bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anatomy of the accessory nerve and its cervical contributions in the neck
Authors: Soo Khee‐Chee , Hamlyn Peter J. , Pegington John , Westbury Gerald 
Published: February 2007

AbstractDetails of the course of the accessory nerve and the pattern of the cervical contributions to the nerve are essential for planning neck dissection. Based on a recent anatomic description, a technique was devised to preserve the distal accessory nerve; the theory advanced was that the trapezius was supplied by motor fibers from the cervical plexus, which join the accessory nerve in the posterior triangle. Dissections were performed on 23 cadavers to test such a theory. The course of the accessory nerve in the neck was mapped in each dissection, and landmarks for use during surgery determined. Cervical contributions to the nerve usually joined deep to the sternocleidomastoid, and not in the posterior triangle. Branches from the cervical plexus, independent of the accessory nerve, entered the trapezius in the posterior triangle. None of the bilateral dissections showed symmetry of the cervical contributions.
Alveolar soft part sarcoma of the tongue
Authors: Donald Paul J. 
Published: February 2007

AbstractAlveolar soft part sarcoma (ASPS) is a rare malignancy; only 39 cases have been reported in the head and neck region. A 19‐year‐old woman is presented here who had ASPS of the tongue. Surgical resection was followed by irradiation therapy. She is tumor‐free 2 years after treatment.
Phase II clinical trial of the combination VP‐16, bleomycin, and cis‐diamminedichloroplatinum in patients with advanced upper aerodigestive squamous cell carcinoma
Authors: Creagan Edward T. , Chang Myron , Long Harry J. , Rubin Joseph 
Published: February 2007

AbstractFifteen patients with advanced upper aerodigestive carcinomas of squamous cell histology received the three‐agent cytotoxic regimen of VP‐16, bleomycin, and cis‐diamminedichloroplatinum (CDDP) administered as a continuous 120‐h infusion. The objective response rate was 40%. Median times to progression and survival were 3.2 months and 4.3 months, respectively. Hematologic and gastrointestinal toxicities were relatively transient and manageable. Our experience indicates that this three‐drug program does not offer a substantial therapeutic advantage compared with more conventional single agent cytotoxic approaches for advanced head and neck cancer.
Congenital granular cell tumor of the tongue
Authors: Ophir Dov , Lifschitz Beatriz , Mogilner Benjamin M. 
Published: February 2007

AbstractGranular cell lesions in the oral cavity occur primarily on the tongue in adults (granular cell tumor) and exclusively on the alveolar ridge in newborns (congenital granular cell epulis). Because of the location, age of appearance, and certain clinical and histologic differences, these histologically similar lesions are considered separate clinical entities. This case report, however, describes the occurrence of a granular cell lesion on the tongue of a newborn. Although the etiopathogenesis of these lesions is unknown, the present case suggests a common etiologic relationship of these entities and tends to rule out an odontogenic origin for the congenital granular cell epulis.
Completion thyroidectomy for thyroid carcinoma
Authors: Rao Raja S. , Fakih Abdul R. , Mehta Ashok R. , Agarwal Rajeev , Raghavan A. , Shrikhande Sumati S. 
Published: February 2007

AbstractWe have reviewed the charts of 149 patients who underwent completion thyroidectomies for cancer of the thyroid. The purpose of the study was to evaluate extent of residual disease in the thyroid, and morbidity and mortality of the operation. Residual cancer was found in 58% of the cases, the morbidity was low, and there was no operative mortality.
Effect of epinephrine on local cutaneous blood flow
Authors: Larrabee Wayne F. , Lanier Brent J. , Miekle David 
Published: February 2007

