bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanotherapy: how physical therapists’ prescription of exercise promotes tissue repair
Authors: Khan K M , Scott A 
Published: February 2009

Mechanotransduction is the physiological process where cells sense and respond to mechanical loads. This paper reclaims the term “mechanotherapy” and presents the current scientific knowledge underpinning how load may be used therapeutically to stimulate tissue repair and remodelling in tendon, muscle, cartilage and bone.The purpose of this short article is to answer a frequently asked question “How precisely does exercise promote tissue healing?” This is a fundamental question for clinicians who prescribe exercise for tendinopathies, muscle tears, non-inflammatory arthropathies and even controlled loading after fractures. High-quality randomised controlled trials and systematic reviews show that various forms of exercise or movement prescription benefit patients with a wide range of musculoskeletal problems.1–4 But what happens at the tissue level to promote repair and remodelling of tendon, muscle, articular cartilage and bone?The one-word answer is “mechanotransduction”, but rather than finishing there and limiting this paper to 95 words, we provide a short illustrated introduction to this remarkable, ubiquitous, non-neural, physiological process. We also re-introduce the term “mechanotherapy” to distinguish therapeutics (exercise prescription specifically to treat injuries) from the homeostatic role of mechanotransduction. Strictly speaking, mechanotransduction maintains normal musculoskeletal structures in the absence of injury. After first outlining the process of mechanotransduction, we provide well-known clinical therapeutic examples of mechanotherapy–turning movement into tissue healing.
HADRONIC INTERACTIONS AT THE CERN SPS: RESONANCE DECAYS VERSUS PARTON DYNAMICS
Authors: RYBICKI ANDRZEJ 
Published: February 2009

Using new data on pion production in p + p interactions from the NA49 experiment, it is demonstrated that the detailed features of double differential pion cross sections are well reproduced over most of the phase space from the decay of a representative sample of known mesonic and baryonic resonances. Thirteen resonances reaching up to spin four tensor-mesons and including the newly measured N * states up to the N *(1680) have been used. The pT integrated Feynman xF distributions in the high-xF region 0.4 < xF < 0.9 are quantitatively reproduced as well as the pT distributions up to 2 GeV/c and beyond at all xF. In both these phase space regions direct effects of parton dynamics such as valence quark fragmentation or parton scattering are generally evoked in order to provide a basis of understanding. The saturation of the measured yields by resonance decay casts a doubt on these assumptions.
NEW PARAMETERIZATION OF THE RESONANT PRODUCTION AMPLITUDES NEAR AN INELASTIC THRESHOLD
Authors: LEŚNIAK LEONARD 
Published: February 2009

New formulae for the resonant scattering and the production amplitudes near an inelastic threshold are derived. It is shown that the Flatté formula, frequently used in experimental analyses, is not sufficiently accurate. Its application to data analysis can lead to a substantial distortion of the effective mass spectra and of the resonance pole positions. A unitary parameterization, satisfying a generalized Watson theorem for the production amplitudes, is proposed. It can be easily applied to study production processes, multichannel meson-meson interactions and the resonance properties, including among others the scalar resonances a0(980) and f0(980).
A NEW CHARACTERIZATION OF U4(7) BY ITS NONCOMMUTING GRAPH
Authors: ZHANG LIANGCAI , SHI WUJIE 
Published: February 2009

Let G be a finite nonabelian group and associate a disoriented noncommuting graph ∇(G) with G as follows: the vertex set of ∇(G) is G\Z(G) with two vertices x and y joined by an edge whenever the commutator of x and y is not the identity. In 1987, J. G. Thompson gave the following conjecture.Thompson's Conjecture If G is a finite group with Z(G) = 1 and M is a nonabelian simple group satisfying N(G) = N(M), then G ≅ M, where N(G) denotes the set of the sizes of the conjugacy classes of G.In 2006, A. Abdollahi, S. Akbari and H. R. Maimani put forward a conjecture in [1] as follows.AAM's Conjecture Let M be a finite nonabelian simple group and G a group such that ∇(G)≅ ∇ (M). Then G ≅ M.Even though both of the two conjectures are known to be true for all finite simple groups with nonconnected prime graphs, it is still unknown for almost all simple groups with connected prime graphs. In the present paper, we prove that the second conjecture is true for the projective special unitary simple group U4(7).
Picturing Victory The Visual Imaginary of the War of Resistance, 1937–1947
Authors: Mitter Rana 
Published: February 2009

