bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations between monitor-independent movement summary (MIMS) and fall risk appraisal combining fear of falling and physiological fall risk in community-dwelling older adults
Authors: Choudhury Renoa , Park Joon-Hyuk , Banarjee Chitra , Coca Miguel Grisales , Fukuda David H. , Xie Rui , Stout Jeffrey R. , Thiamwong Ladda 
Published: April 2024

Introduction: Fall Risk Appraisal (FRA), a process that integrates perceived and objective fall risk measures, serves as a crucial component for understanding the incongruence between fear of falling (FOF) and physiological fall risk in older adults. Despite its importance, scant research has been undertaken to investigate how habitual physical activity (PA) levels, quantified in Monitor-Independent Movement Summary (MIMS), vary across FRA categories. MIMS is a device-independent acceleration summary metric that helps standardize data analysis across studies by accounting for discrepancies in raw data among research-grade and consumer devices.Objective: This cross-sectional study explores the associations between MIMS (volume and intensity) and FRA in a sample of older adults in the United States.Methods: We assessed FOF (Short Falls Efficacy Scale-International), physiological fall risk (balance: BTrackS Balance, leg strength: 30-s sit-to-stand test) and 7-day free-living PA (ActiGraph GT9X) in 178 community-dwelling older adults. PA volume was summarized as average daily MIMS (MIMS/day). PA intensity was calculated as peak 30-min MIMS (average of highest 30 non-consecutive MIMS minutes/day), representing a PA index of higher-intensity epochs. FRA categorized participants into following four groups: Rational (low FOF-low physiological fall risk), Irrational (high FOF-low physiological fall risk), Incongruent (low FOF-high physiological fall risk) and Congruent (high FOF-high physiological fall risk).Results: Compared to rational group, average MIMS/day and peak 30-min MIMS were, respectively, 15.8% (p = .025) and 14.0% (p = .004) lower in irrational group, and 16.6% (p = .013) and 17.5% (p &lt; .001) lower in congruent group. No significant differences were detected between incongruent and rational groups. Multiple regression analyses showed that, after adjusting for age, gender, and BMI (reference: rational), only irrational FRA was significantly associated with lower PA volume (β = −1,452.8 MIMS/day, p = .034); whereas irrational and congruent FRAs were significantly associated with lower “peak PA intensity” (irrational: β = −5.40 MIMS/day, p = .007; congruent: β = −5.43 MIMS/day, p = .004).Conclusion: These findings highlight that FOF is a significant barrier for older adults to participate in high-intensity PA, regardless of their balance and strength. Therefore, PA programs for older adults should develop tailored intervention strategies (cognitive reframing, balance and strength exercises, or both) based on an individual’s FOF and physiological fall risk.
Evaluating the effectiveness of COVID-19 vaccines in adults with sickle cell disease during the Omicron period of COVID-19 pandemic
Authors: Aldecoa Kim Abbegail Tan , Macaraeg Chef Stan L. , Arsene Camelia , Krishnamoorthy Geetha , Chng Tiffany , Cherry Garrett , Chowdhury Nabila , Clark Ryan , Deeb Dana , Deptula Lisa , Dietz Grey , Eto Ewomamobuho , Golston Victoria , Lawson Landon , Mbionwu Chioma , Okponyia Obiefuna , Orejuela Jennifer , Qipo Thomaidha , Raut Sumit , Goodman Judie 
Published: April 2024

