bluuebunny/crossref_metadata_2025_split huggingface dataset:
The predictive value of contrast-enhanced ultrasound combined with ultrasonic elastography in response to neoadjuvant chemotherapy in different molecular types of breast cancer
Authors: Wang Yanjuan , Jiao Huajie , Han Tao , Yang Guangfei , Ke Qinglan , Zhang Qian , Wang Fuxia 
Published: April 2024

Abstract

Objective: To investigate the predictive efficacy of contrast-enhanced ultrasound (CEUS) and elastosonography (ELA) in adjuvant chemotherapy in patients with different molecular types of breast cancer.
Methods: 74 patients with breast cancer from June 2021 to August 2023 were divided into Luminal A group, Luminal B group and human epidermal growth factor receptor 2 (HER-2) group according to molecular typing. All patients underwent neoadjuvant chemotherapy treatment and were divided into a reactive group (n=61 cases) and a non reactive group (n=13 cases) based on the treatment effect. All patients underwent contrast-enhanced ultrasound and ultrasound elastography (using shear wave elastography (SWE) mode) examination, and ROC curves were plotted to analyze the combined predictive performance of contrast-enhanced ultrasound and ultrasound elastography.
Result: There was no statistically significant difference in the parameters of contrast-enhanced ultrasound and ultrasound elastography between the Luminal A group, Luminal B group, and HER-2 group (P>0.05); The parameters of contrast-enhanced ultrasound and ultrasound elastography after chemotherapy in breast cancer with different molecular types were lower than those before chemotherapy (P<0.05); Among 74 patients with breast cancer, 13 (17.57%) were non responsive to neoadjuvant chemotherapy. The PT, K1, and SR of the non reactive group were higher than those of the reactive group (P<0.05); The ROC curve results showed that the combined examination of contrast-enhanced ultrasound and ultrasonic elastography was more effective than the single examination in predicting the response to neoadjuvant chemotherapy in patients with different molecular types of breast cancer (P<0.05).
Conclusion: When breast cancer patients are treated with neoadjuvant chemotherapy under different molecular classifications, the indexes of contrast-enhanced ultrasound and elastography have changed before and after chemotherapy, and the combination of the two has a high predictive value for different molecular classifications of breast cancer, which can obtain high sensitivity and specificity, and can provide a reliable basis for the formulation and adjustment of adjuvant therapy programs.
Dynamic Analysis of Pre-Stressed Concrete Girder Bridge Using Csibridge Software
Authors: Das Soumya Suhreed , Das Joyonta Chandra , Rahman Md. Sifur 
Published: April 2024

Abstract

Bridges are crucial transportation components that must be able to withstand seismic events to ensure public safety. Prestressed concrete bridges are commonly used, but their behavior under seismic loading conditions needs to be thoroughly studied. The research intends to investigate how bridges respond to seismic activity by utilizing the powerful FEM tool known as CSiBridge software, and aims to improve design methods and guidelines, enhance performance, and identify potential vulnerabilities and failure modes during earthquakes. As a result, a detailed design of a prestressed concrete bridge model was developed and examined throughout this study. The bridge under study has three 90 feet spans with a total width of 35 feet with four AASHTO-PCI BT-63 bulb-tee Precast Beams on thick cast-in-place. concrete deck Abutments are positioned at each end of the bridge. Verification of bridge superstructure components using the AASHTO LRFD code reference and the bridge modeling process using verified components through CSiBridge software was completed. Detail seismic design, including modal, pushover, and response spectrum analyses, was prepared for conduction on the model. Analyzing the entire model, including construction, materials, properties, and location-specific seismic conditions, constitutes the final step.
Evaluation of the relationship between time management and professional self-efficacy with quality of nursing care in nurses of northwest Iran
Authors: KhalilzadehZia Sana , Mohamadi MohammadAli , Zadeh Mehdi Mahmoud , Dadkhah Behrouz 
Published: April 2024

