bluuebunny/crossref_metadata_2025_split huggingface dataset:
Carcinoma arising in fibroadenoma: Case report and review of the world literature
Authors: Yoshida Yoshiyuki , Takaoka Mitsuka , Fukumoto Manabu 
Published: February 2007

AbstractTo date 119 cases of “carcinoma arising in a fibroadenoma” have been reported in the world literature. A total of 120 cases, including the case described here, are analyzed. The mean age of the affected females was 43 years. A few patients complained of several disorders other than breast tumor before and during the development of the tumor. The tumor was most frequently located in the upper outer quadrant of the breast. Most carcinomas in fibroadenomas were lobular carcinoma in situ followed by duct carcinoma in situ. There was only one squamous cell carcinoma. The malignant process was confined to the fibroadenoma in over half of the cases. In some cases additional foci outside the fibroadenoma were reported. Radical mastectomy was the most frequent treatment. The prognosis was usually good.
Treatment of perineural metastasis from squamous carcinoma of the skin with aggressive combination chemotherapy and irradiation
Authors: Loeffler Jay S. , Larson David A. , Clark John R. , Weichselbaum Ralph R. , Norris Charles M. , Ervin Thomas J. 
Published: February 2007

AbstractPerineural metastasis from squamous cell carcinoma is quite rare. The treatment of such metastasis in the head and neck region is difficult due to base of skull or intracranial involvement by tumor. Surgery and radiotherapy may provide local control, but patients often fail distantly. We present a patient with squamous cell carcinoma presenting with perineural metastasis who was successfully treated with combination chemotherapy and definitive radiation therapy. Suggestions of therapeutic management are made of this uncommon clinical problem.
Evidence for a hepatic‐renal antagonism in the production of hepatic erythropoietin in a phenylhydrazine‐induced compensated hemolytic state in the rat
Authors: Dornfest Burton S. , Naughton Brian A. , Lapin David M. , Gordon Albert S. 
Published: February 2007

AbstractA compensated hemolytic state was induced in rats by injection of phenyl‐hydrazine (PHZ) over a 6‐week period. The liver and kidney were perfused to determine the levels and time of appearance of a hepatic erythropoietic factor (HEF) which induces the production of hepatic erythropoietin (Ep) and its antagonist, a renal inhibitory factor (RIF). Erythropoietin assays on the perfusates have been previously reported. The amount of HEF in perfusates recovered from the livers of the PHZ‐treated rats was significantly higher during the 4th to 5th weeks of treatment, coinciding with the time of increased liver production of Ep. During the 6th week of PHZ treatment, the titer of RIF in perfusates recovered from the kidney was markedly increased and the HEF titer was decreased to near the control level, suggesting an inhibitory action of RIF on HEF synthesis and/or effect. These findings indicate that an HEF/RIF control mechanism regulates hepatic Ep production in this compensated hemolytic condition.
Early onset of tetany following thyroidectomy: Report of two cases
Authors: Scanlon Edward F. , Sener Stephen F. , Murphy E. Dennis 
Published: February 2007

AbstractThe most common complication of total thyroidectomy is hypocalcemia. Following thyroidectomy, especially total thyroidectomy, the serum calcium usually falls gradually and patients do not usually require supplementary medication before 24 hours. Two cases of total thyroidectomy are presented in which the preoperative serum calcium levels were normal and hypocalcemic tetany developed in the recovery room immediately after the operation. The hypocalcemia was a temporary phenomenon, and neither patient requires supplementary calcium at the present time. There is no good explanation for this precipitous drop in the serum calcium levels in these two patients.
Carcinosarcoma of the gallbladder: Report of a case
Authors: Lopez Gloria E. , Strimel William , Herrera‐Ornelas Lemuel 
Published: February 2007

AbstractCarcinosarcomas of the gallbladder are rare tumors characterized by malignant epithelial and mesenchymal components that grow intermingled into each other. Herein we present a case that illustrates the difficulties in the diagnosis and the clinical management of this entity.
The selected use of ultrasound mammography to improve diagnostic accuracy in carcinoma of the breast
Authors: Frazier Thomas G. , Murphy J. Thomas , Furlong Ayn 
Published: February 2007

