bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perancangan Sistem Informasi Pemesanan Menu Berbasis Android
Authors: Niesa Chaeroen , Mutasar Mutasar , Hasanah Uswatul 
Published: March 2024

MC Coffe Bireuen merupakan suatu tempat yang dikunjungi pelanggan untuk berbelanja makanan dan minuman, bisnis restoran sudah begitu banyak di minati oleh masyarakat pada umumnya, karena selain memiliki omset yang bagus juga mudah berkembang. Kondisi di MC cafe saat ini masih menggunakan cara memesan secara manual dan pembebasan penggunaan akses internet oleh pelanggan. Hal tersebut menyulitkan pemilik cafe dalam pengeluaran biaya tagihan akses internet, di tambah dengan sistem pembayaran pun masih manual yang menyebabkan perhitungan cukup memakan waktu. maka dirancang sebuah website lokal dan sistem manajemen penggunaan akses internet yang mampu memberikan solusi dalam mengerjakan layanan pemesanan. Pada rancangan sistem aplikasi ini menyediakan menu pemesanan secara android agar memudahkan bagi pelanggan maupun pekerjanya dalam menangani pemesanan maupun pembayaran.
Kata Kunci : Cafe, Sistem Informasi, Web, Android, Codeigniter
Rancang Bangun Alat Monitoring Suhu Blood Bank Refrigerator Dengan Sistem Database
Authors: Soeparli Alian Jerly , Muhtar Muhtar , Ruhyana Lili , Gunawan Gunawan 
Published: March 2024

Blood Bank Refrigerator adalah peralatan yang digunakan sebagai pendingin. Biasanya alat ini digunakan untuk menyimpan darah, dan berbagai produk darah seperti plasma, trombosit, dan sel darah merah. Blood Bank Refrigerator dapat mempertahankan kualitas produk darah meskipun disimpan dalam waktu yang lama. Suhu yang tidak sesuai dapat membuat darah menggumpal atau pecah, sehingga tidak aman untuk diberikan kepada pasien. Masalah pada blood bank referigator yaitu tidak bisa dimonitoring, dan saat ini pemantauan suhu pada kulkas penyimpan darah masih dilakukan mandiri dengan mencatat manual.Berdasarkan uraian diatas, pada Tugas Akhir ini penulis akan membuat alat monitoring suhu blood bank referigator berbasis database. Penelitian ini menggunakan metode System Development Life Cycle (SDLC) adalah proses pembuatan dan pengubahan sistem serta model dan metodologi yang digunakan untuk mengembangkan sebuah sistem. Pada pengukuran suhu dilakukan dengan nilai 4°C yang ditampilan pada LCD dan database. Menggunakan waktu rata-rata 12 menit dan pengukuran setiap 2 menit pengujian sebanyak 6 kali dari 2 blood bank refrgator didapatkan rata-rata selisih kurang dari 0,2°C . Setelah dilakukan pengujian dan pendataan modul, dapat disimpulkan bahwa modul dan program berjalan dengan baik sesuai dengan perencanaan.
New possibilities of artificial intelligence in medicine: a narrative review
Authors: Litvin A. A. , Stoma I. O. , Sharshakova T. M. , Rumovskaya S. B. , Kyovalev A. A. 
Published: March 2024

The purpose of the narrative review is to provide a descriptive analysis of the emerging capabilities of artificial intelligence (AI) to improve the diagnosis, prevention and treatment of various diseases. The article discusses which modern AI tools can be used in clinical practice, healthcare organization and medical education. The paper considers various aspects of medical AI systems, which are mainly computer support systems for medical decision-making in the process of clinical work. Much attention is paid to the possibilities of generative AI in medicine. Potential applications of AI in clinical practice have been investigated, highlighting promising prospects for both practitioners and their patients. The limitations associated with the use of AI in various fields of medicine are described, and possible ways of solving them are suggested. The problems of information security and ethical constraints associated with the introduction of AI are outlined. The broad integration of AI into public health will enhance clinical and management decision support, speed up disease diagnosis, and improve the overall quality and accessibility of healthcare services.
Comparative evaluation of the biological activity of quercetin-like compounds
Authors: Tsymbal D. O. 
Published: March 2024

