bluuebunny/crossref_metadata_2025_split huggingface dataset:
C—N Bond‐Linked Conjugates of Dibenz[b,f][1,4]oxazepines with 2‐Oxindole.
Authors: Xing Xinglong , Wu Jinlong , Luo Jialu , Dai Wei‐Min 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Highly Efficient Catalyst FeCl3 in the Synthesis of α‐Amino Phosphonates via Three‐Component Reactions.
Authors: Wu Jie , Sun Wei , Wang Wei‐Zi , Xia Hong‐Guang 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Regioselective Synthesis of Fluoroalkylated β‐Aminophosphorus Derivatives and Aziridines from Phosphorylated Oximes and Nucleophilic Reagents.
Authors: Palacios Francisco , Ochoa de Retana Ana M. , Alonso Jose M. 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
One‐Pot Synthesis of 2‐Imino‐1,3‐selenazolidines by Reaction of Isoselenocyanates with Propargylamine.
Authors: Koketsu Mamoru , Sakai Tsutomu , Kiyokuni Takashi , Garud Dinesh R. , Ando Hiromune , Ishihara Hideharu 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Total Synthesis of the Cytotoxic Guaipyridine Sesquiterpene Alkaloid (+)‐Cananodine.
Authors: Craig Donald , Henry Gavin D. 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Structure Elucidation of Fungal Sespendole (I), an Inhibitor of Lipid Droplet Synthesis in Macrophages.
Authors: Uchida Ryuji , Kim Yong‐Pil , Nagamitsu Tohru , Tomoda Hiroshi , Omura Satoshi 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
An Enantiospecific Synthesis of 2‐Pupukeanone.
Authors: Srikrishna A. , Kumar P. Ravi , Gharpure S. J. 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Ultrasound Accelerated Synthesis of Proteinogenic and α,α‐Dialkylamino Acid Ester Salts.
Authors: Kantharaju Kantharaju , Babu Vommina V. Suresh 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Triazolopeptides: Chirospecific Synthesis and cis/trans Prolyl Ratios of Structural Isomers.
Authors: Paul Andreas , Bittermann Holger , Gmeiner Peter 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Propargyl Glycosides as Stable Glycosyl Donors: Anomeric Activation and Glycoside Syntheses.
Authors: Hotha Srinivas , Kashyap Sudhir 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Novel Synthetic Route to α‐Galactosyl Ceramides and iGb3 Using DTBS‐Directed α‐Selective Galactosylation.
Authors: Kimura Akiyoshi , Imamura Akihiro , Ando Hiromune , Ishida Hideharu , Kiso Makoto 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Chaetoindicines A—C, Three Isoquinoline Alkaloids from the Fungus Chaetomium indicum.
Authors: Li Guo‐You , Li Bo‐Gang , Yang Tao , Liu Guang‐Ye , Zhang Guo‐Lin 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
First Total Synthesis of (.+‐.)‐Epocarbazolin A and Epocarbazolin B, and Asymmetric Synthesis of (‐)‐Epocarbazolin A via Shi Epoxidation.
Authors: Knoell Jan , Knoelker Hans‐Joachim 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Cell‐Adhesion Inhibitors Produced by a Sea Hare‐Derived Periconia sp. Part 2. Absolute Stereostructures of Peribysins H (I) and I (II).
Authors: Yamada Takeshi , Minoura Katsuhiko , Tanaka Reiko , Numata Atsushi 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Sr2TMO3 (TM: Ni, Co) Compounds with 1D TM—O Chains.
Authors: Kawasaki Masashi , et al. et al. 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Bacillus subtilis Assisted Assembly of Gold Nanoparticles into Long Conductive Nodous Ribbons.
Authors: He Yonghong , Yuan Jinying , Su Fengyi , Xing Xinhui , Shi Gaoquan 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Metallacarboranes of Main Group, Transition, and Lanthanoid Elements: Syntheses, Structures and Reactivities
Authors: Wang Jianhui , Maguire John A. , Hosmane Narayan S. 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Oxoanion Selectivity with Protonated Azacryptate Hosts — Influence of Hydration on Structure and Stability
Authors: Nelson J. , McKee V. , Town R. M. 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Methods for the Synthesis of Cannabinergic Ligands
Authors: Thakur Ganesh A. , Nikas Spyros P. , Duclos Jr. Richard I. , Makriyannis Alexandros 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
New Synthetic Methods of (Aza)n[3n]cyclophanes
Authors: Takemura Hiroyuki , Wen Gang , Shinmyozu Teruo 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Five‐Membered Ring Systems: Furans and Benzofurans
Authors: Hou Xue‐Long , Yang Zhen , Yeung Kap‐Sun , Wong Henry N. C. 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Clues to Dimetallohydrolase Mechanisms from Studies on Pyrazolate‐Based Bioinspired Dizinc Complexes — Experimental Evidence for a Functional Zn—O2H3—Zn Motif
Authors: Meyer Franc 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Prediction of Protein—Ligand Interactions. Docking and Scoring: Successes and Gaps
Authors: Leach Andrew R. , Shoichet Brian K. , Peishoff Catherine E. 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
The Remarkable Ability of B3LYP/3‐21G(*) Calculations to Describe Geometry, Spectral and Electrochemical Properties of Molecular and Supramolecular Porphyrin—Fullerene Conjugates
Authors: Zandler Melvin E. , D'Souza Francis 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Augmented suppression of androgen receptor signaling by a combination of α‐tocopheryl succinate and methylseleninic acid
Authors: Zhang Haitao , Wu Yue , Malewicz Barbara , Lu Junxuan , Li Song , Marshall James , Ip Clement , Dong Yan 
Published: November 2006

