bluuebunny/crossref_metadata_2025_split huggingface dataset:
A one step method to prepare polymer‐based flexible wires by continuous spatial‐confining network assembly technique
Authors: Jiang Haohua , Li Nan , Li Chenglin , Zhu Yuanxiang , Gao Xiaolong , Xu Hong , Sun Jingyao , Zhao Zhongli , Wu Daming , Zheng Xiuting , Huang Yao 
Published: March 2024

AbstractIn recent years, flexible electronics technology has been developing rapidly, and flexible electronic devices have been widely used in wearable gadgets and robotics. Flexible wires are the basic components of these devices, which usually consist of metallic materials with flexibility and ductility. However, the introduction of flexible conductive materials has broadened the application scope of flexible wires. In this paper, PDMS/SCF conductive composites exhibiting different conductivity properties on both sides are fabricated by adding meshes based on the continuous spatial‐confining network assembly method. The conductivity of PDMS/SCF (6 wt%) composites can be exhibited as 173.45 S/m in the conductive layer and 6.25 × 10−11 S/m in the insulating layer, which can be used as core and surface layers of conductors, respectively. A mathematical model is also developed to predict the electrical conductivity of the PDMS/SCF conductive composites, and the experimental data are in good agreement with the predicted results. This work provides a method for the continuous preparation of multifunctional composites that can be molded in one step with conductive layer and insulating layer, which can be used as the core and insulating layers of wires, thus simplifying the preparation process of composite‐based wires and expanding the range of conductive composites applications.
UPLC–Q‐TOF/MS analysis of chemical components of single decoction and combined decoction of Qige decoction reveals the differences between various preparation processes
Authors: Guo Kai‐Xin , Yu Xiao‐Qing , Tang Hui , Wei Hao‐Yang , Li Yan‐Fang , Fan Si‐Min , Huang Ke‐Er , Ke Xue‐Hong 
Published: March 2024

AbstractThe aim of this work was to explore the differences between various pharmaceutical processes in combined solutions of a single decoction (QGHBY) and a combined decoction (QGHJY) of Qi‐Ge decoction from the perspective of chemical composition changes, so as to further guide the clinical application of drugs. A combined solution of a single decoction and a combined decoction of Astragali Radix, Puerariae Lobatae Radix and Citri Reticulatae Chachiensis Pericarpium was prepared with the same technological parameters. The chemical components of the two were detected and identified based on UPLC–Q‐TOF/MS, and the different components were determined by principal component analysis. Eighty‐eight compounds were identified in the pharmaceutical solution of Qi‐Ge decoction. Principal component analysis revealed 11 different components of QGHBY and QGHJY with the conditions of Variable Importance in Projection (VIP)  ≥ 1, fold change ≥ 2 and p < 0.05, among which hesperidin, hesperitin, isosinensetin, sinensetin and 5‐demethylnobiletin were the components of Citri Reticulatae Chachiensis Pericarpium. The levels of these 11 different components in QGHJY were higher than those of QGHBY. The combined decoction is beneficial for the dissolution of flavonoids and other chemical components, and there is a significant difference in the content of chemical components between modern herbal concentrate granules and traditional decoctions.
Group Radical Openness: Participants' attributions of change
Authors: Johnstone Violet , McDonough Cian , Egan Rachel , Browne Katie , Corbett Amy 
Published: March 2024

AbstractBackgroundGroup Radical Openness (GRO) has been shown to be a feasible and acceptable intervention for individuals who struggle with costly overcontrol. This paper explores participants' reports of attributions of change following the engagement in GRO.MethodFourteen participants took part in qualitative interviews. An adapted version of ‘The Revised Client Change Interview Schedule: Version 5’ was used to capture the experiences of change following the intervention (Elliott & Rodgers, 2008). Research participants were outpatients of a psychiatric hospital who attended GRO. The sample consisted of 14 participants (6 females: 8 males); mean age 44.4 years; and age range 18–58. All participants attended 26, 3‐h group sessions. Reflexive thematic analysis was used to identify the specific aspects of the group therapy to which clients attributed change.ResultsThe analysis identified three superordinate themes, each with two subthemes. These included Safety and Connection (Safety and Tribe; Open and Genuine Facilitation); Understanding Overcontrol (Awareness of Overcontrol; The GRO Approach); and Carrying GRO Forward (Increased Awareness and Capacity to Reflect; Internalising GRO).ConclusionGroup Radical Openness was shown to be an acceptable group therapy treatment for people with an overcontrolled coping style. This paper further clarifies the participants' experiences of GRO and what aspects led to change from their perspective.
Interdisciplinary full mouth rehabilitation of a patient with amelogenesis imperfecta from childhood to young adult‐hood: A 12‐year case report
Authors: Caussin Élisa , Courson Frédéric , Dursun Elisabeth , Brukarz Yohann , Dot Daniel , Chaussain Catherine , Attal Jean‐Pierre , François Philippe 
Published: March 2024

