bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alleviating the burden of depression: a simulation study on the impact of mental health services
Authors: Wilhelm M. , Bauer S. , Feldhege J. , Wolf M. , Moessner M. 
Published: April 2024

AbstractAimsDepressive disorders are ranked as the single leading cause of disability worldwide. Despite immense efforts, there is no evidence of a global reduction in the disease burden in recent decades. The aim of the study was to determine the public health impact of the current service system (status quo), to quantify its effects on the depression-related disease burden and to identify the most promising strategies for improving healthcare for depression on the population level.MethodsA Markov model was developed to quantify the impact of current services for depression (including prevention, treatment and aftercare interventions) on the total disease burden and to investigate the potential of alternative scenarios (e.g., improved reach or improved treatment effectiveness). Parameter settings were derived from epidemiological information and treatment data from the literature. Based on the model parameters, 10,000,000 individual lives were simulated for each of the models, based on monthly transition rates between dichotomous health states (healthy vs. diseased). Outcome (depression-related disease burden) was operationalized as the proportion of months spent in depression.ResultsThe current healthcare system alleviates about 9.5% (95% confidence interval [CI]: 9.2%–9.7%) of the total disease burden related to depression. Chronic cases cause the majority (83.2%) of depression-related burden. From a public health perspective, improving the reach of services holds the largest potential: Maximum dissemination of prevention (26.9%; CI: 26.7%–27.1%) and treatment (26.5%; CI: 26.3%–26.7%) would result in significant improvements on the population level.ConclusionsThe results confirm an urgent need for action in healthcare for depression. Extending the reach of services is not only more promising but also probably more achievable than increasing their effectiveness. Currently, the system fails to address the prevention and treatment of chronic cases. The large proportion of the disease burden associated with chronic courses highlights the need for improved treatment policies and clinical strategies for this group (e.g., disease management and adaptive or personalized interventions). The model complements the existing literature by providing a new perspective on the depression-related disease burden and the complex interactions between healthcare services and the lifetime course.
Public Responses to Unilateral Policymaking
Authors: Goehring Benjamin , Lowande Kenneth 
Published: April 2024

AbstractPresidents possess vast authority over policies and outcomes. Recent studies suggest the public checks this unilateralism through expressive opinions and political participation. We reevaluate this accountability link with a preregistered panel survey that incorporates a number of design and conceptual improvements over existing experimental studies. Our findings reveal a more complex relationship between presidential actions and public opinion. We find no evidence that the public reacts negatively to unilateralism – and some evidence they react positively. Respondents, however, may punish an incumbent for failing to implement the proposed policy change. While such a result suggests that the public can hold presidents accountable, we close by discussing how a lack of information likely renders this check moot.
Economic Development Drives Massive Global Estuarine Loss in the Anthropocene
Authors: Jung Nathalie W. , Lee Guan‐hong , Dellapenna Timothy M. , Jung Yoonho , Jo Tae‐Chang , Chang Jongwi , Figueroa Steven M. 
Published: April 2024

AbstractEstuaries have great ecological and economic value and sustain both population and economic growth. Global‐scale analyses suggest that human activities drive estuarine area change but these projections neglect direct human‐estuary interactions and socio‐economic feedbacks. Here, we quantified area changes of 2,396 estuaries in response to recent human impacts (e.g., land reclamation, estuarine dam construction) and economic development between 1984 and 2019, and find that estuarine area shrank by 5,372 km2 whereas upland submergence created 5,015 km2 of estuarine area elsewhere. Approximately 44% (n = 1,046) of today's estuaries have been directly altered through land reclamation, estuarine dam construction, or a combination of both, and ∼250,000 acres (1,027 km2) of estuarine area have been directly converted to urban or agricultural fields. Nearly 90% (923 km2) of land reclamation occurred in Asia linked to recent advances in economic development during the middle‐income stage. Additional historical mapping and 5‐year interval analyses revealed that while human alterations were insignificant during the low‐income stages, estuaries were predominantly altered during their middle‐income stages, where estuarine degradation is a common consequence of economic growth. However, this trend stabilizes in high‐income countries with the adaption of conservation laws and policies. Together, our results indicate that large‐scale estuarine loss can be avoided by preserving estuaries in low‐ and mid‐income countries in the early stages of economic development.
Continental Hotspots Tracks From an Analysis of GOCE Gravity Gradients Data
Authors: Greff‐Lefftz Marianne , Panet Isabelle , Besse Jean 
Published: April 2024

