bluuebunny/crossref_metadata_2025_split huggingface dataset:
Progress, application and challenges of liver organoids
Authors: Sang Chen , Lin Jian , Ji Shuyi , Gao Qiang 
Published: March 2024

AbstractThe liver, the largest solid organ in the body, is susceptible to metabolic diseases and malignant tumors. Studying its physiological and pathological processes helps to optimize the clinical treatment. Organoids are a novel tool for studying physical development, disease mechanisms, and high-throughput drug screening due to their similarity in composition, structure, and function to internal organs. Recent studies have shown that stem cells, hepatocytes, or cholangiocytes can form “liver organoids” under the synergistic action of specific extracellular matrix and various signaling molecules. This review outlines techniques for generating liver organoids that maximally recapitulate the liver structure and functions in vitro and thoroughly discusses the customary applications of organoids derived from liver tissue, induced pluripotent stem cells (iPSCs) and liver tumors. In this review, a meticulous analysis is provided of the comparatively advanced culture systems used in the construction of liver cancer-derived organoids. Additionally, we reviewed the progress of liver organoids in disease modeling, drug efficacy, and toxicity evaluation, in hopes of generating innovative ideas for the research and applications of liver organoids.
Interrelationships Among the Rice Export Prices of Major Exporting Countries: In Search of the Leader and Followers
Authors: Mottaleb Khondoker Abdul , Durand-Morat Alvaro 
Published: March 2024

AbstractBy examining the econometric interrelationships of rice export prices of India, Thailand, Vietnam, Pakistan, the U.S., Argentina, Brazil, and Uruguay, this study examines the most influential rice-exporting countries in the international rice export market. The sampled countries are the source of more than 80% of the global rice exports. In the process, this study relies on online data portals of the United Nations and country-level sources for aromatic and non-aromatic rice export price information from India, Pakistan, and Thailand. This study employed the Prais-Winsten and Autoregressive Distributive Lag (ARDL) estimation processes with the error correction procedure. Combining the findings from both models, this study concludes that in terms of interactions, the non-aromatic long-grain rice price of the U.S., and the aromatic rice price of Pakistan are the most correlated prices in the international rice market. Considering the number of countries influenced by the price of a given country, our results indicate that Vietnam is the price leader in the non-aromatic long-grain market, followed by Argentina, Brazil, and India. India, the largest exporter, is the fourth top price leader. In the case of aromatic rice, Thailand is the absolute leader. Many countries in Asia and Africa rely on rice imports to meet domestic demand, where the food security situation is already precarious. Based on the findings, this study suggests closely monitoring rice production and export trends of Vietnam, Argentina, Brazil, India and Thailand to provide early warning when necessary to better manage supply shocks in the international rice market.
Mack’s estimator motivated by large exposure asymptotics in a compound poisson setting
Authors: Engler Nils , Lindskog Filip 
Published: March 2024

AbstractThe distribution-free chain ladder of Mack justified the use of the chain ladder predictor and enabled Mack to derive an estimator of conditional mean squared error of prediction for the chain ladder predictor. Classical insurance loss models, that is of compound Poisson type, are not consistent with Mack’s distribution-free chain ladder. However, for a sequence of compound Poisson loss models indexed by exposure (e.g., number of contracts), we show that the chain ladder predictor and Mack’s estimator of conditional mean squared error of prediction can be derived by considering large exposure asymptotics. Hence, quantifying chain ladder prediction uncertainty can be done with Mack’s estimator without relying on the validity of the model assumptions of the distribution-free chain ladder.
The origins and development of Article 16 of the Charter of fundamental rights
Authors: Hogan Hilary 
Published: March 2024

AbstractWhen the Charter of Fundamental Rights was published in 2000, it was the first time that an international human rights instrument had recognised the freedom to conduct a business. To understand how conducting a business came to occupy the status of a fundamental right, I undertake an examination of the drafting process of Article 16 in Section 2. Early drafts protected the freedom to pursue an occupation, before the freedom to conduct a business eventually became a freestanding entitlement. This was thanks to the influence of Convention members associated with the European People’s Party who were instrumental in ensuring Article 16 was added to the draft Charter. In Section 3, I critically assess the claim contained in the Explanations to the Charter that Article 16 was simply a codification of pre-existing entitlements deriving from the case law of the Court of Justice. In Section 4, I examine the impact of Article 16 Many of the limitations that constrain the scope of Article 16 have been weakened, or have not proved to be the limitations that were originally envisaged. The Court of Justice’s defence of select areas, such as consumer protection, has shielded the deregulatory potential of Article 16 from view. Yet Article 16 has had a real and damaging impact on workers’ rights across the Union. Protecting the freedom to conduct a business in Article 16 means that a remarkably broad range of actions taken in the course of running a business are now accepted as the exercise of a fundamental right.
WAND/SET THEORIES: A REALIZATION OF CONWAY’S MATHEMATICIANS’ LIBERATION MOVEMENT, WITH AN APPLICATION TO CHURCH’S SET THEORY WITH A UNIVERSAL SET
Authors: BUTTON TIM 
Published: March 2024