Abstract

Aims The present study aims to evaluate the relationship between time management and professional self-efficacy with the quality of nursing care in nurses of northwest Iran.Background Nowadays time is a vital factor in medical interventions. Time management and self-efficacy are crucial for retrieving the best nursing care standards.Methods This correlational study was conducted in Ardabil, northwest of Iran, in 2023. In these 350 nurses have been categorized by stratified sampling method. For data collection, we used Raj’a Nayef Zyoud's(2023) time management inventory, Masoumeh Bakhtiari et al(2023) professional self-efficacy of nurses inventory, and Anita Karaca et al(2022) nursing care quality inventory. The collected data were analyzed in SPSS software (26) using descriptive statistics, independent t-test, analysis of variance, Pearson correlation coefficients, and linear regression stepwise model.Result The results revealed that Time management (80.3%), Professional Self-efficacy (61.7%), and Quality of nursing care (57.1%) were at a moderate level. Also, the mean value of the time management score, professional self-efficacy score, and nursing care quality score were (59.79 ± 10.37), (72.64 ± 12.34), and (45.151 ± 16.78), respectively. There was a meaningful relationship between time management and professional self-efficacy with the quality of nursing care (p < 0.001). The stepwise multiple linear regression model showed that time management (65%) was a stronger predictor than professional self-efficacy (62%) on the quality of nursing care.Conclusion contributing nurses in this study had shown a medium level of nursing care. We suggest that medical politicians conduct workshops to upgrade time management skills and the professional self-efficacy of nurses so that the quality of nursing care improves as well.
A study on the privacy dilemma overcoming method of voluntary personal information leakage in relational SNS: data-based privacy leakage risk score development
Authors: Bae Hyunjin , Cha Kyungjin 
Published: April 2024

Abstract

The advancement of internet technology has facilitated the emergence of relational Social Network Services (SNS), offering services based on individuals' social connections. SNS users utilize personal information as a means of self-expression, thereby constructing their own social networks. However, the proliferation of personal information breaches has emerged as a significant contemporary concern due to the escalating use of SNS platforms. Recent incidents predominantly involve the collection and dissemination of information voluntarily disclosed on SNS, rather than by hacking. Despite the imperative need to forestall such breaches, there is a dearth of empirically applicable methodologies to gauge the risk of personal information leakage. Prior research methodologies for quantitatively assessing breach risk have predominantly concentrated on evaluating personal profiles alone, with limited consideration given to the potential identifiability of personal information embedded within uploaded content. Furthermore, these studies have often relied on surveys to ascertain users' perceptions of personal information leakage risk, hereby constraining their practical applicability and difficult to fulfill the objective of preventing personal information breaches. Hence, this study proposes a method for estimating privacy leakage risk based on the privacy-dilemma framework, which underscores the dilemmas SNS users encounter in managing both personal profiles and content data. Leveraging Social Network Analysis (SNA) to capture the nuances of relational SNS characteristics, we aim to enhance methodologies proposed in previous studies. The Multiple Regression Quadratic Assignment Procedure (MR-QAP) analysis is employed to delineate the factors influencing the risk score. This methodological approach holds promise in furnishing practical insights into privacy protection.
Unlocking the potential of Euglena gracilis cultivated in piggery wastewater: biomass production, nutrient removal, and biostimulant potential in lettuce and tomato plants
Authors: Butzke Valéria Louzada Leal , Ferreira Alice , Corrêa Diego Oliveira , Furlan Júnior Mendes , Gouveia Luisa , Schneider Rosana de Cássia de Souza , Corbellini Valeriano Antonio 
Published: April 2024

Abstract

Microalgae are increasingly recognized as a valuable resource for bolstering sustainability in agriculture. Yet, current research often overlooks the diversity of microalgae species. Euglena gracilis (Euglenophyta) is a microalga renowned for its resilience to diverse environmental stressors and capability to produce a variety of bioactive metabolites. This study investigated the potential of cultivating E. gracilis in piggery wastewater for nutrient recycling and as a source of beneficial biomolecules, particularly for biostimulant use. Utilizing raw wastewater diluted to 25% (P25) and pre-treated wastewater with photo-Fenton (PF), the research found that E. gracilis exhibited elevated cell density, biomass concentration, and overall cell health in both wastewaters compared to a synthetic medium (BG11-NPK). This was due to its efficient removal of nutrients, especially ammoniacal-nitrogen and phosphate, resulting in a biomass rich in polyunsaturated fatty acids, amino acids, and paramylon content. The whole-cell biomass significantly enhanced the germination index of lettuce and tomato seeds compared to the water control. Additionally, it promoted cell expansion and root formation in cucumber cotyledons, exhibiting similarities to phytohormones such as gibberellin, cytokinin, and auxin. Furthermore, it is suggested that E. gracilis biomass contains molecules related to resistance to environmental stresses, particularly in tomatoes, given the enhancement in the seedling vigor index. E. gracilis exhibited remarkable adaptability to piggery wastewater, recycling nutrients and yielding biomass rich in bioactive molecules with potential as plant biostimulants. These findings significantly contribute to understanding E. gracilis's potential applications in agriculture and developing a circular bioeconomy.
High-voltage pulse generator based on LTD concept for CuBr+Ne+HBr laser media excitation
Authors: Semenov Konstantin Yu. , Gembukh Pavel I. , Trigub Maxim V. 
Published: April 2024

