bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perancangan Sistem Informasi Antrean Pembayaran Pemakaian Air Berbasis Web di PDAM Kabupaten Sumba Timur
Authors: Kanatalo Rexi , Kalaway Rambu Yetti , Abineno Reynaldi Thimotius 
Published: February 2025

Perkembangan ilmu pengetahuan dan teknologi, khususnya di bidang teknologi informasi, memiliki peran penting dalam berbagai sektor, termasuk perusahaan, institusi pendidikan, dan rumah sakit. Sistem informasi kini menjadi aspek utama yang mendukung pengelolaan data dan penyampaian informasi secara efisien. Salah satunya PDAM Kabupaten Sumba Timur adalah salah satu perusahaan daerah yang bergerak di bidang pelayanan penyedia air bersih dimana dalam proses pembayaran air masih melakukan antrean dengan melakukan pengambilan nomor selanjutnya akan mendapatkan pelayanan hal ini mengakibatkan antrean panjang dalam melakukan pembayaran, dan pengaduan. Berdasarkan Observasi yang dilakukan pada PDAM Sumba Timur, terdapat banyak antrean masyarakat dengan tujuan melakukan pembayaran air serta pengaduan terkait pelayanan air. Pada hasil Observasi tersebut Masyarakat dilayani dengan waktu estimasi setiap orang sekitar 4-6 menit tergantung berapa banyak nomor rekening meteran air yang di miliki oleh masyarakat, atau pengaduan dan permasalahan yang dialami oleh masyarakat. Proses ini menyebabkan antrean yang panjang terutama pada saat jam sibuk yang membuat beberapa masyarakat tidak terlayani. Hal ini menyebabkan pelayanan menjadi kurang efektif dan efisien. Oleh karena itu, diperlukan sebuah inovasi untuk memudahkan masyarakat dalam mengakses layanan pembayaran dan pengaduan secara realtime. Dengan adanya sebuah sistem yang dapat diakses dari mana saja, baik di rumah maupun di luar, dengan hanya mengisi data diri dan jenis layanan yang dibutuhkan akan memudahkan masyarakat tanpa harus melakukan antrean. Implementasi sistem antrean online ini diharapkan mampu meningkatkan efisiensi, mengurangi antrean fisik, serta memperbaiki kualitas pelayanan PDAM Kabupaten Sumba Timur. Sistem dikembangkan menggunakan metode Waterfall dengan menerapakan alur yang ada seperti Analisis Kebutuhan, Desain, Implementasi, Pengujian dan Pemeliharaan sehingga sistem yang dikembangkan berjalan dengan baik.
EFFECTIVENESS OF THE BANDUNG COMMAND CENTER NTPD 112 SERVICE PROGRAM (SINGLE NUMBER FOR EMERGENCY CALLS) AT BANDUNG CITY COMMUNICATION AND INFORMATION SERVICE
Authors: Salsabila Salma , Ridwan Muhammad Ridwan 
Published: February 2025

The use of a single Emergency Call Number 112 which is used as a call center method to report emergencies that occur in the city of Bandung is still less effective. This is based on the fact that there are still many prank calls and ghost calls coming to NTPD 112. This research aims to determine the effectiveness of the Bandung Command Center NTPD 112 service program in emergency calls in Bandung City. Where this research applies effectiveness theory based on the views of M Ricard Steers (1985: 8) who believes that measuring effectiveness can be done through 4 (four) barometers: organizational characteristics, environmental characteristics, worker characteristics, policy characteristics and management practices. The method applied in this research is descriptive with a qualitative approach. Based on the research results, it can be concluded that the Bandung Command Center NTPD 112 service program which is linked to four criteria, namely organizational characteristics, environment, workers and characteristics of management policies and practices, is considered not fully effective. The main problems include double jobs in the Dispatcher division, poor coordination with agencies, low performance ties, the lack of achievement of strategic goals and a lack of innovation which resulted in the number of invalid calls in 2024 for the January-July period being 12,129 incoming calls.

