bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immediate Skin Test Reactions to Spices
Authors: Niinimäki A. , Hannuksela M. 
Published: May 2007

Scratch tests with common spices were performed in 1,120 atopic and 380 non‐atopic patients. Positive skin test reactions were seen almost exclusively in atopics. Curry and paprika produced positive reactions most frequently, and when the components of curry were tested separately, coriander, caraway, cayenne and mustard were responsible for the vast majority of the skin reactions.A high correlation between positive skin test reactions to spices, especially to curry and its components, and tree pollens, fruits and vegetables was demonstrated, suggesting that there may be a group of cross allergies.Clinical symptoms from ingested spices were noticed by five patients. When small amounts of spices were spread on the oral mucosa, local reactions, especially in the mouth and nasopharynx, were found in 14 out of 35 unselected patients with positive skin test reactions. Peroral challenges with spices in gelatine capsules were negative in 20 non‐selected patients.
Terbutaline Depot Tablets in Asthma
Authors: Taudorf Ebbe , Bundgaard Allan , Fagerstrom Per Olof , Weeke Eva , Weeke Bent 
Published: May 2007

A sustained release preparation of terbutaline sulphate has been formulated (Bricanyl® depot tablets) in order to extend the duration and accordingly change the dosage regimen to twice a day. This presentation gives a summary of a clinical trial performed in order to study effect and side effects of terbutaline depot tablets 7.5 mg twice a day compared to terbutaline tablets 5 mg three times a day.Patients suffering from perennial asthma and with daily requirement of asthma medicine were accepted for the study. The trial was a double‐blind cross‐over, double dummy and randomized. The tablets were given in two consecutive periods of 7 day's duration each. The effect of terbutaline depot tablets was equal to the effect of the ordinary terbutaline tablets. The indication for using depot tablets in the basic treatment of bronchial asthma is a better patient compliance due to medication twice a day. Furthermore in patients with unstable bronchial asthma and in patients with morning dips in PEF the more stable plasma concentration may perhaps keep the patients in a more steady state.
Serum Concentrations of Theophylline in Children Treated with Two Daily Doses of a Sustained‐Release Theophylline Preparation
Authors: Sommer B. , Pedersen S. E. , Nathan E. 
Published: May 2007

Over a 3‐month period 22 asthmatic children were treated with a sustained‐release theophylline preparation (Nuelin Retard®, Riker) in twice‐daily doses. During the first 2 weeks of treatment slight side‐effects were observed in 14 children. Over the remaining 10‐week period only four children experienced minor side‐effects.Serum theophylline levels 4 hours after tablet administration were measured three times and serum levels just before tablet administration were measured once during the observation period. The average difference between the serum levels of theophylline just before tablet administration and the corresponding serum value 4 hours afterwards was 4.2 μg/ml. The serum values 4 hours after tablet administration showed an insignificant fall throughout the period and patient compliance was assessed as good.When the average requirements of theophylline in mg/kg found by Wyatt et al. (15) (Table 2) were used as initial doses, few dosage adjustments were necessary and no serum values were greater than 26.2 μg/ml, but in order to avoid serum levels above 20 μg/ml initial doses should be decreased about 10% and final adjustment made with the aid of serum theophylline measurement under steady state conditions.In children, Nuelin Retard given in two daily doses is capable of maintaining a constant therapeutic serum concentration for the whole 24‐hour period.
IgE Concentrations Measured by PRIST® in Serum of Healthy Adults and in Patients with Respiratory Allergy
Authors: Zetterstöm Olle , Johansson S. G. O. 
Published: May 2007

In order to establish reference values for total serum IgE in an adult non‐atopic population, 175 individuals. 17–85 years of age. were investigated. The usefulness of a sensitive method (PRIST®) for serum JgK determinations in discriminating atopy from mm‐atopic conditions in a Her go logical routine diagnosis was elucidated by investigating 445 patients with symptoms of asthma, rhinitis, urticaria and eczema. Comparisons were made with case histories. in viva tests and circulating IgE antibodies.The geometric mean for serum IgE in the reference material was 13.2 kU/1 with a 2 SD range of 1.53 to 114 kU/1. No significant difference between age groups or sexes was observed. In patients classified as non‐atopic and pronounced atopic, the geometric mean values for IgE were 40, 123 and 458 kU/1 respectively. The IgE level correlated with number of allergens positive in RAST and with skin test results.It is concluded that IgE determinations are of great help in discriminating atopic conditions from other diseases with similar symptoms. A serum IgE value above 100 kU/1 in a patient is strong evidence for the presence of an atopic disease while a value below 20 kU/l indicates that the symptoms are due to intrinsic or infectious disease.
Influence of Dialysable Transfer Factor on IgE Concentrations in Patients with Atopic Dermatitis
Authors: Jarisch Reinhart , Eibl Martha , Sandor Istvan , Boltz Angelika 
Published: May 2007

