bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predicting Generation Z consumers’ food waste reduction behavior through social media marketing activities: a mediated model
Authors: Attiq Saman , Mumtaz Sumia , Abbasi Amir Zaib , Bashir Shahid 
Published: March 2024

PurposeThe present study aims to examine the impact of social media marketing activities (SMMAs) on the adoption of food waste reduction behavior among Generation Z consumers within the restaurant service industry in Pakistan. The study focuses on the impact of social media advertisements and investigates the mediating influence of waste reduction intentions on actual behavior. This underscores the significance of contextual and emotional variables in comprehending consumer behaviors.Design/methodology/approachThe study used a cross-sectional research methodology to examine the impact of SMMAs on the behavior of Generation Z consumers in Pakistan’s food service industry with regard to reducing food waste. A study was conducted to investigate the restaurant purchasing behaviors of a sample consisting of 449 individuals belonging to the millennial generation, often known as Generation Z.FindingsThe majority of variables related to SMMA, except for interactivity and personalization, were shown to have a positive impact on individuals’ intents to reduce food waste. The study observed a significant relationship between consumers’ intentions to decrease waste and their actual behavior in waste reduction. Furthermore, this relationship was shown to be influenced by the mediating role of waste reduction intention.Originality/valueExamining how social media affects Pakistani Generation Z’s efforts to reduce food waste is what makes this study distinctive. According to the research, the majority of social media factors positively influence intentions to reduce waste. The relationship between intentions and actual behavior, which highlights the impact of social media campaigns and emotional aspects in promoting waste reduction, is one of the important conclusions.
Clarifying the definition of common mycorrhizal networks
Authors: Rillig Matthias C. , Lehmann Anika , Lanfranco Luisa , Caruso Tancredi , Johnson David 
Published: March 2024

Abstract

Common mycorrhizal networks (CMNs) are an enigmatic feature of soil and mycorrhizal ecology. The current use of the term ‘common mycorrhizal network’ stipulates a direct, continuous physical link between plants formed by the mycelium of mycorrhizal fungal genets. This means that a specific case (involving hyphal continuity) is used to define a much broader phenomenon of hyphae interlinking among roots of different plants.

We here embrace a more inclusive definition of the CMN as a network formed by mycorrhizal fungal genets among roots of different plants, irrespective of the type of connection or interaction, and not limited to direct hyphal linkages. Implicitly, this broader version of the term has been used by many researchers already.

We propose using the term ‘common mycorrhizal networks with hyphal continuity’ (CMN‐HC) to capture the more specific case of a continuous link via hyphae between the roots of different plants, which is important to study for some (notable carbon and nutrient exchange), but not all functions of a CMN (e.g. transfer of infochemicals or microbes).

In addition, and becoming more general than CMN, we introduce the term ‘common fungal network’ (CFN) to include networks of any type of connection formed between different plants by any type of fungus; this includes also non‐mycorrhizal fungi, and indeed a combination of non‐mycorrhizal and mycorrhizal networks.

We assert that this new conceptual framework incorporating three hierarchical terms (CMN‐HC, CMN and CFN), ranging from the most specific to the very broad, can usher in a period of new research activity on fungal networks.

Read the free Plain Language Summary for this article on the Journal blog.
Effect of aspirin on cardiovascular events in patients undergoing hemodialysis with hyperphosphatemia: A post hoc analysis of the LANDMARK trial
Authors: Kato Masanori , Ito Hidetoshi , Yamakawa Akane , Kagimura Tatsuo , Fukagawa Masafumi , Yamamoto Masahiro , Saito Yoshinori , Akizawa Tadao , Ogata Hiroaki 
Published: March 2024

AbstractIntroductionThe clinical benefits of aspirin in patients undergoing hemodialysis remain unclear.MethodsThe secondary analysis of the LANDMARK trial investigated whether aspirin use was associated with cardiovascular events (CVEs) and all‐cause mortality was performed. A total of 2135 patients at risk for vascular calcification were analyzed using a Cox proportional hazards model with propensity score matching.ResultsThe risk of CVEs was comparable between participants with aspirin use at baseline and those without at baseline, between participants with aspirin use during the study period and those without during the study period, and between participants with new aspirin prescription and those without aspirin use during the study period.ConclusionAspirin use was not significantly associated with a lower risk of CVEs in participants undergoing hemodialysis patients at risk of vascular calcification.
Food insecurity in adults with severe mental illness living in Northern England: A co‐produced cross‐sectional study
Authors: Smith Jo , Eskandari Fatemeh , McGeechan Grant J. , Teasdale Scott B. , Lake Amelia A. , Ker Suzy , Williamson Kevin , Augustine Alex , Sauvage Nikita Le , Lynch Chris , Moore Hannah , Scott Steph , Ekers David , Whittaker Vicki , Robinson Jonathan , Giles Emma L. 
Published: March 2024

