bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract SY03-03: Thinking outside the chromosome: Interrogating epigenetic mechanisms in noncanonical chromatin species
Authors: David Yael 
Published: April 2024

Abstract
The epigenetic regulation of DNA-templated processes is intricately tied to numerous events that determine cell phenotype and fate. The abrogation of epigenetic cascades drives various disease states, including cancer. Many of these pathological phenomena involve major chromosomal arrangements that can include the generation of non-canonical chromatin structures existing in the primary nuclei or encapsulated in spatially distinct micronuclei. Recently, we undertook a mechanistic approach to investigate the properties of unique non-chromosomal structures, revealing significant epigenetic contributions to their regulation. We found that micronuclei, the result of chromosomal instability in cancer, assume altered epigenetic landscapes upon departure from the nucleus. Moreover, chromosomes sequestered in micronuclei retain the epigenetic "scars" after reintegration into the primary nucleus, contributing to epigenetic reprogramming and heterogeneity in cancer. Additionally, we turned our attention to the Hepatitis B Virus' (HBV) covalently closed circular DNA (cccDNA) minichromosome, which forms from viral DNA and human histones following infection. We found that chromatinization drives the expression of the key viral oncogene, HBx, and thus promotes viral infection. Elucidating this new mechanism enabled us to halt infection by inhibiting histone remodeling, creating a potential first-in-class therapy for HBV. These exciting findings demonstrate the key role of chromatin in biomedical events and how a fundamental understanding of these processes can lead to the identification of new therapeutic avenues.
Citation Format: Yael David. Thinking outside the chromosome: Interrogating epigenetic mechanisms in noncanonical chromatin species [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 2 (Late-Breaking, Clinical Trial, and Invited Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(7_Suppl):Abstract nr SY03-03.
Abstract SY34-01: Plasticity, dormancy, and glycosylation of circulating tumor cell clusters in response to therapy
Authors: Liu Huiping 
Published: April 2024

Abstract
Cellular plasticity and stemness properties enable dynamic changes of circulating tumor cells (CTCs) during cancer dissemination, such as aggregation or cohesion of single CTCs into multicellular CTC clusters with 20-100 times higher metastatic propensity than the singles. Our work demonstrated that stemness glycoproteins on breast cancer stem cells, such as CD44, CD81, and ICAM1 drive CTC aggregation in metastatic breast cancer, such as triple negative breast cancer (TNBC). To determine the glycosylation patterns in CTCs and its association with clinical outcomes, we established multiple CTC analysis approaches including CellSearch, flow cytometry, and immunohistochemistry using patient blood and tissue sections collected at the pre-treatment baseline and after-therapy timepoints. We found that chemotherapy-evasive CTC clusters are relatively quiescent with a specific loss of terminal sugar residues α2,6-sialic acids in glycoproteins. CTCs showed dynamic hypo-sialylation in the blood with loss of the sialyl-transferase ST6GAL1, promoting CTC cluster formation with cellular quiescence (proliferative dormancy) and evading chemotherapy in breast cancer. Seeded tumor cells regained ST6GAL1 to enable metastatic colonization. Many adhesion proteins and stemness drivers as glycoprotein substrates of ST6GAL1 drive CTC clustering and metastatic seeding. Neutralizing antibodies against these clustering drivers inhibit CTC cluster formation and improve therapy response, thereby blocking lung metastasis in TNBC.
Citation Format: Huiping Liu. Plasticity, dormancy, and glycosylation of circulating tumor cell clusters in response to therapy [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 2 (Late-Breaking, Clinical Trial, and Invited Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(7_Suppl):Abstract nr SY34-01.
Speed control for traction motor of urban electrified train in field weakening region based on backstepping method
Authors: Thu Anh An Thi Hoai , Tung Ngo Manh 
Published: April 2024