Keywords: Effectiveness, Command Center, NTPD 112, Emergency
PEREMPUAN KINASIH’S SOLIDARITY AS POLICY ENTREPRENEURS: INNOVATIVE STRATEGIES IN SUPPORTING WOMEN FARMERS TOWARDS FOOD SOVEREIGNTY
Authors: Dewi Tevana Sari , Qodarsasi Umi 
Published: February 2025

This research analyzes the contribution of the Solidaritas Perempuan (SP) Kinasih Yogyakarta community in encouraging the creation of gender-responsive public policies in the food sector. The method used in this research is descriptive qualitative, which examines various advocacy strategies that have been carried out by SP Kinasih, ranging from community organizing and public education to policy advocacy. The findings show that SP Kinasih has played an important role in influencing public policies at the local and national levels. However, the research also highlights the importance of building broader coalitions and strengthening the capacity of civil society organizations in facing complex challenges.

Keywords: Women's Food Sovereignty, Advocacy Strategy, Public Policy
Additive impact of metabolic syndrome and sarcopenia on all-cause and cause-specific mortality: an analysis of NHANES
Authors: Zhang Meng , Zeng Qing-Yue , Zhuang Linli 
Published: February 2025

BackgroundMetabolic syndrome (MetS) and sarcopenia (SP) are increasingly significant public health issues in aging societies, sharing common pathophysiological mechanisms and being associated with severe health consequences. This study investigates the impact of MetS and SP on all-cause and cause-specific mortality using a longitudinal, nationally representative population-based cohort.MethodsThe study analyzed data from the National Health and Nutrition Examination Survey (NHANES) conducted between 1999 and 2018. Mortality data were obtained from the National Death Index up to December 2019.ResultsAmong the 21,962 participants, 13,517 (61.5%) had neither MetS nor SP(MetS-/SP-), 5,407 (24.6%) had MetS only(MetS+/SP-), 2,698 (12.2%) had SP only(MetS-/SP+), and 340 (1.5%) had both MetS and SP(MetS+/SP+). Compared to the group without MetS and SP, the groups with MetS only, SP only, and both MetS and SP showed increased all-cause mortality, with adjusted hazard ratios (HR) of 1.23 (95% CI: 1.11-1.37), 1.63 (95% CI: 1.41-1.89), and 1.61 (95% CI: 1.33-1.95), respectively. The MetS+/SP+ group had the highest overall mortality risk (trend test p&lt;0.0001). For cause-specific mortality, the MetS+/SP+ group exhibited increased cardiovascular mortality (HR: 1.89, 95% CI: 1.27-2.81), cardiac mortality (HR: 1.89, 95% CI: 1.25-2.86), respiratory mortality (HR: 2.63, 95% CI: 1.29-5.35), and diabetes mortality (HR: 8.79, 95% CI: 2.62-29.45) compared to the group without MetS and SP.ConclusionThe coexistence of MetS and SP significantly increases the risk of all-cause and cause-specific mortality. Individuals with either condition may require more vigilant management to prevent the onset of the other condition, thereby reducing mortality rates. These findings highlight the importance of integrated healthcare strategies targeting both MetS and SP to improve patient outcomes and longevity.
Causal links between obesity, lipids, adipokines, and cognition: a bidirectional Mendelian-randomization analysis
Authors: Gong Meng , Liu Haichao , Liu Zhixiang , Wang Yongshen , Qi Shiyi , Guo Hong , Jin Song 
Published: February 2025

BackgroundThe aim of this study was to explore the genetic level association between obesity, lipids, adipokines, and cognitive ability using bidirectional Mendelian randomization (MR) strategies.MethodsSummary data for three obesity indicators [body mass index (BMI), body fat percentage (BFP) and waist-hip ratio (WHR)], three lipid indicators [HDL cholesterol (HDL), LDL cholesterol (LDL) and triglycerides (TG)], three adipokines [circulating leptin (LEP), Agouti-related protein (AgRP) and Adiponectin (APDN)], and four cognitive ability indicators [cognitive function (CF), cognitive performance (CP), simple reaction time (SRT) and fluid intelligence score (FIS)] were collected. Bidirectional inverse-variance weighted Mendelian randomization (MR) was employed to evaluate the relationship between adiposity and cognitive function. We employed genetic instruments for adiposity indicators as exposures in one direction, and repeated the analysis in the opposite direction using instruments for cognitive function. Sensitivity analyses were conducted to explore heterogeneity and potential horizontal pleiotropy.ResultsGenetically predicted adiposity showed robust associations with markers of cognitive ability. Higher genetically predicted obesity indicators (such as BMI, BFP and WHR), and lipid and adipokineslevels (such as HDL and AgRP) with reduced cognitive ability indicators (such as CF and CP). In the opposite direction, FIS and SRT may influence BMI and HDL respectively. MR estimates for the effects of cognition ability on all obesity, lipids and adipokines measures indicated worse FIS and SRT were associated with higher BMI and lower HDL.ConclusionsOur MR reveals that high BMI, BFP, WHR and AgRP have negative causal direct effects with cognitive ability, while high HDL and ADPN have positive causal direct effects with cognitive ability. For the reverse causal direction, our consistent findings that worse cognitive function such as SRT and FIS may influence serum HDL level and BMI.
SHP2 is essential for the progesterone-promoted proliferation and migration in breast cancer cell lines
Authors: Wang Hui-Chen , Lee Wen-Sen 
Published: February 2025

