bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rationally Designed Ionically Conductive Metal‐Organic Frameworks for Ultrasensitive Methamphetamine Analogs Sensor
Authors: Xiong Chonghao , Li Li , Yang Menghao , Chen Ying , Wang Lu , Xiong Lize , Huang Jia , Zou Yidong 
Published: March 2024

AbstractAchieving convenient, sensitive, low‐cost, and non‐contact detection of trace addictive drugs is a challenging problem. Herein, a novel ionically conductive metal‐organic framework (IC‐MOFs) is designed through a controlled interface assembly strategy. The active metal anions are incorporated into the layered MOFs with a porous structure, forming charge carriers that served as effective adsorption/binding sites for N‐methylphenethylamine (MPEA), a crucial simulator of addictive drugs. The in situ integrated Zn3(HHTP)2‐MOF sensor device designed in this study demonstrated real‐time detection of sub‐ppb level MPEA at room temperature, with an exceptionally low theoretical detection limit of 20 ppt. The overall sensing performance of this sensor surpassed all previously reported chemical sensors for detecting methamphetamine. The Zn3(HHTP)2‐MOF sensor exhibited outstanding selectivity, rapid response time (ca. 5 s), excellent long‐term stability, amenable miniaturization, and device consistency. The device successfully passed dual 85 test (500 h at 85 °C and 85% of humidity), which is rarely report previously. Density functional theoretical calculations (DFT) and spectral characterization confirmed that the prominent selectivity of Zn3(HHTP)2‐MOF toward MPEA is attributed to the strong binding ability. The general and straightforward strategy provides brand‐new route to exploiting smart sensors for drug prevention and surveillance.
Preoperative serum cholinesterase as a prognostic factor in patients with colorectal cancer
Authors: Nakamura Kimihiko , Seishima Ryo , Matsui Shimpei , Shigeta Kohei , Okabayashi Koji , Kitagawa Yuko 
Published: March 2024

AbstractAimSerum cholinesterase (ChE) levels are considered to reflect nutritional status. Although ChE has been well documented as a prognostic factor for some cancers, no clear consensus on its use for colorectal cancer (CRC) has been reached. The aim of this study was to investigate the relationship between preoperative serum ChE and postoperative long‐term prognosis in CRC patients.MethodsA total of 1053 CRC patients who underwent curative surgery were included in this study. The correlations between the preoperative ChE value and overall survival (OS) or cancer‐specific survival (CSS) were assessed. By dividing patients into two groups according to their ChE value, OS and CSS were compared between the groups.ResultsMultivariate analysis revealed that the continuous ChE value was a significant predictor of OS (hazard ratio, 0.996; 95% CI, 0.993–0.998; p = 0.002) and CSS (hazard ratio, 0.994; 95% CI, 0.991–0.998; p = 0.001), independent of other variables. The low‐ChE (≤234 U/L) group had a significantly poorer prognosis than the high‐ChE (>234 U/L) group for both OS (5‐year OS for low ChE and high ChE: 79.8% and 93.3%, respectively; p < 0.001) and CSS (5‐year CSS for low ChE and high ChE: 84.8% and 95.6%, respectively; p < 0.001).ConclusionsLower preoperative serum ChE levels are a predictive factor of poor prognosis for CRC patients. As serum ChE levels can be measured quickly and evaluated easily, ChE could become a useful marker for predicting the postoperative long‐term outcomes of CRC patients.
Risk factors of mortality following hospital admission for Crohn's disease: A cohort study at a tertiary referral center in Taiwan
Authors: Huang Po‐Han , Lin Wey‐Ran , Le Puo‐Hsien , Lin Cheng‐Yu , Chen Chun‐Wei , Wu Ren‐Chin , Hsu Jun‐Te , Tsai Wen‐Sy , Lai Ming‐Wei , Hsieh Sen‐Yung , Su Ming‐Yao , Chiu Cheng‐Tang , Kuo Chia‐Jung 
Published: March 2024

