bluuebunny/crossref_metadata_2025_split huggingface dataset:
MRI and pathology comparisons in Rasmussen’s encephalitis: a multi-institutional examination of hemispherotomy outcomes relative to imaging and histological severity
Authors: Doherty Alexander , Knudson Kathleen , Fuller Christine , Leach James L. , Wang Anthony C. , Marupudi Neena , Han Rowland H. , Tomko Stuart , Ojemann Jeff , Smyth Matthew D. , Mangano Francesco , Skoch Jesse 
Published: March 2024

Abstract
Purpose
Rasmussen encephalitis (RE) is a very rare chronic neurological disorder of unilateral inflammation of the cerebral cortex. Hemispherotomy provides the best chance at achieving seizure freedom in RE patients, but with significant risks and variable long-term outcomes. The goal of this study is to utilize our multicenter pediatric cohort to characterize if differences in pathology and/or imaging characterization of RE may provide a window into post-operative seizure outcomes, which in turn could guide decision-making for parents and healthcare providers.

Methods
This multi-institutional retrospective review of medical record, imaging, and pathology samples was approved by each individual institution’s review board. Data was collected from all known pediatric cases of peri-insular functional hemispherotomy from the earliest available electronic medical records. Mean follow-up time was 4.9 years. Clinical outcomes were measured by last follow-up visit using both Engel and ILAE scoring systems. Relationships between categorical and continuous variables were analyzed with Pearson correlation values.

Results
Twenty-seven patients met study criteria. No statistically significant correlations existed between patient imaging and pathology data. Pathology stage, MRI brain imaging stages, and a combined assessment of pathology and imaging stages showed no statistically significant correlation to post-operative seizure freedom rates. Hemispherectomy Outcome Prediction Scale scoring demonstrated seizure freedom in only 71% of patients receiving a score of 1 and 36% of patients receiving a score of 2 which were substantially lower than predicted.

Conclusions
Our analysis did not find evidence for either independent or combined analysis of imaging and pathology staging being predictive for post peri-insular hemispherotomy seizure outcomes, prompting the need for other biomarkers to be explored. Our data stands in contrast to the recently proposed Hemispherectomy Outcome Prediction Scale and does not externally validate this metric for an RE cohort.
Cannabis use and cannabis use disorders and their treatment in the Europe
Authors: Hall Wayne , Manthey Jakob , Stjepanović Daniel 
Published: March 2024

AbstractThis paper introduces the special issue on cannabis use in Europe. It describes data on the prevalence of cannabis use in Europe and the more limited data on the prevalence of cannabis use disorders, one of the most common forms of drug problem treated in many countries in Europe. It summarises what research has indicated about the adverse effects of acute and chronic cannabis use and discusses potential health system responses that may reduce some of these harms. These include public education about the risks of cannabis use; screening and brief interventions in primary medical settings; and specialist treatment for cannabis use disorders. It briefly indicates the special issues that may need to be addressed in dealing with the high rates of comorbidity between cannabis use disorders, other types of drug use disorders, and common mental disorders.
A grain boundary model of metamorphic reaction
Authors: Spear Frank S. 
Published: March 2024

AbstractA model is presented whereby metamorphic parageneses are governed by local, nano-scale reactions among adjacent phases along grain boundaries that are driven by local disequilibrium between the solid phases and the grain boundary composition. These reactions modify the grain boundary composition setting up compositional gradients that drive diffusion and change the grain boundary composition elsewhere in the rock, which drive local reactions in these locations. The process may be triggered by the nucleation of a new phase that is out of equilibrium with the existing assemblage and an example is presented based on the transformation of kyanite (Ky) to sillimanite (Sil). Model results reveal that a simple polymorphic transformation (Ky→Sil) can result in local reactions among all phases in the rock and some phases may grow in one locale and be consumed in another. An implication of these results is that interpretation of metamorphic parageneses based on growth or resorption and compositional changes of phases requires careful evaluation of nano-scale processes.
Habitat modification by marram grass negatively affects recruitment of conspecifics
Authors: Lammers Carlijn , Schmidt Annika , van der Heide Tjisse , Reijers Valérie C. 
Published: March 2024

