bluuebunny/crossref_metadata_2025_split huggingface dataset:
Longitudinal analysis of 20 Years of external quality assurance schemes for PCR/NAAT-based bacterial genome detection in diagnostic testing
Authors: Kremser Marcel , Weiss Nathalie , Kaufmann-Stoeck Anne , Vierbaum Laura , Kappler Silke , Schellenberg Ingo , Hiergeist Andreas , Fingerle Volker , Baier Michael , Reischl Udo 
Published: March 2024

Background:Quality control (QC), quality assurance, and standardization are crucial for modern diagnostic testing in the field of medical microbiology. The need for efficient QC to ensure accurate laboratory results, treatment, and infection prevention has led to significant efforts in standardizing assay reagents and workflows. External quality assessment (EQA) schemes, like those offered by INSTAND, play a vital role in evaluating in-house and commercial routine diagnostic assays, regarded as mandatory by national and global guidelines. The recent impact of polymerase chain reaction/nucleic acid amplification technology (PCR/NAAT) assays in medical microbiology requires that high-performing assays be distinguished from inadequately performing ones, especially those made by inexperienced suppliers.Objectives:The study assesses the evolving diagnostic performance trends over 2 decades for the detection of EHEC/STEC, Borrelia (B.) burgdorferi, and MRSA/cMRSA. It explores the historical context of assay utilization, participant engagement, and rates of correct results in EQA schemes. The research seeks to identify patterns in assay preferences, participant proficiency, and the challenges encountered in detecting emerging variants or clinical strains.Results:The study highlights the decline in in-house PCR assay usage, the emergence of new diagnostic challenges, and educational aspects within EQA schemes. Specific examples, such as the inclusion, in certain EQA surveys, of EHEC strains carrying stx-2f or B. miyamotoi, highlight the role of EQAs in increasing awareness and diagnostic capabilities. Advancements in MRSA detection, especially through the adoption of commercial assays, demonstrate the impact that technology evolution has had on diagnostic performance.Conclusion:Achieving excellence in diagnostic molecular microbiology involves a multifaceted approach, including well-evaluated assays, careful instrumentation selection, and structured training programs. EQA schemes contribute significantly to this pursuit by providing insights into the evolving diagnostic landscape and identifying areas for improvement in the diagnostic workflow as well as in PCR/NAAT assay design.
Abnormalities of white matter network properties in middle-aged and elderly patients with functional constipation
Authors: Xueyan Hou , Qi Ai , Chunming Song , Yu Zhi , Wencai Weng 
Published: March 2024

PurposeTo explore white matter network topological properties changes in middle-aged and elderly patients with functional constipation (Functional Constipation, FC) by diffusion tensor imaging (DTI), and to evaluate the correlation between the abnormal changes and clinical data.Methods29 FC patients and 31 age- and sex-matched healthy controls (HC) were recruited. Magnetic resonance imaging and clinical data were collected. The white matter network changes in FC patients were analyzed using deterministic fiber tracking methods, graph theory algorithms, and partial correlation analysis with clinical data.ResultsThe nodal clustering coefficient and nodal local efficiency of FC patients in the right orbital inferior frontal gyrus, right medial superior frontal gyrus, right rectus muscle, right hippocampus, left paracentral lobule and left temporal pole, and the nodal clustering coefficient in right orbital superior frontal gyrus, left cuneus lobe and right superior occipital gyrus, the nodal local efficiency in the right medial and paracingulate gyrus, right precuneus and right dorsolateral superior frontal gyrus of FC patients are lower than that of HC. The nodal local efficiency and clustering coefficient of FC patients in left hippocampus, left amygdala, right parietal inferior limbic angular gyrus and right angular gyrus, the nodal local efficiency in the right fusiform gyrus, left supplementary motor cortex and the nodal efficiency in the left lateral temporal gyrus and right orbital middle frontal gyrus (ORBmid.R) of FC patients are higher than that of HC. The nodal efficiency of ORBmid.R in FC was positively correlated with the Patient Assessment of Constipation quality of life questionnaire (PAC-QoL).ConclusionMiddle-aged and elderly FC patients have differences in the nodal level properties in the limbic system, supplementary motor cortex, and default mode network brain regions, and the nodal efficiency of ORBmid.R was positively correlated with the PAC-QoL score, revealing that FC may be related to the abnormal processing of visceral sensorimotor in ORBmid.R and providing potential imaging diagnostic markers and therapeutic targets for middle-aged and elderly FC patients.
The effect of lexical triggers on Spanish-English code-switched judgment tasks
Authors: Koronkiewicz Bryan , Delgado Rodrigo 
Published: March 2024

