bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Unique Temperature‐Induced Reverse Supramolecular Chirality‐Assisted Gel‐to‐Gel Transition
Authors: Duraisamy Dinesh Kumar , Reddy Samala Murali Mohan , Saveri Puchalapalli , Deshpande Abhijit P. , Shanmugam Ganesh 
Published: March 2024

AbstractSupramolecular hydrogels typically undergo a gel‐to‐sol transition with heat, as intermolecular interactions within the gel weaken. Although gel‐to‐gel transitions during heating are rare, they may occur due to minor rearrangements caused by thermal forces in the supramolecular self‐assembled structure. Here, an unprecedented temperature‐induced gel‐to‐gel transition assisted by supramolecular chiral inversion in a hydrogel system is presented. The transition results from a left‐handed M‐type helix to a right‐handed P‐type helix, attributed to the π‐system‐conjugated amino acid, l‐Tyrosine (Fm‐ l‐Tyr). Upon solvent dilution, Fm‐l‐Tyr induces translucent hydrogel formed by entangled fibers with a kinetically stable left‐handed M‐type supramolecular helix. At 70 °C, hydrogel transforms into an opaque gel with a reverse supramolecular chirality yielding a thermodynamically stable right‐handed P‐type helix. Supramolecular chiral inversion is substantiated by two chiroptical methods. This unique gel‐to‐gel transition, accompanied by chiral inversion, is anticipated to attract attention, especially for applications sensitive to chirality.
Neuroprotective effects of repetitive transcranial magnetic stimulation on Alzheimer's disease: Undetermined therapeutic protocols and mechanisms
Authors: Zhu Yang , Liao Lingyi , Gao Shihao , Tao Yong , Huang Hao , Fang Xiangqin , Yuan Changyan , Gao Changyue 
Published: March 2024

AbstractAlzheimer's disease (AD) is a prevalent neurodegenerative disorder characterized by gradual deterioration of cognitive functions, for which an effective treatment is currently unavailable. Repetitive transcranial magnetic stimulation (rTMS), a well‐established noninvasive brain stimulation method, is utilized in clinical settings to address various neuropsychiatric conditions, such as depression, neuropathic pain, and poststroke dysfunction. Increasing evidence suggests that rTMS may enhance cognitive abilities in individuals with AD. However, its optimal therapeutic protocols and precise mechanisms are currently unknown, impeding its clinical implementation. In the present review, we aimed to summarize and discuss the efficacy‐related parameters in rTMS treatment, encompassing stimulus frequency, stimulus pattern, stimulus intensity, and the configuration of the stimulus coil. Furthermore, we reviewed promising rTMS therapeutic protocols involving various combinations of these factors, that were examined in clinical studies. Based on our analysis, we propose that a multisite high‐frequency rTMS (HF‐rTMS) regimen has value in AD therapy, and that promising single‐site protocols, such as HF‐rTMS, applied over the left dorsolateral prefrontal cortex, precuneus, or cerebellum are required to be validated in larger clinical studies. Lastly, we provide a comprehensive review of the potential mechanisms underlying the neuroprotective effects of rTMS on cognition in AD in terms of brain network modulation as well as cellular and molecular reactions. In conclusion, the interaction of diverse mechanisms may be responsible for the total therapeutic effect of rTMS on AD. This review provides theoretical and practical evidence for the future clinical application and scientific research of rTMS in AD.
Beyond the model organism—Mechanistic analysis of protein post‐translational modifications is ready for all challengers
Authors: Orsburn Benjamin C. 
Published: March 2024

AbstractA historic challenge for shotgun proteomics has been the requirement for high quality, simple, and nonredundant curated protein sequences in small .fasta text files. Due to the intrinsic informatic challenges and time required to assemble these files, proteomics has struggled to expand beyond the confines of a few model organisms. When considering post‐translational modifications that may or may not be present on a specific peptide sequence, these factors inevitably compound. A study on how mangos continue to ripen on the shelf may not be the first thing you'd think of as proof of a scientific discipline shedding historic limitations. However, Bautiste‐Valle et al., may be just that. These authors present a quantitative comparison of both peptide and glycopeptide alterations through the complexity of the fruit ripening process and in this we see the present state of a field that no longer needs to wait on genomics to obtain deep mechanistic insights.
Two novel approaches for solving the contradiction between efficient penetration and low recoil for the low‐velocity penetrator
Authors: Xu Cheng , Feng Jingkai , Liu Jinguo , Tian Yuanzheng , Lu Da 
Published: March 2024

