bluuebunny/crossref_metadata_2025_split huggingface dataset:
Expression Profile–Defined Classification of Lung Adenocarcinoma Shows Close Relationship With Underlying Major Genetic Changes and Clinicopathologic Behaviors
Authors: Takeuchi Toshiyuki , Tomida Shuta , Yatabe Yasushi , Kosaka Takayuki , Osada Hirotaka , Yanagisawa Kiyoshi , Mitsudomi Tetsuya , Takahashi Takashi 
Published: March 2006

Purpose This study was conducted to gain insight into the relationship between expression profiles and underlying genetic changes, which are known to be important for the pathogenesis of lung cancers. Methods Expression profiles of 18,175 unique genes and three major targets for genetic changes, p53, epidermal growth factor receptor (EGFR), and K-ras, were investigated in 149 patients with non–small-cell lung cancer, including 90 patients with adenocarcinoma to determine their relationships with various clinicopathologic features and Gene Ontology (GO) terms. Results This study successfully established a basis for expression profile-defined classification, which can classify adenocarcinomas into two major types, terminal respiratory unit (TRU) type and non–TRU type. Our GO term–based identifier of particular biologic processes, molecular functions, and cellular compartments clearly showed characteristic retention of normal peripheral lung features in TRU type, in sharp contrast to the significant association of non–TRU type with cell cycling and proliferation-related features. While significantly higher frequency of EGFR mutation was observed in TRU type, we found that the presence of EGFR mutations was a significant predictor of shorter postoperative survival for TRU type, independent of disease stage. We were also able to identify a set of genes in vivo with significant upregulation in the presence of EGFR mutations. Conclusion This study has shed light on heterogeneity in lung cancers, especially in adenocarcinomas, by establishing a molecularly, genetically, and clinically relevant, expression profile-defined classification. Future studies using independent patient cohorts are warranted to confirm the prognostic significance of EGFR mutations in TRU-type adenocarcinoma.
Clinicopathologic Significance of Defective DNA Mismatch Repair in Endometrial Carcinoma
Authors: Black Destin , Soslow Robert A. , Levine Douglas A. , Tornos Carmen , Chen Shirley C. , Hummer Amanda J. , Bogomolniy Faina , Olvera Narciso , Barakat Richard R. , Boyd Jeff 
Published: March 2006

Purpose Defective DNA mismatch repair is commonly present in sporadic manifestations of gastrointestinal, endometrial, and other cancers. The pathognomonic molecular manifestation of this repair defect is microsatellite instability (MSI). Here, we test the hypothesis that MSI predicts the clinicopathologic features of endometrial carcinoma. Patients and Methods A retrospective cohort of 473 patients treated for endometrial carcinoma at this institution was identified. All cases were reviewed by a gynecologic pathologist, and clinical information was abstracted from medical records. Using consensus criteria, DNA samples from nontumor and tumor tissue pairs were genotyped for MSI. Associations between MSI status and pathologic and clinical variables were assessed. Results Ninety-three (20%) of 473 tumors were MSI+. In the MSI+ tumor group compared with the MSI− tumor group, the proportion of advanced compared with early-stage tumors was higher (92% v 81%; P = .01), as was the proportion of tumors of endometrioid compared with nonendometrioid histologic subtype (94% v 23%; P = .001), and the proportion of tumors with myometrial invasion compared with those with none (92% v 78%; P = .01). By multivariate analyses, disease-free survival (hazard ratio, 0.3; 95% CI, 0.2 to 0.7) and disease-specific survival (hazard ratio, 0.3; 95% CI, 0.1 to 0.8) were significantly improved in patients with MSI+ tumors. Conclusion In endometrial carcinoma, the presence of MSI was independently associated with a more favorable clinical outcome.
Association of the PDCD5 Locus With Lung Cancer Risk and Prognosis in Smokers
Authors: Spinola Monica , Meyer Peter , Kammerer Stefan , Falvella F. Stefania , Boettger Melanie B. , Hoyal Carolyn R. , Pignatiello Carmen , Fischer Reiner , Roth Richard B. , Pastorino Ugo , Haeussinger Karl , Nelson Matthew R. , Dierkesmann Rainer , Dragani Tommaso A. , Braun Andreas 
Published: March 2006

