bluuebunny/crossref_metadata_2025_split huggingface dataset:
VEGFR-1 (FLT-1), β1 integrin, and hERG K+ channel for a macromolecular signaling complex in acute myeloid leukemia: role in cell migration and clinical outcome
Authors: Pillozzi Serena , Brizzi Maria Felice , Bernabei Pietro Antonio , Bartolozzi Benedetta , Caporale Roberto , Basile Venere , Boddi Vieri , Pegoraro Luigi , Becchetti Andrea , Arcangeli Annarosa 
Published: April 2007

AbstractLeukemia cell motility and transendothelial migration into extramedullary sites are regulated by angiogenic factors and are considered unfavorable prognostic factors in acute leukemias. We have studied cross talk among (1) the vascular endothelial growth factor receptor-1, FLT-1; (2) the human eag-related gene 1 (hERG1) K+ channels; and (3) integrin receptors in acute myeloid leukemia (AML) cells. FLT-1, hERG1, and the β1 integrin were found to form a macromolecular signaling complex. The latter mostly recruited the hERG1B isoform of hERG1 channels, and its assembly was necessary for FLT-1 signaling activation and AML cell migration. Both effects were inhibited when hERG1 channels were specifically blocked. A FLT-1/hERG1/β1 complex was also observed in primary AML blasts, obtained from a population of human patients. The co-expression of FLT-1 and hERG1 conferred a pro-migratory phenotype to AML blasts. Such a phenotype was also observed in vivo. The hERG1-positive blasts were more efficient in invading the peripheral circulation and the extramedullary sites after engraftment into immunodeficient mice. Moreover, hERG1 expression in leukemia patients correlated with a higher probability of relapse and shorter survival periods. We conclude that in AML, hERG1 channels mediate the FLT-1–dependent cell migration and invasion, and hence confer a greater malignancy.
RNAi screen identifies UBE2D3 as a mediator of all-trans retinoic acid-induced cell growth arrest in human acute promyelocytic NB4 cells
Authors: Hattori Hidenori , Zhang Xueqing , Jia Yonghui , Subramanian Kulandayan K. , Jo Hakryul , Loison Fabien , Newburger Peter E. , Luo Hongbo R. 
Published: April 2007

AbstractAll-trans retinoic acid (ATRA) has been widely used in differentiation therapy for acute promyelocytic leukemia (APL). ATRA binds to retinoic acid receptor (RAR) and triggers the formation of the transcription coactivator complex, which leads to changes in gene expression, APL cell-cycle arrest and differentiation, and clinical remission. The mechanisms responsible for ATRA's beneficial effects are still ill-defined. Here, we conducted a large-scale, unbiased short hairpin RNA (shRNA) screen aiming to identify mediators of ATRA-induced differentiation and growth arrest of APL cells. Twenty-six proteins were identified. They cover a wide range of cellular functions, including gene expression, intracellular signaling, cell death control, stress responses, and metabolic regulation, indicating the complexity of ATRA-induced cell growth control and differentiation in APL. One of these proteins, the ubiquitin-conjugating enzyme UBE2D3, is up-regulated in ATRA-treated acute promyelocytic NB4 cells. UBE2D3 is physically associated with cyclin D1 and mediates ATRA-induced cyclin D1 degradation. Knocking down UBE2D3 by RNA interference (RNAi) leads to blockage of ATRA-induced cyclin D1 degradation and cell-cycle arrest. Thus, our results highlight the involvement of the ubiquitin-mediated proteolysis pathway in ATRA-induced cell-cycle arrest and provide a novel strategy for modulating ATRA-elicited cellular effects.
Haploinsufficiency of EGR1, a candidate gene in the del(5q), leads to the development of myeloid disorders
Authors: Joslin John M. , Fernald Anthony A. , Tennant Thelma R. , Davis Elizabeth M. , Kogan Scott C. , Anastasi John , Crispino John D. , Le Beau Michelle M. 
Published: April 2007

