bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long‐term clinical and angiographic outcomes after implantation of sirolimus‐eluting stents with a “modified mini‐crush” technique in coronary bifurcation lesions
Authors: Yang Hyoung‐Mo , Tahk Seung‐Jea , Woo Seong‐Ill , Lim Hong‐Seok , Choi Byoung‐Joo , Choi So‐Yeon , Yoon Myeong‐Ho , Park Jin‐Sun , Zheng Mingri , Hwang Gyo‐Seung , Kang Soo‐Jin , Shin Joon‐Han 
Published: February 2009

AbstractObjectives:We aimed to evaluate long‐term outcomes of a modified mini‐crush technique for treating bifurcation lesions.Background:Coronary bifurcation lesions continue to show a relatively high restenosis rate despite the use of a drug‐eluting stent (DES).Methods:We enrolled 52 consecutive patients treated with sirolimus‐eluting stent implantation using the modified mini‐crush technique for 56 coronary bifurcation lesions (MEDINA 1, 1, 1, 89.2%; left main lesion, 28.6%). To minimize crushing, the proximal marker of the side branch (SB) stent was located in contact with the main vessel (MV) stent. After SB stenting, we drew the SB balloon proximally and dilate the SB ostium at a rated burst pressure. After MV stenting, both vessels were redilated at a high pressure before final kissing balloon (FKB) inflation. Clinical and angiographic follow‐ups were performed at 9 months.Results:Immediate procedural success was obtained in all cases including a FKB success rate of 98%. At 9 months, there was no death or myocardial infarction. The incidences of major adverse cardiac events and target lesion revascularization were 11.8 and 7.8%, respectively. The in‐stent restenosis (ISR) rate was 14.9% (SB ostium, 10.6%) and most ISRs were of the focal type and the cause of ISR was intimal hyperplasia but not chronic stent recoil by an intravascular ultrasound study. There was one case (2.0%) of late stent thrombosis without any ischemic symptoms during the follow‐up period of 9 months.Conclusions:Modified mini‐crush technique provides excellent technical and angiographic success immediately and it also provides acceptable long‐term outcomes. © 2009 Wiley‐Liss, Inc.
Antiplatelet therapy in percutaneous coronary intervention: A critical review of the 2007 AHA/ACC/SCAI guidelines and beyond
Authors: Cohen Marc 
Published: February 2009

AbstractAntiplatelet therapy is a mainstay in the treatment of patients who have undergone percutaneous coronary intervention (PCI). Although the 2007 PCI treatment guidelines were published by the American College of Cardiology, the American Heart Association, and the Society for Cardiovascular Angiography and Interventions, new clinical evidence has emerged, expanding our understanding of antiplatelet use and potentially affecting the treatment guidelines. For example, clinical trial results prompted a Science Advisory to recommend that dual therapy with aspirin and clopidogrel be used for longer periods—up to 1 year in patients who receive bare metal stents and at least 1 year in patients receiving drug‐eluting stents. New trial results have also emerged regarding the use of glycoprotein IIb/IIIa antagonists such as abciximab, eptifibatide, and tirofiban. This article reviews the current recommendations for antiplatelet therapy in PCI patients, recent trial results, newly developed agents, ongoing clinical trials, and the future direction of antiplatelet therapy in patients who undergo PCI. © 2009 Wiley‐Liss, Inc.
Development of animal model for calcified chronic total occlusion
Authors: Suzuki Yoriyasu , Oyane Ayako , Ikeno Fumiaki , Lyons Jennifer K. , Yeung Alan C. 
Published: February 2009

AbstractChronic total coronary occlusion (CTO) remains a major problem for percutaneous revascularization, with relatively low primary success rates and a high incidence of restenosis and reocclusion compared with those of subtotal stenoses. No reproducible animal model simulating human CTOs has previously been developed. We hypothesized that an apatite‐coated bioabsorbable polymer sponge could be implanted to produce calcified CTO lesions in animal coronary arteries/peripheral arteries. A total of 10 swine and six rabbits were used for this study. The apatite‐coated bioabsorbable polymer sponges were implanted into a preselected segment of coronary and peripheral arteries. Four weeks after implantation, both angiography and histopathology were performed to document the presence or absence of CTO lesions. We could reproducibly develop CTO lesions in animal coronary/peripheral arteries that mimic human CTO lesions. These lesions were found to have microvascular channels and microcalcification similar to those of human older CTO lesions and demonstrate the development of adventitial arterioles, a consistent finding in human CTO. This CTO model might provide a platform for evaluating future CTO technologies as well as contributing to a better understanding of CTOs in both educational and practical terms. © 2009 Wiley‐Liss, Inc.
Application of recurrent relationships in chromatography
Authors: Zenkevich Igor G. 
Published: February 2009

