bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ensayo bibliográfico sobre la propuesta pedagógica y docente del informe de la UNESCO Reimaginar juntos nuestros futuros: un nuevo contrato social para la educación
Authors: Meza-Cortés Ana Fabiola 
Published: March 2024

En este artículo presentamos un ensayo bibliográfico del informe: Reimaginar juntos nuestros futuros: un nuevo contrato social para la educación publicado en el 2022 por la UNESCO. Esto continúa la tradición de este organismo de elaborar informes prospectivos sobre la educación desde una perspectiva global. A través de un proceso de análisis, se valora específicamente los capítulos tres, cuatro y cinco. Estos se centran, respectivamente, en la necesidad de pedagogías cooperativas y solidarias, en los conocimientos comunes, en los planes de estudio y en el trabajo transformador del profesorado.
En el texto se resalta la urgencia de llevar a cabo un nuevo contrato social que permita que el conocimiento y el aprendizaje moldeen el destino futuro de la humanidad y del planeta. Este propósito demanda reconocer a la educación como un bien público y como un proyecto político construido con la participación equitativa de todas las personas.
ФОНДИ ГАЛУЗЕВОГО ДЕРЖАВНОГО АРХІВУ МІНІСТЕРСТВА ОБОРОНИ УКРАЇНИ ЯК ДЖЕРЕЛО ВИВЧЕННЯ СОЦІАЛЬНОГО ЗАХИСТУ ВІЙСЬКОВОСЛУЖБОВЦІВ ТА ЧЛЕНІВ ЇХНІХ СІМЕЙ
Authors: АВТУШЕНКО Ірина , АВТУШЕНКО Олександр 
Published: March 2024

У статті проаналізовано фонди Галузевого державного архіву Міністерства оборони України, що сприяє більш ґрунтовному дослідженню системи соціального захисту військовослужбовців та членів їхніх сімей у 1991–2014 роках, зокрема двох взаємозалежних складових: гуманітарно-правової та матеріальної. Уперше було класифіковано та введено до наукового обігу значний масив маловідомих документів і матеріалів, що зберігаються у фондах архіву, використання яких дало змогу більш повно дослідити соціальний захист військовослужбовців Збройних Сил України та членів їхніх сімей.
ОРГАНІЗАЦІЙНО-ФУНКЦІОНАЛЬНИЙ РОЗВИТОК ІНФОРМАЦІЙНО-МЕДІЙНИХ СТРУКТУР ЗБРОЙНИХ СИЛ РОСІЙСЬКОЇ ФЕДЕРАЦІЇ (1991–2022 рр.)
Authors: ПОРОНЮК Роман , ГАПЕЄВА Ольга 
Published: March 2024

У статті розглядається організаційно-функціо­нальний розвиток інформаційно-медійних структур збройних сил російської федерації у період 1991–2022 рр. Основна увага зосереджена на історичних передумовах виникнення, завданнях та напрямах діяльності. Розглянуто процес їх трансформації та підготовки для ведення війн у Чечні, Дагестані, Грузії, Україні у визначеному часопросторі від створення до початку повномасштабного вторгнення російської федерації в Україну.Досліджено діяльність підрозділів інформаційного забезпечення міністерства оборони, генерального штабу, округів, флотів, дивізій. Проаналізовано штати військових газет, журналів, радіо-, телебачення та інших структур, що активно діють в інформаційно-медійній площині.
ІСТОРИКО-ФОЛЬКЛОРНИЙ ОБРАЗ КОЗАКА МАМАЯ ЯК СИМВОЛ ТЯГЛОСТІ НАЦІОНАЛЬНОЇ ВІЙСЬКОВОЇ ТРАДИЦІЇ У РЕПРЕЗЕНТАЦІЇ СУЧАСНОЇ УКРАЇНСЬКОЇ КАРИКАТУРИСТИКИ
Authors: ПИТЛЬОВАНА Лілія 
Published: March 2024

