bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lack of pathologic down‐staging with neoadjuvant chemotherapy for muscle‐invasive urothelial carcinoma of the bladder
Authors: Weight Christopher J. , Garcia Jorge A. , Hansel Donna E. , Fergany Amr F. , Campbell Steven C. , Gong Michael C. , Jones J. Stephen , Klein Eric A. , Dreicer Robert , Stephenson Andrew J. 
Published: February 2009

AbstractBACKGROUND:The postcystectomy survival benefit associated with the combination of methotrexate, vinblastine, doxorubicin, and cisplatin (MVAC) neoadjuvant chemotherapy (NC) for muscle‐invasive bladder cancer has been most evident in patients who achieve a pathologic complete response. The outcome of NC and open radical cystectomy (RC) was evaluated in a contemporary cohort of patients in a tertiary referral setting.METHODS:From January 2006 to November 2007, 117 patients underwent open RC at Cleveland Clinic for muscle‐invasive bladder cancer, 29 (25%) of whom received NC. Patient information was obtained from a prospective database.RESULTS:Clinical stage at the time of diagnosis in the NC cohort was T2 in 23 (79%) and T3‐4a in 6 (21%) patients. A total of 20 (69%) patients received the combination of gemcitabine and cisplatin (GC), 4 (14%) received MVAC, and 5 (17%) received other regimens. The median interval from the time of diagnosis of muscle‐invasive bladder cancer to RC was 208 days (interquartile range, 149 days ‐327 days) in the NC cohort. Overall, only 2 patients (7%; 95% confidence interval [95% CI], 0 patients‐17 patients) achieved a pathologic complete response, 18 (62%; 95% CI, 43 patients‐81 patients) had nonorgan‐confined residual cancer, and the overall median progression‐free survival was 10.5 months (95% CI, 7 months ‐14 months).CONCLUSIONS:Few RC patients in these investigators' recent experience achieved a pathologic complete response with NC, and most experienced rapid disease progression. These poor outcomes may be related to the use of non‐MVAC‐based regimens or excessive delay in performing RC. In the absence of supportive data for GC in the neoadjuvant setting, MVAC remained the preferred regimen. Excessive delays in performing RC may negate the benefit of NC. Cancer 2009. © 2009 American Cancer Society.
The Breast and Cervical Cancer Prevention and Treatment Act in Georgia
Authors: Adams E. Kathleen , Chien Li‐Nien , Florence Curtis S. , Raskind‐Hood Cheryl 
Published: February 2009

AbstractBACKGROUND:Implementation of the Breast and Cervical Cancer Prevention and Treatment Act of 2000 (BCCPTA) allowed states to extend Medicaid to any woman aged <65 without insurance screened and found to need treatment either for breast or cervical cancer or for a precancerous cervical condition through the National Breast and Cervical Cancer Early Detection Program (NBCCEDP) or in Georgia, other provider sites.METHODS:The authors used linked Georgia Comprehensive Cancer Registry (GCCR) and Medicaid data to test the: 1) likelihood of Medicaid enrollment in a given month and 2) time‐to‐enrollment (months) for those eventually enrolling. The authors used difference‐in‐differences analysis to estimate the effects of BCCPTA for breast or cervical cancer cases relative to a control group of women with other cancers. The authors controlled for sociodemographics, stage at diagnosis, year of diagnosis, and county level factors related to insurance levels in the area.RESULTS:Compared with the control cancer group, the hazard ratio of Medicaid enrollment for women with breast and cervical cancers increased post‐ vs pre‐BCCPTA implementation. The estimated effect of this increase was that out of every 1000 women with breast cancer, BCCPTA led to 1.7 more (from 2.8 to 4.5 per month) enrolling in Medicaid. The results for women with local or later stages of cervical cancer indicated that of 1000 women with these cancers, the number enrolling in a given month increased by 3.4 due to BCCPTA. Results on time‐to‐enrollment indicated that the time between cancer diagnosis and enrollment was shortened by 7 to 8 months.CONCLUSIONS:The Georgia Medicaid program, in response to national legislation, increased the probability of women enrolling in Medicaid earlier and in turn, likely increased their cancer treatment options. Cancer 2009. © 2009 American Cancer Society.
Role of surgical outcome as prognostic factor in advanced epithelial ovarian cancer: A combined exploratory analysis of 3 prospectively randomized phase 3 multicenter trials
Authors: du Bois Andreas , Reuss Alexander , Pujade‐Lauraine Eric , Harter Philipp , Ray‐Coquard Isabelle , Pfisterer Jacobus 
Published: February 2009

