bluuebunny/crossref_metadata_2025_split huggingface dataset:
Splenic cyst deroofing complicated with B lymphoma
Authors: De Quirós Mercedes Bernaldo , Jiménez-Romero Carlos , Suárez Antonio , Vazquez Pablo , Loinaz Carmelo , Justo Iago 
Published: March 2024

Abstract

Background: Splenic cysts are uncommon and very rarely malignant therefore their treatment isn’t standardised. In case of symptomatic cysts different surgical approaches have been suggested. Primary malignant lymphoma of the spleen comprises less than 1% of non-Hodgkin’s lymphomas. To our knowledge, only 203 cases of splenic large B-cell lymphoma (LBCL) have been reported to date and only 2 of them were fibrin-associated splenic cysts.
Case presentation: 27-year-old model with a 19x13cm splenic cyst without data of malignancy in the preliminary study and therefore treated with laparoscopic deroofing. After histological diagnosis of LBCL with a fibrin/EVB-associated splenic pseudocyst the patient received 4 cycles of Rituximab and a laparoscopic splenectomy was performed due to resurgence of the pseudocyst. No evidence of malignancy has been found in controls performed after the splenectomy.
Discussion and Conclusions: the value of tumour markers and radiology for diagnosis of splenic cysts is put into question.
Only 60 cases of Fibrin-associated LBCL (FA-LBCL) have been described in the literature therefore there are no treatment guidelines for them even though surgery together with systemic treatment has been the prevalent route with good results in most cases.
Agronomic and Crude Protein Content Performance of Desi and Kabuli chickpea (Cicer arietinum L.) varieties across locations in Ethiopia
Authors: Gebeyaw Mekonnen , Fikre Asnake , Abate Alemu , Setotaw Tesfahun Alemu 
Published: March 2024

Abstract

An experiment was carried out in Adet, Debre Zeit, and Fogera stations, with eight Desi and twelve Kabuli type chickpea varieties laid out in a randomized complete block design (RCBD) with three replications. Teketay and Geletu varieties of Desi type chickpea had the greatest combined mean grain yield values of 1803.6 kg/ha and 1608.9 kg/ha, respectively.While Dhera (1840.8 kg/ha), Hora (1818 kg/ha), and Koka (1727.7kg/ha) had the greatest mean grain yield values among the Kabuli type chickpea varieties. In Adet station, Teketay (1960 kg/ha) was top producer among Desi type chickpea varieties while Koka (1411.3 kg/ha) and Dhera (1176.7kg/ha) had the highest mean grain yields. The Desi type chickpea variety Eshete (2933.3Kg/ha) produced the greatest mean value of grain yield at DebreZeit station, followed by Teketay (2433.3Kg/ha) and Geletu (2100.0Kg/ha). Similarly, Hora (3433.3Kg/ha), Dhera (3333.3Kg/ha), and Ejere (3066.7Kg/ha) obtained the greatest mean value of grain yield in Kabuli type chickpea varieties. In general, Fogera station was poorer in performance. The Desi type chickpea variety Natoli produced the greatest mean value of grain at Fogera Station (1161.7kg/ha), followed by Dalota (1074.3 kg/ha) and Teketay (1017.3 kg/ha). The majority of Kabuli type chickpea varieties performed poorly at Fogera station, with Ejere recording the greatest mean grain yield (1028.33kg/ha), followed by Koka (1025 kg/ha), Habru (1015 kg/ha), and Dhera (1012.67 kg/ha).In context, farmers and other chickpea growers of similar Ethiopian agroecosystems can adopt the varieties that were suggested for both general and specific adaptation.
Study on the Effects of the National Volume-Based Procurement of Chemical Drugs on Chinese Patent Medicines: Lipid-Lowering Drugs as an Example
Authors: Yang Zhao , Han Xiao , Liang Pei , Zhao Xiaoting , Zhu Qiyun , Ye Hui , Jiang Bin 
Published: March 2024