IntroductionIt has been argued that certain words can “trigger” intrasentential code-switching. While some researchers suggest that cognates establish triggering at the lexical level, others have argued that words that lack direct translations are more natural stories switch. Yet to be tested experimentally is to what extent different types of lexical items influence the acceptability of mixed utterances.MethodsThe current study investigates this methodological consideration for code-switching research by having early US Spanish-English bilinguals (i.e., heritage speakers of Spanish) complete an acceptability judgment task with a 7-point Likert scale directly comparing cognates (e.g., sopa “soup”) and culturally specific items (e.g., pozole “traditional Mexican soup”) in otherwise identical grammatical switched sentences (N = 24).ResultsThe results showed that there was no significant effect of condition (p = 0.623) suggesting that cognates and language-specific items are equally acceptable in code-switched sentences. Indeed all conditions were rated on average above 6.DiscussionThese findings show that in this context, judgment tasks are not affected differently by these types of lexical items.
Re-imagining crisis care: experiences of delivering and receiving the Assured brief psychological intervention for people presenting to Emergency Departments with self-harm
Authors: Shah Neha , O’Keeffe Sally , Hayward Sam , Suzuki Mimi , McCabe Rose 
Published: March 2024

BackgroundRisk of suicide is increased immediately following emergency department (ED) attendance for self-harm. Evidence suggests that brief psychological interventions delivered in EDs are effective for self-harm. The Assured intervention comprises an enhanced biopsychosocial assessment in the ED, collaborative safety planning and three rapid solution focused follow-up sessions.AimWe addressed the following research questions: What were ED mental health liaison practitioners’ and patients’ experiences of the Assured intervention? What were the barriers and facilitators? What might the mechanisms be for improving experiences and outcomes?MethodsWe conducted a feasibility study of the Assured intervention in four EDs in Southeast England. Semi-structured interviews were conducted with 13 practitioners and 27 patients. Interviews were transcribed, coded line-by-line in Nvivo and thematically analysed using an inductive approach. Inter-rater reliability was calculated with a kappa coefficient of 0.744.
Validity evaluation of the Health Information Preferences Questionnaire among college students
Authors: Tang Kaiqi , Yuan Junfeng , Luo Lin 
Published: March 2024

ObjectiveThis study aims to explore the association between health information preferences and specific health behaviors and outcomes, such as preventive measures and chronic disease management among college students. It assesses how different levels of health information preference influence individuals’ utilization, perception, and self-efficacy within healthcare and health information contexts. Given the rising prevalence of non-communicable chronic diseases among younger populations in China, this research seeks to understand how tailored health information preferences can support effective health education and behavioral interventions. The development of the Health Information Preference Questionnaire (HIPQ) aims to bridge the existing gap in tools for assessing health information preferences among Chinese college students, with a focus on collecting validity evidence to confirm the HIPQ’s applicability in this group.MethodsThe study employed a mixed-methods approach, beginning with an initial item pool derived from a comprehensive review of existing research tools, literature, and expert inputs. An expert review panel conducted item evaluations, leading to item reduction for clarity and relevance. The validation process utilized two independent samples of college students, detailing the sample size (n = 446 for preliminary testing, n = 1,593 for validation) and characteristics (age, major, urban vs. rural background) to enhance the understanding of the study’s generalizability.ResultsThe HIPQ, comprising 25 items across five dimensions—prevention-oriented approaches, relationship with healthcare providers, self-efficacy in obtaining health information, perception of the importance of health information, and health information behavior—demonstrated excellent content validity (ICVI ranged from 0.72 to 0.86). Factor analysis confirmed significant loadings for each item across the anticipated factors, with fit indices (RMSEA = 0.065, CFI = 0.942) supporting good model fit. The HIPQ’s reliability was underscored by Cronbach’s alpha coefficients (&gt;0.8) for each subscale, with significant correlations across all subscales, indicating strong internal consistency and construct validity.ConclusionThe HIPQ proves to be a reliable and valid instrument for assessing health information preferences among Chinese college students, highlighting its potential for broader application in health education and intervention strategies. Recognizing the study’s focus on a specific demographic, future research should investigate the HIPQ’s adaptability and utility in broader populations and different cultural settings. The study’s limitations, including its concentrated demographic and context, invite further exploration into the HIPQ’s applicability across diverse groups. Additionally, potential future research directions could include longitudinal studies to assess the impact of tailored health information on actual health outcomes and behaviors.
A collaborative network trial to evaluate the effectiveness of implementation strategies to maximize adoption of a school-based healthy lunchbox program: a study protocol
Authors: Barnes Courtney , Jones Jannah , Wolfenden Luke , Robertson Katie , Seidler Anna Lene , Norman Jennifer , Budgen Pip , Mattingly Megan , Piliskic Carla , Moorhouse Lisa , Mozina Jennifer , Plaskett Jennifer , McDermott Sarah , Darney Sara , Vuong Cecilia , Douglass Nina , McDonnell Kara , Sutherland Rachel 
Published: March 2024

