bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ailments of the Soul
Authors: Beran Ondřej 
Published: March 2024

AbstractThe paper aims to trace the distinctive character of the talk of the soul and to disentangle it from the talk of the mind. The key context will be the way in which we talk about souls that are ailing. As a point of departure, I use the later Wittgenstein’s notion of the soul as anti‐dualist and anti‐substantive, which brings it close to Dennett’s or Davidson’s philosophy of mind, but which Wittgensteinian ethicists have elaborated upon as concerned with matters of good and evil, and beauty. In relation to these concerns, the sense of the ailing soul is different from issues relating to mental health. I then discuss cases of ailments of the soul that would be misleading to analyse as matters of mental health (issues): addiction, racism, and environmental grief. I conclude with a plea for maintaining the talk of the soul as helpful for making sense of existential or beauty‐ or morality‐related ailments, yet as something that does not necessarily subscribe to any doctrine of the soul as a substance. In support, I also use arguments from the spheres of eco‐theology and public theology.
Developmental Channeling and Evolutionary Dappling
Authors: Ramsey Grant , Villegas Cristina 
Published: March 2024

AbstractThe developmental properties of organisms play important roles in the generation of variation necessary for evolutionary change. But how can individual development steer the course of evolution? To answer this question, we introduce developmental channeling as a disposition of individual organisms that shapes their possible developmental trajectories and evolutionary dappling as an evolutionary outcome in which the space of possible organismic forms is dappled—it is only partially filled. We then trace out the implications of the channeling-dappling framework for contemporary debates in the philosophy of evolution, including evolvability, reciprocal causation, and the extended evolutionary synthesis.
Insights from 20 years of mammal population research in Indonesia
Authors: Ardiantiono  , Pinondang Irene M.R. , Chandradewi Desy S. , Semiadi Gono , Pattiselanno Freddy , Supriatna Jatna , Tasirin Johny S. , Winarni Nurul L. , Voigt Maria , Bull Joseph W. , Humle Tatyana , Deere Nicolas J. , Struebig Matthew J. 
Published: March 2024

AbstractMammal populations are declining in biodiverse tropical regions. Global analyses have identified Indonesia as a hotspot of vertebrate decline, although relatively few data are available to substantiate these claims. We reviewed research articles published during 2000–2020 on 104 medium-sized to large terrestrial mammal species found in Indonesia to help inform conservation management and future research. We identified 308 peer-reviewed studies published in English or Bahasa Indonesia, with an increase in publication rate (articles published per year) over time. Studies of species distributions dominated the literature, followed by publications on abundance, species diversity and combinations of these topics. Most publications concerned single-species studies conducted at a single location and a single point in time. We identify four key issues that should be addressed by future research and conservation efforts: (1) disproportionate focus on a small number of species; (2) geographical bias towards west Indonesia (Sumatra, Kalimantan and Java–Bali), with few published studies from central (Sulawesi, Nusa Tenggara and Maluku) and east (Papua) Indonesia; (3) limitations to survey design, sampling effort and data analysis; and (4) lack of long-term wildlife population studies. We also note challenges local researchers face in publishing their studies in international journals because of language barriers and costs. Greater use of existing biodiversity data and continued capacity building for local researchers, particularly those in central and east Indonesia, are critical to effectively guide future wildlife monitoring and improve the conservation status of Indonesian mammals.
No relationship between male pubertal timing and depression – new insights from epidemiology and Mendelian randomization
Authors: Hirtz Raphael , Grasemann Corinna , Hölling Heike , von Holt Björn-Hergen , Albers Nicola , Hinney Anke , Hebebrand Johannes , Peters Triinu 
Published: March 2024

