bluuebunny/crossref_metadata_2025_split huggingface dataset:
Contrast-Enhanced Ultrasound Features of Primary Hepatic Lymphoepithelioma-Like Carcinoma: Comparison with Hepatocellular Carcinoma
Authors: Qin Hong , Ji Zhengbiao , Zhao Qiannan , Wang Kun , Mao Feng , Han Hong , Wang Wenping 
Published: March 2024

Abstract

Background: Primary hepatic lymphoepithelioma-like carcinoma (LELC) is a malignant tumor with a low incidence, but the number of case reports has increased in recent years. The prognosis of hepatic LELC is better than hepatocellular carcinoma (HCC). The differentiation between hepatic LELC and HCC has clinical value during follow-up treatment. The purpose of our study was to compare contrast-enhanced ultrasound (CEUS) imaging features in patients with hepatic LELC and HCC.

Methods: Twelve patients with an average age of 60.1±9.5 years and histopathologically confirmed hepatic LELC were included in the study. Forty-three patients with an average age of 57.4±9.0 years and a histopathological diagnosis of HCC were designated as the control group by means of propensity score matching (1:4). The clinical data, B-mode ultrasound (BMUS), and CEUS features were retrospectively analyzed between patients with hepatic LELC and HCC.

Results: The serum a-fetoprotein (58.1% [25/43] vs.16.7% [2/12]; p=0.017) and des-gamma-carboxy prothrombin levels (74.4% [32/43] vs.16.7% [2/12]; p=0.001) were not significantly elevated in patients with hepatic LELCs compared to HCCs. LELCs were mainly hypoechoic based on BMUS, while the echogenicity of HCCs varied (p=0.016). A halo sign was less common in patients with hepatic LELCs than HCCs (16.7% [2/12] vs. 58.1% [25/43]; p=0.011). Of hepatic LELCs, 75% (9/12) had homogeneous hyperenhancement based on CEUS, whereas 58.1% (25/43) of HCCs had heterogeneous hyperenhancement (p=0.004). Early washout was noted in 91.7% (11/12) of hepatic LELCs compared to 46.5% (20/43) of HCCs (p=0.005). Furthermore, hepatic LELCs were more likely to exhibit peripheral rim-like hyperenhancement (83.3% [10/12] vs. 11.6% [5/43]; p < 0.001).

Conclusion: BMUS and CEUS are helpful in discriminating between hepatic LELC and HCC. A hypoechoic mass, the rare halo sign, homogeneous hyperenhancement in the arterial phase, higher frequencies of early washout, and peripheral rim-like hyperenhancement are useful ultrasound features that can help differentiate hepatic LELCs from HCCs.
Optimalisasi Desa Wisata Melalui Unit Usaha Jasa Keuangan serta Pemasaran Wisata dan UMKM
Authors: Abdussalam Muhammad , Syahrul Kirom Muhammad , Nofiani Delly , Aminah Siti , Hadi Wijaya Tryana 
Published: March 2024

Dalam perekonomian desa wisata peningkatan program yang mendukung sangat diperlukan dengan upaya yang bisa menjadikan desa wisata terus berkembang dan juga memiliki daya tarik wisatawan yang tinggi. Desa wisata merupakan suatu wilayah pedesaan yang memiliki keunikan dan daya tarik yang khas (baik berupa daya tarik/keunikan fisik lingkungan alam pedesaan maupun kehidupan sosial budaya kemasyarakatan), yang dikelola dan dikemas secara alami dan menarik dengan pengembangan fasilitas pendukung wisata dalam suatu tata lingkungan yang harmonis dan pengelolaan yang baik dan terencana. Melalui unit usaha jasa keuangan akan membantu dalam pengelolaan manajemen keuangan serta pendapatan yang menjanjikan terhadap desa wisata sendiri. Pemasaran wisata dan UMKM menjadi poin penting untuk kemajuan desa wisata, karena dengan baiknya pemasaran maka desa wisata sendiri akan mudah dikenal oleh orang banyak dan menjadi daya tarik yang bisa meningkatkan perekonomian desa wisata. Penulis menggunakan jenis metode deskriptif dengan pendekatan kualitatif langsung berinteraksi dengan objek fenomena yang terjadi melalui kegiatan pengabdian masyarakat. Dengan melalui wawancara, observasi dan dokumentasi maka peningkatan perekonomian desa wisata melalui unit usaha jasa keuangan serta pemasaran wisata dan UMKM disajikan dengan data-data melalui pengabdian kepada masyarakat desa wisata.Kata kunci: Desa wisata; jasa keuangan; pemasaran.
Keragaman Koperasi dan Potensi Pengembangannya
Authors: Kalimansyah Ramdan , Yusuf Efendi Mochamad , Egatmang Perinus , Hotimah Derani , Fitria Rubianti Nur , Hakim Abdul 
Published: March 2024

