bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trabeculotomy Using the Kahook Dual Blade for Exfoliation Glaucoma and Primary Open Angle Glaucoma: Comparison of Outcomes According to Incision Range
Authors: Irie Anna , Nakashima Kei-Ichi , Inoue Toshihiro , Kojima Sachi , Takihara Yuji , Takahashi Eri 
Published: March 2024

Précis:
Large amount of trabeculotomy with Kahook Dual Blade (KDB) confers better intraocular pressure (IOP) lowering.

Purpose:
We compared the postoperative outcomes of trabeculotomy using the KDB in patients with exfoliation glaucoma (EXG) and primary open angle glaucoma between the 120-degree incision and the 210- to 240-degree incision groups.

Patients and Methods:
We retrospectively analyzed the postoperative outcomes of trabeculotomy performed using the KDB in 101 eyes with EXG and primary open angle glaucoma, who received 120- and 210- to 240-degree incisions at Kumamoto University Hospital between April 25, 2018, and August 11, 2021. Kaplan-Meyer survival curves were used to assess the outcomes. Surgical failure was defined as IOP ≥21 mm Hg (criterion A) and ≥19 mm Hg (criterion B), or an IOP ≤4 mm Hg in either criterion and the need for additional glaucoma surgery.

Results:
In total, 64 and 37 eyes were included in the 120 and 210- to 240-degree groups, respectively. The 210- to 240-degree group had a higher 1-year success rate compared with the 120-degree group, both when considering all eyes and when considering only those with EXG (P<0.05).

Conclusions:
In trabeculotomy with KDB, a 210- to 240-degree incision was more effective than a 120-degree incision in lowering IOP in EXG cases.
Long-Term Follow-Up of Myopic Glaucoma: Progression Rates and Associated Factors
Authors: Huh Min Gu , Shin Young In , Jeong Yoon , Kim Young Kook , Park Ki Ho , Jeoung Jin Wook 
Published: March 2024

Précis:
In the group of glaucoma patients with myopia, the more severe the degree of myopia, the faster the loss of visual acuity and central visual field defect.

Design:
Longitudinal observational study.

Objective:
To investigate the progression rate of myopic glaucoma and associated factors by long-term analysis of its clinical course.

Methods:
Patients who had had at least 5 years of follow-up and a spherical equivalent of –0.5 diopters or less were included in this study. They were divided into 3 myopia groups according to myopic grade, namely mild myopia (–0.5 to –3.0 diopters), moderate myopia (–3.0 to –6.0 diopters), and high myopia (–6.0 diopters or more), and the clinical course, progression rate, and associated factors were compared among the groups and analyzed.

Results:
A total of 121 eyes of 121 patients with glaucoma with myopia were included in the study. The average follow-up period was 10.4 ± 2.9 years. In the analysis of progression rate, the change rate of average retinal nerve fiber layer (RNFL) thickness (–0.75 μm/y in mild myopia, –0.82 μm/y in moderate myopia, –0.84 μm/y in high myopia) and the mean deviation change (–0.30 dB/y in mild myopia, –0.37 dB/y in moderate myopia, –0.39 dB/y in high myopia) both tended to be faster as the myopic grade increased. In a Kaplan-Meier survival analysis, the high myopia groups demonstrated a significantly faster VA loss (of more than 3 lines) and a higher incidence of newly developed central visual field defect (CVFD) than did the mild and moderate myopia groups. Longer axial length (odds ratio: 1.72, CI: 1.03–3.07, P = 0.047) and RNFL defect extending to the macula (odds ratio: 4.14, CI: 1.54–12.30, P = 0.007) were significantly associated with newly developed CVFD.

Conclusions:
In patients with myopic glaucoma, the higher the degree of myopia, the faster the rate of visual acuity loss and CVFD occurrence. Occurrence of CVFD was associated with longer axial length and widening of RNFLr defect to the macula.
Surgical Outcomes of Early Versus Late Onset Glaucoma Associated With Sturge-Weber Syndrome
Authors: Senthilkumar Vijayalakshmi A. , Prakash Sarvesswaran , Puthuran George Varghese , Uduman Mohammed Sithiq , Krishnadas Subbaiah Ramasamy , Gedde Steven Jon 
Published: March 2024

Précis:
Long-term intraocular pressure control can be difficult to achieve in eyes with Sturge-Weber syndrome glaucoma. The most commonly performed primary surgery was trabeculotomyin early onset disease and tube shunt implantation in late onset disease.

