bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations of remission status and lanreotide treatment with quality of life in patients with treated acromegaly
Authors: Hua Shih-Che , Yan Yuan-Horng , Chang Tien-Chun 
Published: November 2006

Objective: Acromegaly has an important impact on quality of life (QOL). The aim of this study was to evaluate the associations of remission status and lanreotide treatment with QOL in patients with treated acromegaly, by the newly developed disease-generated acromegaly QOL questionnaire (ACROQOL).
Design: Cross-sectional study.
Methods: Fifty-two patients with treated acromegaly were recruited to complete the Chinese version of the ACROQOL translated and validated from the English version. These patients were divided into controlled and uncontrolled groups based on the latest remission criteria and further subdivided into four groups according to the present treatment with lanreotide or not. Comparisons between groups were analyzed.
Results: There was no difference between controlled and uncontrolled groups in the ACROQOL scores of total score, both scales and psychological subscales. However, in the controlled group, present treatment with lanreotide, in comparison with no treatment, showed worse ACROQOL scores in total score (P = 0.021), psychological scale (P = 0.011), psychological subscale ‘appearance’ (P = 0.032) and ‘personal relations’ (P = 0.010).
Conclusions: The lanreotide treatment was negatively associated with QOL in biochemically controlled acromegalic patients, especially in the psychological aspect.
The incidence of second primary tumors in thyroid cancer patients is increased, but not related to treatment of thyroid cancer
Authors: Verkooijen Robbert B T , Smit Jan W A , Romijn Johannes A , Stokkel Marcel P M 
Published: November 2006

Objective: The aim of the present study is to assess the prevalence of second primary tumors in patients treated for thyroid cancer. Furthermore, we wanted to assess the standardized risk rates for all second primary tumors, but especially for breast cancer, as data in the literature indicate an excessive risk in differentiated thyroid cancer (DTC) patients for this tumor.
Materials and methods: We included consecutive patients, who received ablation treatment with I-131 at the Leiden University Medical Center between January 1985 and December 1999 (n = 282). The mean period of follow-up was 10.6 ± 4.1 years.
Results: Thirty-five of the 282 patients (12.4%) had a second primary tumor (SPT), either preceding or following the diagnosis of thyroid cancer. Five other patients had three primary tumors, including DTC. As a result, 40 additional tumors were found in this group, revealing an overall prevalence of 14.2%. Twenty tumors (7.1%) preceded the thyroid cancer with a mean interval of 5.7 years (range: 0.5–22.0 years), whereas 20 tumors (7.1%) occurred after this tumor with a mean interval of 6.7 years (range: 1.0–15.0 years). In 13 female patients, breast cancer was found as SPT. The standardized incidence rate (SIR) for all cancers after the diagnosis of DTC in this study population was not increased (1.13; confidence interval (CI): 0.68–1.69). However, we found an increased SIR of 2.26 (CI: 1.60–3.03) for all cancers either following or preceding DTC, which is mainly caused by a SIR of 3.95 (CI: 2.06–6.45) for breast cancer.
Conclusion: Patients with DTC have an overall increased standardized incidence rate for second primary tumors, but not for second primary tumors following I-131 therapy. These findings suggest a common etiologic and/or genetic mechanism instead of a causal relation.
Thiamine transporter mutation: an example of monogenic diabetes mellitus
Authors: Alzahrani Ali S , Baitei Essa , Zou Minging , Shi Yufei 
Published: November 2006

