bluuebunny/crossref_metadata_2025_split huggingface dataset:
A post‐marketing safety and efficacy assessment of a monoclonal antibody purified high‐purity factor VIII concentrate
Authors: HAY C. R. M. , LEE C. A. , SAVIDGE G. 
Published: June 2007

Summary. The identification of infrequent side‐effects of clotting factor concentrates, undetected by clinical trials, is facilitated by post‐marketing surveillance. We present a post‐marketing surveillance study in which 97 patients with haemophilia A, attending three haemophilia centres, were treated over a median follow‐up period of 284 days (range 1–1074), and a total follow‐up period of 30,080 days, with a pasteurized immunoaffinity purified factor VIII concentrate (Monoclate‐P, Armour, Collegeville, USA). 5216 infusions, using 10,527,000 units of Monoclate‐P, were carried out, mostly for routine haemarthroses or prophylaxis.No new inhibitors were observed during the study. At the start of the study 60/97 were HIV seropositive, 67/97 HBs antibody positive, 12 HbsAb negative and the remainder HBsAb positive before the study period. 13/14 tested were HAV seropositive at the beginning of the study. One patient became HAV seropositive during the study period, an infection thought to be community acquired. No other seroconversions were observed. Only one mild transfusion reaction was observed. This study confirms the safety and efficacy of Monoclate‐P. Post‐marketing surveillance or nationally organized pharmaco‐vigilance should be practiced more widely to enable identification of low‐frequency side‐effects of treatment.
Hepatitis B serology and DNA detection in multitransfused haemophiliacs and factor VIII and IX concentrates
Authors: WATSON H. G. , LUDLAM C. A. , REBUS S. , PEUTHERER J. F. , SIMMONDS P. 
Published: June 2007

Summary. To assess the effect of HIV infection and the introduction of virus‐inactivated concentrates, we conducted a retrospective 20‐year longitudinal study of hepatitis B virus (HBV) serology and look for HBV DNA in recent serum samples of 63 multiply transfused haemophiliacs.Of 63 haemophiliacs, 51 had evidence of previous HBV infection and 12 vaccinees had anti‐HBs only. Of 40 HIV‐negative, two had persistent HBsAg but all were HBV DNA negative. All 23 HIV‐positive were HBsAg‐negative. Loss of anti‐HBc(46% vs. 17.5%) and anti‐HBs (32% vs. 14%) was more commonly seen in HIV‐infected compared with noninfected individuals. One HIV‐positive individual had HBV DNA detectable by PCR. Restrospective testing demonstrated that re‐emergence was associated with loss of anti‐HBs and advanced HIV infection (CD4<50 × 106–1L CDC II), although eight other with CDC IV disease were HBV DNA negative.Forty‐three batches of concentrates produced between 1965 and 1992 from both commercial and volunteer donors and subjected to different donor screening and virus inactivation methods were negative for HBV DNA. Some of these may have been infectious for HBV and therefore being negative for HBV may not equate with noninfectivity.We conclude that both HIV‐positive and ‐negative haemophiliacs have lost protective antibodies against HBV since 1984 and that virus replication may re‐emerge at least in the HIV‐positive group. These observations may have implications for the management of their chronic liver disease and the risk of infection of sexual partners and medical attendants.
Alignment of multiple chromosomes along helical ParA scaffolding in sporulating Streptomyces hyphae
Authors: Jakimowicz Dagmara , Żydek Paulina , Kois Agnieszka , Zakrzewska‐Czerwińska Jolanta , Chater Keith F. 
Published: June 2007

