bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparations of efficacy and safety of rituximab, calcineurin inhibitors and cyclophosphamide in primary membranous nephropathy: a single-center retrospective analysis
Authors: Lu Luying , Zhu Huayan , Cai Shasha , Liu Guangjun , Wang Yaomin , Ren Pingping , Lan Lan , Shen Xiaoqi , Chen Liangliang , Xu Ying , Cheng Jun , Li Xiayu , Chen Jianghua , Han Fei 
Published: February 2024

Abstract

Background Rituximab (RTX), calcineurin inhibitor (CNI) and cyclophosphamide (CTX) plus glucocorticoids are first-line therapeutic options for primary membranous nephropathy (PMN).
Methods Totally 478 biopsy-proven PMN patients in single center were retrospectively included. After 1:1 propensity score matching (PSM), 258 patients were included in RTX, CNI or CTX group (86 patients in each group).
Results After PSM, there were no differences on serum creatinine, eGFR, serum albumin, urine protein, anti-PLA2R antibody among groups. The follow-up duration was 12 (10.5, 18) months in CNI group, 12 (12, 18) months in CTX group and 12 (12, 18) months in RTX group. Throughout entire follow-up period, 39 patients (45.3%) in CNI group, 47 patients (54.7%) in CTX group, and 59 patients (68.6%) in RTX group achieved composite response (complete remission and partial remission). The survival curve showed a higher composite response in RTX group than CNI group (p=0.018). A relapse occurred in 15 of 39 (38.5%) patients in CNI group, significantly higher than CTX group (4.3%, p<0.001) and RTX group (3.4%, p<0.001). In CNI group, 36% patients had a ≥25% decline in eGFR, and 15.1% of patients had a ≥50% decline in eGFR.
Conclusions RTX may be more effective than CNI in inducing remission in PMN and showed similar efficacy to CTX. CNI may have a high risk of proteinuria relapse and eGFR decline.
Integrated Analysis of Remote Sensing with Meteorological and Health Data for Allergic Rhinitis Forecasting in Tianjin
Authors: guo yudi , wang Yuan , Fan Wenyan , Li Gen 
Published: February 2024

Abstract

Long time series of vegetation monitoring can be carried out by remote sensing data, the level of urban greening is objectively described, and the spatial characteristics of plant pollen are indirectly understood. Pollen is the main allergen in patients with seasonal allergic rhinitis. Meteorological factors affect the release and diffusion of pollen. Therefore, studying of the complex relationship between meteorological factors and allergic rhinitis is essential for effective prevention and treatment of the disease. In this study, we leverage remote sensing data for a comprehensive decade-long analysis of urban greening in Tianjin, focusing on its impact on allergic rhinitis through changes in pollen distribution. Utilizing high-resolution imagery, we quantify changes in urban Fractional Vegetation Coverage (FVC) and its correlation with pollen types and allergic rhinitis cases. Our analysis reveals a significant correlation between FVC trends and pollen concentrations, highlighting the influence of urban greenery on allergenic pollen levels. We establish a robust connection between the seasonal patterns of pollen outbreaks and allergic rhinitis consultations, with a noticeable increase in consultations during high pollen seasons. our findings indicate a higher allergenic potential of herbaceous compared to woody vegetation. This nuanced understanding underscores the importance of pollen sensitivity, alongside concentration, in driving allergic rhinitis incidents. Employing a generalized linear model, we develop a predictive framework for allergic rhinitis consultations, integrating remote sensing, meteorological, and health data. The model demonstrates high predictive accuracy, particularly in summer and autumn, offering a novel approach for anticipatory healthcare in urban environments. Overall, our study pioneers the integration of remote sensing with meteorological and health data for allergic rhinitis forecasting. This integrative approach provides valuable insights for public health planning, particularly in urban settings, and lays the groundwork for advanced, location-specific allergenic pollen forecasting and mitigation strategies.
Comparison of Intradermal Irritation based on Poly(methyl methacrylate) Hydrogel
Authors: Racheal Christianah 
Published: February 2024

Abstract
To investigate the potential skin irritation response of domestically produced medical poly(methyl methacrylate) hydrogel, the intradermal injection method was used. Healthy white rabbits were selected for intradermal injection of 0.5% sodium chloride solution as a control, 0.5% sodium chloride extract, and olive oil extract for the test samples. The rabbits were observed for erythema and edema at 24 and 72 hours, and the primary irritation index was calculated. The primary irritation index of the domestically produced poly(methyl methacrylate) hydrogel was 0, indicating no skin irritation response.
Emerging Topological Multiferroics from the 2D Rice-Mele Model
Authors: Vergara Patricio , Saez Guidobeth , Castro Mario , Allende Sebastian , Nunez Alvaro 
Published: February 2024

