bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Aerogel Materials from Marine Polysaccharides
Authors: Quignard Francoise , Valentin Romain , Di Renzo Francesco 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Reactivity of Surface Alkoxy Species on Acidic Zeolite Catalysts
Authors: Wang Wei , Hunger Michael 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Ylide‐Initiated Michael Addition—Cyclization Reactions Beyond Cyclopropanes
Authors: Sun Xiu‐Li , Tang Yong 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Using Singlet Oxygen to Synthesize Polyoxygenated Natural Products from Furans
Authors: Montagnon Tamsyn , Tofi Maria , Vassilikogiannakis Georgios 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Direct Functionalization of Nitrogen Heterocycles via Rh‐Catalyzed C—H Bond Activation
Authors: Lewis Jared C. , Bergman Robert G. , Ellman Jonathan A. 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Marine Drugs — Macrolactins
Authors: Lu Xiao‐Ling , Xu Qiang‐Zhi , Liu Xiao‐Yu , Cao Xin , Ni Kun‐Yi , Jiao Bing‐Hua 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Compounds from Viburnum Species and Their Biological Activities
Authors: Wang Li‐Qin , Chen Ye‐Gao , Xu Jun‐Ju , Liu Ying , Li Xiao‐Mei , Zhao Yan 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Gel‐integrated Voltammetric Microsensors and Submersible Probes as Reliable Tools for Environmental Trace Metal Analysis and Speciation
Authors: Tercier‐Waeber Mary‐Lou , Confalonieri Fabio , Koudelka‐Hep Milena , Dessureault‐Rompre Jacynthe , Graziottin Flavio , Buffle Jacques 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Untersuchungen zur Adsorption von n‐Butan an Aktivkohle
Authors: Hücker V. , Vogel H. 
Published: November 2008

AbstractDie zunehmende Zahl von Fahrzeugen im Straßenverkehr und ein gestiegenes Umwelt‐ und Gesundheitsbewusstsein der Menschen macht den adsorptiven Autoinnenraum‐Zuluftfilter zu einem unverzichtbaren Bestandteil des modernen Kraftfahrzeugs. Wichtig für die Weiterentwicklung dieser Filtermedien ist ein besseres Verständnis der Ad‐ und Desorptionseigenschaften der darin verwendeten Aktivkohle, insbesondere im umweltrelevanten Konzentrationsbereich.
Thermogravimetrische Untersuchungen zur Pyrolyse von Ölpalmschalen
Authors: Gómez A. , Klose W. , Rincón S. 
Published: November 2008

AbstractDie Einflüsse der Prozessparameter auf den Ablauf der Pyrolysereaktionen und die Verteilung der Produkte Pyrolysat, Flüssigkeit und Gas bei der Pyrolyse von Ölpalmschalen wird durch thermogravimetrische Untersuchungen bestimmt. Diese Untersuchungen erlauben es, Versuchsbedingungen zu ermitteln, bei denen die Pyrolyse im chemisch bestimmten Bereich abläuft.
Phosphorylation of tropomyosin extends cooperative binding of myosin beyond a single regulatory unit
Authors: Rao Vijay S. , Marongelli Ellisha N. , Guilford William H. 
Published: November 2008

AbstractTropomyosin (Tm) is one of the major phosphoproteins comprising the thin filament of muscle. However, the specific role of Tm phosphorylation in modulating the mechanics of actomyosin interaction has not been determined. Here we show that Tm phosphorylation is necessary for long‐range cooperative activation of myosin binding. We used a novel optical trapping assay to measure the isometric stall force of an ensemble of myosin molecules moving actin filaments reconstituted with either natively phosphorylated or dephosphorylated Tm. The data show that the thin filament is cooperatively activated by myosin across regulatory units when Tm is phosphorylated. When Tm is dephosphorylated, this “long‐range” cooperative activation is lost and the filament behaves identically to bare actin filaments. However, these effects are not due to dissociation of dephosphorylated Tm from the reconstituted thin filament. The data suggest that end‐to‐end interactions of adjacent Tm molecules are strengthened when Tm is phosphorylated, and that phosphorylation is thus essential for long range cooperative activation along the thin filament. Cell Motil. Cytoskeleton 2008. © 2008 Wiley‐Liss, Inc.
Guanidinylated Dendritic Molecular Transporters: Prospective Drug Delivery Systems and Application in Cell Transfection
Authors: Theodossiou T. A. , Pantos A. , Tsogas I. , Paleos C. M. 
Published: November 2008

