bluuebunny/crossref_metadata_2025_split huggingface dataset:
The value of neutrophil-to-lymphocyte ratio in predicting severity of coronary involvement and long-term outcome of percutaneous coronary intervention in patients with acute coronary syndrome: a systematic review and meta-analysis
Authors: Shahsanaei Farzad , Abbaszadeh Shahin , Behrooj Soudabeh , Rahimi Petrudi Nima , Ramezani Bahareh 
Published: March 2024

Abstract
Background
The value of counting inflammatory cells and especially their counting ratio in predicting adverse clinical outcomes in patients with acute coronary syndrome (ACS) undergoing revascularization has been shown, but the results of studies have been very diverse and paradoxical. The aim of the current study was to systematically review the studies that investigated the role of increased neutrophil-to-lymphocyte ratio (NLR) in predicting long-term clinical outcomes in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI).

Methods
Data abstraction was independently performed by both un-blinded reviewers on deeply assessing Medline, Web of Knowledge, Google Scholar, Scopus, and Cochrane Central Register of Controlled Trials and using the relevant keywords. The risk of bias for each study was assessed using the criteria outlined in the Cochrane Handbook for Systematic Reviews of Interventions and the QUADAS-2 tool. Statistical analysis was performed using the Stata software. Overall, 14 articles published between 2010 and 2021 were eligible for the final analysis.

Results
A total of 20,846 ACS patients undergoing PCI were included. Higher values of NLR were associated with higher numbers of involved coronaries (RR: 1.175, 95%CI 1.021–1.353, P = 0.024). Increasing the value of NLR was associated with a 3.4 times increase in long-term death (RR: 3.424, 95%CI 2.325–5.025, P = 0.001). Similarly, higher values of NLR were significantly associated with a higher likelihood of long-term MACE (RR: 2.604, 95%CI 1.736–3.906, P = 0.001).

Conclusions
NLR has a high value in predicting both the severity of coronary artery involvement and long-term adverse clinical outcomes following the PCI procedure.
Oxaliplatin-Based Adjuvant Chemotherapy in Older Patients With Stage III Colon Cancer: An ACCENT/IDEA Pooled Analysis of 12 Trials
Authors: Gallois Claire , Shi Qian , Pederson Levi D. , André Thierry , Iveson Timothy J. , Sobrero Alberto F. , Alberts Steven , de Gramont Aimery , Meyerhardt Jeffrey A. , George Thomas , Schmoll Hans-Joachim E. , Souglakos Ioannis , Harkin Andrea , Labianca Roberto , Sinicrope Frank A. , Oki Eiji , Shields Anthony F. , Boukovinas Ioannis , Kerr Rachel , Lonardi Sara , Yothers Greg , Yoshino Takayuki , Goldberg Richard M. , Taieb Julien , Papamichael Demetris 
Published: March 2024

PURPOSE A number of studies suggest that older patients may have reduced or no benefit from the addition of oxaliplatin to fluoropyrimidines as adjuvant chemotherapy for stage III colon cancer (CC). MATERIALS AND METHODS We studied the prognostic impact of age, as well as treatment adherence/toxicity patterns according to age, in patients with stage III CC who received 3 or 6 months of infusional fluorouracil, leucovorin, and oxaliplatin/capecitabine and oxaliplatin (CAPOX) on the basis of data collected from trials from the ACCENT and IDEA databases. Associations between age and time to recurrence (TTR), disease-free survival (DFS), overall survival (OS), survival after recurrence (SAR), and cancer-specific survival (CSS) were assessed by a Cox model or a competing risk model, stratified by studies and adjusted for sex, performance status, T and N stage, and year of enrollment. RESULTS A total of 17,909 patients were included; 24% of patients were age older than 70 years (n = 4,340). Patients age ≥70 years had higher rates of early treatment discontinuation. Rates of grade ≥3 adverse events were similar between those older and younger than 70 years, except for diarrhea and neutropenia that were more frequent in older patients treated with CAPOX (14.2% v 11.2%; P = .01 and 12.1% v 9.6%; P = .04, respectively). In multivariable analysis, TTR was not significantly different between patients <70 years and those ≥70 years, but DFS, OS, SAR, and CSS were significantly shorter in those patients ≥70 years. CONCLUSION In patients ≥70 years with stage III CC fit enough to be enrolled in clinical trials, oxaliplatin-based adjuvant chemotherapy was well tolerated and led to similar TTR compared with younger patients, suggesting similar efficacy. TTR may be a more appropriate end point for efficacy in this patient population.
Clay
Authors: Newell Penny Harvey 
Published: March 2024

