bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immunogenically optimized peptides derived from natural mutants of HIV CTL epitopes and peptide combinatorial libraries
Authors: Blondelle Sylvie E. , Moya‐Castro Rosa , Osawa Keiko , Schroder Kim , Wilson Darcy B. 
Published: May 2008

AbstractTwo strategies were aimed at identifying immunogenically optimized peptides for the potential use in the formulation of an effective prophylactic or therapeutic HIV‐1 vaccine. Three CTL epitopes were investigated: Gag p2419‐27 TV9, Gag p1777‐85 SL9, and RT309‐317 IV9. The first strategy derives from the hypothesis that a number of rare mutant CTL epitopes of HIV‐1 may be more immunogenic than the common ones. As such, these rare mutant sequences might be highly effective in generating cross reactive anti‐HIV‐1 CTL responses against a range of mutant sequences. As anticipated, several rare mutant peptide sequences were identified that generated strong CTL responses against both the consensus sequences and several naturally occurring mutants in human PBL cultures primed ex vivo and in HLA‐A2 transgenic mice immunized in vivo. Finally, to reach beyond the sequence diversity of the “natural” library of mutated sequences, a synthetic combinatorial peptide library was screened with a TV9 specific T‐cell line; this resulted in the identification of an immunogenically optimized mimic peptide sequence that provoked highly effective CTL immune responses against TV9 and mutants. Sequence homologies between the natural mutants and synthetic mimic may provide insight into key contact positions in the MHC/TCR/peptide complex. © 2008 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 90: 683–694, 2008.This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com
Theoretical and Experimental Evaluation of a CYP106A2 Low Homology Model and Production of Mutants with Changed Activity and Selectivity of Hydroxylation
Authors: Lisurek Michael , Simgen Birgit , Antes Iris , Bernhardt Rita 
Published: May 2008

AbstractSteroids are important pharmaceutically active compounds. In contrast to the liver drug‐metabolising cytochrome P450s, which metabolise a variety of substrates, steroid hydroxylases generally display a rather narrow substrate specificity. It is therefore a challenging goal to change their regio‐ and stereoselectivity. CYP106A2 is one of only a few bacterial steroid hydroxylases and hydroxylates 3‐oxo‐Δ4‐steroids mainly in 15β‐position. In order to gain insights into the structure and function of this enzyme, whose crystal structure is unknown, a homology model has been created. The substrate progesterone was then docked into the active site to predict which residues might affect substrate binding. The model was substantiated by using a combination of theoretical and experimental investigations. First, numerous computational structure evaluation tools assessed the plausibility of its protein geometry and its quality. Second, the model explains many key properties of common cytochrome P450s. Third, two sets of mutants have been heterologously expressed, and the influence of the mutations on the catalytic activity towards deoxycorticosterone and progesterone has been studied experimentally: the first set comprises six mutations located in the structurally variable regions of this enzyme that are very difficult to predict by cytochrome P450 modelling (K27R, I86T, E90V, I71T, D185G and I215T). For these positions, no participation in the active‐site formation was predicted, or could be experimentally demonstrated. The second set comprises five mutants in substrate recognition site 6 (S394I, A395L, T396R, G397P and Q398S). For these residues, participation in active‐site formation and an influence on substrate binding was predicted by docking. These mutants are based on an alignment with human CYP11B1, and in fact most of these mutants altered the active‐site structure and the hydroxylation activity of CYP106A2 dramatically.
