bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pancreas-preserving total duodenectomy versus standard pancreatoduodenectomy for patients with familial adenomatous polyposis and polyps in the duodenum
Authors: de Castro S M M , van Eijck C H J , Rutten J P , Dejong C H , van Goor H , Busch O R C , Gouma D J 
Published: October 2008

Abstract

Background
Pancreas-preserving total duodenectomy (PPTD) was introduced as a replacement for pancreatoduodenectomy (PD) for familial adenomatous polyposis (FAP). This study analysed the results of PPTD in the Netherlands and reviewed the relevant literature.

Methods
All 26 patients who underwent PPTD for FAP in four centres in the Netherlands between January 2000 and January 2007 were compared with a group of 77 patients who had PD for ampulla of Vater adenocarcinoma at one centre during the same interval.

Results
Morbidity rates were similar after PPTD for FAP (16 patients, 62 per cent) and PD for ampulla of Vater adenocarcinoma (44 patients, 57 per cent) (P = 0·694). One patient (4 per cent) died after PPTD and two (3 per cent) after PD. A review of the literature, including patients from the present study, found that 71 patients had PPTD, with postoperative morbidity in 36 (51 per cent) and one death (1 per cent). In publications containing a total of 94 patients who underwent PD for FAP, 43 (46 per cent) developed complications and three (3 per cent) died.

Conclusion
PPTD has similar short-term results to PD in terms of morbidity and mortality.
Predictors of symptomatic and objective outcomes after surgical reintervention for failed antireflux surgery
Authors: Furnée E J B , Draaisma W A , Broeders I A M J , Smout A J P M , Vlek A L M , Gooszen H G 
Published: October 2008

Abstract

Background
Recurrent gastro-oesophageal reflux disease (GORD) and troublesome dysphagia after primary antireflux surgery are treated successfully by reoperation in 70 per cent of patients. Identifying predictors of outcome could allow selection of patients likely to benefit from further surgery. The aim was to identify such predictors in patients reoperated on for recurrent GORD or troublesome dysphagia.

Methods
Between 1994 and 2005, 83 patients (mean(s.d.) age 47·2(14·4) years; 47 men) with recurrent GORD and 47 (aged 50·7(13·4) years; 18 men) with troublesome dysphagia had further surgery. The predictive values of demographic, anatomical and manometric variables, and 24-h pH monitoring were analysed with respect to symptomatic and objective outcomes in each group.

Results
None of the factors included in a multivariable analysis predicted outcome after surgery for recurrent GORD. Independent predictors of symptomatic outcome after reoperation for dysphagia were amplitude of distal oesophageal contractions (odds ratio (OR) 1·613 (95 per cent confidence interval (c.i.) 1·087 to 2·393); P = 0·017), intrathoracic wrap migration (OR 0·077 (0·003 to 1·755); P = 0·108) and an abdominal approach (OR 0·012 (0·001 to 0·337); P = 0·009).

Conclusion
Low-amplitude distal oesophageal contractions, intrathoracic wrap migration and an abdominal approach were significant predictors of an unsuccessful symptomatic outcome after reoperation for troublesome dysphagia.
False-negative sentinel lymph node biopsy
Authors: van Wely B J , Smidt M L , de Kievit I M , Wauters C A P , Strobbe L J A 
Published: October 2008

Abstract

Background
The clinical significance of false-negative axillary sentinel lymph node (SLN) biopsy has yet to be established. The aim of this study was to assess the axillary recurrence rate and false-negative rate, to identify prognostic factors and to monitor survival.

Methods
A prospective registry of sentinel lymph node biopsy (SLNB) procedures performed between 1998 and 2004 was analysed. All nodes retrieved were examined by haematoxylin and eosin and immunohistochemical staining. Further surgical treatment was performed only for positive SLNs. Adjuvant treatment was given according to Dutch guidelines.

Results
Of 592 patients, 392 had a negative SLNB. After a median follow-up of 65 months, 11 patients developed axillary recurrence (2·8 per cent). Ten of these patients were primarily treated by simple mastectomy and therefore had no external-beam radiation therapy; no further prognostic factors could be identified. The false-negative rate was 6·9 per cent. The median time from SLNB to detection of the axillary recurrence was 27 months. The median follow-up after recurrence was 35 months, and one patient developed systemic disease. Pathology revision revealed two previously undetected micrometastases.

