bluuebunny/crossref_metadata_2025_split huggingface dataset:
Automated algorithm aided capacity and confidence boost in surgical decision-making training for inferior clivus
Authors: Tang Ke , Bu Bo , Tian Hongcheng , Li Yang , Jiang Xingwang , Qian Zenghui , Zhou Yiqiang 
Published: April 2024

ObjectiveTo assess the impact of automated algorithms on the trainees’ decision-making capacity and confidence for individualized surgical planning.MethodsAt Chinese PLA General Hospital, trainees were enrolled to undergo decision-making capacity and confidence training through three alternative visual tasks of the inferior clivus model formed from an automated algorithm and given consecutively in three exemplars. The rationale of automated decision-making was used to instruct each trainee.ResultsFollowing automated decision-making calculation in 50 skull base models, we screened out three optimal plans, infra-tubercle approach (ITA), trans-tubercle approach (TTA), and supra-tubercle approach (STA) for 41 (82.00%), 8 (16.00%), and 1 (2.00%) subject, respectively. From September 1, 2023, through November 17, 2023, 62 trainees (median age [range]: 27 [26–28]; 28 [45.16%] female; 25 [40.32%] neurosurgeons) made a decision among the three plans for the three typical models (ITA, TTA, and STA exemplars). The confidence ratings had fine test-retest reliability (Spearman's rho: 0.979; 95% CI: 0.970 to 0.988) and criterion validity with time spent (Spearman's rho: −0.954; 95%CI: −0.963 to −0.945). Following instruction of automated decision-making, time spent (initial test: 24.02 vs. 7.13 in ITA; 30.24 vs. 7.06 in TTA; 34.21 vs. 12.82 in STA) and total hits (initial test: 30 vs. 16 in ITA; 37 vs. 17 in TTA; 42 vs. 28 in STA) reduced significantly; confidence ratings (initial test: 2 vs. 4 in ITA; 2 vs. 4 in TTA; 1 vs. 3 in STA) increased correspondingly. Statistically significant differences (P &lt; 0.05) were observed for the above comparisons.ConclusionsThe education tool generated by automated decision-making considers surgical freedom and injury risk for the individualized risk-benefit assessment, which may provide explicit information to increase trainees’ decision-making capacity and confidence.
Female Deer Movements Relative to Firearms Hunting in Northern Georgia, USA
Authors: Rosenberger Jacalyn P. , Edge Adam C. , Killmaster Charlie H. , Johannsen Kristina L. , Osborn David A. , Nibbelink Nathan P. , Miller Karl V. , D’Angelo Gino J. 
Published: April 2024

Perceived risk associated with hunters can cause white-tailed deer (Odocoileus virginianus) to shift their activity away from key foraging areas or alter normal movements, which are important considerations in managing hunting and its effects on a population. We studied the effects of seven firearms hunts on the movements of 20 female deer in two Wildlife Management Areas within the Chattahoochee National Forest of northern Georgia, USA, during the 2018–2019 and 2019–2020 hunting seasons. Deer populations and the number of hunters in our study area have declined significantly since the 1980s. In response, hunting regulations for the 2019–2020 hunting season eliminated opportunities for harvesting female deer. To evaluate the indirect effects of antlered deer hunting on non-target female deer, we calculated 90% utilization distributions (UDs), 50% UDs, and step lengths for pre-hunt, hunt, and post-hunt periods using the dynamic Brownian bridge movement model. Data included 30 min GPS locations for 44 deer-hunt combinations. Pre-hunt 50% UDs (x− = 7.0 ha, SE = 0.4 ha) were slightly greater than both hunt (x− = 6.0 ha, SE = 0.3 ha) and post-hunt (x− = 6.0 ha, SE = 0.2 ha) 50% UDs (F = 3.84, p = 0.03). We did not detect differences in step length, nor did we detect differences in size or composition of 90% UDs, among the periods. Overall, our results suggest that the low level of hunting pressure in our study area and lack of exposure to hunters led to no biologically significant changes in female deer movements. To the extent of the findings presented in this paper, adjustments to the management of hunting in our study area do not appear to be necessary to minimize hunting-related disturbances for female deer. However, managers should continue to consider female deer behavior when evaluating future changes to hunting regulations.
Curcumin Supplementation Improves Growth Performance and Anticoccidial Index by Improving the Antioxidant Capacity, Inhibiting Inflammatory Responses, and Maintaining Intestinal Barrier Function in Eimeria tenella-Infected Broilers
Authors: Chen Yan , Liu Liheng , Yu Longfei , Li Shuo , Zhu Nianhua , You Jinming 
Published: April 2024

