bluuebunny/crossref_metadata_2025_split huggingface dataset:
The candidate proteins associated with keratoconus: A meta-analysis and bioinformatic analysis
Authors: Song Ting , Song Jie , Li Jingyi , Ben Hilal Halima , Li Xiaona , Feng Pengfei , Chen Weiyi 
Published: March 2024

PurposeKeratoconus (KC) is a multifactorial disorder. This study aimed to conduct a systematic meta-analysis to exclusively explore the candidate proteins associated with KC pathogenesis.MethodsRelevant literature published in the last ten years in Pubmed, Web of Science, Cochrane, and Embase databases were searched. Protein expression data were presented as the standard mean difference (SMD) and 95% confidence intervals (CI). The meta-analysis is registered on PROSPERO, registration number CRD42022332442 and was conducted in accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analyses statement (PRISMA). GO and KEGG enrichment analysis were performed, as well as the miRNAs and chemicals targeting the candidate proteins were predicted. PPI was analyzed to screen the hub proteins, and their expression was verified by RT-qPCR.ResultsA total of 21 studies were included in the meta-analysis, involving 346 normal eyes and 493 KC eyes. 18 deregulated proteins with significant SMD values were subjected to further analysis. In which, 7 proteins were up-regulated in KC compared with normal controls, including IL6 (SMD 1.54, 95%CI [0.85, 2.24]), IL1B (SMD 2.07, 95%CI [0.98, 3.16]), TNF (SMD 2.1, 95%CI [0.24, 3.96]), and MMP9 (SMD 1.96, 95%CI [0.68, 3.24]). While 11 proteins were down-regulated in KC including LOX (SMD 2.54, 95%CI [-4.51, -0.57]). GO and KEGG analysis showed that the deregulated proteins were involved in inflammation, extracellular matrix (ECM) remodeling, and apoptosis. MMP9, IL6, LOX, TNF, and IL1B were regarded as hub proteins according to the PPI analysis, and their transcription changes in stromal fibroblasts of KC were consistent with the results of the meta-analysis. Moreover, 10 miRNAs and two natural polyphenols interacting with hub proteins were identified.ConclusionThis study obtained 18 candidate proteins and demonstrated altered cytokine profiles, ECM remodeling, and apoptosis in KC patients through meta-analysis and bioinformatic analysis. It will provide biomarkers for further understanding of KC pathogenesis, and potential therapeutic targets for the drug treatment of KC.
The EvalUation of goal-diRected activities to prOmote well-beIng and heAlth (EUROIA) scale: Psychometric evaluation with Confirmatory Factor Analysis
Authors: Francis Troy , Peiris Rachel G. , Stanimirovic Aleksandra , Stogios Nicolette , Syed Fatima , Rac Valeria E. , Nolan Robert P. 
Published: March 2024

Objectives
While state-based models of health-related quality of life (HRQL) are well-established in providing clinically relevant descriptions of HRQL status, they do not provide information on how to maintain or improve HRQL. The EvalUation of goal-diRected activities to prOmote well-beIng and heAlth (EUROIA), rooted in a novel process-based model of HRQL, measures goal-directed activities that are self-reported to promote HRQL as part of an individual’s process of adapting to dynamic changes in health status. Our objectives were to condense and summarize the psychometric properties of the EUROIA by (i) defining and confirming its factor structure, (ii) evaluating its construct validity, and (iii) examining its internal consistency.

Methods
Principal component analysis was performed on the 18-item EUROIA to explore the underlying factor structure and condense the scale. Confirmatory factor analysis was conducted on the revised 14-item, 4-factor structure EUROIA instrument to evaluate the model fit. Data was obtained from adult participants with a diagnosis of chronic heart failure or advanced chronic kidney disease from 3 hospitals in Toronto, Canada.

Results
The revised 14-item EUROIA demonstrated 4 dimensions–Social Affiliation, fulfillment of Social Roles and Responsibilities, Self-Affirmation, and Eudaimonic Well-being–with a Cronbach’s alpha of 0.83, representing good internal consistency. Our confirmatory factor analysis final model achieved good overall model fit: (χ2 / df = 1.80; Tucker-Lewis index = 0.90; comparative fit index = 0.93; standardized root-mean-square residual = 0.06; root-mean-square error of approximation = 0.06). All items exhibited a factor loading greater than λ > 0.4 and p < 0.001.

