bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fatty Acid Synthase Inhibitory Activity of Acylphloroglucinols Isolated from Dryopteris crassirhizoma.
Authors: Na MinKyun , Jang JunPil , Min Byung Sun , Lee Sang Jun , Lee Myung Sun , Kim Bo Yeon , Oh Won Keun , Ahn Jong Seog 
Published: December 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Interfacing Electrocatalysis and Biocatalysis with Tungsten Carbide: A High‐Performance, Nobel‐Metal‐Free Microbial Fuel Cell.
Authors: Rosenbaum Miriam , Zhao Feng , Schroeder Uwe , Scholz Fritz 
Published: December 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Study of Nanostructured Materials by Optical and Photoelectron Spectroscopy
Authors: Adamchuk V. K. , Vinogradov A. S. , Vladimirov G. G. , Molodtsov S. L. , Prudnikova G. V. , Fedoseenko S. I. , Shikin A. M. 
Published: December 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
The Tishchenko Reaction: A Classic and Practical Tool for Ester Synthesis
Authors: Seki Tsunetake , Nakajo Tetsuo , Onaka Makoto 
Published: December 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Potential of Ionic Liquids in Greener Methodologies Involving Biocatalysis and Other Synthetically Important Transformations
Authors: Nara Susheel J. , Naik Prashant U. , Harjani Jitendra R. , Salunkhe Manikrao M. 
Published: December 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Asymmetric Synthesis with the Robust and Versatile 10‐Substituted 9‐Borabicyclo[3.3.2]decanes: Homoallylic Amines from Aldimines
Authors: Hernandez Eliud , Canales Eda , Gonzalez Eduvigis , Soderquist John A. 
Published: December 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Iridium‐Catalyzed Borylation of Arenes and Heteroarenes via C—H Activation
Authors: Ishiyama Tatsuo , Miyaura Norio 
Published: December 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Polyborane Reactions in Ionic Liquids
Authors: Li Yuqi , Kusari Upal , Carroll Patrick J. , Bradley Mark G. , Sneddon Larry G. 
Published: December 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
On the effectiveness of assessing model accuracy at design points for radial basis functions
Authors: Fang Hongbing , Wang Qian 
Published: December 2006

AbstractA study is performed on the effectiveness of assessing accuracies of radial basis functions (RBFs) at design (or sampling) points. The RBF has been shown to be appropriate for creating approximation functions for linear, quadratic, and higher‐order nonlinear responses even with a relatively small size of design samples. One favourable feature of RBFs is that all RBF models pass exactly through design points; therefore, an RBF model has no error at design points. However, this feature prevents the use of statistical parameters, which are commonly used in polynomial‐regression approximations, to obtain model accuracy based on evaluations at design points. Since obtaining additional samples for many complex engineering applications is expensive, it is desirable to have some knowledge of the model accuracy based on evaluations at design points so that the best RBF model(s) can be selected. In this study, the effectiveness of using statistical parameter R2 for prediction (R) is evaluated for two highly accurate RBFs using mathematical functions and real engineering applications. The results show that R is inappropriate for RBF models, and should be used cautiously for highly nonlinear responses with a small number of sampling points and/or a large number of design variables. Copyright © 2006 John Wiley & Sons, Ltd.
Comparative study of the least squares approximation of the modified Bessel function
Authors: Xin Jianguo 
Published: December 2006

AbstractThe least squares problem of the modified Bessel function of the second kind has been considered in this study with the Fourier series, Tchebycheff and Legendre approximation. Numerical evidence shows that the Gibbs phenomenon exists in the approximation with the truncated Fourier series, thus, giving poor convergence results compared with the other polynomial bases. For the latter two cases, the Legendre series perform better than Tchebycheff series in terms of the ℒ︁2 norm of the relative errors for each order of the polynomial approximation, and the ratio of the ℒ︁2 norm of the relative errors from the corresponding approximation seems to be a constant value of 1.3. Copyright © 2006 John Wiley & Sons, Ltd.
The use of environmental and social standards by German first‐tier suppliers of the Volkswagen AG
Authors: Beske Philip , Koplin Julia , Seuring Stefan 
Published: December 2006

