bluuebunny/crossref_metadata_2025_split huggingface dataset:
Green synthesis, characterization, and application of iron and molybdenum nanoparticles and their composites for enhancing the growth of Solanum lycopersicum
Authors: Habib Maria , Fatima Hina , Anwar Tauseef , Qureshi Huma , Aisida Samson O. , Ahmad Ishaq , Ali Iftikhar , Al-Mohaimeed Amal M. , Elshikh Mohamed S. , Razak Sarah Abdul , Kamal Asif 
Published: February 2024

Abstract
Nanomaterials have become integral in various aspects of agricultural practices, including the development of nano-fertilizers for optimized crop nutrition. This study explores the application of green-synthesized iron (Fe) and molybdenum (Mo) nanoparticles, as well as their composites, using a guava leaf extract (GLE). The focus is on assessing their impact on nitrogen fixation and growth in tomato plants (Solanum lycopersicum). The nanoparticles were characterized through Fourier Transform Infrared Spectroscopy, Ultraviolet Diffused Reflectance Spectroscopy, Raman Spectroscopy, and X-ray diffraction analysis. The experiment involved two application methods (soil and direct plant spraying) with varying nanoparticle concentrations. Results indicate that the 1% composite nanoparticles applied to the soil and 3% Mo directly on plants yield the most favorable growth and nitrogen uptake in S. lycopersicum. Notably, the 1% composite treatment demonstrated significant enhancement in shoot length, number of branches, and shoot diameter at all three growth stages. Conversely, the 3% Mo treatment when applied directly to plants exhibited optimal results showing substantial shoot length, number of branches, and shoot diameter. Post-experimental soil nutrient analysis further revealed the nuanced effects of nanoparticle applications with 1% composite treatments enhancing nutrient availability compared to control and other concentrations. This research contributes to the evolving field of agri-nanotechnology emphasizing the importance of nanoparticle concentration and application method in influencing plant development and nutrient uptake, paving the way for sustainable agricultural practices.
Quantitative structure-electrochemistry relationship modeling of a series of anticancer agents using MLR and ANN approaches
Authors: Bouarra Nabil , Kherouf Soumaya , Nadji Nawel , Nouri Loubna , Boudjemaa Amel , Djerad Souad , Bachari Khaldoun 
Published: February 2024

Abstract
QSPR is a powerful tool for elucidating the correlation between chemical structure and property for both natural and synthesized compounds. In the present work, the half-wave reduction potential for a set of aziridinylquinones (Anticancer Agents [AA]) is modelled using a quantitative structure-electrochemistry relationship (QSER) based on multilinear regression (MLR) and artificial neural network (ANN). Molecular descriptors introduced in this work were computed using the Dragon software (V5). Before the model’s generation, using the Kennard and Stone algorithm, the data set of 84 aziridinylquinones was divided into training and prediction sets consisting of 70 % and 30 % of data points. Quantitative Structure Electrochemistry Relationship (QSER) models were developed using the Genetic Algorithm Multiple Linear Regressions (GA-MLR) and an Artificial Neural Network (ANN). The coefficient of determination (R
2) and Root Mean Squared Error of prediction (RMSE) were mentioned to demonstrate the QSER model’s prediction abilities. Calculated R
2 and RMSEval values for the MLR model were 0.858 and 0.054, respectively. The R
2 and RMSEval values for the ANN training set were calculated to be 0.914 and 0.050, respectively. Findings show that GA is a powerful tool for selecting variables in QSER analysis. Comparing the two employed regression methods showed that ANN is superior to MLR in predictive ability.
Lessons in clinical reasoning – pitfalls, myths, and pearls: a case of tarsal tunnel syndrome caused by an intraneural ganglion cyst
Authors: Phadke Sanjay Vishnu , Dalal Chirag , Seetharaman Rajmohan , Parsons Andrew S. 
Published: February 2024

Abstract

Objectives
Intraneural ganglionic cysts are non-neoplastic cysts that can cause signs and symptoms of peripheral neuropathy. However, the scarcity of such cases can lead to cognitive biases. Early surgical exploration of space occupying lesions plays an important role in identification and improving the outcomes for intraneural ganglionic cysts.

Case presentation
This patient presented with loss of sensation on the right sole with tingling numbness for six months. A diagnosis of tarsal tunnel syndrome was made. Nerve conduction study revealed that the mixed nerve action potential (NAP) was absent in the right medial and lateral plantar nerves. The magnetic resonance imaging (MRI) found a cystic lesion measuring 1.4×1.8×3.8 cm as the presumed cause of the neuropathy. Surgical exploration revealed a ganglionic cyst traversing towards the flexor retinaculum with baby cysts. The latter finding came as a surprise to the treating surgeon and was confirmed to be an intraneural ganglionic cyst based on the histopathology report.

