bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laparoscopic liver resection versus radiofrequency ablation for caudate lobe solitary hepatocellular carcinoma: A propensity score matching study
Authors: Wang Zhengzheng , Ouyang Jingzhong , Jia Binyang , Zhou Yanzhao , Yang Yi , Li Xiaoting , Li Qingjun , Zhou Jinxue 
Published: March 2024

AbstractObjectiveThis study aimed to compare the clinical efficacy of laparoscopic liver resection (LLR) and radiofrequency ablation (RFA) in treating solitary hepatocellular carcinoma (HCC) of the hepatic caudate lobe.MethodsPatients with hepatic caudate lobe HCC who underwent LLR or RFA at three hospitals in China between February 2015 and February 2021 were included. In total, 112 patients met the inclusion criteria, of whom 52 underwent RFA and 60 underwent LLR. The outcomes of the two groups were compared and analyzed using propensity score matching (PSM) method.ResultsThere were no significant differences between the two groups in terms of sex, HBV/HCV positivity, AFP positivity (>100 ng/mL), tumor position, Child–Pugh score, or preoperative liver function tests (ALT, AST, TBIL, ALB, and PT) (p > 0.05). Compared to the LLR group, the RFA group had a shorter operation time, less intraoperative bleeding, and shorter postoperative hospital stay (p < 0.05). There was no statistically significant difference in overall postoperative complications between the two groups (p > 0.05). Despite the larger tumor size, the LLR group had better postoperative recurrence‐free survival (RFS) (p = 0.00027) and overall survival (OS) (p = 0.0023) than the RFA group. After one‐to‐one PSM, 31 LLR patients and 31 RFA patients were selected for further analyses. The advantages of LLR over RFA were observed in terms of RFS (p < 0.0001) and OS (p = 0.00029).ConclusionLLR should probably be recommended as the preferred method for solitary caudate lobe HCC.
Psoas muscle area is an independent survival prognosticator in patients undergoing surgery for long‐bone metastases
Authors: Lee Chia‐Che , Tseng Ting‐En , Chang Ruey‐Feng , Yen Hung‐Kuan , Chen Yu‐An , Chen Yu‐Yung , Wu Chih‐Horng , Hu Ming‐Hsiao , Yen Mao‐Hsu , Bongers Michiel , Groot Olivier Q. , Lai Cheng‐Yo , Lin Wei‐Hsin 
Published: March 2024

AbstractBackgroundPredictive analytics is gaining popularity as an aid to treatment planning for patients with bone metastases, whose expected survival should be considered. Decreased psoas muscle area (PMA), a morphometric indicator of suboptimal nutritional status, has been associated with mortality in various cancers, but never been integrated into current survival prediction algorithms (SPA) for patients with skeletal metastases. This study investigates whether decreased PMA predicts worse survival in patients with extremity metastases and whether incorporating PMA into three modern SPAs (PATHFx, SORG‐NG, and SORG‐MLA) improves their performance.MethodsOne hundred eighty‐five patients surgically treated for long‐bone metastases between 2014 and 2019 were divided into three PMA tertiles (small, medium, and large) based on their psoas size on CT. Kaplan–Meier, multivariable regression, and Cox proportional hazards analyses were employed to compare survival between tertiles and examine factors associated with mortality. Logistic regression analysis was used to assess whether incorporating adjusted PMA values enhanced the three SPAs' discriminatory abilities. The clinical utility of incorporating PMA into these SPAs was evaluated by decision curve analysis (DCA).ResultsPatients with small PMA had worse 90‐day and 1‐year survival after surgery (log‐rank test p < 0.001). Patients in the large PMA group had a higher chance of surviving 90 days (odds ratio, OR, 3.72, p = 0.02) and 1 year than those in the small PMA group (OR 3.28, p = 0.004). All three SPAs had increased AUC after incorporation of adjusted PMA. DCA indicated increased net benefits at threshold probabilities >0.5 after the addition of adjusted PMA to these SPAs.ConclusionsDecreased PMA on CT is associated with worse survival in surgically treated patients with extremity metastases, even after controlling for three contemporary SPAs. Physicians should consider the additional prognostic value of PMA on survival in patients undergoing consideration for operative management due to extremity metastases.
Perceiving a need for dietary change in adults living with and beyond cancer: A cross‐sectional study
Authors: Smith Susan , Fisher Abi , Lally Phillippa J. , Croker Helen A. , Roberts Anna , Conway Rana E. , Beeken Rebecca J. 
Published: March 2024

