bluuebunny/crossref_metadata_2025_split huggingface dataset:
A 25-year longitudinal, comparison study of the outcome of depression
Authors: BRODATY H. , LUSCOMBE G. , PEISAH C. , ANSTEY K. , ANDREWS G. 
Published: August 2008

Background. There is still a relative paucity of information about the long-term course of depression.Methods. Consecutive patients admitted to a teaching hospital psychiatry unit with symptoms of depression, previously assessed at 6 months and 2, 5 and 15 years after index admission, were reviewed at 25 years (N = 49, including eight informants of deceased probands, of an original 145 with major depression (DEPs)). Prospective psychiatric (N = 22) and retrospective surgical (N = 50) control groups assessed after 25 years were used for comparison.Results. A further decade of follow-up confirmed the chronicity of depression. Of depressed patients (DEPs) followed for the full 25-year-period only 12% of the 49 original DEPs recovered and remained continuously well, 84% experienced recurrences, 2% experienced an unremitting course and another 2% died by suicide. Note that in the first 15-year-period 6% (9/145 DEPs) committed suicide, a further 38 died and 32 were lost to follow-up. They experienced an average of three episodes of depression over the 25 years. In the decade since the 15-year follow-up, 27% improved in clinical outcome (including four of five previously chronically depressed patients), 55% remained unchanged and 18% worsened; and the number of episodes per year declined. Patients initially diagnosed with neurotic or endogenous depression had similar long-term outcomes. The criteria for a current DSM-III-R disorder were met by 37% of DEPs, including 11% with depression or dysthymia. On the global assessment of functioning scale 78% of the DEPs had some impairment compared to 62% of psychiatric controls and 40% of surgical controls.Conclusion. Even after 25 years, severe depressive disorders appear to have poor long-term outcomes. Patients with chronic outcomes over 15 years can improve when followed over longer periods.
A twin study of genetic and environmental influences on suicidality in men
Authors: FU Q. , HEATH A. C. , BUCHOLZ K. K. , NELSON E. C. , GLOWINSKI A. L. , GOLDBERG J. , LYONS M. J. , TSUANG M. T. , JACOB T. , TRUE M. R. , EISEN S. A. 
Published: August 2008

Background. Previous studies that have examined genetic influences on suicidal behaviour were confounded by genetic vulnerability for psychiatric risk factors. The present study examines genetic influences on suicidality (i.e. suicidal ideation and/or suicide attempt) after controlling for the inheritance of psychiatric disorders.Methods. Sociodemographics, combat exposure, lifetime DSM-III-R major depression, bipolar disorder, childhood conduct disorder, adult antisocial personality disorder, panic disorder, post-traumatic stress disorder, drug dependence, alcohol dependence and lifetime suicidal ideation and attempt were assessed in 3372 twin pairs from the Vietnam Era Twin Registry who were assessed in 1987 and 1992. Genetic risk factors for suicidality were examined in a multinomial logistic regression model. Additive genetic, shared environmental and non-shared environmental effects on suicidality were estimated using structural equation modelling, controlling for other risk factors.Results. The prevalence of suicidal ideation and suicide attempt were 16·1% and 2·4% respectively. In a multinomial regression model, co-twin’s suicidality, being white, unemployment, being other than married, medium combat exposure and psychiatric disorders were significant predictors for suicidal ideation. Co-twin’s suicidality, unemployment, marital disruption, low education attainment and psychiatric disorders (except childhood conduct disorder) were significant predictors for suicide attempt. Model-fitting suggested that suicidal ideation was influenced by additive genetic (36%) and non-shared environmental (64%) effects, while suicide attempt was affected by additive genetic (17%), shared environmental (19%) and non-shared environmental (64%) effects.Conclusions. There may be a genetic susceptibility specific to both suicidal ideation and suicide attempt in men, which is not explained by the inheritance of common psychiatric disorders.
Acculturation and suicide: a case–control psychological autopsy study
Authors: LEE C.-S. , CHANG J.-C. , CHENG A. T. A. 
Published: August 2008

