bluuebunny/crossref_metadata_2025_split huggingface dataset:
Salivary gland cancer and risk of subsequent skin cancer
Authors: Spitz Margaret R. , Sider Joanne G. , Newell Guy R. 
Published: February 2007

AbstractThere are epidemiologic similarities between salivary and skin neoplasms that could be attributed to exposure to ultraviolet radiation. To explore further the etiologic parallels between these two types of cancer, we studied the multiple primary association between salivary gland cancer with that of other cancers known to be induced by ultraviolet light exposure, using data from the SEER program for 1973‐1984. Because nonmelanoma skin cancers other than cancers of the lip are not routinely reported to the SEER registries, we specifically evaluated the associations with melanoma and lip cancers. Expected numbers of subsequent primaries (melanoma and lip) for the 904 white men and 784 white women with an initial salivary gland cancer were computed from incidence rates using the Connecticut Tumor Registry. There were significantly increased risks for subsequent lip cancer among men (RR = 8.7) and for melanoma among women (RR = 7.1). Among men there was also a significant association between an initial lip cancer and risk of subsequent salivary gland cancer (RR = 12.7). These observations, together with reported increases in incidence of these tumors, suggest a common etiology, which could partly be explained because of exposure to ultraviolet radiation.
Actinomycotic granuloma masquerading as an infraorbital nerve neoplasm
Authors: Har‐Ei Gady , Prager David A. , De Soto La Paix Fidelina , Nash Michael 
Published: February 2007

AbstractActinomycotic infections of the head and neck region are rare and frequently present a confusing clinical picture. We document a case of actinomycosis that simulated a neoplasm of the infraorbital nerve, both clinically and surgically. To the best of our knowledge, this is the first report of actinomycosis involving this nerve. Correct diagnosis of actinomycotic infection in the head and neck relies most heavily on clinical suspicion. It is, therefore, imperative for the head and neck surgeon to be familiar with the etiology of this infection and its various modes of presentation as well as its appropriate management.
Clinicostatistical study of lower lip mucoceles
Authors: Yamasoba Tatsuya , Tayama Nirou , Syoji Minoru , Fukuta Masahiro 
Published: February 2007

AbstractWe reviewed 70 patients with lower lip mucoceles for patient characteristics, clinical features, and histopathologic findings. These cases represented approximately 75% of oral mucoceles seen in the Department of Otolaryngology, Takeda General Hospital, between February 1985 and July 1988. Patients were divided almost equally between males and females, with ages ranging from 2 to 63 years, with the highest incidence of lesions occurring in the second decade. Duration of the lesions varied greatly from a few days to 3 years, with no correlation to size. The most commonly affected site was opposite the upper lateral incisor, with the incidence divided almost equally between right and left side. Of 70 biopsies, 68 were mucous extravasation cysts and 2 were mucous retention cysts. Surgical excision was the treatment of choice, with recurrence of the lesion in only 2 cases.
Risk of hypoparathyroidism after surgery for carcinoma of the thyroid
Authors: Rao Raja S. , Jog Vinayak B. , Baluja Chanda A. , Damle Shrikrishna R. 
Published: February 2007

AbstractThe reported incidence of postoperative hypoparathyroidism varies from 3% to 32%, and many surgeons are reluctant to perform a total thyroidectomy because of the risk of permanent damage to the parathyroid glands. We prospectively studied three groups of patients for evidence of acute parathyroid damage: group A consisted of 29 patients with total thyroidectomies; group B, 21 controls with partial thyroidectomies; and group C, 29 patients with total thyroidectomies that had been performed several months to years earlier. Functional status of the glands was measured by serum parathormone, calcium, and phosphorus levels. Although these levels fell postoperatively, they remained within normal limits. None of the long‐term follow‐up patients (group C) was found to have hypoparathyroidism, leading us to conclude that this risk may be overstated in the literature.
Blindness following bilateral radical neck dissection
Authors: Marks Steven C. , Jaques Darrell A. , Hirata Richard M. , Saunders John R. 
Published: February 2007

