bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mathematical Models of the Effect of Glucagon on Glycemia in Individuals With Type 2 Diabetes Treated With Dapagliflozin
Authors: Yamada Tomoko , Sugimoto Hikaru , Hironaka Ken-ichi , Morita Yasuko , Miura Hiroshi , Otowa-Suematsu Natsu , Okada Yuko , Hirota Yushi , Sakaguchi Kazuhiko , Kuroda Shinya , Ogawa Wataru 
Published: April 2024

Abstract

Context
Sodium-glucose cotransporter 2 (SGLT2) inhibitors lower blood glucose levels by promoting urinary glucose excretion, but their overall effects on hormonal and metabolic status remain unclear.

Objective
We here investigated the roles of insulin and glucagon in the regulation of glycemia in individuals treated with an SGLT2 inhibitor using mathematical model analysis.

Methods
Hyperinsulinemic-euglycemic clamp and oral glucose tolerance tests were performed in 68 individuals with type 2 diabetes treated with the SGLT2 inhibitor dapagliflozin. Data previously obtained from such tests in 120 subjects with various levels of glucose tolerance and not treated with an SGLT2 inhibitor were examined as a control. Mathematical models of the feedback loops connecting glucose and insulin (GI model) or glucose, insulin, and glucagon (GIG model) were generated.

Results
Analysis with the GI model revealed that the disposition index/clearance, which is defined as the product of insulin sensitivity and insulin secretion divided by the square of insulin clearance and represents the glucose-handling ability of insulin, was significantly correlated with glycemia in subjects not taking an SGLT2 inhibitor but not in those taking dapagliflozin. Analysis with the GIG model revealed that a metric defined as the product of glucagon sensitivity and glucagon secretion divided by glucagon clearance (designated production index/clearance) was significantly correlated with blood glucose level in subjects treated with dapagliflozin.

Conclusion
Treatment with an SGLT2 inhibitor alters the relation between insulin effect and blood glucose concentration, and glucagon effect may account for variation in glycemia among individuals treated with such drugs.
Preoperative Performance Status Threshold for Favorable Surgical Outcome in Metastatic Spine Disease
Authors: Lenschow Moritz , Lenz Maximilian , Telentschak Sergej , von Spreckelsen Niklas , Sircar Krishnan , Oikonomidis Stavros , Kernich Nikolaus , Walter Sebastian G. , Knöll Peter , Perrech Moritz , Goldbrunner Roland , Eysel Peer , Neuschmelting Volker 
Published: April 2024

BACKGROUND AND OBJECTIVES:
Surgical treatment is an integral component of multimodality management of metastatic spine disease but must be balanced against the risk of surgery-related morbidity and mortality, making tailored surgical counseling a clinical challenge. The aim of this study was to investigate the potential predictive value of the preoperative performance status for surgical outcome in patients with spinal metastases.

METHODS:
Performance status was determined using the Karnofsky Performance Scale (KPS), and surgical outcome was classified as “favorable” or “unfavorable” based on postoperative changes in neurological function and perioperative complications. The correlation between preoperative performance status and surgical outcome was assessed to determine a KPS-related performance threshold.

RESULTS:
A total of 463 patients were included. The mean age was 63 years (range: 22-87), and the mean preoperative KPS was 70 (range: 30-100). Analysis of clinical outcome in relation to the preoperative performance status revealed a KPS threshold between 40% and 50% with a relative risk of an unfavorable outcome of 65.7% in KPS ≤40% compared with the relative chance for a favorable outcome of 77.1% in KPS ≥50%. Accordingly, we found significantly higher rates of preserved or restored ambulatory function in KPS ≥50% (85.7%) than in KPS ≤40% (48.6%; P < .001) as opposed to a significantly higher risk of perioperative mortality in KPS ≤40% (11.4%) than in KPS ≥50% (2.1%, P = .012).

