bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early childhood neurodevelopmental milestones in children with allergic diseases: the Japan Environment and Children’s Study (JECS)
Authors: Nagata Abir , Onishi Kazunari , Masumoto Toshio , Nakagawa Takatoshi , Ishitsuka Kazue , Kurozawa Youichi 
Published: March 2024

AbstractThis study investigated the potential link between early childhood allergic diseases and neurodevelopmental milestone attainment during the first 3 years of life. Utilizing data from a large-scale prospective birth cohort study in Japan, encompassing 87,986 children, we examined physician-diagnosed and caregiver-reported allergic conditions, including atopic dermatitis (AD), asthma, and food allergy (FA). Neurodevelopmental milestones were assessed using the Ages and Stages Questionnaires at 1, 1.5, 2, 2.5, and 3 years of age. Stabilized inverse probability-weighted generalized estimating equation models were employed to estimate odds ratios (ORs). Our analysis revealed no significant association of AD and asthma with delay in communication, gross motor, fine motor, problem-solving, and personal-social skills during the initial 3 years of life. However, children with FA showed an increased likelihood of experiencing gross motor delay compared with that shown by those without FA (weighted adjusted OR: 1.14). Despite this, no significant association of FA with other developmental domains was observed. Early childhood allergies may not influence neurodevelopmental delays. However, there is a potential association between FA and delays, specifically in gross motor skills, that warrants routine developmental monitoring and additional investigations.
Research on rockburst prevention systems based on the attenuation law of coal and rock vibration wave energy
Authors: Rong Hai , Wang Zijian , Konicek Petr , Pan Liting , Tang Guoshui , Kajzar Vlastimil , Wang Yadi 
Published: March 2024

AbstractDuring the coal and rock mass fracture process, elastic properties are released and vibration waves are radiated outward. The energy attenuation characteristics of these waves can describe the cumulative damage and elastic energy accumulation of the mass. To investigate coal and rock mass failure characteristics and energy attenuation rules during rockburst, numerical simulation and laboratory testing were utilized to study the energy transfer laws under various parameters. Six variables, including elastic modulus, Poisson’s ratio, bulk density, cohesion, internal friction angle, and void ratio, were selected to simulate the rockburst energy release process under different parameter combinations by adding surface pressure to the model. The coal and rock mass energy attenuation coefficient was obtained by fitting the node energy straight line using the least squares method. The six variables’ influence on vibration wave energy transfer was obtained using analytic hierarchy process program written in MATLAB, and a comprehensive calculation formula was proposed. Using the energy attenuation coefficient, the rock layer energy diffusion distance was calculated and compared with the roof collapse rock layer step distance, resulting in the roof rock layer cutting distance determination. By roof rock strata precutting, rockburst occurrence can be prevented, ensuring safe and efficient coal mine production.
Correlates of sexual function in women with acute lumbar disc herniation in Iran: a cross-sectional study
Authors: Moradi Zahra , Shahali Shadab , Ahmadi Fazlollah , Montazeri Ali 
Published: March 2024

AbstractEvidence suggests that lumbar disc herniation (LDH) influences sexual function to a great deal. However, most existing studies have been conducted on men. Thus, the current study aimed to assess sexual function and its correlates in women with acute LDH. This descriptive cross-sectional study was conducted on 350 women of reproductive age with acute LDH in Fasa, Iran in 2023. The mean score of female sexual function was 21.33 (3.38). Almost 80% of women had sexual dysfunction. Women scored lower on sexual desire and the higher on lubrication. As the severity of LDH increased, arousal, lubrication and sexual pain score decreased and low back pain (LBP) score increased (p < 0.05). The number of sexual activities after disc herniation was significantly lower in the women with sexual dysfunction (p < 0.001). Regression analysis showed a significant association between sexual dysfunction and LBP intensity (OR = 1.13, CI 1.02–1.26, p = 0.01) and lumbar disc herniation intensity (OR = 2.22, CI 1.07–4.62, p = 0.03). Lumbar disc herniation (LDH) may significantly affect women's sexual function. Severity of low back pain and severity of lumbar disc herniation were found to be risk factors for sexual dysfunction in this population.
Binary and ternary logic-in-memory using nanosheet feedback field-effect transistors with triple-gated structure
Authors: Han Jongseong , Son Jaemin , Ryu Seungho , Cho Kyoungah , Kim Sangsig 
Published: March 2024

