bluuebunny/crossref_metadata_2025_split huggingface dataset:
SLC24A-mediated calcium exchange as an indispensable component of the diatom cell density-driven signaling pathway
Authors: Liu Xuehua , Zuo Zhicheng , Xie Xiujun , Gao Shan , Wu Songcui , Gu Wenhui , Wang Guangce 
Published: March 2024

Abstract
Diatom bloom is characterized by a rapid increase of population density. Perception of population density and physiological responses can significantly influence their survival strategies, subsequently impacting bloom fate. The population density itself can serve as a signal, which is perceived through chemical signals or chlorophyll fluorescence signals triggered by high cell density, and their intracellular signaling mechanisms remain to be elucidated. In this study, we focused on the model diatom, Phaeodactylum tricornutum, and designed an orthogonal experiment involving varying cell densities and light conditions, to stimulate the release of chemical signals and light-induced chlorophyll fluorescence signals. Utilizing RNA-Seq and Weighted Gene Co-expression Network Analysis, we identified four gene clusters displaying density-dependent expression patterns. Within these, a potential hub gene, PtSLC24A, encoding a Na+/Ca2+ exchanger, was identified. Based on molecular genetics, cellular physiology, computational structural biology, and in situ oceanic data, we propose a potential intracellular signaling mechanism related to cell density in marine diatoms using Ca2+: upon sensing population density signals mediated by chemical cues, the membrane-bound PtSLC24A facilitates the efflux of Ca2+ to maintain specific intracellular calcium levels, allowing the transduction of intracellular density signals, subsequently regulating physiological responses, including cell apoptosis, ultimately affecting algal blooms fate. These findings shed light on the calcium-mediated intracellular signaling mechanism of marine diatoms to changing population densities, and enhances our understanding of diatom bloom dynamics and their ecological implications.
Memory-Political Deterrence: Shielding Collective Memory and Ontological Security through Dissuasion
Authors: Gustafsson Karl , Mälksoo Maria 
Published: March 2024

Abstract
Traditionally used within the context of hard military power in interstate relations, the concept of deterrence has been progressively extended to non-state actors and new issue areas. While scholarship on the social aspects of deterrence has expanded our understanding of this core international security practice, the focus of existing research has largely remained on physical security. This article argues that there is a phenomenon in international politics that can be called memory-political deterrence. Memory-political deterrence refers to the ways in which states seek to dissuade other political actors from taking actions that threaten the collective memory narratives that underpin the ontological security of the deterring actor. Memory-political deterrence works, for example, through political rhetoric, declarations, diplomatic insults, commemorative practices, and punitive memory laws. We illustrate the article’s arguments through empirical examples from Russia’s and China’s recent memory-political deterrence efforts toward Ukraine and Japan, respectively. In doing so, we elucidate the ways in which memory politics is intertwined with geopolitics, underpinning wider world-ordering aspirations.
A data-driven approach to choosing privacy parameters for clinical trial data sharing under differential privacy
Authors: Chen Henian , Pang Jinyong , Zhao Yayi , Giddens Spencer , Ficek Joseph , Valente Matthew J , Cao Biwei , Daley Ellen 
Published: March 2024

AbstractObjectivesClinical trial data sharing is crucial for promoting transparency and collaborative efforts in medical research. Differential privacy (DP) is a formal statistical technique for anonymizing shared data that balances privacy of individual records and accuracy of replicated results through a “privacy budget” parameter, ε. DP is considered the state of the art in privacy-protected data publication and is underutilized in clinical trial data sharing. This study is focused on identifying ε values for the sharing of clinical trial data.Materials and MethodsWe analyzed 2 clinical trial datasets with privacy budget ε ranging from 0.01 to 10. Smaller values of ε entail adding greater amounts of random noise, with better privacy as a result. Comparison of rates, odds ratios, means, and mean differences between the original clinical trial datasets and the empirical distribution of the DP estimator was performed.ResultsThe DP rate closely approximated the original rate of 6.5% when ε &gt; 1. The DP odds ratio closely aligned with the original odds ratio of 0.689 when ε ≥ 3. The DP mean closely approximated the original mean of 164.64 when ε ≥ 1. As ε increased to 5, both the minimum and maximum DP means converged toward the original mean.DiscussionThere is no consensus on how to choose the privacy budget ε. The definition of DP does not specify the required level of privacy, and there is no established formula for determining ε.ConclusionOur findings suggest that the application of DP holds promise in the context of sharing clinical trial data.
Quality of life of caregivers at the end of their child’s pediatric cancer treatment: cancer-specific worry and material hardship
Authors: Galtieri Liana R , Perez Megan N , Barakat Lamia P 
Published: March 2024

