bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phase I study of concurrent carboplatin and radiotherapy in previously untreated patients with stage III and IV head and neck cancer
Authors: Osoba David , Flores Albino D. , Hay John H. , Wong Frances , Maher Maureen 
Published: February 2007

AbstractThis study evaluated the toxicity resulting from combined therapy using carboplatin and radiotherapy in 22 patients with locally advanced (stage III and IV) head and neck cancer. Carboplatin was given after radiotherapy during the first 5 consecutive days of a 16‐fraction course of radiotherapy delivered in a total of 22 days. To find the acceptable toxic dose of carboplatin, the patients were treated in groups of 3 patients each. The first group received 50 mg/m2carboplatin and the dose was increased by 10 mg/m2in each subsequent group. Unacceptable toxicity (severe mucositis, nausea and vomiting, and/or myelo‐suppression) was encountered at a carboplatin dose of 80 mg/m2. A further 10 patients were then treated at a dose of 70 mg/m2. At this dose toxicity was acceptable. Although the group of 22 patients is too small for response and survival data to be meaningful, 10 complete responses were seen and median survival is in excess of 67 weeks.
Schwannoma of the submandibular gland
Authors: Diaz Dennis D. , Kennedy Kevin S. , Parker Gregg S. , White Valerie J. 
Published: February 2007

AbstractNeurilemmomas (schwannomas) are solitary neurogenic tumors that arise from cells of the neural sheath. They are slow growing and represent a proliferation of Schwann cells. Extracranial neurogenic tumors of the head and neck are uncommon, with benign tumors occurring with greater frequency than malignant tumors. These tumors often mimic primary or metastatic disease in the head and neck. Schwannoma of the salivary gland is a particularly rare form of an extracranial neurogenic tumor, with most presenting in the parotid gland originating from a peripheral branch of the facial nerve. An unusual case of neurilemmoma of the submandibular gland is presented, and the literature concerning this subject is reviewed. We believe this tumor originated in an autonomic nerve of the submandibular gland. The mass was discrete and well demonstrated on CT scan. Total excision of the gland resulted in complete resolution of symptoms with no cranial nerve deficits.
Time to recurrence of squamous cell carcinoma of the head and neck
Authors: Stell Philip M. 
Published: February 2007

AbstractA personal series of 3,215 patients with proven squamous cell carcinoma of the mucosal surfaces of the upper aerodigestive tract is presented. Of these patients, 515 suffered a recurrence of their primary tumor after a course of radiotherapy. The time from the end of radiotherapy to diagnosis of a primary recurrence was not related to any known host factors, nor to tumor factors except site. However, it was the most significant predictor of survival, both from initial presentation and from the date of recurrence. The time to recurrence did not relate to the size of the tumor at recurrence, suggesting that large recurrences are multicentric. The time to recurrence also predicted response and survival of 67 patients with end‐stage disease treated by chemotherapy. The response and survival were better in tumors with a time to recurrencelongerthan the median; the increased survival was not significant, but the increased response was.
Induction intra‐arterial cisplatin and bleomycin in head and neck cancer
Authors: Frustaci Sergio , Barzan Luigi , Caruso Giuseppe , Ghirardo Riccardo , Foladore Silva , Carbone Antonino , Comoretto Yroberto , Serafini Italo , Monfardini Silvio 
Published: February 2007

AbstractFifty‐two consecutive patients, affected by large T2 (>3 cm), T3, T4, N0, or N1 previously untreated squamous cell carcinoma of the head and neck, entered this phase I ‐ II study. Treatment consisted of a continuous 8‐day infusion on the following daily schedule: cisplatin 25 mg and bleomycin 15 mg administered for 4 and 20 hours, respectively. Technical‐related toxicities were 1 case each of coagulation and displacement of the catheter and 1 case of reversible monoparesis of the contralateral arm. Drug‐related relevant toxicities accounted for 4 cases of grade 3 or 4 leukopenia and 2 cases of peripheral palsy of the 7th and 12th cranial nerve, respectively. Forty‐five of 50 evaluable patients obtained an objective response. In particular, 13 patients obtained a complete response, 22 a partial response ⩾75%, and 10 a partial response ⩾50%. Furthermore, 5 of 31 patients showed a complete pathologic disappearance of the tumor, whereas in 12 of 31 only a microscopic residue was found.
Prognostic value of paranasopharyngeal extension of nasopharyngeal carcinoma on local control and short‐term survival
Authors: Sham Jonathan S. T. , Choy D. 
Published: February 2007

