bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-term efficacy and safety of netakimab in patients with active ankylosing spondylitis: results of three years of use in the international multicentre, randomized, double-blind, phase III clinical trial BCD-085-5/ASTERA
Authors: Mazurov V. I. , Erdes Sh. F. , Gaydukova I. Z. , Dubinina T. V. , Pristrom A. M. , Kunder E. V. , Soroka N. F. , Kastanayan A. A. , Povarova T. V. , Zhugrova E. S. , Plaksina T. V. , Shesternya P. A. , Kropotina T. V. , Antipova O. V. , Smolyarchuk E. A. , Tsyupa O. A. , Abdulganieva D. I. , Lapshina S. A. , Krechikova D. G. , Gordeev I. G. , Nesmeyanova O. B. , Ilivanova E. P. , Strelkova A. V. , Tyrenko V. V. , Mikhailova E. A. , Eremeeva A. V. 
Published: February 2024

The article presents the results of the three-year use of netakimab (NTK) in patients with ankylosing spondylitis (AS) as part of the phase III BCD-085-5/ASTERA study.Objective: to evaluate the long-term efficacy and safety of NTK over a three-year period in patients with active AS.Material and methods. BCD-085-5/ASTERA – double-blind, multicenter, randomized phase III clinical trial that enrolled patients with active AS (BASDAI ≥4) and a back pain intensity ≥4 on a numeric rating scale with inefficacy or intolerance of non-steroidal anti-inflammatory drugs or biologic drugs. A total of 228 patients were randomized in a 1:1 ratio and assigned to either the NTK group or the placebo/NTK group. Starting at week 16, patients who did not achieve ASAS20 (20% improvement according to ASAS criteria) received NTK 120 mg once every 2 weeks in an open-label regimen. Patients who achieved ASAS20 response at week 52 in the NTK group and week 68 in the placebo/NTK group continued to receive NTK (120 mg every 2 weeks) until week 156 in the NTK group and until week 172 in the placebo/NTK group.Results and discussion. Over the course of three years of NTK use, most patients experienced a sustained decline in AS activity (according to ASDAS-CRP, BASDAI) with sustained response (ASAS20/40, ASAS5/6) to therapy. Most adverse events reported were mild to moderate. 36.7% of patients had adverse events, which were mainly laboratory abnormalities, blood and lymphatic system abnormalities and infectious complications.Conclusion. The clinical effect of NTK was maintained in most patients with AS over a three-year period, with no significant loss of response. NTK was well tolerated and the safety profile remained favorable.
Alflutop Russian longitudinal multicenter observational study: use in patients with chronic back pain (message 3)
Authors: Lila A. M. , Karateev A. E. , Alexeeva L. I. , Taskina E. A. , Danilov An. B. , Zhivolupov S. A. , Samartsev I. N. , Barantsevich E. R. , Rachin A. P. 
Published: February 2024

The use of slow-acting disease-modifying symptomatic drugs, such as bioactive concentrate from small marine fish (BCSMF, Alflutop), is considered a potential element of complex therapy for chronic non-specific back pain (CNBP).Objective: to evaluate the efficacy of the BCSMF in patients with CNBP in real-life clinical practice.Material and methods. An open observational study included 10,047 patients with CNBP (age – 58.3±14.9 years, 58.4% women) with moderate or severe pain – 60 [50; 70] mm on the visual analogue scale (VAS). All patients received a course of BCSMF medication: 1 ml intramuscular (IM) daily No. 20 or 2 ml IM every other day No. 10. 68.8 % of patients also took non-steroidal anti-inflammatory drugs. Treatment outcomes were assessed 10 days after completion of BCSMF therapy (30 days after initiation of treatment).Results and discussion. As a treatment result, the pain intensity according to the VAS decreased from 60 [50; 70] to 20 [10; 30] mm (p<0.0001), the patients’ overall health assessment according to the VAS increased from 50 [30; 60] to 80 [60; 90] mm (p><0.0001) and the quality of life assessment (EQ-5D) – from 0.52 [0.06; 0.66] to 0.8 [0.71; 1] points (p>< 0.0001). A good response to treatment (pain reduction >50%) was observed in 73% of patients. On average, an improvement was observed on the 8th [5; 10] day of BCSMF therapy. There were no serious adverse effects associated with the use of the drug. Older age, overweight, initially more severe pain, and the presence of comorbid conditions were slightly more frequently associated with a less pronounced response to therapy.Conclusion. The use of BCSMF rapidly and effectively reduces the severity of pain and other symptoms associated with CNBP.
The Effect of Green Human Resources Management Practices on Corporate Sustainability from the Perspective of Employees
Authors: Nart Sima , Bilgili Ahmet , Orgut Emine Demet 
Published: February 2024