Rational Design of Highly Active and Selective Ligands for the α5β1 Integrin Receptor
Authors: Heckmann Dominik , Meyer Axel , Laufer Burkhardt , Zahn Grit , Stragies Roland , Kessler Horst 
Published: May 2008

AbstractThe inhibition of integrin function is a major challenge in medicinal chemistry. Potent ligands are currently in different stages of clinical trials for the antiangiogenic therapy of cancer and age‐related macula degeneration (AMD). The subtype α5β1 has recently been drawn into the focus of research because of its genuine role in angiogenesis. In our previous work we could demonstrate that the lack of structural information about the receptor could be overcome by a homology model based on the X‐ray structure of the αvβ3 integrin subtype and the sequence similarities between both receptors. In this work, we describe the rational design and synthesis of high affinity α5β1 binders, and the optimisation of selectivity against αvβ3 by means of extensive SAR studies and docking experiments. A first series of compounds based on the tyrosine scaffold resulted in affinities in the low and even subnanomolar range and selectivities of 400‐fold against αvβ3. The insights about the structure–activity relationship gained from tyrosine‐based ligands could be successfully transferred to ligands that bear an aza‐glycine scaffold to yield α5β1 ligands with affinities of ∼1 nm and selectivities that exceed 104‐fold. The ligands have already been successfully employed as selective α5β1 ligands in biological research and might serve as lead structures for antiangiogenic cancer therapy.
Synthesis, Fluorescence, and Two‐Photon Absorption of Bidentate Phosphane Oxide Derivatives: Complexation with Pb2+ and Cd2+ Cations
Authors: Ha‐Thi Minh‐Huong , Penhoat Maël , Drouin Delphine , Blanchard‐Desce Mireille , Michelet Véronique , Leray Isabelle 
Published: May 2008

AbstractA series of fluorescent phosphane oxide derivatives based on diphenylphosphanoethane (DPPE) and diphenylphosphanomethane (DPPM) skeletons has been prepared by means of Grignard reactions and Sonogashira cross‐couplings. The photophysical properties and the linear and nonlinear spectra of these compounds have been investigated. An edge‐to‐face conformation resulting in the formation of an excimer was confirmed by fluorescence lifetime measurements of these multichromophoric derivatives. Upon complexation with heavy metal ions such as Pb2+ and Cd2+, a red shift of the one‐ and two‐photon excitation spectra was observed in the absorption and emission spectra. Furthermore, enhancement of the electron‐withdrawing character of the phosphane oxide resulted in a significant enhancement of the two‐photon absorption cross‐section, leading to the first biphotonic Cd2+ sensors combining high affinity for Cd2+, large two‐photon absorption cross‐sections, and significant enhancement of the two‐photon excited fluorescence in the presence of the cation. Such derivatives are highly promising for incorporation into devices for the detection of heavy metal ions in water and effluents.
Fluorescent, Synthetic Amphiphilic Heptapeptide Anion Transporters: Evidence for Self‐Assembly and Membrane Localization in Liposomes
Authors: You Lei , Gokel George W. 
Published: May 2008

AbstractSynthetic anion transporters (SATs) of the general type (n‐C18H37)2N‐COCH2OCH2CO‐(Gly)3‐Pro‐(Gly)3‐O‐n‐C7H15, 1, are amphiphilic peptides that form anion‐conducting pores in bilayer membranes. To better understand membrane insertion, assembly and aggregation dynamics, and membrane penetration, four novel fluorescent structures were prepared for use in both aqueous buffer and phospholipid bilayers. The fluorescent residues pyrene, indole, dansyl, and NBD were incorporated into 1 to give 2, 3, 4, and 5, respectively. Assembly of peptide amphiphiles in buffer was confirmed by monitoring changes in the pyrene monomer/excimer peaks observed for 2. Solvent‐dependent fluorescence changes that were observed for indole (3) and dansyl (4) side‐chained SATs in bilayers showed that these residues experienced an environment between ε=9 (CH2Cl2) and ε=24 (EtOH) in polarity. Fluorescence resonance energy transfer (FRET) between 2 and 3 demonstrated aggregation of SAT monomers within the bilayer. This self‐assembly led to pore formation, which was detected as Cl− release from the liposomes. The results of acrylamide quenching of fluorescent SATs supported membrane insertion. Studies with NBD‐labeled SAT 5 showed that peptide partition into the bilayer is relatively slow. Dithionite quenching of NBD‐SATs suggests that the amphiphilic peptides are primarily in the bilayer's outer leaflet. Images obtained by using a fluorescence microscope revealed membrane localization of a fluorescent SAT. Taken together, this study helps define the insertion, membrane localization, and aggregation behavior of this family of synthetic anion transporters in liposomal bilayers.
