bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Rapid and Simple Analytical Methodology for Therapeutic Drug Monitoring of Selective Serotonin Reuptake Inhibitors in Human Plasma by High‐Pressure Liquid Chromatography
Authors: Gokbulut Cengiz , Korkut Oguzhan , Aksoz Elif , Baykan Hayriye , Akyol Busra Aslan 
Published: February 2025

ABSTRACTThis study aimed to develop a fast, sensitive, and easy chromatographic analysis technique to determine therapeutic plasma concentrations of selective serotonin reuptake inhibitors citalopram, paroxetine, duloxetine, fluvoxamine, fluoxetine, and sertraline) by high‐pressure liquid chromatography. Chromatographic separation was conducted using a Zorbax Eclipse XDB C18 column. The mobile phase consisted of a 20 mM sodium phosphate buffer and acetonitrile in a ratio of 60:40 (v/v), flowing at a rate of 1 mL/min with a gradient program. Detection was achieved through a combination of a photodiode array detector set at 220 nm and a fluorescence detector with excitation at 230 nm and emission at 325 nm. Two different plasma extraction methods, solid‐phase extraction and salt‐assisted liquid‐phase extraction, were studied and compared for their effectiveness in preparing samples for chromatographic analysis of selective serotonin reuptake inhibitors. The detection and determination limits of molecules were 3.0 and 25 ng/mL, respectively. The method was linear (“r2” values were calculated between 0.9961 and 0.9994) over the concentration range of 25–200 ng/mL for all molecules. Accordingly, the recovery rates of the SPE extraction method were calculated in the range of 71.38%–93.60%, intraday repeatability was calculated in the range of 7.18%–10.83%, and interday repeatability was calculated in the range of 8.09%–11.65%. As a result of the salt‐assisted liquid‐phase extraction, retrieval rates are in the range of 74.84%–93.83%, intraday repeatability is 5.86%–7.05%, and interday repeatability is 7.32%–10.80%. Although these two extraction methods, which have been developed and validated, can be used to determine the plasma concentration of the molecules, however obtaining higher recovery rates, consuming less solvent, and being faster and lower cost are the advantages of the salt‐assisted liquid‐phase extraction compared to the solid‐phase extraction method.
Gendered Positions in Technology Education: A Discourse Analysis of Images From Swedish and Finnish Upper Secondary Schools
Authors: Svozil Louise Björlin , Andersson Kristina , Pears Arnold 
Published: February 2025

ABSTRACTInclusivity in education is one of the fundamental objectives of the Swedish national curriculum for compulsory schooling. The accessibility of STEM education to students of different genders is essential in achieving this objective. This paper studies the images Swedish and Finnish upper secondary schools used to promote their university preparatory educational orientations, applying discourse analysis to the body of images. As the discourses imbue the orientations, certain positions are enabled for pupils. These positions prescribe who and what is seen as natural in the orientations. We find substantial differences in how the discourses are represented in the orientations. In the STEM orientations, pupils are constructed as less social than the other orientations. In the images from the technology programme, female pupils have a higher representation than actual enrolment, but in these images, they are less active than their male peers. Moreover, the female technology pupil is positioned as engaged with more creative technology subfields while their male peers engage with electronic experiments. This positioning of the female technology pupil is rather conditioning her presence than creating an attractive educational trajectory for her to assume.
Assessing Soil Quality and Biomass Productivity Under Wastewater Irrigation in the Indian Arid Region
Authors: Singh Genda , Nagora Prem Raj , Haksar Parul , Kulshrestha Shubhi , Rani Abha 
Published: February 2025

