bluuebunny/crossref_metadata_2025_split huggingface dataset:
School‐Based Mental Health Clinics
Authors: Costello‐Wells Brenda , McFarland Ladrienne , Reed Joan , Walton Kim 
Published: August 2007

TOPIC The research, planning, implementation, and evaluation of school‐based mental health clinics located throughout a large metropolitan city, which were established in a joint project by four local mental health centers.PURPOSE To explain the evolution of the idea of providing school‐based mental health to a large, inner‐city population, including the delineation of team roles and responsibilities.SOURCES Nursing, medical, social work, and educational literature. Notes detailing the formation of InteCare, the school‐based mental health clinic system.CONCLUSIONS Providing mental health services in inner‐city schools improves access and removes barriers to treatment for this population. Working collegially with school personnel and families significantly improves the academic function of the children, the functioning of the families, and the relationships between parents and schools.
Impact of War on American Adolescents: The views expressed in this article are those of the authors and do not reflect the official position of the Department of the Navy, the Department of Defense, or the U.S. government.
Authors: Hardin Sally Brosz , Hayes Eileen , Cheever Kerry H. , Addy Cheryl 
Published: August 2007

PROBLEM The impact of the Persian Gulf war on adolescents in Columbia, Charleston, and Sumter, SC.METHODS Four semiannual surveys measured adolescents' exposure to and evaluations of the Persian Gulf war, and the relationship between this exposure and mental distress.FINDINGS Of the sample, 814 (65.9%) reported being distressed by the war and 849 (69%) reported feeling better after the war ended. More than half the sample had a friend or relative sent to the war (n = 725, 58.8%), and of these, 458 were African American. Nine percent (n = 111) of the sample had a mother, father, or both a mother and a father in the war.CONCLUSIONS There was a positive correlation between adolescents' ratings on the Negative Impact of War Scores and Mental Distress Scores despite the easy victory and public support for the war in the United States. Females and African Americans viewed the war more negatively than did Caucasian males.
Geography and Textual Allusions: Interpreting Isaiah xl-lv and Lamentations as Judahite Texts
Authors: Tiemeyer Lena-Sofia 
Published: August 2007

AbstractThis article proposes a new interpretation of the allusions to Lamentations as found in Isa. xl-lv. Scholars generally assume that the author of Isa. xl-lv transforms the Judahite material in Lamentations to fit his alleged exilic audience. Given the possible Judahite setting of Isa. xl-lv, however, there is need of reassessment. We shall here investigate the extent to which the bias toward an exilic setting of Isa. xl-lv has influenced the interpretation of the passages in which the allusions occur, and then explore how a Judahite setting of Isa. xl-lv alters this interpretation. As a result, we shall see that a Judahite setting of both texts not only facilitates but also enhances the interpretation of the same textual allusions.
Israelite, Moabite and Sabaean War-h&#803&#275rem Traditions and the Forging of National Identity: Reconsidering the Sabaean Text RES 3945 in Light of Biblical and Moabite Evidence
Authors: Monroe Lauren A.S. 
Published: August 2007

AbstractIn the biblical conquest accounts,hērem signifies ritual destruction and consecration to the deity of entire enemy populations and towns. The root hrm also appears in two extrabiblical conquest accounts: the Mesha Inscription and the Sabaean text, RES 3945. This article revisits the interpretation of the Sabaean text in light of recent scholarship in South Arabian Studies, and argues that RES 3945 should be placed on equal footing with the Mesha Inscription for its relevance for understanding the biblical hērem. Taken together, these sources situate the war-hērem in the context of early state formation, and suggest that the tripartite relationship between people, land and god, expressed in terms of b&ebrever&icaront, or &#147covenant,&#148 in ancient Israel, may in fact have found expression more widely, in a tribal, inland Palestinian setting with cultural connections extending into the South Arabian Peninsula.
The Place of the Name in Deuteronomy
Authors: Richter Sandra L. 
Published: August 2007