Purpose:
To compare long-term surgical outcomes of glaucoma associated with Sturge-Weber syndrome (SWS) in eyes with early and late-onset disease.

Methods:
Medical records of children with glaucoma associated with SWS who underwent surgical treatment between January 1990 and December 2018 were reviewed. Those diagnosed ≤2 years of age were categorized as early onset while those who were diagnosed >2 years of age were late onset. Failure was defined as intraocular pressure (IOP) >21 mm Hg or reduced <20% below baseline on 2 consecutive follow-up visits after 3 months, IOP ≤5 mm Hg on 2 consecutive follow-up visits, reoperation for glaucoma or a complication, or loss of light perception.

Results:
Forty-three eyes of 36 children were studied, including 26 eyes in the early-onset group and 17 eyes in the late-onset group. The early-onset group more frequently presented with buphthalmos, corneal edema, and Haab striae, while late-onset group had higher baseline IOP, larger cup-to-disc ratio, and longer axial length. The most commonly performed primary surgery was trabeculotomy (50%) in early-onset group and tube shunt implantation (71%) in late-onset group. The cumulative probability of failure after 5 years follow-up was 50.6% in early-onset group and 50.9% in the late-onset group (P=0.56). Postoperative complications occurred in 3 eyes (12%) in early-onset group and 11 eyes (65%) in late-onset group (P<0.001).

Conclusions:
Early and late-onset SWS glaucoma may represent 2 entities with different pathogenetic mechanisms, clinical presentations, primary surgical choices, and outcomes, though this needs corroboration in future studies.
Venlafaxine-Associated Rhabdomyolysis
Authors: Ren Jieru , Wang Ying , Nie Jing , Sun Lei , Wu Huina , Li Yamei , Wu Jiyong 
Published: March 2024

Abstract

Purpose
This systematic review aimed to investigate the clinical manifestations and characteristics of venlafaxine-associated rhabdomyolysis.

Methods
A systematic search was conducted in PubMed, Elsevier, Science Direct, Embase, Springer Link, Wiley Online Library, CNKI, and Wanfang databases from the date of database inception to January 2023. Previously reported cases of venlafaxine-associated rhabdomyolysis were identified, and relevant data from these cases were collected for descriptive statistical analysis. Cases that met the inclusion criteria were evaluated to determine the correlation between adverse reactions and venlafaxine.

Results
A total of 12 patients with venlafaxine-associated rhabdomyolysis were included. None of these patients had a history of muscle pain or discomfort. Of the 12 patients, 5 patients received venlafaxine at doses of ≤225 mg/d, whereas the remaining 7 patients received doses exceeding 225 mg/d. The main clinical symptoms included myalgia, muscle weakness, and renal injury. All 12 patients discontinued venlafaxine and received symptomatic care.

Conclusions
Venlafaxine, used either as a monotherapy or in combination with other drugs, may be associated with rhabdomyolysis. Creatine kinase levels may normalize or significantly decrease after discontinuation of venlafaxine and symptomatic treatment.
Lichen Sclerosus et Atrophicus
Authors: Nellis Julia , Gardner Kenzie 
Published: March 2024

ABSTRACT
Lichen sclerosus (LS) et atrophicus et atrophicus, commonly referred to as LS, is a relatively uncommon chronic inflammatory condition that typically affects the skin of the vulvar and perianal regions but can involve extragenital areas. This review will focus primarily on vulvar LS. Although LS can affect men and prepubescent patients, LS has a much higher incidence in women over the age of 30 years. When correctly diagnosed and treated in its earlier stages, LS, although still chronic, is manageable with the appropriate protocol. When left untreated or poorly managed, LS can progress to its later “atrophic” stages and cause severe lichenification, atrophy, and destructive scarring, resulting in the loss of normal anatomic landmarks and function of the genitals. In addition, both men and women with genital LS have an increased risk of developing squamous cell carcinoma in the affected skin. In women, 65% of genital squamous cell carcinomas arise from a preexisting lesion from LS. This can negatively affect a patient's sleep and physical, mental, and social/emotional health. Increased awareness of the presentation and symptoms, in both providers and patients, of LS et atrophicus encourages earlier treatment and management while preventing long-term, irreversible physical, mental, and emotional damage.
Tumid Lupus Case Report
Authors: Valentine Elizabeth , Wallace Katie 
Published: March 2024

