bluuebunny/crossref_metadata_2025_split huggingface dataset:
Smoking is not associated with wound complications in augmented urethroplasty: A NSQIP Analysis
Authors: Cahill Ellen , Islam Raeesa , Chua Kevin , Balraj Vasundhara , Boyle Joseph , Patel Hiren , Kaldany Alain , Doppalapudi Sai Krishnaraya , Velez Danielle , Tunuguntla Hari , Sterling Joshua 
Published: April 2024

Abstract

Objective
To investigate if predictors of wound complications differed between patients undergoing excision and primary anastomosis urethroplasty (EPA) and augmented urethroplasty.
Methods
The National Surgical Quality Improvement Program database from 2006–2018 was queried for male patients undergoing urethroplasty. Thirty-day wound complications were identified and categorized (superficial/deep/organ-space surgical site infections and dehiscence). Multivariable logistic regression was performed to determine risk factors associated with wound complications. Smoking history was defined as current smoker within the past year.
Results
Urethroplasty was performed in 2251 males, with 25.46% (n = 573) using a flap or graft. There was no significant difference in wound complications for patients undergoing augmented urethroplasty (n = 17, 2.97%) or EPA (n = 45, 2.68%) (p = 0.9). The augmented group had a higher BMI, longer operative time, and longer length of stay. On multivariable logistic regression, risk factors associated with wound complications for patients undergoing EPA were diabetes (OR 2.56, p = 0.03) and smoking (OR 2.32, p = 0.02). However, these factors were not associated with wound complications in patients undergoing augmented urethroplasty.
Conclusions
Smoking and diabetes were associated with increased wound complications for men undergoing EPA, but not in patients undergoing augmented urethroplasty. Patients with comorbidities associated with worse wound healing may be more likely to have a wound complication when undergoing EPA.
Real-World Cost-analysis of Paliperidone Palmitate for Schizophrenia Management:A Retrospective Analysis in Xiamen, China
Authors: Zhou Yixiang , Chen Binbin , Huang Yinghua 
Published: April 2024

Abstract

Background: To perform a cost-analysis of one-year maintenance treatment in stable schizophrenic patients with paliperidone extended-release tablets (PPER) and paliperidone palmitate once-monthly (PP1M) and provide a reference for clinicians in patient selection.
Methods: A retrospective investigation and analysis were conducted on stable schizophrenic patients who had been on PPER or PP1M for at least one year between June 2014 and December 2019 in Xiamen City. Patient demographic data, direct medical and nonmedical costs, and other information were collected. The clinical efficacy data were obtained from published articles, and a cost-effectiveness analysis was conducted.
Results: The PPER and PP1M groups included data from 84 and 62 patients, respectively. The two groups had no significant difference in gender and age. The total effective rates of PPER and PP1M were 73.17 and 97.37%, respectively. The registration frequency in the PPER group was significantly higher than that in the PP1M group (P<0.001). The cost of medication and total treatment was significantly higher in the PP1M group than in the PPER group (P <0.001). The cost/effect value was slightly higher in the PP1M group than in the PPER group. The incremental cost-effect ratio of both treatments was 369.07 yuan, less than the per capita gross domestic product (GDP) value.
Conclusion: Both formulations of paliperidone were found to be suitable for the long-term management of schizophrenia, while PP1M has better pharmacoeconomic advantages.
Purulent Pericarditis Caused by Nocardia: A Case Report and Literature Review
Authors: Zhong Xinxin , Lin Ao , Luo Jian , Jiang Shihao , Ruan Yuying , Li Shuting , Zhong Li , He[Author] zhiyi , Cao Fu 
Published: April 2024

Abstract
Background
Pericarditis caused by Nocardia, a rare opportunistic disease marked by high mortality rates, is frequently misdiagnosed as Mycobacterium tuberculosis (MTB) and bacterial infections.
Case Presentation:
We present a case of pericarditis caused by Nocardia in a patient with acquired immune deficiency syndrome(AIDS). The patient was misdiagnosed on several occasions and received inappropriate anti-tuberculosis treatment for MTB. When timely pericardial puncture and collection of pericardial effusions culture revealed the presence of Nocardia, the patient was started on appropriate antibiotic therapy, which resulted in a cure.
Conclusions
By reporting this case, we aim to enhance clinicians' awareness of the differential diagnosis of purulent pericarditis and the importance of sensitive antibiotic therapy to aid in the timely diagnosis and treatment of nocardial pericarditis. The previously reported cases of laboratory-confirmed nocardial pericarditis are also reviewed and summarized.
Forest-based Approaches for SDR
Authors: Dai Shuang , Wu Ping , Yu Zhou 
Published: April 2024

