bluuebunny/crossref_metadata_2025_split huggingface dataset:
Regulation of the Cell Cycle by Protein Phosphatase 2A in
Saccharomyces cerevisiae
Authors: Jiang Yu 
Published: June 2006

SUMMARY

Protein phosphatase 2A (PP2A) has long been implicated in cell cycle regulation in many different organisms. In the yeast
Saccharomyces cerevisiae
, PP2A controls cell cycle progression mainly through modulation of cyclin-dependent kinase (CDK) at the G
2
/M transition. However, CDK does not appear to be a direct target of PP2A. PP2A affects CDK activity through its roles in checkpoint controls. Inactivation of PP2A downregulates CDK by activating the morphogenesis checkpoint and, consequently, delays mitotic entry. Defects in PP2A also compromise the spindle checkpoint and predispose the cell to an error-prone mitotic exit. In addition, PP2A is involved in controlling the G
1
/S transition and cytokinesis. These findings suggest that PP2A functions in many stages of the cell cycle and its effect on cell cycle progression is pleiotropic.
Exposure to non-arsenic pesticides is associated with lymphoma among farmers in Spain
Authors: van Balen E , Font R , Cavallé N , Font L , Garcia-Villanueva M , Benavente Y , Brennan P , de Sanjose S 
Published: June 2006

Objectives:To estimate the risk of lymphoma among farmers in Spain.Methods:This is a multicentre case control study conducted in Spain. Cases were subjects diagnosed with lymphoma according to the World Health Organization (WHO) classification in four hospitals between 1998–2002. Hospital controls were frequency matched to the cases by sex, age, and centre. All subjects were interviewed about jobs ever held in lifetime for at least one year and the exposures in those jobs were recorded. The risk of lymphomas among subjects ever having had a job as a farmer was compared with all other occupations. Farmers were analysed according to the type of farming job performed: crop farming, animal farming, and general farming. Occupational exposure was summarised into 15 main categories: organic dust, radiation, contact with animals, PAH, non-arsenic pesticides (carbamates, organophosphates, chlorinated hydrocarbons, triazines and triazoles, phenoxy herbicides, chlorophenols, dibenzodioxin, and dibenzofuran), arsenic pesticides, contact with meat, contact with children, solvents, asbestos, soldering fumes, organic colourants, polychlorinated biphenyls, ethylene oxide, and hair dyes.Results:Although farmers were not at an increased risk of lymphoma as compared with all other occupations, farmers exposed to non-arsenic pesticides were found to be at increased risk of lymphoma (OR = 1.8, 95% CI 1.1 to 2). This increased risk was observed among farmers working exclusively either as crop farmers or as animal farmers (OR = 2.8, 95% CI 1.3 to 5.8). Risk was highest for exposure to non-arsenic pesticides for over nine years (OR = 2.4, 95% CI 1.2 to 2.8).Conclusions:Long term exposure to non-arsenic pesticides may induce lymphomagenesis among farmers.
Wheezing, asthma, hay fever, and atopic eczema in relation to maternal occupations in pregnancy
Authors: Magnusson L L , Wennborg H , Bonde J P , Olsen J 
Published: June 2006

Objectives:To examine whether prenatal occupational exposures, especially to organic solvents, are associated with atopic diseases in childhood.Methods:The study comprised children born in Odense or Aalborg, Denmark between 1984 and 1987. Occupational job titles were derived from questionnaires filled out by the mothers when attending midwife centres. Assessment of organic solvent exposures was based on job titles selected by occupational specialists. A follow up questionnaire to the parents provided data on medical diagnoses as well as wheezing symptoms for 7844 children aged 14–18. Multivariate logistic regression analyses were performed to estimate the cumulative risk for wheezing (early wheezing not diagnosed as asthma), asthma, hay fever, and atopic eczema during childhood by means of odds ratios (OR) and 95% confidence intervals (CI).Results:Explorative analyses by maternal job titles in pregnancy showed elevated odds ratios concerning different atopic diseases for occupational groups such as “bakers, pastry cooks, and confectionary makers”, “dental assistants”, “electrical and electronic assemblers”, “sewers and embroiders”, and “bookbinders and related workers”. An excess risk ratio for hay fever (OR 2.8, CI 1.1 to 7.5) was found following maternal gestational exposure to organic solvents. Furthermore, a slightly raised odds ratio for asthma was observed in children of shift workers (OR 1.2, CI 1.0 to 1.5).Conclusion:The data suggest links between certain maternal occupations during pregnancy and atopic diseases, which merits further scrutiny. However, no consistent pattern was seen across the different atopic diseases.
Delta-aminolevulinic acid dehydratase polymorphism and the relation between low level lead exposure and the Mini-Mental Status Examination in older men: the Normative Aging Study
Authors: Weuve J , Kelsey K T , Schwartz J , Bellinger D , Wright R O , Rajan P , Spiro A , Sparrow D , Aro A , Hu H 
Published: June 2006