Background. The relationships between acculturation and suicide were investigated in East Taiwan.Methods. Psychological autopsy interviews were conducted for consecutive suicides from two native Taiwanese groups (Atayal and Ami) (N = 30 for each group); each of them was matched with two controls for age, sex and area of residence. The Taiwan Aboriginal Acculturation Scale was used to measure the extent of acculturation.Results. A lower degree of social assimilation was significantly associated with a higher risk of suicide in the Atayal and the male groups. In multivariable regression analysis, a significant effect of low social assimilation on the risk of suicide was found in Atayal and in men, even after controlling for the effects of ICD-10 depressive episode and emotionally unstable personality disorder. Meanwhile, there was a significant trend across low, moderate and high social assimilation on suicide risk in Atayal and in men.Conclusions. For the native Taiwanese, the stress from rapid acculturation into the main Chinese society is crucial to their mental health. It might be reduced through targeted social and educational programmes.
Genetic and environmental influences on premenstrual symptoms in an Australian twin sample
Authors: TRELOAR S. A. , HEATH A. C. , MARTIN N. G. 
Published: August 2008

Background. We aimed to explore the prevalence and factor structure of premenstrual symptoms in a sample of Australian twins; to investigate phenotypic associations between reported premenstrual symptoms, personality and reproductive dimensions; and to identify the relative contributions of genes and environment to premenstrual symptoms and the extent of genetic and environmental covariation with the personality trait Neuroticism and lifetime major depression.Method. Seven hundred and twenty female twin pairs (454 monozygotic and 266 dizygotic) from the Australian National Health and Medical Research Council Twin Register reported on experience of 17 premenstrual symptoms during the previous 12 months. In the same questionnaire twins also responded to questions on symptom states, and personality dimensions including neuroticism. Interview data enabling diagnosis of lifetime history of DSM-IV major depression were also available. We fitted univariate and multivariate genetic models to the data.Results. Most frequently reported symptoms were breast tenderness/pain and bloating/weight gain, followed by affective symptoms. Twelve-month prevalence was 2·4% for the combination of symptoms and functional interference meeting a very rough approximation of DSM-III-R criteria for late luteal dysphoric disorder. Principal factor analysis identified a single premenstrual (PMS) factor. Additive genetic influences (44% of total variance) were identified for PMS. Although we found genetic correlations of 0·62 between reported PMS and neuroticism, and 0·70 with lifetime major depression, 39% of the genetic variance of PMS was not explained by these factors.Conclusions. Our findings support the existence of genetic influences on premenstrual symptoms, but we were unable to distinguish between liability to symptom experience and symptom reporting. Retrospective reporting may have contributed to our finding that PMS genes were shared in part with neuroticism and liability to lifetime major depression.
The clinical epidemiology of hysteria: vanishingly rare, or just vanishing?
Authors: AKAGI HIROKO , HOUSE ALLAN 
Published: August 2008

Vanish 1. intr. To disappear from sight or become invisible, esp. in a rapid and mysterious way (Shorter Oxford English Dictionary, 1972).There is a well-known view that hysteria has virtually disappeared in the Western world. There are two versions of this argument: one is that there was never a clinical disorder that coincided with the diagnosis, and hysteria has now been reconstructed as something else (e.g. Micale, 1993). The other is that hysteria did exist but has now become much rarer than it was (most famously, Veith, 1965). According to this view, hysteria is to be found in patients from developing countries, but in Western countries it is ‘virtually a historical curiosity’ (BMJ 1976). It is the latter view that is – in our experience – most commonly held by our colleagues in general psychiatry. Yet, this opinion is not shared by those who are involved in the clinical care of patients with neurological disorders: ‘to a psychiatrist who sees patients on the medical and surgical services of a general hospital, it appears that hysteria remains a rather common phenomenon’ (Brownsberger, 1966). A number of descriptions from liaison psychiatry services support this opinion (Akagi & House, 2001). There are good reasons why it might be difficult to judge just how common (or rare) hysteria really is. Epidemiology depends on reliable case definition, case ascertainment and selection of a suitable population to study (Neugebauer et al. 1980), and each of these poses problems in the study of hysterical disorders.
Genetic and environmental contributions to cannabis dependence in a national young adult twin sample
Authors: LYNSKEY M. T. , HEATH A. C. , NELSON E. C. , BUCHOLZ K. K. , MADDEN P. A. F. , SLUTSKE W. S. , STATHAM D. J. , MARTIN N. G. 
Published: August 2008

