bluuebunny/crossref_metadata_2025_split huggingface dataset:
Shiga Toxin 2-Producing
Acinetobacter haemolyticus
Associated with a Case of Bloody Diarrhea
Authors: Grotiuz Germán , Sirok Alfredo , Gadea Pilar , Varela Gustavo , Schelotto Felipe 
Published: October 2006

ABSTRACT

We report the first Shiga toxin 2-producing
Acinetobacter haemolyticus
strain that was isolated from the feces of a 3-month-old infant with bloody diarrhea. Usual enteropathogenic bacteria were not detected. This finding suggests that any Shiga toxin-producing microorganism capable of colonizing the human gut may have the potential to cause illness.
Osteomyelitis of the Ulna Caused by
Porphyromonas gingivalis
Authors: Welkerling Heike , Geißdörfer Walter , Aigner Thomas , Forst Raimund 
Published: October 2006

ABSTRACT

A 41-year-old man was provided with a jacket crown after a root end resection of a molar. Four months later, cortical destruction of the ulnar diaphysis with swelling and pain appeared in his forearm. No microorganism could be grown from an intraoperative tissue specimen, but bacterial 16S rRNA genes were detected by broad-range PCR, revealing
Porphyromonas gingivalis
as the causative agent of osteomyelitis.
MLN120B, a Novel IκB Kinase β Inhibitor, Blocks Multiple Myeloma Cell Growth In vitro and In vivo
Authors: Hideshima Teru , Neri Paola , Tassone Pierfranchesco , Yasui Hiroshi , Ishitsuka Kenji , Raje Noopur , Chauhan Dharminder , Podar Klaus , Mitsiades Constantine , Dang Lenny , Munshi Nikhil , Richardson Paul , Schenkein David , Anderson Kenneth C. 
Published: October 2006

Abstract
Purpose: The purpose of this study is to delineate the biological significance of IκB kinase (IKK) β inhibition in multiple myeloma cells in the context of bone marrow stromal cells (BMSC) using a novel IKKβ inhibitor MLN120B.
Experimental Design: Growth-inhibitory effect of MLN120B in multiple myeloma cells in the presence of cytokines [interleukin-6 (IL-6) and insulin-like growth factor-I (IGF-1)], conventional agents (dexamethasone, melphalan, and doxorubicin), or BMSC was assessed in vitro. In vivo anti-multiple myeloma activity of MLN120B was evaluated in severe combined immunodeficient (SCID)–hu model.
Results: MLN120B inhibits both baseline and tumor necrosis factor-α–induced nuclear factor-κB activation, associated with down-regulation of IκBα and p65 nuclear factor-κB phosphorylation. MLN120B triggers 25% to 90% growth inhibition in a dose-dependent fashion in multiple myeloma cell lines and significantly augments tumor necrosis factor-α–induced cytotoxicity in MM.1S cells. MLN120B augments growth inhibition triggered by doxorubicin and melphalan in both RPMI 8226 and IL-6-dependent INA6 cell lines. Neither IL-6 nor IGF-1 overcomes the growth-inhibitory effect of MLN120B. MLN120B inhibits constitutive IL-6 secretion by BMSCs by 70% to 80% without affecting viability. Importantly, MLN120B almost completely blocks stimulation of MM.1S, U266, and INA6 cell growth, as well as IL-6 secretion from BMSCs, induced by multiple myeloma cell adherence to BMSCs. MLN120B overcomes the protective effect of BMSCs against conventional (dexamethasone) therapy.
Conclusions: Our data show that the novel IKKβ inhibitor MLN120B induces growth inhibition of multiple myeloma cells in SCID-hu mouse model. These studies provide the framework for clinical evaluation of MLN120B, alone and in combined therapies, trials of these novel agents to improve patient outcome in multiple myeloma.
A Phase I and Pharmacokinetic Study of Temsirolimus (CCI-779) Administered Intravenously Daily for 5 Days Every 2 Weeks to Patients with Advanced Cancer
Authors: Hidalgo Manuel , Buckner Jan C. , Erlichman Charles , Pollack Marilyn S. , Boni Joseph P. , Dukart Gary , Marshall Bonnie , Speicher Lisa , Moore Laurence , Rowinsky Eric K. 
Published: October 2006

