bluuebunny/crossref_metadata_2025_split huggingface dataset:
Scavenger Receptor Class B Type I Protein as an Independent Predictor of High-Density Lipoprotein Cholesterol Levels in Subjects with Hyperalphalipoproteinemia
Authors: West Michael , Greason Erin , Kolmakova Antonina , Jahangiri Anisa , Asztalos Bela , Pollin Toni I. , Rodriguez Annabelle 
Published: January 2009

AbstractContext: In mice, scavenger receptor class B, type I (SR-BI) receptor protein deficiency is associated with elevated high-density lipoprotein (HDL)-cholesterol (HDL-C) levels.Objective: Our objective was to determine the relationship between SR-BI protein and HDL-C levels in humans.Design: This was a prospective study of adults with hyperalphalipoproteinemia. Fasting blood was obtained for lipid and lipoprotein measurement, genomic DNA, and monocyte-derived macrophages. SR-BI protein levels were measured by Western blots, and SR-BI activity was measured by cholesteryl ester (CE) uptake of each donor’s radiolabeled HDL with their monocyte-derived macrophages, or by degradation and specific cell association of dual-labeled HDL in vitro.Setting: The study was performed in a tertiary university teaching hospital.Results: The mean age was 57.2 ± 10.9 yr (n = 65). SR-BI protein levels were inversely associated with HDL-C levels (P &lt; 0.002), HDL particle size (P &lt; 0.05), and positively associated with CE uptake (P &lt; 0.004); there was no association with plasma apolipoprotein levels. SR-BI protein levels (P = 0.01) were independent predictors of HDL-C levels. Subjects who were carriers of the A allele for the rs4238001 (glycine to serine at position 2) polymorphism [single nucleotide polymorphism (SNP)] had lower SR-BI protein levels (P = 0.01), whereas carriers of the C allele for the rs2278986 SNP also had lower SR-BI protein levels (P = 0.02). Body mass index (P = 0.05), rs4238001 (P = 0.01), and rs2278986 (P = 0.01) SNPs were independent predictors of SR-BI protein levels. In vitro studies of murine macrophages stably expressing the glycine to serine at position 2 SNP showed less degradation (P &lt; 0.0004) and specific cell association (P &lt; 0.0004) of [125I, 3H]-CE-labeled HDL.Conclusions: SR-BI protein has an independent effect on HDL-C levels in women with hyperalphalipoproteinemia. Two SNPs were significantly associated with lower SR-BI protein levels.
The role of deception in P300 memory detection
Authors: Verschuere Bruno , Rosenfeld J. Peter , Winograd Michael R. , Labkovsky Elena , Wiersema Roeljan 
Published: January 2009

Purpose. P300 memory detection test is a neuroscientific procedure to assess memories stored in the brain. P300 memory detection can and is currently applied to assess criminal suspects on recognition of critical crime information. Contrasting memory detection with lie detection, researchers have argued that P300 memory detection does not involve deception. We empirically investigated this argument by manipulating deception between groups.Methods. Thirty‐four community volunteers participated in a P300 memory detection test, answering either deceptively (deceptive condition) or truthfully (truth condition) to their own name.Results. P300 memory detection was significant in the truth condition, indicating that deceptive responding is not a prerequisite for valid P300 memory detection. However, there were clear indications that deceptive responding improved memory detection.Conclusions. Deception seems involved in the P300 memory detection test; and deceptive responding may add to test accuracy.
Effects of Cooling Rate Fluctuation on Cooling and Transformation Behavior of Steel upon Direct Quenching
Authors: Luo Xinmin , Li Jiankang 
Published: January 2009

