bluuebunny/crossref_metadata_2025_split huggingface dataset:
BUTUGOL METAMORPHIC COMPLEX – EXOTIC PRECAMBRIAN BLOCK IN THE STRUCTURE OF THE BASEMENT OF THE TUVA-MONGOLIAN MICROCONTINENT (EASTERN SAYAN)
Authors: Shkolnik S. I. , Belyaev V. A. , Letnikova E. F. , Demonterova E. I. , Bryansky N. V. , Kolesov K. K. , Ivanov A. V. 
Published: April 2024

Isotope-geochronological and geochemical data and age of the metamorphic rock of the Butugol metamorphic Complex, located in the eastern part of the Tuva-Mongolian microcontinent of the CAOB, have been obtained. It has been established that the gneisses protolith is, in one case, volcanic rocks with an age of 1009 ± 8 Ma, in the other case, potassium meta-sedimentary rocks accumulating in continental marginal basins. The formation of the protolith of the metavolcanogenic rocks of this complex took place at the turn of the Meso- and Neoproterozoic on the formed crust, while the metasedimentary rocks formed due to the Mesoproterozoic, more rarely Paleoproterozoic and Archean continental provenances. It has been established that the rocks of the Butugol metamorphic Complex have a different history of development from other blocks of the earth’s crust as part of the composite Tuva-Mongolian microcontinent.
GEOMAGNETIC EFFECT OF THE EARTHQUAKES <i>M</i>w = 7.5–7.8 IN TURKEY ON FEBRUARY 6, 2023
Authors: Soloviev A. A. 
Published: April 2024

We study the response in geomagnetic field variations caused by a series of earthquakes with magnitudes Mw = 7.5–7.8 in Turkey on 6 February 2023. Initial data represent high-precision observations of the geomagnetic field with a 1-s sampling rate recorded at magnetic observatories of Russia and neighboring countries from middle to high latitudes. The paper analyzes the morphology of the geomagnetic signal, its amplitude-frequency characteristics, pulses in the rate of change and delays of the geomagnetic field response to earthquakes with magnitudes Mw = 7–8 depending on the distance to the source. The results suggest that the geomagnetic effect is best detected in the rate of change recordings, reaching anomalous amplitudes of 10 nT/s. The signal delay is from 221 to 592 s depending on the magnetic field component and the distance to the epicenter, which for the selected observatories falls in the range from 765 to 2650 km.
ADAPTIVE DOMAIN-SPECIFIC NAMED ENTITY RECOGNITION METHOD WITH LIMITED DATA
Authors: DYCHKA Ivan , POTAPOVA Kateryna , VOVK Liliya , MELIUKH Vasyl , VEDENIEIEVA Olga 
Published: April 2024

The ever-evolving volume of digital information requires the development of innovative search strategies aimed at obtaining the necessary data efficiently and economically feasible. The urgency of the problem is emphasized by the growing complexity of information landscapes and the need for fast data extraction methodologies. In the field of natural language processing, named entity recognition (NER) is an essential task for extracting useful information from unstructured text input for further classification into predefined categories. Nevertheless, conventional methods frequently encounter difficulties when confronted with a limited amount of labeled data, posing challenges in real-world scenarios where obtaining substantial annotated datasets is problematic or costly. In order to address the problem of domain-specific NER with limited data, this work investigates NER techniques that can overcome these constraints by continuously learning from newly collected information on pre-trained models. Several techniques are also used for making the greatest use of the limited labeled data, such as using active learning, exploiting unlabeled data, and integrating domain knowledge. Using domain-specific datasets with different levels of annotation scarcity, the fine-tuning process of pre-trained models, such as transformer-based models (TRF) and Toc2Vec (token-to-vector) models is investigated. The results show that, in general, expanding the volume of training data enhances most models' performance for NER, particularly for models with sufficient learning ability. Depending on the model architecture and the complexity of the entity label being learned, the effect of more data on the model's performance can change. After increasing the training data by 20%, the LT2V model shows the most balanced growth in accuracy overall by 11% recognizing 73% of entities and processing speed. Meanwhile, with consistent processing speed and the greatest F1-score, the Transformer-based model (TRF) shows promise for effective learning with less data, achieving 74% successful prediction and a 7% increase in performance after expanding the training data to 81%. Our results pave the way for the creation of more resilient and efficient NER systems suited to specialized domains and further the field of domain-specific NER with sparse data. We also shed light on the relative merits of various NER models and training strategies, and offer perspectives for future research.
Dinamika Keterlibatan Masyarakat dalam Program Pemerintah Lokal: Studi Kasus Program Pengelolaan Perikanan Budidaya di Kabupaten Pangkep
Authors: Samsir Andi Novita , Susanti Gita 
Published: April 2024

