bluuebunny/crossref_metadata_2025_split huggingface dataset:
Status of Platelets in Complicated and Uncomplicated Diabetes Mellitus
Authors: Malhotra K.C. , Arya R.K. , Chugh S.N. , Singla B.B. 
Published: November 2007

Thirty patients with diabetes mellitus of more than 5 years' duration, divided into 2 groups of 15 each depending on the presence or absence of vascular complications, constituted the case material for the study. Fifteen healthy subjects of the same age group and sex served as controls. The platelet count and morphology were normal in controls as well as in patients with diabetes mellitus. The platelet adhesiveness increased signifi cantly with the increase in age and duration of diabetes and in the presence of vascular complications, irrespective of their type. The platelet aggregation time decreased with the increase in age as well as in diabetic patients with vascular complications, but the duration did not have any effect on it. The subject's sex, severity, and adequate control of diabetes mellitus with any type of therapy did not have any influence on the platelet functions studied.
Human Amnion in the Management of Chronic Ulceration of the Lower Limb: A Clinico-Pathologic Study
Authors: Egan T.J. , O'Driscoll J. , Thakar D.R. 
Published: November 2007

This study shows that unmodified human amnion can make a useful con tribution to the management of venous ulceration. By suppressing infection, and, by providing a healthy granulating surface, it significantly reduces the pre-skin graft preparation time, when compared with a conventional method of treatment. However, it does not seem to significantly influence the prospects of graft take, or of long term graft survival, in this comparison. A reversion towards normal of local vasculature, as characterized by vessel wall thinning and widening of the lumen, appears to be a significant tissue change induced by amnion treatment. Such a change may have considerable relevance in any analysis of the basis of the therapeutic efficacy of amnion.
Coronary Arteriographic Findings During Early Hours of Acute Myocardial Infarction: Response to Intracoronary Injection of Nitrates
Authors: Omote Shingo , Yasue Hirofumi , Takizawa Akinori , Nagao Masao , Hyon Hiromitsu , Nishida Shinichiro , Horie Minoru 
Published: November 2007

We performed coronary arteriography and gave intracoronary injection of nitrates within 8 hours after the onset of symptoms of acute myocardial infarction in eighteen patients. Improved distal filling or patency of the total occluded coronary artery after intracoronary injection of nitrates occurred in 4 of 18 patients. In one of four patients the first intracoronary nitrates injection failed to release the initial total occlusion, but after intracoronary Urokinase administration, the second nitrates injection succeeded to dilate the com pletely occluded coronary artery. Coronary arteriography was again per formed in sixteen patients in the chronic stage (4-15 weeks after the onset of acute myocardial infarction) and ergonovine malaete was injected intraven ously in seven patients. Focal spasm was induced by ergonovine injection in three patients in one of whom intracoronary nitrates failed to release the complete obstruction in the acute stage. We conclude that coronary spasm as well as intracoronary thrombosis plays an important role in the production of acute myocardial infarction.
Post Embolectomy Thrombosis Treated with Intra-Arterial Streptokinase
Authors: vonRyll Gryska P. , Raker Edmond J. 
Published: November 2007

A case is presented which demonstrates the occasional need for selective intra- arterial streptokinase when re-thrombosis has occurred following catheter thromboem bolectomy of a peripheral artery. It is recommended that repeat embolectomy be carried out and all mechanical causes for re-thrombosis be excluded before resorting to fi brinolysis. The literature citing other indications for selective arterial use of streptokinase is reviewed.
Fibrinolytic Therapy Urokinase for Myocardial Infarction
Authors: Nakano Minoru 
Published: November 2007

In recent years, the incidence of myocardial infarction has increased re markably in Japan, possibly because life styles have become westernized. Coronary care units have been established in many institutions, and various therapeutic modalities combining different drugs and surgical procedures are being used in the treatment of coronary artery disease with fairly good results. However, such medical treatment involves only preventive therapy against the progression of coronary arteriosclerosis or symptomatic therapy for myocar dial infarction. As for positive therapy, only the thrombolytic method using urokinase (UK) is considered to be therapeutically justified or effective. UK is believed to lyse thrombi appearing in the coronary artery and to prevent the extension of infarct by inhibiting the occurrence of secondary thrombi. The author has reported the results of previous studies using UK for treatment of myocardial infarction.1-3 In the present study, UK was adminis tered to patients with myocardial infarction who went coronary angiography.
Hypertensive Crisis Induced by Metoclopramide in Patient with Pheochromocytoma
Authors: Abe Masayoshi , Orita Yasuhiko , Nakashima Yasuhide , Nakamura Motoomi 
Published: November 2007

