bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lactation following conservation surgery and radiotherapy for breast cancer
Authors: Varsos George , Yahalom Joachim 
Published: February 2007

AbstractA 38‐year‐old woman with early stage invasive breast cancer was treated with wide excision of the tumor, axillary lymph node dissection, and breast irradiation. Three years later, she gave birth to a normal baby. She attempted breast feeding and had full lactation from the untreated breast. The irradiated breast underwent only minor changes during pregnancy and postpartum but produced small amounts of colostrum and milk for 2 weeks postpartum. There are only a few reports of lactation after breast irradiation. These cases are reviewed, and possible factors affecting breast function after radiotherapy are discussed. Because of scant information available regarding its safety for the infant, nursing from the irradiated breast is not recommended.
Primary carcinoma of the gallbladder
Authors: Chao Tzu‐Chieh , Greager John A. 
Published: February 2007

AbstractSeventy‐four patients with primary carcinoma of the gallbladder, diagnosed over 18 years from 1969 to 1987, were studied retrospectively. The most common presenting complaint was abdominal pain, followed by jaundice and weight loss. Surgery was performed in 61 patients and of these patients, only two had accurate preoperative diagnosis which was made by ultrasonography. Twelve of the 13 patients who were treated medically had the disease diagnosed at autopsy. One of the 13 patients had the diagnosis of gallbladder cancer by the findings of ultrasonography and abdominal computed tomography (CT) scanning. The resectability of the surgically managed group was 36.1%, and the majority of patients with advanced tumors (82.2%) were deemed unresectable. The most common histologic type was adenocarcinoma. Liver was the organ most commonly invaded (76.5%) by direct extension and/or metastases, followed by regional lymph nodes (52.9%). The overall 5‐year survival rate was 5.4%. A high index of suspicion of the disease, intraoperative examination of gallbladder specimen, and earlier, more aggressive surgical treatment may improve patient survival.
Prognosticators of second‐look laparotomy findings in patients with epithelial ovarian cancer
Authors: Ayhan Ali , Yarali Hakan , Develioǧlu Osman , Üren Aykut , Özyilmaz Filiz 
Published: February 2007

AbstractPrognosticators of outcome at second‐look laparotomy (SLL) were evaluated in 49 patients with epithelial ovarian carcinoma undergoing SLL. Residual tumor volume was found to be the most significant prognosticator of outcome, with initial tumor stage being of secondary importance. Grade of tumor played no role in outcome at SLL. The results of the study led us to the conclusion that the second‐look procedure may be safely omitted in stage I patients. The importance of optimal cytoreduction during primary surgery was stressed.
Primary lymphoma of bone: A clinicopathologic study of 25 cases reported over 10 years
Authors: Desai Sangeeta , Jambhekak Nikmala A. , Soman Chitralekha S. , Advani Suresh H. 
Published: February 2007

AbstractTwenty‐five cases of primary lymphoma of bone (PLB) reported over a 10‐year period were reviewed. The presenting symptom was related to involvement of a single bone with or without regional nodal disease. None showed dissemination of lymphoma in the subsequent six months. Patients affected were 7‐65 years of age. An equal predilection for the axial and appendicular skeleton was noted. Histologically, the commonest subtype was diffuse histiocytic lymphoma (DHL, 17 cases), whereas four were poorly differentiated lymphocytic (PDL) type and another four were unclassifiable. Follow‐up was available in 18 out of 25 patients for periods ranging from 7 months to 8 years. On clinicopathologic correlation we found that 75% of disease‐free patients had a DHL whereas 60% of those alive with disease had a PDL. This study reiterates the view that PLB has a good prognosis and the DHL subtype is especially amenable to complete eradication.
Conservative management of intraductal carcinoma (DCIS) of the breast
Authors: Fisher Edwin R. , Leeming Rosemary , Anderson Stewart , Redmond Carol , Fisher Bernard 
Published: February 2007

