bluuebunny/crossref_metadata_2025_split huggingface dataset:
Plasma microRNA expression in adolescents and young adults with endometriosis: the importance of hormone use
Authors: Brady Paula , Yousif Abdelrahman , Sasamoto Naoko , Vitonis Allison F. , Fendler Wojciech , Stawiski Konrad , Hornstein Mark D. , Terry Kathryn L. , Elias Kevin M. , Missmer Stacey A. , Shafrir Amy L. 
Published: April 2024

IntroductionPrior studies have investigated the diagnostic potential of microRNA (miRNA) expression profiles for endometriosis. However, the vast majority of previous studies have only included adult women. Therefore, we sought to investigate differential expression of miRNAs among adolescents and young adults with endometriosis.MethodsThe Women's Health Study: from Adolescence to Adulthood (A2A) is an ongoing WERF EPHect compliant longitudinal cohort. Our analysis included 64 patients with surgically-confirmed endometriosis (96% rASRM stage I/II) and 118 females never diagnosed with endometriosis frequency matched on age (median = 21 years) and hormone use at blood draw. MicroRNA measurement was separated into discovery (10 cases and 10 controls) and internal replication (54 cases and 108 controls) phases. The levels of 754 plasma miRNAs were assayed in the discovery phase using PCR with rigorous internal control measures, with the relative expression of miRNA among cases vs. controls calculated using the 2−ΔΔCt method. miRNAs that were significant in univariate analyses stratified by hormone use were included in the internal replication phase. The internal replication phase was split 2:1 into a training and testing set and utilized FirePlex miRNA assay to assess 63 miRNAs in neural network analyses. The testing set of the validation phase was utilized to calculate the area under the curve (AUC) of the best fit models from the training set including hormone use as a covariate.ResultsIn the discovery phase, 49 miRNAs were differentially expressed between endometriosis cases and controls. The associations of the 49 miRNAs differed by hormone use at the time of blood draw. Neural network analysis in the testing set of the internal replication phase determined a final model comprising 5 miRNAs (miR-542-3p, let-7b-3p, miR-548i, miR-769-5p, miR-30c-1-3p), yielding AUC = 0.77 (95% CI: 0.67–0.87, p &lt; 0.001). Sensitivity in the testing dataset improved (83.3% vs. 72.2%) while the specificity decreased (58.3% vs. 72.2%) compared to the training set.ConclusionThe results suggest that miR-542-3p, let-7b-3p, miR-548i, miR-769-5p, miR-30c-1-3p may be dysregulated among adolescent and young adults with endometriosis. Hormone use was a significant modifier of miRNA dysregulation and should be considered rigorously in miRNA diagnostic studies.
Effectiveness of applying auricular acupressure to treat insomnia: a systematic review and meta-analysis
Authors: Jun Li , Xiong Li , Wen Yu , Yongxiang Wang 
Published: April 2024

BackgroundInsomnia affects the quality of life of a significant number of individuals worldwide. Despite the fact that pharmaceutical sleep treatments have shown brief enhancements in sleep quality, these are still not recommended for the long-term management of sleep issues. To deal with this problem, our study aims to assess the effectiveness of auricular acupressure for treating insomnia by conducting a systematic review and meta-analysis.MethodData from randomized controlled trials (RCTs) of auricular acupressure for insomnia was collected from five English-language databases (Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, AMED, and CINAHL) and four Chinese databases (CBM, CNKI, CQVIP, and Wanfang). Relevant data were extracted by two reviewers. I2 statistics were adopted to appraise heterogeneity. A network meta-analysis was applied to compare the effect of auricular acupressure with other methods.ResultIn all, 23 RCTs involving a total of 1,689 patients were included. The results demonstrated a significant decrease in the Pittsburgh Sleep Quality Index (PSQI) score for the intervention group compared to the control group [SMD = −1.30, 95% CI (−1.65, −0.96), I2 = 90%]. Furthermore, the group receiving auricular acupressure in addition to usual care showed a lower PSQI score compared to the usual care group [SMD = −1.13, 95% CI (−1.33, −0.93), I2 = 23%]. Auricular acupressure was found to enhance the effectiveness of estazolam in improving PSQI score, with the combination of auricular acupressure and estazolam resulting in a lower PSQI score [MD = −4.8, 95% CI (−7.4, −2.1)]. Importantly, no serious adverse events were reported. In patients with insomnia following stroke, the intervention group (which received auricular acupressure) exhibited a lower PSQI score compared to the control group [SMD = −0.74, 95% CI (−1.03, −0.46), I2 = 0%]. Similarly, in patients with insomnia related to cancer, the intervention group (receiving auricular acupressure) demonstrated a lower PSQI score compared to the control group [SMD = −0.99, 95% CI (−1.37, −0.61), I2 = 0%].ConclusionThe effects of auricular acupressure on insomnia are comparable to those of estazolam. Furthermore, auricular acupressure can serve as a complementary treatment to estazolam or other interventions, effectively improving symptoms of insomnia.
Discriminatory, yet socially accepted? Targets’ perceptions of subtle and blatant expressions of ethno-racial prejudice
Authors: Stanke Franziska A. , Kuper Niclas , Fetz Karolina , Echterhoff Gerald 
Published: April 2024

