bluuebunny/crossref_metadata_2025_split huggingface dataset:
Geopolitical risk and global green bond market growth
Authors: Mertzanis Charilaos , Tebourbi Imen 
Published: March 2024

AbstractUsing individual transaction data, we investigate how geopolitical risk influences green bond issuance across 73 countries during 2008–2021. We consider deal characteristics, as well as economic and institutional factors. We find a positive association between geopolitical risk and green bond issuance. The effect shows nonlinearity and time delays. Our findings remain robust after conducting sensitivity and endogeneity analysis. After decomposing the geopolitical risk index, we discover that all its components have positive correlations with green bond issuance. Lastly, our study highlights the crucial role of the underwriters' network and specific geopolitical jurisdictions as drivers for global green bond market expansion.
Meta heuristic approaches for sentiment analysis
Authors: Rani Meesala Shobha , Subramanian Sumathy 
Published: March 2024

AbstractOn the Internet, online microblogging and social networks have experienced tremendous growth. Millions of individuals share opinions on social networking platforms including Twitter, Facebook, YouTube, and Microblogging sites. Millions of individuals express their thoughts on social platforms namely Twitter, Facebook, YouTube, and microblogging sites. As user‐generated content is growing to a huge extent on the internet, the analysis, extraction identification and classification of opinion and sentiment polarity of different aspects has now become a challenging issue in sentiment analysis. In sentiment analysis, aspect level opinion mining, opinion spam review detection, extraction and representation of most relevant accessed data from the user‐generated data is a difficult process. The word vector representation using existing deep learning techniques affects the performance in aspect level opinion mining. Spammers propagate false opinion for payment exchange, which leads to degradation of the financial growth, business, and fame of the organization. To overcome the limitations aspect level opinion mining is used to recognize sentiment and polarity of aspects in the specified text. This work presents various input feature vectors of deep learning approaches aiming to improve performance in aspect level opinion mining. Next, three meta‐heuristic algorithms with k‐means clustering approach for classification of opinion spam reviews on social media transit tweets is presented. The proposed approaches are evaluated and compared with other existing approaches as well as other benchmark datasets namely Restaurant and Amazon reviews.
Doing gender in death care: How women are finding their place in Italian funeral directing services
Authors: Grandi Annalisa , Guidetti Gloria , Converso Daniela , Bosco Nicoletta , Colombo Lara 
Published: March 2024

AbstractGendered norms in society can strongly influence the presence of men or women in professional contexts. This study examined the perceptions of 13 women working in the funeral directing services in order to better understand how they perform gender roles to play in a field that has long been considered male‐dominated. The findings suggest that women face many challenges to play a professional role in funeral directing and that they rely on their ability to perform care work to be recognized as better professionals. The issue of physical strength—a characteristic element of funeral work—seems to be an issue that still arouses contrasting positions among women. Another finding was that women also perform gender roles through their professional appearance, which they recognize as an important aspect of their professionalism. This work brings new insight into this specific and under‐researched area and provides new understanding on how women use gender performativity to achieve professionalism in the death care; in particular, it shows that women do gender in different ways to achieve the same entitlement to be good funeral professionals as men.
Relationship Between Tectonic Lineaments and Springs North of Avanos (Central Anatolia, Turkey)
Authors: Demircioğlu Ramazan 
Published: March 2024

AbstractThe study area covers Avanos‐Ozkonak and its surroundings north of Nevsehir province. An attempt was made to determine the relationship between tectonic lineaments and springs in the area. It was found that there is a close relationship between the location of springs and tectonic lineaments. In recent years, lineaments have been used in mineral exploration studies and geothermal areas. Remote sensing methods have also been used in this study. The relationship between tectonic lineaments (faults and fractures) and spring formations obtained from field studies and satellite‐based studies was evaluated. Metamorphic rocks belonging to the Kirsehir massif and Paleocene–Middle Eocene aged units were subjected to polyphase deformation. As a result of these deformations, faults and cracks were formed. This situation has given aquifer properties to the rocks. At the same time, many springs were formed by faults and cracks. This study determined the relationship between 342 springs identified during field works and tectonic lineaments. Approximately 89% of the springs identified in the field were found to be located on the tectonic lineaments obtained from the satellite imagery. Some springs discharged from discontinuities on the formation boundaries.
Haemophilia care in Asia: Learning from clinical practice in some Asian countries
Authors: Angchaisuksiri Pantep , Amurao‐Abiera Marilou , Chou Sheng‐Chien , Chewcharat Pol , Chozie Novie Amelia , Gomez Roy , Leng Tien Sim , Lin Pei‐Chin , Mai Nguyen Thi , Muda Zulaiha , Seth Tulika , Sosothikul Darintr , Siu‐Ming Wong Raymond 
Published: March 2024

