bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comprehensive analysis of Salmonella in poultry meat and products in Türkiye: Prevalence, antibiotic susceptibility and genomic characterisation
Authors: Dishan Adalet , Hizlisoy Harun , Onmaz Nurhan Ertaş , Yildirim Yeliz , Gonulalan Zafer , Al Serhat 
Published: March 2024

SummaryThe study aimed to determine the prevalence and characteristics of Salmonella isolated from raw chicken meat and products. For this purpose, a total of 293 samples were collected, including chicken breast (n = 90), skinned drumstick (n = 80), skinned chicken chop (n = 42), wing (n = 32), chicken offal (n = 27) and chicken patty (n = 22). The samples were subjected to Salmonella enterica. detection and the obtained suspicious isolates were confirmed by conventional PCR. Their phenotypical antibiotic resistance profiles were subsequently determined. The prevalence of Salmonella Enteritidis and Typhimurium serovars among S. enterica isolates were investigated using TaqMan probe Real‐Time PCR (qPCR) analysis, and the detected serovars were evaluated with whole genome sequencing. In the study, 112 (38.22%) of the 293 chicken samples contained S. enterica, with five (4.46%) and one (0.89%) of the isolates identified as Salmonella Enteritidis and Typhimurium, respectively. Antibiotic resistance analysis revealed that all isolates were sensitive to Meropenem and Aztreonam, while the most resistant antibiotics were Doxycycline (96.42%) and Trimethoprim‐sulfamethoxazole (71.42%). Whole genome sequencing, specifically SNP‐based phylogenetic analyses, indicated that Salmonella Enteritidis and Typhimurium isolates were distinct clones. All Salmonella Enteritidis isolates shared the same antigenic profiles (9: g, m:‐) and cgMLST types of 11, while the Salmonella Typhimurium isolate had cgMLST type 19 and a 4:i:1,2 antigenic profile. It was observed that the phenotypic resistance profiles of the isolates were consistent with the whole genome characterisation. The data obtained in the study reveal the continued importance of Salmonella monitoring for the poultry industry across different regions of Türkiye to maintain food safety. Chicken meat and products are indispensable to public health in providing healthy nutrition and access to animal protein. The microbiological and epidemiological risks observed in mass production can be minimised, particularly by integrating epidemiological and molecular findings with an effective strategy.
Proximity to Bank Headquarters and Branch Efficiency: Evidence from Mortgage Lending
Authors: LIM IVAN , NGUYEN DUC DUY , NGUYEN LINH , WILSON JOHN O.S. 
Published: March 2024

AbstractWe use the staggered introduction of new flight routes to identify reductions in travel time between banks’ headquarters and branches to examine their effects on branch outputs and efficiency. Reductions in headquarters–branch travel time increases branch‐level mortgage origination volume, and these loans exhibit higher ex post performance. Further analyses suggest these effects are due to branch employees working harder and more efficiently in seeking new customers and screening applications. Overall, our results imply that geographic proximity enables bank headquarters to monitor branches more effectively and mitigate distance‐related agency costs.
Infiltration of immune cells to the brain and its relation to the pathogenesis of Alzheimer's and Parkinson's diseases
Authors: Netzahualcoyotzi Citlalli , Santillán‐Cigales Juan Jair , Adalid‐Peralta Laura Virginia , Velasco Iván 
Published: March 2024

AbstractThe neurovascular unit, composed of vascular endothelium, vascular smooth muscle, extracellular matrix components, pericytes, astrocytes, microglia, and neurons, allows the highly regulated exchange of molecules and the limited trafficking of cells to the brain through coordinated signaling activity. The passage of peripheral immune cells to the brain parenchyma is observed when there is clear damage to the barriers of this neurovascular unit, as occurs in traumatic brain injury. The possibility of leukocyte infiltration to the brain in neurodegenerative conditions has been proposed. In this review, we focus on describing the evidence for peripheral immune cell infiltration to the brain in the two most frequent neurodegenerative diseases: Alzheimer's and Parkinson's diseases. In particular, we address the mechanisms that promote the passage of these cells into the brain under such pathological conditions. We also discuss the relevance of the resulting cellular interactions, which provide evidence that the presence of peripheral immune cells in the brain is a key point in these neurodegenerative diseases.image
Geographic distribution, prevalence, and incidence of citrus black spot caused by Phyllosticta citricarpa in Tunisia
Authors: Benfradj Najwa , Mannai Sabrine , Jeandel Céline , Boughalleb‐M'Hamdi Naima 
Published: March 2024

