bluuebunny/crossref_metadata_2025_split huggingface dataset:
Conservation surgery for radiation‐failure carcinoma of the glottic larynx
Authors: Shah Jatin P. , Loree Thom R. , Kowalski Luiz 
Published: February 2007

AbstractA consecutive series of 28 patients treated by conservation surgery of the larynx for radiation‐failure, recurrent rT1and T2(postradiotherapy staging) glottic squamous cell carcinoma treated at Memorial Sloan‐Kettering Cancer Center from 1966 to 1983 is reviewed. The majority of patients were men with the age ranging from 46 to 76 years. The disease‐free interval ranged from 0 to 113 months (median, 8.5 months). The stage at presentation was rT1in 25 patients and rT2in 3 patients. Surgery consisted of cordectomy (7 patients), hemilaryngectomy (18), and extended hemilaryngectomy (3). There was no operative mortality. Local recurrence developed in 8 patients (28.5%), cervical metastasis in 2, and distant metastasis in 1. Only 3 patients were salvaged by further treatment. The rate of local control was influenced by positive surgical margins. Overall, voice preservation was achieved in 75% of patients. The ultimate local control was 82.1% during a follow‐up period that ranged from 1.3 to 16.7 years (median, 6.3 years). The actuarial survival at 5 and 10 years was 73% and 71% following conservation surgery of the larynx.
Recurrent pleomorphic adenomas of the parotid gland
Authors: Myssiorek David , Ruah Carlos B. , Hybels Roger L. 
Published: February 2007

AbstractTwenty‐seven patients with recurrent pleomorphic adenomas of the parotid gland were seen. This study confirms that superficial parotidectomy with identification and dissection of the facial nerve greatly decreases the incidence of recurrent benign pleomorphic adenoma, and, in the small number that recur, are easier to cure. All lumps in the parotid area should be approached in the same manner, with the surgeon prepared to isolate the facial nerve and perform superficial parotidectomy. This technique is successful because it avoids dissection near the tumor capsule, which is the major cause of recurrence. The procedure recommended for treatment of patients to remove the first recurrent tumor is total parotidectomy and excision of the previous scar. This vigorous approach is dictated by the increasing difficulty of removing further recurrent tumors. Only 67% of patients with recurrent tumors ultimately achieve a tumor‐free status. Experienced surgeons can preserve the facial nerve even after multiple operations.
Cystic parotid masses in HIV infection
Authors: Sperling Neil M. , Lin Pi‐Tang , Lucente Frank E. 
Published: February 2007

AbstractCystic enlargement of the parotid gland is a newly described manifestation of infection with human immunodeficiency virus (HIV). A review of 15 such patients with respect to clinical presentation, natural history, and management is presented. Follow‐up ranges from 1 to 27 months, averaging 10 months. In 47% of the patients, parotid swelling was the chief complaint leading to the diagnosis of HIV infection. T‐cell analysis revealed the tendency for this lesion to occur in the early stages of immunodeficiency when T‐cell counts are high. Histologic examination revealed findings resembling benign lymphoepithelial lesion. It is felt that these lesions are a local manifestation of a systemic disease and treatment should be tailored with this in mind. Surgical excision may not be necessary. Fine‐needle aspiration (FNA) was found to be useful diagnostically and therapeutically. Recognition of this entity is essential for the head and neck specialist in providing an early diagnosis of HIV infection.
Sudden dysphonia due to parathyroid apoplexy: A rare case of recurrent laryngeal nerve palsy
Authors: Ben‐Shlomo Izhar , Zohar Shmuel , Turani Hanna , Cozacov Carlos 
Published: February 2007

AbstractA case is presented of sudden onset dysphonia in a 59‐year‐old man caused by acute vocal cord paralysis due to bleeding within a hyperplastic lower right parathyroid gland. There were no laboratory findings of hyperparathyroidism nor coagulation disorder. Acute onset of vocal cord paralysis is rarely associated with benign processes; the current case is the first associated with parathyroid hyperplasia.
Folded, bipaddled composite flap in head and neck reconstruction
Authors: Bhathena Hosi M. , Kavarana Naozer M. 
Published: February 2007

