bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diseño y validación de un instrumento para medir el nivel de participación de los trabajadores en un Sistema de Gestión de Seguridad y Salud en el Trabajo
Authors: Gutierrez Pablo , Alegre-Quintana Jesus , Agustini-Paredes Liliana 
Published: February 2025

Introducción: La seguridad y salud en el trabajo se puede ver afectada por diversos factores internos y externos. Entre ellos, el más importante es el factor humano. El objetivo de este estudio fue diseñar y validar un cuestionario para medir el nivel de participación de los trabajadores en los sistemas de gestión de seguridad y salud en el trabajo.
Método: Para el diseño del cuestionario se consultó la normativa peruana y las recomendaciones de instituciones internacionales, entre otros. Para la validación cualitativa se empleó el juicio de expertos, utilizando el coeficiente de validez de contenido (CVC). Para la validación cuantitativa se aplicó el análisis de fiabilidad mediante el coeficiente alpha de Cronbach, análisis de correlación de las preguntas y el análisis de la validez de constructo mediante el análisis factorial exploratorio y confirmatorio.
Resultados: Se diseñó un cuestionario de 25 preguntas cuyo CVC fue 0.94. La validación cuantitativa se realizó en la Facultad de Ingeniería Industrial de la Universidad Nacional Mayor de San Marcos, obteniéndose como resultado del análisis de fiabilidad, análisis del constructo y análisis factorial exploratorio la eliminación de 5 preguntas. El análisis factorial confirmatorio mostró que las 20 preguntas restantes tienen cargas factoriales superiores a 0.50, y el nuevo análisis de fiabilidad presenta un coeficiente alfa de Cronbach de 0.949.
Conclusiones: Disponer de un cuestionario validado permitirá contribuir a determinar el grado de participación en seguridad y salud en el trabajo en las empresas, y evaluar la necesidad y impacto de las mejoras que sean implementadas.
Gamma-aminobutiric acid-B receptor antibody-related limbic encephalitis due to small cell lung carcinoma: Two case reports
Authors: Myrou Athena D , Spilioti Martha G , Tsolaki Anthoula C , Frontistis Antonis N , Savopoulos Christos G 
Published: February 2025

BACKGROUND
Paraneoplastic limbic encephalitis (LE) is an inflammatory condition that affects the limbic system, cerebellum, and peripheral nervous system. It causes a range of symptoms including short-term memory loss, impaired cognitive function, behavioral and psychological disorders, and seizures. Paraneoplastic LE can occur when an immune response is activated due to antibodies targeting gamma-aminobutyric acid (GABA) B receptor (GABABR) interacting with antigens on tumor cells and the nervous system, resulting in tumors primarily as small cell lung carcinoma (SCLC).
CASE SUMMARY
We discuss two cases of GABABR antibody-related LE resulting from SCLC. The patients’ symptoms were managed with immunotherapy but ended in premature death due to chemotherapy-related complications.
CONCLUSION
Paraneoplastic syndrome is a notable cause of LE. Early intravenous immunoglobulin therapy may lead to temporary remission.
Total versus robotic-assisted unicompartmental knee replacement (TRAKER) for medial compartment osteorthritis: a randomized controlled trial
Authors: Clement Nick D. , Scott Chloe E. H. , Macpherson Gavin J. , Simpson Philip M. , Leitch Gillian , Patton James T. 
Published: February 2025

