bluuebunny/crossref_metadata_2025_split huggingface dataset:
“Meaninglessness makes me unhappy”: examining the role of a sense of alienation and life satisfaction in the relationship between the presence of meaning and depression among Chinese high school seniors
Authors: Hou Xiaoxu , Hu Jinsheng , Liu Zhihong 
Published: February 2025

IntroductionGiven the high incidence of depression among adolescents and its serious consequences, investigating its influencing factors and mechanisms is of great theoretical and practical significance. This study aims to explore the mediating effects of a sense of alienation and life satisfaction on the relationship between the presence of meaning in life and depression among Chinese high school seniors.MethodsSix hundred and twenty-one senior high school students (17.09 ± 0.45 years, 266 boys) were recruited from Shandong, China, to participate in the study. Participants completed the Adolescent Students’ Sense of Alienation (ASAS), Meaning in Life Questionnaire (MLQ), Satisfaction with Life Scale (SWLS), and Beck Depression Inventory-II (BDI-II).ResultsOur findings revealed that (1) the sense of alienation and life satisfaction play a chain mediating role between the presence of meaning in life and depression among Chinese high school seniors; (2) the sense of alienation plays a mediating role between the presence of meaning in life and depression; (3) there are gender differences in the chain mediation model of the influence of the presence of meaning in life on depression.ConclusionThis study reveals potential pathways through which the presence of meaning in life affects depression among Chinese high school seniors, offering support and a basis for future mental health interventions for this population.
The influence of spousal care on the health of middle-aged and older adult caregivers in China—empirical analysis based on CHARLS data
Authors: Wang Rui 
Published: February 2025

ObjectivesWith the decrease of the number of children and the increase of population mobility, child care presents a phenomenon of “double shortage” of human and time resources, and spousal care is becoming an important care source for middle-aged and older adult people in China. However, less studies have taken middle-aged and older adult couples as research subject to explore the health effects of spousal care in the process of aging. This paper attempts to explore the effects of caregiving on the health of caregivers from the perspective of spousal care.MethodsUsing China Health and Retirement Longitudinal Study (CHARLS) database, this paper constructs a panel data fixed effect model to explore the effects of spousal care on the health of middle-aged and older adult caregivers. Further, instrumental variables (IV) estimation and propensity score matching (PSM) are used to minimize the impacts of endogeneity.ResultsSpousal care has no significant effect on the physical health of middle-aged and older adult caregivers, but it has a significant negative effect on their mental health. Providing spousal care has a stronger negative effect on the mental health of female or rural middle-aged and older adult caregivers. The mechanism analysis shows that spousal care affects the mental health by reducing the number of weekly exercise and increasing the family’s non-food expenditure.ConclusionThe provision of spousal care in the middle-aged and older adult groups does harm the mental health of caregivers. Vulnerable groups such as families in which both spouses need care, female or rural caregivers expect more attention and support.
The moderating effects of physical activity on social anxiety and sleep disturbance: managing gaming disorder in young e-sports players
Authors: Solmaz Serdar , İnan Mehmet , Şahin Mustafa Yaşar 
Published: February 2025

BackgroundInternet Gaming Disorder (IGD) has emerged as an increasing public health concern, particularly among adolescent and young e-sports players in recent years. The immersive and competitive nature of online gaming has been associated with an increase in mental health issues such as anxiety and insomnia among individuals with IGD. This study aims to examine the potential relationship between IGD, social anxiety, and insomnia, investigate the mediating role of social anxiety in this relationship, and explore the moderating role of physical activity in alleviating the negative effects of IGD.MethodsThe study involved 475 adolescent and young e-sports players aged 14–24, who typically engage in an average of 6 h of gaming per day. Participants completed the Internet Gaming Disorder Scale-Short Form, Social Anxiety Inventory, Insomnia Severity Index, and Physical Activity Frequency Question. Correlation and moderation analyses were used to examine the proposed relationships.ResultsThe findings revealed significant positive associations between IGD, social anxiety, and insomnia. Moreover, physical activity demonstrated a negative correlation with both social anxiety and insomnia. Notably, physical activity served as a moderator in the relationship between IGD and both social anxiety and insomnia, with higher levels of physical activity attenuating the adverse effects of IGD.ConclusionThis study illuminates the intricate relationship between IGD, social anxiety, and insomnia among adolescent and young e-sports players. The findings suggest that promoting physical activity may alleviate the negative psychological implications associated with IGD. These results provide important insights for the formulation of targeted intervention strategies aimed at this demographic.
Primary large cell neuroendocrine carcinoma of the urethra: a case report
Authors: Chen Jianbai , Mou Xiaorong , Zhang Zhiming , Nie Zhiyong , Qiu Jianxin 
Published: February 2025