SummaryThe dynamic, mitosis‐like segregation of bacterial chromosomes and plasmids often involves proteins of the ParA (ATPase) and ParB (DNA‐binding protein) families. The conversion of multigenomic aerial hyphae of the mycelial organism Streptomyces coelicolor into chains of unigenomic spores requires the synchronous segregation of multiple chromosomes, providing an unusual context for chromosome segregation. Correct spatial organization of the oriC‐proximal region prior to septum formation is achieved by the assembly of ParB into segregation complexes (Jakimowicz et al., 2005; J Bacteriol 187: 3572–3580). Here, we focus on the contribution of ParA to sporulation‐associated chromosome segregation. Elimination of ParA strongly affects not only chromosome segregation but also septation. In wild type hyphae about to undergo sporulation, immunostained ParA was observed as a stretched double‐helical filament, which accompanies the formation of ParB foci. We show that ParA mediates efficient assembly of ParB complexes in vivo and in vitro, and that ATP binding is crucial for ParA dimerization and interaction with ParB but not for ParA localization in vivo. We suggest that S. coelicolor ParA provides scaffolding for proper distribution of ParB complexes and consequently controls synchronized segregation of several dozens of chromosomes, possibly mediating a segregation and septation checkpoint.
Quiste epidermoide ciliado en el timo cervical de un cerdo (Sus scrofa domesticus) su significación
Authors: Postiglioni‐Grimaldi J. 
Published: June 2007

ResumenEl autor describe un caso de quiste epidermoide ciliado en el timo cervical de un cerdo, considerándolo como derivado del epiblasto, probablemente, del seno cervical del embrión.ZusammenfassungEine Epidermoidzyste mit Borstenbesatz im Halsthymus eines Schweines (Sus scrofa domesticus) und ihre BedeutungEine Epidermoidzyste mit 2 Borsten wird abgebildet, die im Halsthymus eines Schweines gefunden wurde. Die Zyste ist als Derivat des Epiblasten an‐zusehen und entstammt wahrscheinlich dem Sinus cervicalis.
Endocardial Surfaces in Man
Authors: Tucker Richard 
Published: June 2007

SummaryThe endocardial surfaces were studied by means of the scanning electron microscope. The subendocardial muscle bundles in the heart were separated by deep and spacious grooves. The division of muscle fibres frequently occurs in an X‐figure. The central portion of the figure is always elevated, although its length may vary in different fibres. The striae on the muscular fibres have also been described. Functional significance of the above findings was discussed.
The Foramina of the Cervical Vertebrae of the Ox
Authors: Smuts M. M. S. 
Published: June 2007

SummaryAll the macroscopically visible foramina of the atlas and axis in 20 oxen are examined and their size, incidence and connections described. The atlas possesses a canal connecting the atlantal fossa with the vertebral foramen. It is suggested that it be named “Canalis vertebroalaris”. The axis contains a prominent transverse canal rather than a foramen, with “cranial” and “caudal transverse foramina”. The canal occurs in an atypical location in 25 % of cases.
Die 3 Gleitdruckkörper des M. masseter des Meerschweinchens
Authors: Stede M. , Preuss F. 
Published: June 2007

ZusammenfassungDie 3 Gleitdruckkörper des M. masseter des MeerscfaweinchensDie 3 Gleitdruckkörper in verschiedenen Portionen des M. masseter des Meerschweinchens werden makro‐ und mikroanatomisch dargestellt. Besonderer Wert wird auf die Schilderung und Diskussion der Histologic und der Bedeutung eines Cubiculus genannten Kammerfeldes gelegt, das sich häufig an der Stelle einer sonst unter den Sesamkörpern befindlichen Bursa synovialis befindet. Der Cubiculus entsteht durch die Umwandlung des lockeren Bindegewebes in Lamellen, die Synovialiszellen enthalten, welche eine interlamelläre Synovia liefern. Deshalb wird ihm der Wert einer Bursavorstufe zuerkannt. Fälle, in denen er den Wert einer Rückbildungsstufe eines Gelenkes besitzt, werden erwähnt. Ferner wird angeregt, zwischen Gleitsehnen, Zugsehnen und Drucksehnen zu unterscheiden.
The Arteria maxillaris of the Camel (Camelus dromedarius)
Authors: Badawi Helmi , El‐Shaieb Mohamed , Kenawy Ahmed 
Published: June 2007

