bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antibacterial wound dressing with cross‐linked electrospun surface from reduced graphene oxide doped polyvinyl alcohol/sodium caseinate blends
Authors: Samatya Yilmaz Sema , Aytac Ayse 
Published: April 2024

AbstractIn this study, a new biomaterial with polyvinyl alcohol (PVA)/sodium caseinate (SodCa)/reduced graphene oxide (rGO) structure was developed. Antibacterial effective nanofibers were successfully produced by electrospinning method from 1%, 3%, 5%, and 7% rGO added PVA/SodCa (60:40, w:w) solution mixtures prepared for use as modern wound dressings. To create a usage area, especially in exuding wounds, hydrophilic PVA/SodCa/rGO electrospun mats were cross‐linked by dipping them in a glutaraldehyde (GLA) bath. The surface micrographs of all nanofibers were homogeneous and smooth. rGO‐doped biomaterials were obtained as thin nanofibers in the range of 301–348 nm. Nanofibers, which were completely soluble in water, after cross‐linking preserved their existence in the range of 87%–81% at the end of the 24th hour in distilled water. It was reported that these biomaterials that persist in an aqueous environment show swelling behavior in the range of 275%–608%. The porosity of uncross‐linked pure PVA/SodCa nanofibers increased by 46.75% after cross‐linking. Moreover, the tensile strength of cross‐linked PVA/SodCa electrospun mats increased in the presence of rGO. Provided that wound dressing is done every 24 h with 3% rGO‐doped PVA/SodCa nanofiber and provided that wound dressing is done every 48 h with 5% rGO‐doped PVA/SodCa nanofiber showed antibacterial activity against S. aureus as 99.38% and 99.55%, respectively.
Computer‐aided experimental studies for adaptive beamforming algorithms and array processing in engineering education
Authors: Salas‐Natera Miguel A. , Zorkun Aral E. , Rodríguez‐Osorio Ramón M. 
Published: April 2024

AbstractSmart antenna and digital antenna systems are considered as a crucial technology for current and future communication systems supporting 5G/6G and nonterrestrial‐networks communications. Based on the information of the received signal/s, smart antenna systems toward the radiation pattern to the desired direction/s. This technique is known as adaptive beamforming. The theories and the applications of adaptive beamforming are taught in engineering educational courses. This paper proposes a set of real‐time interactive experiments for adaptive beamforming algorithms in antenna array processing subject. The proposed experiments can be performed with the computer‐aided experimental studies tool prepared in the MATLAB® environment. The users can easily make comparisons and can perform trade‐offs between different types of adaptive beamforming algorithms, scenarios, and antenna architecture. This is used as a teaching tool for a graduate course on adaptive beamforming algorithms.
Psychological empowerment and exercising: The relationships between exercising, self‐stereotyping, agency, autonomy and physical self‐efficacy in non‐Western women
Authors: Mosanya Magdalena , Kassie Seada 
Published: April 2024

AbstractDespite recent efforts towards equality, there are still gender disparities in Middle Eastern societies, where women are often discouraged from viewing themselves as autonomous, competent and self‐determining individuals due to the internalization of traditional gender norms. Research on women's empowerment in multicultural and non‐Western societies is scarce. In the absence of other interventions, exercising has been effective in increasing women's psychological and physical strength. The present study focused on women (N = 250) living in a non‐Western and multicultural environment, aiming to assess whether (a) self‐stereotyping negatively correlates with factors of empowerment (operationalized as a sense of autonomy, agency and self‐efficacy) and exercising, (b) exercising is positively associated with factors of empowerment and (c) if exercising would mediate the hypothesized relationship of self‐stereotyping on empowerment. Secondly, the study also qualitatively explored the subjectively reported exercising motives and outcomes. The results of quantitative analyses confirmed that self‐stereotyping was negatively correlated with autonomy and agency, but not with physical self‐efficacy. Exercising was positively correlated with all the factors of empowerment and negatively with self‐stereotyping. The structural equation modelling supported the intermediary role of exercising in the associations between self‐stereotyping and autonomy and agency. The qualitative analysis revealed that although the participants principally exercised for health‐related motives, the reported outcome was primarily reflective of experiences of empowerment. The findings could be used to inform current policies and interventions geared towards women to support and promote their physical and psychological well‐being.
Synthesis and Inhibitor Effect Novel Alkoxymethyl Derivatives of Dihetero Cycloalkanes on Carbonic Anhydrase and Acetylcholinesterase
Authors: Farzaliyev Vagif , Ertürk Adem , Abbasova Malahat , Nabiyev Oruj , Demir Yeliz , Kızıltaş Hatice , Sujayev Afsun , Gülçin İlhami 
Published: April 2024

