bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Preclinical Efficacy on GSK‐3 Inhibitors: Towards a Future Generation of Powerful Drugs
Authors: Martinez Ana 
Published: October 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Structure, Physiological Role, and Specific Inhibitors of Human Thymidine Kinase 2 (TK2): Present and Future
Authors: Perez‐Perez Maria‐Jesus , Priego Eva‐Maria , Harnandez Ana‐Isabel , Familiar Olga , Camarasa Maria‐Jose , Negri Ana , Gago Federico , Balzarini Jan 
Published: October 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Cascade and Multicomponent Reactions Towards Rapid Synthesis of Highly Functionalized Cyclobutanes
Authors: Takasu Kiyosei 
Published: October 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Development of Highly Efficient Acid—Base Combination Catalyses Based on Carbon—Metal Bonds Activation in Organometallic Reagents
Authors: Hatano Manabu , Ishihara Kazuaki 
Published: October 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Precision Control in Radical Polymerization — Control of Molecular Weight, Stereochemistry, and Monomer Sequence
Authors: Kamigaito Masami , Satoh Kotaro 
Published: October 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: DNA‐Templated Organic Synthesis (DTS): A Novel Approach to the Discovery of Functional Small Molecules Based on Nature′s Evolutionary Principles
Authors: Sakurai Kaori , Liu David R. 
Published: October 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Super Robust Nanoparticles for Biology and Biomedicine.
Authors: Jin Rongchao 
Published: October 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Light‐Emitting Diodes with Semiconductor Nanocrystals.
Authors: Eychmueller Alexander , et al. et al. 
Published: October 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Asymmetric Catalysis with Metal Complexes in Nanoreactors.
Authors: Yang Qihua , Han Difei , Yang Hengquan , Li Can 
Published: October 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Cold‐ and Pressure‐Induced Dissociation of Protein Aggregates and Amyloid Fibrils.
Authors: Mishra Rajesh , Winter Roland 
Published: October 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Design of Polyvalent Therapeutics
Authors: Joshi Amit , Vance David , Rai Prakash , Thiyagarajan Aditya , Kane Ravi S. 
Published: October 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Metals Coordinate Protein—Protein Interactions.
Authors: Kerman Kagan , Kraatz Heinz‐Bernhard 
Published: October 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Chirality Recognition Between Neutral Molecules in the Gas Phase
Authors: Zehnacker Anne , Suhm Martin A. 
Published: October 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Carbonic Anhydrase Inhibitors: Design of Membrane‐Impermeant Copper(II) Complexes of DTPA‐, DOTA‐, and TETA‐Tailed Sulfonamides Targeting the Tumor‐Associated Transmembrane Isoform IX
Authors: Rami Marouan , Cecchi Alessandro , Montero Jean‐Louis , Innocenti Alessio , Vullo Daniela , Scozzafava Andrea , Winum Jean‐Yves , Supuran Claudiu T. 
Published: October 2008

AbstractThe synthesis and carbonic anhydrase (CA, EC 4.2.1.1) inhibitory activity of two series of aromatic sulfonamides and their CuII derivatives, incorporating metal‐complexing moieties of the DTPA, DOTA, and TETA type are reported. The new compounds were designed in such a way as to possess high affinity for CuII ions, exploiting four pendant carboxylate moieties in the DTPA derivatives, as well as the cyclen/cyclam macrocyles, and three pendant acetate moieties in the DOTA and TETA derivatives. The new derivatives showed modest inhibition of the cytosolic isoform CA I (KI values in the range of 66–2130 nM), were better CA II inhibitors (KI values in the range of 21–360 nM), and excellent inhibitors of the tumor‐associated isoform CA IX (KI values in the range of 4.1–110 nM), with selectivity ratios for the inhibition of the tumor (CA IX) over the cytosolic (CA II) isozyme in the range of 10.74–20.88 for the best derivatives. Copper complexes were more inhibitory than the corresponding ligand sulfonamides, and showed membrane impermeability, thus, having the possibility to specifically target the transmembrane CA IX that has an extracellular active site. Incorporation of radioactive copper isotopes in this type of CA inhibitor may lead to interesting diagnostic/therapeutic applications for such compounds.
Measurement of Slow Diffusion Coefficients of Molecules with Arbitrary Scalar Couplings via Long‐Lived Spin States
Authors: Sarkar Riddhiman , Ahuja Puneet , Vasos Paul R. , Bodenhausen Geoffrey 
Published: October 2008