AbstractBlindness after bilateral radical neck dissection is a rare complication. A recent patient, who suffered total blindness after simultaneous bilateral radical neck dissection, is the fifth case reported. It is, however, the first with pathological study of the optic tracts. Detailed microscopic examination revealed bilateral intraorbital hemorrhagic optic nerve infarction without evidence of embolization or ophthalmic artery occlusion. The probable etiology of this event is an episode of prolonged hypotension. An additional etiologic factor may be increased resistance to blood flow caused by venous hypertension, resulting from bilateral internal jugular vein ligation.
Extramedullary plasmacytoma of the parotid
Authors: Rothfield Robert E. , Johnson Jonas T. , Stavrides Alexander 
Published: February 2007

AbstractPrimary extramedullary plasmacytoma (PEMP) is a tumor of atypical neoplastic cells that arise outside the bone marrow in patients without clinical evidence of existing multiple myeloma. These rare tumors, which can occur in virtually any part of the body, have shown a clear predilection for the head and neck. Yet despite the fact that nearly 80% of these tumors can be found in the upper respiratory tract or oral cavity, their involvement in the parotid is singularly rare. The clinical behavior of this tumor is not yet well‐defined, and local recurrence, distant metastasis, and transformation to multiple myeloma have all been reported. Since the first case of parotid PEMP was reported in 1965, 8 additional cases have been noted in the literature. This is the 9th case of PEMP of the parotid to be described.
Metastatic involvement of the cavernous sinus from primary pharyngolaryngeal tumors
Authors: Traserra Jose , Comas Jaime , Conde Cesareo , Cuchi Asuncion , Cardesa Antonio 
Published: February 2007

AbstractThe cavernous sinus is an unusual site for metastases from tumors of the larynx and pharynx. In postmortem studies of patients with cancers of the larynx, hypopharynx, and other sites, cavernous sinus metastases have been detected in very few cases. We present 3 cases of metastatic cavernous sinus disease. Despite the lack of pathologic diagnosis by biopsy, we feel that the clinical presentation combined with computed tomography provides an accurate diagnosis.
Modified radical neck dissection in cancer of the mouth, pharynx, and larynx
Authors: Khafif Rene A. , Gelbfish Gary A. , Asase Danilo K. , Tepper Patrick , Attie Joseph N. 
Published: February 2007

AbstractA retrospective analysis of 390 determinate radical neck dissections (RND) performed for cancers of the mouth, pharynx, and larynx was carried out. There were 75 patients (19%) who had a modified RND. These were separately analyzed and the outcome was compared to those who had a standard total RND. Our goal was to assess the effectiveness of modified RND in controlling disease in the neck, and to identify its impact on survival and quality of life. Overall neck recurrence rate in the entire modified RND group was 28%, 35% in the partial RND, and 25% in the comprehensive modified RND. Neck recurrence rate was no worse in the comprehensive modified RND for NO and N1 cases, but increased significantly (as compared to the group of patients with standard RND) in the N2 and N3 cases (52% vs. 33%) Treatment of neck recurrences following modified RND was primarily by surgery, with a 48% 3‐year disease‐free survival. Overall survival was the same for modified RND (68%) and for standard total RND (63%). This was true for all N stages individually. The morbidity of standard total RND is discussed and the goals of modified RND are analyzed. Definitions and a standardized nomenclature for the various types of modified RND are suggested for uniformity of reporting. From the Department of Surgery, Divison of Head and Neck Surgery, Maimonides Medical Center, Brooklyn, New York.
Innervation of the trapezius muscle: A study in patients undergoing neck dissections
Authors: Soo K. C. , Guiloff R. J. , Oh A. , Rovere G. Querci Della , Westbury G. 
Published: February 2007

AbstractTwenty‐four patients with surgical section of the accessory nerve and/or its cervical contribution(s) were examined from 1 to 156 months after surgery, and compared to twenty controls. Thirteen patients had a classical neck dissection; seven had the whole length of the accessory nerve preserved but not the cervical plexus contributions. Four had the upper half of the accessory nerve sectioned, but with preservation of both the lower half and its cervical contributions. Clinical and electrophysiological studies of the three portions of the trapezius suggested the existence of an undescribed motor nerve supply to the trapezius and of a motor input from the cervical plexus contributions via the accessory nerve. The former is also supported by an anatomical study.
Metallic clips as a time/cost saving adjunct to head and neck surgery
Authors: Davidson Terence M. , Olson Terry S. 
Published: February 2007