AbstractBackgroundMany people living with and beyond cancer (LWBC) do not meet dietary recommendations. To implement a healthier diet, people LWBC must perceive a need to improve their diet.MethodsParticipants included people diagnosed with breast, prostate or colorectal cancer in the UK. Two binary logistic regression models were conducted with perceived need for dietary change as the outcome (need to improve vs. no need). Predictor variables included demographic and clinical characteristics, receipt of dietary advice, and either body mass index (BMI) or adherence to seven relevant World Cancer Research Fund (WCRF) dietary recommendations.ResultsThe sample included 5835 responses. Only 31% perceived a need to improve their diet. Being younger (odds ratio [OR] 0.95, 95% confidence interval [CI] = 94–0.95), female (OR = 1.33, 95% CI = 1.15–1.53), not of white ethnicity (OR = 1.8, 95% CI = 1.48–2.27), not married/cohabiting (OR = 1.32, 95% CI = 1.16–1.52) and having received dietary advice (OR = 1.36, 95% CI = 1.43–1.86) was associated with an increased odds of perceiving a need to improve diet. This association was also seen for participants with two or more comorbidities (OR = 1.31, 95% CI = 1.09–1.57), those not meeting the recommendations for fruit and vegetables (OR = 0.47, 95% CI = 0.41–0.55), fat (OR = 0.67, 95% CI = 0.58–0.77), and sugar (OR = 0.86, 95% CI = 0.75–0.98) in the dietary components model and those who had a higher BMI (OR = 1.53, 95% CI = 1.32–1.77) in the BMI model.ConclusionsMost of this sample of people LWBC did not perceive a need to improve their diet. More research is needed to understand the reasons for this and to target these reasons in dietary interventions.
Pathologic complete response in patients with esophageal cancer receiving neoadjuvant chemotherapy or chemoradiation: A systematic review and meta‐analysis
Authors: Gaber Charles E. , Sarker Jyotirmoy , Abdelaziz Abdullah I. , Okpara Ebere , Lee Todd A. , Klempner Samuel J. , Nipp Ryan D. 
Published: March 2024

AbstractBackgroundNeoadjuvant chemoradiation and chemotherapy are recommended for the treatment of nonmetastatic esophageal cancer. The benefit of neoadjuvant treatment is mostly limited to patients who exhibit pathologic complete response (pCR). Existing estimates of pCR rates among patients receiving neoadjuvant therapy have not been synthesized and lack precision.MethodsWe conducted an independently funded systematic review and meta‐analysis (PROSPERO CRD42023397402) of pCR rates among patients diagnosed with esophageal cancer treated with neoadjuvant chemo(radiation). Studies were identified from Medline, EMBASE, and CENTRAL database searches. Eligible studies included trials published from 1992 to 2022 that focused on nonmetastatic esophageal cancer, including the gastroesophageal junction. Histology‐specific pooled pCR prevalence was determined using the Freeman–Tukey transformation and a random effects model.ResultsAfter eligibility assessment, 84 studies with 6451 patients were included. The pooled prevalence of pCR after neoadjuvant chemotherapy in squamous cell carcinomas was 9% (95% CI: 6%–14%), ranging from 0% to 32%. The pooled prevalence of pCR after neoadjuvant chemoradiation in squamous cell carcinomas was 32% (95% CI: 26%–39%), ranging from 8% to 66%. For adenocarcinoma, the pooled prevalence of pCR was 6% (95% CI: 1%–12%) after neoadjuvant chemotherapy, and 22% (18%–26%) after neoadjuvant chemoradiation.ConclusionsUnder one‐third of patients with esophageal cancer who receive neoadjuvant chemo(radiation) experience pCR. Patients diagnosed with squamous cell carcinomas had higher rates of pCR than those with adenocarcinomas. As pCR represents an increasingly utilized endpoint in neoadjuvant trials, these estimates of pooled pCR rates may serve as an important benchmark for future trial design.
Clinicopathological and genomic features of superficial esophageal squamous cell carcinomas in nondrinker, nonsmoker females
Authors: Fukuhara Motomitsu , Urabe Yuji , Nakahara Hikaru , Ishikawa Akira , Ishibashi Kazuki , Konishi Hirona , Mizuno Junichi , Tanaka Hidenori , Tsuboi Akiyoshi , Yamashita Ken , Hiyama Yuichi , Takigawa Hidehiko , Kotachi Takahiro , Yuge Ryo , Hayes C. Nelson , Oka Shiro 
Published: March 2024