IntroductionExtant research has studied prejudice expressions mainly from the majority perspective. We examined whether prejudice expressions conceptualized as subtle (vs. blatant) are perceived differently by their targets.MethodsParticipants who self-identified as potential targets of ethno-racial or religious prejudice (e.g., anti-Muslim, anti-Asian, anti-Arab, anti-Slavic, and anti-Black prejudice), answered questions about verbal expressions of prejudice taken from the subtle and blatant prejudice scales in an online survey.ResultsItems of the subtle (vs. blatant) prejudice scale were rated as more socially accepted and less discriminatory, elicited less negative emotions, and were reported to be experienced more often. Subtle expressions of prejudice were not more familiar to participants than blatant ones. Remarkably, blatant prejudice expressions were also perceived as relatively socially accepted and subtle prejudices as relatively discriminatory, as indicated by mean ratings above the scale midpoint. Lower discrimination ratings of subtle (vs. blatant) prejudice expressions were mainly due to perceptions of expressions exaggerating cultural differences. Exploratory analyses indicate that participants who reported more (vs. less) frequent overall exposure to the prejudice expressions perceived subtle and blatant stimuli as similarly discriminatory. This finding is compatible with the idea that individuals factor their personal experiences with prejudice into their assessments of discrimination.DiscussionWe discuss implications for interventions, especially regarding the social acceptability of blatant prejudice and promoting awareness of the discriminatory impact of subtle prejudice.
Exploring sleep heart rate variability: linear, nonlinear, and circadian rhythm perspectives
Authors: Hasegawa Mizuki , Sasaki Mayuko , Umemoto Yui , Hayashi Rio , Hatanaka Akari , Hosoki Marino , Farag Ahmed , Matsuura Katsuhiro , Yoshida Tomohiko , Shimada Kazumi , Hamabe Lina , Takahashi Ken , Tanaka Ryou 
Published: April 2024

BackgroundHeart rate variability (HRV) is believed to possess the potential for disease detection. However, early identification of heart disease remains challenging, as HRV analysis in dogs primarily reflects the advanced stages of the disease.Hypothesis/objectiveThe aim of this study is to compare 24-h HRV with sleep HRV to assess the potential utility of sleep HRV analysis.AnimalsThirty healthy dogs with no echocardiographic abnormalities were included in the study, comprising 23 females and 7 males ranging in age from 2 months to 8 years (mean [standard deviation], 1.4 [1.6]).MethodsThis study employed a cross-sectional study. 24-h HRV and sleep HRV were measured from 48-h Holter recordings. Both linear analysis, a traditional method of heart rate variability analysis, and nonlinear analysis, a novel approach, were conducted. Additionally, circadian rhythm parameters were assessed.ResultsIn frequency analysis of linear analysis, the parasympathetic index nHF was significantly higher during sleep compared to the mean 24-h period (mean sleep HRV [standard deviation] vs. mean 24 h [standard deviation], 95% confidence interval, p value, r-family: 0.24 [0.057] vs. 0.23 [0.045], 0.006–0.031, p = 0.005, r = 0.49). Regarding time domain analysis, the parasympathetic indices SDNN and RMSSD were also significantly higher during sleep (SDNN: 179.7 [66.9] vs. 156.6 [53.2], 14.5–31.7, p &lt; 0.001, r = 0.71 RMSSD: 187.0 [74.0] vs. 165.4 [62.2], 13.2–30.0, p &lt; 0.001, r = 0.70). In a geometric method of nonlinear analysis, the parasympathetic indices SD1 and SD2 showed significantly higher values during sleep (SD1: 132.4 [52.4] vs. 117.1 [44.0], 9.3–21.1, p &lt; 0.001, r = 0.70 SD2: 215.0 [80.5] vs. 185.9 [62.0], 17.6–40.6, p &lt; 0.001, r = 0.69). Furthermore, the circadian rhythm items of the parasympathetic indices SDNN, RMSSD, SD1, and SD2 exhibited positive peaks during sleep.ConclusionThe findings suggest that focusing on HRV during sleep can provide a more accurate representation of parasympathetic activity, as it captures the peak circadian rhythm items.
Friedricha von Hayeka poglądy na temat moralności
Authors: Šimo Halina 
Published: April 2024