AbstractEcosystem engineers alter their environment often benefiting their own survival and growth yielding self-reinforcing feedbacks. Moreover, these habitat modifications have been found to facilitate recruitment of conspecifics for some species, while for others engineering inhibits recruitment. Whether dune grasses facilitate or inhibit recruitment of conspecifics is yet unknown. Here, we investigated how habitat modification by European marram grass (Ammophila arenaria) through embryonic dune development affects recruitment from seeds and marine dispersed rhizome fragments. Specifically, we tested at three locations with different dune morphologies how habitat modification affected natural seed and rhizome presence and shoot emergence from plots in which seeds or rhizome fragments were added. In addition, we investigated how sediment burial (i.e., the main effect of habitat modification by dune grasses) affected germination and emergence in a controlled experiment. Results show that regardless of habitat modification or beach width, seeds and rhizomes were absent in natural conditions. Habitat modification negatively affected shoot emergence from seeds (8 × less) and rhizomes (4 × less) and was negatively related to sediment dynamics. Furthermore, fewer seedlings were found with higher elevations. In controlled laboratory conditions, the highest seedling emergence was found with slight burial (0.5-3 cm); both germination and seedling emergence decreased as seeds were buried deeper or shallower. Overall, habitat modification by marram grass negatively affects recruitment of conspecifics through increased sediment dynamics and elevation. Consequently, storm events or eradication programs that include removal of adult vegetation—which leads to an unmodified system—might benefit new recruitment from seeds or clonal fragments.
Preoperative elastoplasty of aggressive vertebral hemangiomas in elderly patients: a new strategy for reducing intraoperative bleeding and complications
Authors: Lofrese Giorgio , Cultrera Francesco , Ricciardi Luca , Visani Jacopo , Tosatto Luigino , Ruggiero Maria , Haznedari Nicolò , Menetti Federico 
Published: March 2024

Abstract
Purpose
Preoperative elastoplasty could be an alternative strategy for treating aggressive vertebral hemangiomas (VHs) in frail patients needing for spinal cord decompression, combining the advantages of embolization and vertebroplasty.

Methods
Three elderly patients with spinal cord compression from thoracic aggressive VHs underwent XperCT-guided percutaneous injection of silicone (VK100), filling the whole affected vertebra, followed by a decompressive laminectomy. At 12-months follow-up no recurrences, vertebral collapse or segmental kyphosis were noted at the CT scans, with patients reporting an improvement of preoperative neurological deficits, VAS and Smiley-Webster pain scale (SWPS) parameters.

Results
With its elastic modulus, non-exothermic hardening, and lower viscosity than PMMA, VK100 allowed a preoperative augmentation of the affected vertebral body, pedicles, and laminae without complications, with a controlled silicone delivery even in part of VH’s epidural components thanks to XperCT-guidance.

Conclusion
When facing highly bony erosive VH encroaching the spinal canal, VK100 combines the advantages of embolization and vertebroplasty especially in elderly patients, permeating the whole VH’s angioarchitecture, significantly reducing tumor.
Reducing the wrapping effect of set computation via Delaunay triangulation for guaranteed state estimation of nonlinear discrete-time systems
Authors: Wan Jian , Jaulin Luc 
Published: March 2024

