bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serial concatenation of Hermitian codes with ring‐TCM codes
Authors: Johnston Martin , Carrasco Rolando A. 
Published: September 2007

AbstractHermitian codes are a class of very long algebraic‐geometric (AG) codes constructed from Hermitian curves, which outperform Reed–Solomon codes defined over the same finite fields and with the same code rates, as recently demonstrated by the authors. However, since there are no soft‐decision decoding algorithms for AG codes in the literature, the performance of Hermitian codes is limited and their potential is yet to be realized. An alternative method for achieving more significant coding gains is presented in this paper by serially concatenating long Hermitian codes with ring‐trellis‐coded modulation codes over the ring of integers ℤ4 and evaluating their performance through simulation results on the AWGN and Rayleigh fading channels. The scheme achieves large coding gains over single Hermitian and Reed–Solomon codes with no increase in bandwidth use and a performance comparable with the well‐known capacity‐approaching codes. Copyright © 2007 John Wiley & Sons, Ltd.
Historical review of sample preparation for chromatographic bioanalysis: pros and cons
Authors: Chang Min S. , Ji Qin , Zhang Jun , El‐Shourbagy Tawakol A. 
Published: September 2007

AbstractSample preparation is a major task in a regulated bioanalytical laboratory. The sample preparation procedure significantly impacts assay throughput, data quality, analysis cost, and employee satisfaction. Therefore, selecting and optimizing an appropriate sample preparation method is essential for successful method development. Because of our recent expertise, this article is focused on sample preparation for high‐performance liquid chromatography with mass spectrometric detection. Liquid chromatography with mass spectrometric detection (LC‐MS) is the most common detection technique for small molecules used in regulated bioanalytical laboratories. The sample preparation technologies discussed are pre‐extraction and post‐extraction sample processing, protein precipitation (PPT), liquid–liquid extraction (LLE), offline solid‐phase extraction (SPE), and online solid‐phase extraction. Since all these techniques were in use for more than two decades, numerous applications and variations exist for each technique. We will not attempt to categorize each variation. Rather, the development history, a brief theoretical background, and selected references are presented. The strengths and the limitations of each method are discussed, including the throughput improvement potential. If available, illustrations from presentations at various meetings by our laboratory are used to clarify our opinion. Drug Dev Res 68:107–133, 2007. ©2007 Wiley‐Liss, Inc.
Methylphenidate treatment recovers stress‐induced elevated dendritic spine densities in the rodent dorsal anterior cingulate cortex
Authors: Zehle Stefanie , Bock Joerg , Jezierski Grzegorz , Gruss Michael , Braun Katharina 
Published: September 2007

AbstractExposing pups of the rodent species Octodon degus to periodic separation stress during the first three postnatal weeks leads to behavioral alterations, which include reduced attention towards an emotional stimulus and motoric hyperactivity. These behavioral changes, which are reminiscent of symptoms of attention deficit hyperactivity disorder (ADHD), are paralleled by synaptic changes in the dorsal anterior cingulate cortex (ACd), a limbic cortex region, which plays a key role in the modulation of attentional and executive functions. ADHD is typically treated with methylphenidate (MP), a drug acting on the dopaminergic system. However, the effect of chronic MP‐treatment on neuronal and synaptic maturation in the developing brain is unknown. Applying the Golgi‐Cox stainining technique, we tested in which way chronic MP‐treatment interferes with dendritic and synaptic development in the ACd and whether this treatment can restore the stress‐induced changes of neuronal connectivity. We found that chronic treatment with 1 mg/kg MP recovers stress‐induced changes of spine densities in the ACd. Furthermore, MP‐treatment resulted in increased dendritic length and complexity in both, stressed as well as unstressed control animals. These results indicate that synaptic reorganization as well as dendritic growth in the prefrontal cortex continue into prepuberty and are modulated by MP‐treatment. © 2007 Wiley Periodicals, Inc. Develop Neurobiol, 2007
Extrinsic regulation of T‐type Ca2+ channel expression in chick nodose ganglion neurons
Authors: Pachuau Judith , Martin‐Caraballo Miguel 
Published: September 2007