ABSTRACT
Cutaneous lupus erythematosus (CLE) can present with a wide variety of dermatologic manifestations and is broken down into acute, subacute, and chronic subtypes. Tumid lupus, a variant of CLE, is rarely associated with systemic lupus erythematosus. Lesions of CLE and tumid lupus can mimic multiple other dermatologic conditions. We present a case of a patient with tumid lupus who was initially treated for erythema migrans and systemic symptoms suspected to represent Lyme disease. This article is intended for nurse practitioners, nurses, and other clinicians practicing in dermatology, primary care, urgent care, and emergency medicine settings in the care of patients presenting with annular skin lesions.
Heterotopic Ossification Is Associated with Painful Neuromas in Transtibial Amputees Undergoing Surgical Treatment of Symptomatic Neuromas
Authors: Raasveld Floris V. , Liu Wen-Chih , Renthal William R. , Fleming Mark E. , Valerio Ian L. , Eberlin Kyle R. 
Published: March 2024

Background:
A relationship between nerve and osseous regeneration has been described. During the surgical treatment of symptomatic neuroma in transtibial amputees, the authors have found that heterotopic ossification (HO) depicted on preoperative radiographs appeared to be associated with the location of symptomatic neuromas in both the peroneal and tibial nerve distributions.

Methods:
Data were collected for transtibial amputees who underwent surgical management of symptomatic neuroma and were prospectively enrolled from 2018 through 2023. Preoperative radiographs were assessed for the presence of HO located at the distal fibula and tibia. The presence of a peroneal or tibial neuroma was based on findings contained within the operative reports. Pain levels were measured on a numeric rating scale (0 to 10).

Results:
Sixty-five limbs of 62 amputees were included. Peroneal neuroma and presence of fibular HO (P = 0.001) and tibial neuroma and presence of tibial HO (P = 0.038) demonstrated an association. The odds of having a symptomatic peroneal neuroma with fibular HO present were greater than the odds of a symptomatic peroneal neuroma when fibular HO was absent (OR, 9.3 [95% CI, 1.9 to −45.6]; P = 0.006). Preoperative pain scores were significantly higher for all patients with HO (P < 0.001), those with fibular HO (P < 0.001), and those with tibial HO (P < 0.001), compared with patients without HO.

Conclusions:
In patients with symptomatic neuromas, preoperative pain was worse when HO was present in the transtibial amputee’s residual limb. Further research on the neuroma–HO complex in symptomatic amputees is required.

CLINICAL QUESTION/LEVEL OF EVIDENCE:
Risk, III.
Reliability and validity of the Turkish version of the Prosthesis Embodiment Scale for Lower Limb Amputees
Authors: Demirdel Senem , Demirdel Ertuğrul , Söyler Osman , Akyol Mesut 
Published: March 2024

Background:
Prosthetic embodiment is the perception of the prosthesis as a part of the body, and it is important for acceptance and adequate and effective use of the prosthesis.

Objective:
The aim of this study was to investigate the validity and reliability of the Turkish version of the Prosthesis Embodiment Scale for Lower Limb Amputees.

Methods:
This cross-sectional study included a total of 88 lower limb amputees. Internal consistency was evaluated using Cronbach α coefficient. The test-retest reliability of the scale, which was reapplied after 7–10 d, was evaluated using intraclass correlation coefficient. Principal component analysis with Varimax rotation was used to analyze the factor structure. Spearman correlation coefficient with Trinity Amputation and Prosthesis Experience Scale subscales was calculated for concurrent validity.

Results:
The mean age of the participants was 45.13 ± 15.05 years, and 76.1% were male. Internal consistency (Cronbach α = 0.905) and test-retest reliability (intraclass correlation coefficient = 0.822) were high. 76.1% of the total variance could be explained by the 3 dimensions. Significant correlation was found with the Trinity Amputation and Prosthesis Experience Scale subscales (r = 0.542 for psychosocial adjustment subscale, r = −0.452 for activity restriction subscale, r = 0.490 for prosthesis satisfaction subscale, p < 0.001).

