bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thoracoabdominalis aneurysma hybrid megoldásar
Authors: Dzsinich Csaba , Hüttl Kálmán , Cavarra Gaetano , Dzsinich Máté 
Published: April 2008

Absztrakt
Az endograftok az aortaaneurysmák sebészi kezelésének lehetőségeit kiszélesítették, alkalmazzák őket az aortaív és a thoracoabdominalis aorta tágulatainak megoldására is. A nagy mellékágak keringését az endograftbeültetés előtt biztosítani kell. Az utóbbi években tapasztalatot szereztünk az aortaív aneurysmáinak hybrid kezelésével. 2007 januárjában egy 79 éves nőbetegnél thoracoabdominalis hybrid műtétre vállalkoztunk. A Crawford IV. típusú aortaaneurysma felső hasi fájdalmat okozott, átmérője 60 mm volt, és 80 mm-es aortaszakaszt érintett, involválta a truncus coeliacus szájadékát is. Megfelelő distalis rögzítési zóna kialakítására szükségessé vált a truncus coeliacus lekötése és keringésének extraanatomicus helyreállítása. Az aorta infrarenalis szakaszáról 8 mm-es PTFE graftot vezettünk antepancreaticus úton az arteria lienalisra. Ezután a truncus coeliacust az aorta szintjében elvarrtuk. Az arteria lienalison át a coeliaca valamennyi ága megfelelő keringéshez jutott. A lép vérellátását a gastroepiploicus arteria biztosította. Négy nappal később a bal arteria femoralison át 34 mm átmérőjű 15 cm hosszú Thoracic excludert vezettünk a thoracoabdominalis aortába és lefedtük az aneurysmát. A distalis rögzítőpont az a. mesenterica szájadékáig ért. A beavatkozást a beteg jól viselte, sebei pp gyógyultak, panaszmentesen távozott. A 12 hónappal később végzett CT-vizsgálat jó coeliacakeringést és az aneurysma involutióját bizonyította. A beteg panaszmentes. Hazánkban ez volt az első thoracoabdominalis hybrid műtét.
Primer vékonybél T-sejtes lymphoma operált eseter
Authors: Alzubi Ali , Zöllei István , Krenács László , Intzédy Katalin , Hudák János 
Published: April 2008

AbsztraktA vékonybelek elsődleges rosszindulatú daganatai ritkák. Jelenleg még nem áll rendelkezésre specifikus vizsgálati módszer, amely biztosítaná ezen betegség korai felismerését. A szerzők egy diagnosztikai nehézséget okozó primer vékonybél T-sejtes lymphoma esetét mutatják be egy 66 éves nőbetegük kapcsán, aki hasi panaszok, tapintható hasi terime miatt került kivizsgálásra. A műtét előtti labor-, endoscopos, hasi UH- és CT-vizsgálatok nem vezettek pontos diagnózishoz. A gyomor-bél passage-vizsgálat viszont leírt egy belső vékonybélfistulát, de az eredetét nem tudta tisztázni. Ezt követően történt a hasűri exploratio, amelynek során az észlelt tumor, a belső fistulával együtt, eltávolításra került. A szövettani vizsgálat primer vékonybél T-sejtes lymphomát igazolt. E lelet birtokában indult a haematologiai kezelés. Három hónappal később multiplex áttétek jelentek meg a beteg tüdejében. A vékonybéltumorok felismerése még napjainkban is nehézséget okoz. A diagnózis felállítása és a megfelelő kezelés megkezdése emiatt sokszor késik. A jövőben a kapszulás endoscopia vizsgálat pontosíthatja a műtét előtti diagnózist, azonban e kórkép szövettani verifikáláshoz és kezeléséhez a sebészi feltárás továbbra is elengedhetetlen.
A posztoperatív mesenterialis panniculitisről egy sikerrel kezelt eset kapcsánr
Authors: Bognár Gábor , Forgács Bence , István Gábor , Bereczky Bíborka , Berczi Lajos , Ledniczky György , Ondrejka Pál 
Published: April 2008