AbstractThe location of Deuteronomy's central sanctuary is an old and important question. This article revisits the question via the lens of the oft' repeated deuteronomic phrase, l&#0277&#353akk&#275n &#353&#0277m&#244 &#353&#257m. Recent research indicates that this phrase is a loan-adaptation of Akkadian &#353uma &#353ak&#257nu, an idiom formulaic to the typology of the Mesopotamian royal monumental tradition, and associated with the inscription and installation of display monuments. Consequently, the frequent description of Deuteronomy's central sanctuary as hamm&#257q&#244m ,&#259&#353er yibh&#803ar YHWH ,&#0277l&#333h&#234k&#257 l&#0277&#353akk&#275n &#353&#0277mo &#353&#257m indicates that this place was associated in some manner with an inscribed monument. A survey of the theme of inscribed monuments throughout the Book of Deuteronomy confi rms this proposition, and points to the deuteronomic identity of &#147the place&#148 as Mount Ebal. Although scholarship has tended to discount the significance of the Ebal tradition to the larger message of the Book of Deuteronomy, the literary, archaeological, epigraphic, and geographical data reviewed here confirm the probability of Ebal as Israel's first central sanctuary, and the installation of Yahweh's monument there as the climax of a critical theme within the book.
Activity of TKI258 against primary cells and cell lines with FGFR1 fusion genes associated with the 8p11 myeloproliferative syndrome
Authors: Chase Andrew , Grand Francis H. , Cross Nicholas C. P. 
Published: August 2007

Abstract
The 8p11 myeloproliferative syndrome (EMS) is an aggressive, atypical stem cell myeloproliferative disorder associated with chromosome translocations that disrupt and constitutively activate FGFR1 by fusion to diverse partner genes. To explore the possibility of targeted therapy for EMS, we have investigated the use of TKI258, a multitargeted receptor tyrosine kinase inhibitor with activity against FGFR, VEGFR, PDGFR, FLT3, and KIT that is currently being assessed for the treatment of a variety of malignancies in phase 1 clinical studies. The viability of Ba/F3 cells transformed to IL3 independence by ZNF198-FGFR1 or BCR-FGFR1 was specifically inhibited by TKI258 with IC50 values of 150 nM and 90 nM, respectively. Inhibition was accompanied by dose-dependent inhibition of phosphorylation of each fusion gene, ERK, and STAT5. TKI258 also specifically inhibited proliferation and survival of the FGFR1OP2-FGFR1–positive KG1 and KG1A cell lines, resulting in increased levels of apoptosis. Primary cells from EMS patients showed significant, dose-dependent responses in liquid culture and in methylcellulose colony assays compared with controls. This work provides evidence that targeted therapy may be beneficial for patients with EMS.
Facile Derivatization of Pyridyloxazole-type Fluorophore via Click Chemistry
Authors: Shi Jing , Liu Lei , He Jing , Meng Xiangming , Guo Qingxiang 
Published: August 2007

Abstract
New derivatives of the pyridyloxazole-type fluorophore were synthesized in high efficiency through click chemistry. This method is potentially useful for the combinatory screening of fluorescent labels to target specific biological processes. Using this method, we successfully developed three new ratiometric dual-fluorescent pH sensors.
Phosphine-free Fabrication of CdSe Quantum Dots with Good Thermal Stability and Promising Application in Multiplexed Bioassay
Authors: Xing Bin , Li Wan-wan , Dou Hong-jing , Zhang Peng-fei , Sun Kang 
Published: August 2007

Abstract
High-quality cadmium selenide (CdSe) quantum dots (QDs) with good thermal stability were prepared by using liquid paraffin as a solvent and oleic acid as a ligand under relative low temperatures. Moreover, the as-prepared CdSe quantum dots were embedded into the porous polystyrene (PS) beads to fabricate optically encoded beads, which suggests their promising application in multiplexed bioassays.
A Novel One-pot Synthesis of Pyrroloquinoline and Pyrroloisoquinoline Derivatives in Ionic Liquid
Authors: Ma Chen , Ren Yan , Zhang Qun , Ding Kai , Zhao Jun , Zhang Dongju 
Published: August 2007

Abstract
A Sonogashira coupling–1,3-dipolar cycloaddition sequence of a (hetero)arenecarbonyl chloride 1, a terminal alkyne 2, and a suitable quinolinium bromide 3 or isoquinolinium bromide 4 was carried out in ionic liquid on the basis of a consecutive one-pot three-component process. Optimization of ionic liquid and recycling of the catalyst were discussed.
Bone Regeneration Is Regulated by Wnt Signaling
Authors: Kim Jae-Beom , Leucht Philipp , Lam Kentson , Luppen Cynthia , Ten Berge Derk , Nusse Roel , Helms Jill A 
Published: August 2007