CONCLUSION:
Our results underline the predictive value of the KPS in metastatic spine patients for counseling and decision-making. The study suggests an overall clinical benefit of surgical treatment of spinal metastases in patients with a preoperative KPS score ≥50%, while a high risk of unfavorable outcome outweighing the potential clinical benefit from surgery is encountered in patients with a KPS score ≤40%.
Conservation energetics of beluga whales: using resting and swimming metabolism to understand threats to an endangered population
Authors: John Jason S. , Christen Dennis R. , Flammer Katherine L. , Kendall Traci L. , Nazario Emily C. , Richter Beau P. , Gill Verena , Williams Terrie M. 
Published: April 2024

ABSTRACT
The balance between energetic costs and acquisition in free-ranging species is essential for survival, and provides important insights regarding the physiological impact of anthropogenic disturbances on wild animals. For marine mammals such as beluga whales (Delphinapterus leucas), the first step in modeling this bioenergetic balance requires an examination of resting and active metabolic demands. Here, we used open-flow respirometry to measure oxygen consumption during surface rest and submerged swimming by trained beluga whales, and compared these measurements with those of a commonly studied odontocete, the Atlantic bottlenose dolphin (Tursiops truncatus). Both resting metabolic rate (3012±126.0 kJ h−1) and total cost of transport (1.4±0.1 J kg−1 m−1) of beluga whales were consistent with predicted values for moderately sized marine mammals in temperate to cold-water environments, including dolphins measured in the present study. By coupling the rate of oxygen consumption during submerged swimming with locomotor metrics from animal-borne accelerometer tags, we developed predictive relationships for assessing energetic costs from swim speed, stroke rate and partial dynamic acceleration. Combining these energetic data with calculated aerobic dive limits for beluga whales (8.8 min), we found that high-speed responses to disturbance markedly reduce the whale's capacity for prolonged submergence, pushing the cetaceans to costly anaerobic performances that require prolonged recovery periods. Together, these species-specific energetic measurements for beluga whales provide two important metrics, gait-related locomotor costs and aerobic capacity limits, for identifying relative levels of physiological vulnerability to anthropogenic disturbances that have become increasingly pervasive in their Arctic habitats.
The Continuous Time-Resource Trade-off Scheduling Problem with Time Windows
Authors: Artigues Christian , Hébrard Emmanuel , Quilliot Alain , Toussaint Hélène 
Published: April 2024

We introduce a variant of the cumulative scheduling problem (CuSP) characterized by continuous modes, time windows, and a criterion that involves safety margin maximization. The study of this variant is motivated by the Geospatial based Environment for Optimisation Systems Addressing Fire Emergencies Horizon 2020 Project, which is devoted to the design of evacuation plans in the face of natural disasters and more specifically, wildfire. People and goods have to be transferred from endangered places to safe places, and evacuation planning consists of scheduling evacuee moves along precomputed paths under arc capacities and deadlines. The resulting model is relevant in other contexts, such as project or industrial process scheduling. We consider here several formulations of the continuous time-resource trade-off scheduling problem (CTRTP-TW) with a safety maximization objective. We establish a complete complexity characterization distinguishing polynomial and NP-hard special cases depending on key parameters. We show that the problem with fixed sequencing (i.e., with predetermined overlap or precedence relations between activities) is convex. We then show that the preemptive variant is polynomial, and we propose lower and upper bounds based on this relaxation. A flow-based mixed-integer linear programming formulation is presented, from which a branch-and-cut exact method and an insertion heuristic are derived. An exact dedicated branch-and-bound algorithm is also designed. Extensive computational experiments are carried out to compare the different approaches on evacuation planning instances and on general CTRTP-TW instances. The experiments also show the interest of the continuous model compared with a previously proposed discrete approximation. History: Accepted by Andrea Lodi, Area Editor for Design & Analysis of Algorithms—Discrete. Funding: This work was funded by the Horizon 2020 Marie Skłodowska-Curie Research and Innovation Staff Exchange European Project 691161 GEO-SAFE (Geospatial based Environment for Optimisation Systems Addressing Fire Emergencie). This work has also been supported by ANITI, the Artificial and Natural Intelligence Toulouse Institute. Supplemental Material: The software that supports the findings of this study is available within the paper and its Supplemental Information ( https://pubsonline.informs.org/doi/suppl/10.1287/ijoc.2022.0142 ) as well as from the IJOC GitHub software repository ( https://github.com/INFORMSJoC/2022.0142 ). The complete IJOC Software and Data Repository is available at https://informsjoc.github.io/ .
Cryogenic focus measurement system for a wide-field infrared space telescope
Authors: Condon Samuel S. , Padin Stephen , Bock James , Hui Howard , Korngut Phillip , Nguyen Chi , Ostby Jordan 
Published: April 2024

