bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interference‐aware feedback based iterative Hungarian approach to allocate multiple channels to multiple D2D pairs to maximize underlay D2D network capacity
Authors: Singh Sengar Aditya , Gangopadhyay Ranjan , Debnath Soumitra 
Published: April 2024

SummaryThe spectral efficiency of a cellular network can be increased significantly by allowing spatial reuse of its spectrum by an underlay device‐to‐device (D2D) network. In an underlay D2D network, devices in close vicinity are allowed to establish low‐power direct links with little to no involvement of the base station. In order to increase the spectral efficiency and the number of devices with channel access, multiple D2D pairs may transmit in each cellular channel. Additionally, each pair can be allowed to utilize multiple channels to transmit so as to maximize the D2D network capacity. This multiple‐pair multiple‐channel (MPMC) strategy is quite appealing but is limited by the resultant additional aggregate interference and the inherent complexity, hence necessitating the need for a fast and reliable channel allocation scheme. This work proposes a polynomial‐time iterative Hungarian assignment with feedback (IHAF) algorithm for multiple channel allocations amongst multiple D2D pairs that increases the D2D network capacity manifold while maintaining the desired minimum capacity for each cellular user.
Successful endoscopic treatment of a huge trichobezoar in a 10‐year‐old girl
Authors: Matsuura Ko , Oura Shoji , Ishibashi Kohei , Matsumoto Yoichi , Ono Wataru 
Published: April 2024

AbstractA 10‐year‐old girl was admitted to our hospital due to acute pancreatitis. Computed tomography showed an intra‐gastric mass containing multiple small air bubbles. Ultrasound showed a well‐circumscribed large oval mass with a broad acoustic shadow. Endoscopy revealed a huge trichobezoar with many movable hairs, being judged by the cause of acute pancreatitis. Due to the parents’ strong preference not to leave any surgical scars on their daughter, the patient underwent endoscopic treatment. The trichobezoar grasped with a snare was too large to pass through the esophageal‐gastric junction. In addition, the outer layer of the trichobezoar was too hard to be cut with conventional endoscopic devices but was successfully cut with a FlushKnife. The content of the trichobezoar was much softer than its hard surface but needed appropriate counter‐traction to be torn off the tissue. Two alligator forceps via a dual‐channel multi‐bending scope were able to give sufficient counter‐traction to the inner tissue of the trichobezoar, successfully removing the trichobezoar through piece‐by‐piece tearing off. All the endoscopic procedures took seven hours for the complete trichobezoar removal. The total weight of the dissected mass was 180 g. The girl resumed eating on the next day and was discharged on the third day. Physicians should note that a medical team with full endoscopic expertise can remove huge trichobezoars using a FlushKnife, a dual‐channel multi‐bending scope, and two alligator forcepses.
Prediction of rock mass classification in tunnel boring machine tunneling using the principal component analysis (PCA)–gated recurrent unit (GRU) neural network
Authors: Man Ke , Wu Liwen , Liu Xiaoli , Song Zhifei , Li Kena , Kumar Nawnit 
Published: April 2024

AbstractDue to the complexity of underground engineering geology, the tunnel boring machine (TBM) usually shows poor adaptability to the surrounding rock mass, leading to machine jamming and geological hazards. For the TBM project of Lanzhou Water Source Construction, this study proposed a neural network called PCA–GRU, which combines principal component analysis (PCA) with gated recurrent unit (GRU) to improve the accuracy of predicting rock mass classification in TBM tunneling. The input variables from the PCA dimension reduction of nine parameters in the sample data set were utilized for establishing the PCA–GRU model. Subsequently, in order to speed up the response time of surrounding rock mass classification predictions, the PCA–GRU model was optimized. Finally, the prediction results obtained by the PCA–GRU model were compared with those of four other models and further examined using random sampling analysis. As indicated by the results, the PCA–GRU model can predict the rock mass classification in TBM tunneling rapidly, requiring about 20 s to run. It performs better than the previous four models in predicting the rock mass classification, with accuracy A, macro precision MP, and macro recall MR being 0.9667, 0.963, and 0.9763, respectively. In Class II, III, and IV rock mass prediction, the PCA–GRU model demonstrates better precision P and recall R owing to the dimension reduction technique. The random sampling analysis indicates that the PCA–GRU model shows stronger generalization, making it more appropriate in situations where the distribution of various rock mass classes and lithologies change in percentage.
Stevioside Ameliorates Palmitic Acid–Induced Abnormal Glucose Uptake via the PDK4/AMPK/TBC1D1 Pathway in C2C12 Myotubes
Authors: Zhang Changfa , Li Shuai , Li Likang , Wang Ruoting , Luo Shiming , Li Guowei 
Published: April 2024

