bluuebunny/crossref_metadata_2025_split huggingface dataset:
Title:- Evaluation of comparative efficacy of Trisamagutika versus Kshargutika in management of Tundikeri (chronic tonsillitis) in children: A Randomized Controlled Clinical Study (Preprint)
Authors: Dhumale Dr Sonali , Rathi Dr Renu , Rathi Dr Bharat 
Published: February 2024

BACKGROUND

•	Tonsillitis is more common in children between 5 to 15 years ( more in 4 to 8 years.).There are 7,455,494 cases of tonsillitis and 2,00,000 tonsillectomies are performed in India per year. The incidence of this disease is about 7% of all visits to the paediatrician. Tundikeri is one of the Urdhwajatrugat Roga (diseases of Head and neck) mentioned by Acharya Sushrut, Vagbhata. Tonsillitis and Tundikeri can be correlated as both have the same features. Any infection in a growing child affects the immune system Repeated attacks of tonsillitis hampers routine growth and development also. Lastly, a radical cure for recurrent attacks is Tonsillectomy. Kshargutika from Charaksamhita is one of the formulations to treat kanthgat roga. The present study will be conducted to explore the efficacy of Kshargutika versus the efficacy of Trisamagutika in the management of chronic tonsilitis in children.

OBJECTIVE

1. To evaluate the comparative efficacy of Trisamagutika as standard control medicine versus Kshargutika in children with chronic tonsillitis on objective & Subjective parameters
2. To assess recurrence in terms of proportion in the reference of the control group ( Trisamagutika) and trial group(Kshargutika).

METHODS

Children with chronic Tonsillitis fulfilling inclusion criteria shall be randomly divided into two groups; 36 patients in each group. One group (P) will be given Trisamagutika and the other group (Q) will be given Kshargutika for 15 days orally B.D. Assessment will be done at 0,5,10 &15 th day. Followup will be taken every month for up to 1 year

RESULTS

Results will be drawn on the observations of subjective parameters.

CONCLUSIONS

The conclusion of the study will be drawn based on statistical data calculated from the collected data.

CLINICALTRIAL

- CTRI No.- CTRI/2023/08/056542
Dated- 16/08/2023
Дослідження ендотелію рогової оболонки у хворих із синдромом мілкої передньої камери при факоемульсифікації катаракти
Authors: Lavryk N.S. , Gurzhyi Y.M. , Shulezhko I.A. 
Published: February 2024

Актуальність. При синдромі мілкої передньої камери (СМПК) виникають певні складнощі при виконанні ФЕК, як відмітив L. Buratto (1999), що пов’язані з відсутністю достатнього простору для проведення маніпуляцій, а також з дією фізичних факторів. Відмічене можливе пошкодження ендотеліальних клітин (ЕК) рогівки, тому особливості ЕК відображають ступінь хірургічної травми. Мета: дослідити на очах хворих на катаракту із синдромом мілкої передньої камери залежність щільності ендотелію рогівки після операції факоемульсифікації від доопераційних глибини ПК та щільності ЕК та можливість збереження кількісних та якісних показників ендотелію рогівки. Матеріали та методи. Проаналізований стан 128 хворих на катаракту із СМПК, що були розділені на 2 групи: група 1 (61 око) — комбінована операція: задня мікровітректомія та ФЕК (КОЗМВЕФЕК; патент № 80762), група 2 (68 очей) — загальноприйнятий метод ФЕК. Обстеження до та після операції: візус, поле зору, внутрішньоочний тиск, біомікроскопія, сонографія; ЕК рогівки досліджували за допомогою ендотеліального мікроскопа SP-3000P (Topcon). Результати. Проведені дослідження показали, що ефективність КОЗМВЕФЕК та стандартної ФЕК суттєво не відрізняється. При порівнянні ускладнень відмічено, що через 1–3 місяці і 6–12 місяців після запропонованої операції КОЗМВЕФЕК (група 1) більшою мірою зберігається щільність ендотеліального шару рогівки: втрата ЕК менше в 2 рази (р < 0,05), менші прояви полімегатизму та поліморфізму ЕК (р < 0,05), ніж при стандартній ФЕК. Висновки. 1. Визначено залежність показника щільності ендотелію (ЕК) після операції від доопераційних глибини ПК (r = 0,54, p < 0,05) та щільності ендотелію (ЕК) до операції (r = 0,63, p < 0,05). Втрата ЕК після операції залежала від щільності ЕК до операції (r = 0,51, p < 0,05). Ці дані мають значення при плануванні хірургічного втручання. 2. Оцінюючи рівень травматичності хірургічного втручання на очах із СМПК, визначили, що умови маніпуляцій у ПК при КОЗМВЕФЕК та ФЕК за рахунок поглиблення ПК сприяли кращому збереженню ендотеліального шару рогівки, ніж при стандартній методиці ФЕК. Показники при порівнянні характеризують менш виражені прояви полімегатизму (р < 0,05) та поліморфізму (р < 0,05) ЕК рогівки при збереженні щільності клітин (р < 0,05).
Фактори ризику розвитку оклюзій артерій сітківки після кардіохірургічних втручань при клапанних вадах серця
Authors: Panchenko Yu.O. , Kovalchuk N.Ya. 
Published: February 2024