Purpose Whole-genome scan association analysis was carried out to identify genetic variants predictive of lung cancer risk in smokers and to confirm the identified variants in an independent sample. Patients and Methods A case-control study was performed using two pools consisting of DNA from 322 German smoking lung cancer patients and 273 healthy smoking controls, respectively. A replication study was carried out using 254 Italian lung adenocarcinoma (ADCA) patients and 235 healthy controls. Results Patients with genotypes GG or CG for the rs1862214 single nucleotide polymorphism, 5′ upstream of the programmed cell death 5 (PDCD5) gene, compared with those with the common genotype CC showed an increased risk of lung cancer (odds ratio, 1.6; 95% CI, 1.2 to 2.1) and a higher incidence of poor clinical stage disease (hazard ratio [HR], 1.9; 95% CI, 1.1 to 3.4; P = .023), nodal involvement (HR, 1.9; 95% CI, 1.1 to 3.6; P = .033), and short-term survivorship (HR, 1.8; 95% CI, 1.2 to 2.6, P = .003). PDCD5 mRNA expression levels were approximately 2.4-fold lower in lung ADCA as compared to normal lung tissue. Human NCI-H520 cancer cells transfected with PDCD5 cDNA showed decreased colony-forming ability. Conclusion These results suggest that the rs1862214 polymorphism in PDCD5 is predictive for lung cancer risk and prognosis, and that PDCD5 may represent a novel tumor suppressor gene influencing lung cancer.
Formal Total Synthesis of (−)-Dendrobine Using Zirconium Promoted Cyclization. Determination of the Absolute Configuration of the Intermediary Tricyclic Ketone
Authors: Mori Miwako , Saitoh Fumihiko , Uesaka Noriaki , Shibasaki Masakatsu 
Published: March 2006

Abstract
The optical purity of (−)-dendrobine synthesized using zirconium promoted cyclization was improved and the absolute configuration of the intermediary tricyclic ketone was determined using the improved Mosher’s method developed by Kusumi.
Electron Donor-Acceptor Complexes of the Fullerenes C60 and C70 with Amines
Authors: Seshadri Ram , D’Souza Francis , Krishnan Varadachari , Rao CNR 
Published: March 2006

Abstract
Based on electronic absorption spectroscopy, C60 is found to form complexes with aromatic amines with an enthalpy of association in the range 9–16 kJ mol−1. Interaction of C70 with the amines is negligible. Cyclic voltammetric measurements confirm these observations.
Complex Formation between Poly(methyl vinyl ether) and γ-Cyclodextrin
Authors: Harada Akira , Li Jun , Kamachi Mikiharu 
Published: March 2006

Abstract
γ-Cyclodextrin forms an inclusion complex with poly(methyl vinyl ether) in a definite stoichiometry in high yield, although α-cyclodextrin and β-cyclodextrin did not form complexes with poly(methyl vinyl ether). The inclusion complex is a thermally stable crystalline compound.
Synthesis and X-Ray Structure of 4′-Thiothymidine
Authors: Uenishi Jun’ichi , Takahashi Keiji , Motoyama Mitsuhiro , Akashi Haruo 
Published: March 2006

Abstract
4′-Thiothymidine was synthesized by SnCl4 mediated coupling of 5-O-acetyl-3-O-tert-butyldimethylsilyl-2-deoxy-4-thio-d-erythro-pentofuranoside with 2,4-bis(trimethylsilyl)thymine and the structure was determined by X-ray analysis.
Electrocatalytic Oxidative Coupling of Methylquinolines on TEMPO-modified Graphite Felt Electrodes
Authors: Kashiwagi Yoshitomo , Ono Hiroaki , Osa Tetsuo 
Published: March 2006

Abstract
2- and 4-Methylquinolines were oxidized to 2,2′-dimethyl-4,4′-biquinolyl and 4,4′-dimethyl-2,2′-biquinolyl, respectively, both in ca. 94% isolated yield and ca. 90% current efficiency on a graphite felt electrode coated with a thin poly(acrylic acid) layer containing 4-amino-2,2,6,6-tetramethylpiperidinyl-1-oxyl (4-amino-TEMPO). The reaction proceeds via electrocatalytic oxidation of the modified-TEMPO species. The electrode was not inactivated during electrolysis and could be used repeatedly.
Preparation of Monodisperse Poly(N-vinylformamide) Particles by Dispersion Polymerization in Methanol Solvent
Authors: Uyama Hiroshi , Kato Hisataka , Kobayashi Shiro 
Published: March 2006

