bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intestinal polyposis and periampullary carcinoma—changing concepts
Authors: Guyton Daniel P. , Schreiber Helmut 
Published: February 2007

AbstractAdenomatous polyps lead directly to carcinoma of the colon in patients with one of the familial syndromes of intestinal polyposis. Elective colectomy is prophylactic and life‐saving. A subgroup of patients will develop periampullary carcinoma, again arising from the presence of adenomatous polyps. Such a case is presented. These polyps should be surgically excised to ensure adequate pathologic examination. Yearly upper endos‐copic examination is an essential element of management. Either the presence of carcinoma in situ or the recurrence of these polyps following excision is confirmation of behavior with a high propensity for the devleopment of invasive cancer and requires aggressive treatment.
Plasma proteins as indices of response to nutritional therapy in cancer patients
Authors: Ota David M. , Frasier Pamela , Guevara Juan , Foulkes Mary 
Published: February 2007

AbstractThe use of plasma albumin (ALB), transferrin (TFN), prealbumin (TBPA), retinol‐binding protein (RBP), triceps skin fold (TSF), and midarm muscle circumference (MAMC) as determinants of response to nutritional therapy (TPN) was investigated in 40 cancer patients during preoperative TPN. Thirty‐one patients received 90% or more of their anabolic caloric requirement (Harris‐Benedict equation) by means of TPN. During this study period (average 11.1 ± 4.7 days) nutritional assessments were completed before TPN and on the last day of TPN before surgery. Average weight loss based on usual body wt (UBW) and ideal body wt (IBW) was 19 ± 11% and 9 ± 15%, respectively (not significant, NS). Weight loss (UBW) correlated with ALB (P < 0.001), TBPA (P < 0.005) and RBP (P < 0.02) but did not correlate with TFN (P < 0.06), TSF, and MAMC. Weight loss (IBW) correlated with TSF (P < 0.01) and MAMC (P < 0.03) but did not correlate with plasma protein (PP). During TPN the average percent increases for PP were 0.1% (ALB, NS), 20% (TFN, NS), 60% (TBPA, P < 0.02), and 116% (RBP, P < 0.005). These results suggest that plasma TBPA and RBP are significant parameters of response to short‐term nutritional therapy in cancer patients.
Untreated colorectal cancer in a community hospital
Authors: Johnson Houston 
Published: February 2007

AbstractThe tumor registry of a community hospital has been reviewed, and 60 patients with untreated colon and rectal cancer have been identified. Thirty‐four patients were black and 26 patients were white. Sixty‐five percent of black patients had specified colonic lesions primarily distributed in the right colon and proximal to the splenic flexure. Sixty‐three percent of white patients had specified lesions localized to the sigmoid colon. The patients had disease in local, regional, and disseminated stages, and lethality was associated with all stages. Forty‐eight percent of patients expired in less than 30 days after presenting to the hospital, and two‐thirds expired between 1 and 2 months of presentation. Only two patients survived more than 1 year. These data suggest that untreated colorectal cancer will be nearly uniformly fatal early in all patients who go untreated.
Lymphocyte populations with abnormal kappa:lambda ratios in reactive lymphoid hyperplasia
Authors: Bain Vincent G. , Bain Gordon O. 
Published: February 2007

AbstractThe lymph node biopsies of 12 patients with lymphadenopathy due to reactive hyperplasia contained lymphocyte populations with increased percentages of B‐cells and abnormal numbers of cells with single class surface immunoglobulins. Ten patients were followed for periods of 3–30 months: one developed a non‐Hodgkin's lymphoma and one Hodgkin's disease. One other has persisting lymph node enlargement. Two patients had nonlymphoid malignancies. The other six remain well without lymphadenopathy. Twenty‐five of 40 patients with reactive lymph node hyperplasia and normal kappa/lambda ratios followed for 9–36 months had a similar incidence of lymphoid malignancy and persistent lymph node enlargement. The follow‐up data so far available do not support a hypothesis that reactive lymphoid hyperplasia with increased numbers of cells with single class surface immunoglobulin is associated with higher morbidity than reactive hyperplasia containing the usual polytypic lymphocyte populations.
Breast carcinoma metastatic to eyelids: Case report and review of the literature
Authors: Dabski Krzysztof , Milgrom Halina , Stoll Howard L. 
Published: February 2007

