bluuebunny/crossref_metadata_2025_split huggingface dataset:
Complementarism versus pluralism: are they different and does it matter?
Authors: Zhu Zhichang 
Published: February 2006

AbstractResearch on systems methodology has recently undertaken a wholesale transformation from ‘complementarism’ to ‘pluralism’, in presentation if not in spirit. This can be seen as an institutional/structurational process in the search by researchers for legitimate knowledge claims that are embedded in a particular historical, geographical and intellectual context in which (1) the paradigm (in)commensurability debate dominated social sciences and (2) postmodernist thinking gained overwhelming legitimating power. Systems methodology research needs to heighten its sensitivity toward institutional forces and institutionalization processes if it is to be productively conducted and beneficially applied. Copyright © 2006 John Wiley & Sons, Ltd.
Roadmapping as a way of knowledge management for supporting scientific research in academia
Authors: Ma Tieju , Liu Shu , Nakamori Yoshiteru 
Published: February 2006

AbstractMotorola Inc. first introduced the concept of a ‘roadmap’ in the 1970s as a kind of strategic planning tool. This paper argues that roadmapping can also be a useful way to manage knowledge in academia and to support scientific research. By applying the principles of interactive planning methodology, this paper puts forward a new methodology for making personal academic research roadmaps as a way of knowledge management in academia. This methodology is composed of six phases: forming groups, explanation from knowledge coordinators, description of present situation, current status and idealized design reports from every member, research and study schedules, and implementation and control. After introducing the approach, a case study describing the application of the methodology at the Japan Advanced Institute of Science and Technology is given. Copyright © 2006 John Wiley & Sons, Ltd.
Reflections on the new agoras project: a report on a Fuschl conversation
Authors: Espinosa Angela , Umpleby Stuart 
Published: February 2006

AbstractThe New Agoras Project is the result of the leadership of Bela H. Banathy in encouraging ideal‐seeking conversations in many venues, including the Fuschl conversations held for several years in Fuschl, Austria, under the sponsorship of the International Federation for Systems Research. In April 2002 one of the conversations in Fuschl was devoted to the New Agoras Project. Doug Walton and Patricia Gill had participated in earlier meetings on the New Agoras Project and so led the conversation. The co‐authors of this paper were new to discussions of the New Agoras Project but were familiar with other similar efforts in several countries. This paper is a reflection on the conversation that occurred in Fuschl. It compares the New Agoras Project with the work of the Institute of Cultural Affairs and lists websites and other work that we believe are related to the intent of the New Agoras Project. Copyright © 2006 John Wiley & Sons, Ltd.
La5Al3Ni2 – an Intermetallic Phase Observed upon Crystallization of La50Al25Ni25 Metallic Glass
Authors: Leineweber A. , Nitsche H. 
Published: February 2006

AbstractThe yet unknown intermetallic phase La5Al3Ni2 was obtained by partially crystallizing amorphous La50Al25Ni25 at 550 K (further heating above 600 K leads to irreversible disappearance of this phase), and its crystal structure was determined from X‐ray powder diffraction data. The crystal structure of the La5Al3Ni2 phase constitutes a new structure type (Cmcm, a = 14.231Å, b = 6.914Å, c = 10.460Å, oC40) and is built from [Al3Ni2] chains surrounded by La atoms. In the ternary system La‐Al‐Ni La5Al3Ni2 is located on the section La50Al50−nNin (0 ≤ n ≤ 50) with the binary compounds LaAl and LaNi as end members. Strikingly, also the crystal structures of the end members can be conceived as chain structures with Al and Ni chains surrounded by La, respectively.
Struktur‐Eigenschafts‐Beziehung von Cu5Pb6O3Cl11, einer gut Kupferionen leitenden Verbindung
Authors: Langecker Carsten , Andoura Karina , Keller Hans‐Lothar , Oldag Thorsten 
Published: February 2006

AbstractStructure‐Behaviour‐Relation of Cu5Pb6O3Cl11, a Good Solid State Ionic Conductor for Cu+‐IonsA new compound within the group of coin metal lead(II) oxide halides is found and characterized by X‐ray single crystal structure determination in a temperature range from 120 K to 400 K. Cu5Pb6O3Cl11 shows a new crystal type structure with a = 21.098(4) Å, b = 10.233(2) Å, c = 12.224(2) Å, β = 124.08(3)°, Z = 4 and space group C 2/c (No. 15) at 120 K. There are found isolated oxidic chains built of OPb4 tetrahedra beside columnar areas consisting of CuCl. In this halidic partial structure are a lot of empty and partially occupied Cl4‐tetrahedra. This structural characteristic seems to be source of a very good conductivity of copper ions, like in microscopic and nanoscaled composites of Al2O3 and AgI.
Chlor(trifluorphosphan)gold(I): [Au(PF3)Cl]
Authors: Schödel Frauke , Bolte Michael , Wagner Matthias , Lerner Hans‐Wolfram 
Published: February 2006