Objective. To determine the degree of manifestation of antioxidant, oncoprotective, anti-inflammatory properties of quercetin-like compounds of a number of flavonoids based on a comparative analysis of the complexing activity of oxygen-containing functional groups. Materials and methods. Analysis and systematization of literary data, a rationalistic method of modeling the properties of molecular systems. Results. The expediency of determining the structural identity of separate sections of molecules of various flavonoids for the subsequent determination of the degree of correlation of their biological properties is shown. Conclusion. Comparison of biological properties of substances of plant origin in combination with application of the latest extraction methods will help to accelerate drug development at the stage of obtaining a new active substance.
Unresolved issues in the use of imaging techniques in COVID-19-associated lesions of the stomach intestine
Authors: Yurkovskiy А. М. , Boika M. A. 
Published: March 2024

Objective. To systematize and analyze data on the use of imaging techniques in COVID-19-associated gastric and intestinal lesions. Materials and methods. An analysis of publications in PubMed, EMBASE and Web of Science systems was carried out in the period 2020-2023, describing the use of imaging techniques in patients with a confirmed diagnosis of COVID-19-associated gastrointestinal lesions. Results. The most frequent signs of COVID-19-associated gastric and intestinal lesions on abdominal imaging were identified, their incidence and approximate diagnostic significance were evaluated. Conclusion. The use of computed tomography and ultrasonography for the diagnosis of COVID-19-associated gastrointestinal lesions is hampered by the lack of clear ideas regarding the sensitivity, specificity, and prognostic value of the previously described radiologic signs of gastrointestinal lesions. In addition, there is no clear algorithm for the use of imaging methods in COVID-19-associated abdominal pain syndrome. The solution of these issues will optimize the use of imaging methods and reduce the time of diagnostic search.
Ultrasound predictors of outcome of traumatic brain injury
Authors: Markevich D. P. , Viktorovich N. E. , Denisenko T. V. 
Published: March 2024

Objective. To evaluate the possibility of ultrasound monitoring of optic nerve sheath diameter and blood flow velocity in cerebral arteries as predictors of craniocerebral trauma outcome. Materials and methods. 35 patients with traumatic brain injury (TBI) were produced ultrasound monitoring of the optic nerve sheath diameter (ONSD) and blood flow velocity (BFV) in the middle cerebral artery (AMC) before surgery and for 10 days after craniotomy. A comparative analysis of blood flow in the A MC and ONSD was carried out between groups of patients with a favorable (group 1) and unfavorable (group 2) outcome of TBI. Results. Between the groups of patients with different outcome`s TBI, significant differences were revealed in the diameter of the optic nerve sheaths at the preoperative period and in the diastolic blood flow velocity in the MCA on the 9th day after surgery. In group 1, the ONSD was 4.7 [4.5; 5.1] mm, and in group 2 – 5.6 [5.4; 6] mm, p=0.003. On the 9th day after surgery, BFV at diastole in group 1 was 43.9 [38.7; 49.4] cm/sec, in group 2 – 28.7 [24.8; 36.7] cm/sec, p = 0.001. For ONSD in the preoperative period as a predictor of unfavorable outcome of TBI AUC=0.83, Se=88.8%, Sp=61.2%. For diastolic BFV in the AMC on the 9th day after surgery – AUC = 0.84, Se=93%, Sp = 52 %. Conclusion. In patients with traumatic brain injury, ultrasound examination shows that the diameter of the optic membranes before surgery is ≥5.6 mm and the blood flow velocity in the middle cerebral artery in diastole ≤28.7 cm/sec can be considered as predictors of an unfavorable outcome of TBI.
Features of structural and geometric cardiac remodeling in patients with diabetes mellitus depending on chronic kidney disease stages
Authors: Vasilkova V. N. , Pchelin I. Yu. , Naumenava Ya. L. , Borovets Ya. A. , Yarets Yu. I. , Mokhort T. V. 
Published: March 2024