Abstract
TTT-diagrams and CCT-diagrams, which are derived from isothermal Newtonian cooling conditions, have been traditionally used for developing and examining heat treating processes. However, actual cooling and transformation behavior of a steel part upon direct quenching is controlled by a number of factors. When examining actual quenching practice, it is important to correlate cooling performance of the quenchant and the cooling and transformational behavior of steel, especially if there is a variation of cooling rate during the quenching process. This behavior is very difficult to detect by a cooling curve method only. Theoretically, dynamic measurement may be used to detect any transient, even a very small variance in thermoelectric potential. Thus, measurement of thermoelectric potential may provide more detail and insight into the quenching process than a simple temperature-time response as reflected by conventional cooling curve analysis. Therefore, to detect dynamic cooling and steel transformation behavior upon direct quenching, an experiment was conducted using plain carbon steel rods of ⊘5–8 mm diameter with a thermocouple located at the geometric center of the bar. Cooling rate variation upon direct quenching was characteristically demonstrated by dynamic cooling curves. The smaller the diameter of the rods, the more drastic the quench severity and the more sensitive the cooling curve. By comparison to an appropriate temperature-time-transformation (TTT)-diagram or continuous cooling transformation (CCT)-diagram, the cooling process and the transformation behavior of steel upon direct quenching was analyzed with respect to the cooling rate fluctuation obtained in this experiment. The presence of lamellar pearlite of 0.70 % carbon steel wire substantiated the effects of cooling methods and quenchant on the cooling and transformation behavior of the steel wire upon direct quenching. Dynamic measurements revealed new and helpful details related to the direct quenching process.
The structural properties of amides and imides as hydrogen storage materials
Authors: Ichikawa Takayuki , Isobe Shigehito 
Published: January 2009

Abstract
We discuss crystal structure of amides and imides, which are focusing on promising hydrogen storage materials. They are ionic crystal with anion of (NH2)– or (NH)2– and cation of Li+, Na+, Mg2+, Ca2+, and so forth. We also discuss reaction mechanisms on hydrogen ab/desorption of amide/imide hydrogen storage materials.
RicePi5-Mediated Resistance toMagnaporthe oryzaeRequires the Presence of Two Coiled-Coil–Nucleotide-Binding–Leucine-Rich Repeat Genes
Authors: Lee Sang-Kyu , Song Min-Young , Seo Young-Su , Kim Hye-Kyung , Ko Seho , Cao Pei-Jian , Suh Jung-Pil , Yi Gihwan , Roh Jae-Hwan , Lee Sichul , An Gynheung , Hahn Tae-Ryong , Wang Guo-Liang , Ronald Pamela , Jeon Jong-Seong 
Published: January 2009

AbstractRice blast, caused by the fungus Magnaporthe oryzae, is one of the most devastating diseases of rice. To understand the molecular basis of Pi5-mediated resistance to M. oryzae, we cloned the resistance (R) gene at this locus using a map-based cloning strategy. Genetic and phenotypic analyses of 2014 F2 progeny from a mapping population derived from a cross between IR50, a susceptible rice cultivar, and the RIL260 line carrying Pi5 enabled us to narrow down the Pi5 locus to a 130-kb interval. Sequence analysis of this genomic region identified two candidate genes, Pi5-1 and Pi5-2, which encode proteins carrying three motifs characteristic of R genes: an N-terminal coiled-coil (CC) motif, a nucleotide-binding (NB) domain, and a leucine-rich repeat (LRR) motif. In genetic transformation experiments of a susceptible rice cultivar, neither the Pi5-1 nor the Pi5-2 gene was found to confer resistance to M. oryzae. In contrast, transgenic rice plants expressing both of these genes, generated by crossing transgenic lines carrying each gene individually, conferred Pi5-mediated resistance to M. oryzae. Gene expression analysis revealed that Pi5-1 transcripts accumulate after pathogen challenge, whereas the Pi5-2 gene is constitutively expressed. These results indicate that the presence of these two genes is required for rice Pi5-mediated resistance to M. oryzae.
Cystic fibrosis and pregnancy
Authors: Goddard Julie , Bourke Stephen J 
Published: January 2009

Cystic fibrosis is the most common inherited life‐threatening disease.
Advances in treatment have led to increased life expectancy.
Increasing numbers of women with cystic fibrosis are choosing to embark on pregnancy; for most, it does not appear to have a detrimental effect on long‐term health.
Pregnancy outcomes are generally good but 20% of women do not live to see their child's tenth birthday.