AbstractBackgroundThe healthcare systems in Asia vary greatly due to the socio‐economic and cultural diversities which impact haemophilia management.MethodsAn advisory board meeting was conducted with experts in haemophilia care from Asia to understand the heterogeneity in clinical practices and care provision in the region.FindingsThe overall prevalence of haemophilia in Asia ranges between 3 and 8.58/100,000 patients. Haemophilia A was more prevalent as compared to haemophilia B with a ratio of around 5:1. There is under‐diagnosis in the region due to lack of diagnosis, registries and/or lack of appropriate facilities in suburban areas. Most patients are referred to the haematologists by their families or primary care physicians, while some are identified during bleeding episodes. Genetic testing faces obstacles like resource constraints, services available at limited centres and unwillingness of patients to participate. Prophylaxis is offered for people with haemophilia (PWH) with a severe bleeding phenotype. Recombinant factors are approved in most countries across the region and are the preferred therapy. The challenges highlighted for not receiving a high standard of care include patients’ reluctance to use an intravenous treatment, poor patient compliance due to frequency of infusions, budget constraints and lack of funding, insurance, availability and accessibility of factor concentrates. Prevalence of neutralizing antibodies ranged from 5% to 20% in the region. Use of immune tolerance induction and bypassing agents to treat inhibitors depends on their cost and availability.ConclusionHaemophilia care in Asia has evolved to a great extent. However, some challenges remain for which a strategic approach along with multi‐stakeholder involvement are needed.
The effect of preoperative oral hygiene on postoperative infections after cystectomy and urethroplasty—A quasi‐experimental study
Authors: Bavnhøj Linnea Samsø , Pedersen Beritt Bach , Jensen Henriette , Jørgensen Lone , Bruun Niels Henrik , Sander Lotte 
Published: March 2024

AbstractResearch has demonstrated that systematic preoperative oral hygiene reduces nosocomial infections after elective thoracic surgery. However, the impact of preoperative oral hygiene on patients undergoing urologic procedures is unknown. Therefore, the aim of this study was to investigate the effects of systematic preoperative oral hygiene on prescriptions with antibiotics following cystectomy or urethroplasty. A quasi‐experimental study design included all patients undergoing elective radical cystectomy or urethroplasty from 1 January 2018 to 31 May 2021. Patients undergoing cystectomy or urethroplasty were grouped into a prospective intervention group and a retrospective control group. Patients in the intervention group were admitted from 1 January 2020 to 31 May 2021, and were recommended to brush their teeth and rinse their mouths with chlorhexidine gluconate 0.12% four times a day starting 2 days before surgery and continuing until the morning of the operation. Patients admitted from 1 January 2018 to 31 December 2019 received no oral hygiene recommendations and were used as a retrospective control group. Data on oral hygiene performance were self‐reported and collected at admission and data on prescription of antibiotics were collected through the patients' records. The relative risk was calculated to report the effect of the intervention. In total, 39 patients with cystectomy were in the intervention group, whereas 31 were in the control group. For patients having urethroplasty, 27 were in the intervention group and 98 were in the control group. The effect of oral hygiene on the prescription of antibiotics for patients who completely adhered to the oral hygiene recommendations showed a relative risk of 0.554 (95% CI 0.333–0.921) p = 0.02 for cystectomy and 0.825 (95% 0.308–2.209) p = 0.70 for urethroplasty. This study showed a statistically significant reduction in the prescription of antibiotics following oral hygiene recommendations for patients undergoing cystectomy. However, no statistically significant effect was demonstrated for patients undergoing urethroplasty. Despite this result, it seems important to be aware of oral hygiene in patients undergoing surgery to potentially reduce the number of infections and the use of antibiotics because of the antimicrobial resistance that the healthcare system faces.
Effect of prophylactic use of cefazolin in caesarean section on postoperative infection: A meta‐analysis
Authors: Lv Xiangyang , Ren Xiaoshuang , Xu Jiqun , Wu Haicui 
Published: March 2024

