bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gm ALLOTYPES AND MULTIPLE SCLEROSIS
Authors: Propert, D. N. , Bernad C. C. A. , Simons M. J. 
Published: April 2007

SUMMARYImmnoglobulin allotypes (Gm) were analysed in 40 multiple sclerois (MS) patients and the distribution of phenotypes compared to that in 1220 healthy controls. The frequencies of Gm(1) and Gm(1, 2) are significantly increased in the patietns suggesting that the presence of the Gm3;5,13,14haplotype confers a resistance to the development of MS.
IMMUNOCHEMICAL PROPERTIES OF HUMAN PLASMA α1 → 2 FUCOSYLTRANSFERASE SPECIFIED BY BLOOD GROUP H‐GENE
Authors: Yazawa S. , Furukawa K. 
Published: April 2007

SUMMARYA β‐galactoside α1 → 2 fucosyltransferase (H‐enzyme) from human group O plasma which provides H blood group specificity to erythrocyte membranes has been purified approximately 22,000‐fold by chromatography on DEAE‐Sepharose CL‐6B, GDP‐hexanolamine‐Sepharose 4B and SP‐Sephadex C‐50. The molecular weight of the H‐enzyme was estimated to be 150,000 by gel filtration. Human group O erythrocyte membranes which had lost their H blood group activity by the action of α1 → 2 fucosidase were fucosylated by the transferase, and restored the H activity. Radioactive L‐fucose appeared to be incorporated into glycolipid blood group substances of erythrocyte membranes. The activity of the α1 → 2 fucosyltransferase from human plasma, stomach mucosa, erythrocyte membranes and porcine stomach mucosa were specifically inhibited by the rabbit antiserum immunized with the preparation of human plasma H‐enzyme. The anti‐plasma H‐enzyme antiserum did not inhibit the activities of α1 → 3 N‐acetygalactosaminyltransferase (A‐enzyme), α1 → 3 galactosyltransferase (B‐enzyme), and β‐N‐acetylglucosaminide α1 → 3 and α1 → 4 fucosyltransferases from human plasma and stomach mucosa.
IMMUNOCHEMICAL EVIDENCE FOR MULTIPLE CLASS I ANTIGENS CODED BY THE MHC OF THE RAT (RT1) AND THEIR DIFFERENTIAL EXPRESSION ON RED BLOOD CELLS AND LYMPHOCYTES
Authors: Misra D. N. , Kunz H. W. , Gill T. J. 
Published: April 2007

SUMMARYFive monoclonal antibodies reacting with class I MHC antigens were produced by fusing lymphocytes from WF (RT1u) rats immunized against DA (RT1a) rats with P3‐X63‐Ag8‐653 myeloma cells. Sequential immunoprecipitation studies with the mAb and the WF anti‐DA alloantiserum demonstrated the presence of four different class I molecules: all four molecules were reactive with the alloantiserum; three of them contained the determinant for mAb 155; two of the latter three molecules shared the determinants for mAb 3, 56 and 60, and one of these two molecules also contained the determinant for mAb 118. The four molecules could be isolated from the antigen preparation by sequential immunodepletion first with 118, next with 3, then with 155 and finally with the alloantiserum or by sequential absorption with affinity columns of Sepharose 4B coupled to the antibodies. The three antigens which were sequentially isolated with the mAb 118, 3, and 155, respectively, were analysed by SDS‐PAGE after digestion with Staphylococcus aureus V8 protease, and they showed differences in peptide patterns. The relative amounts of the antigens expressed on red blood cells and on lymphocytes were different based on the results of sequential isolation and indirect cellular radioimmunoassay: the antigen which reacted with both mAb 3 (and 56 or 60) and 155 was the major class I antigen on red blood cells, and the antigen which reacted with mAb 118, 3 (and 56 or 60) and 155 was the major class I antigen on lymphocytes.
MAP OF MAJOR HISTOCOMPATIBILITY COMPLEX SUBREGIONS INFLUENCING VAGINAL SEPTA FREQUENCY
Authors: Bonner J. J. , Tyan M. L. 
Published: April 2007