Abstract
Consider a variant of the usual story about the iterative conception of sets. As usual, at every stage, you find all the (bland) sets of objects which you found earlier. But you also find the result of tapping any earlier-found object with any magic wand (from a given stock of magic wands).
By varying the number and behaviour of the wands, we can flesh out this idea in many different ways. This paper's main Theorem is that any loosely constructive way of fleshing out this idea is synonymous with a ZF-like theory.
This Theorem has rich applications; it realizes John Conway's (1976) Mathematicians' Liberation Movement; and it connects with a lovely idea due to Alonzo Church (1974).
Navigating transformations: Climate change and international law
Authors: Mai Laura 
Published: March 2024

AbstractThe global climate crisis response envisioned by the Paris Agreement is commonly understood as demanding transformative change. International law, however, lacks a holistic conceptual framing for making sense of what such change would entail, how it might unfold, and who and what it will involve. Moreover, there has been little critical engagement with the question of what is at stake when invoking the notion of transformation. Contributing to the broader debate about what the climate crisis demands of international law, this article offers a critical conceptual appraisal of the notion of ‘transformation’. Conceptually, it describes transformative dynamics as processes which work towards radically different states of affairs that seem practically impossible under the status quo, but which could arguably be realized if different conditions were in place. Developing an ontology of transformative change, the article identifies heterogenous temporality, the actualization of impossible possibilities, and distributed engagement as three central features of transformations in climate crisis. Having laid the conceptual groundwork, the article then takes a critical turn and foregrounds unresolved tensions that run through transformation thinking. The aim here is to connect to critical discourses and show how these tensions can serve as entry points for international law to meaningfully engage with the notion of transformation. The article closes by offering some reflections on what engagement with the notion of transformation might mean for international law’s disciplinary identity, rationale, and sense of purpose.
Oppressive Even As It Inspires
Authors: Visser-Maessen Laura , Van den Berk Jorrit 
Published: March 2024

AbstractIn this article, we trace the evolution of the connections between Black America and (Black) Europe since the mid-twentieth century and the study thereof. We do so through the lens of ‘Black American centrality,’ referring to the ways in which perceptions of Black America serve as an outsized reference point in European understandings of race, ‘Blackness,’ and Black (European) emancipation struggles. This allows for exploring the dilemmas that the, at times overwhelming, visibility of ‘Black America’ poses to Black Europeans, particularly during the current moment of flourishing Black European culture, politics, and scholarship. In that context, we show how both U.S.- and Europe-based scholars of Black American history and Black European history have approached Black American-European connections differently. The article concludes with suggestions for how these fields can engage with each other to develop academic approaches that account for but do not privilege the position of Black Americans within diasporic exchanges in the North Atlantic region, which is currently an underexplored area in diaspora studies.
Practice versus perception: A discussion of the humanitarian principle of independence in the context of migration
Authors: Hoagland Nicole , Arias Cubas Magdalena 
Published: March 2024

AbstractThe principle of independence is central to the International Red Cross and Red Crescent Movement's work with and for migrants. Independence requires humanitarian actors to retain their autonomy and resist any interference that might divert them from acting according to the principles of humanity, impartiality and neutrality. Yet, in the face of increasing securitization of migration and instrumentalization of aid and migrants, independence – in practice and perception – cannot be assumed. Drawing from current debates and primary research by the Red Cross Red Crescent Global Migration Lab, this article examines existing challenges in upholding independence in migration contexts and outlines recommendations for action.
Absence of High Frequency Echoes From Ionosondes During the 23–25 April 2023 Geomagnetic Storm; What Happened?
Authors: Habarulema John Bosco , Zhang Yongliang , Matamba Tshimangadzo , Buresova Dalia , Lu Gang , Katamzi‐Joseph Zama , Fagundes Paulo Roberto , Okoh Daniel , Seemala Gopi 
Published: March 2024

