bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the CD3/CD56/TNF-α/Caspase3 pathway in pyrethroid-induced immune dysregulation: curcumin-loaded chitosan nanoparticle intervention
Authors: Alsubaie Nawal , Abd-Elhakim Yasmina M. , Mohamed Amany Abdel-Rahman , Khamis Tarek , Metwally Mohamed M. M. , Helmi Nawal , Alnajeebi Afnan M. , Alotaibi Badriyah S. , Albaqami Amirah , Mawkili Wedad , Samak Mai A. , Eissa Samar A. 
Published: February 2025

IntroductionConflict reports exist on the impact of pyrethroid insecticides on immune function and the probable underlying mechanisms.MethodsThis study evaluated the effect of an extensively used pyrethroid insecticide, fenpropathrin (FTN) (15 mg/kg b.wt), on the innate and humoral immune components, blood cells, splenic oxidative status, and mRNA expression of CD3, CD20, CD56, CD8, CD4, IL-6, TNF-α, and Caspase3 in a 60-day trial in rats. Besides, the possible defensive effect of curcumin-loaded chitosan nanoparticle (CML-CNP) (50 mg/kg b.wt) was evaluated.ResultsFTN exposure resulted in hypochromic normocytic anemia, thrombocytosis, leukocytosis, and lymphopenia. Besides, a significant reduction in IgG, not IgM, but increased C3 serum levels was evident in the FTN-exposed rats. Moreover, their splenic tissues displayed a substantial increase in the ROS, MDA, IL-6, and IL-1β content, altered splenic histology, and reduced GPX, GSH, and GSH/GSSG. Furthermore, a substantial upregulation of mRNA expression of splenic CD20, CD56, CD8, CD4, CD3, IL-6, and TNF-α, but downregulation of CD8 was detected in FTN-exposed rats. FTN exposure significantly upregulated splenic Caspase-3 and increased its immunohistochemical expression, along with elevated TNF-α immunoexpression. However, the alterations in immune function, splenic antioxidant status, blood cell populations, and immune-related gene expression were notably restored in the FTN + CML-CNP-treated group.ConclusionThe findings of this study highlighted the immunosuppressive effects of FTN and suggested the involvement of many CD cell markers as a potential underlying mechanism. Additionally, the results demonstrated the effectiveness of CML-CNP in mitigating pollutant-induced immune disorders.
Effects of group sports activities on physical activity and social interaction abilities of children with autism spectrum disorders
Authors: Xing Yu , Huang Shuaibin , Zhao Yatong , Wu Xueping 
Published: February 2025

IntroductionGroup sports activities have been demonstrated to have an impact on the physical activity and social interaction abilities of children with autism spectrum disorder (ASD).MethodsThus, this work, taking different types of group sports as the primary variable, explored the impact of 12-week group sports activities on the physical activity and social interaction abilities of children with ASD. A quasi-experimental design was used to divide 21 children with ASD into Experimental group (N = 11) and Control group 1 (N = 10), while healthy children of the same age were selected as Control group 2 (N = 12). The experimental group performed group sports activities for 60 min/time, 4 times/week, for a total of 12 weeks, while the control group maintained the traditional sports activities of Peizhi School. Physical activity was monitored using a three-axis accelerometer (Model: ActiGraph GT3X+), and social interaction ability was measured using the playground observation of peer engagement (POPE) observation scale to evaluate the social interaction states of children in the experimental group after the physical activities.Results and discussionAfter the intervention, the sitting time of children in the experimental group was significantly reduced (t = −12.735, p &lt; 0.001, Cohen d = 2.75), and the time of moderate and high-intensity physical activity was significantly increased (t = −8.79, p &lt; 0.001, Cohen d = 1.82). In social interaction ability, the duration of loneliness was significantly reduced (t = −2.567, p &lt; 0.017, Cohen d = 0.57), and the duration of joint participation (t = −3.009, p &lt; 0.007, Cohen d = 0.02) and the regular game (t = −2.511, p &lt; 0.026, Cohen d = 0.46) were significantly increased, respectively. 4 weeks after the intervention, the sedentary behavior and loneliness of the experimental group both continued to decrease. Group physical activities can improve the physical activity levels and social interaction skills of children with ASD and have a good effect on the maintenance.
A narrative literature review to inform the development of a health threats preparedness framework in Ireland
Authors: Marron Louise , Gilroy James , Williams Michelle , Parlour Randal , Boland Máirín 
Published: February 2025

