bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hypoxia‐inducible factor 1α is involved in the prostaglandin metabolism of osteoarthritic cartilage through up‐regulation of microsomal prostaglandin E synthase 1 in articular chondrocytes
Authors: Grimmer C. , Pfander D. , Swoboda B. , Aigner T. , Mueller L. , Hennig F. F. , Gelse K. 
Published: November 2007

AbstractObjectiveTo investigate crosslinks between catabolic and anabolic pathways in articular cartilage by examining the synthesis and distribution pattern of microsomal prostaglandin E synthase 1 (mPGES‐1) in healthy and osteoarthritic (OA) cartilage and analyzing its functional relationship to hypoxia‐inducible factor 1α (HIF‐1α) in primary articular chondrocytes.MethodsNormal cartilage and OA cartilage were subjected to immunohistochemical staining for mPGES‐1 and HIF‐1α. Isolated chondrocytes were cultivated under 21% or 1% O2. Microarray analysis and quantitative reverse transcriptase–polymerase chain reaction were used to detect genes differentially expressed in chondrocytes cultured under normoxic compared with hypoxic conditions. Immunoblotting was conducted to evaluate intracellular protein levels of mPGES and nuclear accumulation of HIF‐1α under different oxygen tension levels and with different stimulatory or inhibitory chemical agents.ResultsWe found enhanced levels of expression of the mPGES‐1 gene and an increased number of OA chondrocytes showing staining for mPGES‐1 in OA cartilage. Microarray analysis demonstrated that mPGES‐1 was among the genes that were up‐regulated to the greatest degree in primary chondrocytes exposed to 1% O2. In vitro, hypoxia led to an enhanced synthesis of mPGES‐1, coinciding with a nuclear accumulation of the transcription factor HIF‐1α. In chondrocyte culture, stimulation with dimethyloxaloylglycine promoted the expression of mPGES‐1, phosphoglycerate kinase 1, and cyclooxygenase 2 (COX‐2) by stabilizing HIF‐1α protein levels. A reduction of mPGES‐1 synthesis was detected after treatment with 2‐methoxyestradiol, correlating with lower HIF‐1α activity. In contrast, synthesis of mPGES‐1 was not influenced by treatment with the specific COX‐2 inhibitor NS398.ConclusionThese findings suggest that the transcription factor HIF‐1α is involved in the up‐regulation of mPGES‐1 and may therefore play an important role in the metabolism of OA cartilage.
Articular cartilage and biomechanical properties of the long bones in Frzb‐knockout mice
Authors: Lories Rik J. U. , Peeters Jenny , Bakker Astrid , Tylzanowski Przemko , Derese Inge , Schrooten Jan , Thomas J. Terrig , Luyten Frank P. 
Published: November 2007

AbstractObjectiveLigands and antagonists of the WNT pathway are linked to osteoporosis and osteoarthritis. In particular, polymorphisms in the FRZB gene, a secreted WNT antagonist, have been associated with osteoarthritis. The aim of this study was to examine cartilage and bone in Frzb−/− mice.MethodsThe Frzb gene in mice was inactivated using a Cre/loxP strategy. Three models of osteoarthritis were used: collagenase, papain, and methylated bovine serum albumin induced. Bone biology was studied using density measurements and microfocal computed tomography. Bone stiffness and mechanical loading–induced bone adaptation were studied by compression of the ulnae.ResultsTargeted deletion of the Frzb gene in mice increased articular cartilage loss during arthritis triggered by instability, enzymatic injury, or inflammation. Cartilage damage in Frzb−/− mice was associated with increased WNT signaling and matrix metalloproteinase 3 (MMP‐3) expression and activity. Frzb−/− mice had increased cortical bone thickness and density, resulting in stiffer bones, as demonstrated by stress–strain relationship analyses. Moreover, Frzb−/− mice had an increased periosteal anabolic response to mechanical loading as compared with wild‐type mice.ConclusionThe genetic association between osteoarthritis and FRZB polymorphisms is corroborated by increased cartilage proteoglycan loss in 3 different models of arthritis in Frzb−/− mice. Loss of Frzb may contribute to cartilage damage by increasing the expression and activity of MMPs, in a WNT‐dependent and WNT‐independent manner. FRZB deficiency also resulted in thicker cortical bone, with increased stiffness and higher cortical appositional bone formation after loading. This may contribute to the development of osteoarthritis by producing increased strain on the articular cartilage during normal locomotion but may protect against osteoporotic fractures.
