bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stereoselective Synthesis of Multifunctionalized 1,2,4‐Triazolidines by a Ruthenium Porphyrin‐Catalyzed Three‐Component Coupling Reaction.
Authors: Wang Ming‐Zhong , Xu Hai‐Wei , Liu Yungen , Wong Man‐Kin , Che Chi‐Ming 
Published: March 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Copper Salt Catalyzed Azide‐[3 + 2] Cycloadditions of Ynamides and Bis‐ynamides.
Authors: Zhang Xuejun , Li Hongyan , You Lingfeng , Tang Yu , Hsung Richard P. 
Published: March 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
RhCl(PPh3)3/DPPF: A Useful and Efficient Catalyst for Cross‐Coupling Reactions of Activated Alkenyl Tosylates with Arylboronic Acids.
Authors: Wu Jie , Zhang Liang , Gao Ke 
Published: March 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Reactions of 3‐(Polyfluoroacyl)chromones with Hydroxylamine. The First Synthesis of 3‐Cyano‐2‐(polyfluoroalkyl)chromones.
Authors: Sosnovskikh Vyacheslav Ya. , Moshkin Vladimir S. , Irgashev Roman A. 
Published: March 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of 7‐Hydroxy‐2‐(2‐hydroxybenzoyl)benzo[c]chromen‐6‐ones by Sequential Application of Domino Reactions of 1,3‐Bis(silyl enol ethers) with Benzopyrylium Triflates.
Authors: Lubbe Mathias , Appel Bettina , Flemming Anke , Fischer Christine , Langer Peter 
Published: March 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Highly Enantioselective Synthesis of 2H‐1‐Benzothiopyrans by a Catalytic Domino Reaction.
Authors: Rios Ramon , Sunden Henrik , Ibrahem Ismail , Zhao Gui‐Ling , Eriksson Lars , Cordova Armando 
Published: March 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Proline‐Catalyzed Imino‐Diels—Alder Reactions: Synthesis of meso‐2,6‐Diaryl‐4‐piperidones.
Authors: Aznar Fernando , Garcia Ana‐Belen , Caball Maria‐Paz 
Published: March 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
The Baylis—Hillman Approach to Quinoline Derivatives.
Authors: Familoni Oluwole B. , Klaas Phindile J. , Lobb Kevin A. , Pakade Vusumzi E. , Kaye Perry T. 
Published: March 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
An Efficient One‐Pot Synthesis of N‐Carboxymethylacridine‐1,8‐dione Derivatives under Microwave Irradiation.
Authors: Tu Shujiang , Wang Qian , Zhang Yan , Xu Jianing , Zhang Jinpeng , Zhu Xiaotong , Shi Feng 
Published: March 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
LnCl3×6H2O Crystal Hydrates as Highly Effective Catalysts in the Synthesis of Alkyl‐Substituted Quinolines and Phenanthrolines.
Authors: Bulgakov R. G. , Kuleshov S. P. , Makhmutov A. R. , Dzhemilev U. M. 
Published: March 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Highly Enantioselective Organocatalytic Biginelli Reaction.
Authors: Chen Xiao‐Hua , Xu Xiao‐Ying , Liu Hua , Cun Lin‐Feng , Gong Liu‐Zhu 
Published: March 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Simple Synthesis of Di(uracilyl)aryl Methanes and 1,ω‐Bis[di(uracilyl)methyl]benzenes.
Authors: Kumar Subodh , Malik Vaishalli , Kaur Navneet , Kaur Kuljit 
Published: March 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Convergent Synthesis of Complex Diketopiperazines Derived from Pipecolic Acid Scaffolds and Parallel Screening Against GPCR Targets.
Authors: Dandapani Sivaraman , Lan Ping , Beeler Aaron B. , Beischel Scott , Abbas Athier , Roth Bryan L. , Porco John A. Jr. , Panek James S. 