AbstractThe low‐velocity penetrator (LVP) is a planetary penetration device that can drive itself to a target depth through its internal periodic impacts. When LVP generates impact energy, it inevitably produces a recoil that can only be counteracted by friction with the soil, if there is no other auxiliary device. Unfortunately, LVP is extraordinarily sensitive to the recoil during the initial stage since the small contact area with the soil results in minor friction between them. Significantly, once the recoil exceeds the friction, LVP cannot work properly and may even retreat, inducing mission failure. In this paper, we develop an optimized LVP with an auxiliary device for lower recoil and higher performance. Specifically, we establish a dynamic model to analyze the single‐cycle motion of LVP and provide essential support for its optimization and design. Meanwhile, an integration method is proposed to calculate the friction between LVP and the soil reasonably and accurately. On the basis of these, we obtain the optimal mass and stiffness parameters of LVP that meet both high penetration efficiency and low recoil. Furthermore, only relying on the parameter optimization is insufficient to eliminate the recoil, and an auxiliary penetration scheme is proposed to provide an external force counteracting the recoil until LVP arrives at a certain depth. Through multiple comparative penetration experiments, we validate the effectiveness of our approaches in promoting penetration ability, stability, and restraining the recoil of LVP. This work provides two novel approaches for solving the contradiction of efficient penetration while reducing the recoil for LVP.
High‐Loading Lithium‐Sulfur Batteries with Solvent‐Free Dry‐Electrode Processing
Authors: Sul Hyunki , Lee Dongsoo , Manthiram Arumugam 
Published: March 2024

AbstractLithium‐sulfur (Li‐S) batteries, with their high energy density, nontoxicity, and the natural abundance of sulfur, hold immense potential as the next‐generation energy storage technology. To maximize the actual energy density of the Li‐S batteries for practical applications, it is crucial to escalate the areal capacity of the sulfur cathode by fabricating an electrode with high sulfur loading. Herein, ultra‐high sulfur loading (up to 12 mg cm−2) cathodes are fabricated through an industrially viable and sustainable solvent‐free dry‐processing method that utilizes a polytetrafluoroethylene binder fibrillation. Due to its low porosity cathode architecture formed by the binder fibrillation process, the dry‐processed electrodes exhibit a relatively lower initial capacity compared to the slurry‐processed electrode. However, its mechanical stability is well maintained throughout the cycling without the formation of electrode cracking, demonstrating significantly superior cycling stability. Additionally, through the optimization of the dry‐processing, a single‐layer pouch cell with a loading of 9 mg cm−2 and a novel multi‐layer pouch cell that uses an aluminum mesh as its current collector with a total loading of 14 mg cm−2 are introduced. To address the reduced initial capacity of dry‐processed electrodes, strategies such as incorporating electrocatalysts or employing prelithiated active materials are suggested.
Pleurotomariida (Gastropoda) from the upper Anisian platform carbonates of the Dolomites (Southern Alps, Italy): systematics, palaeobiogeography and Triassic recovery
Authors: Monari Stefano , Dellantonio Elio 
Published: March 2024

AbstractA very rich gastropod fauna from the upper Anisian (Nevadites secedensis Zone) platform carbonates of the Dolomites, represented by more than 200 species, was collected over recent decades. Its study contributes to a better understanding of the dynamics of the recovery after the end‐Permian mass extinction. This paper deals with the Pleurotomariida. A total of 35 species, 22 genera and 9 families have been identified. Of these, 12 species and 7 genera are new, namely Rufilla wilckensi sp. nov., Rufilla giacomellii sp. nov., Viezzenella ruvida gen. et sp. nov., Temnotropis maestroettorei sp. nov., Cancellotomaria boninsegnai sp. nov., Stuorella crenulata sp. nov., Codinella? fontanai sp. nov., Fiacconella pericincta gen. et sp. nov., Fiemmespira gen. nov., Texturaspira gen. nov., Nodocingulum ogilvieae sp. nov., Dimorphotomaria fassaensis gen. et sp. nov., Moenaspira crassa gen. et sp. nov. and Predazzella elongata gen. et sp. nov. Comparison with the gastropod fauna of the St Cassian Formation indicates that, from the late Anisian to the Carnian, in the Dolomites the richness of the Pleurotomariida increased by 54% at species level, 26% at genus level and 22% at family level. A comprehensive palaeobiogeographical analysis highlights a very high degree of endemism: 90% of the species are exclusive to single palaeogeographical units. This suggests that species diversification at a strict local scale was a major feature of the Middle Triassic phase of recovery of the Pleurotomariida. Seemingly, the non‐planktotrophic development of this group combined with a patchy resurgence of the carbonate platforms played an important role in hampering dispersal.
PRODEC for human systems integration of increasingly autonomous systems
Authors: Boy Guy André , Masson Dimitri , Durnerin Élise , Morel Chloé 
Published: March 2024