AbstractIn this study, we demonstrate binary and ternary logic-in-memory (LIM) operations of inverters and NAND and NOR gates comprising nanosheet (NS) feedback field-effect transistors (FBFETs) with a triple-gated structure. The NS FBFETs are reconfigured in p- or n-channel modes depending on the polarity of the gate bias voltage and exhibit steep switching characteristics with an extremely low subthreshold swing of 1.08 mV dec–1and a high ON/OFF current ratio of approximately 107. Logic circuits consisting of NS FBFETs perform binary and ternary logic operations of the inverters and NAND and NOR gates in each circuit and store their outputs under zero-bias conditions. Therefore, NS FBFETs are promising components for next-generation LIM.
Hard ferromagnetism in van der Waals Fe3GaTe2 nanoflake down to monolayer
Authors: Wang Mingjie , Lei Bin , Zhu Kejia , Deng Yazhou , Tian Mingliang , Xiang Ziji , Wu Tao , Chen Xianhui 
Published: March 2024

AbstractTwo-dimensional (2D) magnetic materials are of not only fundamental scientific interest but also promising candidates for numerous applications. However, so far only a few intrinsic magnets with long-ranged order down to the 2D limit have been experimentally established. Here, we report that the intrinsic 2D ferromagnetism can be realized in van der Waals (vdW) Fe3GaTe2 nanoflake down to monolayer. By measuring the Hall resistance and magnetoresistance, we demonstrate that the Fe3GaTe2 monolayer exhibits 2D hard ferromagnetism with record-high Cure temperature (Tc) of 240 K for the monolayer of known intrinsic ferromagnets. Both of square-shaped hysteresis loops with near-vertical jump in anomalous Hall effect (AHE) and the negative magnetoresistance (NMR) behavior with an applied out-of-plane magnetic field reveal robust perpendicular magnetic anisotropy (PMA) in Fe3GaTe2 nanoflakes down to the monolayer limit. Furthermore, we find the intrinsic mechanism that stems from the Berry curvature of electronic bands dominates AHE of nanoflakes in the low temperature range. Our results not only provide an excellent candidate material for next-generation spintronic applications, but also open up a platform for exploring physical mechanisms in 2D ferromagnetism.
Evaluating reliability in wearable devices for sleep staging
Authors: Birrer Vera , Elgendi Mohamed , Lambercy Olivier , Menon Carlo 
Published: March 2024

AbstractSleep is crucial for physical and mental health, but traditional sleep quality assessment methods have limitations. This scoping review analyzes 35 articles from the past decade, evaluating 62 wearable setups with varying sensors, algorithms, and features. Our analysis indicates a trend towards combining accelerometer and photoplethysmography (PPG) data for out-of-lab sleep staging. Devices using only accelerometer data are effective for sleep/wake detection but fall short in identifying multiple sleep stages, unlike those incorporating PPG signals. To enhance the reliability of sleep staging wearables, we propose five recommendations: (1) Algorithm validation with equity, diversity, and inclusion considerations, (2) Comparative performance analysis of commercial algorithms across multiple sleep stages, (3) Exploration of feature impacts on algorithm accuracy, (4) Consistent reporting of performance metrics for objective reliability assessment, and (5) Encouragement of open-source classifier and data availability. Implementing these recommendations can improve the accuracy and reliability of sleep staging algorithms in wearables, solidifying their value in research and clinical settings.
Technology-supported behavior change interventions for reducing sodium intake in adults: a systematic review and meta-analysis
Authors: Yan Yong Yang , Chan Lily Man Lee , Wang Man Ping , Kwok Jojo Yan Yan , Anderson Craig S. , Lee Jung Jae 
Published: March 2024

