bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of Infarct Morphology and Patterns on Cognitive Outcomes After Endovascular Thrombectomy
Authors: Ospel Johanna Maria , Rinkel Leon , Ganesh Aravind , Demchuk Andrew , Joshi Manish , Poppe Alexandre , McTaggart Ryan , Nogueira Raul , Menon Bijoy , Tymianski Michael , Hill Michael Douglas , Goyal Mayank 
Published: March 2024

BACKGROUND:
To assess the association of qualitative and quantitative infarct characteristics and 3 cognitive outcome tests, namely the Montreal Cognitive Assessment (MOCA) for mild cognitive impairment, the Boston Naming Test for visual confrontation naming, and the Sunnybrook Neglect Assessment Procedure for neglect, in large vessel occlusion stroke.

METHODS:
Secondary observational cohort study using data from the randomized-controlled ESCAPE-NA1 trial (Safety and Efficacy of Nerinetide in Subjects Undergoing Endovascular Thrombectomy for Stroke), in which patients with large vessel occlusion undergoing endovascular treatment were randomized to receive either intravenous Nerinetide or placebo. MOCA, Sunnybrook Neglect Assessment Procedure, and 15-item Boston Naming Test were obtained at 90 days. Total infarct volume, gray matter, and white matter infarct volumes were manually measured on 24-hour follow-up imaging. Infarcts were also visually classified as either involving the gray matter only or both the gray and white matter and scattered versus territorial. Associations of infarct variables and cognitive outcomes were analyzed using multivariable ordinal or binary logistic regression models.

RESULTS:
Of 1105 patients enrolled in ESCAPE-NA1, 1026 patients with visible infarcts on 24-hour follow-up imaging were included. MOCA and Sunnybrook Neglect Assessment Procedure were available for 706 (68.8%) patients and the 15-item Boston Naming Test was available for 682 (66.5%) patients. Total infarct volume was associated with worse MOCA scores (adjusted common odds ratio per 10 mL increase, 1.05 [95% CI, 1.04–1.06]). After adjusting for baseline variables and total infarct volume, mixed gray and white matter involvement (versus gray matter-only adjusted common odds ratio, 1.92 [95% CI, 1.37–2.69]), white matter infarct volume (adjusted common odds ratio per 10 mL increase 1.36 [95% CI, 1.18–1.58]) and territorial (versus scattered) infarct pattern (adjusted common odds ratio, 1.65 [95% CI, 1.15–2.38]) were associated with worse MOCA scores. Results for Sunnybrook Neglect Assessment Procedure and 15-item Boston Naming Test were similar, except for the territorial infarct pattern, which did not reach statistical significance in multivariable analysis.

CONCLUSIONS:
Besides total infarct volume, infarcts that involve the white matter and that show a territorial distribution were associated with worse cognitive outcomes, even after adjusting for total infarct volume.
Zuidervaart and Dooyeweerd: A Critical Retrieval?
Authors: Geertsema Henk G. 
Published: March 2024

Abstract
In this review essay, I discuss how Lambert Zuidervaart relates to the philosophy of Herman Dooyeweerd in two of his books. He himself calls his work in this regard a critical retrieval. To answer the question as to how far this characterization is justified, we will look at Zuidervaart’s discussion of the religious antithesis and the transcendental critique, his idea of macrostructures and societal evil, and his view of truth and knowledge.
Empowering smart cities with digital twins of buildings: Applications and implementation considerations of data-driven energy modelling in building management
Authors: Elnour Mariam , Ahmad Ahmad M. , Abdelkarim Shimaa , Fadli Fodil , Naji Khalid 
Published: March 2024