Abstract
Dispersion polymerization of N-vinylformamide (NVF) was performed in methanol using a hydrophilic polymer or a poly(2-methyl-2-oxazoline) macromonomer as a stabilizer. The polymerization of NVF using poly(2-ethyl-2-oxazoline) as stabilizer gave relatively monodisperse polymer particles in the size of micron range. In using the macromonomer, monodisperse PNVF particles in the sub-micron range were obtained.
Hypervalent Bond Formation and Interaction between Heavier Group 16 Elements in the Dihalides and Oxide of 5H,7H-Dibenzo[b,g][1,5]-ditellurocin and -telluraselenocin
Authors: Fujihara Hisashi , Uehara Toshinori , Erata Tomoki , Furukawa Naomichi 
Published: March 2006

Abstract
The reaction of 5H,7H-dibenzo[b,g][1,5]ditellurocin with I2 resulted in the formation of the diiodo-ditellurane as a new class of bis-hypervalent chalcogenide. Treatment of the dibromo-derivative of 5H,7H-dibenzo[b,g][1,5]telluraselenocin with aqueous NaOH solution afforded exclusively the telluroxide which showed the strong transannular hypervalent interaction between the tellurinyl group and the selenyl group as evidenced by 77Se and 125Te NMR spectroscopy.
Structure of 1,2-Dilithio[tetrakis(trimethylsilyl)]ethane in Solution. Observation of Lithium–Bridged Structures and Unexpected Anionic Rearrangement
Authors: Sekiguchi Akira , Ichinohe Masaaki , Nakanishi Tetsuo , Sakurai Hideki 
Published: March 2006

Abstract
6Li and 13C NMR spectra of 1,2-dilithio[tetrakis(trimethylsilyl)]ethane revealed a doubly bridged π-structure in aromatic solvents similar to that observed in the crystals. However, the dianion in THF, which was found to exist as a solvent–separated ion pair of Li+(THF)4 and a species bridged by one Li atom, was reactive to undergo anionic rearrangement.
Synthesis of a Novel π-Conjugated Organometallic Polymer, Poly(4,4′-biphenylene 2,5-cobaltacylopenta-2,4-dienylene), by Metallacycling Polymerization (MCP)
Authors: Ohkubo Akira , Aramaki Kunitsugu , Nishihara Hiroshi 
Published: March 2006

Abstract
A new π-conjugated organometallic polymer of which framework is in part composed of cobaltacyclopentadienes has been synthesized by a metallacycle formation reaction of CpCo(PPh3)2 with 4,4′-diethynylbiphenyl. The polymer, poly(4,4′-biphenylene 2,5-cobaltacyclopenta-2,4-dienylene) has a strong absorption band around 500 run, and is oxidized at +0.306 V vs. Ag/Ag+ in dichloromethane and reduced at −1.8 V in acetonitrile.
Synthesis and Molecular Structure of trans-PdCl2{o-Ph2PC6H4CH2O-(CH2)3-2-C5H4N}. The First Transition Metal Complex Containing trans Coordinating Bidentate Pyridyl-phosphine Ligand
Authors: Yabuta Masami , Nakamura Shingo , Yamagata Tsuneaki , Tani Kazuhide 
Published: March 2006

Abstract
As the first example of a crystallographically confirmed transition metal complex with a bidentate hybrid ligand spanning trans positions, the square-planar palladium(II) complex containing the trans chelating pyridyl-phosphine bidentate hybrid ligand, bound through a pyridine and a phosphine, trans-PdCl2{o-Ph2PC6H4CH2O(CH2)3-2-C5H4N}, is prepared and the crystal structure was determined.
Asymmetric Aerobic Epoxidation of Unfunctionalized Olefins Catalyzed by Optically Active α-Alkoxycarbonyl-β-ketoiminato Manganese(III) Complexes
Authors: Mukaiyama Teruaki , Yamada Tohru , Nagata Takushi , Imagawa Kiyomi 
Published: March 2006