Conclusion
Axillary recurrence and false-negative rates after SLNB increase with longer follow-up.
The surgical application of point-of-care haemostasis and platelet function testing
Authors: Dickinson K J , Troxler M , Homer-Vanniasinkam S 
Published: October 2008

AbstractBackgroundDisordered coagulation complicates many diseases and their treatments, often predisposing to haemorrhage. Conversely, patients with cardiovascular disease who demonstrate antiplatelet resistance may be at increased thromboembolic risk. Prompt identification of these patients facilitates optimization of haemostatic dysfunction. Point-of-care (POC) tests are performed ‘near patient’ to provide a rapid assessment of haemostasis and platelet function.MethodsThis article reviews situations in which POC tests may guide surgical practice. Their limitations and potential developments are discussed. The paper is based on a Medline and PubMed search for English language articles on POC haemostasis and platelet function testing in surgical practice.ResultsPOC tests identifying perioperative bleeding tendency are already widely used in cardiovascular and hepatic surgery. They are associated with reduced blood loss and transfusion requirements. POC tests to identify thrombotic predisposition are able to determine antiplatelet resistance, predicting thromboembolic risk. So far, however, these tests remain research tools.ConclusionPOC haemostasis testing is a growing field in surgical practice. Such testing can be correlated with improved clinical outcome.
Randomized clinical trial of stapled haemorrhoidopexy performed under local perianal block versus general anaesthesia
Authors: Gerjy R , Lindhoff-Larson A , Sjödahl R , Nyström P-O 
Published: October 2008

Abstract

Background
The aim was to assess the feasibility of performing stapled haemorrhoidopexy under local anaesthesia.

Methods
Fifty-eight patients with haemorrhoid prolapse were randomized to receive local or general anaesthesia. The perianal block was applied immediately peripheral to the external sphincter. Submucosal block was added after applying the purse-string suture. Patients reported average and peak pain daily for 14 days using a visual analogue scale (VAS). They also completed anal symptom questionnaires before the operation and at follow-up. The surgeon assessed the restoration of the anal anatomy 3–6 months after surgery.

Results
The anal block was sufficient in all patients. The mean accumulated VAS score for average pain was 23·1 in the general anaesthesia group and 29·4 in the local anaesthesia group (P = 0·376); mean peak pain scores were 42·1 and 47·9 respectively (P = 0·537). Mean change in symptom load was also similar between the groups, with score differences of 7·0 in the general anaesthesia group and 6·1 in the local anaesthesia group. No patient had a recurrence of prolapse.

Conclusion
Perianal local block is easy to apply with a high degree of acceptability among patients. Postoperative pain, restoration of anatomy and symptom resolution were similar to that of stapled haemorrhoidopexy performed under general anaesthesia. Registration number: ISRCTN19930199 (http://www.controlled-trials.com).
Letter 1: Use of enoxaparin results in more haemorrhagic complications after breast surgery than unfractionated heparin (Br J Surg 2008; 95: 834–836)
Authors: Kittisupamongkol W 
Published: October 2008

Abstract
The Editors welcome topical correspondence from readers relating to articles published in the Journal. Responses should be sent electronically via the BJS website (www.bjs.co.uk). All letters will be reviewed and, if approved,appear on the website. A selection of these will be edited and published in the Journal. Letters must be no more than 250 words in length.
Synthesis of Isoxazolopyridobicyclooxacalix[4]arenes: A New Family of Heteracalixarene Systems
Authors: Ferrini Serena , Fusi Stefania , Giorgi Gianluca , Ponticelli Fabio 
Published: October 2008

AbstractA new family of isoxazolopyridobicyclooxacalix[4]arenes was obtained by reaction of dichloroisoxazolopyridines with phloroglucinol. X‐ray crystallography and density functional calculations were used for their structural determination and evaluation of their chemical properties. Their role as metal chelators was studied by mass spectrometry. This new family of heteracalixarenes is of potential interest for host–guest interactions. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Development and characterization of hepatitis C virus genotype 1-7 cell culture systems: Role of CD81 and scavenger receptor class B type I and effect of antiviral drugs # †
Authors: Gottwein Judith M. , Scheel Troels K. H. , Jensen Tanja B. , Lademann Jacob B. , Prentoe Jannick C. , Knudsen Maria L. , Hoegh Anne M. , Bukh Jens 
Published: October 2008

