bluuebunny/crossref_metadata_2025_split huggingface dataset:
Colistin-daptomycin, colistin-linezolid, colistin-vancomycin combination effects on colistin in multi-resistant acinetobacter baumannii strains
Authors: Irvem Arzu 
Published: February 2025

Objective: The most important problem in the treatment of nosocomial Acinetobacter baumannii (A. baumannii) infections which is increasingly seen in recent years is that almost all strains are resistant to many antibiotics, including carbapenems, and that the extinction of antibiotic options to be used in treatment. This leads the clinicians to new treatment options and suggests the use of combined antibiotics to achieve success in both the treatment of multi-drug-resistant A. baumannii (MDRAB) infections as well as to prevent resistance development. We investigated the in vitro activity of colistin in combination with vancomycin, linezolid or daptomycin against MDRAB to determine whether these combinations would be considered for clinical use. .
Methods: The fractional inhibitory concentration (FIC) index was used to determine the antibiotic combination effects and to evaluate the effect of antibiotic combinations on the bacteria.
Results: MIC values of colistin/vancomycin, colistin/linezolid, and colistin/daptomycin in 10 strains (33.3%) gave similar results. Twenty strains gave different MIC results according to antibiotics. The colistin/daptomycin antagonistic ratio was high when the colistin/vancomycin synergy ratio was high compared to the others.
Conclusion: Antibiotic combinations can be used as an alternative treatment approach in multi-drug resistant A. baumannii infections.
Coincidental Lesions that have been seen in Patients with Lumbar Discopathy at Spinal MR Examination
Authors: Ahmet Eroglu  , Ilhan Yilmaz  
Published: February 2025

Introduction: The present Study has been made in order to investigate and examine the prevalence and type of the coincidental findings seen in patients with lumbar discopathy subjected to Lumbar Spinal Magnetic Resonance Imaging (MRI).
Tools and Method: 613 patients who were thought to have been Lumbar discopathy and who were subjected to Lumbar MRI have been examined. Lumbar MRIs were reported by musculoskeletal radiologists. Vertebra hemangiomas, tarlov cysts, Renal cysts, schmorl nodules, liver cysts were included in this study.
Findings: Total 613 patients (male-female rate, 354: 259; age range, 16-79 years of age) were assessed. Vertebra Hemangiomas at 5.7% of the patients (n=35) vertebra hemangioma, at 3.5% of patients (n=22) tarlov cyst, at 2.2% (n=14) kidney cyst, at 1.4% (n=9) schmorl nodule, at 0.3% (n=2) of the patients liver cyst were found.
Conclusion: Detected coincidental findings have seen quite common at the examination of MRI of the patients with lumbar discopathy. Although the most of the coincidental findings which were detected at MRI of Lumbar Spine have been benign, the awareness of their prevalence is helpful in diagnosing the lesions which are not related with the symptoms.
Analysis of The Patients with Lichenoid Drug Reactions: A Retrospective Study.
Authors: Akbas Ayse , Kilinc Fadime 
Published: February 2025

Objective: Lichenoid drug reactions (LDR) are a rarely known type of drug reaction that resembles lichen planus. The exact etiology of LDR is not known but it is thought to be caused by the triggering of all kinds of chemical substances. In this study; we aimed to investigate the clinical and demographic characteristics of the patients who were diagnosed with LDR.
Material and Method: The files of 56 LDR patients who were followed in our outpatient clinic among 2011 - 2016 have been reviewed retrospectively. The demographic characteristics, the drugs considered to cause reaction, the presence of multiple drug usage, the duration between drug intake and appearance of the initial skin eruption, clinical findings, lesion locations, laboratory findings and associated diseases have been recorded.
Results: Out of the 56 LDR patients, who were clinically and histopathologically diagnosed and followed, 36 were female and 20 were male. The average age was 52.8 (19-86 years of age). The duration of the symptoms was between 1-3 months in 58.9% of the patients, between 3-12 months in % 17.8, between 1 to 30 days in % 14.2 (n=8) and more than 1 year in 8.9% of the patients.48.2% (n = 27) of the lesions were on the extremities, 37.5 % were generalized, 7.1% were invers type. The most frequently accused drug groups were nonsteroidal anti-inflammatory drugs (NSAID) and antihypertensive.
Conclusions: It has been found that the use of NSAID, and cardiovascular drugs on their own and / or in combination with other medications often led to lichenoid drug reactions.
Gastrointestinal stromal tumor mimicking such as incarcerated inguinal hernia
Authors: Ferhatoglu Murat Ferhat , Kartal Abdulcabbar , Kivilcim Taner 
Published: February 2025

