bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exposure to Polybrominated Diphenyl Ethers and Risk of All-Cause and Cause-Specific Mortality
Authors: Liu Buyun , Lehmler Hans-Joachim , Ye Ziyi , Yuan Xing , Yan Yuxiang , Ruan Yuntian , Wang Yi , Yang Yu , Chen Shuhan , Bao Wei 
Published: April 2024

ImportancePolybrominated diphenyl ethers (PBDEs) are an important group of persistent organic pollutants with endocrine-disrupting properties. However, prospective cohort studies regarding the association of PBDE exposure with long-term health outcomes, particularly mortality, are lacking.ObjectiveTo examine the association of environmental exposure to PBDEs with risk of all-cause and cause-specific mortality.Design, Setting, and ParticipantsThis nationally representative cohort study used data from the National Health and Nutrition Examination Survey 2003 to 2004 and linked mortality information through December 31, 2019. Adults aged 20 years or older with available data on PBDE measurements and mortality were included. Statistical analysis was performed from February 2022 to April 2023.ExposuresPBDE analytes in serum samples were measured using solid phase extraction and isotope dilution gas chromatography high-resolution mass spectrometry.Main Outcomes and MeasuresAll-cause mortality, cancer mortality, and cardiovascular mortality.ResultsThis study included 1100 participants (mean [SE] age, 42.9 [0.6] years; proportion [SE] female, 51.8% [1.6%]; proportion [SE] Hispanic, 12.9% [2.7%]; proportion [SE] non-Hispanic Black, 10.5% [1.6%]; proportion [SE] non-Hispanic White, 70.8% [3.7%]; proportion [SE] other race and ethnicity, 5.8% [1.1%]). During 16 162 person-years of follow-up (median [IQR] follow-up, 15.8 [15.2-16.3] years; maximum follow-up, 17 years), 199 deaths occurred. Participants with higher serum PBDE levels were at higher risk for death. After adjustment for age, sex, and race and ethnicity, lifestyle and socioeconomic factors, and body mass index, participants with the highest tertile of serum PBDE levels had an approximately 300% increased risk of cancer mortality (HR, 4.09 [95% CI, 1.71-9.79]) compared with those with the lowest tertile of serum PBDE levels. No significant association of PBDE exposure with all-cause mortality (HR, 1.43 [95% CI, 0.98-2.07]) or cardiovascular mortality (HR, 0.92 [95% CI, 0.41-2.08]) was observed.Conclusions and RelevanceIn this nationally representative cohort study, PBDE exposure was significantly associated with an increased risk of cancer mortality. Further studies are needed to replicate the findings and determine the underlying mechanisms.
Crafting Tunable Hollow Particles Using Antisolvent‐Driven Interlocking of Micron‐Sized Building Blocks
Authors: Li Peilong , Li Jieying , Levin Jacob , Kierulf Arkaye , Smoot James , Zarei Amin , Abbaspourrad Alireza 
Published: April 2024

AbstractThe contribution of a hollow structure on the rheological behavior of granular suspensions remains un‐investigated due to the challenge of water impermeability. Here starch is used to fabricate water‐permeable hollow particles, as a model for granular suspensions and investigated the resulting microstructures and rheological behavior. The hollow structure is fabricated based on a bottom‐up method by assembling micron‐sized building blocks into a superstructure. A Pickering emulsion is heated to fuse the starch interface, then, upon antisolvent precipitation, the polymer strands interlock to form a rigid shell around the oil template. When the template is removed a hollow particle remained. These particles exhibited a specific volume >5‐times higher than unmodified starch and consequently a higher viscosity. Larger particles showed higher viscosity but are also more fragile. The template structure can be manipulated to fine‐tune their functionality. These micro‐sized building blocks made from edible materials can be used as the next generation of texturizers. Additionally, these water‐permeable colloidosomes present an innovative approach to understanding how micro‐architectures impact the rheological behavior of granular suspensions.
Valence Engineering via Manganese‐Doping on Cobalt Nitride Nanoarrays for Efficient Electrochemically Paired Glycerol Valorization and H2 Production
Authors: Li Jiachun , Meng Xiangtong , Song Xuedan , Qi Jun , Liu Fei , Xiao Xue , Du Yadong , Xu Guangyao , Jiang Zhanhao , Ye Shenghua , Huang Shaoluan , Qiu Jieshan 
Published: March 2024