ABSTRACTIndiscriminate discharge of effluents in rivers, waterbodies, and croplands is a common practice contaminating food chains through water and soil. Plantations using treated wastewater can help restore degraded lands and reduce soil and environmental pollution. One‐year‐old plantations of Azadirachta indica, Eucalyptus camaldulensis, Prosopis cineraria, Prosopis juliflora, Tamarix aphylla, Salvadora persica, and Salvadora oleoides were irrigated with borewell water at ½ET (Evapotranspiration, I1) and treated wastewater at ½ET (I2), ¾ET (I3), and 1ET (I4) for 4 years (September 2013–September 2017), to assess the remedial impact of these species on soils while reusing wastewater in urban greening and biomass production. Wastewater irrigation enhanced soil pH/EC (<1.0 unit) and SOC and nutrient contents (1.23–13.25‐fold). Such increases were highest (p < 0.05) in 0–15 cm and lowest in 45–60 cm (50%–70%) soil layers. Species types and irrigation levels influenced soil salts and nutrient concentrations. Variations in pH/EC (<0.50 unit), SOC/nutrient contents (1.59–2.11‐fold), and total biomass (3.26‐fold) were greater between species than between irrigation levels (<0.30 unit, 1.14–3.33‐fold and 1.81‐fold variations, respectively). Salt and nutrient uptake were highest in S. oleoides and P. cineraria, medium in T. aphylla and E. camaldulensis, and lowest in S. persica, A. indica, and P. juliflora plots. Leaf mineral contents were below toxic levels. The former three species and S. persica responded by increasing biomass allocation to roots. In contrast, other species maximized root biomass to augment added water and nutrient uptake to sustain growing biomass. Conclusively, tree species influenced soil properties and biomass more notably than irrigation level, where adaptation mechanisms were allocated to/or maximized root biomass. Increased SOC and nutrients, and consequently plant biomass highlight the reuse of treated wastewater in plantations that remediated soil and promoted greenery and biomass in water‐deficient dry areas.
Paddy farmers' awareness and knowledge of agroforestry practices in Siburan, Sarawak
Authors: Mathew Jacklin , Echoh Daniel Ugih anak , Ibrahim Mohamad Hilmi 
Published: February 2025

AbstractRice is an important staple food and the main source of income and livelihood, especially for rural communities in Malaysia. However, the area under rice cultivation in Malaysia has decreased due to poor quality of rice fields due to low productivity and climate change. Agroforestry is a system that combines trees with crops or livestock. It not only counteracts the effects of climate change by increasing the resilience of agriculture, but also combats poverty, food security, and land degradation. The aim of this study was to determine the awareness and perception of rice farmers in Siburan, Sarawak, toward agroforestry. The data for the study were obtained through questionnaire‐based interviews in Kampung Skuduk and Kampung Chupak. Statistical tests were used to analyze and compare the data. Farmers’ knowledge of agroforestry practices was limited, especially among non‐agroforestry practitioners. There is no significant income difference between agroforestry practitioners and non‐agroforestry practitioners as agroforestry is practiced on a small scale and for household consumption as there are no commercial market opportunities for the products. Governmental or non‐governmental organizations should organize educational activities on agroforestry to disseminate information on these practices appropriate to the education level and age group of the target farmers. Awareness raising and information dissemination activities are important as lack of awareness hinders the implementation of agroforestry, for example, through awareness campaigns and training programs on agroforestry. The results of this study will serve as a guide for the authority to plan measures to increase the knowledge and importance of the agroforestry sector and the implementation of agroforestry.
Medicinal and aromatic plants assisted bioremediation of ammonical and bacterial contaminants in aquaponics water
Authors: Arambam Kalpana , Krishnani Kishore Kumar , Singh Rajkumar Debarjeet , Verma Ajit Kumar , Banerjee Kaushik , Chanu Thongam Ibemcha , Kumar Neeraj 
Published: February 2025

