bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electrical impedance scanning as a new breast cancer risk stratification tool for young women
Authors: Stojadinovic Alexander , Nissan Aviram , Shriver Craig D. , Mittendorf Elizabeth A. , Akin Mark D. , Dickerson Vivian , Lenington Sarah , Platt Lawrence D. , Stavros Thomas , Goldstein Steven R. , Moskovitz Orah , Gallimidi Zahava , Fields Scott I. , Yeshaya Arieh , Allweis Tanir M. , Manassa Raymond , Pappo Itzhak , Ginor Ron X. , D'Agostino Ralph B. , Gur David 
Published: November 2007

AbstractBackgroundElectrical impedance scanning (EIS) measures changes in breast tissue associated with breast cancer (Br‐Ca) development. The T‐Scan(tm2000 (ED is designed to use EIS to identify women ages 30–39 with elevated risk of breast cancer (i.e., T‐Scan+ women).AimTo estimate the relative probability of breast cancer in a T‐Scan+ woman compared to a randomly selected young woman.MethodsA prospective, two‐cohort trial was conducted in pre‐menopausal women. The Specificity (Sp)‐Cohort evaluated T‐Scan specificity in 1,751 asymptomatic women ages 30–39. The Sensitivity)Sn)‐Cohort evaluated T‐Scan sensitivity in 390 women ages 45–30 scheduled for biopsy. Specificity, sensitivity, and conservative estimate of disease prevalence were used to calculate relative probability.ResultsIn the Sp‐Cohort, 93 of 1,751 women were T‐Scan+ (Sp = 94.7%; 95% CI: 93.7–95.7%). In the Sn‐Cohort, 23 of 87 biopsy‐proven cancers were T‐Scan+ (Sn = 26.4%; 95% CI: 17.4–35.4%). Given Sp = 94.7%, Sn = 26.4% and prevalence of 1.5 cancers/1,000 women (ages 30–39), the relative probability of a T‐Scan+ woman having Br‐Ca is 4.95: (95% CI: 3.16–7.14).ConclusionEIS can identify a subset of young women with a relative probability of breast cancer almost five times greater than in the population of young women at‐large. T‐Scan+ women have a sufficiently high risk of Br‐Ca to warrant further surveillance or imaging. J. Surg. Oncol. 2008;97:112–120. © 2007 Wiley‐Liss, Inc.
Predictors and outcomes of recurrent disease after a negative second look laparotomy
Authors: Ayhan Ali , Gultekin Murat , Dursun Polat , Dogan Nasuh Utku , Aksan Guldeniz , Guven Suleyman , Yuce Kunter 
Published: November 2007

AbstractBackground and ObjectivesTo analyze the predictors and outcomes of recurrent disease in patients with epithelial ovarian carcinoma (EOC) after a negative second look laparotomy (SLL).MethodsOne hundred nine EOC patients with a negative SLL treated at Hacettepe Hospital were retrospectively analyzed.ResultsOf these patients, 70 (64.2%) had no evidence of disease during follow up while remaining 39 (35.8%) had recurrence. Majority of the recurrences (82.1%) were detected within the initial 2 years of the SLL procedure. Multivariate analysis revealed stage and grade of the disease to be the significant predictors for the recurrent disease (P < 0.01 and P = 0.025, respectively). A second analysis with respect to initial metastatic sites revealed omental metastatis was significantly associated with recurrent disease (P < 0.001). Survival of patients with a recurrent disease was significantly poorer and dropped abruptly once a recurrence is developed.ConclusionsPatients with initial omental metastasis, advanced stage and high grade tumors have highest risk for developing recurrences after a (−) SLL. Most of the recurrences develop during the initial 2 years following the (−) SLL and survival drops to less than 2 years once a recurrence is found. J. Surg. Oncol. 2008;97:226–230. © 2007 Wiley‐Liss, Inc.
Function, disability, and health‐related quality of life after allograft‐prosthesis composite reconstructions of the proximal femur
Authors: Biau David J. , Davis Aileen , Vastel Laurent , Tomeno Bernard , Anract Philippe 
Published: November 2007

