bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic impact and predictors of persistent renal dysfunction in acute kidney injury after percutaneous coronary intervention for acute myocardial infarction
Authors: Nakamura Takuya , Watanabe Makoto , Sugiura Junichi , Kyodo Atsushi , Nobuta Saki , Nogi Kazutaka , Nakada Yasuki , Ishihara Satomi , Hashimoto Yukihiro , Nakagawa Hitoshi , Ueda Tomoya , Seno Ayako , Nishida Taku , Onoue Kenji , Hikoso Shungo 
Published: March 2024

AbstractThis study aimed to evaluate the prognostic impact and predictors of persistent renal dysfunction in acute kidney injury (AKI) after an emergency percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI). A total of 877 patients who underwent emergency PCI for AMI were examined. AKI was defined as serum creatinine (SCr) ≥ 0.3 mg/dL or ≥ 50% from baseline within 48 h after PCI. Persistent AKI was defined as residual impairment of SCr ≥ 0.3 mg/dL or ≥ 50% from baseline 1 month after the procedure. The primary outcome was the composite endpoints of death, myocardial infarction, hospitalization for heart failure, stroke, and dialysis. AKI and persistent AKI were observed in 82 (9.4%) and 25 (2.9%) patients, respectively. Multivariate Cox proportional hazards analysis demonstrated that persistent AKI, but not transient AKI, was an independent predictor of primary outcome (hazard ratio, 4.99; 95% confidence interval, 2.30–10.8; P < 0.001). Age > 75 years, left ventricular ejection fraction < 40%, a high maximum creatinine phosphokinase MB level, and bleeding after PCI were independently associated with persistent AKI. Persistent AKI was independently associated with worse clinical outcomes in patients who underwent emergency PCI for AMI. Advanced age, poor cardiac function, large myocardial necrosis, and bleeding were predictors of persistent AKI.
Dual-tasking modulates movement speed but not value-based choices during walking
Authors: Grießbach Eric , Raßbach Philipp , Herbort Oliver , Cañal-Bruland Rouwen 
Published: March 2024

AbstractValue-based decision-making often occurs in multitasking scenarios relying on both cognitive and motor processes. Yet, laboratory experiments often isolate these processes, thereby neglecting potential interactions. This isolated approach reveals a dichotomy: the cognitive process by which reward influences decision-making is capacity-limited, whereas the influence of motor cost is free of such constraints. If true, dual-tasking should predominantly impair reward processing but not affect the impact of motor costs. To test this hypothesis, we designed a decision-making task in which participants made choices to walk toward targets for rewards while navigating past an obstacle. The motor cost to reach these rewards varied in real-time. Participants either solely performed the decision-making task, or additionally performed a secondary pitch-recall task. Results revealed that while both reward and motor costs influenced decision-making, the secondary task did not affect these factors. Instead, dual-tasking slowed down participants’ walking, thereby reducing the overall reward rate. Hence, contrary to the prediction that the added cognitive demand would affect the weighing of reward or motor cost differentially, these processes seem to be maintained at the expense of slowing down the motor system. This slowdown may be indicative of interference at the locomotor level, thereby underpinning motor-cognitive interactions during decision-making.
Plasma extracellular vesicle microRNAs reflecting the therapeutic effect of the CBP/β-catenin inhibitor PRI-724 in patients with liver cirrhosis
Authors: Yoshida Mayu , Matsuzaki Juntaro , Fujita Koji , Kimura Masamichi , Umezu Tomohiro , Tokuda Noi , Yamaguchi Tomoko , Kuroda Masahiko , Ochiya Takahiro , Saito Yoshimasa , Kimura Kiminori 
Published: March 2024

