bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predicted $$\varXi _b(6087)^0$$ and further predictions
Authors: Tan Wei-Han , Yang Hui-Min , Chen Hua-Xing 
Published: April 2024

AbstractThe methods of QCD sum rules and light-cone sum rules within the framework of heavy quark effective theory have been widely applied to study the singly heavy baryons, and especially, we have applied these methods to predict not only the mass and width of the $$\varXi _b(6087)^0$$

Ξ
b

(
6087
)

0

recently discovered by LHCb, but also its observation channel and its mass difference from the $$\varXi _b(6100)^-$$

Ξ
b

(
6100
)

-

. We apply the same approach to perform a complete study on the P-wave bottom baryons of the SU(3) flavor $${\bar{\textbf{3}}}_F$$

3

¯

F

and investigate their fine structure. Besides the $$\varLambda _b(5912)^0$$

Λ
b

(
5912
)

0

, $$\varLambda _b(5920)^0$$

Λ
b

(
5920
)

0

, $$\varXi _b(6087)^0$$

Ξ
b

(
6087
)

0

, and $$\varXi _b(6100)^-$$

Ξ
b

(
6100
)

-

, our results suggest the existence of the other two $$\varLambda _b$$

Λ
b

and two $$\varXi _b$$

Ξ
b

baryons, whose widths are limited. They are the $$\varLambda _b(J^P = 3/2^-)$$

Λ
b

(

J
P

=
3
/

2
-

)

with the mass and width about $$(5.93^{+0.13}_{-0.13}~\textrm{GeV},\,0.0^{+12.0}_{-~0.0}~\textrm{MeV})$$

(
5
.

93

-
0.13

+
0.13

GeV
,

0
.

0

-

0.0

+
12.0

MeV
)

, the $$\varLambda _b(5/2^-)$$

Λ
b

(
5
/

2
-

)

with $$(5.94^{+0.13}_{-0.13}~\textrm{GeV},\,\approx 0~\textrm{MeV})$$

(
5
.

94

-
0.13

+
0.13

GeV
,

≈
0

MeV
)

, the $$\varXi _b(3/2^-)$$

Ξ
b

(
3
/

2
-

)

with $$(6.10^{+0.15}_{-0.10}~\textrm{GeV},\, 1.4{^{+11.6}_{-~1.4}}~\textrm{MeV})$$

(
6
.

10

-
0.10

+
0.15

GeV
,

1.4

-

1.4

+
11.6

MeV
)

, and the $$\varXi _b(5/2^-)$$

Ξ
b

(
5
/

2
-

)

with $$(6.11^{+0.15}_{-0.10}~\textrm{GeV},\,1.0{^{+7.4}_{-1.0}}~\textrm{MeV})$$

(
6
.

11

-
0.10

+
0.15

GeV
,

1.0

-
1.0

+
7.4

MeV
)

. Their mass splittings are calculated to be $$M_{\varLambda _b(5/2^-)} - M_{\varLambda _b(3/2^-)} = 17\pm 7~\textrm{MeV}$$

M

Λ
b

(
5
/

2
-

)

-

M

Λ
b

(
3
/

2
-

)

=
17
±
7

MeV

and $$M_{\varXi _b(5/2^-)} - M_{\varXi _b(3/2^-)} = 14\pm 7~\textrm{MeV}$$

M

Ξ
b

(
5
/

2
-

)

-

M

Ξ
b

(
3
/

2
-

)

=
14
±
7

MeV

. All these baryons are explained as the P-wave bottom baryons of the $$\rho $$
ρ
-mode, where the orbital excitation is between the two light quarks. However, the existence of this mode is still controversial, so their experimental searches can verify both our approach and the existence of the $$\rho $$
ρ
-mode, which can significantly improve our understanding on the internal structure of hadrons.
Constraining the attractive fifth force in the general free scalar–tensor gravity with solar system experiments
Authors: Zhang Xing , Wang Bo , Niu Rui 
Published: April 2024