Dialysable transfer factor (TF) was given in 10 paediatric patients with severe atopic dermatitis (AD). Ten patients with AD, matched for age and severity of disease, served as controls.Prior to the therapy with TF and at weekly intervals thereafter, T‐ and B‐cells in the blood, PHA‐stimulation, total IgE and specific IgE antibodies to inhalant and food antigens were determined. Therapy with TF was followed by IgE depression in 8/10 patients and was most pronounced in three patients with initially high levels. Some decrease of IgE levels was seen in four controls also, none of them, however, fell to normal levels as was seen in two of the treated patients.Specific IgE levels decreased slightly, but always remained within the pathological range. T‐cell counts in the blood increased in 2/10 cases as well as PHA‐stimulation. B‐cell counts remained within normal limits. Clinical improvement was seen in one patient, five improved slightly and four remained unchanged.Our results indicate, that transfer factor can lower total IgE levels in cases with atopic dermatis. The effect is most marked in patients with high total IgE levels. Skin involvement, however, does not closely follow in vitro findings.
In vitro Characterization of Synthesized Thyroglobulin Immune Complexes (IC)
Authors: Feldt‐Rasmussen Ulla , Husby Steffen , Blärbjerg Ole , Date John , Nielsen Henrik 
Published: May 2007

Human thyroglobulin (Tg) immune complexes (TgIC) were preformed at different ratios from purified Tg, and Tg antibodies (TgAb) obtained from six patients with autoimmune thyroid diseases. TgIC were characterized by precipitation with polyethylene glycol, and sedimentation in sucrose gradient. TgIC from one patient were further characterized by concanavalin A (con A), and binding to the complement factor Clq and rheumatoid factor (RF).Tg and TgIC had almost identical binding to con A, no binding to Clq, but could be partially separated by ultracentrifugation and polyethylene glycol. The highest degree of separation was obtained by a RF‐coated plastic tube radiometric assay, using 125‐I‐rabbit TgAb as indicator. Tg showed no binding to RF, and a dose‐response curve of TgIC in serum could be established. There was a dependence of the Tg‐TgAb ratio, TgIC at equilibrium and in antibody excess being detected most efficiently.The method may serve as an aid in the evaluation of the fate of Tg, TgAb and TgIC following thyroid damage (surgery, radioiodine) and may be extended as a model system in the investigation of immune complexes in connection with autoimmune disorders.
Inhibitory Effect of KWD 2131, Terbutaline, and DSCG on the Immediate and Late Allergen‐Induced Bronchoconstriction
Authors: Hegardt B. , Pauwels R. , Van Der Straeten M. 
Published: May 2007

β‐adrenoceptor stimulants exhibit both bronchodilating and anti‐allergic activities. KWD 2131 is a new β‐agonist with preferably anti allergic property.In an earlier study, nebulized KWD 2131 in a non‐bronchodilating dose (0.25 ‐ 0.50 mg) did not give significant protection against immediate reaction.The present study evaluated whether an increased nebulized dose of the new compound (5 mg) could protect against either immediate and/or late responses. The response was compared with a nebulized dose of terbutaline (5 mg) and with twice the recommended dose DSCG (40 mg). The study included 10 patients with known allergic asthma. It was designed as a single‐blind cross‐over trial with randomized allocation of the drugs. Lung functions were measured spirometrically and by body‐plethysmograph; flow volume curves were drawn.KWD 2131 gave no significant protection against immediate reaction. Both terbutaline and DSCG did so, terbutaline being more efficient. Contrary to the β‐agonists, DSCG also gave protection against late response.
RAST in the Diagnosis of Dog Dander Allergy
Authors: Vanto T. , Viander M. , Koivikko A. , Schwartz B. , Løwenstein H. 
Published: May 2007

The results of the skin, bronchial or conjunctival provocation tests and of the radioallergosorbent test (RAST) with dog dander and hair extract preparations from two different producers were compared, 202 asthmatic children were included in the study. The clinical tests, Al‐RAST and paper RAST. were performed using only one allergen preparation (Hu 073), while two allergen preparations (e2 and e5) were used in Phadebas® RAST.A good correlation was generally found between the results of the clinical diagnostic tests, the clinical history and the results of RAST.Phadebas RAST e2 was the most specific but the least sensitive: it gave a class 0 result in 18% and class 3–4 in 34.5% of the subjects with a positive provocation test. The corresponding numbers for e5 RAST were 6.0% and 70.2%, respectively. Al‐RAST was equally sensitive, but had lower specificity than Phadebas RAST e5. The correlation between Phadebas RAST e5 and paper RAST Hu 073 was excellent, which indicates a remarkable similarity between these allergen extracts.Using sensitive, immunochemically standardized Phadebas RAST e5 or Al‐RAST methods, classes 0–1 can be regarded as negative, class 2 as doubtful and classes 3–4 as clinically positive results.
Effects of Oral Theophylline Combined with Oral and Inhaled β2‐Adrenostimulants in Asthmatics
Authors: Svedmyr K. 
Published: May 2007

