bluuebunny/crossref_metadata_2025_split huggingface dataset:
Percutaneous nephrolithotomy in case of crossed fused renal ectopia: a case report
Authors: Anand Ankit , Gupta Prakriti , Gupta Sumit , Tripathi Arpit , Mishra Shailja 
Published: February 2024

Crossed renal ectopia is a rare congenital anomaly that is frequently associated with gastrointestinal, cardiovascular, genital, and bone malformations. To best of our knowledge, there aren't many cases of inferior crossed fused renal ectopia of the right kidney documented in the literature at this time. A case of crossed-fused renal ectopia is presented here. A 32-year-old man arrived at our hospital complaining of pain in the right flank. Diagnosis: We suspected a single right kidney based on abdominal ultrasonography. An inferior left to right crossed-fused ectopic kidney with calculus in the right (normal) renal pelvis was the patient's diagnosis when combined with 3D computed tomography. Interventions: percutaneous nephrolithotomy with DJ stenting. Because the management of renal stone in this uncommon malformation is complicated, a preoperative assessment with contrast computed tomography is required before moving forward with surgery in order to explore a single kidney with calculi and avoid missing the diagnosis of crossed fused renal ectopia.
Awareness of parents of preschool children about selected heavy metals in food
Authors: Dolibóg Magdalena , Osmala-Kurpiewska Weronika 
Published: February 2024

WstępDziałalność człowieka przyczyniła się do szerokiego rozpowszechnienia metali ciężkich w środowisku naturalnym. Skutki narażenia na metale ciężkie mogą się ujawnić dopiero po upływie wielu lat. Narażenie dzieci na metale ciężkie drogą pokarmową może stanowić istotne ryzyko zdrowotne, dlatego wiedza oraz postawy zdrowotne rodziców i opiekunów prawnych mają niebagatelne znaczenie w zakresie minimalizacji ryzyka zdrowotnego dzieci. Celem pracy była ocena poziomu wiedzy rodziców na temat metali ciężkich, ich występowania w żywności oraz zagrożeń dla zdrowia dzieci, wynikających ze spożywania żywności zanieczyszczonej metalami ciężkimi.Materiał i metodyNarzędzie badawcze stanowił autorski kwestionariusz ankiety, składający się z części „metryczka” oraz pytań zamkniętych, głównie jednokrotnego wyboru. Grupę badaną stanowiło 100 rodziców z dwóch placówek przedszkolnych zlokalizowanych na terenie województwa śląskiego. Wyniki kwestionariusza ankiety zostały opracowane w programie Microsoft Office Excel 2019. Za pomocą programu Statistica 13 (StatSoft) wykonano analizę statystyczną (test chi-kwadrat), a istotność statystyczną przyjęto na poziomie α = 0,05.WynikiRodzice dzieci w wieku przedszkolnym nie są świadomi zagrożeń związanych z ekspozycją na metale ciężkie. Większość respondentów nie zapoznawała się z informacjami ogólnymi na temat obecności metali ciężkich w produktach spożywczych.WnioskiŚwiadomość rodziców dzieci w wieku przedszkolnym dotycząca wybranych metali ciężkich występujących w żywności jest niska. Wskazane jest wdrożenie działań edukacyjnych w celu zwiększenia poziomu wiedzy rodziców na temat możliwych następstw zdrowotnych i sposobów zmniejszania ryzyka zdrowotnego wynikającego z narażenia na metale ciężkie drogą pokarmową.
Economia Circular, Gestão da Cadeia de Suprimentos e Commodities: Agenda de Pesquisa no Contexto Sustentável
Authors: Johann Daiane , Santos Ruan Carlos dos , Tutida Alessandra Yula 
Published: February 2024

Objetivo: A pesquisa aborda a implementação da economia circular na cadeia de suprimentos sustentável, viabilizado por meio dos comodities no contexto sustentável. O artigo busca maiores níveis de sustentabilidade, atendendo a forte mobilização da sociedade por produtos com melhores desempenhos ambientais.
Método: Apesar de muitos estudos abordarem separadamente os conceitos, poucos estudos avançam na visão integrada de funcionamento da cadeia de suprimentos de produtos circulares. A revisão sistemática da literatura buscou relacionar a integração dos conceitos identificando aspectos chaves das partes interessadas, processos e ferramentas, que podem ser sincronizados para auxiliar as organizações na implantação do ambiente circular nas operações da cadeia de suprimentos e gerar ganhos de sustentabilidade.
Resultados: A evolução da cadeia de suprimentos como um resultado das necessidades de competição dos produtores, visando melhorias de mercado e redução de custos, a geração de valor ao longo da cadeia está muito focada na entrega de especificidade ao cliente. Por isso, a cadeia de suprimentos é sustentável, pois precisa obter um bom desempenho em medidas financeiras tradicionais, incluindo que se trata de sustentabilidade na cadeia de suprimentos para formar as três dimensões: social, ambiental e econômica.
Conclusão: O trabalho abre caminho para pesquisas futuras e aplicações práticas, considerando a necessidade de funcionamento sistêmico de tecnologias que promovam a atuação conjunta e ambiente de cooperação entre organizações, que favoreçam ganhos de sustentabilidade.
WITHDRAWN: Dark Current in Pinned Photodiode CMOS Image Sensors: A Pre-Fabrication Physics-based Model
Authors: Suharwerdi Mohsin , Qazi Gausia 
Published: February 2024

