bluuebunny/crossref_metadata_2025_split huggingface dataset:
Critical issues for the diagnosis of learning disabilities in the adult population
Authors: Gregg Noel , Coleman Chris , Davis Mark , Lindstrom William , Hartwig Jennifer 
Published: September 2006

AbstractResponse to intervention (RTI) has little application to the identification of and access to accommodations for adults with learning disabilities (LD). However, the critical topics raised during the reauthorization of the Individuals With Disabilities Education Improvement Act of 2004 (IDEA; 2004) pertaining to LD eligibility criteria are similar to ongoing concerns about the provision of appropriate accommodations for adults. The real issues being challenged include three major points: (a) the relation of LD to achievement, (b) the role of clinical judgment in eligibility criteria, and (c) the purpose of diagnostic assessments. Study of the adult population is critical to a better understanding of the issues surrounding the diagnosis of LD. A review of recent research with the adult population will provide the basis for our support of the use of specific cognitive and linguistic processing measures in the diagnostic methodology for LD. © 2006 Wiley Periodicals, Inc. Psychol Schs 43: 889–899, 2006.
And never the twain shall meet: Can response to intervention and cognitive assessment be reconciled?
Authors: Willis John O. , Dumont Ron 
Published: September 2006

AbstractArguments between response to intervention (RTI) with curriculum‐based measurement (CBM) and traditional, individual psychoeducational assessments encourage a false dichotomy between alternatives that are not mutually exclusive, but complementary. This article discusses strengths and weaknesses of both approaches, touches on current legislative issues, and suggests that judicious, appropriate use of both types of assessment enhances the value of each. Initial identification of students who might need specialized instruction is better done with CBM than with individual psychoeducational assessments. RTI approaches would usually be more efficient than individual assessments and should reduce the need for such assessments. However, when RTI does not solve the problem or there are multiple, severe, and complex referral concerns, individual psychoeducational assessments are still essential. © 2006 Wiley Periodicals, Inc. Psychol Schs 43: 901–908, 2006.
The impact of parental cancer on the adolescent: an analysis of the literature
Authors: Grabiak Beth R. , Bender Catherine M. , Puskar Kathryn R. 
Published: September 2006

AbstractResearch has revealed the impact of the diagnosis of cancer on an individual, their spouse, and their family. One dimension that has received little attention is the impact of the cancer diagnosis on the patient's adolescent. This article offers an analysis of descriptive studies, intervention studies, and databased book chapters, published between 1966 and 2006, that examined the impact of parental cancer on the adolescent. The results of 45 studies and three databased book chapters are organized around four themes: adolescents' (1) emotions and behaviors (2) perceptions and knowledge of parental cancer (3) changes in roles and (4) ways of coping. These themes will assist the reader in understanding the application of the knowledge gained from the analysis of the literature to directions for future research. Copyright © 2006 John Wiley & Sons, Ltd.
Preferences of cancer patients regarding the disclosure of bad news
Authors: Fujimori Maiko , Akechi Tatsuo , Morita Tatsuya , Inagaki Masatoshi , Akizuki Nobuya , Sakano Yuji , Uchitomi Yosuke 
Published: September 2006

AbstractTo understand patients' preferences regarding the disclosure of bad news is important in the clinical oncology setting. The aim of this study was to clarify descriptively the preferences of cancer patients. Five hundred and twenty‐nine Japanese cancer outpatients were surveyed regarding their preferences regarding the disclosure of bad news, and several psychosocial and medical demographic variables were analyzed. In a descriptive analysis, more than 90% of the patients strongly preferred to discuss their current medical condition and treatment options with their physician and to have their physicians take the feelings of their family into consideration as well. While half of the patients preferred to receive information regarding their life expectancy, 30% preferred not to receive it. Multiple regression analyses indicated the preferences showing interindividual variations were associated with the level of education and the mental adjustment to cancer scores. A factor analysis revealed four preferences factors: method of disclosure of the bad news, provision of emotional support, provision of additional information, and setting. These four factors had good internal consistency reliability (Cronbach's alpha = 0.93−0.77). Providing emotional support, including the desire for the physician to show consideration for the patient's family, and understanding an individual's communication preferences may be useful for promoting patient–physician communication. Copyright © 2006 John Wiley & Sons, Ltd.
Intrinsically unstructured N‐terminal domain of bZIP transcription factor HY5
Authors: Yoon Mi‐Kyung , Shin Jieun , Choi Giltsu , Choi Byong‐Seok 
Published: September 2006

