bluuebunny/crossref_metadata_2025_split huggingface dataset:
Building a culture of innovation: Innovation 360°
Authors: Cheong Calvin W. H. , She Long , Ma Lan , Karim Sitara , Chan Ling‐Foon , Chong Poh Ling , Choong Pai Wei , Gan Chin Chuan , Gultom Nampuna Dolok , Homer Stephen T. , Hossain Syed Monirul , Leong Ken Yien , Nga Joyce , Piprani Arsalan Zahid , Poon Wai Chuen , Singh Jaspal , Tehseen Shehnaz , Wong Evelyn Mei Ling 
Published: April 2024

AbstractThis study seeks to explore how companies around the world create a culture of innovation by examining common themes that underpin innovation. Through a case study approach, we examined the innovation practices of nine companies and identified six key themes prevalent across all companies: (1) emphasis on research and development; (2) flexibility and adaptability; (3) diversity and inclusion; (4) continuous learning and development; (5) risk‐taking and experimentation; and (6) sustainability. Building on these themes, we propose a new framework for creating a culture of innovation, called the Innovation 360° framework—a systematic approach for companies to understand and build a culture of innovation. Innovation 360° is centered on the core tenets of diversity, inclusion, and sustainability, driven by internal “pull” and external “push” factors of innovation that emphasize flexibility and adaptability, continuous learning and development, and risk‐taking and experimentation. We also discuss the practical benefits and potential drawbacks of the framework. Ultimately, by embracing this framework, companies can improve their innovation capacity and stay ahead of the competition while demonstrating their commitment to social responsibility. However, careful consideration of the framework's potential limitations is necessary to ensure its suitability for different types of companies and industries.
Virtual reality and mental imagery towards travel inspiration and visit intention
Authors: Assiouras Ioannis , Giannopoulos Antonios , Mavragani Eleni , Buhalis Dimitrios 
Published: April 2024

AbstractThe study examines the relationship between virtual reality (VR)‐facilitated mental imagery and travellers' intention to visit a destination. A serial mediation process through travel inspiration (inspired‐by and inspired‐to) is proposed as a psychological mechanism able to explain the positive relationship of elaboration and quality of mental imagery with visit intentions. VR users were recruited through Prolific Academic. The findings demonstrate that VR‐facilitated elaboration of mental imagery increases travel inspiration and consequently visit intention. However, the importance of mental imagery quality is much lower. The paper contributes to the literature of pre‐travel VR experience by exploring the role of travel inspiration.
Aggregate composition directly affects the characteristics of soil microbial and nematode communities in a chronosequence of Chinese fir plantations
Authors: Liao Zongxin , Ye Shaoming , Wang Shengqiang 
Published: April 2024

AbstractMaintaining soil biological diversity is an effective approach in facilitating Chinese fir plantations' sustainable development. However, dynamic characteristics of soil microbial and nematode communities during Chinese fir planting remain unclear, particularly on the aggregate scales, which are the main sites of soil biological activity. Therefore, the research aims to explore how stand age (3, 9, 17, and 26 years) of Chinese fir plantations affects soil microbial biomass (including bacteria, fungi, and actinomycetes, based on the phospholipid fatty acid method), nematode abundances (including bacterivores, fungivores, plant parasites, and omnivores‐predators, based on the modified Baermann funnel method), and their diversity within aggregates of differing sizes (>2, 2–1, 1–0.25, and <0.25 mm). According to the findings, both aggregate size and stand age were major factors affecting soil microbes and nematodes in Chinese fir plantations. Specifically, soil microbial biomass (mainly bacteria), nematode abundances (except fungivores), and their diversity peaked within large macro‐aggregates (>2 mm), and the ranking order for stand ages was 17 > 9 ≈ 3 > 26 years. As the main fractions of soil aggregates in Chinese fir plantations, large macro‐aggregates had suitable internal environments for soil microbial propagation and nematode growth and mainly accumulated at 17 years, which caused the prosperity of soil microbes and nematodes at this stand age. Moreover, the partial least squares path model demonstrated that the influence of stand age on soil microbes and nematodes was indirect; but rather, the aggregate composition played a direct role in shaping their communities. Therefore, in order to maintain soil biological diversity, large macro‐aggregates should be protected during the growth of Chinese fir, especially at the late stage (from 17 to 26 years). Overall, these results could provide valuable insights into Chinese fir plantations' sustainable development.
Recent warming of the Kuroshio Current has promoted offshore sediment transport in the Yellow Sea
Authors: Shi Yong , Xu Xiaomei , Liu Tao , Yang Guang , Liu Shengjing , Lyu Jixuan , Zhang Shuo , Sheng Hui , Gao Jianhua 
Published: April 2024