Abstract

Sufficient dimension reduction (SDR) primarily aims to reduce the dimensional-ity of high-dimensional predictor variables while retaining essential informationabout the responses. Traditional SDR methods generally employ kernel weightingfunctions, which unfortunately makes them prone to the curse of dimensional-ity. To address this issue, this paper applies Random Forests as an adaptiveweighted technique for SDR problems, thereby resulting in both improved computational efficiency and predictive accuracy. In the central mean subspace model,by combining the study of Xia et al. (2002) with Mondrian forest weights, wesuggest the forest-based outer product of gradients estimation (mf-OPG) andthe forest-based minimum average variance estimation (mf-MAVE). Moreover, we implement the forest-based techniques (mf-dOPG and mf-dMAVE) to estimate the central subspace based on the study of Xia (2007). Under regularityconditions, we establish the asymptotic properties of the forest-based estimators, as well as the convergence of the affiliated algorithms. The practical efficacy of our proposals is demonstrated via simulation studies and empirical data analysis.Moreover, for a more comprehensive representation, we compare the numericalperformance of forest-based approaches with tree-based methodologies.
Multichannel meta-imager for parallel front-end optical computations
Authors: Li Peng , Bi Xinyi , Wu Xuanguang , Fan Xinhao , Zhao Chenyang , Wen Dandan , Liu Sheng , Gan Xuetao , Zhao Jianlin 
Published: April 2024

Abstract
Optical computing has demonstrated significant advantages over electronic computing, including parallelism, high-speed processing, extensive capacity, and low energy consumption. Optical computing front ends leveraging metasurfaces provide advantages such as miniaturization and seamless integration, but have a serious constraint of single computing functionality. Here, we propose a meta-imager, optical computing front end that integrates two coherent transfer functions corresponding to differential and integral convolution kernels into a built-in metasurface. In this architecture, the meta-imager enables parallel processing of multiple all-optical operations for signal computing tasks such as edge enhancement and denoising. We demonstrate the robust integral and differential operations on image signals of noisy patterns and onion cells at multiple visible wavelengths. This optical computing meta-imager paves a promising pathway towards multifunctional image processing for artificial intelligence and biological observation, and shows the potential to expedite and potentially supplant certain digital neural network algorithms.
Måleegenskaper ved den norske versjonen av Preschool Anxiety Scale – Revised (PAS-R)
Authors: Backer-Grøndahl Agathe , Helland Siri Saugestad 
Published: April 2024

Beskrivelse: Preschool Anxiety Scale – Revised (PAS-R; Edwards, Rapee, Kennedy & Spence, 2010) er et instrument som måler et bredt spekter av angstsymptomer hos førskolebarn. PAS-R består av 28 ledd som til sammen måler sosial angst, generalisert angst, separasjonsangst og spesifikke fobier. Instrumentet er oversatt til norsk av Ørbeck, Eyre og Kristensen i 2013. PAS-R kan brukes kostnadsfritt av forskere og klinikere.
Litteratursøk: Et systematisk litteratursøk etter norske, danske og svenske studier som rapporterte psykometriske egenskaper for PAS-R resulterte i en masteroppgave og en hovedoppgave. Disse var basert på tverrsnittsdata fra et normalutvalg av førskolebarn i en pilotundersøkelse (N = 37) og i hovedstudien (N = 260) i Norwegian Tuning in to Kids ved Universitetet i Oslo.
Psykometri: Middelverdiene for PAS-R var i de to studiene presentert med en annen skalering enn i originalskalaen, og disse ble derfor omregnet for å muliggjøre sammenligning med internasjonale funn. Resultatene indikerte god reliabilitet (indre konsistens) for totalskalaen. Gjennomsnittsverdiene for totalskalaen i de norske utvalgene var lavere enn i det originale utvalget, men høyere enn i et islandsk utvalg. Det ble ikke rapportert psykometridata for delskalaene i de to norske studiene.
Konklusjon: Vi har begrenset datagrunnlag for å konkludere om de psykometriske egenskapene ved den norske versjonen av PAS-R. Til tross for dette vil vi oppmuntre til bruk av PAS-R i norske forskningsstudier, da dette er et av få instrumenter som fanger ulike angstdimensjoner hos barn og da det bør forskes på PAS-R fordi det er behov for økt kunnskap om instrumentets psykometriske egenskaper.
Assessment of climate change impacts on rainfall and streamflow in the Alto Paranapanema Basin, Brazil
Authors: Hucke André Teixeira da Silva , Menegaz Mateus Nardini , Isidoro Jorge Manuel Guieiro Pereira , Tiezzi Rafael de Oliveira 
Published: April 2024

