bluuebunny/crossref_metadata_2025_split huggingface dataset:
3D Printable Polyelectrolyte Complex‐Integrated Interpenetrating Network Hydrogels with Customizable Mechanical Strength and pH‐Responsiveness
Authors: Pruthi Vaishali , Hirschberg Valerian , Théato Patrick 
Published: April 2024

AbstractHerein, a novel 3D printable ink designed for the fabrication of interpenetrating polymer network (IPN) hydrogels is introduced, ingeniously integrating a polyelectrolyte complex (PEC) of hyaluronic acid (HA) and chitosan (CS) with a photo‐crosslinkable P(OEGMA‐co‐EGDEMA) polymer. Initially, the carboxyl group of HA is modified with a photo‐labile ortho‐nitrobenzyl group, preventing premature PEC formation during 3D ink formulation. Subsequent UV illumination via digital light processing (DLP) simultaneously triggers the photo‐deprotection of the carboxyl group of HA and the photopolymerization of OEGMA crosslinked hydrogel, together creating a PEC‐integrated IPN hydrogel. Comprehensive characterizations, including NMR, IR, UV/Vis, TGA, DSC, SEM, and mechanical tests are conducted to evaluate the structural, morphological, and rheological properties of these hydrogels. Furthermore, adjustments to the composition of the 3D ink enable the production of hydrogels with a spectrum of mechanical strength and elastic modulus ranging from 1 to 10 kPa. The resultant PEC‐IPN hydrogels display excellent flexibility, compressive strength, high strain tolerance, pH responsiveness, and thermal stability. In essence, the approach seamlessly merges natural polyelectrolytes with technological innovation to refine 3D ink production. This method could mark a pivotal advancement in the realm of 3D materials, unlocking numerous prospective applications.
Multi‐Sensor Origami Platform: A Customizable System for Obtaining Spatiotemporally Precise Functional Readouts in 3D Models
Authors: Rahav Noam , Marrero Denise , Soffer Adi , Glickman Emma , Beldjilali‐Labro Megane , Yaffe Yakey , Tadmor Keshet , Leichtmann‐Bardoogo Yael , Ashery Uri , Maoz Ben M. 
Published: April 2024

AbstractBioprinting technology offers unprecedented opportunities to construct in vitro tissue models that recapitulate the 3D morphology and functionality of native tissue. Yet, it remains difficult to obtain adequate functional readouts from such models. In particular, it is challenging to position sensors in desired locations within pre‐fabricated 3D bioprinted structures. At the same time, bioprinting tissue directly onto a sensing device is not feasible due to interference with the printer head. As such, a multi‐sensing platform inspired by origami that overcomes these challenges by “folding” around a separately fabricated 3D tissue structure is proposed, allowing for the insertion of electrodes into precise locations, which are custom‐defined using computer‐aided‐design software. The multi‐sensing origami platform (MSOP) can be connected to a commercial multi‐electrode array (MEA) system for data‐acquisition and processing. To demonstrate the platform, how integrated 3D MEA electrodes can record neuronal electrical activity in a 3D model of a neurovascular unit is shown. The MSOP also enables a microvascular endothelial network to be cultured separately and integrated with the 3D tissue structure. Accordingly, how impedance‐based sensors in the platform can measure endothelial barrier function is shown. It is further demonstrated the device's versatility by using it to measure neuronal activity in brain organoids.
Multiome in the Same Cell Reveals the Impact of Osmotic Stress on Arabidopsis Root Tip Development at Single‐Cell Level
Authors: Liu Qing , Ma Wei , Chen Ruiying , Li Shang‐Tong , Wang Qifan , Wei Cai , Hong Yiguo , Sun Hai‐Xi , Cheng Qi , Zhao Jianjun , Kang Jingmin 
Published: April 2024