AbstractAn experiment was conducted under laboratory conditions to examine the effect of sixteen medicinal and aromatic plants (MAPs), namely Aloe barbadensis, Cymbopogen citratus, Bacopa monnieri, Senna sigueana, Plantado ovata, Asparagus racemosses, Phylanthus emblica, Vitex negundo, Cammiphora wightii, Cymbopogon martini, Andrographis paniculate, Ocimum tenuiflorum, Gymnema sylvestre, Centella asiatica, Adhatoda vasica, and Cyamopsis tetragonoloba in the removal of total ammonia‐N (TAN) from aquaponics water. The different dried and grounded MAPs were added @ 100 mgl−1 into individual conical flasks containing 100 ml aquaponics water (spiked with 5 mgl−1 ammonia) and placed in a shaker. The effectiveness of different MAPs in removing TAN was evaluated at 24 hrs intervals until one of the MAPs achieved a removal rate of over 80%. The study also investigated their potential activity against fish bacterial pathogens viz. Edwardsiella tarda, Escherichia coli, Vibrio parahaemolyticus, Aeromonas hydrophila, and Staphylococcus aureus using the agar well diffusion method. The study indicates a negligible removal of TAN in the first twelve hours for all the MAPs. TAN concentration significantly reduced from 24 hrs for amla‐treated water followed by satavari‐treated water. Within 96 hrs., amla, satavari, and jalbrahmi removed 88.13 ± 0.81%, 79.52 ± 2.27%, and 77.22 ± 0.70 of TAN respectively. Other MAPs showed little effectiveness in removing ammonia, while cluster beans and ardushi increased the ammonia level in the water. Additionally, the methanol extract of amla exhibited strong antibacterial activities against all tested pathogens especially, against E. tarda. This study suggests the potential application of a MAP‐based One‐Health approach for mitigating abiotic and biotic stresses in aquaculture.Practitioner Points
Evaluated 16 different medicinal and aromatic plants (MAPs) for their ammonia removal activity from aquaponics water.
Amla treated water showed the highest ammonia removal followed by Satavaari and Jalbrahmi.
Cluster beans and Ardushi treated water resulted in increasing ammonia levels due to their high nitrogen contents.
Methanolic extract of amla showed bactericidal activity against fish pathogens Edwardsiella tarda, E. coli, Vibrio parahaemolyticus, A. hydrophila, and S. aureus.
Potential applications in developing aquaponics production system of fish with medicinal plants through nutrient cycling and water recycling.
Development and evaluation of the remote passive integrated transponder tag reader for customizable monitoring of wildlife
Authors: Amburgey Staci M. , Prakash Aadithya , Yackel Adams Amy A. , Siers Shane R. , Converse Sarah J. 
Published: February 2025

AbstractIncreasing the quantity and quality of mark‐reencounter data can be important when individual identification data are needed to address research or management questions. Physical recapture methods tend to be labor‐intensive and therefore expensive, while remote detection methods are not easily applied to all taxa or are proprietary and thus difficult to customize. However, partnerships between wildlife scientists and engineers have the potential to provide innovative solutions that improve data collection while reducing costs. We describe a collaborative effort to improve the collection of mark‐reencounter data on an invasive reptile, the brown treesnake (Boiga irregularis). In laboratory trials conducted on Guåhan (CHamoru; Guam in English) in 2021, we assessed the feasibility of detecting snakes fitted with passive integrated transponder (PIT) tags using customized remote PIT‐tag readers (RePTaR) paired with baited snake traps. We evaluated differences in scanning success as a function of snake traits, location of PIT tags within snakes, and the distance of the PIT tag from the reader. We successfully scanned all individuals, on average 529 times but ranging from 3 to 6,436 times, during 12‐hour trials using a designed customizable RePTaR unit. Snake characteristics and marking location explained little of the variability in scanning success, with distance from the reader as the best‐supported covariate. By building cross‐disciplinary partnerships, we can develop customizable technological solutions and provide additional tools with which to address challenges in wildlife research and management.
Defining Violation: Sex-Worker Experiences of Unwanted Incidents
Authors: Brents Barbara G. , Wakefield Chris , Scoular Jane , Sanders Teela , Abel Gillian 
Published: February 2025

Abstract
This chapter explores two primary questions: What range of unwanted contact incidents do sex workers most frequently encounter? Moreover, how does the law influence their understanding, interpretation, and definition of these incidents? We highlight the concept of transactional legal consciousness, distinguishing it from rape consciousness, to explain how sex workers perceive violations within the negotiated context of selling sex. The chapter analyses qualitative and quantitative data on common types of violations, such as payment issues and stealthing, and less common violations involving injury. It also examines the role of legal alienation in shaping sex workers’ responses. The chapter first defines and categorises types of violations, then explores sex workers’ perceptions and interpretations, and finally discusses the implications of transactional legal consciousness in managing these experiences.
Cannabidiol protects lung against inflammation and apoptosis in a rat model of blunt chest trauma via Bax/Bcl-2/Cas-9 signaling pathway
Authors: Emre Akın Süleyman , Mehtap Savran , Cem Doğan , İlter İlhan , Melih Arlıoğlu , Özlem Özmen , Serdar Sezer , Ekrem Çamaş Hasan , Rasih Yazkan 
Published: February 2025

Abstract

Purpose
This study aimed to investigate the hypothesis that cannabidiol (CBD), with known anti-inflammatory and anti-apoptotic effects, would reduce the severity of acute lung injury in pulmonary contusion following blunt chest trauma.

