bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effectiveness of the combination of clapping and common cold massage therapy on breathing frequency and number of staphylococcus bacteria in toddlers with upper respiratory tract infections (ARI)
Authors: Firdaus  , Santoso Andreas Putro Ragil , Munjidah Annif , Masita Elly Dwi , Mardiyant Ika , Heris Santy Wesiana 
Published: March 2024

Introduction: The common cold is an emergency that often occurs in children due to shortness of breath and even death, so attempts are needed to massage the baby so that respiratory failure does not happen. Not only massage but a combination with percussion (clapping) as a physical chest therapy (CPT) helps effectively against breathing difficulties and respiratory infections in toddlers. Thus, this research is aimed to evaluate the effectiveness of clapping and common cold massage combination therapy on breathing frequency and the number of staphylococcus bacteria in toddlers with upper respiratory tract infections (ARI)
Methods: This quantitative research used a quasi-easy experiment with a pre-test and a post-test with a control group. The population in this study was PKM Sidoarjo, Indonesia. The sample size was 42 people. Sampling was done by consecutive selection. This study was divided into the intervention group, which received massage and clapping therapy, and the control group only received massage therapy. Data analysis was performed using the Wilcoxon Sign Rank statistical test in the SPSS 25.
Results: According to the age category, most respondents in both groups were one (K1: 45.5%; K2: 54.0%). We reported a respiratory rate decrease in the sample after the massage therapy. The reduction in the respiratory rate was 2.50 times, and decrease in Staphylococcus bacteria in the sample after getting the massage therapy. The amount of decrease in Staphylococcus bacteria rate was 3.50 times. A significant difference in the increase in the respiratory rate was established in the group that had a massage and clapping therapy (p=0.000), and the amount of Staphylococcus bacteria was found in the group that had a massage and clapping treatment (p=0.000). The amount of decrease in Staphylococcus bacteria was 10.50 times.
Conclusion: The combination of clapping therapy and cold massage therapy will affect the respiratory frequency and the number of Staphylococcus bacteria. So, it is necessary to motivate parents, especially mothers, to do one of the usual cold massage therapy movements.
Nutrient analysis of fermented chicken feather fertilizer waste using Bacillus subtilis on the growth of green spinach (Amaranthus tricolor)
Authors: Tobing Lukiyono Yauwan , Wikurendra Edza Aria , Salsabilah Zain Salfa , Utomo Satriyo Siswo 
Published: March 2024

Introduction: Farmers generally provide NPK chemical fertilizers (Nitrogen, Phosphorus, Potassium) to provide nutrients for green spinach plants. However, the use of NPK chemical fertilizers harms the environment. Nowadays, chicken feathers are known as beneficial for fertilizing plants, similar to NPK chemical fertilizers. Fermentation of chicken feathers by Bacillus sp. can improve the quality of protein in chicken feather fertilizers which can be used as a supplement in renewing soil conditions. Thus, this study is aimed to evaluate the nutrient component of fermented chicken feather fertilizer waste using Bacillus subtilis on the growth of green spinach (Amaranthus tricolor)
Methods: This was a cross-sectional study. In this study, we used a total sampling technique. In this study, three groups got different chicken father fertilizers, and two groups of standard and did not get the chicken father fertilizer. Data from the research will be statistically analyzed descriptively. The descriptive data will provide in the table.
Results: In the first treatment group, the value of nitrogen (N) was 2.439, phosphorus (P) was 2.225%, and potassium (K) was 2.408%. In the second treatment group, the nitrogen (N) value obtained 2.866%, the phosphorus (P) value was 2.174%, and the potassium (K) value was 2.477%. In the third treatment group, the nitrogen (N) value was 3.291%, the phosphorus value was 3.082 %, and the Potassium (K) value was 3.135%.
Conclusion: According to the results, the higher the chicken feather fermented fertilizer dose, the higher the NPK content. This is certainly good for the growth of spinach.
The effect of empowerment of the "Mahatta" Cadre on the health status of the first thousand days of birth
Authors: Kamariyah Nurul , Aditya Putri Rahmadaniar , Nurjannah Siti , Umamah Faridah , Indrika Elke Amanda 
Published: March 2024