AbstractCitrus black spot (CBS), caused by Phyllosticta citricarpa, is an important disease of citrus, an economically important fruit crop worldwide and particularly in Tunisia. CBS was recently detected in Tunisia and this study revealed that it is widespread in the governorates of Nabeul and Sousse. The highest incidence of CBS was found in the Bouargoub region (73.7%), while the lowest was observed in Soliman (25.0%) in the Nabeul governorate. The surveys revealed that CBS affected mainly lemon (Citrus limon). The symptoms of CBS observed were hard spots on fruits, twigs, and leaves, as well as false melanose on fruits. Symptoms were observed in both mature and immature citrus fruits, but disease incidence was higher in mature (97.0%) than that in immature fruits (2.95%). In this study, morphological and molecular identifications confirmed the presence of P. citricarpa. This is the first time that the extent of CBS has been documented in a Mediterranean citrus area.
Tobacco products and oral conditions among US adults: NHANES 2017–2020
Authors: Alamer Nora I. , Alsaleh Ahmed , Alkhaldi Sultan 
Published: March 2024

AbstractObjectivesSmoking is a major global health problem with serious systemic and oral consequences. This study aims at assessing the influence of smoking cigarettes and other types of smoked tobacco on oral conditions (OCs) using a representative sample of US adults.MethodsPre‐pandemic data from the National Health and Nutrition Examination Survey 2017–2020 were utilized, and 7840 adults aged ≥30 years were included in our analyses. Descriptive statistics, logistic, and negative binomial regression models were performed to assess the relationship between tobacco products and OCs including, tooth loss (TL), coronal (CC) and root caries (RC).ResultsOverall, 16.29% of our sample were current cigarette smokers (CCS). TL (17.25%) and untreated RC (28.26%) were more evident among CCS. In the adjusted regression models, smoking cigarettes was associated with RC (AOR: 3.20, 95% CI; 2.02, 5.09), untreated CC (IRR: 3.08, 95% CI: 1.50, 6.31), and TL (IRR: 2.18, 95% CI: 1.64, 2.88). Regarding the type of used tobacco product in the past 5 days, cigarettes were the most common type (15.03%). The adjusted model indicated that e‐cigarette smokers had the highest odds of untreated RC (AOR: 5.17, 95% CI: 2.19, 12.23) and the highest rate of TL (IRR: 2.21, 95% CI: 1.45, 3.35). Further, cigar smokers had the highest rate of teeth with untreated CC (IRR: 3.25, 95% CI: 1.46, 7.25).ConclusionsUsing tobacco products is associated with poor OCs. Dentists, being the primary oral health care providers, can play a crucial role in counseling and supporting smokers to quit as part of their routine dental examination.
The effects of cyflumetofen on life history traits and population parameters of Amblyseius swirskii</p >
Authors: Havasi Mohammadreza , Kheradmand Katayoon 
Published: March 2024

Even as new chemical substances show promise as selectivity for controlling pests due to their high effectiveness in inhibiting pests, their side effects on non-target organisms must nevertheless be evaluated before they can be included in integrated pest management systems. We examined both lethal and sublethal (LC10 and LC30) effects of cyflumetofen on the predatory potential of the Amblyseius swirskii Athias Henriot (Acari: Phytoseiidae) which is among the most dominant mite predators in tropical agricultural agroecosystems. The experiments were performed under laboratory conditions at 25 ± 2°C, 65 ± 5% relative humidity (RH), and a photoperiod of 16:8 (L: D) hours. Results were analyzed based on age-stage, two-sex life table analysis. The data showed that sublethal concentrations of the pesticides suppress fecundity, total life span (both female and male individuals), and the intrinsic and finite rate of increase significantly. The result show, the fecundity in the LC10, LC30, and control was 14.97, 11.87, and 17.28, eggs/female for LC10 and LC30, respectively, showing significant differences. The values of the intrinsic rate of increase (r) on the above-mentioned concentrations were 0.1333, 0.1166, and 0.1430 day-1, respectively. Consequently, according to the data, it seems that the selected acaricide is not suitable to use with A. swiriskii in integrated pest management programs due to their unfavorable effects on the population parameters of this predatory mite.
Impact of an Impaired Maternal–Fetal Environment on Death in Children With Congenital Heart Defects Undergoing Surgery in Denmark From 1994 to 2018
Authors: Kristensen Rasmus , Omann Camilla , Ekelund Charlotte K. , Gaynor J. William , Hjortdal Vibeke E. 
Published: March 2024

Background
Studies show that an impaired maternal–fetal environment (iMFE) increases the mortality risk in children with single‐ventricle congenital heart defects (CHDs). We investigated the impact of an iMFE on death in children with various surgically corrected CHDs.

