bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preparation of derivatives of 1‐(2‐pyrimidinyl)piperazine as potential antianxiety, antidepressant, and antipsychotic agents
Authors: Becker Irwin 
Published: March 2009

Abstractmagnified imageThis paper describes the preparation of twenty‐eight derivatives of 1‐(2‐pyrimidinyl)piperazine as potential antianxiety, antidepressant, and antipsychotic agents. In twenty‐six of the preparations a chloro nitrogen heterocycle was caused to react with an excess of 1‐(2‐pyrimidinyl)piperazine in the absence of solvent. A specific example is given above.
Synthesis of some novel pyrazolo[1,5‐a]pyrimidine, 1,2,4‐triazolo[1,5‐a]pyrimidine, pyrido[2,3‐d]pyrimidine, pyrazolo[5,1‐c]‐1,2,4‐triazine and 1,2,4‐triazolo[5,1‐c]‐1,2,4‐triazine derivatives incorporating a thiazolo[3,2‐a]benzimidazole moiety
Authors: Abdel‐Aziz Hatem A. , Hamdy Nehal A. , Fakhr Issa M. I. , Farag Ahmad M. 
Published: March 2009

Abstractmagnified imageE‐3‐(N,N‐Dimethylamino)‐1‐(3‐methylthiazolo[3,2‐a]benzimidazol‐2‐yl)prop‐2‐en‐1‐one (2) was synthesized by the reaction of 1‐(3‐methylthiazolo[3,2‐a]benzimidazol‐2‐yl)ethanone (1) with dimethylformamide‐dimethylacetal. The reaction of2with 5‐amino‐3‐phenyl‐1H‐pyrazole (4a) or 3‐amino‐1,2,4‐(1H)‐triazole (4b) furnished pyrazolo[1,5‐a]pyrimidine and 1,2,4‐triazolo[1,5‐a]pyrimidine derivatives6aand6b, while the reaction of enaminone2with 6‐aminopyrimidine derivatives7a,bafforded pyrido[2,3‐d]pyrimidine derivatives9a,b, respectively. The diazonium salts11aor11bcoupled with compound2to yield the pyrazolo[5,1‐c]‐1,2,4‐triazine and 1,2,4‐triazolo[5,1‐c]‐1,2,4‐triazine derivatives13aand13b. Some of the newly synthesized compounds exhibited a moderate effect against some bacterial and fungal species.
Regioselective synthesis of heterocyclic scaffold by aryl radical cyclization
Authors: Majumdar K. C. , Kundu N. 
Published: March 2009

Abstractmagnified imageRegioselective synthesis of a number of coumarin‐annulated pentacyclic heterocycles have been achieved by tri‐n‐butyltin hydride‐mediated aryl radical cyclization. The products are formed as a mixture of cis‐ and trans‐ forms which were successfully separated by careful silica gel flash chromatography.
Synthesis of some oxazolyl ‐ pyrazolyl; 1,4‐Dihydropyridinyl‐pyrazolyl and 1,2,3,4‐tetrahydro pyrimidinyl‐pyrazolyl coumarins
Authors: Patel Mehul A. , Brahmbhatt Dinker I. 
Published: March 2009

Abstractmagnified imageVarious 3‐[1‐phenyl‐4‐(2‐substituted‐5‐oxo‐oxazol‐4‐ylidenemethyl) pyrazol‐3‐yl] coumarins 4a‐f; 3‐[1‐phenyl‐4‐(2,6‐dimethyl‐3,5‐disubstituted‐1,4‐dihydropyridin‐4‐yl) pyrazol‐3‐yl] coumarins 5a‐f and 3‐[1‐phenyl‐4‐(6‐methyl‐5‐substituted‐2‐oxo‐1,2,3,4‐tetrahydropyrimidin‐4‐yl) pyrazol‐3‐yl] coumarins 6a‐f have been synthesized utilizing Erlenmyer‐Plochl reaction, Hantzsch reaction and Biginelli reaction respectively using 3‐(1‐phenyl‐4‐formyl‐pyrazol‐3‐yl) coumarins 3a‐c as a starting material.
Ketene dithioacetals‐source for different heterocycles
Authors: Padmavathi Venkatapuram , Reddy Gali Sudhakar , Deepti Duvvuru , Padmaja Adivireddy 
Published: March 2009