Abstract
Six major hepatitis C virus (HCV) genotypes and numerous subtypes have been described, and recently a seventh major genotype was discovered. Genotypes show significant molecular and clinical differences, such as differential response to combination therapy with interferon-α and ribavirin. Recently, HCV research has been accelerated by cell culture systems based on the unique growth capacity of strain JFH1 (genotype 2a). By development of JFH1-based intergenotypic recombinants containing Core, envelope protein 1 and 2 (E1, E2), p7, and nonstructural protein 2 (NS2) of genotype 6a and 7a strains, as well as subtype 1b and 2b strains, we have completed a panel of culture systems for all major HCV genotypes. Efficient growth in Huh7.5 cells depended on adaptive mutations for HK6a/JFH1 (6a/2a, in E1 and E2) and J4/JFH1 (1b/2a, in NS2 and NS3); viability of J8/JFH1 (2b/2a) and QC69/JFH1 (7a/2a) did not require adaptation. To facilitate comparative studies, we generated virus stocks of genotype 1–7 recombinants with infectivity titers of 103.7 to 105.2 50% tissue culture infectious dose/mL and HCV RNA titers of 107.0 to 107.9 IU/mL. Huh7.5 cultures infected with genotype 1–6 viruses had similar spread kinetics, intracellular Core, NS5A, and lipid amounts, and colocalization of Core and NS5A with lipids. Treatment with interferon-α2b but not ribavirin or amantadine showed a significant antiviral effect. Infection with all genotypes could be blocked by specific antibodies against the putative coreceptors CD81 and scavenger receptor class B type I in a dose-dependent manner. Finally, neutralizing antibodies in selected chronic phase HCV sera had differential effects against genotype 1–7 viruses. Conclusion: We completed and characterized a panel of JFH1-based cell culture systems of all seven major HCV genotypes and important subtypes and used these viruses in comparative studies of antivirals, HCV receptor interaction, and neutralizing antibodies. (Hepatology 2009.)
Steam absorption into films of aqueous solution of lithium bromide and lithium iodide mixture falling over a column of horizontal pipes
Authors: Kiyota Masanori , Morioka Itsuki , Kimoto Keisuke , Suekane Tetsuya 
Published: October 2008

AbstractTo improve absorption chiller performance, an aqueous solution of lithium bromide and lithium iodide mixture at the ratio of 1:0.7 was proposed for an absorbing medium since it has a higher solution limit than conventional lithium bromide solution. But the component lithium iodide solution has a higher equilibrium pressure than the lithium bromide solution. To investigate the absorption performance of the mixture liquid, experiments were carried out using a horizontal pipe column. Experimental range of the mass concentration was 62–66% for the mixture solution and 62–63% for the lithium bromide solution. The absorption rate of lithium bromide solution at 62% and 63% is almost equal to the mixture solution at 63% and 64%, respectively. Compared at the same concentrations, the mixture solution is inferior to the lithium bromide solution; at the maximum concentration, the mixture solution has about 20 to 50% higher absorption rates than the lithium bromide solution. Surface temperature of the falling films was measured by thermal video and used to determine the heat transfer coefficient and mass transfer coefficient, which becomes larger for the mixture solution than for the lithium bromide solution. This is due to the decreased viscosity of the mixture solution. © 2008 Wiley Periodicals, Inc. Heat Trans Asian Res, 37(7): 431–444, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/htj.20213
Identifying rotation and oscillation in surface tension measurement using an oscillating droplet method
Authors: Ozawa Shumpei , Koda Takuro , Adachi Masayoshi , Shiratori Suguru , Takenaga Noriaki , Hibiya Taketoshi , Watanabe Masahito 
Published: October 2008

AbstractWe proposed a new approach to identify the frequencies of droplet rotation and m=±2 oscillation that degrade the accuracy of surface tension measurement by an oscillating droplet method. Frequencies of droplet rotation and m=±2 oscillation can be identified by a phase unwrapping analysis of time dependence of the deflection angle for the maximum diameter of the droplet image observed from above. The present method was validated, using test data with given frequencies. © 2008 Wiley Periodicals, Inc. Heat Trans Asian Res, 37(7): 421–430, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/htj.20214
Frost formation on a bionic super‐hydrophobic surface under natural convection conditions
Authors: Gou Yunjun , Liu Zhongliang , Wang Jieteng , Cheng Shuiyuan 
Published: October 2008