У статті досліджено використання образу героя традиційної народної картини козака Мамая у репрезентації дій ЗС України у боротьбі з російською агресією, виявлено особливості його контекстуалізації у перебіг російсько-українського протистояння, актуалізації сюжету і його символіки у сучасній українській карикатуристиці.На основі аналізу карикатур продемонстровано, як актуалізований образ Мамая підкреслює тяглість бойового і духовного досвіду ЗС України із бойовим минулим козацтва. Виявлено художні прийоми та символічні метафори, за допомогою яких карикатуристи вписують сюжет про козака Мамая у поточні воєнні наративи. Доведено, що збірний образ козака Мамая — військовослужбовця ЗС України поєднує у собі спільні бойові, духовні і моральні характеристики, притаманні борцям за волю України обох історичних періодів.
PENERAPAN MODEL PEMBELAJARAN KOOPERATIF TIPE JIGSAW UNTUK MENINGKATKAN AKTIVITAS DAN HASIL BELAJAR IPA PADA KONSEP PENCEMARAN LINGKUNGAN
Authors: Suparman Suparman , Wondal Rosita , Djamrud Susilawati 
Published: March 2024

Model pembelajaran kooperatif tipe Jigsaw merupakan model pembelajaran kooperatif, dengan siswa belajar dalam kelompok kecil yang terdiri dari 4â€“6 orang secara heterogen dan bekerjasama saling ketergantungan yang positif dan bertanggung jawab atas ketuntasan bagian materi pelajaran yang harus dipelajari dan menyampaikan materi tersebut kepada anggota kelompok yang lain. Tujuan penelitian ini adalah untuk mengetahui aktivitas dan hasil belajar siswa kelas VII SMP Negeri I Sahu, melalui penerapan model pembelajaran kooperatif tipe jigsaw, pada materi pencemaran lingkungan. Hasil dan analisis data menunjukkan bahwa penerapan model pembelajaran kooperatif tipe jigsaw pada materi pencemaran lingkungan dapat meningkatkan aktivitas dan hasil belajar siswa kelas VII SMPN I Sahu tahun pelajaran 2013/2014 pada materi pencemaran lingkungan. Presentase aktivitas belajar siswa pada siklus I sebesar 51,82% meningkat menjadi 83,32% pada siklus II. Sedangkan presentase ketuntasan belajar pada siklus I di peroleh Â nilai rata-rata Â 16,85Â % Â kemudian Â meningkat Â dengan Â nilai rata-rata tes Â siklus Â II yaituÂ 81,45%. Sedangkan nilai presentase aktivitas guru dalam melaksanakan pembelajaran dengan model jigsaw pada siklus I mencapai 90,47% dan siklus II mencapai 100%.Â Kata kunci: jigsaw, SMPN 1 Sahu, pencemaran lingkungan
PENGARUH MEDIA PEMBELAJARAN COMPUTER ASSISTED INSTRUCTION (CAI) TERHADAP HASIL BELAJAR SISWA
Authors: Wondal Rosita 
Published: March 2024

Computer Assisted Instruction (CAI) merupakan media berbasis komputer yang digunakan untuk menyajikan materi pembelajaran, sedangkan hasil belajar siswa merupakanÂ kemampuan-kemampuan yang dimiliki siswa setelah ia menerima pengalaman belajarnya.Jenis penelitian yang digunakan adalah eksperimen, sedangkan desain penelitian adalah eksperimen dan kontrol tipe post-test dan pre-test kelompok ekuivalen. Sampel dalam penelitian ini siswa kelas VIII SMP Muhammadiyah I Kota Ternate dengan jumlah siswa 40 orang.Hasil penelitian menunjukkan bahwa terdapat pengaruh penggunaan media pembelajaran Computer Assisted Instruction (CAI) terhadap hasil belajar siswa pada pokok bahasan gerak pada tumbuhan dengan nilai thit ttab atau 2.53 2.093, sehingga dapat disimpulkan bahwa terdapat peningkatan nilai belajar siswa pada pokok bahasan gerak tumbuhan sebesar 41.7% dan tanpa menggunakan media pembelajaran CAI sebesar 18.9%.Â Kata Kunci: Media pembelajaran, CAI, hasil belajar, muhammadiyah, gerak tumbuhan
PENINGKATAN KEMAMPUAN BERPIKIR KREATIF SISWA MELALUI PENERAPAN MODEL PROBLEM BASED LEARNING
Authors: Suparman Suparman , Husen Dwi Nastuti 
Published: March 2024