AbstractIn this paper, we focus on the general free scalar–tensor gravity with three free coupling functions, which in the near-field region looks like general relativity (GR) plus a fifth force of Yukawa-type induced by the scalar field. We show that the fifth force is always attractive in the theory. We investigate the effects of the attractive fifth force and calculate in detail the fifth force-induced orbital precession rate$$\delta \omega /\omega $$δω/ωand the parameterized post-Newtonian parameters$$\gamma $$γand$$\beta $$β, all of which depend on the fifth force parameters and the interaction distance. It turns out that, due to the attractive fifth force,$$\delta \omega /\omega $$δω/ωis always greater than zero,$$\gamma $$γis always less than one,$$\beta $$βis greater than one at large distances, and additionally this class of theories is ruled out as an alternative theory to dark matter. We place stringent constraints on the fifth force parameters by combining the lunar laser ranging (LLR), Cassini, and Mercury precession experiments, and derive the upper bounds on the strength ratio of the fifth force to gravitational force at different scales from the LLR observation. We find that the Mercury constraint is not competitive with the LLR and Cassini constraints and the LLR observation imposes much more stringent bounds on the strength ratio on large scales than on small scales. Our results show that this theory is sufficiently close to GR for a small enough fifth force strength and can reduce to GR with a minimally coupled scalar field in the absence of fifth force.
$$D_s \rightarrow f_0(980)$$ form factors and the $$D_s^+ \rightarrow (f_0(980) \rightarrow )\left[ \pi \pi \right] _{S}^{\textrm{I} = 0} e^+ \nu _e$$ decay from light-cone sum rules
Authors: Cheng Shan , Zhang Shu-Lei 
Published: April 2024

AbstractIn this paper we revisit $$D_s \rightarrow f_0(980)$$

D
s

→

f
0

(
980
)

form factors from the light-cone sum rules based on the $${\bar{q}}q$$

q

¯

q

picture of $$f_0(980)$$

f
0

(
980
)

. The main motivation of this study is the decay width of $$D_s^+ \rightarrow \left[ \pi \pi \right] _{S}^{\textrm{I} = 0} e^+ \nu _e$$

D
s
+

→

π
π

S

I
=
0

e
+

ν
e

measured recently by BESIII collaboration and the $$D_s \rightarrow f_0(980)$$

D
s

→

f
0

(
980
)

form factor extracted under the resonant model, here the subscript S and superscript $$\textrm{I}=0$$

I
=
0

indicate the S-wave isoscalar dipion system. Our result of the differential width of $$D_s^+ \rightarrow f_0(980) (\rightarrow \left[ \pi \pi \right] _{S}^{\textrm{I} = 0}) e^+ \nu _e$$

D
s
+

→

f
0

(
980
)

(
→

π
π

S

I
=
0

)

e
+

ν
e

decay obtained under the narrow width approximation is lower than the data, the result obtained under the resonant Flatté model is consistent with the data, indicating a sizable mixing $$\sim 20^{\circ }$$

∼

20
∘

between $${\bar{s}}s$$

s

¯

s

and $${\bar{u}}u+{\bar{d}}d$$

u

¯

u
+

d

¯

d

of $$f_0$$

f
0

. In order to get a model independent prediction, we suggest to calculate $$D_s \rightarrow \left[ \pi \pi \right] ^{\textrm{I} = 0}$$

D
s

→

π
π

I
=
0

form factors with the isoscalar dipion light-cone distribution amplitudes. Our calculation of $$D_s \rightarrow \left[ \pi \pi \right] ^{\textrm{I} = 0}$$

D
s

→

π
π

I
=
0

form factors is carried out at leading twist level due to the finite knowledge of dipion system, the differential width shows a moderate evolution in contrast to that obtained from the narrow width approximation and the Flatté model. Since the $$D_s \rightarrow f_0(980)$$