AbstractCaesarean section rate is increasing and postoperative wound infection is a major health‐threatening complication after caesarean section (CS). The aim of this study was to evaluate the efficacy of Cefazolin at different time for post‐caesarean delivery. The aim of this study was to compare the use of Cefazolin at different times on infections after CS. The time of antibiotic use in CS can be divided into two groups: before skin incision (SI) and after cord clamping (CC). In this study, 268 relevant articles were found in the database, and finally, 10 articles were analysed. This study included a total of 5256 cases of caesarean section. The data on wound infections, endometritis, urinary tract infections and fever were analysed. Perform an analysis of the data using RevMan 5.3. The results showed that cefazolin before SI reduced wound infection compared to after CC (odds ratio [OR], 0.51; 95% CI: 0.37–0.69; p < 0.0001). Cefazolin prophylactically used before SI reduce endometritis after CS compared to after CC (OR, 0.52; 95% CI: 0.35–0.77; p = 0.001). There was no significant difference in urinary tract infections after CS between cefazolin prophylactically used before SI and after CC (OR, 0.80; 95% CI: 0.50–11.28; p = 0.35). There was no significant difference in fever after CS between the prophylactic use of cefazolin before SI and after CC (OR, 0.60; 95% CI: 0.26–11.43; p = 0.225). Cefazolin before SI reduces wound infection and endometritis after CS.
Topical oxygen therapy and singlet oxygen in wound healing: A scoping review
Authors: Sýkorová Martina , Moffatt Christine Joy , Stentiford Neil , Burian Ewa Anna , Katsuhiro Sasagaki , Wei Yang 
Published: March 2024

AbstractThe aim of this scoping review was to provide an overview of current research into topical oxygen therapies including the under‐researched singlet oxygen for wound healing. A scoping review was undertaken using five databases. After duplicates and ineligible studies were excluded, 49 studies were included for a narrative review. Out of the included 49 studies, 45 (91.8%) were published in the past 10 years (2013–2023) with 32 (65.3%) published in the past 5 years (2018–2023). Eight of the studies were systematic reviews and/or meta‐analysis and 18 were RCTs. The search identified zero human RCTs on singlet oxygen, but one human cohort study and five studies in animals. There is evidence that topical oxygen therapy may be useful for the treatment of chronic wounds, mainly diabetic foot ulcers. Singlet oxygen has shown potential, but would need further confirmation in controlled human trials, including more research to understand the bio‐properties.
Self‐determination in older patients: Experiences from nurse‐dominated ambulance services
Authors: Holmberg Bodil , Svensson Anders , Helge Adam , Bremer Anders 
Published: March 2024

AbstractAimTo describe ambulance clinicians' experiences of self‐determination in older patients.DesignThe study had an inductive and explorative design, guided from a life‐world perspective.MethodsThirty‐two Swedish ambulance clinicians were interviewed in six focus groups in November 2019. The data were analysed with content analysis, developing manifest categories and latent themes.FindingsThe ambulance clinicians assessed the older patients' exercise of self‐determination by engaging in conversation and by being visually alert, to eventually gain an overall picture of their decision‐making capacity. This assessment was used as a platform when informing older patients of their rights, thus promoting their participation in care. Having limited time and narrow guidelines counteracted ambulance clinicians' ambitions to support older patients' general desire to avoid hospitalization, which resulted in an urge to displace their responsibility to external decision‐makers.ConclusionExpectations that older patients with impaired decision‐making ability will give homogeneous responses mean an increased risk of ageist attitudes with a simplified view of patient autonomy. Such attitudes risk the withholding of information about options that healthcare professionals do not wish older patients to choose. When decision‐making is difficult, requests for expanded guidelines may paradoxically risk alienation from the professional nursing role.Implications and ImpactThe findings show ambulance clinicians' unwillingness to shoulder their professional responsibility when encountering older patients with impaired decision‐making ability. In assuming that all older patients reason in the same way, ambulance clinicians tend to adopt a simplistic and somewhat ageist approach when it comes to patient autonomy. This points to deficiencies in ethical competence, which is why increased ethics support is deemed suitable to promote and develop ethical competence. Such support can increase the ability to act as autonomous professionals in accordance with professional ethical codes.Reporting MethodThis study adhered to COREQ guidelines.Patient and Public ContributionNone.
Causal effect of gut microbiota on pancreatic cancer: A Mendelian randomization and colocalization study
Authors: Li Xin , Liang Zhihai 
Published: March 2024