IntroductionPublic health emergency preparedness requires capacities and capabilities to respond to a diverse range of health threats. A key objective of Ireland’s recent Health Protection Strategy is to enable preparedness, prevention, early detection and optimal response to health threats from all-hazards. We aimed to identify priority areas for inclusion in an evidence-based health threats preparedness framework, using lessons from the COVID-19 pandemic, to inform a national health threats strategy and a strengthened emerging health threats function for Ireland.MethodsWe conducted a narrative literature review to inform the health threats preparedness framework development. We carried out literature searches in two phases, from 2017 to 2022, followed by an updated search covering 2022–2024, to ensure all relevant, recent literature was captured. We used a data extraction tool to collate priority areas reported.ResultsOverarching priorities for health threats preparedness are rapid decision-making, an outcomes-based, and ethical approach. Health threats preparedness should include a risk-based, all-hazards, One Health approach, aligned with legislation. Multisectoral partnerships, collaboration and communication nationally and internationally are key, alongside clear governance structures and monitoring and evaluation. Adequate resources are required to operationalize effective and sustainable preparedness. Public health leadership must be to the fore.ConclusionAn effective health threats preparedness approach is legislatively mandated for European Member States. This evidence review highlights priority areas for a comprehensive health threats preparedness framework. This framework supports the development of a strengthened emerging health threats function in Ireland and may inform other Member States’ preparedness.
Impact of Saccharomyces cerevisiae on the intestinal microbiota of dogs with antibiotic-induced dysbiosis
Authors: Arghavani Sara , Chorfi Younes , Segura Mariela , Lesaux Achraf Adib , Costa Marcio C. 
Published: February 2025

IntroductionThe gut microbiota plays an important role in the health of dogs, but treatment with antibiotics causes marked dysbiosis. The objectives of this study were to evaluate the impact of yeast probiotic Saccharomyces cerevisiae supplementation on the fecal microbiota of dogs and its potential to prevent dysbiosis induced by antibiotics.MethodsTwenty healthy adult dogs were divided into a control and a yeast probiotic group receiving 1g/kg of S. cerevisiae (Actisaf®, Phileo by Lesaffre, Marcq-en-Barœul, France) daily from D0 to D31. Both groups were given oral metronidazole from D11 to D17. Fecal swabs were collected on D0, 3, 11, 17, 20, 24, and 31 for microbiota analysis and blood on D0 and D24 for measurements of cytokines and cortisol.Results and discussionAt D0, two distinct microbiota profiles comprised of dogs from both groups, control and probiotic, were identified. One profile had higher abundances of species related to stress and inflammation, and the other comprised species associated with good intestinal health. After three days of supplementation with yeast probiotic S. cerevisiae, all five dogs from the probiotic group having a stress-related microbiota (membership) shifted to a healthy microbiota. Metronidazole markedly changed the microbiota of both groups (p &lt;0.001). Still, treated dogs had significantly different microbiota on D17 (end of antibiotics treatment). The dysbiosis was resolved in both groups by D24. TNF-α remarkably decreased from D0 to D24 (p = 0.002) in the probiotic group, which also had lower levels than controls on D24 (p = 0.040). There were no significant differences in the other measured cytokines. It was concluded that the use of yeast probiotic S. cerevisiae positively shifted the microbiota composition of healthy adult dogs carrying an abnormal microbial profile and that it has the potential to attenuate the dysbiosis caused by oral metronidazole.
LeafLaminaMap: Exploring Leaf Color Patterns Using RGB Color Indices
Authors: Bodor-Pesti Péter , Nguyen Lien Le Phuong , Nguyen Thanh Ba , Dam Mai Sao , Taranyi Dóra , Baranyai László 
Published: February 2025