AimsUnicompartmental knee arthroplasty (UKA) is associated with an accelerated recovery, improved functional outcomes, and retention of anatomical knee kinematics when compared to manual total knee arthroplasty (mTKA). UKA is not universally employed by all surgeons as there is a higher revision risk when compared to mTKA. Robotic arm-assisted (ra) UKA enables the surgeon to position the prosthesis more accurately when compared to manual UKA, and is associated with improved functional outcomes and a lower early revision risk. Non-randomized data suggests that, when compared to mTKA, raUKA has a clinically meaningful greater functional benefit. This protocol describes a randomized controlled trial that aims to evaluate the clinical and cost-effectiveness of raUKA compared to mTKA for individuals with isolated medial compartment osteoarthritis (OA).MethodsThe total versus robotic-assisted unicompartmental knee arthroplasty (TRAKER) trial is a patient- and assessor-blinded, pragmatic parallel two-arm randomized superiority trial of adults undergoing elective primary knee arthroplasty for primary medial compartment OA at a single NHS hospital (ClinicalTrials.gov NCT05290818). Participants will be randomly allocated on a 1:2 basis to either raUKA or mTKA, respectively. The primary analysis will compare the Oxford Knee Score (OKS) six months after surgery. Secondary outcomes measured at three, six, and 12 months include the OKS, Forgotten Joint Score, patient expectations, EuroQol five-dimension questionnaire (EQ-5D), and EQ-visual analogue scale (EQ-VAS), patient satisfaction, range of motion, postoperative complications, need for further surgery, resource use, and financial costs. Cost-effectiveness will be measured over a ten-year time span. A total of 159 patients will be randomized (n = 53 raUKA vs n = 106 mTKA) to obtain 80% power to detect a five-point difference in OKS between the groups six months after surgery.ConclusionThe trial findings will provide evidence about the clinical and cost-effectiveness of raUKA compared to mTKA in patients with isolated medial compartment OA. This will inform future National Institute for Health and Care Excellence guidelines on primary knee arthroplasty in the UK.Cite this article: Bone Jt Open 2025;6(2):164–177.
Effect of Total Mixed Ration Feeding System on Dry Matter Intake, Nutrient Intake, and Onset of Estrus in Growing Dairy Cattle
Authors: Barros Augusto , Gundayo G F , Selvilla C C , Bautista J AN , Dizon J T , Loresco M M , Narag R AB , Angeles A A 
Published: February 2025

The objective of the study was to compare the advantages of total mixed ration (TMR) feeding versus component (COMP) feeding concerning dry matter intake (DMI) and nutrient intake in terms of crude protein (CP), neutral detergent fiber (NDF), and acid detergent fiber (ADF) intake, and the onset of estrus. A total of ten growing Holstein Frisian (HF) x Jersey breeds were randomly assigned to participate in five months of feeding trials at the Dairy Training and Research Institute. The design structure employed a randomized complete block design (RCBD) comprising five blocking factors under two treatment groups. The TMR and COMP were composed of the same feed ingredients, including corn silage, Napier grass, concentrate mash, mixed legumes, molasses, and iodized salt, and they had the same quantity and nutrient requirements. The TMR was prepared and mixed in advance, prior to the commencement of the feeding trial. In contrast, the components of the COMP were offered separately to the cattle following the specified feeding schedule. The data were collected from the daily intake of the rations offered. The feed refusal was weighed daily before the morning feeding periods, while the body weight gain (BWG) was recorded every two weeks. While samples of the offered and refused feeds were collected once a week for nutritional analysis, the data were subjected to the ANOVA procedure of SAS Statistical Software. The results demonstrated that DM, CP, NDF, and ADF intake was higher in the TMR than in the COMP group. However, the differences in means for BWG, feed conversion ratio, and the onset of estrus were not significantly different. In conclusion, TMR is expected to be beneficial in raising growing dairy cattle.
3D quadratic ODE systems with hidden oscillations
Authors: Li Yongjun , Musafirov Eduard , Grin Alexander , Pranevich Andrei 
Published: February 2025

Abstract
An autonomous three-dimensional quadratic system of ordinary differential equations with two parameters is considered. This system exhibits hidden oscillations at certain parameter values (it has a limit cycle, but does not have equilibrium points). We are looking for non-autonomous perturbations of this autonomous system that do not change the Mironenko reflecting function. Such so-called admissible perturbations preserve some qualitative properties of the solutions of the original system. For perturbed non-autonomous systems, we derived the Lyapunov stability of equilibrium solutions, proved the existence of the limit cycle and periodic solutions, as well as their stability (instability).
Ellagic acid mitigates alpha-naphthyl isothiocyanate-induced cholestasis in rats via FXR activation and inflammatory pathway modulation
Authors: Ahmed Taher Hamza , Zalzala Munaf Hashim 
Published: February 2025

Abstract

Objectives
The liver is vital for metabolism, detoxification, storage, and secretion. Cholestasis, in which bile flow is hindered, can cause serious harm to the liver. This study examines the potential of ellagic acid to prevent cholestasis in male rats that has been caused by alpha-naphthyl isothiocyanate (ANIT).