AbstractQuantification of the effect of subcutaneous infiltration of saline with epinephrine and of lidocaine with epinephrine on local cutaneous blood flow was accomplished utilizing the laser Doppler method. A comparison of the onset of vasoconstriction, magnitude of diminished blood flow, and duration of effect was made for several commonly used concentrations of epinephrine. Injected solutions containing epinephrine in concentrations of 1: 200,000 and higher offered good vasoconstrictor effects when both the magnitude and duration of flow reduction were considered. There was a significant (P = 0.0001) difference in flow between epinephrine concentrations of 1:400,000 and all others. There were no significant differences (P > 0.05) between concentrations of 1:200,000 and 1:100,000 or 1:100,000 and 1:50,000.
Late complication of congenital hemangioma of the tongue
Authors: Brown David A. , Smith James D. 
Published: February 2007

AbstractWe present a 76‐year‐old patient with a congenitally mixed capillary/cavernous hemangioma of the tongue, which rapidly enlarged after an unrelated surgical procedure under spinal anesthesia. The enlargement resulted in a significant functional and cosmetic deformity that was corrected by surgical excision. A brief discussion of hemangiomas and their treatment is included.
A classic paper revisited—Polya and von Navratil (1902)
Authors: McGregor Alan Duncan 
Published: February 2007

AbstractIn 1902, Polya and von Navratil published a paper in German describing lymphatic drainage of buccal mucosa, alveolus, fauces, and lips. In addition, they discussed patterns of local tumor spread and metastasis to lymph nodes, on the basis of which they gave a rational plan for surgical treatment of buccal carcinoma with the aim of both cure and conservation of uninvolved tissues. Much of that paper was ignored in the English language literature and some of the contents have been misquoted. This has been to the great detriment of the surgical treatment of intraoral cancer in the English‐speaking world, which has only recently accepted similar principles and practice to that described by Polya and von Navratil. This paper reviews their publication in an attempt to put their contribution into proper perspective.
Base of tongue salivary gland tumors
Authors: De Vries Egbert J. , Johnson Jonas T. , Myers Eugene N. , Barnes E. Leon , Mandell‐Brown Mark 
Published: February 2007

AbstractSalivary tumors of the base of the tongue are encountered infrequently. A retrospective review of medical records from 1955 to 1985 was undertaken to determine the incidence of occurrence and to assess the outcome of the therapy provided. One hundred seventy‐eight minor salivary gland tumors of the oral cavity and oropharynx were identified, of which 22 (13%) were located in the tongue base. All were malignant. The most common histologic type was mucoepidermoid carcinoma (10 patients), followed by adenocarcinoma (6 patients), and adenoid cystic carcinoma (6 patients). Thirteen patients were available for a mean follow‐up of 5 years. Treatment was most often a combination of wide resection combined with postoperative radiation therapy. Ten patients (77%) are alive, one with persistent disease 8 years after diagnosis. Three patients died within 2 years of diagnosis, one with intercurrent disease. Improved control of disease in this series, when compared to previously reported series, is attributed to adequate surgical therapy and adjuvant radiotherapy. The deaths in our series occurred in patients who were unable to proceed with the recommended therapy. These unusual lesions require aggressive multimodality treatment for improved survival.
Carotid sinus hypersensitivity secondary to parapharyngeal space carcinoma
Authors: Rothstein Stephen G. , Jacobs Joseph B. , Reede Deborah L. 
Published: February 2007

AbstractCarotid sinus hypersensitivity secondary to the presence of head and neck carcinoma has been recently reviewed in the otolaryngologic literature. We present a case of carotid sinus hypersensitivity coupled with glossopharyngeal neuralgia due to tonsillar carcinoma invading the parapharyngeal space. Medical management with atropine, carbamazepine, and transvenous pacing was only moderately successful in controlling the symptomatology. Surgery appeared to offer a more permanent solution to the problem.
Cisplatin‐5‐fluorouracil chemotherapy for advanced inoperable squamous carcinoma of the head and neck
Authors: Johnson Jonas T. , Mayernik David G. , Myers Eugene N. , Nolan Teresa A. , Schramm Victor L. , Sigler Barbara S. , Wagner Robin L. 
Published: February 2007

