bluuebunny/crossref_metadata_2025_split huggingface dataset:
Guided coronally advanced flap to treat gingival recession: Digital workflow and case report
Authors: Santamaria Mauro Pedrine , Rossato Amanda , Miguel Manuela Maria Viana , Mathias‐Santamaria Ingrid Fernandes , Nunes Marcelo Pereira , Queiroz Lucas Araújo 
Published: March 2024

AbstractBackgroundThe inherently technique‐sensitive nature of periodontal plastic procedures demands a significant level of skill and expertise. The incorporation of three‐dimensional (3D) printing technologies emerges as a potential strategy to optimize and simplify surgical procedures. This case report describes the digital workflow and presents the clinical outcomes achieved using a guided coronally advanced flap for the treatment of a single gingival recession (GR).Methods and ResultsA female patient with a gingival recession type 1 (RT1 B‐) defect on the mandibular second left premolar underwent successful treatment using a guided coronally advanced flap (g‐CAF) and de‐epithelized connective tissue graft (CTG). The digital planning included intraoral scanning of the mandible and hard palate using an intraoral scanner, with resulting polygon format (PLY) files exported for virtual model creation. The CAF guide was meticulously designed to orient horizontal and vertical incisions at the papillae base adjacent to the GR defect. For the donor site, a guide was specifically created, positioning the graft area 2 mm apically to the premolars' gingival margins. The delineation of this area involved two horizontal and vertical incisions, meticulously based on the dimensions of the GR. The digitally designed guides were then 3D‐printed using a surgical guide‐specific resin, contributing to the precise execution of the innovative surgical approach. Complete root coverage was achieved.ConclusionThis case report demonstrates that g‐CAF can be a promising approach for the treatment of single GR.HighlightsWhy is this case new information?

To the best of the authors' knowledge, this is the first manuscript to report a guided procedure for the treatment of gingival recession.
This report provides the digital workflow for the fabrication of a guide to perform the coronally advanced flap for single recession defects.
What are the keys to successfully manage this case?

It is necessary to adequately scan the recession defect area and palate.
Properly not only design the guide using specific software but also print it.
The guide has to be stable when in position for the surgical procedure.
What are the primary limitations of this technique?

This guide was designed to help surgeons during the incisions. However, it does not provide aid to split and release the flap and suture.
Curcumae Radix: A Review of Traditional Use, Phytochemistry, Pharmacology, Toxicology and Quality Control
Authors: Niu Yu‐Ting , Xu Hao‐Nan , Zhang Yu‐Ying , Li Xin‐Zhuo , Li Yu‐Ze , Song Xiao‐Mei , Zhang Dong‐Dong , Wang Wei 
Published: March 2024

AbstractCurcumae Radix (CuR) is a traditional Chinese medicine that has been used in China for more than 1,000 years. It has the traditional efficacy of activating blood and relieving pain, promoting qi and relieving depression, clearing heart and cooling blood, and promoting gallbladder and removing jaundice. Based on this, many domestic and foreign scholars have conducted systematic studies on its chemical composition, pharmacological effects, toxicity and quality control. Currently, 250 compounds, mainly including terpenoids and curcuminoids, have been isolated and identified from CuR, which has pharmacological activities, including antitumor, anti‐inflammatory and analgesic, antidepressant, hepatoprotective, hemostatic, hematopoietic, and treatment of diabetes mellitus. In modern clinical practice, CuR is widely used in the treatment of tumors, breast hyperplasia, hepatitis, and stroke. However, the generation of toxicity and clinical application of CuR and Caryophylli Flos, the determination of the concoction process of artifacts, the determination of specific Quality Marker, and the establishment of the quality control system of CuR, are problems that need to be solved urgently at present.
Synthesis, Antimicrobial Evaluation, DFT, and Molecular Docking Studies of Pyrano [4,3‐b] Pyranone and Pyrano[2,3‐b]Pyridinone Systems
Authors: Ghaith Eslam A. , Zoorob Hanafi H. , Hamama Wafaa S. 
Published: March 2024