AbstractA series of 34 patients repaired by folded, bipaddled composite flaps for head and neck cancer surgical defects is presented. Pectoralis major composite flap was used in 33 patients on musculovascular pedicle and 1 patient had a latissimus dorsi composite flap free‐tissue transfer. The pectoralis major rib, osteomyocutaneous flap was utilized in 6 patients who had lesions of the mouth floor and anterior mandibular arch. The incorporated rib was used as a vascularized bone graft for the stability of mandibular fragments. Thus, one regional composite flap used in bipaddled fashion enabled the reconstruction of mucosal, skin, and mandibular arch defects.
Mucinous carcinoma of the external auditory canal: Case report
Authors: Kitamura Ken , Asai Masao , Kubo Toshiro , Harii Kiyonori , Hasegawa Akio 
Published: February 2007

AbstractAn unusual case of a mucinous carcinoma originating from the external auditory canal in a 70‐year‐old man is described. Multiple metastatic lesions also appeared in the parotid gland. After a local excision of the primary lesion, the tumor was seen to extend anterosuperiorly along the middle cranial cavity dura. The occurrence of this tumor is exceedingly rare, and, to our knowledge, this is the first report of a mucinous carcinoma of the external auditory canal. The clinical pictures of this tumor and the histological findings are discussed with reference to other reports.
Carcinosarcoma of the nasal cavity and paranasal sinuses
Authors: Shindo Maisie L. , Stanley Robert B. , Kiyabu Milton T. 
Published: February 2007

AbstractMalignant neoplasms consisting of an epithelial element and 1 or more nesenchymal components are variously termed teratocarcinosarcoma, carcinosarcoma, malignant teratoma, spindle cell carcinoma, and pseudosarcomatous squamous cell carcinoma. Carcinosarcoma, consisting of a malignant epithelial element and a single malignant mesenchymal component, is extremely rare in the sinonasal tract. We report a case of carcinosarcoma involving the nasal cavity, paranasal sinuses, and anterior cranial fossa. Rapid growth and extensive local destruction are prominent features of this tumor, emphasizing the need for early diagnosis and prompt institution of aggressive therapy. The clinical presentation, pathologic features, and clinical course are detailed.
Objective assessment of swallowing function in head and neck cancer patients
Authors: Muz Jaroslaw , Mathog Robert H. , Hamlet Sandra L. , Davis Lawrence P. , Kling George A. 
Published: February 2007

AbstractSwallowing function was evaluated with scintigraphy in 37 patients with head and neck cancer. The patients were examined before and during the course of either surgery, chemotherapy, and/or radiotherapy. A total of 118 scintigraphic studies were performed. Scintigraphic results of bolus flow and aspiration were correlated with clinical findings. Both scintigraphic and clinical studies indicated a worsened swallowing function in 12 patients. These same studies indicated improvement of swallowing in another 13 patients. In 11 patients, both studies revealed either no apparent change or mixed changes in swallowing function after the course of therapy. In only 1 patient was there disagreement between the scintigraphic and clinical assessment of swallowing function. It is our opinion that scintigraphy is a useful method for objective assessment of swallowing function during and after the course of treatment of head and neck cancer patients.
Analysis of the morbidity associated with immediate microvascular reconstruction in head and neck cancer patients
Authors: Schusterman Mark A. , Horndeski Gary 
Published: February 2007

AbstractFree tissue transfer has become an important adjunct in the reconstruction of head and neck cancer patients. Despite the success, the added time required to perform free flap reconstructions continues to be a concern for some head and neck surgeons. In order to investigate whether this added time increases the risk of medical complications to the patient, 20 consecutive free flap patients were compared to 20 age‐, site‐, and histology‐matched controls. These patients were analyzed for demographic data, American Society of Anesthetic risk scores, stage, tumor site, and pre‐ and postoperative medical problems. The mean occurrence of medical problems preoperatively was 1.1 occurrences per patient for the flap group and 1.5 occurrences per patient for the control group. Postoperatively, there were 0.75 occurrences per flap group and 0.9 occurrences for the control group. Neither of these was statistically significant. The length of hospitalization was 13.5 days for the control group and 15.9 days for the flap group. Again, this was not statistically significant. The only significant statistic difference was the length of the procedure: 6.95 hours for the control group and 11.0 hours for the flap group, which had a p value of less than 0.001. In conclusion, this study indicates that length of procedure alone should not be a determining factor in deciding whether or not to use immediate microvascular reconstruction in head and neck cancer patients.
Microvascular free tissue reconstruction following Mohs' micrographic surgery for advanced head and neck skin cancer
Authors: Ahn Sang Tae , Hruza George J. , Mustoe Thomas A. 
Published: February 2007

