bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sorption‐based treatment of flexographic printing packaging materials ink waste by synthesis of tri‐copolymers via gamma irradiation
Authors: Ibrahim Saber , Fahmy Hager , Lotfy Salah 
Published: April 2024

AbstractThe treatment or recovery of waste ink constitutes a significant process for the printing and packaging industries, particularly in the flexographic printing of packaging materials. This poses a substantial challenge in the field of waste management science. The application of waste ink recovery, ensuring a safe environment and human health, along with the recovery and sustainability of Earth's resources, has garnered significant global attention. The present research is solely devoted to creating innovative trends without technological barriers for synthesizing a tri‐copolymer to be applied as an effective sorption system for waste ink. The Polyethyleneimine‐Poly Glycidyl methacrylate‐polyethylene glycol diacrylate tri‐polymer (PEI‐PGMA‐PEGDA tri‐polymer) was synthesized and thoroughly investigated using FTIR, TGA, and DSC to confirm its chemical structure, thermal stability, and the shift in melting point affected by radiation dose, respectively. SEM analysis showed significant morphological differences in PEI‐PGMA‐PEGDA tri‐polymer samples before and after treatment with flexographic printing ink waste, offering effective strategies for adsorbing waste printing inks from organic solvents. These findings contribute to a comprehensive understanding of the investigated materials and their potential applications. Additionally, the kinetic study of the sorption efficiency of flexographic ink by two sets of tri‐copolymers with doses of 20 and 40 kGy indicated that 40 kGy has a more efficient capacity. The highest sorption capacity, approximately 97.6%, was observed for a sample of GMA 15% irradiated by 40 kGy with a sorption amount of 2.5 g L−1. This suggests that the current new treatment strategy can be categorized as highly effective waste ink management and should be advocated for in such domains to ensure a safe environment and preserve Earth's resources. The treatment of printing ink for packaging materials is a crucial step towards achieving green printing technology, which must be supported and advanced through research and industrial application.
Pig and dog use in the pre‐contact Society Island Chiefdoms: integrated ethnohistoric, archaeological and use‐web analyses
Authors: Kahn Jennifer G. 
Published: April 2024

ABSTRACTPig and dog were highly valued animals in pre‐contact Polynesia. In this paper, I focus on pig and dog use in the resource rich, and hierarchically complex, pre‐contact Society Island chiefdoms. Utilizing ethnohistoric data and human‐centred use‐webs data, I provide a preliminary study of the diverse ways that pigs and dogs were used in pre‐contact Mā‘ohi life across 13 use categories. Ethnohistoric analyses indicate that pigs, and to some extent dogs, were intimately associated with elite ceremonial use, yet pigs were commonly associated with war and fertility rituals, while dogs were commonly associated with peacekeeping events. Preliminary comparison of pig and dog frequencies at eight excavated archaeological sites suggests pig bones far outnumber dog bones. There is also differential recovery of pig and dog bone in terms of site function and site status, with high status temples dating to the Centralization Phase having the highest incidence of both species. It is highly likely that the advent of the ‘Oro war cult led to intensified pig husbandry, given this animal's robust associations with ritual use, moral notions of chiefly power and cosmology. Why dog husbandry was less intensified in the Society Islands, and why this animal was perhaps accessed largely through long‐distance trade relationships, is an ongoing question.
Teaching children with autism spectrum disorder to mand for answers to questions via telehealth: A caregiver implementation
Authors: Swensson Remington M. , Akers Jessica S. , Austin Monserrat , Liu Renming , Swafford Lindsey B. , Gerow Stephanie 
Published: April 2024

AbstractManding for information is important because information is a valuable part of learning and interacting with our environment, allowing for more autonomy (i.e., access reinforcement). Despite the importance of this skill, individuals with autism spectrum disorder (ASD) often do not engage in manding for information without explicit instruction. In the current study, we coached caregivers via telehealth to teach three children with ASD to mand for information using the phrase “I don't know, please tell me” (IDKPTM). All three participants independently engaged in the IDKPTM response for information during intervention and post intervention generalization probes. The results of this study extend the findings of previous research by demonstrating caregivers coached via telehealth can teach their children to mand for more information using the “IDKPTM” phrase. Additionally, the results of this study reflect the benefits of involving caregivers to implement evidence‐based interventions while being coached through telehealth.
Myokines: A central point in managing redox homeostasis and quality of life
Authors: Rathor Richa , Suryakumar Geetha 
Published: April 2024