AbstractMetal surgical clips are commonly used in head and neck surgery today. In this study of 10 patients, 69 vessels in the neck were ligated with tantalum clips and 68 vessels were ligated with silk ties. The times for cutting and ligating each vessel were recorded and the results show a 31‐second timesavings by clipping the vessel as opposed to tying. The use of metal clips on vessels is found to be both safe and effective, while reducing operative time.
Anatomic study of the otic ganglion in humans
Authors: Roitman Roman , Talmi Yoav P. , Finkelstein Yehuda , Sadov Rima , Zohar Yuval 
Published: February 2007

AbstractThe presentation in the literature of the anatomy of the human otic ganglion (OG) has not varied much over the past three quarters of a century, Precise, similar descriptions of its size, color, shape, and relation with neighboring structures are portrayed in numerous textbooks and articles. We have carried out a study of the OG in 30 infratemporal fossae of 15 cadavers. Otic ganglia resembling the classic description were found in less than 60% of the cases. In 13%, some thickening could be seen adjacent to the mandibular nerve and in 27%, no definite structure could be observed. Except for a fleeting mention of this occurrence in a textbook from 1927, substantiated by personal communication with an authority in the field, we could find no record of the possible absence of this structure in the available literature. We describe our findings and stress the apparent anatomic variability of the OG. The pertinent literature is reviewed.
Anterior neopharyngeal diverticulum following laryngectomy
Authors: Sobol Steven M. , Prince Karen , Cronin David 
Published: February 2007

AbstractWhile less common than stricture, recurrent neoplasm, and neuromuscular dysfunction, neopharyngeal diveritculum must be considered in the differential diagnosis of postlaryngectomy dysphagia. Symptoms of difficulty clearing the neopharynx during and after a swallow, with regurgitation of undigested material, should alert the clinician to this possibility. Experience with 3 postlaryngectomy patients with anterior neopharyngeal divericulae serve as the springboard for discussion of the clinical spectrum, radiologic features, contributory pathophysiologic factors, and therapeutic options concerning this condition. Surgical indications, approaches, and potential hazards are reviewed.
Development of surgical quality‐control mechanisms in large‐scale prospective trials: Head and neck intergroup report
Authors: Jacobs John R. , Pajak Thomas F. , Weymuller Ernest , Sessions Donald , Schuller David E. 
Published: February 2007

AbstractOne of the current national prospective clinical trials of the Head and Neck Intergroup explores the usage of chemotherapy in advanced operable head and neck cancer patients. The experimental arm consists of the addition of 3 courses of cisplatin‐containing chemotherapy to standard treatment defined as surgery followed by postoperative radiotherapy. In the design of the study it is necessary to define not only the extent of the surgery performed for each eligible lesion, but also to insure uniformity of surgery performed between surgeons and institutions. This will hopefully insure that any variation between the 2 arms of the study represent the effect of the chemotherapy. The procedure to obtain and confirm uniformity of surgery is multifaceted. It is, however, fundamentally based upon the current TNM staging system and therefore has intrinsic limitations.
Modifications of the mandibular swing for preservation of occlusion and function
Authors: Clayman Gary L. , Adams George L. 
Published: February 2007

AbstractThe mandibular swing, or midline mandibular osteotomy with lateral mandibular displacement, provides excellent exposure equivalent to that obtained by composite resections of the mandible while minimizing cosmetic and functional disability and reducing the complexity of reconstruction. This procedure is most commonly described from an oncologic standpoint. Modifications of this procedure, performed on patients with adequate anterior mandibular height, provide access to lesions of the skull base, as well as benign lesions of the parapharyngeal space. Minor modifications of the midline mandibular osteotomy, as well as preservation of anterior mandibular dentition, provide these patients with immediate restitution of interocclusal anatomy and function.
Cranial nerve injuries following carotid endarterectomy: An analysis of 336 procedures
Authors: Maniglia Anthony J. , Han D. Peter 
Published: February 2007