Praktek lapang yang dilaksanakan di Koperasi Konsumen Pegawai dan Pensiunan PT. PLN Area Bandung, maka kami dapat melihat, mempelajari dan melaksanakan aktivitas koperasi di lapangan yang sebenarnya sehingga kami dapat membandingkan antara praktek dengan teori yang telah kami pelajari selama perkuliahan. Koperasi Konsumen Pegawai dan Pensiunan PT. PLN Area Bandung merupakan koperasi konsumen yang memiliki beberapa unit usaha seperti unit simpan pinjam dan unit usaha poliklinik dan unit usaha tersebut sudah dimanfaatkan oleh anggota dengan baik dalam memenuhi kebutuhannya. Koperasi Konsumen Pegawai dan Pensiunan PT. PLN Area Bandung telah mengimplementasikan konsep jati diri koperasi baik dari aspek definisi, nilai nilai dan prinsip. Namun dalam aspek prinsip dari segi kemandirian, koperasi ini masih belum dikatakan sepenuhnya mandiri karena masih terdapat modal asing yang lebih besar daripada modal sendiri. Adanya beberapa unit usaha yang kinerjanya mulai menurun dikarenakan terdampak oleh situasi pandemi Covid-19 yang menyebabkan terganggunya permodalan koperasi.Kata kunci: koperasi; pengembangan
Efisiensi Biaya Produksi Dalam Meningkatkan Pendapatan Usaha Pada Produk Tahu (Studi Kasus Unit Dagang Tahu Desa Ciwangi)
Authors: Marisa Nita , Mulyawan Thoriq Arief , Nasution Irsyad 
Published: March 2024

UD (Unit Dagang) Tahu Sumedang Pak Aat Ciwangi merupakan unit usaha yang menghasilkan produk tahu dengan melalui proses pengolahan dari bahan baku utama yaitu kedelai yang didirikan pada tahun 2012 oleh Bapak Aat Supriyatna selaku pemilik usaha tahu Sumedang ini. Pengelolaan produksi perusahaan yang kurang efisien tanpa adanya perhitungan yang baik, dan berpengaruh terhadap biaya produksi yang tinggi yang berdampak pada laba atau keuntungan yang di dapatkan rendah. Untuk mengatasi hal ini diperlukan efisiensi biaya yang dapat memulihkan pendapatan atau profitabilitasnya. Dengan demikian Pabrik Tahu ini diharuskan menganalisis faktor yang dapat mempengaruhi kenaikan biaya produksi dan mengendalikan faktor yang dapat menurunkan laba. Diketahui Unit Dagang (UD) Tahu Ciwangi untuk perhitungan dan dapat diperoleh total biaya yang dikeluarkan perusahaan untuk produksi tahu pada tahun 2021 Rp.1.836.050.000. 1) Untuk anggaran biaya bahan baku pada tahun 2021 hasilnya Rp.2.000.000.000 dan realisasi nya sebesar Rp.1.625.000.000 jadi untuk biaya bahan baku sudah efisien. 2) Untuk anggaran biaya tenaga kerja pada tahun 2021 hasilnya Rp. 50.000.000 dan realisasi nya sebesar Rp. 48.750.000 jadi untuk tenaga kerja langsung sudah efisien. 3) Untuk anggaran biaya overhead pabrik pada tahun 2021 hasilnya Rp.180.000.000 dan realisasi nya sebesar Rp.162.300.000 jadi untuk biaya overhead sudah efisien. Total biaya produksi dalam Usaha Dagang (UD) Tahu adalah sebesar Rp.1.836.050.000. Produk yang dihasilkan 650.000 biji tahu dalam satu tahun dengan harga jual 3.000. Maka pendaptan yang diperoleh sebesar Rp. 1.950.000.000 sudah efisien dalam meningkatkan pendapatan.Kata kunci: pendapatan usaha; efisiensi; produk tahu
Peran Badan Usaha Milik Desa (BUMDES) Dalam Upaya Pemberdayaan Masyarakat Perspektif Ekonomi Islam (Studi Kasus Desa Pangkalan Kecamatan Bojong Kabupaten Purwakarta)
Authors: Nurmila Dewi Wilda 
Published: March 2024