ABSTRACT

Climate change has the potential to fundamentally transform landscapes on global scale. Leveraging advanced predictive modeling to enhance water resource management within the Alto Paranapanema Basin (Brazil), holds the potential to proactively anticipate challenges and alleviate the impacts and conflicts arising from this phenomenon. This is particularly important in a region boasting over 1,600 centerpivot irrigation systems. This study employs the Soil Moisture Accounting Procedure, a physical model, to simulate long-term climate datasets and flows. Future climate scenarios, rooted in the Representative Concentration Pathways, are developed through the downscaling of Global Climate Models. The findings reveal a temporal shift in rainfall patterns, characterized by a reduction during the wet season of up to 40% compared to the average historical rainfall, and an increase throughout the dry season up to 40% compared to the same historical, estimated by the Eta -BESM model. These changes present challenges regarding to water availability, hydroelectric generation, and agricultural. By fostering collaboration among different governmental entities responsible for the managements of basins and harnessing the potential of predictive models, this research advocates for the adoption of proactive strategies in management of water resources. These strategies are imperative to effectively counteract the far-reaching effects of climate change.
Network Pharmacology Combined with Molecular Docking Approach to Investigate
the Mechanism of ChuShiWeiLing Decoction against Perianal Eczema
Authors: Liu Ying , Hao Min , Fang Xinyue , Qian Yifei , Wang Yahui , Yan Shuai 
Published: April 2024

Background:
ChuShiWeiLing Decoction (CSWLD) is a famous classical Chinese prescription for
the treatment of eczema with desirable effect in clinical practice. It has gradually exerted good curative effects
on perianal eczema (PE) in recent years, but its specific mechanism is not elucidated yet.

Objective:
This research explores the underlying pharmacological mechanism of CSWLD in addressing PE
through network pharmacology combined with molecular docking strategy.

Methods:
The key chemical compounds and potential target genes of CSWLD were screened by bioinformatics.
The major targets of CSWLD were discovered using network modules. Functional annotation of Gene
Ontology (GO) was undertaken, as well as pathway enrichment analysis using the Kyoto Encyclopedia of
Genes and Genomes (KEGG). Molecular docking of core protein-ligand interactions was modeled using AutoDock
software. Pymol software was used to perform a molecular dynamics simulation for the ideal core
protein-ligand that was discovered by molecular docking.

Results:
A total of 2,853 active compounds and 922 targets of CSWLD were collected. The target with a
higher degree was identified through the PPI network, namely TNF, IL6, ALB, STAT3, EGFR, TLR4,
CXCL8 and PTPRC. GO and KEGG analyses suggested that CSWLD treatment of PE mainly involves cellular
activation, activation of leukocytes, and adhesion among leukocytes. The molecular docking results
showed that wogonin, hederagenin and quercetin of CSWLD could bind to IL-6 and TNF, respectively.

Conclusion:
Our results indicated that the bioactives, potential targets, and molecular mechanism of CSWLD
against PE.
Hemisynthesis of Pentacyclic Triterpenoids from Diospyros foxworthyi with In vitro
and In silico Anti-malarial Evaluation
Authors: Abd Ghani Muhammad Solehin , Abu Bakar Nur Ain Latifhaa , Ramadani Arba Pramundita , Nugraha Arde Toga , Awang Khalijah Binti , Che Omar Mohammad Tasyriq , Supratman Unang , Kamarulzaman Ezatul Ezleen , Mohamad Taib Mohamad Nurul Azmi 
Published: April 2024