AbstractSet computation methods have been widely used to compute reachable sets, design invariant sets and estimate system state for dynamic systems. The wrapping effect of such set computation methods plays an essential role in the accuracy of their solutions. This paper studies the wrapping effect of existing interval, zonotopic and polytopic set computation methods and proposes novel approaches to reduce the wrapping effect for these set computation methods based on the task of computing the dynamic evolution of a nonlinear uncertain discrete-time system with a set as the initial state. The proposed novel approaches include the partition of a polytopic set via Delaunay triangulation and also the representation of a polytopic set by the union of small zonotopes for the following set propagation. The proposed novel approaches with the reduced wrapping effect has been further applied to state estimation of a nonlinear uncertain discrete-time system with improved accuracy. Similar to bisection for interval and zonotopic sets, Delaunay triangulation has been introduced as a set partition tool for polytopic sets, which has opened new research directions in terms of novel set partition, set representation and set propagation for reducing the wrapping effect of set computation.
Comparing pre- and postoperative etoricoxib administration versus only postoperative on third molar extraction sequelae and oral health quality of life: a prospective quasi-experimental study
Authors: La Rosa Giusy Rita Maria , Consoli Matteo , Abiad Roula S. , Toscano Angelo , Pedullà Eugenio 
Published: March 2024

Abstract
Objectives
This study aimed to compare the impact of pre- and postoperative etoricoxib administration versus only postoperative on third molar extraction sequelae and oral health quality of life.

Materials and methods
This prospective quasi experimental study involved 56 patients, divided into a study group receiving preemptive etoricoxib 120 mg before surgery and postoperative etoricoxib 120 mg (n = 28), and a control group receiving preemptive placebo before surgery and postoperative etoricoxib 120 mg (n = 28).
Follow-up assessments were conducted at 3- and 7-days post-surgery, recording swelling, trismus, and adverse events. Patients rated perceived pain using the visual analog scale (VAS) and completed an oral health-related quality of life (OHRQoL) questionnaire at specified intervals. Statistical analysis employed non-parametric tests (i.e., the Mann–Whitney test, Friedman test, and Wilcoxon sign test) with P < 0.05.

Results
Significantly lower VAS scores were reported in the study group throughout the follow-up period (P < 0.05). Pharmacological protocol did not have a significant impact on postoperative edema and trismus (P > 0.05). However, double etoricoxib intake significantly improved postoperative quality of life on day 3 after surgery (P < 0.05).

Conclusions
Pre- and postoperative etoricoxib 120 mg intake in third molar surgery reduced postoperative pain and enhanced postoperative quality of life on day 3 after surgery. Importantly, it was equally effective in managing swelling and trismus compared to exclusive postoperative intake.

Clinical Relevance
Preemptive etoricoxib use may decrease patient discomfort following impacted mandibular third molar extraction.
Neuronal Control of Posture in Blind Individuals
Authors: Helmich I. , Gemmerich R. 
Published: March 2024

AbstractThe control of posture is guided by the integration of sensory information. Because blind individuals cannot apply visual information to control posture as sighted individuals do they must compensate by the remaining senses. We therefore hypothesize that blind individuals alter their brain activation in the sensorimotor cortex during postural control to compensate for balance control without vision by the increased integration of somatosensory information. Ten blind and ten sighted (matched) individuals controlled posture during conditions with (I) eyes closed / open, and (II) stable / unstable surface conditions. Postural sway was recorded by applying a pressure distribution measuring plate. Brain activation was collected by functional Near InfraRed Spectroscopy (fNIRS) above motor-sensory cortices of the right and left hemispheres. Blind individuals showed significantly increased postural sway when balancing with open eyes on an unstable surface and when compared to sighted individuals. Whereas blind individuals showed significantly increased brain activation when balancing with open eyes on stable and unstable surface conditions, sighted individuals increased their brain oxygenation only during closed eyes and unstable surface conditions. Overall conditions, blind individuals presented significantly increased brain activation in two channels of the left and right hemispheric motor-sensory cortex when compared to sighted individuals. We therefore conclude that sighted individuals increase their brain oxygenation in the sensorimotor cortex during postural control tasks that demand sensory integration processes. Blind individuals are characterized by increased brain activation overall conditions indicating additional sensory integration during postural control. Thus, the sensorimotor cortex of blind individuals adapts to control posture without vision.
Sustainability Traps: Patience and Innovation
Authors: Dioikitopoulos Evangelos V. , Karydas Christos 
Published: March 2024

