bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radical surgical resection with molecular margins is associated with improved survival in IDH wild-type glioblastoma
Authors: Massaad Elie , Smith William J , Bradley Joseph , Esposito Eric , Gupta Mihir , Burns Evan , Burns Ryan , Velarde José K , Berglar Inka K , Gupta Rajiv , Martinez-Lage Maria , Dietrich Jorg , Lennerz Jochen K , Dunn Gavin P , Jones Pamela S , Choi Bryan D , Kim Albert E , Frosch Matthew , Barker Fred G , Curry William T , Carter Bob S , Nahed Brian V , Cahill Daniel P , Shankar Ganesh M 
Published: April 2024

Abstract

Background
Survival is variable in patients with glioblastoma IDH wild-type (GBM), even after comparable surgical resection of radiographically detectable disease, highlighting the limitations of radiographic assessment of infiltrative tumor anatomy. The majority of postsurgical progressive events are failures within 2 cm of the resection margin, motivating supramaximal resection strategies to improve local control. However, which patients benefit from such radical resections remains unknown.

Methods
We developed a predictive model to identify which IDH wild-type GBMs are amenable to radiographic gross-total resection (GTR). We then investigated whether GBM survival heterogeneity following GTR is correlated with microscopic tumor burden by analyzing tumor cell content at the surgical margin with a rapid qPCR-based method for detection of TERT promoter mutation.

Results
Our predictive model for achievable GTR, developed on retrospective radiographic and molecular data of GBM patients undergoing resection, had an area under the curve of 0.83, sensitivity of 62%, and specificity of 90%. Prospective analysis of this model in 44 patients found that 89% of patients were correctly predicted to achieve a residual volume (RV) &lt; 4.9cc. Of the 44 prospective patients undergoing rapid qPCR TERT promoter mutation analysis at the surgical margin, 7 had undetectable TERT mutation, of which 5 also had a GTR (RV &lt; 1cc). In these 5 patients at 30 months follow-up, 75% showed no progression, compared to 0% in the group with TERT mutations detected at the surgical margin (P = .02).

Conclusions
These findings identify a subset of patients with GBM that may derive local control benefits from radical resection to undetectable molecular margins.
Mycotoxins and bone growth: a review of the literature on associations between xenobiotic exposure and bone growth and development
Authors: Mehta Rukshan , Wenndt Anthony J 
Published: April 2024

Abstract
Mycotoxins are secondary metabolites of fungi that are known to be associated with linear growth faltering because of their impact on inflammation, intestinal damage, inhibition of protein synthesis, and micronutrient absorption. In this narrative review, we aim to extend this analysis to further explore associations between mycotoxins (aflatoxins, ochratoxins, trichothecenes including deoxynivalenol, T-2 toxin, and fumonisins) and long-bone growth, particularly during the saltatory periods of development. Linear growth is a direct function of skeletal development and long-bone growth. We therefore explored biological pathways and mechanisms of impact of these toxins in both animal and human studies, in addition to the epidemiology literature (post-2020). Given what is known of the effects of individual and combinations of mycotoxins based on the animal literature, we have identified a need for further research and examination of how these toxins and exposures may be studied in humans to elucidate the downstream impact on bone-related biomarkers and anthropometric indices used to identify and predict stunting in population-based studies.
Recent Advances in the Crosstalk between Brassinosteroids and Environmental Stimuli
Authors: Zhao Yuqing , Han Qing , Zhang Dawei 
Published: April 2024

Abstract
Due to their sessile lifestyle, plants need to optimize their growth in order to adapt to ever-changing environments. Plants receive stimuli from the environment and convert them into cellular responses. Brassinosteroids (BRs), as growth-promoting steroid hormones, play a significant role in the tradeoff between growth and environmental responses. Here, we provide a comprehensive summary for understanding the crosstalk between BR and various environmental stresses, including water availability, temperature fluctuations, salinization, nutrient deficiencies and diseases. We also highlight the bottlenecks that need to be addressed in future studies. Ultimately, we suppose to improve plant environmental adaptability and crop yield by excavating natural BR mutants or modifying BR signaling and its targets.
The 2024 Taiwanese Presidential Election on social media: Identity, policy, and affective virality
Authors: Chang Ho-Chun Herbert , Fang Yu Sunny 
Published: April 2024