AbstractIntegration of more thermodynamically favorable valorization of biomass (e.g., glycerol), compared to sluggish oxygen evolution, with H2 production is of great significance for energy‐saving electrosynthesis of value‐added chemicals. However, its widespread deployment has been challenged by costly electrocatalysts and large overpotential reaching an industrial‐relevant current density (≥400 mA cm−2). Herein, carbon shell‐encapsulated manganese‐doped cobalt nitride nanoarrays immobilizing on nickel foam, denoted Mn‐CoN@C/NF, are crafted via hydrothermal method and ammoniation. As a bifunctional electrocatalyst, the Mn‐CoN@C/NF manifests extraordinary activity for glycerol oxidation reaction (GOR) with an ultralow potential of 1.37 V (versus RHE) at 400 mA cm−2, in conjunction with H2 evolution reaction (HER) with a low overpotential of 31 mV at 10 mA cm−2. A record high Faradaic efficiency (97.7%) for formate production of GOR is delivered at 1.35 V (vs RHE). Impressively, a two‐electrode electrolyzer capitalizing on the Mn‐CoN@C/NF as catalysts reaches 800 mA cm−2 at 1.83 V, delivering an electricity‐saving efficiency of 15.0% compared to pure water splitting. DFT calculations substantiate that Mn species within Mn‐CoN not only optimize hydrogen adsorption kinetics for HER, but also elevate Co3+ active sites’ density for GOR. This work offers an energy‐saving and efficient electrosynthesis avenue for coproduction of valuable chemicals.
Solvothermal Shaping of Imine‐Linked Covalent Organic Frameworks by a Two‐Step Solvent Feeding Process
Authors: Su Yajiao , Qin Molin , Kong Jinglin , Zhai Quanguo , Yuan Daqiang , Liu Zhongshan , Fang Yu 
Published: April 2024

AbstractSolvothermal synthesis is the predominant method for creating new structured covalent organic frameworks (COFs), yet it grapples with challenges in controlling shape and morphology. This issue is attributed to the unregulated solvent‐feeding process, which results in rapid polymerization and uncontrolled phase separation. Consequently, a two‐step solvent‐feeding process is reported for the solvothermal shaping of imine‐linked COF monoliths with hierarchical porosity. The synthesis conditions for COF powders reported in existing literature are directly utilized without extensive optimization; however, solvents are divided into two segments prior to feeding. A minor segment of solvents is employed to dissolve monomers, which polymerize in situ to form amorphous monoliths. Subsequently, the remaining organic solvent, along with an acetic acid aqueous solution, is added for crystallization. The versatility of this two‐step feeding process in producing COF monoliths is illustrated. The high‐quality COF monoliths demonstrate benzene uptakes ranging from 6.0 to 16.8 mmol g−1 at 298 K. This study confirms that the two‐step solvent feeding process can be effectively integrated with the conventional solvothermal method to enhance the solution‐processability of COFs. It is anticipated that this modified solvothermal approach can readily shape COFs to meet practical application requirements.
Calcium Peroxide‐Based Hydrogel Patch with Sustainable Oxygenation for Diabetic Wound Healing
Authors: Li Na , Lu Xiaohuan , Yang Yueying , Ning Shan , Tian Ye , Zhou Mengyuan , Wang Zheng , Wang Lin , Zang Jianfeng 
Published: April 2024

AbstractNonhealing diabetic wounds are predominantly attributed to the inhibition of angiogenesis, re‐epithelialization, and extracellular matrix (ECM) synthesis caused by hypoxia. Although oxygen therapy has demonstrated efficacy in promoting healing, its therapeutic impact remains suboptimal due to unsustainable oxygenation. Here, this work proposes an oxygen‐releasing hydrogel patch embedded with polyethylene glycol‐modified calcium peroxide microparticles, which sustainably releases oxygen for 7 days without requiring any supplementary conditions. The released oxygen effectively promotes cell migration and angiogenesis under hypoxic conditions as validated in vitro. The in vivo tests in diabetic mice models show that the sustainably released oxygen significantly facilitates the synthesis of ECM, induces angiogenesis, and decreases the expression of inflammatory cytokines, achieving a diabetic wound healing rate of 84.2% on day 7, outperforming the existing oxygen‐releasing approaches. Moreover, the proposed hydrogel patch is designed with porous, soft, antibacterial, biodegradable, and storage stability for 15 days. The proposed hydrogel patch is expected to be promising in clinics treating diabetic wounds.
Trichome‐Like Biomimetic Air Filters via Templated Silicone Nanofilaments
Authors: Zhou Zhiqiang , You Tianle , Pan Zhengyuan , Wang Di , Wang Hao , Wang Lingyun , Xu Guilong , Liang Yun , Hu Jian , Tang Min 
Published: April 2024