Abstract
Tissue regeneration is increasingly viewed as reactivation of a developmental process that, when misappropriated, can lead to malignant growth. Therefore, understanding the molecular and cellular pathways that govern tissue regeneration provides a glimpse into normal development as well as insights into pathological conditions such as cancer. Herein, we studied the role of Wnt signaling in skeletal tissue regeneration.
Introduction: Some adult tissues have the ability to regenerate, and among these, bone is one of the most remarkable. Bone exhibits a persistent, lifelong capacity to reform after injury, and continual bone regeneration is a prerequisite to maintaining bone mass and density. Even slight perturbations in bone regeneration can have profound consequences, as exemplified by conditions such as osteoporosis and delayed skeletal repair. Here, our goal was to determine the role of Wnts in adult bone regeneration.
Materials and Methods: Using TOPgal reporter mice, we found that damage to the skeleton instigated Wnt reporter activity, specifically at the site of injury. We used a skeletal injury model to show that Wnt inhibition, achieved through adenoviral expression of Dkk1 in the adult skeleton, prevented the differentiation of osteoprogenitor cells.
Results: As a result, injury-induced bone regeneration was reduced by 84% compared with controls. Constitutive activation of the Wnt pathway resulting from a mutation in the Lrp5 Wnt co-receptor results in high bone mass, but our experiments showed that this same point mutation caused a delay in bone regeneration. In these transgenic mice, osteoprogenitor cells in the injury site were maintained in a proliferative state and differentiation into osteoblasts was delayed.
Conclusions: When considered together, these data provide a framework for understanding the roles of Wnt signaling in adult bone regeneration and suggest a feasible approach to treating clinical conditions where enhanced bone formation is desired.
Control of the SOST Bone Enhancer by PTH Using MEF2 Transcription Factors
Authors: Leupin Olivier , Kramer Ina , Collette Nicole M , Loots Gabriela G , Natt François , Kneissel Michaela , Keller Hansjoerg 
Published: August 2007

Abstract
Expression of the osteocyte-derived bone formation inhibitor sclerostin in adult bone requires a distant enhancer. We show that MEF2 transcription factors control this enhancer and mediate inhibition of sclerostin expression by PTH.
Introduction: Sclerostin encoded by the SOST gene is a key regulator of bone formation. Lack of SOST expression is the cause for the progressive bone overgrowth disorders sclerosteosis and Van Buchem disease. We have previously identified a distant enhancer within the 52-kb Van Buchem disease deletion downstream of the SOST gene that is essential for its expression in adult bone. Furthermore, we and others have reported that SOST expression is suppressed by PTH. The aim of this study was to identify transcription factors involved in SOST bone enhancer activity and mediating PTH responsiveness.
Materials and Methods: Regulation of the SOST enhancer and promoter was studied by luciferase reporter gene assays. Transcription factor binding sites were mapped by footprint analysis and functional mutation analyses using transient transfections of osteoblast-like UMR-106 cells that exhibit endogenous SOST expression. Specific transcription factor binding was predicted by sequence analysis and shown by gel retardation assays and antibody-induced supershifts. Expression of myocyte enhancer factors 2 (MEF2) was detected by in situ hybridization, quantitative RT-PCR (qPCR), and immunohistochemistry. The role of MEF2s in SOST expression was assessed by reporter gene assays and siRNA-mediated RNA knockdown.
Results: PTH completely suppressed the transcriptional activity of the SOST bone enhancer but did not affect the SOST promoter. A MEF2 response element was identified in the bone enhancer. It was essential for transcriptional activation, bound MEF2 transcription factors, and mediated PTH responsiveness. Expression of MEF2s in bone was shown by qPCR, in situ hybridization, and immunohistochemistry. MEF2s and sclerostin co-localized in osteocytes. Enhancer activity was stimulated by MEF2C overexpression and inhibited by co-expression of a dominant negative MEF2C mutant. Finally, siRNA-mediated knockdown of MEF2A, C, and D suppressed endogenous SOST expression in UMR-106 osteoblast-like cells.
Conclusions: These data strongly suggest that SOST expression in osteocytes of adult bone and its inhibition by PTH is mediated by MEF2A, C, and D transcription factors controlling the SOST bone enhancer. Hence, MEF2s are implicated in the regulation of adult bone mass.
Eine publizistische Debatte als Geburtsstunde des „Marburger Programms“
Authors: Schmidt-Recla Adrian , Steinberg Holger 
Published: August 2007