Abstractmagnified imageSome pyrazoline, isoxazoline and pyrimidine derivatives were synthesized from ketene dithioacetals using appropriate nucleophiles.
A convenient synthesis of novel 1,3,4‐triaryl‐3,4‐dihydropyrimidin‐2(1H)‐ones by cyclization of aromatic isocyanates with β‐arylamino‐1‐phenylpropan‐1‐ones
Authors: Hu Yongzhou , Lu Xiuyang , Xue Na 
Published: March 2009

Abstractmagnified imageA simple one‐step method for preparation of novel 1,3,4‐triaryl‐3,4‐dihydropyrimidin‐2(1H)‐ones has been developed by reaction of aromatic isocyanates with β‐arylamino‐1‐phenylpropan‐1‐ones in refluxing toluene in the presence of KHSO4 and HCl.
Microwave‐assisted regioselective one‐pot synthesis of trisubstituted pyridine scaffolds using K5CoW12O40.3H2O under solvent free conditions
Authors: Kantevari Srinivas , Chary Mahankhali Venu , Vuppalapati Srinivasu V. N. , Lingaiah N. 
Published: March 2009

Abstractmagnified imageA highly efficient, microwave‐assisted, regioselective synthesis of 2,3‐disubstituted‐6‐arylpyridines and new series of 7,7‐dimethyl‐2‐aryl‐5,6,7,8‐tetrahydroquinoline‐5‐ones from enaminones in the presence of K5CoW12O40.3H2O (1.0 mol %) as heterogeneous catalyst under solvent free conditions is reported.
Unsymmetrical indirect covariance processing of hyphenated and long‐range heteronuclear 2D NMR spectra ‐ Enhanced visualization of 2JCH and 4JCH correlation responses
Authors: Martin Gary E. , Hilton Bruce D. , Blinov Kirill A. , Williams Antony J. 
Published: March 2009

Abstractmagnified imageRecent reports have demonstrated the unsymmetrical indirect covariance combination of discretely acquired 2D NMR experiments into spectra that provide an alternative means of accessing the information content of these spectra. The method can be thought of as being analogous to the Fourier transform conversion of time domain data into the more readily interpreted frequency domain. Hyphenated 2D‐NMR spectra such as GHSQC‐TOCSY, when available, provide an investigator with the means of sorting proton‐proton homonuclear connectivity networks as a function of the 13C chemical shift of the carbon directly bound to the proton from which propagation begins. Long‐range heteronuclear chemical shift correlation experiments establish proton‐carbon correlations via heteronuclear coupling pathways, most commonly across three bonds (3JCH), but in more general terms across two (2JCH) to four bonds (4JCH). In many instances 3JCH correlations dominate GHMBC spectra. We demonstrate in this report the improved visualization of 2JCH and 4JCH correlations through the unsymmetrical indirect covariance processing of GHSQC‐TOCSY and GHMBC 2D spectra.
6‐Nitro‐1,2,3,4‐tetrahydroquinolines by a tandem reductive amination‐SNAr reaction
Authors: Bunce Richard A. , Nago Takahiro 
Published: March 2009

Abstractmagnified imageA tandem reductive amination‐SNAr reaction has been developed for the synthesis of 6‐nitro‐1,2,3,4‐tetrahydroquinolines. Treatment of 4‐(2‐fluoro‐5‐nitrophenyl)‐2‐butanone or 3‐(2‐fluoro‐5‐nitrophenyl)‐propanal with primary amines and sodium cyanoborohydride in methanol at room temperature provided good to excellent yields of the substituted tetrahydroquinolines. The reaction proceeded best with the ketone substrate using primary amines that were unbranched at the α‐carbon. The aldehyde also produced the target heterocycles, but these were accompanied by 10‐15% of the uncyclized side chain reductive amination products.
First synthesis of selenadiazolo[3,4‐i] Benzazepine derivatives
Authors: Abou Elmaaty Tarek M. 
Published: March 2009