AbstractNew experiments are described for the determination of very slow diffusion constants by nuclear magnetic resonance (NMR) using long‐lived (singlet) states. These experiments are suitable for molecules or conformations featuring a wide range of J‐couplings.
Determination of Band Structure Parameters and the Quasi‐Particle Gap of CdSe Quantum Dots by Cyclic Voltammetry
Authors: Inamdar Shaukatali N. , Ingole Pravin P. , Haram Santosh K. 
Published: October 2008

AbstractBand structure parameters such as the conduction band edge, the valence band edge and the quasi‐particle gap of diffusing CdSe quantum dots (Q‐dots) of various sizes were determined using cyclic voltammetry. These parameters are strongly dependent on the size of the Q‐dots. The results obtained from voltammetric measurements are compared to spectroscopic and theoretical data. The fit obtained to the reported calculations based on the semi‐empirical pseudopotential method (SEPM)—especially in the strong size‐confinement region, is the best reported so far, according to our knowledge. For the smallest CdSe Q‐dots, the difference between the quasi‐particle gap and the optical band gap gives the electron–hole Coulombic interaction energy (Je1,h1). Interband states seen in the photoluminescence spectra were verified with cyclic voltammetry measurements.
Peripheral blood flow cytometry based diagnosis in primary cutaneous aggressive epidermotropic CD8+ T‐cell lymphoma: Implications for more extensive use
Authors: Benetatos Leonidas , Dova Lefkothea , Baxevanos Gerasimos , Kolaitis Nikolaos I. , Bourantas Konstantinos L. , Vartholomatos Georgios 
Published: October 2008

AbstractPrimary cutaneous epidermotropic CD8‐positive T‐cell lymphoma represents an aggressive form of T‐cell cutaneous lymphomas. Diagnosis is based on biopsies obtained from skin lesions. Here, we would like to report a case diagnosed by using flow cytometry performed on peripheral blood mononuclear cells. Moreover, an important finding was the difference in the results on targeting the CD8 antigen by using two different commercially available monoclonal antibodies. Perhaps, more than one antibody should be used in primary cutaneous aggressive epidermotropic CD8‐positive T‐cell lymphomas, in orderto be more accurate in the diagnosis and so in the classification of such diseases. © 2008 Clinical Cytometry Society
Overexpression of CD7 in classical Hodgkin lymphoma‐infiltrating T lymphocytes
Authors: Seegmiller Adam C. , Karandikar Nitin J. , Kroft Steven H. , McKenna Robert W. , Xu Yin 
Published: October 2008

AbstractBackground:Diagnosis of Hodgkin lymphoma (HL) is sometimes complicated by the scarcity of neoplastic cells in a reactive inflammatory background. Immunophenotyping by flow cytometry (FC) has not played a significant role in HL diagnosis because of its consistent failure to identify these neoplastic cells. However, HL‐infiltrating T cells have been shown to play a role in HL pathogenesis. This study characterizes the FC immunophenotype of these T lymphocytes to determine whether they can be used to assist in the diagnosis of HL.Methods:Cell suspensions from 76 lymph nodes involved by HL and 156 lymph nodes with reactive lymphadenopathy (LAD) were analyzed by flow cytometry to assess the expression of T‐cell antigens.Results:The CD4:CD8 ratio and CD7 expression in both CD4(+) and CD8(+) T cells are increased in HL compared with reactive lymph nodes and there are significant differences between these features in different subtypes of HL. However, only the expression of CD7 in CD4(+) T cells distinguishes between HL and reactive LAD. This is especially true for classical HL in younger patients. Using a CD7 mean fluorescence intensity (MFI) cutoff value generated by this data, 37/47 FNA specimens were correctly diagnosed.Conclusions:There are significant differences in the immunophenotypes of HL‐infiltrating T cells. Of these, the CD7 expression in CD4(+) T cells discriminates between HL and reactive LAD, suggesting that this could be a useful and practical adjunctive tool in the diagnosis of HL. It may also further our understanding of the pathophysiology of this disease. © 2008 Clinical Cytometry Society
On the Nature of VV Species in Hydrophilic Ionic Liquids: A Spectroscopic Approach
Authors: Bányai István , Conte Valeria , Pettersson Lage , Silvagni Adriano 
Published: October 2008

