bluuebunny/crossref_metadata_2025_split huggingface dataset:
The geography of eco-innovations and sustainability transitions: A systematic comparison
Authors: Hansmeier Hendrik , Kroll Henning 
Published: March 2024

Abstract
The need to address environmental challenges through innovation-based transformative change has become more urgent than ever and the spatial dimension of pathways towards sustainability has attracted increasing scholarly interest. Over the last decade, research on environmentally oriented innovation has entered the geographical discourse from different directions. This paper starts with the premise that, among other contributions, two main directions of research can be identified within the current geographical discourse that do not yet interface much – a broad, yet conceptually more traditional debate on eco-innovation and a newer discourse around socio-technical transitions that adds a further perspective. Having justified this assumption by a short literature review, we perform a keyword-based literature search, which confirms that there are indeed two distinct bodies of literature and few studies to date that integrate features from both fields. Following this, an in-depth review of the sources clarifies the differences in perspective and the common object of analysis of the basic systemic elements of actors, institutions and technologies. While this juxtaposition illustrates why the two fields of research have hardly cross-fertilised each other so far, it also shows that they are in substance far from irreconcilable. On the contrary, the nuanced synthesis of research findings reveals numerous complementarities that constitute promising avenues for future geographical research. These are considered necessary to improve the understanding of the geography of innovation-based transitions towards sustainability.
Impaired fertility in adenomyosis: a murine model reveals endometrial receptivity and progesterone resistance imbalances
Authors: Squatrito Marlyne , Vervier Julie , Bindels Jules , Bernet Laëtitia , Blacher Silvia , Nisolle Michelle , Munaut Carine 
Published: March 2024

In brief
The impact of adenomyosis on reproductive health needs to be fully understood. By using a murine model, this study provides novel insights into the nuanced mechanisms associated with fertility challenges and offers a foundation for targeted interventions.

Abstract
This study investigates the intricate relationship between adenomyosis and reproductive health using a murine model, offering novel insights into this prevalent gynecological disorder. Adenomyosis, characterized by the invasive growth of endometrial tissue into the myometrium, is believed to negatively impact fertility. However, the challenge lies in disentangling this influence, as adenomyosis often coexists with other gynecological diseases. A tamoxifen-induced mice model presents a significant advantage by enabling the specific study of adenomyosis, devoid of confounding influences of concurrent gynecological diseases such as endometriosis. Focusing exclusively on adenomyosis, our study aims to elucidate pathogenic mechanisms underlying fertility issues, focusing on estrous cyclicity, ovarian follicle development, and overall fertility. Our findings uncover disruptions in estrous cyclicity, characterized by an increased duration of time spent in the estrus phase in adenomyosis-induced mice. These disturbances are potentially linked to observed compromised folliculogenesis and the remarkable reduction in litter number and size in mice affected by adenomyosis. Moreover, this study unveils potential drivers of subfertility such as progesterone resistance and altered endometrial receptivity. Within the uteri of mice with adenomyosis, reduced expression of the progesterone receptor and a decreased expression of two implantation-related markers (HoxA10 and integrin β3) were observed. This comprehensive examination sheds light on the nuanced complexities of adenomyosis-associated reproductive challenges, providing a foundation for targeted interventions in addressing fertility issues related to this disease.
Riqueza y densidad de equinodermos en los arrecifes rocosos de Punta Amapala, El Salvador
Authors: Figueroa Segovia Laura Liseth , Segovia-Prado Johanna 
Published: March 2024