Abstract
We introduce a novel two-dimensional dimerized lattice model that reveals a remarkable feature: the emergence of a complex, nontrivial topological multiferroic phase marked by zero Berry curvature and a significant Berry connection that influences the model's bulk topology. This model extends the one-dimensional Rice-Mele Hamiltonian model to explore polarization-dependent topological properties in a 2D Su-Schrieffer-Heeger lattice, providing a detailed framework for studying the impact of symmetry-breaking and spatially varying potentials on electronic and spin properties. The findings are particularly relevant for spintronics, offering a foundation for topologically robust and electrically controlled spin-conducting edge states, with implications for developing advanced spin-dependent transport devices.
A Generalized Bouc-Wen Model for Simulating the Quasi-Static and Dynamic Shear Responses of Helical Wire Rope Isolators
Authors: Capuano Raffaele , Vaiana Nicolò , Carboni Biagio 
Published: February 2024

Abstract

This research investigates the mechanical behavior of a helical wire rope isolator deforming along its shear direction. In particular, we present the results of an extensive experimental campaign including both quasi-static and dynamic tests. The former provide hysteresis loops characterizing the device quasi-static behavior; the latter, performed by using an electro-mechanical shaker, furnish frequency response curves describing the dynamic behavior of a rigid block supported by the tested device. To simulate such a complex behavior, we adopt a generalized Bouc-Wen model and identify its parameters on the basis of the quasi-static test results. Subsequently, such a model is employed to reproduce the frequency response curves of the isolated rigid block. Since the results of the dynamic tests suggest the presence of rate-dependent hysteresis phenomena in the isolated system, the generalized Bouc-Wen model is enhanced by introducing a linear viscous component. Finally, to substantiate the model validation, the experimental results obtained by applying a series of white noise signals are compared with those obtained numerically to demonstrate the model capability of reproducing the device behavior in non-stationary response conditions.
PET-MR Guided, Pre-targeted delivery to HER2(+) Breast Cancer Model
Authors: Si Ge , Hapuarachchige Sudath , Lesniak Wojciech , Artemov Dmitri 
Published: February 2024

Abstract
Purpose: HER2(+) metastatic breast cancer (mBC) is one of the most aggressive and lethal cancer types among females. While initially effective, targeted therapeutic approaches with trastuzumab and pertuzumab antibodies and antibody-drug conjugates (ADC) lack long-term efficacy against HER2(+) mBC and can cause severe systemic toxicity due to off-target effects. Therefore, the development of novel targeted delivery platforms that minimize toxicity and increase therapeutic efficacy is critical to the treatment of HER2(+) breast cancer (BC). A pretargeting delivery platform can minimize the non-specific accumulation and off-target toxicity caused by traditional one-step delivery method by separating the single delivery step into a pre-targeting step with high-affinity biomarker binding ligand followed by the subsequent delivery step of therapeutic component with fast clearance. Each delivery component is functionalized with bioorthogonal reactive groups that quickly react in situ, forming cross-linked clusters on the cell surface, which facilitates rapid internalization and intracellular delivery of therapeutics.
Procedures: We have successfully developed a click chemistry-based pretargeting platform for HER2(+) BC enabling PET-MR image guidance for reduced radiation dose, high sensitivity, and good soft tissue contrast. Radiolabeled trastuzumab and superparamagnetic iron-oxide carriers (uSPIO) were selected as pretargeting and delivery components, respectively. HER2(+) BT-474 cell line and corresponding xenografts were used for in vitro and in vivo studies.
Results: An enhanced tumor accumulation as well as tumor- to-organ accumulation ratio was observed in pretargeted mice up to 24 h post uSPIO injection. A 40% local T1 decrease in the pretargeted mice tumor was observed within 4 h, and an overall 15% T1 drop was retained for 24 h post uSPIO injection.
Conclusions: Prolonged tumor retention and increased tumor-to-organ accumulation ratio provided a solid foundation for pretargeted image-guided delivery approach for in vivo applications.
Co-cultivation of Lipomyces starkeyi and Acinetobacter baylyi for the production of microbial lipids from lignocellulosic hydrolysates
Authors: Subramaniam Ramalingam , Chistoserdov Andrei 
Published: February 2024

