bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long‐term follow‐up of patients with superficial transitional cell carcinoma of the urinary bladder treated by intravesical mitomycin C
Authors: Pavlotsky Abraham , Eidelman Abraham , Barak Frida , Walach Natalio , Horn Yoav 
Published: February 2007

AbstractProphylactic intravesical chemotherapy (IVC) reduces recurrence rates of superficial transitional cell carcinoma (TCC) of the urinary bladder. The patient cohort existed of 86 individuals (stage TaNOMO or T1N0M0) superficial carcinoma of various grades of malignancy. Following initial transuretheral resection or diagnostic cystoscopy, mitomycin C (MMC), 20 mg dissolved in 50 ml saline, was instilled intravesically by catheter over 1 hr at 2‐week intervals, initially and then four more times followed by diagnostic cystoscopy (one course = 12 weeks). Two similar courses were administered thereafter for a total period of 36 weeks. For patients in remission, installations continued in monthly fractionations for 9 more months (cystoscopy every 3 months) and then at 2‐month intervals for 12 more months (cystoscopy every 6 months). When cystoscopy revealed recurrence, IVC was repeated from the beginning. No symptoms of MMC‐related toxicity were observed. Cystoscopic follow‐up evaluations showed a complete response rate of 84% at 3 years and 81 % at 5 years after initial therapy. Twenty‐seven patients who had not responded to previous treatment with other drugs responded to MMC. © 1995 Wiley‐Liss, Inc.
Absorption cytometric dna analysis of sections of gastric carcinomas and a comparison with cytofluorometry of single‐cell suspensions and flow cytometry
Authors: Haraguchi Masaru , Kakeji Yoshihiro , Orita Hiroyuki , Korenaga Daisuke , Maehara Yoshihiko , Sugimachi Keizo 
Published: February 2007

AbstractMeasurements were made of cellular deoxyribonucleic acid (DNA) content in paraffin‐embedded materials from 44 gastric carcinomas, using three different methods; static cytometric light absorbance technique using tissue sections (SCM‐abs), static cytometric fluorescence technique using single‐cell suspensions (SCM‐flu), and flow cytometry (FCM). The DNA ploidy determined by SCM‐abs was grouped into low or high ploidy according to dispersion on the DNA histogram, and the DNA ploidy determined by SCM‐flu and FCM was grouped into diploidy or aneu‐ploidy, according to the peak DNA value. Accord between SCM‐abs and SCM‐flu or between SCM‐abs and FCM was confirmed when low ploidy by SCM‐abs showed diploidy by SCM‐flu or FCM and high ploidy by SCM‐abs showed aneuploidy by SCM‐flu or FCM. An incomplete but good accord of DNA ploidy was obtained with these methods. © 1995 Wiley‐Liss, Inc.
Benign salivary gland tumors: A cytogenetic study of 21 cases
Authors: Martins Carmo , Fonseca Isabel , Félix Ana , Roque Lúcia , Soares Jorge 
Published: February 2007

AbstractCytogenetic findings of 21 benign salivary gland tumors, including 14 pleomorphic adenomas, 5 Warthin's tumors, 1 myoepithelioma, and 1 cystadenoma, are reported. The present study confirms that pleomorphic adenomas characteristically have highly specific rearrangements involving only a few chromosome regions (3p21, 8q12 and 12q13–15) which suggests their specific role in the mixed tumors genesis. Warthin's tumors also show nonrandom numerical and structural alterations that were concurrent in one of the cases studied. To our knowledge no cytogenetic data are available in myoepitheliomas and cystadenomas. The former reveals a normal karyotype and the latter shows only clonal numerical alterations (gain of chromosomes 2 and 18). © 1995 Wiley‐Liss, Inc.
Surgical treatment of non‐small cell lung cancer in patients older than seventy years
Authors: Harvey James C. , Erdman Christopher , Pisch Julianna , Beattie Edward J. 
Published: February 2007