AbstractRedox homeostasis is a crucial phenomenon that is obligatory for maintaining the healthy status of cells. However, the loss of redox homeostasis may lead to numerous diseases that ultimately result in a compromised quality of life. Skeletal muscle is an endocrine organ that secretes hundreds of myokines. Myokines are peptides and cytokines produced and released by muscle fibers. Skeletal muscle secreted myokines act as a robust modulator for regulating cellular metabolism and redox homeostasis which play a prime role in managing and improving metabolic function in multiple organs. Further, the secretory myokines maintain redox homeostasis not only in muscles but also in other organs of the body via stabilizing oxidants and antioxidant levels. Myokines are also engaged in maintaining mitochondrial dynamics as mitochondria is a central point for the generation of reactive oxygen species (ROS). Ergo, myokines also act as a central player in communicating signals to other organs, including the pancreas, gut, liver, bone, adipose tissue, brain, and skin via their autocrine, paracrine, or endocrine effects. The present review provides a comprehensive overview of skeletal muscle‐secreted myokines in managing redox homeostasis and quality of life. Additionally, probable strategies will be discussed that provide a solution for a better quality of life.
Identification of molecular characteristics of hepatocellular carcinoma with microvascular invasion based on deep targeted sequencing
Authors: Zheng Linlin , Wang Yaru , Liu Zhenrong , Wang Zhihao , Tao Changcheng , Wu Anke , Li Haiyang , Xiao Ting , Li Zhuo , Rong Weiqi 
Published: April 2024

AbstractBackgroundAs an indicator of tumor invasiveness, microvascular invasion (MVI) is a crucial risk factor for postoperative relapse, metastasis, and unfavorable prognosis in hepatocellular carcinoma (HCC). Nevertheless, the genetic mechanisms underlying MVI, particularly for Chinese patients, remain mostly uncharted.MethodsWe applied deep targeted sequencing on 66 Chinese HCC samples. Focusing on the telomerase reverse transcriptase (TERT) promoter (TERTp) and TP53 co‐mutation (TERTp+/TP53+) group, gene set enrichment analysis (GSEA) was used to explore the potential molecular mechanisms of the TERTp+/TP53+ group on tumor progression and metastasis. Additionally, we evaluated the tumor immune microenvironment of the TERTp+/TP53+ group in HCC using multiplex immunofluorescence (mIF) staining.ResultsAmong the 66 HCC samples, the mutated genes that mostly appeared were TERT, TP53, and CTNNB1. Of note, we found 10 cases with TERTp+/TP53+, of which nine were MVI‐positive and one was MVI‐negative, and there was a co‐occurrence of TERTp and TP53 (p < 0.05). Survival analysis demonstrated that patients with the TERTp+/TP53+ group had lower the disease‐free survival (DFS) (p = 0.028). GSEA results indicated that telomere organization, telomere maintenance, DNA replication, positive regulation of cell cycle, and negative regulation of immune response were significantly enriched in the TERTp+/TP53+ group (all adjusted p‐values (p.adj) < 0.05). mIF revealed that the TERTp+/TP53+ group decreased CD8+ T cells infiltration (p = 0.25) and enhanced PDL1 expression (p = 0.55).ConclusionsTERTp+/TP53+ was significantly enriched in MVI‐positive patients, leading to poor prognosis for HCC patients by promoting proliferation of HCC cell and inhibiting infiltration of immune cell surrounding HCC. TERTp+/TP53+ can be utilized as a potential indicator for predicting MVI‐positive patients and poor prognosis, laying a preliminary foundation for further exploration of co‐mutation in HCC with MVI and clinical treatment.
Real‐world data of poly (ADP‐ribose) polymerase inhibitor response in Japanese patients with ovarian cancer
Authors: Uekusa Ryosuke , Yokoi Akira , Watanabe Eri , Yoshida Kosuke , Yoshihara Masato , Tamauchi Satoshi , Shimizu Yusuke , Ikeda Yoshiki , Yoshikawa Nobuhisa , Niimi Kaoru , Suzuki Shiro , Kajiyama Hiroaki 
Published: April 2024