IntroductionAn important impediment to the large-scale adoption of evidence-based school nutrition interventions is the lack of evidence on effective strategies to implement them. This paper describes the protocol for a “Collaborative Network Trial” to support the simultaneous testing of different strategies undertaken by New South Wales Local Health Districts to facilitate the adoption of an effective school-based healthy lunchbox program (‘SWAP IT’). The primary objective of this study is to assess the effectiveness of different implementation strategies to increase school adoption of the SWAP across New South Wales Local Health Districts.MethodsWithin a Master Protocol framework, a collaborative network trial will be undertaken. Independent randomized controlled trials to test implementation strategies to increase school adoption of SWAP IT within primary schools in 10 different New South Wales Local Health Districts will occur. Schools will be randomly allocated to either the intervention or control condition. Schools allocated to the intervention group will receive a combination of implementation strategies. Across the 10 participating Local Health Districts, six broad strategies were developed and combinations of these strategies will be executed over a 6 month period. In six districts an active comparison group (containing one or more implementation strategies) was selected. The primary outcome of the trial will be adoption of SWAP IT, assessed via electronic registration records captured automatically following online school registration to the program. The primary outcome will be assessed using logistic regression analyses for each trial. Individual participant data component network meta-analysis, under a Bayesian framework, will be used to explore strategy-covariate interactions; to model additive main effects (separate effects for each component of an implementation strategy); two way interactions (synergistic/antagonistic effects of components), and full interactions.DiscussionThe study will provide rigorous evidence of the effects of a variety of implementation strategies, employed in different contexts, on the adoption of a school-based healthy lunchbox program at scale. Importantly, it will also provide evidence as to whether health service-centered, collaborative research models can rapidly generate new knowledge and yield health service improvements.Clinical trial registrationThis trial is registered prospectively with the Australian New Zealand Clinical Trials Registry (ACTRN12623000558628).
A surprising lack of consequences when constraining language
Authors: Vaughan-Johnston Thomas Ian , Nguyen Andrew , Jacobson Jill A. 
Published: March 2024

IntroductionLabels considered normatively appropriate for specific social identity groups change. Researchers have examined the effects of censorship and slur usage, but minimal research examines the psychological consequences of imposing new language constraints on people.MethodsAcross four samples of university students (Ntotal = 997), we sought participants' compliance in avoiding usage of numerous commonplace group labels while they wrote essays about obese people (Sample 1) or specific ethnic groups (Samples 2-4).ResultsWe observed consistently high compliance rates: participants either invented novel terminology to describe the group or avoided group labels entirely. We observed a substantial absence of task discomfort, attitudinal shifts regarding the group, or motivational shifts, according to Bayesian analyses. Nor did we detect negative effects of language constraint among people who saw themselves as opposed to censorship.DiscussionAlthough free speech and respectful language remain a multifaceted social debate, our findings show that university students are willing to follow even completely contrived language directives when describing social identity groups and to do so without substantial discomfort or backlash against those groups.
Reliability of Xsens inertial measurement unit in measuring trunk accelerations: a sex-based differences study during incremental treadmill running
Authors: Miqueleiz Unai , Aguado-Jimenez Roberto , Lecumberri Pablo , Garcia-Tabar Ibai , Gorostiaga Esteban M. 
Published: March 2024