AbstractBackgroundEsophageal squamous cell carcinoma (ESCC) is sometimes detected in non‐drinker and non‐smoker females who are considered to have very low risk of ESCC development in daily practice. This study examined the clinicopathological and genomic characteristics of ESCCs in females with no history of drinking and smoking.MethodsThe sample comprised 118 ESCC lesions occurring in 95 female patients who underwent endoscopic submucosal dissection at our department between January 2008 and December 2019. The patients were categorized into two groups: 51 lesions in 49 patients with no history of drinking and smoking (nondrinker/nonsmoker [NDNS] group) and 69 lesions in 45 patients with a history of drinking or smoking (drinker/smoker [DS] group). We analyzed the differences in clinicopathological and cancerous genomic characteristics between the groups. Significant genomic alterations were validated using immunohistochemistry.ResultsMultiple logistic regression revealed that older age, fewer multiple Lugol‐voiding lesions (LVLs), and reflux esophagitis (RE) were independently associated with the occurrence of ESCCs in the NDNS group. ESCC lesions in the NDNS group were predominantly located in the mid‐thoracic esophagus, posterior wall side, with 0‐IIa, the aspect ratio of the lesion >2 (vertical/horizontal), and endoscopic keratinization. Genetic analysis showed that CDKN2A driver alterations were significantly more frequent and KMT2D alterations were significantly less frequent in the NDNS group than in the DS group. KMT2D alterations were strongly correlated with immunostaining.ConclusionOlder nondrinker, nonsmoker females with RE and fewer multiple LVLs may develop longitudinal 0‐IIa ESCC with keratinization of the posterior wall of the mid‐thoracic esophagus. ESCCs in nondrinker, nonsmoker females had fewer KMT2D alterations and more CDKN2A alterations, which may be a biomarker for treatment.
Exploring the emerging bidirectional association between inflamm‐aging and cellular senescence in organismal aging and disease
Authors: Sharma Rohit 
Published: March 2024

AbstractThere is strong evidence that most individuals in the elderly population are characterized by inflamm‐aging which refers to a subtle increase in the systemic pro‐inflammatory environment and impaired innate immune activation. Although a variety of distinct factors are associated with the progression of inflamm‐aging, emerging research is demonstrating a dynamic relationship between the processes of cellular senescence and inflamm‐aging. Cellular senescence is a recognized factor governing organismal aging, and through a characteristic secretome, accumulating senescent cells can induce and augment a pro‐inflammatory tissue environment that provides a rationale for immune system‐independent activation of inflamm‐aging and associated diseases. There is also accumulating evidence that inflamm‐aging or its components can directly accelerate the development of senescent cells and ultimately senescent cell burden in tissues in a likely vicious inflammatory loop. The present review is intended to describe the emerging senescence‐based molecular etiology of inflamm‐aging as well as the dynamic reciprocal interactions between inflamm‐aging and cellular senescence. Therapeutic interventions concurrently targeting cellular senescence and inflamm‐aging are discussed and limitations as well as research opportunities have been deliberated. An effort has been made to provide a rationale for integrating inflamm‐aging with cellular senescence both as an underlying cause and therapeutic target for further studies.
Examining the relationship between Hispanic Serving Community college Title III grants and STEM associate degree completion
Authors: Corral Daniel , Rahim Daniyal 
Published: March 2024

