bluuebunny/crossref_metadata_2025_split huggingface dataset:
Akinetopsia: a systematic review on visual motion blindness
Authors: Browne Johanna L. , Krabbendam Lydia , Blom Jan Dirk 
Published: February 2025

BackgroundAkinetopsia, or visual motion blindness, is a perceptual distortion characteristic of Alice in Wonderland syndrome in which people see moving objects as disjointed ‘jumps’ or ‘freeze frames.’ Despite its profound impact, the condition remains poorly understood beyond the established centrality of cortical area V5/MT in visual motion perception.MethodsWe carried out a systematic review of case descriptions on motion blindness, including those where additional symptoms were described.ResultsOur search yielded data on 25 clinical and 27 experimental cases, the latter induced by cortical stimulation. Of the clinical cases, 12% showed hemiakinetopsia, 50% continuous or progressive symptoms, and 52% a chronic course. Pathophysiologically, in right-handed individuals, the left area V5/MT was found to be particularly susceptible to acute interference, as evidenced by the experimental studies. In contrast to earlier studies, we found a greater prevalence of right-hemispheric afflictions in clinical cases, suggesting that the right area V5/MT plays a more dominant role in motion perception. Bilateral lesions to V5/MT most often coincided with global akinetopsia and chronicity, although we found that the severity of the condition also depends on surviving components of the visual motion network as a whole, and—in line with the dynamic parallellism theory—the speed of moving objects. Aetiologically, most cases were associated with structural neurological conditions such as stroke and neurodegenerative disease, and fewer with intoxications or paroxysmal neurological disorders such as epilepsy. Treatments were mostly successful when they were aimed at the underlying condition, while cases due to organic lesions tended to be therapy-resistant. Although individual reports confirm that akinetopsia may have detrimental effects on people’s lives, data were insufficient for a proper analysis of such experiential aspects.ConclusionPhenomenologically, pathophysiologically, and etiologically, akinetopsia is more heterogeneous than previously thought. We provide recommendations for clinical practice and further scientific research.
The research progress on effective connectivity in adolescent depression based on resting-state fMRI
Authors: Deng Xuan , Cui Jiajing , Zhao Jinyuan , Bai Jinji , Li Junfeng , Li Kefeng 
Published: February 2025

IntroductionThe brain’s spontaneous neural activity can be recorded during rest using resting state functional magnetic resonance imaging (rs-fMRI), and intricate brain functional networks and interaction patterns can be discovered through correlation analysis. As a crucial component of rs-fMRI analysis, effective connectivity analysis (EC) may provide a detailed description of the causal relationship and information flow between different brain areas. It has been very helpful in identifying anomalies in the brain activity of depressed teenagers.MethodsThis study explored connectivity abnormalities in brain networks and their impact on clinical symptoms in patients with depression through resting state functional magnetic resonance imaging (rs-fMRI) and effective connectivity (EC) analysis. We first introduce some common EC analysis methods, discuss their application background and specific characteristics.ResultsEC analysis reveals information flow problems between different brain regions, such as the default mode network, the central executive network, and the salience network, which are closely related to symptoms of depression, such as low mood and cognitive impairment. This review discusses the limitations of existing studies while summarizing the current applications of EC analysis methods. Most of the early studies focused on the static connection mode, ignoring the causal relationship between brain regions. However, effective connection can reflect the upper and lower relationship of brain region interaction, and provide help for us to explore the mechanism of neurological diseases. Existing studies focus on the analysis of a single brain network, but rarely explore the interaction between multiple key networks.DiscussionTo do so, we can address these issues by integrating multiple technologies. The discussion of these issues is reflected in the text. Through reviewing various methods and applications of EC analysis, this paper aims to explore the abnormal connectivity patterns of brain networks in patients with depression, and further analyze the relationship between these abnormalities and clinical symptoms, so as to provide more accurate theoretical support for early diagnosis and personalized treatment of depression.
Efficacy of electroacupuncture for insomnia in cancer patients: a systematic review and meta-analysis
Authors: Liu Xiaodong , Xu Ning , Wang Shangpei , Jia Qingjun 
Published: February 2025

