bluuebunny/crossref_metadata_2025_split huggingface dataset:
Magnetic resonance enterography findings 46 weeks after initiation of biological therapy predict long‐term adverse outcomes in Crohn's disease
Authors: Fernández‐Clotet Agnès , Ordás Ingrid , Masamunt Maria Carme , Caballol Berta , Rodríguez Sonia , Gallego Marta , Barastegui Rebeca , Saavedra Anny Carolina , Panés Julián , Ricart Elena , Rimola Jordi 
Published: April 2024

SummaryBackground and AimsMagnetic resonance enterography (MRE) depicts transmural changes in response to biological treatment for Crohn's disease (CD); however, the long‐term prognostic significance of these findings is unknown. The primary objective of this study was to identify findings on MRE 46 weeks after initiating biological treatment that predict adverse long‐term outcomes.MethodsPatients with CD underwent MRE 46 weeks after initiating biological treatment and were prospectively followed for 2 years. A logistic regression analysis was performed to assess the prognostic value of different radiologic findings for various predefined adverse outcomes.ResultsOf the 89 patients included, 46 (51.7%) had ≥1 adverse outcome during follow‐up: 40 (44.9%) had clinical recurrence; 18 (20.2%) required surgery, 8 (9%) endoscopic balloon dilation, 12 (13.5%) hospitalization and 7 (7.8%) required corticosteroids. In the multivariate analysis, persistence of severe lesions (MaRIA ≥11) in any intestinal segment was associated with an increased risk of surgery [OR 11.6 (1.5–92.4)], of surgery and/or endoscopic balloon dilation [OR 6.3 (1.3–30.2)], and of clinical relapse [OR 4.6 (1.6–13.9)]. Penetrating lesions were associated with surgery [OR 3.4 (1.2–9.9)]. Creeping fat with hospitalization [OR 5.1 (1.1–25.0)] and corticosteroids requirement [OR 16.0 (1.2–210.0)]. The presence of complications (stricturing and/or penetrating lesions) was associated with having ≥1 adverse outcome [OR 3.35 (1.3–8.5)].ConclusionMRE findings at week‐46 after initiating biological therapy can predict long‐term adverse outcomes in CD. Therapeutic intervention may be required in patients with persistence of severe inflammatory lesions, CD‐associated complications, or creeping fat.
Diagnostic delay of MYH9‐related disorder in Japan
Authors: Sakamoto Atsushi , Uchiyama Toru , Kaname Tadashi , Iguchi Akihiro , Ohara Osamu , Ishimura Masataka , Onum Masaei , Kunishima Shinji , Ishiguro Akira 
Published: April 2024

SummaryMYH9‐related disorder (MYH9‐RD) is characterized by congenital macrothrombocytopenia and granulocyte inclusion bodies. MYH9‐RD is often misdiagnosed as chronic immune thrombocytopenia. In this study, we investigated age at definitive diagnosis and indicative thrombocytopenia in 41 patients with MYH9‐RD from the congenital thrombocytopenia registry in Japan. Our cohort comprises 54.8% adults over 18 years at confirmed diagnosis. We found a significant difference (p < 0.0001) between the median age at definitive diagnosis of 25.0 years and for indicative thrombocytopenia it was 9.0 years. Our findings strongly suggest diagnostic delay of MYH9‐RD in Japan. Our registry system will continue to contribute to this issue.
Chronotype and subjective sleep quality predict white matter integrity in young people with emerging mental disorders
Authors: Crouse Jacob J. , Park Shin Ho , Hermens Daniel F. , Lagopoulos Jim , Park Minji , Shin Mirim , Carpenter Joanne S. , Scott Elizabeth M. , Hickie Ian B. 
Published: April 2024

