bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hepatic leiomyosarcoma
Authors: Chen Karl T. K. 
Published: February 2007

AbstractA case of hepatic leiomyosarcoma is reported and the literature on smooth muscle tumors of the liver is reviewed. All 15 patients with hepatic leiomyosarcoma presented initially with hepatic or abdominal mass. About half of these patients also had abdominal pain or weight loss or both. Elevated levels of serum alkaline phosphatase, SGOT, and lactic dehydrogenase were frequent but inconsistent findings. The prognoses appeared grave, but potentially curable. All but four patients died in less than 3 years. One patient was not followed. The three patients who were alive in follow‐ups survived 8 months, 1 year, and 6.5 years, respectively, with no evidence of disease. All three surviving patients had resectable tumor and were surgically treated.
Bowel obstruction in cancer patients: Performance status as a predictor of survival
Authors: Weiss Stephen M. , Skibber John M. , Rosato Francis E. 
Published: February 2007

AbstractNinety‐five patients with known cancer who developed bowel obstruction were reviewed in an effort to evaluate the reliability of preadmission performance status as a predictor of outcome of therapy. Based on the review, a number of conclusions can be reached. Performance status, which is more easily measured than stage of disease at admission, is correlated with successful resolution of obstruction and survival. Many patients with known cancer who develop bowel obstruction have a non‐malignant cause of obstruction. Prolonged nonoperative treatment of cancer patients with bowel obstruction is unlikely to be successful and is fraught with complications.
Ewing sarcoma of the hand: Literature review and a case report of nonsurgical management
Authors: Kedar Amos , Bialik Viktor , Fishman Joseph 
Published: February 2007

AbstractA case of a 12‐year‐old girl with Ewing sarcoma of the third metacarpal bone is described. Following an incisional biopsy, radiation therapy and adjuvant chemotherapy were given. The girl is now 34 months postdiagnosis and 25 months off therapy in sustained complete remission and functionally normal right hand. Of the seven previously published cases only two are long‐term survivors (one had disarticulation, and the other resection of the fourth and fifth rays).
Ossified skeletal muscle angioma: Report of two cases
Authors: Hoag Gordon N. , Murphy Maurice M. , Major Paul A. 
Published: February 2007

AbstractOssifying skeletal muscle angiomas are relatively rare occurrences. The preoperative diagnosis is exceedingly difficult, although ossification may be reflected radiologically as a “Swiss cheese” appearance. Two patients are described whose skeletal muscle angiomas contained osseous tissue. The osseus tissue varied from microscopic foci to an abundant amount which was readily recognizable radiologically. The pathologic and radiological features are discussed and these appearances to hemangioma and lymphangioma are presented.
Primary head and neck reconstruction with a simultaneous ipsilateral pectoralis major myocutaneous flap and a deltopectoral flap
Authors: Morris Don M. , Reed William , Cunningham Marshall 
Published: February 2007

AbstractPatients with large advanced tumors of the head and neck that are resectable may be reconstructed by using the combination of an ipsilateral pectoralis major myocutaneous flap and an ipsilateral deltopectoral flap. Preoperative planning is necessary. The PM flap must be elevated and care taken not to interfere with the internal mammary perforating arteries. The lateral chest incision must be made low enough to provide adequate skin and soft tissue in the DP flap. These two flaps provide adequate tissue with a reliable blood supply to reconstruct these large defects.
Observations on the inadequately excised basal cell carcinomas
Authors: Sarma Deba P. , Griffing Craig C. , Weilbaecher Thomas G. 
Published: February 2007

AbstractWe studied 43 cases of reexcised skin where a diagnosis of “inadequately excised basal cell carcinoma” was made at the initial excision. Only 3 cases (7%) revealed microscopic residual tumor. Prior studies have shown a recurrence rate as high as 35% for “inadequately excised basal cell cancers.” Possible reasons for relatively low incidence of residual tumor in the reexcised specimens are discussed.
Impairment of thymus‐derived lymphoid cell function in patients with basal cell carcinoma
Authors: Dellon A. Lee , Elfenbein Gerald J. , Orlando Joseph C. 
Published: February 2007

