bluuebunny/crossref_metadata_2025_split huggingface dataset:
A new traffic model for backbone networks and its application to performance analysis
Authors: Yu Ming , Daut David G. 
Published: October 2007

AbstractIn this paper, we present a new traffic model constructed from a random number of shifting level processes (SLP) aggregated over time, in which the lengths of the active periods of the SLP are of Pareto or truncated Pareto distribution. For both cases, the model has been proved to be asymptotically second‐order self‐similar. However, based on extensive traffic data we collected from a backbone network, we find that the active periods of the constructing SLPs can be approximated better by a truncated Pareto distribution, instead of the Pareto distribution as assumed in existing traffic model constructions. The queueing problem of a single server fed with a traffic described by the model is equivalently converted to a problem with a traffic described by Norros' model. For the tail probability of the queue length distribution, an approximate expression and upper bound have been found in terms of large deviation estimates and are mathematically more tractable than existing results. The effectiveness of the traffic model and performance results are demonstrated by our simulations and experimental studies on a backbone network. Copyright © 2007 John Wiley & Sons, Ltd.
GAD isoforms exhibit distinct spatiotemporal expression patterns in the developing mouse lens: Correlation with Dlx2 and Dlx5
Authors: Kwakowsky Andrea , Schwirtlich Marija , Zhang Qi , Eisenstat David D. , Erdélyi Ferenc , Baranyi Mária , Katarova Zoya D. , Szabó Gábor 
Published: October 2007

AbstractGamma‐aminobutyric acid (GABA), the major inhibitory neurotransmitter of the adult nervous system and its biosynthetic enzyme glutamic acid decarboxylase (GAD) are abundantly expressed in the embryonic nervous system and are involved in the modulation of cell proliferation, migration, and differentiation. Here we describe for the first time the expression of GABA and embryonic and adult GAD isoforms in the developing mouse lens. We show that the GAD isoforms are sequentially induced with specific spatiotemporal profiles: GAD65 and embryonic GAD isoforms prevail in primary fibers, while GAD67 is the predominant GAD expressed in the postnatal secondary fibers. This pattern correlates well with the expression of Dlx2 and Dlx5, known as upstream regulators of GAD. GABA and GAD are most abundant at the tips of elongating fibers and are absent from organelle‐free cells, suggesting their involvement is primarily in shaping of the cytoskeleton during fiber elongation stages. Developmental Dynamics 236:3532–3544, 2007. © 2007 Wiley‐Liss, Inc.
Zebrafish cdc25a is expressed during early development and limiting for post‐blastoderm cell cycle progression
Authors: Nogare Damian E. Dalle , Arguello Andrea , Sazer Shelley , Lane Mary Ellen 
Published: October 2007

AbstractCdc25 phosphatases are required for eukaryotic cell cycle progression. To investigate mechanisms governing spatiotemporal dynamics of cell cycle progression during vertebrate development, we isolated two cdc25 genes from the zebrafish, Danio rerio, cdc25a, and cdc25d. We propose that Zebrafish cdc25a is the zebrafish orthologue of the tetrapod Cdc25A genes, while cdc25d is of indeterminate origin. We show that both genes have proliferation promoting activity, but that only cdc25d can complement a Schizosaccharomyces pombe loss of function cdc25 mutation. We present expression data demonstrating that cdc25d expression is very limited during early development, while cdc25a is widely expressed and consistent with the mitotic activity in previously identified mitotic domains of the post‐blastoderm zebrafish embryo. Finally, we show that cdc25a can accelerate the entry of post‐blastoderm cells into mitosis, suggesting that levels of cdc25a are rate limiting for cell cycle progression during gastrulation. Developmental Dynamics 236:3427–3435, 2007. © 2007 Wiley‐Liss, Inc.
FGFR2IIIb signaling regulates thymic epithelial differentiation
Authors: Dooley James , Erickson Matthew , Larochelle William J. , Gillard Geoffrey O. , Farr Andrew G. 
Published: October 2007