Abstract
What is the ontologizing effect of a care framework? And how can clay cease to insist on itself as an abstracted medium of self-making? The artists Jade Montserrat, Chinasa Vivian Ezugha, and Cassils each work clay as a material in their performance. Their toil of working with this organic material signals to the work of self-care as maintenance and ecological maintenance, a sign of the forces of reproduction that may befall marginalized people and communities within the collective care of the earth. Drawing up an analysis of the maintenance work of these three clay performances, this article builds toward an ecocritical framework that takes account of the literal dimensions of what might otherwise fall into the trappings of an abstract, conceptual affinity. That is, existing as conceptually closer to nonhuman nature carries duties and responsibilities, labor and toil, burdens of care, self-care, maintenance, and the sweaty, untidy, unraveling, by nature always unfinished work of recovery. The article explores a notion of transactional care, asking after the distributed ontologizing effect, the widened field of enclosure, and the matrices of legibility that earth-care paradigms might afford.
Anticholinergic toxidrome due to thorn apple seed ingestion in an elderly couple
Authors: van Gastel Pepijn , Dijkstra Jildou N. , Jacob Mina A. , Schouten Jeroen A. , Kok Bram 
Published: March 2024

Introduction: Sudden onset of reduced consciousness, psychomotor agitation and mydriasis are all indicative of an anticholinergic toxidrome. It is important to note that numerous drugs, as well as certain herbs and plants, possess anticholinergic properties. Case description: An 84-year-old female patient had sudden nocturnal onset of uncoordinated hand movements and altered mental status. Shortly after, the patient’s 83-year-old husband developed symptoms of dysarthria, gait ataxia, vertigo, and delirium. Conclusion: Anticholinergic syndrome consists of a combination of central and peripheral anticholinergic symptoms. Physostigmine given intravenously resulted in rapid reversal of symptoms. Thorn apple seeds had been accidentally ingested and were identified as the cause.
Promotion of anti-values in social media discourse – a threat to the proper functioning of society
Authors: Banaszak Artur 
Published: March 2024

ObjectivesThe main subject of this article is the harmful influence of some content of social media and the threat related to this content. The research hypothesis is given, that social media are promoting anti-values which may be harmful for society and therefore, some action should be taken to prevent this situation. Article discusses such issues as values and anti-values, the phenomenon of influencer. Some examples of harmful content given by social media also are presented.Material and methodsArticle discusses such issues as values and anti-values, the phenomenon of influencer. Some examples of harmful content given by social media also are presented. The main research method used in this article is the analyzes of different content of social media.ResultsThe result is to show the some social media content can be the destructive and bring threats to proper finctioning of society.ConclusionsThe conclusion of the article is that there is a need and even an obligation to fight with the promotion of those anti-values also on legal ground.
Implementation and Challenge of Supported Employment for People With Disabilities in China
Authors: Gong Yan , Xu Su Qiong 
Published: March 2024

Abstract
The Chinese government initiated a pilot program to implement supported employment for people with disabilities in 2014. Since then, policies have been enacted to promote supported employment. This study explored how practitioners understand and implement supported employment for people with disabilities in China. It was found that non-governmental service organizations have mainly implemented supported employment with financial support provided by local disabled persons’ federations; without a governmental guide, the small-scale folk practice presented many difficulties and unstable factors. Results indicated that the Chinese government should actively establish and improve the supported employment system and further expand supported employment practices at the governmental level.
Healthy Nutrition for Adults With Intellectual Disability: Piloting a Mobile Health Application and Self-Management Intervention
Authors: Savage Melissa N. , Candelaria Alexandra E. 
Published: March 2024

