bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transcriptional rewiring of an evolutionarily conserved circadian clock
Authors: Goity Alejandra , Dovzhenok Andrey , Lim Sookkyung , Hong Christian , Loros Jennifer , Dunlap Jay C , Larrondo Luis F 
Published: April 2024

AbstractCircadian clocks temporally coordinate daily organismal biology over the 24-h cycle. Their molecular design, preserved between fungi and animals, is based on a core-oscillator composed of a one-step transcriptional-translational-negative-feedback-loop (TTFL). To test whether this evolutionarily conserved TTFL architecture is the only plausible way for achieving a functional circadian clock, we adopted a transcriptional rewiring approach, artificially co-opting regulators of the circadian output pathways into the core-oscillator. Herein we describe one of these semi-synthetic clocks which maintains all basic circadian features but, notably, it also exhibits new attributes such as a “lights-on timer” logic, where clock phase is fixed at the end of the night. Our findings indicate that fundamental circadian properties such as period, phase and temperature compensation are differentially regulated by transcriptional and posttranslational aspects of the clockworks.
Amphiphilic electrolyte additive as an ion-flow stabilizer enables superb zinc metal batteries
Authors: Yang Zimin , Sun Yilun , Deng Siting , Tong Hao , Wu Mingqiang , Nie Xinbin , Su Yifan , He Guanjie , Zhang Yinghe , Li Jianwei , Chai Guoliang 
Published: April 2024

3-(Hydroxy(phenyl)phosphoryl)propanoic acid (HPA) has a strong coordination ability for Zn2+/metal anodes which not only form sphere micelles that promote the uniform transmission of Zn2+ but also enhance the preferential adsorption on anodes.
Reliability and Validity of the Turkish Version of the Vanderbilt Fatigue Scale for Adults
Authors: Taşdemir İlknur , Türkyılmaz Meral Didem , Hornsby Benjamin W. Y. 
Published: April 2024

Purpose:
Listening-related fatigue (LRF) is a prominent topic of research interest. The purpose of this study is to investigate the reliability and validity of the Turkish version of the 40-item Vanderbilt Fatigue Scale for Adults (TR-VFS-A-40).

Method:
This study included 317 adults with no hearing loss and 260 adults with hearing loss in the study group, totaling 577 adults aged 18–75 years. While 31 adults in the study group did not use any hearing technology, there were 96 hearing aid users and 123 cochlear implant (CI) users. A subset of 80 CI users completed the TR-VFS-A-40 a second time, 2 weeks later, to assess test–retest reliability. Intraclass correlation coefficients were used to assess test–retest reliability. Cronbach's alpha was used to evaluate internal consistency. To examine construct validity, a confirmatory factor analysis (CFA) was performed. For concurrent validity analysis, the Checklist Individual Strength (CIS) and TR-VFS-A-40 scores were analyzed using the Spearman correlation test.

Results:
Cronbach's alpha values were excellent for the total scale of .987 and the cognitive, emotional, physical, and social subscales (.953, .954, .955, and .946, respectively). Analyses of concurrent validity revealed strong and significant correlations between CIS and TR-VFS-A-40 scores, indicating a good concurrent validity. The CFA determined that the construct validity of the TR-VFS-A-40 was satisfactory.

Conclusion:
The TR-VFS-A-40 is a valid and reliable measure of LRF.

Supplemental Material:

https://doi.org/10.23641/asha.25457752
Nonlinear control of coaxial double rotor magnetic gear based on high gain observer in wind turbine
Authors: Habibi Hamideh , Aminnzhad Amanj , Khosrowjerdi Mohammad Javad 
Published: April 2024

AbstractThis paper proposes a nonlinear control law with a dynamic controller based on high gain observer (HGO) for a co‐axial double rotor magnetic gear (CADRMG) based on Halbach array used in wind turbines. The generalized canonical form (GCF) is used to normalize the nonlinear augmented system to achieve the dynamic control signal with a chain of integrator of system output. In addition, a tracking problem is defined to track high speed rotor (HSR) with respect to GCF. On the other hand, the HGO is used to estimate the error tracking at the expense of nonlinear terms. Furthermore, the nonlinear system observability of the augmented system is evaluated. A dynamic control law is used to solve the tracking problem based on HGO. This controller can eliminate the effect of load torque as a constant and unknown disturbance in the closed‐loop system. Moreover, the closed‐loop stability of the system under dynamic signal control is guaranteed. The system states estimation is calculated by recursive equations from tracking error estimations. Finally, numerical simulations are given to illustrate the theoretical results of proposed system.
Direct synthesis approach to design PDμ${\text{PD}}^\mu$ based smith predictor for integrating plants: Studied on a quadrotor UAV
Authors: Ranjan Anjana , Mehta Utkal , Prakash Surya , Azid Sheikh Izzal 
Published: April 2024

