bluuebunny/crossref_metadata_2025_split huggingface dataset:
LITERASI ASESMEN: BEKAL GURU UNTUK PENINGKATAN KUALITAS PEMBELAJARAN DI SEKOLAH
Authors: Sari Murni Sapta , Setiawan Deny , Alifiani Alifiani 
Published: March 2024

The existence of a teacher-producer college must have an effect on surrounding schools. Assessment literacy is needed by teachers through authentic assessment to optimize learning in the classroom. The problem of partners related to assessment literacy is in compiling assessments of the planning stage and implementation of learning that is still inappropriate. The objectives of the implementation of this service are as follows: To optimize assessment literacy in learning and to assist Teachers members of the Biology MGMP of SMA in Blitar region in compiling authentic assessments in Biology learning in accordance with the Independent Curriculum. The implementation of activities was carried out at Talun Blitar State High School.The training method in this activity uses the Participatory Training Model. Based on the results of the Teacher Response Percentage, it can be shown that a positive response was obtained from MGMP teachers in the Blitar region. The teachers showed enthusiasm in carrying out literacy assessment assistance activities. Teachers find it helpful to provide mentoring activities to improve the quality of learning in schools
Keywords: literacy assessment, quality of learning, in schools
The SingWell project protocol: the road to understanding the benefits of group singing in older adults
Authors: Good Arla , Kreutz Gunter , Choma Becky , Fiocco Alexandra , Russo Frank 
Published: March 2024

<p>SingWell is an international network of researchers, nongovernmental organizations, and practitioners exploring the potential for choir singing to support well-being among older adults, particularly those living with diseases that are typically associated with aging. In addition to studying the biopsychosocial effects of group singing in established choirs, this project involves tracking newly formed choirs longitudinally. Taking a multi-disciplinary, ability-focused approach, data collection includes structured qualitative interviews, psychosocial questionnaires and biophysiological measurements. Over the long term, the project aims to engage in knowledge mobilization through the dissemination of best practices, and to develop policy initiatives for the social prescription of singing.</p>
Efektivitas Kandungan Ekstrak Kulit Batang Sawo Manila dalam Menekan Pertumbuhan Bakteri Salmonella Typhi
Authors: Gunadi Muh. Agung , Yani Sodiqah  , Musa Inna Mutmainnah , Daeng Kanang Indah Lestari , Syahril Erlin 
Published: March 2024

Demam tifoid adalah infeksi sistemik akibat Salmonella enterica serotype typhi (S. typhi). Di dunia sebanyak 80% kasus tifoid berasal dari daerah kumuh negara Indonesia termasuk. Prevalensi nasional Tifoid (berdasarkan diagnosis tenaga kesehatan dan keluhan responden) adalah 1,60%. Sebanyak 14 provinsi mempunyai prevalensi Tifoid di atas termasuk Sulawesi Selatan. Tanaman obat yang digunakan oleh masyarakat mempunyai kelebihan yaitu memiliki efek samping yang kecil dibandingkan dengan pengobatan kimiawi. Salah satunya adalah sawo manila (Achras zapota L.) yang dijadikan sebagai alternatif obat-obatan herbal. Untuk mengetahui pengaruh pemberian ekstrak kulit batang sawo manila (Achras zapota L.) dalam menekan pertumbuhan Salmonella typhi. Penelitian ini adalah penelitian true experimental post test design dengan menggunakan metode disc diffusion untuk mengetahui efektivitas kandungan ekstrak kulit batang sawo manila (Achras zapota L.) dalam menekan pertumbuhan bakteri salmonella typhi. Dari hasil penelitian menunjukkan bahwa ekstrak kulit batang sawo manila (Achras zapota L.) dengan konsentrasi 50% ialah 14 mm atau intermediat terhadap zona hambat, konsentrasi 100% ialah 16 mm atau intermediat terhadap zona hambat, dan konsentrasi 200% ialah 17 mm atau intermediat terhadap zona hambat. Kontrol positif dengan ciprfloxacin didapatkan zona hambat 35 mm, sehingga memiliki respon penghambatan yang sensitif. Sedangkan kontrol negative yaitu aquadest tidak terbentuk zona hambat untuk pertumbuhan bakteri Salmonella typhi. Ekstrak kulit batang sawo manila (Achras zapota L.) pada konsentrasi 50%, 100%, 200% menunjukkan hasil dengan interpretasi intermediat menghambat pertumbuhan Salmonella typhi dengan efektivitas lemah.
Efeltivitas Air Rebusan Seledri (Apium graveolens L.) Terhadap Penurunan Tekanan Darah di Balai Rehabilitasi Sosial Lanjut Usia Gau Mabaji Gowa
Authors: Chelsea Putri Ningsih  , Sri Wahyu  , Arfah Arni Isnaini , Ida Royani  , Fattah Nurfachanti 
Published: March 2024