AbstractThe Arabidopsis HY5 protein is a basic leucine zipper (bZIP) transcription factor that promotes photomorphogenesis. HY5 binds directly to the promoters of light responsible element containing the G‐box and thus regulates their transcriptional activity. The level and activity of HY5 are negatively regulated, in a light‐dependent manner, by interaction with the COP1 protein, which targets HY5 for proteasome‐mediated degradation in the nucleus. Despite its essential roles in plant development, no structural information exists for HY5. In this article, we report the first structural and biophysical characterization of HY5. Using limited proteolysis in combination with mass spectrometry, circular dichroism, and nuclear magnetic resonance spectroscopy, we have deduced that the N‐terminal 77 amino acids of HY5 form a premolten globular structure, while amino acids 78–110, which constitute the basic region (BR) of the protein, exist in a molten globule state. Our studies also revealed that the overall structural features of full‐length HY5 are dominated largely by the disordered N‐terminal domain, despite the existence of a bZIP domain at its C‐terminus. We propose that HY5 is a member of the intrinsically unstructured protein (IUP) family, and that HY5 functions as an unstructured protein and benefits from being the same, in vivo. Proteins 2006. © 2006 Wiley‐Liss, Inc.
Docking of human interleukin‐15 to its specific receptor α chain: Correlation between molecular modeling and mutagenesis experimental data
Authors: Quéméner Agnès , Bernard Jérôme , Mortier Erwan , Plet Ariane , Jacques Yannick , Tran Vinh 
Published: September 2006

AbstractA structural model of the sushi domain of IL‐15Rα was first obtained by homology modeling to study its interactions with IL‐15 by means of molecular modeling, peptide scanning, and site‐directed mutagenesis. From these experimental data, a putative interacting surface of IL‐15Rα with a previously published IL‐15 model was inferred: Leu25, Leu44, and Glu46 of IL‐15 and Arg35 of IL‐15Rα were found to be key interfacial residues and were subsequently used as filters for the construction of docking solutions. Human IL‐15/IL‐15Rα complexes were constructed in two stages, with a preliminary docking procedure, treating the two partners as rigid bodies and using these filters. In this first stage, two classes of docking solutions were characterized. From a topological point of view, each solution could be derived from the other by reverse orientation of one partner in relation to the other. In a second stage, several further energy refinements clearly favored one solution. Moreover, this unique docking solution was confirmed by molecular modeling of IL‐15 mutants previously built and tested in our laboratory. Finally, this complex model, which is a useful tool to study the IL‐15/IL‐15Rα interface, was topologically compared to IL‐2/IL‐2Rα complexes (previous model in the literature and recent crystal structure). Proteins 2006. © 2006 Wiley‐Liss, Inc.
Computational and experimental approaches for assessing the interactions between the model calycin β‐lactoglobulin and two antibacterial fluoroquinolones
Authors: Eberini Ivano , Fantucci Piercarlo , Rocco Alessandro Guerini , Gianazza Elisabetta , Galluccio Lara , Maggioni Daniela , Ben Ilaria Dal , Galliano Monica , Mazzitello Rosalba , Gaiji Noura , Beringhelli Tiziana 
Published: September 2006