AbstractDehydroacetic acid (DHA) was utilized as a fundamental precursor in the synthesis of novel pyrano [4,3‐b] pyran and pyrano [2,3‐b] pyridine systems. Whereas, a new series of fused polyheteronuclear systems was achieved through the reaction of DHA with active methylene compounds such as malononitrile and pyrazolone. Whereas, the treatment of DHA 1 with cyclic ketones involving cyclohexanone and cyclododecanone afforded annulated tricyclic system 6 and spiro hybrid molecule 7. Also, the reaction of DHA 1 with cyanoacetamide derivatives 8 and 11 yielded their corresponding novel pyrano [2,3‐b] pyridine‐6‐carbonitrile frameworks 9 and 12, respectively. Also, in silico predictive theoretical molecular docking studies for bioactive synthesized scaffolds against both HER2 and 6BBP displayed an optimistic result for compounds 2 b, 5, 9, and 12 highlighting their expediency as up–and–coming candidates for future preclinical trials. Additionally, all compounds were assessed as antibacterial agents against various types of four candidates of bacteria in the presence of ampicillin as a reference. Notably, compounds 6, 7, and 12 showed promising antibacterial potential against Bacillus subtilis with activity indexes (69.6, 91.3, and 82.6 %), respectively.
Mechanistic Studies of Continuous Partial Methane Oxidation on Cu−Zeolites Using Kinetic and Spectroscopic Methods
Authors: Mikes Andrew D. , Kilburn Lauren , Gounder Rajamani 
Published: March 2024

AbstractOver the past few decades, a significant amount of research effort has focused on investigating the active site requirements and reaction mechanisms for partial methane oxidation (PMO) to methanol over copper–exchanged zeolites during stoichiometric and stepwise chemical looping routes. More recently, research efforts have expanded to include investigating the PMO reaction in a continuous catalytic regime, primarily focusing on determining the influence of catalyst composition on Cu speciation and structure and, in turn, on PMO rate and selectivity. The structures of candidate Cu active sites are commonly studied using a combination of ex situ and in situ spectroscopic approaches. In this perspective, we critically examine the prior literature on catalytic PMO over Cu–zeolites to identify key knowledge gaps that remain in our understanding as motivation for future research efforts. We identify opportunities for future research to address these gaps by adapting analogous interrogation techniques that have been successfully used to elucidate the active site requirements and mechanistic details of another catalytic redox reaction cycle on Cu–zeolites, the selective catalytic reduction (SCR) of nitrogen oxides (NOx).
First Insight into the Catalytic Activity of Stereolithographically 3D‐Printed Tannin‐Based Carbon Architectures
Authors: Blyweert Pauline , Restivo João , Soares Olivia S. G. P. , Nicolas Vincent , Fierro Vanessa , Pereira Manuel F. R. , Celzard Alain 
Published: March 2024

AbstractThe remediation of polluted water is a major concern for public health and the environment. Catalytic removal of model organic and inorganic pollutants in water using carbon catalysts has shown promising results. In the present work, stereolithographically 3D‐printed bio‐based carbon monoliths with different textural and surface chemistry properties were used as catalysts for oxalic acid oxidation and catalyst supports for bromate reduction in continuous systems. A significant synergistic effect between ozone or dihydrogen and carbon catalyst was evidenced by mineralization of 14–25 % of oxalic acid or reduction of 15–45 % of bromates in the steady state, respectively. The best results were achieved with samples with the highest mesoporous surface area or, in the case of lower surface area, with samples having the strongest basic character. As materials with great potential, optimizing the textural properties of architected carbon monoliths will enable them to compete with other macro‐structured carbon catalysts.
A Review on Virgin or Waste Polymers in Bitumen Modification for Ageing and Rejuvenation
Authors: Rashid Sabina , Mudavath Ravi , Chandra Harish , Shekhar Indu , Kumar Pradeep , Srivastava Manoj , Kumar Kamal 
Published: March 2024