Abstractmagnified image5‐Methyl‐4‐nitro‐2,1,3‐benzoselenadiazole (1) was converted into (E)‐5‐(2‐dimethylamino)vinylbenzo‐[c](1,2,5)selenadiazole‐4‐amine (4) by initial treatment with dimethylformamide dimethyl acetal (DMFDMA) (2) followed by selective reduction using ammonium bromide in methanol. Compound 4 afforded the selenadiazolo[3,4‐i][1]benzazepine derivatives (7, 10, 13, 15) upon treatment with malononitrile (5), ethyl cyanoacetate (8) and cyanoacetamide (11) respectively.
Chemoselective reaction of formalin with 2‐(5‐substituted‐2‐hydroxybenzylamino)phenols: Synthesis of 6‐substituted 3‐(2‐hydroxyphenyl)‐3,4‐dihydro‐2H‐benzo[e][1,3]oxazines
Authors: Manikannan Ramaiyan , Muthusubramanian Shanmugam 
Published: March 2009

Abstractmagnified imageReaction of 2‐(5‐substituted‐2‐hydroxybenzylamino)phenols (2) with formalin in ethanol under reflux has chemoselectively led to 2‐(6‐substituted‐2H—benzo[e][1,3]oxazin‐3(4H)‐yl)phenols (3) in good yield involving the ring closure of the hydroxyl group of the C‐aryl ring and not that of the N‐aryl ring.
Selective modification of bifunctional heterocyclic compounds containing amino and thioamide groups in acetic acid medium
Authors: Kolmakov Kirill A. 
Published: March 2009

Abstractmagnified imageIn acetic acid medium, 2‐chloro‐4,6‐dimorpholin‐4‐yl‐[1,3,5]triazine undergoes amination by bifunctional heterocyclic compounds containing both amino and thioamide groups. The reactions are high‐yielding and selective; the thioamide functions are unaffected under the requisite conditions. The reactions do not proceed in satisfactory yields in other solvents and, thus, require acetic acid. The resulting thioamides, consisting of multiple biologically relevant residues, are easily alkylated at the sulfur (thiolthione) centers to furnish new thioethers in subsequent steps.
Synthesis of pyrazolo[3,4‐b]pyridines using ammonium acetate as green reagent in multi‐component reactions
Authors: Jachak Madhukar N. , Avhale Appasaheb B. , Ghotekar Bhausaheb K. , Kendre Dhananjay B. , Raghunath B. Toche 
Published: March 2009

Abstractmagnified imageSeveral new pyrazolo[3,4‐b]pyridine derivatives were synthesized by one pot cyclocondensation of the components; 5‐amino‐3‐aryl‐1H‐phenylpyrazoles, p‐substituted benzoylacetonitriles and some aldehydes. The condensations were most effective by using ammonium acetate as the base catalyst; triethylamine was also studied as a catalyst.
Synthesis and characterization of N‐arylsulfonylazetidines
Authors: Tan Songde , Chen Yiwen , Zingaro Ralph A. , Reibenspies Joseph H. 
Published: March 2009

Abstractmagnified imageA convenient method for the synthesis of N‐arylsulfonyl azetidines using N‐(3‐bromopropyl)‐arylsulfonamide with cesium carbonate and potassium iodide in DMF is reported. The reaction conditions are optimized and seven N‐arylsulfonyl azetidines have been synthesized in good yield using this method. The structures of compounds 2a and 2e were determined by X‐ray crystallography.
Synthesis of new imidazole derivatives
Authors: Nowak Krystyna , Szpakiewicz Barbara 
Published: March 2009