Abstract

Objective
Emerging research suggests that completion of pediatric cancer treatment can be challenging for caregivers given shifting roles and responsibilities. Lower caregiver quality of life (QOL) has been associated with cancer-related variables, higher cancer caregiving strain, and more household material hardship during pediatric cancer treatment. Caregiver QOL at the end of treatment has not been fully investigated but has implications for child and family well-being. Using a psycho-oncology framework, this study aimed to understand the cumulative burden of household material hardship and cancer-related factors on caregiver QOL at the end of treatment.

Methods
Caregivers (N = 143) of children (Mage=10.51 years) within 1 year of ending active cancer treatment completed self-report questionnaires assessing their QOL, cancer-specific worry, and material hardship (e.g., housing, insurance). Total months of active cancer treatment were extracted from the medical record. Hierarchical linear regression was used to test the relative effects of length of treatment, material hardship, and cancer-specific worry on caregiver QOL.

Results
Cancer-specific worry was significantly associated with and accounted for significant variance in caregiver QOL, above and beyond the length of treatment and material hardship. Caregivers who endorsed more cancer-specific worry had poorer QOL. Material hardship was also significantly associated with caregivers’ QOL, but length of treatment was not.

Conclusions
Caregivers with sufficient resources and less worry about cancer have higher QOL. Findings highlight the importance of end-of-treatment screening of caregivers’ subjective cancer-specific worry in addition to material hardship, irrespective of their cancer-related stressors, for ongoing psychosocial support.
Successful treatment of ulcerated hemangioma with diversion colostomy in a neonate with LUMBAR syndrome
Authors: Shah Ananya , Tollefson Megha , Ahn Edward S , Gibreel Waleed , Polites Stephanie 
Published: March 2024

Abstract
We present the case of a 3-week-old girl with LUMBAR syndrome, a rare condition involving segmental infantile hemangiomas (IH) in the lumbosacral region, myelopathy, and other congenital anomalies. The patient developed severe ulceration of a left buttock IH. Treatment included broad-spectrum antibiotics, debridement, and a laparoscopic temporary colostomy. Propranolol therapy, wound care, and fecal diversion led to successful healing of the ulceration. The report highlights the challenges of ulcerated IH in the perineal area due to exposure to urine and stool. The comprehensive approach resulted in positive outcomes, including the successful surgical treatment of spinal dysraphism, successful colostomy reversal, and developmental progress. This case contributes insight into the surgical management of severe perianal ulcerated IH associated with LUMBAR syndrome, highlighting the importance of a tailored surgical approach with a multidisciplinary framework.
Laparoscopic light source skin burn
Authors: Hamdi Jamal T 
Published: March 2024

Abstract
Skin burn injury from light cables is a rare complication of laparoscopic surgery, but it can be severe and distressing for both the patient and the surgeon. A case report of skin burns due to laparoscopic light source is presented in this article, followed by an experimental trial to confirm the findings, and review of literature. The light source is usually connected to the camera to give adequate light inside the abdominal cavity for visualization of the internal organs, and hence, safe surgery. The light source should deliver cool light to prevent any burn from heat to skin or internal organs, but in fact, it is not usually cool and can reach high temperatures. Precautions and recommendations to avoid skin burns due to the light source are included. Surgeons should be aware of burns from light sources in laparoscopic surgery and take precautions to prevent them.
Recurrent vaginal evisceration of abdominal contents with subsequent resection of necrotic omentum in a 35-year-old woman
Authors: Horton Crista E , Baghdadi Ahmad , Putnick Jennine , Gravely Trevor 
Published: March 2024