AbstractThe host‐tumor relationships in 34 patients with basal cell carcinoma was investigated by characterizing thymus‐derived (T) and bone marrow‐derived (B) lymphoid subpopulations in the blood by cell surface markers and lymphoid function in vitro by proliferative responses to mitogenic and antigenic stimulation. Results were correlated with tumor stage. In patients with tumor present, the data demonstrate significantly (P < .02) decreased responsiveness of T cells to the lectin mitogens phytohemagglutinin and concanavalin A, and further demonstrate significantly decreased responsiveness of T cells to antigens (P < .001 for Candida antigen, P < .05 for Staphylococcal filtrate and Streptococcal varidase). In patients who were grossly disease free after resection of tumors, there was no significant difference in these responses from normal. These results document, for the first time, impaired T‐cell function in patients with basal cell carcinoma and suggest that the functional impairment is tumor induced.
Surgical treatment of carcinoma of the breast: III. Pathological finding and probability of relapse
Authors: Lee YEU‐TSU N. (Margaret) 
Published: February 2007

AbstractThis is a retrospective review of pathological findings of 462 patients who had mastectomy for carcinoma of the breast during 1971–1980. There is a positive correlation of size of the primary tumor and histological subtypes with the incidence of axillary nodal metastasis. Infiltrating ductal and lobular carcinoma, although less likely than medullary or colloid carcinoma to be 4 cm or greater in size, had a significantly higher incidence of nodal metastasis (and greater chance of having four or more positive nodes). Colloid carcinoma smaller than 4 cm and the less common histological subtypes (comedo, tubular, and papillary carcinomas) rarely metastasizes. Considering only carcinoma of infiltrating ductal, lobular, and medullary types, there is a progressively worsening prognosis with increasing sizes and number of positive axillary lymph nodes. In our series, dividing tumors into three arbitrary subgroups either by size (⩽ 2 cm, 2–6 cm, ⩾ 6 cm) or number of positive nodes (0–3, 4–9, ⩾ 10) gave the most significant separation of prognosis.
Cutaneous adnexal squamous carcinoma
Authors: Chen Karl T. K. 
Published: February 2007

AbstractA 46‐year‐old woman developed a squamous carcinoma of the skin that was treated with surgical excision followed by irradiation. The excised tumor showed no epidermal involvement; therefore, it was diagnosed as metastatic squamous carcinoma. However, a 4‐year disease‐free follow‐up indicates that it represents a primary skin tumor. Since the exact histogenesis is unclear, this tumor is tentatively designated “cutaneous adnexal squamous carcinoma.”
Primary pedunculated fibrosarcoma of the peritoneum: A case report
Authors: Delpero J. R. , Lieutaud R. , Dominguez C. , Guerinel G. , Carcassonne Y. 
Published: February 2007

AbstractFibrosarcoma is a primitive, mesenchymal tumor frequently arising from superficially located soft tissues. A case of a primary intraperitoneal, pedunculated fibrosarcoma is reported, initially presenting as an abdominal mass protruding into a large incisional hernia of the anterior abdominal wall. Despite total tumor resection, multiple intraperitoneal tumor nodules of varying sizes were found and resected six months and one year later. The patient died 18 months after the first surgical intervention. This case illustrates the highly malignant behavior and poor prognosis of fibrosarcomas of the peritoneum.
Non‐spore‐forming clostridial bacteremia
Authors: Grasberger Robert C. , Pietrafitta Joseph J. , Deckers Peter J. 
Published: February 2007

AbstractThe significance of the non‐spore‐forming clostridium as a blood‐borne pathogen has been underemphasized. Over a 7‐year period, these bacteria were cultured 40 times in 30 patients. Overall mortality rate for non‐spore‐forming clostridial bacteremia was 39%. Patients with polymicrobial infections had a 58% mortality rate, while those with only clostridium in their blood had a mortality of 23%. Mortality increased as the number of positive cultures. Patients who were clinically septic at the time of their cultures fared poorly. Advanced age and underlying malignant disease were associated with increased mortality. Patients who have positive blood cultures for non‐spore‐forming clostridium are at a significant risk and should be treated aggressively.
Prognosis of skin melanoma with regional node metastases (stage II)
Authors: Cascinelli Natale , Vaglini Maurizio , Nava Maurizio , Santinami Mario , Marolda Raffaele , Rovini Dario , Clemente Claudio , Bufalino Rossaria , Morabito Alberto 
Published: February 2007