Abstractmagnified imageThe derivatives of 1‐propyl‐ and 1‐butyl‐ of 2‐methyl‐5‐nitroimidazole containing phenylpiperazine, m‐chloro‐ and o‐methoxyphenylpiperazine attached at the end of alkyl chain were synthesed. For the obtained new compounds, the biological activity was predicted using the computer program PASS.
Convenient preparations of 2‐alkyl‐5‐oxopyrrolidine‐3‐carboxylic acids
Authors: Photiadou Anna D. , Stathakis Christos I. , Gallos John K. 
Published: March 2009

Abstractmagnified imageReduction of the Michael addition products of anions of nitro compounds to dimethyl maleate led to the spontaneous formation of the respective 2‐alkyl‐5‐oxopyrrolidine‐3‐carboxylic acid methyl esters. Conventional hydrolysis of the later gave the desired compounds.
Regioselective photocyclization of (e)‐2‐(2,3,6‐trichlorostyryl)‐benzothiazole and synthesis of 3,4‐dichloro‐ and 4‐chlorobenzothiazolo[3,2‐α]quinolinium chlorides: A synthetic and theoretical study
Authors: Cox Osvaldo , Garcia Carmelo , Cordero Marisol 
Published: March 2009

Abstractmagnified imageA high degree of regioselectivity is observed in the photochemically induced cyclization of (E)‐2‐(2,3,6‐trichlorostyryl)benzothiazole (1a). According to the proposed mechanism, this compound was expected to afford two products, 3,4‐dichloro‐ and 1,4‐dichlorobenzothiazolo[3,2‐α]quinolinium chlorides (4aand4a', respectively). However, this reaction produced 3,4‐dichlorobenzazolo[3,2‐α]quinolinium chloride (4a) as the sole product. On the other hand, irradiation of (E)‐2‐(2,3,5‐trichlorostyryl)benzothiazole (1b) failed to produce the expected 1,3‐dichlorobenzothiazolo[3,2‐α]quinolinium chloride (4b). Furthermore, (E)‐2,3‐difluorostrylbenzothiazole (1c) also failed to give the corresponding 1‐fluorobenzothiazolo[3,2‐α]quinolinium fluoride (4c). Interestingly, the irradiation of 2,6‐dichlorostyrylbenzothialole (1d) produced 4‐chlorobenzothiazolo[3,2‐α]quinolinium chloride (4d) in excellent yield. This paper presents the results of these investigations and a mechanistic rationale for the outcome of this reaction based on steric arguments and theoretical studies using a combination of molecular mechanics (MM+) and semiempirical quantum mechanical calculations (PM3/RHF/CI). Two‐dimensional high field nmr methods were employed to make complete assignments of the proton and carbon spectra of all new compounds.
Synthesis, asymmetric aldol reactions, and x‐ray crystallography of some oxadiazinanone derivatives
Authors: Hitchcock Shawn R. , Davis Ryan A. , Richmond Daniel M. , Dore Delvis D. , Kuschel Stephanie L. , Vaughn Jeremy F. , Wolfe Jesse A. , Hamaker Christopher G. , Casper David M. , Dingle Jarvis 
Published: March 2009

Abstractmagnified imageA series of N4‐substituted oxadiazinanones have been synthesized from (1R,2S)‐norephedrine by a process of either reductive alkylation or arylation, N‐nitrosation, reduction and cyclization. These derivatives (R = ‐CH2Ph, ‐CH2C(CH3)3, ‐cyclo‐C6H11, ‐C6H5) have been acylated with propanoyl chloride and employed in the asymmetric Aldol reaction. The observed diastereoselectivities for the formation of the “non‐Evans” syn‐adduct ranged from 88:12 to 99:1. The hydrolysis of the Aldol adducts varied with the nature of the nitrogen substituent.
Pot, atom and step economic synthesis of fused three heterocyclic ring compounds under microwave irradiation in water
Authors: Shi Feng , Zhou Dianxiang , Tu Shujiang , Li Chunmei , Cao Longji , Shao Qingqing 
Published: March 2009

