bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Variation of Drug Dosage on Disease Control and Regional Toxicity in Prophylactic Perfusion for Stage I Extremity Melanoma
Authors: Mikhail Raouf A. , Boddie Arthur W. , Ames Frederick C. , Zimmerman Stuart O. , McBride Charles M. 
Published: February 2007

AbstractOne hundred and fifty‐six patients with extremity melanomas of known level or thickness who were perfused prophylactically with l‐phenylalanine mustard (1‐PAM) between January 1974 and December 1978 were studied retrospectively to determine the effect of variation of drug dosage and temperature on regional toxicity and disease control. The median drug dosage of 1‐PAM for 57 patients undergoing axillary perfusion was 0.85 mg/kg (range 0.48‐1.0 mg/kg) and the median dosage was 1.2 mg/kg (range 0.59‐1.69 mg/kg) for 99 patients undergoing iliac perfusions. Sixty‐five percent of patients achieved a maximum skin temperature of between 101d̀ and 102°F during perfusion. Determinate survival in the entire group was 93% at 5 years; 10% of patients developed positive regional nodes; and 2.5% developed local or intransit metastases. Based on analysis of other series of patients with extremity melanoma with equivalent Clark's level 5‐year determinate survival might be expected to be between 65 and 80%. The expected incidence of nodal metastases should be 19.1‐24.0% and the incidence of local and intransit metastases should be 3‐6%. While this series suggests a survival advantage for a series of extremity melanomas treated by regional chemotherapy when compared to other series treated by wide excision ± regional node dissection, the results obtained were independent of dosage of drug administered or maximal temperature attained over the range studied. This suggests consideration be given to exploring other dose ranges of drugs and heat in an effort to achieve equivalent control with lower regional toxicity.
Plasma cell granuloma of the tonsil
Authors: Weilbaecher Thomas G. , Sarma Deba P. 
Published: February 2007

AbstractPlasma cell granuloma (inflammatory pseudotumor) has been described most commonly in the lung. Review of the English literature fails to reveal occurrence of such a lesion in the tonsil. We are reporting such a case presenting as a unilateral tonsillar mass in a 63‐year‐old man. A more typical case of plasma cell granuloma of lung is also presented to illustrate the similarity between the tonsillar and pulmonary lesions.
Nonfamilial Turcot's syndrome associated with Turner's syndrome, multiple carcinomas of the tongue, and cancer of the colon
Authors: Herrera‐Ornelas Lemuel , Ochi Hisako , Petrelli Nicholas , Mittelman Arnold , Sandberg Avery A. 
Published: February 2007

AbstractHerein we present the clinical and cytogenetic data of a patient with Turner's and Turcot's syndrome associated with multiple carcinomas of the tongue and cancer of the colon.
Pedunculated primary hepatocellular carcinoma
Authors: Cunningham Peter L. , Nava Hector , Lopez Cecilia , Douglass Harold O. 
Published: February 2007

AbstractA case report and two additional cases of pedunculated, primary hepatocellular carcinoma (PHCC) are added to those previously reviewed, and are compared with the more typical presentations of PHCC. Distinct differences include lesser associations with hepatitis B and alpha fetal protein among the pedunculated lesions. More importantly, this unique form of PHCC carries a much higher resectability rate that hopefully can be translated into longer survival in this subgroup.
Surgery for carcinoma of the pancreas and periampullary structures: Complications of resectional and palliative procedures
Authors: Lee Yeu‐Tsu N.(Margaret) 
Published: February 2007

AbstractThis is a retrospective review of 237 patients who had surgical exploration for proven or suspected malignant lesions of the pancreas (201 patients) and periampullary structures (36 patients). Among the former group, 128 patients had carcinoma diagnosed at initial operation (31 by resected specimens, 33 by liver, and 64 by other biopsies), four patients had Whipple resection for suspected carcinoma of pancreas but specimen showed chronic pancreatitis, and 69 patients had suspected carcinoma of the pancreas without histological proof. Among patients who had Whipple resections, the operative mortality was 20%. Over 40% of the deaths was due to systemic complications. Among patients with unresectable lesions, 19% died postoperatively. This figure correlated more with the condition of the host and the extent of the tumor rather than with the specific operative procedures: The operative mortality was 16‐18% for those who had either biliary or duodenal bypass, 11% for those who had both type of bypass procedures, and 36% for those who did not have any bypass performed. Although near 60% of the death was secondary to advanced state of the malignant condition, some death could have been delayed or altered by more optimal biliary, duodenal decompression, and added therapy to decrease gastric acid. In patients with unresectable carcinoma of the head of the pancreas, the most optimal palliative procedures appear to be choledochojejunostomy constructed with a side‐to‐side anastomosis between common or hepatic bile duct and a loop of jejunum, supplemented with an enteroenterostomy below the biliary anastomosis, and a high gastrojejunostomy as a therapeutic or prophylactic treatment of duodenal obstruction.
Dermatofibrosarcoma non‐protuberans: Description and report of five cases of a morpheaform variant of dermatofibrosarcoma
Authors: Clark Lambert W. , Abramovits William , Gonzalez‐Sevra Aldo , Souchon Eduardo , Schwartz Robert A. , Little Walter P. 
Published: February 2007

