bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reversible Protonated Electrolyte Additive Enabling Dendrites‐Free Zn Metal Anode with High Depth of Discharge
Authors: Wang Yuao , Wang Tiantian , Mao Yiyang , Li Zhuo , Yu Huiying , Su Mingyu , Ye Ke , Cao Dianxue , Zhu Kai 
Published: April 2024

AbstractAqueous zinc ion batteries (AZIBs) have stimulated extensive attention due to their environmental friendliness and low cost. Unfortunately, the inevitable dendrite growth and corrosion on the zinc (Zn) anode severely hinder the practical application of AZIBs. Herein, an amino acid containing an imidazole group is introduced as an effective additive to address these issues. The dynamic conversion of amino acid and protonated amino acid creates a pH buffer function that regulates solution pH in real time, inhibits hydrogen evolution reaction (HER), and eliminates notorious by‐products. In addition, the protonated amino acid is preferentially adsorbed on the Zn anode, preventing contact of the active water with the Zn surface and promoting homogeneous Zn deposition. Thus, the amino acid‐based electrolyte promotes dendrite free plating/stripping with a Coulombic efficiency up to 99.67% and cycle lifetime of 2600 h. In particular, a depth of discharge of up to 87% can be achieved with an ultra‐high areal capacity of 24 mAh cm−2. The developed Zn||CVO full cell also exhibits better electrochemical performance than that without additives. This work provides an effective and convenient approach for safe and efficient Zn‐ion batteries.
Probing Energy‐Funneling Kinetics in Nanocrystal Sublattices for Superior X‐Ray Imaging
Authors: Wu Qinxia , Xu Xinqi , Li Xiaokun , Jiang Hao , Qin Xian , Hong Zhongzhu , Chen Xiaofeng , Yang Zhijian , Ou Xiangyu , Xie Lili , He Yu , Han Sanyang , Chen Qiushui , Yang Huanghao 
Published: April 2024

AbstractLong‐lasting radioluminescence scintillators have recently attracted substantial attention from both research and industrial communities, primarily due to their distinctive capabilities of converting and storing X‐ray energy. However, determination of energy‐conversion kinetics in these nanocrystals remains unexplored. Here we present a strategy to probe and unveil energy‐funneling kinetics in NaLuF4:Mn2+/Gd3+ nanocrystal sublattices through Gd3+‐driven microenvironment engineering and Mn2+‐mediated radioluminescence profiling. Our photophysical studies reveal effective control of energy‐funneling kinetics and demonstrate the tunability of electron trap depth ranging from 0.66 to 0.96 eV, with the corresponding trap density varying between 2.38×105 and 1.34×107 cm−3. This enables controlled release of captured electrons over durations spanning from seconds to 30 days. It allows tailorable emission wavelength within the range of 520–580 nm and fine‐tuning of thermally‐stimulated temperature between 313–403 K. We further utilize these scintillators to fabricate high‐density, large‐area scintillation screens that exhibit a 6‐fold improvement in X‐ray sensitivity, 22 lp/mm high‐resolution X‐ray imaging, and a 30‐day‐long optical memory. This enables high‐contrast imaging of injured mice through fast thermally‐stimulated radioluminescence readout. These findings offer new insights into the correlation of radioluminescence dynamics with energy‐funneling kinetics, thereby contributing to the advancement of high‐energy nanophotonic applications.
Conjugation and Topology Engineering of 2D π‐d Conjugated Metal–Organic Frameworks for Robust Potassium Organic Batteries
Authors: Cheng Linqi , Qi Meiling , Yu Jie , Zhang Xupeng , Wang Heng‐Guo , Cui Fengchao , Wang Yinghui 
Published: April 2024

AbstractThe evolution of two‐dimensional conjugated metal–organic frameworks (2D c‐MOFs) provides a significant prospect for researching the next generation of green and advanced energy storage systems (ESSs). Especially, conjugation and topology engineering serve as an irreplaceable character in adjusting the electrochemical properties of ESSs. Herein, we proposed a novel strategy using conjugation and topology engineering to demonstrate the application of 2D c‐MOFs in robust potassium‐ion batteries (PIBs) for the first time. By comparing 2D c‐MOFs with the rhombus/kagome structure as well as three/four‐arm core, the rhombus structure (sql‐Cu‐TBA‐MOF) cathode for PIBs can display the impressive electrochemical performance, including a high specific discharge capacity of 178.4 mAh g−1 (at 0.2 A g−1) and a well long‐term cycle stability of more than 9,000 (at 10.0 A g−1). Moreover, full PIBs (FPIBs) are constructed by pairing sql‐Cu‐TBA‐MOF cathode with dipotassium terephthalate (KTP) anode, which delivers a high reversible discharge specific capacity of 146.6 mAh g−1 (at 0.1 A g−1) and great practical application prospect. These findings provide reasonable implications for the design of 2D c‐MOFs from the perspective of conjugation and topology engineering for advanced energy storage systems.
Salmon farming alters the structure and functioning of Norwegian maerl bed communities
Authors: Legrand Erwann , Taormina Bastien , Grall Jacques , Sævik Pål Næverlid , Lelièvre Yann , Pinsivy Lucas , Peña Viviana , Husa Vivian 
Published: April 2024