AbstractBACKGROUND.Previous reports showed that α‐tocopheryl succinate (αTS) and methylseleninic acid (MSA) independently reduce the abundance of androgen receptor (AR) in prostate cancer cells. The response to MSA happens quickly, whereas the response to αTS takes much longer. The present study was designed to investigate whether a combination of αTS and MSA would produce an additive or a greater than additive effect in suppressing AR level, AR transactivation, and prostate‐specific antigen (PSA).METHODS.LNCaP cells were treated with αTS alone for 31 hours, MSA alone for 3 hours, or αTS first for 28 hours and αTS/MSA together for the last 3 hours. AR and PSA mRNA levels were quantitated by quantitative reverse‐transcriptase polymerase chain reaction (qRT‐PCR). AR transactivation was determined by the ARE‐luciferase reporter assay. Both cellular and secretory PSA was also measured by the enzyme‐linked immunosorbent assay (ELISA) method.RESULTS.Different doses of αTS were evaluated in combination with MSA. Some striking results are highlighted below for αTS alone, MSA alone, or αTS/MSA (presented in that order). AR mRNA level was depressed by 0%, 20%, or 60%, respectively; AR transactivation was inhibited by 35%, 10%, or 60%, respectively; whereas the PSA mRNA level was decreased by 40%, 60%, or 90%, respectively. Interestingly, secretory PSA was consistently reduced to a greater extent than cellular PSA.CONCLUSIONS.A combination of αTS/MSA produced a greater than additive effect in suppressing AR signaling compared with the single agent. Decreased AR abundance is a major factor, but not necessarily the sole factor, in diminishing the transcriptional activity of AR by αTS or MSA. Cancer 2006. © 2006 American Cancer Society.
Critical evaluation of frozen section margins in head and neck cancer resections
Authors: Black Candice , Marotti Jonathan , Zarovnaya Elena , Paydarfar Joseph 
Published: November 2006