ABSTRACTBackgroundStevioside (SV) with minimal calories is widely used as a natural sweetener in beverages due to its high sweetness and safety. However, the effects of SV on glucose uptake and the pyruvate dehydrogenase kinase isoenzyme (PDK4) as an important protein in the regulation of glucose metabolism, remain largely unexplored. In this study, we used C2C12 skeletal muscle cells that was induced by palmitic acid (PA) to assess the effects and mechanisms of SV on glucose uptake and PDK4.MethodsThe glucose uptake of C2C12 cells was determined by 2‐NBDG; expression of the Pdk4 gene was measured by quantitative real‐time PCR; and expression of the proteins PDK4, p‐AMPK, TBC1D1 and GLUT4 was assessed by Western blotting.ResultsIn PA‐induced C2C12 myotubes, SV could significantly promote cellular glucose uptake by decreasing PDK4 levels and increasing p‐AMPK and TBC1D1 levels. SV could promote the translocation of GLUT4 from the cytoplasm to the cell membrane in cells. Moreover, in Pdk4‐overexpressing C2C12 myotubes, SV decreased the level of PDK4 and increased the levels of p‐AMPK and TBC1D1.ConclusionSV was found to ameliorate PA‐induced abnormal glucose uptake via the PDK4/AMPK/TBC1D1 pathway in C2C12 myotubes. Although these results warranted further investigation for validation, they may provide some evidence of SV as a safe natural sweetener for its use in sugar‐free beverages to prevent and control T2DM.
Efficacy of a Comprehensive Weight Reduction Intervention in Male Adolescents With Different FTO Genotypes
Authors: Roumi Zahra , Salimi Zahra , Mahmoudi Zahra , Mobarakeh Khadijeh Abbasi , Ladaninezhad Maryam , Zeinalabedini Mobina , Keshavarz Mohammadian Mohammad , Shamsi‐Goushki Ali , Saeedirad Zahra , Bahar Bojlul , Khoshdooz Sara , Kalantari Naser , Azizi Tabesh Ghasem , Doaei Saeid , Gholamalizadeh Maryam 
Published: April 2024

ABSTRACTBackgroundThe FTO gene polymorphisms may influence the effects of lifestyle interventions on obesity. The present study aimed to assess the influence of the rs9930506 FTO gene polymorphism on the success of a comprehensive weight loss intervention in male adolescents with overweight and obesity.MethodsThis study was carried out on 96 adolescent boys with overweight and obesity who were randomly assigned to the intervention (n = 53) and control (n = 43) groups. The blood samples of the participants were collected, and the FTO gene was genotyped for the rs9930506 polymorphism. A comprehensive lifestyle intervention including changes in diet and physical activity was performed for 8 weeks in the intervention group.ResultsFollowing the lifestyle intervention, BMI and fat mass decreased significantly in the intervention group compared with the control group (both p < 0.05), while no change was found in weight, height or body muscle percentage between the groups. The participants in the intervention group with the AA/AG genotype and not in carriers of the GG genotype had a significantly higher reduction in BMI (−1.21 vs. 1.87 kg/m2, F = 4.07, p < 0.05) compared with the control group.ConclusionThe intervention in individuals with the AA/AG genotype has been significantly effective in weight loss compared with the control group. The intervention had no association effect on anthropometric indices in adolescents with the GG genotype of the FTO rs9930506 polymorphism.Trial RegistrationName of the registry: National Nutrition and Food Technology Research Institute; Trial registration number: IRCT2016020925699N2; Date of registration: 24/04/2016; URL of trial registry record: https://www.irct.ir/trial/21447
Body mass index and cardiorenal outcomes in the EMPEROR‐Preserved trial: Principal findings and meta‐analysis with the DELIVER trial
Authors: Sattar Naveed , Butler Javed , Lee Matthew M.Y. , Harrington Josephine , Sharma Abhinav , Zannad Faiez , Filippatos Gerasimos , Verma Subodh , Januzzi James L. , Ferreira João Pedro , Pocock Stuart J. , Pfarr Egon , Ofstad Anne P. , Brueckmann Martina , Packer Milton , Anker Stefan D. 
Published: April 2024