AbstractCranial nerve injuries may result from carotid endarterectomy. From January 1984 to December 1987, a total of 336 carotid endarterectomies were performed at University Hospitals of Cleveland and Cleveland Veterans Administration Hospital. Forty‐five cranial nerve injuries were documented (13.5%). Twenty patients (6%) had documented unilateral vocal cord paralysis, 16 (4.8%) had hypoglossal injuries, 8 (2.4%) had facial nerve paresis, and 1 (0.3%) had an injury to the spinal accessory nerve. Although most injuries were due to either retraction or edema of cranial nerves, long‐term follow‐up regarding recovery of function is very important. We feel that proper clinical evaluation of these patients should be routinely done preoperatively in order to document possible preexisting cranial nerve deficits. Postoperatively, if symptoms of possible cranial nerve abnormalities occur, these patients should have a thorough head and neck evaluation in order to identify possible lesions and institute further treatment to improve their quality of life.
Characterization, quantification, and potential clinical value of the epidermal growth factor receptor in head and neck squamous cell carcinomas
Authors: Santini José , Formento Jean‐Louis , Francoual Mireille , Milano Gérard , Schneider Maurice , Dassonville Olivier , Demard François 
Published: February 2007

AbstractEpidermal growth factor (EGF) stimulates the growth of several types of epithelial tissues and possesses a strong mitogenic activity that is mediated through its cell surface receptor (EGFR). The aim of this study was to characterize EGFR and measure its levels in head and neck tumors biopsies (70 patients); use of a simplified competition technique with a radiolabeled ligand allowed evaluation of functional EGFR. Five samples (4 tumors and 1 control) were used to characterize EGF binding. Graphic representation identified a single family of binding sites. Kd values revealed high affinity for EGF binding: mean Kd, 0.156/pm 0.108 nM (0.095‐0.347 nM). EGF‐binding characteristics (Kd) were similar in nontumoral tissue samples (controls) and in tumor material. In 59 of 60 cases, EGFR levels were higher in the tumor than in the corresponding controls. A significant correlation was found between EGFR levels and tumor size and stage. Controls exhibited a trend toward higher EGFR levels in elevated sizes and stages. According to a cutoff EGFR value of 100 fmol/mg protein, which separated all controls from tumors, EGFR‐positive tumors (>100 fmol/mg protein) had a greater probability of complete response to chemotherapy than EGFR‐negative tumors; other tumor characteristics, such as the degree of tumoral differentiation, tumor size, or stage, were unable to operate such a discrimination in the response to chemotherapy. EGFR may thus be an interesting biological marker for head and neck cancer.
Scintigraphic localization of ectopic parathyroid lesions with thallium‐201
Authors: Moisa Idel I. , Silver Carl E. 
Published: February 2007

AbstractSix consecutive patients with ectopic parathyroid lesions were studied by preoperative thallium‐technetium scintigraphy. Ectopic lesions were accurately localized in 5 of 6 patients. Four of five lesions deep in the superior mediastinum, and 1 in the superior carotid sheath, were correctly identified. Ectopic lesions in 4 of 5 patients, who had previously undergone unsuccessful exploration, were correctly localized. In 1 previously unoperated patient, a mediastinal lesion was identified by preoperative scintigraphy. In 2 patients, deep mediastinal exploration via manubriotomy was successfully conducted without confirmation by “invasive” intravascular procedures. There were no false‐positive studies. Lesions identified weighed from 185 mg to 9 g and were from 1.1 to 3.0 cm in size. Scintigraphy is particularly effective for demonstration of ectopic parathyroid tissue, because the absence of thyroid tissue in the mediastinum or superior cervical region permits appreciation of areas of abnormal thallium uptake unobscured by uptake in adjacent thyroid tissue. We conclude that ectopic parathyroid tissue may be accurately identified by thallium‐technetium scintigraphy without confirmation by invasive intravascular studies.
New approach to the nasopharynx: The maxillary swing approach
Authors: Wei William L. , Lam Kam H. , Sham Jonathan S. T. 
Published: February 2007

AbstractA new approach to expose the nasopharynx and the parana sopharyngeal space is described. The maxilla, severed from its bony connections, is swung laterally to provide exposure of the nasopharynx. Tumors in the nasopharynx and the paranasopha ryngeal space can be adequately resected and tubings for after loading brachytherapy can be positioned accurately during surgery. The blood supply of the maxilla is from the attached cheek flap and masseter muscle. Three illustrative cases are presented. The wounds in all of them healed primarily with minimal morbidity. The only disadvantage is the development of mild trismus, which responded to conservative treatment.
Variables predicting oral mucosal lesions in allogenic bone marrow recipients
Authors: Mattsson Torsten , Heimdahl Anders , Dahllof Goran , Nilsson Bo , Lonnqvist Berit , Ringdén Olle 
Published: February 2007

