bluuebunny/crossref_metadata_2025_split huggingface dataset:
Regulation for the Translation of Gene and Cell Therapy into Medical Practice in East Asian Countries
Authors: Melnikova E. V. , Merkulov V. A. , Merkulova O. V. 
Published: February 2024

SCIENTIFIC RELEVANCE. Currently, the Russian Federation lacks a comprehensive regulatory framework for the use of gene and cell therapy (GCT) products. There is no standard for conducting clinical trials for purposes other than marketing authorisation in Russia. In contrast, international practice shows that, in addition to marketing authorisation, including approval based on incomplete data with post-approval commitments, there are regulatory mechanisms for the use of unregistered GCT products, such as hospital exemptions, expanded access, or compassionate use in the European Union and the USA. Relatively recently, this framework has been reformed in East Asian countries.AIM. This study aimed to analyse the regulatory mechanisms for translating GCT products into medical practice in East Asian countries and to assess the possibility of transferring elements of international experience to Russian practice.DISCUSSION. East Asian countries have adopted legislation on requirements for the manufacturing and medicinal use of GCT products. These requirements include having a mandatory license for production in accordance with Good Manufacturing Practice, consideration of the rationale for the use of GCT products by regulatory authorities or special committees, risk classification of investigational GCT products, approved registries of medical institutions authorised to use GCT products, and necessary monitoring and control of patients after GCT administration. Only cellbased innovative medicines, including genetically modified cells, are used within the framework of medical technologies (Japan, China, and Taiwan) or services (Republic of Korea), and in vivo gene therapy products can be used only in investigator-initiated clinical trials.CONCLUSIONS. The East Asian experience in translating GСT products into medical practice would be extremely useful for the Russian Federation, especially in terms of GСT use for specific indications based on accumulated clinical experience. The review suggests that it would be appropriate to establish legal provisions for investigator-initiated clinical research in Russian national legislation.
Meningkatkan Motorik Halus Anak Melalui Metode Mewarnai Di Ra An-Nur
Authors: Saadah Nur , Khairi Rizka , Anggraini Melvi Sari , Fajri Yasmina 
Published: February 2024

Kegiatan mewarnai merupakan kegiatan yang berfungsi untuk melatih motorik halus dalam setiap pergerakan jemari tangannya. Mewarnai pada anak usia dini adalah curahan dari apa yang ada dalam fikirannya, meskipun hasilnya terkadang tidak sesuai dengan apa yang kita harapkan. Tujuan dari penelitian ini adalah untuk mengembangkan keterampilan motorik halus anak menggunakan metode gambar berwarna. Baik subjek maupun tempat penelitian adalah anak-anak, terdiri dari 20 anak, 12 perempuan dan 8 laki-laki. Desain Kemmis dan Mc Taggart digunakan secara bersiklus dalam penelitian ini. Mengumpulkan data melalui observasi, penugasan, dan pencatatan, dilanjutkan dengan analisis deskriptif. Pewarnaan gambar meningkatkan kemampuan motorik halus anak dan terbukti berkembang dari siklus satu ke siklus dua. Memegang Alat warna BSB, BSH, dan MB mempertahankan intensitas 80% hingga 95% (15%). Fleksibilitas menggerakkan pergelangan tangan BSB, BSH, dan MB dari 85% menjadi 90% (5%). Bersih dalam mewarnai pada kelas BSB, BSH dan MB memiliki kemurnian 80% - 90% (10%). Secara keseluruhan kategori BSB, BSH, dan MB mengalami peningkatan rata-rata sebesar 11,66 dari siklus I ke siklus II. Namun masih ada beberapa orang yang kemampuan motorik halusnya belum meningkat atau BB. Metode mewarnai gambar dapat meningkatkan kemampuan motorik halus anak, hasil menunjukkan di R.A An-Nur kecamatan Medan Johor. Kata kunci: Metode Mewarnai, Keterampilan Motorik Halus
Pengaruh Aplikasi E-Flashcard Untuk Pengenalan Kosakata Bahasa Inggris Pada Anak Usia Dini Di Taman Kanak-Kanak Nur Ilaahi Lubuk Buaya Kota Padang
Authors: Lesta Hasni , Pransiska Rismareni 
Published: February 2024