AbstractAimsBoth low and high body mass index (BMI) are associated with poor heart failure outcomes. Whether BMI modifies benefits of sodium–glucose cotransporter 2 inhibitors (SGLT2i) in heart failure with preserved ejection fraction (HFpEF) requires further investigation.Methods and resultsUsing EMPEROR‐Preserved data, the effects of empagliflozin versus placebo on the risks for the primary outcome (hospitalization for heart failure [HHF] or cardiovascular [CV] death), change in estimated glomerular filtration rate (eGFR) slopes, change in Kansas City Cardiomyopathy Questionnaire clinical summary score (KCCQ‐CSS), and secondary outcomes across baseline BMI categories (<25 kg/m2, 25 to <30 kg/m2, 30 to <35 kg/m2, 35 to <40 kg/m2 and ≥40 kg/m2) were examined, and a meta‐analysis conducted with DELIVER. Forty‐five percent had a BMI of ≥30 kg/m2. For the primary outcome, there was a consistent treatment effect of empagliflozin versus placebo across the BMI categories with no formal interaction (p trend = 0.19) by BMI categories. There was also no difference in the effects on secondary outcomes including total HHF (p trend = 0.19), CV death (p trend = 0.20), or eGFR slope with slower declines with empagliflozin regardless of BMI (range 1.12–1.71 ml/min/1.73 m2 relative to placebo, p trend = 0.85 for interaction), though there was no overall impact on the composite renal endpoint. The difference in weight change between empagliflozin and placebo was −0.59, −1.48, −1.54, −0.87, and − 2.67 kg in the lowest to highest BMI categories (p trend = 0.016 for interaction). A meta‐analysis of data from EMPEROR‐Preserved and DELIVER showed a consistent effect of SGLT2i versus placebo across BMI categories for the outcome of HHF or CV death. There was a trend toward greater absolute KCCQ‐CSS benefit at 32 weeks with empagliflozin at higher BMIs (p = 0.08).ConclusionsEmpagliflozin treatment resulted in broadly consistent cardiac effects across the range of BMI in patients with HFpEF. SGLT2i treatment yields benefit in patients with HFpEF regardless of baseline BMI.
Stable overexpression of native and artificial miRNAs for the production of differentially fucosylated antibodies in CHO cells
Authors: Schlossbauer Patrick , Naumann Lukas , Klingler Florian , Burkhart Madina , Handrick René , Korff Kathrin , Neusüß Christian , Otte Kerstin , Hesse Friedemann 
Published: April 2024

AbstractCell engineering strategies typically rely on energy‐consuming overexpression of genes or radical gene‐knock out. Both strategies are not particularly convenient for the generation of slightly modulated phenotypes, as needed in biosimilar development of for example differentially fucosylated monoclonal antibodies (mAbs). Recently, transiently transfected small noncoding microRNAs (miRNAs), known to be regulators of entire gene networks, have emerged as potent fucosylation modulators in Chinese hamster ovary (CHO) production cells. Here, we demonstrate the applicability of stable miRNA overexpression in CHO production cells to adjust the fucosylation pattern of mAbs as a model phenotype. For this purpose, we applied a miRNA chaining strategy to achieve adjustability of fucosylation in stable cell pools. In addition, we were able to implement recently developed artificial miRNAs (amiRNAs) based on native miRNA sequences into a stable CHO expression system to even further fine‐tune fucosylation regulation. Our results demonstrate the potential of miRNAs as a versatile tool to control mAb fucosylation in CHO production cells without adverse side effects on important process parameters.
Potassium channel‐related epilepsy: Pathogenesis and clinical features
Authors: Zhao Tong , Wang Le , Chen Fang 
Published: April 2024