Abstract
Background
China implemented National Volume-Based Procurement (NVBP) to reduce drug prices while also changing the structure of medication in medical institutions. However, the effects of NVBP on Chinese patent medicines are unknown.
Methods
In this study, we examine the effect of the policy on bid-winning chemical drugs (atorvastatin and rosuvastatin) on the availability and affordability of lipid-lowering Chinese patent medicines (Xuezhikang and Zhibitai). We also investigated changes in defined daily doses (DDDs) and expenditures across all levels of hospitals and discussed their underlying influencing factors.
Results
The unit prices of atorvastatin and rosuvastatin were cut by 25–96%, with minor fluctuations in the prices of Zhibitai and Xuezhikang. Following the policy's implementation, the average affordability of atorvastatin increased from 0.242 to 0.014, while that of rosuvastatin increased from 0.247 to 0.019. The DDDs for atorvastatin and rosuvastatin increased, while total expenditures decreased at all levels of hospitals. Both at the national level and in all levels of hospitals, the policy had no significant impact on Zhibitai and Xuezhikang's DDDs or expenditures.
Conclusions
The NVBP has demonstrated an initial cost-saving effect in the short term by including high-quality and widely used lipid-lowering drugs. The policy has a significant impact on lipid-lowering chemical drugs, whereas Chinese patent medicines was little affected. Overall, doctors have not reduced their use of Chinese patent medicines, and there is no obvious substitution relationship between the two, demonstrating the specificity of Chinese patent medicines in clinical use.
A novel strategy of infusion of ceftazidime-avibactam plus aztreonam for the treatment of infections due to OXA48 &amp; NDM producing carbapenem resistantKlebsiella pneumoniae: Time is of the essence
Authors: Soman Rajeev , Gandhi Aashna , Kedare Noopur , Joe Geethu , Patil Saiprasad , Pednekar Amullya , Barkate Hanmant 
Published: March 2024

Abstract
Purpose: Ceftazidime-avibactam (CAZ-AVI) along with aztreonam (ATM) is widely used off-label in clinical practice in India for OXA48 plus NDM producing carbapenem resistant Klebsiella pneumoniae (CR Kp). If the level of AVI is maintained at 2.5 mg/ml, it protects ATM from OXA48 and allows it to act against NDM producing CR Kp, for which the MIC to ATM has been found in a published report to be 2 mg/ml. Extrapolative considerations suggest that if CAZ-AVI is infused over 3 hours & ATM over the 2nd half, half an hour after starting the CAZ-AVI infusion, it may be possible to maintain levels of AVI above 2.5 mg/ml & ATM levels above 4 times the assumed MIC of 2 mg/ml, for more than 50% of the dosing interval. This may be a worthwhile strategy for both good efficacy & resistance suppression.
Methods: Plasma samples for levels of CAZ, AVI & ATM were collected at 1, 3, 5 h after infusing the drugs in the above-mentioned manner. Drug levels were measured at the Laboratori de Referència de Catalunya in Barcelona, Spain.
Results: In this pharmacokinetic proof-of-concept study in 5 consecutive adult patients infected with CR Kp, all levels of ATM at 5 h after beginning the infusion were at or above 20 mg/ml.
Conclusion: T > 4xMIC for 50% of the dosing interval was easily achieved in all the patients. This PK/PD index is higher than that needed for optimal killing & is considered as the PK/PD index for resistance suppression.
Wait-free Algorithms: the Burden of the Past
Authors: Bédin Denis , Lépine François , Mostéfaoui Achour , Perez Damien , Perrin Matthieu 
Published: March 2024

Abstract
Herlihy proved that compare-and-set (CAS) is universal in the classical computing system model composed of an a priori known number of processes.
For this, he proposed the first
universal construction capable of emulating any data structure with a sequential specification.
It has recently been proved that CAS is still universal in the infinite arrival
computing model, a model where any number of processes can be created on the fly.

This paper explores the complexity issues related to the wait-free CAS-based universal constructions.
We first prove that CAS does not allow to implement wait-free and linearizable visible objects in the infinite arrival model
with a space complexity bounded by the number of active processes.
We then show that this lower bound is tight, in the sense that this dependency can be made as low as desired
by proposing a wait-free and linearizable universal construction, using the CAS operation,
whose space complexity dependancy on the number of ever issued operations is defined by a parameter
that can be linked to any unbounded function.