AbstractPatients with locally advanced, inoperable squamous cell carcinoma of the head and neck were offered three courses of cisplatin and 96‐h 5‐fluorouracil (5‐FU) infusion. Subsequent therapy included surgery when feasible, irradiation therapy, and a maintenance program of methotrexate (MTX)‐5‐FU. Thirty‐three patients were evaluated prospectively. Seven patients underwent a single course of chemotherapy. Five patients underwent two courses of chemotherapy. Twenty‐one patients underwent three courses of adjuvant chemotherapy. The overall response rate was 48% (16 of 33). Fifteen of 21 patients (76%) receiving three courses of chemotherapy evidenced a response; this included three complete responses (CRs) (9%). No responses were seen in patients receiving only one or two courses of chemotherapy. Among responding patients, the initial favorable response to chemotherapy was apparent after the first course of chemotherapy. Patients who failed to demonstrate any response after two courses of chemotherapy did not respond after a third course. A significant group of patients fail to respond and should be offered participation in other investigational protocols as they become available.
Cricoarytenoid subluxation, computed tomography, and electromyography findings
Authors: Close Lanny Garth , Merkel Marie , Watson Ben , Schaefer Steven D. 
Published: February 2007

AbstractA case of cricoarytenoid subluxation secondary to endotracheal intubation and documented by computed tomography (CT) and electromyography (EMG) is reported. Successful endoscopic reduction of the displaced arytenoid is confirmed by CT. The normal anatomy and physiology of the cricoarytenoid joint is presented and the literature regarding this rarely reported injury is reviewed. Based on this review and the case reported, a treatment plan is proposed.
Anterior glossectomy: Reconstruction with a posterior tongue rotation flap
Authors: Friedman Michael , Rosenberg Matthew 
Published: February 2007

AbstractWith traditional techniques, reconstruction of the anterior tongue is often less than satisfactory. The difficulty lies mainly in providing the tongue with the appropriate amount of bulk essential for normal movement and function. We present an alternative method that involves raising a flap from the ipsilateral middle third of the tongue and rotating it into position for suturing to the anterior defect border. We have found this simple procedure to yield adequate tongue bulk for normal speech and deglutition.
Electron beam therapy for eyelid carcinomas
Authors: Sinesi Christopher , McNeese Marsha D. , Peters Lester J. , Goepfert Helmuth , Kong Joseph , Mills Michael D. 
Published: February 2007

AbstractForty‐six (85%) basal cell and eight (15%) squamous cell carcinomas of the eyelids were treated with electron beams between 1963 and 1983. Lesion sizes ranged from microscopic to 4 cm, with 28 lesions larger than 1 cm. Thirty‐eight lesions were treated with radiotherapy after incisional biopsy, and 16 were treated after excisional biopsy (specimens showed positive margins). Doses varied from 45 to 72 Gy, with daily fractions ranging from 2.12 to 4.0 Gy. There were six disease recurrences (10.9%): three in the treatment field and three at the treatment margin. Four of six recurrences were subsequently controlled by limited surgical excision and repair with preservation of the eye, whereas the other two required enucleation. Treatment sequelae such as skin atrophy, telangiectasis, and cosmetic results were evaluated in terms of radiotherapy parameters, pretreatment surgery, and size of the lesion. In 44 patients, the overall cosmetic result was judged as good to excellent, five patients had a mild to modest degree of deformity, and five had significant deformity. Such deformity was usually associated with tumor destruction or previous surgery. No major complications were noted.
Acinic cell carcinoma metastatic to the brain: Case report and ultrastructural study
Authors: Watson Peter H. , Sutherland Garnette R. , Diocee Malkit , Sima Anders A. F. 
Published: February 2007

AbstractWe report a case of isolated cerebral metastasis from an acinic cell carcinoma, which arose in minor salivary glands 20 years previously. The clinical, pathologic and ultrastructural features are described, together with a review of the literature, which suggests that this is an unusual occurrence.
Venous bypass for decompression of bleeding varices of the pharynx
Authors: Caffee H. Hollis 
Published: February 2007