Background. This paper examines genetic and environmental contributions to risk of cannabis dependence.Method. Symptoms of cannabis dependence and measures of social, family and individual risk factors were assessed in a sample of 6265 young adult male and female Australian twins born 1964–1971.Results. Symptoms of cannabis dependence were common: 11·0% of sample (15·1% of men and 7·8% of women) reported two or more symptoms of dependence. Correlates of cannabis dependence included educational attainment, exposure to parental conflict, sexual abuse, major depression, social anxiety and childhood conduct disorder. However, even after control for the effects of these factors, there was evidence of significant genetic effects on risk of cannabis dependence. Standard genetic modelling indicated that 44·7% (95% CI = 15–72·2) of the variance in liability to cannabis dependence could be accounted for by genetic factors, 20·1% (95% CI = 0–43·6) could be attributed to shared environment factors and 35·3% (95% CI = 26·4–45·7) could be attributed to non-shared environmental factors. However, while there was no evidence of significant gender differences in the magnitude of genetic and environmental influences, a model which assumed both genetic and shared environmental influences on risks of cannabis dependence among men and shared environmental but no genetic influences among women provided an equally good fit to the data.Conclusions. There was consistent evidence that genetic risk factors are important determinants of risk of cannabis dependence among men. However, it remains uncertain whether there are genetic influences on liability to cannabis dependence among women.
Acts of control in schizophrenia: dissociating the components of inhibition
Authors: BADCOCK J. C. , MICHIE P. T. , JOHNSON L. , COMBRINCK J. 
Published: August 2008

Background. Inhibitory deficits have been frequently reported in schizophrenia. Such deficits are usually associated with activities of prefrontal cortex and related networks. An understanding of intentional inhibitory control requires knowledge of how actions are planned and initiated and the components involved in stopping these actions.Methods. Patients with schizophrenia, a psychosis comparison group and a healthy control group participated in a visual choice reaction time (go) task and attempted to inhibit their responses to the go task when an auditory ‘stop’ signal was heard.Results. Schizophrenia patients demonstrated significantly slower response execution but the estimated speed of inhibition was not significantly different from that of healthy controls. Both patient groups were impaired in their ability to inhibit a response across a range of stop-signal delays. The poorer performance of schizophrenia patients only was related to a difficulty in reliably triggering the inhibitory response.Conclusions. Impaired response inhibition is not unique to schizophrenia. However, the nature of their problem is markedly different from that of other psychopathological groups. Possible neural mechanisms underpinning difficulties in triggering inhibitory responses and in the voluntary initiation of actions in schizophrenia are considered.
Dopamine transporter availability in symptomatic depressed patients with seasonal affective disorder and healthy controls
Authors: NEUMEISTER A. , WILLEIT M. , PRASCHAK-RIEDER N. , ASENBAUM S. , STASTNY J. , HILGER E. , PIRKER W. , KONSTANTINIDIS A. , KASPER S. 
Published: August 2008

Background. During recent years hypotheses about the pathophysiology of seasonal affective disorder/winter type (SAD) have focused monoaminergic mechanisms. There is substantial evidence that serotonergic systems play an important role. The potential role of catecholaminergic pathways has not been fully explored.Methods. Eleven drug-free, symptomatic depressed patients with SAD and 11 healthy age- and gender-matched healthy controls were invited to participate in a 123Iβ-CIT single photon emission computed tomography (SPECT) study to assess striatal density of dopamine transporters (DATs). The cerebellum was used as reference region. Ratios were calculated between mean counts in left and right striatum and cerebellum. These ratios minus 1 represent specific/non-displaceable binding and are assumed to be directly related to DAT availability at the time of binding equilibrium.Results. Displaceable 123Iβ-CIT binding in the area corresponding to the left striatum was significantly reduced in SAD patients compared to healthy controls (10·49±0·91 v. 11·95±1·54, respectively; 2-tailed P = 0·017, Mann–Whitney U test).Conclusions. These data suggest reductions in the availability of striatal DAT binding sites in untreated symptomatic depressed SAD patients. It remains unclear whether these reductions represent a primary defect or an attempt to overcome a state of possible lowered dopamine availability in the synaptic cleft during a depressive episode of SAD. However, these findings provide evidence that brain dopaminergic systems may be involved in the pathophysiology of SAD.
Waltz, Kant and systemic approaches to international relations
Authors: HARRISON EWAN 
Published: August 2008