Smart buildings and cities are rapidly emerging as solutions to address the challenges of efficiency, urbanisation, and sustainability in the sector. The study proposes deploying data-driven digital twins for smart buildings by utilising the available building’s technology and IT infrastructure to complement and augment existing functions. The digital twin will consist of a core data-driven energy model and a 2D visual representation of the building’s systems, with the potential for future evolution into a 3D model. This study aims to present a preliminary investigation into the idea of data-driven digital twins in building management towards enhancing the operations of smart buildings and empowering the concept of smart cities. It is demonstrated on a building on the campus of Qatar University. With an emphasis on the air conditioning systems of the building, considering their substantial contribution to overall energy consumption, the study maintains an open approach to also encompass other energy systems within the buildings, and presents a comparative evaluation between simulation-based and data-driven modelling on the case study, as well as an exploration of various machine learning algorithms that can be used. Furthermore, exploring essential smart applications of the building’s data-driven digital twin. Practical Application The study provides a comprehensive exploration of the practical aspects of deploying data-driven digital twins for smart buildings, addressing challenges related to data collection, model development, integration with building infrastructure, and potential limitations. The paper aims to advance the field of facility management and promote smart and sustainable practices in building operations. By contributing to the existing knowledge in facility services and management, our study offers practical guidance towards optimising building performance, reducing energy consumption, and fostering sustainable urban development.
Transforming the Performance Management System at Sapient
Authors: Gupta Pooja , Sethi Madhvi 
Published: March 2024

In 2013, Alan Herrick, the CEO of Sapient, raised concerns with his HR leadership regarding the effectiveness of the existing performance management system (PMS). He tasked Kameshwari Rao, Vice President of People Strategy at Sapient India, with evaluating the current performance appraisal system, which relied on bell curving and forced ranking. Leading a core team, Rao explored alternative systems to replace the current one, eliminating the use of the bell curve. The team’s findings led to the proposal of a new approach named ‘enabling your potential’ (EYP), focusing on regular conversations throughout the year rather than a singular year-end effort for gathering and disseminating performance information. The EYP approach emphasized coaching and feedback. The case outlines the dilemma faced by Rao when confronted with feedback from various organizational stakeholders regarding the proposed EYP PMS. Rao must decide whether to persist with the bell curve system or adopt the proposed EYP approach.
Innovation in hospital pharmacy: Modeling the installation of automated dispensing systems based on an oncology hospital experience transfer
Authors: El Baraka Soumaya , Cherif Chefchaouni Ali , Bourdaime Aya , Lahlou Oumaima , El Alaoui Yassir , Rahali Younes 
Published: March 2024

Objective This study explores automated dispensing systems (ADS) implementation in hospitals, focusing on experience transfer between the National Institute of Oncology of Rabat (NIO) and the specialties hospital of Rabat (SHR) to develop a transferable ADS installation and management model. Method A retrospective implementation and experience data analysis of 3 years ADS implementation at NIO and a prospective planification for SHR new implementation on 6 months were employed. Data collection included pharmacist team reports, personnel interviews, direct observations, and information system data exports. The study focused on identifying challenges a plan-do-check-act (PDCA) cycle. Results The analysis revealed overestimation in ADS needs at NIO about 42%, leading to: Resource exhaustion; Challenges in timeline installation staff training and management, Disruptions in data integration and Incident Reports. These issues underscored the importance of a phased, well-planned implementation process. Discussion The study highlighted the crucial role of many comprehensive strategies. In accordance with the results of several studies, this work demonstrates the benefits of ADS in reducing medication errors and enhancing resource management, while also pointing out the necessity for accurate system sizing, effective integration with hospital information systems, and comprehensive staff training. Conclusion The experience transfer between NIO and SHR provides a valuable model for ADS implementation in hospital pharmacies, proposing optimizations on: Implementation process; Timelines and mapping; Risk management and incident reports; Staff training, sensibilization and change control.
A retrospective audit of general practitioner’s referrals to Guys and St Thomas’ specialist menopause clinic between 2021 and 2022
Authors: Tedajo Tsambou Jocelyne , Bruce Deborah , Holloway Debra , Rymer Janice 
Published: March 2024