Abstract
The 2024 Taiwanese Presidential Election is not just a critical geopolitical event, it also engages with themes of alternative candidacy, foreign policy, and affective polarization. At one point, a four-candidate race had emerged in a traditionally bipartisan election, with alternative candidates disrupting the dichotomy of Chinese vs. Taiwanese identity. Leveraging 911,510 posts and 101,600,047 engagements on social media, we analyze user discourse and engagement. First, we find traditional candidates derive more engagement on foreign policy and geopolitical issues, alternative candidates on domestic issues. Additionally, virality is generated by affective reasons, although in-group references generate more engagement than out-group references. Lastly, a puzzle is revealed where alternative candidates draw more homogeneous attention from national identity groups. Results suggest alternative candidacy can be generated by both positive and negative comparisons rooted in national identity.
Leveraging video evidence in domestic violence misdemeanour cases: Examination of case dispositions and case length
Authors: Backes Bethany L , Masters Mackenzie , Roman Krystle , Wasim Anna , Wood Leila 
Published: April 2024

Abstract
Law enforcement has used video recording devices (e.g. dash camera, body-worn camera) for more than 40 years, with body-worn cameras emerging in 2005 as a policing tool. However, little is known regarding how video evidence is leveraged in case decision-making and outcomes for domestic violence. Law enforcement may use cameras to enhance evidence collection in domestic violence cases, take statements from victims, witnesses, and offenders, record injuries and damages, and document the administration of risk/injury assessments. Preliminary research has indicated video evidence may have strong evidentiary value in domestic violence cases, however, has rarely controlled for other contributing factors. This study furthers our knowledge by examining how video evidence taken by law enforcement impacts case outcomes and length of time to disposition in a sample of closed, misdemeanour domestic violence cases within a large county in a southwestern state. A random sample of cases (n = 612) with and without video evidence were examined for differences in case disposition and case length. Additional evidentiary factors and case characteristics are considered such as prior criminal charges, victim–offender relationship, presence of non-video evidence, presence of witnesses, and gender of offender. Analyses indicate significant differences, such that cases with video evidence are associated with increased guilty pleas, increased convictions, and less time to closure/final case disposition. Findings have implications for the use of video evidence in strengthening the criminal justice response to domestic violence incidents in combination with other case factors.
Higher-degree Artin conjecture
Authors: Järviniemi Olli 
Published: April 2024

ABSTRACT
For an algebraic number α we consider the orders of the reductions of α in finite fields. In the case where α is an integer, it is known by the work on Artin’s primitive root conjecture that the order is ‘almost always almost maximal’ assuming the Generalized Riemann Hypothesis (GRH), but unconditional results remain modest. We consider higher-degree variants under GRH. First, we modify an argument of Roskam to settle the case where α and the reduction have degree two. Second, we give a positive lower density result when α is of degree three and the reduction is of degree two. Third, we give higher-rank results in situations where the reductions are of degree two, three, four or six. As an application we give an almost equidistribution result for linear recurrences modulo primes. Finally, we present a general result conditional to GRH and a hypothesis on smooth values of polynomials at prime arguments.
HKT Manifolds: Hodge Theory, Formality and Balanced Metrics
Authors: Gentili Giovanni , Tardini Nicoletta 
Published: April 2024