This article compares Waltz and Kant as theorists who explicitly advocate a systemic approach to international relations. Waltz and Kant are compared with respect to their views on the nature of systemic approaches, the composition and dynamics of the international system, and the relationship between the international system and world society. It is argued that there are deep underlying similarities between their views on the nature of systemic approaches to international relations that may facilitate a much broader account of the international system. A final section examines the relevance of a Kantian view of the international system to the post-Cold War era by comparing its insights to those offered by neorealist and classical realist perspectives.…the best way to understand the writings of philosophers is to seek out the questions they were attempting to answer.
A two-fluid model for tissue growth within a dynamic flow environment
Authors: O'DEA R. D. , WATERS S. L. , BYRNE H. M. 
Published: August 2008

We study the growth of a tissue construct in a perfusion bioreactor, focussing on its response to the mechanical environment. The bioreactor system is modelled as a two-dimensional channel containing a tissue construct through which a flow of culture medium is driven. We employ a multiphase formulation of the type presented by G. Lemon, J. King, H. Byrne, O. Jensen and K. Shakesheff in their study (Multiphase modelling of tissue growth using the theory of mixtures.J. Math. Biol.52(2), 2006, 571–594) restricted to two interacting fluid phases, representing a cell population (and attendant extracellular matrix) and a culture medium, and employ the simplifying limit of large interphase viscous drag after S. Franks in her study (Mathematical Modelling of Tumour Growth and Stability. Ph.D. Thesis, University of Nottingham, UK, 2002) and S. Franks and J. King in their study (Interactions between a uniformly proliferating tumour and its surrounding: Uniform material properties.Math. Med. Biol.20, 2003, 47–89).The novel aspects of this study are: (i) the investigation of the effect of an imposed flow on the growth of the tissue construct, and (ii) the inclusion of a mechanotransduction mechanism regulating the response of the cells to the local mechanical environment. Specifically, we consider the response of the cells to their local density and the culture medium pressure. As such, this study forms the first step towards a general multiphase formulation that incorporates the effect of mechanotransduction on the growth and morphology of a tissue construct.The model is analysed using analytic and numerical techniques, the results of which illustrate the potential use of the model to predict the dominant regulatory stimuli in a cell population.
Rehabilitation and management of apraxia after stroke
Authors: van Heugten Caroline M 
Published: August 2008

IntroductionA stroke patient puts on his shoes and then tries to put on his socks over his
shoes. Entering the kitchen, this patient puts milk in the teapot, places the sugar
bowl in the oven, and tries to drink from the milk jug. This patient is most probably
apractic. Apraxia is one of the four classical neuropsychological deficits –
such as agnosia, amnesia and aphasia – causing restrictions in the ability
to carry out purposeful and learned activities. One of the first definitions of apraxia
was given by Geschwind: ‘Disorders of the execution of learned
movements which cannot be accounted for by either weakness, inco-ordination, or sensory
loss, nor by incomprehension of, or inattention to commands.’
Analysis of Genetic Interaction Maps Reveals Functional Pleiotropy
Authors: Pu Shuye , Ronen Karen , Vlasblom James , Greenblatt Jack , Wodak Shoshana 
Published: August 2008