AbstractAimThis study aimed to explore food insecurity prevalence and experiences of adults with severe mental illness living in Northern England.MethodsThis mixed‐methods cross‐sectional study took place between March and October 2022. Participants were adults with self‐reported severe mental illness living in Northern England. The survey included demographic, health, and financial questions. Food insecurity was measured using the US Department of Agriculture Adult Food Security measure. Quantitative data were analysed using descriptive statistics and binary logistic regression; and qualitative data using content analysis.ResultsIn total, 135 participants completed the survey, with a mean age of 44.7 years (SD: 14.1, range: 18–75 years). Participants were predominantly male (53.3%), white (88%) and from Yorkshire (50.4%). The food insecurity prevalence was 50.4% (n = 68). There was statistical significance in food insecurity status by region (p = 0.001); impacts of severe mental illness on activities of daily living (p = 0.02); and the Covid pandemic on food access (p < 0.001). The North West had the highest prevalence of food insecurity (73.3%); followed by the Humber and North East regions (66.7%); and Yorkshire (33.8%). In multivariable binary logistic regression, severe mental illness' impact on daily living was the only predictive variable for food insecurity (odds ratio = 4.618, 95% confidence interval: 1.071–19.924, p = 0.04).ConclusionThe prevalence of food insecurity in this study is higher than is reported in similar studies (41%). Mental health practitioners should routinely assess and monitor food insecurity in people living with severe mental illness. Further research should focus on food insecurity interventions in this population.
Oligarchy in professional accounting bodies: Challenges for governance and leader‐member relations
Authors: Clune Conor , Andon Paul 
Published: March 2024

AbstractDrawing on Robert Michels's “iron law” of oligarchy, this study examines a governance crisis that unfolded at one of the world's largest professional accounting bodies (PABs)—CPA Australia. We leverage Michels's century‐old contribution to the social sciences to explore how this crisis sheds light on the challenges that PAB governance arrangements can pose when PAB leadership and membership priorities conflict. By applying Michels's seminal work to theorize the origins, escalation, leadership collapse, and eventual resolution of this PAB governance crisis, we illuminate how governance arrangements fueled conflict and fostered a democratic deficit that frustrated sections of the membership in their attempts to debate issues, exercise accountability on leadership matters, and become involved in governance reform. Overall, our analysis reveals that despite espoused principles of equity and participation, PABs are vulnerable to oligarchy impacting how their leaders relate to the interests of their members. Implications for the capacity of PABs to accommodate member conflict and for member participation in the current‐day professional context are discussed.
Martius flaps for low rectovaginal fistulae: a systematic review and proportional meta‐analysis
Authors: Swindon Daisy , Izwan Sara , Ng Justin , Chan Erick , Abbas Naveed , Von Papen Michael , Sahebally Shaheel Mohammad 
Published: March 2024