Актуальність. Є повідомлення про розвиток оклюзії центральної артерії сітківки (ОЦАС) після інвазивних серцево-судинних процедур. Хірургічне втручання, операція на відкритому серці та післяопераційна кровотеча підвищували ризик ОЦАС. У кардіохірургії виокремлюють певні фактори ризику для ОЦАС, як-от: гігантоклітинний артеріїт, каротидний стеноз, інсульт, стан гіперкоагуляції, цукровий діабет з офтальмологічними ускладненнями, гострий коронарний синдром, фібриляція передсердь, застійна серцева недостатність, а також куріння. Матеріали та методи. Під спостереженням перебувало 380 пацієнтів (760 очей) із клапанною патологією серця після кардіохірургічних втручань. Проводилося дослідження характеру, частоти й особливостей розвитку та клінічного перебігу оклюзій артерій сітківки у цих хворих. Для виявлення факторів ризику розвитку оклюзій артерій сітківки у пацієнтів із клапанними вадами серця після кардіохірургічних операцій була вивчена залежність їх частоти від статі, віку, виду оперативного втручання, типу протеза серцевого клапана й операційного доступу. Результати. Частота артеріальних оклюзій сітківки після проведених кардіохірургічних втручань протягом 1 року спостережень у середньому становила 11,12 % (χ2 = 173,645; p < 0,001). При аналізі типів артеріальних оклюзій зафіксовано розвиток усіх типів оклюзій на 3-тю добу. На 10-ту добу та через 3 місяці спостерігалася тільки оклюзія ЦАС — 0,66 і 0,41 % відповідно. Через 1 рік було діагностовано тільки оклюзію гілки ЦАС — 0,32 %. Частота артеріальних оклюзій вища втричі у пацієнтів з віковим проміжком від 51 до 70 років і вдвічі у пацієнтів віком понад 71 рік порівняно з пацієнтами вікового діапазону 50 років і молодше (p = 0,042); після протезування клапанів частота оклюзій удвічі вища (p = 0,034), ніж після пластики; при використанні механічних імплантів частота оклюзій артерій сітківки збільшується на 62 % (p = 0,010) порівняно з біологічними імплантами; при використанні класичного доступу під час операції частота оклюзій артерій сітківки статистично значуще вища на 35 % порівняно з мінідоступом та в 11 разів порівняно з доступом через стегнову артерію (р < 0,001).
Genetic Insights: Examining CNTNAP2 rs7794745 Gene Polymorphism and Its Impact on ABLLS Assessment in Middle Euphrates Children in Iraq with Autism Spectrum Disorder
Authors: AL-Safar Safaa R. M. , AL-Zubaidy Haydar F. S. , Alwaidh Roaa Hameed 
Published: February 2024

Objective: examine the effect of CNTNAP2 gene polymorphism on behavioral therapy response in Iraqi children with autism spectrum disorder using ABLLS-r.
Methods: In this study, 150 samples for autism spectrum disorder were obtained from AL-SIBTEIN ACADEMY, however owing to many challenges, the final number of samples was 50 patients. Polymerase Chain Reaction-Restriction refers to a technique that combines the use of polymerase chain reaction (PCR) with restriction enzymes to amplify and analyze certain DNA sequences. Fragment Length Polymorphism (PCR-RFLP) was used to genotype the CNTNAP2 gene at rs7794745. All 25 ABLLS-R repertoires and all four primary components had their dependent parameters determined by aggregating and converting the ABLLS data to a percentage. This provided us with the proportion of finished assignments from each repertoire.
Results: After correlating the genotype data (AA/AT/TT) with the behavioral therapy response as indicated by ABLLS-R, we only discovered a statistically significant difference between the frequency of AA/TT genotypes in the rs7794745 variant in patients and the social interaction domain. Conversely, the remaining 24 subdomains exhibited no discernible correlation.
Conclusion: This research topic could provide significant information on targeting and categorizing which skill areas need to be developed based on genetic models' influence.
Enhancing Cement Stabilization for Lateritic Soil in the Takie Area of Ogbomoso
Authors:   Department of Architecture University of Ibadan Ibadan, Nigeria, Obakin Olufunmilola Adetayo , Oladunmoye Oluranti Mobolaji 
Published: February 2024