Objective. To study the features of structural and geometric cardiac remodeling in patients with diabetes mellitus (DM) depending on the stage of chronic kidney disease (CKD). Materials and methods. We examined 499 patients (127 men and 322 women) with type 1 DM (133 people) and type 2 DM (316 people) aged 62 [52;69] years. The comparison group consisted of 65 randomly selected volunteering individuals (54 women and 11 men) without disorders of carbohydrate metabolism and kidney damage aged 59 [46;66] years. The laboratory examination of the patients included the measurement of serum creatinine, eGFR according to the CKD-EPI equation. An echocardiographic investigation was performed to study structural and geometric heart parameters. Left ventricular hypertrophy (LVH) was diagnosed when the left ventricular myocardial mass index (LVMI) exceeded 115 g/m2 in men and 95 g/m2 in women. Results. LVH was detected in 57.7 % of patients with DM, while in the comparison group – in 35.4 %. The frequency of LVH increased with a decrease in eGFR and was diagnosed in 100 % of cases with CKD 5. In patients with DM, the left ventricular concentric remodeling significantly predominated (29.2%). Multiple linear regression analysis demonstrated the influence of age (ß=0.30, p=0.01) and serum creatinine (ß = 0.15, p < 0.0001) on the LVMI, independent of other factors, which confirms their independent pathogenetic significance. Conclusion. Thus, patients with DM regardless of the CKD stage have structural and functional changes in the LV myocardium. Regardless of the nitrogen-excretion function of the kidneys, the predominant pattern of LV remodeling is concentric. The study of the features of structural and functional restructuring of the left heart in patients with diabetes should be taken into account in determining the cardiovascular prognosis.
Comparative assessment of hemodynamic parameters during anesthesia in orthopedic and traumatological operations on the lower extremities in children
Authors: Rozin Yu. E. 
Published: March 2024

Objective. To conduct a comparative analysis of hemodynamic parameters during orthopedic and traumatological operations on the lower extremities in children performed under conditions of multicomponent balanced general and combined anesthesia. Materials and methods. A single-center prospective study. The present study included 60 children aged 6 to 17 years who underwent planned orthopedic and trauma surgery interventions on the lower extremities. Patients were divided into two groups depending on the method of anesthesia: Group 1 (n = 25) - multicomponent balanced general anesthesia, Group 2 (n = 35) - combined anesthesia (multicomponent balanced general anesthesia in combination with regional blocks of the sciatic and femoral nerves). To solve these problems, a comparative analysis of heart rate, systolic, diastolic and mean arterial blood pressure was carried out at seven stages of the study: 1st stage - initial, child on the operating table; 2nd stage - induction of anesthesia; 3rd stage - placement of the laryngeal mask; 4th stage - start of the operation; 5th stage - traumatic stage of the operation; 6th stage - completion of the operation; 7th stage - after removal of the laryngeal mask. Results. In all cases, the surgical interventions were successful. The study found that in the group of children who underwent multicomponent general anesthesia at the 4th (start of surgery), 5th (traumatic stage of surgery) and 6th (end of surgery) stages, heart rate (HR) was higher compared to the group of combined anesthesia. Systolic and mean arterial blood pressure during the traumatic phase of surgery were also higher in children undergoing multicomponent general anesthesia. The values of diastolic blood pressure did not differ between groups throughout the study with the exception of the 3rd stage (laryngeal mask placement) where lower values were observed in patients of the Group 1. Diastolic blood pressure values did not differ between groups throughout the study, with the exception of 3th stage (laryngeal mask placement), where lower values were noted in Group 1 patients. Conclusion. Combined methods of anesthesia based on the combination of multicomponent general anesthesia and conductive peripheral nerve blocks provide the greatest hemodynamic stability during orthopedic and traumatologic surgeries on the lower extremities in children.
The significance of light chronodestruction in the development of the embryotoxic effect in the experiment
Authors: Pashinskaya E. S. , Sobolevskaya I. S. , Pashinskaya A. K. , Ignateva I. V. , Pobyarzhin V. V. , Sobolevsky S. L. , Chicherova K. A. 
Published: March 2024

