bluuebunny/crossref_metadata_2025_split huggingface dataset:
A mouse line expressing Foxa2‐driven Cre recombinase in node, notochord, floorplate, and endoderm
Authors: Uetzmann Lena , Burtscher Ingo , Lickert Heiko 
Published: September 2008

AbstractFoxa2 is a forkhead transcription factor expressed in the node, notochord, floorplate, and definitive endoderm and is required in the foregut endoderm for the normal development of the endoderm‐derived organs, such as the liver, lung and pancreas. To conditionally inactivate genes in these tissues and organs, we have targeted a Cre recombinase into Exon 1 of the Foxa2 gene. We show, upon crossing to the ROSA26 reporter mice, that Cre expression from the Foxa2iCre knock‐in allele specifically activates β‐galactosidase expression in the node, notochord, floorplate, and endoderm. In addition, we detect Cre recombination activity in the endoderm‐derived organs including lung, liver, pancreas, and gastrointestinal tract throughout development. These results demonstrate that the Foxa2iCre knock‐in mice are a valuable tool to analyze gene function in endoderm progenitors and endoderm‐derived organs. Moreover, the widespread β‐galactosidase reporter activity in the endoderm suggests that Foxa2 marks a progenitor cell population, which gives rise to the majority of cells in endoderm‐derived organs. genesis 46:515–522, 2008. © 2008 Wiley‐Liss, Inc.
Synthesis and Characterization of Linear Trinuclear Pd, Co, and Pd/Co Pyrazolate Complexes
Authors: Miras Haralampos N. , Zhao Hong , Herchel Radovan , Rinaldi Carlos , Pérez Soribel , Raptis Raphael G. 
Published: September 2008

AbstractA family of dinuclear and linear trinuclear Co/Pd pyrazolate compounds, namely, [Bu4N]2[Co2(μ‐4‐Cl‐3,5‐Me2‐pz)2Cl4] (1), [Bu4N]2[Co2(μ‐4‐Br‐3,5‐Me2‐pz)2Br4] (2), [Bu4N]2[Co2(4‐I‐3,5‐Me2‐pz)2Cl4] (3), [Et4N]2[Pd2Co(4‐Br‐3,5‐Me2‐pz)4Cl4] (4), [Et3NH]4[PdCo2(4‐Br‐3,5‐Me2‐pz)4Cl4][NO3]2 (5), [Et3NH]2[Pd Co2(3‐Me‐5‐Ph‐pz)4Cl4] (6), [Et3NH]2[Pd3(4‐Br‐3,5‐Me2‐pz)4Cl4] (7), and [Co3(3,5‐Me2‐pz)4(3,5‐Me2‐pzH)2(CH3CO2)2] (8) was synthesized. The single‐phase nature of the solids was established by single‐crystal X‐ray diffraction, thermal analysis, and spectroscopic techniques. Moreover, the magnetic behavior is studied and a magnetostructural comparison to the corresponding carboxylate analogues is made. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
A (Nitrido)chromium(V) Function Incorporated in a Keggin‐Type Polyoxometalate: [PW11O39CrN]5– – Synthesis, Characterization and Elements of Reactivity
Authors: Lahootun Vanina , Karcher Jeff , Courillon Christine , Launay Franck , Mijares Kristopher , Maatta Eric , Proust Anna 
Published: September 2008

AbstractThe (nitrido)chromium(V) derivative [PW11O39{CrN}]5– (1a) was synthesized by the reaction of the monolacunary [H3PW11O39]4– polyanion with a {CrN}2+ function generated in situ. The EPR spectrum of the formed polyoxometalate confirmed the presence of a paramagnetic CrV complex, and the presence of the nitrido bond was inferred by IR spectroscopy. The reactivity of [PW11O39{CrN}]5– was investigated and evidence of nucleophilic behaviour towards trifluoroacetic anhydride, forming the acylimido derivative [PW11O39{CrVNCOCF3}]4– (2a), is also reported. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Nano‐CuO‐Catalyzed Ullmann Coupling of Phenols with Aryl Halides under Ligand‐Free Conditions
Authors: Zhang Jintang , Zhang Zuhui , Wang Ye , Zheng Xiaoqi , Wang Zhiyong 
Published: September 2008