Celem artykułu jest przedstawienie i analiza poglądów F.A. von Hayeka na temat moralności (zebranych z różnych jego dzieł) oraz wskazanie na ich znaczenie dla współczesnych dyskusji w filozofii politycznej, jak również w etyce. Warto podjąć ten temat z uwagi na potrzebę opracowania myśli aksjologicznej Hayeka, wybitnego myśliciela o poglądach mocno skrystalizowanych, spójnych i oryginalnych. Jego refleksje mają potencjał, aby wiele wnieść w debaty na temat wartości, są one jednak mało znane lub niesłusznie pomijane. W pierwszej części rozważań wyjaśniam, w jaki sposób według Hayeka moralność wspiera wolność indywidualną, a więc wartość centralną w jego aksjologii: społeczeństwo jest wyposażone w moralność (obok prawa stanowionego) w celu zachowania porządku przy minimum stosowania przymusu (istota ładu wolnościowego). Rozdział drugi poświęcam omówieniu wyróżnionych przez Hayeka rodzajów moralności, wskazuję, w jaki sposób, wzajemnie się uzupełniając, konstytuują one tradycję moralną. Chodzi o zespoły zasad fundujących z jednej strony ład naturalny (jego normy odpowiadają instynktownym postawom słusznie dochodzącym do głosu w małych wspólnotach), z drugiej strony – tzw. ład rozszerzony (związane z nim normy nie są zgodne z instynktami, regulują współistnienie obcych sobie ludzi wchodzących w anonimowe relacje w obrębie dużych społeczności ludzkich). W rozdziale trzecim przedstawiam Hayeka poglądy w kwestii możliwości uzasadnienia norm tradycyjnej moralności. Chodzi zwłaszcza o rozwinięcie poglądu, że uznawanie zasad moralności jest kluczowe dla społeczeństwa wolnościowego, i to niezależnie od tego, czy mamy dla nich zadowalające racjonalne uzasadnienie. W końcowej części rozważań zasygnalizowane jest znaczenie Hayeka koncepcji moralności w zakresie nurtów myśli politycznej, z którymi Hayek jest wiązany (indywidualizm, liberalizm, konserwatyzm), jak również dla metaetyki (próba odtworzenia zasad konstytutywnych dla cywilizacji; głos w dyskusji między perspektywą bezstronną i stronniczą w etyce).
The Beauty of New Urban Functions
Authors: Kleszcz Justyna 
Published: April 2024

The paper aims to answer the question of how the aesthetic value of functions that appear as a novelty in contemporary urban space is given on the example of buildings intended for urban agriculture. Due to the fact that most of them are created as part of multi-functional facilities and constitute an extension of the existing infrastructure, the way they are shaped and the final aesthetic expression is the result of technical needs and capabilities. Natural beauty in the city has been, often by contrast, associated with the emergence of greenery, which is built spontaneously, creating principles that inspire the discovery of a perfect geometry, a harmony within each urban scale. Hence the potential for a new function, which, although its subject is nature, is nevertheless enclosed by architectural form by design. The last decade has brought the first realizations of agriculture integrated into the urban fabric and treated as an urban function, so it has not yet managed to develop its own clearly defined aesthetic. However, the influence of several basic functions from which urban agriculture originates is clearly visible in this respect, i.e. intensive agriculture, industry, housing and recreation. These aesthetics are often in contradiction, but they already give the opportunity to pick out certain directions that are supposed to ensure a harmonious combination of seemingly contradictory elements. The use of the symbolism of a place, the existing characteristic elements that bear witness to local traditions, which are transformed for the new function, and their inscription, either by contrast or continuation in the existing urban context are often used tools. This analysis is based on examples of completed complexes and buildings for which it is possible to objectively assess the premises causing a sense of harmony or disharmony on various levels of reading space – physical, symbolic or historical. The discussed examples include housing developments, industrial and logistics functions, office and exhibition space.
Free vibrations of variablesection beams taking rotational and frictional forces into account
Authors: Baragunova L. A. , Shogenova M. M. , Shogenov O. M. , Yafaunov E. A. 
Published: April 2024