AbstractWe report an unusual event on absence of high frequency (HF) echoes in ionosonde observations from the ionospheric F2 region during the geomagnetic storm of 23–25 April 2023. This event was observed in both southern and northern hemispheres over two stations, Grahamstown (33.3°S, 26.5°E), South Africa and Pruhonice (50.0°N, 14.6°E), Czech Republic. Significant O/N2 depletion over the stations was observed by TIMED/GUVI, indicating a strong negative ionospheric storm. This is unique since absence of echoes in ionosonde measurements is usually due to strong radio absorption in the ionosphere associated with solar flares. However, there was no flare activity during the periods of “absent” F2 HF echoes. On the other hand, the ionosonde detected echoes from E‐layer. TIEGCM simulation reproduced TIMED/GUVI O/N2 depletion and showed that NmE was larger than NmF2 on dayside over Pruhonice. TIMED/GUVI O/N2 also showed a clear spatial gradient in the O/N2 depleted regions, suggesting F‐region ionosphere was tilted. By estimating the critical frequency of the F2 layer using GNSS observations, we have shown that it wasn't possible for the ionospheric electron density to reach depletion levels prohibiting reflection of HF echoes from ionosondes. We suggest that this phenomena may have been caused by either (a) maximum electron density of E layer exceeding that of F2 layer and/or (b) ionospheric tilting which made the signals to be reflected far away from the ionosonde locations.
Quantifying the Electron Energy of Mars Aurorae Through the Oxygen Emission Brightness Ratio at 130.4 and 135.6 nm
Authors: Soret Lauriane , Hubert Benoît , Gérard Jean‐Claude , Jain Sonal , Chirakkil K. , Lillis R. , Deighan J. 
Published: March 2024

AbstractMars discrete aurorae are caused by accelerated electrons precipitating into the atmosphere and interacting with species such as atomic oxygen. However, the energy of the electrons causing these aurorae remains currently unclear: no simultaneous and concurrent measurements of electron analyzers and spectrometers have been performed so far, preventing from assessing the exact energy of the downgoing auroral electrons. Several auroral emissions have been observed so far on Mars, among which are two oxygen emissions in the far ultraviolet at 130.4 and 135.6 nm. In this study, we simulate the vertical distribution of these auroral oxygen emissions with an electron transport calculation coupled with a radiative transfer model to account for the optical thickness of the atmosphere for the 130.4‐nm triplet. We show that the brightness ratio of these oxygen emissions is independent of the downward electron energy flux and only slightly depends on the atomic oxygen atmospheric composition. In contrast, the brightness ratio is strongly related to the initial energy of the auroral electrons. Measuring the brightness ratio is therefore a unique tool to remotely estimate the energy of the electrons causing the Mars discrete aurorae. We compare our model results with observations from the Emirates Mars Ultraviolet Spectrometer on board the Emirates Mars Mission and find that electrons with typical energies of 250–300 eV are compatible with the observed ratio of 5.
Stochastic in Space and Time: 1. Characterizing Orographic Gradients in Mean Runoff and Daily Runoff Variability
Authors: Forte A. M. , Rossi M. W. 
Published: March 2024

AbstractMountain topography alters the phase, amount, and spatial distribution of precipitation. Past efforts focused on how orographic precipitation can alter spatial patterns in mean runoff, with less emphasis on how time‐varying runoff statistics may also vary with topography. Given the importance of the magnitude and frequency of runoff events to fluvial erosion, we evaluated whether orographic patterns in mean runoff and daily runoff variability can be constrained using the global WaterGAP3 water model data. Model runoff data are validated against observational data in the contiguous United States, showing agreement with mean runoff in all settings and daily runoff variability in settings where rainfall‐runoff predominates. In snowmelt‐influenced settings, runoff variability is overestimated by the water model data. Cognizant of these limitations, we use the water model data to develop relationships between mean runoff and daily runoff variability and how these are mediated by snowmelt fraction in mountain topography globally. A global analysis of topographic controls on hydroclimatic variables using a random forest model was ambiguous. Instead, relationships between topography and runoff parameters are better assessed at the mountain range scale. Rulesets linking topography to mean runoff and snowmelt fraction are developed for three mid‐latitude mountain landscapes—British Columbia, European Alps, and Greater Caucasus. Increasing topographic elevation and relief together leads to higher mean runoff and lower runoff variability due to the increasing contribution of snowmelt. The three sets of empirical relationships developed here serve as the basis for a suite of numerical experiments in our companion manuscript (Part 2, Forte & Rossi, 2024a, https://doi.org.10.1002/2023JF007327).
Predicting the Electrical Conductivity of Partially Saturated Frozen Porous Media, a Fractal Model for Wide Ranges of Temperature and Salinity
Authors: Luo Haoliang , Jougnot Damien , Jost Anne , Teng Jidong , Mendieta Aida , Lin Gang , Thanh Luong Duy 
Published: March 2024

