bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endoscopic treatment for early duodenal papillary carcinoma: long‐term outcomes
Authors: Wang Yingyu , Khizar Hayat , Zhou Haibin , Jin Hangbin , Lou Qifeng , Zhang Xiaofeng , Yang Jianfeng 
Published: March 2024

AbstractBackground and AimThis study aims to determine whether endoscopic papillectomy (EP) is a safe and effective treatment for early duodenal papillary carcinoma with long‐term follow‐up.MethodsFrom June 2012 to September 2022, 48 patients with early duodenal papilloma carcinoma who received endoscopic treatment were included. The histological types, percentage of complete resections, postoperative residuals, adverse events, and recurrences were evaluated.ResultsEP was successful in all patients; 46 were lumped, and two were fragmented, with a 95.8% intact removal rate (46/48). The preoperative biopsy pathological positive rate was 70.8% (34/48). The incidence of early postoperative adverse events (within 1 month after EP) were 16.7% (8/48), including four cases of acute pancreatitis, three cases of delayed bleeding, and one case of acute cholangitis. In addition, 4.2% (2/48) of the late adverse events were bile duct stenosis. After 6 months, the postoperative residual rate was 0%. The median time to recurrence was 17.5 months, and the postoperative recurrence rate was 16.7% (8/48) in patients treated with radiofrequency ablation. The median progression‐free survival was 18.6 months (95% CI, 12.1–25.1), and the median overall survival was 121.5 months (95% CI, 105.6–120.9).ConclusionsEP is a safe and efficient alternative therapy for early duodenal papillary carcinoma. Endoscopic follow‐up and treatment are essential because of the potential for recurrence.
Childhood obesity prevention trials: A systematic review and meta‐analysis on trial design and the impact of type 1 error
Authors: Padgett Louise , Stevens June , Summerbell Carolyn , Burton Wendy , Stamp Elizabeth , McLarty Laura , Schofield Holly , Bryant Maria 
Published: March 2024

SummaryEffect sizes from previously reported trials are often used to determine the meaningful change in weight in childhood obesity prevention interventions because information on clinically meaningful differences is lacking. Estimates from previous trials may be influenced by statistical significance; therefore, it is important that they have a low risk of type 1 error. A systematic review and meta‐analysis were conducted to report on the design of child obesity prevention randomized controlled trials and effectiveness according to risk of type 1 error. Eighty‐four randomized controlled trials were identified. A large range of assumptions were applied in the sample size calculations. The most common primary outcome was BMI, with detectable effect size differences used in sample size calculations ranging from 0.25 kg/m2 (followed up at 2 years) to 1.1 kg/m2 (at 9 months) and BMI z‐score ranging from 0.1 (at 4 years) to 0.67 (at 3 years). There was no consistent relationship between low risk of type 1 error and reports of higher or lower effectiveness. Further clarity of the size of a meaningful difference in weight in childhood obesity prevention trials is required to support evaluation design and decision‐making for intervention and policy. Type 1 error risk does not appear to impact effect sizes in a consistent direction.
Histopathology, mRNA expression profile, and donor‐derived cell‐free DNA for assessment of rejection in pediatric heart transplantation
Authors: O'Halloran Conor P. , Tannous Paul , Arva Nicoleta C. , Thrush Philip T. , Monge Michael , Joong Anna , Magnetta Defne A. 
Published: March 2024

AbstractBackgroundThe relationship between histopathologic and molecular (“MMDx”®) assessments of endomyocardial biopsy (EMB) and serum donor‐derived cell‐free DNA (ddcfDNA) in acute rejection (AR) assessment following pediatric heart transplantation (HT) is unknown.MethodsEMB sent for MMDx and histopathology from November 2021 to September 2022 were reviewed. MMDx and histopathology results were compared. DdcfDNA obtained ≤1 week prior to EMB were compared with histopathology and MMDx results. The discrimination of ddcfDNA for AR was assessed using receiver‐operating curves.FindingsIn this study, 177 EMBs were obtained for histopathology and MMDx, 101 had time‐matched ddcfDNA values. MMDx and Histopathology displayed moderate agreement for T‐cell‐mediated rejection (TCMR, Kappa = 0.52, p < .001) and antibody‐mediated rejection (ABMR, Kappa = 0.41, p < .001). Discordant results occurred in 24% of cases, most often with ABMR. Compared with no AR, ddcfDNA values were elevated in cases of AR diagnosed by both histopathology and MMDx (p < .01 for all). Additionally, ddcfDNA values were elevated in injury patterns on MMDx, even when AR was not present (p = .01). DdcfDNA displayed excellent discrimination (AUC 0.83) for AR by MMDx and/or histopathology. Using a threshold of ≥0.135%, ddcfDNA had a sensitivity of 90%, specificity of 63%, PPV of 52%, and NPV of 94%.ConclusionsHistopathology and MMDx displayed moderate agreement in diagnosing AR following pediatric HT, with most discrepancies noted in the presence of ABMR. DdcfDNA is elevated with AR, with excellent discrimination and high NPV particularly when utilizing MMDx. A combination of all three tests may be necessary in some cases.
Chemsex among men who have sex with men during the Mpox health crisis in Brazil: A nationwide web survey
Authors: Santos Guilherme Reis de Santana , Ribeiro Caíque Jordan Nunes , Lima Shirley Verônica Melo Almeida , Neto João Cruz , de Sousa Anderson Reis , Bulcao Carolina da Silva , Dellagostini Pedro Gabriel , Batista Odinea Maria Amorim , de Oliveira Layze Braz , Mendes Isabel Amélia Costa , de Sousa Álvaro Francisco Lopes 
Published: March 2024

