bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proximal Femoral Structure and the Prediction of Hip Fracture in Men: A Large Prospective Study Using QCT
Authors: Black Dennis M , Bouxsein Mary L , Marshall Lynn M , Cummings Steven R , Lang Thomas F , Cauley Jane A , Ensrud Kristine E , Nielson Carrie M , Orwoll Eric S 
Published: March 2008

Abstract
The structure of the femoral neck contributes to hip strength, but the relationship of specific structural features of the hip to hip fracture risk is unclear. The objective of this study is to determine the contribution of structural features and volumetric density of both trabecular and cortical bone in the proximal femur to the prediction of hip fracture in older men. Baseline QCT scans of the hip were obtained in 3347 men ≥65 yr of age enrolled in the Osteoporotic Fractures in Men Study (MrOS). All men were followed prospectively for an average of 5.5 yr. Areal BMD (aBMD) by DXA was also assessed. We determined the associations between QCT-derived measures of femoral neck structure, volumetric bone density, and hip fracture risk. Forty-two men sustained incident hip fractures during follow-up: an overall rate of 2.3/1000 person-years. Multivariable analyses showed that, among the QCT-derived measures, lower percent cortical volume (hazard ratio [HR] per SD decrease: 3.2; 95% CI: 2.2–4.6), smaller minimal cross-sectional area (HR: 1.6; 95% CI: 1.2–2.1), and lower trabecular BMD (HR: 1.7; 95% CI: 1.2–2.4) were independently related to increased hip fracture risk. Femoral neck areal BMD was also strongly related to hip fracture risk (HR: 4.1; 95% CI: 2.7–6.4). In multivariable models, percent cortical volume and minimum cross-sectional area remained significant predictors of hip fracture risk after adjustment for areal BMD, but overall prediction was not improved by adding QCT parameters to DXA. Specific structural features of the proximal femur were related to an increased risk of hip fracture. Whereas overall hip fracture prediction was not improved relative to aBMD, by adding QCT parameters, these results yield useful information concerning the causation of hip fracture, the evaluation of hip fracture risk, and potential targets for therapeutic intervention.
Genetic Variation in the Patterns of Skeletal Progenitor Cell Differentiation and Progression During Endochondral Bone Formation Affects the Rate of Fracture Healing
Authors: Jepsen Karl J , Price Christopher , Silkman Lee J , Nicholls Fred H , Nasser Phillip , Hu Bin , Hadi Nicole , Alapatt Michael , Stapleton Stephanie N , Kakar Sanjeev , Einhorn Thomas A , Gerstenfeld Louis C 
Published: March 2008

Abstract
These studies examined how genetic differences that regulate architectural and bone material properties would be expressed during fracture healing and determine whether any of these features would affect rates of healing as defined by regain of strength. Controlled fractures were generated in three inbred strains of mice: A/J, C57Bl/6J (B6), and C3H/HeJ (C3H). Both the A/J and B6 strains showed faster healing than the C3H strain based on regains in strength and stiffness. Strain-specific architectural features such as moment of inertia, cross-sectional area, and cortical thickness were all recapitulated during the development of the callus tissues. None of these traits were directly relatable to rates of fracture healing. However, rates of healing were related to variations in the temporal patterns of chondrogenic and osteogenic lineage development. The B6 strain expressed the highest percentage of cartilage gene products and had the longest period of chondrocyte maturation and hypertrophy. The slowest healing strain (C3H) had the shortest period of chondrogenic development and earliest initiation of osteogenic development. Although the A/J strain showed an almost identical pattern of chondrogenic development as the C3H strain, A/J initiated osteogenic development several days later than C3H during fracture healing. Long bone growth plates at 28 days after birth showed similar strain-specific variation in cartilage tissue development as seen in fracture healing. Thus, the B6 strain had the largest growth plate heights, cell numbers per column, and the largest cell size, whereas the C3H columns were the shortest, had the smallest number of cells per column, and showed the smallest cell sizes. These results show that (1) different strains of mice express variations of skeletal stem cell lineage differentiation and (2) that these variations affect the rate of fracture healing.
Exogenous PTH and Endogenous 1,25-Dihydroxyvitamin D Are Complementary in Inducing an Anabolic Effect on Bone
Authors: Samadfam Rana , Xia Qingwen , Miao Dengshun , Hendy Geoffrey N , Goltzman David 
Published: March 2008