Conclusions
Through integrated commentary by a case discussant and reflection by an orthopedician, this case highlights the significance of the availability heuristic, confirmation bias, and anchoring bias in a case of rare disease. Despite diagnostic delays, a medically knowledgeable patient’s involvement in their own care lead to a more positive outcome. A fish-bone diagram is provided to visually demonstrate the major factors that contributed to the diagnostic delay. Finally, this case provides clinical teaching points in addition to a pitfall, myth, and pearl related to availability heuristic and the sunk cost fallacy.
Correlation of fetal heart rate dynamics to inflammatory markers and brain-derived neurotrophic factor during pregnancy
Authors: Mercado Luis , Rose Shannon , Escalona-Vargas Diana , Siegel Eric R. , Whittington Julie R. , Preissl Hubert , Helmich Melissa , Eswaran Hari 
Published: February 2024

Abstract

Objectives
This study aims to show the relation between biomarkers in maternal and cord-blood samples and fetal heart rate variability (fHRV) metrics through a non-invasive fetal magnetocardiography (fMCG) technique.

Methods
Twenty-three women were enrolled for collection of maternal serum and fMCG tracings immediately prior to their scheduled cesarean delivery. The umbilical cord blood was collected for measurement of biomarker levels. The fMCG metrics were then correlated to the biomarker levels from the maternal serum and cord blood.

Results
Brain-derived neurotrophic factor (BDNF) had a moderate correlation with fetal parasympathetic activity (0.416) and fetal sympathovagal ratios (−0.309; −0.356). Interleukin (IL)-6 also had moderate-sized correlations but with an inverse relationship as compared to BDNF. These correlations were primarily in cord-blood samples and not in the maternal blood.

Conclusions
In this small sample-sized exploratory study, we observed a moderate correlation between fHRV and cord-blood BDNF and IL-6 immediately preceding scheduled cesarean delivery at term. These findings need to be validated in a larger population.
Preliminary assessment of the Healthy Early Life Moments (HELMS) webinars in empowering Developmental Origins of Health and Disease (DOHaD) concept among healthcare professionals – a pragmatic serial cross-sectional study
Authors: Ku Chee Wai , Ng Roderica R.G. , Chang Ting Yu , Lim Celeste H.F. , Zheng Ruther Teo , Ma Weini , Chua Mei Chien , Chan Jerry K.Y. , Yap Fabian K.P. , Loy See Ling 
Published: February 2024

Abstract

Objectives
The Developmental Origins of Health and Disease (DOHaD) concept has gained prominence in maternal and child health (MCH), emphasizing how early-life factors impact later-life non-communicable diseases. However, a knowledge–practice gap exists in applying DOHaD principles among healthcare professionals. Healthy Early Life Moments in Singapore (HELMS) introduced webinars to bridge this gap and empower healthcare professionals. We aimed to conduct a preliminary assessment to gain early insights into the outreach and effectiveness of the educational initiative offered with the HELMS webinars.

Methods
We employed a pragmatic serial cross-sectional study approach and targeted healthcare professionals involved in MCH care. We also collected and analyzed data on webinar registration and attendance, participants’ profession and organizational affiliations, and post-webinar survey responses.

Results
The median webinar attendance rate was 59.6 % (25th–75th percentile: 58.4–60.8 %). Nurses represented 68.6 % of attendees (n=2,589 out of 3,774). Post-webinar surveys revealed over 75 % of the participants providing positive responses to 14 out of 15 survey questions concerning content, delivery, applicability to work, and organization.

Conclusions
Assessment of the HELMS webinars provided insight into the outreach and early effectiveness in enhancing healthcare professionals’ knowledge and confidence in delivering DOHaD education. Bridging the knowledge–practice gap remains a crucial goal.
Metaphor forces argument overtness
Authors: Reinöhl Uta , Ellison T. Mark 
Published: February 2024

