bluuebunny/crossref_metadata_2025_split huggingface dataset:
QR-code Cards for Residents: A Novel Method for Post-ED Visit Follow-up and Reducing Burnout
Authors: Peng Paul , Simmons Cailey , Villars Melissa , Rabin Elaine 
Published: April 2024

Abstract

Objective:
There is no formal expectation for emergency medicine (EM) residents to follow up on a particular patient after discharge, and it is unknown how residents perceive further contact outside of an Emergency Department (ED) visit. We hypothesize that standardized, dynamic-QR-code embedded cards (“Follow-up Cards”) handed out by residents to patients would provide a means to communicate and follow-up. For select patient encounters, we further hypothesize that residents may derive greater personal accomplishment and meaning from their clinical duties after this intervention.
Methods:
This was a prospective cohort observational study of 86 residents surveyed on perceptions of follow-up outside of the ED visit as well as the baseline level of burnout using the Copenhagen Burnout Inventory (CBI). Four months after the intervention of “Follow-up Cards”, we reassessed the CBI, quantified the utility of cards via QR code statistics, and surveyed residents’ feedback.
Results:
There was a 92% response rate to the pre-intervention survey and high internal consistency (𝛼 coefficient = 0.70—0.79) for the 3 domains of the CBI. In terms of perceptions of follow-up, 58.2% deemed it moderately important, 41.8% felt positive about patient communication after an ED visit, and most residents valued learning about the eventual clinical course. Card distribution per resident ranged from 0 to 11 over 4 months. Among interns, patient-related burnout was almost significantly lower after the intervention (27.1 vs 39.3, p = 0.06). “Follow-up Cards” were uniquely scanned by patients 147 times over the 4 months. The primary barriers cited against follow-up were lack of time and increased workload (combined, 75.8%).
Conclusions:
“Follow-up Cards” were demonstrated in this study as a proof-of-concept and feasible means of patient-physician contact after an ED visit. While follow-up communication was found to be relatively rare overall, there is potential for enriching certain patient encounters.
Facilitating Comprehensive Child Health Monitoring with Real-Time Z-Score assessments using REDCap
Authors: Mendon Priyanka , Witsch Michael , Becker Marianne , Adamski Aurélie , Vaillant Michel 
Published: April 2024

Abstract

Background
Monitoring of somatic development through the assessment of anthropometric variables such as weight, height and BMI is vital for evaluating the physical development and nutritional status of children. This approach aids in the early identification of somatic developmental disorders, enabling timely medical interventions. It traditionally relies on Z-scores, which compare anthropometric variables to reference standards. In addition to somatic development monitoring, the early detection and management of pediatric and adolescent hypertension are crucial due to potential long-term health risks. However, manual calculations of Z-Scores are time-consuming and error-prone, impeding timely interventions for at-risk children. This study introduces an innovative open code solution for real-time Z-score assessments directly within the electronic data capture platform, REDCap ™ (Research Electronic Data Capture), aiming to streamline the monitoring of somatic development in children.
Methods
Leveraging the WHO (World Health Organization) growth standards and NHANES (National Health and Nutrition Examination Survey) references, our approach integrates Z-score computations directly into REDCap, providing a secure and user-friendly environment for healthcare professionals and researchers. The study employs Bland-Altman analyses to compare our method with established calculators (Knirps and Growth XP ™).
Results
Bland-Altman plots demonstrated a strong agreement between our REDCap calculations and the Knirps and Growth XP systems. Z-scores for height, weight, and BMI consistently aligned, affirming the accuracy of our approach across the measurement range.
Conclusion
The integration with REDCap streamlines data collection and analysis, eliminating the need for separate software and data exports. Moreover, our solution uses the World Health Organization (WHO) growth standards and National Health and Nutrition Examination Survey (NHANES) references. This not only ensures calculation accuracy but also enhances its suitability for diverse research contexts. The Bland-Altman analyses establish the reliability of our method, contributing to a more effective approach to child growth and blood pressure monitoring.
Trial Registration:
Not applicable since, this paper is an open code solution for real-time Z-score assessments directly within REDCap. However, the motivation to develop an open code stemmed from a project titled "Screening for Familial Hypercholesterolemia in Primary School Children: Protocol for a Cross-Sectional, Feasibility Study in Luxembourg City (EARLIE)." (Trial registration number NCT05271305)
Efficacy of Quercetin on rat eyelid wound healing, a randomized, sham-controlled double-blind study
Authors: iritaş seçil yigen , iritaş ilter , sarıtaş zülfükar kadir , görücü Fatma , demirel hasan hüseyin , bülbül Aziz , koç yusuf 
Published: April 2024