IntroductionWe previously demonstrated that progesterone (P4) can promote breast cancer cell proliferation and migration through activating the P4 receptor (PR)/cSrc-mediated signaling pathway. It has been suggested that high level of Src homology region 2 domain-containing phosphatase-2 (SHP2) might be involved in breast oncogenesis. This study aimed to investigate whether SHP2 is involved in the P4-mediated cSrc activation in breast cancer cells.MethodsT47D, MCF-7 and BT-483 breast cancer cell lines were used in this study. Cell proliferation and migration were examined using MTT technique and wound healing assay, respectively. Immunoprecipitation assay and Western blot analysis were performed to evaluate protein-protein interaction and protein expression, respectively. Small interfering RNA (siRNA) technique was used to knock down protein expression.ResultsKnockdown of SHP2 expression abolished the P4-promoted cell proliferation and migration in T47D, MCF and BT-483 cell lines, suggesting that presence of SHP2 is essential for the P4-increased proliferation and migration of breast cancer cell lines. P4 (50 nM) treatment increased the complex formations of PR-cSrc-SHP2-caveolin-1, SHP2-p140Cap, and SHP2-Csk, and the level of p-cSrcY416 (activated form of cSrc). However, knockdown of SHP2 expression increased the complex formations of PR-cSrc-caveolin-1-Csk-p140Cap and the levels of p-caveolin-1, p-Csk and p-cSrcY527 (inactivated form of cSrc).DiscussionOur data suggest that SHP2 can bind to cSrc-negative regulatory proteins (p140Cap and Csk), hence preventing the interaction between cSrc and cSrc-negative regulatory proteins, leading to decreased phosphorylation of cSrc Y527 and prolonged cSrc activation. These findings highlight the role of SHP2 in the P4-promoted breast cancer cell proliferation and migration.
Functional analysis of a novel homozygous missense IVD gene variant: a case report with dual genetic diagnoses
Authors: Zhu Yuying , Wu Ke , Wen Hanying 
Published: February 2025

BackgroundGenomic or exome sequencing is beneficial for identifying more than one pathogenic variation causing blended atypical and/or severe phenotypes. Herein, we are the first to report a 5-year-old boy with the blended phenotypes of infantile hypotonia, severe neurodevelopmental disorder, patent ductus arteriosus, cryptorchidism, obesity, distinctive facial features, and elevated isovaleryl carnitine.MethodsTrio-based whole-exome sequencing was performed on genomic DNA from peripheral blood samples from the boy and his parents. Functional analysis of the IVD variant in vitro was performed. Mutant IVD gene pcDNA3.1(+)-MUT-3xFlag and control pcDNA3.1(+)-WT-3xFlag mammalian expression vectors were constructed. Both vectors were transformed into HEK293T cells. The assays of relative IVD gene mRNA expression, IVD protein expression, and enzymatic activity were used.ResultsWhole-exome sequencing identified a novel homozygous missense variant in the IVD gene (NM_002225.5) c.1006T&gt;C (p.Cys336Arg) within a region of homozygosity of 15q11.2-q21.3. Our in vitro functional and computer simulation findings revealed that this variant was associated with haploinsufficiency, which resulted in dramatically reducing the formation of IVD protein due to unstable mutant protein and not a lack of mRNA expression.ConclusionThe boy was diagnosed with the dual genetic disorders of Prader–Willi syndrome and isovaleric acidemia. This case provides a useful reference for genetic counseling for complex and diverse clinical phenotypes. The presence of two or more likely pathogenic or pathogenic variations in an individual with neurodevelopmental phenotypes is not an “exceptional” phenomenon.
Optimizing plant density to improve the soil microenvironment and enhance crop productivity in cotton/cumin intercropping systems
Authors: Zhang Humei , Tian Liwen , Hao Xianzhe , Li Nannan , Shi Xiaojuan , Shi Feng , Tian Yu , Wang Wenbo , Luo Honghai 
Published: February 2025