AbstractNano copper oxide has been found to be a highly efficient and reusable catalyst for the C–O cross‐coupling of phenols with aryl halides under ligand‐free conditions. With DMSO as solvent, Cs2CO3 and KOH are suitable bases for the cross‐coupling reactions with phenyl iodides and bromides, respectively. Diaryl ethers with different substituted groups can be synthesized in moderate‐to‐good yields. The catalyst can be recycled at least five times without obvious loss in catalytic activity.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Rearrangement of Differentially Protected N‐Arylhydroxylamines
Authors: Porzelle Achim , Woodrow Michael D. , Tomkinson Nicholas C. O. 
Published: September 2008

AbstractThe rearrangement of a series of N,O‐difunctionalised N‐arylhydroxylamines to generate protected 2‐aminophenols has been investigated. N‐Boc‐N‐Aryl‐O‐acylhydroxylamines are stable, isolable compounds which rearrange smoothly at temperatures between 110 and 140 °C. The corresponding N‐Boc‐N‐aryl‐O‐sulfonylhydroxylamines were not isolated and rearrange to 1,2‐difunctionalised aminophenols at room temperature in excellent yield. Deprotection of either the N‐ or O‐substituents under standard conditions allows for further synthetic manipulation of either the aniline or phenol functionality.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
The Intricate Assembling of gem‐Diphenylpropargylic Units
Authors: Maraval Valérie , Duhayon Carine , Coppel Yannick , Chauvin Remi 
Published: September 2008

AbstractWhile optimized procedures for selective propargylic – versus allenic – attack (in particular by alkynylsilanes) have proven to be compatible with many substitution patterns at the propargylic center, the case of diarylpropargyl electrophiles has remained problematic. The intrinsic reactivity of 1,1‐diphenylpropargylic alcohols [R–C≡C–C(Ph2)OH (R = TMS, H, Me)] in the presence of various acids (and in the absence of additional nucleophile) has thus been systematically investigated. Whereas the monophenyl analogues [R–C≡C–CH(Ph)OH] afford the expected bis(phenylpropargyl) ethers, the diphenyl versions undergo complex but quite selective processes to afford various structural types: depending on the acid used, a diallene, an allenyne, an indenylallene, an indanone or a condensed tetra‐ and pentacycles were obtained. When the reactions were conducted in the presence of an alkynylsilane capable of playing the role of a competing nucleophile, the expected propargylic substitution products – dialkynyldiphenylmethanes or their isomers – were never observed. The hitherto unknown simple hydrocarbons diethynyl‐ and dipropynyl‐diphenylmethane could, however, be obtained in low yields through a four‐step sequence involving allenylidene‐ and alkynylruthenium intermediates.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Catalytic Enantioselective α‐Oxysulfonylation of Ketones Mediated by Iodoarenes
Authors: Altermann Sabine M. , Richardson Robert D. , Page T. Keri , Schmidt Ruth K. , Holland Edward , Mohammed Umal , Paradine Shauna M. , French Andrew N. , Richter Christine , Bahar A. Masih , Witulski Bernhard , Wirth Thomas 
Published: September 2008

AbstractThe α‐oxysulfonylation of ketones catalysed by enantioenriched iodoarenes using mCPBA as stoichiometric oxidant is reported to give useful synthetic intermediates in good yield and modest enantioselectivity. We believe this to be the first report of an enantioselective organocatalytic reaction involving hypervalent iodine reagents which should open up a new field for enantioselective organocatalysis of oxidation reactions. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Archaeal Lipids: Innovative Materials for Biotechnological Applications (Eur. J. Org. Chem. 28/2008)
Authors: Benvegnu Thierry , Lemiègre Loïc , Cammas‐Marion Sandrine 
Published: September 2008

AbstractThe cover picture shows the molecular structure of monopolar diether‐type and bipolar tetraether‐type lipids found in archaea membranes as well as a schematized representation of an archaeosome–DNA complex based on archaeal lipids. The background offers a view of archaeosomes (cross‐fractured vesicles made from synthetic archaeal bipolar lipids) observed by freeze‐fracture electron microscopy. Details of the structure and properties of these original natural or synthetic lipids and their potential biotechnological applications are presented in the Microreview by T. Benvegnu et al. on p. 4725 ff.
The effects of authentic and contrived dissent on escalation of commitment in group decision making
Authors: Greitemeyer Tobias , Schulz‐Hardt Stefan , Frey Dieter 
Published: September 2008