BackgroundPrimary neuroendocrine carcinoma of the urethra is a very uncommon malignant tumor, and no reports have been made about large cell neuroendocrine carcinoma (LCNEC) in the past.Case descriptionA 43-year-old non-smoking female patient presented with symptoms of dysuria and urination-related pain at TangDu Hospital in April 2022. A biopsy subsequently confirmed the diagnosis of primary urethral LCNEC. Following radical resection, the patient exhibited abnormal lymph node enlargement in the first month and pelvic metastases in the fourth month. Ultimately, the patient succumbed to the disease 486 days after the radical resection, attributed to widespread tumor metastases and concurrent multi-organ failure. The final pathological examination confirmed the presence of a high-grade LCNEC.ConclusionThe occurrence of primary LCNEC in the urethra is exceptionally uncommon. This particular instance was notable for its aggressive progression and unfavorable prognosis. Historically, there have been no prior documented instances of primary pure LCNEC in the urethra. It is imperative to emphasize that early identification and intervention for LCNEC could potentially offer patients a more favorable survival outcome.
Breeding of Camels in Europe: Between Continuity and Innovation
Authors: Maitra Ahana , Iglesias Pastrana Carlos , Faye Bernard , Burger Pamela , Ciani Elena 
Published: February 2025

Camel breeding in Europe has undergone significant changes, intertwining historical continuity with modern innovation. Historically, dromedaries (Camelus dromedarius) and Bactrian camels (Camelus bactrianus), played essential roles in Roman logistics, medieval rituals, and agriculture, leaving archeological and cultural footprints across Europe. Following a decline during the Middle Ages, camels were largely confined to exotic collections. However, the past few decades have witnessed a resurgence in camel farming, primarily driven by tourism and the demand for camel milk, with an estimated 5000–6000 camels now present in Europe. Despite their adaptability to harsh climates and nutritional advantages, the sector faces challenges such as small population sizes, fragmented breeding efforts, and the absence of regulatory frameworks tailored to camels. Advances in genomic tools, including genome-wide association studies and SNP genotyping, have created opportunities for the genetic management of camels in Europe, yet also reveal concerns about low genetic diversity stemming from founder effects. Addressing these issues requires coordinated international efforts, standardized phenotype recording, and enhanced welfare guidelines. With climate change highlighting the resilience of camels to arid environments, their potential as sustainable livestock remains promising. This review underscores the balance between preserving the historical legacy of camels in Europe and fostering their integration into contemporary agricultural systems.
Exploring the Therapeutic Potential of Extracellular Vesicles Anchored to the Sea Cucumber Extracellular Matrix for Treating Atopic Dermatitis
Authors: Jo Sung-Han , Kim Seon-Hwa , Heo Su Chin , Cho Hongsik , Esfahani Iman Janghorban , Park Sang-Hyug 
Published: February 2025

Extracellular vesicles (EVs) are crucial for intercellular communication and affect various physiological and pathological processes. Although terrestrial EVs have been extensively studied, marine-derived EVs have yet to be explored. This study investigated the therapeutic potential of sea cucumbers, known for their regenerative and immune abilities. Sea cucumber extracellular matrix (ECM)-anchored EVs (SEVs) were isolated and characterized using physical and electrophoretic analyses. Morphological assessments have shown that SEVs have shape and size distributions similar to mammalian EVs. Internal cargo analysis revealed the encapsulation of diverse proteins and genetic molecules. In anti-inflammatory tests with a lipopolysaccharide (LPS)-induced macrophage model, the results have shown that SEVs can alleviate inflammation factors regarding inducible nitric oxide synthase (iNOS) protein and immune-related mRNA expression. Microarray analysis was conducted to elucidate SEV’s pharmacological efficacy and anti-inflammatory mechanisms, showing that SEVs inhibit the nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) signaling pathway. An in vivo study using a mouse model of atopic dermatitis (AD) induced by 2,4-dinitrochlorobenzene (DNCB) involved subcutaneous SEV administration, followed by severity scoring and histological analyses. Therapeutic efficacy analysis indicated improvements in the AD mouse models, including reduced skin thickness and mast cell numbers. These findings indicate their potential for treating AD. This study highlights the potential clinical applications of marine-derived EVs and offers important implications for future research and therapeutic developments.
Peran Guru dalam Inovasi Pendidikan Anak Usia Dini Membangun Masa Depan Berkualitas
Authors: Hidupi Dasa Wisra , Zohro Nailul Padhil , Akip Muhamad 
Published: February 2025

