bluuebunny/crossref_metadata_2025_split huggingface dataset:
The antiinflammatory effect in rats of Chieh‐pu‐warn, a traditional chinese herbal preparation
Authors: Chang Chung‐Gwo , Chen Ming‐Chu , Yang Hsing‐Yi 
Published: October 2006

AbstractChieh‐pu‐warn (CPW), or Swift‐footed pill, is a traditional Chinese herbal preparation for the treatment of weakness, paralysis, or arthritis. Toxicity studies in mice showed that CPW at the maximal tested dosage (25 g/kg, p.o.) exhibited no acute toxicity. Subacute treatment of CPW with recommended daily dose (2.5 g/kg, p.o. daily for 15 days) showed that the body weight and the water content of lung, heart, kidney, and liver in mice were not changed significantly. The antiinflammatory effect of CPW was evaluated with carrageenin‐ and Freund's complete adjuvant‐induced edematous responses in the hind paws of rats. It was found that a single dose (2.5 g/kg, p.o.) of CPW had no significant antiinflammatory effect, but consecutive pretreatment with the same dose for three days significantly inhibited the carrageenin‐induced acute inflammation and Freund's complete adjuvant‐induced subacute inflammation in rats. The present results suggest that CPW has antiinflammatory activities with low toxicities.
Inhibition of A23187–induced release of leukotriene B4 in mouse whole blood Ex vivo and human polymorphonuclear cells in vitro by the cannabinoid analgesic cannabidiol
Authors: Formukong E. A. , Evans A. T. , Evans F. J. , Garland L. G. 
Published: October 2006

AbstractThe effects of CBD, a potent analgesic cannabinoid on LTB4 and TXB2 production stimulated by A23187 was determined in mouse blood ex vivo and in human polymorphonuclear cells in vitro. At a dose of 10 mg/kg administered orally CBD inhibited LTB4 production in mouse blood and was equieffective to the dual lipoxygenase/cyclo‐oxygenase inhibitor BW755C and the lipoxygenase inhibitor BWA4C used at a dose of 50 mg/kg. In the same blood samples CBD stimulated TXB2 production from between 20 to 30% over a 4 h period. A23187 stimulation of LTB4 synthesis in human polymorphonuclear cells was inhibited by CBD and Δ'‐THC in a dose related manner (IC505.4 and 8.2 μm respectively). However, only CBD produced a 100% inhibition of LTB4 synthesis. The production of TXB2 in these cells was initially stimulated at low doses by CBD but at higher doses TXB2 synthesis was inhibited.
Activity of delphinidin on microvascular damage models in rodents
Authors: Conti M. , Cristoni A. , Magistretti M. J. 
Published: October 2006

AbstractDelphinidin chloride (IdB 1056) was found to possess a significant activity by the intraperitoneal and oral routes in different experimental models of microvascular damage. It antagonized the increase in skin capillary permeability induced by histamine in rats and rabbits, by bradykinin and hyaluronidase in rats and by xylol in mice. Significant increases in skin capillary resistance were observed after a 3‐day oral dosing in guinea‐pigs and rats. A significant enhancement in cutaneous wound healing rate was found with a 10‐day oral treatment in rats made locally ischaemic. Delphinidin showed a low acute toxicity by the oral route.
The inhibitory effect of Sinomenine on immunological function in mice
Authors: Jun Wang , Pei‐Gen Xiao , Shi‐Ying Li , Ping Gao , Rui‐Hai Wang 
Published: October 2006

AbstractSinomenine, an alkaloid isolated from the stem of Sinomenium acutum (Thunb.) Rehd. et Wils., is reported to have clinically good curative effects on arthritis and rheumatoid arthritis. Our investigation has shown that sinomenine inhibits both the humoral and cellular immunity of mice. The weights of spleen and thymus of mice treated with sinomenine (50–150 mg/kg/d, i.p.) were drastically reduced. The antisheep red blood cell antibody production and delayed‐type hypersensitivity reaction induced by sheep red blood cells were inhibited by sinomenine at doses of 50, 100 and 150 mg/kg/d; and the survival time of split‐heart transplants was also prolonged. In vitro, sinomenine suppressed the proliferation of splenic cells stimulated with LPS and ConA. These immunosuppressive actions of sinomenine afford a reasonable explanation for its clinical effects in the treatment of arthritis and rheumatoid arthritis.
Standard allicin adsorbates on silicates
Authors: Jaeger W. , Koch H. P. , Pfaff K. 
Published: October 2006

