bluuebunny/crossref_metadata_2025_split huggingface dataset:
Plasma biomarkers for predicting the development of dementia in a community‐dwelling older Japanese population
Authors: Ohara Tomoyuki , Tatebe Harutsugu , Hata Jun , Honda Takanori , Shibata Mao , Matsuura Sayo , Mikami Tatsuya , Maeda Tetsuya , Ono Kenjiro , Mimura Masaru , Nakashima Kenji , Iga Jun‐ichi , Takebayashi Minoru , Tokuda Takahiko , Ninomiya Toshiharu ,   JPSC‐AD (Japan Prospective Studies Collaboration for Aging and Dementia) study group
Published: April 2024

AimTo assess the association between plasma amyloid β (Aβ) 42/40, phosphorylated tau (p‐τ)181, glial fibrillary acidic protein (GFAP), or neurofilament light chain (NfL) and the risk of dementia and to determine whether these plasma biomarkers could improve the ability to predict incident dementia in a general older population.MethodsA total of 1346 Japanese community‐dwelling individuals aged ≥65 years without dementia were followed prospectively for 5.0 years. Plasma biomarkers were quantified using a Simoa HD‐X analyzer. A Cox proportional hazards model was used to estimate the hazard ratios of each plasma biomarker level for the risk of dementia.ResultsDuring the follow‐up, 151 participants developed dementia, of whom 108 had Alzheimer disease (AD) and 43 non–Alzheimer dementia (non‐AD). Lower plasma Aβ42/40 levels and higher plasma p‐τ181 levels were significantly associated with developing AD but not non‐AD, whereas significant associations were observed between higher plasma levels of GFAP and NfL and risk of both AD and non‐AD (all P for trend <0.05). In addition, adding these four plasma biomarkers into a model consisting of the total score of the dementia risk model significantly improved the predictive ability for incident dementia.ConclusionOur findings suggest that plasma Aβ42/40 and p‐τ181 are specific markers of AD, and plasma GFAP and NfL are potential biomarkers for all‐cause dementia in the general Japanese older population. In addition, the measurement of these plasma biomarkers may be a useful and relatively low‐invasive procedure for identifying individuals at high risk for developing dementia in clinical practice.
Recombinant human proteoglycan 4 lowers inflammation and atherosclerosis susceptibility in female low‐density lipoprotein receptor knockout mice
Authors: Hoekstra Menno , Snip Olga S. C. , Janusz Philip , Bernabé Kleijn Mireia N. A. , Truitt Edward R. , Sullivan Benjamin D. , Schmidt Tannin A. , Jay Gregory D. , Van Eck Miranda 
Published: April 2024

AbstractRecombinant human proteoglycan 4 (rhPRG4) is a macromolecular mucin‐like glycoprotein that is classically studied as a lubricant within eyes and joints. Given that endogenously produced PRG4 is present within atherosclerotic lesions and genetic PRG4 deficiency increases atherosclerosis susceptibility in mice, in the current study we investigated the anti‐atherogenic potential of chronic rhPRG4 treatment. Female low‐density lipoprotein receptor knockout mice were fed an atherogenic Western‐type diet for 6 weeks and injected three times per week intraperitoneally with 0.5 mg rhPRG4 or PBS as control. Treatment with rhPRG4 was associated with a small decrease in plasma‐free cholesterol levels, without a change in cholesteryl ester levels. A marked increase in the number of peritoneal foam cells was detected in response to the peritoneal rhPRG4 administration, which could be attributed to elevated peritoneal leukocyte MSR1 expression levels. However, rhPRG4‐treated mice exhibited significantly smaller aortic root lesions of 278 ± 21 × 103 μm2 compared with 339 ± 15 × 103 μm2 in the aortic root of control mice. The overall decreased atherosclerosis susceptibility coincided with a shift in the monocyte and macrophage polarization states towards the patrolling and anti‐inflammatory M2‐like phenotypes, respectively. Furthermore, rhPRG4 treatment significantly reduced macrophage gene expression levels as well as plasma protein levels of the pro‐inflammatory/pro‐atherogenic cytokine TNF‐alpha. In conclusion, we have shown that peritoneal administration and subsequent systemic exposure to rhPRG4 beneficially impacts the inflammatory state and reduces atherosclerosis susceptibility in mice. Our findings highlight that PRG4 is not only a lubricant but also acts as an anti‐inflammatory agent.
imageKey points
Endogenously produced proteoglycan 4 is found in atherosclerotic lesions and its genetic deficiency in mice is associated with enhanced atherosclerosis susceptibility.
In this study we investigated the anti‐atherogenic potential of chronic treatment with recombinant human PRG4 in hypercholesterolaemic female low‐density lipoprotein receptor knockout mice.
We show that recombinant human PRG4 stimulates macrophage foam cell formation, but also dampens the pro‐inflammatory state of monocyte/macrophages, eventually leading to a significant reduction in plasma TNF‐alpha levels and a lowered atherosclerosis susceptibility.
Our findings highlight that peritoneal recombinant human PRG4 treatment can execute effects both locally and systemically and suggest that it will be of interest to study whether rhPRG4 treatment is also able to inhibit the progression and/or induce regression of previously established atherosclerotic lesions.
Multi-Ingredient Preworkout Supplementation Compared With Caffeine and a Placebo Does Not Improve Repetitions to Failure in Resistance-Trained Women
Authors: Snyder Mariah , Brewer Christi , Taylor Katrina 
Published: April 2024

