bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gambaran Perilaku Praktek Pencegahan Demam Berdarah Dengue Di Kelurahan Gagaksipat Kabupaten Boyolali
Authors: Yusup Nur Avinda , Martini Martini , Hestiningsih Retno , Kusariana Nissa 
Published: March 2024

Kelurahan Gagaksipat merupakan daerah endemis DBD. Kasus DBD tertinggi berada di wilayah kerja Puskesmas Ngemplak tepatnya di Desa Gagaksipat. Kegiatan pemberantasan sarang nyamuk dapat mencegah keberadaan larva Aedes. Penelitian ini bertujuan untuk memberikan gambaran tentang perilaku terkait praktik pencegahan DBD. Penelitian ini merupakan penelitian observasional analitik dengan metode single larva. Desain penelitian yang digunakan adalah cross sectional. Sampel sebanyak 100 KK menggunakan teknik systematic random sampling. Hasil penelitian menyatakan bahwa sebagian besar masyarakat memiliki pengetahuan baik (55%), sikap baik (59%) dan praktik baik (58%). Berdasarkan hal tersebut, diharapkan tenaga kesehatan terus memberikan pendampingan dan dukungan untuk meningkatkan perilaku praktik pencegahan DBD.
Hubungan Tingkat Pengetahuan Ibu dengan Praktik Penatalaksanaan Diare pada Balita
Authors: Utami Rosiana Putri , Wurjanto Moh. Arie , Martini Martini 
Published: March 2024

Abstract: Diarrhea is a disease that occurs when a person has at least three loose stools per day. Diarrhea is considered a mild disease, but it can be fatal if not treated properly, especially in toddlers and children. The involvement of the mother in the management of diarrhea in toddlers is necessary. The aim of this study is to study the relationship between mother’s knowledge and diarrhea management practices in toddler in the Working Area of Puskesmas Sumowono, Semarang Regency. In this study focused on observational analytical studies using cross-sectional design. This study’s sample size was 122 respondents. The univariate test findings showed that the majority of respondents (54,1%) are high school graduates, 59,8% have adequate knowledge, and 59,8% have good practices for managing with diarrhea in toddlers. The bivariate analysis discovered a correlation between mother’s knowledge and diarrhea management practices (p=0.000). The most of respondents had sufficient knowledge and practice (74,0%). Keywords: Mothers’s knowledge, toddler diarrhea, diarrhea management
Diurnal and circadian regulation of opsin-like transcripts in the eyeless cnidarian Hydra
Authors: Santillo Silvia , De Petrocellis Luciano , Musio Carlo 
Published: March 2024

Abstract
Opsins play a key role in the ability to sense light both in image-forming vision and in non-visual photoreception (NVP). These modalities, in most animal phyla, share the photoreceptor protein: an opsin-based protein binding a light-sensitive chromophore by a lysine (Lys) residue. So far, visual and non-visual opsins have been discovered throughout the Metazoa phyla, including the photoresponsive Hydra, an eyeless cnidarian considered the evolutionary sister species to bilaterians. To verify whether light influences and modulates opsin gene expression in Hydra, we utilized four expression sequence tags, similar to two classic opsins (SW rhodopsin and SW blue-sensitive opsin) and two non-visual opsins (melanopsin and peropsin), in investigating the expression patterns during both diurnal and circadian time, by means of a quantitative RT-PCR. The expression levels of all four genes fluctuated along the light hours of diurnal cycle with respect to the darkness one and, in constant dark condition of the circadian cycle, they increased. The monophasic behavior in the L12:D12 cycle turned into a triphasic expression profile during the continuous darkness condition. Consequently, while the diurnal opsin-like expression revealed a close dependence on light hours, the highest transcript levels were found in darkness, leading us to novel hypothesis that in Hydra, an “internal” biological rhythm autonomously supplies the opsins expression during the circadian time. In conclusion, in Hydra, both diurnal and circadian rhythms apparently regulate the expression of the so-called visual and non-visual opsins, as already demonstrated in higher invertebrate and vertebrate species. Our data confirm that Hydra is a suitable model for studying ancestral precursor of both visual and NVP, providing useful hints on the evolution of visual and photosensory systems.
Estimating the slip rate in the North Tabriz Fault using focal mechanism data and GPS velocity field
Authors: Salmanian Milad , Rastbood Asghar , Hossainali Masoud Mashhadi 
Published: March 2024