Abstract
Purpose: Patients with advanced cancer received temsirolimus (Torisel, CCI-779), a novel inhibitor of mammalian target of rapamycin, i.v. once daily for 5 days every 2 weeks to determine the maximum tolerated dose, toxicity profile, pharmacokinetics, and preliminary antitumor efficacy.
Experimental Design: Doses were escalated in successive cohorts of patients using a conventional phase I clinical trial design. Samples of whole blood and plasma were collected to determine the pharmacokinetics of temsirolimus and sirolimus, its principal metabolite.
Results: Sixty-three patients were treated with temsirolimus (0.75-24 mg/m2/d). The most common drug-related toxicities were asthenia, mucositis, nausea, and cutaneous toxicity. The maximum tolerated dose was 15 mg/m2/d for patients with extensive prior treatment because, in the 19 mg/m2/d cohort, two patients had dose-limiting toxicities (one with grade 3 vomiting, diarrhea, and asthenia and one with elevated transaminases) and three patients required dose reductions. For minimally pretreated patients, in the 24 mg/m2/d cohort, one patient developed a dose-limiting toxicity of grade 3 stomatitis and two patients required dose reductions, establishing 19 mg/m2/d as the maximum acceptable dose. Immunologic studies did not show any consistent trend toward immunosuppression. Temsirolimus exposure increased with dose in a less than proportional manner. Terminal half-life was 13 to 25 hours. Sirolimus-to-temsirolimus exposure ratios were 0.6 to 1.8. A patient with non–small cell lung cancer achieved a confirmed partial response, which lasted for 12.7 months. Three patients had unconfirmed partial responses; two patients had stable disease for ≥24 weeks.
Conclusion: Temsirolimus was generally well tolerated on this intermittent schedule. Encouraging preliminary antitumor activity was observed.
Aircraft Microphysical Documentation from Cloud Base to Anvils of Hailstorm Feeder Clouds in Argentina
Authors: Rosenfeld Daniel , Woodley William L. , Krauss Terrence W. , Makitov Viktor 
Published: October 2006

Abstract
Documentation during January and February 2000 of the structure of severe convective storms in Mendoza, Argentina, with a cloud-physics jet aircraft penetrating the major feeder clouds from cloud base to the −45°C isotherm level is reported. Complementary radar, satellite, and radiosonde measurements are incorporated into the study. The main research goal was the description of the microphysical evolution of the convective feeders of the hailstorms from cloud base to the anvil in an attempt to gain insights into the microphysical evolution of the clouds that are associated with the high frequency of large hail in the region. The aircraft penetrated preferentially the tops of young growing elements, which were typically the major feeders to severe hailstorms, producing hail that is large (&gt;3 cm) in size. Cloud bases typically were at 6°–14°C, with typical base updrafts of 4–7 m s−1. The cloud updrafts increased with height, exceeding 25 m s−1 at heights ≥7 km and, on occasion, 40 m s−1 at heights &gt;8 km. Thermal buoyancies of 5°–8°C were measured in the convective towers at heights of 8–10 km. The vertical wind shear was weak below 6 km but increased strongly above that level as the west winds cleared the Andes barrier, which averages 6.1 km to the west of Mendoza. The clouds had very little coalescence and contained no detectable precipitation-sized particles &gt;100 μm at temperatures &gt;−15°C. Nearly adiabatic cloud water with most cloud water still not converted into precipitation-sized hydrometeors (&gt;100 μm in diameter) was found in cloud filaments within the strongest updrafts up to the level of homogeneous freezing, reaching 4 g m−3 at −38°C in one cloud before vanishing abruptly at colder temperatures. Graupel &gt;1 mm appeared at the tops of growing new towers at temperatures &lt;−27°C, in agreement with radar first-echo heights of about 8 km.
Retribution and Organic Unities
Authors: Clark Michael 
Published: October 2006

AbstractG.E. Moore argued that his principle of organic unities, according to which the value of a whole is to be distinguished from the value of the sum of its parts, is consistent with a retributivist view of punishment: both crime and punishment are intrinsic evils but the combination of the crime with the punishment of its perpetrator is less bad in itself than the crime unpunished. Moore’s principle excludes any form of retributivism that regards the punishment of a guilty person as an intrinsic good. Jonathan Dancy offers a different account of such unities on which, pace Moore, value does not necessarily stay the same from one context to another. This alternative account is defended, but still seems to create difficulties for various forms of retributivism.
Regulation of A Disintegrin And Metalloproteinase with ThromboSpondin Repeats-1 Expression in Human Endometrial Stromal Cells by Gonadal Steroids Involves Progestins, Androgens, and Estrogens
Authors: Wen Jiadi , Zhu Hua , Murakami Shuko , Leung Peter C. K. , MacCalman Colin D. 
Published: October 2006

