bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transformative skeletal motion analysis: optimization of exercise training and injury prevention through graph neural networks
Authors: Zhu Jiaju , Ye Zijun , Ren Meixue , Ma Guodong 
Published: March 2024

IntroductionExercise is pivotal for maintaining physical health in contemporary society. However, improper postures and movements during exercise can result in sports injuries, underscoring the significance of skeletal motion analysis. This research aims to leverage advanced technologies such as Transformer, Graph Neural Networks (GNNs), and Generative Adversarial Networks (GANs) to optimize sports training and mitigate the risk of injuries.MethodsThe study begins by employing a Transformer network to model skeletal motion sequences, facilitating the capture of global correlation information. Subsequently, a Graph Neural Network is utilized to delve into local motion features, enabling a deeper understanding of joint relationships. To enhance the model's robustness and adaptability, a Generative Adversarial Network is introduced, utilizing adversarial training to generate more realistic and diverse motion sequences.ResultsIn the experimental phase, skeletal motion datasets from various cohorts, including professional athletes and fitness enthusiasts, are utilized for validation. Comparative analysis against traditional methods demonstrates significant enhancements in specificity, accuracy, recall, and F1-score. Notably, specificity increases by ~5%, accuracy reaches around 90%, recall improves to around 91%, and the F1-score exceeds 89%.DiscussionThe proposed skeletal motion analysis method, leveraging Transformer and Graph Neural Networks, proves successful in optimizing exercise training and preventing injuries. By effectively amalgamating global and local information and integrating Generative Adversarial Networks, the method excels in capturing motion features and enhancing precision and adaptability. Future research endeavors will focus on further advancing this methodology to provide more robust technological support for healthy exercise practices.
Ultra-processed food consumption and chronic kidney disease risk: a systematic review and dose–response meta-analysis
Authors: He Xingzhen , Zhang Xiaoyan , Si Caijuan , Feng Yuliang , Zhu Qin , Li Songtao , Shu Long 
Published: March 2024

BackgroundHigh intake of ultra-processed food (UPF) has been associated with increased risk of chronic kidney disease(CKD), but the results remain inconsistent. We therefore performed this systematic review and dose–response meta-analysis of observational studies that shed light on the association between UPF consumption and the risk of CKD.MethodsA systematic literature search of PubMed, Embase, Web of Science, Scopus and China National Knowledge Infrastructure (CNKI) databases was carried out to find the eligible articles published up to October 31, 2023. Random-effects or fixed-effects models were used to pool the relative risks(RRs) and their 95% confidence intervals (CIs).The potential sources of heterogeneity across studies were examined using the Cochran’s Q test and I-square(I2). Publication bias was examined using the visual inspection of asymmetry in funnel plots and quantified by Begg’s and Egger’s tests.ResultsEight studies (six cohort and two cross-sectional studies) exploring the association between UPF consumption and risk of CKD, were included in the final analysis. The pooled analyses revealed that high consumption of UPF was associated with an increased risk of CKD (RR = 1.25; 95%CI: 1.09–1.42, p &lt; 0.0001). Moreover, a 10% increase of UPF consumption was associated with a 7% higher risk of CKD (RR = 1.07; 95%CI: 1.04–1.10, p &lt; 0.001). Dose–response analysis of all included studies showed a linear association between UPF consumption and the risk of CKD (RR = 1.02; 95%CI:0.99–1.05, Pdose–response = 0.178, Pnonlinearity = 0.843).ConclusionOur findings indicate that high consumption of UPF is significantly associated with an increased risk of CKD. Future research with prospective design is required to confirm this positive association.Systematic review registration: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023478483, PROSPERO identifier CRD42023478483.
A comprehensive review of the botany, phytochemistry, pharmacology, and toxicology of Murrayae Folium et Cacumen
Authors: Qi Yue , Wang Lin , Wang Na , Wang Siyi , Zhu Xu , Zhao Tie , Jiang Qinghua 
Published: March 2024

