bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigation of the Role of Zirconia and Zirconia-containing Systems as Catalysts in
Organic Transformations
Authors: Nikoofar Kobra , Shaddel Negin , Jozi Fatemehsadat 
Published: March 2024

Abstract:
This review article discusses the applications of zirconia as a catalyst to promote
various organic reactions and transformations. The article is subdivided into four main
parts: 1) introduction, which consists of the history and introduction of zirconia, elaboration
of its synthetic procedures, its application in various fields of science and technology with
specified examples, and previously published review articles on ZrO2; 2) applications of
sole zirconia and zirconia-based catalytic systems to promote various organic transformations,
subdivided into oxidation reactions, hydrolysis and methanation reactions, reduction
and hydrogenation reactions, furfural and synthesis of its derivatives, and miscellaneous
reactions; 3) applications of sole zirconia and nano-sized ZrO2 to catalyze organic reactions
and MCRs, classified as two-component reactions, three-component reactions (by a
glance at pseudo 3-CRs), and four-component reactions (by a glance at pseudo 4-CRs); and 4) applications of
zirconia-containing catalytic systems to catalyze organic transformations and MCRs classified as twocomponent
reactions, three-component reactions, and four-component and higher-component reactions. According
to investigations, some of the zirconia-based catalysts exist in nano-sized systems. Moreover, the literature
survey contains publications up to the end of July 2023.
Design, Synthesis, and Antimicrobial Evaluation of Novel Sulfonamide Modified with
Azoles
Authors: Periwal Pratibha , Kumar Ashwani , Verma Vikas , Kumar Devinder , Parshad Mahavir , Bhatia Meenakshi , Thakur Sourbh 
Published: March 2024

Abstract:
Sulfonamide, imidazole, and triazole chemical nuclei possess good antimicrobial
potential. This study aimed to amalgamate sulfonamide, imidazole, and triazole moieties in a
single molecular framework with the intent of improving their antimicrobial activities. The
objective of this study was the synthesis of conjugates containing sulfonamide and azole
moieties along with in vitro and in silico evaluation as antimicrobial candidates. A series of
sulfonamide-modified azoles (7a-r) was synthesized by multicomponent condensation of
1,2-dicarbonyl compounds, ammonium acetate and aryl-substituted aldehydes in glacial
acetic acid. The structure of synthesized molecules was elucidated with the help of various
spectroscopic techniques, such as FTIR, NMR, and HRMS. The target molecules were tested
for in vitro antimicrobial potency against four bacterial strains and two fungal strains. Molecules 7c (MIC
0.0188 μmol/mL), 7f (MIC 0.0170 μmol/mL) and 7i (MIC 0.0181 μmol/mL) were most active against S. aureus
and C. albicans. Against E. coli, molecules 7d (MIC 0.0179 μmol/mL), 7f (MIC 0.0170 μmol/mL) and 7i (MIC
0.0181 μmol/mL) were found to be highly active. Moreover, the binding conformations were investigated by insilico
molecular docking, and QTAIM (Quantitative theory of atoms in the molecule) analysis was also performed.
Molecular properties, such as the heat of formation, HOMO energy, LUMO energy and COSMO volume,
were found to be in direct correlation with the antimicrobial potency of molecules 7c, 7f and 7i against S.
aureus and C. albicans. All the synthesized molecules were more potent than clinically approved sulfonamides,
namely sulfadiazine and sulfabenzamide.
Importance and Green Synthesis of Amines: A Review
Authors: Patel Ashok Raj , Patel Ishwar , Banerjee Subhash 
Published: March 2024

Abstract:
Amines are “derivatives of ammonia” and important key intermediates for applications
in the industrial, pharmaceutical, electronics, etc. They have been used to synthesize
industrially important azo dyes, which are used to color various materials. Moreover, amine
functionality is present in several important biological molecules. Biogenic amines are
found in living organisms and play essential physiological functions in the body. They are
prepared from the amination and transamination reaction of carbonyl compounds such as
aldehydes and ketones and the decarboxylation reaction of amino acids. Thus, the various
applications and requirements of essential amine scaffolds paid attention to researchers to
develop novel synthetic protocols to synthesize these compounds. In organic chemistry,
various methods synthesize amines; however, green synthetic methods have recently become
a trend. By writing this review, our main focus was to provide a brief on the importance of some biogenic
amines and the synthesis of both amines via green synthetic methods.
Unlocking the Potential of RNA Nanoparticles: A Breakthrough Approach
to Overcoming Challenges in Colon Cancer Treatment
Authors: Karati Dipanjan , Mukherjee Swarupananda , Basu Biswajit , Garala KevinKumar , Dutta Ayon , G. Prajapati Bhupendra , Bhattacharya Sankha 
Published: March 2024