AbstractBackgroundPoly (ADP‐ribose) polymerase (PARP) inhibitors have been increasingly used in the treatment of ovarian cancer, with BRCA positivity and homologous recombination deficiency (HRD) being common biomarkers used for predicting their efficacy. However, given the limitations of these biomarkers, new ones need to be explored.MethodsThis retrospective study included 181 ovarian cancer patients who received olaparib or niraparib at two independent hospitals in Japan between May 2018 and December 2022. Clinical information and blood sampling data were collected. Patient characteristics, treatment history, and predictability of treatment duration based on blood data before treatment initiation were examined.ResultsHigh‐grade serous carcinoma, BRCA positivity, HRD, and maintenance therapy after recurrence treatment were observed more frequently in the olaparib group than in the niraparib group. The most common reasons for treatment interruption were anemia, fatigue, and nausea in the olaparib group and thrombocytopenia in the niraparib group. Regarding response to olaparib treatment, complete response to the most recent treatment, maintenance therapy after the first chemotherapy, high‐grade serous carcinoma, and germline BRCA positivity were observed significantly more frequently among responders than among non‐responders. Furthermore, neutrophil counts were significantly higher among responders than among non‐responders.ConclusionsInflammation‐related blood data, such as neutrophil count, obtained at the initial pre‐treatment visit might serve as potential predictors for prolonged olaparib treatment. While this study offers valuable insights into potential indicators for prolonged olaparib treatment, it underscores the need for more expansive research to strengthen our understanding of PARP inhibitors and optimize treatment strategies in ovarian cancer.
A population study comparing tracheal and lung adenoid cystic carcinoma
Authors: Gu Yu , Lai Songtao , Wang Yang , Yang Juan , Zhou Ping , Chen Tianxiang 
Published: April 2024

AbstractBackgroundThoracic adenoid cystic carcinoma (ACC) is rare, and the differences between tracheal and lung lesions have not been fully understood.MethodsPatients were identified from a Chinese cancer center (FUSCC) (2005–2022) and the Surveillance, Epidemiology, and End Results (SEER) database (2000–2019). Incidence was calculated and trends were quantified. Clinicopathological features and overall survival (OS) were analyzed. Nomograms predicting OS were constructed.ResultsTotally, 55 tracheal adenoid cystic carcinoma (TACC) and 25 lung and bronchus adenoid cystic carcinoma (LACC) were included in a Chinese cohort, 121 TACC and 162 LACC included in the SEER cohort. There were larger tumor sizes, more lymph nodes and distant metastases for LACC than TACC patients. TACC patients are more likely to get local treatments. Patients with LACC had significantly worse median OS than patients with TACC (SEER cohort: 68.0 months vs. 109.0 months, p = 0.001, Chinese cohort: 62.9 months vs. 124.8 months, p = 0.061). Age, lymph node metastasis, distant metastasis and local treatment were identified as independent prognostic factors for OS of TACC. Distant metastasis and local treatment were identified for LACC. Specifically, surgery alone or in combination with radiotherapy is crucial for improving survival in both TACC and LACC. Only TACC benefits from radiotherapy alone, while chemotherapy does not improve survival for either. The nomograms constructed using these factors revealed good prognostic accuracy.ConclusionsLACC is more aggressive and has a worse prognosis than TACC. TACC patients have more opportunities for local treatment, which is important for the prognosis of both TACC and LACC. Nomograms were created for TACC and LACC to aid in personalized survival predictions and clinical decisions.
The inverted U‐shaped relationship between epinephrine and pancreatic ductal adenocarcinoma patients' survival with compensation of lymphocyte
Authors: Li Bing‐Xue , Zhu Xiao‐Cen , Deng Xia‐Xing 
Published: April 2024

AbstractBackgroundThe relationship between epinephrine and cancer can be dose‐dependent in in vivo study. Whether it is the same in human body still needs verification.MethodWe used frozen human pancreatic ductal adenocarcinoma (PDAC) tissues to detect epinephrine content and analyzed its relationship with survival using the K‐M method and Cox regression. Disturbance of blood cell count and C‐reactive protein and identification of related potent intermediary factors were also analyzed.ResultsK‐M plot and Cox regression all showed the inverted U‐shaped relationship between epinephrine and PDAC survival. Lymphocyte adjustment can increase the HRs of epinephrine for PDAC death by >10%.ConclusionEpinephrine played an anti‐tumor or pro‐tumor effect depending on the specific concentration. Circulating lymphocyte count was elevated and might acted as a compensation pathway to reduce the pro‐tumor effect of epinephrine to PDAC.
Treatment outcome and germline predictive factors of ropeginterferon alpha‐2b in myeloproliferative neoplasm patients
Authors: Chen Chih‐Cheng , Kuo Ming‐Chung , Wang Ying‐Hsuan , Pei Sung‐Nan , Huang Ming‐Lih , Chen Chiu‐Chen , Huang Cih‐En , Chen Yi‐Yang , Shih Lee‐Yung 
Published: April 2024