AbstractThe Sino-Japanese War of 1937–1947 has not been sufficiently understood as a narrative in its own right, but rather, as a transitional conflict between Nationalist and Communist rule. The examination of the visual imagery of warfare disseminated through newsprint and books is one way to reinterpret the history of this period. Through a close reading of images printed in a Shanghai newspaper, Zhonghua ribao, during the final days of the battle for the city in 1937, we see how the news was shaped to impose a narrative of order with a positive teleology at a time when China was plunged into chaos with no guarantee of the eventual outcome of the war. The nature of this narrative is explored through examination of images of the body, as well as the positioning of images in the context of the printed page. The conclusion then contrasts these images with a pictorial history of the Sino-Japanese War published during the Civil War, in 1947. It suggests that although this book is able to bring narrative closure to the earlier conflict, its own narrative is imbued with an unease caused by the reality of the new war that had broken out within months of the ending of the war against Japan, and suggests that narrative closure is never truly obtained.
Regulatory T cells differentially modulate the maturation and apoptosis of human CD8+ T-cell subsets
Authors: Nikolova Maria , Lelievre Jean-Daniel , Carriere Matthieu , Bensussan Armand , Lévy Yves 
Published: February 2009

AbstractThe balanced manifestation of effector functions and the generation of long-living memory cells is a hallmark of efficient CD8+ T-cell response. Accumulating data pinpoint CD4+ CD25high regulatory T (Treg) cells as a key factor for the inefficiency of CD8+ T-cell responses in viral persistence. Little is known about the effects of Treg cells on the homeostasis of healthy donor CD8+ T cells. The present study demonstrates that Treg cells exert differential effects on CD8+ T-cell subsets. Treg cells inhibited mostly the polyclonal proliferation of CD27− effector cells compared with CD27+ memory CD8+ T cells. Moreover, they inhibited the polyclonal and antigen-driven differentiation of memory cells into functional effectors as defined by IFN-γ secretion and induction of CD160 expression. Finally, Treg cells reduced the apoptosis of memory but not of effector and terminal effector cell populations. These effects were at least in part mediated by a decreased expression of PD-L1, but not of programmed death 1 (PD-1), on CD8+ T cells after activation. Thus, in the setting of a healthy immune system, Treg cells fine-tune the memory/effector cell balance and promote the accumulation of long-living memory cells in case of strong stimulation.
Novel function for interleukin-7 in dendritic cell development
Authors: Vogt Tobias K. , Link Alexander , Perrin John , Finke Daniela , Luther Sanjiv A. 
Published: February 2009

Abstract
Interleukin-7 (IL-7) is crucial for the development of T and B lymphocytes from common lymphoid progenitors (CLPs) and for the maintenance of mature T lymphocytes. Its in vivo role for dendritic cells (DCs) has been poorly defined. Here, we investigated whether IL-7 is important for the development or maintenance of different DC types. Bone marrow–derived DCs expressed the IL-7 receptor (IL-7R) and survived significantly longer in the presence of IL-7. Migratory DCs (migDCs) isolated from lymph nodes also expressed IL-7R. Surprisingly, IL-7R was not required for their maintenance but indirectly for their development. Conventional DCs (cDCs) and plasmacytoid DCs (pDCs) resident in lymph nodes and spleen were IL-7R−. Using mixed bone marrow chimeras, we observed an intrinsic requirement for IL-7R signals in their development. As the number of CLPs but not myeloid progenitors was reduced in the absence of IL-7 signals, we propose that a large fraction of cDCs and pDCs derives from CLPs and shares not only the lymphoid origin but also the IL-7 requirement with lymphocyte precursors.
Induction of apoptosis by the retinoid inducible growth regulator RIG1 depends on the NC motif in HtTA cervical cancer cells
Authors: Tsai Fu-Ming , Shyu Rong-Yaun , Lin Su-Ching , Wu Chang-Chieh , Jiang Shun-Yuan 
Published: February 2009

Abstract

Background
Retinoid-inducible gene 1 (RIG1), also known as tazarotene-induced gene 3 or retinoic-acid receptor responder 3, is a growth regulator, which induces apoptosis and differentiation. RIG1 is classified into the NC protein family. This study investigated functional domains and critical amino acids associated with RIG1-mediated cell death and apoptosis.