AbstractBACKGROUND.Negative resection margins are likely the most important prognostic factor for a patient with a head and neck squamous cell carcinoma. Frozen‐section evaluation allows a positive margin to be corrected before surgical closure and reconstruction. A final pathology report is later issued after examination of all resected tissues. The accuracy of the final pathology report relies on accuracy in the preceding steps. The current process of margin reporting in head and neck cancer resections was studied to reveal possible waste and error in the system.METHODS.Two hundred pathologists were surveyed about their center's current process of frozen‐section margin evaluation. The authors of the current study used the membership log of the North American Society of Head and Neck Pathology and the list of the top 50 US cancer centers according to US News and World Report. The authors analyzed the process of frozen‐section procedure using Toyota industry principles of quality improvement.RESULTS.The majority of surgeons send small fragments of tissue from the surgical defect cavity. Many pathologists receive small unoriented tissue fragments. Many resample all or most of the margins for the final pathology report without anatomic orientation from the surgeon. Other pathologists do not sample any margins.CONCLUSIONS.Final margin reporting redundancy and waste is due mainly to lack of anatomic correlation at interdisciplinary hand‐offs. Oversampling and undersampling of margins may be occurring, and the accuracy of the final pathology report may be compromised. There is currently no consensus on how to best submit tissue for frozen‐section evaluation of head and neck resection margins. Cancer 2006. © 2006 American Cancer Society.
Prox1 expression patterns in the developing and adult murine brain
Authors: Lavado Alfonso , Oliver Guillermo 
Published: November 2006

AbstractProx1, a homeobox gene related to the Drosophila gene prospero, is necessary for retina, lens, liver, pancreas, and lymphatics development. However, not much is yet known about Prox1 expression during central nervous system development. Here we provide a detailed analysis of Prox1 mRNA and protein expression during prenatal and postnatal murine brain development. Prenatally, Prox1 is expressed in the subventricular zone or in early differentiating regions of the brain. At these stages, Prox1 mRNA, but not Prox1 protein, was also detected in several regions of the prethalamus and hypothalamus. At an early postnatal stage, Prox1 expression is mainly detected in several nuclei of the thalamus, the cerebellum, and the hippocampus. In adulthood, Prox1 expression remains only in the hippocampus and cerebellum. These complex patterns of expression suggest that Prox1 activity is differentially required during brain development and adulthood. Developmental Dynamics 236:518–524, 2007. © 2006 Wiley‐Liss, Inc.
New Multidimensional Coordination Polymers with μ2‐ and μ3‐dcno Cyano Carbanion Ligand {dcno– = [(NC)2CC(O)O(CH2)2OH]–}
Authors: Benmansour Samia , Setifi Fatima , Triki Smail , Salaün Jean‐Yves , Vandevelde Fanny , Sala‐Pala Jean , Gómez‐García Carlos J. , Roisnel Thierry 
Published: November 2006

AbstractNew polymeric materials [M(dcno)2(H2O)2] [M = FeII (1), CoII (2)] and [M(dcno)2] [M = CuII (3), MnII (4)] with dcno– =[(NC)2CC(O)O(CH2)2OH]– = 2,2‐dicyano‐1‐(2‐hydroxyethoxy)ethenolate anion have been synthesised and characterised by IR spectroscopy, X‐ray crystallography and magnetic measurements. In compounds 1 and 2, each organic ligand acts in a bridging mode with its two nitrogen atoms bound to two different metal ions, while in compounds 3 and 4, each organic anion acts as a μ3‐bridging ligand through its two nitrogen atoms and the oxygen atom of the OH group. Each metal ion has a pseudo‐octahedral trans‐MN4O2 environment with four nitrogen atoms from four different organic ligands and two oxygen atoms from two water molecules in compounds 1 and 2 and from the OH group of the cyanocarbanion ligand in compounds 3 and 4. These coordination modes give rise to 1D, 2D and 3D arrangements for compounds 1, 2 and 3–4, respectively. Magnetic measurements show weak antiferromagnetic coupling between metal centres in the four compounds.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
The Complexes [OsCl2(azole)2(dmso)2] and [OsCl2(azole)(dmso)3]: Synthesis, Structure, Spectroscopic Properties and Catalytic Hydration of Chloronitriles
Authors: Stepanenko Iryna N. , Cebrián‐Losantos Berta , Arion Vladimir B. , Krokhin Artem A. , Nazarov Alexey A. , Keppler Bernhard K. 
Published: November 2006

