bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metabolic imbalance driving immune cell phenotype switching in autoimmune disorders: Tipping the balance of T‐ and B‐cell interactions
Authors: Barberis Matteo , Rojas López Alejandra 
Published: March 2024

AbstractThe interplay between the immune system and the metabolic state of a cell is intricate. In all phases of an immune response, the corresponding metabolic changes shall occur to support its modulation, in addition to the signalling through the cytokine environment and immune receptor stimulation. While autoimmune disorders may develop because of a metabolic imbalance that modulates switching between T‐cell phenotypes, the effects that the interaction between T and B cells have on one another's cellular metabolism are yet to be understood in disease context. Here, we propose a perspective which highlights the potential of targeting metabolism to modulate T‐ and B‐cell subtypes populations as well as T–B and B–T cell interactions to successfully treat autoimmune disorders. Specifically, we envision how metabolic changes can tip the balance of immune cells interactions, through definite mechanisms in both health and disease, to explain phenotype switches of B and T cells. Within this scenario, we highlight targeting metabolism that link inflammation, immunometabolism, epigenetics and ageing, is critical to understand inflammatory disorders. The combination of treatments targeting immune cells that cause (T/B) cell phenotype imbalances, and the metabolic pathways involved, may increase the effectiveness of treatment of autoimmune disorders, and/or ameliorate their symptoms to improve patients’ quality of life.
Green and Hawksbill Sea turtles of Eastern Atlantic: New insights into a globally important rookery in the Gulf of Guinea
Authors: Ferreira‐Airaud Betânia , Vieira Sara , Branco Maria , Pina Antunes , Soares Venceslau , Tiwari Manjula , Witt Matthew , Castilho Rita , Teodósio Alexandra , Hawkes Lucy A. 
Published: March 2024

AbstractSea turtles are critical components of marine ecosystems, and their conservation is important for Ocean Governance and Global Planet Health. However, there is limited knowledge of their ecology in the Gulf of Guinea. To fill this knowledge gap, this study presents the first integrative assessment of green and hawksbill turtles in the region, combining nesting surveys over 9 years and telemetry data, to offer insights into these population dynamics, and behaviours, including nesting preferences, morphological and reproductive parameters, diving patterns and inter‐nesting core‐use areas. Both green and hawksbill turtles are likely making a recovery on São Tomé, potentially driven by sustained conservation efforts. There are preliminary indications of recovery, but we interpret this cautiously. Coupled with satellite tracking, this study estimated that 482 to 736 green turtles and 135 to 217 hawksbills nest on the beaches of São Tomé. Their movements overlap significantly with a proposed Marine Protected Area (MPA), which suggests they may be well placed for conservation if managed appropriately. However, the presence of artisanal fisheries and emerging threats, such as sand mining and unregulated tourism, highlight the urgent need for robust management strategies that align global conservation objectives with local socioeconomic realities. This study significantly enhances our understanding of the ecology and conservation needs of the green and hawksbill turtles in the Gulf of Guinea. The insights gleaned here can contribute to the development of tailored conservation strategies that benefit these populations and the ecosystem services upon which they depend.
Assessment of environmental water strategies for improving fringing vegetation health by modelling vegetation condition in a connected floodplain lakes system
Authors: Wu Chunying , Webb J. Angus , Stewardson Michael J. 
Published: March 2024

AbstractAcross the globe, environmental water has been allocated with the purpose of preserving the health and vitality of floodplain vegetation. However, the influences of environmental water volume and environmental water delivery strategies have not been studied widely because of shortage of on‐ground monitoring data. Remotely sensed data can bridge this gap by providing long‐term and continuous information; Landsat imagery from 1988 to 2020 was used in this research. We used the normalized difference vegetation index (NDVI) as an indicator of physiological condition of lake‐fringing trees on the Hattah Lakes floodplain, south‐east Australia. We employed the random forest (RF) regression method to model the relationship between NDVI and various climate and hydrological factors, such as the volume of water delivered to the connected lakes system as environmental water allocations or natural floods. The RF models performed well overall, with a mean R2 value of 0.73. The analysis identified the monthly total of environmental water delivered 3 months prior to the Landsat image date as a more crucial factor than natural floods over the same period for driving vegetation condition. Environmental water from 3 months previously exerts a positive influence on NDVI until the volume reaches a specific threshold. We have observed significant improvements in floodplain vegetation through the current environmental water strategy, particularly since the construction of pumping infrastructure in 2013. We suggest that managers aim to inundate the lake fringing area every 3 years, specifically from August to September, by delivering environmental water up to the modelled threshold volume. Finally, the use of infrastructure has proven to be an effective and efficient method for irrigating floodplain lakes, leading to improvements in vegetation condition while conserving water resources.
Restoration of an Indigenous aquaculture system can increase reef fish density and fisheries harvest in Hawai‘i
Authors: Innes‐Gold Anne A. , Madin Elizabeth M. P. , Stokes Kaci , Ching Casey , Kawelo Hi‘ilei , Kotubetey Keli‘i , Reppun Frederick , Rii Yoshimi M. , Winter Kawika B. , McManus Lisa C. 
Published: March 2024