Abstract

Effluents resulting from fish farming activities can alter the structure and functioning of benthic ecosystems. In Norway, recent technological advances within the salmon industry have facilitated the expansion of aquaculture into shallower locations, leading to additional pressures upon coastal habitats.
Maerl/rhodolith beds are important bioengineers in coastal waters—supporting highly diverse associated macrofaunal communities—and are likely to be particularly at risk.
This study aims to investigate the environmental changes induced by fish farms in their vicinity and their impact on the structure and functioning of maerl bed macrofaunal communities.
High dissolved nutrients and organic enrichment levels were observed close to the cages, associated with lower live maerl cover.
Overall, the most substantial impact of salmon farms on macrofaunal communities was observed within 100 m from the cages. Nevertheless, changes in the structure and functioning of assemblages were evidenced up to 300 m.
In the vicinity of the cages, communities were characterized by the dominance of endobenthic subsurface deposit feeders and opportunistic species, notably the polychaetes Chaetozone sp., Capitella sp. and Scoloplos armiger. Conversely, sites situated farther away from the cages exhibited higher abundances of epibenthic taxa, including crawlers, grazers and species sensitive to organic enrichment.
Sites unaffected by the presence of fish farms were described by high abundances of the ophiuroid Ophiura robusta, the polychaete Proclea graffi and ostracods, reflecting more favourable environmental conditions.
Such changes in macrofaunal communities highlight the vulnerability of maerl beds to the impacts of aquaculture, thus emphasizing the importance of rigorous site selection when establishing new fish farming facilities.
Do religious and cultural considerations militate against body donation? An overview and a Christian perspective
Authors: Jones David Gareth 
Published: April 2024

AbstractThe development of anatomy as a scientific undertaking appears to have left little room for religious and cultural input into the conduct of anatomical investigations. This has been brought to the fore by questionnaires regarding the willingness or otherwise of individuals to donate their bodies for dissection, with higher levels of willingness from those without religious affiliations. This has led to the assumption that there is inherent opposition to body donation by those with a religious stance, although there has been little exploration of this. This is increasingly important with growing awareness that anatomy is an international discipline, leading to increasing attention to the religious and cultural contexts within which it is practiced. There is a diversity of responses toward body donation within different countries, as well as by those influenced by Islam, Hinduism, and Buddhism. Additionally, there are diverse cultural attitudes within Confucianism in Asia, Zulu in Africa, and Māori in New Zealand. Even those within the Christian church are influenced by a variety of values, some of which are in tension, with emphasis on the sacredness of life and the significance of burial being negative toward body donation, with informed consent and altruism pointing in a positive direction. The challenge for anatomists is to understand those within their communities, seek to appreciate their perspectives, and also make known the potential of body donation and dissection for enhancing medical practice and improving the education of future health workers.
Diminishing Self‐Discharge of High‐Loading Li−S Batteries with Oxygen‐Rich Biomass Carbon Interlayers
Authors: Li Wei , Qin Yumei , Dou Xiaojian , Hu Qiong , Liang Wenyu , Nie Guochao , Zhu Gaolong , Zeng Chujie , Zeng Guangfeng 
Published: April 2024

AbstractLithium‐sulfur batteries (Li−S) have possessed gratifying development in the past decade due to their high theoretical energy density. However, the severe polysulfide shuttling provokes undesirable self‐discharge effect, leading to low energy efficiency in Li−S batteries. Herein, an interlayer composed of oxygen‐rich carbon nanosheets (OCN) derived from bagasse is elaborated to suppress the shuttle effect and reduce the resultant self‐discharge effect. The OCN interlayer is able to physically block the shuttling behavior of polysulfides and its oxygen‐rich functional groups can strongly interact with polysulfides via O−S bonds to chemically immobilize mobile polysulfides. The self‐discharge test for seven days further shows that the self‐discahrge rate is diminished by impressive 93 %. As a result, Li−S batteries with the OCN interlayer achieve an ultrahigh discharge specific capacity of 710 mAh g−1 at a high mass loading of 7.18 mg. The work provides a facile method for designing functional interlayers and opens a new avenue for realizing Li−S batteries with high energy efficiency.
Understanding symptom contribution to sex inequality in bladder and renal cancer stage at diagnosis
Authors: Zhou Yin , Lyratzopoulos Georgios , Rajan Prabhakar , Walter Fiona M. , Wu Jianhua 
Published: April 2024