SUMMARYThe frequency of dorso‐ventral vaginal septa (DVS) in mice in influenced by genes associated with the major histocompatibility complex, H‐2. Data shows that two subregions within the H‐2 complex, K‐Eβ and D, have a very strong influence on the frequency, while the Eβ‐S subregion appears to have a weak effect.
HUMAN ‘Ia’ ANTIGEN POPULATIONS DEFINED BY MONOCLONAL ANTIBODIES
Authors: Sparrow Rosemary L. , McKenzie I. F. C. 
Published: April 2007

SUMMARYThe relationships between the antigens recognized by four monoclonal anti‐human ‘Ia’‐like antibodies were investigated using sequential immunoprecipitation and capping techniques. Two of the antibodies were ‘monomorphic’ and have previously been shown to recognize epitopes in which carbohydrate residues are involved, whereas the two ‘polymorphic’ antibodies recognized protein‐defined epitopes—one of these epitopes being present on MB+DR‐ molecules. In the absence of an indisputable anti‐DR monoclonal antibody, it was not possible to conclusively verify which ‘Ia’‐encoded antigens were detected by the anti‐‘Ia’‐like monoclonal antibodies. Nevertheless, several firm conclusions could be drawn: (a) so‐called ‘monomorphic’ antibodies do not necessarily react with all ‘Ia’ molecules encoded by a single locus—from the results using the two monomorphic antibodies, B5.1 and 3F1.1, described herein, two populations of antigens being B5.1+3F1.1+ and B5.1+3F1.1‐ were identified; (b) cross‐reactivity of a polymorphic determinant expressed on antigenically‐separable ‘Ia’ molecules was noted—using the two polymorphic antibodies, 26.1 and F5C9, molecules which were 26.1+F5C9+ and 26.1‐F5C9+ were identified; and (c) the data clearly point to the existence of at least two loci coding for ‘Ia’‐like antigens (one of which may or may not be the HLA‐DR locus). Given that polymorphisms can now include protein‐ and carbohydrate‐defined epitopes, that cross‐reactions occur and that the definition of DR itself by monoclonal antibodies is not clear, the complexity of the human ‘Ia’ antgens is apparent.
HLA IN FAMILIAL HODGKIN'S DISEASE
Authors: Conte R. , Lauria F. , Zucchelli P. 
Published: April 2007

SUMMARYWe report HLA genotypes in four familial cases of Hodgkin's disease (HD), Nodular Sclerosis (NS) histological subtype, where all patients showed B18 antigen. This finding, although statistically not supported, confirms the possible correlation between HD and B18 antigen which carries a high relative risk in international data.
GENETIC CONTROL OF MOUSE ANTIBODY PRODUCTION TO HUMAN THYROGLOBULIN
Authors: Aihara Y. , Sakata S. , Nakamura S. , Kamikubo K. , Tarutani O. , Yamada S. , Tadokoro I. , Okuda K. 
Published: April 2007

SUMMARYGenetic control of immune responses in mice against human thyroglobulin was studied using the enzyme‐linked immunosorbent assay and passive haemagglutination test. Our results revealed that mice of H‐2a, H‐2d, H‐2q, H‐2k and H‐2r haplotypes were high responders for antibody production to human thyroglobulin, while mice of H‐2b and H‐2s haplotypes were low responders. High responsiveness to human thyroglobulin was transmitted to F1 mice in a dominant fashion. Study of the genetic mapping of the immune responses to human thyroglobulin using various congenic mice showed thatI‐A subregion gene(s) control the immune response to human thyroglobulin.
EVIDENCE FOR THE EXISTENCE OF A DIVERSE FAMILY OF IMMUNOGLOBULIN‐RELATED RECOGNITION MOLECULES
Authors: Warr, G. W. , Vasta, G. R. , Ledford,and B. E. , Marchalonis J. J. 
Published: April 2007