The study investigates "Optimizing Cement Stabilization for Lateritic Soil in the Takie Area of Ogbomoso" and presents a comprehensive analysis of geotechnical properties. The research encompassed particle size determination and Atterberg limits testing to classify the samples, primarily composed of lateritic soil. The results detailed the particle size distribution and indicated the soil’s composition, predominantly sand with gravel and unaccounted finer silt content. The Atterberg limits testing revealed variations in plastic and liquid limits across different cement percentages. Additionally, dynamic and static compaction tests were performed, indicating Optimum Moisture Content (OMC) and Maximum Dry Density (MDD). The static compaction involved replacing proportions of bulk sand with cement for each percentage addition. The study achieved its objective of understanding soil properties for stabilization purposes, offering insights into the impact of varying cement content on soil characteristics and compaction. The abstract emphasizes the comprehensive investigation into lateritic soil properties and the influence of cement stabilization, vital for engineering applications in the Takie area of Ogbomoso. Keywords: Lateritic Soil, Cement Stabilization, Geotechnical Properties, Atterberg Limits, Compaction	Testing Aims Research Journal Reference Format: Obakin, O.A. & Oladunmoye, O.M. (2022): Enhancing Cement Stabilization for Lateritic Soil in the Takie Area of Ogbomoso. Advances in Multidisciplinary and Scientific Research Journal Vol. 8. No. 4. Pp 1-10. www.isteams.net/aimsjournal. dx.doi.org/10.22624/AIMS/V8N4P1
The Impact of the CPA Evolution on Students’ Interest in Earning a CPA License and Working in Public Accounting
Authors: Johnson Tristan , Lang Bradley , Mauldin Shawn 
Published: February 2024

ABSTRACT
The CPA Evolution is a joint initiative of the AICPA and NASBA to ensure the continued relevance of the CPA exam and to increase CPA licensure. Beginning in January 2024, a core plus discipline approach requires all candidates to pass three core exam sections and one of three discipline sections. This study examines whether this new exam format affects an individual’s interest in earning the CPA license and working in public accounting. The results of an experiment suggest that the new exam format significantly increases interest in earning a CPA license and that this effect is driven by nonaccounting major students who have career preferences in the accounting profession. Additionally, the new exam format marginally increases interest in working in public accounting, specifically with nonaccounting majors with career preferences in accounting. Our results indicate the CPA Evolution may help address the current pipeline staffing shortages in the field of accounting.
Data Availability: Please contact the authors.
Loan-Level Disclosure and the Convenience Yield of Asset-Backed Securities
Authors: Schmidt Brent A. , Zhang Haiwen 
Published: February 2024

ABSTRACT
We examine the impact of transparency on the convenience yield of AAA-rated asset-backed security (ABS) tranches. AAA tranches of ABS are commonly held by investors to manage financial liquidity and therefore enjoy a price premium beyond what is determined solely by the expected monetary payoff (i.e., convenience yield). The Securities and Exchange Commission (SEC) requires ABS issuers to provide monthly disclosures about the performance of the underlying individual loans for ABS issued after November 23, 2016 to improve transparency. We document that AAA tranches of ABS experience a significant increase in price volatility after the loan-level disclosure mandate. As a result, the use of these tranches as collateral for short-term funding and their convenience yield decrease significantly after the increased disclosure. Our collective evidence highlights an important unintended consequence of increased transparency in the ABS market; it diminishes the pledgeability of long-term safe assets.
Data Availability: Data are available from the public sources cited in the text.
JEL Classifications: G14; G23; M48.
Effect of traditional rehabilitation programme versus telerehabilitation in adolescents with idiopathic scoliosis during the COVID-19 pandemic: a cohort study
Authors: Mantelatto Andrade Rodrigo , Gomes Santana Bruna , Verttú Schmidt Ariane , Eduardo Barsotti Carlos , Pegoraro Baroni Marina , Tirotti Saragiotto Bruno , Ribeiro Ana Paula 
Published: February 2024