Abstract
Context: Gonadal steroids are key regulators of the extracellular matrix remodeling events that occur in the human endometrium during each menstrual cycle. The spatiotemporal expression of A Disintegrin And Metalloproteinase with ThromboSpondin repeats (ADAMTS)-1 in human endometrial stroma in vivo suggests that this novel metalloproteinase may contribute to this tightly regulated developmental process.
Objective: The objective of the study was to determine whether progesterone (P4), 17β-estradiol (E2), or the nonaromatizable androgen dihydrotestosterone (DHT), alone or in combination, is capable of regulating ADAMTS-1 mRNA and protein levels in human endometrial stromal cells in a concentration- and time-dependent manner.
Design: A real-time quantitative PCR strategy and Western blotting were used to examine ADAMTS-1 mRNA and protein expression levels in primary cultures of human endometrial stromal cells.
Results: P4 and DHT but not E2 increased the levels of the ADAMTS-1 mRNA transcript and protein species (110 kDa) present in endometrial stromal cells in vitro in a concentration- and time-dependent manner. A combination of P4 and DHT resulted in an additional increase in stromal ADAMTS-1 expression, whereas E2 attenuated the regulatory effects of P4 and DHT in a concentration-dependent manner. The antisteroidal compounds, mifepristone (RU486) and hydroxyflutamide, were also found to inhibit specifically the P4- and DHT-mediated increase in ADAMTS-1 mRNA and protein expression levels in these primary cell cultures in a concentration-dependent manner, respectively.
Conclusions: These studies demonstrate that progestins, androgens, and estrogens, alone and in combination, have distinct regulatory effects on ADAMTS-1 mRNA and protein expression levels in human endometrial stromal cells in vitro.
Some effects of formaldehyde on the upper respiratory tract
Authors: Ballenger John J. 
Published: October 2006

AbstractBeing highly soluble in water gaseous formaldehyde (HCHO) is virtually completely removed by the nose during nasal respiration so that nasal disease may follow. This report is a review of pertinent information that is known about the effect of formaldehyde on the nose both in animals and humans. It is evident from the literature that rats develop nasal carcinoma at ambient levels of HCHO occasionally encountered by humans and it is hoped that this report will elucidate the possible threat HCHO presents to humans.
Solitary waves on thin falling films in the very low forcing frequency limit
Authors: Mudunuri Ramesh Raju , Balakotaiah Vemuri 
Published: October 2006

AbstractA new family of traveling waves on falling films obtained in the limit of zero pulsing frequency is presented and analyzed. A new two‐mode model that can describe the dynamics of waves for Weber numbers greater than unity is derived and validated. The speed (Ce) and peak height (hmax) relation for solitary waves is predicted to be linear by the model and its predictions are in excellent agreement with experimental data. Weakly nonlinear analysis of the new wave family, using the new two‐mode model, showed that the speed to peak height relation of these solitary waves is linear with slope $\sqrt{3}$, which is in close agreement with experimental results. Furthermore, the local bifurcation analysis shows that the relation Ce − 3 = $\sqrt{3}$(hmax − 1) is independent of the angle of the inclination as well as fluid properties and flow rate. © 2006 American Institute of Chemical Engineers AIChE J, 2006
Multiple myeloma presented as acute interstitial nephritis and rheumatoid arthritis‐like polyarthritis
Authors: Ardalan Mohammad Reza , Shoja Mohammadali Mohajel 
Published: October 2006

AbstractAcute interstitial nephritis and rheumatoid arthritis (RA) or RA‐like polyarthritis are among the very rare paraneoplastic manifestations of multiple myeloma (MM). A 47‐year‐old man with acute renal failure due to interstitial nephritis was admitted to our university hospital and successfully treated with corticosteroid. He later developed a symmetric distal polyarthritis with morning stiffness mimicking RA. On follow‐up, the patient had a rise in serum creatinine, hypercalcemia, anemia, and a monoclonal spike (Bence Jones protein) on the urine protein electrophoresis. Bone marrow biopsy demonstrated a diffuse neoplastic plasma cell infiltration. Diagnosis of MM was made and the patient received chemotherapy. After four‐course chemotherapy, the patient's articular manifestations resolved, urine monoclonal spike disappeared, and serum creatinine returned to a near normal level. We hypothesize that in this case, immunologic hypersensitivity reactions to the light‐chain molecules or other tumoral antigens deposited within the kidney or joint spaces, in the context of MM cytokine milieu may have resulted in this unusual presentation. Ultimately, clinicians and pathologists should consider MM in the differential diagnosis of the acute interstitial nephritis and RA‐like polyarthritis. Am. J. Hematol., 2006. © 2006 Wiley‐Liss, Inc.
Recurrent pancreatitis in mitochondrial cytopathy
Authors: Debray François‐Guillaume , Drouin Eric , Herzog Denise , Lortie Anne , Lambert Marie , Garel Laurent , Mitchell Grant. A. , Michaud Jacques L. 
Published: October 2006