Absztrakt
A mesenterialis panniculitis minden hasi műtéten átesett beteget érinthet. A betegség klinikai és patológiai képe nem egységes, ennek megfelelően a terápiája is más a különböző stádiumaiban. E stádiumokat egyesek vitatják, és egy betegség különféle manifesztációinak tartják őket, míg mások folyamatában látják a betegség kialakulását. Egy 65 éves férfi betegünknél két ízben alakult ki posztoperatív fibrotisáló, meseneterialis panniculitis. Az első alkalommal laparoscopos sigmaresectiót követően észleltük a teljes mesosigmát érintő folyamatot. Az ekkor végzett Hartmann-műtét után, a tervezett vastagbél-rekonstrukciót követően másodszor is kialakult a betegség, mely ekkor a teljes mesenteriumot és a mesocolon-lemezeket involválta. Az exploratio során sebészi intervenció nem volt kivitelezhető. A beteg antibiotikum, steroid, tartós parenteralis táplálás és nasogastricus szonda mellett 3 hét alatt meggyógyult. Konzervatív sikerrel kezelt esetünk kapcsán ismertetjük e sokarcú betegséget és a kezelés lehetőségeit.
Tunable Crystal Nanostructures of Pentacene Thin Films on Gate Dielectrics Possessing Surface‐Order Control
Authors: Kim Do Hwan , Lee Hwa Sung , Yang Hoichang , Yang Lin , Cho Kilwon 
Published: April 2008

AbstractTo enhance the electrical performance of pentacene‐based field‐effect transistors (FETs) by tuning the surface‐induced ordering of pentacene crystals, we controlled the physical interactions at the semiconductor/gate dielectric (SiO2) interface by inserting a hydrophobic self‐assembled monolayer (SAM, CH3‐terminal) of organoalkyl‐silanes with an alkyl chain length of C8, C12, C16, or C18, as a complementary interlayer. We found that, depending on the physical structure of the dielectric surfaces, which was found to depend on the alkyl chain length of the SAM (ordered for C18 and disordered for C8), the pentacene nano‐layers in contact with the SAM could adopt two competing crystalline phases—a “thin‐film phase” and “bulk phase” – which affected the π‐conjugated nanostructures in the ultrathin and subsequently thick films. The field‐effect mobilities of the FET devices varied by more than a factor of 3 depending on the alkyl chain length of the SAM, reaching values as high as 0.6 cm2 V−1 s−1 for the disordered SAM‐treated SiO2 gate‐dielectric. This remarkable change in device performance can be explained by the production of well π‐conjugated and large crystal grains in the pentacene nanolayers formed on a disordered SAM surface. The enhanced electrical properties observed for systems with disordered SAMs can be attributed to the surfaces of these SAMs having fewer nucleation sites and a higher lateral diffusion rate of the first seeding pentacene molecules on the dielectric surfaces, due to the disordered and more mobile surface state of the short alkyl SAM.
Congenital factor X deficiencies with a defect only or predominantly in the extrinsic or in the intrinsic system: A critical evaluation
Authors: Girolami Antonio , Scarparo Pamela , Scandellari Raffaella , Allemand Emanuele 
Published: April 2008

AbstractCongenital Factor X deficiency is commonly classified as type I, in which there is a concomitant decrease of activity and antigen (CRM negative), and in type II, in which activity is low but antigen is normal or near normal (CRM positive). During the past decades it was shown that type II was by itself very heterogeneous. It was shown in fact that some forms showed a defect in all three assay systems (extrinsic, intrinsic, and RVV dependent), whereas others showed a defect only in two of the three systems. Molecular biology analysis, whenever available, has failed so far to supply clear explanations for these discrepancies. The purpose of the present article was an attempt to correlate the clotting activities seen in these two defects with other clotting, chromogenic, immunological assays, and molecular biology results. There are in the literature 10 families that show a predominant defect in the extrinsic system, and four families that show a predominant defect in the intrinsic system. All patients showed a normal, near normal, or reduced level of antigen that is always definitively higher than the clotting counterpart. Molecular biology studies revealed mutations in different exons, namely 2, 4, 5, 6, and 8. These mutations in different exons do not allow any clear genotype‐phenotype conclusions, but indicate that mutations in different exons may give rise to the same phenotype. The study underlines the importance of a multipronged evaluation of all cases with Factor X deficiency. In fact only by this approach can an acceptable classification of the defect be reached. Am. J. Hematol., 2008. © 2008 Wiley‐Liss, Inc.
A myeloablative conditioning regimen for patients with impaired cardiac function undergoing allogeneic stem cell transplantation: Reduced cyclophosphamide combined with etoposide and total body irradiation
Authors: Yoshimi Akihide , Nannya Yasuhito , Sakata‐Yanagimoto Mamiko , Oshima Kumi , Takahashi Tsuyoshi , Kanda Yoshinobu , Motokura Toru , Chiba Shigeru , Kurokawa Mineo 
Published: April 2008