BackgroundInsomnia is a prevalent symptom among cancer patients. Electroacupuncture (EA) has been widely applied in managing sleep disorders, particularly in cancer patients or those experiencing insomnia.ObjectivesThis meta-analysis aims to evaluate the efficacy and safety of electroacupuncture for treating cancer-related insomnia.MethodsTwo independent reviewers conducted comprehensive searches across multiple databases, including EMBASE, Web of Science, PubMed, the Cochrane Library, Wanfang Digital Journals, China National Knowledge Infrastructure (CNKI), and the VIP Database for Chinese Technical Periodicals. The search was completed on April 28, 2024. The reviewers independently performed literature screening, data extraction, and risk of bias (ROB) assessment using the revised Cochrane ROB tool. Data were analyzed using RevMan 5.4 and Stata 15.0 software.ResultsEight randomized controlled trials (RCTs) involving 550 patients (305 in the experimental group and 245 in the control group) were included. EA significantly reduced Pittsburgh Sleep Quality Index (PSQI) scores (SMD = −0.86, 95% CI [−1.24, −0.49], p &lt; 0.001), Insomnia Severity Index (ISI) scores (SMD = −1.14, 95% CI [−1.59, −0.69], p &lt; 0.001), sleep latency (SL) (SMD = −0.48, 95% CI [−0.73, −0.23], p &lt; 0.001), and sleep disturbance (SDB) (SMD = −0.44, 95% CI [−0.73, −0.16], p = 0.002). EA also significantly lowered Hospital Anxiety and Depression Scale-Anxiety (HADS-Anxiety) scores (SMD = −0.59, 95% CI [−0.91, −0.26], p &lt; 0.001) and Hospital Anxiety and Depression Scale-Depression (HADS-Depression) scores (SMD = −0.73, 95% CI [−1.06, −0.40], p &lt; 0.001), while increasing total sleep time (TST) (SMD = 0.65, 95% CI [0.14, 1.17], p = 0.013). No significant differences were observed in the Athens Insomnia Scale (AIS), sleep duration (SD), sleep efficiency (SE), or sleep quality (SQ) scores between the EA and control groups.ConclusionElectroacupuncture has shown promising potential in treating cancer-related insomnia by increasing total sleep time and reducing sleep disturbances. However, additional high-quality studies are necessary to validate these findings.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=567567, Identifier CRD42024567567.
Pan-caspase inhibitor protects against noise-induced hearing loss in a rodent model
Authors: Yepes Maria Fernanda , Minesinger Kayla , Raciti Federica M. , Salazar Maria Camila , Rajguru Suhrud M. 
Published: February 2025

BackgroundDespite the high prevalence of noise-induced hearing loss (NIHL), no effective treatments exist currently. Underlying mechanisms behind NIHL include elevated reactive oxygen species and inflammation, all which ultimately lead to cellular apoptosis. Z-VAD-FMK, an apoptosis inhibitor, has demonstrated protective effects against cochlear hair cells exposed to ototoxic agents; however, its potential for treating NIHL remains unexplored. This study assessed the efficacy of Z-VAD-FMK as a therapeutic for noise-induced cochlear injury in a rodent model.MethodsRodents were assigned to one of four groups: (1) unexposed, (2) noise-exposed, (3) noise + vehicle, and (4) noise + Z-VAD-FMK. Noise delivery consisted of 1 h of 110 dB continuous white-noise, with Z-VAD-FMK administered intraperitoneally 6 h afterward. Auditory brainstem responses (ABRs), cochlear hair cell density, and protein levels were evaluated post-interventions.ResultsNoise exposure caused a permanent threshold shift across all frequencies, with minimal recovery by day 28. However, post-exposure treatment with Z-VAD-FMK significantly mitigated ABR threshold, amplitudes, and latencies shifts particularly at low and mid frequencies. Treatment rescued outer hair cells across middle and basal cochlear turns and reduced caspase-9 and IL-1β levels, as indicated by protein analysis.ConclusionOur findings indicate that a single intraperitoneal injection of Z-VAD-FMK can partially mitigate cochlear dysfunction induced by acoustic overexposure in a rodent model, highlighting its potential as a therapeutic intervention for NIHL.
Efficacy and safety of transanal endoscopic microsurgery for early rectal cancer: a meta-analysis
Authors: Wang Chunqiang , Huang Tianye , Wang Xuebing 
Published: February 2025