Abstract
This paper uncovers how metaphor forces argument overtness – across languages and parts of speech. It addresses the relationship between semantically unsaturated terms, functors, and the argument terms that complete them. When the component terms’ default senses clash semantically, a metaphor arises. In such cases, the argument must be overt, in contrast to literal uses. It is possible to say Everyone was waiting at the hotel. Finally, Kim arrived. By contrast, people do not use arrived metaphorically without a goal argument: Everything had been pointing to that conclusion all along. *Finally, Kim arrived. What they say is Finally, Kim arrived at it. We illustrate the phenomenon with powerful and diverse evidence: three corpus studies (Indo-Aryan languages, British English, Vera’a) and a sentence-completion experiment with around 250 native speakers of English. Both the corpus studies and the experiment show no or almost no exceptions to metaphor-driven argument overtness. The strength of the effect contrasts with a complete lack of speaker awareness. We propose that metaphor-driven argument overtness – as well as the lack of speaker consciousness – is a universal phenomenon that can be accounted for in terms of human language processing.
Facilitating or compromising inclusion? Language policies at Swedish higher education institutions as workplaces
Authors: Jeong Hyeseung , Lindemann Stephanie 
Published: February 2024

Abstract
Research has suggested that Swedish higher education institutions’ (HEIs’) language policies may exclude some academic staff from work-related activities due to (dual) monolingual ideologies requiring one language at a time. This study, based on the analysis of twenty-one language policy texts, investigates HEIs’ policies using a lens of inclusion at workplaces with linguistic diversity, drawing on concepts from diversity management and language policy for democracy of inclusion. All documents examined began with statements of HEIs’ values relevant to the policies. Inclusion was seldom explicitly emphasized, although policies suggested ways to facilitate it. We argue that some of the approaches – namely, taking a top-down monolinguistic approach to language choice, requiring staff to be highly proficient in both Swedish and English, and offering unspecified language support – reinforce language-based in-groups and out-groups, likely compromising rather than facilitating inclusion. Another approach, emphasizing individuals’ rights to choose what language they use, facilitates inclusion only if support is provided for everyone’s understanding. Providing immediate language support and encouraging bottom-up, flexible language choice were less common approaches but seem particularly likely to facilitate inclusion. Our analysis suggests that policies prioritizing successful communication, not specific languages, facilitate inclusion and help employees develop job-related language and intercultural communicative competence.
Crystal structure of methyl 3-methoxy-4-(2-methoxy-2-oxoethoxy)benzoate, C12H14O6
Authors: Yan-Ling Zheng , Miao-Miao Li 
Published: February 2024

Abstract
C12H14O6, triclinic, P

1
‾

$\overline{1}$

(no. 2), a = 5.3644(9) Å, b = 11.1880(18) Å, c = 11.4159(18) Å, α = 66.378(2)°, β = 79.970(2)°, γ = 78.138(2)°, V = 611.11(17) Å3, Z = 2, R
gt(F) = 0.0430, wR
ref(F
2) = 0.1260, T = 296(2) K.
Crystal structure of 2-(naphthalen-1-yl)ethyl 2-(6-methoxynaphthalen-2-yl)propanoate, C26H24O3
Authors: Xue De-dong , Hou Yu , Wan Li-jian 
Published: February 2024

Abstract
C26H24O3, monoclinic, P21 (no. 4), a = 11.4253(9) Å, b = 6.0417(5) Å, c = 14.9373(12) Å, β = 92.718(3)°, V = 1029.94(14) Å3, Z = 2, R
gt(F) = 0.0354, wR
ref(F
2) = 0.0875, T = 100(2) K.
Association between exposure to per- and polyfluoroalkyl substances and levels of lipid profile based on human studies
Authors: Song Xinru , Ye Tingtao , Jing Dongmei , Wei Kai , Ge Yue , Bei Xinyue , Qi Yuqian , Wang Huanqiang , Li Jun , Zhang Yan 
Published: February 2024

Abstract
Epidemiological evidence suggests that exposure to per- and polyfluoroalkyl substances (PFAS) is associated with lipid profile levels, but with inconsistent conclusions from different studies. The aim of this study was to conduct a meta-analysis of the relationship between PFAS exposure and lipid profile levels based on population-based epidemiological studies. Embase, PubMed, Ovid database, The Cochrane Library and Web of Science database were used to search appropriate studies (before September 6, 2022) on the correlation between PFAS exposure and lipid profile levels. β value, odd ratio (OR) and 95 % confidence intervals (CIs) were extracted from studies. In this study, we found that higher low-density lipoprotein (LDL) levels were associated with exposure to perfluoroundecanoic acid (PFUnDA) (β value=0.13, 95 % CIs: 0.02, 0.24) and perfluorooctane sulfonic acid (PFOS) (β value=0.13, 95 % CIs: 0.04, 0.21). PFOA, PFOS and PFNA exposure were significantly related to the higher levels of total cholesterol (TC) with the pooled effect estimates of 0.08 (95 % CI: 0.02, 0.14), 0.13 (95 % CI: 0.05, 0.21) and 0.14 (95 % CI: 0.08, 0.20) respectively. In sum, our results identified that PFOA, PFOS, PFNA and PFUnDA were the most important risk factors for abnormal levels of lipid profile, indicating that we should prevent cerebrovascular disease by reducing and controlling PFAS exposure.
Silibinin suppresses glioblastoma cell growth, invasion, stemness, and glutamine metabolism by YY1/SLC1A5 pathway
Authors: Liu Ming , Liu Xipeng , Qiao Jianxin , Cao Bing 
Published: February 2024