Abstract

Introduction:
Although quercetin has been found to be useful in the treatment of pressure wounds due to its ability to reduce oxygen radicals, its effect on healing wounds on the eyelids is not clear.
Objective
To investigate the effect of quercetin on eyelid wound healing.
Method and Materials:
Forty male Wistar Albino Rats weighing 250–300 grams were used. Four groups were created. Control Group (n = 10), Sham Group (n = 10), Incision Wound Group (n = 10), and Suture + Quercetin Group (n = 10). Full-thickness skin excision was performed through a 3–5 mm incision in the superior palpebrae to create a wound. On the 3rd day and (n = 5) on the 7th day, they were sacrificed, and blood samples were taken by cardiac puncture for biochemical measurement and tissue samples for histopathological examination from the palpebrae.
Results
Inflammatory cells in the Quercetin Group were significantly lower in 3. Day (p < 0.05). Blood levels of IL-1 and TNF-alfa were significantly lower in the Quercetin Group (p < 0.05) when compared with other groups. The Quercetin Group is as influential as the sham group at 3. Day for collagen formation and hydroxyproline value is significantly higher. Total oxidant status levels were lower in the Quercetin group than in the Sham group (p = 0.005).
Conclusions
Quercetin was found to be anti-inflammatory and antioxidant, and these properties can lead to decrease in wound healing time. Also, Quercetin healed wounds and scavenged free radicals effectively.
Silica/APTPOSS anchored on MnFe 2 O 4 as an efficient nanomagnetic composite for the preparation of spiro- pyrano[2, 3-c]chromene derivatives
Authors: Najafabadi Samira Moein , Safaei-Ghomi Javad 
Published: April 2024

Abstract
The synthesis of Octakis [3- (3-amino propyl triethoxysilane) propyl] octa-silsesquioxane (APTPOSS), a derivative of polyhedral oligomeric silsesquioxane, was utilized to produce an efficient nanocomposite. MNPs@Silica/APTPOSS was characterized through scanning electron microscopy, Fourier transform infrared spectroscopy, vibrating sample magnetometry, X-ray diffraction, and thermogravimetric analysis. These magnetic nanoparticles, a combination of organic-inorganic hybrid polyhedral oligomeric silsesquioxane, were utilized as a proficient heterogeneous catalyst in the one-pot synthesis of spirooxindoles derivatives. Furthermore, they could be swiftly isolated and reused six times while maintaining their catalytic efficiency.
D-mannose alleviates chronic periodontitis in rats by regulating the functions of neutrophils
Authors: Li Xue , Chen Xueting , Zhu Qingyu , Zhang Pengye , Nan Shunxue , Lv Lei , Qi Shengcai 
Published: April 2024