This study was conducted to investigate the effects of dietary curcumin supplementation on growth performance, anticoccidial index, antioxidant capacity, intestinal inflammation, and cecum microbiota in broilers infected with Eimeria tenella. A total of 234 one-day-old broilers were categorized into three treatments, with six replicates per treatment containing 13 broilers each. The three treatments included the control group, Eimeria tenella group, and Eimeria tenella + curcumin (200 mg/kg) group. The feeding trial lasted for 42 days, during which the broilers were orally administered with 0.9% saline or 5 × 104 Eimeria tenella oocysts on day 14 of the study. On day 17 and day 21, one bird per replicate was selected for slaughtering. Results indicated an increased survival rate and anticoccidial index and improved productive performance in coccidia-infected broilers with curcumin supplementation. Furthermore, curcumin enhanced the serum antioxidant capacity in Eimeria tenella-infected broilers, evidenced by increased serum catalase activity (3d, 7d), as well as decreased malondialdehyde level (3d, 7d) and nitric oxide synthase activity (7d) (p < 0.05). Curcumin also improved intestinal inflammation and barrier function, evidenced by the downregulation of interleukin (IL)-1β (3d, 7d), TNF-alpha (TNF-α) (3d, 7d), and IL-2 (7d) and the up-regulated mRNA levels of claudin-1 (7d), zonula occludens (ZO-1; 3d, 7d), and occludin (3d, 7d) in the ceca of infected broilers (p < 0.05). Eimeria tenella infection significantly disrupted cecum microbial balance, but curcumin did not alleviate cecum microbial disorder in broilers infected with Eimeria tenella. Collectively, curcumin supplementation enhanced growth performance and anticoccidial index in Eimeria tenella-infected broilers via improving antioxidant ability and cecum inflammation without affecting cecum microbiota.
NCI 159456 PERK Inhibitor as a Targeted Therapy for Lung Cancer: An In Vitro Study
Authors: Rozpędek-Kamińska Wioletta , Galita Grzegorz , Siwecka Natalia , Granek Zuzanna , Barczuk Julia , Saramowicz Kamil , Majsterek Ireneusz 
Published: April 2024

Non-small cell lung cancer (NSCLC) represents the most common histological type of lung cancer, characterized by a five-year survival rate of 15% and poor prognosis. Accumulating evidence indicates a prominent role of endoplasmic reticulum (ER) stress and the protein kinase RNA-like ER kinase (PERK)-dependent pathway of the unfolded protein response (UPR) in the pathogenesis of NSCLC. Increased expression of downstream targets of PERK was observed in various subtypes of NSCLC, and it was associated with a more aggressive phenotype, high risk of recurrence, and poor prognosis. Therefore, the present study aimed to investigate the biological effect of the selective PERK inhibitor NCI 159456 on A549 NSCLC cells and Human Pulmonary Fibroblasts (HPF) in vitro. Treatment of both normal and ER-stressed A549 cells with NCI 159456 resulted in a significant increase in the mRNA expression level of pro-apoptotic genes like activating transcription factor 4 (ATF4), DNA damage inducible transcript 3 (DDIT3), and BCL2 Associated X, Apoptosis Regulator (BAX) as well as a decreased level of the anti-apoptotic gene B-cell lymphoma 2 (Bcl-2). Cytotoxicity and genotoxicity analyses revealed that NCI 159456 significantly decreased viability and increased DNA damage in A549 cells under normal and ER stress conditions. Caspase-3 and reactive oxygen species (ROS) detection assays demonstrated that NCI 159456 significantly induced apoptosis and increased the ROS level in normal and ER-stressed A549 cells. Importantly, treatment with the inhibitor did not affect substantially normal HPF cells at any used concentration. The results indicate that PERK inhibitors could potentially be applied as a targeted therapy for NSCLC.
Transcriptome Analysis Provides Insights into Water Immersion Promoting the Decocooning of Osmia excavata Alfken
Authors: Wang Guiping , Wang Guangzhao , Li Jiale , Ma Yixiang , You Yinwei , Zhou Zizhang , Zhao Yunhe , Men Xingyuan , Song Yingying , Yu Yi 
Published: April 2024