AbstractThis study aims to detect residual thermal anomalies along the path of a hotspot beneath the continental lithosphere using gradiometry data. We calculate perturbations in gravity vectors and gradients by employing a simple thermal anomaly model. The results highlight that the horizontal components of Bouguer gravity gradients, sensitive to source structure and elongation, exhibit substantial magnitudes, exceeding current detection levels. To improve signals from sources of different sizes and orientations, we apply a filtering approach involving wavelet transforms and rotated local frames. We also assess the impact of lateral crustal variations on the gravity field by introducing random density anomalies and a seismic crustal model, testing the method's ability to distinguish between these anomalies and thermal sources. Using Gravity field and steady‐state Ocean Circulation Explorer satellite data, we generated scale‐orientation diagrams aiming to identify signals aligned with the direction of plate movement and with a spatial scale of a few hundred kilometers (scale of the plumes). Maps of filtered Bouguer gravity gradients aligned with hotspot trajectories are generated for all continental hot plumes, with the position and the age of the intraplate volcanism to support the interpretation. While we do not show a clear signal in regions that are too tectonically complex or with lateral variations in the crust or at the lithospheric boundary correlated with the hotspot trace, we found observed signals with expected sign and amplitude over Hoggar, Tibesti, Darfour and Cameroon tracks in Africa and over Iceland and Jan Mayen in Greenland. However, determining corresponding mass source depths remains a complex task.
Forward Modeling of 3‐D Ion Properties in Jupiter’s Magnetosphere Using Juno/JADE‐I Data
Authors: Wang Jian‐zhao , Bagenal Fran , Wilson Robert J. , Nerney Edward , Crary Frank , Dols Vincent , Ebert Rob W. , Valek Phil W. , Allegrini Frederic , Kim Thomas K. , Szalay Jamey R. 
Published: April 2024

AbstractThe Jovian Auroral Distributions Experiment Ion sensor (JADE‐I) on NASA’s Juno mission provides in‐situ measurements of ions from 0.1 to 46.2 keV/q inside Jupiter’s magnetosphere. JADE‐I is used to study the plasma with two types of datasets from the same measurement: Time‐of‐flight (TOF) and SPECIES. The TOF dataset provides mass‐per‐charge measurements with a range of 1–64 amu/q but oversamples particles over 6π steradian viewing per spacecraft spin and has little directional information. On the other hand, the SPECIES dataset can provide a good measurement of the flow direction but does not provide mass‐per‐charge information due to the telemetry limit. In this study, we developed a 2‐step forward modeling method that combines the advantages and avoids the disadvantages of TOF and SPECIES data to derive the 3‐D properties of heavy ions. Assuming that the ion velocity distribution can be described with the kappa distribution, we first perform the forward model fit of the TOF data to calculate the relative abundance of heavy ion species. Then we fix the relative abundance and perform the second forward model fit on the SPECIES data. Using this method, we obtain the densities of different heavy ions, the shared temperature and kappa value, and the 3‐D flow velocity vector. Some data examples of the equatorial plasma disk before Perijove 24 are included to demonstrate the method. Plasma properties can then be mapped to explore spatial and temporal variabilities in Jupiter’s magnetosphere.
Long‐Term Variability and Tendencies in Mesosphere and Lower Thermosphere Winds From Meteor Radar Observations Over Esrange (67.9°N, 21.1°E)
Authors: Ramesh K. , Mitchell Nicholas J. , Hindley Neil P. , Moffat‐Griffin Tracy 
Published: April 2024

AbstractLong‐term variabilities of monthly zonal (U) and meridional winds (V) in northern polar mesosphere and lower thermosphere (MLT, ∼80–100 km) are investigated using meteor radar observations during 1999–2022 over Esrange (67.9°N, 21.1°E). The summer (June‐August) mean zonal winds are characterized by westward flow up to ∼88–90 km and eastward flow above this height. The summer mean meridional winds are equatorward with strong jet at ∼85–90 km and it weakens above this height. The U and V exhibit strong interannual variability that varies with altitude and month or season. The responses of U and V anomalies (from 1999 to 2003) to solar cycle (SC), Quasi Biennial Oscillation at 10 and 30 hPa, El Niño‐Southern Oscillation, North Atlantic Oscillation, ozone (O3) and carbon dioxide (CO2) are analyzed using multiple linear regression. From analysis, significant regions of correlations between MLT winds and above potential drivers vary with altitude and month. The positive responses of U and V to SC (up to 15 m/s/100 sfu) indicates the strengthening of eastward winds in mid‐late winter, and poleward winds in late autumn and early winter. The O3 likely intensifies the eastward and poleward winds (∼100 m/s/ppmv) in winter and early spring. The CO2 significantly influence the eastward flow in late winter and summer (above ∼90–95 km) and strengthen the meridional circulation. The significant positive trend in U peaks in summer, late autumn and early winter (∼0.6 m/s/year), the negative trend in V is more prominent in summer above ∼90–95 km.
The lincRNA JUNI regulates the stress-dependent induction of c-Jun, cellular migration and survival through the modulation of the DUSP14-JNK axis
Authors: Kumar Vikash , Sabaté-Cadenas Xavier , Soni Isha , Stern Esther , Vias Carine , Ginsberg Doron , Romá-Mateo Carlos , Pulido Rafael , Dodel Martin , Mardakheh Faraz K. , Shkumatava Alena , Shaulian Eitan 
Published: April 2024