AbstractThe quantitative determination of liquid water content and salinity in soils is crucial for the preservation of hydrological environments and engineering infrastructures, especially in frozen regions. Electrical conductivity, as a fundamental physical parameter in electrical and electromagnetic non‐destructive techniques, varies significantly with the physical and chemical properties, such as pore water conductivity, salinity, water saturation, and temperature. In this study, accounting for pore size and tortuous length following fractal distributions, we develop a new capillary bundle model for variation of electrical conductivity as a function of temperature in broad water saturation and salinity ranges. In this new model, we consider the contributions of bulk and surface conductivities to the total electrical conductivity. To test this model, a series of laboratory experiments were carried out for different initial water saturations and salinities using an electrical resistance apparatus and a nuclear magnetic resonance method. The experimental results show that unfrozen water saturation and ionic concentration affect the electrical conductivity of unsaturated frozen soils. Furthermore, the proposed model is capable of fitting the main trends of the experimental data from the literature and acquired in this study in unfrozen‐frozen conditions for different water contents. Relying on the proposed model, we also determine the expression of the apparent formation factor, which is significantly sensitive to porosity, water saturation, and temperature. The predicted values of the apparent formation factor also agree very well with the experimental data. This new capillary bundle model provides a new perspective in interpreting electrical monitoring to easily deduce changes in key variables in the cryosphere such as liquid water content and moisture gradients.
Investigating the spatiotemporal characteristics and medical response during the initial COVID-19 epidemic in six Chinese cities
Authors: Lan Li , Li Gang , Mehmood Muhammad Sajid , Xu Tingting , Wang Wei , Nie Qifan 
Published: March 2024

AbstractIn the future, novel and highly pathogenic viruses may re-emerge, leading to a surge in healthcare demand. It is essential for urban epidemic control to investigate different cities’ spatiotemporal spread characteristics and medical carrying capacity during the early stages of COVID-19. This study employed textual analysis, mathematical statistics, and spatial analysis methods to examine the situation in six highly affected Chinese cities. The findings reveal that these cities experienced three phases during the initial outbreak of COVID-19: “unknown-origin incubation”, “Wuhan-related outbreak”, and “local exposure outbreak”. Cities with a high number of confirmed cases exhibited a multicore pattern, while those with fewer cases displayed a single-core pattern. The cores were distributed hierarchically in the central built-up areas of cities’ economic, political, or transportation centers. The radii of these cores shrank as the central built-up area’s level decreased, indicating a hierarchical decay and a core–edge structure. It suggests that decentralized built environments (non-clustered economies and populations) are less likely to facilitate large-scale epidemic clusters. Additionally, the deployment of designated hospitals in these cities was consistent with the spatial distribution of the epidemic; however, their carrying capacity requires urgent improvement. Ultimately, the essence of prevention and control is the governance of human activities and the efficient management of limited resources about individuals, places, and materials through leveraging IT and GIS technologies to address supply–demand contradictions.
An isochronous stress ratio logarithmic strain curve based clay creep model considering the effects of hardening and damage
Authors: Wang Peng , Tang Yin , Ren Peng , Zhang Hua 
Published: March 2024

AbstractCreep is one of the typical mechanical properties of clay, and studying the creep mechanical properties of clay is of great significance to construction projects in clay sites. This study conducted creep tests on Chengdu clay and found that the soil mass underwent elastic deformation, decay creep deformation, steady-state creep deformation, and accelerated creep deformation. The isochronous stress ratio-logarithmic strain curves and their mathematical models were proposed to thoroughly analyze clay creep mechanical properties. Creep automatic feature points, such as linear elastic extreme point, initial yield point, long-term strength point, and plastic point, were identified on the curve. Considering the hardening and damage effects during creep loading, linear elastic and viscoelastic elements considering the time-dependent damage, a viscoplastic element considering the load hardening effect, and viscoplastic and plastic elements considering the load damage effect were established based on the element model and the Riemann–Liouville fractional derivative. Based on the mechanical properties of the whole clay creep process, the creep mechanical feature points, and the established element model, a clay creep model was proposed considering the hardening and damage effects. The rationality and regularity of the creep model were verified using the creep test data. This research accurately revealed the creep mechanical properties of clay and facilitated soil deformation prediction, thus providing technical guidance and references for construction projects in clay sites.