AbstractChloro(trifluorophosphane)gold(I): [Au(PF3)Cl]X‐ray quality crystals of [Au(PF3)Cl] (orthorhombic, Pnma) are obtained from a toluene / pentane solution at 6 °C. According to the result of the X‐ray structural analysis, [Au(PF3)Cl] contains an almost linear F3P‐Au‐Cl unit. The shortest Au‐Au contacts between two of these units are 3.3495(9) Å.
Unidimensional Self‐assembling of {HgII[NNN(PhBr)2]2} through Metal‐η4‐arene π‐Interactions: Synthesis and X‐Ray Characterization of a Bis Diaryl Symmetric‐substituted Triazenide Complex Polymer of Mercury(II)
Authors: Hörner Manfredo , Manzoni de Oliveira Gelson , Boneberger Behm Mariana , Fenner Herton 
Published: February 2006

AbstractA solution of deprotonated 1,3‐bis(4‐bromophenyl)triazene reacts with Hg(CH3COO)2 in methanol / tetrahydrofurane to give yellow crystalline needles of {HgII[NNN(PhBr)2]2}n, a triazenide complex polymer of HgII with metal‐η2,η2‐arene π‐interactions, performed by coordinated single triazenide chains. The crystal structure of the new polymeric complex of HgII belongs to the monoclinic space group P21/n. The lattice of [HgII(BrPhNNNPhBr)2]n can be viewed as a one‐dimensional assembling of planar tectons [HgII(BrPhNNNPhBr)2] linked through metalocene alike HgII‐η2,η2‐arene π‐interactions along the crystallographic b axis.
Concerning the Reaction of the Betain‐Like Compound O2CC(PPh3)2 with Tungsten‐Carbonyl Derivatives; Preparation and Crystal Structures of [(CO)5W{η1‐O2C2(PPh3)2}] and [(CO)4W{η2‐O2C2(PPh3)2}]
Authors: Petz Wolfgang , Öxler Florian , Brand Andreas , Neumüller Bernhard 
Published: February 2006

AbstractThe carbodiphosphorane CO2 adduct O2CC(PPh3)2 (1a) reacts with [(CO)5W(THF)] and [(CO)3W(NCEt)3] to produce the complexes [(CO)5W{η1‐O2CC(PPh3)2}] (2) and [(CO)4W{η2‐O2CC(PPh3)2}] (3), respectively. Whereas in 2 the betain‐like ligand is coordinated at the tungsten atom in a monodentate manner, in 3 it acts as a chelating ligand with formation of a WO2C four‐membered ring. As a by‐product during the reaction with the acetonitrile adduct also some crystals of the hydrolysis product [HC(PPh3)2]2[W6O19] · 3C2H4Cl2 (4 · 3C2H4Cl2) were isolated. All compounds could be characterized by X‐ray analyses and the usual spectroscopic methods.
New Saccharinato/Ammonia Complexes of Nickel(II) and Zinc(II). A Structural and Spectroscopic Study
Authors: Williams Patricia A. M. , Ferrer Evelina G. , Baeza Natalia , Piro Oscar E. , Baran Enrique J. 
Published: February 2006

AbstractTwo new saccharinate/NH3 complexes of composition [Ni(sac)2(NH3)4] and [Zn(sac)2(NH3)2] were obtained and their crystal structures determined by single crystal X‐ray diffractometry. The elongated octahedral NiII complex crystallizes in the monoclinic P21/c space group with Z = 2 whereas the tetrahedral ZnII complex is triclinic (space group ${\rm P}{\bar 1}$ and Z = 2). For [Ni(sac)2(NH3)4] the magnetic moment and electron absorption spectrum were obtained and discussed. The infrared spectra of both complexes were also recorded and briefly commented.
Cycloarsanes (AsCF3)n (n = 4, 5) – Precursors for the Highly Reactive Diarsene F3CAs=AsCF3
Authors: Grobe Joseph , Karst Andreas , Krebs B. , Läge M. , Würthwein Ernst‐Ulrich 
Published: February 2006