AbstractThe effects of technology-supported behavior change interventions for reducing sodium intake on health outcomes in adults are inconclusive. Effective intervention characteristics associated with sodium reduction have yet to be identified. A systematic review and meta-analysis were conducted, searching randomized controlled trials (RCTs) published between January 2000 and April 2023 across 5 databases (PROSPERO: CRD42022357905). Meta-analyses using random-effects models were performed on 24-h urinary sodium (24HUNa), systolic blood pressure (SBP), and diastolic blood pressure (DBP). Subgroup analysis and meta-regression of 24HUNa were performed to identify effective intervention characteristics. Eighteen RCTs involving 3505 participants (51.5% female, mean age 51.6 years) were included. Technology-supported behavior change interventions for reducing sodium intake significantly reduced 24HUNa (mean difference [MD] −0.39 gm/24 h, 95% confidence interval [CI] −0.50 to −0.27; I2 = 24%), SBP (MD −2.67 mmHg, 95% CI −4.06 to −1.29; I2 = 40%), and DBP (MD −1.39 mmHg, 95% CI −2.31 to −0.48; I2 = 31%), compared to control conditions. Interventions delivered more frequently (≤weekly) were associated with a significantly larger effect size in 24HUNa reduction compared to less frequent interventions (>weekly). Other intervention characteristics, such as intervention delivery via instant messaging and participant-family dyad involvement, were associated with larger, albeit non-significant, effect sizes in 24HUNa reduction when compared to other subgroups. Technology-supported behavior change interventions aimed at reducing sodium intake were effective in reducing 24HUNa, SBP, and DBP at post-intervention. Effective intervention characteristics identified in this review should be considered to develop sodium intake reduction interventions and tested in future trials, particularly for its long-term effects.
Effect of clinical decision support for severe hypercholesterolemia on low-density lipoprotein cholesterol levels
Authors: Bangash Hana , Saadatagah Seyedmohammad , Naderian Mohammadreza , Hamed Marwan E. , Alhalabi Lubna , Sherafati Alborz , Sutton Joseph , Elsekaily Omar , Mir Ali , Gundelach Justin H. , Gibbons Daniel , Johnsen Paul , Wood-Wentz Christina M. , Smith Carin Y. , Caraballo Pedro J. , Bailey Kent R. , Kullo Iftikhar J. 
Published: March 2024

AbstractSevere hypercholesterolemia/possible familial hypercholesterolemia (FH) is relatively common but underdiagnosed and undertreated. We investigated whether implementing clinical decision support (CDS) was associated with lower low-density lipoprotein cholesterol (LDL-C) in patients with severe hypercholesterolemia/possible FH (LDL-C ≥ 190 mg/dL). As part of a pre-post implementation study, a CDS alert was deployed in the electronic health record (EHR) in a large health system comprising 3 main sites, 16 hospitals and 53 clinics. Data were collected for 3 months before (‘silent mode’) and after (‘active mode’) its implementation. Clinicians were only able to view the alert in the EHR during active mode. We matched individuals 1:1 in both modes, based on age, sex, and baseline lipid lowering therapy (LLT). The primary outcome was difference in LDL-C between the two groups and the secondary outcome was initiation/intensification of LLT after alert trigger. We identified 800 matched patients in each mode (mean ± SD age 56.1 ± 11.8 y vs. 55.9 ± 11.8 y; 36.0% male in both groups; mean ± SD initial LDL-C 211.3 ± 27.4 mg/dL vs. 209.8 ± 23.9 mg/dL; 11.2% on LLT at baseline in each group). LDL-C levels were 6.6 mg/dL lower (95% CI, −10.7 to −2.5; P = 0.002) in active vs. silent mode. The odds of high-intensity statin use (OR, 1.78; 95% CI, 1.41–2.23; P < 0.001) and LLT initiation/intensification (OR, 1.30, 95% CI, 1.06–1.58, P = 0.01) were higher in active vs. silent mode. Implementation of a CDS was associated with lowering of LDL-C levels in patients with severe hypercholesterolemia/possible FH, likely due to higher rates of clinician led LLT initiation/intensification.
Housing policies and energy efficiency spillovers in low and moderate income communities
Authors: Asensio Omar Isaac , Churkina Olga , Rafter Becky D. , O’Hare Kira E. 
Published: March 2024

AbstractHousing policies address the human dimensions of increasing urban density, but their energy and sustainability implications are hard to measure due to challenges with siloed civic data. This is especially critical when evaluating policies targeting low- and moderate-income (LMI) households. For example, a major challenge to achieving national energy efficiency goals has been participation by LMI households. Standalone energy efficiency policies, such as information-based programmes and weatherization assistance, tend to attract affluent, informed households or suffer from low participation rates. In this Article, we provide evidence that federal housing policies, specifically community development block grants, accelerate energy efficiency participation from LMI households, including renters and multifamily residents. We conduct record linkage on 5.9M observations of housing programme participation and utility consumption to quantify the hidden benefits of locally administered housing block grants in a typical entitlement community in the US Southeast. We provide long-run evidence across 16,680 properties that housing policies generate 5–11% energy savings as spillover benefits to economically burdened households not conventionally targeted for energy efficiency participation.
A theoretical framework to improve the adoption of green Integrated Pest Management tactics
Authors: Han Peng , Rodriguez-Saona Cesar , Zalucki Myron P. , Liu Shu-sheng , Desneux Nicolas 
Published: March 2024

