bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is a New Chinese Literary History Possible? A Critical Investigation of The Cambridge History of Chinese Literature
Authors: Shen Yifan 
Published: April 2024

Abstract
The publication of The Cambridge History of Chinese Literature in 2010 stands as a significant achievement in the field of Chinese literary studies within the global field of Sinology. This groundbreaking work challenged the prevailing narratives of Chinese literary history in two key areas: writing style and perspectives of literary history. By employing updated methodologies, the authors addressed the practical question of how to effectively rewrite Chinese literary history. Additionally, they relied on historiographic principles to reconsider the theoretical issues surrounding the nature of Chinese literary history and the reasons behind its rewriting. Through a comprehensive investigation, this literary history offers a theoretical response to the question of what Chinese literary history truly entails. It sheds light on two fundamental compilation principles: the history of history and the history of literary culture. These principles revolve around the three core elements of history, literature, and China itself. By examining the book’s interactions with the mainstream Western theoretical community, insight may be gained into the motivations behind the writing process and the paradigmatic shifts within contemporary overseas Chinese literary history.
Chemical composition and amino acids of Locusta migratoria (Orthoptera Acrididae) fed wheat seedlings (Triticum aestivum) or rape leaves (Brassica napus)
Authors: Cao K.L. , Yin Y. , Li S.S. , Li M.Q. , Tajdar A. , Tan S.Q. , Shi W.P. 
Published: April 2024

Abstract
Locusts have high nutritional value and are considered alternative protein sources for humans and animals. Diet can strongly affect the nutritional composition of insects. In this study, the influences of diets – wheat (Triticum aestivum) seedlings and rape (Brassica napus) leaves – on the chemical composition and amino acids of the migratory locust (Locusta migratoria) were assessed. The crude protein, soluble carbohydrate and triglyceride were analyzed using the Bradford method, anthrone colorimetry, and glycerol kinase chromogenic method, respectively. Additionally, amino acids were determined using cation exchange chromatography. The study revealed that wheat seedlings had lower water content than rape leaves. Although the crude protein content was comparable, the soluble carbohydrates of wheat seedlings were approximately 2.5 times higher than those of rape leaves. The body weight (fresh weight and dry weight), crude protein and triglyceride of locusts significantly increased when fed wheat seedlings compared with when fed rape leaves, with values of 48.08%, 31.58%, 43.83% and 25.00%, respectively. The high water content of rape leaves resulted in the high water content of rape leaf-fed locusts. Plants also affect the amino acid composition of locusts. The eight amino acids (four essential amino acids and four non-essential amino acids) and the total amino acids of rape leaf-fed locusts were significantly enhanced compared with those of wheat seedlings. The essential amino acid index and biological value indicate that the protein quality of locusts fed rape leaves has been significantly improved. These results demonstrate that the nutritional composition of L. migratoria can be altered by manipulating the diet. Insects with controllable nutrients can be provided by insect farms and further studies will improve the development of insects as food or feed.
Epilogue: Asia as a Privileged Space of Inquiry in the Field of Islamic Studies
Authors: Meyer Verena 
Published: April 2024

Abstract
Looking back at the articles collected in this issue, I want to propose that Asia is a privileged space for Islamic studies for addressing three questions in particular that are relevant for the wider discipline and demand a radical rethinking of familiar understandings of Islam as it has come to be represented in contemporary scholarship. First, the highly heterogeneous landscapes of Islamic Asia invite us to consider the significance of cultural, linguistic, and religious complexity in Islam more broadly. Second, while exhibiting the fundamental changes that Asian Muslims have navigated against the background of the increasing reach of colonialism and globalization, the preceding articles simultaneously resist easy dichotomizations between tradition and modernity. And third, a focus on Islam in Asia allows us to reassess established paradigms of transmission with its various infrastructures, as well as understandings of centers and peripheries undergirding such processes of transmission.
Critical Effects of Precipitation on Future Colorado River Flow
Authors: Hoerling Martin P. , Eischeid Jon K. , Diaz Henry F. , Rajagopolan Balaji , Kuhn Eric 
Published: April 2024

