bluuebunny/crossref_metadata_2025_split huggingface dataset:
VISTA/CTLA4/PD1 coexpression on tumor cells confers a favorable immune microenvironment and better prognosis in high-grade serous ovarian carcinoma
Authors: Jlassi Aida , Rejaibi Rim , Manai Maroua , Sahraoui Ghada , Guerfali Fatma Zahra , Charfi Lamia , Mezlini Amel , Manai Mohamed , Mrad Karima , Doghri Raoudha 
Published: April 2024

IntroductionImmunotherapy by blocking immune checkpoints programmed death/ligand (PD1/PDL1) and cytotoxic T-lymphocyte-associated protein 4(CTLA4) has emerged as new therapeutic targets in cancer. However, their efficacy has been limited due to resistance. A new- checkpoint V-domain Ig-containing suppressor of T cell activation (VISTA) has appeared, but the use of its inhibition effect in combination with antibodies targeting PDL1/PD1and CTLA4 has not been reported in ovarian cancer.MethodsIn this study, we investigated the expressions of VISTA, CTLA4, and PDL1 using immunohistochemistry (IHC)on 135 Formalin-Fixed Paraffin-Embedded (FFPE)tissue samples of High-grade serous carcinoma (HGSOC). VISTA, CTLA4, PDL1, PD1, CD8, CD4, and FOXP3 mRNA extracted from 429 patients with ovarian cancer in the Cancer Genome Atlas (TCGA) database was included as a validation cohort. Correlations between these checkpoints, tumor-infiltrating- lymphocytes (TILs), and survival were analyzed.Results and discussionCTLA4 was detectable in 87.3% of samples, VISTA in 64.7%, PD1 in 56.7%, and PDL1 in 48.1%. PDL1 was the only tested protein associated with an advanced stage (p=0.05). VISTA was associated with PDL1, PD1, and CTLA4 expressions (p=0.005, p=0.001, p=0.008, respectively), consistent with mRNA level analysis from the TCGA database. Univariate analyses showed only VISTA expression (p=0.04) correlated with overall survival (OS). Multivariate analyses showed that VISTA expression (p=0.01) and the coexpression of VISTA+/CTLA4+/PD1+ (p=0.05) were associated with better OS independently of the clinicopathological features. Kaplan-Meier analysis showed that the coexpression of the VISTA+/CTLA4+/PDL1+ and VISTA+/CTLA4+/PD1+ checkpoints on tumor cells (TCs)were associated with OS (p=0.02 and p&lt;0.001; respectively). VISTA+/CTLA4+/PD1+ in TCs and CD4+/CD8+TILswere associated with better 2-yer OS. This correlation may refer to the role of VISTA as a receptor in the TCs and not in the immune cells. Thus, targeting combination therapy blocking VISTA, CTLA4, and PD1 could be a novel and attractive strategy for HGSOC treatment, considering the ambivalent role of VISTA in the HGSOC tumor cells.
Serious adverse drug events associated with psychotropic treatment of bipolar or schizoaffective disorder: a 17-year follow-up on the LiSIE retrospective cohort study
Authors: Truedson Petra , Ott Michael , Wahlström Lisa , Lundqvist Robert , Maripuu Martin , Lindmark Krister , Lieber Ingrid , Werneke Ursula 
Published: April 2024

IntroductionMood stabilisers and other psychotropic drugs can lead to serious adverse drug events (ADEs). However, the incidence remains unknown. We aimed to (a) determine the incidence of serious ADEs in patients with bipolar or schizoaffective disorders, (b) explore the role of lithium exposure, and (c) describe the aetiology.MethodsThis study is part of the LiSIE (Lithium—Study into Effects and Side Effects) retrospective cohort study. Between 2001 and 2017, patients in the Swedish region of Norrbotten, with a diagnosis of bipolar or schizoaffective disorder, were screened for serious ADEs to psychotropic drugs, having resulted in critical, post-anaesthesia, or intensive care. We determined the incidence rate of serious ADEs/1,000 person-years (PY).ResultsIn 1,521 patients, we identified 41 serious ADEs, yielding an incidence rate of 1.9 events per 1,000 PY. The incidence rate ratio (IRR) between ADEs with lithium present and causally implicated and ADEs without lithium exposure was significant at 2.59 (95% CI 1.20–5.51; p = 0.0094). The IRR of ADEs in patients &lt;65 and ≥65 years was significant at 3.36 (95% CI 1.63–6.63; p = 0.0007). The most common ADEs were chronic lithium intoxication, oversedation, and cardiac/blood pressure-related events.DiscussionSerious ADEs related to treatment of bipolar (BD) or schizoaffective disorder (SZD) were uncommon but not rare. Older individuals were particularly at risk. The risk was higher in individuals exposed to lithium. Serum lithium concentration should always be checked when patients present with new or unclear somatic symptoms. However, severe ADEs also occurred with other mood stabilisers and other psychotropic drugs.
Increased eating disorder frequency and body image disturbance among fashion models due to intense environmental pressure: a content analysis
Authors: Bogár Nikolett , Kővágó Pál , Túry Ferenc 
Published: April 2024