AbstractLoss of a whole chromosome 5 or a deletion of the long arm, del(5q), is a recurring abnormality in myelodysplastic syndromes (MDSs) and acute myeloid leukemia (AML). To identify a leukemia-related gene on chromosome 5, we previously delineated a 970-kb segment of 5q31 that is deleted in all patients examined, and prepared a transcript map of this region. EGR1 is a candidate tumor suppressor gene within the commonly deleted segment of 5q, and encodes a zinc finger transcription factor. To test the hypothesis that loss of function of Egr1 is an initiating event in the pathogenesis of AML/MDS, Egr1-deficient mice were treated with a potent DNA alkylating agent, N-ethyl-nitrosourea (ENU), to induce secondary cooperating mutations. Egr1+/− and Egr1−/− mice treated with ENU developed immature T-cell lymphomas (CD4+, CD8+) or a myeloproliferative disorder (MPD) at increased rates and with shorter latencies than that of wild-type littermates. The MPD was characterized by an elevated white blood cell count, anemia, and thrombocytopenia with ineffective erythropoiesis. Biallelic mutations of Egr1 were not observed in MPDs in Egr1+/− mice. Our data suggest that haploinsufficiency for Egr1 plays a role in murine leukemogenesis, and in the development of AML/MDS characterized by abnormalities of chromosome 5.
The Role of the Number of Uninvolved Lymph Nodes in Predicting Locoregional Recurrence in Breast Cancer
Authors: Karlsson Per , Cole Bernard F. , Price Karen N. , Coates Alan S. , Castiglione-Gertsch Monica , Gusterson Barry A. , Murray Elizabeth , Lindtner Jurij , Collins John P. , Holmberg Stig B. , Fey Martin F. , Thürlimann Beat , Crivellari Diana , Forbes John F. , Gelber Richard D. , Goldhirsch Aron , Wallgren Arne 
Published: April 2007

Purpose To identify groups of early breast cancer patients with substantial risk (10-year risk > 20%) for locoregional failure (LRF) who might benefit from postmastectomy radiotherapy (RT). Patients and Methods Prognostic factors for LRF were evaluated among 6,660 patients (2,588 node-negative patients, 4,072 node-positive patients) in International Breast Cancer Study Group Trials I to IX treated with chemotherapy and/or endocrine therapy, and observed for a median of 14 years. In total, 1,251 LRFs were detected. All patients were treated with mastectomy without RT. Results No group with 10-year LRF risk exceeding 20% was found among patients with node-negative disease. Among patients with node-positive breast cancer, increasing numbers of uninvolved nodes were significantly associated with decreased risk of LRF, even after adjustment for other prognostic factors. The highest quartile of uninvolved nodes was compared with the lowest quartile. Among premenopausal patients, LRF risk was decreased by 35% (P = .0010); among postmenopausal patients, LRF risk was decreased by 46% (P < .0001). The 10-year cumulative incidence of LRF was 20% among patients with one to three involved lymph nodes and fewer than 10 uninvolved nodes. Age younger than 40 years and vessel invasion were also associated significantly with increased risk. Among patients with node-positive disease, overall survival was significantly greater in those with higher numbers of uninvolved nodes examined (P < .0001). Conclusion Patients with one to three involved nodes and a low number of uninvolved nodes, vessel invasion, or young age have an increased risk of LRF and may be candidates for a similar treatment as those with at least four lymph node metastases.
Synthesis and Reactivities of Sulfido-bridged Ir–W and Ir–Re Heterodinuclear Complexes with Imido Ligands
Authors: Arashiba Kazuya , Tanabe Yoshiaki , Ishii Youichi 
Published: April 2007

Abstract
The iridium hydrosulfido complexes [Cp*IrH(SH)(PPh3)] (Cp* = η5-C5Me5) and [Cp*Ir(SH)2(PMe3)] were found to serve as effective building blocks for the synthesis of mono- and bis(sulfido)-bridged heterodinuclear complexes with a high-valent tungsten or rhenium–imido center.
Chiral Ionic Liquid Containing l-Proline Unit as a Highly Efficient and Recyclable Asymmetric Organocatalyst for Aldol Reaction
Authors: Zhou Li , Wang Lei 
Published: April 2007

Abstract
A functionalized chiral ionic liquid (CIL) containing l-proline unit exhibits as a highly efficient and recyclable asymmetric organocatalyst for aldol condensation of aldehydes and ketones in [Bmim][BF4] at room temperature, which afford the corresponding products with satisfactory isolated yields and enantiomeric excesses.
Surfactant-assisted Hydrothermal Route to Organometallic Tris(8-hydroxyquinoline)aluminum Nanorod Bundles
Authors: Ma Dekun , Zhang Junhao , Hu Xiaokai , Zhou Hongyang , Qian Yitai 
Published: April 2007