Key Clinical MessageTreatment of patients with amelogenesis imperfecta extends over many years, from childhood to early adulthood. Their management at any age is complex and has to be adapted in relation to therapies validated in the general population.
Diamine‐Assistant Synthesis of Cu@MFI Catalysts for Ethanol Dehydrogenation
Authors: Guo Jin , Pang Jifeng , Yin Ming , Feng Lele , Liu Shimin , Wu Pengfei , Zheng Mingyuan 
Published: March 2024

AbstractEncapsulation of metal particles into zeolites is an attractive strategy for stabilizing metal species. Nevertheless, most metal cations tend to precipitate under basic and hydrothermal conditions without the use of effective anchoring agents. Herein, low‐cost diamines of ethylenediamine and propanediamine were selected as effective chelators, which stabilized the Cu species under basic conditions and then anchored them into the framework of MFI (silicate‐1) during the hydrothermal process. The obtained Cu@MFI−R catalyst showed >96 % ethanol conversion and 98 % acetaldehyde selectivity in the 300 h time on stream, demonstrating superior advantages over the impregnation method prepared Cu/MFI catalysts. Characterization of Cu@MFI−R catalysts revealed that Cu nanoparticles were fixed in the framework of MFI, producing abundant Cu+ species for ethanol conversion. Additionally, the spatial confinement effects inhibited Cu+ reduction and aggregations, affording a high catalyst stability. Differently, over Cu/MFI catalysts, the unconfined Cu+ species were prone to be reduced into Cu0 during the reaction, resulting in the Cu particles aggregation and activity depression.
Structure‐Property Relationships for Potential Inversion From Electron Acceptors Based on Thiophene‐Fused Triptycene Quinones, 1,4‐Diketones and Their Malononitrile Adducts
Authors: Warrington Stefan , Montanaro Stephanie , Elsegood Mark R. J. , Nichol Gary S. , Wright Iain A. 
Published: March 2024

AbstractThe synthesis and properties of a series of 11,11,12,12‐tetracyano‐9,10‐anthraquinodimethane (TCAQ) inspired electron acceptors based on thiophene‐fused quinone and triptycene motifs is presented. This has yielded insights into structure‐property relationships for establishing and modulating simultaneous two‐electron reduction processes in TCAQ analogues. These new compounds were synthesised using a Friedel‐Crafts acylation between triptycene and thiophene‐3,4‐dicarbonyl chloride. Isomeric para‐quinones featuring a [c]‐fused thiophene on one side and a β,β‐ or α,β‐fused triptycene on the other were isolated alongside a thiophene‐3,4‐diketone which bears two triptycene fragments. Knoevenagel condensation of these products with malononitrile produced a quinoidal bis(dicyanomethylene), an oxo‐dicyanomethylene and an acyclic bis(dicyanomethylene). This series of new electron accepting molecules has been studied using X‐ray crystallography and the implications of their 3D structures on NMR and UV/vis absorbance spectroscopy and cyclic voltammetry results have been ascertained with conclusions underpinned by computational methods.
Phosphine‐Catalyzed Synthesis and Cytotoxic Evaluation of Michael Adducts of the Sesquiterpene Lactone Arglabin
Authors: Salin Alexey V. , Shabanov Andrey A. , Khayarov Khasan R. , Islamov Daut R. , Voloshina Alexandra D. , Amerhanova Syumbelya K. , Lyubina Anna P. 
Published: March 2024

