bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fitness age outperforms body mass index in differentiating aging patterns and health risk profiles of healthy adults aged 51–80 years
Authors: A. Manca , L. Ventura , G. Martinez , M. Morrone , A. Boi , G. Fiorito , B. Mercante , A. Cano , G. Catte M. , S. Cruciani , C. Pozzati , A. Uccula , F. Ginatempo , M. Maioli , P. Delitala A. , G. Solinas , A. Zinellu , C. Carru , F. Deriu 
Published: March 2024

AbstractPhysical fitness has been extensively shown to strongly associate with general health status and major health risks. Here we tested the ability of a novel estimate of fitness age (FitAge) to differentiate aging trajectories.This study aimed at (1) testing the ability of FitAge to differentiate aging patterns among decelerated, normal, and accelerated agers in selected health domains, (2) estimating the risk for developing major health issues depending on the aging trajectory, and (3) comparing FitAge to body mass index (BMI) categorization in differentiating healthy from unhealthy aging patterns.A total of 176 volunteers participated in this cross-sectional study. Participants underwent clinical screening and a comprehensive assessment of body composition, nutritional and health-related status, cognitive functioning, and haematochemical analyses with routine tests, oxidative stress, and inflammation markers. Scores for major health risks were also computed.FitAge outperformed BMI in estimating major health risk scores and was able to differentiate decelerated from normal and accelerated agers for health risk profile and several physiological domains. Body composition, immune system activation, and inflammation markers emerged as those variables flagging the largest differences between decelerated and accelerated aging patterns.The novel estimate of biological aging can accurately differentiate both in women and men decelerated from accelerated agers in almost all the domains scrutinized. Overall, decelerated aging is linked to positively oriented features which associate with reduced risk of developing major health issues.The present findings have potential relevance and practical implications to identify individuals at higher risk of accelerated aging according to their FitAge estimated via simple and cost-effective motor tests.
Association Between Self-Reported Opioid Use and Behavioral/Social Health Characteristics—Arizona, 2020
Authors: Davidson Samantha , Javadi Mercedeh , Gallaway M. Shayne 
Published: March 2024

Abstract
Background
Arizona observed a sharp increase in opioid overdose deaths between 2017 and 2021. Our objective was to better understand the relationship between behavioral/ social characteristics and self-reported opioid misuse among Arizona adults.

Methods
A cross-sectional study design was done using data from the Arizona 2020 Behavioral Risk Factor Surveillance System (BRFSS) (N = 10,291). Confidence intervals and p-values were found using chi-square for respondents with and without a self-reported opioid misuse. Logistic regression models were developed for the association between adverse childhood experiences (ACEs), mental health, and risk-taking behaviors (RTBs) and opioid misuse.

Results
Respondents who reported 2–3 ACEs (ORadjusted: 4.7; 95% CI: [2.8, 7.9]) and who reported 4 or more ACEs (ORadjusted: 8.3; 95% CI: [5.0, 13.6]); respondents who reported poor mental health (ORadjusted: 3.3; 95% CI: [2.1, 5.2]); and respondents who reported two or more RTBs (ORadjusted: 3.9; 95% CI: [2.5, 6.1]) had higher odds of self-reported opioid misuse compared to those without self-reported opioid misuse.

Discussion
Opioid misuse was found to be associated with poor mental and physical health, increased RTBs, and history of at least two ACEs among Arizona adults in this study. These findings stress the importance of opportunities for targeted prevention in both Arizona adults and youth, including screening for ACEs and RTBs, in early stages of life.
Socioeconomic Inequalities in SARS-CoV-2 Infection and COVID-19 Health Outcomes in Urban Italy During the COVID-19 Vaccine Rollout, January–November 2021
Authors: Fotakis Emmanouil Alexandros , Mateo-Urdiales Alberto , Fabiani Massimo , Sacco Chiara , Petrone Daniele , Riccardo Flavia , Bella Antonino , Pezzotti Patrizio 
Published: March 2024