There has been an increase in the use of commercially available multi-ingredient preworkout supplements (MIPS); however, there are inconsistencies regarding the efficacy of MIPS in resistance-trained women. Purpose: To determine the effect of varying doses of MIPS compared with caffeine only (C) and a placebo (PL) on resistance-training performance in trained women. Methods: Ten women (21.5 [2.3] y) completed 1-repetition-maximum tests at baseline for leg press and bench press. A within-group, double-blind, and randomized design was used to assign supplement drinks (ie, PL, C, MIPS half scoop [MIPS-H], and MIPS full scoop [MIPS-F]). Repetitions to failure were assessed at 75% and 80% to 85% of 1-repetition maximum for bench and leg press, respectively. Total performance volume was calculated as load × sets × repetitions for each session. Data were analyzed using a 1-way repeated-measures analysis of variance and reported as means and SDs. Results: There were no differences in repetitions to failure for bench press (PL: 14.4 [3.2] repetitions, C: 14.4 [2.9] repetitions, MIPS-H: 14.2 [2.6] repetitions, MIPS-F: 15.1 [3.1] repetitions; P = .54) or leg press (PL: 13.9 [7.8] repetitions, C: 10.8 [5.9] repetitions, MIPS-H: 13.1 [7.1] repetitions, MIPS-F: 12.4 [10.7] repetitions; P = .44). Furthermore, there were no differences in total performance volume across supplements for bench press (PL: 911.2 [212.8] kg, C: 910.7 [205.5] kg, MIPS-H: 913.6 [249.3] kg, MIPS-F: 951.6 [289.6] kg; P = .39) or leg press (PL: 4318.4 [1633.6] kg, C: 3730.0 [1032.5] kg, MIPS-H: 4223.0 [1630.0] kg, MIPS-F: 4085.5 [2098.3] kg; P = .34). Conclusions: Overall, our findings suggest that caffeine and MIPS do not provide ergogenic benefits for resistance-trained women in delaying muscular failure.
Managing Challenging Situations in the Coach–Athlete Dyad: Introducing the Grey Zone Model From the Coach Perspective
Authors: Slade Katelynn , Jowett Sophia , Rhind Daniel 
Published: April 2024