AbstractEscalation of commitment refers to the tendency to persist with or even intensify losing courses of action. In this study, we examined whether authentic and contrived dissent reduces escalation in group decision making. Participants first individually indicated their preference on how to allocate money between two alternatives. Based on these individual preferences, homogeneous and heterogeneous three‐person groups were formed. In addition, group discussion was either structured by assigning one group member to play the role of a devil's advocate or was not structured. Results revealed that escalation tendencies over multiple decisions were reduced in heterogeneous groups that used the devil's advocacy procedure. The rationality of this behavior is discussed. Copyright © 2008 John Wiley & Sons, Ltd.
Voltammetric Studies on the Recognition of a Copper Complex to Single‐ and Double‐Stranded DNA and Its Application in Gene Biosensor
Authors: Wang Qing Xiang , Gao Feng , Jiao Kui 
Published: September 2008

AbstractA mixed‐ligands copper complex [Cu(phendione)(DAP)]SO4 (phendione=1,10‐phenanthroline‐5,6‐dione, DAP=2,3‐diaminophenazine) was synthesized. Cyclic voltammetry showed that the complex underwent an obvious decrease of redox peak currents and positive shift of formal potential after interaction with double‐stranded DNA (dsDNA), suggesting that the copper complex behaved as a typical metallointercalator for dsDNA, The recognition properties of the copper complex to single‐stranded DNA (ssDNA) and dsDNA were assessed using surface‐based electrochemical methods and the results suggested that the complex had obviously different redox signals at ssDNA and dsDNA modified electrodes. The copper complex was further used as an electroactive indicator for the detection of cauliflower mosaic virus (CaMV) 35S promoter gene.
Self‐Assembled Redox System for Bioelectrocatalytic Assay of L‐Ascorbylphosphate and Alkaline Phosphatase Activity
Authors: Kazakevičienė Birutė , Valinčius Gintaras , Kažemėkaitė Marytė , Razumas Valdemaras 
Published: September 2008

AbstractFerrocene‐terminated self‐assembled monolayer (Fc‐SAM) on gold was used as an electron‐transfer mediator in the electrochemical assay of L‐ascorbic acid 2‐phosphate (AAP). The assay is based on the enzymatic action of alkaline phosphatase (ALP), which triggers the release of vitamin C (L‐ascorbic acid, AA) from AAP. The latter is easily oxidized on the Fc‐SAM under the diffusion limiting conditions that favors quantitative measurement of the AA concentration on a rotating disk electrode. We demonstrate the utility of the electrochemically active Fc‐SAM to probe the mechanism and to determine the kinetic parameters of an enzymatic reaction. The electrochemical technique was compared to a conventional spectrophotometric method of ALP activity detection using p‐nitrophenylphosphate (p‐NPP) as a substrate. We demonstrate that our new technique is also suitable for the analytical determination of ALP activity. The detection limits for both AAP and ALP were found to be 13 μM and 2 pM, respectively.
Analysis of air quality monitoring networks by functional clustering
Authors: Ignaccolo R. , Ghigo S. , Giovenali E. 
Published: September 2008

AbstractAir quality monitoring networks are important tools in management and evaluation of air quality. Classifying monitoring stations via homogeneous clusters allows e dentification of similarities in pollution, of representative sites, and of spatial patterns. Instead of summaries by statistical indicators, we propose to consider the air pollutant concentrations as functional data. We then classify using functional cluster analysis, where Partitioning Around Medoids (PAM) algorithm is embedded. The proposed data analysis approach is applied to the air quality monitoring network in Piemonte (Northern Italy); we consider the three more critical pollutants: NO2, PM10, and O3. Copyright © 2008 John Wiley & Sons, Ltd.
An idealised model of turbulent dispersion: two rectangular pulse initial condition
Authors: Mole Nils , Ring Rebecca 
Published: September 2008

AbstractAn idealised model of turbulent dispersion was introduced by Zimmerman and Chatwin in 1995 and it was further developed by Mole and Yeun in 2007, for the case of an initial concentration field consisting of one rectangular pulse. Here we extend this model to the case of two initial pulses in order to investigate the effect of varying concentration. We present analytical and numerical results for the dependence of the variance, skewness, kurtosis and probability density function of concentration on time and on the pulse locations and concentrations. For moderately large concentration difference between the pulses, one pulse dominates and the behaviour is close to that for the one pulse case. This suggests that a model incorporating distributions of pulse separations and concentrations can be constructed by averaging over an ensemble of one pulse cases. The distributions used would be those appropriate to the ‘strands’ of highest concentration. Copyright © 2008 John Wiley & Sons, Ltd.
Network bias in air quality monitoring design
Authors: Loperfido Nicola , Guttorp Peter 
Published: September 2008