AbstractOne hundred and forty‐eight (72%) of 205 allogenic bone marrow transplant recipients developed mucosal lesions in the oral cavity during the aplastic period after transplantation. Lesions were most frequent 8 to 9 days after transplantation. Factors that correlated with the development of mucosal lesions after univariate and multivariate analysis were a marrow cell dose of < 3 × 108cells/kg body weight, (p< 0.0001), prolonged aplastic period (white blood cell count < 0.2 × 109) cell/l during more than 14 days (p< 0.005), herpes simplex virus‐1 seropositivity of the recipient (p< 0.01), and conditioning with total body irradiation (p< 0.02).
Branchial cleft cyst manifesting as hypoglossal nerve palsy
Authors: Gatot Albert , Tovi Ferit , Fliss Dan M. , Yanai‐Inbar Ilana 
Published: February 2007

AbstractHypoglossal nerve palsy occurred in 2 patients with infected second branchial arch cleft cyst. This very unusual complication of the congenital anomaly has been related to the mechanical compression of the mass. Histologic features of the perineural coat were also suggestive for this etio‐pathogenesis.
Fundamentals of expanded tissue
Authors: Baker Shan R. 
Published: February 2007

AbstractThe relatively recent advent of tissue expansion for medical purposes precludes the availability of extensive knowledge concerning the physiologic and histologic changes that occur during controlled expansion of the skin. This paper reviews the basic science and clinical research that has been conducted to investigate the changes and summarizes the findings. It can be concluded that flaps harvested from skin previously expanded have an improved survival rate compared to similar flaps developed in nonexpanded skin. Increased vascularity to either the skin, the capsule that forms around the expander, or both probably in some way accounts for the improved survival. Controlled expansion of the skin results in the creation of additional new skin at the expense of thinning the dermis and subcutis. This thinning is associated with an overall decrease in tensile strength of the expanded skin. The increase in surface area gained from skin expansion probably varies according to the type of skin expanded and the underlying tissues that serve as a foundation for the expander.
Speech patterns following partial glossectomy for small tumors of the tongue
Authors: Heller Keith S. , Levy Joan , Sciubba James J. 
Published: February 2007

AbstractTo determine the type and extent of speech impairment to be expected following partial glossectomy, pre‐ and postoperative speech evaluations were performed on 10 patients undergoing surgery for carcinomas of the mobile tongue less than 3 cm in size. In addition, audiotapes of standardized speech samples were made at each evaluation. Preoperative speech evaluation revealed normal rates of verbal diadochokinesis without distortion in all 10 patients. Phonologic analysis was also normal in 9 of these patients. Postoperative evaluation revealed normal rates of verbal diadochokinesis in 6 patients and mild lingual distortion in 4. At 3 weeks postoperatively 1 patient had sibilant distortion and 1 patient overall slurring of speech. Evaluation of both of these patients at 6 months revealed that speech had returned to normal. Blinded comparison of the pre‐ and postoperative audiotapes revealed no change in 8 patients. In 2 patients the early postoperative tape was thought to “sound different” but the final postoperative tapes in all patients were judged to be normal. This study demonstrates that partial glossectomy for early carcinomas of the tongue can be performed with minimal, if any, permanent speech impairment.
Increased intracranial pressure as a complication of unilateral radical neck dissection in a patient with congenital absence of the transverse sinus
Authors: Lydiatt Daniel D. , Ogren Frederic P. , Lydiatt William M. , Hahn Francis J. 
Published: February 2007

AbstractWe report a patient with increased intracranial pressure occurring after unilateral neck dissection. Subsequent vascular studies reveal a hypoplastic contralateral transverse sinus drainage and occlusion of the ipsilateral jugular bulb. We review the literature on the etiology of this vascular malformation and conclude that vascular anomalies of the venous drainage of the head be considered whenever postoperative signs of increased intracranial pressure occur after unilateral radical neck dissection.
Nodular fasciitis of the oral mucosa: Light and electron microscopy study
Authors: Bodner Lipa , Dayan Dan 
Published: February 2007

AbstractNodular fasciitis of the oral mucosa is a rare lesion. The present article describes an additional case and discusses the difficulties in the histologic diagnosis. The final diagnosis is based on immunohistochemistry and electron microscopic morphology. Nodular fasciitis should be considered in the differential diagnosis of swellings in the oral mucosa.