AbstractSustainable agriculture relies on implementing effective, eco-friendly crop protection strategies. However, the adoption of these green tactics by growers is limited by their high costs resulting from the insufficient integration of various components of Integrated Pest Management (IPM). In response, we propose a framework within IPM termed Multi-Dimensional Management of Multiple Pests (3MP). Within this framework, a spatial dimension considers the interactive effects of soil-crop-pest-natural enemy networks on pest prevalence, while a time dimension addresses pest interactions over the crop season. The 3MP framework aims to bolster the adoption of green IPM tactics, thereby extending environmental benefits beyond crop protection.
Brain-derived endothelial cells are neuroprotective in a chronic cerebral hypoperfusion mouse model
Authors: Matsui Yuichi , Muramatsu Fumitaka , Nakamura Hajime , Noda Yoshimi , Matsumoto Kinnosuke , Kishima Haruhiko , Takakura Nobuyuki 
Published: March 2024

AbstractWhether organ-specific regeneration is induced by organ-specific endothelial cells (ECs) remains unelucidated. The formation of white matter lesions due to chronic cerebral hypoperfusion causes cognitive decline, depression, motor dysfunction, and even acute ischemic stroke. Vascular ECs are an important target for treating chronic cerebral hypoperfusion. Brain-derived ECs transplanted into a mouse chronic cerebral hypoperfusion model showed excellent angiogenic potential. They were also associated with reducing both white matter lesions and brain dysfunction possibly due to the high expression of neuroprotective humoral factors. The in vitro coculture of brain cells with ECs from several diverse organs suggested the function of brain-derived endothelium is affected within a brain environment due to netrin-1 and Unc 5B systems. We found brain CD157-positive ECs were more proliferative and beneficial in a mouse model of chronic cerebral hypoperfusion than CD157-negative ECs upon inoculation. We propose novel methods to improve the symptoms of chronic cerebral hypoperfusion using CD157-positive ECs.
Activation of GPR81 by lactate drives tumour-induced cachexia
Authors: Liu Xidan , Li Shijin , Cui Qionghua , Guo Bujing , Ding Wanqiu , Liu Jie , Quan Li , Li Xiaochuan , Xie Peng , Jin Li , Sheng Ye , Chen Wenxin , Wang Kai , Zeng Fanxin , Qiu Yifu , Liu Changlu , Zhang Yan , Lv Fengxiang , Hu Xinli , Xiao Rui-Ping 
Published: March 2024

AbstractCachexia affects 50–80% of patients with cancer and accounts for 20% of cancer-related death, but the underlying mechanism driving cachexia remains elusive. Here we show that circulating lactate levels positively correlate with the degree of body weight loss in male and female patients suffering from cancer cachexia, as well as in clinically relevant mouse models. Lactate infusion per se is sufficient to trigger a cachectic phenotype in tumour-free mice in a dose-dependent manner. Furthermore, we demonstrate that adipose-specific G-protein-coupled receptor (GPR)81 ablation, similarly to global GPR81 deficiency, ameliorates lactate-induced or tumour-induced adipose and muscle wasting in male mice, revealing adipose GPR81 as the major mediator of the catabolic effects of lactate. Mechanistically, lactate/GPR81-induced cachexia occurs independently of the well-established protein kinase A catabolic pathway, but it is mediated by a signalling cascade sequentially activating Gi–Gβγ–RhoA/ROCK1–p38. These findings highlight the therapeutic potential of targeting GPR81 for the treatment of this life-threatening complication of cancer.
Metformin and feeding increase levels of the appetite-suppressing metabolite Lac-Phe in humans
Authors: Scott Barry , Day Emily A. , O’Brien Katie L. , Scanlan John , Cromwell Grace , Scannail Aine Ni , McDonnell Marie E. , Finlay David K. , Lynch Lydia 
Published: March 2024