Objective: Thiamine-responsive megaloblastic anemia (TRMA) is a rare syndrome characterized by diabetes mellitus (DM), anemia, and sensorineural deafness. We describe the clinical course and the molecular defect of a young woman who was diagnosed to have this syndrome.
Case: The patient is an 18-year-old girl whowas born to non-consanguous parents. She was noted to be deaf-mute in the first year of life. She was diagnosed with DM at the age of 9 months and with severe anemia at the age of 2 years. An extensive work up could not identify the cause. She was treated with blood transfusions every 3–4 weeks for the past 16 years. A diagnosis of TRMAwas suspected and the patient was treated with thiamine hydrochloride. Hemoglobin and platelets increased to normal values after a few weeks of thiamine therapy. Diabetic control significantly improved but she had no noticeable changes in the deafness.
Methods: Peripheral blood DNAwas extracted from the patient, her mother, aunt, and a healthy sister. Exons and exon–intron boundaries of the thiamine transporter gene SLC19A2 were PCR amplified and directly sequenced.
Results: A G515C homozygous mutation was identified in the SLC19A2 gene of the patient. This mutation changes Gly to Arg at codon 172 (G172R). The mother, an aunt, and a sister had a heterozygous G172R mutation.
Conclusions: Mutations in thiamine transporter gene, SLC19A2, causes a rare form of monogenic diabetes, anemia, and sensorineural deafness. Thiamine induces a remarkable hematological response and improvement in the diabetic control but has no effect on deafness.
The analysis of quantitative expression of somatostatin and dopamine receptors in gastro-entero-pancreatic tumours opens new therapeutic strategies
Authors: O’Toole Dermot , Saveanu Alexandru , Couvelard Anne , Gunz Ginette , Enjalbert Alain , Jaquet Philippe , Ruszniewski Philippe , Barlier Anne 
Published: November 2006

Objective: Somatostatin (sst) are present in the majority of gastro-entero-pancreatic (GEP) tumours. Effects of somatostatin receptor (sst) analogues are partial and of limited duration. Cell lines derived from GEP express dopaminergic receptors D2. New chimeric analogues simultaneously recognising sst2 and sst5 or sst2 and D2 have additive effects in inhibition of GH and prolactin secretion in pituitary adenomas. Our aim was to quantify the expression of sst and D2 mRNA in human GEP tumours.
Design and methods: mRNA expression of sst1, sst2, sst3 and sst5 as well as D2, was analysed using real-time PCR (TaqMan probe) in a series of 35 patients with GEP tumours (pancreas (n = 19) and intestinal (n = 16)). Levels of expression were compared with a group of 13 somatotroph adenomas.
Results: All GEP tumours express sst1, sst2 and D2. Expression of sst3 and sst5 was observed in 89 and 76% of tumours respectively with highly variable levels. sst2 mRNA expression was higher in nonfunctional tumours (P < 0.009) and sst5 was higher in pancreatic than in intestinal tumours (P < 0.02). Whereas sst2 levels were similar between GEP and somatotroph tumours, levels of sst5 and D2 were higher in the former (394.9 ± 156.1 × 10−2 vs 69.7 ± 19.5 × 10−2 copy/copy β-Gus (P < 0.0036) and 519.6 ± 121.2 × 10−2 vs 50.0 ± 21.6 × 10−2 copy/copy β-Gus (P < 0.0001) respectively). In small tumours ( < 30 mm), sst2 density appeared as a crucial parameter in somatostatin receptor scintigraphy results, whereas in big tumours, a consistent bias in SRS results was introduced by the size. In pancreatic GEP, high-level sst3 expression was found in tumours with more active angiogenesis (higher microvessel density and vascular endothelial growth factor expression (P < 0.03)).
Conclusions: GEP tumours co-express sst2 and D2 in 100% of cases and sst5 in 89% thus supporting the testing of bi-specific agonists (sst2/sst5 or sst2/D2) in these tumours.
Protective effects of vitamin E against CCl4-induced hepatotoxicity in rabbits
Authors: Pawłowska-Góral K. , Wardas M. , Wardas P. , Rzepecka-Stojko A. 
Published: November 2006