Objective: Gastrointestinal stromal tumors, are most common sarcoma of the gastrointestinal tract, originate from Cajal cells which are responsible for the motility of the gastrointestinal tract. This sarcoma is most commonly observed in the stomach and small intestines can rarely be located in the omentum, mesentery or retroperitoneum.
Case: Herein, we aimed to present a case of gastrointestinal stromal tumor presented as incarcerated inguinal hernia
Is ultrasound-guided transversus abdominis plane block in providing analgesia in pediatric cases safe and efficient?: A retrospective study
Authors: Binici Orhan , Kocaman Osman Hakan , Buyukfirat Evren , Karahan Mahmut Alp , Altay Nuray 
Published: February 2025

Objective: The use of high or insufficient doses of analgesics in pediatric cases unfavorably affects the patient’s health in the postoperative period. Ultrasound-guided transversus abdominis plane (TAP) block is used in the management of postoperative pain in pediatric cases. The present study aims to evaluate the efficacy of ultrasound-guided TAP block in pediatric patients using a mixture of lidocaine and bupivacaine.
Methods: The medical records of cases, who underwent surgery for the repair of the inguinal hernia and undescended testis using ultrasound-guided TAP block in the department of pediatric surgery, were retrospectively reviewed (28 cases). The study included ASA I-II pediatric cases aged 2-12 years. The amount of drug administered while performing USG-guided TAP block, time to first analgesic use in the postoperative period, pain score and the amount of first analgesic administration were recorded. The satisfaction of the surgeon and patient’s companion was evaluated.
Results: A p-value <0.05 was considered statistically significant. The findings showed that pain score was the lowest in the group with the highest patient’s companion and physician satisfaction score, and the highest in group with the lowest satisfaction score and the difference was statistically significant (p<0.001). The satisfaction of the physicians (p=0.010) and the patient’s companion (p=0.027) increased with increasing drug volume.
Conclusions: The volume of 0.4 ml.kg-1 (50:50 1% lidocaine and 2.5% bupivacaine) achieved the best physician and patient’s companion satisfaction and the longest duration of analgesia in pediatric cases undergoing surgery for the repair of the inguinal hernia and undescended testis. The lack of any complications in the present study suggests that USG-guided TAP block is a safe procedure in pediatric patients in experienced hands. Further studies are required.
Relationship of Total Antioxidant Capacity and Endothelin-1 levels in prehypertensive individuals among population attaining a sedentary lifestyle in central India
Authors: Saxena Tripti , Naz Sabiha 
Published: February 2025

Objective: As known, hypertension has relation with increased peripheral vascular resistance. Vascular tone is regulated by multiple mediators; among them is Endothelin-1. Endothelin-1 (ET-1) is one of the most potent vasoconstrictors known to date. While its plasma /serum concentrations are elevated in some forms of hypertension. Prehypertension is one step towards hypertension, hence the same factor is involved in it. Oxidative stress is also found to be involved in pathogenesis of hypertension .Therefore our present study is designed to find the relationship between ET-1 levels and Total antioxidant capacity (TAC) in Prehypertension.
Methods: Total 100 prehypertensive cases and 100 sex matched controls were enrolled in this study. Inclusion criteria include patients with systolic blood pressure (SBP) in the range of 120 to 139 mmHg and diastolic blood pressure (DBP) in the range 80-90 mmHg, while patients with BP ≥140/90 mmHg, diabetes mellitus (DM), Stroke, coronary artery disease (CAD) and myocardial infarction (MI) were excluded. Plasma ET -1 and plasma total antioxidant capacity were measured .We estimated ET -1 levels and TAC levels in Prehypertensive cases and Normotensive controls. Students T test were used for statistical analyses.
Results: Plasma ET-1 levels were found significantly (p:0.001) higher in prehypertensive cases as compared to normotensive controls. In contrary to this, Plasma Total Antioxidant capacity was found extremely significantly lower in prehypertensive cases as compared to normotensive controls(p<0.0001).
Conclusion: The study demonstrated that in Prehypertensives, there is an inverse relationship between Endothelin-1 and Total antioxidant capacity.
An investigation of inappropriate medication use and dangerous drug combinations in elderly patients with polypharmacy
Authors: Baltacioglu Huseyin , Eroglu Oguz , Coskun Figen 
Published: February 2025