Abstractmagnified imageA new series of fused three heterocyclic ring compounds, consisting of a pyrazolo (ring A), a pyridine (ring B), and a pyrimidine (ring C) core, pyrazolo[4′,3′:5,6]pyrido[2,3‐d]pyrimidine derivatives were successfully synthesized by pot, atom and step economic (PASE) method under microwave irradiation in the presence of p‐toluene sulphonic acid in water.
Multicomponent reactions in chiral ionic liquids: A stereocontrolled route to mercaptopyranothiazoles
Authors: Yadav Lal Dhar S. , Yadav Beerendra S. , Rai Vijai K. 
Published: March 2009

Abstractmagnified imageA low hazardous, one‐pot, expeditious annulation involving tandem Knoevenagel, Michael and ring transformation reactions of 3‐arylrhodanines, aromatic aldehydes and a mercaptoacetyl transfer agent, 2‐methyl‐2‐phenyl‐1,3‐oxathiolan‐5‐one, diastereoselectively yields 6‐mercaptopyranothiazoles. The annulation is performed using a chiral ionic liquid (Pro2SO4) as the reaction medium and catalyst, and proceeds via an isolable intermediate.
Anion recognition properties of the neutral receptors bearing amide macrocycle
Authors: Shang X.‐F. , Cai Z.‐S. , Lin H.‐K. , Lin H. 
Published: March 2009

Abstractmagnified imageNeutral classes of amide‐based macrocycle have been synthesized and the anion binding abilities are assessed by UV‐vis titration and 1H nmr experiments. Results indicate that higher anion binding abilities are observed for H2PO4−, F− and AcO−, but almost no affinity for Cl−, Br−, I− and OH−. The 1H nmr spectra shows that the interactions between the receptors and fluoride anion depend on two factors, respectively: one is depend on hydrogen bonding, the other on deprotonation.
Synthesis and bio‐activity of novel iminophosphoranes
Authors: Mohan Ch. , Babu B. Hari , Raju C. Naga , Reddy C. Suresh , Reddy V. Janardhan 
Published: March 2009

Abstractmagnified imageThe title compounds (5a‐j) were synthesized by a two step process. 4‐Chlorophenyl and bis(2‐chloroethyl) amino‐dibromophosphites (1a and 1b) were reacted with 1,8‐diaminonaphthalene (2) to form the diazaphosphinines (3a and 3b). They were further reacted with different alkyl azides (4a‐e) in THF at 50‐55 °C under N2 atmosphere to afford the corresponding iminophosphoranes (5a‐j). Their structures were established by elemental analysis, IR, 1H, 13C, 31P NMR and Mass spectral data. All of them exhibited moderate antibacterial activity.
Oxidation of bisnaphthols to spironaphthalenones, revisited
Authors: Khoramabadi‐Zad Ahmad , Yavari Isaa , Shiri Azam , Bani Azad 
Published: March 2009

Abstractmagnified imageBis(2‐hydroxy‐1‐naphthyl)methane derivatives have been efficiently converted to their corresponding spirans through three methods, i.e. oxidation by TCCA under mild reaction conditions, Ph3Bi catalyzed air oxidation, and by electrochemical reaction. The first two methods are diastereoselective and give either of the two possible diastereomers, while the electrochemical method produces equal amounts of these diastereomers.
Syntheses of potassium 1,1‐dioxopyrido[4,3‐e]‐1,4,2‐dithiazine‐3‐thiolate and its application to the synthesis of novel sulfonamides with potential biological activity
Authors: Brzozowski Zdzislaw , Sâczewski Franciszek , Slawiński Jaroslaw 
Published: March 2009

