bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cytomegalovirus Colitis in a Patient with Severe Treatment Refractory Ulcerative Colitis
Authors: Bao Michelle M , Kennedy Juliana M , Dolinger Michael T , Dunkin David , Lai Joanne , Dubinsky Marla C 
Published: February 2024

Abstract

Background
Cytomegalovirus (CMV) can be reactivated in ulcerative colitis (UC), but its role in progression of inflammation is unclear. Risk factors include severe colitis and treatment with immunosuppressive medications, particularly corticosteroids and immunomodulators.

Methods
We report a case of cytomegalovirus colitis in a pediatric patient with pancolitis who had been refractory to aminosalicylate, infliximab, and ustekinumab and was in clinical remission and with transmural response on upadacitinib.

Results
This is a case of a 13-year-old male with UC refractory to multiple therapies who were in clinical remission on upadacitinib 30 mg daily. He developed an acute increase in symptoms and did not respond to therapy escalation with increased upadacitinib 45 mg daily for 2 weeks and prednisone for 1 week. He was diagnosed with cytomegalovirus colitis on flexible sigmoidoscopy biopsy. He was treated with intravenous ganciclovir with tapering of immunosuppressive regimen. Despite initial response, he underwent subtotal colectomy and subsequent restorative proctocolectomy with ileal pouch anal-anastomosis.

Conclusions
Despite our patient having multiple risk factors for developing CMV colitis, upadacitinib may have played a role when considering its known impact on the herpes family of viruses. CMV colitis should be evaluated for in any patient who presents with worsening symptoms without evidence of other infection or response to increase in therapy.
Compensation or accentuation? How parents from different social backgrounds decide to support their children
Authors: Dierker Philipp , Diewald Martin 
Published: February 2024

Abstract
Previous research has shown that parents respond to differences in their children’s potential by providing them with different levels of support, and that such support allocation decisions are shaped by socioeconomic status (SES). We extend this observation to the assumption, raised in research on parental compensation and social mobility, that not only the allocation, but also the form of support provided is socially stratified. Specifically, we investigate whether socioeconomically advantaged parents use mechanisms that do not rely directly on cognitive enhancement. Drawing on data from three consecutive waves of the German TwinLife study (N = 960), we use twin fixed-effects models to examine how parents respond to their children having different grades. We investigate parental support strategies, including help with schoolwork and school-related communication, encouragement and explicitly formulated expectations, and extracurricular cognitive stimulation. Our findings suggest that high-SES parents tend to compensate for their children’s poor performance by helping them with schoolwork, fostering communication, and formulating academic expectations and encouragement. However, no significant differences in support allocation between high- and low-SES parents were found. Moreover, we found no evidence that parents in either high- or low-SES families respond to differences in their children’s school performance by providing them with extracurricular cognitive stimulation.
Pulmonary arterial hypertension treatment: an individual participant data network meta-analysis
Authors: Moutchia Jude , McClelland Robyn L , Al-Naamani Nadine , Appleby Dina H , Holmes John H , Minhas Jasleen , Mazurek Jeremy A , Palevsky Harold I , Ventetuolo Corey E , Kawut Steven M 
Published: February 2024

Abstract

Background and Aims
Effective therapies that target three main signalling pathways are approved to treat pulmonary arterial hypertension (PAH). However, there are few large patient-level studies that compare the effectiveness of these pathways. The aim of this analysis was to compare the effectiveness of the treatment pathways in PAH and to assess treatment heterogeneity.

Methods
A network meta-analysis was performed using individual participant data of 6811 PAH patients from 20 Phase III randomized clinical trials of therapy for PAH that were submitted to the US Food and Drug Administration. Individual drugs were grouped by the following treatment pathways: endothelin, nitric oxide, and prostacyclin pathways.

