bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevention of colitis‐associated carcinogenesis in a mouse model by diet supplementation with ursodeoxycholic acid
Authors: Loddenkemper Christoph , Keller Sylvia , Hanski Marie‐Loise , Cao Minh , Jahreis Gerhard , Stein Harald , Zeitz Martin , Hanski Christoph 
Published: December 2005

AbstractBile acids in the intestinal lumen contribute to the homeostatic regulation of proliferation and death of the colonic epithelial cells: Deoxycholic acid (DCA) appears to enhance and ursodeoxycholic acid (UDCA) to attenuate the process of chemically induced carcinogenesis. We studied the effects of UDCA on colitis‐related colorectal carcinogenesis. Three groups of 25 mice were given 0.7% dextran sulphate in drinking water for 7 days and pure water for 10 days and were fed a standard diet containing double iron concentration. In 2 groups, the diet was supplemented with 0.2% cholic acid (CA), the precursor of DCA, or with 0.4% UDCA. After 15 cycles, the histology, the expression of MUC2, β‐catenin, p27 and p16 and the fecal water concentration of DCA and UDCA were investigated. All animals showed colitis with similar severity and histologic as well as immunophenotypic alterations, resembling those of human colitis. Among the animals fed the nonsupplemented diet, 46% developed colorectal adenocarcinomas and 54% anal‐rectal squamous cell carcinomas. The prevalence of dysplasia and carcinomas did not change significantly in the animals given CA. Among the mice fed with UDCA, none developed adenocarcinomas and 20% squamous carcinomas. Dysplastic lesions were found in 88%, 67% and 40% of each group, respectively. The prevalence of dysplasia as well as of carcinoma showed an inverse relationship to the UDCA concentration in the fecal water. These data indicate that UDCA suppresses colitis‐associated carcinogenesis. This model is suitable for investigation of the mechanism of the anticarcinogenic effect of UDCA in vivo. © 2005 Wiley‐Liss, Inc.
Anthropometric measures, endogenous sex steroids and breast cancer risk in postmenopausal women: A study within the EPIC cohort
Authors: Rinaldi Sabina , Key Tim J , Peeters Petra H.M. , Lahmann Petra H. , Lukanova Annekatrin , Dossus Laure , Biessy Carine , Vineis Paolo , Sacerdote Carlotta , Berrino Franco , Panico Salvatore , Tumino Rosario , Palli Domenico , Nagel Gabriele , Linseisen Jakob , Boeing Heiner , Roddam Andrew , Bingham Sheila , Khaw Kay‐Tee , Chloptios John , Trichopoulou Antonia , Trichopoulos Dimitrios , Tehard Bertrand , Clavel‐Chapelon Francoise , Gonzalez Carlos A. , Larrañaga Nerea , Barricarte Aurelio , Quirós J. Ramón , Chirlaque Maria‐Dolores , Martinez Carmen , Monninkhof Evelyne , Grobbee Diederick E. , Bueno‐de‐Mesquita H. Bas , Ferrari Pietro , Slimani Nadia , Riboli Elio , Kaaks Rudolf 
Published: December 2005

AbstractIn a large case–control study on breast cancer risk and serum hormone concentrations, nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, we examined to what extent the relationship of excess body weight with breast cancer risk may be explained by changes in sex steroids. Height, weight, waist and hip circumferences, and serum measurements of testosterone [T], androstenedione [Δ4], dehydroepiandrosterone sulphate [DHEAS], estradiol [E2], estrone [E1] and sex‐hormone binding globulin [SHBG] were available for 613 breast cancer cases, and 1,139 matched controls, who were all menopausal at the time of blood donation. Free T [fT] and free E2 [fE2] were calculated using mass action equations. Breast cancer risk was related to body mass index (BMI) (RR = 1.11 [0.99–1.25], per 5 kg/m2 increase in BMI), and waist (RR = 1.12 [1.02–1.24], per 10 cm increase) and hip circumferences (RR = 1.14 [1.02–1.27], per 10 cm increase). The increase in breast cancer risk associated with adiposity was substantially reduced after adjustment for any estrogens, especially for fE2 (from 1.11 [0.99–1.25] to 0.99 [0.87–1.12], from 1.12 [1.02–1.24] to 1.02 [0.92–1.14] and from 1.14 [1.02–1.27] to 1.05 [0.93–1.18] for BMI, waist and hip circumferences, respectively). A modest attenuation in excess risk was observed after adjustment for fT, but the remaining androgens had little effect on the association of body adiposity with breast cancer. Our data indicate that the relationship of adiposity with breast cancer in postmenopausal women could be partially explained by the increases in endogenous estrogens, and by a decrease in levels of SHBG. © 2005 Wiley‐Liss, Inc.
Meat, fish, poultry and egg consumption in relation to risk of pancreatic cancer: A prospective study
Authors: Larsson Susanna C. , Håkanson Niclas , Permert Johan , Wolk Alicja 
Published: December 2005