AbstractWe develop a statistical model for the bias resulting from designing an air quality monitoring network with the aim of finding large values, and then using the data obtained in studies of health effects of air quality. Appropriate conditional distributions are shown to be well‐known generalizations of the normal one. Theoretical results are applied to an ozone monitoring network in the state of Washington, USA. Copyright © 2008 John Wiley & Sons, Ltd.
A fully 3D finite element model for non‐hydrostatic coastal flows with a free surface
Authors: Blasco Jordi , Maidana M. Augusto , Espino Manuel 
Published: September 2008

AbstractIn this paper we develop a finite element model, named HELIKE, for the numerical simulation of 3D, non‐hydrostatic, turbulent flows with a free surface like those arising from the study of the motion of water in coastal regions. The kinematic free‐surface equation is used to compute the surface elevation, without resorting to vertical averages. The model presented here incorporates surface wind stress, bottom friction and Coriolis acceleration, and it is applicable to irregular bottom topographies. A pressure stabilization technique is employed to stabilize the finite element solution. Numerical results obtained both in test problems and in a real‐life application confirm the accuracy, robustness and applicability of the proposed method. Copyright © 2008 John Wiley & Sons, Ltd.
Oral histoplasmosis: An unusual presentation
Authors: Narayana Nagamani , Gifford Ryan , Giannini Peter , Casey John 
Published: September 2008

AbstractBackground.Histoplasmosis is a localized or systemic fungal infection which may present as an acute primary or “reactivation” infection in the setting of immunosuppression. Tumor necrosis factor alpha (TNF‐α) antagonists, used in the management of rheumatoid arthritis and Crohn disease, have been linked to reactivation of quiescent histoplasmosis. Microscopically, granulomas are either not evident or are infrequent in histoplasmosis when associated with TNF antagonist therapy presumably due to the suppression of macrophage activity.Methods and Results.This article describes an unusual presentation of oral histoplasmosis in a 75‐year‐old‐woman patient on TNF‐α antagonist, namely infliximab. Microscopically, cellular atypia resulted in a work‐up to rule out lymphoma. Gomori's methenamine silver stain demonstrated Histoplasma capsulatum leading to a diagnosis of histoplasmosis. She was treated successfully with itraconozole.Conclusion.This is the first reported case, insofar as the authors are able to determine, of oral histoplasmosis, in a patient undergoing treatment with infliximab. © 2008 Wiley Periodicals, Inc. Head Neck, 2009
Comparison of ultrasound‐guided core‐needle biopsy and fine‐needle aspiration in the assessment of head and neck lesions
Authors: Kraft Marcel , Laeng Hubert , Schmuziger Nicolas , Arnoux André , Gürtler Nicolas 
Published: September 2008

AbstractBackground.Core‐needle biopsy (CNB) has been successfully applied in other medical specialties, but its value is undetermined in otolaryngology.Methods.This prospective study includes 75 patients, who were seen at our institution with a cervical mass. The results of CNB were compared with those of fine‐needle aspiration (FNA) in the 68 histologically verified cases.Results.CNB was superior to FNA providing a specific diagnosis (90% vs 66%) and achieved a higher accuracy in identifying true neoplasms (100% vs 93%) and detecting malignancy (99% vs 90%). However, the sensitivity and specificity did not differ significantly between both methods.Conclusions.Sonography and if necessary FNA should continue to be the investigation method of first choice for head and neck lesions. The main indication for CNB is after repeated failures of FNA to provide a diagnosis. It can also be performed in patients who are not surgical candidates or in those who refuse surgery. © 2008 Wiley Periodicals, Inc. Head Neck, 2008
Nodal metastases at level IIb during neck dissection for head and neck cancer: Clinical and pathologic evaluation
Authors: Santoro Roberto , Franchi Alessandro , Gallo Oreste , Burali Giulia , de' Campora Enrico 
Published: September 2008

