bluuebunny/crossref_metadata_2025_split huggingface dataset:
Solutions Trial: Solution Focused Brief Therapy (SFBT) in 10–17-year-olds presenting at police custody: a randomised controlled trial
Authors: Moody Gwenllian , Coulman Elinor , Crocker-White Emma , Gray Kylie , Hastings Richard P. , Longman Andrea , Lugg-Widger Fiona , Playle Rebecca , Segrott Jeremy , Thompson Paul , Badger Julia , Langdon Peter E. , Flynn Samantha 
Published: March 2024

Abstract
Background
Within England, children and young people (CYP) who come into police custody are referred to Liaison and Diversion (L&D) teams. L&D teams have responsibility for liaising with healthcare and other support services while working to divert CYP away from the criminal justice system but have traditionally not provided targeted psychological interventions to CYP. Considering evidence that Solution Focused Brief Therapy (SFBT) leads to a reduction in internalising and externalising behaviour problems in CYP, the aim of this randomised controlled trial (RCT) was to determine whether there is a difference between services as usual (SAU) plus SFBT offered by trained therapists working within a L&D team, and SAU alone, in reducing offending behaviours in 10–17-year-olds presenting at police custody.

Methods
Design: two-arm individually RCT with internal pilot and process evaluation.
Participants: N = approximately 448 CYP aged 10–17 years presenting at one of three police custody suites in the area served by Lancashire and South Cumbria NHS Foundation Trust (LSCFT) who are referred to the L&D team. Participants will be recruited and allocated to intervention:control on a 1:1 basis. Interviews will be performed with 30–40 CYP in the intervention arm, 15 CYP in the control arm, up to 20 parents/guardians across both arms, up to 15 practitioners, and up to 10 site staff responsible for screening CYP for the trial.
Intervention and control: Those allocated to the intervention will be offered SAU plus SFBT, and control participants will receive SAU only.
Primary outcome: CYP frequency of offending behaviours assessed through the Self-Report Delinquency Measure (SRDM) at 12 months post-randomisation.
Secondary outcomes: criminal offence data (national police database); emotional and behavioural difficulties (self-report and parent/guardian reported); gang affiliation (self-report).
Process evaluation: evaluation of acceptability and experiences of the CYP, parents/guardians, site staff and practitioners; fidelity of SFBT delivery.

Discussion
This two-arm individually RCT will evaluate the effectiveness of SFBT in reducing offending behaviours in CYP presenting at police custody suites within the area served by LSCFT. Our process evaluation will assess the fidelity of delivery of SFBT, the factors affecting implementation, the acceptability of SFBT in CYP aged 10–17 years and recruitment and reach. We will also examine systems and structures for future delivery, therefore assessing overall scalability.

Trial registration
ClinicalTrials.gov ISRCTN14195235. Registered on June 16, 2023.
Coenzyme Q10 supplementation in burn patients: a double-blind placebo-controlled randomized clinical trial
Authors: Kiani Zahra , Khorsand Nadereh , Beigi Fahimeh , Askari Gholamreza , Sharma Manoj , Bagherniya Mohammad 
Published: March 2024

Abstract
Background
Burn injuries are important medical problems that, aside from skin damage, cause a systemic response including inflammation, oxidative stress, endocrine disorders, immune response, and hypermetabolic and catabolic responses which affect all the organs in the body. The aim of this study was to determine the effect of coenzyme Q10 (CoQ10) supplementation on inflammation, oxidative stress, and clinical outcomes in burn patients.

Methods
In a double-blind placebo-controlled randomized clinical trial, 60 burn patients were randomly assigned to receive 100 mg CoQ10 three times a day (total 300 mg/day) or a placebo for 10 days. Inflammatory markers including erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), oxidative stress markers including total antioxidant capacity (TAC), malondialdehyde (MDA) and superoxide dismutase (SOD) activity, fasting blood glucose (FBG), blood urea nitrogen (BUN), creatinine, white blood cells (WBC), and body temperature were assessed as primary outcomes and albumin, prothrombin time (PT), partial thromboplastin time (PTT), international normalized ratio (INR), other hematological parameters, blood pressure, O2 saturation, ICU duration, and 28-mortality rate were assessed as secondary outcomes.