IntroductionResidual film pollution has become a key factor that affects the sustainable development of cotton, and intercropping may be an economical and environmentally friendly method to reduce the negative effects of nonmulched conditions on cotton growth. We hypothesized that optimizing the cotton/cumin intercropping density would improve the soil environment and increase crop productivity and resource utilization.MethodsTherefore, in this study, singlecropping cotton (CK) was used as the control, and three intercropping cumin seeding densities were used (plants ha-1: 5×105, ID1; 8×105, ID2; and 11×105, ID3). Through a two-year field experiment, the effects of cotton-cumin intercropping on the soil moisture, temperature, salt, respiration rate, weed density, cotton yield formation and intercropping advantages were studied.Results and discussionCompared with the CK treatment, the ID2 treatment decreased the water content in the 0–30 cm soil layer by 8.3%, increased the water consumption by 9.1%, increased the soil temperature by 0.5°C, and decreased the electrical conductivity of the 0–15 cm soil layer by 17.7%. Compared with the CK treatment, the ID1 treatment significantly decreased the soil respiration rate by 33.6%, and the weed density decreased in the following order: CK&gt;ID1&gt;ID2&gt;ID3. During the nonsymbiotic period, compared with CK, ID2 increased the soil water content by 5.7%, increased the soil respiration rate by 17.7%, and decreased the electrical conductivity by 15.6%. Compared with those for CK and ID3, the seed yield for ID2 increased by 2.0% and 5.8%, respectively, and that for ID1 decreased by 1.6%. However, the land equivalent of the ID2 treatment was 4.3% greater than that for the ID1 treatment. Therefore, intercropping cumin at a density of 8×105 plants ha-1 is beneficial for increasing surface coverage, significantly increasing crop water consumption, increasing surface temperature, reducing soil electrical conductivity and carbon emissions, and improving the crop yield and economic benefits. This model can be used as an agroecologically friendly and sustainable planting model.
The impact of physical exercise on adolescents’ mobile phone dependency: the serial mediating role of self-esteem and depression
Authors: Wu Jingtao , Shao Yanhong , Zang Wanli 
Published: February 2025

ObjectiveThe objective of this study is to examine the impact of physical exercise on the prevalence of mobile phone dependency among middle school students, as well as to delineate the serial mediating roles of self-esteem and depression within this relationship.MethodsA convenient cluster random sampling method was employed to conduct a questionnaire survey among 3,786 middle school students from Guangdong, Sichuan, Zhejiang, Henan, and other provinces. Measurements were taken using the Physical Activity Rating Scale (PARS-3), the Self-esteem Scale, the Depression Scale, and the Mobile Phone Dependency Scale.ResultsPhysical exercise was significantly negatively correlated with mobile phone dependency (r = −0.400, p &lt; 0.001) and depression (r = −0.400, p &lt; 0.001), and positively correlated with self-esteem (r = 0.257, p &lt; 0.001). Mobile phone dependency was significantly positively correlated with depression (r = 0.540, p &lt; 0.001) and negatively correlated with self-esteem (r = −0.129, p &lt; 0.001). Depression was negatively correlated with self-esteem (r = −0.396, p &lt; 0.001). Mediation analysis revealed that self-esteem and depression significantly mediated the relationship between physical exercise and mobile phone dependency, with a total indirect effect of −0.116 (95% CI = [−0.239, −0.140]), accounting for 100% of the total effect. Specifically, the indirect effect through “physical exercise influencing depression, which then affects mobile phone dependency” was −0.076 (95% CI = [−0.224, −0.128]), accounting for 65.52% of the total effect; the indirect effect through “physical exercise influencing self-esteem, which then influences depression, and in turn affects mobile phone dependency” was −0.040 (95% CI = [−0.063, −0.027]), accounting for 34.48%; the indirect effect through “physical exercise influencing self-esteem, which then affects mobile phone dependency” was not significant (95% CI included 0).ConclusionPhysical exercise can directly reduce the dependency of middle school students on mobile phones, and it can also indirectly reduce mobile phone dependency by enhancing self-esteem and reducing levels of depression.
Achieving universal health coverage in India: a scoping review on the requisite public health actions
Authors: Radheshyam Avani , Ramani Vinod K. , Naik Radheshyam 
Published: February 2025

