bluuebunny/crossref_metadata_2025_split huggingface dataset:
Moral obligation, autonomous motivation and vaccine hesitancy: Highlighting moral obligation increases reactance in hesitant individuals
Authors: Pavey Louisa , Rotella Amanda , Vallée‐Tourangeau Gaelle 
Published: April 2024

AbstractVaccine hesitancy is widespread, and developing effective communication strategies that encourage hesitant individuals to choose vaccination is essential. This pre‐registered research aimed to examine associations among moral obligation, autonomous motivation, vaccination intentions and reactance, and to test messages highlighting moral obligation and autonomy support. In Study 1, participants who had not received a Covid‐19 vaccine (N = 1036) completed measures of autonomous motivation, moral obligation, reactance, intentions to vaccinate and vaccine hesitancy. Autonomous motivation and moral obligation emerged as strong independent predictors of lower reactance, lower hesitancy and greater vaccination intentions. In Study 2 (N = 429), the participants received a vaccination‐promoting message that highlighted moral obligation versus personal protection and used autonomy supportive versus controlling language. Messages with autonomy‐supportive language and highlighting personal protection elicited lower reactance and greater perceived legitimacy compared to messages with controlling language and highlighting moral obligation. All messages elicited greater reactance and lower perceived legitimacy compared to an information‐only message, and there were no effects of message type on vaccination intentions or vaccine hesitancy. The research has implications for the design of communications encouraging vaccination in hesitant individuals and suggests caution should be taken when developing messages to encourage vaccination in hesitant individuals.
Firing technology and physicochemical basis for porcelain from the Xing kiln in the late sixth century
Authors: Zong Ruofei , Lu Xiaoke , Li Weidong , Xu Changsong 
Published: April 2024

AbstractThe rise of porcelain industry in northern China and the subsequent emergence of white porcelain production during the Northern dynasties (386–581 CE) played a pivotal role in shaping the historical trajectory of Chinese ceramics. Xing kiln is one of China's earliest and most representative white porcelain kilns. Herein, we investigated 23 porcelain sherds from the Neiqiu Xing kiln site during the late Northern dynasties and the early Sui dynasty (550–600 CE) from the perspective of firing temperature, firing atmosphere, and microstructure using a dilatometer, X‐ray photoelectron spectroscopy, and scanning electron microscopy. The results show that the early Xing porcelains were fired at high firing temperatures exceeding 1200°C with a reducing flame, and the adjustment of temperature promotes the emergence of early white porcelain. Moreover, the higher firing temperature of early Xing porcelain leads to the dominance of a glassy phase within the glaze, and the high bonding strength of the glaze and body caused by the body–glaze interaction layer formed with dense anorthite crystals. Overall, these findings provide valuable insights into the firing technology in the Xing kiln and even in North China during the late sixth century.
Robot‐assisted intracorporeal ileal conduit urinary diversion: A two‐center comparative study of Bricker versus Wallace ureteroileal anastomosis
Authors: Kadoriku Fumiya , Sasaki Yutaro , Fukuta Kyotaro , Nishiyama Mitsuki , Utsunomiya Seiya , Kobayashi Saki , Shiozaki Keito , Daizumoto Kei , Ueno Yoshiteru , Seto Kosuke , Tomida Ryotaro , Kusuhara Yoshito , Fukawa Tomoya , Nakanishi Ryoichi , Yamaguchi Kunihisa , Yamamoto Yasuyo , Izaki Hirofumi , Takahashi Masayuki , Furukawa Junya 
Published: April 2024