Abstract
Vaginal evisceration is a rare surgical emergency in which intra-abdominal contents protrude through a dehisced vaginal cuff, which can lead to bowel ischemia and abdominal sepsis. This condition occurs due to vaginal cuff weakness secondary to prior surgeries or trauma. Recurrence after repair is rare and few cases have been documented. Here we present a young woman with multiple prior gynecologic surgeries who presented with eviscerated small bowel and omentum from her vagina five months following surgical treatment of a previous vaginal evisceration. Via a transabdominal surgical approach, general surgery and gynecology teams reduced the intra-abdominal contents, resected a pedicle of necrotic omentum, suture repaired the vaginal cuff, and placed a dehydrated placental allograft. This extremely rare case of recurrent vaginal evisceration demonstrates the importance of taking appropriate preventative surgical measures, maintaining a healthy level of suspicion for recurrence, knowing potential complications, and educating patients to prevent recurrent vaginal evisceration.
Superoxide signalling and antioxidant processing in the plant nucleus
Authors: Karpinska Barbara , Foyer Christine H 
Published: March 2024

Abstract
The superoxide anion radical (O2·−) is a one-electron reduction product of molecular oxygen. Compared with other forms of reactive oxygen species (ROS), superoxide has limited reactivity. Nevertheless, superoxide reacts with nitric oxide, ascorbate, and the iron moieties of [Fe–S] cluster-containing proteins. Superoxide has largely been neglected as a signalling molecule in the plant literature in favour of the most stable ROS form, hydrogen peroxide. However, superoxide can accumulate in plant cells, particularly in meristems, where superoxide dismutase activity and ascorbate accumulation are limited (or absent), or when superoxide is generated within the lipid environment of membranes. Moreover, oxidation of the nucleus in response to environmental stresses is a widespread phenomenon. Superoxide is generated in many intracellular compartments including mitochondria, chloroplasts, and on the apoplastic/cell wall face of the plasma membrane. However, nuclear superoxide production and functions remain poorly documented in plants. Accumulating evidence suggests that the nuclear pools of antioxidants such as glutathione are discrete and separate from the cytosolic pools, allowing compartment-specific signalling in the nucleus. We consider the potential mechanisms of superoxide generation and targets in the nucleus, together with the importance of antioxidant processing in regulating superoxide signalling.
Discovery of a new blue large-amplitude pulsator in the SkyMapper DR2: SMSS J184506.82−300804.7
Authors: Chang Seo-Won , Wolf Christian , Onken Christopher A , Bessell Michael S 
Published: March 2024

ABSTRACT
We report the discovery of a new Blue Large-Amplitude Pulsator (BLAP), SMSS J184506−300804 (SMSS-BLAP-1) in Data Release 2 of the SkyMapper Southern Sky Survey. We conduct high-cadence photometric observations in the u band to confirm a periodic modulation of the light curve. SMSS-BLAP-1 has a ∼19-min pulsation period with an amplitude of 0.2 mag in u band, and is similar to the classical BLAPs found by OGLE. From spectroscopic observations with the Wide-Field Spectrograph on the Australian National University 2.3m telescope, we confirm it as a low-gravity BLAP: best-fitting parameters from the non-LTE tlusty model are estimated as Teff = 29 020$^{+193}_{-34}$ K, logg = 4.661$^{+0.008}_{-0.143}$ (cm s−2), and logn(He)/n(H) = −2.722$^{+0.057}_{-0.074}$ dex. However, our BLAP exhibits a very He-deficient atmosphere compared to both low- and high-gravity BLAPs, which have logn(He)/n(H) in the range −0.41∼−2.4.
Searching for globular clusters in the inner halo of the Circinus galaxy
Authors: Obasi C , Gómez M , Minniti D , Baravalle L D , Alonso M V , Okere B I 
Published: March 2024

ABSTRACT
In this study, we search for globular clusters (GCs) in the inner halo of the Circinus galaxy using a combination of observational data. Our data set includes observations from the VISTA Variables in the Vía Láctea Extended Survey (VVVX), optical data from Gaia Release 3 (DR3), and observations from the Dark Energy Camera (DECam). These multiple data sources provide a comprehensive basis for our analysis. Our search was concentrated within a 50 kpc radius from the centre, leading to the identification of 93 sources that met our established criteria. To ensure the reliability of our findings, we conducted multiple examinations for sample contamination. These examinations incorporated tests based on Gaia Astrometric Excess Noise (AEN), the blue photometer/red photometer (BRexcess) excess factor, as well as comparisons with stellar population models. This analysis confidently classified 41 sources as genuine GCs, as they successfully passed both the 3σ Gaia AEN and BRexcess tests. We used the ISHAPE program to determine the structural parameters (half-light radii) of the GC candidates, with a peak effective radius of 4 ± 0.5 pc. The catalogue mainly consists of bright GCs. Relationships between colour, size, and distance were found in the GC candidates, alongside confirmation of bi-modality in colour distributions.
Short and long time-scales variability of the H α double-peaked profile of Pictor A
Authors: Marsango Daniel , Schimoia Jáderson S , Rembold Sandro B , Storchi-Bergmann Thaisa , Nemmen Rodrigo S , Couto Guilherme S , Souza-Oliveira Gabriel Luan , Costa-Souza José Henrique 
Published: March 2024