AbstractTetrakis(trifluoromethyl) cyclotetraarsane (F3CAs)4 (2) was used to repeat the UV initiated [4+2]‐cycloaddition reaction of the diarsene F3CAs=AsCF3 (1) with cyclohexa‐1,3‐diene (CHD) and to isolate single crystals of the cycloadduct 4 for a X‐ray diffraction analysis. 4 crystallizes in the space group ${\rm P}{\bar 1}$ and contains the diarsene group in its E‐configuration. 2 was also applied for [2+2]‐cycloaddition reactions of 1 with tBuC≡P and MeC≡CNiPr2, but in contrast to positive results with (F3CP)4 the products were too labile for isolation. However, 2 was successfully used at room temperature as precursor for coordinating 1 as π‐donor ligand to the Pd(PPh3)2 complex fragment yielding η2‐bis(trifluoromethyl)diarsene‐bis(triphenylphosphane)‐palladium(0) 5, which was characterized by X‐ray diffraction of single crystals and by spectroscopic investigations (NMR, IR, MS). Attempts to prove the existence of the diarsene 1, generated by different methods, by spectroscopic studies very probably failed due to its extreme reactivity, not allowing the necessary concentrations for detection.Quantum chemical calculations of the stability of 1 with respect to dimerization, the stability of the [2+2]‐cycloadduct with 1‐di(isopropyl)aminopropyne and the energy difference between 4 and the 2,3‐dimethyl‐1,3‐butadiene cycloadduct of 1 were performed to understand the considerable differences between 1 and the related diphosphene F3CP=PCF3.
Synthesis, Crystal Structure and Thermal Behavior of Gadolinium Dicyanamide Dihydrate Gd[N(CN)2]3 · 2 H2O
Authors: Nag Abanti , Schnick Wolfgang 
Published: February 2006

AbstractGadolinium dicyanamide dihydrate Gd[N(CN)2]3 · 2 H2O was prepared by ion exchange in aqueous solution followed by evaporation of the solvent at room temperature. Gd[N(CN)2]3 · 2 H2O was characterized by single‐crystal structure analysis, FTIR spectroscopy and DSC analysis. In the crystal there are three crystallographically independent [N(CN)2]− ions and Gd3+ which are coordinated by six N atoms from six different [N(CN)2]− ions and two O atoms from two water molecules forming an irregular quadratic antiprism. Four H bonds have been identified in the structure of Gd[N(CN)2]3 · 2 H2O, two of them running to terminal N atoms and two to the bridging N atoms of dicyanamide ions (Gd[N(CN)2]3 · 2 H2O: P21/n (no. 14), a = 7.4845(15) Å, b = 11.529(2) Å, c = 13.941(3) Å, β = 93.98(3)°, Z = 4, 1948 reflections, 175 parameters, R1 = 0.0493). The DSC analysis indicates that Gd[N(CN)2]3 · 2 H2O looses the crystal water at temperatures around 130 – 140 °C forming anhydrous Gd[N(CN)2]3, the structure of which has been refined by the Rietveld method based on X‐ray powder diffraction data. Gd[N(CN)2]3 was found to be isotypic with Ln[N(CN)2]3 (Ln = La, Ce, Pr, Nd, Sm and Eu) which previously have been described in the literature.
Syntheses, Structures, and Magnetic Properties of Two Novel Cobalt(II) Coordination Polymers Constructed from Pyridine‐2,6‐dicarboxylic Acid N‐oxide (PDCO)
Authors: Wen Li‐Li , Tian Zheng‐Fang , Lin Jian‐Guo , Zhu Hui‐Zhen , Meng Qing‐Jin 
Published: February 2006

AbstractTwo new cobalt(II) coordination polymers, [Co(PDCO)(H2O)2]n (1) and [Co(PDCO)(bix)(2H2O)2·H2O]n (2) ( PDCO= pyridine‐2,6‐dicarboxylic acid N‐oxide, bix = 1,4‐bis(imidazol‐1‐ylmethyl)‐benzene) have been synthesized under hydrothermal conditions. Single‐crystal X‐ray analyses show that compound 1 is a 1D helical chainlike structure with 41 screw axes parallel to the crystallographic c‐axis and interchain hydrogen‐bonding interactions further result in a 3D framework; for compound 2, each bix ligand connects two Co1 atoms (or two Co2 atoms) to give a zigzag chain structure and these 1D chains are connected by offset face‐to‐face π···π and hydrogen bond interactions to generate a 3D architecture. The thermogravimetric analyses were investigated for 1 and 2. The determination of variable temperature magnetic susceptibilities indicates an antiferromagnetic interaction between the metal atoms for 1 and 2.
[Ho5(H2O)16(OH)2As6W64O220]25−, ein großes neuartiges Polyoxoanion aus trivakanten Keggin‐Fragmenten
Authors: Drewes Daniel , Piepenbrink Markus , Krebs Bernt 
Published: February 2006