AbstractBilateral radical neck dissection results in major morbidity when both jugular veins are ligated. Reported complications include massive facial edema, airway obstruction, and increased intracranial pressure. We describe a case in which a previously unreported complication of bleeding pharyngeal varices was encountered. The problem was successfully managed by decompressing the neck veins with a venous bypass using a transposition of the cephalic vein.
Growth and progression of head and neck cancer: A report of the upper aerodigestive cancer task force workshop
Authors: Schantz Stimson P. , Weber Randal S. , Carey Thomas E. 
Published: February 2007

AbstractFactors governing the initiation, growth, and progression of squamous cell carcinoma were the focus of a recent Upper Ae‐rodigestive Cancer Task Force workshop sponsored by the National Cancer Institute. The goal of the daylong workshop was to identify critical research concepts in head and neck cancer biology. Discussed were the multistep processes potentially involved in tumor evolution, including the role of carcinogens, viral promotors, host and tumor karyotypes, microenvironment growth factors and growth factor receptors, as well as host/tumor components inherent to the metastatic process. Concepts developed from research in other neoplastic processes but potentially relevant to head and neck cancer were emphasized. The process of identifying critical research directions is the first step by the National Cancer Institute in program development designed to advance the treatment of head and neck cancer.
Pulmonary lymphangitic carcinomatosis from hypopharyngeal adenosquamous carcinoma
Authors: Zieske Larry A. , Myers Eugene N. , Brown Bert M. 
Published: February 2007

AbstractAlthough pulmonary lympangitic carcinomatosis (PLC) is not uncommon for breast, bronchial, and stomach cancers, it is rarely associated with head and neck malignancy. A case of PLC is reported with the primary lesion being an adenosquamous carcinoma of the hypopharynx. A literature review is discussed, highlighting the varied radiographic picture of PLC, the possible diagnostic modalities, the proposed pathogenesis, and the treatment options. The prognosis even if antemortum diagnosis and treatment are given remains fatal, although with temporary improved quality of life and lengthened survival. There is hope that with greater awareness of the disease process an increased incidence of diagnosis may allow progress to be made in therapeutic interventions.
Analysis of survival after induction chemotherapy in pyriform sinus carcinoma
Authors: Brasnu Daniel , Fabre Alain , Menard Madeleine , Bassot Vincent , Janot Françsois , Laccourreye Henri 
Published: February 2007

AbstractThree hundred seventy‐one primary squamous cell carcinomas of the pyriform sinus were treated at Hǒpital Laennec from 1970 through 1984 and retrospectively analyzed. The local and regional treatment consisted of initial surgical resection followed by postoperative radiotherapy. Forty‐three patients were not treated by induction chemotherapy; 95 patients received preoperative chemotherapy with bleomycin as a single agent; 98 patients received three preoperative courses of vincristine, methotrexate, bleomycin, or endoxan, and 46 patients were treated by three courses of induction chemotherapy consisting of cisplatin, bleomycin, methotrexate, or 5‐fluorouracil. Seventy‐two patients received less than 150 mg of bleomycin and 17 patients received only one or two cycles of multiple‐agent chemotherapy. Survivals were higher when multiple‐agent chemotherapy was employed as compared with single‐agent induction chemotherapy. Further prospective investigations are necessary to confirm that induction chemotherapy enhances survival in pyriform sinus cancers.
Surgical management of parapharyngeal cystic hygroma causing sudden airway obstruction
Authors: Hamoir Marc , Remacle Marc , Youssif Anis , Moulin Didier , Francois Geneviègve , Claus Dominique , Kahn Andréa , Frederickx Yolande 
Published: February 2007