Abstract
This study delves into slip distribution on the North Tabriz Fault (NTF), a critical aspect of seismic hazard analysis due to its proximity to the Tabriz metropolis. The study operates within a uniform elastic half-space, maintaining constant values for fault geometry and regional rheological parameters throughout the research. To calculate strain boundary conditions, permanent and periodic global positioning system (GPS) data from the northwest region were utilized. The fault was constrained perpendicularly while allowing tangential movement, facilitating the determination of its annual slip rate using the boundary element method, with the Okada analytical model serving as the fundamental solution. The findings underscore the intricate relationship between the fault’s slip rate and boundary conditions, revealing a predominant right-lateral strike-slip motion. The study offers two slip rate assessments, obtained through earthquake focal mechanisms and GPS velocity data, yielding values of 5 and 5.5

mm

/

year

{\rm{mm}}/{\rm{year}}

, respectively. Importantly, the alignment of these calculated slip rates with paleo-seismological data underscores the credibility of the results generated via the boundary element method, distinguishing it as a reliable approach when compared to other numerical and analytical techniques. This research provides valuable insights into the behavior and slip dynamics of the NTF, which is pivotal for assessing seismic risks.
Assembling the RNA therapeutics toolbox
Authors: Teng Mona , Xia Ziting Judy , Lo Nicholas , Daud Kashif , He Housheng Hansen 
Published: March 2024

Abstract
From the approval of COVID-19 mRNA vaccines to the 2023 Nobel Prize awarded for nucleoside base modifications, RNA therapeutics have entered the spotlight and are transforming drug development. While the term “RNA therapeutics” has been used in various contexts, this review focuses on treatments that utilize RNA as a component or target RNA for therapeutic effects. We summarize the latest advances in RNA-targeting tools and RNA-based technologies, including but not limited to mRNA, antisense oligos, siRNAs, small molecules and RNA editors. We focus on the mechanisms of current FDA-approved therapeutics but also provide a discussion on the upcoming workforces. The clinical utility of RNA-based therapeutics is enabled not only by the advances in RNA technologies but in conjunction with the significant improvements in chemical modifications and delivery platforms, which are also briefly discussed in the review. We summarize the latest RNA therapeutics based on their mechanisms and therapeutic effects, which include expressing proteins for vaccination and protein replacement therapies, degrading deleterious RNA, modulating transcription and translation efficiency, targeting noncoding RNAs, binding and modulating protein activity and editing RNA sequences and modifications. This review emphasizes the concept of an RNA therapeutic toolbox, pinpointing the readers to all the tools available for their desired research and clinical goals. As the field advances, the catalog of RNA therapeutic tools continues to grow, further allowing researchers to combine appropriate RNA technologies with suitable chemical modifications and delivery platforms to develop therapeutics tailored to their specific clinical challenges.
Methodology for Biomass Determinations and Microbial Activities in Sediments
Authors: Litchfield CD , Seyfried PL 
Published: March 2024

Description
To date, there has not been a single source to which the investigator can refer for guidance on the techniques of microbial ecology that have been successfully adapted and tested in sedimentary systems. STP 673, Methodology for Biomass Determinations and Microbial Activities in Sediments, fills this gap. It presents new data that concentrate on how to apply to sediments the newly developing technique of microbial ecology.. It is hoped that ASTM's STP 673 will not only provide a central source for information on the state of the art in sedimentary microbiology, but that these procedures will serve as references for future testing, modification and improvement.
Studi Linguistik Nama Brand Berbahasa Jawa pada Produk Teh
Authors: Adinatha Giovani , Hemas Saras Fairuz 
Published: March 2024

This research focused on tea brand names derived from Javanese language. The objective is to describe the name’s structure andmeaning. Descriptive-qualitative approach was used in this research with data from two online marketplace, Shopee andTokopedia, focusing only on tea brand names derived from Javanese language. The data were chosen by using purposive samplingtechnique and recorded by taking screenshots Shopee and Tokopedia. The data were analyzed by content analysis technique. Datavalidity was retrieved by researcher’s triangulation and persistency. The triangulation was conducted by analysing data, done bymore than one researcher. After they were analyzed, data were presented both formally and informally. Results from this researchis that tea brand names derived from Javanese language are consist of words and phrases. Meanings that were found in thosestructure are toponymy descriptors, fictional characters names, iconic names, symbolism names, suggestive names, culture-relatednames, and metaphors.
Keywords: brand names; tea products; Javanese language
Pemaknaan Motif Truntum Batik Surakarta: Kajian Semiotik Charles W. Morris
Authors: Widodo Widodo , Soekarba Siti Rohmah , Kusharjanto Bram 
Published: March 2024

