bluuebunny/crossref_metadata_2025_split huggingface dataset:
Squamous cell carcinoma of the proximal bile duct — A case report
Authors: Aranha Gerard V. , Reyes Cesar V. , Greenlee H. B. , Field Timothy , Brosnan Joseph 
Published: February 2007

AbstractA 56‐year‐old white male with abdominal pain, vomiting, and jaundice was found on exploration to have squamous cell carcinoma of the hepatic ducts with metastasis to the liver. He was treated with palliative procedure consisting of dilation of tumor and placement of T‐tube past the lesion. After recovering from surgery, patient was begun on radiation therapy to the liver and hilum, but his postoperative course was of progressive liver failure. This first necessitated cessation of radiation therapy and finally ended with the death of the patient three months after diagnosis.
The relationship of dietary selenium and breast cancer
Authors: McConnell Kenneth P. , Jager Rama M. , Bland Kirby I. , Blotcky A. J. 
Published: February 2007

AbstractAn inverse relationship exists between dietary selenium (Se) concentration and the incidence of human breast cancer. The addition of Se to the diet has been shown to decrease the incidence of spontaneous murine mammary tumors. We compared the serum Se concentrations in breast cancer patients with those of women without breast cancer. Serum was collected from 35 women with breast cancer. Nineteen of these women had infiltrating ductal carcinoma and two had Paget disease of the nipple. Nine women had lymph nodal metastases at the time of mastectomy, four had definite evidence of metastatic disease when the blood samples were drawn, and the disease process of one patient was unclassified. Samples from 27 women known to be free of breast cancer were used as controls. The difference noted between the mean serum Se concentrations of breast cancer patients and controls were found to be significant.
Simultaneous combination radiotherapy and multidrug chemotherapy for stage III and stage IV squamous cell carcinoma of the head and neck
Authors: Smith Bert L. , Franz Jerry L. , Mira Joaquin G. , Gates George A. , Sapp J. , Cruz A. B. 
Published: February 2007

AbstractCombined simultaneous radiotherapy and multidrug chemotherapy have been utilized in an attempt to eradicate or shrink tumors of the head and neck area in advanced stages to allow subsequent surgical extirpation. Thirty‐six patients (1 stage II; 11 stage III; 24 stage IV; 1 unknown primary) were treated with simultaneous radiotherapy and fractionalized doses of bleomycin, adriamycin, and 5‐fluorouracil. Thirty of 36 patients completed the treatment schedule. Twenty‐nine of 30 (97%) had a 75% or greater response to treatment; 20/30 (66%) had 100% response; 9/30 (30%) had 75% response; and 1/30 had 50% response. Of the 30 patients completing the regimen, 19/30 (63%) are alive three to 27 months later, and 12 (40%) of these have no evidence of disease. Six patients died within four months of initiation of therapy, mostly from complications of their disease. This treatment regimen appears effective in the control of locoregional disease or to produce enough shrinkage of tumor to allow subsequent surgical extirpation.
Inhibitory effects of Candida albicans extracellular polysaccharides on mouse sarcoma 180
Authors: Saltarelli Cora G. , Paveljack Coppola C. 
Published: February 2007

AbstractExtracellular glycoprotein produced by Candida albicans in chemically defined medium was used to treat solid Sarcoma 180 tumor cells implanted subcutaneously in Swiss female mice.Neither toxicity nor skin ulcerations surrounding the tumors was observed. Significant tumor inhibition was obtained using different methods to evaluate treatment effectiveness. Comparison of tumor weights after a single treatment (400 mg/kg, ip) on various days after transplantation indicated significant inhibition with a 10–80% regression rate. Multiple doses (800–2,000 mg/kg, ip) regressed 60–90% of all tumors. Subsequent dosage experiments showed an increased percentage of survivors for all treated groups and a significant decrease in tumor size. Studies of the glycoprotein material indicated that it was immunologically active.
Neurovascular flap repair of the foot for sarcoma
Authors: Kovachev D. , Turnbull A. , Chaglassian T. 
Published: February 2007

AbstractWide excision of soft tissues of the foot for sarcoma invariably creates a large defect requiring closure in a way that will withstand the trauma of bearing weight. Neurovascular flap reconstruction provides a thick, well‐vascularized cover with good sensation, functional durability, and brief immobilization.
Malignant melanoma of the lower extremity: Evaluation of 453 patients
Authors: Ariel Irving M. 
Published: February 2007