Peran Badan Usaha Milik Desa (Bumdes) Dalam Upaya Pemberdayaan Masyarakat Perspektif Ekonomi Islam (Studi Kasus Desa Pangkalan Kecamatan Bojong Kabupaten Purwakarta). Penelitian ini bertujuan untuk mendeskripsikan peran apa saja yang sudah dilakukan oleh BUMDes Pangkalan Tandang Kecamatan Bojong Kabupaten Purwakarta terhadap pemberdayaan masyarakat. Hal tersebut menjadi sangat penting untuk diteliti lebih dalam mengingat bahwa BUMDes Pangkalan Tandang termasuk ke dalam nominasi BUMDes berprestasi di ruang lingkup Kabupaten Purwakarta. Adapun metode yang digunakan pada penelitian ini menggunkan pendekatan studi kasus kualitatif melalui narasumber dari tokoh masyarakat setempat. Berdasarkan analisis data dan temuan di lapangan, dapat disimpulkan peran BUMDes Pangkalan Tandang terhadap pemberdayaan masyarakat bahwa pertama, BUMDes Pangkalan Tandang sebagai motivator, yang mana memanfaatkan masalah menjadi potensi yang dimiliki Desa, sehingga timbul kepercayaan diri masyarakat untuk dapat hidup layak walupun tinggal di desa. Kedua, BUMDes Pangkalan Tandang sebagai Konektifias Lembaga Pembangunan, yang mana BUMDes Pangkalan Tandang memiliki jejaring konektifitas yang kemudian mampu memasarkan hasil produk lokal ke tingkat kabupaten hingga mancanegar. Ketiga, BUMDes Pangkalan Tandang berperan sebagai fasilitator yang mengelola usaha-usaha bersama. Keempat, BUMDes Pangkalan sebagai perusahaan memliki peran pemberdayaan Sumber Daya Manusia untuk dipekerjakan secara profesional.Kata kunci: BUMDes, Pemberdayaan, Masyarakat.
Pengaruh Pemeliharaan Destinasi Wisata Alam Ujung Aspal Indonesia Terhadap Pendapatan Masyarakat
Authors: Budiana U Adis , Thoriq Arief Mulyawan , Adriansyah Hamdan 
Published: March 2024

Penelitian ini dilakukan di daerah destinasi objek wisata atau desa wisata yaitu di Desa Pusakamulya Kecamatan Kiarapedes Kabupaten Purwakarta Jawa Barat, Indonesia. Tujuan penelitian ini adalah 1) Untuk mengetahui Pemeliharaan destinasi wisata alam ujung aspal di desa Pusakamulya kecamatan Kiarapedes kabupaten Purwakarta. 2) Untuk mengetahui pendapatan masyarakat. 3) Untuk mengetahui pengaruh renovasi destinasi wisata alam ujung aspal terhadap pendapatan masyarakat. Penelitian ini menggunakan metode kuantitatif dengan analisis Regresi Linier Sederhana. Teknik pengumpulan data menggunakan metode observasi, kuisioner dan dokumentasi dan diperoleh 30 responden dari para pedagang di destinasi wisata alam ujung aspal. Analisis data menggunakan alat statistik yaitu SPSS versi 25. Berdasarkan hasil pengolahan data dari penyebaran kuesioner, terdapat pengaruh yang signifikan adanya pemeliharaan destinasi wisata alam ujung aspal terhadap pendapatan masyarakat Desa Pusakamulya, Kecamatan Kiarapedes, Kabupaten Purwakarta. Hal ini terlihat dari R Squer sebesar 0,447 atau 44,7% dan hasil analisis regresi diperoleh nilai signifikansi sebesar 0,000 < 0,05 sehingga dapat disimpulkan bahwa terdapat pengaruh yang signifikan antara adanya pemeliharaan destinasi wisata alam ujung aspal terhadap pendapatan masyarakat. Desa Pusakamulya, Kecamatan Kiarapedes, Kabupaten Purwakarta. Kata kunci: Pemeliharaan destinasi wisata alam, pendapatan masyarakat
Global Perspectives on Addressing Systemic Issues in Music Therapy Curricula and Healthcare
Authors: Clements-Cortés Amy , Mercadal-Brotons Melissa , Leonard Hakeem , Chan Vivian , Trondalen Gro , Stingl Tao-Deva , Stegemann Thomas , Zanini Claudia 
Published: March 2024