AbstractThis paper argues that the joint relation between long-term orientation, environmental quality and innovation plays a key role in explaining the economic and the environmental dimension of sustainability. In our model multiple equilibria of economic development and environmental quality can arise due to a trade-off between the demand for innovation that promotes sustainability, and the ephemeral pleasure from polluting manufacturing that impedes it. Additional to traditional policies such as aid and technology transfers, policies that target behavioral changes through environmental protection may provide a double-dividend of economic and environmental sustainability through an environment-patience-innovation channel.
Nonlinear Regression Modelling: A Primer with Applications and Caveats
Authors: O’Brien Timothy E. , Silcox Jack W. 
Published: March 2024

AbstractUse of nonlinear statistical methods and models are ubiquitous in scientific research. However, these methods may not be fully understood, and as demonstrated here, commonly-reported parameter p-values and confidence intervals may be inaccurate. The gentle introduction to nonlinear regression modelling and comprehensive illustrations given here provides applied researchers with the needed overview and tools to appreciate the nuances and breadth of these important methods. Since these methods build upon topics covered in first and second courses in applied statistics and predictive modelling, the target audience includes practitioners and students alike. To guide practitioners, we summarize, illustrate, develop, and extend nonlinear modelling methods, and underscore caveats of Wald statistics using basic illustrations and give key reasons for preferring likelihood methods. Parameter profiling in multiparameter models and exact or near-exact versus approximate likelihood methods are discussed and curvature measures are connected with the failure of the Wald approximations regularly used in statistical software. The discussion in the main paper has been kept at an introductory level and it can be covered on a first reading; additional details given in the Appendices can be worked through upon further study. The associated online Supplementary Information also provides the data and R computer code which can be easily adapted to aid researchers to fit nonlinear models to their data.
A more direct way to the Cauchy problem for effectively hyperbolic operators
Authors: Nishitani Tatsuo 
Published: March 2024

AbstractThis paper is devoted to a simpler derivation of energy estimates and a proof of the well-posedness, compared to previously existing ones, for effectively hyperbolic Cauchy problem. One difference is that instead of using the general Fourier integral operator, we only use a change of local coordinates x (of the configuration space) leaving the time variable invariant. Another difference is an efficient application of the Weyl-Hörmander calculus of pseudodifferential operators associated with several different metrics.
Non-Coding Ribonucleic Acids as Diagnostic and Therapeutic Targets in Cardiac Fibrosis
Authors: Olson Samuel R. , Tang W. H. Wilson , Liu Chia-Feng 
Published: March 2024

Abstract
Purpose of Review
Cardiac fibrosis is a crucial juncture following cardiac injury and a precursor for many clinical heart disease manifestations. Epigenetic modulators, particularly non-coding RNAs (ncRNAs), are gaining prominence as diagnostic and therapeutic tools.

Recent Findings
miRNAs are short linear RNA molecules involved in post-transcriptional regulation; lncRNAs and circRNAs are RNA sequences greater than 200 nucleotides that also play roles in regulating gene expression through a variety of mechanisms including miRNA sponging, direct interaction with mRNA, providing protein scaffolding, and encoding their own products. NcRNAs have the capacity to regulate one another and form sophisticated regulatory networks. The individual roles and disease relevance of miRNAs, lncRNAs, and circRNAs to cardiac fibrosis have been increasingly well described, though the complexity of their interrelationships, regulatory dynamics, and context-specific roles needs further elucidation.