Tractor motors always operate in the speed region higher than rated speed, but is limited to the module of the stator current, stator voltage vectors. Additionally, mathematical model of traction motor has shown nonlinearity through the product of the state variables 𝑖𝑠𝑑, 𝑖𝑠𝑞 with the input variable 𝜔𝑠:𝜔𝑠𝑖𝑠𝑞, 𝜔𝑠𝑖𝑠𝑑. Therefore, this paper focuses on the study of speed control of traction motors in weakening field region while optimizing torque control, and choosing the backstepping method in designing speed–flux controller in order to solve the nonlinear structure. The simulation results of the responses: speed, torque, power, and flux performed on MATLAB/Simulink software with parameters collected from metro Nhon-Hanoi Station, Vietnam have proven the correctness in theoretical research.
New control scheme for a dynamic voltage restorer based on selective harmonic injection technique with repetitive controller
Authors: Tapre Pawan C. , Thakre Mohan P. , Pawase Ramesh S. , Thorat Jaywant S. , Dahigaonkar Dipak J. , Mapari Rahul G. , Kadlag Sunil Somnath , Khule Shridhar 
Published: April 2024

Repetitive controller and selective harmonic injection technique (SHI) in medium and low voltage distribution networks improve dynamic voltage restorer (DVR) DC bus voltages as well as nullify power quality (PQ) problems. DVRs use sinusoidal pulse width modulation (SPWM) firing control, but DC bus use seems to be limited, affecting density, cost, and power packaging. By adding 1/6th of the 3rd harmonic waveform to the basic waveform, SPWM yields the developed model. According to the findings, 15% of DC bus usage improves and produces high voltage AC. Nevertheless, just control systems perturb PQ. The proposed controller uses feed forward and feedback to enhance transient response and justify stable zero error. 3rd third harmonic injection pulse width modulation (THIPWM) improves total harmonic distortion (THD) in the proposed scheme. Power system computer aided design (PSCAD) simulation produced high accuracy for THIPWM and repetitive controllers.
Cost-aware optimal resource provisioning Map-Reduce scheduler for hadoop framework
Authors: Bhaskar Archana , Ranjan Rajeev 
Published: April 2024

<p><span lang="EN-US">Distributed data processing model has been one of the primary components in the case of data-intensive applications; furthermore, due to advancements in technologies, there has been a huge volume of data generation of diverse nature. Hadoop map reduce framework is responsible for adopting the ease of deployment mechanism in an open-source framework. The existing Hadoop MapReduce framework possesses high makespan time and high Input/Output overhead and it mainly affects the cost of a model. Thus, this research work presents an optimized cost aware resource provisioning MapReduce model also known as the cost-effective resource provisioning MapReduce (CRP-MR) model. CRP-MR model introduces the two integrated approaches to minimize the cost; at first, this model presents the optimal resource optimization and optimal Input/Output optimization cleansing in the Hadoop MapReduce (HMR) scheduler. CRP-MR is evaluated considering the bioinformatics dataset and CRP-MR performs better than the existing model. </span></p>
Brain magnetic resonance imaging image classification for Alzheimer's disease and its hardware acceleration
Authors: A. Sujathakumari Bettadapura , Patil Kulkarni Sudarshan , Hallikeri Vikas 
Published: April 2024

<span lang="EN-US">Alzheimer's is a progressive neurodegenerative disorder and is considered the sixth leading cause of death after cancer and heart attack. Early detection and diagnosis provide individuals to go through a wider variety of clinical trials and get multiple medical benefits. Research on the application of deep learning and machine learning to the early detection of Alzheimer's disease has recently gained considerable attention. In this paper, we propose a deep learning classification framework to classify the individual with different progression stages of Alzheimer's disease such as mild cognitive impairment (MCI) and cognitive normal (CN). The dataset from Alzheimer’s disease neuroimaging initiative (ADNI) is considered in this paper which is a multisite having collection of Neuroimaging data for researchers. Structural magnetic resonance imaging (MRI) images are considered from the ADNI data set and feature extraction is done using a 2D discrete wavelet transform. 97% of data reduction is achieved during data pre-processing. The algorithm is trained and validated. The algorithm is accelerated in Nvidia Tx2 graphics processing unit (GPU) to get the better throughput. The result shows our algorithm outperforms the other deep learning algorithms with 91.56% accuracy. </span>
Optimal economic environmental power dispatch by using artificial bee colony algorithm
Authors: Hassan Elia Erwani , Noor Hanan Izzati Mohd , Bin Hashim Mohd Ruzaini , Sulaima Mohamad Fani , Bahaman Nazrulazhar 
Published: April 2024

