bluuebunny/crossref_metadata_2025_split huggingface dataset:
10 A multi‐component model can predict outcome of restrictive surgery for obesity at baseline and 3 months
Authors: ASLAM N , RASHED H , MADAN AK , TICHANSKY DS , CUTTS T , JOHNSON WD , ABELL TL 
Published: May 2006

Introduction:  We previously reported that a multi‐component model of autonomic and enteric factors may correlate with ultimate weight loss or gain after restrictive obesity surgery (NGM 2005; 17:472).Patients:  We report on 39 patients, 4 male, 35 female, mean age 37.2 years, followed for up to 16 years post‐operatively after vertical banded gastroplasty.Methods:  Two autonomic measures (adrenergic: PAR and VC and cholinergic: RRI) and one enteric measure (electrogastrogram: EGG) were recorded at baseline as previously described (DDS 44: 74s–78s, 1999). We performed a discriminant function analysis to investigate whether a patient's EGG, PAR, RRI, and VC values could be used to classify that patient as a loser or gainer following weight control surgery. The patients were divided into two categories (10 gainers, 29 losers), depending on the latest weight compared to baseline; discriminant criterion derived from the patient's data was applied to each patient's autonomic and enteric values to determine whether these measurements separated the patients into their true weight category.Results:  A discriminate model based on baseline measures successfully predicted ultimate weight gain in 8/10 (80%) of patients who subsequently gained weight and weight loss in 24/29 (83%) of patients who in subsequently lost weight for a total correct classification rate of 32/39 (82%). The same model with data at 3 months post‐operatively predicted weight gain in 9 of 10 (90%) of patients and weight loss in 24 of 29 (83%) of patients, for a total correct classification rate of 34/39 pts (87%) (See table).Conclusions:  A multi‐component model demonstrates that baseline and 3 months post‐operative measures can predict ultimate weight outcome from restrictive obesity surgery.

Time
Predicted Baseline
Outcome Lose
Total
3 Month Predicted
Outcome Lose
Total

Result
Gain
Lose
Total
Gain
Lose
Total

Gain
8 (80%)
2
10
9 (90%)
1
10

Lose
5
24 (83%)
29
5
24 (83%)
29
22 Comparison of multichannel electrogastrograms obtained with the use of three different electrode types
Authors: JONDERKO K , OBROK I , KRUSIEC‐SWIDERGOL B , KASICKA‐JONDERKO A , BLONSKA‐FAJFROWSKA B 
Published: May 2006

Background/Aims:  Multichannel recording of the gastric myoelectrical activity (GMA) is a promising evolution of electrogastrography. In the study we searched for electrodes the most suitable to obtain high quality multi‐channel electrogastrograms.Methods:  Twelve young volunteers (9 F, 3 M, aged 24.3 ± 0.6 years) underwent on separate days three four‐channel electrogastrographic recordings of the GMA: 30 min fasted and 90 min after a solid meal stimulation. The electrogastrograms were recorded in randomized order with 3M Red Dot class Ag/AgCl electrodes designed primarily for long‐term electrocardiographic monitoring: type­2222 (conductive area, CA/total area, TA): 2.00/10.24 cm2, type­2271 2.54/29.64 cm2, type­2660 11.64/11.64 cm2 (total surface conductive!) and subsequently analysed with Polygram Net™ EGG 311224 software (Medtronic, USA). Electrical resistance between active electrodes relative to the reference one was measured with a digital ohmmeter before and after the recording session.Results:  Type­2660 yielded consistently higher electrical resistance than the other electrode types, moreover in the case of type­2271 and type­2660 electrical conductivity significantly improved at the end of the recording relative to the basal measurement. Analysis of variance involving the relative time‐share of normogastria, meal‐induced change in dominant power, as well as a set of parameters unique for the multichannel electrogastrography and intended to characterize the so‐called spatial displacement of the gastric slow waves did not reveal any statistically significant effect of the electrode type on the parameters of the multichannel electrogastrogram. Although, when particular numerical data were inspected, type­2271 was found to perform slightly worse than the other electrode types. Type­2271 was also rated the less handy among the electrodes tested.Conclusion:  Multichannel surface electrogastrography seems to be technically feasible with any type of high quality Ag/AgCl electrodes available on the market, whereas small dimensions enabling easy placement on the abdomen may be a feature favouring the choice of a particular electrode type for this examination.
24 Electrogastrography EGG in pancreas diabetes
Authors: SCHAFER E , RUSZNYAK K , SCHWAB R , GYOKERES T , FODOR Gy , PAP A 
Published: May 2006