AbstractIn the present review the crucial role of the guanidinium functional group in facilitating the transport of dendritic polymers through liposomal and cell membranes is discussed, along with other structural features of guanidinylated dendritic polymers that fine‐tune their transport properties, and even determine their subcellular destinations. In this context, an ideal dendritic molecular transporter would need to possess a dendritic scaffold of the appropriate size and degree of guanidinylation, flexibility of the guanidinium moiety, and should exhibit a proper balance between hydrophilic and hydrophobic moieties located on the dendritic surface. All of the above are illustrated through selected paradigms from the relevant literature, which give a valuable insight into forging successful dendritic delivery systems for both drugs and genes. The main challenge for the future focus of the field is identified as the determination of the key structural and functional characteristics that will enhance cell internalisation, and secure localisation in specific subcellular organelles.
Discovery of Novel Anticancer Compounds Based on a Quinoxalinehydrazine Pharmacophore
Authors: Deng Jinxia , Taheri Laleh , Grande Fedora , Aiello Francesca , Garofalo Antonio , Neamati Nouri 
Published: November 2008

AbstractQuinoxalinehydrazines represent a novel class of compounds with excellent potency in a panel of cancer cell lines. A prototype compound, SC144, showed significant in vivo efficacy in mice xenograft models of human breast cancer cells. The subsequent structure–activity relationship study resulted in the discovery of SC161 with better potency in cancer cell lines. Further exploring the possible conformational space by a 10 ns molecular dynamics simulation as presented herein, resulted in various pharmacophore orientations. The trajectory analysis indicated that in most of the simulation time, the molecule stays favorably in a compact planarlike orientation. We therefore built a pharmacophore model based on the cluster containing the highest number of frames to represent the most probable orientation. The model was used to screen a subset of our small molecule database containing 350,000 compounds. We selected 35 compounds for the initial cytotoxicity screen. Seventeen compounds belonging to oxadiazolopyrazine and quinoline class displayed cytotoxicity in various cancer cell lines. Five of them, compounds 2, 6, 15, 16, and 19, all bearing an oxadiazolopyrazine scaffold, showed IC50 values <3 μM in certain tumor cell lines. The most potent compound, 2, showed IC50 values <2 μM in HCT116 p53+/+, HCT116 p53−/−, and HEY cells, and 8 μM in NIH3T3 cells. This study shows that conformational sampling of a lead small molecule followed by representative pharmacophore model development is an efficient approach for the rational design of novel anticancer agents with similar or better potency than the original lead but with different physicochemical properties.
Hyalinizing clear cell carcinoma
Authors: Solar Antonieta A. , Schmidt Brian L. , Jordan Richard C. K. 
Published: November 2008

AbstractBACKGROUD:Hyalinizing clear cell carcinoma (HCCC) is an uncommon malignant salivary gland tumor that was characterized only recently as a distinct entity. Because of its histologic similarity to several other primary and metastatic tumors and its purported favorable clinical outcome after local resection, it is important to recognize the features of this unusual tumor.METHODS:The authors present 8 new, fully characterized cases of HCCC and systematically reviewed 44 other cases of HCCC reported in the English language literature from 1980 to 2008. Historic cases were reviewed, and available data regarding morphology, special stains, demographics, clinical presentation, radiographic findings, management, and outcomes were extracted. Data from the current series were compared with the earlier published literature.RESULTS:To the best of the authors' knowledge, this was the largest reviewed series of HCCC and included a total of 52 cases. The findings, which included key histologic features, clinical presentation, and outcome, generally were consistent with what was reported previously. However, the current review revealed that 25% of patients reported in the literature had metastatases at initial presentation, including 10 of 44 patients who had metastases to regional lymph nodes and 1 patient who had metastasis to the lung. The authors were unable to identify any specific histologic features that would predict this behavior.CONCLUSIONS:The current results indicated that HCCC is less indolent than was believed previously; therefore, regional lymph node dissection should be considered in conjunction with wide local excision for patients with HCC. Cancer 2009. © 2008 American Cancer Society.
Mechanism of aggregation and intergrowth of crystals during bulk crystallization from solutions
Authors: Linnikov O. D. 
Published: November 2008

