bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment of invasive thymoma with pleural dissemination
Authors: Ichinose Yukito , Ohta Mitsuo , Yano Tokujiro , Yokoyama Hideki , Asoh Hiroshi , Hata Kazuo 
Published: February 2007

AbstractThe outcome of eight patients with invasive thymoma accompanying pleural dissemination was investigated. Only two patients had mediastinal tumor resection and pleural disseminated tumor excision. Seven patients underwent radiotherapy to the mediastinum and/or disseminated tumors. A clinical response to radiotherapy was achieved in the six patients with evaluable lesions (complete response in five patients and partial response in one). The estimated 5‐year survival rate was 87.5%. Four patients were alive more than 10 years. So far, the mediastinal tumors of seven patients have been controlled for periods ranging from 42 to 154 months. Recurrence in six patients appeared as pleural tumors. Four out of the six patients had five courses of radiotherapy to the recurrent pleural tumors, four of which achieved complete response. No distant metastases were observed at any time. These observations suggest that radiotherapy should be the primary mode of treatment in cases of invasive thymoma with pleural dissemination. © 1993 Wiley‐Liss, Inc.
Salivary duct carcinoma
Authors: Kumar Rekha V. , Kini Lata , Bhargava Asha K. , Mukherjee Geetashree , Hazarika Digantha , Shenoy Ashok M. , Anantha N. 
Published: February 2007

AbstractSalivary duct carcinoma is an uncommon malignant tumor that occurs mainly in the parotid gland of elderly men. The 11 cases of salivary duct carcinoma which are included in this study occurred in older men (mean age 56 years) and were located in the parotid (7), submandibular salivary gland (2), and the minor salivary glands in the maxilla (2). The maximum tumor dimension ranged from 3 to 9 cm. Microscopically, all had infiltrating margins, with circumscribed groups of epithelial cells arranged in various patterns; the invasive component was embedded in a desmoplastic stroma. Perineural invasion and lymph node metastasis were noted in seven and three cases, respectively, at the time of initial surgery. Radical surgery was offered to ten patients and postoperative radiotherapy to nine patients. Salivary duct carcinoma appears to be an aggressive tumor with distinctive histological features, which has not been described in the minor salivary glands of the maxilla to date. The clinicopathologic features of these tumors are presented, with a review of the literature. © 1993 Wiley‐Liss, Inc.
C‐myc oncogene expression: A marker for females at risk of breast carcinoma
Authors: Hehir Dermot J. , McGreal Gerald , Kirwan William O. , Kealy William , Brady Michael P. 
Published: February 2007

AbstractIn an attempt to identify patients at risk of breast cancer, 9E 10 c‐myc monoclonal antibody was used to detect the oncogene products in 64 breast tissue biopsies. There were 44 specimens of benign breast disorders: 21 from patients who developed subsequent breast cancer, and 23 from patients who did not. The remainder were malignant tumor biopsies from those who developed breast cancer. C‐myc over‐expression was identified in 12 (60%) of the breast carcinomas; it was also noted in 13 (62%) of the benign biopsies from patients who developed subsequent breast carcinoma. Expression was observed in only 3 (13%) controls—patients who did not develop cancer. A prospective study is now warranted to determine the clinical usefulness of our findings. © 1993 Wiley‐Liss, Inc.
Lumbosacral chordoma resection: Image integration and surgical planning
Authors: Stephens G. Christopher , Schwartz Herbert S. 
Published: February 2007

AbstractClinical, radiographic, and functional outcome parameters were analyzed before and after treatment of eight individuals with lumbosacral chordomas studied over a 3‐year period. Emphasis was placed upon correlation of multiplane images and the pathoanatomy of the gross specimen. Surgical resections achieving wide margins can be curative. Magnetic resonance imaging of lumbosacral chordomas has revolutionized the preoperative anatomic localization of these tumors. Therefore, it is critical that the operating surgeon scrutinize the three‐dimensional location of the tumor and its spatial relationship to surrounding structures prior to surgical eradication. A systematic approach for the radiographic analysis of tumor extent in lumbosacral chordomas is presented. Four strategic areas of preoperative analysis are identified for sacral chordomas and two for lumbar neoplasms. Functional outcome after resection is predicted by Stener's work. Contamination‐free surgery is facilitated by accurate preoperative radiographic interpretation of the pathoanatomy by the surgeon. © 1993 Wiley‐Liss, Inc.
Tumor progression accompanied by increase in proliferation rate in breast cancer: A preliminary report
Authors: Sasa Mitsunori , Komaki Kansei , Tsuzuki Hideo , Kamamura Yoshitaka , Mori Toshiaki , Miki Hitoshi , Uyama Tadashi , Morimoto Tadaoki , Monden Yasumasa 
Published: February 2007