AbstractSeventy‐six patients with intraductal carcinoma (DCIS) of the breast have been observed for 83 months (range 50‐141) following treatment by lumpectomy (L) only (21), L and breast irradiation (XRT) (27), or mastectomy (28). All represented examples of DCIS retrieved after pathologic examination of a much larger cohort of patients with stage I and II invasive breast cancer enrolled in NSABP protocol 6. Local breast recurrences were similar for women with DCIS and those from this cohort at a similar period of follow‐up with invasive cancer treated by L only (43% vs. 39%) and L + XRT (7% vs. 10%). The presence of moderate/ marked comedonecrosis was suggestively related to local breast recurrence (P= .07). This latter was significantly reduced for patients receiving post L XRT (P= .01). All local breast recurrences in this study and 29 of 31 recorded by others occurred at or close to the site of extirpation of the index cancer minimizing multicentricity as a contraindication for the conservative surgical treatment of DCIS. Survival rates which were similar for patients with DCIS regardless of form of local treatment were better than that observed for negative node patients with invasive cancer enrolled in protocol 6. Thus, DCIS is a less, not more, ominous disease than invasive cancer. This and other features of its natural history indicate that it would be a contradiction to treat invasive cancer but not DCIS conservatively.
Angiolymphoid hyperplasia with eosinophilia (Kimura's disease): Report of a large‐sized lesion
Authors: Jambhekar Nirmala A. , Borges Anita M. , Saxena Romil , Parikh Dipak M. , Soman Chitralekha S. 
Published: February 2007

AbstractAngiolymphoid hyperplasia with eosinophilia (ALHE) is an uncommon lesion with a predilection for skin of the head and neck region. It usually presents as one or a few smooth‐surfaced nodules which are often asymptomatic. Histologially the nodules reveal two components: abnormal proliferating vessels and a cellular infiltrate consisting of lymphocytes and eosinophils, involving both the dermis and the subcutaneous tissue. A case is presented of an unusually large recurrent lesion on the scalp.
In vitro response of a human colon tumor xenograft and a lung adenocarcinoma cell line to α‐difluoromethylornithine alone and in combination with 5‐fluorouracil and doxorubicin
Authors: Zirvi Karimullah A. , Atabek Umur 
Published: February 2007

AbstractWe have investigated effects of α‐difluoromethylornithine (DFMO), both as a single agent and in combination with 5‐fluorouracil (5‐FU) against a human colon tumor xenograft (T6) grown as primary tissue culture in serum‐free medium and in combination with doxorubicin (DX) against a human lung adenocarcinoma cell line (A549). DFMO showed a dose‐dependent growth‐inhibitory effect against human colon tumor xenograft and lung adenocarcinoma cells. Growth‐inhibitory activity of DFMO against T6 cells was reversed completely when the cells were treated simultaneously with putrescine (PU) (10−6 M) and DFMO (10−3 M). When 5‐FU and DFMO were used in combination against T6 cells, no antagonism or synergism between the two drugs was seen. However, in the case of A549 cells, when DFMO was used in combination with DX, there was a consistent increase in growth inhibition that surpassed the inhibition of either agent given alone.
Is there an established role for immunotherapy for any of our surgical cancers?
Authors: Elias E. George 
Published: February 2007

AbstractDespite major advances in the management of the patient and in surgical and radiation therapy, cancer deaths continue to occur secondary to widespread metastases. Therefore, systemic treatments in the form of chemotherapy, hormonal therapy, and immunotherapy are constantly being investigated, both as adjuvant to the local therapeutic modalities, as well as therapeutically for unresectable metastases. While the first two systemic modalities have established themselves in cancer management, immunotherapy has been lagging behind for several reasons.
Distribution of histologic subtypes and sex ratio in various primary sites of lymphocytic lymphoma
Authors: Ohsawa Masahiko , Aozasa Katsuyuki , Saeki Kazunori , Tsujimura Takahiro , Tamai Masamitsu , Kawano Kiyoshi 
Published: February 2007

AbstractTo examine the distribution of histologic subtypes and sex ratio in each primary site of lymphoma, 1, 169 histologically proven cases of lymphocytic lymphoma were analyzed. The location of tumor was nodal in 615(53%) and extranodal in 517(44%), patients with the gastrointestinal tract being the most common. The incidence was predominantly in males for all histologic types and in nodal and extranodal sites, except for a predominance of females in extranodal lymphoplasmacytic(Lp‐cytic), lymphoplasmacytoid(Lp‐cytoid) tumors. Frequency of the Lp‐cytic/Lp‐cytoid type among all types of lymphoma in females was about 2.7 times more frequent in extranodal than in nodal sites. The most striking example was thyroid lymphoma in which the frequency of Lp‐cytic/Lp‐cytoid type was 36% in female and 0% in male patients. Including this type of lymphoma, frequency of low grade lymphoma in females was higher in extranodal sites than in nodal sites.
Papillary thyroid cancer and its surgical
Authors: Noguchi Masakuni , Earashi Mitsuharu , Kitagawa Hirohisa , Ohta Nagayoshi , Thomas Michael , Miyazaki Itsuo , Mizukami Yuji , Michigishi Takatoshi 
Published: February 2007