A hypertensive crisis associated with evidence of catecholamine release was induced following intravenous administration of 10 mg metoclopramide in a woman with pheochromocytoma and in whom the tyramine test was nega tive. After removal of the tumor, blood-pressure and plasma catecholamine concentrations were not influenced by the administration of metoclopramide. It is suggested that the mechanism of hypertensive crises induced by metoclo pramide may not be due to a direct catecholamine releasing effect from the tumor or sympathetic nerve endings, but rather to its presynaptic dopaminer gic blocking effect which would indirectly release catecholamines.
Femoro-Popliteal Bypass Simplified
Authors: Halsted George O. 
Published: November 2007

There is increasing emphasis on carrying femoro-popliteal bypass grafts below the knee and most vascular surgeons agree that reversed saphenous vein makes the best graft. However, some other considerations have become important and deserve consideration. P.T.F.E. grafts in this location have almost as good a long term patency rate as autologous vein grafts. Some very experienced vascular surgeons have indicated their preference for this type of graft, citing some of these pertinent reasons: Peripheral vascular disease usually is associated with lesions in other vessels. Since coronary artery bypass has become so commonly used to stave off myocardial infarction some thought should be given to preservation of suitable saphenous veins for this purpose. Harvesting the saphenous vein adds additional surgical trauma, time, exposure to sepsis, lymphatic interruption and extra incisions. Once we opt for preferential P.T.F.E. grafts, then we start to search for a simpler technique.
Effect of Hypocalcemia on Isoproterenol Induced Cardiotoxicity in Dogs
Authors: Darsinos John Th. , Karli Joan N. , Stathaki Stamatina N. , Ziroyannis Panayotis N. , Pistevos Anastasios C. , Levis Gabriel M. , Moulopoulos Spyridon D. 
Published: November 2007

The effect of serum calcium on the myocardial damages produced by isoproterenol was studied in the dog. Hemodialysis for 80 min in the absence of calcium was used to alter serum calcium concentration in seven experimental animals. The same number of animals were dialysed in the presence of calcium and were used as controls. After hemodialysis all animals were infused with isoproterenol 2.0 μg/kg/min for 4 hours. The myocardial damage was assessed by comparing serial measurements of the serum cardiac enzyme activities CK and CK-MB and the electrocardiographic findings of the two groups, before, during and after isoproterenol infusion. Serum calcium decreased significantly after dialysis only in the experimental group (1.15 vs 2.19 mmolL-1). Total C K activities of the experimental group during and after isoproterenol infusion were 2 to 3 times lower than in the controls (190-360 vs 410-1370 IU.L-1). Changes of the C K-MB isoenzyme activities were more profound, these were detectable and measured only in 4 of the experimental animals and in much lower activities than in the controls (25-61 vs 45-445 IU.L-1). A positive correlation was found (r=0.673, p<0.05) between the highest value of C K-MB of both groups and the serum calcium concentration after hemodialysis. In accordance to the differences of the biochemical estimates the effect of serum calcium on the cardiotoxic effect of isoproterenol has been further emphasized by the electrocardiographic findings. Thus arrhythmias, negative T-waves and significant ST segment depression were observed only in one experimental animal. In contrast these electrocardiographic disturbances were common and marked findings in all but one of the control animals. In both groups these electrocardiographic findings were reversed one to three hours after the termination of the isoproterenol infusion. Myocardial calcium at the end of the experiment was lower in the experimentals compared to the controls (0.23 vs 0.30 mmol.kg-1 wet weight). On the contrary magnesium concentration increased respectively. It is concluded that low serum calcium has a protective effect against the cardiotoxic action of isoproterenol. This protective action may be relevant to the decreased calcium and increased magnesium of the heart of the animals hemodialysed in the absence of calcium.
Abnormal Reflex Vasoconstriction to Cold Stimulation in Forearm of Patients with Variant Angina
Authors: Nakamura Yukio , Ikeda Takayuki , Takada Shigeo , Yamamoto Masakazu , Horikawa Kiyohiro , Kitamura Takashi , Kubota Kooji , Hattori Nobu 
Published: November 2007