The discipline of music therapy is practiced differently across the globe and over the years, in all regions of the world, the number of music therapy training programs has expanded. As such, there is a need to reflect on the differences between education and training programs, which vary according to the local culture, educational needs, theoretical background, and scope, among others. Music therapists work in a variety of environments including hospitals, community centres, regular or special education schools, speciality clinics, private practice, and long-term care homes, etc. Music therapists are tasked with navigating policies in their workplaces and balancing the needs of their clients/consumers/service users. This article written together by educators and a student aims to present brief highlights of the work of the authors whose collaboration resulted in a presentation at the European Congress of Music Therapy in June 2022. This presentation focused on the challenges and issues faced by the discipline of music therapy and health in general, based on the analysis of systemic issues in education and training, social issues, and significant issues such as multiculturalism, equity, and race around the world. These were identified as important issues for the authors who desired to raise awareness on these topics to further open ongoing dialogue. Our aim is to contribute to the establishment of dialogues between music therapy educators, allied health professionals, researchers, and students for the implementation of new courses and the updating of existing programs, expanding views on possible music therapy interventions in contemporary times.
Safety assessment of preventive pressurized intraperitoneal aerosol chemotherapy in combined treatment of gastric cancer: preliminary results
Authors: Muratova N. Ya. , Kolobaev I.  V. , Kudryavtsev D.  D. , Smolenov E. I. , Ryabov A. B. , Khomyakov V. M. , Petrov L. O. , Ivanov S. A. , Kaprin A. D. 
Published: March 2024

Purpose of the study. Preventive pressurised intraperitoneal aerosol chemotherapy (PIPAC) safety assessment in the combined treatment of gastric cancer (GC).Patients and methods. The study included 48 patients with morphologically confirmed resectable GC and cardio esophageal transition, having at least one criterion that is a predictor of the development of peritoneal carcinomatosis, e. g. tumor spread to the serous layer (≥ T4a), diffuse tumor type, affected regional lymph nodes, large tumor, young age (up to 45 years), subtotally and totally affected stomach. 36 out of those patients received treatment according to the protocol. All patients received 4 cycles of neoadjuvant chemotherapy according to the FLOT scheme, radical surgical treatment in combination with a PIPAC session, 4 cycles of adjuvant chemotherapy according to the FLOT scheme. The safety assessment was carried out according to the classification of surgical complications according to Clavien-D indo and the international scale for toxicity scaling NCI–CTCAE v5.0.Results. Postoperative complications were diagnosed in 25 %, >III grade complications were revealed in 11 % of cases according to the Clavien-D indo classification. The postoperative mortality rate was 0 %.Conclusion. Preventive PIPAC of locally advanced GC and CET in combined treatment is a reproducible and safe method, which is characterized by the absence of an increase in the number of postoperative complications and mortality rate.
The effect of the relative dose intensity of chemoradiotherapy on the effectiveness of therapy of locally advanced unresectable non-small cell lung cancer
Authors: Glukhareva A. E. , Afonin G. V. , Kolobaev I. V. , Grivtsova L. Yu. , Ivanov S. A. , Kaprin A.  D. 
Published: March 2024

