bluuebunny/crossref_metadata_2025_split huggingface dataset:
Problematic alcohol use among gay, bisexual, and other men who have sex with men in Canada: the role of proximal stressors and anxiety
Authors: Zahran Adhm , Dermody Sarah S. , Berlin Graham W. , Palma Paolo A. , Skakoon-Sparling Shayna , Noor Syed W. , Lachowsky Nathan J. , Grace Daniel , Cox Joseph , Moore David M. , Lambert Gilles , Zhang Terri H. , Dvorakova Milada , Jollimore Jody , Lal Allan , Hart Trevor A. 
Published: February 2024

Abstract
Background
Gay, bisexual, and other men who have sex with men (GBM) report high rates of problematic alcohol use, anxiety, and depression. This may, in part, be due to stressors related to their sexual identity (i.e., minority stressors). However, few studies have examined both distal and proximal stressors, as well as the specific psychological mechanisms by which these stressors may be related to alcohol use outcomes, in a representative sample of GBM. We explored the relationship between distal and proximal stressors and alcohol use outcomes, as well as the role of anxiety and depression as potential mediators of these relationships.

Methods
We analyzed the baseline data of 2,449 GBM from Engage, a cohort study of sexually active GBM recruited using respondent-driven sampling (RDS) in Montreal, Toronto, and Vancouver from February 2017 to August 2019. Using structural equation modeling, we examined the associations between distal minority stressors (i.e., experiences of heterosexist harassment, rejection, and discrimination), proximal minority stressors (i.e., internalized homonegativity, concerns about acceptance, concealment, and lack of affirmation), anxiety and depression, and alcohol consumption and alcohol use problems. RDS-adjusted analyses controlled for age, income, sexual orientation, ethnicity, recruitment city, and HIV serostatus.

Results
There were positive direct associations between distal stress and proximal stress, anxiety, and depression, but not alcohol use outcomes. Proximal stress had a positive direct association with anxiety, depression, and alcohol use problems, but not alcohol consumption. Anxiety was positively associated with alcohol consumption and alcohol use problems. Depression was negatively associated with alcohol consumption but not alcohol use problems. Regarding indirect effects, distal stress was associated with alcohol use outcomes via proximal stress and anxiety, but not via depression.

Conclusions
We found support for a minority stress model as it relates to alcohol use outcomes among GBM. Findings suggest that proximal minority stress and anxiety differentially impact the problematic alcohol use among GBM who experience heterosexist discrimination. Clinical providers should consider incorporating the treatment of proximal minority stressors and anxiety into existing alcohol interventions for GBM.
A review on traditional Chinese medicine natural products and acupuncture intervention for Alzheimer’s disease based on the neuroinflammatory
Authors: Chen Zhihan , Wang Xinrui , Du Simin , Liu Qi , Xu Zhifang , Guo Yi , Lin Xiaowei 
Published: February 2024

AbstractAlzheimer’s disease (AD) is a neurodegenerative disease with insidious onset and progressive development. It is clinically characterized by cognitive impairment, memory impairment and behavioral change. Chinese herbal medicine and acupuncture are important components of traditional Chinese medicine (TCM), and are commonly used in clinical treatment of AD. This paper systematically summarizes the research progress of traditional Chinese medicine natural products and acupuncture treatment of AD, which combined with existing clinical and preclinical evidence, based on a comprehensive review of neuroinflammation, and discusses the efficacy and potential mechanisms of traditional Chinese medicine natural products and acupuncture treatment of AD. Resveratrol, curcumin, kaempferol and other Chinese herbal medicine components can significantly inhibit the neuroinflammation of AD in vivo and in vitro, and are candidates for the treatment of AD. Acupuncture can alleviate the memory and cognitive impairment of AD by improving neuroinflammation, synaptic plasticity, nerve cell apoptosis and reducing the production and aggregation of amyloid β protein (Aβ) in the brain. It has the characteristics of early, safe, effective and benign bidirectional adjustment. The purpose of this paper is to provide a basis for improving the clinical strategies of TCM for the treatment of AD.
Graphical Abstract
Effects of a chronotype-adapted diet on weight loss, cardiometabolic health, and gut microbiota: study protocol for a randomized controlled trial
Authors: Dinu Monica , Lotti Sofia , Pagliai Giuditta , Napoletano Antonia , Asensi Marta Tristan , Giangrandi Ilaria , Marcucci Rossella , Amedei Amedeo , Colombini Barbara , Sofi Francesco 
Published: February 2024