AbstractThis communication is a warning to potential users of allicin, which is adsorbed on silicate carriers, to be used either as an analytical standard or as a source of allicin for biological experiments. Preparations of this type are invalid as calibrators, since they do not liberate their allicin content quantitatively and unchanged.
A clinical appraisal of Anacyclus pyrethrum root extract in dental patients
Authors: Patel V. K. , Patel Rupal V. , Venkatakrishna‐Bhatt H. , Gopalakrishna G. , Devasankariah G. 
Published: October 2006

AbstractTwo hundred dental patients were subjected to a double blind study following oral surgery for comparing the activity of an alcoholic extract of the roots of A. pyrethrum (2% alcohol extract, freshly dissolved in sterile distilled water) with xylocaine. The strength of anaesthesia, its effect on surgery, post‐operative recovery and wound healing were studied. The plant extract was found useful and safe at lower concentrations (less than 2%), not showing any side effects and facilitated anaesthesia for prolonged oral reconstructive surgery when compared wity xylocaine.
Haemodynamic effects of magnesium lithospermate B in rats with renal failure
Authors: Yokozawa Takako , Lee Tae Woong , Oura Hikokichi , Zhang Xiao Ying , Hattori Masao , Nonaka Gen‐Ichiro , Nishioka Itsuo 
Published: October 2006

AbstractA study was performed to investigate the haemodynamic effects of magnesium lithospermate B in rats with renal failure. Urinary excretion of sodium and potassium was significantly increased by administration of magnesium lithospermate B. Blood pressure was significantly lower in the magnesium lithospermate B‐treated group, compared with the control group. In addition, renal tissue blood flow and cerebral blood flow were significantly higher in the magnesium lithospermate B‐treated group, with significantly reduced renal vascular resistance and cerebral vascular resistance compared with the control group. These results confirm that magnesium lithospermate B reduces renovascular hypertension by improving urinary electrolyte excretion and haemodynamics.
Effects of Alcea pallida L. (A.) and Tilia argentea Desf. ex DC infusions on swimming performance in mice
Authors: Aydin S. , Öztürk Y. , Başer K. H. C. , Kirimer N. , Kurtar‐Öztürk N. 
Published: October 2006

AbstractIn Turkish folk medicine, Alcea pallida L. (A.) and Tilia argentea Desf. ex DC have been used for various purposes, such as expectorant, sedative, diuretic, diaphoretic, sedative activities etc. Since some of the folkloric uses may be related to anti‐stress (adaptogenic) activity, the effects of fresh infusions of A. pallida and T. argentea on mouse swimming performance were investigated. On the basis of our findings, these two plants prolonged the swimming time, suggesting an antistress (adaptogenic) activity.
Pharmacological evaluation of natural product analogues. I. Preliminary pharmacological evaluation of O‐methylgortschakoine and O‐methylpetaline
Authors: Al‐Azizi M. M. , El‐Olemy M. M. , Al‐Harbi M. M. 
Published: October 2006

AbstractThe synthesis of O‐methylgortschakoine and O‐methylpetaline was achieved through an unambiguous route. Pharmacological testing of O‐methylgortschakoine in comparison to papaverine and 7,8‐dimethoxy‐N‐methyltetrahydroisoquinoline, indicated that it possesses hypotensive, neuromuscular blocking and smooth muscle relaxant activities. 7,8‐Dimethoxy‐N‐methyltetrahydroisoquinoline showed only nonspecific smooth muscle relaxation in our testing system. The 1‐(p‐methoxybenzyl)‐substituent of O‐methylgortschakoine appears to be required for this hypotensive and neuromuscular blocking effect. The quaternary analogue O‐melthylpetaline was found to possess a more potent neuromuscular blocking activity.
Antibacterial diterpenes from the leaves and seeds of Juniperus excelsa M. Bieb
Authors: Muhammad I. , Mossa J. S. , El‐Feraly F. S. 
Published: October 2006