AbstractHeterogeneous epithelial populations comprising the thymic environment influence early and late stages of T‐cell development. The processes that regulate the differentiation of thymic epithelium and that are responsible for this heterogeneity are not well understood, although mesenchymal/epithelial interactions are clearly involved. Here, we show that targeted expression by thymocytes of an fibroblast growth factor receptor‐2IIIb (FGFR2IIIb) ligand, FGF10, profoundly alters the differentiation and function of thymic epithelium (TE). Reconstitution of irradiated lckFGF10 mice with normal bone marrow restores normal thymic organization and function, while wild‐type mice reconstituted with lckFGF10 bone marrow recapitulates some of the thymic alterations seen in lckFGF10 mice. We also demonstrate that interference with FGFR2IIIb signaling in the thymus with a soluble FGFR2IIIb dominant‐negative fusion protein leads to precocious reductions in thymic size and cellularity that resemble age‐related thymic involution. These findings indicate that TE compartments are dynamically maintained and that FGF signals are involved in this process. Developmental Dynamics 236:3459–3471, 2007. © 2007 Wiley‐Liss, Inc.
A Basket‐Like [Sr⊂P6MoV4MoVI14O73]10– Polyoxoanion Modified with {Cu(phen)(H2O)x} (x = 1–3) Fragments: Synthesis, Structure, Magnetic, and Electrochemical Properties
Authors: Yu Kai , Li Yang‐Guang , Zhou Bai‐Bin , Su Zhan‐Hua , Zhao Zhi‐Feng , Zhang Yu‐Nan 
Published: October 2007

AbstractHydrothermal reaction of a mixture of Na2MoO4·2H2O, H3PO4, CuCl2·2H2O, o‐phenanthroline, and SrCl2 in water leads to the isolation of a basket‐like mixed‐valent polymolybdophosphate hybrid compound, [Cu(phen)(H2O)3][{Cu(phen)(H2O)2}{Cu(phen)(H2O)}3{Sr⊂P6Mo4V Mo14VIO73}]·3H2O 1, which crystallizes in the space group P$\bar {1}$ with a = 13.778(3) Å, b = 19.267(4) Å, c = 24.168(5) Å, α = 110.64(3)°, β = 90.31(3)°, γ = 110.02(3)°, V = 5582.8(2) Å3, Z = 2. Single‐crystal X‐ray diffraction analysis shows that the four‐electron‐reduced basket‐like polyoxoanion [Sr⊂P6Mo4VMo14VIO73]10– contains a new tetravacant γ‐Dawson‐type unit and a “handle”‐shaped {P4Mo4} segment, which are highly modified with {Cu(phen)(H2O)x} (x = 1–3) fragments. Electrochemical analysis shows that 1‐modified carbon paste electrode (CPE) displays good electrocatalytic activity to reduce hydrogen peroxide. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
Coordination Alternatives in Dinuclear Bis(pyridin‐2‐ylalkyl)benzylaminecopper(II) Complexes with OH–, RO–, F–, or Cl– Bridges: Experimental Structures and DFT Preferences
Authors: Manzur Jorge , Vega Andrés , García Ana María , Acuña Carolina , Sieger Monika , Sarkar Biprajit , Niemeyer Mark , Lissner Falk , Schleid Thomas , Kaim Wolfgang 
Published: October 2007

AbstractThe compounds [L1Cu(μ‐OH)2CuL1](ClO4)2 (1), [L2Cu(μ‐OH)2CuL2](ClO4)2 (2), [L3Cu(μ‐OH)2CuL3](ClO4)2 (3), [L3Cu(μ‐OMe)2CuL3](ClO4)2 (4), [L3Cu(μ‐F)2CuL3](BF4)2 (5), [L4Cu(μ‐Cl)2CuL4](ClO4)2 (6), and [Cu(μ‐L5)2Cu](ClO4)2 (7), where L1 = bis(pyridin‐2‐ylmethyl)benzylamine, L2 = (6‐methylpyridin‐2‐ylmethyl)(pyridin‐2‐ylmethyl)benzylamine, L3 = bis(6‐methylpyridin‐2‐ylmethyl)benzylamine, L4 = (pyridin‐2‐ylethyl)(pyridin‐2‐ylmethyl)benzylamine, and L5 =(6‐oxidomethylpyridin‐2‐ylmethyl)(6‐methylpyridin‐2‐ylmethyl)benzylamine, were structurally characterized and studied by low‐temperature EPR spectroscopy. The formation of compound 5 involved fluoride abstraction from BF4– and that of 7 involved O2‐assisted C–H (methyl) activation/monooxygenation of L3. Whereas the dications of 1–4 and 7 possess a square‐pyramidal configuration at the copper(II) centers with hydroxide or alkoxide bridges in equatorial positions, the dications of 5 and 6 exhibit equatorial/axial arrangements for the bridging halide ions. In the dication of 5, the tridentate ligand binds in a meridional fashion and includes two adjacent five‐membered chelate rings. Such a situation has been observed previously only with chloride, alkoxide, or aqua bridges. In contrast to the syn configuration of the dication of 2, the dications of complexes 1, 3, 4, and 7 adopt an anti configuration with respect to the binding of Ln. The dications of 1, 2, and 7 have the pyridinyl or 6‐methylpyridinyl groups in the axial position, whereas those of 3 and 4 feature the tertiary amine N atom at that site. DFT calculations of various configurations of the dications of 1–6 reproduce the experimentally observed structural alternatives in complexes 1–4, but they do not predict the axial/equatorial structure of 5 as the lowest‐energy configuration. The systematic overestimation of repulsive forces and thus of distances by DFT may result in an underestimation of the π‐π interaction between the largely coplanar mer‐L3 ligands separated by about 3.6 Å in 5, which probably affects its structure. By incorporating these and previous results, the syn versus anti, equatorial/equatorial versus equatorial/axial, and axial pyridine versus axial amine structural alternatives are discussed.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
Synthesis of Dicarboxylate “C‐Clamp” 1,2‐Diethynylarene Compounds as Potential Transition‐Metal Ion Hosts
Authors: Reisner Erwin , Lippard Stephen J. 
Published: October 2007