Abstract
The full text of this preprint has been withdrawn by the authors in order to comply with an institutional policy on preprints. Therefore, the authors do not wish this work to be cited as a reference.
A strategic optimizing carbon neutrality within profit and emission reduction efficiency: A Stackelberg game analysis under a cap-and-trade scheme
Authors: Hussain Jafar , Lee Chien-Chiang , Ren Jifan 
Published: February 2024

Abstract

Carbon emissions (CO2e) are a main problem, and many countries are committed to reducing CO2e to attain carbon neutrality. To narrow this gap, this research considers green technology implementation (GTI) and CO2e quota in dual green gaming. The objective is to explore the integration of GTI and CO2e quotas into optimal production and pricing decisions in emission-generating companies (EGCs). To achieve this, a two-party simulation Stackelberg game model involving the CO2e strategy of EGCs and governments is proposed. We formulate a mathematical model and experimental methods to optimize EGCs' decision-making using neutral indicators. EGCs optimize production quantity, achieving CO2e reduction through ERE maximization. EGCs exhibit a strong commitment to ERE enhancement practices, enhancing profit and carbon-neutral goals. Our findings demonstrate the effectiveness of CO2e quotas and GTI as carbon-neutral indicators in EGCs, contributing to global carbon emission reduction. Our research provides both literature and inspiration for global CO2e reduction efforts. Moreover, it aids governments in exploring optimal incentives and decisions for pricing and production. Last, this work enables EGCs to maximize profits and move toward a carbon-neutral environment.
Genomic heterogeneity of Multidrug Resistance E.coli recovered from diarrheagenic children under five years from Mukuru Informal Settlement, Nairobi, Kenya
Authors: Kiiru Susan , Kasiano Purity , Maina John , Mwaniki John Njeru , Songoro Edinah , Kariuki Samuel 
Published: February 2024

Abstract
Introduction High genomic plasticity within E. coli enables it to acquire and accumulate genetic material through horizontal gene transfer like mobile genetic elements. In this study, we sought to investigate the virulence genes, phylogroups, antibiotic resistance genes( ARGs), plasmid replicons, MLST, and cgMLST of multidrug-resistant E.coli recovered from diarrheagenic children under five years from Mukuru Informal Settlement, Nairobi Kenya.
Methods A total of 39 MDR strains had their DNA extracted, and Whole Genome Sequencing was done using the Illumina HiSeq 2500 platform. Twenty-six E.coliassemblies were analyzed using web-based bioinformatics tools available at the Centre for Genomic Epidemiology (TDU) and EnteroBase.
Results The isolates fell into 4 main phylogroups, where 10/26(38.5%) belonged to the B2 phylogroup, 4/26 ( 15.4%) belonged to D, 3/26( 11.5%) belonged to A, 1/26( 3.8%) belonged to B1, while 8/26 ( 30.8%) were not determined. FimH30 was predominantly found in the most frequent phylogroup B2 and Sequence Type(ST) 131. A total of 40 diverse virulence genes were detected among the isolates. 13 different STs were isolated from the E. coli genomes, which included ST 131, ST 3036, ST 38, ST 10, ST 12569, ST 15271, ST 2076, ST 311, ST 3572, ST 394, ST 453, ST 46 and ST 1722. Only two isolates ( 2/26, 7.7%) from the Municipal City Council ( MCC) clinic were genetically related. Additionally, the most abundant plasmid replicon identified belonged to the IncF family, IncFII(pRSB107) in particular, followed by the Col family. Of 26 isolates, 15 had at least one nonsynonymous mutation in the housekeeping genes gyrA (p.S83L), gyrA (p.D87N), parC (p.S80I), parC (p.E84V), parC(p.S57T), and parE(p.I529L),associated with resistance to fluoroquinolones.
Conclusion The study highlighted the first E.coli ST46 to harbor the NDM5 gene encoded in Col(BS512), IncFII(pRSB107), and IncFIB(AP001918) plasmid replicons in Kenya. We further demonstrated the diversity of MDR E. coli associated with diarrhea in an endemic setting in Kenya.
Loss of cholinergic input to the entorhinal cortex is an early indicator of cognitive impairment in natural aging of humans and mice
Authors: Ananth Mala R. , Gardus John D. , Huang Chuan , Palekar Nikhil , Slifstein Mark , Zaborszky Laszlo , Parsey Ramin V. , Talmage David A. , DeLorenzo Christine , Role Lorna W. 
Published: February 2024

