bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cornelia de Lange syndrome (CdLS): prenatal and autopsy findings
Authors: Chong Karen , Keating Sarah , Hurst Stephanie , Summers Anne , Berger Howard , Seaward Gareth , Martin Nicole , Friedberg Tami , Chitayat David 
Published: February 2009

AbstractCornelia de Lange Syndrome (CdLS) is a multisystem disorder characterized by somatic defects and mental retardation. Prenatal diagnosis of this severe condition is difficult in view of the non‐specific ultrasound abnormalities. We report three cases with prenatally suspected CdLS based on the ultrasound findings as well as low PAPP‐A detected on first trimester screening in one case, and the results of the autopsy and the NIPBL gene mutation analysis. Copyright © 2009 John Wiley & Sons, Ltd.
An evaluation of the decision‐making process regarding amniocentesis following a screen‐positive maternal serum screen result
Authors: Kobelka Christine , Mattman André , Langlois Sylvie 
Published: February 2009

AbstractObjectivesTo identify the decision‐making factors and personal characteristics of women who opt for and against amniocentesis following a screen‐positive maternal serum screen (MSS) result.MethodsA questionnaire was mailed to 597 women who were randomly selected among women in the province of British Columbia (BC) who screened positive for Down syndrome (DS) on the MSS between January and June 2005. Subjects were evenly distributed across two main parameters: screen‐positive women who opted for, and declined, amniocentesis (Groups 1 and 2, respectively).ResultsSignificant differences (P < 0.05) between Groups 1 and 2 include; reasons for wanting the MSS, post‐positive MSS anxiety level, risk of miscarriage associated with amniocentesis, MSS risk estimate, reasons for wanting, or not wanting amniocentesis, normal fetal ultrasound, attitudes towards termination and religious beliefs. About half of all women across both groups did not find the MSS helpful in their pregnancy, primarily stating that it caused unnecessary increased anxiety.ConclusionsTo help avoid, or at least prepare women for the likelihood of increased anxiety following a screen‐positive MSS result, and help prepare them for decision making, it is important to target MSS counselling to the individuality of the patient, and address these factors before MSS is undertaken. Copyright © 2009 John Wiley & Sons, Ltd.
Effects of solvent, film thickness, and hydrogen bonding on surface‐relief gratings
Authors: Jung Woo‐Hyuk , Lee Ki‐Tae , Lee Dong‐Han , Han Sang‐Cheol , Kim Yang , Lee Jang‐Oo 
Published: February 2009

AbstractThis work focuses on the development of a new type of surface‐relief grating (SRG) using more effective materials than a typical epoxy‐based azopolymer for the recording layer of optical data storage. Thus, aniline‐based azopolymers were synthesized by reaction of N,N‐diglycidylaniline with aniline (An) followed by diazocoupling with 4‐aminobenzonitrile or 4‐nitroaniline. Such azopolymers when spin‐cast from THF/dioxane showed better diffraction efficiency than those cast from THF alone due to residual dioxane creating a large free volume in the solid state. A second diazocoupling reaction of the diazopolymers initially obtained produced polymers with bis(diazobenzene) substituents which exhibited a higher saturation level of the diffraction efficiency for a thicker than for a thinner film. Azopolymers in which the diazo substituents incorporated hydroxyl groups ortho to the diazo unit were obtained via the reaction of the diglycidyl ether of bisphenol‐A with aniline or 3‐hydroxyaniline followed by coupling with diazotised hydroxynitroaminobenzene. These hydroxy groups, presumably as a result of their H‐bonding to the diazo‐N, effectively prevented the photoisomerization of the chromophores, so that the polymers showed no SRG at a normal laser intensity of 100 mW/cm2. Polyurethane‐based azopolymers, synthesized with toluene‐2,4‐diisocyanate and disperse orange 17 containing no hydroxyl groups in the main chains, showed better diffraction efficiency than the other azopolymers with nitro group substituents. POLYM. ENG. SCI., 2009. © 2009 Society of Plastics Engineers
Studies on fluorescent PVA + PVP + MPDMAPP composite films
Authors: Bhajantri R.F. , Ravindrachary V. , Poojary Boja , Ismayil  , Harisha A. , Crasta Vincent 
Published: February 2009