AbstractThis study analysed the evolution of the association of socioeconomic deprivation (SED) with SARS-CoV-2 infection and COVID-19 outcomes in urban Italy during the vaccine rollout in 2021. We conducted a retrospective cohort analysis between January and November 2021, comprising of 16,044,530 individuals aged ≥ 20 years, by linking national COVID-19 surveillance system data to the Italian SED index calculated at census block level. We estimated incidence rate ratios (IRRs) of infection and severe COVID-19 outcomes by SED tercile relative to the least deprived tercile, over three periods defined as low (0–10%); intermediate (> 10–60%) and high (> 60–74%) vaccination coverage. We found patterns of increasing relative socioeconomic inequalities in infection, hospitalisation and death as COVID-19 vaccination coverage increased. Between the low and high coverage periods, IRRs for the most deprived areas increased from 1.09 (95%CI 1.03–1.15) to 1.28 (95%CI 1.21–1.37) for infection; 1.48 (95%CI 1.36–1.61) to 2.02 (95%CI 1.82–2.25) for hospitalisation and 1.57 (95%CI 1.36–1.80) to 1.89 (95%CI 1.53–2.34) for death. Deprived populations in urban Italy should be considered as vulnerable groups in future pandemic preparedness plans to respond to COVID-19 in particular during mass vaccination roll out phases with gradual lifting of social distancing measures.
Modeling of Mouse Experiments Suggests that Optimal Anti-Hormonal Treatment for Breast Cancer is Diet-Dependent
Authors: Akman Tuğba , Arendt Lisa M. , Geisler Jürgen , Kristensen Vessela N. , Frigessi Arnoldo , Köhn-Luque Alvaro 
Published: March 2024

AbstractEstrogen receptor positive breast cancer is frequently treated with anti-hormonal treatment such as aromatase inhibitors (AI). Interestingly, a high body mass index has been shown to have a negative impact on AI efficacy, most likely due to disturbances in steroid metabolism and adipokine production. Here, we propose a mathematical model based on a system of ordinary differential equations to investigate the effect of high-fat diet on tumor growth. We inform the model with data from mouse experiments, where the animals are fed with high-fat or control (normal) diet. By incorporating AI treatment with drug resistance into the model and by solving optimal control problems we found differential responses for control and high-fat diet. To the best of our knowledge, this is the first attempt to model optimal anti-hormonal treatment for breast cancer in the presence of drug resistance. Our results underline the importance of considering high-fat diet and obesity as factors influencing clinical outcomes during anti-hormonal therapies in breast cancer patients.
Drivers for Inter-city Innovation Networks Across Chinese Cities: Modelling Physical Versus Intangible Effects
Authors: Gao Yujie , Scherngell Thomas , Neuländtner Martina 
Published: March 2024

AbstractCross-region innovation is widely recognized as an important source of the long-term regional innovation capacity. In the recent past, a growing number of studies has investigated the network structure and mechanisms of cross-region innovation collaboration in various contexts. However, existing research mainly focuses on physical effects, such as geographical distance and high-speed railway connections. These studies ignore the intangible drivers in a changing environment, the more digitalized economy and the increasingly solidified innovation network structure. Thus, the focus of this study is on estimating determinants of innovation networks, especially on intangible drivers, which have been largely neglected so far. Using city-level data of Chinese patents (excluding Hong Kong, Macao, and Taiwan Province of China), we trace innovation networks across Chinese cities over a long period of time. By integrating a measure on Information and Communications Technology (ICT) development gap and network structural effects into the general proximity framework, this paper explores the changing mechanisms of Chinese innovation networks from a new perspective. The results show that the structure of cross-region innovation networks has changed in China. As mechanisms behind this development, the results confirm the increasingly important role of intangible drivers in Chinese inter-city innovation collaboration when controlling for effects of physical proximity, such as geographical distance. Since digitalization and coordinated development are the mainstream trends in China and other developing countries, these countries’ inter-city innovation collaboration patterns will witness dramatic changes under the influence of intangible drivers.
Recovery of Cerium from Automotive Catalytic Converters
Authors: Peer Michael , Fehn Thomas , Hofmann Alexander , Berninger Burkhard , Kunz Werner 
Published: March 2024