Abstract

Background
Silibinin has been found to inhibit glioblastoma (GBM) progression. However, the underlying molecular mechanism by which Silibinin regulates GBM process remains unclear.

Methods
GBM cell proliferation, apoptosis, invasion, and stemness are assessed by cell counting kit-8 assay, EdU assay, flow cytometry, transwell assay, and sphere formation assay. Western blot is used to measure the protein expression levels of apoptosis-related markers, solute carrier family 1 member 5 (SLC1A5), and Yin Yang-1 (YY1). Glutamine consumption, glutamate production, and α-ketoglutarate production are detected to evaluate glutamine metabolism in cells. Also, SLC1A5 and YY1 mRNA levels are examined using quantitative real-time PCR. Chromatin immunoprecipitation assay and dual-luciferase reporter assay are used to detect the interaction between YY1 and SLC1A5. Mice xenograft models are constructed to explore Silibinin roles in vivo.

Results
Silibinin inhibits GBM cell proliferation, invasion, stemness, and glutamine metabolism, while promotes apoptosis. SLC1A5 is upregulated in GBM and its expression is decreased by Silibinin. SLC1A5 overexpression abolishes the anti-tumor effect of Silibinin in GBM cells. Transcription factor YY1 binds to SLC1A5 promoter region to induce SLC1A5 expression, and the inhibition effect of YY1 knockdown on GBM cell growth, invasion, stemness, and glutamine metabolism can be reversed by SLC1A5 overexpression. In addition, Silibinin reduces GBM tumor growth by regulating YY1/SLC1A5 pathway.

Conclusion
Silibinin plays an anti-tumor role in GBM process, which may be achieved via inhibiting YY1/SLC1A5 pathway.
Purification of water using TiO2/g-C3N5 nanocomposite: a visible light assisted photocatalytic activity
Authors: Chandrasekar Jayashree , Venkatesan Manikandan , Lin Ja-Hon , Kuo Chi-Ching 
Published: February 2024

Abstract
Tetracycline hydrochloride (TCN), widely recognized for its broad-spectrum efficacy and cost-effectiveness as an antibiotic, has raised significant environmental and health concerns due to its contamination in water bodies. This study introduces an innovative approach to address this issue by employing a titanium dioxide/graphitic carbon nitride (TiO2/g-C3N5) nanocomposite through photocatalysis. The synthesis of this composite involved a hydrothermal method, and a comprehensive characterization was conducted using XRD, FT-IR, and SEM techniques. The formed heterojunction between TiO2 and g-C3N5 exhibited remarkable photocatalytic degradation capabilities, achieving a removal rate of over 85 % within a short period of 135 min. This signifies the composite’s efficiency in breaking down TCN in aqueous environments. Beyond its high effectiveness, the TiO2/g-C3N5 nanocomposite presents itself as an environmentally friendly and sustainable solution for addressing the critical issues associated with antibiotic contamination in water. This study underscores the potential of photocatalysis using TiO2/g-C3N5 as a promising technology for mitigating the adverse effects of TCN on both ecosystems and human health.
ВИДИ УПРАВЛІНСЬКОГО КОНТРОЛЮ У ЗАКЛАДАХ ВИЩОЇ ОСВІТИ
Authors: СТОДІЛКО ДАНИЛО-МИХАЙЛО 
Published: February 2024

