bluuebunny/crossref_metadata_2025_split huggingface dataset:
A translation and validation of the French version of the Gothenburg Trismus Questionnaire 2 (F‐GTQ‐2)
Authors: Girod‐Roux Marion , Tuomi Lisa , Finizia Caterina , Beldjoudi Anaïs , Métayer Claire , Faraoni Floriane , Fiot Lucile , Buiret Guillaume 
Published: March 2024

AbstractBackgroundLimitation of mouth opening, widely known as trismus, is a major symptom altering quality of life in individuals presenting from temporomandibular joint disorder or head and neck cancer. A French‐language instrument addressing jaw opening limitation following treatment for head and neck cancer (HNC) or temporomandibular joint disorder (TMD) is lacking.ObjectiveThe aim of this study was to translate and validate the Gothenburg Trismus Questionnaire‐2 (GTQ‐2) into French.MethodsA French translation of the GTQ‐2 was performed according to established international guidelines, leading to the French‐GTQ‐2 (F‐GTQ‐2). The validation study included 154 participants with trismus (minimum interincisal opening of ≤35 mm) following treatment for TMD or HNC and 149 age‐matched participants without trismus. All participants completed the F‐GTQ‐2 and participants with trismus completed additional health‐related quality of life questionnaires to allow for analysis of convergent validity.ResultsThe F‐GTQ‐2 demonstrated retained psychometric properties with Cronbach's alpha values above 0.70 for the domains, jaw‐related problems, eating limitations, facial pain and somewhat lower for muscular tension (0.60). Mainly moderate correlations were found when comparing the F‐GTQ‐2 to other instruments, which was in line with the pre‐specified hypotheses, indicating satisfactory convergent validity. Discriminant validity was found with statistically significant differences in all domains of the F‐GTQ‐2 between trismus and non‐trismus participants.ConclusionThe F‐GTQ‐2 can be considered a reliable and valid instrument to assess jaw‐related difficulties in individuals with trismus due to HNC or TMD.
Peer sexual harassment, appearance esteem, and emotional problems: Testing a mediation model across early adolescence
Authors: Gattario Kristina Holmqvist , Vira Emily G. , Lunde Carolina , Skoog Therése 
Published: March 2024

AbstractThis study used a longitudinal sample of early adolescent boys and girls (ages 10–12; N = 1113) to test a theoretically and empirically informed model suggesting that exposure to peer sexual harassment (age 10) predicts more emotional problems (age 12), and that lower appearance esteem (age 11) mediates this relation. On the within‐person level, which is the level on which the processes theoretically should play out, we found no support for the proposed mediation model for boys or for girls. Unexpectedly, we found that following times of more exposure to peer sexual harassment than usual, early adolescents instead experienced higher appearance esteem and fewer emotional problems than usual. More research is needed to replicate and understand these unexpected findings.
Workers' moral hazard and private insurer effort in disability insurance
Authors: Koning Pierre , van Lent Max 
Published: March 2024

AbstractWhile it is well known that supplementary private Disability Insurance (DI) has the potential to increase workers' moral hazard, the extra coverage may also increase incentives for private insurers to reduce caseloads by means of prevention and reintegration activities. With unique administrative data on DI contracts of firms in the Netherlands, this paper aims to disentangle these worker and insurer responses to increased coverage. Supplementary insurance increases the insurers' incentive to lower disability risks, but in our setting it also creates an incentive for the insurers to facilitate partial work resumption of disabled workers who have earnings capacity. Using firm‐ and time‐fixed effects models on the absence and employment rates, we find that insurer effort counteracts workers' moral hazard.
The relationship between oral status and healthy aging in Chinese older adults: A community cohort study
Authors: Jilili Maitixirepu , Cheng Yan 
Published: March 2024