AbstractBACKGROUND:Primary surgery followed by platinum‐taxane based chemotherapy has been the standard therapy in advanced ovarian cancer. However, the prognostic role of complete and so‐called optimal and suboptimal debulking and its interaction with biological factors has not been not fully defined.METHODS:Exploratory analysis was conducted of 3 prospective randomized trials (AGO‐OVAR 3, 5, and 7) investigating platinum‐taxane based chemotherapy regimens in advanced ovarian cancer conducted between 1995 and 2002.RESULTS:A total of 3126 patients were analyzed. Approximately one‐third each fulfilled criteria for complete resection (group A), small residual tumor burden of 1‐10 mm (group B), or macroscopic residual disease exceeding 1 cm in diameter (group C). Multivariate analysis showed improved progression‐free and overall survival for group A with complete resection compared with groups B or C (P < .0001). The impact of so‐called optimal debulking as in group B showed a smaller prognostic impact compared with group C. Further independent prognostic factors for overall survival were age, performance status, grade, FIGO stage, and histology, namely the mucinous subtype. An interaction between residual tumor and some biologic factors was demonstrated.CONCLUSIONS:The goal of primary surgery should be complete resection. The prognostic impact of tumor biology seemed to be partially overruled by residual tumor and further evaluation of biologic factors should stratify for residual tumor. Cancer 2009. © 2009 American Cancer Society.
Conflicting Observations Resolved by a Far IR and UV/Vis Study of the NO3 Radical
Authors: Beckers Helmut , Willner Helge , Jacox Marilyn E. 
Published: February 2009

AbstractCodeposition of NO and O2 diluted in Ne at 6 K yield a ON⋅⋅⋅OO complex that exhibit strong UV absorption. This complex is converted into NO3 radicals by UV irradiation, and is regenerated by radiation of visible light (see spectra).magnified imageBy codeposition of NO/Ne and O2/Ne mixtures at 6 K, weakly bound complexes between O2 and NO are formed. They exhibit a strong, structured charge transfer UV band at λmax=275 nm. The UV band disappears during UV irradiation of the neon matrix, while the visible spectrum of the NO3 radical appears. Simultaneously, the fundamental ν4 of the NO3 radical in the ${\mathop X\limits^\sim }$ 2A2′ ground state is observed in infrared absorption for the first time at 365.6 cm−1. Its 14/15N and 16/18O isotopic shifts reveal strong couplings between the two e′‐type modes of NO3, which are both active in a pseudo‐Jahn–Teller interaction with the excited ${\mathop B\limits^\sim }$ 2E′ electronic state. The dispute on the vibrational fundamentals of the NO3 radical is now concluded by the unambiguous assignment of combination bands associated with the fundamental ν4. Taking into account the observed isotopic shifts and estimated anharmonicities for ν4 and the most intense IR band of NO3 at 1492 cm−1 (ν3+ν4), the frequency of the so far not observed fundamental ν3 is estimated to be 1100±10 cm−1. A tentative assignment of the vibronic levels in the IR spectrum in the range from 1000 to 3000 cm−1 is given.
Spontaneous High‐Yield Production of Hydrogen from Cellulosic Materials and Water Catalyzed by Enzyme Cocktails
Authors: Ye Xinhao , Wang Yiran , Hopkins Robert C. , Adams Michael W. W. , Evans Barbara R. , Mielenz Jonathan R. , Zhang Y.‐H. Percival 
Published: February 2009