Latar belakang: Terapi bagi penderita tekanan darah tinggi dapat diberikan secara farmakolgi dan non farmakologi. Untuk terapi non farmakologi, Penggunaan obat tradisional secara umum dinilai lebih aman dari pada penggunaan obat modern. Seledri atau celery (apium graveolens) merupakan salah satu jenis terapi herbal untuk menangani penyakit hipertensi. Tujuan: Penelitian ini bertujuan untuk mengetahui efektivitas dari air rebusan seledri (apium graveolens L.) dalam menurunkan tekanan darah di Balai Rehabilitasi Sosial Lanjut Usia Gau Mabaji Gowa. Metode penelitian: Penelitian ini dilakukan di Balai Rehabilitasi Sosial Lanjut Usia Gau Mabaji Gowa pada bulan Oktober 2019. Penelitian ini menggunakan metode desain quasy experimen dengan rancangan control grup pre-test post-test design. Terdapat 12 orang sampel yang menderita tekanan darah tinggi dimana 6 orang pada kelompok intervensi dan 6 orang pada kelompok kontrol, karena menggunakan 2 kelompok terapi yaitu kelompok intervensi dan kelompok kontrol. Tekanan darah diukur secara langsung menggunakan spigmomanometer. Hasil uji statistic yang digunakan adalah uji Wilcoxon Signed Ranks Test. Kesimpulan: Kesimpulan hasil uji Wilcoxon Signed Ranks Test menunjukkan terdapat penurunan tekanan darah sistol pada kelompok intervensi (p=0.042) dan diastol (p=0.034), pada kelompok kontrol terjadi penurunan tekanan darah sistol dimana (p=0.066) dan diastol (p=0.705) berarti tida ada penurunan tekanan darah diastol. Berdasarkan kesimpulannya ialah ada pengaruh meminum air rebusan seledri (apium graveolens L.) terhadap penurunan tekanan darah.
Exploring Parents' Attempt to Conduct Home Literacy Practices for Young Learners
Authors: Nurafifah Shafa 
Published: March 2024

In Indonesia, it is quite hard to find a study that raised the topic of home literacy even though the topic is very important to discuss. This research will provide an overview of how parents in Indonesia carry out home literacy practices with their children. Thus, this research aimed to explore the types of home literacy practices by Indonesian parents. The researcher collected the data through an interview via Zoom meeting as a method of this research. The data were transcribed and codified under the theory of Burgees, Hect, and Lonigan (2002). For analyzing the data, the researcher uses a thematic analysis. From the findings, it can be known that the mother played a big role in the sustainability of home literacy. While the father’s role in supporting and teaching the Quran or reciting Surah. There are four roles in conducting home literacy as performed by the parents who had the same level of education and from middle and upper economic background. These are the limiting environment, the literacy interface, the active home literacy environment, and the passive home literacy environment.
Novel bioactive extract from yarrow obtained by the supercritical antisolvent-assisted technique inhibits lipid metabolism in colorectal cancer
Authors: Gómez de Cedrón Marta , Siles-Sanchez Maria de las Nieves , Martín-Hernandez Diego , Jaime Laura , Santoyo Susana , Ramírez de Molina Ana 
Published: March 2024