Introducción: Los equinodermos son animales estrictamente acuáticos y de los grupos de invertebrados marinos cuya importancia ecológica es crucial para los ambientes en donde habitan. La característica más destacada es su simetría pentarradial. Estos organismos pueden distribuirse en una amplia variedad de ambientes oceánicos, y no ser exclusivamente habitantes de las formaciones arrecifales. Se han registrado el total de 1 539 especies, de las cuales 717 pertenecen a Pacífico y 60 de ellas se han registrado en El Salvador.
Objetivo: El objetivo del trabajo fue registrar la riqueza y densidad de especies de equinodermos en arrecifes rocosos de Punta Amapala (La Unión).
Métodos: El muestreo fue llevado a cabo en cinco sitios, dos a 3 m de profundidad y tres a 6 m. Para esto, se utilizó snorkeling y buceo autónomo, recorriendo dos transectos de banda de 30 x 1 m. Dentro de los transectos, se realizó la identificación (riqueza) y contabilización (abundancia) de los organismos.
Resultados: La especie que presentó mayor densidad en los arrecifes de 3 m fue Echinometra vanbrunti (0.83 indv/m2), seguido por el ofiuroideo Ophiocomella alexandri (0.16 indv/m2) y Ophiocoma aethiops (0.16 indv/m2). Y en los arrecifes a 6 m fueron Ophiothela mirabilis (0.83 indv/m2), Ophionereis annulata (0.21 indv/m2), Ophiothrix rudis (0.08 indv/m2) y Ophiocomella alexandri (0.01 indv/m2).
Conclusiones: Estos organismos, cumplen con diversos roles ecológicos, como ser bioindicadores de calidad de agua al tolerar ciertos cambios en las condiciones físico-químicas, así como cumplir el papel de hospederos de macrofauna por las cavidades que forman algunos erizos. Es por ello que los esfuerzos de muestreo deben incrementarse en estas zonas para monitorear la calidad y salud de los arrecifes rocosos, cuyo papel es clave, por ser junto con Los Cóbanos, los de mayor extensión en el país.
Study of histopathology on Arbacia lixula (Arbaciidae: Arbacioida) and Paracentrotus lividus (Parachinidae: Camarodonta) with bald sea urchin disease symptoms in Gran Canaria Island, Spain
Authors: Núñez-González Raibel , Caballero María José , Padilla Daniel , Martín Barrasa José Luis , Castro Hernández José Juan 
Published: March 2024

Introduction: Sea urchin diseases have been documented in several locations worldwide, with reported occurrences of bacterial, protozoan, fungal, and algal infections.
Objective: This study aimed to investigate pathogen agents in populations of Arbacia lixula and Paracentrotus lividus along the coast of Gran Canaria Island (Central-East Atlantic, Spain).
Methods: Sampling was conducted at San Cristobal beach, on the Northeast side of the island, where sea urchins were manually collected from depths of 1-3 m during June, July, and October 2022. Swab samples were taken from the external and internal areas of the lesions and cultured on various media plates.
Results: Eight different pathogen agents, including bacteria and fungi, were identified, with Vibrio alginolyticus being the most frequently observed bacteria in all diseased sea urchin samples. Additionally, ciliated protozoans were found within the tests, potentially acting as opportunistic parasites.
Conclusions: This research provides a unique perspective on bald sea urchin disease by identifying a significant number of associated pathogens, including Candida, previously unreported in diseased organisms. Furthermore, the study highlights the presence of an inflammatory response in tissues with bacterial colonies, offering crucial insights into understanding this sea urchin disease.
Does the righting behaviour effectively reflect stress in Arbacia dufresnii Arbacioida: Arbaciidae)?
Authors: Chaar Florencia , Rubilar Tamara , Crespi-Abril Augusto C. 
Published: March 2024

Introduction: Righting behaviour has been used as a health indicator in response to stressor variables. Using this parameter in aquaculture could help to reduce mortality and improve welfare in the sea urchin Arbacia dufresnii culture.
Objective: The purpose of this study was to determine the effect of sex, diameter, and three stressor factors on the righting behaviour of the sea urchin A. dufresnii.
Methods: A total of 300 animals were evaluated for complete righting behaviour (CRB) time, with 100 of them also recording half righting behaviour (HRB) time. Three stressors were applied to the animals: serial repetitions (three successive turnings), temperature (24-hour shock), and spawning induction with KCl injection. A stopwatch was used to record the time, and a precision calliper was used to measure the diameter.
Results: Righting time was discovered to be diameter dependent but sex independent. The upper temperature limit of 19 °C had a significant effect on righting behaviour compared to 16 °C and 13 °C with CRB times up to 150 seconds. Serial repetitions and spawning had no significant effect. However, based on the recorded times, it can be deduced that spawning had an effect on the health of the animals, with CRB times of up to 150 seconds compared to the control, with lower times.
Conclusions: Complete righting behaviour appears to be an optimal indicator for evaluating the health and condition of the sea urchin A. dufresnii, but more tests would be performed to confirm the effect of the control treatment on post-spawning stress.
EGFR-T790M mutation associated with acquired resistance to first-generation EGFR tyrosine kinase inhibitors in Vietnamese Non-Small-Cell Lung Cancer patients
Authors: Hoan Le , Khanh Chi Tran , Van Khanh Tran , Thi Tra My Thieu , Nguyen Ngoc Cuong 
Published: March 2024

