bluuebunny/crossref_metadata_2025_split huggingface dataset:
A perforation of a duodenal diverticulum in a 97-year-old patient after total gastrectomy and Roux-en-Y reconstruction: a case report
Authors: Ohno Shinya , Shinoda Tomohito , Kawahara Tatsuki , Nonomura Yusuke , Tachikawa Reo , Tawada Kakeru , Ikawa Aiko , Sano Bun 
Published: April 2024

AbstractMost duodenal diverticula (DD) are asymptomatic and rarely develop perforations. Perforation is the most serious complication of DD and often requires emergency surgery. A 97-year-old woman who had undergone total gastrectomy and Roux-en-Y reconstruction 30 years ago was referred to our department with chief complaints of abdominal pain and fever during her hospitalization after femoral neck fracture surgery in the orthopedic department. Contrast-enhanced computed tomography showed free air and residue in the abdominal cavity and right retroperitoneum, and an emergency laparotomy was performed. The abdominal cavity was mildly contaminated, and a 6-cm DD with a 1-cm perforation in the wall of the diverticulum on the contralateral side of the mesentery of the duodenum was found. Diverticulectomy and duodenal closure were performed and a drainage tube was placed. The patient experienced no complications and was transferred to the orthopedic department on postoperative day 10. Reports of perforation of DD after gastrectomy are very rare. Particular attention should be paid to perforation of DD after Billroth-II and Roux-en-Y reconstructions as they involve the formation of a duodenal stump that differs from the normal anatomy and may be highly invasive surgical procedures, depending on the degree of inflammation and fistula formation.
Improving permeability prediction via Machine Learning in a heterogeneous carbonate reservoir: application to Middle Miocene Nullipore, Ras Fanar field, Gulf of Suez, Egypt
Authors: Khalid Mostafa S. , Mansour Ahmed S. , Desouky Saad El-Din M. , Afify Walaa S. M. , Ahmed Sayed F. , Elnaggar Osama M. 
Published: April 2024

AbstractPredicting and interpolating the permeability between wells to obtain the 3D distribution is a challenging mission in reservoir simulation. The high degree of heterogeneity and diagenesis in the Nullipore carbonate reservoir provide a significant obstacle to accurate prediction. Moreover, intricate relationships between core and well logging data exist in the reservoir. This study presents a novel approach based on Machine Learning (ML) to overcome such difficulties and build a robust permeability predictive model. The main objective of this study is to develop an ML-based permeability prediction approach to predict permeability logs and populate the predicted logs to obtain the 3D permeability distribution of the reservoir. The methodology involves grouping the reservoir cored intervals into flow units (FUs), each of which has distinct petrophysical characteristics. The probability density function is used to investigate the relationships between the well logs and FUs to select high-weighted input features for reliable model prediction. Five ML algorithms, including Linear Regression (LR), Polynomial Regression (PR), Support Vector Regression (SVR), Decision Trees (DeT), and Random Forests (RF), have been implemented to integrate the core permeability with the influential well logs to predict permeability. The dataset is randomly split into training and testing sets to evaluate the performance of the developed models. The models’ hyperparameters were tuned to improve the model’s prediction performance. To predict permeability logs, two key wells containing the whole reservoir FUs are used to train the most accurate ML model, and other wells to test the performance. Results indicate that the RF model outperforms all other ML models and offers the most accurate results, where the adjusted coefficient of determination (R2adj) between the predicted permeability and core permeability is 0.87 for the training set and 0.82 for the testing set, mean absolute error and mean squared error (MSE) are 0.32 and 0.19, respectively, for both sets. It was observed that the RF model exhibits high prediction performance when it is trained on wells containing the whole reservoir FUs. This approach aids in detecting patterns between the well logs and permeability along the profile of wells and capturing the wide permeability distribution of the reservoir. Ultimately, the predicted permeability logs were populated via the Gaussian Random Function Simulation geostatistical method to build a 3D permeability distribution for the reservoir. The study outcomes will aid users of ML to make informed choices on the appropriate ML algorithms to use in carbonate reservoir characterization for more accurate permeability predictions and better decision-making with limited available data.
Targeting strategies with lipid vectors for nucleic acid supplementation therapy in Fabry disease: a systematic review
Authors: Rodríguez-Castejón Julen , Beraza-Millor Marina , Solinís María Ángeles , Rodríguez-Gascón Alicia , del Pozo-Rodríguez Ana 
Published: April 2024