BackgroundThe gold standard for the treatment of rectal cancer is radical surgery with total mesorectal excision (TME). As one of the alternatives to radical surgery, local resection has been proposed for the treatment of early rectal cancer. The purpose of this article was to evaluate the safety and efficacy of transanal endoscopic microsurgery (TEM) in the treatment of early rectal cancer.MethodsBy searching the PubMed, Cochrane Library, Web of Science, and China National Knowledge Infrastructure databases, we selected all articles on TEM for early rectal cancer. Two researchers independently completed the entire process from screening, inclusion to data extraction and performed statistical analysis using RevMan 5.3. The primary outcomes included basic patient characteristics, overall survival rate, disease-free survival rate, disease-specific survival rate, recurrence rate, and complication rate and type.ResultsA total of 33 articles were included in this meta-analysis. The results showed that the overall survival rate was 100% for T0 stage, 98.1% for Tis (carcinoma in situ) stage, and 80.2% for early stage rectal cancer patients (83.9% for T1 and 72.4% for T2). The weighted overall survival rate was 94% (RD = 0.94, 95% CI = 0.93–0.95, I2 = 80%, P &lt; 0.00001) for all stage patients, the weighted disease-free survival rate was 91% (RD = 0.91, 95% CI = 0.90–0.93, I2 = 83%, P &lt; 0.00001), and the disease-specific survival rate was 97% (RD = 0.97, 95% CI = 0.96–0.98, I2 = 63%, P &lt; 0.00001). The recurrence rate was 0.5% for T0 stage, 1.9% for Tis stage, and 11.9% for early stage rectal cancer patients (8.1% for T1 and 19.7% for T2). The weighted recurrence rate was 7% (RD = 0.07, 95% CI = 0.06–0.08, I2 = 69%, P &lt; 0.00001) for all stage patients. The weighted complications rate was 11% (RD = 0.11, 95% CI = 0.10–0.12, I2 = 66%, P &lt; 0.00001) for all stage patients, with Clavien-Dindo grade I accounting for 77.7%, Clavien-Dindo grade II accounting for 8%, and Clavien-Dindo grade III accounting for 14.3%.ConclusionThe results showed that TEM has a high postoperative survival rate, low recurrence rate, and low complication rate in the T0 stage, Tis stage, and T1 stage, indicating its good safety and efficacy. For the treatment of T2 stage, TEM has a lower overall survival rate and a higher recurrence rate. Our meta-analysis results suggest that TEM alone is not recommended as a curative treatment for T2 stage; on the contrary, TME is more frequently recommended.
Exploring the multi-targeted mechanism of Saikosaponin A in prostate cancer treatment: a network pharmacology and molecular docking approach
Authors: Zhu Genbao , Jiang Zhiming , Zhu Niuping , Wang Donghui , Guo Tianpeng , Meng Yiqing , Zhu Yi , Tan Kemeng , Hu Mengxue , Tang Heng , Wang Xuannian 
Published: February 2025

BackgroundProstate cancer (PCa) is one of the prevalent malignant tumors among men. It can progress to castration-resistant prostate cancer (CRPC), which is significantly more challenging to treat. Saikosaponin A (SSA), a triterpenoid saponin extracted from the genus Bupleurum, exerts numerous pharmacological effects, including anti-inflammatory and anti-tumorigenic effects. However, the mechanism underlying the effects of SSA in prostate cancer treatment remains elusive.MethodsIn this study, a network pharmacology approach was applied to identify relevant targets from drug- and disease-related databases, and intersections were analyzed using Venny2.1 to construct a Protein-Protein interaction (PPI) interaction network. Next, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed to elucidate associated biological functions and signaling pathways. Meanwhile, molecular docking between core targets and SSA was performed using Autodock software. Lastly, in vitro experiments were performed for validation.ResultsA least of four key targets, namely BCL2 apoptosis regulator (BCL2), estrogen receptor 1 (ESR1), hypoxia-inducible factor 1 subunit alpha (HIF1A), and signal transducer and activator of transcription 3 (STAT3) were identified in this study, and molecular docking analyses revealed that SSA stably binds to these targets. Moreover, the results of in vitro experiments revealed that SSA significantly inhibited the proliferative and migratory abilities of PC3 cells in a dose-dependent manner. Finally, SSA also induced G1-phase blockade and apoptosis in PC3 cells, further highlighting its potential role in prostate cancer treatment.ConclusionThe present study revealed that SSA exerts anti-tumorigenic effects in prostate cancer by targeting multiple pathways, laying a theoretical reference for its use as a therapeutic candidate for prostate cancer.
Gesture sonification for enhancing agency: an exploratory study on healthy participants
Authors: Schoeller Felix , Ashur Parham , Larralde Joseph , Le Couedic Clement , Mylapalli Rajeev , Krishnanandan Karthikeyan , Ciaunica Anna , Linson Adam , Miller Mark , Reggente Nicco , Adrien Vladimir 
Published: February 2025

