bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determining standards for professional divers diving in benzene polluted waters
Authors: Froom P 
Published: November 2008

The main objective of this study is to calculate the hours of diving in benzene-polluted waters acceptable for professional divers. We considered recommended absorption limit as that from pulmonary workplace absorption during an 8-h workday at recommended exposure limits set by the National Institute of Occupational Safety and Health, and developed a formula to determine recommended limits for diving time based on actual water and sediment concentrations and exposure conditions. The recommended absorption limit is 1.6 mg of benzene per workday. This is equivalent to total body dermal absorption over a 1-h dive at water concentration of 7.6 mg/L, or absorption from drinking 0.1 L of water with a concentration of 16.5 mg/L, or dermal absorption with 50% of the body covered in sediment with a concentration of 18,851 mg/kg. A formula that calculates allowable diving time considering benzene water and sediment concentrations, and gastrointestinal and dermal exposures is presented. Water concentrations and not exposure to sediment limit recommended diving time, and unlimited diving in areas with sediment and water concentrations thought to pose a serious human health hazard would not surpass the recommended amount of benzene absorbed in the workplace. We conclude that allowable diving time in polluted waters can be calculated resulting in absorption equivalent to recommended limits for pulmonary absorption in the workplace. Our results suggest that agencies determining significant health risk levels of chemical concentrations in sediment and water should consider our findings.
Chloroacetonitrile induces intrauterine growth restriction and musculoskeletal toxicity in fetal mouse
Authors: Ahmed AE , El-Mazar HM , Nagy AA , Abdel-Naim AB 
Published: November 2008

Chloroacetonitrile (CAN) is a by-product of chlorination of drinking water. Epidemiological studies indicate that it might present a hazard to human health. The present study was designed to investigate the potential adverse effects of intrauterine exposure to CAN on fetal body weight and development of the musculoskeletal system in mice. At gestation day 6, pregnant mice were given CAN (12.5, 25, or 50 mg/kg/day) till gestation day 18. Uteri were then examined and live fetuses were collected, weighed, and evaluated for any malformations. High doses of CAN (50 mg/kg) significantly elevated fetal anomalies and reduced fetal viability. Chloroacetonitrile at a dose of 25 mg/kg did not affect fetal viability and significantly reduced fetal body weight. Subsequent experimentation was performed using this dose level. Histological examination of fetal axial skeleton indicated that CAN resulted in delayed appearance of endochondral ossification centers, widening of the vertebrae, and destruction of the calcified zone. In addition, the skeletal muscle fibers were markedly distorted, were small in size, and were widely separated by connective tissue. Both connective tissue perimysium and endomysium were less cellular compared with control sections. The histological findings were further confirmed by assessing the morphometric changes. Ratios of calcified cartilage to non-calcified cartilage areas in both control and CAN-exposed groups were determined. Also, skeletal muscle fiber diameter of CAN-exposed fetuses was significantly decreased compared with control group. In conclusion, intrauterine exposure to low levels of CAN decreases fetal body weight and induces malformations in the musculoskeletal system in mice.
Clinical variables associated with non-dipping of nocturnal blood pressure in type 2 diabetes
Authors: Sommerfield Andrew J , Robinson Lorna , Padfield Paul L , Strachan Mark WJ 
Published: November 2008

Aim Non-dipping of nocturnal BP (blood pressure) is common in people with type 2 diabetes and is associated with increased risk of cardiovascular morbidity and mortality. This study aimed to identify the factors associated with nocturnal non-dipping of BP in people with type 2 diabetes. Methods Data were examined from 100 people with type 2 diabetes who had undergone ambulatory BP monitoring. Dippers were defined as those with a systolic night-time BP dip over 15%, and non-dippers as those with a systolic night-time BP dip of under 5%. Results There was no significant difference between the mean awake systolic BP in the dipping (142.9 mmHg) and the non-dipping (142.0 mmHg) groups (p=0.77). Non-dippers were significantly older (p<0.0001) with a higher prevalence of albuminuria (p=0.003) and of macrovascular disease (p=0.008) when compared with the dipping group. After adjustment for age, albuminuria remained more prevalent within the non-dipping group (p=0.007). There was no significant difference in glycaemic control, type of diabetes treatment, smoking status, or gender between the groups. Conclusion Albuminuria is strongly associated with non-dipping of nocturnal BP in people with type 2 diabetes.
Loss of PTEN expression is associated with colorectal cancer liver metastasis and poor patient survival
Authors: Sawai Hirozumi , Yasuda Akira , Ochi Nobuo , Ma Jiachi , Matsuo Yoichi , Wakasugi Takehiro , Takahashi Hiroki , Funahashi Hitoshi , Sato Mikinori , Takeyama Hiromitsu 
Published: November 2008