IntroductionFemale fashion models are under intense occupational pressure. The present study focuses on assessing the lived experience of fashion models with regards to their dieting and exercising habits, body image perception, eating disorder-like symptoms, and experience of abuse via self-narrated reports.MethodsSeries of open questions were distributed among international fashion models (N=84, mean age=23.2 years; mean BMI=16.9) selected by convenience and snowball sampling. Models from 17 countries participated. The questions targeted models’ eating, exercising, dieting habits, body image perception, and eating disorder symptoms. The average word count of the transcripts was 2473.9 (SD = 2791.6). Thematic content analysis was performed on the transcripts. A total of 31 codes were created to address disordered eating and body image concerns.ResultsNegative body-related claims appeared in 89.3%, and positive claims in 64.3% of the models’ transcripts. Negative remarks about eating were made by 45.2% of the participants, and 23.8% positively. Control over their food intake was exercised by 78.6% of the participants and 40.5% used extreme calorie restriction. Models who talked more positively about their bodies expressed significantly more frequently extreme calorie restriction. Extreme sports habits occurred in 23.8% of the transcripts, obsessive sports habits were claimed by 11.9% of participants. Self-induced vomiting was prominent in 14.3% of the answers. Criticism from other industry members was experienced by 83.3% of the participants while 44.0% received body appreciation. Body image disorder-like symptoms were expressed by 63.1% of models. Such models mentioned significantly more often content about eating disorders and talked significantly more negatively about eating. Psychological problems were mentioned by 48.8%, whereas 16.7% took part in psychotherapy. Those who partake in therapy mentioned significantly more eating disorder content in their narratives. Abuse was mentioned by 25.0% of the models.ConclusionFashion models are experiencing increased environmental pressure to conform to the extreme slimness ideal. There is a heightened prevalence of disordered eating and other weight-controlling behaviours among fashion models to succeed in their careers. Qualitative research is crucial in understanding the more subtle dynamics in conforming to and maintaining the thin beauty ideal.
Effectiveness of interventions to improve adherence to antidepressant medication in patients with depressive disorders: a cluster randomized controlled trial
Authors: del Pino-Sedeño Tasmania , González-Pacheco Himar , González de León Beatriz , Serrano-Pérez Pedro , Acosta Artiles Francisco Javier , Valcarcel-Nazco Cristina , Hurtado-Navarro Isabel , Rodríguez Álvarez Cristobalina , Trujillo-Martín María M. ,   on behalf of MAPDep Team
Published: April 2024

AimTo assess the effectiveness of two interventions of knowledge transfer and behavior modification to improve medication adherence in patients with depressive disorders.MethodsAn open, multicenter, three-arm clinical trial with random allocation by cluster to usual care or to one of the two interventions. The intervention for psychiatrists (PsI) included an educational program based on a patient-centered care model. The intervention for patients and relatives (PtI) included a collaborative care program plus a reminder system that works using an already available medication reminder application. The primary outcome was patient adherence to antidepressant treatment assessed through the Sidorkiewicz Adherence Instrument. Secondary measures were depression severity, comorbid anxiety and health-related quality of life. Mixed regression models with repeated measures were used for data analysis.ResultsTen psychiatrists and 150 patients diagnosed with depressive disorder from eight Community Mental Health Units in the Canary Islands (Spain) were included. Compared with usual care, no differences in long-term adherence were observed in either group PsI or PtI. The PsI group had significantly improved depression symptoms (B = −0.39; 95%CI: −0.65, −0.12; p = 0.004) during the follow-up period. The PtI group presented improved depression symptoms (B = −0.63; 95%CI: −0.96, −0.30; p &lt; 0.001) and mental quality of life (B = 0.08; 95%CI: 0.004, 0.15; p = 0.039) during the follow-up period.ConclusionThe assessed interventions to improve adherence in patients with depressive disorder were effective for depression symptoms and mental quality of life, even over the long term. However, no effect on antidepressant adherence was observed.
Health risk assessment of ciprofloxacin, tetracycline, and oxytetracycline residues in raw, frozen, and boiled broiler chicken available in a local area of Bangladesh
Authors: Haque Shaila , Jamil Md. Yusuf , Khan Md. Shahinul Haque , Reza Md. Sajib Al , Esrafil Md. , Abedin Md. Zainul , Zubair Md. Abu , Sikder Md. Asaduzzaman , Bari Luthfunnesa 
Published: April 2024

