bluuebunny/crossref_metadata_2025_split huggingface dataset:
Amniotic Fluid Proteomics Analysis and In Vitro Validation to Identify Potential Biomarkers of Preterm Birth
Authors: Chen Siguo , Wang Weizhou , Yan Guanghong , Liu Mengmei , Li Min , Chen Ping , Ma Qingyan , Zhang Jinman , Tang Ying , Zhou Linglin , You Dingyun 
Published: March 2024

AbstractThis study aimed to investigate the regulation of amniotic fibroblast (AFC) function by vitamin K–dependent protein Z (PROZ) during preterm birth (PTB) and its potential role in adverse pregnancy outcomes. Proteomic samples were collected from amniotic fluid in the second trimester, and AFC were isolated from the amniotic membrane and cultured in vitro. The expression of extracellular and intracellular PROZ in AFC was modulated, and their biological properties and functions were evaluated. Clinical analysis revealed a significant upregulation of PROZ expression in amniotic fluid from preterm pregnant women. In vitro experiments demonstrated that PROZ stimulated AFC migration, enhanced their proliferative capacity, and reduced collagen secretion. Overexpression of PROZ further enhanced cell migration and proliferation, while knockdown of PROZ had the opposite effect. PROZ plays a crucial role in promoting the proliferation and migration of amniotic membrane fibroblasts. Increased PROZ expression in amniotic fluid is associated with the occurrence of PTB. These findings shed light on the potential involvement of PROZ in adverse pregnancy outcomes and provide a basis for further research on its regulatory mechanisms during PTB.
Optimal urban sustainable design for residential village in Al-Baha region: application five roles strategies
Authors: Aldossary Naief A. 
Published: March 2024

AbstractThis paper evaluates and discusses the proposed design for a low carbon environmental village in Al-Baha region. It considers its viability in view of local renewable energy sources, climatic conditions and local vernacular architectural identity. Five areas were targeted when designing the village: (a) low carbon architectural design strategies; (b) on-site renewable energy strategies; (c) selection of local construction materials; (d) exploitation of rain water harvesting and greywater recycling; and (e) waste disposal recycling and management. The used approach is to design a sustainable village with its facilities in prospective of environmental requirements social needs. The design follow application five roles’ strategies from the literature and depending on local site challenges, available of natural in a location of Al-Baha gate from the airport. The site selected is located along the main highway that connects Al-Baha city to its nearest airport. The chosen area is 4,945,000 m2 and has a flat topography with mountains located relatively close by. The findings present in the study plans for comprehensive sustainable low carbon energy village, which meet the climatic requirements and exploiting natural resources operated by natural renewable energy. This village is designed for typical Saudi families, and will be built from local construction materials. The design includes more than 6150 residential units powered by photovoltaic (PV) panels, and local services using wind energy. The energy requirements for the whole village were calculated based on macro and micro energy generation. Local regulatory standards and sustainability criteria have also been met for the proposed village. Five experts also evaluated the five-purpose design proposition. The impact of designing sustainable villages will lead in protection of environment improved the life and health quality as well as economic benefits. The benefits of addressing five aims are highlighted and the study concluded with some recommendations.
Exploring the Nexus: Gaseous Micro-embolic Activity and Pressure Drop on ALONE ECMO Oxygenator
Authors: Condello Ignazio 
Published: March 2024