Objective:To determine whether a polymorphism the in δ-aminolevulinic acid dehydratase (ALAD) gene modifies the neurotoxicity of lead in older adults.Methods:The authors studied men participating in the Department of Veterans Affairs’ Normative Aging Study, assessing their recent exposure to lead by measuring blood lead (n = 915) at each triennial clinic visit, and, beginning in 1991, assessing their cumulative exposure by measuring lead levels in tibia (n = 722) and patella (n = 720), using K-shellxray fluorescence. Starting in 1993 and again at each triennial visit, the authors administered the Mini-Mental State Examination (MMSE) to assess their cognitive functioning. The relation of the lead biomarkers to MMSE score was evaluated and this association was compared among men who carried the variant allele,ALAD-2, versus men without the allele.Results:Sixteen per cent of men carried theALAD-2allele. Median tibia and patella lead levels (first-third quartile) were 19 (13–28) and 27 (18–39) μg/g. Blood lead levels were consistent with non-occupational exposure: only 6% of men had levels ⩾10 μg/dl. In multivariable adjusted analyses, higher levels of blood lead were associated with poorer performance on the MMSE. This association was most pronounced amongALAD-2carriers, among whom a 3 μg/dl increment in blood lead (the interquartile range) was associated with a 0.26 point lower mean MMSE score (95% CI −0.54 to 0.01), compared with a 0.04 point lower score (95% CI −0.16 to 0.07) among non-carriers. The modest 0.22 point difference in these associations did not attain statistical significance, however (pinteraction = 0.13). The associations between bone lead levels and MMSE score did not vary byALAD-2status.Conclusions:Although not statistically significant, these findings suggest thatALADgenotype may modify blood lead’s adverse association with cognition among older men who had community exposures to lead. However, despite a relatively large sample size and the use of sensitive methods for measuring lead burden, the evidence overall was fairly weak.
Diurnal Coupling in the Tropical Oceans of CCSM3
Authors: Danabasoglu Gokhan , Large William G. , Tribbia Joseph J. , Gent Peter R. , Briegleb Bruce P. , McWilliams James C. 
Published: June 2006

Abstract
New features that may affect the behavior of the upper ocean in the Community Climate System Model version 3 (CCSM3) are described. In particular, the addition of an idealized diurnal cycle of solar forcing where the daily mean solar radiation received in each daily coupling interval is distributed over 12 daylight hours is evaluated. The motivation for this simple diurnal cycle is to improve the behavior of the upper ocean, relative to the constant forcing over each day of previous CCSM versions. Both 1- and 3-h coupling intervals are also considered as possible alternatives that explicitly resolve the diurnal cycle of solar forcing. The most prominent and robust effects of all these diurnal cycles are found in the tropical oceans, especially in the Pacific. Here, the mean equatorial sea surface temperature (SST) is warmed by as much as 1°C, in better agreement with observations, and the mean boundary layer depth is reduced. Simple rectification of the diurnal cycle explains about half of the shallowing, but less than 0.1°C of the warming. The atmospheric response to prescribed warm SST anomalies of about 1°C displays a very different heat flux signature. The implication, yet to be verified, is that large-scale air–sea coupling is a prime mechanism for amplifying the rectified, daily averaged SST signals seen by the atmosphere. Although the use of upper-layer temperature for SST in CCSM3 underestimates the diurnal cycle of SST, many of the essential characteristics of diurnal cycling within the equatorial ocean are reproduced, including boundary layer depth, currents, and the parameterized vertical heat and momentum fluxes associated with deep-cycle turbulence. The conclusion is that the implementation of an idealized diurnal cycle of solar forcing may make more frequent ocean coupling and its computational complications unnecessary as improvements to the air–sea coupling in CCSM3 continue. A caveat here is that more frequent ocean coupling tends to reduce the long-term cooling trends typical of CCSM3 by heating already too warm ocean depths, but longer integrations are needed to determine robust features. A clear result is that the absence of diurnal solar forcing of the ocean has several undesirable consequences in CCSM3, including too large ENSO variability, much too cold Pacific equatorial SST, and no deep-cycle turbulence.
The Community Land Model and Its Climate Statistics as a Component of the Community Climate System Model
Authors: Dickinson Robert E. , Oleson Keith W. , Bonan Gordon , Hoffman Forrest , Thornton Peter , Vertenstein Mariana , Yang Zong-Liang , Zeng Xubin 
Published: June 2006