The responses of the blood vessels of the forearm to cold pressor test and mental stress were examined in patients with variant angina and in control subjects. In response to cold pressor test, blood pressure, heart rate and forearm vascular resistance increased with statistical significance in both groups. Percentage changes in blood pressure and heart rate were not significantly different in patients and control ubjects. Percentage change in forearm vascular resistance in patients with variant ngina (120±101%) was significantly greater (p<0.05) than that in control subjects 47±26%). In response to mental stress, percentage change in forearm vascular resistence was -20±19% in patients with variant angina and -24±18% in control subjects and there was no significant difference in the two groups. We conclude that, in some patients with variant angina, not only the coronary artery but the forearm vessels show the abnormal reflex vasoconstriction and it may be ostulated that it represents the generalized abnormality of vascular smooth muscle or of their neural control which exists in some patients with variant angina.
Noninvasive Methods in the Diagnosis of Extracranial Carotid Artery Disease: A Correlation with Carotid Arteriography in Eighty Patients
Authors: Ramesh Adiga K. , Fresso Susan J. , Nayden John 
Published: November 2007

Five hundred fifty-nine patients were evaluted for carotid artery disease in the Blood Flow Laboratory by the following direct and indirect noninvasive methods: 1. Periorbital doppler examination; 2. Ocular pneumoplethysmography (Gee); 3. Pulsed doppler ultrasonic arteriography; and 4. Sound spectral analysis with a pulsed doppler. Carotid arteriograms were available for comparison with one hundred fifty- seven vessels (80 patients). Sensitivity, specificity and overall accuracy was established for each noninvasive modality by correlation with the angiographic findings. For detection of stenoses greater than 50% by diameter reduction, sensitivity was 98%. Sound spectral analysis and ultrasonic arteriography were found to yield a higher sensitivity when compared to the other noninvasive methods in detecting stenoses of less than 50%. In our hands, disturbed spectral flow patterns do not always correlate with the degree of stenosis in non-hemodynamic lesions. Our results indicate that proper patient selection for angiographic examina tion can be made through noninvasive screening.
Buflomedil in Arterial Occlusive Disease: Results of a Controlled Multicenter Study
Authors: Trübestein G. , Balzer K. , Bisler H. , Klüken N. , Muller-Wiefel H. , Unkel B. , Mahfoud Y. , Ziegler W. 
Published: November 2007

In a double-blind, randomised multicentre study buflomedil, a vasoactive substance, was compared with placebo in the treatment of 93 patients with chronic arterial occlusive disease. After a run-in period of four weeks the patients received either buflomedil (600 mg daily) or placebo over 12 weeks. The pain-free and the total walking distances improved significantly in both groups. However, the differences in the improvement between the two groups were highly signifi cant and in favour of buflomedil: for the pain-free walking distance p<0.001 and for the total walking distance p<0.01. The results indicate that buflomedil has a beneficial effect on the symptoms and lengthens the walking distance in patients with arterial occlusive disease.
Hypertension in the Elderly
Authors: Coodley Eugene L. 
Published: November 2007

Hypertension in the older population has a serious prognosis and this is true even for isolated systolic hypertension. There is a markedly increased risk of stroke, cardiovascular disease and central nervous system in such patients. The hemodynamics in hypertension of the elderly differs in a number of parameters from hypertension in the younger patient. In addition, drug metabolism is markedly altered by the aging process. This combination of factors requires a selective choice of agents for the management of hypertension in the elderly. The role of various drug modalities and their efficacy is reviewed in this presentation.
Main Systolic Blood Flow Patterns in the Left and Right Ventricular Outflow Tracts Determined by Doppler Echocardiography
Authors: Itoh Kouichi 
Published: November 2007