Abstract
Background
Obesity and its associated health complications have become a global public health concern, necessitating innovative approaches to weight management. One emerging area of research focuses on the influence of chronotype, an individual’s preferred timing for daily activities, on eating habits, weight regulation, and metabolic health. Recent observational studies suggest that the misalignment between an individual’s chronotype and external cues, such as meal timing, may contribute to metabolic dysregulation and obesity, but evidence from intervention studies is still limited. This study protocol describes a randomized controlled trial designed to explore the effects of a chronotype-adapted diet, compared with a diet with a conventional calorie distribution, on weight loss, cardiometabolic health, and gut microbiota composition.

Methods
A total of 150 overweight/obese adults will be recruited for this 4-month parallel-group, randomized, two-arm, open-label, superiority trial with 1:1 allocation ratio. Participants will be randomly assigned to either the intervention group or the control group. The intervention group will receive a low-calorie chronotype-adapted diet with a calorie distribution adapted to the individual chronotype (morning or evening), optimizing meal timing according to their peak metabolic periods. The control group will follow a standardized low-calorie healthy eating plan without considering chronotype. Both diets will have equivalent daily calorie content, adjusted according to gender and starting weight. Anthropometric measurements, body composition, blood, and fecal samples will be obtained from each participant at the beginning and the end of the study. The primary outcome is weight change from baseline. Secondary outcomes are changes from baseline in body mass index (BMI), fat mass, lipid and glycemic profile, fecal microbiota profile, and short-chain fatty acids (SCFAs).

Discussion
The results of this randomized controlled trial have the potential to advance our understanding of the complex interactions between chronotype, diet, body weight, and health outcomes. By providing evidence for personalized dietary interventions based on individuals’ circadian preferences, this research could offer insights into personalized nutrition strategies. Such knowledge could guide the development of innovative dietary interventions to optimize the prevention and management of overweight and obesity, while also improving the risk profile of these individuals.

Trial registration
ClinicalTrials.gov NCT05941871. Registered on 18 May 2023.
Modified Histopathological Grading Optimizes Prediction of Survival Outcomes in Small Intestinal Neuroendocrine Tumors
Authors: Daskalakis Kosmas , Tsoli Marina , Wallin Göran , Kogut Angelika , Srirajaskanthan Raj , Harlow Christopher , Giovos Georgios , Weickert Martin O , Kos-Kudla Beata , Kaltsas Gregory 
Published: February 2024

Abstract

Context
One of the major prognostic indices in neuroendocrine tumors (NETs) is Ki67 proliferation index.

Objective
To identify optimal grading Ki67 cutoffs to delineate differences in prognosis of patients with small intestinal NETs (SI-NETs).

Methods
Multicenter retrospective cohort analysis of 551 SI-NET patients diagnosed from 1993 through 2021 at 5 European referral centers with a mean (±SD) follow-up time of 51.5 (±52.9) months, measuring rates of overall survival (OS) and event-free survival (EFS).

Results
Median age at baseline was 62.3 (range, 17-90) years; 252 (45.7%) patients were female. All SI-NETs were well-differentiated, with 326 being grade 1 (G1; 59.2%), 169 G2 (30.7%), and 8 G3 (1.5), while 48 tumors were unspecified grade (8.7%). The median Ki67 was 2% (range, 1%-70%). At baseline, 247 (44.8%) patients had distant metastases (stage IV), 217 locoregional disease (41.1%; stage III), while 29 (7.1%) and 25 (4.5%) presented at stages II and I, respectively. Median OS was 214.7 (95% CI, 152.7-276.6) months and median EFS was 79.8 (68.2-91.5) months. In multivariable Cox-regression OS analysis, the proposed modified histopathological Ki67 grading system (Ki67 5%-10% group: HR = 2.2 [95% CI, 1.15-4.31], P = .018 and Ki67 ≥ 10% group: HR = 5.11 [2.87-9.09], P &lt; .001), age (HR = 1.07 [1.04-1.09], P &lt; .001), Charlson Comorbidity Index (HR = 1.08 [1-1.16], P = .028), and TNM stage (HR = 1.79 [1.05-3.06], P = .034) were independent predictors for death. Pertinent EFS analysis confirmed the proposed modified histopathological Ki67 grading system (Ki67 ≥ 10% group: HR = 4.01 [2.6-6.37], P &lt; .001) and age (HR = 1.04 [1.02-1.05], P &lt; .001) as independent predictors for recurrence, progression, and/or death.