Partisipasi masyarakat merupakan salah satu subjek utama dalam ranah administrasi publik yang mendukung baik buruknya tata kelola pemerintahan. Rendahnya partisipasi masyarakat dalam mendukung ketercapaian program, menjadi salah satu penyebab tidak idealnya keberlangsungan program pemerintahan. Tujuan dari penelitian ini adalah untuk menganalisis seberapa jauh Tingkat Partisipasi Masyarakat Dalam Program Pengelolaan Perikanan Budidaya pada Dinas Kelautan dan Perikanan Kabupaten Pangkep. Penelitian ini menggunakan metode penelitian kualitatif dengan penelitian deskriptif. Adapun data dianalisis menggunakan model analisis oleh (Miles & Huberman, 1994) dengan teknik reduksi data, penyajian data, dan penarikan kesimpulan. Hasil penelitian menunjukkan bahwa tingkat partisipasi masyarakat dalam Program Pengelolaan Perikanan Budidaya dengan menggunakan pendekatan ladder of citizen empowerment (Burns, Hambleton dan Hogget, 1994) yakni pelaksanaan program berada pada tingkat citizen non-participation dan tingkat citizen participation. (1) Citizen non-partcipation terlihat dari adanya distorsi informasi berupa civic hype dan poor information. Civic hype dimaksud sebagai upaya dinas untuk menarik minat warga dalam berpartisipasi sedangkan poor information terjadi dikarenakan adanya keterbatasan dinas dalam menjangkau pembudidaya pada daerah kepulauan. (2) Citizen participation, menyentuh aspek high quality information, genuine consultation, effective advisory board dan partnership. Keempat anak tangga tersebut menyiratkan bahwa tersedianya akses informasi dan wadah masyarakat dalam menyampaikan aspirasinya. baik itu melalui kunjungan penyuluh, media sosial, musrenbang, maupun melalui lembaga kemasyarakatan.
Estudiantes de escuela secundaria pensando los números racionales
Authors: Palacios Amaya Maximiliano , Bianchi Verónica , Montoro Virginia 
Published: April 2024

En el marco de un estudio sobre las concepciones de estudiantes de secundaria acerca de los números racionales, se diseñó un cuestionario con cuatro actividades orientadas a indagar dicha comprensión. Se aplicó este cuestionario a 132 estudiantes de distintos años de escolaridad, de una escuela secundaria pública de Bariloche (Argentina). Se categorizaron las respuestas a cada una de las actividades con controles inter-juez. Posteriormente se realizó un Análisis Factorial de Correspondencias Múltiple y Clasificación Jerárquica de las respuestas de los estudiantes y se buscaron asociaciones de las clases resultantes con el nivel de estudio de los mismos. En cuanto a las concepciones de los estudiantes, encontramos un gradiente que se expresa desde una ajenidad respecto al tema, le sigue una fase intermedia asociada principalmente con relacionar los números racionales con objetos previamente vistos como son los números enteros o números decimales y finalmente encontramos una comprensión de los racionales mas cercana al respectivo concepto matemático y un buen manejo general de las propiedades de orden y densidad, presente en los estudiantes más avanzados.
Development of a new loop-mediated isothermal amplification test for the sensitive, rapid, and economic detection of different genotypes of Classical swine fever virus
Authors: Bohórquez Jose Alejandro , Muñoz-Aguilera Adriana , Lanka Saraswathi , Coronado Liani , Rosell Rosa , Alberch Mònica , Maddox Carol W. , Ganges Llilianne 
Published: April 2024