AbstractCancer cells employ adaptive mechanisms to survive various stressors, including genotoxic drugs. Understanding the factors promoting survival is crucial for developing effective treatments. In this study, we unveil a previously unexplored long non-coding RNA, JUNI (JUN-DT, LINC01135), which is upregulated by genotoxic drugs through the activation of stress-activated MAPKs, JNK, and p38 and consequently exerts positive control over the expression of its adjacent gene product c-Jun, a well-known oncoprotein, which transduces signals to multiple transcriptional outputs. JUNI regulates cellular migration and has a crucial role in conferring cellular resistance to chemotherapeutic drugs or UV radiation. Depletion of JUNI markedly increases the sensitivity of cultured cells and spheroids to chemotherapeutic agents. We identified 57 proteins interacting with JUNI. The activity of one of them the MAPK phosphatase and inhibitor, DUSP14, is counteracted by JUNI, thereby, facilitating efficient JNK phosphorylation and c-Jun induction when cells are exposed to UV radiation. The antagonistic interplay with DUSP14 contributes not only to c-Jun induction but also augments the survival of UV-exposed cells. In summary, we introduce JUNI as a novel stress-inducible regulator of c-Jun, positioning it as a potential target for enhancing the sensitivity of cancer cells to chemotherapy.
Emerging racial disparities among Medicare beneficiaries and Veterans with metastatic castration-sensitive prostate cancer
Authors: George Daniel J. , Agarwal Neeraj , Ramaswamy Krishnan , Klaassen Zachary , Bitting Rhonda L. , Russell David , Sandin Rickard , Emir Birol , Yang Hongbo , Song Wei , Lin Yilu , Hong Agnes , Gao Wei , Freedland Stephen J. 
Published: April 2024

Abstract
Background
Previous studies have shown that Black men receive worse prostate cancer care than White men. This has not been explored in metastatic castration-sensitive prostate cancer (mCSPC) in the current treatment era.

Methods
We evaluated treatment intensification (TI) and overall survival (OS) in Medicare (2015–2018) and Veterans Health Administration (VHA; 2015–2019) patients with mCSPC, classifying first-line mCSPC treatment as androgen deprivation therapy (ADT) + novel hormonal therapy; ADT + docetaxel; ADT + first-generation nonsteroidal antiandrogen; or ADT alone.

Results
We analyzed 2226 Black and 16,071 White Medicare, and 1020 Black and 2364 White VHA patients. TI was significantly lower for Black vs White Medicare patients overall (adjusted odds ratio [OR] 0.68; 95% confidence interval [CI] 0.58–0.81) and without Medicaid (adjusted OR 0.70; 95% CI 0.57–0.87). Medicaid patients had less TI irrespective of race. OS was worse for Black vs White Medicare patients overall (adjusted hazard ratio [HR] 1.20; 95% CI 1.09–1.31) and without Medicaid (adjusted HR 1.13; 95% CI 1.01–1.27). OS was worse in Medicaid vs without Medicaid, with no significant OS difference between races. TI was significantly lower for Black vs White VHA patients (adjusted OR 0.75; 95% CI 0.61–0.92), with no significant OS difference between races.

Conclusions
Guideline-recommended TI was low for all patients with mCSPC, with less TI in Black patients in both Medicare and the VHA. Black race was associated with worse OS in Medicare but not the VHA. Medicaid patients had less TI and worse OS than those without Medicaid, suggesting poverty and race are associated with care and outcomes.
A therapist-administered self-report version of the Walking Index for Spinal Cord Injury II (WISCI): a psychometric study
Authors: Ben Marsha , Tamburella Federica , Lorusso Matteo , Glinsky Joanne V. , Tranter Keira E. , Scivoletto Giorgio , Blecher Lynn , Harris Anneliese , Galeoto Giovanni , Wan Joshua , Harvey Lisa A. 
Published: April 2024

Abstract
Objective
To develop a self-report version of the Walking Index for Spinal Cord Injury II (WISCI II) and to test its reliability and validity.