AbstractFive cases of dermatofibrosarcoma are reported. All showed features typical of dermatofibrosarcoma protuberans except that in four cases, and a portion of the fifth case, no protusion of the tumor was noted clinically despite the rather advanced stage of growth of the tumor. These lesions resembled morphea or a morpheaform basal cell carcinoma clinically but could be recognized as “dermatofibrosarcoma non‐protuberans” by physicians who had observed a previous case.
The continuing problem of carcinoma of the pancreas
Authors: Parker George A. , Postlethwait R. W. 
Published: February 2007

AbstractThe courses of 208 patients with adenocarcinoma of the pancreas were reviewed. The lesion was located in the head of the pancreas in 142 patients, (68%) and of these, in 22 patients the diagnosis was confirmed histologically at postmortem examination; 21 patients underwent laparotomy and biopsy with a 33% operative mortality and 3.4‐month average survival; 89 patients underwent biliary and/or gastric bypass with a 24% mortality and 4.8‐month average survival; 10 patients underwent pancreaticoduodenectomy with a 20% mortality and 14.6‐month average survival. The lesion was located in the body or tail of the pancreas in 77 patients (32%); and, of these, 15 patients had histologic confirmation of clinical diagnoses at postmortem examination; 19 patients underwent biopsy of extra‐abdominal metasases and survived an average of 1.4 months; 27 patients underwent laparotomy and biopsy with a 26% operative mortality and 3.5‐month average survival; 4 patients underwent gastric and/or biliary bypass with a 50% mortality and 4.5‐month average survival; one patient underwent noncurative distal pancreatectomy and survived 1 month postoperatively. No patient was cured of his disease. Of the 55 operative survivors of biliary bypass alone for carcinoma of the head of the pancreas, 5 (9%) required subsequent gastroenterostomy for duodenal obstruction.
Total pelvic exenteration for advanced carcinoma of the lower colon
Authors: Takagi Hiroshi , Morimoto Takeshi , Yasue Mitsunori , Kato Kimiyuki , Yamada Eikichi , Suzuki Ryoji 
Published: February 2007

AbstractThirteen patients with advanced carcinoma of the lower colon and no evidence of extrapelvic metastasis were submitted to total pelvic exenteration. Nine of the 13 patients had ureteral urinary diversion by the ileal segment conduit. Three had colonic conduit bladder using the terminal portion of the descending colon. One patient had bilateral uretero colonic anastomosis. The operative mortality rate was 7.7%. Determinate 5‐year survival rate of 38.5% was achieved. Histological examinations of the surgical specimen revealed associated abcesses adjacent to the tumor in six cases, although the cancer extended to the bowel wall and adhered to the surrounding structures in all specimens. Total pelvic exenteration assures a better quality of life, lessening of symptoms, disease control and, in selected patients, a cure.
Coexistence of aldosteronoma and pheochromocytoma in an adrenal gland
Authors: Wajiki M. , Ogawa A. , Fukui J. , Komiya I. , Yamada T. , Maruyama Y. 
Published: February 2007

AbstractAn extremely rare case is reported in which aldosteronoma and pheochromocytoma coexisted in an adrenal gland. Although the patient presented with clinical features of primary aldosteronism, preoperative examination showed an elevation of both plasma aldosterone and urinary catecholamines. Histology of the removed adrenal gland revealed that, concurrently with a round mass of adrenocortical adenoma, the adrenal medulla was totally occupied by the typical structure of pheochromocytoma.
The steroid hormone receptors in tumors of adipose tissue
Authors: Chaudhuri P. K. , Walker M. J. , Beattie C. W. , Das Gupta T. K. 
Published: February 2007