ABSTRACT
Let $(M,I,J,K,\Omega)$ be a compact HKT manifold, and let us denote with $\partial$ the conjugate Dolbeault operator with respect to I, $\partial_J:=J^{-1}\overline\partial J$, $\partial^\Lambda:=[\partial,\Lambda]$, where Λ is the adjoint of $L:=\Omega\wedge-$. Under suitable assumptions, we study Hodge theory for the complexes $(A^{\bullet,0},\partial,\partial_J)$ and $(A^{\bullet,0},\partial,\partial^\Lambda)$ showing a similar behavior to Kähler manifolds. In particular, several relations among the Laplacians, the spaces of harmonic forms and the associated cohomology groups, together with Hard Lefschetz properties, are proved. Moreover, we show that for a compact HKT $\mathrm{SL}(n,\mathbb{H})$-manifold, the differential graded algebra $(A^{\bullet,0},\partial)$ is formal and this will lead to an obstruction for the existence of an HKT $\mathrm{SL}(n,\mathbb{H})$ structure $(I,J,K,\Omega)$ on a compact complex manifold (M, I). Finally, balanced HKT structures on solvmanifolds are studied.
Patients with NPSLE experience poorer HRQoL and more fatigue than SLE patients with no neuropsychiatric involvement, irrespective of neuropsychiatric activity
Authors: Nikolopoulos Dionysis , Cetrez Nursen , Lindblom Julius , Palazzo Leonardo , Enman Yvonne , Parodis Ioannis 
Published: April 2024

Abstract

Objectives
Substantial proportions of patients with SLE report poor health-related quality of life (HRQoL). Our objective was to investigate the impact of neuropsychiatric involvement (NP) in SLE on patient-reported outcomes.

Methods
We analysed data from four phase III trials (BLISS-52, BLISS-76, BLISS-SC, EMBRACE; N = 2968). The NPSLE group comprised individuals with NP-BILAG A/B/C/D or score in any descriptor of the NP-SLEDAI-2K at baseline (N = 350), while the non-NPSLE group consisted of patients with NP-BILAG E (N = 2618). HRQoL was assessed with the SF-36, EQ-5D-3L, and FACIT-F. Full health state (FHS) was defined as ‘no problems’ in all EQ-5D dimensions.

Results
NPSLE patients reported lower scores in the SF-36 physical and mental component summary compared with the non-NPSLE population [mean (s.d.): 35.7 (9.1) vs 39.6 (9.6); P &lt; 0.001 and 37.3 (12.1) vs 41.4 (11.0); P &lt; 0.001, respectively]. NPSLE patients also exhibited impaired HRQoL in all EQ-5D dimensions compared with non-NPSLE patients (P &lt; 0.05 for all). A substantially lower proportion of NPSLE patients experienced FHS in comparison with the non-NPSLE group (3.3% vs 14.5%; P &lt; 0.001). NPSLE was associated with severe fatigue [23.8 (12.2) vs 31.5 (11.6); P &lt; 0.001]. Notably, our findings revealed no discernible distinctions between active and inactive NPSLE patients with regard to SF-36, EQ-5D, FHS or FACIT-F scores.

Conclusion
NP in patients with SLE has a detrimental effect on HRQoL experience and is associated with severe fatigue, regardless of the degree of neuropsychiatric disease activity. Early intervention is warranted in NPSLE patients to enhance long-term HRQoL experience.
Distinct Volume Alterations of Thalamic Nuclei Across the Schizophrenia Spectrum
Authors: Thalhammer Melissa , Schulz Julia , Scheulen Felicitas , Oubaggi Mohamed El Mehdi , Kirschner Matthias , Kaiser Stefan , Schmidt André , Borgwardt Stefan , Avram Mihai , Brandl Felix , Sorg Christian 
Published: April 2024

Abstract

Background and Hypothesis
Abnormal thalamic nuclei volumes and their link to cognitive impairments have been observed in schizophrenia. However, whether and how this finding extends to the schizophrenia spectrum is unknown. We hypothesized a distinct pattern of aberrant thalamic nuclei volume across the spectrum and examined its potential associations with cognitive symptoms.

Study Design
We performed a FreeSurfer-based volumetry of T1-weighted brain MRIs from 137 healthy controls, 66 at-risk mental state (ARMS) subjects, 89 first-episode psychosis (FEP) individuals, and 126 patients with schizophrenia to estimate thalamic nuclei volumes of six nuclei groups (anterior, lateral, ventral, intralaminar, medial, and pulvinar). We used linear regression models, controlling for sex, age, and estimated total intracranial volume, both to compare thalamic nuclei volumes across groups and to investigate their associations with positive, negative, and cognitive symptoms.