Abstract
Optically active N,N′-ethylenebis(α-alkoxycarbonyl-β-ketoimine) was found to be a new class of effective ligand of manganese(III) complex catalyst for the asymmetric aerobic epoxidation of simple olefins, such as 1,2-dihydronaphthalene derivatives, to afford the corresponding optically active epoxides with good to high enantioselectivities.
A Novel Antileukemic Tropoloisoquinoline Alkaloid, Pareirubrine, from Cissampelos pareira
Authors: Morita Hiroshi , Matsumoto Kouji , Takeya Koichi , Itokawa Hideji , Iitaka Yoichi 
Published: March 2006

Abstract
Pareirubrine, a novel tropoloisoquinoline alkaloid with antileukemic activity was isolated from Cissampelos pareira and the structure was determined on the basis of its spectroscopic data and X-ray diffraction analysis.
Complexation of Cycloinulonexaose with Some Metal Ions
Authors: Yoshie Naoko , Hamada Hiroaki , Takada Shigehiro , Inoue Yoshio 
Published: March 2006

Abstract
Cycloinulohexaose(CF6), which is a cyclohexaose composed of six(2→1) linked β-d-fructofuranosyl units, has a 18-crown-6 skeleton in its center. Selective complexation of CF6 with some metal ions have been observed in D2O by NMR spectroscopy. The variation of 1H NMR chemical shifts indicates that the ether oxygen atoms or CF6 should act as electron donors, which interact electrostatically with the metal ions.
The Surface Modification of Graphite Particles by Direct Fluorination
Authors: Chong Yong-bo , Watanabe Nobuatsu , Idogawa Hiroyuki , Wakata Atsushi 
Published: March 2006

Abstract
The dispersion stability of graphite particles in water was largely increased by a surface modification of direct fluorination. The fluorinated graphite particles in water did not flocculate and kept stable suspension for long time, and it was found that the surface of fluorinated graphite particles became more hydrophilic and was highly polarized in water.
Lanthanoid(III) Alkoxides as Novel Catalysts for a Rapid Transhydrocyanation from Acetone Cyanohydrin to Aldehydes and Ketones
Authors: Ohno Hiroshi , Mori Atsunori , Inoue Shohei 
Published: March 2006

Abstract
A rapid transhydrocyanation from acetone cyanohydrin to several aldehydes and ketones is promoted by a catalytic amount of lanthanoid(III) alkoxide to provide the corresponding cyanohydrins.
Photocatalytic Micropatterning of Titanium Oxide Surface with Platinum
Authors: Sugimura Hiroyuki , Uchida Tatsuya , Kitamura Noboru , Masuhara Hiroshi 
Published: March 2006

Abstract
Platinum (Pt) micropatterns were fabricated photocatalytically on titanium oxide (TiO2) surface by projecting a reduced light image of a photomask. Negative and positive Pt patterns on TiO2 with the spatial resolution better than 10 μm were obtained by photoreduction of PtCl42− to Pt in aqueous K2PtCl4 solution and photoetching of the deposited Pt in aqueous HCl solution, respectively.
Preparation and Properties of New π-Conjugated Poly(benzimidazole-4,7-diyl) and Poly(2,1,3-benzothiadiazole-4,7-diyl)
Authors: Kanbara Takaki , Yamamoto Takakazu 
Published: March 2006

Abstract
Dehalogenation polycondensation of 4,7-dibromobenzimidazole and 4,7-dibromo-2,1,3-benzothiadiazole with a zero-valent nickel complex afford poly(benzimidazole-4,7-diyl) and poly(2,1,3-benzothiadiazole-4,7-diyl), respectively. These polymers give rise to electrochemically active doping-undoping cycles in both reduction and oxidation regions, and are converted into electrically conducting materials on both n- and p-type chemical doping.
Preparation of Samarium(II) Triflate and It Mediated Grignard-type Reaction. In Situ Formation and Reaction of New Organosamarium Reagents
Authors: Fukuzawa Shin-ichi , Tsuchimoto Teruhisa , Kanai Takeshi 
Published: March 2006