AbstractBackgroundUnderstanding sex‐specific factors contributing to advanced‐stage diagnosis can guide interventions to reduce sex inequality in patients with urological cancers.MethodWe used linked primary care and cancer registry data to examine associations between symptoms and advanced‐stage in 1151 bladder cancer and 440 renal cancer patients diagnosed between January 2012 and December 2015 in England. We performed logistic regression, adjusting for sex, age, deprivation and routes to diagnosis, including interaction terms between symptoms and sex and symptoms and age.ResultsFemale sex (OR vs. men 1.89 [1.28–2.79]; p = 0.001) and patients presenting with urinary tract infections (OR 2.22 [1.34–3.69]) and abdominal symptoms (OR 2.19 [1.30–3.70]) were associated with increased odds of advanced‐stage bladder cancer (vs. haematuria, p = 0.016 for both). Women with haematuria and men with abdominal symptoms (compared with the opposite sex with the same presenting symptom) were more likely to have advanced‐stage bladder cancer. Neither sex nor symptom associations were observed for renal cancer.ConclusionNon‐haematuria symptoms are associated with higher risk of advanced‐stage bladder cancer. Greater risk of advanced‐stage bladder cancer in women may reflect biological differences in haematuria onset and sex differences during diagnostic process. Identifying higher risk women with haematuria may reduce sex inequalities in bladder cancer outcomes.
A new fluorescence probe for sofosbuvir analysis in dosage form and spiked human plasma
Authors: Nasr Mohamed S. , Talaat Wael , Morshedy Samir , Kaddah Mohamed M. Y. , Omran Gamal , Keshk Reda M. 
Published: April 2024

AbstractA simple, rapid, and low‐cost technique was developed to allow reliable analysis of the anti‐hepatitis C drug sofosbuvir in bulk, tablet form, and spiked human plasma. This method depends on the ability of sofosbuvir to quench the fluorescence of the newly synthesized 2‐amino‐3‐cyano‐4,6‐dimethylpyridine (reagent 3). Elemental analysis and spectral data were used to validate the structure of the synthesized reagent. The newly synthesized reagent exhibited a satisfactory level of fluorescence emission at 365 nm after excitation at 247 nm. All experimental variables that might affect the quenching process were analyzed and optimized. Linearity, range, accuracy, precision, limit of detection (LOD), and limit of quantitation (LOQ) were all validated in accordance with the International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use (ICH) guidelines. The concentration range was shown to be linear between 0.1 and 1.5 μg/mL. The technique was effectively utilized for sofosbuvir analysis in both its tablet dosage form and spiked human plasma, with mean percentage recoveries of 100.13 ± 0.35 and 94.26 ± 1.69, respectively.
Development of generic metabolic Raman calibration models using solution titration in aqueous phase and data augmentation for in‐line cell culture analysis
Authors: Zhang Zhijun , Lang Zhe , Chen Gong , Zhou Hang , Zhou Weichang 
Published: April 2024

AbstractThis study presents a novel approach for developing generic metabolic Raman calibration models for in‐line cell culture analysis using glucose and lactate stock solution titration in an aqueous phase and data augmentation techniques. First, a successful set‐up of the titration method was achieved by adding glucose or lactate solution at several different constant rates into the aqueous phase of a bench‐top bioreactor. Subsequently, the in‐line glucose and lactate concentration were calculated and interpolated based on the rate of glucose and lactate addition, enabling data augmentation and enhancing the robustness of the metabolic calibration model. Nine different combinations of spectra pretreatment, wavenumber range selection, and number of latent variables were evaluated and optimized using aqueous titration data as training set and a historical cell culture data set as validation and prediction set. Finally, Raman spectroscopy data collected from 11 historical cell culture batches (spanning four culture modes and scales ranging from 3 to 200 L) were utilized to predict the corresponding glucose and lactate values. The results demonstrated a high prediction accuracy, with an average root mean square errors of prediction of 0.65 g/L for glucose, and 0.48 g/L for lactate. This innovative method establishes a generic metabolic calibration model, and its applicability can be extended to other metabolites, reducing the cost of deploying real‐time cell culture monitoring using Raman spectroscopy in bioprocesses.
Examining the influence of corporate social responsibility performance on earnings management: A global perspective in the context of sustainable development
Authors: Le Anh‐Tuan , Doan Anh‐Tuan 
Published: April 2024