BackgroundBody awareness (BA) and proprioception, which are essential components of the sense of agency (SA), are often altered in various mental disorders such as posttraumatic stress disorder (PTSD). However, the relationship between BA, proprioception, and SA, as well as the methods to manipulate them, remain unclear. This study explored using real-time gesture sonification (GS), i.e., wearable technology transforming body movements into sounds, to enhance proprioception, BA, and thus the SA.MethodsIn this within-subjects design, 17 healthy adults (mean age = 25.5 years) with varying dance expertise (novice, amateur, expert) improvised movements to match sounds with and without auditory feedback from motion sensors on wrists/ankles modulated by their gestures. BA, immersion, pleasure, and self-efficacy were measured.ResultsSonification significantly increased body awareness, reward, and immersion (all p &lt; 0.05).ConclusionGS can enhance BA and the SA, pleasure, and control during physical activity. This highlights potential mental health applications, such as agency-based therapies for PTSD. Manipulating bodily perception could improve symptoms and embodiment. Further research should replicate this in clinical populations and explore neurocognitive mechanisms.
Association analysis of suicide risk assessed with Mini International Neuropsychiatric Interviews’ Suicidality Module in adolescents with non suicidal self injury disorder
Authors: Geng Shuo , Zhang Wen , Gao Xiang , Qu Lele , Zheng Xueping , Sun Jian , Xu Mingdong , Lin Hua , Jia Xueyu , Zhang Xu 
Published: February 2025

ObjectiveMany adolescents with non suicidal self injury disorder have suicidal ideation. However, the specific characteristics of adolescents with NSSI-D that contribute to high suicide risk remain unclear. This study observes the association between depressive and anxiety symptoms and suicide risk among adolescents with non suicidal self injury disorder, and explores the mechanism underlying the high risk of suicide in this population.MethodAdolescents with non suicidal self injury disorder and their parents from a psychiatric outpatient clinic were selected to conduct paper questionnaires to measure their sociodemographic conditions. The Mini International Neuropsychiatric Interviews’ Suicidality Module(MINISM) was used to assess suicide risk of participants. The Self-Rating Depression Scale(SDS), Self-Rating Anxiety Scale(SAS), and Piers-Harris Children’s Self-Concept Scale(PHCSS) were used to measure depressive and anxiety symptoms, and self-concept of adolescents with non suicidal self injury disorder. According to the high suicide risk cutoff value of MINISM, the sample was divided into high suicide risk group and non-high suicide risk group. We performed descriptive and correlation statistical and network analysis to study the types of depressive and anxiety symptoms associated with suicide risk and the mechanism underlying suicide risk among non suicidal self injury disorder adolescents.ResultsA total of 112 non suicidal self injury disorder adolescent participants were included in this study. Severe depressive symptoms(OR=8.205, 95%CI=3.454-19.490) and severe anxiety symptoms(OR=3.926, 95%CI=1.613-9.554) are associated with a high risk of suicide. The father’s college/university education(p&lt;0.01) is associated with severe anxiety symptoms, and low self-concept(p&lt;0.01) is associated with severe depressive symptoms. Network analysis suggests the centrality of anxiety symptoms and father’s education level.ConclusionThe results of statistical analysis suggest that severe depressive symptoms are related to the high risk of suicide (based on MINISM) in adolescents with NSSI-D statistical significantly, and anxiety symptoms and low self-concept are associated with depressive symptoms in NSSI-D adolescents. Interventions targeting anxiety symptoms in adolescents with NSSI-D may help reduce their suicide risk.
Consumption, relative deprivation and mental health: evidence from hedonic consumption
Authors: Li Hao , Zeng Weihong 
Published: February 2025