Abstract

I. Einleitung

Das „Marburger Programm“ von Liszts (1851–1919) markiert in der heutigen Wahrnehmung den Aufbruch in die kriminalpolitische Moderne. Zwar ist bekannt, dass relative, präventionistische Theorien in der Strafrechtswissenschaft auch schon vor von Liszt vertreten wurden. Die Untersuchungen, die zur Veröffentlichung des jungen von Liszt bislang angestellt worden sind, haben freilich den unmittelbaren Anlass und publizistischen Kontext des Aufsatzes noch nicht genügend ausgeleuchtet: Das Marburger Programm war keine singuläre Veröffentlichung, sondern eingebettet in eine zwischen Juristen, Strafvollzugsbeamten und Psychiatern in den Jahren 1879–1882 cum ira et studio geführte Debatte, deren genauere Überprüfung bislang unbeachtete Einsichten zu Tage fördert.
Täterschaft und Teilnahme im Statut des IStGH und Anpassungsbedarf der italienischen Regelung
Authors: Martino Alberto di 
Published: August 2007

Abstract

I. Anpassung der italienischen Vorschriften über Teilnahme an das „Römische Statut“

Im Zentrum dieses Beitrags steht die Frage, wie sich die Vorschriften über die Teilnahme mehrerer an einer Straftat im Römischen Statut des Internationalen Gerichtshofs (im Folgenden: „Statut“ und „IStGH“ abgekürzt) zu der wesentlich anders gefassten Regelung im italienischen Recht verhalten.
Der Europäische Haftbefehl und die polnische Verfassung – jüngste Entwicklungen
Authors: Weigend Ewa , Sakowicz Andrzej 
Published: August 2007

Abstract

1. Einführung

In Polen wurde die Verfassung geändert, um die Auslieferung eigener Staatsangehöriger aufgrund eines Europäischen Haftbefehls (EuHB) möglich zu machen. Diese Verfassungsänderung war nötig geworden, da der polnische Verfassungsgerichtshof im Jahr 2005 die Auslieferung polnischer Staatsangehöriger auf der Grundlage des Europäischen Haftbefehls für verfassungswidrig erklärt hatte. Bevor auf die Verfassungsänderung eingegangen wird (4.), sollen zunächst die Implementierung des EuHB in Polen sowie das Urteil des Verfassungsgerichtshofs (2.) und dessen Rechtsfolgen (3.) in Erinnerung gerufen werden.
Prophecy, Gender, and Culture: Ellen Gould Harmon [White] and the Roots of Seventh-day Adventism
Authors: Butler Jonathan M. 
Published: August 2007

“… the weakest of the weak…”Ellen G. White, nee Harmon (1827-1915), is among the least known of the prophet-founders of major American religious movements. The Seventh-day Adventist prophet has received neither the celebrity nor the notoriety of Mormonism’s Joseph Smith, Shakerism’s Ann Lee, or Christian Science’s Mary Baker Eddy. Yet she deserves at least the recognition of these other sect founders. Ill, introverted, and undereducated, White ultimately asserted the most forceful influence on Seventh-day Adventism and ensured it a place among the major American sects. Her long and resourceful career as the Adventist visionary inspired the transformation of a single-minded, other-worldly, Millerite off-shoot into a complex and established denomination with wide-ranging interests in sabbatarianism, eschatology, health reform, temperance, medicine, child nurture, education, and religious liberty. Her legacy includes an impressive global network of sanitariums and hospitals and a vast educational system unparalleled in contemporary Protestantism. Her writings number eighty printed volumes, circulated among an Adventist world membership of over five million.
The Private Hopes of American Fundamentalists and Evangelicals, 1925-1975
Authors: Watt David Harrington 
Published: August 2007