AbstractAvailable literature data on aggregation kinetics of crystals of a number of salts during their bulk crystallization from solutions have been analysed. The proposed earlier mechanism of aggregation and intergrowth of crystals during bulk crystallization owing to formation of nucleus‐bridges between crystals was tested and confirmed. The aggregation kinetics of crystals was described by the familiar Smoluchowski equation for coagulation of colloidal particles. However, in a bulk crystallization process, the aggregation constant in this equation decreased as supersaturation in a solution lowered. An expression for the aggregation constant in this equation was proposed. The proposed mechanism of crystal intergrowth duringt bulk crystallization allowed evaluating the specific surface energy of tested salts, which turned out to be in reasonable agreement with published literature data. It was concluded that the intergrowth of crystals during bulk crystallization from solutions proceeded via formation of nucleus‐bridges between crystals. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Liquid phase epitaxy set‐up designed for in situ X‐ray study of SiGe island growth on (001) Si substrates
Authors: Teubner Th. , Jendritzki U. , Böttcher K. , Schadow G. , Heimburger R. , Gerlitzke A.‐K. , Deiter S. , Eisenschmidt Ch. , Boeck T. , Fornari R. , Hanke M. 
Published: November 2008

AbstractIn situ X‐ray examination at a synchrotron beamline of the solution growth of self‐assembled SiGe structures on silicon (001) substrates through the backside has been realized by a specific heating equipment and a suitable growth assembly. The furnace allows heating of the growth assembly up to 600 °C. The temperature field and the gas flow in the furnace have been numerically modeled. In this way a meaningful estimate about the power consumption and the thermal gradient across the sample has been reached. Despite its low heat capacity and, thus, fast heating and cooling ability the furnace can be stabilized to ± 0.1 K by a high‐performance temperature controller. The growth assembly has been prepared within three separate stages carried out in conventional slideboat liquid phase epitaxy equipment. Such growth assembly allows carrying out then intended experiments without H2 as normally used in liquid phase epitaxy in favor of N2, meeting the demand of minimized risks at beamlines. The equipment ensures an easy handling of the growth assembly. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Kinetic studies on the influence of temperature and growth rate history on crystal growth
Authors: Martins P. M. , Rocha F. A. 
Published: November 2008

AbstractCrystallization experiments of sucrose were performed in a batch crystallizer to study the effect of temperature and growth rate history on the crystal growth kinetics. In one of the growth methods adopted, the isothermal volumetric growth rate (RV) is determined as a function of supersaturation (S) at 35, 40 and 45 ºC. In the other, crystals are allowed to grow at constant supersaturation by automatically controlling the solution temperature as the solute concentration decreased. Using the latter method RV is calculated as the solution is cooled. The obtained results are interpreted using empirical, engineering and fundamental perspectives of crystal growth. Firstly, the overall activation energy (EA) is determined from the empirical growth constants obtained in the isothermal method. The concept of falsified kinetics, widely used in chemical reaction engineering, is then extended to the crystal growth of sucrose in order to estimate the true activation energy (ET) from the diffusion‐affected constant, EA. The differences found in the isothermal and constant supersaturation methods are explained from the viewpoint of the spiral nucleation mechanism, taking into account different crystal surface properties caused by the growth rate history in each method. Finally, the crystal growth curve obtained in the batch crystallizer at 40 ºC is compared with the one obtained in a fluidized bed crystallizer at the same temperature. Apparently divergent results are explained by the effects of crystal size, hydrodynamic conditions and growth rate history on the crystallization kinetics of sucrose. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
A decreased positivity for CD90 on human mesenchymal stromal cells (MSCs) is associated with a loss of immunosuppressive activity by MSCs
Authors: Campioni Diana , Rizzo Roberta , Stignani Marina , Melchiorri Loredana , Ferrari Luisa , Moretti Sabrina , Russo Antonio , Bagnara Gian Paolo , Bonsi Laura , Alviano Francesco , Lanzoni Giacomo , Cuneo Antonio , Baricordi Olavio R. , Lanza Francesco 
Published: November 2008

AbstractBiologic and clinical interest in human mesenchymal stromal cells (hMSC) has risen over the last years, mainly due to their immunosuppressive properties. In this study, we investigated the basis of immunomodulant possible variability using hMSC from different sources (amniotic membrane, chorion, and bone marrow from either healthy subjects or patients with hematological malignancies, HM) and having discordant positivity for several immunological markers. The CD90+ hMSC reduced lymphoproliferative response in phytohemagglutinin (PHA) activated peripheral blood mononuclear cells (PBMC) via sHLA‐G and IL‐10 up‐modulation. On the contrary, hMSC showing a significantly lower expression for CD90 antigen, elicited a lymphoproliferative allogeneic response in PHA/PBMCs without any increase in soluble HLA‐G and IL‐10 levels. These data seems to suggest that CD90 molecule may be considered a novel predictive marker for hMSC inhibitory ability, and might cooperate with HLA‐G molecule in regulating suppressive versus stimulatory properties of hMSC. These results may have clinical implication in either transplantation or in regenerative medicine fields. © 2008 Clinical Cytometry Society
The absolute counting of red cell‐derived microparticles with red cell bead by flow rate based assay
Authors: Nantakomol Duangdao , Imwong Malika , Soontarawirat Ingfar , Kotjanya Duangporn , Khakhai Chulalak , Ohashi Jun , Nuchnoi Pornlada 
Published: November 2008