AbstractObjectivesIn recent years, there has been a growing academic interest in investigating the determinants of healthy aging. The main objective of this study was to investigate the association between oral status, as defined by tooth loss and denture use, and healthy aging among Chinese older adults over a four‐year duration.MethodsThe data were derived from the 2014 and 2018 waves of the Chinese Longitudinal Healthy Longevity Survey. Descriptive statistics and multivariate logistic regression analysis were employed for statistical analysis.ResultsThe results suggest that older adults with ≥20 natural teeth have a higher likelihood of experiencing healthy aging compared to those with fewer than 20 natural teeth. In the fully adjusted model, only older adults with ≥20 natural teeth demonstrated a higher rate of healthy aging compared to those with 0 natural teeth, with an OR (95% CI): 2.09 (1.54–2.84).ConclusionsThese results highlight the importance of maintaining ≥20 teeth for promoting healthy aging among Chinese older adults. Furthermore, wearing dentures can, to varying degrees, mitigate the adverse effects of tooth loss on healthy aging. Rehabilitative interventions, such as the utilization of dentures and other clinical strategies, play a pivotal role in enhancing the oral health status of older individuals.
Melatonin MT1 receptors regulate the Sirt1/Nrf2/Ho‐1/Gpx4 pathway to prevent α‐synuclein‐induced ferroptosis in Parkinson's disease
Authors: Lv Qian‐Kun , Tao Kang‐Xin , Yao Xiao‐Yu , Pang Meng‐Zhu , Cao Bing‐Er , Liu Chun‐Feng , Wang Fen 
Published: March 2024

AbstractParkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic (DA) neurons and aggregation of α‐synuclein (α‐syn). Ferroptosis, a form of cell death induced by iron accumulation and lipid peroxidation, is involved in the pathogenesis of PD. It is unknown whether melatonin receptor 1 (MT1) modulates α‐syn and ferroptosis in PD. Here, we used α‐syn preformed fibrils (PFFs) to induce PD models in vivo and in vitro. In PD mice, α‐syn aggregation led to increased iron deposition and ferroptosis. MT1 knockout exacerbated these changes and resulted in more DA neuronal loss and severe motor impairment. MT1 knockout also suppressed the Sirt1/Nrf2/Ho1/Gpx4 pathway, reducing resistance to ferroptosis, and inhibited expression of ferritin Fth1, leading to more release of ferrous ions. In vitro experiments confirmed these findings. Knockdown of MT1 enhanced α‐syn PFF‐induced intracellular α‐syn aggregation and suppressed expression of the Sirt1/Nrf2/Ho1/Gpx4 pathway and Fth1 protein, thereby aggravating ferroptosis. Conversely, overexpression of MT1 reversed these effects. Our findings reveal a novel mechanism by which MT1 activation prevents α‐syn‐induced ferroptosis in PD, highlighting the neuroprotective role of MT1 in PD.
Signature Dynamics of Development in Second Language Sociolinguistic Competence: Evidence From an Intensive Microlongitudinal Study
Authors: Wirtz Mason A. , Pfenninger Simone E. 
Published: March 2024

AbstractThis study is the first to explore microdevelopment in sociolinguistic evaluative judgments of standard German and Austro‐Bavarian dialect by adult second language learners of German by using dense time serial measurements. Intensive longitudinal data (10 observations per participant) were collected from four learners at approximately weekly intervals over 3 months. We employed generalized additive models with superimposed periods of significant change to identify rapid developmental phases in individual developmental trajectories. By triangulating these models with qualitative introspective and retrodictive interview data, we identified environmental and psychological stimuli for change. Learners evinced increasing and decreasing periods of significant change, independent of length of residence. Dynamic constellations of identity‐ and agency‐related variables alongside more intensive social interaction with target‐variety speakers contributed to significant changes. We discuss findings from a complexity perspective and advocate for microlongitudinal studies in variationist second language acquisition to better capture stimuli for change in learners’ emerging multivarietal repertoires.
Predictive factors for transition to conversion therapy in hepatocellular carcinoma using atezolizumab plus bevacizumab
Authors: Kikuchi Tatsuya , Takeuchi Yasuto , Nouso Kazuhiro , Kariyama Kazuya , Kuwaki Kenji , Toshimori Junichi , Iwado Shota , Moriya Akio , Hagihara Hiroaki , Takabatake Hiroyuki , Tada Toshifumi , Yasunaka Tetsuya , Sakata Masahiro , Sue Masahiko , Miyake Nozomi , Adachi Takuya , Wada Nozomu , Onishi Hideki , Shiraha Hidenori , Takaki Akinobu , Otsuka Motoyuki 
Published: March 2024