AbstractEpistatic or genetic interactions, representing the effects of mutations on the phenotypes caused by other mutations, can be very helpful for uncovering functional relationships between genes. Recently, the Epistasis Miniarray Profile (E-MAP) method has emerged as a powerful approach for identifying such interactions systematically. As part of this approach, hierarchical clustering is used to partition genes into groups on the basis of the similarity between their global interaction profiles. Here we present an original biclustering algorithm for identifying groups of functionally related genes from E-MAP data in a manner that allows individual genes to be assigned to more than one functional group. This enables investigation of the pleiotropic nature of gene function, a goal that cannot be achieved with hierarchical clustering. The performance of our algorithm is illustrated by applying it to two E-MAP datasets and an E-MAP-like in silico dataset for the yeast S. cerevisiae. In addition to identifying the majority of the functional modules reported in these studies, our algorithm uncovers many recently documented and novel multi-functional relationships between genes and gene groups.
Moving to the Speed of Sound: Context Modulation of the Effect of Acoustic Properties of Speech
Authors: Shintel Hadas , Nusbaum Howard C. 
Published: August 2008

AbstractSuprasegmental acoustic patterns in speech can convey meaningful information and affect listeners' interpretation in various ways, including through systematic analog mapping of message‐relevant information onto prosody. We examined whether the effect of analog acoustic variation is governed by the acoustic properties themselves. For example, fast speech may always prime the concept of speed or a faster response. Alternatively, the effect may be modulated by the context‐dependent interpretation of those properties; the effect of rate may depend on how listeners construe its meaning in the immediate linguistic or communicative context. In two experiments, participants read short scenarios that implied, or did not imply, urgency. Scenarios were followed by recorded instructions, spoken at varying rates. The results show that speech rate had an effect on listeners' response speed; however, this effect was modulated by discourse context. Speech rate affected response speed following contexts that emphasized speed, but not without such contextual information.
Do Humans Really Learn AnBn Artificial Grammars From Exemplars?
Authors: Hochmann Jean‐Rémy , Azadpour Mahan , Mehler Jacques 
Published: August 2008

AbstractAn important topic in the evolution of language is the kinds of grammars that can be computed by humans and other animals. Fitch and Hauser () approached this question by assessing the ability of different species to learn 2 grammars, (AB)n and An Bn. An Bn was taken to indicate a phrase structure grammar, eliciting a center‐embedded pattern. (AB)n indicates a grammar whose strings entail only local relations between the categories of constituents. F&H's data suggest that humans, but not tamarin monkeys, learn an An Bn grammar, whereas both learn a simpler (AB)n grammar (). In their experiments, the A constituents were syllables pronounced by a female voice, whereas the B constituents were syllables pronounced by a male voice. This study proposes that what characterizes the An Bn exemplars is the distributional regularities of the syllables pronounced by either a male or a female rather than the underlying, more abstract patterns. This article replicates F&H's data and reports new controls using either categories similar to those in F&H or less salient ones. This article shows that distributional regularities explain the data better than grammar learning. Indeed, when familiarized with An Bn exemplars, participants failed to discriminate A3 B2 and A2 B3 from An Bn items, missing the crucial feature that the number of As must equal the number of Bs. Therefore, contrary to F&H, this study concludes that no syntactic rules implementing embedded nonadjacent dependencies were learned in these experiments. The difference between human linguistic abilities and the putative precursors in monkeys deserves further exploration.
The Tractable Cognition Thesis
Authors: Van Rooij Iris 
Published: August 2008

AbstractThe recognition that human minds/brains are finite systems with limited resources for computation has led some researchers to advance the Tractable Cognition thesis: Human cognitive capacities are constrained by computational tractability. This thesis, if true, serves cognitive psychology by constraining the space of computational‐level theories of cognition. To utilize this constraint, a precise and workable definition of “computational tractability” is needed. Following computer science tradition, many cognitive scientists and psychologists define computational tractability as polynomial‐time computability, leading to the P‐Cognition thesis. This article explains how and why the P‐Cognition thesis may be overly restrictive, risking the exclusion of veridical computational‐level theories from scientific investigation. An argument is made to replace the P‐Cognition thesis by the FPT‐Cognition thesis as an alternative formalization of the Tractable Cognition thesis (here, FPT stands for fixed‐parameter tractable). Possible objections to the Tractable Cognition thesis, and its proposed formalization, are discussed, and existing misconceptions are clarified.