Methods
Forty male Wistar Albino rats were randomly divided into four groups, each consisting of 10 rats: Sham, Trauma, Trauma + CBD, and CBD. The rats were treated with a single dose of 5 mg/kg CBD intraperitoneally 30 min before trauma. Then, the trauma were exposed to a weight of 200 g and a height of 1 m. After sacrifice, the lung tissues were removed for histopathological, immunohistochemical, biochemical, and genetic analyses.

Results
Pulmonary injury of trauma group led to increases in tumor necrosis factor α, caspase-3, caspase-9, Bcl-2-associated X protein expressions, total oxidant status, oxidative stress index levels, and decreases in B-cell lymphoma expression and total antioxidant levels. Additionally, inflammatory cell infiltration, damage-related emphysema, pronounced hyperemia, and increased septal tissue thickness were observed histopathologically. CBD treatment ameliorated all these findings.

Conclusion
CBD reduces lung damage in lung contusions caused by blunt chest trauma through its anti-inflammatory and antiapoptotic effects. More detailed studies investigating other important intracellular pathways are needed.
Poor family finances, family-based adverse childhood experiences, and depressive and behavioral symptoms in adolescence
Authors: Nilsen Sondre Aasen , Radlick Rebecca Lynn , Askeland Kristin Gärtner 
Published: February 2025

Abstract

Purpose
Adverse childhood experiences (ACEs) are a possible pathway through which poor family finances influences adolescents’ behavioral and mental health problems. However, the interrelationship between family finances, ACEs, and behavioral and mental health outcomes in adolescence has received little attention. We aimed to (1) document exposure to family-based ACEs by perceived family finances (PFF), (2) examine how PFF relates to cumulative and pattern-based approaches to ACEs, and (3) assess the direct and interactive associations between PFF and ACEs in relation with behavioral and mental health problems.

Methods
Data stem from the 2017–2019 nationwide Ungdata surveys of adolescents aged 13–15 (n = 12,560). Family-based ACEs were measured by 6 items covering parental alcohol use and intoxication, and intra-familial violence and fighting. The family-based ACEs were used both as a cumulative index score and examined through latent class analysis (LCA) to identify patterns of exposures. Cluster robust linear regression analyses were used to examine additive and interactive associations between PFF, family-based ACEs, and behavioral and depressive symptoms.

Results
Poor (compared to not poor) PFF was significantly associated with more depressive symptoms and behavioral problems. Cumulative and pattern based approaches to family-based ACEs partially and similarly attenuated the association between PFF and mental health outcomes. Mainly, however, PFF and family-based ACEs were independently associated with mental health outcomes and did not interact.

Conclusions
Poor family finances and family-based ACEs co-occur, and both have strong associations with depressive symptoms and behavioral problems in adolescence.
Insider imitation with product differentiation
Authors: d’Andria Diego 
Published: February 2025

Abstract
Online marketplace providers such as Amazon may also offer own-brand products, in this way competing with third-party traders on their platform. Moreover they may exploit nonpublic data on third-party sales to identify opportunities for profit and design their own products, thus engaging in a form of partial imitation that is exclusive to them. Such an asymmetry in the ability to imitate has led to advocating for stricter regulation of online platforms in order to limit their ability to exploit nonpublic data. I propose a dynamic simulation model to study the effects of insider imitation by a platform provider under product differentiation. Using different parametrizations, I am able to show how such a market may evolve in time with or without the presence of insider imitation under different initial conditions. The model also allows to account for subsequent innovation via imitation (which I refer to as copy-and-be-copied dynamics), an aspect not considered by previous studies. These results add to the existing literature and cast further doubts on current regulatory approaches aiming at limiting data exploitation. Results suggest that the presence of insider imitation is unlikely to lead to smaller consumer welfare and larger market concentration and should not be banned on the grounds of standard antitrust concerns.
On a Variational Problem Related to the Cwikel–Lieb–Rozenblum and Lieb–Thirring Inequalities
Authors: Corso Thiago Carvalho , Ried Tobias 
Published: February 2025