AbstractObjectiveTo understand the factors associated with the practice of chemsex among MSM in Brazil, especially during the Mpox health crisis, and to design effective prevention and intervention strategies specifically for this population.DesignA cross‐sectional and analytical study using an electronic survey, conducted from September to December 2022, during the peak of the Mpox outbreak in Brazil.SampleA total of 1452 MSM aged 18 and older.MeasurementsData were collected via the REDCap platform through a survey with 46 questions. These addressed demographic data, sexual affiliations, practices, experiences with Mpox, healthcare service usage, and stigma or fear related to Mpox.ResultsThe prevalence of chemsex was 19.42% (n = 282). Multivariate Poisson modeling indicated a high incidence of chemsex among those diagnosed with Mpox and those involved in high‐risk behaviors. The practice of chemsex was six times higher among those diagnosed with Mpox (95% CI: 4.73–9.10). MSM who engage in bugchasing had a prevalence twice that of the main outcome (95% CI: 1.31–3.16).ConclusionThere is a significant need for targeted interventions for MSM in Brazil, especially given the Mpox outbreak. This study highlights the strong relationships between chemsex, experiences with Mpox, and various sexual behaviors, underscoring the importance of effective public health initiatives.
C‐reactive protein as a novel biomarker for vitamin D deficiency in alopecia areata
Authors: AbdElneam Ahmed Ibrahim , Al‐Dhubaibi Mohammed Saleh , Bahaj Saleh Salem , Mohammed Ghada Farouk , Alantry Ahmed Kaid , Atef Lina Mohamed 
Published: March 2024

AbstractBackgroundAlopecia areata (AA) is an autoimmune condition characterized by sudden and unpredictable hair loss, with a lifetime incidence of 2%. AA can be divided into three categories: patchy alopecia, alopecia totalis, and alopecia universalis. It can affect a person's psychological health and overall quality of life. Elevated C‐reactive protein (CRP) levels in the liver may indicate an inflammatory response in autoimmune diseases. Vitamin D, essential for immune system control and skin health, may be related to AA. Hair follicles contain vitamin D receptors, which control immunological responses in the skin. However, no study has found a relationship between CRP and vitamin D in AA patients in our region.Subjects and MethodsAn analytical cross‐sectional study with a case‐control design research investigation of 82 AA patients and 81 healthy controls was carried out. Both groups’ medical histories were taken. Biochemical analysis was done for both groups as well as the serum vitamin D levels, and CRP. Genetic analysis for CDX2 rs11568820 variant detected by PCR (T‐ARMS‐PCR) method and vitamin D receptor (VDR) gene expression measured by real‐time PCR analysis for both patients and healthy subjects.ResultsCRP levels are higher in AA patients, AA patients with G/G genotypes exhibited higher concentrations of CRP when compared to those with A/A and A/G genotypes while patients with A/A genotypes have higher levels of Serum vitamin D as compared to the A/G and G/G genotypes. G allele was more abundant in AA patients. VDR gene expression was lower in AA compared to control and lower in ophiasis compared to localized and multiple patchy AA. An important inverse linear correlation was observed between vitamin D and CRP levels in ophiasis AA.ConclusionCRP concentrations were found to be elevated in AA patients. The considerable accuracy of CRP in the diagnosis of AA is substantiated by a statistically significant al. A noteworthy inverse linear association was observed between serum vitamin D and CRP concentrations in ophiasis AA.
Comparison of conjunctival pedicle flap to corneal fixation strength achieved by Tisseel® fibrin glue, ethyl cyanoacrylate adhesive, ReSure® hydrogel sealant, and conventional suturing with 8‐0 VICRYL® ophthalmic suture
Authors: VerHulst Elodie M. , Galarza Roxanne M. Rodriguez , Herring Ian P. , Ramos Renata Velloso , Kemper Andrew R. 
Published: March 2024