Objective. To assess the significance of light chronodestruction in the development of the embryotoxic effect in the experiment. Materials and methods. The experiment was conducted on 60 female rats of the Wistar line. To assess the significance of chronodestruction in the development of embryotoxic effect, the uterus was isolated in the experiment, in which the number of implantation sites, the total number of embryos, the number of live and dead embryos, and the number of resorptions were estimated. The number of corpus luteum in the harvested ovaries was estimated. In addition, the mean embryo weight (g) and mean craniocaudal size (mm) were recorded. Indicators of embryotoxic effects of light deprivation were determined by pre- and post-implantation death, which was calculated in accordance with methodological recommendations. Results. Exposure to light deprivation reduces the number of implantation sites as of 7th, 14th and 21st days by 1,5-1,8 times, the total number of embryos by 1,6-1,8 times, the number of living embryos by 2,2-9 times and increases the number of dead embryos as of 14th and 21st days by 4-5,5 times, the number of resorptions – 1,6-11 times. The average craniocaudal size (mm) of embryos in experimental animals was recorded below control values by 1,5 times, 1,3 and 3,7 times by 7th, 14th, 21st days respectively. In females exposed to light deprivation, there was a significant increase in pre-implantation mortality by 35-41,8 times and post-implantation mortality by 7,2-20,4 times compared to the control. Conclusion. Light deprivation may have a negative effect on pregnancy and fetal development in female rats, which is confirmed by an increase in pre- and post-implantation mortality.
Methods of intrinsic and probe fluorescence in assessment of the effect of therapeutic radiation doses <i>in vitro</i> on the albumin molecule
Authors: Puzan N. D. , Cheshik I. A. , Belyakovsky V. N. 
Published: March 2024

Objective. To study in vitro the effect of therapeutic doses of radiation on the albumin molecule using intrinsic and probe fluorescence methods. Materials and methods. In order to study radiation-induced changes in serum albumin during in vitro irradiation with therapeutic doses (2 Gy, 40 Gy and 70 Gy), the study was conducted in 2 directions: therapeutic doses of ionizing radiation irradiated a buffer, which was then used to prepare an albumin solution (pre-irradiation of the buffer); therapeutic doses of ionizing radiation irradiated an albumin buffer solution. The presence of structural and functional (conformational) changes in the albumin molecule was judged by changes in the values of intrinsic (λexc=280 nm) and probe (λexc=280nm, λexc=320 nm) fluorescence. Statistical processing of the obtained data was carried out using the program GraphPad Prism 6.0. Results. Irradiation with therapeutic doses of 2 Gy, 40 Gy and 70 Gy causes conformational changes (a statistically significant decrease in fluorescence intensity) in the albumin molecule, both during preliminary irradiation of the buffer solution used later for the preparation of albumin, and during irradiation of the buffer solution of albumin. Conclusions. Quantitative changes in the fluorescence intensity, both intrinsic and probe, differ under different modes of albumin irradiation.
Changes in energy metabolism of rat myocardium during exposure to ionizing radiation
Authors: Koval A. N. 
Published: March 2024

Objective. To study the effect of incorporated 137Cs on the energy metabolism of the myocardium of white rats. Materials and methods. The work was carried out on 8 male white rats divided into 2 experimental groups, which were fed products contaminated with 137Cs for 7 days. Polarography was used to study the rate of oxygen consumption by myocardial tissue preparations on endogenous substrates, with the addition of exogenous succinic and glutamic acids, and with the addition of an uncoupler of oxidative phosphorylation, 2,4-dinitrophenol.Results. An increase in the rate of respiration on endogenous substrates caused by the uncoupling of oxidative phosphorylation was noted. At the same time, no statistically significant change in the amount of endogenous substrates was found. Conclusion. The revealed violation of energy production in the myocardium of experimental animals is caused by the uncoupling of oxidative phosphorylation, and can be explained by a change in the operation of potassium channels, which can explain the development of cardiovascular pathology under the action of ionizing radiation.
Study of the sensitivity of methicillin-resistant <i>Staphylococcus aureus</i> to antibiotics and bacteriophage preparations
Authors: Lagun L. V. , Kulvinsky Ya. A. , Kulvinskaya N. A. 
Published: March 2024