SUMMARYAll classes of molecule postulated to play a role in recognition or to have some structural homology to immunoglobulins were compared by the SΔQ index of differences in amino acid composition. The results suggest that there is a wide family of immunoglobulin‐related molecules that includes vertebrate immunoglobulins, T cell receptors, MHC products, C‐reactive proteins, and (some) invertebrate lectins.
HLA AND REPRODUCTION?
Authors: Giphart,and M. J. , D'Amaro J. 
Published: April 2007

SUMMARYIn mice it has been shown that mating preference is genetically associated with the Major Histocompatibility Complex (MHC). In the present study, an approach is described to study homologous aspects of the MHC in man.After selection of families with one or more children, a given parental HLA antigen was selected and the frequencies of the spouse's HLA antigens were determined. Assuming a random distribution, these frequencies should not be statistically different from those of the total population.Evidence is presented that this distribution is not random for a number of maternal and paternal HLA antigens.
GENETIC CONTROL OF PQ PROLONGATION OF THE ELECTROCARDIOGRAM IN THE MOUSE IMMUNIZED WITH THE KILLED GROUP A STREPTOCOCCI
Authors: Matsunaga K. , Tani K. , Katoh K. , Ishigatsubo Y. , Iwaku T. , Tadokoro,and I. , Okuda K. 
Published: April 2007

SUMMARYGenetic control of PQ prolongation of the electrocardiogram (ECG) in the mouse, immunized with killed group A streptococci, was studied by using various congenic mice. Mice of H‐2a, H‐2k and H‐2f haplotypes showed high frequencies of PQ prolongation, while haplotypes of H‐2b, H‐2d and H‐2s showed low frequencies of PQ prolongation. Studies using various recombinant mice revealed that at least one immune‐associated (Ir) gene mapped in the left side of the I‐B subregion. High responsiveness of F1 hybrids of H‐2b and H‐2d, as well as B1O.A(5R) and B10.A(3R), suggests the existence of a complementing gene. In addition, the differences between C3H and CKB, as well as differences between C3H.SW and CWB, indicate that another Ir gene maps in the immunoglobulin heavy chain (Igh) coding loci. Repeated injections of anti‐I‐J or anti‐I‐A antisera also modified this PQ prolongation. These results suggested that both the major histocompatibility complex (MHC) and immunoglobulin (Igh) loci seem to be playing important roles in the pathogenesis of PQ prolongation.
A MONOCLONAL ANTIBODY RELATED TO THE HUMAN BLOOD GROUP GERBICH
Authors: Daniels,* G. L. , Banting† G. , Goodfellow† P. 
Published: April 2007

SUMMARYThe monoclonal antibody, GERO, agglutinated all samples of red cells with the exception of Gerbich‐negative cells of both Ge and Yus types. Using the antiglobulin test, Gerbich‐negative cells reacted as strongly with GERO as did Gerbich‐positive cells.
AN APPROACH TO STUDY IN VITRO THE EXPRESSION OF HLA‐ENCODED GENETIC FACTORS PREDISPOSING TO TUBERCULOID LEPROSY
Authors: Van Eden W. , Elferink D. , Vries R. R. P. De 
Published: April 2007

SUMMARYThe existence of HLA‐encoded genetic factors controlling susceptibility to tuberculoid leprosy in humans has been firmly established. Furthermore HLA‐DR2 has been recognized as a marker for tuberculoid leprosy in India. At this moment, however, the gene products involved and the mechanism by which they confer susceptibility to tuberculoid leprosy remain only speculative. In an attempt to detectin vitrothe expression of these HLA‐encoded factors, we studied 12 tuberculoid leprosy patients and 22 healthy family members in a lymphocyte transformation test (LTT). All individuals were derived from multi‐case Indian families, previously reported to show the presence of HLA‐linked susceptibility genes. Although the responder‐status of the healthy contact siblings was shown to behave independently from the fact whether they were HLA‐identical with the patient‐siblings or not, some evidence forin vitroexpression of HLA‐DR2 associated factors could be obtained. Nevertheless, it is concluded that the standard LTT seems not to be a test‐system of first choice to detect thein vitroexpression of the genes under study.
LACK OF H‐2Ld LOCUS PRODUCTS ON A BALB/c FIBROSARCOMA EXPRESSING H‐2k‐LIKE ALIEN ANTIGENS
Authors: Ballinari, D. , Pierotti, M. A. , Sensi M. Luisa , Parmiani G. 
Published: April 2007