AbstractWhile aquaculture is increasingly considered a globally important source of protein, growing fish for human consumption is not new. Indigenous aquaculture systems, such as loko i‘a (fishponds), were successfully implemented in ancient Hawai‘i and represent a technological advancement designed to sustain a growing human population while maintaining—instead of supplanting—natural ecosystem function in the process of increasing food availability. Biocultural restoration efforts in Hawai‘i, aimed at revitalizing Indigenous stewardship, have included restoration of loko i‘a to sustainably increase the availability of local seafood. While it is clear from historical accounts that loko i‘a can augment fish within estuaries, their role as a nursery ground that supplements surrounding fish populations and fisheries harvest (i.e., providing spillover) remains unstudied in the current literature. This study aimed to test the extent to which loko i‘a restoration can supplement fish populations and fisheries harvest both inside the loko i‘a and in the surrounding waters. A food web model was constructed representing nutrients, phytoplankton, fish, and fisheries in three distinct habitats. The model, set in Kāne‘ohe Bay, O‘ahu, Hawai‘i, revealed that there were interactive effects of the area under loko i‘a management, bay fishing effort, and fish dispersal rates on fish density and fisheries harvest. We found that increasing the area under loko i‘a management not only increased loko i‘a fish density and fisheries harvest but also created the potential to supplement bay fish populations and fisheries harvest under certain scenarios. We also identified a trade‐off whereby at high fish dispersal rates, a larger area under loko i‘a management provided maximal benefits to the bay fish population and fisheries harvest, while at low fish dispersal rates, a smaller area under loko i‘a management was more beneficial to bay fish populations and harvest. As expected, loko i‘a also created a surplus of fish within the pond. Our results support the idea that restoration of Indigenous aquaculture systems can positively impact conservation efforts and food security by increasing local fish availability, through both direct production and supplementation of surrounding fish stocks.
Deconstructing the mangrove carbon cycle: Gains, transformation, and losses
Authors: Adame M. F. , Cormier N. , Taillardat P. , Iram N. , Rovai A. , Sloey T. M. , Yando E. S. , Blanco‐Libreros J. F. , Arnaud M. , Jennerjahn T. , Lovelock C. E. , Friess D. , Reithmaier G. M. S. , Buelow C. A. , Muhammad‐Nor S. M. , Twilley R. R. , Ribeiro R. A. 
Published: March 2024

