bluuebunny/crossref_metadata_2025_split huggingface dataset:
Productivity dynamics of work from home: Firm-level evidence from Japan
Authors: Morikawa Masayuki 
Published: February 2024

AbstractThis study documents the changes in work from home (WFH) practices since the onset of the COVID-19 pandemic using panel data from original firm surveys in Japan. Particular attention has been given to the productivity dynamics of WFH. The results indicate the following: First, compared to when the first state of emergency was declared in the spring of 2020, at the end of 2021, the ratio of firms utilizing WFH and the intensity of WFH decreased substantially. Second, according to the firms’ evaluations, the mean productivity of WFH improved by more than 10 percentage points, although it was still approximately 20% lower than that of conventional workplaces. The selection effect arising from the exit from this practice among firms with low WFH productivity, and the improvement in productivity among WFH-continuing firms contributed almost equally to the average productivity growth. Third, the majority of firms are planning to discontinue WFH practices and revert to the conventional work style or to reduce WFH intensity after the end of COVID-19, and the gap between firms’ plans and the desire of remote workers is widening.
Low incidence of tumor lysis syndrome in elderly patients with chronic lymphocytic leukemia treated with venetoclax under real-world conditions: results from the prospective observational VeRVe study
Authors: Schwaner Ingo , Kuhn Thomas , Losem Christoph , Wolff Thomas , Otremba Burkhard , Zaiss Matthias , Hülsenbeck Johannes , Famulla Kirsten , Nösslinger Thomas , Rossi Davide 
Published: February 2024

AbstractVenetoclax is active in both frontline and relapsed/refractory settings for the treatment of chronic lymphocytic leukemia (CLL). Although the prevalence and severity of tumor lysis syndrome (TLS) are well characterized in clinical trials, laboratory and clinical TLS remain relatively unexplored in real-world clinical practice.In this prospective, real-world observational study, we aimed to determine the incidence and outcomes of TLS in patients with CLL receiving venetoclax outside a clinical trial. The study (VeRVe) was conducted in centers in Austria, Germany, and Switzerland.Two hundred and thirty-nine patients were treated according to local label with at least one dose of venetoclax. Patient demographics, baseline characteristics, and blood chemistry at baseline were documented, and descriptive statistical analyses were conducted.Seventy eight patients (33%) were treated with venetoclax monotherapy, 101 (42%) with venetoclax in combination with rituximab and 60 (25%) with venetoclax in combination with obinutuzumab. In all cases, the TLS risk mitigation strategy adhered to the ramp-up protocol. Median age was 73 years and 66% of patients were male. The majority of patients (75%) had relapsed/refractory CLL, 63/192 (32.8%) patients tested had a del(17p) and 93/134 (69.4%) patients tested had unmutated immunoglobulin heavy chain variable region gene (IGHV). Clinical TLS occurred in 5 patients (2.1%) and laboratory TLS occurred in 15 patients (6.3%). Ten patients received specific treatment, of which 6 were hospitalized. There were no deaths due to a TLS event and venetoclax was well-tolerated. Of the 5 clinical TLS events reported, none were fatal or resulted in renal failure (NCT03342144, registered on Nov 10, 2017).
Primary pulmonary myxoid sarcoma with EWSR1::CREB1 fusion: a literature review
Authors: Miao Xinyu , Chen Jing , Yang Lan , Lu Hongyang 
Published: February 2024

Abstract
Purpose
This review primarily aims to review the epidemiology, clinical characteristics, imaging, pathology, immunohistochemistry, diagnosis, differential diagnosis, treatment, and prognosis of Primary pulmonary myxoid sarcoma (PPMS) with EWS RNA binding protein 1::cAMP response element binding protein 1 (EWSR1::CREB1) fusion. It provides reference for the diagnosis and treatment of this disease.

Methods
Retrospectively collected the literature about PPMS with EWSR1::CREB1 fusion, its clinical, radiology, histology, molecular characteristics and current treatment strategies were collated and analyzed. This review provides a detailed differential diagnosis of the disease.