AbstractForty consecutive cases with invasive ductal carcinoma of the breast (samples of both the primary invasive area and the involved node were available for 19 cases, multiple sections of breast tissue including both the primary invasive area and forefront intraductal cancerous area were available for 15 cases; and multiple sections of breast cancerous tissue and the involved node were available for six cases) were examined by immunohistochemical analysis for evaluation of their proliferation rate. In this study, we selected the PCNA index as a marker of the proliferation rate of the tumor cells. We demonstrated that the PCNA index of the primary invasive area was significantly higher than that of the forefront intraductal area (P – 0.0017), and the PCNA index of the involved nodes was significantly higher than that of the primary invasive area (P = 0.0004). These preliminary findings suggest that the progression from the tumor cells of the intraductal cancerous area to the metastatic tumor cells must be accompanied by two phases of increase in the proliferation rate. © 1993 Wiley‐Liss, Inc.
Gastric cancer in young adults: Growth accelerating effect of pregnancy and delivery
Authors: Furukawa Hiroshi , Iwanaga Takeshi , Hiratsuka Masahiro , Imaoka Shingi , Ishikawa Osamu , Kabuto Toshiyuki , Sasaki Yo , Kameyama Masao , Ohigashi Hiroaki , Nakamori Shoji 
Published: February 2007

AbstractThe relationship between pregnancy and/or delivery (p&d) and the stage of gastric cancer was studied in 64 female and 57 male patients aged 34 or younger with gastric cancer. Gastric cancer diagnosed within 2 years after p&d (group A, 20 patients) was more progressive (unresectable in 20%) than those of the other young female patients with children (group B, 24 patients; 5%) or without children (group C, 20; 0%), or young male patients (group D, 57; 3%) (P < 0.05). The 5‐year survival rate in group A (60.0%) was lower than in group B (83.3%) and group C (85.0%) (P < 0.05 between groups A and B). There were no differences in the duration from the onset of subjective symptoms to diagnosis in the four groups. Out of eight patients who were pregnant after gastrectomy for stomach cancer, one died from recurrence immediately after abortion. These results suggest that pregnancy and/or delivery in young females accelerates the growth of stomach cancer. © Wiley‐Liss, Inc.
Growing teratoma syndrome
Authors: Tongaonkar Hemant B. , Deshmane Vinay H. , Dalal Amish V. , Kulkarni Jagdeesh N. , Kamat Murali R. 
Published: February 2007

AbstractGrowing teratoma syndrome is the term applied to enlarging retroperitoneal or other metastatic masses containing mature teratoma during chemotherapy for nonseminomatous germ cell tumors. Four cases of the growing teratoma syndrome are presented, the metastatic masses being in the retroperitoneum in all the cases. All these patients had enlarging retroperitoneal masses in the presence of normal serum biomarkers following chemotherapy for nonseminomatous tumors. Surgical excision was carried out in all four patients, with disease free survivals ranging from 6 to 24 months after surgery. © Wiley‐Liss, Inc.
Frequent K‐ras mutations and absence of p53 mutations in mucin‐producing tumors of the pancreas
Authors: Hoshi Tomokazu , Imai Masato , Ogawa Katsuhiro 
Published: February 2007

AbstractMucin‐producing tumors of the pancreas (MPT) are characterized by the prodcution of much mucin and a benign course after surgical treatment. We examined 16 cases of MPT and 20 cases of “common” pancreatic duct cell carcinomas (DCC) in regard to K‐ras and p53 mutations. The mutations were detected by constant denaturant gel electrophoresis in combination with other techniques using PCR products amplified from the samples microdissected from the tissue sections. K‐ras codon 12 mutations were identified in all MPT and in 95% of DCC. On the other hand, p53 mutations were found in four of 20 (20%) DCC, and p53 was immunocy‐tochemically overexpressed in 3 of the 4 mutated cases. However, no p53 mutations and no p53 overexpression were identified in the 16 MPT. These results indicate that, although the K‐ras codon 12 mutations may be almost essential for the development of both MPT and DCC, p53 mutations seemed to be involved mainly to the latters. © Wiley‐Liss, Inc.
Cardiac metastasis of liposarcoma
Authors: Papa Moshe Z. , Shinfeld Amy , Klein Ehud , Greif Franklin , Ben‐Ari Gur 
Published: February 2007