Study Results
We observed significant volume alterations in medial and lateral thalamic nuclei. Medial nuclei displayed consistently reduced volumes across the spectrum compared to controls, while lower lateral nuclei volumes were only observed in schizophrenia. Whereas positive and negative symptoms were not associated with reduced nuclei volumes across all groups, higher cognitive scores were linked to lower volumes of medial nuclei in ARMS. In FEP, cognition was not linked to nuclei volumes. In schizophrenia, lower cognitive performance was associated with lower medial volumes.

Conclusions
Results demonstrate distinct thalamic nuclei volume reductions across the schizophrenia spectrum, with lower medial nuclei volumes linked to cognitive deficits in ARMS and schizophrenia. Data suggest a distinctive trajectory of thalamic nuclei abnormalities along the course of schizophrenia.
The standard form under pressure? On the ecological reconfiguration of product presentation using the example of consumables
Authors: Gajewski Eltje , Schrör Simon 
Published: April 2024

Abstract
This article provides a framework for analyzing valorizations and justifications for ecologically sustainable everyday products. By drawing on theoretical arguments from the French neo pragmatist approach of economics of conventions, especially the idea of enrichment, we develop a typology of valorizations that distinguishes between analytic and narrative presentations. A qualitative empirical analysis of green alternatives to standard consumables, such as coffee, textiles or hygiene products, is used to help explain the strategies by which sustainable products are placed and marketed. We state that sustainable product presentations use a range of established forms of valorization that also affects the justification of their often-higher prices. We conclude that the standard form of consumables comes under pressure while capitalist actors appear to incorporate the growing ecologic critique with a set of ecologic enrichments.
Museum Skins Enable Identification of Introgression Associated with Cytonuclear Discordance
Authors: Potter Sally , Moritz Craig , Piggott Maxine P , Bragg Jason G , Afonso Silva Ana C , Bi Ke , McDonald-Spicer Christiana , Turakulov Rustamzhon , Eldridge Mark D B 
Published: April 2024

Abstract
Increased sampling of genomes and populations across closely related species has revealed that levels of genetic exchange during and after speciation are higher than previously thought. One obvious manifestation of such exchange is strong cytonuclear discordance, where the divergence in mitochondrial DNA (mtDNA) differs from that for nuclear genes more (or less) than expected from differences between mtDNA and nuclear DNA (nDNA) in population size and mutation rate. Given genome-scale data sets and coalescent modeling, we can now confidently identify cases of strong discordance and test specifically for historical or recent introgression as the cause. Using population sampling, combining exon capture data from historical museum specimens and recently collected tissues we showcase how genomic tools can resolve complex evolutionary histories in the brachyotis group of rock-wallabies (Petrogale). In particular, applying population and phylogenomic approaches we can assess the role of demographic processes in driving complex evolutionary patterns and assess a role of ancient introgression and hybridization. We find that described species are well supported as monophyletic taxa for nDNA genes, but not for mtDNA, with cytonuclear discordance involving at least 4 operational taxonomic units across 4 species which diverged 183–278 kya. ABC modeling of nDNA gene trees supports introgression during or after speciation for some taxon pairs with cytonuclear discordance. Given substantial differences in body size between the species involved, this evidence for gene flow is surprising. Heterogenous patterns of introgression were identified but do not appear to be associated with chromosome differences between species. These and previous results suggest that dynamic past climates across the monsoonal tropics could have promoted reticulation among related species.
Evaluation of ATP bioluminescence for rapid determination of cleanliness of livestock trailers after a commercial wash
Authors: Letsch Flavia G , Welch Michael W , Meyer Matthew , Hedblom Grant A , Parr Eric , Classen Dyneah M , Dillard Molly , Boler Dustin D 
Published: April 2024