Conclusion
The EUROIA holds clinical potential in its ability to provide informed feedback to patients on how they might maintain or modify their use of goal-directed activities to maintain and optimize perceived well-being.
Artificial intelligence of imaging and clinical neurological data for predictive, preventive and personalized (P3) medicine for Parkinson Disease: The NeuroArtP3 protocol for a multi-center research study
Authors: Malaguti Maria Chiara , Gios Lorenzo , Giometto Bruno , Longo Chiara , Riello Marianna , Ottaviani Donatella , Pellegrini Maria , Di Giacopo Raffaella , Donner Davide , Rozzanigo Umberto , Chierici Marco , Moroni Monica , Jurman Giuseppe , Bincoletto Giorgia , Pardini Matteo , Bacchin Ruggero , Nobili Flavio , Di Biasio Francesca , Avanzino Laura , Marchese Roberta , Mandich Paola , Garbarino Sara , Pagano Mattia , Campi Cristina , Piana Michele , Marenco Manuela , Uccelli Antonio , Osmani Venet 
Published: March 2024

Background
The burden of Parkinson Disease (PD) represents a key public health issue and it is essential to develop innovative and cost-effective approaches to promote sustainable diagnostic and therapeutic interventions. In this perspective the adoption of a P3 (predictive, preventive and personalized) medicine approach seems to be pivotal. The NeuroArtP3 (NET-2018-12366666) is a four-year multi-site project co-funded by the Italian Ministry of Health, bringing together clinical and computational centers operating in the field of neurology, including PD.

Objective
The core objectives of the project are: i) to harmonize the collection of data across the participating centers, ii) to structure standardized disease-specific datasets and iii) to advance knowledge on disease’s trajectories through machine learning analysis.

Methods
The 4-years study combines two consecutive research components: i) a multi-center retrospective observational phase; ii) a multi-center prospective observational phase. The retrospective phase aims at collecting data of the patients admitted at the participating clinical centers. Whereas the prospective phase aims at collecting the same variables of the retrospective study in newly diagnosed patients who will be enrolled at the same centers.

Results
The participating clinical centers are the Provincial Health Services (APSS) of Trento (Italy) as the center responsible for the PD study and the IRCCS San Martino Hospital of Genoa (Italy) as the promoter center of the NeuroartP3 project. The computational centers responsible for data analysis are the Bruno Kessler Foundation of Trento (Italy) with TrentinoSalute4.0 –Competence Center for Digital Health of the Province of Trento (Italy) and the LISCOMPlab University of Genoa (Italy).

Conclusions
The work behind this observational study protocol shows how it is possible and viable to systematize data collection procedures in order to feed research and to advance the implementation of a P3 approach into the clinical practice through the use of AI models.
The therapeutic alliance between study participants and intervention facilitators is associated with acute effects and clinical outcomes in a psilocybin-assisted therapy trial for major depressive disorder
Authors: Levin Adam W. , Lancelotta Rafaelle , Sepeda Nathan D. , Gukasyan Natalie , Nayak Sandeep , Wagener Theodore L. , Barrett Frederick S. , Griffiths Roland R. , Davis Alan K. 
Published: March 2024

We examined if the therapeutic alliance between study participants and intervention facilitators in a psilocybin-assisted therapy (PAT) trial changed over time and whether there were relationships between alliance, acute psilocybin experiences, and depression outcomes. In a randomized, waiting list-controlled clinical trial for major depressive disorder in adults (N = 24), participants were randomized to an immediate (N = 13) or delayed (N = 11) condition with two oral doses of psilocybin (20mg/70kg and 30mg/70kg). Ratings of therapeutic alliance significantly increased from the final preparation session to one-week post-intervention (p = .03, d = .43). A stronger total alliance at the final preparation session predicted depression scores at 4 weeks (r = -.65, p = .002), 6 months (r = -.47, p = .036), and 12 months (r = -.54, p = .014) post-intervention. A stronger total alliance in the final preparation session was correlated with higher peak ratings of mystical experiences (r = .49, p = .027) and psychological insight (r = .52, p = .040), and peak ratings of mystical experience and psychological insight were correlated with depression scores at 4 weeks (r = -.45, p = .030 for mystical; r = -.75, p < .001 for insight). Stronger total alliance one week after the final psilocybin session predicted depression scores at 4 weeks (r = -.85, p < .001), 3 months (r = -.52, p = .010), 6 months (r = -.77, p < .001), and 12 months (r = -.61, p = .001) post-intervention. These findings highlight the importance of the therapeutic relationship in PAT. Future research should explore therapist and participant characteristics which maximize the therapeutic alliance and evaluate its relationship to treatment outcomes.
Trial registration: Registration: Clinicaltrials.gov NCT03181529. https://classic.clinicaltrials.gov/ct2/show/NCT03181529.
A Minority of Childhood Disorders of Gut-Brain Interaction Persist Into Adulthood: A Risk-Factor Analysis
Authors: Jones Michael P. , Koloski Natasha A. , Walker Marjorie M. , Holtmann Gerald J. , Shah Ayesha , Eslick Guy D. , Talley Nicholas J. 
Published: March 2024