Background and aimsThe Omicron variant, one of the variants causing the coronavirus disease of 2019 (COVID-19), was first identified in November 2021 and became the predominant variant in 2022. Although causing less severe disease, this variant and its subvariants have been associated with increased transmissibility and limited protection despite vaccination and prior infection. Individuals with sickle cell disease (SCD) are particularly at greater risk of severe illness and death, and studies regarding the effectiveness of COVID-19 vaccination have been limited in this population. The study aims to determine the effectiveness of COVID-19 vaccination during this period among individuals with SCD and to examine various factors that can influence the likelihood of COVID-19 infection and severity among SCD individuals.MethodsThis is a retrospective analysis of adult patients (≥18 years) with SCD who had emergency and inpatient encounters between January 1 and December 31, 2022. Multivariable regression analysis was performed to determine the effectiveness of the COVID-19 vaccine among this population.ResultsThe study found that COVID-19 vaccination lowered the infection risk among SCD individuals by over 70% if they have received at least one dose of the vaccine. The study also found that individuals with SCD and a history of acute chest syndrome were over 3 times more likely to have a COVID-19 infection diagnosis than those without a history of acute chest syndrome.ConclusionThe study confirms the effectiveness of the COVID-19 vaccine among individuals with SCD during the Omicron period of the COVID-19 pandemic.
Nine New Species of Ilyarachninae Hansen, 1916 (Crustacea: Isopoda: Munnopsidae) from Australia and New Zealand with an Updated Key of the Subfamily from the Southwest Pacific
Authors: Merrin Kelly L. 
Published: April 2024

The Ilyarachninae are a diverse and widely distributed subfamily of the asellote family Munnopsidae. This paper describes nine new deep-sea species from two Ilyarachninae genera, Ilyarachna and Notoapais, from the southwestern Pacific, namely from New Zealand and the east coast of Australia. Ilyarachna aculeatus n. sp., Ilyarachna brucei n. sp., Ilyarachna franki n. sp., Ilyarachna mclayi n. sp., Ilyarachna pacifica n. sp., Ilyarachna sami n. sp., Ilyarachna taranui n. sp. and Notopais chathamensis n. sp. are described from New Zealand waters, while Notopais likros n. sp. is described from off the east coast of Australia. Additionally, a redescription of Notopais spinosa from the Balleny Islands, Antarctica, and a revised key to the Ilyarachna and Notopais species from the southwest Pacific are included, and the distribution, affinities, and diagnostic characters of the new species are discussed.
A Comparative Study to Assess Knowledge and Perception Regarding Leucorrhoea among Women of Reproductive Age Group in Selected Rural and Urban Areas of Ludhiana, Punjab
Authors: Ramandeep Kaur  
Published: April 2024

Leucorrhoea is a thick, whitish vaginal discharge. It is a symptom, not a disease. Subjectively and objectively it is an expression of some underlying disorder, either functional or organic. A comparative study was conducted to assess the knowledge and perception regarding leucorrhoea among 100 women of reproductive age group by using convenience sampling technique. The finding of the present study revealed that highly positive co- relation was found between knowledge and perception regarding leucorrhoea, r = 0.8 for rural area and r= 0.9 for urban area, indicated the highly positive co- relation between knowledge and perception regarding leucorrhoea. Hence it is further recommended to this study on large sample for better generalization. Similar study can be conductedby using qualitative approach using in-depth interviews and on OPD patients i.e. with leucorrhea.
ШАРДАРА СУАРУ АЛҚАБЫНЫҢ МАҚТА АУЫСПАЛЫ ЕГІС ДАҚЫЛДАРЫНДАҒЫ ЖЕР АСТЫ СУЛАРЫНЫҢ РӨЛІ
Authors: Рау Алексей , Калыбекова Есенкуль , Сейтасанов Ибрагим , Зулпибекова Сандугаш , Арыстанов Мейрам 
Published: April 2024