AbstractBackgroundIn males, the relationship between pubertal timing and depression is understudied and less consistent than in females, likely for reasons of unmeasured confounding. To clarify this relationship, a combined epidemiological and genetic approach was chosen to exploit the methodological advantages of both approaches.MethodsData from 2026 males from a nationwide, representative study were used to investigate the non-/linear relationship between pubertal timing defined by the age at voice break and depression, considering a multitude of potential confounders and their interactions with pubertal timing. This analysis was complemented by Mendelian randomization (MR), which is robust to inferential problems inherent to epidemiological studies. We used 71 single nucleotide polymorphisms related to pubertal timing in males as instrumental variable to clarify its causal relationship with depression based on data from 807 553 individuals (246 363 cases and 561 190 controls) by univariable and multivariable MR, including BMI as pleiotropic phenotype.ResultsUnivariable MR indicated a causal effect of pubertal timing on depression risk (inverse-variance weighted: OR 0.93, 95%-CI [0.87–0.99)], p = 0.03). However, this was not confirmed by multivariable MR (inverse-variance weighted: OR 0.95, 95%-CI [0.88–1.02)], p = 0.13), consistent with the epidemiological approach (OR 1.01, 95%-CI [0.81–1.26], p = 0.93). Instead, the multivariable MR study indicated a causal relationship of BMI with depression by two of three methods.ConclusionsPubertal timing is not related to MDD risk in males.
Maternalism. Care and control in diplomatic engagements with civil society
Authors: Jezierska Katarzyna 
Published: March 2024

Abstract
Relations between diplomats and civil society are central to diplomatic work. However, scholarship on diplomacy has not paid sufficient attention to how diplomats interact with civil society actors abroad. This article theorises and empirically examines diplomatic engagements with civil society organisations (CSOs) in host states. The article introduces a new concept – maternalism – into the analytical toolbox of diplomacy studies. While the Bourdieu-inspired ‘practice turn’ has entailed a recalibration of the study of diplomacy towards the everyday work of diplomats, I claim that we need notions that will help us understand these everyday practices in the context of structural power inequalities. In this endeavour, instead of turning to the established notion of paternalism, I follow feminist thinking regarding motherhood and the ethics of care. Maternalism is proposed as a complementary heuristic to paternalism that is helpful in capturing different modes of engagement between unequal actors in international politics and is not marked by financial dependency or military power. Maternalism and paternalism rely on distinct practices of care and control. To empirically illustrate the utility of the notion of maternalism, I analyse diplomats representing seven liberal states in the illiberal states of Poland and Hungary.
Bioethics: No Method—No Discipline?
Authors: Hofmann Bjørn 
Published: March 2024

Abstract
This article raises the question of whether bioethics qualifies as a discipline. According to a standard definition of discipline as “a field of study following specific and well-established methodological rules” bioethics is not a specific discipline as there are no explicit “well-established methodological rules.” The article investigates whether the methodological rules can be implicit, and whether bioethics can follow specific methodological rules within subdisciplines or for specific tasks. As this does not appear to be the case, the article examines whether bioethics’ adherence to specific quality criteria (instead of methodological rules) or pursuing of a common goal can make it qualify as a discipline. Unfortunately, the result is negative. Then, the article scrutinizes whether referring to bioethics institutions and professional qualifications can ascertain bioethics as a discipline. However, this makes the definition of bioethics circular. The article ends by admitting that bioethics can qualify as a discipline according to broader definitions of discipline, for example, as an “area of knowledge, research and education.” However, this would reduce bioethics’ potential for demarcation and identity-building. Thus, to consolidate the discipline of bioethics and increase its impact, we should explicate and elaborate on its methodology.
Modeling Ocean Circulation and Ice Shelf Melt in the Bellingshausen Sea
Authors: Hyogo Shuntaro , Nakayama Yoshihiro , Mensah Vigan 
Published: March 2024

AbstractThe ice shelves in the Bellingshausen Sea are melting and thinning rapidly due to modified Circumpolar Deep Water (mCDW) intrusions carrying heat toward ice‐shelf cavities. Observations are, however, sparse in time and space, and extensive model‐data comparisons have never been possible. Here, using a circulation model of the region and ship‐based observations, we show that the simulated water mass distributions in several troughs traversing mCDW inflows are in good agreement with observations, implying that our model has the skills to simulate hydrographic structures as well as on‐shelf ocean circulations. It takes 7.9 and 11.7 months for mCDW to travel to the George VI Ice Shelf cavities through the Belgica and Marguerite troughs, respectively. Ice‐shelf melting is mainly caused by mCDW intrusions along the Belgica and Marguerite troughs, with the heat transport through the former being ∼2.8 times larger than that through the latter. The mCDW intrusions toward the George VI Ice Shelf show little seasonal variability, while those toward the Venable Ice Shelf show seasonal variability, with higher velocities in summer likely caused by coastal trapped waves. We also conduct particle experiments tracking glacial meltwater. After 2 years of model integration, ∼33% of the released particles are located in the Amundsen Sea, supporting a linkage between Bellingshausen Sea ice‐shelf meltwater and Amundsen Sea upper ocean hydrography.
An underwater vest containing an antioxidant MXene hydrogel for sensitive recognition of fish locomotion
Authors: Yang Chengxiu , Hu Jiafei , Liu Lihui , Wu Shaowei , Pan Mengchun , Liu Yan , Wang Haomiao , Li Peisen , Zhang Qi , Qiu Weicheng , Luo Huihui 
Published: March 2024