AbstractPolymer blends along with 1‐(4‐methylphenyl)‐3‐(4‐N,N, dimethyl amino phenyl)‐2‐propen‐1‐one (MPDMAPP) NLO‐chromophore‐doped composite films were prepared by solvent casting method using DMF. The optical properties were studied using UV–visible, refractive index, steady state fluorescence, and fluorescence microscopic imaging techniques. The UV–vis absorption spectra showed three absorption bands and were assigned to localized n → π*, n → π* inter band, and π → π* transition of charge transfer groups. The observed changes in the absorption peak, edges, and intensity with dopant concentration are understood based on charge transfer complex (CTC) formation. The refractive indices of the composite films varied from 1.4937–1.5398 for red and 1.5165–1.5516 for green light respectively. The steady state fluorescence data showed both emission peak wavelengths and intensity changes with MPDMAPP doping level in blend. The fluorescence anisotropy (r) variations in the composite films indicate the suppressed molecular motion of MPDMAPP in the solid composite film. The fluorescence microscopic image of these composite films showed that the films are photochromatic in nature. These modified properties are thought to be due to the charge transfer upon excitation from the donor to the acceptor connected through benzene ring and CTC formation. POLYM. ENG. SCI., 2009. © 2009 Society of Plastics Engineers
Quantitative identification of protein nitration sites
Authors: Chiappetta Giovanni , Corbo Claudia , Palmese Angelo , Marino Gennaro , Amoresano Angela 
Published: February 2009

AbstractSeveral labelling strategies have been developed targeting specific amino acid residues and/or PTMs. Methods specifically tailored for the qualitative and sometimes quantitative determination of PTMs have emerged. Many research groups have focused their attention towards o‐nitrotyrosine residues, developing various methodologies for their identification, while direct quantification has remained elusive. So far the iTRAQ chemistry has been limited to primary amines. Here, we report a new strategy based on the use of iTRAQ reagents coupled to MS analysis for the selective labelling of o‐nitrotyrosine residues. This method was proved to lead to the simultaneous localisation and quantification of nitration sites both in model proteins and in biological systems.
Proteomic analysis of multidrug‐resistance mechanisms in adriamycin‐resistant variants of DLKP, a squamous lung cancer cell line
Authors: Keenan Joanne , Murphy Lisa , Henry Michael , Meleady Paula , Clynes Martin 
Published: February 2009

AbstractAlterations in protein expression associated with adriamycin resistance in a panel of variants derived from the poorly differentiated squamous cell lung carcinoma DLKP were investigated using 2‐D DIGE. Of the 80 proteins identified as being differentially expressed, 32 correlated to adriamycin resistance. Twenty‐four proteins showed positive correlations with drug resistance, 11 correlated directly with increase in the resistance (including NDPK, RPA2, CCT2, HSP70 and Annexin A1) while 13 proteins (including HNRP K and H1, aldehyde dehydrogenase (ALDH), stomatin and CCT3) increased to a similar level in all drug‐resistant variants. Fewer proteins showed an inverse correlation with resistance; two (protein disulphide isomerase (PDI) and HSP70 variant 1) displayed a similar decrease in all variants and six (including prohibitin (PHB) and EIF5A) correlated inversely with resistance. Three proteins (EEF1D, Actin G1 and Annexin 1) correlated with the invasive status of these variants. Some expected targets of adriamycin action showed correlation with resistance including RPA2 (critical for DNA damage repair), while others proteins involved in protection from ROS production (such as GST, peroxiredoxins and thioredoxins) did not. The proteomic analysis revealed a large number of changes in protein expression that may contribute to a more apoptosis‐resistant state. Many of these changes could provide novel targets for overcoming resistance.
Home‐based exercise among cancer survivors: adherence and its predictors
Authors: Pinto Bernardine M. , Rabin Carolyn , Dunsiger Shira 
Published: February 2009