Abstract566 stage‐II melanoma patients treated at the National Cancer Institute of Milan, Italy, were analyzed to evaluate the prognosis. Among the criteria considered, four were significantly associated with survival when considered as single factors: growth pattern, levels of invasion, the number of involved lymph nodes, and the extent of metastatic growth. As regards growth pattern, the observed 5‐year survival rates were 41.9% for superficial spreading melanoma and 20.5% for nodular melanoma (P = 10−3). As regards levels, the 5‐year survival rates were as follows: level II, 20.9%; level III, 33.1%; level IV, 43.2%; level V, 10.2% (P = 10−3). Patients with a partial node metastasis had 64.5% 10‐year survival, while those with extension beyond the capsule had 32.6% 10‐year survival (P = 10−9). Patients with one metastatic node had 43.4% 10‐year survival, and patients with three or more positive nodes had 26.0% 10‐year survival (P = 10−9). Multifactorial analysis shows that growth pattern and extent of node metastases significantly affect survival (P =10−2 and P = 10−4, respectively) while the number of involved nodes turns to borderline P‐value (0.051) and the levels are no longer significant (P = 0.4).
Is mediastinal irradiation necessary for stage I testicular seminoma?
Authors: Jose Baby , Perkins Lee P. , Kays Howard , Chu Ann M. , Sharma Subhash C. 
Published: February 2007

AbstractThis study is a review of 39 patients with testicular seminoma, Stage I, treated at the Department of Radiation Oncology, James Graham Brown Cancer Center from 1959 to 1978. The age of the patients ranged from 16 to 70 years with a median of 37. Thirty‐two (82%) patients presented with swelling or mass in the testis, four patients with pain, and three patients had seminoma diagnosed incidentally. Twenty (51%) patients had the tumor on the right side and 19 (49%) patients had the tumor on the left side. All patients received irradiation to the ipsilateral inguinal, iliac, and bilateral para‐aortic nodes with “hockey stick” type fields. The majority of the patients received a midplane dose of 3,200 to 3,600 rad in 3–4 weeks time. None of the patients received prophylactic irradiation to the mediastinum and supraclavicular region. The 5‐year actuarial survival rate is 96%. There is no additional benefit in giving prophylactic irradiation to the mediastinum and supraclavicular regions in Stage I testicular seminoma. A brief review of the literature regarding the, role of prophylactic irradiation in this group of patients is done.
Seminoma in undescended testes
Authors: Jose Baby , Perkins P. Lee , Kays Howard 
Published: February 2007

AbstractThe role of cryptorchidism in testicular carcinogenesis has been of concern for many physicians for quite a long time. The probability of a malignant neoplasm developing in an undescended testicle is about 20 to 48 times greater than a normally descended testicle. In a review of 74 patients treated with a diagnosis of testicular seminoma at the Department of Radiation Oncology, University of Louisville, Louisville, Kentucky, from 1959 to 1978, six cases were identified with a history of cryptorchidism. A detailed review of these patients along with literature review is done in this paper. The different etiologic factors for tumorigenesis in this group of patients is also discussed. The importance of periodic follow‐up of these patients is also stressed in this paper.
Prolonged survival following six pulmonary resections for metastatic adrenal cortical carcinoma: A case report
Authors: Potter Dorothy A. , Strott Charles A. , Javadpour Nasser , Roth Jack A. 
Published: February 2007

AbstractA case is presented of prolonged survival following multiple thoracotomies performed for metastatic adrenal cortical carcinoma that was refractory to other treatment modalities. In selected patients with isolated metastases to the lungs, repeated surgical resection may offer the only possibility for cure or extended palliation.
Leiomyo(sarco)ma of the oesophagus
Authors: Hoekstra Harald J. , Vermey Albert , Edens Enje Th. 
Published: February 2007

AbstractLeiomy(sarco)mas of the oesophagus are rare tumours, which often cause ill‐defined disturbances in the passage of solid food. The diagnosis can be established by simple radiological examination and endoscopy. There is no infiltration of the mucosa and it is undesirable to take biopsy specimens from such tumours through intact mucosa. The treatment of choice of leiomyoma is enucleation; that of leiomyosarcoma is resection.
A case report of pancreatic metastasis of an intracranial angioblastic meningioma (Hemangiopericytoma) and a review of metastatic tumor to the pancreas
Authors: Tanabe Shun‐Ichi , Soeda Shuji , Mukai Toshikazu , Oki Shuichi , Yun Kankatsu , Miyahara Shin‐Ichi 
Published: February 2007