Purpose: We performed a retrospective audit of General Practitioners’ (GPs) referrals to the specialist Menopause Clinic at Guys and St Thomas’s (GSTT) between 2021 and 2022. We aim to establish the indication for the referrals and whether they were compliant with the National Institute for Health and Care Excellence Guidance NICE. Background: GSTT is a teaching hospital in central London that educates gynaecologists in training as well as (GP) for specialist certification in Menopause. The menopause clinic receives approximately 580 GP referrals per month from South East London practices. The current waiting time for an initial appointment is up to 1 year. This delay reflects an increase in demand for menopause care and a deficit in service provision in many areas of the UK. NICE has recommended that GPs refer complicated cases to menopause specialists, with 11 specific criteria. Study Sample and Data Collection: We randomly selected 50 patients referred to the GSTT clinic by a GP between 2021 and 2022. Patient data were collected, including patient demographics, date of referral, indication for referral, date of consultation, waiting time, past medical history, investigations, and treatment instigated during the appointment. Results: The majority of referrals to the GSTT menopause Specialist clinic met the NICE guidelines (76%). One-sixth of the referrals could have been prevented or managed through alternative routes. Finally, although this is a small study, some patient unmet needs (PUNS) and GPs’ educational needs have been identified.
The Intersections Between Sexual Orientation, Latine Ethnicity, Social Determinants of Health, and Lifetime Suicide Attempts in a Sample Being Assessed for Entry to Co-Occurring Mental Health and Substance Use Disorder Treatment
Authors: Modeste-James Akeem , Fitzgerald Therese , Stewart Emily , De Jesus Diliana , Canuto Melisa , Guzman Micaurys , Mateo Jessica , D’lppolito Melinda , Lundgren Lena 
Published: March 2024

Purpose: Few studies have examined the relationship between the intersections of lesbian, gay, and bisexual (LGB) sexual orientation, Latine ethnicity, and lifetime suicide attempts in Latine individuals with substance use disorder. This study examines this intersection and controls for social determinants of health, mental health disorder symptoms, and substance use disorder symptoms in a sample of Latine adults entering treatment for co-occurring disorders. Method: Bivariate statistics and multivariate logistic regression were used to analyze assessment data (n = 360) from a bilingual/bicultural integrated behavioral health system serving Latine communities in Massachusetts to examine the relationship between sexual orientation, Latine ethnicity, and history of lifetime suicide attempts. We controlled for social determinants of health, mental health disorders, and substance use disorder (SUD) factors significantly associated with lifetime suicide attempts at the bivariate level. Results: Over 27% of the sample and 35% of Puerto Ricans (PR) reported lifetime suicide attempts. The logistic regression identified that PR clients were 78% more likely to have attempted suicide in a lifetime compared to non-PR clients. Clients identifying as LGB were 3.2 times more likely to report having attempted suicide in their lifetime compared to heterosexual clients. Unemployed clients were 2.4 times more likely to report having attempted suicide in their lifetime compared to employed clients. Conclusion: Findings identify high rates of lifetime suicide attempts among LGBs and PRs entering SUD treatment. Targeted outreach and treatment efforts designed to address intersectionality for this underserved population are needed.
Transcriptomic and physiological analyses of Trichoderma citrinoviride HT-1 assisted phytoremediation of Cd contaminated water by Phragmites australis
Authors: Chen DaWei , Wang YiHan , Li Ni , Huang YaLi , Mao YiFan , Liu XiaoJun , Du YaRong , Sun Kun 
Published: March 2024

AbstractPlant growth promoting microbe assisted phytoremediation is considered a more effective approach to rehabilitation than the single use of plants, but underlying mechanism is still unclear. In this study, we combined transcriptomic and physiological methods to explore the mechanism of plant growth promoting microbe Trichoderma citrinoviride HT-1 assisted phytoremediation of Cd contaminated water by Phragmites australis. The results show that the strain HT-1 significantly promoted P. australis growth, increased the photosynthetic rate, enhanced antioxidant enzyme activities. The chlorophyll content and the activity of superoxide dismutase (SOD), peroxidase (POD), catalase (CAT) and ascorbate peroxidase (APX) were increased by 83.78%, 23.17%, 47.60%, 97.14% and 12.23% on average, and decreased the content of malondialdehyde (MDA) by 31.10%. At the same time, strain HT-1 improved the absorption and transport of Cd in P. australis, and the removal rate of Cd was increased by 7.56% on average. Transcriptome analysis showed that strain HT-1 induced significant up-regulated the expression of genes related to oxidative phosphorylation and ribosome pathways, and these upregulated genes promoted P. australis remediation efficiency and resistance to Cd stress. Our results provide a mechanistic understanding of plant growth promoting microbe assisted phytoremediation under Cd stress.
Neuroscience of taste: unlocking the human taste code
Authors: Hellekant Göran 
Published: March 2024