Much of the best recent scholarship on conservative Protestantism in the middle decades of this Century focuses on what is sometimes called the “mainstream” of interdenominational evangelicalism. Although this variety of evangelicalism was deeply influenced by and, indeed, in some respects the direct successor to the fundamentalist movement of the 1910's, 1920's, and 1930's, it did not begin to assume its present shape until the early 1940's. The formation of the National Association of Evangelicals in 1942 is a convenient symbol of the emergence of what we now think of as constituting the evangelical mainstream.Drafting a perfect definition of this mainstream is impossible; drafting a good working description of it is not. In the present context, “evangelical mainstream” simply refers to that network of born-again Christians associated with the Billy Graham Evangelistic Association, the National Association of Evangelicals, and Campus Crusade for Christ; with schools such as the Moody Bible Institute, Füller Seminary, and Wheaton College; with publishing firms like Eerdman's and Zondervan; and with magazines such as Christianity Today, Eternity, and Moody Monthly.
Saving The Children by Killing Them: Redemptive Sacrifice in the Ideologies of Jim Jones and Ronald Reagan
Authors: Chidester David 
Published: August 2007

It became necessary to destroy the town in order to save it.U.S. Army officer, after the destruction of Ben Tre, Vietnam, 1968I ‘d rather see them lay like that than to see them have to die like the Jews did.Resident of Jonestown, GuyanaI would rather see my little girls die now, still believing in God, than have them grow up under communism and one day die no longer believing in God.Resident of California, USAWe win when we go down.Jim JonesWin one for the Gipper.Ronald Reagan
Representative Emersons: Versions of American Identity
Authors: Smith David L. 
Published: August 2007

In 1903, William James began his address to the Emerson centenary gathering at Concord with a meditation on death and memory:The pathos of death is this, that when the days of one's life are ended, those days that were so crowded with business and felt so heavy in their passing, what remains of one in memory should usually be so slight a thing…. It is as if the whole of a man's significance had now shrunk into a mere musical note or phrase, suggestive of his singularity—happy are those whose singularity gives a note so clear as to be victorious over the inevitable pity of such a diminution and abridgment.While James's abridgment of Emerson in the address that followed was unusually apt, Emerson has not been as well served by most who have attempted to call his tune.
Purgatory and the Powerful Dead: A Case Study of Native American Repatriation
Authors: Flynn Johnny P. , Laderman Gary 
Published: August 2007

… what an enhancement of the power of the living there was in this hold over the dead.… And for the Church, what a marvelous instrument of power!… Purgatory brought the Church not only new spiritual power but also, to put it bluntly, considerable profit.Throughout history, human communities have converted the dead into sources of living power by grafting symbolic structures onto them and their places of interment. The impact of these structures on society, however, indicates that the “dead” are understood as more than physical remains. The dead can be imagined also as memories, spirits, or deities, and the physical or spiritual locations where they reside are essential to the vitality of the symbolism. When the dead are symbolized and carefully integrated into cultural and/or religious systems, they can become a potent source of political power for those who control the meaning of the dead and their physical remains. For this reason, the dead—especially their tombs and remains—have historically been a valuable commodity in the religious and cultural marketplace.
The Power of Interpretation: The Revival of 1857-58 and the Historiography of Revivalism in America
Authors: Long Kathryn T. 
Published: August 2007

For quite some time Timothy L. Smith and J. Edwin Orr have been nudging other historians to sit up and take notice of a revival that is so haphazardly interpreted that there exists little unanimity on what even to call it.So began a 1982 essay by Leonard Sweet on the Revival of 1857-58, an event usually remembered for its widely publicized urban prayer meetings. As Sweet alluded, lack of consensus on what to call this revival reflected only the tip of an iceberg of interpretative confusion. In addition to what they should title it, historians have differed over where the revival began, how long it lasted, which regions of the country were involved, its religious and cultural significance, and even whether anything happened that actually had significance worthy of academic investigation.
Song and Dance: Native American Religions and American History
Authors: Sullivan Lawrence E. 
Published: August 2007

What are some recent works on Native American religions that make good additions to courses on American History? With this question, the editors framed their charge for this review. This is a good moment to pose such a question because of the recent upsurge in publishing on the subject of Native American religious life. The treatment of some recent books is outlined in three stages that cover three ways of including Native American religions in courses: framing questions, case study, and key themes.Of course, teachers teach best within the compass of their own interests. This is where their passions reside and where there is the deepest motivation to communicate clearly with others. There is much to be interested in and passionate about in the recent publications on Native American religions.