AbstractAir pollution threats to human health have increased awareness of the role of filter units in air cleaning applications. As an ideal energy‐saving strategy for air filters, the slip effect on nanofiber surfaces can potentially overcome the trade‐off between filtration efficiency and pressure drop. However, the potential of the slip effect in nanofibrous structures is significantly limited by the tight nanofiber stacks. In this study, trichome‐like biomimetic (TLB) air filters with 3D‐templated silicone nanofilaments (average diameter: ≈74 nm) are prepared based on an in situ chemical vapor deposition (CVD) method inspired by plant purification. Theoretical modeling and experimental results indicate that TLB air filters make significant use of the slip effect to overcome the efficiency‐resistance tradeoff. The selectable filter class (up to U15, ≈99.9995%) allows TLB air filters to meet various requirements, and their integral filtration performance surpasses that of most commodity air filters, including melt‐blown cloth, ePTFE membranes, electrospun mats, and glass fiber paper. The proposed strategy directly transforms commercial filter media and filters into TLB air filters using a bottom‐up, one‐step approach. As a proof‐of‐concept, reusable N95 respirators and air purifiers equipped with TLB air filters are fabricated, overcoming the limitations of existing filter designs and fabrication methods.
Mechanical Control of Quantum Transport in Graphene
Authors: McRae Andrew C. , Wei Guoqing , Huang Linxiang , Yigen Serap , Tayari Vahid , Champagne Alexandre R. 
Published: April 2024

Abstract2D materials (2DMs) are fundamentally electro‐mechanical systems. Their environment unavoidably strains them and modifies their quantum transport properties. For instance, a simple uniaxial strain can completely turn off the conductance of ballistic graphene or switch on/off the superconducting phase of magic‐angle bilayer graphene. This article reports measurements of quantum transport in strained graphene transistors which agree quantitatively with models based on mechanically‐induced gauge potentials. A scalar potential is mechanically induced in situ to modify graphene's work function by up to 25 meV. Mechanically generated vector potentials suppress the ballistic conductance of graphene by up to 30% and control its quantum interferences. The data are measured with a custom experimental platform able to precisely tune both the mechanics and electrostatics of suspended graphene transistors at low‐temperature over a broad range of strain (up to 2.6%). This work opens many opportunities to harness quantitative strain effects in 2DM quantum transport and technologies.
Two‐Terminal Perovskite Optoelectronic Synapse for Rapid Trained Neuromorphic Computation with High Accuracy
Authors: Guo Linqi , Sun Haoxuan , Min Liangliang , Wang Meng , Cao Fengren , Li Liang 
Published: March 2024

AbstractEmerging neural morphological vision sensors inspired by biological systems that integrate image perception, memory, and information computing are expected to transform the landscape of machine vision and artificial intelligence. However, stable and reconfigurable light‐induced synaptic behavior always relies on independent gateport modulation. Despite its potential, the limitations of uncontrollable defects and ionic characteristics have led to simpler, smaller, and more integration‐friendly two‐terminal devices being used as sidelines. In this work, the synergy between ion migration barriers and readout voltage is proven to be the key to realizing stable, reconfigurable, and precisely controllable postsynaptic current in two‐terminal devices. Following the same mechanism, optical and electrical signal synchronous triggering is proposed to serve as a preprocessing method to achieve a recognition accuracy of 96.5%. Impressively, the gradual ion accumulation during the training process induces photocurrent evolution, serving as a reference for the dynamic learning rate and boosting accuracy to 97.8% in just 10 epochs. The PSC modulation potential under short optical pulse of 20 ns is also revealed. This optoelectronic device with perception, memory, and computation capabilities can promote the development of new devices for future photonic neural morphological circuits and artificial vision.
Electrohydrodynamic Printing‐Based Heterointegration of Quantum Dots on Suspended Nanophotonic Cavities
Authors: Guymon Gregory G. , Sharp David , Cohen Theodore A. , Gibbs Stephen L. , Manna Arnab , Tzanetopoulos Eden , Gamelin Daniel R. , Majumdar Arka , MacKenzie J. Devin 
Published: March 2024