AbstractNorfloxacin and levofloxacin, two fluoroquinolones of different bulk, rigidity and hydrophobicity taken as model ligands, were docked to one apo and two holo crystallographic structures of bovine β‐lactoglobulin (BLG) using different computational approaches. BLG is a member of the lipocalin superfamily. Lipocalins show a typical b‐barrel structure encompassing an internal cavity where small hydrophobic molecules are usually bound. Our studies allowed the identification of two putative binding sites in addition to the calyx. The rigid docking approximation resulted in strong repulsive forces when the ligands were docked into the calyx of the apo form. On the contrary, hindrance was not experienced in flexible docking protocols whether on the apo or on the holo BLG forms, due to allowance for side chain rearrangement. Ki between 10−7 and 10−6 M were estimated for norfloxacin at pH 7.4, smaller than 10−5 M for levofloxacin. Spectroscopic and electrophoretic techniques experimentally validated the occurrence of an interaction between norfloxacin and BLG. Changes in chemical shift and dynamic parameters were observed between the 19F NMR spectra of the complex and of the ligand. A Ki (ca 10−7 M) comparable with the docking results was estimated through a NMR relaxation titration. Stabilization against unfolding was demonstrated by denaturant gradient gel electrophoresis on the complex versus apo BLG. NMR experimental evidence points to a very loose interaction for ofloxacin, the racemic mixture containing levofloxacin. Furthermore, we were able to calculate in silico Ki's comparable to the published experimental values for the complexes of palmitic and retinoic acid with BLG. Proteins 2006. © 2006 Wiley‐Liss, Inc.
Crystal structure of uncleaved L‐aspartate‐α‐decarboxylase from Mycobacterium tuberculosis
Authors: Gopalan Gayathri , Chopra Sidharth , Ranganathan Anand , Swaminathan Kunchithapadam 
Published: September 2006

AbstractL‐aspartate‐α‐decarboxylase (ADC) is a critical regulatory enzyme in the pantothenate biosynthetic pathway and belongs to a small class of self‐cleaving and pyruvoyl‐dependent amino acid decarboxylases. The expression level of ADC in Mycobacterium tuberculosis (Mtb) was confirmed by cDNA analysis, immunoblotting with an anti‐ADC polyclonal antibody using whole cell lysate and immunoelectron microscopy. The recombinant ADC proenzyme from Mycobacterium tuberculosis (MtbADC) was overexpressed in E. coli and the protein structure was determined at 2.99 Å resolution. The proteins fold into the double‐ψ β‐barrel structure. The subunits of the two tetramers (there are eight ADC molecules in the asymmetric unit) form pseudo fourfold rotational symmetry, similar to the E. coli ADC proenzyme structure. As pantothenate is synthesized in microorganisms, plants, and fungi but not in animals, structure elucidation of Mtb ADC is of substantial interest for structure‐based drug development. Proteins 2006. © 2006 Wiley‐Liss, Inc.
Alice: An information‐rich autonomous vehicle for high‐speed desert navigation
Authors: Cremean Lars B. , Foote Tully B. , Gillula Jeremy H. , Hines George H. , Kogan Dmitriy , Kriechbaum Kristopher L. , Lamb Jeffrey C. , Leibs Jeremy , Lindzey Laura , Rasmussen Christopher E. , Stewart Alexander D. , Burdick Joel W. , Murray Richard M. 
Published: September 2006

AbstractThis paper describes the implementation and testing of Alice, the California Institute of Technology's entry in the 2005 DARPA Grand Challenge. Alice utilizes a highly networked control system architecture to provide high performance autonomous driving in unknown environments. Innovations include a vehicle architecture designed for efficient testing in harsh environments, a highly sensory‐driven approach to fuse sensor data into speed maps used by real‐time trajectory optimization algorithms, health and contingency management algorithms to manage failures at the component and system level, and a software logging and display environment that enables rapid assessment of performance during testing. The system successfully completed several runs in the National Qualifying Event, but encountered a combination of sensing and control issues in the Grand Challenge Event that led to a critical failure after traversing approximately 8 miles. © 2006 Wiley Periodicals, Inc.
Intelligent off‐road navigation algorithms and strategies of Team Desert Buckeyes in the DARPA Grand Challenge 2005
Authors: Chen Qi , Özgüner Ümit 
Published: September 2006