Background: Altered lipid metabolism in cancer is associated to dissemination and prognosis. Bioactive compounds naturally occurring in Achillea millefolium L. (yarrow) have been reported to exert antitumour activities. Food biotechnology may provide on-demand mixtures of bioactive compounds with complementary activities in cancer treatment.Methods: Supercritical-antisolvent-precipitation (SAS) has been applied to fractionate the bioactive compounds from an Ultrasound-Assisted-Extraction yarrow extract resulting in two extracts with distinct polarity, yarrow-precipitate-(PP) and yarrow-separator-(Sep). Total phenolic content and relevant essential oils have been characterized. Antioxidant, anti-inflammatory and antiproliferative activities have been compared. Moreover, the effect on the inhibition of colorectal cancer cells’ bioenergetics has been evaluated.Results: Yarrow-PP exerted the highest antioxidant activity, even higher than the complete UAE-yarrow extract, meanwhile yarrow-Sep showed the highest anti-inflammatory activity, even higher than the complete UAE-yarrow extract. Interestingly, yarrow-Sep inhibited key lipid metabolic targets in CRC cells extensively shown to be implicated in cancer dissemination and prognosis —SREBF1, FASN, ABCA1 and HMGCR— and epithelial to mesenchymal targets—CDH1, ATP1B1, CDH2 and Vimentin—augmenting cell adhesion.Conclusions: In summary, SAS technology has been applied to provide a novel combination of bioactive compounds, yarrow-Sep, which merits further research to be proposed as a potential complementary nutraceutical in the treatment of CRC.
Effects of non-invasive cervical spinal cord neuromodulation by trans-spinal electrical stimulation on cortico-muscular descending patterns in upper extremity of chronic stroke
Authors: Zhang Jianing , Wang Maner , Alam Monzurul , Zheng Yong-Ping , Ye Fuqiang , Hu Xiaoling 
Published: March 2024

Background: Trans-spinal electrical stimulation (tsES) to the intact spinal cord poststroke may modulate the cortico-muscular control in stroke survivors with diverse lesions in the brain. This work aimed to investigate the immediate effects of tsES on the cortico-muscular descending patterns during voluntary upper extremity (UE) muscle contractions by analyzing cortico-muscular coherence (CMCoh) and electromyography (EMG) in people with chronic stroke.Methods: Twelve chronic stroke participants were recruited to perform wrist-hand extension and flexion tasks at submaximal levels of voluntary contraction for the corresponding agonist flexors and extensors. During the tasks, the tsES was delivered to the cervical spinal cord with rectangular biphasic pulses. Electroencephalography (EEG) data were collected from the sensorimotor cortex, and the EMG data were recorded from both distal and proximal UE muscles. The CMCoh, laterality index (LI) of the peak CMCoh, and EMG activation level parameters under both non-tsES and tsES conditions were compared to evaluate the immediate effects of tsES on the cortico-muscular descending pathway.Results: The CMCoh and LI of peak CMCoh in the agonist distal muscles showed significant increases (p &lt; 0.05) during the wrist-hand extension and flexion tasks with the application of tsES. The EMG activation levels of the antagonist distal muscle during wrist-hand extension were significantly decreased (p &lt; 0.05) with tsES. Additionally, the proximal UE muscles exhibited significant decreases (p &lt; 0.05) in peak CMCoh and EMG activation levels by applying tsES. There was a significant increase (p &lt; 0.05) in LI of peak CMCoh of proximal UE muscles during tsES.Conclusion: The cervical spinal cord neuromodulation via tsES enhanced the residual descending excitatory control, activated the local inhibitory circuits within the spinal cord, and reduced the cortical and proximal muscular compensatory effects. These results suggested the potential of tsES as a supplementary input for improving UE motor functions in stroke rehabilitation.
Revisiting methotrexate and phototrexate Zinc15 library-based derivatives using deep learning in-silico drug design approach
Authors: Siddique Farhan , Anwaar Ahmar , Bashir Maryam , Nadeem Sumaira , Rawat Ravi , Eyupoglu Volkan , Afzal Samina , Bibi Mehvish , Bin Jardan Yousef A. , Bourhia Mohammed 
Published: March 2024