Abstract
This study examines the impact of Green Human Resources Management (GHRM) in the textile and fashion industry on corporate sustainability (CS). In addition, the indirect effects of organizations’ environmental performance (EP) and employee commitment to CS are also examined. The research was carried out with the participation of the employees (n = 129) of Turkish organizations operating in the fashion and textile sector that adopt a sustainable business management approach. Structural equation modeling via smart PLS was used for data analysis. The findings showed that GHRM positively affects CS, and EP mediates this relationship. However, employee commitment did not have a mediating effect in this relationship. These results provide CS experts and managers with evidence-based insights into designing GHRM practices and sustainability strategies.
Risks in Identifying Gifted Students in Mathematics: Case Studies
Authors: Budínová Irena 
Published: February 2024

Abstract
The article discusses the risks involved in identifying gifted students in mathematics in the school environment. Although the theory of gifted students is widespread and available today, school practice shows many cases of gifted students who have not been identified in the school environment. The reasons for this are various. The article will present the theory related to this topic. The research was conducted as two case studies using qualitative research methods. Semi-structured interviews with parents and pupils were used, and the pupils were observed for a long time by the researcher. In the first case, it was a mathematically gifted pupil with dyslexia, and in the second case, it was a mathematically gifted pupil with an extremely high IQ. The result of the study was to find out in which moments the school did not provide support to the pupil in the two cases mentioned and what kind of help the pupil would appreciate at school. Both pupils were involved in a 1-year intervention in which the intention was to cultivate their mathematical thinking and expressions with the help of appropriately chosen tasks. The stated findings are important for practice and discussion about the training of future mathematics teachers, for which consistent professional training focusing, among other things, also on the education of gifted students is essential. Both case studies are part of long-term research dealing with the identification of gifted students.
Imaging in reconstructive microsurgery – current standards and latest trends
Authors: Blank Beate , Cai Aijia 
Published: February 2024

Abstract
In microsurgery, many different imaging techniques are available in both flap and lymphatic surgery that all come with their own advantages and disadvantages. In flap surgery, CT angiography is considered as the gold standard. Among others, Doppler ultrasound, color Doppler ultrasound, ICG, and smartphone-based thermal cameras are valuable imaging techniques. In lymphatic surgery, photoacoustic imaging, laser tomography, contrast-enhanced magnetic resonance imaging, and high frequency ultrasound stand available to surgeons next to the current standard of lymphoscintigraphy. It is crucial to know the advantages and disadvantages to various techniques and highly adviced to microsurgeons be capable of using a variety of them.
Thermally tunable binary-phase VO2 metasurfaces for switchable holography and digital encryption
Authors: Liao Yuan , Fan Yulong , Lei Dangyuan 
Published: February 2024

Abstract
Metasurface holography has aroused immense interest in producing holographic images with high quality, higher-order diffraction-free, and large viewing angles by using a planar artificial sheet consisting of subwavelength nanostructures. Despite remarkable progress, dynamically tunable metasurface holography in the visible band has rarely been reported due to limited available tuning methods. In this work, we propose and numerically demonstrate a thermally tunable vanadium dioxide (VO2) nanofin based binary-phase metasurface, which generates holographic information in the visible varying with temperature. The insulator-to-metal phase transition in VO2 nanofins allows two independent binary-phase holograms generated by machine learning to be encoded in the respective phases of VO2 and switched under thermal regulation. By elaborately designing the dimensions and compensated phase of VO2 nanofins, high-quality images are reconstructed at corresponding temperatures under appropriate chiral illumination. In contrast, much poorer images are produced under inappropriate chiral illumination. We further demonstrate the advantage of applying the VO2 phase-compensated metasurface in high-security digital encryption, where two desired character combinations are read out with appropriate excitations and temperatures, whereas one identical fraudulent message is received with inappropriate excitations. Our design approach offers a new and efficient method to realize tunable metasurfaces, which is promisingly adopted in dynamic display, information encryption, optical anti-counterfeiting, etc.
Single flake homo p–n diode of MoTe2 enabled by oxygen plasma doping
Authors: Zulfiqar Irsa , Gul Sania , Sohail Hafiz Aamir , Rabani Iqra , Gul Saima , Rehman Malik Abdul , Wabaidur Saikh Mohammad , Yasir Muhammad , Ullah Inam , Khan Muhammad Asghar , Rehman Shania , Khan Muhammad Farooq 
Published: February 2024