Batik is an artistic culture inherited from the ancestors of the Indonesian people which has noble values, has become the pride of the Javanese. This paper describes the meaning of the Surakarta batik Truntum motif in the semiotic study of Charles W. Morris and Frued's psychoanalytic analysis. Morris semantics are used to find the meaning behind the Surakarta batik Truntum motif: Tanjung flower motifs, stars, gurdho (garuda), rhombuses, and colors. Meanwhile, Freud's id is applied to the meaning of sexual desire for the perpetrator in the process of creating motives. The methodology used is multidisciplinary, combining historical approaches, semiotics, and cultural studies. The results of the analysis show that Trumtum batik as a noble art has crossed a long time and has a dialectic with cultural developments. The Trumtum motif is a unification of symbols which are interpreted in spiritual syncretism. Ratu Kencana (Beruk) in lamenting loneliness, sadness, and loneliness manifests itself through the distribution of 'id' and 'sublime' into Truntum batik art.
Keywords: Truntum Motif, Meaning, Semiotics, Morris, Culture
Hukum Ekspor Ganja menurut Majelis Ulama Indonesia dan Undang-Undang Nomor 35 Tahun 2009 tentang Narkotika
Authors: Sholikin Irvan Noor , Faridah Khalwah , Kharisma Niawati , Rohmatin Siti 
Published: March 2024

Indonesian Ulema Council (MUI) and Law Number 35 of 2009 concerning Narcotics. Research data was collected through documentation and interviews and then analyzed comparatively, comparing marijuana export laws according to the Indonesian Ulema Council (MUI) and Law Number 35 of 2009 concerning Narcotics. This study concluded that the export of marijuana, according to the MUI, is not allowed or called haram. This is based on marijuana exports based on Islamic law, that Islamic law prohibits the consumption of marijuana and its distribution. It is also based on the rule of la dharara wa la dhirara (must not cause harm to oneself, nor harm others). According to Article 18 of Law Number 35 of 2009 concerning Narcotics, marijuana exports may be carried out if there is permission from the minister to pharmaceutical companies under the provisions of laws and regulations.
Keywords: export, Marijuana, Islamic law, MUI, law.
Abstrak: Artikel ini membahas tentang ekspor ganja menurut Majelis Ulama Indonesia (MUI) dan Undang-Undang Nomor 35 Tahun 2009 tentang Narkotika. Data penelitian dihimpun melalui dokumentasi serta wawancara kemudian dianalisis dengan komparatif, yaitu membandingkan hukum ekspor ganja menurut Majelis Ulama Indonesia (MUI) dan Undang-Undang Nomor 35 Tahun 2009 tentang Narkotika. Penelitian ini menyimpulkan bahwa ekspor ganja menurut MUI tidak diperbolehkan atau disebut dengan haram. Hal tersebut didasarkan pada dasarkan ekspor ganja pada pinsip hukum Islam, bahwa hukum Islam mengharamkan konsumsi ganja dan penyalurannya. Hal tersebut juga didasarkan pada kaidah la dharara wa la dhirara (tidak boleh menimbulkan atau menyebabkan bahaya bagi diri sendiri, dan tidak boleh pula membahayakan orang lain). Menurut pasal 18 Undang-Undang Nomor 35 Tahun 2009 tentang Narkotika, ekspor ganja boleh dilakukan bila ada izin dari menteri kepada perusahaan farmasi sesuai dengan ketentuan peraturan perundang-undangan.
Kata Kunci: ekspor, Ganja, hukum Islam, MUI, undang-undang.
Meminang Pinangan Orang Lain Menurut Kompilasi Hukum Islam dan Ulama Fiqih
Authors: Mughni Syafiq , Fiqoh Amilatul , Yansa Fiki Angga , Roikhah Iva Farikhatur 
Published: March 2024