AbstractThe clinical evidence suggests that the steroid hormones may influence the biologic course of tumors of soft tissue. In an attempt to characterize the possible steroid hormone dependency of soft tissue, we studied the incidence and distribution of cytosolic receptors for the steroid hormones in benign and malignant tumors of adipose tissue origin. All specimens were assayed for the steroid hormone receptors by charcoal dextran technique and analyzed by the method of Scatchard. The results show a high incidence of cytosolic estrogen and glucocorticoid receptors in tumors of adipose tissue origin except in lipoma and well differentiated liposarcoma. The binding parameter of these receptors suggests that the receptors may be responsive to physiologic steroid hormonal milieu.
Thyroid nodules in the irradiated patient—An indication for total thyroidectomy
Authors: Segal Robert L. , Cobin Rhoda H. , Futterweit Walter , Fiedler Robert P. , Sirota David K. 
Published: February 2007

AbstractEight patients who received radiation therapy to the head, neck, or chest during infancy, childhood, or adolescence are reported. In these individuals, the presenting abnormality was a nodule of the thyroid gland, which was found to be benign at surgery. All patients were subsequently found to harbor a malignant lesion of the contralateral lobe. On the basis of this study and the discussion presented, we feel that a total thyroidectomy is the indicated therapeutic procedure in previously radiated patients presenting with a cold nodule.
Postirradiation soft tissue sarcoma occurring in breast cancer patients: Report of seven cases and results of combination chemotherapy
Authors: Kuten Abraham , Sapir Dov , Cohen Yoram , Haim Nissim , Borovik Riva , Robinson Eliezer 
Published: February 2007

AbstractSeven cases of soft tissue sarcoma developing after primary or postoperative radiotherapy for breast carcinoma are reported. The sarcomas occurred within the irradiated volume, after a latent period of 4‐26 years. These cases conform well to established criteria for the diagnosis of radiation‐induced sarcoma. Chemotherapy, consisting of the four‐drug combination CYVAD1C (cyclophosphamide, vincristine, adriamycin, DTIC) was employed in six of the seven patients. Only two of them achieved partial remission, lasting only 2 and 3 months, respectively. The effectiveness of adriamycin‐containing chemotherapy regimens in soft tissue sarcomas as well as the remote hazard of radiation‐related sarcoma in primary or postoperative breast irradiation are discussed.
Amsacrine and etoposide induced paralytic ileus in a patient with acute myelomonocytic leukemia
Authors: Kucuk Omer , Apostol James V. 
Published: February 2007

AbstractA 73‐year‐old man with acute myelomonocytic leukemia developed a severe paralytic ileus after amsacrine and etoposide treatment. The ileus did not respond to treatment with gastric suction and intravenous fluids. Autonomic neuropathy induced by anti‐neoplastic drugs may lead to this life‐threatening condition.
Early recurrence following induction chemotherapy for stage IV head and neck cancers: Rationale for additional therapy
Authors: O'Donnell Margaret R. , Mohr Rose M. , Baxter Donald H. 
Published: February 2007

AbstractTwenty patients with Stage IV neoplasms of the head and neck were treated with two induction cycles of cis‐platinum, bleomycin and metho‐trexate. Eight of eleven operable patients and five of nine inoperable patients responded prior to surgery and/or radiation, including three CRs. Toxicity was mild. There were two early local recurrences but no systemic metastases among the resectable patients. Perhaps initial therapy should be used to select patients with chemoresponsive tumors who might benefit from additional chemotherapy after surgery.
Creatine kinase isoenzyme (CK‐BB) by RIA as a follow‐up marker in stage D cancer of the prostate: Comparison with PAP RIA
Authors: El‐Shribiny Ayda , Bharvaga Arvind , Fitzpatrick John , Murphy Gerald P. 
Published: February 2007