AbstractFour hundred fifty‐three patients are evaluated regarding 10‐year survival rates. Females comprise 66%, and males the remainder (34%). The absolute 10‐year survival rate was 55.2% post therapy. Females had a remarkably better survival (64%) than the males (42%). Age did not affect the prognosis. Staging was most important in that 167 patients with Stage I had a 10‐year survival of 66%, which dropped for the 263 patients in Stage II (24%), and of the 23 patients classified as Stage III, only one (4%) survived 10 years. Of the 202 patients in clinical Stage I, 102 were subjected to an elective groin dissection which revealed occult metastases to lymph nodes in 35, whose 10‐year survival rate was 49%. In 100 patients, no elective groin dissection was performed, and 41 of these developed metastases to inguinal nodes at a later date. The 10‐year survival for that group was 32% — somewhat lower than the 49%. An elective groin dissection is indicated for invasive melanomas. An eleven percent mortality between the fifth and tenth year after therapy indicates that 10‐year survival rates should be recorded for melanomas.
Malignant carcinoid syndrome: Two case reports
Authors: Spann Joe L. , Van Wormer Dale , Sandlin Michael E. 
Published: February 2007

AbstractThe malignant carcinoid syndrome (MCS) is a rare complication of malignant carcinoid neoplasms, fewer than 200 cases having been reported since its description by Thorson in 1954. Its signs and symptoms vary with the site of the primary neoplasm, and MCS is now recognized as one member of the large family of endocrine tumors ‐ APUDOMAS).Although MCS remains uniformly fatal, significant palliation can be provided some patients with current surgical and chemotherapeutic management. All signs and symptoms in MCS, except evidence of the destruction of the tricuspid and pulmonic valves, can be reproduced experimentally. The factor causing this lethal complication has not been identified.Two previously unreported cases of MCS, each from the gastrointestinal (GI) tract, are presented. This brings the world's total reported cases to approximately 210.
Relationship of chemotherapy on human cancer xenografts in nude mice to clinical response in donor patient
Authors: Fujita Masahide , Hayata Satoshi , Taguchi Tetsuo 
Published: February 2007

AbstractResponsiveness of experimental chemotherapy on human cancer xenografts in nude mice was directly compared with clinical response to the same chemotherapy in their donor patients. These xenografts were 1 line of rectal cancer (H‐26), two lines of gastric cancer (H‐08 and H‐22), and 1 line of breast cancer (H‐62). Experimental chemotherapies studied were single‐drug FT‐207 to four lines of xenografts and a combination of mitomycin C, 5‐FU, and cytosine arabinoside (MFC) to a line of gastric cancer H‐08. Single‐drug treatment with FT‐207 to H‐26 resulted in remarkable retardation of the tumor growth. The comparative treatment with FT‐207 suppository to the donor patient of H‐26 showed appreciable response. All the other chemotherapies to three other lines (H‐08, H‐22, and H‐62) induced no significant response, which was parallel to the corresponding clinical response in each donor patient. The sensitivity to chemotherapeutic drugs was thought to be still preserved in human cancer xenografts in nude mice.
Fine‐needle‐aspiration cytodiagnosis of recurrent malignant melanoma
Authors: Hafström Larsolof , Hugander Anders , Jönsson Per‐ebbe , Lindberg Lars‐Göran 
Published: February 2007

AbstractSixty‐four patients with melanoma (28 with clinical stage I disease and 36 with clinical stages II through IV disease) were fine‐needle biopsied on suspicion of recurrent melanoma. Eighty‐four biopsies were aspirated percutaneously and three at exploratory laparotomy. A tumor mass was present at 81 biopsies. The remaining biopsies were taken with theguidance of liver scan or fluoroscopy. In the patients with the diagnosis of recurrent malignant melanoma the cytodiagnosis was correct in 45 patients out of 47. One patient was diagnosed as breast cancer and one as malignant mesenchymal tumor. Of 40 biopsies considered normal, three were revised to be melanoma. No false‐positive diagnosis was found. The frequency of false‐negative diagnosis was 6%. Fine‐needle‐aspiration cytology is a suitable method t o establish a correct diagnosis when there is a suspicion of recurrent disease during the follow‐up of melanoma patients. The high diagnostic accuracy in patients with enlarged lymph nodes is excellent and makes the method preferable to diagnostic surgical excision biopsies.
Malignant thymoma with extrathoracic metastasis: A case report and review of literature
Authors: Jose Baby , Yu Dmrt Anthony T. , Morgan Thomas F. , Glicksman Arvin S. 
Published: February 2007