Abstract
A new surfactant-assisted hydrothermal route was presented to prepare organometallic tris(8-hydroxyquinoline)aluminum nanorod bundles on a large scale. In this hydrothermal system, sodium dodecylbenzenesulfonate (Chemical formula: C12H25–C6H4–SO3Na, SDBS) played key roles in controlling the morphology and quality of the resultant products. The as-prepared nanorod bundles showed enhanced PL emission compared to submicron particles prepared by the same hydrothermal method.
Symmetry of the pentacene molecule and classification of electron states studied in the frame of group action on a set
Authors: Potera Piotr , Stefaniuk Ireneusz , Kuźma Marian 
Published: April 2007

Abstract
Pentacene have recently become the subject of intense studies due to their physical properties which follow from the states of their outer-shell electrons that are able to take part in molecule bonding. The symmetry of these molecules provides the classification of quantum states according to the group theory method. In this paper, we apply a molecular state-space factorization scheme for the classification of pentacene molecules based on the structure of their electron states.
Evaluation of the inelastic mean free path (IMFP) of electrons in polyaniline and polyacetylene samples obtained from elastic peak electron spectroscopy (EPES)
Authors: Gergely György , Menyhard Miklós , Sulyok Attila , Gurban Sándor , Lesiak Beata , Jablonski Aleksander , Kosinski Andrzej , Toth József , Varga Dezső 
Published: April 2007

Abstract
The inelastic mean free path (IMFP) of electrons was determined experimentally for selected polyaniline and polyacetylene samples with Ag and Ni references using elastic peak electron spectroscopy (EPES). The surface composition was determined by XPS and density by helium pycnometry. The high resolution hemispherical ESA-31 and ADES-400 spectrometers were used for measurements in the energy range E = 0.5–3.0 keV and E =0.4 − 1.6 keV, respectively. The integrated elastic peak intensity ratios for sample and reference were calculated using the Monte Carlo (MC) algorithm based on the electron elastic scattering cross-sections database NIST SRD64 version 3.1 and applying TPP-2M IMFPs for polymers. Surface excitation parameters (SEP) and material parameters (ach) for polymers were determined, using the model of Chen, from comparison of measured and MC calculated elastic peak intensity ratios. These corrections proved to be efficient in decreasing the percentage deviations between the obtained IMFPs and the TPP-2M formula IMFPs. The elastic peak of hydrogen was observed in the EPES spectra of polymers. The experimental contribution of the hydrogen to the total elastic peak was 0.58%, while this value obtained from the MC simulations was 1.98%.
Pulsed ytterbium-doped large mode area double-clad fiber amplifier in MOFPA configuration
Authors: Świderski J. , Zając A. , Skórczakowski M. 
Published: April 2007

AbstractA pulsed master oscillator fiber power amplifier working in nanosecond range has been developed. An ytterbium-doped double-clad (large mode area) optical fiber was used as an amplifying medium. Actively Q-switched Nd:YVO laser was used as a seed of light pulses. The system worked at the repetition rate from 10 kHz to 40 kHz. At the amplifier output, pulses of 10.9 kW peak-power were achieved. The laser system worked at the slope efficiency of 30%.
Prepregnancy weight, inappropriate gestational weight gain, and smoking: Relationships to birth weight
Authors: May Richard 
Published: April 2007

AbstractThis study was designed to test predictors of infant birth weight based on categories of prepregnancy body mass index (BMI), gestational weight gain, and smoking. Data were collected retrospectively from records of 233 mother‐infant pairs enrolled in the Siouxland Women, Infants, and Children (WIC) Program in Sioux City, Iowa. Prepregnancy BMI and gestational weight gain were coded according to Institute of Medicine guidelines. Smoking behavior was coded based on reported smoking during the last 3 months of pregnancy. Multiple regression analysis was used to test predictors of infant birth weight. Forty‐two percent of women gained more weight than recommended, and 16% gained less than recommended. Based on prepregnancy BMI, women were classified as underweight (12%), overweight (16%), or obese (31%). Twenty‐four percent of mothers reported smoking late in gestation. Higher birth weight was predicted by prepregnancy obesity (+144 g). Lower infant birth weight was predicted by lower (−162 g) and higher (−153 g) than recommended weight gain, and by lower (−299 g) and higher (−168 g) levels of smoking. Depression of birth weight among women who gained excess weight may relate to inadequate early weight gain or pregnancy complications. More research is needed regarding physiological consequences of these maternal factors and their associated demographic risk factors.Am. J. Hum. Biol. 19:305–310, 2007. © 2007 Wiley‐Liss, Inc.
HLA genes and surnames show a similar genetic structure in Lombardy: Does this reflect part of the history of the region?
Authors: Lisa Antonella , De Silvestri Annalisa , Mascaretti Luca , Degiuli Alberto , Guglielmino Carmela R. 
Published: April 2007