AbstractAs cross‐shelf gradients of most properties are typically much steeper than those in the alongshore direction, transport across isobaths tends to be inhibited, particularly at oceanic fronts where cross‐shelf gradients are markedly pronounced. Consequently, variations in cross‐shelf gradients may exert a significant influence on offshore transport; however, this influence is not yet well understood. This study employs reconstructed daily suspended sediment concentration (SSC) data from the Yellow Sea's offshore region to investigate the dynamics of offshore transport. Our analysis on an interannual scale shows that offshore SSC correlates more with temperature gradients at the oceanic front than with winter storms, despite the latter's vital role in causing frontal instability. The observed increase in offshore transport over the past two decades is likely connected to Kuroshio Current warming, which has strengthened the horizontal density gradient at the oceanic front, driving the strengthened offshore transport of coastal sediments during instability episodes.
Sensitive Filter‐Free Narrowband Infrared Photodetectors for Weak Light Detection and Ranging
Authors: He Yin , Han Zeyao , Li Junyu , Gu Yu , Zou Yousheng , Wang Yao , Yang Jialin , Lei Wei , Xu Xiaobao 
Published: April 2024

AbstractLight detection and ranging (Lidar), which utilizes scattered near‐infrared (NIR) light to identify objects, has shown great potential in remote sensing, autonomous driving, robotic vision, etc. However, the intensity of the scattered NIR light is significantly reduced, placing stringent demands on the selectivity and fast response of the sensing. Even though optical filters can be used to select weak signals, the photon losses arising from additional interfaces are inevitable, thus reducing the signal‐to‐noise ratio (SNR). In this work, a series of organic narrowband photodetectors are constructed with tunable and selective responses from 700 to 950 nm with a minimum full‐width‐at‐half‐maximum (FWHM) of ≈30 nm. To enhance response sensitivity and speed, delicate and compact photodiode architecture is applied through comprehensive device engineering. As a result, the detectors possess a sensitive response to weak NIR light with a detection limit of 3 nW, and response rise time (τr) and decay time (τd) of ≈24 ns and ≈1.3 µs, respectively. Moreover, a proof‐of‐concept Lidar based on these organic photodetectors is demonstrated with a distance resolution of ≈10 cm, which further confirms the great potential in practical application.
An Injectable Nanocomposite IPN Hydrogel Based on Gelatin Methacrylate/Alginate/COF for Tissue Engineering Applications
Authors: Saleki Samin , Nouri Khorasani Saied , Khalili Shahla , Hafezi Mahshid , Najarzadegan Mahsa , Molaviyan Mohammad Reza , Dinari Mohammad , Kakapour Ali 
Published: April 2024

AbstractThe primary request nowadays is for innovative and superior scaffold designs that mimic the characteristics of native tissue in cartilage tissue engineering. GelMA/Alginate (G/A) interpenetrating polymer network (IPN) has become a popular hydrogel material for tissue engineering because of its superior mechanical and biological properties. Here, to balance the properties, a hydrogel composed of G/A and covalent organic frameworks (COF) nanoparticles is specially designed. In this study, a hydrogel of GelMA/Alginate/COF (G/A/C) with improved properties such as pore size, swelling, mechanical strength, shear‐thinning behavior, and biocompatibility is produced. Furthermore, the G/A/C hydrogel facilitate the printing of complex three dimensional (3D) scaffolds. The test result demonstrates that the addition of COF up to 1% (w/w) enhances the porosity and decreases pore size (0.2 times), improves the compression strength (six times), and decreases the degradation ratio (0.05 times) and the swelling (0.3 times) compared to the G/A hydrogel sample. Besides, the cell viability test confirms the cell growth during the incubation and great biological behavior (more than 98%). The suitable performance of the G/A hydrogel containing 1% COF and its shape fidelity during the injection by 3D printer is confirmed. Nanocomposite IPN hydrogel based on G/A/C could be useful in tissue engineering applications.
Malformations of cortical development: Fetal imaging and genetics
Authors: Wang Lin‐Lin , Pan Ping‐Shan , Ma Hui , He Chun , Qin Zai‐Long , He Wei , Huang Jing , Tan Shu‐Yin , Meng Da‐Hua , Wei Hong‐Wei , Yin Ai‐Hua 
Published: April 2024