Abstract:
Globally, one of the leading causes of cancer-related deaths is colon cancer. As this
form of cancer has a tremendous potential to metastasize, effective treatment is complicated
and sometimes impossible. Despite the improvement of conventional chemotherapy and the
advent of targeted therapies, overcoming multi-drug resistance (MDR) and side effects remain
significant challenges. As a therapeutic intervention for targeted gene silencing in cancer,
RNA technology shows promise and certain RNA-based formulations are currently undergoing
clinical studies. Various studies have reported that RNA-based nanoparticles have demonstrated
substantial promise for targeted medication delivery, gene therapy, and other biomedical
applications. However, using RNA as a therapeutic tool presents severe limitations, mainly
related to its low stability and poor cellular uptake. Nanotechnology offers a flexible and tailored
alternative due to the difficulties in delivering naked RNA molecules safely in vivo, such
as their short half-lives, low chemical stability, and susceptibility to nuclease degradation. In
addition to shielding RNA molecules from immune system attacks and enzymatic breakdown,
the nanoparticle-based delivery systems allow RNA accumulation at the tumor site. The potential
of RNA and RNA-associated nanomedicines for the treatment of colon cancer, as well
as the prospects for overcoming any difficulties related to mRNA, are reviewed in this study,
along with the current progress of mRNA therapeutics and advancements in designing nanomaterials
and delivery strategies.
Whole Transcriptome Sequencing of Peripheral Blood Identifies the
Alzheimer's Disease-Related circRNA-miRNA-lncRNA Pathway
Authors: Gu Yucheng , Chen Nihong , Zhu Lin , Chen Xiangliang , Jiang Teng , Zhang Yingdong 
Published: March 2024

Background::
Previous studies on transcriptional profiles suggested dysregulation of
multiple RNA species in Alzheimer’s disease. However, despite recent investigations revealing
various aspects of circular RNA (circRNA)-associated competing endogenous RNA (ceRNA)
networks in Alzheimer's Disease (AD) pathogenesis, few genome-wide studies have explored
circRNA-associated profiles in AD patients exhibiting varying degrees of cognitive loss.

Objective::
To investigate the potential pathogenesis-related molecular biological changes in the
various stages of AD progression.

Methods::
Whole transcriptome sequencing was performed on the peripheral blood of 7 normal
cognition (NC) subjects, 8 patients with mild cognitive impairment, 8 AD patients with mild
dementia (miD), and 7 AD patients with moderate dementia (moD). Gene Ontology (GO) analysis
and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were conducted
to predict the potential functions of the maternal genes of microRNAs (miRNAs), circRNAs and
long non-coding RNAs (lncRNAs). The construction of ceRNA network was performed between
the NC group and each diseased group based on the differently expressed RNAs.

Results::
In total, 3568 messenger RNAs (mRNAs), 142 miRNAs, 990 lncRNAs, and 183
circRNAs were identified as significantly differentially expressed across the four groups. GO
and KEGG enrichment analysis revealed the significant roles of GTPase activity and the MAPK
signaling pathway in AD pathogenesis. A circRNA-miRNA-lncRNA ceRNA pathway, characterized
by the downregulated hsa-miR-7-5p and upregulated hsa_circ_0001170, was identified
based on the differentially expressed RNAs between the NC group and the moD group.

Conclusion::
The study suggests that circRNAs may be independent of mRNAs in AD pathogenesis
and holds promise as potential biomarkers for AD clinical manifestations and pathological
changes.
Optimization of Malabar Nut (Justicia adhatoda L.) Leaves’ Phenolic Compounds by Alginate Emulsion-gelation Approach using Response Surface Methodology
Authors: Chebout Afaf , Ydjedd Siham , Chaalal Makhlouf , Himed Louiza 
Published: March 2024

Background:
The encapsulation technique is an effective method for coating bioactive
molecules and protecting them against various technological treatment conditions during production processing.