Abstract
The role of inlet and outlet oxygenator pressure know as pressure drop (ΔP) in the elimination of the gaseous micro-emboli activity (GMEA) remains obscured during Extracorporeal Membrane Oxygenation (ECMO) and Minimally Invasive Extracorporeal Circulation (MiECC). There is conflicting literature on the role of pressure drop in oxygenators as well as on oxygenating performance, fluid dynamics and in the role of gaseous micro-embolic activity elimination. We analyzed 14 procedures, 10 MiECC with polypropylene fibers ALONE AF oxygenator and 4 ECMO with polymethylpentene Alone ECMO Oxygenator (Eurosets, SRL, Medolla,Italy), in the central and peripheral cannulation configuration, respectively, through the use of GAMPT BCC300 for air gas micro-emboli (GME) in relation to the ΔP of Oxygenator and incidence of cavitation. The groups of MiECC, Central Cannulation VS Peripheral Cannulation reported: mean values for cavitation n° of bubbles was 330 ± 12 vs 80 ± 13; 1.5 vs 0% reported a diameter > 500 μm; GME volume was 1.51 ± 0.2 vs 0.121 ± 0.2 (μL) in the arterial line, the mean ΔP of oxygenator reported was 89 ± 11 vs 130 ± 29 mmHg. The groups of ECMO, Central Cannulation VS Peripheral Cannulation reported: mean values for cavitation n° of bubbles was 470 ± 12 vs 140 ± 17; 2.1 vs 0% reported a diameter > 500 μm; GME volume was 2.5 ± 0.5 vs 0.355 ± 0.7 (μL) in the arterial line, the mean ΔP of oxygenator reported was 88 ± 15vs 150 ± 23 mmHg. In this report, patients with low pressure drop in the oxygenator reported a statistically significant increase in GMEA in the arterial line of the circuit for each cavitation phenomenon, compared to the group with high pressure drop in the oxygenator who reported a reduced GMEA. In this report, oxygenators with higher pressure drops demonstrated a significant reduction of GMEA, however, further studies are needed to confirm these results.
Cognitive changes after tap test in patients with normal pressure hydrocephalus: a before-and-after study
Authors: Mayorga Pilar , Hurtado Cethinia , Gempeler Andrés , Cruz-Sanabria Francy , González Martina , Jaramillo Daniel , Mejía-Michelsen Isabella , Ramón Juan Fernando , Gomez-Amarillo Diego Fernando , Hakim Fernando 
Published: March 2024

AbstractNormal pressure hydrocephalus (NPH) leads to cognitive impairment (CI) as part of its triad of symptoms. Assessment of CI before and after a tap test can be used to inform diagnosis, differentiate NPH symptoms from alternative or concomitant causes of CI, and suggest the potential benefits of valve placement. The aims of this study are: to describe cognitive performance in patients with NPH diagnosis before and after a tap test, and to compare CI between patients with NPH meeting criteria for a dementia diagnosis (D +) and those without criteria for dementia (D−) at both baseline and after the tap-test. We performed a Before-and-after study evaluating clinical features and performance on cognitive tests (CERAD, ADAS-COG, SVF, PVF, ROCF and IFS). We included 76 NPH patients, with a median age of 81 years. 65 patients (87.8%) improved cognitive performance after tap test. ROCF (p = 0.018) and IFS (p < 0.001) scores significantly change after the tap test. Dementia was concomitant in 68.4% of patients. D + group showed higher proportion of patients with altered performance in IFS, PVF, SVF, and ROCF than D- group at baseline (p < 0.05). A significant improvement in SVF and IFS was observed exclusively in the D− group after tap test. Our results suggest that executive function and praxis are the cognitive domains more susceptible to improvement after a tap test in a 24-h interval in NPH patients. Moreover, the D− group showed a higher proportion of improvement after the tap test in executive function and verbal fluency test compared with the D + group.
Tracking Mississippian Migrations from the Central Mississippi Valley to the Ridge and Valley with a Unified Absolute Chronology
Authors: Sullivan Lynne P. , Smith Kevin E. , Meeks Scott C. , Patch Shawn M. 
Published: March 2024