INTRODUCTION:
Disorders of gut-brain interaction (DGBIs) may originate in childhood. There are currently limited data on persistence of DGBI into adulthood and risk factors for persistence. Furthermore, there are no data on this question from general practice, where the majority of DGBIs are diagnosed and managed. This study documents the proportion of childhood-diagnosed DGBIs that persisted into adulthood and what factors were associated with persistence.

METHODS:
General practice records were obtained for more than 60,000 patients whose medical record spanned both childhood and adulthood years. Patients with diagnosed organic gastrointestinal disorder were excluded. Medical records were also interrogated for potential risk factors.

RESULTS:
Eleven percent of patients with irritable bowel syndrome (IBS) and 20% of patients with functional dyspepsia (FD) diagnosed in childhood had repeat diagnoses of the same condition in adulthood. Female sex (odds ratio [OR] 2.02) was associated with persistence for IBS, while a childhood diagnosis of gastritis (OR 0.46) was risk-protective. Childhood non-steroidal anti-inflammatory drug use (OR 1.31, 95% confidence interval [CI] 1.09–1.56) was a risk factor for persistence in IBS. For FD, a childhood diagnosis of asthma (OR 1.30, 95% CI 1.00–1.70) was a risk factor, as was anxiety for both IBS (OR 1.24, 95% CI 1.00–1.54) and FD (OR 1.48 95% CI 1.11–1.97) with a similar finding for depression for IBS (OR 1.34, 95% CI 1.11–1.62) and FD (OR 1.88 95% CI 1.47–2.42).

DISCUSSION:
Childhood DGBIs persist into adulthood in 10%–20% of patients, suggesting that management monitoring should continue into adulthood. Those diagnosed with anxiety or mood disorders in childhood should receive particular attention, and prescription of non-steroidal anti-inflammatory drugs in children should be made judiciously.
Non-Hispanic Black Persons With Nonalcoholic Fatty Liver Disease Have Lower Rates of Advanced Fibrosis, Cirrhosis, and Liver-Related Events Even After Controlling for Clinical Risk Factors and PNPLA3 Genotype
Authors: Samala Niharika , Xin Yuchen , Wilson Laura A. , Yates Katherine , Loomba Rohit , Hoofnagle Jay H. , Chalasani Naga ,   for the NASH Clinical Research Network
Published: March 2024

INTRODUCTION:
Nonalcoholic fatty liver disease (NAFLD) is less frequent in non-Hispanic persons (NHB), but there are knowledge gaps in our understanding of disease severity and outcomes of NAFLD in NHB. We compared liver histology and clinical outcomes of NAFLD in non-Hispanic Black persons (NHB) and non-Hispanic White persons (NHW).

METHODS:
We compared liver histology and outcomes of 109 NHB and 1,910 NHW adults with biopsy-proven NAFLD participating in the Nonalcoholic Steatohepatitis Clinical Research Network observational studies. The relationship between self-reported NHB race/ethnicity and advanced fibrosis was assessed through multivariable logistic regression after controlling for clinical covariates and PNPLA3 genotype.

RESULTS:
NHB and NHW with NAFLD had similar NAFLD activity scores (NAS, 4.4 vs 4.3, P = 0.87) and proportions with definite metabolic dysfunction-associated steatohepatitis (59% vs 58%, P = 1.0), but NHB had significantly lower rates of advanced fibrosis (22% vs 34%, P = 0.01) or cirrhosis (4.6% vs 12.1%, P = 0.010). Compared with NHW, NHB had significantly lower frequency of advanced fibrosis (Odds Ratio: 0.48, 95% Confidence Interval: 27–0.86, P = 0.01). In a comparison between 24 NHB and 655 NHW with advanced fibrosis, the NAS (5.6 vs 4.9, P = 0.01) and lobular inflammation grade (2.2 vs 1.7, P < 0.002) were significantly higher among NHB with advanced fibrosis. One NHB and 23 NHW died during follow-up (0.30 vs 0.28 per 100 person-year follow-up). Seven and zero liver-related deaths occurred in NHW and NHB with NAFLD, respectively.