AbstractSeven consecutive patients from 1986 through 1989 for 8 extensive recurrent and/or irradiated skin cancers of the face and scalp are retrospectively evaluated. One patient was treated by conventional surgical margins, and the limitations of this method in sampling margins are compared to the Mohs' micrographic surgery (MMS) used for the other 6 patients. All were treated with free flaps without flap loss or major complications in spite of advanced age. The advantages of an interdisciplinary approach to achieve maximum cure rates, optimal reconstruction, and minimizing anesthesia time are discussed.
Incisional or excisional neck‐node biopsy before definitive radiotherapy, alone or followed by neck dissection
Authors: Ellis Eric R. , Mendenhall William M. , Rao P. V. , McCarty Patricia J. , Parsons James T. , Stringer Scott P. , Cassisi Nicholas J. , Million Rodney R. 
Published: February 2007

AbstractAn analysis of 508 patients (660 heminecks) with head and neck squamous cell carcinoma and clinically positive neck nodes who were treated with radiotherapy alone to the primary lesion (with or without a neck dissection) was conducted to determine if open neck‐node biopsy before definitive treatment adversely affected the probability of control of neck disease, the risk of distant metastasis, or the cause‐specific survival rate. The prognostic factors analyzed included biopsy status of the neck, N stage, neck treatment, node mobility, node location, T stage, primary site, and control of disease above the clavicles. Sixty‐six patients who had undergone an open neck‐node biopsy before definitive radiotherapy were compared with a control group of 442 patients who did not undergo a neck‐node biopsy; no detrimental effect of the biopsy on neck control, distant metastasis, or cause‐specific survival was demonstrated. We conclude that the potential adverse effect of violating the neck before definitive treatment cannot be demonstrated if radiotherapy is the next step in the patient's management.
Irradiation and free tissue transfer in head and neck cancer
Authors: Jose Baby , Banis Joseph , Flynn Michael , Lindberg Robert , Spanos William J. , Paris Kristie , Rohm Janet 
Published: February 2007

AbstractThe aim of this study was to analyze the effects of surgery, irradiation, and free tissue transfer in locally advanced head and neck cancer patients. Forty‐one patients with head and neck cancer were treated with surgery, irradiation, and free tissue transfer for reconstruction from 1977 to 1987. The age range was 38 to 78 years with a median age of 61. Patients were staged using the AJCC (1978) staging system. Eighty‐four percent of the patients were in stage III or IV. The common sites of primary tumors were the oral cavity (22) and oropharynx (10). Forty patients had squamous cell carcinoma and 1 patient had basal cell carcinoma. Six patients had preoperative irradiation, and the rest had postoperative irradiation. The most common surgical procedures were partial glossectomy and neck dissection (17 patients) and wide excision of the primary and neck dissection (17 patients). The most common types of free tissue transfer were dorsalis pedis (13 patients) and scapular flaps (6 patients). The primary site was controlled in 22 patients (54%) and the neck in 36 patients (88%). Three patients (7.3%) had flap failure which required further surgical management. Eighteen patients are living with no evidence of disease with a median follow‐up of 18 months (5‐101 months), 10 patients are living with disease with a median follow‐up of 9 months (3‐40 months), 9 patients are dead of disease with a median survival of 13 months (6‐54 months), and 4 patients are lost for follow‐up. This study shows that free tissue transfer before or after irradiation is of benefit with few complications.
Intubation granuloma of the larynx: Successful eradication with low‐dose radiotherapy
Authors: Harari Paul M. , Blatchford Steven J. , Coulthard Stanley W. , Cassady J. Robert 
Published: February 2007

AbstractPostintubation granuloma of the larynx is a well recognized entity, which has accompanied the increased use of endotracheal intubation for general anesthesia. Voice rest, corticosteroids, antibiotics, antacids, and surgical removal are generally accepted conventional therapies, although select cases are fraught with a high rate of recurrence. We recently evaluated a patient who had undergone 6 surgical excisions of a postintubation laryngeal granuloma during a 5‐month interval. The larynx was treated with 1,200 cGy photon irradiation during a 4‐day period, and there has been no granuloma recurrence in 36 months of follow‐up. The rationale and selection criteria for patients who might benefit from low‐dose radiotherapy for recurrent laryngeal granulomas are discussed.
Malignant neuroendocrine tumor presenting in the mandible
Authors: Peters Edmund , Richards Allen , Hille Johannes , Phillips Jim 
Published: February 2007