AbstractBackgroundFactors affecting function, disability and health‐related quality of life after allograft‐prosthesis composite reconstructions have been poorly studied.MethodsRetrospective study of eighteen patients who underwent reconstruction with proximal femoral allograft‐prosthesis composites and answered questionnaires to assess hip function (Postel and Merle d'Aubigné, self‐reported Harris Hip Score), disability (Toronto Extremity Salvage Score), and health‐related quality of life (SF‐36).ResultsThe median Toronto Extremity Salvage Score was 76 (IQR: 48–85), the median self‐reported Harris Hip Score was 90 (IQR: 48–95) and the median Postel and Merle d'Aubigné score was 17 (IQR: 12–17). Older age, female gender, and presentation with a pathologic fracture were associated with increased disability and poorest function. The median Physical Component Summary score was 44 (IQR: 39–45) and Mental Component Summary scores were 49 (IQR: 46–56). Male gender and recurrence of disease were associated with poorer health‐related quality of life. There was a high degree of correlation between function, disability scores and Physical Component Summary score.ConclusionsPatients' characteristics at presentation such as age, gender, and occurrence of a pathologic fracture play an important role in determining disability, function, and health‐related quality of life after allograft‐prosthesis composite reconstruction of the proximal femur. J. Surg. Oncol. 2008;97:210–215. © 2007 Wiley‐Liss, Inc.
Extended left‐sided pancreatectomy with spleen preservation
Authors: Mohebati Arash , Schwarz Roderich E. 
Published: November 2007

AbstractBackgroundDistal pancreatectomy (DP) is frequently performed with splenectomy, although splenectomy can be linked to various untoward effects, and sparing of the main splenic vessels (SVs) is not necessary for successful spleen preservation (SP).MethodsWe reviewed all DPs in a single‐surgeon practice to assess feasibility and outcomes of SP.ResultsBetween 1997 and 2007, 41 of 177 pancreatic resections involved a DP (23%). There were 14 men (34%) and 27 women (66%), with a median age of 60 years (range: 34–86). Four procedures were en bloc resections, two total pancreatectomies, while eight of the remaining 35 DPs were performed laparoscopically. SP was accomplished in 33 of 34 possible cases (SP rate 97%), despite SV resection in 27 of these (82%). The postoperative complication rate was 24%, without death. Pancreatic fistulae occurred in two patients (5% of patients at risk), and one SPDP led to splenic infarct. No other clinically relevant problems specific to SP have become apparent.ConclusionsPancreatic fistula rate and other outcomes in this small DP experience compare favorably to other DP series. Few spleen‐specific complications and the radicality of resection support the liberal use of SP with SV resection, irrespective of an open or laparoscopic approach. J. Surg. Oncol. 2008;97:150–155. © 2007 Wiley‐Liss, Inc.
1H and 13C NMR assignments for the sesquiterpene aldehydes, lepidozenal and isobicyclogermacrenal, from Eucalyptus dawsonii
Authors: Tucker David J. , Southwell Ian A. , Lowe Robert F. , Russell Michael F. , Brereton Ian M. 
Published: November 2007

AbstractLepidozenal and isobicyclogermacrenal were isolated from the leaves of Eucalyptus dawsonii and a complete assignment of their 1H and 13C NMR spectra was carried out using 2D NMR methods. Copyright © 2007 John Wiley & Sons, Ltd.
Disorder in condensed matter systems: proton spin lattice relaxation study of the mixed systems of betaine phosphate and glycine phosphite, BPxGPI(1−x)
Authors: Ramanuja M. N. , Ramesh K. P. , Ramakrishna J. 
Published: November 2007

AbstractProton NMR relaxation measurements have been carried out in the mixed system of antiferroelectric (AFE) betaine phosphate (BP) and ferroelectric (FE) glycine phosphite (GPI), BPxGPI(1−x), at 11.4 and 23.3 MHz from 300 to 100 K for x = 0.3, 0.4, 0.5, 0.6, 0.7 and 0.8. The temperature dependence of spin lattice relaxation (SLR) time follows the BPP model in the parent compounds, while the Larmor frequency dependence of T1 in the mixed system is rather unusual. The T1 curve exhibits different slopes for the low‐temperature wings at the two frequencies, which is a clear experimental evidence of the presence of different methyl groups with different activation energies (Ea), indicating disorder. For x = 0.3 and 0.4, biexponential recovery of magnetization has been observed below 190 K, showing that the degree of disorder varies with the concentration. The temperature dependence of relaxation time data has been interpreted in terms of NH3, trimethyl ammonium and methyl group reorientations. Copyright © 2007 John Wiley & Sons, Ltd.
Complete 1H and 13C NMR assignments of three new polyhydroxylated sterols from the South China Sea gorgonian Subergorgia suberosa
Authors: Qi Shu‐Hua , Zhang Si , Wang Yi‐Fei , Li Ming‐Yi 
Published: November 2007