AbstractCocktail reception: Biohydrogen is produced in high yield from cellulosic materials and water in a one‐pot process catalyzed by up to 14 enzymes and one coenzyme. This assembly of enzymes results in non‐natural catabolic pathways. These spontaneous reactions are conducted under modest reaction conditions (32 °C and atmospheric pressure).magnified image
Regelungen der ETB‐Richtlinie zur Begrenzung der Formaldehydemission in die Raumluft bei Verwendung von Harnstoff‐Formaldehydharz‐Ortschaum (ETB‐Ri UF‐Ortschaum)
Authors: Fechner Otto 
Published: February 2009

AbstractImmer mehr Besitzer von Gebäuden mit zweischaligem Mauerwerk entscheiden sich aus energetischen Gesichtspunkten für die nachträgliche Wärmedämmung der Hohlschicht im Mauerwerk. In letzter Zeit sind vermehrt Anfragen an das DIBt gerichtet worden, die darauf hindeuten, dass es nach solchen Dämmmaßnahmen in Gebäuden zu länger anhaltenden erhöhten Formaldehydbelastungen gekommen ist. Wir nehmen dies zum Anlass, auf die Regelungen der ETB‐Ri UF‐Ortschaum sowie der in diesem Bereich erteilten Zulassungen hinsichtlich der Bestimmungen für die Verwendung hinzuweisen.Das Deutsche Institut für Bautechnik (DIBt) erteilt etwa seit Anfang der 80er Jahre für die Herstellung und Verwendung von nachträglich in Hohlschichten von zweischaligem Mauerwerk für Außenwände eingeschäumte UF‐Ortschäume (Kerndämmung) allgemeine bauaufsichtliche Zulassungen. Nachfolgend sind die Voraussetzungen zur Beschränkung der Abgabe von Formaldehyd, die von Herstellern und Verarbeitern zu beachten sind, zusammengestellt.
Aktuelle europäische Rechtsänderungen
Authors: Abend Kerstin 
Published: February 2009

AbstractIm Heft 6 der DIBt Mitteilungen ist in einem kurzen Überblick über aktuelle europäische Rechtsentwicklungen, einschließlich des Kommissionsvorschlags für eine europäische Bauprodukteverordnung sowie einer Stellungnahme des Bundesrats vom 19. September 2008 (Drucksache 400/08 (Beschluss)) zu diesem Vorschlag, berichtet worden.Der Entwurf für eine Bauprodukteverordnung (BauPVO‐E) wird weiterhin auf europäischer Ebene unter den Mitgliedstaaten in einer sog. Rats‐Arbeitsgruppe (unter Leitung des Mitgliedstaats, der die Ratspräsidentschaft der Europäischen Union innehat, diese obliegt im ersten Halbjahr 2009 Tschechien) sowie parallel im Europäischen Parlament beraten. Aufgrund der fortgesetzten Diskussionen hat der Bundesrat einen zweiten Beschluss zum Kommissionsvorschlag gefasst. In diesem Beschluss vom 28.11.2008 (Drucksache 400/08 (Beschluss) (2)) wird die Bundesregierung gebeten, bei den Verhandlungen auf europäischer Ebene auf bestimmte Änderungen zum Verfahren der Europäischen Technischen Bewertung sowie zu den Bestimmungen der Marktüberwachung hinzuwirken. Der Beschluss ist nachfolgend abgedruckt.
Zulassungsverfahren für Laminatbodenbeläge nach DIN EN 14041
Authors: Eichler Antje 
Published: February 2009

Abstract1. Hintergründe/Historie zum Zulassungsverfahren für Laminatbodenbeläge2. DIBt/EPLF/WKI‐Projekt zur Erarbeitung von Kriterien zur Vereinfachung des Zulassungsverfahrens für Laminatbodenbeläge3. Vorstellung der Ergebnisse des Projektes im Rahmen der DIBt‐Informationsveranstaltung “Zulassungsverfahren für Laminatbodenbeläge nach DIN EN 14041” – Erfahrungstransfer, Berichte und Informationen zum Stand und zu Änderungen im Zulassungsverfahren
“Rettung von Personen” und “wirksame Löscharbeiten” – bauordnungsrechtliche Schutzziele mit Blick auf die Entrauchung
Authors: Famers Gabriele , Messerer Joseph 
Published: February 2009

