bluuebunny/crossref_metadata_2025_split huggingface dataset:
High‐dose cyclophosphamide without stem cell rescue for refractory multifocal motor neuropathy
Authors: Brannagan Thomas H. , Alaedini Armin , Gladstone Douglas E. 
Published: February 2006

AbstractPatients with multifocal motor neuropathy (MMN) respond to intravenous immune globulin (IVIg) and cyclophosphamide, although the benefit is not sustained. High‐dose cyclophosphamide can induce a remission in patients with autoimmune diseases, including chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). We describe a patient with refractory MMN who improved with high‐dose cyclophosphamide (50 mg/kg for 4 days) without stem cell rescue. Following treatment she discontinued IVIg. At a 6‐month examination, her strength had improved and she had regained the ability to write. High‐dose cyclophosphamide may be a successful treatment for patients with MMN refractory to other therapies. Muscle Nerve, 2006
Familial idiopathic hyper‐CK‐emia: An underrecognized condition
Authors: Capasso Margherita , De Angelis Maria Vittoria , Di Muzio Antonio , Scarciolla Oronzo , Pace Marta , Stuppia Liborio , Comi Giacomo Pietro , Uncini Antonino 
Published: February 2006

AbstractPersistent elevation of serum creatine kinase (CK) in individuals with normal neurological and laboratory examinations has been called idiopathic hyperCKemia (IH). IH has been reported in rare families and was recently ascribed to caveolin‐3 gene mutations. We retrospectively found that IH was familial in 13 of 28 subjects in whom serum CK was measured in relatives. These 13 families had a total of 41 subjects with IH, including six over 60 years of age. In eight families there was male‐to‐male transmission and a higher prevalence of males with hyperCKemia. Muscle biopsy in one member of all families was normal or showed minimal, nonspecific changes. Morphometric examination disclosed different patterns of changes in fiber size and distribution. Caveolin‐3 expression was normal and in five families molecular genetics excluded caveolin‐3 gene mutations. Our findings suggest that IH is familial in 46% of cases. Familial IH is a benign genetically heterogeneous condition that is autosomal‐dominant in at least 60% of cases, with a higher penetrance in men. Muscle Nerve, 2006
Levetiracetam suppresses long‐loop reflexes at the cortical level
Authors: Kofler Markus 
Published: March 2006

AbstractPosthypoxic coma is often associated with cortical and brainstem hyperexcitability. Five months following cardiopulmonary resuscitation after myocardial infarction and ventricular arrhythmia, a 47‐year‐old man presented with posthypoxic cerebral dysfunction, minimal responsiveness, severe spastic‐dystonic tetraparesis, and stimulus‐sensitive muscle spasms upon acoustic and sensory stimulation. Neurophysiological examination revealed increased long‐loop reflexes in abductor pollicis brevis muscle following median nerve stimulation at the wrist, consistent with cortical hyperexcitability. Exaggerated startle responses provided evidence of concomitant brainstem disinhibition. Levetiracetam up to 3,000 mg per day suppressed transcortical long‐loop reflexes in a dose‐dependent manner without concomitant suppression of the H‐reflex and only mild attenuation of the startle response. The present findings suggest a suppressive effect of levetiracetam on cortical neurons in the absence of a spinal effect on monosynaptic reflexes, and thus support the drug's efficacy in posthypoxic cortical hyperexcitability. Muscle Nerve, 2006
Minimum multiple message broadcast graphs
Authors: Harutyunyan Hovhannes A. 
Published: March 2006

AbstractMultiple message broadcasting is the process of multiple message dissemination in a communication network in whichmmessages, originated by one vertex, are transmitted to all vertices of the network. A graphGwithnvertices is called a m‐message broadcast graph if its broadcast time is the theoretical minimum.Bm(n) is the minimum number of edges in any m‐message broadcast graph onnvertices. An m‐message minimum broadcast graph is a broadcast graphGonnvertices havingBm(n) edges. This article presents several lower and upper bounds onBm(n). In particular, it is shown that modified Knödel graphs are m‐message broadcast graphs form≤ min⌊logn⌋,n− 2⌊logn⌋. From the Cartesian product of some broadcast graphs we obtain better upper bounds onBm(n), and in some cases we can prove thatBm(n) =O(n). The exact value ofB2(2k) is also established. © 2006 Wiley Periodicals, Inc. NETWORKS, Vol. 47(4), 218–224 2006
Studies of TL peaks recorded with hyperbolic heating function
Authors: Bhattacharya Manabesh 
Published: March 2006