Before carrying out a marriage there are stages in the form of a proposal or it can be called a khitbah. Propose comes from the word Pinang with the verb propose. The equivalent of the word propose is applying and in Arabic is khitbah. Proposal in language is asking a woman to be his wife, both for himself and for others. Khitbah is a statement of the man's desire for a certain woman to marry him and the woman announces this engagement.
Proposal is one of the important stages before a marriage is carried out, through a proposal it is hoped that both parties can get to know each other better. Therefore in this article the author will discuss further about the proposal, which aims to provide detailed insight to the reader through the research results of this article
WWP2 Regulates Renal Fibrosis and the Metabolic Reprogramming of Profibrotic Myofibroblasts
Authors: Chen Huimei , You Ran , Guo Jing , Zhou Wei , Chew Gabriel , Devapragash Nithya , Loh Jui Zhi , Gesualdo Loreto , Li Yanwei , Jiang Yuteng , Tan Elisabeth Li Sa , Chen Shuang , Pontrelli Paola , Pesce Francesco , Behmoaras Jacques , Zhang Aihua , Petretto Enrico 
Published: March 2024

Key Points

WWP2 expression is elevated in the tubulointerstitium of fibrotic kidneys and contributes to CKD pathogenesis and progression.WWP2 uncouples the profibrotic activation and cell proliferation in renal myofibroblasts.WWP2 controls mitochondrial respiration in renal myofibroblasts through the metabolic regulator peroxisome proliferator-activated receptor gamma coactivator 1-alpha.

Background
Renal fibrosis is a common pathologic end point in CKD that is challenging to reverse, and myofibroblasts are responsible for the accumulation of a fibrillar collagen–rich extracellular matrix. Recent studies have unveiled myofibroblasts' diversity in proliferative and fibrotic characteristics, which are linked to different metabolic states. We previously demonstrated the regulation of extracellular matrix genes and tissue fibrosis by WWP2, a multifunctional E3 ubiquitin–protein ligase. Here, we investigate WWP2 in renal fibrosis and in the metabolic reprograming of myofibroblasts in CKD.

Methods
We used kidney samples from patients with CKD and WWP2-null kidney disease mice models and leveraged single-cell RNA sequencing analysis to detail the cell-specific regulation of WWP2 in fibrotic kidneys. Experiments in primary cultured myofibroblasts by bulk-RNA sequencing, chromatin immunoprecipitation sequencing, metabolomics, and cellular metabolism assays were used to study the metabolic regulation of WWP2 and its downstream signaling.

Results
The tubulointerstitial expression of WWP2 was associated with fibrotic progression in patients with CKD and in murine kidney disease models. WWP2 deficiency promoted myofibroblast proliferation and halted profibrotic activation, reducing the severity of renal fibrosis in vivo. In renal myofibroblasts, WWP2 deficiency increased fatty acid oxidation and activated the pentose phosphate pathway, boosting mitochondrial respiration at the expense of glycolysis. WWP2 suppressed the transcription of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), a metabolic mediator of fibrotic response, and pharmacologic inhibition of PGC-1α partially abrogated the protective effects of WWP2 deficiency on myofibroblasts.

Conclusions
WWP2 regulates the metabolic reprogramming of profibrotic myofibroblasts by a WWP2-PGC-1α axis, and WWP2 deficiency protects against renal fibrosis in CKD.
Aprendizagem baseada em casos virtuais como suporte a módulo curricular no curso médico
Authors: Caldas Nádia , Aleluia Ieda Maria Barbosa , Menezes Marta , Silva Mary Gomes , Santos Gilmara Ribeiro , Aguiar Carolina Villa Nova 
Published: March 2024

CONTEXTO: Trata-se de um relato de experiência sobre a aprendizagem baseada em casos virtuais como suporte a módulo curricular do curso de Medicina de uma instituição de ensino privado da cidade do Salvador-Bahia-Brasil. Ao reconhecer que é imperativo que o estudante realize simulações/experimentações, emerge a possibilidade de se colocar em prática estudos de casos clínicos com suporte virtual, como estratégia para promover a formação do futuro médico. INTERVENÇÃO: Nesse relato, é abordada a estratégia de ensino-aprendizagem a partir do ano de 2007 em um componente curricular do 6º semestre, que tem como principal objetivo educacional o desenvolvimento do raciocínio clínico. RESULTADOS: Este relato é construído a partir da experiência do docente-observador-participante, que atuou desde o planejamento e a implantação inicial até a reformulação atual, com a introdução de inovações tecnológicas. O componente curricular “Clínica Integrada II”, aplicado no 6º semestre da graduação médica, ganhou, em 2007, o recurso de caso virtual para dar suporte ao desenvolvimento do raciocínio clínico e garantir o estudo prévio dos casos clínicos antes do momento presencial. Em 2021, com o intuito de incorporar e manter, para além da pandemia, as inovações tecnológicas realizadas ao longo do tempo, introduziu-se o recurso do simulador virtual Paciente 360. CONCLUSÃO: O cenário da inovação tecnológica não conflita com os princípios e objetivos da educação e práticas nos serviços de saúde, sendo adjuvantes importantes para o docente na atualidade, o que é demonstrado nesse relato.
Augmentation of Additional Arabic Dataset for Jawi Writing and Classification Using Deep Learning
Authors: Razali Safrizal , Muchtar Kahlil , Rinaldi Muhammad Hafiz , Nurdin Yudha , Rahman Aulia 
Published: March 2024