AbstractSustainable supply chain management requires suppliers to be evaluated against a wider set of criteria. Quality standards (ISO 9000) play a central role for evaluating suppliers' economic performance, e.g. in the automotive industry. Regarding sustainability, the implementation of environmental and social standards could play a similar role. But almost no data is available on their degree of implementation or their importance for supplier evaluation.The aim of this survey (conducted in autumn 2003) was to evaluate whether and to what degree environmental and social standards have been implemented in the German car industry. The survey yielded 111 usable questionnaires, equalling a response rate of 29%. The results of the survey show that environmental standards, particularly ISO 14001, are already widely used, while this is not the case for social standards. The social dimension of sustainability has been lacking in implementation so far. Copyright © 2006 John Wiley & Sons, Ltd and ERP Environment.
Analytical comparison of frequency compensation techniques in three‐stage amplifiers
Authors: Grasso A. D. , Palumbo G. , Pennisi S. 
Published: December 2006

AbstractIn this paper, design equations of the most common Nested Miller topologies are derived. Moreover, a coherent and comprehensive analytical comparison among the different topologies is also presented. In particular, after deriving design equations, following the approach previously proposed by the authors that have the phase margin as the main design parameter, the different solutions are compared by evaluating a novel figure of merit that expresses a trade‐off between gain‐bandwidth product, load capacitance and total transconductance, for equal values of phase margin. It is shown that there is no unique optimal solution as this depends on the load condition and the relative magnitude of the transconductance of each stage. From this point of view, the proposed comparison also provides useful design guidelines for the optimization of small‐signal performance. Simulations confirming the effectiveness of the comparison are also given. Copyright © 2006 John Wiley & Sons, Ltd.
Triplet repeat in the Repin1 3′‐untranslated region on rat chromosome 4 correlates with facets of the metabolic syndrome
Authors: Klöting Nora , Wilke Barbara , Klöting Ingrid 
Published: December 2006

AbstractBackgroundCongenic and subcongenic rat strains confirmed the quantitative trait loci (QTLs) for facets of the metabolic syndrome between 60.53 and 77.11 Mb on chromosome 4. The analysis of candidate genes in this region favoured the replication initiator 1 (Repin1) characterized by a SNP in the coding region and a triplet repeat (TTT) in the 3′‐untranslated region (3′UTR).MethodsWe analysed nine rat strains (BB/OK, SHR, F344, BN, DA, LEW, hHTg, WOKW, and their founders WOK‐F) and four wild rats on DNA (sequencing) and RNA level (gene expression in blood, liver, subcutaneous, and epididymal adipocytes). In addition, the rats were phenotypically characterized in order to link the rat phenotype to genotype differences in the QTL on chromosome 4.ResultsWild rats were heterozygous for the SNP (C/T), whereas all the inbred strains were homozygous. The shortest triplet repeat was found in SHR (5) and the highest was found in hHTg and WOKW (11), which developed metabolic disorders. The repeat number correlated with most phenotypic traits studied. Using linear multiple regression analysis with repeat size as the dependent variable and considering all the data of this study, it was clearly demonstrated that not only VLDL cholesterol and serum insulin but also the expression of Repin1 in the liver is significantly associated with the repeat size of the 3′UTR.ConclusionsIt is concluded that the triplet repeat expansion in 3′UTR is involved in metabolic alterations as found in hHTg and WOKW rats and that the functional unknown gene, Repin1, could be a novel candidate gene for the development of facets of the metabolic syndrome. Copyright © 2006 John Wiley & Sons, Ltd.
Performance of a non‐load‐bearing steel stud gypsum board wall assembly: Experiments and modelling
Authors: Manzello Samuel L. , Gann Richard G. , Kukuck Scott R. , Prasad Kuldeep , Jones Walter W. 
Published: December 2006