Methods and Results
In this nationwide register‐based study, we examined the association between an iMFE (including preeclampsia, gestational hypertension, gestational diabetes, maternal smoking during pregnancy) and death in a large cohort of children with surgically corrected CHDs in Denmark (1994–2018). Survival analysis was done using Cox regression, adjusted for confounding and mediating covariates. The cohort included 3304 children: 1662 (50.3%) with minor CHD and 1642 (49.7%) with major CHD. Among them, 792 (24%) children were exposed to an iMFE. During the study, there were 290 deaths: 71 (9.3%) in children exposed to an iMFE and 219 (8.7%) in those unexposed.

There were no differences in mortality risk between children with CHD exposed to an iMFE and those unexposed (hazard ratio [HR], 1.12 [95% CI, 0.86–1.47];
P
=0.4). This was consistent across subgroups, including minor CHD (HR, 0.76 [95% CI, 0.39–1.47];
P
=0.4), major CHD (HR, 1.23 [95% CI, 0.92–1.64];
P
=0.2), and hypoplastic left heart syndrome/univentricular heart (HR, 1.08 [95% CI, 0.64–1.85];
P
=0.8).

Conclusions
Impairment of the maternal–fetal environment did not impact the mortality rate in children with CHD undergoing operation in Denmark from 1994 to 2018. We believe the cause of these discrepant findings to previous studies may be due to differences in the composition of CHD and prenatal maternal health care and health status of the population.
Representation of Real‐World Adults With Chronic Kidney Disease in Clinical Trials Supporting Blood Pressure Treatment Targets
Authors: Li June , An Jaejin , Huang Mengjiao , Zhou Mengnan , Montez‐Rath Maria E. , Niu Fang , Sim John J. , Pao Alan C. , Charu Vivek , Odden Michelle C. , Kurella Tamura Manjula 
Published: March 2024

Background
Little is known about how well trial participants with chronic kidney disease (CKD) represent real‐world adults with CKD. We assessed the population representativeness of clinical trials supporting the 2021 Kidney Disease: Improving Global Outcomes blood pressure (BP) guidelines in real‐world adults with CKD.

Methods and Results
Using a cross‐sectional analysis, we identified patients with CKD who met the guideline definition of hypertension based on use of antihypertensive medications or sustained systolic BP ≥120 mm Hg in 2019 in the Veterans Affairs and Kaiser Permanente of Southern California. We applied the eligibility criteria from 3 BP target trials, SPRINT (Systolic Pressure Intervention Trial), ACCORD (Action to Control Cardiovascular Risk in Diabetes), and AASK (African American Study of Kidney Disease), to estimate the proportion of adults with a systolic BP above the guideline‐recommended target and the proportion who met eligibility criteria for ≥1 trial. We identified 503 480 adults in the Veterans Affairs and 73 412 adults in Kaiser Permanente of Southern California with CKD and hypertension in 2019. We estimated 79.7% in the Veterans Affairs and 87.3% in the Kaiser Permanente of Southern California populations had a systolic BP ≥120 mm Hg; only 23.8% [23.7%–24.0%] in the Veterans Affairs and 20.8% [20.5%–21.1%] in Kaiser Permanente of Southern California were trial‐eligible. Among trial‐ineligible patients, >50% met >1 exclusion criteria.

Conclusions
Major BP target trials were representative of fewer than 1 in 4 real‐world adults with CKD and hypertension. A large proportion of adults who are at risk for cardiovascular morbidity from hypertension and susceptible to adverse treatment effects lack relevant treatment information.
Statin Twitter: Human and Automated Bot Contributions, 2010 to 2022
Authors: Slavin Samuel D. , Berman Adam N. , Beam Andrew L. , Navar Ann Marie , Mittleman Murray A. 
Published: March 2024