SUMMARYThe presence of H‐2Ld antigens was evaluated in methylcholanthrene‐induced BALB/c fibrosarcomas by a varity of approaches. Transplantation experiments showed that BALB/c‐H‐2dm2 mice, a mutant strain whose cells do not express H‐2Ld antigens, after immunization with BALB/c normal tissues developed a resistance to the growth of two tumours (C‐3 and GI‐17), but not to a third neoplasm, C‐1, which is known to have H‐2d‐as well as H‐2k‐like alien antigens. In vitro experiments with cytotoxic T lymphocytes generated against Ld antigens confirmed a loss of Ld antigens on C‐1 but not on C‐3 tumour cells. Serological experiments with an anti‐Ld serum again revealed the presence of H‐2Ld determinants on C‐3 but not on C‐1 cells. Biochemical analysis in SDS‐PAGE of immunoprecipitates obtained by specific anti‐H‐2 sera with NP40 lysates of the tumours studied could detect H‐2Kd, H‐2Dd and H‐2Ld antigens in C‐3 fibrosarcoma cells whereas Kd and Dd were the only H‐2d molecules found in C‐1 lysate along with the H‐2k‐like specificities. The possible genetic mechanisms which may explain this apparent gain and loss modification of the H‐2 profile of C‐1 are discussed.
ADULT TRANSPLANTATION TOLERANCE INDUCED BY LENTIL LECTIN: III. INDUCTION OF TRANSPLANTATION TOLERANCE BY LENTIL LECTIN IN MOUSE STRAIN COMBINATIONS WITH DIFFERENT H‐2 DISPARITIES: TOLEROGENIC EFFECT OF H‐2D REGION ANTIGENS
Authors: Hilgert I. , Krištofová H. , Angelisová P. , Kinský R. , Hořejší V. 
Published: April 2007

SUMMARYThe survival time of skin allografts was investigated in 28 combinations of mouse strains differing at various loci, in adult recipients treated with lentil seed lectin (LCA). The recipients were given 1 mg of LCA daily (i.v. or i.p.) after transplantation of the skin graft. The immunosuppressive effect of LCA was generally inversely related to the conventional strength of the allotransplantation reaction, i.e. the rate of rejection of allografts on untreated recipients. In the case of H‐2D antigenic disparities, the grafts usually survived for more than 100 days. The H‐2A or H‐2K disparity appeared to be relatively resistant to induction of tolerance by LCA treatment. The relative resistance of various H‐2 antigens toward the induction of tolerance by LCA differs to some extent from that observed in experiments on the induction of neonatal tolerance by semiallogeneic lymphocytes as described in literature.
POLYMORPHISM OF THE COMPLEMENT COMPONENT C6 IN JAPANESE
Authors: Tokunaga K. , Yukiyma Y. , Omoto K. 
Published: April 2007

SUMMARYGenetic polymorphism of human C6 was investigated in Japanese using isoelectric focusing and a specific haemolytic overlay method. Three common and six rare allotypes were identified. Five of these nine allotypes were reference‐typed by the International Reference Laboratory. Five of the six rare allotypes were considered to be new. The allele frequencies were estimated in the population study as follows: C6 A 0.427, C6 B 0.483 C6 B2 0.076, and the rere alleles (A3, A21, M1, M2, B3, and B4) 0.041.Inheritance of the three common and the two rare (A3 and M1) allotypes was demonstrated in the family study. The patterns obtained by the pretreatment with neuraminidase are presented.
CHARACTERIZATION OF AN ANTIGEN PRESENT ON TESTICULAR CELLS AND PRE‐IMPLANTATION EMBRYOS WHOSE EXPRESSION IS MODIFIED BY THE t12 HAPLOTYPE
Authors: Cheng Cecilia C. , Sege Karin , Alton Althea K. , Bennett Dorothea , Artzt Karen 
Published: April 2007