AbstractThree new polyhydroxylated sterols, 3β,6α,11,20β,24‐pentahydroxy‐ 9,11‐seco‐5α‐24‐ethylcholest‐7,28‐diene‐9‐one (1), 3‐(1′,2′‐ethandiol)‐24‐ methylcholest‐8(9),22E‐diene‐3β,5α,6α,7α,11α‐pentaol (2), 24‐methylcholest‐7,22 E‐diene‐3β,5α,6β,25‐tetraol (3) together with five known sterols, were isolated from the EtOH/CH2Cl2 extract of the South China Sea gorgonian Subergorgia suberosa. The complete assignments of the 1H and 13C NMR chemical shifts for these new compounds were achieved by means of 1D and 2D NMR techniques, including HSQC, HMBC, 1H1H COSY, and NOESY spectra. Copyright © 2007 John Wiley & Sons, Ltd.
Quantitative assessment of intervertebral disc glycosaminoglycan distribution by gadolinium‐enhanced MRI in orthopedic patients
Authors: Vaga Stefania , Raimondi Manuela Teresa , Caiani Enrico Gianluca , Costa Francesco , Giordano Carmen , Perona Franco , Zerbi Alberto , Fornari Maurizio 
Published: November 2007

AbstractOur hypothesis was that the enhanced MRI of cartilage (dGEMRIC) imaging protocol could be used in patients to quantify the sulfated glycosaminoglycan (sGAG) in intervertebral discs (IVD). To test this hypothesis, 23 patients with degenerative disc pathology scheduled for surgery were studied by a specific dGEMRIC protocol: each patient underwent two MRI scans, before and 3.5 hr after Gd(DTPA)2‐injection of a nonconventional dose of 40 mL. Then, T1PRE‐ENH and T1POST‐ENH parametric images of the disc were obtained, from which a new index ΔT1 of the molecular status of the IVD was computed (T1PRE‐ENH − T1POST‐ENH). A total of 31 tissue samples (one or two from each patient) obtained at herniectomy were collected and biochemically analyzed for sGAG content and used as the gold standard for comparison. ΔT1 values in correspondence to degenerated sectors were higher (158 ± 36 ms) compared to normal sectors (80 ± 13 ms). Linear regression analysis between MRI‐derived and biochemistry‐derived measurements resulted in a significant correlation (r = 0.73, P < 0.0001). The ΔT1 parametric images, calculated using the modified dGEMRIC technique, provided noninvasive quantitative information about sGAG content within discal tissue in vivo, which resulted in agreement with biochemical analysis. The application of this new MRI method could provide diagnostic information for standard treatment of lumbar discopathy and for innovative therapies of regenerative medicine. Magn Reson Med, 2007. © 2007 Wiley‐Liss, Inc.
Measurement of glycine in human brain by triple refocusing 1H‐MRS in vivo at 3.0T
Authors: Choi Changho , Bhardwaj Paramjit P. , Seres Peter , Kalra Sanjay , Tibbo Philip G. , Coupland Nicholas J. 
Published: November 2007

AbstractA new 1H‐MRS filtering strategy for selective measurement of glycine (Gly) in human brain in vivo at 3.0T is proposed. Investigation of multiple refocusing following a 90° excitation pulse indicated that triple refocusing is most effective for suppression of the strongly coupled resonances of myo‐inositol (mI) at the Gly 3.55‐ppm resonance. The echo times of the triple refocusing were optimized, with numerical analysis of the filtering performance, as {TE1, TE2, TE3} = {67, 62, 69} ms. Compared with the 90°‐acquired mI signal the mI suppression ratios of the filter were 170 and 1000, in terms of peak amplitude and area, respectively, between 3.51 and 3.59 ppm. From LCModel analyses, using density‐matrix calculated spectra as basis functions, the concentration of Gly in parieto‐occipital cortex of healthy adults was estimated to be 0.5 ± 0.1 mM (mean ± SD, n = 6), with reference to creatine at 8 mM. Magn Reson Med, 2007. © 2007 Wiley‐Liss, Inc.
Displacement encoding for the measurement of cartilage deformation
Authors: Neu Corey P. , Walton Jeffrey H. 
Published: November 2007