AbstractThe surgical management in papillary thyroid cancer has been highly controversial. In the Department of Surgery (II), Kanazawa University Hospital, the surgical management especially for cervical lymph node metastases has changed since 1973 from a conservative approach to an aggressive one. In order to determine whether an aggressive approach is warranted, a retrospective multivariate analysis was carried out on 106 cases of papillary thyroid cancer. The patients have been followed for 10–28 years. Multivariate analysis was conducted following Cox's model. By this analysis, aggressive management appeared to have no impact on survival or relapse‐free survival. However, age, sex, tumor size, and cervical lymphadenopathy were confirmed to be important prognostic factors in survival and/or relapse‐free survival. © 1992 WiIey‐Liss, Inc.
Alpha‐fetoprotein production by hepatocellular carcinoma is prognostic of poor patients survival
Authors: Izumi Ryohei , Shimizu Kohichi , Kiriyama Masato , Hashimoto Tetsuo , Urade Masaaki , Yagi Masato , Mizukami Yuji , Nonomura Akitaka , Miyazaki Itsuo 
Published: February 2007

AbstractImmunohistochemistry using the avidinbiotinperoxidase complex method was performed to study the production of alphafetoprotein (AFP) in hepatocellular carcinoma (HCC) tissue specimens which were obtained surgically. The relationship between staining for AFP and serum AFP levels or pathological findings was examined. The prognosis of the patients with HCC who underwent curative hepatic resections was studied with respect to the staining for AFP in their tumors. The mean serum AFP level in patients with positive AFP staining was significantly higher than in those with negative AFP staining. No significant relationship was found between AFP positivity and tumor size, tumor encapsulation, degree of vascular invasion, or the histological differentiation grade of the tumor. The patients with AFP‐positive carcinomas had a poorer prognosis than did those with AFP‐negative carcinomas (5‐year survival rate of AFP‐positive and negative groups were 26.7% and 56.5%, respectively). © 1992 Wiley‐Liss, Inc.
Diagnostic utility of DNA content flow cytometry in follicular neoplasms of the thyroid
Authors: Harlow Seth P. , Duda Rosemary B. , Bauer Kenneth D. 
Published: February 2007

AbstractPreoperative diagnosis of follicular carcinoma of the thyroid remains a clinical challenge. This study determined the DNA content parameters of ploidy and proliferative activity levels from cells of normal thyroid tissue, follicular adenomas, and follicular carcinomas to evaluate if these parameters could be used as an adjunct to fine needle aspiration in their diagnosis. Statistically significant higher proliferative activity levels were found in the carcinoma groups (mean S‐phase fraction [SPF] = 5.0%) compared to 2.9% for follicular adenomas and 1.3% for normal thyroid. DNA aneuploidy was identified in 73% of carcinomas and 36% of adenomas. Because of overlap of SPF values between groups, one could not rule out the presence or absence of malignancy based on DNA content parameters alone. These measurements may, however, be an aid to the decision making in patients who are poor surgical risks. © 1992 Wiley‐Liss, Inc.
Neoadjuvant chemotherapy with cytosine arabinoside by continuous infusion and cisplatin for resectable squamous cell carcinoma of the esophagus
Authors: Trudeau Marc , Batist Gerald , Thirlwell Michael , Boos Gerald , Shennib Hanni , Mulder David 
Published: February 2007

AbstractThe combination of cisplatin and cytosine arabinoside has been shown in experimental models to be synergistic. We conducted a pilot study of cytosine arabinoside and cisplatin in unresectable or metastatic cancer of the esophagus in five patients and found significant activity, also on visceral metastasis. Therefore, we decided to examine this combination in the neoadjuvant setting. Since January 1989, eight patients with squamous cell carcinoma esophageal cancer were treated with two cycles of cytosine arabinoside (50 mg/m2) by continuous infusion for 4 days and by cisplatin (100 mg/m2) on the 5th day. Their ages ranged from 54–79 years. One patient had Stage I, three had Stage II, and four had Stage HI disease. Responses assessed by endoscopy and computed tomographic (CT) scan prior to surgery were three with partial response, three with minor response, and two with no response. Only six patients were surgically resectable after chemotherapy. Toxicity consisted of grade 3 (one patient) and grade 4 (two patients) neutropenia, grade 3 (three patients) anemia, and grade 3 (two patients) and grade 4 (three patients) thrombocytopenia. All patients had subjective improvement of dysphagia 4 weeks after chemotherapy. Median survival of the whole group was 7.5 months. We concluded that there was no evidence of synergy of these drugs given in this manner in esophageal carcinoma since the response rate was no different from that achieved with cisplatin alone. © 1992 Witey‐Liss, Inc.
Soft tissue sarcomas in whites and blacks living in the United States of America
Authors: Zaki Adel , Mettlin Curtis 
Published: February 2007