Introduction: Cancer is the second most prevalent cause of mortality in the world, despite the availability of several medications for cancer treatment. Therefore, the cancer research community emphasized on computational techniques to speed up the discovery of novel anticancer drugs.Methods: In the current study, QSAR-based virtual screening was performed on the Zinc15 compound library (271 derivatives of methotrexate (MTX) and phototrexate (PTX)) to predict their inhibitory activity against dihydrofolate reductase (DHFR), a potential anticancer drug target. The deep learning-based ADMET parameters were employed to generate a 2D QSAR model using the multiple linear regression (MPL) methods with Leave-one-out cross-validated (LOO-CV) Q2 and correlation coefficient R2 values as high as 0.77 and 0.81, respectively.Results: From the QSAR model and virtual screening analysis, the top hits (09, 27, 41, 68, 74, 85, 99, 180) exhibited pIC50 ranging from 5.85 to 7.20 with a minimum binding score of -11.6 to -11.0 kcal/mol and were subjected to further investigation. The ADMET attributes using the message-passing neural network (MPNN) model demonstrated the potential of selected hits as an oral medication based on lipophilic profile Log P (0.19-2.69) and bioavailability (76.30% to 78.46%). The clinical toxicity score was 31.24% to 35.30%, with the least toxicity score (8.30%) observed with compound 180. The DFT calculations were carried out to determine the stability, physicochemical parameters and chemical reactivity of selected compounds. The docking results were further validated by 100 ns molecular dynamic simulation analysis.Conclusion: The promising lead compounds found endorsed compared to standard reference drugs MTX and PTX that are best for anticancer activity and can lead to novel therapies after experimental validations. Furthermore, it is suggested to unveil the inhibitory potential of identified hits via in-vitro and in-vivo approaches.
Tumor growth manifested in two-fifths of low-risk papillary thyroid microcarcinoma patients during active surveillance: data from a tertiary center in China
Authors: Le Kehao , Jin Lei , Zhong Fangfang , Huang Xiaojuan , Zhou Liang , Zhou Jiamin , Xie Lei 
Published: March 2024

PurposeTo assess tumor growth using tumor doubling rate (TDR) during active surveillance (AS) in China.MethodsBetween January 2016 and June 2020, a total of 219 patients with low-risk papillary thyroid microcarcinoma (PTMC) (aged 23-75 years) were consecutively enrolled in the AS program.ResultsFour sections of TDR, &gt;0.5, 0.1~0.5, -0.1~0.1 and &lt;-0.1, corresponded with four categories of tumor volume kinetics: rapid growth, slow growth, stable, and decreased size. We found that 10.5% of PTMCs exhibited rapid growth, 33.33% exhibited slow growth, 26.48% were stable, and 29.68% decreased in size. Tumor growth was associated with two factors: age and volume of PTMC at diagnosis. 85.72% of elderly patients (≥ 61 years old) had tumors that remained stable or even shrank and rapidly growing tumors were not found in them. When the volume was small (≤14.13 mm3), the proportion of rapid growth was high (41.67%), whereas when the volume was large (&gt; 179.5 mm3), the proportion of non-growth was 68.75%.ConclusionTDR may be a better metric for evaluating tumor growth in observational PTMCs. A certain proportion of PTMCs grow during the period of AS and tumor growth was associated with age and volume of PTMC at initial diagnosis. Therefore, how to block tumor growth during the AS period, especially for young patients and patients with early-stage PTMC (size ≤ 5 mm), will be a new challenge.
Prevalence and duration of SARS-CoV-2 fecal shedding in breastfeeding dyads following maternal COVID-19 diagnosis
Authors: Pace Ryan M. , King-Nakaoka Elana A. , Morse Andrew G. , Pascoe Kelsey J. , Winquist Anna , Caffé Beatrice , Navarrete Alexandra D. , Lackey Kimberly A. , Pace Christina D.W. , Fehrenkamp Bethaney D. , Smith Caroline B. , Martin Melanie A. , Barbosa-Leiker Celestina , Ley Sylvia H. , McGuire Mark A. , Meehan Courtney L. , Williams Janet E. , McGuire Michelle K. 
Published: March 2024