AbstractFifty‐nine patients with stage D carcinoma of the prostate under different modalities of treatment were studied for creatine phosphokinase isoenzyme BB (CK‐BB) and prostatic acid phosphatase (PAP) levels in serum by radioimmunoassay (RIA) technique, in order to study the possible use of CK‐BB as a follow‐up marker compared to PAP. Thirty‐three patients were in stable, 19 in progressive, and seven in regressive clinical state. CK‐BB was above normal level in 52 (88%) out of 59 patients with no statistically significant difference between the three clinical states. On the other hand, PAP was above normal level in only 23 patients (38.98%) with statistically significant difference between the three clinical states (P < 0.001).The PAP/CK‐BB index was below 1 in stable and regressive condition, while it was above 1 in eight out of 19 patients with progressive disease. The PAP/CK‐BB index may be of prognostic importance. CK‐BB by RIA was abnormal in more cases than PAP. In this way CK‐BB reflects the presence of the tumor and may be used for diagnosis; however, it does not reflect the clinical response as PAP does.
Diagnosis and operation for locally recurrent rectal cancer
Authors: Takagi Hiroshi , Morimoto Takeshi , Kato Tomoyuki , Yasue Mitsunori , Hara Suguru , Suzuki Ryoji 
Published: February 2007

AbstractLocal recurrence of rectal cancer following abdominoperineal resection is rarely amenable to limited resection. Six patients with deeply invading recurrent lesions had pelvic exenteration combined with sacral resection. This procedure seems a reasonable treatment for palliation and the chance of cure in selected patients. In order to select good candidates for this extensive procedure, carcinoembryonic antigen (CEA) assays and the diagnosis of locally recurrent tumor with pelvic computed tomography (CT) were evaluated. CEA assay is valuable for diagnosing most recurrent rectal cancers, but it is inadequate for early detection. A high CEA level often indicates extrapelvic tumor spread. CT examination is very valuable for the early detection and localization of recurrence in relation to pelvic structures.
Hemangioendothelioma of the lymph node: A case report
Authors: Goldstein Jed , Bartal N. 
Published: February 2007

AbstractPrimary benign vascular tumors of lymph nodes are very rare. Various forms of lymph nodal vascular transformations defined as hemangiomatoid lesions, pannodal vasodilatation, or nodal anigiomatosis have been described. We present a patient who was thought to have an epithelial salivary gland tumor, but instead was found to have an hemangioendothelioma of an adjacent enlarged lymph node in the region of the left submandibular gland.
Hartmann's pouch carcinoma
Authors: Lafreniere Rene , Ketcham Alrefd S. 
Published: February 2007

AbstractSince 1921, when Henry Hartmann first described his procedure for rectal carcinoma, multiple modifications of the original technique have been proposed. However, the basic principle of a rectal pouch has always been retained. Two cases of carcinoma developing in such a pouch are described; both occurred years after creation of the pouch. One was managed by local resection through a transsacral approach; the other required an abdominoperineal resection. Consideration must be given to careful examination and sigmoidoscopy of these pouches as they tend to be forgotten by the physicians due to their hidden location.
Discrepancy in ER levels of breast carcinoma in biopsy vs mastectomy specimens
Authors: Young Shun C. , Burkett Richard Jerry , Stewart Charles 
Published: February 2007

AbstractThe presence of estrogen receptors (ER) in breast tumors has been used by many as the major indicator for hormonal treatment of breast cancer. However, multiple factors have been shown to be involved in determining the hormone dependence of breast cancer. This paper reports another factor that influences the accuracy of ER determination. From January 1977 through December 1983 fifty‐eight (58) of these patients had ER determination of both biopsy and mastectomy specimens. Of the 31 patients that remained ER positive in mastectomy specimen, 13 had significantly lower ER levels (by at least 50%) from the mastectomy specimens. These findings indicate that ER status is greatly influenced by the source of the specimen.
Calcitonin as a tumor marker for nonthyroid neoplasia
Authors: Hom David , Waxman Kenneth 
Published: February 2007

AbstractPlasma levels of calcitonin have been utilized as a tumor marker for medullary carcinoma of the thyroid. Elevated calcitonin levels have been noted with other tumors as well. The present case documents a marked decrease in calcitonin levels following therapy for breast carcinoma, supporting further evaluation of calcitonin as a clinically useful tumor marker for nonthyroid neoplasm.
Bronchial adenoma: Surgical experience with long‐term follow‐up (4–17 years)
Authors: Halevy Ariel , Schachner Arie , Nili Moshe , Spitzer Shimon , Deviri Ehud , Levy Morris J. 
Published: February 2007