AbstractViolaceous, indurated plaques around both eyes were found to be cutaneous metastases and the initial clinical presentation of a lobular carcinoma of the breast in an 80‐year‐old woman. Available literature indicates that breast carcinoma is the most common metastatic tumor of the eyelid and the onset of a palpebral mass may precede the diagnosis of the primary tumor in the breast.
Pathological evaluation of hepatic dearterialization in encapsulated hepatocellular carcinoma
Authors: Tanaka Nobutaka , Okamoto Eizo , Toyosaka Akihiro , Fujiwara Shiro 
Published: February 2007

AbstractSpecimens of encapsulated hepatocellular carcinoma from 48 patients who had received no previous treatment and from six patients previously treated by hepatic arterial interruption by embolization or ligation were obtained by resection and examined for incidence and extent of necrosis of the tumor. Among the 48 specimens from the non‐pre‐treated patients, 25 tumors were smaller than 5 cm and showed no notable necrosis; of the 23 remaining tumors—which were larger than 5 cm—12 (52%) showed spontaneous central necrosis. The necrosis rate of the tumor ranged from 10% to 40%. In contrast, in six specimens from pretreated cases, more than 60% of the tumors were found to be necrotic. Two tumors smaller than 5 cm were completely necrotized by embolization. The findings indicated the significance of hepatic dearterialization for the management of encapsulated hepatocellular carcinoma. Daughter nodules, however, were found to have escaped necrosis.
Detection of ABO(H) blood group antigens: A study in tissue culture
Authors: Feinmesser R. , Gay I. , Brama I. 
Published: February 2007

AbstractThe association between malignant tranformation and the loss of ABO(H) blood group antigens was documented by several authors. Most of the work was done on paraffin sections, though a small portion was performed on fresh frozen tissues. We suggest that the specific red cell adherance (SRCA) test can be applied to tissues cultivated in tissue culture for determination of malignant transformation. This study supports this assumption.
Management of cardiac tamponade in patients with malignancy
Authors: Reitknecht Felice , Regal Anne‐Marie , Antkowiak Joseph G. , Takita Hiroshi 
Published: February 2007

AbstractFrom January 1967 through November 1983, 66 patients with a previously established diagnosis of malignancy were treated for pericardial effusion by the creation of a pericardial window. The majority of the patients had malignancies of the breast or lung, or lymphoma. There were no deaths or major complications attributable to the operative procedures.The presence of malignant pericardial effusion is usually evidence of far‐advanced disease and, therefore, the prognosis is poor. Seventeen patients (26%) were alive 1 or more years postoperatively and 33 patients (50%) died within 3 months of operation. Despite the grave prognosis, it is still our belief that malignant pericardial effusion should be treated aggressively by open surgical drainage so that continuation of therapy for the primary malignancy would be possible.
In vitro antibiotic activity of 11 beta‐lactam antibiotics in a cancer center
Authors: Landoy Zvi , Rotstein Coleman , Surgalla Michael J. , Botzer Robert , Fitzpatrick John E. , Blumenson Leslie E. 
Published: February 2007

AbstractTwo‐thousand, five‐hundred and twenty‐four bacterial isolates were tested against 11 new beta‐lactam antibiotics in a prospective study conducted in a cancer center. E. coli, P. aeruginosa, and K. pneumoniae were the most common gram‐negative organisms isolated, while S. aureus and Entero‐cocccus were the most common organisms among the gram‐positive. The new cephalosporins were more active than the semisynthetic penicillins against E. coli, P. aeruginosa, and K. pneumoniae (p<0.001). Mezlocillin had better activity than the other semisynthetic penicillins against most of the gram‐negative organisms as well as the enterococci. As a result, mezlocillin was preferred as a beta‐lactam agent to be employed with an aminoglycoside as empiric antibiotics for febrile patients with neoplasia.
Clinical uses of prosthetic devices in brachiotherapy for oral cavity tumors
Authors: Sela M. , Weshler Z. , Loewental E. , Taicher S. 
Published: February 2007

AbstractThree different acrylic resin intraoral stents used for radiotherapy are described. They serve multiple functions in the treatment of tumors of the oral cavity. They are prepared individually and are necessary for accurate treatment planning and in order to minimize the exposure of hospital personnel to radiation.
The simultaneous coexistence of adenocarcinoma and primary malignant lymphoma in the stomach
Authors: Czerniak Abraham , Lotan Gad , Engelberg Isaac S. , Rabau Micha Y. , Avigad Itamar , Schachter Pinhas , Wolfstein Isidor 
Published: February 2007