AbstractNanophotonic structures are a foundation for the growing field of light‐based quantum networks and devices enabled by their ability to couple with and manipulate photons. Colloidal quantum dots (QDs) are uniquely suited to complement this range of devices due to their solution‐processability, broad tuneability, and near‐unity photoluminescence quantum yields in some cases. To bridge the gap between them, electrohydrodynamic inkjet (EHDIJ) printing serves as a highly precise and scalable nanomanufacturing method for deterministic positioning and deposition of attoliter‐scale QD droplets. This includes heterointegration in devices that are challenging to create by conventional subtractive semiconductor processing, such as QDs emitters coupled to substrate‐decoupled nanoscale resonant structures. In this work, the first successful application of EHDIJ printing for the integration of these colloidal QDs into suspended nanophotonic cavities is demonstrated, achieving selective single‐cavity deposition for cavity pairs as close as 100 nm apart. These results motivate the development of future suspended hetero‐integrated devices that utilize EHDIJ printing as a sustainable, additive, and scalable method for quantum photonics nanomanufacturing.
Passivating Contacts for Crystalline Silicon Solar Cells: An Overview of the Current Advances and Future Perspectives
Authors: Li Wei , Xu Zhiyuan , Yan Yu , Zhou Jiakai , Huang Qian , Xu Shengzhi , Zhang Xiaodan , Zhao Ying , Hou Guofu 
Published: April 2024

AbstractSolar photovoltaics (PV) are poised to be crucial in limiting global warming by replacing traditional fossil fuel generation. Within the PV community, crystalline silicon (c‐Si) solar cells currently dominate, having made significant efficiency breakthroughs in recent years. These advancements are primarily due to innovations in solar cell technology, particularly in developing passivating contact schemes. As such, this review article comprehensively examines the evolution of high‐efficiency c‐Si solar cells, adopting a historical perspective to investigate the advancements in passivation contact techniques and materials to state‐of‐the‐art cell designs. Additionally, this work deeply studies the recent advances and critical design principles underlying each developed passivation scheme. Eventually, this work identifies existing challenges and proposes insights into future directions for c‐Si solar cells through diverse passivating contact strategies.
Prenatal findings in 11 cases with craniofacial microsomia using the Alberta Congenital Anomalies Surveillance System, 1997–2019
Authors: Thomas Mary Ann , Bedard Tanya , Crawford Susan , Lowry R. Brian 
Published: March 2024

AbstractCraniofacial microsomia (CFM) primarily includes specific head and neck anomalies that co‐occur more frequently than expected. The anomalies are usually asymmetric and affect craniofacial features; however, there are frequently additional anomalies of variable severity. Published prenatal findings for CFM are limited. This study contributes 11 cases with CFM and their anomalies identified prenatally. Cases born between January 1, 1997 and December 31, 2019 with CFM were abstracted from the Alberta Congenital Anomalies Surveillance System, which is a population‐based program ascertaining congenital anomalies for livebirths, stillbirths, and termination of pregnancies for fetal anomalies. There were 11 cases ascertained with prenatal findings including facial anomalies: one each with left cleft lip, right microtia, and bilateral microphthalmia. Two cases had vertebral anomalies. In addition, anomalies of the kidneys, brain, heart, and radial ray were identified. Six (55%) had a single umbilical artery, five (45%) were small for gestational age, and three (27%) were from a twin pregnancy that were discordant for anomalies. Four (36%) overlapped another proposed recurrent constellations of embryonic malformation condition. This study describes prenatal findings for 11 cases with CFM. Comparable to prior published cases, there were recurring anomalies on prenatal imaging, including anomalies of the brain, eye, heart, kidneys, and radial ray, which may aid in the prenatal diagnosis of CFM.
Update of the geographic range of Humboldt's squirrel monkeys (Saimiri cassiquiarensis cassiquiarensis Lesson, 1840) using a model‐based approach
Authors: Mourthé Ítalo , Paim Fernanda P. , Mercês Michelle P. , Valsecchi João , Rabelo Rafael M. 
Published: April 2024