SummaryThe origin, course, and distribution of the maxillary artery and its branches in the camel (Camelus dromedarius) were described in detail. Comparative anatomical differences of interest have been given whenever found beneficial.ZusammenfassungDie A. maxillaris des Kamels (Camelus dromedarius)Ursprung, Verlauf und Aufzweigung der A. maxillaris und ihrer Äste werden beim Kamel detailliert beschrieben. Auf vergleichend‐anatomische Unterschiede wird jeweils hingewiesen.RésuméĽArtère maxillaire du Chameau (Camelus dromedarius)On donne la description détaillée de ľorigine, du trajet et de la distribution de ľ artère maxillaire (A. maxillaris) et de ses rameaux, chez le chameau. Chagne point est envisagé sous ľangle des différences, ďun point de vue comparatif.ResumenLa Arteria maxilar del camello (Camelus dromedarius)En el camello, se describen detalladamente el origen, el trayecto y las ramificaciones de la A. maxillaris y sus ramas, destacándose las diferencias de su anatomía comparada.
Effect of Mitomycin C on the Chondrogenic Morphology in the Hind‐Limb of Chick Embryos
Authors: Sinha D. N. , Singh Shamer 
Published: June 2007

SummaryMitomycin C was injected on the 5th day of incubation into the yolk sac of White leghorn chicken eggs. The hind‐limbs were dissected and measured on 6th, 7th, 8th and 9th days of incubation. A statistically significant suppression of growth in treated limbs (P < 0.05) was observed from 6th through 9th day of incubation. Histological observations clearly demonstrated the suppressive and damaging effect of mitomycin C on the morphology of chondrogenic tissue, i. e., on the perichndrium and the differentiating cartilage cells. These changes were evident within 24 hours of the treatment and posibly cause the limb defects (described elsewhere) induced by this drug.ZusammenfassungEinfluß von Mitomycin C auf die Chondrogenese der Beckengliedmaße von HühnerembryonenMitomycin C wurde am 5. Bebrütungstag in den Dottersack von Eiern der Weißen Leghorn‐Rasse injiziert. Die Beckengliedmaßen wurden am 6., 7., 8. und 9. Tag abgetrennt und gemessen. Vom 6.‐9. Tag war eine signifi‐kante (P< 0,05) Wachstumsverzögerung feststellbar, wobei der Verzöge‐rungs‐ und SchädigungserTekt eindeutig das chondrogene Gewebe (Perichondrium und sich differenzierende Knorpelzellen) betrifft. Diese Veränderungen scheinen innerhalb von 24 Stunden nach der Injektion auf und verursachen wahrscheinlich jene Gliedmaßenschädigungen, wie sie von diesem Chemotherapeutikum induziert werden.RésuméInfluence de la Mitomycine C sur la chondrogénèse des membres pelviens de ľembryon de PouletOn a procédèà. des injections de Mitomycine C dans la vésicule vitelline ďceuf de Leghorn blanche, au 5e hour ďincubation. Les membres pelviens out été prélevés et mesurés aux 6e, 7e, 8e et 9e jours ďincubation. Du 6e au 9e jour, on a observé un retard de croissance significatif (P < 0.05) pour les membres des sujets ainsi trails. Les observations histologiques ont clairement demontréľeffet répressif et nocif de la mitomycine C sur le tissu chondrogène, en particulier sur le périchondre et sur les cellules cartilagineuses en voie de différenciation. Ces altérations se sont révélées évidentes dans les 24 heures après ľinjection et semblent être la cause possible des malformations des membres provoquées par ce médicament et qui ont été décrites par ailleurs.ResumenLa influencia de Mitomicina C sobre el desarrollo de los cartílagos en los miembros inferiores de embriones del polioSe inyectó Mitomicina C en el saco vitelino de huevos de polios Leghorn blancos el 5° día de incubación y en los días 6, 7, 8 y 9 se cortaron y se midieron los miembros inferiores. Entre los días6–9, se observó una supresión significativa (P < 0,05) del crecimiento. Estudios histológicos demostraron la influencia nociva de la Mitomicina C sobre los tejidos condrógenos (pericondrio y células cartilaginosas en diferenciación). Estos cambios aparecieron 24 horas después de la inyección causando los mencionados defectos de los miembros.
A Quantitative Evaluation of Placentome Development in Zebu Cattle (Bos indicus)
Authors: Stickland N. C. , Purton M. D. 
Published: June 2007