AbstractThe perception of fish locomotion is important for understanding their adaptive behaviors and ethological characteristics. However, the main strategy used for extracting fish attitudes involves the use of a vision-based monitoring system, which is limited in its range of observation and cannot perform tracking for long times. Here, we report the use of a wearable tagging electronic device, referred to as an underwater vest, to capture the surrounding flow field disturbances triggered by swimming or momentary postural changes. All of these goals were achieved by integrating a pair of pseudocapacitive pressure-sensing units and a flexible circuit board. Notably, additional conditions, such as variable hydraulic pressures and minimal changes in fish posture, require high stability and sensitivity of the sensing units. Thus, hybrid hydrogel electrodes were developed through cross-linking MXene with holey-reduced graphene oxide nanosheets and further modification with 1-ethyl-3-methylimidazolium dicyanamide ionic liquids, which increased the interfacial capacitance and long-term interfacial activity of the MXene. Consequently, the sensing unit exhibited ultrahigh sensitivity (Smax~136,207 kPa−1) in an aquatic environment for 60 days and superior high-pressure resolution (10 Pa) within a wide working range of 1 MPa. Ultimately, an underwater vest integrated with such sensing units clearly distinguished and recorded fish locomotion. We believe that the designed device may open avenues in flow field monitoring and ocean current detection and provide new insights into the development of sensitive underwater tagging.
Colorectal cancer cells secreting DKK4 transform fibroblasts to promote tumour metastasis
Authors: Li Xue , Chen Yulin , Lu Ran , Hu Min , Gu Lei , Huang Qiaorong , Meng Wentong , Zhu Hongyan , Fan Chuanwen , Zhou Zongguang , Mo Xianming 
Published: March 2024

AbstractWnt/β-catenin signalling is aberrantly activated in most colorectal cancer (CRC) and is one key driver involved in the initiation and progression of CRC. However, mutations of APC gene in CRC patients retain certain activity of APC protein with decreased β-catenin signalling and DKK4 expression significantly upregulates and represses Wnt/β-catenin signalling in human CRC tissues, suggesting that a precisely modulated activation of the Wnt/β-catenin pathway is essential for CRC formation and progression. The underlying reasons why a specifically reduced degree, not a fully activating degree, of β-catenin signalling in CRC are unclear. Here, we showed that a soluble extracellular inhibitor of Wnt/β-catenin signalling, DKK4, is an independent factor for poor outcomes in CRC patients. DKK4 secreted from CRC cells inactivates β-catenin in fibroblasts to induce the formation of stress fibre-containing fibroblasts and myofibroblasts in culture conditions and in mouse CRC xenograft tissues, resulting in restricted expansion in tumour masses at primary sites and enhanced CRC metastasis in mouse models. Reduced β-catenin activity by a chemical inhibitor MSAB promoted the CRC metastasis. Our findings demonstrate why reduced β-catenin activity is needed for CRC progression and provide a mechanism by which interactions between CRC cells and stromal cells affect disease promotion.
Perinatal compromise affects development, form, and function of the hippocampus part one; clinical studies
Authors: White Tegan A. , Miller Suzanne L. , Sutherland Amy E. , Allison Beth J. , Camm Emily J. 
Published: March 2024