AbstractSurgical treatment of non‐small cell lung cancer has been reported to be associated with increased mortality, especially when pneumonectomy has been employed. A 9‐year review of 81 patients treated surgically, with a policy of avoiding pneumonectomy and using internal radiation and wedge excisions rather than lobectomy among patients with impaired reserve, resulted in an operative mortality of 4.9% compared with an overall mortality of 2.1%. Three of the four deaths were among patients older than 80 3/17 (17.6%) years so that mortality of patients 70 < age < 80 was not significantly different from overall mortality. Two of the four deaths were related to pulmonary emboli but there have been no such deaths since routine use of mini‐heparin was initiated in 1990. Five‐year survival was 42% overall, 65% for stage I, and 24% for stages II‐IIIB. We conclude that surgical treatment of patients 70 < age < 80 may be accomplished with similar mortality and survival as the overall population. Heparin prophylaxis may be especially important among patients older than 80 years. © 1995 Wiley‐Liss, Inc.
Intrapleural chemotherapy for patients with incompletely resected malignant mesothelioma: The ucla experience
Authors: Lee Jeffrey D. , Perez Sol , Wang He‐Jing , Figlin Robert A. , Holmes E. Carmack 
Published: February 2007

AbstractFrom 1986 to 1993, 15 patients with malignant pleural mesothelioma were treated by pleurectomy/decortication and intrapleural cisplatin (100 mg/ m2) and cytosine arabinoside (1,200 mg). All patients were without known extrathoracic disease and had a mean age of 63.5 ± 7.9 years (range 51–78); 13 were male. Histologic subtype of disease were epithelial (47%), sarcomatoid (27%), and mixed‐biphasic (27%). The major morbidity and mortality rates were 13% and 0%, respectively. The mean length of hospital stay was 6.5 ± 2.1 days. Postoperatively, adjuvant chemotherapy and radiation therapy were given to 46% and 73% of the patients respectively. Median survival from date of treatment was 11.5 months. Those patients with an epithelial histologic subtype experienced significantly improved survival compared to those of sarcomatoid subtype (P = 0.024). Whether adjuvant chemotherapy or radiation therapy were given had no significant effect on survival. These data suggest that although this treatment regimen can be administered with very limited morbidity and no mortality, the role of this approach in the treatment of malignant pleural mesothelioma appears limited and cannot currently be recommended. © 1995 Wiley‐Liss, Inc.
Single‐treatment skin tightening by radiofrequency and long‐pulsed, 1064‐nm Nd: YAg laser compared
Authors: Key Douglas J. 
Published: February 2007

AbstractBackground and ObjectiveTo compare single‐treatment facial skin tightening achieved with the current radiofrequency (RF) protocol with single‐treatment tightening achieved with the long‐pulsed, 1064‐nm Nd:YAG laser.Study Design/Materials and MethodsA total of 12 patients were treated with RF energy on one side of the face and laser energy on the other. Results were evaluated on a numerical scale (0–12 with 12 = greatest enhancement) from pre‐ and posttreatment photographs by a blinded panel.ResultsUpper face improvement (posttreatment score minus pretreatment score) was essentially the same on both sides (30.2 and 31.3% improvement for laser and RF, respectively, P = 0.89). Lower face improvement was greater in the laser‐treated side (35.7 and 23.8% improvement for laser and RF, respectively), but the difference was not significant (P = 0.074). Overall face improvement was significantly greater on the laser‐treated side (47.5 and 29.8% improvement for laser and RF, respectively, P = 0.028).ConclusionA single high‐fluence treatment with the long‐pulse 1064‐nm Nd:YAG laser may improve skin laxity more than a single treatment with the RF device. Further controlled split‐face or very large non‐self controlled studies are needed to conclusively determine the relative efficacies of the two technologies. Lasers Surg. Med. 39:169–175, 2007. © 2007 Wiley‐Liss, Inc.
Laser surgery of port wine stains using local vaccum pressure: Changes in calculated energy deposition (Part II)
Authors: Franco Walfre , Childers Michael , Stuart Nelson J. , Aguilar Guillermo 
Published: February 2007

AbstractBackground and ObjectivesApplication of local vacuum pressure to human skin during laser irradiation results in less absorption in the epidermis and more light delivered to targeted vessels with an increased blood volume. The objective of the present numerical study is to assess the effect of applying local vacuum pressure on the temperatures of the epidermis and small vessels during port wine stain (PWS) laser treatment.Study Design/ Materials and MethodsMathematical models of light deposition and heat diffusion are used to compute absorbed energy and temperature distributions of skin and blood vessels with different diameters (10–60 µm) at various depths (200–800 µm) exposed to laser irradiation under atmospheric and vacuum pressures.ResultsUnder 50 kPa (15 in Hg) vacuum pressure, peak temperatures at the inner walls of small diameter vessels (10–30 µm) located 200–300 µm below the skin surface are ≈10°C higher than those under atmospheric pressure, and peak temperatures in the epidermis of patients with skin phototype II are ≈5°C lower. In patients with darker skin phototype (IV), the peak temperature at the inner wall of a 10 µm diameter vessel located 200 µm below the skin surface is ≈5°C higher than that under atmospheric pressure, and the peak temperature in the epidermis is ≈10°C lower.ConclusionsAdditional energy deposition in a larger blood volume permits higher temperatures to be achieved at vessel walls in response to laser irradiation. While more energy is deposited in every vessel, temperature gains in small diameter vessels (10–30 µm) are greater, increasing the likelihood of irreversible thermal damage to such vessels. In addition, temperatures in the epidermis decrease because less energy is absorbed therein due to reduced epidermal thickness and concentration of melanin per unit area. Lasers Surg. Med. 39:118–127, 2007. © 2007 Wiley‐Liss, Inc.
The 1,450‐nm diode laser reduces sebum production in facial skin: A possible mode of action of its effectiveness for the treatment of acne vulgaris
Authors: Perez‐Maldonado Adrian , Rünger Thomas M. , Krejci‐Papa Niels 
Published: February 2007