AbstractThe local tumor control of 262 patients with nasopharyngeal carcinoma (NPC) at median follow‐up of 27 months was studied with reference to the paranasopharyngeal and other aspects of extranasopharyngeal extension of tumor, as well as to other possible prognostic factors. Only cranial nerve palsy, oropharyngeal involvement, and paranasopharyngeal extension of tumor were found to be significant in a multivariate analysis using Cox model for factors influencing local tumor control. Other factors and other parameters of extranasopharyngeal extension of tumor, namely, erosion of the base of skull, intracranial extension, and involvement of nasal fossa, were found not to be significant. The degree of paranasopharyngeal extension in each side was correlated with scales measuring extranasopharyngeal extension of tumor in other directions (p= 0.001). Although the T stage and the paranasopharyngeal extension were individually found to be well correlated with local tumor control, the prognostic value of paranasopharyngeal extension remained significant among subgroups of patients with T3 and T4 disease (p= 0.1044 and 0.0010, respectively).
Preoperative evaluation of the mandible in patients with carcinoma of the floor of mouth
Authors: Shaha Ashok R. 
Published: February 2007

AbstractPreoperative evaluation of the mandible for invasion by tumor has always been a difficult problem. Various methods have been used, including clinical evaluation, panoramic x‐rays, dental films, routine mandible films, bone scans, computed tomographic (CT) scans, and magnetic resonance imaging (MRI) scans. The diagnostic accuracy of these methods has not been totally satisfactory from the clinical standpoint. We compared the diagnostic effectiveness of clinical evaluation, panorex films, and CT scans in 60 patients with carcinoma of the floor of mouth. The relative value of these tests was studied in relation to marginal or segmental mandibulectomy. Our data showed that CT scanning was not very helpful, mainly because of the presence of irregular dental sockets and artifacts. Clinical evaluation was the most accurate, both to determine bone invasion and to decide the type of mandibular resection necessary in association with the primary tumor.Panoramic films were helpful in evaluating the gross extent of mandibular invasion. However, they were not of any help in determining minimal bony invasion or cortical invasion. Even though CT scanning has made a tremendous impact in other areas of head and neck surgery, it is not of much help in making the critical decisions in the type of mandible resection, marginal or segmental, in patients with carcinoma of the floor of mouth. Our experience demonstrates that clinical evaluation is superior in preoperative evaluation of the mandible, and especially in deciding the type of mandible resection.
Value of needle biopsy in directing management of parotid lesions in HIV‐positive patients
Authors: Casiano Roy R. , Cooper Jonathan D. , Gould Edwin , Ruiz Phillip , Uttamchandani Raj 
Published: February 2007

AbstractFourteen human immunodeficiency virus (HIV)‐positive patients with parotid enlargement were reviewed retrospectively in order to elucidate the natural history of this clinical entity. The efficacy of fine‐needle aspiration (FNA) in predicting benign nonsurgical disease was evaluated. The most common findings on FNA were proteinaceous fluid and/or epithelial cells consistent with cyst contents in 71% of the patients, followed by reactive lymphadenitis (50%), and chronic or granulomatous inflammation (21%). No evidence of malignancy was seen in any patient. These results correlated well with the histopathologic diagnosis in all operated patients. Surgery did not affect the ultimate clinical outcome. This study suggests that HIV‐positive patients with isolated asymptomatic parotid swelling in the absence of other clinical features suggestive of malignancy can be followed conservatively with FNA, avoiding the risks of surgery.
Miniplate fixation of zygomatic fractures
Authors: Berman Peter D. , Jacobs Joseph B. 
Published: February 2007

AbstractThe availability and application of miniplate systems for the repair of displaced zygomatic fractures may effect commonly accepted guidelines for fixation of these injuries. A retrospective review of 20 patients at New York University‐Bellevue Medical Center was conducted to further delineate issues concerning surgical repair and fixation. Our experience with one‐ and two‐point fixation is evaluated and guidelines are presented.
Carcinoma of the skin metastatic to parotid area lymph nodes
Authors: Taylor Bernard W. , Brant Timothy A. , Mendenhall Nancy Price , Mendenhall William M. , Cassisi Nicholas J. , Stringer Scott P. , Million Rodney R. 
Published: February 2007