Penelitian ini dilatar belakangi oleh rendahnya upaya memperkenalkan kosakata bahasa inggris pada anak, hal tersebut diakibatkan oleh terbatasnya media ajar yang menarik pada proses belajar di TK Nur Ilaahi Lubuk Buaya Kota Padang. Jenis dari penelitian ini termasuk penelitian kuantitatif melalui metode eksperimen berupa quasy eksperimen. Populasi pada penelitian ini yakni semua anak pada TK Nur Ilaahi, dengan sampel B1 dan B2 yang setiap kelas dengan jumlah 10 anak. Teknik dalam mengumpulkan data melalui penggunaan test dimana terdapat 5 butir item instrument pernyataan. Teknik dalam menganalisis data melalui cara melakukan perbandingan perbedaan dari dua rata-rata nilai, yang mana dilaksanakan uji t (t-test) melalui bantuan program SPSS 19 for windows. Namun sebelumnya melaksanakan pengujian normalitas dan homogenitas terlebih dahulu. Berdasarkan hasil analisis data, rata-rata pre-test grup eksperimen 12,90 dan grup kontrol 12,00. Berdasarkan nilai sig (2-tailed) adalah 0,016<0,05. Sehingga bisa diraih kesimpulan dimana pengaruh aplikasi e-flashcard memberikan dampak akan pengenalan kosakata bahasa inggris pada anak usia dini pada Taman Kanak-Kanak Nur Ilaahi Lubuk Buaya Kota Padang. Kata kunci: Aplikasi E-Flashcard, Kosakata Bahasa Inggris, Anak Usia Dini
Қазіргі қазақ әңгімелеріндегі «періге ғашық болу» мотиві (Қ.Мүбарак әңгімелерінің негізінде)
Authors: Сыздықова Б.Е. 
Published: February 2024

Ғылымда «адамзат санасынан бөлек абстрактілі өмір бар» деген тұжырым бар. Мақалада дүниелік өлшемнің сыртында өмір сүретін мистикалық, мифологиялық бейнелер, оның ішінде «пері» образының қазіргі қазақ әңгімелеріндегі қолданысы адамзаттың таным-түсінігімен, наным-сенімімен мәдениетімен сабақтастыра отырып, мифтік, фольклорлық шығармада кездесетін сюжеттер желісімен салыстырмалы түрде талданған. Мифтік ойлау, мифтік сарындардың қазіргі қазақ жазушыларының көркемдік әлеміндегі алатын орны айқындалады. Көне мифтің қазіргі поэтикалық жүйедегі әдістәсілдері Қ.Мүбарак әңгімелеріндегі қолданыстары негізінде нақтыланады. «Перінің қыздары» образына талдау жасай отырып, әдебиеттегі жеке авторлық бейнелер мен мотивтердің жасырын мифологиясын айқындауға, мифологиялық және фольклорлық көріністердің авторлық мәтіндегі өзара әрекеттесу процесін анықтауға ұмтылыс жасалады
Ảnh hưởng của từ biến trong dầm thép liên hợp với bản bê tông Geopolymer
Authors: Hà Nguyễn Bình , Bảo Nguyễn Quốc , Danh Lê Bá , Quang Vũ Thành 
Published: February 2024

