bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Relationship among Disconnection and Rejection Schema, Difficulties in Emotion Regulation, Mindfulness, Self-Compassion, and Undergraduate Student NSSI: A Moderated-Moderated Mediation Effect Study
Authors: Jun	Ahn Hyeong , Chang Seok-jin 
Published: March 2024

Abstract

The Disconnection and rejection schema and difficulties in emotion regulation are associated with Non-Suicidal Self-Injury (NSSI). This study examined whether trait mindfulness moderates the association between disconnection and rejection schema, difficulties in emotion regulation and NSSI. Past research has shown mindfulness and self-compassion to be positively related. However, little is known about their interrelationship and the NSSI. We hypothesized that mindfulness would attenuate NSSI, and that the level of self-compassion would modulate this effect. A convenience sample of 454 college student (40.1% male, 59.9% female) aged 19 to 29 years (M = 22.9, SD = 2.2) completed an online questionnaire that disconnection and rejection schema, NSSI, difficulties in emotion regulation, mindfulness, and self-compassion. When mindfulness and self-compassion were in harmony, NSSI decreased significantly. Self-compassion was found to reduce NSSI in participants who developed mindfulness, while it tended to worsen NSSI in participants unfamiliar with mindfulness. The results from this sample highlight the positive interconnections between mindfulness and self-compassion can be leveraged to alleviate the risk factors of NSSI in college students. To maximize the synergistic effects of these two approaches, it is recommended to prioritize mindfulness interventions.
Modifiable Arial Unit Problems for Infectious Disease Cases Described in Medicare and Medicaid Claims, 2016-2019
Authors: Williams Nick 
Published: March 2024

Abstract
Introduction: Modifiable Arial Unit Problems are a major source of spatial uncertainty, but their impact on infectious diseases and epidemic detection is unknown.
Methods: CMS claims (2016-2019) which included infectious disease codes learned through SNOMED CT were extracted and analyzed at two different units of geography; states and ‘home to work commute extent’ mega regions. Analysis was per member per month. Rolling average above the series median within geography and agent of infection was used to assess peak detection. Spatial random forest was used to assess region segmentation by agent of infection.
Results: Mega-regions produced better peak discovery for most, but not all agents of infeciton. Variable importance and Gini measures from spatial random forest show agent-location discrimination between states and regions.
Conclusions: Researchers should defend their geographic unit of report used in peer review studies on an agent-by-agent basis.
Experimental Studies of Heat Resistance and Compressive Strength of Heat-Resistant Concrete
Authors: Apshikur Baitak , Goltsev Anatoly Grigoryevich , Alimkulov Murat Mametkulovich , Rakhymberdina MarzhanYessenbekovna , Chernavin Valeriy , Aitkazin Ayazhan 
Published: March 2024

Abstract
The research purpose of the work is to extend the service life by experimental study of the performance of the liquid-layer furnace. Here, instead of large and small aggregates, the effect of the use of secondary refractory substances in reducing the cost of the concrete mixture is studied. The value of the study is to prove that heat-resistant concrete meets the technological requirements of a liquid-layer furnace, as well as experimental confirmation of the possibility of using secondary refractory materials as heat-resistant concrete aggregates. To solve this problem, it was proposed to replace the traditional method of facing the boiling floor furnaces (Fireclay brick of the SHB brand) with a monolithic concrete version. Considering that the technological feature of the boiling layer of the furnace is a high temperature up to 1000°C and an aggressive environment that causes SO3 gaseous sulfur, one of the well-known types of heat-resistant concretes, the sodium-infused liquid glass concrete type is selected as the base, and instead of cement, it is recommended to use liquid glass with low thermal conductivity, such as a material in the amorphous phase and a glass-layered composite viscous substance.
Messenger Rna Covid-19 Vaccination in Brazil: Uncertain Benefits and Risks Should Lead to Informed Choice by Health System Users, and Not to Imposition
Authors: Neves Fabricio Souza 
Published: March 2024

