bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating causal relationships between extensive peripheral immune cell phenotypes and preeclampsia: A bi‐directional Mendelian randomization analysis
Authors: Liao Chung‐Chih , Ku Ju‐Chun , Lin Cheng‐Li , Li Ju‐Wan , Tsai Fuu‐Jen , Li Jung‐Miao 
Published: April 2024

AbstractProblemPreeclampsia, a multifaceted condition during pregnancy characterized by hypertension and organ dysfunction, poses significant risks to both maternal and fetal health. This study aims to investigate the bidirectional causal relationship between peripheral immune cell phenotypes and preeclampsia using a two‐sample Mendelian randomization (MR) approach.Method of studyGenetic data from two sizable cohorts were utilized: 3757 individuals from Sardinia, providing information on 731 immune traits, and 200 929 Finnish adult females, encompassing 6663 preeclampsia cases. Single‐nucleotide polymorphisms served as instrumental variables. The MR analyses employed the inverse variance‐weighted (IVW) method as the primary tool, supplemented by MR‐Egger, weighted median, and weighted mode methods to enhance reliability and address potential heterogeneity and horizontal pleiotropy.ResultsAmong the 731 immune cell phenotypes studied, 18 displayed a suggestive positive association (IVW p < .05) with heightened preeclampsia risk, while 20 exhibited a suggestive negative association linked to reduced risk. Following false discovery rate (FDR) adjustment, four immune phenotypes showed significant associations with decreased preeclampsia risk: CD27 on CD24+ CD27+ B cells (B‐cell panel) (odds ratio [OR] = 0.927, PFDR = 0.061), CD33+ HLA DR+ CD14− absolute count (OR = 0.963, PFDR = 0.061), CD80 on plasmacytoid dendritic cells (OR = 0.923, PFDR = 0.061); and CD80 on CD62L+ plasmacytoid dendritic cells (OR = 0.923, PFDR = 0.061). In the reverse‐direction MR analysis, no significant causal effects of preeclampsia on immune cell phenotypes were observed.ConclusionsThis study provides quantifiable evidence linking specific immune cell phenotypes to the risk of developing preeclampsia. This novel understanding of the immunological aspects underlying preeclampsia's pathogenesis could lead to innovative therapeutic strategies centered on immune modulation.
Efficiency of CONTRAfluran™ in reducing sevoflurane pollution from maintenance anaesthesia in minimal flow end‐tidal control mode for laparoscopic surgery
Authors: Mulier Harold , Struys Michel M. R. F , Vereecke Hugo , Rex Steffen , Teunkens An , Kalmar Alain F. 
Published: April 2024

SummaryBackgroundRecommendations exist that aim to mitigate the substantial ecological impact of anaesthesia. One option is to use anaesthetic gas capturing technology at anaesthesia workstation exhausts to harvest and recycle volatile agents. However, the efficiency of such technology is mainly unverified in vivo.MethodsThe efficiency of CONTRAfluran™ in capturing sevoflurane from an anaesthesia workstation exhaust (when set to minimal flow and end‐tidal control mode) was evaluated in 70 adult patients scheduled for general or bariatric laparoscopic surgery. The weight of the sevoflurane vaporiser and CONTRAfluran canister was measured before and after each case, to calculate total sevoflurane consumption and retention. Retention was measured after the minimal flow maintenance phase and after the high flow washout phase. The total retention efficiency was the fraction of all consumed sevoflurane captured by the CONTRAfluran canister. The primary objective was to examine the retention efficiency of CONTRAfluran in a clinical surgical setting, where all feasible strategies to minimise sevoflurane consumption and optimise the efficacy of CONTRAfluran were utilised. The secondary objective was to analyse the correlation between mass transfer and the duration of the case.ResultsMean (SD) volume of sevoflurane captured using CONTRAfluran was 4.82 (1.41) ml, representing 45% (95%CI 42–48%) of all sevoflurane administered. The highest amount of retention was found during the washout phase. Retention efficiency did not correlate with the duration of the case.ConclusionsOver half of the sevoflurane administered was not captured by the CONTRAfluran canister when minimal flow techniques were used, likely due to residual accumulation of sevoflurane in the patient after tracheal extubation or, to a lesser extent, due to ventilation system leakage. However, as every prevented emission is commendable, CONTRAfluran may be a potentially valuable tool for reducing the environmental footprint of sevoflurane‐based anaesthesia.
Is more always better? Effectiveness of constraint‐induced movement therapy in children with high‐risk or unilateral cerebral palsy (0–6 years): Systematic review and meta‐analysis
Authors: Merino‐Andrés Javier , López‐Muñoz Purificación , Carrión Rocío Palomo , Martín‐Casas Patricia , Ruiz‐Becerro Irene , Hidalgo‐Robles Álvaro 
Published: April 2024