AbstractBackground:Activation of red blood cell is associated with the formation of red cell‐derived microparticles (RMPs). Analysis of circulating RMPs is becoming more refined and clinically useful. A quantitative Trucount™ tube method is the conventional method uses for quantitating RMPs. In this study, we validated a quantitative method called “flow rate based assay using red cell bead (FCB)” to measure circulating RMPs in the peripheral blood of healthy subjects.Methods:Citrated blood samples collected from 30 cases of healthy subjects were determined the RMPs count by using double labeling of annexin V‐FITC and anti‐glycophorin A‐PE. The absolute RMPs numbers were measured by FCB, and the results were compared with the Trucount™ or with flow rate based calibration (FR). Statistical correlation and agreement were analyzed using linear regression and Bland‐Altman analysis.Results:There was no significant difference in the absolute number of RMPs quantitated by FCB when compared with those two reference methods including the Trucount™ tube and FR method. The absolute RMPs count obtained from FCB method was highly correlated with those obtained from Trucount™ tube (r2 = 0.98, mean bias 4 cell/μl, limit of agreement [LOA] −20.3 to 28.3 cell/μl), and FR method (r2 = 1, mean bias 10.3 cell/μl, and LOA −5.5 to 26.2 cell/μl).Conclusion:This study demonstrates that FCB is suitable and more affordable for RMPs quantitation in the clinical samples. This method is a low cost and interchangeable to latex bead‐based method for generating the absolute counts in the resource‐limited areas. © 2008 Clinical Cytometry Society
The migratory behavior of immature enteric neurons
Authors: Hao M.M. , Anderson R.B. , Kobayashi K. , Whitington P.M. , Young H.M. 
Published: November 2008

AbstractWhile they are migrating caudally along the developing gut, around 10%–20% of enteric neural crest‐derived cells start to express pan‐neuronal markers and tyrosine hydroxylase (TH). We used explants of gut from embryonic TH‐green fluorescence protein (GFP) mice and time‐lapse microscopy to examine whether these immature enteric neurons migrate and their mode of migration. In the gut of E10.5 and E11.5 TH‐GFP mice, around 50% of immature enteric neurons (GFP+ cells) migrated, with an average speed of around 15 μm/h. This is slower than the speed at which the population of enteric neural crest‐derived cells advances along the developing gut, and hence neuronal differentiation seems to slow, but not necessarily halt, the caudal migration of enteric neural crest cells. Most migrating immature enteric neurons migrated caudally by extending a long‐leading process followed by translocation of the cell body. This mode of migration is different from that of non‐neuronal enteric neural crest‐derived cells and neural crest cells in other locations, but resembles that of migrating neurons in many regions of the developing central nervous system (CNS). In migrating immature enteric neurons, a swelling often preceded the movement of the nucleus in the direction of the leading process. However, the centrosomal marker, pericentrin, was not localized to either the leading process or swelling. This seems to be the first detailed report of neuronal migration in the developing mammalian peripheral nervous system. © 2008 Wiley Periodicals, Inc. Develop Neurobiol, 2009.
FGFR2 in the dental epithelium is essential for development and maintenance of the maxillary cervical loop, a stem cell niche in mouse incisors
Authors: Lin Yongshun , Cheng Yi‐Shing Lisa , Qin Chunlin , Lin Chunhong , D'Souza Rena , Wang Fen 
Published: November 2008

AbstractConstant supplies of dental epithelial cells from stem cell niches in the cervical loop enable mouse incisors to grow continuously through life. Fibroblast growth factor 10 (FGF10) has been shown to be essential for development of mouse incisors and maintenance of incisor cervical loops during prenatal development. Whether its cognate receptor, FGFR2IIIB, in the dental epithelium is required for postnatal tooth development remains unknown because Fgfr2IIIb ablation causes neonatal lethality. Here we report that tissue‐specific ablation of Fgfr2 in the dental epithelium led to defective maxillary incisors that lacked ameloblasts and the enamel, and had poorly developed odontoblasts. Although the cervical loop in Fgfr2 null maxillary incisors was formed initially, it failed to continue to develop and gradually diminished soon after birth. The results suggest that the FGFR2 signaling axis plays a role in maintaining the stem cell niche required for incisor development and lifelong growth. Developmental Dynamics 238:324–330, 2009. © 2008 Wiley‐Liss, Inc.