AbstractBackground.Selective neck dissection as a part of an elective or therapeutic treatment of the neck is a common practice during the surgical treatment of patients with head and neck cancer. Recently, the need for routine dissection of level IIb has been discussed. The aim of this study was to verify the incidence of metastases at level IIb in patients with clinically negative necks (N0) and clinically positive necks (N+) and discuss the need for its excision.Methods.A total of 114 patients with head and neck cancer undergoing neck dissection were prospectively analyzed. The total number of neck dissections analyzed was 148. The surgical specimens from each node level of the neck were pathologically diagnosed, with special attention to level IIb. Univariate associations between N classification and IIb positive cases were assessed using logistic regression and between IIa and IIb positive cases using Fisher exact test.Results.Of 148 neck dissections performed, level IIb resulted positive in 5 cases (3.3%): 1 patient with laryngeal cancer, 1 patient with oral cavity cancer, and 2 patients with oropharyngeal cancer, of which 1 underwent bilateral neck dissection. According to clinical N classification, for N0 and N+ the incidence of positive level IIb was 2% and 5%, respectively. All the cases with metastases at level IIb also showed metastases at level IIa. A statistically significant association between the presence of nodal metastases at level IIb and those at level IIa (p <.001) was found. The statistical association between N classification and IIb positive nodes only showed a trend toward significance (p = .06).Conclusions.The incidence of metastases at level IIb is low, also in the N+ necks, therefore dissection of this level could be unnecessary in N0 necks. Furthermore, an interesting statistical association between the presence of metastases at level IIb and at level IIa was recorded. © 2008 Wiley Periodicals, Inc. Head Neck, 2008
Diabetes insipidus and panhypopituitarism due to intrasellar metastasis from medullary thyroid cancer
Authors: Santarpia Libero , Gagel Robert F. , Sherman Steven I. , Sarlis Nicholas J. , Evans Douglas B. , Hoff Ana O. 
Published: September 2008

AbstractBackground.Medullary thyroid cancer (MTC) commonly metastasizes to lymph nodes in the central and lateral neck, but spread to distant organs also occurs, typically involving lung, liver, and bone. Metastases to pituitary gland are rare for this tumor.Methods.We describe an unusual case and peculiar presentation of pituitary metastasis from MTC. We report clinical, genetic, and laboratory data of this patient.Results.A young woman with multiple endocrine neoplasia type 2B was seen with recent onset of classic symptoms and signs of panhypopituitarism, mild diabetes insipidus, and optic chiasmatic compression. Transphenoidal resection of an intrapituitary mass confirmed the presence of metastatic MTC.Conclusions.MTC recurrence may present solely with subacute pituitary symptomatology, even in the context of a very lengthy interval after initial surgery, atypically low calcitonin plasma levels, carcinoembryonic antigen doubling times, and the concomitant absence of other tell‐tale signs of disseminated metastatic disease. © 2008 Wiley Periodicals, Inc. Head Neck, 2009
The role of algorithm and result comprehensibility of automated scheduling on complacency
Authors: Cegarra Julien , Hoc Jean‐Michel 
Published: September 2008

AbstractSeveral studies have stressed that even expert operators who are aware of a machine's limits could adopt its proposals without questioning them (i.e., the complacency phenomenon). In production scheduling for manufacturing, this is a significant problem, as it is often suggested that the machine be allowed to build the production schedule, confining the human role to that of rescheduling. This article evaluates the characteristics of scheduling algorithms on human rescheduling performance, the quality of which was related to complacency. It is suggested that scheduling algorithms be characterized as having result comprehensibility (the result respects the scheduler's expectations in terms of the discourse rules of the information display) or algorithm comprehensibility (the complexity of the algorithm hides some important constraints). The findings stress, on the one hand, that result comprehensibility is necessary to achieve good production performance and to limit complacency. On the other hand, algorithm comprehensibility leads to poor performance due to the very high cost of understanding the algorithm. © 2008 Wiley Periodicals, Inc.
Comparing stationary standing with an intermittent walking posture during assembly operations
Authors: Balasubramanian Venkatesh , Adalarasu Kanagasabai , Regulapati Rahul 
Published: September 2008

AbstractThe purpose of this investigation was to evaluate two different standing postures, intermittent walking (dynamic) and stationary, on 11 volunteers. While performing the activity in a stationary posture, volunteers worked barefoot for 25 minutes at a particular workstation, taking up to five passive breaks. The dynamic standing postural activity was similar in every respect with the exception of the nature of the breaks that were spent walking from one workstation to the other. Foot pressure was analyzed using a static evaluation variable (contact area) and a dynamic evaluation variable (area pressure change root mean square [aPcrms]). Foot center of pressure (COP) was analyzed using two of its features: excursion length (LEN) and root mean square velocity of excursions (VEL). In addition, a psychophysical study was used to distinguish the comfort levels of various muscles between the two postures. The quantifications of the four physiological variables revealed a lower comfort index (p < 0.05) in stationary standing compared to dynamic standing during assembling duties. This significant distinction was further corroborated by the results of the psychophysical test. Such a positive influence of the dynamic standing posture on standing comfort can be used to improve industrial productivity. © 2008 Wiley Periodicals, Inc.