AbstractMangroves are one of the most carbon‐dense forests on the Earth and have been highlighted as key ecosystems for climate change mitigation and adaptation. Hundreds of studies have investigated how mangroves fix, transform, store, and export carbon. Here, we review and synthesize the previously known and emerging carbon pathways in mangroves, including gains (woody biomass accumulation, deadwood accumulation, soil carbon sequestration, root and litterfall production), transformations (food web transfer through herbivory, decomposition), and losses (respiration as CO2 and CH4, litterfall export, particulate and dissolved carbon export). We then review the technologies available to measure carbon fluxes in mangroves, their potential, and their limitations. We also synthesize and compare mangrove net ecosystem productivity (NEP) with terrestrial forests. Finally, we update global estimates of carbon fluxes with the most current values of fluxes and global mangrove area. We found that the contributions of recently investigated fluxes, such as soil respiration as CH4, are minor (<1 Tg C year−1), while the contributions of deadwood accumulation, herbivory, and lateral export are significant (>35 Tg C year−1). Dissolved inorganic carbon exports are an order of magnitude higher than the other processes investigated and were highly variable, highlighting the need for further studies. Gross primary productivity (GPP) and ecosystem respiration (ER) per area of mangroves were within the same order of magnitude as terrestrial forests. However, ER/GPP was lower in mangroves, explaining their higher carbon sequestration. We estimate the global mean mangrove NEP of 109.1 Tg C year−1 (7.4 Mg C ha−1 year−1) or through a budget balance, accounting for lateral losses, a global mean of 66.6 Tg C year−1 (4.5 Mg C ha−1 year−1). Overall, mangroves are highly productive, and despite losses due to respiration and tidal exchange, they are significant carbon sinks.
Comparison of sediment and water column nutrient processing rates in agricultural streams of contrasting buffer land use
Authors: Larson James H. , Bailey Sean W. , Kreiling Rebecca M. , Bartsch Lynn A. , Frost Paul C. , Xenopoulos Marguerite A. , Pearce Nolan J. T. , Evans Mary Anne 
Published: March 2024

AbstractWatershed nutrient management often focuses on actions that reduce the movement of nitrogen (N) and phosphorus (P) from agricultural lands into streams. One area of management focus is the buffer of land adjacent to streams. Wetlands and forests in this buffer can intercept and retain N and P from the landscape. In addition to directly intercepting agricultural nutrients, natural habitats in the buffer can alter stream geomorphology and influence the in‐stream processing and transformation of N and P to less labile and mobile forms. Here, we assess the influence of buffer land cover on in‐stream processing of N and P. We measured nutrient dynamics in the water column and sediments of agricultural streams in the Fox River and Duck Creek watersheds (WI, USA) during the growing season. In these streams, water column processing was low, possibly due to a lack of primary producers in the water column. Water column P processing was weakly associated with wetland land cover in the buffer, but buffer land cover had no clear effect on inorganic N processing. On the other hand, sediments were almost always a source of inorganic P and a sink for inorganic N. Sediment P release was higher in streams with more agricultural land cover in the buffer. Sediments in streams with agricultural land cover in the buffer also removed more nitrate, even after accounting for the greater availability of nitrate in those streams. The buffer land cover conditions we quantified occupy a very small portion of the overall watershed (100 m wide, for 1 km upstream of the study site) but nevertheless appear to influence in‐stream cycling of N and P. For P management, reducing agricultural land cover in buffers is already a priority due to the ability of wetlands and forests to intercept nutrients, but this study suggests there may be some additional benefit due to changes in in‐stream P processing.
Intestinal tissue‐resident memory T cells maintain distinct identity from circulating memory T cells after in vitro restimulation
Authors: Beumer‐Chuwonpad Ammarina , Behr Felix M. , van Alphen Floris P.J. , Kragten Natasja A. M. , Hoogendijk Arie J. , van den Biggelaar Maartje , van Gisbergen Klaas P.J.M. 
Published: March 2024

AbstractResident memory T (TRM) cells have been recently established as an important subset of memory T cells that provide early and essential protection against reinfection in the absence of circulating memory T cells. Recent findings showing that TRM expand in vivo after repeated antigenic stimulation indicate that these memory T cells are not terminally differentiated. This suggests an opportunity for in vitro TRM expansion to apply in an immunotherapy setting. However, it has also been shown that TRM may not maintain their identity and form circulating memory T cells after in vivo restimulation. Therefore, we set out to determine how TRM respond to antigenic activation in culture. Using Listeria monocytogenes and LCMV infection models, we found that TRM from the intraepithelial compartment of the small intestine expand in vitro after antigenic stimulation and subsequent resting in homeostatic cytokines. A large fraction of the expanded TRM retained their phenotype, including the expression of key TRM markers CD69 and CD103 (ITGAE). The optimal culture of TRM required low O2 pressure to maintain the expression of these and other TRM‐associated molecules. Expanded TRM retained their effector capacity to produce cytokines after restimulation, but did not acquire a highly glycolytic profile indicative of effector T cells. The proteomic analysis confirmed TRM profile retention, including expression of TRM‐related transcription factors, tissue retention factors, adhesion molecules, and enzymes involved in fatty acid metabolism. Collectively, our data indicate that limiting oxygen conditions supports in vitro expansion of TRM cells that maintain their TRM phenotype, at least in part, suggesting an opportunity for therapeutic strategies that require in vitro expansion of TRM.
Synthetic Studies and Structural Aspects of Dinuclear Sulfur Titanium Compounds
Authors: Álvarez‐Ruiz Elena , González‐Pérez Juan Ignacio , Hernán‐Gómez Alberto , Martín Avelino , Mena Miguel , Santamaría Cristina 
Published: March 2024