AbstractThe prevalence and incidence of Crohn's disease (CD) in Asia is rising, and it is important to know the risk factors of mortality. In our study, CD patients diagnosed and treated in the Chang Gung Memorial Hospital Linkou branch were enrolled from January 1989 to October 2019. The collected data included age, sex, disease duration, location and behavior of the disease, biochemical parameters at admission, medication history, surgical history, and comorbidities. The mean age at diagnosis was 35.7 ± 16.1 years old and the male‐to‐female ratio was 2.4. The penetrating type of CD was the most common (41.3%) of disease behavior. The ileocolonic area is the most common location of disease involvement (79%). 7.7% of patients had low serum albumin levels (<3 g/dL). 16.8% of patients had hemoglobin levels less than 10 g/dL. Of the patients included, 4 died during the follow‐up period. Low serum albumin levels at admission (p = .0307) are an independent predictor for mortality. In conclusion, it is important in perioperative care, especially for CD patients with hypoalbuminemia.
Pure Spin Transport in YIG Films with Amorphous‐to‐Crystalline Transformation
Authors: Yu Rui , Cao Jiefeng , Liu Haigang , Zhu Fangyuan , Meng Xiangyu , Long Zhipeng , Li Junqin , Wang Yong 
Published: March 2024

AbstractMagnetic insulators, especially Y3Fe5O12 (YIG), are considered promising candidates for spin‐based device applications due to their ultralow damping, high spin injection efficiency, and long‐distance spin propagation. However, these intriguing features are widely studied based on crystallization YIG films. Pure spin phenomena, like spin transport in YIG films with structural evolution, remain unclear. Herein, pure spin transportation is systematically investigated in the sandwich structure formed by YIG, the inserted layer‐nominal YIG (n‐YIG) with a varied crystalline structure and heavy metal Platinum (Pt). By applying ferromagnetic resonance (FMR)‐driven inverse spin Hall effect (ISHE) measurement, the detected ISHE voltage signal presented a strong correlation with the thickness of n‐YIG and its crystalline phase. A significant increasement in spin transportation is obtained for the crystallized n‐YIG via a high‐temperature annealing. These results demonstrate that pure spin current is transported availably in the structural evolution of YIG films. Furthermore, the element‐specific X‐ray absorption spectroscopy (XAS) and X‐ray magnetic circular dichroism (XMCD) spectra on the n‐YIG films showed a distinction for the crystallized n‐YIG which indicates that the spin propagation is correlated to its magnetic order. These findings are instructive for low‐dissipation spin‐based devices.
A bothremydid turtle (Pleurodira) from the middle Cenomanian of Vale de Figueira (Belas, Portugal)
Authors: Antunes Miguel Telles , Pérez‐García Adán 
Published: March 2024

AbstractAn unpublished turtle shell from the middle Cenomanian of Vale de Figueira, near Belas (Lisbon District, Portugal), is recognized by us as collected in 1880 under the direction of Carlos Ribeiro. No turtle remains from that region had so far been figured, described or discussed from a systematic point of view. The specimen corresponds to a partial but articulated shell. It is attributed to Pleurodira and, more specifically, to Bothremydidae. Only one pre‐Campanian turtle specimen was previously identified at the infrafamilial level in the Cretaceous record of Portugal. It was a partial shell from the middle Cenomanian of Nazaré (Leiria District) attributed to the bothremydid Algorachelus peregrina, a species defined in a Spanish synchronous locality (Algora, in Central Spain). Several anatomical regions in the specimen from Vale de Figueira were not preserved in the partial carapace from Nazaré, and differences in the morphology of some elements are recognized between both shells. However, the individual studied here is also ascribed to Algorachelus peregrina, these differences being justified by intraspecific variability. Therefore, the specimen represents the second evidence on the species in Portugal, being the only one recognized for the Lisbon District.
Boron compounds are effective on Tribolium castaneum (Coleoptera: Tenebrionidae): Reduced lipogenesis and induced body weight loss
Authors: Atay Turgut , Ertürk Sait , Alkan Mustafa , Kordali Şaban , Yılmaz Ferah , Barış Aydemir , Ghanbari Solmaz , Doğan Cansu , Toprak Umut 
Published: March 2024

AbstractIn the current study, we investigated the insecticidal efficacy of two borates, disodium octaborate tetrahydrate (Etidot‐67) and calcium metaborate (CMB) via surface application or diet delivery on the red flour beetle, Tribolium castaneum (Herbst, 1797) (Coleoptera: Tenebrionidae). The application method did not change the boron‐related mortality, but CMB was more effective than Etidot‐67. At the highest dose, it took around 13 days to reach the highest mortality (≥98.1%) for CMB, while it was 19 days for Etidot‐67 (≥95.8%). Both boron compounds led to a significant reduction in triglyceride levels in parallel to the downregulation of acetyl‐CoA carboxylase (ACC) and fatty acid synthase (FAS), the two primary genes involved in de novo lipogenesis, while they also induced body weight loss. In conclusion, the current study indicated the insecticidal potential of boron compounds but CMB is more promising and more effective in controlling T. castaneum, while lipogenesis is inhibited and weight loss is induced by boron compounds.
Genome‐wide identification of cuticle protein superfamily in Frankliniella occidentalis provide insight into the control of both insect vectors and plant virus
Authors: Zheng Yang , Feng Yinghao , Li Zhejin , Wang Junwen 
Published: March 2024