AbstractA gypsum wall assembly was exposed to an intense real‐scale compartment fire. For the wall assembly, temperatures were measured at the exposed face, within the stud cavity, and at the unexposed face during the fire exposure. Total heat flux gauges were used to measure the temporal variation of the energy incident on the walls, and cameras, both visual and infrared, were used to image the unexposed face of the wall assembly during the fire exposure. The behaviour of the wall assembly under the fire load is discussed as are current model results for a simulation of the fire test. Copyright © 2006 John Wiley & Sons, Ltd.
Predicting HCl concentrations in fire enclosures using an HCl decay model coupled to a CFD‐based fire field model
Authors: Wang Z. , Jia F. , Galea E. R. , Patel M. K. , Ewer J. 
Published: December 2006

AbstractThe amount of atmospheric hydrogen chloride (HCl) within fire enclosures produced from the combustion of chloride‐based materials tends to decay as the fire effluent is transported through the enclosure due to mixing with fresh air and absorption by solids. This paper describes an HCl decay model, typically used in zone models, which has been modified and applied to a computational fluid dynamics (CFD)‐based fire field model. While the modified model still makes use of some empirical formulations to represent the deposition mechanisms, these have been reduced from the original three to two through the use of the CFD framework. Furthermore, the effect of HCl flow to the wall surfaces on the time to reach equilibrium between HCl in the boundary layer and on wall surfaces is addressed by the modified model. Simulation results using the modified HCl decay model are compared with data from three experiments. The model is found to be able to reproduce the experimental trends and the predicted HCl levels are in good agreement with measured values. Copyright © 2006 John Wiley & Sons, Ltd.
Genome‐wide linkage scan for breast cancer susceptibility loci in Swedish hereditary non‐BRCA1/2 families: Suggestive linkage to 10q23.32‐q25.3
Authors: Bergman Annika , Karlsson Per , Berggren Jonna , Martinsson Tommy , Björck Karin , Nilsson Staffan , Wahlström Jan , Wallgren Arne , Nordling Margareta 
Published: December 2006

AbstractThe two breast cancer genes BRCA1 and BRCA2 were identified more than 10 years ago and, depending on population, mutations in these genes are responsible for a varying percentage of familial breast cancer. In more than half the families, the increased risk of breast cancer cannot be explained by mutations in these genes, and the goal of this study was to locate novel susceptibility genes. One of the main difficulties in identifying the cause of hereditary non‐BRCA1/BRCA2 breast cancer is genetic heterogeneity, possibly due to multiple, incompletely penetrant susceptibility genes, along with ethnic and geographic differences. In this study, one large family and 13 small to medium‐sized families with multiple cases of breast cancer were analyzed by genome‐wide linkage analysis. The genome scan was performed by genotype analysis of 10,000 SNP markers on microarrays. The strongest evidence of linkage (HLOD 2.34) was obtained on chromosome region 10q23.32‐q25.3. A further two regions were identified, with LOD scores above 2.10 on 12q14‐q21 and 19p13.3‐q12. In a subset of families of western Swedish origin, two regions generated LOD scores exceeding 1.8: 10q23.32‐q25.3 and 19q13.12‐q13.32. The large family in the study exceeded LOD 1.5 in three regions: 10q23.32‐q25.3, 19q13.12‐q13.32, and 17p13. Our results indicate that one or more of the suggested regions may harbor genes that are involved in the development of breast cancer. © 2006 Wiley‐Liss, Inc.
Common polymorphisms in TP53 and MDM2 and the relationship to TP53 mutations and clinical outcomes in women with ovarian and peritoneal carcinomas
Authors: Galic Vijaya , Willner Julia , Wollan Melissa , Garg Ruchi , Garcia Rochelle , Goff Barbara A. , Gray Heidi J. , Swisher Elizabeth M. 
Published: December 2006