Summary
This review provides an overview of select ncRNAs relevant in cardiac fibrosis as a surrogate for many cardiac disease states with a focus on crosstalk and regulatory networks, variable actions among different disease states, and the clinical implications thereof. Further, the clinical feasibility of diagnostic and therapeutic applications as well as the strategies underway to advance ncRNA theranostics is explored.
Evaluation of the current technologies used for the physical security and safety of selected railway tunnel portals as a case study in the Czech Republic
Authors: Smažinka Dalibor , Kavan Štěpán , Hrinko Martin 
Published: March 2024

Abstract
The security and safety of the railway tunnels require technical measures, information processes, and trained experts. Proper implementation and integration of these elements is crucial to protect lives, property, and the operation of the rail network. The purpose of this study is to identify and describe technological security and safety measures at the portals of selected railway tunnels greater than 1000 m in the conditions of the Czech Republic and their subsequent evaluation. The method of semi-structured interviews with experts with experience in the implementation of security and safety measures was used for the elaboration. SWOT analysis was used to assess the safety level of selected railway tunnels. The evaluation was carried out based on multi-criteria decision making and pairwise evaluation on the principle of Fuller’s triangle. The technical solutions of two currently known technological solutions in the case study for accident elimination based on lidar detection supplemented by cameras are characterized by fundamental differences. The solution in the Ejpovice tunnel focuses on the detection of objects in the immediate vicinity of the portal or already entered it. The solution in the Březenský tunnel focuses on a larger detection zone extending tens of meters in front of the tunnel portal and is divided into two parts with different logic, the pre-alarm and the alarm itself. Integration of individual elements into a proactive and automated system that uses modern AI-based analytical algorithms and respects the process and technology specifics of the railway environment is important for the safety and security of the railway tunnel.
Discussion on the Relationship Between Chinese Government’s Investment in Health Human Capital and Economic Growth
Authors: Shuyong Fu , Shuyu Chen , Maimaituxun Miyeseer 
Published: March 2024

Abstract
In the past decade, the Chinese government has been facing a series of economic difficulties. The policies introduced by the Chinese government not only aim to maintain economic growth but also to achieve stable monetary and fiscal policies. In addition, the three-year pandemic has put greater financial pressure on the Chinese government. However, these efforts are all worthwhile; the Chinese government has not only ensured the health and interests of the Chinese people but also ensured stable economic growth in the region. We aim to study the relationship between Chinese government investment in health human capital and economic growth, using threshold effect models and instrumental variable methods to conduct empirical research on 26 provinces in Mainland China. The results show that, firstly, increasing government investment in health human capital can promote regional economic growth and exhibit a decreasing trend; secondly, there are differences in the influencing factors of government health investment on economic growth among different regions. From this, it can be seen that the government should formulate more scientific and reasonable government investment in health human capital policies based on factors, such as aging degree, residents’ health level, economic structure, and population size in different regions, to alleviate the pressure on government investment in health human capital and promote regional economic growth.
Reassessing the Climate Change Narrative
Authors: Lindzen Richard S. , Christy John R. 
Published: March 2024

AbstractWe note that the atmosphere has distinct tropical and extratropical regimes. The tropical regime is significantly dependent on the greenhouse effect and is characterized by temperatures that are largely horizontally homogenized. The extratropical regime is dominated by large scale unstable convective eddies that transport heat between the tropics and the poles (leaving the poles warmer than they otherwise would be) and serve to determine the temperature difference between the tropics and the poles. Changes in tropical temperature and in the tropics-to-pole temperature difference both contribute to changes in global mean temperature. It turns out that changes in global mean temperature associated with major climate change (i.e., the last glacial maximum and the warm period of the Eocene about 50 million years ago) were associated primarily with changes in the tropics-to-pole temperature differences. By contrast, changes in global mean temperature over the past 150 years or so are almost entirely associated with changes in tropical temperature. Thus, there is no intrinsic amplification associated with a change in the tropics-to-pole temperature difference. However, model simulations of climate behave differently from both observations and from each other. In particular, they all show more significant contributions for the tropics-to-pole temperature difference – sometimes much more significant. They also show excessive tropical warming.