bluuebunny/crossref_metadata_2025_split huggingface dataset:
Studying online with special needs: A student perspective
Authors: Öhrstedt Maria , Käck Annika , Reierstam Helena , Ghilagaber Gebrenegus 
Published: April 2024

AbstractAs diversity is increasing in higher education, the number of students with disabilities (SWD) grows. In parallel, technological development and online education change the conditions for teaching and learning. Previous research indicates that the digitalisation provides both challenges and opportunities for equal participation. This study explores the experiences of SWD in online higher education, using the Communities of Inquiry model as a theoretical framework. A questionnaire with 6256 students (430 SWD) examines the differences and similarities between SWD and other students in online courses. The results show that SWD are a heterogeneous group with diverse needs and preferences, and that online education can offer both advantages and disadvantages for them. The main advantages are using technology to compensate for disabilities, enabling more equal participation, and the flexibility and convenience of online courses. The main challenges are difficulties in planning and self‐regulation, decreased motivation and increased stress, perceived uncertainties about examination requirements and proceedings and the unfulfilled need for interactive environments and feedback. The importance of faculty–student relationships is highlighted, and the significance of clarity and accessibility, feedback and interaction and flexibility and variation in creating inclusive online courses is emphasised. Implications for policy and practice are suggested.
Auction politics: Party competition and expansionary election promises
Authors: COSTELLO RORY 
Published: April 2024

AbstractParty competition sometimes resembles an auction, where parties seek to ‘buy’ elections through promises of economic largesse. In this article, I argue that whether parties engage in this practice will depend on political circumstances, such as the level of ideological competition. Incentives to promise more to voters will also vary depending on a party's electoral prospects: for parties that expect a significant level of government responsibility, promising too much is a risky strategy. I test these arguments by focusing on the spending commitments in party manifestos from 20 countries over the period 1945–2017. In line with expectations, parties tend to make more expansionary election pledges when ideological competition is more muted. In addition, left‐wing parties’ spending commitments are found to be influenced by their projected seat shares (based on opinion polls from before the start of the election campaign) relative to their competitors. Specifically, the stronger a left‐wing party's electoral prospects, the more fiscally conservative it tends to be, and vice versa.
Turnover importance: Operationalizing beta diversity to quantify the generalism continuum
Authors: Morley Lydia , Crain Benjamin J. , Krupnick Gary , Spalink Daniel 
Published: April 2024

Abstract

Generalization is difficult to quantify, and many classifications exist. A beta diversity framework can be used to establish a numeric measure of generalist tendencies that jointly describes many important features of species interactions, namely spatiotemporal heterogeneity. This framework is promising for studying generalized symbiotic relationships of any form.

We formulated a novel index, turnover importance (T). T describes spatiotemporal heterogeneity in interactor assemblages, an inherent feature of generalist relationships that is not captured by available metrics. We simulated the behaviour of T relative to other available metrics, calculated T for native North American orchid‐insect relationships, and tested correlations between T and eco‐geographic variables. We performed case studies to demonstrate applications of T for conservation and eco‐evolutionary studies.

T behaves predictably across simulations, and dynamically interacts with site number, gamma diversity, and species range sizes. T is moderately sensitive to sampling depth. Orchids with higher T scores occupy larger ranges and broader climatic niches.

Alternative interactor‐specific measures of generalism are best employed for local‐level community networks over short timespans. While these interactor metrics can assess use versus availability in local communities, T can be used to measure spatiotemporal patterns of variation in interactor assemblages across a focal species' range. This study provides a roadmap for future work focused on better understanding the patterns and consequences of generalized relationships.
From red tape to innovation: How does municipal government financing reform affect corporate R&D activities?
Authors: Wu Kai , Guo Dingyao 
Published: April 2024

AbstractWe evaluated the effect of an exogenous shock on municipal government debt financing reform on corporate innovation for a sample of Chinese‐listed firms from 2009 to 2019. The results show that this reform stimulates corporate innovation capacity, and the effect is more pronounced in non‐state‐owned and financially constrained firms. We attribute these findings to reduced external financing costs and the crowding‐out effect of a firm's real estate investment. Our results are robust to alternative variable definitions, model specifications, and estimation techniques and provide novel evidence concerning the role of municipal government financing in corporate innovation.
Social participation in Australian residential aged care: A human rights perspective
Authors: Morrison‐Dayan Rachel 
Published: April 2024