Abstract
While there are many benefits to healthy nutrition, adults with intellectual disability often have poor nutrition habits. The purpose of this pilot study was to examine the use of a nutrition app and self-management intervention to increase awareness of healthy nutrition choices for adults with intellectual disability. Data was gathered on the effectiveness of the intervention and social validity of intervention components. Through a single-case multiple-baseline across participants design, the mobile nutrition app with self-management intervention was effective in increasing awareness of healthier nutrition items for three adults with an intellectual disability. Future research is needed to replicate and generalize findings, as well as explore additional supports that may be needed for individuals who have more extensive support needs.
Outcomes for Adults With Intellectual and Developmental Disabilities Receiving Long-Term Services and Supports: A Systematic Review of the Literature
Authors: Carlson Sarah R. , Munandar Vidya , Thompson James R. 
Published: March 2024

Abstract
The impact of long-term services and supports on the quality of life of adults with intellectual and developmental disabilities (IDD) is not well understood given the highly complex nature of researching this topic. To support future research addressing this topic, we conducted a systematic literature review of studies addressing outcomes of adults with IDD receiving long-term services and supports. Results of this review describe current outcomes for adults with IDD who receive long-term services and supports and can be used to inform program evaluation, policy development, and future research.
Horizontal free-space optical link with CubeISL over 143  km
Authors: Nonay Jorge Rosano , Rüddenklau René , Sinn Andreas , Jakobs Jan Paul , Berlitz Jonas , Rödiger Benjamin , Schitter Georg 
Published: March 2024

Recent advancements in free-space optical (FSO) communications are enabling a breakthrough in satellite miniaturization and data transfer rates. The CubeISL laser communication terminal (LCT), a development of the German Aerospace Center (DLR), is set to showcase inter-satellite links at 100 Mbps and downlinks at 1 Gbps once it launches in 2025. This technology aims to establish itself as the cutting-edge solution for efficient CubeSat communications, delivering high data rates. To validate its capabilities, the terminal underwent rigorous testing in a 143 km FSO link between the astronomical sites of La Palma and Tenerife in the Canary Islands. The European Space Agency’s Optical Ground Station emulated downlinks, while the communication between two LCTs simulated inter-satellite links. This paper outlines the current developmental stage of the CubeISL LCT and presents the outcomes of its horizontal link demonstration.
Mid-infrared interferometry with non-adiabatic tapered ZBLAN optical fiber
Authors: Anelli Francesco , Annunziato Andrea , Loconsole Antonella Maria , Francione Vito Vincenzo , Cozic Solenn , Poulain Samuel , Prudenzano Francesco 
Published: March 2024

This work illustrates, to the best of our knowledge, the first non-adiabatic tapered single-mode zirconium fluoride optical fiber sensor in the mid-infrared spectral range. It is designed and fabricated via pulling and heating technique. A waist diameter d
w
= 25 µm with no visible crystallization is achieved, overcoming the typical fluoride glass challenges associated with crystallization, narrow temperature fabrication window, and low glass transition temperature. The performance of the non-adiabatic tapered optical fiber is theoretically and experimentally investigated, demonstrating its high potential for a wide range of sensing applications in the mid-infrared spectral range.
Impact of the UK soft drinks industry levy on health and health inequalities in children and adolescents in England: An interrupted time series analysis and population health modelling study
Authors: Cobiac Linda J. , Rogers Nina T. , Adams Jean , Cummins Steven , Smith Richard , Mytton Oliver , White Martin , Scarborough Peter 
Published: March 2024

Background
The soft drinks industry levy (SDIL) in the United Kingdom has led to a significant reduction in household purchasing of sugar in drinks. In this study, we examined the potential medium- and long-term implications for health and health inequalities among children and adolescents in England.