Abstract
Of concern to Colorado River management, as operating guidelines post-2026 are being considered, is whether water resource recovery from low flows during 2000–20 is possible. Here, we analyze new simulations from phase 6 of the Coupled Model Intercomparison Project (CMIP6) to determine plausible climate impacts on Colorado River flows for 2026–50 when revised guidelines would operate. We constrain projected flows for Lees Ferry, the gauge through which 85% of the river flow passes, using its estimated sensitivity to meteorological variability together with CMIP6-projected precipitation and temperature changes. The critical importance of precipitation, especially its natural variability, is emphasized. Model projections indicate increased precipitation in the upper Colorado River basin due to climate change, which alone increases river flows by 5%–7% (relative to a 2000–20 climatology). Depending on the river’s temperature sensitivity, this wet signal compensates for some, if not all, of the depleting effects of basin warming. Considerable internal decadal precipitation variability (∼5% of the climatological mean) is demonstrated, driving a greater range of plausible Colorado River flow changes for 2026–50 than previously surmised from treatment of temperature impacts alone: the overall precipitation-induced Lees Ferry flow changes span from −25% to +40%, contrasting with a range from −30% to −5% from expected warming effects only. Consequently, extreme low and high flows are more likely. Lees Ferry flow projections, conditioned on initial drought states akin to 2000–20, reveal substantial recovery odds for water resources, albeit with elevated risks of even further flow declines than in recent decades.

Significance Statement
Increasing temperatures have led to concerns that Colorado River flows will be permanently reduced due to global warming. Here, we analyze precipitation, surface temperature, and streamflow (at Lees Ferry) in the upper Colorado River basin since 1895 revealing precipitation to be the largest contributor to runoff variability while temperature variability has been a much smaller contributor. New climate model projections indicate increased precipitation in the upper basin due to global warming, acting to increase river flows by 5%–7% during 2026–50. This wet signal compensates for some of the depleting effects from further basinwide warming. Critically, the large intrinsic variability in precipitation is demonstrated to yield a wider range of future Colorado River flows than previously foreseen based solely on considering temperature effects.
On the Role of the Meridional Jet and Horizontal Potential Vorticity Dipole in the Iowa Derecho of 10 August 2020
Authors: Hitchman Matthew H. , Rowe Shellie M. 
Published: April 2024

Abstract
On 10 August 2020, a derecho caused widespread damage across Iowa and Illinois. Des Moines station data show that the arrival of the gust front was characterized by an abrupt shift to northerly flow, exceeding 22 m s−1 for ∼20 min. To test the hypothesis that this northerly jet is associated with a horizontal potential vorticity (PV) dipole in the lower troposphere, we investigated the structure of PV in the University of Wisconsin Nonhydrostatic Modeling System (UWNMS) and of absolute vorticity in High-Resolution Rapid Refresh (HRRR) forecast analyses. This structure is described here for the first time. The negative PV member coincides with the downdraft, while the positive PV member coincides with the updraft, with a northerly jet between. The westerly inflow jet descends anticyclonically in the downdraft, joining with northerly flow from the surface anticyclone. The resulting northerly outflow jet creates the trailing comma-shaped radar echo. The speed of propagation of the derecho is similar to the westerly wind maximum in the 3–5-km layer associated with the approaching synoptic cyclone, which acts as a steering level for resonant amplification. Idealized diagrams and 3D isosurfaces illustrate the commonality of the PV dipole/northerly jet structure. Differences in this structure among the three model states are related to low-level wind shear theory. The PV dipole coincides with the pattern of diabatic stretching tendency, which shifts westward and downward relative to the updraft/downdraft with increasing tilt. The PV dipole can contribute toward dynamical stability in a derecho.

Significance Statement
The purpose of this work is to investigate the structure of potential vorticity (PV) in the lower troposphere in a derecho. It is found that a northerly outflow jet occurs between an east–west-oriented horizontal PV dipole, which is described here for the first time. The negative PV member coincides with the downdraft and is inertially unstable, while the positive PV member coincides with the updraft. This work contributes toward the theory of resonant structures and longevity. The 3–5-km westerly inflow layer constitutes a steering level, which controls propagation speed despite differences in structure. The degree of westward tilt with height is related to the pattern of forcing by diabatic stretching in producing the PV dipole.
The Beneficial Effects of Topical Cream Containing 17% of Herbal Extract on Skin Barrier Function: A Randomized Four-week Trial
Authors: Lyu Ji-Hyo , Kim Soyeon , Kwon Kang , Kim Yongkuk , Choi Chanhun , Jeong Hyunwoo , Kim Hyungwoo 
Published: April 2024