Abstract[Ho5(H2O)16(OH)2As6W64O220]25−, a Large Novel Polyoxoanion from Trivacant Keggin FragmentsThe novel polyoxotungstate Na7K18[Ho5(H2O)16(OH)2As6W64O220] · 56 H2O (1) was synthesized in aqueous solution and characterized by X‐ray structure analysis, elemental analysis and IR spectroscopy. The anion in 1 represents one of the largest polyoxoanions known yet and exhibits an unusual arrangement of six Keggin units. It consists of six trivacant lacunary α‐B‐(AsW9O33)9− Keggin fragments which are connected by a bridging [Ho5W10(H2O)16(OH)2O22]29+ unit. The five HoIII atoms are coordinated by eight oxygen atoms, forming a square‐antiprism.
Structure and Mössbauer Study of the First Mixed‐Valence Iron Diphosphonate: $^{2}_{\infty}[\rm \{Fe^{II/III}(H_{2}O)_{2}\}\{Fe^{III/II}Cl\}_{2}(\mu_{4}-O_{3}P-C(OH)\{(CH_{2})_{4}NH_{3}\}-PO_{3})_{2}]\cdot4H_{2}O$
Authors: Abu‐Shandi Khalid , Winkler Heiner , Janiak Christoph 
Published: February 2006

AbstractThe title compound bis(μ4‐5‐ammonio‐1‐hydroxypentyl‐idene‐1,1‐bisphosphonato‐κ7O,O′,O″,Om,O′v,Ov,Ov′,Ov″)‐(diaquairon)‐di(chloroiron)(II/III)‐tetrahydrate was prepared by hydrothermal synthesis and consists of nets of corner sharing {FeO6} or {FeClO5} octahedra linked by {CPO3} tetrahedra. Neighboring layers interdigitate with their ammoniopentylidene tails and connect to a three‐dimensional network by N‐H···O and O(hydrate)‐H···O hydrogen bonds. The ligand [PO3‐C(OH){(CH2)4+NH3}‐PO3]3− is a zwitter‐ion of overall charge –3. Different from other known iron diphosphonates, which contain only either FeII or FeIII, the iron bisphosphonate here is found from Mössbauer‐Spectroscopy to be a trapped mixed‐valence system with FeII and FeIII disordered over both crystallographic sites Fe1 and Fe2 in what could be described as a coherent superposition of different states. At 4.2 K the FeIII is completely magnetically ordered.
Dimerization of New T‐shaped Hypervalent Organotellurium(II) Dihalides: Synthesis and Structural Characterization of (PyH)[mesTeIX] (Py = pyridine; mes = mesityl; X = Cl, Br, I)
Authors: Manzoni de Oliveira Gelson , Faoro Eliandro , Schulz Lang Ernesto , Casagrande Gleison Antonio 
Published: February 2006

Abstract[mesTe]2 reacts with iodine in toluene and further with (C5H6N)+X− (X = I, Br, Cl) to give (PyH)[mesTeI2] (1), (PyH)[mesTeIBr] (2) and (PyH)[mesTeICl] (3). The anionic fragments [(mes)TeI2] and [(mes)TeIBr] of 1 and 2 are assembled as dimers by reciprocal, secondary Te···X interactions, linked also to the pyridinium cations through μ‐NH···X bonding. The anion [(mes)TeICl]− (3) do not interact with neighboring anionic moieties, achieving also secondary NH···Cl bonding toward the pyridinium cation. The dimerization ability – with attaining of additional interionic hydrogen bridges – of 1 and 2 allow them to be viewed as partially “molecular” and as hypervalent compounds of TeII, for which the observed linearity of the I–Te–X system and the similarity of the Te–X bond distances are expected.
Molecular and Crystal Structures of Pentafluorophenyl‐platinum(II) Complexes with Bis(diphenylphosphino)methane, Bis(diphenylarsino)methane and 1,2‐Bis(diphenylarsino)ethane
Authors: Babai Arash , Deacon Glen B. , Erven Anja P. , Meyer Gerd 
Published: February 2006

