bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recognition, diagnosis, and operability assessment of chronic thromboembolic pulmonary hypertension (CTEPH): A global cross‐sectional scientific survey (CLARITY)
Authors: Kopeć Grzegorz , Forfia Paul , Abe Kohtaro , Beaudet Amélie , Gressin Virginie , Jevnikar Mitja , Meijer Catherina , Tan Yan Zhi , Moiseeva Olga , Sheares Karen , Skoro‐Sajer Nika , Terra‐Filho Mario , Whitford Helen , Zhai Zhenguo , Heresi Gustavo A. 
Published: February 2024

AbstractEarly recognition and diagnosis of chronic thromboembolic pulmonary hypertension (CTEPH) is crucial for improving prognosis and reducing the disease burden. Established clinical practice guidelines describe interventions for the diagnosis and evaluation of CTEPH, yet limited insight remains into clinical practice variation and barriers to care. The CTEPH global cross‐sectional scientific survey (CLARITY) was developed to gather insights into the current diagnosis, treatment, and management of CTEPH and to identify unmet medical needs. This paper focuses on the recognition and diagnosis of CTEPH and the referral and evaluation of these patients. The survey was offered to hospital‐based medical specialists through Scientific Societies and other medical organizations, from September 2021 to May 2022. Response data from 353 physicians showed that self‐reported awareness of CTEPH increased over the past 10 years among 96% of respondents. Clinical practices in acute pulmonary embolism (PE) follow‐up and CTEPH diagnosis differed among respondents. While 50% of respondents working in a nonexpert center reported to refer patients to an expert pulmonary hypertension/CTEPH center when CTEPH is suspected, 51% of these physicians did not report referral of patients with a confirmed diagnosis for further evaluation. Up to 50% of respondents involved in the evaluation of referred patients have concluded a different operability status than that indicated by the referring center. This study indicates that early diagnosis and timely treatment of CTEPH is challenged by suboptimal acute PE follow‐up and patient referral practices. Nonadherence to guideline recommendations may be impacted by various barriers to care, which were shown to vary by geographical region.
Two cases of idiopathic pulmonary fibrosis evaluated by dynamic digital radiography for diaphragmatic motion and disease progression
Authors: Nikaido Takefumi , Tanino Yoshinori , Sato Yuki , Togawa Ryuichi , Kawamata Takaya , Watanabe Natsumi , Minemura Hiroyuki , Ono Kojiro , Sato Katsumasa , Shibata Yoko 
Published: February 2024

AbstractForced vital capacity has been utilized as a parameter of disease progression in idiopathic pulmonary fibrosis (IPF); however, its measurement is difficult when patients do not understand or cooperate. Dynamic digital radiography (DDR) enables sequential chest X‐ray imaging during breathing, with lower radiation doses compared to conventional fluoroscopy or computed tomography. There is accumulating evidence showing that parameters obtained from DDR, particularly those related to diaphragmatic dynamics, are correlated with pulmonary function parameters, and are useful for pathophysiological evaluation. We herein present two cases that suggest parameters obtained from DDR during supine normal tidal breathing may predict disease progression of IPF.
Molecular modeling studies of Indoline Scaffold derivatives as PD‐1/PD‐L1 pathway inhibitors by QSAR, molecular docking and molecular dynamics simulation techniques
Authors: Tong Jian‐Bo , Gao Peng , Xiao Xue‐Chun , Liu Yuan , Xu Hai‐Yin 
Published: February 2024

AbstractIn recent years, blocking the interaction of programmed cell death receptor‐1 (PD‐1) and programmed cell death ligand‐1 (PD‐L1) has been recognized as one of the promising cancer therapies. Due to the many limitations of monoclonal antibodies, the development of small molecule inhibitors targeting PD‐1/PD‐L1 is imminent. This study aims to systematically investigate the interaction mechanisms of novel PD‐1/PD‐L1 inhibitors containing indoline backbone structures using 3D/2D‐QSAR modeling, molecular docking, molecular dynamics (MD) simulation, and ADMET prediction. The performance and predictive ability of the constructed QSAR models were evaluated by internal and external validation techniques. Topomer CoMFA and HQSAR models showed good reliability and predictive capability. By searching for R‐groups in the Topomer search module and combining the existing molecules with high activity contribution values, 24 new compounds with theoretically high activity were obtained, which showed desirable docking scores, appropriate ADMET properties, and good stability. This work not only provides a reliable QSAR model as a valuable screening tool for the development of future drugs targeting PD‐1/PD‐L1, but also makes the newly designed inhibitors expected to be potential PD‐1/PD‐L1 inhibitors that can be used for further synthesis and characterization to obtain novel anti‐cancer drugs targeting PD‐1/PD‐L1.
Nanoengineering of Lanthanide‐Doped BaGdF5‐Graphene Oxide as a Tunable‐Nanocomposite Platform for Biological Applications
Authors: Lal Kewat Heera , Nath Chouryal Yogendra , Kumar Sharma Rahul , Jyoti Mondal Dibya , Abdullah Wani Ishfaq , Waghmare Ashwini , Konar Sanjit , Nigam Sandeep , Bhargava Yogesh , Ghosh Pushpal 
Published: February 2024

