bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combining multi-mode thermal therapy with IL-6 and IL-17A neutralization amplifies antitumor immunity to facilitate long-term survival in LLC1-bearing mice
Authors: Zheng Jiamin , Zou Jincheng , Lou Yue , Wang Shicheng , Zhang Zelu , Wang Junjun , Du Peishan , Zhu Yongxin , You Jiaqi , Yao Yichen , Hao Yuankai , Zhang Aili , Liu Ping 
Published: April 2024

AbstractNon-small cell lung cancer (NSCLC) is known for rapid development and chronic inflammation-induced immunosuppression. IL-6 and IL-17A are the essential cytokines that facilitate NSCLC progression and myeloid-derived suppressive cell (MDSC)-mediated evasion. IL-6 or IL-17A targeting, especially IL-6, shown outstanding efficacy in patient NSCLC controlling, but failed to completely eradicate tumor. The local tumor multi-mode thermal therapy developed in our prior research was demonstrated to stimulate systemic and durable tumor-specific immune response thereby promoting long-term tumor-free survival of mice and prolong the progression-free survival of patients, although the therapeutic efficacy was still affected by high-level preoperative MDSCs. To further improve the efficacy, in this study, IL-6 and IL-17A neutralization were combined with multi-mode thermal therapy in mouse LLC1 NSCLC model. Study revealed that combined with single cytokine neutralization only prolonged the survival time while triple combination therapy efficiently improved the survival rate. Additionally, triple combination therapy reduced the accumulation of MDSCs but promoted their maturation with strengthened activation and function of myeloid cells, thereby triggering a Th1-dominant-CD4+ T cell-response and enhancing the malignant cell-killing capacity of immune cells. Our study highlights the extraordinary efficacy of combining multi-mode thermal therapy with IL-6 and IL-17A neutralization, revealing a new strategy for refractory NSCLC patients.
Graphical Abstract
NONDEFINABILITY RESULTS FOR ELLIPTIC AND MODULAR FUNCTIONS
Authors: MCCULLOCH RAYMOND 
Published: April 2024

Abstract
Let

$\Omega $

be a complex lattice which does not have complex multiplication and

$\wp =\wp _\Omega $

the Weierstrass

$\wp $

-function associated with it. Let

$D\subseteq \mathbb {C}$

be a disc and

$I\subseteq \mathbb {R}$

be a bounded closed interval such that

$I\cap \Omega =\varnothing $

. Let

$f:D\rightarrow \mathbb {C}$

be a function definable in

$(\overline {\mathbb {R}},\wp |_I)$

. We show that if f is holomorphic on D then f is definable in

$\overline {\mathbb {R}}$

. The proof of this result is an adaptation of the proof of Bianconi for the

$\mathbb {R}_{\exp }$

case. We also give a characterization of lattices with complex multiplication in terms of definability and a nondefinability result for the modular j-function using similar methods.
HERMESIANAX'S POETICS OF LOVE IN CONTEXT
Authors: Giuseppetti Massimo 
Published: April 2024

AbstractThe article focusses on the catalogue of love-affairs from Book 3 of Hermesianax's Leontion (fr. 7 Powell = 3 Lightfoot). Contrary to two basic assumptions of previous scholarship, this article underscores that fr. 3 Lightfoot is neither representative of the Leontion as a whole nor an instance of unsophisticated poetic production. The evidence indicates that Hermesianax's catalogue might have played a crucial role in shaping the later reception of some of the figures he portrays (Mimnermus, Antimachus and perhaps even Hesiod). Finally, several points of contact with Clearchus of Soli show that Hermesianax may be engaging with relevant aspects of contemporary culture, most of all the Peripatetic investigation of biography and the phenomenology of love.
Ethical and Equitable Digital Health Research: Ensuring Self-Determination in Data Governance for Racialized Communities
Authors: Islam Mozharul , Valiani Arafaat A. , Datta Ranjan , Chowdhury Mohammad , Turin Tanvir C. 
Published: April 2024