AbstractCell‐specific transcriptional regulatory networks (TRNs) play vital roles in plant development and response to environmental stresses. However, traditional single‐cell mono‐omics techniques are unable to directly capture the relationships and dynamics between different layers of molecular information within the same cells. While advanced algorithm facilitates merging scRNA‐seq and scATAC‐seq datasets, accurate data integration remains a challenge, particularly when investigating cell‐type‐specific TRNs. By examining gene expression and chromatin accessibility simultaneously in 16,670 Arabidopsis root tip nuclei, the TRNs are reconstructed that govern root tip development under osmotic stress. In contrast to commonly used computational integration at cell‐type level, 12,968 peak‐to‐gene linkage is captured at the bona fide single‐cell level and construct TRNs at an unprecedented resolution. Furthermore, the unprecedented datasets allow to more accurately reconstruct the coordinated changes of gene expression and chromatin states during cellular state transition. During root tip development, chromatin accessibility of initial cells precedes gene expression, suggesting that changes in chromatin accessibility may prime cells for subsequent differentiation steps. Pseudo‐time trajectory analysis reveal that osmotic stress can shift the functional differentiation of trichoblast. Candidate stress‐related gene‐linked cis‐regulatory elements (gl‐cCREs) as well as potential target genes are also identified, and uncovered large cellular heterogeneity under osmotic stress.
Edible Electronic Components Made from Recycled Food Waste
Authors: Radovanović Milan R. , Stojanović Goran M. , Simić Mitar , Suvara Dragana , Milić Lazar , Kojić Sanja , Škrbić Biljana D. 
Published: April 2024

AbstractA procedure is developed for producing basic electronic components utilizing materials sourced from discarded orange, grapefruit, lemon, apple, banana, potato, and carrot peels. Initially, these materials undergo dehydration, followed by a meticulous pulverization process to obtain fine powder. Natural adhesives like water, honey, sugar, starch, and gelatin are employed to interconnect the materials. Formed substrates are characterized using Scanning Electron Microscopy, Energy Dispersive X‐ray Spectroscopy, and an optical profilometer. Furthermore, the relative permittivity of the materials is determined. Three distinct types of substrates, derived from the aforementioned peels, are crafted in varying dimensions. Substrates measuring 4 cm × 2.5 cm host interdigital capacitive sensors, whereas larger 6 cm × 3.5 cm substrates accommodate inductor‐capacitor (LC) sensors. Each of the six samples undergoes individual dry testing, while LC sensors are additionally tested with the post‐application of artificial saliva and mouthwash liquids. The sensor's characterization involves measurement of impedance and phase angle for all samples. Capacitance is additionally measured for capacitors, and inductance for LC circuits. These assessments are carried out within the frequency range spanning from 1 MHz to 400 MHz. The objective is the development of fully functional electronic components, derived from discarded edible items, fostering sustainable practices, and finding applications in biomedicine.
Advancing Energy‐Storage Performance in Freestanding Ferroelectric Thin Films: Insights from Phase‐Field Simulations
Authors: Guo Changqing , Yang Huayu , Dong Shouzhe , Tang Shiyu , Wang Jing , Wang Xueyun , Huang Houbing 
Published: April 2024

AbstractAdvances in flexible electronics are driving the development of ferroelectric thin‐film capacitors toward flexibility and high energy storage performance. In the present work, the synergistic combination of mechanical bending and defect dipole engineering is demonstrated to significantly enhance the energy storage performance of freestanding ferroelectric thin films, achieved through the generation of a narrower and right‐shifted polarization‐electric field hysteresis loop. The recoverable energy storage density of freestanding PbZr0.52Ti0.48O3 thin films increases from 99.7 J cm−3 in the strain (defect) ‐free state to 349.6 J cm−3, marking a significant increase of 251%. The collective impact of the flexoelectric field, bending tensile strain, and defect dipoles contributes to this enhancement. The demonstrated synergistic optimization strategy has potential applicability to flexible ferroelectric thin film systems. Moreover, the energy storage properties of flexible ferroelectric thin films can be further fine‐tuned by adjusting bending angles and defect dipole concentrations, offering a versatile platform for control and performance optimization.
The Dual Use of SAM Molecules for Efficient and Stable Perovskite Solar Cells
Authors: Suo Jiajia , Yang Bowen , Bogachuk Dmitry , Boschloo Gerrit , Hagfeldt Anders 
Published: April 2024

AbstractPerovskite solar cells (PSCs) hold significant promise as the next‐generation materials in photovoltaic markets, owing to their ability to achieve impressive power conversion efficiencies, streamlined fabrication processes, cost‐effective manufacturing, and numerous other advantages. The utilization of self‐assembled monolayer (SAM) molecules has proven to be a significant success in enhancing device efficiency and extending device stability. This review highlights the dual use of SAM molecules in the realm of PSCs, which can not only serve as charge transport materials but also act as interfacial modulators. These research endeavors encompass a wide range of applications for various SAM molecules in both n‐i‐p and p‐i‐n structured PSCs, providing a deep insight into the underlying mechanisms. Furthermore, this review proposes current research challenges for future investigations into SAM materials. This timely and thorough review seeks to provide direction and inspiration for current research efforts dedicated to the ongoing incorporation of SAMs in the field of perovskite photovoltaics.
Electrochemical Modeling of Fast Charging in Batteries
Authors: Duan Xudong , Hu Dayong , Chen Weiheng , Li Jiani , Wang Lubing , Sun Shuguo , Xu Jun 
Published: April 2024