AbstractBackground and ObjectivesOver the last several years, several light‐based systems have been employed for the treatment of acne vulgaris. The 1,450‐nm diode laser has been shown to improve acne, and this has been suggested to be due to effects on sebaceous glands. However, an effect on sebum production has not been demonstrated. The objective of this study was to evaluate if the 1,450‐nm diode laser indeed reduces sebum production.Study Design/Materials and MethodsEight patients with a history of acne were recruited and treated with the 1,450‐nm diode laser on the right side of the nose over a 6‐week period, for a total of three treatments. Sebum production was quantified using the Sebutape method.ResultsThe number of sebum‐producing follicles was reduced by 8.5 and 16.7% at weeks 4 and 6, respectively (P<0.05). A significant reduction in total collected sebum (−18%) was observed at week 6.ConclusionThis data suggests that the clinical effectiveness of the 1,450‐nm diode laser may be based, at least in part, on its effects on sebaceous glands, with subsequent reduction in sebum production. Lasers Surg. Med. 39:189–192, 2007. © 2007 Wiley‐Liss, Inc.
Study of leukocyte kinetics in acute myelocytic leukemia utilizing chromium‐51
Authors: Rosen Peter J. , Eyre Harmon J. , Lilien David L. , Perry Seymour 
Published: February 2007

AbstractLeukocyte kinetic studies using chromium‐51 were performed in four patients with acute myelocytic leukemia (AML). Intravascular leukocyte survival was prolonged in comparison with granulocyte survival in normal subjects. Significant splenic pooling occurred in three patients, none of whom had splenomegaly. In one patient studied, circulating leukemic cells were shown to return to the bone marrow. The prolongation of intravascular leukocyte survival in AML in relapse, as in chronic myelocytic leukemia, probably depends on several factors including the presence of immature leukemic cells and the recycling of these cells from the spleen and bone marrow.
Adriamycin: A new effective agent in the therapy of disseminated sarcomas
Authors: Benjamin Robert S. , Wiernik Peter H. , Bachur Nicholas R. 
Published: February 2007

AbstractThirty‐six patients with disseminated sarcomas were treated with adriamycin according to an intermittent single high‐dosage schedule based on our prior pharmacologic observations. The dose of 60 mg/M2 IV q 3 weeks was reduced 50‐75% in the presence of liver disease. Complete remission occurred in 9%, partial remission in 32%, and improvement in 21% for median durations of 37, 18, and 15 weeks, respectively. Survival was prolonged in responding patients. Hematologic suppression was mild in the absence of liver disease or prior extensive radiotherapy. Congestive heart failure, a well‐known long‐term complication of therapy with anthracycline drugs, occurred in two out of four patients who had cumulative doses of 600 mg/M2 or more. Mucous membrane toxicity was not observed. Adriamycin is an effective new agent in the therapy of disseminated sarcomas and can be used with relative safety by following pharmacologic principles.
Combination chemotherapy based on a model of cell recruitment by partial synchronization
Authors: Pouillart P. , Weiner R. , Schwarzenberg L. , Misset J. L. , Oldham R. , Amiel J. L. , Mathé G. 
Published: February 2007