Background Skin moisture management is important for maintaining healthy skin and treating inflammatory skin diseases, and skin barrier function can be assessed by measuring trans-epidermal water loss (TEWL) and skin moisture content. Aim This study was designed to investigate the effects of a topical cream containing 17% herbal extract (Cream17) on skin barrier function. Materials and Methods In this study, the ability of investigational product (IP) to improve skin barrier function was investigated in 33 subjects using a randomized and assessor-blinded four-week clinical trial. In our study, the effects of IP on TEWL, skin water content, and the degree of itching were investigated. Results After four weeks of application, TEWL was significantly reduced by IP ( p < 0.001), and skin water content was significantly increased ( p < 0.001) compared to non-treated control. In addition, topical application of IP significantly lowered the visual analog scale at the second and fourth weeks after treatment commencement as compared with those in the untreated control group (visit 3 at the second week, p < 0.05; visit 4 at the fourth week, p < 0.001). Conclusion These results indicate that Cream17 can improve the skin barrier function, which is important for managing dry skin conditions such as atopic dermatitis.
Feasibility Study of an Assistive Garment for Providing Kangaroo Mother Care to Preterm Neonates
Authors: Murry Lumchio Levis , Gupta Sanjay , Agarwal Ramesh , Sankar Jeeva , Gupta Deepti 
Published: April 2024

Objective of the study: This study was undertaken to test the feasibility and acceptability of an assistive garment for providing Kangaroo mother care (KMC) among mothers of preterm neonates. Study design: An interventional case series design was planned and eight mothers and their babies were recruited using convenience sampling. Feasibility outcomes were assessed using a validated log sheet. Acceptability outcomes were collected by a five-point attitude scale, from the mothers. Results: The garment supported the baby’s weight and maintained the position of the baby during KMC in all the sessions. Six mothers could express breast milk using a breast pump while using the garment. Most of the mothers voiced positive opinions about the garment.
Acalabrutinib-based regimens in frontline or relapsed/refractory higher-risk CLL: pooled analysis of 5 clinical trials
Authors: Davids Matthew S. , Sharman Jeff P. , Ghia Paolo , Woyach Jennifer A. , Eyre Toby A. , Jurczak Wojciech , Siddiqi Tanya , Miranda Paulo , Shahkarami Mina , Butturini Anna , Emeribe Ugochinyere , Byrd John C. 
Published: April 2024

Abstract
Before targeted therapies, patients with higher-risk chronic lymphocytic leukemia (CLL), defined as del(17p) and/or TP53 mutation (TP53m), unmutated immunoglobulin heavy chain variable region genes (uIGHV), or complex karyotype (CK), had poorer prognosis with chemoimmunotherapy. Bruton tyrosine kinase inhibitors (BTKis) have demonstrated benefit in higher-risk patient populations with CLL in individual trials. To better understand the impact of the second-generation BTKi acalabrutinib, we pooled data from 5 prospective clinical studies of acalabrutinib as monotherapy or in combination with obinutuzumab (ACE-CL-001, ACE-CL-003, ELEVATE-TN, ELEVATE-RR, and ASCEND) in patients with higher-risk CLL in treatment-naive (TN) or relapsed/refractory (R/R) cohorts. A total of 808 patients were included (TN cohort, n = 320; R/R cohort, n = 488). Median follow-up was 59.1 months (TN cohort) and 44.3 months (R/R cohort); 51.3% and 26.8% of patients in the TN and R/R cohorts, respectively, remained on treatment at last follow-up. In the del(17p)/TP53m, uIGHV, and CK subgroups in the TN cohort, median progression-free survival (PFS) and median overall survival (OS) were not reached (NR). In the del(17p)/TP53m, uIGHV, and CK subgroups in the R/R cohort, median PFS was 38.6 months, 46.9 months, and 38.6 months, respectively, and median OS was 60.6 months, NR, and NR, respectively. The safety profile of acalabrutinib-based therapy in this population was consistent with the known safety profile of acalabrutinib in a broad CLL population. Our analysis demonstrates long-term benefit of acalabrutinib-based regimens in patients with higher-risk CLL, regardless of line of therapy.
Lysosomal degradation targets mutant calreticulin and the thrombopoietin receptor in myeloproliferative neoplasms
Authors: Kaur Amanpreet , Venkatesan Arunkumar , Kandarpa Malathi , Talpaz Moshe , Raghavan Malini 
Published: April 2024