AbstractBackgroundWhile constraint‐induced movement therapy is strongly recommended as an intervention for infants with unilateral cerebral palsy, the optimal dosage remains undefined. This systematic review aims to identify the most effective level of intensity of constraint‐induced movement therapy to enhance manual function in infants at high risk of asymmetric brain lesions or unilateral cerebral palsy diagnosis.MethodsThis systematic review with meta‐analysis encompassed a comprehensive search across four electronic databases to identify articles that met the following criteria: randomised controlled trials, children aged 0–6 with at high risk or with unilateral cerebral palsy, and treatment involving constraint‐induced movement therapy for upper limb function. Studies with similar outcomes were pooled by calculating the standardised mean difference score for each subgroup, and subgroups were stratified every 30 h of total intervention dosage (30–60, 61–90, >90 h). Risk of bias was assessed with Cochrane Collaboration's tool.ResultsSeventeen studies were included. Meta‐analyses revealed significant differences among subgroups. The 30–60 h subgroup showed a weak effect for spontaneous use of the affected upper limb during bimanual performance, grasp function, and parents' perception of how often children use their affected upper limb. Additionally, this subgroup demonstrated a moderate effect for the parents' perception of how effectively children use their affected upper limb.ConclusionsUsing a dosage ranging from 30 to 60 h when applying a constraint‐induced movement therapy protocol holds promise as the most age‐appropriate and cost‐effectiveness approach for improving upper limb functional outcomes and parent's perception.
Use of empirical medical therapies for idiopathic male infertility in Australia and New Zealand
Authors: Catford Sarah R. , Katz Darren , McLachlan Robert I. 
Published: April 2024

AbstractObjectiveIdiopathic male infertility is common, yet there is no approved treatment. This study aimed to understand practice patterns towards empirical medical therapy (EMT) for idiopathic male infertility in Australia and New Zealand (NZ).DesignClinical members of the Endocrine Society of Australia, Fertility Society of Australia & NZ, and Urological Society of Australia & NZ were invited to complete a survey. Questions included demographics, EMT practice habits, and thoughts regarding infertility case scenarios. Unadjusted group differences between specialists, those with and without additional training in male infertility, and frequency of managing it were evaluated.ResultsOverall, 147 of 2340 members participated (6.3%); majority were endocrinologists and gynaecologists. Participants were experienced; 35% had completed additional training in male infertility and 36.2% reported they frequently manage male infertility. Gynaecologists were more likely to manage male infertility and attend education courses than endocrinologists and urologists. Beliefs about the effect of EMT on sperm concentration and pregnancy did not differ between speciality types. Many respondents considered all patient scenarios suitable for EMT. Of medications, hCG and clomiphene were selected most. Two respondents indicated they would use testosterone to treat male infertility.ConclusionsThis study demonstrates common use of EMT in Australia and NZ for idiopathic male infertility. The breadth of responses reflects a lack of consensus within the current literature, highlighting the need for further research to clarify their role in the management of idiopathic male infertility.
Expanding the understanding of telomere biology disorder with reports from two families harboring variants in ZCCHC8 and TERC
Authors: Nitschke Nikolaj Juul , Jelsig Anne Marie , Lautrup Charlotte , Lundsgaard Malene , Severinsen Marianne Tang , Cowland Jack Bernard , Maroun Lisa Leth , Andersen Mette Klarskov , Grønbæk Kirsten 
Published: April 2024

