bluuebunny/crossref_metadata_2025_split huggingface dataset:
Digital preservation of classical gardens at the San Su Shrine
Authors: Guo Li , Ma Wenjing , Gong Xueqian , Zhang Deshun , Zhai Zhigao , Li Mengjia 
Published: February 2024

Abstract
Chinese classical gardens, an essential part of World Cultural Heritage, are well exemplified by Xishu Garden as a notable branch of this tradition. This research focuses on the San Su Shrine—a quintessential example of Xishu Garden—and explores the application of digital technologies in the commemorative research and quantitative preservation of these gardens. By integrating terrestrial laser scanning and terrestrial digital photogrammetry, we acquired quantitative data and constructed digital models to innovate upon the methodological approach to garden conservation. The innovation of this study is its analysis of Xishu Garden’s commemorative spaces through both temporal and spatial dimensions. 1) Temporally, this study examines the evolution and stratification of the garden's commemorative elements across various historical periods. 2) Spatially, it explores the interconnectedness of commemorative elements within the garden's buildings, rockery stones, water landscape and plant landscape. This dual-faceted approach yields novel insights and methods for assessing the universal value of the commemorative aspects of Xishu Garden. Moreover, it promotes the application of digital technology in the study and preservation of Xishu and other Chinese classical gardens.
Successful management of an atrio-esophageal fistula after atrial fibrillation ablation: a case report
Authors: Hachiro Kohei , Takashima Noriyuki , Matsuoka Kentaro , Takebayashi Katsushi , Kaida Sachiko , Tani Masaji , Suzuki Tomoaki 
Published: February 2024

Abstract
Background
Atrio-esophageal fistula is a rare but still a catastrophic complication of radiofrequency ablation of atrial fibrillation. We report a successful case of atrio-esophageal fistula with right posterolateral thoracotomy and right femoral cannulation of cardiopulmonary bypass.

Case presentation
A 67-year-old man underwent radiofrequency ablation for atrial fibrillation. Nineteen days later, he developed cerebral infarction, and computed tomography showed air in the left atrium. He was transferred to our hospital for surgery. The upper body was placed in the left lateral decubitus position, and the lower body was placed in the left hemilateral decubitus position. The surgical approach was a right posterolateral thoracotomy in the 5th intercostal space. At first, the esophagus was transected at the diaphragm and tracheal carina levels. Then, an arterial line was inserted into the right common femoral artery and venous line into the right common femoral vein. Three U-shaped sutures of 3-0 polypropylene were placed to stop bleeding from the atrium. The esophagus was removed while snaring the 3-0 polypropylene sutures. There were two holes in the esophagus. Four drains were placed to clean the repaired site. After chest closure, the patient was placed supine. Cervical esophagostomy and enterostomy were performed. Gastric tube reconstruction via the retrosternal route was performed on postoperative day 28, and the patient was transferred to another hospital for rehabilitation on postoperative day 99.

Conclusions
It is important to thoroughly discuss with esophageal surgeon how to reach the heart and esophagus, and how to reconstruct the esophagus later.
First-Line Nivolumab Plus Chemotherapy for Advanced Gastric, Gastroesophageal Junction, and Esophageal Adenocarcinoma: 3-Year Follow-Up of the Phase III CheckMate 649 Trial
Authors: Janjigian Yelena Y. , Ajani Jaffer A. , Moehler Markus , Shen Lin , Garrido Marcelo , Gallardo Carlos , Wyrwicz Lucjan , Yamaguchi Kensei , Cleary James M. , Elimova Elena , Karamouzis Michalis , Bruges Ricardo , Skoczylas Tomasz , Bragagnoli Arinilda , Liu Tianshi , Tehfe Mustapha , Zander Thomas , Kowalyszyn Ruben , Pazo-Cid Roberto , Schenker Michael , Feeny Kynan , Wang Rui , Lei Ming , Chen Clara , Nathani Raheel , Shitara Kohei 
Published: February 2024

Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned co-primary or secondary analyses are not yet available. Clinical Trial Updates provide an opportunity to disseminate additional results from studies, published in JCO or elsewhere, for which the primary end point has already been reported. We report 3-year efficacy and safety results from the phase III CheckMate 649 trial. Patients with previously untreated advanced or metastatic gastroesophageal adenocarcinoma were randomly assigned to nivolumab plus chemotherapy or chemotherapy. Primary end points were overall survival (OS) and progression-free survival (PFS) by blinded independent central review (BICR) in patients whose tumors expressed PD-L1 combined positive score (CPS) ≥5. With 36.2-month minimum follow-up, for patients with PD-L1 CPS ≥5, the OS hazard ratio (HR) for nivolumab plus chemotherapy versus chemotherapy was 0.70 (95% CI, 0.61 to 0.81); 21% versus 10% of patients were alive at 36 months, respectively; the PFS HR was 0.70 (95% CI, 0.60 to 0.81); 36-month PFS rates were 13% versus 8%, respectively. The objective response rate (ORR) per BICR was 60% (95% CI, 55 to 65) with nivolumab plus chemotherapy versus 45% (95% CI, 40 to 50) with chemotherapy; median duration of response was 9.6 months (95% CI, 8.2 to 12.4) versus 7.0 months (95% CI, 5.6 to 7.9), respectively. Nivolumab plus chemotherapy also continued to show improvement in OS, PFS, and ORR versus chemotherapy in the overall population. Adding nivolumab to chemotherapy maintained clinically meaningful long-term survival benefit versus chemotherapy alone, with an acceptable safety profile, supporting the continued use of nivolumab plus chemotherapy as standard first-line treatment for advanced gastroesophageal adenocarcinoma.
Split Bregman quantum noise removal algorithm for 3D reconstruction of neutron computed tomography image
Authors: Zhu Tengfei , Liu Yang , Luo Zhi , Ouyang Xiaoping 
Published: February 2024

Abstract
The low intensity of the neutron source for neutron computed tomography (CT) results in a long acquisition time for a single projection, which causes the neutron projection data to contain a large amount of quantum noise. Quantum noise will degrade the quality of neutron CT reconstruction images. Therefore, an efficient quantum noise removal algorithm must be used in CT reconstruction. In this paper, an efficient quantum noise removal algorithm for neutron CT 3D image reconstruction is proposed by analysing classical image processing algorithms and quantum image processing algorithms, which employs the maximum likelihood expectation maximization to reconstruct the image and split Bregman algorithm to solve for the total variation (MLEM-SBTV). Experimental results show that MLEM-SBTV performs well in removing quantum noise and reconstructing the detailed structure of images.
Prioritizing Patient Experiences in the Management of Diabetes and Its Complications: An Endocrine Society Position Statement
Authors: Kalyani Rita R , Allende-Vigo Myriam Z , Antinori-Lent Kellie J , Close Kelly L , Das Sandeep R , Deroze Phyllisa , Edelman Steven V , El Sayed Nuha A , Kerr David , Neumiller Joshua J , Norton Anna 
Published: February 2024