IntroductionThe misuse of antibiotics in poultry farming is a global issue.ObjectiveThe focus of this study was the health risk assessment of consumers from the determination of ciprofloxacin (CIP), tetracycline (TC), and oxytetracycline (OTC) in broiler chicken in the raw, frozen, and boiled stages using solid-phase extraction, high-performance liquid chromatography, and ultraviolet detection (SPE-HPLC-UV).Materials and methodsChromatographic separation was achieved using 0.3% metaphosphoric acid and acetonitrile (1:10, v/v) for CIP at 280 nm and oxalic acid (0.01 M) and acetonitrile (1:1, v/v) for TC and OTC at 355 nm with different retention times. The method had an acceptable precision with good linearity, specificity, limit of detection, limit of quantification, accuracy, and stability.ResultsAmong a total of 252 raw samples, approximately 68.25%, 25.4%, and 7.54% contained CIP, TC, and OTC, respectively. Out of the positive raw samples, CIP exceeded the maximum residual limit (MRL) in 3.6% muscle, 14.3% liver and 17.9% skin samples, whereas TC and OTC were below the MRLs. The residual concentrations of these antibiotics were almost unchanged in frozen samples. After boiling the chicken samples, the TC and OTC residues were reduced significantly compared to CIP. Although the concentrations of CIP in boiled samples were above the MRL set by the European Union, these did not exceed the hazard index 1.ConclusionBased on these results, the exposure levels to antibiotics in broiler chicken meats may be considered to have a low risk for human health.
Sleep/wake regularity influences how stress shapes executive function
Authors: Gilmore Gabriel R. , Smith Anna L. , Dickinson Fallon B. , Crosswell Alexandra D. , Mendes Wendy Berry , Whitehurst Lauren N. 
Published: April 2024

IntroductionSleep and stress processes shape executive function. Evidence suggests that poor sleep regulation can lead to significant impairments in executive functions. Psychological stress can also directly impact a variety of executive functions, often leading to declines, but may additionally reduce executive function via its negative impact on sleep. Rates of perceived stress and poor sleep have skyrocketed in recent years. As such, it has become increasingly important to understand how daily stress exposures and sleep processes modulate executive functions.MethodsIn a remote 21-day app-based study, 227 participants completed sleep and stress assessments three times a day. They also completed three executive functioning tasks at various timepoints across the 21-day study interval that assessed cognitive inhibition (Emotional Stroop task), cognitive flexibility (Trail Making Test A and B), and working memory (Backwards Digit Span).ResultsParticipants with consistent sleep/wake schedules reported fewer acute stress events when compared to those with inconsistent sleep schedules. Those with greater sleep/wake regularity also had faster responses to self-relevant negative probes (vs. general negative and neutral) in the Stroop task. Further, variability in sleep/wake timing and reported acute stress exposures across the 21-day study interval interacted to predict performance on the Emotional Stroop task. Specifically, as the number of acute stress events experienced across the 21-day interval increased, participants with more regular sleep schedules had slower overall response times on the Stroop. Higher acute stress exposures led to specific response time delays to neutral and self-relevant negative probes for those with high sleep/wake regularity. We found no impact of the number of acute stress events or stress intensities on working memory span, Stroop accuracy, or Trails response time.DiscussionThese data may indicate that sleep/wake regularity preserves adaptive inhibitory control responses to cumulative acute stress.
PROSPECT: A comprehensive sample acquisition and analysis package for lunar science and exploration
Authors: Trautner R. , Barber S. J. , Fisackerly R. , Heather D. , Houdou B. , Howe C. , Iacobellis S. , Leese M. , Mariani A. , Meogrossi G. , Murray N. , Panza C. , Reiss P. , Rusconi A. , Abernethy F. , Cann N. , Chinnery H. , Gscheidle C. , Landsberg P. , Lindner R. , Morse A. D. , Mortimer J. , Nicolae L. , Picchi P. , Sheridan S. , Verchovsky A. 
Published: April 2024

