bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of serum NF-κB levels with peripheral neuropathy in type 2 diabetes mellitus patients: a pilot study
Authors: Priyadarsini Nibedita , Ramachandran Madumathy , Behera Kishore K. , Kiran Sheetal , Devi Sujata 
Published: March 2024

Abstract

Objectives
Hyperglycaemia-induced inflammation plays a vital role in the development of diabetic peripheral neuropathy (DPN). Recent evidences had reported the involvement of the transcription factor nuclear factor kappa-light-chain-enhancer of activated B cell (NF-κB) in diabetic experimental models. So, this pilot study aimed to evaluate serum NF-κB levels in DPN patients.

Methods
We recruited 50 T2DM patients, of which 25 were T2DM with neuropathy and 25 were T2DM without neuropathy. In all the participants peripheral neuropathy was diagnosed based on Total neuropathy score (TNS). Serum NF-κB levels were measured by ELISA.

Results
We observed that the serum NF-κB levels were higher in DPN patients in comparison to T2DM patients without neuropathy. On spearman correlation, a positive correlation was found between serum NF-κB levels and TNS in the DPN group (r=0.741, p<0.001). The regression model shows the TNS to be an independent determinant of serum NF-κB levels after adjustment for potential confounders like age, duration of diabetes, and HbA1C (B=81.34; p<0.001).

Conclusions
NF-κB activation plays a key role in promoting inflammation which is associated with the progression of DPN. In this respect, the study of NF-κB levels in serum may be an additional diagnostic marker for DPN.
The nongenomic neuroprotective effects of estrogen, E2-BSA, and G1 following traumatic brain injury: PI3K/Akt and histopathological study
Authors: Amirkhosravi Ladan , Khaksari Mohammad , Sanjari Mojgan , Khorasani Parisa 
Published: March 2024

Abstract

Objectives
Studies suggest that both genomic and nongenomic pathways are involved in mediating the salutary effects of steroids following traumatic brain injury (TBI). This study investigated the nongenomic effects of 17β-estradiol (E2) mediated by the PI3K/p-Akt pathway after TBI.

Methods
Ovariectomized rats were apportioned to E2, E2-BSA (E2 conjugated to bovine serum albumin), G1 [G-protein-coupled estrogen receptor agonist (GPER)] or their vehicle was injected following TBI, whereas ICI (classical estrogen receptor antagonist), G15 (GPER antagonist), ICI + G15, and their vehicles were injected before the induction of TBI and injection of drugs. Diffuse TBI was induced by the Marmarou model. Evans blue (EBC, 5 h), brain water contents (BWC), histopathological changes, and brain PI3K and p-Akt protein expressions were measured 24 h after TBI. The veterinary comma scale (VCS) was assessed before and at different times after TBI.

Results
The results showed a reduction in BWC and EBC and increased VCS in the E2, E2-BSA, and G1 groups. Also, E2, E2-BSA, and G1 reduced brain edema, inflammation, and apoptosis. The ICI and G15 inhibited the beneficial effects of E2, E2-BSA, and G1 on these parameters. All drugs, following TBI, prevented the reduction of brain PI3K/p-Akt expression. The individual or combined use of ICI and G15 eliminated the beneficial effects of E2, E2-BSA, and G1 on PI3K/p-Akt expressions.

Conclusions
These findings indicated that PI3K/p-Akt pathway plays a critical role in mediating the salutary effects of estradiol on histopathological changes and neurological outcomes following TBI, suggesting that GPER and classic ERs are involved in regulating the expression of PI3K/p-Akt.
Photo-thermo-optical modulation of Raman scattering from Mie-resonant silicon nanostructures
Authors: Vikram Mor Pal , Nishida Kentaro , Li Chien-Hsuan , Riabov Daniil , Pashina Olesiya , Tang Yu-Lung , Makarov Sergey V. , Takahara Junichi , Petrov Mihail I. , Chu Shi-Wei 
Published: March 2024