Results
The mean (±standard deviation) age of the sample was 49.2 (±15.4) years; 78.4% were female, 59.7% had idiopathic PAH, and 36.5% were on background PAH therapy. After covariate adjustment, targeting the endothelin + nitric oxide pathway {β: 43.7 m [95% confidence interval (CI): 32.9, 54.4]}, nitric oxide pathway [β: 29.4 m (95% CI: 22.6, 36.3)], endothelin pathway [β: 25.3 m (95% CI: 19.8, 30.8)], and prostacyclin pathway [oral/inhaled β: 19.1 m (95% CI: 14.2, 24.0), intravenous/subcutaneous β: 24.4 m (95% CI: 15.1, 33.7)] significantly increased 6 min walk distance at 12 or 16 weeks compared with placebo. Treatments also significantly reduced the likelihood of having clinical worsening events. There was significant heterogeneity of treatment effects by age, body mass index, hypertension, diabetes, and coronary artery disease.

Conclusions
Drugs targeting the three traditional treatment pathways significantly improve outcomes in PAH, with significant treatment heterogeneity in patients with some comorbidities. Randomized clinical trials are warranted to identify the most effective treatment strategies in a personalized approach.
Catheter ablation of ventricular tachycardia in patients with arrhythmogenic right ventricular cardiomyopathy and biventricular involvement
Authors: Shen Lishui , Liu Shangyu , Zhang Zhenhao , Xiong Yulong , Lai Zihao , Hu Feng , Zheng Lihui , Yao Yan 
Published: February 2024

Abstract

Aims
Catheter ablation of ventricular tachycardia (VT) improves VT-free survival in ‘classic’ arrhythmogenic right ventricular cardiomyopathy (ARVC). This study aims to investigate electrophysiological features and ablation outcomes in patients with ARVC and biventricular (BiV) involvement.

Methods and results
We assembled a retrospective cohort of definite ARVC cases with sustained VTs. Patients were divided into the BiV (BiV involvement) group and the right ventricular (RV) (isolated RV involvement) group based on the left ventricular systolic function detected by cardiac magnetic resonance. All patients underwent electrophysiological mapping and VT ablation. Acute complete success was non-inducibility of any sustained VT, and the primary endpoint was VT recurrence. Ninety-eight patients (36 ± 14 years; 87% male) were enrolled, including 50 in the BiV group and 48 in the RV group. Biventricular involvement was associated with faster clinical VTs, a higher VT inducibility, and more extensive arrhythmogenic substrates (all P &lt; 0.05). Left-sided VTs were observed in 20% of the BiV group cases and correlated with significantly reduced left ventricular systolic function. Catheter ablation achieved similar acute efficacy between these two groups, whereas the presence of left-sided VTs increased acute ablation failure (40 vs. 5%, P = 0.012). Over 51 ± 34 months [median, 48 (22–83) months] of follow-up, cumulative VT-free survival was 52% in the BiV group and 58% in the RV group (P = 0.353). A multivariate analysis showed that younger age, lower RV ejection fraction (RVEF), and non-acute complete ablation success were associated with VT recurrence in the BiV group.

Conclusion
Biventricular involvement implied a worse arrhythmic phenotype and increased the risk of left-sided VTs, while catheter ablation maintained its efficacy for VT control in this population. Younger age, lower RVEF, and non-acute complete success predicted VT recurrence after ablation.
Recognizing bisphosphonate-induced ear osteonecrosis in primary care: a case report
Authors: Mayer Alasdair W , Oladokun Dare , Mistry Dipan 
Published: February 2024

Abstract

Introduction
Medication-related ear canal osteonecrosis (MRECO) is a growing concern linked to prolonged anti-resorptive medication use. Despite primary care providers being key prescribers of these medications, there is limited information about MRECO in primary care literature. This article presents a case of bisphosphonate-induced osteonecrosis of the external auditory canal (EAC), emphasizing the vital role of primary care providers in identifying this rare yet significant side effect of anti-resorptive medication.

Main symptoms and clinical findings
A 65-year-old female, on long-term alendronic acid for osteoporosis, presented to primary care with a 2-year history of left-sided ear blockage and itchiness. Despite prolonged topical treatment for ear wax, symptoms persisted, leading to an Otolaryngology referral. Microsuction revealed exposed bone in the left EAC.