Published: March 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Efficient Electrosynthesis of 1,2,4‐Triazino[3,4‐b]‐1,3,4‐thiadiazine Derivatives.
Authors: Fotouhi L. , Mosavi M. , Heravi M. M. , Nematollahi D. 
Published: March 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
NBS as an Efficient Catalyst for the Synthesis of 1,5‐Benzodiazepine Derivatives under Mild Conditions.
Authors: Kuo Chun‐Wei , More Shivaji V. , Yao Ching‐Fa 
Published: March 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Hydrotalcites as Catalysts for the Baeyer—Villiger Oxidation of Cyclic Ketones with Hydrogen Peroxide/Benzonitrile.
Authors: Ruiz Jose Rafael , Jimenez‐Sanchidrian Cesar , Llamas Rafael 
Published: March 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Oxapolycycles from One‐Pot Cross‐Metathesis/Carbonyl Ylide Formation—Intramolecular Cycloaddition of α‐Diazo‐β‐keto Esters.
Authors: Hodgson David M. , Angrish Deepshikha 
Published: March 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Establishment of an Efficient Synthetic Route to 3,4:3′,4′‐Bis(3,6,9‐trioxaundecane‐1,11‐dioxy)benzil.
Authors: Kimura Masaru , Shi Kun , Hashimoto Koji , Hu Zhi Zhi 
Published: March 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Regio‐ and Stereoselective Synthesis of Alkenylphosphines: A Rhodium‐Catalyzed Hydrophosphination of Alkynes Using a Silylphosphine.
Authors: Hayashi Minoru , Matsuura Yutaka , Watanabe Yutaka 
Published: March 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Novel Sesquiterpenoids from the Formosan Soft Coral Paralemnalia thyrsoides.
Authors: Huang Ho‐Cheng , Wen Zhi‐Hong , Chao Chih‐Hua , Ahmed Atallah F. , Chiang Michael Y. , Kuo Yao‐Haur , Hsu Chi‐Hsin , Sheu Jyh‐Horng 
Published: March 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
C9‐Iridoids from Scrophularia buergeriana
Authors: Lin Shuang‐Jun , Tan Chang‐Heng , Jiang Shan‐Hao , Li Yi‐Ming , Zhu Da‐Yuan 
Published: March 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Sigmatropic Rearrangement as Tools for Amino Acid and Peptide Modification: Application of the Allylic Sulfur Ylide Rearrangement to the Preparation of Neoglycoconjugates and Other Conjugates.
Authors: Crich David , Zou Yekui , Brebion Franck 
Published: March 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Efficient Entry to Amino Sugars and Derivatives via Asymmetric Organocatalytic Mannich Reactions.
Authors: Enders Dieter , Gronal Christoph , Vrettou Marianna 
Published: March 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthetic Studies on Perophoramidine and the Communesins: Construction of the Vicinal Quaternary Stereocenters.
Authors: Seo Jae Hong , Artman Gerald D. III , Weinreb Steven M. 
Published: March 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Preparation of Highly Substituted 6‐Arylpurine Ribonucleosides by Ni‐Catalyzed Cyclotrimerization. Scope of the Reaction.
Authors: Turek Pavel , Novak Petr , Pohl Radek , Hocek Michal , Kotora Martin 
Published: March 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of Novel L‐N‐MCd4T as a Potent anti‐HIV Agent.
Authors: Park Ah‐Young , Moon Hyung Ryong , Kim Kyung Ran , Chun Moon Woo , Jeong Lak Shin 
Published: March 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis and anti‐HCMV Activity of Novel Cyclopropyl Phosphonic Acid Nucleosides.
Authors: Kim Aihong , Hong Joon Hee , Oh Chang Hyun 
Published: March 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis and Antibacterial Activities of New 1β‐Methylcarbapenems Having Aminopyrimidinylthioether Moiety.
Authors: Lee K. S. , Lim J. H. , Kang Y. K. , Yoo K. H. , Kim D. C. , Shin K. J. , Kim D. J. 