Objective: Polypharmacy is common among the elderly patients. The aim of this study was to determine drugs used inappropriately in elderly with polypharmacy or causing a dangerous drug combination (DDC) and to investigate the relation between drug interaction and emergency department (ED) presentation symptoms.
Methods: This prospective study was performed with elderly patients aged over 65. Patients’ demographic characteristics, presentation symptoms, comorbid diseases, and the names, numbers, dosages and side-effect of drugs used were recorded.
Results: DDC was present in 94.6% of patients, and 24.3% presented to the ED with drug interaction-related symptoms. The mean age of the patients with DDCs was 72.4±6.7 years, 68.3±5.5 years among those without DDC(p=0.016).The most common comorbid disease was hypertension(75.1%), the most commonly used drug group was anti arrhythmics (15.4%),and the most commonly used medication was aspirin(6.5%). The relation was observed between drug interaction-related presentation symptoms and coronary artery disease (CAD) (p=0.044). Correlation was determined between DDC and the anti-hypertensive drug group (p<0.001).Correlation was determined between drug interaction and subjects with presentation symptoms of dyspnea and bleeding (p<0.001 and p<0.001, respectively). Numbers of drugs used and frequency of presentation to hospital were higher in patients with DDCs (p<0.001; 0.040 respectively).Positive correlation was determined between frequency of presentation and number of drugs used(r: 0.514; p <0.001).
Conclusion: DDCs are more common as age increases in elderly. This situation especially remarkable in subjects with CAD and antihypertensive drugs users. Presentations to hospital caused by drug-drug interactions most commonly involve dyspnea and bleeding, and a higher number of drugs increase rates of DDC development and numbers of hospital presentations.
Investigation of antibiotic susceptibility profile and minimal inhibitor concentration changes in Pseudomonas aeruginosa isolates that exposed to subinhibitory concentrations of antibiotic
Authors: Kilinc Cetin , Guckan Ridvan , Coskun Umut Safiye Say 
Published: February 2025

Objective: During antibiotic use some of the bacteria in our flora can be affected by the used antibiotic in subinhibitory concentrations in addition to pathogenic microorganisms. The aim of this study to investigate in-vitro effects of subinhibitory concentrations antibiotic on antibiotic susceptibility profile of P.aeruginosa which can be found in normal flora and be a pathogenic bacteria.
Material and Method: The antibiotic effective concentrations decrease with distance from the antibiotic disc and growth-inhibition zone ends with the effect of the antibiotic falls to subinhibitory concentrations; and growth starts.We accepted this growth starting region as the area in which bacteria exposed to subinhibitory concentrations of antibiotic are located and we developed a model. We separetely exposed the standard P.aeruginosa strain to eight different antibiotics (amikacin, gentamicin, imipenem, meropenem, ceftazidime, cefepime, ciprofloxacin, colistin) for seven days in subinhibitory concentrations. P. aeruginosa strain is susceptible to these antibiotics and we monitored susceptibility and minimal inhibitor concentration changes. Moreover, we also made these procedures in 20 different clinical P.aeruginosa isolates.
Results: We observed that a resistance was developed in the standard P. aeruginosa strain starting second day of meropenem exposure, third day of ceftazidime exposure, fifth day of amikacin exposure and sixth day of gentamicin exposure. There was no resistance development after colistin, cefepime, ciprofloxacin, meropenem exposure but significant MIC value increases were detected. This resistance was not only against exposed antibiotic or antibiotic group but also against antibiotics in different antibiotic groups.
Conclusion: It was shown that especially subinhibitory concentrations using carbapenem and aminoglycoside antibiotics triggered resistance development against themselves more than other antibiotic groups. Use of colistin was not shown to cause cross resistance.
Strain Index Values in the Ultrasonographic Evaluation of Psoriasis
Authors: Menzilcioglu Mehmet Sait , Çitil Serdal , Akman Yasemin , Tüten Fatih 
Published: February 2025