Method
Male rats were divided into four groups for an 8-day study. The control group received 5 % dimethyl sulfoxide (DMSO) orally for eight days and maize oil (1 mL/kg, orally) 48 h before sacrifice. The ANIT Group received 5 % DMSO orally for 8 days, the ANIT (100 mg/kg, orally) administered on the 6th day, 48 h before sacrifice. The low-Dose Ellagic Acid + ANIT Group was given ellagic acid (5 mg/kg, orally) for eight days, with ANIT (100 mg/kg, orally) on the 6th day, 48 h prior to sacrifice. The high-Dose Ellagic Acid + ANIT Group received ellagic acid (10 mg/kg, orally) for eight days, the ANIT (100 mg/kg, orally) on the 6th day, 48 h before sacrifice. Different biochemical and histopathological analyses were conducted to assess the protective effects of ellagic acid on ANIT-induced liver injury.

Results
ANIT significantly elevated serum of liver enzymes. It caused severe bile duct inflammation and reduced bile salt export pump (BSEP) and Na+-taurocholate cotransporting polypeptide (NTCP) expression, indicating liver injury. Ellagic acid treatment mitigated these changes, improving biochemical parameters and reducing liver damage. ANIT-induced cholestasis results in bile acid accumulation due to decreased BSEP and NTCP expression linked to impaired farnesoid X receptor (FXR) signaling. Ellagic acid restored BSEP and NTCP levels via FXR activation, reducing bile acids and inflammatory markers IL-1β and TNF-α. Ellagic acid also enhanced SIRT1 activity, further improving FXR function and bile acid homeostasis.

Conclusions
Ellagic acid exhibits protective effects against cholestasis by enhancing the FXR signaling and ntcp and bsep expression with mitigating liver damage and inflammation.
Anaerobic bacteria from bloodstream infections: Identification and antibacterial susceptibility testing in a single center in Türkiye
Authors: Orak Filiz , Karakaya Emre , Saticioğlu İzzet Burçin , Akar Mustafa , Güran Cansu , Abay Seçil , Aydin Fuat 
Published: February 2025

AbstractThis study aimed the identification of anaerobic bacteria isolated from blood cultures and the determination of antibacterial susceptibility of the isolates. The study material comprised of 5,282 blood samples taken between 2018 and 2020. The samples were incubated in a BacT/ALERT system. The species identification of the isolates was performed by three methods namely, BBL Crystal Anaerobe system, matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS), and 16S rRNA gene sequence analysis. Antibacterial susceptibility testing was performed using the disk diffusion method with benzylpenicillin, clindamycin, piperacillin-tazobactam, meropenem, and metronidazole disks. In the BacT/ALERT system, 45 anaerobic bacterial isolates were recovered from 39 (0.74%) of the samples that showed growth signs in blood culture bottles. The BBL Crystal Anaerobe system and 16S rRNA gene sequence analyses enabled the genus and species identification of all 45 isolates (100%), whereas with MALDI-TOF MS, only 37 (82.2%) of the isolates were able to be identified. Antibacterial resistance rates of the isolates to piperacillin/tazobactam, clindamycin, benzylpenicillin, meropenem, and metronidazole were detected as 100%, 73.8%, 40%, 9.8%, and 5.5%, respectively. MALDI-TOF MS showed a higher level of compatibility with 16S rRNA gene sequence analyses, compared to the BBL Crystal Anaerobe system. The high rates of susceptibility to meropenem and metronidazole suggested that these antibiotics are options for the empirical treatment of anaerobic bacterial infections.
Upgrading titania and alumina supports for NiMo hydrodesulfurization catalysts by the incorporation of 2D graphene oxide
Authors: Molina-Pérez Rodrigo Iván , Cruces-Lira Jessica , Klimova Tatiana E. 
Published: February 2025