AbstractLombardy, in northern Italy, is the most populated and industrialized Italian region. We attempt to study its genetic structure with two independent sets of data: HLA allele frequencies and surnames. According to our results, it is plausible to deduce that ancient history, more than genetic isolation and drift, may have contributed to the present genetic structure of Lombardy. The hypothesis seems to be confirmed by the results of the cluster analysis of the 11 provinces of the region, which was performed using two different types of markers. Both genes and surnames show approximately the same structure. Not only Celts but also ancient Ligurians (and Etruscans) probably shaped the region into the present three clusters in which the 11 provinces appear to be genetically structured. In particular, an ancient historic, archaeological, and linguistic boundary, along the Adda River, seems to be preserved in present‐day Lombardy's population structure.Am. J.Hum. Biol. 19:311–318, 2007. © 2007 Wiley‐Liss, Inc.
Size at birth and growth trajectories to young adulthood
Authors: Adair Linda S. 
Published: April 2007

AbstractFew studies in developing countries follow growth trajectories from birth to adulthood. Such studies are important because size at birth and postnatal growth affect risk of chronic disease in adulthood. This study examines the inter‐relationships of maternal factors during pregnancy, infant birth weight and length, early postnatal growth, and young adult height, weight, BMI, and skinfold thicknesses, with particular attention to patterns of growth associated with increased chronic disease risk. Women were recruited in pregnancy, and offspring were followed from birth to age 21 in the community‐based Cebu (Philippines) Longitudinal Health and Nutrition Survey. Birth weight and length are independently, positively associated with height, BMI and sum of skinfolds in young adult males and females, and inversely associated with the subscapular to triceps ratio in males only. The effects of size at birth on adult size were modified by birth order, and remained significant after adjusting for maternal nutritional status, socioeconomic status at birth and throughout the growth period, and maturation. Early postnatal growth was strongly influenced by BMI at birth, with rapid early infant weight gain associated with thinness. The growth pattern of the at‐risk group most often associated with increased risk of chronic disease (small at birth, relatively heavy as an adult), was characterized by more rapid growth in the first 4 postnatal months. The high level of inter‐relatedness of maternal nutrition in pregnancy, prenatal growth, and postnatal growth emphasizes the need to consider the full growth trajectory in studies of developmental origins of adult disease.Am. J. Hum. Biol. 19:327–337, 2007. © 2007 Wiley‐Liss, Inc.
Secular trends in anthropometric characteristics, physical fitness, physical activity, and biological maturation in Flemish adolescents between 1969 and 2005
Authors: Matton Lynn , Duvigneaud Nathalie , Wijndaele Katrien , Philippaerts Renaat , Duquet William , Beunen Gaston , Claessens Albrecht L. , Thomis Martine , Lefevre Johan 
Published: April 2007

AbstractIn this study, secular trends in anthropometric characteristics, physical fitness, physical activity, and biological maturity over the past 25–35 years in Flemish adolescents were investigated. Representative cross‐sectional samples of 12–18‐year‐old secondary school children (11,899 assessments in boys in 1969–1974, 4,899 girls in 1979–1980, 1,429 boys and 1,772 girls in 2005) and parent‐offspring pairs tested at approximately the same age during adolescence (55 father‐son pairs, mean age fathers = 15.47 years, mean age sons = 15.38 years; 62 mother‐daughter pairs, mean age mothers = 16.63 years, mean age daughters = 15.01 years) were used. The cross‐sectional data were analyzed in 6 yearly age‐categories using Wilcoxon rank sum tests. For the parent‐offspring data paired t‐tests, simple linear regressions to adjust for parent‐offspring differences in chronological age and multiple linear regressions to adjust for parent‐offspring differences in chronological and skeletal age were conducted. The cross‐sectional study generally revealed an increase in weight, stature, BMI, skinfolds and trunk‐extremity index, and a decrease in the performance on several physical fitness tests. In the parent‐offspring study, only sons were maturationally advanced compared to fathers. Even after adjustment for parent‐offspring differences in chronological age and in chronological and skeletal age, results for stature, trunk‐extremity index and physical fitness were generally similar to the cross‐sectional study. No secular trend was observed for sports participation. The fact that the positive secular trends in weight, BMI, and skinfolds of the cross‐sectional study were not entirely confirmed in the parent‐offspring study is probably due to higher similarity in genetic and familial background, higher socio‐economic status, and more health‐consciousness of the latter.Am. J. Hum. Biol. 19:345–357, 2007. © 2007 Wiley‐Liss, Inc.
Focused life history data and linear enamel hypoplasia to help explain intergenerational variation in relative leg length within Taiwanese families
Authors: FLOYD B. 
Published: April 2007