Introduction: For the past ten years, child malnutrition has been a major national concern in Indonesia. Although the incidence of stunted toddlers has reduced, more than a fifth of toddlers in Indonesia still have stunted growth, making the issue of stunted toddlers a public health concern. This condition got worst due to the COVID-19 pandemic. In Indonesia, the COVID-19 pandemic has hampered access for mothers and children to optimal health services. Thus, This study aims to assess the effect of empowerment of the "Mahatta" cadre on the health degrees ahead of the first thousand days of birth.
Method: The research design was quasi-experimental, with consecutive sampling techniques to determine. The study was conducted in Sampang City. In this study, we divided into two groups. Each group consists of 58 respondents. The intervention group was a group that got empowerment from Mahatta cadres, and the control group was not. The instrument used in this study was a questionnaire sheet. The statistical analysis for the analytic study was man Whitney and Wilcoxon and chi-square. The significant p-value was less than 0.05.
Results: The average age in the intervention group (43.59 ± 7.910 years old) was higher than the control group (42.53 ± 8.236 years old). Our findings show an enhancement of the test result in the control group of Mahatta's health workforce empowerment aspect. The empowerment of Mahatta cadres significantly increases the health status score (p=0.000) in the intervention group. The mean value in the intervention group was even higher than in the control group. This showed the potential for Mahatta cadres to improve the health status of pregnant women and children under two years of age.
Conclusion: The empowerment of Mahatta cadres significantly increases the health status score in the intervention group.
The correlations between insulin administration on hypoxia-inducible factor-1 (HIF-1) and vascular endothelial growth factor- (VEGF-) in experimental rat myocardium experienced hyperglycemia with hypoxia
Authors: Prasetia Toni , Lipoeto Nur Indrawati , Yanwirasti Yanwirasti , Masrul Masrul , Rusmini Hetti 
Published: March 2024

Introduction: Hyperglycemia will lead to the synthesis of endothelium-1, which triggers vasoconstriction, resulting in decreased perfusion and ischemia. This will turn causing hypoxia which can induce hypoxia-inducible factor-1 (HIF-1) to release vascular endothelial growth factor (VEGF). This study aimed to analyze the relationship of HIF-1 expression to VEGF-β in the myocardium of experimental rats experiencing hyperglycemia with hypoxia.
Methods: This research method is purely experimental, all variables are controlled by a post-test only control group design. 30 male Wistar rats aged 3 months with 200–250 g were used. They were divided into two groups using simple random sampling techniques. Before given treatment, blood glucose checks were carried out in both groups. Furthermore, both groups were conditioned to be hyperglycemic and hypoxic for some time. Then, the first group was given insulin while the second group was not given insulin. The expression of HIF-1, VEGF-β was examined using immunohistochemistry. Data analyzed with Spearman test.
Results: The mean blood glucose in the first group was 174 ± 8.80 mg/dl while the second group was 173.67 ± 10.10 mg/dl. The mean value of HIF-1 in the first group was 63.33 ± 24.97% while the second group was 77.33 ± 12.79%. The mean value of VEGF-β in the first group was 37.33 ± 15.80% and in the second group was 13.67 ± 8.76%.
Conclusion: Changes in HIF-1 expression did not have a significant relationship with the expression of VEGF-β, both in control and treatment.
The effect of the type of thyroidectomy on the incidence of hypothyroidism
Authors: Sagiran  , Jaffariz M. Afif , Ardi Pramono  
Published: March 2024

Link of Video Abstract: https://youtu.be/cKF7Miu4D9I

Background: Thyroidectomy is the surgical removal of part or all of the thyroid glands. Thyroidectomy is performed to treat thyroid disease which can be in the form of enlargement of the thyroid glands and thyroid cancer. Thyroidectomy is performed to help cure the patient's disease, but after thyroidectomy, there is still the possibility of post-operative complications. One of the common complications that can occur is hypothyroidism. The type of thyroidectomy surgery that generally results in hypothyroidism is near-total or total thyroidectomy.
Methods: An analytic observational study with a cross-sectional design was carried out at PKU Muhammadiyah Gamping Hospital. A total of 50 people who had thyroid problems or diseases and had undergone thyroidectomy surgery were included in the samples. The inclusion criteria for this study were patients aged 20–80 years, with hyperthyroidism or euthyroidism, both outpatients or inpatients. Patients with hypothyroidism and those with thyroid disease are excluded from this study. The research data were analyzed with the Fisher exact test.
Results: Majority of the sex of subjects in this study were female. Most of the subject age groups in this study were in the 20-50 year age group. Hypothyroid complications occur in 8% of subjects. The results of bivariate analysis obtained a significant value
Pilot study of massive open online course (MOOC) implementation in electrocardiography (ECG) learning: perspectives from general practitioners
Authors: Gharini Putrika Prastuti Ratna , Gumilang Rizki Amalia , Hasana Shofuro , Fatimah Vita Arfiana Nurul , Kokasih Orisativa , Supriami Kelvin , Solikhah Hana Maryam 
Published: March 2024