IntroductionIn recent years, relative deprivation related to consumption has sparked intense debate, particularly as the COVID-19 pandemic caused incalculable economic losses worldwide. However, the relationship between relative deprivation related to consumption and mental health remains largely unexplored. This study investigates how both vertical (household-level) and horizontal (household-to-household) relative deprivation related to consumption affect mental health, with a focus on hedonic consumption, and identifies underlying channels and moderating factors.MethodsWe analyze data from the China Family Panel Studies (CFPS) covering 88,144 observations from 2010 to 2018. Hedonic consumption is measured through expenditure on items such as jewelry, antiques, and entertainment, while consumption inequality is assessed using the Kakwani index. Mental health is evaluated using the CES-D and Kessler 6 scales. Ordinary least squares (OLS) and two-stage least squares (2SLS) methods are employed.ResultsOur findings show that reductions in hedonic consumption negatively impact mental health, with involuntary and sudden declines resulting in more pronounced deterioration. Furthermore, greater consumption inequality exacerbates mental health issues, and perceived unfair treatment amplifies this effect. Additionally, self-perception and trust levels are identified as key channels through which these effects. Furthermore, cultural variations and social capital are moderating roles to diminish the adverse mental health.ConclusionThis study advances our understanding of how relative deprivation related to consumption affects mental health and offers valuable insights for policymakers and practitioners aiming to address these challenges.
Status and influencing factors of health literacy among college students of traditional Chinese medicine: a cross-sectional study
Authors: Zhu Jie , Lin Cuixia , Yang Yanhui , Yao Rui , Yang Ran , Jiang Mingqian 
Published: February 2025

BackgroundCollege students, as the future strength of national development, have a high level of health literacy in line with the goal of “Healthy China”, but the current research found that the health literacy level of college students is uneven and needs to be improved, and there is still a lack of research on the health literacy of students in colleges and universities of traditional Chinese medicine (TCM). Therefore, this study aims to assess the health literacy level of students in TCM colleges and analyze its influencing factors, so as to provide a basis for implementing effective health literacy intervention measures and building healthy schools.MethodsUsing the convenient sampling method, 925 college students in a TCM university in Shandong Province were selected to conduct an online electronic questionnaire survey using “Questionnaire Star” from December 2022 to March 2023. SPSS 22.0 software was used to process and analyze the data. Descriptive statistical analysis was used to analyze the general data of the respondents, chi-square test was used to compare the count data between groups, and Logistic regression model was used to analyze the influencing factors of health literacy.ResultsThe health literacy level of TCM college students was 57.30%. Among the three aspects of health literacy, the level from high to low was: healthy lifestyle and behavior literacy (65.41%), health skill literacy (58.70%) and basic knowledge and concept literacy (53.62%). Among the six categories of health literacy, the level of scientific health literacy (79.68%) was the highest, followed by safety and first aid literacy (72.86%), health information literacy (61.62%), basic medical literacy (61.30%), chronic disease prevention literacy (60.11%) and infectious disease prevention literacy (40.86%). The results of multifactorial logistic regression analyses showed that females (AOR: 1.92; 95%CI: 1.40–2.62), college seniors (AOR: 2.02; 95%CI: 1.01–4.05), never smokers (AOR: 2.99; 95%CI: 1.57–5.72), and awareness of the concept of “health literacy” (AOR: 1.54; 95%CI: 1.11–2.13) were protective factors for health literacy, and the health literacy level of students in TCM colleges and universities was statistically significantly positively correlated with their health literacy level (p &lt; 0.050).ConclusionCompared with most studies at home and abroad, the overall level of health literacy among students of TCM colleges is high. The healthy lifestyle and behavior literacy of students in TCM colleges is better than knowledge and skill literacy, which is manifested as the separation of knowledge and practice. Gender, grade, smoking or not, being aware of the concept of “health literacy” are the influencing factors of health literacy level of students in TCM colleges.