AbstractThe influence of CCl4 on the activity of superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR), the value of the total antioxidant status (TAS), and the concentration of malonic dialdehyde (MDA) and glutathione (GSH) was monitored in plasma or whole blood of rabbits. The administration of CCl4 caused the increase of the SOD activity to approximately 150 % and the decrease in the activity of GPx and GR by about 50 %. These changes were accompanied with the increase in TAS value and MDA concentration and the decrease of GSH concentration. The effect of CCl4 was suppressed by the previous 7 days lasting or simultaneous administration of vitamin E. Oxidative stress caused by CCl4 was accompanied by the development of reactive oxygen forms, especially superoxide radical anion.
Effect of microwave irradiation on the reactivity of chloroarenes in Suzuki—Miyaura reaction
Authors: Poláčková V. , Toma Š. 
Published: November 2006

AbstractSimple catalytic systems for the Suzuki—Miyaura reaction of aryl chlorides under microwave conditions were tested. Microwave irradiation facilitated the reaction course. The catalyst, base, and solvent effect were studied and two reaction systems offered reasonable to high yields within a short time.
Kinetics of extraction of coal-tar pitch components with supercritical carbon dioxide
Authors: Marković S. , Marković Z. , McCrindle R. , Simonović B. 
Published: November 2006

AbstractThe extraction of a coal-tar pitch with supercritical carbon dioxide was performed under optimal pressure, flow rate, and three different constant temperatures. The extraction kinetics was examined for each temperature and it was surprisingly found that the extraction rate of most components was governed by the first-order kinetics. It was assumed that this deviation from typical models of supercritical fluid extraction kinetics was caused by high pitch concentrations and low solubilities of the components.
Mechanism of photocatalytic oxidation of gaseous ethanol
Authors: Shao C. , Pan D. , Zhang R. , Hou H. 
Published: November 2006

AbstractA photocatalytic film reactor with a titanium dioxide film was used for oxidation of gaseous ethanol at 253.7 nm. The influences of partial pressures of oxygen and water vapour in different carrier gases were studied. The rate of photocatalytic oxidation of ethanol was significantly affected by the content of oxygen but water vapour had no effect. It was suggested that the photocatalytic transformation of ethanol follows a direct oxidation mechanism where the interaction of ethanol with positive hole gives first cationic free radical of ethanol, which is converted by multipathway reactions with oxygen to acetaldehyde, ethyl formate, and ethyl acetate.
A Tandem, Nitroalkene Conjugate Addition/[3+2] Cycloaddition Approach to the Synthesis of the Pentacyclic Core of (±)‐Scandine
Authors: Denmark Scott E. , Cottell Jeromy J. 
Published: November 2006

AbstractThe complete pentacyclic core of the melodinus alkaloid scandine has been synthesized. The synthetic strategy features two key steps: (1) a tandem nitroalkene conjugate addition/[3+2] cycloaddition of the resulting silyl nitronate and (2) an intramolecular Heck reaction of an aryl iodide with a γ‐disubstituted allylic alcohol which set a highly congested, quaternary stereogenic center with the concomitant formation of an aldehyde. Intramolecular reductive amination with this aldehyde completed the pentacyclic core.
Asymmetric Catalysis in the [2+2+2] Cycloaddition of Arynes and Alkynes: Enantioselective Synthesis of a Pentahelicene
Authors: Caeiro Jorge , Peña Diego , Cobas Agustín , Pérez Dolores , Guitián Enrique 
Published: November 2006

AbstractThe use of BINAP‐based palladium(0) catalysts in the reaction of 7‐methoxy‐1,2‐didehydronaphthalene (2) and dimethyl acetylenedicarboxylate (DMAD) affords non‐racemic 9,12‐dimethoxypentahelicene 1 with reasonable ees, among other cycloaddition products. This is the first example of an enantioselective, metal‐catalyzed cycloaddition involving arynes.
Palladium‐Catalyzed Intramolecular [3C+2C] Cycloaddition of Alkylidenecyclopropanes to Allenes
Authors: Trillo Beatriz , Gulías Moisés , López Fernando , Castedo Luis , Mascareñas José L. 
Published: November 2006

