bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Implications of Precordial ST‐segment Elevation in Acute Inferoposterior Myocardial Infarction Caused by Proximal Right Coronary Artery Occlusion
Authors: Jim Man‐Hong , On‐On Chan Annie , Wong Chun‐Pong , Yiu Kai‐Hang , Miu Raymond , Wai‐Luen Lee Stephen , Lau M.D. Chu‐Pak 
Published: August 2007

AbstractBackgroundThe clinical significance of inferior wall acute myocardial infarction (MI) with combined ST‐segment elevation in both anterior and inferior leads, compared with inferior leads alone, is unknown.HypothesisDespite having more leads with precordial ST‐segment elevation, these patients may have a better outcome due to less posterior involvement, which tends to drag down the precordial ST‐segment.MethodsA total of 158 postinferior MI patients with documented proximal right coronary artery occlusion were retrospectively studied. They were divided into three subgroups according to the magnitude of concurrent ST‐segment deviation in lead V2: Group A (n = 19) had ST‐segment elevation ≥ 2.0 mm; Group B (n = 74) had ST‐segment lay between + 2.0 mm and − 2.0 mm; and Group C (n = 65) had ST‐segment depression ≥ 2.0 mm. The clinical and electrocardiographic characteristics were then compared among these threes subgroups.ResultsThe baseline demography, prevalence of risk factors, and treatment received were of no difference among the subgroups. However, Group A patients had significantly lower peak creatinine phosphokinase level and more preserved left ventricular function than Group B and C. Moreover, they had lower total sum of inferior ST‐segment magnitude, less ST‐segment depression in V4‐6, and more ST‐segment elevation in V4R than Group C. Group C patients had highest in‐hospital and one‐year mortality although it did not reach statistical significance.ConclusionsPrecordial ST‐segment elevation in inferior wall acute MI was associated with smaller infarct size and better left ventricular function, probably secondary to occlusion of a less dominant RCA, which did not result in a significant posterior infarction. Copyright © 2007 Wiley Periodicals, Inc.
Applying content management to automated provenance capture
Authors: Schuchardt Karen L. , Gibson Tara , Stephan Eric , Chin George 
Published: August 2007

AbstractWorkflows and data pipelines are becoming increasingly valuable to computational and experimental sciences. These automated systems are capable of generating significantly more data within the same amount of time compared to their manual counterparts. Automatically capturing and recording data provenance and annotation as part of these workflows are critical for data management, verification, and dissemination. We have been prototyping a workflow provenance system, targeted at biological workflows, that extends our content management technologies and other open source tools. We applied this prototype to the provenance challenge to demonstrate an end‐to‐end system that supports dynamic provenance capture, persistent content management, and dynamic searches of both provenance and metadata. We describe our prototype, which extends the Kepler system for the execution environment, the Scientific Annotation Middleware (SAM) content management software for data services, and an existing HTTP‐based query protocol. Our implementation offers several unique capabilities, and through the use of standards, is able to provide access to the provenance record with a variety of commonly available client tools. Copyright © 2007 John Wiley & Sons, Ltd.
EphrinB1‐EphB signaling regulates thymocyte‐epithelium interactions involved in functional T cell development
Authors: Alfaro David , García‐Ceca José J. , Cejalvo Teresa , Jiménez Eva , Jenkinson Eric J. , Anderson Graham , Muñoz Juan J. , Zapata Agustín 
Published: August 2007

AbstractThe Eph and ephrin families are involved in numerous developmental processes. Recently, an increasing body of evidence has related these families with some aspects of T cell development. In the present study, we show that the addition of either EphB2‐Fc or ephrinB1‐Fc fusion proteins to fetal thymus organ cultures established from 17‐day‐old fetal mice decreases the numbers of both double‐positive (CD4+CD8+) and single‐positive (both CD4+CD8– and CD4–CD8+) thymocytes, in correlation with increased apoptosis. By using reaggregate thymus organ cultures formed by fetal thymic epithelial cells (TEC) and CD4+CD8+ thymocytes, we have also demonstrated that ephrinB1‐Fc proteins are able to disorganize the three‐dimensional epithelial network that in vivo supports the T cell maturation, and to alter the thymocyte interactions. In addition, in an in vitro model, Eph/ephrinB‐Fc treatment also decreases the formation of cell conjugates by CD4+CD8+ thymocytes and TEC as well as the TCR‐dependent signaling between both cell types. Finally, immobilized EphB2‐Fc and ephrinB1‐Fc modulate the anti‐CD3 antibody‐induced apoptosis of CD4+CD8+ thymocytes in a process dependent on concentration. These results therefore support a role for Eph/ephrinB in the processes of development and selection of thymocytes as well as in the establishment of the three‐dimensional organization of TEC.
Immune mechanisms leading to abnormal B cell selection and activation in New Zealand Black mice
Authors: Roy Valerie , Bonventi Gabriel , Cai Yongchun , MacLeod Ralph , Wither Joan E. 
Published: August 2007