AbstractFabry disease (FD) results from a lack of activity of the lysosomal enzyme α-Galactosidase A (α-Gal A), leading to the accumulation of glycosphingolipids in several different cell types. Protein supplementation by pDNA or mRNA delivery presents a promising strategy to tackle the underlying genetic defect in FD. Protein-coding nucleic acids in FD can be either delivered to the most affected sites by the disease, including heart, kidney and brain, or to specialized organs that can act as a production factory of the enzyme, such as the liver. Lipid-based systems are currently at the top of the ranking of non-viral nucleic acid delivery systems, and their versatility allows the linking to the surface of a wide range of molecules to control their biodistribution after intravenous administration. This systematic review follows the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement guidelines and provides an overview and discussion of the targeting ligands that have been employed so far to actively vectorize intravenously administered non-viral vectors based on lipid carriers to clinically relevant organs in the treatment of FD, for protein-coding nucleic acid (pDNA and mRNA) supplementation. Among the thirty-two studies included, the majority focus on targeting the liver and brain. The targeting of the heart has been reported to a lesser degree, whereas no articles addressing kidney-targeting have been recorded. Although a great effort has been made to develop organ-specific nucleic acid delivery systems, the design of active-targeted carriers with high quality, good clinical translation, and large-scale manufacturing capacity is still challenging.
Graphical Abstract
Leveraging Digital Media to Promote Youth Mental Health: Flipping the Script on Social Media-Related Risk
Authors: Hamilton Jessica L. , Torous John , Szlyk Hannah S. , Biernesser Candice , Kruzan Kaylee P. , Jensen Michaeline , Reyes-Portillo Jazmin , Primack Brian A. , Zelazny Jamie , Weigle Paul 
Published: April 2024

Abstract
Purpose of Review
Despite growing public concern about the negative impact of digital media for mental health problems, there are key ways in which digital media can be leveraged to prevent such outcomes. This article reviews research exploring the ways that digital media, particularly social media, can be used to prevent negative mental health outcomes and promote youth mental health and well-being.

Recent findings
Research indicates that media can be protective against mental health problems and promote mental health by enabling social support and destigmatizing mental illness, especially for youth with limited resources. Media also can be leveraged to identify those at risk, to educate, provide resources, and promote well-being, and to track symptoms and intervene to prevent or mitigate negative mental health outcomes. There is limited research on interventions designed to reduce the negative effects of digital media on mental health, especially those that harness media itself, a critical area of future research.

Summary
This article provides a summary of the current evidence on this topic, highlights key directions for future research, and provides evidence-based recommendations for adolescents, families, educators, clinicians, industry, and policy-makers to prevent mental health problems related to media.
What shall I do? Similarities and differences in moral judgements between Austrian and Mongolian students
Authors: Bart Victoria K. E. , Sharavdorj Erdenechimeg , Boldbaatar Enerel , Munkhnasan Delgerjav , Rieger Martina 
Published: April 2024