AbstractA general method for chemo‐ and diastereoselective modification of anticancer natural product arglabin with nitrogen‐ and carbon‐centered pronucleophiles under the influence of nucleophilic phosphine catalysts was developed. The locked s‐cis‐geometry of α‐methylene‐γ‐butyrolactone moiety of arglabin favors for the additional stabilization of the zwitterionic intermediate by electrostatic interaction between phosphonium and enolate oxygen centers, leading to the unprecedentedly high efficiency of the phosphine‐catalyzed Michael additions to this sesquiterpene lactone. Using n‐Bu3P as the catalyst, pyrazole, phthalimide, 2‐oxazolidinone, 4‐quinazolinone, uracil, thymine, cytosine, and adenine adducts of arglabin were obtained. The n‐Bu3P‐catalyzed reaction of arglabin with active methylene compounds resulted in the predominant formation of bisadducts bearing a new quaternary carbon center. All synthesized Michael adducts and previously obtained phosphorylated arglabin derivatives were evaluated in vitro against eleven cancer and two normal cell lines, and the results were compared to those of natural arglabin and its dimethylamino hydrochloride salt currently used as anticancer drugs. 2‐Oxazolidinone, uracil, diethyl malonate, dibenzyl phosphonate, and diethyl cyanomethylphosphonate derivatives of arglabin exhibited more potent antiproliferative activity towards several cancer cell lines and lower cytotoxicity towards normal cell lines in comparison to the reference compounds, indicating the feasibility of the developed methodology for the design of novel anticancer drugs with better therapeutic potential.
On the Statistical Regime, Coherence versus Incoherence and Ergodicity of Quantum Vibrational Trajectories in Soft Condensed Molecular Systems
Authors: Amadei Andrea , Aschi Massimiliano 
Published: March 2024

AbstractA theoretical‐computational procedure, recently proposed for modelling Vibrational Energy Relaxation (VER) processes of a molecule (Quantum Center, QC) embedded in a complex atomic‐molecular system, is extended and applied for analyzing in detail the features of the QC density matrix (DM) temporal evolution. The results, obtained using aqueous azide ion as a case study, show the total lack of coherence in the DM, when the system is prepared to be initially in a pure vibrational eigenstate. This finding is fully in line with the statistical interpretation of the process typically adopted also in the experimental studies where the relaxation processes are all described within the typical schemes of chemical kinetics. Consistently, when the initial vibrational state corresponds to an eigenstate mixture, although initially coherent, the DM relaxes to a fully incoherent condition with a mean lifetime related to the one of the diagonal elements relaxation. These specific DM features turn out to be essentially governed by the thermal equilibrium condition of the atomic‐molecular classical coordinates which drive the ensemble of the quantum‐trajectories toward the observed statistical regime. Finally, from the analysis of a single long timescale quantum vibrational trajectory it also clearly emerges its ergodic behaviour.
Codelivery of Gaseous Signaling Molecules for Biomedical Applications
Authors: Sheng Jiahui , Luo Siyuan , Zheng Bin , He Kewu , Hu Jinming 
Published: March 2024

AbstractGaseous signaling molecules (GSMs) including nitric oxide (NO), carbon monoxide (CO) and hydrogen sulfide (H2S) have presented excellent therapeutic efficacy such as anti‐inflammatory, anti‐microbial and anti‐cancer effects and multiple biomedical applications in recent years. As the three most vital signaling molecules in human physiology, these three GSMs show so intertwined and orchestrated interactions that the synergy of multiple gases may demonstrate a more complex therapeutic potential than single gas delivery. Consequently, researchers have been devoted to developing codelivery systems of GSMs by synthesizing a single molecule as a dual donor to maximize the gaseous therapeutic efficacy. In this minireview, we summarize the recent developments of molecules or materials enabling codelivery of GSMs for biomedical applications. It appears that compared with the abundant cases of codelivery of NO and H2S, research on codelivery of CO and the other two GSMs separately remains to be explored.
Novel statistical method for data drift detection in satellite telemetry
Authors: Praveen M. V. Ramachandra , kuchhal Piyush , Choudhury Sushabhan 
Published: March 2024