AbstractTo circumvent the cardiac toxicity of high‐dose cyclophosphamide (CY) in the myeloablative conditioning for those with cardiac comorbidity, we developed a new cardiac sparing conditioning regimen (VP/rCY/TBI) composed of 12 Gy of total body irradiation (TBI), etoposide (VP‐16) (40 mg/kg), and reduced CY (40 mg/kg). We assessed the feasibility of this regimen by retrospectively comparing the outcome of VP/rCY/TBI recipients (n = 18) with that of CY/TBI recipients (n = 140). VP/rCY/TBI recipients had significantly higher cumulative dose of anthracyclines, lower ejection fraction (EF), and poorer Karnofsky performance scales (KPS) than CY/TBI recipients. The cumulative incidences of disease progression were 34.9% in VP/rCY/TBI recipients and 19.0% in CY/TBI recipients (P = 0.33). Despite poorer KPS and more cardiac comorbidity in the VP/rCY/TBI recipients, no difference in the nonprogression mortality rates was observed among recipients of the two regimens (17.5 and 14.3%, respectively, P = 0.96). Severe cardiac toxicity within 28 days after transplantation occurred in 5.9 and 3.6% of VP/rCY/TBI and CY/TBI recipients, respectively (P = 0.64). Graft rejection was not observed in VP/rCY/TBI recipients. There is a possibility that VP/rCY/TBI regimen can be safely administered for patients with pretransplantation cardiac comorbidity while preserving antineoplastic effects. These observations merit further prospective study. Am. J. Hematol., 2008. © 2008 Wiley‐Liss, Inc.
How Is Oxygen Incorporated into Oxides? A Comprehensive Kinetic Study of a Simple Solid‐State Reaction with SrTiO3 as a Model Material
Authors: Merkle Rotraut , Maier Joachim 
Published: April 2008

AbstractThe kinetics of stoichiometry change of an oxide—a prototype of a simple solid‐state reaction and a process of substantial technological relevance—is studied and analyzed in great detail. Oxygen incorporation into strontium titanate was chosen as a model process. The complete reaction can be phenomenologically and mechanistically understood beginning with the surface reaction and ending with the transport in the perovskite. Key elements are a detailed knowledge of the defect chemistry of the perovskite as well as the application of a variety of experimental and theoretical tools, many of them evolving from this study. The importance of the reaction and transport steps for (electro)chemical applications is emphasized.
Mechanical and water sorption studies of ecofriendly banana fiber‐reinforced polyester composites fabricated by RTM
Authors: Sreekumar P. A , Albert Pradeesh , Unnikrishnan G. , Joseph Kuruvilla , Thomas Sabu 
Published: April 2008

AbstractBanana fiber, one of the world's most important natural fiber obtained from the bast of the plant Musa Saptentum Linn, is available in plenty in Kerala. Without reinforcement, polyester resins are hard and brittle and cannot be used for structural applications. In the present study, short banana fiber‐reinforced polyester composite materials have been fabricated using resin transfer molding technique. Mechanical properties such as tensile, flexural, and impact strength were studied as a function of fiber length and fiber content. It is seen that the addition of fibers makes the composite more ductile. The composites having fiber length of 30 mm and a fiber content of 40 vol % showed the maximum tensile strength. Flexural strength and impact properties showed similar trend. Scanning electron microscopy was performed to get an insight into the morphology of the composites. Water absorption study proved that fiber content and temperature conditions influences the diffusion of water into the composite. The composite having a fiber content of 50 vol % showed maximum values for diffusion, sorption, and permeability coefficient. Finally, the mechanical properties and water absorption behavior of the composites fabricated by RTM were compared with theoretical predictions. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2008
Age‐Related Changes in Bone‐Strength‐Associated Geometry Indices in Naive Human Population
Authors: Kalichman Leonid , Malkin Ida , Bigman Galya , Matias Rakefet , Seibel Markus J. , Kobyliansky Eugene , Livshits Gregory 
Published: April 2008