Abstract
Raman scattering is sensitive to local temperature and thus offers a convenient tool for non-contact and non-destructive optical thermometry at the nanoscale. In turn, all-dielectric nanostructures, such as silicon particles, exhibit strongly enhanced photothermal heating due to Mie resonances, which leads to the strong modulation of elastic Rayleigh scattering intensity through subsequent thermo-optical effects. However, the influence of the complex photo-thermo-optical effect on inelastic Raman scattering has yet to be explored for resonant dielectric nanostructures. In this work, we experimentally demonstrate that the strong photo-thermo-optical interaction results in the nonlinear dependence of the Raman scattering signal intensity from a crystalline silicon nanoparticle via the thermal reconfiguration of the resonant response. Our results reveal a crucial role of the Mie resonance spectral sensitivity to temperature, which modifies not only the conversion of the incident light into heat but also Raman scattering efficiency. The developed comprehensive model provides the mechanism for thermal modulation of Raman scattering, shedding light on the photon–phonon interaction physics of resonant material, which is essential for the validation of Raman nanothermometry in resonant silicon structures under a strong laser field.
Conscious walk assessment for the joint evaluation of the soundscape, air quality, biodiversity, and comfort in Barcelona
Authors: Alsina-Pagès Rosa Ma , Parés Ma Eulàlia , Vidaña-Vila Ester , Freixes Marc , Garcia Danielly , Arnela Marc , Martínez-Suquía Carmen , Serra Oriol , Ferrandiz-Rovira Mariona 
Published: March 2024

Abstract
High environmental noise as well as poor biodiversity and air pollution pose significant challenges for the European population, particularly those residing in urban areas, impacting clearly on citizens’ health. The Conscious Walk initiative stands for an innovative hybrid approach to analyse citizens’ perception of their environment. Being a citizen science participative project, Conscious Walks involves both citizens and scientists collecting high-quality acoustic, chemical, biodiversity, and comfort data while walking in pre-analysed urban environments. The main objective of this proposal is to obtain comprehensive data encompassing both subjective and objective aspects related to soundscape, air quality, biodiversity, and urban comfort. All these elements are closely tied to the overall acoustic environmental quality of the places under study. The effectiveness of this methodology has been tested in various locations in Catalonia, including Sabadell and Barcelona. This contribution focuses on the evaluation of the soundscape in the urban centre of Barcelona, with a comprehensive analysis that integrates data collected by both citizens and scientists during Conscious Walks, air quality metrics, biodiversity, and human comfort information.
Elucidating the role of ZRF1 in monocyte-to-macrophage differentiation, cell proliferation and cell cycle in THP-1 cells
Authors: Kaymak Ozdemir Aysegul , Basci Mahinur 
Published: March 2024

Abstract

Objectives
ZRF1 (Zuotin-related factor 1) is a versatile protein engaged in protein folding, gene regulation, cellular differentiation, DNA damage response, and immune system and cancer development regulation. This study investigates the role of ZRF1 in monocyte-to-macrophage transformation, and its effects on cell proliferation and the cell cycle.

Methods
We generated ZRF1-depleted THP-1 cells and induced macrophage differentiation using phorbol 12-myristate 13-acetate (PMA). Differentiation was assessed via microscopy and flow cytometry, while cell proliferation was quantified with the [3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium, inner salt] (MTS) assay, and the cell cycle was analyzed through flow cytometry using propidium iodide staining.

Results
ZRF1-depleted THP-1 cells exhibited notable morphological changes. Flow cytometry post-PMA treatment indicated these cells were smaller and less granular than controls. Proliferation rates of ZRF1-depleted monocytes and macrophages were significantly higher than controls, particularly over longer durations. Cell cycle analysis showed ZRF1 depletion notably affected the G0-G1 phase, highlighting its significant role in macrophage differentiation.

Conclusions
The findings provide important insights into ZRF1’s role in monocyte-to-macrophage differentiation and its impact on cell proliferation and the cell cycle. This research not only supports existing knowledge about ZRF1 but also enhances our understanding of its multifaceted roles in cellular processes.
Experimental Study on the Damage of Bridge Concrete in a Fire Environment Based on the Impact Echo Method
Authors: Shen Yan Peng 
Published: March 2024