The main blood flow velocity patterns in the LVOT and RVOT were re corded by pulsed Doppler echocardiography in 28 normal healthy cases, in two athletes, and in 85 patients with atrial septal defects, pulmonary regurgitation, tetralogy of Fallot, aortic regurgitation, mitral stenosis, aortic stenosis, mitral regurgitation, hypertrophic cardiomyopathy, ischemic heart disease, and pul monary hypertension. Blood flow velocities were displayed using a graphic sys tem to form a real time sonogram, using Fast Fourier Transformation. In the normal group, the blood flow velocity was 1.69 KHz in LVOT, and 1.71 KHz in RVOT. In AR and T/F but not MS, there was high blood flow velocity in the LVOT, and the peak of blood flow velocity was shifted to mid-to late systole. In ASD and VSD with a L-R shunt, high blood flow velocity occurred in the RVOT, and the peak velocity shifted to eary systole. Pulmonary hypertension occa sionaly produced a W- or V-shaped curve. In normal subjects, a small "a" wave could be detected in the LVOT record ing. The "a" wave began at point B on the AML tracer of the M-mode echocar diography, reached maximum velocity at point C, and returned to zero (baseline) at point C'. The "a" wave was coincident with the R wave of the ECG, and with the Ia of the phonocardiogram (PCG). The normal velocity of the "a" wave was 602 Hz, and the a/H ratio was 0.36. In cases of HCM and IHD, the "a" wave velocity and the a/H ratio correlated with the end diastolic pressure and the peak dP/dT. These data suggest that the Doppler blood flow patterns in the LVOT and RVOT can indicate volume overload in the right and left ventricles, and that the "a" wave velocity and a/H ratio can provide new information concerning car diac performance.
Captopril for the Treatment of Patients with Hypertension and Peripheral Vascular Disease
Authors: Catalano M. , Libretti A. 
Published: November 2007

Many epidemiological studies have shown up the frequent association of ar terial hypertension (HT) with atherosclerosis of different localizations. How ever, many of the drugs used to treat HT are contraindicated in patients with peripheral vascular disease (PVD), because they cause unfavorable metabolic changes or vasoconstriction. The aim of the present study was to assess the effect of a proven hypotensive drug, captopril, on the peripheral circulation. The drug appeared to be effec tive in improving blood flow to lower limbs, prolonging the pain. Free interval and increasing the angle/arm arteral pressure index.
Spontaneous Major Intra-Abdominal Arteriovenous Fistulas: A Report of Several Cases
Authors: Astarita Denis , Filippone Dennis R. , Cohn Joseph D. 
Published: November 2007

Most major intra-abdominal fistulas result from trauma or surgery. Sponta neous fistulas are rare with less than 100 reported cases since 1831. From a review of hospital records, five such spontaneous fistulas were identified among 215 cases of abdominal aortic aneurysm between 1975 and 1983. These cases are presented and supplemented by 73 similar cases collected from a literature re view for discussion of the salient features of clinical presentation and manage ment of spontaneous major fistulas. Major intra-abdominal arteriovenous fistulas usually present with a machin ery bruit over a pulsatile mass, but may present more subtly with pain and otherwise unexplained hematuria. Because these fistulas lead to refractory heart failure, surgery should be expeditious. Closure should be performed from within the aneurysm with arterial and pulmonary artery pressure monitoring. Care must be taken to prevent pulmonary embolization.
Validity of Out-Patient Screening in Arteriosclerosis to Identify Multiple Lesions
Authors: Catalano Maria , Libretti Arnaldo 
Published: November 2007

A total of 594 patients admitted for cerebrovascular disease (CVD) and for peripheral vascular disease (PVD), were examined in a study aimed at clarify ing by a simple, inexpensive out-patient method, a) the relationship existing between the different locations of the vascular disease: brain, lower limbs, coro naries ; b) the prevalence in the patients studied of risk factors such as hyperten sion, hyperlipidaemia and diabetes, and of migraine. The results were as follows: a) of the patients admitted for CVD, 44% also presented arteriosclerosis in other locations; this figure was 32% for PVD cases; b) hypertension was found in 38.5% of CVD and 27% of PVD cases; diabetes in 11.5% of CVD and in 18% of PVD cases; hyperlipidaemia in 31 % of CVD and 24% of PVD cases; migraine in 11% of CVD and 1% of PVD cases.
Hemodynamic Response to Oral Prenalterol in Dilated Decompensated Cardiomyopathy as a Result of Cardiac and Vascular Effects
Authors: Guazzi Maurizio D. , Agostoni Pier Giuseppe , Doria Elisabetta , Loaldi Alessandro , Pepi Mauro , Polese Alvise 
Published: November 2007