AbstractThe aim of the present study was to evaluate age‐ and sex‐related changes in the geometry parameters (metacarpal cortical index (MCI) and Breaking Bending Resistance Index [BBRI]) of long hand bones in a large Chuvashian cohort using cross‐sectional and longitudinal study designs. The data were gathered in 1994 (557 individuals) and 2002 (513 individuals). The latter sample included 260 individuals who were studied only during the second expedition, and 253 individuals who were previously investigated in 1994. Statistical analyses included a maximum likelihood‐based model‐fitting technique and a t‐test comparison. Our study describes age‐related MCI and BBRI changes in both sexes from the age of 18 years to 84 years. At any age, the BBRI values were higher in males than in females, but MCI was greater in females than in males before age 50 and lower after that age. The study provides initial evidence of a secular trend in MCI and BBRI. In male hand bones, the cortex became relatively thicker and it better resisted bending and breaking in comparison to individuals born at the beginning of the 20th century. In females, the trend toward higher MCI values can be observed only in those born between 1936 and 1966 and the trend toward higher BBRI values stopped in 1950. Anat Rec, 291:835‐844, 2008. © 2008 Wiley‐Liss, Inc.
Regulation of mitochondrial dynamics – characterization of fusion and fission genes in the ascomycete Podospora anserina
Authors: Scheckhuber Christian Q. , Rödel Elfie , Wüstehube Joycelyn 
Published: April 2008

AbstractThe filamentous ascomycete Podospora anserina is a model system for studying aging, a complex process that is regulated by multiple factors. Among these, mitochondria were shown to be of crucial importance. Recently, it was shown that the morphology of these organelles, which is dependent on dynamic fusion and fission processes, has profound effects on P. anserina aging. To further analyze this phenomenon, we characterized molecular components of the machinery regulating the dynamic behavior of mitochondria by utilizing transgenic strains in which fission genes (PaDnm1, PaFis1 and PaMdv1) and a fusion gene (PaFzo1) are overexpressed. While overexpression of PaFis1 has no phenotypic effects in the genetic background of the wild type, it surprisingly promotes mitochondrial fusion and decreases the life span in a mutant overexpressing PaDnm1. Remarkably, when grown on synthetic medium, overexpression of PaDnm1 leads to a decreased life span compared to the wild type. Increased expression of PaMdv1 results in the formation of ring‐shaped mitochondria, a morphology of these organelles that has not been previously observed in P. anserina. Transformants with elevated PaFzo1 transcript levels show no altered life span, although the age‐dependent fragmentation of mitochondria is impaired.
Investigation toward multi‐epitope vaccine candidates using native chemical ligation
Authors: Fujita Yoshio , Moyle Peter M. , Hieu Suzanne , Simerska Pavla , Toth Istvan 
Published: April 2008

AbstractWe applied native chemical ligation (NCL) method to the synthesis of highly pure lipid‐core peptide (LCP) vaccines to attach various peptide epitopes. In the case of the synthesis of LCP vaccine with two different peptide epitopes, LCP moieties having two free Cys and two protected Cys derivatives (S‐acetamidemethyl‐Cys, (Cys(Acm)), N‐methylsulfonylethyloxycarbonyl‐Cys (Msc‐Cys), or 1,3‐thiazolidine‐4‐carboxylic acid (Thz)) on oligolysine branches were prepared in order to couple two different epitopes by stepwise NCL. It was found that the difficulty in NCL of first two peptide antigen was associated with the steric hindrance. Using Thz instead of Cys(Acm) and Msc‐Cys was important to reduce the steric hindrance and improve NCL yield. © 2008 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 90: 624–632, 2008.This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com
Structural insights for designed alanine‐rich helices: Comparing NMR helicity measures and conformational ensembles from molecular dynamics simulation
Authors: Song Kun , Stewart James M. , Fesinmeyer R. Matthew , Andersen Niels H. , Simmerling Carlos 
Published: April 2008

AbstractThe temperature dependence of helical propensities for the peptides Ac‐ZGG‐(KAAAA)3X‐NH2 (Z = Y or G, X = A, K, and D‐Arg) were studied both experimentally and by MD simulations. Good agreement is observed in both the absolute helical propensities as well as relative helical content along the sequence; the global minimum on the calculated free energy landscape corresponds to a single α‐helical conformation running from K4 to A18 with some terminal fraying, particularly at the C‐terminus. Energy component analysis shows that the single helix state has favorable intramolecular electrostatic energy due to hydrogen bonds, and that less‐favorable two‐helix globular states have favorable solvation energy. The central lysine residues do not appear to increase helicity; however, both experimental and simulation studies show increasing helicity in the series X = Ala → Lys → D‐Arg. This C‐capping preference was also experimentally confirmed in Ac‐(KAAAA)3X‐GY‐NH2 and (KAAAA)3X‐GY‐NH2 sequences. The roles of the C‐capping groups, and of lysines throughout the sequence, in the MD‐derived ensembles are analyzed in detail. © 2008 Wiley Periodicals, Inc. Biopolymers 89: 747–760, 2008.This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com
A novel approach for calculating starch crystallinity and its correlation with double helix content: A combined XRD and NMR study
Authors: Lopez‐Rubio Amparo , Flanagan Bernadine M. , Gilbert Elliot P. , Gidley Michael J. 
Published: April 2008