Abstractmagnified imagePotassium 1,1‐dioxopyrido[4,3‐e]‐1,4,2‐dithiazine‐3‐thiolate 2 has been synthesized and applied to the syntheses of 7H‐1,1‐dioxopyrido[4,3‐e]‐1,4,2‐dithiazolium‐3‐thiolate 3 and 3‐methylthiopyrido[4,3‐e]‐1,4,2‐dithiazine 1,1‐dioxide 4 which provided easy access to a variety of its 3‐amino derivatives 5‐10. Hydrazinolysis of 7, 8 and 10 afforded the corresponding 3‐amino‐2‐(1,4‐dihydro‐4‐thioxopyrid‐3‐ylsulfonyl)guanidines 11‐13. Subsequent reaction of 12 with 4‐chlorobenzaldehyde gave condensation product 14. 1,4‐Dihydro‐2‐thioxopyridine‐3‐sulfonamide 15 was also prepared from the potassium salt 2 upon alkaline hydrolysis, whereas alkylation of 15 gave the appropriate S‐substituted derivatives 16‐19 or S,N‐disubstituted compounds 20‐21.
Phenacyl esters of acetic acid derivatives and their application for the synthesis of 2‐oxo‐4‐phenyl‐5‐(phenylhydrazono)‐2,5‐dihydro‐furan‐3‐derivatives
Authors: Hlaváč Jan , Hradil Pavel , Mělnický Radek , Kvapil Lubomír , Šlézar Petr , Grepl—— Martin , Hradil Pavel , Lyčka Antonín , Grepl Martin 
Published: March 2009

Abstractmagnified imageCoupling of various substituted phenacyl acetates 1 and diazonium salts 3 was studied. If the phenacyl acetates were substituted by an electronaceptor group such as CN or COOEt 3‐substituted phenyl‐5‐(phenyl‐hydrazono)‐5H‐furan‐2‐ones 4 were formed. Also synthesis of aza and diaza analogs is described. The compounds were characterized using MS and NMR spectroscopy.
Synthesis of novel symmetrical bis‐schiff bases of 5,5′‐methylenebis(2‐aminothiazole)
Authors: Shockravi Abbas , Sadeghpour Mahdieh , Olyaei Abolfazl 
Published: March 2009

Abstractmagnified imageNovel symmetrical bis‐Schiff bases have been prepared cleanly and efficiently in the presence of formic acid catalyst in methanol from the reaction of symmetrical primary bis‐amine of 5,5′‐methylenebis(2‐aminothiazole) (1) and a series of aromatic aldehyde derivatives under mild conditions. The advantages of this reaction are simplicity of the reaction procedure, simple work‐up and pure products with high yields. The structures of all the new synthesized symmetrical bis‐Schiff bases were confirmed by elemental analyses, IR, 1H‐NMR, 13C‐NMR and mass spectra.
Synthesis and biological activity of 3‐[(6‐chloropyridin‐3‐yl)methyl]‐6‐substituted‐6,7‐dihydro‐3H‐1,2,3‐triazolo[4,5‐d]‐pyrimidin‐7‐imines
Authors: Chen Xiao‐Bao , Shi De‐Qing 
Published: March 2009

Abstractmagnified imageA series of 3‐[(6‐chloropyridin‐3‐yl)methyl]‐6‐substituted‐6,7‐dihydro‐3H‐1,2,3‐triazolo[4,5‐d]pyrimidin‐7‐imines were designed and synthesized via a multi‐step sequence using 2‐chloro‐5‐(chloromethyl)‐pyridine as the starting material. Various primary aliphatic amines, hydrazine and hydrazide reacted with 3 to obtain the cyclization products 4. Their structures were confirmed by 1H NMR and elemental analyses, some of them were also confirmed by IR, 13C NMR, MS and single crystal X‐ray diffraction. The preliminary bioassay indicated that some of the target compounds 4 displayed moderate to weak fungicidal activity and insecticidal activity.
Synthesis and reactions of n‐methyl‐4‐(methylthio)thieno[2,3‐d]‐pyrimidinium salts
Authors: Maruoka Hiroshi , Okabe Fumi , Yamagata Kenji 
Published: March 2009

Abstractmagnified imageTwo methods for the preparation of N‐methyl‐4‐(methylthio)thieno[2,3‐d]pyrimidinium salts 6a,b and 13a,b are described. Treatment of 6a,b and/or 13a,b with active methylene compounds such as malononitrile and ethyl cyanoacetate in the presence of sodium methoxide caused nucleophilic addition followed by elimination of methanethiol, giving the corresponding N‐methyl‐4‐ylidenethieno[2,3‐d]‐pyrimidines 7a,b, 8a,b, 14a,b and 15a,b.
The reaction of cyclohexanone azine with cyanoacetic acid‐acetic anhydride
Authors: Nakhai Azadeh , Bergman Jan , Raftery Jim , Joule John A. 
Published: March 2009