У статті розглянуто види управлінського контролю, розкрито сутність видів управлінського контролю у закладі вищої освіти; доведено процес відстеження ходу виконання прийнятих управлінських рішень і оцінки досягнутих результатів у ході. Встановлено, що основною причиною необхідності контролю, є невизначеність, що представляє невід’ємний елемент майбутнього і притаманна будь-якому стратегічному рішенню та його реалізації, оскільки прийняття рішення здійснюється на підставі бачення ситуації керівником тієї чи іншої моделі ситуації, що використовується в прийнятті управлінського рішення, яка завжди є частковою.
Обґрунтовано, що надійна система управлінського контролю ґрунтується на ефективному зворотному зв’язку, який особливо проявляється в адекватній реакції на зміни, що відбуваються у зовнішньому середовищі та у процесі реалізації прийнятих управлінських рішень.
З’ясовано, що добре налагоджена система контролю своєчасно виявить проблеми, що виникають, слабкі сторони і загрози, а також ефективна система контролю дозволяє виявити позитивні та сильні сторони, які виникли у здійсненні її діяльності.
Контроль в управлінні ЗВО як одна з основних функцій управління, що забезпечує механізм зворотного зв’язку, дозволяє своєчасно реагувати на небажані відхилення від намічених орієнтирів з метою досягнення поставлених цілей.
Inappropriate Use of Peripherally Inserted Central Catheters in Pediatrics: A Multisite Study
Authors: Burek Alina G. , Davis Mary Beth , Pechous Brittany , Shaughnessy Erin E. , Meier Katie A. , Mooney Sarah , Woodruff Dana , Bruner Meaghan , Piper Laura , Liegl Melodee , Pan Amy , Brousseau David C. , Ullman Amanda J. 
Published: February 2024

OBJECTIVES
This study aimed to describe how the current practice of peripherally inserted central catheter (PICC) use in hospitalized children aligns with the Michigan Appropriateness Guide for Intravenous Catheters (miniMAGIC) in Children recommendations, explore variation across sites, and describe the population of children who do not receive appropriate PICCs.

METHODS
A retrospective study was conducted at 4 children’s hospitals in the United States. Children with PICCs placed January 2019 to December 2021 were included. Patients in the NICU were excluded. PICCs were categorized using the miniMAGIC in Children classification as inappropriate, uncertain appropriateness and appropriate.

RESULTS
Of the 6051 PICCs identified, 9% (n = 550) were categorized as inappropriate, 9% (n = 550) as uncertain appropriateness, and 82% (n = 4951) as appropriate. The number of PICCs trended down over time, but up to 20% of PICCs each year were not appropriate, with significant variation between sites. Within inappropriate or uncertain appropriateness PICCs (n = 1100 PICC in 1079 children), median (interquartile range) patient age was 4 (0–11) years, 54% were male, and the main reason for PICC placement was prolonged antibiotic course (56%, n = 611). The most common admitting services requesting the inappropriate/uncertain appropriateness PICCs were critical care 24%, general pediatrics 22%, and pulmonary 20%. Complications resulting in PICC removal were identified in 6% (n = 70) of inappropriate/uncertain PICCs. The most common complications were dislodgement (3%) and occlusion (2%), with infection and thrombosis rates of 1% (n = 10 and n = 13, respectively).

CONCLUSIONS
Although the majority of PICCs met appropriateness criteria, a substantial proportion of PICCs were deemed inappropriate or of uncertain appropriateness, illustrating an opportunity for quality improvement.
The Trinitarian Iconography
Authors: Witko Andrzej 
Published: February 2024

The Trinitarian Order, Ordo Sanctissimae Trinitatis de Redemptione Captivorum, was founded by St. John de Matha (d. 1213) with the participation of St. Felix de Valois (d. 1212). The first abode was located in Cerfroid, in the diocese of Meaux in France. Pope Innocent III approved the Order in his bull Operante divine dispositionis of December 17, 1198 and ratified the Rule written by St. John de Matha who described the aim of the Trinitarian mission as ransoming captives from pagans as well as providing hospital care to the sick and the poor.
Water vapour permeability of inorganic construction materials
Authors: Hall Christopher , Lo Gloria J. , Hamilton Andrea 
Published: February 2024

AbstractWater vapour permeability (WVP) data on brick, stone, plaster and cement-based materials from some seventy publications are reviewed and assessed. Almost all sources use standard cup-test methods or close variants. Comparisons of WVP values from different sources on similar materials confirm that reproducibility between different laboratories is poor. Some deficiencies of cup-test methods are discussed, including uncertainties arising from the use of saturated-salt humidistats and desiccants. There is evidence that the water vapour resistance factor decreases as volume-fraction porosity increases, and data support a simple porosity–tortuosity relation. Data also show that the resistance factor decreases with increasing mean relative humidity across the test specimen, with the wet-cup value consistently lower than the dry-cup values for a given material. The contribution of liquid film flow to mass transfer is discussed. It is shown how film thickness and film-flow permeability may be estimated from the water-vapour sorption isotherm; and a related regression equation is developed It is concluded that available data are inadequate to establish the fundamental physics of WVP; vapour-only permeability data for engineering purposes should be obtained in dry-cup tests at low humidity; and research studies should aim to integrate the WVP into the framework of unsaturated flow theory.