Abstract1,3‐Diheterocycloalkanes derivatives are important starting materials in fine organic synthesis. These compounds can be widely used in various fields such as industry, medicine, biotechnology and chemical technology. The paper is focused on synthesis and study of alkoxymethyl derivatives of diheterocycloalkanes (M1–M15) and inhibition effect on carbonic anhydrase and acetylcholinesterase. The structures of compounds were confirmed by 1H and 13C NMR spectroscopy. Also, in this study alkoxymethyl derivatives of diheterocycloalkanes were assessed for their influence on various metabolic enzymes, including acetylcholinesterase (AChE) and human carbonic anhydrase isoenzymes (hCA I and hCA II). The results demonstrated that all these compounds exhibited potent inhibitory effects on all the target enzymes, surpassing the standard inhibitors, as evidenced by their IC50 and Ki values. The Ki values for the compounds concerning AChE, hCA I, and hCA II enzymes were in the ranges of 1.02±0.17–8.38±1.02, 15.30±3.15–58.14±5.17 and 24.05±3.70–312.94±27.24 nM, respectively.
The impact of unilateral pulmonary artery stenosis on right ventricular to pulmonary arterial coupling in patients with transposition of the great arteries
Authors: Joosen Renée S. , Voskuil Michiel , Krings Gregor J. , Handoko M. Louis , Dickinson Michael G. , van de Veerdonk Marielle C. , Breur Johannes M. P. J. 
Published: April 2024

AbstractBackgroundUnilateral pulmonary artery (PA) stenosis is common in the transposition of the great arteries (TGA) after arterial switch operation (ASO) but the effects on the right ventricle (RV) remain unclear.AimsTo assess the effects of unilateral PA stenosis on RV afterload and function in pediatric patients with TGA‐ASO.MethodsIn this retrospective study, eight TGA patients with unilateral PA stenosis underwent heart catheterization and cardiac magnetic resonance (CMR) imaging. RV pressures, RV afterload (arterial elastance [Ea]), PA compliance, RV contractility (end‐systolic elastance [Ees]), RV‐to‐PA (RV‐PA) coupling (Ees/Ea), and RV diastolic stiffness (end‐diastolic elastance [Eed]) were analyzed and compared to normal values from the literature.ResultsIn all TGA patients (mean age 12 ± 3 years), RV afterload (Ea) and RV pressures were increased whereas PA compliance was reduced. RV contractility (Ees) was decreased resulting in RV‐PA uncoupling. RV diastolic stiffness (Eed) was increased. CMR‐derived RV volumes, mass, and ejection fraction were preserved.ConclusionUnilateral PA stenosis results in an increased RV afterload in TGA patients after ASO. RV remodeling and function remain within normal limits when analyzed by CMR but RV pressure–volume loop analysis shows impaired RV diastolic stiffness and RV contractility leading to RV‐PA uncoupling.
Bullous striae distensae in a nephrotic syndrome patient: First case report from the Middle East of a rare presentation and review of the literature
Authors: Alrefaie Sumayyah I. , Aljoudi Sarah B. , Nukaly Houriah Y. , ALHawasawi Waseem K. , Hariri Jehad O. 
Published: April 2024