Learning objectives:

To be aware of the effects of cystic fibrosis on pregnancy.
To understand the importance of preconceptual counselling.
To appreciate that pregnancy management requires a multidisciplinary approach.

Ethical issues:

Should doctors advise women with cystic fibrosis and poor lung function against undertaking pregnancy?
Should assisted reproductive technology be available for women with life‐limiting diseases?

Please cite this article as: Goddard J, Bourke SJ. Cystic fibrosis and pregnancy. The Obstetrician & Gynaecologist 2009;11:19–24.
Surrogate pregnancy: an essential guide for clinicians
Authors: Bhatia Kalsang , Martindale Elizabeth A , Rustamov Oybek , Nysenbaum Anthony M 
Published: January 2009

The incidence of surrogacy is rising.
Literature on associated obstetric risks is scarce and caution must be exercised when labelling surrogate pregnancies as low risk.
Although obstetricians’ responsibilities lie with the surrogate mother, they must ensure her wishes do not conflict with the best interests of the baby.
Prepregnancy counselling is the key to a successful surrogacy arrangement.

Learning objectives:

To gain an awareness of the different types of surrogacy.
To understand the law surrounding surrogacy.
To learn about antenatal, intrapartum and postpartum care in surrogacy.

Ethical issues:

When the surrogate mother's wishes and the interests of the child conflict, do obstetricians have the right to discuss this with the commissioning parents without her consent?
When should obstetricians seek ethical and legal support?

Please cite this article as: Bhatia K, Martindale EA, Rustamov O, Nysenbaum AM. Surrogate pregnancy: an essential guide for clinicians. The Obstetrician & Gynaecologist 2009;11:49–54.
Multiprofessional ‘fire‐drill’ training in the labour ward
Authors: Siassakos Dimitrios , Crofts Joanna , Winter Cathy , Draycott Timothy ,   on behalf of the SaFE Study Group
Published: January 2009

Regular multiprofessional rehearsals of the management of obstetric emergencies have been recommended since 1997.
In‐house training is cheap and associated with improved outcomes.
Teamwork failure is associated with poor obstetric outcome but aviation‐based team training is not a panacea: we may need to develop and evaluate obstetric‐specific interventions.

Learning objectives:

To comprehend the importance of rehearsals in the labour ward.
To understand the components of successful ‘fire‐drills’.

Ethical issues:

Excessive focusing on the processes of training can lead to neglect of teamworking and prevent sustainable differences in outcomes.
Entrenched negative attitudes to risk management processes can reduce the impact of training.

Please cite this article as: Siassakos D, Crofts J, Winter C, Draycott T. Multiprofessional ‘fire‐drill’ training in the labour ward. The Obstetrician & Gynaecologist 2009;11:55–60.
Nature and origin of the Triassic volcanism in Albania and Othrys: a key to understanding the Neotethys opening?
Authors: Monjoie Philippe , Lapierre Henriette , Tashko Artan , Mascle Georges H. , Dechamp Aline , Muceku Bardhyl , Brunet Pierre 
Published: January 2009