Abstract

In a series of translational experiments using fully quantitative positron emission tomography (PET) imaging with a new tracer specific for the vesicular acetylcholine transporter ([18F]VAT) in vivo in humans, and genetically targeted cholinergic markers in mice, we evaluated whether changes to the cholinergic system were an early feature of age-related cognitive decline. We found that deficits in cholinergic innervation of the entorhinal cortex (EC) and decline in performance on behavioral tasks engaging the EC are, strikingly, early features of the aging process. In human studies, we recruited older adult volunteers that were physically healthy and without prior clinical diagnosis of cognitive impairment. Using [18F]VAT PET imaging, we demonstrate that there is measurable loss of cholinergic inputs to the EC that can serve as an early signature of decline in EC cognitive performance. These deficits are specific to the cholinergic circuit between the medial septum and vertical limb of the diagonal band (MS/vDB; CH1/2) to the EC. Using diffusion imaging, we further demonstrate impaired structural connectivity in the tracts between the MS/vDB and EC in older adults with mild cognitive impairment. Experiments in mouse, designed to parallel and extend upon the human studies, used high resolution imaging to evaluate cholinergic terminal density and immediate early gene (IEG) activity of EC neurons in healthy aging mice and in mice with genetic susceptibility to accelerated accumulation amyloid beta plaques and hyperphosphorylated mouse tau. Across species and aging conditions, we find that the integrity of cholinergic projections to the EC directly correlates with the extent of EC activation and with performance on EC-related object recognition memory tasks. Silencing EC-projecting cholinergic neurons in young, healthy mice during the object-location memory task impairs object recognition performance, mimicking aging. Taken together we identify a role for acetylcholine in normal EC function and establish loss of cholinergic input to the EC as an early, conserved feature of age-related cognitive decline in both humans and rodents.
Cortical markers of excitation/inhibition balance are associated with sensory responsivity from infancy in longitudinal cohorts enriched for autism and ADHD
Authors: Leno Virginia Carter , Begum-Ali Jannath , Goodwin Amy , Mason Luke , Pasco Greg , Narvekar Nisha , Pickles Andrew , Charman Tony , Johnson Mark , Jones Emily , Team The STAARS 
Published: February 2024

Abstract

Autism and ADHD are characterised by atypical sensory responsivity, and this may be driven by alterations in the balance of cortical excitation to inhibition (E/I). Studies in early development are required to establish the primary of effects. We utilised data from a prospective longitudinal cohort of infants with and without a family history (FH) of autism and/or ADHD (N=151; 55% male, 83% white). We extracted electroencephalography (EEG) metrics of E/I balance at 5, 10 and 14 months; the aperiodic exponent of the slope of the power spectrum (‘1/f’). Models estimated correlated latent growth curves of parent-reported hyper and hypo-responsivity between 10 – 36 months. Analyses tested associations between developmental trajectories of sensory responsivity and FH, parent-rated neurodevelopmental traits at 3 years and E/I balance. Results showed that FH-autism was associated with steeper increases in parent-reported hyper-responsivity between 10 to 36 months, whereas FH-ADHD was associated with steeper increases in hypo-responsivity. Higher hypo-responsivity at 10-month baseline was associated with both autistic and ADHD traits at 3 years. A steeper slope of hypo-responsivity predicted ADHD traits at 3 years. Neither the baseline or slope of hyper-responsivity was associated with FH-ADHD, or autistic or ADHD traits at 3 years. Males displayed higher baseline hypo-responsivity. Aperiodic exponent values at 5 and 10, but not 14 months, were associated with hyper-responsivity. Results suggest that hypo-responsivity in infancy may be an indicator of later autism and ADHD outcomes. Alterations in E/I balance may contribute to early differences in sensory responsivity and thus could represent a useful target for intervention development.
Subcellular functions of tau mediates repair response and synaptic homeostasis in injury
Authors: Grosshans David , Thomas Riya , Zhang Die , Cronkite Christopher , Thomas Rintu , Singh Sanjay , Bronk Lawrence , Morales Rodrigo , Duman Joseph 
Published: February 2024