AbstractOur initial experience with diagnostic ultrasound mammography (UM) showed it to be of high diagnostic accuracy and improved specificity when compared with x‐ray mammography (XRM) in certain categories of patients. To evaluate this modality further, we reviewed our experience with 600 consecutive patients who underwent ultrasound mammography as part of their initial evaluation for breast disease. Five categories of patients were reviewed: I: age 35 or less—129; II: DY or P‐2 pattern on XRM—174; III: negative XRM but symptoms requiring additional evaluation—81; IV: high risk remaining breast in patients previously having mastectomy—48; V: refusal of repeat XRM because of pregnancy, lactation, or fear of radiation exposure—168.Fifty‐five solid lesions were diagnosed, including 36 carcinomas. Seventeen of these were not diagnosed on x‐ray mammography, giving an improved pick‐up of carcinoma in this overall group of 2.83%. Of particular interest was that, of the 27 carcinomas that were found in the group having XRM, 8 or 29.6% were missed on that modality alone. Five of these (62.5%) were patients having a DY pattern. All patients have been followed carefully and re‐examined at 3‐month intervals, with no evidence of a false negative examination. Overall, we feel diagnostic ultrasound mammography is a valuable adjunct to x‐ray mammography and recommend its continued use in selected groups of patients where it has a superior diagnostic accuracy over x‐ray mammography alone.
Paget's disease of the breast presenting as a cutaneous horn
Authors: Dabski Krzysztof , Stoll Howard L. 
Published: February 2007

AbstractA 67‐year‐old woman developed a cutaneous horn on the nipple of her right breast. Biopsy of the skin underlying the horn disclosed Paget's disease of the breast. An intraductal adenocarcinoma of the same breast was found on mastectomy. High index of suspicion is mandatory in evaluating all nipple lesions.
Biochemical and hematological tests in patients with breast carcinoma: Correlations with extent of disease, sites of relapse, and prognosis
Authors: Lee Yeu‐Tsu N. (Margaret) 
Published: February 2007

AbstractThe value of serial biochemical and hematological tests of blood in differentiating stages and in detecting recurrence of breast carcinoma was studied in 500 patients. Patients who had mastectomy and were with no evidence of disease (NED group) had higher hemoglobin, albumin, total protein, and lower LDH than patients with any amount of breast carcinoma. These four tests became more abnormal in patients with metastatic disease (group IV). In addition, peripheral lymphocyte count was significantly decreased, and SGOT, AP, alpha‐1 globulin, and CEA significantly increased, when patients developed recurrent or metastatic disease. Patients with disseminated soft tissue or lung metastasis had less abnormality of such blood tests than those with metastasis in bone or other visceras. Immunoglobulins (IgG, IgA, IgM) were not different between early or late stages, nor specific sites of metastatic involvement. Among patients with a greater amount of loco‐regional disease (group III) and patients with metastatic disease (group IV), those who had hemoglobin ⩾ 12.5 gm%, lymphocyte count of 15–2,500/cmm, albumin ⩾ 4 gm%, AP ⩽ 25 units, or LDH ⩽ 400 units had significantly better 5‐year survival rates.
Isolation of tumoricidal human factors from lymphoid cells and enzymatic digestion of these factors into small fragments retaining tumoricidal effects
Authors: Cameron Deborah J. 
Published: February 2007

AbstractGel filtration and immunoadsorption techniques have been utilized to purify tumoricidal factors from sturgeon sera as well as human plasma. Two pure proteins with cytotoxic activity were isolated from the sturgeon serum (factors A2 and B2) and two additional cytotoxic factors were isolated from human plasma (Factors A and B). In another study, human factors A and B were quantitiated in both normal donor and cancer patients' plasma. It was found that the cancer patients produced at least 50% less tumoricidal factors than did the normal donors. Furthermore, when the secretions from various lymphoid cell populations were purified utilizing immunoadsorbent techniques, it was found that the macrophages generally were producing the human tumoricidal factors. Both the sturgeon and the human factors were enzymatically cleaved into several small molecular weight fragments. Sephadex G‐75 column chromatography was then utilized to isolate the enzymatic cleavage fragments. Three fragments with cytotoxic activity were isolated from both sturgeon factor A2 and B2. Similarily, human factor A was digested into two fragments with cytotoxic activity and factor B was digested into three fragments with cytotoxic activity. The molecular weights of the cytotoxic sturgeon and human fragments ranged from 14,000 to 23,000 whereas the intact sturgeon and human factors had a molecular weight slightly greater than 67,000. Ultimately, if these small molecular weight fragments can be sequenced, then it would be possible to prepare a synthetic analog which might have future potential as a mode of treatment for cancer patients.
Malignant mesothelioma of testicular tunica
Authors: Vakalikos I. , Destouni E. , Valassis K. , Eftichiadou C. , Charalambopoulos A. , Salem N. 
Published: February 2007