Abstract

Background
Periodontitis is a chronic inflammatory disease without effective treatment. Nowadays, the critical role of neutrophils in periodontitis is getting better and better understood. The study aimed to explore the protective effects of D-mannose on chronic periodontitis and determine whether its underlying mechanisms is related to neutrophils.
Methods
To explore the protective effects of D-mannose on chronic periodontitis, the rat model of lipopolysaccharide (LPS)-induced periodontitis was established, followed by D-mannose treatment by oral gavage. To evaluate the protective effects of D-mannose against periodontal bone loss, methylene blue staining, hematoxylin and eosin (H&E) staining, and micro-CT scanning were utilized. Then, immunofluorescence (IF), Western Blot, and RT-PCR were applied to assess the expression levels of pro-inflammatory cytokines (IL-1β, IL-6, and IL-17), anti-inflammatory cytokine (IL-10), tumor necrosis factor-alpha (TNF-α), granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF), ten-eleven translocation 2 (TET2), and key glycolytic enzymes (HK1, HK2, PFKFB3), and to examine D-mannose's impact on the recruitment and activation of neutrophils in the gingiva. Additionally, neutrophils isolated from the peripheral blood of healthy rats were treated with LPS and D-mannose, and changes in the expression levels of myeloperoxidase (MPO), IL-1β, IL-6, IL-17, IL-10, and TET2 were observed via IF.
Results
In vivo, D-mannose inhibited LPS-induced alveolar bone resorption in rats and suppressed the expression levels of IL-1β, IL-6, IL-17, TNF-α, G-CSF, GM-CSF, TET2, HK1, HK2, and PFKFB3, upregulated the expression level of IL-10, and inhibited the recruitment and activation of neutrophils in LPS-treated rat gingival tissues. In vitro, D-mannose was found to inhibit the activation of neutrophils stimulated by LPS, downregulate the expression of IL-1β, IL-6, IL-17, and TET2, and upregulate the expression of IL-10.
Conclusions
D-mannose can alleviate chronic periodontitis in rats by regulating the functions of neutrophils, potentially associated with the expression of TET2 and glycolysis, providing new insights into the potential application of D-mannose to chronic periodontitis.
Effectiveness of video monitoring in transition of care for patients with heart failure (EVIT-HF): a study protocol for a randomized clinical trial
Authors: Neto Omar Pereira de Almeida , Jhund Pardeep S. , Rabelo-Silva Eneida Rejane , Magnabosco Patrícia , Marchiori Gianna Fiori , Araújo Izadora Vieira , Alcântara Maria Eduarda de Pádua 
Published: April 2024

Abstract
Background
Real data on the impact on prognosis of video monitoring in patients with heart failure (HF) are limited and inconclusive. This article aim to describe a randomized clinical trial protocol designed to assess the efficacy of a video monitoring and educational strategy delivered to patients with heart failure with reduced ejection fraction (HFrEF).
Methods
This is a randomized, parallel trial with blinded outcome assessment. During hospitalization patients who meet the inclusion criteria will be invited to participate. Sociodemographic data, clinical variables, results of laboratory tests, current medications and cardiovascular physical examination will be collected. Additionally, Clinical congestion score, European HF self-care, HF knowledge, HF treatment adherence, HF quality of life and cardiorespiratory fitness will be collected by specific, validated instruments. The control group (CG) will receive the usual care after hospital discharge. In the intervention group (IG), the clinical discharge summary will be shared with the nurse of the primary health care unit in order to discuss the transition care. IG participants will receive specialized cardiovascular nursing appointments through video monitoring (at 7 days, 30 days, 60 days, and 180 days). The primary outcome consists of the self-care score. Secondary outcomes will be quality of life scores, HF knowledge scores, HF treatment adherence scores and cardiorespiratory fitness scores, death rates and hospital readmissions.
Discussion
Unlike strategies based on mobile devices or voice telemonitoring, the video monitoring, hypothetically is a strategy able to generate greater bond and trust between patients and health professionals, leading to improvements in the outcomes measured.
Trial registration: https://ensaiosclinicos.gov.br/rg/RBR-9fkncwv
Impact of Comorbidity on Mortality in COVID-19 Patients: A Single- Center Retrospective Study
Authors: Al-aghbari Nuha , Maldar Arif , Angolkar Mubashir , Khurseed Romana 
Published: April 2024

Abstract

The global spread of COVID-19 has had a profound impact on human health, with millions of people infected and a significant death. Comorbidities play a pivotal role in the prognosis of COVID-19 patients. The aim of this study was to assess the impact of the comorbidity on mortality in COVID-19 patients in a Single-Centre Retrospective Study. The characteristics and results of patients with COVID-19 admitted to KLE's Hospital in Belgaum, Karnataka, India, were examined through retrospective research. 642 participants having COVID-19 diagnoses between October 1, 2020, and September 30, 2021 were enrolled in the research. Data such as, patients' clinical features, vital signs, demographic information and patients' outcomes (survived or deceased) were collected. The findings of this study showed that out of 642 patients, 256 patients had co morbidities, 62.8% of them had poly morbidity and most prevalent underlying medical conditions were hypertension, diabetes, and heart disease which affected 30.7%, 29.1, and 7.9%, respectively. Only diabetes and renal disease reported strong associations (P.value: 0.011, aOR: 1.852 95% CI: 1.148–2.988), (p.value: 0.000, aOR: 6.491 (95% CI: 2.613–16.124), respectively. Furthermore, Comorbidities such kidney disease, and diabetes mellitus can lead to more serious complications and death in COVID-19 patients. Understanding the impact of these comorbidities on COVID-19 mortality is essential for more effective patient care and resource allocation.
Stabilization using the separation principle for generalized classes of fractional-order fuzzy systems
Authors: Ahmed Hassen , Jmal Assaad , Makhlouf Abdellatif Ben 
Published: April 2024