AbstractRecurrent relationships of general form A(x + k) = aA(x) + b were shown to be applicable to the approximation not only of values of most physicochemical constants of organic compounds (A) indicating monotonous or oscillating variations within different homologous series (x = nC, k = 1 or 2), but also of the dependences of chromatographic retention parameters on the number of carbon atoms in homologue molecules (A = tR, x = nC) in gas and high performance liquid chromatography (HPLC). In these cases the values of argument (the number of carbon atoms in the molecule) are integer by definition, while the functions are discrete. Besides that, the same recurrent equations describe the temperature dependence of retention times of analytes under isothermal separation conditions in gas chromatography (A = tR, x = T, k = ΔT = const) and the dependences of retention times on the concentrations of an organic solvent as an eluent component (A = tR, x = C, k = ΔC = const) under isocratic separation conditions in HPLC, which are the examples of the functions of continuous arguments. Key mathematical properties of recurrences explaining us their promising applications in chemistry and chromatography are discussed. The method to apply recurrent equations to arbitrary, not necessary equidistant, values of continuous arguments is considered. Copyright © 2009 John Wiley & Sons, Ltd.
Dual Amino‐Functionalised Phosphonium Ionic Liquids for CO2 Capture
Authors: Zhang Yanqiang , Zhang Suojiang , Lu Xingmei , Zhou Qing , Fan Wei , Zhang XiangPing 
Published: February 2009

AbstractCO2 is locked up: Dual amino‐functionalised phosphonium ionic liquids (ILs; see figure) have been prepared. The ILs have excellent thermal properties, such as low glass transition temperatures and high thermal decomposition temperatures. The supported CO2 absorption of four of the ILs on porous SiO2 was found to approach one mol CO2 per mol IL, a factor of two greater than that reported before.magnified imageA series of 20 dual amino‐functionalised phosphonium ionic liquids, (3‐aminopropyl)tributylphosphonium amino acid salts ([aP4443][AA], in which [AA]−=[Ala]−, [Arg]−, [Asn]−, [Asp]−, [Cys]−, [Gln]−, [Glu]−, [Gly]−, [His]−, [Ile]−, [Leu]−, [Lys]−, [Met]−, [Phe]−, [Pro]−, [Ser]−, [Thr]−, [Trp]−, [Tyr]− and [Val]−), has been prepared. Their physicochemical properties, such as density, viscosity, glass transition and thermal decomposition temperatures and conductivity, have been determined. In particular, the [aP4443][AA] ionic liquids (ILs) have low glass transition temperatures ranging from −69.7 to −29.6 °C and high decomposition temperatures (all above 200 °C). The effects of the variation of the structure of [AA]− on the above physicochemical properties are discussed. Furthermore, the CO2 absorption of [aP4443][Gly], [aP4443][Ala], [aP4443][Val] and [aP4443][Leu], taken as examples, was investigated. It was found that the supported absorption of CO2 by the [aP4443][AA] ILs almost reaches equilibrium within 80 min, the chemical absorption of CO2 by the [aP4443][AA] ILs approaches 1 mol CO2 per mol ionic liquid (twice that reported before) and the [aP4443][AA] ILs can be repeatedly recycled for CO2 uptake.
Synthesis and Conformational Analysis of (α‐D‐Galactosyl)phenylmethane and α‐,β‐Difluoromethane Analogues: Interactions with the Plant Lectin Viscumin
Authors: Kolympadi Maria , Fontanella Marco , Venturi Chiara , André Sabine , Gabius Hans‐Joachim , Jiménez‐Barbero Jesús , Vogel Pierre 
Published: February 2009