AbstractFor the first time thermoluminescence peaks corresponding to a hyperbolic heating function are studied in a model which takes into account not only the existence of thermally disconnected deep traps but also their interactions with the conduction band through the capture of electrons. The predictions of the present model are compared with those of other existing models, which are special cases of the present one. It is found that the Kirsh method, which is always valid, is applicable to all the models considered in the present paper. The quality of simulation of glow peaks is further tested by a rigorous method of curve fitting. The strong variation of the order of kinetics in the different models considered is due to the shift of the order of kinetics with dose. (© 2006 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
TL and PL in BaSr(SO4)2:Eu mixed sulphate
Authors: Salah Numan , Sahare P. D. , Kumar Pratik 
Published: March 2006

AbstractA highly sensitive thermoluminescent (TL) phosphor based on BaSr(SO4)2:Eu has been developed. The phosphor was recrystallized from H2SO4 solution by evaporation. Photoluminescence studies of this mixed‐sulphate phosphor show that Eu is incorporated in the host in its divalent (emission at 383 nm) as well as trivalent (emissions at 575 and 731 nm) form due to 4f65d → 8S7/2 and 5D0 → 7Fj transitions, respectively. The intensity of the 383 nm band increases with increasing irradiation, while that of the 731 nm band decreases, showing Eu3+ → Eu2+ conversion. The TL glow curve of the BaSr(SO4)2:Eu material shows a single peak at 470 K along with a small shoulder at around 428 K. The relative intensities of these peaks are found to vary with γ‐ray exposure. The TL sensitivity of the mixed‐sulphate phosphor is nearly 2.5, 7 and 1.2 times higher than those of BaSO4:Eu, SrSO4:Eu and CaSO4:Dy phosphors, respectively. The annealing temperature and the impurity concentration effects are also studied. (© 2006 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Ab initio MO study of potential energy surface of NH2 with CN reaction
Authors: Du Benni , Zhang Weichao 
Published: March 2006

AbstractAn extensive quantum chemical study of the potential energy surfaces (PES) for the association reaction of NH2 with CN and the subsequent isomerization and dissociation reactions has been carried out using density functional theory (DFT)/B3LYP/6‐311++G(3df,2p) level of theory on both singlet and triplet states. The reaction mechanism on the triplet surface is more complicated than that on the singlet surface. A total of 19 isomers and 46 transition states have been identified and characterized on the triplet PES. Among them, IM2 (IM2a), IM3 (IM3a, IM3b), and IM10 are the lowest‐lying isomers with thermodynamic stability. Twenty available dissociation channels, depending on the different initial isomers, have been identified. On the singlet surface, only 12 isomers and 16 transition states have been found, and among them IM1(S) and IM2(S) are the lowest‐lying isomers. The higher isomerization and dissociation barriers on the singlet surface indicate that the addition and the subsequent reactions of NH2+CN are most likely to occur on the triplet PES because of the lower barriers. A prediction can be made for the possible mechanism explaining the production of H+HNCN. Besides HNCN, other major products are NH+HCN and NH+HNC, which are produced by direct dissociation reactions from triplet IM2 and IM3, respectively. © 2006 Wiley Periodicals, Inc. Int J Quantum Chem, 2006
Building or bodging? Attitudes to sustainability in UK public sector housing construction development
Authors: Hall Mark , Purchase David 
Published: March 2006

AbstractThe UK government has established an agenda for ‘greening’ government activity and, as it accounts for approximately 40% of all UK construction procurement, is actively encouraging sustainability initiatives in this particular sector. However, there have been criticisms of its approach. The UK government anticipates investing approximately £3 billion in the social housing sector over the next three years and, as a prelude to this, has asked the Housing Corporation to promote a raft of sustainable development initiatives. This paper draws on two tranches of data in order to examine the impact of the UK government's sustainability policy on the way the public sector procures housing construction. The first of these is the sustainability improvement targets from 143 public sector housing associations. The evidence from this first tranche of data suggests that sustainability is currently seen as a low priority and that government initiatives have yet to make a significant impact. The second tranche of data uses comments from housing association development managers to examine the reasons for this apparent lack of impact. This focuses on their views and opinions of sustainability as an issue in social housing development and enables inferences to be made about their attitudes to this issue. There has been criticism about the lack of progress so far seen and the results in this paper suggest that this criticism is justified. Copyright © 2006 John Wiley & Sons, Ltd and ERP Environment.
Care of the Self and Patient Participation in Genetic Discourse: A Foucauldian Reading of the Surgeon General's “My Family Health Portrait” Program
Authors: Bates Benjamin R. 
Published: February 2006