Abstract
Several multidecadal simulations have been carried out with the new version of the Community Climate System Model (CCSM). This paper reports an analysis of the land component of these simulations. Global annual averages over land appear to be within the uncertainty of observational datasets, but the seasonal cycle over land of temperature and precipitation appears to be too weak. These departures from observations appear to be primarily a consequence of deficiencies in the simulation of the atmospheric model rather than of the land processes. High latitudes of northern winter are biased sufficiently warm to have a significant impact on the simulated value of global land temperature. The precipitation is approximately doubled from what it should be at some locations, and the snowpack and spring runoff are also excessive. The winter precipitation over Tibet is larger than observed. About two-thirds of this precipitation is sublimated during the winter, but what remains still produces a snowpack that is very large compared to that observed with correspondingly excessive spring runoff. A large cold anomaly over the Sahara Desert and Sahel also appears to be a consequence of a large anomaly in downward longwave radiation; low column water vapor appears to be most responsible. The modeled precipitation over the Amazon basin is low compared to that observed, the soil becomes too dry, and the temperature is too warm during the dry season.
Last Glacial Maximum and Holocene Climate in CCSM3
Authors: Otto-Bliesner Bette L. , Brady Esther C. , Clauzet Gabriel , Tomas Robert , Levis Samuel , Kothavala Zav 
Published: June 2006

Abstract
The climate sensitivity of the Community Climate System Model version 3 (CCSM3) is studied for two past climate forcings, the Last Glacial Maximum (LGM) and the mid-Holocene. The LGM, approximately 21 000 yr ago, is a glacial period with large changes in the greenhouse gases, sea level, and ice sheets. The mid-Holocene, approximately 6000 yr ago, occurred during the current interglacial with primary changes in the seasonal solar irradiance.
The LGM CCSM3 simulation has a global cooling of 4.5°C compared to preindustrial (PI) conditions with amplification of this cooling at high latitudes and over the continental ice sheets present at LGM. Tropical sea surface temperature (SST) cools by 1.7°C and tropical land temperature cools by 2.6°C on average. Simulations with the CCSM3 slab ocean model suggest that about half of the global cooling is explained by the reduced LGM concentration of atmospheric CO2 (∼50% of present-day concentrations). There is an increase in the Antarctic Circumpolar Current and Antarctic Bottom Water formation, and with increased ocean stratification, somewhat weaker and much shallower North Atlantic Deep Water. The mid-Holocene CCSM3 simulation has a global, annual cooling of less than 0.1°C compared to the PI simulation. Much larger and significant changes occur regionally and seasonally, including a more intense northern African summer monsoon, reduced Arctic sea ice in all months, and weaker ENSO variability.
Representation of Clouds and Precipitation Processes in the Community Atmosphere Model Version 3 (CAM3)
Authors: Boville Byron A. , Rasch Philip J. , Hack James J. , McCaa James R. 
Published: June 2006