AbstractTriassic volcanic rocks, stratigraphically associated with pelagic or reef limestones, are tectonically juxtaposed with Mesozoic ophiolites in the Tethyan realm. From the central (Dinarides, Hellenides) and eastern Mediterranean (Antalya, Troodos, Baër Bassit) to the Semail nappes (Oman), they occur either associated to the tectonic sole of the ophiolitic nappes or as a distinct tectonic pile intercalated between the ophiolites and other underthrust units. In the Dinaro-Hellenic belt, the Pelagonian units represent the lower plate, which is underthrust beneath the ophiolites. Middle to Late Triassic volcanic sequences are interpreted as the eastern flank of the Pelagonian platform and are therefore considered as a distal, deep-water part of the Pelagonian margin.The Triassic volcanics from Albania and Othrys are made up of basaltic pillowed and massive flows, associated locally with dolerites and trachytes. New elemental, Nd and Pb isotopic data allow to recognize four types of volcanic suites: (1) intra-oceanic alkaline and tholeiitic basalts, (2) intra-oceanic arc-tholeiites, (3) back-arc basin basalts, (4) calc-alkaline mafic to felsic rocks. Nd and Pb isotopic initial ratios suggest that the within-plate volcanic rocks were derived from an enriched oceanic island basalt type mantle source, devoid of any continental crustal component. The lower εNd value of the trachyte could be due to assimilation of oceanic altered crust or sediments in a shallow magma chamber. Island arc tholeiites and back-arc basin basalts have a similar wide range of εNd. The absence of Nb negative anomalies in the back-arc basin basalts suggests that the basin floored by these basalts was wide and mature. The high Th contents of the island arc tholeiites suggest that the arc volcanoes were located not far away from the continental margin.Albania and Othrys volcanics contrast with the Late Triassic volcanism from eastern Mediterranean (SW Cyprus, SW Turkey), which displays solely features of oceanic within plate suites. The presence of back-arc basin basalts associated with arc-related volcanics in Central Mediterranean indicates that they were close to a still active subduction during the Upper Triassic, while back-arc basins developed, associated with within-plate volcanism, leading to the NeoTethys opening.
Temperature Effects in Up-Conversion Processes of Erbium - Ytterbium Doped Oxyfluoride Silicate Glass
Authors: Grube J. , Sarakovskis A. , Dimitrocenko L. , Springis M. 
Published: January 2009

Temperature Effects in Up-Conversion Processes of Erbium - Ytterbium Doped Oxyfluoride Silicate GlassEr3+- Yb3+doped oxyfluoride glass has been synthesized and investigated. It was found that the up-conversion spectrum of the sample excited by a 980 nm laser diode is highly dependent on the temperature of the sample. Using fluorescence intensity ratio technique the green up-conversion emissions at 525 nm and 550 nm were studied in detail in the temperature range 120-600 K. The potential applicability of the obtained results in the field of the temperature sensing is discussed.
Sulfonated Poly(Ether-Ether-Ketone) Polymer Membranes for Fuel Cells
Authors: Hodakovska J. , Kleperis J. 
Published: January 2009

Sulfonated Poly(Ether-Ether-Ketone) Polymer Membranes for Fuel CellsIn the work, sulfonated poly(ether-ether-ketone) (SPEEK) ionomers were synthesized using an original (submitted for patent) and simple method. The resulting membranes were tested to determine parameters that are important for the use of this material in fuel cells (water absorption, sulfonation degree, conductivity, etc.). The thermo-gravimetric analysis has shown a good thermal stability in the range from RT to 200-220 °C, and two characteristic regions of weight loss - 7.4% at ~140 °C (reversible water loss) and 10.3% at 200-220 °C (due to polymer degradation when cross-linked polymer chains permanently break down and their SO3H-groups are lost). The conductivity values obtained by the through-plane measurements of SPEEK membranes were 12 mS/cm at RT and 23 mS/cm at 80 °C.
Breeding and Demographic Parameters and Range Expansion of the Common Rosefinch (Carpodacus erythrinus)
Authors: Payevsky Vladimir 
Published: January 2009

Breeding and Demographic Parameters and Range Expansion of the Common Rosefinch (Carpodacus erythrinus)
Breeding biology, age structure and other population parameters of the Common Rosefinch, collected on the Courish Spit of the Baltic Sea, are presented. The results are compared with similar population characteristic in different parts of the range. All materials, especially the proportion of breeding yearling males, are discussed in connection with the process of range expansion of the species. The expectation of greater proportion of yearling males in new areas did not proved.
Time for Municipal Elder Rights Law: An Anglo-Canadian Perspective
Authors: Doron Israel 
Published: January 2009