AbstractHispanic‐Serving Community Colleges enroll and educate a large share of Hispanic postsecondary students. Due to work trends and demographic changes, Hispanic and other historically underrepresented students play a crucial role in shaping the next generation of Science, Technology, Engineering, and Math (STEM) scholars and practitioners. We use data from the National Center for Education Statistics and a difference‐in‐differences technique to estimate the association between federal capacity building grants aimed at improving STEM degree attainment outcomes and associate degree completion. We find receipt of a Title III grant was associated with about a 30% increase in the total number of STEM associate degrees awarded. Further, the grants nearly doubled the number of STEM associate degrees awarded to Hispanic students, on average. This positive relationship is driven by institutions receiving more than one grant. We conclude by discussing these findings and providing federal and institutional recommendations.
Blurring the lines to promote access and equity in 2‐ and 4‐year Hispanic serving institutions
Authors: Hinojosa Denisse M. , Bonner Emily P. , Hunt Heidi , Devine Bailey 
Published: March 2024

AbstractPartnerships between two‐ and four‐year Hispanic Serving Institutions (HSI) can provide high‐quality, in‐depth learning experiences for traditionally underserved students. Blurring the lines between these institutions allows for more seamless transitions for prospective teachers (PTs), and maximum collaboration and program impact. This article contributes to the growing literature on such partnerships and collaborations. We describe how our partnership between Northwest Vista College (2‐year institution) and University of Texas at San Antonio (4‐year institution) supported PTs and their development of mathematics pedagogical content knowledge and skills to facilitate in diverse settings (i.e., mathematics sensemaking, questioning, teaching through problem solving, soft teaching skills). To describe the nature of our partnership, in this article we (1) explain some of the main elements of the partnership between the two‐ and four‐year campuses, (2) review the unique, collaborative nature of the Community Mathematics Project, and (3) discuss outcomes that have resulted among Mathematics Fellows who have gone through the program.
Effective coalitions in redesigning teacher education
Authors: Casale Carolyn , Clippert‐deVogel Sherry , Scheuer Cynthia 
Published: March 2024

AbstractA diverse stakeholder partnership led to the development of a Pre‐Elementary Education program through its collaboration among faculty, academic advisement, and administration across higher education institutions. Housed at an institution that serves a minority population, this collaboration led to offering an Associate of Arts degree that is fully (2 + 2) transferrable to three key transfer universities. This collaboration also created a credit hour transfer pathway to a prominent Research I institution utilizing a Mellon grant partnership between the two institutions. These collaborations are significant because pre‐education is a transfer degree and requires completion of a bachelor's degree program to meet state certification requirements. This partnership emerged in 2021–2022 at a prominent Midwestern community college. This article resports on the process of building the Pre‐Elementary Associate of Arts degree. The student population is considered minority status, being first‐generation, lower socio‐economic, coming from black and brown communities, and Middle Eastern North African descent. The lessons learned are that forging collaboration among academic advisement, faculty, and administration leads to a more successful student experience through the creation of a highly transferrable program.
“Not simply the act of enrolling”: Defining servingness at Hispanic‐serving community colleges
Authors: Lujan Jarett , McNaughtan Jon , Williams Brittani 
Published: March 2024

AbstractThe number of federally designated Hispanic serving institutions (HSIs) has almost doubled over the last 10 years. This shift has led researchers and policy makers alike to increasingly scrutinize what it means to be Hispanic serving, and not just Hispanic enrolling. In this study, we present perspectives from five Hispanic community college presidents who lead federally designated HSIs. Based on interviews we examine how community college presidents define servingness and what they view as critical to truly serving Hispanic students. Our findings indicate that servingness involves a focus on getting resources to students, intentional purpose‐driven programming, cultural knowledge training, and finding ways to include all students in HSI‐centered programming.
What's not in the grant: An exploration of project directors’ experiences at two‐year Asian American and Native American Pacific Islander serving institutions in the Midwest
Authors: Mac Jacqueline , Aunaetitrakul Dear , Xiong Nhia 
Published: March 2024