Results
PPMS is an exceptionally rare, low-grade malignant tumor of the lung. This tumor commonly infiltrates lung tissue and develops within bronchial passages. It is identified by a genetic rearrangement involving the EWSR1 gene and a distinct chromosomal translocation t(2; 22)(q33; q12). Variants include EWSR1::CREB1 fusion and EWS RNA binding protein 1::activating transcription factors (EWSR1::ATF1) fusion. PPMS with EWSR1::CREB1 fusion is more prevalent among middle-aged individuals and affects both sexes almost equally. Clinical symptoms are relatively non-specific, primarily including cough, hemoptysis, and weight loss. Most patients undergo surgery and experience a favorable prognosis. Further research is required to validate the effectiveness of alternative treatments for PPMS with EWSR1::CREB1 fusion.

Conclusion
EWSR1 rearrangement and EWSR1::CREB1 fusion are crucial genetic features of PPMS and serve as important diagnostic markers. Immunohistochemically, PPMS tests positive for EMA. In terms of treatment, surgery has been the primary approach in recent years. Therefore, the efficacy of other treatments still requires further investigation.
PREF-NET: a patient preference and experience study of lanreotide autogel administered in the home versus hospital setting among patients with gastroenteropancreatic neuroendocrine tumours in the UK
Authors: Khan Mohid S. , Cook Kathryn , Weickert Martin O. , Davies Louise , Pritchard D. Mark , Day Melissa , Shah Tahir , Hull Diana , Caplin Martyn , Back Melissa , Pommie Christelle , Higgs Kate 
Published: February 2024

Abstract
Purpose
PREF-NET reported patients’ experience of Somatuline® (lanreotide) Autogel® (LAN) administration at home and in hospital among patients with gastroenteropancreatic neuroendocrine tumours (GEP-NETs).

Methods
PREF-NET was a multicentre, cross-sectional study of UK adults (aged ≥ 18 years) with GEP-NETs receiving a stable dose of LAN, which comprised of (1) a quantitative online survey, and (2) qualitative semi-structured interviews conducted with a subgroup of survey respondents. The primary objective was the description of overall patient preference for home versus hospital administration of LAN. Secondary objectives included describing patient-reported opinions on the experience and associated preference for each administration setting, and the impact on healthcare utilisation, societal cost, activities of daily living and health-related quality of life (HRQoL).

Results
In the primary analysis (80 patients; mean age 63.9 years), 98.7% (95% confidence interval [CI]: 96.1–100.0) of patients preferred to receive LAN at home, compared with 1.3% (95% CI: 0.0–3.9) who preferred the hospital setting. Among participants, over half (60.3%) received their injection from a non-healthcare professional. Most patients (79.5% [95% CI: 70.5–88.4]) reported a positive effect on HRQoL after the switch from hospital to home administration. Qualitative interviews (20 patients; mean age 63.6 years) highlighted that patients preferred home administration because it improved overall convenience; saved time and costs; made them feel more comfortable and relaxed, and less stressed; and increased confidence in their ability to self-manage their treatment.

Conclusion
Almost all patients preferred to receive LAN treatment at home rather than in hospital with increased convenience and psychological benefits reported as key reasons for this preference.
Surgical and conservative treatment outcomes of medication-related osteonecrosis of the jaw located at tori: a retrospective study
Authors: Amin Hameda , Andersen Sanne Werner Moeller , Jensen Simon Storgård , Kofod Thomas 
Published: February 2024

Abstract
Purpose
Tori and exostoses are considered risk factors for the development of medication-related osteonecrosis of the jaw (MRONJ). The aims of this study were to present the prevalence of MRONJ located at tori in the Copenhagen ONJ Cohort, evaluate the surgical treatment of MRONJ located at tori and explore trauma to tori as an additional risk factor in patients on antiresorptive medication.

Methods
Data from a consecutive series of 506 patients with MRONJ (Copenhagen ONJ Cohort) were reviewed for the presence of tori and MRONJ located at tori. Demographic and medical data were analyzed, and healing outcomes and pain after the prophylactic removal of tori, surgical treatment of MRONJ located at tori, and conservative treatment of MRONJ located at tori were evaluated and compared using Fisher’s exact test.