Objective:
The aim of this study was to optimize the encapsulation conditions of phenolic compounds extracted from Malabar nut (Justicia adhatoda L.) leaves by alginate emulsion-gelation
approach using response surface methodology

Methods:
The ionotropic gelation method was used to encapsulate the phenolic compounds of
Malabar nut (Justicia adhatoda L.) leaves. The optimization of this phenolic compounds encapsulation was carried out using response surface methodology through Box˗Behnken design. Four
parameters with three levels (-1, 0, +1) were chosen including sodium alginate concentration
(2 – 3 - 4%), calcium chloride concentration (4 - 6 - 8%), plant extract-alginate solution ratio
(0.02 – 0.11 - 0.2 mg/ml), and gelation time (5 – 12.5 - 20 min). of the total phenolic and flavonoid contents encapsulation efficiency was assessed. Likewise, the antioxidant activity was evaluated using ferric-reducing power (FRP) and free radical scavenging activity (DPPH).

Results:
The results of response surface methodology analysis using Box˗Behnken design
showed that the optimal encapsulation conditions were 3.11% for alginate concentration, 5.74%
for calcium chloride concentration, 0.1 mg/ml for the plant extract-alginate solution ratio, and
10.80 min for gelation time. Under these conditions, the optimum values of total phenolic and
flavonoid encapsulation efficiency were 86.17% and 75.69%, respectively, 126.75 mg AAE/100
g for ferric reducing power and 97.29% for DPPH. The experimental and prediction results have
expressed a high significant level for all responses.

Conclusion:
The method revealed the validity of elaborated models through response surface
methodology optimization processes for phenolic antioxidants encapsulation of Malabar nut
(Justicia adhatoda L.) leaves extract.
Characteristics of Users of a Digital Hypnotherapy Intervention for Hot Flashes: Retrospective Study
Authors: Snyder Morgan , Elkins Gary R 
Published: March 2024

Background
Hot flashes are associated with a lower quality of life and sleep disturbances. Given the many consequences of hot flashes, it is important to find treatments to reduce them. Hypnotherapy, the use of hypnosis for a medical disorder or concern, has been shown in clinical trials to be effective in reducing hot flashes, but it is not routinely used in clinical practice. One solution to close this implementation gap is to administer hypnotherapy for hot flashes via a smartphone app. Evia is a smartphone app that delivers hypnotherapy for hot flashes. Evia has made hypnotherapy more widely accessible for women who are experiencing hot flashes; however, the app has yet to undergo empirical testing. Additionally, research on user characteristics is lacking.

Objective
This study aims to (1) determine the average age, stage of menopause, and length of menopause symptoms for users of the Evia app; (2) determine the characteristics of hot flashes and night sweats for users of the Evia app; (3) determine the self-reported sleep quality of users of the Evia app; (4) determine the self-reported mental health of users of the Evia app; and (5) determine the relationship between hot flash frequency and anxiety and depression for users of the Evia app.

Methods
This study analyzed data collected from participants who have downloaded the Evia app. Data were collected at 1 time point from a self-report questionnaire that assessed the demographic and clinical characteristics of users. The questionnaire was given to users when they downloaded the Evia app. Users of the Evia app fill out a questionnaire upon enrolling in the program and prior to beginning the intervention. This included 9764 users.

Results
Results showed that the mean age of users was 49.31 years. A total of 41.6% (1942/4665) of users reported experiencing 5 or more hot flashes per day, while 51.2% (1473/2877) of users reported having difficulty falling asleep each night and 47.7% (1253/2626) of users reported their sleep quality to be terrible. In addition, 38.4% (1104/2877) of users reported that they often feel anxious or depressed. There was a small, significant, and negative correlation between hot flash frequency and self-report frequency of anxiety and depression (r=–0.09).

Conclusions
This study showed that the average age of app users is in line with the median age of natural menopause. A large percentage of users reported experiencing 5 or more hot flashes per day, reported difficulties with sleep, and reported experiencing depression and anxiety. These findings are in line with previous studies that assessed hot flash frequency and the consequences of hot flashes. This was the first study to report on the characteristics of users of the Evia app. Results will be used to optimize the hypnotherapy program delivered via the Evia app.
A Personalized and Interactive Web-Based Advance Care Planning Intervention for Older Adults (Koda Health): Pilot Feasibility Study
Authors: Roberts R Lynae , Cherry Katelin D , Mohan Desh P , Statler Tiffany , Kirkendall Eric , Moses Adam , McCraw Jennifer , Brown III Andrew E , Fofanova Tatiana Y , Gabbard Jennifer 
Published: March 2024

Abstract

Background
Advance care planning (ACP) is a process that involves patients expressing their personal goals, values, and future medical care preferences. Digital applications may help facilitate this process, though their use in older adults has not been adequately studied.