ABSTRACT
We present the results of the analysis of 18 optical spectra covering the H α profile region of the active nucleus of the galaxy Pictor A obtained in different epochs along 12 yr. With these data, we model the variability of the double-peaked H α emission of the nucleus of this galaxy. We find small variations in the integrated flux of the broad component of H α, occurring on short time-scales, of the order of 40 d. In addition, significant variations in the relative intensities of the red and blue sides of the broad profile occur on time-scales of years. In order to explain the observations, we propose a scenario in which the double-peak profile is produced by a flattened distribution of clouds surrounding the accretion disc with Keplerian and relativistic orbits, inclined in relation to the sky plane, and with axially asymmetric surface emissivity with the radius of maximum emissivity. We find that, for the theoretical time-scales of the disc-like BLR to conform the time-scales of variation observed for the double-peak profile, it is necessary for the gas in the disc to orbit a SMBH with a mass of M• $\approx \, 2\times$ $10^{8}\, \mbox{M}_\odot$. In this scenario, the physical extension of the line-emitting region extends by 6–48 light-days from the SMBH.
The effects of non-linearity on the growth rate constraint from velocity correlation functions
Authors: Tonegawa Motonari , Appleby Stephen , Park Changbom , Hong Sungwook E , Kim Juhan 
Published: March 2024

ABSTRACT
The two-point statistics of the cosmic velocity field, measured from galaxy peculiar velocity (PV) surveys, can be used as a dynamical probe to constrain the growth rate of large-scale structures in the Universe. Most works use the statistics on scales down to a few tens of Megaparsecs, while using a theoretical template based on the linear theory. In addition, while the cosmic velocity is volume-weighted, the observable line-of-sight velocity two-point correlation is density-weighted, as sampled by galaxies, and therefore the density–velocity correlation term also contributes, which has often been neglected. These effects are fourth order in powers of the linear density fluctuation $\delta _{\rm L}^4$, compared to $\delta _{\rm L}^2$ of the linear velocity correlation function, and have the opposite sign. We present these terms up to $\delta _{\rm L}^4$ in real space based on the standard perturbation theory, and investigate the effect of non-linearity and the density–velocity contribution on the inferred growth rate fσ8, using N-body simulations. We find that for a next-generation PV survey of volume $\sim {\cal O}(500 \, h^{-1} \, {\rm Mpc})^3$, these effects amount to a shift of fσ8 by ∼10 per cent and is comparable to the forecasted statistical error when the minimum scale used for parameter estimation is $r_{\rm min} = 20 \, h^{-1} \, {\rm Mpc}$.
The dynamics of accretion flows near to the innermost stable circular orbit
Authors: Mummery Andrew , Mori Francesco , Balbus Steven 
Published: March 2024

ABSTRACT
Accretion flows are fundamentally turbulent systems, yet are classically modelled with viscous theories only valid on length scales significantly greater than the typical size of turbulent eddies in the flow. We demonstrate that, while this will be a reasonable bulk description of the flow at large radii, this must break down as the flow approaches absorbing boundaries, such as the innermost stable circular orbit (ISCO) of a black hole disc. This is because in a turbulent flow large velocity fluctuations can carry a fluid element over the ISCO from a finite distance away, from which it will not return, a process without analogy in conventional models. This introduces a non-zero directional bias into the velocity fluctuations in the near-ISCO disc. By studying reduced random walk problems, we derive a number of implications of the presence of an absorbing boundary in an accretion context. In particular, we show that the average velocity with which a typical fluid element crosses the ISCO is much larger than is assumed in traditional theories. This enhanced velocity modifies the thermodynamic properties of black hole accretion flows on both sides of the ISCO. In particular, thermodynamic quantities for larger ISCO stresses no longer display pronounced cusps at the ISCO in this new formalism, a result with relevance for a number of observational probes of the intra-ISCO region. Finally, we demonstrate that these extended models reproduce the trans-ISCO behaviour observed in GRMHD simulations of thin discs.
The double-peaked type I X-ray bursts with different mass accretion rate and fuel composition
Authors: Song Liyu , Liu Helei , Zhu Chunhua , Zhen Guoqing , Lü Guoliang , Xu Renxin 
Published: March 2024