We describe a technique for measuring focus errors in a cryogenic,
wide-field, near-infrared space telescope. The measurements are made
with a collimator looking through a large vacuum window, with a
reflective cold filter to reduce the background thermal infrared
loading on the detectors and optics. The vacuum window and cold filter
introduce a wavefront error that we characterize using an
autocollimating microscope. For the 200 mm diameter aperture f/3 space telescope SPHEREx, we achieve a
focus position measurement with a ∼15µm systematic and a ∼5µm statistical error.
Associations of Intrapancreatic Fat Deposition With Incident Diseases of the Exocrine and Endocrine Pancreas: A UK Biobank Prospective Cohort Study
Authors: Dong Xiaowu , Zhu Qingtian , Yuan Chenchen , Wang Yaodong , Ma Xiaojie , Shi Xiaolei , Chen Weiwei , Dong Zhao , Chen Lin , Shen Qinhao , Xu Hongwei , Ding Yanbing , Gong Weijuan , Xiao Weiming , Wang Shengfeng , Li Weiqin , Lu Guotao 
Published: April 2024

INTRODUCTION:
To investigate whether increased intrapancreatic fat deposition (IPFD) heightens the risk of diseases of the exocrine and endocrine pancreas.

METHODS:
A prospective cohort study was conducted using data from the UK Biobank. IPFD was quantified using MRI and a deep learning–based framework called nnUNet. The prevalence of fatty change of the pancreas (FP) was determined using sex- and age-specific thresholds. Associations between IPFD and pancreatic diseases were assessed with multivariate Cox-proportional hazard model adjusted for age, sex, ethnicity, body mass index, smoking and drinking status, central obesity, hypertension, dyslipidemia, liver fat content, and spleen fat content.

RESULTS:
Of the 42,599 participants included in the analysis, the prevalence of FP was 17.86%. Elevated IPFD levels were associated with an increased risk of acute pancreatitis (hazard ratio [HR] per 1 quintile change 1.513, 95% confidence interval [CI] 1.179–1.941), pancreatic cancer (HR per 1 quintile change 1.365, 95% CI 1.058–1.762) and diabetes mellitus (HR per 1 quintile change 1.221, 95% CI 1.132–1.318). FP was also associated with a higher risk of acute pancreatitis (HR 3.982, 95% CI 2.192–7.234), pancreatic cancer (HR 1.976, 95% CI 1.054–3.704), and diabetes mellitus (HR 1.337, 95% CI 1.122–1.593, P = 0.001).

DISCUSSION:
FP is a common pancreatic disorder. Fat in the pancreas is an independent risk factor for diseases of both the exocrine pancreas and endocrine pancreas.
Petri net based diagnostic approach for concurrent discrete event systems
Authors: Windmann Stefan 
Published: April 2024

Abstract
This paper introduces a new diagnostic approach for concurrent discrete event systems (DES) in automated production plants. The proposed diagnostic procedure is based on Petri net models of the DES. Discrepancies between the Petri net models and event sequences, which are observed during the operation of the production plant, are detected as potential faults. A case-based diagnosis is then carried out to identify fault types that are easy to interpret for humans. The proposed diagnostic procedure is evaluated using an industrial conveying system.
Lack-of-fit reduction in non-equilibrium thermodynamics applied to the Kac–Zwanzig model
Authors: Mladá Kateřina , Šípka Martin , Pavelka Michal 
Published: April 2024

Abstract
Even when microscopic particle dynamics is purely mechanistic and thus reversible, the behavior of macroscopic systems composed of those particles is irreversible. In other words, effectively irreversible behavior emerges out of purely reversible dynamics when we do not observe all degrees of freedom of the detailed dynamics. But how can we find the irreversible macroscopic evolution equations when we only know the reversible microscopic equations? Using the so-called lack-of-fit reduction, which gives the reduced evolution as a sum of Hamiltonian and gradient dynamics, we reduce the purely Hamiltonian Kac–Zwanzig model to a set of irreversible evolution equations with no fitting parameters.
Bioinorganic metal nanoparticles and their potential applications as antimicrobial, antioxidant and catalytic agents: a review
Authors: Naseem Khalida , Aziz Asad , Khan Mohammad Ehtisham , Ali Shahzaib , Khalid Awais 
Published: April 2024