AbstractThis is a retrospective analysis of 60 patients with previously untreated metatypical basal cell (3 patients) or squamous cell (57 patients) carcinoma of the skin, metastatic to the parotid area. All patients had a minimum 2‐year follow‐up, and 43% had a minimum 5‐year follow‐up. Treatment was surgery alone (8 patients), irradiation alone (16 patients), or planned combined surgery and irradiation (36 patients). The ultimate rates of control of disease in the parotid area were surgery alone, 5 of 8 (63%); irradiation alone, 6 of 13 (46%); planned combined surgery and irradiation, 32 of 36 (89%). In the combined‐treated group, all 4 recurrences were in patients who had positive surgical margins and gross involvement of the facial nerve. In patients with negative surgical margins, without involvement of the facial nerve, who had combined treatment, the control rate was 100%. Of the surgery‐alone group, only 1 patient ultimately had the disease controlled and retained a functioning facial nerve.
Neurilemmomas of the cervical vagus nerve
Authors: Park Cheong Soo , Suh Kwang Wook , Kim Choon Kyu 
Published: February 2007

AbstractFour patients were seen with neurilemmoma which arose in the cervical vagus nerve. Three tumors arose in the upper third of the lateral neck, and the remaining one in the lower third. Lateral neck mass was a prominent symptom in 3 patients, and parapharyngeal mass in the remaining one. The parapharyngeal mass bulged into the oropharynx in the tonsillar and retrotonsillar region and caused mild swallowig difficulty. Complete surgical extirpation by means of intracapsular enucleation was possible in all 4 patients. All patients remained free of disease for periods ranging from 15 to 75 months following surgery. It would appear that an intracapsular enucleation may be advisable for clearance of this kind of tumor.
Giant teflon granuloma of the larynx
Authors: Benjamin Bruce , Robb Peter , Clifford Anthony , Eckstein Robert 
Published: February 2007

AbstractEndolaryngeal injection of Teflon paste to augment and medialize the paralyzed hemilarynx aims to improve dysphonia and relieve aspiration. After an initial short‐lived inflammatory reaction in the laryngeal tissues, a foreign body granuloma forms around the Teflon. In most cases the results are good but it may occasionally be necessary to consider removal of the granuloma if too large a volume has been injected, if it is inappropriately placed, or if the paralyzed vocal cord subsequently recovers. Surgical removal is difficult and the results are unpredictable. This case illustrates, for the first time, that evaluation using both a high‐resolution computed tomographic (CT) scan and endos‐copy with telescopes permits satisfactory assessment before removal of Teflon.
Prognostic factors in head and neck cancer: Histologic grading, dna ploidy, and nodal status
Authors: Zätterström Ulf K. , Wennerberg Johan , Ewers Sven‐Börje , Willen Roger , Attewell Robyn 
Published: February 2007

AbstractHistopathologic malignancy score and DNA ploidy were investigated as prognostic factors for 72 cases of squamous cell carcinoma of the head and neck (HNSCC). The malignancy grading was based upon four different morphologic characteristics for the tumor cell population and four characteristics for the tumorhost relationship. DNA ploidy was determined through flow cytometry on fresh‐frozen tumor samples. The median malignancy score was 20, with 71% of the tumors scoring < 20 being diploid and 68% of the tumors scoring ⩾ 20 being nondiploid (p = 0.003). Univariate analysis revealed that tumors scoring < 20 and diploid tumors had a significantly higher proportion of complete response and better survival as compared to tumors scoring ⩾ 20 and nondiploid tumors, respectively. There was a tendency toward better survival among patients without regional metastasis (NO) as compared with patients with regional spread (N+), whereas the other single factors, patient age, clinical stage, histologic grade, and tumor size did not correlate with prognosis. In N+ patients both malignancy score and DNA ploidy were predictive for survival, whereas in NO patients only malignancy score was related to prognosis. A multivariate analysis showed that the combination of malignancy score and nodal status were the strongest predictors for survival. DNA ploidy did not contribute further information in this test, due to its close relation with the histopathologic malignancy score.
Neuroendocrine tumors of the larynx
Authors: Moisa Idel I. 
Published: February 2007