Abstract
We explicitly solve a variational problem related to upper bounds on the optimal constants in the Cwikel–Lieb–Rozenblum (CLR) and Lieb–Thirring (LT) inequalities, which has recently been derived in Hundertmark et al. (Invent Math 231:111–167, 2023. https://doi.org/10.1007/s00222-022-01144-7) and Frank et al. (Eur Math Soc 23(8):2583–2600, 2021. https://doi.org/10.1090/pspum/104/01877). We achieve this through a variational characterization of the

$$L^1$$

L
1

norm of the Fourier transform of a function and duality, from which we obtain a reformulation in terms of a variant of the Hadamard three lines lemma. By studying Hardy-like spaces of holomorphic functions in a strip in the complex plane, we are able to provide an analytic formula for the minimizers, and use it to get the best possible upper bounds for the optimal constants in the CLR and LT inequalities achievable by the method of Hundertmark et al. (Invent Math 231:111–167, 2023. https://doi.org/10.1007/s00222-022-01144-7) and Frank et al. (Eur Math Soc 23(8):2583–2600, 2021. https://doi.org/10.1090/pspum/104/01877).
Prevention of infectious complications after transrectal ultrasound-guided prostate biopsy: comparison of povidone-iodine, chlorhexidine, and formalin disinfection
Authors: Başaranoğlu Mert , Nebioğlu Ali , Bozlu Murat , Gökçe Ali , Akbay Erdem 
Published: February 2025

Abstract

Purpose
We aimed to compare the efficacy of three different antiseptic methods to determine the most effective prophylactic approach to prevent infectious complications after transrectal ultrasound-guided prostate biopsy (TRUS-PB). The methods evaluated were transrectal povidone-iodine injection (TRPI), biopsy needle disinfection with chlorhexidine, and biopsy needle disinfection with formalin.

Methods
Between January 2018 and January 2023, 904 patients who underwent TRUS-PB were retrospectively analyzed. All patients had prophylactic antibiotic use and negative urine/rectal culture results. Patients were divided into three groups according to the antiseptic protocol: Group 1 (n = 245) received only TRPI injection into the rectum before biopsy, Group 2 (n = 295) received only chlorhexidine needle disinfection before biopsy, and Group 3 (n = 364) received only formalin needle disinfection before biopsy. The biopsy needles used in our clinic are not single-use and are used on other patients after sterilization. The primary endpoint was the incidence of infectious complications within 30 days post-procedure. Continuous variables were analyzed using the Mann-Whitney U test, while categorical variables were analyzed using the Chi-square test, and post-hoc analysis was applied for pairwise comparisons between groups. Univariate and multivariate logistic regression analysis was performed to evaluate factors associated with postoperative infection.

Results
The overall infection rate was 20.4%. Infection rates were 4.5% in the TRPI group, 16.6% in the chlorhexidine group, and 34.1% in the formalin group (p < 0.001). The TRPI group showed significantly lower rates of all infectious complications compared to other groups. Disinfection of biopsy needles with chlorhexidine was found to be significantly more effective in preventing infectious complications compared to disinfection with formalin (p < 0.001).

Conclusion
TRPI injection before TRUS-PB appears to be more effective in preventing post-biopsy infectious complications compared to needle disinfection with chlorhexidine or formalin. This method may be considered as a preferred antiseptic approach for TRUS-PB procedures.
Helmholtz-x : Parallelized adjoint open source solver for the thermoacoustic Helmholtz equation
Authors: Ekici Ekrem , Falco Stefano , Juniper Matthew P. 
Published: February 2025

Abstract
We create and describe an inhomogeneous Helmholtz equation solver, helmholtz-x, written in an open-source framework. The mesh is generated with Gmsh and the solver uses DOLFINx and UFL from FEniCSx. The performance, validity, stability and extensibility of the solver are demonstrated through several examples of thermoacoustic instability, from the one-dimensional Rijke tube to the three-dimensional MICCA combustor. The implementation of Bloch-type boundary conditions is explained and tested. The adjoint capability of the solver is also shown, and used to obtain derivatives of the eigenvalue with respect to shape parameters. This is exploited to find shape changes that reduce the thermoacoustic growth rate.