bluuebunny/crossref_metadata_2025_split huggingface dataset:
Solution for Microclimate Control of Glass Greenhouse Crops via Computational Fluid Dynamics
Authors: Shang Lin-Yuan , Li Tian-Ci , Gao Yu-Xiang , Ye Wei-Bin , Qi Li-Mei , Niu Rong , Si Chun-Jing 
Published: March 2024

Abstract
Glass greenhouse agriculture is becoming increasingly crucial as a sustainable method of food production, particularly because of the effects of extreme climate change on traditional forms of agriculture. However, the current research methods fail to consider the microclimatic conditions of temperature and wind speed within the crop canopy, causing an inadequate assessment of the crop growing environment and subsequently affecting crop growth and yield. In this study, an optimal microclimate scheme for crop growth in a glass greenhouse was designed based on computational fluid dynamics (CFD) considering the effects of fan position, initial speed, and initial temperature. First, the effects of crop presence and absence on wind speed and temperature in a glass greenhouse were analyzed using CFD. Second, the most effective crop growth strategy was determined by adjusting the heater fan speed and fan position. Finally, based on key factors such as the location of the greenhouse fan, initial wind speed, and initial temperature, the optimal fan control scheme for cucumber growth was developed as an example. The experimental results showed that (1) raising the greenhouse fan to 1.4 m ensured sufficient air flow in the crop canopy at 0.5 m and in the interior area at 0.1 m, (2) increasing the initial speed of the greenhouse fan to 3.5 m/s ensured that the wind speed in the crop canopy and the interior area met the optimal growth requirements of 0.3-1 m/s, (3) adjusting the initial temperature of the greenhouse fan to 300.15 K can reduce the overall temperature to a level more favorable for crop growth. Thus, a detailed optimization analysis of the greenhouse environment and adjustments to fan design to meet the specific growth requirements of the crop provide an effective method for improving greenhouse agricultural production conditions.
A Robust Reliable Low-power High Throughput Data Collection Wireless Sensor Network
Authors: Liu Jinzhi , Jiang Zhenhua , Lin kaien 
Published: March 2024

Abstract
This paper presents a robust data gathering protocol for wireless sensor network applications that require high throughput, reliability, and low-power.
Insofar as high throughput is concerned, TDMA is more suitable than CSMA.
Efficient TDMA protocols require solid synchronization and more optimized time slot scheduling.
Reliable data collection calls for end-to-end packet retransmission.
Such factors hinder the implementation of a comprehensive data collection protocol.
In this paper, a heuristic TDMA scheduling algorithm is provided to achieve optimized time slot scheduling with multi-channel communication.
The combination of TDMA and multi-channel communication affords to sustain high throughput and low-power communication.
In addition, this paper leverages constructive interference based flooding to provide robust synchronization and efficient downward communication.
Therefore, we are able to associate constructive interference based flooding with packet retransmission to implement collection reliability.
The proposed protocol is implemented on self-made sensor node with Contiki operating system.
Experimental results in a deployed network consisting of 29 self-made sensor nodes show that the protocol is able to maintain lasting operation and provide throughput as high as 14.74 KByte/s with 100\% data collection.
The Involvement of Gas6/sAXL Signaling Pathway in Patients with Idiopathic Granulomatous Mastitis
Authors: Carkit Sedat , Ozel Merve , Oz Bahadir , Mustafa gok , Akcan Alper , Demiray Sevil , Akgun Hulya , Baskol Gulden 
Published: March 2024

Abstract

Background:Idiopathic granulomatous mastitis (IGM) is an uncommon, benign, chronic inflammatory breast disease. There are several hypotheses about the etiology of IGM. The interaction between growth arrest-specific protein 6 (Gas6)/Tyro, AXL, and Mer (TAM) affects the regulation of innate immune reactions and promotes the induction of phagocytosis and a reduction in proinflammatory cytokine expression. We analyzed the potential implications of the Gas6/sAXL signaling pathway, which is essential for the inflammatory response to the pathophysiology of IGM, the cause of which is yet unknown.
Methods: This study included 37 patients. Nineteen of these patients achieved a complete response solely through medical treatment (Group R), while the remaining 18 comprised individuals who, following medical treatment, did not achieve a complete response and necessitated supplementary surgery (Group NR). Logistic regression analysis was used to define predictive factors. The optimal cutoff values of the predictive prognostic factors for resistance to treatment were identified using receiver operating characteristic (ROC) curve analysis.
Results: No significant differences were detected between the two groups in terms of lesion size, age, parity, attack frequency, white blood cell count, presence of accompanying axillary lymphadenopathy (LAP), or smoking history (p>0.05). Significant differences were detected in terms of Gas6, sAXL, and the presence of accompanying abscess (p<0.05).
Conclusions:Decreased Gas6 and sAXL levels can be explained by two mechanisms. Inflammation may have developed due to Gas6 deficiency. The finding that low Gas6 levels are an independent risk factor for IGM treatment resistance will be a new method for treating this disease.
Do educational interventions reduce the gender gap in communication skills?- A systematic review
Authors: Driscoll Alexis M. , Suresh Rohan , Popa George , Berglund Leif , Azer Amanda , Hed Helen , Duan Yajie , Chu Alice , McGrath Aleksandra 
Published: March 2024