AbstractCritics of genetic discourse are concerned that deterministic and discriminatory views of genetics are increasingly becoming adopted. These views argue that current genetic discourse becomes a source of power whereby powerful institutions harm people with so‐called “bad” genes. This essay argues that current analyses of the power of genetics discourse are grounded in an improper reading that disempowers patients. Deploying Michel Foucault's concept “care of the self,” this essay claims that genetics discourse is better understood as a way that patients take on power through rhetoric rather than a force that has power over patients. Through a close reading of the “My Family Health Portrait” program, this paper argues that patients experience a process of “subjection” wherein they become agents of and objects of genetics discourse both. This alternative mode of analyzing the power of genetics discourse has implications for our collective understanding of the operations of the care of the self and the uses of genetic information that we propose.
Positive solutions of semilinear elliptic problems in unbounded domains with unbounded boundary
Authors: Cerami Giovanna , Molle Riccardo , Passaseo Donato 
Published: February 2006

This paper is concerned with the existence and multiplicity of positive solutions of the equation−\mathrm{\Delta }u + u = u^{p−1},2 < p < 2^{ \ast } = \frac{2N}{N−2}, with Dirichlet zero data, in an unbounded smooth domain\Omega \subset \mathbb{R}^{N}having unbounded boundary. Under the assumptions:(h_1)\ \exists \tau _{1},\tau _{2},…,\tau _{k} \in \mathbb{R}^+ \setminus \{0\},\ 1⩽k⩽N−2,\text{ such that }(x_{1},x_{2},…,x_{N}) \in \Omega \:\iff \:(x_{1},…,x_{i−1},x_{i} + \tau _{i},…,x_{N}) \in \Omega ,\:\forall i = 1,2,…,k,(h_2)\ \exists R \in \mathbb{R}^{ + }\! \setminus\! \{0\} \text{ such that }\mathbb{R}^{N} \!\setminus\! \Omega\! \subset\! \{(x_{1},x_{2},…,x_{N}) \in \mathbb{R}^{N}\text{:}\sum\limits _{j = k + 1}^{N}\! x_{j}^{2}⩽R^{2}\}the existence of at leastk + 1solutions is proved.RésuméDans cet article on étudie l'existence et la multiplicité de solutions positives pour l'équation−\mathrm{\Delta }u + u = u^{p−1},2 < p < 2^{ \ast } = \frac{2N}{N−2}, avec la condition de Dirichletu = 0sur∂Ω. Le domaine\Omega \subset \mathbb{R}^{N}est non borné et∂Ωest non borné aussi. En supposant que les conditions(h_1)\ \exists \tau _{1},\tau _{2},…,\tau _{k} \in \mathbb{R}^+ \setminus \{0\},\ 1⩽k⩽N−2,\text{ tels que }(x_{1},x_{2},…,x_{N}) \in \Omega \:\iff \:(x_{1},…,x_{i−1},x_{i} + \tau _{i},…,x_{N}) \in \Omega ,\:\forall i = 1,2,…,k,(h_2)\ \exists R \in \mathbb{R}^{ + }\! \setminus\! \{0\} \text{ tel que }\mathbb{R}^{N} \!\setminus\! \Omega\! \subset\! \{(x_{1},x_{2},…,x_{N}) \in \mathbb{R}^{N}\text{:}\sum\limits _{j = k + 1}^{N}\! x_{j}^{2}⩽R^{2}\}soient vérifiées, on démontre que le problème possède au moinsk + 1solutions.
Active Ras‐induced effects on skeletal myoblast differentiation and apoptosis are independent of constitutive PI3‐kinase activity
Authors: Karasarides M. , Dee K. , Schulman D. , Wolfman A. , Weyman C.M. 
Published: February 2006