Background:  Timing and criteria of testing for gastric dysmotility in pancreatic diabetes is not well established.Aim:  To investigate the pattern of EGG and autonomic neuropathy (AN) in patients with pancreas diabetes mellitus to clarify the relationship between autonomic neuropathy, alcohol consumption, glucose homeostasis, diabetes duration, and EGG.Patients and methods:  Thirty patients with pancreas diabetes mellitus were enrolled into the study. Mean duration of diabetes mellitus was 11 (0–25) years, mean blood glucose levels: 8.13 ± 2.7 mmoll−1, HbA1c 8.3 ± 2.96%; 25/30 patients were treated with insulin, the others were on rigorous diet, all of them received high dose pancreatin substitution therapy. Ten matched controls without diabetes and pancreatic insufficiency were also examined. AN was evaluated by the cardiovascular reflex tests according to the Ewing's criteria (Diab. Care 8 (5): 491–497, 1985.), EGG was monitored for 30–30 min in both fasting and in postprandial states, using a Digitrapper EGG (Synectic Med., Stockholm). EGG rhythm disturbances (bradygastria: 0–2 cpm, tachygastria: 4–10 cpm) and meal evoked EGG signal amplitude (power) changes were determined.Results:  9/30 pts had mild to moderate parasympathetic AN, 1/30 pts had sympathetic AN, 5/30 pts had both parasympathetic and sympathetic AN; 17/30 pts demonstrated myoelectric abnormalities: 5/30 pts had predominant bradygastria, 3/30 tachygastria, and in other 9/30 pts only an absence of increase in the postprandial signal amplitude was found. Overall, 7/30 pts with abnormal EGG did not demonstrated AN. Abnormal EGG showed no correlation with actual blood sugar values or HbA1c, but it was associated with diabetes duration more than 10 years.Conclusion:  Our results suggest that beside neuropathy other factors such as alcohol toxicity, sympathetic and parasympathetic imbalance or long‐term inappropriate glucose metabolism may be involved in the gastric myoelectric abnormalities provoked by pancreas diabetes.
26 Protein and ginger for the treatment of chemotherapy‐induced delayed nausea and gastric dysrhythmia
Authors: LEVINE ME , GILLIS M , YANCHIS S , VOSS AC , STERN RM , KOCH KL 
Published: May 2006