Abstract

The separation principle has been extensively used in the literature to tackle the observer-based control problem for integer-order linear and Lipschitz nonlinear systems. However, less interest has been given by researchers to treat the same problem, in the fractional-order framework. In this context, this paper introduces and investigates a separation principle tailored for two advantageous classes of nonlinear fractional-order fuzzy systems. These two classes can be regarded as generalizations of the classical nonlinear Lipshchitz systems. The research explores both asymptotic stability and practical Mittag-Leer stability, unveiling a novel approach to handling intricate fractional-order systems with fuzzy characteristics. Through rigorous theoretical analysis and simulation studies, the paper demonstrates the ecacy and applicability of the separation principle, for both considered classes of fractional fuzzy systems.
Patriarchy and Child Well-Being: Evidence from India
Authors: Islam T M Tonmoy , Kearns Morgan , Mitra Shabana 
Published: April 2024

Abstract

The nutrition and care received in childhood can have a profound impact on the adult life of an individual. Governments and the United Nations have emphasized proper care and nutrition for children, and the Sustainable Development Goals have targeted the elimination of stunting and wasting of children under the age of 5 by 2030. However, South Asia is lagging behind in this metric; the World Bank has noted that about 32 percent of Indian children under age of 5 is stunted, while the world average is 22 percent. While a number of studies have looked into ways of improving well-being of a child, and women’s empowerment, the relationship between patriarchy and children well-being has not been extensively studied. In this paper, we use data from the 2019 Demographic and Health Survey of India to study this relationship. We modify the patriarchy index outlined in Singh et al (2022) and use it in our paper. Our primary dependent variable is the standardized height-for-age percentile. We find that patriarchy negatively affects child height in the northern parts of India, and among certain religious groups. We theorize that culture of the land together with religion of the household impacts how patriarchy affects child height.
Flavopiridol induces cell cycle arrest and apoptosis by interfering with CDK1 signaling pathway and inducing excessive reactive oxygen species in human ovarian granulosa cells
Authors: Li Xiao-Zhen , Yang Li-Jia , Song Wei , Xie Xue-Feng , Jiang Jia-Xin , Zhang Xue , Zhou Chang-Yin , Li Ang , Li Fei , Yin Shen , Sun Qing-Yuan 
Published: April 2024

Abstract
In recent years, several clinical trials have been conducted to evaluate the use of flavopiridol to treat a variety of cancers, however, it is not clear whether the use of this drug will affect the female reproductive system. Granulosa cells, one of the important cells that constitute the follicle, play a crucial role in determining the reproductive ability of females. In this study, we observed whether different concentrations of flavopiridol have a toxic effect on the growth of immortalized human ovarian granulosa cells. We showed that flavopiridol had an inhibitory effect on cell proliferation at a level of nanomole concentration. Flavopiridol reduced cell proliferation and induced apoptosis by inducing mitochondrial dysfunction and oxidative stress, as well as increasing BAX/BCL2 and pCDK1 levels. These results suggest that reproductive toxicity should be considered when flavopiridol is used to the clinical work.
Three-dimensional sand particle shape characterization by PointConv-Transformer deep learning
Authors: Xi Junbo , Zheng Junxing , Gao Lin , Wang Dong , Jiang Jin , Chen Shu 
Published: April 2024