Abstract
Somatic mutants of calreticulin (CRT) drive myeloproliferative neoplasms (MPNs) via binding to the thrombopoietin receptor (MPL) and aberrant activation of the JAK/STAT pathway. Compared with healthy donors, platelets from mutant CRT-expressing patients with MPN display low cell surface MPL. Additionally, coexpression of MPL with an MPN-linked CRT mutant (CRTDel52) reduces cell surface MPL, suggesting that CRTDel52 may induce MPL degradation. We show that lysosomal degradation is relevant to the turnover of CRTDel52 and MPL. Furthermore, CRTDel52 increases the lysosomal localization and degradation of MPL. Mammalian target of rapamycin (mTOR) inhibitors reduce cellular CRTDel52 and MPL, secreted CRTDel52 levels, and impair CRTDel52–mediated cell proliferation. mTOR inhibition also reduces colony formation and differentiation of CD34+ cells from patients with MPN but not from healthy donors. Together, these findings indicate that low-surface MPL is a biomarker of mutant CRT-mediated MPN and that induced degradation of CRTDel52 and MPL is an avenue for therapeutic intervention.
HLA reduction of human T cells facilitates generation of immunologically multicompatible cellular products
Authors: Winterhalter Pascal M. , Warmuth Linda , Hilgendorf Philipp , Schütz Julius M. , Dötsch Sarah , Tonn Torsten , Cicin-Sain Luka , Busch Dirk H. , Schober Kilian 
Published: April 2024

Abstract
Adoptive cellular therapies have shown enormous potential but are complicated by personalization. Because of HLA mismatch, rejection of transferred T cells frequently occurs, compromising the T-cell graft's functionality. This obstacle has led to the development of HLA knock-out (KO) T cells as universal donor cells. Whether such editing directly affects T-cell functionality remains poorly understood. In addition, HLA KO T cells are susceptible to missing self-recognition through natural killer (NK) cells and lack of canonical HLA class I expression may represent a safety hazard. Engineering of noncanonical HLA molecules could counteract NK-cell recognition, but further complicates the generation of cell products. Here, we show that HLA KO does not alter T-cell functionality in vitro and in vivo. Although HLA KO abrogates allogeneic T-cell responses, it elicits NK-cell recognition. To circumvent this problem, we demonstrate that selective editing of individual HLA class I molecules in primary human T cells is possible. Such HLA reduction not only inhibits T-cell alloreactivity and NK-cell recognition simultaneously, but also preserves the T-cell graft's canonical HLA class I expression. In the presence of allogeneic T cells and NK cells, T cells with remaining expression of a single, matched HLA class I allele show improved functionality in vivo in comparison with conventional allogeneic T cells. Since reduction to only a few, most frequent HLA haplotypes would already be compatible with large shares of patient populations, this approach significantly extends the toolbox to generate broadly applicable cellular products.
Recipient clonal hematopoiesis in allogeneic bone marrow transplantation for lymphoid malignancies
Authors: Imus Philip H. , Pasca Sergiu , Tsai Hua-Ling , Aljawai Yosra M. , Cooke Kenneth R. , Walston Jeremy D. , Gocke Christopher D. , Varadhan Ravi , Jones Richard J. , Gondek Lukasz P. 
Published: April 2024

Abstract
Allogeneic blood and marrow transplantation (alloBMT) is increasingly being used in older patients with blood cancer. Aging is associated with an increasing incidence of clonal hematopoiesis (CH). Although the effects of donor CH on alloBMT has been reported, the impact of recipient CH on alloBMT outcomes is unknown. In this retrospective study, alloBMT recipients age 60 and older with lymphoid malignancies were included. Among 97 consecutive patients who received alloBMT between 2017 and 2022, CH was detected in 60 (62%; 95% confidence interval [CI], 51-72). CH was found in 45% (95% CI, 28-64) of patients aged 60 to 64, 64% (95% CI, 44-81) of patients aged 65% to 69%, and 73% (95% CI, 59-87) in those above 70. Pretransplant CH was associated with worse survival after alloBMT: 3-year overall survival (OS) was 78% (95% CI, 65-94) for patients without CH vs 47% (95% CI, 35-63) for those with CH, (unadjusted HR, 3.1; [95% CI, 1.4-6.8; P &lt; .001]). Nonrelapse mortality (NRM) was higher in patients with CH; cumulative incidence of NRM at 1-year was 11% (95% CI, 1-22) vs 35% (95% CI, 23-48), (HR, 3.4; [95% CI, 1.4-8.5], P = .009]). Among CH patients, worse OS and NRM was associated with CH burden and number of mutations. Recipient CH had no effect on relapse. In conclusion, older patients with CH experience worse outcomes after alloBMT, almost exclusively attributable to increased NRM. CH is a strong, independent predictor of outcomes. Novel strategies to ameliorate the adverse impacts of patient CH on transplant outcomes are being evaluated.
Final phase 1 substudy results of ivosidenib for patients with mutant IDH1 relapsed/refractory myelodysplastic syndrome
Authors: DiNardo Courtney D. , Roboz Gail J. , Watts Justin M. , Madanat Yazan F. , Prince Gabrielle T. , Baratam Praneeth , de Botton Stéphane , Stein Anthony , Foran James M. , Arellano Martha L. , Sallman David A. , Hossain Mohammad , Marchione Dylan M. , Bai Xiaofei , Patel Prapti A. , Kapsalis Stephanie M. , Garcia-Manero Guillermo , Fathi Amir T. 
Published: April 2024