AbstractFive hundred four hospitals volunteered reports on 2,355 patients in a long‐term study and 645 institutes reported on 3,457 in a short‐term study. Out of 5,623 cases of soft tissue sarcoma (STS) reported in white and blacks living in the United States of America, 574 cases (10.2%) were reported in blacks. No striking differences were found between blacks and whites concerning anatomic sites, histologic types, histologic grades, or clinical stages of STS. A higher percentage of patients with recurrences were reported in whites with liposarcoma (37.7% compared to 28.9% in blacks), and leiomyosarcoma (45% in whites compared to 39.1% in blacks). On the other hand recurrences were more frequent in fibrosarcoma and rhabdomyosarcoma in black patients. No significant differences in survival was found between white and black patients with STS. © 1992 Wiley‐Liss, Inc.
Functional results following esophagogastrectomy for carcinoma of the esophagus
Authors: Deshmane Vinay H. , Sharma Sanjay , Shinde Shashank R. , Vyas Jetendra J. 
Published: February 2007

AbstractFifty patients underwent esophagogastrectomy for histologically proven carcinoma of the esophagus from January to December 1989. The Ivor Lewis procedure was performed in 29 patients and 21 resections were performed by a left thoracoabdominal approach. There was one anastomotic leak which could not be salvaged and was responsible for the sole mortality within 30 days of surgery. The hospital stay averaged 12 days, ranging from 8–26 days. Swallowing was resumed by the 6th postoperative day for liquids and 8th day for soft solids. Following surgery, 5 patients developed dysphagia, 4 of whom responded to dilatation. The anastomosis was hand sutured in all cases except one. The suture material used had no relation to the incidence of leak or stricture formation. Eight patients complained of reflux that settled with medical management. Most patients were eating without dysphagia at the last follow‐up or death. Esophagogastrectomy can be performed with a low morbidity and mortality and provides adequate palliation of the patient's most distressing symptom, dysphagia. © 1992 Wiley‐Liss, Inc.
Inferior vena cava leiomyosarcoma
Authors: Demers Marc L. , Curley Steven A. , Romsdahl Marvin M. , Karakousis Constantine P. 
Published: February 2007

AbstractLeiomyosarcoma of the inferior vena cava is a rare malignancy, and radical resection with negative margins remains the only hope for cure. In this report we cite four cases of this tumor treated at The University of Texas M. D. Anderson Cancer Center with particular emphasis on the use of preoperative chemotherapy. In our patients, preoperative chemotherapy did not adversely affect operative outcomes or survival. The potential benefits of preoperative chemotherapy include control of micrometastases, reduction in tumor size before resection, and in situ evaluation of tumor response to chemotherapy for postoperative adjuvant therapy. © 1992 Wiley‐Liss, Inc.
Prognostic factors for noncurative gastric cancer: Univariate and multivariate analyses
Authors: Baba Hideo , Okuyama Toshiro , Hiroyuki Orita , Anai Hideaki , Korenaga Daisuke , Maehara Yoshihiko , Akazawa Kohei , Sugimachi Keizo , Lawrence Walter 
Published: February 2007

AbstractWe performed univariate and multivariate analyses of possible prognostic factors related to postoperative clinical course of patients with advanced gastric cancer. Noncurative resection was done for 119 patients with hepatic metastasis, peritoneal seeding, extensive lymph node metastasis, or direct invasion to adjacent organs, either alone or in various combinations. In the univariate analysis, 6 of 17 items such as peritoneal seeding, lymphatic invasion, vascular invasion, mode of invasion, extent of lymphadenectomy, and width of serosal invasion significantly correlated to the prognosis. The multivariate analysis indicated that three inherent pathologic factors, mode of invasion, lymph node metastasis, and hepatic metastasis, and one treatment factor, extent of lymphadenectomy, were significant variables predictive of the prognosis and that the prognosis was expected to be very poor in cases of infiltrative type, nodal involvement to tertiary nodes, presence of hepatic metastasis, and lymphadenectomy less than R3. Prognosis in terms of the extent of lymphadenectomy shows that extensive lymphadenectomy (R3) proved to be significantly effective in prolonging survival time, even after noncurative gastrectomy. We recommend extensive lymphadenectomy to prolong survival time for such patients. © 1992 Wiley‐Liss, Inc.
Prognostic assessment of superficial squamous cell carcinoma of the esophagus using karyometric analysis and nucleolar organizer regions
Authors: Maesawa Chihaya , Masuda Tomoyuki , Tamura Gen , Satodate Ryolchl , Ishida Kaoru , Saito Kazuyoshi 
Published: February 2007