AbstractA bionic super‐hydrophobic surface has a multiple micro‐nano‐binary structure (MNBS) similar to the lotus leaf surface microstructure. This kind of surface has a contact angle of water greater than 150° and a roll angle smaller than 5°. In this paper, the frost deposition phenomena on a bionic super‐hydrophobic surface were observed. The surface has many micro bumps and its contact angle is 162°. The formation of water droplets, the droplet freezing process, the formation of initial frost crystals and the frost layer structure on a cold bionic super‐hydrophobic surface under natural convection conditions were closely observed. The frost layer structure formed on the super‐hydrophobic surface shows remarkable differences to that on a plain copper surface: the structure is weaker, looser, thin, and easily removed and most importantly, it is of a very special pattern, a pattern similar to a chrysanthemum, a frost layer structure that has not been reported before to the best of the present authors knowledge. The experimental results also show that a super‐hydrophobic surface has a strong ability to restrain frost growth. The frost deposition on this bionic surface was delayed 55 minutes when compared with a plain copper surface under the conditions of a cold plate temperature of −10.1°C, air temperature of 18.4°C, and relative humidity of 40%. A theoretical analysis was also presented to explain the observed phenomena. © 2008 Wiley Periodicals, Inc. Heat Trans Asian Res, 37(7): 412–420, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/htj.20216
TCEB1 promotes invasion of prostate cancer cells
Authors: Jalava Sanni E. , Porkka Kati P. , Rauhala Hanna E. , Isotalo Jarkko , Tammela Teuvo L. , Visakorpi Tapio 
Published: October 2008

AbstractAmplification of the long arm of chromosome 8 is one of the most recurrent findings in prostate cancer and it is associated with poor prognosis. Several minimal regions of amplification suggest multiple target genes which are yet to be identified. We have previously shown that TCEB1, EIF3S3, KIAA0196 and RAD21 are amplified and overexpressed in prostate cancer and they are located in the 8q area. In this study, we examined the functional effects of these genes to prostate cancer cell phenotype. We overexpressed and inhibited the genes by lentivirus mediated overexpression and RNA interference, respectively. shRNA mediated TCEB1 silencing decreased significantly cellular invasion of PC‐3 and DU145 cells through Matrigel. TCEB1 silencing reduced the anchorage‐independent growth of PC‐3 cells. Similar effects were not seen with any other genes. When overexpressed in NIH 3T3 cells, TCEB1 and EIF3S3 increased the growth rate of the cells. Transcriptional profiling of TCEB1 silenced PC‐3 cells revealed decrease of genes involved in invasion and metastasis. Finally, we also confirmed here the overexpression of TCEB1 in hormone‐refractory prostate tumors. This study indicates that TCEB1 promotes invasion of prostate cancer cells, is involved in development of hormone‐refractory prostate cancer and is thereby a strong candidate to be one of the target genes for the 8q gain. © 2008 Wiley‐Liss, Inc.
How many cervical cancers are prevented by treatment of screen‐detected disease in young women?
Authors: Sasieni Peter , Castanon Alejandra , Parkin D. Max 
Published: October 2008

AbstractOthers have argued that as many as a third of women treated for high‐grade cervical intraepithelial neoplasia (CIN) would have developed cervical cancer in the absence of screening and treatment. Under various assumptions and using past data on CIN grade 3 (CIN3) registrations in England and Scotland, we estimate what cervical cancer rates would have been in the absence of screening. Data on registrations of cervical carcinoma in situ for England and Scotland were used to project the additional numbers of invasive cervical cancers that would have resulted had the carcinoma in situ not been treated. We compare the resulting cervical cancer rates (under different models) with rates recorded in Cancer Incidence in 5 Continents. In order for the projected rates in England and Scotland at ages 20–24 not to be exceptionally high compared to maximum recorded rates for each registry in Cancer Incidence in 5 Continents, the progression rate from CIN3 to invasive cancer in women aged 20–24 should not exceed 1% per year. Similar progression rates were reasonable for women aged 25–29. Under the previously accepted assumption of 4.33% progression per year, cervical cancer rates in women aged 20–29 in both England and Scotland would have been 2–5 times greater than any observed rate (other than one registry, based on just 4 cases). From this analysis, at most 1.5% of women treated (equivalent to 3% of CIN3 registrations) would have had cancer by age 25, whereas it is reasonable to assume that over half of them would have regressed by age 25. © 2008 Wiley‐Liss, Inc.
Cholinergic signaling through nicotinic acetylcholine receptors stimulates the proliferation of cervical cancer cells: An explanation for the molecular role of tobacco smoking in cervical carcinogenesis?
Authors: Calleja‐Macias Itzel E. , Kalantari Mina , Bernard Hans‐Ulrich 
Published: October 2008