Background: non-small cell lung cancer (NSCLC) patients who had epidermal growth factor receptor (EGFR) mutations sensitive to EGFR tyrosine kinase inhibitors (TKIs) had a high response rate to target therapies. Epidermal growth factor receptor (EGFR) T790M mutation is the most common mechanism of acquired resistance to first-generation EGFR TKIs. Objective: The aim of this study was to analyze the incidence of EGFR T790 mutation, the progression-free survival (PFS) in the patients who progress on the first‑ generation EGFR‑TKIs. This study also investigates the correlation between T790M mutation and clinical, subclinical features, progression-free survival of NSCLC Vietnamese patients.
Patients and methods: We analyzed 66 NSCLC patients who had acquired resistance to first-generation EGFR-TKIs. The clinical data, PFS and the mechanism of acquired resistance were obtained. The Kaplan-Meier method and the log-rank test were used to analyze the PFS and compare between subgroups of patient characteristics. The correlations between the patient’s characteristics and EGFR-T790M mutation status were analyzed by Chi-square and Fisher’s exact tests.
Results: At the progressive period, EGFR T790M mutation was detected in 54.5% of patients. The median PFS were 14.48 ± 3.9 months (range: 8- 26 months). Patients who were older than 60 years old or had comorbidities had significantly shorter PFS than the subgroups without (P≤0.05). The age, gender, smoking status, comorbidities, pathological features were not significantly correlated with the development of EGFR-T790M (P > 0.05). The average PFS was not significantly different between the EGFR-T790M group and the non-EGFR-T790M group (P=0.642).
Conclusion: In our cohort study, more than half of all patients had T790M mutation after being treated with first-generation EGFR TKIs. Age and comorbidities were associated with PFS but the EGFR-T790M mutation was not correlated with PFS.
PENGARUH PERSEPSI PRODUK UNGGULAN DAN KUALITAS PELAYANAN TERHADAP LOYALITAS PASIEN POLIKLINIK BEDAH DI RSI PKU MUHAMMADIYAH PEKAJANGAN
Authors: Susanto Susanto , Iffah Rikhlatul 
Published: March 2024

The Islamic Hospital PKU Muhammadiyah Pekajangan is a type C private hospital that is growing in Pekalongan. The successful hospital in the future are hospitals that have a competitive power. To win the competition the hospital must provide value and satisfaction to customers or patients through quality of products or services with competitive costs. The Islamic Hospital PKU Muhammadiyah Pekajangan already has a competitive product that is surgical oncology, surgical urology, neurosurgery. In addition The Islamic Hospital PKU Muhammadiyah Pekajangan should be able to know the quality of services provided and understand the interests and patients behavior to use the hospital services if needed health services at the next time.
To know the influence of competitive product perception to patient loyalty in The Surgical Clinic of Islamic Hospital PKU Muhammadiyah Pekajangan, and determine the influence of services quality perceptions to patient loyalty in The Surgical Clinic of Islamic Hospital PKU Muhammadiyah Pekajangan, as well as investigate the influence of competitive product and services quality perception together against patient loyalty in The Surgical Clinic of Islamic Hospital PKU Muhammadiyah Pekajangan.
The study was quantitative research with cross sectional design. The study was conducted on May-June 2011 in The Surgical Clinic of Islamic Hospital PKU Muhammadiyah Pekajangan. The population was all patients who had used services in The Surgical Clinic of Islamic Hospital PKU Muhammadiyah Pekajangan. The number of samples was 100 respondents. The sampling design was purposive sampling. Data was analyzed used descriptive and inferential statistics with multiple linear regression.
The research result showed that competitive products perception influenced patient loyalty (Sig. 0.005 <0.05), and services quality perception influenced patient loyalty (Sig. 0.000 <0.05), as well as competitive products and services quality jointly influenced patient loyalty in The Surgical Clinic of Islamic Hospital PKU Muhammadiyah Pekajangan (Sig. 0.000 <0.05).
The perception of competitive products and services quality perception which consists of communication, tangibles, empathy of nursing staff, assurance, responsiveness of the administrative staff, security, responsiveness physician either partially or jointly influence patient loyalty in The Surgical Clinic of Islamic Hospital PKU Muhammadiyah Pekajangan.
PENGARUH PEMBERIAN REWARDS DAN LINGKUNGAN KERJA TERHADAP PRESTASI KERJA KARYAWAN DI RSI MUHAMMADIYAH KENDAL
Authors: Riyanti Lena , Susanto Susanto , 'Aini Qurratul 
Published: March 2024