Inovasi dalam pendidikan melibatkan konsep-konsep seperti perubahan, pembaharuan, dan cara kerja baru untuk mencapai tujuan yang telah ditetapkan. Tujuan penelitian ini adalah peran guru dalam menciptakan inovasi pendidikan anak usia dini dapat berkontribusi dalam membangun masa depan yang berkualitas bagi generasi yang akan datang. Penelitian ini menggunakan pendekatan penelitian kualitatif dengan studi pustaka. Hasil penelitian menunjukkan bahwa peran guru dalam menerapkan inovasi pendidikan untuk meningkatkan kualitas pendidikan sangat ditekankan. Guru tidak hanya sebagai pengajar, tetapi juga sebagai fasilitator, penggerak transformasi, dan elemen kunci dalam menciptakan lingkungan pembelajaran yang inovatif dan berkualitas. Guru berkontribusi dalam menghadirkan inovasi dalam proses pembelajaran melalui pemilihan model pembelajaran yang sesuai, yang memengaruhi pencapaian hasil belajar siswa. Guru memiliki tanggung jawab dalam menghadirkan inovasi dalam pendidikan inklusif, mengurangi penggunaan layar pada anak usia dini, dan menggalakkan aktivitas fisik dalam pendidikan. Peran guru dalam menerapkan inovasi pendidikan sebagai fasilitator, katalisator perubahan, dan penggerak transformasi menunjukkan betapa vitalnya peran guru dalam menciptakan lingkungan pembelajaran yang inovatif dalam masyarakat melalui inovasi pendidikan. Guru memiliki peran dalam meningkatkan kualitas pendidikan dengan memperhatikan kebutuhan dan kepentingan siswa.
Examining the nutritional habits of individuals with moderate and severe covid-19, evaluation of changing nutritional habits and physical activity behavior after covid-19
Authors: ÇAĞLAYAN NİLAY , Nacar Erkay 
Published: February 2025

Objective: This research aimed to examine the eating habits of adult individuals infected with severe and moderate COVID-19 disease and to evaluate the changing eating habits and physical activity behaviors of post-COVID-19 individuals.
Methods: The cross-sectional study included 1340 people over the age of 18 and had a positive PCR test. The data was collected online with the ”Google Form". The obtained data were analyzed with the statistical package program SPSS 25 (Statistical Package for Social Science). Data Mean±Standard Deviation and percentage distribution and the Chi-square test were used in its analysis. p<0.05 significance level was considered statistically significant.
Results: It was found that the food consumption of 66.7% of the participants and the number of meals of 82.2% did not change after infection. It has been concluded that individuals do not pay attention to healthy nutrition after infection.It was found that 71.1% of the individuals didn’t do regular physical activity and this situation didn’t change after COVID-19.
Conclusion: In line with the results obtained from the study, it is necessary to pay attention to the nutritional habits and physical activity status of individuals. Nutrition education should be provided by dietitians, accurate information should be provided by physical therapists to increase physical activity.
Рецензия на монографию О. М. Валовой, В. Г. Решетова «Философия трагедий Оскара Уайльда» (Киров : Вятск. гос. ун-т, 2023. 342 с.)
Authors: Доценко Е.Г. 
Published: February 2025