AbstractPlatinum group metals (PGM) and cerium as one of the rare-earth elements are considered as critical raw materials, thus their recycling and re-use is of utmost importance. Among the PGMs, platinum (Pt), palladium (Pd), and rhodium (Rh) are the basic and most valuable metals used in catalytic converters. Due to the high price of PGMs, there are already recycling routes in Europe and especially in Germany. For PGM and rare-earth elements, research is focusing on greener, plain recovery techniques, which utilize milder reagents, offer better energy efficiency, and replace the existing recycling routes. In this work, a hydrometallurgical process is proposed to add a hydrometallurgy method to the mostly pyrometallurgical industrial recycling routes, resulting in recovery rates for cerium and PGMs of 63.21% and only 1.03% with sulfuric acid, respectively. With hydrochloric acid, the leaching efficiency for cerium is even lower, and for PGM it is comparable. In the method proposed in the present paper, the main PGMs remain in monoliths and can be recycled in existing recycling routes like pyrometallurgical recycling.
Experiences of Burnout, Post-Traumatic Growth, and Organisational Support in Police Officers Working in Specialised Units: An Interpretative Phenomenological Analysis
Authors: Tsirimokou Alexandra , Kloess Juliane A. , Dhinse Sonia K. , Larkin Michael 
Published: March 2024

AbstractRepeated exposure to traumatogenic material is a part of every working day for police officers in specialist units, such as forensic scene investigation and digital forensic analysis, with recent years marking an increase in its volume and intensity (Office for National Statistics (2018). While this may be considered a price paid for choosing to pursue careers in these areas, it is likely to have a significant impact on a professional and personal level, with psychological and physical effects extending beyond the individual’s working hours (Burns et al. in Traumatology 14:20–31, 2008). On the other hand, this important work may contribute to elements of growth and self-development, recognised in existing literature as post-traumatic growth (Tedschi and Calhoun in SAGE Publications, Inc, 1995). The present study adopted a qualitative approach to understanding the lived experiences of seven digital forensic analysts and two forensic scene investigators. Semi-structured interviews explored the impact of their work, as well as their coping strategies and perceived organisational support. Using interpretative phenomenological analysis (IPA), the study yielded rich personal accounts and identified three superordinate themes: “The effects are inevitable”, “Creating a safe environment”, and “Sense of responsibility and personal growth”. Participants described the inevitable effects of their work, along with their coping strategies developed in response to these. Furthermore, participants considered the safety of their work environment and relationships with their colleagues, while also reflecting on their experience of personal growth through their exposure to adversity. Findings are discussed in relation to theoretical and practical implications, as well as directions for future research.
From Pluripotent Stem Cells to Organoids and Bioprinting: Recent Advances in Dental Epithelium and Ameloblast Models to Study Tooth Biology and Regeneration
Authors: Hermans Florian , Hasevoets Steffie , Vankelecom Hugo , Bronckaers Annelies , Lambrichts Ivo 
Published: March 2024

