bluuebunny/crossref_metadata_2025_split huggingface dataset:
SYSTEMATIC REVIEW: TRENDS SOCIOSCIENTIFIC ISSUES IN CLIMATE CHANGE MATERIALS
Authors: Arjaya Ida Bagus Ari , Surata Sang Putu Kaler 
Published: March 2024

Socioscientific issues (SSI) merupakan isu pendidikan kontemporer yang yang menjadi bagi bekal siswa di dalam kehidupan bermasyarakat. Tujuan dari Systematic Literature Review (SLR) ini adalah untuk menganalisis a) Teori SSI yang paling relevan dipergunakan pada materi perubahan iklim , b) Metodologi yang paling relevan dipergunakan pada SSI dengan materi perubahan Iklim. Dan c) Kesimpulan serta sugesti untuk arah penelitian SSI berbasis materi perubahan iklim. Penelitian SLR ini menggunakan protokol PRISMA (Preffered Reporting Item for Systematic Review and Meta-Analysis) dengan search engine website Wiley, DOAJ, dan Springer. Dari 419 data based artikel hasil penelusuran dalam interval waktu 2017-2021 diperoleh 8 artikel yang sesuai dengan kriteria pencarian. Hasil penelitian menunjukkan bahwa teori SSI yang paling banyak dipergunakan di dalam penelitian yang terkait dengan materi perubahan iklim adalah teori (Herman et al., 2018), Sedangkan metodologi yang paling relevan dipergunakan dalam penelitian adalah metode kuantitative, mixed methods, dan kualitatif. Hasil sintesis dari kesimpulan dan saran Systematic Review mengarah kepada SSI dalam sebagai place-based instruction mampu mengembangkan berbagai jenis kompetensi siswa diluar kompetensi pedagogisnya, sehingga rekomendasi penelitian selanjutnya lebih berfokus pada pengembangan profesionalisme guru, kemampuan metakognitif siswa, dan merancang pembelajaran agar menerapkan pemahaman siswa tentang SSI serta Nature of Science (NOS).
L’antibiogramme : interprétation, pièges et nouveautés
Authors: Barnier Jean-Philippe , Lebeaux David 
Published: March 2024

L’évolution rapide de la résistance aux antibiotiques, en particulier chez les bactéries à Gram négatif, nécessite des outils fiables pour guider l’antibiothérapie. La détermination de la sensibilité aux antibiotiques est donc une activité centrale des laboratoires de microbiologie clinique. Le but est d’assurer l’adéquation entre le traitement antibiotique et la sensibilité des isolats bactériens, de détecter les résistances acquises, et de fournir des données pour le suivi de l’épidémiologie de la résistance aux antimicrobiens. De nombreuses méthodes d’antibiogramme sont disponibles : microdilution en milieu liquide, méthode automatisées, diffusion en milieu gélosé. Toutes ces techniques offrent des résultats qualitatifs : catégorisation des isolats bactériens en sensible, intermédiaire ou résistant et certaines des résultats quantitatifs (concentration minimale inhibitrice). De plus, l’antibiogramme est un outil essentiel pour la détection de mécanismes de résistance émergents, malgré les progrès de la génomique. Si de nombreux outils permettant la détection rapide des mécanismes de résistance sont aujourd’hui disponibles, il est probable que l’antibiogramme gardera une place importante dans la prise en charge des infections bactériennes dans les prochaines années. Son interprétation, parfois complexe, impose un dialogue entre le microbiologiste et le clinicien.
Discovering Differences in Consciousness of Facial Features Among Japanese University Students in the Year of Admission According to COVID-19
Authors: Komiya Nozomi 
Published: March 2024

Purpose of the study: This study aims to determine the significant differences in students' awareness of appearance between those admitted to universities during the COVID-19 pandemic and those admitted when the pandemic was deemed controlled in Japan.
Methodology: The author hypothesized notable variations in the change of self-consciousness regarding appearance, particularly facial appearance, contingent upon the year of admission. To test this hypothesis, a questionnaire survey was conducted among 428 students in Japan attending universities as of Fiscal Year 2023 to gauge their facial self-consciousness.
Main Findings: The initial analysis focused on changes in body image and facial self-consciousness. However, due to the predominant focus on facial aspects, a chi-squared test was allowed to determine the relationship between the year of admission and changes in facial self-consciousness. The results indicated a significant difference between the admission year and changes in facial self-consciousness, with the largest difference between 2020 and 2023.
Novelty/Originality of this study: The author used Cross-tabulation and Chi-Square analyses to compare previous years with 2023. The findings showed significant differences in facial self-consciousness depending on the admission year, with a p-value of less than 0.05. The results indicated statistically significant differences in facial self-consciousness among students admitted in 2020. (p < .05, =.005, =.014, ­­ =.016).
Young Learner L2 Vocabulary Acquisition: Does the Revised Hierarchical Model Apply to Child Learners?
Authors:   Akita International University, Williams Clay , Naganuma Naeko ,   Akita International University
Published: March 2024