Conclusions:
The results of this study showed that the Turkish version of the Prosthesis Embodiment Scale for Lower Limb Amputees is a valid and reliable tool that can be used to evaluate prosthetic rehabilitation outcomes.
Use of standardized outcome measures for people with lower-limb amputation: A survey of prosthetic practitioners in Canada
Authors: Pousett Brittany Mae , Kok Bram P. W. , Morgan Sara J. , Hafner Brian J. 
Published: March 2024

Background:
Outcome measures (OMs) are useful tools; however, clinicians may find implementing them into clinical practice challenging.

Objectives:
To characterize Canadian prosthetists’ use of OMs for people with lower-limb amputation, including motivations for use, comfort selecting OMs, resources available for administration, and barriers to implementation.

Methods:
A cross-sectional study was conducted between March and July 2021. Orthotics Prosthetics Canada sent Canadian prosthetists an invitation to take the online survey.

Results:
Forty-nine Certified Prosthetists completed the survey. Only 16% of participants reported that they were expected to use OMs. Participants reported being more comfortable administering performance-based OMs than self-report surveys. More than two-thirds of participants agreed that OMs “can be administered with knowledge they have” and are “within their scope of practice.” However, less than 25% agreed that OMs are “administered in a standardized way in the profession,” and less than 40% indicated they are “easy to make part of my routine.” Participants reported they generally have time and space to do OMs, but there was no agreed-on reason to use them.

Conclusions:
Use of OMs among Canadian prosthetists seems to be low relative to prosthetists in the United States. Education, financial incentives, or changes to professional expectations are likely needed to increase routine OM use. Efforts to improve the standardization of OM administration and ease the incorporation of OMs into routine practice may also increase use. Canadian prosthetists may elevate their standards of clinical practice and better understand the impact of prosthetic treatments on their patients by more routinely using OMs.
Cumulative exposure to depressive symptoms and all-cause mortality among adults with HIV in Kenya, Nigeria, Tanzania, and Uganda
Authors: Kemp Christopher G. , Pence Brian W. , Velloza Jennifer , Concepcion Tessa , Moitra Modhurima , Iroezindu Michael , Bahemana Emmanuel , Kibuuka Hannah , Semwogerere Michael , Owuoth John , Maswai Jonah , Langat Rither , Esber Allahna L. , Dear Nicole F. , Parikh Ajay , Crowell Trevor A. , Ake Julie A. , Polyak Christina S. , Collins Pamela Y. ,   the AFRICOS Study Group
Published: March 2024

Objective:
We estimated the effects of cumulative exposure to depressive symptoms on risk of all-cause mortality among people with HIV (PWH) in four African countries.

Design:
An analysis of prospective cohort data.

Methods:
The African Cohort Study (AFRICOS) is a prospective cohort of people receiving care at twelve clinics in Kenya, Nigeria, Tanzania, and Uganda. Every 6 months from January 2013 to May 2020, participants underwent laboratory monitoring, structured surveys, and assessment of depressive symptom severity using the Center for Epidemiologic Studies Depression Scale (CES-D). All-cause mortality was the outcome of interest. The predictor of interest was a time-updated measure of the percentage of days lived with depression (PDD). Marginal structural Cox proportional hazards regression models were used, adjusting for potential confounders including time-varying alcohol use, drug use, and viral load.

Results:
Among 2520 enrolled participants, 1479 (59%) were women and the median age was 38 (interquartile range [IQR]: 32–46). At enrollment, 1438 (57%) were virally suppressed (<200 copies/ml) and 457 (18%) had CES-D at least 16, indicating possible depression. Across 9093 observed person-years, the median PDD was 0.7% (IQR: 0–5.9%) with 0.8 deaths per 100 person-years. Leading causes of death included cancer (18% of deaths) and accidents (14%). Models suggested that each 25% absolute increase in PDD was associated with a 69% increase in the risk of all-cause mortality (hazard ratio: 1.69; 95% confidence interval: 1.18–2.43).