Abstract
To accurately assess the damage degree of bridge structures in a fire environment, fire damage test studies were conducted on the C30 and C50 concrete specimens at different temperatures (room temperature, 100°C∼700°C) based on the impact echo method. In addition, the variation rules of mass, impact echo signal, dynamic modulus of elasticity Ed, and static and dynamic modulus of elasticity ratios (Ec/Ed) with overfire temperature were obtained. The results show the following: (1) at ablation temperature ≤ 300°C, the main frequency of the impact echo signal is single, the peak value is obvious, the signal attenuation is fast, and the change is uniform; at ablation temperature &gt; 300°C, the main frequency is frequent, there is more than one peak, and the vibration duration of the phenomenon is longer. (2) After fire damage, the specimen’s dynamic modulus of elasticity Ed is in a cubic relationship with the overfire temperature. (3) In engineering practice, the static and dynamic modulus of elasticity (Ec/Ed) ratio is classically based on Lydon and Balendran’s formula, which is usually used for derivation at room temperature. This article found that the formula can be extended to the rough estimation at lower temperatures (≤200°C), and the model proposed in this article can be used for the derivation of the static modulus of elasticity Ec and the dynamic modulus of elasticity Ed at high temperatures. In summary, the impact echo method can be used to quantitatively assess the damage state of bridges after fire. After the signal time-frequency domain conversion, a qualitative assessment of the degree of concrete damage can be made. Furthermore, a quantitative assessment of bridge concrete after fire damage can be made using the model proposed in this article.
Estimation of thermodynamics properties as a measure of the extent of interference in a conducting polymer based electrochemical aqueous ion sensor
Authors: Dutta Kusumita , Panda Siddhartha 
Published: March 2024

Background: Interference of other ions towards the target analyte in an electrochemical sensor is typically estimated utilizing the peak reduction (PR) technique and the selectivity coefficient technique, both of which have limitations. In our earlier works, a scale of interference was developed using the barrier width (BW) technique based on Simmon’s model utilizing a conducting polymer-based sensor for the detection of Cd2+ by square wave voltammetry (SWV). Also, a new scale of interference was generated with higher resolution by incorporating the BW technique along with adsorption isotherms and the PR technique.
Methods: The present work takes the investigation further at the electrode-electrolyte interface to explain the interference effect using thermodynamic parameters such as the partition coefficient, enthalpy and reorganization energy. The length of the reaction site for Cd2+ can also measure interference effect. In this work, SWV for Cd2+ detection in presence of interfering species at different temperatures were conducted, -ΔGad values were extracted and all the thermodynamic parameters were evaluated. The novelty of this work lies in incorporation of these thermodynamic parameters along with BW values (d) to explain the interference phenomena.
Results: The variation of the thermodynamic properties for Cd2+ in presence of interfering species were examined. Correlation coefficients were developed from the thermodynamic parameters and the d values to explain the extent of interference.
Conclusions: This study can provide information on the thermodynamic properties which can be predicted from BW technique. The correlation coefficients would help obtain an estimate of the interference with the need of lesser number of experiments.
Determinants of breast cancer prevention in a group of women with cancer suspicion
Authors: Kwilosz Edyta , Grzesik-Gąsior Joanna , Dobrowolska Patrycja 
Published: March 2024

WstępW związku ze stałym wzrostem zachorowalności na raka sutka na świecie coraz ważniejsze staje się monitorowanie działań profilaktycznych oraz zwiększanie prozdrowotnej świadomości społeczeństw w zakresie nowotworów piersi, szczególnie w grupie osób, u których prawdopodobieństwo wystąpienia problemu onkologicznego jest duże. Celem badania była analiza wybranych czynników determinujących podejmowanie przez kobiety działań w zakresie profilaktyki raka piersi.Materiał i metodyBadanie prowadzono metodą sondażu diagnostycznego wśród 121 kobiet, pacjentek poradni onkologicznej Podkarpackiego Ośrodka Onkologicznego w Brzozowie. Ocenie poddano wiedzę kobiet, wskaźniki socjodemograficzne oraz dodatni wywiad rodzinny w kierunku raka piersi. Narzędzie stanowił autorski kwestionariusz ankiety. Do weryfikacji hipotez wykorzystano test chi-kwadrat (χ<sup>2</sup>). Przyjęto poziom istotności p < 0,05.WynikiNajczęstszym źródłem wiedzy na temat profilaktyki raka piersi był Internet (52,89%), a głównym powodem rezygnacji z badań profilaktycznych brak świadomości o zagrożeniu, jakie niesie ze sobą choroba (38,84%). U ponad 30% badanych stwierdzono niski poziom wiedzy, który był zróżnicowany statystycznie w zależności od wykształcenia (p < 0,001) oraz wieku badanych (p = 0,01). Kobiety młodsze oraz lepiej wykształcone wykazywały wyższy poziom wiedzy, który był związany z regularnością podejmowanych działań profilaktycznych (p = 0,048) oraz wykonywaniem samobadania piersi (p < 0,001). Wystąpienie raka piersi w rodzinie miało wpływ na regularność samobadania oraz wykonywanie badań diagnostycznych w kierunku raka piersi (p < 0,001).WnioskiPoziom wiedzy na temat profilaktyki raka piersi w badanej grupie nie był w pełni zadowalający i wymaga uzupełnienia. Wskazanie przez kobiety Internetu jako głównego źródła wiedzy wskazuje na konieczność zwiększenia udziału specjalistów medycznych w edukacji onkologicznej. Najważniejszymi predyktorami regularnie podejmowanych działań profilaktycznych są młody wiek, wyższy poziom wiedzy, wyższe wykształcenie oraz dodatni wywiad rodzinny (nowotwór piersi).
Analisis PERPRES Nomor 55 Tahun 2019 Terkait Program Kendaraan Listrik Dalam Rangka Mewujudkan Transportasi Ramah Lingkungan
Authors: Subiantoro Hernowo , Maharani Andina Elok Puri 
Published: March 2024