AbstractProtecting brain health is a goal of early intervention. We explored whether sleep quality or chronotype could predict white matter (WM) integrity in emerging mental disorders. Young people (N = 364) accessing early‐intervention clinics underwent assessments for chronotype, subjective sleep quality, and diffusion tensor imaging. Using machine learning, we examined whether chronotype or sleep quality (alongside diagnostic and demographic factors) could predict four measures of WM integrity: fractional anisotropy (FA), and radial, axial, and mean diffusivities (RD, AD and MD). We prioritised tracts that showed a univariate association with sleep quality or chronotype and considered predictors identified by ≥80% of machine learning (ML) models as ‘important’. The most important predictors of WM integrity were demographics (age, sex and education) and diagnosis (depressive and bipolar disorders). Subjective sleep quality only predicted FA in the perihippocampal cingulum tract, whereas chronotype had limited predictive importance for WM integrity. To further examine links with mood disorders, we conducted a subgroup analysis. In youth with depressive and bipolar disorders, chronotype emerged as an important (often top‐ranking) feature, predicting FA in the cingulum (cingulate gyrus), AD in the anterior corona radiata and genu of the corpus callosum, and RD in the corona radiata, anterior corona radiata, and genu of corpus callosum. Subjective quality was not important in this subgroup analysis. In summary, chronotype predicted altered WM integrity in the corona radiata and corpus callosum, whereas subjective sleep quality had a less significant role, suggesting that circadian factors may play a more prominent role in WM integrity in emerging mood disorders.
Virtual gown and town: The Athabasca University crisis and the conflict of institutional logics
Authors: Jones Glen A. 
Published: April 2024

AbstractThe objective of this paper is to contribute to our understanding of ‘crisis’ in higher education through the analysis of a unique series of events involving a decisive change in the relationship between a university and the state. A descriptive case study approach is used to investigate the crisis in governance at Athabasca University, an open university located in Alberta, Canada. Factors leading to the crisis included the university leadership's decision to move forward with plans to become a near‐virtual organization, concerns by local town that a loss of university employees in the region would be an economic catastrophe, and political opportunism on the part of the elected provincial leaders who decided to address the problems raised by the town and shift the mandate of the university. Drawing on institutional theory and the concept of institutional logics, the paper analyses the episodic nature of the crisis and explores both the nature of the conflict and its resolution.
The association between the adverse event reporting system and burnout and job satisfaction of nurses: Workplace violence as a mediator
Authors: Chen Yanhua , He Yanrong , Wang Peicheng , Jiang Feng , Du Yanrong , Cheung Ming Yen , Liu Huanzhong , Liu Yuanli , Liu Tingfang , Tang Yi‐lang , Zhu Jiming 
Published: April 2024

AbstractAimsThis study aims to explore the association between the implementation of the adverse event reporting system (AERS), burnout, and job satisfaction among psychiatric nurses, with a focus on examining the mediating effect of workplace violence from patients.BackgroundMany organizational and personal factors contribute to burnout and job satisfaction experienced by nurses. AERS, serving as a key component of organizational‐level quality improvement system, impacts the overall workplace wellness of nurses.MethodsA national sample of 9,744 psychiatric nurses from 41 psychiatric hospitals across 29 provinces in China participated. Burnout was measured by the Maslach Burnout Inventory. Job satisfaction was measured using the Minnesota Satisfaction Questionnaire. Workplace violence was assessed by nurses’ experience of verbal and physical violence. Multilevel linear regression analyses were carried out to examine if AERS impacts burnout and job satisfaction and to identify the mediating role of workplace violence.ResultsAERS was positively associated with job satisfaction, but negatively with burnout and workplace violence. Workplace violence exhibited a positive association with burnout and a negative association with job satisfaction. Mediation analyses indicated that the associations between AERS, burnout, and job satisfaction were mediated by workplace violence.ConclusionsThe application of AERS is associated with a reduction in workplace violence in hospitals, which contributes to the diminished burnout and heightened job satisfaction among psychiatric nurses.Implications for nursing practice and health policyThe study highlights the importance of organizational efforts and mechanisms in promoting nurses’ well‐being. It is necessary for hospital management to create a safe workplace through the implementation of AERS.
RETRACTED: Influences of evidence‐based nursing intervention on pressure ulcers in intensive care units: A meta‐analysis
Authors: Xu Yan‐Bing , Chen Zhi‐Qiang , Su Xiao‐Hong , Cao Ying 
Published: April 2024