AbstractStriae distensae is a common cutaneous phenomenon that begins as reddish linear atrophic plaques (striae rubra) that over time progress to silvery‐white coloration (stria alba). Striae distensae in rare occasions becomes edematous, ulcerative, emphysematous, or urticated. Bullous striae distensae is a sequela of conditions causing interstitial edema along with systemic glucocorticoids use. To our knowledge, only eight cases of bullous striae distensae have been reported in the literature. Herein, we report a 17‐year‐old female, known case of nephrotic syndrome, presented to our clinic with abdominal fluid‐fill cutaneous lesions only for 5 days. She had used systemic glucocorticoids for more than a decade before she was labeled as steroid resistant nephrotic syndrome. Cushingoid body habitus were observed during physical examination, in addition to translucent bullae overlying her previously known stretch marks. Punch biopsy of the lesions revealed dermal edema with thinned collagen bundles. Based on these clinicopathological findings, a diagnosis of bullous striae distensae was made. Awareness of this rare complication and unusual clinical presentation is fundamental to avoid unnecessary and excessive interventions whether investigatory or therapeutic in order to provide appropriate management of the underlying condition.
A patient with a rare co‐occurrence of papillary and follicular thyroid carcinomas
Authors: Kamalumpundi Vijayvardhan , Meyers Erin , Torfah Maisoon , de Gusmão Correia Marcelo Lima 
Published: April 2024

Key Clinical MessageThe occurrence of papillary and follicular thyroid carcinoma as a collision tumor is rare. We report on a case of a collision tumor consisting of papillary and follicular thyroid carcinoma treated successfully with surgery and radioiodine ablation.
Prospects in Sustainable Hydrosilylation by Biphase Catalysis
Authors: Goncharova Irina K. , Beletskaya Irina P. , Arzumanyan Ashot V. 
Published: April 2024

AbstractThis concept addresses the main economic, environmental, scientific and technological issues associated with the use of homogeneous Pt‐catalysts in the important industrial hydrosilylation process. The development of biphase catalysis is proposed as the most promising approach. One solution we suggest is the use of ethylene glycol (EG) as a medium in biphase catalysis. We have previously shown that EG in Pt‐catalyzed hydrosilylation serves not only as a medium but also as a mild reducing agent of Pt‐ions to Pt0, as well as an effective ligand for the preparation of mononuclear Pt01‐complexes. These zero valent platinum complexes are single‐atom catalysts (SAC) and have high activity in hydrosilylation, stability during storage and the ability to be recycled multiple times (~40 times). This option of using an atomic catalyst allows us to combine the advantages of homogeneous and heterogeneous catalysts.
A simple form could prevent authorship issues in Cochrane manuscripts: A cohort study
Authors: Fonnes Siv , Andresen Kristoffer , Öberg Stina , Baker Jason Joe , Rosenberg Jacob 
Published: April 2024

AbstractAimWe aimed to investigate authorship issues after the implementation of an authorship declaration form in a Cochrane Review Group.MethodsThe Cochrane Colorectal Group uses an authorship declaration form that consists of three parts: (1) manuscript information, (2) documentation for roles according to the four authorship criteria of the International Committee of Medical Journal Editors (ICMJE), and (3) identification information of individual authors and signed approval. The manuscripts' contact authors were responsible for collecting the forms from all coauthors. This observational cohort study reports on all authorship issues in authorship declaration forms collected from February 2020 to December 2023.ResultsWe received 276/277 authorship declaration forms or replies from authors (response rate 99.6%) from 44 manuscripts, including 52% protocols and 48% reviews. There were authorship issues present in 14/44 (32%) of the manuscripts, and the most common issue was that not all authors fulfilled all four ICMJE authorship criteria. Six gift authors were removed from by‐lines. Issues in nine of the 14 manuscripts were resolved by the author group when informing them about the ICMJE authorship criteria and guidance from the Committee on Publication Ethics (COPE). The issues in the remaining five manuscripts were unresolved since the manuscripts were transferred or rejected, thus, ceased to be developed by the Cochrane Colorectal Group.ConclusionAuthorship issues were raised in almost one‐third of manuscripts. Most issues were resolved and six gift authorships were prevented. The awareness of authorship criteria is sharpened when all authors are individually asked to fill out and sign a form. This could help decrease the rate of unethical authorships in Cochrane publications and contribute to more ethical and robust evidence production.
A novel improvement strategy and a comprehensive mechanism insight for α‐MnO2 energy storage in rechargeable aqueous zinc‐ion batteries
Authors: Xiankai Fan , Kaixiong Xiang , Wei Zhou , Weina Deng , Hai Zhu , Liang Chen , Han Chen 
Published: April 2024