Background:  Delayed nausea occurs in many cancer patients during the three days following administration of a cytotoxic agent. Meals high in protein content decrease the nausea of motion sickness and pregnancy, possibly by enhancing normal gastric myoelectrical activity and/or by reducing gastric dysrhythmias. Ginger may also have anti‐nausea properties. The aim of this study was to explore the use of a nutritional intervention consisting of high protein meals and ginger for the management of delayed nausea experienced by chemotherapy‐naïve cancer patients.Method:  Twenty‐eight cancer patients receiving emetogenic cytotoxic agents were assigned to one of three groups. During the three day study period following their first chemotherapy session, Control Group patients (n = 9) continued with their normal diet, Protein Group patients (n = 9) were provided with a protein drink (ProSure®; 15 g protein) and 1 g of dried ginger root to consume twice daily, and High Protein Group patients (n = 10) were provided with a protein drink with additional protein powder (ProSure® and ProMod®; 31 g protein) and 1 g of dried ginger root to consume twice daily. All patients were asked to complete a symptom diary over the three days to assess the severity, frequency, and bothersomeness of the nausea they experienced, as well as their use of antiemetic medication. Gastric myoelectrical activity was assessed by electrogastrography as five patients ingested a protein meal with ginger on the first morning of the study.Results:  Reports of nausea, of nausea being experienced often, and of nausea being bothersome were significantly less frequent in the High Protein Group than in the Control and Protein Groups (ps < 0.05); the Control and Protein Groups were not significantly different from each other. Furthermore, significantly fewer patients in the High Protein Group elected to use antiemetic medication than patients in the other two groups (p < 0.05). A significant increase in normal gastric myoelectrical activity, and a significant decrease in gastric tachyarrhythmia, the gastric dysrhythmia that frequently accompanies nausea, occurred with ingestion of the protein meals and ginger (ps < 0.05).Conclusions:  High protein meals with ginger reduced the delayed nausea of chemotherapy, and reduced the use of antiemetic medications. Anti‐nausea effects of high protein meals with ginger were associated with enhancement of normal gastric myoelectrical activity and decreased gastric dysrhythmias. High protein meals with ginger represent a novel, nutritionally based treatment for the delayed nausea.
28 The alteration of multi‐channel Electrogastrography and autonomic nervous system function in patients with gastroesophageal reflux disease with test meal
Authors: XU X , DING Z , WANG Z , SONG Z , CHEN X , KE M 
Published: May 2006

The aims of this study were to utilize multi‐channel electrogastrography (MEGG) and power spectra analysis of Heart Rate Variability (HRV) to investigate the effects of test meal on MEGG and autonomic nervous system (ANS) function in patients with gastroesophageal reflux disease (GERD).Methods:  Sixteen patients with the diagnosis of GERD were enrolled in this study (11 M, 5 F, mean age: 47 yrs) and 16 healthy subjects (HS) matched for age and gender were recruited as control (11 M, 5 F, mean age: 47 yrs). MEGG was recorded simultaneously with the electrocardiogram (ECG) recording for 30 min in the fasting state and 60 min after a standard test meal (450 Kcal). MEGG parameters included dominant frequency (DF), dominant power (DP), the normal percentage of 2–4 cpm gastric slow waves (%N) and the percentage of slow wave coupling (%SWC). ANS parameters included sympathovagal balance LF/HF Ratio, mainly sympathetic activity LF and vagal activity HF.Results:  (1) Compared with fasting state, test meal significantly increased the DF but decreased the %N and %SWC in both GERD patients and HS in the 1st 30 min and 2nd 30 min fed state (P < 0.05). DP was not significantly altered by test meal in both groups in fed state. However, there is no significant difference between 1st 30 min and 2nd 30 min fed state for DF, %N and %SWC. 2) Compared with fasting state, test meal significantly increased the LF/HF ratio and LF but decreased the HF in both groups in the 1st 30 min after meal (P < 0.05), however, the increase of LF/HF ratio and LF but decrease of HF were still present in HS whereas absent in patients with GERD in the 2nd 30 min fed state. There is no significant difference between 1st 30 min and 2nd 30 min fed state for those ANS parameters. (3) There was no significant difference between GERD patients and HS in any of those MEGG and ANS parameters neither in fasting state nor in fed state. (4) There was no significant correlation between MEGG parameters and ANS parameters neither in fasting state nor in fed state in both groups.Conclusions:  Both patients with GERD and HS may have similar response to test meal in MEGG test. GERD patients could not maintain the response to test meal longer in ANS test suggests that GERD patients may have impaired ANS regulation to test meal.
33 Effect of afferent vagal stimulation through oral exposure to a sour or a salty taste on gastric myoelectrical activity evaluated by means of multi‐channel electrogastrography
Authors: DZIELICKI M , JONDERKO K , DOMOSLAWSKA E , WALUGA M , KASICKA‐JONDERKO A , BLONSKA‐FAJFROWSKA B 
Published: May 2006