The color of the plant leaves is a major concern in many areas of agriculture. Pigmentation and its pattern provide the possibility to distinguish genotypes and a basis for annual crop management practices. For example, the nutrient and water status of plants is reflected in the chlorophyll content of leaves that are strongly linked to the lamina coloration. Pests and diseases (virus or bacterial infections) also cause symptoms on the foliage. These symptoms induced by biotic and abiotic stressors often have a specific pattern, which allows for their prediction based on remote sensing. In this report, an RGB (red, green and blue) image processing system is presented to determine leaf lamina color variability based on RGB-based color indices. LeafLaminaMap was developed in Scilab with the Image Processing and Computer Vision toolbox, and the code is available freely at GitHub. The software uses RGB images to visualize 29 color indices and the R, G and B values on the lamina, as well as to calculate the statistical parameters. In this case study, symptomatic (senescence, fungal infection, etc.) and healthy grapevine (Vitis vinifera L.) leaves were collected, digitalized and analyzed with the LeafLaminaMap software according to the mean, standard deviation, contrast, energy and entropy of each channel (R, G and B) and color index. As an output for each original image in the sample set, the program generates 32 images, where each pixel is constructed using index values calculated from the RGB values of the corresponding pixel in the original image. These generated images can subsequently be used to help the end-user identify locally occurring symptoms that may not be visible in the original RGB image. The statistical evaluation of the samples showed significant differences in the color pattern between the healthy and symptomatic samples. According to the F value of the ANOVA analysis, energy and entropy had the largest difference between the healthy and symptomatic samples. Linear discriminant analysis (LDA) and support vector machine (SVM) analysis provided a perfect recognition in calibration and confirmed that energy and entropy have the strongest discriminative power between the healthy and symptomatic samples. The case study showed that the LeafLaminaMap software is an effective environment for the leaf lamina color pattern analysis; moreover, the results underline that energy and entropy are valuable features and could be more effective than the mean and standard deviation of the color properties.
Low-voltage and high-speed ferroelectric liquid crystal devices for high-resolution driving in electronic holographic displays
Authors: Kobayashi Hiroki , Tochigi Hiroto , Nakatani Masakazu , Aoshima Ken-ichi , Kawana Mayumi , Yamaguchi Yuta , Machida Kenji , Funabashi Nobuhiko , Fujikake Hideo 
Published: February 2025

Abstract
We present a method to enhance the layered structure of surface-stabilized ferroelectric liquid crystals (SSFLCs) for low-voltage, high-speed operation in electronic holographic displays. By applying a combination of heating, slow cooling, and square-wave low-voltage (<1 V), we reduced the switching voltage and achieved sub-1 ms switching times, fulfilling the 360–720 Hz requirements for spatial light modulators (SLMs) in electronic holographic displays. Switching angles and switching times to voltage application, including high voltages, were clarified for such devices. The proposed method also suppressed zigzag defects, improving uniformity and light efficiency. This work advances high-resolution SSFLC-based SLMs for next-generation 3D holographic displays.
Atypical symptoms in the diagnosis of rectus sheath hematoma after laparoscopic cholecystectomy.
Authors: Berlanga Jiménez L , Gallego Vela A , Chivite Moreno A 
Published: February 2025

Resumen

El hematoma de la vaina de los músculos rectos (HVR), es una acumulación de sangre dentro de la capa de tejido que rodea los músculos rectos del abdomen. Es una causa poco común de dolor abdominal, constituyendo aproximadamente, el 2 % del total. Se relaciona frecuentemente con el uso de anticoagulación, con el traumatismo abdominal de alto impacto y actualmente, con las heridas ocasionadas por los trócares de laparoscopia. Su curso suele ser autolimitado y con síntomas que pueden hacer que pase desapercibido, pero puede llegar a ser mortal tras un shock hipovolémico.

Con el fin de ayudar en el diagnóstico de futuros casos, exponemos el nuestro en particular.
Fast growing infraclavicular tumor. Nodular fasciitis. Is your diagnosis usually suspected?
Authors: Rodríguez Sanz MB , González de Godos A , Estébanez Peláez G , Nieto Romero de Ávila GM , Bayo Juanas P , Rodríguez Jiménez J 
Published: February 2025

Resumen

La fascitis nodular es una neoplasia benigna de etiología desconocida en la mayoría de los casos, que se caracteriza por una proliferación miofibroblástica de la fascia muscular en los tejidos blandos, aunque puede afectar a la dermis y tejido celular subcutáneo. Es de rápido crecimiento y a menudo se confunden con procesos neoplásicos malignos. Afecta con más frecuencia a adultos jóvenes. Presentamos un caso clínico de una mujer de 74 años con antecedentes de leucemia linfoide crónica de células B con trasplante alogénico que consultó por tumoración en pared torácica, en tercio medio infraclavicular derecha de consistencia dura y rápido crecimiento, tras la realización de ecografía con informe de adenopatía patológica se decidió exéresis quirúrgica para diagnóstico anátomo patológico con resultado de fascitis nodular.
Estudio y medición experimental del coeficiente de arrastre del casco de un dron submarino por medio de un túnel de viento
Authors: Rivera López Jesús Eduardo , Arciniega Martínez José Luis , Gutiérrez Paredes Guadalupe Juliana , Rodríguez Hibert César Francisco , Martínez Cabrera Cristian Ariel , Juárez Navarro Carlos Alfonso 
Published: February 2025