AbstractPolyclonal B cell activation is a hallmark of the immune dysregulation in New Zealand Black (NZB) mice. We have previously shown that the splenic B cell activation is associated with increased CD80 expression. Here we show that abnormal expansions of CD80‐expressing GC, CD5+, marginal zone (MZ) precursor and MZ B cells produce this increase. To investigate the role of BCR engagement in the generation and activation of these populations, a non‐self‐reactive Ig Tg was introduced onto the NZB background. NZB Ig‐Tg mice lacked Tg CD5+ and peanut agglutinin+ B cells, confirming the role of endogenous Ag in their selection. Although the increased proportion of MZ B cells was retained in NZB Ig‐Tg mice, CD80 expression on these cells was reduced as compared to non‐Tg NZB mice, suggesting a role for BCR engagement with endogenous Ag in their activation. Examination of CD40L‐knockout NZB mice showed no difference in the abnormal activation or selection of the B cell populations, with the exception of GC cells, as compared to wild‐type NZB mice. Thus, polyclonal B cell activation in NZB mice does not require CD40 engagement, but results, in part, from dysregulated BCR‐specific mechanisms.
Square‐Wave Voltammetric Determination of Paraquat at Carbon Paste Electrode Modified with Hydroxyapatite
Authors: El Mhammedi Moulay Abderrahim , Bakasse Mina , Chtaini Abdelilah 
Published: August 2007

AbstractThe voltammetric behavior of paraquat was investigated at hydroxyapatite‐modified carbon paste electrode HAP‐CPE in K2SO4. A method was developed for the detection of the trace of this herbicide, based on their redox reaction. The reduction peaks of paraquat were observed around −0.70 V and −1.00 V (vs. SCE) in square‐wave voltammetry. Experimental conditions were optimized by varying the accumulation time, apatite loading and measuring solution pH. Calibration plots were linear under the optimized parameters over the herbicide's concentration range 8–200×10−7 mol L−1, with a detection and quantification limits about 1.5×10−8 mol L−1 and 6.4 10−8 mol L−1, respectively.
Fitting negative spatial covariances to geothermal field temperatures in Nea Kessani (Greece)
Authors: Mateu Jorge , Porcu Emilio , Christakos George , Bevilacqua Moreno 
Published: August 2007

AbstractIn this paper, we investigate the problem of negative empirical covariances for temperature data in a three‐dimensional geothermal field. We make use of permissibility criteria that allow a linear combination of covariance functions to be positive definite even if some of the weights of the linear combination are set to be negative. We thus propose a generalized sum of spatial covariance structures to model negative spatial covariances. We evaluate the performance of the proposed model, together with that of other celebrated, and widely used covariance functions. Comparison is done in terms of cross‐validation, which allows to evaluate the relative bias, accuracy of estimation, and goodness‐of‐fit. Copyright © 2007 John Wiley & Sons, Ltd.
Prediction of the force–drift envelope for RC columns in flexure by the CAE method
Authors: Peruš Iztok , Fajfar Peter 
Published: August 2007