Abstract
The parameterizations of clouds and precipitation processes have been revised considerably in the Community Atmosphere Model version 3 (CAM3) compared to its predecessors, CAM2 and the Community Climate Model version 3 (CCM3). The parameterizations in CAM3 are more realistic in their representation of processes affecting cloud liquid and ice particles and represent the linkages between processes more completely. This paper describes the changes to the representation of clouds in CAM3, including the partitioning of cloud water between liquid and ice phases, the determination of particle sizes and sedimentation rates, the phase and evaporation rate of precipitation, and the calculation of the cloud fraction.
Parameterization changes between CCM3 and CAM2 introduced a significant cold bias at the tropical tropopause, resulting in a dry bias for stratospheric water vapor. Tests of the sensitivity of the tropical temperature profile and the tropical tropopause temperature to individual process changes suggested that the radiative balance at the tropopause was altered by improvements in both clouds and relative humidity below. Radiative equilibrium calculations suggested that the cold bias could be removed by improving the representation of subvisible cirrus clouds. These results motivated the complete separation of the representation of liquid and ice cloud particles and an examination of the processes that determine their sources and sinks. As a result of these changes, the tropopause cold bias has been almost eliminated in CAM3.
The total cloud condensate variable, used in CAM2, has been separated into cloud liquid and cloud ice variables in CAM3. Both sedimentation and large-scale transport of the condensate variables are now included. Snowfall is computed explicitly and the latent heat of fusion has been included for all freezing and melting processes. Both deep and shallow convection parameterizations now detrain cloud condensate directly into the stratiform clouds instead of evaporating the detrained condensate into the environment. The convective parameterizations are not easily modified to include the latent heat of fusion. Therefore, the determination of the phase of convective precipitation, and of detrained condensate, is added as a separate step. Evaporation is included for sedimenting cloud particles and for all sources of precipitation.
Simulation of the Global Hydrological Cycle in the CCSM Community Atmosphere Model Version 3 (CAM3): Mean Features
Authors: Hack James J. , Caron Julie M. , Yeager Stephen G. , Oleson Keith W. , Holland Marika M. , Truesdale John E. , Rasch Philip J. 
Published: June 2006

Abstract
The seasonal and annual climatological behavior of selected components of the hydrological cycle are presented from coupled and uncoupled configurations of the atmospheric component of the Community Climate System Model (CCSM) Community Atmosphere Model version 3 (CAM3). The formulations of processes that play a role in the hydrological cycle are significantly more complex when compared with earlier versions of the atmospheric model. Major features of the simulated hydrological cycle are compared against available observational data, and the strengths and weaknesses are discussed in the context of specified sea surface temperature and fully coupled model simulations.
The magnitude of the CAM3 hydrological cycle is weaker than in earlier versions of the model, and is more consistent with observational estimates. Major features of the exchange of water with the surface, and the vertically integrated storage of water in the atmosphere, are generally well captured on seasonal and longer time scales. The water cycle response to ENSO events is also very realistic. The simulation, however, continues to exhibit a number of long-standing biases, such as a tendency to produce double ITCZ-like structures in the deep Tropics, and to overestimate precipitation rates poleward of the extratropical storm tracks. The lower-tropospheric dry bias, associated with the parameterized treatment of convection, also remains a simulation deficiency. Several of these biases are exacerbated when the atmosphere is coupled to fully interactive surface models, although the larger-scale behavior of the hydrological cycle remains nearly identical to simulations with prescribed distributions of sea surface temperature and sea ice.
The Influence of Sea Ice on Ocean Heat Uptake in Response to Increasing CO2
Authors: Bitz C. M. , Gent P. R. , Woodgate R. A. , Holland M. M. , Lindsay R. 
Published: June 2006

Abstract
Two significant changes in ocean heat uptake that occur in the vicinity of sea ice cover in response to increasing CO2 are investigated with Community Climate System Model version 3 (CCSM3): a deep warming below ∼500 m and extending down several kilometers in the Southern Ocean and warming in a ∼200-m layer just below the surface in the Arctic Ocean. Ocean heat uptake caused by sea ice retreat is isolated by running the model with the sea ice albedo reduced artificially alone. This integration has a climate response with strong ocean heat uptake in the Southern Ocean and modest ocean heat uptake in the subsurface Arctic Ocean.
The Arctic Ocean warming results from enhanced ocean heat transport from the northern North Atlantic. At the time of CO2 doubling, about 1/3 of the heat transport anomaly results from advection of anomalously warm water and 2/3 results from strengthened inflow. At the same time the overturning circulation is strengthened in the northern North Atlantic and Arctic Oceans. Wind stress changes cannot explain the circulation changes, which instead appear related to strengthened convection along the Siberian shelves.
Deep ocean warming in the Southern Ocean is initiated by weakened convection, which is mainly a result of surface freshening through altered sea ice and ocean freshwater transport. Below about 500 m, changes in convection reduce the vertical and meridional temperature gradients in the Southern Ocean, which significantly reduce isopycnal diffusion of heat upward around Antarctica. The geometry of the sea ice cover and its influence on convection have a strong influence on ocean temperature gradients, making sea ice an important player in deep ocean heat uptake in the Southern Ocean.
Involvement of various hematopoietic-cell lineages by the JAK2V617F mutation in polycythemia vera
Authors: Ishii Takefumi , Bruno Edward , Hoffman Ronald , Xu Mingjiang 
Published: June 2006