Abstract
Purpose. In 2024, COVID-19 vaccination became mandatory in Brazil for children aged 6 months to 4 years. In Brazil, the product available for this purpose is the Pfizer BNT162b2 Messenger RNA COVID-19 Vaccine, whose potential risks related to long-term human genomic changes are still uncertain compared to immunizations based on other platforms.
Methods. the epidemiology of Severe Acute Respiratory Syndrome was evaluated in Brazil, in the years 2022 and 2023, in children aged 6 months to 4 years, based on available public data.
Results. The number needed to treat (NNT) with BNT162b2 to prevent one death from COVID-19 in this age group can range from 208,856 to 548,246. The number needed to harm (NNH) to cause a vaccine-associated death can range from 42,373 to 909,090.
Conclusions. The results of this study indicate a borderline short-term risk/benefit ratio of BNT162b2 vaccine for the Brazilian population aged 6 months to 4 years. Given that there is no clear benefit from its mandatory use in this age group and the uncertainty regarding potential risks to human health in the long term due to possible retroposition (reverse transcription) with incorporation into the genome of parts of the genetic sequence introduced into humans as RNA exogenous by BNT162b, it is recommended that its use should not be mandatory and that vaccines based on other platforms should remain available, ensuring the right to informed choice by the health system users.
Prevalence and epidemic pattern of ecdemic multidrug-resistant tuberculosis during 2012- 2022 in Hangzhou, China
Authors: Li Qingchun , Wu Yifei , Cheng Qinglin , Lu Min , Huang Yinyan , Bai Xuexin , Jia Qingjun , Fang Zijian , Ai Liyun , Jiang Nan , Lao QiuFeng , Xie Li , Chen Junfang 
Published: March 2024

Abstract
Background
To assess the prevalence and epidemic pattern of multidrug-resistant (MDR) tuberculosis in Hangzhou City, Zhejiang Province, China during 2012–2022.
Methods
All the TB cases undergoing drug susceptibility testing (DST) during 2012–2022 were included in this study. De-identified information was extracted from the electronic database Tuberculosis Information Management System (TBIMS) for analysis of drug resistance prevalence in Hangzhou and ecdemic Multidrug-resistant TB (MDR-TB) which originated from other regions. Chi-square tests were used to compare drug resistance rates between different groups, while Chi-square tests for trend were used to evaluate the change of drug resistance rates over the years of 2012–2022. The sources and destinations of ecdemic MDR-TB were illustrated using a Sankey diagram.
Results
Of 21,127 cases included in this study, 1119 (5.3%) were MDR. A significant decline in MDR-TB rates was observed during 2012–2022. There was a significant difference in MDR-TB rates among immigrant population and local residents in Hangzhou City. Of 1119 MDR-TB cases, 515(46%) were ecdemic MDR-TB cases, of which 277(53.8%) were from other parts of Zhejiang Province and 238(46.2%) were from other provinces in China. Anhui, Jiangxi and Sichuan were among top three provinces which were the source of ecdemic MDR-TB cases. Three districts including Xiaoshan, Shangcheng and Linping districts had the most cases in Hangzhou. The proportion of ecdemic MDR-TB cases in Binjiang, Xiaoshan, Qiantang and Linping districtalso exceeded 30% of total cases.
Conclusions
MDR-TB prevalence has been declining in Hangzhou. Migrant population contributed to a significant portion of cases in Hangzhou. Interventions should be tailed to local and migrant residents.
Integrated Serum Pharmacochemistry and Network Pharmacological Analysis
Used To Explore Possible Anti-Aging Mechanisms of the Ginsenosides
Authors: Li Jing , Li Ruigang , Yang Qing , Liu Xiaoran , Qu Xiaobo , Li Na 
Published: March 2024

Background::
Although constitutive ginsenosides are credited with ginseng's remarkable
anti-aging efficacy, the mechanism of action and bioactive components of ginsenosides are
unclear.

Objective::
The goal of the study was to examine the effect of ginsenosides on D-galactose (Dgal)-
induced aging in rats and to figure out the underlying molecular mechanism using serum
pharmacochemistry and network pharmacology.

Methods::
Using behavioral, biochemical indexes, and histological analysis, ginsenosides were
evaluated for their anti-aging effects in rats induced by D-gal, and effective ingredients absorbed
in the blood were examined by ultra-performance liquid chromatography quadrupole time of flight
coupled with mass spectrometry (UPLC-Q/TOF-MS) before being subjected to network pharmacology
analysis.

Results::
As well as improving spatial learning and memory skills, Ginsenosides are known to
regulate malondialdehyde (MDA), glutathione peroxidase (GSH-Px), total antioxidant capacity
(T-AOC) and superoxide dismutase (SOD) activity. In addition, it improved the ultrastructure of
neurons in D-gal-induced rats' hippocampus. Seventy-four absorption components and metabolites
of ginsenosides were identified in aging rat serum. According to a network pharmacology study,
ginsenosides have anti-aging properties by modulating the phosphatidylinositol 3-kinase/protein
kinase B (PI3K/AKT) and mitogen-activated protein kinases (MAPK) signaling pathways.