Abstract

The paper presents the power supply based on the LTD-generator concept for active elements on metal halide vapors excitation. The main source feature is the modular structure which allow to increase output voltage and change storage capacity due to the number of modules. Each module is designed to minimize parasitic parameters and provide high voltage and current slew rates to the GDT. The limit parameters of one module are as follows: maximum voltage 1100 V, maximum pre-pulse energy in the storage capacity 9.0 mJ. The results of the excitation of the active media at the different pulse repetition frequency are presented. For the first time the 1.5 W radiation power was obtained for the laser excited by this type of power supply.
Psychometric properties of the Arabic Spence Children’s Anxiety Scale- Parent in a non-clinical sample of Arabic-speaking adults
Authors: Milane Mia-Joe , Chahine Abdallah , Malaeb Diana , El-Khatib Sami , Dabbous Mariam , Sakr Fouad , Fekih-Romdhane Feten , Hallit Souheil , Obeid Sahar 
Published: April 2024

Abstract

Background
Anxiety, characterized by an unpleasant state of anticipatory unease, manifests in approximately 19% of adolescents and children within the Lebanese population. The diagnostic challenge in pediatric populations often stems from parental reluctance to acknowledge potential mental health concerns. Various screening instruments, including the Spence Children’s Anxiety Scale (SCAS), aid in identification of anxiety, yielding the necessity of validation of the scale in the Arabic language. This study aims to validate the SCAS-Parent in Lebanon, assessing reliability, validity and consistency of the scale.
Methods
This cross-sectional study enrolled adults parents from all over Lebanon. The data was collected through a Google form and using snowball technique during November 2023. The questionnaire included sociodemographic data, the Brief version of the Spence Children's Anxiety Scale for the Parents (SCAS-P-8) and the Depression Anxiety Stress Scale (DASS-8).
Results
Confirmatory factor analysis indicated that fit of the one-factor model of the SCAS-P-8 scale was acceptable: χ2/df = 84.53/20 = 4.23, RMSEA = 0.080 (90% CI 0.063, 0.098), SRMR = 0.035, CFI = 0.966, TLI = 0.952. The standardized estimates of factor loadings were all adequate. The reliability of the scale was good (ω = 0.90 / α = 0.90). Higher parental depression (r = 0.61; p < 0.001), anxiety (r = 0.62; p < 0.001) and stress (r = 0.48; p < 0.001) were significantly associated with higher anxiety in the child.
Conclusion
The study validates the SCAS-P-8 for its application in the Lebanese population, demonstrating high internal consistency, reliability, and validity, indicating its potential as a screening tool for anxiety in children in the hands of psychologists and health-care professionals. Anxious parents will most likely have anxious children, leading to a viscous cycle. Early screening of anxiety in children can potentially impact the quality of life, life choices and developmental status of children.
Evaluating the quality and nutritional content of bottled waters in Algeria
Authors: Tamrabet Lahbib , Sekiou Fateh , Tamrabet Selsabil 
Published: April 2024