AbstractSince antiquity human taste has been divided into 4–5 taste qualities. We realized in the early 1970s that taste qualities vary between species and that the sense of taste in species closer to humans such as primates should show a higher fidelity to human taste qualities than non-primates (Brouwer et al. in J Physiol 337:240, 1983). Here we present summary results of behavioral and single taste fiber recordings from the distant South American marmoset, through the Old World rhesus monkey to chimpanzee, the phylogenetically closest species to humans. Our data show that in these species taste is transmitted in labelled-lines to the CNS, so that when receptors on taste bud cells are stimulated, the cell sends action potentials through single taste nerve fibers to the CNS where they create taste, whose quality depends on the cortical area stimulated. In human, the taste qualites include, but are perhaps not limited to sweet, sour, salty, bitter and umami. Stimulation of cortical taste areas combined with inputs from internal organs, olfaction, vision, memory etc. leads to a choice to accept or reject intake of a compound. The labelled-line organization of taste is another example of Müller’s law of specific nerve energy, joining other somatic senses such as vision (Sperry in J Neurophysiol 8:15–28, 1945), olfaction (Ngai et al. in Cell 72:657–666, 1993), touch, temperature and pain to mention a few.
Transcriptome sequencing and expression analysis in peanut reveal the potential mechanism response to Ralstonia solanacearum infection
Authors: Wang Xiao , Qi Feiyan , Sun Ziqi , Liu Hongfei , Wu Yue , Wu Xiaohui , Xu Jing , Liu Hua , Qin Li , Wang Zhenyu , Sang Suling , Dong Wenzhao , Huang Bingyan , Zheng Zheng , Zhang Xinyou 
Published: March 2024

Abstract
Background
Bacterial wilt caused by Ralstonia solanacearum severely affects peanut (Arachis hypogaea L.) yields. The breeding of resistant cultivars is an efficient means of controlling plant diseases. Therefore, identification of resistance genes effective against bacterial wilt is a matter of urgency. The lack of a reference genome for a resistant genotype severely hinders the process of identification of resistance genes in peanut. In addition, limited information is available on disease resistance-related pathways in peanut.

Results
Full-length transcriptome data were used to generate wilt-resistant and -susceptible transcript pools. In total, 253,869 transcripts were retained to form a reference transcriptome for RNA-sequencing data analysis. Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis of differentially expressed genes revealed the plant-pathogen interaction pathway to be the main resistance-related pathway for peanut to prevent bacterial invasion and calcium plays an important role in this pathway. Glutathione metabolism was enriched in wilt-susceptible genotypes, which would promote glutathione synthesis in the early stages of pathogen invasion. Based on our previous quantitative trait locus (QTL) mapping results, the genes arahy.V6I7WA and arahy.MXY2PU, which encode nucleotide-binding site-leucine-rich repeat receptor proteins, were indicated to be associated with resistance to bacterial wilt.

Conclusions
This study identified several pathways associated with resistance to bacterial wilt and identified candidate genes for bacterial wilt resistance in a major QTL region. These findings lay a foundation for investigation of the mechanism of resistance to bacterial wilt in peanut.
Mycobacterium tuberculosis sepsis with multiple intermuscular abscesses and respiratory failure as the main manifestations: a case report
Authors: Tang Yingzi , Zhu Ying , You Zhonglan 
Published: March 2024

Abstract
Background
Tuberculous sepsis is uncommon in individuals without human immunodeficiency virus (HIV) infection, and some patients may not exhibit clinical signs and symptoms of suspected sepsis upon admission, leading to delayed diagnosis and treatment.

Case presentation
This report present the case of a 60-year-old female patient who presented with erythema, edema, and pain in her right upper limb accompanied by fever and chills. Further evaluation revealed multiple intermuscular abscesses caused by suspected gram-positive bacteria. Despite receiving anti-infection treatment, the patient rapidly progressed to septic shock and respiratory failure. Metagenomic next-generation sequencing (mNGS) analysis of blood samples detected Mycobacterium tuberculosis complex groups (11 reads). Additionally, mNGS analysis of fluid obtained from puncture of the abscess in the right upper extremity also suggested Mycobacterium tuberculosis complex groups (221 981 reads). Consequently, the patient was diagnosed with tuberculous sepsis resulting from hematogenous dissemination of Mycobacterium tuberculosis. Following the administration of anti-tuberculosis treatment, a gradual recovery was observed during the subsequent follow-up period.