Abstract
Two-dimensional (2D) materials play a crucial role as fundamental electrical components in modern electronics and optoelectronics next-generation artificial intelligent devices. This study presents a methodology for creating a laterally uniform p–n junction by using a partial oxygen plasma-mediated strategy to introduce p-type doping in single channel MoTe2 device. The MoTe2 field effect transistors (FETs) show high electron mobility of about ∼23.54 cm2 V−1 s−1 and a current ON/OFF ratio of ∼106 while p-type FETs show hole mobility of about ∼9.25 cm2 V−1 s−1 and current ON/OFF ratio ∼105 along with artificially created lateral MoTe2 p–n junction, exhibited a rectification ratio of ∼102 and ideality factor of ∼1.7 which is proximity to ideal-like diode. Thus, our study showed a diversity in the development of low-power nanoelectronics of next-generation integrated circuits.
Zugang zu Forschungsdaten in den D-A-CH-Ländern: Eine Vermessung der (Un-)Zufriedenheit
Authors: Chaskel Rico , Getzner Michael , Fürnkranz-Prskawetz Alexia , Riphahn Regina T. , Schmidheiny Kurt 
Published: February 2024

Zusammenfassung
Umfassender Zugang zu relevanten Daten ist eine wesentliche Voraussetzung für exzellente Forschung und evidenzbasierte Wirtschaftspolitik. In diesem Beitrag sind die Ergebnisse gleichlautender Erhebungen der drei wirtschaftswissenschaftlichen Vereinigungen in Deutschland, Österreich und der Schweiz zur Zufriedenheit mit der Dateninfrastruktur unter Forschenden zusammengefasst. Die Zufriedenheit ist bestenfalls befriedigend, von einer exzellenten Ausstattung mit Daten sind die drei Länder noch weit entfernt. Die wesentlichen Probleme sehen die Befragten in der nicht ausreichenden Qualität und Aktualität, im ungenügenden Umfang und in der Unregelmäßigkeit der Daten. Zusätzlich fehlt häufig eine Verknüpfbarkeit bestehender Daten aus unterschiedlichen Quellen. Neben der dadurch beeinträchtigten Forschung hat eine ungenügende Dateninfrastruktur weitreichende Implikationen: Evidenzbasierte Politik- und Planungsentscheidungen im öffentlichen wie im privaten Sektor werden erschwert. Dies hat erhebliche Bedeutung für das Vertrauen in politische Entscheidungen und damit für die künftige politische Entwicklung insgesamt.
Current potential pathogenic mechanisms of copper-zinc superoxide dismutase 1 (SOD1) in amyotrophic lateral sclerosis
Authors: Wang Xin-Xin , Chen Wen-Zhi , Li Cheng , Xu Ren-Shi 
Published: February 2024

Abstract
Amyotrophic lateral sclerosis (ALS) is a rare neurodegenerative disease which damages upper and lower motor neurons (UMN and LMN) innervating the muscles of the trunk, extremities, head, neck and face in cerebrum, brain stem and spinal cord, which results in the progressive weakness, atrophy and fasciculation of muscle innervated by the related UMN and LMN, accompanying with the pathological signs leaded by the cortical spinal lateral tract lesion. The pathogenesis about ALS is not fully understood, and no specific drugs are available to cure and prevent the progression of this disease at present. In this review, we reviewed the structure and associated functions of copper-zinc superoxide dismutase 1 (SOD1), discuss why SOD1 is crucial to the pathogenesis of ALS, and outline the pathogenic mechanisms of SOD1 in ALS that have been identified at recent years, including glutamate-related excitotoxicity, mitochondrial dysfunction, endoplasmic reticulum stress, oxidative stress, axonal transport disruption, prion-like propagation, and the non-cytologic toxicity of glial cells. This review will help us to deeply understand the current progression in this field of SOD1 pathogenic mechanisms in ALS.
Evaluation of Test Methods and Environmental Conditions to Promote Efflorescence Formation Under Laboratory Conditions
Authors: Vickers T , Moukwa M 
Published: February 2024

Abstract
Several test procedures that induce formation of efflorescence on the surface of porous block specimens were investigated. This paper describes the tests that were investigated and the environmental conditions under which these tests were performed. A wicking procedure, run at an elevated temperature and low relative humidity, rapidly produces efflorescence on the surface of test samples. The rate of efflorescence formation was fastest at an elevated temperature and lower relative humidity and slowest at a cool temperature and high relative humidity. The wicking test can be used to rapidly determine the effect of changing mix proportion and the effectiveness of sealers and anti-efflorescence additives on the efflorescence potential of porous masonry units.
АКТУАЛЬНІ АСПЕКТИ ФОРМУВАННЯ ПРОФЕСІЙНОЇ ГОТОВНОСТІ МАЙБУТНІХ ФАРМАЦЕВТІВ
Authors: КУЗЕНКО ОЛЕКСАНДРА , ЛЕОЧКО НАТАЛІЯ 
Published: February 2024