Ethnopharmacological relevance: Murrayae Folium et Cacumen (MFC) is a plant considered to be a traditional Chinese medicine with culinary value as well. The dry leaves and twigs of Murraya paniculata and M. exotica are used to treat stomach aches, rheumatism, toothaches, swelling, and insect and snake bites. They are also used to prepare spicy chicken dishes.Aim of the review: This review comprehensively summarizes the available information on the botanical characterization, phytochemistry, pharmacological activities, pharmacodynamics, pharmacokinetics, and toxicity of MFC.Methods: Relevant scientific literature up to August 2023 was included in the study. Chinese and English studies on MFC were collected from databases, including PubMed, Elsevier, Web of Science, Springer, Science Direct, Wiley, ACS, and CNKI (Chinese). Doctoral and Master’s dissertations were also included.Results: In total, 720 compounds have been identified and reported in the literature, including flavonoids, coumarins, alkaloids, sterols, phenylpropenols, organic acids, spirocyclopentenones, and volatile oils. Flavonoids and coumarins are the two most important bioactive compounds responsible for these pharmacological activities. MFC has anti-inflammatory, anti-bacterial, anti-microbial, anti-diabetic, anti-tumor, anti-oxidant, anti-depressant, potential anti-Alzheimer’s disease, chondroprotective, and analgesic properties. The pharmacological effects include interrupting the STAT3/NF-κB/COX-2 and EGFR signaling pathways, downregulating EpCAM expression, inhibiting NF-κB and ERK signals, inhibiting the EP/cAMP/PKA signaling pathway and miR-29a/Wnt/β-catenin signaling activity, and upregulating Foxo3a expression.Conclusion: This review demonstrates that the chemical constituents, pharmacological activities, pharmacodynamics, pharmacokinetics, and toxicity of MFC support its use in traditional Chinese botanical medicines. MFC contains a wide range of chemical compounds. Flavonoids and coumarins promote strong pharmacological activity and, are low-toxicity natural phytomedicines that are widely used in medicine, food, ornamentation, and cosmetics, making MFC a promising compound for development and use in the treatment of several medical conditions.
Phytochemical analysis and anticancer effect of Camellia oleifera bud ethanol extract in non-small cell lung cancer A549 cells
Authors: Niu Jingming , Jia Xiaoyan , Yang Nian , Ran Yuanquan , Wu Xia , Ding Furong , Tang Dongxin , Tian Minyi 
Published: March 2024

Camellia oleifera is a medicine food homology plant widely cultivated in the Yangtze River Basin and southern China due to its camellia oil. Camellia oleifera bud and fruit exist simultaneously, and its bud is largely discarded as waste. However, C. oleifera bud has been used in traditional Chinese medicine to treat a variety of ailments. Thus, the purpose of this study was to identify the chemical components of C. oleifera bud ethanol extract (EE) and first evaluate its anticancer effects in non-small cell lung cancer A549 cells. Based on UHPLC-Q-Orbitrap-MS analysis, seventy components were identified. For anticancer activity, C. oleifera bud EE had remarkable cytotoxic effect on non-small cell lung cancer A549 (IC50: 57.53 ± 1.54 μg/mL) and NCI-H1299 (IC50: 131.67 ± 4.32 μg/mL) cells, while showed lower cytotoxicity on non-cancerous MRC-5 (IC50 &gt; 320 μg/mL) and L929 (IC50: 179.84 ± 1.08 μg/mL) cells. It dramatically inhibited the proliferation of A549 cells by inducing cell cycle arrest at the G1 phase. Additionally, it induced apoptosis in A549 cells through a mitochondria-mediated pathway, which decreased mitochondrial membrane potential, upregulated Bax, activated caspase 9 and caspase 3, and resulted in PARP cleavage. Wound healing and transwell invasion assays demonstrated that C. oleifera bud EE inhibited the migration and invasion of A549 cells in a dose-dependent manner. The above findings indicated that C. oleifera bud EE revealed notable anticancer effects by inhibiting proliferation, inducing apoptosis, and suppressing migration and invasion of A549 cells. Hence, C. oleifera bud ethanol extract could serve as a new source of natural anticancer drugs.
Integrative transcript to proteome analysis of barley during Ramularia collo-cygni leaf spot development identified several proteins that are related to fungal recognition and infection responses
Authors: Lemcke René , Kamble Manoj , Schneider Sebastian , Lyngkjær Michael F. , Radutoiu Simona , Wienkoop Stefanie 
Published: March 2024