DISCUSSION:
The risk of advanced fibrosis in NHB with NAFLD is significantly lower, after controlling for clinical risk factors and PNPLA3 genotype. Although their risk of advanced fibrosis was low, NHB with NAFLD and advanced fibrosis had higher NAS and lobular inflammation, indicating a difference in their relationship between necroinflammation and fibrosis.
Effectiveness of Tofacitinib in Patients With Ulcerative Colitis: A Nationwide Veterans Administration Cohort Study
Authors: Khan Nabeel , Sundararajan Ramaswamy , Patel Manthankumar , Trivedi Chinmay , Yang Yu-Xiao 
Published: March 2024

INTRODUCTION:
There is paucity of data on the effectiveness and safety of tofacitinib among elderly patients with ulcerative colitis (UC).

METHODS:
Through a retrospective cohort study among the US National Veterans Affairs Healthcare System, we evaluated effectiveness among the elderly (≥65) and young (<65) patients with UC initiated on tofacitinib.

RESULTS:
Among 158 patients (53 elderly, 105 young), effectiveness at 12 months was 50.94% in the elderly and 33.33% in the young (P = 0.032).

DISCUSSION:
In a nationwide cohort of patients with UC initiating tofacitinib, effectiveness was seen in half of the elderly patients.
Analisis Total Padatan Tersuspensi (TSS) dan Nitrat (NO3-N), serta Penentuan Indeks Pencemaran di Perairan Pantai Rebo, Kabupaten Bangka
Authors: Aprilianti Wadiya , Yusuf Muh. , Wulandari Sri Yulina 
Published: March 2024

Kegiatan penambangan timah inkonvensional (TI) di perairan Pantai Rebo, Kabupaten Bangka menyebabkan tingginya Total Padatan Tersuspensi (TSS) dan juga diperkirakan mempengaruhi kandungan unsur hara nitrat di dalamnya. Penelitian ini bertujuan untuk mengetahui konsentrasi TSS dan kandungan nitrat (NO3-N), tingkat hubungan antar kedua parameter tersebut serta indeks pencemaran (IP). Sampel diambil dengan metode purposive sampling dengan memperhatikan lokasi dekat dan jauh dari area kegiatan penambangan. Uji konsentrasi TSS dilakukan dengan metode gravimetri dan uji konsentrasi nitrat dilakukan dengan metode reduksi kadmium. Hasil penelitian menunjukkan TSS berada pada kisaran 22,30 - 45,50 mg/L, sementara konsentrasi nitrat berada pada kisaran 0,046 - 0,144 mg/L. Semakin jauh dari sumber pencemaran, nilai TSS cenderung relatif rendah, sedangkan kandungan konsentrasi nitrat cenderung mengikuti penyebaran konsentrasi TSS. Hasil hitung IP dikategorikan sebagai tercemar sedang. Nilai R2 mengindikasikan pengaruh TSS secara simultan terhadap nitrat sebesar 52,22%. Sementara koefisien korelasi (r) dengan nilai 0,7226 mengindikasikan hubungan antar kedua parameter tersebut kuat.
,,Mystika" a „magie"
Authors: Horský Jan 
Published: March 2024

This report ls devoted both to the use of the term " mysticism" in the Czech historiography of the "Goll school" and the diffilculties encountered when applying social and cultural, and anthropological classification in historic work. Czech historians such as Vlastimil Kybal used the term "mysticism" in a meaning which is closer to the term "witchcraft" as used in sociological literature by Max Weber and current cultural anthropology. Kybal meant with "mysticism" associ­ation wilh God, incarnation in it, bul mediated through an act of sacrament and the subject matter of sacrament. This use differs from the work with the term "mysticism" as used, e.g., by Ernst Troeltsch. Vlastimil Kybal speaks about " mysticism" especially in connection wilh the demand of the frequent lay communion of altar sacrament as advocated by Jan Milíc z Kromeríze and Matej z Janova. The theme of frequent acceptation of altar sacrament is also a telling example of a diversity of cultural situations. lt enables, in fact, various "readings." There is, e. g., an interpretation stressing the "magic" features of frequent lay acceptation of altar sacrament (incarnation into Christ, mediated by sensually perceived entity). This interpretation may be supported by the findings of František Šmahel about popular culture in thc pre-Hussite era. At the same time, the demand of frequent lay sacrament can be interpreted in relation to its "ethical" importance (stress on the sacrament only being accepted by a man purged from sins and given by a "moral" priest). This interpretation is in keeping with an older way of reviewlng the importance of the Hussitism.
Vliv politické hranice na život obyvatelstva na moravsko-slovenském pomezí
Authors: Rychlíková Magdaléna 
Published: March 2024

