bluuebunny/crossref_metadata_2025_split huggingface dataset:
Carcinoembryonic antigen in patients with neuroblastoma
Authors: Wang Jaw J. , Sinks Lucius F. , Chu T. Ming 
Published: February 2007

AbstractCarcinoembryonic antigen (CEA) was studied in the plasma of 17 patients (2 months to 18 years old) with neuroblastoma by means of a radioimmunoassay that detects an antigenic site in the CEA molecule at low ionic strengths. Elevated levels (greater than 2.5 nanograms per ml) of CEA were observed in plasma specimens from 8 or 9 patients with active neuroblastoma. Following successful therapy in 2 patients, CEA returned to normal in both. Disease remained active in 5 patients; their serial titers showed continued elevation. Seven of 8 patients with no evidence of active disease had CEA lèvels within the normal range. Ten children with nonneoplastic disease (2 to 10 years old) had normal levels of antigen (0‐2.0 ng). This observation indicates that neuroblastoma may also possess the CEA previously detected in patients with other ectodermally derived cancers. The antigen appears to correlate with clinical activity of the neuroblastoma and may be helpful in assessment of the efficacy of therapy and prognosis in these patients.
Detection and diagnosis of oral malignancies
Authors: Greene George W. 
Published: February 2007

AbstractOral cancer is a really serious problem and the control of it rests with physicians and dentists who are able to detect cancer at an early stage, that is, at a time when proper management and treatment of the case will cure the patient with a minimum amount of deformity. Oral cancer comprises somewhere between 6 and 7% If all malignant tumors. Detection depends upon the ability of the clinician to be observant and to recognize any abnormality in the region of the head and neck. Recognition is best accomplished by a thorough oral examination. Diagnosis may be possible by clinical observation or x‐ray, however diagnostic aids such as the use of exfoliative cytology, toluidine blue (Niebel and Chomet, 1964; Shedd, et al., 1965; Myers, 1970) and various forms of biopsy are most useful for a definitive diagnosis.The methods used in detection and diagnosis of oral malignancy were discussed and indications and contra‐indications for their use were noted. The proper management and referral were also emphasized since this is an important aspect in the treatment of the oral cancer problem.
Pelvic neoplasms causing pain
Authors: Geelhoed Glenn W. , Ketcham Alfred S. 
Published: February 2007

AbstractThe following is a discussion of dyspareunia and its role as an aid to diagnosing pelvic neoplasms. The great majority of cases of dyspareunia are psychosomatic in origin, and in a large proportion of the remaining cases, painful coitus is an indicator of benign problems. Nevertheless, painful coitus is a symptom which requires careful pelvic examination to rule out the possibility of pelvic neoplasm and to discover treatable causes of dyspareunia.
Prognostic factors in Hodgkin's disease
Authors: Say Carlos , Lee Yeu‐Tsu N. , Hori Jose , Spratt John S. 
Published: February 2007

AbstractThe clinical records and treatment results of 163 patients with Hodgkin's disease, who were seen at Ellis Fischel State Cancer Hospital (EFSCH) between 1940 and 1971, were reviewed and analyzed. More than 200 clinical and histological variables were recorded for each case of Hodgkin's disease, including details of radiotherapy and chemotherapy. Statistical studies were carried out in order to evaluate the independent prognosis significance of each of these factors.All of the lesions were reclassified according to the Lukes proposal which was modified and recommended at the 1965 Rye classification (except for hepatomegaly which was included in Stage IV).This is a retrospective study, and the modern techniques of staging were rarely used in pretreatment studies (since 1965, only ten patients have had an abdominal exploration). The basic work‐up consisted of a complete blood count, urinalysis, blood type, chest X ray, and EKG. Lymphangiogram and radioisotope liver scans were used on less than 10% of the patients. About 30% of the patients had gastrointestinal X rays and 70% had IVP. Bone marrow biopsies ‐ the majority of which were done by needle aspiration ‐ were obtained for approximately 50% of the patients.Clinical stage, histological type, and presence or absence of systemic symptoms appeared to be the most significant prognostic factors. The classification of systemic symptoms according to the criteria of either the Rye or Ann Arbor conferences showed no particular difference in determining the survival rate. Among the systemic symptoms, fever appeared to be the most important for survival rate. Survival rates were higher in nonanemic and nonlymphocytopenic patients. Eosinophilia, blood group, and Rh factor had no prognostic significance. The relapse‐free interval was an important indicator of long‐term prognosis. The unfavorable influence of relapse in ultimate prognosis was clearly seen; however, the extent of the relapse site was shown to have no significant influence on survival.
By‐pass anastomosis of intrahepatic duct to the gallbladder
Authors: Scanlon Edward F. , Oviedo Miguel A. 
Published: February 2007