Vocabulary learning is a process requiring the connection of mental concepts to new word-labels. The Revised Hierarchical Model claims that beginning learners recognize the meaning of L2 words via a process of translation, needing considerable time and effort to forge direct connections between L2 words and mental concepts. However, might young children, as they are still rapidly acquiring L1 vocabulary, be able to bypass the L2-to-L1 translation required by adult L2 learners, and instead link new L2 words directly to pre-existing mental concepts? This study tested over 1,000 4th-6th graders in Japanese elementary schools on their ability to match newly learned L2 words with corresponding pictures or L1 translations. The results demonstrate that students connect L2 vocabulary to pictures more quickly, and this effect becomes more robust when students are taught via pictures, which suggests that young learners are indeed capable of accessing concepts without translating from their L1. 語彙学習とは学習者の脳内に存在する概念を新しい語彙に連結するという過程である。改訂階層モデルによると、初級者は翻訳という過程を経ることで第二言語(L2)での意味を認識する。そのため、L2語彙と脳内概念への直接連結するにはかなりの時間と努力を要する。しかし、まだ急速に第一言語(L1)語彙習得過程にある子どもたちはどうだろうか。成人学習者が必要とするL2からL1への翻訳を介さずに、脳内概念とL2語彙へ直接連結することが可能なのではないだろうか。本研究では四年生から六年生の日本人小学生千人以上を対象に、新出L2語彙を対応する絵または日本語へ照合する能力について検証した。結果として、L2語彙に対応する日本語への照合よりもイメージへの照合がより早く行われ、またこの効果が絵を用いて教わった場合により強く見られた。このことから、年齢が低い学習者はL1への翻訳することなしに脳内に存在する概念にアクセス可能であることが示唆できる。
Students' Perceptions Of Geography Education In Middle And High Schools: The Importance Of Geography Education In The Education Curriculum, Dagana Dzongkhag, Bhutan
Authors: Pokhrel Leela Balab , Chhetri Ramesh Kumar 
Published: March 2024

A positive perception of the geography subject is crucial for students' academic success and their interest in learning. The identification of students’ perceptions of subjects has been carried out in many educational curricula. However, it is rarely studied in Bhutan. This study explores the students’ performance in middle and higher secondary school and their academic performance in Dagana Dzongkhag (district). To study the students’ perceptions of learning geography, the data were collected from key stages IV and V students using a convergent parallel mixed-methods design from four schools. A total of 282 students, comprising 181 from key stage IV and 101 from key stage V were selected from two middle secondary and two higher secondary schools. The quantitative data were obtained using a survey questionnaire, and the qualitative data were collected from four FGDs (focus group discussions). The findings revealed that the students have positive perceptions of learning geography, irrespective of their stages. There is a significant difference in students’ perception of learning geography between key stages IV and V. The students of key stage V have a comparatively positive perception compared to those in key stage IV. It is evident from this study that students’ perceptions towards the subject would also impact their academic performance. Therefore, to address the research findings, this study recommends the district education office and school management to prioritize geography education and establish proper mechanism to support it through relevant authorities. The study has also opened the way forward for future researchers to explore similar research with a larger population.
Efficacy of intraovarian autologous platelet-rich plasma administration in women with low ovarian reserve: A systematic review and meta-analysis
Authors: Sa’diah Yasmin Sabina , Dewanto Agung , Chandra Lukman A 
Published: March 2024

Objective:
To conduct a systematic examination and meta-analysis of the most reliable data from experimental studies evaluating the efficacy of autologous platelet-rich plasma (PRP) on low ovarian reserve.

Methods:
A comprehensive search was performed utilizing pertinent search terms across electronic databases, including PubMed, Cochrane, and Google Scholar. We included studies that assigned infertile women with low ovarian reserve in experimental studies. Ovarian reserve parameters were measured before and after PRP injection into ovaries. The data of each study was retrieved and subsequently compiled.

Results:
Of 301 articles collected and reviewed, six studies were finally included in the meta-analysis. Following PRP injection, infertile women showed a non-significant increase in anti-Mullerian hormone (AMH) level (MD=0.10; 95% CI -0.04, 0.23), a significant increase in antral follicular count (AFC) (MD=1.88; 95% CI 0.47, 3.29), and a non-significant reduction in follicle-stimulating hormone (FSH) level (MD=-0.22; 95% CI -8.32, 7.87).

Conclusions:
Autologous PRP may increase AFC, but not AMH. Although it is found beneficial in enhancing ovarian reserve (AFC), further research with strong evidence is still required.
Effect of herbal mouthwashes from Nimba (Azardirachta indica A. Juss) and curry leaves (Murraya Koenigii (L.) Spreng.) on dental plaque, Streptococcus mutans count, and gingival health in school-going children: An open-label, randomized trial
Authors: Yadav Madhukar , Gupta Sonal , Panwar Mahima 
Published: March 2024

Abstract

Background:
Herbal drugs have been used since ancient times; oral rinse of Nimba (Azardirachta indica A. Juss, locally known as the Neem) and curry leaves (Murraya Koenigii (L.) Spreng., locally known as the Meethi Neem) is one of them for maintaining better oral hygiene.