AbstractIntroductionThis study was performed to evaluate the differences in the perioperative results, renal function, and incidence of hydronephrosis over time between the use of Bricker anastomosis and Wallace anastomosis for robot‐assisted intracorporeal ileal conduit urinary diversion (RICIC).MethodsFifty‐five patients who underwent RICIC at two institutions were evaluated (Bricker, n = 23; Wallace, n = 32). We investigated changes in estimated glomerular filtration rate and hydronephrosis before surgery and at 3, 6, and 12 months after surgery.ResultsThe patients in the Bricker group were significantly older than those in the Wallace group. The urinary diversion time was significantly longer in the Bricker group. No significant difference in postoperative renal function was observed. Additionally, no significant difference was observed in the incidence of postoperative hydronephrosis. However, the incidence of right hydronephrosis tended to be high overall, especially in the Wallace group. No patients in either group required repair surgery or ureteral stent placement.ConclusionsIn patients undergoing RICIC, there was no difference in postoperative renal function or the incidence of hydronephrosis between Wallace and Bricker anastomosis. Symptomatic hydronephrosis was not observed in either group. The present study showed that each method was equally effective and safe.
Exploring genital and pregenital musculature in Synthesiomyia nudiseta (Diptera: Muscidae: Reinwardtiinae): Insights into evolutionary relationships with subfamily Azeliinae
Authors: Ovtshinnikova O. G. , Ivorra T. , Sorokina V. S. 
Published: April 2024

AbstractThe male genital, pregenital skeleton, musculature of male terminalia, and the ovipositor were studied in Synthesiomyia nudiseta (Wulp). A comparison was conducted between the terminal segments and muscles of S. nudiseta and previously studied species of the subfamily Azeliinae. Notable differences were found between previously studied species of the subfamily Azeliinae and Synthesiomyia + Muscina. These differences correspond to apomorphic character states in Synthesiomyia + Muscina, including the large size of the ejaculatory apodeme and the powerful constrictors of the ejaculatory apodeme M 23; the completely membranous sternite VI; the membrane connection of the muscle ISM 5 (lower); the small size of pregonites and postgonites; and the joints of the phallapodeme muscles М 21 at the base of the hypandrial arms. Based on these differences, Synthesiomyia + Muscina can be assigned to the subfamily Reinwardtiinae, as has been confirmed by recent molecular studies. However, similarities in the set of pregenital muscles and the set of phallapodeme muscles between Synthesiomyia + Muscina and the Azeliinae were also noted. These similarities may be considered as plesiomorphic character states, indicating their phylogenetic relationship. It can be argued that Reinwardtiinae + Azeliinae constitute sister groups and occupy the basal position within the family Muscidae.
Adding the epigenomic signature to the prognostic jigsaw of myelodysplastic neoplasm?
Authors: Gill Harinder 
Published: April 2024

Defining mechanisms of resistance to hypomethylating agents (HMAs) and biomarkers predictive of treatment response remains challenging in myelodysplastic neoplasm (MDS). Currently available prognostic tools that predict overall survival and transformation to acute myeloid leukaemia have not been powered to predict responses to HMAs. Noguera‐Castells et al. comprehensively characterized the epigenomic profile in patients with MDS treated with azacitidine and described a methylation signature‐based prognostic tool in predicting responses to azacitidine.Commentary on: Noguera‐Castells et al. DNA methylation profiling of myelodysplastic syndromes and clinical response to azacitidine: a multicentre retrospective study. Br J Haematol 2024;204:1838‐1843.
Phylogenetic analysis of viviparity, matrotrophy, and other reproductive patterns in chondrichthyan fishes
Authors: Blackburn Daniel G. , Hughes Daniel F. 
Published: April 2024