AbstractCross-cultural research in moral judgements (e.g., whether to sacrifice one person to save several others) often focuses on differences regarding the instrumentality of harm, i.e., whether the death of one person is an instrument to save several others (instrumental) or is an incidental side-effect (incidental). Less cross-cultural research exists on differences regarding one’s own involvement, i.e., whether one’s own life or only the life of others is at risk. The present study investigated the influence of both factors on moral judgements in a European (Austrian) and an Asian (Mongolian) culture. Austrians and Mongolians read moral dilemmas and chose whether (or not) they would carry out an action that sacrifices one but saves several others. Afterwards, they rated the moral acceptability of that action. Both cultures chose utilitarian actions (sacrificing one to save others) less often in instrumental than in incidental dilemmas. Thus, instrumental harm is universally regarded as worse than incidental harm. In instrumental dilemmas, Mongolians chose more utilitarian actions than Austrians, indicating that Mongolians more likely act in favour of group welfare. In instrumental dilemmas, Austrians chose more utilitarian actions when their own life was at risk than when only the life of others was at risk. In incidental dilemmas, the opposite was observed for Mongolians. Thus, Austrians more likely act in favour of self-interest, whereas Mongolians perceive it as more unvirtuous to harm others to save oneself. Results on moral acceptability ratings and decision times further support those cultural differences. Thus, culture may convey certain moral decisions.
Filling the void: boredom’s associations with hoarding symptom severity
Authors: Weiss Emily R. , Todman McWelling , Roane David M. 
Published: April 2024

AbstractIn hoarding disorder, features including attentional difficulties and emotion dysregulation can contribute to the core symptoms of clutter, difficulties discarding, and excessive acquisition. Boredom is a negative feeling state that shares a high level of overlap with associated features of hoarding, including inattention, depressive symptoms, and impulsivity, and has been implicated in compulsive buying behaviors. Boredom may be a particularly relevant factor in compulsive hoarding; however, this relationship remains significantly under-researched. The present studies aimed to thoroughly investigate associations between boredom and hoarding severity using diverse methodologies. Study 1 (N = 253) replicated, in an online community sample, previously reported positive associations between hoarding severity and recent state boredom while statistically controlling for potentially confounding variables (e.g., depression, indecisiveness), and extended these findings to include boredom proneness. In Study 2, individuals with elevated hoarding symptoms (n = 56) and a history of hoarding problems (n = 43) reported higher levels of recent state and trait boredom than controls (n = 61). Additionally, boredom was associated with performance on simulated acquiring and discarding tasks. Finally, Studies 3a (N = 144) and 3b (N = 146) attempted the first experimental tests of induced boredom on acquiring and discarding behaviors. Although results were mixed and preclude causal conclusions, exploratory analyses revealed that individuals reporting higher in-the-moment boredom took more (p = .008) and discarded fewer (p = .021) items on the simulated tasks. Overall, results suggest that boredom may have crucial implications in hoarding symptom severity.
The recent research progress in neurobiological characteristics and pain regulation of the cerebrospinal fluid-contacting nucleus
Authors: Wei Jingqiu , Liu He , Zhou Fang , Lu Xianfu , Zhang Hongxing , Zhang Licai 
Published: April 2024

