bluuebunny/crossref_metadata_2025_split huggingface dataset:
Data‐driven classification of left atrial morphology and its predictive impact on atrial fibrillation catheter ablation
Authors: Li Jiaju , Chen Ke , He Liu , Luo Fangyuan , Wang Xianqing , Hu Yucai , Zhao Jiangtao , Zhu Kui , Chen Xiaowei , Zhang Yuekun , Tao Hailong , Dong Jianzeng 
Published: March 2024

AbstractIntroductionVarious left atrial (LA) anatomical structures are correlated with postablative recurrence for atrial fibrillation (AF) patients. Comprehensively integrating anatomical structures, digitizing them, and implementing in‐depth analysis, which may supply new insights, are needed. Thus, we aim to establish an interpretable model to identify AF patients' phenotypes according to LA anatomical morphology, using machine learning techniques.Methods and ResultsFive hundred and nine AF patients underwent first ablation treatment in three centers were included and were followed‐up for postablative recurrent atrial arrhythmias. Data from 369 patients were regarded as training set, while data from another 140 patients, collected from different centers, were used as validation set. We manually measured 57 morphological parameters on enhanced computed tomography with three‐dimensional reconstruction technique and implemented unsupervised learning accordingly. Three morphological groups were identified, with distinct prognosis according to Kaplan−Meier estimator (p < .001). Multivariable Cox model revealed that morphological grouping were independent predictors of 1‐year recurrence (Group 1: HR = 3.00, 95% CI: 1.51−5.95, p = .002; Group 2: HR = 4.68, 95% CI: 2.40−9.11, p < .001; Group 3 as reference). Furthermore, external validation consistently demonstrated our findings.ConclusionsOur study illustrated the feasibility of employing unsupervised learning for the classification of LA morphology. By utilizing morphological grouping, we can effectively identify individuals at different risks of postablative recurrence and thereby assist in clinical decision‐making.
Perceptions of the effect of parental deportation on adult intimate relationships
Authors: Espinoza Sandra , Davis Sean , Seshadri Gita 
Published: March 2024

AbstractResearch has shown that children of undocumented Latinx parents in the United States are at greater risk for negative long‐term effects on their mental health and overall well‐being. Chief among these concerns are the negative effects of disrupted attachment processes, as deported parents are often taken from their families by force and required to parent from afar, if they can continue parenting at all. Despite the ubiquity of deported families, little is known about the effects of deportation on the attachment of left‐behind children and the subsequent potential disruptive effect of deportation on their adult relationships. This phenomenological study aims to understand how adults who have experienced parental deportation in their childhood describe the effects of that event on their adult intimate relationships. Themes of (1) ambiguous loss; (2) inability to trust others; (3) fear of separation from loved ones; and (4) shame emerged and are discussed considering existing literature on attachment theory, immigration, and the Latinx population. Treatment implications are also discussed.
Drivers and consequences of borrowers' voluntary privacy information disclosure—Evidence from a Chinese online consumer financing platform
Authors: Zhang Xiaodan , Fu Guoqun , Guo Maiju , Wang Zeng 
Published: March 2024

AbstractThis study explores the drivers and consequences of consumers' voluntary information disclosure in the context of online consumer financing. Using unique secondary data from a Chinese online consumer financing company, we uncover a non‐linear relationship between borrowers' credit ratings and the quantity of voluntary information disclosure, and an inverted U‐shaped relationship between the amount of information disclosure and loan default. Specifically, low‐credit borrowers who opt for more voluntary information disclosure manifest a higher likelihood of default than those who disclose less, suggesting a strategic inclination toward information disclosure. Finally, we identify that disclosing high‐cost information reduces loan default, whereas disclosing low‐cost information increases default. Our findings enrich the existing literature on consumer information disclosure by providing insights into the underlying motivation and highlighting the applicability of signaling theory and privacy calculus theory. This has practical implications for lenders, borrowers, and regulators in overcoming barriers in online lending.
The effect of emulgel preparation on the stability of Kojic acid in the topical anti‐hyperpigmentation products
Authors: Khadivi Yousef , Shakeri Saina , Arjmandmazidi Shiva , Shokri Javad , Monajjemzadeh Farnaz 
Published: February 2024