AbstractDiabetes mellitus and exocrine insufficiency are the commonest pancreatic manifestations of mitochondrial diseases. In contrast, pancreatitis has rarely been described in mitochondrial syndromes. We report on a patient with Kearns‐Sayre syndrome and recurrent episodes of acute pancreatitis for which no explanation could be found other than the associated mitochondrial dysfunction. Interestingly, pharmacological disruption of mitochondrial metabolism in various models as well as in patients can cause pancreatitis, further supporting this association. A diagnosis of pancreatitis should be considered in any patients with mitochondrial disease and recurrent abdominal pain. © 2006 Wiley‐Liss, Inc.
Head circumference and height in autism: A study by the collaborative program of excellence in autism
Authors: Lainhart Janet E. , Bigler Erin D. , Bocian Maureen , Coon Hilary , Dinh Elena , Dawson Geraldine , Deutsch Curtis K. , Dunn Michelle , Estes Annette , Tager‐Flusberg Helen , Folstein Susan , Hepburn Susan , Hyman Susan , McMahon William , Minshew Nancy , Munson Jeff , Osann Kathy , Ozonoff Sally , Rodier Patricia , Rogers Sally , Sigman Marian , Spence M. Anne , Stodgell Christopher J. , Volkmar Fred 
Published: October 2006

AbstractData from 10 sites of the NICHD/NIDCD Collaborative Programs of Excellence in Autism were combined to study the distribution of head circumference and relationship to demographic and clinical variables. Three hundred thirty‐eight probands with autism‐spectrum disorder (ASD) including 208 probands with autism were studied along with 147 parents, 149 siblings, and typically developing controls. ASDs were diagnosed, and head circumference and clinical variables measured in a standardized manner across all sites. All subjects with autism met ADI‐R, ADOS‐G, DSM‐IV, and ICD‐10 criteria. The results show the distribution of standardized head circumference in autism is normal in shape, and the mean, variance, and rate of macrocephaly but not microcephaly are increased. Head circumference tends to be large relative to height in autism. No site, gender, age, SES, verbal, or non‐verbal IQ effects were present in the autism sample. In addition to autism itself, standardized height and average parental head circumference were the most important factors predicting head circumference in individuals with autism. Mean standardized head circumference and rates of macrocephaly were similar in probands with autism and their parents. Increased head circumference was associated with a higher (more severe) ADI‐R social algorithm score. Macrocephaly is associated with delayed onset of language. Although mean head circumference and rates of macrocephaly are increased in autism, a high degree of variability is present, underscoring the complex clinical heterogeneity of the disorder. The wide distribution of head circumference in autism has major implications for genetic, neuroimaging, and other neurobiological research. © 2006 Wiley‐Liss, Inc.
Elektrische Lichtquellen: Chemie in Lampen
Authors: Born Matthias , Jüstel Thomas 
Published: October 2006

AbstractElektrische Lichtquellen sind heute in unserem täglichen Leben in vielfältigen Anwendungen allgegenwärtig. Die Haupttriebkräfte für die Einführung neuer und verbesserter Produkte sind die stetig wachsenden Anforderungen an die Effizienz, die Lichtqualität, die Lebensdauer und die Miniaturisierung. Derzeit erobern neue Festkörperlichtquellen bestehende sowie neue Anwendungsgebiete. Der Aufsatz gibt einen Überblick über elektrische Lichtquellen und die damit verbundenen chemischen Aspekte. Ein Schwerpunkt liegt auf der Erforschung und Entwicklung der verwendeten Materialien, einschließlich Transport‐ und Korrosionsphänomenen, die der Schlüssel für Hochleistungslampen sind.
Nervenzellen mit Nanodraht verkabelt
Authors: Groß Michael 
Published: October 2006

AbstractSeit einigen Jahren ist es möglich, lebende Nervenzellen mit elektronischen Kontakten zu verbinden. Auf diese Weise könnten Mensch und Computer im Prinzip direkt kommunizieren, ohne Tastatur und Bildschirm. Doch der endgültigen Verschmelzung von Mensch und Maschine steht bisher noch der Umstand im Weg, dass die elektronischen Anschlüsse relativ grobschlächtig sind im Vergleich mit den natürlichen Verbindungen von Nervenzellen, den Synapsen.
Einblick in die Polarität und Verwendung als chirales Lösungsmittel
Authors: Feil Sylvia 
Published: October 2006