Abstract
PTH and 1,25(OH)2D each exert dual anabolic and catabolic skeletal effects. We assessed the potential interaction of PTH and 1,25(OH)2D in promoting skeletal anabolism by comparing the capacity of exogenous, intermittently injected PTH(1-34) to produce bone accrual in mice homozygous for the 1α(OH)ase-null allele [1α(OH)ase−/− mice] and in wildtype mice. In initial studies, 3-mo-old wildtype mice were either injected once daily (40 μg/kg) or infused continuously (120 μg/kg/d) with PTH(1–34) for up to 1 mo. Infused PTH reduced BMD, increased the bone resorption marker TRACP-5b, and raised serum calcium but did not increase serum 1,25(OH)2D. Injected PTH increased serum 1,25(OH)2D and BMD, raised the bone formation marker osteocalcin more than did infused PTH, and did not produce sustained hypercalcemia as did PTH infusion. In subsequent studies, 3-mo-old 1α(OH)ase−/− mice, raised on a rescue diet, and wildtype littermates were injected with PTH(1–34) (40 μg/kg) either once daily or three times daily for 1 mo. In 1α(OH)ase−/− mice, baseline bone volume (BV/TV) and bone formation (BFR/BS) were lower than in wildtype mice. PTH administered intermittently increased BV/TV and BFR/BS in a dose-dependent manner, but the increases were always less than in wildtype mice. These studies show that exogenous PTH administered continuously resorbs bone without raising endogenous 1,25(OH)2D. Intermittently administered PTH can increase bone accrual in the absence of 1,25(OH)2D, but 1,25(OH)2D complements this PTH action. An increase in endogenous 1,25(OH)2D may therefore facilitate an optimal skeletal anabolic response to PTH and may be relevant to the development of improved therapeutics for enhancing skeletal anabolism.
Fracture Risk in Type 2 Diabetes: Update of a Population-Based Study
Authors: Melton L Joseph , Leibson Cynthia L , Achenbach Sara J , Therneau Terry M , Khosla Sundeep 
Published: March 2008

AbstractWe found no significant excess of fractures among Rochester, MN, residents with diabetes mellitus initially recognized in 1950–1969, but more recent studies elsewhere have documented an apparent increase in hip fracture risk. To explore potential explanations for any increase in fractures, we performed an historical cohort study among 1964 Rochester residents who first met glycemic criteria for diabetes in 1970–1994 (mean age, 61.7 ± 14.0 yr; 51% men). Fracture risk was estimated by standardized incidence ratios (SIRs), and risk factors were evaluated in Andersen-Gill time-to-fracture regression models. In 23,236 person-years of follow-up, 700 diabetic residents experienced 1369 fractures documented by medical record review. Overall fracture risk was elevated (SIR, 1.3; 95% CI, 1.2–1.4), but hip fractures were increased only in follow-up beyond 10 yr (SIR, 1.5; 95% CI, 1.1–1.9). As expected, fracture risk factors included age, prior fracture, secondary osteoporosis, and corticosteroid use, whereas higher physical activity and body mass index were protective. Additionally, fractures were increased among patients with neuropathy (hazard ratio [HR], 1.3; 95% CI, 1.1–1.6) and those on insulin (HR, 1.3; 95% CI, 1.1–1.5); risk was reduced among users of biquanides (HR, 0.7; 95% CI, 0.6–0.96), and no significant influence on fracture risk was seen with sulfonylurea or thiazolidinedione use. Thus, contrary to our earlier study, the risk of fractures overall (and hip fractures specifically) was increased among Rochester residents with diabetes, but there was no evidence that the rise was caused by greater levels of obesity or newer treatments for diabetes.
Miniature Compact Tension Specimens for Upper Shelf Fracture Toughness Measurements on RPV Steels
Authors: Lucon Enrico , Scibetta Marc 
Published: March 2008