Results
Fifty-two participants completed the trial. CRP and ESR levels were not significantly different between CoQ10 and placebo groups at the end of the study (P = 0.550 and P = 0.306, respectively). No significant differences between groups were observed for TAC (P = 0.865), MDA (P = 0.692), and SOD activity (P = 0.633) as well. Administration of CoQ10 resulted in a significant increase in albumin levels compared to placebo (P = 0.031). There was no statistically significant difference between the two groups in other measured outcomes (P > 0.05).

Conclusion
Results showed that in patients with burn injury, CoQ10 administration had no effect on inflammatory markers and oxidative stress, although serum albumin levels were improved after supplementation. Further studies with albumin as the primary outcome are needed to confirm this finding.
An analysis of transition-resulted goal scoring patterns in football leagues: a comparison of the first 5 rounds and the last 5 rounds prior midway of the season
Authors: Eusebio Pedro , Prieto-González Pablo , Marcelino Rui 
Published: March 2024

Abstract
Objective
This study investigated the concept of ‘game style’ in football, focusing on a team’s distinctive approach characterized by tactics, formations, and strategies. The objective is to compare goal-scoring patterns related to “non-offensive transition,” “set pieces,” “offensive transition,” and “positive outcomes” across different league groups. Methodology: The sample comprises 702 football games, categorized into three league groups: Top Leagues, Marginal Leagues, and Emerging Leagues. A total of 2140 goals were analyzed, classifying them into four types: “No Transitions”, “Set Pieces”, “Offensive Transitions (direct), and “Positive Outcomes” of offensive transitions. The study aims to identify relevant differences between two distinct competitive periods, namely “Rounds 1 to 5” and “Rounds Last 5.” Results: The analysis reveals no significant differences in scoring methods between “Rounds 1 to 5” and “Rounds Last 5” across all variables in the analyzed league groups, except for goals conceded by “No Transition” in the Emerging Leagues. Additionally, results indicate that goals resulting from direct offensive transitions and positive outcomes substantially impact the Top Leagues, constituting 54% of the total scoring. Conclusion: The study emphasizes the importance of establishing and maintaining consolidated game patterns, as demonstrated by the consistent scoring patterns across different league groups. While most leagues show no variations in scoring methods between early and late rounds, attention to goals conceded by “No Transition” in Emerging Leagues is warranted. The prominence of direct offensive transitions and positive outcomes in Top Leagues highlights the relevance of these strategies in the scoring process, emphasizing the need for teams to focus on developing and implementing effective game patterns.
Significant reduction of activity retention in the kidneys via optimized linker sequences in radiohybrid-based minigastrin analogs
Authors: Holzleitner Nadine , Fischer Sebastian , Maniyankerikalam Isabel , Beck Roswitha , Lapa Constantin , Wester Hans-Jürgen , Günther Thomas 
Published: March 2024

Abstract
Background
We recently introduced radiohybrid (rh)-based minigastrin analogs e.g., DOTA-rhCCK-18 (DOTA-D-Dap(p-SiFA)-(D-γ-Glu)8-Ala-Tyr-Gly-Trp-Nle-Asp-Phe-NH2), that revealed substantially increased activity retention in the tumor. However, one major drawback of these first generation rh-based cholecystokinin-2 receptor (CCK-2R) ligands is their elevated activity levels in the kidneys, especially at later time points (24 h p.i.). Therefore, this study aimed to reduce kidney retention with regard to a therapeutic use via substitution of negatively charged D-glutamic acid moieties by hydrophilic uncharged polyethylene glycol (PEG) linkers of various length ((PEG)4 to (PEG)11). Furthermore, the influence of differently charged silicon-based fluoride acceptor (SiFA)-moieties (p-SiFA: neutral, SiFA-ipa: negatively charged, and SiFAlin: positively charged) on in vitro properties of minigastrin analogs was evaluated. Out of all compounds evaluated in vitro, the two most promising minigastrin analogs were further investigated in vivo.