AbstractBackgroundStudies have shown that some single nucleotide polymorphisms (SNPs) could serve as excellent markers in foretelling the treatment outcome of interferon (IFN) in myeloproliferative neoplasms (MPN). However, most work originated from western countries, and data from different ethnic populations have been lacking.MethodsTo gain insights, targeted sequencing was performed to detect myeloid‐associated mutations and SNPs in eight loci across three genes (IFNL4, IFN‐γ, and inosine triphosphate pyrophosphatase [ITPA]) to explore their predictive roles in our cohort of 21 ropeginterferon alpha‐2b (ROPEG)‐treated MPN patients, among whom real‐time quantitative PCR was also performed periodically to monitor the JAK2V617F allele burden in 19 JAK2V617F‐mutated cases.ResultsELN response criteria were adopted to designate patients as good responders if they achieved complete hematological responses (CHR) within 1 year (CHR1) or attained major molecular responses (MMR), which occurred in 70% and 45% of the patients, respectively. IFNL4 and IFN‐γ gene SNPs were infrequent in our population and were thus excluded from further analysis. Two ITPA SNPs rs6051702 A>C and rs1127354 C>A were associated with an inferior CHR1 rate and MMR rate, respectively. The former seemed to be linked to grade 2 or worse hepatotoxicity as well, although the comparison was of borderline significance only (50%, vs. 6.7% in those with common haplotype, p = 0.053). Twelve patients harbored 19 additional somatic mutations in 12 genes, but the trajectory of these mutations varied considerably and was not predictive of any response.ConclusionsOverall, this study provided valuable information on the ethnics‐ and genetics‐based algorithm in the treatment of MPN.
Cobalamins Function as Allosteric Activators of an Angelman Syndrome‐Associated UBE3A/E6AP Variant
Authors: Müller Franziska , Jansen Jasmin , Offensperger Fabian , Eichbichler Daniela , Stengel Florian , Scheffner Martin 
Published: April 2024

AbstractGenetic aberrations of the maternal UBE3A allele, which encodes the E3 ubiquitin ligase E6AP, are the cause of Angelman syndrome (AS), an imprinting disorder. In most cases, the maternal UBE3A allele is not expressed. Yet, approximately 10 percent of AS individuals harbor distinct point mutations in the maternal allele resulting in the expression of full‐length E6AP variants that frequently display compromised ligase activity. In a high‐throughput screen, we identified cyanocobalamin, a vitamin B12‐derivative, and several alloxazine derivatives as activators of the AS‐linked E6AP‐F583S variant. Furthermore, we show by cross‐linking coupled to mass spectrometry that cobalamins affect the structural dynamics of E6AP‐F583S and apply limited proteolysis coupled to mass spectrometry to obtain information about the regions of E6AP that are involved in, or are affected by binding cobalamins and alloxazine derivatives. Our data suggest that dietary supplementation with vitamin B12 can be beneficial for AS individuals.
Advancements in Modelling the Tribocorrosion Current
Authors: Feyzi Mohsen , Stack Margaret M , Hashemi Reza 
Published: April 2024

AbstractTribocorrosion in passive metals involves a complex and interactive mechanism between mechanical and electrochemical actions at a rubbing contact in a corrosive environment. The mechanical wear mechanism disrupts the passive film on the metal surface; and instantly, the metal repassivates and dissolves in the corrosive environment. This surface damage failure can occur in various components such as marine structures and medical implants which can force significant downtime and repair costs. In this article, historical advancement in the well‐known theories and models which have been developed for passivation and tribocorrosion current (as a measure for wear‐accelerated corrosion) is presented and discussed. The strengths and limitations associated with the models are reviewed to generate an overall picture of the progress in the field. The links between different models are also discussed and finally, some possible directions for future research are suggested.
Chiral Metal‐Organic Frameworks with Spectroscopic Methods: Towards Chemical Sensor Devices
Authors: Hubber Angus , Hua Carol 
Published: April 2024