RÉSUMÉEn cette ère de mondialisation et de privatisation, les gouvernements locaux et les municipalités cherchent à définir leur rôle et leur place dans la société. Dans une société vieillissante comme le Canada, faire valoir que les droits juridiques des aînés devraient faire partie du fondement juridique des obligations municipales n'est pas simple. Il est moins compliqué de soutenir que sans une machine centralisée efficace les problèmes sociaux et environnementaux demeureront insolubles ou non traités.Le présent article propose une idée différente de la place de l'administration municipale au Canada. L'article vise à présenter un argument original en politique juridique: il est temps que les communautés locales et les gouvernements locaux au Canada utilisent leur droits fondamentaux pour adopter des règlements locaux qui définissent et établissent les droits des citoyens âgés. L'oargument maintient que les municipalités locales détiennent le pouvoir légal et le potentiel social leur permettant d'oapporter une contribution importante à la promotion des droits des aînés dans la sphère politique, et que ce pouvoir a été jusqu'oà maintenant négligé.L'oarticle soutient l'oargument de trois façons: 1) une analyse empirique des règlements existants dans diverses municipalités du Canada; 2) une analyse socio-légale des avantages de la loi municipale comme outil de changement social; et 3) une analyse par cas d'oune récente réforme des lois municipales dans la province de la Colombie-Britannique.
Reversible Storage of Lithium in a Rambutan‐Like Tin–Carbon Electrode
Authors: Deng Da , Lee Jim Yang 
Published: January 2009

Abstract„Fruchtige“ Elektroden: Eine einfache Bottom‐up‐Methode wurde zum Aufbau von Rambutan‐förmigen Zinn‐Kohlenstoff(Sn@C)‐Nanoarchitekturen verwendet (siehe Schema; grün Sn), um die reversible Speicherung von Lithium in Zinnmaterialien zu verbessern. Der Wachstumsmechanismus der birnenförmigen Härchen wird untersucht.magnified image
Proteomic Analysis of Plasma Membrane Vesicles
Authors: Bauer Brigitte , Davidson Max , Orwar Owe 
Published: January 2009

AbstractEine einfache und skalierbare Methode, die das Sammeln, die Reinigung und das Prozessieren auf einem Chip von Säuger‐Plasmamembranvesikeln (PMVs) vorsieht, wurde für die Proteomanalyse optimiert. Nach der Immobilisierung von PMVs auf einer Mikrofluidikzelle werden die eingebetteten Membranproteine proteolytisch abgebaut, und die erhaltenen Peptide konnten durch LC‐MS/MS analysiert werden. Über 93 % der detektierten Proteine stammten aus der Plasmamembran.magnified image
Protein‐Functionalized Synthetic Antiferromagnetic Nanoparticles for Biomolecule Detection and Magnetic Manipulation
Authors: Fu Aihua , Hu Wei , Xu Liang , Wilson Robert J. , Yu Heng , Osterfeld Sebastian J. , Gambhir Sanjiv S. , Wang Shan X. 
Published: January 2009

AbstractDie direkte Proteinfunktionalisierung ergibt synthetische antiferromagnetische Nanopartikel mit hoher chemischer Spezifität und vielfältigen Funktionen. Diese Nanopartikel‐Protein‐Konjugate wirken als verbesserte magnetische Markierungen für biologische Analysen und reagieren in einstellbarer Weise auf kleine äußere Magnetfeldgradienten, sodass sich die Bewegung einzelner Nanopartikel verfolgen lässt.magnified image
Electronic Absorption Spectra and Redox Properties of C Type Cytochromes in Living Microbes
Authors: Nakamura Ryuhei , Ishii Kazuyuki , Hashimoto Kazuhito 
Published: January 2009

AbstractShewanella ist eine elektrogene Mikrobe, die beträchtliche Mengen an c‐Cytochromen enthält (ca. 0.5 mM). Durch diese Eigenschaft gelingt es, die optischen Absorptionsspektren der zellmembranassoziierten Proteine während extrazellulärer respiratorischer Elektronentransferreaktionen in vivo zu verfolgen. Es ergeben sich signifikante Unterschiede zu Resultaten, die mit gereinigten Proteinen in vitro erhalten wurden.magnified image
A Pyrrolysine Analogue for Protein Click Chemistry
Authors: Fekner Tomasz , Li Xin , Lee Marianne M. , Chan Michael K. 
Published: January 2009