AbstractThe carotid body, jugulotympanic, vagal, and laryngeal paragangliomas are the most common paragangliomas respectively within the head and neck, although unusual examples in other sites have been described. Among these are several references in the literature to a mandibular or “alveolar body” paraganglioma, even though such an entity does not appear to have been adequately documented. This report describes a case which presented as an extensive osteoblastic tumor involving the mandible and which radiographically appeared as a typical osteosarcoma. However, the immunohistochemical and electron microscopic features were of a neuroendocrine tumor and the histologic pattern suggested a paraganglioma. The tumor was nonfunctional and an extensive search failed to reveal any further lesions. Eight months after resection of the lesion, metastatic deposits appeared within the left iliac crest and lumbar vertebra. The origin of this tumor is discussed.
Labeling index in squamous cell carcinoma of the larynx
Authors: Balzi Manuela , Ninu Benedetta M. , Becciolini Aldo , Scubla Elena , Boanini Patrizia , Gallina Ezio , Gallo Oreste , Fini‐Storchi Omero , Bondi Roberto 
Published: February 2007

AbstractTwo cell kinetic parameters, the 3H‐thymidine labeling index (TLI) and the mitotic index (MI), were studied in vitro on fragments of squamous cell carcinoma tissue of the larynx. They were evaluated to identify those elements able to characterize the growth of these solid tumors. The values of these parameters were analyzed as a function of the clinical stage and the involvement of the regional lymph nodes. Results showed a statistically significant increase in the TLI from stage T1 to T3. No statistically significant differences in the TLI values were observed between the patients with positive and negative lymph nodes.
Temporal bone involvement by prostatic adenocarcinoma: Report of two cases and review of the literature
Authors: Sahin Aysegul A. , Ro Jae Y. , Ordonez Nelson G. , Luna Mario A. , Weber Randal S. , Ayala Alberto G. 
Published: February 2007

AbstractAlthough axial bone and cranial metastases are common in patients with prostatic carcinoma, temporal bone involvement is rare. We report 2 cases of prostatic adenocarcinoma with temporal bone metastasis and review the relevant literature. One case had a 3‐year history of a prostatic carcinoma, whereas in the second case the temporal bone metastasis was the initial presentation. Awareness of the possibility of temporal bone involvement by prostate carcinoma and application of immunohis‐tochemical studies will help to arrive at the correct diagnosis.
Lymphoma of the maxillary sinus in a patient infected with human immunodeficiency virus type 1
Authors: Goldstein Jeffrey , Rubin John , Becker Norwin , Moser Franklin , Silverstein Martin , Davis Lawrence 
Published: February 2007

AbstractA 27‐year‐old woman with a history of intravenous drug abuse presented with a stage IE, diffuse, large cell lymphoma of the right maxillary sinus. A test for antibodies to the human immunodeficiency virus was positive. The patient was treated with systemic chemotherapy and local maxillary sinus irradiation which resulted in complete regression of the disease. Therapy was complicated by mucositis, neutropenia, and opportunistic infections. This is the first case report to discuss the presentation and treatment of acquired immunodeficiency syndrome (AIDS)‐related lymphoma of the maxillary sinus.
Glottic cancer involving anterior commissure: Surgery vs radiotherapy
Authors: Rucci Lucio , Gallo Oreste , Fini‐Storchi Omero 
Published: February 2007

AbstractA retrospective review of 182 patients with glottic cancer involving the anterior commissure (AC) is presented. Of these, 123 patients were first treated with conservative surgery and 59 underwent radiotherapy. Patients were staged according to the AJCC system and by the modality of neoplastic involvement of AC (pure AC cancer, glottic cancer involving AC up to the midline, and beyond the midline). Our results indicate a higher rate of local control and of specific‐disease survival in the group of patients first treated with surgery than those treated with radiotherapy (86% vs 74% and 97.5% vs 84%, respectively) (p < 0.05). For pure AC cancers, our results show better local control with primary radiotherapy than with conservation surgery (82% vs 76.5%), but surgical failures have been more successfully salvaged than have radiotherapy recurrences (ultimate local control, 97.5% vs 82%, respectively). These data suggest that the treatment of choice for AC cancers is conservation surgery, particularly frontolateral laryngectomy.
Chemotherapy rapidly alternating with accelerated radiotherapy for advanced carcinomas of the hypopharynx and upper esophagus: A feasibility study
Authors: Vikram Bhadrasain , Malamud Stephen , Gold Jay , Nussbaum Moses , Kimmelman Charles , Lucente Frank , Pavlou William , Pisch Julianna , Chadha Manjeet , Beattie Edward 
Published: February 2007