AbstractObjective: Evidence of the benefits of exercise for those treated for cancer has led to exercise interventions for this population. Some have questioned whether cancer patients offered a home‐based intervention adhere to the exercise prescribed.Method: We examined exercise adherence in a randomized controlled trial of a 12‐week, home‐based exercise trial for breast cancer patients. Three adherence outcomes were examined: minutes of exercise participation/week, number of steps taken during planned exercise/week, and whether the participant met her weekly exercise goal. Predictors of adherence (e.g. demographic and medical variables, Transtheoretical Model variables, history of exercise) were examined.Results: Findings indicate that participants significantly increased their minutes of exercise and steps taken during planned exercise from Week 1 to 12. The percentage of participants achieving exercise goals was highest in the first few weeks. Exercise self‐efficacy significantly predicted each adherence outcome. Baseline PA predicted mean exercise session steps over the 12 weeks.Conclusion: Adherence to a home‐based exercise intervention for breast cancer patients changes over time and may be related to baseline levels of exercise self‐efficacy. Copyright © 2009 John Wiley & Sons, Ltd.
Development, feasibility and efficacy of a community‐based exercise training program in pediatric cancer survivors
Authors: Takken Tim , van der Torre Patrick , Zwerink Marlies , Hulzebos Erik H. , Bierings Marc , Helders Paul J. M. , van der Net Janjaap 
Published: February 2009

AbstractObjective: The aim of this study was to develop a 12‐week exercise training program (comprising aerobic and strength exercises), and to study the feasibility and efficacy of this exercise program in children who survived acute lymphoblastic leukemia.Sample and methods: A 12‐week exercise program was developed and tested for feasibility in nine children who survived cancer.Results: From the 16 eligible children for the intervention, 9 participated, while 4 were able to complete the entire program. Feasibility of the program was scored by five children, two of them reported the program as being too demanding. The participating physiotherapists were satisfied with training methodology and training progress. The efficacy of the program on muscle strength, exercise capacity, functional mobility and fatigue showed no significant differences between pre and post training.Conclusion: In designing a community‐based exercise training program, not only the stage of the disease needs to be considered, but more so the age of the children, the variety of exercises, the location of implementation and even more importantly the views and motivation of the parents concerning the execution of an exercise training program. A careful balance between these parameters could lead to a greater adherence and by that, to a better outcome of these programs. Copyright © 2009 John Wiley & Sons, Ltd.
Restorative yoga for women with breast cancer: findings from a randomized pilot study
Authors: Danhauer Suzanne C. , Mihalko Shannon L. , Russell Gregory B. , Campbell Cassie R. , Felder Lynn , Daley Kristin , Levine Edward A. 
Published: February 2009

AbstractObjectives: Restorative yoga (RY) is a gentle type of yoga that may be beneficial for cancer patients and post‐treatment survivors. Study goals were: to determine the feasibility of implementing a RY intervention for women with breast cancer; and to examine group differences in self‐reported emotional, health‐related quality of life, and symptom outcomes.Methods: Women with breast cancer (n=44; mean age 55.8 years) enrolled in this study; 34% were actively undergoing cancer treatment. Study participants were randomized to the intervention (10 weekly 75‐minute RY classes) or a waitlist control group. Participants completed questionnaires at Week 0 (baseline) and Week 10 (immediately post‐intervention for the yoga group).Results: Group differences favoring the yoga group were seen for mental health, depression, positive affect, and spirituality (peace/meaning). Significant baseline*group interactions were observed for negative affect and emotional well‐being. Women with higher negative affect and lower emotional well‐being at baseline derived greater benefit from the yoga intervention compared to those with similar values at baseline in the control group. The yoga group demonstrated a significant within‐group improvement in fatigue; no significant difference was noted for the control group.Conclusions: Although limited by sample size, these pilot data suggest potential benefit of RY on emotional outcomes and fatigue in cancer patients. This study demonstrates that a RY intervention is feasible for women with breast cancer; implications for study design and implementation are noted with an emphasis on program adoption and participant adherence. Copyright © 2009 John Wiley & Sons, Ltd.
Exercise and quality of life during and after treatment for breast cancer: results of two randomized controlled trials
Authors: Cadmus Lisa A. , Salovey Peter , Yu Herbert , Chung Gina , Kasl Stanislav , Irwin Melinda L. 
Published: February 2009