AbstractThe physicochemical behavior of polymer‐modified binders suggests suitability for rejuvenating aged pavements and meets base bitumen parameters. The strengthening effect is mainly due to their electronic structures, which interact with asphaltene via CH‐π interactions and crosslinkage reaction with S–H and O–H bonds of base bitumen, along with the virgin and waste polymers used. The functional groups in bitumen play a vital role in enhanced paving resistance after modification. This review aims to provide an overview of the current knowledge on the role of polymers in bitumen modification and to identify research gaps. It also discusses underutilized technologies, methods, and future research perspectives to implement more effective road networks for an environmentally sustainable development.
Screen‐Printed Composite LiFePO4‐LLZO Cathodes Towards Solid‐State Li‐ion Batteries
Authors: Molaiyan Palanivel , Valikangas Juho , Sliz Rafal , Ramteke D. D. , Hu Tao , Paolella Andrea , Fabritius Tapio , Lassi Ulla 
Published: March 2024

AbstractLiFePO4 (LFP) is widely used as cathode material for its low cost, high safety, and good thermal properties. It is one of the most exploited cathode materials for commercial Li‐ion batteries (LIBs). Herein, we present a screen‐printing method to prepare a LFP composite cathode, and a rational combination of the typical composite solid electrolytes (CSE) consisting of polyethylene oxide (PEO)/Li‐salt (LiTFSi) electrolyte with ceramic filler (LLZO or Li6.4La3Zr1.4Ta0.6O12 (LLZTO)) has been successfully demonstrated for SSB. The prepared CSE offers: i) a promising ionic conductivity (0.425 mS cm−1 at 60 °C), ii) a wide electrochemical window (>4.6 V), iii) a high Li‐ion transference number (tLi+=0.44), iv) a good interfacial compatibility with the electrode, v) a good thermal stability, and vi) a high chemical stability toward Li metal anode. The Li/CSE/Li symmetric cells can be cycled for more than 1000 h without Li‐dendrites growth at a current density of 0.2 mA cm−2. The final cell screen‐printed LFP composite cathode (LFP+LLZO)//Li metal displays a high reversible specific capacity of 140 mAh g−1 (0.1 C) and 50 mAh g−1 (0.5 C) after 1st and 500th cycles.
Separation and Purification of Vanillin and Syringaldehyde from an Oxidized Kraft Liquor – A Mini Review
Authors: Tarigan Meilia Yoseba , Ebrahimi Mehrdad 
Published: March 2024

AbstractLignin is one of the most abundant bio‐aromatic molecular resources, but it is currently underutilized for energy production in the pulp and paper industry. Unlocking the full potential of lignin could have a significant impact on reducing environmental pollution, increasing the use of renewable resources, and achieving environmentally beneficial economic growth. However, effective lignin valorization requires viable and integrated reaction and separation processes to produce high value monomeric phenolics, such as vanillin and syringaldehyde. The aim of this short review is to summarize the studies on different separation methods of lignin derivatives obtained from black liquor, including extraction, membrane filtration, chromatographic separation, and the combination technologies.
Blockchain assisted blind signature algorithm with data integrity verification scheme
Authors: Shrivastava Pranav , Alam Bashir , Alam Mansaf 
Published: March 2024

SummaryAs the demand for cloud storage systems increases, ensuring the security and integrity of cloud data becomes a challenge. Data uploaded to cloud systems are vulnerable to numerous sorts of assaults, which must be handled appropriately to avoid data tampering issues. In addition, quantum computers are expected to be introduced soon, which may face multiple security issues by destroying all traditional cryptosystems. This work introduces a quantum‐resistant blockchain centered data integrity verification system with the use of several techniques. Initially, the keys and signatures are generated by the users with the help of the lattice‐based blind signature algorithm (L_BSA), which is a combination of lattice cryptography and a blind signature algorithm. From the generated random keys, the most optimal key is then selected by the Puzzle Optimization Algorithm (POA), which is then made available to the encryption phase. Then, the upgraded Merkle tree‐assisted vacuum filter (Vac‐UMT) algorithm is executed to accomplish the encryption task. Then the data are converted into blocks using blockchain technology and uploaded to the cloud. When receiving the audit requests, the verification process is carried out, and the evidence report is generated for the users. The proposed work is simulated in JAVA and assessed with the UNSW‐NB15 dataset, and the outcomes demonstrated that the system is highly efficient and secure.
Actuating droplets with electrowetting: Force and dynamics
Authors: Hennig Robert , Cacucciolo Vito , Shea Herbert 
Published: March 2024