AbstractThe Royal Commission into Aged Care Quality and Safety emphasised the critical need for a human rights‐based approach to protect the rights of older people in the Australian aged care context, including ‘the right to social participation’. This topic is important because of the widespread social isolation and loneliness in Australian residential aged care. This article demonstrates how a human rights‐based framework can provide guidance to governments in approaching issues involving the protection of older people's need for social connection in aged care. In doing so, the article considers examples of how the Australian government can ensure choice of living arrangement, individualised support and access to community services and facilities in the residential aged care context to better protect the right to social participation.
Vision‐related quality of life in children: Cross‐cultural adaptation and test–retest reliability of the Danish version of the paediatric refractive error profile 2
Authors: Cerullo Chiara , Møller Flemming , Ewan Roy , Nørgaard Birgitte , Jakobsen Trine Moldrup 
Published: April 2024

AbstractPurposeTo translate and cross‐culturally adapt PREP2 into Danish and to investigate the face validity and reliability of Danish PREP2 through cognitive interviewing, Rasch and reliability analyses.MethodsThe Danish PREP2 was translated using a standardized procedure and then pretested following the Three‐Steps‐Interviews (TSTI) process. A total of 15 myopic children aged 7–14 wearing either orthokeratology lenses (ortho‐k) or single‐vision spectacles (SVS) were included in pretesting comprising cognitive interviews and Rasch analysis. Data from cognitive interviewing was analysed thematically according to Collins. Rasch analysis was used to pretest the psychometric properties in terms of person‐ and item‐fit statistics. Reliability was assessed via test–retest using Intra‐class correlation coefficient (ICC) in the CONTROL study population, which consisted of 60 Danish children aged 7–14 years wearing either ortho‐k or SVS.ResultsFifteen children participated in pilot studies comprising of cognitive interviewing and Rasch analysis and 44 out of 60 CONTROL children participated in test–retest reliability analysis. The translation process resulted in a Danish version of PREP2 corroborating the original. Pretesting highlighted issues in the contextualization of items and in marking responses. Thus, we introduced a digital format with help texts. Cognitive interviewing identified issues in the following Collins’ themes: comprehension (understanding of concepts), judgement (ambiguity of items) and response (selecting answers). Rasch analysis indicated that help texts were useful for clarifying context. The ICC was 0.77 (95% CI: 0.66–0.85).ConclusionsThe cross‐cultural adaptation of PREP2 was satisfactory and issues were identified and corrected through pretesting. The test–retest reliability showed substantial consistency. The instrument could be validated in a more generalizable setting in future studies. Trial registration: NCT03246464 (CONTROL study).
Wither the Greater Eurasian Partnership? Challenges from the East in an evolving world order
Authors: Kapoor Nivedita 
Published: April 2024

AbstractThe idea of the Greater Eurasian Partnership (GEP) has gained increasing currency in Russian foreign policy. The Russia–China partnership has been presented as its bedrock through a partnership between the Eurasian Economic Union and the Belt and Road Initiative, further expanding to include other regional powers from across East Asia, South Asia, Central Asia, and Middle East as well as nonwestern multilateral groupings (SCO, ASEAN). Given the centrality of Asia‐Pacific to this expansive concept, GEP has to deal with the challenges posed by the evolving regional geopolitics of the East and the rise of the Indo‐Pacific amidst heightened US–China rivalry. The paper seeks to conduct a policy review of GEP and its proposed development format in light of ongoing changes in the East to determine the likely future of the concept in a contested region that also remains at the center of this expansive Russian vision.
The local governance of COVID‐19: Lessons learned and ways forward in rural Bangladesh
Authors: Alam Edris , Han Xin , Islam Abu Reza Md. Towfiqul , Alvarez Elizabeth , Islam Md Kamrul , Dominey‐Howes Dale 
Published: April 2024

AbstractThis article investigates how a district administration in Bangladesh managed COVID‐19 pandemic risk governance. Interviews were conducted with civil administrators, local government representatives, and representatives from community‐based organizations and nongovernmental organizations. The findings indicate that, despite limited health facilities, widespread ignorance of the virus, joblessness among wage earners, economic pressure, and a massive outbreak of COVID‐19, the district administration has demonstrated its diligence, professionalism, local knowledge, and promptness in providing optimal public services through coordination and information sharing among all stakeholders. The synergies and coordination between local administration, security forces, and local government representatives were great challenges in implementing nonpharmaceutical polices and support programs.
Making donations work in crisis management: A contingent governance transition in philanthropy in Wuhan's COVID‐19 response
Authors: Han Xin , Gu Edward , Wang Zhenyu M. , Xiang Miao 
Published: April 2024