Work performance is the result of the quality and quantity achieved by an employee in their duties performing. Accomplishments can be achieved by increasing the satisfaction that can be realized giving Rewards proportionally and fair and to create a conducive working environment. Harmonious relationship that exists between a leader-employee is also needed among employees with one another to create a conducive working environment. The results of preliminary studies on Muhammadiyah Islamic Hospital of Kendal seen a lot of indiscipline and delay the return of earlier of employees and the number continues to increase. This research was quantitative descriptive with cross sectional research planning. Research populations were employees / workers of Muhammadiyah Islamic Hospital of Kendal. The sampling technique in this research is using proportions stratified random sampling with the number of sample as much as 137 people. Retrieval of data using questionnaires. Analysis of data using multiple linear regression analysis. There is an effect of giving rewards to employees' achievement of Muhammadiyah Islamic Hospital of Kendal (p<0,05). There is an influence of work environment of employees' achievement on Muhammadiyah Islamic Hospital of Kendal (p<0,05). There is an effect of giving rewards and working environment of employees' achievement on Muhammadiyah Islamic Hospital of Kendal.
ANALISIS DESKRIPTIF GAYA KEPEMIMPINAN SITUASIONAL KEPALA RUANGAN PERAWATAN RUMAH SAKIT PKU MUHAMMADIYAH YOGYAKARTA
Authors: Syah Deby Zulkarnain Rahadian , Tjahjono Heru Kurnianto 
Published: March 2024

The PKU Muhammadiyah HospitalOf Yogyakarta is referred Islamic hospital type B in Special Governmental State Yogyakarta and Central Java. In spite of being referred hospital, in giving service and nursing care has not been optimal. Head of nursing section has significant role in organizing associate nurse in effort of better service. A successful head section must be a good identifier and could appreciating the spirit of curiosity. Four situational leadership style such as, instructing, consulting, participating and delegating, will be analyze to see the tendency of leadership style that be used by the head of nursing section of PKU Muhammadiyah Hospital of Yogyakarta.This research is the quantitative-descriptive research. Measurement tools of this research using questioners that being distribute to 94 respondent. The subject of this research is vocational nurse on inpatient room of the PKU Muhammdiyah Hospital of Yogyakarta.Result of this research in the way of leadership assessed by associate nurse on head nursing section in patient room shows that ibnu shina room used consulting style 72,7%, marwah 56,3% consulting, roudhoh 63,3% consulting, arafah 53,8% participating, shofa-musdalifah 71,4% consulting, zam-zam 81,8% participating, and multazam 72,2% consulting.The style of situational leadership dominantly applied by the head nurse section of PKU based on the assessment of associate nurse is consulting leadership. The style of situational leadership not applied by the head nurse section is instructing.
ANALISIS PERHITUNGAN UNIT COST PADA TINDAKAN TONSILEKTOMI DENGAN METODE ACTIVITY BASED COSTING (STUDI KASUS DI RUMAH SAKIT PKU MUHAMMADIYAH YOGYAKARTA)
Authors: Vinensa Elga Ria , Nazarudin Ietje , Maryati Triyani 
Published: March 2024

Background: Private hospitals should strive to have the technical capability to manage and calculate costs based on the condition that both hospitals and facilities that can use the Indonesian Case Based Group (INA CBG) appropriately. RS PKU Muhammadiyah Yogyakarta as one of the private hospitals that participate and support the government's program of the Sistem Jaminan Sosial Nasional.Calculating the unit cost of a tonsillectomy was done as a study of the correspondence between the cost of services and a health claim
Methods:The study was a descriptive qualitative case study design. Tonsillectomy unit cost calculation using activity based costing (ABC) with the goal difference obtained unit costs plus a margin to claim CBG INA in 2012.
Result: Based on the calculation, the unit cost of services tonsillectomy with activity-based costing method is Rp. 2.265.732. ABC unit cost calculations result in a greater cost than the claims of INA CBG so get the difference in cost of Rp. 785.034.
Conclusions: There is a negative difference between the calculation of service bi tonsillectomy ABC method with INA CBG claim. So that needs to be done by the hospital cost efficiency.
PENGARUH STRESSOR PEKERJAAN TERHADAP MUTU PELAYANANPERAWAT DI BANGSAL RAWAT INAP RSUD SUKOHARJO
Authors: Andi Muhammad Alwi , Rosa Elsye Maria 
Published: March 2024