AbstractBackgroundTo identify predictive factors associated with successful transition to conversion therapy following combination therapy with atezolizumab and bevacizumab in the treatment of unresectable hepatocellular carcinoma (HCC).MethodsIn total, 188 patients with HCC, who received atezolizumab plus bevacizumab combination therapy as the first‐line chemotherapy, were studied. Patients who achieved complete response (CR) with systemic chemotherapy alone were excluded. Clinical factors possibly linked to successful transition to conversion therapy and the achievement of cancer‐free status were identified.ResultsFifteen (8.0%) patients underwent conversion therapy. In the conversion group, there was a significantly higher proportion of patients with Barcelona Clinic Liver Cancer (BCLC) stage A or B (73.3% versus [vs.] 45.1%; p = .03) and tended to have lower Child‐Pugh scores and alpha‐fetoprotein levels. Multivariate analysis revealed that BCLC stage was a predictive factor for the implementation of conversion therapy (A or B; odds ratio 3.7 [95% CI: 1.1–13]; p = .04). Furthermore, 10 (66.7%) patients achieved cancer‐free status and exhibited a smaller number of intrahepatic lesions at the start of treatment (3.5 vs. 7; p < .01), and a shorter interval between systemic chemotherapy induction and conversion therapy (131 vs. 404 days; p < .01). In addition, the rate of achieving cancer‐free status by undergoing surgical resection or ablation therapy was significantly higher (p = .03).ConclusionBCLC stage was the sole predictive factor for successful transition to conversion therapy when using combination therapy with atezolizumab and bevacizumab to treat HCC. Furthermore, a small number of intrahepatic lesions and early transition to conversion therapy were associated with the achievement of cancer‐free status.
A multi‐sectoral community development intervention has a positive impact on diet quality and growth in school‐age children in rural Nepal
Authors: Miller Laurie C. , Neupane Sumanta , Joshi Neena , Lohani Mahendra 
Published: March 2024

AbstractPoor diet quality (diet diversity and animal‐source food [ASF] consumption) during childhood negatively affects growth, development, behaviour and physiologic function in later life. Relatively less is known about the impact of poor diet on the growth of school‐age children compared to children <5 years of age, especially in low/middle‐income countries. A better understanding of delivery strategies for effective interventions to improve diet and hence growth in school‐age children is needed. A 36‐month longitudinal controlled impact evaluation in rural Nepal assessed the nutrition and growth of children <5 years of age in families assigned via community clusters to full package intervention (community development, training in nutrition [during pregnancy and for children <5 years] and livestock husbandry), partial package (training only) or control (no inputs). Concurrent data were collected prospectively (baseline plus additional four rounds) on school‐age children (5–8 years at baseline) in these households; the present study analysed findings in the cohort of school‐age children seen at all five study visits (n = 341). Diet quality improved more in the full package school‐age children compared to those in partial package or control households. full package children consumed more ASF (β +0.40 [CI 0.07,0.73], p < 0.05), more diverse diets (β +0.93 [CI 0.55,1.31], p < 0.001) and had better head circumference z‐scores (β +0.21 [CI 0.07,0.35], p < 0.01) than control children. In conclusion, a multi‐sectoral community development intervention was associated with improvements in diet and growth of school‐age children in rural Nepal even though the intervention focused on the diet of children <5 years of age. The diet and growth of school‐age children can be favourably influenced by community‐level interventions, even indirectly.
Yosemite toad (Anaxyrus canorus) transcriptome reveals interplay between speciation genes and adaptive introgression
Authors: Maier Paul A. , Vandergast Amy G. , Bohonak Andrew J. 
Published: March 2024

AbstractGenomes are heterogeneous during the early stages of speciation, with small ‘islands’ of DNA appearing to reflect strong adaptive differences, surrounded by vast seas of relative homogeneity. As species diverge, secondary contact zones between them can act as an interface and selectively filter through advantageous alleles of hybrid origin. Such introgression is another important adaptive process, one that allows beneficial mosaics of recombinant DNA (‘rivers’) to flow from one species into another. Although genomic islands of divergence appear to be associated with reproductive isolation, and genomic rivers form by adaptive introgression, it is unknown whether islands and rivers tend to be the same or different loci. We examined three replicate secondary contact zones for the Yosemite toad (Anaxyrus canorus) using two genomic data sets and a morphometric data set to answer the questions: (1) How predictably different are islands and rivers, both in terms of genomic location and gene function? (2) Are the adaptive genetic trait loci underlying tadpole growth and development reliably islands, rivers or neither? We found that island and river loci have significant overlap within a contact zone, suggesting that some loci are first islands, and later are predictably converted into rivers. However, gene ontology enrichment analysis showed strong overlap in gene function unique to all island loci, suggesting predictability in overall gene pathways for islands. Genome‐wide association study outliers for tadpole development included LPIN3, a lipid metabolism gene potentially involved in climate change adaptation, that is island‐like for all three contact zones, but also appears to be introgressing (as a river) across one zone. Taken together, our results suggest that adaptive divergence and introgression may be more complementary forces than currently appreciated.
Assessment of Mayaro virus vector competence of the mosquito Aedes aegypti (Linnaeus, 1762) populations in Argentine using dose–response assays
Authors: Beranek Mauricio Daniel , Giayetto Octavio , Fischer Sylvia , Diaz Adrián 
Published: March 2024