AbstractTo bend about: The conformations of three phenyl‐C‐galactosides in solution were evaluated by using theoretical calculations and NMR spectroscopic studies. The α‐CF2 derivative (see scheme) showed significant flexibility of the pyranose ring and around the pseudoanomeric center, whereas the other two analogues more closely resemble the natural galactosides. Regardless, all three compounds bind to a plant lectin.magnified image(α‐D‐Galactosyl)phenylmethane (1), (α‐ and β‐D‐galactosyl)(difluoro)phenylmethane (2 and 3) have been prepared and their conformations in solution were described by using a combination of force‐field calculations and NMR spectroscopic studies. Galactoside 1 adopts a 4C1 chair conformation and an exo anomeric orientation, as is the case for natural α‐galactosides. The X‐ray crystal structure of its difluoromethylene derivative 2 similarly shows a 4C1 chair conformation. Surprisingly, compound 2 exhibits a different equilibrium between 1C4 chair and 1S3 skew boat conformations and significant flexibility around the pseudoglycosidic linkage when in solution. The β‐stereoisomer 3 adopts a major 4C1 chair conformation. Interestingly, C‐galactosides 1, 2, and 3 bind to viscumin (VAA), a galactoside‐specific lectin, which is confirmed by NMR experiments and docking calculations.
Mechanistic Insight into Formation of Oxo‐Iron(IV) Porphyrin π‐Cation Radicals from Enzyme Mimics of Cytochrome P450 in Organic Solvents
Authors: Hessenauer‐Ilicheva Natalya , Franke Alicja , Meyer Dominik , Woggon Wolf‐D. , van Eldik Rudi 
Published: February 2009

AbstractTwo new models for cytochrome P450 in which the thiolate axial ligand is replaced by an RSO3− group, form oxo‐iron(IV) porphyrin π‐cation radicals as sole oxidation products in “peroxo shunt” reactions (see scheme) independent of the nature of the employed solvent (polar or non‐polar) and electronic nature of the porphyrin rings.magnified imageTwo new models for cytochrome P450 in which the thiolate axial ligand is replaced by a RSO3− group, form oxo‐iron(IV) porphyrin π‐cation radicals as sole oxidation products in “peroxo shunt” reactions independent of the nature of the employed solvent (polar or non‐polar) and electronic nature of the porphyrin rings. Although the properties of the solvent and push–pull effects from the porphyrin rings do not affect the mode of the OO bond cleavage (heterolytic or homolytic) in these models, they strongly affect the rate and mechanism of each reaction step leading to the formation of the high‐valent iron intermediates. This article reports the results of mechanistic studies involving the measurements of the rate of oxo‐iron(IV) porphyrin π‐cation radical formation from the enzyme mimics of P450 for different oxidant concentration, temperature and pressure in selected organic solvents. Extraction of the appropriate rate constants and activation parameters for the reactions studied enable a detailed discussion of the effects of solvent and electronic nature of the porphyrin rings on the position of the first pre‐equilibrium involving formation of the acylperoxo‐iron(III) porphyrin intermediate, as well as on the rate of heterolytic OO bond cleavage leading to the formation of the high‐valent iron species. Furthermore, an unusual effect of solvent on the kinetics of oxo‐iron(IV) porphyrin π‐cation radical formation in methanol is demonstrated and discussed in the present work.
Anionic Reagents with Silicon‐Containing Double Bonds
Authors: Scheschkewitz David 
Published: February 2009

AbstractESi transfer: Anionic compounds capable of transferring a silicon‐containing double bond are reviewed (see figure), particularly reagents with SiSi moieties (Tip=2,4,6‐iPr3C6H2, M=Li, Na, K) and their applications towards main‐group and transition‐metal electrophiles, as well as their reactivity towards organic compounds. A few recently reported derivatives with SiC (Ad=1‐adamantyl) and SiP moieties are included for completeness.magnified imageAnionic compounds capable of transferring a silicon double bond are summarized following an introduction to the differences between alkenes and their heavier homologues. The main focus is on reagents with SiSi moieties and their applications towards main‐group and transition‐metal electrophiles, as well as their reactivity towards organic compounds, but a few recently reported derivatives with SiC and SiP bonds are also included.
Toward Volatile and Nonvolatile Molecular Memories: Fluorescence Switching Based on Fluoride‐Triggered Interconversion of Simple Porphyrin Derivatives
Authors: Shundo Atsuomi , Hill Jonathan P. , Ariga Katsuhiko 
Published: February 2009

AbstractWritten in the gel: A fluoride‐writable memory system has been demonstrated by using two porphyrin derivatives. Structural modification enabled both volatile and nonvolatile modes. For both porphyrins, fluorescence is quenched by addition of F−with only one of the derivatives returning to its initial fluorescent state following removal of F−(see scheme). Nonvolatile behaviour is based on anion‐induced conversion from porphyrin to oxoporphyrinogen.magnified image
An Extremely Simple Dibenzopentalene Synthesis from 2‐Bromo‐1‐ethynylbenzenes Using Nickel(0) Complexes: Construction of Its Derivatives with Various Functionalities
Authors: Kawase Takeshi , Konishi Akihito , Hirao Yasukazu , Matsumoto Kouzou , Kurata Hiroyuki , Kubo Takashi 
Published: February 2009