BackgroundClassical swine fever virus (CSFV) remains one of the most important pathogens in animal health. Pathogen detection relies on viral RNA extraction followed by RT-qPCR. Novel technologies are required to improve diagnosis at the point of care.MethodsA loop-mediated isothermal amplification (LAMP) PCR technique was developed, with primers designed considering all reported CSFV genotypes. The reaction was tested using both fluorometric and colorimetric detection, in comparison to the gold standard technique. Viral strains from three circulating CSFV genotypes were tested, as well as samples from infected animals. Other pathogens were also tested, to determine the LAMP specificity. Besides laboratory RNA extraction methods, a heating method for RNA release, readily available for adaptation to field conditions was evaluated.ResultsThree primer sets were generated, with one of them showing better performance. This primer set proved capable of maintaining optimal performance at a wide range of amplification temperatures (60°C - 68°C). It was also able to detect CSFV RNA from the three genotypes tested. The assay was highly efficient in detection of samples from animals infected with field strains from two different genotypes, with multiple matrices being detected using both colorimetric and fluorometric methods. The LAMP assay was negative for all the unrelated pathogens tested, including Pestiviruses. The only doubtful result in both fluorometric and colorimetric LAMP was against the novel Pestivirus italiaense, ovine Italy Pestivirus (OVPV), which has proven to have cross-reaction with multiple CSFV diagnostic techniques. However, it is only possible to detect the OVPV in a doubtful result if the viral load is higher than 10000 viral particles.ConclusionThe results from the present study show that LAMP could be an important addition to the currently used molecular diagnostic techniques for CSFV. This technique could be used in remote locations, given that it can be adapted for successful use with minimal equipment and minimally invasive samples. The joined use of novel and traditional diagnostic techniques could prove to be a useful alternative to support the CSF control.
Comprehensive assessment of HF-rTMS treatment mechanism for post-stroke dysphagia in rats by integration of fecal metabolomics and 16S rRNA sequencing
Authors: Zhao Fei , Chen Jiemei , Shan Yilong , Hong Jiena , Ye Qiuping , Dai Yong , Hu Jiahui , Zhang Jiantao , Li Chao , Wen Hongmei 
Published: April 2024

BackgroundThe mechanism by which high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) improves swallowing function by regulating intestinal flora remains unexplored. We aimed to evaluate this using fecal metabolomics and 16S rRNA sequencing.MethodsA Post-stroke dysphagia (PSD) rat model was established by middle cerebral artery occlusion. The magnetic stimulation group received HF-rTMS from the 7th day post-operation up to 14th day post-surgery. Swallowing function was assessed using a videofluoroscopic swallowing study (VFSS). Hematoxylin-eosin (H&amp;E) staining was used to assess histopathological changes in the intestinal tissue. Intestinal flora levels were evaluated by sequencing the 16S rRNA V3-V4 region. Metabolite changes within the intestinal flora were evaluated by fecal metabolomics using liquid chromatography-tandem mass spectrometry.ResultsVFSS showed that the bolus area and pharyngeal bolus speed were significantly decreased in PSD rats, while the bolus area increased and pharyngeal transit time decreased after HF-rTMS administration (p &lt; 0.05). In the PSD groups, H&amp;E staining revealed damaged surface epithelial cells and disrupted cryptal glands, whereas HF-rTMS reinforced the integrity of the intestinal epithelial cells. 16S rRNA sequencing indicated that PSD can disturb the intestinal flora and its associated metabolites, whereas HF-rTMS can significantly regulate the composition of the intestinal microflora. Firmicutes and Lactobacillus abundances were lower in the PSD group than in the baseline group at the phylum and genus levels, respectively; however, both increased after HF-rTMS administration. Levels of ceramides (Cer), free fatty acids (FA), phosphatidylethanolamine (PE), triacylglycerol (TAG), and sulfoquinovosyl diacylglycerol were increased in the PSD group. The Cer, FA, and DG levels decreased after HF-rTMS treatment, whereas the TAG levels increased. Peptococcaceae was negatively correlated with Cer, Streptococcus was negatively correlated with DG, and Acutalibacter was positively correlated with FA and Cer. However, these changes were effectively restored by HF-rTMS, resulting in recovery from dysphagia.ConclusionThese findings suggest a synergistic role for the gut microbiota and fecal metabolites in the development of PSD and the therapeutic mechanisms underlying HF-rTMS.
Diagnostic and prognostic value of angiography-derived index of microvascular resistance: a systematic review and meta-analysis
Authors: Wang Dayang , Li Xiaoming , Feng Wei , Zhou Hufang , Peng Wenhua , Wang Xian 
Published: April 2024