Diagnoses, interventions, and outcomes
A computed tomography scan confirmed bony erosion of the left EAC, and in the absence of other osteonecrosis risk factors, bisphosphonate-induced osteonecrosis was diagnosed. Management involved bisphosphonate discontinuation, regular aural toilet, and topical treatment, achieving complete ear canal epithelialisation within 6 months.

Conclusion
MRECO, a rare complication of anti-resorptive therapy, is anticipated to rise with increasing antiresorptive medication use in the ageing population. Unexplained ear symptoms in those with a history of current or prior anti-resorptive therapy should raise clinical concern, prompting evaluation for exposed bone in the EAC. Raising awareness of MRECO among primary care providers is crucial for early diagnosis and timely management.
Age Is Associated With Dampened Circadian Patterns of Rest and Activity: The Study of Muscle, Mobility, and Aging (SOMMA)
Authors: Erickson Melissa L , Blackwell Terri L , Mau Theresa , Cawthon Peggy M , Glynn Nancy W , Qiao Yujia (Susanna) , Cummings Steven R , Coen Paul M , Lane Nancy E , Kritchevsky Stephen B , Newman Anne B , Farsijani Samaneh , Esser Karyn A 
Published: February 2024

Abstract

Background
The effects of aging on circadian patterns of behavior are insufficiently described. To address this, we characterized age-specific features of rest-activity rhythms (RAR) in community-dwelling older adults both overall, and in relation, to sociodemographic characteristics.

Methods
We examined cross-sectional associations between RAR and age, sex, race, education, multimorbidity burden, financial, work, martial, health, and smoking status using assessments of older adults with wrist-worn free-living actigraphy data (N = 820, age = 76.4 years, 58.2% women) participating in the Study of Muscle, Mobility, and Aging (SOMMA). RAR parameters were determined by mapping an extension to the traditional cosine curve to activity data. Functional principal component analysis determined variables accounting for variance.

Results
Age was associated with several metrics of dampened RAR; women had stronger and more robust RAR versus men (all p &lt; .05). Total activity (56%) and time of activity (20%) accounted for most of the RAR variance. Compared to the latest decile of acrophase, those in the earliest decile had higher average amplitude (p &lt; .001). Compared to the latest decile of acrophase, those in the earliest and midrange categories had more total activity (p = .02). Being in a married-like relationship and a more stable financial situation were associated with stronger rhythms; higher education was associated with less rhythm strength (all p &lt; .05).

Conclusions
Older age was associated with dampened circadian behavior; behaviors were sexually dimorphic. Some sociodemographic characteristics were associated with circadian behavior. We identified a behavioral phenotype characterized by early time of day of peak activity, high rhythmic amplitude, and more total activity.
Sediment thickness across Australia from passive seismic methods
Authors: Marignier Augustin , Eakin Caroline M , Hejrani Babak , Agrawal Shubham , Hassan Rakib 
Published: February 2024

SUMMARY
Around the world the Earth’s crust is blanketed to various extents by sediment. For continental regions, knowledge of the distribution and thickness of sediments is crucial for a wide range of applications including seismic hazard, resource potential and our ability to constrain the deeper crustal geology. Excellent constraints on the sediment thickness can be obtained from borehole drilling or active seismic surveys. However, these approaches are expensive and impractical in remote continental interiors such as central Australia. Recently, a method for estimating the sediment thickness using passive seismic data, the collection of which is relatively simple and low cost, was developed and applied to seismic stations in South Australia. This method uses receiver functions, specifically the time delay of the P-to-S converted phase generated at the sediment-basement interface, relative to the direct-P arrival, to generate a first-order estimate of the thickness of sediments. In this work, we expand the analysis to the vast array of over 1500 seismic stations across Australia, covering an entire continent and numerous sedimentary basins that span the entire range from Precambrian to present day. We compare with an established yet separate method to estimate the sediment thickness, which utilizes the autocorrelation of the radial receiver functions to ascertain the two-way traveltime of shear waves reverberating in a sedimentary layer. Across the Australian continent the new results match the broad pattern of expected sedimentary features based on the various geological provinces. We are able to delineate the boundaries of many sedimentary basins, such as the Eucla and Murray Basins, which are Cenozoic, and the boundary between the Karumba Basin and the mineral rich Mount Isa Province. Contrasts in seismic delay time across these boundaries are upwards of 0.4 $\, \mathrm{s}$. The delay signal is found to diminish to &lt;0.1 $\, \mathrm{s}$ for older Proterozoic basins, likely due to compaction and metamorphism of the sediments over time. As an application of the method, a comparison with measurements of sediment thickness from local boreholes allows for a straightforward predictive relationship between the delay time and the cover thickness to be defined. This offers future widespread potential, providing a simple and cheap way to characterize the sediment thickness in underexplored areas from passive seismic data.
The role of race and ethnicity in health care crowdfunding: an exploratory analysis
Authors: Machado Sara , Perez Beatrice , Papanicolas Irene 
Published: February 2024