ABSTRACTThe reproductive diversity of extant cartilaginous fishes (class Chondrichthyes) is extraordinarily broad, reflecting more than 400 million years of evolutionary history. Among their many notable reproductive specialisations are viviparity (live‐bearing reproduction) and matrotrophy (maternal provision of nutrients during gestation). However, attempts to understand the evolution of these traits have yielded highly discrepant conclusions. Here, we compile and analyse the current knowledge on the evolution of reproductive diversity in Chondrichthyes with particular foci on the frequency, phylogenetic distribution, and directionality of evolutionary changes in their modes of reproduction. To characterise the evolutionary transformations, we amassed the largest empirical data set of reproductive parameters to date covering nearly 800 extant species and analysed it via a comprehensive molecular‐based phylogeny. Our phylogenetic reconstructions indicated that the ancestral pattern for Chondrichthyes is ‘short single oviparity’ (as found in extant holocephalans) in which females lay successive clutches (broods) of one or two eggs. Viviparity has originated at least 12 times, with 10 origins among sharks, one in batoids, and (based on published evidence) another potential origin in a fossil holocephalan. Substantial matrotrophy has evolved at least six times, including one origin of placentotrophy, three separate origins of oophagy (egg ingestion), and two origins of histotrophy (uptake of uterine secretions). In two clades, placentation was replaced by histotrophy. Unlike past reconstructions, our analysis reveals no evidence that viviparity has ever reverted to oviparity in this group. Both viviparity and matrotrophy have arisen by a variety of evolutionary sequences. In addition, the ancestral pattern of oviparity has given rise to three distinct egg‐laying patterns that increased clutch (brood) size and/or involved deposition of eggs at advanced stages of development. Geologically, the ancestral oviparous pattern arose in the Paleozoic. Most origins of viviparity and matrotrophy date to the Mesozoic, while a few that are represented at low taxonomic levels are of Cenozoic origin. Coupled with other recent work, this review points the way towards an emerging consensus on reproductive evolution in chondrichthyans while offering a basis for future functional and evolutionary analyses. This review also contributes to conservation efforts by highlighting taxa whose reproductive specialisations reflect distinctive evolutionary trajectories and that deserve special protection and further investigation.
Possible incomplete penetrance of Xq28 int22h‐1/int22h‐2 duplication
Authors: Billes Alexis , Pujalte Mathilde , Jedraszak Guillaume , Amsallem Daniel , Boudry‐Labis Elise , Boute Odile , Bouquillon Sonia , Brischoux‐Boucher Elise , Callier Patrick , Coutton Charles , Denizet Anne‐Laude Avice , Dieterich Klaus , Kuentz Paul , Lespinasse James , Mazel Benoît , Morin Gilles , Amram Florence , Pennamen Perrine , Rio Marlène , Piard Juliette , Putoux Audrey , Rama Mélanie , Roze‐Guillaumey Virginie , Schluth‐Bolard Caroline , Till Marianne , Trouvé Chloé , Vieville Gaëlle , Rooryck Caroline , Sanlaville Damien , Chatron Nicolas 
Published: April 2024

AbstractXq28 int22h‐1/int22h‐2 duplication is the result of non‐allelic homologous recombination between int22h‐1/int22h‐2 repeats separated by 0.5 Mb. It is responsible for a syndromic form of intellectual disability (ID), with recurrent infections and atopic diseases. Minor defects, nonspecific facial dysmorphic features, and overweight have also been described. Half of female carriers have been reported with ID, whereas all reported evaluated born males present mild to moderate ID, suggesting complete penetrance. We collected data on 15 families from eight university hospitals. Among them, 40 patients, 21 females (one fetus), and 19 males (two fetuses), were carriers of typical or atypical Xq28 int22h‐1/int22h‐2 duplication. Twenty‐one individuals were considered asymptomatic (16 females and 5 males), without significantly higher rate of recurrent infections, atopia, overweight, or facial dysmorphism. Approximately 67% live‐born males and 23% live‐born female carriers of the typical duplication did not have obvious signs of intellectual disability, suggesting previously undescribed incomplete penetrance or low expression in certain carriers. The possibility of a second‐hit or modifying factors to this possible susceptibility locus is yet to be studied but a possible observational bias should be considered in assessing such challenging X‐chromosome copy number gains. Additional segregation studies should help to quantify this newly described incomplete penetrance.
Effects of plant taxonomic position on soil nematode communities in Antarctica
Authors: Zhang Anning , Song Hongxian , Liu Ziyang , Cui Hanwen , Ding Haitao , Chen Shuyan , Xiao Sa , An Lizhe , Cardoso Pedro 
Published: April 2024