AbstractA case of malignant mesothelioma of testicular tunica in a 26 year old male is presented. Operation was followed by local radiotherapy. The patient remains disease free one year after initial diagnosis.
Questionable relationship between cholecystectomy and colon cancer
Authors: Spitz Margaret R. , Russell Nancy C. , Guinee Vincent F. , Newell Guy R. 
Published: February 2007

AbstractThe relationship between prior cholecystectomy and right‐sided colon cancer was evaluated in a case‐control study. The study population comprised 267 women with right‐sided colon cancer (cases) and 268 women with left‐sided colon cancer (controls). All patients were white females, aged between 40 and 69 years, and registered at The University of Texas M.D. Anderson Hospital and Tumor Institute between 1970 and 1982. Thirty cases (11.2%) and 21 controls (7.8%) had documented prior cholecystectomy (odds ratio 1.49, 95% confidence limits 0.83, 2.67). The temporal relationship between cholecystectomy and colon cancer and the presence of diabetes were also evaluated. The authors conclude that there is no significant relationship between prior cholecystectomy and the development of right‐sided colon cancer.
Portal hypertension as an early manifestation of carcinoma of the pancreas
Authors: Lishner Michael , Jutrin Izhak , Dinbar Alex , Ravid Mordchai 
Published: February 2007

AbstractMassive hematemesis followed by 48 hours the onset of obstructive jaundice in a previously asymptomatic 38‐year‐old male patient. Splenomegaly was the only abnormal physical finding. Esophagoscopy visualized bleeding varices. The liver scan was normal. Dilated intra‐ and extrahepatic bile ducts and a possible retroperitoneal mass were demonstrated by ultrasonography. Laparotomy disclosed the presence of a carcinoma of the head and body of the pancreas that obstructed the common bile duct and the portal vein. This case report should draw attention to the vast spectrum of rare presentations of pancreas carcinoma.
Malignant melanoma appearing in a post‐mastectomy lymphedematous arm: A novel association of double primary tumors
Authors: Bartal Arie H. , Pinsky Carl M. 
Published: February 2007

AbstractThe association of a malignant melanoma appearing as an additional primary tumor in the swollen arm adjacent to a mastectomy for breast cancer is reported. A review of the literature revealed only one similar patient previously reported. In both patients, the melanoma and its metastasis were restricted to the lymphedematous arm, appeared 10 years post‐mastectomy, and responded to therapy. The similarity to Stewart‐Treves syndrome is emphasized. It is suggested that nevi developing in the lymphedematous arm post‐mastectomy should be carefully monitored and excised early whenever indicated.
Hypothesis: Increasingly intensive locoregional treatment of breast cancer may promote recurrence
Authors: Papaioannou Anaxagoras N. 
Published: February 2007

AbstractEvidence is presented compatible with the hypothesis that the inevitable tissue injury to the breast engendered by mastectomy or primary radiotherapy may in itself be a factor facilitating recurrence through a variety of local, regional, and systemic tumor‐promoting mechanisms. The potential for tumor enhancement appears to be commensurate with the extent of injury and concerns both local and systemic recurrence. The hypothesis lends itself well to experimental testing. If confirmed, it will point to the importance of minimizing any form of tissue injury in the process of treating primary breast cancer, be it by operation or irradiation and curtailing the extent or intensity of both.
Oral contraceptives and prognosis of breast cancer in women aged 35 to 50
Authors: Rosner Dutzu H. , Joy Judyann V. , Lane Warren W. 
Published: February 2007