AbstractInorganic nanohosts doped with lanthanide ions are an indispensable tool for multimodal bioimaging and MRI applications due to their distinctive optical, magnetic, and biocompatible properties. Nanocomposites of such nanoprobes with functionalization capabilities could also enable their use in targeted therapy‐based applications. However, the influence of nanocomponents especially their proportion in a nanocomposite in modulating the physio‐chemical and biocompatibility properties of the nanocomposite is still elusive. To address this knowledge gap, we have engineered nanocomposites variants using an environmentally benign one‐step synthesis with ionic liquids. We have synthesized two nanocomposites, differing in the proportion of lanthanide‐doped ternary fluoride nanoparticles (as nanophase material with luminescent and magnetic traits) and graphene oxide (as host matrix phase with tunable functionalization potential for theranostics applications). We found that with increased GO nanomaterial, nanocomposites showed reduced crystallite size and photoluminescence properties without significantly affecting the magnetic traits. Thus, implying nanocomponents ratio has differential effect on the nanocomposite properties. To assess biocompatibility, we have employed sensitive biomarkers such as craniofacial development, cardiac rhythm, and overall survivability of zebrafish larvae. Remarkably, biocompatibility improved when the proportion of the GO was increased within the nanocomposite as compared to when the nanocomponents were assessed individually. Our results also revealed that biocompatibility of nanocomposites also depends on the synergistic interplay between the nanocomponents due to the spatial arrangement of each nanocomponent in the nanocomposites. Overall, our study offers an intriguing avenue for tuning the biocompatibility of such nanocomposites, rendering them as an application‐independent biocompatible‐platform for theranostics applications.
miRNA‐21 Inhibitor‐Loaded Cationic Liposomes Development using the Quality by Design Approach
Authors: Toma Ioana , Tefas Lucia Ruxandra , Raduly Lajos , Zanoaga Oana , Jurj Ancuta , Hales Dana , Porfire Alina Silvia , Berindan‐Neagoe Ioana , Tomuta Ioan 
Published: February 2024

AbstractThe success of efficiently delivering genetic material to target cells depends on developing an appropriate vector. Among the variety of nanocarriers used for gene therapy, cationic liposomes are the most investigated for delivering genetic material in different forms of cancer. Cationic liposomes contain lipids with positively charged head groups that form electrostatic bonds with the negatively charged phosphate group of nucleic acids, ensuring efficient loading of the genetic material. The aim of this study was the development and in vitro characterization of liposomal formulations for genetic material delivery using the Quality by Design (QbD) approach. We have employed the Design of Experiments (DoE) methodology to study the impact of selected formulation factors on the quality of the proposed non‐viral vectors. Among the varied factors, the ones that had an impact on the responses were the total lipid concentration and cationic lipid concentration. Two liposomal formulations with adequate critical quality attributes (CQAs) were selected for miRNA‐21 inhibitor encapsulation. We continued with the in vitro evaluation on lung cancer cell line. Fluorescence microscopy helped visualize the internalization of all liposomal formulations and apoptotic effects. Finally, we evaluated the cellular viability and migration events after treatment with the cationic liposomes.
Three New Biflavonoids from Selaginella delicatula (Desv. ex Poir.) Alston
Authors: Kang Shi‐Wen , Wang Cong‐Wei , Bahetjan Yerlan , Zheng Ni , Liu Wen‐Qi , Wan Ding‐Rong , Zhou Xiu‐Teng , Pang Ke‐Jian , Yang Xin‐Zhou 
Published: February 2024