Tóm tắt
Bê tông Geoplymer (GPC) là loại bê tông sử dụng chất kết dính Geopolymer được chế tạo từ tro bay, xỉ lò cao, mê ta cao lanh v.v… kết hợp với chất hoạt hóa kiềm. Sử dụng dầm thép liên hợp với bản GPC ngoài việc phát huy được các ưu điểm của kết cấu liên hợp còn giảm phát thải khí CO2. Một đặc điểm quan trọng khác là biến dạng do từ biến của GPC nhỏ hơn đáng kể so với bê tông thường vì vậy khả năng ảnh hưởng do từ biến của GPC sẽ nhỏ hơn bê tông thường, bài báo này sẽ đánh giá ảnh hưởng do từ biến của GPC với bê tông thường trong kết cấu liên hợp bằng cách sử dụng công thức xác định ảnh hưởng do từ biến của bản bê tông trong kết cấu dầm liên hợp có kể đến độ cứng uốn của bản bê tông, và qua đó đề xuất việc tính toán ảnh hưởng của từ biến trong kết cấu dầm thép liên hợp với bản GPC.
Từ khóa: geopolymer; dầm thép bê tông liên hợp; từ biến; tỷ số mô đun đàn hồi; bản mặt cầu.
EFFECTS OF CREEP IN COMPOSITE STEEL BEAM WITH GPC SLABS
Abstract
Geoplymer concrete (GPC) is a type of concrete that uses Geopolymer binder made from fly ash, blast furnace, metakaolinite, etc. combined with Alkaline activator. Using steel girder composite with Geoplymer concrete slab, in addition to promoting the advantages of composite structural, also reduces CO2 gas emissions. Another important point is that the creep deformation of GPC is significantly smaller than that of normal concrete, therefore may the creep effect of GPC will be smaller than that of normal concrete. This article will evaluate the creep effect of GPC with conventional concrete in the composite girder by using the formula to determine the creep effect of concrete slab in the composite girder taking into account the bending stiffness of the concrete slab, and thereby propose the calculation impact of creep in steel girder composite with GPC slab.
Keywords: geopolymer, steel concrete composite girder, creep, elasticity modulus ratio, slab.
Keanekaragaman dan Peran Ekologis Serangga Tanah di Kawasan Hutan Rafae Kecamatan Raimanuk Kabupaten Belu
Authors: Tae Valerian Yunito , Seran Yoseph Nahak , Bani Polikarpia Wilhelmina 
Published: February 2024

Serangga tanah merupakan jenis dari serangga yang seluruh atau sebagian hidupnya ditemukan di permukaan tanah. Berdasarkan tingkat trofiknya serangga dibagi menjadi 3 jenis yaitu, serangga herbivora, serangga karnivora dan serangga dekomposer. Penelitian ini bertujuan untuk mengetahui : Untuk menganalisis jenis serangga tanah yang terdapat di Kawasan hutan Rafae Kecamatan Raimanuk Kabupaten Belu, Untuk menganalisis Bagaimana indeks keanekaragaman serangga di Kawasan hutan Rafae Kecamatan Raimanuk Kabupaten Belu Penelitian dilakukan pada bulan September – November 2022. Penelitian ini bersifat deskriptif-eksploratif. Metode yang digunakan pada penelitian ini yaitu metode Pitffall trap. Hasil penelitian yang di dapat Pada Kawasan Hutan Rafae Kecamatan Raimanuk Kabupaten Belu Ditemukan 14 jenis serangga tanah yang terdiri dari 11 famili serangga dan 5 ordo dengan jumlah individu 364 jenis serangga, dari 12 perangkap yang di pasang pada 2 plot. Spesies serangga tanah yang ditemukan terdapat spesies serangga tanah yang berperan sebagai polinator, dekomposer, predator, parasitoid dan bioindikator.
PENERAPAN METODE FUZZY MAMDANI TERHADAP TINGKAT KEPUASAN PELANGGAN BERDASARKAN HARGA DAN KUALITAS PELAYANA
Authors: Septiawati Anggita , Arman  , Muhtar Norma , Somayasa Wayan , Alfian  
Published: February 2024