AbstractTelomere biology disorder (TBD) can present within a wide spectrum of symptoms ranging from severe congenital malformations to isolated organ dysfunction in adulthood. Diagnosing TBD can be challenging given the substantial variation in symptoms and age of onset across generations. In this report, we present two families, one with a pathogenic variant in ZCCHC8 and another with a novel variant in TERC. In the literature, only one family has previously been reported with a ZCCHC8 variant and TBD symptoms. This family had multiple occurrences of pulmonary fibrosis and one case of bone marrow failure. In this paper, we present a second family with the same ZCCHC8 variant (p.Pro186Leu) and symptoms of TBD including pulmonary fibrosis, hematological disease, and elevated liver enzymes. The suspicion of TBD was confirmed with the measurement of short telomeres in the proband. In another family, we report a novel likely pathogenic variant in TERC. Our comprehensive description encompasses hematological manifestations, as well as pulmonary and hepatic fibrosis. Notably, there are no other reports which associate this variant to disease. The families expand our understanding of the clinical implications and genetic causes of TBD.
GATAD2B is required for pre‐implantation embryonic development by regulating zygotic genome activation
Authors: Lin Yuling , Yu Lina , Xu Qian , Qiu Panpan , Zhang Yang , Dong Xiaohan , Yan Guijun , Sun Haixiang , Cao Guangyi 
Published: April 2024

AbstractMajor zygotic genome activation (ZGA) occurs at the late 2‐cell stage and involves the activation of thousands of genes, supporting early embryonic development. The reasons underlying the regulation of ZGA are not clear. Acetylation modifications of histone tails promote transcriptional activation, and the maternal deletion of H4K16ac leads to failure in ZGA. GATAD2B is one of the core subunits of the nucleosome remodelling and histone deacetylation (NuRD) complex. Our research has shown that GATAD2B exhibits specific nucleus localization and high protein expression from the late 2‐cell stage to the 8‐cell stage. This intriguing phenomenon prompted us to investigate the relationship between GATAD2B and the ZGA. We discovered a distinctive pattern of GATAD2B, starting from the late 2‐cell stage with nuclear localization. GATAD2B depletion resulted in defective embryonic development, including increased DNA damage at morula, decreased blastocyst formation rate, and abnormal differentiation of ICM/TE lineages. Consistent with the delay during the cleavage stage, the transcriptome analysis of the 2‐cell embryo revealed inhibition of the cell cycle G2/M phase transition pathway. Furthermore, the GATAD2B proteomic data provided clear evidence of a certain association between GATAD2B and molecules involved in the cell cycle pathway. As hypothesized, GATAD2B‐deficient 2‐cell embryos exhibited abnormalities in ZGA during the maternal‐to‐embryonic transition, with lower expression of the major ZGA marker MERVL. Overall, our results demonstrate that GATAD2B is essential for early embryonic development, in part through facilitating ZGA.
From paralyzing to actionable futures: Facilitating farmer participation in water conservation through a multiscalar horizoning work approach
Authors: Brause Holly 
Published: April 2024

AbstractIn the Mesilla and Rincon Valleys of southern New Mexico, prolonged drought, climate change, increased competition for water, and an ongoing lawsuit with Texas over groundwater pumping create precarity in regard to long‐term water resources for agricultural production. As the sector that uses the most water in New Mexico, agricultural participation in water conservation is critical. Using ethnographic data, along with the key concepts of horizons of the future and scale, I examine barriers to addressing water‐scarce futures in the present. Ultimately, I argue that adding a multiscalar approach to the established framework of “horizoning work” can generate collaborative water conservation efforts with localized, temporally limited scopes to facilitate farmer participation in efforts to address water‐scarce futures.
Prospective validation of a seizure diary forecasting falls short
Authors: Goldenholz Daniel M. , Eccleston Celena , Moss Robert , Westover M. Brandon 
Published: April 2024