Мақалада Түркістан облысындағы Шардара суару алқабының сұр топырақты мақта ауыспалы егісінде жүргізілген зерттеу нәтижелері келтірілген.
Осы жылғы далалық зерттеулер мақта ауыспалы егіс дақылдарын өсірудегі сұр топырақтың, дәнді және көкөніс дақылдарын өсірудегі қоңыр және қара топырақтардың агроресурстық әлеуетін анықтады. Шардара суғару алқабының табиғи-климаттық жағдайы мақта ауыспалы егіс дақылдарын өсіру үшін қолайлы екені анықталды, ауаның орташа жылдық температурасы +12,5°с, температураның 10°С – тан жоғары қосындысы 4600-4800°с-қа тең, радиация жылына 60 ккал/см2/құрайды. Аллювиалды топырақ, егістік қабатының көлемдік массасы – 1,3 – 1,4 г/см3, кеуектілігі 48-50%, сүзу коэффициенті 0,08-0,26 м/тәул., тұз мөлшері-0,2–0,4%, жер асты суларының деңгейі 0,5–3,0 м, минералдылығы 1,2-3,7 г/л.
38731 га алқапта мақта егілді, суару мөлшері 10600-15300 м3/га, өнімділігі 22,2-24,65 ц/га. Суару каналдарының жалпы ұзындығы 91798,2 км құрайды, оның ішінде 12190,0 км шаруашылықтан тыс және 79718,2 км шаруашылықта.
Суармалы егіншіліктегі қиындықтар дренаж желісінің нашар жұмыс істеуінен, магистральдық арналардан сүзілуден, шаруашылықішілік суару жүйелерін ұтымсыз пайдаланудан және басқа да жағымсыз факторлардан туындайды. Соның салдарынан республикада 300 мың гектарға дейін суармалы жер қанағаттанарлықсыз жағдайда, ал бір млн.гектардан астам жер қолданыстағы суару желілерін түбегейлі жақсартуды талап етеді.
In vitro cytotoxic and genotoxic effects of Phyllanthus niruri extract loaded chitosan nanoparticles in TM4 cells and their influence on spermatogenesis
Authors: Sadaqa Ebrahim , Utami Ratna Annisa , Mudhakir Diky 
Published: April 2024

Purpose: This paper introduces a complete in vitro investigation of cytotoxic and genotoxic effects of Phyllanthus niruri extract loaded chitosan nanoparticles (PNNP) on mouse Sertoli cell line (TM4), as well as their impact on spermatogenesis.
Methods: Chitosan nanoparticles (ChNP) and PNNP were prepared using an ionic gelation process, while their cytotoxicity on TM4 cells was assessed using the Cell Counting Kit-8 (CCK-8) assay. Comet and fast halo assays were used to quantify single-strand DNA breaks in TM4 cells. To detect changes in cell morphology during apoptosis, nuclear staining with Hoechst 33342 was performed. An immunofluorescence assay was employed to examine the expression level of proteins connexin 43 and Claudin 11 in TM4 cells after exposure to PNNP concentration of 125 µg/mL.
Results: The synthesized PNNP had a size of 170.6 nm, a polydispersity index of 0.269, a zeta potential of +37.8 mV, and a good entrapment efficiency of 71.0%. Encapsulation of Phyllanthus niruri into ChNP induced DNA damage in TM4 cells as determined by alkaline comet and fast halo assay (FHA). Additionally, it stimulated apoptosis, as determined by changes in cell morphology by Hoechst 33342 staining. There was significant down regulation of blood-testis barrier (BTB) proteins in TM4 cells after exposure to PNNP which could compromise the integrity of BTB and subsequently disrupt spermatogenesis process in male.
Conclusion: Our investigation confirms the cytotoxic and genotoxic effects of PNNP in TM4 cells, which could lead to spermatogenesis disruption and male infertility.
Changes in Corneal Epithelial Thickness in Different Areas After Femtosecond Laser–Assisted LASIK in Patients With High Astigmatism
Authors: Li Anqi , Liu Zhichao , Lin Meng , Gong Qianwen , Wei Linzhi , Lu Fan , Hu Liang 
Published: April 2024

Purpose:
To explore changes in corneal epithelial thickness (CET) after femtosecond laser–assisted laser in situ keratomileusis in patients with high astigmatism.

Methods:
CET was measured at every intersection of the concentric circles and specific axes using AngioVue optical coherence tomography (Angio-OCT) preoperatively and 1 month postoperatively. The average thickness of corneal central, paracentral, and peripheral regions was the mean of the points within the central 2, 2 to 5, and 5 to 7 mm areas, respectively. Correlation analysis was performed to investigate the association between CET along different axes and other preoperative and postoperative parameters.