AbstractThere is an unmet need for antifibrotic therapies to prevent the progression of liver cirrhosis. Previously, we conducted an exploratory trial to assess the safety and antifibrotic efficacy of PRI-724, a selective CBP/β-catenin inhibitor, in patients with liver cirrhosis. PRI-724 was well tolerated and exerted a potential antifibrotic effect. Here, we investigated whether the profiles of circulating microRNAs packaged in extracellular vesicles (EV-miRNAs) are associated with responses to liver fibrosis treatments. Eighteen patients who received PRI-724 for 12 weeks in a phase 1/2a study were classified as responders (n = 10) or non-responders (n = 8) based on changes in liver stiffness. Plasma samples were obtained before and after PRI-724 administration and the levels of EV-miRNAs were analyzed. Three miRNAs (miR-6510-5p, miR-6772-5p, and miR-4261) were identified as predictors of response or non-response to PRI-724, and the levels of three other miRNAs (miR-939-3p, miR-887-3p, and miR-7112-5p) correlated with the efficacy of treatment. Expression of miR-887-3p was detected in hepatocytes and was decreased significantly in liver tissue following PRI-724 treatment. In addition, transfection of a miR-887-3p mimic activated hepatic stellate cells. Thus, decreases in the miR-887-3p level in blood may reflect recovery from liver fibroses in patients with liver cirrhosis treated with PRI-724, although further validation studies are warranted to confirm this.
Excavation method optimization and mechanical responses investigating of a shallow buried super large section tunnels: a case study in Zhejiang
Authors: Chen Yunteng , Geng Xiaoliang , Li Jianjun , Zhang Mingfeng , Zhu Chengfeng , Cai Mingcheng , Zhao Wenlin , Zhou Xin , Wang Tianzuo 
Published: March 2024

AbstractThe construction of super large section (SLS) shallow buried tunnels involves challenges related to their large span, high flat rate, and complex construction process. Selecting an appropriate excavation method is crucial for ensuring stability, controlling costs, and managing the construction timeline. This study focuses on the selection of excavation methods and the mechanical responses of SLS tunnels in different types of surrounding rock. The research is based on the Yangjiashan tunnel project in Zhejiang Province, China, which is a four-line highway tunnel with a span of 21.3 m. Three sequential excavation methods were proposed and simulated using the three-dimensional finite difference method: the “upper first and lower later” side drift (SD) method, the central diaphragm method, and the top heading and bench (HB) method. The mechanical response characteristics of tunnel construction under these methods were investigated, including rock deformation, rock pressure, and the internal forces acting on the primary support. By comparing the performance of the three construction methods in rock masses of Grades III to V, the study aimed to determine the optimal construction method for SLS tunnels considering factors such as safety, cost, and schedule. Field tests were conducted to evaluate the effectiveness of the optimized construction scheme. The results of the field monitoring indicated that the “upper first and lower later” SD method in Grade V rock mass and the HB method in Grade III to IV rock mass are feasible and cost-effective under certain conditions. The research findings provide valuable insights for the design and construction of SLS tunnels in complex conditions, serving as a reference for engineers and project managers.
Differential connectivity of the posterior piriform cortex in Parkinson’s disease and postviral olfactory dysfunction: an fMRI study
Authors: Georgiopoulos Charalampos , Buechner Martha Antonia , Falkenburger Bjoern , Engström Maria , Hummel Thomas , Haehner Antje 
Published: March 2024

AbstractOlfactory dysfunction is a common feature of both postviral upper respiratory tract infections (PV) and idiopathic Parkinson’s disease (PD). Our aim was to investigate potential differences in the connectivity of the posterior piriform cortex, a major component of the olfactory cortex, between PV and PD patients. Fifteen healthy controls (median age 66 years, 9 men), 15 PV (median age 63 years, 7 men) and 14 PD patients (median age 70 years, 9 men) were examined with task-based olfactory fMRI, including two odors: peach and fish. fMRI data were analyzed with the co-activation pattern (CAP) toolbox, which allows a dynamic temporal assessment of posterior piriform cortex (PPC) connectivity. CAP analysis revealed 2 distinct brain networks interacting with the PPC. The first network included regions related to emotion recognition and attention, such as the anterior cingulate and the middle frontal gyri. The occurrences of this network were significantly fewer in PD patients compared to healthy controls (p = 0.023), with no significant differences among PV patients and the other groups. The second network revealed a dissociation between the olfactory cortex (piriform and entorhinal cortices), the anterior cingulate gyrus and the middle frontal gyri. This second network was significantly more active during the latter part of the stimulation, across all groups, possibly due to habituation. Our study shows how the PPC interacts with areas that regulate higher order processing and how this network is substantially affected in PD. Our findings also suggest that olfactory habituation is independent of disease.
New measurements reveal a large contribution of nitrogenous molecules to ambient organic aerosol
Authors: Yu Xu , Li Qianfeng , Liao Kezheng , Li Yumin , Wang Xinming , Zhou Yang , Liang Yongmei , Yu Jian Zhen 
Published: March 2024