Abstract
Pathogens such as porcine epidemic diarrhea virus (PEDV), porcine reproductive and respiratory syndrome (PRRSV), and E. coli are known to spread by contaminated vehicles and equipment. Pork producers have adopted trailer wash policies where each trailer is washed, disinfected, and dried before it can return to a farm. Cleanliness of livestock trailers after washing is determined by visual inspection rather than any objective method. Adenosine triphosphate (ATP) bioluminescence is used in many industries to provide real-time feedback on surface cleanliness through the detection of ATP from organic sources. That same technology may provide trailer wash facilities a way of objectively characterizing a livestock trailer’s suitability to return to a farm after washing. Two ATP luminometers (3M Clean-Trace and Neogen AccuPoint) were used to estimate the correlation between ATP bioluminescence readings and aerobic bacterial plate counts (APCs) from sampled surfaces and to determine locations within a livestock trailer that can accurately estimate surface cleanliness. Five locations in livestock trailers were evaluated. Those locations included the nose access door (NAD), back door flush gate, rear side access door (RSAD), belly flush gate (BFG), and belly side access door (BSAD). There was a positive log–log association between the two luminometers (r = 0.59, P &lt; 0.01). Every log unit increase in one unit, resulted in a 0.42 log increase (P &lt; 0.01) in the other unit. ATP can come from bacteria, yeasts, molds, and manure. There was a poor association (r ≥ 0.10, P ≥ 0.02) between APCs and the ATP luminometers. Still, an increase in relative light units (RLUs) resulted in a corresponding increase in colony-forming units. The greatest area of surface contamination measured by APC was the NAD. RLUs were also greater in the NAD compared to the RSAD, the BFG, and the BSAD (P ≤ 0.01). Because APCs and luminometer RLUs provided similar outcomes, statistical process control charts were developed to determine control limits for RLUs. This provides real-time feedback to trailer wash workers in determining cleanliness outcomes for livestock trailers. These data suggest that ATP bioluminescence can be a reliable method to monitor cleaning effectiveness in livestock trailers. Bioluminescence is a monitoring tool that should be used in conjunction with microbial methods to monitor procedures for cleaning and disinfection.
Free Trade and Subnational Development: Economic Activity and Human Welfare
Authors: Cruzatti C John 
Published: April 2024

ABSTRACT
This paper delves into the subnational relationship between free trade agreements (FTAs) and human development worldwide. Utilizing a difference-in-differences and an event-study approach with high-spatial-resolution land-cover data and a comprehensive time series of national-level FTA indicators for 207 countries, the study quantifies the effects of FTAs on subnational development. The findings indicate a small negative impact of FTAs on the Human Development Index but a notable positive impact on economic activity, with urbanized regions benefiting the most. Unequal and more vulnerable regions grapple with declining human development indicators. The depth of FTAs does not sway these outcomes. These patterns raise questions about the inclusivity and equitable distribution of the benefits of trade liberalization. While prior literature has examined the national implications of FTAs, this paper provides insight into the subnational repercussions of FTAs and emphasizes the role of inequality in hindering holistic developmental benefits from FTAs.
A Systematic Review of Psycho-Spiritual Interventions in the NICU
Authors: Brelsford Gina M. , Doheny Kim K. , Stoner Jennifer 
Published: April 2024

Background:
The presence of psychospiritual supports and interventions for neonatal intensive care unit (NICU) parents is unclear.

Purpose:
This systematic review examines the psychological and medical literature for psychospiritual interventions designed to support parents’ mental health and psychological well-being during or after the NICU experience.

Data Sources:
Data sources include PubMed, PsycINFO, and Cochrane Library (Cochrane Database of Systemic Reviews, Cochrane Central Register of Controlled Trials) with peer-reviewed studies published between 2013 and 2023.

Study Selection:
Peer-reviewed studies that included spiritual and psychological intervention components focused on supporting parents during or after the NICU were included for this systematic review. There were 42 records located in 3 databases ultimately yielding 4 peer-reviewed studies that met inclusion criteria. Articles must have been written in English and evaluate parents’/caregivers’ mental health/psychological well-being in relation to a psychospiritual intervention.

Data Extraction:
Because of the small number of studies, article summaries are provided within the results section and were written by the first author with approval by the second and third authors.

Results:
Results indicated that when psychological (focus on coping) and spiritual components were included psychological and well-being outcomes were better for NICU parents.

Implications for Practice and Research:
The inclusion of psychological and spiritual aspects of coping and supportive care is necessary for the best family-centered NICU care. More work needs to be done to develop psychospiritual supports and include fathers in these endeavors as most work occurs with mothers. Nurses need support and training to facilitate family-centered care with a focus on parents’ psychospiritual needs.