AbstractAntarctica terrestrial ecosystems are facing the most threats from global climate change, which is altering plant composition greatly. These transformations may cause major reshuffling of soil community composition, including functional traits and diversity, and therefore affect ecosystem processes in Antarctica. We used high‐throughput sequencing analysis to investigate soil nematodes under 3 dominant plant functional groups (lichens, mosses, and vascular plants) and bare ground in the Antarctic region. We calculated functional diversity of nematodes based on their diet, life histories, and body mass with kernel density n‐dimensional hypervolumes. We also calculated taxonomic and functional beta diversity of the nematode communities based on Jaccard dissimilarity. The presence of plants had no significant effect on the taxonomic richness of nematodes but significantly increased nematode functional richness. The presence of plants also significantly decreased taxonomic beta diversity (homogenization). Only mosses and vascular plants decreased nematode functional beta diversity, which was mostly due to a decreased effect of the richness difference component. The presence of plants also increased the effect of deterministic processes potentially because environmental filtering created conditions favorable to nematodes at low trophic levels with short life histories and small body size. Increasing plant cover in the Antarctic due to climate change may lead to increased diversity of nematode species that can use the scarce resources and nematode taxonomic and functional homogenization. In a future under climate change, community restructuring in the region is possible.
Pharmacokinetics, pharmacodynamics, and safety of fesomersen, a novel antisense inhibitor of factor XI, in healthy Chinese, Japanese, and Caucasian volunteers
Authors: Liu Tianxing , Hashizume Kensei , Krieg Eva , Chen Huijun , Mukaida Yuki , Thelen Kirstin , Friedrichs Frauke , Willmann Stefan , Schwers Stephan , Solms Alexander , Yu Rosie 
Published: April 2024

AbstractThe inhibition of coagulation factor XI (FXI) presents an attractive approach for anticoagulation as it is not expected to increase the risk of clinically relevant bleeding and is anticipated to be at least as effective as currently available anticoagulants. Fesomersen is a conjugated antisense oligonucleotide that selectively inhibits the expression of FXI. The article describes three clinical studies that investigated the safety, pharmacokinetic (PK), and pharmacodynamic (PD) profiles of fesomersen after subcutaneous (s.c.) injection to healthy participants. The studies included participants from diverse ethnic backgrounds (Caucasian, Japanese, and Chinese). Fesomersen demonstrated good safety and tolerability in all three studies. No major bleeding events were observed. After single‐dose s.c. injection, fesomersen was rapidly absorbed into the systemic circulation, with maximum fesomersen‐equivalent (fesomersen‐eq) concentrations (Cmax) in plasma observed within a few hours. After reaching Cmax, plasma fesomersen‐eq concentrations declined in a biphasic fashion. The PD analyses showed that the injection of fesomersen led to dose‐dependent reductions in FXI activity and increases in activated partial thromboplastin time (aPTT). The maximum observed PD effects were reached between Day 15 and 30, and FXI activity and aPTT returned to near‐baseline levels by Day 90 after a single dose. The PK/PD profiles after a single injection were similar among the various ethnic groups. Collectively, the study results suggest that fesomersen has a favorable safety profile and predictable and similar PK and PD profiles across Chinese, Japanese, and Caucasian participants.
Luther and the “Repair of Chalcedon”1
Authors: Hinlicky Paul R. 
Published: April 2024

AbstractLuther's Christology has long been suspected of deviating from the Chalcedonian Definition. Analysis of the suspicions raises in turn questions about Chalcedon as an incoherent compromise between the forces of Cyril and Leo. Complicating the issue is the metaphysical rendering of hypostasis as suppositum in medieval Western scholasticism. Luther's theopaschite Christology presses for the “repair” of Chalcedon by situating the Antiochene concern for Christ's human obedience within the divine self‐donation of the Eternal Son according to the Alexandrians. In a Trinitarian Christology incorporating the Antiochene concern for the human obedience of Christ, there would be no competition between the personal union of the divine Son in taking on human body and soul and the Holy Spirit anointing this assumed flesh to create of it the new Adam.
What climate litigation reveals about judicial competence
Authors: de Lange Douwe 
Published: April 2024

AbstractIn recent years, the US and the Netherlands have been on opposing sides of the spectrum regarding climate litigation. Dutch courts, in several revolutionary climate cases, have been an arena of societal change, whilst climate claims in the US have been largely unsuccessful. In a way this difference seems strange, because the US judiciary has the power of constitutional review, whilst the Dutch judiciary does not. Against that background, this paper extensively compares the doctrines of judicial competence regarding political questions in both jurisdictions. As a comparative framework, this paper uses three judicial phases, namely: the institutional phase, the substantial phase, and the remedial phase. Climate litigation reveals that the Dutch doctrine of judicial competence is focused on the substantial and remedial phases, which has allowed it more freedom in reviewing climate litigation. On the other hand, climate litigation reveals that the US doctrine of judicial competence is focused on a strict institutional phase, dominated by the Political Question Doctrine (PQD). The main contribution of this paper to the constitutional debate is that climate litigation reveals fundamental differences in doctrines of judicial competence. This is not only an important takeaway for future climate litigation, but also, in terms of the Radbruch formula, for other potential gaps between the executive and justice.
The effects of advanced glycation end‐products on skin and potential anti‐glycation strategies
Authors: Wang Lingyu , Jiang Yanfei , Zhao Chunyue 
Published: April 2024