AbstractThis article presents a simple yet novel method of designing a fractional‐order proportional derivative (namely, ) controller for all types of integrating plants. Considering the importance of the direct synthesis approach, the method obtains robust closed‐loop performance. The setpoint parameter is obtained using the multi‐optimization Pareto solution, considering the optimal values in control efforts and performance index together. The numerical investigations have shown improved servo and regulatory responses compared to recently published strategies with fractional orders. It is also known that classical PIDs cannot accurately follow a ramp setpoint. A real‐world situation also demands that the reference inputs become an acceleration ramp type. The proposed technique can handle rising ramp setpoints with plant uncertainty and measurement noise. Hardware verification is also performed on a quadrotor minidrone to check for real‐time issues.
Perceptions par les médecins généralistes des bénéfices de leur thèse d’exercice : une étude qualitative
Authors: Rault Matthieu , Banâtre Agnès , Lucas Gilles , Myhié Didier , Maury Arnaud 
Published: April 2024

Contexte : La thèse d’exercice en médecine générale est à la fois un travail de recherche, un outil d’apprentissage du troisième cycle et le symbole de la fin des études médicales. Il existe un doute quant à son utilité scientifique. Objectif : L’objectif était d’explorer les perceptions de médecins généralistes sur les bénéfices de leur travail de thèse. Méthode : Ce travail est une étude qualitative respectant les recommandations de la grille COREQ, à partir de 14 entretiens semi-dirigés, conduits jusqu’à saturation des données, analysés selon une approche inductive en s’inspirant des principes de la phénoménologie complétée par une modélisation. Résultats : Malgré l’obligation initiale, la thèse d’exercice était considérée comme un fardeau utile développant des compétences professionnelles. Les médecins étaient plus sceptiques quant à la valeur scientifique de leur thèse. La solitude, l’amateurisme, l’errance méthodologique, le manque de temps étaient les freins évoqués. Un sujet personnel, la mutualisation du travail, le soutien méthodologique et humain, l’anticipation étaient les leviers de la réussite. La portée symbolique de la soutenance empiétait sur sa dimension universitaire. Le titre de docteur, la reconnaissance par les pairs et l’engagement envers la société sont des retombées importantes pour les médecins. Les axes d’amélioration identifiés étaient : expliciter les objectifs pédagogiques, accompagner les internes sur le plan méthodologique, dédramatiser et rendre passionnante la thèse. Conclusion : Certains leviers facilitants pourraient être activés rapidement à la fois par les directeurs de thèse et par les départements de médecine générale comme mieux définir le cadre scientifique et pédagogique, désamorcer l’aspect symbolique et favoriser le travail en commun.
The chronic pancreatitis (CP) Type Cambridge 2 as a cause of unclear upper abdominal pain: a radiologically underestimated diagnosis
Authors: Schaible Jan , Grenacher Lars , Stroszczynski Christian , Schreyer Andreas G. , Huber Lorenz , Bäumler Wolf 
Published: April 2024