D
s

→

f
0

(
980
)

form factors is dominated by the twist three contribution, further measurements on four-body semileptonic charm decays would help us to study the dimeson light-cone distribution amplitudes, especially for the subleading twist one.
Edge incident 2-edge coloring of graphs
Authors: Joseph Anu , Dominic Charles 
Published: April 2024

The edge incident 2-edge coloring of a graph [Formula: see text] is an edge coloring of the graph [Formula: see text] such that not more than two colors are assigned to the edges incident to an edge [Formula: see text] in [Formula: see text]. In other words, for every edge [Formula: see text] in [Formula: see text], the edge [Formula: see text] and all the edges that are incident to the edge [Formula: see text] is in at most two different color classes. The edge incident 2-edge coloring number [Formula: see text] is the maximum number of colors in any edge incident 2-edge coloring of [Formula: see text]. The main objective of this paper is to study the edge incident 2-edge coloring concept and apply the same to some graph classes. Besides finding the exact values of these parameters, we also obtain some bounds.
CB307: A Dual Targeting Costimulatory Humabody VH Therapeutic for Treating PSMA-Positive Tumors
Authors: Archer Sophie , Brailey Phillip M. , Song Minjung , Bartlett Phillip D. , Figueiredo Ines , Gurel Bora , Guo Christina , Brucklacher-Waldert Verena , Thompson H. Lorraine , Akinwale Jude , Boyle Samantha E. , Rossant Christine , Birkett Neil R. , Pizzey Julia , Maginn Mark , Legg James , Williams Richard , Johnston Colette M. , Bland-Ward Philip , de Bono Johann S. , Pierce Andrew J. 
Published: April 2024

Abstract

Purpose:
CD137 is a T- and NK-cell costimulatory receptor involved in consolidating immunologic responses. The potent CD137 agonist urelumab has shown clinical promise as a cancer immunotherapeutic but development has been hampered by on-target off-tumor toxicities. A CD137 agonist targeted to the prostate-specific membrane antigen (PSMA), frequently and highly expressed on castration-resistant metastatic prostate cancer (mCRPC) tumor cells, could bring effective immunotherapy to this immunologically challenging to address disease.

Experimental Design:
We designed and manufactured CB307, a novel half-life extended bispecific costimulatory Humabody VH therapeutic to elicit CD137 agonism exclusively in a PSMA-high tumor microenvironment (TME). The functional activity of CB307 was assessed in cell-based assays and in syngeneic mouse antitumor pharmacology studies. Nonclinical toxicology and toxicokinetic properties of CB307 were assessed in a good laboratory practice (GLP) compliant study in cynomolgus macaques.

Results:
CB307 provides effective CD137 agonism in a PSMA-dependent manner, with antitumor activity both in vitro and in vivo, and additional activity when combined with checkpoint inhibitors. A validated novel PSMA/CD137 IHC assay demonstrated a higher prevalence of CD137-positive cells in the PSMA-expressing human mCRPC TME with respect to primary lesions. CB307 did not show substantial toxicity in nonhuman primates and exhibited a plasma half-life supporting weekly clinical administration.

Conclusions:
CB307 is a first-in-class immunotherapeutic that triggers potent PSMA-dependent T-cell activation, thereby alleviating toxicologic concerns against unrestricted CD137 agonism.
Discovery of a Long Half-Life AURKA Inhibitor to Treat MYC-Amplified Solid Tumors as a Monotherapy and in Combination with Everolimus
Authors: Chang Chun-Ping , Yeh Teng-Kuang , Chen Chiung-Tong , Wang Wan-Ping , Chen Yen-Ting , Tsai Chia-Hua , Chen Yan-Fu , Ke Yi-Yu , Wang Jing-Ya , Chen Ching-Ping , Hsieh Tsung-Chih , Wu Mine-Hsine , Huang Chen-Lung , Chen Ya-Ping , Zhuang Hong , Chi Ya-Hui 
Published: April 2024