AbstractAqueous zinc‐ion batteries have been regarded as the most potential candidate to substitute lithium‐ion batteries. However, many serious challenges such as suppressing zinc dendrite growth and undesirable reactions, and achieving fully accepted mechanism also have not been solved. Herein, the commensal composite microspheres with α‐MnO2 nano‐wires and carbon nanotubes were achieved and could effectively suppress ZnSO4·3Zn(OH)2·nH2O rampant crystallization. The electrode assembled with the microspheres delivered a high initial capacity at a current density of 0.05 A g−1 and maintained a significantly prominent capacity retention of 88% over 2500 cycles. Furthermore, a novel energy‐storage mechanism, in which multivalent manganese oxides play a synergistic effect, was comprehensively investigated by the quantitative and qualitative analysis for ZnSO4·3Zn(OH)2·nH2O. The capacity contribution of multivalent manganese oxides and the crystal structure dissection in the transformed processes were completely identified. Therefore, our research could provide a novel strategy for designing improved electrode structure and a comprehensive understanding of the energy storage mechanism of α‐MnO2 cathodes.
Engineered Nanomaterials for Tumor Immune Microenvironment Modulation in Cancer Immunotherapy
Authors: Xing Hao , Li Xiaomin 
Published: April 2024

AbstractTumor immunotherapy, represented by immune checkpoint blocking and chimeric antigen receptor (CAR) T cell therapy, has achieved promising results in clinical applications. However, it faces challenges that hinder its further development, such as limited response rates and poor tumor permeability. The efficiency of tumor immunotherapy is also closely linked to the structure and function of the immune microenvironment where the tumor resides. Recently, nanoparticle‐based tumor immune microenvironment (TIME) modulation strategies have attracted a great deal of attention in cancer immunotherapy. This is primarily due to the distinctive physical characteristics of nanoparticles, which enable them to effectively infiltrate the TIME and selectively modulate its key constituents. This paper reviews recent advances in nanoparticle engineering to improve anti‐cancer immunotherapy. Emerging nanoparticle‐based approaches for modulating immune cells, tumor stroma, cytokines and immune checkpoints are discussed, aiming to overcome current challenges in the clinic. In addition, integrating immunotherapy with various treatment modalities such as chemotherapy and photodynamic therapy can be facilitated through the utilization of nanoparticles, thereby enhancing the efficacy of cancer treatment. The future challenges and opportunities of using nanomaterials to reeducate the suppressive immune microenvironment of tumors are also discussed, with the aim of anticipating further advancements in this growing field.
Improving attitudes toward brands with global consumer culture positioning: The triggering role of emotions
Authors: Cai Yuanyuan , Wu Yi , He Jiaxun , Liu Yongxin 
Published: April 2024

AbstractThis research examines how incidentally evoked approach‐oriented (vs. avoidance‐oriented) emotions help improve consumer attitudes toward brands with global consumer culture positioning (GCCP). Moreover, we demonstrate that promotion‐focused brand associations that are uniquely linked with GCCP messages mediate this effect, while this effect is eliminated when consumers are aware of the potential influence of their emotions on judgment. We conducted four experiments to examine and clarify the above effects. The findings contribute theoretically by introducing emotions as a novel antecedent to consumers' GCCP preferences. Practically, this research provides actionable guidelines for international marketers in effectively implementing GCCP strategies.
Bifunctional Metal‐Organic Nanoballs Featuring Lewis Acidic and Basic Sites as a New Platform for One‐Pot Tandem Catalysis
Authors: Verma Gaurav , Kumar Sanjay , Slaughter Elliott R. , Vardhan Harsh , Alshahrani Thamraa M. , Niu Zheng , Gao Wen‐Yang , Wojtas Lukasz , Chen Yu‐Sheng , Ma Shengqian 
Published: April 2024

AbstractThe design and synthesis of polyhedra using coordination‐driven self‐assembly has been an intriguing research area for synthetic chemists. Metal‐organic polyhedra are a class of intricate molecular architectures that have garnered significant attention in the literature due to their diverse structures and potential applications. Hereby, we report Cu‐MOP, a bifunctional metal‐organic cuboctahedra built using 2,6‐dimethylpyridine‐3,5‐dicarboxylic acid and copper acetate at room temperature. The presence of both Lewis basic pyridine groups and Lewis acidic copper sites imparts catalytic activity to Cu‐MOP for the tandem one‐pot deacetalization‐Knoevenagel/Henry reactions. The effect of solvent system and time duration on the yields of the reactions was studied, and the results illustrate the promising potential of these metal‐organic cuboctahedra, also known as nanoballs for applications in catalysis.
Substituent Effects in the Cationic Green Fluorescent Protein Chromophore: Ultrafast Excited‐State Proton Transfer or Twisting?
Authors: Liu Jiawei , Chen Cheng , Sokolov Anatolii I. , Baranov Mikhail S. , Fang Chong 
Published: April 2024