AbstractNitrogen is a significant element that constitutes ambient organic aerosol. Individual N-containing organic molecules are known to have both natural and anthropogenic sources and implicated in a wide-ranging health and environmental effects. Yet, unlike carbon (C), the total quantity of aerosol organic nitrogen (ON) remains largely unquantified, hindering a quantitative understanding of their major sources and impacts. Here, aerosol ON is quantitatively surveyed in hundreds of aerosol filter samples collected from sites of varying urban influence in China using our recently developed method that permits simple, and yet sensitive, simultaneous detection of inorganic and organic nitrogen. Annual average ON concentration was in the range of 0.4–1.4 μg N m−3, representing 17–31% of aerosol total nitrogen. Monte Carlo simulations constrained by paired ON and OC measurements suggest N-containing organic molecules contributed typically 37–50%, with a 95% confidence interval of [12%, 94%], to ambient organic aerosols. Source apportionment analysis reveals that biomass burning and secondary formation are dominant ON sources, accounting for 21–24% and ~ 30% of ON, respectively. Primary biological aerosol is also a significant source of ON (7–18%), with its contribution more prominent in non-urban atmospheres. The results provide the quantitative data for the extent of presence of organic nitrogenous aerosol and the origin of their major sources. Such data, we anticipate, would bring forth a breakthrough in our ability to describe and model organic aerosols and to assess their environmental impacts, such as atmospheric nitrogen nutrient inputs to ecosystems.
Acoustic monitoring reveals a diel rhythm of an arctic seabird colony (little auk, Alle alle)
Authors: Podolskiy Evgeny A. , Ogawa Monica , Thiebot Jean-Baptiste , Johansen Kasper L. , Mosbech Anders 
Published: March 2024

AbstractThe child-like question of why birds sing in the morning is difficult to answer, especially in polar regions. There, in summer animals live without the time constraints of daylight, and little is known about the rhythmicity of their routines. Moreover, in situ monitoring of animal behavior in remote areas is challenging and rare. Here, we use audio data from Greenland to show that a colony of a key Arctic-breeding seabird, the little auk (Alle alle), erupts with acoustic excitement at night in August, under the midnight sun. We demonstrate that the acoustic activity cycle is consistent with previous direct observations of the feeding and attendance patterns of the little auk. We interpret this pattern as reflecting their foraging activities, but further investigation on fledging and predators is needed. The study demonstrates that acoustic monitoring is a promising alternative to otherwise demanding manual observations of bird colonies in remote Arctic areas.
Ca2+ oscillation in vascular smooth muscle cells control myogenic spontaneous vasomotion and counteract post-ischemic no-reflow
Authors: Li Jinze , Zhang Yiyi , Zhang Dongdong , Wang Wentao , Xie Huiqi , Ruan Jiayu , Jin Yuxiao , Li Tingbo , Li Xuzhao , Zhao Bingrui , Zhang Xiaoxuan , Lin Jiayi , Shi Hongjun , Jia Jie-Min 
Published: March 2024