Introduction. Beams are widely used in the construction industry as load-bearing structures of bridges, overpasses, coverings, slabs, stairs, equipment platforms, etc. In order to fully utilize the bearing capacity of such structures and to reduce the rate of material consumption, beams of variable cross-section along the length can be used. During operation, such structural elements are subjected to various types of vibrations, which determines the relevance of studying various aspects of vibrational motion.Aim. To apply numerical methods for studying the influence of rotational inertial forces in the presence of viscous frictional forces on free vibrations of variable-section beams. This area of research presents interest, since the calculations are directly related to the determination of frequencies and forms of natural vibrations of structures.Materials and methods. Free vibrations were described by a homogeneous partial differential equation of hyperbolic type. The methods of variable separation and finite differences were used. A discrete domain in the form of a set of uniform grid nodes and a homogeneous system of algebraic equations were introduced. The system of equations in the matrix-vector form was used.Results. The spectra of natural frequencies, damping coefficients, and eigenforms of beam vibrations are determined. It is shown that the coefficient matrix has a banded and pentadiagonal form. The matrix elements are functions of the characteristic index. The damping coefficient and the frequency of free vibrations are determined from a system of two nonlinear equations. The solution of the system of equations is found using the method of coordinate descent. An example of calculation of a welded I-beam is considered. Five elements of the spectra of damping coefficients and natural frequencies are calculated.Conclusions. State-of-the-art MATLAB solvers allows numerical and graphical methods to be combined. In the solved examples, the advantages of these methods were successfully applied to determine the eigenvalues of matrices and eigenfunctions. The high validity and accuracy of the results obtained confirm the simplicity and versatility of the methodology for determining the characteristics of free vibrations of beams of variable cross-section.
La Eficacia de la Defensa Jurídica de los Predios Estatales por las Entidades Públicas en Perú
Authors: Atoche Pacherres Patricia , García Taboada Augusto Fortuna 
Published: April 2024

La Superintendencia de Bienes Estatales (SBN) es un organismo público descentralizado adscrito al Ministerio de Vivienda, Construcción y Saneamiento cuya finalidad es normar y supervisar los actos de adquisición, administración, disposición y registro de los bienes estatales que realicen las entidades, a efectos de lograr una administración ordenada y eficiente. El presente artículo tiene como propósito analizar y difundir las normas referidas a la defensa y recuperación de la propiedad estatal establecida en la Ley N° 29151, Ley General del Sistema Nacional de Bienes Estatales y su Reglamento y a la Ley N° 30230, Ley que establece medidas tributarias, simplificación de procedimientos y permisos para la promoción y dinamización de la inversión en el país. Con la dación de la Ley N° 30230, se modifica el artículo 920 del Código Civil vigente y unas reglas para la defensa posesoria extrajudicial de bienes inmuebles de propiedad privada.
El Cambio Climático y los Sistemas de Tratamiento de Aguas Residuales
Authors: Avila Manuel Alberto , Argueta Dennis 
Published: April 2024