AbstractThis paper describes one aspect of our approach in developing an intelligent off‐road autonomous vehicle, the Intelligent Off‐Road Navigator (ION), as Team Desert Buckeyes from the Ohio State University for the DARPA Grand Challenge 2005. The real‐time navigation is one of the critical components in an autonomous ground vehicle system. In this paper, we focus on the navigation module, whose main responsibility is to generate smooth and obstacle‐free local paths with appropriate speed setpoints. For the smooth path generation, we introduce a polynomial interpolation method. To generate obstacle‐free paths, a steering controller utilizing a fuzzy obstacle avoidance algorithm is presented. A speed fuzzy controller is introduced to generate the speed setpoints. These two fuzzy controllers collaborate with each other to guide our vehicle ION to the goal safely. The obstacle avoidance algorithm proposed in this paper was also tested in simulations and on small robots successfully. Other issues related to the navigation module are discussed in the paper as well, such as the vehicle's system structure and its finite state machine. As a result, ION achieved great performance in the National Qualification Event, covered about 30 miles in the Nevada Desert with complete autonomous operations, and finished 10th in the Grand Challenge 2005. © 2006 Wiley Periodicals, Inc.
Prospect Eleven: Princeton University's entry in the 2005 DARPA Grand Challenge
Authors: Atreya Anand R. , Cattle Bryan C. , Collins Brendan M. , Essenburg Benjamin , Franken Gordon H. , Saxe Andrew M. , Schiffres Scott N. , Kornhauser Alain L. 
Published: September 2006

AbstractThis paper describes Princeton University's approach to the 2005 DARPA Grand Challenge, an off‐road race for fully autonomous ground vehicles. The system, Prospect Eleven, takes a simple approach to address the problems posed by the Grand Challenge, including obstacle detection, path planning, and extended operation in harsh environments. Obstacles are detected using stereo vision, and tracked in the time domain to improve accuracy in localization and reduce false positives. The navigation system processes a geometric representation of the world to identify passable regions in the terrain ahead, and the vehicle is controlled to drive through these regions. Performance of the system is evaluated both during the Grand Challenge and in subsequent desert testing. The vehicle completed 9.3 miles of the course on race day, and extensive portions of the 2004 and 2005 Grand Challenge courses in later tests. © 2006 Wiley Periodicals, Inc.
Virginia Tech's twin contenders: A comparative study of reactive and deliberative navigation
Authors: Leedy Brett M. , Putney Joseph S. , Bauman Cheryl , Cacciola Stephen , Michael Webster J. , Reinholtz Charles F. 
Published: September 2006

AbstractThere are two commonly accepted paradigms for organizing intelligence in robotic vehicles, namely, reactive and deliberative. Although these paradigms are well known to researchers, there are few published examples directly comparing their development and application on similar vehicles operating in similar environments. Virginia Tech's participation, with two nearly identical vehicles in the DARPA Grand Challenge, afforded a practical opportunity for such a case study. The two Virginia Tech vehicles, Cliff and Rocky, proved capable of off‐road navigation, including road following and obstacle avoidance in complex desert terrain. Under the conditions of our testing, the reactive paradigm developed for Cliff produced smoother paths and proved to be more reliable than the deliberative paradigm developed for Rocky. The deliberative method shows great promise for planning feasible paths through complex environments, but it proved unnecessarily complex for the desert road navigation problem posed by the Grand Challenge. This case study, while limited to two specific software implementations, may help to shed additional light on the tradeoffs and performance of competing approaches to machine intelligence. © 2006 Wiley Periodicals, Inc.
MITRE Meteor: An off‐road autonomous vehicle for DARPA's Grand Challenge
Authors: Grabowski Robert , Weatherly Richard , Bolling Robert , Seidel David , Shadid Michael , Jones Ann 
Published: September 2006

AbstractThe MITRE Corporation's (McLean, VA) Meteor team fielded an autonomous vehicle that competed in DARPA's 2005 Grand Challenge race. This paper describes the team's approach to building its robotic vehicle, the vehicle and components that let the vehicle see and act, and the computer software that made the vehicle autonomous. Also presented are details of how the team prepared for the race and how their vehicle performed. © 2006 Wiley Periodicals, Inc.
Simultaneous mobility: analytical framework, theorems and solutions
Authors: Daniel Wong K. , Dutta A. , Schulzrinne H. , Young K. 
Published: September 2006