AbstractPatients with advanced carcinomas of the hypopharynx or upper esophagus have among the worst prognoses in head and neck oncology. We developed a treatment regimen of rapidly alternating multi‐agent chemotherapy and accelerated interrupted radiotherapy as follows: Three cycles of chemotherapy were delivered [day 1, cisplatin 100 mg/m2; days 1‐4, 5‐fluorouracil (5‐Fu) 900 mg/m2] and repeated every 3 weeks. On day 8 of each chemotherapy cycle radiotherapy was started, consisting of 10 fractions of 200 cGy delivered twice daily, for 5 days. The total dose of radiotherapy was 6,000 cGy over 7 weeks, and the total duration of chemotherapy and radiotherapy was 8 weeks. Nineteen patients with locally advanced, epidermoid carcinoma of the hypopharynx (9 patients) or upper esophagus (10 patients) were treated on this protocol. Minimum follow‐up was 1 year. Twelve patients had tumors judged technically unresectable, whereas 7 had tumors considered resectable only with total laryngectomy, which was unacceptable to the patients. One patient died of nadir sepsis during treatment, but otherwise the acute toxicity was relatively mild (grade I/II in 16 patients, grade III/IV in 3 patients). The complete response rate was 83% (15 of 18 patients), and the partial response rate was 17% (3 of 18). No patient failed to respond. The survival rate was 80% at 1 year and 73% at 18 months. At 1 year, 89% of the patients remained in remission and at 18 months, 74%. Late complications occurred in 4 patients. These included laryngeal necrosis, pneumonitis, esophageal stricture, and tracheoesophageal fistula. Our experience suggests that this regimen is quite useful in cancers of the hypopharynx and upper esophagus and deserves further investigation.
Thyroid‐stimulating hormone levels after radiotherapy and combined therapy for head and neck cancer
Authors: Weissler Mark C. , Berry Billy W. 
Published: February 2007

AbstractSixty‐eight patients were studied prospectively with serial thyroid‐stimulating hormone (TSH) levels after radiotherapy for head and neck neoplasms. Overall, 57% of the patients developed elevated TSH levels. Excluding patients with less than 2 years follow‐up, 85% developed an elevated TSH. Ninety‐two percent of patients treated with partial thyroidectomy and radiotherapy developed an elevated TSH. Most TSH elevations occurred within 1 year of treatment. The dose of radiotherapy used and the performance of hemithyroidectomy were related to the development of elevated TSH levels (p < 0.05). The performance of radical neck dissection, gender, hyperfractionated radiotherapy, and the use of chemotherapy were not related to the development of an elevated TSH (p > 0.05).
Conservation surgery for inverted papillomas
Authors: Benninger Michael S. , Lavertu Pierre , Levine Howard , Tucker Harvey M. 
Published: February 2007

AbstractTo evaluate the role of conservation surgical treatment of inverted papillomas of the nose and paranasal sinuses, the clinical course of 46 patients treated during a 10‐year period was evaluated. Twelve patients were noted to have either invasive squamous cell carcinoma or carcinoma in situ and were excluded from analysis. Of the remaining 34 patients, 19 had previous treatment for inverted papilloma. Subsequently, 20 patients were treated with lateral rhinotomy and medial or partial maxillectomy. Fourteen patients were treated with conservation surgical therapy. There were 5 recurrences (15%), which all occurred in the conservation‐treated group. Four of six (66%) patients treated with an intranasal procedure recurred but only 1 of the 8 (12%) patients treated with a Caldwell‐Luc approach combined with an intranasal procedure. Successful treatment was achieved in all patients undergoing salvage surgery for recurrence. The role of conservation treatment in the management of inverted papillomas of the nose and paranasal sinuses is discussed.