AbstractFunctional expression of T‐type Ca2+ channels is developmentally regulated in chick nodose neurons. In this study we have tested the hypothesis that extrinsic factors regulate the expression of T‐type Ca2+ channels in vitro. Voltage‐gated Ca2+ currents were measured using whole‐cell patch clamp recordings in E7 nodose neurons cultured under various conditions. Culture of E7 nodose neurons for 48 h with a heart extract induced the expression of T‐type Ca2+ channels without any significant effect on HVA currents. T‐type Ca2+ channel expression was not stimulated by survival promoting factors such as BDNF. The stimulatory effect of heart extract was mediated by a heat‐labile, trypsin‐sensitive factor. Various hematopoietic cytokines including CNTF and LIF mimic the stimulatory effect of heart extract on T‐type Ca2+ channel expression. The stimulatory effect of heart extract and CNTF requires at least 12 h continuous exposure to reach maximal expression and is not altered by culture of nodose neurons with the protein synthesis inhibitor anisomycin, suggesting that T‐type Ca2+ channel expression is regulated by a posttranslational mechanism. Disruption of the Golgi apparatus with brefeldin‐A inhibits the stimulatory effect of heart extract and CNTF suggesting that protein trafficking regulates the functional expression of T‐type Ca2+ channels. Heart extract‐ or CNTF‐evoked stimulation of T‐type Ca2+ channel expression is blocked by the Jak/STAT and MAP kinase blockers, AG490 and U0126, respectively. This study provides new insights into the electrical differentiation of placode‐derived sensory neurons and the role of extrinsic factors in regulating the functional expression of Ca2+ channels. © 2007 Wiley Periodicals, Inc. Develop Neurobiol, 2007
Nitric oxide release from a single cell affects filopodial motility on growth cones of neighboring neurons
Authors: Tornieri Karine , Rehder Vincent 
Published: September 2007

AbstractNitric oxide (NO), a gaseous messenger, has been reported to be involved in a variety of functions in the nervous system, ranging from neuronal pathfinding to learning and memory. We have shown previously that the application of NO via NO donors to growth cones of identified Helisoma buccal neurons B5 in vitro induces an increase in filopodial length, a decrease in filopodial number, and a slowing in neurite advance. It is unclear, however, whether NO released from a physiological source would affect growth cone dynamics. Here we used cell bodies of identified neurons known to express the NO synthesizing enzyme nitric oxide synthase (NOS) as a source of constitutive NO production and tested their effect on growth cones of other cells in a sender‐receiver paradigm. We showed that B5 cell bodies induced a rapid increase in filopodial length in NO‐responsive growth cones, and that this effect was blocked by the NOS inhibitor 7‐NI, suggesting that the effect was mediated by NO. Inhibition of soluble guanylyl cyclase (sGC) with ODQ blocked filopodial elongation induced by B5 somata, confirming that NO acted via sGC. We also demonstrate that the effect of NO was reversible and that a cell releasing NO can affect growth cones over a distance of at least 100 μm. Our results suggest that NO released from a physiological source can affect the motility of nearby growth cones and thus should be considered a signaling molecule with the potential to affect the outcome of neuronal pathfinding in vivo. © 2007 Wiley Periodicals, Inc. Develop Neurobiol, 2007
Transcription factor TEAD2 is involved in neural tube closure
Authors: Kaneko Kotaro J. , Kohn Matthew J. , Liu Chengyu , DePamphilis Melvin L. 
Published: September 2007