Results
Using enhanced green fluorescence protein (EGFP)-tagged RIG1 variants, RIG1 proteins with deletion at the NC domain significantly decreased cell death induced by RIG1, and fusion variants containing only the NC domain significantly induced apoptosis of HtTA cervical cancer cells. The EGFP-RIG1-induced apoptosis was significantly decreased in cells expressing N112C113 motif double- (NC→FG) or triple- (NCR→FGE) mutated RIG1 variants. Using dodecapeptides, nuclear localization and profound cell death was observed in HtTA cells expressing wild type RIG1111–123 or Leu121-mutated RIG1111–123:L→ C peptide, but peptides double- or triple-mutated at the NC motif alone, RIG1111–123:NC→FG or RIG1111–123:NCR→FGE, were cytoplasmically localized and did not induce apoptosis. The RIG1111–123 also induced apoptosis of A2058 melanoma cells but not normal human fibroblasts.

Conclusion
The NC domain, especially the NC motif, plays the major role in RIG1-mediated pro-apoptotic activity. The RIG1111–123 dodecapeptide exhibited strong pro-apoptotic activity and has potential as an anticancer drug.
Toothache and associated factors in Brazilian adults: a cross-sectional population-based study
Authors: Kuhnen Mirian , Peres Marco A , Masiero Anelise V , Peres Karen G 
Published: February 2009

Abstract

Background
Toothache is a dental public health problem and one of the predictors of dental attendance and it is strongly associated with the life quality of individuals. In spite of this, there are few population-based epidemiological studies on this theme. Objective: To estimate the prevalence of toothache and associated factors in adults of Lages, Southern Brazil.

Methods
A cross-sectional population-based study was carried out in a sample of 2,022 adults aged 20 to 59 years living in the urban area of a medium sized city in Southern Brazil. A questionnaire including socioeconomic, demographic, smoking, alcohol, and use of dental service variables was applied at adults household. Toothache occurred six months previous of the interview was considered the outcome. Poisson regression analyses were performed following a theoretical hierarchical framework. All analysis was adjusted by the sample design effect.

Results
The response rate was 98.6%. The prevalence of toothache was 18.0% (95% CI 16.0; 20.1). The following variables were associated with toothache after adjustment: female (PR = 1.3 95% CI 1.3; 2.0), black skin colour vs. whites (PR = 1.5 95% CI 1.1, 1.9), low per capita income (PR = 1.7 95% CI 1.2, 2.3), smokers (PR = 1.5 95% CI 1.2, 1.9) and those who reported alcohol problems (PR = 1.4 95% CI 1.1; 1.9). To be 40 years of age (PR = 0.5 95% CI 0.4, 0.7) and use dental service in the last year (RR = 0.5 95% CI 0.4, 0.6) were protective factors for toothache.

Conclusion
The prevalence of toothache in adults of Lages can be considered a major problem of dental public health.
Comparison of bee products based on assays of antioxidant capacities
Authors: Nakajima Yoshimi , Tsuruma Kazuhiro , Shimazawa Masamitsu , Mishima Satoshi , Hara Hideaki 
Published: February 2009

Abstract

Background
Bee products (including propolis, royal jelly, and bee pollen) are popular, traditional health foods. We compared antioxidant effects among water and ethanol extracts of Brazilian green propolis (WEP or EEP), its main constituents, water-soluble royal jelly (RJ), and an ethanol extract of bee pollen.

Methods
The hydrogen peroxide (H2O2)-, superoxide anion (O2
·-)-, and hydroxyl radical (HO·)- scavenging capacities of bee products were measured using antioxidant capacity assays that employed the reactive oxygen species (ROS)-sensitive probe 5-(and-6)-chloromethyl-2',7'-dichlorodihydrofluorescein diacetate, acetyl ester (CM-H2DCFDA) or aminophenyl fluorescein (APF).

Results
The rank order of antioxidant potencies was as follows: WEP > EEP > pollen, but neither RJ nor 10-hydroxy-2-decenoic acid (10-HDA) had any effects. Concerning the main constituents of WEP, the rank order of antioxidant effects was: caffeic acid > artepillin C > drupanin, but neither baccharin nor coumaric acid had any effects. The scavenging effects of caffeic acid were as powerful as those of trolox, but stronger than those of N-acetyl cysteine (NAC) or vitamin C.