Conclusion::
The potential mechanisms of the anti-aging effect of ginsenosides involve multiple
components, targets, and pathways. These findings serve as a foundation for further research into
the processes behind ginsenoside's anti-aging impact.
Nanotheranostics: A Cutting-Edge Technology for Cancer Management
Authors: Dash Shwetapadma , Swain Shasank Sekhar , Khuntia Auromira , Dutta Sneha , Sahoo Sanjeeb Kumar 
Published: March 2024

Abstract:
Cancer is the second-leading cause of death in the 21st century, where early detection
and appropriate therapeutic interventions are two components essential for effective cancer
management. Despite the availability of several conventional diagnostics and therapeutic agents,
cancer mortality rates are rising due to an increase in the frequency of recurrence and metastasis
in cancer patients. Therefore, tremendous efforts have been expended to address this significant
clinical issue and improve therapeutic efficacy. In this regard, nanotheranostic is a multipotential
single platform for both cancer diagnosis and treatment through enhanced aqueous solubility and
bioavailability of the encapsulated agent, stimulus responsiveness, tumor-specific targeting ability,
precise tumor imaging, and real-time drug delivery. Nonetheless, the translational success of
nanotheranostic platforms is still in its infancy and requires more extensive research in the context
of tumor heterogeneity, safety profile, and regulatory issues, which pose one of the largest
technological limitations. The present review summarizes different nanotheranostic platforms
and nanotheranostic candidates in clinical trials (AGuIX®
, NBTXR3, Ferumoxtran, MM-398,
EndoTAG-1, etc.), along with disadvantages and challenges to improving cancer diagnosis and
treatment. Overall, the concept, platform, and technical knowledge of nanotheranostics are really
helpful to academic and pharmaceutical researchers.
ZNF695, A Potential Prognostic Biomarker, Correlates with Im mune
Infiltrates in Cervical Squamous Cell Carcinoma and Endoce rvical
Adenocarcinoma: Bioinformatic Analysis and Experimental Verification
Authors: Ding Xiaojuan , Wan Ailing , Qi Xin , Jiang Ke'er , Liu Zhao , Chen Buze 
Published: March 2024

Background::
The role of Zinc Finger Protein 695 (ZNF695) is unclear in cervical squamous
cell carcinoma and endocervical adenocarcinoma (CESC).

Objective::
The objective of this study was to conduct a comprehensive analysis and experimental
validation of ZNF695 in CESC.

Methods::
The study investigated the expression of ZNF695 in both pan-cancer and CESC, utilizing
data from The Cancer Genome Atlas (TCGA) database to assess its diagnostic value. The present
study investigated the association between ZNF695 expression levels and clinical characteristics,
as well as prognosis, in patients with CESC. The study explored potential regulatory networks
involving ZNF695, including its association with immune infiltration, immune score, stemness
index based on mRNA expression (mRNAsi), and drug sensitivity in CESC. We explored the
expression of ZNF695 in CESC single cells. ZNF695 expression was validated using GSE29570.

Results::
ZNF695 was found to be aberrantly expressed in pan-cancer and CESC. There was a significant
correlation observed between an elevated level of ZNF695 expression in patients with
CESC and histological grade (p = 0.017). Furthermore, a strong association was found between
high ZNF695 expression in CESC patients and poorer overall survival (OS) (HR: 1.87; 95% CI:
1.17-3.00; p = 0.009), Progression-free Survival (PFS) (HR: 1.86; 95% CI: 1.16-2.98; p = 0.010),
and Disease-specific Survival (DSS) (HR: 1.98; 95% CI: 1.15-3.42; p = 0.014). The expression of
ZNF695 in CESC patients (p = 0.006) was identified as an independent prognostic determinant.
ZNF695 was associated with steroid hormone biosynthesis, oxidative phosphorylation, and so on.
ZNF695 expression correlated with immune infiltration, immune score, and mRNAsi in CESC.
ZNF695 expression significantly and negatively correlated with AICA ribonucleotide, BIX02189,
QL-XI-92, STF-62247, and SNX-2112 in CESC. ZNF695 gene was upregulated in CESC tissues
and cell lines. ZNF695 was significantly upregulated in the CESC cell lines.

Conclusion::
ZNF695 may be a potential prognostic biomarker and immunotherapeutic target for
CESC patients.
Predictors of Emboli in Mechanical Thrombectomy for Anterior
Circulation Stroke
Authors: Kwon Yongho , Yi Ho Jun , Shin Dong-Seong , Kim Bum-Tae 
Published: March 2024

Objective:
Emboli commonly occurs in mechanical thrombectomy (MT). The objective
of this study was to analyze predicting factors of emboli after MT.