BackgroundThe angiography-derived index of microvascular resistance (A-IMR) is a novel tool for diagnosing coronary microvascular dysfunction (CMD) addressing limitation of unavailability. However, the clinical value of A-IMR remains controversial.MethodsA systematic review and meta-analysis was conducted. PubMed, EMBASE, Cochrane Library and Web of Science were searched for relevant studies. Studies that reported estimates of A-IMR's diagnostic accuracy (with thermodilution-based IMR as the reference test) and/or predictions of adverse cardiovascular events were selected. Pooled sensitivity, specificity, area under the summary receiver operating characteristic curve (sROC) were calculated to measure diagnostic performance; pooled hazard/risk ratio (HR/RR) and 95% confidence interval (95% CI) of major adverse cardiovascular events (MACE) or other independent adverse events were calculated to measure prognostic effect. This study was registered with PROSPERO (CRD42023451884).ResultsA total of 12 diagnostic studies pooling 1,642 vessels and 12 prognostic studies pooling 2,790 individuals were included. A-IMR yielded an area under sROC of 0.93 (95% CI: 0.91, 0.95), a pooled sensitivity of 0.85 (95% CI: 0.79, 0.89) and a pooled specificity of 0.89 (95% CI: 0.83, 0.93) for the diagnosis of CMD. CMD diagnosed using A-IMR was associated with higher risks of MACE (HR, 2.73, 95% CI: 2.16, 3.45), CV death (RR, 2.39, 95% CI: 1.49, 3.82) and heart failure hospitalization (HR, 2.30, 95% CI: 1.53, 3.45).ConclusionA-IMR demonstrated high diagnostic accuracy for CMD and showed a strong prognostic capability in predicting the risk of adverse CV outcomes.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023451884, PROSPERO (CRD42023451884).
Research hot spots and trends in endocrine-related adverse events caused by immune checkpoint inhibitors: a bibliometric analysis and visualization research
Authors: Zhao Jun , Liu Guangwei , Yang Xue , Zhang Chuanzhou , Han Bing , Jiang Man 
Published: April 2024

BackgroundIn recent years, with the widespread use of immune checkpoint inhibitors (ICIs) in cancer treatment, the toxicity associated with immunotherapy of ICIs has attracted more attention from scholars. Endocrine toxicity is the most likely immune-related adverse events (irAEs) and is often irreversible, posing a significant clinical treatment challenge.MethodsIn this study, bibliometric methods were used to analyze relevant literature in screening endocrine-related adverse events caused by ICIs in the Web of Science core collection database (WoSCC) and to summarize the status, research hot spots, and future trends in this field.Results321 countries, 297 institutions, 365 authors, and 305 journals had published 671 English documents on endocrine adverse reactions of ICIs as of 1 December, 2022. The United States, Japan, and China were the top three countries with the most publications. The University of Texas MD Anderson Cancer Center, Harvard Medical School, and Memorial Sloan Kettering Cancer Center were the top three research institutions in terms of publication output. F Stephen Hodi, from the Dana-Farber Cancer Institute in the United States, contributed the largest number of publications. Frontiers in Oncology, which was the most widely distributed publication in the field. The main keywords or clusters identified that current research hotspots include the management of endocrine-related adverse events, hypophysitis, thyroid dysfunction, type I diabetes mellitus, and the impact of endocrine adverse events on survival of patients in this field.ConclusionThe basic knowledge structure of the field of endocrine-related adverse events of ICIs, including publication trends, authors, institutions, countries, keywords, journals and publications, and cited documents, was visually analyzed in this bibliometric analysis. The research results comprehensively demonstrated the hot spots and future trends in the research field, as well as its broad prospects, thus providing a reference for the researchers.
Identifying serum metabolite biomarkers for autoimmune diseases: a two-sample mendelian randomization and meta-analysis
Authors: Wang Wenwen , Huang Manli , Ge Wei , Feng Junling , Zhang Xihua , Li Chen , Wang Ling 
Published: April 2024