Abstract23A2 myoblasts expressing GAP‐resistant, constitutively active G12V:H‐Ras (A2:G12V:H‐Ras myoblasts) display a transformed morphology and do not undergo mitogen‐deprivation‐induced differentiation or the associated apoptosis. To determine the phenotype induced by F156L:H‐Ras, a constitutively active mutant with enhanced nucleotide exchange activity rather than impaired GAP‐stimulated GTPase activity, myoblast cell lines were established that stably express F156L:H‐Ras at levels of H‐Ras comparable to the A2:G12V:H‐Ras myoblasts. These A2:F156L:H‐Ras myoblast cell lines do not possess a transformed morphology, and while differentiation and apoptosis are impaired, these processes are not abrogated as in the A2:G12V:H‐Ras myoblasts. Surprisingly, while expression of either G12V:H‐Ras or F156L:H‐Ras results in constitutive signaling through PI3‐kinase, only cells expressing G12V:H‐Ras additionally possess constitutive signaling through MAPK, and NFκB. Pharmacological abrogation of the Ras‐induced constitutive PI3‐kinase signal, however, is not responsible for the impaired differentiation or apoptosis in either A2:G12V:H‐Ras myoblasts or A2:F156L:H‐Ras myoblasts. Thus, our data suggest that a pathway distinct from those that signals through MAPK, NFκB or PI3‐kinase is responsible for the impaired differentiation and apoptosis in 23A2 skeletal myoblasts expressing constitutively active Ras.
Stress and tissue Doppler echocardiographic evidence of effectiveness of myoblast transplantation in patients with ischaemic heart failure
Authors: Biagini Elena , Valgimigli Marco , Smits Pieter C. , Poldermans Don , Schinkel Arend F.L. , Rizzello Vittoria , Onderwater‐ Emile E.M. , Bountioukos Manolis , Serruys Patrick W. 
Published: March 2006

AbstractBackgroundThere is experimental evidence that transplanting skeletal myoblasts (SM) into the post‐infarction myocardial scar improves regional and global left ventricular (LV) function.AimsTo evaluate short‐ and long‐term regional and global LV functional effects of percutaneously transplanted SM in patients with ischaemic heart failure.Methods and resultsTen patients (mean age 60 ± 10 years, 8 males) with dilated ischaemic cardiomyopathy underwent percutaneous injection of autologous myoblasts. Regional and global LV function was evaluated by 2‐dimensional echocardiography and tissue Doppler imaging (TDI) at rest and during low‐dose dobutamine infusion to assess contractile reserve. After a baseline examination, sequential follow‐ups were performed at 1, 3, and 6 months and 1 year. NYHA functional class decreased from 2.7 ± 0.5 to 1.9 ± 0.5 (p < 0.01) at one year. LV function and volumes at rest remained unchanged while contractile reserve significantly improved during follow‐up. At low‐dose dobutamine infusion, the peak systolic velocity in the regions of myoblasts injection significantly increased at TDI examination (from 7.7 ± 2.1 to 8.6 ± 1.8 cm/s, p = 0.02); LV ejection fraction improved (from 40 ± 9% to 46 ± 8%, p < 0.0001) and end‐systolic volumes decreased (from 56 ± 28 to 50 ± 25 ml/m2, p = 0.001) at 1 year.ConclusionIn patients with ischaemic heart failure, percutaneous injection of autologous myoblasts may improve regional and global LV systolic function during dobutamine infusion, at 1‐year follow‐up.
Brachytherapy technique for abdominal wall metastases of colorectal cancer: ultrasound-guided insertion of applicator needle and a skin preservation method
Authors: Kishi K. , Takifuji K. , Shirai S. , Sonomura T. , Sato M. , Yamaue H. 
Published: March 2006

Purpose: To report a technique of interstitial brachytherapy for the treatment of subcutaneous metastatic abdominal wall tumors. Material and Methods: We developed a brachytherapy technique consisting of ultrasound-guided insertion of applicator needles to avoid the organs at risk, such as intestines, and saline injection into the subcutaneous tissue between the tumor and the skin to decrease the skin dose. We encountered three patients with painful metastases from rectal carcinoma in the abdominal wall refractory to external radiotherapy. They were subjected to this brachytherapy with a single dose of 20 Gy. Results: The procedure was safely achieved in all three patients. Long-lasting pain reduction and tumor shrinkage was obtained without early or late complications. Conclusion: This interstitial brachytherapy technique seems to be feasible in the treatment of metastatic abdominal wall tumors.
Paloverde: an OpenGL 3D phylogeny browser
Authors: Sanderson Michael J. 
Published: February 2006

Abstract
Summary: Paloverde is a new program designed to help visualize the phylogenetic structure of moderately large trees—trees on the scale of 100–2500 leaf nodes. The program embeds the user in an interactive virtual 3D world in which a large tree presented in various layouts can be manipulated through a mouse interface. The program implements radial 2D layouts, and true 3D spiral, conical and hemispherical (i.e. truly ‘tree’-like) layouts. Subclades can be defined in the input file (using standard node-based definitions) and displayed collapsed as new leaf nodes, or left intact but annotated with names around the periphery of the tree. A search tool lets the user zoom to any selected leaf node. Paloverde is an open source project written in ANSI C using the OpenGL library for 3D visualization.
Availability: Source code, makefiles for Mac OS X and Linux and a compiled binary for Mac OS X are available at , along with a sample dataset.
Contact: mjsanderson@ucdavis.edu
The UCSC Known Genes
Authors: Hsu Fan , Kent W. James , Clawson Hiram , Kuhn Robert M. , Diekhans Mark , Haussler David 
Published: February 2006