Abstract
The growth of Acinetobacter baylyi and Lipomyces starkeyi was investigated individually and in a co-culture in a minimal medium (MM) in the presence of vanillin, syringaldehyde, para-hydroxybenzaldehyde (PHB), furfural and hydroxymethylfurfural (HMF), to understand the growth and lipid accumulation capability. The MM, which was developed in our laboratory, significantly reduced the medium cost for lipid production by L. starkeyi from $12.68 per gallon lipids to $3.11 per gallon lipids with the carbon source representing the remaining major cost factor. A. baylyi failed to grow in the MM but grew in the modified Suutari medium (MSM). L. starkeyi showed a decreased growth in the presence of a mix of 0.1 g/L and 0.25g/L of furfural, HMF, PHB, vanillin, and syringaldehyde in comparison to the growth in the MM without these inhibitors and completely failed to grow when they were present at the 0.5 g/L concentrations. The co-culture of L. starkeyi and A. baylyi in the MM resulted in the maximum cell concentration and lipid production of 9.72 g/L and 5.04 g/L; 9.72 g/L and 4.90 g/L; and 9.24 g/L and 4.65 g/L for the initial inhibitor concentrations of 0.1 g/L; 0.25 g/L and 0.5 g/L, respectively. Almost complete consumption of the inhibitors was observed when they were added at 0.1 g/L and 0.25 g/L concentrations. However, at initial inhibitor concentrations of 0.5 g/L, the inhibitors were first taken up but then released back into the media when the co-culture reached the stationary phase.
Evaluation of INSAT 3DR Sounder derived Wind Index using Radiosonde Observation over India
Authors: Singh Neeti , Vinayak Munn , Lohan Nitin , Mitra A. k. , Giri Ram Kumar 
Published: February 2024

Abstract

Rapid advancements in the field of forecasting demand in-depth study spanning wind-derived products and other several climate fields. The wind index is one of the most valuable parameters and shows significant changeable and intermittent over a range of timescales since it is weather-dependent. Therefore, accurate wind index observation is acknowledged as a vital contribution to trustworthy large-scale Thunderstorm forecasts. This remote-sensing information is associated with errors and needs to be validated. In the current investigation, in situ, ground-based radiosonde data have been used to evaluate Infrared (IR) sounder data onboard the Indian navigation satellite (INSAT-3DR) satellite. It is discovered that the outcomes rather closely match the satellite data's unfavorable skew. There is a demand for this study that needs to be done on larger domains and data sets. All of India's different stations are considered and 2022, 2021, and 2020 data are analysed. Furthermore, this paper emphasizes the Wind Index accuracy for helicopter operation. However, wind index information is derived by satellite but always missing by Radiosonde. The proposed method is applied to the estimating Radiosonde wind index. This study mainly focuses on calculating wind index from different radiosonde parameters and then validating INSAT 3DR with Radiosonde WI.
Traceability for Strengthening Supply Chain Systems and Enhancing Real-Time Visibility: Focus of NAFDAC on Advancing Vaccines Traceability in Nigeria
Authors: Adeyeye Mojisola , Kayode John , OLASUPO Sabitu 
Published: February 2024