ABSTRACT

The present study offers a quality assessment of the mineral and spring waters marketed in Algeria within the national and international legislations, examine the potential contribution of bottled waters to essential elements intake and effects on public health based on empirical, graphical tools, multivariate statistical techniques and (DRI) system. The study covered a dataset of 30 mineral and 33 spring brands. The parameters included, from bottle labels, were of physicochemical nature. All brands comply with national and WHO norms for the bottled waters, except for (Brand#63) in which NO2− exceeded the maximum permissible limit for mineral water and (Brands#4 and #21) where TH and TDS exceeded the Algerian recommended guidelines for spring water. Nearly 5% of the total brands were of bicarbonate nature belonging to mineral water, while 25% of all brands were suitable for low-sodium-diet. PCA and HCA showed that bottled waters could be classified into two distinct groups, according to degree of mineralization. The DRI-system revealed that Algerian bottled waters contributed substantially to the daily intake for Mg2+ with up to (63%), Na+ (40.36%) and Ca2+ (36%) for spring water for different ages and genders, whereas mineral water exceeded the maximum recommended daily intake for Ca2+ (128%) and Na+ (148.36%) for adults.
Reducing costs of Giardia spp. cyst enumeration using machine learning-based systems
Authors: Belini Valdinei Luís , Fava Natália de Melo Nasser , Sabogal-Paz Lyda Patrícia 
Published: April 2024

Abstract

Giardia spp. cyst enumeration is a laboratory procedure that is frequently required in water treatment-related research. Currently, detection conducted by experts using fluorescence microscopy on samples stained with specific markers for Giardia spp. cysts is still the standard method, despite its high costs limiting its usage worldwide and, ultimately, hindering waterborne analyses in low-income countries. We present an approach based on darkfield imaging and machine learning to reduce costs associated with Giardia spp. cyst enumeration and the lack of experts. Automated counts were compared to manual counts, achieving an average sensitivity (SE) rate of 88%, specificity (SP) of 100% and accuracy of 88% across a wide range of cyst concentrations. By using machine learning in conjunction with darkfield microscopy, a low-cost illumination technique that can be easily integrated into standard laboratory microscopes, we have significantly reduced the costs associated with Giardia spp. cyst detection, all while still maintaining the SE and SP of fluorescence microscopy. Based on the findings, the proposed system has the potential to be a useful tool to enumerate Giardia spp. cyst suspensions. It can be accessed by virtually any microbiology laboratory as it is consumable-free and expert-independent.
Comprehensive evaluation and analysis of water resource characteristics in Lixiahe Plain, China
Authors: He Liang , Yang Liwen , Chen Ling , Ye Yabin , Zhang Shuo , Xu Chenfang 
Published: April 2024

ABSTRACT

Lixiahe Plain's local water resources need to be evaluated effectively and comprehensively. This study is based on the multisource data from 60 natural water samples, 16 rainfall monitoring stations, and 2 evaporation monitoring stations from 1965 to 2020. Synchronous series representativeness analysis, water quality analysis, and water resource availability estimation are conducted to analyze the spatiotemporal distribution characteristics of rainfall, evaporation, and water quality and calculate the availability of various types of water resources. The results indicate that the spatiotemporal distribution of rainfall and evapotranspiration in the study area is uneven, which increases the threat of local floods and droughts. The quality of the main rivers and lakes in the region is good, and the water quality of the drinking water source area and groundwater reaches and even exceeds Class III water standards. In the year 2020, the total water usage in the research area reached 341 million m3. However, the available sum of surface water resources and transit water availability in 2022 was only 201 million m3, so local water supply needs cannot be easily met. Exploring the water resource characterization model of the Lower Rivers Plain can help in local water resource management and protection.
Defluoridation of tap water by electrocoagulation and fluoride adsorption on aluminum hydroxide flocs
Authors: Dhifallah Sirin , Attour Anis , Vial Christophe , Zagrouba Fehti , Audonnet Fabrice 
Published: April 2024

ABSTRACTOverload of fluoride ions in water is observed in several regions of southern Tunisia, mainly the regions close to the mining basin of Gafsa: Metlaoui, Omlarayes and Redayef. This study concerns fluoride removal from Metlaoui's tap water by electrocoagulation (EC) using aluminum electrodes in a batch reactor. This water contains 3.5 mg·L−1 of fluoride, the highest concentration observed in these basins. The effect of the operating conditions of EC treatment on tap water defluoridation was analyzed, namely, current density, temperature and interelectrode distance. Hydroxide aluminum flocs, formed with different durations of EC, were used as sorbents in fluorinated deionized water ([F−] = 3.5 mg·L−1) and Metlaoui's tap water. Flocs formed after 30 min of EC, produced by dissolving (79 ± 1) mg·L−1 of aluminum and adjusted at pH = 6.5, allowed the adsorption of (98 ± 1)% of fluoride ions from deionized fluorinated water. Flocs adjusted at different pH, from 5 to 9, were used as sorbents in fluorinated deionized water and Metlaoui's tap water. Acidic and neutral flocs allowed the best yields of fluoride adsorption. Contrary to the literature, this work highlighted the absence of ion exchange of hydroxide anion by fluoride anion in water, highlighting a mechanism of physical adsorption on aluminum hydroxide flocs.
Enhanced properties of a positive-charged nanofiltration membrane containing quaternarized chitosan through second interfacial polymerization for the removal of salts and pharmaceuticals
Authors: Bai Xinhui , Lu Yuting , Wang Mudan , Yu Xinyang , Huang Zhonghua 
Published: April 2024