The timing of decocooning and nesting during the flowering period are crucial for the reproduction and pollination activities of Osmia excavata. In order to improve the pollination efficiency of O. excavata, it is crucial to find a way to break the cocoon quickly. Our results showed that the decocooning rates at 6, 12, 24, 36, 48, and 72 h after 30 min of water immersion (WI) were 28.67%, 37.33%, 37.33%, 41.33%, 44.33%, and 53.00%, respectively. The decocooning rate fold of 6 h was 14.33 compared with the control group. Transcriptome sequencing resulted in 273 differentially expressed genes (DEGs) being identified between the WI and control groups. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis showed that muscle-related functions play important roles in O. excavata decocooning in response to WI. Cluster analysis also showed that DEGs in cardiac muscle contraction and adrenergic signaling in cardiomyocytes were up-regulated in response to WI-promoted decocooning. In conclusion, the rate of decocooning can be improved by WI in a short time. During WI-promoted decocooning, muscle-related pathways play an important role. Therefore, the application of this technology will improve the pollination effect of O. excavata.
Genomic Characterization of Listeria monocytogenes and Other Listeria Species Isolated from Sea Turtles
Authors: Di Renzo Ludovica , De Angelis Maria Elisabetta , Torresi Marina , Mariani Giulia , Pizzurro Federica , Mincarelli Luana Fiorella , Esposito Emanuele , Oliviero Maria , Iaccarino Doriana , Di Nocera Fabio , Paduano Gianluigi , Lucifora Giuseppe , Cammà Cesare , Ferri Nicola , Pomilio Francesco 
Published: April 2024

Listeria monocytogenes is a ubiquitous pathogen found both in the environment and food. It can cause listeriosis in a wide range of animals as well as in humans. Investigations on presence, spread and virulence are still limited to terrestrial and human environments. Embracing the One Health Approach, investigating the presence and spread of L. monocytogenes in marine ecosystems and among wildlife, would provide us with useful information for human health. This study investigated the presence of L. monocytogenes and Listeria spp. in two species of sea turtles common in the Mediterranean Sea (Caretta caretta and Chelonia mydas). A total of one hundred and sixty-four carcasses of sea turtles (C. caretta n = 161 and C. mydas n = 3) stranded along the Abruzzo, Molise, Campania, and Calabria coasts, were collected. Brain and fecal samples were taken, enriched, and cultured for the detection of Listeria spp. From the specimens collected, strains of L. monocytogenes (brain n = 1, brain and feces n = 1, multiorgan n = 1 and feces n = 1), L. innocua (feces n = 1 and brain n = 1), and L. ivanovii (brain n = 1) were isolated. Typical colonies were isolated for Whole Genome Sequencing (WGS). Virulence genes, disinfectants/metal resistance, and antimicrobial resistance were also investigated. L. monocytogenes, L. innocua, and L. ivanovii were detected in C. caretta, whilst only L. monocytogenes and L. innocua in C. mydas. Notable among the results is the lack of significant differences in gene distribution between human and sea turtle strains. Furthermore, potentially pathogenic strains of L. monocytogenes were found in sea turtles.
Online learning for allied health knowledge translation: A systematic review
Authors: Joy Anna , Carey Leeanne , Neilson Cheryl , Lockwood Kylee , Harding Katherine 
Published: April 2024