Objective: Psoriasis is a widespread, chronic, recurrent, inflammatory disease of the skin which affects men and women equally. Elastography is a novel technique which uses the elasticity of the lesion. The aim of this study is to determine the elastographic findings of dermal psoriasis. This is the first study to evaluate SI in psoriasis patients and SI is helpful to evaluate psoriasis patients. We suggest that determining cut-off SI values for normal and dermal psoriasis can be helpful in the early diagnosis and follow-up of psoriasis patients.
Materials and Methods: This prospective study included a total of 21 (10 females, 11 males) healthy volunteers and 32 (17 females, 15 males) psoriasis patients between 2015 and 2016. An Aplio 500 ultrasound device (Toshiba Medical Systems Corp., Otawara, Japan) and a 5-13 MHz linear transducer were used for ultrasonographic and ultrasound elastographic examinations. The measurements were made from the flexor sides of upper and lower extremities. At least three measurements were performed for each lesion and strain index (SI) values were recorded
Results: The median SI values of healthy volunteers and psoriasis were 1.25 (0.16-8.00) (interquartile range (IR) 1.50) and 2.73 (0.43-13.32) (IR 3.39), respectively, indicating a significant difference between the groups (p: 0.001).
Conclusion: Our study results showed that the SI values of the dermis in psoriasis patients were significantly higher than those of healthy volunteers. We suggest that determining cut-off SI values for normal and dermal psoriasis can be helpful in the early diagnosis and follow-up of psoriasis patients. Advances in Knowledge: Due to the literature search, this is the first study to evaluate SI in psoriasis patients and SI is helpful to evaluate psoriasis patients.
McArdle's disease in a Turkish woman due to an intronic variant of PYGM gene
Authors: Diniz Gülden , Çelik Canan , Dikbaş Oğuz , Duman Aslıhan , Nursal Ayşe Feyda 
Published: February 2025

Objective: Glycogen storage disease type 5, also known as McArdle disease, is a hereditary disorder with progressive myopathy. It is characterized by onset of exercise intolerance with premature fatigue and painful muscle cramps in childhood or adolescence. Temporary myoglobinuria may occur after exercise due to rhabdomyolysis. Patients may have mild muscle weakness since childhood. Muscular atrophy with fatty replacement may develop in adult life. McArdle disease is a relatively benign disease and rarely severe myoglobinuria can cause acute renal failure as a complication of widespread rhabdomyolysis. This autosomal recessive disease is caused a homozygous mutation of the PYGM gene encoding muscle enzyme myophosphorylase C.
Case: A 36-year-old woman admitted to the Physical Medicine and Rehabilitation polyclinic of Giresun University Hospital with a complaint of gradually increasing progressive weakness and tiredness since 13 years age. CK serum level has been found to in normal range; even after exercise. The findings demonstrated myogenic abnormalities on electromyography, multiple glycogen-containing vacuoles and undetectable muscle myophosphorylase activity on muscle biopsy. The genetic analysis revealed no pathogenic mutations in exon regions of PYGM gene. But in sequencing analysis, the rs71049658, insertion/ deletion variation in intron 17 was determined. Coenzyme Q10 (CoQ-10) 30mg/day, vitamin B6 250mg/day and L-carnitine 1gr/day treatment protocol has been applied and after two months the treatment, clinical improvement has been achieved.
Conclusion: In this case report, an atypical McArdle case with a diagnostic challenge has been presented. We thought that this polymorphism in the myophosphorylase gene may lead to a severe mosaic alteration in mRNA splicing, including exon skipping, activation of cryptic splice-sites, and exon-intron reorganizations.
Acquired von Willebrand disease in chronic myeloproliferative disorders: a prospective single-center study
Authors: Ekinci Ömer , Aslanboğa Muhammed 
Published: February 2025

Objective: The rate of acquired von Willebrand disease (aVWD) among myeloproliferative patients is substantial enough to merit serious consideration, as it is thought to play a role in hemorrhage. We aimed to investigate the rate of acquired von Willebrand disease (aVWD) in chronic myeloproliferative disorders (MPD)
Materials and Methods: The present study was conducted prospectively on 70 patients admitted to hematology clinic. Complete blood count, PT, aPTT, vWF:Ag level, vWF:RCoF test, and factor VIII levels were analyzed for all patients. A finding of vWF:RCoF / Ag < 0.7 was accepted as the predisposition to aVWD.
Results: Of the patients, 33 (47.1%) were male, 37 (52.8%) were female, and the mean age was 50 ± 16.25. We detected aVWD in 19 (vWF:RCoF / Ag test < 0.7) (28%) of the 70 patients in the study group. Predisposition to aVWF was present in 7 of the 16 patients in the ET group(43.7%), in 4 of the 11 PV patients (36%), and in 8 of the 43 CML patients (18.6%). There was no statistically significant difference in the presence of aVWD between the three disease groups (p: 0.079).
Conclusion: The underlying mechanism of aVWD is still not fully resolved. Myeloproliferative diseases are one of the few diseases that can cause avWS. It should be kept in mind that aVWD may play a role in pathogenesis in people with chronic myeloproliferative disease, especially in cases of hemorrhage occurring in ET and PV patients.
Investigating demographic, socioeconomic, and obsteric risk factors of term intrauterine stillbirth cases
Authors: Kafadar Özgül Oğuz , Tekin Özlem Moraloğlu , Çoşkun Buğra , Özgür İrem Güler , Çoşkun Bora 
Published: February 2025