AbstractVariants in potassium channel‐related genes are one of the most important mechanisms underlying abnormal neuronal excitation and disturbances in the cellular resting membrane potential. These variants can cause different forms of epilepsy, which can seriously affect the physical and mental health of patients, especially those with refractory epilepsy or status epilepticus, which are common among pediatric patients and are potentially life‐threatening. Variants in potassium ion channel‐related genes have been reported in few studies; however, to our knowledge, no systematic review has been published. This study aimed to summarize the epilepsy phenotypes, functional studies, and pharmacological advances associated with different potassium channel gene variants to assist clinical practitioners and drug development teams to develop evidence‐based medicine and guide research strategies. PubMed and Google Scholar were searched for relevant literature on potassium channel‐related epilepsy reported in the past 5–10 years. Various common potassium ion channel gene variants can lead to heterogeneous epilepsy phenotypes, and functional effects can result from gene deletions and compound effects. Administration of select anti‐seizure medications is the primary treatment for this type of epilepsy. Most patients are refractory to anti‐seizure medications, and some novel anti‐seizure medications have been found to improve seizures. Use of targeted drugs to correct aberrant channel function based on the type of potassium channel gene variant can be used as an evidence‐based pathway to achieve precise and individualized treatment for children with epilepsy.Plain Language SummaryIn this article, the pathogenesis and clinical characteristics of epilepsy caused by different types of potassium channel gene variants are reviewed in the light of the latest research literature at home and abroad, with the expectation of providing a certain theoretical basis for the diagnosis and treatment of children with this type of disease.
CFD modeling of a triple‐walled direct absorption evacuated tube solar collector based on hybrid nanofluid/microencapsulated PCM
Authors: Shahini Niloofar , Karami Maryam , Akhavan‐Behabadi Mohammad Ali 
Published: April 2024

AbstractNowadays, direct absorption solar collectors are a new concept of solar collectors which have attracted special attention. The type of heat transfer fluid (HTF) has a significant influence on the efficiency of this kind of collector. Therefore, in this study, a wide range of working fluids including mono nanofluid ( and CuO), binary nanofluid, and especially the incorporation of a new hybrid combination of nanofluid and microencapsulated phase change material (MPCM), are used as the working fluids of a triple‐walled direct absorption evacuated tube solar collector. The computational fluid dynamics (CFD) method is used for simulating the collector and investigating the effect of different parameters including volume fraction, base fluid, mass flow rate, and type of absorber tube structure (double‐ and triple‐walled) on collector thermal performance. Results show that binary nanofluids of 0.06% /0.002% CuO/water and 0.06% /0.002% CuO/ethylene glycol (EG) have the largest working fluid temperature differentials equal to 48.31 and 66.5 K, respectively. It was inferred that, at the mass flow rate of 2.7 , the efficiency is obtained to be 60.29% employing binary/EG nanofluid, which is 8.68% and 15.31% higher than CuO/EG and /EG nanofluids, respectively. Inserting the hybrid CuO nanofluid/MPCM leads to an improvement of 1.14% and 1.22% in the efficiency of triple‐ and double‐walled collectors, respectively, with respect to the individual usage of the nanofluid. The thermal efficiency of the double‐walled structure is higher than triple‐walled considering all HTFs.
Occurrence of Pharmaceutical Micropollutants in Lake Nahuel Huapi, Argentine Patagonia
Authors: Beamud Sara Guadalupe , Fernández Horacio , Nichela Daniela , Crego Maria Paula , Gonzalez-Polo Marina , Latini Lorena , Aguiar María Belén , Diblasi Lorena , Parolo María Eugenia , Temporetti Pedro 
Published: April 2024