Abstract
Miniature compact tension, MC(T), specimens (thickness B = 4.15 mm) have been recently investigated at SCK⋅CEN for measuring the fracture toughness of steels under fully ductile conditions (upper shelf regime). The first results of this assessment, made by comparison with results obtained from 1TC(T) samples of various RPV steels with quite different toughness properties, have been described in a previous paper by the same authors. It was observed that, although a systematic and significant underestimation of both critical toughness values and crack propagation resistance was observed for the MC(T) samples with respect to the bigger specimens, it is possible to establish an empirical correlation between the two geometries which allows deriving acceptable estimates of the material’s critical toughness. In this work, further investigations are presented, related to: (1) the behavior of MC(T) and 1TC(T) specimens in the crack tip blunting phase; (2) the role of work hardening in decreasing the tearing resistance of MC(T) specimens; and (3) the use of alternative parameters (crack-tip opening displacement, crack-tip opening angle, Ernst’s modified J-integral JM). Evidence is also presented which could justify a revision of the specimen measuring capacity (Jmax) in the current ASTM Standard E1820-05, which appears too severe and could be relaxed. Further work will include validating on irradiated materials the empirical correlations established between 1TC(T) and MC(T) test results.
The multiple personalities of water conservation
Authors: Samani Z. , Skaggs R. K. 
Published: March 2008

“Water conservation” means different things to different people and the principles of depletion and diversion are often confounded and misconstrued, particularly when the different perceptions of the value of water and units of analysis are involved. Many public policies and public and private investments have been implemented in the name of conserving water, particularly in irrigated agriculture. Unfortunately, many of these policies and investments cannot make additional water available to new users owing to the nature of closed basin hydrology. The assumption that farmers are low-efficiency irrigators is used to justify transfer of income and wealth to agricultural water users and others through direct investments and cost sharing programs. Instead, these programs serve to sustain and increase consumptive use of water in agriculture and disrupt the existing hydrologic balance. In arid climates, where deficit irrigation is practiced, conventional water conservation measures such as drip irrigation often result in increased depletion at the individual farm level and less water available for other users.
This paper discusses water conservation misconceptions, particularly those related to irrigated agriculture in the arid southwestern United States. Deficit irrigation is a common practice throughout the southwest, the region is experiencing rapid population growth and naturally limited water supplies have been exacerbated by current drought conditions. In this paper, the water conservation impacts of drip irrigation, irrigation scheduling and canal lining are discussed in the context of the hydrological assumptions that are used to promote these technologies. The potential of drip irrigation, irrigation scheduling and canal lining to sustain and increase crop evapotranspiration in deficit irrigation environments is illustrated.
Given hydrologic conditions, the authors conclude that accurate basin-wide accounting of water use, including equitable distribution based on existing legal entitlements would significantly contribute to water conservation efforts.
5-Lipoxygenase, but Not 12/15-Lipoxygenase, Contributes to Degeneration of Retinal Capillaries in a Mouse Model of Diabetic Retinopathy
Authors: Gubitosi-Klug Rose A. , Talahalli Ramaprasad , Du Yunpeng , Nadler Jerry L. , Kern Timothy S. 
Published: March 2008

OBJECTIVE—Lipoxygenases are regulators of chronic inflamation and oxidative stress generation. We evaluated the role of 5- and 12-lipoxygenases in the development of diabetic retinopathy.RESEARCH DESIGN AND METHODS—Wild-type mice, 5-lipoxygenase–deficient mice, and 12/15-lipoxygenase–deficient mice were assessed 1) after 9 months of diabetes for retinal histopathology and leukotriene receptor expression and 2) after 3 months of diabetes for leukostasis and retinal superoxide generation.RESULTS—Diabetic wild-type mice developed the expected degeneration of retinal capillaries and pericytes and increases in both leukostasis and superoxide production (P &lt; 0.006). We found no evidence of diabetes-induced degeneration of retinal ganglion cells in these animals. The vascular histopathology was significantly inhibited in 5-lipoxygenase–deficient mice, but not in 12/15-lipoxygenase–deficient mice. Retinas from diabetic 5-lipoxygenase–deficient mice also had significantly less leukostasis, superoxide production, and nuclear factor-κB (NF-κB) expression (all P &lt; 0.006), whereas retinas from diabetic 12/15-lipoxygenase–deficient mice had significantly less leukostasis (P &lt; 0.005) but not superoxide production or NF- κB expression. Retinas from diabetic wild-type mice were enriched with receptors for the 5-lipoxygenase metabolite leukotriene B4. Diabetes-induced histological and biochemical alterations were significantly reduced in 5-lipoxygenase–deficient mice, but not 12/15-lipoxygenase–deficient mice.CONCLUSIONS—5-Lipoxygenase represents a novel pathway for therapeutic intervention of diabetic retinopathy.
A Rare Mutation in ABCC8/SUR1 Leading to Altered ATP-Sensitive K+ Channel Activity and β-Cell Glucose Sensing Is Associated With Type 2 Diabetes in Adults
Authors: Tarasov Andrei I. , Nicolson Tamara J. , Riveline Jean-Pierre , Taneja Tarvinder K. , Baldwin Stephen A. , Baldwin Jocelyn M. , Charpentier Guillaume , Gautier Jean-François , Froguel Philippe , Vaxillaire Martine , Rutter Guy A. 
Published: March 2008