AbstractWe report an efficient convergent synthesis of a new type of C‐clamp ligand with a 1,2‐diethynylarene scaffold involving a chelate host capable of binding a guest molecule in its endo‐dicarboxylate pocket. The chemistry involves a combination of palladium‐catalyzed Sonogashira, Heck, and Suzuki cross‐coupling reactions. The compounds 2,3‐bis[2‐(2′‐carboxybiphenyl‐4‐yl)ethynyl]triptycene and 4,5‐bis[2‐(2′‐carboxybiphenyl‐4‐yl)ethynyl]veratrole and their 2′‐carboxy‐m‐terphenyl‐4‐yl analogues were designed as dinucleating ligands to assemble carboxylate‐bridged transition‐metal complexes with a windmill geometry. The X‐ray crystal structure of one such C‐clamp compound containing co‐crystallized water molecules reveals strong hydrogen bonds of the aqua guest to the endo‐oriented carboxylic acid entities of the C‐clamp host. In addition, two syn‐N‐donor ligands were prepared as a synthetic scaffold to mimic the geometric arrangement of N‐donor atoms in carboxylate‐bridged dinuclear proteins. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
An Expeditious Assembly of 3,4‐Benzannulated 8‐Oxabicyclo[3.2.1]octane Systems by [2+2+2] Alkyne Cyclotrimerisation: Total Synthesis of (–)‐Bruguierol A (Eur. J. Org. Chem. 33/2007)
Authors: Ramana Chepuri V. , Salian Sumanth R. , Gonnade Rajesh G. 
Published: October 2007

AbstractThe cover picture shows the use of a [2+2+2] cyclotrimerization reaction for the construction of strained benzannulated 8‐oxabicyclo[3.2.1]octane systems. Wilkinson's catalyst was found to be successful in accomplishing this cross alkyne cyclotrimerization for oxa‐bridged bicyclic systems. The first total synthesis of (–)‐bruguierol A, that establishes its absolute configuration, was accomplished by employing this approach. Details are discussed in the Short Communication by C. V. Ramana et al. on p. 5483 ff.
Amperometric Biosensor for Hydrogen Peroxide, Using Supramolecularly Immobilized Horseradish Peroxidase on the β‐Cyclodextrin‐Coated Gold Electrode
Authors: Camacho Conrado , Matías Juan C. , Chico Belkis , Cao Roberto , Gómez Leissy , Simpson Benjamin K. , Villalonga Reynaldo 
Published: October 2007

AbstractHorseradish peroxidase, previously modified with 1‐adamantane moieties, was supramolecularly immobilized on gold electrodes coated with perthiolated β‐cyclodextrin. The functionalized electrode was employed for the construction of an amperometric biosensor device for hydrogen peroxide using 1 mM hydroquinone as electrochemical mediator. The biosensor exhibited a fast amperometric response (6 s) and a good linear response toward H2O2 concentration between 12 μM and 450 μM. The biosensor showed a sensitivity of 1.02 mA/M cm2, and a very low detection limit of 5 μM. The electrode retained 97% of its initial electrocatalytic activity after 30 days of storage at 4 0C in 50 mM sodium phosphate buffer, pH 7.0.
DNA damage and repair capacity in lymphocytes from obstructive sleep apnea patients
Authors: Kontogianni Konstantina , Messini‐Nikolaki Niki , Christou Konstantinos , Gourgoulianis Konstantinos , Tsilimigaki Smaragdi , Piperakis Stylianos M. 
Published: October 2007