Aggregation Behavior and Dynamics of Synthetic Amphiphiles That Self‐Assemble to Anion Transporters
Authors: Elliott Elizabeth K. , Daschbach Megan M. , Gokel George W. 
Published: May 2008

AbstractThe amphiphilic heptapeptides—referred to as synthetic anion transporters (SATs)—mediate chloride transport in planar lipid bilayer membranes, synthetic liposomes, and mammalian cells. The SATs described have the general formula R12NCOCH2OCH2CO‐(Gly)3‐Pro‐(Gly)3‐OR2. Substitution at R1 and R2 with various aliphatic or aromatic groups alters the ability of SATs to transport chloride through a phospholipid bilayer membrane. Despite extensive structure‐activity relationship studies concerning Cl−‐mediated transport by SATs, relatively little was known about the mechanism of insertion and pore‐formation in the membrane. In the current study, the mechanistic behavior of SATs was investigated in aqueous solution and at the air–water interface. In the latter case, Langmuir trough studies and Brewster angle microscopy (BAM) revealed the extent of monolayer stability and organization for SATs. Dynamic light scattering and transmission electron microscopy (TEM) confirmed these results and defined the aggregation behavior of SATs in solution. SAT derivatives that showed low chloride transport activity organized into stable monolayers at the air–water interface, while more active SATs formed less stable monolayers. The relationship between intermolecular organization of SATs and pore‐formation in the membrane is discussed along with its implications for chloride transport.
ChemInform Abstract: Novel Trigonal ZrWMoO8 Structure and Its Transformations.
Authors: Deng Xuebin , Tao Juzhou , Yang Xiaojing , Ma Hui , Richardson James W. Jr. , Zhao Xinhua 
Published: May 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Thermodynamic Study of LiF—BeF2—ZrF4—UF4 System.
Authors: Benes O. , Konings R. J. M. 
Published: May 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Electrochemical Performances of Amorphous Carbon‐Coated Sn—Sb Particles as Anode Material for Lithium‐Ion Batteries.
Authors: Wang Zhong , Tian Wenhuai , Liu Xiaohe , Yang Rong , Li Xingguo 
Published: May 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A New Rare‐Earth Metal(III) Fluoride Oxoselenate(IV): YF[SeO3].
Authors: Lipp Christian , Schleid Thomas 
Published: May 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Lanthanumiodideethanide o‐La5I9(C2) — The Orthorhombic High Temperature Modification.
Authors: Mattausch Hansjuergen , Hoch Constantin , Simon Arndt 
Published: May 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Rapid Solid‐State Synthesis of Binary Group 15 Chalcogenides Using Microwave Irradiation.
Authors: Mastrovito Christine , Lekse Jonathan W. , Aitken Jennifer A. 
Published: May 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Characterization of Carbon‐ and Nitrogen‐Centered (Z) Trigonal Prismatic Tungsten Clusters of the Formula Type A[W6ZCl18].
Authors: Weisser Martina , Burgert Ralf , Schnoeckel Hansgeorg , Meyer H.‐Juergen 
Published: May 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Highly Site‐ and Enantioselective Cu‐Catalyzed Allylic Alkylation Reactions with Easily Accessible Vinylaluminum Reagents.
Authors: Lee Yunmi , Akiyama Katsuhiro , Gillingham Dennis G. , Brown M. Kevin , Hoveyda Amir H. 
Published: May 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Palladium‐Catalyzed Domino‐Wacker‐Carbonylation Reaction for the Enantioselective Synthesis of Chromans and Benzodioxins.
Authors: Tietze Lutz F. , Zinngrebe Julia , Spiegl Dirk A. , Stecker Florian 
Published: May 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Noncovalently Supported Heterogeneous Chiral Amine Catalysts for Asymmetric Direct Aldol and Michael Addition Reactions.