SUMMARYIn attempts to identify cell surface molecules specified by lethal genes in the T/t‐complex, we prepared a rabbit antiserum that has cytotoxic activity against testicular cells from males heterozygous for t12, but not against wild type cells. However, anti‐t12 serum immunoprecipitates the same major component, a glycoprotein of mol. wt. 87,000 daltons, from galactose‐labelled C3H.+/t12 testicular cell lysate and from congenic C3H.+/+ lysate, although the gp87 molecule precipitated from +/t12 cells appears to be more highly galactosylated than the +/+ form. The antigen is heavily glycosylated in both genotypes, since when testicular cells are treated with tunicamycin before immunoprecipitation, a protein of 40,000‐42,000 daltons is obtained.Gp87 is also present on pre‐implantation embryos, and on teratocarcinoma cells, but is barely detectable on any adult somatic cells examined. Its expression is developmentally regulated during pre‐implantation stages, but the temporal pattern of its expression appears to be different between wild type and t12 embryos. Thus, we believe we have identified a molecule that may play a role in the differentiation of testicular cells and pre‐implantation embryos, and that is either specified by genes in the t12 haplotype, or responsive in some way to the effects of t12.
FINE SPECIFICITIES OF THE MURINE T CELL RESPONSES TO (GLU LYS ALA) TERPOLYMERS
Authors: Lai Chang‐Hai , Babu Uma Mahesh , Maurer Paul H. 
Published: April 2007

SUMMARYThe T cell proliferative responses to GLA terpolymers among of H‐2 a, b, d, k, q, r, and s haplotypes are heterogeneous. Following immunization with GLA20, GlA40 and GLA60, mouse T cells reacted well with the three terpolymers. The cross‐reactions of the above T cells to GLA5 decreased as the alanine content in the terpolymers (immunogens) increased, whereas the trend of the cross‐reaction to GA40 did not change. The RIII strain showed no cross‐reaction with GLA5. Only mice of H‐2 haplotypes q and s failed to show cross‐reactions to GA40. Mice of the H‐2q haplotype are genetic non‐responders to GA40, wheras those of the H‐2s haplotype are reponders. Immunization of SJL mice with GA40 mixed with GLA40 led to reduction of the specific T cell reposne to GA40. This reduction of GA40 specific T cell responses in SJL mice by GLA40occurred during the early stage of the immune resonse. The kinetic study showed that is was necessary to inject the GLA40 intraperitoneally at least 7 days before GA40 in order for the reducion to take place. The PETLES and lymph node T cells from DBA/1 mice were found to respond to GLA40 differently, and these cells from SJL mice responded differently to GA40
SHORT COMMUNICATIONS: THE Wrb ANTIGEN IN Sta‐POSITIVE AND DANTU‐POSITIVE HUMAN ERYTHROCYTES
Authors: Ridgwell K. , Tanner M. J. A. , Anstee D. J. 
Published: April 2007

SUMMARYImmunoprecipitation using a monoclonal antibody showed that the Wrb antigen is present on the abnormal (δ‐α) hybrid sialoglycoprotein of Sta‐positive human erythrocytes but not on the abnormal (δ‐α) hybrid sialoglycoprotein of Dantu‐positive erythrocytes. These results provide further information regarding the nature and location of the Wrb antigen on the normal erythrocyte sialoglycoprotein α.
THE SPECIFIC IgM RESPONSE IN RATS GENETICALLY SELECTED FOR HIGH OR LOW SERUM IgM LEVEL
Authors: Hirsch François , Platteau Bernadette , Bazin Hervé 
Published: April 2007

SUMMARYThe IgM response to SRBC in a line of rats selected for high serum IgM was higher and lasted longer than that in a line of rats selected for low IgM, while the response to TNP‐LPS was similar at its peak in the two lines but persisted longer in the ‘high’ line. The difference between the lines is therefore more likely to be at the macrophage and/or the T cell level than at the B cell level.
ALIEN ANTIGENS ON TUMOUR CELLS REVISITED
Authors: Pierotti M. A. , Parmiani G. 
Published: April 2007