AbstractThe acceleration of fast charging capabilities has emerged as a pivotal objective within the realms of the battery, electric vehicle, and energy storage sectors. However, the classical electrochemical models are not able to describe voltages of the cell (Ucell), anode (Ua), and cathode (Uc) at high C‐rates. Herein, Ucell, Ua, and Uc are experimentally obtained under various C‐rates (0.1–2C) and identified the charge transfer resistance of the cathode (RCT,c) as the primary rate‐limiting factor. Thus, the anode is established as a multi‐scale coupling model with Fick's law and phase separation model applied, to discuss their effect on Ua and Li‐ion concentration prediction. 2D reconstruction structures for the cathode is established with RCT,c effect considered. Finally, the Ua, Uc, and Ucell are successfully predicted at different C‐rates. Results propose an accurate and versatile electrochemical model and highlight the importance of considering limiting factors in electrochemical modeling for fast charging.
Nitrogen‐Doped Anodic Li Oxide Films as Robust Li Metal Anodes and Solid‐State Electrolytes
Authors: Fan Ye , Kim Donggun , Chen Yimin , Bi Daoguang , Han Qi , Cai Qiran , Hu Xin , Mateti Srikanth , Yu Baozhi , Chen Ying Ian 
Published: April 2024

AbstractThe performance of the lithium (Li) metal anode in rechargeable batteries has been hampered by the formation of unstable solid‐electrolyte interphase layers, which compromise cycle life and pose significant safety concerns. Herein, for the first time, the anodizing oxidation of pure Li in a liquid electrolyte is developed by using tetrahydrofuran with LiNO3. With this novel process, thickness‐controllable Li oxide films with in situ nitrogen doping during the anodizing process can be obtained. The resulting nitrogen‐doped Li oxide film (NLO) exhibits a uniform surface of the Li metal anode, effectively suppressing Li dendrite growth and simultaneously improving Li ionic conductivity. In addition, the Li metal full cells with Li/NLO anodes perform a long stable life of 1100 cycles at 5C. More importantly, this work demonstrates the great potential of NLO films as a solid‐state electrolyte in solid‐state Li metal batteries. The symmetric Li cells with NLO films perform excellent cycling stability for 300 h at 2 mA cm−2 current density and high Li+ ion conductivity of ≈3 ×10−4 S cm−1 at room temperature. This research not only provides a novel Li anodizing process and a stable Li metal anode but also opens up new possibilities for new solid‐state Li metal battery technologies.
Clinical case report of intractable paroxysmal sympathetic hyperactivity in TANGO2 deficiency disorder
Authors: Morrison Kaitlin , Koshiya Hitoshi , Safier Robert , Brown Amanda , May Carol , Vockley Jerry , Ghaloul‐Gonzalez Lina 
Published: April 2024

AbstractTANGO2 deficiency disorder (TDD) is a neurodegenerative disease characterized by a broad and variable spectrum of clinical manifestations, even among individuals sharing the same pathogenic variants. Here, we report a severely affected individual with TDD presenting with intractable paroxysmal sympathetic hyperactivity (PSH). While progressive brain atrophy has been observed in TDD, PSH has not been reported. Despite comprehensive workup for an acute trigger, no definite cause was identified, and pharmacological interventions were ineffective to treat PSH. Ultimately care was redirected to comfort measures. This article expands the clinical phenotype of patients with TDD, highlights the possibility of PSH in these patients, and the need for continued research for better treatments of TDD.
Further characterization of ARSK‐related mucopolysaccharidosis type 10
Authors: Uludağ Alkaya Dilek , Taner Hasan Emir , Yıldırım Timur , Akpınar Evren , Tüysüz Beyhan 
Published: April 2024