AbstractThe ependymal epithelium forms the cerebrospinal fluid barrier, separating the brain and spinal cord from the cerebrospinal fluid. However, in specific regions of the central nervous system, there are neurons that directly interface with the cerebrospinal fluid, including neuronal bodies, dendrites, or axons, This constitutes what is referred to as the "cerebrospinal fluid contacting neurons system (CSF-CNS)". The research team led by Professor Zhang has successfully utilized cholera toxin subunit B coupled horseradish peroxidase complex (CB-HRP) to selectively label the specialized neuron system that interfaces with cerebrospinal fluid, pioneeringly designating it as the "cerebrospinal fluid-contacting nucleus", commonly referred to as the "CSF-contacting nucleus". For the first time, the discovery of the CSF-contacting nucleus provides compelling morphological evidence for the existence of a distinct neural structure within the brain parenchyma that establishes a connection with the cerebrospinal fluid, thereby suggesting its potential significance in facilitating material and information exchange between the brain parenchyma and cerebrospinal fluid. After conducting a comprehensive series of studies on the morphological structure, material expression, gene analysis and functional aspects of the CSF-contacting nucleus in rodents and non-human primates, it has been revealed that there are fibrous connections between the CSF-contacting nucleus and the cerebral cortex and subcortical nuclei being involved in the regulatory mechanisms of pain, cognition, learning and memory, emotion, addiction, stress and anxiety responses, visceral activity, olfaction, vision processing and perception, auditory processing, perception, motor control and coordination, homeostasis regulation including maintenance of body energy and fluid balance, as well as the control of sleep–wake cycles and synchronization of biological rhythms. Current experiments have confirmed that the CSF-contacting nucleus is related to pain, morphine dependence and withdrawal, learning and memory, as well as stress. This present article offers a comprehensive review of the neurobiological characteristics and recent advancements in pain regulation of the CSF-contacting nucleus. The aim is to provide novel insights into the investigation of pain regulation within bidirectional regulatory pathway between the brain and cerebrospinal fluid, with a specific focus on elucidating the role of the CSF-contacting nucleus as a bridge structure. Additionally, the objective of this research is to propose innovative strategies for pain management and associated disorders in the future.
Land Ownership Security, Farm Investment, and Investment Risk in Indian Agriculture: Evidence from Nationally Representative Survey
Authors: Akber Nusrat , Paltasingh Kirtti Ranjan , Mishra Ashok K. , Goyari Phanindra 
Published: April 2024

AbstractThis paper examines the impact of land ownership on farm-level investment and investment risk (variability) in Indian agriculture using nationally representative survey data. The study adopts a flexible moment approach with White’s heteroscedasticity consistent standard error method. Results reveal that land ownership intensity significantly augments on-farm investment and reduces its variability. Other variables like family head’s education, access to irrigation, technical advice, credit and nonfarm income have significant inducement effects on-farm investment. We also observe that farmers’ education, age, irrigation, technical advice, MSP awareness and commercialization reduce farm investment risk. Findings have important policy implications for Indian land tenancy
FEM-based eigenstructure recovery of a space truss with active members
Authors: Boni L. , Mengali G. , Quarta A.A. , Bassetto M. 
Published: April 2024

AbstractLarge truss structures have many potential applications in space, such as antennas, telescopes and space solar power plants. In this scenario, a natural concern is the susceptibility of these lightweight structures to be damaged during their operational life, due to impacts, transient thermal states and fatigue phenomena. The inclusion of active elements, equipped with sensor/actuator systems capable of modulating their shape and strength, makes it possible to transform the truss into a smart structure capable of remedying the damage, once it is detected. In this paper, a procedure is described that is capable of restoring at least the basic functionality of a composite truss for space applications, starting with the observation that damage has occurred, regardless of its specific location. The system eigenstructure is used as a benchmark for damage detection, as well as a target characteristic for the subsequent restoration activity. The observer/Kalman filter identification algorithm (OKID), in cascade with the eigensystem realization algorithm (ERA), is adopted to reconstruct, from sensor recordings, the dynamic response of the truss in terms of system state-space representation and eigen-characteristics. Finally, a static output feedback control is developed to recover the low-frequency dynamic behaviour of the truss. The entire procedure is tested using finite element analysis. All activities are coordinated in an innovative procedure that, within a unique Python language code, automatically generates finite element (FE) models, launches finite element analysis (FEA), extracts output data, implements OKID-ERA, processes the control law and applies it to the final FE simulation.
Early-life contact with non-maternal adult cows and a pasture-based rearing environment influence behavioural responses of dairy heifers to novelty
Authors: Field Laura , Hemsworth Lauren , Jongman Ellen , McGill David , Verdon Megan 
Published: April 2024