Methods and findings
We conducted a controlled interrupted time series analysis to measure the effects of the SDIL on the amount of sugar per household per week from soft drinks purchased, 19 months post implementation and by index of multiple deprivation (IMD) quintile in England. We modelled the effect of observed sugar reduction on body mass index (BMI), dental caries, and quality-adjusted life years (QALYs) in children and adolescents (0 to 17 years) by IMD quintile over the first 10 years following announcement (March 2016) and implementation (April 2018) of the SDIL. Using a lifetable model, we simulated the potential long-term impact of these changes on life expectancy for the current birth cohort and, using regression models with results from the IMD-specific lifetable models, we calculated the impact of the SDIL on the slope index of inequality (SII) in life expectancy. The SDIL was found to have reduced sugar from purchased drinks in England by 15 g/household/week (95% confidence interval: −10.3 to −19.7). The model predicts these reductions in sugar will lead to 3,600 (95% uncertainty interval: 946 to 6,330) fewer dental caries and 64,100 (54,400 to 73,400) fewer children and adolescents classified as overweight or obese, in the first 10 years after implementation. The changes in sugar purchasing and predicted impacts on health are largest for children and adolescents in the most deprived areas (Q1: 11,000 QALYs [8,370 to 14,100] and Q2: 7,760 QALYs [5,730 to 9,970]), while children and adolescents in less deprived areas will likely experience much smaller simulated effects (Q3: −1,830 QALYs [−3,260 to −501], Q4: 652 QALYs [−336 to 1,680], Q5: 1,860 QALYs [929 to 2,890]). If the simulated effects of the SDIL are sustained over the life course, it is predicted there will be a small but significant reduction in slope index of inequality: 0.76% (95% uncertainty interval: −0.9 to −0.62) for females and 0.94% (−1.1 to −0.76) for males.

Conclusions
We predict that the SDIL will lead to medium-term reductions in dental caries and overweight/obesity, and long-term improvements in life expectancy, with the greatest benefits projected for children and adolescents from more deprived areas. This study provides evidence that the SDIL could narrow health inequalities for children and adolescents in England.
Association between sociodemographic factors, clinic characteristics and mental health screening rates in primary care
Authors: Müller Frank , Abdelnour Alyssa M. , Rutaremara Diana N. , Arnetz Judith E. , Achtyes Eric D. , Alshaarawy Omayma , Holman Harland T. 
Published: March 2024

Background
Screening for mental health problems has been shown to be effective to detect depression and initiate treatment in primary care. Current guidelines recommend periodic screening for depression and anxiety. This study examines the association of patient sociodemographic factors and clinic characteristics on mental health screening in primary care.

Design
In this retrospective cohort study, electronic medical record (EMR) data from a 14-month period from 10/15/2021 to 12/14/2022 were analyzed. Data were retrieved from 18 primary care clinics from the Corewell Health healthcare system in West Michigan. The main outcome was documentation of any Patient Health Questionnaire (PHQ-4/PHQ-9/GAD-7) screening in the EMR within the 14-month period at patient level. General linear regression models with logit link function were used to assess adjusted odds ratio (aOR) of having a documented screening.

Results
In total, 126,306 unique patients aged 16 years or older with a total of 291,789 encounters were included. The prevalence of 14-month screening was 79.8% (95% CI, 79.6–80.0). Regression analyses revealed higher screening odds for patients of smaller clinics (<5,000 patients, aOR 1.88; 95% CI 1.80–1.98 vs. clinics >10.000 patients), clinics in areas with mental health provider shortages (aOR 1.69; 95% CI 1.62–1.77), frequent visits (aOR 1.80; 95% CI, 1.78–1.83), and having an annual physical / well child visit encounter (aOR 1.52; 95% CI, 1.47–1.57). Smaller positive effect sizes were also found for male sex, Black or African American race, Asian race, Latinx ethnicity (ref. White/Caucasians), and having insurance through Medicaid (ref. other private insurance).

Discussion
The 14-month mental health screening rates have been shown to be significantly lower among patients with infrequent visits seeking care in larger clinics and available mental health resources in the community. Introducing and incentivizing mandatory mental health screening protocols in annual well visits, are viable options to increase screening rates.
Older women’s experience with COVID-19 pandemic: A study of risk perception and coping among culturally and linguistically diverse population in South Australia
Authors: Siddiquee Noore Alam , Hamiduzzaman Mohammad , McLaren Helen , Patmisari Emi 
Published: March 2024

Background
A global catastrophe–the COVID-19 pandemic–appears to have two-dimensional health consequences for older adults: high risk of being infected and psychological distress. There is limited evidence on how the pandemic has impacted the life and coping of older adults who are culturally and linguistically diverse (CALD), women in particular. This study explored the COVID-19 risk perception and coping strategies of older CALD women in South Australia.

Methods
A mixed-methods research design was employed, involving a 31-items coping and emergency preparation scale for survey and semi-structured interviews with participants. The older CALD women were approached through 11 multicultural NGOs. One hundred and nine women participants from 28 CALD communities completed the online surveys; 25 of them agreed to a telephone interview and provided their contact details. 15 older CALD women ultimately participated in interviews.