Abstract

Background
The tumour suppressor phosphatase and tensin homolog (PTEN) is an important negative regulator of cell-survival signaling. To evaluate the correlation between PTEN expression and clinicopathological characteristics of colorectal cancer patients with and without liver metastases, we investigated PTEN expression in primary colorectal cancer and colorectal cancer liver metastases.

Methods
Sixty-nine pairs of primary colorectal cancer and corresponding liver metastasis specimens were analyzed immunohistochemically, and the correlation between immunohistochemical findings and clinicopathological factors was investigated. Seventy primary colorectal cancer specimens from patients without liver metastases were used as controls.

Results
PTEN was strongly expressed in 44 (62.9%) colorectal cancer specimens from patients without liver metastases. In contrast, PTEN was weakly expressed in 52 (75.4%) primary colorectal cancer specimens from patients with liver metastases, and was absent in liver metastases. Weak PTEN expression in colorectal cancer tissues was significantly associated with advanced TNM stage (p < 0.01) and lymph node metastasis (p < 0.05). PTEN expression was significantly stronger in primary colorectal cancer specimens from patients without liver metastases. Furthermore, among colorectal cancer patients with liver metastases, the 5-year survival rate was significantly higher in patients with positive PTEN expression compared to those with negative PTEN expression (p = 0.012).

Conclusion
Our results suggest that loss of PTEN expression is involved with colorectal cancer aggressive capacity and that diagnostic evaluation of PTEN expression may provide valuable prognostic information to aid treatment strategies for colorectal cancer patients.
A novel insertion mutation in the cartilage-derived morphogenetic protein-1 (CDMP1) gene underlies Grebe-type chondrodysplasia in a consanguineous Pakistani family
Authors: Basit Sulman , Naqvi Syed Kamran-ul-Hassan , Wasif Naveed , Ali Ghazanfar , Ansar Muhammad , Ahmad Wasim 
Published: November 2008

Abstract

Background
Grebe-type chondrodysplasia (GCD) is a rare autosomal recessive syndrome characterized by severe acromesomelic limb shortness with non-functional knob like fingers resembling toes. Mutations in the cartilage-derived morphogenetic protein 1 (CDMP1) gene cause Grebe-type chondrodysplasia.

Methods
Genotyping of six members of a Pakistani family with Grebe-type chondrodysplasia, including two affected and four unaffected individuals, was carried out by using polymorphic microsatellite markers, which are closely linked to CDMP1 locus on chromosome 20q11.22. To screen for a mutation in CDMP1 gene, all of its coding exons and splice junction sites were PCR amplified from genomic DNA of affected and unaffected individuals of the family and sequenced directly in an ABI Prism 310 automated DNA sequencer.

Results
Genotyping results showed linkage of the family to CDMP1 locus. Sequence analysis of the CDMP1 gene identified a novel four bases insertion mutation (1114insGAGT) in exon 2 of the gene causing frameshift and premature termination of the polypeptide.