AbstractBackgroundThe emulgel, a novel drug delivery system, merges emulsion and gel, offering advantages like enhanced stability, precise control over drug release kinetics, and increased drug absorption compared to emulsions alone. Kojic acid (KA) demonstrates potent inhibition of the tyrosinase enzyme, a crucial player in the melanin synthesis pathway.AimsThe main objective of this experimental study is to formulate KA within an emulgel framework and assess its stability under various environmental conditions.MethodsOne percent of KA emulgel and 1% simple gel, serving as the control product, were supplemented with varying concentrations of sodium metabisulfite (SMBS) for its antioxidant properties. The formulations were segregated into four groups and subjected to diverse maintenance and stress conditions over a three‐month period. Monthly evaluations of physicochemical alterations were conducted, initially employing digital photography, followed by the extraction of KA and subsequent quantification of its concentration through high performance liquid chromatography (HPLC).ResultsThe best formulations for retaining KA among the prepared ones were the 0.25% SMBS KA emulgel and the 0.1% SMBS KA simple gel, capable of retaining 86% and 76% of the initial KA content under stress conditions, respectively (p < 0.0001).ConclusionsRegarding to this study, ideal storage condition for KA emulgel and simple gel is in the refrigerator temperatures. Moreover, optimal SMBS concentrations for stability enhancement are 0.25% for emulgel and 0.1% for the simple gel. A significant statistical difference was observed between refrigerated emulgel and simple gel in the retention of KA in the presence of optimum concentration of antioxidants (p < 0.0001).
Advanced practice nurses' evidence‐based healthcare competence and associated factors: A systematic review
Authors: Ylimäki Saija , Oikarinen Anne , Kääriäinen Maria , Pölkki Tarja , Mikkonen Kristina , Holopainen Arja , Kaakinen Pirjo , Kanste Outi , Meriläinen Merja , Jansson Miia , Immonen Kati , Tuomikoski Anna‐Maria 
Published: February 2024

AbstractBackgroundEvidence‐based healthcare (EBHC) enables consistent and effective healthcare that prioritises patient safety. The competencies of advanced practice nurses (APNs) are essential for implementing EBHC because their professional duties include promoting EBHC.AimTo identify, critically appraise, and synthesise the best available evidence concerning the EBHC competence of APNs and associated factors.DesignA systematic review.Data SourcesCINAHL, PubMed, Scopus, Medic, ProQuest, and MedNar.MethodsDatabases were searched for studies (until 19 September 2023) that examined the EBHC competence and associated factors of APNs were included. Quantitative studies published in English, Swedish and Finnish were included. We followed the JBI methodology for systematic review and performed a narrative synthesis.ResultsThe review included 12 quantitative studies, using 15 different instruments, and involved 3163 participants. The quality of the studies was fair. The APNs' EBHC competence areas were categorised into five segments according to the JBI EBHC model. The strongest areas of competencies were in global health as a goal, transferring and implementing evidence, while the weakest were generating and synthesising evidence. Evidence on factors influencing APNs' EBHC competencies was contradictory, but higher levels of education and the presence of an organisational research council may be positively associated with APNs' EBHC competencies.ConclusionThe development of EBHC competencies for APNs should prioritise evidence generation and synthesis. Elevating the education level of APNs and establishing a Research Council within the organisation can potentially enhance the EBHC competence of APNs.Implications for the ProfessionWe should consider weaknesses in EBHC competence when developing education and practical exercises for APNs. This approach will promote the development of APNs' EBHC competence and EBHC implementation in nursing practice.Registration, and Reporting ChecklistThe review was registered in PROSPERO (CRD42021226578), and reporting followed the PRISMA checklist.Patient/Public ContributionNone.
Giving birth after fertility‐sparing treatment for primary leiomyosarcoma of the fallopian tube
Authors: Wang Guo‐zeng , Xu Hua‐yun , Deng Shuang‐shuang , Gao Jin‐li , Cheng Jing‐xin 
Published: March 2024

AbstractPrimary leiomyosarcoma of the fallopian tube (PLFT) is an extremely rare gynecological malignancy that has only been described in case reports. Fertility‐sparing treatment for PLFT has not been reported previously. A 24‐year‐old nulligravida woman was diagnosed with stage IC1 PLFT in the right fallopian tube after experiencing right lower quadrant pain for 2 weeks. She underwent laparoscopic right salpingectomy to preserve fertility followed by adjuvant chemotherapy with gemcitabine/docetaxel. She subsequently became pregnant spontaneously, delivering a term baby 27 months after treatment. This appears to be the only report of the use of fertility‐preserving treatment for PLFT. The success of the treatment provides valuable information on the preservation of fertility in young women with PLFT.
The gains from changes in internal trade costs: A quantitative analysis of China
Authors: Che Zhilu , Che Jialu , Wang Sen 
Published: March 2024