Published: March 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Moderate Voltage Cathodoluminescence of Y2O2S:Eu, SrGa2S4:Eu, and ZnS:Ag,Al for CNT‐FEDs.
Authors: Na Sang‐Hee , Sung Hye‐Jin , You Yong‐Chan , Ko Ki‐Young , Do Young Rag , Huh Young‐Duk 
Published: March 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Ultrarapid Materials Processing: Synthesis of Tungsten Carbide on Subminute Timescales.
Authors: Vallance Simon R. , Kingman Sam , Gregory Duncan H. 
Published: March 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Selenium‐Based Glasses and Glass Ceramics Transmitting Light from the Visible to the Far‐IR.
Authors: Calvez Laurent , Ma Hong‐Li , Lucas Jacques , Zhang Xiang‐Hua 
Published: March 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Effect of Reduction‐Oxidation Treatment on the Catalytic Activity over Tin Oxide Supported Platinum Catalysts
Authors: Matsui Toshiaki , Okanishi Takeoh , Fujiwara Katsuhiko , Tsutsui Kazuki , Kikuchi Ryuji , Takeguchi Tatsuya , Eguchi Koichi 
Published: March 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
High Magnetic Field Studies of the Shape Memory Alloy AuZn
Authors: McDonald Ross D. , Goddard Paul A. , Lashley Jason , Harrison Neil , Mielke Charles H. , Singleton John , Harima Hisatomo , Suzuki Michi‐To 
Published: March 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Diarylprolinol Ethers: Expanding the Potential of Enamine/Iminium‐Ion Catalysis
Authors: Palomo Claudio , Mielgo Antonia 
Published: March 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
The Synthesis and Antiviral Properties of Acyclic Nucleoside Analogues with a Phosphonomethoxy Fragment in the Side Chain
Authors: Khandazhinskaya A. , Yasko M. , Shirokova E. 
Published: March 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Cheminformatics Analysis and Learning in a Data Pipelining Environment
Authors: Hassan Moises , Brown Robert D. , Varma‐O'Brien Shikha , Rogers David 
Published: March 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Cross‐correlated and conventional dipolar carbon‐13 relaxation in methylene groups in small, symmetric molecules
Authors: Ghalebani Leila , Bernatowicz Piotr , Nikkhou Aski Sahar , Kowalewski Jozef 
Published: March 2007

AbstractA theory for dipolar cross‐correlated relaxation processes in AMX or AX2 spin system, with special reference to 13C‐methylene groups, is reviewed briefly. Simple experiments and protocols for measuring the transfer rates between the carbon‐13 Zeeman order and the three‐spin order, and for their analogues in the transverse plane, are discussed using a concentrated solution of the disaccharide trehalose as a model system. Experimental data sets consisting of conventional carbon‐13 relaxation parameters (T1, T2, and NOE), along with the cross‐correlated relaxation rates, are also presented for some small, rigid, polycyclic molecules. These data are interpreted using spectral density functions appropriate to spherical or symmetric tops reorienting according to small‐step rotational diffusion model. The analysis results in a consistent picture of the auto‐ and cross‐correlated spin relaxation processes. © 2007 Wiley Periodicals, Inc. Concepts Magn Reson Part A 30A: 100–115, 2007.