AbstractHigh meat consumption has been associated with increased risk of pancreatic cancer in several, although not all, case‐control studies. However, prospective data on this relationship are sparse, and the results have been inconsistent. We prospectively evaluated meat, fish, poultry, and egg consumption in relation to pancreatic cancer incidence in a population‐based cohort of 61,433 Swedish women. Diet was assessed with a food‐frequency questionnaire at baseline (1987–1990) and again in 1997. Pancreatic cancers were ascertained through linkage to the Swedish Cancer Register. Cox proportional hazards models were used to estimate multivariate hazard ratios with 95% confidence intervals (CI). During the 941,218 person‐years of follow‐up, from 1987 through 2004, 172 incident cases of pancreatic cancer were diagnosed. Long‐term red meat consumption (using data from both dietary questionnaires) was positively associated with risk of pancreatic cancer (p‐trend = 0.01), whereas long‐term poultry consumption was inversely (p‐trend = 0.04) associated with risk. The multivariate hazard ratios for the highest versus the lowest category of consumption were 1.73 (95% CI = 0.99–2.98) for red meat and 0.44 (95% CI = 0.20–0.97) for poultry. There were no significant associations with processed meat, fish or egg consumption. Findings from this prospective study suggest that substituting poultry for red meat might reduce the risk of pancreatic cancer. © 2005 Wiley‐Liss, Inc.
TAK1‐mediated stress signaling pathways are essential for TNF‐α‐promoted pulmonary metastasis of murine colon cancer cells
Authors: Choo Min‐Kyung , Sakurai Hiroaki , Koizumi Keiichi , Saiki Ikuo 
Published: December 2005

AbstractWe have recently established a TNF‐α‐promoted metastasis model, in which the ability to metastasize to the lung was enhanced by stimulation of cultured colon 26 cells with TNF‐α before intravenous inoculation. To investigate intracellular events in metastatic cascades of TNF‐α‐treated cancer cells, we have focused on the stress signaling pathways to c‐Jun N‐terminal kinase (JNK) and p38. Treatment with a specific inhibitor, SP600125 or SB203580, in vitro suppressed TNF‐α‐induced migration and pulmonary metastasis. Activation of endogenous TAK1, a mitogen‐activated protein kinase (MAP3K) regulating the JNK and p38 MAPK pathways, was induced rapidly by TNF‐α, and co‐transfection of TAK1 with its activator protein TAB1 stimulated activation of JNK and p38 MAPKs, which led to activation of the transcription factor AP‐1. The activation of stress signaling pathways by TAK1 resulted in enhanced migration to fibronectin in vitro and metastasis to the lung in vivo without affecting cell proliferation in vitro and tumor growth in vivo. Moreover, knockdown of endogenous TAK1 using small interfering RNA (siRNA) suppressed the TNF‐α‐induced JNK/p38 activation, migration and pulmonary metastasis. These results indicate that TAK1‐mediated stress signaling pathways in cancer cells are essential for TNF‐α‐promoted metastasis to the lung. © 2005 Wiley‐Liss, Inc.
Food groups and risk of non‐Hodgkin lymphoma: A multicenter, case‐control study in Italy
Authors: Talamini Renato , Polesel Jerry , Montella Maurizio , Dal Maso Luigino , Crovatto Marina , Crispo Anna , Spina Michele , Canzonieri Vincenzo , La Vecchia Carlo , Franceschi Silvia 
Published: December 2005