El retraso de infraestructura, la contaminación de los cuerpos de agua, reducción del número de fuentes disponibles, el costo de agua apta para consumo humano y el cambio climático son de los problemas ambientales más graves al que se enfrenta la humanidad en la actualidad, la atmósfera no tiene fronteras, no puede detenerse “a voluntad”. Cepal, 2012 estima que menos del 10% de aguas residuales son tratadas antes de ser devueltas al cuerpo receptor, más del 90% de cuerpos de agua están siendo contaminados en la región centroamericana. La temperatura es uno de los parámetros físicos más importantes en el agua, influye en el retardo o aceleración de la actividad biológica. Es importante desarrollar y construir tecnologías, que contribuyan con la reducción de GEI y saneamiento, contribuyendo a la mitigación del cambio climático, como por ejemplo con una planta macrófita(E. Crassipes) que puede ser utilizada para absorber nitrógeno y fósforo a diferentes temperaturas medias máximas dentro de un tanque con aguas residuales. Los resultados obtenidos con E. Crassipes indican la capacidad significativa para absorber nitrógeno y fósforo en diferentes temperaturas. A medida que la temperatura varía, esta capacidad puede ser afectada, pero su capacidad fitodepuradora sigue siendo significativa. Es por ello que se determinó que el aporte de una planta macrófica como lo es la E. Crassipes en los sistemas de tratamiento para mitigar el cambio climático, tratando las aguas residuales domésticas con soluciones basadas en la naturaleza, ante el probable aumento de las temperaturas es eficiente y muy significativo.
Guidelines for completing the ADVANCE metadata form: a FAIR enabling resource for biodiversity monitoring data
Authors: Menger Juliana , Magagna Barbara , Henle Klaus , Harpke Alexander , Frenzel Mark , Rick Johannes , Wiltshire Karen , Grimm-Seyfarth Annegret 
Published: April 2024

Within the scope of the Helmholtz Metadata Collaboration, the ADVANCE project &ndash; Advanced metadata standards for biodiversity survey and monitoring data: supporting of research and conservation &ndash; aimed at supporting rich metadata generation with interoperable metadata standards and semantic artifacts that facilitate data access, integration and reuse across terrestrial, freshwater and marine realms.
To this end, we revised, adapted and expanded existing metadata schemas, vocabularies and thesauri to build a FAIR metadata schema and a metadata entry form built on it for users to provide their metadata instances focused on biodiversity monitoring data. The schema is FAIR because it is both machine-interpretable and follows domain-relevant community standards. This report provides a general overview of the project results and instructions on how to access, re-use and complete the metadata form.
Two new species and one new record of Ischnothyreus Simon, 1893 (Araneae, Oonopidae) from China
Authors: Song Chenxue , Tong Yanfeng , Bian Dongju , Zhang Zhisheng 
Published: April 2024

Ischnothyreus Simon, 1893 is a large genus of oonopid spiders that currently contains 126 species, amongst which, 28 have been recorded in China.
Two new Ischnothyreus species, Ischnothyreus daheling Tong & Zhang, sp. nov. and Ischnothyreus longyang Tong & Zhang, sp. nov., are described, based on specimens collected from Yunnan Province and Ischnothyreus velox Jackson, 1908 is recorded in China for the first time, based on material collected from Guangxi Province. All three species are illustrated.
Assurance R.C. vie privée
Authors: Rondao Alface Anthony 
Published: April 2024

Un mineur de 12 ans effectue une marche arrière non autorisée avec un véhicule sur un parking et heurte un véhicule en stationnement. Pendant ces quelques secondes, son oncle, qui le gardait, avait été ranger le caddie, à quelques mètres de là. Il avait laissé l’enfant seul dans le véhicule. Cela engendre-t-il l’application de la clause joyriding de l’assurance R.C. vie privée des parents ou s’agit-il plutôt d’un défaut de surveillance dans le chef de l’oncle qui avait la garde du mineur ?
L’appropriation discursive de la parole de la femme. Le cas des fatwas
Authors: Benidir Faïza 
Published: April 2024

Dans la perspective d’observer ce qu’il se passe, d’un point de vue linguistique, quand des « hommes » parlent à la place des « femmes » sur des sujets qui les concernent directement, cet article tente d’explorer les enjeux du procédé énonciatif de « parler à la place des autres » (Paveau 2016). Ici, il est abordé le contexte de domination rattaché à l’activité de l’émission des avis juridico-religieux musulmans (les fatwas ) lorsqu’elle est menée exclusivement par des mouftis hommes dans le cadre de la discussion des questions qui concernent spécifiquement les femmes. L’objectif de cet article est d’exposer comment la prise de parole des hommes à la place des femmes est, malgré son objectivité et neutralité axiologique postulées, imprégnée de connotations culturelles, de projections d’imaginaires et d’intégration de stéréotypes en rapport avec la femme et contribue à véhiculer celles-ci. Il montre que dans certaines fatwas la parole des femmes est en quelques sorte détournée ou déjouée pour faire valoir la position de l’autorité religieuse, représentée par le moufti.