Abstract
Samarium(II) triflate was readily prepared by the reaction of samarium(III) triflate with sec-butyllithium at room temperature in THF. Its reducing ability was examined by pinacol coupling of carbonyl compounds. Sm(OTf)2 mediated Grignard-type reaction in THF-HMPA effectively; alkylation and allylation of ketones or aldehydes by simple alkyl, allyl, and benzyl halides proceeded via organosamarium intermediates.
Orientation Dependence of Transition Matrix Elements for Energy Transfer Reaction CF3H + Ar(3P) → CF3* + Ar + H
Authors: Takahashi Hideaki , Ohoyama Hiroshi , Kasai Toshio , Kuwata Keiji , Nakano Masayoshi , Yamaguchi Kizashi 
Published: March 2006

Abstract
Transition matrix elements for the energy transfer were explicitly evaluated by ab initio SCF calculations in the CF3H + Ar(3P) → CF3* + Ar + H reaction. The matrix elements were obtained as functions of mutual orientation and distance between the reactants. The results show that the collision along the symmetry axis of the CF3H is preferable to produce the excited CF3H in the B or C state. On the other hand, the E state was found to be preferably generated by the side-on attack of Ar(3P). The present results agree well with the ones given by the electron density analysis, suggesting that the electron exchange process is dominant for showing the steric anisotropy in the title reaction.
A Novel Approach for Synthesis of Carbyne by Electroreductive Polymerization of Diiodoacetylene Catalyzed by Ni Complex
Authors: Kijima Masashi , Sakai Yuji , Shirakawa Hideki 
Published: March 2006

Abstract
Diiodoacetylene was electropolymerized with Pt cathode at −2.0 V (vs. SCE) in the presence of Ni complex in dimethylformamide (DMF) under anaerobic conditions, giving an insoluble black powder which had a strong infrared absorption at 2050 cm−1 and a broad Raman peak around 2150 cm−1 due to conjugated polyyne structure. A compressed pellet of the as-prepared sample had an electrical conductivity of 3 × 10−5 S cm−1.
Photodecomposition Mechanism of o-Diazonaphthoquinones Studied by Laser Flash Photolysis with Infrared Detection
Authors: Oishi Shigero , Watanabe Yuriko , Kuriyama Yasunao 
Published: March 2006

Abstract
Laser flash photolysis of an o-diazonaphthoquinone traced by monitoring infrared in parallel with ultraviolet revealed the dynamic behavior of ketene intermediate, which appeared immediately after the laser pulse and changed swiftly to next intermediate. The fact that the conversion of ketene did not correspond to the formation of ketene hydrate suggested the existence of another intermediate between ketene and ketene hydrate.
Coexistence of Two Cholesteric Phases in Poly(γ-benzyl L-glutamate) Liquid Crystals
Authors: Mori Norio , Itou Satoshi 
Published: March 2006

Abstract
Coexistence of two cholesteric phases has been observed in poly(γ-benzyl L-glutamate)-1,2-dichloroethane solutions. The two cholesteric phases are distinguished from the length of the pitch under an optical polarizing microscope. Temperature dependence of the pitch differs significantly from each other.
Synthesis of Cationic Imine- and Amine-Coordinated Hydridoruthenium Complexes Relevant to Reductive Amination
Authors: Rappert Thomas , Yamamoto Akio 
Published: March 2006

Abstract
The dihydridoruthenium complex cis-RuH2(PMe3)4 reacts with NH4PF6 in acetone to produce cis-[RuH(NH3)(PMe3)4]PF6, cis-[RuH(NH=CMe2)(PMe3)4]PF6 and cis-[RuH(NH2CHMe2)(PMe3)4]PF6. The isopropylamine ligand originates from reductive animation of the solvent. A possible reaction pathway is discussed.
Potassium Exchanged Layered Zirconium Phosphate as Base Catalyst in the Synthesis of 2-Nitroalkanols
Authors: Costantino U , Curini M , Marmottini F , Rosati O , Pisani E 
Published: March 2006

Abstract
The synthesis of 2-nitroalkanols from nitroalkanes and aldehydes occurs efficiently, in mild conditions without solvent, when mediated by layered Zr(KOPO3)2. The reaction has been tested in the preparation of ten different nitroalkanols and the data obtained seem to indicate that not only the surface but also the interlayer ≡P–O−K+ groups are involved in the catalytic process.
Alkali Metal Reduction of Oligo-6-(2-thienyl)pentafulvenes. Synthesis of Oligothienylenemethines Attached with Cyclopentadienide Groups
Authors: Kurata Hiroyuki , Kawase Takeshi , Oda Masaji 
Published: March 2006