AbstractThe original Mobile IP (MIP) protocol does not perform Route Optimisation but uses Home Agents to forward traffic. Thus, it does not have problems with simultaneous mobility, that is, the special case when both end hosts are mobile and move at about the same time. However, MIP for IPv6 (MIPv6) uses binding updates that are sent directly to a correspondent node. Session Initiation Protocol based mobility management (SIPMM) and MIP with location registers (MIP‐LR) also use direct binding updates between a mobile host and a correspondent node. Thus, MIPv6, MIP‐LR and SIPMM are vulnerable to the simultaneous mobility problem. In this paper, we analyse the simultaneous mobility problem and solution mechanisms, and propose new ways for MIPv6, MIP‐LR and SIPMM to handle simultaneous mobility. Copyright © 2006 John Wiley & Sons, Ltd.
SIPv6 analyzer: an analysis tool for 3GPP IMS services
Authors: Chen Whai‐En , Sung Yueh‐Hsin , Lin Yi‐Bing 
Published: September 2006

AbstractThe 3rd Generation Partnership Project (3GPP) defines IP Multimedia Core Network Subsystem (IMS) to support IP‐based multimedia services. IMS utilizes protocols such as IP version 6 (IPv6), Session Initiation Protocol (SIP), and Real‐time Transport Protocol (RTP) to deliver the multimedia content. This paper proposes an analysis tool referred to as SIPv6 Analyzer to investigate the IMS‐related protocols during IMS service deployment. The SIPv6 Analyzer not only dissects the protocol headers but also provides user‐friendly functions such as message flow generation and audio/video replay for IPv6, SIP, and RTP. We describe the design of the SIPv6 Analyzer and use examples to illustrate how it works. Copyright © 2006 John Wiley & Sons, Ltd.
Capacity optimizing channel allocation schemes for multi‐service cellular systems with mobile users
Authors: Yang Ming , Chong Peter H. J. 
Published: September 2006

AbstractIn this paper, we study the blocking and dropping probability of mobile users in the multi‐service cellular systems with mobile users. Based on the idea that different services may require different signal‐to‐interference ratios and different reuse factors, we proposed a channel allocation scheme calledchannel partitioningto support different services using different reuse factors. Under channel partitioning scheme, the channels in each cell are divided into two or more sets of channels and each set of the channels supports certain service, depending on the required reuse factor of the service. We first apply this channel partitioning with fixed channel allocation scheme called fixed channel partitioning (FCP), where a three‐dimensional Markov chain is developed to analyze the impact of the mobile user. After that a simpler model, which can estimate the numeric result from the closed‐form solution, is presented to make the analysis easier. In order to cater for the traffic variation between services and between cells, a dynamic channel partitioning with flexible channel combination scheme, called FDCP, is proposed to support multiple services. This FDCP tries to minimize the effect of assigned channels on the availability of channels for use in the interfering cells. The analysis and the simulation results show that for equal arrival rate of two services, the proposed FCP and FDCP scheme can provide about 32% and 54% improvement, respectively, in terms of grade of service as compared with conventional FCA scheme using a single reuse factor to support two services for the mobile users. Copyright © 2006 John Wiley & Sons, Ltd.
Optimization of ethanol production from starch by an amylolytic nuclear petite Saccharomyces cerevisiae strain
Authors: Toksoy Öner Ebru 
Published: September 2006

AbstractEthanol fermentation characteristics of the 100% respiratory‐deficient nuclear petite amylolytic Saccharomyces cerevisiae NPB‐G strain was investigated in both shake‐flask and controlled bioreactor cultivation conditions, and comparison with the earlier reported results revealed 54.6% increase in ethanol yield. Efforts to improve the starch utilization rate by increasing the selection pressure or supplying the fermentation medium with glucose did not prevent the observed decrease in time‐dependent amylolytic activity. Response surface methodology (RSM) was then used as a statistical tool to optimize the initial yeast extract and starch contents of the medium, which resulted in a substantial increase in the stability of the expression plasmid in both the respiratory‐deficient NPB‐G and the parental respiratory‐sufficient WTPB‐G strains, with concomitant improvement in their amylolytic potentials. High ethanol yields on substrate values of the bioreactor cultures, which were very close to the theoretical yield, indicated that the amylolytic respiratory‐deficient NPB‐G strain was effective in the direct fermentation of starch into ethanol. Copyright © 2006 John Wiley & Sons, Ltd.