OBJECTIVE— ATP-sensitive K+ channels (KATP channels) link glucose metabolism to the electrical activity of the pancreatic β-cell to regulate insulin secretion. Mutations in either the Kir6.2 or sulfonylurea receptor (SUR) 1 subunit of the channel have previously been shown to cause neonatal diabetes. We describe here an activating mutation in the ABCC8 gene, encoding SUR1, that is associated with the development of type 2 diabetes only in adults.
RESEARCH DESIGN AND METHODS— Recombinant KATP channel subunits were expressed using pIRES2-based vectors in human embryonic kidney (HEK) 293 or INS1(832/13) cells and the subcellular distribution of c-myc–tagged SUR1 channels analyzed by confocal microscopy. KATP channel activity was measured in inside-out patches and plasma membrane potential in perforated whole-cell patches. Cytoplasmic [Ca2+] was imaged using Fura-Red.
RESULTS— A mutation in ABCC8/SUR1, leading to a Y356C substitution in the seventh membrane-spanning α-helix, was observed in a patient diagnosed with hyperglycemia at age 39 years and in two adult offspring with impaired insulin secretion. Single KATP channels incorporating SUR1-Y356C displayed lower sensitivity to MgATP (IC50 = 24 and 95 μmol/l for wild-type and mutant channels, respectively). Similar effects were observed in the absence of Mg2+, suggesting an allosteric effect via associated Kir6.2 subunits. Overexpression of SUR1-Y356C in INS1(832/13) cells impaired glucose-induced cell depolarization and increased in intracellular free Ca2+ concentration, albeit more weakly than neonatal diabetes–associated SUR1 mutants.
CONCLUSIONS— An ABCC8/SUR1 mutation with relatively minor effects on KATP channel activity and β-cell glucose sensing causes diabetes in adulthood. These data suggest a close correlation between altered SUR1 properties and clinical phenotype.
Removal of reactive dye brilliant red HE-3B from aqueous solutions by hydrolyzed polyacrylonitrile fibres: equilibrium and kinetics modelling
Authors: Bilba Doina , Suteu Daniela , Malutan Theodor 
Published: March 2008

Abstract
A cheap and efficient fibrous hydrolyzed polyacrylonitrile (HPAN) sorbent was obtained by alkaline hydrolysis of Romanian polyacrylonitrile fibres. Scanning electronic microscopy and infrared spectroscopy were used to characterize the hydrolyzed product and to confirm its functionalization. The adsorptive potential of the proposed sorbent for reactive dye Brilliant Red HE-3B removal from aqueous solutions of pH=2 was examined by the batch technique as a function of dye concentration, temperature solution and contact time. The Freundlich, Langmuir and Dubinin-Radushkevich adsorption models were applied to describe equilibrium sorption data and to determine the corresponding isotherm constants. The thermodynamic parameters ΔG, ΔH and ΔS were also determined; the values obtained show that sorption of reactive dye on HPAN fibres is a spontaneous, endothermic and entropy-driven process. The kinetics of sorption of the reactive dye were analyzed using pseudo-first order and pseudo-second order kinetic models. The kinetic data fitted well to pseudo-second order kinetics, indicating the chemisorption of reactive dye onto the fibrous sorbent. The sorption mechanism of the dye onto hydrolyzed fibres was confirmed by FTIR spectroscopy. The dye-loaded HPAN sorbent can be regenerated by treatment with 0.1M NaOH and the regenerated sorbent may be reused in several adsorption-desorption cycles. The results of this study provided evidence that the HPAN fibres are effective for removing reactive dye Brilliant Red HE-3B from aqueous effluents.
Electrochemical preparation and in situ characterization of poly(3-methylpyrrole) and poly(3-methylpyrrole-cyclodextrin) films on gold electrodes
Authors: Arjomandi Jalal , Holze Rudolf 
Published: March 2008