AbstractIm Zusammenhang mit der Erstellung von Brandschutzkonzepten für komplexe Bauaufgaben stellt sich häufig die Frage nach den mit den bauordnungsrechtlichen Vorschriften verfolgten Schutzzielen. Diskussionen in der Fachwelt haben gezeigt, dass über diese Ziele in einigen Punkten Unklarheit besteht. Zudem war zu beobachten, dass sich die Auffassungen darüber, was öffentlich‐rechtlich erforderlich ist, aus unterschiedlichen Gründen auseinander entwickelt haben, wie z. B. hinsichtlich der Notwendigkeit einer raucharmen Schicht für die Personenrettung, aber auch über die Frage, was unter “wirksamen” Löschmaßnahmen zu verstehen ist.Die Fachkommission Bauaufsicht der Bauministerkonferenz – ARGEBAU, die für die Musterbauordnung (MBO) als Muster für die Landesbauordnungen zuständig ist, hat sich dieser Frage angenommen und ihre Projektgruppe Brandschutz mit diesbezüglichen Untersuchungen beauftragt. Dabei wurden alle Regelungen der Musterbauordnung und der zugehörigen Sonderbauvorschriften auf ihre Zielsetzung hinterfragt. Das Ergebnis sind die nachfolgend abgedruckten Grundsätze zu Fragen der Personenrettung und wirksamen Löschmaßnahmen.
Caffeine, artificial sweetener, and fluid intake in anorexia nervosa
Authors: Marino Joanna M. , Ertelt Troy E. , Wonderlich Stephen A. , Crosby Ross D. , Lancaster Kathy , Mitchell James E. , Fischer Sarah , Doyle Peter , Le Grange Daniel , Peterson Carol B. , Crow Scott 
Published: February 2009

AbstractObjectiveThis article provides an analysis of the use of artificial sweeteners, caffeine, and excess fluids in patients diagnosed with anorexia nervosa (AN).MethodSeventy participants with AN were recruited to participate in an ecologic momentary assessment study which included nutritional analysis using the Nutrition Data Systems for Research, a computer based dietary recall system.ResultsWhen subtypes were compared, participants with AN‐restricting subtype (AN‐R) and participants with AN‐Binge‐Purge (AN‐B/P) did not differ in quantity of aspartame, caffeine, or water consumed. Daily water consumption was related to daily vomiting frequency in AN‐B/P but not to daily exercise frequency in either participants with AN‐R or AN‐B/P.DiscussionCaffeine, water, and aspartame consumption can be variable in patients with AN and the consumption of these substances seems to be only modestly related to purging behavior. © 2009 by Wiley Periodicals, Inc. Int J Eat Disord 2009
Second‐degree atrioventricular block (Mobitz Type I) in an adolescent with anorexia nervosa: Intrinsic or acquired conduction abnormality
Authors: Kanbur Nuray Ö. , Goldberg Eudice , Pinhas Leora , Hamilton Robert M. , Clegg Robin , Katzman Debra K. 
Published: February 2009

AbstractAnorexia nervosa (AN) can cause both functional and structural cardiac complications, including a variety of different conduction abnormalities. This is the first case report of symptomatic diurnal second‐degree atrioventricular (AV) block (Mobitz Type I) in an adolescent with AN. We present a 12‐year‐old girl with AN, restrictor sub‐type who reported cardiac symptoms during weight gain, at the time of the initial diagnosis of AV block. Second‐degree AV block (Mobitz Type I) is discussed as a possible complication of the AN, as well as being an intrinsic conduction system disease. © 2009 by Wiley Periodicals, Inc. Int J Eat Disord 2009
Family functioning and maternal distress in adolescent girls with anorexia nervosa
Authors: Sim Leslie A. , Homme Jason H. , Lteif Aida N. , Vande Voort Jennifer L. , Schak Kathryn M. , Ellingson Jarrod 
Published: February 2009