The purpose of the study. To estimate the number of patients with the preservation of relative dose intensity (RDI) ≥ 80 % of first-line antitumor therapy in patients with unresectable non-small cell lung cancer (NSCLC), and to compare the effectiveness of therapy in groups with optimal and lower RDI.Patients and methods. The study included 30 patients (25 men and 5 women) with locally advanced unresectable NSCLC. The median age was 57 years. The main criterion for inclusion in the study was morphologically verified NSCLC with stage IIIB-IIIC of the disease. All patients underwent simultaneous chemoradiotherapy. According to the histogenesis of the tumor process, patients with a squamous cell variant prevailed.Results. The data obtained from 22 (73.3 %) patients who retained a relative dose intensity of RDI > 80 % demonstrated that given dose intensity is sufficient to achieve a stable antitumor effect. In 8 (26.7 %) cases, however, the RDI was less than 80 %, which affected the effectiveness of the treatment. The median follow-up for overall survival (OS) was 29.2 months, progression-free survival (PFS) was 15.1 months, and local control was 21.9 months. in all patients included in the analysis. The indicators of OS in the second year had an advantage in the group of patients with RDI < 80 % and amounted to 73.3 % compared with 60.5 % in patients with RDI > 80 %. PFS was higher in the group of patients with high dose intensity, in the first year of follow-up it was 75.6 % compared with the group of patients with RDI < 80 % (62.5 %), in the second year of follow-up, PFS was 27.2 % and 20.8 %, respectively. Local control was 90.2 % in the first year in the group of patients with RDI > 80 % and 62.5 % in the group of patients with RDI < 80 %. The second year of follow-up demonstrated the advantage of the group of patients with RDI >80 % in terms of local control and amounted to 48.1 % versus 34.7 %, respectively.Conclusion. The results obtained show that maintaining relative dose intensity at a high level has a positive effect on survival rates and local control of patients with locally advanced unresectable NSCLC. However, there is a cohort of patients who did not receive the planned amount of treatment, due to the high toxicity of simultaneous chemoradiotherapy. It is necessary to develop new approaches to concomitant therapy aimed at reducing the toxicity of the combined treatment and achieving maximum antitumor effect.
The organ sparing management of a patient with urachus cancer in conditions of comorbidity
Authors: Ter-Ovanesov M. D. , Yagudaev D. M. , Gritskevich A. A. , Umyarova A. V. , Bezhenar V. A. 
Published: March 2024

Malignant tumors of the urachus are extremely rare. The frequency of urachal malignancy makes 1: 5 000 000 cases, which is 0.35–1.2 % of all the cases of bladder cancer. The small series of observations described in the literature do not allow us to formulate statistically reliable and unambiguously recommended statements about the optimal methods of diagnostics and treatment of this pathology. The diagnosis of urachus diseases is often challenging. This is associated with both the asymptomatic course and the variety of clinical flow of the disease. The treatment strategies are also largely ambiguous and ranging from the defining the indications for surgical treatment to the aggressiveness of surgical intervention. Meanwhile, 20 % of patients with urachal cancer have distant metastases at the time of detection. With everything listed above, (low frequency, little research done and aggressiveness of the flow) it makes every clinical observation of this disease valuable.This article is a clinical observation providing with the information upon the diagnosis, the choice of strategies and surgical treatment of urachal cancer in a patient suffering from multimorbidity. Volumetric formation of the bladder was detected in this patient during additional examination for macrohematuria. Cystoscopy with transurethral resection and subsequent morphological examination verified invasive mucinous adenocarcinoma of the bladder with the growth into the lamina propria and without the signs of vascular and perineural invasion. The patient underwent laparotomy, radical resection of the bladder with extended pelvic lymphadenectomy. The umbilicus, urachus and the bladder wall with the tumor, as well as the adjacent peritoneum, were excised as a single block during the surgical intervention. Morphological examination verified mucinous adenocarcinoma of urachus. The postoperative period was uneventful.There have been no signs of disease progression observed during 10-month follow-up period.
Topaz-bearing Lower Ordovician orthogneiss within the Ostrong Nappe System – The Laimbach Orthogneiss (Bohemian Massif, Lower Austria)
Authors: Geringer Annika , Iglseder Christoph , Klötzli Urs , Grasemann Bernhard , Sláma Jiří 
Published: March 2024