AbstractChiral Metal‐Organic Frameworks (CMOFs) are a rapidly growing field reflecting their potential as selective and sensitive chemical sensors for chiral analytes. The highly tuneable nature of CMOFs enables the size, shape, and non‐covalent interactions to be optimised towards specific analytes to engender strong intermolecular interactions and sensing responses. While CMOFs as chiral chemical sensor devices have been explored with electrochemical methods including differential pulse voltammetry (DPV), bipolar and chemiresistive sensing techniques, the CMOFs as chiral chemical sensors using spectroscopic methods has received significantly less attention. This review examines the synthesis of CMOFs for chemical sensors with spectroscopic methods such as photoluminescence, circular dichroism, and solid‐state nuclear magnetic resonance with a view towards their incorporation into chemical sensor devices. Future directions of the field are highlighted for the generation of functional devices.
The Effect of Basic Ligands and Alkenes on the Regioselectivity of C−H Additions of Tertiary Amines to Alkenes
Authors: Li Da , Wang Yuji , Wang Shiyu , Dong Shunxi 
Published: April 2024

AbstractHighly regioselective C−H alkylation reactions of tertiary anilines and tertiary alkyl amines with simple alkenes have been achieved by the use of imidazolin‐2‐iminato scandium alkyl complexes. This protocol provided an efficient and atom‐economical route to structurally diverse tertiary amine derivatives. The basic ligand, a coordinating THF in the catalyst and the substitution of alkene substrates were found to switch the regioselectivity of the C−H alkylation reactions of tertiary anilines presumably due to the generation of different types of catalytically active species or the formation of relatively stable intermediates. On the basis of the deuterium labeling experiments and KIE experiments, possible catalytical cycles were provided to understand the reaction mechanism as well as the regioselectivity.
Chemical and Chemoenzymatic Synthesis of Peptide and Protein Therapeutics Conjugated with Human N‐Glycans
Authors: Ochiai Hirofumi , Elouali Sofia , Yamamoto Takahiro , Asai Hiroaki , Noguchi Masato , Nishiuchi Yuji 
Published: April 2024

AbstractGlycosylation is one of the most ubiquitous post‐translational modifications. It affects the structure and function of peptides/proteins and consequently has a significant impact on various biological events. However, the structural complexity and heterogeneity of glycopeptides/proteins caused by the diversity of glycan structures and glycosylation sites complicates the detailed elucidation of glycan function and hampers their clinical applications. To address these challenges, chemical and/or enzyme‐assisted synthesis methods have been developed to realize glycopeptides/proteins with well‐defined glycan morphologies. In particular, N‐glycans are expected to be useful for improving the solubility, in vivo half‐life and aggregation of bioactive peptides/proteins that have had limited clinical applications so far due to their short duration of action in the blood and unsuitable physicochemical properties. Chemical glycosylation performed in a post‐synthetic procedure can be used to facilitate the development of glycopeptide/protein analogues or mimetics that are superior to the original molecules in terms of physicochemical and pharmacokinetic properties. N‐glycans are used to modify targets because they are highly biodegradable and biocompatible and have structures that already exist in the human body. On the practical side, from a quality control perspective, close attention should be paid to their structural homogeneity when they are to be applied to pharmaceuticals.
Photoluminescent Carbon Quantum Dots from Dichrostachys glomerata Pods with Antioxidant and Cu2+ Chelating Properties
Authors: Djiazet Steve , Desmarets Christophe , Rinnert Hervé , Jasniewski Jordane , Medjahdi Ghouti , Balan Lavinia , Schneider Raphaël 
Published: April 2024

AbstractThis work presents the facile and single‐step hydrothermal synthesis of carbon quantum dots (CQDs) using the Dichrostachys glomerata extract as raw material. CQDs with the highest photoluminescence (PL) were obtained after heating the extract in 4 M NaOH at 200 °C for 7 h. The obtained CQDs exhibit an average size of ca. 4.7 nm, a green‐yellow PL emission independent on the excitation wavelength with contributions located at 478 and 562 nm, a monoexponential decay of their PL lifetime and a PL quantum yield of 18 %. These results indicate that the surface functionalization of sp2 clusters in CQDs is uniform. The antioxidant properties of CQDs were also investigated. CQDs can effectively reduce free radicals like superoxide or oxidants like KMnO4. Moreover, CQDs show a high Cu2+ chelating activity, which is attributed to the abundant carboxylate functions on their surface and may therefore be of high interest in therapeutic applications related to Cu2+ ions overload.