AbstractObjectiveTo determine the nature of family distress in families of girls with anorexia nervosa (AN), this study compared aspects of family functioning in adolescent girls with AN to girls with a chronic illness and girls without a condition.MethodParticipants consisted of 25 adolescent girls with a primary DSM‐IV diagnosis of AN, 20 girls with an ICD‐10 diagnosis of insulin dependent diabetes mellitus (IDDM), and 20 girls from the community. Mothers and daughters completed questionnaires of family functioning and psychological symptoms.ResultsWhen compared with mothers of daughters with IDDM, families of girls with AN experienced greater family conflict, reduced parental alliance, and increased feelings of depression. However, once the emotional impact of the illness on the mothers was statistically controlled, group differences were no longer significant.DiscussionFamily distress and dysfunction may reflect an accommodation process that occurs in families living with a child with AN. © 2009 by Wiley Periodicals, Inc. Int J Eat Disord 2009
The CDK domain of p21 is a suppressor of IL‐1β‐mediated inflammation in activated macrophages
Authors: Scatizzi John C. , Mavers Melissa , Hutcheson Jack , Young Brittany , Shi Bo , Pope Richard M. , Ruderman Eric M. , Samways Damien S. K. , Corbett John A. , Egan Terrance M. , Perlman Harris 
Published: February 2009

AbstractSignificant morbidity and mortality can be attributed to inflammatory diseases; therefore, a greater understanding of the mechanisms involved in the progression of inflammation is crucial. Here, we demonstrate that p21(WAF1/CIP1), an established suppressor of cell cycle progression, is a inhibitor of IL‐1β synthesis in macrophages. Mice deficient in p21 (p21−/−) display increased susceptibility to endotoxic shock, which is associated with increased serum levels of IL‐1β. Administration of IL‐1 receptor antagonist reduces LPS‐induced lethality in p21−/− mice. Analysis of isolated macrophages, which are one of the central producers of IL‐1β, reveals that deficiency for p21 led to more IL‐1β mRNA and pro‐protein synthesis following TLR ligation. The increase in IL‐1β pro‐protein is associated with elevated secretion of active IL‐1β by p21−/− macrophages. siRNA‐mediated knockdown of p21 in human macrophages results in increased IL‐1β secretion as well. A peptide mapping strategy shows that the cyclin‐dependent‐kinase (CDK)‐binding domain of p21 is sufficient to reduce the secretion of IL‐1β by p21−/− macrophages. These data suggest a novel role for p21 and specifically for the CDK‐binding domain of p21(WAF1/CIP1) in inhibiting inflammation.
CTL induction by cross‐priming is restricted to immunodominant epitopes
Authors: Pavelic Viktor , Matter Matthias S. , Mumprecht Sabine , Breyer Isabel , Ochsenbein Adrian F. 
Published: February 2009

AbstractCTL are induced by two pathways, i.e. direct priming, where tumor cells present tumor antigens to naïve specific CTL, and cross‐priming, where professional APC cross‐present captured tumor antigens to CTL. Here, we examined direct priming versus cross‐priming after immunizing (H‐2b×H‐2d) F1 mice with either H‐2b or H‐2d positive tumor cells transfected with the GP or nucleoprotein (NP) of lymphocytic choriomeningitis virus (LCMV). Cross‐priming was observed for the immunodominant epitopes LCMV‐gp33 and ‐np118, although direct induction resulted in higher CTL frequencies. In contrast, CTL specific for the subdominant epitopes LCMV‐gp283 or ‐np396 were induced only if epitopes were presented directly on MHC class I molecules of the immunizing cell. The broader repertoire and the higher CTL frequencies induced after vaccination with haplotype‐matched tumor cells resulted in more efficient anti‐tumor and antiviral protection. Firstly, our results indicate that certain virus and tumor antigens may not be detected by CD8+ T cells because of impaired cross‐priming. Secondly, efficient cross‐priming contributes to the immunodominant nature of a tumor‐specific CTL epitope. Thirdly, vaccine strategies using autologous or syngenic antigen‐expressing cells induce a broader repertoire of tumor‐specific CTL and higher CTL frequencies.
Solid‐State and Solution Structure of Lanthanide(III) Complexes with a Flexible Py‐N6 Macrocyclic Ligand
Authors: Núñez Cristina , Mato‐Iglesias Marta , Bastida Rufina , Macías Alejandro , Pérez‐Lourido Paulo , Platas‐Iglesias Carlos , Valencia Laura 
Published: February 2009