AbstractA review of the international literature has revealed 68 paragangliomas, 42 large cell, and 74 small cell tumors of the larynx. Paragangliomas are usually benign, although malignant cases have been reported. Large cell tumors are malignancies associated with a high incidence of early cervical metastasis. Small cell tumors are aggressive cancers characterized by early, diffuse metastatic disease. All three neoplasms demonstrate a propensity for the supraglottic larynx. While surgery remains the treatment of choice for paragangliomas and large cell cancers, small cell cancers are best treated by radiotherapy and chemotherapy. The determinate 5‐year survival for patients with paragangliomas, large cell, and small cell cancers is 60%, 34%, and 14%, respectively. While representing distinct clinical entities, these neoplasms demonstrate similar ultrastructural and histochemical features and should be classified as neuroendocrine tumors of the larynx (NETL). A comprehensive analysis of these laryngeal tumors is presented herein. Their clinical behavior and management options are reviewed and a scheme for their nomenclature and classification is proposed.
Anaplastic large cell lymphoma
Authors: Foss Robert D. , Laskin William B. , Lombardi Donald P. , Morton Anthony L. , Snyder James 
Published: February 2007

AbstractAnaplastic large cell lymphoma (ALCL) or Ki‐1 lymphoma is a recently described and distinctive non‐Hodgkin's lymphoma. Cervicofacial adenopathy caused by ALCL may mimic involvement by metastatic carcinoma or other malignancies common to the head and neck. A case in which ALCL was originally interpreted as metastatic nasopharyngeal carcinoma is presented. The clinicopathologic features of this uncommon entity are discussed.
Gene amplification and overexpression of epidermal growth factor receptor in squamous cell carcinoma of the head and neck
Authors: Rikimaru Koichi , Tadokoro Keiko , Yamamoto Tadashi , Enomoto Shoji , Tsuchida Nobuo 
Published: February 2007

AbstractThe degree of gene amplification for epidermal growth factor receptor (EGFR) and its expression levels were examined in 4 cases of tumor lesions and their cell lines of human squamous cell carcinoma (SCC) of the oral cavity. The amplification was detected in 1 case (ZA), but not significantly in 3 other cases (HOC605, HOC815, and HOC927) in which the amplification did not occur during the cell line establishment. In those 3 cases, levels of EGFR synthesis and human EGF (hEGF) binding capacity were varied: HOC605 and HOC815 had slightly increased levels of hEGF binding capacity and EGFR synthesis, respectively. While HOC927 had the lowest levels of both, the hEGF binding capacity was elevated in the tumor lesion when compared with the normal counterpart of the same patient. These results suggest that the increased capacity for EGF binding plays a more important role than does gene amplification on the tumorigenesis of SCC of the head and neck.
Medical liaisons for continuity of head and neck cancer care
Authors: Benninger Michael S. 
Published: February 2007

AbstractThe role of assistance in coordinating treatment and follow‐up on the effectiveness and reliability of long‐term care of head and neck cancer patients was evaluated. A comparison between the Department of Radiation Oncology, where a liaison team assists cancer patients, and the Department of Otolaryngology, where there were no such personnel, was made. Of 124 consecutive patients with head and neck squamous cell carcinoma, 31 were treated with surgery alone and 93 had radiation therapy alone or in combination with surgery. Patients were nearly equally divided among stages, although a higher percentage receiving surgery were stage I and those receiving radiation were stage IV. Nineteen radiation patients and 1 surgery patients have died; this is consistent with the differences in stage distribution. Thirteen of 31 surgery patients had unreliable follow‐up, with 7 lost to follow‐up. Only 8 of 93 radiation patients were unreliable, with 4 lost. The difference is statistically significant. The importance of nursing/social work liaisons in coordinating treatment and follow‐up of head and neck cancer patients is discussed.
Botulinum a toxin for spasmodic torticollis: Multiple vs single injection points per muscle
Authors: Borodic Gary E. , Pearce L. Bruce , Smith Karen , Joseph Michael 
Published: February 2007