AbstractAs regional chronologies become better defined, we are better able to track large-scale population movements and related cultural change. A dataset of 156 radiocarbon dates from the Middle Cumberland Region (MCR), evaluated with 199 more dates from the Ridge and Valley portions of northern Georgia and East Tennessee, enable modeling of population movements from the Central Mississippi Valley into the MCR, as well as subsequent movements and effects in the Ridge and Valley between AD 1200 and 1450. The dissolution of Cahokia is of particular interest, because the MCR falls geographically between the American Bottom and the Ridge and Valley province. This large-scale chronological perspective places key events in this part of the Southeast and Midwest into a unified historical framework that increases our understanding of the timing of cultural events. A related goal is to sort out possible external events and influences that may have affected this large region. This study makes apparent the relationships between cultural events and natural events, such as the drought sequences reported for the Central Mississippi Valley and beyond.
Advancing assessment of responsive feeding environments and practices in child care
Authors: Campbell Julie E. , McIsaac Jessie-Lee D. , Young Margaret , Dickson Elizabeth , Caldwell Sarah , Barich Rachel , Rossiter Misty 
Published: March 2024

Abstract
Child care environments offer an ideal setting for feeding interventions. CELEBRATE Feeding is an approach implemented in child care environments in two Maritime Provinces in Canada to support responsive feeding (RF) to foster children’s self-efficacy, self-regulation, and healthy relationships with food. This study aimed to describe RF in child care using established and enhanced scoring frameworks.
The Environment and Policy Assessment and Observation (EPAO) was modified to reflect RF environments and practices, resulting in our modified EPAO and a CELEBRATE scale. Observations were conducted in 18 child care rooms. Behaviours and environments were scored on both scales, creating 21 RF scores, with a score of ‘3’ indicating the most responsiveness. Descriptive analyses of the scores were conducted. The overall room averages were Mean (M) = 41.00, Standard Deviation (SD) = 7.07 (EPAO), and M = 37.92 SD = 6.50 (CELEBRATE). Most responsive scores among rooms within our EPAO and CELEBRATE scales, respectively, were ‘educators not using food to calm or encourage behaviour’ (M = 2.94, SD = 0.24; M = 2.98, SD = 0.06) and ‘not requiring children to sit at the table until finished’ (M = 2.89, SD = 0.47; M = 2.97, SD = 0.12). The least responsive scores within the EPAO were ‘educator prompts for children to drink water’ (M = 0.78, SD = 0.94) and ‘children self-serving’ (M = 0.83, SD = 0.38). The least responsive in the CELEBRATE scale were ‘enthusiastic role modelling during mealtime’ (M = 0.70, SD = 0.68) and ‘praise of mealtime behaviour unrelated to food intake’ (M = 0.74, SD = 0.55). The CELEBRATE scale captured unique observation information about RF to allow documenting change over time with detailed measurement to inform and support nutrition interventions within child care environments.
A Chronological Model for Inca Provincial Expansion: The Case of the Copiapo Valley
Authors: Garrido Francisco 
Published: March 2024

AbstractThis article examines a new dataset of radiocarbon dates that provides insights into the progressive installation of Inca infrastructure in the Copiapo Valley, situated at the southern edge of the Atacama Desert in northern Chile. It shows that the Inca imperial expansion in this region was not a linear process and was likely shaped by local negotiations and conflicts. The findings describe three main stages of Inca expansion. The first is the construction of the North–South Inca Road and the establishment of high-altitude mountain shrines. The next stage consisted of a physical intervention in a local village located in the upper valley, including the construction of administrative buildings and public spaces. The last stage involved indirect intervention in local villages, characterized by the presence of isolated administrative buildings that were potentially used for diplomacy and negotiation. I argue that the Inca imperial expansion, characterized by evolving strategies across regions and time periods, not only demonstrates the state's capacity for learning but also suggests the pivotal role of local actors in positions of power who wielded agency to shape these developments.
Obsidian Procurement and Exchange at the Apogee of Empire: Wari Political Economy in Arequipa, Peru
Authors: Reid David A. , Williams Patrick Ryan , Cardona Rosas Augusto , Goldstein Robin Coleman , Dussubieux Laure , Banikazemi Cyrus , Rademaker Kurt 
Published: March 2024