Treg cells suppress osteoclast formation: A new link between the immune system and bone
Authors: Zaiss Mario M. , Axmann Roland , Zwerina Jochen , Polzer Karin , Gückel Eva , Skapenko Alla , Schulze‐Koops Hendrik , Horwood Nikki , Cope Andrew , Schett Georg 
Published: November 2007

AbstractObjectiveTo investigate whether Treg cells can suppress osteoclast differentiation, and to define a new potential link between the immune system and the skeleton.MethodsRegulatory CD4+,CD25+,Foxp3+ T cells were isolated and purified from the spleen and cocultured with CD11b+ osteoclast precursor cells isolated from bone marrow. Osteoclastogenesis and bone erosion were assessed by tartrate‐resistant acid phosphatase staining and pit resorption assay, respectively. In addition, Transwell experiments and cytokine‐blocking experiments were performed to define the mechanisms of interaction between Treg cells and osteoclasts.ResultsCD4+,CD25+,Foxp3+ T cells, but not CD4+,CD25− T cells, dose dependently inhibited macrophage colony‐stimulating factor– and RANKL‐dependent osteoclast formation. Pit formation was inhibited by up to 80% when Treg cells were added. The blockade of osteoclast formation was not based on the alteration of RANKL/osteoprotegerin balance but was essentially dependent on direct cell–cell contact via CTLA‐4. Treg cell–mediated expression of transforming growth factor β, interleukin‐4 (IL‐4), and IL‐10 contributed but was not essential to the inhibitory effect on osteoclastogenesis.ConclusionThese data show that CD4+,CD25+,Foxp3+ Treg cells suppress osteoclast formation, provide a new link between the immune system and bone, and extend our knowledge on regulation of bone homeostasis by the immune system.
Reflections on training in child abuse and neglect prevention: Experiences in Brazil
Authors: Lidchi Victoria Gabrielle 
Published: November 2007

AbstractIn cooperation with an international partner, Brazilian professionals based in Rio de Janeiro designed a training programme in child protection to respond to the particular challenges to effective practice posed by the local environment and to address obstacles to its achievement in the existing child protection system. Training participants used a structured process to identify and address such external challenges and internal obstacles. The use of the framework included an exploration of beliefs held by Brazilian child protection professionals. The training was itself envisaged as an intervention opportunity for participants to promote ‘bottom up’ processes of local systemic change. The programme aimed to provide training that accessed the experience of the international partner's ‘community of expertise’, but mitigated the risk to effectiveness of a ‘transplant’ programme that fails to engage with the surrounding social reality and culture. As part of a nine‐country international training project initiative (ITPI, International Training Project Initiative by ISPCAN) sponsored by the International Society for the Prevention of Child Abuse and Neglect (ISPCAN), standardised tools were adopted to monitor and evaluate the training process. Copyright © 2007 John Wiley & Sons, Ltd.
‘Don't grind an egg against a stone’— children's rights and violence in Cambodian history and culture
Authors: Miles Glenn , Thomas Nigel 
Published: November 2007

AbstractCambodia is a society with a troubled history, and one that is struggling to find a way between traditional and modern values. This paper considers some of the challenges in promoting children's rights to protection in such a context. It briefly considers the historical and cultural background, and the possible implications for how different forms of violence involving children are experienced. A feature of the analysis is a method for representing in graphic form the historical circumstances in which different cohorts of children have passed their childhoods. The paper goes on to report findings from a study of children's experiences and beliefs about different kinds of violence and ill‐treatment, in which a survey of secondary school children throughout Cambodia was supplemented by focus groups in selected areas. The paper concludes by asking how children's views can be effectively expressed in this particular cultural context, and how research based on those views can be used to influence policy and practice. Copyright © 2007 John Wiley & Sons, Ltd.
Clinical and angiographic results of percutaneous coronary revascularization using a trilayer stainless steel‐tantalum‐stainless steel phosphorylcholine‐coated stent: The TriMaxx trial
Authors: Abizaid Alexandre , Popma Jeffrey J. , Tanajura Luis F. , Hattori Kyoko , Solberg Brad , Larracas Cristina , Feres Fausto , Costa José de Ribamar , Schwartz Lewis B. 