AbstractIncidence of non‐Hodgkin lymphoma (NHL) has been rising worldwide, but the reasons are undefined. Dietary habits may play a role in the etiology of NHL by influencing the metabolic pathways of several cells of the immune system. This case‐control study investigated the relation between food consumption and NHL risk. Between 1999 and 2002, we conducted a hospital‐based case‐control study on NHL in 2 areas of Italy. Cases were 190 patients (median age 58 years) with incident NHL admitted to specialized and general hospitals. Controls were 484 patients (median age 63 years) with acute non‐neoplastic conditions admitted to the same hospitals network of cases. A validated food‐frequency questionnaire was used to assess habitual diet 2 years before interview. Unconditional multiple logistic regression was used to estimate the odds ratios (OR) and the corresponding 95% confidence intervals (CI), with allowance for energy intake, according to the residual model. Consumption of highest versus lowest quartile of pasta/rice (OR = 1.87, 95% CI: 1.04–3.36) and cheese (OR = 1.66, 95% CI: 0.98–2.83) were associated with a significantly increased NHL risk. Inverse association was found for vegetables (OR = 0.49, 95% CI: 0.28–0.87), fruits (OR = 0.51, 95% CI: 0.30–0.85), and egg consumption (OR = 0.59, 95% CI: 0.36–0.97). The association of pasta/rice was also supported by an increased risk of high glycemic load levels (OR = 1.86, 95% CI: 1.04–3.32). In conclusion, our results suggested that diet could affect NHL risk. © 2005 Wiley‐Liss, Inc.
Resolvable modified group divisible designs with block size three
Authors: Wang Chengmin , Tang Yu , Danziger Peter 
Published: December 2005

AbstractA resolvable modified group divisible design (RMGDD) is an MGDD whose blocks can be partitioned into parallel classes. In this article, we investigate the existence of RMGDDs with block size three and show that the necessary conditions are also sufficient with two exceptions. © 2005 Wiley Periodicals, Inc. J Combin Designs 15: 2–14, 2007
Converging on a richer understanding of human behavior and experience through a blending of cognitive and clinical psychology
Authors: Roskos‐Ewoldsen Beverly 
Published: December 2005

AbstractMcClelland, Kemps, and Tiggemann's (this issue) use of experimental methods typically used in cognitive psychology to reduce the intensity of food cravings formed the basis for maintaining that an understanding of human experiences and behaviors requires a blending of cognitive and clinical psychological approaches. Clinical psychology can adapt cognitive models of information processing to understand the mechanisms underlying clinical phenomena and to create and evaluate effective interventions. Cognitive psychology should broaden its scope to include information relevant to clinical phenomena, such as desire, attitudes, self‐regulation, and temperament. Only through a blending of these two fields will we converge on a richer understanding of human behavior and experience. © 2005 Wiley Periodicals, Inc. J Clin Psychol 62: 367–371, 2006.
Developing an evidence base in clinical psychology
Authors: Davidson Karina W. , Spring Bonnie 
Published: December 2005

AbstractWe suggest a process for clinical psychologists to collect an evidence base and join the evidence‐based movement already underway in many areas of medicine. To illustrate this process, we review the history of cholesterol discovery, evaluation, and management as an evidence‐based process, extracting lessons applicable to the field of psychology. By examining these lessons and building consensus, clinical psychologists can advance the movement along an evidence‐based practice continuum, improve client care, build a more informative evidence base, and promote equitable reimbursement for psychological practice. © 2005 Wiley Periodicals, Inc. J Clin Psychol 62: 259–271, 2006.
The influence of outcome measures in assessing client change and treatment decisions
Authors: Hatfield Derek R. , Ogles Benjamin M. 
Published: December 2005

AbstractThis study investigated the influence that information in the form of outcome measures and client verbal reports can have on treatment decisions and clinician judgment of client change. A random national sample of psychologists (N = 810, 45% response rate) were given clinical vignettes and asked questions regarding their view of client progress and subsequent treatment decisions. Despite clinicians reporting that verbal report is more influential in their actual clinical practice than outcome measure information, both sources of information had an equal impact on judgments of client change. Negative information (from either source) influenced clinicians more than positive information. Outcome measure information indicating client deterioration led more clinicians to choose to alter treatment than client verbal report of deterioration. Information indicating client improvement led some clinicians to continue treatment in the same manner as they had been. Insight‐oriented therapists were more likely to continue treatment‐as‐usual than were cognitive‐behavioral therapists. © 2005 Wiley Periodicals, Inc. J Clin Psychol 62: 325–337, 2006.
The Journal of Clinical Psychology, the next five years
Authors: Thorn Beverly E. 
Published: December 2005

AbstractThis is the first issue of the Journal of Clinical Psychology containing articles accepted under the current editorship (Beverly Thorn, Charles Ward, Stephen Saunders, and Mary Louise Cashel). As such, the Editor in Chief, Beverly Thorn, decided that it would be timely to offer brief editorial comments regarding the past year as the new EIC, recount a brief history of JCLP, and offer her vision statement for the Journal. © 2005 Wiley Periodicals, Inc. J Clin Psychol 62: 253–257, 2006.
Viral serotype and the transgene sequence influence overlapping adeno‐associated viral (AAV) vector‐mediated gene transfer in skeletal muscle
Authors: Ghosh Arkasubhra , Yue Yongping , Duan Dongsheng 
Published: December 2005