AbstractIn response to public complaints about the chaotic management of donations during the emergency, the site of the first identified COVID‐19 case, Wuhan (in central China), underwent a contingent governance transition. And given the public complaints about the disorganized management of donations during the early stage of emergency management in Wuhan in January 2020, local governments initiated a minor governance transition in philanthropy, involving multiple stakeholders such as public and private charities, as well as private enterprises. In contrast to the abundance of literature on governance actors such as the state, the market, and societal actors, this review discusses the changes in governance mechanisms using publicly available data from governmental websites, policy documents, and news reports. It examines a minor governance change in local philanthropy from hierarchical bureaucratic governance to embryotic non‐monocentric governance and to expedient collaborative/interactive governance. Moreover, it highlights the yet‐to‐be institutionalized characteristics of the newly emerging governance models in China, a country where the traditional mode of hierarchical governance is dominant. This article not only adds to the body of evidence on governance failures caused by monocentric bureaucracy, but it also contributes to the literature on public governance transition in China's philanthropic sector and the state‐society relations more broadly.
Peripheral T‐cell lymphomas expressing CD30 and CD15 expand the spectrum of anaplastic large cell lymphoma, ALK‐negative
Authors: Ganapathi Karthik A. , Nicolae Alina , Egan Caoimhe , Geng Huimin , Xi Liqiang , Pack Svetlana D. , McFadden Jason R. , Raffeld Mark , Jaffe Elaine S. , Pittaluga Stefania 
Published: April 2024

SummaryPeripheral T‐cell lymphomas (PTCL) are morphologically and biologically heterogeneous and a subset expresses CD30, including anaplastic large cell lymphomas (ALCL) and a minority of PTCL, not otherwise specified (PTCL, NOS). ALCL with ALK translocations (ALCL, ALK+) are readily identified by routine diagnostic methods, but differentiating ALCL without ALK translocation (ALCL, ALK−) and PTCL, NOS expressing CD30 (PTCL CD30+) can be challenging. Furthermore, rare PTCL co‐express CD30 and CD15 (PTCL CD30+CD15+); some resemble ALCL, ALK− while others resemble classic Hodgkin lymphoma. To explore the relationship between PTCL CD30+CD15+ and ALCL, ALK−, we analysed 19 cases of PTCL with CD30 expression, previously diagnosed as ALCL, ALK− (nine cases) and PTCL CD30+CD15+ (10 cases) for DUSP22/IRF4 rearrangements, coding RNA expression and selected transcriptome analysis using the NanoString nCounter gene expression analysis platform. Unsupervised clustering showed no clear segregation between ALCL, ALK− and PTCL CD30+CD15+. Three cases previously classified as PTCL CD30+CD15+ showed DUSP22/IRF4 rearrangements, favouring a diagnosis of ALCL, ALK−. Our results suggest that cases previously designated PTCL CD30+CD15+, likely fall within the spectrum of ALCL, ALK−; additionally, a subset of ALCL, ALK− with DUSP22/IRF4 rearrangement expresses CD15, consistent with previous reports and expands the immunophenotypic spectrum of this lymphoma subgroup.
Mixed histiocytic neoplasms: A multicentre series revealing diverse somatic mutations and responses to targeted therapy
Authors: Friedman Joshua S. , Durham Benjamin H. , Reiner Anne S. , Yabe Mariko , Petrova‐Drus Kseniya , Dogan Ahmet , Pulitzer Melissa , Busam Klaus J. , Francis Jasmine H. , Rampal Raajit K. , Ulaner Gary A. , Reddy Ryan , Yeh Randy , Hatzoglou Vaios , Lacouture Mario E. , Rotemberg Veronica , Mazor Roei D. , Hershkovitz‐Rokah Oshrat , Shpilberg Ofer , Goyal Gaurav , Go Ronald S. , Abeykoon Jithma P. , Rech Karen , Morlote Diana , Fidai Shiraz , Gannamani Vedavyas , Zia Maryam , Abdel‐Wahab Omar , Panageas Katherine S. , Rosenblum Marc K. , Diamond Eli L. 
Published: April 2024