Aim:  To determine if sensory stimulation with a salty or a sour taste would affect the interdigestive gastric myoelectrical activity (GMA) in humans.Methods:  Eighteen healthy volunteers (10 F, 8 M) were subjected on two separate days to four‐channel electrogastrographic recordings divided into consecutive 35 min periods: (i) basal fasted; (ii) a stimulation epoch while a subject was chewing an agar cube soaked with a taste‐delivering substance (Sodium chloride for the salty taste, citric acid for the sour taste) and (iii) a post‐stimulatory (recovery) epoch. An electrocardiogram was simultaneously registered for the purpose of the heart rate variability (HRV) analysis.Results:  Exposure to the salty taste increased both the power of the low frequency (LF: 0.04–0.15 Hz) band and the low to high frequency (LF/HF) power ratio of the power spectrum‐analysed HRV data. The sour taste did not affect the HRV. During the stimulation and the recovery epoch either in the case of the salty or the sour taste a statistically significant augmentation in the relative time share of tachygastria within the multi‐channel electrogastrogram was observed. Exposure to the salty taste resulted in a statistically significant decrease in the fraction of the coupled gastric slow waves. Moreover, the time‐share of bradygastria rose slightly but statistically significantly in response to the stimulation with the salty taste. On the other hand, the sour taste elicited a significant decline in the dominant power of the gastric slow waves.Conclusions:  (i) Oral exposure to a salty taste elicits a sympathetic arousal reflected by an increase in the LF power and the LF/HF power ratio, whereas a sour taste does not change the balance between the parasympathetic and the sympathetic constituent of the autonomous nervous system; (ii) the increment in tachygastria appears to be an unspecific phenomenon because it was evoked by stimulation with either the salty or the sour taste and (iii) the inhibitory effect on the GMA of the exposure to the sour taste is reflected by a dumping of the dominant power, whereas the stimulation with the salty taste is followed by an uncoupling of the gastric slow waves and an increase in bradygastria.
39 Gastrointestinal electrical stimulation in post‐surgical gastroparesis improves symptoms independently while gastric emptying response is dependent on baseline emptying
Authors: SCHMIEG RE , MINOCHA A , ABIDI N , ABELL TL 
Published: May 2006

Introduction:  Temporary GES (tempGES) can improve both gastric emptying and symptoms in post‐surgical gastroparesis (PS‐GP). (SSAT 2004). Long‐term effects on GI symptoms and gastric emptying are unknown. Since many PS‐GP patients have non‐delayed emptying, the long‐term effect on baseline normal or rapid emptying is also unknown.Patients:  36 pts (6 M, 30 F, mean age 42 years) with post‐surgical: Bilroth I (n = 11), Bilroth II (n = 4), other gastric surgery (n = 21) disordered gastric emptying were evaluated.Methods:  GI symptoms (vomiting = V, Total = TSS), and solid meal gastric emptying (GET) at 1 and 4 h, were compared at baseline (Base), after temporary (tempGES) and permanent (permGES) gastric electrical stimulation as previously described (NGM, 2004; 16: 635.) Long‐term follow‐up for permanent GES ranged from 6 month to 10 years. Results were compared by t‐tests, and are reported as means ± SEM.Results:  29 of the 36 patients were able to tolerate food for baseline quantitative gastric emptying testing. 20 patients had delayed and 9 patients had non‐delayed gastric emptying, with 7/9 being rapid. With both tempGES and permGES, GI symptoms improved (p < 0.05). Both tempGES and permGES showed accelerated GET for delayed patients and generally slowed GET for non‐delayed (p < 0.05 for 1 h values). See tables below.Conclusions:  In a large group of post‐surgical GP patients, temporary and permanent gastrointestinal electrical stimulation improved GI symptoms independent of gastric emptying and for a prolonged time. GES improves symptoms independent of baseline gastric emptying, and improves GET dependent on the baseline gastric emptying.