AbstractTEAD2, one of the first transcription factors expressed at the beginning of mammalian development, appears to be required during neural development. For example, Tead2 expression is greatest in the dorsal neural crest where it appears to regulate expression of Pax3, a gene essential for brain development. Consistent with this hypothesis, we found that inactivation of the Tead2 gene in mice significantly increased the risk of exencephaly (a defect in neural tube closure). However, none of the embryos exhibited spina bifida, the major phenotype of Pax3 nullizygous embryos, and expression of Pax3 in E11.5 Tead2 nullizygous embryos was normal. Thus, Tead2 plays a role in neural tube closure that is independent of its putative role in Pax3 regulation. In addition, the risk of exencephaly was greatest with Tead2 nullizygous females, and could be suppressed either by folic acid or pifithrin‐α. These results reveal a maternal genetic contribution to neural tube closure, and suggest that Tead2‐deficient mice provide a model for anencephaly, a common human birth defect that can be prevented by folic acid. genesis 45:577–587, 2007. Published 2007 Wiley‐Liss, Inc.
Visual deficits in developmental dyslexia: relationships between non‐linguistic visual tasks and their contribution to components of reading
Authors: Jones Manon W. , Branigan Holly P. , Kelly M. Louise 
Published: September 2007

AbstractDevelopmental dyslexia is often characterized by a visual deficit, but the nature of this impairment and how it relates to reading ability is disputed (Brain 2003; 126: 841–865). In order to investigate this issue, we compared groups of adults with and without dyslexia on the Ternus, visual‐search and symbols tasks. Dyslexic readers yielded more errors on the visual‐search and symbols tasks compared with non‐dyslexic readers. A positive correlation between visual‐search and symbols task performance suggests a common mechanism shared by these tasks. Performance on the visual‐search and symbols tasks also correlated with non‐word reading and rapid automatized naming measures, and visual search contributed independent variance to non‐word reading. The Ternus task did not discriminate reading groups nor contributed significant variance to reading measures. We consider how visual‐attention processes might underlie specific component reading measures. Copyright © 2007 John Wiley & Sons, Ltd.
Association between broadly defined bulimia nervosa and drug use disorders: Common genetic and environmental influences
Authors: Baker Jessica H. , Mazzeo Suzanne E. , Kendler Kenneth S. 
Published: September 2007

AbstractObjective:Previous research has shown an association between bulimia (BN) and drug use disorders (DUD). The purpose of the present study was to investigate possible influences on the comorbidity between BN and DUD.Method:Participants included 490 monozygotic and 354 dizygotic female twins and 930 females from opposite sex pairs. Multiple logistic regression analyses were used to test shared correlates and mediators. Bivariate twin analyses were used to investigate the contribution of genes and environment to the correlation between BN and DUD.Results:Depression, neuroticism, and childhood sexual abuse (CSA) mediated the association between BN and DUD regardless of which disorder was used as the dependent variable. Analyses also indicated genetic and nonshared environmental overlap between BN and DUD.Conclusion:The association between BN and DUD is due mostly to overlapping genetic influences with a smaller contribution from nonshared environment. Depression, neuroticism, and CSA are likely important shared correlates. © 2007 by Wiley Periodicals, Inc. Int J Eat Disord 2007
IL‐35 is a novel cytokine with therapeutic effects against collagen‐induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells
Authors: Niedbala Wanda , Wei Xiao‐qing , Cai Beilei , Hueber Axel J , Leung Bernard P. , McInnes Iain B. , Liew Foo Y. 
Published: September 2007