Objective
This pilot study aimed to evaluate the reach, adoption, and usability of Koda Health, a web-based patient-facing ACP platform, among older adults.

Methods
Older adults (aged 50 years and older) who had an active Epic MyChart account at an academic health care system in North Carolina were recruited to participate. A total of 2850 electronic invitations were sent through MyChart accounts with an embedded hyperlink to the Koda platform. Participants who agreed to participate were asked to complete pre- and posttest surveys before and after navigating through the Koda Health platform. Primary outcomes were reach, adoption, and System Usability Scale (SUS) scores. Exploratory outcomes included ACP knowledge and readiness.

Results
A total of 161 participants enrolled in the study and created an account on the platform (age: mean 63, SD 9.3 years), with 80% (129/161) of these participants going on to complete all steps of the intervention, thereby generating an advance directive. Participants reported minimal difficulty in using the Koda platform, with an overall SUS score of 76.2. Additionally, knowledge of ACP (eg, mean increase from 3.2 to 4.2 on 5-point scale; P<.001) and readiness (eg, mean increase from 2.6 to 3.2 on readiness to discuss ACP with health care provider; P<.001) significantly increased from before to after the intervention.

Conclusions
This study demonstrated that the Koda Health platform is feasible, had above-average usability, and improved ACP documentation of preferences in older adults. Our findings indicate that web-based health tools like Koda may help older individuals learn about and feel more comfortable with ACP while potentially facilitating greater engagement in care planning.
Bibliometric Analysis of the Research Landscape in Human-Computer Interaction in Ibero-America
Authors: Solis Pino Andrés Felipe , Ruiz Pablo H. , Agredo-Delgado Vanessa , Mon Alicia , Collazos Cesar Alberto 
Published: March 2024

Human-Computer Interaction (HCI) is a research discipline that optimizes human-machine interfaces. Ibero-America has become a leading region in HCI advances adapted to its unique socioeconomic environment. However, a global characterization of the research landscape for this discipline in the region still needs to be improved. Therefore, this study aimed to analyze the scientific literature on HCI in Ibero-America using bibliometric techniques, identifying key authors, institutions, conceptual structure, and research trends. The methodology employed consisted of a bibliometric analysis of 9812 documents from 1990-2023 from Scopus and Web of Science. The data were analyzed using Bibliometrix and VOSviewer for statistical and network analysis. The results revealed that Spain, Brazil, Portugal, Mexico, and Colombia are at the forefront of HCI research in the region, with more than 90 % of total publications experiencing an annual growth rate of approximately 14.6 %, driven by strong international collaborations. Key topics are human-computer interaction, virtual reality, augmented reality, and video games, while education is one of the main application areas. The main conclusion is that the HCI research landscape in Ibero-America is characterized by rapid evolution, international integration, and conceptual diversity, indicative of a mature and interdisciplinary field that responds to regional demands. The advancement of the field could be driven by increased private-sector funding. Future system designs in the region should prioritize cultural sensitivity and inclusion.
The Effect of Mandatory CSR Disclosures on Corporate Tax Avoidance: Evidence from a Quasi-Natural Experiment
Authors: Cao June , Haji Abdifatah Ahmed , Hu Jinshuai 
Published: March 2024

ABSTRACT
We examine whether and how mandatory corporate social responsibility (CSR) disclosures affect corporate tax avoidance. Using a CSR disclosure mandate in China that requires a subset of firms to disclose their CSR activities as an exogenous shock to CSR disclosures, our difference-in-differences analyses show that firms affected by the disclosure mandate engage in less tax avoidance relative to control firms. Additional analyses indicate that increased public scrutiny following the disclosure mandate is the likely channel through which mandatory CSR disclosures constrain tax avoidance. Cross-sectional analyses suggest that the effect of the disclosure mandate varies with institutional environments. Overall, our results indicate that the CSR disclosure mandate constrains corporate tax avoidance, which is consistent with mandatory CSR disclosures nudging firms toward more socially desirable behavior.
Diversity in Clinical Trials: A Complicated Issue, Not a Simple Solution
Authors: Brown-Friday Janet 
Published: March 2024