Results:

Forty-two eyes of 28 patients were included. CET along the astigmatic (K1) and perpendicular (K2) axes in the central and paracentral areas increased (
P
< .001), whereas that along the K2 axis decreased in the peripheral area 1 month postoperatively (
P
= .001). The amount of CET change in the peripheral area between the K1 and K2 axes was significantly different (
P
< .001). In the central area, the change in CET along the K2 axis was positively correlated with ablation depth (
r
= 0.315,
P
= .042) and negatively with refractive power after surgery (
r
= −0.347,
P
= .024). In the peripheral area, the changes in CET along both K1 and K2 axes were negatively correlated with ablation depth (
r
= −0.431,
P
= .004;
r
= −0.387,
P
= .011, respectively).

Conclusions:
Epithelial modeling differed between the different astigmatism axes after refractive surgery. The compensatory response of the corneal epithelium is more pronounced along the steeper axis.

[
J Refract Surg
. 2024;40(4):e239–e244.]
Efficacy and predictive factors of transarterial chemoembolization combined with lenvatinib plus programmed cell death protein-1 inhibition for unresectable hepatocellular carcinoma
Authors: Ma Kun-Peng , Fu Jin-Xin , Duan Feng , Wang Mao-Qiang 
Published: April 2024

BACKGROUND
The efficacy and safety of transarterial chemoembolization (TACE) combined with lenvatinib plus programmed cell death protein-1 (PD-1) for unresectable hepatocellular carcinoma (HCC) have rarely been evaluated and it is unknown which factors are related to efficacy.
AIM
To evaluate the efficacy and independent predictive factors of TACE combined with lenvatinib plus PD-1 inhibitors for unresectable HCC.
METHODS
This study retrospectively enrolled patients with unresectable HCC who received TACE/lenvatinib/PD-1 treatment between March 2019 and April 2022. Overall survival (OS) and progression-free survival (PFS) were determined. The objective response rate (ORR) and disease control rate (DCR) were evaluated in accordance with the modified Response Evaluation Criteria in Solid Tumors. Additionally, the prognostic factors affecting the clinical outcome were assessed.
RESULTS
One hundred and two patients were enrolled with a median follow-up duration of 12.63 months. The median OS was 26.43 months (95%CI: 17.00-35.87), and the median PFS was 10.07 months (95%CI: 8.50-11.65). The ORR and DCR were 61.76% and 81.37%, respectively. The patients with Barcelona Clinic Liver Cancer Classification (BCLC) B stage, early neutrophil-to-lymphocyte ratio (NLR) response (decrease), or early alpha-fetoprotein (AFP) response (decrease > 20%) had superior OS and PFS than their counterparts.
CONCLUSION
This study showed that TACE/lenvatinib/PD-1 treatment was well tolerated with encouraging efficacy in patients with unresectable HCC. The patients with BCLC B-stage disease with early NLR response (decrease) and early AFP response (decrease > 20%) may achieve better clinical outcomes with this triple therapy.
Safety and efficacy of a programmed cell death 1 inhibitor combined with oxaliplatin plus S-1 in patients with Borrmann large type III and IV gastric cancers
Authors: Bao Zhe-Han , Hu Can , Zhang Yan-Qiang , Yu Peng-Cheng , Wang Yi , Xu Zhi-Yuan , Fu Huan-Ying , Cheng Xiang-Dong 
Published: April 2024