Abstract
This review article covers the biogenic synthesis of metal nanoparticles (MNPs) having definite shape and size while using extract obtained from different biological sources such as bacteria, fungi, algae and plants. These biological materials are composed of chloroplast, thylakoid, different types of enzymes extracted from different biogenic sources, different phytochemicals such as phenols, flavonoids, and citric acid having functional groups such as sulfate, carboxyl, amino, amide and hydroxyl groups. These functional groups and enzymes act as efficient reductants to convert metal ions into metal atoms and alternatively metal atoms combine to form MNPs while long hydrocarbon chains present in these bio-macromolecules act as cage to stabilize them for prolong time. Effect of nature of source extract, different reaction conditions such as extract amount, salt amount and solvent used during MNPs preparation process have been critically discussed here in detail. Use of synthesized bioinorganic NPs in various areas including their effectiveness in fighting against bacteria, viruses, fungi, cancer, inflammation, and their potential role in catalytic reduction of environmental harmful substances into friendly products has also been described in a clear and concise manner along with their future consideration.
The Business of Virtues: The Theological Virtues in the Moral Conception of Commercial Organizations
Authors: Kuo Henry S. 
Published: April 2024

In her 2006 book, The Bourgeois Virtues, economist and philosopher Deirdre McCloskey argued that what fundamentally drives economic development and growth is not so much government intervention or unrestricted libertinism but a set of “bourgeois virtues” that celebrates classical liberalism while powering the innovation that gave rise to modern economies. Drawing on the seven virtues proposed by St. Thomas Aquinas, McCloskey discusses the ways in which each virtue interfaced with the other six and their critical roles in the history of economic development. This article builds on her insights by making two moves. McCloskey, a skeptic of neo-institutional philosophies, does not consider significantly virtue’s application to commercial organizations. I argue, however, that these ideas do matter to the organization and operation of businesses and similar institutions. In fact, I suggest that the ideology and ethics of institutions function as part of a dialectical conversation between the institutional “ontology” that forms the moral character of its members and those members, who, in turn, (re)form the institution’s ethics. Second, if institutions can embody virtues, how the cardinal virtues—prudentia, temperantia, fortitudo, and iustitia—figure institutionally is not difficult. More challenging is how the theological virtues—love, faith, and hope—which seem to apply to individuals, can apply. Thus, this article argues for how these virtues can be embodied in business organizations, concluding that such a framework allows for a “trinitarian” understanding of the economy as a perichoretic dynamic between the consumer, business organizations, and political/legal structures. In doing so, it criticizes and provides a way out of prevailing political dynamics that often pit individual freedom against institutions.
Open Notes Experiences of Parents in the Pediatric ICU
Authors: Chu Selby , Sisk Bryan A. , Kolmar Amanda , Malone Jay R. 
Published: April 2024

OBJECTIVE
We examined how parents experience and navigate open access to clinical notes (“open notes”) in their child’s electronic health record and explored their interactions with clinicians during an ICU admission.

METHODS
We performed a qualitative analysis using semistructured interviews of English-speaking parents who accessed their child’s clinical notes during a pediatric ICU (general or cardiac) admission. We included patient-parent dyads with an ICU admission ≥48 hours between April 2021 and December 2022, note access by proxy timestamp during the ICU course, and either patient age &lt;12 years or incapacitated adolescent ages 12 to 21 years. Purposive sampling was based on sociodemographic and clinical characteristics. Phone interviews were audio-recorded, transcribed, and analyzed using inductive thematic codebook analysis.

RESULTS
We interviewed 20 parents and identified 2 thematic categories, outcomes and interactions, in parents accessing clinical notes. Themes of outcomes included applied benefits, psychosocial and emotional value, and negative consequences. Themes of interactions included practical limitations and parental approach and appraisal. The ICU context and power dynamics were a meta-theme, influencing multiple themes. All parents reported positive qualities of note access despite negative consequences related to content, language, burdens, and lack of support. Parents suggested practice and design improvements surrounding open note access.

CONCLUSIONS
Parental experiences with open notes reveal new, unaddressed considerations for documentation access, practices, and purpose. Parents leverage open notes by negotiating between the power dynamics in the ICU and the uncertain boundaries of their role and authority in the electronic health record.
Methodology for high-performance liquid chromatography detection of latanoprost and latanoprost free acid
Authors: Jankowski Ashleigh M. , Vardar Camila , Talarico Matthew V. , Wuchte Liana , Byrne Mark E. 
Published: April 2024