Abstract:
A total of twelve pentacyclic triterpenoid derivatives based on betulin (1) and lupeol (2) scaffolds
isolated from Diospyros foxworthyi were hemisynthesized by acylation or acetylation reactions with appropriate
acid chloride or acetic anhydride. The structures of the hemisynthesised compounds were characterised by
means of FT-IR, 1D- and 2D-NMR, as well as HRMS analysis. These compounds were assayed for in vitro
anti-malarial studies by inhibition of β-hematin formation assay with chloroquine as a positive control. Compounds
1d and 2f showed the strongest potential as β-hematin formation inhibitors with IC50 values of 6.66 ±
1.36 and 11.89 ± 0.15 μM, respectively, compared with the positive control (chloroquine; IC50 = 37.50 ± 0.60
μM). In silico molecular docking simulations were performed using AutoDock Vina for compounds 1d and 2f
to investigate the binding interactions and free energy of binding (FEB) with the hemozoin supercell crystal
structure (CCDC number: XETXUP01). The findings revealed several hydrophobic interaction modes between
the 1d, 2f and hemozoin, with calculated FEBs of -8.4 ± 0.2 and -8.9 ± 0.0 kcal mol-1, indicating strong and
favourable interactions.
Recent Developments in Asymmetric Nazarov Reactions
Authors: Pellissier Hélène 
Published: April 2024

Abstract:
The Nazarov reaction involves the cyclization of divinyl ketones into cyclopentenones
under the influence of strong acids. The prevalence of five-membered carbocycles
in a multitude of natural and bioactive products has triggered an intense development of
efficient methods for their construction. In particular, asymmetric versions of the Nazarov
reaction are achieved by using either a chiral auxiliary or a chiral catalyst, which can be an
organocatalyst, a metal catalyst, or a multicatalytic system. This review aims to update the
field of asymmetric Nazarov reactions published since 2017. It is divided into four sections,
dealing successively with Nazarov reactions of chiral auxiliaries, organocatalytic
enantioselective Nazarov reactions, metal/boron-catalyzed enantioselective Nazarov reactions,
and multicatalytic enantioselective Nazarov reactions. Each section of the review is
subdivided into simple asymmetric Nazarov reactions and Nazarov-based domino/tandem reactions, which
have allowed numerous more complex functionalized chiral molecules to be synthesized in one-pot procedures.
Organocatalyst 1,4-diazabicyclo [2.2.2]octane (DABCO)-catalyzed Sustainable
Synthesis of Bis-thiazolidinones Derivatives and their Spectral and DFT Analysis
Authors: Sahal Saloni , Chahar Mamta , Singh Har Lal , Bishnoi Renu , Khaturia Sarita 
Published: April 2024

Abstract:
Organocatalyst 1,4-diazabicyclo [2.2.2]octane (DABCO) has proven to be an efficient
and environmentally friendly catalyst in the multicomponent reaction involving aldehydes,
ethylenediamine, and thioglycolic acid under microwave conditions. DABCO stands
out among other organic catalysts due to its cost-effectiveness, non-toxic nature, and environmentally
conscious profile. The method employed in this study exhibited exceptional attributes,
such as high yields, swift reaction times, atom economy, catalyst reusability, and minimal
catalyst loading. Additionally, there were excellent yields of products (90-94%). The melting
points, UV-Vis, IR, 1HNMR, 13CNMR, were used to analyze the produced compounds. The invitro
antibacterial activity of the synthesized compounds was investigated against pathogenic
strains E. coli and Bacillus supstalis, and the results obtained were further explained with the help of DFT and
molecular orbital calculations. Moreover, the compound 4b was found to be the most potent antibacterial agent
amongst all tested compounds.
Investigating PI3P Binding with Plasmodium Falciparum HSP70 Proteins
Authors: Upadhyay Vipul , Kaur Satinder , Hora Rachna , Mishra Prakash Chandra 
Published: April 2024

Background:
Plasmodium falciparum (P. falciparum) heat shock proteins (PfHSP70s)
are an important class of molecules critically involved in parasite survival during stress. Interaction
between the cytosolic PfHSP70-1 and a crucial lipid modulator, Phosphatidylinositol 3 Phosphate
(PI3P), stabilizes the parasite Digestive Vacuole (DV) to facilitate hemoglobin trafficking
and breakdown, in turn impacting parasite survival.

Methods:
PI3P binding on PfHSP70-1 is facilitated by its C-terminal LID domain that controls
substrate binding. PI3P and PfHSP70 homologs are amply expressed together in various subcellular
compartments of the parasite, providing them with opportunities to interact and modulate biological
processes.

Results:
Here, we have identified and analyzed the PI3P binding pockets of all four PfHSP70s by
using structural bioinformatics tools to understand their interaction with this lipid. Our results
show that differently localized PfHSP70 homologs bind PI3P with variable affinity.