Abstract
Diabetes can be an arduous journey both for people with diabetes (PWD) and their caregivers. While the journey of every person with diabetes is unique, common themes emerge in managing this disease. To date, the experiences of PWD have not been fully considered to successfully implement the recommended standards of diabetes care in practice. It is critical for health-care providers (HCPs) to recognize perspectives of PWD to achieve optimal health outcomes. Further, existing tools are available to facilitate patient-centered care but are often underused. This statement summarizes findings from multistakeholder expert roundtable discussions hosted by the Endocrine Society that aimed to identify existing gaps in the management of diabetes and its complications and to identify tools needed to empower HCPs and PWD to address their many challenges. The roundtables included delegates from professional societies, governmental organizations, patient advocacy organizations, and social enterprises committed to making life better for PWD. Each section begins with a clinical scenario that serves as a framework to achieve desired health outcomes and includes a discussion of resources for HCPs to deliver patient-centered care in clinical practice. As diabetes management evolves, achieving this goal will also require the development of new tools to help guide HCPs in supporting PWD, as well as concrete strategies for the efficient uptake of these tools in clinical practice to minimize provider burden. Importantly, coordination among various stakeholders including PWD, HCPs, caregivers, policymakers, and payers is critical at all stages of the patient journey.
Smaller body size under warming is not due to gill-oxygen limitation in a cold-water salmonid
Authors: Lonthair Joshua K. , Wegner Nicholas C. , Cheng Brian S. , Fangue Nann A. , O'Donnell Matthew J. , Regish Amy M. , Swenson John D. , Argueta Estefany , McCormick Stephen D. , Letcher Benjamin H. , Komoroske Lisa M. 
Published: February 2024

ABSTRACT
Declining body size in fishes and other aquatic ectotherms associated with anthropogenic climate warming has significant implications for future fisheries yields, stock assessments and aquatic ecosystem stability. One proposed mechanism seeking to explain such body-size reductions, known as the gill oxygen limitation (GOL) hypothesis, has recently been used to model future impacts of climate warming on fisheries but has not been robustly empirically tested. We used brook trout (Salvelinus fontinalis), a fast-growing, cold-water salmonid species of broad economic, conservation and ecological value, to examine the GOL hypothesis in a long-term experiment quantifying effects of temperature on growth, resting metabolic rate (RMR), maximum metabolic rate (MMR) and gill surface area (GSA). Despite significantly reduced growth and body size at an elevated temperature, allometric slopes of GSA were not significantly different than 1.0 and were above those for RMR and MMR at both temperature treatments (15°C and 20°C), contrary to GOL expectations. We also found that the effect of temperature on RMR was time-dependent, contradicting the prediction that heightened temperatures increase metabolic rates and reinforcing the importance of longer-term exposures (e.g. &gt;6 months) to fully understand the influence of acclimation on temperature–metabolic rate relationships. Our results indicate that although oxygen limitation may be important in some aspects of temperature–body size relationships and constraints on metabolic supply may contribute to reduced growth in some cases, it is unlikely that GOL is a universal mechanism explaining temperature–body size relationships in aquatic ectotherms. We suggest future research focus on alternative mechanisms underlying temperature–body size relationships, and that projections of climate change impacts on fisheries yields using models based on GOL assumptions be interpreted with caution.
Per capita sperm metabolism is density dependent
Authors: Potter Ashley E. , White Craig R. , Marshall Dustin J. 
Published: February 2024

ABSTRACT
From bacteria to metazoans, higher density populations have lower per capita metabolic rates than lower density populations. The negative covariance between population density and metabolic rate is thought to represent a form of adaptive metabolic plasticity. A relationship between density and metabolism was actually first noted 100 years ago, and was focused on spermatozoa; even then, it was postulated that adaptive plasticity drove this pattern. Since then, contemporary studies of sperm metabolism specifically assume that sperm concentration has no effect on metabolism and that sperm metabolic rates show no adaptive plasticity. We did a systematic review to estimate the relationship between sperm aerobic metabolism and sperm concentration, for 198 estimates spanning 49 species, from protostomes to humans from 88 studies. We found strong evidence that per capita metabolic rates are concentration dependent: both within and among species, sperm have lower metabolisms in dense ejaculates, but increase their metabolism when diluted. On average, a 10-fold decrease in sperm concentration increased per capita metabolic rate by 35%. Metabolic plasticity in sperm appears to be an adaptive response, whereby sperm maximize their chances of encountering eggs.
Prediction of Morbidity and Mortality After Esophagectomy: A Systematic Review
Authors: van Nieuw Amerongen M. P. , de Grooth H. J. , Veerman G. L. , Ziesemer K. A. , van Berge Henegouwen M. I. , Tuinman P. R. 
Published: February 2024

Abstract
Background
Esophagectomy for esophageal cancer has a complication rate of up to 60%. Prediction models could be helpful to preoperatively estimate which patients are at increased risk of morbidity and mortality. The objective of this study was to determine the best prediction models for morbidity and mortality after esophagectomy and to identify commonalities among the models.