AbstractThe structural cuticle proteins (CPs) play important roles in the development and fitness of insects. However, knowledge about CP gene superfamily is limited in virus‐transmitting insect vectors, although its importance on transmission of plant virus has been gradually emphasized. In this study, the genome‐wide identification of CP superfamily was conducted in western flower thrips Frankliniella occidentalis that is the globally invasive pest and plant virus vector pest. The pest transmits notorious tomato spotted wilt virus (TSWV) around the world, causing large damage to a wide array of plants. One hundred and twenty‐eight F. occidentalis CP genes (FoCPs) were annotated in this study and they were classified into 10 distinct families, including 68 CPRs, 16 CPAP1s, 6 CPAP3s, 2 CPCFCs, 10 Tweedles, 4 CPFs, 16 CPLCPs, and 6 CPGs. The comprehensive analysis was performed including phylogenetic relationship, gene location and gene expression profiles during different development stages of F. occidentalis. Transcriptome analysis revealed more than 30% FoCPs were upregulated at least 1.5‐fold when F. occidentalis was infected by TSWV, indicating their potential involvement in TSWV interactions. Our study provided an overview of F. occidentalis CP superfamily. The study gave a better understand of CP's role in development and virus transmission, which provided clues for reducing viral damages through silencing CP genes in insect vectors.
Measuring the retrievability of digital library content using analytics data
Authors: Jahani Hamed , Azzopardi Leif , Sanderson Mark 
Published: March 2024

AbstractDigital libraries aim to provide value to users by housing content that is accessible and searchable. Often such access is afforded through external web search engines. In this article, we measure how easily digital library content can be retrieved (i.e., how retrievable) through a well‐known search engine (Google) using its analytics platforms. Using two measures of document retrievability, we contrast our results with simulation‐based studies that employed synthetic query sets. We determine that estimating the retrievability of content given a Digital Library index is not a strong predictor of how retrievable the content is in practice (via external search engines). Retrievability established the notion that search algorithms can be biased. In our work, we find that while there such bias is present, much of the variation in retrievability appears to be strongly influenced by the queries submitted to the library, a side of retrievability less examined in past work.
Recent advances in the development and applications of luminescent bacteria–based biosensors
Authors: Li Yingying , Zhao Yuankun , Du Yiyang , Ren Xuechun , Ding He , Wang Zhimin 
Published: March 2024

AbstractLuminescent bacteria–based biosensors are widely used for fast and sensitive monitoring of food safety, water quality, and other environmental pollutions. Recent advancements in biomedical engineering technology have led to improved portability, integration, and intelligence of these biotoxicity assays. Moreover, genetic engineering has played a significant role in the development of recombinant luminescent bacterial biosensors, enhancing both detection accuracy and sensitivity. This review provides an overview of recent advances in the development and applications of novel luminescent bacteria–based biosensors, and future perspectives and challenges in the cutting‐edge research, market translation, and practical applications of luminescent bacterial biosensing are discussed.
Exploring in the classroom the relationship between alcohol intake and behavioral disorders through an animal model
Authors: Hernández‐García Samanta , Guerrero‐Rubio M. Alejandra , Henarejos‐Escudero Paula , Martínez‐Rodríguez Pedro , Gandía‐Herrero Fernando 
Published: March 2024

AbstractAlcohol consumption has profound effects on behavior, such as impaired judgment, addiction or even death. It is estimated that alcohol contributes to around three million deaths worldwide, 13.5% of them in young people with ages between 20 and 39 years. Consequently, it is necessary to raise awareness among college and high school students of the risk related to alcohol drinking. The small nematode Caenorhabditis elegans is an animal widely used as a model organism to study nearly all aspects of Biochemistry. It is a powerful tool to test the potential bioactivity and molecular mechanisms of natural compounds and drugs in vivo. Therefore, it is an interesting topic to include in an undergraduate course of Biotechnology, Biochemistry or Biology students among other scientific vocations. C. elegans is also used as a neurobiological model to evaluate substances' neurotoxicity and behavioral effects. The proposed experiment introduces students to the handling of this preclinical model and to the evaluation of behavioral alterations induced by chemicals in scientific research. The effects of different doses of ethanol on C. elegans behavior are studied using a versatile chemotaxis assay. This laboratory experiment is suitable for an undergraduate course. The practical session can be used in the global strategies of information and awareness of educational centres to mitigate the impact of alcohol abuse among students, both in formal courses or in Science fairs or exhibitions.
Therapeutic and risk relevance of psychopathy and general criminal attitude change in an institutional sexual offense treatment program
Authors: Augustyn Carissa M. , Olver Mark E. 
Published: March 2024