Results
CCK-2R affinity of most compounds evaluated was found to be in a range of 8–20 nM (by means of apparent IC50), while ligands containing a SiFA-ipa moiety displayed elevated IC50 values. Lipophilicity was noticeably lower for compounds containing a D-γ-glutamate (D-γ-Glu) moiety next to the D-Dap(SiFA) unit as compared to their counterparts lacking the additional negative charge. Within this study, combining the most favorable CCK-2R affinity and lipophilicity, [177/natLu]Lu-DOTA-rhCCK-70 (DOTA-D-Dap(p-SiFA)-D-γ-Glu-(PEG)7-D-γ-Glu-(PEG)3-Trp-(N-Me)Nle-Asp-1-Nal-NH2; IC50: 12.6 ± 2.0 nM; logD7.4: − 1.67 ± 0.08) and [177/natLu]Lu-DOTA-rhCCK-91 (DOTA-D-Dap(SiFAlin)-D-γ-Glu-(PEG)4-D-γ-Glu-(PEG)3-Trp-(N-Me)Nle-Asp-1-Nal-NH2; IC50: 8.6 ± 0.7 nM; logD7.4 =  − 1.66 ± 0.07) were further evaluated in vivo. Biodistribution data of both compounds revealed significantly reduced (p < 0.0001) activity accumulation in the kidneys compared to [177Lu]Lu-DOTA-rhCCK-18 at 24 h p.i., leading to enhanced tumor-to-kidney ratios despite lower tumor uptake. However, overall tumor-to-background ratios of the novel compounds were lower than those of [177Lu]Lu-DOTA-rhCCK-18.

Conclusion
We could show that the reduction of negative charges within the linker section of radiohybrid-based minigastrin analogs led to decreased activity levels in the kidneys at 24 h p.i., while maintaining a good tumor uptake. Thus, favorable tumor-to-kidney ratios were accomplished in vivo. However, further optimization has to be done in order to improve tumor retention and general biodistribution profile.

Graphical abstract
Two intestinal microbiota-derived metabolites, deoxycholic acid and butyrate, synergize to enhance host defense peptide synthesis and alleviate necrotic enteritis
Authors: Kim Dohyung M. , Liu Jing , Whitmore Melanie A. , Tobin Isabel , Zhao Zijun , Zhang Guolong 
Published: March 2024

Abstract
Background
Necrotic enteritis (NE) is a major enteric disease in poultry, yet effective mitigation strategies remain elusive. Deoxycholic acid (DCA) and butyrate, two major metabolites derived from the intestinal microbiota, have independently been shown to induce host defense peptide (HDP) synthesis. However, the potential synergy between these two compounds remains unexplored.

Methods
To investigate the possible synergistic effect between DCA and butyrate in regulating HDP synthesis and barrier function, we treated chicken HD11 macrophage cells and jejunal explants with DCA and sodium butyrate (NaB), either individually or in combination, for 24 h. Subsequently, we performed RNA isolation and reverse transcription-quantitative PCR to analyze HDP genes as well as the major genes associated with barrier function. To further determine the synergy between DCA and NaB in enhancing NE resistance, we conducted two independent trials with Cobb broiler chicks. In each trial, the diet was supplemented with DCA or NaB on the day-of-hatch, followed by NE induction through sequential challenges with Eimeria maxima and Clostridium perfringens on d 10 and 14, respectively. We recorded animal mortality after infection and assessed intestinal lesions on d 17. The impact of DCA and NaB on the microbiota in the ileum and cecum was evaluated through bacterial 16S rRNA gene sequencing.

Results
We found that the combination of DCA and NaB synergistically induced multiple HDP genes in both chicken HD11 cells and jejunal explants. Additionally, the gene for claudin-1, a major tight junction protein, also exhibited synergistic induction in response to DCA and NaB. Furthermore, dietary supplementation with a combination of 0.75 g/kg DCA and 1 g/kg NaB led to a significant improvement in animal survival and a reduction in intestinal lesions compared to either compound alone in a chicken model of NE. Notably, the cecal microbiota of NE-infected chickens showed a marked decrease in SCFA-producing bacteria such as Bacteroides, Faecalibacterium, and Cuneatibacter, with lactobacilli becoming the most dominant species. However, supplementation with DCA and NaB largely restored the intestinal microbiota to healthy levels.