AbstractMayaro virus (MAYV; Alphavirus: Togaviridae) is an emerging pathogen in Latin America, causing fever and polyarthritis. Sporadic outbreaks of MAYV have occurred in the region, with reported human cases being imported to Europe and North America. Although primarily a risk for those residing in the Amazon basin's tropical forests, recent reports highlight that urbanization would increase the risk of MAYV transmission in Latin America. Urban emergence depends on human susceptibility and the ability of mosquitos like Aedes aegypti (Linnaeus, 1762) (Diptera: Culicidae) to transmit MAYV. Despite the absence of active MAYV transmission in Argentine, the risk of introduction is substantial due to human movement and the presence of Ae. aegypti in the region. This study aimed to evaluate the susceptibility of different Argentine Ae. aegypti populations to MAYV genotype L (MAYV‐L) using dose–response assays and determine barriers to virus infection, dissemination and transmission. Immature mosquito stages were collected in Buenos Aires, Córdoba and Rosario cities. Female Ae. aegypti (F2) were orally infected by feeding on five concentrations of MAYV‐L, ranging from 1.0 to 6.0 log10 PFU/mL. Abdomens, legs and saliva were analysed using viral plaque assays. Results revealed that MAYV‐L between infection and dissemination were associated with viral doses rather than the population origin. Infection rates varied between 3% and 65%, with a 50% infectious dose >5.5 log10 PFU/mL. Dissemination occurred at 39%, with a 50% dissemination dose of ~6.0 log10 PFU/mL. Dissemination among infected mosquitoes ranged from 60% to 86%, and transmission from disseminated mosquitoes ranged from 11% to 20%. Argentine Ae. aegypti populations exhibited a need for higher viral doses of MAYV‐L than those typically found in humans to become infected. In addition, only a small proportion of infected mosquitoes were capable of transmitting the virus. Understanding MAYV transmission in urban areas is crucial for public health interventions.
Huanglian‐banxia promotes gastric motility of diabetic rats by modulating brain‐gut neurotransmitters through MAPK signaling pathway
Authors: Chen Wei , Chen Qiong , Huang Jiayi , Shen Xianmin , Zhang Lurong , Jiang Guorong , Wu Tingting , Wang Fei , Cheng Xudong 
Published: March 2024

AbstractBackgroundGastric motility disorder is an increasingly common problem among people with diabetes. Neurotransmitters have been recognized as critical regulators in the process of gastric motility. Previous study has shown that herb pair huanglian‐banxia (HL‐BX) can improve gastric motility, but the underlying mechanism is still unclear. The aim of this study was to further investigate the role of HL‐BX in modulating brain‐gut neurotransmission to promote gastric motility in diabetic rats, and to explore its possible mechanism.MethodsThe diabetic rats were divided into five groups. Gastric emptying rate, intestinal propulsion rate, body weight, and average food intake were determined. Substance P (SP), 5‐ hydroxytryptamine (5‐HT), and glucagon‐like peptide −1 (GLP‐1) in the serum were measured by enzyme‐linked immunosorbent assay. Dopamine (DA) and norepinephrine (NE) in the brain were analyzed by high‐pressure liquid chromatography with a fluorescence detector. Protein expression of the tissues in the stomach and brain was determined by Western blot.Key ResultsHL‐BX reduced average food intake significantly, increased body weight, and improved gastric emptying rate and intestinal propulsion rate. HL‐BX administration caused a significant increase in SP, GLP‐1, and 5‐HT, but a significant decrease in DA and NE. Interestingly, HL‐BX regulated simultaneously the different expressions of MAPK and its downstream p70S6K/S6 signaling pathway in the stomach and brain. Moreover, berberine exhibited a similar effect to HL‐BX.ConclusionsThese results indicated that HL‐BX promoted gastric motility by regulating brain‐gut neurotransmitters through the MAPK signaling pathway. HL‐BX and MAPK provide a potential therapeutic option for the treatment of gastroparesis.
Brexit: Trade Diversion due to Trade Policy Uncertainty
Authors: Gutiérrez Eduardo , Lacuesta Aitor , Martín‐Machuca César 
Published: March 2024