Link of Video Abstract: https://youtu.be/N3kTT9WiLNw

Background: Cardiovascular disease (CVD) is Indonesia's primary cause of morbidity and mortality. Rapid detection and appropriate treatment of CVD cases are needed to reduce mortality. Electrocardiography (ECG) is a simple examination modality that can detect many cardiac abnormalities. General practitioners are expected to master the interpretation of basic ECG. Massive open online course (MOOC) is a breakthrough that can facilitate profound learning without temporal and physical barriers and support continuing medical education. This pilot study aimed to evaluate the implementation of MOOC in ECG learning among a limited number of general practitioners.
Methods: Consecutive sampling was used to recruit the subjects. Subjects were given ten weeks to finish all modules and quizzes. Pre-test and post-test were taken. User satisfaction was evaluated using a questionnaire. A focused group discussion (FGD) was conducted to explore subjects' learning experiences and perspectives toward the learning system using MOOC.
Results: 17 general practitioners participated in the study, but only seven could finish all the modules and quizzes. All subjects were aged under 30 years old. Those who could complete the course took 10-39 days. Post-test scores were significantly higher than pre-test scores (p=0.038). Although subjects agreed that MOOC was convenient, attractive, and suitable for general practitioners in clinical practice, they demanded an explanation of the quiz answers. They suggested that some modules should be optional.
Conclusion: MOOC learning was suitable for general practitioners to improve their ECG interpretation skills. Some features should be added to increase user satisfaction. A study with extensive subjects is needed to analyze the effectiveness of this ECG course.
The correlation between Anogenital Distance (AGD) and Endometriosis
Authors: Nalley Ricky Ricardo , Abdullah Nusratuddin , Madya Fatmawati , Asni St. Nur , Sriwijaya  , Susiawaty  
Published: March 2024

Link of Video Abstract: https://youtu.be/XmIf_eavZto

Background: Endometriosis is a disease that causes recurrent chronic pain related to menstruation in around 10% of women of reproductive age. However, current non-invasive diagnostic tools are not sufficiently good at detecting endometriosis. Anogenital Distance (AGD) is a new measurement parameter that is non-invasive and proven to be used to help detect endometriosis. This study aims to assess the ability of AGD in detecting endometriosis.
Methods: This study is a diagnostic test study involving 35 endometriosis patients and 35 controls by comparing the clinical characteristics of the patients and the length of AGD-AF and AGD-AC for both groups. Data were analyzed using SPSS version 22.0 for Windows.
Results: The median AGD-AF length in endometriosis patients and controls were 22.65 + 6.54 and 29.53 + 3.52 (p<0.001) respectively, with AGD-AC lengths being 68.04 + 5.8 and 66.81 + 5.49 (p=0.369). In the multivariate logistic regression test, AGD-AF length was a single significant predictor (p <0.001). Based on the ROC curve, the length of AGD-AF with a cut-off of 23.35 mm has a sensitivity and specificity value of 97.1% and 65.7%.
Conclusion: This study states that there is a correlation between AGD and endometriosis, especially AGD-AF, so it can be used as one of the predictors to help detect endometriosis.
Genomic characterization of reinfection cases in the first wave of the COVID-19 pandemic in Indonesia
Authors: Suwarsono Erike Anggraini , Hendarmin Laifa Annisa , Adhiyanto Chris 
Published: March 2024

Link of Video Abstract: https://youtu.be/TRnFAXBESHc

Background: Coronavirus disease 2019 (COVID-19) has become a significant disease causing a pandemic worldwide. Many variants were detected within the globe and may have an important role in transmission capability or reinfection conditions. The ‘unknown’ level of immunity’s protection from previous infection and the more virulent virus could lead to reinfection. Using the whole genome sequence, we can analyze the genomic insight within the first and second infections to help understand the reinfection pattern of COVID-19.
Methods: In this study, we investigated three COVID-19 cases with reinfection for primary and secondary infection each. The SARS-CoV-2 confirmation was conducted using qPCR with multiplex gene targets Orf1ab and E. Confirmation of reinfection was done by genomic analysis. Library preparation and sequencing were done using ARTIC protocol using nanopore technology.
Results: There was a wide variety of mutations between two episodes of infection and different clinical manifestations in each episode.
Conclusions: The result concluded that reinfection happened in worsened clinical symptoms and distinct genomic variation in each episode of infection
The association between postpartum perineal laceration with anatomy and pelvic floor muscle strength
Authors: Gosal Gledies Theresye , Irianta Trika , Lotisna David , Sunarno Isharyah , Farid Imam Ahmadi , Pelupessy Nugraha Utama 
Published: March 2024