AbstractIschemic stroke produces the highest adult disability. Despite successful recanalization, no-reflow, or the futile restoration of the cerebral perfusion after ischemia, is a major cause of brain lesion expansion. However, the vascular mechanism underlying this hypoperfusion is largely unknown, and no approach is available to actively promote optimal reperfusion to treat no-reflow. Here, by combining two-photon laser scanning microscopy (2PLSM) and a mouse middle cerebral arteriolar occlusion (MCAO) model, we find myogenic vasomotion deficits correlated with post-ischemic cerebral circulation interruptions and no-reflow. Transient occlusion-induced transient loss of mitochondrial membrane potential (ΔΨm) permanently impairs mitochondria-endoplasmic reticulum (ER) contacts and abolish Ca2+ oscillation in smooth muscle cells (SMCs), the driving force of myogenic spontaneous vasomotion. Furthermore, tethering mitochondria and ER by specific overexpression of ME-Linker in SMCs restores cytosolic Ca2+ homeostasis, remotivates myogenic spontaneous vasomotion, achieves optimal reperfusion, and ameliorates neurological injury. Collectively, the maintaining of arteriolar myogenic vasomotion and mitochondria-ER contacts in SMCs, are of critical importance in preventing post-ischemic no-reflow.
A systematic pan-cancer study on deep learning-based prediction of multi-omic biomarkers from routine pathology images
Authors: Arslan Salim , Schmidt Julian , Bass Cher , Mehrotra Debapriya , Geraldes Andre , Singhal Shikha , Hense Julius , Li Xiusi , Raharja-Liu Pandu , Maiques Oscar , Kather Jakob Nikolas , Pandya Pahini 
Published: March 2024

Abstract
Background
The objective of this comprehensive pan-cancer study is to evaluate the potential of deep learning (DL) for molecular profiling of multi-omic biomarkers directly from hematoxylin and eosin (H&E)-stained whole slide images.

Methods
A total of 12,093 DL models predicting 4031 multi-omic biomarkers across 32 cancer types were trained and validated. The study included a broad range of genetic, transcriptomic, and proteomic biomarkers, as well as established prognostic markers, molecular subtypes, and clinical outcomes.

Results
Here we show that 50% of the models achieve an area under the curve (AUC) of 0.644 or higher. The observed AUC for 25% of the models is at least 0.719 and exceeds 0.834 for the top 5%. Molecular profiling with image-based histomorphological features is generally considered feasible for most of the investigated biomarkers and across different cancer types. The performance appears to be independent of tumor purity, sample size, and class ratio (prevalence), suggesting a degree of inherent predictability in histomorphology.

Conclusions
The results demonstrate that DL holds promise to predict a wide range of biomarkers across the omics spectrum using only H&E-stained histological slides of solid tumors. This paves the way for accelerating diagnosis and developing more precise treatments for cancer patients.
Improved measurement of disease progression in people living with early Parkinson’s disease using digital health technologies
Authors: Czech Matthew D. , Badley Darryl , Yang Liuqing , Shen Jie , Crouthamel Michelle , Kangarloo Tairmae , Dorsey E. Ray , Adams Jamie L. , Cosman Josh D. 
Published: March 2024

Abstract
Background
Digital health technologies show promise for improving the measurement of Parkinson’s disease in clinical research and trials. However, it is not clear whether digital measures demonstrate enhanced sensitivity to disease progression compared to traditional measurement approaches.

Methods
To this end, we develop a wearable sensor-based digital algorithm for deriving features of upper and lower-body bradykinesia and evaluate the sensitivity of digital measures to 1-year longitudinal progression using data from the WATCH-PD study, a multicenter, observational digital assessment study in participants with early, untreated Parkinson’s disease. In total, 82 early, untreated Parkinson’s disease participants and 50 age-matched controls were recruited and took part in a variety of motor tasks over the course of a 12-month period while wearing body-worn inertial sensors. We establish clinical validity of sensor-based digital measures by investigating convergent validity with appropriate clinical constructs, known groups validity by distinguishing patients from healthy volunteers, and test-retest reliability by comparing measurements between visits.

Results
We demonstrate clinical validity of the digital measures, and importantly, superior sensitivity of digital measures for distinguishing 1-year longitudinal change in early-stage PD relative to corresponding clinical constructs.