PROSPECT is a comprehensive payload package developed by the European Space Agency which will support the extraction and analysis of lunar surface and subsurface samples as well as the acquisition of data from additional environmental sensors. The key elements of PROSPECT are the ProSEED drill and the ProSPA analytical laboratory. ProSEED will support the acquisition of cryogenic samples from depths up to 1 m and deliver them to the ProSPA instrument. ProSPA will receive and seal samples in miniaturized ovens, heat them, physically and chemically process the released volatiles, and analyze the obtained constituents via mass spectrometry using two types of spectrometers. Contextual information will be provided by cameras which will generate multi-spectral images of the drill working area and of acquired samples, and via temperature sensors and a permittivity sensor that are integrated in the drill rod. The package is designed for minimizing volatile loss from the sample between acquisition and analysis. Initially developed for a flight on the Russian Luna-27 mission, the payload package design was adapted for a more generic lander accommodation and will be flown on a lunar polar lander mission developed within the NASA Commercial Lunar Payload Services (CLPS) program. PROSPECT targets science and exploration in lunar areas that might harbor deposits of volatiles, and also supports the demonstration of In-Situ Resource Utilization (ISRU) techniques in the lunar environment. PROSPECT operations are designed to be automated to a significant degree but rely on operator monitoring during critical phases. Here, we report the PROSPECT flight design that will be built, tested, and qualified according to European space technology engineering standards before delivery to the lander provider for spacecraft integration. The package is currently in the hardware manufacturing and integration phase with a target delivery to the NASA-selected CLPS lander provider in 2025.
Bir Modern Zamanlar Alimi Olarak Şeyh Google: İnternet, Geleneksel Ulema ve Kendi Kendine Öğrenme
Authors: Hamdeh Emad 
Published: April 2024

Geçtiğimiz asır boyunca kitaplar, medya ve internet vasıtasıyla bilgiyeerişimde eşine rastlanmamış bir artış gözlemlendi. Bu artış, İslamibilginin öğrenilmesi ve paylaşılmasında yeni yöntemlerin ortayaçıkmasına yol açtı. Bu makalede gittikçe artan sayıda sıradanMüslümanın basılı medya ve internet yoluyla dini tartışmalara dahilolmasının geleneksel İslami bilgiye ve pedagojik tekniklere nasılbir meydan okuma oluşturduğunu değerlendirdim. Ulemanın kendikendine öğrenmeyi yalnızca dinin doğru anlaşılmasına değil aynızamanda sahip oldukları otoritenin yeniden tanımlanmasına ve yenidenkeşfedilmesine yönelik de tehdit olarak gördüğünü açıkladım.Basılı ve dijital medyanın bir öğretmene ihtiyacı ortadan kaldırışını;kendi kendine öğrenmenin ve otorite olma iddiasında bulunmanınönünü açtığını gösterdim. Bireysel öğrenmeye getirdikleri eleştirilererağmen gelenekçiler, güncelliklerini koruyabilmek ve uzman olmayanlarlabaşa çıkabilmek adına interneti kabullendiler.
Yazı, sözden aşağıdır. Zira yazı, kendisine sorulan soruya hiçbir cevapveremeyen ve ancak canlı bir varlığa aldatıcı bir benzerlik gösterenresimler gibidir. Herhangi bir uyum yeteneği yoktur, her durumda aynıkelimeleri kullanır. Yazı, bilginin meşru bir çocuğu değildir; piçtir vebu piçe bir saldırıda bulunulduğunda ne ebeveynleri ne de bir başkasıonu savunur.
– Eflâtun
Classifications of the Names of Smolensk Streets
Authors: Smirnova Darya 
Published: April 2024

The article deals with two classifications of urbanonyms of the city of Smolensk in view of historical periods of the Russian state formation, and taking into account internal units included in the urbanonymic field.
In the ancient classification, the names of intracity objects are divided according to the principle of referring them to another significant object (as a rule, it was a church) or according to the principle of naming an object by the name of
a famous person, usually by the name of a saint.
In the modern classification, the principle has changed. Most of the renamed streets started to be called by the names of revolutionary figures, leaders of the Russian and world proletariat, by significant revolutionary events.
The classification of regional urbanonyms is important due to the fact that every onym is a cultural constant from the point of view of linguistics and reflects the peculiarities of the linguistic picture of the world of both an individual and society as a whole. For the streets of the city in the period from the 17th to the
beginning of the 20th century, renaming is not typical; after the revolution, the names were changed regularly.
The relation to another significant object (temple, monastery) was the most productive principle of nomination for the streets of ancient Smolensk. The main motive for the nomination of modern streets is their connection with people.
The Defender of the Orthodoxy or the Pious Catholic?
St. Sophia of Slutsk in the Narratives of 19th – early 20th Centuries
Authors: Koronevskii Viktor 
Published: April 2024