AbstractHeteronuclear NMR experiments, in particular 51V, wereperformed with the aim to elucidate the nature of vanadates and peroxovanadates in hydrophilic ionic liquids (i.e., [bmim][BF4], [bmim][TfO] and [bdmim][BF4]). The data so far reported clearly indicate that ionic liquids have a strong influence on the solution chemistry of vanadate in water both for the formation of the aggregates (with and without H2O2) and for the rate of peroxide consumption catalyzed by vanadium. In BF4– containing ionic liquids, formation of vanadate–fluoride adducts is suggested. The obtained results are also discussed in the light of the reactivity data of peroxovanadates in ionic liquids. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
1,2,4‐Triazolium and Tetrazolium Picrate Salts: “On the Way” from Nitroaromatic to Azole‐Based Energetic Materials
Authors: Klapötke Thomas M. , Miró Sabaté Carles 
Published: October 2008

AbstractA family of energetic salts based on the picrate anion and several azolium cations were synthesized either by new methods or by known literature procedures. The cations of choice were the following: 5‐amino‐1H‐tetrazolium (1), 5‐amino‐1‐methyl‐1H‐tetrazolium (2), 5‐amino‐2‐methyl‐1H‐tetrazolium (3), 5‐amino‐1,4‐dimethyl‐1H‐tetrazolium (4), 5‐amino‐1,3‐dimethyl‐1H‐tetrazolium (5), 1,5‐diamino‐1H‐tetrazolium (6), 1,5‐diamino‐4‐methyl‐1H‐tetrazolium (7), 3,4,5‐triamino‐1,2,4‐triazolium or guanazinium (8) and 3,4,5‐triamino‐1‐methyl‐1,2,4‐triazolium or methylguanazinium (9). A summary of the15N NMR shifts for all compounds is given, and the proton‐/methyl‐induced shifts (PISs/MISs) are discussed with relation to the crystal structures. Because hydrogen bonding plays an important role in determining the density and thus the performance of energetic materials, the crystal structures are discussed in detail. In addition, tests to assess the impact (i) and friction (f) sensitivities of the compounds and thermal stability measurements (DSC) were also carried out, revealing insensitive compounds (i> 40 J,f> 360 N) with high thermal stabilities (Td>175 °C). The constant volume energies of combustion were determined experimentally by oxygen bomb calorimetry and their validity was checked by quantum chemical calculation (MP2) of electronic energies. The detonation pressures and velocities of1(7795 m s–1, 25.6 GPa),2(7343 m s–1, 21.2 GPa),3(7213 m s–1, 20.4 GPa),4(6876 m s–1, 17.8 GPa),5(6846 m s–1, 17.6 GPa),6(7864 m s–1, 25.4 GPa),7(7492 m s–1, 22.1 GPa),8(7495 m s–1, 22.5 GPa) and9(7162 m s–1, 19.8 GPa) were predicted by use of the EXPLO5 code. Lastly, the ICT code was used to predict the decomposition gases of all salts. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Coordination Chemistry of Neutral (Ln)–Z Amphoteric and Ambiphilic Ligands
Authors: Fontaine Frédéric‐Georges , Boudreau Josée , Thibault Marie‐Hélène 
Published: October 2008