AbstractThe authors describe a retroperitoneal liposarcoma with secondary involvement of the left ventricle. Therapy has been disappointing, and is guided by the nature of the primary tumor, previous therapy, extent of metastatic spread, and feasibility of cardiac resection. In selected patients whose primary tumor is well‐controlled and progressing slowly, with no evidence of widespread disease, resection of the cardiac metastases can be performed when technically feasible.
Chemotherapy as predictor of compliance
Authors: Jacobs John R. , Casiano Roy R. , Schuller David E. , Pajak Thomas F. , Laramore George E. , Al‐Sarraf Muhyi 
Published: February 2007

AbstractPatient compliance with the increasingly complex adjuvant therapy protocols has always been of concern, particularly in the head and neck cancer population. The Head and Neck Intergroup recently concluded a phase III prospective randomized trial testing the addition of three courses of cisplatinum containing combination chemotherapy to standard treatment defined as surgery and postoperative radiotherapy for advanced stage III and IV squamous cell carcinoma. The chemotherapy was administered following the surgery prior to the postoperative radiotherapy. Variation from protocol is ranked retrospectively as minor acceptable, major acceptable, and major unacceptable. The incidence of major unacceptable variation from the protocol for radiotherapy immediately following the surgery was 15% vs. 19% in the population that completed all three courses of the chemotherapy (P < 0.10). However, for those patients that completed less than the three courses of chemotherapy, the incidence of major unacceptable variation in radiotherapy was 33% (P < 0.001). This observation was controlled for site, stage, performance status, age, sex, surgical margins and experience of participating institution. We conclude that compliance with a multicourse adjuvant chemotherapy regimen is predictive of subsequent compliance to radiotherapy in the head and neck cancer population. © Wiley‐Liss, Inc.
Selective depression of T‐lymphocyte subsets in gastric cancer patients: An implication of immunotherapy
Authors: Lee Wei‐Jei , Chang King‐Jen , Lee Chue‐Shue , Chen Kai‐Mo 
Published: February 2007

AbstractThe lymphocytes and their subsets were determined in the peripheral blood of 62 gastric cancer patients and 68 controls using fluorescent conjugated monoclonal antibodies and flow cytometry (FACScan method). A significant increase in the total number of white blood cells from gastric cancer patients was noted in comparison to controls, but the percentage of lymphocytes was the same. The percentage of suppressor (cytotoxic) T cells (CD8) showed no difference in all stages of gastric cancer patients evaluated, but the percentage of helper (inducer) T cells (CD4) and the CD4/ CD8 ratio decreased significantly in the advanced stages III and IV. Depression of the CD4/CD8 ratio was well correlated with tumor invasion, lymph node metastasis, and tumor size but not with sex, age, tumor location, gross type, or histologic differentiation. It appeared that the immune defect of gastric cancer patients was associated with the afferent arm (CD4) and worsened as the disease advanced. These results suggest that immunotherapy to stimulate the deficient immune system may play an important part in the multimodality treatment of patients with advanced gastric cancer. © Wiley‐Liss, Inc.
Alteration of tumorigenicity in undifferentiated thyroid carcinoma cells by introduction of normal chromosome 11
Authors: Yoshida Akira , Asaga Tarou , Masuzawa Chihiro , Kawahara Satoru 
Published: February 2007

AbstractThe tumorigenicity of various cell lines has been shown to be suppressed by the introduction of chromosome 11 and other chromosomes via micro‐cell‐mediated chromosome transfer. In this study, we investigated whether a human undifferentiated thyroid carcinoma cell line, TTA‐1, was suppressed by the introduction of normal human chromosome 11 or 10. Chromosome 10 or 11 was transferred from A9 cells containing a single human chromosome 10 or 11 tagged with pSV2‐neo plasmid DNA into TTA‐1 cells, by microcell fusion. The tumorigenicity of the TTA‐1 cells and their colony‐forming efficiency in soft agar were suppressed by chromosome 11, but not by chromosome 10. These results suggest that normal human chromosome 11 carries a putative tumor suppressor gene that affects the tumor‐associated phenotypes of TTA‐1 cells. © Wiley‐Liss, Inc.
Testicular cytotoxicity of intravenous methotrexate in rats
Authors: Johnson Frank E. , Farr Susan A. , Mawad Maurice , Woo Young C. Sun 
Published: February 2007