Conclusion:
Cumulative exposure to depressive symptoms was substantially associated with the risk of mortality in this cohort of PWH in Africa.
Graphene Multiplexed Sensor for Point-of-Need Viral Wastewater-Based Epidemiology
Authors: Geiwitz Michael , Page Owen Rivers , Marello Tio , Kumar Narendra , Hummel Stephen , Belosevich Vsevolod , Ma Qiong , van Opijnen Tim , Batten Bruce , Meyer Michelle M. , Burch Kenneth S. 
Published: March 2024

AbstractWastewater-based epidemiology (WBE) can help mitigate the spread of respiratory infections through the early detection of viruses, pathogens, and other biomarkers in human waste. The need for sample collection, shipping, and testing facilities drives up the cost of WBE and hinders its use for rapid detection and isolation in environments with small populations and in low-resource settings. Given the ubiquitousness and regular outbreaks of respiratory syncytial virus, SARS-CoV-2 and various influenza strains, there is a rising need for a low-cost and easy-to-use biosensing platform to detect these viruses locally before outbreaks can occur and monitor their progression. To this end, we have developed an easy-to-use, cost-effective, multiplexed platform able to detect viral loads in wastewater with several orders of magnitude lower limit of detection than mass spectrometry. This is enabled by wafer scale production and aptamers pre-attached with linker molecules, producing forty-four chips at once. Each chip can simultaneously detect four target analytes using twenty transistors segregated into four sets of five for each analyte to allow for immediate statistical analysis. We show our platform’s ability to rapidly detect three virus proteins (SARS-CoV-2, RSV, and Influenza A) and a population normalization molecule (caffeine) in wastewater. Going forward, turning these devices into hand-held systems would enable waste-water epidemiology in low-resource settings and be instrumental for rapid, local outbreak prevention.
LarvaTagger: Manual and automatic tagging ofDrosophilalarval behaviour
Authors: Laurent François , Blanc Alexandre , May Lilly , Gándara Lautaro , Cocanougher Benjamin T. , Jones Benjamin M.W. , Hague Peter , Barré Chloé , Vestergaard Christian L. , Crocker Justin , Zlatic Marta , Jovanic Tihana , Masson Jean-Baptiste 
Published: March 2024

MotivationAs more behavioural assays are carried out in large-scale experiments onDrosophilalarvae, the definitions of the archetypal actions of a larva are regularly refined. In addition, video recording and tracking technologies constantly evolve. Consequently, automatic tagging tools forDrosophilalarval behaviour must be retrained to learn new representations from new data. However, existing tools cannot transfer knowledge from large amounts of previously accumulated data. We introduce LarvaTagger, a piece of software that combines a pre-trained deep neural network, providing a continuous latent representation of larva actions for stereotypical behaviour identification, with a graphical user interface to manually tag the behaviour and train new automatic taggers with the updated ground truth.ResultsWe reproduced results from an automatic tagger with high accuracy, and we demonstrated that pre-training on large databases accelerates the training of a new tagger, achieving similar prediction accuracy using less data.AvailabilityAll the code is free and open source. Docker images are also available. Seegit-lab.pasteur.fr/nyx/LarvaTagger.jl.
mLiftOver: Harmonizing Data Across Infinium DNA Methylation Platforms
Authors: Chen Brian H. , Zhou Wanding 
Published: March 2024

SummaryInfinium DNA methylation BeadChips are widely used for genome-wide DNA methylation profiling at the population scale. Recent updates to probe content and naming conventions in the EPIC version 2 (EPICv2) arrays have complicated integrating new data with previous Infinium array platforms, such as the EPIC and the HumanMethylation450 (HM450) BeadChip. We presentmLiftOver, a user-friendly tool that transfers probe ID, methylation level, and signal intensity data across different Infinium platforms. It manages probe replicates, missing data imputation, and platform-specific bias for accurate data conversion. We validated the tool by applying HM450-based cancer classifiers to EPICv2 cancer data, achieving high accuracy. Additionally, we successfully integrated EPICv2 healthy tissue data with legacy HM450 data for tissue identity analysis and produced consistent copy number profiles in cancer cells.Availability and implementationmLiftOver is implemented R and available in the Bioconductor package SeSAMe (version 3.21.13+):https://bioconductor.org/packages/release/bioc/html/sesame.htmlAnalysis of EPIC and EPICv2 platform-specific bias and high-confidence mapping is available athttps://github.com/zhou-lab/InfiniumAnnotationV1/blob/main/Anno/EPICv2/EPICv2ToEPIC_conversion.tsv.gzThe source code is available athttps://github.com/zwdzwd/sesame/blob/devel/R/mLiftOver.Runder the MIT license.