SummaryHistiocytic neoplasms are diverse clonal haematopoietic disorders, and clinical disease is mediated by tumorous infiltration as well as uncontrolled systemic inflammation. Individual subtypes include Langerhans cell histiocytosis (LCH), Rosai–Dorfman–Destombes disease (RDD) and Erdheim–Chester disease (ECD), and these have been characterized with respect to clinical phenotypes, driver mutations and treatment paradigms. Less is known about patients with mixed histiocytic neoplasms (MXH), that is two or more coexisting disorders. This international collaboration examined patients with biopsy‐proven MXH with respect to component disease subtypes, oncogenic driver mutations and responses to conventional (chemotherapeutic or immunosuppressive) versus targeted (BRAF or MEK inhibitor) therapies. Twenty‐seven patients were studied with ECD/LCH (19/27), ECD/RDD (6/27), RDD/LCH (1/27) and ECD/RDD/LCH (1/27). Mutations previously undescribed in MXH were identified, including KRAS, MAP2K2, MAPK3, non‐V600‐BRAF, RAF1 and a BICD2‐BRAF fusion. A repeated‐measure generalized estimating equation demonstrated that targeted treatment was statistically significantly (1) more likely to result in a complete response (CR), partial response (PR) or stable disease (SD) (odds ratio [OR]: 17.34, 95% CI: 2.19–137.00, p = 0.007), and (2) less likely to result in progression (OR: 0.08, 95% CI: 0.03–0.23, p < 0.0001). Histiocytic neoplasms represent an entity with underappreciated clinical and molecular diversity, poor responsiveness to conventional therapy and exquisite sensitivity to targeted therapy.
Seasonality and consumer confidence
Authors: Zélity Balázs 
Published: April 2024

ABSTRACTThis research empirically investigates whether consumer confidence is affected by seasonal daylight fluctuations. Cross‐country panel regressions are run with two different datasets. It is found that both solar elevation and sunlight duration positively affect consumer confidence. The presence of country and year‐by‐month fixed effects as well as controls for the business cycle help rule out alternative explanations. A one standard deviation increase in solar elevation or sunlight duration is associated with a 0.03–0.04 SD increase in consumer confidence.
Differential contributions of G protein‐ or arrestin subtype‐mediated signalling underlie urocortin 3‐induced somatostatin secretion in pancreatic δ cells
Authors: Wang Kai‐Yu , Gao Ming‐Xin , Qi Hai‐Bo , An Wen‐tao , Lin Jing‐Yu , Ning Shang‐Lei , Yang Fan , Xiao Peng , Cheng Jie , Pan Wei , Cheng Qiu‐xia , Wang Jin , Fang Le , Sun Jin‐Peng , Yu Xiao 
Published: April 2024

AbstractBackground and PurposePancreatic islets are modulated by cross‐talk among different cell types and paracrine signalling plays important roles in maintaining glucose homeostasis. Urocortin 3 (UCN3) secreted by pancreatic β cells activates the CRF2 receptor (CRF2R) and downstream pathways mediated by different G protein or arrestin subtypes in δ cells to cause somatostatin (SST) secretion, and constitutes an important feedback circuit for glucose homeostasis.Experimental ApproachHere, we used Arrb1−/−, Arrb2−/−, Gsfl/fl and Gqfl/fl knockout mice, the G11‐shRNA‐GFPfl/fl lentivirus, as well as functional assays and pharmacological characterization to study how the coupling of Gs, G11 and β‐arrestin1 to CRF2R contributed to UCN3‐induced SST secretion in pancreatic δ cells.Key ResultsOur study showed that CRF2R coupled to a panel of G protein and arrestin subtypes in response to UCN3 engagement. While RyR3 phosphorylation by PKA at the S156, S2706 and S4697 sites may underlie the Gs‐mediated UCN3‐ CRF2R axis for SST secretion, the interaction of SYT1 with β‐arrestin1 is also essential for efficient SST secretion downstream of CRF2R. The specific expression of the transcription factor Stat6 may contribute to G11 expression in pancreatic δ cells. Furthermore, we found that different UCN3 concentrations may have distinct effects on glucose homeostasis, and these effects may depend on different CRF2R downstream effectors.Conclusions and ImplicationsCollectively, our results provide a landscape view of signalling mediated by different G protein or arrestin subtypes downstream of paracrine UCN3‐ CRF2R signalling in pancreatic β‐δ‐cell circuits, which may facilitate the understanding of fine‐tuned glucose homeostasis networks.
Role of protein kinase A and A kinase anchoring proteins in buffering and compartmentation of cAMP signalling in human airway smooth muscle cells
Authors: Sherpa Rinzhin T. , Moshal Karni S. , Agarwal Shailesh R. , Ostrom Rennolds S. , Harvey Robert D. 
Published: April 2024