AbstractObstructive sleep apnea (OSA) syndrome is a respiratory disease that is linked to heart attacks and high blood pressure. In the present study, we used the Comet assay to compare basal DNA damage and DNA damage induction by hydrogen peroxide, ethanol, and γ‐irradiation in lymphocytes from 35 OSA patients and 35 controls. We also measured the apoptosis and necrosis produced by these agents and the ability of the lymphocytes to repair the induced DNA damage. It was found that lymphocytes isolated from OSA patients had higher basal levels of DNA damage and were more sensitive to the effects of the DNA‐damaging agents than lymphocytes from controls. OSA patients also had a reduced capacity to repair the DNA damage induced by the three agents, but apoptosis and necrosis were similar in OSA patients and the controls. Environ. Mol. Mutagen., 2007. © 2007 Wiley‐Liss, Inc.
The sampling‐based dynamic procedure as tool for higher‐order discretization
Authors: Fauconnier D. , De Langhe C. , Dick E. 
Published: October 2007

AbstractAccuracy improvement is demonstrated by alternative use of a recently proposed LES formalism based on sampling operators. It is shown that the sampling‐based dynamic procedure, in combination with an appropriate truncation error model, can be used as a technique to increase the numerical accuracy of a discretization. The technique is resemblant to Richardson extrapolation. The procedure is tested on a 2D lid‐driven cavity at Re=400 using a finite difference method. Promising results are obtained. Copyright © 2007 John Wiley & Sons, Ltd.
Concurrent epithelioid malignant peripheral nerve sheath tumor and papillary thyroid carcinoma in the treated field of Hodgkin's disease
Authors: Yildirim Gokcen , Gillenwater Ann M. , Ordonez Nelson G. , Garden Adam S. , El‐Naggar Adel K. 
Published: October 2007

AbstractBackground.Simultaneous malignancies in the field of radiation for Hodgkin's disease is an extremely rare event. A unique case of concurrent thyroid and neck mass in the postirradiation field of a young patient with Hodgkin's disease is presented.Methods and Results.Thyroidectomy and excision biopsy of the neck mass were performed. A 1.5‐cm papillary thyroid carcinoma was identified in thyroidectomy and an initial diagnosis of undifferentiated malignant neoplasm was rendered on the neck mass biopsy. Subsequent surgical excision of the neck mass and immunohistochemical analysis revealed malignant peripheral nerve sheath tumor.Conclusion.Concurrent malignancies in the field of treatment of Hodgkin's disease may occur. Rare malignancies including malignant peripheral nerve sheath tumor may be encountered along with the more common papillary thyroid carcinoma. © 2007 Wiley Periodicals, Inc. Head Neck, 2008
Unequal burden of head and neck cancer in the United States
Authors: Goodwin W. Jarrard , Thomas Giovana R. , Parker Dorothy F. , Joseph Debbie , Levis Silvina , Franzmann Elizabeth , Anello Charles , Hu Jennifer J. 
Published: October 2007

AbstractBackground.Black Americans are adversely affected by many types of malignancies.Methods.We reviewed data from the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) program to evaluate racial disparities in head and neck cancer incidence, mortality, and survival.Results.Head and neck cancer incidence is greater in the black population and peaks at a younger age. The incidence disparity is decreasing over time and is less for cancers of the oral cavity/pharynx (OCP) than for cancers of the larynx. The disparity in survival after diagnosis is substantial for both sites and is increasing over time because of improvement in survival for the white population, but not for the black population. Some, but not all, of the survival disparity is due to more advanced stage at the time of diagnosis within the black population. The age‐adjusted mortality rate for black men is approximately twice the rate for white men.Conclusion.Black Americans clearly bear a greater burden from head and neck cancer. The underlying causes are largely unknown, but are most likely due to a complex interplay of differences in access to health care, quality of medical care, biologic/genetic factors, incidence of comorbid conditions, exposure to carcinogens, diet, and cultural beliefs. Prospective studies are needed to define the relative importance of these factors and to inform intervention strategies. © 2007 Wiley Periodicals, Inc. Head Neck, 2008
Medial sural artery perforator flap for tongue and floor of mouth reconstruction
Authors: Chen Shao‐Liang , Chen Tim‐Mo , Dai Niann‐Tzyy , Hsia Yi‐Jan , Lin Yaoh‐Shiang 
Published: October 2007