AbstractA meta‐analysis was conducted comprehensively to investigate the impact of evidence‐based nursing (EBN) interventions on pressure injury (PI) in the intensive care unit (ICU) patients. Computer searches were performed, from databases inception to November 2023, in Wanfang, PubMed, China National Knowledge Infrastructure, Google Scholar, Embase, and Cochrane Library for randomized controlled trials (RCTs) on the application of EBN interventions in ICU patients. Two independent researchers conducted screenings of the literature, extracted data, and carried out quality evaluations. Stata 17.0 software was employed for data analysis. Overall, 25 RCTs, involving 2494 ICU patients, were included. It was found that compared to conventional care methods, the implementation of EBN interventions in ICU patients markedly decreased the occurrence of PI (odds ratio [OR]: 0.22, 95% confidence interval [CI]: 0.17–0.30, p < 0.001), delayed the onset time of pressure ulcers (standardized mean difference [SMD]: −1.61, 95% CI: −2.00 to −1.22, p < 0.001), and also improved nursing satisfaction (OR: 1.18, 95% CI: 1.14–1.23, p < 0.001). Our findings suggest the implementation of EBN interventions in the care of PI in ICU patients is highly valuable, can reduce the occurrence of PI, can delay the time of appearance, and is associated with relatively higher nursing satisfaction, making it worthy of promotion.
RETRACTED: The effect of negative pressure wound therapy on the outcome of diabetic foot ulcers: A meta‐analysis
Authors: Zhang Ning , Liu Yibin , Yan Weiqi , Liu Fei 
Published: April 2024

AbstractNegative pressure injury is one of the auxiliary methods of treating diabetes foot ulcers. It has been shown to be superior to conventional techniques in randomized controlled trials (RCTs). Nevertheless, the results of observational research are still scarce. A systematic review of RCTs and observations was carried out to evaluate the effectiveness and security of negative pressure wound therapy (NPWT) treatment for diabetes foot ulcers. Three English e‐databases have been found for NPWT research. The meta‐analyses of the comparative studies provided point estimates of results. Intermediate results were given as median and binary values were given in the form of odds ratios (OR). Seventeen trials, 13 RCTs and four randomized, controlled trials were found in the survey. Of these, 831 were treated with NPWT, 834 were treated with standard therapy. A total of 14 studies have been conducted to investigate the influence of NPWT on the healing of diabetic foot ulcers(DFU). In the study, NPWT was shown to speed up the healing of the wound in DFU patients(OR, 2.57; 95% CI, 1.72, 3.85 p < 0.0001). A subgroup analysis showed that NPWT was associated with an acceleration of the wound healing rate in 10 RCT trials (OR, 2.48; 95% CI, 1.58, 3.89 p < 0.001). In the four nRCT trials, NPWT was also shown to speed up the healing of the wound(OR, 2.95; 95% CI, 1.03, 8.42 p = 0.04). In 11 studies, the influence of NPWT on amputations of diabetes mellitus (DM) foot ulcers was investigated. The results showed that NPWT was associated with a reduction in amputations (OR, 0.53; 95% CI, 0.37, 0.74 p = 0.0002).In a subgroup of RCT trials, nine RCT trials showed a reduction in amputations(OR, 0.61; 95% CI, 0.43, 0.87 p = 0.007). In both nRCT trials, NPWT also showed a reduction in amputations (OR, 0.03; 95% CI, 0.00, 0.24 p = 0.001). Generally speaking, NPWT can help to heal the wound and lower the risk of amputations in people with diabetes. The subgroup analysis showed similar results for the RCT and non‐RCT trials. NPWT can be used to treat diabetes foot ulcers caused by diabetes.
Estimated reproductive parameters for a vulnerable Australian humpback dolphin population
Authors: Hawkins Elizabeth R. , Dunleavy Merryn 
Published: April 2024