AbstractTwo families of mixed‐ligand osmium(II) complexes, namely trans,cis,cis‐[OsIICl2(azole)2(dmso)2] [azole = indazole (1), pyrazole (2), benzimidazole (3) and imidazole (4)] and cis,fac‐[OsIICl2(azole)(dmso)3] [azole = indazole (5), pyrazole (6), benzimidazole (7) and imidazole (8)] have been prepared by taking advantage of the destabilising trans effect of the S‐bonded dmso ligands. These complexes have been characterised by microanalysis, IR, UV/Vis, 1H and 13C NMR spectroscopy, electrospray mass spectrometry, cyclic voltammetry and X‐ray crystallography. They have been found to catalyse the hydration of trichloroacetonitrile to trichloroacetamide and dichloroacetonitrile to dichloroacetamide with high selectivity. The catalyst efficiency depends strongly on the nature of the complex and the azole ligand present. The highest turnover (TON of 412 for trichloroacetamide and 578 for dichloroacetamide) and product yield (82.7 % for trichloroacetamide and 75.3 % for dichloroacetamide) have been achieved with complex 7. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
Enantioselective Synthesis of 3‐Methylisochromans and Determination of Their Absolute Configurations by Circular Dichroism
Authors: Kerti Gábor , Kurtán Tibor , Illyés Tünde‐Zita , Kövér Katalin E. , Sólyom Sándor , Pescitelli Gennaro , Fujioka Naoko , Berova Nina , Antus Sándor 
Published: November 2006

AbstractSeven (S)‐3‐methylisochromans with different substitution patterns on their aromatic rings, and hence with different directions of their sum electric transition moments, were synthesized by ring‐closure of optically active (S)‐1‐arylpropan‐2‐ol derivatives. The (S)‐1‐arylpropan‐2‐ols were obtained by kinetic resolution and their absolute configurations were determined with the aid of a zinc porphyrin tweezer and by Mosher’s method. A systematic CD study of substituted isochroman derivatives revealed that, unlike in the cases of chiral tetralin and 2,3‐dihydrobenzo[b]furan chromophores, the presence of achiral substituents of large spectroscopic moment (e.g., OMe) on the aromatic ring does not change the helicity rule of the “unsubstituted” isochroman chromophore: (P)/(M) helicity of the isochroman heteroring resulted in positive/negative 1Lb band Cotton effects (CE) regardless of the nature(s) and position(s) of the substituent(s). (S)‐3‐Methylisochromans were oxidized at C‐1, allowing access to the corresponding dihydroisocoumarins, in which positive CE of the n→π* transitions were correlated with (P) helicity and (S) absolute configuration. On DDQ‐assisted oxidation, two trans‐1‐methoxy‐3‐methylisochroman derivatives were prepared and used to study the effect of the axial benzylic C‐1 methoxy group on the conformation of the heteroring and the 1Lb band CE. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
Synthesis of [11C]/[13C]Acrylamides by Palladium‐Mediated Carbonylation
Authors: Eriksson Jonas , Åberg Ola , Långström Bengt 
Published: November 2006