AbstractEighty‐six injections in 49 patients with adult onset spasmodic torticollis were evaluated for efficacy with respect to single point per muscle versus multiple point per muscle injection techniques. Parameters of the syndrome assessed were pain, posture deformity, range of cervical motion, disfigurement, cervical muscle hypertrophy, activity limitation, and degree of involuntary movement. The multiple point per muscle injection strategy appeared superior to the single injection per muscle technique with respect to pain (p < 0.002, chi‐square), posture deformity (p < 0.001), range of motion (p < 0.001), and improvement in activity endurance (p < 0.001). No significant differences were noted with respect to cervical muscle hypertrophy or degree of involuntary movements, although the injections were considered beneficial in both groups to these syndrome components.
Bilateral tonsillar metastasis of gastric adenocarcinoma
Authors: Gallo Andrea , Pescarmona Edoardo , Crupi Jacqueline , Corsetti Gian Luca , De Vincentiis Marco 
Published: February 2007

AbstractThe occurrence of metastatic tumors in the tonsils, although rare, must be considered in the differential diagnosis of tonsillar lesions. In particular, the review of the literature reports only 7 cases of tonsillar metastasis of gastric carcinoma. The authors describe a case of adenocarcinoma involving bilaterally the palatine tonsils and the lingual tonsil, in a patient previously operated due to gastric adenocarcinoma. The clinical appearance of the lesion could be also consistent with lymphoproliferative or infectious diseases. The clinical and pathologic differential diagnosis of this peculiar case is discussed, together with a brief review of the literature.
Pleomorphic adenoma of the palate in a child
Authors: Austin John R. , Crockett Dennis M. 
Published: February 2007

AbstractPleomorphic adenoma of the palate is a rare entity in childhood. Only 4 cases of this lesion are documented in detail in the literature. We present a patient with this lesion and discuss the usefulness of magnetic resonance imaging (MRI) in the preoperative evaluation. A review of the previously reported cases is provided along with a discussion of the treatment of this lesion.
Induction chemotherapy in head and neck cancer: Results of a phase III trial
Authors: Mazeron Jean‐Jacques , Martin Michel , Brun Bernard , Grimard Laval , Lelièvre Gilles , Vergnes Laurence , Haddad Elias , Feuilhade Frank , Piedbois Pascal , Strunski W. , Peynègre Roger , Pierquin Bernard , Bourgeois Jean‐Paul Le 
Published: February 2007

AbstractBetween December 1982 and October 1986, 131 patients with stage II‐III‐IV squamous cell carcinoma of the oropharynx or oral cavity were randomized to induction chemotherapy, consisting of bleomycin (10 mg/m2/day in continuous infusion from day 1 to day 5), methotrexate (120 mg/m2on day 2) followed by folinic acid, 5‐fluorouracil (5 FU) (600 mg/m2on day 2), and cisplatin (120 mg/m2on day 4) every 4 weeks for a total of three cycles followed by definitive locoregional treatment versus locoregional treatment alone. The modalities of definitive treatment (radiotherapy ± surgery) were chosen prior to randomization. A total of 116 patients were evaluable. Of 55 patients in the chemotherapy arm, four (7%) had a complete response (CR) and 23 (42%) a partial response (PR) following the induction regimen. At the completion of locoregional treatment, 76% (42 of 55) of patients in the experimental group were in CR compared to 89% (54 of 61) in the control group. There was no difference in survival, cause‐specific survival, and pattern of relapse between both groups. The median survival was 22 months in the chemotherapy group and 29 months in the control group. Responders to chemotherapy did not fare better than nonresponders. Chemotherapy‐related toxicities were few and most of them related to cisplatin which was reduced to 100 mg/m2for 35 patients. There were no treatment‐related deaths and, in the experimental arm of the trial, no increased morbidity from locoregional treatment. This induction regimen does not offer any advantages over standard treatment.
Pectoralis major myocutaneous flap: Analysis of complications in a VA population
Authors: Huang Robert D. , Silver Steven M. , Hussain Akhtar , Parnes Steven M. , Wing Paul D. 
Published: February 2007

AbstractForty‐five cases of head and neck reconstruction with pectoralis major myocutaneous flaps (PMMF) between 1985 and 1990 were analyzed retrospectively for complications. Thirty‐two cases were done at the VA Medical Center and 13 at Albany Medical Center, a private university hospital. Total complication rate was 58%. In the VA population, complication rate was 59% as compared to 54% at the Albany Medical Center, which appears statistically not significant. It has been suggested that VA populations tend to have poorer health and socioeconomic status and are more likely to have higher complication rates. This conjecture is not borne out by this study. Complications are described and compared.