Abstract
The synthesis and characterization of novel NiMo catalysts for hydrodesulfurization of petroleum represent a significant advancement in catalytic technology, addressing the need for efficient removal of sulfur from fossil fuels. This study explores the development of titania and alumina supports modified with graphene oxide (GO, 2 wt%) to improve the catalytic behavior of NiMo catalysts in deep hydrodesulfurization. The GO-modified supports were synthesized via a hydrothermal method. The NiMo catalysts (12 wt% MoO3 and 3 wt% NiO) were prepared by incipient wetness coimpregnation. The supports and catalysts were characterized by powder X-ray diffraction, N2 physisorption, scanning electron microscopy with energy-dispersive X-ray spectroscopy (SEM–EDS), and high-resolution transmission electron microscopy (HRTEM). The results indicate that the GO-modified supports not only provide higher surface areas to the NiMo catalysts, but also considerably improve their catalytic efficiency in the hydrodesulfurization of dibenzothiophene, probably by promoting hydrogen spillover during the reaction.

Graphical abstract
Occupational therapy in adult palliative care. A rapid review
Authors: Van Biljon Hester M. , Engelbrecht Madri , Van der Walt Janke , Soeker Shaheed M. 
Published: February 2025

Introduction: The Occupational Therapy Association of South Africa commissioned a task team to gather evidence that would inform the upcoming National Health Insurance policies on the role and practice of occupational therapists. This rapid review aimed to identify level 1 and 2 peer-reviewed published evidence that describes occupational therapists’ practice and intervention in adult palliative care.
Method: Systematic reviews and randomised control trials were searched for through the Stellenbosch University library. CINAHL (EBSCO), MEDLINE (EBSCO), the Cochrane Library (Wiley) and OTSeeker databases were used and hand searching of references in selected articles was done. Rayyan.ai was used for the screening and selection of articles. The CASP appraisal tool was used for quality assessment of the selected articles. Data was captured in Excel and Word and analysed and synthesised in Excel and Taguette.
Results: 15 articles were identified for data extraction in this rapid review. The CASP quality appraisal showed a good rating. Occupational therapists working in palliative care were reported to address: Functionality, activity participation and quality of life, symptom management related to disease and the treatment thereof, environmental modification and adaption, assistive devices and equipment, education and caregiver support and education, lifestyle adaptation, return to work or higher education/training.
Conclusion: South Africa has a unique palliative burden of care due to diseases that shorten life expectancy. Due to the unique and varied beliefs of South Africans to illness and end of life, evidence from high income countries needs to be supplemented with local knowledge to frame the role and intervention of occupational therapists in palliative care. Evidence to support and define the role of occupational therapists claims this needs to be a matter of priority.
Implications for practice

Contextually relevant palliative care intervention needs to be included in the undergraduate curriculum for occupational therapists and once they go to community service, they need to be supported in this.
Development and upskilling of occupational therapy clinicians in contextually relevant palliative practice at all levels of care need to be an available and accessible continuous professional development (CPD) activity.
Occupational therapy clinicians working on the frontlines of palliative care need to be encouraged and supported to collect and present evidence for their practices in formats and at forums where it can be used to shape policies that affect palliative adult care locally and globally.
RKM Monitoring and Evaluation System in the City of Magelang: Proposed Concept
Authors: Nuryani Ira , Primadewi Ardhin 
Published: February 2025

Local government such as Regional Development Planning Agency (Bappeda), holds an important role in budget management. For example Bappeda of Magelang City in Jawa Tengah. However, there are still several issues related to the distribution of the budget from Bappeda of Magelang City to the community. One of the issues is related to the large number of neighborhood associations (RT) managed by Bappeda, which the total is 1032 RT. The issues create a challenge in managing, distributing, and monitoring the budget effectively and efficiently. The Government of Magelang City created an Advanced, Healthy and Happy Community Empowerment Program or commonly called Rodanya Masbagia. Therefore, a monitoring system for the implementation of Rodanya Masbagia is needed for the community so that the use of funds is in accordance with the needs of the community. This system focuses on monitoring Community Needs Plan (RKM) managed by Bappeda of Magelang City, especially in managing a budget of 30 million rupiah per year for each RT. This study uses a qualitative method, including data and information collection, analysis, and observation. The sample consists of one neighborhood from each district in Magelang City, focusing on mapping the results of monitoring and evaluating programs and budgets. Therefore, the results of this system will enable Bappeda of Magelang City to monitor and evaluate the distribution of funds for each RT, ensuring compliance with the proposed plan. The business process in the optimize of SIMASBAGIA uses the Ward and Peppard Methods. Analysis is carried out using PIECES, Value Chain Analysis and Fishbone Diagram which provides a big picture of the problem in terms of various aspects. The result of this research is a proposed information system for more optimal monitoring and evaluation.
Pemanfaatan Pelayanan Posyandu sebagai Faktor Risiko Dominan Kejadian Gagal Tumbuh pada Balita di Wilayah Puskesmas Pringsurat
Authors: Putri Diah Aprilia , Suyatno Suyatno , Fatimah Siti 
Published: February 2025