Abstract
Aurora kinase inhibitors, such as alisertib, can destabilize MYC-family oncoproteins and have demonstrated compelling antitumor efficacy. In this study, we report 6K465, a novel pyrimidine-based Aurora A inhibitor, that reduces levels of c-MYC and N-MYC oncoproteins more potently than alisertib. In an analysis of the antiproliferative effect of 6K465, the sensitivities of small cell lung cancer (SCLC) and breast cancer cell lines to 6K465 were strongly associated with the protein levels of c-MYC and/or N-MYC. We also report DBPR728, an acyl-based prodrug of 6K465 bearing fewer hydrogen-bond donors, that exhibited 10-fold improved oral bioavailability. DBPR728 induced durable tumor regression of c-MYC- and/or N-MYC-overexpressing xenografts including SCLC, triple-negative breast cancer, hepatocellular carcinoma, and medulloblastoma using a 5-on-2-off or once-a-week dosing regimen on a 21-day cycle. A single oral dose of DBPR728 at 300 mg/kg induced c-MYC reduction and cell apoptosis in the tumor xenografts for more than 7 days. The inhibitory effect of DBPR728 at a reduced dosing frequency was attributed to its uniquely high tumor/plasma ratio (3.6-fold within 7 days) and the long tumor half-life of active moiety 6K465. Furthermore, DBPR728 was found to synergize with the mTOR inhibitor everolimus to suppress c-MYC- or N-MYC-driven SCLC. Collectively, these results suggest DBPR728 has the potential to treat cancers overexpressing c-MYC and/or N-MYC.
Ektaphelenchoides factum n. sp. in Pinus taeda from the USA and E. pini in Pinus koraiensis from China
Authors: Gu Jianfeng , Munawar Maria , Ma Xinxin , Fang Yiwu 
Published: April 2024

Summary
The genus Ektaphelenchoides is a diverse group of nematodes; they are either inhabitants of trees or present in the rhizosphere of economical plants. Members of the genus have ecological relevance in terms of being associated with insects and predators of other nematodes. In the present study, a new Ektaphelenchoides species, E. factum n. sp., is described and illustrated. The new species was isolated from a log sample of Pinus taeda imported from the USA. It is characterised by the lateral field with three incisures, stylet distinctly tripartite. Females having a vulval flap, the anus and rectum indistinct, and the tail (posterior part of body) filiform. Males having arcuate and 21.5 (19.4-22.9) μm long spicules, the lamina of the spicule is smoothly curved to distal end, condylus well developed with a broadly rounded tip, rostrum triangular with finely rounded tip and cucullus absent, tail arcuate and conical with terminus bearing a sharply pointed mucron. The new species is different from other Ektaphelenchoides species in having a vulval flap. Molecular characterisation and phylogenetic studies also supported its unique status. In addition, a Chinese native population of E. pini, detected in Pinus koraiensis branches from Liaoning province, P.R. China, is described.
Predicting inhibitor development using a random peptide phage-display library approach in the SIPPET cohort
Authors: Hassan Shermarke , Baselli Guido , Mollica Luca , Rossi Riccardo L. , Chand Himani , El-Beshlawy Amal , Elalfy Mohsen , Ramanan Vijay , Eshghi Peyman , Karimi Mehran , Palla Roberta , Rosendaal Frits R. , Peyvandi Flora 
Published: April 2024