Рецензируемая монография доктора филологических наук, профессора Вятского государственного гуманитарного университета Ольги Михайловны Валовой и доктора филологических наук, профессора Рязанского государственного университета имени С. А. Есенина Владимира Григорьевича Решетова посвящена изучению конкретного аспекта творчества О. Уайльда: жанровой и стилевой специфике трагедий британского классика. Доминантой исследования стала философская составляющая творчества писателя, а также философская база его эстетизма, поэтому, подробно и последовательно анализируя пьесы, авторы монографии не ограничиваются рассмотрением только драматического наследия Уайльда, представив в своей работе новый целостный портрет крупнейшего деятеля английского декаданса. Монография вышла в свет в преддверии 170-летнего юбилея Оскара Уайльда.
The peer-reviewed monograph by Olga Mikhaylovna Valova, doctor of philology, professor of Vyatka State University for the Humanities, and Vladimir Grigoryevich Reshetov, Doctor of Philology, Professor of Ryazan State University named for S. A. Yesenin, is devoted to the study of a specific aspect of O. Wilde’s work: the genre and style specificity of the British playwright’s tragedies. The dominant feature of the study is the philosophical component of the writer’s work, as well as the philosophical basis of his aestheticism, so, analyzing the plays in detail and consistently, the authors of the monograph do not limit themselves to the consideration of Wilde’s dramatic heritage alone, presenting in their work a new holistic portrait of this major figure of the English decadence. The monograph was published on the eve of Oscar Wilde’s 170thanniversary.
Modeling the Saddle-like GeV–TeV Spectrum of HESS J1809–193: Gamma Rays Arising from Reverse-shocked Pulsar Wind Nebula?
Authors: Sun Jiaxu , Chen Yang , Bao Yiwei , Zhang Xiao , Zhou Xin 
Published: February 2025

Abstract
The evolution of pulsar wind nebulae (PWNe) could be expected to leave imprints in gamma rays. We suggest that the intriguing GeV–TeV spectral energy distribution (SED) of HESS J1809–193 and Fermi-LAT source J1810.3–1925e is very likely to be the gamma-ray signature of PWN J1809–193 in light of the scenario that the PWN was struck by the reverse shock of the parent supernova remnant. Based on the evolutionary theory of PWNe, we consider that, when the PWN was disrupted during a collision by the reverse shock, some VHE electrons escaped impulsively. The remaining electrons stayed in the relic PWN, which was displaced from the pulsar. The VHE part of the remaining electrons was depleted by the strong magnetic field that was enhanced by the reverse shock compression in the reverberation stage, leaving the other part of them generating GeV emission. The particles injected from the pulsar after the disruption enter the relic PWN through the newly formed tunnel called the cocoon. The gamma-ray emission from the escaped electrons can account for the TeV spectrum of component A of HESS J1809–193 or the TeV halo, while the electrons remaining after disruption can account for the GeV spectrum of J1810.3–1925e. Thus, the combination of contributions from these two populations of electrons naturally reproduces the saddle-like SED of HESS 1809–193 and J1810.3–1925e from 5 GeV to 30 TeV, together with the spectral hardening around 100 GeV. We also show that the post-disruption injection of electrons can explain the spectrum of the relatively faint gamma-ray emission of component B of HESS J1809–193.
Thermally Driven Atmospheric Escape: Transition from Diffusion-limited to Drag-off Escape
Authors: Evans Jack C. , Carberry Mogan Shane Robert , Johnson Robert E. , Tucker Orenthal J. 
Published: February 2025

Abstract
We examine the transition from diffusion-limited to drag-off escape using a direct simulation Monte Carlo (DSMC) model developed to simulate planetary atmospheres, referred to as Harrah. A 1D spherically symmetric DSMC model is used to simulate two-component atmospheres to focus on the impact of rarefaction on thermal diffusion. The results for the escape rates and thermal structure are characterized using a mass-averaged Jeans parameter, λ
avg,0, and Knudsen number, Kna,0, defined at a reference radial distance r
0. As a test of the model, we simulated the escape of N2 and H2 self-consistently for conditions of Pluto’s upper atmosphere observed during the New Horizons mission. As expected, the DSMC result for H2 escape is consistent with the diffusion-limited approximation, and H2 escape has little effect on the background N2 atmosphere. Then we examined the transition from diffusion-limited to drag-off escape for two-component atmospheres characterized by mass-averaged Knudsen numbers and Jeans parameters of Kna,0 ≈ 0.01–0.1 and λ
avg,0 ≈ 0.5–13, respectively. We found that escape transitioned from hydrodynamic escape to an enhanced Jeans-like escape at λ
avg,0 ≈ 3.0–3.6. For values of λ
avg,0 < 3.0–3.6, escape was hydrodynamic and in the blow-off regime. For values of λ
avg,0 >≈ 3.6, the DSMC results indicated that using the diffusion-limited and drag-off approximations can lead to inaccurate estimates of the escape rate.
Screening for Pathogens and Studying Bats’ Blood and Tissue Microbiome
Authors: Panaiotov Stefan , Tsafarova Borislava , Hodzhev Yordan , Nenova Rumyana , Mikov Ognyan , Tolchkov Vladimir , Dimitrova Aleksandra , Slavov Gancho , Nedyalkov Nedyalko , Langourov Mario , Bekchiev Rostislav , Stoev Pavel , Simov Nikolay 
Published: February 2025