BackgroundThere is a paucity of data on the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in feces of lactating women with coronavirus disease 2019 (COVID-19) and their breastfed infants as well as associations between fecal shedding and symptomatology.ObjectiveWe examined whether and to what extent SARS-CoV-2 is detectable in the feces of lactating women and their breastfed infants following maternal COVID-19 diagnosis.MethodsThis was a longitudinal study carried out from April 2020 to December 2021 involving 57 breastfeeding maternal-infant dyads: 33 dyads were enrolled within 7 d of maternal COVID-19 diagnosis, and 24 healthy dyads served as controls. Maternal/infant fecal samples were collected by participants, and surveys were administered via telephone over an 8-wk period. Feces were analyzed for SARS-CoV-2 RNA.ResultsSigns/symptoms related to ears, eyes, nose, and throat (EENT); general fatigue/malaise; and cardiopulmonary signs/symptoms were commonly reported among mothers with COVID-19. In infants of mothers with COVID-19, EENT, immunologic, and cardiopulmonary signs/symptoms were most common, but prevalence did not differ from that of infants of control mothers. SARS-CoV-2 RNA was detected in feces of 7 (25%) women with COVID-19 and 10 (30%) of their infants. Duration of fecal shedding ranged from 1-4 wk for both mothers and infants. SARS-CoV-2 RNA was sparsely detected in feces of healthy dyads, with only one mother’s and two infants’ fecal samples testing positive. There was no relationship between frequencies of maternal and infant SARS-CoV-2 fecal shedding (P=0.36), although presence of maternal or infant fever was related to increased likelihood (7-9 times greater, P≤0.04) of fecal shedding in infants of mothers with COVID-19.
Iron metabolism disorder and multiple sclerosis: a comprehensive analysis
Authors: Tang Chao , Yang Jiaxin , Zhu Chaomin , Ding Yaqi , Yang Sushuang , Xu Bingyang , He Dian 
Published: March 2024

BackgroundMultiple sclerosis (MS) is the most common chronic inflammatory disease of the central nervous system. Currently, the pathological mechanisms of MS are not fully understood, but research has suggested that iron metabolism disorder may be associated with the onset and clinical manifestations of MS.Methods and materialsThe study utilized publicly available databases and bioinformatics techniques for gene expression data analysis, including differential expression analysis, weighted correlation network analysis, gene enrichment analysis, and construction of logistic regression models. Subsequently, Mendelian randomization was used to assess the causal relationship between different iron metabolism markers and MS.ResultsThis study identified IREB2, LAMP2, ISCU, ATP6V1G1, ATP13A2, and SKP1 as genes associated with multiple sclerosis (MS) and iron metabolism, establishing their multi-gene diagnostic value for MS with an AUC of 0.83. Additionally, Mendelian randomization analysis revealed a potential causal relationship between transferrin saturation and MS (p=2.22E-02; OR 95%CI=0.86 (0.75, 0.98)), as well as serum transferrin and MS (p=2.18E-04; OR 95%CI=1.22 (1.10, 1.36)).ConclusionThis study comprehensively explored the relationship between iron metabolism and MS through integrated bioinformatics analysis and Mendelian randomization methods. The findings provide important insights for further research into the role of iron metabolism disorder in the pathogenesis of MS and offer crucial theoretical support for the treatment of MS.
Development of The Lupus Clinical Trials Enrollment Decision Aid: a pilot study
Authors: Khalili Leila , Kukafka Rita , Weiner Julia , Inzerillo Sean , Tang Wei , Geraldino-Pardilla Laura , Schmidt Nancyanne , Gartshteyn Yevgeniyia , Alvarez Kathleen , Askanase Anca 
Published: March 2024