AbstractAllenes are useful and versatile two‐carbon partners in palladium catalyzed [3C+2C] intramolecular cycloadditions with alkylidenecyclopropanes enabling the preparation of dienyl bicyclo[3.3.0]octane adducts with good yields and high diastereoseletivity.
Stereoselectivity in Metal Carbene Addition to a Carbon‐Carbon Triple Bond Tied to the Reactant Diazoacetate Through a Chiral Linker
Authors: Doyle Michael P. , Weathers Thomas M. , Wang Yuanhua 
Published: November 2006

AbstractThe trajectory of a carbon‐carbon triple bond onto a metal carbene for cyclopropene formation is opposite to that of a carbon‐carbon double bond in the same system. Diazoacetates prepared from the butane‐2,3‐diacetals (BDA) of (L)‐ and (D)‐threitol were employed to examine diastereoselectivity in cyclopropenation. The absolute configuration of the predominant isomer was opposite in intramolecular metal carbene additions to propargyl and allyl substituents. Diastereoselectivities in the dirhodium(II) carboxamidate‐catalyzed diazo decomposition reactions are as high as 99:1 with match/mismatch selectivites for substrate and catalyst, dependent on catalyst configuration, and are favored in the order: Rh2(MEPY)4>Rh2(MEOX)4>Rh2(MEAZ)4> Rh2(MPPIM)4. The reactions catalyzed by the Cu(CH3CN)4PF6/PhBox system produce the same set of diastereoisomers in a complimentary match/mismatch selectivity that also reaches 99:1.
Conceptual, Qualitative, and Quantitative Theories of 1,3‐Dipolar and Diels–Alder Cycloadditions Used in Synthesis
Authors: Ess Daniel H. , Jones Gavin O. , Houk K. N. 
Published: November 2006

AbstractThe application and performance of conceptual and qualitative theories and quantitative quantum mechanical methods to the study of mechanism, reactivity, and selectivity of 1,3‐dipolar and Diels–Alder cycloadditions are reviewed. This review emphasizes the application of conceptual density functional theory (DFT) for predicting reactivity and regioselectivity, and highly accurate quantum mechanical methods for predicting barrier heights and reaction energetics. Applications of computations to solvation effects, metal and organocatalysis, are also described.
Convergent Synthesis of Azabicycloalkenones using Squaric Acid as Platform
Authors: Yamamoto Yoshihiko , Kuwabara Shoji , Hayashi Hiroki , Nishiyama Hisao 
Published: November 2006

AbstractThe synthesis of azabicycloalkenones bearing a vinylogous amide moiety was achieved by means of the rhodium‐catalyzed decarbonylative cycloaddition of cyclobutenediones with a pendant alkene. The starting cyclobutenediones were efficiently prepared from appropriate squaric acid monoesters and N‐benzylalkenylamines under microwave heating conditions.
T‐cell receptor gamma and delta gene rearrangements and junctional region characteristics in south Indian patients with T‐cell acute lymphoblastic leukemia
Authors: Sudhakar Natarajan , Nancy Nirmala Karunakaran , Rajalekshmy Kamalalayam Raghavan , Ramanan Ganapathi , Rajkumar Thangarajan 
Published: November 2006