AbstractBackgroundRectovaginal fistulae (RVF) are notoriously challenging to treat. Martius flap (MF) is a technique employed to manage RVF, among various others, with none being universally successful. We aimed to assess the outcomes of RVF managed with MF interposition.MethodsA PRISMA‐compliant meta‐analysis searching for all studies specifically reporting on the outcomes of MF for RVF was performed. The primary objective was the mean success rate, whilst secondary objectives included complications and recurrence. The MedCalc software (version 20.118) was used to conduct proportional meta‐analyses of data. Weighted mean values with 95% CI are presented and stratified according to aetiology where possible.ResultsTwelve non‐randomized (11 retrospective, 1 prospective) studies, assessing 137 MF were included. The mean age of the study population was 42.4 (±15.7), years. There were 44 primary and 93 recurrent RVF. The weighted mean success rate for MF when performed for primary RVF was 91.4% (95% CI: 79.45–98.46; I2 = 32.1%; P = 0.183) and that for recurrent RVF was 77.5% (95% CI: 62.24–89.67; I2 = 58.1%; P = 0.008). The weighted mean complication rate was 29% (95% CI: 8.98–54.68; I2 = 85.4%; P < 0.0001) and the overall recurrence rate was 12.0% (95% CI: 5.03–21.93; I2 = 52.3%; P = 0.021). When purely radiotherapy‐induced RVF were evaluated, the mean overall success rate was 94.6% (95% CI: 83.33–99.75; I2 = 0%; P = 0.350).ConclusionsMF interposition appears to be more effective for primary than recurrent RVF. However, the poor quality of the data limits definitive conclusions being drawn and demands further assessment with randomized studies.
The role of multiple high‐risk human papillomavirus infection on the persistence recurrence of high‐grade cervical lesions after standard treatment: A systematic review and a meta‐analysis
Authors: Cassani Chiara , Dominoni Mattia , Pasquali Marianna Francesca , Gardella Barbara , Spinillo Arsenio 
Published: March 2024

AbstractIntroductionThe role of multiple high‐risk human papillomavirus (HR‐HPV) infections on the occurrence of persistence/recurrence of high‐grade squamous intraepithelial lesion (HSIL) after conization/surgery for cervical intraepithelial neoplasia was evaluated.Material and methodsA systematic search of Pubmed/Medine, Scopus, Cochrane databases from inception to June 30, 2023 was performed. Three reviewers independently screened the abstracts of the selected studies and extracted data from full‐text articles. The data were subsequently tabulated and compared for consistency. The bias associated with each included study was evaluated according to the OSQE method. PROSPERO registration number CRD42023433022.ResultsOut of 1606 records screened, 22 full text articles met the inclusion criteria. A total of 8321 subjects treated (loop electrosurgical excision, laser or surgery) because of HSIL were followed‐up and included in the meta‐analysis. The pooled prevalence of overall persistence and/or recurrence was 17.6 (95% CI: 12.3–23.5) in multiple and 14.3 (95% CI: 10.1–19.2) in single HR‐HPV infections detected shortly before or at surgery. The pooled rate of multiple HR‐HPV infections was 25% (95% CI: 20.4–30). The odds ratio of histologically confirmed HSIL persistence and/or recurrence was significantly higher (OR: 1.38, 95% CI:1.08–1.75, p = 0.01, heterogeneity = 39%) among multiple than single HR‐HPV infections. Increased risk of HSIL persistence/recurrence was more marked among studies with multiple HR‐HPVs prevalence ≥25% (12 studies, N = 3476) (OR: 1.47, 95% CI: 1.18–1.84, heterogeneity = 0%) and in those evaluating true histologically confirmed recurrence after at least 6 months of negative follow‐up (9 studies, N = 5073) (OR: 1.67, 95% CI: 1.17–2.37, heterogeneity = 37%). Multiple HR‐HPVs infection detected during follow‐up visits had no effect on the risk of recurrence although the number of included studies was small (4 studies, N = 1248) (OR: 0.98, 95% CI: 0.68–1.39, heterogeneity = 0%). The risk of bias was rated as high in 10 and low‐moderate in 12 studies, respectively. In subgroup analysis, the risk of bias of the included studies (low/moderate vs. high), had a small, although not significant effect on the odds ratios of persistence/recurrence of HSIL (OR: 1.57, 95% CI: 1.23–2 for low‐moderate risk of bias and OR: 1.06, 95% CI: 0.65–1.75 for high risk of bias; p‐value for subgroup differences = 0.17).ConclusionsMultiple HR‐HPVs infections at the time of standard treatment of HSIL entail a small but significant increased risk of persistence/recurrence of HSIL and should be taken into account in the follow‐up plan.
Initial experience and surgical outcomes of robotic‐assisted total hysterectomy using the da Vinci SP surgical system
Authors: Miyamura Hironori , Takada Kyohei , Ohwaki Akiko , Kobayashi Arata , Ito Mayuko , Nomura Hiroyuki , Nishio Eiji , Nishizawa Haruki 
Published: March 2024