Pada penelitian ini dibahas mengenai tingkat kepuasan pelanggan yang dibuat dalam metode fuzzy mamdani. Kepuasaan pelanggan menjadi salah satu faktor terpenting dalam dunia pebisnis sehingga kepuasan pelanggan menjadi tolak ukur yang harus diperioritaskan oleh pelaku pebisnis. Untuk mengukur kepuasan pelanggan terdapat berbagai hal yang harus diperhatikan tidak hanya dari segi rasa, kualitas pelayanan dan harga juga sangat berpengaruh terhadap tingkat kepuasan pelanggan, sehingga untuk tingkat kepuasan pelanggan di Warkop Kopi Kita menggunakan metode fuzzy mamdani dan dibantu dengan Microsofft Office Ecsel. Untuk mendapatkan nilai output dilakukan dalam beberapa tahap yaitu: pembentukan himpunan fuzzy, menentukan fungsi keanggotaan, menentukan fungsi implikasi dan komposisi aturan dimana pada metode mamdani, fungsi implikasi yang digunakan adalah min dalam persamaan operator fuzzy and sedangkan komposisi aturan yang digunakan pada metode mamdani yaitu aplikasi max dari operator fuzzy or, melakukan penegasan( defuzzyfikasi). Ada 2 variabel input yang digunakan yaitu harga dan kepuasan pelanggan, dan ada 1 output yang digunakan yaitu kepuasaan pelanggan. Logika fuzzy merupakan sistem untuk memecahkan masalah, dengan menerapkan logika fuzzy dalam mendukung keputusan yang akan diambil diharapkan menghasilkan suatu keputusan sesuai dengan yang diharapkan. Dengan mengetahui tingkat kepuasan pelanggan tersebut tentunya Warkop Kopi Kita dapat mengetahui tingkat kepuasan yang didapatkan dari pelanggan yang berkunjung ke Warkop Kopi Kita.
SIFAT-SIFAT MATRIKS KETETANGGAAN PADA GRAF RODA
Authors: Nasrul  , Arman  , Jufra  , Somayasa Wayan , Budiman Herdi 
Published: February 2024

Graf roda merupakan graf yang diperoleh dengan cara menambahkan satu titik pada graf lingkaran Tujuan dari penelitian ini adalah untuk mengetahui cara menentukan sifat-sifat matriks ketetanggaan pada graf roda, juga untuk mengetahui sifat-sifat matriks ketetanggaan pada graf roda. Selanjutnya untuk menentukan sifat-sifat matriks ketetanggaan pada graf roda dimulai dari mendeskripsikan matriks ketetanggaan dari graf roda , mencari dan mengamati nilai determinan, invers, nilai eigen dan vektor eigen. Determinan matriks ketetanggaan pada graf roda yaitu: untuk graf roda dimana dan maka ; dan maka ; dan maka . Nilai invers matriks ketetanggaan pada graf roda yaitu untuk graf roda dimana tidak memiliki invers, untuk graf roda dimana dan dan memiliki invers. Entri-entri diagonal utama matriks yang didiagonalisasi sama dengan nilai eigennya dan jumlah entri diagonal utamanya atau trace adalah nol.
House dust mite sublingual allergen immunotherapy tablet is safe and well-tolerated in Dutch clinical practice
Authors: Tempels-Pavlica Žana , Aarts Mark C. J. , Welsing Paco M. J. , van der Meer Akke-Nynke , van der Zwan Leonard P. , Uss Elena , Knulst André C. 
Published: February 2024

BackgroundHalf (49%) of clinically diagnosed allergic rhinitis (AR) patients are sensitized to house dust mite (HDM). If allergen avoidance and symptomatic medication fail, allergen immunotherapy may be indicated.ObjectiveWe investigated safety and tolerability of HDM-sublingual immunotherapy by HDM-SLIT tablets in Dutch daily clinical practice.MethodsDaily intake of 12 SQ-HDM SLIT-tablet was investigated in a prospective, multicenter, observational study (EUPAS43753). It comprised 4 consultations in 1 year. Data on safety, tolerability, treatment satisfaction, symptomatic medication, compliance, and clinical effectiveness (Control of Allergic Rhinitis and Asthma Test; CARAT) were collected. Descriptive and longitudinal regression data analysis were performed.ResultsAdult patients (n = 415), mean (SD) age 36.6 (12.2) years, 61.4% female and 36% asthmatic were included. The preponderance (65.1%) experienced adverse events (AEs). These, mostly mild (67%), AEs comprised: oral allergic reactions (58.6%), respiratory (12.4%) and gastrointestinal symptoms (9.4%). Sixty (14.5%) patients stopped due to AEs and 76 (18.3%) for non-AE reasons. CARAT scores improved clinically significant by 6 points and symptomatic medication use decreased from 96.1% to 77.4%. Most patients (74.5%) tolerated the treatment and were compliant (&gt;86.5%). The majority of patients (62.4%) and investigators (69.4%) were satisfied with treatment.ConclusionsHDM SLIT-tablet is a safe and well-tolerated AR treatment. AEs occur often but are mostly mild and decreasing during the first year. CARAT scores improved and symptomatic medication use decreased suggesting better control of AR with treatment. Compliance, tolerability, and treatment satisfaction are good. However, patient follow-up and compliance remain important points of attention when initiating treatment.
Multi-omic analysis of precocious puberty girls: pathway changes and metabolite validation
Authors: Zhou Fang , Mao Jianhong , Jin Zhenzhen , Zhu Li , Li Xiaofang 
Published: February 2024