SummaryQuantitative changes occurring during placentome development were studied in detail in fetuses of local Zebu cattle ranging in age from about 75 to 245 days of gestation. Total placentome cross‐sectional area increased continuously throughout gestation, although placentome number remained constant; this was brought about by an increase in mean placentome crosssectional area alone. Mean placentome cross‐sectional area in the gravid horn was almost twice as great as that in the non‐gravid horn at all stages of gestation. Changes in placentome cross‐sectional area were closely related to changes in placentome depth and volume.ZusammenfassungQuantitative Erhebungen zur Plazentomentwicklung beim Zebu(Bos indicus)Die quantitativen Veränderungen der Plazentomentwicklung wurden an Zebu‐Föten im Trächtigkeitsalter von 75–245 Tagen studiert. Bei gleichbleibender Anzahl der Plazentome nimmt deren Gesamtquerschnittsfläche während der Trächtigkeit ständig zu, und zwar als Folge der Zunahme der mittleren Flächengröße der einzelnen Plazentome, die durchweg im trächtigen Horn fast doppelt so groß war wie im nichtträchtigen. Diese Änderungen hängen mit Änderungen der Höhe und des Umfanges der Plazentome eng zusammen.RésuméEvaluation quantitative du développement des placentomes chez le zébu(Bos indicus)Les changements quantitatifs qui se produisent pendant le développement des placentomes ont étéétudiés chez des fœtus de Zébu de race locale âgés de 75 à 245 jours de gestation. La surface totale des placentomes en coupe transversale augmente de façon continue pendant toute la gestation, bien que le nombre de placentomes reste constant. Ceci est réalisé par la seule augmentation de la surface moyenne de section des placentomes. Cette moyenne s'est avérEé presque deux fois plus grande dans la corne gravide que dans la corne non gravide à tous les stades de la gestation. Les changements ont été lié s à ceux du volume des placentomes.ResumenUna evaluación cuantitativa del desarrollo de los placentomas del cebú(Bos indicus)Los cambios cuantitativos durante el desarrollo de los placentomas se estudiaron en fetos del cebú de aproximadamente 75 a 245 días de edad. Durante la gestación, la superficie total de cortes transversos de los placentomas aumenta constantemente, manteniétidose su número igual; esto se debe sólo al aumento de superficie cuyo promedio es casi el doble en el cuerno gravido en comparación con el otro. Estos cambios están intimamente relacionados con los cambios de los placentomas en altura y volumen.
A Study on Lig. nuchae of the One‐humped Camel (Camelus dromedarius)
Authors: Mobarak A. M. , Fouad S. M. 
Published: June 2007

SummaryThe parts, attachment and structure of the Lig. nuchae are described and illustrated. In the camel, Lig. nuchae is greatly similar to that of the horse but much different from the same of the ox. Synovial bursae are absent.ZusammenfassungDas Lig. nuchae des einhöckerigen Kamels (Camelus dromedarius)Teile, Befestigung und Aufbau des Nackenbandes vom Kamel werden beschrieben. Es entspricht weitgehend dem des Pferdes, aber unterscheidet sich sehr von dem des Rindes. Schleimbeutel fehlen.
Feinstruktur des Bulbus olfactorius der Hauswiederkauer1,2
Authors: Löchelt F. , Goller H. , SCHNORR B. 
Published: June 2007