Conclusion
We describe a 4 bp novel insertion mutation in CDMP1 gene in a Pakistani family with Grebe-type chondrodysplasia. Our findings extend the body of evidence that supports the importance of CDMP1 in the development of limbs.
STUDIES IN THE CLARIFICATION OF MILK
Authors: Marshall Charles E. 
Published: November 2008

These studies were started during the summer of 1914 and have been continued in varying degrees since that time. They were made possible by the De Laval Separator Company of New York City, which established a fund placed in the hands of the Treasurer of the College to meet the expenses incurred. The firm was desirous of knowing the truth about clarification, so far as it can be determined; accordingly, the work was placed on the usual basis of Experiment Station investigational undertakings with the enjoyment of complete independence. The firm has been a constant source of helpfulness and at no time has it attempted or interfered to influence results or the free publication of the findings. I make this statement as a due appreciation of the helpfulness, generosity and sympathetic attitude of a commercial firm. If any commercial motive exists, it can be only a desire to have facts and truth as a basis for their procedure and progress in manufacture.
Analysis of scaling methods in deriving future volume evolutions of valley glaciers
Authors: Radić Valentina , Hock Regine , Oerlemans Johannes 
Published: November 2008

AbstractVolume–area scaling is a common tool for deriving future volume evolutions of valley glaciers and their contribution to sea-level rise. We analyze the performance of scaling relationships for deriving volume projections in comparison to projections from a one-dimensional ice-flow model. The model is calibrated for six glaciers (Nigardsbreen, Rhonegletscher, South Cascade Glacier, Sofiyskiy glacier, midre Lovénbreen and Abramov glacier). Volume evolutions forced by different hypothetical mass-balance perturbations are compared with those obtained from volume–area (V-A), volume–length (V-L) and volume–area–length (V-A-L) scaling. Results show that the scaling methods mostly underestimate the volume losses predicted by the ice-flow model, up to 47% for V-A scaling and up to 18% for V-L scaling by the end of the 100 year simulation period. In general, V-L scaling produces closer simulations of volume evolutions derived from the ice-flow model, suggesting that V-L scaling may be a better approach for deriving volume projections than V-A scaling. Sensitivity experiments show that the initial volumes and volume evolutions are highly sensitive to the choice of the scaling constants, yielding both over- and underestimates. However, when normalized by initial volume, volume evolutions are relatively insensitive to the choice of scaling constants, especially in the V-L scaling. The 100 year volume projections differ within 10% of initial volume when the V-A scaling exponent commonly assumed, γ = 1.375, is varied by −30% to +45% (γ = [0.95, 2.00]) and the V-L scaling exponent, q = 2.2, is varied by −30% to +45% (q = [1.52, 3.20]). This is encouraging for the use of scaling methods in glacier volume projections, particularly since scaling exponents may vary between glaciers and the scaling constants are generally unknown.
Inference of velocity pattern from isochronous layers in firn, using an inverse method
Authors: Eisen Olaf 
Published: November 2008

AbstractThe suitability of a kinematic approach for finding the velocity field from dated internal-layer architecture in firn is investigated. Internal layers are isochrones and the depositional age of a layer particle is treated as a tracer. The forward problem uses two-dimensional steady-state advection of age and conservation of mass to predict layer architecture. Different combinations of constraints on horizontal and vertical velocity properties are added. The inverse problem can be formulated as the solution of underdetermined and overdetermined systems of equations. The systems are solved using singular-value decomposition, allowing analysis of the singular-value spectrum, model resolution and data resolution. Solutions of the inverse problem are evaluated by comparing the velocity-field solutions with synthetic input velocity data. Unlike conventional accumulation estimates, the new approach takes lateral advection into account, enabling improved separation of spatial and temporal variations in accumulation. Two glaciological applications are presented: the determination of the migration velocity of a spatially non-stationary accumulation pattern and reconstruction of past accumulation and its stationarity over time.
Calving and ice-shelf break-up processes investigated by proxy: Antarctic tabular iceberg evolution during northward drift
Authors: Scambos T. , Ross R. , Bauer R. , Yermolin Y. , Skvarca P. , Long D. , Bohlander J. , Haran T. 
Published: November 2008