This paper also proves that the lower bound obtained for CAS-based algorithms might be avoided by the use of other synchronization primitives.
As an example, we explore algorithms based on the memory-to-memory swap special instruction, that exchanges the content of two shared registers.
We propose a universal construction based on memory-to-memory swap whose complexity only depends on the contention, and we illustrate how compare-and-set
and memory-to-memory swap can be used jointly within a wait-free queue algorithm.
Conceptual design of a cryocooler and investigation of the effect of design parameters on cryocooler performance
Authors: Hamzeh Morteza , Kachabi Amirreza , Andayesh Mohammad , Fadaei Mohammad Heidar Khamsehei 
Published: March 2024

Abstract
Pulse tube cryocooler has low vibration and high reliability because of the lack of displacer in the cold area. This advantage cause development of these cryocoolers. In some applications such as MRI systems which need cryocoolers for cooling magnet, using them will improve the imaging quality.
In this article, the steps of designing a pulse tube cryocooler which is able to be installed in MRI systems will be introduced. As conceptual design is a vital section of any design project, this part has been totally studied; Necessary data has been gathered and developed in order to have best function in the pulse tube system. Preliminary design with help of two analyses (Phasor and Isotherm analysis) is introduced to designers and important parameters are obtained. Then investigation of the effect of some design parameters like valve timing, reservoir volume and pressure ratio using isothermal analysis has been done on cryocooler performance.
Huge endometrioma mimicking ovarian malignancy : a case report
Authors: Hsu Yu Chen , Hsu Keng-Fu 
Published: March 2024

Abstract
Background
Endometriosis is a very common disease, yet sometimes it is hard to be diagnosed. Typical symptoms include pelvic pain and infertility. However, it could present with a variety of symptoms depending on different type of endometriosis. There are also a variety of imaging findings indicative of endometriosis with varying sizes and locations. Huge ovarian mass accompanied with mass-effect symptoms was not usual in typical endometriosis, and may be considered as ovarian malignancy at initial diagnosis.
Case presentation
A middle-aged woman presented with dyspnea, lower leg edema, and abdominal dullness for 2-3 years. Laboratory exam showed severe anemia, severe hypokalemia, impaired renal function, and metabolic acidosis. Abdominal sonography and computed tomography (CT) showed huge pelvic mass 35x33x28cm with solid part. Exploratory laparotomy revealed right ovarian endometrioma and endometriosis of sigmoid colon. After operation, she had much less dyspnea and abdominal dullness, while renal function was only partially improved with bilateral ureteral stents remained in place.
Conclusion
We presented a case report of huge endometrioma mimicking ovarian malignancy. The atypical symptoms and image findings were uncommon for endometriosis. We thus shared this case for help further differential diagnosis of huge pelvic mass.
Exploring the Structural Diversity of Novel 3-Substituted Coumarins as Potent Inhibitors of Tumor-Associated Carbonic Anhydrases: Expanding the Pharmacological Space for Anticancer Drug Discovery
Authors: Matar Islam K. , Al-Hussain Sami A. , Muhammad Zeinab A. , Al-Ali Maha , Zaki Magdi E. A. , Gomha Sobhi M. , El-khouly Ahmed S. 
Published: March 2024

Abstract
Background
Innovations in cancer chemotherapy continue to occupy the priority list of demands to ensure our health security. The vast chemical space provides a plethora of anticancer discovery opportunities, however, limited by the boundaries of synthetic feasibility.
Objective
Expand the established pharmacological space of tumor-associated carbonic anhydrases by exploring the synthetically feasible chemical space of 3-substituted coumarins.
Method
A series of 52 novel 3-substituted coumarins were randomly sketched by our team of synthetic chemists with priority given to synthetic feasibility. The pharmacological potentials of the novel coumarin series were computationally estimated using a machine-learning approach exploiting both chemical and statistical inference. 17 members of the novel series were predicted to possess cytotoxic activity against HeLa cells by interfering with the tumor-associated carbonic anhydrases IX and XII. Those 17 compounds were synthesized and biologically tested against HeLa cells, subsequently; the 3 most potent compounds were assayed against carbonic anhydrases I, II, IX, and XII employing Acetazolamide as a reference. The molecular binding mechanism of those 3 chosen compounds with the four enzyme isoforms was studied using molecular docking simulation.
Result
Most of the compounds exhibited competent inhibitory activity against HeLa cells. The carbonic anhydrase inhibition results unveiled the powerful but non-selective nature of those suicide inhibitors.
Conclusion
Novel 3-substituted coumarins have been dispatched to join the pharmacological space of tumor-associated carbonic anhydrases’ suicide inhibitors.
Deciphering the Immunotoxicity of Titanium Dioxide Nanoparticles (E171) in Mouse Leukocytes through Single-Cell RNA Sequencing
Authors: Perumalsamy Haribalan , Xiao Xiao , Han Hyoung-Yun , Oh Jung-Hwa , Yoon Seokjoo , Heo Min Beom , Lee Tae Geol , Kim Hyun-Yi , Yoon Tae Hyun 
Published: March 2024