AbstractThis article explores the experiences of project directors at two‐year Asian American and Native American Pacific Islander serving institutions in the Midwest. Specifically, we examined how project directors faced racialized campus environments, navigated support structures (or the lack thereof), and continually combatted misperceptions about the Asian American and Pacific Islander (AA/PI) communities and the Midwest. We discussed the isolation, myths, lack of institutional support, and campus climate for project directors and AA/PI communities. We end with recommendations.
Post‐operative arrest following pectus excavatum repair: A case report with a systematic review of the published case reports
Authors: Roostaei Ghazal , Amini Hesam , Abtahi Hamidreza , Kazemizadeh Hossein , Edalatifard Maryam , Rahimi Besharat , Asadi Sanaz , Khoshnam‐Rad Niloofar 
Published: March 2024

Key Clinical MessageCommon complications after PE surgery include ventricular tachycardia, cardiac arrest, pneumothorax, and bar displacement. These can lead to severe outcomes, emphasizing the need for caution and meticulous post‐operative monitoring. Patients and their families should be well‐informed about potential risks during the consent process.AbstractThe objective of this study was to raise awareness among medical staff and surgeons about potential complications, particularly rare and life‐threatening ones, associated with pectus excavatum (PE) surgery. PE is the most common chest wall deformity, characterized by sternal depression. Patients primarily seek treatment for cosmetic concerns, but some also report exercise intolerance and shortness of breath. Although surgical repair is the standard treatment, the incidence and nature of severe complications remain unclear and underreported. This study presents a case of a lethal cardiac event following PE surgery and conducts a systematic review of published case reports. This study describes a case of a lethal complication of ventricular fibrillation and cardiac arrest following the Ravitch procedure for correction of PE in a 10‐year‐old boy. A systematic review of relevant cases of PE surgery complications was conducted. Of the 506 initial records retrieved, 93 case reports from 83 articles were identified over the 23 years. Among them, 72 patients were male, and 20 cases were female. The average age of patients was 19.2 ± 7.7 years (range: 5–53). Complications had occurred up to 37 years from the time of surgery, with most of the cases (22.5%) occurring during the operation. The most frequent complications included cardiothoracic issues and displacement of the implanted steel bar. In nine patients, complications led to fatal outcomes. Due to the possible risks of PE surgery, particularly in cosmetically motivated cases, surgeons must exercise extreme caution and remain vigilant for rare and potentially life‐threatening complications.
Pulmonary coccidioidomycosis mimicking malignancy associated with Sweet's syndrome (acute febrile neutrophilic dermatosis)
Authors: Chaisrimaneepan Nattanicha , Guadarrama Austin , Yingchoncharoen Pitchaporn , Batchinsky Maria 
Published: March 2024

Key clinical messageA suspicious malignant lung nodule with cutaneous reaction is not always cancer, especially in low risk for malignancy patients. A lung biopsy should be taken into consideration. The associated cause of Sweet's syndrome directs the treatment in each patient.
Dual‐Responsive Gradient Structured Actuator via Photopolymerization‐Induced Diffusion
Authors: Sezen Polat Duygu , Buurman Vera E. , Mulder Dirk J. , Liu Danqing 
Published: March 2024

AbstractStimuli‐responsive materials have recently gained significant attention in the field of soft robotics, sensors, and biomimetic devices. The most facile way for the fabrication of such materials remains to endow bilayer structures which are fabricated with the combination of active and passive layers. Although, easily fabricated, these structures suffer from the generation of stress points between connection areas. In this work we develop a method to create a thin film with controlled cross‐link variation across its thickness. The cross‐link gradient is achieved through polymerization induced diffusion of dithiol molecules in thiol‐ene network. As a result, the film exhibits bending deformation upon illumination with light or exposure to a chemical solvent, thereby demonstrating dual responsiveness. Light actuation of the film is achieved via photothermal effects due to the incorporation of dye into the system which can absorb UV light and heat the network. While solvent induced actuation is due to anisotropic swelling. Furthermore, the straightforward fabrication procedure allows for the creation of more complex deformations by patterning the film using a photomask during photopolymerization.