Patients and Methods
A systematic review was performed in accordance to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement and was prospectively registered in PROSPERO (https://www.crd.york.ac.uk/prospero/, study ID CRD42022350846). Pubmed, Embase, and Clarivate Analytics/Web of Science Core Collection were searched for studies published between 2010 and August 2022. The Prediction model Risk of Bias Assessment Tool was used to assess the risk of bias. Extracted data were tabulated and a narrative synthesis was performed.

Results
Of the 15,011 articles identified, 22 studies were included using data from tens of thousands of patients. This systematic review included 33 different models, of which 18 models were newly developed. Many studies showed a high risk of bias. The prognostic accuracy of models differed between 0.51 and 0.85. For most models, variables are readily available. Two models for mortality and one model for pulmonary complications have the potential to be developed further.

Conclusions
The availability of rigorous prediction models is limited. Several models are promising but need to be further developed. Some models provide information about risk factors for the development of complications. Performance status is a potential modifiable risk factor. None are ready for clinical implementation.
Clinical and psychopathological features of the course and outcome of the first psychotic episode.
Authors: Bazhora Yuri , Gudz Valentyn , Mozgova Valentina , Usychenko Kateryna , Shvets Nikol 
Published: February 2024

Recently it has been established that cytokines are involved in the regulation of the body’s defense reactions in response to a pathogen and form an independent system for regulating homeostasis. The aim of this work is to study the relationship of the polymorphic marker TNFα (rs1800620) with its quantitative content and the degree of liver fibrosis in patients with various chronic hepatitis (VHC, VHB, VHB+C). The 82 patients with chronic hepatitis B, 62 patients with hepatitis B+C, and 100 patients with chronic hepatitis C were examined. GGTNFα (rs1800620) genotype is protective for patients with various viral hepatitis, and the GATNFα (rs1800620)and AATNFα (rs1800620)genotypes are profibrogenic for patients with chronic hepatitis B, chronic hepatitis B+C and chronic hepatitis C, respectively, since a high degree of fibrosis than in carriers of the homozygous GGTNFα (rs1800620)genotype. It is possible that the rate of fibrosis progression is influenced not only by the qualitative content of TNFα, but also by a certain genotype.
Single-Product Assemble-to-Order Systems with Exogenous Lead Times
Authors: Muharremoglu Alp , Yang Nan , Geng Xin 
Published: February 2024

Efficient Algorithm for Base Stock Policy Optimization in Single-Product Assemble-to-Order Systems with Stochastic Lead Times Single-product assemble-to-order systems can be commonly observed in industrial settings. For example, firms targeting a niche market often choose to offer a single product; moreover, sole-product rollout is usually a preferable business strategy for manufacturers promoting a brand-new product or trying to penetrate a new market. However, maintaining an effective inventory management for those systems is a notoriously difficult problem, especially when the order lead times exhibit stochastic patterns. In “Single-Product Assemble-to-Order Systems with Exogenous Lead Times,” Muharremoglu, Yang, and Geng investigate the case with a special type of stochastic lead time and utilize a certain analysis technique to develop an efficient algorithm for the performance evaluation of base stock policies. In addition, efficiently computable upper and lower bounds are proved based on the key idea of the algorithm. Extensive numerical studies show that the heuristics and the approximation methods developed from those bounds perform well in base stock optimization.
'DIE PETROLEUMINSELN': PÓS-COLONIALISMO E A QUESTÃO JUDAICA NA DRAMATURGIA DE LION FEUCHTWANGER
Authors: Coelho Luiz Henrique Ernesto 
Published: February 2024