IntroductionRamularia leaf spot (RLS) disease is a growing threat to barley cultivation, but with no substantial resistance identified to date. Similarly, the understanding of the lifestyle of Ramularia collo-cygni (Rcc) and the prediction of RLS outbreak severity remain challenging, with Rcc displaying a rather untypical long endophytic phase and a sudden change to a necrotrophic lifestyle. The aim of this study was to provide further insights into the defense dynamics during the different stages of colonization and infection in barley in order to identify potential targets for resistance breeding.MethodsUtilizing the strength of proteomics in understanding plant–pathogen interactions, we performed an integrative analysis of a published transcriptome dataset with a parallel generated proteome dataset. Therefore, we included two spring barley cultivars with contrasting susceptibilities to Rcc and two fungal isolates causing different levels of RLS symptoms.ResultsInterestingly, early responses in the pathogen recognition phase of the host were driven by strong responses differing between isolates. An important enzyme in this process is a xylanase inhibitor, which protected the plant from cell wall degradation by the fungal xylanase. At later time points, the differences were driven by cultivar-specific responses, affecting mostly features contributing to the pathogenesis- and senescence-related pathways or photosynthesis.DiscussionThis supports the hypothesis of a hemibiotrophic lifestyle of Rcc, with slight differences in trophism of the two analyzed isolates. The integration of these data modalities highlights a strength of protein-level analysis in understanding plant–pathogen interactions and reveals new features involved in fungal recognition and susceptibility in barley cultivars.
A comparative study on fundamental movement skills among children with autism spectrum disorder and typically developing children aged 7–10
Authors: Dong Liangshan , Fan Rong , Shen Bo , Bo Jin , Pang Yanli , Song Yu 
Published: March 2024

BackgroundAutism Spectrum Disorder (ASD) is a neurodevelopmental condition with unique differences in social interaction, communication, and a spectrum of behavioral characteristics. In the past, motor disturbance in individuals with ASD has not been considered a significant core deficit due to the predominant focus on sociability and communication issues. However, recent studies indicate that motor deficits are indeed associated with the fundamental symptoms of ASD. As there is limited research on the motor behavior of children with ASD, particularly in China, the objective of this study is to investigate the development of fundamental movement skills (FMS) in children with ASD and compare them to typically developing children.MethodThe study recruited 108 children with ASD (87 boys, 21 girls) aged 7–10 years from two special education rehabilitation centers in Wuhan, China. For comparison, a control group of 108 typically developing children, matched by age and gender, was randomly selected from three local primary schools. FMS were assessed using the Movement Assessment Battery for Children - Second Edition (MABC-2), which evaluates manual dexterity, aiming and catching, as well as static and dynamic balance. Group differences on MABC-2 percentile scores were analyzed using descriptive statistics and Mann–Whitney U test. Effect sizes were also calculated for practical significance.ResultsFindings from the study showed that a significant majority, around 80%, of children with ASD either displayed motor challenges or were at risk of developing such delays. When comparing to their typically developing peers, children with ASD scored notably lower in areas of manual dexterity, ball skills, and both static and dynamic balance (with all these findings being statistically significant at p &lt; 0.001). Interestingly, gender did not show a significant influence on these results (p &gt; 0.05).ConclusionIn addition to addressing the other skill development areas outlined in the diagnostic manual for ASD, clinicians diagnosing and treating children with ASD should also assess the presence of motor skill development. For individuals with ASD who have co-existing motor difficulties, it is essential to offer evidence-based interventions tailored to their specific needs.
Interventions addressing the impostor phenomenon: a scoping review
Authors: Para Emma , Dubreuil Philippe , Miquelon Paule , Martin-Krumm Charles 
Published: March 2024

IntroductionThe Impostor Phenomenon (IP) refers to a psychological experience characterized by unjustified feelings of intellectual and professional fraud, accompanied by the fear of not maintaining performance and of being exposed. IP is receiving increasing attention in the fields of psychological health at work and occupational psychology as well as among the general public, since it affects the functioning of both individuals and organizations. The aim of this scoping review is to map the range of interventions that have been conducted to address IP among individuals experiencing it in a professional context.MethodsThe search and selection process to identify relevant reports was conducted using the PRISMA-ScR methodology and JBI recommendations and resulted in the selection of 31 studies.ResultsThe results reported concerning the characteristics of the studies, the interventions described, and the effects identified are heterogeneous. More than half of the studies used research designs (experimental, pre-experimental, exploratory, etc.). Two major types of intervention emerge: training and counseling. The effectiveness of the interventions varies according to the evaluation methodology that was used, although most authors conclude that the proposed intervention is relevant.DiscussionIn light of these results, recognizing and educating individuals regarding the various manifestations of IP, as well as offering support in a group context, appear to be primary intervention levers. Future intervention proposals should explore psychosocial and educational influences as well as the impact of the immediate environment on IP-related beliefs.
Cecropin AD reduces viral load and inflammatory response against H9N2 avian influenza virus in chickens
Authors: Zhang Taiming , Liu Zhenyi , Zhi Yan , Zhao Xinping , Du Mengze , Zhang Qian , Zhang Tao , Hu Ge 
Published: March 2024