AbstractA gradient high-performance liquid chromatography (HPLC) method has been developed to determine the concentrations of latanoprost (LP) and latanoprost free acid (LPA) in aqueous solutions. It is novel due to a combination of its simplicity, speed, and detection capability in aqueous solutions for both active drug (LPA) and prodrug (LP). This method is applicable for the research and development of novel drug delivery devices and quality control assays for experimental and commercial laboratory settings, as it allows for a high sample throughput. Samples were chromatographed across a C18 + 2.7 µm 4.6 × 7.5 mm reversed-phase column with gradient elution using a mobile phase of aqueous acetic acid (pH 3.1) and acetonitrile with 0.1% acetic acid. UV spectrophotometry was used to monitor the eluents at 210 nm. Drug concentrations from 1.0 to 150 μg mL−1 were tested, with good linearity observed across the range. LPA had a signature peak at approximately 4.82 min (SD < 0.08) and LP at 9.27 min (SD < 0.07). For both drug and pro-drug, LOD and LOQ were 1.0 and 2.5 μg mL−1, respectively. This assay which accurately measures both prodrug and drug in a single injection, has significant applicability in determining the release kinetics of novel LP drug delivery systems.
Inhibition of cocoa peel (theobroma cacao l.) extract gel on growth of staphylococcus aureus
Authors: Rahayu Yani C. , Prihanti Ayu M. , Salsabila Tania P. 
Published: April 2024

Objective: The aim of this study was examined the inhibition of cocoa peel (Theobroma cacao L.) ethanol extract gel against the growth of Staphylococcus aureus. One of antimicrobial agents that is frequently used for treatment of S.aureus infection is chlorhexidine. Prolonged use of chlorhexidine can cause side effects, such as discoloration of teeth, restorations and tongue, and also desquamative lesions of oral mucosa. Therefore, to minimize the side effects of synthetic antimicrobial agents, an alternative antimicrobial therapy is needed, such as topical antimicrobials derived from natural ingredients like cocoa peel.
Material and Methods: This study was an in vitro laboratory experimental study with a post test only control groupdesign. Identified cocoa peel were extracted using ultrasonic method with ethanol 70% then formulated into gel with dosage of 20 mg/ml, 40 mg/ml, 80 mg/ml, 160 mg/ml, and 320 mg/ml, then tested using disk diffusion method and compared with positive control, chlorhexidine gel and negative control, gelling base.
Result: Inhibition zone was formed in group of cocoa peel ethanol extract gel with dosage of 80 mg/ml, 160 mg/ml, and 320 mg/ml, which indicated that there was inhibition activity against Staphylococcus aureus. The results of statistical tests showed that there were significant differences between sample groups.
Conclusion: ethanol extract gel of cocoa peel (Theobroma cacao L.) can inhibit the growth of Staphylococcus aureus with dosage of 80 mg/ml, 160 mg/ml, and 320 mg/ml.
Effect of 10% kepok banana peel extract gel (musa paradisiaca linn. kepok) application on periodontal regeneration process in periodontal healing of wistar rat (rattus norvegicus): In vivo study
Authors: Suryono  , Sari Rezmelia , Wulandari Felia R. , Andini Hefy , Widjaja Jeanette , Nugraheni Trisna D. 
Published: April 2024

Objective: The aim of our study was to determine the effect of application of 10% Kepok banana peel extract gel (Musa paradisiaca linn. Kepok) on periodontal regeneration process in periodontal healing of wistar rat (Rattus norvegicus).
Methods: Fourty-eight wistar rats were divided into 3 groups, namey 16 rats as the positive control group (Aloclair gel), 16 rats as the negative control group (CMC-Na gel 2%) and 16 rats as the treatment group (10% Kepok banana peel extract gel). The induction of periodontitis was performed using modified ligation technique for 7 days with additional injection of Aggregatibacter actinomycetemcomitans bacteria on the first day. Wistar rats were euthanized on days 1, 3, 5, 7, 14 for histological analysis to evaluate the number of macrophages, lymphocytes, osteoclasts, osteoblasts and fibroblasts. Radiographs were taken on day 21 using digital periapical radiograph (PaloDex Oy). Data were analyzed using Two-Way ANOVA and Post Hoc LSD tests.
Results: Data analysis showed a significant difference in the cell numbers among the groups. A decreasing number of lymphocytes, macrophages, and osteoclasts could already be observed since the 1st day, so could an increasing number of fibroblasts and osteoblasts. The fibroblasts and osteoblasts of the treatment group already reached their peak on the 5th day, faster than the negative control and positive control groups that reached their peaks on the 7th day.
Conclusion: The application of 10% Kepok banana peel extract gel (Musa paradisiaca linn. Kepok) caused significant acceleration of periodontal regeneration process in periodontal healing of wistar rat (Rattus norvegicus).