ABSTRACT
The emergence of environmental issues and the fossil-based energy crisis has encouraged the development of environmentally friendly transportation. The purpose of the research is to analyze whether Presidential Regulation Number 55 of 2019 has been able to realize the acceleration of environmentally friendly transportation and the ideal policy related to the electric vehicle acceleration program. The type of research used is normative juridical with a statutory, and conceptual approach. The results showed that Presidential Regulation Number 55 of 2019 as the main legal instrument for the acceleration of the electric vehicle program is in fact not fully able to realize the acceleration of environmentally friendly transportation with indicators including the ambiguity of legal certainty because there is an antithesis between the reality that occurs and the desired expectations, a deeper study is needed regarding the most effective form of regulation in responsive positive law, and there is a gap for environmental damage (Jevons Paradox) as a result of the industrialization of electric vehicles. The ideal policy of environmentally friendly transportation is at least able to consistently realize good governance, create legal certainty, and authority based on laws and regulations.

Keywords: Affordable & Clean Energy, Electric Vehicles, Green Transportation.

ABSTRAK
Munculnya issu lingkungan dan krisis energi berbasis fosil telah mendorong berkembangnya transportasi ramah lingkungan. Tujuan penelitian untuk menganalisa keefektifan Perpres RI Nomor 55 Tahun 2019 untuk mewujudkan akselerasi transportasi yang ramah lingkungan dan bagaimana kebijakan ideal terkait program percepatan kendaraan Listrik. Jenis penelitian yang digunakan adalah yuridis normatif dengan pendekatan perundang-undangan, dan konseptual. Hasil penelitian menunjukkan bahwa Perpres Nomor 55 Tahun 2019 sebagai instrumen hukum utama percepatan program kendaraan listrik ini faktanya belum sepenuhnya mampu mewujudkan akselerasi transportasi ramah lingkungan dengan indikator antara lain ambiguitas kepastian hukum karena terjadi antitesis antara kenyataan yang terjadi dengan harapan yang diinginkan, diperlukan telaah lebih mendalam mengenai bentuk aturan paling efektif dalam hukum positif yang responsif, dan terdapat celah bagi terjadinya kerusakan lingkungan (Jevons Paradox) sebagai dampak industrialisasi kendaraan listrik. Kebijakan ideal transportasi ramah lingkungan setidaknya mampu secara konsisten mewujudkan tata kelola pemerintahan yang baik (good governance), terciptanya kepastian hukum, dan kewenangan yang berdasarkan peraturan perundang-undangan.

Kata Kunci: Energi bersih & terbarukan, Kendaraan Listrik, Transportasi Ramah Lingkungan.
Kedudukan Barang Bukti Yang Diperoleh Secara Melawan Hukum Dalam Putusan Mahkamah Agung Nomor 1614 K/ Pid.Sus /2012
Authors: A. Zainur Rasyidi Ramadhani  
Published: March 2024

Abstract
National Police of the Republic of Indonesia is a institution that has functions to provide protection to the society. For the implementation of enforcement law, investigator conducts inquiry and investigation as the first step of the whole law enforcement process. Unfortunately, police officers often obtain unlawful evidence during the investigation process in order to frame a suspect. Admissibility of Evidence is invalid. This situation make no chance for the framed suspect to fight for the rights. Indonesian criminal procedure law establishes “pretrial”court process which facilitate the supervision of the investigation process. Through the Decision of the Constitutional Court Number 21/PUU- XII/2014, there is an additional object to the pretrial process, that is the determination of the suspect. Through this decision, the party who is harmed by the police’s unlawful action will be able to conduct a pretrial legal effort in order to protect their rights on a fair investigation.
Keywords: Admissibility of Evidence, Unlawful, Legal Efforts, Pretrial.