AbstractThe JAK2V617F mutation has been shown to occur in the overwhelming majority of patients with polycythemia vera (PV). To study the role of the mutation in the excessive production of differentiated hematopoietic cells in PV, CD19+, CD3+, CD34+, CD33+, and glycophorin A+ cells and granulocytes were isolated from the peripheral blood (PB) of 8 patients with PV and 3 healthy donors mobilized with G-CSF, and the percentage of JAK2V617F mutant allele was determined by quantitative real-time polymerase chain reaction (PCR). The JAK2V617F mutation was present in cells belonging to each of the myeloid lineages and was also present in B and T lymphocytes in a subpopulation of patients with PV. The proportion of hematopoietic cells expressing the JAK2V617F mutation decreased after differentiation of CD34+ cells in vitro in the presence of optimal concentrations of SCF, IL-3, IL-6, and Epo. These data suggest that the JAK2V617F mutation may not provide a proliferative and/or survival advantage for the abnormal PV clone. Although the JAK2V617F mutation plays an important role in the biologic origins of PV, it is likely not the sole event leading to PV.
Falls and consequent injuries in hospitalized patients: effects of an interdisciplinary falls prevention program
Authors: Schwendimann René , Bühler Hugo , De Geest Sabina , Milisen Koen 
Published: June 2006

Abstract
Background
Patient falls in hospitals are common and may lead to negative outcomes such as injuries, prolonged hospitalization and legal liability. Consequently, various hospital falls prevention programs have been implemented in the last decades. However, most of the programs had no sustained effects on falls reduction over extended periods of time.

Methods
This study used a serial survey design to examine in-patient fall rates and consequent injuries before and after the implementation of an interdisciplinary falls prevention program (IFP) in a 300-bed urban public hospital. The population under study included adult patients, hospitalized in the departments of internal medicine, geriatrics, and surgery. Administrative patient data and fall incident report data from 1999 to 2003 were examined and summarized using frequencies, proportions, means and standard deviations and were analyzed accordingly.

Results
A total of 34,972 hospitalized patients (mean age: 67.3, SD ± 19.3 years; female 53.6%, mean length of stay: 11.9 ± 13.2 days, mean nursing care time per day: 3.5 ± 1.4 hours) were observed during the study period. Overall, a total of 3,842 falls affected 2,512 (7.2%) of the hospitalized patients. From these falls, 2,552 (66.4%) were without injuries, while 1,142 (29.7%) falls resulted in minor injuries, and 148 (3.9%) falls resulted in major injuries. The overall fall rate in the hospitals' patient population was 8.9 falls per 1,000 patient days. The fall rates fluctuated slightly from 9.1 falls in 1999 to 8.6 falls in 2003. After the implementation of the IFP, in 2001 a slight decrease to 7.8 falls per 1,000 patient days was observed (p = 0.086). The annual proportion of minor and major injuries did not decrease after the implementation of the IFP. From 1999 to 2003, patient characteristics changed in terms of slight increases (female gender, age, consumed nursing care time) or decreases (length of hospital stay), as well as the prevalence of fall risk factors increased up to 46.8% in those patients who fell.

Conclusion
Following the implementation of an interdisciplinary falls prevention program, neither the frequencies of falls nor consequent injuries decreased substantially. Future studies need to incorporate strategies to maximize and evaluate ongoing adherence to interventions in hospital falls prevention programs.