BackgroundMany individuals eligible for statin therapy decline treatment, often due to fear of adverse effects. Misinformation about statins is common and drives statin reluctance, but its prevalence on social media platforms, such as Twitter (now X) remains unclear. Social media bots are known to proliferate medical misinformation, but their involvement in statin‐related discourse is unknown. This study examined temporal trends in volume, author type (bot or human), and sentiment of statin‐related Twitter posts (tweets).Methods and ResultsWe analyzed original tweets with statin‐related terms from 2010 to 2022 using a machine learning–derived classifier to determine the author's bot probability, natural language processing to assign each tweet a negative or positive sentiment, and manual qualitative analysis to identify statin skepticism in a random sample of all tweets and in highly influential tweets. We identified 1 155 735 original statin‐related tweets. Bots produced 333 689 (28.9%), humans produced 699 876 (60.6%), and intermediate probability accounts produced 104 966 (9.1%). Over time, the proportion of bot tweets decreased from 47.8% to 11.3%, and human tweets increased from 43.6% to 79.8%. The proportion of negative‐sentiment tweets increased from 27.8% to 43.4% for bots and 30.9% to 38.4% for humans. Manually coded statin skepticism increased from 8.0% to 19.0% for bots and from 26.0% to 40.0% for humans.ConclusionsOver the past decade, humans have overtaken bots as generators of statin‐related content on Twitter. Negative sentiment and statin skepticism have increased across all user types. Twitter may be an important forum to combat statin‐related misinformation.
Risk Score for Prediction of Dialysis After Transcatheter Aortic Valve Replacement
Authors: Pasceri Vincenzo , Pelliccia Francesco , Mehran Roxana , Dangas George , Porto Italo , Radico Francesco , Biancari Fausto , D'Ascenzo Fabrizio , Saia Francesco , Luzi Giampaolo , Bedogni Francesco , Amat Santos Ignacio J. , De Marzo Vincenzo , Dimagli Arnaldo , Mäkikallio Timo , Stabile Eugenio , Blasco‐Turrión Sara , Testa Luca , Barbanti Marco , Tamburino Corrado , Fabiocchi Franco , Chilmeran Ahmed , Conrotto Federico , Costa Giuliano , Stefanini Giulio , Spaccarotella Carmen , Macchione Andrea , La Torre Michele , Bendandi Francesco , Juvonen Tatu , Wańha Wojciech , Wojakowski Wojtek , Benedetto Umberto , Indolfi Ciro , Hildick‐Smith David , Zimarino Marco 
Published: March 2024

Background
Dialysis is a rare but serious complication after transcatheter aortic valve replacement. We analyzed the large multicenter TRITAVI (transfusion requirements in transcatheter aortic valve implantation) registry in order to develop and validate a clinical score assessing this risk.

Methods and Results

A total of 10 071 consecutive patients were enrolled in 19 European centers. Patients were randomly assigned (2:1) to a derivation and validation cohort. Two scores were developed, 1 including only preprocedural variables (TRITAVIpre) and 1 also including procedural variables (TRITAVIpost). In the 6714 patients of the derivation cohort (age 82±6 years, 48% men), preprocedural factors independently associated with dialysis and included in the TRITAVIpre score were male sex, diabetes, prior coronary artery bypass graft, anemia, nonfemoral access, and creatinine clearance <30 mL/min per m
2
. Additional independent predictors among procedural features were volume of contrast, need for transfusion, and major vascular complications. Both scores showed a good discrimination power for identifying risk for dialysis with C‐statistic 0.78 for TRITAVIpre and C‐statistic 0.88 for TRITAVIpost score. Need for dialysis increased from the lowest to the highest of 3 risk score groups (from 0.3% to 3.9% for TRITAVIpre score and from 0.1% to 6.2% for TRITAVIpost score). Analysis of the 3357 patients of the validation cohort (age 82±7 years, 48% men) confirmed the good discrimination power of both scores (C‐statistic 0.80 for TRITAVIpre and 0.81 for TRITAVIpost score). Need for dialysis was associated with a significant increase in 1‐year mortality (from 6.9% to 54.4%;
P
=0.0001).

Conclusions
A simple preprocedural clinical score can help predict the risk of dialysis after transcatheter aortic valve replacement.
Baseline Uric Acid Levels and Intravenous Thrombolysis Outcomes in Patients With Acute Ischemic Stroke: A Prospective Cohort Study
Authors: Zhang Peng , Wang Rui , Guo Zhen‐Ni , Jin Hang , Qu Yang , Zhen Qing , Yang Yi 
Published: March 2024

Background
The study aimed to investigate the relationship between uric acid (UA) levels and functional outcomes at 3 months in patients with acute ischemic stroke (AIS) who underwent intravenous thrombolysis (IVT).

Methods and Results

This prospective cohort study included 1001 consecutive patients with AIS who underwent IVT. The correlation between UA levels and post‐IVT AIS outcomes was examined. Any nonlinear relationship was assessed using a restricted cubic spline function. The nonlinear
P
value for the association of UA levels with favorable (modified Rankin Scale [mRS] score ≤2) and excellent (mRS score ≤1) outcomes at 3 months post‐IVT were <0.001 and 0.001, respectively. However, for patients with and without hyperuricemia, no evident nonlinear relationship was observed between UA levels and favorable 3‐month post‐IVT outcomes, with nonlinear
P
values of 0.299 and 0.207, respectively. The corresponding interaction analysis yielded a
P
value of 0.001, indicating significant heterogeneity. Similar results were obtained for excellent outcomes at 3 months post‐IVT. In the hyperuricemia group, increased UA levels by 50 μmol/L reduced the odds of a favorable 3‐month post‐AIS outcome (odds ratio [OR], 0.75 [95% CI, 0.57–0.97]). Conversely, in the nonhyperuricemia group, a similar UA increase was linked to higher favorable outcome odds (OR, 1.31 [95% CI, 1.15–1.50]).