AbstractThe authors report a case of solitary metastasis to the pancreas from an intracranial angioblastic meningioma (hemangiopericytoma) and discuss secondary (metastatic) tumors of the pancreas. A 65‐year‐old man developed a pancreatic tumor 15 years after the craniotomy was performed for a parasagittal meningioma. Histological investigation of the pancreatic tumor excised as a biopsy on exploratory laparotomy revealed a tumor identical to the intracranial meningioma. It was concluded that the intracranial angioblastic meningioma had recurred and metastasized to the pancreas.
Surgical treatment of cavernous hemangioma of the liver
Authors: Takagi Hiroshi , Kido Choichiro , Morimoto Takeshi , Yasue Mitsumori , Kato Hisashi 
Published: February 2007

AbstractThis report describes our experiences with 12 cases of cavernous hemangioma of the liver. Eight patients were submitted to surgical procedures. Five out of eight underwent liver resections that ranged from simple excision to hepatic lobectomy. Three patients underwent hepatic artery ligation. There were no surgical deaths or any late deaths. Four more asymptomatic patients have been observed for up to 11 years (mean 4.0 years). None of the patients in this group has evidenced intensification of symptoms or any remarkable change of the size of lesions.
Primary lymphoma of the brain: A case report and review of the literature
Authors: Alic Linda , Haid Max 
Published: February 2007

AbstractA case of primary lymphoma of the brain is presented. The disease is rare and thus firm guidelines for therapy are lacking. Whole‐brain irradiation therapy, the accepted treatment of choice, when given to a dose of 5000 rads, is associated with improved survival. However, the overall prognosis is poor due to local recurrence in the central nervous system and the tumor's ability to diffusely infiltrate the meninges. Twenty‐six percent of the cases may have positive cerebrospinal fluid cytology. Whether the addition of intrathecal chemotherapy with agents such as methotrexate will improve upon the results obtained with irradiation therapy alone would be an appropriate subject for a cooperative prospective randomized study.
The significance of bone scan abnormalities in patients with primary osteogenic sarcoma
Authors: Keller Steven M. , Rosenbaum Richard C. , Rosenberg Steven A. 
Published: February 2007

AbstractThe radionuclide bone scans and medical records of 62 patients with osteogenic sarcoma were reviewed to determine the significance of abnormalities demonstrated by the initial scintigraph at sites other than the primary lesion. 94% (58/62) of patients had abnormally increased tracer uptake at sites other than the primary tumor location. Eighty percent (49/62) of patients had abnormal bone scans at the ipsilateral proximal weight bearing joints. Only two of these patients later demonstrated metastatic tumor. Sixty‐one percent (38/62) of patients had abnormal bone scans at joints distal to the primary tumor and none were due to tumor. Five patients ultimately developed osseous metastases at sites that were normal in the original scan. The majority of radionuclide bone scan abnormalities occurring at the time of diagnosis of osteogenic sarcoma at locations distant from the primary tumor site do not represent metastatic disease.
Tubular adenoma with squamous metaplasia of the sigmoid colon: A case report
Authors: Hayashi Itsuro , Katsuda Yasaburo , Muto Yukiro , Fujii Yoshio , Morimatsu Minoru 
Published: February 2007

AbstractA case of tubular adenoma with squamous metaplasia of the sigmoid colon in a 44‐year‐old female is reported. The tumor was a pedunculated polyp with a size of 1.2 × 1.7 × 1.7 cm. Histologically, the tumor showed tubular adenoma with focal squamous metaplasia. Borderline atypia was noted in a part of adenoma without squamous metaplasia and squamous component. It is supposed that squamous epithelial polyp, squamous cell carcinoma, adenosquamous carcinoma, and mucoepidermoid carcinoma may be derived from colonic adenoma with squamous metaplasia. Only six cases of the adenoma with squamous metaplasia of the large intestine have been reported previously in the literature.
Treatment of advanced invasive cervical cancer: Changing times and trends
Authors: Yoonessi Mahmood 
Published: February 2007