Abstract
The hippocampus is a neuron-rich specialised brain structure that plays a central role in the regulation of emotions, learning and memory, cognition, spatial navigation, and motivational processes. In human fetal development, hippocampal neurogenesis is principally complete by mid-gestation, with subsequent maturation comprising dendritogenesis and synaptogenesis in the third trimester of pregnancy and infancy. Dendritogenesis and synaptogenesis underpin connectivity. Hippocampal development is exquisitely sensitive to perturbations during pregnancy and at birth. Clinical investigations demonstrate that preterm birth, fetal growth restriction (FGR), and acute hypoxic-ischaemic encephalopathy (HIE) are common perinatal complications that alter hippocampal development. In turn, deficits in hippocampal development and structure mediate a range of neurodevelopmental disorders, including cognitive and learning problems, autism, and Attention-Deficit/Hyperactivity Disorder (ADHD). In this review, we summarise the developmental profile of the hippocampus during fetal and neonatal life and examine the hippocampal deficits observed following common human pregnancy complications.

Impact

The review provides a comprehensive summary of the developmental profile of the hippocampus in normal fetal and neonatal life.

We address a significant knowledge gap in paediatric research by providing a comprehensive summary of the relationship between pregnancy complications and subsequent hippocampal damage, shedding new light on this critical aspect of early neurodevelopment.
Lactobacillus casei Shirota probiotic drinks reduce antibiotic associated diarrhoea in patients with spinal cord injuries who regularly consume proton pump inhibitors: a subgroup analysis of the ECLISP multicentre RCT
Authors: Wong Samford , Hirani Shashivadan P. , Forbes Alastair , Kumar Naveen , Hariharan Ramaswamy , O’Driscoll Jean , Sekhar Ravi , Jamous Ali 
Published: March 2024

Abstract
Study design
This was a sub-group analysis of a multicentre, randomised, placebo-controlled, double-blind trial (ECLISP trial)

Objectives
To assess the efficacy of a probiotic containing at least 6.5 × 109 live Lactobacillus casei Shirota (LcS) in preventing antibiotic associated diarrhoea (AAD) in patients with spinal cord injury (SCI) who consumed proton pump inhibitor (PPI) regularly. LcS or placebo was given once daily for the duration of an antibiotic course and continued for 7 days thereafter. The trial was registered with ISRCTN:13119162.

Setting
Three SCI centres (National Spinal Injuries Centre, Midland Centre for Spinal Injuries and Princess Royal Spinal Cord Injuries Centre) in the United Kingdom

Methods
Between November 2014, and November 2019, 95 eligible consenting SCI patients (median age: 57; IQ range: 43-69) were randomly allocated to receive LcS (n = 50) or placebo (n = 45). The primary outcome is the occurrence of AAD up to 30 days after finishing LcS/placebo.

Results
The LcS group had a significantly lower incidence of AAD at 30 days after finishing the antibiotic course (28.0 v 53.3%, RR: 95% CI: 0.53, 0.31–0.89; z = 2.5, p = 0.01). Multivariate logistic regression analysis identified that LcS can reduce the risk of AAD at 30 days (OR: 0.36, 95% CI 0.13, 0.99, p < 0.05). No intervention-related adverse events were reported during the study.

Conclusions
LcS has the potential to prevent AAD in what could be considered a defined vulnerable group of SCI patients on regular PPI. A confirmatory, randomised, placebo-controlled study is needed to confirm this apparent therapeutic success to translate it into appropriate clinical outcomes.

Sponsorship
Yakult Honsha Co., Ltd.
Is painful temporomandibular disorder a real headache for many patients?
Authors: Yakkaphan Pankaew , Elias Leigh-Ann , Ravindranath Priya Thimma , Renton Tara 
Published: March 2024

AbstractTemporomandibular disorders (TMDs) and primary headaches are common pain conditions and often co-exist. TMD classification includes the term ‘headache secondary to TMD' but this term does not acknowledge the likelihood that primary headache pathophysiology underpins headache causing painful TMD signs and symptoms in many patients. The two disorders have a complex link and we do not fully understand their interrelationship. However, growing evidence shows a significant association between the two disorders. This article reviews the possible connection between temporomandibular disorders and primary headaches, specifically migraine, both anatomically and pathogenetically.
Combination of EZH2 and ATM inhibition in BAP1-deficient mesothelioma
Authors: Landman Nick , Hulsman Danielle , Badhai Jitendra , Kopparam Jawahar , Puppe Julian , Pandey Gaurav Kumar , van Lohuizen Maarten 
Published: March 2024

Abstract
Background
More than half of mesothelioma tumours show alterations in the tumour suppressor gene BAP1. BAP1-deficient mesothelioma is shown to be sensitive to EZH2 inhibition in preclinical settings but only showed modest efficacy in clinical trial. Adding a second inhibitor could potentially elevate EZH2i treatment efficacy while preventing acquired resistance at the same time.