IntroductionThis study focuses on evaluating the therapeutic efficacy of cecropin AD, an antimicrobial peptide, against H9N2 avian influenza virus (AIV) in chickens. Given the global impact of H9N2 AIV on poultry health, identifying effective treatments is crucial.MethodsTo assess the impact of cecropin AD, we conducted in vivo experiments involving 108 5-week-old chickens divided into control, infected, and various treatment groups based on cecropin AD dosage levels (high, medium, and low). The methodologies included hemagglutination (HA) tests for viral titers, histopathological examination and toluidine blue (TB) staining for lung pathology, real-time PCR for viral detection, and enzyme-linked immunosorbent assays for measuring serum levels of inflammatory markers.ResultsThe findings revealed that cecropin AD substantially reduced lung pathology and viral load, especially at higher dosages, comparing favorably with the effects seen from conventional treatments. Moreover, cecropin AD effectively modulated mast cell activity and the levels of inflammatory markers such as IL-6, TNF-α, IFN-γ, and 5-HT, indicating its potential to diminish inflammation and viral spread.DiscussionCecropin AD presents a significant potential as an alternative treatment for H9N2 AIV in chickens, as evidenced by its ability to lessen lung damage, decrease viral presence, and adjust immune responses. This positions cecropin AD as a promising candidate for further exploration in the management of H9N2 AIV infections in poultry.
Integrated PSInSAR and GNSS for 3D Displacement in the Wudongde Area
Authors: Huang Jiaxuan , Du Weichao , Jin Shaoxia , Xie Mowen 
Published: March 2024

The major limitation of persistent scatterer interferometric synthetic aperture radar (PSInSAR) is that it detects only one- or two-dimensional displacements, such as those in the line of sight (LOS) and azimuth directions, by repeat-pass SAR observations. Three-dimensional (3D) displacement reflects the actual sliding surface and failure mechanism of a slope. To transform LOS deformation into a reliable 3D displacement, a new approach for obtaining the 3D displacement is proposed herein based on the slope deformation (Dslope). First, the deformation value calculated using the Global Navigation Satellite System (GNSS) as a constraint is used to eliminate the residual deformation of PSInSAR. Then, Dslope is obtained from the relationship between DLOS and the slope angle extracted from the digital elevation model (DEM). Finally, according to the geometric relationship between Dslope and DLOS, a novel approach for calculating 3D displacement is proposed. When comparing the 3D displacement extracted by the proposed method and that from GNSS data in Jinpingzi landslide, the root-mean-square error (RMSE) values were ±2.0 mm, ±2.8 mm, and ±2.6 mm in the vertical, north, and east directions, respectively. The proposed method shows high accuracy in 3D displacement calculation, which can help to determine the failure mechanism of a landslide. This method can be widely used in landslide monitoring in wide areas.
ANALISIS SEMIOTIKA CHARLES SANDERS PEIRCE PADA SIMBOL RAMBU LALU LINTAS DEAD END
Authors: Aryani Saleha , Yuwita Mia Rahmawati 
Published: March 2024

Penelitian ini berjudul Analisis Semiotika Pada Simbol Rambu Lalu Lintas Dead End. Penelitian ini bertujuan untuk mengetahui makna semiotik pada simbol lalu lintas yang bertulisan Dead End atau jalan buntu berdasarkan makna pada warna, bentuk dan juga makna yang direpresentasikan dari kata Dead End itu sendiri dengan menggunakan teori Charles Sanders Peirce. Metode yang digunakan pada penelitian ini adalah metode deskriptif kualitatif karena secara keseluruhan menjelaskan bagaimana proses pembentukan tanda dan pemaknaan tanda tersebut dengan melalui pendekatan semantik. Hasil penelitian ini menunjukan bahwa warna, bentuk dan juga penamaan pada sebuah simbol merupakan hal yang yang sudah ditetapkan dan dihasilkan dari setiap persfektif manusia berdasarkan kenyataannya. Berdasarkan penelitian ini dapat disimpulkan bahwa setiap symbol yang terbentuk berdasarkan warna, bentuk dan juga sebuah kata memiliki makna sesuai dengan persfektif setiap orang.
Kata kunci: Semiotika, Semantik, Simbol, Dead End.
COMPOUND WORD IN INTERNET DATING TERMS
Authors: Habibah Husnun , Tawami Tatan 
Published: March 2024