AbstractThis review focuses on the coordination chemistry of neutral ambiphilic and amphoteric ligands. The various designs of molecules having both donor and acceptor moieties and the strategies to prevent self‐aggregation and favour transition‐metal coordination will be discussed. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Mono‐ and Bidentate Benzannulated N‐Heterocyclic Germylenes, Stannylenes and Plumbylenes
Authors: Zabula Alexander V. , Hahn F. Ekkehardt 
Published: October 2008

AbstractThe current state of the chemistry of mono‐ and bidentate N‐heterocyclic germylenes, stannylenes, plumbylenes, and related compounds is reviewed with special emphasis placed on benzannulated derivatives. The preparation, electronic structure, aggregation behaviour, and the coordination chemistry of the free benzannulated carbene analogues and their adducts with Lewis bases and complexes with transition metals are discussed. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Multivalent 1‐Oxa‐3,5,7‐triazahepta‐1,3,5‐trienes: Synthesis, Structural Properties and Metal Coordination
Authors: Greving Jan‐Bernd , Behrens Henrik , Fröhlich Roland , Würthwein Ernst‐Ulrich 
Published: October 2008

AbstractNucleophilic ring opening of bis‐ and tris(1‐oxa‐3,5‐diazinium) salts 1 with n‐propylamine leads to the bis‐ and tris(armed) oligonitrile derivatives 3 and 8 with secondary amino groups in the side chain. Alternatively, treatment of simple 1‐oxa‐3,5‐diazinium salts 2 with primary and secondary di‐ and triamines offers a convenient pathway for the synthesis of bis‐ and tris(armed) oligonitriles 4, 5 and 7. 2,6‐Diaminopyridine furnishes the new pincer‐type ligand 6 upon reaction with 1‐oxa‐3,5‐diazinium salt 2a. Multivalent oligonitriles 4, 6, 7 and 8 containing secondary amino groups are able to form intra‐ and intermolecular hydrogen bonds in the solid state as detected by X‐ray crystallography. The oligonitriles 3a,b, 4b,d,h, 6 and 7a form coordination complexes with various ZnII, CuII, CoII, NiII and PdII salts acting as bidentate ligands to give six‐membered chelates of 1:1, 1:2 and 2:2 ligand/metal ion ratios. More complex structures are obtained from pincer ligand 6 with PdCl2 [compound 6·(PdCl2)2] and from the tridentate ligand 7a in reactions with Ni(ClO4)2 (compound 9). All new complexes were characterized by X‐ray crystallography. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Neutral Möbius Aromatics: Derivatives of the Pyrrole Congener Aza[11]annulene as Promising Synthetic Targets
Authors: Mauksch Michael , Tsogoeva Svetlana B. 
Published: October 2008

AbstractAmino‐ and methyl‐disubstituted derivatives of an aromatic 12π electron pyrrole homologue Möbius 1H‐aza[11]annulene are predicted computationally at the B3LYP/6‐31G* level of theory to be distinctly aromatic and a neutral ground state on its potential surface. The parent annulene has a nonaromatic conformation, which is 6.0 kcal mol–1 lower in energy at the CCSD(T)/D95*//B3LYP/6‐31G* level of theory than a structurally very similar Möbius conformation. After derivatization, however, geometry optimizations of the two lowest‐energy – Möbius and non‐Möbius – heteroannulene conformations both converged two a single Möbius minimum, whereas two (Möbius and non‐Möbius) distinct difluoro‐ substituted species could be located 1.8 kcal mol–1 apart in energy at the B3LYP level. The Möbius minimum is 7.5 kcal mol–1 lower in energy at the coupled cluster level than a “Hückel topology” form derived from a known bridged 1H‐[4,9]methano[11]annulene. Several possible reactive modes are investigated in order to assess the relative stability of the Möbius parent annulene. In addition, we report formal novel examples for charged and neutral Möbius triplet aromatic annulenic and heteroannulenic systems, some of which also exhibit distinct aromatic properties. Further fundamental insights into the phenomenon of “Möbius aromaticity” are suggested. The aromaticity of Möbius annulenes is for the first time linked to wavefunction boundary conditions. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Comparative Study of the Chemoselectivity and Yields of the Synthesis of N‐Alkyl‐4‐(trihalomethyl)‐1H‐pyrimidin‐2‐ones
Authors: Zanatta Nilo , Faoro Débora , da S. Fernandes Liana , Brondani Patrícia B. , Flores Darlene C. , Flores Alex F. C. , Bonacorso Helio G. , Martins Marcos A. P. 
Published: October 2008