AbstractUnderstanding reproductive output and success is integral to the conservation and management of threatened species and populations. Little is known about the reproductive parameters of Australian humpback dolphins (Sousa sahulensis), a species subject to cumulative pressures from anthropogenic threats due to their coastal distribution and strong site fidelity. This study assesses several reproductive parameters, including crude birth, recruitment, fecundity, and calf survival rates, in addition to interbirth intervals of Australian humpback dolphins inhabiting the near‐urban embayment of Moreton Bay, Queensland. Between 2014 and 2020, 106 adult females were photographically identified during 222 boat surveys. Of these, 75.5% (n = 80) were observed with calves. Birth seasonality was apparent and coincided with austral autumn and winter months. Interbirth intervals ranged between 1 and >6 years, with an average of 3.1 (SD = 1.1) years if offspring survived. Findings indicate declining fecundity rates (p < .05, M = 0.12, SD = 0.02), relatively low recruitment rates (M = 0.04, SD = 0.01) and calf survival rates to 1 year of age (M = 0.63, SD = 0.15). This study provides a useful baseline that can inform viability assessments and conservation measures, for both this population and others throughout the species range.
Small intestinal bacterial overgrowth in diabetic gastroenteropathy
Authors: Varma Revati , Chakraborty Subhankar , Burton Duane D. , Bailey Kent R. , Bharucha Adil E. 
Published: April 2024

AbstractBackgroundAlthough diabetic gastroenteropathy (DGE) is associated with small intestinal bacterial overgrowth (SIBO), most studies have evaluated SIBO with a hydrogen breath test, which may be affected by altered transit in DGE. The risk factors for the consequences of SIBO in DGE are poorly understood. We aimed to evaluate the prevalence of, risk factors for, and gastrointestinal symptoms associated with SIBO in patients with DGE.MethodsIn 75 patients with DGE and dyspepsia, we tested for SIBO (≥105 colony forming units /mL of aerobic and/or anaerobic bacteria in a duodenal aspirate) and assessed gastric emptying (GE) of solids, symptoms during a GE study and during an enteral lipid challenge (300 kcal/2 h), and daily symptoms with a Gastroparesis Cardinal Symptom Index diary for 2 weeks. Symptoms and GE were compared in patients with versus without SIBO.Key ResultsOf 75 patients, 34 (45%) had SIBO, which was not associated with the use of proton pump inhibitors, daily symptoms, GE, or symptoms during a GE study. During enteral lipid challenge, severe nausea (p = 0.006), fullness (p = 0.02) and bloating (p = 0.009) were each associated with SIBO. Twenty patients (59%) with versus 13 (32%) without SIBO had at least one severe symptom during the lipid challenge (p = 0.006).Conclusions & InferencesAmong patients with DGE 45% had SIBO, which was associated with symptoms during enteral lipid challenge but not with delayed GE, symptoms during a GE study, or daily symptoms. Perhaps bacterial products and even fatty acids are recognized by and activate mast cells that drive the increased lipid sensitivity in SIBO.
The efficiency of public expenditures on basic services: The case of South African municipalities
Authors: Adedeji Amusa Hammed , Fadiran David 
Published: April 2024

AbstractThis paper examines the efficiency of service delivery across 213 local and metropolitan municipalities in South Africa, focusing on four critical areas: electricity, water, sewerage and waste removal. Utilising a order‐
partial frontier efficiency analysis (PFEA), the study calculates output‐oriented efficiency scores for each municipality, incorporating adjustments for service quality based on an ‘infrastructure quality‐index’. Our empirical findings indicate marked variations in efficiency, with electricity services exhibiting the highest efficiency rate at 35%, while waste removal lags behind at 22%. Additionally, municipalities centred around small urban towns are found to be more efficient, challenging the widely held view that larger municipalities are better equipped for efficient service delivery. The analysis offers empirical insights into local government performance in South Africa, underscoring the need for targeted policy interventions to address efficiency gaps. These results not only inform fiscal and administrative decentralisation strategies but also set the groundwork for future research exploring the underlying factors affecting municipal efficiency.
Blockchain Database for Improved Recording of Property Deeds
Authors: Zeid Abe , Cohen Dylan , Justice Eva , Mendoza Sofia , Schlagman Eliana , Simon Sarah 
Published: April 2024