AbstractEpstein‐Barr virus‐induced gene 3 (EBI3) and the p35 subunit of IL‐12 have been reported to form a heterodimeric hematopoietin in human and mouse. We have constructed a heterodimeric protein covalently linking EBI3 and p35, to form a novel cytokine which we now call IL‐35. The Fc fusion protein of IL‐35 induced proliferation of murine CD4+CD25+ and CD4+CD25– T cells when stimulated with immobilized anti‐CD3 and anti‐CD28 antibodies in vitro. The IL‐35‐expanded CD4+CD25+ T cell population expressed Foxp3 and produced elevated levels of IL‐10, whereas the IL‐35‐induced CD4+CD25– T cells produced IFN‐γ but not IL‐4. The in vitro expanded CD4+CD25+ T cells retained their suppressive functions against CD4+CD25– effector cells. Furthermore, when cultured with soluble anti‐CD3 antibody and antigen‐presenting cells, IL‐35 suppressed the proliferation of CD4+CD25– effector cells. Moreover, IL‐35 inhibited the differentiation of Th17 cells in vitro. In vivo, IL‐35 effectively attenuated established collagen‐induced arthritis in mice, with concomitant suppression of IL‐17 production but enhanced IFN‐γ synthesis. Thus, IL‐35 is a novel anti‐inflammatory cytokine suppressing the immune response through the expansion of regulatory T cells and suppression of Th17 cell development.
Template‐Controlled Reactivity in the Organic Solid State by Principles of Coordination‐Driven Self‐Assembly
Authors: Bučar Dejan‐Krešimir , Papaefstathiou Giannis S. , Hamilton Tamara D. , Chu Qianli L. , Georgiev Ivan G. , MacGillivray Leonard R. 
Published: September 2007

AbstractIn this microreview, we show how principles of coordination‐driven self‐assembly can be used to direct chemical reactivity in the organic solid state. We also show how products obtained from the templated solid‐state reactions can be used as organic building units of metal–organic frameworks and coordination capsules. Self‐assembled structures based on dinuclear ZnII and AgI complexes are used to direct stereocontrolled [2+2] photodimerizations of vinylpyridines in the solid state in up to quantitative yield. The products are used as bi‐ and polytopic ligands of self‐assembled coordination capsules and metal–organic frameworks. We also describe emerging metal‐based approaches to conduct mechanochemical reactions in organic solids. In addition to the field of supramolecular coordination chemistry, these observations impact the field of green chemistry.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
(2,2‐Dibromovinyl)ferrocene as a Building Block for the Assembly of Heterodinuclear Complexes – Preparation of an σ‐Alkenylpalladium Complex and Dimetallic Dithioether Complexes
Authors: Clément Sébastien , Guyard Laurent , Knorr Michael , Villafañe Fernando , Strohmann Carsten , Kubicki Marek M. 
Published: September 2007

AbstractThe oxidative addition of (2,2‐dibromovinyl)ferrocene [Br2C=C(H)–Fc] (1) to [Pd(PPh3)4] yields the heterodinuclear σ‐alkenyl complex trans‐[{Pd(Br)(PPh3)2}–C(Br)=C(H)–Fc] (2). Nucleophilic attack of sodium thiolates on 1 unexpectedly affords the vinyl thioether derivatives (Z)‐[(RS)(H)C=C(H)–Fc] (4a: R = Ph; 4b: R = tBu; 4c: R = Et). Complexes 4a and 4c can also be prepared by addition of NaSR across the triple bond of Fc–C≡C–H (3). Addition of an excess of NaSR to 1 affords the dithioether derivatives (Z)‐[(RS)(H)C=C(SR)–Fc] (5a: R = Ph; 5b: R = p‐tolyl; 5c: R = Et). An addition/elimination sequence is suggested to account for this surprising result. The yield of 5c is very low due to a competing formation of ethynylferrocene (3). Reaction of 5b with [Re(thf)(CO)3(μ‐Br)]2 and [PtCl2(PhCN)2] leads to the heterodinuclear chelate complexes [Fc{C(S–p‐tolyl)=C(H)(S–p‐tolyl)}Re(Br)(CO)3] (6) and [Fc{C(S–p‐tolyl)=C(H)(S–p‐tolyl)}PtCl2] (7a), respectively. Metathesis of the fluxional compound 7a in the presence of NaI affords [Fc{C(S–p‐tolyl)=C(H)(S–p‐tolyl)}PtI2] (7b). The electrochemical properties of some of these complexes have been studied by means of cyclic voltammetry, and the molecular structures of 1, 2, 3, 4b, 4c and 6 have been determined by X‐ray diffraction. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
[1,2,5]Selenadiazolo[3,4‐c][1,2,5]thiadiazole and [1,2,5]Selenadiazolo[3,4‐c][1,2,5]thiadiazolidyl – A Synthetic, Structural, and Theoretical Study
Authors: Bagryanskaya Irina Yu. , Gatilov Yuri V. , Gritsan Nina P. , Ikorskii Vladimir N. , Irtegova Irina G. , Lonchakov Anton V. , Lork Enno , Mews Ruediger , Ovcharenko Victor I. , Semenov Nikolay A. , Vasilieva Nadezhda V. , Zibarev Andrey V. 
Published: September 2007