Purpose: To synthesise evidence on the effectiveness of online learning platforms for facilitating knowledge translation in allied health professionals.
Methodology: A systematic review of the literature searched three databases (Medline-OVID, CINAHL, Embase) in November 2023 for studies measuring outcomes of knowledge translation initiatives targeting allied health professionals delivered using online learning platforms. Papers were eligible if allied health professionals made up at least 50% of the sample, most of the learning component was online, and comparative data was reported. Data were extracted using a customised form. Quality of studies was appraised using the Downs and Black checklist. Meta-analyses were conducted where sufficient homogenous data were available.
Findings: Twenty-three studies published over a 13-year period were included in this review primarily using pre-post study designs. All reported improvements in either knowledge, skill and/or confidence, with an meta-analysis (n=9 studies) showing a significant increase in knowledge gain after exposure to online learning (SMD 1.39; 95% CI = 0.96-1.83). However, there is little evidence that participation in online learning is associated with a change in clinical practice.
Research Implications: This study supports previous research that online learning can improve knowledge but highlights a need for more rigorous studies addressing the impacts on behaviour change.
Practical Implications: Online learning is an effective way of improving knowledge, skill and/or confidence but additional knowledge translation strategies may be needed to lead to a behaviour change.
Originality/Value: Synthesis of current knowledge of the value and limitations of online learning as a tool to facilitate the implementation of evidence into practice in the allied health professions.
Limitations: This review was limited to studies published in the English language only. The quality of studies in this field is low. Few studies measure behaviour change.
Health Determinants of Methylmercury Exposure in Coastal Pakistani Women: Fish Consumption and Environmental Influences
Authors: Ali Khan Asad , Syed Iqbal Azam  
Published: April 2024

Background: Mercury pollution from industries poses health risks through bioaccumulation in fish. Women in coastal communities with high fish intakes are particularly vulnerable. However, methylmercury (MeHg) exposure has not been quantified in Pakistan.
Objective: To estimate MeHg levels in the scalp hair of women from a coastal community in Sindh province and examine the relationship with fish consumption and other risk factors.
Methods: A cross-sectional study was conducted among 100 women aged 15–49 years in Rehri Goth, Sindh. Detailed dietary histories were obtained through interviews. Scalp hair samples were analysed for total mercury using cold-vapour Vapor Atomic Absorption Spectrophotometry.
Results: The median hair MeHg level was 7.15 μg/g, exceeding international guidelines. Higher levels were associated with fish from polluted waters (3.5 μg/g), skin whitening product use (6.5 μg/g), and traditional medicine intake (9.0 μg/g). A weak positive correlation was found between MeHg and age. Fish consumption averaged 4 times/week.
Conclusion: Women in coastal Sindh have high MeHg exposure from frequent fish intake, likely exacerbated by industrial pollution. Risk mitigation is needed to protect vulnerable populations, especially during critical windows of neurodevelopment.
Radon levels in three fish rearing buildings at Cleghorn Springs State Fish Hatchery, Rapid City, South Dakota, USA
Authors: Gerber Alexis L. , Martling Shaylee , Voorhees Jill M. , Marchant Hope , Barnes Michael E. 
Published: April 2024

Fish hatchery workers may be exposed to potentially health-threatening radon gas liberated from ground water used during fish rearing. This study surveyed the radon levels in three fish rearing buildings (small tankroom, tankroom, and rearing pavilion) at Cleghorn Springs State Fish Hatchery, Rapid City, South Dakota, USA. Overall radon values ranged from below the detection limit in all three buildings to a high of 2,317.68 Bq/m3 (62.64 pCi/L) in the tankroom. The pavilion had the lowest mean ± SE value of 56.57 ± 40.71 Bq/m3 (1.23 ± 0.11 pCi/L), while the highest mean value of 796.21 ± 54.61 Bq/m3 (23.67 ± 1.34 pCi/L) was in the small tankroom. Maximum radon levels were 1,231.36, 2,317.68, and 365.93 Bq/m3 (33.28, 62.64, and 9.89 pCi/L) in the small tankroom, tankroom, and pavilion, respectively. Radon levels were significantly correlated with the number of tanks receiving water in both the small tankroom and tankroom, but no such correlation was observed in the relatively open-air pavilion. Even though the water at the hatchery was aerated outside, additional aeration from rearing tank spray bars inside the enclosed small tankroom and tankroom resulted in relatively high radon levels.
Characteristics of highly sensitive hydrogen gas sensor based on Pt-SiO2/Si microring resonator
Authors: Igarashi Junpei , Okazaki Shinji , Nishijima Yoshiaki , Higo Akio , Arakawa Taro 
Published: April 2024