AbstractA case of invasive thymoma with metastasis to liver and brain is presented. The incidence, sites of involvement, and the different histological types of metastatic lesions are discussed. Review of the literature shows that the important prognostic factors are the infiltrative nature, the extent of the tumor at the primary site, and associated syndromes like myasthenia gravis and red cell hypoplasia. Patients with noninvasive thymoma have excellent survival by surgery, compared to a reported low (23%) five‐year survival with invasive type. The average time of survival after the appearance of metastasis is about one and one‐half years.
Dental management of head and neck cancer patients
Authors: Carl William 
Published: February 2007

AbstractIn the management of head and neck cancer, dentistry has an important supportive role. Many anatomical and functional changes caused by surgery for the removal of intraoral tumors can be corrected or improved upon by prosthetic dentistry. The control of dental pathology contributes to the immediate and long‐term success of tumor treatment and facilitates rehabilitation.Radiotherapy and loss of teeth do not go hand in hand. Many oral complications associated with radiotherapy can now be avoided or controlled with early preventive and restorative measures.Patients receiving systemic chemotherapy often develop oral complications that require particular attention by the primary physician and the dentist. Control of dental pathology is important in patients receiving chemotherapy because of reduced immune mechanism and increased bleeding tendencies.
Cytochemical localization of lipid, peroxidase, and carbohydrate substances in the dunning prostatic adenocarcinoma R3327H: An ultrastructural analysis
Authors: Arcadi John A. 
Published: February 2007

AbstractThe ultrastructural organization of the cells of the transplantable prostatic adenocarcinoma of the rat, R3327H, has been studied on a cytochemical level. The techniques used were those to localize lipids, peroxidase, and carbohydrate‐like substances.This study has clearly shown that there are, in the tumor cells and not in normal prostatic epithelial cells, both lipid compartments with an intense peroxidase membrane. Within the lipid “droplet” we find it to be compartmentalized by conconavalan A‐positive material. These observations suggest that this tumor cell may be a “degenerating” or old cell. It may well be that this cancer is a disease of dying cells ‐ the degrading consequence of cell growth.
Characterization of in vivo suppression of syngenic tumor by allogenic effector cells
Authors: Sugarbaker Paul H. , Sugarbaker Stephen P. , Pun Pattle P. 
Published: February 2007

AbstractThe purpose of this study was to characterize the effects of allogenic splenocytes transferred with tumor cells, subcutaneously, to a host syngenic for tumor cells. Cytotoxic effector cells usually resulted in tumors less than half the size of controls at E:T of 10:1. Primary immune splenocytes were more effective than hyperimmune splenocytes in delaying tumor growth. Actively cytotoxic splenocytes by in vitro 51Cr release assay were required for delayed tumor growth; memory cell populations were not effective. Delayed tumor growth correlated with in vitro cytotoxicity of primary immune splenocytes; however, hyperimmune splenocytes, even though they possessed greater in vitro cytotoxic responses, showed lesser tumor suppression in vivo. T cells were necessary for tumor suppresion, as treatment of B6AF1 effector cells with anti‐Thy 1.2 serum abrogated suppression; T cell enrichement by nylon‐wool treatment of effector cells increased tumor suppression. Delay in tumor growth was an in vivo phenomenon, for anti‐Thy 1.2 serum in AKR hosts abrogated the effect of Thy 1.2 effector cells.
Juvenile nasopharyngeal angiofibroma
Authors: Vadivel Sakthi P. , Bosch Antonio , Jose Baby 
Published: February 2007

AbstractSeven cases of juvenile nasopharyngeal angiofibroma were seen in the Division of Radiation Oncology of the Department of Human Oncology, University of Wisconsin Hospitals from 1961 to 1977. The method of treatments and the end results are discussed. The clinical manifestations and the biological nature of this tumor are analyzed in detail, along with treatment recommendations.
Hepatic catalase in rats bearing walker tumor in the brain
Authors: Gershbein Leon L. 
Published: February 2007