AbstractWe examined the interrelationships between psychopathy, changes in general criminal attitudes, and community recidivism in a sample of 212 men who attended an institutional sexual offense treatment program (SOTP) and were followed for an average of 12.73 years post‐release. The men completed a self‐report measure of general criminal attitudes, the Criminal Sentiments Scale, as part of routine SOTP service delivery, Psychopathy Checklist‐Revised (PCL‐R) ratings were completed via file review, and recidivism data were obtained from official criminal records. Criminal attitude endorsement and criminal attitude change had clinically meaningful, but differential, associations with the antisocial and interpersonal features of psychopathy. Further, positive changes in criminal attitudes—particularly tolerance of law violations (i.e., rationalizations for criminal behavior)—were significantly predictive of reductions in community violent and general recidivism after controlling for PCL‐R score. Results demonstrate that general criminal attitude change has risk relevance in the treatment of high psychopathy persons with sexual offense histories.
A phase Ib study evaluating the recommended phase II dose, safety, tolerability, and efficacy of mivavotinib in combination with nivolumab in advanced solid tumors
Authors: Juric Dejan , Barve Minal , Vaishampayan Ulka , Roda Desamparados , Calvo Aitana , Jañez Noelia Martinez , Trigo Jose , Greystoke Alastair , Harvey R. Donald , Olszanski Anthony J. , Opyrchal Mateusz , Spira Alexander , Thistlethwaite Fiona , Jiménez Begoña , Sappal Jessica Huck , Kannan Karuppiah , Riley Jason , Li Cheryl , Li Cong , Gregory Richard C. , Miao Harry , Wang Shining 
Published: March 2024

AbstractMivavotinib (TAK‐659/CB‐659), a dual SYK/FLT3 inhibitor, reduced immunosuppressive immune cell populations and suppressed tumor growth in combination with anti‐PD‐1 therapy in cancer models. This dose‐escalation/expansion study investigated the safety, pharmacokinetics, pharmacodynamics, and preliminary efficacy of mivavotinib plus nivolumab in patients with advanced solid tumors. Patients received oral mivavotinib 60–100 mg once‐daily plus intravenous nivolumab 3 mg/kg on days 1 and 15 in 28‐day cycles until disease progression or unacceptable toxicity. The dose‐escalation phase evaluated the recommended phase II dose (RP2D; primary endpoint). The expansion phase evaluated overall response rate (primary end point) at the RP2D in patients with triple‐negative breast cancer (TNBC). During dose‐escalation (n = 24), two dose‐limiting toxicities (grade 4 lipase increased and grade 3 pyrexia) occurred in patients who received mivavotinib 80 mg and 100 mg, respectively. The determined RP2D was once‐daily mivavotinib 80 mg plus nivolumab 3 mg/kg. The expansion phase was terminated at ~50% enrollment (n = 17) after failing to meet an ad hoc efficacy futility threshold. Among all 41 patients, common treatment‐emergent adverse events (TEAEs) included dyspnea (48.8%), aspartate aminotransferase increased, and pyrexia (46.3% each). Common grade ≥3 TEAEs were hypophosphatemia and anemia (26.8% each). Mivavotinib plasma exposure was generally dose‐proportional (60–100 mg). One patient had a partial response. Mivavotinib 80 mg plus nivolumab 3 mg/kg was well tolerated with no new safety signals beyond those of single‐agent mivavotinib or nivolumab. Low response rates highlight the challenges of treating unresponsive tumor types, such as TNBC, with this combination and immunotherapies in general.Trial registration IDNCT02834247.
The impact of COVID‐19 on mental health and well‐being of Latine youth from rural and agricultural families in the Midwest
Authors: Taylor Zoe E. , Carrizales Alexia , Carlo Gustavo , Herrera Fabiola , Reyes Olivya , Escobedo Jennifer , Burgos Genesis Santiago , Ruiz Yumary 
Published: March 2024