Link of Video Abstract: https://youtu.be/lrnQiVZyH8Q

Background: Perineal lacerations damage the tissues around the vagina and rectum and can cause disruption of the anatomy and function of the pelvic floor. The incidence of perineal lacerations after vaginal delivery ranges from 53-89%. This anatomical damage and muscle dysfunction can cause urinary incontinence, anal incontinence, and uterovaginal prolapse. This study aims to evaluate the effects of postpartum perineal lacerations on the anatomy and strength of the pelvic floor muscles.
Methods: The sample of this study is primiparous women who experienced perineal lacerations. Sampling was carried out prospectively using the consecutive sampling method. Pelvic floor anatomy and strength were measured using a POP-Q system and a perineometer. The 1st and 2nd degree laceration group measurements will be compared using the chi-square, and Mann-Whitney tests will be carried out.
Results: Of the 123 research samples that met the criteria, a significant difference was found in the strength of the pelvic floor muscles in the first-degree perineal laceration and second-degree perineal laceration groups at 1st day and 12 weeks postpartum (p = 0.000 and p = 0.042). The only significant difference found for pelvic floor muscle anatomy is in perineal body length at 12 weeks postpartum.
Conclusion: The degree of perineal laceration is related to the strength of the pelvic floor muscles after delivery and the length of the perineal body 12 weeks postpartum.
Correlation between phenotype and cortisol with anxiety status related to Polycystic Ovary Syndrome (PCOS)
Authors: Shulaeha Ummi , Tahir Andi Mardiah , Abdullah Nusratuddin , Sunarno Isharyah 
Published: March 2024

Link of Video Abstract: https://youtu.be/VpTspeX7fe0

Background: Polycystic Ovary Syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. Symptoms include irregular menstrual cycles, hirsutism, obesity, acne vulgaris, and infertility. PCOS is a stigmatized condition that affects women's identity and mental health, especially anxiety. In addition, increased cortisol is associated with increased anxiety. This study aims to determine the effect of phenotype and cortisol on anxiety status in polycystic ovary syndrome (PCOS) patients.
Methods: 40 patients diagnosed with polycystic ovary syndrome (PCOS) aged 18-40 years in Makassar. The Indonesian version of the Hamilton Anxiety Rating Scale (HAM-A) assesses anxiety. A blood sample is taken to check for cortisol (drip blood test). Cortisol levels were measured using the CMIA (Chemiluminescent microparticle Immunoassay) method. Data were analyzed using SPSS version 25.0 for Windows.
Results: The prevalence of phenotypes A, B, C, and D were 27.5%, 0%, 45%, and 45%, respectively. Phenotype C had a higher body mass index than the other phenotypes but was not significantly different. (p > 0.05). About 26.1% of patients with phenotype A were found to suffer from mild anxiety and 29.5% experienced moderate anxiety. Compared to phenotype C, 52.2% experienced mild anxiety and 35.5% experienced moderate anxiety; however, these results were not statistically significant. Higher cortisol levels were found in phenotype A compared to other phenotypes (phenotype C; 7.01±3.12 and phenotype D; 6.37±3.02) but not significantly different (p>0.05).
Conclusion: The PCOS phenotype has no relationship with the anxiety status of PCOS patients and there is no relationship between the phenotype and serum cortisol levels in PCOS patients.
Coil migration during coronary artery fistula transcatheter embolization
Authors: Homenta Rampengan Starry , Kwandou Willis , Pangemanan Janry A. , Jim Edmond L. 
Published: March 2024