Abstractmagnified imageThe reaction of cyclohexanone azine with a reagent produced by brief heating of cyanoacetic acid with acetic anhydride produced a highly substituted dihydropyrazolone.
Diverse reactivity of α‐carbanions derived from alkylidenephosphoranes toward 2‐(1λ5‐diazynylidene)‐1H‐indene‐1,3‐(2H)dione. General approach to conjugated oxadiazines, pyridazines and spiro[3]pyrazoles
Authors: Abdou Wafaa M. , Khidre Maha D. , Khidre Rizk E. 
Published: March 2009

Abstractmagnified imageDifferent types of phosphonium carbanions were applied to 2‐diazonio‐1,3‐dioxo‐2,3‐dihydro‐1H‐inden‐2‐ide (1) in order to synthesize a number of condensed and fused N‐heterocycles. When 1 was treated with cyanomethyltriphenylphosphonium chloride oxadiazine‐, and pyridazine derivatives were obtained whereas bis‐indanylidene derivatives resulted from the reaction of 1 with methyl_ and ethyltriphenylphosphonium bromides. On the other hand, a series of substituted and unsubstituted spiro[3′]pyrazoles were obtained from the di azo substrate when reacted with vinyl_and allyltriphenylphosphonium bromides.
1‐Arylsulfonyl‐2‐styrylsulfonylthenes — source for a new class of bis heterocycles
Authors: Padmavathi Venkatapuram , Radhalakshmi Thunga , Reddy Gali Sudhakar , Padmaja Adivireddy 
Published: March 2009

Abstractmagnified imageNew and novel sulfone linked bis heterocycles_ bis pyrroles and pyrrolyl pyrazolines are prepared from 1‐arylsulfonyl‐2‐styrylsulfonylethenes by 1,3‐dipolar cycloaddition methodology.
Synthesis and characterization of some substituted chromones as an anti‐infective and antioxidant agents
Authors: Rode Milind , Gupta R. C. , Karale B. K. , Rindhe S. S. 
Published: March 2009

Abstractmagnified imageA series of substituted chromones were synthesized and characterized by spectral data. Some of the synthesized compounds were tested for in‐vitro antibacterial, antifungal and antioxidant activity. Two compounds have shown very good antioxidant activity and some of the chromone derivatives have exhibited moderate antibacterial and antifungal activity.
Synthesis of a novel class of 3‐(2′‐benzothiazolyl)‐2,3‐dihydroquinazolin‐4(1H)‐ones under solvent‐free and catalyst‐free conditions
Authors: Shaabani Ahmad , Rahmati Abbas , Moghimirad Jafar 
Published: March 2009

Abstractmagnified imageA solvent‐ and catalyst‐free one‐pot three‐component condensation reaction approach was developed for the synthesis of a new class of 3‐(2′‐benzothiazolyl)‐2,3‐dihydroquinazolin‐4(1H)‐ones in relatively good yields.
Synthesis and mutagenic potency of structural isomers of 2‐amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine
Authors: Chrisman W. , Tanga M. J. , Knize M. G. 
Published: March 2009

Abstractmagnified imageSynthesis of 2‐amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine (PhIP), three structural isomers, and two desphenyl PhIP congeners has been carried out. Mutagenic potency was evaluated using S. typhimurium strain TA98 in the Ames test. Mutagenic potency increased in relation to structural features in these heterocyclic amines that allow extended resonance between the phenyl and imidazo[4,5‐b]pyridine N2‐amino substituents. By contrast, PhIP isomers, whose substitution disallows involvement of the phenyl group in their aminoimidazo resonance hybrids, and desphenyl congeners were from 86‐ to 234‐fold less mutagenic than PhIP.