AbstractA noncomparative, phase II clinical trial on chemotherapy of leukemias and solid tumors has been undertaken. It has been attempted: (a) to synchronize cells by a first administration of an M‐dependent agent (vincristine or VM 26) which blocks them during the mitotic phase (M) (this has been verified by the mitotic index), from where they start again to go into the other phases of the cycle, more or less at the same time (this has been verified by the labeling index) and (b) to destroy a greater number of cells by a second administration of cycle‐dependent or phase‐dependent agent(s). Remarkable results have been obtained, the most interesting one being apparently complete remissions or regressions given by the sequence of two agents in patients who during previous trials proved to be resistent to both agents administered separately. The chemotherapy protocols thus composed are administered intermittently, comprising cycles with free intervals, the duration of which depends on the time of the bone marrow and blood restoration. The hematological, immunological, and visceral tolerance is, on the whole, satisfactory.
Management of acute leukemia in adults
Authors: Ellison Rose Ruth 
Published: February 2007

AbstractThe treatment of acute leukemia in adults, while not yet as successful as that in children with regard to either remission rate or prolongation of life, can now regularly result in at least 50% responses in acute myelocytic leukemia and 70‐80% in acute lymphocytic leukemia. Intensive specific chemotherapy and supportive therapy throughout the resultant period of myelo and immuno‐suppression are necessary to achieve these remission rates. Further investigations aimed at both prolonging the remissions so obtained and at improving the response rate further are essential.
Infections in children with acute leukemia
Authors: Freeman Arnold I. , Pantazopoulos Nicholas , Decastro Leticia , Sinks Lucius F. 
Published: February 2007

AbstractTwenty children with ALL that died in 1959—1960 and 59 children with ALL that died in 1969 — 1970 were analyzed according to the infections at both their terminal illness and their initial presentations. Despite the availability of more effective agents for pseudomonas and staphylococcus, the pattern of infecting organisms at the terminal illness did not change appreciably in this decade. E. coli, pseudomonas, staphylococcus, and candida were the principal organisms involved as a cause of death.Thirty‐five of these 79 patients were febrile when they initially presented, prior to the institution of chemotherapy. Seven of the 35 patients (20%) had proved infections. It appears that the fever in the majority of patients at their initial presentations was noninfectious in origin.In 1969–1970, 13 pulmonary aspirates were performed to aid in the etiological diagnosis of diffuse interstitial pneumonia. Only a single case (8%) of pneumonia due to pneumocystis carinii was detected, and it is our suspicion that the majority of these interstitial pneumonias were viral in origin.
Serum vitamin B12‐binding proteins in a case of eosinophilic leukemia
Authors: Coltman Charles A. , Panettiere Frank , Carmel Ralph 
Published: February 2007

AbstractA patient with subacute eosinophilic leukemia is presented, with full recognition of the controversy surrounding that entity. Serum vitamin B12 and B12 ‐binding protein studies and simultaneous complete blood counts were done before and during 6 months of high‐dose, intermittent combination chemotherapy. The patient presented with extremely high levels of serum vitamin B12, unsaturated B12‐binding capacity, and transcobalamin I, all of which resembled the highest values seen in chronic myelogenous leukemia. Serial studies, during and after remission induction, showed a precipitous fall of serum vitamin B12 and unsaturated B12‐binding capacity to normal levels. The data show that transcobalamin I levels, which eventually reached low‐normal range, correlate best with the level of circulating and bone marrow eosinophils. Transcobalamin II and serum third binder appeared to be normal throughout the patient's course. The B12‐binding protein abnormalities are not considered diagnostic of eosinophilic leukemia.
The influence of chemotherapy on the prognosis of rhabdomyosarcoma
Authors: Ortega Jorge A. , Rivard Georges E. , Isaacs Hart , Hittle Robert E. , Hays Daniel M. , Pike Malcolm C. , Karon Myron R. 
Published: February 2007

AbstractA study of 77 consecutive cases of childhood rhabdomyosarcoma treated initially at the Children's Hospital of Los Angeles from 1950 to 1972 demonstrated an impressive improvement in survival of patients when intensive chemotherapy was combined with surgery and radiation therapy. The major improvement in survival occurred in Stage II and Stage III disease. Eight out of 9 patients with a primary lesion of the lower extremities developed intra‐abdominal disease. A general approach for treatment of Stage II, III, and IV rhabdomyosarcoma is proposed which involves intensive chemotherapy, following biopsy, as the principle treatment, with radiation and surgery used as adjuvants.
Usefulness of cytosine arabinoside (NSC‐63878) and prednisone (NSC‐10023) in refractory childhood lymphoblastic leukemia
Authors: Nesbit Mark E. , Sonley Marilyn , Hammond Denman 
Published: February 2007