AbstractWe study how internal trade costs affect the Chinese economy. Combining regional and industry data with a multiregional multisector general equilibrium model, we quantify the magnitude of total trade costs and institutional trade costs, and the impact of their changes on aggregate, regional, and sectoral total factor productivity, gross domestic product, and welfare. Using unique data, we estimate the sectoral trade elasticity of internal trade in 16 tradable sectors. We use our calibrated model to perform a variety of counterfactual exercises. We find that the welfare gains are negative for a 5% reduction in total trade costs and for the elimination of institutional trade costs, which can be attributed to inherent inefficiencies in the economy. However, as total trade costs decrease further, the positive welfare effect significantly exceeds the impact of inefficiency. The regional and sectoral effects of changes in trade costs show that the spatial structure of the economy, input‐output linkages, and local factors together determine the heterogeneity of sectoral and regional consequences. Finally, we infer the relative changes in China's internal trade costs from 2012 to 2017, and calculate their economic effects.
Comparative analysis of 326 chloroplast genomes in Chinese jujube (Ziziphus jujuba): Structural variations, horizontal gene transfer events, and evolutionary patterns impacting its domestication from wild jujube
Authors: Yang Meng , Zhang Shu‐Feng , Li Bin , Lan Yun‐Xin , Yang Yi‐Han , Liu Meng‐Jun 
Published: March 2024

AbstractJujube (Ziziphus jujuba Mill.), renowned for its nutritional value and health benefits, is believed to have originated in the middle and lower reaches of the Yellow River in China, where it underwent domestication from wild jujube. Nonetheless, the evolutionary trajectory and species differentiation between wild jujube and cultivated jujube still require further elucidation. The chloroplast genome (plastome), characterized by its relatively lower mutation rate compared to the nuclear genome, serves as an excellent model for evolutionary and comparative genomic research. In this study, we analyzed 326 nonredundant plastomes, encompassing 133 jujube cultivars and 193 wild jujube genotypes distributed throughout China. Noteworthy variations in the large single copy region primarily account for the size differences among these plastomes, impacting the evolution from wild jujube to cultivated varieties. Horizontal gene transfer (HGT) unveiled a unique chloroplast‐to‐nucleus transfer event, with transferred fragments predominantly influencing the evolution of the nuclear genome while leaving the plastome relatively unaffected. Population genetics analysis revealed two distinct evolutionary pathways from wild jujube to cultivated jujube: one driven by natural selection with minimal human interference, and the other resulting from human domestication and cultivation. Molecular dating, based on phylogenetic analysis, supported the likelihood that wild jujube and cultivated jujube fall within the same taxonomic category, Z. jujuba. In summary, our study comprehensively examined jujube plastome structures and HGT events, simultaneously contributing novel insights into the intricate processes that govern the evolution and domestication of jujube species.
Reduced plant species diversity and soil carbon and nitrogen contents driven by vegetation patchiness in alpine meadows
Authors: Xi Shougang , Hu Tinghua , Mou Xiaoming , Kou Xiaoxue , Wang Xianzhi , Yu Yingwen 
Published: February 2024