AbstractIonische Flüssigkeiten (ionic liquids, ILs) sind Salze, deren Schmelztemperaturen unter 100 °C liegen. Sie enthalten ausschließlich Ionen. Ihre besonderen Eigenschaften ergeben sich durch eine geeignete Kombination von anorganische Anionen mit organischen Kationen. In der organischen Synthese sind sie ein unkonventionelles Lösungsmittel, das in der Übergangsmetallkatalyse eingesetzt wird. Galt es bislang als chirales Lösungsmittel nicht als effizient, übertrug jetzt eine gezielt funktionalisierte IL ihre stereochemische Information auf das Reaktionsprodukt. Die Frage, wie stark Wasser mit ILs wechselwirkt, führte zu einer einfachen Methode zum Abschätzen ihrer Polarität.
Was hat Thunfisch mit Kohlenmonoxid zu tun?
Authors: Sohnius Eva‐Maria 
Published: October 2006

AbstractThunfisch in Top‐Qualität zählt zu den teuersten Lebensmitteln auf dem Weltmarkt und erfreut sich in Form von Sushi, Filets und Steaks in Europa zunehmender Beliebtheit. Gute Preise erzielen Fische mit hohem Fettgehalt und intensiv roter Farbe. Der Verbraucher verbindet die rote Farbe mit Frische.
Passivating protein coatings for implantable glucose sensors: Evaluation of protein retention
Authors: Geelhood Steven J. , Horbett Thomas A. , Ward W. Kenneth , Wood Michael D. , Quinn Matthew J. 
Published: October 2006

AbstractThe long‐term function of implantable biosensors is limited by the foreign‐body reaction (FBR). Since the acute phase of the FBR involves macrophage attachment mediated by adsorbed fibrinogen, preadsorption, and retention of other proteins might reduce the FBR. The retention of preadsorbed albumin, hemoglobin, von Willebrand's factor, and high‐molecular‐weight kininogen was therefore measured after exposure to plasma. The retention of preadsorbed proteins after incubation with monocyte cultures and implantation in rats was also measured. Fibrinogen adsorption from plasma to the preadsorbed surfaces was also measured. Hemoglobin adsorption was higher than that for other proteins, and it also had the greatest retention after exposure to blood plasma. When surfaces preadsorbed with hemoglobin were incubated with monocytes, more of the hemoglobin was displaced than that after incubation in plasma, while still more hemoglobin was displaced when the surfaces were implanted in vivo. Protein preadsorption on polystyrene greatly reduced fibrinogen adsorption. However, polyurethane surfaces used for glucose sensors had low fibrinogen adsorption compared with polystyrene, and this low level was not further reduced by preadsorption with other proteins. Preadsorbed proteins on polymers appear to be removed by passive exchange and/or displacement by plasma proteins and by proteases released by monocytes. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2006
Effects of adenovirus‐expressing IL‐10 in alleviating airway inflammation in asthma
Authors: Fu Chi‐Ling , Chuang Ya‐Hui , Chau Lee‐Young , Chiang Bor‐Luen 
Published: October 2006

AbstractBackgroundAllergic asthma strongly correlates with airway inflammation caused by cytokines secreted by allergen‐specific type‐2 T helper (Th2) cells, but the immunologic regulation of cell function is yet to be acquired. Further, IL‐10 has been found to exert both antiinflammatory and immunoregulatory activities. This study aimed to elucidate the therapeutic effects of IL‐10 administration via adenovirus‐mediated gene delivery on airway inflammation in the ovalbumin (OVA)‐induced murine model of asthma.MethodsBALB/c mice were sensitized by intraperitoneal injections with OVA and challenged by nebulized OVA. The sensitized mice were given an intratracheal delivery of adenoviral vector expressing the murine IL‐10 gene (AdIL‐10), or mock adenoviral vector 4 days before the inhalation challenge of the OVA. Inflammatory parameters, such as the development of airway hyper‐responsiveness (AHR), bronchial lavage fluid eosinophils, and chemokines were assayed.ResultsIntratracheal administration of AdIL‐10 could efficiently inhibit antigen‐induced AHR and significantly decrease the number of eosinophils and neutrophils in the bronchoalveolar lavage fluid of OVA‐sensitized and challenged mice during the effector phase.ConclusionsOur data showed that the intratracheal transfer of the IL‐10 gene could affect the recruitment of inflammatory cells during the challenge phase in a way that would result in the inhibition of airway inflammation. These findings suggest that the development of an immunoregulatory strategy based on IL‐10 might shed light on more effective treatment. Copyright © 2006 John Wiley & Sons, Ltd.