У статті розкриваються актуальні аспекти формування професійної готовності майбутніх фармацевтів. Обґрунтовано, що впровадження сучасних підходів до організаційно-педагогічної діяльності в ЗВО суттєво активізує пізнавальну діяльність здобувачів, позитивно впливає на формування майбутніх фармацевтів з прогресивним способом мислення, здатних розв’язувати інноваційні завдання сучасної фармацевтичної галузі. Аргументується, що дієвим чинником формування фахової готовності здобувачів вищої фармацевтичної освіти стало впровадження компетентнісного і студентоцентрованого підходів до організації навчально-виховного процесу в ЗВО.
ПРИНЦИПИ ПІДГОТОВКИ МАЙБУТНІХ УЧИТЕЛІВ ПОЧАТКОВИХ КЛАСІВ ДО РЕАЛІЗАЦІЇ РІЗНОМАНІТНИХ РОЛЕЙ В ІНКЛЮЗИВНОМУ ОСВІТНЬОМУ ПРОСТОРІ
Authors: АКІМОВА Олена 
Published: February 2024

Професійна підготовка майбутніх фахівців спеціальності 013 Початкова освіта до реалізації різноманітних ролей в інклюзивному освітньому просторі здійснюється за паралельною моделлю. Зважуючи на необхідність упровадження цілісного підходу рівнів методології (філософський, загальнонауковий, конкретно-науковий та конкретно-фаховий), основними принципами підготовки майбутніх фахівців спеціальності 013 Початкова освіта до реалізації різноманітних ролей в інклюзивному освітньому просторі визначені: синергітизм, науковість, культуро-відповідність, едукаційность, гуманізація діяльності, об’єктивність, своєчасність, цілеспрямованість. Схарактеризовано ролі тьютора, ментора, коуча, фасилітатора майбутнього вчителя початкових класів, що відповідають основним засадам реалізації інклюзивної форми навчання в початковій школі.
Ramen – A Japanese National Dish with Chinese National Heritage
Authors: Kushner Barak 
Published: February 2024

The article is a reworking, by the author, of the first chapter of Slurp! A Social and Culinary History of Ramen – Japan’s Favorite Noodle Soup which was published in 2012 by Brill. It provides a history of traditional ramen as well as its offshoot, instant noodles.
Study on the Heterogeneity of the Stress Field in the Maduo Earthquake Fault Zone
Authors: Guan Zhaoxuan , Wan Yongge , Huang Shaohua , Feng Gan 
Published: February 2024

Abstract
The 2021 Maduo earthquake sequence occurred on the Jiangcuo fault zone in Qinghai, China. However, the earthquake sequence did not occur along a straight fault. Aftershocks in the southeast section deflected the aftershocks in the southeast section to the east, when the aftershocks in the northwest section bifurcated. To investigate the relationship between these eastward deflections, aftershock bifurcations, and fault activity, 150 focal mechanism solutions of the Maduo earthquake sequence are collected and processed, and then the stress fields in the subregion and whole region are subsequently determined by partitioning the sliding window from southeast to northwest. The results show that the overall tectonic stress field of the Maduo earthquake sequence exhibits northeast–southwest compression and northwest–southeast extension due to the northward compression of the Indian plate, causing rupture of the Kunlunshankou-Jiangcuo fault, which straightened the curved Maduo-Gander fault. The stress field at the deflection of the southeastern section of the source area differs significantly from the overall stress field. The plunge angle of the extensional stress axis in the southeastern deflection area is close to vertical, which is speculated to be due to the effect of the crack tip and the adjustment of local stress after the earthquake. The extensional stress axis at the bifurcated distribution of aftershocks in the northwestern section of the source area is slightly greater than of the overall stress field, indicating that the activation of the bifurcated hidden fault was triggered by the high rupture intensity and the adjustment of local stress. The reactivation of the hidden bifurcated fault results in local stress and causes decreasing seismicity west of the bifurcation area.
Limb lengthening and deformity correction in patients with severe fibular hemimelia: experience of the children's university hospital in Belgrade
Authors: Lazović M. , Leonchuk S. S. , Ducić S. , Imomov Sh. A. , Popkov D. A. 
Published: February 2024