AbstractThis article examines the relationship between corporate social responsibility and earnings management behavior around the world. Using international data from 35 countries between 2003 and 2019, we find evidence that increased corporate social responsibility tends to mitigate the pressure to manage earnings. These findings are robust to alternate measures of earnings management, corporate social responsibility, as well as controlling for endogeneity caveats by two‐stage‐least square and system generalized‐method‐of‐moments estimations. We further show that the negative association between corporate social responsibility and earnings management is more pronounced for firms in countries with high press freedom or high societal trust. The findings from this article provide implications for investors, analysts, business participants, and regulators.
Environmental sustainability and customer experience in emerging markets
Authors: Tsetse Ernest Kafui Kwasi , Adams Russell , Elliot Esi A. , Downey Clara 
Published: April 2024

AbstractIncreasingly, environmental sustainability becomes an important consideration for customer engagement (CE). The globalization of the marketplace has led to a marketing renaissance focused on environmental sustainability, which highlights the importance of our study. Our research question is, therefore, “How does environmental sustainability enhance customer engagement?” We argue that attention to environmental sustainability in emerging markets would significantly enhance CE. Expanding the customer involvement of green‐oriented customers can lead to significant environmental improvement, especially in emerging economies. This study makes significant contributions to research and practice of connecting the environment sustainability to CE in emerging markets. Our study applies a mixed method research design, which involves concurrently using both quantitative and qualitative methods, with quantitative preceding the qualitative and exploratory methods. Our study finds out that CE in emerging markets results in increased environmental sustainability and in this manner, enhances the customer tourism experience.
Withanicandrin Isolated from Datura Ferox Promotes Antinociception by Modulating the Asics and TRPS Channels and Anti‐Inflammation in Adult Zebrafish
Authors: Maciel Jéssica Bezerra , Liberato Hortência Ribeiro , da Silva Antônio Wlisses , da Silva João Pedro Vieira , das Chagas L. Pinto Francisco , de Lima Rebouças Emanuela , da Silva Francisco Sydney Henrique , Ferreira Maria Kueirislene Amâncio , Marinho Marcia Machado , Marinho Emmanuel Silva , Pessoa Otília Deusdênia Loiola , de Barros Silva Paulo Goberlânio , Coelho‐de‐Souza Andrelina Noronha , Guedes Maria Izabel Florindo , de Castro Gomes Andreia Ferreira , de Menezes Jane Eire Silva Alencar , dos Santos Hélcio Silva 
Published: April 2024

AbstractThis is the first study to analyze the anti‐inflammatory and antinociceptive effect of withanicandrin, isolated from Datura Ferox leaves, and the possible mechanism of action involved in adult zebrafish (ZFa). To this end, the animals were treated intraperitoneally (i. p.) with withanicandrin (4; 20 and 40 mg/kg; 20 μL) and subjected to locomotor activity and acute toxicity. Nociception tests were also carried out with chemical agents, in addition to tests to evaluate inflammatory processes induced by κ‐Carrageenan 1.5 % and a Molecular Docking study. As a result, withanicandrin reduced nociceptive behavior by capsaicin at a dose of 40 mg/kg and by acid saline at doses of 4 and 40 mg/kg, through neuromodulation of TRPV1 channels and ASICs, identified through blocking the antinociceptive effect of withanicandrin by the antagonists capsazepine and naloxone. Furthermore, withanicandrin caused an anti‐inflammatory effect through the reduction of abdominal edema, absence of leukocyte infiltrate in the liver tissue and reduction of ROS in thel liver tissue and presented better affinity energy compared to control morphine (TRPV1) and ibuprofen (COX‐1 and COX‐2).
Comparison of the Secondary Metabolism of the Basidiomycetes Armillaria mellea and Desarmillaria ectypa
Authors: Chepkemoi Jacklyne , Pfütze Sebastian , Kimani Njogu M. , Matasyoh Josphat C , Stadler Marc 
Published: April 2024