Objective: To establish the prevalence, etiology, demographic, socioeconomic, and obstetric risks factors of intrauterine fetal deaths among term pregnancies with no risk factors. Our study is the first to investigate term stillbirth risk factors in such a large population.
Material and Methods: A total of 96 cases of stillbirth between 37th and 42nd weeks with no risk factors out of 90,557 births conducted in 2011-2015 were investigated retrospectively. Eighty patients that had stillbirth in our clinic were chosen as the study cases and 80 others that had risk-free live birth at the weeks of 37-42 chosen randomly accepted as the control group. Variables such as age of mothers, gravidas, parities, level of education of mothers, time since the previous pregnancy, BMIs, weight gained during pregnancy, gestational week, birth weights of infants, systolic and diastolic blood pressures, hemoglobin values, blood glucose levels, white blood cell counts, smoking history, follow-ups at the hospital, gender of babies, and seasonal distribution of stillbirths were evaluated.
Results: The stillbirth rate was found as 14 per million and stillbirth in risk-free population at 37-42 weeks was 1.05 per mill. BMI, hemoglobin levels, and systolic blood pressures of mothers were significantly higher in stillbirths. Any statistically significant difference in mean maternal age, gravida/parity, education level, weight gained during pregnancy, smoking and fetal gender distribution was not established between the groups
Conclusion: Term stillbirths in the risk-free group may be correlated with advanced gestational week, increased BMI, systolic blood pressure, and hemoglobin levels of the mother also insufficient antenatal follow-up.
Manejo Neurocirúrgico de Traumatismos Cranioencefálicos Graves em Crianças na Emergência
Authors: Ceschini Nádia , Floriano Caroline Hernandes Ferreira , Godinho Breno Veggi , Bersaghi Gustavo Paraboni , Mello Bruna Regina Marinho de , Queiroz Vinicius Kaiser , Comparim Eduardo José , Filho Jackson ferreira de Souza Santos , Gonçalves Túlio César , Bellaver Leticia Massoco Rios , Raposo Carla Weruska De Lourdes Cangello , Tavares Rafael barrueco , Vieira Almir Fernandes Simões , Freitas João Henrique Affiune de , Prado Giovanna de Castro do Amaral Monteiro 
Published: February 2025

Resumo
Introdução: Os traumatismos cranioencefálicos (TCEs) são uma das principais causas de morbidade e mortalidade em crianças. O manejo correto é fundamental para melhorar os desfechos neurológicos. Classificação da Gravidade: Utilização da Escala de Coma de Glasgow (ECGl) para determinar a gravidade da lesão. - ECGl entre 13-15: leve- ECGl entre 9-12: moderado ECGl entre 3-8: grave. Por isso vamos poder analisar os dados em especial em TCEs graves. Medidas incluem elevação da cabeceira, controle da sedação, e uso de diuréticos osmóticos como o manitol.
Este estudo visa analisar a epidemiologia do traumatismo cranioencefálico na população jovem brasileira entre os anos de 2012 e 2022. Métodos: Foi realizado um estudo descritivo-analítico utilizando dados do DATASUS sobre traumas intracranianos em pessoas de 0 a 11 anos no Brasil nesse período. Resultados: Foram registradas 247.116 internações, que resultaram em 8.936 mortes, totalizando uma taxa de mortalidade de 3,61%, com um custo médio de R$266,30 por dia e um tempo de internação de 4,2 dias. O perfil epidemiológico dos pacientes com trauma intracraniano são predominantemente homens pardos na faixa etária de 15 a 19 anos, principalmente oriundos da região sudeste. Discussão: A morbidade e mortalidade em jovens é mais acentuada entre os 15 e 19 anos, com elevados custos hospitalares devido a intervenções clínico-cirúrgicas para tratar infecções ou realizar drenagens de hematomas intracerebrais. O custo relacionado ao tratamento pós-hospitalar é pouco discutido, sendo ligado ao cuidado com sequelas, à prevenção de novas lesões e ao acompanhamento multidisciplinar especializado. Conclusões: O trauma intracraniano em jovens representa uma questão relevante em nossa sociedade, implicando em prejuízos sociais e funcionais, além de um número considerável de óbitos. Portanto, é crucial desenvolver ações preventivas voltadas para a redução desses eventos traumáticos.