Abstract
Medical crowdfunding is a key source of financing for individuals facing high out-of-pocket costs, including organ-transplant candidates. However, little is known about racial disparities in campaigning activity and outcomes, or how these relate to access to care. In this exploratory, nationwide, cross-sectional study, we examined racial disparities in campaigning activity across states and the association between US campaigners’ race and ethnicity and crowdfunding outcomes using a novel database of organ-transplant–related campaigns, and an algorithm to identify race and ethnicity based on name and geographic location. This analysis suggests that there are racial disparities in individuals’ ability to successfully raise requested funds, with Black and Hispanic campaigners fundraising lower amounts and less likely to achieve their monetary goals. We also found that crowdfunding among White, Black, and Hispanic populations exhibits different patterns of activity at the state level, and in relation to race-specific uninsurance and waitlist additions, highlighting potential differences in fundraising need across the 3 groups. Policy efforts should consider not only how inequalities in fundraising ability for associated costs influence accessibility to care but also how to identify clinical need among minorities.
Reconsidering the Ashida memorandum: the relations between the emergency stationing plan and police reform
Authors: Fujita Goro 
Published: February 2024

Abstract
This article explores the origins of Japan’s security policy after the Asia-Pacific War. During the occupation, the Japanese government decided on the maintenance of US forces in the country after the Japanese Peace Treaty. To explain the rationale behind this, existing studies emphasize the Japanese government’s external security calculations. Highlighting the interaction between Japanese foreign and domestic policies, this article challenges this conventional claim by arguing that internal security calculations strongly influenced the Japanese government’s decision. With the creation of the Ashida memorandum in September 1947 and the expectation that the General Headquarters (GHQ) would allow for stronger police forces, Japanese Foreign Minister Ashida Hitoshi and his staff sought to restrict the stationing of US forces in Japan only to national emergencies. As opposed to such expectation, however, GHQ’s police reform significantly weakened Japan’s internal security capabilities, forcing Tokyo to depend on US forces for dealing with internal communist threats.
Firms’ Inflation Expectations: New Evidence from France
Authors: Savignac Frédérique , Gautier Erwan , Gorodnichenko Yuriy , Coibion Olivier 
Published: February 2024

Abstract
Using a new survey of firms’ inflation expectations in France, we provide novel evidence about the measurement and formation of inflation expectations on the part of firms. First, French firms report inflation expectations with a smaller, but still positive, bias than households and display less disagreement. Second, we characterize the extent and manner in which the wording of questions matters for the measurement of firms’ inflation expectations. Third, we document whether and how the position of the respondent within the firm affects the provided responses. Fourth, because our survey measures firms’ expectations about aggregate and firm-level wage growth along with their inflation expectations, we can show that expectations about wages are even more condensed than firms’ inflation expectations and almost completely uncorrelated with them, indicating that firms perceive little link between price and wage inflation. Finally, an experimental treatment indicates that an exogenous change in firms’ inflation expectations has no effect on their aggregate wage expectations.
Revisiting the role of values in evidence-based education
Authors: Joyce Kathryn E 
Published: February 2024