BackgroundExtensive evidence suggests a link between alterations in serum metabolite composition and various autoimmune diseases (ADs). Nevertheless, the causal relationship underlying these correlations and their potential utility as dependable biomarkers for early AD detection remain uncertain.ObjectiveThe objective of this study was to employ a two-sample Mendelian randomization (MR) approach to ascertain the causal relationship between serum metabolites and ADs. Additionally, a meta-analysis incorporating data from diverse samples was conducted to enhance the validation of this causal effect.Materials and methodsA two-sample MR analysis was performed to investigate the association between 486 human serum metabolites and six prevalent autoimmune diseases: systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), inflammatory bowel disease (IBD), dermatomyositis (DM), type 1 diabetes (T1D), and celiac disease (CeD). The inverse variance weighted (IVW) model was employed as the primary analytical technique for the two-sample MR analysis, aiming to identify blood metabolites linked with autoimmune diseases. Independent outcome samples were utilized for further validation of significant blood metabolites. Additional sensitivity analyses, including heterogeneity test, horizontal pleiotropy test, and retention rate analysis, were conducted. The results from these analyses were subsequently meta-integrated. Finally, metabolic pathway analysis was performed using the KEGG and Small Molecule Pathway Databases (SMPD).ResultsFollowing the discovery and replication phases, eight metabolites were identified as causally associated with various autoimmune diseases, encompassing five lipid metabolism types: 1-oleoylglycerophosphoethanolamine, 1-arachidonoylglycerophosphoethanolamine, 1-myristoylglycerophosphocholine, arachidonate (20:4 n6), and glycerol. The meta-analysis indicated that three out of these eight metabolites exhibited a protective effect, while the remaining five were designated as pathogenic factors. The robustness of these associations was further confirmed through sensitivity analysis. Moreover, an investigation into metabolic pathways revealed a significant correlation between galactose metabolism and autoimmune diseases.ConclusionThis study revealed a causal relationship between lipid metabolites and ADs, providing novel insights into the mechanism of AD development mediated by serum metabolites and possible biomarkers for early diagnosis.
The role of probiotic therapy on clinical parameters and human immune response in peri-implant diseases: a systematic review and meta-analysis of randomized clinical studies
Authors: López-Valverde Nansi , López-Valverde Antonio , Blanco Rueda José Antonio 
Published: April 2024

BackgroundPeri-implant diseases (peri-implant mucositis and peri-implantitis) are pathologies of an infectious-inflammatory nature of the mucosa around dental implants. Probiotics are microorganisms that regulate host immunomodulation and have shown positive results in the treatment of peri-implant diseases. The objective of the systematic review and meta-analysis was to evaluate the efficacy of probiotics in the treatment of peri-implant oral diseases.MethodsAccording to the PRISMA guidelines, the research question was established: Are probiotics able to favorably modify clinical and immunological biomarkers determinants of peri-implant pathologies? and an electronic search of the databases MEDLINE/PubMed, Embase, Cochrane Central, Web of Science, (until December 2023) was performed. Inclusion criteria were established for intervention studies (RCTs), according to the PICOs strategy in subjects with peri-implant pathology (participants), treated with probiotics (intervention) compared to patients with conventional treatment or placebo (control) and evaluating the response to treatment (outcomes). Results- 1723 studies were obtained and 10 were selected. Risk of bias was assessed using the Cochrane Risk of Bias Tool and methodological quality using the Joanna Briggs Institute for RCTs. Two meta-analyses were performed, one to evaluate probiotics in mucositis and one for peri-implantitis. All subgroups were homogeneous (I2 = 0%), except in the analysis of IL-6 in mucositis (I2 = 65%). The overall effect was favorable to the experimental group in both pathologies. The analysis of the studies grouped in peri-implantitis showed a tendency to significance (p=0.09).ConclusionThe use of probiotics, as basic or complementary treatment of peri-implant diseases, showed a statistically significant trend, but well-designed studies are warranted to validate the efficacy of these products in peri-implant pathologies.