Abstract
Injury responses in terminally differentiated cells such as neurons is tightly regulated by pathways aiding homeostatic maintenance. Cancer patients subjected to neuronal injury in brain radiation experience cognitive declines similar to those seen in primary neurodegenerative diseases. Numerous studies have investigated the effect of radiation in proliferating cells of the brain, yet the impact in differentiated, post-mitotic neurons, especially the structural and functional alterations remain largely elusive. We identified that microtubule-associated tau is a critical player in neuronal injury response via compartmentalized functions in both repair-centric and synaptic regulatory pathways. Ionizing radiation-induced injury acutely induces increase in phosphorylated tau in the nucleus and directly interacts with histone 2AX (H2AX), a DNA damage repair (DDR) marker. Loss of tau significantly reduced H2AX after irradiation, indicating that tau may play an important role in neuronal DDR response. We also observed that loss of tau increases eukaryotic elongation factor levels after irradiation, the latter being a positive regulator of protein translation. This cascades into a significant increase in synaptic proteins, resulting in disrupted homeostasis. Consequently, novel object recognition test showed decrease in learning and memory in tau-knockout mice after irradiation, and electroencephalographic activity showed increase in delta and theta band oscillations, often seen in dementia patients. Our findings demonstrate tau’s previously undefined, multifunctional role in acute responses to injury, ranging from DDR response in the nucleus to synaptic function within a neuron. Such knowledge is vital to develop therapeutic strategies targeting neuronal injury in cognitive decline for at risk and vulnerable populations.
Predictors of disability trajectories in individuals with spinal cord injury in mainland China
Authors: li lunlan , huang hui , feng linsheng , ding peipei , xia xiaoxiao , Dai Qing 
Published: February 2024

Abstract

Study Design: Observational cohort study.
Objectives: To identify classes of disability trajectories from spinal-cord injury to 6 months after discharge and to investigate whether psychosocial resources and disease factors can predict disability trajectory.
Setting: Spinal surgery in three Class III hospitals. Hospitals in China are divided into three classes (Class I, II and III). Class III hospitals are the highest-level hospitals in China.
Methods: All the participants were submitted to WHO Disability Assessment Schedule (WHO-DAS 2.0) at three times；and personal data anamnesis, hope, PTSD, social support
were recorded at first time. All the data collected by the master's students who participated in this study.
Results: Two disability trajectories were identified using the latent class growth model: the continuous high disability group (N=196, 93.3%) and the low starting point stabilization group (N=14, 6.7%). Participants with higher American Spinal Injury Association (ASIA) (β=1.26; 95% confidence interval [CI] 1.00-12.21) and more depression (β=0.249; 95% CI 1.05-1.56) in the stable condition after SCI surgery were more likely to be classified as having higher disability than those with a lower disability
trajectory. Occupation, annual family income, hope, social support, and Post-traumatic Stress Disorder (PTSD) cannot predict individuals belonging to trajectory classes.
Conclusion: These findings emphasize the importance of ASIA and depression in the early recovery stage after SCI and support the opinion that strengthening psychological nursing and rehabilitation management at an early stage after SCI will benefit individuals with a lower disability trajectory.
Trans-Ancestry Analysis of Psychosis Biotypes: Shared Polygenic Risk and Unique Genomic Associations
Authors: Gershon Elliot , Xia Cuihua , Alliey-Rodriguez Ney , Tamminga Carol , Keshavan Matcheri , Pearlson Godfrey , Keedy Sarah , Parker David , Lencer Rebekka , Hill Scot , Bishop Jeffrey , Gandal Michael , Wen Cindy , Dai Rujia , Chen Chao , Liu Chunyu 
Published: February 2024