AbstractMithilfe des UAG‐Codons wurde ein Pyrrolysin‐Analogon mit terminaler Alkinfunktion ortsspezifisch in rekombinantes Calmodulin (CaM) eingebaut. Das resultierende Protein wurde über eine Kupfer(I)‐katalysierte Klick‐Reaktion mit der Azidgruppe eines Farbstoffs verknüpft. Die anschließende Anwendung einer orthogonalen Cystein‐Markierungsmethode ergab mit zwei unterschiedlichen Fluorophoren markiertes CaM für FRET‐Studien.magnified image
A Palladium(II)‐Catalyzed Synthesis of Spiroacetals through a One‐Pot Multicomponent Cascade Reaction
Authors: Barluenga José , Mendoza Abraham , Rodríguez Félix , Fañanás Francisco J. 
Published: January 2009

AbstractFunktionalisierte Spiroacetale sind durch eine Dreikomponentenkupplung von Pentinolderivaten, Salicylaldehyden und Aminen in Gegenwart katalytischer Mengen eines Palladium(II)‐Komplexes zugänglich (siehe Schema). Alternativ können Spiroacetale mit Sauerstoffsubstituenten erhalten werden, wenn man Orthoester als dritte Komponente einsetzt.magnified image
Receptor‐Mediated Targeting of Cathepsins in Professional Antigen Presenting Cells
Authors: Hillaert Ulrik , Verdoes Martijn , Florea Bogdan I. , Saragliadis Anastasios , Habets Kim L. L. , Kuiper Johan , Van Calenbergh Serge , Ossendorp Ferry , van der Marel Gijsbert A. , Driessen Christoph , Overkleeft Hermen S. 
Published: January 2009

AbstractSpeziell für professionelle Zellen: Ein Mannosid‐DCG‐04‐Analog mit Fluoreszenzmarkierung (siehe Struktur) wurde nach einem modularen Verfahren entworfen und synthetisiert. Die Aufnahme der Sonde in professionelle antigenpräsentierende Zellen und die anschließende Markierung von Cathepsinen waren vom Mannoserezeptor abhängig.magnified image
Enantiomerically Pure Chiral {Fe28} Wheels
Authors: Zhang Zhi‐Ming , Li Yang‐Guang , Yao Shuang , Wang En‐Bo , Wang Yong‐Hui , Clérac Rodolphe 
Published: January 2009

AbstractEisenräder kommen groß raus: Zwei enantiomerenreine radförmige {Fe28}‐Aggregate wurden in einer Acetatpufferlösung aus Eisen(III)‐Ionen und chiralen Tartratliganden hergestellt (siehe Bild). Die Verbindungen sind die größten bisher isolierten chiralen Eisen(III)‐Aggregate.magnified image
Protein‐Functionalized Synthetic Antiferromagnetic Nanoparticles for Biomolecule Detection and Magnetic Manipulation
Authors: Fu Aihua , Hu Wei , Xu Liang , Wilson Robert J. , Yu Heng , Osterfeld Sebastian J. , Gambhir Sanjiv S. , Wang Shan X. 
Published: January 2009

AbstractDirect protein functionalization provides synthetic antiferromagnetic nanoparticles with high chemical specificity and multifunctionality. These nanoparticle–protein conjugates function as improved magnetic labels for biological detection experiments, and exhibit tunable responses to a small external magnetic field gradient, thus allowing the observation of distinctive single nanoparticle motion.magnified image
Size‐Dependent Ordering of Liquid Crystals Observed in Polymeric Capsules with Micrometer and Smaller Diameters
Authors: Gupta Jugal K. , Sivakumar Sri , Caruso Frank , Abbott Nicholas L. 
Published: January 2009

AbstractMade to order: Aqueous dispersions of polymer‐encapsulated liquid crystal (LC) droplets were synthesized with precise interfacial chemistry and sizes in the micrometer‐to‐sub‐micrometer range. Size‐dependent changes in LC ordering could be observed. Study of the competition between size and interfacial chemistry on LC ordering enables size‐dependent properties of LC droplets to be exploited in applications such as photonics and sensing.magnified image