Abstract
Recent studies highlight the need for ethical and equitable digital health research that protects the rights and interests of racialized communities. We argue for practices in digital health that promote data self-determination for these communities, especially in data collection and management. We suggest that researchers partner with racialized communities to curate data that reflects their wellness understandings and health priorities, and respects their consent over data use for policy and other outcomes. These data governance approach honors and builds on Indigenous Data Sovereignty (IDS) decolonial scholarship by Indigenous and non-indigenous researchers and its adaptations to health research involving racialized communities from former European colonies in the global South. We discuss strategies to practice equity, diversity, inclusion, accessibility and decolonization (EDIAD) principles in digital health. We draw upon and adapt the concept of Precision Health Equity (PHE) to emphasize models of data sharing that are co-defined by racialized communities and researchers, and stress their shared governance and stewardship of data that is generated from digital health research. This paper contributes to an emerging research on equity issues in digital health and reducing health, institutional, and technological disparities. It also promotes the self-determination of racialized peoples through ethical data management.
Atrioventricular valve surgery in patients with univentricular heart and two separate atrioventricular valves
Authors: Mayr Benedikt , Osawa Takuya , Staehler Helena , Schaeffer Thibault , Röhlig Christoph , Cleuziou Julie , Hager Alfred , Ewert Peter , Hörer Jürgen , Lange Rüdiger , Ono Masamichi 
Published: April 2024

AbstractObjectives:Atrioventricular valve regurgitation in patients with univentricular heart is a well-known risk factor for adverse outcomes and atrioventricular valve repair remains a particular surgical challenge.Methods:We reviewed all surgical atrioventricular valve procedures in patients with univentricular heart and two separate atrioventricular valves who underwent surgical palliation. Endpoints of the study were reoperation-free survival and cumulative incidence of reoperation.Results:Between 1994 and 2021, 202 patients with univentricular heart and two separate atrioventricular valve morphology underwent surgical palliation, with 15.8% (32/202) requiring atrioventricular valve surgery. Primary diagnoses were double inlet left ventricle (n = 14, 43.8%), double outlet right ventricle (n = 7, 21.9%), and congenitally corrected transposition of the great arteries (n = 7, 21.9%). Median weight at valve surgery was 10.6 kg (interquartile range, 7.9–18.9). Isolated left or right atrioventricular valve surgery was required in nine (28.1%) and 22 patients (68.8%), respectively. Concomitant left and right atrioventricular valve surgery was performed in one patient (3.1%). Closure of the left valve was conducted in four patients (12.5%) and closure of the right valve in three (9.4%). Operative and late mortality were 3.1% and 9.7%, respectively. Reoperation-free survival and cumulative incidence of reoperation at 10 years after surgery were 62.3% (standard error of the mean: 6.9) and 30.9% (standard error of the mean: 9.6), respectively.Conclusions:In patients with univentricular heart and two separate atrioventricular valves, surgical intervention on these valves is required in a minority of patients and is associated with low mortality but high incidence of reoperation.
Tracking the Subsolar Bow Shock and Magnetopause: Applying the Magnetosheath Velocity Gradient Method
Authors: Silveira M. V. D. , Sibeck D. G. , Cardoso F. R. , Gjerloev J. W. 
Published: April 2024

AbstractBoth the bow shock and magnetopause move in response to varying solar wind and magnetospheric conditions. Tracking their locations can provide important clues to the state of the solar wind‐magnetosphere interaction, but is difficult with single spacecraft observations. This paper employs multipoint THEMIS observations of velocity gradients in the subsolar magnetosheath to remotely sense boundary locations on a continual basis for various solar wind conditions. We present three cases: (a) continuous northward IMF and no magnetopause motion; (b) southward IMF and no magnetopause motion with evidence of nightside activity; and (c) southward IMF and pressure increase with inward motion. When observing spacecraft are located near the Sun‐Earth line, inferred boundary locations agree well with the predictions of the BATS‐R‐US global magnetohydrodynamic model, confirming the utility of both the new method and the models. Results show that boundaries often lie nearly at rest with amplitudes less than 0.5 RE. They provide evidence indicating that nightside reconnection and a strong sunward convection in the outer magnetosphere can counteract the magnetopause erosion expected when a southward interplanetary magnetic field (IMF) initiates reconnection on the dayside magnetopause.
Does a Scale‐Aware Convective Parameterization Scheme Improve the Simulation of Heavy Rainfall Events?
Authors: Park Haerin , Hwang Jiwon , Cha Dong‐Hyun , Lee Myong‐In , Song Chang‐Keun , Kim Joowan , Park Sang‐Hun , Lee Dong‐Kyou 
Published: April 2024