AbstractTwo diterpenes from Juniperus excelsa, obtained by bioautography‐guided isolation technique, were found to possess significant antibacterial activity in a two‐fold serial dilution assay. (+)‐Ferruginol (abieta‐8,11,13‐triene‐12‐ol) (1) and (−)‐sandaracopimeric acid (isopimara‐8(14), 15‐diene‐18‐oic acid) (2) exhibited significant activity against Bacillus subtilis, Staphylococcus aureus and Streptococcus durans, while their corresponding 3β‐hydroxy derivatives [(hinokiol (3) and 3β‐hydroxysandaracopimeric acid (4), also isolated from J. excelsa)] were found to be inactive. (+)‐Ferruginol, in addition, demonstrated strong activity against Mycobacterium smegmatis, M. intracellulare, M. xenopi and M. cheloni. The minimum inhibitory concentrations were determined for all compounds isolated from the active bioautographic zones, and were compared to those of the standard antibiotics chloramphenicol and streptomycin sulphate.
Restoration of radiation injury in mice by two Chinese medicinal prescriptions Kuei‐Pi‐Tang and Jen‐Sheng‐Yang‐Yung‐Tang
Authors: Hsu Hsue‐Yin , Lin Chun‐Ching , Hau Dou‐Mong 
Published: October 2006

AbstractA comparison of Kuei‐Pi‐Tang and Jen‐Sheng‐Yang‐Yung‐Tang, two traditional Chinese medicines, on promoting the recovery of mice from radiation‐induced damage was studied by using the measurements of colony forming stem cells in spleen, the appearance of occult blood in feces and changes of hemograms after x‐irradiation. Different sequences of x‐irradiation were studied with or without drug administration in groups of ICR strain mice which were intraperitoneally injected at a concentration of 10 or 20 mg/20 g body weight, once a day for 7 consecutive days. Kuei‐Pi‐Tang showed no significant difference on the efficacy of recovery from hemorrhage and hemograms, as compared with that of Jen‐Sheng‐Yang‐Yung‐Tang. In contrast, the effect of Kuei‐Pi‐Tang on the recovery of CPUs was more likely induced by eliminating the radiosensitivity of bone marrow cells. However, Jen‐Sheng‐Yang‐Yung‐Tang appears to increase the radiotolerance of the cells. The recovery of thrombocyte counts which was reported to have an important influence on the survival ratio coincided with that of the recovery from hemorrhage.
The influence of pollen extracts (cernitin GBX and Cernitin T60) on allergic reactions
Authors: Samochowiec L. , Dutkiewicz T. , Wójcicki J. , Giełdanowski J. 
Published: October 2006

AbstractThe influence of pollen extracts (Cernitin GBX and Cernitin T60) on some allergic reactions in animals and on the degranulation of mast cells and liberation of histamine has been studied. It was found that the cernitins possess antiallergic properties in vivo and in vitro. Both pollen preparations were able to inhibit the degranulation of mastocytes and histamine release from these cells. The results indicate that antiallergic properties of the cernitins might be dependent on their interaction with the mastocyte.
Hypoglycaemic activity of Spathodea campanulata stem bark decoction in mice
Authors: Niyonzima G. , Scharpé S. , Van Beeck L. , Vlietinck A. J. , Laekeman G. M. , Mets T. 
Published: October 2006

AbstractDecoction of the stem bark of Spathodea campanulata (SC) exerted a hypoglycaemic activity in streptozotocin (SZ) diabetic mice. Later, the decoction, washed with chloroform, was divided in water and butanol fractions. Both had a hypoglycaemic activity but were devoid of any influence on insulin levels in SZ diabetic mice. The decoction also decreased blood glucose levels in a glucose tolerance test (GTT) in normal mice.
In Vitro and In Vivo leishmanicidal activities of natural and synthetic quinoids
Authors: Sauvain Michel , Dedet Jean‐Pierre , Kunesch Nicole , Poisson Jacques , Gantier Jean‐Charles , Gayral Philippe , Kunesch Gerhard 
Published: October 2006