<span>Today, most power plants worldwide use fossil fuels such as natural gas, coal, and oil as the primary resource for energy reproduction primarily. The new term for economic environmental power dispatch (EEPD) problems is on the minimum total cost of the generator and fossil fuel emissions to address atmosphere pollution. Thus, the significant objective functions are identified to minimize the cost of generation, most minor emission pollutants, and lowest system losses individually. As an alternative, an Artificial Bee Colony (ABC) swarming algorithm is applied to solve the EEPD problem separately in the power systems on both standard IEEE 26 bus system and IEEE 57 bus system using a MATLAB programming environment. The performance of the introduced algorithm is measured based on simple mathematical analysis such as a simple deviation and its percentage from the obtained results. From the mathematical measurement, the ABC algorithm showed an improvement on each identified single objective function as compared with the gradient approach of using the Newton Raphson method in a short computational time.</span>
Evaluating the machine learning models based on natural language processing tasks
Authors: Meeradevi Meeradevi , B. J. Sowmya , B. N. Swetha 
Published: April 2024

<span lang="EN-US">In the realm of natural language processing (NLP), a diverse array of language models has emerged, catering to a wide spectrum of tasks, ranging from speaker recognition and auto-correction to sentiment analysis and stock prediction. The significance of language models in enabling the execution of these NLP tasks cannot be overstated. This study proposes an approach to enhance accuracy by leveraging a hybrid language model, combining the strengths of long short-term memory (LSTM) and gated recurrent unit (GRU). LSTM excels in preserving long-term dependencies in data, while GRU's simpler gating mechanism expedites the training process. The research endeavors to evaluate four variations of this hybrid model: LSTM, GRU, <a name="_Hlk158992630"></a>bidirectional long short-term memory (Bi-LSTM), and a combination of LSTM with GRU. These models are subjected to rigorous testing on two distinct datasets: one focused on IBM stock price prediction, and the other on Jigsaw toxic comment classification (sentiment analysis). This work represents a significant stride towards democratizing NLP capabilities, ensuring that even in resource-constrained settings, NLP models can exhibit improved performance. The anticipated implications of these findings span a wide spectrum of real-world applications and hold the potential to stimulate further research in the field of NLP. </span>
Predicting tidal level in tropical Eastern Bintan waters using residual long short-term memory
Authors: Syakti Agsanshina Raka , Rhamadhan Syahri , Laziola Ghora , Pahrizal Pahrizal , Apdillah Dony , Ritha Nola 
Published: April 2024

<span lang="EN-US">The sea brings many benefits for society, especially for a maritime country such as Indonesia. The potential in various sectors is limited only by the willingness of a party to invest in it. One such investment is in learning the knowledge and information that can be gathered from the sea, and even predicting its behavior with enough data. Using a residual LSTM algorithm, we will predict the tidal level in eastern Bintan island, a tropical island on the tip of Malay peninsula. The dataset is acquired from two sensor points in eastern Bintan coast from July 2018 to June 2019 for a span of one year, giving a total of 7,961 data points. The residual LSTM model consists of a residual wrapper with two consecutive LSTM layers and one dense layer. The model is also compared with variations of LSTM and RNN models. The result of the residual LSTM model has an MAE value of 0.1495 cm and an RMSE value of 0.3353 cm, compared to the baseline model’s 1.1148 cm and 1.4107 cm respectively. The model also has an RMSE value improvement of 76.23% compared to the base model.</span>
Influence of graded levels of maize distillers dried grains with solubles (mDDGS) on the performance, digestive tract development and carcass characteristics of broilers
Authors: Ravindran V. , Singh Y. 
Published: April 2024