Abstract

The cellular and immunological responses in the immune system after exposure to TiO2 NPs/E171 are poorly understood. Therefore, comprehensive single-cell RNA-seq (scRNA-seq) analysis was used to explore the unique heterogeneous response upon TiO2 NPs/E171 treatment in Sprague-Dawley rats. Firstly, granulocyte G1 activated innate immune response through the upregulation of genes involved in pro-inflammatory cytokine mediated cytotoxicity. Whereas NK cells resulted in heterogeneity role depending on the subsets where NK1 significantly inhibited cytotoxicity, whereas NK2 and NK3 subsets activated pro-B cell population & inhibited T cell mediated cytotoxicity respectively. While NKT_1 activated innate inflammatory responses which was confirmed by cytotoxic CD8 + T killer cell suppression. Similarly, NKT_2 cells promote inflammatory response by releasing lytic granules and MHC-I complex inhibition to arrest cytotoxic T killer cell responses. Conversely, NKT_3 suppressed inflammatory response by release of anti-inflammatory cytokines suggesting the functional heterogeneity of NKT subset. The formation of MHC-I or MHC-II complexes with T-cell subsets resulted in neither B and T cell dysfunction nor cytotoxic T killer cell inhibition suppressing adaptive immune response. This study not only masks the drawbacks of utilizing homogeneous immune cell types, but also provides a full understanding of high-dimensional heterogeneous immunological response at the single cell level.
Improvement of nucleotide content of Cordyceps tenuipes by Schisandra chinensis: fermentation process optimization and application prospects
Authors: Li Anni , Zhu Qiang , Li Yuting , Yang Lu , Chen Zhihao , Zhou Xiang , Xia Yanqiu 
Published: March 2024

Abstract

Nucleotides are important components and the main indicators for judging Cordyceps quality. To increase the nucleoside content of Cordyceps tenuipes for enhancing the efficacy activity. In this paper, the mixed fermentation process of Schisandra chinensis and C. tenuipes was systematically studied, and it was proposed that the fermentation products aqueous extract (S-ZAE) had antioxidant activity and anti-AChE ability. Herein, the results of a single factor showed that S. chinensis, yeast extract, inoculum amount, and pH had significant effects on nucleotide synthesis, and these four factors were used as the factor of response surface optimization. The results of response surface optimization were 3% glucose, 0.25% KH2PO4, 2.1% yeast extract, and S. chinensis 0.49% (m/v), the optimal fermentation conditions were 25℃, inoculum 5.8% (v/v), pH 3.8, 6 d. The yield of total nucleotides in the scale-up culture was 0.64 ± 0.027 mg/mL, which was 10.67 times that before optimization, and S-ZAE has good antioxidant and anti-AChE activities. This fermentation method has the advantage of industrialization, and its fermentation products have the potential to become good functional foods or natural therapeutic agents.
Poly-CAM: High resolution Class Activation Map for Convolutional Neural Networks
Authors: Englebert Alexandre , Cornu Olivier , De Vleeschouwer Christophe 
Published: March 2024

Abstract

The demand for explainable AI continues to rise alongside advancements in deep learning technology. Existing methods such as convolutional neural networks often struggle to accurately pinpoint the image features justifying a network's prediction due to low-resolution saliency maps (e.g., CAM), smooth visualizations from perturbation-based techniques, or numerous isolated peaky spots in gradient-based approaches. In response, our work seeks to merge information from earlier and later layers within the network to create high-resolution class activation maps that not only maintain a level of competitiveness with previous art in terms of insertion-deletion faithfulness metrics but also significantly surpass it regarding the precision of localizing class-specific features.
Deep Hunting Social Optimization Algorithm Enabled Deep Neuro Fuzzy Network for Facial Expression Recognition
Authors: Komala K , Jayadevappa D , AP Manjunatha Manjunatha 
Published: March 2024

Abstract
Recently, a number of researchers have been able to identify human emotions from facial expressions. Realistically speaking, emotion communication is a transient and multimodal process, which makes identifying human emotions difficult. This paper proposes an effective model for multimodal facial expression recognition using the Deer Hunting Social Optimization Algorithm (DHSOA) based Deep Neuro Fuzzy Network (DNFN) in order to overcome such problems in the existing models and achieve outstanding performance in the field of human facial expression recognition. In this work, input video and input electroencephalogram (EEG) signals are considered for additional processing. The feature selection stage uses DHSOA to select appropriate features from input video and EEG signal phases. In contrast, the suggested DHSOA-based DNFN for facial video has a maximum accuracy of 0.910, a precision of 0.899, and a recall of 0.900.
Mechanisms of Secondary Biogenic Coalbed Methane Formation in Bituminous Coal Seams: A Joint Experimental and Multi-Omics Study
Authors: Zhang Xun , Liu Bingjun , Xue Sheng , Chen Jian , Zheng Chunshan , Yang Yang , Zhou Tianyao , Wang Junyu , Zhang Jingbei 
Published: March 2024