AbstractLanthanide complexes of a hexaaza macrocyclic ligand containing a pyridine head unit (L) were synthesized (Ln = La–Lu, except Pm). The solid‐state structures of the corresponding La, Ce, Pr, Nd, and Lu complexes were determined by single‐crystal X‐ray crystallography, and they reveal the presence of three different mononuclear complexes with three different conformations of the macrocycle and coordination environments around the metal ions. In all complexes the lanthanide ion is coordinated in an endomacrocyclic manner to the six nitrogen donor atoms of the ligand. In the La, Ce, and Pr complexes the metal ions show a 12‐coordinate mononuclear environment in which 3 nitrate anions coordinate in a bidentate fashion. However, in the Nd analogue the metal ion displays a 10‐coordinated environment with the coordination of 2 bidentate nitrate groups, whereas Lu shows a 9‐coordinate environment interacting with 2 nitrate ligands, one of them acting as bidentate and the second one coordinating in a monodentate fashion. The 1H and 13C NMR spectra of the complexes recorded in CD3CN suggest that the complexes adopt in solution a similar structure to that observed for the Nd complex in the solid state. The [Ln(L)(NO3)3] and [Ln(L)(NO3)2]+ complexes were characterized by density functional theory (DFT) calculations (B3LYP model). The structures obtained from these calculations for La, Ce, Pr, and Nd are in good agreement with the experimental solid‐state structures. The relative stabilities of the [Ln(L)(NO3)2]+ complexes with respect to the [Ln(L)(NO3)3] ones (Ln = La, Nd, Gd, Ho, or Lu) were studied both in vacuo and in acetonitrile solution (PCM model) at the same computational level. Our calculations indicate that in solution the [Ln(L)(NO3)2]+ species is the most stable one along the whole lanthanide series, in agreement with the NMR spectroscopic data.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Bifunctional Binols: Chiral 3,3′‐Bis(aminomethyl)‐1,1′‐bi‐2‐naphthols (Binolams) in Asymmetric Catalysis
Authors: Nájera Carmen , Sansano José M. , Saá José M. 
Published: February 2009

Abstract3,3′‐Bis(dialkylaminomethyl)‐1,1′‐binaphth‐2‐ols (Binolams) have emerged during the last five years as very efficient chiral ligands in many enantioselective processes. Enantiomerically pure Binolams are easily accessible by means of a variety of methods, the most widely used being the so‐called chiral Binol route. In most cases, Binolam‐metal complexes behave as bifunctional catalysts: that is, they are characterized by their dual action on the reagents, being able to activate both the nucleophilic and the electrophilic species involved in the reaction. The most successful transformations carried out with complexes of this type include cyanation of aldehydes and ketones and enantioselective nucleophilic additions of enolate derivatives and organometallic compounds to C=O or C=N double bonds. As a final bonus, the basic natures of these ligands allow their recovery in high yields in numerous transformations. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Synthesis of Rigid π‐Conjugated Mono‐, Bis‐, Tris‐, and Tetrakis(terpyridine)s: Influence of the Degree and Pattern of Substitution on the Photophysical Properties (Eur. J. Org. Chem. 6/2009)
Authors: Winter Andreas , Friebe Christian , Hager Martin D. , Schubert Ulrich S. 
Published: February 2009

AbstractThe cover picture shows the bright photoluminescence properties of oligo(terpyridine) derivatives in dilute solution and in thin solid films. The photophysical properties of the materials depend on the number of π‐conjugated terpyridine moieties attached to the central phenyl core as well as on the substitution pattern. Details are discussed in the article by U. S. Schubert et al. on p. 801 ff.