Methods:
Patients who underwent MT with successful reperfusion for anterior circulation occlusion
were enrolled. Emboli included distal emboli at digital subtraction angiography (DSA) and
unexpected embolic infarct on diffusion-weighted image (DWI) without distal emboli at DSA.
Baseline characteristics, procedural details, angiographic outcomes, and clinical outcomes were
reviewed. Multivariable analyses were performed to evaluate predictive factors for the occurrence
of emboli.

Results:
Of 601 patients, 149 (24.8%) patients had distal emboli at DSA, and 169 (28.1%) patients
had unexpected embolic infarction on DWI even without distal emboli at DSA. A total of
318 (52.9%) patients were enrolled in the embolic group, and 283 (47.1%) patients were assigned
to the non-embolic group. In multivariate analysis, larger microcatheter (OR 1.26, 95%
CI 1.12–1.94; p = 0.047), clot passage (OR 1.33, 95% CI 1.07–1.87; p = 0.041), use of balloon
guide catheter (BGC) (OR 0.70, 95% CI 0.52–0.92; p = 0.014), early ballooning of BGC (OR
0.68, 95% CI 0.50–0.90; p = 0.009), and longer stent retriever (OR 0.72, 95% CI 0.54–0.90; p =
0.029) were associated with occurrence of emboli.

Conclusion:
MT with only a stent retriever, use of a larger microcatheter, and clot passage
might increase the risk of emboli. In contrast, contact aspiration thrombectomy, use of BGC,
early ballooning of BGC, and use of longer stent retrievers could reduce the chance of emboli.
Ginsenoside Rg3: A Review of its Anticancer Mechanisms and Potential
Therapeutic Applications
Authors: Wu Lei , Bai Lin , Dai Wenshu , Wu Yaping , Xi Pengjun , Zhang Jie , Zheng Lily 
Published: March 2024

Background:
Traditional Chinese Medicine (TCM) has a long history of treating various
diseases and is increasingly being recognized as a complementary therapy for cancer. A
promising natural compound extracted from the Chinese herb ginseng is ginsenoside Rg3, which
has demonstrated significant anticancer effects. It has been tested in a variety of cancers and tumors
and has proven to be effective in suppressing cancer.

Objective:
This work covers various aspects of the role of ginsenoside Rg3 in cancer treatment,
including its biological functions, key pathways, epigenetics, and potential for combination therapies,
all of which have been extensively researched and elucidated. The study aims to provide a
reference for future research on ginsenoside Rg3 as an anticancer agent and a support for the potential
application of ginsenoside Rg3 in cancer treatment.
Federated Learning-based Black Hole Prevention in the Internet of Things
Environment
Authors: Karunakaran Martin Victor , Jebadurai Immanuel Johnraja , Paulraj Getzi Jeba Leelipushpam 
Published: March 2024

Background and Objective::
The Internet of Things offers ubiquitous automation of
things and makes human life easier. Sensors are deployed in the connected environment that sense
the medium and actuate the control system without human intervention. However, the tiny connected
devices are prone to severe security attacks. As the Internet of Things has become evident in
everyday life, it is very important that we secure the system for efficient functioning.

Method::
This paper proposes a secure federated learning-based protocol for mitigating BH attacks
in the network.

Results::
The experimental result proves that the intelligent network detects BH attacks and segregates
the nodes to improve the efficiency of the network. The proposed techniques show improved
accuracy in the presence of malicious nodes.

Conclusion::
The performance is also evaluated by varying the attack frequency time.
Risk Assessment Model of Emergency Lane Change Behavior for
Intelligent Vehicles
Authors: Yixuan Feng , Huanhuan Zhang , Minjie Yao , Hongchao Wu 
Published: March 2024

Background::
The condition that vehicles are prone to skidding during emergency lane
changing, an anti-rollover constraint is added to the trajectory planning.

Methods::
The evaluation index is constructed by the lateral load transfer rate LTR, so as to put
forward a seventh-order polynomial trajectory planning method considering the anti-rollover. It
improves the safety and stability of the planned trajectory of the intelligent vehicle when changing
lanes in an emergency. The risk assessment index under different emergency lane changing modes
is obtained through simulation tests, the phase plane method is used to classify the risk level and
formulate a reasonable risk decision-making mechanism. A patented model for risk assessment
considering the risk of instability is designed.

Results::
The tests conducted on a low-friction road show that when the risk assessment factor is in
the range of the steering lane change mode intervals, the steering controller maneuvers the vehicle
to make an emergency lane change with a seventh-order polynomial trajectory.