Abstract

Coal seam microbes, as endogenous drivers of secondary biogenic gas production in coal seams, might be related to methane production in coal seams. In this study, we carried out anaerobic indoor culture experiments of microorganisms from three different depths of bituminous coal seams in Huainan mining area, and revealed the secondary biogas generation mechanism of bituminous coal seams by using the combined analysis of macro-genome and metabolism multi-omics. The results showed that the cumulative mass molar concentrations (Molality) of biomethane production increased with the increase of the coal seam depth in two consecutive cycles; At the genus level, there were significant differences in the bacterial and archaeal community structures corresponding to the three coal seams 1#, 6#, and 9#, with correlations of R bacterial = 0.368 and R archaeal = 0.463, respectively; Vad and Vi of coal were significantly correlated with differences in genus-level composition of bacteria and archaea; the largest difference in functional genes related to the methanogenic metabolic pathway was observed before and after incubation of coal bed microorganisms, with an average positive growth of 42%; meanwhile, a total of 11 classes of carbon metabolism homologues closely related to methanogenesis were detected in the liquid metabolites of coal bed microbes after 60 days of incubation. Finally, the fatty acid, amino acid and carbohydrate synergistic methanogenic metabolic pathway was reconstructed based on KEGG database; the expression level of mcrA gene within the metabolic pathway of the 1# deep coal sample was significantly higher than that of the other two groups (p < 0.05 for significance), and the efficient expression of this functional gene at the front end of the methanogenic pathway facilitates the conversion of bituminous coal organic matter to methane. Therefore, coal quality (Vad) is likely to be one of the key factors causing diversity in microbial community composition and metabolic function differences in different coal seams.
Trajectories of long-term exposure to PCB153 and Benzo[a]pyrene (BaP) air pollution and risk of breast cancer
Authors: Desnavailles Pauline , Praud Delphine , Provost Blandine Le , Kobayashi Hidetaka , Deygas Floriane , Amadou Amina , Coudon Thomas , Grassot Lény , Faure Elodie , Couvidat Florian , Severi Gianluca , Mancini Francesca Romana , Fervers Béatrice , Proust-Lima Cécile , Leffondré Karen 
Published: March 2024

Abstract

Background: While genetic, hormonal, and lifestyle factors partially elucidate the incidence of breast cancer, emerging research has underscored the potential contribution of air pollution. Polychlorinated biphenyls (PCBs) and benzo[a]pyrene (BaP), are of particular concern due to endocrine-disrupting properties, and accumulation in various environmental matrices and human adipose tissue owing to poor biodegradability.
Objective: To identify distinct lifetime trajectories of exposure to PCB153 and BaP, and estimate their associations with breast cancer risk.
Methods: We used data from the XENAIR case-control study, nested within the ongoing prospective French E3N cohort which enrolled 98,995 women aged 40-65 years in 1990-1991. Cases were incident cases of primary invasive breast cancer diagnosed from cohort entry to 2011. Controls were randomly selected by incidence density sampling, and individually matched to cases on delay since cohort entry, and date, age, department of residence, and menopausal status at cohort entry. Annual mean outdoor PCB153 and BaP concentrations at residential addresses from 1990 to 2011 were estimated using the CHIMERE chemistry-transport model. Latent class mixed models were used to identify profiles of exposure trajectories from cohort entry to the index date, and conditional logistic regression to estimate their association with the odds of breast cancer.
Results: 5058 cases and 5059 controls contributed to the analysis. Five profiles of trajectories of PCB153 exposure were identified. The class with the highest PCB153 concentrations had a 69% increased odds of breast cancer compared to the class with the lowest concentrations (95% CI 1.08, 2.64), after adjustment for education and matching factors. We found no association between identified BaP trajectories and breast cancer.
Conclusions: Our results support an association between long term exposure to PCB153 and the risk of breast cancer, and encourage further studies to account for lifetime exposure to persistent organic pollutants.