AbstractAmong 193 breast cancer patients aged 35–50 years, there was no appreciable difference in the extent of disease at diagnosis between 53 oral contraceptive (OC) users and 140 OC non‐users. There was no overall significant difference between OC users and non‐users for either the disease‐free interval (P=.81), metastatic period (P=.41), or survival (P=.79), either alone or when adjusted for stage or family history. The survival rate of OC users of more than 2 years was similar to the survival rate of those of shorter duration ( P=.36). Patients who began the use of OC 10 years or more before diagnosis showed no statistical difference from those beginning more recently (P=.69). Recent OC users within a year of diagnosis had a survival rate similar to that of other users who stopped the pills at least 1 year prior to diagnosis (P=.14). Our data suggest no adverse effects of OC use on the prognosis of breast cancer, regardless of duration of use, latency or recency period.
Adenocarcinoma of the rete testis
Authors: Sarma Deba P. , Weilbaecher Thomas G. 
Published: February 2007

AbstractAdenocarcinoma of the rete testis is very rare. It is highly malignant with potential of early metastasis. We are reporting such a case occurring in a 34‐year‐old man who remains tumor‐free 7 years after orchiectomy. Another 20 reported cases of such a tumor from the English literature are reviewed.
Comparison of specific red‐cell adherence and immunoperoxidase staining techniques for ABO(H) blood‐group cell‐surface antigens on superficial transitional cell carcinoma of the bladder
Authors: Boileau Michel A. , Cowles Robert S. , Schmidt Karmen L. , Schmidt Waldemar A. 
Published: February 2007

AbstractThe presence or absence of blood‐group antigens have been used to predict the clinical course of patients with superficial transitional cell carcinoma of the bladder. Antigen loss has been associated with neoplastic change. The red‐cell adherence test has been the most widely accepted method of antigen determination, but this technique has inherent weaknesses. Recently, the immunoperoxidase assay has been used to detect antigens on tumor cells. We compared 30 patients using the red‐cell adherence and immunoperoxidase methods on adjacent micro to me cut sections. The red‐cell adherence and immunoperoxidase methods performed similarly (86 %) when assessing antigen presence or absence. However, the immunoperoxidase method was clearly superior in: 1) specificity for antigens on tumor cells and normal internal controls; 2) localization of antigen; 3) demonstration of cellular morphology; 4) increased objectivity of analysis; 5) ease of reproducibility; and 6) cost effectiveness.
Intramyofiber metastasis in skeletal muscle
Authors: Sarma Deba P. , Weilbaecher Thomas G. , Love Cordon L. 
Published: February 2007

AbstractMalignant epithelial cells were noted within the sarcolemmal sheath of skeletal muscle fibers in a case of recurrent laryngeal carcinoma. Literature is reviewed to evaluate the diagnostic and prognostic significance of this rare intramyofiber skeletal metastasis by cancer cells.
Radiation pneumonitis: A complication resulting from combined radiation and chemotherapy for early breast cancer
Authors: Gez E. , Sulkes A. , Isacson R. , Catane R. , Weshler Z. 
Published: February 2007

AbstractDescribed is a patient with early breast carcinoma who developed clinical radiation pneumonitis during primary radiation therapy and concomitant chemotherapy that included prednisone. This syndrome developed three days following abrupt steroid withdrawal. Retrieval of steroids brought complete resolution of the clinical and radiological findings. Although this syndrome is rare, it is recommended that steroid therapy in a patient previously irradiated to the chest be avoided.
Adenoid cystic carcinoma of bartholin's gland: Review of the literature and report of two cases
Authors: Abrao Fauzer S. , Marques Americo F. , Marziona Francisco , Abrao Mauricio S. , Junqueira Luis C. Uchoa , Torloni Humberto 
Published: February 2007

AbstractTwo patients with adenoid cystic carcinoma of Bartholin's gland and a review of the relevant literature are presented. With the inclusion of these two patients, there are now 24 cases reported. Both patients had large vulvar masses with a short clinical history, and several local tumor recurrences within the first 2½ years after radical vulvectomy. The characteristic cribriform pattern and perineural involvement in addition to vascular invasion were present in the pathological material. No metastases were found in the inguino‐femoral lymph nodes removed. Both patients are alive, without evidence of local recurrence but with lung metastases. A chemotherapeutic treatment scheme (adriamycin and cyclophosphamide) is underway but it is too early to evaluate its results.
Differentiation of jaundice in infancy: An application of radionuclide biliary studies
Authors: Johnston Gerald S. , Rosenbaum Richard C. , Hill J. Laurance , Diaconis John N. 
Published: February 2007