Conclusion
Ki67 proliferation index was a strong and independent predictor of OS and EFS. A modified histopathological grading system applying Ki67 cutoffs of 5% and 10% could be superior to predict differences in SI-NET patient survival outcomes.
Valsalva manoeuvre-induced pneumothorax and pneumomediastinum in a COVID-19 patient with ARDS: an unusual mechanism for this complication
Authors: Weerawardane Totawatte Don Srilak , Bürgisser Nils , Berner Amandine , Coen Matteo 
Published: February 2024

Background: Until now, only a few cases of Valsalva-induced barotraumas (pneumothorax, pneumomediastinum and subcutaneous emphysema) have been described, and none of them among COVID-19 patients. Case description: A man in his 50s was admitted for SARS-CoV-2-related acute respiratory distress syndrome (ARDS). Initial evolution was favourable with non-invasive ventilatory support, high-flow oxygen nasal cannula and the best supportive drugs available at the time. During the Valsalva manoeuvre while defecating, the patient reported sudden chest pain and showed a new acute hypoxemic respiratory failure due to a pneumothorax. It led to multiple complications (pulmonary embolism, haemoptysis, and cardiac arrest), and despite the best supportive care, led to the patient's death. Discussion: The Valsalva manoeuvre can be an overlooked cause of pneumothorax in patients with COVID-19. Predisposition to barotrauma in COVID-19 patients could be explained by several factors, including the extensive use of non-invasive and invasive ventilation during the pandemic, and the histological changes observed in the lungs of those infected with COVID-19. Conclusion: We report the first description of a Valsalva-induced barotrauma in a COVID-19 infection. We emphasise the importance of treating constipation particularly in severe COVID-19 cases, to prevent complications such as barotrauma.
Ischaemic gastropathy: an under-recognised cause of abdominal pain
Authors: Touza Masara , Emehinola Oluwatosin , Ali Ruhma , Jamil Asma , Hussain Muhammad , Atiyat Raed , Miller Richard 
Published: February 2024

Ischaemic gastropathy is an under-recognised phenomenon with a particularly poor prognosis, where early diagnosis is crucial for successful medical intervention and the prevention of life-threatening complications. We present a case involving a 42-year-old female with no history of vascular insufficiency who developed ischaemic gastropathy following a prolonged stay in the intensive care unit, from septic shock secondary to Escherichia coli bacteraemia due to complicated acute appendicitis. This case underscores the importance of the physician’s awareness regarding this rare entity and the necessity to consider it in the differential diagnosis of abdominal pain and haematemesis. Prompt diagnosis and treatment may significantly improve survival outcomes in this less-documented pathology, especially in the younger adult population.
TEMAS CONTROVERSOS NA EDUCAÇÃO
Authors: Melo Marlene Rios , Andrade Tatiana Santos 
Published: February 2024

A pandemia, causada pelo vírus Sarcov-2, denominada de Covid-19, tem seu surgimento relacionado a degradação ambiental. Segundo o Relatório do PNUMA (2020) existe uma relação direta entre a destruição ambiental e o desenvolvimento de doenças zoonóticas e ainda, aponta que a manutenção do modo predatório de exploração do meio ambiente implicará no surgimento mais frequente de novas pandemias. Nesse sentido, considerou-se necessário que os processos educativos contemplem debates sobre a compreensão não só do conhecimento científico envolvido nas tecnologias de produção e seus efeitos ao meio ambiente natural, mas também as implicações sociais, políticas e econômicas envolvidas. Essa necessidade levou à estruturação de Projeto de Extensão, parceria entre duas Instituições Federais de Ensino, visando ampliar e melhorar a compreensão do fenômeno pandêmico através de palestras on-line (lives) com pesquisadores e grupos de resistência comprometidos com a preservação ambiental. O objetivo dessa pesquisa contempla, a partir da efetivação do projeto de extensão, a interpretação do fenômeno: os diálogos desenvolvidos durante as apresentações, feitas pelos pesquisadores e líderes de grupos de resistência, sobre as relações entre questões ambientais e surgimento de pandemias. Após a percepção desse fenômeno, formulou-se a questão de pesquisa, que orientou o olhar compreensivo: as discussões estabelecidas pelos palestrantes e a constituição de temas controversos envolvendo a relação entre impactos ambientais e surgimento de pandemias. A análise apontou para cinco temas controversos, bem como sugestão de formas de mediação desses temas na escola apoiada em pressupostos Frerianos e associada a perspectiva educacional CTS.
voz e a vez dos podcasts na educação linguística em espanhol
Authors: De Freitas Batista Fabiana , Kanashiro Daniela 
Published: February 2024