AbstractThe time interval from symptom onset to the diagnosis of chronic pancreatitis (CP) remains disproportionately long today due to nonspecific symptoms and the absence of a definitive laboratory marker. Nevertheless, mortality is increased by 3.6 times compared to the general population. Additionally, the risk of developing pancreatic carcinoma is 16 times higher in the presence of CP. According to the current S3 guideline, the morphological staging of CP should be based on the Cambridge Classification for CT/MRCP. Most radiologists morphologically associate CP with Cambridge Stage 4, which is characterized by classic calcifications. The subtle morphologies of earlier Cambridge Stages are often unrecognized, leading to delayed diagnosis. The aim of this study was to diagnose CP at Cambridge Stage 2 as the cause of unexplained upper abdominal discomfort.A retrospective analysis was conducted on 266 patients with unexplained upper abdominal pain who underwent outpatient MRI with MRCP between January 1, 2021, and October 1, 2023. The criteria for Cambridge Stage 2 were evaluated: pancreatic duct in the corpus measuring between 2 and 4 mm, pancreatic hypertrophy, cystic changes < 10 mm, irregularities in the duct, or > 3 pathological side branches. Patients with known tumors or other leading diagnoses, which explained the discomfort, were excluded.25 patients (15 female, 10 male) met the criteria for CP Stage 2 (9%). Ductal dilation between 2 and 4 mm was visible in 21 cases. Pancreatic hypertrophy was observed in six cases. Cystic changes < 10 mm were identified in three cases. Irregularities in the duct (“wavy duct”) were diagnosed in 19 patients. Dilation of > 3 side branches was recognized in 17 cases. Lipase levels were additionally determined, with 13 patients showing pathologically elevated levels (> 60 U/l).CP at Cambridge Stage 2 is an important and underestimated diagnosis in patients with unexplained upper abdominal pain in the outpatient setting. Radiologists should pay attention not only to common signs like calcifications, large cysts, or duct strictures but also to subtle changes such as duct irregularities (“wavy duct configuration”) and pathologically dilated side branches, which could lead to a significantly earlier diagnosis of CP. Lipase determination may be an additional indication of chronic pancreatitis in this context.
Ein Sturm zieht auf … der „Thyroid Storm“ als seltener endokrinologischer Notfall im Notarztdienst
Authors: Ventzke Marc-Michael 
Published: April 2024

ZusammenfassungBis auf Störungen des Glukosestoffwechsels sind endokrinologische Notfälle vor allem in der präklinischen Situation sehr selten. Die thyreotoxische Krise stellt eine Rarität unter den Krankenhausbehandlungen und erst recht im Notarztdienst dar. Klare Diagnosekriterien hierfür existieren nicht, sodass das gesamte klinische Bild des Patienten betrachtet werden muss. Allerdings stehen Bewertungsskalen zur Verfügung, mit denen der Verdacht erhärtet werden kann. Die präklinischen Therapieoptionen sind begrenzt. Die klinische Therapie muss im intensivmedizinischen Umfeld erfolgen.
Tripeptide-Catalyzed Asymmetric Michael Addition Reaction of β-Nitrostyrenes with Cyclohexanone
Authors: Kohari Yoshihito , Kippei Maeda , Takeyama Mitsuki , Murata Miki 
Published: April 2024

AbstractA tripeptide catalyst derived from natural l-amino acids was employed in the reaction of β-nitrostyrenes with cyclohexanone, serving as a model for the asymmetric Michael addition reaction. The reaction was conducted in the presence of H-Pro-Tle-Gly-OH and 2-fluoro-4-chlorobenzoic acid as co-catalysts (each at 20 mol%) in DMF-H2O (5:1) at 0 °C for 3 days. This process yielded the desired Michael adducts with excellent efficiency and good stereoselectivity (up to 98% yield, up to 92% ee).
Isolated or Combined Ascending Aortic Replacement through a Partial Sternotomy: Early and Midterm Outcomes
Authors: Angerer Matthias , Pollari Francesco , Hitzl Wolfgang , Weber Lucia , Sirch Joachim , Fischlein Theodor 
Published: April 2024

Abstract
Background We aimed to investigate the in-hospital and midterm outcomes of patients undergoing ascending aortic replacement (AAR) through a partial or a full sternotomy approach through a propensity matching analysis.
Methods We retrospectively included all patients (n = 167) who underwent elective AAR in our institution between 2013 and 2020. The study population was divided into two groups according to the surgical access (40 patient in the partial sternotomy or “PS” group and 127 in the full sternotomy or “FS” group). Due to the significant differences between the groups, a propensity matching of 1:3 was applied. In-hospital complications, survival, and reoperation at follow-up were investigated.
Results The PS group showed higher cross-clamp and cardiopulmonary bypass times than the FS group (94.2 vs. 83 minutes and 164.2 vs. 126.8 minutes, respectively). Moreover, the postoperative ventilation time was significantly higher in the PS group, but it did not affect the length of stay in the intensive care unit (ICU). The incidences of bleeding, stroke, and mortality were comparable between the two groups (11 vs. 3%, 3 vs. 6%, and 5 vs. 3%, respectively). After a median follow-up of 2 ± 1.98 years, the Kaplan–Meier analysis showed no significant differences between the two groups (log-rank, p = 0.17) in terms of survival.
Conclusion The surgical ascending aorta replacement through a partial sternotomy is associated with longer operative times, but this does not affect the early as well as the long-term follow-up.
Managing One-Lung Ventilation in Tracheostomized Patients: A 6-Year Retrospective Analysis
Authors: Golditz Tobias , Schmidt Joachim , Ackermann Andreas , Danzl Anja , Birkholz Torsten , Sirbu Horia , Irouschek Andrea 
Published: April 2024