AbstractThe causal relationship between gut microbiota (GM) and pancreatic cancer (PC) remains unclear. This study aimed to investigate the potential genes underlying this mechanism. GM Genome‐wide association study (GWAS) summary data were from the MiBioGen consortium. PC GWAS data were from the National Human Genome Research Institute‐European Bioinformatics Institute (NHGRI‐EBI) GWAS Catalogue. To detect the causal relationship between GM and PC, we implemented three complementary Mendelian randomization (MR) methods: Inverse Variance Weighting (IVW), MR‐Egger and Weighted Median, followed by sensitivity analyses. Furthermore, we integrated GM GWAS data with blood cis‐expression quantitative trait loci (eQTLs) and blood cis‐DNA methylation QTL (mQTLs) using Summary data‐based Mendelian Randomization (SMR) methods. This integration aimed to prioritize potential GM‐affecting genes through SMR analysis of two molecular traits. PC cis‐eQTLs and cis‐mQTLs were summarized from The Cancer Genome Atlas (TCGA) data. Through colocalization analysis of GM cis‐QTLs and PC cis‐QTLs data, we identified common genes that influence both GM and PC. Our study found a causal association between GM and PC, including four protective and five risk‐associated GM [Inverse Variance Weighted (IVW), p < 0.05]. No significant heterogeneity of instrumental variables (IVs) or horizontal pleiotropy was found. The gene SVBP was identified as a GM‐affecting gene using SMR analysis of two molecular traits (FDR<0.05, P_HEIDI>0.05). Additionally, two genes, MCM6 and RPS26, were implicated in the interaction between GM and PC based on colocalization analysis (PPH4>0.5). In summary, this study provides evidence for future research aimed at developing suitable therapeutic interventions and disease prevention.
Identification of important genes related to anoikis in acute myocardial infarction
Authors: Song Puwei , Yakufujiang Yasen , Zhou Jianghui , Gu Shaorui , Wang Wenli , Huo Zhengyuan 
Published: March 2024

AbstractAcute myocardial infarction (AMI) increasingly precipitates severe heart failure, with diagnoses now extending to progressively younger demographics. The focus of this study was to pinpoint critical genes linked to both AMI and anoikis, thereby unveiling potential novel biomarkers for AMI detection and intervention. Differential analysis was performed to identify significant differences in expression, and gene functionality was explored. Weighted gene coexpression network analysis (WGCNA) was used to construct gene coexpression networks. Immunoinfiltration analysis quantified immune cell abundance. Protein–protein interaction (PPI) analysis identified the proteins that interact with theanoikis. MCODE identified key functional modules. Drug enrichment analysis identified relevant compounds explored in the DsigDB. Through WGCNA, 13 key genes associated with anoikis and differentially expressed genes were identified. GO and KEGG pathway enrichment revealed the regulation of apoptotic signalling pathways and negative regulation of anoikis. PPI network analysis was also conducted, and 10 hub genes, such as IL1B, ZAP70, LCK, FASLG, CD4, LRP1, CDH2, MERTK, APOE and VTN were identified. IL1B were correlated with macrophages, mast cells, neutrophils and Tcells in MI, and the most common predicted medications were roxithromycin, NSC267099 and alsterpaullone. This study identified key genes associated with AMI and anoikis, highlighting their role in immune infiltration, diagnosis and medication prediction. These findings provide valuable insights into potential biomarkers and therapeutic targets for AMI.
Childhood and adolescence outcomes in offspring to parents with bipolar disorder: the impact of lifetime parental comorbidity, parental sex, and bipolar subtype
Authors: Takami Lageborn Christine , Zhou Mengping , Boman Marcus , Sjölander Arvid , Larsson Henrik , D'Onofrio Brian M. , Pettersson Erik , Lichtenstein Paul , Landén Mikael 
Published: March 2024