AbstractElectrowetting on dielectric (EWOD) allows rapid movement of liquid droplets on a smooth surface, with applications ranging from lab‐on‐chip devices to micro‐actuators. The in‐plane force on a droplet is a key indicator of EWOD performance. This force has been extensively modeled but few direct experimental measurements are reported. We study the EWOD force on a droplet using two setups that allow, for the first time, the simultaneous measurement of force and contact angle, while imaging the droplet shape at 6000 frames/s. For several liquids and surfaces, we observe that the force saturates at a voltage of approximately 150 V. Application of voltages of up 2 kV, that is, 10 times higher than is typical, does not significantly increase forces beyond the saturation point. However, we observe that the transient dynamics, localized at the front contact line, do not show saturation with voltage. At the higher voltages, the initial front contact line speed continues to increase, the front contact angle temporarily becomes near zero, creating a thin liquid film, and capillary waves form at the liquid–air interface. When the localized EWOD forces at the contact line exceed the capillary forces, projectile droplets form. Increasing surface tension allows for higher droplet forces, which we demonstrate with mercury.
An interspecific foraging association with polar bears increases foraging opportunities for avian predators in a declining Arctic seabird colony
Authors: Barnas Andrew F. , Simone Cassandra A. B. , Geldart Erica A. , Love Oliver P. , Jagielski Patrick M. , Gilchrist H. Grant , Richardson Evan S. , Dey Cody J. , Semeniuk Christina A. D. 
Published: March 2024

AbstractInterspecific foraging associations (IFAs) are biological interactions where two or more species forage in association with each other. Climate‐induced reductions in Arctic sea ice have increased polar bear (Ursus maritimus) foraging in seabird colonies, which creates foraging opportunities for avian predators. We used drone video of bears foraging within a common eider (Somateria mollissima) colony on East Bay Island (Nunavut, Canada) in 2017 to investigate herring gull (Larus argentatus) foraging in association with bears. We recorded nest visitation by gulls followingn = 193 eider flushing events from nests during incubation. The probability of gulls visiting eider nests increased with higher number of gulls present (β = 0.14 ± 0.03 [SE],p < .001) and for nests previously visited by a bear (β = 1.14 ± 0.49 [SE],p < .02). In our model examining the probability of gulls consuming eggs from nests, we failed to detect statistically significant effects for the number of gulls present (β = 0.09 ± 0.05 [SE],p < .07) or for nests previously visited by a bear (β = −0.92 ± 0.71 [SE],p < .19). Gulls preferred to visit nests behind bears (χ2 = 18, df = 1,p < .0001), indicating gulls are risk averse in the presence of polar bears. Our study provides novel insights on an Arctic IFA, and we present evidence that gulls capitalize on nests made available due to disturbance associated with foraging bears, as eiders disturbed off their nest allow gulls easier access to eggs. We suggest the IFA between gulls and polar bears is parasitic, as gulls are consuming terrestrial resources which would have eventually been consumed by bears. This finding has implications for estimating the energetic contribution of bird eggs to polar bear summer diets in that the total number of available clutches to consume may be reduced due to avian predators.
A renewed glance at the Palearctic golden eagle: Genetic variation in space and time
Authors: Karabanina Ekaterina , Lansink Gerhardus M. J. , Ponnikas Suvi , Kvist Laura 
Published: March 2024

AbstractAnthropogenic pressures on nature have been causing population declines for centuries. Intensified persecution of apex predators, like the golden eagle, resulted in population bottlenecks during the 19th and 20th centuries. To study population genetics and demographic history of the golden eagle throughout its distribution, we collected museum samples from previously underrepresented regions, such as Russia and Central Asia. We used 12 microsatellite loci and a fragment of the mitochondrial DNA control region to re‐evaluate phylogeography of Eurasian golden eagles and study the impacts of the population bottleneck. Our results revealed a north–south genetic gradient, expressed by the difference between Mediterranean and Holarctic lineages, as well as genetically distinct Northern Europe and Central Asia and Caucasus regions. Furthermore, Northern Europe exhibited the lowest, whereas Central Asia and Caucasus had the highest genetic diversity. Although golden eagles maintained relatively high genetic diversity, we detected genetic signatures of the recent bottleneck, including reduced genetic diversity and a decline in the effective female population size around the year 1975. Our study improves the knowledge of the genetic composition of Eurasian golden eagles and highlights the importance of understanding their historical population dynamics in the face of ongoing and future conservation efforts.
Acquired immune resistance is associated with interferon signature and modulation of KLF6/c‐MYB transcription factors in myeloid leukemia
Authors: Parveen Mubaida , Karaosmanoglu Beren , Sucularli Ceren , Uner Aysegul , Taskiran Ekim Z. , Esendagli Gunes 
Published: March 2024