AbstractDuring the Middle Horizon (AD 600–1000), obsidian was transported in greater quantities and distances than ever before identified in the Andes, in part by the expansionary Wari state. Two of the three major obsidian sources used in the south-central Andes are located in the modern department of Arequipa, Peru. Arequipa was a region of intense Wari influence and intrusive presence; however, little is known about regional obsidian use. Portable X-ray fluorescence (pXRF) and laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) were used to analyze 383 obsidian artifacts recovered from 10 archaeological sites in Arequipa. Results highlight diachronic and spatial patterning related to obsidian procurement strategies, state versus bottom-up exchange networks, and local participation within the Wari realm. A wide variety of geological obsidian sources, including nonlocal obsidians originating from Wari's Ayacucho heartland, were used. By the late Middle Horizon, the Wari had consolidated regional resources with the sole use of Alca-1 and Alca-4 bedrock obsidians, the largest-sized and highest-quality sources in the area. We assess related models of obsidian procurement and exchange related to state political economy, long-distance caravan activity, and the role of local ceremonial/waystation centers that facilitated the flow of ideas, goods, and people across Arequipa.
Against Latin American Regionalisms: The 1927 Brussels Congress and the Anti-Imperialist League of the Americas
Authors: Mahler Anne Garland 
Published: March 2024

AbstractThis article examines the encounter of activists from the Anti-Imperialist League of the Americas (LADLA) with African, African American, and Asian anticolonial intellectuals through the League Against Imperialism (LAI), founded at the 1927 Brussels Congress. Drawing from LADLA’s newspaperEl Libertador, letters from LADLA leaders, and speeches and resolutions in the LAI archive, it studies how exchanges begun in Brussels influenced debates in radical circles in the Americas. The article builds on extant scholarship and makes two primary interventions. First, it argues that a closer look at LADLA’s participation in the LAI shifts the traditional understanding of interwar Latin American regionalist ideologies, which LADLA rejected in favor of drawing connections to anti-imperialist movements around the world. Second, it argues that the exchange in Brussels influenced LADLA to eventually expand its initial focus on Indigenous struggles to think more critically about Black communities, including Black migrant labor, in political organizing.
The Southwest Silk Road: artistic exchange and transmission in early China
Authors: Elias Hajni 
Published: March 2024

AbstractIn examining wares discovered from the cultures of Sanxingdui and Jinsha and from the former site of the ancient kingdom of Dian in Sichuan and Yunnan provinces, this article highlights a number of shared features and trends that suggest a continued artistic, technological and cultural transmission through time and space. The article aims to supplement established theories on the rich material culture of this region. It will look in particular at the development of its striking bronze metallurgy, largely deriving from the established traditions of the Yellow River valley in China’s Bronze Age. It highlights the function of a dense network of trading routes, referred to in modern scholarship as the “Southwest Silk Road”, as an important facilitator of cultural and artistic exchange and reciprocation from ancient times.
Non-Archimedean population axiologies
Authors: Baker Calvin 
Published: March 2024

AbstractNon-Archimedean population axiologies – also known as lexical views – claim (i) that a sufficient number of lives at a very high positive welfare level would be better than any number of lives at a very low positive welfare level and/or (ii) that a sufficient number of lives at a very low negative welfare level would be worse than any number of lives at a very high negative welfare level. Such axiologies are popular because they can avoid the (Negative) Repugnant Conclusion and satisfy the adequacy conditions given in the central impossibility result in population axiology due to Gustaf Arrhenius. I provide a novel argument against them which appeals to the way that good and bad lives can intuitively outweigh one another.
How to solve a binary cubic equation in integers
Authors: MASSER DAVID 
Published: March 2024

AbstractGiven any polynomial in two variables of degree at most three with rational integer coefficients, we obtain a new search bound to decide effectively if it has a zero with rational integer coefficients. On the way we encounter a natural problem of estimating singular points. We solve it using elementary invariant theory but an optimal solution would seem to be far from easy even using the full power of the standard Height Machine.
Care burden and support needs of caregivers of infants and children with CHDs and dysphagia
Authors: Norman Vivienne , Zühlke Liesl , Morrow Brenda 
Published: March 2024