AbstractA new heterocyclic system, namely [1,2,5]selenadiazolo[3,4‐c][1,2,5]thiadiazole (1), has been prepared in 60 % yield by the 1:1 condensation of 3,4‐diamino‐1,2,5‐thiadiazole (4) with SeCl4 in the presence of pyridine. The structures of 1 and its 1:1 complex with pyridinium chloride (5) have been elucidated by X‐ray diffraction (XRD). The reversible electrochemical reduction of 1, as well as its chemical reduction with PhS– anion, provide the long‐lived [1,2,5]selenadiazolo[3,4‐c][1,2,5]thiadiazolidyl radical anion (2), which has been isolated in the form of the thermally stable salt [K(18‐crown‐6)][2] (3) in 75 % yield. The experimental structural and spectral characteristics of 1 and 2 agree fairly well with those obtained from density functional (DFT) calculations. The salt 3 has been characterized by ESR spectroscopy (in the solid state and in solution) and XRD. The radical anion 2 acts as a bridging ligand in crystalline 3. Magnetic measurements on salt 3 reveal weak antiferromagnetic interactions (J = –1.65 cm–1). The magnetic structures of 3 and its disulfur congener 11 have been analyzed in terms of dimeric exchange integrals calculated by spin‐unrestricted broken‐symmetry DFT and post‐HF methods.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
Structure and Photochemical Isomerization of the Dinuclear Gold(I) Halide Bis(diphenylphosphanyl)ethylene Complexes: Correlation Between Quantum Yield and Aurophilicity
Authors: Foley Janet B. , Gay Stanley E. , Vela Michael J. , Foxman Bruce M. , Bruce Alice E. , Bruce Mitchell R. M. 
Published: September 2007

AbstractThe crystal structures for cis‐(Ph2PCH=CHPPh2)(AuI)2 and trans‐(Ph2PCH=CHPPh2)(AuI)2 are reported. The structure of cis‐(Ph2PCH=CHPPh2)(AuI)2 reveals a short intramolecular Au–Au distance of 2.9526(5) Å, while the structure of trans‐(Ph2PCH=CHPPh2)(AuI)2 shows intermolecular Au–Au distances of 3.2292(7) Å. Structural data for the iodide complexes are compared to previously reported crystal structural data for cis‐ and trans‐(Ph2PCH=CHPPh2)(AuCl)2 and dppbz(AuCl)2. The quantum yields for the photochemical isomerization of cis‐(Ph2PCH=CHPPh2)(AuX)2 with 334‐nm light, Φ(cis → trans), are 0.204, 0.269, and 0.363 for X = Cl, Br, and I, respectively. Prior results from ab initio calculations on the model cis‐ and trans‐Au2X2C2H2(PH2)2 complexes aid in the interpretation of the correlation between the quantum yield for isomerization and the calculated aurophilic attraction potential V(Re). (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
Efficient, Ultrafast, Microwave‐Assisted Syntheses of Cycloplatinated Complexes
Authors: Godbert Nicolas , Pugliese Teresa , Aiello Iolinda , Bellusci Anna , Crispini Alessandra , Ghedini Mauro 
Published: September 2007