Abstract
Ivosidenib is a first-in-class mutant isocitrate dehydrogenase 1 (mIDH1) inhibitor with efficacy and tolerability in patients with advanced mIDH1 hematologic malignancies, leading to approval in frontline and relapsed/refractory (R/R) mIDH1 acute myeloid leukemia. We report final data from a phase 1 single-arm substudy of once-daily ivosidenib in patients with R/R mIDH1 myelodysplastic syndrome (MDS) after failure of standard-of-care therapies. Primary objectives were to determine safety, tolerability, and clinical activity. The primary efficacy end point was the complete remission (CR) + partial remission (PR) rate. Nineteen patients were enrolled; 18 were included in the efficacy analysis. Treatment-related adverse events occurred in 8 (42.1%) patients, including a grade 1 QT interval prolongation in 1 (5.3%) patient and grade 2 differentiation syndrome in 2 (10.5%) patients. Rates of CR + PR and objective response (CR + PR + marrow CR) were 38.9% (95% confidence interval [CI], 17.3-64.3) and 83.3% (95% CI, 58.6-96.4), respectively. Kaplan-Meier estimates showed a 68.6% probability of patients in CR achieving a remission duration of ≥5 years, and a median overall survival of 35.7 months. Of note, 71.4% and 75.0% baseline red blood cell (RBC)- and platelet-transfusion-dependent patients, respectively, became transfusion independent (TI; no transfusion for ≥56 days); 81.8% and 100% of baseline RBC and platelet TI patients, respectively, remained TI. One (5.3%) patient proceeded to a hematopoietic stem cell transplant. In conclusion, ivosidenib is clinically active, with durable remissions and a manageable safety profile observed in these patients. This trial was registered at www.ClinicalTrials.gov as #NCT02074839.
Rates of severe neutropenia and infection risk in patients treated with deferiprone: 28 years of data
Authors: Badawy Sherif M. , Palmblad Jan , Tricta Fernando , Toiber Temin Noemi , Fradette Caroline , Lin Leo , Rozova Anna , Sheth Sujit 
Published: April 2024

Abstract
Patients treated with deferiprone for transfusional iron overload may experience idiosyncratic drug–induced neutropenia (IDIN) that may increase risk of infection. This analysis examined the rates of severe IDIN and risk of serious infections at different absolute neutrophil count (ANC) levels during deferiprone treatment. Events of severe IDIN (ANC &lt;0.5 × 109/L) and associated serious infections from clinical trials and postmarketing setting were analyzed by discrete ANC levels: group 1, 0.2 × 109/L to 0.5 × 109/L; group 2, 0.1 × 109/L to 0.199 × 109/L; group 3, &lt;0.1 × 109/L. In clinical trials, 22 events of severe IDIN occurred (group 1, n = 9; group 2, n = 3; group 3, n = 10), and rates of severe IDIN per 100 patient-years were 0.45 in group 1; 0.15 in group 2; and 0.50 in group 3 (1990.26 patient-years deferiprone exposure). All serious infections were in group 3 (3/10 [30.0%]). In the postmarketing setting, 176 events of severe IDIN were reported (group 1, n = 65; group 2, n = 20; group 3, n = 91) and rates of severe IDIN per 100 patient-years were 0.06 in group 1; 0.02 in group 2; and 0.08 in group 3 (111 570.24 patient-years deferiprone exposure). Rates of serious infection were 7.7% (5/65) in group 1; 10% (2/20) in group 2; and 13.2% (12/91) in group 3. Our findings suggest a high risk of serious infections with ANC &lt;0.2 × 109/L during deferiprone treatment, a level consistent with the recent neutropenia guidelines.