AbstractObjectiveTo determine and compare the fixation strength of conjunctival pedicle flaps to cornea achieved via conventional ophthalmic suture and three different adhesive compounds.Animals StudiedEx vivo porcine globes.ProceduresFollowing a 6 mm wide 500‐micron‐restricted depth lamellar keratectomy, conjunctival pedicle flaps were secured to the keratectomy site with either 8‐0 VICRYL® suture or one of three adhesive products, including Tisseel® bioadhesive, ReSure® synthetic adhesive, or ethyl cyanoacrylate adhesive (n = 10 per surgical group). Adhesive application protocol varied by product based upon adhesive biocompatibility. Corneoconjunctival tissues were then harvested, clamped in a tensile testing device, and loaded at a rate of 1 mm/s under video surveillance until the point of failure. Peak load was determined for each test and used to compare fixation strength between samples.ResultsForty conjunctival flaps were performed, with 6 omitted from evaluation due to dehiscence prior to tensile testing. Of the 34 flaps analyzed, 10 were secured with suture, 10 with cyanoacrylate, 8 with ReSure®, and 6 with Tisseel®. Flaps secured with suture withstood significantly higher applied tensile force compared with cyanoacrylate (p = .02474), ReSure® (p = .00000), and Tisseel® (p = .00002). Flaps secured with cyanoacrylate withstood significantly greater force than those secured with ReSure® and Tisseel® (p = .01194 and 0.01798, respectively). There was no significant difference in fixation strength between ReSure® and Tisseel® glue (p = .95675).ConclusionsConjunctival pedicle flap fixation using 8‐0 VICRYL® suture fixation was able to withstand significantly greater maximum tensile force compared to ReSure®, Tisseel®, or cyanoacrylate adhesives. Fixation strength achieved with cyanoacrylate adhesive was significantly greater than that achieved with ReSure® or Tisseel®.
Acoustic cavitation oxidation of ionic liquids: A brief review
Authors: Ashtaputrey Santosh D. , Agrawal Pratibha S. 
Published: March 2024

AbstractIonic liquids (ILs) are third‐generation materials with broad industrial applications. However, their toxicity, non‐biodegradability and water solubility render them persistent water pollutants. Consequently, IL degradation from water is an emerging topic of research interest nowadays. Sonolysis is one of the advanced oxidation processes (AOPs) based on ultrasound (US). During sonolysis, acoustic cavitation decomposes water into reactive hydroxyl (•OH) and hydrogen (•H) radicals, which then oxidize IL. This review discussed different AOPs for wastewater treatment reflecting their shortcomings, with a special focus on the operating conditions and effectiveness of US‐based hybrid AOPs for IL degradation. The synergistic effects of US over other AOPs are investigated. Hybid‐sonolysis has proven to significantly enhance IL mineralization in shorter reaction time by generating more reactive‐free radicals in an aqueous medium at experimentally optimized conditions. Finally, this review identifies research gap and proposes future directions of IL degradation. It will serve as a valuable resource for future studies of IL degradation using US techniques.
INFLUENCE OF ANATASE TITANIUM DIOXIDE NANOTUBE ARRAYS ON HUMIDITY SENSOR SYNTHESIZED BY ELECTROCHEMICAL ANODIZATION
Authors: Ahmed Azhar Najwa Ezira , Mohammad Jafar Salifairus , Sulimai Nurul Hidah , Malek Mohamad Firdaus , Mamat Mohamad Hafiz , Shariffudin Shafinaz Sobihana , Mohammad Maryam , Eswar Kevin Alvin , Abu Bakar Ahmad Shuhaimi , A. H. Alrokayan Salman , A. Khan Haseeb , Rusop M. 
Published: March 2024