AbstractObstructiori of the extrahepatic bile ducts by primary or metastatic carcinoma can sometimes be difficult to relieve. Frequently there is an inadequate length of normal duct proximal to the obstruction to permit an anastomosis. A by‐pass anastomosis between a dilated right hepatic biliary radicle and the gallbladder is a simple and satisfactory method of relieving the jaundice. This can be accomplished by using a T‐tube as a stent; a vein graft over the T‐tube limb in the liver seems to improve the result.
Investigation of carbohydrate metabolism and somatomedin in osteosarcoma patients
Authors: Scranton Pierce E. , McMaster James H. , Kenny Frederic M. , Foley Thomas P. , Taylor Floyd H. 
Published: February 2007

AbstractAltered carbohydrate metabolism associated with fibrosarcomas and chondrosarcomas has been well‐documented in past literature. This report describes abnormal carbohydrate metabolism in 2 osteosarcoma patients, and abnormalities in growth hormone and somatomedin serum levels. Experimental evidence is presented showing in vitro suppression of osteosarcoma tumor cell proliferation by 17β Estradiol. Estrogen inhibition of linear bone growth, cartilage proliferation, and somatomedin is discussed with reference to possible estrogen therapy in osteosarcoma.
The effect of surgery and pretreatment or posttreatment adjuvant chemotherapy on primary tumor growth in an animal model
Authors: Straus Marc J. , Sege Vivian , Choi Sung C. 
Published: February 2007

AbstractThe Ca755 solid tumor in the C57B1 mouse has been used as a model to study the interrelationship of surgery and adjuvant chemotherapy on primary tumor growth.Surgery was performed on various days after tumor implantation. Surgical mortality increased with delay in surgery. The mean survival time (MST) was significantly increased by surgery. An increased cure rate in mice with late surgery may be due to immunological factors.Pretreatment cytoxan chemotherapy prior to a number of surgical days on the most effective schedule increased MST in the later surgical days primarily due to shrinkage of tumor and a diminished surgical mortality. Posttreatment chemotherapy significantly increased MST primarily on the basis of reducing tumor cell population after surgery and increasing both the cure rate and the time until death of those mice dying of regrowth of tumor.Optimal chemotherapy alone significantly increased MST compared to untreated controls. Optimal postsurgery chemotherapy increased survival longer than the additive increase of chemotherapy alone and surgery alone.This paper illustrates relationships between day of surgery dose and schedule of chemotherapy and effect on various measurable parameters. The results can best be understood in relationship to each other. It is suggested that adjuvant chemotherapy has specific definable benefits. It is apparent from human studies that carefully devised designs which consider these interrelationships are necessary if optimal therapeutic results are to be achieved.
Impaired cell‐mediated immunity in patients with cancer
Authors: Buda Joseph A. , Suciu‐Foca N. , Blomain Eric , McManus Susan , Reemtsma Keith 
Published: February 2007

AbstractThe ability of peripheral blood lymphocytes to respond in vitro to phytohemagglutinin (PHA) and to allogeneic cells in mixed leukocyte reaction (MLC) was studied in 85 patients with cancer and in 50 healthy controls. The effect produced by sera from cancer patients on in vitro lymphocyte blastogenesis was tested on autologous cells and on homologous cells from a constant panel of 10 normal volunteers.Patients with cancer showed a distinct deficiency of cellular immune responsiveness reflected in a stage‐related impairment of PHA and MLC reactivity. This deficiency seems at least partially attributable to the presence of lymphocyte depressive factors in cancer sera, since such sera reduced the reactivity of both autologous and normal homologous lymphocytes to a level that was significantly lower than that found in the presence of pooled normal serum. The inhibitory activity of cancer sera was directly related to the extent of the neoplasia.
Apparent resistance of the integument of the invertebrate Lehmannia poirieri to production of papillary tumors by a known chemical carcinogen
Authors: Arcadi John A. 
Published: February 2007