Abstract

Background: Efficient doctor-patient communication is essential for improving patient care. The impact of educational interventions on the communication skills of male and female students has not been systematically reviewed. The aim of this review is to identify interventions used to improve communication skills in medical curricula and investigate their effectiveness in improving the communication skills of male and female medical students.
Methods: A systematic review of the literature was conducted using the PRISMA guidelines. Inclusion criteria were as follows: used intervention strategies aiming to improve communication skills, participants were medical students, and studies were primary research studies, systematic reviews, or meta-analyses.
Results: 2913 articles were identified based on search terms. After title, abstract, and full-text review, 58 studies were included with interventions consisting of training or acting courses, curriculum-integrated, patient-interactive experiences, and community-based interventions. 69% of articles reported improved communication skills for both genders equally, 28% for women more than men, and 3% for men more than women. 16 of the 58 articles reported numerical data regarding communication skills pre-and post-intervention. Analysis revealed that post-intervention scores are significantly greater than pre-intervention scores for both male (p<0.001) and female students (p<0.001). While the post-test scores of male students were significantly lower than that of female students (p=0.01), there is no significant difference between genders for the benefits, or difference between post-intervention and pre-intervention scores (p=0.15), suggesting that both genders benefited equally.
Conclusion: Implementation of communication training into medical education will lead to increased overall medical student communication irrespective of gender. No specific interventions benefitting male students have been identified from published literature, suggesting need of further studies to explore the phenomenon of gender gap in communication skills and how to minimize the differences between male and female students.
Antibody blockade of the PSGL-1 immune checkpoint enhances T-cell responses to B-cell lymphoma
Authors: Pereira João , Ferreira Francisca , Matos Andreia , Pereira Dulcineia , Santos Rita , Carmo Alexandre , Oliveira Maria , Machado José Carlos , Santos Nuno Rodrigues dos 
Published: March 2024

Abstract

Despite advancements in cancer immunotherapy, most lymphomas remain unresponsive to checkpoint inhibitors. P-selectin glycoprotein ligand-1 (PSGL-1), recently identified as a promoter of T cell exhaustion in melanoma murine models, has emerged as a novel immune checkpoint protein and promising immunotherapeutic target. In this study, we investigated the potential of PSGL-1 antibody targeting in B-cell lymphoma. Using allogeneic coculture systems, we demonstrated that targeted antibody interventions against human PSGL-1 resulted in enhancement of T cell activation and effector cytokine production in response to lymphoma cells. Moreover, in vitro treatment of primary lymphoma cell suspensions with PSGL-1 antibody resulted in increased activation of autologous lymphoma-infiltrating T cells. Finally, using a syngeneic B-cell lymphoma mouse model, we found that PSGL-1 antibody treatment significantly slowed tumor development and reduced endpoint tumor burden. This anti-tumoral action was accompanied by augmented tumor infiltration with CD4+ and CD8+ T cells and reduced infiltration with regulatory T cells. These results demonstrate that PSGL-1 antibody blockade bolsters T-cell activity against B-cell lymphoma, suggesting a potential novel immunotherapeutic approach to treat these malignancies.
Exploring the reasons for wanting a peer partner to be physically active among women living with and beyond a cancer diagnosis: A content analysis
Authors: O’Rourke Roxy H. , Vani Madison F. , O’Loughlin Erin K. , Thibodeau Delaney , Sabiston Catherine M. 
Published: March 2024