Groups
All
Delayed
Non‐delayed

N = 36
N = 20
N = 9

V
TSS
V
TSS
V
TSS

Base
3.5 ± 0.7
15.6 ± 0.5
3.2 ± 0.2
16.0 ± 0.6
4.6 ± 2.9
15.7 ± 1.0

Temp
0.8 ± 0.3
6.1 ± 1.2
0.9 ± 0.4
5.4 ± 1.7
1.0 ± 0.8
7.9 ± 3.5

Perm
1.2 ± 0.3
9.3 ± 1.2
0.8 ± 0.3
7.6 ± 1.3
1.8 ± 0.4
10.3 ± 3.9
44 Sacral extracorporeal magnetic stimulation is an effective treatment for pelvic floor dyssynergia; Comparative study with biofeedback therapy
Authors: LEE JS , IM HH , JUNG Y , JUNG IS , JANG JY , CHUN YK , CHO YD , KIM JO , CHO JY , KIM YS , SHIM CS , KIM BS 
Published: May 2006

Background:  Recent development of extracorporeal magnetic stimulation (ECMS) which uses current‐changing magnetic fields allows the induction of electrical stimulation in the desired deep tissue. Recent study showed the sacral nerve stimulation reduces corticoanal excitability that may play a functional role in anal continence mechanisms. Preliminary study shows that ECMS of sacral nerve can modify pelvic floor function and expel rectal balloon in patients with pelvic floor dyssynergia (PFD).Aims:  To evaluate the effect of ECMS compared with biofeedback therapy (BF) in patients with PFD.Methods and Materials:  Thirty‐eight patients who fulfilled Rome II criteria for PFD by colon transit time and anorectal function tests, were randomly treated with 8 sessions of ECMS (2/weeks; n = 19) at prone position or BF (2/weeks; n = 19) at sitting position. Stimulation parameters were set at 50–80% of maximum intensity, 10 and 50 Hz frequency, 3 s burst length with 3 and 6 s off using arm‐typed stimulator (BioCom‐1000, Mcube Co., Korea). Symptom scores for constipation with/without anorectal function test were repeatedly measured after each treatment. Response was defined as 50% or more decreased symptom score after treatment (partial response: 30–50%, poor: <30%).Results:  Fifteen patients (age 49.1 ± 13.4 years, mean ± SD; 4 men) completed 8 session of BF and 14 patients (54.5 ± 17.6 years, 3 men) completed 8 session of ECMS. Four patients of BF group discontinued treatment due to unsatisfactory therapeutic effect (n = 1) and withdrew consent (n = 3) and 5 patients of ECMS group discontinued treatment because of same reasons (n = 1, 4). Total symptom scores were significantly decreased after treatment of 8 session in both treatment groups (13.4 ± 6.6 vs. 4.3 ± 4.0 for BF, p = 0.009; 14.9 ± 5.6 vs. 3.4 ± 4.0 for ECMS, p < 0.001). Bowel movements per week were also significantly increased after treatment in both groups (median 2 vs. 7 for BF, p = 0.035; median 2 vs. 7 for ECMS, p = 0.008). Thirteen out of 15 patients showed response in BF group and 12 out of 14 showed good response in ECMS group. No adverse effects in both groups.Conclusions:  ECMS is as effective as BF for the treatment of PFD. Long‐term effect of ECMS for the patients with pelvic floor dyssynergia need to be evaluated in the near future.
45 Gastric electrical stimulation and sacral electrical stimulation: are two devices better than one?
Authors: JAIN S , AL‐JUBURI A , BRIZZOLORA J , SECREST CL , WHITE P , ABELL TL 
Published: May 2006