AbstractUsing a combination of satellite sensors, field measurements and satellite-uplinked in situ observing stations, we examine the evolution of several large icebergs drifting east of the Antarctic Peninsula towards South Georgia Island. Three styles of calving are observed during drift: ‘rift calvings’, ‘edge wasting’ and ‘rapid disintegration’. Rift calvings exploit large pre-existing fractures generated in the shelf environment and can occur at any stage of drift. Edge wasting is calving of the iceberg perimeter by numerous small edge-parallel, sliver-shaped icebergs, preserving the general shape of the main iceberg as it shrinks. This process is observed only in areas north of the sea-ice edge. Rapid disintegration, where numerous small calvings occur in rapid succession, is consistently associated with indications of surface melt saturation (surface lakes, firn-pit ponding). Freeboard measurements by ICESat indicate substantial increases in ice-thinning rates north of the sea-ice edge (from <10 m a−1 to >30 m a−1), but surface densification is shown to be an important correction (>2 m freeboard loss before the firn saturates). Edge wasting of icebergs in ‘warm’ surface water (sea-ice-free, >−1.8°C) implies a mechanism based on waterline erosion. Rapid disintegration (‘Larsen B-style’ break-up) is likely due to the effects of surface or saturated-firn water acting on pre-existing crevasses, or on wave- or tidally induced fractures. Changes in microwave backscatter of iceberg firn as icebergs drift into warmer climate and experience increased surface melt suggest a means of predicting when floating ice plates are evolving towards disintegration.
In situ measurements of snow surface roughness using a laser profiler
Authors: Lacroix P. , Legrésy B. , Langley K. , Hamran S.E. , Kohler J. , Roques S. , Rémy F. , Dechambre M. 
Published: November 2008

AbstractThe snow surface roughness at centimetre and millimetre scales is an important parameter related to wind transport, snowdrifts, snowfall, snowmelt and snow grain size. Knowledge of the snow surface roughness is also of high interest for analyzing the signal from radar sensors such as SAR, altimeters and scatterometers. Unfortunately, this parameter has seldom been measured over snow surfaces. The techniques used to measure the roughness of other surfaces, such as agricultural or sand soils, are difficult to implement in polar regions because of the harsh climatic conditions. In this paper we develop a device based on a laser profiler coupled with a GPS receiver on board a snowmobile. This instrumentation was tested successfully in midre Lovénbreen, Svalbard, in April 2006. It allowed us to generate profiles of 3 km sections of the snow-covered glacier surface. Because of the motion of the snowmobile, the roughness signal is mixed with the snowmobile signal. We use a distance/frequency analysis (the empirical mode decomposition) to filter the signal. This method allows us to recover the snow surface structures of wavelengths between 4 and 50 cm with amplitudes of >1 mm. Finally, the roughness parameters of snow surfaces are retrieved. The snow surface roughness is found to be dependent on the scales of the observations. The retrieved RMS of the height distribution is found to vary between 0.5 and 9.2 mm, and the correlation length is found to be between 0.6 and 46 cm. This range of measurements is particularly well adapted to the analysis of GHz radar response on snow surfaces.
Modeling dynamic controls on ice streams: a Bayesian statistical approach
Authors: Berliner L.M. , Jezek K. , Cressie N. , Kim Y. , Lam C.Q. , Van Der Veen C.J. 
Published: November 2008

AbstractOur main goal is to exemplify the study of ice-stream dynamics via Bayesian statistical analysis incorporating physical, though imperfectly known, models using data that are both incomplete and noisy. The physical–statistical models we propose account for these uncertainties in a coherent, hierarchical manner. The initial modeling assumption estimates basal shear stress as equal to driving stress, but subsequently includes a random corrector process to account for model error. The resulting stochastic equation is incorporated into a simple model for surface velocities. Use of Bayes’ theorem allows us to make inferences on all unknowns given basal elevation, surface elevation and surface velocity. The result is a posterior distribution of possible values that can be summarized in a number of ways. For example, the posterior mean of the stress field indicates average behavior at any location in the field, and the posterior standard deviations describe associated uncertainties. We analyze data from the ‘Northeast Greenland Ice Stream’ and illustrate how scientific conclusions may be drawn from our Bayesian analysis.
Preparation and characterization of polyaniline with high electrical conductivity
Authors: Zhang Keqing , Jing Xinli 
Published: November 2008