AbstractObjective: To determine the effect of exercise on quality of life in (a) a randomized controlled trial of exercise among recently diagnosed breast cancer survivors undergoing adjuvant therapy and (b) a similar trial among post‐treatment survivors.Methods: Fifty newly diagnosed breast cancer survivors were recruited through a hospital‐based tumor registry and randomized to a 6‐month, home‐based exercise program (n=25) or a usual care group (n=25). In a separate trial, 75 post‐treatment survivors were randomized to a 6‐month, supervised exercise intervention (n=37) or to usual care (n=38). Participants in both studies completed measures of happiness, depressive symptoms, anxiety, stress, self‐esteem, and quality of life at baseline and 6 months.Results: Forty‐five participants completed the trial for newly diagnosed survivors and 67 completed the trial for post‐treatment survivors. Good adherence was observed in both studies. Baseline quality of life was similar for both studies on most measures. Exercise was not associated with quality of life benefits in the full sample of either study; however exercise was associated with improved social functioning among post‐treatment survivors who reported low social functioning at baseline (p<0.05).Conclusions: Exercise did not affect quality of life in either recently diagnosed or post‐treatment breast cancer survivors; however this may be due in part to relatively high baseline functioning among participants in both studies. Strategies for future research include limiting enrollment to survivors who report reduced quality of life on screening questionnaires and targeting survivor subgroups known to be at particular risk for quality of life impairment. Copyright © 2009 John Wiley & Sons, Ltd.
A telephone‐delivered lifestyle intervention for colorectal cancer survivors ‘CanChange’: a pilot study
Authors: Hawkes Anna L. , Gollschewski Sara , Lynch Brigid M. , Chambers Suzanne 
Published: February 2009

AbstractObjective: To investigate the feasibility and short‐term effectiveness of a lifestyle intervention for colorectal cancer (CRC) survivors.Methods: CanChange was telephone‐delivered to 20 CRC survivors by health coaches over 6 weeks supported by an interactive participant handbook. We assessed program feasibility (program retention and satisfaction) and health outcomes [CRC‐specific symptoms (fatigue, nausea, diarrhoea), quality of life (QOL), and lifestyle variables (physical activity, dietary intake, alcohol intake, smoking, body mass index (BMI))] at baseline and post‐intervention.Results: Post‐intervention, 76% of participants rated the program as excellent, 100% rated the health coach as excellent, and 75% rated the handbook as excellent. In addition, 80% said that CanChange addressed their issues, 72% said that CanChange helped them deal more effectively with their problems, and 100% said that CanChange made them more motivated to make positive life changes. Finally, all participants said that they would recommend CanChange to other CRC survivors.From baseline to post‐intervention we observed: non‐significant improvements in all CRC‐specific symptoms and QOL; a significant decrease in processed meat intake [median (interquartile range): 1.0 (3.0) vs 0.0 (1.0), p=0.01]; as well as non‐significant improvements in sedentary behaviour, and the proportion of participants meeting the national guidelines for fruit and vegetable intake. We observed no change in smoking status, while the results for alcohol intake, physical activity, and BMI were variable.Conclusions: CanChange was a feasible and potentially effective lifestyle intervention to improve health outcomes for CRC survivors. A large randomised controlled trial will follow to test the longer‐term effects of this approach. Copyright © 2009 John Wiley & Sons, Ltd.
Nd3+‐ion luminescence in La2O2S and Y2O2S single crystals
Authors: Abutalibov G. I. , Guseynov D. I. , Mamedov A. A. 
Published: February 2009

AbstractLa2O2S and Y2O2S single crystals with Nd3+ ions have been studied by selective laser excitation method to demonstrate its effectiveness for detection of the fine structure of the radiation spectra of Nd3+ ions. The energies of Stark components of the basic multiplets of Nd3+ ions have been determined. (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Hall effect in the new diluted magnetic semiconductor p‐CdSb:Ni
Authors: Laiho R. , Lashkul A. V. , Lisunov K. G. , Lähderanta E. , Shakhov M. A. , Zakhvalinskii V. S. 
Published: February 2009

AbstractThe Hall effect is investigated in oriented single crystals of a new diluted group II‐V semiconductor p‐CdSb doped with 2 at% of Ni in the temperature interval of T = 1.5–300 K and pulsed magnetic fields up to B = 25 T. A non‐linear dependence of the Hall resistivity, ρH, on B is observed, which is strongly pronounced below ∼10 K and still exists even up to 300 K. From the analysis of ρH(B) a positive normal, ρN = R0B, and a negative anomalous, ρA, contributions are obtained. The normal Hall coefficient, R0, is determined presumably by activation of holes into the valence band, accompanied with a minor contribution of itinerant holes from the acceptor band at lowest T, whereas ρA below ∼77 K scales with resisitivity approximately as ρn (n = 1.6 ± 0.1). The anomalous contribution to the Hall effect is attributable to presence of magnetic Ni1–xSbx nanoclusters, which have been found previously from investigation of magnetic properties of p‐CdSb:Ni. (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
The diurnal evolution of cold fronts in the Australian subtropics
Authors: Thomsen Gerald L. , Reeder Michael J. , Smith Roger K. 
Published: February 2009