Conclusion
It is noteworthy that atypical hematogenous disseminated tuberculosis can be prone to misdiagnosis or oversight, potentially leading to septic shock. This case illustrates the importance of early diagnosis and treatment of tuberculosis sepsis. Advanced diagnostic techniques such as mNGS can aid clinicians in the early identification of pathogens for definitive diagnosis.
Malignancy diagnosis of liver lesion in contrast enhanced ultrasound using an end-to-end method based on deep learning
Authors: Zhou Hongyu , Ding Jianmin , Zhou Yan , Wang Yandong , Zhao Lei , Shih Cho-Chiang , Xu Jingping , Wang Jianan , Tong Ling , Chen Zhouye , Lin Qizhong , Jing Xiang 
Published: March 2024

Abstract
Background
Contrast-enhanced ultrasound (CEUS) is considered as an efficient tool for focal liver lesion characterization, given it allows real-time scanning and provides dynamic tissue perfusion information. An accurate diagnosis of liver lesions with CEUS requires a precise interpretation of CEUS images. However,it is a highly experience dependent task which requires amount of training and practice. To help improve the constrains, this study aims to develop an end-to-end method based on deep learning to make malignancy diagnosis of liver lesions using CEUS.

Methods
A total of 420 focal liver lesions with 136 benign cases and 284 malignant cases were included. A deep learning model based on a two-dimensional convolution neural network, a long short-term memory (LSTM), and a linear classifier (with sigmoid) was developed to analyze the CEUS loops from different contrast imaging phases. For comparison, a 3D-CNN based method and a machine-learning (ML)-based time-intensity curve (TIC) method were also implemented for performance evaluation.

Results
Results of the 4-fold validation demonstrate that the mean AUC is 0.91, 0.88, and 0.78 for the proposed method, the 3D-CNN based method, and the ML-based TIC method, respectively.

Conclusions
The proposed CNN-LSTM method is promising in making malignancy diagnosis of liver lesions in CEUS without any additional manual features selection.
Comparing the efficacy of a multi-dimensional breast cancer rehabilitation programme versus a home-based exercise programme during adjuvant cancer treatment
Authors: Chandran Gobinathan , Tang Ning , Ngo Ednajoy Lay Poh , Huang Serene , Tong Shuk In , Ong Jie Xin , Chew Effie 
Published: March 2024

Abstract
Background
Breast cancer is the most common female malignancy worldwide and a major cause of morbidity and mortality. Exercise during adjuvant treatment improves function and relieves symptoms in breast cancer survivors. However, it is unclear if an unsupervised exercise programme may be as effective as a supervised multimodal group. We investigated the feasibility and efficacy of a centre-based multidimensional rehabilitation (MDR) programme for breast cancer survivors undergoing adjuvant treatment and compared it to an unsupervised home-based exercise (HE) programme.

Methods
Participants were self-allocated to either MDR or HE group. MDR participants underwent 24 supervised exercise classes and 10 education classes over 12 weeks. HE participants were instructed on a home exercise regime. Outcome measures, including the 6-min walk test (6MWT) and Frenchay Activities Index (FAI), FACT-Cognitive Function scale, and European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30, were conducted at baseline (W0), post-intervention (W12) and 6-months post-intervention (M6). Variance between time points and the 2 groups were analysed using a linear mixed model (unstructured covariance matrix) and adjusted with Bonferroni.

Result
Twenty-five participants attended at least half of the MDR interventions, while 21 completed the HE interventions. The former showed significant improvement in 6MWT, from 406.88 m (W0) to 443.34 m (W12) to 452.81 m (M6), while the improvement in the HE group was not significant (407.67 m (W0) to 433.14 m (W12) to 430.96 m (M6)). Both groups showed a significant improvement in FAI, with earlier significant improvement noted at W12 in the MDR group (22.71 (W0) to 27.65 (W12) to 28.81 (M6)) compared to the HE group (23.16 (W0) to 26.47 (W12) to 29.85 (M6)). Dropout rate was 16% in the MDR group and 34% in HE group. Overall satisfaction with the MDR programme was high.

Conclusion
Both MDR and HE programmes were feasible. MDR was superior in improving endurance and earlier return to instrumental activities for those who completed at least half of the sessions. Future studies could explore use of technology to improve adherence to exercise.

Trial registration
The study was registered with ClinicalTrial.gov on 01/04/2022 with the registration number NCT05306808.