Link of Video Abstract: https://youtu.be/qD-dDYr0m2U

Introduction: Coronary artery fistula (CAF) transcatheter coil embolization is very effective in treating symptomatic coronary fistula and has many advantages compared to the surgical approach. Although this procedure is considerably safe, some life-threatening complications, including vessel rupture, coil migration and death, could still happen. We reported an example case of coil migration into the left anterior descending (LAD) artery during transcatheter CAF embolization.
Case Description: A 61-year-old man reported recurrent episodes of typical chest pain and a history of inconclusive exercise tests. Computed tomography (CT) angiography revealed a considerable medium size complex coronary fistula from proximal LAD to main pulmonary artery (MPA), which could cause coronary steal syndrome. The patient then underwent CAF transcatheter coil embolization with 3 pushable coils. Upon delivery of the last coil, the coil suddenly migrated into proximal LAD and made the patient feel chest pain with slight ST depression on electrocardiogram (ECG) monitor lead. This coil migration was treated with a coronary stent to pin the coil into the ostial CAF and coronary vessel wall. After the procedure, the chest pain disappeared, and the ST segment on ECG resolved back to baseline.
Conclusion: Coil migration is one of the potentially life-threatening complications during transcatheter CAF coil embolization. Careful preparation in choosing the closure technique, selecting coil size, determining the landing zone and using a detachable coil in high-risk CAF anatomy is mandatory to prevent this event.
Hemoptysis in COVID-19 pulmonary embolism patient: a case report
Authors: Bur Rika , Gebrina Meutia , Wildani Muhammad Maulana , Rumondor Bayu Bijaksana , Muchtar Yarmaniani Miliati , Talib Suprohaita Rusdi , Dewi Febby Elvanesa Sandra , Maria Gita 
Published: March 2024

Link of video abstract: https://youtu.be/LsOAYx2sZmw

Background: Coronavirus disease 2019 (COVID-19) is related to hypercoagulability and venous thromboembolism (VTE). The overlapping symptoms of COVID-19 linked to acute respiratory distress syndrome (ARDS) and COVID-19 with concomitant pulmonary embolism (PE) provide a diagnostic difficulty for emergency physicians. This case study aims to evaluate the hemoptysis in COVID-19 pulmonary embolism patient.
Case presentation: A 46-year-old woman with COVID-19 complained of a bloody cough (estimated 10 ml). She had COVID-19 five days before presenting. Vital signs were normal, but the respiratory rate went 30 times per minute. A lab test revealed 838.64 ng/ml of D-dimer. A chest x-ray showed bilateral lower lobes opacity. The first HRCT showed consolidation with fibrosis and minimal traction bronchiectasis in the 7th and 8th segment of the right lower lobe, an atypical sign of a COVID-19 lesions. The patient was later hospitalized in a negative pressure chamber, given heparin for 72 hours, and discharged on an oral anticoagulant.
Conclusions: This is one of the first reports of segmental PE in a COVID-19 patient with no VTE risk factor. Emergency care doctors must be aware of the possible link between COVID-19 and PE. Hemoptysis is uncommon in PE patients and is seldom documented in COVID-19 infections. All suspected or confirmed COVID-19 patients should begin thromboprophylaxis to avoid morbidity and death.
Herpes zoster and postherpetic neuralgia progression rate: an epidemiological study at Tertiary Hospital in Bali, Indonesia
Authors: Putra Anak Agung Gede Kresna Naria , Karmila I Gusti Agung Dwi , Ketut Kwartantaya Winaya  
Published: March 2024

Link of Video Abstract: https://youtu.be/bmHkb4pnp9I

Background: Herpes zoster is an infectious disease caused by the reactivation of the latent varicella zoster virus. One of the complications that has the potential to cause long-term problems is post-herpetic neuralgia. This study aims to evaluate the Herpes zoster and postherpetic neuralgia progression rate: an epidemiological study at Tertiary Hospital in Bali, Indonesia
Methods: This is a retrospective descriptive cross-sectional study. The data was obtained from the patient's medical records in Dermatovenereology Clinic at Sanglah General Hospital Denpasar from January 2020 to December 2021. The samples were all new patients diagnosed with herpes zoster and post-herpetic neuralgia. The variable is sex, age, occupation, comorbid, and location. Data were analyzed using SPSS version 25.0 for Windows.
Results: A total of 23 new patients were diagnosed with herpes zoster and the total visit was 132. Most patients were male 12 (52.3% vs 47.7%). The highest age group was more than 65 years old with 12 (51.5%) patients, followed by 45-64 years with 8 (35.6%) patients. The lesion location in most patients was thoracic in 9 patients (38.1%), followed by cervical in 7 patients (29.5%), lumbar in 6 patients (25.8%), and ophthalmic in 1 patient (6.6%). Six patients (26.0%) had comorbid diseases. Ten patients experienced PHN.
Conclusion: Most herpes zoster patients in Dermatovenereology Clinic, Sanglah Hospital from January 2020 to December 2021 were more than 65 years old, predominantly male sex, with the most common location of herpes zoster in the thoracic region 9 patients (38.1%), and 10 patients (43.5%) had PHN.