ABSTRACT
Using the mesa (Modules for Experiments in Stellar Astrophysics) code, we have carried out a detailed survey of the available parameter space for the double-peaked type I X-ray bursts. We find that the double-peaked structure appears at mass accretion rate $\dot{M}$ in the range of $\sim (4-8)\times 10^{-10}\, {\rm M}_{\odot }\,{\rm yr}^{-1}$ when metallicity Z = 0.01, while in the range of $\sim (4-8)\times 10^{-9}\, {\rm M}_{\odot }\,\rm {yr}^{-1}$ when Z = 0.05. Calculations of the metallicity impact suggest that the double peaks will disappear when Z ≲ 0.005 for $\dot{M}=5\times 10^{-10}\, {\rm M}_{\odot }\,\rm {yr}^{-1}$ and Z ≲ 0.04 for $\dot{M}=5\times 10^{-9}\, {\rm M}_{\odot }\,\rm {yr}^{-1}$. Besides, the impacts of base heating Qb, as well as nuclear reaction waiting points: $^{22}\rm {Mg}$, $^{26}\rm {Si}$, $^{30}\rm {S}$, $^{34}\rm {Ar}$, 56Ni, $^{60}\rm Zn$, $^{64}\rm {Ge}$, $^{68}\rm {Se}$, and $^{72}\rm {Kr}$ have been explored. The luminosity of the two peaks decreases as Qb increases. 68Se(p, γ)69Br is the most sensitive reaction, the double peaks disappear assuming that 56Ni(p, γ)57Cu, and 64Ge(p, γ)65As reaction rates have been underestimated by a factor of 100 and the 22Mg(α, p)25Al reaction rate has been overestimated by a factor of 100, which indicates that 22Mg, 56Ni, 64Ge, and 68Se are possibly the most important nuclear waiting points impedance in the thermonuclear reaction flow to explain the double-peaked bursts. Comparisons to the double-peaked bursts from 4U 1636−53 and 4U 1730−22 suggest that the nuclear origins of double-peaked type I X-ray bursts are difficult to explain the observed larger peak times ($t_{\rm p,1}\gtrsim 4\, {\rm s}$, $t_{\rm p,2}\gtrsim 8\, {\rm s}$) and smaller peak ratio (r1, 2 ≲ 0.5). The composition of ashes from double-peaked bursts is very different from the single-peaked bursts especially for the heavier p-nuclei.
A.C.I.D – an improved LSD technique for accurate line profile retrieval
Authors: Dolan Lucy S , de Mooij Ernst J W , Watson Christopher A , Jackson David G 
Published: March 2024

ABSTRACT
Stellar activity and planetary effects induce radial velocity (RV) offsets and cause temporal distortions in the shape of the stellar line profile. Hence, accurately probing the stellar line profile offers a wealth of information on both the star itself and any orbiting planets. Typically, cross-correlation functions (CCFs) are used as a proxy for the stellar line profile. The shape of CCFs, however, can be distorted by line blending and aliasing limiting the stellar and planetary physics that can be probed from them. Least-squares deconvolution (LSD) offers an alternative that directly fits the mean line profile of the spectrum to produce a high-precision profile. In this paper, we introduce our novel method ACID (Accurate Continuum fItting and Deconvolution) that builds on LSD techniques by simultaneously fitting the spectral continuum and line profile as well as performing LSD in effective optical depth. Tests on model data revealed ACID can accurately identify and correct the spectral continuum to retrieve an injected line profile. ACID was also applied to archival High Accuracy Radial-velocity Planet Searcher (HARPS) data obtained during the transit of HD189733b. The application of the Reloaded Rossiter–McLaughlin technique to both ACID profiles and HARPS CCFs shows ACID residual profiles improved the out-of-line root mean square (RMS) by over 5 per cent compared to CCFs. Furthermore, ACID profiles are shown to exhibit a Voigt profile shape that better describes the expected profile shape of the stellar line profile. This improved representation shows that ACID better preserves the stellar and planetary physics encoded in the stellar line profile shape for slow rotating stars.