Abstract
The present study investigated the feeding value of maize distillers dried grains with solubles (mDDGS) for broiler chickens. As the first step, the nutrient composition, apparent metabolisable energy (AME) and apparent ileal amino acid digestibility of mDDGS were determined. These values were used to formulate iso-nutrient and isocaloric diets to evaluate the influence of graded levels of mDDGS on broiler performance, digestive tract development and carcass characteristics. Five maize-soybean based diets containing 0 or 5, 10, 15 and 20% of mDDGS, were formulated and cold-pelleted at 65 °C. Each diet was offered ad libitum to six replicates (eight birds per replicate cage) during starter (day 1–21) and finisher (day 22–35) phases. The mDDGS was analysed to contain (% dry matter (DM) basis): CP, 27.8; total non-starch polysaccharides, 28.6 and soluble non-starch polysaccharides, 5.6. The AME was determined to be 10.23 MJ/kg DM. The average ileal digestibility coefficient of indispensable AA was 0.826. The Inclusion of 20% mDDGS resulted in poorer (P < 0.05) feed per gain (quadratic effect, P < 0.05) during the starter period, but no negative effects (P > 0.05) were observed finisher period and the overall production period (day 1–35). Feed intake and feed per gain (linear effect, P < 0.05) decreased with increasing inclusions of mDDGS during finisher period and overall period. A tendency (P = 0.06) for linear improvement in excreta quality was observed with increasing inclusion levels of mDDGS. Relative digestive tract weights and carcass and breast meat yields were not influenced (P > 0.05) by dietary treatments. A linear (P < 0.05) decrease was observed for the relative lengths of jejunum, ileum and the small intestine. The results indicated that, when balanced for metabolisable energy and digestible amino acids, mDDGS can be incorporated into broiler starter and finisher diets up to 15 and 20%, respectively, with no adverse effects on live performance, carcass characteristics or excreta quality.
Historical Time and Acceleration. A Constitutive Bond
Authors: Torres Felipe 
Published: April 2024

Abstract
This manuscript addresses the link between the concept of ‘historical time’ and the thesis of the acceleration of history and society in constitutive terms. ‘Historical time’ is used as concept mainly from the eighteenth century and corresponds to a way of understanding the contemporary world as a moment in which a ‘chronology’ of time and, along with it, the appearance of a temporalized history itself, take place. Different temporal schemes support this transition: a pass from synchronicity to diachrony, the transition from iteration to the ‘event’, circularity to the linearity. In what follows, I propose to observe some implications and articulations of the ‘historical time’ and ‘social acceleration’ theses, advancing the hypothesis that they are both connected and mutual dependent.
Validating Tools to Measure Life Skills Among Adolescents in India
Authors: Mehta Nikita , Kapoor Hansika 
Published: April 2024

BACKGROUND: Life skill education is critical for developing various competencies among the adolescent population, especially in India, given the recent shift in policy focus. AIM: To examine the reliability, factor structure, and the validity of scales measuring gender attitudes, perceived self-efficacy, resilience, and problem-solving in order to assess the effectiveness of a life skill program among Indian adolescents. METHODS: Baseline data, before a life skill intervention program by Magic Bus India Foundation, were collected from over 16000 Indian adolescents between 11 and 15 years on different measures. Results from principal component analyses with pro-max rotation indicated a one-factor solution for all the scales. Further, confirmatory factor analyses indicated an excellent model fit using the diagonally weighted least squares method of estimation for the above- mentioned scales. RESULTS AND DISCUSSION: The models for each scale were gender invariant, indicating that gender attitudes, perceived self-efficacy, resilience, and problem solving were assessed similarly between boys and girls. Additionally, correlation analysis indicated a positive relationship between gender attitudes and self-efficacy, a negative relation between gender attitudes and resilience, and a negative association between self-efficacy and resilience. Implications are discussed.
The relationship between immune-related adverse events during ipilimumab monotherapy and survival outcomes among melanoma patients: A systematic review
Authors: Sheng Jason , Nayeni Manav , Malvankar Monali 
Published: April 2024