The acute ventilatory, cardiovascular and tremorogenic effect of a high oral dose of terbutaline (5 mg) was compared with that of half the dose (2.5 mg) combined with 280 mg anhydrous theophylline orally in a randomized, double‐blind, cross‐over study in eight asthmatics. After 120 min. when steady‐state bronchodilation was achieved, five terbutaline inhalations (1.25 mg terbutaline sulphate) were added to both treatment regimens. The mean maximum plasma concentration of theophylline was then 7 μg/ml (39 μmol/l).Inhalation of a β2‐adrenostimulant had a very good additional effect without increasing side effects in these patients with good inhalation technique. The oral low‐dose combination gave significantly better bronchodilation than the high dose of terbutaline alone and caused significantly less tremor. Although the combination only had an additive bronchodilating effect, it may offer important clinical advantages. If the patient cannot use the metered dose aerosol, an oral low dose combination should be preferred to a single high dose of either theophylline or β2‐adrenostimulants.In patients with good inhalation technique but not controlled by inhalations from a metered dose aerosol alone, a combination of oral theophylline and terbutaline in “suboptimal” dose and an inhaled β2‐agonist in individually titrated optimal dose gave a maximal bronchodilating effect with minimum side effects.
Thyroid Stimulating Antibodies, Thyroglobulin Antibodies and Serum Proteins during Treatment of Graves’ Disease with Radioiodine or Propylthouracil
Authors: Feldt‐Rasmussen Ulla , Bech Karine , Date John , Pedersen Per Hyltoft , Johansen Klaus , Madsen Stig Nistrup 
Published: May 2007

The relation between serum concentrations of thyroglobulin antibodies (TgAb). thyroid‐stimulating antibodies (TSAb) and serum immunoglobulins during treatment of Graves' disease was studied in 36 consecutive patients treated randomly with 131‐iodine (n= 16) or propylthiouracil (n= 20). The patients were investigated before treatment was started anti on seven occasions within the following year.In the entire patient group 78% were positive for TSAb and 47 % for TgAb, There was a significant correlation between TSAb and TgAb in 15 patients concomitantly positive. There were no significant changes in serum immunoglobulins during treatment in either group of patients.In the radioiodine‐treated group of patients TgAb was reduced after 1 week, whereas TSAb showed insignificant variations. After 5–10 weeks both antibodies increased, for TgAb with a median peak level 3 times above the initial concentration. Of 16 patients treated with radioiodine live developed myxoedema and four of these were positive for TgAb. There was a relation between the development of myxoedema and the ratio between increases of TSAb and TgAb. Increase in TSAb was not related to serum thyroglobulin (Tg) measured in TgAb‐negative patients.Propytthiouracil showed minor effect on the studied variables, but with lower mean values of Tg, TgAb and TSAb at the end of the observation period.The results indicate an immunological relation between TSAb and TgAb, although differences between their courses exist in some situations.
Anti‐IgG Antibodies during Immunotherapy with Purified Grass Pollen Extracts
Authors: ØSterballe O. , Egeskjold Else‐Marie , Johansen A. S. , Skov P. 
Published: May 2007

In a double blind study 40 patients were allocated specific immunotherapy (hyposensitization) with partially partially purified timothy extract or two timothy major allergens 19, 25. All patients had typical grass pollen hay level, in 27% associated with grass pollen asthma and in 13% with birch pollen allergy.Serum IgG anti‐IgG antibodies were determined after dithiothreitol treatment. Before hyposensitization, IgG anti‐IgG times ≥9 were demonstrated in 45% of the patients During hyposensitization IgG anti‐IgG titres showed a slight initial increase followed by a decrease below pretreatment level. Neither increase nor decrease was statistically significant. Reactions to rabbit IgG F(ab)2 fractions were only obtained during hyposensitization.The occurrence of anti‐IgG antibodies did not correlate with symptoms, side effects, or the level of allergen‐specific IgG. In a previous study it was demonstrated that patients with multiallergy hyposensitized with combined allergen extracts showed a statistrated significant increase in IgG anti‐IgG titres during treatment. This increase failed to appear in the resent patients allergic only to pollen and treated with purified allergen extracts. It is therefore suggested that a multiallergic condition and the combination and/or purification of allergen extracts administered during hyposensitization may influence the production of IgG anti‐IgG antibodies.