AbstractThe X‐ray crystal structures of [PtCl2(dppm)], [Pt(C6F5)2L] (L = dppm (bis(diphenylphosphino)methane), dpam (bis(diphenylarsino)methane), dpae (bis(diphenylarsino)ethane)) and [PtCl(C6F5)(dpae)] show the complexes to be monomeric with chelating dipnictido ligands, and not alternatives with bridging ligands. In [Pt(C6F5)2(dpam)2], there are two unidentate diarsine ligands in a cis‐arrangement.
Synthesis and Structure of Potassium 1‐Benzylimidazole‐2‐carboxylate · 2/3Hydrate
Authors: Batten Michael P. , Canty Allan J. , Cavell Kingsley J. , Skelton Brian W. , White Allan H. 
Published: February 2006

AbstractThe title compound, K[bimCO2] · 2/3H2O (C11H19N2O2K · 2/3H2O), has been synthesized, and characterized by a single crystal X‐ray study; it has the grouping $\rm [K_{3}(bimCO_{2})_{3}(OH_{2})_{2}]_{(\infty/\infty)}$cross‐linked into a polymeric sheet in which potassium environments are diverse and unsymmetrical, containing six‐coordinate and seven‐coordinate geometries.
A geographical model of high species diversity
Authors: Tainaka Kei‐ichi , Itoh Yoshiaki , Yoshimura Jin , Asami Takahiro 
Published: February 2006

AbstractSeveral cases of high species diversity, for example in tropical rain forests, imply that speciation has been frequent or rapid. However, how speciation could proceed so frequently as to generate extraordinary diversity still remains unsolved, despite recent advancements of diverse theories of allopatric and sympatric speciation. This paper presents a theoretical model that demonstrates the process of frequent speciation by means of geographical fragmentation. We focus on allopatric speciation and explore the evolutionary effect of fragmentation and extinction of demes (subpopulations) in a widespread species or species group. After a large contagious population of a single species is fragmented into demes, extinction of some demes could result in isolation of multiple demes. Thus, several demes could become good species simultaneously through the process of allopatric speciation. We apply the random extinction method to this fragmentation process where demes become randomly extinct. The present model illustrates that frequent speciation could occur in communities where large environmental changes frequently take place.
Adrenomedullin in the rostral ventrolateral medulla inhibits baroreflex control of heart rate: a role for protein kinase A
Authors: Xu Yong , Krukoff Teresa L 
Published: February 2006

The rostral ventrolateral medulla (RVLM) is an essential vasomotor center in the brainstem which participates in maintaining resting levels of arterial pressure and for regulating baroreflex activity. We have demonstrated that microinjections of adrenomedullin (ADM), a vasoactive neuropeptide, into the RVLM cause increased resting mean arterial pressure (MAP) and heart rate (HR). However, the effect of ADM on baroreflex function remains unclear.
The purposes of the present study were to investigate the effect of ADM in the RVLM on the regulation of baroreflex activity and to identify the underlying mechanisms. Baroreflex curves were generated with intravenous injections of multiple doses of phenylephrine and nitroprusside. The upper and lower plateaus, reflex range, MAP at the midpoint of HR range (MAP50), and gain were evaluated before and after various microinjections were made into the RVLM of urethane‐anesthetized rats.
Microinjections of ADM decreased the upper plateau, reflex range, and gain, and increased MAP50, indicating that ADM in the RVLM impairs baroreflex function.
ADM22–52, a putative ADM receptor antagonist, significantly increased the baroreflex gain and upper plateau, demonstrating that endogenous ADM tonically inhibits the baroreflex. Coinjections of ADM22–52 with ADM blocked the ADM‐induced baroreflex responses.
ADM's effect was abolished with H‐89, a protein kinase A (PKA) inhibitor.
Our results show that ADM in the RVLM exerts an inhibitory effect on baroreflex activity via an ADM receptor‐mediated mechanism, and that activation of PKA is involved in this event.