This research aims to create an additional dataset containing Arabic characters for writing Jawi script and to train classification models using deep learning architectures such as InceptionV3 and ResNet34. The initial stage of the study involves digital image processing to obtain the additional Arabic character dataset from several sources, including HMBD, AHAWP, and HUCD, encompassing various connected and disconnected forms of Jawi script. Image processing includes steps such as preprocessing to enhance image quality, segmentation to separate Arabic characters from the background, and augmentation to increase dataset variability. Once the dataset is formed, we train the models using appropriate training data for each InceptionV3 and ResNet34 architecture. The classification evaluation results indicate that the model with ResNet34 architecture achieved the best performance with an accuracy of 96%. This model successfully recognizes Jawi script accurately and consistently, even for classes with similar shapes. The main contribution of this research is the availability of the additional Arabic character dataset that can be utilized for Jawi script recognition and performance assessment of various deep learning models. The study also emphasizes the importance of selecting the appropriate architecture for specific character recognition tasks. The research findings affirm that the model with ResNet34 architecture has excellent capability in recognizing the additional Arabic characters for writing Jawi. The results of this research have the potential to support further developments in Jawi character recognition applications and provide valuable insights for researchers in the field of character recognition sourced from Arabic characters. Dataset augmentation results can be accessed at https://singkat.usk.ac.id/g/En0skCKGAR
Problemy wydawnicze Zbioru rytmów duchownych, moralnych, panegirycznych i światowych Elżbiety Drużbackiej: Rekonesans
Authors: Kalamon Ilona 
Published: March 2024

Tematem artykułu są zagadnienia związane z powstaniem i wydaniem Zbioru rytmów duchownych, moralnych, panegirycznych i światowych (1752) Elżbiety Drużbackiej. Omówione zostały okoliczności, w jakich Skarbnikowa nawiązała kontakt z braćmi Załuskimi, etapy prac nad przygotowaniem tomu do druku, a także działania Józefa Andrzeja Załuskiego, mające na celu promocję książki. Została także przedstawiona skomplikowana sytuacja drukarska, związana z edycją z 1752 r., oraz wskazane trudności, z jakimi będzie musiał się zmierzyć przyszły wydawca tekstów Drużbackiej.
Powieści Joanny Bator z perspektywy krytyki postkulturalnej
Authors: Kocsis Adrienn 
Published: March 2024

Artykuł bada powieści Joanny Bator za pomocą postkolonializmu, feminizmu, psychoanalizy i teorii afektywności. Ważną kwestią jest tożsamość i przedstawienie elementów, które mają wpływ na jej zmiany i ich kształtowanie.
Języki wygnania. O Analfabetce Agoty Kristof
Authors: Panas Paweł 
Published: March 2024

W artykule została poddana analizie autobiograficzna proza Agoty Kristof, pisarki francuskiej, z pochodzenia Węgierki. Uważna lektura Analfabetki. Opowieści autobiograficznej, książki z 2004 r., jest punktem wyjścia do rozważań nad problemem wyboru języka na emigracji. Decyzje z tym związane mają kluczowe znaczenie dla tożsamości twórców, a motywacje za nimi stojące mogą być bardzo zróżnicowane. W artykule została opisana droga obrana przez Kristof i sposób, w jaki o niej mówi, tytułowa zaś metafora „analfabetki” w metaforyczny sposób odsyła do paradoksu utraty i odzyskiwania mowy poprzez zmianę języka. Rozważania dotyczące tekstów Kristof zostały dodatkowo skonfrontowane z perspektywą polskich twórców emigracyjnych (Konstantego A. Jeleńskiego i Gustawa Herlinga-Grudzińskiego), tworząc tym samym swoisty dialog wygnańców, poszukujących najlepszych środków wyrazu dla własnych tęsknot i pragnień.