Gemcitabine plus oxaliplatin (GEMOX) in patients with advanced hepatocellular carcinoma (HCC)
Authors: Louafi Samy , Boige Valérie , Ducreux Michel , Bonyhay Luminita , Mansourbakht Touraj , de Baere Thierry , Asnacios Amani , Hannoun Laurent , Poynard Thierry , Taïeb Julien 
Published: March 2007

AbstractBACKGROUNDNew systemic therapies are needed to improve the prognosis of patients with advanced‐stage hepatocellular carcinoma (HCC). In a Phase II trial involving previously untreated patients with advanced HCC, the more favorable schedule from a previous pilot study was evaluated.METHODSThirty‐four patients with previously untreated advanced‐stage HCC were prospectively enrolled. The GEMOX regimen consisted of gemcitabine 1000 mg/m2 on Day 1 and oxaliplatin 100 mg/m2 on Day 2. The treatment was repeated every 2 weeks until disease progression or limiting toxicity.RESULTSThirty‐two patients were assessable for efficacy and 33 for toxicity. In all, 323 treatment cycles were administered. No toxic deaths occurred. Hematological grade 3‐4 toxicity consisted of thrombocytopenia (27% of patients) and neutropenia (24%), including 2 febrile neutropenia and anemia (9%). Grade 3 oxaliplatin‐induced neurotoxicity was observed in 3 (9%) patients. The overall response rate was 18% (95% confidence interval [CI]: 8‐34) and disease stabilization was observed in 58% of patients (including 5 minor responses), giving a disease control rate of 76%. Median progression‐free and overall survival times were, respectively, 6.3 months (95% CI: 4.3‐10.1 months) and 11.5 months (95% CI: 8.5‐14.3 months). Treatment was significantly more effective in patients with nonalcoholic cirrhosis than in those with alcoholic cirrhosis.CONCLUSIONSThe GEMOX regimen seems to be well tolerated and active in advanced HCC, especially in patients with underlying nonalcoholic liver disease. A Phase II study of the GEMOX regimen plus cetuximab is ongoing. Cancer 2007. © 2007 American Cancer Society.
Soft‐tissue sarcomas in children and adolescents with neurofibromatosis type 1
Authors: Ferrari Andrea , Bisogno Gianni , Macaluso Alessandra , Casanova Michela , D'Angelo Paolo , Pierani Paolo , Zanetti Ilaria , Alaggio Rita , Cecchetto Giovanni , Carli Modesto 
Published: March 2007

AbstractBACKGROUNDPatients affected by neurofibromatosis type 1 (NF1) are at higher risk of developing soft‐tissue sarcomas (STS) than the general population. The clinical findings and outcome in 43 children and adolescents with NF1 treated for STS in the Italian protocols between 1988 and 2004 are reported.METHODSThe study included 37 patients with neurogenic sarcomas (36 malignant peripheral nerve sheath tumors [MPNST], 1 triton tumor) and 6 cases of rhabdomyosarcoma (RMS). The prevalence of NF1 observed during the study period was 43% in the MPNST population and 1% in the RMS group.RESULTSMost patients with neurogenic sarcomas had large, invasive tumors. Five‐year event‐free and overall survival rates were 19% and 28%, respectively. Two of 16 patients with evaluable disease responded to chemotherapy. All 6 RMS patients were ≤3 years old and had embryonal subtype, 5 of 6 arising in the genitourinary tract or pelvis (paravesical); 4 were alive in first remission at the time of the analysis, 1 was alive in second remission after a local recurrence, and 1 died of disease.CONCLUSIONSThe occurrence of STS in pediatric patients with NF1 syndrome in Italy is discussed, confirming that NF1 patients have a high risk of developing STS, and particularly MPNST, often with an aggressive clinical presentation and poor outcome. Cases of RMS tended to have particular features (early age, embryonal histotype, genitourinary site) and their outcome seemed to resemble that of the general RMS population. Cancer 2007 © 2007 American Cancer Society.
Functional activity in vivo of effector T cell populations III. Protection against Moloney murine sarcoma virus (M‐MSV)‐induced tumors in T cell deficient mice by the adoptive transfer of a M‐MSV‐specific cytolytic T lymphocyte clone
Authors: Cerundolo Vincenzo , Lahaye Thierry , Horvath Clotilde , Zanovello Paola , Collavo Dino , Engers Howard D. 