Problem Based Learning (PBL) merupakan pembelajaran yang dilakukan dengan menghadapkan siswa pada permasalahan nyata pada kehidupan sehari-hari, sehingga siswa dapat menyusun pengetahuannya sendiri dalam memecahakan masalah dan mengupayakan berbagai macam solusinya, mendorong siswa untuk berpikir kreatif. Tujuan dari penelitian ini yaitu untuk mengetahui peningkatan berpikir kreatif siswa pada siswa kelas VII-3 SMP Negeri 12 Kota Tidore Kepulauanmelalui penerapan model pembelajaran Problem Based Learning (PBL) pada konsep pencemaran lingkungan. Metode yang dilakukan berupa Penelitian ini termasuk Penelitian Tindakan Kelas (PTK). Hasil penelitian menunjukkan bahwa, penerapan model pembelajaran Problem Based Learning dapat meningkatkan kemampuan berpikir kreatif dan hasil belajar siswa. Hal ini dibuktikan dengan adanya peningkatkan berpikir kreatif dan hasil belajar siswa di siklus I dan siklus II. Hasil berpikir kreatif siswa pada siklus I adalah 12,9 dengan kategori kreatif sedangkan pada siklus II meningkatÂ menjadi 15,1 dengan kategori sangat kreatif.Â Kata kunci :Â
Exploring biosurfactant from Halobacterium jilantaiense as drug against HIV and zika virus: fabrication, characterization, cytosafety property, molecular docking, and molecular dynamics simulation
Authors: Almuhayawi Mohammed S. , Elshafey Naglaa , Hagagy Nashwa , Selim Samy , Al Jaouni Soad K. , Sofy Ahmed R. , Samy Mennatalla , Gattan Hattan S. , Alruhaili Mohammed H. , Alharbi Mohanned Talal , Nagshabandi Mohammed K. , Tarabulsi Muyassar K. , Elnosary Mohamed E. 
Published: March 2024

Biosurfactants are surface-active molecules with unique qualities and various uses. Many microorganisms produce secondary metabolites with surface-active characteristics that serve various antiviral functions. The HIV and Zika viruses were chosen for this study because they can spread from mother to child and result in potentially fatal infections in infants. Halophilic bacteria from the Red Sea solar saltern in Egypt were screened using drop collapse, emulsification activity, and oil displacement assays to produce biosurfactants and emulsifiers. Halobacterium jilantaiense strain JBS1 was the most effective strain of the Halobacteriaceae family. It had the best oil displacement test and emulsification activity against kerosene and crude oil, respectively. Among the ten isolates, it produced the most promising biosurfactant, also recognized by the GC-MASS library. This study evaluated biosurfactants from halophilic bacteria as potential antiviral drugs. Some of the computer methods we use are molecular docking, ADMET, and molecular dynamics. We use model organisms like the HIV reverse transcriptase (PDB: 5VZ6) and the Zika virus RNA-dependent RNA polymerase (ZV-RdRP). Molecular docking and molecular dynamics make the best complexes with 5VZ6 HIV-RT and flavone (C25) and 5wz3 ZV-RdRP and ethyl cholate (C8). Testing for ADMET toxicity on the complex revealed that it is the safest medicine conceivable. The 5VZ6-C25 and 5wz3-C8 complexes also followed the Lipinski rule. They made five hydrogen bond donors and ten hydrogen bond acceptors with 500 Da MW and a 5:1 octanol/water partition coefficient. Finally, extreme settings require particular adaptations for stability, and extremophile biosurfactants may be more stable.
Exploring the neuroprotective activity of a lignanamides-rich extract in human neuroblastoma SH-SY5Y cells under dimethyl sulfoxide-induced stress
Authors: Mallardo Marta , Pacifico Severina , Piccolella Simona , Di Meo Irene , Rizzo Maria Rosaria , Daniele Aurora , Nigro Ersilia 
Published: March 2024