AbstractA case of simultaneous adenocarcinoma and primary malignant lymphoma as two independent growths of the stomach is presented. Review of the literature documented two such cases along with nine cases of the collision‐tumor type. The differential criteria between this entity and collision tumor and carcinosarcoma are emphasized. Diagnosis and treatment is discussed.
Long‐term ambulatory treatment of metastatic colorectal adenocarcinoma by continuous intravenous infusion of 5‐fluorouracil
Authors: Quebbeman E. , Ausman R. , Hansen R. , Becker T. , Caballero G. , Ritch P. , Jenkins D. , Blake D. , Tangen L. , Schulte W. 
Published: February 2007

AbstractTo delineate the efficacy of continuous intravenous 5‐fluorouracil (5‐FU) infusion therapy for advanced colorectal adenocarcinoma, a study of 36 patients with measurable metastatic disease was conducted. Patients received a daily intravenous infusion of 300 mg/m2 5‐FU over a 24‐h period utilizing portable infusion devices and central venous catheters. In a population characterized by substantial pretreatment exposure to radiotherapy, chemotherapy, and other indicators of poor prognosis, 13/36 (36%) patients achieved an objective response. An additional 10/36 (28%) patients manifested stable disease (no change) and experienced survival comparable to. that of patients with objective response. Toxicity was minimal; patients were able to continue 5‐FU infusions 95% of the total time on protocol. There were no adverse hematologic effects or catheter complications. Because previously untreated patients benefited more frequently (positive response, 50%), continuous intravenous infusion should be evaluated further as a primary modality option when 5‐fluorouracil antitumor chemotherapy is contemplated.
Hemicorporectomy
Authors: Aust J. Bradley , Page Carey P. 
Published: February 2007

AbstractTranslumbar amputation (hemicorporectomy) was first successfully performed in 1961 after cadaver feasibility dissections. It is useful for certain slow‐growing malignancies of the pelvis and perineum and for patients with advanced sepsis involving pelvic bony structures. As indicated by our 20‐year experience, the operation may be rewarded by control of a malignant process (two patients) and/or relief from chronic pelvic sepsis (four patients), survival and discharge from the hospital after lengthy rehabilitation (six patients).
Spontaneous retroperitoneal hemorrhage secondary to a renal cause
Authors: Drago Joseph R. , York Jeffrey P. , Dagen J. Edward , Rohner Thomas J. 
Published: February 2007

AbstractSpontaneous rupture of normal renal parenchyma must indeed be rare. Virtually all patients in this paper had a significant abnormality that presented with bleeding.Our Case 5 is the only one without a clear underlying pathologic entity. We should stress the high incidence of associated disease in kidneys that bleed “spontaneously” and therefore the need for exploration and/or nephrectomy.
Seminoma arising in undescended testis clinically presenting as acute appendicitis
Authors: Sarma Deba P. , Weilbaecher Thomas G. , Hatem Ali A. 
Published: February 2007

AbstractA 48‐year‐old man with a clinical diagnosis of acute appendicitis on exploration was found to have a seminoma in an undescended pelvic testis. The tumor had directly invaded the retrocecal appendix, causing acute appendicitis. Such a highly unusual occurrence has not been described in the English literature.
Malignant fibrous histiocytoma of the larynx
Authors: Godoy Jose , Jacobs John R. , Crissman John 
Published: February 2007

AbstractMalignant fibrous histiocytomas of the upper respiratory tract are rare, aggressive, mesenchymal neoplasms. There have been sporadic cases reported in the English language literature. This paper reports the case of a subglottic malignant fibrous histiocytoma in a 26‐year‐old female. A review of the important clinical‐pathological features of this type of tumor is presented. The treatment of choice appears to be wide surgical resection of the tumor. Although the published experience is small, it appears that tumors of the subglottic space are characterized by a younger patient population and a better prognosis than those of the larynx.
Spindle cell mucoepidermoid carcinoma of submandibular gland
Authors: Love Gordon L. , Sarma Deba P. 
Published: February 2007

AbstractA malignant tumor of the submandibular gland was found to consist predominately of spindle cell elements that initially suggested a primary sarcoma. Further examination revealed that the spindled malignant cells were derived from a high‐grade mucoepidermoid carcinoma.
Massive hemoperitoneum secondary to spontaneous rupture of hepatic metastases: Report of two cases and review of the literature
Authors: Urdaneta Luis F. , Nielsen Jeffrey V. 
Published: February 2007