Results
MRONJ located at tori was frequent and could be identified in 53% of the patients with tori, which accounts for a prevalence of 5.1% in the entire cohort. Of the 28 surgically treated patients, 27 (96.4%) healed uneventfully with no exposed bone after their first or second revision surgery. Fourteen (41.2%) patients with tori underwent therapeutic removal, eight (23.5%) underwent prophylactic removal, and six (17.6%) underwent both therapeutic and prophylactic removals. Two (33.3%) of the six conservatively treated patients healed spontaneously. Both treatment types resulted in a significant decrease in pain.

Conclusion
Prophylactic and therapeutic surgical removal of tori are reliable treatments and should be considered if a patient’s general health allows surgery.

Trial registration
The study was approved by the Regional Scientific Ethical Committee (H-6–2013-010) on November 20, 2013, and was retrospectively registered.
Relictithismia kimotsukiensis, a new genus and species of Thismiaceae from southern Japan with discussions on its phylogenetic relationship
Authors: Suetsugu Kenji , Nakamura Yasunori , Nakano Takafumi , Tagane Shuichiro 
Published: February 2024

AbstractThe family Thismiaceae, known as “fairy lanterns” for their urn- or bell-shaped flowers with basally fused tepals, consists of non-photosynthetic flowering monocots mainly in tropical regions, extending into subtropical and temperate areas. Here, we propose a new mycoheterotrophic genus, Relictithismia Suetsugu & Tagane (Thismiaceae), with its monotypic species Relictithismia kimotsukiensis Suetsugu, Yas.Nakam. & Tagane from Kimotsuki Mountains in the Osumi Peninsula, Kagoshima Prefecture, Kyushu Island, southern Japan. Relictithismia resembles Haplothismia Airy Shaw in having a cluster of tuberous roots, a feature previously observed only in this genus within the family Thismiaceae. However, it differs in having solitary flowers (vs. 2–6-flowered pseudo-raceme in Haplothismia), anther thecae largely separated (vs. connate), and the presence of an annulus (vs. absent). Additionally, Relictithismia differs from the geographically overlapping genus Thismia Griff. in its stamen structure and the position of the annulus. In Relictithismia, the stamens lack connectives, and its free filaments arise from the annulus located inside the perianth mouth, while in Thismia, the stamens typically have connate connectives, forming a staminal tube pendulous from the annulus located at the mouth of the floral tube. Our morphological and phylogenetic data indicated that R. kimotsukiensis holds an early-diverging position within the family, situated outside the Old World Thismia clade. This paper offers an extensive description and color photographs of R. kimotsukiensis, complemented by notes on its phylogenetic relationship and evolutionary history.
Chronic exercise and neuropsychological function in healthy young adults: a randomised controlled trial investigating a running intervention
Authors: Alexander Mhairi , Machado Liana 
Published: February 2024

AbstractDespite the well-known physical and mental health benefits of regular exercise, many of the world’s population, including healthy young adults, grossly undershoot recommended physical activity levels. Chronic exercise has potential to improve cognitive performance and affect in most age groups. However, there is currently a poverty of relevant research in young adults, especially randomised controlled trials. To address this, the current research investigated the effects of a running intervention on neuropsychological function (cognition and affect) in young adults. We predicted that following a running intervention, neuropsychological performance would improve alongside increases in aerobic fitness. Thirty-two healthy young adult university students were randomised (using a 3:1 ratio) into an intervention or control group, with the intervention group (n = 24) asked to run for 30 min three times a week over a 6-week period and the control group (n = 8) asked to maintain their current level of exercise over a 6-week period. We assessed fitness, cognitive performance, affect and running enjoyment at baseline and follow-up, and runners recorded the environmental conditions of their runs. Repeated measures ANCOVAs failed to find any significant effects of the running intervention on fitness or the neuropsychological measures. Anecdotal evidence supported running environment and enjoyment as potentially relevant factors. The failure to find any fitness improvements, which likely underpins the lack of neuropsychological improvements, highlights the importance of monitoring exercise sessions. Coupled with other insights gained from this trial, this article may prove useful towards future endeavours to develop exercise interventions beneficial to young adults.TRN: ACTRN12621000242820, Date of registration: 08/03/2021.
Muscle Morphology Does Not Solely Determine Knee Flexion Weakness After Anterior Cruciate Ligament Reconstruction with a Semitendinosus Tendon Graft: A Combined Experimental and Computational Modeling Study
Authors: Kositsky Adam , Stenroth Lauri , Barrett Rod S. , Korhonen Rami K. , Vertullo Christopher J. , Diamond Laura E. , Saxby David J. 
Published: February 2024