Introduction: Dimethyl sulfoxide (DMSO) is widely used as a diluent and/or solvent for pharmacological compounds. Furthermore, DMSO crosses the blood-brain barrier acting on the nervous system. The natural compounds phenylamides and lignanamides (LnHS) have protective effects on neuronal health, being promising neuroprotective candidates. In this scenario, we evaluated the impact of DMSO and/or LnHS on SH-SY5Y and U-87 cells, taken as in vitro model of neurons and glia.Methods: Cells were treated with DMSO and/or LnHS at different doses and proliferation (MTT and trypan blue counting, colony forming ability, autophagy, oxidative stress (NO, ROS determination) and inflammatory (IL8, IL6, TNFα mRNA expression) response was evaluated.Results: We found that DMSO reduces both neuronal and glial cell viability, while LnHS does not affect viability of SH-SY5Y cells but reduces that of U-87 cells. Therefore, we focused on SHSY5Y cells and investigated whether LnHS could counteract DMSO toxicity. LnHS partially attenuates the inhibitory effects of DMSO on cell viability and restores the colony-forming ability of SH-SY5Y cells exposed to DMSO. Furthermore, we found that co-administration of LnHS modulates the expression of SIRT3 and SOD2 enzymes, reduces nitrite release and ROS generation increasing IL-8 levels. Interestingly, co-administration of LnHS counteracts the DMSO-induced production of IL-6, while no modification in TNF-α was found.Discussion: Our study indicates LnHS as a potential feasible compound to support neuronal health as it counteracts DMSO induced cytotoxic effects by improving SH-SY5Y cells survival. Further studies are needed to clarify the molecular mechanisms underlying the LnHS biological activities.
Effect of statin add-on therapy on cardiovascular mortality
Authors: Nelson John R. , Le Viet , Anderson Jeffrey L. , Ciffone Nicole 
Published: March 2024

IntroductionCardiovascular (CV) disease remains a leading cause of mortality despite statin therapy. Statin add-on lipid-lowering therapies have been investigated for CV risk reduction, but their effect on CV mortality has not been reviewed.MethodsThis review describes CV outcomes trials of add-on therapies to statins, highlighting findings related to the primary composite CV endpoints and the more patient-centric endpoint of CV-related mortality.ResultsAdd-on ezetimibe met its primary composite CV endpoint vs. statin alone (P = 0.016); however, the individual endpoint of death from CV causes did not differ between groups. Add-on therapy with proprotein convertase subtilisin/kexin type 9 inhibitors achieved the primary composite CV endpoints in the respective CV outcomes trials for alirocumab (P &lt; 0.001) and evolocumab (P &lt; 0.001); however, neither CV outcomes trial found a difference vs. placebo in CV-related mortality. In its CV outcomes trial, icosapent ethyl added to statin therapy significantly reduced the occurrence of the primary composite CV endpoint (P &lt; 0.001) and the individual endpoint of risk of CV-related death (P = 0.03) vs. placebo. A CV outcomes trial of bempedoic acid monotherapy achieved its primary composite CV endpoint vs. placebo (P = 0.004) but not the endpoint of death from CV causes.DiscussionStatin add-on therapies achieved their CV outcomes trial composite CV endpoints. Proprotein convertase subtilisin/kexin type 9 inhibitors and icosapent ethyl have approved indications for CV risk reduction. Only add-on therapy with icosapent ethyl demonstrated a significant reduction in CV mortality in the overall intent-to-treat population, possibly due to the unique pleiotropic mechanisms of eicosapentaenoic acid independent of lipid-lowering effects.
Learning from (re)experience: What mobile eye-tracking video can help us learn about the cognitive processes of teaching
Authors: Miller Kevin F. , Correa Chris , Cortina Kai , Phelps Lauren , Chamberlain Lynn 
Published: March 2024