AbstractPapillary tumors of the skin of the land invertebrate Lehmannia poirieri (a gastropod) could not be induced by using a potent vertebrate carcinogen. With the same agent 7,12‐dimethylbenz (a) anthracene papillary tumors can readily be induced in mice. The resistance of this invertebrate to a known vertebrate carcinogen is discussed and the ramifications are conjectured.
Effects of subcutaneously implanted sustained‐release cyclophosphamide capsules on walker 256 solid rat tumor
Authors: Fu J. C. , Moyer D. L. , Cuevas J. , Young R. , Elshire D. 
Published: February 2007

AbstractComplete regression of Walker 256 solid rat tumor was brought about by the subcutaneous implantation of a single sustained‐release cyclophosphamide capsule adjacent to the tumor mass. Untreated control animals died within 3 weeks after receiving the tumor with large necrotic masses. Rats with sustained‐release capsules experienced complete tumor regression within 28 days. Upon examination, the tissues around the previous tumor mass had regenerated, and no viable tumor cells could be found in the area where the previous tumor mass was. Around the implanted sustained‐release cyclophosphamide capsule a fibrous sheath has developed over the 3 weeks it was in situ. This study suggests an alternate means of cytoxic drug administration in the treatment of solid tumors in experimental animals.
Carcinogenic and possible mutagenic effects of stilboestrol in offspring exposed in utero
Authors: Bishun N. P. , Smith N. S. , Williams D. C. , Raven R. W. 
Published: February 2007

AbstractThe relevant literature has been reviewed and it appears that there is no doubt that in utero exposure to stilboestrol is related to the eventual development of vaginal adenocarcinoma in young females. Although cancers of other types are also prevalent, the incidence is not great and may be related to other types of drugs taken during pregnancy. The review attempts to correlate the genetic effects with the abnormal development, but on account of the scarcity of data such correlation is not possible. Further work on the genetic effects and the development of the lower genital tract in the female needs to be carried out.
Simultaneous radiation and drug therapy: Tumor response and toxicity
Authors: Friedman Moshe , Afridi Muhammed Ali , Douglass Harold , Wallace James H. 
Published: February 2007

AbstractThree patients who received simultaneous radiation and chemotherapy are described. Increased tumor response and enhanced radiation reaction were observed. Simultaneous drug and radiation therapy may prove to be the treatment of choice for particular malignant tumors. More data concerning the magnitude of the toxic effects when 2 modalities are used in conjunction is needed. Dose adjustments will be required for each modality to allow for optimal damage to the tumor with minimal and acceptable adverse reaction in the normal tissue.
Visualization of breast lesions with an advanced ultrasonic device: Results of a pilot study
Authors: Weiss L. , Rosner D. , Glenn W. E. 
Published: February 2007

AbstractA pilot study is described in which a new design of a sensitive ultrasonic device was used to visualize breast lesions in nine patients. The results were in general accord with clinical, histologic, and x‐ray examinations, although ultrasound was superior to x‐ray mammography in the visualization of discrete cysts in breasts having a “dense” background.As the device provides an indication of the capabilities of ultrasonic equipment which will be generally available within the next two years, projections are made on the impact of this equipment on the earlier diagnosis and prognosis of cancer, together with a discussion of the negligible radiation bio‐hazards posed by devices of this type, in the light of present knowledge.
Effect of infusion chemotherapy and hepatic artery ligation on normal liver: Experimental study in the cat
Authors: Delk Sam , El‐Domeiri Ali A. 
Published: February 2007