Background Fibular hemimelia (FH) is a congenital disease manifested by valgus deformity and instability of the knee joint, shortening and deformity of the tibia, hypoplasia and deformities of the foot and ankle.The aim of this paper was to determine the efficacy of the strategy of separate reconstruction of the foot along with correction of tibia deformity, and then tibial lengthening in patients with FH of types 3 and 4 according to Paley.Methods This retrospective study is based on an analysis of the treatment of 12 children with severe FH. The patients, aged no older than 24 months, were treated for foot reconstruction along with correction of tibial deformity followed by a separate stage of tibial lengthening. Tibial lengthening was performed in the age 4.6 ± 1.2 years. The long-term result of treatment was evaluated at least 1 year after the end of tibial lengthening. Evaluation criteria after tibia lengthening were external osteosynthesis index, amount of lengthening, assessment of outcomes according to Lascombes. Walking ability was assessed using Gillette questionnaire.Results The approach we used gave excellent and good results in 83 % of cases after the first reconstructive stage. Complications and recurrences of deformities encountered during the first stage were eliminated during subsequent planned limb lengthening. The average magnitude of lengthening was 6.4 ± 2.4 cm (37.2 ± 12.4 % of the initial segment length). The index of external osteosynthesis was 22.9 ± 12.2 days/cm. Monofocal distraction osteosynthesis was used in 9 cases and bifocal osteosynthesis in three cases. The results of lengthening were classified by Lascombes as IA in 7 cases, IB in four cases, 2B in one case.Discussion In severe FH, the question of reconstruction or early amputation remains open. There are two opinions on the staging of reconstructive orthopedic surgery and tibial lengthening in young children with severe FH.Conclusion The strategy of reconstruction of the foot and ankle joint at an early age (16-24 months) in children with severe FH followed by lengthening of the lower leg (at the age of 4-6 years) proved to be effective and can be used when it is chosen by the patient's parents. In 3C type cases, the use of external fixation to correct the deformity and simultaneously lengthen the tibia at the first stage is an alternative reasonable strategy option.
Synthetic biomaterials based on hydroxyapatite and tricalcium phosphate: analysis of current clinical trials
Authors: Mukhametov U. F. , Ivliev D. S. , Gareev I. F. , Lyulin S. V. , Borzunov D. Yu. 
Published: February 2024

Introduction To date, a wide variety of synthetic materials, including metals, polymers and ceramics, have been proposed and used as a substitute for bone grafts in the field of traumatology/orthopedics, neurosurgery and oral and maxillofacial surgery (OMFS). However, the most studied materials are calcium phosphate ceramics (CPC), in particular hydroxyapatite and tricalcium phosphate, as well as their mixtures, called byphasic calcium phosphates. This interest stems from the fact that the main component of bone is the apatite mineral calcium phosphate. Hydroxyapatite and tricalcium phosphate are among the most commonly used and effective synthetic substitutes for bone grafts. They have not only osteoconductive properties, but also osteoinductive. These properties, combined with cell-mediated resorption, ensure complete regeneration of bone defects. This study will analyze existing clinical trials, registered on the clinicaltirals.gov website, on the use of hydroxyapatite and tricalcium phosphate in the field of traumatology and orthopedics, neurosurgery and OMFS.Aim To identify the potential for clinical use, as well as possible side effects, of CPC as a replacement for bone grafts.Materials and methods The search strategy was to use material from the clinicaltrials.gov website, which focused on key terms such as hydroxyapatite, tricalcium phosphate, hydroxyapatite and tricalcium phosphate, traumatology and orthopedics, maxillofacial surgery, dentistry, neurosurgery, bone, и diseases of the musculoskeletal system.Results and discussion As of November 2022, there were approximately 85 clinical trials with hydroxyapatite application, approximately 49 clinical trials with tricalcium phosphate, and approximately 16 clinical trials with the hydroxyapatite/tricalcium phosphate combination. Most of the studies were Phase 1-2, Phase 2, or Phase 4. Most focused on tibial trauma therapy, osteoporosis/osteopenia, alveolar bone resorption, and spinal surgery. It was found that full results were published only in 3, 7 and 2 clinical trials on the use of hydroxyapatite, tricalcium phosphate and their combination, respectfully. All clinical trials had similar preparation methods and all of those clinical trials produced positive results without serious side effects.Conclusion There is a wide potential for clinical use of CPC as synthetic bone graft substitutes without reports of serious side effects. Many preclinical and clinical studies are currently underway on the use of hydroxyapatite and tricalcium phosphate, and their future results will further explore their clinical potential.