AbstractBackgroundMalformations of cortical development (MCD) are a group of congenital disorders characterized by structural abnormalities in the brain cortex. The clinical manifestations include refractory epilepsy, mental retardation, and cognitive impairment. Genetic factors play a key role in the etiology of MCD. Currently, there is no curative treatment for MCD. Phenotypes such as epilepsy and cerebral palsy cannot be observed in the fetus. Therefore, the diagnosis of MCD is typically based on fetal brain magnetic resonance imaging (MRI), ultrasound, or genetic testing. The recent advances in neuroimaging have enabled the in‐utero diagnosis of MCD using fetal ultrasound or MRI.MethodsThe present study retrospectively reviewed 32 cases of fetal MCD diagnosed by ultrasound or MRI. Then, the chromosome karyotype analysis, single nucleotide polymorphism array or copy number variation sequencing, and whole‐exome sequencing (WES) findings were presented.ResultsPathogenic copy number variants (CNVs) or single‐nucleotide variants (SNVs) were detected in 22 fetuses (three pathogenic CNVs [9.4%, 3/32] and 19 SNVs [59.4%, 19/32]), corresponding to a total detection rate of 68.8% (22/32).ConclusionThe results suggest that genetic testing, especially WES, should be performed for fetal MCD, in order to evaluate the outcomes and prognosis, and predict the risk of recurrence in future pregnancies.
Associations between waist circumference and nocturia in adults: National health and nutrition examination survey 2005–2020
Authors: Wang Junwei , Zhang Aiwei , Zhang Cunming , Ye Miaoyong 
Published: April 2024

AbstractBackgroundThe relationship between waist circumference and nocturia has not been previously studied. This study investigated the association between waist circumference and the occurrence of nocturia in adults.MethodsWe analyzed data from the National Health and Nutrition Examination Survey covering 2005–2020, encompassing 6287 adults aged ≥20. Nocturia was defined as the need to urinate two or more times during the night. First, we compared baseline characteristics between the nocturia and non‐nocturia groups. Subsequently, we used multivariate logistic regression analysis to investigate the relationship between waist circumference and nocturia prevalence. We also employed restricted cubic spline analysis to study the potential nonlinear correlation between waist circumference and the prevalence of nocturia. Recognizing the baseline data's heterogeneity based on nocturia prevalence, we conducted subgroup analyses according to age, sex, body mass index (BMI), and ethnicity.ResultsOur findings indicated that females, individuals aged ≥50, citizens, Non‐Hispanic Black, those with lower education levels (high school or less), higher BMIs, lower family income‐to‐poverty ratios, higher waist circumference, hypertension, and diabetes were more likely to experience nocturia. Compared with individuals in the lowest waist circumference quartile (Q1), those in the higher quartiles (Q4) exhibited an increased risk of nocturia in Model 1 (Q4, OR:2.00, 95% CI:1.64, 2.45, p < 0.0001). These results remained consistent after adjusting for covariates in models 2 and 3. A restricted cubic spline analysis suggested a linear association between waist circumference and nocturia (P for nonlinearity = 0.066). Subgroup analyses based on age, sex, BMI, and ethnicity revealed no significant differences in the interaction tests between waist circumference and nocturia (P for interaction = 0.437, 0.331, 0.121, and 0.889, respectively), indicating that these baseline characteristics did not influence the association.ConclusionsOur findings indicated an association between increased waist circumference and a higher prevalence of nocturia. Knowledge of this association reinforces the importance of lifestyle modifications in maintaining a healthy waist circumference and informs public health strategies to address other potential risk factors for nocturia.
Experimental investigation on response mechanism and impact resistance of glass fiber reinforced polymer X‐type foldcore sandwich panel subjected to low‐velocity impact experiments
Authors: Deng Yunfei , Liang Xupeng , Li Hailin , Wang Xu , Feng Zhengxing 
Published: April 2024