AbstractOne hundred forty‐three children with refractory lymphoblastic and undifferentiated leukemia (ALL/AUL) were treated with cytosine arabinoside (Ara‐C) and prednisone (Pred). The dose and duration of Ara‐C was escalated during induction depending on the response seen in the peripheral blood and/or bone marrow. For those achieving a remission, Ara‐C was also used to determine its maintenance capabilities. Of the 143 children, 79 attained a clinical remission, 45 having a complete bone marrow remission and 34 having a partial remission. Maintenance of remission with twice weekly Ara‐C was short and did not appear to depend on the amount of Ara‐C given during induction. The major toxicity of Ara‐C was myelosuppression.
Hodgkin's disease in children
Authors: Shah N. K. , Freeman A. I. , Friedman M. , Stutzman L. , Gaeta J. , Rao A. , Sinks L. F. 
Published: February 2007

AbstractFrom 1921 to 1973, 106 children with Hodgkin's disease under the age of 17 years were seen at Roswell Park Memorial Institute and were analyzed retrospectively. Evaluation was separated into three eras: 1921–1949 (early era), 1950–1964 (middle era), and 1965–1973 (recent era). In the early era, suboptimal radiation therapy was employed. In the middle era, radiation therapy techniques were improved, and single‐agent chemotherapy was introduced. In the recent era, multiagent chemotherapy routines were frequently used; aggressive external megavoltage radiation therapy became routine in conjunction with improvement in staging procedures. The best survival was observed in the recent era where five‐year survival of 96% was noted in early stage disease.Favorable prognostic features included: younger age group (5–9 years), female sex, lymphocytic predominant histology, early stage disease, and complete response to therapy. Nodular sclerosing and mixed cell types had an equal prognosis. The concept of involved area radiotherapy along with combination chemotherapy appears a reasonable approach in children and should be tested in a randomized study against more extensive radiotherapy techniques in early stage disease.
Therapy of infections in neutropenic patients: Results with gentamicin in combination with cephalothin or chloramphenicol
Authors: Valdivieso Manuel , Bodey Gerald P. , Burgess M. Andrew , Rodriguez Victorio 
Published: February 2007

AbstractGentamicin in combination with cephalothin (Gent‐Ceph) or with chloramphenicol (Gent‐Chloro) was utilized in the treatment of 55 infections occurring in 49 cancer patients. Responses were obtained in 78% of the infections treated with Gent‐Ceph and in 64% of those treated with Gent‐Chloro. Pneumonia and septicemia were the most common infections in this study. Among the cases of pneumonia, 64% responded to Gent‐Ceph and 67% to Gent‐Chloro. Among the cases of septicemia, 88% responded to Gent‐Ceph and 50% to Gent‐Chloro. All of the identified organisms producing infection were gram‐negative bacilli. Of these, E. coli was the most common. All organisms were resistant to cephalothin in vitro, and only 41% of them were resistant to chloramphenicol. However, resistant organisms responded significantly better to the Gent‐Ceph combination (p < 0.025). Also, response to therapy among patients with severe neutropenia (< 100 neutrophils/mm3) was better for those patients treated with Gent‐Ceph (p = 0.07).The combination of gentamicin with cephalothin or with chloramphenicol did not increase the frequency of side effects expected from gentamicin alone. No significant hematological toxicity was seen among those patients treated with chloramphenicol. Gentamicin in combination with cephalothin or chloramphenicol is an effective and safe antibiotic combination against gram‐negative bacilli infections occurring in cancer patients. The efficacy of Gent‐Ceph in patients with severe neutropenia is particularly advantageous.
Acute nonlymphocytic leukemia in 171 children
Authors: Choi Sun‐I , Simone Joseph V. 
Published: February 2007

AbstractThe initial features, response to therapy, complications, cause of death, and prognostic factors of 171 consecutive children with ANLL are described and compared to historical data for adults with ANLL and for children with ALL. Major differences between children and adults with ANLL include a higher frequency of CNS leukemia and a lower frequency of early deaths in the children. The most important differences between children with ANLL and ALL are the absence of a peak age of incidence in ANLL and the far better response to therapy in ALL. Among features present at 100,000/mm3 or above, and no palpable hepatomegaly had significantly longer survivals, while patients with platelet counts below 10,000/mm3 had significantly shorter survivals. The frequency and duration of remission were significantly better with three protocols used since 1968 than previously. However, even with these protocols, the results were far from satisfactory, with a complete remission frequency of 66%, a median duration of hematological remission of 6 months, and a median duration of survival of 10 months. The striking contrast of these results in childhood ANLL with current results in childhood ALL underscores the need for novel, imaginative therapeutic approaches for ANLL.