AbstractThe purpose of the PRODEC scenario‐based design method is the incremental cross‐fertilization and refinement of procedural scenarios and declarative configurations. It uses virtual prototypes of the developed systems (mainly life‐critical systems) to conduct human‐in‐the‐loop simulations (HITLSs). Based on human systems integration (HSI) principles and criteria, as well as expertise and experience in the domain at stake, this HSI approach grounded in virtual environments requires a clear definition of physical and cognitive tangibility metrics to assess the distance between virtual and tangible (grasp) dimensions of the system being developed when it is put to work. PRODEC considers human and machine systems described in terms of structures and functions incrementally designed using procedural scenarios (i.e., stories) in task and activity networks, which provide life to declarative configurations (i.e., system's functions and structures). This active modeling and simulation process enables the discovery of emergent structures and functions of the system being developed when it is virtually operated. PRODEC's use is illustrated in an example. We discuss the use of PRODEC and its results as to how they can be used with digital twins.
Elevated middle cerebral artery peak systolic velocity and risk of death in donor twin affected by twin–twin transfusion syndrome but not twin anemia–polycythemia sequence
Authors: Espinoza J. , Agarwal N. , Johnson A. , Hernandez‐Andrade E. , Backley S. , Papanna R. , Bergh E. P. 
Published: March 2024

ABSTRACTObjectivesTo determine the association between elevated (> 1.5 multiples of the median (MoM)) middle cerebral artery (MCA) peak systolic velocity (PSV) and fetal demise of the donor twin in pregnancies complicated by twin–twin transfusion syndrome (TTTS) in the absence of twin anemia–polycythemia sequence (TAPS). Secondary objectives were to evaluate if donor or recipient MCA‐PSV is associated with a risk for their corresponding fetal death, and to compare the proportion of donor fetuses with low MCA pulsatility index (PI) among donor twins with high MCA‐PSV and those with normal MCA‐PSV to evaluate the contribution of blood‐flow redistribution to the fetal brain in donor twins with high MCA‐PSV.MethodsThis prospective cohort study included TTTS cases that underwent laser surgery between 2011 and 2022 at a single center. TAPS cases were excluded from the study. Multivariable and Poisson regression analysis were performed to explore the association between isolated elevated donor MCA‐PSV and fetal demise, adjusted for TTTS stage, selective fetal growth restriction (sFGR) and other confounders.ResultsOf 660 TTTS cases, donor MCA‐PSV was not recorded in 48 (7.3%) cases. Of the remaining 612 patients, nine (1.5%) were lost to follow‐up and 96 TAPS cases were excluded; thus, 507 cases were included in the study. High donor MCA‐PSV was seen in 6.5% (33/507) of cases and was an independent risk factor for donor fetal demise (adjusted relative risk (aRR), 4.52 (95% CI, 2.72–7.50)), after adjusting for confounders. Regression analysis restricted to each Quintero TTTS stage demonstrated that high donor MCA‐PSV was an independent risk factor for fetal demise of the donor in Quintero Stage II (aRR, 14.21 (95% CI, 1.09–186.2)) and Quintero Stage III (aRR, 3.41 (95% CI, 1.82–6.41)). Donor MCA‐PSV in MoM was associated with fetal demise of the donor (area under the receiver‐operating‐characteristics curve (AUC), 0.69; P < 0.001), but recipient MCA‐PSV in MoM was not associated with fetal demise of the recipient (AUC, 0.54; P = 0.44). A higher proportion of donor twins in the group with high MCA‐PSV had a low MCA‐PI compared to the group with normal MCA‐PSV (33.3% vs 15.5%; P = 0.016).ConclusionsElevated donor MCA‐PSV without TAPS prior to laser surgery for TTTS is associated with a 4‐fold increased risk for donor fetal demise, adjusted for sFGR, TTTS stage and other confounders. Doppler evaluation of donor MCA‐PSV prior to laser surgery may help stratify TTTS staging to evaluate the risk of donor fetal demise. © 2024 International Society of Ultrasound in Obstetrics and Gynecology.
Mechanical and cytotoxic analysis of cutlery developed from phenol‐formaldehyde modified soy‐jute composite
Authors: Behera Ajaya Kumar , Pattnaik Shruti Swaroop , Mohanty Chirasmayee , Srivastav Rohit , Pradhan Jyotsnarani 
Published: March 2024