Abstract
This study explores the successful implementation of activities aimed at scaling traceability for COVID-19 and Routine Immunization (RI) vaccines to the Local Government Level (LGA) and selected Healthcare facilities in Nigeria, funded by the Bill and Melinda Gates Foundation. The study was executed by the National Agency for Food and Drug Administration and Control (NAFDAC) and sought to enhance supply chain systems by deploying advanced traceability mechanisms, underscoring product monitoring, and ensuring real-time stock visibility. The inquest discusses the accomplishments, challenges, and regulatory framework of NAFDAC, emphasizing GS1 Technology-driven Traceability, and presents the outcome of the field scanning activities conducted in July 2023. The study utilized GS1 standards to uniquely identify products, locations, and personnel in the supply chain. The approach involved a phased public sector pilot, showcasing the feasibility and challenges of tracking vaccine movement through the supply chain. The result shows the detection of 43 unique products across 1022 facilities from a total of 110,113 scans, offering valuable insights into vaccine distributions. The strategic goals of the project aligned with developing safety surveillance systems in Low- and Middle-Income Countries (LMICs) to facilitate patient access to global health products. The safety surveillance initiative complemented ongoing global efforts among WHO-HQ, PAHO, ASEAN, and MHRA, underlining safety systems across regions. Similarly, a significant improvement in traceability through automated data capture (barcode scanning) and expanded coverage for COVID-19 and selected RI vaccines in Nigeria was recorded. Summarily, information derived from this report will build confidence in patients regarding vaccine authenticity, establish a transparent and robust supply chain, and foster pharmacovigilance capability through integration with the track-and-trace systems. Thus, the study provides invaluable insights and opportunities for global health practitioners, policymakers, and researchers. Convincingly, this script will also serve as a reliable blueprint and innovative model for incorporating track-and-trace into regulatory oversight by other National regulatory authorities, most especially in Low- and Middle-Income Countries.
Antagonist of CD39 and CD73 potentiate Doxycycline repositioning to induce potent antitumor immune response
Authors: DALAI PARAMESWAR , Shah Dhruvi , Soni Kinal , Shah Jigna , Desai Chirag , Thanki Kavya , Agrawal-Rajput Reena 
Published: February 2024

Abstract
Purpose
Studies have reported that cellular metabolism at tumor-immune microenvironment (TiME) serve as a critical checkpoint and perturbs/supports anti-cancer immunity. Extracellular ATP (eATP) may mediate anti-cancer immune response however; its catabolism by ectonucleotidase generates immunosuppressive adenosine. Antagonist of ectonucleotidases: CD39 and CD73 have been explored as potential therapeutic. In the presented work we have tried to repurpose doxycycline for mitigating ATP metabolism with or without antagonist of ectonucleotidase.
Methods
eATP and adenosine level were quantified. The bone marrow-derived M1 and M2 polarized macrophages were maintained in tumor mimicking condition (TMC). Total or CD4+ Tcells were co-cultured with macrophages to understand the impact of doxycycline and antagonist of ectonucleotidase T cell/subset differentiation. Preclinical efficacy of doxycycline and ectonucleotidase antagonist and their synergy was scored in 4T1 breast carcinoma.
Results
Doxycycline manipulates macrophage polarization by decreasing the frequency CD206+M2 macrophages that promoted CD4+ directed CD8+ T cell mediated tumor cell lysis. Doxycycline alleviated the expression of CD39 and CD73, rescuing ATP catabolism. Doxycycline delayed tumor growth by enhancing F4/80+ CD86+ M1 macrophages and subsequently anti-tumor Tbet+ CD4+ T-cells, attenuating the frequency of FOXP3+ regulatory T cells which was cooperatively supported by ARL67156 and AMPCP (CD39 and CD73 antagonist). Doxycycline promoted CD8+T cell mediated cytotoxicity which was synergistically enhanced with ARL67156 and AMPCP ensuring a possibility of using doxycycline alone or in combination with antagonist of ectonucleotidase.
Conclusion
Presented data indicate a prospective usage of doxycycline as novel immune checkpoint blocker (ICB) against ectonucleotidase and may be modified/delivered appropriately as a sole ICB.
Heparinase III cleaved HS promotes vasculogenic mimicry in Triple Negative Breast Cancer via VEGFA signaling
Authors: Chen Xinjie , Kong Weijia , Zhang Ganlin , Sun Xu , Xie Ying , Wang Xiaomin 
Published: February 2024

Abstract
Anti-angiogenic therapy sometimes triggers alternative vasculogenic mimicry, which is a predictor of poor prognosis. Researches on angiogenesis and vasculogenic mimicry double-related targets and the mechanism behind them could help with this dilemma. The interaction between HS and growth factors in the extracellular matrix can affect various biological behaviors of cells, including tumor cells. Heparinase III from Flavobacterium heparin is an enzyme primarily degrading heparan sulfate (HS). Using heparinase III and HS degeneration inhibitor OGT2115 as regulators, we found that HS-cleaved triple-negative breast cancer cells were more capable of obtaining blood supply by enhanced angiogenesis and vasculogenic mimicry formation. Further studies showed that this effect was achieved by affecting the affinity between HS and VEGFA because HS functions as a co-receptor of VEGFA and induces a stronger signal response by heparinase III exposed neo-epitope. Our work shows for the first time that cleaved heparan sulfate is able to promote VM formation and comes up with a combination of heparinase inhibitors or HS mimetics with anti-angiogenic agents or VEGFR2 inhibitors will be a promising tumor treatment strategy.
From Legislation to actual Health Service: Evaluation of Health Provisions in the Disability Law of Ghana by Children with Disabilities and their Families
Authors: Gyimah Ebenezer Mensah , Dassah Ebenezer , Opoku Maxwell Peprah , Ntoaduro Afua , Ampratwum Joseph , Tutu Clement Osei , Opoku Cecilia , Zakia Issaka 
Published: February 2024