AbstractTen compounds, including three new bioflavonoids (1–3) and seven known compounds (4–10), were identified in the ethyl acetate fraction of the 85 % ethanol extract of Selaginella delicatula. The structures of the new compounds were determined through spectroscopic data analysis, and their absolute configurations were established using circular dichroism (CD). All the isolated compounds were tested for their antiproliferative effects on MCF‐7, HepG2, and HEK 293T cells. Compounds 1 and 5 exhibited significant cytotoxicity against MCF‐7 cells, effectively inhibiting their proliferation. Meanwhile, compounds 1, 2, 5, and 7 respectively exhibited strong inhibitory effects on HepG2 cells. Furthermore, when we combined the IC50 values of compounds 3, 5, and 7 on HEK 293T cells, we discovered that they selectively inhibited cell growth.
Synthesis of 1‐phenyl‐3‐(quinolin‐8‐ylamino)prop‐2‐en‐1‐one and analysis of its structure by X‐ray crystallography, NMR, UV‐Vis spectroscopy and DFT calculations
Authors: Volkov Michael Yu. , Sharipova Alsu R. , Turanova Olga A. , Gubaidullin Aidar T. , Shaidullina Amina F. , Savostina Ludmila I. , Turanov Alexander N. 
Published: February 2024

Abstract1‐phenyl‐3‐(quinolin‐8‐ylamino)prop‐2‐en‐1‐one was obtained by a two‐step synthesis. From X‐ray crystallography, NMR and UV‐vis spectra it follows that in the crystalline state and in solutions, regardless of the polarity of the solvent, 1‐phenyl‐3‐(quinolin‐8‐ylamino)prop‐2‐en‐1‐one exists in the ketone form of the cis‐isomer. DFT calculations confirmed that the cis‐isomer is the most energetically favorable among all its isomers.
Ligand‐assisted Palladium Catalyzed C5 Arylation Reaction of Imidazoles with Aryl Chlorides
Authors: Wang Yu , Liu Ning , Bu Qingqing 
Published: February 2024

AbstractA series of asymmetric pyridine‐bridged imidazole‐pyridine‐amino acid ligands was successfully synthesized and characterized by HR‐MS, 1H, 13C NMR spectroscopy. These ligands assisted palladium catalyzed C−H bond activation of imidazoles at the C5 position with aryl chlorides and aryl bromides without pivalic acid conditions. Various of less reactive aryl chlorides were allowed to prepare arylated heterocycles. The mechanism study indicated the structure role for amino acid and imidazole.
Design, Synthesis, and In‐Vitro Evaluation of Novel Butanoic Acid Derivatives as Potential Soluble Epoxide Hydrolase Inhibitors
Authors: Saeedi Saeedeh , Mahboubi‐Rabbani Mohammad , Rezaee Elham , Tabatabai Sayyed Abbas 
Published: February 2024

AbstractSoluble epoxide hydrolase (sEH) enzyme has been proposed as a promising target for the treatment of several peripheral inflammatory‐related diseases. The most potent sEH inhibitors are urea or amide‐based which play active‐site transition state mimic and often suffer from poor solubility and low bioavailability. Therefore, the development of novel sEH inhibitors with improved pharmacokinetic specification is a great deal of attention. In this study, amide‐based sEH inhibitors bearing N′‐acetylacetohydrazide/oxadiazole moieties as the primary (P1) and carboxyl/amide as secondary pharmacophores (P2) were designed, synthesized, and biologically evaluated. All the structures were confirmed via recruiting spectral data. Docking results demonstrated that the primary pharmacophore (P1) fit properly in the corresponding binding site of the enzyme, possessing appropriate distances for effective hydrogen bonding to the crucial amino acids, including Asp335. In agreement with the findings of docking studies, a number of compounds were found to possess moderate to high in‐vitro sEH inhibitory activities, and two compounds were identified as the most potent inhibitors with IC50 values of 7.8 and 10.98 nM, respectively. Furthermore, ADME properties of the newly designed analogs were analyzed in silico and the results showed that these compounds have the proper potential for being developed as new sEH inhibitors.
Improving Fast‐Charging Capability of High‐Voltage Spinel LiNi0.5Mn1.5O4 Cathode under Long‐Term Cyclability through Co‐Doping Strategy
Authors: Gao Xin , Hai Feng , Chen Wenting , Yi Yikun , Guo Jingyu , Xue Weicheng , Tang Wei , Li Mingtao 
Published: February 2024