Abstract
A hydrogen gas sensor based on a silicon microring resonator (MRR) with a Pt–SiO2 thin film as a hydrogen-sensitive film is proposed and investigated to realize a high-sensitivity hydrogen sensor. The sensor detects hydrogen on the basis of the resonant wavelength shift caused by the reaction heat generated in the Pt–SiO2 film. In the hydrogen exposure measurement, resonant wavelength shifts of approximately 5.0 and 2.4 nm were observed at hydrogen concentrations of 4.0 and 0.4 vol%, respectively, showing the high sensitivity of the proposed sensor. In addition, an MRR sensor with an upper Al2O3 cladding layer is proposed and its higher sensitivity is theoretically demonstrated.
Cyrylickie stare druki Ewangelii tetr wydane w Kijowie w 1697 i 1712 roku – ich tradycja liturgiczna i oryginał. Analiza świętych i świąt obecnych w menologionach
Authors: Ostapczuk Jerzy 
Published: April 2024

Dziesięć cyrylickich starych druków liturgicznych Ewangelii tetr wydanych przez Drukarnię Ławry Kijowsko-Peczerskiej można podzielić na dwie grupy. Jedną z nich stanowią dwie wyjątkowe edycje z 1697 i 1712 roku. Te dwie kijowskie Ewangelie ukazały się po aneksji w 1686 roku metropolii kijowskiej przez patriarchat moskiewski. Wydarzenie to skutkowało stopniową utratą tożsamości przez kijowską tradycję liturgiczną i wprowadzeniem w 1720 roku cenzury władz moskiewskich nad drukarniami w Kijowie i Czernihowie. Analiza tekstologiczna kilku fragmentów Ewangelii tetr i paratekstów (tj. Przedmowy do Ewangelii i tytułów ewangelijnych) wskazała, że pierwsze dwie kijowskie Ewangelie, oprócz typowych tylko im wariantów tekstu, zawierają również warianty poświadczone wyłącznie w moskiewskich Ewangeliach tetr z II połowy XVII wieku. Menologiony, które w starych drukach Ewangelii tetr były zawsze umieszczane na końcu, zawierają niekiedy świętych i święta czczonych tylko lokalnie. Wspomnienia te są pomocne w poszukiwaniu oryginałów zarówno drukowanych, jak i pisanych ręcznie Ewangelii. Menologiony przekazują również pewne informacje o lokalnej tradycji liturgicznej. Niniejsza publikacja koncentruje się na wariantach tekstu i tradycji liturgicznej odzwierciedlonej w menologionach cyrylickich starych druków Ewangelii tetr. Były one podstawą do wskazania oryginału pierwszych dwóch kijowskich edycji Ewangelii, tj. moskiewskiego wydania z 1688 roku. Udowodniono również, że te dwie Ewangelie wydrukowane w Kijowie w latach 1697 i 1712 zawierają wspomnienia niektórych lokalnie czczonych świętych, pominiętych nie tylko we wszystkich kolejnych kijowskich edycjach, ale również we wszystkich innych 108 poddanych analizie Ewangeliach tetr.
Geneza nauki konfirmacyjnej jako formy kształcenia konfesyjnego w tradycji protestanckiej
Authors: Byrtek Elżbieta 
Published: April 2024