Abstract
Oligo-6-(2-thienyl)pentafulvenes smoothly undergo alkali metal reduction to form novel, stable oligothienylenemethines attached with cyclopentadienide groups as confirmed by UV-Vis and NMR spectra.
Structural Regularity-Waveguide Property Relationships of Langmuir-Blodgett Films
Authors: Kuri Taishi , Honda Namiko , Oishi Yushi , Kajiyama Tisato 
Published: March 2006

Abstract
Relationship between structure regularity and the propagation loss of Langmuir-Blodgett(LB) film waveguides was investigated. The LB film with a homogeneous surface morphology could be constructed from the mechanically stable monolayer prepared by the multi-step creep method. The propagation loss of the LB film waveguide was decreased by the surface flatness of the LB film.
Nuchal translucency thickness measurements for fetal aneuploidy screening: Log NT-MoM or Delta-NT, performer-specific medians and ultrasound training
Authors: Gyselaers Wilfried J A , Vereecken Annie J , Van Herck Erik J H , Straetmans Dany P L , Ombelet Willem U A M , Nijhuis Jan G 
Published: March 2006

Objectives: To evaluate in fetal aneuploidy screening the desirability of using Fetal Medicine Foundation (FMF) normal medians of nuchal translucency thickness (NT) measurements or performer-specific medians, and whether the NT measurements should be expressed as Delta-NT or Log NT-MoM values. Settings: First trimester-combined screening programme in a low risk population in Flanders, Belgium (Algemeen Medisch Laboratorium, Antwerp). Methods: Pregnancies unaffected by trisomy 21 (T21) were screened by FMF-trained or other ultrasonographers. Performer-specific NT medians were established for FMF-trained and other ultrasonographers. NCSS Statistical Software was used to establish probability plots for Log NT-MoM and Delta-NT values, relative to performer-specific references or to the FMF-reference. Results: A total of 16,096 pregnancies were evaluated. Six FMF-trainees and five other ultrasonographers each performed between 83 and 658 NT measurements. For the FMF-trainees, FMF-specific NT-MoM medians were close to one at a crown-rump length (CRL) between 50 and 80 mm, whereas the population-specific NT-MoM medians of the other ultrasonographers were close to one at a CRL between 40 and 80 mm. Performer-specific Delta-NT values fitted a Gaussian distribution between the 5th and 90th percentiles, while for the Log NT-MoM values this was between the 10th and 95th percentiles. Conclusion: We conclude that (i) the use of screening would benefit from performer-specific NT-medians based on Log NT-MoM values; (ii) the use of Log NT-MoM values is marginally better than the use of delta-NT MoMs; and (iii) NT measurements are valid at about 10 weeks (crown-rump length 40–45 mm) as well as at 11–13 weeks.
An analysis of the costs of implementing the National Newborn Hearing Screening Programme in England
Authors: Uus K , Bamford J , Taylor R 
Published: March 2006

Objective: The primary aim of this analysis was to prospectively assess the full economic costs associated with implementing Newborn Hearing Screening Programme (NHSP) based on a two-stage screen, transient evoked otoacoustic emissions followed, if there is no clear response, by automated auditory brainstem response. Economic data were also collected from the Infant Distraction Test Screening (IDTS) service performed by health visitors at around eight months of age, which was being phased out. A comparison of costs and outcomes associated with NHSP and IDTS was conducted. Design: 20 NHSP sites were invited to provide detailed cost data on NHSP implementation and 14 of these sites were selected to provide costs on the IDTS service that was being supplanted. Results: There was marked variability in the costs. Given the higher yield of NHSP sites, the average cost per case detected across NHSP sites (£31,410/case) was approximately half that of IDTS sites (£69,919/case). Including family costs, the average total cost per case of NHSP (£34,826/case) was almost a quarter of IDTS (£117,942/case). Conclusions: Family costs and cost per case associated with NHSP are considerably less than that with IDTS. These findings support the policy of implementation of NHSP and the phasing out of the IDTS.