AbstractThe importance of somatic TP53 mutations and germline TP53 codon 72 genotype in the survival of women with epithelial ovarian cancer is controversial. Recent data suggest that a promoter polymorphism in the MDM2 gene may influence age of cancer onset in a gender‐specific fashion. We sought to determine the relationship between somatic TP53 mutations, germline genotypes at TP53 codon 72 and MDM2 SNP309, and overall survival and response to chemotherapy in a large series of patients with ovarian and peritoneal carcinomas. Of the 188 cancers, 103 (54.8%) had a TP53 mutation, of which 71% were missense mutations and 29% were null mutations. TP53 mutation status and mutation type (null vs. missense) did not influence response to therapy or overall survival. Women with the codon 72 Pro/Pro had a decreased overall survival (median, 29 months) compared with women with one or two arginine alleles (median, 49 months; P = 0.04). Somatic mutation or deletion was equally common for either codon 72 allele. Age of diagnosis was not influenced by codon 72 but showed a trend for younger age in women with somatic TP53 mutations and the MDM2 G/G genotype. © 2006 Wiley‐Liss, Inc.
Targets of genome copy number reduction in primary breast cancers identified by integrative genomics
Authors: Chen Wei , Salto‐Tellez Manuel , Palanisamy Nallasivam , Ganesan Kumaresan , Hou Qingsong , Tan Lay Keng , Sii Lang Hiong , Ito Kosei , Tan Benita , Wu Jeanie , Tay Andrew , Tan Kok Chai , Ang Erik , Tan Bien Keem , Tan Puay Hoon , Ito Yoshiaki , Tan Patrick 
Published: December 2006

AbstractThe identification of specific oncogenes and tumor suppressor genes in regions of recurrent aneuploidy is a major challenge of molecular cancer research. Using both oligonucleotide single‐nucleotide polymorphism and mRNA expression arrays, we integrated genomic and transcriptional information to identify and prioritize candidate cancer genes in regions of increased and decreased chromosomal copy number in a cohort of primary breast cancers. Confirming the validity of this approach, several regions of previously‐known copy number (CN) alterations in breast cancer could be successfully reidentified. Focusing on regions of decreased CN, we defined a prioritized list of eighteen candidate genes, which included ARPIN, FBN1, and LZTS1, previously shown to be associated with cancers in breast or other tissue types, and novel genes such as P29, MORF4L1, and TBC1D5. One such gene, the RUNX3 transcription factor, was selected for further study. We show that RUNX3 is present at reduced CNs in proportion to the rest of the tumor genome and that RUNX3 CN reductions can also be observed in a breast cancer series from a different center. Using tissue microarrays, we demonstrate in an independent cohort of over 120 breast tissues that RUNX3 protein is expressed in normal breast epithelium but not fat and stromal tissue, and widely down‐regulated in the majority of breast cancers (>85%). In vitro, RUNX3 overexpression suppressed the invasive potential of MDA‐MB‐231 breast cancer cells in a matrigel assay. Our results demonstrate the utility of integrative genomic approaches to identify novel potential cancer‐related genes in primary tumors. This article contains Supplementary Material available at http://www.interscience.wiley.com/jpages/1045‐2257/suppmat. © 2006 Wiley‐Liss, Inc.
Methyl tert‐butyl ether (MTBE)‐induced cytotoxicity and oxidative stress in isolated rat spermatogenic cells
Authors: Li Dongmei , Yin Daqiang , Han Xiaodong 
Published: December 2006

AbstractMethyl tert‐butyl ether (MTBE) is a class of synthetic organic chemical. In the USA, MTBE pollution is regarded as a serious environmental problem. The objective of the present study was to investigate the cytotoxic effects and oxidative stress induced by MTBE in isolated rat spermatogenic cells. In cytotoxic experiments, spermatogenic cells isolated from the testes of adult Sprague‐Dawley rats by a mechanical procedure without the use of trypsin were incubated with medium alone (control), 0.5, 5, 50 mm MTBE, respectively, for 6, 12 and 18 h. MTT assay, staining with fluorescein diacetate (FDA) and propidium iodide (PI) and flow cytometric analyses were used. In oxidative stress experiments, the spermatogenic cells were incubated with medium alone (control) and with 0.5, 50 μm, 5 mm MTBE. For 1, 2, 6, 12, 18 h incubation, ROS production was tested using a 2′,7′‐dichlorofluorescein diacetate (DCHF‐DA) probe; for 1, 3, 6, 12, 18 h incubation, cytosolic superoxide dismutase (SOD) and extracellular SOD (SODEX) activity was assessed; and for 18 h incubation, lipid peroxidation was assessed. The results showed that MTBE at high doses significantly decreased the spermatogenic cell viability and increased plasma membrane damage and the ratio of necrotic cells compared with the control. Assessment of the MTBE‐induced oxidative stress revealed that MTBE increased the production of reactive oxygen species (ROS) and enhanced lipid peroxidation. In addition, although SODEX activity increased at a high dose level, cytosolic SOD activity decreased. These results suggest that an increase of MTBE‐induced ROS production and an enhancement of membrane lipid peroxidation may play an important role in its cytotoxicity in isolated rat spermatogenic cells. Copyright © 2006 John Wiley & Sons, Ltd.
Interaction of rat renal glucocorticoid receptor with Hsp90 and Hsp70 upon stress provoked by mercury
Authors: Brkljačić Jelena , Perišić Tatjana , Dundjerski Jadranka , Matić Gordana 
Published: December 2006