IntroductionIn India, large inequities in health exist by geography, gender, socio-economic class, religion and caste. Universal health coverage (UHC) is envisioned to address these gaps. The deficiencies in our healthcare system cannot be solely bridged by additional investment, increasing manpower, adoption of technology or establishing regulatory Institutes. While UHC offers promise, its nation-wide implementation must be carefully planned and monitored.Objectives(1) To review published literature appraising the concepts of UHC such as coverage of health services and financial protection in the Indian healthcare system, (2) To review the deficiencies of the healthcare system in India and explore solutions within the framework of UHC.MethodsThe relevant articles for review were retrieved from PubMed and Google scholar databases using pertinent text terms. This scoping review includes 12 citations and 3 other published reports which address the determinants of UHC and its impact on the healthcare system in India.ResultsUHC aims to address the concept of health in all its dimensions and not merely as a response to illness. This Program’s objectives include reducing the gap between the need and utilization of healthcare, improving its quality and providing financial protection. In India, the public health sector suffers from shortfalls in management, manpower issues and poor accountability, whereas the private health sector is unregulated and contributes to the increasing health expenditure. UHC will improve access to health care and prevent financial impoverishment, which will be advantageous to the rural people and urban poor including workers of the unorganized sector.ConclusionUHC enables health systems to efficiently deliver a wide range of healthcare services to the population, as well as adopt sustainable financing mechanisms. Given the current Covid-19 pandemic and the need to address future pandemics, we need to build resilient health systems as well as hasten the implementation of UHC.
Arbuscular Mycorrhizal Fungi Alleviate Cadmium Phytotoxicity by Regulating Cadmium Mobility, Physiological Responses, and Gene Expression Patterns in Malus hupehensis Rehd
Authors: Zhuang Xiaolei , Liu Siyu , Xu Shengzhe , Qin Sijun , Lyu Deguo , He Jiali , Zhou Jiangtao 
Published: February 2025

Arbuscular mycorrhizal fungi (AMF) affect cadmium (Cd) accumulation and tolerance in host plants. However, the effects of AMF on Cd accumulation and phytotoxicity and their underlying mechanism in apples remain uncharacterized. In this study, the comprehensive physiological and molecular responses of uninoculated and Rhizophagus intraradices-inoculated Malus hupehensis Rehd. rootstocks exposed to 0 or 300 μM Cd were investigated. AMF inoculation mitigated Cd-induced growth and photosynthesis inhibition and nutrient ion disorders. It also lowered the concentrations of Cd in all tissues and reduced Cd transport to the shoots. Compared to uninoculated apple plants, those inoculated with mycorrhizal fungi reduced the mobility and toxicity of Cd by altering its form and binding it to the cell walls of the roots and leaves. AMF inoculation ameliorated Cd stress by altering endogenous phytohormone levels and triggering enzymatic and non-enzymatic antioxidant systems. Transcriptome analysis revealed that the differentially expressed genes (DEGs) associated with AMF under Cd stress regulated carbohydrate and amino acid biosynthesis and metabolism, as well as phytohormone biosynthesis and signal transduction. Furthermore, AMF inoculation downregulated certain genes involved in Cd uptake and transport while upregulating other genes involved in detoxification. These results suggest that AMF alleviate Cd phytotoxicity by orchestrated physiological and transcriptomic regulation in M. hupehensis Rehd., providing valuable insights into the efficacy of AMF inoculation in improving the heavy metal resistance of fruit trees.
Медиа-ландшафт Буркина-Фасо
Authors: Карпенко А.Ю. 
Published: February 2025

В статье рассматриваются особенности системы СМИ в Буркина-Фасо с учетом политического строя страны. Анализируется влияние политической системы на деятельность медиа, включая надзор со стороны Высшего совета по коммуникациям (CSC), а также случаи ограничений и в отношении критиков правительства. Акцентируется внимание на том, как государственный контроль формирует информационное пространство в стране.
The article examines the features of the media system in Burkina Faso, taking into account the country's political system. It analyzes the influence of the political system on media activities, including oversight by the High Council of Communications (CSC), as well as cases of restrictions on government critics. It focuses on how state control shapes the information space in the country.