O presente artigo objetiva discutir as potencialidades do gênero discursivo podcast na educação linguística, especialmente, em língua espanhola. A metodologia utilizada é a de pesquisa qualitativa-interpretativista, proposta por Stake (2011), com perfil bibliográfico. Kenski (2003) e Moran et al. (2012) corroboram com a ideia de que as tecnologias transformaram também o contexto educacional. Dessa forma, trazemos parte da história das tecnologias voltadas para a educação, ancoradas sobretudo em Paiva (2015). Na sequência, expomos elementos caracterizadores do gênero discursivo podcast, segundo Carvalho, Aguiar e Maciel (2009), Medeiros (2006) e Villarta-Neder e Ferreira (2020). Discorremos também como o podcast pode contribuir para a escuta e a produção oral em língua adicional. Por fim, apresentamos uma proposta de atividades com o uso de podcast em língua espanhola para a educação básica. Como material autêntico, de fácil acesso, abordando temáticas atuais, avaliamos que esse arquivo de áudio pode contribuir significativamente para o desenvolvimento da escuta e da fala em língua adicional, a depender de como o docente explore-o em sala de aula.
Arquivos pedagógicos, leitura e escrita: uma proposta para o ensino fundamental.
Authors: Cruz de Oliveira Garcia Fernanda , Rodrigues Andréa 
Published: February 2024

Neste texto, apresentamos e discutimos a proposta de um caderno de atividades baseado na ideia de criação de um arquivo pedagógico (Indursky, 2019), acompanhado de sugestões de práticas de leitura e de escrita para professores e estudantes de ensino fundamental. Esse trabalho propositivo foi realizado no âmbito do Mestrado Profissional em Letras, e começou a ser pensado ainda durante a pandemia, a partir de uma portaria emitida por esse programa, que indicou a possibilidade de produzir materiais didáticos sem a obrigatoriedade anterior de que houvesse um projeto de natureza interventiva, dadas as condições de ensino remoto durante o período pandêmico. O trabalho parte da abordagem teórica da Análise do Discurso (AD) materialista, especialmente as noções de arquivo pedagógico proposto por Freda Indursky (2019) , leitura e autoria na escola (Orlandi, 1988; 2006).
Model Simulation of Continuous Time Markov Chain Susceptible Infected Recovered-Bacterial Population for Cholera Disease
Authors: Hidayati Aulia Maulani Syifa Nur , Respatiwulan Respatiwulan , Subanti Sri 
Published: February 2024

<p>Epidemic is an outbreak of an infectious disease rapidly in a population at a certain place and time. Epidemic models are used to explains the spread pattern of disease. The continuous time Markov chain susceptible infected recovered-bacterial population in the aquatic reservoir (CTMC SIR-B) model is a stochastic model, which considers the effect of bacterial population. The human population are classified into 3 groups. There are susceptible, infected, and recovered groups. Then, there are bacterial population which can infectious the cholera disease to human. CTMC SIR-B model considers treatment and water sanitation parameters. The spread of cholera disease can be modeled as CTMC SIR-B. Cholera is an acute intestinal infectious disease caused by the bacterium Vibrio cholerae. Cholera can be transmitted through the human digestive system. The symptoms of cholera disease are diarrhea, vomiting, and dehydration. The dehydration if not handled properly, may cause death. The aims of this research are to build and simulate the CTMC SIR-B model for cholera disease. The result of the model simulation shows that there is no significant difference between various values of treatment and water sanitation parameters. The pattern of the cholera disease spread describes that the transmission of cholera can occur from human to human even though there is no population of bacteria in the aquatic reservoir.</p><p><em></em><strong><em>Keywords</em></strong><strong><em>: </em></strong><em>cholera</em><em>; ctmc sir-b;</em><em> epidemic model</em><em>;</em><em> stochastic.</em></p><p> </p>
Invasion of privacy or structural violence? Harassment against women in public transport environments: A systematic review
Authors: Useche Sergio A. , Colomer Natura , Alonso Francisco , Faus Mireia 
Published: February 2024

Background
Despite being neglected for several decades, and in many countries, public transport environments have transformed into a reflection of social disparities and inequalities. Among these issues, harassment–a pervasive and worldwide gendered dynamic–has been demonstrated to negatively impact women’s behavioral trends, daily opportunities, and health impacts, as well as safety and security outcomes.