Conclusions
DCA synergizes with NaB to induce HDP and claudin-1 expression and enhance NE resistance, with potential for further development as cost-effective antibiotic alternatives.
Covid-19 psychological pressures, depression and FOMO: the mediating role of online social support and emotional regulation
Authors: Dong Yuting , Chen Min , Wu Zhigang , Zhang Zilin 
Published: March 2024

Abstract
Background
The spread of the coronavirus has led to significant anxiety among university students, resulting in various mental health problems that could potentially impact their academic performance.

Method
To examine the mediating role of emotional regulation and online social support in the relationships between COVID-19 psychological pressures, depression, and the fear of missing out (FoMO) among young adult university students, a cross-sectional research design was employed using an online survey. The sample consisted of 521 full-time university students from China, currently enrolled in undergraduate and postgraduate programs.

Results
Findings revealed that more than half (55.09%, n=287) of the university students experienced COVID-19 psychological pressures. These pressures directly contributed to increased levels of depression (β = 0.339, p < .001) and fear of missing out (β = 0.236, p < .001). Moreover, online social support and emotional regulation exhibited partial mediating effects on the association between COVID-19 psychological pressures, depression, and the fear of missing out. The results indicated that COVID-19 psychological pressures were linked to higher levels of depressive symptoms and a greater fear of missing out among university students.

Conclusions
However, the provision of timely and adequate online social support, as well as the implementation of emotional regulation strategies, mitigated the negative effects of the pandemic on students' social and emotional well-being. Consequently, this led to reduced levels of depression and fear of missing out.
COVID-19-Related distress, body image, and eating behaviors: a cross-sectional explanatory model
Authors: Rodrigue Christopher , Rodgers Rachel F. , Carbonneau Noémie , Bégin Catherine , Dion Jacinthe 
Published: March 2024

Abstract
Background
The COVID-19 pandemic has been associated with increased body dissatisfaction and disordered eating behaviors in adolescents. To better understand these associations, this study tested an explanatory model in which appearance-focused social media use, internalization of social media pressure, and mindfulness abilities mediated the relationship between COVID-related distress and body dissatisfaction, which in turn was associated with dietary restraint and binge eating episodes.

Methods
Adolescents (N = 493, Mage= 16.7; 47.5% girls) recruited within high schools completed online measures. We conducted model testing through path analysis in MPlus, using modification indices to derive a well-fitting model.

Results
The initially hypothesized model was a poor fit for the data. The final well-adjusted model confirmed several significant paths and supported the parallel mediational roles of social media (specifically, the use of appearance-focused social media and internalization of social media pressure) along with mindfulness, on the relationship between COVID-19-related distress and body satisfaction. Model adjustments involved adding three paths, resulting in two additional significant indirect effects, and suppressing one path.

Conclusions
Findings suggest that mindfulness, media use and the internalization of social media pressure are potential key processes explaining body dissatisfaction and eating disorders among adolescents who experienced higher levels of COVID-related distress.
Pre-job loss grief reactions and work attachment among sick-listed employees: Introduction of the imminent Job Loss Scale
Authors: van Eersel Janske H. W. , Hulshof Inge L. , Wickham Miriam I. , Smid Geert E. , Boelen Paul A. 
Published: March 2024

Abstract
Background
With this study, we aimed to explore the emotional experiences of sick-listed employees facing imminent job loss, as this emotional distress may hinder successful job search outcomes. The study had two objectives: (1) to develop and validate the Imminent Job Loss Scale (IJLS) for assessing pre-job loss grief reactions and (2) to examine its relationship to work attachment.

Methods
Development of the 9-item IJLS was carried out using feedback from an expert panel, consisting of five academic experts in grief and labour, five re-integration specialists, and five sick-listed employees facing imminent job loss. The psychometric properties of the IJLS were evaluated, and its association with work attachment was examined using data from 200 sick-listed employees facing imminent job loss.