AbstractQuestionPatchiness of herbaceous species is a common feature of degraded alpine grasslands on the Qinghai–Tibet Plateau; however, the impact of this phenomenon on vegetation, soil seed bank (SSB), and soil carbon (C) and nitrogen (N) is largely unknown. We asked how different herbaceous patches affect above‐ground vegetation, the SSB and soil organic C (SOC) and total N (TN) contents in alpine meadows.LocationAn alpine meadow on the Qinghai–Tibetan Plateau, China.MethodsWe used field and greenhouse experiments to evaluate above‐ground vegetation parameters, the SSB composition, and SOC and TN contents of four commonly distributed herbaceous patches (Leymus secalinus, Kobresia humilis, Leontopodium nanum and Pedicularis kansuensis) and non‐patch vegetation (control).ResultsThere were significant differences in the species composition of above‐ground vegetation, with the plant species richness, Shannon–Wiener index, Simpson index, and Pielou evenness index reduced in the four patches compared to the control. In addition, patches had increased above‐ground biomass (AGB) and a lower below‐ground biomass to above‐ground biomass ratio (BGB:AGB); while the species diversity indices did not change considerably among the patches. The species composition of the SSB in the four patches differed from that in the control and the seed density increased markedly, but the species richness and diversity of the SSB remained unaltered. Moreover, the contents of SOC, total C, TN, microbial biomass C, and microbial biomass N in the four patches were markedly lower than in the control.ConclusionsThese findings suggest that patchiness of herbaceous species can alter the flora composition of alpine meadows and reduce plant species diversity, as well as the SOC and TN contents, which will adversely impact grassland biodiversity conservation and soil C sequestration, and then may intensify the degradation of alpine meadows on the Qinghai–Tibet Plateau.
Serum PRO‐C3 is useful for risk prediction and fibrosis assessment in MAFLD with chronic kidney disease in an Asian cohort
Authors: Tang Liang‐Jie , Sun Dan‐Qin , Song Sherlot Juan , Yip Terry Cheuk‐Fung , Wong Grace Lai‐Hung , Zhu Pei‐Wu , Chen Sui‐Dan , Karsdal Morten , Leeming Diana Julie , Jiang Pei , Wang Cong , Chen Qiang , Byrne Christopher D. , Targher Giovanni , Eslam Mohammed , George Jacob , Wong Vincent Wai‐Sun , Zheng Ming‐Hua 
Published: March 2024

AbstractBackgroundMetabolic dysfunction‐associated fatty liver disease (MAFLD) is an emerging risk factor for chronic kidney disease (CKD). N‐terminal propeptide of collagen type 3 (PRO‐C3) is a biomarker of advanced fibrosis in MAFLD and PRO‐C3 may be involved in renal fibrosis. We aimed to use PRO‐C3 measurements to generate a new algorithmic score to test the prediction of MAFLD with chronic kidney disease (MAFLD–CKD).MethodsA derivation and independent validation cohort of 750 and 129 Asian patients with biopsy‐confirmed MAFLD were included. Serum PRO‐C3 concentration was measured and regression analyses were performed to examine associations with MAFLD–CKD. A derivative algorithm for MAFLD–CKD risk prediction was evaluated with receiver operator characteristic (ROC) curve analysis.ResultsThe study included two Asian cohorts (n = 180 with MAFLD–CKD; mean‐eGFR: 94.93 mL/min/1.73 m2; median‐urinary albumin‐to‐creatinine ratio: 6.58 mg/mmol). PRO‐C3 was associated with the severity of MAFLD‐CKD and independently associated with MAFLD–CKD (adjusted odds ratio = 1.16, 95% confidence interval [CI]: 1.08–1.23, p < .001). A new non‐invasive score (termed PERIOD) including PRO‐C3 efficiently predicted MAFLD‐CKD (AUROC = .842, 95% CI: .805–.875). Accuracy, specificity and negative predictive values were 80.2%, 85.1% and 88.4%, respectively. In the validation cohort, the PERIOD score had good diagnostic performance (AUROC = .807, 95% CI: .691–.893) with similar results in all patient subgroups. In the MAFLD–CKD subgroup, the accuracy for identifying advanced fibrosis was further improved by combining the PRO‐C3‐based ADAPT with the Agile 3+ scores (AUROC = .90, 95% CI: .836–.964).ConclusionsThe PERIOD score is helpful for accurately predicting the risk of MAFLD–CKD. PRO‐C3 can also be used to assess liver fibrosis in people with MAFLD–CKD.
Thor's hammer: How warfare enables and disables nation formation
Authors: Hutchinson John 
Published: February 2024

AbstractScholars have neglected at a theoretical level the structuring role of warfare in the rise of nations and states. I argue that war‐making has been a constitutive force in the emergence and persistence of many national identities in four ways. First, wars can act as ‘turning points’ for good or ill to become national mythomoteurs. Second, they can create enduring popular we–they stereotypes against significant others. Third, they can generate a gemeinschaft of national sacrifice that anchors the nation after a return to peace. Finally, the outcomes of wars can legitimate ruling establishments or mobilise peoples against them. However, warfare can also disable nation formation. I shall focus on the impact of imperial wars on Eurasian borderland populations. While generating nationalism in these regions, such wars create shatter zones, marked by ethnic diversity and conflict that frustrate the formation of stable national communities.
BRAFV600E mutation mediates invasive and growth features in ameloblastoma
Authors: Zhang Chen‐Xi , Zhang Lin‐Zhou , Lin Hao , Man Qi‐Wen , Liu Bing 
Published: March 2024