Authors: Luo Sanzhong , Li Jiuyuan , Zhang Long , Xu Hui , Chen Jin‐Pei 
Published: May 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Iridium‐Catalyzed Consecutive and Enantioselective [2 + 2 + 2] Cycloaddition of Tetraynes and Hexaynes for the Construction of an Axially Chiral Biaryl System.
Authors: Shibata Takanori , Yoshida Shiho , Arai Yoshikazu , Otsuka Maiko , Endo Kohei 
Published: May 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: An Expedient Synthesis of β‐Phenyl‐Substituted Baylis—Hillman and Aza‐Baylis—Hillman Adducts
Authors: Kim Seong Jin , Lee Hyun Seung , Kim Jeong Mi , Kim Jae Nyoung 
Published: May 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Lanthanide Formamidinates as Improved Catalysts for the Tishchenko Reaction.
Authors: Zuyls Agustino , Roesky Peter W. , Deacon Glen B. , Konstas Kristina , Junk Peter C. 
Published: May 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Ni‐Catalyzed Mild Arylation of α‐Halocarbonyl Compounds with Arylboronic Acids.
Authors: Liu Chao , He Chuan , Shi Wei , Chen Mao , Lei Aiwen 
Published: May 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Steric Tuning of Silylacetylenes and Chiral Phosphine Ligands for Rhodium‐Catalyzed Asymmetric Conjugate Alkynylation of Enones.
Authors: Nishimura Takahiro , Guo Xun‐Xiang , Uchiyama Nanase , Katoh Taisuke , Hayashi Tamio 
Published: May 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Ketone Super Silyl Enol Ethers in Sequential Reactions: Diastereoselective Generation of Tertiary Carbinols in One‐Pot.
Authors: Boxer Matthew B. , Akakura Matsujiro , Yamamoto Hisashi 
Published: May 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Boron Trihalide Mediated Substitution of Hydroxyl Groups with Alkenyl, Alkynyl, and Allyl Moieties.
Authors: Kabalka George , Borella Scott , Yao Min‐Liang 
Published: May 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Preparation of Optically Active 1,2‐Diol Monotosylates by Enzymatic Hydrolysis.
Authors: Shimada Yasutaka , Sato Hiroshi , Minowa Shinji , Matsumoto Kazutsugu 
Published: May 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Oxazaborolidinone‐Promoted Vinylogous Mukaiyama Aldol Reactions.
Authors: Simsek Serkan , Horzella Melanie , Kalesse Markus 
Published: May 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Novel Synthetic Approach Towards N‐Phenylsuccinimides from γ‐Lactam‐2‐carboxylic Acid Derivatives by Reaction with CAN—NaBrO3.
Authors: Barman Gopa , Roy Mahuya , Ray Jayanta. K. 
Published: May 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Expeditious and Practical Synthesis of Various Substituted Taurines from Amino Alcohols.
Authors: Zhang Wei , Wang Boyuan , Chen Ning , Du Da‐Ming , Xu Jiaxi 
Published: May 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: An Efficient Synthesis Route to Novel 3‐Alkyl‐ and 3‐Aryl‐4‐iodophenols
Authors: Hermann Gesine J. , Annis Michael C. , Edwards Peter D. , Corrales Marta , Diaz Lucia , Goodnow Robert A. 
Published: May 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Indium‐Mediated vic‐Diallylation/Propargylation of Phenacyl Bromides: A Facile Synthesis of 4‐Arylocta‐1,7‐dien‐4‐ol Derivatives.
Authors: Yadav J. S. , Reddy B. V. Subba , Biswas Swapan Kumar , Sengupta Sandip , Vishnumurthy P. 
Published: May 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Facile Reduction of Malonate Derivatives Using NaBH4/Br2: An Efficient Route to 1,3‐Diols.
Authors: Tudge Matthew , Mashima Hiroko , Savarin Cecile , Humphrey Guy , Davies Ian 
Published: May 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Catalytic Asymmetric Alkylation of Aldehydes with Grignard Reagents.
Authors: Muramatsu Yusuke , Harada Toshiro 
Published: May 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.