Introduction:  Gastric Electrical Stimulation (GES) is available as a Humanitarian Use Device for patients with the symptoms of gastroparesis and is effective in reducing gastrointestinal symptoms. We have previously shown that patients with gastric motor disorders often have co‐existing abnormalities of the genitourinary system (Gastroenterol 112: A737, 1997), which may now be treated with sacral electrical stimulation (SES), resulting in similar improvements in genitourinary symptoms.Patients:  We compared the results of therapy with GES and SES in 13 patients who were implanted with both devices. Patients were 11 f, 2 m, mean age of 41 years, who had documented gastroparesis as well as bladder or other pelvic floor dysfunction. All 13 patients had received their GES before the SES.Methods:  Patients were evaluated at baseline and latest follow up (median 4 years for GES and 2 years for SES), according to previously standardized scores of GI (GI: 0–4, TSS max 20) and GU (GU: 0–3, UTSS, max 12) function. Results were compared by paired t‐tests and reported as mean ± SE.Results:  All 13 patients improved both GI and GU symptoms and the improvement in all parameters as nausea, vomiting, anorexia, bloating, abdominal pain and gastric total symptom score (TSS), leakage, urgency, voiding difficulty, number of pads used and urinary total symptom score (UTSS) were statistically significant (see table below).Conclusions:  The combination of GES and SES appears to be both safe and effective for patients with con‐comitant gastroparesis and bladder dysfunction and the existence of a stimulator for one disorder does not preclude another stimulator.

Vomiting
Nausea
Anorexia
Bloating
Abd. Pain
TSS

Before
2.75 ± 0.62
3.96 ± 0.13
3.46 ± 1.08
3.57 ± 0
3.79 ± 0.11
16.00 ± 1.05

After
0.63 ± 0.18
1.03 ± 0.07
1.63 ± 0.07
1.89 ± 0.36
1.29 ± 0.25
6.64 ± 0.94

P.Value
<0.001
<0.001
<0.001
<0.002
<0.001
<0.001

Leakage
Urgency
Voiding Difficulty
#Pads
UTSS

Before
1.33 ± 0.49
2.0 ± 0.51
2.43 ± 0.43
0.83 ± 0.48
6.5 ± 1.28

After
0
0.67 ± 0.42
0.5 ± 0.31
0
1.4 ± 0.75

P.Value
<0.001
0.007
0.002
0.007
<0.001
46 The feasibility of duodenum electrical stimulation to produce gastrointestinal symptoms in a clinical trial
Authors: STECCO KA , BASHYAM JA , HABEEB MA , HABIBULLAH CM , IMRAN MA 
Published: May 2006

Introduction:  Proximal duodenal electrical stimulation with various energy parameters has been investigated as a possible treatment for various gastrointestinal (GI) myoelectrical diseases. Wide pulse width (millisecond) stimulation in the proximal duodenum can disrupt or entrain the normal myoelectrical rhythm and provide a potential feedback pathway to alter normal gastric function such as emptying, fundus tone, and intra‐gastric pressure and subsequently produce specific symptoms that could affect eating behaviors. A specific level of electrical stimulation is necessary to elicit symptoms and serve as an indicator that energy parameters are adequate. However, there has been no published data correlating electrical threshold stimulation with symptom characterization. The goal of this study was to determine the average minimum pulse width necessary to elicit GI symptoms.Methods:  Eight patients underwent endoscopic placement of intraluminal electrodes in the proximal duodenum. Each patient received electrical stimulation in the millisecond (ms) range starting with a pulse width of 100 ms that was increased by intervals of 100 ms up to a maximum pulse width of 500 ms. The pulse repetition frequency was fixed at 12 CPM and each regimen was repeated for amplitudes ranging from 2 milliamps (mA) to 10 mA. Gastrointestinal symptom scores consisting of nausea, vomiting, satiety, fullness, pain, bloating and other, were taken at baseline and after each regimen change.Results:  There was an average minimum threshold necessary for elicitation of symptoms (293.7 + 41.7 ms, p‐value = 0.063). The three most frequently reported GI symptoms were crampy abdominal pain, fullness, and bloating.Conclusions:  Electrical stimulation of the duodenum is feasible. A certain minimum threshold of duodenal electrical stimulation is necessary to elicit GI symptoms in patients. The intensity and patient tolerability of each specific GI symptom was able to be adjusted by changing a certain energy parameter within a regimen. Further research is warranted to evaluate the ability of duodenal electrical stimulation to produce GI symptoms that may alter eating behaviors.