AbstractMucopolysaccharidosis type 10 is caused by biallelic variants in ARSK, which encodes for a lysosomal sulfatase. To date, seven patients with a mild phenotype resembling spondyloepiphyseal dysplasia or multiple epiphyseal dysplasia have been described. In this report, we present two novel ARSK variants and report clinical and radiological findings of three patients. The patients' initial complaints were hip or knee pain and a waddling gait. All patients showed normal intelligence, normal hearing and eye examinations, and none had organomegaly. While typical dysostosis multiplex findings were not observed, mild platyspondyly with anterior beaking of some vertebral bodies, irregular vertebral endplates, wide ribs, inferior tapering of the ilea with a poorly developed acetabulum, irregularity of the central part of the femoral head, delayed ossification of the carpals were noted. Remarkably, all patients showed metaphyseal striation of the long bones, a crucial diagnostic clue to identify ARSK‐related MPS type 10. Interestingly, vertebral involvement regressed during follow‐up. On the other hand, hip dysplasia progressed in all patients. In conclusion, this study provides valuable long‐term results on a recently discovered form of MPS.
Prognostic factors in mobility disability among elderly patients in the emergency department: A single‐center retrospective study
Authors: Nagatomi Akiyoshi , Wakatake Haruaki , Masui Yoshihiro , Fujitani Shigeki 
Published: April 2024

AbstractAimWe aimed to evaluate the clinical characteristics and outcomes of elderly critically ill patients and identify prognostic factors for mobility disability at discharge.MethodsThis single‐center, retrospective cohort study investigated the period from April 2020 to January 2021. Patients ≥75 years old transferred to our emergency department and admitted to the intensive care unit (ICU) or intermediate unit in our hospital were eligible. Demographics, clinical characteristics, nutritional indicators, and nutritional screening scores were collected from chart reviews and analyzed. The primary outcome was the prevalence of mobility disability, compared to that of no mobility disability.ResultsA total of 124 patients were included in this present study. Median age was 83.0 years (interquartile range [IQR], 79.8–87.0 years) and 48 patients (38.7%) were female. Fifty‐two patients (41.9%) could not walk independently at discharge (mobility disability group). The remaining 72 patients were in the no mobility disability group. Multiple logistic regression analyses revealed clinical frailty scale (CFS) score ≥5 (odds ratio [OR] = 6.63, 95% confidence interval [CI] = 2.51–17.52, p < 0.001), SOFA score ≥6 (OR = 6.11, 95% CI = 1.57–23.77, p = 0.009), and neurological disorder as the main cause on admission (OR = 4.48, 95% CI = 1.52–13.20, p = 0.006) were independent and significant prognostic factors for mobility disability at discharge.ConclusionAmong elderly patients admitted to the emergency department, CFS ≥5, SOFA ≥6, and neurological disorders were associated with mobility disability at hospital discharge.
Association between eGFR and neurological outcomes among patients with out‐of‐hospital cardiac arrest: A nationwide prospective study in Japan
Authors: Kandori Kenji , Okada Asami , Nakajima Satoshi , Matsuyama Tasuku , Kitamura Tetsuhisa , Narumiya Hiromichi , Iizuka Ryoji , Hitosugi Masahito , Okada Yohei 
Published: April 2024

AbstractAimWe aimed to investigate the association between estimated glomerular filtration rate and prognosis in out‐of‐hospital cardiac arrest patients and explore the heterogeneity of the association.MethodsPatients experiencing out‐of‐hospital cardiac arrest due to medical causes and registered in the JAAM‐OHCA Registry between June 2014 and December 2019 were stratified into shockable rhythm, pulseless electrical activity, and asystole groups according to the cardiac rhythm at the scene. The primary outcome was a 1‐month favorable neurological status. Adjusted odds ratios with 95% confidence intervals were calculated to investigate the association between estimated glomerular filtration rate and outcomes using a logistic model.ResultsOf the 19,443 patients included, 2769 had initial shockable rhythm at the scene, 5339 had pulseless electrical activity, and 11,335 had asystole. As the estimated glomerular filtration rate decreased, the adjusted odds ratio for a 1‐month favorable neurological status decreased among those with initial shockable rhythm (estimated glomerular filtration rate, adjusted odds ratio [95% CI]: 45–59 mL/min/1.73 m2, 0.61 [0.47–0.79]; 30–44 mL/min/1.73 m2, 0.45 [0.32–0.62]; 15–29 mL/min/1.73 m2, 0.35 [0.20–0.63]; and <15 mL/min/1.73 m2, 0.14 [0.07–0.27]). Estimated glomerular filtration rate was associated with neurological outcomes in patients aged <65 years with initial shockable rhythm but not in those aged >65 years or patients with initial pulseless electrical activity or asystole.ConclusionThe estimated glomerular filtration rate is associated with neurological prognosis in out‐of‐hospital cardiac arrest patients with initial shockable rhythm at the scene but not in those with initial non‐shockable rhythm.
Paraneoplastic Calmodulin Kinase‐Like Vesicle‐Associated Protein (CAMKV) Autoimmune Encephalitis
Authors: Gilligan Michael , Lesnick Connie E. , Guo Yong , Bradshaw Michael J. , Ladha Shafeeq S. , Nowak Mihaela , Shah Maulik P. , Wittenborn John R. , Basal Eati , Hinson Shannon , Yang Binxia , Dubey Divyanshu , Mills John R. , Pittock Sean J. , Zekeridou Anastasia , McKeon Andrew 
Published: April 2024