ObjectivePrecocious puberty (PP) is a prevalent endocrine disorder affecting the physical and mental wellbeing of children. Identifying the triggering factors of PP has become a central issue. This study seeks to investigate the metabolomic and transcriptomic alterations in PP.Material and methodsFirst, 37 school-aged girls diagnosed with PP and 25 age-matched prepubertal control girls were recruited, and the fecal samples were collected for non-targeted metabolomic analysis to screen for differentially expressed metabolites (DEMs). Subsequently, an animal model of PP was constructed by danazol administration to neonatal female rats, and both fecal non-targeted metabolomics and serum next-generation transcriptomic sequencing were performed to screen DEMs and differentially expressed genes (DEGs) in PP. Moreover, the DEM co-existing in clinical and animal models was administrated to PP rats to explore the role of the target metabolite in PP.ResultsA total of 24 DEMs in PP clinical samples and 180 DEMs and 425 DEGs in PP animal samples were identified. The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis showed that these DEMs and DEGs were enriched in disease-associated pathways, including fatty acid synthesis, glycerolipid metabolism, pyrimidine metabolism, steroid hormone biosynthesis, progesterone-mediated oocyte maturation, and gonadotropin-releasing hormone (GnRH) signaling pathway, forming a tight DEM–DEG pathway regulatory network. Further DEM validation demonstrated that thymine supplementation delayed the opening of the vagina and development of PP in model rats.ConclusionThis study reveals that the metabolomic and transcriptomic changes, along with enriched pathways, are implicated in PP based on clinical and animal analyses. The findings may provide new strategies and research avenues for PP treatment.
The impact of health volunteering of radiology students on improving their self-skills and practical capabilities in the Kingdom of Saudi Arabia
Authors: Alzain Amel F. , Elhussein Nagwan , Hamd Zuhal Y. , Fadulelmulla Ibtisam Abdallah , Omer Awatif M. , Alotaibi Ahoud , Alsuhaymi Amani , Aljohany Maram , Alharbi Najwa , Ahmed Amna Mohamed , Hussien Rehab , Elamin Badria Awad , Mohamed Ahmed Medani Afaf , Khandaker Mayeen Uddin 
Published: February 2024

BackgroundVolunteering is a beneficial activity with a wide range of positive outcomes, from the individual to the communal level. In many ways, volunteering has a positive impact on the development of a volunteer’s personality and experience. This study aimed to evaluate the impact of health volunteering on improving the self-skills and practical capacities of students in the western region of the Kingdom of Saudi Arabia.Materials and methodsThe study was a descriptive cross-sectional electronic web-based survey that was submitted on a web-based questionnaire; 183 students answered the survey, and then, the data were analyzed using SPSS.ResultsThis study shows that 95.6% of participants agree and strongly agree that the health volunteering experience was useful, 2.7% of the participants neither agree nor disagree, and 1.6% disagree and strongly disagree. Regarding the distribution of the participants on skills learned from volunteering experience, the largest proportion of student (36.1%) volunteers in the health sector acquired communication skills and the smallest proportion of student (14.8%) volunteers in the acquired time management skills. Regarding the disadvantages, 81.4% of the participants do not think there were any disadvantages to their previous health volunteering experience, while only 18.6% of them think there were any disadvantages to their previous health volunteering experience. Additionally, the study found that the type of the sector affects the skills acquired from health volunteering.ConclusionResearch revealed that the majority considered volunteering a great experience. Volunteering increased the self-skills and practical capacities of radiology students, which proved the hypothesis.
The causality between gut microbiome and chronic regional pain: a Mendelian randomization analysis
Authors: Xiao Qing-Ao , Qin Lei , Yu Jing , Hu Yin-Tao , Ai Lin-Feng , Wang De-Cheng , Xia Xuan , Zhang Xiao-Lin 
Published: February 2024