In this study the authors analyzed the Compound Word in Internet Dating Terms. The author focuses on analyzing the merge of words from existing words to rise the new words/meanings or can also be referred as compounding. The data taken by the author are the words that exist in the term of internet dating by taking examples from cases in social media, namely Twitter. Examples of data cases taken by the author are calculated from March 31, 2020 - March 31, 2022. The method used in this study is descriptive analysis. According to Rakhmat (68), descriptive research method is a research method that only describes situations/events but also explain the data systematically. In researching the selected data, the writer classified the data based on the elements that make up words/expressions on internet dating by focusing on Endocentric and Exocentric Compound. From the analysis, it can be concluded that compound words in internet dating terms were formed mostly by free morphemes, most compound words were not compositional. This means that most compound words are exocentric.
Keywords: Compounding, Exocentric, Endocentric, Internet dating
Pergeseran Akibat Perbedaan Sudut Pandang Budaya dalam Terjemahan Novel Tenki No Ko Karya Makoto Shinkai
Authors: Perdana Muhammad Raka , Ali Mohammad 
Published: March 2024

Tujuan dari penelitian ini adalah untuk mendeskripsikan pergeseran penerjemahan akibat perbedaan sudut pandang budaya pada terjemahan novel tenki no ko yang meliputi sudut pandang budaya secara ekologi, material, sosial kultur, sosial budaya, dan gestur dan adat istiadat. Penelitian ini dilatarbelakangi kurangnya kesepadanan penerjemahan dari Kalimat atau kata bahasa Jepang ke bahasa indonesia dari sudut pandang budaya masing-masing bahasa. Metode yang digunakan adalah deskriptif komparatif dengan pendekatan Kualitatif. Sumber data dari penelitian ini adalah Novel terbitan bahasa jepang berjudul Tenki no ko yang terbit pada tahun 2019, dan terjemahan nya berjudul wheatering with you yang terbit di indonesia pada tahun 2021. Peneliti menemukan 260 data dalam sumber data pergeseran unsur sosial budaya, dari 260 kata yang dianalisis, pada pergeseran unsur budaya Ekologi ditemukan 15 data (6%), pada pergeseran unsur budaya Material Kultur ditemukan 46 data (18%), pada pergeseran unsur budaya Sosial Kultur ditemukan 101 data (39%), pada pergeseran unsur budaya Sosial Organitation ditemukan 12 data (5%), kemudian pada pergeseran unsur budaya Gestur dan adat istiadat ditemukan 86 data (33%). Novel ini dipilih berdasarkan kentalnya unsur budaya dan kehudupan yang tidak jauh berbeda dengan realitas kehidupan di Jepang. Hasil Penelitian ini diharapkan dapat berkontribusi untuk mempelajari bahasa Jepang, khususnya dalam kaitannya dengan pemahaman dalam Strategi penerjemahan dari sudut pandang budaya.
Kata kunci: Penerjemahan, Sudut Pandang Budaya, Tenki no Ko, Wheatering with you
Conceptual Metaphor in SZA's Song Lyrics
Authors: Nugraheny Amanina , Yuwita Mia Rahmawati 
Published: March 2024

The purpose of this study is to examine how conceptual metaphors are used by SZA in her song lyrics. Finding the source domain and target domain of the conceptual metaphors used in song lyrics is the main goal of this study. A descriptive qualitative research approach is used, which includes semantic analysis and conceptual metaphor mapping in song lyrics. The information used consists of five well-known SZA songs that were specifically chosen. The author defines conceptual metaphors in 5 lyrics from SZA's song. In the “Kill Bill” song there is 1 conceptual metaphor, in the “Snooze” song there are 2 conceptual metaphors, in the “The Weekend” song there 3 conceptual metaphors, in the “Nobody Gets Me” song there are 4 conceptual metaphors, and in the “Open Arms” song there is 1 conceptual metaphor. The research provides our understanding of how conceptual metaphor is used in song lyrics and shows the depth of creativity and artistic expression found in SZA's songs. The findings of this study may be helpful for future semantics and cultural studies research, as well as for developing a deeper understanding of both the complexity and the beauty of SZA's song lyrics.
Keywords: Conceptual metaphor, Lyrics, Songs, Semantics