AbstractCo‐free spinel LiNi0.5Mn1.5O4 (LNMO) is emerging as a promising contender for designing next generation high‐energy‐density and fast‐charging Li‐ion batteries, due to its high operating voltage and good Li+ diffusion rate. However, further improvement of the Li+ diffusion ability and simultaneous resolution of Mn dissolution still pose significant challenges for their practical application. To tackle these challenges, a simple co‐doping strategy is proposed. Compared to Pure‐LNMO, the extended lattice in resulting LNMO‐SbF sample provides wider Li+ migration channels, ensuring both enhanced Li+ transport kinetics, and lower energy barrier. Moreover, Sb creating structural pillar and stronger TM─F bond together provides a stabilized spinel structure, which stems from the suppression of detrimental irreversible phase transformation during cycling related to Mn dissolution. Benefiting from the synergistic effect, the LNMO‐SbF material exhibits a superior reversible capacity (111.4 mAh g−1 at 5C, and 70.2 mAh g−1 after 450 cycles at 10C) and excellent long‐term cycling stability at high current density (69.4% capacity retention at 5C after 1000 cycles). Furthermore, the LNMO‐SbF//graphite full cell delivers an exceptional retention rate of 96.9% after 300 cycles, and provides a high energy density at 3C even with a high loading. This work provides valuable insight into the design of fast‐charging cathode materials for future high energy density lithium‐ion batteries.
“Women are capable too!” Exploring intersectionality and challenging CaLD gender stereotypes at Australian universities
Authors: Tankosić Ana , Dovchin Sender 
Published: February 2024

AbstractWith a focus on Culturally and Linguistically Diverse (CaLD) women, this article will discuss the underlying gender inequalities and stereotypes these women experience in Australian tertiary institutions through reflections of translingual discrimination. Translingual discrimination refers to the ideologies and practices that produce unequal linguistic power relationships between CaLD communities and dominant communities of the host society, focusing on the central role that language plays in the enduring relevance of discrimination disparity. Because of CaLD women's translingual identities, these groups experience such aspects of translingual discrimination as accentism, naming practices, linguistic subordination, deskilling, and stereotyping, which eventually affect their well‐being and economic security. CaLD women need a linguistically and culturally “safe space” where they will be supported and appreciated based on their capabilities and skills and not subjected to objectification, femininity evaluations, and derogatory actions. Opportunities for women should persist because, unfortunately, in men‐dominated fields, these opportunities are still necessary to support and include women.
Interactions between the metabolic syndrome and alcohol consumption increases the risk of liver disease
Authors: Hagström Hannes , Hegmar Hannes , Moreno Christophe 
Published: February 2024

AbstractAlcohol‐related liver disease (ALD) and non‐alcoholic fatty liver disease (NAFLD, recently renamed metabolic dysfunction‐associated steatotic liver disease [MASLD]) share many features, including certain pathophysiological mechanisms, susceptibility genes, and histological lesions. However, the natural history of the two diseases, studied separately, is significantly different, with ALD being associated with a higher risk of cirrhosis and liver‐related mortality. Moreover, evidence suggests an interactive effect between ALD and metabolic risk factors that are associated with NAFLD on the risk of progressive fibrosis and development of cirrhosis. Patients with both a high consumption of alcohol and metabolic risk factors, such as obesity or diabetes, should therefore be considered a particularly high‐risk group for cirrhosis. Additional studies regarding the efficacy of screening for advanced liver fibrosis or cirrhosis in these risk groups are needed. The most effective and established method for reducing the risk of progression in ALD is alcohol abstinence, whereas weight loss is effective in NAFLD. In this narrative review, we introduce the reader to the literature of the field and present key studies showing this interactive effect.
Effects of TPU on the mechanical properties, fracture toughness, morphology, and thermal analysis of 3D‐printed ABS‐TPU blends by FDM
Authors: Soltanmohammadi Kianoosh , Rahmatabadi Davood , Aberoumand Mohammad , Soleyman Elyas , Ghasemi Ismaeil , Baniassadi Majid , Abrinia Karen , Bodaghi Mahdi , Baghani Mostafa 
Published: February 2024