Conclusion::
The small fluctuation of the LTR verifies the feasibility of the model.
Penilian Risiko Paparan Debu Silika Terhadap Pekerja di Industri Pengolahan Bijih Mineral
Authors: Putro Edi Karyono , Kusnadi Saskia Nur Fadhilah , Susanto Arif , Zannah Miftahul , Mahalisa Rizky , Manuel Anthony Andorful 
Published: March 2024

Latar Belakang: Proses industri bijih mineral menghasilkan debu silika yang berbahaya bagi kesehatan pekerja. Komposisi debu seperti silika bersifat karsinogenik dan dapat melebihi Nilai Ambang Batas (NAB).Tujuan: Penelitian ini bertujuan untuk menganalisis risiko paparan debu silika terhadap tiga jenis sistem rotasi kerja di industri pengolahan bijih mineral.Metode: Metode yang digunakan adalah metodologi kuantitatif Analisis Risiko Kesehatan Lingkungan (ARKL) dengan menghitung nilai Excess Cancer Risk (ECR) sesuai dengan kondisi jalur paparan, agen risiko, serta sistem rotasi kerja. Analisis dilakukan pada paparan debu silika tahun 2020 dan 2021. Metode pengambilan sampel debu silika menggunakan pengukuran yang ditetapkan oleh OSHA-ID142.Hasil: Konsentrasi debu silika pada proses industri bijih mineral melebihi NAB . Tahun 2020 paparan debu silika berkisar antara 0.41-2.99 μg/m3, tetapi mengalami penurunan pada 2021 menjadi 0.05-1.16 μg/m3. Baik pada tahun 2020 maupun 2021, perhitungan ECR berada dalam rentang aman yang ditetapkan oleh United States of Environmental Protection Agency (US EPA). Hasil perhitungan ECR yaitu di bawah 10-4 untuk ketiga sistem rotasi kerja di semua lokasi pengukuran.Kesimpulan: Konsentrasi debu silika diatas NAB tetapi evaluasi ARKL menunjukkan terdapat risiko karsinogenik terhadap tiga jenis rotasi kerja berada di bawah batas aman, sehingga tidak membahayakan pekerja. Industri bijih mineral perlu terus meningkatkan pengendalian debu untuk mengurangi konsentrasi debu silika dibawah NAB.
Analisis Tantangan Kesiapan Implementasi Rekam Medis Elektronik di Puskesmas Kota Padang
Authors: Siswati Sri , Ernawati Tuty , Khairunnisa Muthia 
Published: March 2024

Latar Belakang: Puskesmas merupakan salah satu fasilitas kesehatan yang wajib melaksanakan Rekam Medis Elektronik (RME) paling lambat 31 Desember 2023 melalui Permenkes Nomor 24 Tahun 2022 tentang Rekam Medis. Namun, faktor kesiapan SDM menjadi tantangan dalam pengimplementasiannya, seperti kurangnya pengetahuan dan skill komputer.Tujuan: Penelitian ini bertujuan untuk mengetahui faktor dan hambatan yang mempengaruhi kesiapan tenaga kesehatan dalam menerapkan RME di Puskesmas.Metode: Penelitian mixed-method dengan model sequantial explanatory dilakukan pada Mei sampai Oktober 2023 di 23 Puskesmas Kota Padang. Tahap penelitian kuantitatif dilakukan secara cross-sectional terhadap 69 sampel, yaitu dokter, perekam medis, dan perawat. Penelitian kualitatif dilakukan terhadap 46 informan, yaitu 23 kepala puskesmas dan 23 perekam medis dengan cara purposive sampling.Hasil: Dari 69 responden, hanya 33 (47,8%) dengan 39,4% diantaranya adalah perekam medis yang siap menggunakan RME. Tingkat pendidikan, pengalaman kerja, pengetahuan, dan persepsi mempengaruhi signifikan terhadap kesiapan tenaga kesehatan melaksanakan RME. Penyebab belum siapnya tenaga kesehatan dalam melaksanakan RME adalah pelatihan RME tidak diberikan ke seluruh tenaga dan kurangnya keterampilan komputer dan pengetahuan tentang RME.Kesimpulan: Tidak semua tenaga kesehatan siap menerapkan RME karena pelatihan hanya didapat oleh perekam medis sehingga perlu pelatihan untuk meningkatkan pengetahuan RME dan meningkatkan keterampilan komputer bagi seluruh petugas yang menggunakan RME dalam pelayanannya.