AbstractA non‐parametric empirical approach, called the conditional average estimator (CAE) method, has been applied for the prediction of the normalized lateral force–drift envelope of reinforced concrete (RC) rectangular columns, as well as their characteristic drifts (effective yield drift, capping drift and ultimate drift), and drift‐related parameters (the ratio between the effective yield drift and elastic drift, and two ductility measures). A subset of the PEER RC column database was used. Five input parameters were employed: axial load index, index related to confinement, shear span index, concrete compressive strength, and longitudinal reinforcement index. The results suggest that the relations between the input and output parameters are complex, and that it is difficult to isolate the influence of a single parameter. Nevertheless, some trends were observed. The axial load index is the most influential input parameter. All the results decrease with an increasing axial load index, whereas they increase with an increasing longitudinal
reinforcement index. An increase in the index related to confinement results in increases in the ultimate drift and in ductility. The influence of the shear span index is the most complex. The influence of the concrete strength is small with the exception of two output parameters related to elastic drift, which substantially decrease with increasing strength. The dispersion of the results is relatively large. The results of the predictions can be used for mathematical modelling of moment–rotation backbone curves for plastic hinges, and for the estimation of the deformation capacity of columns in seismic performance assessments. Copyright © 2007 John Wiley & Sons, Ltd.
Homozygous deletion scanning of the lung cancer genome at a 100‐kb resolution
Authors: Nagayama Kazuhiro , Kohno Takashi , Sato Masanori , Arai Yasuhito , Minna John D. , Yokota Jun 
Published: August 2007

AbstractWhole genome scanning of 43 lung cancer cell lines at a 100‐kb resolution led to identification of 51 genomic regions with homozygous deletions (HDs). The regions contained 113 genes, including two known tumor suppressor genes, RBl (RB) and CDKN2A (p16), and eight genes previously reported as being candidate tumor suppressor genes, such as PTPRD and LRP1B. Three miRNA genes, MIRNLET7C (let‐7c), MIRN99A (hsa‐mir‐99a), and MIRN125B2 (hsa‐mir‐125b‐2), were also mapped in a region with HD at 21q11‐q21. The present study provides a list of protein‐ and miRNA‐encoding genes whose inactivation is possibly involved in lung carcinogenesis. © 2007 Wiley‐Liss, Inc.
Altering DNA base excision repair: Use of nuclear and mitochondrial‐targeted N‐methylpurine DNA glycosylase to sensitize astroglia to chemotherapeutic agents
Authors: Harrison Jason F. , Rinne Mikael L. , Kelley Mark R. , Druzhyna Nadiya M. , Wilson Glenn L. , Ledoux Susan P. 
Published: August 2007

AbstractPrimary astrocyte cultures were used to investigate the modulation of DNA repair as a tool for sensitizing astrocytes to genotoxic agents. Base excision repair (BER) is the principal mechanism by which mammalian cells repair alkylation damage to DNA and involves the processing of relatively nontoxic DNA adducts through a series of cytotoxic intermediates during the course of restoring normal DNA integrity. An adenoviral expression system was employed to target high levels of the BER pathway initiator, N‐methylpurine glycosylase (MPG), to either the mitochondria or nucleus of primary astrocytes to test the hypothesis that an alteration in BER results in increased alkylation sensitivity. Increasing MPG activity significantly increased BER kinetics in both the mitochondria and nuclei. Although modulating MPG activity in mitochondria appeared to have little effect on alkylation sensitivity, increased nuclear MPG activity resulted in cell death in astrocyte cultures treated with methylnitrosourea (MNU). Caspase‐3 cleavage was not detected, thus indicating that these alkylation sensitive astrocytes do not undergo a typical programmed cell death in response to MNU. Astrocytes were found to express relatively high levels of antiapoptotic Bcl‐2 and Bcl‐XL and very low levels of proapoptotic Bad and Bid suggesting that the mitochondrial pathway of apoptosis may be blocked making astrocytes less vulnerable to proapoptotic stimuli compared with other cell types. Consequently, this unique characteristic of astrocytes may be responsible, in part, for resistance of astrocytomas to chemotherapeutic agents. © 2007 Wiley‐Liss, Inc.
Task and semantic relationship influence both the polarity and localization of hemodynamic modulation during lexico‐semantic processing
Authors: Kuperberg Gina R. , Lakshmanan Balaji M. , Greve Douglas N. , West W. Caroline 
Published: August 2007