AbstractTo investigate prognostic values for squamous cell carcinoma, we measured nuclear area (NA), nuclear shape factor (NSF), DNA content and mean number of nucleolar organizer regions (NOR), using formalin‐fixed, paraffin‐embedded tissue sections from 39 patients with superficial squamous cell carcinoma of the esophagus. NA and DNA content were significantly higher in patients with lymph node metastasis than in those without metastasis. NA and the NOR number were also significantly higher in patients with recurrence than in those surviving for more than 3 years without recurrence. To determine the optimal combination of these parameters for prognostic assessment, we used a stepwise discriminant analysis to obtain two linear discriminant functions. One (f = −0.331 × NA + 6.64 × NSF + 9.85) gave an accuracy of 87.2% in predicting lymph node metastasis, and the other (f = −0.071 × NA −2.34 × NOR + 13.0) yielded an overall accuracy of 88.9% in classifying patients into two groups with a better and worse prognosis. These results suggest that karyometric analysis and determination of the NOR number are useful for the prediction of disease outcome in patients with superficial squamous cell carcinoma of the esophagus. © 1992 Wiley‐Liss, Inc.
Staging invasive bladder tumors
Authors: Herr Harry W. 
Published: February 2007

AbstractStaging of bladder tumors is based primarily on the depth of tumor invasion (T‐category). Stage is important to treatment planning and prognosis. The problem is that clinical evaluation by T‐category alone often under‐stages the pathologic extent of disease and does not reliably predict treatment results. The current analysis shows that the presence of a mass palpable on bimanual examination is of prognostic value. Incorporating tumor volume with microscopic tumor invasion may enhance the usefulness of clinical staging. © 1992 Wiley‐Liss, Inc.
The effect of the fiber components cellulose and lignin on experimental colon neoplasia
Authors: Sloan David A. , Fleiszer David M. , Richards Geoffrey K. , Murray David , Brown Rea A. 
Published: February 2007

AbstractSixty Sprague‐Dawley rats were pair‐fed one of three nutritionally identical diets. One diet contained “low‐fiber” (3.8% crude fiber); the others contained “high fiber” (28.7% crude fiber) composed of either cellulose or lignin. Although both “high fiber” diets had similar stool bulking effects, only the cellulose diet was associated with a reduction in 1,2‐dimethylhydrazine (DMH)‐induced colon neoplasms. The cellulose diet was also associated with distinct changes in the gut bacterial profile and with a lowered serum cholesterol. © 1993 Wiley‐Liss, Inc.
Complete disappearance of a leiomyosarcoma of the lower extremity following preoperative hyperthermia and intra‐arterial doxorubicin
Authors: Khalek Yihad , Vilor Mabel , Sorrentino Jose , Brown Michael , Wills John , Herrera Lemuel 
Published: February 2007

AbstractLeiomyosarcoma of the extremities is an unusual tumor. Herein we report a unique and what we believe is the first case of a patient in whom there was complete disappearance of such a tumor following regional hyperthermia and chemotherapy. © 1993 Wiley‐Liss, Inc.
Breast cancer detection demonstration project data can determine whether the prognosis of breast cancer is affected by the time of surgery during the menstrual cycle
Authors: Spratt John S. , Zirnheld Jolene , Yancey John M. 
Published: February 2007

AbstractThe purpose of this study was to determine the feasibility of using Breast Cancer Detection Demonstration Project (BCDDP) data to ascertain whether the prognosis of breast cancer in premenopausal women is affected when surgery is performed relative to the different phases of the menstrual cycle. In the Louisville BCDDP only 40 cases were available for study, but even with this small number, the data indicate that survivorship was superior when the surgery was performed between days 7–20 of the menstrual cycle (P < 0.06). One thousand eighty‐seven premenopausal women underwent surgery for breast cancer during the first 5 years of the national BCDDP, beginning in 1972. This large number of cases, plus the long period of follow‐up should provide sufficient statistical power for us to evaluate if there is any relationship between the day of the menstrual cycle, the day surgery was performed, and prognosis. This feasibility study indicates that these women should be followed up and the appropriate statistical studies should be done. © 1993 Wiley‐Liss, Inc.