Abstract
Evidence-based practice in education involves basing decisions about what to do on evidence about the relative effectiveness of available interventions (e.g. programmes, products, practices). This article considers two influential critiques of evidence-based education (EBE) pertaining to its treatment of values. The ‘general critique’ condemns EBE for excluding values from decisions about what to do in education. The ‘specific critique’ condemns EBE for relying on a deterministic view of causality in education which disregards the complex, value-laden nature of educational contexts. I argue that virtually all versions of EBE escape the general critique, including the dominant intervention-centred approach that relies on experimental research to discover ‘what works’, because the predictions EBE aims to support are only one premise in a broader normative argument. Further, intervention-centred EBE can avoid much of the specific values-based critique because it is consistent with a probabilistic, rather than deterministic, understanding of causality. However, I argue that only a context-centred approach to EBE that relies on evidence about the specific target setting from local sources in addition to evidence from theory and mixed methods research can fully address the specific critique by accommodating critics’ descriptive claims about the nature of educational contexts.
A neo-Hegelian theory of Bildung and the problem of a priori intersubjectivism
Authors: Kivelä Ari 
Published: February 2024

Abstract
This article focuses on the implementation of the contemporary neo-Hegelianism of the Pittsburgh School (Robert B. Brandom, John McDowell) to the philosophy of education. Neo-Hegelianism has recently initiated a highly complex discussion about the notion of Bildung and its use in the post metaphysical and naturalized sense. Based on the critique of what is called a priori intersubjectivism, discussed by the main proponents of the Heidelberg School (Dieter Henrich and Manfred Frank), this article aims to address some theoretical and conceptual problems inherent in the educationist reading of neo-Hegelianism. The basic problem of an educationist reading of neo-Hegelianism is that, based on its own premises, it is not capable of comprehending the emergence of self-consciousness and individuality. It would therefore be inadvisable for educationists to (over-)eagerly adopt contemporary neo-Hegelianism, or we should at least be slightly cautious about its potential for the further development of a theory or philosophy of Bildung.
Virus-Specific T Cells for the Treatment of Systemic Infections Following Allogeneic Hematopoietic Cell and Solid Organ Transplantation
Authors: Green Abby , Rubinstein Jeremy D , Grimley Michael , Pfeiffer Thomas 
Published: February 2024

Abstract
Viral infections are a major source of morbidity and mortality in the context of immune deficiency and immunosuppression following allogeneic hematopoietic cell (allo-HCT) and solid organ transplantation (SOT). The pharmacological treatment of viral infections is challenging and often complicated by limited efficacy, the development of resistance, and intolerable side effects. A promising strategy to rapidly restore antiviral immunity is the adoptive transfer of virus-specific T cells (VST). This therapy involves the isolation and ex vivo expansion or direct selection of antigen-specific T cells from healthy seropositive donors, followed by infusion into the patient. This article provides a practical guide to VST therapy by reviewing manufacturing techniques, donor selection, and treatment indications. The safety and efficacy data of VSTs gathered in clinical trials over nearly 30 years is summarized. Current challenges and limitations are discussed, as well as opportunities for further research and development.
Impact of Respiratory Viral Infections in Transplant Recipients
Authors: Bahakel Hannah , Waghmare Alpana , Madan Rebecca Pellet 
Published: February 2024

Abstract
Respiratory viral infections (RVIs) are among the leading cause of morbidity and mortality in pediatric hematopoietic stem cell transplant (HCT) and solid organ transplant (SOT) recipients. Transplant recipients remain at high risk for super imposed bacterial and fungal pneumonia, chronic graft dysfunction, and graft failure as a result of RVIs. Recent multicenter retrospective studies and prospective studies utilizing contemporary molecular diagnostic techniques have better delineated the epidemiology and outcomes of RVIs in pediatric transplant recipients and have advanced the development of preventative vaccines and treatment interventions in this population. In this review, we will define the epidemiology and outcomes of RVIs in SOT and HSCT recipients, describe the available assays for diagnosing a suspected RVI, highlight evolving management and vaccination strategies, review the risk of donor derived RVI in SOT recipients, and discuss considerations for delaying transplantation in the presence of an RVI.