AbstractOf 16 patients with bronchial adenoma who were operated on at Beilinson Medical Center from 1967 to 1980, only three presented the “triad” of cough, hemoptysis, and recurrent pulmonary infections. In two patients the tumor was diagnosed incidentally and in five patients histological evidence of adenoma was made during bronchoscopy. One patient died of myocardial infarction following reoperation for bleeding, and one patient was lost to follow‐up. The remaining 14 patients were followed for 4 to 17 years without evidence of local recurrence or distant metastases.We conclude that the long‐term prognosis of patients with bronchial adenoma is excellent, and limited surgical procedure should be the treatment of choice whenever possible.
Use of 111in‐bleomycin for combining radiotherapy and chemotherapy on glioma‐bearing mice
Authors: Hou De‐Yan , Hoch Hans , Johnston Gerald S. , Tsou K. C. , Farkas Raymond J. , Miller Elizabeth E. 
Published: February 2007

AbstractMice bearing transplanted glioma received 0.9% NaCl, 0.1 mg of BLM, or 200–250 μCi of 111 In‐BLM (0.1 mg BLM) daily for 5 days intraperitoneally. After therapy, tumor sizes were in the order NaCl > BLM > 111 In‐BLM. On the 11th day after the first injection, tumor size (mm3) in the 111 In‐BLM group was 1,220; in the BLM group, it was 2,310 (P < .025). After intratumor injection of a total dose of 0.1 mg of BLM/gm tumor weight, or of 1 mCi/gm tumor weight of 111 In‐BLM (carried by 0.1 mg of BLM/gm tumor weight), the tumor size decreased in the 111 In‐BLM group more than in the BLM group. On the 5th day after the 2nd dose therapy, the tumor size in the 111 In‐BLM group was 2,020; in the BLM group it was 4,220 (P < .05). Host weights for these two groups were similar. The necrotic area in the tumor was much greater in the 111 In‐BLM group than in the BLM group. These results suggest the use for radiotherapy and chemotherapy.
Variability of heating patterns in animals by magnetic induction hyperthermia
Authors: Storm F. Kristian , Christensen Douglas A. , Olch Arthur J. , Silberman Allan W. , Roe Denise J. , Harrison William H. , Elliott Robert S. , Morton Donald L. 
Published: February 2007

AbstractIn a test of electromagnetic induction hyperthermia to deep viscera of a live dog model, we found that heating was not uniform to any depth, but was quite variable. In general, there was a thermal gradient between peripheral and central portions of the transposed spleen of about 1°C. Though heat generation within the abdomen was not uniform, its temperature pattern in the alive animal resulted in significant heating of that part of the organ that had been surgically placed at the center of the animal. This heating could not be explained by perfusion with regionally heated core blood. Our results indicate that extensive investigations in living systems and complex dynamic phantoms will be necessary before individual patient response can be predicted.
Carcinoma arising in burn scar
Authors: Sarma Deba P. , Weilbaecher Thomas G. 
Published: February 2007

AbstractA 60‐year‐old man had undergone a left below‐knee amputation 30 years ago owing to trauma and burn suffered in a dynamite explosion. He has been wearing an artificial leg since then. He developed a squamous cell carcinoma on the amputation stump 30 years later. The possible relationship of the burn scar and chronic irritation by the artificial leg to the cancer is discussed.
Adrenal adenocarcinomas: Histologic grading and survival
Authors: Karakousis C. P. , Rao U. , Moore R. 
Published: February 2007

AbstractThirty‐eight patients with adrenal adenocarcinoma were reviewed. Two of 23 males and 8 of 15 females had a functioning tumor (P < 0.005). The most striking finding in this review was the variation in survival according to histologic grade. The median survival from histologic diagnosis was for grade I tumors 54 months, for grade II tumors 26 months, for grade III tumors 1 month. The difference in survival between patients with grade I or II tumors and those with grade III tumors was significant (P < 0.001). The majority of the patients with grade III tumors were admitted with clinical evidence of disseminated disease and died within 1 month. Among the patients with well‐differentiated tumors, five who received surgical treatment of their recurrence had a median survival of 51 months, whereas seven patients who received no surgical treatment had median survival of 20 months following first recurrence (0.05 < P < 0.10).
Identical laryngeal cancers in two nontwin sibling pairs: Case reports and a review of the literature
Authors: Sener Stephen F. , Spiro Ronald H. , Shah Jatin P. 
Published: February 2007

AbstractThe occurrence of identical laryngeal cancers in two nontwin sibling pairs is reported for the first time. To understand the relative importance of genetic and environmental factors in the etiology of laryngeal cancer, the evidence in the literature for the development of identical cancers in genetically unrelated and related pairs sharing the same environments was examined.