AbstractIn the present paper, polyaniline (PANI) was polymerized by ammonium persulphate using a chemically oxidative process under mild tempertures ranging from −5–20°C. Electrical conductivity of as synthesized PANI got enhanced gradually owing to the increase in molecular weight and crystallinity with decrease in synthesis temperature. Extraction with tetrahydrofuran (THF) was employed as the purification method of emeraldine base (EB) to enhance the electrical conductivity of PANI effectively attributed to the removal of the low molecular weight fractions and defective molecular chains. Methanesulfonic acid (MSA) was used to dope EB due to its strong acidity and small molecular size, and the amount of dopant versus EB was also optimized. Using a novel “synergistic doping” process with m‐cresol, electrical conductivity of PANI is further enhanced owing to more regular molecular chains which resulted in better interchain charge carriers' conduction. The emeraldine salts obtained finally have high electrical conductivity reaching up to 32.5 S cm−1, which is much higher than that of the conventionally synthesized sample reported previously. Copyright © 2008 John Wiley & Sons, Ltd.
mTORC2 is the hydrophobic motif kinase for SGK1
Authors: Yan Lijun , Mieulet Virginie , Lamb Richard F. 
Published: November 2008

The activation of the AGC (protein kinase A/protein kinase G/protein kinase C)-family kinase SGK1 (serum- and glucocorticoid-induced kinase 1) by insulin via PI3K (phosphoinositide 3-kinase) signalling has been appreciated for almost 10 years. PDK1 (phosphoinositide-dependent protein kinase 1), a kinase that phosphorylates the SGK1 catalytic domain at Thr256, is known to play a critical role in SGK1 activation. However, the identity of the protein kinase(s) responsible for phosphorylation of Ser422, a site outside the catalytic domain (the so-called hydrophobic motif, or HM) that promotes activation of the kinase by PDK1, was unclear. In work reported in this issue of the Biochemical Journal, García-Martínez and Alessi have revealed the identity of a ‘PDK2’ kinase that catalyses Ser422 phosphorylation as mTORC2 (mammalian target of rapamycin complex 2), a multiprotein kinase that phosphorylates a similar site in PKB (protein kinase B).
Implications for Asset Pricing Puzzles of a Roll‐over Assumption for the Risk‐Free Asset*
Authors: WARREN GEOFFREY J. 
Published: November 2008

ABSTRACTThe equity risk premium and risk‐free rate puzzles are largely resolved by combining persistent uncertainty over the long‐term consumption growth rate with analysis of the risk‐free asset on a ‘roll‐over’ basis. Under these conditions, cash equivalents are evaluated as a multi‐period investment strategy that hedges against adverse growth rate outcomes. The premium on the risky asset is raised and the risk‐free rate lowered due to their respective relation with multi‐period consumption risk. Historical average asset returns are matched at plausible risk aversion.
Molecular Characterization of Two Silenced y‐type Genes for Glu‐B1 in Triticum aestivum ssp. yunnanese and ssp. tibetanum
Authors: Yuan Zhong‐Wei , Chen Qi‐Jiao , Zhang Lian‐Quan , Yan Ze‐Hong , Zheng You‐Liang , Liu Deng‐Cai 
Published: November 2008

Abstract The high molecular weight glutenin subunits (HMW‐GSs) are a major class of common wheat storage proteins. The bread‐making quality of common wheat flour is influenced by the composition of HMW‐GSs. In the present study, two unexpressed 1By genes from Triticum aesitvum L.ssp.yunnanese AS332 and T. aesitvum ssp.tibetanum AS908 were respectively cloned and characterized. The results indicated that both of the silenced 1By genes in AS332 and AS908 were 1By9. In contrast to previously reported mechanisms for silenced genes 1Ax and 1Ay, which was due to the insertion of transposon elements or the presence of premature stop codon via base substitution of C→T transition in trinucleotides CAA or CAG, the silence of 1By9 genes was caused by premature stop codons via the deletion of base A in trinucleotide CAA, which lead to frameshift mutation and indirectly produced several premature stop codons (TAG) downstream of the coding sequence.