AbstractTwo cases of massive hemoperitoneum secondary to spontaneous rupture of hepatic metastases are presented. This devastating complication of hepatic malignant disease is difficult to diagnose preoperatively. However, the diagnosis should be considered in patients with known malignant disease who present with unexplained blood loss, shock, or signs consistent with an acute surgical abdomen. The presence of fever and leukocy‐tosis with these signs and symptoms may also be part of the clinical picture. Treatment by hepatic resection is never curative. Review of the literature indicates that local control of the bleeding site by suture ligature, packing with topical hemostatic agents, or hepatic artery ligation offers the best chances of obtaining hemorrhage control and some degree of palliation in these desperately ill patients.
Cervical lymph node metastases of oral carcinoma related to the depth of invasion of the primary lesion
Authors: Thompson Stevan H. 
Published: February 2007

AbstractSquamous cell carcinoma of the tongue has been found to have a greater frequency of cervical metastases on initial examination than lesions affecting other oral sites. This study analyzes a sample of 21 pathological specimens of oral carcinoma and block neck dissections relating the confirmed historical presence of cervical metastasis to the depth of invasion of the primary lesion. Tongue carcinomas were compared with lesions affecting other oral sites. An arbitrary anatomical levelling system was devised to assess the depth of invasion. Tongue carcinomas show a propensity to infiltrate more deeply than lesions affecting other oral sites. For the entire sample, carcinomas infiltrating the superficial lamina pro‐pria occurred much less frequently than lesions showing a deeper infiltration pattern. Overall, lesions infiltrating the deep lamina propria do not exhibit a reduced frequency of occurrence compared to lesions infiltrating me skeletal muscle; however, carcinomas affecting other oral sites showed a reduced frequency of deeply infiltrating lesions in comparison to more superficial lesions. Carcinomas confined to the superficial lamina propria seem to have a better prognosis in relation to developing cervical metastases, and this does not appear to be influenced by age, sex, site, size or degree of differentiation.
Malignancy and differentiation of neoplastic epithelial cells of thymoma
Authors: Monden Yasumasa , Tanioka Tsuneo , Maeda Masazumi , Masaoka Akira , Nakahara Kazuya , Kawashima Yasunaru , Kitamura And Hajime 
Published: February 2007

AbstractFifteen fetal thymuses and 100 thymomas were examined concerning the degree of differentiation of thymic epithelial cells by light and electron microscopy. The following results were obtained. 1) The embryologic process of the fetal thymus was categorized into four stages (8, 12, 15, and 17 weeks or more of gestation) based on the morphological features of epithelial cells and the maturity of thymic tissues. (2) Thymomas were classified into the undifferentiated, and poorly, moderately, and well‐differentiated types by their morphological features in comparison with the fetal thymuses. The incidences of the respective types in the 100 thymomas were 5, 16, 68, and 11 cases. (3) The moderately differentiated type was divided into three subtypes; namely, polygonal cell (49 cases), clear cell (6), and spindle cell type (13). (4) The degree of differentiation of the thymomatous epithelial cells showed strong correlations with both the invasiveness and the prognosis of the thymoma. The ratios of invasive thymomas were 36, 47, 25, and 100% for the well‐differentiated, moderately‐differentiated, poorly‐differentiated, and undifferentiated types, respectively. The 10‐year survival rates were 87.5, 62.5, 46.9 and 0% for the well‐differentiated, moderately‐differentiated, poorly‐differentiated, and undifferentiated thymomas.
Technical aspects of resection of pelvic tumors
Authors: Karakousis Constantine P. 
Published: February 2007

AbstractTumors in the greater or lesser pelvis with lateral fixation present difficulties in their resection due to inadequate exposure distally. Two illustrative examples of such tumors, of a total of 26 pelvic tumors, suggest that resection of tumors in the pelvis with lateral fixation is facilitated with the use of the abdominoinguinal incision, ligation of one or both internal iliac arteries, and dissection at clean planes away from the tumor surface.
Monitoring the histogenesis of colonic tumors in the Sprague‐Dawley rat
Authors: Rubio C. A. , Nylander G. , Wahlin B. , Sveander M. , Duvander A. , Alun M.‐L. 
Published: February 2007

AbstractA total of 306 male Sprague‐Dawley rats, injected with dimethylhydrazine (DMH), dose 21 mg/kg body weight s.c, were investigated. Of the 109 rats receiving the dose once only, seven colonic adenocarcinomas developed; all seven (100%) were seen to originate in discrete lymphoid patches. Of the 97 rats treated with one dose/week for 3 months, only 6% of the 50 adenocarcinomas developed in discrete lymphoid patches, while 46% were seen to originate in a pre‐existing adenoma. Of the remaining 100 rats, receiving one dose/week for 6 months, only 3.5% of the 57 adenocarcinomas arose from discrete lymphoid patches; 43.9% arose from a pre‐existing adenoma. Thus, the histogenesis of adenocarcinomas at our laboratory appears to be dose‐dependent. Experiments are therefore being designed to monitor in detail the events of these two histogenetically different adenocarcinomas in the colonic mucosa in our animal model.
Survival and locations of recurrence following abdomino‐perineal resection for rectal cancer
Authors: Danzi M. , Ferulano G. P. , Abate S. , Dilillo S. , Califano G. 
Published: February 2007