ObjectivesTo report an autoimmune paraneoplastic encephalitis characterized by immunoglobulin G (IgG) antibody targeting synaptic protein calmodulin kinase‐like vesicle‐associated (CAMKV).MethodsSerum and cerebrospinal fluid (CSF) samples harboring unclassified antibodies on murine brain‐based indirect immunofluorescence assay (IFA) were screened by human protein microarray. In 5 patients with identical cerebral IFA staining, CAMKV was identified as top‐ranking candidate antigen. Western blots, confocal microscopy, immune‐absorption, and mass spectrometry were performed to substantiate CAMKV specificity. Recombinant CAMKV‐specific assays (cell‐based [fixed and live] and Western blot) provided additional confirmation.ResultsOf 5 CAMKV‐IgG positive patients, 3 were women (median symptom‐onset age was 59 years; range, 53–74). Encephalitis‐onset was subacute (4) or acute (1) and manifested with: altered mental status (all), seizures (4), hyperkinetic movements (4), psychiatric features (3), memory loss (2), and insomnia (2). Paraclinical testing revealed CSF lymphocytic pleocytosis (all 4 tested), electrographic seizures (3 of 4 tested), and striking MRI abnormalities in all (mesial temporal lobe T2 hyperintensities [all patients], caudate head T2 hyperintensities [3], and cortical diffusion weighted hyperintensities [2]). None had post‐gadolinium enhancement. Cancers were uterine adenocarcinoma (3 patients: poorly differentiated or neuroendocrine‐differentiated in 2, both demonstrated CAMKV immunoreactivity), bladder urothelial carcinoma (1), and non‐Hodgkin lymphoma (1). Two patients developed encephalitis following immune checkpoint inhibitor cancer therapy (atezolizumab [1], pembrolizumab [1]). All treated patients (4) demonstrated an initial response to immunotherapy (corticosteroids [4], IVIG [2]), though 3 died from cancer.InterpretationCAMKV‐IgG is a biomarker of immunotherapy‐responsive paraneoplastic encephalitis with temporal and extratemporal features and uterine cancer as a prominent oncologic association. ANN NEUROL 2024;96:21–33
Electrophilic Hydrosilylation of Electron‐Rich Alkenes Derived from Enamines
Authors: Laglera‐Gándara Carlos J. , Jiménez‐Pérez Julián , Fernández‐de‐Córdova Francisco J. , Ríos Pablo , Conejero Salvador 
Published: April 2024

AbstractThe low‐electron count, air‐stable, platinum complexes [Pt(ItBu’)(ItBu)][BArF] (C1) (ItBu=1,3‐di‐tert‐butylimidazol‐2‐ylidene), [Pt(SiPh)3(ItBuiPr)2][BArF] (C2) (ItBuiPr=1‐tert‐butyl‐3‐iso‐propylimidazol‐2‐ylidene), [Pt(SiPh)3(ItBuMe)2][BArF] (C3), [Pt(GePh3)(ItBuiPr)2][BArF] (C4), [Pt(GePh)3(ItBuMe)2][BArF] (C5) and [Pt(GeEt)3(ItBuMe)2][BArF] (C6) (ItBuMe=1‐tert‐butyl‐3‐methylimidazol‐2‐ylidene) are efficient catalysts (particularly the germyl derivatives) in both the silylative dehydrocoupling and hydrosilylation of electron rich alkenes derived from enamines. The steric hindrance exerted by the NHC ligand plays an important role in the selectivity of the reaction. Thus, bulky ligands are selective towards the silylative dehydrocoupling process whereas less sterically hindered promote the selective hydrosilylation reaction. The latter is, in addition, regioselective towards the β‐carbon atom of both internal and terminal enamines, leading to β‐aminosilanes. Moreover, the syn stereochemistry of the amino and silyl groups implies an anti Si−H bond addition across the double bond. All these facts point to a mechanistic picture that, according to experimental and computational studies, involves a non‐classical hydrosilylation process through an outer‐sphere mechanism in which a formal nucleophilic addition of the enamine to the silicon atom of a platinum σ‐SiH complex is the key step. This is in sharp contrast with the classical Chalk–Harrod mechanism prevalent in platinum chemistry.