AbstractThis study examined how task (implicit vs. explicit) and semantic relationship (direct vs. indirect) modulated hemodynamic activity during lexico‐semantic processing. Participants viewed directly related, indirectly related, and unrelated prime‐target word‐pairs as they performed (a) an implicit lexical decision (LD) task in which they decided whether each target was a real word or a nonword, and (b) an explicit relatedness judgment (RJ) task in which they determined whether each word‐pair was related or unrelated in meaning. Task influenced both the polarity and neuroanatomical localization of hemodynamic modulation. Semantic relationship influenced the neuroanatomical localization of hemodynamic modulation. The implicit LD task was primarily associated with inferior prefrontal and ventral inferior temporal/fusiform hemodynamic response suppression to directly related (relative to unrelated) word‐pairs, and with more widespread temporal–occipital response suppression to indirectly related (relative to unrelated) word‐pairs. In contrast, the explicit RJ task was primarily associated with left inferior parietal hemodynamic response enhancement to both directly and indirectly related (relative to unrelated) word‐pairs, as well as with additional left inferior prefrontal hemodynamic response enhancement to indirectly related (relative to unrelated) word‐pairs. These findings are discussed in relation to the specific neurocognitive processes thought to underlie implicit and explicit semantic processes. Hum Brain Mapp, 2008. © 2007 Wiley‐Liss, Inc.
Increased neural efficiency in the temporal association cortex as the result of semantic task repetition
Authors: Whatmough Christine , Nikelski Jim , Monchi Oury , Chertkow Howard 
Published: August 2007

AbstractWe examined the effect of semantic task repetition and of alternating between tasks on cerebral blood flow in three H215O positron emission tomography experiments. We found that repeatedly performing semantic tasks resulted in a reduction in cerebral blood flow to the left temporal association cortex similar to that found in priming experiments even though here there was no repetition of stimuli. Although the same effect was found in two different tasks (word meaning judgments and picture naming), it was only present when the same task was repeated on consecutive scans and not when the subjects alternated from scan to scan between tasks. We propose that there is a neural efficiency which develops in the association cortex of the temporal lobe as a result of repeatedly performing a semantic task. This efficiency is abolished by interruptions such as performing a different task. Hum Brain Mapp, 2008. © 2007 Wiley‐Liss, Inc.
Erratum: Serotonin reuptake inhibitors in pregnancy and the risk of major malformations: a systematic review
Authors: Bellantuono Cesario , Migliarese Giovanni , Gentile Salvatore 
Published: August 2007

AbstractHum Psychopharmacol 2007; 22: 121–128. DOI: 10.1002/hup.836It has come to our attention that there was an error contained in the above article within the abstracts heading relating to Methods. The article stated that:‘A literature search was conducted within PsychoINFO’.This should have been published as:‘A literature search was conducted within PsycINFO’.We apologise for this anomaly.
Genetic polymorphisms and esophageal cancer risk
Authors: Hiyama Toru , Yoshihara Masaharu , Tanaka Shinji , Chayama Kazuaki 
Published: August 2007

AbstractThe aim of this paper is to review and evaluate, in a comprehensive manner, the published data regarding the contribution of genetic polymorphisms to risk of esophageal cancer, including squamous cell carcinoma (SCC) and adenocarcinoma, in humans. All relevant studies available in MEDLINE and published before February 2007 were identified. Studies carried out in humans and that compared esophageal cancer patients with at least 1 standard control group were considered for analysis. One‐hundred studies and 3 meta‐analyses were identified. Eighty (80%) studies were conducted in Asian countries, particularly China including Taiwan (60 (60%) studies). The most intensively examined genes were those encoding carcinogen metabolic enzymes. The most widely studied gene was GSTM1 (15 studies), followed by ALDH2 (11 studies). ALDH2, MTHFR C677T, CYP1A1 Ile/Val, CYP1A1MspI, CYP2E1, GSTP1, GSTM1 and GSTT1 were examined by meta‐analyses and significant relations were found between ALDH2*1*2 and the CYP1A1 Val allele and increased risk of esophageal cancer. In addition, increased risk of esophageal SCC was consistently associated with the ADH2*1*2 and the p53 codon 72 Pro/Pro genotypes. Cohort studies that simultaneously consider multiple genetic and environmental factors possibly involved in esophageal carcinogenesis are needed to ascertain not only the relative contribution of these factors to tumor development but also the contributions of their putative interactions. © 2007 Wiley‐Liss, Inc.
Integrating spirituality and psychotherapy: Ethical issues and principles to consider
Authors: Plante Thomas G. 
Published: August 2007