BACKGROUND
Gastric cancer (GC) is the fifth most common and the fourth most lethal malignant tumour in the world. Most patients are already in the advanced stage when they are diagnosed, which also leads to poor overall survival. The effect of postoperative adjuvant chemotherapy for advanced GC is unsatisfactory with a high rate of distant metastasis and local recurrence.
AIM
To investigate the safety and efficacy of a programmed cell death 1 (PD-1) inhibitor combined with oxaliplatin and S-1 (SOX) in the treatment of Borrmann large type III and IV GCs.
METHODS
A retrospective analysis (IRB-2022-371) was performed on 89 patients with Borrmann large type III and IV GCs who received neoadjuvant therapy (NAT) from January 2020 to December 2021. According to the different neoadjuvant treatment regimens, the patients were divided into the SOX group (61 patients) and the PD-1 + SOX (P-SOX) group (28 patients).
RESULTS
The pathological response (tumor regression grade 0/1) in the P-SOX group was significantly higher than that in the SOX group (42.86% vs 18.03%, P = 0.013). The incidence of ypN0 in the P-SOX group was higher than that in the SOX group (39.29% vs 19.67%, P = 0.05). The use of PD-1 inhibitors was an independent factor affecting tumor regression grade. Meanwhile, the use of PD-1 did not increase postoperative complications or the adverse effects of NAT.
CONCLUSION
A PD-1 inhibitor combined with SOX could significantly improve the rate of tumour regression during NAT for patients with Borrmann large type III and IV GCs.
Two missense STK11 gene variations impaired LKB1/adenosine monophosphate-activated protein kinase signaling in Peutz-Jeghers syndrome
Authors: Liu Jin , Zeng Si-Cong , Wang An , Cheng Hai-Ying , Zhang Qian-Jun , Lu Guang-Xiu 
Published: April 2024

BACKGROUND
Peutz-Jeghers syndrome (PJS) is a rare hereditary neoplastic disorder mainly associated with serine/threonine kinase 11 (STK11 /LKB1 ) gene mutations. Preimplantation genetic testing can protect a patient’s offspring from mutated genes; however, some variations in this gene have been interpreted as variants of uncertain significance (VUS), which complicate reproductive decision-making in genetic counseling.
AIM
To identify the pathogenicity of two missense variants and provide clinical guidance.
METHODS
Whole exome gene sequencing and Sanger sequencing were performed on the peripheral blood of patients with PJS treated at the Reproductive and Genetic Hospital of Citic-Xiangya. Software was employed to predict the protein structure, conservation, and pathogenicity of the two missense variation sites in patients with PJS. Additionally, plasmids were constructed and transfected into HeLa cells to observe cell growth. The differences in signal pathway expression between the variant group and the wild-type group were compared using western blot and immunohistochemistry. Statistical analysis was performed using one-way analysis of variance. P < 0.05 was considered statistically significant.
RESULTS
We identified two missense STK11 gene VUS [c.889A>G (p.Arg297Gly) and c.733C>T (p.Leu245Phe)] in 9 unrelated PJS families who were seeking reproductive assistance. The two missense VUS were located in the catalytic domain of serine/threonine kinase, which is a key structure of the liver kinase B1 (LKB1) protein. In vitro experiments showed that the phosphorylation levels of adenosine monophosphate-activated protein kinase (AMPK) at Thr172 and LKB1 at Ser428 were significantly higher in transfected variation-type cells than in wild-type cells. In addition, the two missense STK11 variants promoted the proliferation of HeLa cells. Subsequent immunohistochemical analysis showed that phosphorylated-AMPK (Thr172) expression was significantly lower in gastric, colonic, and uterine polyps from PJS patients with missense variations than in non-PJS patients. Our findings indicate that these two missense STK11 variants are likely pathogenic and inactivate the STK11 gene, causing it to lose its function of regulating downstream phosphorylated-AMPK (Thr172), which may lead to the development of PJS. The identification of the pathogenic mutations in these two clinically characterized PJS patients has been helpful in guiding them toward the most appropriate mode of pregnancy assistance.
CONCLUSION
These two missense variants can be interpreted as likely pathogenic variants that mediated the onset of PJS in the two patients. These findings not only offer insights for clinical decision-making, but also serve as a foundation for further research and reanalysis of missense VUS in rare diseases.
Optimization of pharmaceutical care for children with diseases of the upper respiratory tract in outpatient polyclinic institutions
Authors: Nehoda T. S. , Tarasenko V. O. 
Published: April 2024