Conclusions
An inverted U‐shaped nonlinear relationship was observed between UA levels and favorable and excellent outcomes at 3 months in patients with AIS who underwent IVT. Higher UA levels predict favorable outcomes in patients without hyperuricemia but unfavorable outcomes in those with hyperuricemia.
RV1+RV3 Index to Differentiate Idiopathic Ventricular Arrhythmias Arising From Right Ventricular Outflow Tract and Aortic Sinus of Valsalva: A Multicenter Study
Authors: Chen Ning , Wang Lei , Jiao Jincheng , Ju Weizhu , Wang Zhe , Zou Cao , Yi Fu , Xiao Fangyi , Shen Wenzhi , Li Chengzong , Shi Linsheng , Chen Long , Ji Yuan , Wei Youquan , Gu Kai , Yang Gang , Chen Hongwu , Li Mingfang , Liu Hailei , Chen Minglong 
Published: March 2024

Background
This study aimed to investigate the predictive value of parameters of every precordial lead and their combinations in differentiating between idiopathic ventricular arrhythmias (IVAs) from the right ventricular outflow tract and aortic sinus of Valsalva (ASV).

Methods and Results
Between March 1, 2018, and December 1, 2021, consecutive patients receiving successful ablation of right ventricular outflow tract or ASV IVAs were enrolled. The amplitude and duration of the R wave and S wave were measured in every precordial lead during IVAs. These parameters were either summed, subtracted, multiplied, or divided to create different indexes. The index with the highest area under the curve to predict ASV IVAs was developed, compared with established indexes, and validated in an independent prospective multicenter cohort. A total of 150 patients (60 men; mean age, 45.3±16.4 years) were included in the derivation cohort. The RV1+RV3 index (summed R‐wave amplitude in leads V1 and V3) had the highest area under the curve (0.942) among the established indexes. An RV1+RV3 index >1.3 mV could predict ASV IVAs with a sensitivity of 95% and a specificity of 83%. Its predictive performance was maintained in the validation cohort (N=109). In patients with V3 R/S transition, an RV1+RV3 index >1.3 mV could predict ASV IVAs, with an area under the curve of 0.892, 93% sensitivity, and 75% specificity.

Conclusions
The RV1+RV3 index is a simple and novel criterion that accurately differentiates between right ventricular outflow tract and ASV IVAs. Its performance outperformed established indexes, making it a valuable tool in clinical practice.
Shared Genetic Features of Psoriasis and Myocardial Infarction: Insights From a Weighted Gene Coexpression Network Analysis
Authors: Zhou Qiaoyu , Shi Ruizheng 
Published: March 2024

Background
Increasing evidence suggests a higher propensity for acute myocardial infarction (MI) in patients with psoriasis. However, the shared mechanisms underlying this comorbidity in these patients remain unclear. This study aimed to explore the shared genetic features of psoriasis and MI and to identify potential biomarkers indicating their coexistence.

Methods and Results
Data sets obtained from the gene expression omnibus were examined using a weighted gene coexpression network analysis approach. Hub genes were identified using coexpression modules and validated in other data sets and through in vitro cellular experiments. Bioinformatics tools, including the Human microRNA Disease Database, StarBase, and miRNet databases, were used to construct a ceRNA network and predict potential regulatory mechanisms. By applying weighted gene coexpression network analysis, we identified 2 distinct modules that were significant for both MI and psoriasis. Inflammatory and immune pathways were highlighted by gene ontology enrichment analysis of the overlapping genes. Three pivotal genes—Src homology and collagen 1, disruptor of telomeric silencing 1‐like, and feline leukemia virus subgroup C cellular receptor family member 2—were identified as potential biomarkers. We constructed a ceRNA network that suggested the upstream regulatory roles of these genes in the coexistence of psoriasis and MI.

Conclusions
As potential therapeutic targets, Src homology and collagen 1, feline leukemia virus subgroup C cellular receptor family member 2, and disruptor of telomeric silencing 1‐like provide novel insights into the shared genetic features between psoriasis and MI. This study paves the way for future studies focusing on the prevention of MI in patients with psoriasis.