Stressor of nurse work is an inability of nurse to face any condition or situation in work environment. Stressor of work consist of workload, physical environment, individual, group, and organization which is the source of stressor. The research identified the effect of work stressor on the quality of nurse care in inpatient wards of Sukoharjo Regional Public Hospital. The type of research is quantitative research with Cross-Sectional approach. The populations are all nurses who served in inpatient wards of Sukoharjo Regional Public Hospital. The samples are 81 nurses by using total sampling. There was no workload effect on the quality of nurse care (p 0,365; B -0,104). There was physical environment effect on the quality of nurse care (p 0,004; B 0,818). There was indiviual effect on the quality of nurse care (p 0,001; B 1,875). There was no group effect on the quality of nurse care (p 0,555; B 0,244). There was no organization effect on the quality of nurse care (p 0,640; B 0,184). The negative effect of stress in high level influenced the care to patient. The higher the perceived work stress would influence the quality of nurse care in inpatient wards of Sukoharjo Regional Public Hospital.
PENGISIAN SIGN IN DALAM MENINGKATKAN KEPATUHAN SAFE SURGERY DI RUMAH SAKIT PKU MUHAMMADIYAH YOGYAKARTA II
Authors: Saputra Andri Firman , Rosa Elsye Maria 
Published: March 2024

Background: Complications and deaths due to surgery become one of the global health problems. World Health Organization estimates that at least half a million deaths due to preventable surgical. An effort to improve the quality of surgical services including the Surgical Safety Checklist to use made by World Health Organization. Compliance to use this surgery checklist which is can increase the number of safe surgery,reduce the wrong site surgery and nearmiss.
Method: This research is a qualitative action research design. The study population was all the doctors and nurse anesthetist. Number of samples 6 people. The data is collected by observation sheet Surgical Safety Checklist: Sign In RS PKU Muhammadiyah Yogyakarta Unit II for 3 cycles of observation.
Result and Discussion: The results of observations on the first to the third cycle shows that all disobeying nurse anesthetist (100%) the Surgical Safety Checklist to fill: Sign In. The results of the response every cycle and a structured interview with the anesthesiologist showed that nurses are still confused how to use the checklist, the checklist has not been a necessity, the culture of patient safety is still minimal, lack quality of human resources, lack of supervision and lack of socialization mechanisms Surgical Safety Checklist noncompliance that influence nurses Sign In to to fill.
Conclusion: Completing Sign In in the installation of surgery center in PKU Muhammadiyah Yogyakarta Unit II Hospital is noncompliance, because they still haven’t got the identity bracelet mounted on a patient who will be operating and marking the location of a rare surgery. Advice to hospital are to create a Standard Operating Procedure (SOP), SOP socialize regularly, make in-house training, increase the commitment of doctors and nurses, create a surveillance system, create a system of reward and punishment.
Pencarian Tugas Akhir dengan Ontologi dan Boyer-Moore (Studi Kasus: Jurusan Teknik Informatika UNSRI)
Authors: Rodiah Desty , Yunita Yunita , Yusliani Novi 
Published: March 2024

Website sipeta.ilkom.unsri.ac.id adalah website yang menampung data tugas akhir mahasiswa Jurusan Teknik Informatika UNSRI. Namun website tersebut menggunakan penyimpanan dengan basis data biasa. Pada penelitian ini membuat pencarian data tugas akhir mahasiswa dengan memanfaatkan web semantik ontologi agar data yang dimiliki tidak hanya memiliki nilai, tetapi juga memiliki pengetahuan tentang relasi antar informasi yang saling berkaitan. Komponen yang digunakan dalam teknologi semantik adalah RDF yang dipergunakan sebagai representasi pengetahuan yang digunakan, kemudian SPARQL yang digunakan sebagai query untuk mengambil informasi yang terdapat dalam Ontologi RDF. Selain itu juga digunakan Algoritma Boyer Moore untuk mendapatkan nilai similarity antara data yang didapatkan dari hasil pencarian dengan keyword yang dimasukkan. Jenis pencarian yang dirancang ada 3 pencarian yaitu keyword search, simple search dan advanced search. Dan ketiga pencarian tersebut juga akan di kombinasikan dengan algoritma Boyer Moore. Hasil pencarian dengan ontologi dengan pencarian dengan ontologi dan Algoritma Boyer Moore dihasilkan bahwa pencarian dengan Boyer Moore membutuhkan waktu lebih lama secara rata-rata sekitar >=0,0001 perdetik dalam 5 kali percobaan dibandingkan pencarian dengan ontologi saja. Untuk Algoritma Boyer Moore dilakukan pengujian dengan ROC didapatkan hasil akurasi sebesar 99,84% untuk 16 kali percobaan.