Abstract
Inhibitor development is the most severe complication of hemophilia A (HA) care and is associated with increased morbidity and mortality. This study aimed to use a novel immunoglobulin G epitope mapping method to explore the factor VIII (FVIII)–specific epitope profile in the SIPPET cohort population and to develop an epitope mapping–based inhibitor prediction model. The population consisted of 122 previously untreated patients with severe HA who were followed up for 50 days of exposure to FVIII or 3 years, whichever occurred first. Sampling was performed before FVIII treatment and at the end of the follow-up. The outcome was inhibitor development. The FVIII epitope repertoire was assessed by means of a novel random peptide phage-display assay. A least absolute shrinkage and selection operator (LASSO) regression model and a random forest model were fitted on posttreatment sample data and validated in pretreatment sample data. The predictive performance of these models was assessed by the C-statistic and a calibration plot. We identified 27 775 peptides putatively directed against FVIII, which were used as input for the statistical models. The C-statistic of the LASSO and random forest models were good at 0.78 (95% confidence interval [CI], 0.69-0.86) and 0.80 (95% CI, 0.72-0.89). Model calibration of both models was moderately good. Two statistical models, developed on data from a novel random peptide phage display assay, were used to predict inhibitor development before exposure to exogenous FVIII. These models can be used to set up diagnostic tests that predict the risk of inhibitor development before starting treatment with FVIII.
Plasma kallikrein supports FXII-independent thrombin generation in mouse whole blood
Authors: Wan Jun , Dhrolia Sophia , Kasthuri Rohan R. , Prokopenko Yuriy , Ilich Anton , Saha Prakash , Roest Mark , Wolberg Alisa S. , Key Nigel S. , Pawlinski Rafal , Bendapudi Pavan K. , Mackman Nigel , Grover Steven P. 
Published: April 2024

Abstract
Plasma kallikrein (PKa) is an important activator of factor XII (FXII) of the contact pathway of coagulation. Several studies have shown that PKa also possesses procoagulant activity independent of FXII, likely through its ability to directly activate FIX. We evaluated the procoagulant activity of PKa using a mouse whole blood (WB) thrombin-generation (TG) assay. TG was measured in WB from PKa-deficient mice using contact pathway or extrinsic pathway triggers. PKa-deficient WB had significantly reduced contact pathway–initiated TG compared with that of wild-type controls and was comparable with that observed in FXII-deficient WB. PKa-deficient WB supported equivalent extrinsic pathway–initiated TG compared with wild-type controls. Consistent with the presence of FXII-independent functions of PKa, targeted blockade of PKa with either small molecule or antibody-based inhibitors significantly reduced contact pathway–initiated TG in FXII-deficient WB. Inhibition of activated FXII (FXIIa) using an antibody-based inhibitor significantly reduced TG in PKa-deficient WB, consistent with a PKa-independent function of FXIIa. Experiments using mice expressing low levels of tissue factor demonstrated that persistent TG present in PKa- and FXIIa-inhibited WB was driven primarily by endogenous tissue factor. Our work demonstrates that PKa contributes significantly to contact pathway–initiated TG in the complex milieu of mouse WB, and a component of this contribution occurs in an FXII-independent manner.
Imaging in pulmonary infections of immunocompetent adult patients
Authors: Pochepnia Svitlana , Grabczak Elzbieta Magdalena , Johnson Emma , Eyuboglu Fusun Oner , Akkerman Onno , Prosch Helmut 
Published: April 2024

Pneumonia is a clinical syndrome characterised by fever, cough and alveolar infiltration of purulent fluid, caused by infection with a microbial pathogen. It can be caused by infections with bacteria, viruses or fungi, but a causative organism is identified in less than half of cases. The most common type of pneumonia is community-acquired pneumonia, which is caused by infections acquired outside the hospital.Current guidelines for pneumonia diagnosis require imaging to confirm the clinical suspicion of pneumonia. Thus, imaging plays an important role in both the diagnosis and management of pneumonia, with each modality having specific advantages and limitations. Chest radiographs are commonly used but have limitations in terms of sensitivity and specificity. Lung ultrasound shows high sensitivity and specificity. Computed tomography scans offer higher diagnostic accuracy but involve higher radiation doses. Radiological patterns, including lobar, lobular and interstitial pneumonia, provide valuable insights into causative pathogens and treatment decisions. Understanding these radiological patterns is crucial for accurate diagnosis. In this review, we will summarise the most important aspects pertaining to the role of imaging in pneumonia and will highlight the imaging characteristics of the most common causative organisms.
Assessment of the FRET-based Teen sensor to monitor ERK activation changes preceding morphological defects in a RASopathy zebrafish model and phenotypic rescue by MEK inhibitor
Authors: Fasano Giulia , Petrini Stefania , Bonavolontà Valeria , Paradisi Graziamaria , Pedalino Catia , Tartaglia Marco , Lauri Antonella 
Published: April 2024