AbstractThe activities of various compounds isolated from plants traditionally used against leishmaniasis in populations from the tablelands of the Guyanas have been examined. The leishmanicidal activity of plant extracts was evaluated by in vitro testing on promastigote and amastigote stages of Leishmania amazonensis and by in vivo tests on L. amazonensis in mice. The leaves of Jacaranda copaia (Aublet) D. Don yielded two compounds: ursolic acid and jaracanone. Ursolic acid showed an interesting activity in vitro with an ED50 against amastigotes of 0.02 mM and no toxicity to macrophages at twice this dose. Jacaranone displayed a marked activity against promastigotes in vitro with an ED50 of 0.02 mM. Both compounds have weak in vivo antileishmanial activity. Similar synthetic compounds such as quinol and quinone acetates were prepared and showed increased activity in experimental cutaneous leishmaniasis in mice.
Inhibitory effect of edible plant extracts on 12‐O‐tetradecanoylphorbol–13‐acetate‐induced ear oedema in mice
Authors: Yasukawa K. , Yamaguchi A. , Arita J. , Sakurai S. , Ikeda A. , Takido M. 
Published: October 2006

AbstractWe report that spice, vegetable and fruit extracts inhibit 12–O‐tetradecanoylphorbol–13‐acetate (TPA)‐induced ear oedema in mice. About 100 methanol extracts obtained from spices, vegetables and fruits were assayed and their inhibition ratios calculated. In general, the spice extracts were more effective inhibitors than vegetable and fruit extracts. The methanol extracts of hop, stevia, cinnamon, turmeric, mate, mint, New Zealand spinach, watercress, tomato and seedling of radish markedly inhibited the inflammatory activity induced by TPA in mice. Two active compounds, humulone and lupeol 3‐palmitate were separated from hop and stevia, respectively.
Influence of Padma 28 on patients with chronic active hepatitis B
Authors: Gładysz Andrzej , Juszczyk Jacek , Brzosko Witold J. 
Published: October 2006

AbstractThirty‐four patients with chronic active hepatitis B (CAH‐B) were treated with Padma 28, a herbal remedy with immunocorrective properties. The patients were monitored by clinical and biochemical testing, as well as by serological, immunological and histological techniques. After treatment lasting 1 year 26 of 34 patients (76.5%) improved or normalized in biochemical parameters as well as in total T‐cell count (CD3) and CD4/CD8 index. An improvement in histology was seen in 19 patients (55.9%). An influence of Padma 28 on the serological markers of HBV infection was seen in 26 of 34 patients (76.5%). Six patients of 34 eliminated HBsAg (17.6%) and four of them seroconverted to anti‐HBs. Eleven patients eliminated HBeAg and HBV‐DNA, and eight of them seroconverted to anti‐HBe. Eight patients with persistent HBs and HBe‐antigenaemia had a decreased titre of HBsAg and HBeAg. In eight patients (23.5%) no influence of Padma 28 on serological markers of HBV infection was seen throughout the observation period. These observations indicate that treatment with Padma 28 of patients with CAH‐B fulfils two of the most important tasks for drug therapy of the disease, it influences the activity of genes of HBV and stops the progression of liver inflammation.
Capsaicin action modulates lipid peroxidation induced by different irritants
Authors: De Amit Krishna , Ghosh Jagat Jiban 
Published: October 2006

AbstractCapsaicin (8‐methyl‐n‐vanillyl‐6‐nonenamide), the pungent principle of red hot pepper, has been reported to cause ‘activation’ followed by ‘desensitization’ of the tissue against various types of irritant induced damage, on short‐ and long‐term application respectively. This review discusses one aspect of the mechanism of capsaicin induced activation followed by desensitization by discussing the modulatory effects of capsaicin on lipid peroxidative changes caused by different irritants (e.g. gaseous, chemical and radiation).
Antidiabetic and adaptogenic properties of Momordica charantia extract: An experimental and clinical evaluation
Authors: Srivastava Y. , Venkatakrishna‐Bhatt H. , Verma Y. , Venkaiah K. , Raval B. H. 
Published: October 2006