Results
The IJLS demonstrated strong internal consistency and temporal stability, distinctiveness from depression and anxiety symptoms, and solid convergent validity. Work-centrality and organizational commitment were positively related to pre-job loss grief reactions, while work engagement and calling showed no significant associations.

Conclusion
This study provides valuable insights into pre-job loss grief reactions and shows the potential utility of the IJLS for screening and monitoring purposes. Understanding pre-job loss grief reactions can improve the re-integration and job prospects of sick-listed employees. In future research, explorations of these dynamics should continue to provide better support to sick-listed employees during this challenging period.
Technology for the formation of engineered microvascular network models and their biomedical applications
Authors: Li He , Shang Yucheng , Zeng Jinfeng , Matsusaki Michiya 
Published: March 2024

AbstractTissue engineering and regenerative medicine have made great progress in recent decades, as the fields of bioengineering, materials science, and stem cell biology have converged, allowing tissue engineers to replicate the structure and function of various levels of the vascular tree. Nonetheless, the lack of a fully functional vascular system to efficiently supply oxygen and nutrients has hindered the clinical application of bioengineered tissues for transplantation. To investigate vascular biology, drug transport, disease progression, and vascularization of engineered tissues for regenerative medicine, we have analyzed different approaches for designing microvascular networks to create models. This review discusses recent advances in the field of microvascular tissue engineering, explores potential future challenges, and offers methodological recommendations.
Automatic grasp planning for self-adjustable gripper frames
Authors: Cramer Jeroen , Cramer Martijn , Kellens Karel 
Published: March 2024

AbstractIn high-mix, low-volume manufacturing, end-of-arm tooling (EOAT) must be able to handle various products. Conventional EOATs usually comprise fixed or limited-adjustable frames (i.e. manually or using short-stroke pistons) over-equipped with multiple grippers, which are selectively activated based on the product to be grasped. This paper presents a smart gripper frame equipped with only four grippers capable of automatically adjusting to a product’s unique geometry. To this end, a two-dimensional grasp planner has been developed that is supplied with product contours from depth images. The proposed approach has been successfully validated in multiple industrial use cases involving objects with different dimensions and materials, and applying various grippers.
Bat pollinators: a decade of monitoring reveals declining visitation rates for some species in Thailand
Authors: Stewart Alyssa B. , Srilopan Supawan , Wayo Kanuengnit , Hassa Piriya , Dudash Michele R. , Bumrungsri Sara 
Published: March 2024

AbstractBats are important pollinators, but they are difficult to study since they are volant and nocturnal. Thus, long-term studies of nectarivorous bats are scarce, despite their potential to help assess trends in bat populations and their pollination services. We used capture rates of nectarivorous bats at chiropterophilous flowers in order to examine temporal trends in bat visitation in an area that is undergoing extensive land use change. We mist-netted at five bat-pollinated plant taxa (Durio zibethinus, Musa acuminata, Oroxylum indicum, Parkia speciosa, and Sonneratia spp.) in southern Thailand over six years between 2011 and 2021. We found that the most common bat species, Eonycteris spelaea, was the main visitor at all five plant taxa and had consistent visitation rates across all study years. In contrast, two other important pollinators, Macroglossus minimus and M. sobrinus, showed 80% declines in the number of individuals netted at mangrove apple (Sonneratia spp.) and banana (Musa acuminata) flowers, respectively. These findings suggest that E. spelaea (a large, cave-roosting species with a broad diet) is more tolerant of anthropogenic change than are Macroglossus bats (small, foliage-roosting species with specialized diets), which may in turn affect the reproductive success of plants pollinated by these species. Our study demonstrates how decade-long monitoring can reveal species-specific temporal patterns in pollinator visitation, emphasizing the need for tailored conservation plans. While the conservation status of most nectarivorous bats in the area is Least Concern, our results indicate that population studies in Southeast Asia are urgently needed for updated bat species conservation assessments.