AbstractPrecipitation predictability using the non‐scale‐aware and scale‐aware convective parameterization schemes (CPSs) was investigated to assess the necessity of the CPSs within the gray‐zone. This study evaluates the performance of the Weather Research and Forecasting (WRF) model's CPS for 135 heavy rainfall events (HREs) over the Korean Peninsula for 10 years (i.e., 2011–2020). We tested the Kain–Fritsch (KF) scheme (non‐scale‐aware) and Multi‐scale Kain–Fritsch (MSKF) scheme (scale‐aware) in the WRF model. The MSKF scheme shows an overall improved performance of precipitation simulation compared to the KF scheme, but the precipitation forecast performance of CPS depends on the characteristics of HREs. When the HREs are characterized by synoptic‐scale atmospheric conditions with strong winds and large‐scale water vapor transport, the forecast performance of both CPSs is similar because a cloud microphysics scheme can explicitly resolve most of the precipitation. However, in the case of HREs with weak synoptic forcing conditions (e.g., moisture transport and winds) related to the localized and meso‐scale HREs, the MSKF scheme can improve overall simulated precipitation by increasing grid‐scale precipitation and reducing the overestimation of subgrid‐scale precipitation simulated in the KF scheme. Therefore, using the scale‐aware CPS in the gray‐zone can provide more accurate precipitation forecasts regardless of the environmental condition of the HREs.
Where in the World Are Vegetation Patterns Controlled by Hillslope Water Dynamics?
Authors: Li Shuping , Yamazaki Dai , Zhou Xudong , Zhao Gang 
Published: April 2024

AbstractSome recent land surface models can explicitly represent land surface process and focus more on sub‐grid terrestrial features. Many studies have involved the analysis of how hillslope water dynamics determine vegetation patterns and shape ecologically and hydrologically important landscapes, such as desert riparian and waterlogged areas. However, the global locations and abundance of hillslope‐dominated landscapes remain unclear. To address this knowledge gap, we propose a globally applicable method that employs high‐resolution elevation, hydrography, and land cover data to concisely resolve explicit land cover heterogeneity for the mapping of hillslope‐dominated landscapes. First, we aggregate pixels into unit catchments to represent topography‐based hydrological units, and then vertically discretize them into height bands to approximate the hillslope profile. The dominant land cover type in each height band is determined, and the uphill land cover transition is analyzed to identify hillslope‐dominated landscapes. The results indicate that hillslope‐dominated landscapes are distributed extensively worldwide in diverse climate zones. Notably, some landscapes, including gallery forests in northeastern Russia and desert riparian in the Horn of Africa, are newly revealed. Furthermore, the proposed strategy enables more accurate representation of explicit land cover heterogeneity than does the simple downscaling of a rectangular grid from larger to smaller units, revealing its capability to concisely resolve land cover heterogeneity in land surface modeling with relatively high accuracy. Overall, we present the extensive global distribution of landscapes shaped by hillslope water dynamics, underscoring the importance of the explicit resolution of heterogeneity in land surface modeling.
Spatiotemporal Variation of the Cretaceous‐Eocene Arc Magmatism in Lhasa‐Tengchong Terrane
Authors: Liu Yongmin , Fan Weiming , Peng Touping , Shi Rendeng , Chen Shengsheng , Huangfu Pengpeng 
Published: April 2024

AbstractIt was recognized that two magmatic belts in the Lhasa‐Tengchong terrane formed due to the Mesozoic‐Cenozoic Tethyan evolution. Still, their spatiotemporal variations of magmatic flare‐ups/lulls are rarely discussed. Here we use the new U‐Pb and Lu‐Hf isotopic data of captured zircons and a comprehensive data set to show that the flare‐up of northern magmatic belt has peak ages of 110 Ma in central and northern Lhasa and 120 Ma in eastern Tengchong, possibly related to the tectonic transition from Meso‐ and Neo‐Tethyan double subduction to Neo‐Tethyan single subduction. For the southern magmatic belt, the flare‐ups at 100–85 Ma and 65–45 Ma in eastern southern Lhasa indicate obvious juvenile crustal growth, while flare‐ups at 75–45 Ma in western southern Lhasa and Tengchong record ancient crustal reworking. Such flare‐up variations in the southern magmatic belt possibly resulted from asynchronous changes in the Neo‐Tethyan slab dip.
Using the benefit-harm trade-off method to determine the smallest worthwhile effect of intensive motor training on strength for people with spinal cord injury
Authors: Tranter Keira E. , Glinsky Joanne V. , Ben Marsha , Patterson Helen , Blecher Lynn , Chu Jackie , Harvey Lisa A. 
Published: April 2024

Abstract
Study design
Interviews using the benefit-harm trade-off method and an online survey.