Challenging situations and interactions are necessary and unavoidable in sport. From deselection to injury, burnout, and mental health issues, coaches and athletes will face challenging situations throughout their sporting career. The aims of this research study were to (a) introduce a conceptual model of challenging situations and subsequently to (b) explore a range of challenging situations that occur in high-performance sport, and (c) discover how such challenging situations are managed and perceived by high-performance coaches. In this study, challenging situations in coach–athlete dyads are defined as organisational, performance, interpersonal, and personal stressors that can push or pull one or both the coach and athlete, and subsequently their relationship into a state of indeterminacy (i.e., the Grey Zone) that may cause stress, strain, conflict, or resolution and understanding depending on how the challenging situations are managed. A total of 11 current high-performance and World Class Performance coaches (M = 41.64 years old, SD = 10.69 years; female = 4, male = 7), took part in a semistructured interview aided by vignettes to explore and discover the process by which coaches deal with challenging situations. Using a pragmatism approach, a content analysis guided by the conceptual Grey Zone Model was utilised to analyse the obtained qualitative data. Results indicated that coaches regularly experience challenging situations and use a variety of techniques to manage them. The Grey Zone Model is proposed as a practical tool to help coaches, athletes, and other practitioners, such as sport psychology consultants and coach developers to analyse the various phases of challenging situations.
Dual molecule targeting HDAC6 leads to intratumoral CD4+ cytotoxic lymphocytes recruitment through MHC-II upregulation on lung cancer cells
Authors: Ducellier Sarah , Demeules Mélanie , Letribot Boris , Gaetani Massimiliano , Michaudel Chloé , Sokol Harry , Hamze Abdallah , Alami Mouad , Nascimento Mégane , Apcher Sébastien 
Published: April 2024

BackgroundDespite the current therapeutic treatments including surgery, chemotherapy, radiotherapy and more recently immunotherapy, the mortality rate of lung cancer stays high. Regarding lung cancer, epigenetic modifications altering cell cycle, angiogenesis and programmed cancer cell death are therapeutic targets to combine with immunotherapy to improve treatment success. In a recent study, we uncovered that a molecule called QAPHA ((E)−3-(5-((2-cyanoquinolin-4-yl)(methyl)amino)−2-methoxyphenyl)-N-hydroxyacrylamide) has a dual function as both a tubulin polymerization and HDAC inhibitors. Here, we investigate the impact of this novel dual inhibitor on the immune response to lung cancer.MethodsTo elucidate the mechanism of action of QAPHA, we conducted a chemical proteomics analysis. Using an in vivo mouse model of lung cancer (TC-1 tumor cells), we assessed the effects of QAPHA on tumor regression. Tumor infiltrating immune cells were characterized by flow cytometry.ResultsIn this study, we first showed that QAPHA effectively inhibited histone deacetylase 6, leading to upregulation of HSP90, cytochrome C and caspases, as revealed by proteomic analysis. We confirmed that QAPHA induces immunogenic cell death (ICD) by expressing calreticulin at cell surface in vitro and demonstrated its efficacy as a vaccine in vivo. Remarkably, even at a low concentration (0.5 mg/kg), QAPHA achieved complete tumor regression in approximately 60% of mice treated intratumorally, establishing a long-lasting anticancer immune response. Additionally, QAPHA treatment promoted the infiltration of M1-polarized macrophages in treated mice, indicating the induction of a pro-inflammatory environment within the tumor. Very interestingly, our findings also revealed that QAPHA upregulated major histocompatibility complex class II (MHC-II) expression on TC-1 tumor cells both in vitro and in vivo, facilitating the recruitment of cytotoxic CD4+T cells (CD4+CTL) expressing CD4+, NKG2D+, CRTAM+, and Perforin+. Finally, we showed that tumor regression strongly correlates to MHC-II expression level on tumor cell and CD4+CTL infiltrate.ConclusionCollectively, our findings shed light on the discovery of a new multitarget inhibitor able to induce ICD and MHC-II upregulation in TC-1 tumor cell. These two processes participate in enhancing a specific CD4+cytotoxic T cell-mediated antitumor response in vivo in our model of lung cancer. This breakthrough suggests the potential of QAPHA as a promising agent for cancer treatment.
Efficient CAR T cell targeting of the CA125 extracellular repeat domain of MUC16
Authors: Casey Nicholas P , Kleinmanns Katrin , Forcados Christopher , Gelebart Pascal F , Joaquina Sandy , Lode Martine , Benard Emmanuelle , Kaveh Fatemeh , Caulier Benjamin , Helgestad Gjerde Christiane , García de Jalón Elvira , Warren David J , Lindemann Kristina , Rokkones Erik , Davidson Ben , Myhre Marit Renee , Kvalheim Gunnar , Bjørge Line , McCormack Emmet , Inderberg Else Marit , Wälchli Sébastien 
Published: April 2024