Published: November 2007

AbstractBackground:The TriMaxx™ coronary stent system includes a novel trilayer metal stent having two outer layers of 316L stainless steel and with an inner 0.0007 inches layer of tantalum. This enables creation of a maximally flexible and thin device (0.0029 inches) while still maintaining the requisite strength and radiopacity for effective implantation.Objectives:The objective of this multi‐center, single‐arm prospective clinical trial was to assess the safety and performance of the TriMaxx stent for the treatment of single de novo coronary artery lesions.Methods:One hundred patients with ischemic coronary occlusive disease because of single de novo obstructive lesions of native coronary arteries were treated with 3 × 15 or 3 × 18 mm TriMaxx stents in four hospitals in Brazil and Germany between May of 2004 and September of 2005. An independent core laboratory analyzed the quantitative coronary angiography (QCA) results immediately after stent implantation, and after six months.Results:The lesion, procedure, and device‐deployment success rates were 100, 99, and 100%, respectively. Eighty‐eight patients underwent follow‐up angiography at 6 ± 1 months. After six months, 13 (13%) of patients had sustained major adverse cardiac events, including 9.0% that required target lesion revascularization (TLR). The follow‐up angiographic studies revealed a binary in‐stent restenosis rate of 25% with in‐stent late lumen loss of 0.94 ± 0.57 mm.Conclusions:These results demonstrate that the TriMaxx stent can be safely deployed for the treatment of single de novo coronary occlusive lesions with six‐month clinical and angiographic results rates comparable to historical results using other bare metal stents. © 2007 Wiley‐Liss, Inc.
Synthesis and Single Crystal Structures of Ternary Phosphides Li4SrP2 and AAeP (A: Li, Na; A: Sr, Ba).
Authors: Dong Yongkwan , DiSalvo Francis J. 
Published: November 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Three‐Dimensional Framework of Uranium‐Centered Polyhedra with Non‐Intersecting Channels in the Uranyl Oxyvanadates A2(UO2)3(VO4)2O (A: Li, Na).
Authors: Obbade S. , Duvieubourg L. , Dion C. , Abraham F. 
Published: November 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Crystal Chemistry of M[PO2(OH)2]2×2H2O Compounds (M: Mg, Mn, Fe, Co, Ni, Zn, Cd): Structural Investigation of the Ni, Zn and Cd Salts.
Authors: Koleva Violeta , Effenberger Herta 
Published: November 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Quantum Chemical and Spectroscopic Analysis of Calcium Hydroxyapatite and Related Materials.
Authors: Khavryuchenko V. D. , Khavryuchenko O. V. , Lisnyak V. V. 
Published: November 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Chemical Bonding in EuTGe (T: Ni, Pd, Pt) and Physical Properties of EuPdGe.
Authors: Rocquefelte Xavier , Gautier Regis , Halet Jean‐Francois , Muellmann Ralf , Rosenhahn Carsten , Mosel Bernd D. , Kotzyba Gunter , Poettgen Rainer 
Published: November 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
High‐Pressure Phase Transition in LiBH4.
Authors: Talyzin A. V. , Andersson O. , Sundqvist B. , Kurnosov A. , Dubrovinsky L. 
Published: November 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
High‐Pressure Synthesis, Crystal Structure, and Properties of the First Ternary Hafniumborate β‐HfB2O5.
Authors: Knyrim Johanna S. , Huppertz Hubert 
Published: November 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
High‐Yield Synthesis and Characterization of Monodisperse Sub‐Microsized CoFe2O4 Octahedra.
Authors: Liu Xian‐Ming , Fu Shao‐Yun , Zhu Lu‐Ping 
Published: November 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis, Structure, and Physicochemical Investigations of the New α Cu0.50TiO(PO4) Oxyphosphate.
Authors: Benmokhtar S. , Belmal H. , El Jazouli A. , Chaminade J. P. , Gravereau P. , Pechev S. , Grenier J. C. , Villeneuve G. , de Waal D. 
Published: November 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Sequential Enantioselective, Organocatalytic Route to Chiral 1,2‐Oxazines and Chiral Pyridazines.
Authors: Kumarn Sirirat , Oelke Alexander J. , Shaw David M. , Longbottom Deborah A. , Ley Steven V. 
Published: November 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Asymmetric Hydrogenation Routes to Deoxypolyketide Chirons.
Authors: Zhou Jianguang , Ogle James W. , Fan Yubo , Banphavichit Vorawit , Zhu Ye , Burgess Kevin 
Published: November 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Tandem Metal‐ and Organocatalysis in Sequential Hydroformylation and Enantioselective Aldol Reactions.
Authors: Chercheja Serghei , Eilbracht Peter 
Published: November 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Nucleophilic Substitution Reactions of Alcohols with Use of Montmorillonite Catalysts as Solid Broensted Acids.
Authors: Motokura Ken , Nakagiri Nobuaki , Mizugaki Tomoo , Ebitani Kohki , Kaneda Kiyotomi 
Published: November 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Transformation of Perfluorinated Benzocycloalkenes and Alkylbenzenes to Their Carbonyl Derivatives under the Action of CF3COOH/SbF5.
Authors: Zonov Yaroslav V. , Karpov Victor M. , Platonov Vyacheslav E. 
Published: November 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Gold(I)‐Catalyzed Regioselective Cyclizations of Silyl Ketene Amides and Carbamates with Alkynes.