AbstractThe effects of arterial infusion with chemotherapy alone or in combination with hepatic artery ligation on the normal liver of the cat were studied. Early in the course of treatment catas receiving chemotherapy infusion only appeared sicker than animals in other groups. Yet only 1 of 5 cats was dead at 12 weeks. In contrast, 4 of 6 animals that had hepatic artery ligation and chemotherapy infusion, and 3 of 6 that had ligation of the hepatic artery only, died during the same period of follow‐up. Progressive liver damage after dearterialization accounted for the high mortality rate. Histologic examination of liver biopsies taken from animals in these latter groups revealed marked destruction of the parenchyma. These changes were more extensive in animals treated by a combination of hepatic artery ligation and chemotherapy infusion. To avoid the injurious effects of permanent interruption of the hepatic arterial flow on normal liver tissue an alternative method of hepatic dearterialization is currently under investigation.
Reduction of metastatic rate by immunotherapy: A comparison of the immunogenic properties of metastasizing tumor cells versus tumor cells in the primary mass
Authors: Liotta Lance A. , Catanzaro Phillip J. , Kleinerman Jerome 
Published: February 2007

AbstractThe vasculature of a poorly immunogenic, highly metastatic transplantable fibrosarcoma (T‐241) maintained in the femoral muscle of C57BL/6J mice was perfused. This permitted collection of tumor cells which had invaded into the tumor vascular channels (ie, metastasizing tumor cells). Also collected as a separate population were tumor cells from the primary tumor mass. Immunization was carried out with these cell populations in conjunction with BCG and the effect on the growth of primary tumor and metastatic rate was evaluated following rechallenge with unfractionated tumor cells. The rate of tumor growth at the primary site was not affected by any of the immunization schedules. However, immunization with venous effluent cells (metastasizing tumor cells) and BCG was two times more effective in reducing the number of pulmonary metastases than immunization using tumor cells isolated from the primary tumor mass. Passively transferred spleen cells from donors immunized with the cell populations listed above had exactly the same effect, that is, no effect on the growth of the primary tumor, but a dramatic reduction in the metastatic rate when effluent tumor cells were used to immunize cell donors. The data point to an antigenic heterogeneity with this particular transplantable tumor.
Autoantigens in breast cancer tissue
Authors: Humphrey L. J. , Volenec P. J. , Estes N. C. , Volenec F. J. 
Published: February 2007

AbstractTwo antigens in specimens of human breast cancer have been identified as autoantigens. One antigen appears to be an IgG Fc fragment; the other, an IgG Fab fragment. Antibodies in sera of cancer patients directed against these antigens have also been identified. These autoantibodies occur in patients with breast cancer as well as other cancers, and rarely in patients with non‐cancerous disease or in people screened in a detection center for breast diseases. The breast cancer patient found to have antibody directed against the IgG Fab antigen falls into a group that has improved two‐year survival statistics over groups of patients who lack this antibody.
Early tissue distribution of therapeutic 131I in a patient with thyrotoxicosis
Authors: Vachal E. , Wegst A. , Preston D. , Tomita T. 
Published: February 2007

AbstractA therapeutic dose of 131I was given to a 53‐year‐old man with thyrotoxicosis three and one‐half hours prior to death. The distribution of 131I in the thyroid gland was studied by autoradiography, and the radioactivity in various fresh tissues was measured. Radioactivity was distributed evenly throughout the colloid;small amounts were present in follicular cells. Radioactivity was not localized to the periphery of colloid follicles as observed in an earlier report. Papillary projections were associated with increased radioactivity. Decreased ratioactivity was associated with oxyphilic cells. Measurement of 131I in individual tissues showed that per gram of tissue the thyroid gland contained approximately 50 times that of intestine and spleen and approximately 100 times that of liver and bone.
Effect of preoperative intralesional BCG and postoperative 5‐FU chemotherapy in three adenocarcinoma lines in rats
Authors: Lee Yeu‐Tsu N. 
Published: February 2007

AbstractIn No. 13762 mammary adenocarcinoma, it has been shown that the combination of tumor infiltration with BCG and of subsequent surgery is more curative than either treatment modality alone. And the administration of postoperative systemic 5‐fluorouracil(5‐FU) is equally effective in eliminating the visceral metastasis and prolonging the host survival. In the experiments reported here, two other spontaneously metastasizing adenocarcinoma lines were similarly treated. Postoperative 5‐FU chemotherapy, but not intralesional BCG, significantly improved survival duration of rats with SMT‐2A mammary adenocarcinoma, but neither chemotherapy nor BCG immunotherapy was effective in the new colonic adenocarcinoma line.
Tumorlytic activity of autochthonous blood fractions upon spontaneous murine mammary carcinomas
Authors: Friedman Frank 
Published: February 2007