SummaryAutonomy is becoming a prime requirement for satellite mission control operations. Data‐driven methods like Machine Learning models are playing a key role in bringing in autonomy. Health keeping data from satellite telemetry is a key ingredient in these data‐driven methods. In real‐world satellite operations, the health‐keeping telemetry data gradually drifts due to adverse space weather effects and wear and tear of electronic and mechanical components. The key question that arises is how to detect and quantify the data drift which is generally a gradual phenomenon. This paper discusses a novel statistical method for detecting data drift occurring in satellite telemetry. For the purpose of experimental work in this paper, an actual telemetry data set of the BUS CURRENT sensor which is part of the Electrical Power System of a Low Earth Orbit Satellite was considered. Data drift detection test was carried out using this sensor data using the developed novel statistical method and with Kolmogorov Smirnov test which is a probabilistic method. Both results are analysed and compared. Thereafter novel statical method was used to check its efficacy using a synthetic data set with induced drift.
New palaeocurrent analysis approach from two‐dimensional trough cross‐strata using photographs and anisotropy of magnetic susceptibility
Authors: Maars Jasper , van Dijk Gijs , Dekkers Mark J. , Hernández‐Molina F. Javier , Andreetto Federico , Rodríguez‐Tovar Francisco J. , Krijgsman Wout 
Published: March 2024

AbstractPalaeocurrent analysis is vital for basin analysis and helps in the interpretation of depositional environments (along‐slope or downslope). For that, it is crucial to have multiple measuring methods at hand to apply palaeocurrent analysis with a wide range of different datasets (outcrops, cores and photographs). Here, two relatively underexploited palaeocurrent measurement techniques are assessed when applied to trough cross‐stratification observed in the Arenazzolo Formation at Eraclea Minoa (Sicily). The first technique is a novel design of a qualitative approach to infer palaeocurrent directions from photographs of two‐dimensional sedimentary structures. The second technique involves measurements of the anisotropy of magnetic susceptibility from drilled samples. A broad agreement, with overlapping uncertainty boundaries, is observed between results from both techniques. This agreement validates the use of trough cross‐strata to infer palaeocurrent directions. Moreover, the addition of photographs improves reproducibility and prevents a bias towards the best‐exposed troughs. The application of both techniques to outcrops and sedimentary cores provides new opportunities for palaeocurrent analysis in any type of sedimentary environment.
Deciphering adipose development: Function, differentiation and regulation
Authors: Guo Ge , Wang Wanli , Tu Mengjie , Zhao Binbin , Han Jiayang , Li Jiali , Pan Yanbing , Zhou Jie , Ma Wen , Liu Yi , Sun Tiantian , Han Xu , An Yang 
Published: March 2024

AbstractThe overdevelopment of adipose tissues, accompanied by excess lipid accumulation and energy storage, leads to adipose deposition and obesity. With the increasing incidence of obesity in recent years, obesity is becoming a major risk factor for human health, causing various relevant diseases (including hypertension, diabetes, osteoarthritis and cancers). Therefore, it is of significance to antagonize obesity to reduce the risk of obesity‐related diseases. Excess lipid accumulation in adipose tissues is mediated by adipocyte hypertrophy (expansion of pre‐existing adipocytes) or hyperplasia (increase of newly‐formed adipocytes). It is necessary to prevent excessive accumulation of adipose tissues by controlling adipose development. Adipogenesis is exquisitely regulated by many factors in vivo and in vitro, including hormones, cytokines, gender and dietary components. The present review has concluded a comprehensive understanding of adipose development including its origin, classification, distribution, function, differentiation and molecular mechanisms underlying adipogenesis, which may provide potential therapeutic strategies for harnessing obesity without impairing adipose tissue function.
Physician perceptions, attitudes, and strategies towards implementing guideline‐directed medical therapy in heart failure with reduced ejection fraction. A survey of the Heart Failure Association of the ESC and the ESC Council for Cardiology Practice
Authors: Savarese Gianluigi , Lindberg Felix , Christodorescu Ruxandra M. , Ferrini Marc , Kumler Thomas , Toutoutzas Konstantinos , Dattilo Giuseppe , Bayes‐Genis Antoni , Moura Brenda , Amir Offer , Petrie Mark C. , Seferovic Petar , Chioncel Ovidiu , Metra Marco , Coats Andrew J.S. , Rosano Giuseppe M.C. 
Published: March 2024