BackgroundOvarian cancer (OC) is the leading cause of death from gynecologic malignancies in the Western world. Contributing factors include a high frequency of late-stage diagnosis, the development of chemoresistance, and the evasion of host immune responses. Currently, debulking surgery and platinum-based chemotherapy are the treatment cornerstones, although recurrence is common. As the clinical efficacy of immune checkpoint blockade is low, new immunotherapeutic strategies are needed. Chimeric antigen receptor (CAR) T cell therapy empowers patients’ own T cells to fight and eradicate cancer, and has been tested against various targets in OC. A promising candidate is the MUC16 ectodomain. This ectodomain remains on the cell surface after cleavage of cancer antigen 125 (CA125), the domain distal from the membrane, which is currently used as a serum biomarker for OC. CA125 itself has not been tested as a possible CAR target. In this study, we examined the suitability of the CA125 as a target for CAR T cell therapy.MethodsWe tested a series of antibodies raised against the CA125 extracellular repeat domain of MUC16 and adapted them to the CAR format. Comparisons between these candidates, and against an existing CAR targeting the MUC16 ectodomain, identified K101 as having high potency and specificity. The K101CAR was subjected to further biochemical and functional tests, including examination of the effect of soluble CA125 on its activity. Finally, we used cell lines and advanced orthotopic patient-derived xenograft (PDX) models to validate, in vivo, the efficiency of our K101CAR construct.ResultsWe observed a high efficacy of K101CAR T cells against cell lines and patient-derived tumors, in vitro and in vivo. We also demonstrated that K101CAR functionality was not impaired by the soluble antigen. Finally, in direct comparisons, K101CAR, which targets the CA125 extracellular repeat domains, was shown to have similar efficacy to the previously validated 4H11CAR, which targets the MUC16 ectodomain.ConclusionsOur in vitro and in vivo results, including PDX studies, demonstrate that the CA125 domain of MUC16 represents an excellent target for treating MUC16-positive malignancies.
Exact phonon quasibound states around an optical black hole
Authors: Senjaya David 
Published: April 2024

AbstractIn this work, we present an exact solution of phonon quasibound states in a vortex photon flow that creates an analogous black hole background. We worked out and successfully solve the governing differential equation of the systen that is similar with the relativistic Klein–Gordon equation. The exact radial solutions are discovered in terms of the confluent Heun functions that behaves as ingoing waves near the black hole’s horizon and decaying far away from the black hole’s horizon. The polynomial condition of the confluent Heun function leads to the discovery of the the complex valued quantized energy levels expression of the quasibound state of which depends on the phonon mass $$\Omega _0$$

Ω
0

, the photon vortex horizon’s spin $$\Omega _H$$

Ω
H

and the azimuthal and the main quantum number (m, n). In the last section, by using the Damour–Ruffini method, the Hawking radiation of the analog black hole’s horizon is investigated to derive the phononic radiation distribution function from where, the Hawking temberature is obtained.
eZNS: Elastic Zoned Namespace for Enhanced Performance Isolation and Device Utilization
Authors: Min Jaehong , Zhao Chenxingyu , Liu Ming , Krishnamurthy Arvind 
Published: April 2024

Emerging Zoned Namespace (ZNS) SSDs, providing the coarse-grained zone abstraction, hold the potential to significantly enhance the cost efficiency of future storage infrastructure and mitigate performance unpredictability. However, existing ZNS SSDs have a static zoned interface, making them in-adaptable to workload runtime behavior, unscalable to underlying hardware capabilities, and interfering with co-located zones. Applications either under-provision the zone resources yielding unsatisfied throughput, create over-provisioned zones and incur costs, or experience unexpected I/O latencies.We propose eZNS, an elastic-ZNS interface that exposes an adaptive zone with predictable characteristics. eZNS comprises two major components: a zone arbiter that manages zone allocation and active resources on the control plane, and a hierarchical I/O scheduler with read congestion control and write admission control on the data plane. Together, eZNS enables the transparent use of a ZNS SSD and closes the gap between application requirements and zone interface properties. Our evaluations over RocksDB demonstrate that eZNS outperforms a static zoned interface by 17.7% and 80.3% in throughput and tail latency, respectively, at most.
From Detection to Application: Recent Advances in Understanding Scientific Tables and Figures
Authors: Huang Jiani , Chen Haihua , Yu Fengchang , Lu Wei 
Published: April 2024