IntroductionClassroom teachers need to monitor a group of students varying in interest, knowledge, and behavior at the same time that they present a lesson and adapt it on the fly to student questions and understanding. Many areas of expertise are associated with special kinds of perceptual skills, and teaching presents its own perceptual challenges. We discuss the special nature of the expert looking that teachers must develop and how it relates to more general models of expertise. Standard methods of classroom video are limited in their support of teacher professional looking, and we explore an alternative using mobile eyetracking that overcomes many of these limits. The combination of mobile eyetracking records and standard video enables the participant to “re-experience” a situation in a vivid way, while also seeing things they missed the first time through.MethodsWe report a study in which pairs of novice and experienced teachers teaching the same students watched their own mobile eyetracking recordings while performing a retrospective think-aloud task.ResultsExperienced teachers were better able to describe high-level features and their significance in the lessons, while novices were more likely to talk about in-the-moment events such as things they failed to see while teaching. This is consistent with work on expertise that suggests there are both costs and benefits to expert looking.DiscussionOur results suggest that the ability to quickly grasp the meaning of a classroom situation may be associated with less awareness of some of the lower-level features on which those inferences are based. Novice and experienced teachers notice different things and have different perspectives on classroom processes; understanding the cognitive process of teachers will require combining insights from each. The methods used in this study are quickly becoming less costly and more accessible, and they have a unique role to play in research and in teacher professional development.
Predictive value of ultrasonic artificial intelligence in placental characteristics of early pregnancy for gestational diabetes mellitus
Authors: Zhou Huien , Chen Wanming , Chen Chen , Zeng Yanying , Chen Jialin , Lin Jianru , He Kun , Guo Xinmin 
Published: March 2024

BackgroundTo explore the predictive value of placental features in early pregnancy for gestational diabetes mellitus (GDM) using deep and radiomics-based machine learning (ML) applied to ultrasound imaging (USI), and to develop a nomogram in conjunction with clinical features.MethodsThis retrospective multicenter study included 415 pregnant women at 11-13 weeks of gestation from two institutions: the discovery group from center 1 (n=305, control group n=166, GDM group n=139), and the independent validation cohort (n=110, control group n=57, GDM group n=53) from center 2. The 2D USI underwent pre-processed involving normalization and resampling. Subsequently, the study performed screening of radiomics features with Person correlation and mutual information methods. An RBF-SVM model based on radiomics features was constructed using the five-fold cross-validation method. Resnet-50 as the backbone network was employed to learn the region of interest and constructed a deep convolutional neural network (DLCNN) from scratch learning. Clinical variables were screened using one-way logistic regression, with P&lt;0.05 being the threshold for statistical significance, and included in the construction of the clinical model. Nomogram was built based on ML model, DLCNN and clinical models. The performance of nomogram was assessed by calibration curves, area under the receiver operating characteristic curve (AUC) and decision curve analysis (DCA).ResultsThe AUCs for the ML model in the discovery cohort and independent validation cohort were 0.91 (0.88-0.94) and 0.86 (0.79-0.93), respectively. And 0.65 (0.59-0.71), 0.69 (0.59-0.79) for the DLCNN, 0.66 (0.59-0.72), 0.66 (0.55-0.76) for the clinical model, respectively. The nomogram exhibited the highest performance with AUCs of 0.93 (0.90-0.95) and 0.88 (0.81-0.94) The receiver operating characteristic curve (ROC) proved the superiority of the nomogram of clinical utility, and calibration curve showed the goodness of fit of the model. The DCA curve indicated that the nomogram outperformed other models in terms of net patient benefit.ConclusionsThe study emphasized the intrinsic relationship between early pregnancy placental USI and the development of GDM. The use of nomogram holds potential for clinical applications in predicting the development of GDM.
Causal relationship between Alzheimer’s disease and prostate cancer: a bidirectional Mendelian randomization analysis
Authors: Li Rongkang , Peng Lei , Deng Dashi , Li Guangzhi , Wu Song 
Published: March 2024