AbstractDuring the course of our ongoing studies on the secondary metabolism of cultures of Basidiomycota, a new meroterpenoid named 10, 15‐dihydroxydihydromelleolide (1) was isolated along with the known armillaridin (2) and arnamiol (3) from cultures of the rare saprotrophic species, Desarmillaria ectypa. These are the first secondary metabolites that were ever isolated from the latter species. A concurrently studied strain of the common pathogenic A. mellea yielded other melleolides, with 5’‐O‐methylmelledonal (4), melledonal C (5), 10 α‐hydroxydihydromelleolide (6) and melledonal (7). The chemical structures were elucidated using 1D and 2D NMR spectroscopy and high‐resolution electrospray ionization mass spectrometry (HR‐ESI‐MS). All compounds were studied for their antimicrobial and cytotoxic effects against a panel of microbes and mammalian cell lines, and the results are also reported.
Proteomic Profiling of Antimalarial Plasmodione Using 3‐Benz(o)ylmenadione Affinity‐Based Probes
Authors: Iacobucci Ilaria , Monaco Vittoria , Hovasse Agnès , Dupouy Baptiste , Keumoe Rodrigue , Cichocki Bogdan , Elhabiri Mourad , Meunier Brigitte , Strub Jean‐Marc , Monti Maria , Cianférani Sarah , Blandin Stéphanie A. , Schaeffer‐Reiss Christine , Davioud‐Charvet Elisabeth 
Published: April 2024

AbstractUnderstanding the mechanisms of drug action in malarial parasites is crucial for the development of new drugs to combat infection and to counteract drug resistance. Proteomics is a widely used approach to study host‐pathogen systems and to identify drug protein targets. Plasmodione is an antiplasmodial early‐lead drug exerting potent activities against young asexual and sexual blood stages in vitro with low toxicity to host cells. To elucidate its molecular mechanisms, an affinity‐based protein profiling (AfBPP) approach was applied to yeast and P. falciparum proteomes. New (pro‐) AfBPP probes based on the 3‐benz(o)yl‐6‐fluoro‐menadione scaffold were synthesized. With optimized conditions of both photoaffinity labeling and click reaction steps, the AfBPP protocol was then applied to a yeast proteome, yielding 11 putative drug‐protein targets. Among these, we found four proteins associated with oxidoreductase activities, the hypothesized type of targets for plasmodione and its metabolites, and other proteins associated with the mitochondria. In Plasmodium parasites, the MS analysis revealed 44 potential plasmodione targets that need to be validated in further studies. Finally, the localization of a 3‐benzyl‐6‐fluoromenadione AfBPP probe was studied in the subcellular structures of the parasite at the trophozoite stage.
Safety and efficacy of drug‐eluting stents for patients at high risk of bleedings: A network meta‐analysis
Authors: Giacobbe Federico , Valente Eduardo , Morena Arianna , Nebiolo Marco , Giannino Giuseppe , De Filippo Ovidio , Bruno Francesco , Isaevska Elena , Richiardi Lorenzo , Iannaccone Mario , Zoccai Giuseppe Biondi , Burzotta Francesco , D'Ascenzo Fabrizio , Ferrari Gaetano Maria De 
Published: April 2024

AbstractIntroductionAmong different coronary stents implanted in High Bleeding Risk (HBR) patients with an indication for short antiplatelet therapy, no comparisons in terms of efficacy have been provided.MethodsA Network Meta Analysis was performed including all randomized controlled trials comparing different coronary stents evaluated in HBR patients. Major Adverse Cardiovascular Events (MACEs) as defined by each included trial were the primary end point, whereas TLR (target lesion revascularization), TVR (target vessel revascularization), stent thrombosis and total and major (BARC3‐5) bleedings were the secondary ones.ResultsA total of four studies (ONYX ONE, LEADERS FREE, SENIOR and HBR in BIO‐RESORT) including 6637 patients were analyzed with different kind of stents and dual antiplatelet therapy (DAPT) length (1 or 6 months) on 12 months follow‐up. About one‐third of these patients were defined HBR due to indication for oral anticoagulation. All drug eluting stents (DESs) reduced risk of MACE compared to Bare Metal Stents (BMSs) when followed by a 1‐month DAPT. At SUCRA analysis, Orsiro was the device with the highest probability of performing best. Rates of TLR and TVR were significantly lower when using Resolute Onyx, Synergy and BioFreedom stents in comparison to BMS when followed by 1‐month DAPT, with Synergy ranking best. Synergy also showed a significantly lower number of stent thrombosis compared to BMS (RR 0.28, 95% CI 0.06−0.93), while Orsiro and Resolute Integrity showed the highest probability of performing best.ConclusionIn HBRs patients, all DESs were superior to BMSs in terms of efficacy and safety. Among DESs, Orsiro was the one with the highest ranking in terms of MACE, mainly driven by a reduced incidence of repeated revascularization and stent thrombosis