AbstractThe distal semitendinosus tendon is commonly harvested for anterior cruciate ligament reconstruction, inducing substantial morbidity at the knee. The aim of this study was to probe how morphological changes of the semitendinosus muscle after harvest of its distal tendon for anterior cruciate ligament reconstruction affects knee flexion strength and whether the knee flexor synergists can compensate for the knee flexion weakness. Ten participants 8–18 months after anterior cruciate ligament reconstruction with an ipsilateral distal semitendinosus tendon autograft performed isometric knee flexion strength testing (15°, 45°, 60°, and 90°; 0° = knee extension) positioned prone on an isokinetic dynamometer. Morphological parameters extracted from magnetic resonance images were used to inform a musculoskeletal model. Knee flexion moments estimated by the model were then compared with those measured experimentally at each knee angle position. A statistically significant between-leg difference in experimentally-measured maximal isometric strength was found at 60° and 90°, but not 15° or 45°, of knee flexion. The musculoskeletal model matched the between-leg differences observed in experimental knee flexion moments at 15° and 45° but did not well estimate between-leg differences with a more flexed knee, particularly at 90°. Further, the knee flexor synergists could not physiologically compensate for weakness in deep knee flexion. These results suggest additional factors other than knee flexor muscle morphology play a role in knee flexion weakness following anterior cruciate ligament reconstruction with a distal semitendinosus tendon graft and thus more work at neural and microscopic levels is required for informing treatment and rehabilitation in this demographic.
Frontiers and trends of supply chain optimization in the age of industry 4.0: an operations research perspective
Authors: Xu Zhitao , Elomri Adel , Baldacci Roberto , Kerbache Laoucine , Wu Zhenyong 
Published: February 2024

AbstractIndustrial 4.0 (I4.0) is believed to revolutionize supply chain (SC) management and the articles in this domain have experienced remarkable increments in recent years. However, the existing insights are scattered over different sub-topics and most of the existing review papers have ignored the underground decision-making process using OR methods. This paper aims to depict the current state of the art of the articles on SC optimization in I4.0 and identify the frontiers and limitations as well as the promising research avenue in this arena. In this study, the systematic literature review methodology combined with the content analysis is adopted to survey the literature between 2013 and 2022. It contributes to the literature by identifying the four OR innovations to typify the recent advances in SC optimization: new modeling conditions, new inputs, new decisions, and new algorithms. Furthermore, we recommend four promising research avenues in this interplay: (1) incorporating new decisions relevant to data-enabled SC decisions, (2) developing data-enabled modeling approaches, (3) preprocessing parameters, and (4) developing data-enabled algorithms. Scholars can take this investigation as a means to ignite collaborative research that tackles the emerging problems in business, whereas practitioners can glean a better understanding of how to employ their OR experts to support digital SC decision-making.
Development of a core outcome set for breast cancer-related lymphedema: a Delphi study
Authors: Doubblestein David , Koehler Linda , Anderson Elizabeth , Scheiman Nicole , Stewart Paula , Schaverien Mark , Armer Jane 
Published: February 2024

Abstract
Purpose
For breast cancer survivors (BCS) living with breast cancer-related lymphedema (BCRL), what outcome domains (OD) should be measured to assess the burden of the disease and efficacy of interventions? A Core Outcome Set (COS) that promotes standardized measurement of outcomes within the constraints of time influenced by work environments is essential for patients and the multidisciplinary professionals that manage and research BCRL.