AbstractObjectivesAmeloblastoma (AM), a locally aggressive tumor with extensive growth capacity, causes significant damage to the jaw and affects facial appearance. Although the high prevalence of BRAF V600E mutation in AM is known, its specific impacts on patients with AM remain unclear. Thus, the present study investigated the role of BRAF V600E mutation, thereby focusing on its impact on AM invasion and growth.Materials and MethodsImmunohistochemical analysis was used to compare BRAF V600E, MMP2, MMP9, and Ki‐67 expressions in AM (n = 49), normal oral mucosa (NOM) (n = 10), and odontogenic keratocyst (OKC) (n = 15) tissues. AM was further classified according to the presence or absence of BRAF V600E. The relationship between BRAF V600E and invasion as well as growth was evaluated. In addition, correlation analysis was performed using immunohistochemistry and confirmed via double‐labeling immunofluorescence. Finally, comparative analyses using mass spectrometry, immunohistochemistry, and immunofluorescence were performed to explore and identify underlying mechanisms.ResultsAM exhibited a higher incidence of BRAF V600E mutation than NOM and OKC. BRAF V600E expression was positively correlated with the invasion‐associated proteins MMP2 and MMP9 and the growth‐related protein Ki‐67. Proteomic data revealed that BRAF V600E primarily activates the MAPK signaling pathway in AM, particularly driving the phosphorylation of extracellular signal‐regulated kinase 1/2 (ERK1/2).ConclusionsIn summary, the findings suggested that the BRAF V600E mutation enhances the invasion and growth abilities of AM via the MAPK/ERK signaling pathway. Thus, targeting BRAF V600E or the MAPK/ERK pathway may be a potential AM therapy.
Beyond peaks and troughs: Multiplexed performance monitoring signals in the EEG
Authors: Ullsperger Markus 
Published: February 2024

AbstractWith the discovery of event‐related potentials elicited by errors more than 30 years ago, a new avenue of research on performance monitoring, cognitive control, and decision making emerged. Since then, the field has developed and expanded fulminantly. After a brief overview on the EEG correlates of performance monitoring, this article reviews recent advancements based on single‐trial analyses using independent component analysis, multiple regression, and multivariate pattern classification. Given the close interconnection between performance monitoring and reinforcement learning, computational modeling and model‐based EEG analyses have made a particularly strong impact. The reviewed findings demonstrate that error‐ and feedback‐related EEG dynamics represent variables reflecting how performance‐monitoring signals are weighted and transformed into an adaptation signal that guides future decisions and actions. The model‐based single‐trial analysis approach goes far beyond conventional peak‐and‐trough analyses of event‐related potentials and enables testing mechanistic theories of performance monitoring, cognitive control, and decision making.
“Hurdles” or “lubricants”: Petty corruption and Chinese migrants in Africa
Authors: Wang Jinpu 
Published: March 2024

AbstractDrawing on ethnographic fieldwork in Ghana and China between 2016 and 2022, this paper provides a sociological analysis of how new Chinese migrants in Ghana, and more generally in Sub‐Saharan Africa, navigate their social and economic integration into the host society by dealing with petty corruption in everyday life. This article examines how similarities and discrepancies in corruption norms contribute to “cultural matching” and cultural conflicts in Sino‐African encounters, as well as the coping strategies and social‐cultural techniques the migrants develop to navigate their relationship with local bureaucracy. My findings demonstrate that for migrants within the Global South, corruption in the sending and receiving regions is likely to be rooted in different politico‐economic structures and cultural grounds. Conflicting understandings of corruption can pose challenges to migrants' initial adaptation in the host society. However, as the migrants develop a proper “cultural toolkit,” engagement in corruption and rent‐seeking activities may provide a “cultural matching” interface that facilitates the rapid integration of new migrants into the local market and society. This study provides new insights into our understanding of bureaucracy in international migration, corruption, and migration settlement, as well as the sociocultural negotiation of corruption codes and norms in cross‐cultural encounters.