AbstractThe hypoglycaemic properties of Mormodica charantia (bitter gourd) water extract was tested on alloxan diabetic rats experimentally. A fall of blood sugar after 3 week's treatment with aqueous extract of fruits of the herb was found to be significant (p<0.01). The aqueous extract of fruit was more effective in diabetes (fall of blood sugar 54% after 3 week's therapy) than the powder of the dried fruit (fall 25% nonsignificant). Hypoglycaemic effects in diabetic patients were found to be highly significant (p<0.01) at the end of the trial but were cumulative and gradual, unlike that produced by insulin. Adaptogenic properties are indicated by the delay in the appearance of cataracts, the secondary complications of diabetes and relief in neurological and other common symptoms even before the hypoglycaemia occurred.
The antiinflammatory and liver protective effect of Tithonia diversifolia (Hemsl.) gray and Dicliptera chinensis Juss. Extracts in rats
Authors: Lin Chun‐Ching , Lin Min‐Lin , Lin Jer‐Min 
Published: October 2006

AbstractThe antiinflammatory and liver protective effect of water extracts of Tithonia diversifolia (Hemsl.) Gray (aerial part), T. diversifolia (stem) and Dicliptera chinensis Juss. (aerial part) against paw oedema induced by carrageenan and acute hepatic damage induced by CCI4 were determined in rats. The results indicated that treatment with a water extract of the aerial part of T. diversifolia decreased the paw oedema induced by carrageenan (p < 0.001) and the GOT, GPT level elevation caused by CCI4 were reduced (p < 0.01). The pathological changes of hepatic lesions caused by CCI4 were improved by treatment with the drug extracts mentioned above.
Effects of flavonoids from licorice roots (Glycyrrhiza inflata Bat.) On arachidonic acid metabolism and aggregation in human platelets
Authors: Kimura Yoshiyuki , Okuda Takuo , Okuda Hiromichi 
Published: October 2006

AbstractThe effects of six flavonoids isolated from Sinkiang Licorice roots (lichochalcones A and B, isoliquiritigenin, isoliquiritin, liquiritigenin and liquiritin) on arachidonate metabolism and aggregation in human platelets were studied. Licochalcones A and B at concentrations of 10−5M to 10−3M inhibited the formation of 12‐hydroxy‐5,8,10‐heptadecatrienoic acid (HHT) and thromboxane B2 (TXB2), does‐dependently. Furthermore, isoliquiritigenin and liquiritigenin at higher concentrations (10−4M–10−3M) inhibited the formation of HHT and TXB2, while they increased the formation of 12‐hydroxy‐5,8,10,14‐eicosatetraenoic acid (12‐HETE). However, isoliquiritin and liquiritin had no effect on arachidonate metabolism. Licochalcones A and B inhibited thrombin‐induced platelet aggregation at concentrations of 2 × 10−5M to 2 × 10−4M. Isoliquiritigenin, liquiritigenin, isoliquiritin and liquiritin had no effects on the thrombin‐induced aggregation. To clarify the inhibitory effects of flavonoids in licorice roots on the formation of HHT and TXB2 and thrombin‐induced aggregation, we studied the effects of flavonoids on cytosolic free calcium concentrations ([Ca2+]i) induced by thrombin. The results showed that licochalcones A and B inhibited the elevation of [Ca2+]i induced by thrombin, dose‐dependently.
Cytostatic activity against HEp‐2 cells and antibacterial activity of essential oil from Helichrysum picardii
Authors: de la Puerta R. , Sáenz M. T. , García M. D. 
Published: October 2006