AbstractSaimiri cassiquiarensis cassiquiarensis (Cebidae) is a primate subspecies with a wide distribution in the Amazonian region of Brazil, Colombia, and Venezuela. However, the boundaries of its geographic range remain poorly defined. This study presents new occurrence localities for this subspecies and updates its distribution using a compiled data set of 140 occurrence records based on literature, specimens vouchered in scientific collections, and new field data to produce model‐based range maps. After cleaning our data set, we updated the subspecies' extent of occurrence, which was used in model calibration. We then modeled the subspecies' range using a maximum entropy algorithm (MaxEnt). The final model was adjusted using a fixed threshold, and we revised this polygon based on known geographic barriers and parapatric congeneric ranges. Our findings indicate that this subspecies is strongly associated with lowland areas, with consistently high daily temperatures. We propose modifications to all range boundaries and estimate that 3% of the area of occupancy (AOO, as defined by IUCN) has already been lost due to deforestation, resulting in a current range of 224,469 km2. We also found that 54% of their AOO is currently covered by protected areas (PAs). Based on these results, we consider that this subspecies is currently properly classified as Least Concern, because it occupies an extensive range, which is relatively well covered by PAs, and is currently experiencing low rates of deforestation.
The ABC's of Alzheimer risk gene ABCA7
Authors: Duchateau Lena , Wawrzyniak Nicole , Sleegers Kristel 
Published: April 2024

AbstractAlzheimer's disease (AD) is a growing problem worldwide. Since ABCA7’s identification as a risk gene, it has been extensively researched for its role in the disease. We review its recently characterized structure and what the mechanistic insights teach us about its function. We furthermore provide an overview of identified ABCA7 mutations, their presence in different ancestries and protein domains and how they might cause AD. For ABCA7 PTC variants and a VNTR expansion, haploinsufficiency is proposed as the most likely mode‐of‐action, although splice events could further influence disease risk. Overall, the need to better understand expression of canonical ABCA7 and its isoforms in disease is indicated. Finally, ABCA7's potential functions in lipid metabolism, phagocytosis, amyloid deposition, and the interplay between these three, is described. To conclude, in this review, we provide a comprehensive overview and discussion about the current knowledge on ABCA7 in AD, and what research questions remain.Highlights
Alzheimer's risk‐increasing variants in ABCA7 can be found in up to 7% of AD patients.
We review the recently characterized protein structure of ABCA7.
We present latest insights in genetics, expression patterns, and functions of ABCA7.
Precision Engineering of the Co‐immobilization of Enzymes for Cascade Biocatalysis
Authors: Luo Zhiyuan , Qiao Li , Chen Haomin , Mao Zhili , Wu Shujiao , Ma Bianqin , Xie Tian , Wang Anming , Pei Xiaolin , Sheldon Roger A. 
Published: April 2024

AbstractThe design and orderly layered co‐immobilization of multiple enzymes on resin particles remain challenging. In this study, the SpyTag/SpyCatcher binding pair was fused to the N‐terminus of an alcohol dehydrogenase (ADH) and an aldo‐keto reductase (AKR), respectively. A non‐canonical amino acid (ncAA), p‐azido‐L‐phenylalanine (p‐AzF), as the anchor for covalent bonding enzymes, was genetically inserted into preselected sites in the AKR and ADH. Employing the two bioorthogonal counterparts of SpyTag/SpyCatcher and azide–alkyne cycloaddition for the immobilization of AKR and ADH enabled sequential dual‐enzyme coating on porous microspheres. The ordered dual‐enzyme reactor was subsequently used to synthesize (S)‐1‐(2‐chlorophenyl)ethanol asymmetrically from the corresponding prochiral ketone, enabling the in situ regeneration of NADPH. The reactor exhibited a high catalytic conversion of 74 % and good reproducibility, retaining 80 % of its initial activity after six cycles. The product had 99.9 % ee, which that was maintained in each cycle. Additionally, the double‐layer immobilization method significantly increased the enzyme loading capacity, which was approximately 1.7 times greater than that of traditional single‐layer immobilization. More importantly, it simultaneously enabled both the purification and immobilization of multiple enzymes on carriers, thus providing a convenient approach to facilitate cascade biocatalysis.