AbstractNice and easy: A very simple synthesis for dibenzopentalenes, which starts from 1‐bromo‐2‐ethynylbenzenes, has been developed. It uses Ni0 complexes (see scheme), from which a relatively stable NiII complex as an important intermediate has been isolated. Dibenzopentalenes with various functional groups can be prepared by the procedure, and their electronic properties are consistent with theoretical calculations.magnified imageAn extremely simple dibenzopentalene synthesis from readily available 2‐bromo‐1‐ethynylbenzenes using a nickel(0) complex is described. Although the yields are moderate, the formation of three CC bonds in a single process and the high availability of the starting materials are important advantages of this reaction. The corresponding aryl–nickel(II) complex as an important intermediate was isolated as relatively stable crystals, and the structure was confirmed by X‐ray crystallographic analysis. The high stability of this complex should play a key role in this reaction. The reaction is applicable to the preparation of dibenzopentalenes bearing various functional groups. Their electronic properties are consistent with theoretical calculations. The cyclic voltammograms of these compounds reveal highly amphoteric redox properties. In particular, the electron‐donating property of a tetramethoxy derivative is greater than that of oligothiophenes and dibenzodithiophenes and almost comparable to that of pentacene.
Synthesis of Carbosilane Dendrimers Containing up to Four Metal Layers
Authors: Angurell Inma , Rossell Oriol , Seco Miquel 
Published: February 2009

AbstractOnion structures: Carbosilane dendrimers containing up to four metal layers have been constructed (see picture). The metal layers are linked by di‐ or tritopic N,P ligands. Selective deconstruction of the dendrimers is achieved by using salts of chloride or iodide anions.magnified imageMetallodendrimers are an important class of materials with valuable properties and applications in a large number of areas. Herein, we report a highly efficient route for the synthesis of carbosilane dendrimers containing multimetal layers. The procedure involves the use of heteroditopic and tritopic P,N ligands as connectors of the metal layers. The synthetic strategy is based on the ability of the latter ligands to react selectively with the metal complexes [AuCl(tht)] (tht: tetrahydrothiophene), [{RuCl2(p‐cymene)}2] and [Pd(η3‐2‐MeC3H4)(cod)](OTf) (cod: 1,5‐cyclooctadiene; OTf: triflate). In this way, metallodendrimers containing trimetallic Ru‐Au‐Pd or tetrametallic Ru‐Au‐Au′‐Pd layers have been formed and characterized. The trimetallic dendrimer 9 can be selectively deconstructed by cleavage of the RuN or AuN bonds by reaction with chloride or iodide salts, respectively.
Highly Sensitive Magnetic Effects Induced by Hydrogen‐Bonding Interactions in a High‐Spin Metallosupramolecular Fe4II [2×2] Grid‐Type Complex
Authors: Stefankiewicz Artur R. , Lehn Jean‐Marie 
Published: February 2009

AbstractA sensitive magnetic nanoprobe: Hydrogen‐bonding interactions are reflected with great sensitivity in the 1H NMR spectra of a high‐spin multinuclear Fe4II [2×2] grid‐type complex (see scheme) and the measured shifts can be used to evaluate the hydrogen‐bond donating ability. The grid complex also represents a prototype of a very sensitive magnetic nanoreceptor for the detection of very small changes around a magnetic center.magnified image
Chemo‐ and Regioselective Palladium‐Catalyzed Oxycyclization Reactions of Allendiols: Preparation of Five‐, Six‐, and Eight‐Membered Cycles
Authors: Alcaide Benito , Almendros Pedro , Carrascosa Rocío , Martínez del Campo Teresa 
Published: February 2009

AbstractPositive discrimination: Chemo‐ and regioselective palladium‐catalyzed cycloetherification of allendiols, namely β,γ‐ and γ,δ‐allendiols, may occur by judicious choice of palladium‐catalyzed conditions owing to their potential ability to discriminate between both nucleophilic sites (see scheme).magnified image
Cover Picture: Gated and Differently Functionalized (New) Porous Capsules Direct Encapsulates' Structures: Higher and Lower Density Water (Chem. Eur. J. 8/2009)
Authors: Mitra Tamoghna , Miró Pere , Tomsa Adrian‐Raul , Merca Alice , Bögge Hartmut , Ávalos Josep Bonet , Poblet Josep Maria , Bo Carles , Müller Achim 
Published: February 2009