AbstractParapharyngeal cystic hygroma is a rare tumor of the neck. This report describes two cases in which surgical resection was necessary to overcome sudden airway obstruction and details the surgical technique. These cases were considered “near misses” for sudden infant death syndrome (SIDS) and were revealed by computed tomography (CT) and echography to be parapharyngeal cystic hygroma. The location of this malformation could have produced sudden airway collapse and be erroneously diagnosed as SIDS. The postoperative follow‐up was satisfactory and no recurrence was detected. We believe CT and echography should be included in the evaluation of such cases.
Lymphoma presenting as a salivary gland mass
Authors: Schusterman Mark A. , Granick Mark S. , Erickson E. Ralph , Newton E. Douglas , Hanna Dwight C. , Bragdon Robert W. 
Published: February 2007

AbstractA retrospective review of 36 cases of lymphoma presenting as a salivary gland mass was conducted over a 34‐year period. A significant increase in the occurrence of lymphoma was noted in proportion to other salivary gland tumors (P<0.01, X2 analysis: 1954–1972, 11 of 714 (1.5%); 1973–1979, 9 of 201 (4.5%); 1980–1987, 16 of 265 (6.0%). The mean age was 61 years, sex distribution was equal, and 75% occurred in the parotid. Only 42% presented with signs or symptoms other than a painless mass. Glandular excision was done in early stages of the disease while biopsy was done at later stages. Frozen section analysis was accurate in all but one case and was useful in determining if biopsy were adequate. All patients were definitively treated with chemotherapy and/or radiotherapy. Several instructive points are apparent. Any patient presenting with an isolated salivary gland mass can have a lymphoma. There has, in fact, been a significantly increasing proportion of salivary gland lymphoma among the various salivary gland tumors in our patient population. In contrast to other salivary gland tumors, surgery is reserved for diagnosis and not for treatment. A lymph node biopsy may be sufficient to establish a diagnosis, in which case, glandular excision is unnecessary. Most of the patients presented with an asymptomatic isolated salivary gland mass. The presence of adjacent adenopathy, a rubbery feel to the mass, and the intraoperative appearance were the most suggestive signs of lymphoma. Frozen section analysis is helpful in determining the appropriate extent of surgery and is recommended.
Adult parapharyngeal extracardiac rhabdomyoma
Authors: Stringer Scott P. , Close Lanny G. , Merkel Marie A. , Smith Herbert J. , Cohen Daniel J. 
Published: February 2007

AbstractThe case of a parapharyngeal adult extracardiac rhabdomyoma (ER) in a 69‐year‐old man is presented focusing on computed tomographic diagnosis, surgical approach, and pathologic diagnosis. Although a rare neoplasm, adult ER has a propensity for occurring in the head and neck. Systematic computed tomography evaluation with contrast serves to define the extent of the lesion and assist in the differential diagnosis of parapharyngeal masses. In this case, a transcervical extrapharyngeal approach for excision was utilized with minimal associated morbidity and a rapid return of normal function. Careful pathologic diagnosis is required to distinguish ER from other neoplasms, especially granular cell myoblastoma.
A sociotechnical approach to achieve zero defect manufacturing of complex manual assemblies
Authors: Hong Kitty , Nagarajah Romesh , Iovenitti Pio , Dunn Michelle 
Published: February 2007

AbstractTraditional approaches to defect reduction in manufacturing environments rely heavily on the introduction of technology‐based detection techniques that require significant investments in equipment and technical skills. In this article, the authors outline a novel, alternative approach that utilizes the largely untapped abilities of assembly‐line operators. Targeting zero‐defect manufacturing, the SEISMIC (stabilize, evaluate, identify, standardize, monitor, implement, and control) methodology developed herein is a sociotechnical‐based system built on the decentralization of technical knowledge and the transfer of responsibility for product quality from technical staff to manual operators. Along with defect reduction, important secondary goals of the SEISMIC methodology are improved operator performance and job satisfaction. The SEISMIC methodology provides a quantitative approach for classifying assembly environments and determining their required skill sets. Effective methods for transferring the identified skills throughout the production team are also provided. A pilot application of the protocol in an automotive assembly environment has achieved promising results in the target areas of defect reduction and operator performance. © 2007 Wiley Periodicals, Inc. Hum Factors Man 17: 137–148, 2007.