AbstractRats were injected with 105 cells of Walker carcinosarcoma 256 in ascites form into discrete areas of the brain (RAS, midbrain‐hypothalamus, and anterior and posterior cortex), and at necropsy on the sixth day postoperation the animals were sacrificed, the brains were examined for tumors, and liver homogenates were analyzed for catalase content. The latter was significantly depressed in the tumor‐bearing animals as compared to the corresponding saline‐injected controls. The findings are of interest considering that the tumors were relatively small; however, they occupied significant areas of the entire brain. Although small or moderate body weight losses were encountered, the inhibitory effect was not due to inanition, a known depressant. Liver catalase was little altered in rats with solid tumors in the various brain areas originating from fragments measuring 1 mm3 and harvested from donors with intramuscular Walker tumor, as was also the case with tumor‐free rats submitted to hypothalamic lesioning. Brain catalase levels were not affected by any of the treatments.
Chemotherapy against human melanoma in the hamster cheek pouch
Authors: Dufour Frank D. , Okada Geoffrey T. , Mah Stuart G. , Morton Donald L. 
Published: February 2007

AbstractHuman malignant melanoma was transplanted to the cheek pouch of immuno‐suppressed (corticosteroid‐treated) hamsters. Significant differences were observed in tumor growth constants for animals treated with methotrexate, DTIC, BCNU, and vincristine (P < 0.05) compared to controls. However, no appreciable effect was demonstrated for Adriamycin, 5‐FU, and cytoxan. In addition, single doses as high as 400 mg/kg body weight of methotrexate were no more effective than other agents now used against this neoplasm.
Simultaneous bilateral neck dissection
Authors: Razack Mohamed S. , Sako Kumao , Baffi Raul , Patel Jashbhaik 
Published: February 2007

AbstractThe presence of bilateral cervical nodal metastases secondary to intraoral, laryngeal and hypopharyngeal carcinoma was once thought to make the condition inoperable and “incurable”. It was also stated that the mortality from bilateral neck dissection would most likely exceed the number of patients cured by this procedure. We have a number of patients who had and tolerated it well, with a few surviving even for three and five years. We wish to report the morbidity, mortality and cure rate with simultaneous bilateral neck dissection in patients who had this procedure.From January 1960 to December 1975, 61 simultaneous bilateral neck dissections were performed as a part of oral, laryngeal or hypopharyngeal resections. Fifty‐three patients had a classical bilateral radical neck dissection while in six patients one of the internal jugular veins and in two patients both of these veins were preserved. Six out of 61 (9%) patients had received radiation therapy previously. Nodal clearance was done in all the patients. Six out of 61 (8%) patients died within one month, three of whom never regained consciousness and died within 48 hours of the procedure. Sixty‐three percent (39/55) of patients developed immediate postoperative facial swelling and wound infection. Thirty‐six percent (22/55) had orocutaneous fistulae; of these, 11% (7/55) had carotid artery blowouts. Sixteen percent (10/55) of patients had significant pulmonary complication. The percentage of patients who were free of disease at 6 months, 1 year, 1 1/2 years, 3 years, and 5 years following the procedure was 54% (26/48), 37% (18/48), 29% (14/48), 20% (10/48) and 12.5% (6/48), respectively.It appears from the present study that although bilateral neck dissection has a high postoperative morbidity and mortality rate, it can effectively control the disease in a significant number of patients with a 20% three‐year and 12.5% five‐year cure rate.
Treatment with steroids of a giant cell granuloma of the maxilla
Authors: Body Jean‐Jacques , Jortay Albert M. , De Jager Robert , Ardichvili Daniel 
Published: February 2007

AbstractThis case report of giant cell granuloma involving the maxilla is of particular interest for two reasons: the locally aggressive clinical course contrasting with the diagnosis of a benign disease and the spectacular, although transient, response under steroid treatment. Corticotherapy should be further tested in cases of invasive or recurring giant cell granuloma.
Enzymatic and ultrastructural study of lysosomes in rats bearing radiation‐induced thyroid follicular carcinoma
Authors: Starling James R. , Clifton Kelly H. , Norback Diane H. 
Published: February 2007