The paper is devoted to the history of the perception of St. Sophia of Slutsk by both Russian-language (Athanasius Vechorko, Gregory Kulzhinski, Feodor Sero-Solovievitch etc.) and Polish-language (Jozeph Krashevski, Josephine Osipovska, Vladislav Syrokomla, Teodor Korvin-Shimanovski) writers of the 19th – early 20th centuries. St. Sophia is canonized by the Orthodox Church. Despite
that, in the early 21st century Belarusian historians debated her denomination.
This article claims that the dispute related to the Saint’s denomination is based on two competing points of view which formed in the 19th century, although, at that time their proponents did not debate. Two traditions of perception of Sophia are distinguished. According to the first of these, Sophia was the defender of the Orthodoxy from the Catholics. Based on the second one, she was the Catholic of Roman or Greek rite who could hardly be related to the Orthodoxy. The link between the development of the Orthodox cult of Sophia at the turn of the 19th – 20th centuries and the elaboration of the concept «Slutsk – the stronghold of the persecuted Orthodoxy in the Polish-Lithuanian Commonwealth» is investigated.
Outcomes of Purse-string versus Conventional Linear Suture Closure of the Skin Wound following Ileostomy Reversal
Authors: Muhammad Adnan Khokhar  , Afaq Ahmad  , Ibad Ur Rehman  , Tashfeen Imtiaz  , Erum Najeeb  , Muhammad Burhan Ul Haq  , Roohi Saghir  
Published: April 2024

Background: Intestinal stomas are made in a variety of settings and their reversal is also a routine surgery. Due to their clean, contaminated nature, there is a high risk of surgical site infection post-operatively. The objective of this study is to determine the difference in outcomes in two different techniques of skin closure after stoma reversal
Methods: The study was conducted at department of general surgery, Pakistan Institute of Medical Sciences, Islamabad, over a period of six months. Seventy-one patients who underwent ileostomy reversal surgery in an elective setting were assigned two groups randomly: 34 in Group A and 37 in Group B. The group A patients underwent purse string closure for stoma site skin wound, whereas patients in group B underwent conventional linear closure. Time taken for surgery was noted and the patients were followed over one month period for development of any surgical site infection or dog-ear deformity.
Results: The incidence of surgical site infection was 8.8% in the purse string closure group compared to 43.2 % in the linear closure group. Seven patients in group B developed dog ear deformities, whereas no such case was noted in Group A.
Conclusions: Purse string closure is an effective and applicable technique for the closure of skin wounds after stoma reversal surgery. It is comparatively better in terms of prevention of surgical site infection as well as dog ear deformity in the closure of skin wounds after ileostomy reversal.
Gaya Komunikasi Akun Tiktok @msalbaniquotes dalam Menyampaikan Nilai-Nilai Islam di Kalangan Gen-Z
Authors: Wijaya Ardiansyah , Muktarruddin Muktarruddin 
Published: April 2024

<p class="Abstrak">Dalam perkembangan zaman, cara menyampaikan nilai-nilai Islam semakin modern dengan dukungan media baru. Media dakwah, seperti TikTok, efektif menyebarkan pesan Islam dengan kreatif dan relevan bagi Generasi Z seperti pada akun @msalbaniquotes. Penelitian ini menggunakan metode kualitatif yang bertujuan untuk mendeskripsikan dan menganalisis fenomena, peristiwa, aktivitas sosial, sikap, kepercayaan, persepsi, pemikiran orang secara individual maupun kelompok. Adapun tujuan penelitian ini, untuk mengetahui gaya komunikasi yang digunakan pada akun TikTok @msalbaniquotes. Dengan hasil penelitian menyatakan bahwa gaya komunikasi @msalbaniquotes terbukti menarik dan efektif, menghasilkan konten yang banyak disukai dan dibagikan di kalangan Gen-Z. Konten-konten tersebut tidak hanya menghibur, tetapi juga memotivasi dan membentuk sikap positif. Dari hasil penelitian, gaya komunikasi ini terbukti berhasil membangun pengaruh besar di kalangan Gen-Z, membuktikan bahwa media sosial bisa menjadi sarana efektif untuk menyebarkan pesan yang positif.</p>