Abstract

Background: Initiating and maintaining exercise is challenging for women during and post-cancer treatment. Adopting a peer partner model to provide social support to be active may contribute to lasting behaviour change of both partners. Despite this, finding a ‘like peer’ can be challenging.
Purpose: To explore women’s reasons for seeking an online exercise partner following a diagnosis with cancer (through www.activematch.ca). We also examined women’s potential socio-demographic and cancer-related differences by reported reasons for wanting an exercise partner.
Methods: Individuals creating an Active Match profile completed demographic and physical activity questions (N=199, Mage(SD)=51.9(10.8) years), including an open-ended question regarding their ‘reason for wanting an exercise partner’. An inductive content analysis was completed focusing on the participants’ peer exercise partner preferences. Additional chi-square tests were run to assess whether participants differed based on sociodemographic and cancer-related characteristics and their motivations to be active by category of ‘reason for wanting an exercise partner’ endorsed in the open-ended question.
Results: The participants’ reasons for wanting an exercise partner were coded into seven categories, with most participants highlighting the reasons of: motivation (52.3%), social support (48.7%), and accountability and adherence (26.6%). Women <50 years of age were more likely to report accountability and adherence related preferences for a partner. Those reporting endorsing weight loss as their primary reason for becoming active were more likely to be categorized as wanting a peer partner for motivation.
Conclusions: While finding a peer partner can be challenging, matching women living with and beyond a cancer diagnosis based on their reason for wanting an exercise partner, as well as their reasons for wanting to be active, may be important to build successful peer exercise partnerships.
Cognitive enrichment through art: a randomized controlled trial on the effect of music or visual arts group practice on cognitive and brain development of young children
Authors: James Clara E. , Tingaud Maxim , Laera Gianvito , Guedj Carole , Zuber Sascha , Palazzi Raffaello Diambrini , Vukovic Stoja , Richiardi Jonas , Kliegel Matthias , Marie Damien 
Published: March 2024

Abstract

Background
The optimal stimulation for brain development in the early academic years remains unclear. Current research suggests that musical training has a more profound impact on children's executive functions (EF) compared to other art forms. What is crucially lacking is a large-scale, long-term genuine randomized controlled trial (RCT) in cognitive neuroscience, comparing musical instrumental training (MIP) to another art form, and a control group (CG). This study aims to fill this gap by using machine learning to develop a multivariate model that tracks the interconnected brain and EF development during the academic years, with or without music or other art training.
Methods
The study plans to enroll 150 children aged 6-8 years and randomly assign them to three groups: Orchestra in Class (OC), Visual Arts (VA), and a control group (CG). Anticipating a 30% attrition rate, each group aims to retain at least 35 participants. The research consists of three analytical stages: 1) baseline analysis correlating EF, brain data, age, gender, and socioeconomic status, 2) comparison between groups and over time of EF brain and behavioral development, including hypothesis testing, and 3) exploratory analysis combining behavioral and brain data. The intervention includes intensive art classes once a week, and incremental home training over two years, with the CG receiving six annual cultural outings.
Discussion
This study examines the potential benefits of intensive group arts education, especially contrasting music with visual arts, on EF development in children. It will investigate how artistic enrichment potentially influences the presumed typical transition from a more unified to a more multifaceted EF structure around age eight, comparing these findings against a minimally enriched active control group. This research could significantly influence the incorporation of intensive art interventions in standard curricula.
Trial registration
The project was accepted after peer-review by the Swiss National Science Foundation (SNSF no. 100014_214977) on March 29, 2023. The study protocol received approval from the Cantonal Commission for Ethics in Human Research of Geneva (CCER, BASEC-ID 2023-01016), which is part of Swiss ethics, on October 25, 2023. The study is registered at clinicaltrials.gov (NCT05912270).
Prehospital guidelines on in-water traumatic spinal injuries for lifeguards and prehospital Emergency Medical Services: an international Delphi consensus study
Authors: Breindahl Niklas , Bierens Joost L M , Wiberg Sebastian , Barcala-Furelos Roberto , Maschmann Christian 
Published: March 2024

Abstract

Background
Trauma guidelines on spinal motion restriction (SMR) have changed drastically in recent years. An international group of experts explored whether consensus could be reached and if guidelines on SMR performed by trained lifeguards and prehospital EMS following in-water traumatic spinal cord injury (TSCI) should also be changed.
Methods
An international three-round Delphi process was conducted from October 2022 to November 2023. In Delphi round one, brainstorming resulted in an exhaustive list of recommendations for handling patients with suspected in-water TSCI. The list was also used to construct a preliminary flowchart for in-water SMR. In Delphi round two, three levels of agreement for each recommendation and the flowchart were established. Recommendations with strong consensus (≥ 85% agreement) underwent minor revisions and entered round three; recommendations with moderate consensus (75–85% agreement) underwent major revisions in two consecutive phases; and recommendations with weak consensus (< 75% agreement) were excluded. In Delphi round 3, the level of consensus for each of the final recommendations and each of the routes in the flowchart was tested using the same procedure as in Delphi round 2.
Results
Twenty-four experts participated in Delphi round one. The response rates for Delphi rounds two and three were 92% and 88%, respectively. The study resulted in 25 recommendations and one flowchart with four flowchart paths; 24 recommendations received strong consensus (≥ 85%), and one recommendation received moderate consensus (81%). Each of the four paths in the flowchart received strong consensus (90–95%). The integral flowchart received strong consensus (93%).
Conclusions
This study produced expert consensus on 25 recommendations and a flowchart on handling patients with suspected in-water TSCI by trained lifeguards and prehospital EMS. These results provide clear and simple guidelines on SMR, which can standardise training and guidelines on SMR performed by trained lifeguards or prehospital EMS.
Right frontal gamma transcranial alternating current stimulation modulates optimism biases
Authors: Yao Ziqing , Wei Jinwen , Huang Gan , Li Linling , Liang Zhen , Zhang Li , Wu Haiyan , Yuan Tifei , Zhang Zhiguo , Hu Xiaoqing 
Published: March 2024