BackgroundOffspring of parents with bipolar disorder have increased risks of their own psychopathology. However, a large‐scale survey of psychiatric, somatic, and adverse social outcomes up to adulthood, which could aid in prioritizing and tailoring prevention, is lacking. It also remains to clarify how risks are modified by other parental factors.MethodsSwedish population registers were linked to compare offspring having (N = 24,788) and not having (N = 247,880) a parent with bipolar disorder with respect to psychiatric diagnoses and psychotropic medication, birth‐related and somatic conditions, social outcomes, accidents, suicide attempts, and mortality. Individuals were followed until age 18. We estimated the influence of lifetime parental psychiatric comorbidity, bipolar disorder subtype, and sex on outcomes.ResultsChildren of parents with bipolar disorder had 2–3 times higher risks of all psychiatric diagnoses, except for bipolar disorder, for which the risk was 11‐fold. Significantly increased risks were also found for several somatic conditions, low school grades, criminal behavior, victimization, accidents, and suicidal behavior. Adjusting for lifetime parental psychiatric comorbidity attenuated most associations. Offspring of a parent with bipolar disorder type 2 had statistically significantly higher risks of attention deficit hyperactivity disorder, respiratory tract conditions, and accidents compared with offspring of a parent with bipolar disorder type 1. Offspring of mothers with bipolar disorder had higher risks of several psychiatric diagnoses, respiratory tract conditions, low school grades, and accidents compared with offspring of fathers with bipolar disorder. Having two parents with bipolar disorder entailed the highest risks of psychiatric outcomes in offspring.ConclusionsEarly intervention and family support are particularly warranted for the offspring of a parent with bipolar disorder in the presence of lifetime parental psychiatric comorbidity, when the parent has bipolar disorder type 2, or when the mother or both parents have bipolar disorder.
Personal, financial and time burden in inherited ichthyoses: A survey of 144 patients in a university‐based setting
Authors: Klein C. , Oji V. , Sommer R. , Augustin M. , Ständer S. , Salzmann S. , Kiekbusch K. , Bodes J. , Danzer M. F. , Traupe H. , Fischer J. , Steinke S. , Süßmuth K. 
Published: March 2024

AbstractBackgroundPatients with inherited ichthyosis suffer from scaling due to mutations affecting the epidermal barrier. Symptomatic treatment with ointments, bathing and mechanical scale removal can alleviate the disease, but therapy is time and cost intensive.ObjectivesWe investigated costs, time and disease burden of ichthyoses. The study addresses difficulties of the healthcare situation for patients with ichthyoses and reveals potential improvements.Materials and MethodsWe developed a questionnaire addressing time and financial effort for the treatment. Additionally, we collected data of the Dermatology Life Quality Index (DLQI) and the Pruritus Life Quality (5PLQ) questionnaires to determine the impact of ichthyosis and associated pruritus on quality of life (QoL).ResultsWe recruited 144 patients with ichthyosis (median age: 23; 53.5% female) from the Department of Dermatology in Muenster (Germany) and the German patient support group including common, rare and syndromic subtypes. Eighty‐seven percent reported applying topical therapeutics at least once per day, 66.4% several times with an overall median duration of 15 min. Highest single expenditure of time was due to balneotherapy (n = 115; median bathing time: 40 min). In 81.9%, the health insurance did not completely cover the costs for topical treatment causing additional financial burden to the patient with a median of 71 € per quarter, herein creams being the largest cost factor (50 €). Patients with Netherton syndrome showed the highest median expenditure (170 €). The QoL impairment under treatment was moderate (median DLQI: 8.5 points). Pruritus was prevalent in 79.9% and showed a distinct impact on QoL (median 5PLQ: 7.5 points) without any significant difference between the subtypes (p = 0.37).ConclusionPatients suffering from ichthyoses have a large and lifelong overall burden in mild and severe subtypes. Since continuous topical treatment is required, financial and psychosocial support needs to be considered beyond dermatological care.