AbstractA series of dinuclear sulfur‐bridged titanium derivatives [Ti(η5‐C5Me5)R(μ‐S)]2 (R=NMe2 (1), Ph (2), CH2Ph (3), CH2SiMe3 (4)) has been synthesized from the reaction of [Ti(η5‐C5Me5)Cl(μ‐S)]2 with the corresponding lithium salt or Grignard reagent. Formulation of 1–4 as symmetric dimers has been confirmed by crystallographic studies. The analogous reaction with Mg(C3H5)Cl afforded the paramagnetic mixed‐valence Ti(III)/Ti(IV) compound [{Ti(η5‐C5Me5)(μ‐S)}2(μ‐C3H5)] (5). Contrasting with complexes 1–4, compound 5 exhibits a bridging μ‐CH2CHCH2 fragment between the titanium atoms, which prevents the formation of a planar Ti2S2 core in the solid‐state structure. Complex 1 reacts with SiH3Ph to give [{Ti(η5‐C5Me5)(μ‐S)}2(μ‐NMe2)] (6), a paramagnetic mixed‐valence Ti(III)/Ti(IV) compound, structurally and electronically similar to 5. Under mild conditions, treatment of compounds 3 and 4 with H2 (1 atm) generates quantitatively the Ti(III) tetrametallic sulfide cluster [Ti(η5‐C5Me5)(μ3‐S)]4, along with the corresponding alkane.
Erosion processes and sediment source tracing on heterogeneous slopes in the red soil region of southern China
Authors: Wu Tieniu , Lei Longyu , Luo Yuanyong , Zhang Hailin , Jie Yi , Liu Haijun 
Published: March 2024

AbstractUnderstanding erosion, sediment sources and the spatial distribution along heterogeneous slopes is essential for soil and water conservation. In this study, soils derived from nodular limestone, mud‐like limestone and limestone breccia (abbreviated as SMTL, SMDL and SLBC, respectively) were utilized to establish artificial homogeneous and heterogeneous slopes. The homogeneous slopes MTL, MDL and LBC represent SMTL‐, SMDL‐ and SLBC‐filled‐ slopes, respectively. The heterogeneous slopes were abbreviated as MTL/MDL, MDL/LBC and LBC/MTL. Rare earth elements (REEs; lanthanide, cerium and ytterbium) were used to tag soils on the upper and lower slope sections to track sediment transport and deposition. The results showed that for homogeneous slopes, the LBC slope was the most severely eroded, followed by the MDL and MTL slopes. For heterogeneous slopes, the order of erosion was LBC/MTL > MTL/MDL > MDL/LBC. Upslope sections contributed a sizable portion of the total sediment yield, ranging from 51% to 79%. Over time, the difference in the sediment contribution between the upslope and downslope regions decreased and reached equilibrium. Runoff rates on heterogeneous slopes demonstrated an inverse function (R2 > 0.75) in contrast to a logarithmic distribution (R2 > 0.87) on homogeneous slopes. Heterogeneous slopes displayed minimal intersegment variation and the absence of a consistent ordering of the magnitude of hydraulic parameters. Conversely, the hydraulic parameters of homogeneous slopes were consistently ordered across the slope sections. For sediment transport, all slopes exhibited suspension‐dominated flow with percentages greater than 89%. However, the particle size distribution of the sediment of heterogeneous slopes exhibited greater diversity and complexity because of the coexistence of distinct soils. These findings underscore the importance of customized strategies for soil and water conservation in environments characterized by diverse soil parent materials.
On robust boundary treatments for wall‐modeled LES with high‐order discontinuous finite element methods
Authors: Fukushima Yuma , Haga Takanori 
Published: March 2024