IntroductionIn this pilot study, we describe the development of a patient-centered Decision Aid (DA) for participation of SLE clinical trials called “The Lupus Clinical Trials Enrollment DA”.MethodsA draft DA was designed by a development working group using a collaborative, iterative process using the International Patient Decision Aid Standards (IPDAS) guidelines. The approved draft DA was then pilot tested and refined using semi structured interview with 10 lupus providers and 12 SLE patients. Descriptive statistics were calculated. Interviews/surveys were conducted until thematic saturation was achieved. Responses on usefulness were accumulated, and mean usefulness scores were calculated. Feedback from the semi-structured interviews were categorized into several themes as outlined in the results section.ResultsThe definition of treatments, side effects of each option, and expected improvement from each option was outlined. 90% of providers and 91.7% of patients reported that the definition of SOC treatment was clear. Additionally, the expected improvement for SOC (90% of providers, 100% of patients), clinical trial drug (70%, 91.6%), and placebo (70%, 100%) were noted to be clear. Side effects of SOC (80%, 100%), clinical trial drug treatment (80%, 100%), placebo (90%, 100%), were also noted to be clear. 100% of providers and patients thought that the figure outlining pros/cons of participating in clinical trials was appropriate. The mean usefulness scores for the DA were 4.45/5 for providers and 4.67/5 for patients.DiscussionThese data demonstrate that both patients and providers confirm that the newly developed The Lupus Clinical Trials Enrollment DA is useful and easy to use. Qualitative feedback from providers demonstrated concern that aspects of the DA, such as expected improvement and side effects might be unclear to patients; however, patients did not express the same concern in either the quantitative or qualitative feedback.
An endometrial receptivity scoring system evaluated by ultrasonography in patients undergoing frozen–thawed embryo transfer: a prospective cohort study
Authors: Ouyang Yan , Peng Yangqin , Mao Yuyao , Zheng Mingxiang , Gong Fei , Li Yuan , Li Xihong 
Published: March 2024

IntroductionUltrasound has become a routine method for endometrial receptivity (ER) evaluation. However, there is controversy over the independent evaluation values of various ultrasound indicators. Some researchers have designed multi-indicator prediction systems, but their prediction values are uneven. To further our understanding of ER, we conducted this prospective cohort study to estimate ER noninvasively and effectively.MethodsWomen who underwent the first frozen–thawed embryo transfer (FET) cycle from April 2019 to July 2021 were included in the study. On the day of transfer, transvaginal three-dimensional ultrasound examination was performed to evaluate ER, including endometrial thickness, morphology, volume, movement, blood flow and flow index. The clinical pregnancy rate was the primary outcome. Based on whether clinical pregnancy was achieved, enrolled patients were divided into pregnant and nonpregnant groups.ResultsThis study analyzed 197 FET patients (139 pregnancies in total, 70.5%). The protective factors for clinical pregnancy included primary infertility [adjusted odds ratio (aOR), 1.98; 95% confidence interval (CI), 1.01–3.882; p = 0.047] and more frequent endometrial peristalsis (aOR, 1.33; 95% CI, 1.028–1.722; p = 0.03). Scores of 1–2 were assigned according to the relationship between different ultrasound indicators and the clinical pregnancy rate (CPR). The ER score of the patient was the sum of the scores of the 6 items. The ER score of the pregnant group was significantly higher than that of the nonpregnant group (7.40 ± 1.73 vs. 6.33 ± 1.99, p = 0.001). The CPR increased with an increasing ER score. The CPR in the ER &lt; 6 group was significantly lower than that in the ER &gt;6 group (45.5% vs. 75.6%, p = 0.001).ConclusionA noninvasive ultrasound scoring system for ER was proposed. This system may provide a non-invasive guidance perspective, in conjunction with invasive assessments currently used in clinical practice, to achieve more effective embryo transfer.