AbstractCyclometallated chloridoplatinum complexes containing neutral monodentate ligands such as 2‐phenylpyridine (1a), 2‐(2′‐thienyl)pyridine (1c) or 4‐methoxypyridine (1d), as well as the cyclometallated benzo[h]quinoline chlorido complex with 4‐methoxypyridine (2d), can be synthesised in a few minutes by irradiating the reaction mixture with microwaves. The single‐crystal X‐ray molecular structures of the solvato complexes 1·dmso and 2·dmso as well as 1c, 1d and 2d are reported. The availability of this class of complexes in a few minutes offers the possibility of a combinatorial approach for the preparation of libraries of homologous compounds of potential interest for applicative purposes. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
Photochemical Generation and Reactivity of Naphthyl Cations: cine Substitution
Authors: Slegt Micha , Minne Floor , Zuilhof Han , Overkleeft Hermen S. , Lodder Gerrit 
Published: September 2007

AbstractThe photochemical solvolyses of naphthalen‐1‐yl(phenyl)iodonium tetrafluoroborate and naphthalen‐2‐yl(phenyl)iodonium tetrafluoroborate in methanol regiospecifically yield the naphthalen‐1‐ and ‐2‐yl ethers but afford scrambled 1‐ and 2‐phenylnaphthalene Friedel–Crafts products. It is demonstrated that singlet naphthyl cations account for the formation of the naphthyl ethers, but that the cine substitution is most likely to be due to the intermediacy of triplet naphthyl cations. According to the experiments reported here, the singlet naphthyl cations are lower in energy than their triplet isomers. High‐level MO calculations for the cations in methanol support this finding. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
An Expeditious Assembly of 3,4‐Benzannulated 8‐Oxabicyclo[3.2.1]octane Systems by [2+2+2] Alkyne Cyclotrimerisation: Total Synthesis of (–)‐Bruguierol A
Authors: Ramana Chepuri V. , Salian Sumanth R. , Gonnade Rajesh G. 
Published: September 2007

AbstractFacile construction of benzene‐fused 8‐oxabicyclo[3.2.1]octane systems by employing a cross alkyne cyclotrimerisation reaction was explored. With this procedure, (–)‐bruguierol A was synthesised, and its absolute configuration was established. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
Hydrophobically Directed Aldol Reactions: Polystyrene‐Supported L‐Proline as a Recyclable Catalyst for Direct Asymmetric Aldol Reactions in the Presence of Water (Eur. J. Org. Chem. 28/2007)
Authors: Gruttadauria Michelangelo , Giacalone Francesco , Mossuto Marculescu Adriana , Lo Meo Paolo , Riela Serena , Noto Renato 
Published: September 2007

AbstractThe cover picture shows the aldol reaction between ketones and arylaldehydes carried out by using a polystyrene‐supported L‐proline catalyst. This material furnishes aldol products in high yields and stereoselectivities. Screening of solvents showed that these reactions take place only in the presence of water. This solvent effect, coupled with the high stereoselectivities observed, has been explained by the formation of a hydrophobic core in the inner surface of the resin with the hydrophilic proline moiety in the resin/water interface. Such a microenvironment promotes the aldol reaction and increases the stereoselectivity. Recycling investigations have shown that this material can be reused, without loss in conversion and stereoselectivity for, at least, five cycles. This catalyst can be considered a better mimic of natural Class I aldolase enzymes that use an enamine‐mediated mechanism in water. Details are discussed in the article by M. Gruttadauria et al. on p. 4688 ff. This work is dedicated to Professor Domenico Spinelli on the occasion of his 75th birthday.
Computer simulation of different modes of ACE based on the dynamic complexation model
Authors: Fang Ning , Sun Ying , Zheng Jingyan , Chen David D. Y. 
Published: September 2007

AbstractSeveral modes of the often used ACE processes are simulated based on the principle of dynamic complexation of interacting species in a capillary column. The model is built on the mass transfer equation, to provide insight into the detailed analyte migration and interaction processes in CE. Normal ACE, Hummel–Dreyer method, vacancy affinity CE, vacancy peak method, and CE frontal analysis are simulated based on typical ACE conditions, and the results are compared with the detector responses of real CE processes using BSA and warfarin as a model system. Remarkable resemblance between the simulated results and the experimental observations was demonstrated for well‐buffered ACE systems.