AbstractThe advanced glycation end‐products (AGEs) are produced through non‐enzymatic glycation between reducing sugars and free amino groups, such as proteins, lipids or nucleic acids. AGEs can enter the body through daily dietary intake and can also be generated internally via normal metabolism and external stimuli. AGEs bind to cell surface receptors for AGEs, triggering oxidative stress and inflammation responses that lead to skin ageing and various diseases. Evidence shows that AGEs contribute to skin dysfunction and ageing. This review introduces the basic information, the sources, the metabolism and absorption of AGEs. We also summarise the detrimental mechanisms of AGEs to skin ageing and other chronic diseases. For the potential strategies for counteracting AGEs to skin and other organs, we summarised the pathways that could be utilised to resist glycation. Chemical and natural‐derived anti‐glycation approaches are overviewed. This work offers an understanding of AGEs to skin ageing and other chronic diseases and may provide perspectives for the development of anti‐glycation strategies.
Cloud‐based provenance framework for duplicates identification and data quality enhancement
Authors: Khan Fakhri Alam 
Published: April 2024

AbstractCloud computing revolutionizes data management by offering centralized repositories or services accessible over the Internet. These services, hosted by a single provider or distributed across multiple entities, facilitate seamless access for users and applications. Additionally, cloud technology enables federated search capabilities, allowing organizations to amalgamate data from diverse sources and perform comprehensive searches. However, such integration often leads to challenges in data quality and duplication due to structural disparities among datasets, including variations in metadata. This research presents a novel provenance‐based search model designed to enhance data quality within cloud environments. The model expands the traditional concept of a single canonical URL by incorporating provenance data, thus providing users with diverse search options. Leveraging this model, the study conducts inferential analyses to improve data accuracy and identify duplicate entries effectively. To verify the proposed model, two research paper datasets from Kaggle and DBLP repositories are utilized, and the model effectively identifies duplicates, even with partial queries. Tests demonstrate the system's ability to remove duplicates based on title or author, in both single and distributed dataset scenarios. Traditional search engines struggle with duplicate content, resulting in biased results or inefficient crawling. In contrast, this research uses provenance data to improve search capabilities, overcoming these limitations.
Uppermost global tree elevations are primarily limited by low temperature or insufficient moisture
Authors: Xie Yuyang , Shen Zehao , Wang Tao , Malanson George P. , Peñuelas Josep , Wang Xiaoyi , Chen Xiangwu , Liang Eryuan , Liu Hongyan , Yang Mingzheng , Ying Lingxiao , Zhao Fu , Piao Shilong 
Published: April 2024

AbstractThe impact of anthropogenic global warming has induced significant upward dispersal of trees to higher elevations at alpine treelines. Assessing vertical deviation from current uppermost tree distributions to potential treeline positions is crucial for understanding ecosystem responses to evolving global climate. However, due to data resolution constraints and research scale limitation, comprehending the global pattern of alpine treeline elevations and driving factors remains challenging. This study constructed a comprehensive quasi‐observational dataset of uppermost tree distribution across global mountains using Google Earth imagery. Validating the isotherm of mean growing‐season air temperature at 6.6 ± 0.3°C as the global indicator of thermal treeline, we found that around two‐thirds of uppermost tree distribution records significantly deviated from it. Drought conditions constitute the primary driver in 51% of cases, followed by mountain elevation effect which indicates surface heat (27%). Our analyses underscore the multifaceted determinants of global patterns of alpine treeline, explaining divergent treeline responses to climate warming. Moisture, along with temperature and disturbance, plays the most fundamental roles in understanding global variation of alpine treeline elevation and forecasting alpine treeline response to ongoing global warming.