SUMMARYNew findings on the detection of alien histocompatibility antigens (AHA) on tumour cells are reviewed. Three points are discussed, namely: (1) isolation and molecular characterization of AHA; (2) frequency of expression of AHA by tumour cells, and (3) mechanisms of expression of AHA. Mechanisms of expressions of AHA are particularly discussed in the light of the recent advances in the understanding of the molecular genetic organization of H‐2 antigens. Gene conversion involving coding or non‐coding sequences might be responsible for the appearance of unexpected H‐2 determinants on cancer cells.
H‐2 CONTROL OF POLYADENYLATED mRNA PRODUCTION IN THE SPLEEN OF MICE INJECTED WITH BRUCELLA ANTIGENS
Authors: Pierrez J. , Guerci O. , Oth D. 
Published: April 2007

SUMMARYRNA was extracted from the splenocytes of Brucella abortus antigen stimulated mice and of control mice. The proportion of chromatographically separated polyadenylated 11.2S mRNA, was determined. With the technique used, only stimulated mice exhibited significant amounts of this RNA species. The highest level was reached 1 day after the stimulation, and the decay from this level presented an oscillatory form during the 4 weeks following the injection.In two different genetic backgrounds, H‐2b mice did not respond to the stimulus, in contrast to H‐2a and H‐2f mice. H‐2b/H‐2f heterozygotes behaved roughly as intermediate between H‐2b and H‐2f mice. This genetic control seems to parallel the genetic control of some Brucella‐induced, thymus‐dependent events previously described.
HLA, IMMUNOGLOBULIN ALLOTYPES AND CELL‐MEDIATED IMMUNITY IN RETINITIS PIGMENTOSA: A FAMILY STUDY
Authors: Galbraith G. M. P. , Pandey J. P. , Fudenberg H. H. , Ferrara G. B. 
Published: April 2007

SUMMARYInvestigation of an informative family including two probands with male multiplex retinitis pigmentosa revealed that the putative disease susceptibility loci were not linked to those of HLA. In addition, analysis of immunological data obtained yielded evidence suggestive of X‐linked inheritance of susceptibility to cell‐mediated immune aberration in this family.
ASSOCIATION BETWEEN LEPROSY AND IMMUNOGLOBULIN ALLOTYPES: Gm‐A2m AND Km FREQUENCIES IN VIETNAMESE
Authors: Lange Gerda de , Wright Pamela , Eede Peter van , Leeuwen Fred van , Long Hoang, Thuy , Hong Nguyen Thi Diem 
Published: April 2007

SUMMARYThe relationship between immunoglobulin allotypes and leprosy was studied in 91 unrelated patients and 100 healthy controls from Vietnam. Twenty Vietnamese patients with tuberculosis were also typed for the Gm, A2m and Km allotypes. The results were compared with those from the healthy controls. No significant association was found for the allotypes G1m(z,a,x,f) G2m(n), G3m(g,b), A2m(1,2) and Km(1,3) between the two groups of patients and the controls. Heterogeneity in the distribution of G2m(n), G3m(b), A2m(2) and Km(3) was found when 60 polar‐lepromatous (LL) patients and 27 borderlinetuberculoid (BT) patients were separated out of the 91 leprosy patients. In the LL patients there appeared to be a significantly higher frequency of G2m(n), G3m(b) and A2m(2) in co&#x006d;́parison with the BT patients (P < 0.05). A significantly lower frequency of Km(3) was found in the LL patients in comparison with the healthy control group (P < 0.05). The frequencies of the Gm‐A2m haplotypes and of the occurrence of the Km(1) and Km(3) in the Vietnamese population were calculated on the basis of the results in the 100 samples of healthy controls. The main haplotype is Gmaf;n;b (frequency 0.676), occurring with A2m1 (0.200), as well as with A2m2 (0.476)