Abstract

Background
When forecasting the future, people often underestimate the likelihood of adverse life events, a phenomenon known as optimism bias. While transcranial alternating current stimulation (tACS) over frontal regions has been employed to modulate various cognitive and emotional functions, its potential impact on optimism bias remains unexplored.
Results
Using a single-blind, sham-controlled, between-subjects design, we investigated the effects of alpha- and gamma-tACS on optimism bias. Three groups of participants received 15-min of either individualized alpha frequency (IAF)-tACS, 40 Hz-tACS, or sham stimulation over the right frontal cortex during rest. To assess how tACS impacted the optimism bias, participants completed a belief update task before and immediately after the tACS. To assess potential delayed effect of the tACS, participants completed a delay estimation task 24 hours later. We found that across all three groups, participants showed the classic optimism bias, such that they were more likely to update their beliefs toward desirable than undesirable feedback. Notably, compared to the sham and IAF-tACS groups, 40 Hz-tACS further enhanced optimism biases after 24 hours.
Conclusion
These findings suggest that right frontal gamma- but not alpha-tACS could effectively modulate the long-term optimistic belief updating. Our study highlights the potential of non-invasive brain stimulation as a promising tool for altering optimism biases, which may benefit individuals with pessimistic outlooks.
UBI29-41-targeted, NIR-triggered nanoparticles for enhanced PDT against periodontal plaque biofilm formation and immunomodulation
Authors: Li Wen , You Fengqun , Bao Han , Yang Jie , Gu Deao , Li Yuyang , Zhang Xuan , Liu Chao , Miao Leiying , Sun Weibin 
Published: March 2024

Abstract
Periodontitis, a prevalent inflammatory disease affecting the oro-maxillofacial region, is induced by dental plaque biofilms. Periodontitis not only causes the degradation of supporting periodontal tissues but also poses a significant threat to overall health. The distinctive architecture of biofilms renders conventional mechanical debridement and antibiotic treatment ineffective against them. To overcome this problem, in this study, we successfully developed a multifunctional nanocomposite that combines antimicrobial peptides with photodynamic therapy (PDT) to selectively exert antimicrobial and anti-inflammatory effects. Our findings show that under 808-nm single-wavelength near-infrared light irradiation, the cationic antimicrobial peptide UBI29-41 not only enhances the efficacy of antibacterial PDT in specifically inhibiting the formation of periodontal biofilm by binding to lipopolysaccharide (LPS) and lipoteichoic acid (LTA) on the surface of bacteria through electrostatic interactions. Additionally, the targeting effect of UBI29-41 on LPS inhibits IκBα phosphorylation and NF-κB signaling pathway activation, ultimately exerting anti-inflammatory effects. We confirmed our in vivofindings in a rat periodontitis model and also demonstrated efficacy of the nanoparticles in inhibiting the degradation of collagen in gingival tissue, which enabled the successful treatment of periodontal disease. Hence, this study offers a novel strategy for the precise treatment of periodontal disease, including the management of deeply infected tissues.
Spacing-adjustable and switchable multi-wavelength erbium-doped fiber laser using the filter of MMF-PMF-MMF based on PHB
Authors: Zhang Weihua , Liu Xinbo , Shi Yanmei , Tong Zhengrong , Wang Hao , Wang Xue 
Published: March 2024

Abstract

A spacing-adjustable and switchable multi-wavelength erbium-doped fiber laser is proposed and analyzed based on the polarization hole burning (PHB) effect. The comb filter consists of multimode fiber - polarization maintaining fiber - multimode fiber (MMF-PMF-MMF). Here the filter is used as the polarization-dependent element to induce the polarization hole burning (PHB) effect. The filter is placed in the laser cavity or embedded into the Sagnac loop. By adjusting the polarization controller (PC) in the cavity, when the filter is placed in the laser cavity, the output wavelengths can be switched from single-wavelength to sextuple-wavelength, and dual-, triple-, quad-, quintuple- and sextuple-wavelength with adjustable wavelength spacing can be obtained. The dual-wavelength has a substantial amount of wavelength spacing adjustability with the range of 3.32 nm to 30.16 nm. When the filter is embedded into the Sagnac loop, the wavelength tuning ranges for single-, dual-, triple- and quad-wavelength are 28.42 nm, 28.10 nm, 18.21 nm and 14.58 nm, respectively. The proposed erbium-doped fiber laser (EDFL) provides a wide range of wavelengths and adjustable spacing, which is suitable for a variety of applications such as optical communication, optical detection and optical signal processing.