AbstractThe need of the hour is for the creation of natural fiber‐based, biodegradable cutlery in order to protect our planet from pollution caused by plastic. Soy resin creates a hard eco‐friendly/biodegradable composite when combined with phenol‐formaldehyde/resole and a natural fiber like jute. In this experiment, soy and other ingredients are combined with various weight percentages of resoles. Jute‐modified soy composites are characterized through Fourier transform infra‐red spectroscopy, mechanical testing and found maximum tensile strength of 46.62 MPa. After 8 weeks of microbial degradation testing on the generated composites, it is discovered that the mechanically optimized composite lost only 17.7% of its initial weight. Cutlery pieces are molded using the jute‐soy/jute‐resole modified soy composition, and cytotoxicity testing has shown that they are non‐toxic. Because they are non‐toxic and biodegradable, these composites can be used as a substitute to non‐biodegradable plastic in a range of industries.
Functionalization of a liquid natural rubber by iron‐mediated radical chloro‐nitration and its thermal decomposition
Authors: Doan Khai Minh , Tran Trung Bao , Kim Hop Dinh , Dam Hieu Quang , Nguyen Tuan Duy , Ly Vuong Quoc 
Published: March 2024

AbstractThis study presents the functionalization of liquid natural rubber (LNR) by iron‐mediated radical chloro‐nitration over the LNR backbone, resulting in a chloro‐nitro compound of liquid natural rubber (Cl‐N‐LNR). The chloro‐nitration was prepared by a reaction of LNR with iron(III) nitrate nonahydrate and iron(III) chloride in an organic solvent. The structure of the obtained product was confirmed by using Fourier‐transform infrared spectroscopy (FTIR), proton nuclear magnetic resonance (1H NMR), and carbon‐13 nuclear magnetic resonance (13C NMR), which showed the existence of chloro‐nitro groups in the Cl‐N‐LNR chain. The degree of functionalization with a nitro group is 13.4% mol units of Cl‐N‐LNR. The thermal degradation was determined by the thermogravimetric analysis (TGA) method. As a result, the kinetic parameters for the degradation of Cl‐N‐LNR were calculated in the range from 40 to 330 °C. The half‐life of Cl‐N‐LNR was found to be about 33.0 years.
Synthesis of materials from agricultural wastes combined with Fe3O4for methylene blue adsorption and application to treat organic pollutants in water samples
Authors: Thi Hoang Anh , Phuc Le Thien , Van Trong Nguyen , Thuy Tran Thi Thanh 
Published: March 2024

AbstractThis study presents the adsorption process of methylene blue and other organic pigments in water samples using synthetic materials derived from agricultural waste combined with Fe3O4. The properties of the materials were determined through Fourier transform infrared spectroscopy, scanning electron microscopy, X‐ray diffraction, and nitrogen adsorption‐desorption isotherm. The result shows the successful association of Fe3O4on materials prepared from agriculture with a surface area = 3.594 m2g−1and a pore size of 49.713 nm. The optimal factors of methylene blue removal process, such as pH, mass, initial concentration, time, and shaking speed, were also investigated, respectively. The maximum adsorption capacity of the material is 268.64 mg g−1, with an adsorption efficiency of 98.84%. The research method was applied to analyze and evaluate the materials' adsorption capacity in the southern provinces of Vietnam water samples.
Synthesis, characterization and anticancer activity of Ni(II), Cu(II), Pd(II) and Au(III) complexes derived from novel Mannich base
Authors: Manhee Tamara Q. , Alabdali Ammar J. 
Published: March 2024