BackgroundNumerous investigations have underscored the causal effect between chronic pain (CP) and gut microbiota, jointly contributing to the onset and development of widespread CP. Nonetheless, there was still uncertainty about the causal effect between gut microbiota and chronic regional pain (CRP).MethodsGenome-wide association study (GWAS) summary data of gut microbial taxa (MiBioGen Consortium: 211 microbiotas and the Dutch Microbiome Project: 207 microbiotas) and eight types of CRP were used to reveal the causal effect between persistent pain in a specific region of the body and gut microbiota. A two-sample bidirectional Mendelian randomization (MR) design was used. In order to ensure the accuracy of the results, multiple sensitivity analyses were employed.ResultsThis study uncovered significant causal associations between six gut microbial taxa and three types of CRP (forward: Genus Parabacteroides for general pain; Class Bacteroidia, Order Bacteroidales, and Phylum Bacteroidetes for back pain. Reverse: knee pain for Genus Howardella and Order Coriobacteriales) by forward and reverse MR analysis. These findings had been verified by a rigorous Bonferroni correction. Furthermore, this research identified 19 microbial taxa that exhibited potential correlations with four types of CRP. There are no significant or potential gut microbiotas that were associated with other types of CRP, including fascial pain, stomach or abdominal pain, and hip pain.ConclusionThis two-sample bidirectional MR analysis unveiled the causality between gut microbial taxa and eight CRP conditions. The findings reveal the interplay between CRP and 6 gut microbiotas while also delineating 19 potential specific microbial taxa corresponding to diverse locations of persistent pain.
Compensatory increase in ipsilesional supplementary motor area and premotor connectivity is associated with greater gait impairments: a personalized fMRI analysis in chronic stroke
Authors: Peng Xiaolong , Srivastava Shraddha , Sutton Falon , Zhang Yongkuan , Badran Bashar W. , Kautz Steven A. 
Published: February 2024

BackgroundBalance and mobility impairments are prevalent post-stroke and a large number of survivors require walking assistance at 6 months post-stroke which diminishes their overall quality of life. Personalized interventions for gait and balance rehabilitation are crucial. Recent evidence indicates that stroke lesions in primary motor pathways, such as corticoreticular pathways (CRP) and corticospinal tract (CST), may lead to reliance on alternate motor pathways as compensation, but the current evidence lacks comprehensive knowledge about the underlying neural mechanisms.MethodsIn this study, we investigate the functional connectivity (FC) changes within the motor network derived from an individualized cortical parcellation approach in 33 participants with chronic stroke compared to 17 healthy controls. The correlations between altered motor FC and gait deficits (i.e., walking speed and walking balance) were then estimated in the stroke population to understand the compensation mechanism of the motor network in motor function rehabilitation post-stroke.ResultsOur results demonstrated significant FC increases between ipsilesional medial supplementary motor area (SMA) and premotor in stroke compared to healthy controls. Furthermore, we also revealed a negative correlation between ipsilesional SMA-premotor FC and self-selected walking speed, as well as the Functional Gait Assessment (FGA) scores.ConclusionThe increased FC between the ipsilesional SMA and premotor regions could be a compensatory mechanism within the motor network following a stroke when the individual can presumably no longer rely on the more precise CST modulation of movements to produce a healthy walking pattern. These findings enhance our understanding of individualized motor network FC changes and their connection to gait and walking balance impairments post-stroke, improving stroke rehabilitation interventions.