AbstractThe effect of the diurnal cycle on the evolution of cold fronts in the Australian subtropics is investigated in two high‐resolution numerical simulations. The simulations are made using the Pennsylvania State University/National Center for Atmospheric Research Mesoscale Model (MM5) with the initial and boundary conditions taken from the operational analyses of the European Centre for Medium‐range Weather Forecasts. These simulations are compared with the observations of two cold fronts taken during the Central Australian Fronts Experiment in 1991. The simulations show a number of features that have been suspected, but never confirmed or quantified: (i) although the wind field in the boundary layer is frontogenetic, daytime turbulent mixing is strongly frontolytic, which accounts for the weakening and deceleration of the fronts during the late morning and afternoon when convective mixing in the boundary layer is most vigorous; (ii) when the mixing subsides in the early evening, the low‐level winds increase along with the deformation and convergence, leading to a strengthening and acceleration of the fronts; (iii) bore‐like disturbances are generated during the early hours of the morning as the nocturnal inversion strengthens. These bores propagate ahead of the front, developing a series of large‐amplitude waves at their leading edge. Copyright © 2009 Royal Meteorological Society
Characterization of oligomeric compounds in secondary organic aerosol using liquid chromatography coupled to electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry
Authors: Müller Lars , Reinnig Marc‐Christopher , Hayen Heiko , Hoffmann Thorsten 
Published: February 2009

AbstractThe components of secondary organic aerosols (SOAs) generated from the gas‐phase ozonolysis of two C10H16‐terpenes (α‐pinene; sabinene) and a cyclic C6H10 alkene (cyclohexene) were characterized by the use of a Fourier transform ion cyclotron mass spectrometer equipped with an electrospray ionization source operated in the negative ion mode. Reversed‐phase high‐performance liquid chromatography was used to achieve chromatographic separation of highly oxidized organic compounds. In addition to the well‐known group of low molecular weight oxidation products (monomers; e.g. dicarboxylic acids), higher molecular weight compounds (dimers) were also detected and their exact elemental compositions were determined. In order to provide additional information for the structural elucidation of these compounds, collision‐induced dissociation was applied. Based on the MS/MS spectra, two higher molecular weight products are proposed to be an ester and a peroxide. Molecular formulae calculated from the exact masses show that the SOA‐compounds are heavily oxidized and this information creates the background to a discussion of potential reaction pathways for the formation of higher molecular weight compounds. Copyright © 2009 John Wiley & Sons, Ltd.
Imaging Viral Behavior in Mammalian Cells with Self‐Assembled Capsid–Quantum‐Dot Hybrid Particles
Authors: Li Feng , Zhang Zhi‐Ping , Peng Jun , Cui Zong‐Qiang , Pang Dai‐Wen , Li Ke , Wei Hong‐Ping , Zhou Ya‐Feng , Wen Ji‐Kai , Zhang Xian‐En 
Published: February 2009

AbstractUnique spectral properties of quantum dots (QDs) enable ultrasensitive and long‐term biolabeling. Aiming to trace the infection, movement, and localization of viruses in living cells, QD‐containing virus‐like particles (VLPs) of simian virus 40 (SV40), termed SVLP‐QDs, are constructed by in vitro self‐assembly of the major capsid protein of SV40. SVLP‐QDs show homogeneity in size (≈24 nm), similarity in spectral properties to unencapsidated QDs, and considerable stability. When incubated with living cells, SVLP‐QDs are shown to enter the cells by caveolar endocytosis, travel along the microtubules, and accumulate in the endoplasmic reticulum. This process mimics the early infection steps of SV40. This is the first paradigm of imaging viral behaviors with encapsidated QDs in living cells. The method may provide a new alternative for various purposes, such as tracing viruses or viral components, targeted nanoparticle delivery, and probing of drug delivery.