Holíč is situated on the other side of the border river Morava ř km from Hodonín, an industrial town with population of 28 000. Before the split of Czechoslovakia in 1992 about one quarter of the working-able people of Holíč worked in Hodonín because there were more and better paid jobs. Hodonín was offering more opportunities for sport and cultural activities. There were also specialized secondary schools which did not exist in Holíč. Because there was no language barrier the pupils from Holíč could attend schools in Hodonín. All these possibilities were strictly limited after 1 January 1993, when two independent states - the Czech Republic and the Slovak Republic - came to existence. lt is true, that the border can be crossed al any place on lieu of the Identity card but this does not affect children under 15 years of age. Subsequently, the contacts of children from both towns is now limited. There is a special agreement allowing the citizens of one republic to work in the second one. Indeed, there is still a certain number of people from Holíč working in Hodonín, but to employ them means for an employer an extra paper work. Unemployment in Hodonín let to a decrease of number workers from Holíč to about 10 % pre-1993level. Public transport between Holíč and Hodonín was limited - there is now train connection only on working days, buses on weekends are only twice daily. Prices were increased and all discounts discontinued. Postal service is expensive and the mail goes via Brno and Bratislava which lakes from 5 to 8 days. Problems occured with transport of agricultural products and other items regardless that there is a custorns union between both republics. There are also problems connected with citizenship, pen­sions as well as health and social insurance.
Brain sodium sensing for regulation of thirst, salt appetite, and blood pressure
Authors: Hiyama Takeshi Y. 
Published: March 2024

AbstractThe brain possesses intricate mechanisms for monitoring sodium (Na) levels in body fluids. During prolonged dehydration, the brain detects variations in body fluids and produces sensations of thirst and aversions to salty tastes. At the core of these processes Nax, the brain's Na sensor, exists. Specialized neural nuclei, namely the subfornical organ (SFO) and organum vasculosum of the lamina terminalis (OVLT), which lack the blood–brain barrier, play pivotal roles. Within the glia enveloping the neurons in these regions, Nax collaborates with Na+/K+‐ATPase and glycolytic enzymes to drive glycolysis in response to elevated Na levels. Lactate released from these glia cells activates nearby inhibitory neurons. The SFO hosts distinct types of angiotensin II‐sensitive neurons encoding thirst and salt appetite, respectively. During dehydration, Nax‐activated inhibitory neurons suppress salt‐appetite neuron's activity, whereas salt deficiency reduces thirst neuron's activity through cholecystokinin. Prolonged dehydration increases the Na sensitivity of Nax via increased endothelin expression in the SFO. So far, patients with essential hypernatremia have been reported to lose thirst and antidiuretic hormone release due to Nax‐targeting autoantibodies. Inflammation in the SFO underlies the symptoms. Furthermore, Nax activation in the OVLT, driven by Na retention, stimulates the sympathetic nervous system via acid‐sensing ion channels, contributing to a blood pressure elevation.
Will COVID “encourage” B2B and data exchange engineering in logistic firms?
Authors: Šimek Libor , Cempírek Václav 
Published: March 2024

AbstractThe goal of this article is to develop recommendations to assist logistic companies in formulating their B2B deployment policies as part of their engineering infrastructure strategy. It is postulated that logistic firms are likely to integrate B2B into their organizational structure in order to obtain a competitive advantage. The research examines the situation not only in the period immediately prior (2006) and after (2010) the 2008–2009 economic crisis, but also over a longer period of the following years in order to discover an eventual impact of the crisis on B2B deployment (2014, 2018). The results obtained from the 2008–2009 economic crisis are then applied analogically to the current 2020 coronavirus economic recession, where they serve as a foundation for formulating B2B deployment policy recommendations. We ascertained that B2B deployment increases in time of intensified market competition due to an economic crisis or recession and this tendency persists even in a longer horizon after the macroeconomic instability culmination. B2B systems can thus act as a significant “tool” for enhancing business competitiveness, which may be crucial for their economic “survival.”