Introduction. The analysis of scientific and information materials has shown that the theoretical foundations and conceptual provisions of pharmaceutical management and pharmacoeconomic research have been developed in the works of domestic scientists. At the same time, research on optimization of pharmaceutical care for children in outpatient facilities is currently only fragmentary, and there is no systematic approach to solving this problem.
The aim of the study. On the basis of a systemic approach, form a system of research on the optimization of pharmaceutical care for children with ENT diseases in outpatient polyclinic institutions.
Materials and methods. The methodological basis is the approaches of modern management in the field of strategic management, pharmacoeconomics, approaches to the assessment of drug consumption, legislative and regulatory documents. The objects of the study were family outpatient clinics and children's outpatient polyclinic institutions in the city of Kyiv and the Kyiv region. The initial information was 390 outpatient charts of patients with ENT diseases aged 3 to 17 years for the period of 2022; 125 expert questionnaires of otolaryngologists; 50 questionnaires of a sociological survey of parents of patients with ENT diseases. The research used methods of logical, structural analysis, SWOT analysis, sociological methods (expert opinions, interactive survey, questionnaire).
Results. A methodical approach to conducting pharmacoeconomic studies of pharmaceutical care for children in outpatient clinics has been developed. For the first time, an original method of multi-aspect matrix analysis was proposed, which makes it possible to evaluate and multi-factorially position the medicinal products of the researched assortment in order to justify its inclusion in the assortment list for the treatment of a certain nosology in ambulatory polyclinic conditions.
Conclusions. The practical significance of the research results lies in the creation of a system of approaches to optimizing pharmaceutical care for children in outpatient settings at the territorial level.
Peran Car Free Day sebagai Strategi Peningkatan Usaha Mikro, Kecil, dan Menengah (UMKM) di Mojokerto
Authors: Syaifur Rizal M. Hasan , Sahri Mohamad Zahrudin 
Published: April 2024

Usaha Mikro, Kecil, dan Menengah (UMKM) menjadi pilar penting dalam mendorong pertumbuhan ekonomi yang inklusif dan berkelanjuatan. Pemberdayaan UMKM banyak bermunculan pada kegiatan Car Free Day di berbagai kota termasuk Mojokerto. Oleh karena itu, Car Free Day memiliki potensi dalam meningkatkan pendapatan UMKM. Penelitian ini merupakan jenis penelitian kualitatif dengan pendekatan deksriptif. Dalam pengumpulan data, penelitian ini menggunakan langkah observasi dan wawancara pelaku UMKM yang beroperasi pada kegiatan Car Free Day wilayah Mojokerto. Hasil penelitian menunjukkan bahwa Car Free Day dapat meningkatkan 2 kali lipat pendapatan para pelaku UMKM dan PKL dibandingkan beroperasi diluar kegiatan tersebut. Peningkatan pendapatan ini terjadi karena pengunjung yang ramai dalam kegiatan Car Free Day. Selanjutnya, harapan besar bagi para pelaku UMKM bahwa keberlangsungan kegiatan Car Free Day dapat dipertahankan bahkan diperluas titik-titik wilayah Mojokerto yang belum dijangkau.
G.I. SPASSKY - THE ETHNOGRAPHER OF THE KHAKASS PEOPLE
Authors: Чертыков В.К. 
Published: April 2024

В статье анализируется статья известного исследователя Сибири Г. И. Спасского «Народы, кочующие в верху реки Енисея». Эта работа внесла неоценимый вклад в становление хакасской этнографии в первой четверти XIX в. и стала ориентиром для последующих исследователей коренного населения Хакасско-Минусинского края.
The article considers the famous Siberian researcher G. I. Spassky's article "The nomadic peoples at the upper reaches of the Yenisei River". This work made an invaluable contribution to the formation of Khakass ethnography in the first quarter of the 19th century and became a reference point for subsequent researchers who study the indigenous population of the Khakass-Minusinsk Region.