Objective. To evaluate the sensitivity of methicillin-resistant Staphylococcus aureus strains to antibiotics and therapeutic and prophylactic preparations of bacteriophages. Materials and methods. The antibiotic sensitivity of strains of methicillin-resistant S.aureus was studied by the disco-diffusion method, the determination of the minimum inhibitory concentrations of vancomycin and linezolid by broth microdilution method, and ceftaroline by E-tests. The sensitivity of methicillin-resistant S.aureus to bacteriophage preparations was studied. Results. It has been established that linezolid and vancomycin are quite active drugs against methicillin-resistant S.aureus (MRSA), however, resistance to them begins to develop. MRSA resistance to fluoroquinolones and cefoxitin was the highest of all antibiotics tested; the results obtained with cefoxitin can be interpreted for other cephalosporins (except ceftaroline) and all penicillins. Only 67.9% of MRSA strains retained sensitivity to ceftaroline, but ceftaroline-resistant strains had low levels of minimal inhibitory concentration. The preparations of the bacteriophages “Sextaphage” and “Piobacteriophage Phagio” showed their lytic activity only in relation to 35.8% and 18.9% of MRSA isolates, respectively. Conclusion. Monitoring the development of antibiotic resistance in methicillin-resistant S.aureus is an important part of the strategy of rational antibiotic therapy for staphylococcal infections. Only taking into account the preliminary step-by-step determination of the phage sensitivity of the causative agent of the disease, bacteriophage preparations can be considered as a completely possible alternative to antibiotics for the treatment of purulent inflammatory diseases caused by MRSA.
Dynamics of morbidity and mortality from cancer in Gomel region: statistical analysis and forecast using ARIMA model up to 2030
Authors: Volchek V. S. , Sharshakova T. M. , Los’ D. M. 
Published: March 2024

Objective. To analyze the time series of morbidity and mortality from breast cancer, prostate cancer, colorectal cancer and cervical cancer in Gomel region for the period from 1982 to 2022 using ARIMA method and to make a prediction up to 2030. Materials and methods. We analyzed morbidity and mortality data from these cancers using statistical methods, including ARIMA modeling. Data on age at diagnosis, stage of disease, percentages of cancer detected at different stages, percentages of mortality and its dynamics after diagnosis were used. Results. On the basis of data analysis using ARIMA model, a model for predicting the incidence of cancer in the near future was developed. According to the forecast, it should be expected that there will be an increase in the incidence of breast, prostate, cervical and colorectal cancer until 2030, a decrease in the age of patients at first detection, a change in the pattern of detection at different stages and an increase in the percentage of disease detection in preventive examinations. Mortality from these types of cancer is projected to increase, with some changes in the average age of patientsof death indicators and stage dynamics. Conclusion. Predicting cancer incidence and mortality rates emphasizes the need for increased screening and early diagnosis of malignant neoplasms. This can improve earlier detection of the disease and increase the effectiveness of treatment, reducing overall cancer mortality.
Gender peculiarities of cortisol, testosterone and vitamin D blood levels in athletes
Authors: Brel Yu. I. , Medvedeva G. A. , Khaustava A. S. 
Published: March 2024

Objective. To assess the gender characteristics of the concentration of cortisol, testosterone and vitamin D in blood serum in athletes, and to analyze the correlations between vitamin D levels and the hormonal status of athletes. Materials and methods. 52 athletes (32 men and 20 women) were examined, their age was 17-23, their sports specialization was cyclic sports (kayaking) and acyclic sports (gymnastics, martial arts), and qualification – candidates for master of sports, masters of sports. Venous blood was taken in the morning on an empty stomach before training loads. Determination of total testosterone and cortisol concentration and assessment of vitamin D level by determination of its metabolite 25(OH)D (25-hydroxyvitamin D) in blood serum was performed by immunochemiluminescent method. Results. In male athletes with vitamin D deficiency, serum testosterone concentration and anabolic index were significantly lower (p = 0.0093 and p = 0.0015, respectively) compared to the same indices in the group of athletes with normal vitamin D content. Correlation analysis in male athletes revealed a positive correlation between serum 25(OH)D (25-hydroxyvitamin D) content and testosterone concentration (r = 0.36; p < 0.05), as well as between 25(OH)D content and anabolic index (r = 0.42; p < 0.05). The group of female athletes with vitamin D deficiency showed significantly lower serum testosterone concentration compared to athletes with normal vitamin D levels (p = 0.0112). No significant relationships were found between vitamin D levels and cortisol concentrations in both male and female athlete groups. Conclusion. The study results can be the evidence of modulation effect of vitamin D on testosterone levels in male athletes, indicating the importance of controlling and correcting vitamin D content in the dynamics of the training process.