Humidity sensors have become increasingly important and widely used to improve the quality of life and industrial processes. Over the past decades, titanium dioxide (TiO2) has received wide attention in many promising areas such as sensors, solar cells, and photocatalytic. However, TiO2 required high operating conditions such as high temperatures to examine the crystalline stability phase. This study focuses on highly ordered titanium dioxide nanotube arrays (TiO2 NTAs) film synthesized using the electrochemical anodization method. Annealing temperature effect on the fabricated TiO2 NTAs was investigated. An electrolyte solution was prepared by mixing ammonium fluoride (0.3 wt%) and ethylene glycol (25 ml) with deionized water (2 vol%). Titanium (Ti) sheet was anodized at 35 V for 120 minutes. The films were annealed from 350 °C to 550 °C. FESEM images showed the diameter size of TiO2 NTAs film decreases as the annealing temperatures increases. Results had also shown that the average diameter annealed at 450 °C was around ~50.82 nm while the XRD pattern demonstrated TiO2 NTAs exhibiting an anatase phase with a prominent (101) peak recorded for the sample prepared at 450 °C with a high crystallite size of 29.17 nm. The calculated optical band gap annealed at 450 °C (3.24 eV) is comparable with other literature. The current-voltage characteristic of TiO2 NTAs film reported a high current for 450 °C (1.12 x 10-5 A) with a conductivity of 0.048 S.cm-1 and high sensitivity (287.72).
GRAVIMETRIC AND ELECTROCHEMICAL TEST OF ETLINGERA ELATIOR INFLORESCENCE EXTRACT AS GREEN CORROSION INHIBITOR
Authors: Rosli Syahidah Nabila , Kamil Othman Norinsan 
Published: March 2024

At present, organic corrosion inhibitors which are commonly used such as silicate and phosphate have a high level of toxicity. It has prompted the search for green corrosion inhibitors because of its eco-friendly properties and has a lower level of toxicity. Therefore, this study has been conducted to investigate the inhibition efficiency (IE%) and corrosion rate of mild steel in 0.5 M HCl acidic medium. The data obtained through weight loss and the electrochemical method at various concentrations and temperatures. The surface morphologies was observed using Scanning Electron Microscope (SEM). Different experimental conditions were also used such as electrochemical impedance spectroscopy (EIS) and potentiodynamic polarization curves (PPC). EIS findings revealed that the addition of studied inhibitors prevented the degradation of mild steel in HCl solution, hence leading to a high value of polarization resistance compared to the blank solution. Besides that, the PPC results suggested that the tested samples had a mixed-type effect which decreased the anodic and cathodic corrosion reactions. Surface characterization by SEM illustrated a notable decrease in surface roughness of mild steel after the addition of inhibitors. Outcomes from the present study indicates that the Etlingera Elatior inflorescence extract acts as a good corrosion inhibitor for mild steel sample in HCl solution with IE% value above 93.63 %. Formation of the protective layer becomes weaker as the temperature raises.
Permeability Data Treatment from Analogous Outcrop for Use in Three-Dimensional Reservoir Model
Authors: Albuquerque Camila Faria de , Silva Aline Theophilo , Mello Claudio Limeira 
Published: March 2024

Over the past forty years, the study of analogous outcrops has become a common practice in the petroleum industry to access more comprehensive geological datasets and better parameterize various geological features. As most reservoirs do not outcrop and all the data obtained are restricted to those collected from wells located in areas of major interest or from indirect measurements, the study of analogous outcrops has brought important contributions to improve the production routines and still represents a helpful information resource. The use of data from analogous outcrops permits, for example, to estimate the sedimentary facies distribution in true reservoirs, and thus to improve on the reliability of fluid flow modeling during the oil field exploration. However, such data must be processed to become equivalent to the data collected under the reservoir conditions and the results obtained to be more realistic. This work presents the statistical method used to make permeability data obtained from an outcrop compatible with the subsurface conditions of poorly consolidated and tectonically deformed sandstone reservoirs. The studied outcrop is predominantly composed of Eocene fluvial sandstones (Resende Formation) of the Volta Redonda Basin, located in the Central Segment of the Continental Rift of Southeastern Brazil. These deposits are affected by deformation bands and faults. From statistical analysis, it was intended that the permeability data become more suitable to be used, in the next phase of the studies, to build a 3D flow model, in which it will be possible to test the potential of different tectonic structures acting as hydraulic barriers in poorly consolidated and deformed reservoirs. The methodological approach applied in this study made it possible to turn compatible the permeability data obtained in conditions of no confining pressures from the outcrop with reservoir conditions under confinement pressures of 2,000 psi. Such pressure conditions are frequently observed in important Maastrichtian reservoirs found in the Brazilian Southeastern Margin.
The Dad and the Lad: Who Is My Client?
Authors: Whitfield Scott , Wadsworth Nick , Butt Joanne 
Published: March 2024