AbstractThe COVID‐19 pandemic had significant health and socioeconomic repercussions for Latine immigrant families and their children due to long‐standing social, economic, and immigration‐related inequities, with rural families particularly vulnerable. In particular, the mental health and well‐being of Latine youth may have been detrimentally impacted due to disproportionate family stressors and burdens. In the present study, we examined the effect of parent and youth COVID‐19 pandemic stress on youth mental health, and in turn, on youth well‐being using quantitative and qualitative data. Participants were Latine youth in rural and agricultural families in the US Midwest (N = 210, Mage = 12.10 years, 52.4% male, 36.2% first‐generation immigrants) and a primary caregiver (86.5% mothers, 92.7% first‐generation immigrant, mean income = 25‐30 K) as well as n = 19 dyadic qualitative interviews. Quantitative analyses revealed that both youth and primary caregiver COVID‐19 stressors were associated with youth mental health problems, and indirectly impacted five domains of youth well‐being (engagement, perseverance, optimism, connectedness, and happiness). Qualitative findings provided insights into how the COVID‐19 pandemic increased stress for mothers and children (e.g., job loss and economic hardship, COVID‐19 infection, online education challenges). The study demonstrates how the environmental context of the COVID‐19 pandemic shaped the individual and family‐level functioning of Latine immigrant families during this uniquely challenging time period.
The role of fat‐soluble vitamins in efferocytosis
Authors: Jamalvandi Mona , Khayyatzadeh Sayyed Saeid , Hayati Mohammad Javad , Gheibihayat Seyed Mohammad 
Published: March 2024

AbstractCell death and the efficient removal of dead cells are two basic mechanisms that maintain homeostasis in multicellular organisms. efferocytosis, which includes four steps recruitment, recognition, binding and signaling, and engulfment. Effectively and quickly removes apoptotic cells from the body. Any alteration in efferocytosis can lead to several diseases, including autoimmune and inflammatory conditions, atherosclerosis, and cancer. A wide range of dietary components affects apoptosis and, subsequently, efferocytosis. Some vitamins, including fat‐soluble vitamins, affect different stages of efferocytosis. Among other things, by affecting macrophages, they are effective in the apoptotic cleansing of cells. Also, polyphenols indirectly intervene in efferocytosis through their effect on apoptosis. Considering that there are limited articles on the effect of nutrition on efferocytosis, in this article we will examine the effect of some dietary components on efferocytosis.
From Criegee to Breslow: How π‐Donors Steer the Route of Olefin Ozonolysis
Authors: Medvedko Serhii , Wagner J. Philipp 
Published: March 2024

AbstractWhile π‐bonds typically undergo cycloaddition with ozone, resulting in the release of much‐noticed carbonyl O‐oxide Criegee intermediates, lone‐pairs of electrons tend to selectively accept a single oxygen atom from O3, producing singlet dioxygen. We questioned whether the introduction of potent electron‐donating groups, akin to N‐heterocyclic olefins, could influence the reactivity of double bonds – shifting from cycloaddition to oxygen atom transfer or generating lesser‐known, yet stabilized, donor‐substituted Criegee intermediates. Consequently, we conducted a comparative computational study using density functional theory on a series of model olefins with increasing polarity due to (asymmetric) π‐donor substitution. Reaction path computations indicate that highly polarized double bonds, instead of forming primary ozonides in their reaction with O3, exhibit a preference for accepting a single oxygen atom, resulting in a zwitterionic species formally identified as a carbene‐carbonyl adduct. This previously unexplored reactivity potentially introduces aldehyde umpolung chemistry (Breslow intermediate) through olefin ozonolysis. Considering solvent effects implicitly reveals that increased solvent polarity further directs the trajectories toward a single oxygen atom transfer reactivity by stabilizing the zwitterionic character of the transition state. The competing modes of chemical reactivity can be explained by a bifurcation of the reaction valley in the post‐transition state region.
Bimodal Glycosyl Donors as an Emerging Approach Towards a General Glycosylation Strategy
Authors: Warnes Matthew E. , Fascione Martin A. 
Published: March 2024

AbstractOrganic synthesis provides an accessible route to preparative scale biological glycans, although schemes to access these complex structures are often complicated by preparation of multiple monosaccharide building blocks. Bimodal glycosyl donors capable of forming both α‐ and β‐anomers selectively, are an emerging tactic to reduce the required number of individual synthetic components in glycan construction. This review discusses examples of bimodal donors in the literature, and how they achieve their stereocontrol for both anomers. Notable examples include a bespoke O‐2 benzyl protecting group, a strained glycal for reaction using organometallic catalysis, and a simple perbenzylated donor optimised for stereoselective glycosylation through extensive reaction tuning.