AbstractA retrospective analysis of the treatment results and complications in 140 patients with advanced (Stage IIB or more) invasive cervical cancer treated at the Albert Einstein College of Medicine (AECOM) from 1962–1970 and the State University of New York at Buffalo (SUNYAB) from 1974–1982 is the subject of this report. All patients were clinically staged and received external pelvic radiotherapy followed by one to two intracavitary radium insertions, and those with histologically proven positive para‐aortic nodes received on additional 4,500 to 5,000 rads to the para‐aortic areas. Forty‐four patients had pretherapy surgical staging (26 transperitoneal, 18 extraperitoneal). In the clinical staging group, a survival time of 5 years or longer was attained in 22 of 39 patients (56%); with Stage IIB, 11 of 30 patients (37%) with Stage IIIA, two of 13 patients with Stage IIIB and two of 12 patients with Stage IVA disease. Of 26 patients staged via transperitoneal approach, two survived more than 5 years and three others were alive at last contact (after more than 3 years follow‐up). The last 18 patients have been subjected to laparoscopy and retroperitoneal pelvic and para‐aortic node biopsies followed by tailored radiotherapy with [12] or without [6] chemotherapy. Chemotherapy consisted of alternating weekly courses of vincristine and bleomycin and hydroxyurea. Mitomycin‐C was added to this regimen at the conclusion of the course of radiotherapy. Only one patient developed a vesicovaginal fistula. At last contact, seven patients in the combined therapy group were alive and free of disease. Combined therapy following extraperitoneal surgical staging appears to be feasible and justifiable. It deserves further trials in larger series.
In vitro activation of cyclophosphamide for an in vitro chemosensitivity assay
Authors: Hill Helene Z. , Hill George J. 
Published: February 2007

AbstractThe problem of activation of cyclophosphamide (CY) for an in vitro chemosensitivity assay was studied using the B16 melanoma. The efficacy of the S9 hepatic microsomal fraction in vitro was compared with activation by passage of drug in vivo. The effect of CY was assayed by inhibition of tritiated thymidine (3HdThd) uptake by B16 tumor cells in vitro, and by its effect in single dose in vivo on the life span of syngeneic C57BL/6 mice injected with B16 tumor cells. In vivo activation of CY that was achieved by injecting 20 mg of CY intraperitoneally (i.p.) into mice and obtaining plasma 20 minutes later was more rapid and more reproducible, while in vitro activation provided a more potent preparation and a better quantitative correlation with the in vivo effect of CY. The activation activity of different preparations of S9 microsomal fractions was found to be directly related to the activity of aminopyrine demethylase, a mixed function oxidase enzyme, in the S9 fraction, rather than to total protein concentration. The S9‐activated drug required 2 1/2 to 3 hours to achieve maximum inhibition of subsequent tumor cell tritiated thymidine (3HdThd) incorporation compared with 20 minutes to achieve maximum inhibition by in vivo activated drug. We conclude that rapid qualitative screening for effectiveness of CY may best be done with in vivo activated drug, whereas quantitative prediction of effective concentration appears to be best achieved with drug activated in vitro by the hepatic S9 fraction.
Malignant histiocytosis in the oropharynx
Authors: Ogasawara Hiroshi , Toda Fuki , Kumoi Takeo , Sawada Yukio , Mitsunobu Masao , Uematsu Kunio 
Published: February 2007

AbstractMalignant histiocytosis is characterized by systemic, progressive, and invasive proliferation of malignant histiocytes. The disorder is typically accompanied by fever, general fatigue, lymphadenopathy, and hepatosplenomegaly. A case of a 21‐year‐old woman with primary malignant histiocytosis of the oropharynx is reported. Histologic diagnosis from the biopsy specimen was confused by infiltration of normal‐appearing histiocytes and inflammatory cells. The titers of Epstein‐Barr virus and the Paul‐Bunnell test were elevated without atypical lymphocytes. The patient died 3.5 months after the onset of symptoms. Autopsy revealed systemic neoplastic proliferation of malignant histiocytes. A review of literature on this subject revealed no cases of malignant histiocytosis primarily involving the oropharynx.
Comparison of patient profiles from a comprehensive cancer center and the general population
Authors: Mettlin Curtis , Aungst C. William , Michalek Arthur M. , Lane Warren , Gamble Dolores 
Published: February 2007

AbstractDifferences in cancer patient profiles between cases seen at comprehensive cancer centers and those seen in the general population are seldom assessed by means of reliable and systematically collected data. This report compares the characteristics of patients treated at Roswell Park Memorial Institute in Buffalo with all reported patients diagnosed in the Western New York population. Data for this study were generated from the Roswell Park Tumor Registry and the Western New York Tumor Registry. The findings indicate that patients presenting for treatment at Roswell Park Memorial Institute, compared to the WNY cancer patient population, are more frequently diagnosed with rare tumors, are younger, and manifest later stage disease. These data may have implications for the planning and evaluation of cancer patient services at the community level.