Abstract
Background: Despite Ghana's Persons with Disability Act, 2006 (Act 715) making provisions for access to healthcare services for Children with Disabilities and their families, corpus of literature has reported that persons with disabilities continue to face challenges in accessing the healthcare services. However, the voices of children with disabilities and their families are very scare in such discourse. This study explored the experiences of children with disabilities and their families in accessing healthcare services as per the provisions described in Ghana’s Act 715. The study attempted to connect legal provisions to experiences of families and children in accessing healthcare.
Methods: This qualitative study involved 45 participants, including 25 children with disabilities and 20 family members from a municipality in Ghana. Employing a phenomenological design, semi-structured interviews were conducted which was then analyzed thematically and interpreted using Critical Disability Theory.
Results: The study identified two major categories of barriers to healthcare access: environmental (socio-economic difficulties, poor built environment, unavailability of rehabilitation services) and systemic (cultural beliefs, poor support at healthcare facilities and inadequate healthcare legislative provisions for families of children with disabilities). Despite legal provisions for free healthcare, participants faced significant financial barriers, with specialist services often not covered by the National Health Insurance Scheme. Poor infrastructure and cultural beliefs also impeded access, while healthcare workers' indifferent attitudes and disrespect further compounded these challenges.
Conclusions: The study reinforces the principles of Critical Disability Theory, emphasizing the importance of upholding individual rights, echoing marginalized voices, appreciating diversity, and fostering independence in healthcare access. The study further calls for policy adjustments to fully cover specialist care under Ghana's National Health Insurance Scheme, establishment of district-level health assessment and resource centers, educational campaigns to change cultural perceptions, and training of healthcare workers to promote quality access to healthcare.
A systematic review of the clinical treatment of patients with fecal incontinence by artificial anal sphincter
Authors: Wang Minghui , Zhou Wei , Liu Ji , Liao Yucheng , Liu Bolin , Yu Hongliu 
Published: February 2024

Abstract

BACKGROUND: This study aimed to evaluate and compare the safety and efficacy of artificial anal sphincters in clinical practice.
Methods: A systematic review of articles in PubMed, MEDLINE, EMBASE, Web of Science, and the Cochrane Library was performed. The literature was reviewed three times by several independent investigators, resulting in the identification of 53 studies that met the criteria. The primary outcomes of interest included: adverse events, incontinence assessment, quality of life assessment, and anorectal manometry.
RESULTS: A total of 12 postoperative complications related to the implantation of the different artificial anal sphincters were reported. Seven different incontinence rating scales and four quality of life scales were used to assess patients' fecal incontinence and improvement in quality of life. A total of 29 studies measured changes in patients' anorectal pressure before and after surgery.
CONCLUSIONS: In terms of safety, the GK, SK, and MAS are simpler devices that cause less damage during implantation and have additional advantages over the AMS800, AN, PAS, and AAB. In terms of therapeutic efficacy, the AN, which is currently the most widely used, is technologically mature and has the best results, while the other artificial anal sphincters have also shown significant improvement in fecal incontinence.
A pediatric case of cat scratch disease complicated by meningitis diagnosed by Metagenomic Next-generation Sequencing
Authors: Jin Li , Wen Yang , Wang Yanjing , Liu Lu , Li Yiyuan 
Published: February 2024

Abstract
Background
While the clinical manifestations of cat scratch disease (CSD) can vary, the occurrence of meningitis in CSD patients is rare. Here we present a case of CSD complicated by meningitis associated with Bartonella henselae (B. henselae).
Case presentation:
An 11-year-old child developed prolonged fever, accompanied by a mild cough and headache. Metagenomic next-generation sequencing identified B. henselae in the blood, and meningitis was confirmed through cerebrospinal fluid analysis. The patient was diagnosed with CSD complicated by meningitis and recovered after receiving antibiotic and prednisone therapies.
Conclusion
For children with CSD presenting with neurological symptoms, the presence of CSD meningitis must not be overlooked.