Abstract
The University of California Santa Cruz (UCSC) Known Genes dataset is constructed by a fully automated process, based on protein data from Swiss-Prot/TrEMBL (UniProt) and the associated mRNA data from Genbank. The detailed steps of this process are described. Extensive cross-references from this dataset to other genomic and proteomic data were constructed. For each known gene, a details page is provided containing rich information about the gene, together with extensive links to other relevant genomic, proteomic and pathway data. As of July 2005, the UCSC Known Genes are available for human, mouse and rat genomes. The Known Genes serves as a foundation to support several key programs: the Genome Browser, Proteome Browser, Gene Sorter and Table Browser offered at the UCSC website. All the associated data files and program source code are also available. They can be accessed at . The genomic coverage of UCSC Known Genes, RefSeq, Ensembl Genes, H-Invitational and CCDS is analyzed. Although UCSC Known Genes offers the highest genomic and CDS coverage among major human and mouse gene sets, more detailed analysis suggests all of them could be further improved.
Contact: fanhsu@soe.ucsc.edu
A novel sensitive method for the detection of user-defined compositional bias in biological sequences
Authors: Kuznetsov Igor B. , Hwang Seungwoo 
Published: February 2006

Abstract
Motivation: Most biological sequences contain compositionally biased segments in which one or more residue types are significantly overrepresented. The function and evolution of these segments are poorly understood. Usually, all types of compositionally biased segments are masked and ignored during sequence analysis. However, it has been shown for a number of proteins that biased segments that contain amino acids with similar chemical properties are involved in a variety of molecular functions and human diseases. A detailed large-scale analysis of the functional implications and evolutionary conservation of different compositionally biased segments requires a sensitive method capable of detecting user-specified types of compositional bias.
Results: We present BIAS, a novel sensitive method for the detection of compositionally biased segments composed of a user-specified set of residue types. BIAS uses the discrete scan statistics that provides a highly accurate correction for multiple tests to compute analytical estimates of the significance of each compositionally biased segment. The method can take into account global compositional bias when computing analytical estimates of the significance of local clusters. BIAS is benchmarked against SEG, SAPS and CAST programs. We also use BIAS to show that groups of proteins with the same biological function are significantly associated with particular types of compositionally biased segments.
Availability: The software is available at
Contact: ikuznetsov@albany.edu
Supplementary information: Supplementary data are available at Bioinformatics online.
Mass Analysis Peptide Sequence Prediction (MAPSP)
Authors: Eisenacher Martin , de Braaf Jürgen , König Simone 
Published: February 2006

Abstract
Summary: The software tool MAPSP allows the combinatorial prediction of novel short peptides such as hormones with common sequence features. In addition, it assists in de novo sequencing in general. The tool was designed for use in conjunction with the analytical identification method of mass spectrometry (MS) and it can considerably speed-up the analysis of unknowns.
Availability: The web interface is freely available at
Contact: koenigs@uni-muenster.de
Algorithm to find gene expression profiles of deregulation and identify families of disease-altered genes
Authors: Prieto C. , Rivas M.J. , Sánchez J.M. , López-Fidalgo J. , De Las Rivas J. 
Published: February 2006

AbstractMotivation: Alteration of gene expression often results in up- or down-regulated genes and the most common analysis strategies look for such differentially expressed genes. However, molecular disease mechanisms typically constitute abnormalities in the regulation of genes producing strong alterations in the expression levels. The search for such deregulation states in the genomic expression profiles will help to identify disease-altered genes better.Results: We have developed an algorithm that searches for the genes which present a significant alteration in the variability of their expression profiles, by comparing an altered state with a control state. The algorithm provides groups of genes and assigns a statistical measure of significance to each group of genes selected. The method also includes a prefilter tool to select genes with a threshold of differential expression that can be set by the user ad casum. The method is evaluated using an experimental set of microarrays of human control and cancer samples from patients with acute promyelocytic leukemia.Availability: The method is implemented in an R package called AlteredExpression available in and will be included in the Bioconductor project.Contact: jrivas@usal.es