AimsRecent guidelines recommend four core drug classes (renin–angiotensin system inhibitor/angiotensin receptor–neprilysin inhibitor [RASi/ARNi], beta‐blocker, mineralocorticoid receptor antagonist [MRA], and sodium–glucose cotransporter 2 inhibitor [SGLT2i]) for the pharmacological management of heart failure (HF) with reduced ejection fraction (HFrEF). We assessed physicians' perceived (i) comfort with implementing the recent HFrEF guideline recommendations; (ii) status of guideline‐directed medical therapy (GDMT) implementation; (iii) use of different GDMT sequencing strategies; and (iv) barriers and strategies for achieving implementation.Methods and resultsA 26‐question survey was disseminated via bulletin, e‐mail and social channels directed to physicians with an interest in HF. Of 432 respondents representing 91 countries, 36% were female, 52% were aged <50 years, and 90% mainly practiced in cardiology (30% HF). Overall comfort with implementing quadruple therapy was high (87%). Only 12% estimated that >90% of patients with HFrEF without contraindications received quadruple therapy. The time required to initiate quadruple therapy was estimated at 1–2 weeks by 34% of respondents, 1 month by 36%, 3 months by 24%, and ≥6 months by 6%. The average respondent favoured traditional drug sequencing strategies (RASi/ARNi with/followed by beta‐blocker, and then MRA with/followed by SGLT2i) over simultaneous initiation or SGLT2i‐first sequences. The most frequently perceived clinical barriers to implementation were hypotension (70%), creatinine increase (47%), hyperkalaemia (45%) and patient adherence (42%).ConclusionsAlthough comfort with implementing all four core drug classes in patients with HFrEF was high among physicians, a majority estimated implementation of GDMT in HFrEF to be low. We identified several important perceived clinical and non‐clinical barriers that can be targeted to improve implementation.
Innovative utilization of cell membrane‐coated nanoparticles in precision cancer therapy
Authors: He Yiling , Zhang Shuquan , She Yaoguang , Liu Zhaoshan , Zhu Yalan , Cheng Qinzhen , Ji Xiaoyuan 
Published: March 2024

AbstractCell membrane‐coated nanoparticles (CMNPs) have recently emerged as a promising platform for cancer therapy. By encapsulating therapeutic agents within a cell membrane‐derived coating, these nanoparticles combine the advantages of synthetic nanoparticles and natural cell membranes. This review provides a comprehensive overview of the recent advancements in utilizing CMNPs as effective drug delivery vehicles for cancer therapy. The synthesis and fabrication methods of CMNPs are comprehensively discussed. Various techniques, such as extrusion, sonication, and self‐assembly, are employed to coat synthetic nanoparticles with cell membranes derived from different cell types. The cell membrane coating enables biocompatibility, reducing the risk of an immune response and enhancing the stability of the nanoparticles in the bloodstream. Moreover, functionalization strategies for CMNPs, primarily chemical modification, genetic engineering, and external stimuli, are highlighted. The presence of specific cell surface markers on the coated membrane allows targeted drug delivery to cancer cells and maximizes therapeutic efficacy. Preclinical studies utilizing CMNPs for cancer therapy demonstrated the successful delivery of various therapeutic agents, such as chemotherapeutic drugs, nucleic acids, and immunotherapeutic agents, using CMNPs. Furthermore, the article explores the future directions and challenges of this technology while offering insights into its clinical potential.
Reflection of plane waves in a rotating micropolar double porous thermoelastic medium with temperature dependent properties
Authors: Sheoran Sandeep Singh , Kalkal Kapil Kumar , Chaudhary Shilpa 
Published: March 2024

AbstractThe objective of this empirical investigation is to explore the behavior of different waves reflected in a homogenous isotropic double porous structured micropolar thermoelastic medium with rotation and temperature‐dependent characteristics. Three‐phase‐lag theory of thermoelasticity is adopted to acquire the governing equations of the model. Six coupled plane waves have been found to propagate across the medium at distinct velocities. Derivation for energy and amplitude ratios of reflected waves were carried out by employing appropriate boundary conditions. For different angles of incidence, the outcomes for energy partition were determined numerically and displayed graphically. It is found that amplitude ratios associated with various reflected waves are affected by angular velocity, temperature‐dependent properties, micropolar parameter, and double porosity. Also, it has been discovered that throughout the reflection phenomena there is no dissipation of energy. Furthermore, this study concludes with a summary of the findings and subsequent observations. The current investigation has yielded inferences regarding specific cases that are of particular interest.