AbstractClonal T‐cell receptor (TCR) gamma and delta gene rearrangements were studied in 40 T‐ALL cases (pediatrics, 29; adults, 11) using PCR with homo‐heteroduplex analysis. At least one clonal TCRG or TCRD rearrangement was detected in 34 (85%) cases. TCR gamma (TCRG) rearrangement was detected in 25 (62.5%) cases that included 16 (55%) pediatrics and 9 (81.8%) adults. TCR delta (TCRD) rearrangement was detected in 14/40 (35%) cases, which included 12 (41%) pediatrics and 2 (18%) adults. The frequency of VγI‐Jγ1.3/2.3 was significantly more in adults than pediatrics (81.8% vs. 41.3%, P = 0.02). In TCRD, Vδ1‐Jδ1 was rearranged in 10 (25%) cases. The surface membrane CD3 positive cases are significantly associated with absence of TCRD rearrangements (surface membrane CD3+ TCRδ− 84% vs. surface membrane CD3− TCRδ− 48%, P value = 0.03). Junctional region sequence analyzed with 10 cases each, of TCRG and TCRD, revealed an average junctional region of 7.4 nucleotides (range 2–18 nucleotides) in TCRG and 27 nucleotides (range 14–42 nucleotides) in TCRD‐complete rearrangements. In TCRG, trimming at the ends of Vγ and Jγ germline nucleotides resulted in deletion, on an average of 9.2 nucleotides. In TCRD, deletion of nucleotides of the Vδ and Jδ gene segments on an average was 3.5 nucleotides. The junctional region of TCRD is more diverse than TCRG; nevertheless, the frequency of TCRG was more than that of TCRD and hence we rely more on TCRG clonal markers to quantitate the minimal residual disease in T‐ALL. Am. J. Hematol., 2007. © 2006 Wiley‐Liss, Inc.
Pathological splenic rupture: A rare complication of chronic myelomonocytic leukemia
Authors: Goddard Shannon Lynn , Chesney Alden E. , Reis Marciano D. , Ghorab Zeina , Brzozowski Mike , Wright Frances C. , Wells Richard A. 
Published: November 2006

AbstractChronic myelomonocytic leukemia (CMML) is an uncommon disorder characterized by monocytosis of the peripheral blood, absence of the Philadelphia chromosome, fewer than 20% blasts, and one or more lineages showing dysplastic features. Splenomegaly is frequently seen and may be massive. A 56‐year‐old man with stable CMML and moderate splenomegaly presented to the emergency department with generalized abdominal pain and abrupt drop in hemoglobin. Abdominal imaging revealed splenic rupture and emergency splenectomy was undertaken, with complete recovery. Atraumatic rupture of the spleen has rarely been reported as a complication of CMML or other myelodysplastic disorders. This report should alert physicians to consider this diagnosis in patients with CMML and acute abdominal pain. Am. J. Hematol., 2007. © 2006 Wiley‐Liss, Inc.
A new investigation with the salting‐out effect on emulsifier‐free emulsion polymerization of methyl methacrylate
Authors: Can Seda , Tanrisever Taner 
Published: November 2006

AbstractThe effects of the various salts onto the emulsifier‐free emulsion polymerization of methyl methacrylate (MMA) were investigated. It was found that the kind and amount of the salts were very effective on the polymerization even onto the polymeric products. It is known that the ionic strength of the electrolyte is effective for the polymerization. However, our investigation with the same ionic strength of different electrolyte produced the different effect on the polymerization. It was found that the Stokes radiuses of ions are very important for the reaction kinetics and type of the product. At the same electrolyte concentration, as increased Stokes radii of cation of salts that not react (the fragments of initiator, ions, etc.) in polymerization, polymerization rate and average molecular weight of polymer decreased, polymer particle diameter increased. In the case of Br− and SO4= the anions of the salt are also demonstrated some unexpected reactions. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 103: 2494–2500, 2007
Blending of NR/BR/EPDM by reactive processing for tire sidewall applications. III. Assessment of the blend ozone‐ and fatigue‐resistance in comparison with a conventional NR/BR compound
Authors: Sahakaro Kannika , Datta Rabin N. , Baaij Johan , Noordermeer Jacques W. M. 
Published: November 2006

AbstractThe NR/BR blend compound formulations for tire sidewall applications contain a set of stabilizers added to prevent degradation mainly due to oxygen, ozone, and heat. 6PPD is the most effective and widely used antiozonant in tire compounds, but is a highly staining material causing a surface discoloration of the tire sidewall. Incorporation of 30 phr EPDM into blends of NR/BR improves the ozone resistance to the required level, without the need of 6PPD. The first two parts of this series have described a reactive processing technique applied to enhance the covulcanization and blend homogeneity, together with their characterization. In the present article, the properties of the NR/BR/EPDM blends prepared by both reactive and straight mixing are tested in comparison with those of equivalent conventional NR/BR compounds. The reactive NR/BR/EPDM blend vulcanizates show excellent tensile strength, elongation at break, tear strength, fatigue‐to‐failure, and ozone resistance in both static and dynamic conditions. The properties are equivalent or even superior to those of the conventional NR/BR tire sidewall compounds. The simple straight mixed NR/BR/EPDM blend vulcanizates distinctively possess inferior mechanical properties compared to those of the reactive mix. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 103: 2555–2563, 2007
Preparation, crystallization, and spinnability of poly(ethylene terephthalate)/silica nanocomposites
Authors: Zheng Hao , Wu Jialin 
Published: November 2006