Abstract
Background
RASopathies are genetic syndromes affecting development and having variable cancer predisposition. These disorders are clinically related and are caused by germline mutations affecting key players and regulators of the RAS-MAPK signaling pathway generally leading to an upregulated ERK activity. Gain-of-function (GOF) mutations in PTPN11, encoding SHP2, a cytosolic protein tyrosine phosphatase positively controlling RAS function, underlie approximately 50% of Noonan syndromes (NS), the most common RASopathy. A different class of these activating mutations occurs as somatic events in childhood leukemias.

Method
Here, we evaluated the application of a FRET-based zebrafish ERK reporter, Teen, and used quantitative FRET protocols to monitor non-physiological RASopathy-associated changes in ERK activation. In a multi-level experimental workflow, we tested the suitability of the Teen reporter to detect pan-embryo ERK activity correlates of morphometric alterations driven by the NS-causing Shp2D61G allele.

Results
Spectral unmixing- and acceptor photobleaching (AB)-FRET analyses captured pathological ERK activity preceding the manifestation of quantifiable body axes defects, a morphological pillar used to test the strength of SHP2 GoF mutations. Last, the work shows that by multi-modal FRET analysis, we can quantitatively trace back the modulation of ERK phosphorylation obtained by low-dose MEK inhibitor treatment to early development, before the onset of morphological defects.

Conclusion
This work proves the usefulness of FRET imaging protocols on both live and fixed Teen ERK reporter fish to readily monitor and quantify pharmacologically- and genetically-induced ERK activity modulations in early embryos, representing a useful tool in pre-clinical applications targeting RAS-MAPK signaling.
Chloroplast genomes of Caragana tibetica and Caragana turkestanica: structures and comparative analysis
Authors: Liu LiE , Li HongYan , Li JiaXin , Li XinJuan , Hu Na , Sun Jing , Zhou Wu 
Published: April 2024

Abstract
Background
The genus Caragana encompasses multiple plant species that possess medicinal and ecological value. However, some species of Caragana are quite similar in morphology, so identifying species in this genus based on their morphological characteristics is considerably complex. In our research, illumina paired-end sequencing was employed to investigate the genetic organization and structure of Caragana tibetica and Caragana turkestanica, including the previously published chloroplast genome sequence of 7 Caragana plants.

Results
The lengths of C. tibetica and C. turkestanica chloroplast genomes were 128,433 bp and 129,453 bp, respectively. The absence of inverted repeat sequences in these two species categorizes them under the inverted repeat loss clade (IRLC). They encode 110 and 111 genes (4 /4 rRNA genes, 30 /31tRNA genes, and 76 /76 protein-coding genes), respectively. Comparison of the chloroplast genomes of C. tibetica and C. turkestanica with 7 other Caragana species revealed a high overall sequence similarity. However, some divergence was observed between certain intergenic regions (matK-rbcL, psbD-psbM, atpA-psbI, and etc.). Nucleotide diversity (π) analysis revealed the detection of five highly likely variable regions, namely rps2-atpI, accD-psaI-ycf4, cemA-petA, psbN-psbH and rpoA-rps11. Phylogenetic analysis revealed that C. tibetica’s sister species is Caragana jubata, whereas C. turkestanica’s closest relative is Caragana arborescens.

Conclusions
The present study provides worthwhile information about the chloroplast genomes of C. tibetica and C. turkestanica, which aids in the identification and classification of Caragana species.