W Kościołach ewangelickich zajęcia konfirmacyjne są traktowane jako uzupełnienie edukacji religijnej prowadzonej w szkole. Szkolna edukacja religijna ma charakter dialogiczny i jest elementem edukacji ogólnej. Kościoły tradycji reformacyjnej prowadzą dodatkową formę edukacji konfesyjnej, jaką są zajęcia konfirmacyjne. W Polsce – ze względu na diasporalny charakter Kościoła luterańskiego i reformowanego – zajęcia konfirmacyjne są zintegrowane z nauką religii. Tym niemniej są one rozbudowane o dodatkowe aktywności. W niniejszym artykule przedstawiam genezę zajęć konfirmacyjnych jako aktu religijnego i pedagogicznego. Analizy historyczne mają istotne znaczenie dla współczesnego rozumienia edukacji religijnej. Potwierdzają, że jest możliwy balans między edukacją religijną w szkole a formacją konfesyjną.
Król jako pasterz w tekstach królewskich okresu starobabilońskiego (XX–XVII w. przed Chr.)
Authors: Tyborowski Witold 
Published: April 2024

Mimo postępu nauki, zwłaszcza w kręgach nie-specjalistów, utrzymuje się tendencja do interpretowania różnych zjawisk z kręgu kultur starożytnego Bliskiego Wschodu przez pryzmat tradycji opartej na Biblii. Jednym z nich jest symbol króla-pasterza ukazywany jako troskliwy opiekun i przewodnik swego ludu. Tak właśnie są ukazywane i interpretowane najważniejsze postaci z dziejów i tradycji starożytnego Izraela od Abrahama do Jezusa, który należy już do nowej, chrześcijańskiej tradycji. Także w Mezopotamii liczni przywódcy, tj. królowie określani są jako pasterze. Co istotne, to oni sami nazywają tak siebie samych w swych dość licznych inskrypcjach. Jest to szczególnie widoczne w okresie starobabilońskim, z którego pochodzi 75 takich odniesień. Występuje tam w 30 rozbudowanych tytułach nawiązujących do symbolu króla-pasterza. Z pozoru stanowią one klarowną paralelę do zjawiska, które spotykamy w Biblii. Jednakże analiza tych tytułów w tekstach królewskich tego okresu pokazuje, że król nie jest tam ukazywany jako troskliwy opiekun swojego ludu, lecz sługa bóstw, zasadniczo skupiony na zaspokajaniu ich potrzeb. Wątek opiekuńczości króla-pasterza wobec poddanych jest w tym okresie zdecydowanie drugorzędny i to nie on definiuje podstawowe znaczenie tego symbolu. Król-pasterz jest wówczas bardziej hodowcą zwierząt ofiarnych niż ich opiekunem. Wniosek ten potwierdza ikonografia, jaką znajdujemy na starobabilońskich pieczęciach cylindrycznych. Tak więc, w tym przypadku istnieje wyraźna różnica w tym, jak należy rozumieć ten symbol w tradycji biblijnej i mezopotamskiej.
Митрополит Антоний (Храповицкий) и идея государственности Украины в период правления гетмана Павла Скоропадского
Authors: Шумило Виталий 
Published: April 2024

Цель публикации – на исторических материалах, которые ранее выпадали из поля зрения исследователей, рассмотреть историю взаимоотношений предстоятеля Православной Церкви в Украине Митрополита Киевского и Галицкого Антония (Храповицкого) и главы Украинской Державы Гетмана Павла Скоропадского. Устоявшаяся в украинской историографии мифологема о враждебности митрополита Антония (Храповицкого) украинской идее и украинской государственности и, как следствие, – конфронтации Митрополита с Гетманом П. Скоропадским – ошибочна. Митрополит Антоний с первых дней возглавления Православной Церкви в Украине занял позицию активной и искренней поддержки политики Гетмана в вопросе украинского государственного строительства. Из поначалу подозрительных их отношения постепенно переросли в уважительные и доверительные, поскольку митрополит Антоний был убежденным идейным сторонником и помощником Гетмана в его державной политике. Свержение Гетманата объединенными силами украинских социалистов, анархистов и российских большевиков привело к падению Украинской Державы и направило исторический ход церковных и государственных событий в иное русло, ввергнув Украину в хаос гражданской войны и советской оккупации, остановив развитие державного строительства в Украине на несколько десятков лет и изменив историю Украинской Церкви.