Abstract

Angularity and sphericity of sand particles significantly influence the shear strength, compressibility, void structure, and deformation behavior of soils. However, current computational geometry (CG) algorithms face challenges in simultaneously charactering angularity and sphericity, as well as handling defective granular three-dimensional(3D) mesh. To address these efficiency and robustness limitations, this paper introduces the PointConv-Transformer deep learning algorithm for characterization and classification of sand particles point cloud. The PointConv efficiently captures local features of angularity and sphericity. Subsequently, the Transformer integrates these local features into global features to form the judgement basis for classification. The 4800 particle point clouds are labeled with 12 angularity-sphericity classes. The PointConv-Transformer model, trained on the produced dataset, achieves an automatic classification accuracy of 96.65%. Furthermore, we explore the impact of normal vectors and point cloud size on the performance of the PointConv-Transformer model. Experimental results demonstrate that the optimal performance of the trained model is achieved when the point cloud size is 2000 and includes normal vectors. Finally, compared to traditional 3D CG, the classification results align closely in volume, surface area, and convex hull volume metrics. As the number of classified particles increases, the advantage in classification efficiency becomes more pronounced.
Report on roadkill of Particolored flying squirrel (Hylopetes alboniger) (Hodgson, 1836) from Kaziranga, Assam
Authors: Gupta Sourav , Begum Ramie H. , Ahmed M. Firoz , Roy Jayanta Kumar 
Published: April 2024

Abstract
Notably, flying squirrels, essential yet understudied components of ecosystems, face heightened risks due to their cryptic habits. We report the first documented roadkill case of a particolored flying squirrel (Hylopetes alboniger) in Assam, India, highlighting the need for comprehensive roadkill surveys to inform mitigation strategies in biodiverse regions facing increasing anthropogenic pressures.
Geotechnical performance of XCC pile under torsion loads in clay soil – Numerical study
Authors: Azzam Waseim Ragab , Nasr Ahmed Mohamed , Abdallah Samir Sabry 
Published: April 2024

Abstract

A series of three–dimensional finite – element models (PLAXIS 3D V20) were developed to investigate the non-linear behavior of XCC section piles under torsional load in clay soil with various soil cohesion states. Piles were assumed to behave in a linear elastic model, while the soil was modeled using the non-linear (HSM) hardening soil model. The influence of pile length to pile diameter ratio (Lp/Dp), 0pen arc spacing to pile diameter ratio (ap/Dp), and open arc degrees(θ˚) were explored. the numerical results showed that the torsional capacity of the pile increases with the increase of clay cohesion. At the ratio of pile length to pile diameter (Lp/Dp) = 15, and the ratio of the open arc spacing to pile diameter (ap/Dp) = 0.14, open arc degrees(θ˚) = 90 the efficiency of improvement in the torsional capacity reached to 3.96, 5.06, and 5.71 times of torsional capacity of conventional pile with the same cross-sectional area at clay cohesions of 70 KN/m2, 40 KN/m2, and 30 KN/m2, respectively. furthermore, the torsional capacity of the XCC section pile increases with the increase in soil cohesion (Cu), pile diameter (Dp), pile length (Lp), and open arc spacing. but it decreases with the increase of open arc degrees(θ˚). The change of shape to XCC shape can significantly increase the earth pressure and skin friction around the pile by creating a passive zone, and increasing the perimeter.
The numerical investigation of groove parameters in a bionic vapor chamber
Authors: Zhu Shuiping , Li Yong 
Published: April 2024

Abstract

As high heat flux density electronic devices become more miniaturized, lightweight, and highly integrated, the thermal management of these devices faces significant challenges. This paper proposes a bionic vapor chamber (B-VC) with a secondary groove structure to further enhance its heat transfer. Numerical simulation results demonstrate that the B-VC with the secondary groove structure can achieve better heat transfer performance than one without the secondary groove, as the secondary groove provides a larger heat transfer area. The heat transfer performance enhancement increases with an increase in the width of the secondary groove. However, the B-VC with the secondary groove incurs a higher pressure drop penalty. The effects of groove parameters, including the groove branch level and groove trunk width, on the overall performance were also investigated within the B-VC framework. The heat transfer performance enhancement increases with an increase in the groove branch level and groove trunk width. Based on a figure of merit (FOM) calculation, it is recommended that the groove branch level should be no more than two. Furthermore, the optimum groove trunk width was found to be 2 mm, which corresponds to a ratio of the gas-liquid channel cross-sectional areas of 14.3%.