Abstract
In the 1980s, large parts of the Bohemian Massif in Austria were explored for the occurrence of raw materials (Göd, 1988), and a trace content of topaz was discovered in channels draining the eastern slope of the Ostrong (Lower Austria). Orthogneiss bodies in the Ostrong Nappe System are shown to be the source of these topaz occurrences, and Raman spectroscopy indicates that topaz is fluorine rich. So far, this is the only occurrence of topaz-bearing orthogneiss within the entire Moldanubian Superunit. The orthogneiss shows a tectonic overprint and exhibits a weak to well-developed foliation, as well as local folding. Samples taken near the tectonic boundary of the Ostrong to the Drosendorf Nappe Systems show stronger shear deformation with a pronounced mylonitic foliation and stretching lineation. Detailed geo-chemical investigations of the major and trace elements indicate a classification as S-type granite with a high degree of differentiation and a peraluminous character. The orthogneiss has a high SiO2 content of 72.8–77.3 wt%, as well as a noteworthy high fluorine content of up to 2760 ppm. Mineral compositions show zoned plagioclase with an albite component of about 87–99 mol%, increasing towards the grain margin. Garnet occurs rarely, but consistently in those samples near the tectonic boundary of the Ostrong- to the Drosendorf Nappe Systems. Garnet is almandine-dominated, shows no zoning and is single-phased. Sillimanite is common and samples near the tectonic boundary also contain kyanite. To determine the previously unknown protolith age of the orthogneiss, U-Pb zircon dating was applied. Three zircon fractions from two samples yield concordia ages of 475.3 ± 1.0 Ma, 474.8 ± 2.9 Ma, and 473.5 ± 1.5 Ma, identical in assigned uncertainties, reflecting magmatic zircon growth. Furthermore, the short prismatic habit of zircon grains indicates a plutonic rather than volcanic origin of the protolith. Dating results also provide a minimum sedimentation age for the rocks of the Ostrong Nappe System within Austria. In comparison with other metagranitoids and orthogneisses of the Moldanubian Nappes, the investigated orthogneiss shows strong similarities with the Gföhl Gneiss and the Moldanubian Granulite. The orthogneiss therefore is considered as a more fractionated equivalent of the Gföhl Gneiss. In conclusion we suggest to name the studied orthogneiss Laimbach Orthogneiss in the rank of a lithodeme (NACSN, 2005), after the locality Laimbach am Ostrong (48°19′01″N; 15°07′19″E), which is located centrally with respect to the occurrences of this gneiss.
Role of self-efficacy, knowledge sharing, mediated adaptability and external environment change as moderators of readiness for change
Authors: Rismansyah  , Adam Mohamad , Badia Perizade , Yuliani Yuliani 
Published: March 2024

It is vital for higher education to improve its ability to anticipate and implement long-lasting change. Private higher education institutions are currently facing challenges in governance that hinder their ability to upgrade their accreditation grade to "excellent ". The involvement of institutional management is a key factor in enabling these institutions to compete on a national and international level. Research methodology uses confirmatory factor analysis to test the hypotheses developed while structural equation modeling is employed as the equation model. The sample population comprised 16 private tertiary institutions in South Sumatra, Indonesia. The study focused on the heads of study programs resulting in a total of 195 respondents. The results indicated that self-efficacy and knowledge sharing did not have a direct impact on readiness for change whereas adaptability exhibited a direct influence. The study demonstrated that adaptability acts as a mediator between self-efficacy and knowledge sharing towards readiness for change. The final model test results confirmed adaptability as a mediating variable. Additionally, the study revealed that external environmental change did not moderate the relationship between adaptability and readiness for change. Changes of a high calibre that promote a sustained digital education transformation are necessary due to the real-world effects on Indonesia's higher education system. The ability to adapt and embrace new technology is very important factors for higher education performance to face readiness for change in private higher education, especially in management units.