AbstractNew four complexes of Ni(II), Cu(II), Pd(II), and Au(III) were derived from the tridentate ligand 3‐((3‐(4‐hydroxyphenyl)‐5‐mercapto‐4H‐1,2,4‐triazol‐4‐yl)(3‐oxobutyl)amino)naphtho[2,3‐b]furan‐2(3H)‐one (L), which synthesized using condensation reaction of formaldehyde, acetone, and secondary amine (Mannich reaction). The secondary amine is a heterocyclic compound possesses two rings, naphthafuran and triazole, both rings prepared through intermolecular cyclization reactions. Considering that naphthafuran‐2‐one derived from α‐amino nitrile. The α‐amino nitrile compound contains the other triazole ring which illustrated to the structure through successive steps. The compounds were characterized using elemental analysis (C.H.N.S), FT‐IR, ultraviolet–visble spectroscopy, thermal gravimetric analysis (TGA), flame atomic absorption, molar conductivity, and magnetic susceptibility measurements. Accordingly, the probable geometries of the complexes were suggested as square planner, and they have electrolytic nature. Thus, chemical formula; [NiLCl]Cl·6H2O, [CuLCl]Cl·2H2O, [PdLCl]Cl·2H2O, and [AuLCl]Cl2·3H2O. Cytotoxic effect was studied on brain cancer cell line (AMJM cell line) at different concentrations for L and complexes. The results showed that gold(III) complex has the highest cytotoxicity among all compounds.
Design, in silico studies, synthesis, and in vitro anticancer assessment of new naphthylidene isoxazolidinedione derivatives
Authors: Upadhyay Neha , Tilekar Kalpana , Oak Aditi , Pokrovsky Vadim S. , Subramanian Chelakara Ramaa 
Published: March 2024

AbstractCancer is the most destructive and fatal disease, representing an urgent medical challenge to the world. The discovery of a new anticancer candidate may help reduce or eliminate this alarming disease to a greater extent. On similar lines, in silico research was carried out on novel naphthylidene isoxazolidinedione derivatives that were logically conceived, synthesized, purified, and structurally characterized. In vitro biological evaluation revealed the most active compound 4d with an inhibitory concentration of 42.87 µm against K562 and 47.42 µm on A549 cells. The anticancer activity of this naphthylidene isoxazolidinedione derivative was evident by cell cycle and apoptosis assays, which showed arrest of the G2/M phase (65.6%) of the K562 cells and induction of apoptosis with 21.47% apoptotic cells as compared to 0.2% of untreated cells, respectively.
Potential oxidoreductases inhibitors from medicinal plants‐based phytochemicals: A review
Authors: Gomes Tarsila , Alejandro Gracebio , Thao Tran Thi Phuong , Vieira Amandio Vincent 
Published: March 2024

AbstractOxidoreductases (ORases) are enzymes that catalyze oxidation and reduction reactions in cells or extracellular compartments of the body. Genetic mutations and other factors that affect ORase activity have been implicated in a range of diseases, especially inherited metabolic disorders. Aldose reductase, sorbitol dehydrogenase, xanthine oxidoreductase are the ORases with relevance to diabetes pathology. Herein, the strategies for screening modulators of ORase activities, and medicinal plants whose phytochemicals have the potential to influence ORase activity, are described. The overall goal is to test and identify natural products and other compounds that may have a therapeutic benefit in relation to hyperglycemia and diabetes.
Cell-specific IL-1R1 regulates the regional heterogeneity of microglial displacement of GABAergic synapses and motor learning ability
Authors: You Yi , An Da-dao , Wan Yu-shan , Zheng Bai-xiu , Dai Hai-bin , Zhang She-hong , Zhang Xiang-nan , Wang Rong-rong , Shi Peng , Jin Mingjuan , Wang Yi , Jiang Lei , Chen Zhong , Hu Wei-Wei 
Published: March 2024

AbstractMicroglia regulate synaptic function in various ways, including the microglial displacement of the surrounding GABAergic synapses, which provides important neuroprotection from certain diseases. However, the physiological role and underlying mechanisms of microglial synaptic displacement remain unclear. In this study, we observed that microglia exhibited heterogeneity during the displacement of GABAergic synapses surrounding neuronal soma in different cortical regions under physiological conditions. Through three-dimensional reconstruction, in vitro co-culture, two-photon calcium imaging, and local field potentials recording, we found that IL-1β negatively modulated microglial synaptic displacement to coordinate regional heterogeneity in the motor cortex, which impacted the homeostasis of the neural network and improved motor learning ability. We used the Cre-Loxp system and found that IL-1R1 on glutamatergic neurons, rather than that on microglia or GABAergic neurons, mediated the negative effect of IL-1β on synaptic displacement. This study demonstrates that IL-1β is critical for the regional heterogeneity of synaptic displacement by coordinating different actions of neurons and microglia via IL-1R1, which impacts both neural network homeostasis and motor learning ability. It provides a theoretical basis for elucidating the physiological role and mechanism of microglial displacement of GABAergic synapses.