AbstractObjectiveRecently, a deep learning artificial intelligence (AI) model forecasted seizure risk using retrospective seizure diaries with higher accuracy than random forecasts. The present study sought to prospectively evaluate the same algorithm.MethodsWe recruited a prospective cohort of 46 people with epilepsy; 25 completed sufficient data entry for analysis (median = 5 months). We used the same AI method as in our prior study. Group‐level and individual‐level Brier Skill Scores (BSSs) compared random forecasts and simple moving average forecasts to the AI.ResultsThe AI had an area under the receiver operating characteristic curve of .82. At the group level, the AI outperformed random forecasting (BSS = .53). At the individual level, AI outperformed random in 28% of cases. At the group and individual level, the moving average outperformed the AI. If pre‐enrollment (nonverified) diaries (with presumed underreporting) were included, the AI significantly outperformed both comparators. Surveys showed most did not mind poor‐quality LOW‐RISK or HIGH‐RISK forecasts, yet 91% wanted access to these forecasts.SignificanceThe previously developed AI forecasting tool did not outperform a very simple moving average forecasting in this prospective cohort, suggesting that the AI model should be replaced.
Effects of lianas on forest biogeochemistry during their lives and afterlives
Authors: Dossa Gbadamassi G. O. , Li Hong‐Lin , Pan Bo , Ling Tial C. , Schaefer Douglas A. , Roeder Mareike , Njoroge Denis M. , Zuo Juan , Song Liang , Ofosu‐Bamfo Bismark , Schnitzer Stefan A. , Harrison Rhett D. , Bongers Frans , Zhang Jiao‐Lin , Cao Kun‐Fang , Powers Jennifer S. , Fan Ze‐Xin , Chen Ya‐Jun , Corlett Richard T. , Zotz Gerhard , Oleksyn Jacek , Wyka Tomasz P. , Codjia Jean Evans Israel , Cornelissen Johannes H. C. 
Published: April 2024

AbstractClimate change and other anthropogenic disturbances are increasing liana abundance and biomass in many tropical and subtropical forests. While the effects of living lianas on species diversity, ecosystem carbon, and nutrient dynamics are receiving increasing attention, the role of dead lianas in forest ecosystems has been little studied and is poorly understood. Trees and lianas coexist as the major woody components of forests worldwide, but they have very different ecological strategies, with lianas relying on trees for mechanical support. Consequently, trees and lianas have evolved highly divergent stem, leaf, and root traits. Here we show that this trait divergence is likely to persist after death, into the afterlives of these organs, leading to divergent effects on forest biogeochemistry. We introduce a conceptual framework combining horizontal, vertical, and time dimensions for the effects of liana proliferation and liana tissue decomposition on ecosystem carbon and nutrient cycling. We propose a series of empirical studies comparing traits between lianas and trees to answer questions concerning the influence of trait afterlives on the decomposability of liana and tree organs. Such studies will increase our understanding of the contribution of lianas to terrestrial biogeochemical cycling, and help predict the effects of their increasing abundance.
KF‐metaweb: A trophic metaweb of freshwater ecosystems of South Korea
Authors: Adhurya Sagar , Lee Da‐Yeong , Park Young‐Seuk 
Published: April 2024

AbstractMotivationThe metaweb is a dictionary of nodes and their potential interactions developed for a particular region, focusing on a particular type of ecosystem. Based on the local biodiversity information at different spatial and temporal scales, the regional metaweb can be easily decomposed into local webs. The generated local webs are useful for understanding spatiotemporal variations in ecological interactions in a particular region. In this study, an attempt was made to develop a trophic metaweb for freshwater ecosystems in South Korea, called the KF‐metaweb. The metaweb contains 23,074 interactions between 446 taxa collected from 730 studies. This metaweb can be used to understand the spatiotemporal variability of different local food webs and the effects of the environment on food web properties. Furthermore, this is the first metaweb developed for any Asian ecosystem that contains information about many interactions that are unavailable in any other existing database. In addition, this metaweb study enriches our global understanding of ecological interactions.Main Types of Variables ContainedThe data contained trophic interactions between resources (prey) and consumers (predators).Spatial Location and GrainThe mainland of South Korea and Jeju Island.Time Period and Grain2008–2021.Major TaxaMicroalgae (belonging to the phyla Cyanobacteria, Bygra, Cryophyta, Myozoa, Ochrophyta, Charophyta, Chlorophyta, Euglenozoa and Mycetozoa), zooplankton (belonging to the phyla Arthropoda and Rotifera), benthic macroinvertebrates (Platyhelmenthes, Annelida, Arthropoda and Mollusca) and fish.Level of MeasurementMinimum taxonomic resolution was at the genus level for fish and benthic macroinvertebrates and order level for zooplankton and microalgae.Software FormatExcel (*.xlsx).
‘GRADE, WEIL ICH MICH ALS DEUTSCHEN FÜHLE’: THE PROGRESSIVE PATRIOTISM OF DIE WELTBÜHNE
Authors: Arscott Jack 
Published: April 2024