AbstractDifferent samples of essential oil from Helichrysum picardii Boiss. & Reuter (Compositae) collected at the beginning of each season from the same locality have been tested for their cytostatic and antimicrobial activity. All the oil samples showed a stronger in vitro activity against HEp‐2 cells than a 6‐mercaptopurine solution used as a positive control. Gram‐positive bacteria as well as the fungus Candida albicans were sensitive to the action of the essential oil, whereas none of the samples showed activity against the gram‐negative bacteria.
Evaluation of the molluscicidal properties of Myrtus communis L. (Myrtaceae)
Authors: Deruaz D. , Reynaud J. , Raynaud J. 
Published: October 2006

AbstractCrude water extract and a flavonoid fraction of Myrtus communis were found to possess molluscicidal activity against the aquatic snail Biomphalaria glabrata involved in the transmission of schistosomiasis.
Cellular mechanisms of biological aging
Authors: Yu Byung P. 
Published: October 2006

AbstractCellular aging is considered to be caused by the physiological deterioration in the homeostatic regulatory process which is essential for the proper maintenance of cellular function. Although among numerous theories of aging proposed in the past, the cellular mechanism underlying the age‐dependent deterioration is not well defined. Currently two modern hypotheses, free radical and glycation are most popular among gerontologists. This review discusses the involvement of free radicals and glycation process in aging as possible cellular mechanisms with a new proposal on their synergistic interactions through a common pathway of free radical generation by glycation process.
Neuroprotective effect of Toki‐Shakuyaku‐San (TJ‐23) on hypoglycaemia/hypoxia‐induced neuronal damage in rat striatal slices
Authors: Kataoka Yasufumi , Kouzuma Masami , Koizumi Shuichi , Niwa Masami , Taniyama Kohtaro , Fujiwara Michihiro 
Published: October 2006

AbstractThe effect of Toki‐Shakuyaku‐San (TJ‐23) was examined on various models of brain damage in vitro. TJ‐23 (10 mg/mL) significantly protected striatal slices from dysfunction induced by high K+ and BAY K‐8644 but not from that by L‐glutamate and N‐methyl‐D‐aspartate, an effect which was similar to that of nifedipine, a Ca2+ antagonist. The present findings, therefore, raised the possibility that TJ‐23 expressed a neuroprotective action on hypoxia/ischaemia‐induced brain damage by inhibiting an excess Ca2+ entry through voltage‐gated Ca2+ channels.
In vitro antimalarial activity, chloroquine potentiating effect and cytotoxicity of alkaloids of Hernandia voyronii Jum. (Hernandiaceae)
Authors: Ratsimamanga‐Urverg S. , Rasoanaivo P. , Milijaona R. , Rakotoarimanga J. , Rafatro H. , Robijaona B. , Rakoto‐Ratsimamanga A. , Verdier F. , le Bras J. 
Published: October 2006

AbstractHernandia voyronii is traditionally used as adjuvant to chloroquine in Madagascar. Neutral and basic alkaloidal extracts of this plant were evaluated for their intrinsic in vitro antimalarial activity, cytotoxicity and chloroquine potentiating action against the chloroquine resistant Plasmodium falciparum strain FCM29. Bioassay directed fractionation clearly demonstrated that both the intrinsic antimalarial activity and the chloroquine potentiating action was localized in the polar alkaloidal extract. Moreover, this extract had low cytotoxicity to HeLa cells and L929 fibroblasts. These results support the traditional use of H. voyronii as an antimalarial and adjuvant to chloroquine.
Oestrogenic rhythm induced by a single administration of the extract of Ferula jaeschkeana to immature rats
Authors: Prakash A. O. , Pathak Sandhya , Shaiv Amita , Mathur R. 
Published: October 2006

AbstractThe hexane extract of Ferula jaeschkeana was studied for its effects on the oestrogenic rhythm following a single administration to immature rats. A 25 mg/kg single oral dose significantly increased the uterine wet weight and caused premature opening of the vagina and induced vaginal cornification. A uterotrophic peak was attained 2 days after administration and thereafter declined gradually. At 10 days, values became almost normal. A significant amount of glycogen was estimated in the uterus during the first 5 days after administration and thereafter decreased significantly. Histoarchitecture of the uterus showed a stimulated endometrium which continued for 6–8 days only. The oestrogenic rhythm induced by the hexane extract was compared with that following diethylstilbesterol administration.