Objectives
To determine the smallest worthwhile effect (SWE) of motor training on strength for people with spinal cord injury (SCI).

Setting
SCI units, Australia.

Methods
Forty people with recent SCI who had participated in motor training as part of their rehabilitation program (patient participants) and 37 physiotherapists (physiotherapist participants) working in SCI were recruited. The patient participants underwent an iterative process using the benefit-harm trade-off method to determine the SWE of motor training on strength. The physiotherapist participants were given an online survey to determine the SWE for five different scenarios. Both groups considered the SWE of a physiotherapy intervention involving an additional 12 h of motor training for 10 weeks on top of usual care. They were required to estimate the smallest improvement in strength (points on the Total Motor Score of the International Standards for Neurological Classification of SCI) to justify the effort and associated costs, risks or inconveniences of the motor training.

Results
The median (interquartile range) smallest improvement in strength that patient and physiotherapist participants deemed worth the effort and associated costs, risks or inconveniences of the motor training was 3 (1–5) points, and 9 (7–13) points, respectively.

Conclusions
People with recent SCI are willing to devote 12 h a week for 10 weeks to motor training in addition to their usual care to gain small changes in strength. Physiotherapists wanted to see greater improvements to justify the intervention.
Behaviour-correlated profiles of cerebellar-cerebral functional connectivity observed in independent neurodevelopmental disorder cohorts
Authors: Morgado Felipe , Vandewouw Marlee M. , Hammill Christopher , Kelley Elizabeth , Crosbie Jennifer , Schachar Russell , Ayub Muhammad , Nicolson Robert , Georgiades Stelios , Arnold Paul , Iaboni Alana , Kushki Azadeh , Taylor Margot J. , Anagnostou Evdokia , Lerch Jason P. 
Published: April 2024

AbstractThe cerebellum, through its connectivity with the cerebral cortex, plays an integral role in regulating cognitive and affective processes, and its dysregulation can result in neurodevelopmental disorder (NDD)-related behavioural deficits. Identifying cerebellar-cerebral functional connectivity (FC) profiles in children with NDDs can provide insight into common connectivity profiles and their correlation to NDD-related behaviours. 479 participants from the Province of Ontario Neurodevelopmental Disorders (POND) network (typically developing = 93, Autism Spectrum Disorder = 172, Attention Deficit/Hyperactivity Disorder = 161, Obsessive-Compulsive Disorder = 53, mean age = 12.2) underwent resting-state functional magnetic resonance imaging and behaviour testing (Social Communication Questionnaire, Toronto Obsessive-Compulsive Scale, and Child Behaviour Checklist – Attentional Problems Subscale). FC components maximally correlated to behaviour were identified using canonical correlation analysis. Results were then validated by repeating the investigation in 556 participants from an independent NDD cohort provided from a separate consortium (Healthy Brain Network (HBN)). Replication of canonical components was quantified by correlating the feature vectors between the two cohorts. The two cerebellar-cerebral FC components that replicated to the greatest extent were correlated to, respectively, obsessive-compulsive behaviour (behaviour feature vectors, rPOND-HBN = −0.97; FC feature vectors, rPOND-HBN = −0.68) and social communication deficit contrasted against attention deficit behaviour (behaviour feature vectors, rPOND-HBN = −0.99; FC feature vectors, rPOND-HBN = −0.78). The statistically stable (|z| > 1.96) features of the FC feature vectors, measured via bootstrap re-sampling, predominantly comprised of correlations between cerebellar attentional and control network regions and cerebral attentional, default mode, and control network regions. In both cohorts, spectral clustering on FC loading values resulted in subject clusters mixed across diagnostic categories, but no cluster was significantly enriched for any given diagnosis as measured via chi-squared test (p > 0.05). Overall, two behaviour-correlated components of cerebellar-cerebral functional connectivity were observed in two independent cohorts. This suggests the existence of generalizable cerebellar network differences that span across NDD diagnostic boundaries.
Heat flows enrich prebiotic building blocks and enhance their reactivity
Authors: Matreux Thomas , Aikkila Paula , Scheu Bettina , Braun Dieter , Mast Christof B. 
Published: April 2024