Background Ipilimumab disinhibits immune system activity which results in the elimination of malignant cells. An unintended consequence of ipilimumab therapy is off-target immune-related adverse events (irAEs). It has therefore been proposed that the incidence of irAEs is a manifestation of treatment effectiveness. The objective of this systematic review is to examine the relationship between irAEs and survivability among melanoma patients administered ipilimumab monotherapy. Methods A comprehensive search was conducted across several databases which yielded a total of 2381 studies. Clinical trials and prospective studies administering ipilimumab monotherapy to melanoma patients were included. Furthermore, there was no restriction placed on publication date. After screening, five studies were included for data extraction. The primary outcome of median overall survival (OS) and the secondary outcome of OS hazard ratio were extracted from the included studies. Results Based on qualitative analysis of the included studies, there seemed to be an association between the occurrence of non-lethal irAEs and improved survival outcomes among melanoma patients administered ipilimumab monotherapy. With that being said, the poorer survivability among patients who experienced high-grade irAEs may be the result of subsequent treatment discontinuation. Potential confounders such as corticosteroid use should be accounted for. Finally, landmark analyses may be conducted to account for immortal time bias. Conclusions The findings from this systematic review provide evidence suggesting that the incidence of irAEs is a marker of an improved anti-tumor response.
The use of frailty questionnaires in inpatients in two neurorehabilitation units in the East Midlands – A cross-sectional cohort study with follow-up to 1-year after discharge from inpatient rehabilitation
Authors: Edwards Laura , Tesorero Vina , Zonouzi Fattaneh , Santullo Piera , Owen Phoebe , Gordon Adam L 
Published: April 2024

Background: Frailty correlates with poor clinical outcomes and is not routinely assessed in neurorehabilitation inpatient settings. Methods: We recruited adults from two neurorehabilitation units. We administered six validated tools for assessing frailty and collected data around length of stay, discharge, readmission and change in rehabilitation outcome measures. Results: Seventy-eight participants aged between 31 and 84 years were recruited with a range of neurological diagnoses. Frailty prevalence ranged between 23% and 46%, depending on the scale used, with little agreement between tools. Frailty status did not correlate with age, gender, length of stay, discharge destination and rehabilitation outcome measures. One-year readmission was higher in participants rated as frail by the Frail-Non-Disabled Questionnaire, the FRESH-screening questionnaire and the Clinical Frailty Scale. Conclusion: Frailty ascertainment was variable depending on the tool used. Three frailty indices predicted readmission rate at 1 year but no other outcome measures. Therefore, frailty tools may have limited utility in this clinical population.
Endovascular revascularization of vertebrobasilar tandem occlusions in comparison to isolated basilar artery occlusions: A multi-center experience
Authors: Klail Tomas , Piechowiak Eike I. , Krug Nadja , Maegerlein Christian , Maus Volker , Fischer Sebastian , Lobsien Donald , Pielenz Daniel , Styczen Hanna , Deuschl Cornelius , Thormann Maximilian , Diamandis Elie , Heldner Mirjam R. , Kaesmacher Johannes , Mordasini Pasquale 
Published: April 2024

Background Acute basilar artery occlusion (BAO) is a severe disease that is associated with an 85% mortality rate if untreated. Several studies have analyzed the use of mechanical thrombectomy (MT) in the different scenarios of BAO. However, the results remain conflicting and the role of MT as standard of care for vertebrobasilar tandem occlusions (VBTO) has not been confirmed. Our goal was to assess technical feasibility, safety, and functional outcome of endovascular treatment of VBTO in comparison to isolated BAO (IBAO). Methods We retrospectively reviewed all prospectively collected patients with acute BAO from six tertiary centers between September 2016 and November 2021. Patients were subsequently divided into two groups: VBTO and IBAO. Baseline data, procedural details, and outcomes were compared between groups. Results A total of 190 patients were included, 55 presenting with a VBTO and 135 with IBAO. Successful recanalization was equally common in both groups (89.1% and 86.0%). Rates of favorable functional outcome (modified Rankin Scale: 0–2) were higher in patients with VBTO compared to IBAO (36.4% vs. 25.2%, p = 0.048) and mortality was lower (29.1% vs. 33.3%). However, these associations faded after adjustment for confounders (adjusted odds ratio [aOR] 0.86, 95% CI 0.35–2.05; aOR 0.93, 95% CI 0.35–2.45). Rates of symptomatic intracranial hemorrhage did not differ between the groups (VBTO: 7.3% vs. IBAO: 4.2%; p = 0.496). Conclusion Endovascular treatment of VBTO is technically feasible and safe with similar rates of successful recanalization, favorable functional outcome, and mortality to those in patients with IBAO.