Study design
Psychometric study.

Setting
Spinal cord injury (SCI) rehabilitation centres in Australia and Italy.

Participants
Eighty people with SCI were recruited from a sample of convenience.

Methods
Two self-report versions of the WISCI II were developed. Both versions were administered in English at the Australian site, and in Italian at the Italian site through an online platform. The format of the first self-report version (SR-V1) was similar to the original face-to-face WISCI II. The second self-report version (SR-V2) had more questions, but each question required participants to focus on one aspect of walking at a time. Participants completed SR-V1 and SR-V2 with assistance from research physiotherapists on two separate occasions, three to seven days apart. The original WISCI II was then administered through a face-to-face assessment by an independent physiotherapist. The intra-rater reliability and validity of SR-V1 and SR-V2 were determined with intraclass correlation coefficients (ICC) and percent close agreements.

Results
The data from the Australian and Italian sites were pooled. The validity and reliability of the two self-report versions were very similar, with SR-V2 performing slightly better than SR-V1. The ICC (95% confidence interval) of SR-V2 was 0.87 (0.81–0.92). The ICC reflecting the agreement between the self-report and the face-to-face WISCI was 0.89 (0.84–0.93).

Conclusion
Both versions of the self-report WISCI II provide a reasonable substitute for a face-to-face assessment although therapists preferred SR-V2.
Chemokine-derived oncolytic peptide induces immunogenic cancer cell death and significantly suppresses tumor growth
Authors: Furukawa Natsuki , Yang Wendy , Chao Alex R. , Patil Akash , Mirando Adam C. , Pandey Niranjan B. , Popel Aleksander S. 
Published: April 2024

AbstractChemokinostatin-1 (CKS1) is a 24-mer peptide originally discovered as an anti-angiogenic peptide derived from the CXCL1 chemokine. Here, we demonstrate that CKS1 acts not only as an anti-angiogenic peptide but also as an oncolytic peptide due to its structural and physical properties. CKS1 induced both necrotic and apoptotic cell death specifically in cancer cells while showing minimal toxicity in non-cancerous cells. Mechanistically, CKS1 disrupted the cell membrane of cancer cells quickly after treatment and activated the apoptotic pathway at later time points. Furthermore, immunogenic molecules were released from CKS1-treated cells, indicating that CKS1 induces immunogenic cell death. CKS1 effectively suppressed tumor growth in vivo. Collectively, these data demonstrate that CKS1 functions as an oncolytic peptide and has a therapeutic potential to treat cancer.
Dupilumab-associated head and neck dermatitis shows a pronounced type 22 immune signature mediated by oligoclonally expanded T cells
Authors: Bangert Christine , Alkon Natalia , Chennareddy Sumanth , Arnoldner Tamara , Levine Jasmine P. , Pilz Magdalena , Medjimorec Marco A. , Ruggiero John , Cohenour Emry R. , Jonak Constanze , Damsky William , Griss Johannes , Brunner Patrick M. 
Published: April 2024

AbstractDupilumab, an IL4R-blocking antibody, has shown clinical efficacy for atopic dermatitis (AD) treatment. In addition to conjunctivitis/blepharitis, the de novo appearance of head/neck dermatitis is now recognized as a distinct side effect, occurring in up to 10% of patients. Histopathological features distinct from AD suggest a drug effect, but exact underlying mechanisms remain unknown. We profiled punch biopsies from dupilumab-associated head and neck dermatitis (DAHND) by using single-cell RNA sequencing and compared data with untreated AD and healthy control skin. We show that dupilumab treatment was accompanied by normalization of IL-4/IL-13 downstream activity markers such as CCL13, CCL17, CCL18 and CCL26. By contrast, we found strong increases in type 22-associated markers (IL22, AHR) especially in oligoclonally expanded T cells, accompanied by enhanced keratinocyte activation and IL-22 receptor upregulation. Taken together, we demonstrate that dupilumab effectively dampens conventional type 2 inflammation in DAHND lesions, with concomitant hyperactivation of IL22-associated responses.
Maternal hybrid immunity and risk of infant COVID-19 hospitalizations: national case-control study in Israel
Authors: Guedalia Joshua , Lipschuetz Michal , Cahen-Peretz Adva , Cohen Sarah M. , Sompolinsky Yishai , Shefer Galit , Melul Eli , Ergaz-Shaltiel Zivanit , Goldman-Wohl Debra , Yagel Simcha , Calderon-Margalit Ronit , Beharier Ofer 
Published: April 2024