Abstract
The current manual process for property deed recording lacks automation, efficiency, and transparency. Real estate transactions require disjointed efforts from multiple parties, and they only become legally binding once they are recorded in a public, physical repository: the Registry of Deeds. Sensitive information is centralized, leaving it vulnerable to misuse, fraudulent activity, and destruction. A blockchain database offers real-time traceability for transactions and a peer-to-peer network to connect the tasks of attorneys, title agents, notaries, grantors, and grantees into a seamless process. Records in a blockchain database are immutable and protected from misuse. Replacing the manual recording process with an automated blockchain eliminates waste in time, money, and third-party efforts, providing grantors and grantees with added protection in the legitimacy of their transactions. This paper aims to provide a proof-of-concept prototype to replace the current paper-based traditional process with an electronic-based blockchain process. A full replacement of the existing relational database will improve throughput, error rates, and cycle times in the recording process. The solution comprises an immutable, decentralized blockchain database of property deeds with an interactive website to add and query records.
Exploring the Influence of Requirement Representation on Idea Generation
Authors: Patel Akash , Summers Joshua D. , Morkos Beshoy , Karmakar Sourabh 
Published: April 2024

Abstract
The objective of this research is to understand how different representations of requirements influence idea generation in terms of quantity, addressment, novelty, and variety of conceptual sketches. Requirements are testable statements of need, desires, and wishes of the stakeholders that are used by engineers to frame the problem. Project success is highly dependent on well-defined requirements documents. An experimental study was conducted with 52 fourth-year mechanical engineering undergraduate students. Two design problems are used with three different representations: a problem statement with embedded requirements, a problem statement and a traditional requirement list, and a problem statement with contextualized scrum stories. Each student addressed both design problems with two different representations of requirements. It was found that the use of contextualized scrum story representations significantly affected the novelty of solution fragments and addressment of requirements, while no significant change in variety and quantity was seen. Finally, it was found that quantity is not directly related to the number of requirements addressed in the sketches.
Optimal Positioning of Small Wind Turbines Into a Building Using On-Site Measurements and Computational Fluid Dynamic Simulation
Authors: Vallejo Díaz Alexander , Herrera Moya Idalberto , Castellanos Juan E. , Garabitos Lara Edwin 
Published: April 2024

Abstract
Renewable energy solutions are essential for addressing several pressing issues, including climate change, the fossil fuels supply chain fragility and fuel price fluctuations. One promising technological solution is rooftop-mounted turbines into buildings. This study presents an evaluation of the potential for wind energy utilization on the rooftop of a 29 m tall building. The primary objective of this research is to develop a methodology that can effectively investigate the integration of small wind turbines (SWTs) into urban buildings, intending to promote energy sufficiency in urban areas. A robust framework has been developed that consists of seven steps. These steps include site selection, evaluating urban wind energy with computational fluid dynamics (CFD) simulation and on-site measurements, selecting an appropriate SWT, estimating the annual energy production (AEP), conducting an evaluation of the environmental impact, resilience, and economic analysis, and finally, installing the system. This straightforward yet reliable framework provides a comprehensive approach to assessing the viability of wind energy utilization in urban areas. The findings revealed that the most suitable location for installation had an estimated AEP of around 1030 kWh, leading to a reduction in emissions of 0.64 tCO2/y. Additionally, it was observed that the building's geometry and orientation significantly affected the wind flow, causing a substantial decrease in wind speed downstream. Selecting optimal sites and considering wind patterns are essential for maximizing energy generation in wind energy projects.
Bacterial genome sequences of uncharacterized
Chitinophaga
species isolated from the International Space Station
Authors: Castro Christian L. , Schwengers Oliver , Stahl-Rommel Sarah , Nguyen Hang N. , Dunbar Brandon , Wallace William T. , Castro-Wallace Sarah L. 
Published: April 2024

ABSTRACT

We report four
Chitinophaga
sp. strains isolated from wastewater collected onboard the International Space Station. Here, we present three finished and one draft genome. Taxonomic ranks established by genome-based analysis indicate that these
Chitinophaga
sp. strains represent candidates for a new species.