AbstractResistance to immunity is associated with the selection of cancer cells with superior capacities to survive inflammatory reactions. Here, we tailored an ex vivo immune selection model for acute myeloid leukemia (AML) and isolated the residual subpopulations as “immune‐experienced” AML (ieAML) cells. We confirmed that upon surviving the immune reactions, the malignant blasts frequently decelerated proliferation, displayed features of myeloid differentiation and activation, and lost immunogenicity. Transcriptomic analyses revealed a limited number of commonly altered pathways and differentially expressed genes in all ieAML cells derived from distinct parental cell lines. Molecular signatures predominantly associated with interferon and inflammatory cytokine signaling were enriched in the AML cells resisting the T‐cell‐mediated immune reactions. Moreover, the expression and nuclear localization of the transcription factors c‐MYB and KLF6 were noted as the putative markers for immune resistance and identified in subpopulations of AML blasts in the patients’ bone marrow aspirates. The immune modulatory capacities of ieAML cells lasted for a restricted period when the immune selection pressure was omitted. In conclusion, myeloid leukemia cells harbor subpopulations that can adapt to the harsh conditions established by immune reactions, and a previous “immune experience” is marked with IFN signature and may pave the way for susceptibility to immune intervention therapies.
cis‐Linked Cyclotetraphenylenes: Synthesis, Structures and Fluorescence Properties
Authors: Zou Bo , Li Jian‐An , Zhai Zhaofen , Yu Taoxing , Liu Haoran , Huang Jieqing , He Huowang , Xu Bingjia , Jiang Hua‐Wei 
Published: March 2024

Abstractcis‐Linked cyclotetraphenylene dimer [2]c‐CTPE and trimer [3]c‐CTPE were synthesized via Pt‐mediated cyclization of cis‐diboronated tetraphenylethene. The structure of [2]c‐CTPE has been confirmed by single crystal X‐ray diffraction. The strain energy of [2]c‐CTPE and [3]c‐CTPE was calculated to be 86.28 ⋅ kJ mol−1 and 9.23 kJ ⋅ mol−1, respectively. [2]c‐CTPE and [3]c‐CTPE are typical AIEgens and show mechanofluorochromic properties. The comparisons of cis‐linked cyclotetraphenylenes with gem‐linked cyclotetraphenylenes were also discussed.
Patient and clinician perspectives on supported mealtimes as part of anorexia nervosa treatment: A systematic review and qualitative synthesis
Authors: Komarova Daria , Chambers Kate , Foye Una , Jewell Tom 
Published: March 2024

AbstractObjectiveTo systematically review the literature on clinicians' and patients' experiences of supported mealtimes in the treatment of anorexia nervosa.MethodThis systematic review was conducted in accordance with PRISMA guidelines and registered on PROSPERO (CRD42022372565). PsycINFO, MEDLINE and Embase were searched up to the 20th of November 2023 for qualitative articles investigating the perspectives of healthcare professionals and patients on clinician‐supported meals across all clinical settings. Data were analysed using thematic synthesis. The Critical Appraisal Skills Programme was used to evaluate the quality of selected studies.ResultsThis review comprised of 26 studies; eight concerned with the perspectives of clinicians only, 16 addressing patients' views, and two studies exploring the views of both groups. Experiences of both groups were generally negative, and three overlapping themes were identified: lack of consistency in care provided, high levels of negative emotions and an uncomfortable power dynamic.ConclusionsThis review suggests that supported mealtimes are experienced more positively by patients when rules are clear and consistently enforced, and when clinicians make informal conversation and supportive comments. Our findings highlight the need for best practice guidelines and clinician training to improve the delivery of supported mealtimes. Such guidelines and training should be coproduced in collaboration with patients and carers.