Bats possess unique physiological adaptations, including thermophysiological flexibility, which enable them to tolerate and harbor diverse pathogens without overt disease. Their ability to sustain powered flight and enter torpor or hibernation contributes to their immune resilience, making them important reservoirs for zoonotic pathogens such as viruses (rabies, Ebola, coronaviruses) and bacteria (Leptospira, Salmonella, Bartonella, Rickettsia). Bats' dense social roosting and migratory behaviors facilitate pathogen transmission, underscoring the need for effective surveillance.
This study examined the blood microbiomes of five bat species from the Vespertilionidae and Rhinolophidae families inhabiting three caves in northern Bulgaria (Devetashka, Orlova, and Parnicite). Using pooled blood samples (n=120) and two bat hearts, DNA was extracted for microbiome analysis via shotgun metagenomic sequencing, alongside PCR-based detection of human pathogens.
Bacterial phyla and genera distribution varied significantly among bat species, with prominent genera including Bacillus, Mycoplasma, Pseudomonas, and Sphingobacterium. Alpha diversity, measured by the Simpson index, revealed slightly higher microbial diversity in Miniopterus schreibersii and Myotis myotis, with no significant differences among cave populations. Principal Coordinates Analysis (PCoA) highlighted distinct microbial community compositions between bat species and cave locations. PCR results identified Mycobacterium in 26 of 34 blood samples and in 1 of 2 heart tissue samples, suggesting its prevalence in bat populations. No samples tested positive for Mycobacterium tuberculosis, Brucella spp., Coxiella burnetii, or Toxoplasma gondii, indicating the absence of these pathogens in the sampled individuals. The detection of atypical Mycobacteria and Brucella sp. in the bats' blood emphasizes its potential role as an opportunistic pathogen and the need for further investigation into its zoonotic significance. These findings highlight the diversity and zoonotic potential of bat-associated microbiomes, supporting the need for continued pathogen surveillance in bat populations. All metagenomic shotgun sequencing data were published at NCBI Sequence Read Archive under the bioproject number PRJNA1215671.
Choix des études et abandon scolaire précoce dans l’enseignement secondaire espagnol
Authors: Jiménez Ramírez Magdalena , González Faraco Juan Carlos 
Published: February 2025

Les données montrent régulièrement que les taux espagnols d’abandon scolaire précoce et de chômage des jeunes restent, malgré des améliorations récentes, les plus élevés d’Europe. Une part importante de ce problème trouve son origine dans l’enseignement secondaire et, en particulier, dans ses transitions. Cet article analyse cette situation et ses conséquences sur les trajectoires de vie des étudiants. Il étudie également les actions que l’on souhaite mettre en œuvre pour atténuer ces problèmes, notamment : la promotion de la formation professionnelle duale, la diversification et la flexibilisation des itinéraires de formation, et le développement de l’orientation scolaire et familiale, en ce qui concerne le choix des études pendant et à la fin de l’enseignement secondaire obligatoire.
Un regard sur les facteurs qui influencent les choix éducatifs des adolescents en Uruguay
Authors: Viscardi Etchart Nilia 
Published: February 2025

En Uruguay, à la fin de la quatrième année de l’enseignement secondaire, les élèves doivent définir leur parcours scolaire ultérieur en choisissant des options spécifiques. L’article s’intéresse aux facteurs qui influencent les choix éducatifs des adolescents et le contexte de leurs parcours éducatifs au moment où ce choix doit être fait, c’est-à-dire à l’âge de 15 ans. L’analyse porte sur l’orientation professionnelle proposée dans le cadre des programmes éducatifs ; le rôle des acteurs pédagogiques et des psychologues dans les lycées ; le poids de la famille. Si, ces dernières années, un plus grand nombre de jeunes issus de familles à faibles revenus parviennent à réussir dans le système éducatif, des inégalités persistent et se reproduisent au niveau de l’enseignement secondaire au moment du choix de formation.