AbstractIn this paper, a new type of foldcore sandwich panel (tentatively called X‐type foldcore sandwich panel) is proposed by combining the X‐type corrugated sandwich panel and the Miura‐ori sandwich panel. The experimental specimens are prepared by using a glass fiber‐reinforced polymer. To systematically reveal the low‐velocity response mechanism and impact resistance of sandwich panels, a hemispherical impactor is used to impact panels. The effects of impact energy, impact position, diameter of tup, and impact mass on low‐velocity impact performance of X‐type foldcore sandwich panels are considered. The damage morphology, response process, and failure mechanism are analyzed under different working conditions. The results show that under the impact of 75 and 125 J, the impact resistance of the node is better than that of the base. Under 200 J impact, the impact resistance of the base is better than that of the node. Compared with the traditional foldcore sandwich panel, the new configuration reduces the impact resistance difference between two positions (node and base).Highlights
A new foldcore sandwich panel is proposed.
The impact effect of energy, mass, position, and tup diameter is investigated.
Damage morphology, response process, and impact resistance are analyzed.
The new structure reduces differences in impact resistance.
Polypropylene aerogel‐based composites with paraffin and MWCNTs as phase change materials
Authors: Abdolmaleki Hadi , Jafari Seyed Hassan , Golriz Mahdi , Haghgoo Majid 
Published: April 2024

AbstractThe development of energy storage materials is crucial for effective energy management. In this study, we present the creation of a composite material comprising polypropylene (PP) aerogel, paraffin, and multi‐walled carbon nanotubes (MWCNTs) as a phase change material (PCM). Our process begins with the dissolution of PP granules, serving as the foundational step. Subsequently, various antisolvents are systematically employed to induce the formation of PP gels. The process culminates in the fabrication of aerogels through the established freeze‐drying technique. Importantly, our examination of porosity highlights the significant impact of antisolvent selection on the pore structure and specific surface area of the resulting aerogels. Our weight measurements demonstrate the remarkable capacity of the lightweight PP aerogel, characterized by substantial porosity and inherent hydrophobicity, to adsorb paraffin, capturing up to five times its weight. These findings are substantiated through structural analyses, including Fourier‐transform infrared spectroscopy (FTIR) and X‐ray diffraction (XRD). Thermal analysis of the PP/PCM/MWCNTs composites reveals the achievement of the highest enthalpy, reaching 125 J g−1, representing a modest 13% reduction compared to pure paraffin. Furthermore, all samples exhibit exceptional thermal stability even after 50 thermal cycles. Notably, Xenon flash analysis (XFA) shows an approximate 800% increase in thermal conductivity compared with pure paraffin and a substantial 35% increase compared to PP/paraffin composites. In conclusion, our lightweight aerogel‐based PCM demonstrates great promise for various thermal management applications.Highlights
Cost‐effective PP aerogel has a great potential for hosting paraffin as PCM.
The type of antisolvent could have a huge effect on PP aerogel's structure.
PP aerogel/Paraffin/MWCNT could effectively enhance thermal conductivity.
Available PP/Paraffin/MWCNT has a great potential for PCM applications.
Turkish adolescents' anonymous use of social networking sites (SNSs): A phenomenological study
Authors: Çimşir Elif , Akdoğan Ramazan , Akbayrak Alper 
Published: April 2024

AbstractDespite the surging anonymous social media use among adolescents living in non‐Western countries, such as Turkey, existing studies have been conducted in a Western context and do not provide a holistic understanding of adolescents' lived experiences of anonymous social networking site (SNS) interactions. As a result, Turkish adolescents aged 12–15 years (N = 20) were interviewed about their lived experiences of anonymous SNS interactions, using a phenomenological qualitative approach. The authors identified 10 themes. Four themes address circumventing social norms and avoiding repercussions: mocking friends, seeking revenge, engaging in activism, and exploring and expressing self. Four themes pertain to initiating, developing, and testing relationships: exploring romantic relationships, testing friendships, seeking information about others, and gaining attention and/or popularity. Reflecting a major intrapersonal dynamic, another theme describes low self‐confidence/esteem. The final theme addresses a significant risk associated with the anonymous use of SNSs: increased risk of child sexual exploitation. The results provide important insights into the roles of anonymous online interactions in satisfying adolescents' developmental needs and indicate the importance of providing them with support and education to help them navigate the online world safely and responsibly.
Population pharmacokinetics of intraperitoneal irinotecan and SN‐38 in patients with peritoneal metastases from colorectal origin
Authors: Rietveld Pascale C. S. , Sassen Sebastiaan D. T. , Guchelaar Niels A. D. , van Eerden Ruben A. G. , de Boer Nadine L. , van den Heuvel Teun B. M. , Burger Jacobus W. A. , Mathijssen Ron H. J. , Koch Birgit C. P. , Koolen Stijn L. W. 
Published: April 2024