Conclusions
Our results demonstrate the potential of digital health technologies to enhance sensitivity to disease progression relative to existing measurement standards and may constitute the basis for use as drug development tools in clinical research.
Cellular energy regulates mRNA degradation in a codon-specific manner
Authors: Tomaz da Silva Pedro , Zhang Yujie , Theodorakis Evangelos , Martens Laura D , Yépez Vicente A , Pelechano Vicent , Gagneur Julien 
Published: March 2024

AbstractCodon optimality is a major determinant of mRNA translation and degradation rates. However, whether and through which mechanisms its effects are regulated remains poorly understood. Here we show that codon optimality associates with up to 2-fold change in mRNA stability variations between human tissues, and that its effect is attenuated in tissues with high energy metabolism and amplifies with age. Mathematical modeling and perturbation data through oxygen deprivation and ATP synthesis inhibition reveal that cellular energy variations non-uniformly alter the effect of codon usage. This new mode of codon effect regulation, independent of tRNA regulation, provides a fundamental mechanistic link between cellular energy metabolism and eukaryotic gene expression.
The Validity and Reliability of the Turkish Version of Preschool Hearing Environments and Reflection on Quality of Life Questionnaire
Authors: Kırseven Sinem , Tahir Emel , Yaşar Özlem Cangökçe 
Published: March 2024

Purpose:
The purpose of this study was to assess preschool children's hearing-related quality of life and to introduce the scale, originally titled “Preschool Hearing Environments and Reflections on Quality of Life Questionnaire” (Preschool HEAR-QL), to the literature through Turkish adaption, validity, and reliability analyses.

Method:

Our study included 210 children aged 2–6 years: 110 with hearing loss (56 cochlear implant users and 54 hearing aid users) and 100 with normal hearing. Demographic data were collected and then the Preschool HEAR-QL, which was translated into Turkish, was administered twice at 15-day intervals. Confirmatory factor analysis was used to determine whether the factor structure found in the original scale development study was confirmed in our sample (construct validity). Cronbach's alpha, intraclass correlation scores, and the test–retest method were used to assess the scale's reliability as the findings were analyzed using paired samples
t
tests.

Results:

The children with hearing loss had lower scores than their normal-hearing peers, and the difference was significant in the subdomains of behavior and attention, hearing environments, and communication. The subscale of the Preschool Period Listening Environments and their Reflections on Quality of Life Scale consists of 23 items, and Cronbach's alpha value was found as 0.922 in the first application and 0.926 in the second application (high reliability). In the model established for validity analysis, χ
2
/
df
= 2.156, root-mean-square error of approximation = 0.074, standard root-mean-square residual = 0.078, goodness-of-fit index = 0.830, adjusted goodness-of-fit index = 0.789, comparative fit index = 0.895, and Tucker–Lewis index = 0.881 (good model fit). In terms of test–retest reliability, the correlation between the two measurements was 0.837, and there was no statistical difference between the test–retest scores (
p
= .15).

Conclusion:
The Turkish version of the Preschool HEAR-QL scale was proven to be a valid and reliable scale for assessing the hearing-related quality of life of children aged 2–6 years.

Supplemental Material:

https://doi.org/10.23641/asha.25236949
A case study on the barriers towards achieving sustainable smart city for Abu Dhabi
Authors: Ajaj Rahaf , Buniya Mohanad Kamil , Wuni Ibrahim Yahaya , Yousif Omar Sedeeq 
Published: March 2024

AbstractDeveloping sustainable smart cities (SSCs) is crucial to modern urban growth, as recognised in various international policies and literature. With Abu Dhabi as a focus, this research aims to identify and evaluate the primary obstacles that hinder the creation of intelligent and sustainable cities. By categorising and ranking these barriers, the study seeks to prioritise the most significant hindrances to smart city development. The research analysed 31 barriers, classified them into six groups, and examined them through existing literature. Semi‐structured interviews with stakeholders responsible for implementing the SSC strategy provided additional valuable insights. The study used the Partial Least Squares Path Modelling method to prioritise the selected barriers. The results showed that the most significant barriers to SSC development were in the Economic category, followed by Technology, Governance, Social, Legal, Ethical, and Environmental barriers. This research provides valuable insights for policymakers and the Abu Dhabi government to eliminate obstacles that hinder SSC development initiatives.