Tables and figures are usually used to present information in a structured and visual way in scientific documents. Understanding the tables and figures in scientific documents is significant for a series of downstream tasks, such as academic search, scientific knowledge graphs, and so on. Existing studies mainly focus on detecting figures and tables from scientific documents, interpreting their semantics, and integrating them into downstream tasks. However, a systematic and comprehensive literature review on the mining and application of tables and figures in academic papers is still missing. In this article, we introduce the research framework and the whole pipeline for understanding tables and figures, including detection, structural analysis, interpretation, and application. We deliver a thorough analysis of benchmark datasets, recent techniques, and their pros and cons. Additionally, a quantitative analysis of the effectiveness of different models on popular benchmarks is presented. We further outline several important applications that exploit the semantics of scientific tables and figures. Finally, we highlight the challenges and some potential directions for future research. We believe this is the first comprehensive survey in understanding scientific tables and figures that covers the landscape from detection to application.
What Matisse and Picasso Owed to Jewish Collectors and Dealers
Authors: Silver Larry 
Published: April 2024

Abstract
While the prominence in twentieth-century painting of Henri Matisse and Pablo Picasso remains unquestioned, neither of these great artists could have emerged in their shared Parisian art world without the direct support of Jewish collectors and dealers. Foremost among the Jewish collectors of their earlier works were Americans living in Paris, especially the Steins: Leo, Gertrude, and Michael and Sarah Stein. While Leo followed by Michael and Sarah was an early purchaser of Matisse’s bold early Fauvist works, led by Bonheur de Vie (1905), Gertrude turned increasingly to Picasso, who painted her portrait (1906). Their support for Matisse was avidly seconded by the Cone sisters, whose extensive collection was donated intact to the Baltimore Museum of Art. Jews were also early adopters of French modern art in general as dealers. Chiefly led by the Rosenberg brothers, Léonce and Paul, prominent Jewish dealers during the teens also included the perceptive, if underfunded, Berthe Weill as well as the German immigrant Daniel-Henry Kahnweiler. Both of the latter gave crucial support to experimental art, the latter in particular to the art of Picasso’s Cubist phase (including a Cubist portrait of the dealer). In addition, a number of Jewish art critics served as influencers, supporting contemporary artists, albeit often castigating paintings by immigrant Eastern European Jewish artists, whom they viewed as outsiders. In their view, it was the multinational School of Paris’ often Jewish immigrants, against the greater, local School of France.
“Old Frantic Fingers”
Authors: Curtis Ian Williams 
Published: April 2024

Abstract
Beckett criticism has long privileged vision and audition when discussing memory. The present study proposes to examine, rather, tactility in Beckett’s work. Touching and feeling are not only prominent features of what is remembered (or imagined, or remembered as never having occurred); they also trigger remembrance and body parts themselves hold memories. I argue that touching and holding are indispensable features of memories and of representations of remembering in Beckett’s postwar prose texts. The body remains a central preoccupation of his work up until the end of his life, and the body’s persistence in his work can help us revise our understanding of cognition generally, and memory specifically, in Beckett’s fictions.
Towards a Human Right to Psychological Continuity? Reflections on the Rights to Personal Identity, Self-Determination, and Personal Integrity
Authors: Ligthart Sjors 
Published: April 2024

Abstract
Scholars from different disciplines are increasingly debating how human rights should protect the autonomy not only over our bodies but also over our minds. These debates are often driven by emerging technologies that appear able to access, monitor, and manipulate mental states in ways that were previously inconceivable. Whereas some human rights already protect certain personal interests in the mental realm, such as the right to freedom of thought, it has been argued that new or updated human rights are necessary to offer adequate protection against modern technologies that may threaten our mental privacy, personal integrity, and identity. One of the proposed rights, which is under consideration by the Council of Europe and the UN Human Rights Council, concerns a right to ‘psychological continuity’. This paper challenges the necessity of recognising such a right, arguing that the notion of psychological continuity already receives considerable protection within the established framework of human rights law.