AbstractWe have analyzed the expression of mRNAs encoding nicotinic acetylcholine receptors (nAChRs) in CaSki, SiHa and HeLa cell lines, which are derived from two squamous and one adenocarcinoma of the cervix, respectively. We detected with reverse transcription‐polymerase chain reaction mRNAs for ten of the 16 nAChR subunits, namely strong signals for alpha‐5, alpha‐7, alpha‐9, beta‐1 and epsilon, and weak signals for alpha‐4, beta‐2, beta‐4, gamma and delta. We confirmed the translation of alpha‐5 and beta‐1, corresponding to the two strongest RNA signals, in SiHa and HeLa cells by Western blotting, and the localization of these proteins to the plasma membrane by immunofluorescence. The beta‐1 subunit was detected membrane‐associated in normal and neoplastic squamous epithelia of the cervix in situ, but appeared to be absent from the underlying mesenchyme and even from adjacent columnar epithelia. These observations suggest that normal and neoplastic cervical squamous epithelial cells express several combinations of the pentameric nAChRs. We also measured that the proliferation of SiHa and HeLa cells is stimulated by nicotine. This indicates that cholinergic signaling under normal physiological conditions and stimulated by nicotine in tobacco users affects epithelial homeostasis and neoplastic progression at the cervix in a way similar to the known effects on epithelia of the mouth, the airways and the lung. Since tobacco smoking is established as a risk factor in cervical carcinogenesis, and since nicotine and its derivatives become concentrated in cervical mucus, nAChR‐dependent signaling is apparently an important molecular cofactor of human papillomavirus‐dependent cervical carcinogenesis. © 2008 Wiley‐Liss, Inc.
International liquidity swaps: is the Chiang Mai Initiative pooling reserves efficiently?
Authors: Kohlscheen E. , Taylor M. P. 
Published: October 2008

AbstractWe analyse the network of bilateral liquidity swaps (BSAs) among the ASEAN+3 countries. We find that the network has taken the correlation of capital flows in the region into account, in the sense that countries with lower correlation of reserve growth have engaged in larger BSAs. All else equal, a decimal point increase in the correlation of international reserve growth decreases the size of a bilateral swap agreement between 18% and 27%. Moreover, we find that the approximately $ 60 bn of BSAs have had a limited impact, if any, on government bond spreads so far. Finally, we identify potential gains from inter‐regional BSAs. Copyright © 2008 John Wiley & Sons, Ltd.
Convergence of integrins and EGF receptor signaling via PI3K/Akt/FoxO pathway in early gene Egr‐1 expression
Authors: Cabodi Sara , Morello Virginia , Masi Alessio , Cicchi Riccardo , Broggio Chiara , DiStefano Paola , Brunelli Elisa , Silengo Lorenzo , Pavone Francesco , Arcangeli Annarosa , Turco Emilia , Tarone Guido , Moro Laura , Defilippi Paola 
Published: October 2008

AbstractThe early gene early growth response (Egr‐1), a broadly expressed member of the zing‐finger family of transcription factors, is induced in many cell types by a variety of growth and differentiation stimuli, including epidermal growth factor (EGF). Here we demonstrate that Egr‐1 expression is mainly regulated by integrin‐mediated adhesion. Integrin‐dependent adhesion plays a dual role in Egr‐1 regulation, either being sufficient “per se” to induce Egr‐1, or required for EGF‐dependent expression of Egr‐1, which occurs only in adherent cells and not in cells in suspension. To dissect the molecular basis of integrin‐dependent Egr‐1 regulation, we show by FLIM‐based FRET that in living cells beta1‐integrin associates with the EGF receptor (EGFR) and that EGF further increases the extent complex formation. Interestingly, Egr‐1 induction depends on integrin‐dependent PI3K/Akt activation, as indicated by the decrease in Egr‐1 levels in presence of the pharmacological inhibitor LY294002, the kinase‐defective Akt mutant and Akt1/2 shRNAs. Indeed, upon adhesion activated Akt translocates into the nucleus and phosphorylates FoxO1, a Forkhead transcription factors. Consistently, FoxO1silencing results in Egr‐1‐increased levels, indicating that FoxO1 behaves as a negative regulator of Egr‐1 expression. These data demonstrate that integrin/EGFR cross‐talk is required for expression of Egr‐1 through a novel regulatory cascade involving the activation of the PI3K/Akt/Forkhead pathway. J. Cell. Physiol. 218: 294–303, 2009. © 2008 Wiley‐Liss, Inc.