ABSTRACT

Nanofiltration (NF) membrane technology has been widely used in the removal of salts and trace organic pollutants, such as pharmaceuticals and personal care products (PPCPs), due to its superiority. A positive-charged composite NF membrane with an active skin layer was prepared by polyethyleneimine (PEI), trimethyl benzene chloride, and quaternate chitosan (HTCC) through second interfacial polymerization on the polyethersulfone ultrafiltration membrane. The physicochemical properties of the nanocomposite membrane were investigated using surface morphology, hydrophilicity, surface charge, and molecular weight cut-off (MWCO). The influence of the concentration and reaction time of PEI and HTCC was documented. The optimized membrane had a MWCO of about 481 Da and possessed a pure water permeability of 25.37 L·m−2·h−1·MPa−1. The results also exhibited salt rejection ability as MgCl2 &gt; CaCl2 &gt; MgSO4 &gt; Na2SO4 &gt; NaCl &gt; KCl, showing a positive charge on the fabricated membrane. In addition, the membrane had higher rejection to atenolol, carbamazepine, amlodipine, and ibuprofen at 89.46, 86.02, 90.12, and 77.21%, respectively. Moreover, the anti-fouling performance and stability of the NF membrane were also improved.
Exploring the Therapeutic Potential of Flavonoids in the Management of Cancer
Authors: Singh Sonia , Verma Riya 
Published: April 2024

:
Flavonoids are a class of polyphenolic compounds that can be classified into six distinct
categories, namely isoflavonoids, flavanones, flavanols, flavonols, flavones, and anthocyanidins.
These compounds are naturally occurring and can be found in a diverse range of plant
species. Flavonoids, a class of bioactive compounds, are mostly obtained through the consumption
of vegetables, fruits and plant-derived beverages such as wine, cocoa-based products and
green tea. Flavonoids have been demonstrated to exhibit a diverse range of anticancer properties.
These include the modulation of activities of enzymes involved in scavenging reactive oxygen
species, involvement in cell cycle arrest, induction of apoptosis and autophagy, as well as suppression
of cancer cell proliferation and invasiveness. Flavonoids exhibit a dual role in maintaining
reactive oxygen species balance. They function as antioxidants in regular physiological conditions,
while also demonstrating significant pro-oxidant properties in cancer cells. This prooxidant
activity induces apoptotic pathways and downregulates pro-inflammatory signalling
pathways. The paper explores the biochemical characteristics, bioavailability, anticancer efficacy,
and modes of action of flavonoids.
Cisplatin-Based Combination Therapy for Enhanced Cancer Treatment
Authors: Li Qi , Chen Siwei , Wang Xiao , Cai Jia , Huang Hongwu , Tang Shengsong , He Dongxiu 
Published: April 2024

Abstract::
Cisplatin, a primary chemotherapeutic drug, is of great value in the realm of tumor treatment.
However, its clinical efficacy is strictly hindered by issues, such as drug resistance, relapse,
poor prognosis, and toxicity to normal tissue. Cisplatin-based combination therapy has garnered increasing
attention in both preclinical and clinical cancer research for its ability to overcome resistance,
reduce toxicity, and enhance anticancer effects. This review examines three primary co-administration
strategies of cisplatin-based drug combinations and their respective advantages and
disadvantages. Additionally, seven types of combination therapies involving cisplatin are discussed,
focusing on their main therapeutic effects, mechanisms in preclinical research, and clinical
applications. This review also discusses future prospects and challenges, aiming to offer guidance
for the development of optimal cisplatin-based combination therapy regimens for improved cancer
treatment.