Abstrak
Kepolisian Negara Republik Indonesia adalah salah satu lembaga penegak hukum yang berfungsi melakukan tindakan pencegahan terhadap terjadinya kejahatan dan memberikan perlindungan terhadap seluruh masyarakat. Demi terlaksananya hukum pidana dan hukum acara pidana, tindakan penyelidikan dan penyidikan yang dilakukan oleh kepolisian adalah sebagai langkah awal dalam proses penegakan hukum. Perolehan barang bukti secara melawan hukum seringkali dilakukan oleh polisi dalam penyidikan untuk mendapatkan tersangka. Kedudukan barang bukti tersebut patut untuk dipertanyakan. Keadaan kekurangan instrumen hukum membuat pelaku tersebut tidak terjamah dan tidak ada kesempatan bagi tersangka untuk memperjuangkan haknya. Hukum acara pidana Indonesia membentuk pranata praperadilan yang fungsinya sebagai wadah untuk melakukan pengawasan terhadap proses penyidikan. Melalui putusan Mahkamah Konstitusi Nomor 21/PUU– XII/2014, terdapat penambahan pada objek praperadilan yaitu penetapan tersangka. Melalui putusan ini, pihak yang merasa dirugikan terhadap perilaku polisi tersebut dapat melakukan upaya hukum praperadilan sehingga hak asasi manusia tersangka dapat terpenuhi.
Kata Kunci: Kedudukan Barang Bukti, Melawan Hukum, Upaya Hukum, Praperadilan.
Keberatan Pihak Ketiga Yang Beritikad Baik Terhadap Perampasan Aset Dalam Tindak Pidana Korupsi
Authors: Evander  
Published: March 2024

Abstract
Evidence is an item of crime and one of the important pieces of evidence in uncovering a crime. Evidence is not always owned by the Defendant but is under the control of a third party with good intentions. This action violated the provisions of Article 28H paragraph (4) of the 1945 Constitution where third party property rights were taken by force. To respond to these problems, Article 19 paragraph (2) of the PTPK Law has protected third parties who have good intentions through “Keberatan” but there are limitations in submitting them so that they violate article 573 BW. The breach was resolved with the advent of PERMA 2/2022. PERMA 2/2022 stipulates that “Keberatan” can be filed based on a first level decision, appeal or cassation. The addition of norms in PERMA 2/2022 raises a problem where Article 19 paragraph (2) of the PTPK Law and PERMA 2/2022 are not aligned and there are legal issues, namely whether there is a conflict of norms.
Keywords: evidence, “PERMA 2/2022”, Article 19 paragraph (2) of the “PTPK” Law, “Keberatan”, third party with good intentions.

Abstrak
Barang bukti merupakan barang kejahatan dan salah satu alat bukti penting dalam mengungkap kejahatan. Barang bukti tidak selalu dimiliki oleh Terdakwa tetapi berada dibawah kekuasaan pihak ketiga yang beritikad baik. Tindakan tersebut melanggar ketentuan Pasal 28H ayat (4) UUD 1945 dimana hak milik pihak ketiga diambil secara paksa. Untuk menanggapi permasalahan tersebut, Pasal 19 ayat (2) UU PTPK telah melindungi pihak ketiga yang beritikad baik lewat upaya Keberatan tetapi terdapat batasan dalam mengajukannya sehingga melanggar pasal 573 BW. Pelanggaran tersebut diselesaikan dengan munculnya PERMA 2/2022. PERMA 2/2022 mengatur bahwa Keberatan dapat diajukan berdasarkan putusan tingkat pertama, banding atau kasasi. Penambahan norma dalam PERMA 2/2022 tersebut menimbulkan permasalahan dimana pasal 19 ayat (2) UU PTPK dengan PERMA 2/2022 tidak selaras dan terdapat isu hukum, yakni apakah terjadi konflik norma.
Kata Kunci: barang bukti, PERMA 2/2022, pasal 19 ayat (2) UU PTPK, Keberatan, pihak ketiga yang beritikad baik