Methods
Using Delphi methodology, a multidisciplinary group of BCRL experts (physical and occupational therapists, physicians, researchers, physical therapist assistants, nurses, and massage therapist) completed two waves of online surveys. BCRL expert respondents that completed the first survey (n = 78) had an average of 26.5 years in practice, whereas, respondents who completed the second survey (n = 33) had an average of 24.9 years. ODs were included in the COS when consensus thresholds, ranging from 70% to 80%, were met.

Results
A total of 12 ODs made up the COS. Reaching a minimum consensus of 70%; volume, tissue consistency, pain, patient-reported upper quadrant function, patient-reported health-related quality of life, and upper extremity activity and motor control were recommended at different phases of the BCRL continuum in a time-constrained environment. Joint function, flexibility, strength, sensation, mobility and balance, and fatigue met an 80% consensus to be added when time and resources were not constrained.

Conclusion
The COS developed in this study thoroughly captures the burden of BCRL. Using this COS may reduce selective reporting, inconsistency in clinical use, and variability of reporting across interdisciplinary healthcare fields, which manage or research BCRL.
Separate But Equal: Is Segregated Schooling (Still) Good for Girls?
Authors: Dustin Moira , Malleson Kate 
Published: February 2024

AbstractThe UK’s Equality legislation prohibits formal segregation with limited exemptions. Single-sex schools are one such exemption. No rationale for this was provided at the time of the legislation, and it was not until 2017 in the case of Al Hijrah that the question arose of whether and when sex-segregation in schools is lawful. We take up this question, reviewing the equality costs and benefits of sex-segregated schools conceptually and empirically. We highlight the incoherence of equality law regarding schools, and the limited evidence of their benefits. Drawing on feminist theory, we recommend improvements that may be useful in future cases where sex-segregation is contested in the context of faith-based schools. Lastly, we note that these legal questions may one day be challenged by a deeper source of instability if there is a breakdown in the binary sex categories on which sex-segregation in schools currently depends.
Paranoia and Data-Gathering Biases in Autism
Authors: Bennert Kristina , Brosnan Mark , Canning Amy , Roberts Ged , Russell Ailsa 
Published: February 2024

AbstractPrevious research has identified contradictory patterns in autism upon probabilistic reasoning tasks, and high levels of self-report paranoia symptoms have also been reported. To explore this relationship, the present study assessed 64 non-autistic and 39 autistic adults on two variants of a probabilistic reasoning task which examined the amount of evidence required before making a decision and ‘jumping to conclusions’ (a neutral beads task and an emotionally-salient words variant). The autism group was found to require significantly more evidence before making a decision and to have significantly less jumping to conclusions than the non-autistic group. For those with relatively low levels of paranoia, the emotionally-salient variant impacted on the non-autistic group, but not the autism group.
Towards a knowledge graph framework for ad hoc analysis in manufacturing
Authors: Meyers Bart , Vangheluwe Hans , Lietaert Pieter , Vanderhulst Geert , Van Noten Johan , Schaffers Michel , Maes Davy , Gadeyne Klaas 
Published: February 2024

AbstractThe development of artificial intelligence models for data driven decision making has a lot of potential for the manufacturing sector. Nevertheless, applications in industry are currently limited to the actionable insights one can discover from the available data and knowledge of a manufacturing system. We call the process to obtain such insights “ad hoc analysis”. Ad hoc analysis at system level is very complex in an industrial setting due to the inherent heterogeneity of data and existence of data silos, the lack of information and knowledge formalization, and the inability to meaningfully and efficiently reason about the data, information and knowledge. In this paper, we provide and outline a framework for ad hoc analysis in manufacturing based on knowledge graphs and influenced by the metamodelling paradigm. We derive its requirements and key elements from an analysis of several industry application cases. We show how manufacturing data, information and knowledge can be combined and made actionable using this framework. The framework supports workflows and tools for the data consumer (i.e., data scientist), and for the knowledge engineer. Furthermore, we show how the framework is integrated with existing data sources. Then, we discuss how we applied the framework to several application cases. We discuss how the framework contributes when applied, and what challenges still remain.