AbstractArticular cartilage is a load bearing and lubricating tissue in animal joints. Heterogeneous deformations arise in the structured and zonal tissue under the application of mechanical load. The character of these deformations is altered by degenerative joint disease. Here, we document an MRI‐based technique for determining deformations throughout the volume of the tissue based on displacement encoding with stimulated echoes (DENSE) and a fast spin echo (FSE) readout. A DENSE‐FSE technique was designed to image cartilage at 9.4 Tesla in a deformed state during the application of cyclic mechanical loading. Artifact elimination arising from stimulated echoes and FSE was accomplished by radio frequency pulse phase cycling. The error of the technique was random and was quantified in terms of precision as better than 0.17% strain. Heterogeneous deformation field patterns in axial, transverse, and shear directions were quantified in a single tissue explant loaded in simple uniaxial compression. The technique is appropriate for documenting tissue deformations during applied physiologically relevant stress levels and loading rates. It may also be applied to characterize the micromechanical strain environment in normal, diseased, or regenerated cartilage in response to applied mechanical loading. Magn Reson Med, 2007. © 2007 Wiley‐Liss, Inc.
Extracellular matrix signature identifies breast cancer subgroups with different clinical outcome
Authors: Bergamaschi A , Tagliabue E , Sørlie T , Naume B , Triulzi T , Orlandi R , Russnes HG , Nesland JM , Tammi R , Auvinen P , Kosma V‐M , Ménard S , Børresen‐Dale A‐L 
Published: November 2007

AbstractPrediction of the clinical outcome of breast cancer is multi‐faceted and challenging. There is growing evidence that the complexity of the tumour micro‐environment, consisting of several cell types and a complex mixture of proteins, plays an important role in development, progression, and response to therapy. In the current study, we investigated whether invasive breast tumours can be classified on the basis of the expression of extracellular matrix (ECM) components and whether such classification is representative of different clinical outcomes. We first examined the matrix composition of 28 primary breast carcinomas by morphology and gene expression profiling using 22K oligonucleotide Agilent microarrays. Hierarchical clustering of the gene expression profile of 278 ECM‐related genes derived from the literature divided the tumours into four main groups (ECM1–4). A set of selected differentially expressed genes was validated by immunohistochemistry. The robustness of the ECM classification was confirmed by studying the four ECM groups in a previously published gene expression data set of 114 early‐stage primary breast carcinomas profiled using cDNA arrays. Univariate survival analysis showed significant differences in clinical outcome among the various ECM subclasses. One set of tumours, designated ECM4, had a favourable outcome and was defined by the overexpression of a set of protease inhibitors belonging to the serpin family, while tumours with an ECM1 signature had a poorer prognosis and showed high expression of integrins and metallopeptidases, and low expression of several laminin chains. Furthermore, we identified three surrogate markers of ECM1 tumours: MARCO, PUNC, and SPARC, whose expression levels were associated with breast cancer survival and risk of recurrence. Our findings suggest that primary breast tumours can be classified based upon ECM composition and that this classification provides relevant information on the biology of breast carcinomas, further supporting the hypothesis that clinical outcome is strongly related to stromal characteristics. Copyright © 2007 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Opposite pathobiochemical fate of pyruvate kinase and adenylate kinase in aged rat skeletal muscle as revealed by proteomic DIGE analysis
Authors: Doran Philip , O'Connell Kathleen , Gannon Joan , Kavanagh Marcella , Ohlendieck Kay 
Published: November 2007

AbstractSarcopenia is the drastic loss of skeletal muscle mass and strength during ageing. In order to better understand the molecular pathogenesis of age‐related muscle wasting, we have performed a DIGE analysis of young adult versus old rat skeletal muscle. Proteomic profiling revealed that out of 2493 separated 2‐D spots, 69 proteins exhibited a drastically changed expression. Age‐dependent alterations in protein abundance indicated dramatic changes in metabolism, contractile activity, myofibrillar remodelling and stress response. In contrast to decreased levels of pyruvate kinase (PK), enolase and phosphofructokinase, the mitochondrial ATP synthase, succinate dehydrogenase, malate dehydrogenase, isocitrate dehydrogenase and adenylate kinase (AK) were increased in senescent fibres. Higher expression levels of myoglobin and fatty acid binding‐protein indicated a shift to more aerobic‐oxidative metabolism in a slower‐twitching aged fibre population. The drastic increase in αB‐crystallin and myotilin demonstrated substantial filament remodelling during ageing. An immunoblotting survey of selected muscle proteins confirmed the pathobiochemical transition process in aged muscle metabolism. The proteomic analysis of aged muscle has identified a large cohort of new biomarkers of sarcopenia including opposite changes in PK and AK, which might be useful for the design of improved diagnostic procedures and/or therapeutic strategies to counteract ageing‐induced muscle degeneration.
Corrigendum: Effect of electronic compensation on plethysmographic airway resistance measurements
Authors: Broughton Simon , Rafferty Gerrard F. , Milner Anthony D. , Greenough Anne 
Published: November 2007