AbstractThe paper quantifies how much of the reduction in Spanish trade flows with the UK after the 2016 Brexit referendum was diverted to other markets. To obtain reliable estimates of trade diversion we regress firm‐level changes in flows with all markets except the UK on changes in flows with the UK. In order to solve the positive correlation of trade flows between different markets we use the Brexit referendum as part of our instrumental variable. We then treat firms as units subjected to differential uncertainty shocks according to their initial patterns of sector and trade specialization. In particular, the referendum date is interacted with potential sectoral tariffs and pre‐referendum firm‐level exposure to the UK. The paper shows a close to full trade diversion for exports, mostly to other European countries, for those firms more exposed to that particular market (above 10%) and a heterogeneous response on the part of Spanish firms with low exposure (below 10%). Trade diversion for imports is weaker but the results are less robust. Given a particular share of exposure to the UK market, trade diversion appears to be more limited for big companies in comparison to small companies.
Evaluating the efficacy of OralDETECT training: Face‐to‐face versus online delivery in dental education
Authors: Ramanathan Anand , Zaini Zuraiza Mohamad , Ghani Wan Maria Nabillah , Wong Gou Rean , Zainuddin Nurul Izyan , Yang Yi Hsin , Zain Rosnah Binti 
Published: March 2024

AbstractObjectiveThis study evaluated the effectiveness of face‐to‐face (F2F) and online OralDETECT training programme in enhancing early detection skills for oral cancer.MethodsA total of 328 final‐year dental students were trained across six cohorts. Three cohorts (175 students) received F2F training from the academic years 2016/2017 to 2018/2019, and the remaining three (153 students) underwent online training during the Covid‐19 pandemic from 2019/2020 to 2021/2022. Participant scores were analysed using the Wilcoxon signed rank test, the Mann‐Whitney test, Cohen's d effect size, and multiple linear regression.ResultsBoth F2F and online training showed increases in mean scores from pre‐test to post‐test 3: from 67.66 ± 11.81 to 92.06 ± 5.27 and 75.89 ± 11.03 to 90.95 ± 5.22, respectively. Comparison between F2F and online methods revealed significant differences in mean scores with large effect sizes at the pre‐test stage (p < 0.001), while significant differences with small effect sizes were noted for post‐test 1 (p = 0.002) and post‐test 3 (p = 0.041). Regression analysis indicated that the delivery method is associated with the participants' final scores.ConclusionF2F and online versions of the OralDETECT training programme significantly enhance participants' knowledge and skills in oral cancer detection. Although F2F appeared to be more effective, the difference was not substantial enough to be considered educationally meaningful.
FGFR2 and miR‐889‐3p expression in oral cancer is associated with cervical lymph node metastasis
Authors: Mehdikhani Fariba , Atashbasteh Mostafa , Azadi Mehdi , Allameh Abdolamir 
Published: March 2024

AbstractObjectiveFibroblast growth factor receptor‐2 (FGFR2) and miR‐889‐3p expression in oral squamous cell carcinoma (OSCC) tumours were compared to normal controls. We then examined the relationship between miR‐889‐3p, FGFR2 expression and patient clinicopathological features.Materials and MethodsThe interaction of FGFR2 and miR‐889‐3p was investigated using bioinformatics. Then, OSCC tumour biopsies and normal gingiva were collected and processed for expression analysis of FGFR2‐specific mRNA and miR‐889‐3p using real‐time PCR. Immunohistochemistry evaluated the expression of the FGFR2 protein.ResultsThe protein and mRNA expression levels of FGFR2 were significantly greater in tumours when contrasted with controls. Expression of miR‐889‐3p was significantly lower in OSCC compared to normal tissues. The FGFR2 and miR‐889‐3p expressions were inversely related (−0.86 and −0.73, respectively) in both cases and controls. Changes in miR‐889‐3p and FGFR2 expression in tumour tissues were associated with lymph node metastasis (LNM), with ~0.57 and ~3.0 folds of change in positive‐LNM patients, respectively.ConclusionDecreased expression of miR‐889‐3p in OSCC tumours suggests that miR‐889‐3p functions as a tumour suppressor gene. Overexpression of FGFR2 further proves the role of miR‐889‐3p in the regulation of the FGFR2 pathway. This was further confirmed by showing differences in miR‐889‐3p expression in positive and negative LNM cases.