Authors: Minnihan Ellen C. , Colletti Steven L. , Toste F. Dean , Shen Hong C. 
Published: November 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Metal‐Catalyzed Regiodivergent Cyclization of γ‐Allenols: Tetrahydrofurans versus Oxepanes.
Authors: Alcaide Benito , Almendros Pedro , Martinez del Campo Teresa 
Published: November 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Rh(I)‐Catalyzed Conjugate Addition of Alkenylzirconocene Chloride: Stereoselective Formation of Carbocycles Through Cascade Reaction.
Authors: Hanzawa Yuji , Takebe Yoshitaka , Saito Akio , Kakuuchi Akito , Fukaya Haruhiko 
Published: November 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Magnetically Separable Pd Catalyst for Highly Selective Epoxide Hydrogenolysis under Mild Conditions.
Authors: Kwon Min Serk , Park In Soo , Jang Jum Suk , Lee Jae Sung , Park Jaiwook 
Published: November 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Rhodium and Iridium Nanoparticles Entrapped in Aluminum Oxyhydroxide Nanofibers: Catalysts for Hydrogenations of Arenes and Ketones at Room Temperature with Hydrogen Balloon.
Authors: Park In Soo , Kwon Min Serk , Kang Kyung Yeon , Lee Jae Sung , Park Jaiwook 
Published: November 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Facile Synthesis of Fluoroalkenes by Palladium‐Catalyzed Reductive Defluorination of Allylic gem‐Difluorides.
Authors: Narumi Tetsuo , Tomita Kenji , Inokuchi Eriko , Kobayashi Kazuya , Oishi Shinya , Ohno Hiroaki , Fujii Nobutaka 
Published: November 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Ionic Liquid Functionalized SBA‐15 Promoted Rapid and Facile Aza‐Michael Reaction.
Authors: Wu Chuan , Xu Li‐Wen , Yang Ming‐Song , Jiang Jian‐Xiong , Qiu Hua‐Yu , Lai Guo‐Qiao 
Published: November 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Heptane‐Soluble Ring‐Closing Metathesis Catalysts.
Authors: Hongfa Chayanant , Tian Jianhua , Bazzi Hassan S. , Bergbreiter David E. 
Published: November 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
New Boron(III)‐Catalyzed Amide and Ester Condensation Reactions.
Authors: Maki Toshikatsu , Ishihara Kazuaki , Yamamoto Hisashi 
Published: November 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
CuSO4 as a Mild, Green, and Efficient Catalyzed for the One‐Pot Conversion of THP Ethers to Acetates.
Authors: Asadolah Karim , Heravi Majid M. 
Published: November 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
3‐(Perfluoroalkyl)propanols: Valuable Building Blocks for Fluorous Chemistry.
Authors: Rabai Jozsef , Szijjarto Csongor , Ivanko Peter , Szabo Denes 
Published: November 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Organocatalytic Asymmetric Nitroaldol Reaction: Cooperative Effects of Guanidine and Thiourea Functional Groups.
Authors: Sohtome Yoshihiro , Takemura Nobuko , Takada Keisuke , Takagi Rika , Iguchi Toshitsugu , Nagasawa Kazuo 
Published: November 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Organocatalytic Conjugate Addition of Formaldehyde N,N‐Dialkylhydrazones to β,γ‐Unsaturated α‐Keto Esters.
Authors: Herrera Raquel P. , Monge David , Martin‐Zamora Eloisa , Fernandez Rosario , Lassaletta Jose M. 
Published: November 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Lanthanum Metal Assisted Cylopropanation of Alkenes with gem‐Dihaloalkanes.
Authors: Nishiyama Yutaka , Tanimizu Hana , Tomita Tsuyoshi 
Published: November 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Asymmetric Catalytic Intramolecular Pauson—Khand Reactions with Ir(phox) Catalysts.
Authors: Lu Zhong‐Lin , Neumann Eva , Pfaltz Andreas 
Published: November 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Bulky Thioureas as New Ligands for Gold(I)‐Catalyzed Cyclization of Acetylenic 1,3‐Dicarbonyl Compounds.
Authors: Pan Jie‐Hui , Yang Min , Gao Qiang , Zhu Nian‐Yong , Yang Dan 
Published: November 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Gold(I)‐Catalyzed Asymmetric Cycloisomerization of Eneallenes into Vinylcyclohexenes.
Authors: Tarselli Michael A. , Chianese Anthony R. , Lee Stephen J. , Gagne Michel R. 
Published: November 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A New Facile Synthesis of 1,1‐Dibromo‐2‐arylethenes.
Authors: Pawluc Piotr , Hreczycho Grzegorz , Walkowiak Jedrzej , Marciniec Bogdan 
Published: November 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.