Latar Belakang: Gagal tumbuh menjadi pintu masuk masalah gizi, namun upaya pemerintah seringkali tidak memperhatikan perbedaan penyebab antarwilayah. Wilayah Puskesmas Pringsurat, yang merupakan sentra pertanian, memiliki kasus gagal tumbuh tertinggi di Kabupaten Temanggung.
Tujuan: Menganalisis faktor risiko gagal tumbuh pada anak di bawah lima tahun (balita) di wilayah Puskesmas Pringsurat.
Metode: Desain penelitian case control melibatkan 104 balita (52 gagal tumbuh, 52 tidak gagal tumbuh). Subjek dipilih secara random sampling dari posyandu dengan kasus terbanyak di setiap desa di wilayah Puskesmas Pringsurat. Status gagal tumbuh ditentukan berdasarkan z-score berat badan menurut umur (BB/U) yang tidak mengalami kenaikan atau stagnan selama tiga kali penimbangan berturut-turut. Data gagal tumbuh dikumpulkan melalui penimbangan berat badan, sedang data terkait faktor-faktor gagal tumbuh diperoleh dari wawancara dan pencatatan di buku Kesehatan Ibu dan Anak (KIA), kemudian dianalisis menggunakan uji chi-square dan regresi logistik.
Hasil: Subjek lebih banyak berjenis kelamin perempuan, berusia 24-59 bulan, dengan berat lahir normal, pernah mengalami infeksi, memanfaatkan pelayanan posyandu dengan baik, memiliki pola asuh yang baik, dengan konsumsi energi yang kurang dan konsumsi protein yang cukup. Faktor risiko utama gagal tumbuh yang ditemukan adalah kurangnya pemanfaatan posyandu (OR=2,564; 95% CI [1,163-5,654]; p-value=0,019). Faktor lainnya, seperti pola asuh, infeksi, berat lahir, jenis kelamin, dan konsumsi protein, tidak menunjukkan signifikansi.
Kesimpulan: Kurangnya pemanfaatan posyandu merupakan faktor dominan penyebab gagal tumbuh pada balita di wilayah Puskesmas Pringsurat.
THE EFFECT OF EYE GYMNASTICS ON COMPUTER VISION SYNDROME IN EMMAUS SURABAYA FEMALE DORMITORY STUDENTS
Authors: Woge Kanisia Vermina , Cicilia Wahju Djajanti  , Ni Luh Agustini Purnama  
Published: February 2025

The used of gadgets was increased greatly, gadgets have many benefits in the world of education, especially for students in the learned process. Excessive used of gadgets can cause complained of eye disorders called computer vision syndrome. The phenomenon found in female students at the Emaus Putri Dormitory in Surabaya, was that most of them experienced computer vision syndrome. One of the efforted to prevented and overcome computer vision syndrome was to did eye exercised. This studied aimed to determined the effected of eye exercised on computer vision syndrome. The method used was pre-experimental with a one-group-pre-post-test design researched design. The independent variable was eye exercised and the dependent variable was computer vision syndrome. The sample size was took used a total sampling technique with a sample of 44 female students at the Emaus Girls' Dormitory Surabaya. The instrument used was the CVS-Q questionnaire and used the Wilcoxon statistical test. Based on the results of the study before eye exercised, 38 (82%) respondents experienced computer vision syndrome, and after eye exercised, the number of respondents who experienced computer vision syndrome decreased to 17 (39%). The results of the Wilcoxon test showed a p value of (0.000) < α (0.05) which means that eye exercised have an effected in reduced the score of computer vision syndrome. By to eye exercised regularly can reduced the symptoms of computer vision syndrome.

Keywords: Computer Vision Syndrome, Eye Exercises