AbstractDysphagia is common in children with CHDs, resulting in multiple stressors for their caregivers including having a child with a serious medical condition and coping with their child’s feeding needs. However, relatively little is known about caregivers’ perceptions and experiences of the burden of care and support needs for their child with a CHD and dysphagia in low-middle income contexts. This qualitative study investigated the burden of care and support needs identified by parents of children with CHDs and dysphagia in a single centre in South Africa. Semi-structured interviews took place in a tertiary hospital with seven mothers of children with CHDs and dysphagia, followed by content analysis. Participants described four main impacts of their child’s condition, which included worry, the burden of caregiving, emotional responses, and acceptance and coping. The participants were well-supported by speech-language therapists and dieticians, but suggestions for additional support included support groups and using mobile messaging apps for communication with peers and professionals. The study has important implications for understanding challenges faced by caregivers of children with complex needs in low-middle income settings and will be useful to inform and improve holistic healthcare practice for families of children with CHDs and dysphagia.
Evaluation of handgrip strength in children with pulmonary hypertension
Authors: Kavgacı Akif , Kula Serdar , Berber Maraşlı Elif , Zinnuroğlu Murat , Çelik Bülent , Terlemez Semiha , Tunaoğlu Sedef , Oğuz Deniz 
Published: March 2024

AbstractBackground:Handgrip strength is a crucial indicator of upper extremity muscular strength and is vital for monitoring disorders like cardiac diseases that restrict a patient’s physical activity and result in muscle atrophy. The aim of our study was to evaluate whether muscle strength loss is present in patients with pulmonary hypertension and whether this test can be an alternative to 6-minute walk test.Materials and methods:The study included 39 healthy children who were admitted to the outpatient clinic and 16 children with a diagnosis of pulmonary hypertension who were being followed in our centre. We assessed the differences in upper extremity handgrip strength using the Jamar Hydraulic Hand Dynamometer device among both healthy children and those diagnosed with pulmonary hypertension. Moreover, we compared the handgrip strength of pulmonary hypertension patients with significant prognostic indicators such as NYHA class, 6-minute walk test, and pro-brain natriuretic peptide.Results:The mean dominant handgrip strength was 20.8 ± 12 kg in the patient group and 21.6 ± 12.4 kg in the control group (p = 0.970). Handgrip strength was shown to be negatively connected with pro-brain natriuretic peptide (r = −0.565, p = 0.023) and positively correlated with 6-minute walk test (r = 0.586, p = 0.022) during the patient group evaluation.Conclusion:Six-minute walk test needs a customised physical area (30 m of a straight hallway) and trained personnel for applying the test. The handgrip strength test, a different muscle strength indicator, can be used to more clearly and simply indicate the decline in patients’ ability for effort. Additionally, it was found in our study that handgrip strength decreased as pro-brain natriuretic peptide levels rose, a crucial measure in the monitoring of pulmonary hypertension.
The interaction of central and peripheral processing in L2 handwritten production: Evidence from cross-linguistic variations
Authors: Fu Yang , Álvarez Carlos J. , Bermúdez-Margaretto Beatriz , Afonso Olivia , Wang Huili , Domínguez Alberto 
Published: March 2024

Abstract
The current study explores the interplay between central and peripheral processes in second language (L2) handwriting among bilinguals with diverse orthographic backgrounds. Our investigation delves into the cross-linguistic transfer effect in Spanish–English and Chinese–English bilinguals, emphasizing lexical frequency and phoneme-grapheme (P-O) consistency in spelling-to-dictation and immediate copying tasks. Results reveal that the interaction between central and peripheral processes in L2 handwritten production is shaped by the bilinguals' native language (L1) orthographic characteristics. Spanish–English bilinguals exhibited sensitivity to P-O consistency and the spread of this effect from central to peripheral processes throughout both tasks. Conversely, Chinese–English bilinguals showed heightened sensitivity to lexical frequency during orthographic planning and motor execution, particularly in the immediate copying task. In a broader context, these findings suggest that the parallel and cascading coordination of the L2 writing system is modulated by cross-linguistic variations. The implications of our findings hold relevance for handwriting production and bilingualism research.