IntroductionInertial measurement units (IMUs) are utilized to measure trunk acceleration variables related to both running performances and rehabilitation purposes. This study examined both the reliability and sex-based differences of these variables during an incremental treadmill running test.MethodsEighteen endurance runners performed a test–retest on different days, and 30 runners (15 females) were recruited to analyze sex-based differences. Mediolateral (ML) and vertical (VT) trunk displacement and root mean square (RMS) accelerations were analyzed at 9, 15, and 21 km·h−1.ResultsNo significant differences were found between test-retests [effect size (ES)&lt;0.50)]. Higher intraclass correlation coefficients (ICCs) were found in the trunk displacement (0.85-0.96) compared to the RMS-based variables (0.71–0.94). Male runners showed greater VT displacement (ES = 0.90–1.0), while female runners displayed greater ML displacement, RMS ML and anteroposterior (AP), and resultant euclidean scalar (RES) (ES = 0.83–1.9).DiscussionThe IMU was found reliable for the analysis of the studied trunk acceleration-based variables. This is the first study that reports different results concerning acceleration (RMS) and trunk displacement variables for a same axis in the analysis of sex-based differences.
A prospective and consecutive study assessing short-term clinical and radiographic outcomes of Chinese domestically manufactured 3D printing trabecular titanium acetabular cup for primary total hip arthroplasty: evaluation of 236 cases
Authors: Chen Guo , Wang Chen Yi , Ma Zou , Yi Hong Lin , Bi Na Meng , Zhu Wei Jiang , Han Jie , Lu Sha Li , Zhang Shang Shang , Shen Hai , Zhang Wu Hui , Zhang Peng , Si Yan 
Published: March 2024

PurposeWe prospectively evaluate the short-term clinical and radiographic outcomes of the only Chinese domestically produced trabecular titanium acetabular cup(3D ACT™ cup) in primary total hip arthroplasty (THA), aiming to provide evidence-based support for its clinical application.MethodsA total of 236 patients, who underwent primary THA using 3D ACT™ cup in the Department of Joint Surgery at our hospital between January 2017 and June 2019, were included in this study. General patient data, imaging information, functional scores, and complications were collected to evaluate the early clinical efficacy.ResultsAll patients were followed up for 33–52 months, with an average of (42.2 ± 9.2) months. At the last follow-up, the preoperative HHS score increased significantly from 43.7 ± 6.8 to 85.6 ± 9.3 points (P &lt; 0.01). Similarly, the preoperative WOMAC scores showed significant improvement from 59.2 ± 5.8 to 13.1 ± 3.5 points (P &lt; 0.01). 92.3% of the patients expressed satisfaction or high satisfaction with the clinical outcome. Furthermore, 87.7% of the acetabular cups were positioned within the Lewinnek safe zone, achieving successful reconstruction of the acetabular rotation center. The cup survival rate at the last follow-up was 100%.ConclusionsThe utilization of the only Chinese domestically manufactured 3D printing trabecular titanium acetabular cup in primary THA demonstrated favorable short-term clinical and radiographic outcomes. The acetabular cup exhibits excellent initial stability, high survival rate, and favorable osseointegration, leading to a significant enhancement in pain relief and functional improvement. In the future, larger sample sizes and multicenter prospective randomized controlled trials will be required to validate the long-term safety and effectiveness of this 3D ACT™ cup.
Impact of a Public Health Emergency on Behavior, Stress, Anxiety and Glycemic Control in Patients With Pancreas or Islet Transplantation for Type 1 Diabetes
Authors: Landstra Cyril P. , Ruissen Merel M. , Regeer Hannah , Nijhoff Michiel F. , Ballieux Bart E. P. B. , van der Boog Paul J. M. , de Vries Aiko P. J. , Huisman Sasja D. , de Koning Eelco J. P. 
Published: March 2024