El presente trabajo tiene como objetivo realizar el estudio, diseño y caracterización del casco de un dron submarino por medio de la medición experimental en un túnel de viento. Para ello, se realizó el diseño de concepto, el cual se construyó por medio de la manufactura aditiva. Las corridas experimentales se realizaron para dos tipos de superficies, plana y cilíndrica en la cabeza del casco del dron. Utilizando el se determinó las velocidades de la prueba en airede 8, 10, 12, 14 y 16 m/s, de las corridas experimentales se midió la fuerza de arrastre ; del ajuste de se estimó que el error de sesgo es menor al 6 %, por lo que se puede decir que el error en las mediciones es aceptable y se puede realizar el escalamiento de los resultados. Los resultados del coeficiente de arrastre mostraron la reducción por crecimiento de capa límite y de la comparación de las geometrías plana y cilíndrica en la cabeza del casco del dron mostraron que el de la superficie cilíndrica es 33.14 y 10.71 % más grande en comparación del de la superficie plana. Para validar de una mejor manera los resultados obtenidos, se compararon con otros diseños de geometrías de casco de drones submarinos, mostrando que las geometrías curvilíneas tienen un menor , aproximadamente de 63.33 %, por lo cual este diseño no presenta el mejor resultado en arrastre en comparación con estas superficies. En la comparación con drones que no tienen casco y son geometrías de sección rectangular frontal, se tiene un 97.48 % menor arrastre, por lo cual, se puede indicar que este diseño tiene un mejor rendimiento en comparación con estas geometrías. Finalmente, se puede concluir que la geometría propuesta en este estudio tiene la longitud necesaria para disminuir el arrastre por crecimiento de capa límite y en la cabeza se debe diseñar con una superficie plana para tener un rendimiento mejorado al de los drones que no tienen casco.
Solar Modulation of Low-energy Cosmic-Ray Nitrogen and Its Comparison with Oxygen
Authors: Li Yun , Zhang Xiaoping , Fu Shuai , Shen Zhenning , Xu Yi , Lu Haoyu , Cao Jinbin , Zhu Tianle 
Published: February 2025

Abstract
The heliospheric environment is very complex and filled with diverse high-energy particles from various origins, and among these particles, cosmic rays (CRs), including anomalous and Galactic components (ACRs and GCRs), are unique as they originate from beyond the solar system. Due to their stable and long-lasting presence in the heliosphere, the study of CRs is crucial for protecting humanity and other lifeforms against the hazards of high-energy radiation. In this work, we aim to study the prolonged changes in CR nitrogen, a fundamental element that constitutes amino acids, using the measurements from the Advanced Composition Explorer (ACE) spacecraft. The comparison of solar modulation on CR nitrogen and oxygen is also made using the yearly averaged ACE observations. The ACR nitrogen has a more even spectrum than ACR oxygen while the spectrum of GCR nitrogen is more abrupt than GCR oxygen. Further model results indicate that GCR nitrogen and oxygen undergo comparable modulation processes within the heliosphere and the slight difference between the observed power-law indices of nitrogen and oxygen spectrum is due to the distinct local interstellar spectrum of the two species. Besides, an analysis is made to explain the observed more flattened ACR spectrum of nitrogen than oxygen caused by the slightly different charge-to-mass ratio Z/A.
First Detection of Radio Emission from the Intermediate-mass Black Hole in POX 52: Deep Multiband Observations with ATCA and VLA
Authors: Yuan Qi , Guo Hengxiao , Gu Minfeng , Stevens Jamie , Edwards Philip G. , Chen Yongjun , Zuo Wenwen , Sun Jingbo , Yang Jun , Lira Paulina , An Tao , Su Renzhi , Liu Yuanqi , Wang Yijun , Chang Ning , Jiang Pengfei , Zhang Ming 
Published: February 2025