AbstractA peak fitting procedure has been implemented for calculating crystallinity in granular starches. This methodology, widely used for synthetic polymers, is proposed to better reflect the crystalline content of starches than the method normally used, in which it is assumed that relatively perfect crystalline domains are interspersed with amorphous regions. The new approach takes into account irregularities in crystals that are expected to exist in semicrystalline materials. Therefore, instead of assuming that the amorphous background extends up to the base of diffraction peaks, the whole X‐ray diffraction (XRD) profile is fitted to an amorphous halo and several discrete crystalline diffraction peaks. The crystallinity values obtained from the XRD patterns of a wide range of native starches using this fitting technique are very similar to the double helix contents as measured by 13C solid state NMR, suggesting that double helices in granular starches are present within irregular crystals. This contrasts with previous descriptions of crystalline and noncrystalline double helices that were based on the analysis of XRD profiles as perfect crystals interspersed in a noncrystalline background. Furthermore, with this fitting methodology it is possible to calculate the contribution from the different crystal polymorphs of starch to the total crystallinity. © 2008 Wiley Periodicals, Inc. Biopolymers 89: 761–768, 2008.This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com
Refining the course of the thoracolumbar nerves: A new understanding of the innervation of the anterior abdominal wall
Authors: Rozen W.M. , Tran T.M.N. , Ashton M.W. , Barrington M.J. , Ivanusic J.J. , Taylor G.I. 
Published: April 2008

AbstractPrevious descriptions of the thoracolumbar spinal nerves innervating the anterior abdominal wall have been inconsistent. With modern surgical and anesthetic techniques that involve or may damage these nerves, an improved understanding of the precise course and variability of this anatomy has become increasingly important. The course of the nerves of the anterior abdominal is described based on a thorough cadaveric study and review of the literature. Twenty human cadaveric hemi‐abdominal walls were dissected to map the course of the nerves of the anterior abdominal wall. Dissection included a comprehensive tracing of nerves and their branches from their origins in five specimens. The branching pattern and course of all nerves identified were described. All thoracolumbar nerves that innervate the anterior abdominal wall were found to travel as multiple mixed segmental nerves, which branch and communicate widely within the transversus abdominis plane (TAP). This communication may occur at multiple locations, including large branch communications anterolaterally (intercostal plexus), and in plexuses that run with the deep circumflex iliac artery (DCIA) (TAP plexus) and the deep inferior epigastric artery (DIEA) (rectus sheath plexus). Rectus abdominis muscle is innervated by segments T6‐L1, with a constant branch from L1. The umbilicus is always innervated by a branch of T10. As such, identification or damage to individual nerves in the TAP or within rectus sheath is unlikely to involve single segmental nerves. An understanding of this anatomy may contribute to explaining clinical outcomes and preventing complications, following TAP blocks for anesthesia and DIEA perforator flaps for breast reconstruction. Clin. Anat. 21:325–333, 2008. © 2008 Wiley‐Liss, Inc.
Estimation of the number and size of motor units in intrinsic laryngeal muscles using morphometric methods
Authors: Neto Humberto Santo , Marques Maria Júlia 
Published: April 2008

AbstractThe number and size of motor units in the intrinsic laryngeal muscles were estimated by morphometric methods. Laryngeal muscles with their respective nerve branches were obtained from 64 fresh cadavers (32 older than 60 years, mean age 74 ± 9 years and 32 younger than 60 years, mean age 51 ± 8 years). Myelinated nerve fibers and the total number of muscle fibers were counted. Motor unit size was estimated by dividing the total number of muscle fibers by the total number of motor units in each case. The mean number of motor units ranged from 268 ± 1.3 (interarytenoid muscle) to 431 ± 1.6 (cricothyroid muscle). Thyroarytenoid and cricothyroid muscle presented the smallest (9.8 ± 0.2) and largest (20.5 ± 0.9) motor unit size, respectively, suggesting that thyroarytenoid muscle has a greater capacity to fine‐tune its total force compared with the other intrinsic laryngeal muscles. No differences in motor unit number or size were observed between the right and left sides or between younger and older subjects. It is suggested that synaptic rearrangements may occur at the level of the neuromuscular junction in the human larynx that may explain the age‐related changes in motor units reported by clinical methods. Clin. Anat. 21:301–306, 2008. © 2008 Wiley‐Liss, Inc.