AbstractThis study first examines the hypothesis that significant intergeneration increases in stature within 85 Taiwanese families in two study locations were primarily the result of increases in subischial leg length. It then evaluates a second hypothesis that independent assessments of the extent of intergenerational change in childhood environments within these families helped account for parent–offspring differences in relative leg length. Childhood environments were assessed using two criteria: developmental environment scores derived from life history data and evidence of linear enamel hypoplasia (LEH). Relative leg length was represented in two ways, as either the difference between internally estimated sex‐specific z‐scores of sitting height and subischial leg length (zD = zSH − zLL) or as relative sitting height (RSH; sitting height/height × 100). Paired Student t tests indicated intergenerational increases in relative leg length were significantly greater than zero in both study locations (P ≤ 0.012). The second hypothesis, tested using a hierarchical model with maximum likelihood estimation that allowed for nesting of more than one offspring per family, received support as midparent–offspring differences in composite scores were significantly positively associated with midparent–offspring differences in relative leg length. This was true alone (P = 0.018), and when significant associations with LEH prevalence among mothers and offspring were statistically controlled for (P = 0.010). Evidence also indicated that while the large majority of offspring were taller than their midparental average height (84.3%; 91/108), offspring who were taller were also more likely to have relatively longer legs than by chance alone (Fishers exact, P = 0.027).Am. J. Hum. Biol. 19:358–375, 2007. © 2007 Wiley‐Liss, Inc.
Endurance running and digit ratio (2D:4D): Implications for fetal testosterone effects on running speed and vascular health
Authors: Manning John T. , Morris Laura , Caswell Noreen 
Published: April 2007

AbstractThere is anatomical and physiological evidence that endurance running (ER), i.e., running one or more kilometers using aerobic metabolism, originated early in the evolution of Homo, and the consequences of early selection for ER may be important in modern Homo. Here we examine ER performance in competitive ER. ER is sex dependent such that men tend to run faster than women, and the influence of sex on ER suggests that it may be modified by testosterone (T). It is shown that a putative proxy for prenatal T, the ratio of the length of the 2nd and 4th digits (2D:4D), is correlated with ER. Thus performance in training for ER was associated with high prenatal T, as measured by low 2D:4D, in both men and women. In cross‐country races from 1 to 4 miles, 2D:4D explained about 25% of the variance in both male and female ER. Therefore, speed in ER was dependent on a proxy for prenatal T. 2D:4D correlates with performance in sport and exercises, which test a mix of strength and fitness, but the associations are in general quite weak with 2D:4D accounting for less than 10% of the variance in performance. Our finding that 2D:4D explains about 25% of the variance in ER suggests that prenatal T is important in determining efficiency in aerobic exercise. Early populations of Homo may have been strongly selected for ER and high prenatal T. The implications of this for patterns of predisposition to cardiovascular disease in modern Homo are discussed.Am. J. Hum. Biol. 19:416–421, 2007. © 2007 Wiley‐Liss, Inc.
Y‐chromosome lineages in São Tomé e Príncipe islands: Evidence of European influence
Authors: Gonçalves Rita , Spínola Hélder , Brehm António 
Published: April 2007

AbstractThe Y‐chromosome haplogroup composition of the population of São Tomé e Príncipe (STP) archipelago was analyzed using 25 biallelic markers and compared with populations of different origins from Europe, Africa, and the Middle East. Two main Y‐chromosome haplogroups were found: E3a, very common among sub‐Saharans accounts for 84.2% of the paternal lineages and R1b, typical of West Eurasia, represents 8.7% of the overall male population. Nevertheless, we detected in the population of STP a significant heterogeneous distribution of R1b among the two main ethnic groups of the archipelago: Forros (10.3%) and Angolares (6.6%). Together, haplogroups known to be prevalent in West Eurasia reach 12.5% of the chromosomes analyzed unequally distributed among the two groups: Forros present 17.7% while Angolares display only 8.2% of west Eurasian haplogroups. Our findings suggest that, despite its sub‐Saharan genetic background, a relevant contribution of European paternal lineages is present in nowadays STP population. This influence has shown to be stronger in Forros than in Angolares, which could be explained by the social isolation that these have last experienced through their history.Am. J. Hum. Biol. 19:422–428, 2007. © 2007 Wiley‐Liss, Inc.