O autor alemão Lion Feuchtwanger é amplamente reconhecido por sua escrita romanesca, sobretudo por seus romances históricos. Sua obra, no entanto, aponta para uma relevante produção dramática, ainda em sua juventude. A peça Die Petroleuminseln (1925) aborda questões como o racismo ambiental e o preconceito de gênero, ao narrar a história de Deborah Gray. Outro ponto tratado é a aparência da personagem – retrato do estereótipo imposto aos judeus – e sua intrínseca relação com o desejo de poder da protagonista. Tal configuração de elementos narrativos revela a necessidade posterior do autor de sair de sua terra natal. Nesta investigação, busca-se alinhar tal produção a questões então pioneiras como o ideário pós-colonialista atravessado pelo Ecocriticismo e a ligação produzida por Feuchtwanger entre judaísmo e gênero. Procura-se também iluminar alguns pontos, como o exílio do autor enquanto consequência desse conjunto de fatores e a influência de Bertolt Brecht em sua produção literária.
Compartir el amor: las Antígonas de Simone Weil y María Zambrano
Authors: Basili Cristina 
Published: February 2024

El artículo presenta un estudio comparativo de la figura de Antígona en las obras de Simone Weil y María Zambrano con el fin de poner de relieve el entramado teórico-político que surge de sus interpretaciones. Cabe, por tanto, no solo convergencias y discontinuidades en sus lecturas, sino también la búsqueda compartida, a través de una original compenetración entre místicay política, de una ampliación del espectro semántico de la política cuyo clímax reside en la valorización de la pasión extática del amor.
El ego cartesiano como reducto de la negación
Authors: Morales Guerrero Julio Armando 
Published: February 2024

En la obra de Descartes se verifica que la razón construye la realidad por vía de negación, limitando lo indeterminado e infinito desde la finitud; reduciendo gra dualmente lo complicado y oscuro a lo simple. Al desplegar las consecuencias del prin cipio lógico de identidad que rige al entendimiento, el valor del infinito que desde la Antigüedad griega fue negativo pasa a ser positivo. El problema del infinito aflora ante la soledad del cogito, surgida en el itinerario que en uso de la libertad trazan las Medi taciones acerca de la filosofía primera. De este modo, tiene lugar una convergencia de la filosofía especulativa y la filosofía práctica, ya que para Descartes el error deja de ser un acto del entendimiento solo y pasa a involucrar a la libertad. El error lógico que constituye la autorreferencia, según lo explica Bertrand Russell, trata de ser evitado por Descartes con el recurso al dios infinito en un plano ontológico distinto del que ocupa el Ser en la tradición metafísica que viene de la Antigüedad.
L’exercici de la ment oberta
Authors: Oms Sergi 
Published: February 2024

Aquest article explora les propostes més rellevants al voltant de la noció de ment oberta presents en la filosofia contemporània. Després d’un petit recorregut his tòric, el qual permet establir alguns dels components bàsics de la noció de ment oberta, l’article presenta el context teòric actual de la discussió: l’epistemologia de virtuts. Es distingeixen dos tipus de teories de la ment oberta i es donen raons per centrar-se en un d’ells, del qual se’n presenten críticament els tres casos més rellevants en la discussió actual. L’article presenta una discussió de quins són els reptes més rellevants als quals les teories de la ment oberta s’han d’enfrontar i n’extreu algunes conclusions que tenen a veure, sobretot, amb les interrelacions que es donen entre les virtuts epistèmiques i la noció de saviesa. L’article acaba amb dos apunts al voltant de la relació entre l’exercici de la ment oberta i l’educació, els quals s’analitzen a la llum de la discussió anterior: el primer, gira al voltant de la possibilitat d’ensenyar l’exercici de la ment oberta i, el segon, reflexiona sobre la compatibilitat d’aquest exercici amb l’educació.