Abstract
We present the first multiband centimeter detection of POX 52, a nearby dwarf galaxy believed to harbor a robust intermediate-mass black hole. We conducted the deep observations using the Australia Telescope Compact Array (ATCA), spanning frequencies from 4.5 to 10 GHz, as well as the sensitive observations from the Karl G. Jansky Very Large Array (VLA) operating in its most extended A configuration at S band (2–4 GHz) and C band (4–8 GHz). In the ATCA observations, the source shows a compact morphology, with only one direction marginally resolved. The higher resolution of the VLA allowed us to slightly resolve the source, fitting it well with a two-dimensional Gaussian model. The detected radio emission confirms the presence of active galactic nucleus (AGN) activity, indicating either a low-power jet or AGN-driven winds/outflows. Our dual-epoch observations with ATCA and VLA, together with previous nondetection flux density upper limits, reveal radio emission variability spanning two decades. In addition, we find that POX 52 aligns well with the low-mass extension of the fundamental plane for high-accretion, radio-quiet massive AGNs.
A Population Analysis of 20 Exoplanets Observed from Optical to Near-infrared Wavelengths with the Hubble Space Telescope: Evidence for Widespread Stellar Contamination
Authors: Saba Arianna , Thompson Alexandra , Yip Kai Hou , Ma Sushuang , Tsiaras Angelos , Al-Refaie Ahmed Faris , Tinetti Giovanna 
Published: February 2025

Abstract
We present a population study of 20 exoplanets, ranging from Neptune-like to inflated hot-Jupiter planets, observed during transit with the Space Telescope Imaging Spectrograph (STIS) and Wide Field Camera 3 (WFC3) instruments on board the Hubble Space Telescope (HST). To obtain spectral information from the near-ultraviolet to the near-infrared, we reanalyzed 16 WFC3 and over 50 STIS archival data sets with our dedicated HST pipeline. We also include 24 WFC3 data sets previously reduced with the same software. Across our target sample, we observe significant divergence among multiple observations conducted with the same STIS grating at various epochs, while we do not detect variations in the WFC3 data sets. These results are suggestive of stellar contamination, which we have investigated further using known Bayesian tools and other tailored metrics, facilitating a more objective assessment of stellar activity intensity within each system. Our findings reveal that stellar activity contaminates up to half of the studied exoplanet atmospheres, albeit at varying extents. Accounting for stellar activity can significantly alter planetary atmospheric parameters like molecular abundances (up to 6 orders of magnitude) and temperature (up to 145%), contrasting with the results of analyses that neglect activity. Our results emphasize the importance of considering the effects of stellar contamination in exoplanet transit studies; this issue is particularly true for data sets obtained with facilities that do not cover the optical and/or UV spectral range where the activity is expected to be more impactful but also more easily detectable. Our results also provide a catalog of potentially active stars for further investigation and monitoring.
Monster Radio Jet (>66 kpc) Observed in Quasar at z ∼​​​​​ 5
Authors: Gloudemans Anniek J. , Sweijen Frits , Morabito Leah K. , Farina Emanuele Paolo , Duncan Kenneth J. , Harikane Yuichi , Röttgering Huub J. A. , Saxena Aayush , Schindler Jan-Torge 
Published: February 2025

Abstract
We present the discovery of a large extended radio jet associated with the extremely radio-loud quasar J1601+3102 at z ∼​​​​​ 5 from subarcsecond resolution imaging at 144 MHz with the International LOFAR Telescope. These large radio lobes have been argued to remain elusive at z > 4 due to energy losses in the synchrotron emitting plasma as a result of scattering of the strong cosmic microwave background at these high redshifts. Nonetheless, the 0

.

′

′

3 resolution radio image of J1601+3102 reveals a northern and a southern radio lobe located at 9 and 57 kpc from the optical quasar, respectively. The measured jet size of 66 kpc makes J1601+3102 the largest extended radio jet at z > 4 to date. However, it is expected to have an even larger physical size in reality due to projection effects brought about by the viewing angle. Furthermore, we observe the rest-frame UV spectrum of J1601+3102 with Gemini/GNIRS to examine its black hole properties, which results in a mass of 4.5 × 108
M
⊙ with an Eddington luminosity ratio of 0.45. The black hole mass is relatively low compared to the known high-z quasar population, which suggests that a high black hole mass is not strictly necessary to generate a powerful jet. This discovery of the first ∼​​​​​100 kpc radio jet at z > 4 shows that these objects exist despite energy losses from inverse Compton scattering and can put invaluable constraints on the formation of the first radio-loud sources in the early Universe.