AbstractIntroductionThe da Vinci SP surgical system is a surgical platform capable of implementing robotic‐assisted surgery through a single port and was first introduced in Japan at our hospital. In this paper, we describe our experience of the initial introduction of the da Vinci SP surgical system and its surgical outcomes. This is the first report on the surgical outcomes of using da Vinci SP, and its comparison with the conventional system in Japan.MethodsAfter developing an application for a highly difficult new medical technology in‐house, we compared the surgical outcomes (median values) of 15 patients who had undergone total hysterectomy at our hospital using the da Vinci SP (1‐port) system (SP group) for uterine myoma after March 2023 and of 154 patients who underwent total hysterectomy using the conventional da Vinci Xi (four ports) system (Xi group) for uteri weighing <500 g.ResultsThe results of the comparison of the characteristics between 15 patients in the SP group and 154 patients in the Xi group were as follows: uterus weight (g): 230 (90–500) versus 222 (55–496) (p = .35); surgical time (minutes): 199 (171–251) versus 198 (88–387) (p = .63); intraoperative blood loss (mL): 13 (5–82) versus 20 (2–384) (p = .17); and rate of surgical complication (%): 0.0 versus 1.3 (p = .66). The data indicated a comparable weight of the resected uterus, surgical time, intraoperative blood loss, and rate of surgical complications between the two groups.ConclusionRobotic‐assisted total hysterectomy using the da Vinci SP surgical system allowed clinicians to safely perform surgeries according to the conventional systems.
The role of endoplasmic reticulum stress in metabolic diseases and mammary epithelial cell homeostasis in dairy cows
Authors: Yonekura Shinichi 
Published: March 2024

AbstractHigh‐yielding dairy cows undergo various physiological stresses during the transitional phase of the calving cycle. In this period, they experience negative energy balance, subjecting the liver to significant metabolic stress from an influx of nonesterified fatty acids. This metabolic stress not only impairs liver function but also diminishes milk production. Early lactation dairy cows may develop endoplasmic reticulum (ER) stress in the liver, potentially leading to liver‐related diseases and contributing to ER stress in mammary epithelial cells, resulting in decreased milk production. Natural products that alleviate ER stress have been identified, and if further in vivo studies confirm their efficacy, they have potential as feed additives to prevent disease and reduce milk yield. Conversely, physiological levels of ER stress play a role in mammary gland development and positively influence protein synthesis in milk. Understanding the threshold level of ER stress in mammary tissue and its detailed mechanisms will be crucial in dairy farming.
Therapeutic applicability of cannabidiol and other phytocannabinoids in epilepsy, multiple sclerosis and Parkinson's disease and in comorbidity with psychiatric disorders
Authors: de Fátima dos Santos Sampaio Maria , de Paiva Yara Bezerra , Sampaio Tuane Bazanella , Pereira Messias Gonzaga , Coimbra Norberto Cysne 
Published: March 2024

AbstractStudies have demonstrated the neuroprotective effect of cannabidiol (CBD) and other Cannabis sativa L. derivatives on diseases of the central nervous system caused by their direct or indirect interaction with endocannabinoid system‐related receptors and other molecular targets, such as the 5‐HT1A receptor, which is a potential pharmacological target of CBD. Interestingly, CBD binding with the 5‐HT1A receptor may be suitable for the treatment of epilepsies, parkinsonian syndromes and amyotrophic lateral sclerosis, in which the 5‐HT1A serotonergic receptor plays a key role. The aim of this review was to provide an overview of cannabinoid effects on neurological disorders, such as epilepsy, multiple sclerosis and Parkinson's diseases, and discuss their possible mechanism of action, highlighting interactions with molecular targets and the potential neuroprotective effects of phytocannabinoids. CBD has been shown to have significant therapeutic effects on epilepsy and Parkinson's disease, while nabiximols contribute to a reduction in spasticity and are a frequent option for the treatment of multiple sclerosis. Although there are multiple theories on the therapeutic potential of cannabinoids for neurological disorders, substantially greater progress in the search for strong scientific evidence of their pharmacological effectiveness is needed.
DNA methylation profiling of myelodysplastic syndromes and clinical response to azacitidine: A multicentre retrospective study
Authors: Noguera‐Castells Aleix , Campillo‐Marcos Ignacio , Davalos Veronica , García‐Prieto Carlos A. , Valcárcel David , Molero Antonieta , Palomo Laura , Gattermann Norbert , Wulfert Michael , Chaparro‐González Lorea , Solé Francesc , Cabezón Marta , Jiménez‐Lorenzo María J. , Xicoy Blanca , Zamora Lurdes , De Stefano Alessia , Casalin Irene , Finelli Carlo , Follo Matilde Y. , Esteller Manel 
Published: March 2024