Abstract

The Bipolar-Schizophrenia Network for Intermediate Phenotypes (B-SNIP) has categorized psychosis disorders (Schizophrenia, Schizoaffective Disorder and Bipolar Disorder) into three distinct Biotypes, based on neurobiological measurements in a multi-ancestry sample. Two recently developed post hoc ancestry adjustment methods of Polygenic Risk Scores (PRSs) generate Trans-Ancestry PRSs (TAPRSs), which allow for PRS analysis of multi-ancestry samples. Applied to schizophrenia PRS, we found the Khera TAPRS method to show superior portability and comparable prediction accuracy as compared with the Ge method. The three Biotypes of psychosis disorders had similar TAPRSs across ancestries. In genomic analysis of Biotypes, nine genes and isoforms showed significant genomic associations with Biotypes in Transcriptome-Wide Association Study (TWAS) of gene expression in adult brain and fetal brain, and of gene isoforms. TWAS inflation was successfully controlled by inclusion of genotype Principal Components in the association analyses. Biotypes and Biotype-related diagnosis distributions differ between African American and European ancestries.
Laparoscopic debulking plus HIPEC for gastric cancer in Colombia: Our first case
Authors: Rojas-Sierra Juliana , Moreno-Salamanca maria andrea , Vivero Alvaro Restrepo-de , Flórez-Castro Juan Pablo 
Published: February 2024

Abstract
Cytoreductive surgery with intraperitoneal hyperthermic chemotherapy via a moderately invasive technique is a procedure used for treating colon and ovarian neoplasms, and this approach has widely documented benefits in this area. However, in patients with gastric adenocarcinoma, the potential benefit of this approach has not been fully demonstrated, and little evidence is available. This report describes a patient with gastric cancer who underwent cytoreduction and HIPEC and the perioperative management of this patient, with emphasis on the intraoperative course from an anesthetic point of view and the immediate and early postoperative follow-up. This type of report will generate knowledge documenting behaviors and outcomes in this particular population that can potentially benefit from this therapy.
The Effect of Health Belief Model-Based Training on the Self-Compassion and Self-Efficacy of Premenopausal Women
Authors: Rezaei Elham , Maqsoud Zeinab Mirzaei , Moghadam Zahra Behboudi 
Published: February 2024

Abstract

Introduction: The premenopausal period causes many mental and physical problems in women due to hormonal changes. Education can be effective in adapting to this transitional period. This study aimed to assess the effect of health belief model-based training on the self-compassion and self-efficacy of premenopausal women.
Method: This randomized clinical trialincluded 90 Iranian women (45 intervention and 45 control) in their premenopausal period (40-50 years old), referred to comprehensive health centers in 2021. The intervention group was trained in four sessions using Skype software based on dimensions of the health belief model. The primary and key secondary outcomes were self-efficacy and self-compassion, which were assessed using questionnaires three times: before, immediately, and one month after intervention. The data were analyzed with SPSS 27 using the ITT method.
Result: The results showed that most women in each group were aged 45-50. According to the results, immediately and one month after the intervention, self-efficacy (MD(SDD):43.91(0.83);P<0.001), self-compassion(MD (SDD):59.46(0.83) ;P<0.001), or the total score of the health belief model (MD (SDD):58.12(0.81) ;P<0.001)were significantly different between the two groups .
Conclusion: This study showed that the level of self-efficacy and self-compassion of premenopausal women increased after education based on the health belief model.
Association between Stress Hyperglycemia Ratio and Functional Outcomes in Patients with Acute Ischemic Stroke
Authors: Xiao Shiyan , Gao Maofeng , Hu Shoudi , Cao Simin , Teng Liting , Xie Xiaohua 
Published: February 2024

Abstract

Objective: This study aimed to evaluate the association between stress hyperglycemia ratio (SHR) and poor functional outcomes at 90 days in patients with acute ischemic stroke (AIS).
Methods: Retrospective collection of 1988 patients with AIS admitted to two hospitals in the Shenzhen area between January 2022 and March 2023. A total of 1255 patients with Fasting Blood-glucose (FBG) and hemoglobin A1c (HbA1C) values at admission were included in this analysis. SHR, measured by FBG/HbA1C, was evaluated as both a tri-categorical variable (Tertile 1: ≤0.83; Tertile 2: 0.84 -0.95; Tertile 3: ≥0.96). The outcome was poor functional outcomes (modified Rankin Scale [mRS] score 2-6) at 90 days. We performed univariate analysis, multiple equation regression analysis, stratified analysis, and interactive analysis.
Results: Compared with patients in the lowest tertile of SHR, the highest tertile group had significantly lower odds of achieving poor functional outcomes (adjusted odds ratio, OR=2.84, 95% CI: 2.02-3.99, P<0.0001) at 90 days after adjusting for potential covariates. Similar results were observed after further adjustment for white blood cell count, neutrophil count, lymphocyte count, fasting blood glucose, stroke type, intravenous thrombolytic therapy, baseline Glasgow score, and baseline NIHSS score.
Conclusion: Stress hyperglycemia ratio, as measured by the FBG/HbA1C, was associated with an increased odds of achieving poor functional outcomes in patients with AIS at 90 days.