AbstractTwo methods are presented for the synthesis of acrylamides labelled with 11C (β+, t1/2 = 20.4 min) and 13C in the carbonyl position. In the first method, [1‐11C]acrylic acid is synthesised from [11C]carbon monoxide by palladium‐mediated hydroxycarbonylation of acetylene. The labelled carboxylic acid is converted into the acyl chloride and subsequently treated with amine to yield N‐benzyl[carbonyl‐11C]acrylamide. The second method utilizes [11C]carbon monoxide in a palladium‐mediated carbonylative cross‐coupling of vinyl halides and amines. A higher radiochemical yield is achieved with the latter method and the amount of amine needed is decreased to 1/20. The 11C‐labelled acrylamides were isolated in up to 81 % decay‐corrected radiochemical yield. Starting from 10 ± 0.5 GBq of [11C]carbon monoxide, N‐benzyl[carbonyl‐11C]acrylamide was obtained in 4 min with a specific radioactivity of 330 ± 4 GBq μmol–1. Co‐labelling with 11C and 13C enabled confirmation of the labelled position by 13C NMR spectroscopy. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
Chiral Piperazines as Efficient Catalysts for the Asymmetric Michael Addition of Aldehydes to Nitroalkenes
Authors: Barros Maria Teresa , Faísca Phillips Ana Maria 
Published: November 2006

AbstractChiral piperazines were used as efficient catalysts in the addition of unmodified aldehydes to nitroalkenes. The nature of the solvent, temperature, and catalyst load were found to influence the outcome of the reaction. The products were obtained in good yields up to 88 %, high diastereoselectivities up to 97:3, and high enantiomeric excesses up to 85 %. Plain piperazine and its monohydrochloride were used efficiently as organocatalysts in the synthesis of racemic γ‐formylnitroalkanes. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
Asymmetric Synthesis of 1‐Substituted Tetrahydro‐3‐benzazepines as NMDA Receptor Antagonists
Authors: Wirt Ursula , Schepmann Dirk , Wünsch Bernhard 
Published: November 2006

AbstractA novel asymmetric synthesis of 1‐substituted tetrahydro‐3‐benzazepines (R)‐15 and (S)‐15 has been performed. Starting with o‐phenylenediacetic acid (1) and (R)‐phenylglycinol as chiral auxiliary the tricyclic oxazololactam (3R)‐10 was synthesized as key intermediate. Deprotonation of (3R)‐10 with LDA led to an enolate, which was trapped with different arylalkyl and alkyl halides to yield 6‐substituted oxazololactams (6R)‐12 with high diastereoselectivity. The best diastereomeric ratio (about 95:5) was achieved with benzyl bromide and 2‐methylbenzyl bromide. The diastereomers were separated using preparative HPLC to obtain diastereomerically pure (6R)‐12. Two successive reduction procedures (LiAlH4/AlCl3, then NH4HCO2, Pd/C) led to enantiomerically pure 1‐substituted tetrahydro‐3‐benzazepines (R)‐15. Starting the synthesis with (R)‐ and (S)‐phenylglycinol provided both enantiomers (R)‐15 and (S)‐15, which were investigated for their affinity to the PCP binding site of the NMDA receptor. The NMDA receptor affinities of the enantiomeric pairs are very similar. With a Ki value of 1.66 μM the 2‐methylbenzyl‐substituted derivative (R)‐15c displays the highest NMDA receptor affinity in this series. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
On the Phenyliodine(III)‐Bis(trifluoroacetate)‐Mediated Olefin Amidohydroxylation Reaction
Authors: Tellitu Imanol , Urrejola Andrea , Serna Sonia , Moreno Isabel , Herrero M. Teresa , Domínguez Esther , SanMartin Raul , Correa Arkaitz 
Published: November 2006

AbstractWhen appropriately substituted amides are treated with PIFA in a non‐nucleophilic solvent like trifluoroethanol, a stable N‐acylnitrenium ion is generated. If under such conditions a C=C double bond is present in the molecule, an intramolecular cyclization process takes place in an exo mode with additional generation of a hydroxy group at the terminal position of the original olefin moiety to render a series of pyrrolidine and piperidine derivatives. In this paper, proofs are offered to conclude that, according to our assumption, an ionic mechanism rather than a radical one must be considered. Additionally, a study of the scope of this cyclization protocol is conducted using substrates with different substituents either on the amidic nitrogen or all along the carbon chain.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)