Background and PurposeIn human airway smooth muscle (hASM) cells, not all receptors stimulating cAMP production elicit the same effects. This can only be explained if cAMP movement throughout the cell is restricted, yet the mechanisms involved are not fully understood. Phosphodiesterases (PDEs) contribute to compartmentation of many cAMP responses, but PDE activity alone is predicted to be insufficient if cAMP is otherwise freely diffusible. We tested the hypothesis that buffering of cAMP by protein kinase A (PKA) associated with A kinase anchoring proteins (AKAPs) slows cAMP diffusion and that this contributes to receptor‐mediated, compartmentalized responses.Experimental ApproachRaster image correlation spectroscopy (RICS) was used to measure intracellular cAMP diffusion coefficients and evaluate the contribution of PKA–AKAP interactions. Western blotting and immunocytochemistry were used to identify the AKAPs involved. RNA interference was used to down‐regulate AKAP expression and determine its effects on cAMP diffusion. Compartmentalized cAMP responses were measured using fluorescence resonance energy transfer (FRET) based biosensors.Key ResultsCyclic AMP movement was significantly slower than that of free‐diffusion in hASM cells, and disrupting PKA–AKAP interactions significantly increased the diffusion coefficient. PKA associated with the outer mitochondrial membrane appears to play a prominent role in this effect. Consistent with this idea, knocking down expression of D‐AKAP2, the primary mitochondrial AKAP, increased cAMP diffusion and disrupted compartmentation of receptor‐mediated responses.Conclusion and ImplicationsOur results confirm that AKAP‐anchored PKA contributes to the buffering of cAMP and is consequential in the compartmentation of cAMP responses in hASM cells.
EGFR degraders in non‐small‐cell lung cancer: Breakthrough and unresolved issue
Authors: Shen Jiayi , Chen Liping , Liu Jihu , Li Anzhi , Zheng Lüyin , Chen Sheng , Li Yongdong 
Published: April 2024

AbstractThe epidermal growth factor receptor (EGFR) has been well validated as a therapeutic target for anticancer drug discovery. Osimertinib has become the first globally accessible third‐generation EGFR inhibitor, representing one of the most advanced developments in non‐small‐cell lung cancer (NSCLC) therapy. However, a tertiary Cys797 to Ser797 (C797S) point mutation has hampered osimertinib treatment in patients with advanced EGFR‐mutated NSCLC. Several classes of fourth‐generation EGFR inhibitors were consequently discovered with the aim of overcoming the EGFRC797S mutation‐mediated resistance. However, no clinical efficacy data of the fourth‐generation EGFR inhibitors were reported to date, and EGFRC797S mutation‐mediated resistance remains an “unmet clinical need.” Proteolysis‐targeting chimeric molecules (PROTACs) obtained from EGFR‐TKIs have been developed to target drug resistance EGFR in NSCLC. Some PROTACs are from nature products. These degraders compared with EGFR inhibitors showed better efficiency in their cellular potency, inhibition, and toxicity profiles. In this review, we first introduce the structural properties of EGFR, the resistance, and mutations of EGFR, and then mainly focus on the recent advances of EGFR‐targeting degraders along with its advantages and outstanding challenges.
How retributive motives shape the emergence of third‐party punishment across intergroup contexts
Authors: Marshall Julia , McAuliffe Katherine 
Published: April 2024

AbstractThis study examines how retributive motives—the desire to punish for the purpose of inflicting harm in the absence of future benefits—shape third‐party punishment behavior across intergroup contexts. Six‐ to nine‐year‐olds (N = 151, Mage = 8.00, SDage = 1.15; 54% White, 18% mixed ethnicities, 17% Asian American; 46% female; from the USA) could punish ingroup, outgroup, or non‐group transgressors by removing positive resources and allocating negative ones. Both punishments were described as retributive, yet allocating negative resources was perceived as more retributive than removing positive ones. We predicted that children would punish outgroups more so than ingroups and that this effect would be especially pronounced when punishment is perceived as particularly retributive. The results did not align with this prediction; instead, children similarly punished all agents.