AbstractThis paper reports a comparative study of the chemoselectivity and yields of the synthesis of N‐alkyl‐4‐(trihalomethyl)‐1H‐pyrimidin‐2‐ones carried out by the cyclocondensation of 4‐alkoxy‐1,1,1‐trihalo‐3‐alken‐2‐ones (enones) with methyl‐ and allylureas with the N‐alkylation of 4‐(trihalomethyl)‐1H‐pyrimidin‐2‐ones with methyl iodide and allyl bromide. To determine the chemoselectivity of the products obtained, all compounds were fully analyzed by 1H and 13C NMR and 2D HMBC spectroscopy. This study has demonstrated that the cyclocondensation reactions give better yields and furnish either N1‐ or N3‐alkylated products depending on both the reaction conditions and the substituents on the enones, whereas the alkylation of pyrimidin‐2‐ones gives lower overall yields and either an N1‐alkylated product or a mixture of N1‐ and O‐alkylated products.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Synthesis of Oligosaccharides Related to a Biodynamic Saponin from Calamus Insignis as Their Propargyl Glycosides
Authors: Dasgupta Somnath , Mukhopadhyay Balaram 
Published: October 2008

AbstractThe total synthesis of the carbohydrate portion (penta‐and tetrasaccharides) of steroidal saponins, isolated fromCalamus insignis, is reported. A simple route is followed, starting from commercially available D‐glucose and L‐rhamnose, through high‐yielding protecting group manipulation strategies. Sulfuric acid immobilized on silica (H2SO4/silica) was used as an effective Brönsted acid source in conjunction with N‐iodosuccinimide for activation of thioglycosides or alone for trichloroacetimidate donors in key glycosylation steps. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Identification of rat urinary glycoproteome captured by three lectins using gel and LC‐based proteomics
Authors: Moon Pyong‐Gon , Hwang Hyun‐Ho , Boo Yong Chool , Kwon Joseph , Cho Je‐Yoel , Baek Moon‐Chang 
Published: October 2008

AbstractMany different types of urine proteome studies have been done, but urine glycoprotein studies are insufficient. Therefore, we studied the glycoproteins from rat urine, which could be used to identify biomarkers in an animal model. First, urinary proteins were prepared by using the dialysis and lyophilizing methods from rat urine. Glycoproteins enriched with lectin affinity purification, concanavalin A, jacalin and wheat germ agglutinin from the urinary proteins were separated by means of reverse‐phase fast protein LC (FPLC) or 1‐D PAGE. Each FPLC fraction and 1‐D PAGE gel band were trypsin‐digested and analyzed by means of nanoLC‐MS/MS. LC‐MS/MS analyses were carried out by using linear ion trap MS. A total of 318 rat urinary glycoproteins were identified from the FPLC fractions and gel bands; approximately 90% of identified proteins were confirmed as glycoproteins in Swiss‐Prot. Many glycoproteins, known as biomarkers, including C‐reactive protein, uromodulin, amyloid beta A4 protein, alpha‐1‐inhibitor 3, vitamin D‐binding protein, kallikrein 3 and fetuin‐A were identified in this study. By studying urinary glycoproteins collected from rat, these results may help to assist in identifying urinary biomarkers regarding various types of disease models.