Editor’s note
This article is adapted from a speech Ms. Brown-Friday delivered in June 2023 as President, Health Care & Education, of the American Diabetes Association. She delivered her address at the Association’s 83rd Scientific Sessions in San Diego, CA. A webcast of this speech is available for viewing on the DiabetesPro website (https://events.diabetes.org/live/25/page/186).
Pemetaan Partisipatif Batas Korong Nagari dengan Memanfaatkan Teknologi Unmanned Aerial Vehicle (UAV)
Authors: Prihantarto Wikan Jaya , Ismail Muhammad , Susetyo Bigharta Bekti 
Published: March 2024

Pembangunan wilayah membutuhkan data spasial batas wilayah yang baik dan terperinci, bahkan hingga unit administrasi terkecil seperti dusun jika memungkinkan. Meskipun demikian, pemetaan batas memiliki tantangan teknologi, pengetahuan dan perbedaan perspektif dalam masyarakat. Pendekatan partisipatif diperlukan untuk menyelesaikan permasalahan batas administrasi dengan pelibatan elemen masyarakat yang berkepentingan. Selain itu diperlukan suatu alih pengetahuan untuk memberikan pemahaman mengenai kaidah ilmiah dalam penegasan batas wilayah. Kegiatan pengabdian ini ditujukan untuk memetakan batas antar korong di Nagari Anduriang, Kecamatan 2 x 11 Kayu Tanam, Kabupaten Padang Pariaman secara partisipatif. Kegiatan dilakukan dengan memanfaatkan Peta Rupa Bumi Indonesia sebagai dasar dalam pemetaan batas tentatif. Selanjutnya, dilaksanakan Focus Group Discussion (FGD) antar perwakilan korong untuk menyepakati batas antar wilayah. Titik-titik penting sepanjang batas selanjutnya diinspeksi dan didokumentasikan menggunakan Unmanned Aerial Vehicle (UAV) dengan pendampingan oleh tenaga ahli. Hasil dari kegiatan ini adalah peta batas korong nagari. Peta batas tersebut dapat dimanfaatkan sebagai dasar dalam pembangunan di setiap korong nagari. Selain itu, pelibatan masyarakat diharapkan dapat memberikan sumbangsih pengetahuan terhadap teknologi dan metode penegasan batas sesuai dengan kaidah ilmiah.
HOSPITAL FOOD SERVICE ASSESSMENT IMPROVING NUTRITIONAL INTAKE INPATIENTS: A LITERATURE REVIEW
Authors: Arief Ria Qadariah , Widayanti Linda Prasetyaning , Hidayanti Sri , Oktorina Sarita , Arief Maryam Jamila , Alam Syamsul 
Published: March 2024

Background: Malnutrition in hospitals is a commonly occurring and often overlooked issue that impacts not only the clinical outcomes of patients, such as their length of stay, morbidity, mortality, and quality of life, but also the overall sustainability of the healthcare system. column format. Aims: The purpose of writing this systematic literature review is to collect scientific evidence regarding food service satisfaction assessment techniques for inpatients in hospitals. Method: This research conducting a literature review using PRISMA guidelines, using data based on Google Scholar and Scopus which examined the level of patient satisfaction with food services in hospitals.
Result: From the six papers that we analyzed, we obtained an assessment process for the level of patient satisfaction using caloric intake calculations, and some used validated questionnaires, and obtained several appropriate strategies to increase the nutritional intake of inpatients. Conclusions: Assessing the patient's nutritional and nutritional intake is very important in determining the patient's health and recovery.
Growing the Next Generation of Horticulture Customers and Stakeholders through Industry and Extension Outreach Collaborations
Authors: Bumgarner N. , Rihn A. , Campbell J. , Dorn S. , Kirk-Ballard H. 
Published: March 2024

Abstract
As the horticulture consumer base transitions to younger generations, educational outreach collaborations between Extension and industry could be a mutually beneficial way to serve an increasingly diverse customer audience. A recent study investigated drivers of, and opportunities for, increased participation in plant-related activities using an online survey of 2,134 respondents. Both participants and non-participants in plant-related activities were surveyed. Some of the commonly cited reasons for non-participation were a lack of knowledge and overall success, illustrating an opportunity for education to be beneficial. While many plant retailers may not have the personnel or resources to engage widely in education, collaborations with Extension could be a viable path to address knowledge limitations of their customers and increase engagement in horticulture.