AbstractHybrid immunity, acquired through vaccination followed or preceded by a COVID-19 infection, elicits robust antibody augmentation. We hypothesize that maternal hybrid immunity will provide greater infant protection than other forms of COVID-19 immunity in the first 6 months of life. We conducted a case-control study in Israel, enrolling 661 infants up to 6 months of age, hospitalized with COVID-19 (cases) and 59,460 age-matched non-hospitalized infants (controls) between August 24, 2021, and March 15, 2022. Infants were grouped by maternal immunity status at delivery: Naïve (never vaccinated or tested positive, reference group), Hybrid-immunity (vaccinated and tested positive), Natural-immunity (tested positive before or during the study period), Full-vaccination (two-shot regimen plus 1 booster), and Partial-vaccination (less than full three shot regimen). Applying Cox proportional hazards models to estimate the hazard ratios, which was then converted to percent vaccine effectiveness, and using the Naïve group as the reference, maternal hybrid-immunity provided the highest protection (84% [95% CI 75-90]), followed by full-vaccination (66% [95% CI 56-74]), natural-immunity (56% [95% CI 39-68]), and partial-vaccination (29% [95% CI 15-41]). Maternal hybrid-immunity was associated with a reduced risk of infant hospitalization for Covid-19, as compared to natural-immunity, regardless of exposure timing or sequence. These findings emphasize the benefits of vaccinating previously infected individuals during pregnancy to reduce COVID-19 hospitalizations in early infancy.
Northeast Pacific warm blobs sustained via extratropical atmospheric teleconnections
Authors: Shi Jian , Huang Hao , Fedorov Alexey V. , Holbrook Neil J. , Zhang Yu , Ding Ruiqiang , Luo Yongyue , Wang Shengpeng , Chen Jiajie , Hu Xi , Liu Qinyu , Huang Fei , Lin Xiaopei 
Published: April 2024

AbstractLarge-scale marine heatwaves in the Northeast Pacific (NEP), identified here and previously as ‘warm blobs’, have devastating impacts on regional ecosystems. An anomalous atmospheric ridge over the NEP is known to be crucial for maintaining these warm blobs, also causing abnormally cold temperatures over North America during the cold season. Previous studies linked this ridge to teleconnections from tropical sea surface temperature anomalies. However, it was unclear whether teleconnections from the extratropics could also contribute to the ridge. Here we show that planetary wave trains, triggered by increased rainfall and latent heat release over the Mediterranean Sea accompanied by decreased rainfall over the North Atlantic, can transport wave energy to the NEP, guided by the westerly jet, and induce a quasi-barotropic ridge there. Our findings provide insights into extratropical teleconnections sustaining the NEP ridge, offering a source of potential predictability for the warm blobs and temperature fluctuations over North America.
Biomimetic NIR-II fluorescent proteins created from chemogenic protein-seeking dyes for multicolor deep-tissue bioimaging
Authors: Xu Jiajun , Zhu Ningning , Du Yijing , Han Tianyang , Zheng Xue , Li Jia , Zhu Shoujun 
Published: April 2024

AbstractNear-infrared-I/II fluorescent proteins (NIR-I/II FPs) are crucial for in vivo imaging, yet the current NIR-I/II FPs face challenges including scarcity, the requirement for chromophore maturation, and limited emission wavelengths (typically < 800 nm). Here, we utilize synthetic protein-seeking NIR-II dyes as chromophores, which covalently bind to tag proteins (e.g., human serum albumin, HSA) through a site-specific nucleophilic substitution reaction, thereby creating proof-of-concept biomimetic NIR-II FPs. This chemogenic protein-seeking strategy can be accomplished under gentle physiological conditions without catalysis. Proteomics analysis identifies specific binding site (Cys 477 on DIII). NIR-II FPs significantly enhance chromophore brightness and photostability, while improving biocompatibility, allowing for high-performance NIR-II lymphography and angiography. This strategy is universal and applicable in creating a wide range of spectrally separated NIR-I/II FPs for real-time visualization of multiple biological events. Overall, this straightforward biomimetic approach holds the potential to transform fluorescent protein-based bioimaging and enables in-situ albumin targeting to create NIR-I/II FPs for deep-tissue imaging in live organisms.