Background: Telerehabilitation has become increasingly popular since the SARS-CoV-2 (COVID-19) outbreak. However, studies are needed to understand the effects of remote delivery of spine treatment approaches.
Objectives: To verify and compare the effects of traditional rehabilitation programmes (in-person) and telerehabilitation (online) on the progression of scoliotic curvature in adolescents with idiopathic scoliosis during the COVID-19 pandemic, and to verify the acceptability, appropriateness, and feasibility among patients and physiotherapists regarding both treatments.
Methods: This is a cohort study (prospective analysis of 2 intervention groups: telerehabilitation (online) and traditional rehabilitation (in-person). A total of 66 adolescents with idiopathic scoliosis were included. Recruitment was conducted through the Clinical Center in Scoliosis Care (January–December 2020). Participants were divided into 2 intervention groups: telerehabilitation (online) (n = 33) and traditional rehabilitation programme (in-person) (n = 33). Both groups also were supplied with a spinal orthopaedic brace. Scoliosis was confirmed by a spine X-ray examination (Cobb angle). Radiographic parameters measured were: Cobb angles (thoracic and lumbar). The method of Nash and Moe (thoracic and lumbar) was also evaluated based on the relationship between the vertebral pedicles and the centre of the vertebral body in the X-rays. Assessments were performed at baseline (T0) and after 6 months of the intervention protocol (T6). Patient and physiotherapist reports were evaluated on the acceptability, appropriateness, and feasibility of the interventions.
Results: Adolescents with idiopathic scoliosis showed a significant decrease in the Cobb angle (main scoliotic curvature), with a 4.9° for the traditional rehabilitation programme and 2.4° for the telerehabilitation. Thoracic and lumbar Cobb angles did not show significant changes after the intervention in both groups or between groups. Thoracic and lumbar Nash and Moe scores scores also did not show significant differences after 6 months of in-person or telerehabilitation intervention, or between groups. The intervention by telerehabilitation was acceptable, appropriate, and feasible for patients and physiotherapists.
Conclusion: Use of the rehabilitation programme for adolescents with idiopathic scoliosis, delivered via telerehabilitation during the COVID-19 pandemic, was encouraging for future applications due to the improved effect on reducing the Cobb angle, preventing progression of scoliosis. In addition, telerehabilitation showed good acceptability among patients and physiotherapists. Traditional rehabilitation programmes (in-person) in adolescents with idiopathic scoliosis also showed a reduction in the Cobb angle.
Penerapan Model Belajar Calistung untuk Meningkatkan Literasi dan Numerasi Siswa di Sekolah Dasar
Authors: Kusuma Alfianza Wijaya , Sari Christina Kartika 
Published: February 2024

Kemampuan literasi dan numerasi siswa Sekolah Dasar Negeri Galeh 1, khususnya untuk kelas 2 yang sebagian masih kesulitan dalam membaca, menulis, dan berhitung. Oleh karena itu, diperlukan model pembelajaran yang dapat mengurangi kendala tersebut. Penelitian ini bertujuan untuk (1) mendeskripsikan peran program pembelajaran calistung di Sekolah Dasar Negeri Galeh 1, dan (2) kendala dan solusi yang dialami guru dalam pembelajaran calistung. Jenis penelitian yang digunakan adalah penelitian kualitatif dan observasi dengan cara penerapan model pembelajaran calistung secara langsung di Sekolah Dasar Negeri Galeh 1. Berdasarkan penelitian yang telah dilaksanakan maka diperoleh hasil guru memberikan jam tambahan untuk penerapan program belajar calistung kegiatan belajar ini dilakukan di pada hari senin sampai sabtu pada saat jam istirahat, guru memberikan buku kepada siswa untuk dibaca, dan pengenalan angka dengan cara berhitung. Penerapan model pembelajaran calistung dinilai efektif dalam meningkan literasi dan numerasi peserta didik.
150 anos de investigação após a descoberta de Enrico Sertoli
Authors: Calado Ana Margarida 
Published: February 2024