Conclusion
On the basis of the present assays, propolis is the most powerful antioxidant of all the bee product examined, and its effect may be partly due to the various caffeic acids it contains. Pollen, too, exhibited strong antioxidant effects.
The origins of phagocytosis and eukaryogenesis
Authors: Yutin Natalya , Wolf Maxim Y , Wolf Yuri I , Koonin Eugene V 
Published: February 2009

Abstract

Background
Phagocytosis, that is, engulfment of large particles by eukaryotic cells, is found in diverse organisms and is often thought to be central to the very origin of the eukaryotic cell, in particular, for the acquisition of bacterial endosymbionts including the ancestor of the mitochondrion.

Results
Comparisons of the sets of proteins implicated in phagocytosis in different eukaryotes reveal extreme diversity, with very few highly conserved components that typically do not possess readily identifiable prokaryotic homologs. Nevertheless, phylogenetic analysis of those proteins for which such homologs do exist yields clues to the possible origin of phagocytosis. The central finding is that a subset of archaea encode actins that are not only monophyletic with eukaryotic actins but also share unique structural features with actin-related proteins (Arp) 2 and 3. All phagocytic processes are strictly dependent on remodeling of the actin cytoskeleton and the formation of branched filaments for which Arp2/3 are responsible. The presence of common structural features in Arp2/3 and the archaeal actins suggests that the common ancestors of the archaeal and eukaryotic actins were capable of forming branched filaments, like modern Arp2/3. The Rho family GTPases that are ubiquitous regulators of phagocytosis in eukaryotes appear to be of bacterial origin, so assuming that the host of the mitochondrial endosymbiont was an archaeon, the genes for these GTPases come via horizontal gene transfer from the endosymbiont or in an earlier event.

Conclusion
The present findings suggest a hypothetical scenario of eukaryogenesis under which the archaeal ancestor of eukaryotes had no cell wall (like modern Thermoplasma) but had an actin-based cytoskeleton including branched actin filaments that allowed this organism to produce actin-supported membrane protrusions. These protrusions would facilitate accidental, occasional engulfment of bacteria, one of which eventually became the mitochondrion. The acquisition of the endosymbiont triggered eukaryogenesis, in particular, the emergence of the endomembrane system that eventually led to the evolution of modern-type phagocytosis, independently in several eukaryotic lineages.

Reviewers
This article was reviewed by Simonetta Gribaldo, Gaspar Jekely, and Pierre Pontarotti. For the full reviews, please go to the Reviewers' Reports section.
Mechanical characteristics of three staples commonly used in foot surgery
Authors: Rethnam Ulfin , Kuiper Jan , Makwana Nilesh 
Published: February 2009

AbstractBackgroundBone staples are an accepted method of fixation in foot surgery. They reduce operating time and trauma in surgical procedures. A variety of memory staples are available but their properties compared to standard staples are not known. We carried out a study comparing two popular types of memory staples and a standard stainless steel staple.MethodsStandardized bone models of metatarsals made from Tufnol tubes were osteotomized and stabilised using one of three types of bone staples, two types of memory staple (Memory staple and heat‐activated Memoclip) or a standard stainless steel staple (Richards). Constructs were loaded in bending and torsion on a material testing machine. The moment and torque to achieve 10 degree of bending or torsion and permanent angulation of the osteotomized bones were assessed.ResultsThe Richards staple was found to provide a four times larger resistance to bending and torsion than the two memory staples. However, it was permanently deformed after bending. The Memory and Memoclip staples were equal in their stiffness. In addition, angulation of bones fixed with the Memoclip was elastic, preventing any permanent deformation.ConclusionThe Richards staple was stiffer, although the permanent deformation of this staple is a disadvantage. Memoclip staples exhibit lower but adequate stiffnesss when compared to the standard Richards staple and are not permanently deformed after bending. The Memoclip staples were easier to handle. The results will enable surgeons to determine the optimal staple for foot and ankle procedures.
Utilizing the Molecular Gateway: The Path to Personalized Cancer Management
Authors: Overdevest Jonathan B , Theodorescu Dan , Lee Jae K 
Published: February 2009