AbstractThe influence of mercury on the association of rat kidney glucocorticoid receptor (GR) with heat shock proteins Hsp90 and Hsp70 was investigated. The GR heterocomplexes with Hsp90 and Hsp70 were immunopurified from the renal cytosol of rats administered different doses of mercury (1, 2 and 3 mg Hg kg−1b.w.). A quantitative immunoblotting procedure was applied to determine the levels of GR, Hsp90 and two nucleocytoplasmic Hsp70 isoforms (constitutive Hsp73 and inducible Hsp72) in the renal cytosol, as well as the amounts of these proteins within GR heterocomplexes immunoprecipitated by anti‐GR antibody. Mercury was found to stimulate GR association with all the examined Hsps. The most prominent effect of the metal was stimulation of Hsp72 interaction with GR. On the other hand, the metal administration led to an increase of Hsp90 level in the cytosol, while the cytosolic levels of Hsp70 isoforms remained unaltered. These findings suggest that association of Hsps, at least Hsp70, with the GR might be ascribed to changes in the affinity of their interaction rather than to changes in the Hsp availability in the cytosol. Therefore, GR heterocomplex assembly seems to be a controlled process enabling chaperoning and functioning of the GR to be in concert with physiological demands. Copyright © 2006 John Wiley & Sons, Ltd.
Osteoprotegerin expression in dendritic cells increases with maturation and is NF‐κB‐dependent
Authors: Schoppet Michael , Henser Stephanie , Ruppert Volker , Stübig Thomas , Al‐Fakhri Nadia , Maisch Bernhard , Hofbauer Lorenz C. 
Published: December 2006

AbstractDendritic cells (DC) comprise a unique leukocyte population which controls primary immune responses. Recent studies indicate that DC express osteoprotegerin (OPG), a secreted tumor necrosis factor receptor homolog, which regulates DC survival, monocyte chemotaxis, and B cell development and function by ligating TNF family member receptor activator of NF‐κB ligand (RANKL). The precise regulators of OPG expression in DC have not been investigated. In this study, we assessed OPG mRNA steady state levels by Northern blot analysis and OPG protein secretion by an immunoassay in monocyte‐derived DC of different maturation, and the effect of different cytokines and hormones on OPG expression. OPG was upregulated with maturation of DC, whereas pretreatment of DC with 1α,25(OH)2 vitamin D3, tamoxifen, or dexamethasone, agents that inhibit differentiation of DC, decreased OPG expression. In vivo, OPG was found to be colocalized with mature CD83+ DC in human tonsils by immunofluorescence confocal microscopy analysis. Furthermore, OPG was upregulated by TNF superfamily members TNF‐α, anti‐CD40, and RANKL, and by ligands of the Toll‐like/IL‐1 receptor family including IL‐1β, double‐stranded RNA (poly I:C), or lipopolysaccharide (LPS), all of which induce maturation of DC. Gene silencing by small interfering RNA (siRNA) directed against transcription factor NF‐κB abrogated the expression of OPG as demonstrated by real‐time PCR. In summary, we describe that the expression of OPG by DC increases with maturation and is NF‐κB‐dependent, possibly regulating immune responses in lymphoid tissues. J. Cell. Biochem. 100: 1430–1439, 2007. © 2006 Wiley‐Liss, Inc.