AbstractAmeloblasts are the specialized dental epithelial cell type responsible for enamel formation. Following completion of enamel development in humans, ameloblasts are lost and biological repair or regeneration of enamel is not possible. In the past, in vitro models to study dental epithelium and ameloblast biology were limited to freshly isolated primary cells or immortalized cell lines, both with limited translational potential. In recent years, large strides have been made with the development of induced pluripotent stem cell and organoid models of this essential dental lineage – both enabling modeling of human dental epithelium. Upon induction with several different signaling factors (such as transforming growth factor and bone morphogenetic proteins) these models display elevated expression of ameloblast markers and enamel matrix proteins. The advent of 3D bioprinting, and its potential combination with these advanced cellular tools, is poised to revolutionize the field – and its potential for tissue engineering, regenerative and personalized medicine. As the advancements in these technologies are rapidly evolving, we evaluate the current state-of-the-art regarding in vitro cell culture models of dental epithelium and ameloblast lineage with a particular focus toward their applicability for translational tissue engineering and regenerative/personalized medicine.
Graphical Abstract
Future perspectives for in vitro modeling of dental epithelium and ameloblasts. Development of iPSC and organoid models that can reliably generate dental epithelium and ameloblast-like cells, together with advances in 3D bioprinting, provide promising tools for enamel research. Advanced models will provide new avenues for development of enamel repair/regeneration approaches, for testing of dental materials or drugs, studying host-pathogen and/or cell-cell interactions, in vitro modeling of enamel diseases (e.g. amelogenesis imperfecta) and developing novel insights in fundamental tooth biology (e.g. regulation of amelogenesis, lineage specification). Abbreviations: iPSC: induced pluripotent stem cells; TO: tooth organoids; DE: dental epithelium; AB: ameloblast.
Early age at menarche and the risk of gestational diabetes mellitus: a cohort study
Authors: Angelopoulou Anastasia , Athanasiadou Kleoniki I. , Zairi Maria , Zapanti Evangelia , Vasileiou Vasiliki , Paschou Stavroula A. , Anastasiou Eleni 
Published: March 2024

Abstract
Purpose
To evaluate whether there is an association between age at menarche (AAM) and the risk of gestational diabetes mellitus (GDM).

Methods
A retrospective cohort study was conducted, including 5390 pregnant women who were screened for GDM at Alexandra Hospital in Athens, Greece over a 15-year period (2000–2014). Maternal age, pre-pregnancy body mass index (BMI), height, family history of type 2 diabetes mellitus, parity, educational and smoking status, and AAM were recorded. The results were expressed as odds ratios (OR) with a 95% confidence interval (95% CI).

Results
Pregnant women with GDM experienced earlier menarche compared to normoglycemic women (12.9 ± 1.5 vs 13.1 ± 1.6, p < 0.001, respectively). The OR for a woman with AAM <12 years to develop GDM was 1.08 (95% CI 1.03–1.14), while the OR to be obese was 1.70 (95% CI 1.50–1.90). The multivariate logistic regression analysis showed that AAM is a risk factor for GDM. However, that effect was lost after adjusting for BMI.

Conclusion
Early AAM may be associated with an increased risk of GDM. Therefore, it can be used to identify high-risk women and implement preconception interventions for GDM prevention. Future studies should be conducted to confirm these findings.
Treatment-changing news in urogenital cancer—a brief unstructured narrative review based on findings presented at the ESMO 2023 conference
Authors: Zgubic Alexander Jakob , Leitsmann Marianne , Ahyai Sascha , Pichler Martin 
Published: March 2024

SummaryThis article gives an overview through the most promising and practise changing studies presented for urothelial cancer at ESMO 2023 conference.
Deoxynivalenol triggers the expression of IL-8-related signaling cascades and decreases protein biosynthesis in primary monocyte-derived cells
Authors: Nossol Constanze , Landgraf P. , Oster M. , Kahlert S. , Barta-Böszörmenyi A. , Kluess J. , Wimmers K. , Isermann B. , Stork O. , Dieterich D. C. , Dänicke S. , Rothkötter H.-J. 
Published: March 2024