ZusammenfassungDie feinstrukturellen Untersuchungen des Bulbus olfactorius von Rind, Schaf und Ziege ergeben, daß bei alien 3 Tierarten der charakteristische Aufbau aus adit voneinander leidit unterscheidbarer Sdiiditen sehr ahnlidi ist und audi zu den übrigen Säugern weitgehende Obereinstimmung besteht. Tierartlidie Untersdiiede sind lediglidi in der Didte der einzelnen Sdiiditen und in der Größe und Anordnung der Zellen und Fasern zu beobaditen. Audi der Bulbus olfactorius accessorius laßt nadi der Lage und Entfaltung nur geringe Untersdiiede zwisdien Rind und kleinen Wiederkauern erkennen.SummaryFine structure of the olfactory bulb of the domestic ruminantsElectronmicroscopical examinations in ox, sheep and goat revealed that in all three species the olfactory bulb consisted of eight easily distinguishable layers, and that its structure was similar to that of the olfactory bulb of other mammals. Species differences were seen only in the thickness of the various layers and in the size and topography of the cells and fibers. There are only slight differences in position and development of the accessory olfactory bulb between ox and small ruminants.RésuméStructure fine du Bulbus olfactorius des Ruminants domestiquesLes recherdies sur la structure fine du Bulbus olfactorius du Boeuf, du Mouton et de la Chèvre démontrent que, dans les trois espèces, les huit couches, qu'on discerne facilement les unes des autres, ont une structure caractéristique trés semblable et largement conforme à celle des autres Mammiféres. Les différences interspécifiques résident uniquement dans l'épaisseur propre des couches ainsi que dans la grandeur et la disposition des cellules et des faisceaux. Le Bulbus olfactorius accessorius ne présente en outre que ď infimes différences dans sa situation et son développement entre le Boeuf et les Petits Ruminants.ResumenLa estructura fina del bulbo olfatorio de los rumiantes domésticosInvestigaciones sobre la estructura fina del bulbo olfatorio de buey, oveja y cabra demuestran que en las tres especies de animales se encuentran las mismas estructuras de odio capas, bien diferenciadas entre si, que se observan an forma parecida también en los demás mamíferos. Diferencias entre una y otra especie aparecen solo en el espesor de las diversas capas y en el tamaño y la distribución de las células y fibras. Del mismo modo, el bulbo olfatorio accesorio no permite observar grandes diferencias entre el buey y los rumiantes pequeños, en los que se refiere a su situación y su desarrollo.
The Phalangeal Formula of Hemidactylus Oken, 1817 (Reptilia, Gekkonidae): A Correction and a Functional Explanation
Authors: Russell Anthony P. 
Published: June 2007

AbstractThis paper points out a situation in which a particular phalangeal modification in the genus Hemidactylus has been constantly interpreted in an erroneous manner. Conclusions about the actual situation result from the study of a wide range of genera and the modifications discussed may be utilized to set aside a particular assemblage of gekkonine geckos on the basis of the possession of a particular set of synapomorphies. The functional significance of this particular suite of modifications is considered and its probable evolutionary origin outlined. It is pointed out that particular phalangeal modifications are better indicators of phylogenetic affinity than are simple phalangeal counts.
UItrastructure of Theca Interna Cells of Porcine Ovarian Follicle*
Authors: Krzysztofowicz Anna , Stoklosowa Stanislawa 
Published: June 2007

SummaryThe theca interna cells display organelles typical for steroid‐producing cells. This is more obvious in the preovulatory phase than in the luteal phase. Parallel to the growth of the follicle the amount of smooth endoplasmic reticulum, of lipid droplets and of lysosomes increases. Concurrently, the amount of rough endoplasmic reticulum decreases. Junctions of the “abutment nexus” type are more numerous in the preovulatory follicle.ZusammenfassungUltrastruktur von Theca interna‐Zellen aus Eierstockfollikeln vom SchweinDie Theca interna‐Zellen besitzen einen Organellenbestand, der typisch fur Steroidhormon produzierende Zellen ist. Er ist präovulatorisch ausgeprägter als in der davor gelegenen Luteinphase. Parallel zum Follikelwachstum steigt die Menge des glatten endoplasmatischen Retikulum, der Lipidtröpfchen und der Lysosomen. Das rauhe endoplasmatische Retikulum vermindert sich entsprechend. Zellverbindungen vom Typ eines ˝abutment nexus kommen vermehrt praovulatorisch vor.
Anatomy of the Kidneys of a Newly Born Pigmy Hippopotamus (Choeropsis liberiensis Morton)
Authors: Maluf N. S. R. 
Published: June 2007