AbstractProfessional and scientific psychology appears to have rediscovered spirituality and religion during recent years, with a large number of conferences, seminars, workshops, books, and special issues in major professional journals on spirituality and psychology integration. The purpose of this commentary is to highlight some of the more compelling ethical principles and issues to consider in spirituality and psychology integration with a focus on psychotherapy. This commentary will use the American Psychological Association's (2002) Ethics Code and more specifically, the RRICC model of ethics that readily applies to various mental health ethics codes across the world. The RRICC model highlights the ethical values of respect, responsibility, integrity, competence, and concern. Being thoughtful about ethical principles and possible dilemmas as well as getting appropriate training and ongoing consultation can greatly help the professional better navigate these challenging waters. © 2007 Wiley Periodicals, Inc. J Clin Psychol 63: 891–902, 2007.
Does integrated trauma‐informed substance abuse treatment increase treatment retention?
Authors: Amaro Hortensia , Chernoff Miriam , Brown Vivian , Arévalo Sandra , Gatz Margaret 
Published: August 2007

AbstractThis article presents findings from a quasi‐experimental, nonrandomized group design study that explored whether trauma‐enhanced substance abuse treatment results in longer residential treatment stays and improved outcomes compared with treatment‐as‐usual. We used a subsample (N = 461) of participants in the Women, Co‐Occurring Disorders and Violence Study, which was sponsored by the Substance Abuse and Mental Health Services Administration. The intervention group was 31% less likely to discontinue treatment within 4 months. Baseline mental health and trauma symptoms and alcohol and drug severity scores predicted neither overall length of time in treatment nor differences in retention between intervention and comparison groups. Substance abuse and mental health symptoms improved with increased duration of treatment, particularly for women with more severe baseline symptoms. © 2007 Wiley Periodicals, Inc. J Comm Psychol 35: 845–862, 2007.
Small RNAs: Regulators and guardians of the genome
Authors: Chu Chia‐Ying , Rana Tariq M. 
Published: August 2007

AbstractSmall non‐coding RNAs comprise several classes and sizes, but all share a unifying function in cellular physiology: epigenetic regulation of gene expression. Here, we review the salient aspects of recent studies on the biogenesis and function of three classes of small RNAs: miRNAs, siRNAs, and piRNAs. Although the mechanisms are becoming clear by which siRNA‐triggered mRNA cleavage silences genes, more studies are needed on several issues regarding miRNA‐mediated translation repression. Piwi proteins have been suggested to co‐operate in amplifying piRNA biogenesis to maintain transposon silencing in the germ line genome, but details of this process are still unknown as well as the functional consequences of piRNA expression at discrete genomic loci. J. Cell. Physiol. 213: 412–419, 2007. © 2007 Wiley‐Liss, Inc.
Preparation of [11C]methyl nona‐fluorobutyl‐1‐sulfonate ([11C]MeONf) and its use in the synthesis of [11C]‐6‐OH‐BTA‐1
Authors: Jolly Dean , Lakhrissi Younes , Kovacevic Miriam M. , Chertkow Howard , Schirrmacher Ralf 
Published: August 2007

AbstractThe rapid, simple and high‐yield synthesis of the extraordinarily reactive 11C‐methylating agent, [11C]methyl nona‐fluorobutyl‐1‐sulfonate ([11C]MeONf), and its use in the synthesis of the promising β‐amyloid imaging agent, [11C]‐6‐OH‐BTA‐1, is reported. In terms of radioactive methylation yields, [11C]MeONf seems to surpass [11C]methyl trifluoromethansulfonate ([11C]MeOTf) as a methylating agent in this particular case giving the 11C‐labelled compound in high‐preparative radiochemical yields between 27 and 29% EOS with a minimum formation of radioactive by‐products. Copyright © 2007 John Wiley & Sons, Ltd.
Measurement equivalence of executives' performance ratings for same‐ and opposite‐gender dyads
Authors: Etchegaray Jason M. 
Published: August 2007

AbstractThe measurement equivalence of performance ratings from different raters is important to establish if researchers and practitioners want to have confidence that raters are using the performance measurement system in the same way. The purpose of the present study was to examine the measurement equivalence of performance ratings from male and female direct reports. Women and men executives from various organizations participated in a multisource assessment process for feedback and development purposes and were rated by both women and men direct reports. The results indicated gender equivalence for direct reports' ratings of men and women executives, meaning that regardless of gender, raters provided ratings using the same psychological metric. The implications and limitations of the study are discussed.