The initial antifailure efficacy of beta-adrenergic agonists is generally lost during prolonged treatment. The reasons are not fully understood. In 11 patients with advanced cardiac decompensation due to dilated cardiomyopathy, prenalterol, a selective beta 1 adrenergic agonist, improved the left ventricular contractility after acute intravenous and during prolonged oral administration. However, after periods of treatment ranging from 2 to 18 weeks, blood pressure and systemic vascular resistance were raised in each patient. These changes resulted in an increase of the left ventricular afterload which was such as to overwhelm the effects of the enhanced contractility, and to extinguish the initial improvement of the cardiac function and of the clinical condition. Stimulation of the presynaptical beta-receptors facilitating norepinephrine release or of the renin secretion by this beta1 agonist, may be the causes of the systemic vasoconstriction and of the loss of effectiveness in the long run.
CL115,347, an Analogue of Prostaglandin E2
Authors: Cooke E.D. , Bowcock Sally A. , Watkins C.J. , Rustin M.H.A. , Kirby J.D.T. 
Published: November 2007

The beneficial effects of intra-arterial or intravenous infusion of the prostanoid products of anachridonic acid, PGE and prostacyclin (PGI2) are well documented. More recently an analogue of PGE2, (CL 115,347, American Cynamid Co.) has become available. This substance is absorbed transdermally from a patch placed on the skin. In a placebo-controlled trial the vasodilatory effect of single incremental dosage, 500 mcg, 1000 mcg and 1500 mcg, was measured in a temperature-/humidity controlled laboratory in normal subjects and in patients with primary and secondary Raynaud's phenomenon. The optimal dosage proved to be 1000 mcg; the effect may last for 84 hours; higher dosage may be associated with a "steal" phenomenon.
Chronic Venous Insufficiency — Clinical and Therapeutic Approach
Authors: Goitia Hugo F. , Dipietro Antonio , Gatta Felix 
Published: November 2007

Chronic venous insufficiency is defined as a state of venous hypertension that is shown by two big syndromes: the edematous and the indurating hypodermitis. The common characteristic of this pathology is the claudication of the valve function; the most frequent cases being in descending order, are the following: 1) Post-traumatic syndrome, 2) Essential insufficiency, 3) Artenovenous fistula, 4) Angioplasies. 1
Effects of Intravenous Glycerol on Cerebral Blood Flow and Tissue Metabolism in Acute Cerebral Ischemia in Spontaneously Hypertensive Rats
Authors: Fujishima Masatoshi , Ishitsuka Takao , Yoshida Fujio , Ibayashi Setsuro , Shiokawa Osamu , Sadoshima Seizo 
Published: November 2007

The effects of antiedematous agent with intravenous 10% glycerol on cere bral blood flow (CBF) and metabolism were studied in acute cerebral ischemia experimentally induced by bilateral carotid artery occlusion in spontaneously hypertensive rats (SHR). CBF was measured by the hydrogen clearance tech nique and brain tissue metabolites such as lactate, pyruvate and ATP in the ischemic brain frozen in situ were determined by the enzymatic method. In comparison with saline-infused SHR, the reduction of CBF in the thala mus following carotid occlusion was significantly small in the glycerol treated SHR. Supratentorial ATP concentration in the 3 hr-ischemic brain was reduced in both groups of rats, but its reduction was significantly smaller in the glycerol- infused group than the other. Lactate and lactate/pyruvate ratio tended to be less increased in the glycerol rats, indicating that ischemic metabolism was re strained by the treatment. The present results strongly suggest that intravenous glycerol is effective against acute cerebral ischemia from the view point of cerebral hemodynamic and metabolism.
Platelet Hyperaggregability, Blood Prostacyclin and Dipyridamole
Authors: Solvay H. , Kahn M. , Cloarec M. , Van De Merckt J. , Sneppe R. , Schram E. , Fenollar J.V. 
Published: November 2007

This study demonstrates the presence of PGI2 in blood and its influence on platelet retention tests, possibly by the intermediate of a releasing system in the columns, which is followed by a proximate recuperation on the erythrocyte sites after the passage. The presence of prostacyclin on the erythrocyte sites seems to depend upon the red cell deformability in relation to the good condition of their erythrycote ATP reserve. The load of the erythrocyte sites increases with the daily dose of dipyrida mole. The maximum load of the sites appears to be reached with a daily dose of dipyridamole 450mg. Approximately 10% of the atherosclerosis patients who have been treated by dipyridamole keep their platelet hyperaggregability and their abnormally low ered prostacyclin level.