AbstractThe emergence of biopolymer building blocks is a crucial step during the origins of life1–6. However, all known formation pathways rely on rare pure feedstocks and demand successive purification and mixing steps to suppress unwanted side reactions and enable high product yields. Here we show that heat flows through thin, crack-like geo-compartments could have provided a widely available yet selective mechanism that separates more than 50 prebiotically relevant building blocks from complex mixtures of amino acids, nucleobases, nucleotides, polyphosphates and 2-aminoazoles. Using measured thermophoretic properties7,8, we numerically model and experimentally prove the advantageous effect of geological networks of interconnected cracks9,10 that purify the previously mixed compounds, boosting their concentration ratios by up to three orders of magnitude. The importance for prebiotic chemistry is shown by the dimerization of glycine11,12, in which the selective purification of trimetaphosphate (TMP)13,14 increased reaction yields by five orders of magnitude. The observed effect is robust under various crack sizes, pH values, solvents and temperatures. Our results demonstrate how geologically driven non-equilibria could have explored highly parallelized reaction conditions to foster prebiotic chemistry.
Molecular insights into capsular polysaccharide secretion
Authors: Kuklewicz Jeremi , Zimmer Jochen 
Published: April 2024

AbstractCapsular polysaccharides (CPSs) fortify the cell boundaries of many commensal and pathogenic bacteria1. Through the ABC-transporter-dependent biosynthesis pathway, CPSs are synthesized intracellularly on a lipid anchor and secreted across the cell envelope by the KpsMT ABC transporter associated with the KpsE and KpsD subunits1,2. Here we use structural and functional studies to uncover crucial steps of CPS secretion in Gram-negative bacteria. We show that KpsMT has broad substrate specificity and is sufficient for the translocation of CPSs across the inner bacterial membrane, and we determine the cell surface organization and localization of CPSs using super-resolution fluorescence microscopy. Cryo-electron microscopy analyses of the KpsMT–KpsE complex in six different states reveal a KpsE-encaged ABC transporter, rigid-body conformational rearrangements of KpsMT during ATP hydrolysis and recognition of a glycolipid inside a membrane-exposed electropositive canyon. In vivo CPS secretion assays underscore the functional importance of canyon-lining basic residues. Combined, our analyses suggest a molecular model of CPS secretion by ABC transporters.
Immune microniches shape intestinal Treg function
Authors: Gu Yisu , Bartolomé-Casado Raquel , Xu Chuan , Bertocchi Alice , Janney Alina , Heuberger Cornelia , Pearson Claire F. , Teichmann Sarah A. , Thornton Emily E. , Powrie Fiona 
Published: April 2024

AbstractThe intestinal immune system is highly adapted to maintaining tolerance to the commensal microbiota and self-antigens while defending against invading pathogens1,2. Recognizing how the diverse network of local cells establish homeostasis and maintains it in the complex immune environment of the gut is critical to understanding how tolerance can be re-established following dysfunction, such as in inflammatory disorders. Although cell and molecular interactions that control T regulatory (Treg) cell development and function have been identified3,4, less is known about the cellular neighbourhoods and spatial compartmentalization that shapes microorganism-reactive Treg cell function. Here we used in vivo live imaging, photo-activation-guided single-cell RNA sequencing5–7 and spatial transcriptomics to follow the natural history of T cells that are reactive towards Helicobacter hepaticus through space and time in the settings of tolerance and inflammation. Although antigen stimulation can occur anywhere in the tissue, the lamina propria—but not embedded lymphoid aggregates—is the key microniche that supports effector Treg (eTreg) cell function. eTreg cells are stable once their niche is established; however, unleashing inflammation breaks down compartmentalization, leading to dominance of CD103+SIRPα+ dendritic cells in the lamina propria. We identify and validate the putative tolerogenic interaction between CD206+ macrophages and eTreg cells in the lamina propria and identify receptor–ligand pairs that are likely to govern the interaction. Our results reveal a spatial mechanism of tolerance in the lamina propria and demonstrate how knowledge of local interactions may contribute to the next generation of tolerance-inducing therapies.