SummaryTo robustly and accurately simulate wall‐bounded turbulent flows at high Reynolds numbers, we propose suitable boundary treatments for wall‐modeled large‐eddy simulation (WMLES) coupled with a high‐order flux reconstruction (FR) method. First, we show the need to impose an auxiliary boundary condition on auxiliary variables (solution gradients) that are commonly introduced in high‐order discontinuous finite element methods (DFEMs). Auxiliary boundary conditions are introduced in WMLES, where the grid resolution is too coarse to resolve the inner layer of a turbulent boundary layer. Another boundary treatment to further enhance stability with under‐resolved grids, is the use of a modal filter only in the wall‐normal direction of wall‐adjacent cells to remove the oscillations. A grid convergence study of turbulent channel flow with a high Reynolds number () shows that the present WMLES framework accurately predicts velocity profiles, Reynolds shear stress, and skin friction coefficients at the grid resolutions recommended in the literature. It was confirmed that a small amount of filtering is sufficient to stabilize computation, with negligible influence on prediction accuracy. In addition, non‐equilibrium periodic hill flow with a curved wall, including flow separation, reattachment, and acceleration at a high Reynolds number (), is reported. Considering stability and the prediction accuracy, we recommend a loose auxiliary wall boundary conditions with a less steep velocity gradient for WMLES using high‐order DFEMs.
Fungal Carbon: A Cost‐Effective Tunable Network Template for Creating Supercapacitors
Authors: Jones Mitchell P. , Jiang Qixiang , Mautner Andreas , Naghilou Aida , Prado‐Roller Alexander , Wolff Marion , Koch Thomas , Archodoulaki Vasiliki‐Maria , Bismarck Alexander 
Published: March 2024

AbstractCarbons form critical components in biogas purification and energy storage systems and are used to modify polymer matrices. The environmental impact of producing carbons has driven research interest in biomass‐derived carbons, although these have yield, processing, and resource competition limitations. Naturally formed fungal filaments are investigated, which are abundantly available as food‐ and biotechnology‐industry by‐products and wastes as cost‐effective and sustainable templates for carbon networks. Pyrolyzed Agaricus bisporus and Pleurotus eryngii filament networks are mesoporous and microscale with a size regime close to carbon fibers. Their BET surface areas of ≈282 m2 g−1 and ≈60 m2 g−1, respectively, greatly exceed values associated with carbon fibers and non‐activated pyrolyzed bacterial cellulose and approximately on par with values for carbon black and CNTs in addition to pyrolyzed pinewood, rice husk, corn stover or olive mill waste. They also exhibit greater specific capacitance than both non‐activated and activated pyrolyzed bacterial cellulose in addition to YP‐50F (coconut shell based) commercial carbons. The high surface area and specific capacitance of fungal carbon coupled with the potential to tune these properties through species‐ and growth‐environment‐associated differences in network and filament morphology and inclusion of inorganic material through biomineralization makes them potentially useful in creating supercapacitors.
Negotiating the salientization of identity: Hindu? Indian? American?
Authors: Harshe Gaurav 
Published: March 2024

AbstractThis chapter starts by briefly decluttering how religion is defined through western theistic attributes, then explores students’ Hindu experiences while centering a counter socio‐religio‐cultural narrative of lived religion. I look into systemic institutional misalignments stemming from white Christian supremacy and lastly, aspects of student leadership on campuses. The chapter closes with critical reflections on scholar‐practitioner essays that address campus dynamics and my recommendations therefrom.Practical Takeaways
Supporting Hindu students requires a deeper understanding of Hindu traditions’ sociological, historical, and geographical roots as well as its contemporary manifestations in the US American diaspora and its complex relations to transnational social constructs.
Decentering white Christian manifestations in higher education settings for Hindu students can look like not requiring proof of “authenticity” for observances, alleviating programming and facilities hurdles, providing resources for physical spaces or offering reliable rides to places of worship, accommodating lacto‐vegetarian dietary needs, hiring dedicated staff that equitably enhance the internal diversity, and expanding interfaith engagements beyond Abrahamic faiths to include variably‐denominated Hindus.
Developing inter‐functional‐area policies to redress multiple layers of marginalized religious, spiritual, and secular identities in their relations to other identities including race, caste, ethnicity, tribe, gender, (dis)ability, sexuality, and class. This includes critically interrogating internalized forms of oppression.