Results
Mean sum-score of dread risk, unknown risk, and fear (M: 43.5; SD: 4.9) indicated that the participants were somewhat anxious and worried. Mean sum-score of coping (M: 79.8; SD: 9.3) reported their compliance with expert advice and disinfection practices but accessing health information (M: 2.8; SD 1.4) and tendency to minimize anxiety (M: 2.1; SD: 1.2) were below neutral. Significant variations were found in coping in terms of age, meaning that the women aged 75 years and older were less likely to cope with the pandemic (P = 0.01). Emergency preparation differed based on the participants’ residence and occupation status. The deductive-inductive thematic analysis of interview data was framed around three priori themes: risks of being affected, emotional and behavioral coping, and emergency preparation and access to services.

Conclusions
Evidence shows a fear among the older CALD women with an endeavor to cope and prepare for emergency situations. This suggests the requirements for interventions that improve coping and reduce the risk of stress among them.
Acute Pancreatitis Revealing a Diagnosis of Diffuse Large B-Cell Lymphoma
Authors: Herman Tessa , Wilson Natalie , Abdallah Mohamed , Bilal Mohammad , Nemat Hashim 
Published: March 2024

ABSTRACT
Acute pancreatitis is a common gastroenterological condition that can occur due to several causes. While not required for diagnosis, imaging is often performed and may reveal unexpected findings such as pancreatic masses. Malignancies such as lymphoma are uncommon causes of acute pancreatitis, especially as the initial presentation of malignancy. We present a case of a young patient with acute pancreatitis caused by diffuse large B-cell lymphoma with extranodal disease secondarily involving the pancreas. Our case highlights the importance of keeping a broad differential for acute pancreatitis and considering rare etiologies such as pancreatic lymphoma in patients without another obvious culprit.
A multicenter study of maternal conditions and amniotic fluid volume in Ethiopia in 2023
Authors: Erega Besfat Berihun , Ferede Wassie Yazie , Sisay Fillorenes Ayalew , Ayalew Abeba Belay , Arage Rahel Birhanu 
Published: March 2024

AbstractThe amniotic fluid is a protective liquid found in amniotic found in the amniotic sac and mainly containing water and some solid substances including epitheloid and fibroblastic type cells. Most of the studies conducted about amniotic fluid volume (AFV) reported fetal and placental factors as a determinant of AFV. The aim of this study is to examine maternal and obstetric conditions in relation to AFV among women with term pregnancies. A multicenter institutional based cross‐sectional study was conducted among clients attending selected public hospitals of South Gondar Zone, Ethiopia from January 01, 2023 to May 30, 2023. The sample size was calculated by using the assumption of single population proportion formula considering the prevalence value of 50%, 95% confidence interval, and margin of error 5% and 10% non respondent rate. In our study rural residency AOR = 3.21 (1.19–5.37), chronic illness AOR = 2.12 (1.33–4.61), short inter pregnancy interval AOR = 3.03 (2.18–6.28), Hypermesis gravidarum AOR = 1.19 (1.02–4.41), and maternal diabetics AOR = 2.16 (1.32–4.75) had significant association with the outcome variable. These maternal conditions may be correlated with an abnormal volume of amniotic fluid.
Why Privation Is a Form in a Qualified Sense for Aristotle
Authors: Cummings-Coughlin Cara Rei 
Published: March 2024

Abstract
In Aristotle’s account of change, lacking a form is called privation (Physics I.7 191a14). For example, someone takes on the form of being musical only from previously having the privation of being unmusical. However, he also states that “shape and nature are spoken of in two ways, for the privation too is in a way form” (Physics II.1 193b19). I will demonstrate that these seemingly contradictory statements are not actually in tension. Since all perceptible matter must be enformed, we would have trouble discussing things that have yet to undergo generation, like menstrual fluid, and things that have undergone corruption, like corpses, if we did not cite the privation as a sort of form. I will argue that, given his commitment to hylomorphism, Aristotle is committed to privation being a form in a qualified sense. It cannot be a form in an unqualified sense because privation often spoils the matter such that it can no longer be reformed. The fact of the matter is we cannot draw a bright line between privation and form because the two are contraries and can be said to hold to different degrees at different points on a spectrum.