AbstractThe original article to which this Erratum refers was published in Pediatric Pulmonology 2007;42(9):764–772/DOI 10.1002/ppul.20661. © 2007 Wiley‐Liss, Inc.
Structure‐based design of a bicyclic peptide antagonist of the vascular endothelial growth factor receptors
Authors: Goncalves Victor , Gautier Benoit , Garbay Christiane , Vidal Michel , Inguimbert Nicolas 
Published: November 2007

AbstractDysregulated angiogenesis is implicated in several pathologies, including cancer and age‐related macular degeneration. A potential antiangiogenic strategy consists in developing VEGF receptor ligands capable of preventing VEGF binding and the subsequent activation of these receptors. Herein, we describe the structure‐based design of a VEGF‐mimicking peptide, VG3F. This 25‐mer peptide was doubly cyclized, on‐resin, by formation of both a disulfide bridge and an intramolecular amide bond to constrain it to adopt a bioactive conformation. Tested on in vitro assays, VG3F was able to prevent VEGF binding to VEGF receptor 1 and inhibit both VEGF‐induced signal transduction and cell migration. Copyright © 2007 European Peptide Society and John Wiley & Sons, Ltd.
Controlled disassembly of peptide amphiphile fibres
Authors: Löwik Dennis W. P. M. , Meijer Joris T. , Minten Inge J. , van Kalkeren Henri , Heckenmüller Lisa , Schulten Ines , Sliepen Kwinten , Smittenaar Peter , van Hest Jan C. M. 
Published: November 2007

AbstractIn this paper, the introduction of both a methionine residue and a nitrobenzyl derivative as a labile linker between the peptide part and the hydrophobic alkyl chain of a peptide amphiphile are presented. These modifications are shown not to inhibit the formation of structured assemblies that analogous peptide amphiphiles lacking the linkers are able to form. Moreover, the introduction of either labile linker allows removal of the peptide amphiphile's stabilizing hydrophobic moieties to initiate a controlled disassembly of fibre aggregates. This is achieved by either treatment with CNBr or UV irradiation, respectively. These disassembly mechanisms could be the starting point for methodology that allows further manipulation of self‐assembled peptide amphiphile architectures. Copyright © 2007 European Peptide Society and John Wiley & Sons, Ltd.
Exact method to solve the Boltzmann equation to any order in the driving forces: Application to transport parameters
Authors: Brugger S. C. , Peikert V. , Schenk A. 
Published: November 2007

AbstractIn this paper a method to compute transport parameters in semiconductor devices as a function of the driving forces is presented. The method is based on an exact expansion of the distribution function (solution of the Boltzmann transport equation) in a series in the electric field and the gradient of the quasi‐Fermi potential. Eventhough this series probably diverges for high fields, it is still usable for low and moderate field intensities. Results for silicon clearly show that the usual parametrization of the mobility in TCAD models is inaccurate in pn junctions. Furthermore, it gives new insights into the form of the correct parametrization. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Coherent pseudo‐spin resonance in a laterally coupled double quantum dot
Authors: Kubo Toshihiro , Tokura Yasuhiro , Tarucha Seigo 
Published: November 2007

AbstractIn a laterally coupled double quantum dot (DQD), we can refer to the tunnel‐coupled symmetric (antisymmetric) state as the pseudo‐spin up (down) state. We study the coherent pseudo‐spin dynamics in a laterally coupled DQD. We propose the blockade phenomena induced by quantum interference effect through the pseudo‐spin states. Under such a blockade condition, we calculate the leakage current due to the coherent pseudospin dynamics driven by time‐varying microwave (MW) fields. When the resonant condition is satisfied, the current has a peak (right figure). Moreover, we examine the effect of the photon‐assisted‐tunneling (PAT) on pseudospin dynamics. We show that the PAT does not significantly influence the leakage current under above blockade condition. The frequency and the inter‐dot tunnel coupling dependence of the leakage current. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Energy distribution of the ballistic hot electrons and holes emitted from a quantum point contact and probed by a quantum dot
Authors: Kobayashi T. , Sasaki S. , Fujisawa T. , Tokura Y. , Akazaki T. 
Published: November 2007

AbstractWe present measurements on the energy distribution profile of the ballistic hot carriers emitted from a quantum point contact. The hot carriers were injected to a quantum dot using magnetic focusing technique and analyzed by measuring differential conductance of the quantum dot. We found a thermally broadened energy distribution of the hot carriers near the bias voltage applied to the quantum point contact in an otherwise uniform distribution down to the equilibrium Fermi energy. We also measured an occupation ratio of available states by the injected hot carriers, and fully characterized their energy distribution profile. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)