BackgroundPrevious observational researchers have found an inverse bidirectional link between Alzheimer’s disease (AD) and prostate cancer (PCa); yet, the causative nature of this link remains unclear. To investigate the causal interactions between AD and PCa, a bidirectional Mendelian randomization (MR) analysis was conducted.MethodsThis study comprised two Genome-Wide Association Study (GWAS) summary statistics for AD (17,008 cases and 37,154 controls) and PCa (79,148 cases and 61,106 controls) in individuals of European ancestry. The inverse-variance weighted (IVW) method was employed as the primary approach, while MR-Egger, weighted median, weighted mode, and simple mode served as supplementary methods for estimating the causal effect. To assess pleiotropy, the MR-PRESSO global test and MR-Egger regression were used. Cochran’s Q test was adopted to check heterogeneity, MR Steiger test and the leave-one-out analysis was performed to confirm the robustness and reliability of the results.ResultsThe causal association genetically inferred of AD on PCa was found using IVW (OR = 0.974, 95% CI = 0.958-0.991, p = 0.003) in forward MR analysis and the causal association genetically inferred of PCa on AD was not found using IVW (OR = 1.000, 95% CI: 0.954-1.049, P = 0.988) in reverse MR analysis. The sensitivity analysis showed that no pleiotropy and heterogeneity was observed. The leave-one-out analysis showed that the findings were not inordinately affected by any instrumental variables.ConclusionThe results of this study demonstrated an absence of bidirectional causality between AD and PCa among the European population, suggested that a genetically predicted possibility of decreased PCa risk in AD patients, and no significant genetically predicted causal effect of PCa on AD.
Photocatalytic degradation of naproxen using TiO2 single nanotubes
Authors: Sepúlveda Marcela , Musiał Joanna , Saldan Ivan , Chennam Pavan Kumar , Rodriguez-Pereira Jhonatan , Sopha Hanna , Stanisz Beata J. , Macak Jan M. 
Published: March 2024

Herein, TiO2 single-tube (TiO2 ST-NT) powders with and without magnetite Fe3O4 nanoparticles (TiO2 ST-NT@Fe3O4NPs) are presented for the first time as excellent photocatalysts for the degradation of one of the most popular non-steroidal anti-inflammatory drugs (NSAIDs), naproxen (NPX). The TiO2 ST-NT powders were synthesized by anodization followed by etching of the double wall, bending, sonication, ultra-centrifugation, and finally annealing at 600°C. A part of the obtained TiO2 ST-NT powders was decorated with Fe3O4 nanoparticles using a simple one-step decoration process. The best photocatalytic performance of TiO2 ST-NT and TiO2 ST-NT@Fe3O4NPs powders was obtained under the white light (6.2 × 10−4 s-1) and the blue light (2.7 × 10−4 s-1), respectively. During NPX photodegradation using TiO2 ST-NT powders, three main NPX transformation products (P1, P2, and P3) were detected. Upon excitation with the blue light illumination, TiO2 ST-NT@ Fe3O4NPs powders exhibited higher performance (∼80%) than TiO2 ST-NT powders (∼23%) within 1 h, resulting in an approximately three times increased photocatalytic rate constant. Moreover, under simulated sunlight conditions, TiO2 ST-NT powders demonstrated remarkable activity, achieving a 94% NPX degradation within 1 h. TiO2 ST-NT and TiO2 ST-NT@Fe3O4NPs powders represent excellent photocatalysts for NPX degradation.