AbstractAlthough the testicular cytotoxicity of methotrexate has been evaluated in the rat, previous models have utilized routes other than the intravenous one, and have generally employed multiple‐dose regimens. In this report, we describe testicular toxicity in the Sprague‐Dawley rat following a single intravenous bolus of methotrexate (0‐700 mg/kg body weight [BW]), with necropsy 56 days later. Testicular toxicity was evaluated qualitatively by histology and quantitatively by testicular weight, sperm head count, modified Johnsen score, repopulation index, and epididymal index. Effects of methotrexate on heart, lung, liver, and kidney histology were evaluated qualitatively. Oligospermia occurred at low and intermediate dosages of methotrexate, but testicular atrophy was not observed. LD50 at day five for methotrexate appears to be approximately 300 mg/kg BW using this regimen. This model will facilitate the study of techniques to avoid drug‐induced testicular damage. © Wiley‐Liss, Inc.
Renal cell carcinoma producing α‐fetoprotein (AFP) with a unique lectins‐affinity profile
Authors: Minamoto Toshinari , Kitagawa Masanobu , Amano Naoko , Tsukada Yutaka , Hirose Tatsuo , Mai Masayoshi 
Published: February 2007

AbstractRenal cell carcinoma (RCC) producing α‐fetoprotein (AFP) is a rare entity and merely 7 cases have been reported so far. The present case, a 71‐year‐old woman, showed a high serum AFP level of 204 ng/ml. The RCC of the autopsied right kidney consisted mainly of spindle‐shaped or bizarre sarco‐matous tumor cells. AFP was immunolocalized only in the concomitant clear cell component. Concanavalin A (Con A)‐nonadsorption rate of serum AFP was 42%, which was an intermediate value between those of yolk sac tumors and metastatic liver carcinomas. Lens culinalis agglutinin (LCA)‐affinity study of the patient's AFP showed an unknown peak X, which was eluted between the known peaks 2 and 3. These results suggest a certain structural alteration in carbohydrate moieties of the AFP derived from this RCC. A review of the clincopathologic features of 8 patients with AFP‐producing RCC was made to understand the pathophysiology of AFP‐producing neoplasms. © Wiley‐Liss, Inc.
Eccrine porocarcinoma
Authors: Goedde Timothy A. , Bumpers Harvey , Fiscella Julietta , Rao Uma , Karakousis Constantine P. 
Published: February 2007

AbstractEccrine porocarcinoma, a malignancy of the eccrine sweat glands, is extremely rare. Our report and a review of the literature (70 cases) emphasize the features of this tumor. Age at time of treatment ranged from 19 to 94 years (mean 67 years). Duration of the lesion ranged from two months to 50 years; 31 (44%) had the lesion present ≥5 years. Forty‐four patients (62%) had tumors located on the extremities, 13 (19%) on the head and neck region and 12 (17%) on the trunk. All patients whose race is known were white.Primary treatment should consist of wide local excision and regional lymphadenectomy, if clinically indicated. Although there is a significant risk of cutaneous, regional lymph node, or visceral metastases, the value of elective or therapeutic regional lymphadenectomy is unknown, as is the role of adjunctive therapy. © Wiley‐Liss, Inc.
Immunohistochemical detection of CEA, CA19‐9, and DF3 in esophageal carcinoma limited to the submucosal layer
Authors: Ikeda Yoichi , Kuwano Hiroyuki , Ikebe Masahiko , Baba Kinya , Toh Yasushi , Adachi Yosuke , Sugimachi Keizo 
Published: February 2007

AbstractThe immunohistochemical expression of CEA, CA19‐9, and DF3 was studied in 20 normal epithelia, 11 cases of dysplasia, 32 squamous cell carcinomas restricted within the submucosal layer (SM carcinoma), and 42 advanced squamous cell carcinomas of the esophagus. The modes of expression were grouped into three patterns, i. e., negative, focal, and diffuse patterns. No diffuse expression of CEA, CA19‐9, or DF3 was found in the normal squamous epithelium and dysplasia. In the carcinomas (32 SM carcinomas and 42 advanced carcinomas) the diffuse expression of CEA and CA19‐9 was found in four lesions, and only one of the four lesions was an SM carcinoma, while the diffuse expression of DF3 was found in 16 of the 32 SM carcinomas and 25 of the 42 advanced carcinomas. These results indicated that the diffuse expression of these tumorassociated antigens were characteristic of tumor tissue in the esophagus, and particularly DF3 was diffusely expressed earlier than CEA or CA19‐9. The expression of DF3 in the esophagus may, therefore, be a marker of the early stage of tumor growth. © 1994 Wiley‐Liss, Inc.
Histogenesis of small colonic adenocarcinomas
Authors: Rubio Carlos , Shetye Jayant , Jaramillo Edgar 
Published: February 2007