AbstractRecords of 134 patients treated by abdomino‐perineal resection (1971–1979) were reviewed. One hundred and thirteen had curative operations. Mortality was 2.6% and morbidity was 51 %. Ninety‐three were evaluable and were followed for 5 to 8 years; they were evaluated for survival and pattern of recurrence. Five‐year survival for Dukes' A,B,C, and D lesions was 86,62,31, and 0%, respectively. Thirty‐seven had recurrence: Four pelvic, nine pelvic and distant, and 24 only distant lesions. The overall incidence of failures was 47 %, failure rates by stage were 11 % for stage A, 27% for B, 48% for C, and 70% for D. Incidence of local recurrence was significantly higher in stage C compared to stage B. Irrespective of stage, after detection of local or distant recurrence, survival did not differ. Furthermore, radiotherapy for local recurrence and chemotherapy for distant lesions did not improve survival time.
Endobronchial metastasis of renal cell carcinoma
Authors: Noy Shlomo , Michowitz Moshe , Lazebnik Noam , Baratz Mimi 
Published: February 2007

AbstractEndobronchial metastasis from nonpulmonary carcinoma is rare. A case of metastatic renal cell carcinoma is presented and the literature reviewed. Severe haemoptysis was the initial symptom leading to the finding of a bronchial polypoid mass.
A misleading flow cytometric analysis of dna in an adenocarcinoma: A comparative flow cytometric and cytogenetic study
Authors: Lee Greta M. , Youngberg George A. 
Published: February 2007

AbstractA case is presented in which flow cytometric and cytogenetic analysis was done on a biopsy from a highly anaplastic metastatic adenocarcinoma. Flow cytometric analysis of DNA content failed to show a significant population of aneuploid cells. However, histologic examination revealed a substantial number of tumor cells, and cytogenetic analysis produced chromosome counts ranging from 20 to 144.
Effect of fractionated irradiation prior to conservative and radical surgery on therapeutic gain in a spontaneous fibrosarcoma of the C3H mouse
Authors: Todoroki Takeshi , Suit Herman D. 
Published: February 2007

AbstractThe efficacy of fractionated irradiation given preoperatively was examined using early generation isotransplants of a spontaneous fibrosarcoma (FSaII) growing in the right leg of syngeneic C3Hf/Sed mice and employing as endpoints local tumor control probability, normal tissue damage (5 mm leg shortening), and distant metastasis. Complete dose response assays have been performed on small (4–5 mm) and large (8 mm) tumors. TCD50s (the dose that on average would be expected to control half the irradiated tumors) for radiation given in five equal doses (1 day between treatments) were 93.6 and 111.8 Gy for the 4–5 and 8‐mm tumors, respectively. Surgery was performed under a dissecting (8×) microscope at 5–6 days after the completion of irradiation. For small tumors, radical (en bloc) and conservative (local) resection alone achieved 69.8 (30/43) and 21.9% (7/32) tumor control, respectively. The corresponding figures for large tumors were 25 (8/32) and 6.1 % (2/33), respectively. Preoperative irradiation increased tumor control rate up to 100% at dose levels much lower than TCD50 for radiation alone. Enhancement ratios (ER) were computed for preoperative radiation as follows: TCD50 for radiation alone/TCD50 for radiation and surgery. ERs were computed for local and en bloc resection for tumor control and for leg shortening. From these ER values, therapeutic gain factors (TGF) were then computed for local and en bloc resection for tumor control and for leg shortening. From these ER values, therapeutic gain factors (TGF) were then computed as ER tumor response/ER leg shortening. In small tumors, the TGFs (TCD80 and legshortening of 5 mm) were 2.1 and 2.0 for conservative and radical resection, respectively. Corresponding figures for large tumors were 1.5 and 1.5. In this experimental system for small and large tumors, radiation treatment prior to conservative surgery achieved a comparable therapeutic gain to that by combining radiation with radical surgery. No effect of preoperative fractionation on the frequency of distant metastasis was observed.