Conclusion:
Analysis of these results has also helped to pinpoint specific residues on PfHSP70s
that may be engaged in these interactions. The present study may, therefore, form the basis for designing
interventions that hinder PfHSP70-PI3P interaction and influence parasite survival.
Middle Lobe Syndrome: A Case Report and Literature Review
Authors: Sciuto Laura , Tosto Monica , Licciardello Laura , Giugno Andrea , Balconara Desiree , Mollica Federico , Mule Enza , Papale Maria 
Published: April 2024

Background:
Middle lobe syndrome (MLS) is a distinct clinical and radiographic entity
characterized by recurrent or chronic collapse of the middle lobe of the right lung, but it can also
involve the lingula of the left lung.

Case Study:
This study presents a rare case of MLS caused by a vascular ring never described in
the literature until now and provides physicians with the clinical and instrumental tools in order to
early recognize and promptly treat this condition. The case report was reported according to
CARE guidelines. A literature research on PubMed/MEDLINE was also performed using the
MeSH terms “Middle lobe syndrome OR MLS AND double aortic arch” “Middle lobe syndrome
OR MLS AND vascular rings”. No case described in the literature was found. In most cases, MLS
presents non-specific respiratory symptoms, which unfortunately is responsible for the diagnostic
delay that patients with this pathology often suffer. The diagnostic delay is estimated to be 8
months (range 3 to 36 months). A history of dysphagia and regurgitation can be indirect signs of a
vascular compression, such as vascular rings, which can cause MLS.

Conclusion:
To date, the reported case is the only case in the literature of MLS caused by double
aortic arch. The key point for the diagnosis of MLS is diagnostic suspicion. Early recognition of
MLS is essential to quickly start a targeted therapeutic program avoiding the persistence of vicious
circle atelectasis-recurrent respiratory infections, and this could significantly improve the
long-term outcome of these patients.
Enhancing Indoor Navigation for Visually Impaired Individuals with an
AI Chatbot Utilizing VEO Optimized Nodes and Natural Language
Processing
Authors: Thandu Nagaraju , Rathinam Murugeswari 
Published: April 2024

Aims and Background:
Visually impaired people face numerous challenges when it
comes to indoor navigation. While outdoor navigation benefits from advancements in GPS and related
technologies, indoor spaces present intricate, complex, and often less accessible environments
for those with visual impairments.

Objective and Methodology:
In response to these challenges, we propose an innovative approach
to enhance indoor navigation for individuals with visual impairments, leveraging the power of an
AI chatbot. Our AI chatbot employs cutting-edge artificial intelligence techniques to provide realtime assistance and guidance, facilitating independent navigation within intricate indoor settings.
By harnessing natural language processing technologies, the chatbot engages in intuitive interactions with users, comprehending their queries and offering detailed instructions for efficient indoor
navigation. The main goal of this research is to enhance the independence of people with visual
impairments by offering them a reliable and easily accessible tool.

Results and conclusion:
This tool, driven by our Volcano Eruption Optimization Network, promises
to significantly enhance the independence and overall indoor navigation experience for visually
impaired people, ultimately fostering a greater sense of autonomy in navigating complex indoor
spaces.
Advanced Gyrotron Concepts for Spectroscopic Applications
Authors: Zapevalov Vladimir Evgen'evich , Sergeevich Zuev Andrey 
Published: April 2024

Background:
Currently, some modern spectroscopic applications require sub-terahertz
and terahertz continuous-wave electromagnetic radiation sources with power levels from 0.1 to 100
W. Gyrotron, a powerful high-frequency vacuum electronics device, is considered one of the promising
sources for these aims.

Methods:
Modification of the gyrotron design promotes the widespread use of these devices for
DNP/NMR spectroscopy.

Results:
Promising non-canonical concepts are presented, the features of which compare favorably
with the classical gyrotron scheme.

Conclusion:
The gyrotron concepts we considered allow us to master the terahertz range and develop
a unique gyrotron installation for each scientific group, considering the specifics of their
scientific research.
Knowledge, Attitude and Practice (KAP) on Zakat Management in Higher Education
Authors: Bahori Adibah , Mohd Azli Rafidah , Yaakob Ahmad Faiz , Mohd Yunos Zulhilmi 
Published: April 2024

Zakat is a type of assistance designed to lessen the burden experienced by people in need. The zakat fund given to Universiti Teknologi MARA (UiTM) students has been managed by the Zakat, Sedekah, and Waqf Unit (ZAWAF). ZAWAF has shared crucial information about zakat via a web-based zakat application. However, some students were not well-informed about zakat distribution. The researchers were asked to look into it more deeply. A framework based on Knowledge, Attitude, and Practice (KAP) will be used to understand people's awareness of zakat management and further help to improve the existing ZAWAF delivery service at UiTM.