AbstractIt has been claimed that in order to identify the type of mucosal lesion which precedes colonic adenocarcinoma only those tumours measuring ⩽1 mm in diameter should be considered. The review of the English literature indicates that only 35 colorectal adenocarcinomas measuring ⩽1 cm in diameter have been so far reported. From the three cases of colonic adenocarcinoma measuring 8 mm or less in diameter presented here, one adenocarcinoma originated in a flat adenoma, the second in an exophytic tubular adenoma, and the third showed no adenomatous component. It would thus appear that colonic adenocarcinomas can originate not only from exophytic adenomas or from flat adenomas but also from apparently nonadenomatous flat mucosa. © 1994 Wiley‐Liss, Inc.
Silver stained nucleolar organizer region proteins and Helix pomatia agglutinin immunostaining in esophageal carcinoma: Correlated prognostic factors
Authors: Yoshida Yasunori , Okamura Takeshi , Yano Kouichi , Ezaki Takahiro 
Published: February 2007

AbstractThe number of nucleolar organizer region proteins identified by silver staining (AgNORs) and alterations in cell surface glycoproteins identified by Helix pomatia agglutinin (HPA) immunostaining were studied in 96 primary esophageal carcinomas. The number of AgNORs increased with increasing depth of cancer invasion, venous involvement, lymphatic invasion, and tumor stage. Positivity of HPA staining correlated significantly with increasing depth of cancer invasion, venous invasion, and tumor stage. Forty of 42 HPA negative cases had low AgNORs numbers (<4), while 39 of 54 HPA positive cases had high AgNORs numbers (⩾4) (P = 0.0001). The survival rate of patients with stage III and IV disease was significantly poorer for those with a high AgNORs score and HPA positivity than in those with a low AgNORs score and HPA negativity. The present study indicates that the AgNORs score is positively correlated with positive HPA staining and that tumors having both factors represent a subgroup of esophageal carcinomas with poor prognosis. © 1994 Wiley‐Liss, Inc.
P53 immunoreactivity in carcinosarcoma of the esophagus
Authors: Casson Alan G. , Kerkvliet Nancy , O'Malley Frances , Inculet Richard , Troster Michael 
Published: February 2007

AbstractThe case of a primary esophageal carcinosarcoma, shown to express p53 protein, is presented. The patient, a 57‐year‐old male, presented, with fever, weight loss, and clubbing, but without swallowing difficulties. A large intraesophageal tumor was found on radiologic imaging, and sarcoma was diagnosed on esophagoscopic biopsy. Despite total esophagectomy and adjuvant chemo‐radiotherapy, pleural metastases developed 3 months postoperatively. Histologically, the tumor was composed of epithelial and sarcomatous elements. Using monoclonal and polyclonal anti‐p53 antibodies, p53 protein was distributed heterogenously throughout the sarcomatous elements of the primary tumor. Immunoreactivity was also found in regional lymph node metastases. These observations further implicate the p53 tumor suppressor gene in the pathogenesis of human esophageal cancers. © 1994 Wiley‐Liss, Inc.
Primary thymic carcinoma: A clinicopathological and immunohistochemical study
Authors: Shimizu Junzo , Hayashi Yoshinobu , Morita Katsuya , Arano Yoshihiko , Yoshida Masayuki , Oda Makoto , Murakami Shinya , Watanabe Yoh , Nonomura Akitaka 
Published: February 2007

AbstractDuring the treatment of five cases of thymic carcinoma, we conducted a clinicopathological and immunohistochemical study. The patients included four males and one female, whose ages ranged from 50 to 69 years. The histologic breakdown was squamous cell carcinoma in four and small cell carcinoma in one. Immunohistochemically, the squamous cell carcinomas were positive for cytokeratin (intermediate molecular weight) and keratin. However, staining was negative for Leu‐7 and chromogranin. A complete resection was achieved in only one case. In all four of the remaining cases, the resection was incomplete due to invasion into adjacent organs and disseminated lesions. Thymic carcinoma is a tumor for which a higher response rate can be expected from multidisciplinary therapy than that for lung cancer. Therefore, it is desirable, from the clinical view, to determine clinical staging and to establish standard operative procedures comprising mediastinal lymph node dissection as well as effective chemotherapy. With respect to pathology, it is hoped that an improved histologic classification will be developed. © 1994 Wiley‐Liss, Inc.