AbstractUnderstanding the structure‐function relationships of the green fluorescent protein (GFP) chromophore is important in rationally developing new molecular tools for biological imaging and beyond. Herein, we systematically modified the GFP chromophore structure with electron‐withdrawing and ‐donating groups (EWGs and EDGs) to investigate the substituent effects on the excited‐state proton transfer (ESPT) and twisting dynamics of the cationic chromophore in solution. With key insights gained from femtosecond transient absorption and stimulated Raman spectroscopy, we reveal that the EWG substitution by –F increases photoacidity in an additive manner and leads to an ultrafast barrierless ESPT by difluorination, while the EDG substitution by –OCH3 also results in ultrafast ESPT despite the weak photoacidity as estimated by the Förster equation. We ascribe the unusually fast kinetics in methoxylated derivatives to the occurrence of a pre‐existing chromophore‐solvent complex that sets up the acceptor site for ESPT. Furthermore, the kinetic competition between ESPT and twisting pathways is crucial for the observation of ESPT in action, particularly for molecules undergoing efficient nonradiative decay in the excited state through torsional motions. Such flexible and highly engineerable molecules can enable more versatile photoswitches and sensors.
Purification of SRSF1 from E. coli for Biophysical and Biochemical Assays
Authors: Zhang Zihan , Zhang Jun 
Published: April 2024

AbstractThe Ser/Arg‐rich splicing factors (SR proteins) constitute a crucial protein family in alternative splicing, comprising twelve members characterized by unique repetitive Arg‐Ser dipeptide sequences (RS) and one to two RNA‐recognition motifs (RRM). The RS regions of SR proteins undergo variable phosphorylation, resulting in unphosphorylated, partially phosphorylated, or hyper‐phosphorylated states based on functional requirements. Despite the identification of the SR protein family over 30 years ago, the purification of native SR proteins in soluble form at large quantities has presented challenges due to their low solubility. This protocol delineates a method for acquiring soluble, full‐length, unphosphorylated, hypo‐ and hyper‐phosphorylated SRSF1, a prototypical SR family member. Notably, this protocol facilitates the purification of SRSF1 in ample quantities suitable for NMR, as well as various biophysical and biochemical studies. The methodologies and principles outlined herein are expected to extend beyond SRSF1 protein production and can be adapted for purifying other SR protein family members or SR‐related proteins, such as snRNP70 and U2AF‐35. Given the involvement of these proteins in numerous essential biological processes, this protocol will prove beneficial to researchers in related fields. © 2024 The Authors. Current Protocols published by Wiley Periodicals LLC.Basic Protocol 1: Purification of SRSF1 from E. coliSupport Protocol: Purification of ULP1Basic Protocol 2: Purification of hypo‐phosphorylated SRSF1 from E. coliBasic Protocol 3: Purification of hyper‐phosphorylated SRSF1 from E. coli
Development of an implicit electromagnetic capability for a hybrid gyrokinetic ion‐fluid electron model
Authors: Dorf Mikhail , Dorr Milo , Ghosh Debojyoti 
Published: April 2024

AbstractWe report on the development and implementation of a hybrid kinetic ion–fluid electron model for electromagnetic COGENT simulations of edge plasmas. COGENT is a finite‐volume gyrokinetic code that employs a locally field‐aligned coordinate system combined with a mapped multi‐block grid technology to handle strongly anisotropic edge plasma turbulence. The simulation model involves the long‐wavelength limit of the ion gyrokinetic equation coupled to the vorticity and Ohm's law equations for the electromagnetic field perturbations. In order to handle the fast Alfvén wave time scales, an implicit‐explicit time integration approach with a physics‐based preconditioner is used. The model is successfully applied to the simulations of ion‐scale resistive‐drift ballooning turbulence in a toroidal annulus geometry. Substantial speed‐up over a fully explicit time integration approach is observed.