AbstractAtresia and hypoplasia of the bile ducts are the most common congenital biliary anomalies of clinical importance. Surgical correction can help about 10% of these infants. However, surgery should be performed within the first month of life to avoid irreversible liver parenchymal changes. It is difficult to separate the surgical condition, biliary atresia, from conditions in which the trauma of laparotomy should be avoided, such as neonatal hepatitis and other clinically indistinguishable causes of obstructive jaundice. Radionuclide imaging with the 99mTc‐labeled N‐substituted iminodiacetic acids (HIDA, PIDIDA, DISIDA, etc) have been helpful in the differential diagnosis of biliary atresia.
Production of murine monoclonal antibodies against cell‐surface antigens of human ovarian carcinoma
Authors: Bhattacharya Malaya , Chatterjee Sunil K. , Gangopadhyay Aniruddha , Barlow Joseph J. 
Published: February 2007

AbstractSplenic lymphocytes of BALB/c mice immunized with human ovarian carcinoma cells were fused with the mouse myeloma cell line, NS‐1 in the presence of polyethylene glycol, MW 1500. The hybrid cultures were screened by a viable cell‐binding radioimmunoassay (RIA) for the production of relevant antibodies. Hybrids that produced antibodies that bound to the surface of the immunizing cell line and other ovarian carcinoma cell lines, but not to human fibroblast cell lines or erythrocytes and leucocytes isolated from peripheral blood, were cloned twice by the limiting dilution method. Two such clones designated 8C3, of the IgG2a isotype, and 10D6, of the IgG1 isotype, were checked for specificity by a solid‐phase membrane RIA. The monoclonal antibodies (MoAbs) recognized an antigenic determinant present on different human adenocarcinomas such as ovary, breast, endometrium, colon, and stomach. The normal counterpart tissues of these histiotypes showed negligible binding to the MoAbs. The relative specificity of these MoAbs encourage further studies towards their characterization and evaluation as possible diagnostic and therapeutic agents in human cancer.
Advances in the diagnosis and treatment of EBV‐associated lymphoproliferative diseases in immunocompromised hosts
Authors: Hanto Douglas W. , Najarian John S. 
Published: February 2007

AbstractThe clinical, immunopathologic, and virologic features of the lymphoproliferative diseases occurring after renal transplantation have been characterized. Clinically, patients may present with an infectious mononucleosis‐like illness or with localized solid tumor masses. These lymphoproliferative diseases have unique histologic features that can be classified as polymorphic diffuse B‐cell hyperplasia (PDBH) or polymorphic B‐cell lymphoma (PBL). Immunologic cell‐typing studies have shown that the majority are polyclonal B‐cell proliferations, but monoclonal B‐cell tumors have also been documented. These B‐cell proliferations may, however, evolve from a benign polyclonal B‐cell hyperplasia to a monoclonal malignant lymphoma. The Epstein‐Barr virus (EBV) has been implicated as the cause of these disorders. Serologic studies frequently demonstrate evidence of a primary or reactivation infection, touch imprints from involved tissue may stain for the presence of EBNA (Epstein‐Barr nuclear antigen), and EBV DNA hybridization studies demonstrate the presence of EBV‐specific DNA sequences within tumor cells. Since EBV induces a polyclonal B‐cell proliferation in vitro and in vivo, the polyclonality of these diseases also implicates EBV. Acyclovir, a new synthetic antiviral agent that inhibits EBV DNA replication may be effective in some patients during the polyclonal growth phase but is ineffective once the tumor evolves into a monoclonal lymphoma. We have identified several factors that may be useful in predicting responsiveness to acyclovir therapy.
Systemic mastocytosis with extensive large cutaneous mastocytomas: Surgical management
Authors: McDermott William V. , Topol Bruce M. 
Published: February 2007

AbstractA case of systemic mastocytosis is reported with an observation period of 20 years. During these two decades multiple manifestations of the disease appeared including urticaria pigmentosis, episodic histamine release, gastro‐intestinal involvement and hepatosplenomegaly.The most extraordinary, and possibly unique phenomenon, has been the development of a massive proliferation of large mastocytomas mainly, but not exclusively, limited to the lower extremities. For different reasons (mechanical disability, bleeding, cosmesis), these tumors have required repeated admissions for surgical removal. The most successful technique has involved use of the ultrasonic scalpel.