Abstract
Background: Personalized medicine is the provision of focused prevention, detection, prognostic, and therapeutic efforts according to an individual’s genetic composition. The actualization of personalized medicine will require combining a patient’s conventional clinical data with bioinformatics-based molecular-assessment profiles. This synergistic approach offers tangible benefits, such as heightened specificity in the molecular classification of cancer subtypes, improved prognostic accuracy, targeted development of new therapies, novel applications for old therapies, and tailored selection and delivery of chemotherapeutics.
Content: Our ability to personalize cancer management is rapidly expanding through biotechnological advances in the postgenomic era. The platforms of genomics, proteomics, single-nucleotide polymorphism profiling and haplotype mapping, high-throughput genomic sequencing, and pharmacogenomics constitute the mechanisms for the molecular assessment of a patient’s tumor. The complementary data derived during these assessments is processed through bioinformatics analysis to offer unique insights for linking expression profiles to disease detection, tumor response to chemotherapy, and patient survival. Together, these approaches permit improved physician capacity to assess risk, target therapies, and tailor a chemotherapeutic treatment course.
Summary: Personalized medicine is poised for rapid growth as the insights provided by new bioinformatics models are integrated with current procedures for assessing and treating cancer patients. Integration of these biological platforms will require refinement of tissue-processing and analysis techniques, particularly in clinical pathology, to overcome obstacles in customizing our ability to treat cancer.
Shear Deformation of Locked Sand in Triaxial Compression
Authors: Wong RCK 
Published: February 2009

Abstract
Dense, uncemented, locked Athabasca oil sand specimens were tested in drained triaxial compression with enlarged lubricated platen ends. Computer tomography and scanning electron microscopy (SEM) imaging techniques were used to examine the micro-structural features of the intact and sheared specimens. The micro-structures studied in this paper include shear banding pattern, shear band thickness, and spatial porosity distributions inside and outside shear bands.
An Electrokinetic Testing Apparatus for Undisturbed/Remoulded Soils under In-Situ Stress Conditions
Authors: Shang JQ , Masterson KL 
Published: February 2009

Abstract
In this paper, the design and construction of an apparatus for the study of electrokinetics are presented in detail. The apparatus is capable of both applying a designated effective stress to a soil sample and measuring the volume change and pore pressure during the electrokinetic testing. The results of a high voltage electrokinetic test on a remolded natural clay sample are reported to illustrate the operation of the apparatus and to study the mechanism of high voltage electrokinetics. During the 91 day test period of, including the application of a high voltage (−10 kV to −12 kV) for 51 days via insulated electrodes, the volume and pore pressure changes were negligible. Nevertheless, the geotechnical properties of the soil significantly improved, including increases in shear strength (69%), shear modulus (151%) and preconsolidation pressure (700%). Since the increases are calculated with respect to the control sample under identical effective stress and drainage conditions over the same time period, they can only be attributed to high voltage electrokinetic effects, possibly cementation bonding, diagenesis, and ionic diffusion.
The electrokinetic testing apparatus developed in this study provides a viable tool for the study of electrokinetics on clayey soils for better understanding of the mechanisms involved in the process.
Elastic Modulus of Geogrid-Reinforced Sand Using Plate Load Tests
Authors: Gabr MA , Hart JH 
Published: February 2009

Abstract
An experimental study was conducted to evaluate the elastic modulus of sand reinforced with polymeric geogrids. A total of nine plate load tests were performed in the laboratory using a 1.52 m × 1.52 m × 1.37 m (length × width × depth) test box, and a 0.3 m square test plate. The measured test data were used to evaluate a modulus constant (E1), rather than the bearing capacity, as traditionally presented in literature. The modulus constant was estimated based on two deformation levels of 9.2 mm and 4.6 mm. These deformation levels, defined as δ1 and δ0.5, correspond to normalized settlement ratios (δ/B) of 1.5 and 3.0%, respectively, where B = width of the test plate. In general, a stiffer load-settlement response was measured when the geogrid reinforcement was included. Using SR1 geogrids with sand, the modulus constant (E1) decreased as a function of increasing u/B ratio (u = distance from plate to Eop reinforcement layer). In comparison, results indicated the presence of a critical u/B ratio when the SR2 geogrids were used. In this study, this particular ratio was estimated to be 0.65. Values of E1 from large scale model testing by Adams and Collin (1997) correlated well with E1 values evaluated from this testing program.