Abstract
A Electrosynthesis of conducting poly(3-methylpyrrole) (P3MPy) and poly(3-methylpyrrole-2,6-dimethyl-β-cyclodextrin) (poly(3MPy-β-DMCD)) films on a gold electrode in acetonitrile electrolyte solution containing lithium perchlorate has been carried out by potential cycling. Products were characterized with cyclic voltammetry CV, in situ UV-Vis spectroscopy, and in situ resistance measurements. Electrosynthesis of poly(3MPy-β-DMCD) started with a (1:1) (3MPy-β-DMCD) supramolecular cyclodextrin CD complex of 3-methylpyrrole characterized with proton NMR spectroscopy. The oxidation peak of poly(3MPy-β-DMCD) in CVs is shifted to more positive values than P3MPy. In situ resistance measurements show that the resistance of poly(3MPy-β-DMCD) is higher than of P3MPy by approximately an order of magnitude. Minimum resistance can be observed for P3MPy and poly(3MPy-β-DMCD) at 0.40 E Ag/AgClE Ag/AgClIn situ UV-Vis spectroelectrochemical data for both films prepared potentiodynamically by cycling the potential in the range −0.20 E Ag/AgCl
Evolution of the polarization of electromagnetic waves in weakly anisotropic inhomogeneous media — a comparison of quasi-isotropic approximations of the geometrical optics method and the Stokes vector formalism
Authors: Kravtsov Yury , Bieg Bohdan 
Published: March 2008

Abstract
The main methods describing polarization of electromagnetic waves in weakly anisotropic inhomogeneous media are reviewed: the quasi-isotropic approximation (QIA) of geometrical optics method that deals with coupled equations for electromagnetic field components, and the Stokes vector formalism (SVF), dealing with Stokes vector components, which are quadratic in electromagnetic field intensity. The equation for the Stokes vector evolution is shown to be derived directly from QIA, whereas the inverse cannot be true. Derivation of SVF from QIA establishes a deep unity of these two approaches, which happen to be equivalent up to total phase. It is pointed out that in contrast to QIA, the Stokes vector cannot be applied for a polarization analysis of the superposition of coherent electromagnetic beams. Additionally, the ability of QIA to describe a normal modes conversion in inhomogeneous media is emphasized.
Dynamic rotational characteristics of actinides on empirical approach
Authors: Kaczmarczyk Maria , Korejwo Andrzej 
Published: March 2008

Abstract
In the paper calculation of the moments of inertia for nuclei from the region 87 ≤ Z ≤ 100 and 130 ≤ N ≤ 156 was made in dependence on the angular momentum of their rotational states. The experimental values of the moments of inertia were calculated for rotational energy of the classic rotor in its quantum form, with the use of a simple formula. The moment of inertia term appearing in the formula was treated as a variable. The calculations were carried out on the basis of experimental data for the energies of the rotational levels for 51 bands built on ground states for even-even nuclei and for nuclei with odd mass number A. In addition, 30 rotational bands built on excited states were also analysed in the investigated region in case of even-even nuclei. For many bands and nuclei the considered dependence of the moment of inertia on angular momentum has been found in the analytical form by fitting polynomials to the experimental data. It turned out that obtained results for the moments of inertia made it possible to describe the energies of rotational levels with a relative deviation not greater or only slightly greater than 1%. In general, in the case of 12 bands of ground level the maximum relative deviation of obtained level energies is smaller than 1%.
Recurrence of retroperitoneal fibrosis with pancreatic involvement — the importance of imaging methods
Authors: Djerassi Regina , Krupev Martin , Nikolova Milena , Naumov Nikolai , Marianovski Valeri , Elenkov Chavdar , Postadjian Arman 
Published: March 2008

Abstract
Retroperitoneal fibrosis (RPF) is a rare disease associated with the development of chronic inflammation and fibrogenesis in the retroperitoneal space. The disease usually manifests with acute or acute over chronic renal failure and/or urosepsis. Pancreatic involvement in RPF is rare but has been described in the literature. The diagnosis of RPF is made mainly by imaging methods. Abdominal echography scan reveals the presence of an obstruction with or without inflammation; computed tomography and magnetic resonance imaging show the type and the spreading of fibrosis. Here, we report a 50-year-old female patient diagnosed with RPF during operative intervention in 2003. Initial treatment with corticosteroids and tamoxifen lead to remission. In 2007, late recurrence was observed, with tumor-like lesions over the upper, posterior, and anterior surfaces of the pancreas, spreading to intraperitoneal structures and more pronounced on the left side. Abdominal echography on day 30 showed that corticosteroid treatment lead to a decrease in the tumor-like lesions.