A public health emergency such as the COVID-19 pandemic has behavioral, mental and physical implications in patients with type 1 diabetes (T1D). To what extent the presence of a transplant further increases this burden is not known. Therefore, we compared T1D patients with an islet or pancreas transplant (β-cell Tx; n = 51) to control T1D patients (n = 272). Fear of coronavirus infection was higher in those with β-cell Tx than without (Visual Analogue Scale 5.0 (3.0–7.0) vs. 3.0 (2.0–5.0), p = 0.004) and social isolation behavior was more stringent (45.8% vs. 14.0% reported not leaving the house, p &lt; 0.001). A previous β-cell Tx was the most important predictor of at-home isolation. Glycemic control worsened in patients with β-cell Tx, but improved in control patients (ΔHbA1c +1.67 ± 8.74 vs. −1.72 ± 6.15 mmol/mol, p = 0.006; ΔTime-In-Range during continuous glucose monitoring −4.5% (−6.0%–1.5%) vs. +3.0% (−2.0%–6.0%), p = 0.038). Fewer patients with β-cell Tx reported easier glycemic control during lockdown (10.4% vs. 22.6%, p = 0.015). All T1D patients, regardless of transplantation status, experienced stress (33.4%), anxiety (27.9%), decreased physical activity (42.0%), weight gain (40.5%), and increased insulin requirements (29.7%). In conclusion, T1D patients with β-cell Tx are increasingly affected by a viral pandemic lockdown with higher fear of infection, more stringent social isolation behavior and deterioration of glycemic control.This trial has been registered in the clinicaltrials.gov registry under identifying number NCT05977205 (URL: https://clinicaltrials.gov/study/NCT05977205).
ASUPAN ORAL INADEKUAT, PERUBAHAN NILAI LABORATORIUM, PERILAKU SALAH TENTANG MAKANAN PADA PASIEN CHRONIC KIDNEY DISEASE
Authors: Mahesa Dwipayani Ni Kadek , Fadhilah Zulfa Rizki , Isdiany Nitta 
Published: March 2024

Latar Belakang : Chronic Kidney Disease (CKD) atau Penyakit Ginjal Kronik (PGK) adalah penyakit yang menyerang ginjal dan kondisinya berangsur memburuk, menjadi kronis atau persisten dan berlangsung lama. Prevalensi kasus penyakit ginjal kronis di Indonesia menurut riset kesehatan dasar (Riskesdas) pada tahun 2018 adalah sebesar 0,38%. Hipertensi adalah salah satu faktor risiko yang sering ditemukan pada gagal ginjal. Peningkatan tekanan darah yang berlangsung lama pada arteriol dan glomeruli akan menyebabkan terjadinya sklerosis pada pembuluh darah. Kasus : Tn.U berusia 50 tahun mengalami masalah gizi asupan oral inadekuat, perubahan nilai ureum dan kreatinin dan perilaku salah tentang makanan selama rawat inap diagnosis medis pasien adalah CKD dan Hipertensi. Hasil dan Pembahasan : Pemberian diet awal rendah protein 0,6 lalu pada akhir perawatan menjadi TETP on HD 1,2 gr/kg BBI dalam bentuk lunak disesuaikan dengan kemampuan daya terima pasien dilakukan agar terjadi peningkatan asupan pasien. Syarat diet yang diberikan pada awal intervensi adalah energi 2047,5 kkal, protein 35,1 gr, lemak 68,25 gr, karbohidrat 323,5 gr. Hasil monitoring dan evaluasi menunjukkan selama pengamatan di hari ketiga asupan energy pasien mencapai 75%. Hasil ureum dan kreatinin juga mengalami penurunan, fisik/klinis menunjukkan sesak berkurang namun masih mengalami mual pasca hemodialisa. Kolaborasi dilakukan bersama dengan DPJP, ahli gizi ruangan, perawat, dan pramusaji. Selama intervensi juga diiberikan edukasi dan konseling terkait pengaturan makan pasien. Simpulan : intervensi yang diberikan dapat mengatasi sebagian masalah gizi pasien.
Identifikasi Potensi Produk Pariwisata Sebagai Dasar Perencanaan Paket Wisata di Desa Cacaban Kidul Kabupaten Purworejo, Provinsi Jawa Tengah
Authors: Kurniati Cucu , Josary P. Jessica Jocelyn , Sinaga Endang Komesty , Puksi Faisal , Andrianto Ronal 
Published: March 2024

Desa Cacaban Kidul which is located in the vicinity of the Borobudur Temple development area has potential in the tourism sector in three forms, including the form of natural tourism potential, cultural tourism, craft/creative tourism, as well as non-tourism potential such as agricultural and livestock product potential. This research hopes to be able to provide specific benefits for the welfare of the community through an effort to develop communitybased tourism through community empowerment in Desa Cacaban Kidul. In conducting the research, the potential of the tourism products and the components of tourism products in terms of attractions, amenities and accessibility in Desa Cacaban Kidul are identified and analyzed. The result of the study can serve as an opportunity for a creation of tour package as it serves some recommendation for Desa Cacaban Kidul so that they can be managed properly and optimally as an effort to develop sustainable tourism through a series of tourism activities packaged in a tour package.
Keywords: Tourism product, Tour Package Planning, Tourism Village