Abstract
The complexity experienced in early life can affect trait development of individuals, including sociability and fearfulness. The modern dairy calf’s rearing environment often lacks environmental and social complexity. This study examined the effects of early-life, non-maternal adult contact and access to a physically complex environment on the responses of dairy heifers to several stressors, including restraint, social isolation, and novelty at 18 months of age. From the age of 2–13 weeks, 60 dairy heifers (Bos taurus) were reared according to one of three treatments applied to 20 calves each: (1) Hand-reared at pasture in groups of ten, with three unrelated dry cows (+S); (2) Hand-reared at pasture in groups of ten (–S); or (3) Hand-reared in sheds in groups of 10–12 as a commercial control (CC). At 13 weeks, all treatment groups were mixed and managed at pasture as a single herd. At 18 months, the responses of 50 heifers to restraint in a crush, social isolation and a novel object were observed (+S = 16, –S = 17, CC = 17). Treatment did not influence responses to restraint or social isolation, but influenced some indicators of fearfulness during exposure to a novel object. Six +S heifers interacted with the novel object compared to 0 –S and one CC, and CC heifers spent around 50% more time in vigilance than +S or –S heifers. Dairy heifers provided with early-life social enrichment in the form of non-maternal adult contact may have reduced fear of novelty. The implications for lifelong ability to adapt to novel situations, such as entry into the milking herd, should be assessed.
Religiosity and gender bias structure social networks
Authors: Ge Erhao , DongZhi CaiRang , Mace Ruth 
Published: April 2024

Abstract
The number of studies examining gender differences in the social relationship rewards associated with costly religious practice has been surprisingly low. Here, we use data from 289 residents of an agricultural Tibetan village to assess whether individuals are more inclined to establish supportive relationships with religious individuals in general and to investigate the gender disparities in the relationship between religiosity and personal network characteristics. Our results reveal that participation in religious rituals contributes to the overall development of social support networks. The benefits to personal networks, however, seem to be contingent upon gender. For resource-intensive, infrequent religious rituals such as distant pilgrimages, males seem to benefit slightly more in terms of elevated in-degree values in their personal networks, despite similar levels of investment as females. In contrast, for daily, low-cost religious practices requiring ongoing participation, both genders obtain similar increases in in-degree values through regular engagement. It becomes more challenging for women to increase their status in communities when the effort invested in religious rituals yields smaller rewards compared with the same effort by men, contributing to ongoing gender inequality. These findings highlight the importance of examining the particular characteristics of religious rituals and the gender disparities in the associated rewards.
Generic Beauville’s Conjecture
Authors: Coskun Izzet , Larson Eric , Vogt Isabel 
Published: April 2024

Abstract
Let

$\alpha \colon X \to Y$

be a finite cover of smooth curves. Beauville conjectured that the pushforward of a general vector bundle under

$\alpha $

is semistable if the genus of Y is at least

$1$

and stable if the genus of Y is at least

$2$

. We prove this conjecture if the map

$\alpha $

is general in any component of the Hurwitz space of covers of an arbitrary smooth curve Y.
A remark on Gibbs measures with log-correlated Gaussian fields
Authors: Oh Tadahiro , Seong Kihoon , Tolomeo Leonardo 
Published: April 2024

AbstractWe study Gibbs measures with log-correlated base Gaussian fields on thed-dimensional torus. In the defocusing case, the construction of such Gibbs measures follows from Nelson’s argument. In this paper, we consider the focusing case with a quartic interaction. Using the variational formulation, we prove nonnormalizability of the Gibbs measure. When$d = 2$, our argument provides an alternative proof of the nonnormalizability result for the focusing$\Phi ^4_2$-measure by Brydges and Slade (1996). Furthermore, we provide a precise rate of divergence, where the constant is characterized by the optimal constant for a certain Bernstein’s inequality on$\mathbb R^d$. We also go over the construction of the focusing Gibbs measure with a cubic interaction. In the appendices, we present (a) nonnormalizability of the Gibbs measure for the two-dimensional Zakharov system and (b) the construction of focusing quartic Gibbs measures with smoother base Gaussian measures, showing a critical nature of the log-correlated Gibbs measure with a focusing quartic interaction.