AbstractPeritoneal metastases (PM) are common in patients with colorectal cancer. Patients with PM have a poor prognosis, and for those who are not eligible for cytoreductive surgery (CRS) with or without hyperthermic intraperitoneal chemotherapy (HIPEC), palliative chemotherapy is currently the only option. Recently, we conducted a phase I trial (INTERACT) in which irinotecan was administered intraperitoneally (IP) to 18 patients ineligible for CRS‐HIPEC. The primary objective was to evaluate covariates influencing the PK profile of irinotecan and SN‐38 after IP administration. Secondly, a population PK model was developed to support the further development of IP irinotecan by improving dosing in patients with PM. Patients were treated with IP irinotecan every 2 weeks in combination with systemic FOLFOX‐bevacizumab. Irinotecan and SN‐38 were measured in plasma (588 samples) and SN‐38 was measured in peritoneal fluid (267 samples). Concentration‐Time data were log‐transformed and analyzed using NONMEM version 7.5 using FOCE+I estimation. An additive error model described the residual error, with inter‐individual variability in PK parameters modeled exponentially. The final structural model consisted of five compartments. Weight was identified as a covariate influencing the SN‐38 plasma volume of distribution and GGT was found to influence the SN‐38 plasma clearance. This population PK model adequately described the irinotecan and SN‐38 in plasma after IP administration, with weight and GGT as predictive factors. Irinotecan is converted intraperitoneal to SN‐38 by carboxylesterases and the plasma bioavailability of irinotecan is low. This model will be used for the further clinical development of IP irinotecan by providing dosing strategies.
A mechanistic review on growing multiple therapeutic applications of lutein and its global market research
Authors: Akkewar Ashish Sunil , Mishra KM Abha , Kamble Mahesh Gopichand , Kumar Sanjay , Dey Juhi , Sethi Kalyan Kumar 
Published: April 2024

AbstractLutein is a naturally occurring carotenoid synthesized by plants and algae that has a beneficial effect on several biological processes and associated ailments. Its immediate application is in ophthalmology, where it significantly lowers the incidences of age‐related macular degeneration (AMD). It also has anti‐inflammatory action, treatment of diabetic retinopathy, and cataracts, and enhancement of visual contrast. To critically assess lutein biosynthesis, therapeutic applicability, and market research literature. We have discussed its theoretical frameworks, experimental evidence, limitations, as well as clinical trial results, and future research prospects. The literature for this review article was mined and compiled by collecting and analyzing articles from several databases, including ScienceDirect, Google Scholar, PubMed, Wiley Online Library, Patentscope, and ClinicalTrials.gov published until March 30, 2022. Patent publications were identified using the search terms like IC:(C07C67/56) AND EN_AB:(lutein) OR EN_TI:(lutein) OR EN_AB:(extraction) OR EN_TI:(process). According to the literature, lutein is an essential nutrient given that it cannot be synthesized in the human body and acts as an antioxidant, affecting AMD, diabetic retinopathy, Rheumatic diseases, inflammation, and cancer. Due to inadequate production and laborious extraction, lutein is expensive despite its high demand and applicability. Market research predicts a 6.3% compound annual growth rate for lutein by 2032. Optimizing lutein extraction for high yield and purity is necessary. Lutein has proven applicability in various ailments as well as cosmetics that can be developed as a candidate drug for various diseases discussed in the review.
Passive immunotherapies for the next influenza pandemic
Authors: Focosi Daniele , Franchini Massimo , Senefeld Jonathon W. , Joyner Michael J. , Sullivan David J. , Pekosz Andrew , Maggi Fabrizio , Casadevall Arturo 
Published: April 2024

AbstractInfluenzavirus is among the most relevant candidates for a next pandemic. We review here the phylogeny of former influenza pandemics, and discuss candidate lineages. After briefly reviewing the other existing antiviral options, we discuss in detail the evidences supporting the efficacy of passive immunotherapies against influenzavirus, with a focus on convalescent plasma.