Abstract
Tourism is one of the most important activities for the economy of Nor Patagonia Argentina. In Bariloche City, located on the shores of Lake Nahuel Huapi, both the permanent and the temporary populations have increased significantly in recent decades, and this has not necessarily been accompanied by an improvement in sewage networks. Emerging micropollutants such as pharmaceutical compounds reach aquatic systems directly, in the absence of a domestic sewage network, or through effluents from wastewater treatment plants (WWTP), which do not efficiently remove these substances and represent a major threat to the environment. Therefore, the objective of our study was to monitor the presence of pharmaceutical compounds discharged both through wastewater effluents and diffusely from housing developments into Lake Nahuel Huapi. The results obtained demonstrate the presence of pharmaceuticals in Lake Nahuel Huapi with concentrations ranging from not detectable (ND) to 110.6 ng L–1 (caffeine). The highest pharmaceutical concentration recorded in WWTP influent corresponded to caffeine (41728 ng L–1), and the lowest concentration was paracetamol (18.8 ng L–1). The removal efficiency of pharmaceuticals in the WWTP was calculated, and ranged from 0% for carbamazepine to 66% for ciprofloxacin. This antibiotic showed the lowest % of attenuation (73%) in Lake Nahuel Huapi. These results on the occurrence of a wide variety of pharmaceuticals are the first generated in Patagonia, representing a regional baseline for this type of micropollutant and valuable information for the subsequent design of removal strategies for emerging pharmaceutical pollutants in surface water. Environ Toxicol Chem 2024;43:1274–1284. © 2024 SETAC
Volumetric heating and AC electric field effects on porous convection with general boundary conditions
Authors: Rachitha Chowlahiriyur Shivappa , Nanjundappa Chikkanalluru Erappa , Shivakumara Inapura Siddagangaiah 
Published: April 2024

AbstractThe onset of convective instability in an internally heated dielectric fluid‐saturated porous layer under the influence of a uniform AC electric field for different types of boundary conditions is investigated. The flow in the porous medium is described by the Brinkman model with fluid viscosity different from effective viscosity. The lower adiabatic and the top with finite heat transfer coefficient to the external environment boundaries are considered to be either rigid or stress‐free. The presence of a uniform volumetric heat source alters the conduction profile of the temperature field from linear to quadratic in the vertical coordinate. A modal linear stability analysis of the basic motionless state is carried out and the general regime of linear instability is investigated by solving the stability eigenvalue problem numerically using the Galerkin method of weighted residual technique. The neutral stability condition as well as the critical value of the thermal Rayleigh number is computed for rigid–rigid, free–free, and rigid–free boundaries for various values of governing parameters. It is seen that the nature of boundaries affect the stability of the system only quantitatively, though not qualitatively. The rigid–rigid boundaries offer a more stabilizing effect against convection in comparison with rigid–free and free–free boundaries. The study found that the effect of increasing thermal electric Rayleigh number and the Darcy number is to hasten the onset of instability, while the opposite trend is perceived with an increase in the ratio of viscosities and Biot number. The outcomes of this investigation are found to be in good agreement with past studies under the limiting cases.
The dental COVID‐19 paradox: Disparity in behaviors inside and outside dental schools in Canada
Authors: Steinberg Noam , Batistella Elis Angela , Iyer Srimathi , Madathil Sreenath Arekunnath , Allison Paul , Brondani Mario , Glogauer Michael , Levin Liran 
Published: April 2024

AbstractObjectiveTo describe the personal and professional behavior and assess the perceptions of protection and fear of contracting coronavirus disease 2019 (COVID‐19) among faculty, staff, and students from all 10 Canadian dental schools during the second year of the pandemic.MethodParticipants from a Pan‐Canadian prospective study answered monthly questionnaires about their activities between April 2021 and March 2022. In May 2022, additional questions were asked about their perception of protection, fear of infection, and instances of COVID‐19 testing.ResultsSix hundred participants were initially recruited. Over time, the participants spent less time at home and increased their participation in indoor social activities, a trend influenced by the fluctuations in COVID‐19 cases (β = ‒0.02). Over 90% of the participants were fully vaccinated, which decreased their fear of contracting the virus (χ2[4, 241‒243] = 196.07, p < 0.0001). Yet, their attitude toward protective measures did not change, and they followed them within school.ConclusionsThis work shows a paradoxical behavior among dental students, staff, and faculty members in Canadian dental schools. While factors such as the vaccine's limited efficacy and a desire to protect others may contribute to stringent protective behaviors within dental schools, the mandatory nature of these measures was likely the primary motivator for the compliance. Despite potential efforts to minimize exposure to the virus during risk periods and the frequent COVID‐19 testing, this paradoxical behavior raises questions about professional responsibilities extending beyond the workplace. Thus, dental schools should incorporate education about the rationale behind following different protocols and the potential consequences of outside school behaviors.