AbstractHumans and their immune system are confronted with mold-contaminated food and/or mold-contaminated air in daily life and indoor activities. This results in metabolic stress and unspecific disease symptoms. Other studies provided evidence that exposure to mold is associated with the etiology of allergies. Deoxynivalenol (DON) is of great concern due to its frequent occurrence in toxically relevant concentrations. The exposure to this toxin is a permanent health risk for both humans and farm animals because DON cannot be significantly removed during standard milling and processing procedures. However, the direct effect on immunity or hematology is poorly defined because most investigations could not separate the effect of DON-contaminated feed intake. Due to the widespread distribution of DON after rapid absorption, it is not surprising that DON is known to affect the immune system. The immune system of the organism has one important function, to defend against the invasion of unknown substances/organisms. This study shows for the first time a synergistic effect of both—low physiological DON-doses in combination with low LPS-doses with the focus on the IL-8 expression on protein and RNA level. Both doses were found in vivo. IL-8 together with other anorectic cytokines like IL-1β can affect the food intake and anorexia. We could also show that a calcium-response is not involved in the increased IL-8 production after acute DON stimulation with high or low concentrations.
That was a foul! How viewing angles, viewing distances, and visualization methods influence football referees’ decision-making
Authors: Vater Christian , Schnyder Urs , Müller Daniel 
Published: March 2024

AbstractA football referee must choose the right position on the field in order to perceive a foul accurately. In previous research, decision-making for foul calls was compared across different situations within a match or even across different matches, which questions the comparability of decisions that often depend on the situational context. In this study, we experimentally controlled this situational context to investigate the effect of viewing distance and viewing angle on referees’ decision-making. We recreated real-life decision-making situations using markerless tracking devices and virtual reality (VR) animation processes to render first-person situations. We compared the decision-making accuracy of ten experienced football referees when judging situations from three different viewing angles and distances. Furthermore, we compared their decision-making accuracy in VR scenes with accuracy when viewing the same scenes from a bird’s eye and slow-motion perspective, i.e., with the perspectives used in official referee training. We found that decision accuracy is not affected by viewing angles and distances, but that the referee’s decision certainty is lower when viewing the foul situation from a greater distance. The visualization of the situations had an impact on the referee’s decision-making but only for detecting a simulation (i.e., a player acts like they have been fouled). Slow-motion scenes led to higher decision-making accuracy than VR scenes. Our study suggests a way to recreate VR situations for experimental studies, allowing researchers to control the context of each situation. Our findings help to disentangle the mixed findings of previous studies on distance and viewing angle effects on decision accuracies. Finally, we propose potential avenues to improve VR animation processes in future studies.
Solid pseudopapillary neoplasm (SPN) of the pancreas: current understanding on its malignant potential and management
Authors: Lu Xiaoyue , Chen Hao , Zhang Taiping 
Published: March 2024

AbstractSolid pseudopapillary neoplasms (SPN) of the pancreas are presently recognized as low-grade malignant tumors that are frequently observed in young females. This tumor has a low incidence and is associated with an excellent prognosis following surgical resection. Typical SPNs primarily affect the pancreas and tend to have moderate or asymptomatic manifestations. Based on retrospective research, it is anticipated that patients with SPN can achieve disease-free survival, even in cases when metastasis is detected during inspection. However, the incidence of malignant SPN has been consistently underestimated, as evidenced by recent research findings. Malignancy of SPN primarily encompasses invasion and infiltration, metastasis, and recurrence after R0 resection. Imaging technologies such as Ultrasound, Computed Tomography, Magnetic Resonance Imaging, and Position Emission Tomography are capable of preliminarily identifying malignant SPN, which is primarily based on its invasive clinical features. Research on risk factors of malignant SPN revealed that larger tumor size, Ki-67 index, and several other parameters had significant correlations with invasive tumor behavior. Pathologic features of malignant SPNs overlay other pancreatic tumors, nevertheless they can provide valuable assistance in the process of diagnosis. Several confirmed specific pathologic biomarkers are related to its cellular origin, characteristic gene mutation, and cell proliferation. Considering the invasiveness of malignant SPN, it is imperative to enhance the comprehensiveness of its therapy. Tumor resection remains a suggested course of action in line with typical SPN, and additional lymph node dissection is seen as reasonable. Compared to benign SPNs, malignant SPNs have worse prognosis, underscoring the necessity of early identification and treatment in comprehensive medical centers to get improved clinical outcomes.