AbstractBackgroundThe overlapping approach was developed recently to expand the adeno‐associated viral (AAV) packaging capacity. In this approach, a gene is split into two partially overlapping fragments and separately packaged into an upstream and a downstream vector, respectively. Transgene expression is achieved in co‐infected cells after homologous recombination. Despite the promising proof‐of‐principle results in the lung, the efficiency has been very disappointing in skeletal muscle. Here we examined two potential rate‐limiting factors including AAV serotype and the transgene sequence.MethodsTo study serotype effect, we delivered AAV‐2, ‐5 and ‐6 overlapping vectors (5 × 108 vg particles of the upstream and the downstream vectors, respectively) and 5 × 108 vg particles of the intact gene vector to the tibialis anterior muscles of 7‐week‐old C57Bl/6 mice, respectively. To determine the effect of transgene sequence, we compared LacZ and alkaline phosphatase (AP) overlapping vectors. Transduction efficiency was quantified 6 weeks later by scoring the percentage of transgene‐positive myofibers.ResultsAAV‐2 overlapping vectors barely resulted in detectable transduction. Transduction efficiency was significantly improved in AAV‐5 and AAV‐6. The highest level was achieved in AAV‐6 that reached 42% and 96% of that of the intact gene vector for the LacZ gene and the AP gene, respectively. Surprisingly, AAV‐6 overlapping vector resulted in higher transduction than did AAV‐2 and AAV‐5 intact gene vectors.ConclusionsOur findings suggest that AAV serotype and the transgene sequence play critical roles in the overlapping approach. AAV‐6 holds great promise for overlapping vector‐mediated muscle gene therapy. Copyright © 2005 John Wiley & Sons, Ltd.
Evaluation of the reduction of imidazophenazine dye derivatives under fast‐atom‐bombardment mass‐spectrometric conditions
Authors: Kosevich Marina V. , Boryak Oleg A. , Orlov Vadim V. , Shelkovsky Vadim S. , Chagovets Vitalij V. , Stepanian Stepan G. , Karachevtsev Viktor A. , Adamowicz Ludwik 
Published: December 2005

AbstractSatellite [M + 2]+• and [M + 3]+ peaks accompanying the common peak of the protonated molecule [M + H]+ that are known to indicate the occurrence of a reduction process were observed in the fast atom bombardment (FAB) mass spectra of imidazophenazine dye derivatives in glycerol matrix. The distribution of the abundances in the [M + nH]+ peak group varied noticeably for different derivatives. This indicated different levels of the reduction depending on the different structure variations of the studied molecules. In the search for correlations between the mass spectral pattern and the structural features of the dyes, ab initio HF/6‐31++G** quantum chemical calculations were performed. They revealed that the abundances of the [M + 2]+• and [M + 3]+ ions show growth proportional to the decrease of the energy of the lowest unoccupied molecular orbital, i.e. proportional to the increase of the electron affinity of the dye molecule. A method for rapid screening of reductive properties of sets of dye derivatives on the basis of the FAB mass spectral data is discussed. Copyright © 2005 John Wiley & Sons, Ltd.
A validated positive chemical ionization GC/MS method for the identification and quantification of amphetamine, opiates, cocaine, and metabolites in human postmortem brain
Authors: Lowe Ross H. , Barnes Allan J. , Lehrmann Elin , Freed William J. , Kleinman Joel E. , Hyde Thomas M. , Herman Mary M. , Huestis Marilyn A. 
Published: December 2005

AbstractA sensitive and specific method for the simultaneous detection and quantification of amphetamine, opiates, and cocaine and metabolites in human postmortem brain was developed and validated. Analytes of interest included amphetamine, morphine, codeine, 6‐acetylmorphine, cocaine, benzoylecgonine, ecgonine methyl ester, ecgonine ethyl ester, cocaethylene, and anhydroecgonine methyl ester. The method employed ultrasonic homogenization of brain tissue in pH 4.0 sodium acetate buffer and solid phase extraction. Extracts were derivatized with N‐methyl‐N‐(tert‐butyldimethylsilyl) trifluoroacetamide and N,O‐bis(trimethylsilyl) trifluoroacetamide. Separation and quantification were accomplished on a bench‐top positive chemical ionization capillary gas chromatograph/mass spectrometer with selected ion monitoring. Eight deuterated analogs were used as internal standards. Limits of quantification were 50 ng/g of brain. Calibration curves were linear to 1000 ng/g for anhydroecgonine methyl ester and 6‐acetylmorphine, and to 2000 ng/g for all other analytes. Accuracy across the linear range of the assay ranged from 90.2 to 112.2%, and precision, as percent relative standard deviation, was less than 16.6%. Quantification of drug concentrations in brain is a useful research tool in neurobiology and in forensic and postmortem toxicology, identifying the type, relative magnitude, and recency of abused drug exposure. This method will be employed to quantify drug concentrations in human postmortem brain in support of basic and clinical research on the physiologic, biochemical, and behavioral effects of drugs in humans. Copyright © 2005 John Wiley & Sons, Ltd.
Characterization of must and wine of six varieties of grapes by direct infusion electrospray ionization mass spectrometry
Authors: Catharino Rodrigo R. , Cunha Ildenize B. S. , Fogaça Aline O. , Facco Elizete M. P. , Godoy Helena T. , Daudt Carlos E. , Eberlin Marcos N. , Sawaya Alexandra C. H. F. 
Published: December 2005