SummaryReal‐world data have revealed that a substantial portion of patients with myelodysplastic syndromes (MDS) does not respond to epigenetic therapy with hypomethylating agents (HMAs). The cellular and molecular reasons for this resistance to the demethylating agent and biomarkers that would be able to predict the treatment refractoriness are largely unknown. In this study, we shed light on this enigma by characterizing the epigenomic profiles of patients with MDS treated with azacitidine. Our approach provides a comprehensive view of the evolving DNA methylation architecture of the disease and holds great potential for advancing our understanding of MDS treatment responses to HMAs.
Orosomucoid 2 upregulation mediates liver injury‐induced colorectal cancer liver metastasis by promoting EMT and cell migration
Authors: Wei Xundong , Wang Lei , Yang Bing , Ma Yuanyuan , Yuan Wei , Ma Jie 
Published: March 2024

AbstractThe relationship between drug‐induced liver injury and liver metastasis of colorectal cancer and the underlying mechanisms are not well understood. In this study, we used carbon tetrachloride to construct a classic mouse liver injury model and injected CT26 colorectal cancer cells into the mouse spleen to simulate the natural route of colorectal cancer liver metastasis. Liver injury significantly increased the number of colorectal cancer liver metastases. Transcriptome sequencing and data‐independent acquisition protein quantification identified proteins that were significantly differentially expressed in injured livers, and orosomucoid (ORM) 2 was identified as a target protein for tumor liver metastasis. In vitro experiments showed that exogenous ORM2 protein increased the expression of EMT markers such as Twist, Zeb1, Vim, Snail1 and Snail2 and chemokine ligands to promote CT26 cell migration. In addition, liver‐specific overexpression of the ORM2 protein in the mouse model significantly promoted tumor cell liver metastasis without inducing liver injury. Our results indicate that drug‐induced liver injury can promote colorectal cancer liver metastasis and that ORM2 can promote cell migration by inducing EMT in tumor cells.
KLK10 derived from tumor endothelial cells accelerates colon cancer cell proliferation and hematogenous liver metastasis formation
Authors: Kato Kazuya , Noda Takehiro , Kobayashi Shogo , Sasaki Kazuki , Iwagami Yoshifumi , Yamada Daisaku , Tomimaru Yoshito , Takahashi Hidenori , Uemura Mamoru , Asaoka Tadafumi , Shimizu Junzo , Doki Yuichiro , Eguchi Hidetoshi 
Published: March 2024

AbstractTumor endothelial cells (TECs), which are thought to be structurally and functionally different from normal endothelial cells (NECs), are increasingly attracting attention as a therapeutic target in hypervascular malignancies. Although colorectal liver metastasis (CRLM) tumors are hypovascular, inhibitors of angiogenesis are a key drug in multidisciplinary therapy, and TECs might be involved in the development and progression of cancer. Here, we analyzed the function of TEC in the CRLM tumor microenvironment. We used a murine colon cancer cell line (CT26) and isolated TECs from CRLM tumors. TECs showed higher proliferation and migration than NECs. Coinjection of CT26 and TECs yielded rapid tumor formation in vivo. Immunofluorescence analysis showed that coinjection of CT26 and TECs increased vessel formation and Ki‐67+ cells. Transcriptome analysis identified kallikrein‐related peptide 10 (KLK10) as a candidate target. Coinjection of CT26 and TECs after KLK10 downregulation with siRNA suppressed tumor formation in vivo. TEC secretion of KLK10 decreased after KLK10 downregulation, and conditioned medium after KLK10 knockdown in TECs suppressed CT26 proliferative activity. Double immunofluorescence staining of KLK10 and CD31 in CRLM tissues revealed a significant correlation between poor prognosis and positive KLK10 expression in TECs and tumor cells. On multivariate analysis, KLK10 expression was an independent prognostic factor in disease‐free survival. In conclusion, KLK10 derived from TECs accelerates colon cancer cell proliferation and hematogenous liver metastasis formation. KLK10 in TECs might offer a promising therapeutic target in CRLM.