Aim
This systematic review aimed to examine a set of studies analyzing harassment against women in public transport environments, with a focus on key issues such as its prevalence, impact on transport dynamics, preventive strategies, and policing avenues documented in the scientific literature.

Method
A total of 575 indexed articles were filtered using the PRISMA methodology, resulting in a final selection of 28 original articles directly addressing the issue up to December 2023. Search strategies were developed and implemented across WOS, Scopus, NCBI, Google Scholar, and APA databases.

Results
Besides high frequency, widespread underreporting, and adverse effects on women’s safety, this review has identified correlations between harassment and travel behavioral adaptations. Furthermore, it reveals a noticeable disparity between the existing measures and those perceived as more effective by potential victims. These findings underscore the pressing need to listen to and promote the inclusion of women in decision-making regarding transport affairs.

Conclusion
The findings of this systematic review suggest that, despite a slightly limited body of research, the impact of transport harassment on women’s health and welfare is consistently supported in the literature. In addition to being largely explained by existing inequalities rooted in social determinants, transit harassment further exacerbates gender gaps, gaining prospective importance for transport settings.
The psychosocial experiences of pregnant women in the early stages of the COVID-19 pandemic: A retrospective qualitative study
Authors: Kusi Amponsah Abigail , Boateng Edward Appiah , Armah Jerry , Dompim Joana Kyei , Gyamfi Douglas , Lomotey Alberta , Annobil Faithful Adwoa , Amankrah Amena Ekua , Youshah Rifka Abdallah , Beauty Elizabeth Uzoka , Diji Francis , Bam Victoria 
Published: February 2024

Background
Pregnant women are among the most vulnerable and suffer the most during pandemics, according to earlier studies. Pregnant women had to seek healthcare for both themselves and their unborn child(ren) in the wake of the COVID-19 pandemic, which was unprecedented. Pregnant women’s psychosocial experiences during pandemics are crucial since they both directly and indirectly affect the course of pregnancy and childbirth. The study therefore sought to explore the psychosocial experiences of pregnant women during the COVID-19 pandemic.

Methods
In this retrospective qualitative study, 15 nursing mothers who were attending a postnatal clinic at the Kwame Nkrumah University of Science and Technology (KNUST) hospital in Ghana were recruited. Individual interviews were conducted with mothers who were pregnant between March and December 2020. The audio-recorded interviews were transcribed verbatim and inductively analysed into themes.

Results
Nursing mothers were aged 25–30 years and had infants ranging from 5 months to 15 months. Thirteen (13) were married and two were single. Two (2) major themes and five (5) subthemes emerged from the study. The unpleasant feelings connected to the potential for contracting COVID-19 and experiencing stress were described by the theme, “Fear and Stress”. Participants’ social experiences (support from significant others), alterations in daily routine and the economic impact because of the pandemic were presented as the “Socioeconomic impact”.

Conclusion
Pregnant women go through several challenges during pregnancy such as perceived stress and anxiety. These are likely to heighten during a pandemic, as presented in the study. They therefore need emotional and psychosocial support in such uncertain times to improve outcomes of pregnancy.
EDUCAÇÃO FÍSICA E MUDANÇAS SOCIAIS AO LONGO DA CARREIRA DOCENTE
Authors: Bremm de Oliveira Ivan , Felipe Ernst Frizzo Giovanni 
Published: February 2024

O artigo objetiva analisar a carreira docente e as mudanças sociais ao longo do tempo para o professorado de EF da RMEPel. Trata-se de um estudo de caso descritivo com 11 docentes de EF acima de 20 anos de experiência docente a partir de entrevistas semiestruturadas seguidos da análise de conteúdo. As discussões e análises indicam que na EF escolar ao longo da carreira houve a exigência de formação específica em EF e início da participação dos mesmos nos conselhos escolares, porém, a falta de infraestrutura e material para as aulas e a perda de espaço da EF na escola percorreu toda a carreira. Em relação as mudanças e transformações sociais de ordem capitalista e as políticas públicas neoliberais, as mesmas afetaram negativamente a organização do trabalho pedagógico em EF e da Educação como um todo, pois ocasionaram a desvalorização e descaracterização da função docente.