This article discusses an applied case study with a young footballer and his father. Contacted initially to offer psychological support to the athlete, after conducting his needs analysis, the practitioner was left questioning who his client really was. This paper outlines how the practitioner arrived at the decision to work with the father rather than the athlete, before reflecting on how his own experience as a young athlete fueled his commitment to work with this case. Drawing upon acceptance and commitment therapy, the intervention’s aim was to increase the father’s psychological flexibility and explore ways he could better support his son. The evaluation suggested that working alongside the practitioner helped the father (a) gain clarity with regard to what was important to him as a parent and (b) begin to behave in a manner that was more aligned to his son’s needs. By virtue of the changes he observed in his father, the young athlete also discussed the implications this had for his own mindset and performance.
Lower-Extremity Visuomotor Reaction Time Is Not Different Between Males and Females Following Anterior Cruciate Ligament Reconstruction
Authors: Genoese Francesca M. , Walaszek Michelle C. , Collins Katherine , Reiche Elaine , Triplett Ashley , Harkey Matthew S. , Kuenze Christopher , Baez Shelby E. 
Published: March 2024

Visuomotor reaction time (VMRT) is predictive of lower-extremity musculoskeletal injury and may be a modifiable anterior cruciate ligament (ACL) injury risk factor that affects the incidence of primary and secondary ACL injuries in females. However, it is unknown if females with ACL reconstruction (ACLR) experience diminished VMRT compared with their male counterparts. The purpose of this study was to compare lower-extremity VMRT (LEVMRT) between males and females with ACLR. Female (n = 40) and male (n = 20) participants who were between 4 and 12 months after primary, unilateral ACLR completed a LEVMRT task with each limb using a series of wireless light discs. Mann–Whitney U tests were used to compare between-group differences for LEVMRT (in milliseconds). No statistically significant sex differences were observed for LEVMRT when the ACLR limb deactivated the light discs (females = 509.5 [132.5], males = 507.0 [79.8]; p = .77) or when the ACLR limb was stabilizing while the nonsurgical limb deactivated the light discs (females = 528.5 [105.3], males = 546.0 [92.5]; p = .77). Both males and females may benefit from visual motor training to improve VMRT after ACLR.
Epitope(s) involving amino acids of the fusion loop of Japanese encephalitis virus envelope protein is(are) important to elicit protective immunity
Authors: Fan Yi-Chin , Chen Jo-Mei , Chen Yi-Ying , Ke Yuan-Dun , Chang Gwong-Jen J. , Chiou Shyan-Song 
Published: March 2024

ABSTRACT

Dengue vaccine candidates have been shown to improve vaccine safety and efficacy by altering the residues or accessibility of the fusion loop on the virus envelope protein domain II (DII
FL
) in an
ex vivo
animal study. The current study aimed to comprehensively investigate the impact of DII
FL
mutations on the antigenicity, immunogenicity, and protective efficacy of Japanese encephalitis virus (JEV) virus-like particles (VLPs) in mice. We found the DII
FL
G106K/L107D (KD) and W101G/G106K/L107D (GKD) mutations altered the binding activity of JEV VLP to cross-reactive monoclonal antibodies but had no effect on their ability to elicit total IgG antibodies in mice. However, JEV VLPs with KD or GKD mutations induced significantly less neutralizing antibodies against JEV. Only 46% and 31% of the KD and GKD VLPs-immunized mice survived compared to 100% of the wild-type (WT) VLP-immunized mice after a lethal JEV challenge. In passive protection experiments, naïve mice that received sera from WT VLP-immunized mice exhibited a significantly higher survival rate of 46.7% compared to those receiving sera from KD VLP- and GKD VLP-immunized mice (6.7% and 0%, respectively). This study demonstrated that JEV DII
FL
is crucial for eliciting potently neutralizing antibodies and protective immunity against JEV.

IMPORTANCE
Introduction of mutations into the fusion loop is one potential strategy for generating safe dengue and Zika vaccines by reducing the risk of severe dengue following subsequent infections, and for constructing live-attenuated vaccine candidates against newly emerging Japanese encephalitis virus (JEV) or Japanese encephalitis (JE) serocomplex virus. The monoclonal antibody studies indicated the fusion loop of JE serocomplex viruses primarily comprised non-neutralizing epitopes. However, the present study demonstrates that the JEV fusion loop plays a critical role in eliciting protective immunity in mice. Modifications to the fusion loop of JE serocomplex viruses might negatively affect vaccine efficacy compared to dengue and zika serocomplex viruses. Further studies are required to assess the impact of mutant fusion loop encoded by commonly used JEV vaccine strains on vaccine efficacy or safety after subsequent dengue virus infection.