Abstract
Background To ensure safe and optimal surgical conditions in thoracic surgery, one-lung ventilation is crucial. Various techniques exist to achieve one-lung ventilation. Tracheotomized patients who require one-lung ventilation represent a unique and rare subgroup that demands specialized knowledge and skills. The very limited literature has discussed alternative methods, no randomized controlled trials have addressed this issue yet.
Methods We performed a retrospective analysis of patients who underwent one-lung ventilation in the Department of Thoracic Surgery of a German University Hospital between 2016 and 2021. The study assessed patient demographics, airway management techniques, ventilation parameters, and adverse events.
Results In 3,197 anesthesia procedures during the observation period, 152 patients had an existing tracheostomy, of which 56 required one-lung ventilation. Among others in 42 cases, a tracheostomy tube was combined with a bronchial blocker, and in 10 cases, a double-lumen tracheostomy tube was used. There were no severe complications. Intraoperative dislocations that required repositioning of the device occurred in six patients (13.3%) with bronchial blockers and one patient with double-lumen tracheostomy tube (10%).
Conclusion The management of one-lung ventilation in tracheotomized patients presents unique challenges. While double-lumen tracheostomy tubes have specific advantages, we recommend considering their use carefully. For most tracheotomized patients, bronchial blockers in conjunction with a tracheostomy tube are used, which offers safety and practicality, irrespective of the tracheostomy's age or type. Further research and randomized controlled trials are warranted to establish best practices for one-lung ventilation in this unique patient population.
An Update on Brain Death/Death by Neurologic Criteria since the World Brain Death Project
Authors: Lewis Ariane 
Published: April 2024

AbstractThe World Brain Death Project (WBDP) is a 2020 international consensus statement that provides historical background and recommendations on brain death/death by neurologic criteria (BD/DNC) determination. It addresses 13 topics including: (1) worldwide variance in BD/DNC, (2) the science of BD/DNC, (3) the concept of BD/DNC, (4) minimum clinical criteria for BD/DNC determination, (5) beyond minimum clinical BD/DNC determination, (6) pediatric and neonatal BD/DNC determination, (7) BD/DNC determination in patients on ECMO, (8) BD/DNC determination after treatment with targeted temperature management, (9) BD/DNC documentation, (10) qualification for and education on BD/DNC determination, (11) somatic support after BD/DNC for organ donation and other special circumstances, (12) religion and BD/DNC: managing requests to forego a BD/DNC evaluation or continue somatic support after BD/DNC, and (13) BD/DNC and the law. This review summarizes the WBDP content on each of these topics and highlights relevant work published from 2020 to 2023, including both the 192 citing publications and other publications on BD/DNC. Finally, it reviews questions for future research related to BD/DNC and emphasizes the need for national efforts to ensure the minimum standards for BD/DNC determination described in the WBDP are included in national BD/DNC guidelines and due consideration is given to the recommendations about social and legal aspects of BD/DNC determination.
The virtue and shades of aggressive humour in press advertising
Authors: Stwora Anna 
Published: April 2024

AbstractDisparaging humour may take numerous forms and despite the emotional ambivalence it may occasionally cause, it may prove a valuable quality of an ad. While investigating one hundred multimodal press ads in English that simultaneously make use of metaphor and humour based on an incongruity-resolution mechanism, it was discovered that one-third thereof employed aggressive humour as well (Stwora 2023). Given the high incidence of the aggressive function in these ads, this paper explores this disparaging dimension in more detail to show that various shades of aggressiveness may be perceived as a virtue when used in advertising discourse. The paper advocates a need to consider further sub-categorisations of the aggressive function of humour when applied in advertising to reflect different hostility levels.
Non-modal voice quality in Chilean Spanish
Authors: Bolyanatz Mariška 
Published: April 2024