AbstractRadiation‐induced well‐differentiated and poorly differentiated follicular thyroid cancers were transplanted into the intrascapular fat pads of male Fisher 144 rats. The tumors grew in the recipient rats and after a time interval were removed and studied along with normal rat thyroids for lysosomal activity and ultrastructural characteristics. Plasma from experimental and control rats was also studied for lysosomal activity. Rats with radiation‐induced thyroid carcinoma had a decrease in growth rate compared with normal rats. There was no significant increase in plasma lysosomal enzymes in the experimental rats. Well‐differentiated thyroid carcinomatous tissue showed increased total activities of lysosomal enzymes as well as a difference in subcellular distribution compared with normal and poorly differentiated carcinomatous tissue. Electron microscopy of normal and carcinomatous tissue demonstrated the greatest number of lysosomes in the well‐differentiated carcinoma and the fewest in the poorly differentiated carcinoma.
Fatal pulmonary tumor embolization following peritoneovenous shunting for malignant ascites
Authors: Smith Robert R. L. , Sternberg Stephen S. , Paglia Michael A. , Golbey Robert B. 
Published: February 2007

AbstractA 44‐year‐old white male with pseudomyxoma peritonei and intractable malignant ascites is described. This patient underwent three peritoneovenous shunt procedures utilizing first the LeVeen shunt and finally the Denver shunt in a surgical attempt at palliative decompression of his malignant ascites. The peritoneovenous shunts resulted in massive tumor embolization to the pulmonary vasculature, clinically asymptomatic disseminated intravascular coagulation, and partial thrombosis of the superior vena cava. The pulmonary tumor embolization was manifest clinically as moderate pulmonary hypertension with increased pulmonary vascular resistance and persistent hypoxia.
Arterial embolus as a complication of staging laparotomy
Authors: Kaiser C. William 
Published: February 2007

AbstractStaging laparotomy is widely utilized in the management of selected patients with Hodgkin disease. The local trauma produced by extensive en bloc periaortic node removal for detection of subdiaphragmatic disease may predispose the patient to arterial thromboembolic events. This procedure seems undesirable and unnecessary especially in patients known to have lymphocyte‐depleted and mixed‐cellularity‐type disease or in those found to have splenic involvement by intraoperative sectioning. These patients will often have microscopic tumor in their random needle and wedge liver biopsies taken at surgery; extensive periaortic tissue sampling is therefore unnecessary. A further concern is that such patients are likely to receive postoperative steroid chemotherapy, which has been associated with a hypercoagulative state.
Tissue isoantigens A, B, and H in carcinoma of the cervix uteri: Their clinical significance
Authors: Gupta Saroj , Gupta Y. N. , Singh Indra Jeet , Sanyal B. , Khanna Shail , Rani Abha 
Published: February 2007

AbstractA specific red cell adhesion test was done in 243 patients with carcinoma of the cervix uteri and showed the presence of isoantigens in only 27.16% of the patients with infiltrating squamous cell carcinoma. There was a gradual loss of isoantigens during the development of carcinoma. The test can be usefully employed in studying the evolution of the disease. The negativity of the test was found to increase as clinical severity of the disease increases. Also, the highest percentage (57.57%) of retained isoantigen was found in large‐cell nonkeratinizing carcinoma, a well‐differentiated type for the cervix. Follow‐up studies suggest that the loss of antigen indicates probable metastasis and a poor prognosis.
Male breast cancer
Authors: Gupta Saroj , Pant Girish C. , Gupta Saroj 
Published: February 2007

AbstractThis study comprises 27 cases of male breast cancer treated at the University Hospital from 1966 through 1978. Its incidence was 0.53% of all cancer in males and 3.2% of all mammary cancers. Mean age was 52 years old. Lump in the breast was the commonest presenting feature in all patients followed by skin ulceration in 44.4% of cases. The average duration of symptoms was 16 months. Twenty‐five patients had infiltrating duct carcinoma and two had papillary carcinoma. Two cases were in stage I, 10 in stage II, 11 in stage III, and 4 in stage IV. Of the 12 patients in stages I and II who underwent radical mastectomy, the axillary lymph nodes were pathologically negative in stage I and positive in stage II. The nodes were clinically involved in stages III and IV. Simple mastectomy followed by radiotherapy were used in stage III cancer and all patients in stage IV cancer had only biopsy and palliative chemotherapy. Bilateral orchidectomy followed by estrogen gave only marginal benefit in terms of survival and objective regression. Only four patients, two each in stages I and II, are alive and well for more than five years. These include two cases of papillary carcinoma. Poor prognosis in this series was exclusively determined by axillary lymph node involvement, although other factors such as shorter span of symptoms, younger age group, higher incidence of skin involvement, and invasive nature of carcinoma also appear to be significant.