ABSTRACTThis article investigates the under‐researched phenomenon of left‐wing patriotism through the prism of the Weimar‐era weekly journal Die Weltbühne. Drawing on my recently completed doctoral thesis on this subject, I argue that patriotism and nationalism must be understood as two separate concepts capable of being driven by contrasting political agendas. To this end, I first critically examine a handful of canonical studies of nationalism and patriotism, pointing out a pronounced tendency in scholarship both to equate the two and to undermine the basis for existence of any form of patriotism. I then trace the origins of left‐wing German patriotism back to the early nineteenth century, briefly considering two texts by Heinrich Heine, Deutschland. Ein Wintermärchen and Zur Geschichte der Religion und Philosophie in Deutschland, before turning to my case study. Choosing a small but representative number of texts from the journal's expansive corpus, I set out the three pillars on which my analysis depends: regionalism, internationalism and socialism. In so doing, I demonstrate the need to revise our understanding both of the position of Die Weltbühne within Weimar journalism and of the potential of patriotism to serve progressive political ends.
Association of sense of coherence and periodontal disease severity, in two cross‐sectional studies
Authors: Wahlin Åsa , Lindmark Ulrika , Norderyd Ola 
Published: April 2024

AbstractObjectivesTo investigate the association between the individuals' level of sense of coherence (SOC) and periodontal disease severity.MethodsThe study populations originated from two stratified cross‐sectional random samples of residents in a medium‐sized Swedish city in 2003 and 2013, respectively. The final samples constituted 491 individuals in 2003 and 538 individuals in 2013. The samples were classified into three groups according to the severity of periodontitis (no/minor, moderate and severe). The 13‐item Swedish version of Antonovsky's “Orientation to life” questionnaire, measuring the individual's SOC, was filled out. Descriptive statistics were performed as well as multinomial logistic regression analysis. Dependent variable was the severity of periodontal disease and independent variables, age in years, presently smoking and education at university level.ResultsIn the multinomial regression analysis, smoking, age, and total SOC score were significantly associated with severe periodontitis at both examinations. The strongest predictor of severe periodontal disease was smoking. The total SOC score did not differ between the examinations, but there was a statistically significant difference in two of the SOC dimensions, manageability (lower), and comprehensibility (higher), over time.ConclusionsIndividuals with severe periodontitis had significantly lower SOC compared to subjects periodontally having no/minor periodontal disease. Smoking was the strongest overall predictor of having severe periodontitis.
Mixed processing improved the theaflavin, theanine and aroma components of Congou black tea
Authors: Zuo Haoming , Lv Zhidong , Guo Shuning , Zhou Yuebing , Shen Chengwen 
Published: April 2024

SummaryCongou black tea is mainly processed from single variety leaves, with obvious variety characteristics. This study investigated the effects of mixed processing withered leaves varieties on sensory quality, the volatile and non‐volatile compounds of seven Congou black tea samples. Sensory quality evaluation revealed that the Congou black tea with three leaves varieties were fresher, more floral and had coordinate taste. The total quality score was in the order: MPH > H > M&H > M > M&P > H&P > P. However, samples MPH and M&H have a higher content of theaflavins and amino acids, especially theanine. Furthermore, 130 volatile substances were identified in seven black teas by using HS‐SPME/GC–MS. M&H and MPH have more aroma types and total amount than that of M, P and H. The mixed processing of withered leaves may fully use the catalysis of endogenous enzymes to increase the 19 kinds of black tea key aromas including Benzyl alcohol, trans‐2‐hexenyl hexanoate, Hexyl hexanoate and Methyl jasmonate. Thus, blended processing can enhance the taste, aroma and LC quality of black tea.