AbstractAutologous blood fractions of mice bearing spontaneous mammary carcinoma were assessed for their autotumorlytic capability. In the 180 animals evaluated, it appears that in the blood of these tumor animals there coexists at least two types of biological antagonists ie, one which is capable of inducing tumor breakdown and necrosis and the other which apparently nullifies this action. These results seem additive to the growing body of evidence that the tumorous host has the capability of destroying its own neoplasm but some negative homeostatic mechanism seems to favor the tumor rather than the host.
Spontaneous regression of a pulmonary metastasis after nephrectomy for renal cell carcinoma
Authors: Vizel Monique , Oster Martin W. , Austin John H. M. 
Published: February 2007

AbstractRegressions of metastases following nephrectomy for renal cell carcinoma are rare. Most reported cases have involved pulmonary metastases. Hormonal and immunological mechanisms have been postulated. A case is described of a pulmonary metastasis which regressed after nephrectomy and which failed to recur despite the later appearance of new sites of pulmonary metastases. The literature is reviewed.
Hodgkin disease in monozygotic twins: A case report
Authors: Gracz Kenneth , Kofman Sydney , Economou Steven G. 
Published: February 2007

AbstractPresented are the case histories of monozygotic male twins concordant for Hodgkin disease. This is believed to be the third such case report in the world literature. Its significance as it relates to the role of heredity in carcinogenesis is discussed.
Para‐aortic node biopsy in staging women with cervical, ovarian and endometrial carcinoma: A review
Authors: Piver M. Steven 
Published: February 2007

AbstractIn women with gynecologic malignancies the para‐aortic lymph nodes are not routinely treated. However, pretherapy surgical staging has now disclosed an incidence of para‐aortic node metastasis of 10.3% for presumed stage I and II ovarian cancer, 8.0% for stage I endometrial carcinoma, and 23.5% for stage II, III, and IV cervical cancer. Prospective trials to evaluate therapy directed to the para‐aortic nodes in women with early ovarian and endometrial carcinoma have not been carried out. Moreover, the results of high dose irradiation to biopsy proven metastasis to the aortic lymph nodes from cervical cancer has resulted in only 11.9% survival without recurrence at two years.
Asymptomatic retroperitoneal dermoid cyst (benign cystic teratoma) in a 64‐year‐old male: An autopsy case report
Authors: Honoré Louis H. 
Published: February 2007

AbstractA primary retroperitoneal dermoid cyst (benign cystic teratoma) is described in a 64‐year‐old male, who died postoperatively of a leaking grafted abdominal aortic aneurysm. The asymptomatic tumor, measuring 12 cm in greatest diameter, showed an extensive sclerosing lipogranulomatous reaction in its wall and wide‐spread adhesions to the vital organs in the right hypochondrium. This patient is the oldest on record with such a lesion.
Characterization of melanoma cell membrane tumor‐associated antigens using xenoserum, alloserum, and autoserum: I. immunofluorescence
Authors: Mutzner P. Alfred , Stuhlmiller Gary M. , Seigler H. F. 
Published: February 2007

AbstractXenoantiserum, alloantiserum, and autoantiserum prepared against human melanoma cells from cell lines maintained in tissue culture were evaluated by indirect immunofluorescence (ind IF) for their content of antibodies reactive with melanoma cell membrane tumor‐associated antigens (TAA). Following absorptions which removed all detectable anti‐human species, anti‐RBC, and anti‐HLA antigen activity, the antisera were tested against a panel of human cell lines. Three apparently distinct melanoma‐associated cell membrane antigens were detected. The first of these was present on all human cells maintained in tissue culture including cells of both malignant and nonmalignant origin. The second antigen was expressed on all cells of malignant origin and also by fetal fibroblasts. The third antigen was detectable only on melanoma cells and was expressed by a majority of the melanomas tested. No evidence was obtained to suggest the presence of melanoma TAA unique to a single melanoma cell line. Marked differences were observed in the antigenic profile detected by the three antisera.