Abstract
Since the turn of the 21st century, research on phonation (the production of sound via the vibration of the vocal folds, also known as voice quality) has increased significantly. However, non-modal phonation is highly understudied in Spanish. Therefore, this study comprises a sociophonetic analysis of voice quality in Spanish, examining voice quality categorically from sociolinguistic interview speech conducted with 41 native monolingual Chilean Spanish speakers. The aim of the present paper is to interrogate how phonation varies among residents of Santiago, Chile. Specifically, it asks: what is the sociolinguistic distribution of non-modal voice quality in Chilean Spanish? How does this distribution align with work on voice quality in Spanish and in other languages? Results indicate that non-modal voice quality is used by speakers to mark prosodic boundaries such as phrase finality, aligning with robust cross- linguistic findings. Non-modal phonation is also incorporated when speakers are reporting speech, as well as when they are speaking about emotionally-charged subjects. I draw connections between these findings and those of other dialects of Spanish, and show that utterance-final devoicing, while often associated with “tierras altas” dialects of Spanish, may be more frequent in other dialects than previously indicated. I argue that further examinations of non-modal phonation should also examine third-wave approaches of attitude, emotion, and stance.
Introduction to translating Etkind
Authors: Eade Roberts Suzanne 
Published: April 2024

Abstract
The text is a translation from Russian of the first chapter of Soviet theorist Efim Etkind’s 1963 work Poeziia i perevod [Poetry and Translation], in slightly abridged form. Etkind
is a vital figure within the translation milieu of the ‘Thaw’ era of the late 1950s and early 1960s, when there was a policy of
de-Stalinization and a degree of liberalization. Etkind’s insightful work on poetry translation using comparative stylistics
reflected, in some ways, the cultural-political environment of the time. It differed radically from the Realist approach of Ivan
Kashkin, who was influenced by Socialist Realism and Stalin-era rhetoric. Etkind pushed the boundaries of what could be said about
translation. His apparently apolitical approach was in fact strongly politicized in the Soviet context, and his choice of authors
and translators to discuss evidenced his sympathy for those out of favor with the regime and for fellow Jews.
Radiation of a TM mode from an open end of a three-layer dielectric capillary
Authors: Galyamin Sergey N. , Altmark Alexandr M. 
Published: April 2024

Abstract
Modern trends in beam-driven radiation sources include the interaction of Cherenkov wakefields in open-ended circular waveguides with complicated dielectric linings, with a three-layer dielectric capillary recently proposed to reduce radiation divergence being a representative example [Opt. Lett.
45 5416 (2020)]. We present a rigorous approach that allows for an analytical description of the electromagnetic processes that occur when the structure is excited by a single waveguide TM mode. In other words, the corresponding canonical waveguide diffraction problem is solved in a rigorous formulation. This is a continuation of our previous papers which considered simpler cases with a homogeneous or two-layer dielectric filling. Here we use the same analytical approach based on the Wiener–Hopf–Fock technique and deal with the more complicated case of a three-layer dielectric lining. Using the obtained rigorous solution, we discuss the possibility of manipulating the far-field radiation pattern using a third layer made of a low permittivity material.
Subpicosecond laser ablation behavior of a magnesium target and crater evolution: Molecular dynamics study and experimental validation
Authors: Jiang 江 Guolong 国龙 , Zhou 周 Xia 霞 
Published: April 2024

Abstract
The micro-ablation processes and morphological evolution of ablative craters on single-crystal magnesium under subpicosecond laser irradiation are investigated using molecular dynamics (MD) simulations and experiments. The simulation results exhibit that the main failure mode of single-crystal Mg film irradiated by a low fluence and long pulse width laser is the ejection of surface atoms, which has laser-induced high stress. However, under high fluence and short pulse width laser irradiation, the main damage mechanism is nucleation fracture caused by stress wave reflection and superposition at the bottom of the film. In addition, Mg[0001] has higher pressure sensitivity and is more prone to ablation than Mg

[
10

1
¯

0
]

. The evolution equation of crater depth is established using multi-pulse laser ablation simulation and verified by experiments. The results show that, under multiple pulsed laser irradiation, not only does the crater depth increase linearly with the pulse number, but also the quadratic term and constant term of the fitted crater profile curve increase linearly.