British Journal of Pharmacology (2006) 148, 70–77. doi:10.1038/sj.bjp.0706698
Inhibition of fatty acid amide hydrolase produces analgesia by multiple mechanisms
Authors: Chang Leon , Luo Lin , Palmer James A , Sutton Steven , Wilson Sandy J , Barbier Ann J , Breitenbucher James Guy , Chaplan Sandra R , Webb Michael 
Published: February 2006

The reversible fatty acid amide hydrolase (FAAH) inhibitor OL135 reverses mechanical allodynia in the spinal nerve ligation (SNL) and mild thermal injury (MTI) models in the rat. The purpose of this study was to investigate the role of the cannabinoid and opioid systems in mediating this analgesic effect.
Elevated brain concentrations of anandamide (350 pmol g−1 of tissue vs 60 pmol g−1 in vehicle‐treated controls) were found in brains of rats given OL135 (20 mg kg−1) i.p. 15 min prior to 20 mg kg−1 i.p. anandamide.
Predosing rats with OL135 (2–60 mg kg−1 i.p.) 30 min before administration of an irreversible FAAH inhibitor (URB597: 0.3 mg kg−1 intracardiac) was found to protect brain FAAH from irreversible inactivation. The level of enzyme protection was correlated with the OL135 concentrations in the same brains.
OL135 (100 mg kg−1 i.p.) reduced by 50% of the maximum possible efficacy (MPE) mechanical allodynia induced by MTI in FAAH+/+mice (von Frey filament measurement) 30 min after dosing, but was without effect in FAAH−/− mice.
OL135 given i.p. resulted in a dose‐responsive reversal of mechanical allodynia in both MTI and SNL models in the rat with an ED50 between 6 and 9 mg kg−1. The plasma concentration at the ED50 in both models was 0.7 μM (240 ng ml−1).
In the rat SNL model, coadministration of the selective CB2 receptor antagonist SR144528 (5 mg kg−1 i.p.), with 20 mg kg−1 OL135 blocked the OL135‐induced reversal of mechanical allodynia, but the selective CB1 antagonist SR141716A (5 mg kg−1 i.p.) was without effect.
In the rat MTI model neither SR141716A or SR144528 (both at 5 mg kg−1 i.p.), or a combination of both antagonists coadministered with OL135 (20 mg kg−1) blocked reversal of mechanical allodynia assessed 30 min after dosing.
In both the MTI model and SNL models in rats, naloxone (1 mg kg−1, i.p. 30 min after OL135) reversed the analgesia (to 15% of control levels in the MTI model, to zero in the SNL) produced by OL135.

British Journal of Pharmacology (2006) 148, 102–113. doi:10.1038/sj.bjp.0706699
Inhibition of superoxide anion and elastase release in human neutrophils by 3′‐isopropoxychalconeviaa cAMP‐dependent pathway
Authors: Hwang Tsong‐Long , Yeh Shang‐Hsin , Leu Yann‐Lii , Chern Ching‐Yuh , Hsu Hui‐Chi 
Published: February 2006

Chalcone is abundantly present in the plant kingdom and has various biological activities such as anti‐inflammatory and antioxidant. In this study, the semisynthetic chalcone derivative, 3′‐isopropoxychalcone (H2O7D), was demonstrated to inhibit the generation of superoxide and the release of elastase, as well as to accelerate resequestration of cytosolic calcium in formyl‐L‐methionyl‐L‐leucyl‐L‐phenylalanine‐activated human neutrophils.H2O7D displayed no antioxidant or superoxide‐scavenging ability, and it failed to alter the subcellular NADPH oxidase activity.H2O7D induced a substantial increase in cAMP but not cGMP levels. The elevation of cAMP formation by H2O7D was inhibited by adenosine deaminase (ADA). Furthermore, The inhibitory effects of H2O7D were reversed by protein kinase (PK)A inhibitors, as well as ADA and a selective A2a‐receptor antagonist.H2O7D inhibited phosphodiesterase (PDE) activities, but it did not alter adenylyl cyclase and soluble guanylyl cyclase activities. These results show that the cAMP‐elevating effect of H2O7D results from the inhibition of PDE activity and not from the stimulation of cyclase function. Consistent with this, H2O7D potentiated the PGE1‐caused inhibitory effects and cAMP formation.In summary, these results indicate that the inhibitory effect of H2O7D is cAMP/PKA dependent, and that it occurs through inhibition of cAMP PDE, which potentiates the autocrine functions of endogenous adenosine. Inhibition of respiratory burst and degranulation in human neutrophils may give this drug the potential to protect against the progression of inflammation.British Journal of Pharmacology(2006)148, 78–87. doi:10.1038/sj.bjp.0706712