AbstractThis is probably the first description of the renal anatomy of the pigmy hippopotamus. The observations were made with dissecting and transmitted light microscopes. Nephrons were micro‐dissected from macerated portions of the kidney. The apex of the renal loops is always at the wide helicoidal portion of the nephron and occurs in all zones but especially in the outer zone of the medulla. The kidney is the branched tubus maximus type, similar to that of the Nile hippopotamus. Distinguishing features are indicated and discussed.
A Prominent Consolidation in the Tendon of the Long Head of the Triceps Brachii Muscle in the Greyhound
Authors: McCarthy P. H. 
Published: June 2007

SummaryA description is given of a consistently present and palpable tendinous consolidation located within the tendon of insertion of the long head of the triceps brachii muscle in the greyhound. Its function during flexion of the elbow joint is discussed, and compared with the parapatellar cartilage.
Ultrastructural Changes in the Adrenal Cortex of Rats Exposed to Extremely Low Temperatures
Authors: Vazquez R. , Bermejo F. , Castro A. Martin , Barahona M. 
Published: June 2007

AbstractThe response of the adrenal cortex to low temperature in relation to the length of the exposures is studied. The morphological changes of the adrenal cells, mainly in the Zona fasciculata, are examined. Thirty white rats of both sexes, divided into six groups, were exposed during time intervals of different lengths to temperatures ranging between – 12° and – 15°C. The cellular modifications encountered by means of the electron microscope at the level of the mitochondria, the smooth endoplasmic reticulum and the liposomes are analyzed and compared with the functional situation of the gland in an effort to establish the existence of a correlation between the morphology and the function.
Ultrastructural Classification of Three Different Rat Gonadotrophs after LH‐RH Stimulation
Authors: Seinsch W. , Römmler A. 
Published: June 2007

AbstractThe granule containing cells of the anterior pituitary lobe of metestrous female rats were observed by electronmicroscopy before and after i. v. injection of synthetic LH‐RH. Increased granule release was found in three different types of gonadotrophs after LH‐RH injection. All other known granule containing cells of the gland showed no response to LH‐RH. The three gonadotrophs were morphologically distinguished on the basis of differing cytoplasmic staining and on differences in Golgi aggregation and granule diameters. Furthermore, time‐dependent response‐differences were observed, whereby gonadotroph type I and II responded immediately to LH‐RH stimulation, type III on the other hand with a time‐lag of at least 30 minutes. These time‐related observations indicate that cells of type I and II secret LH, while cells of type III secret FSH.
Die Bildung des Gelenkspaltes, dargestellt am Ellenbogengelenk von Mäuseembryone*
Authors: Püschmann Hans 
Published: June 2007

ZusammenfassungLicht‐ und elektronenmikroskopisch wurde die Entwicklung des Ellen‐bogengelenkes bei Mäusen vom 12. bis 19. Tag post conceptionem (p. c.) unter‐sucht. Im einheitlichen Mesenchym der Extremitatenknospe entwickeln sich am 12. Tag p. c. die Anlagen des Knorpels, die zunächst durch eine breite Interzone voneinander getrennt sind. Die Interzone zeichnet sich durch eine hohe Zahl von Zellkontakten aus. Dadurch entsteht eine zusammenhängende Zellpopulation, deren Aufgabe es ist, durch Synthëse und Sekretion einer hyaluronsaurereichen Interzellularsubstanz erstens das Zusammenfliefien der Knorpelanlagen zu verhindern und zweitens die Bewegung im Gelenk bei Beginn der Funktion zu ermöglichen. Diese Zone verschwindet am 17. Tag p. c. Zu diesem Zeitpunkt ist auch das erste Auftreten eines Gelenkspaltes zu sehen. Bis zur Geburt glätten sich die Gelenkflächen, und die Synovia wird elektro‐nenmikroskopisch sichtbar. In der Diskussion wird auf den unterschiedlichen Modus der Differenzierung und das spätere Schicksal eingegangen, dem die Zellen der Interzone und die Knorpelzellen unterliegen.