AbstractIn this paper, blends of ABS‐TPU with two different weight percentages of TPU were prepared using fused deposition modeling technology. The effect of adding TPU on the fracture toughness of ABS and mechanical properties was comprehensively studied. Tensile, compression, fracture toughness, and shear tests were conducted on the 3D‐printed samples. Thermal and microstructural analyses were performed using dynamic mechanical thermal analysis (DMTA), and scanning electron microscope (SEM). The DMTA results showed that adding TPU decreased the storage modulus and the glass transition temperature of ABS, as well as its peak intensity. The mechanical test results showed that adding TPU decreased the strength but increased the formability and elongation of the samples. Fracture tests showed that the addition of TPU decreased the maximum force needed for a crack to initiate. The force required for crack initiation decreased from 568.4 N for neat ABS to 335.3 N for ABS80 and 123.2 N for ABS60. The ABS60 blend exhibited the highest strength against crack growth, indicating that TPU can change the behavior of ABS from brittle to ductile. Shear test results and SEM images also showed good adhesion strength between the printed samples for all three specimens, indicating their good printability. Adding TPU resulted in a reduction in the size and number of voids and holes between the printed layers.Highlights
Melt mixing, filament preparation, and 3D printing of ABS‐TPU blends.
Investigation of mechanical properties, microstructure, and fracture toughness.
Improved resistance to crack growth and elongation by adding TPU to ABS.
Improving printability and reducing microholes in blends compared with ABS.
Achieving a wide range of mechanical properties for various applications.
Computed tomographic assessment of bronchoesophageal artery hypertrophy and systemic‐to‐pulmonary shunt mimicking a persistent ductus arteriosus in a French Bulldog
Authors: Manzoni Sara , Van Israël Nicole , Quinci Manuela , Specchi Swan , Bongartz Alexandre 
Published: February 2024

AbstractA 5‐year‐old, female French bulldog was evaluated for left‐sided congestive heart failure. A diagnosis of bronchoesophageal artery hypertrophy with systemic‐to‐pulmonary shunt was made. Even though Doppler echocardiographic findings were in favour of a left‐to‐right shunting patent ductus arteriosus, the exploratory thoracotomy highlighted a more complex vascular anomaly. An angiographic computed tomography study allowed to establish the final diagnosis. Bronchial‐to‐pulmonary artery shunts can mimic the presence of a patent ductus arteriosus, therefore computed tomography is considered a valuable additional tool for diagnosis and surgical planning.
Introduction
Authors: Aylsworth Timothy , Castro Clinton 
Published: February 2024

AbstractIn this chapter, we summarize the main arguments of the book. Our central thesis is that the moral weight of autonomy gives us reasons to restructure our relationship with mobile devices and the attention economy. In Chap. 2, we explain what autonomy is and why it matters morally. In Chap. 3, we present empirical evidence to justify our concern with mobile devices. We then turn, in Chap. 4, to Kantian moral arguments about the duty we owe to ourselves to protect and safeguard our capacities. We extend this argument in Chap. 5 by discussing duties we owe to others (especially parents to children, teachers to students, employers to employees, and developers to users). In Chap. 6, we explore the possibility of using government regulation to rein in the attention economy, and we justify these arguments by means of Kant’s political philosophy. Having exhausted our concerns with individual-level autonomy, we discuss group-level autonomy in Chap. 7, and we argue that the attention economy contributes to things like polarization which put a drag on democratic legitimacy. We conclude in Chap. 8 by taking stock of our arguments and offering some reasons for optimism.
Conclusion
Authors: Aylsworth Timothy , Castro Clinton 
Published: February 2024

AbstractHere we offer some concluding remarks and take stock of the arguments made throughout the book. We revisit the three examples from the first chapter, using the conclusions of previous chapters to explain what is going wrong in those scenarios. Each case demonstrates different ways that the attention economy threatens to undermine autonomy, and they underscore the importance of the moral obligations we defended in previous chapters. We conclude by offering some reasons to be optimistic about this situation and to hope that the situation will begin to improve once we start taking steps (both collectively and individually) to address these issues.
Revisiting renormalization group equations of the SMEFT dimension-seven operators
Authors: Zhang Di 
Published: February 2024

Abstract
In this work, we revisit the renormalization group equations (RGEs) of dimension-seven (dim-7) operators in the Standard Model effective field theory (SMEFT) resulting from mixing among dim-7 operators themselves by means of the background field method. Adopting a recently proposed physical basis for dim-7 operators, we achieve the explicit RGEs of all non-redundant dim-7 operators in the SMEFT for the first time. Together with those originating from the dim-5 and dim-6 operators, these results constitute the complete RGEs of dim-7 operators, and hence can be exploited to study full RG-running effects on some lepton- or baryon-number-violating processes involving dim-7 operators in the SMEFT, such as neutrino masses, neutrinoless double beta decay, meson and nucleon decays. We perform an analysis of the structure and perturbative power counting of the obtained one-loop anomalous dimension matrix, which is consistent with a non-renormalization theorem and the naive dimension analysis. Additionally, a partial check on some results is carried out by means of different tools and quantum field gauges.