AbstractMetformin, a widely used first-line treatment for type 2 diabetes (T2D), is known to reduce blood glucose levels and suppress appetite. Here we report a significant elevation of the appetite-suppressing metabolite N-lactoyl phenylalanine (Lac-Phe) in the blood of individuals treated with metformin across seven observational and interventional studies. Furthermore, Lac-Phe levels were found to rise in response to acute metformin administration and post-prandially in patients with T2D or in metabolically healthy volunteers.
Towards transparent and durable copper-containing antimicrobial surfaces
Authors: Graham Christina , Mezzadrelli Alessia , Senaratne Wageesha , Pal Santona , Thelen Dean , Hepburn Lisa , Mazumder Prantik , Pruneri Valerio 
Published: March 2024

AbstractMetallic copper is a potent antimicrobial agent with high efficacy against a range of microorganisms. Whilst it is commonplace for objects such as door handles and hospital bedrails to be made of or to be coated with copper, other high-touch surfaces such as those of screens and monitors would lose their optical transparency. Herein, we report the design of a transparent antimicrobial nanostructured copper surface obtained by dewetting ultrathin metal copper films on glass. Antimicrobial effectiveness of >99.9 % was obtained within 2 h against Staphylococcus aureus following the US Environmental Protection Agency Test method. Moreover, the proposed surfaces show an average transmittance between 70–80% with little color in the visible range. Additionally, they maintain optical and antimicrobial properties after abrasion and chemical exposure tests designed to replicate physical wear and repeated exposure to biocidal cleaning materials. With the demonstrated surfaces’ antimicrobial, colorless, and durability properties, they have potential in applications such as touch-enabled public or personal displays once higher transparency is achieved.
High-resolution computed tomography with scattered X-ray radiation and a single pixel detector
Authors: Ben-Yehuda A. , Sefi O. , Klein Y. , Schwartz H. , Cohen E. , Shukrun R. H. , Shwartz S. 
Published: March 2024

AbstractX-ray imaging is a prevalent technique for non-invasively visualizing the interior of the human body and other opaque samples. In most commercial X-ray modalities, an image is formed by measuring the X-rays that pass through the object of interest. However, despite the potential of scattered radiation to provide additional information about the object, it is often disregarded due to its inherent tendency to cause blurring. Consequently, conventional imaging modalities do not measure or utilize these valuable data. In contrast, we propose and experimentally demonstrate a high resolution technique for X-ray computed tomography (CT) that measures scattered radiation by exploiting computational ghost imaging (CGI). We show that the resolution of our method can exceed 500 µm, which is approximately an order of magnitude higher than the typical resolution of X-ray imaging modalities based on scattered radiation. Our research reveals a promising technique for incorporating scattered radiation data in CT scans to improve image contrast and resolution while minimizing radiation exposure for patients. The findings of our study suggest that our technique could represent a significant advancement in the fields of medical and industrial imaging, with the potential to enhance the accuracy and safety of diagnostic imaging procedures.
Energy efficient photonic memory based on electrically programmable embedded III-V/Si memristors: switches and filters
Authors: Cheung Stanley , Tossoun Bassem , Yuan Yuan , Peng Yiwei , Hu Yingtao , Sorin Wayne V. , Kurczveil Geza , Liang Di , Beausoleil Raymond G. 
Published: March 2024

AbstractOver the past few years, extensive work on optical neural networks has been investigated in hopes of achieving orders of magnitude improvement in energy efficiency and compute density via all-optical matrix-vector multiplication. However, these solutions are limited by a lack of high-speed power power-efficient phase tuners, on-chip non-volatile memory, and a proper material platform that can heterogeneously integrate all the necessary components needed onto a single chip. We address these issues by demonstrating embedded multi-layer HfO2/Al2O3 memristors with III-V/Si photonics which facilitate non-volatile optical functionality for a variety of devices such as Mach-Zehnder Interferometers, and (de-)interleaver filters. The Mach-Zehnder optical memristor exhibits non-volatile optical phase shifts > π with ~33 dB signal extinction while consuming 0 electrical power consumption. We demonstrate 6 non-volatile states each capable of 4 Gbps modulation. (De-) interleaver filters were demonstrated to exhibit memristive non-volatile passband transformation with full set/reset states. Time duration tests were performed on all devices and indicated non-volatility up to 24 hours and beyond. We demonstrate non-volatile III-V/Si optical memristors with large electric-field driven phase shifts and reconfigurable filters with true 0 static power consumption. As a result, co-integrated photonic memristors offer a pathway for in-memory optical computing and large-scale non-volatile photonic circuits.