Seyit Ali , Yayla Muhammed , Duysak Lale , Yeşilyurt İsa , Kahraman Ali Alper 
Published: March 2024

Purpose: Since paracetamol toxicity is a very common type of poisoning, we planned to investigate whether Jervine has an effect on paracetamol toxicity by utilizing its anti-inflammatory effect.
Materials and Methods: In our study, 42 Sprague Dawley rats of 8 weeks of age were used. Seven groups were formed with 6 animals in each group. At the 24th hour of the study, all groups underwent laparotomy under anesthesia, and liver dissection was performed. Hematoxylin and Eosin (H&E) staining was performed to evaluate liver histopathology. SOD, CAT, GSH, and MDA levels were analyzed biochemically.
Results: Histopathological, while liver tissues were normal in the control group, we observed degeneration areas, inflammation, and hemorrhage in the paracetamol group. Jervine reduced the severity of paracetamol toxicity and prevented liver damage. Jervine significantly increased SOD levels. Paracetamol administration significantly decreased CAT levels. Paracetamol significantly decreased GSH levels compared to the control group.
Conclusion: Jervine reduced the adverse effects of paracetamol toxicity on liver tissue, such as degeneration, inflammation, and hemorrhage. Jervine increased antioxidant activity and reduced the harmful effects of NAPQI, the toxic metabolite of paracetamol, on liver tissue.
Prevalence and association of high-intensity lesions with degenerative processes in lumbar intervertebral discs
Authors: Soydan Zafer , Bayramoğlu Emru 
Published: March 2024

Purpose: This population-based cross-sectional study examined the prevalence of high-intensity zones (HIZ) in the lumbar spine and their relationship to age, gender, disc degeneration, disc displacement (bulging or herniation), and facet joint degeneration.
Materials and Methods: A retrospective analysis was conducted on MRI studies of 800 patients (4000 discs) who were admitted to the hospital with subacute-chronic low back pain (LBP) and presented with axial pain (musculogenic-discogenic-mechanic) at outpatient clinics. The frequency of speed was determined by considering a total of seven age categories in decades. Correlation analyses were performed between HIZ and other variables.
Results: The prevalence of HIZ was 30%, highest in the >70 years age group and lowest in the
The association between C-reactive protein to albumin ratio and infarct location in patients with ST-segment elevation myocardial infarction
Authors: Tanrıverdi Zülkif , Fedai Halil 
Published: March 2024

Purpose: Inflammation has a crucial role in the pathogenesis of ST segment elevation myocardial infarction (STEMI). Recently, the C-reactive protein to albumin ratio (CAR) has emerged as a novel parameter of systemic inflammation. Although studies have demonstrated the that anterior STEMI location is associated with a higher infarct size and worse prognosis, no study has investigated the CAR in relation to infarct location. We herein aimed to evaluate whether there is a difference regarding the CAR between patients with anterior and non-anterior STEMI location.
Materials and Methods: The study population comprised 273 consecutive STEMI patients who were divided into 2 groups based on the STEMI location, as the anterior STEMI group (n=114) and non-anterior STEMI group (n=159). Baseline characteristics were recorded, and the CAR was calculated for all patients.
Results: Both groups were similar in terms of the baseline clinical characteristics. However, syntax score (p
Smart Cities and Tourism: A Paradiplomatic Approach Between Jakarta and Galicia
Authors: Rafi Ferdilianto  , Bariq Akmal Malik  , Christopher David Evans  , Fira Najwah BSA  , Nadira Refiana  
Published: March 2024

This study investigates the role of paradiplomacy in fostering enhanced cooperation between Jakarta, Indonesia, and Galicia, Spain, focusing on smart city initiatives and tourism development. Sub-state actors such as city, NGO and MNC nowadays have the rights to participate in the national agenda. In this area, Jakarta and Galicia both are a good example, in which those cities have multiple similarities in achieving their national agenda. Jakarta is known as a capital city of Indonesia, who become the main area of national economy improvement. Also in the other hand, Jakarta applied a concept of smart city in order to maximize the potential of its own area. Jakarta has sucessfully applied the concept correctly, which it answered by the infrastructure sector Jakarta made MRT and LRT which one of the goals of the concept. Galicia is known as city who has huge potential in its tourism sector and, also the management of the sector is rather quite neat. this paper explores the potential for bilateral paradiplomatic engagement to promote economic and infrastructural development. The findings suggest that paradiplomacy not only serves as a vital instrument for urban development but also paves the way for sustainable and mutually beneficial international collaborations.
Clinico-pathological profile of breast cancer patients in a radiation therapy centre
Authors: Rahman M. Masudur , Shams Mohammad Jahan , Haque Mostafa Sanaul , Biswas Shourov 
Published: March 2024

Background: The aim of the study was to evaluate the clinico-pathological characteristics of patients with breast cancer at the Radiation Center of Bangabandhu Sheikh Mujib Medical University (BSMMU), a tertiary‑care cancer center in Dhaka, Bangladesh.
Methods: This descriptive study was conducted from March 2021 to February 2022 where patients receiving radiotherapy for breast cancer were included. Data were collected from face-to-face interviews with patients and from their investigation reports. Data regarding age, presenting symptoms, histological type, tumor size, involvement of regional nodes, hormonal receptor status, and human epidermal growth factor receptor 2 (HER2) amplification were recorded and then analyzed.
Results: The mean age of the patients was 52.53 years. Most of the patients (93%) were multiparous and 62.24% were postmenopausal. The most common symptom was breast lump (91.6%). Infiltrating ductal carcinoma and lobular carcinoma were seen in 136 (95.1%) and 7 (4.9%) cases respectively. The TNM stage distribution was stage I, 6 (4.2%); stage II, 52 (36.36%); stage III, 76 (53.15%); and stage IV, 9 (6.29%). Locally advanced breast cancer constituted 42.66% of the cases. Among the patients 90 (62.94%) patients were ER/PR positive and 42 (29.37%) patients were HER2 positive. Triple negative breast cancer (TNBC) constituted 25.17% (36) of the study population. All receptors were positive in 25 patients (17.48%).
Conclusions: Majority of our patients receiving breast radiotherapy at our center are middle aged and have advanced disease. TNBC and HER2 positive breast cancer are more common in our population.