Published: March 2007

AbstractThe functional activity of Moloney murine sarcoma virus (M‐MSV)‐specific T lymphocytes in vivo was assayed by the i.v. injection of virus‐specific T lymphocytes into T cell‐deficient “B mice”. Virus‐specific T lymphocytes generated in mixed lymphocyte tumor cell cultures were transferred i.v. into syngeneic “B mice” injected simultaneously at a distant site with the virus. These experiments indicated that a low dose (1 × 106 cultured cells) of infused lymphocytes can afford protection. To define the T lymphocyte subpopulation which was active, Lyt‐2+ lymphocytes were selected by “panning” on plastic petri dishes coated with anti‐Lyt‐2 monoclonal antibody, and Lyt‐2− lymphocytes selected by treatment with anti‐Lyt‐2 monoclonal antibody and complement. The results indicated that a Lyt‐2+ lymphocyte‐enriched population was more efficient in conferring protection against M‐MSV‐induced tumors.To investigate if cytolytic T lymphocytes (CTL) alone had a protective effect, a M‐MSV‐specific CTL clone was transferred in the same model system. The results demonstrated that a M‐MSV‐specific CTL clone prevented M‐MSV‐induced tumor growth and also induced the destruction of syngeneic Moloney murine leukemia virus (M‐MuLV)‐induced MBL‐2 leukemic cells in the peritoneal cavity. However, the cell dose required to obtain protection using a CTL clone was higher than that which was effective when mixed lymphocyte tumor cell culture cells were used.To assess the ability of the transferred cells to home and to repopulate the lymphoid organs of the “B mice”, the frequency of virus‐specific CTL precursors in the spleen was evaluated by limiting dilution analysis. The results indicated that lymphocytes from mixed lymphocyte tumor cell cultures can be recovered from the spleens of “B mice” injected i.v. 25 days earlier. On the contrary, following the transfer of an active CTL clone, a very low frequency (< 1/200000 cells) of virus‐specific CTL precursors was present in the spleens of recipient animals. The same M‐MSV‐specific CTL clone did not yield protection against M‐MSV‐induced tumors or MBL‐2 leukemic cells when injected i.v. into M‐MuLV tolerant mice.
Involvement of the CD4 molecule in a post‐activation event on T cell proliferation
Authors: Carrera Ana C. , Sanchez‐Madrid Francisco , Lopez‐Botet Miguel , Bernabeu Carmelo , De Landazuri Manuel O. 
Published: March 2007

AbstractA monoclonal antibody (mAb) directed to a human leukocyte 55‐kDa cell surface molecule with identical cellular distribution and biochemical properties to the CD4 was able to inhibit T cell proliferation induced either in a mixed lymphocyte culture or by activation with mAb anti‐CD3, anti‐CD2 or phytohemagglutinin. The inhibitory effect of anti‐CD4 was observed in the absence of monocytes and was directly exerted on T4+ cells.This effect on cellular proliferation appears to be due to an inhibition of a post‐activation event since (a) the rise of cytoplasmic Ca2+ after activation with anti‐CD3 mAb is not affected by the presence of anti‐CD4 and (b) the proliferation that occurs after an activation pulse of 3 h with ionophore and phorbol myristate acetate can be inhibited when the anti‐CD4 is added after the pulse period. Kinetic studies demonstrated that the inhibition of cellular proliferation by anti‐CD4 mAb was observed even if the antibody was added as late as 18–24 h after the initiation of the culture. The effect of this blocking anti‐CD4 mAb on the interleukin (IL) 2/IL 2 receptor signalling pathways was also examined. The presence of anti‐CD4 slightly affected the production of IL 2. In fact, addition of exogenous recombinant IL 2 at the initiation of the cultures did not restore the proliferative response. However, anti‐CD4 had a strong inhibitory effect on the expression of IL 2 receptors as analyzed by direct immunofluorescence cytometry. Taken together, these results indicate that the binding of the anti‐CD4 mAb to T cells interferes with a late metabolic step being capable of abolishing the proliferative activity of fully activated cells.