AbstractPoly(ethylene terephthalate) (PET)/silica nanocomposites were successfully prepared by in situ polymerization. Silica nanoparticles were uniformly dispersed in the process of polymerization. By means of hot‐stage polarization microscope and DSC, the influence of nanosilica on the crystallization of PET/silica nanocomposites has been clarified. The results show that nanosilica does not behave as a nucleating agent in PET but postpones the appearance of crystallite. This phenomenon is very favor to improve spinnability. The investigation on melt spinning of PET/silica nanocomposites also shows that it is advantageous to spinning with descending the spinning temperature. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 103: 2564–2568, 2007
Intercalation of conducting poly(N‐propane sulfonic acid aniline) in V2O5 xerogel
Authors: Zhao Jing , Wang Gengchao , Li Xingwei , Li Chunzhong 
Published: November 2006

AbstractPoly(N‐propane sulfonic acid aniline) (PSPAN) can be formed between the lamellas of V2O5 xerogel by in situ oxidative polymerization/intercalation of N‐propane sulfonic acid aniline in the presence of air (V2O5 being the oxidation agent). The PSPAN/V2O5 nanocomposites were characterized by XRD, TEM, TGA, FTIR, UV–vis‐NIR, and conductivity measurement. The results show that the V2O5 maintains lamellar structure, but its interlayer spacing has increased from 1.18 to 1.31 nm. The FTIR spectra indicate that there is interaction between negatively charged oxygen of the sulfonic group of PASPN and the vanadium ion in V2O5 matrix. The electrical conductivity of PSPAN/V2O5 nanocomposite reached the value of 1.2 × 10−2 S/cm, which is 104 times higher than that of the V2O5 xerogel, and is 102 times more than that of the PSPAN. It was found that the aging in air facilitated the chain growth of PSPAN between the V2O5 lamellas, resulting in the increase of the electrical conductivity. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 103: 2569–2574, 2007
Synthesis and characterization of cage octa(aminopropylsilsesquioxane)
Authors: Zhang Zengping , Liang Guozheng , Lu Tingli 
Published: November 2006

AbstractThe compound of cage octa(aminopropylsilsesquioxane) (POSS‐NH2) was prepared in higher yield by the hydrolysis and polycondensation of trifunctional monomer H2NCH2CH2CH2Si(OC2H5)3 in the mixture of solvents acetonitrile and 1‐propanol, with tetraethyl ammonium hydroxide (Et4NOH) as the catalyst. The effects of various parameters influencing the reaction, such as monomer concentration, nature of solvents, and the content of catalyst, were investigated. Results showed that the better values of these reactive factors were nH2O/nXSiY3 = 8–9/1 (molar ratio), nEt4NOH/nXSiY3 = 0.0045 (molar ratio), respectively. The use of acetonitrile as a solvent favors the deposition and formation of the product. The existence of the higher boiling pointing 1‐propanol favors the higher reaction temperature, which accelerates the formation of octamer, reduces the reaction time and eventually increases the yield. The cage structure and its formula (H2NCH2CH2CH2)8Si8O12 of the synthetic compound were characterized by FTIR, MS, 1H, and 29Si NMR. TG curve of POSS‐NH2 shows that the cage‐like compound has high decomposition temperature and higher thermal residue than the theoretical values during the thermal processing. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 103: 2608–2614, 2007