Resumo
A complexa morfologia das células de Sertoli, bem como as suas interações com as células germinativas tem sido foco de investigação desde que a sua descrição pela primeira vez em 1865 por Enrico Sertoli. Nos últimos anos, a investigação no âmbito das células de Sertoli vai muito além da morfologia, da fisiologia e tornou-se cada vez mais focada nas questões moleculares. O objetivo dos investigadores tem sido entender o papel das células de Sertoli na espermatogénese e aplicar essa informação em problemas relacionados à fertilidade masculina. Os numerosos e distintos complexos juncionais e especializações de membrana entre as células de Sertoli e as células germinativas proporcionam um microambiente para o desenvolvimento das células germinativas, definindo dois compartimentos anatómica e fisiologicamente distintos no túbulo seminífero. As células de Sertoli constituem uma população de células que não se dividem, mas que se encontra ativa durante a vida reprodutiva, alterando ciclicamente a sua morfologia e a expressão génica de forma a contribuírem para o inicio da onda espermática e cooperação com a espermatogénese.
Esta revisão, destacaremos os principais avanços científicos relativos ao importante papel das células de Sertoli na espermatogénese, na diferenciação do testículo, na determinação do sexo e em questões clínicas que envolvem interação das células de Sertoli com células germinativas.
Palavras-chave: História da Ciência, Células de Sertoli, Enrico Sertoli, Espermatogénse, Testículo

Abstract
The complex morphology of Sertoli cells, as well as their interactions with germ cells, has been the focus of investigation since their first description in 1865 by Enrico Sertoli. In recent years, Sertoli cell research has gone far beyond morphology and physiology and has become increasingly focused on molecular issues. The researchers' goal has been to understand the role of Sertoli cells in spermatogenesis and to apply this information in problems related to male fertility. The numerous and distinct junctional complexes and membrane specializations between Sertoli cells and germ cells provide a microenvironment for germ cell development, defining two anatomically and physiologically distinct compartments in the seminiferous tubule. Sertoli cells constitute a population of cells that do not divide, but are active during reproductive life, cyclically changing their morphology and gene expression in order to contribute to the initiation of the sperm wave and cooperation with spermatogenesis. In this review, we will highlight the main scientific advances regarding the important role of Sertoli cells in spermatogenesis, testis differentiation, sex determination and clinical issues involving Sertoli cell interaction with germ cells.
Key Words: History of Science, Sertoli Cells, Enrico Sertoli, Spermatogenesis, Testis
A Química das Joias de Crioula valorização da história e cultura africana e afro-brasileira e o protagonismo das mulheres negras no Brasil
Authors: Matos Larissa Gomes , Lira Priscila , Antunes Ettore 
Published: February 2024

Resumo
A lei nº 10.639/2003 completou 20 anos em 2023 e representa uma importante vitória, principalmente para o movimento negro na luta pela igualdade e contra o racismo. A lei estabelece a obrigatoriedade do ensino da história e cultura africana e afro-brasileira nas escolas e universidades brasileiras, no entanto muitas são as dificuldades enfrentadas para sua implementação, sendo uma das principais à falta de material didático. Com vista a ajudar na superação destas dificuldades, o objetivo deste trabalho é apresentar a construção de uma proposta didática sobre o tema a Química das Joias de Crioula e a valorização da história e cultura das mulheres negras no Brasil, com base em uma educação multicultural interculturalista que se articula no desenvolvimento de políticas de igualdade com as políticas de promoção e construção de identidades sociais e o reconhecimento das diferenças culturais. Possibilitando o desenvolvimento de discussões sobre a utilização das joias como indumentária de poder econômico, político e social de mulheres negras nos períodos colonial e imperial no Brasil e a aprendizagem dos conteúdos e processos químicos envolvidos na produção de joias ao longo da história e dos trabalhos desenvolvidos por ferreiros africanos e afro-brasileiros e suas contribuições para o desenvolvimento da história da Química no Brasil.

Palavras-chave: História da Química; Joias de Crioula; Mulheres Negras
Abstract
Law nº 10.639/2003 completed 20 years in 2023 and represents an important victory, especially for the black movement in the fight for equality and against racism. The law establishes the mandatory teaching of African and Afro-Brazilian history and culture in Brazilian schools and universities, however there are many difficulties faced in its implementation, one of the main ones being the lack of didactic material (GONZAGA, MARTINS; RAYKIL, 2018 ). With a view to helping to overcome these difficulties, the objective of this work is to present the construction of didactic proposal on the theme the Chemistry of Creole Jewels and the appreciation of the history and culture of black women in Brazil, based on an interculturalist multicultural education that it is articulated in the development of equality policies with policies for the promotion and construction of social identities and the recognition of cultural differences (GANDAU, 2008). Enabling the development of discussions about the use of jewelry as an outfit of economic, political and social power for black women in the colonial and imperial periods in Brazil and the learning of the contents and chemical processes involved in the production of jewelry throughout history and the works developed by African and Afro-Brazilian blacksmiths and their contributions to the development of the history of Chemistry in Brazil.

Keywords: History of Chemistry; Creole Jewelry; Black Women