Methods
A focused drug synergy screen consisting of 20 drugs was performed by combining EZH2 inhibition with a panel of anti-cancer compounds in mesothelioma cell lines. The compounds used are under preclinical investigation or already used in the clinic. The synergistic potential of the combinations was assessed by using the Bliss model. To validate our findings, in vivo xenograft experiments were performed.

Results
Combining EZH2i with ATMi was found to have synergistic potential against BAP1-deficient mesothelioma in our drug screen, which was validated in clonogenicity assays. Tumour growth inhibition potential was significantly increased in BAP1-deficient xenografts. In addition, we observe lower ATM levels upon depletion of BAP1 and hypothesise that this might be mediated by E2F1.

Conclusions
We demonstrated the efficacy of the combination of ATM and EZH2 inhibition against BAP1-deficient mesothelioma in preclinical models, indicating the potential of this combination as a novel treatment modality using BAP1 as a biomarker.
Diagnostic and therapeutic challenges in acute retinal necrosis; an update
Authors: Kalogeropoulos Dimitrios , Afshar Farid , Kalogeropoulos Chris , Vartholomatos Georgios , Lotery Andrew John 
Published: March 2024

AbstractAcute retinal necrosis (ARN) is a rare but severe ophthalmic pathology defined by panuveitis, retinal necrosis, and high rates of retinal detachment. ARN may lead to poor visual outcomes even if promptly diagnosed and treated. ARN may present with a wide spectrum of clinical findings compatible with panuveitis including anterior uveitis, scleritis, vitritis, necrotizing retinitis, occlusive vasculitis, and optic disc edema. The American Uveitis Society introduced clinical criteria in 1994 for the diagnosis of ARN, while more recent criteria have been proposed by the Standardization of Uveitis Nomenclature (SUN) Working Group and the Japanese ARN Study Group. Multimodal imaging is a valuable tool in evaluating patients with ARN, particularly in unusual cases, while utilizing retinal imaging and applying AI algorithms in these areas of clinical research could be highly beneficial. Over the last few years, significant progress has been made in achieving timely diagnosis and treatment. The precise identification of the viral cause in suspected ARN cases has been greatly enhanced by the advancements in PCR techniques and flow cytometry used for intraocular fluids. systemic (intravenous or oral) antivirals with adjunctive intravitreal antiviral therapy are recommended as first-line therapy to reduce disease severity, the risk of vision loss, and retinal detachment incidence. Although aciclovir was the first existing antiviral agent, at present many clinicians prefer high-dose valaciclovir orally or intravenous aciclovir combined with intravitreal foscarnet. Despite significant progress in diagnosing and treating ARN, further research is needed to improve visual outcomes in this challenging clinical condition.
A novel NFKB1 variant in a Japanese pedigree with common variable immunodeficiency
Authors: Nakatani Naoko , Tamura Akihiro , Hanafusa Hiroaki , Nino Nanako , Yamamoto Nobuyuki , Awano Hiroyuki , Tanaka Yasuhiro , Morisada Naoya , Uemura Suguru , Saito Atsuro , Hasegawa Daiichiro , Nozu Kandai , Kosaka Yoshiyuki 
Published: March 2024

Abstract
Recently, heterozygous loss-of-function NFKB1 variants were identified as the primary cause of common variable immunodeficiency (CVID) in the European population. However, pathogenic NFKB1 variants have never been reported in the Japanese population. We present a 29-year-old Japanese woman with CVID. A novel variant, c.136 C > T, p.(Gln46*), was identified in NFKB1. Her mother and daughter carried the same variant, demonstrating the first Japanese pedigree with an NFKB1 pathogenic variant.