AbstractBackground.The radial forearm flap is frequently considered the first choice for tongue reconstruction, but the disadvantages of donor site morbidity are well known. The search for another thin skin flap as an alternative has led to the application of the medial sural artery perforator flap.Methods.We used 12 medial sural artery perforator flaps to reconstruct tongue and floor of mouth following cancer ablation. We paid attention to the major perforator (vein ≥ 1 mm) as the vascular relay.Results.Most flaps were raised with a single perforator. The size of the skin paddle varied from 9 cm × 5 cm to 14 cm × 12 cm. The mean thickness of the flap was 5.2 mm. We reexplored 1 patient for venous insufficiency and could not salvage the flap.Conclusions.The thin medial sural artery perforator flap permits high accuracy of tongue restoration and reduces the morbidity at the donor site. © 2007 Wiley Periodicals, Inc. Head Neck, 2008
Successful treatment of pulmonary metastatic salivary ductal carcinoma with trastuzumab‐based therapy
Authors: Prat Aleix , Parera Marta , Reyes Vicky , Peralta Sergio , Cedrés Susana , Andreu Jordi , Huguet Pere , del Campo Josep Maria 
Published: October 2007

AbstractBackgroundSalivary ductal carcinoma (SDC) is an uncommon malignant tumor of the salivary glands. Although there is no known standard of care for the treatment of advanced disease, the vast majority of patients with SDC may be offered palliative systemic therapy. We report a case of epidermal growth factor receptor 2 (HER2)‐positive metastatic submandibular SDC with a complete and durable clinical response to treatment with trastuzumab in combination with chemotherapy.Methods and ResultsA 62‐year‐old man was diagnosed with SDC of the left submandibular gland with extensive cervical lymph node involvement. The lesion was completely resected, and the patient underwent postoperative radiotherapy. After 6 months, multiple pulmonary metastatic lesions were detected. A complete response was reached with trastuzumab‐based combination therapy, and no evidence of disease progression has been observed after 14 months of initiation of systemic therapy.ConclusionTrastuzumab‐based combination therapies should be considered for advanced SDC. © 2007 Wiley Periodicals, Inc. Head Neck 2008
The cognitive effects of modulating the glycine site of the NMDA receptor with high‐dose glycine in healthy controls
Authors: Palmer Colin , Ellis Kathryn A. , O'Neill Barry V. , Croft Rodney J. , Leung Sumie , Oliver Chris , Wesnes Keith A. , Nathan Pradeep J. 
Published: October 2007

AbstractN‐methyl‐D‐aspartate (NMDA) receptors play an important role in learning and memory. Targeting the glycine modulatory site of the NMDA receptor has been suggested as a therapeutic strategy to improve cognition, although findings have not been convincing. We used the Cognitive Drug Research computerised assessment system to examine the effects of high‐dose glycine on a number of cognitive processes in healthy young subjects. The study was a randomised placebo controlled repeated measures design in which each subject received acute placebo or glycine (0.8 g/kg) orally, with treatment conditions separated by a 5‐day washout period. No significant effects of glycine were found on measures of working memory, declarative memory, attention or perceptual processing. These findings, together with those of previous studies, cast doubt over the ability of acute high‐dose glycine to improve cognitive function in healthy subjects and suggest that the optimum dose of glycine for improving cognition may vary between different populations, possibly due to differences in endogenous glycine levels and the functional status of NMDA receptors. Copyright © 2007 John Wiley & Sons, Ltd.
Regression method for estimating rainfall recharge at unconfined sandy aquifers with an equatorial climate
Authors: Tan Stephen Boon Kean , Shuy Eng Ban , Chua Lloyd Hock Chye 
Published: October 2007

AbstractA reliable estimate of rainfall recharge is essential for groundwater system managements. This study develops a method based on regression equations for estimating rainfall recharge at unconfined sandy aquifers with an equatorial climate. The developed method (GR‐I method) is generally efficient for estimating long‐term regional recharge, as the computational procedures could be formulated and executed easily using Microsoft's Excel spreadsheet. More importantly, its application could be extended to sand textures different from the sand texture used in developing the regression equations. To evaluate its reliability, the method was applied to estimate monthly gross recharge percentages at the Changi reclaimed land. When ignoring the effect of rainfall clusters, the GR‐I method was found to underestimate the monthly gross recharge percentages for those months with high monthly rainfall depths. By integrating the effect of rainfall clusters, the GR‐I method yields reliable estimates of monthly gross recharge percentages. By including daily potential evaporation as an additional input variable, the Extended GR‐I method was found to be not superior to the GR‐I method, implying that soil moisture availability is the major governing factor for actual soil evaporation in the highly porous sand medium, instead of atmospheric demand represented by the potential evaporation rate. Using the GR‐I method, the mean annual net recharge percentage of the study site was found to fall between 56·9 and 69·9%, which corresponds to a net recharge depth of 1073·8–1745·8 mm. Although the developed method provides a good alternative to other widely used methods, its recharge estimates still needs to be collaborated with estimates from other methods, as multiple techniques are highly recommended in any groundwater recharge estimations. Copyright © 2007 John Wiley & Sons, Ltd.