AbstractUbiquitous water is apart from its anomalies, for several reasons the most mysterious compound. According to its basic role in life processes it has even been considered as a biomolecule especially in context of the important role of confined “high and low density water”. C. Bo, A. Müller et al. report on page 1844 ff., confined higher and lower density water assemblies encapsulated in the same type of porous capsule that exhibit differently functionalized internal shells (see picture).magnified image
Post‐myocardial Infarction Intraventricular Conduction Defects and B‐type Natriuretic Peptide Levels
Authors: Ciuraszkiewicz Katarzyna , Janion Marianna , Sielski Janusz , Dudek Dariusz , Gawor Zenon 
Published: February 2009

AbstractBackgroundLevels of B‐type natriuretic peptide (BNP), a significant marker of left ventricular (LV) dysfunction, may provide information on the severity of heart failure in patients with intraventricular conduction defects (IVCD).The aim of this study was to measure serum BNP levels in post‐myocardial infarction (MI) patients with IVCD.MethodsIn 2004–2005 during standard follow‐up at 6 mo after acute MI in 158 subjects, BNP was measured using an immunoenzymatic method. Of them, 126 patients had IVCD: 31, left bundle branch block (LBBB); 36, right bundle branch block (RBBB); 30, left anterior hemiblock (LAH); and 29, left posterior hemiblock (LPH). Thirty two patients with a previous MI, but without IVCD, served as controls, whereas 15 healthy subjects entered the comparative group.ResultsIn post‐MI patients with IVCD, the mean BNP level was significantly higher than in their counterparts without IVCD (p < 0.001) and in healthy subjects (p < 0.001). The highest BNP level was found in patients with LBBB and RBBB. In patients with LAH and LPH, levels of BNP were insignificantly higher than in patients without IVCD.ConclusionsSignificantly higher BNP levels in patients with previous MI and IVCD suggest more severe heart failure than in their counterparts without IVCD with comparable LV ejection fraction. Copyright © 2008 Wiley Periodicals, Inc.
Glycopeptide Dendrimers with High Affinity for the Fucose‐Binding Lectin LecB from Pseudomonas aeruginosa
Authors: Kolomiets Elena , Swiderska Magdalena A. , Kadam Rameshwar U. , Johansson Emma M. V. , Jaeger Karl‐Erich , Darbre Tamis , Reymond Jean‐Louis 
Published: February 2009

AbstractDendritic antibacterial agents: Glycopeptide dendrimer biofilm inhibitors were synthesized combinatorially and optimized for binding to the fucose‐specific lectin LecB, which has high affinity of fucose. These dendritic ligands are potential antibacterial agents against Pseudomonas aeruginosa, an antibiotic resistant human pathogen.magnified imageThe fucose‐specific lectin LecB is implicated in tissue binding and biofilm formation by the opportunistic pathogen Pseudomonas aeruginosa, which causes severe respiratory tract infections mainly in immunocompromised patients or cancer patients undergoing chemotherapy. With a view to developing multivalent LecB inhibitors as novel antibacterial agents, a combinatorial library containing 15 625 tetravalent C‐fucosyl peptide dendrimers with the basic structure (CFuc‐X6X5X4)4(LysX3X2X1)2LysIleHisNH2 (CFuc=α‐L‐fucosyl acetic acid, X1–6=amino acids, Lys=lysine branching) was screened for lectin binding using on‐bead binding assays. Ten tetravalent and three octavalent dendrimers derived from the identified sequences were prepared by solid‐phase peptide synthesis (SPPS), cleaved from the resin, and purified by preparative HPLC. Relative affinities of these soluble ligands to LecB were determined by an enzyme‐linked lectin assay (ELLA). Strong binding was observed for tetravalent and octavalent ligands, with up to 440‐fold enhancement in potency over fucose for the octavalent cationic dendrimer 2G3 (CFuc‐LysPro)8(LysLeuPhe)4(LysLysIle)2LysHisIleNH2). Mono‐ and divalent controls showed affinities similar to fucose, highlighting the importance of multivalency for binding. Docking studies showed that the C‐fucosyl group of the dendrimers can adopt the same binding mode as fucose itself, with the peptide arms protruding from the binding pocket and establishing specific contacts with the lectin.