AbstractSamples of must derived from six different varieties of grapes taken during the fermentation process, as well as the respective wine samples directly after the end of the malolactic fermentation, were analyzed by direct infusion negative ion mode electrospray ionization mass spectrometry (ESI‐MS). Diagnostic ions for must were different from those of wine samples, although small variations for each of the grape varieties were also detected. The addition of unfermented must or sugar to wine could also be clearly detected. The spectra were acquired in a few minutes per sample, indicating that ESI‐MS can be used for high‐throughput analysis of samples and should prove useful for quality control during and after the fermentation process. Copyright © 2005 John Wiley & Sons, Ltd.
Rapid sequencing and disulfide mapping of peptides containing disulfide bonds by using 1,5‐diaminonaphthalene as a reductive matrix
Authors: Fukuyama Yuko , Iwamoto Shinichi , Tanaka Koichi 
Published: December 2005

AbstractMS/MS is indispensable for the amino acid sequencing of peptides. However, its use is limited for peptides containing disulfide bonds. We have applied the reducing properties of 1,5‐diaminonaphthalene (1,5‐DAN) as a MALDI matrix to amino acid sequencing and disulfide bond mapping of human urotensin II possessing one disulfide bond, and human guanylin possessing two disulfide bonds. 1,5‐DAN was used in the same manner as the usual MALDI matrices without any pre‐treatment of the peptide, and MS/MS was performed using a matrix‐assisted laser desorption/ionization quadrupole ion trap time‐of‐flight mass spectrometer (MALDI QIT TOFMS). The results demonstrated that MS/MS of the molecular ions reduced by 1,5‐DAN provided a series of significant b‐/y‐product ions. All 11 amino acid residues of urotensin II were identified using 1,5‐DAN, while only 5 out of 11 residues were identified using 2,5‐dihydroxybenzoic acid (DHB); similarly 11 out of 15 amino acid residues of guanylin were identified using 1,5‐DAN, while only three were identified using DHB. In addition, comparison of the theoretical and measured values of the mass differences between corresponding MS/MS product ions using 1,5‐DAN and DHB narrowed down the possible disulfide bond arrangement candidates. Consequently, 1,5‐DAN as a reductive matrix facilitates rapid amino acid sequencing and disulfide mapping for peptides containing disulfide bonds. Copyright © 2005 John Wiley & Sons, Ltd.
Novel acetylation‐aided migrating rearrangement of uridine‐diphosphate‐N‐acetylglucosamine in electrospray ionization multistage tandem mass spectrometry
Authors: Liu Hua‐Dong , Li Yan‐Mei , Du Jin‐Tang , Hu Jia , Zhao Yu‐Fen 
Published: December 2005

AbstractUridine 5′‐diphospho‐N‐acetylglucosamine (UDP‐GlcNAc) is the final product of hexosamine biosynthetic pathway (HSP) and the donor substrate for the modification of nucleocytoplasmic proteins at serine and threonine residues with N‐acetylglucosamine (GlcNAc) catalyzed by O‐GlcNAc transferase (OGT). Many analogs of UDP‐GlcNAc were designed to interfere with the process of protein O‐glycosylation by blocking OGT. A novel rearrangement reaction was observed in which phosphate‐N‐acetylglucosamine moiety migrated to 3′ terminus of ribose in ESI‐MSn of UDP‐GlcNAc. Results from tandem mass spectrometry, control experiments and calculation showed that the phosphate‐N‐acetylglucosamine migration might undergo a pentacoordinate phosphoric intermediate. Furthermore, the acetylation of glucosamine in UDP‐GlcNAc was essential in the migration process. Copyright © 2005 John Wiley & Sons, Ltd.