Aim:
The study aimed at determining the effect of indigenously prepared two herbal and 0.2% chlorhexidine (control group) mouthwashes on dental plaque, Streptococcus mutans count and gingival health in school-going children.

Material and methods:
Trial design was parallel with an allocation ratio of 1:1:1. Total 120 included children aged 8–14 years were randomized into three groups, namely, Neem leaves (n = 40), curry leaves (n = 40), and chlorhexidine (CHX) mouthwash (n = 40) group. At the baseline examination, plaque and gingival scores were recorded and plaque samples were taken for S. mutans count estimation. The data were entered into Microsoft Excel and analysis was performed using statistical software “SPSS-22.” Descriptive statistics and analysis of variance were applied for evaluation. Tukey’s post hoc test was used to evaluate the difference between the pairs of mouthwashes.

Results:
Statistically significant differences were found between CHX and Neem and curry leaves in plaque index, S. mutans count, and gingival index at 14 and 21 days from baseline. Neem and curry leaves were equally effective as CHX.

Conclusion:
Neem and curry leaves mouthwashes are equally effective as antiplaque and anti-gingivitis agents as that of CHX mouthwash.
Efficacy and safety of Naga Bhasma and Nisha-Amalaki Churna in the management of Madhumeha (type 2 diabetes) - A double-blind, randomized, controlled clinical trial
Authors: Krushnakumar Taviad , Sarika Makwana , Prashant Bedarkar , Patgiri BJ 
Published: March 2024

AbstractBackground:Increasing global incidence of diabetes is a serious issue and large number of researches are undergoing to find promising cure of this chronic disease. Many Ayurveda drugs have been evaluated for anti-diabetic properties; however, researches on metallic/mineral based drugs are very few. The present study aimed to assess the comparative efficacy and safety ofShashti Puta Naga Bhasma(SNB) -Trimshati Puta Naga Bhasma(TNB) withNisha-Amalaki Churna(NAC), NAC and metformin in the management of type 2 diabetes.Materials and methods:In this prospective, randomized, double blind, active controlled study; 132 patients with type 2 diabetes were included and randomly divided into four groups. Patients were treated with NAC (125 mg) with placebo (roastedSooji;course powder of wheat flour), SNB (62.5 mg) with NAC (125 mg), TNB (62.5 mg) with NAC (125 mg) twice daily before food with honey while patients in last group were continued with their ongoing Tablet Metformin 500 mg prescribed by physician as standard control without any other additional intervention for 90 days. The assessment of changes observed in blood glucose, glycosylated hemoglobin, lipid profile, hemogram, hepatic, renal profile, and clinical symptoms was carried out.Results:After 90 days of medication, fasting and postprandial blood glucose levels and clinical symptoms in three groups were significantly decreased when compared with baseline except NAC group. Hemogram and hepatic and renal profiles (safety parameters) in the four groups were not significantly different from the baseline. No adverse events were reported with the use of the studied medicine.Conclusion:SNB along with NAC possessed more symptomatic relief in comparison to TNB with NAC, NAC alone and Metformin thereby improving the quality of life of patients along with significant glycemic control and free from any significant side effects.
Microbiological indices of unregulated herbal drinks in Benin City, Nigeria: A potential health hazard to consumers
Authors: Omoruyi Zainab , Okundaye Moses Ikpomwonsa , Egunjobi Tunde Oluwasegun 
Published: March 2024

Abstract

Background:
The use of herbal medicine has increased globally due to people’s dissatisfaction with conventional medicine, family traditions, poverty, and prior positive experiences. Since the last decade, the general public has become increasingly interested in herbal products from several medicinal plants. This study sought to evaluate the microbial contamination of liquid herbal drinks sold in Benin City, Nigeria.

Materials and Methods:
Fifty different herbal medicines were purchased from three different locations in the study area. The 50 herbal medicines were centrifuged and the sediment was used for culture, biochemical, and antibiotic tests for the identification of isolated microorganisms and the assessment of the total viable bacterial count.

Results:
In comparison to regulated herbal preparations (4%), a percentage (36%) of unregulated herbal preparations contained viable bacteria. The most common bacterium found in unlicensed herbal medicines was Klebsiella pneumonia (10%). The percentage of regulated and unregulated herbal preparations that had microbiological contamination that was above the permissible limit (>10 colony-forming unit/ml) was 2% and 26%, respectively.

Conclusions:
Numerous unlicensed herbal treatments in Benin City have microbial contamination over the World Health Organization-permitted limit for aerobic and coliform bacteria. The regulatory bodies should step up their efforts to make sure that all herbal medicines marketed in the nation are legally registered and created in compliance with current Good Manufacturing Practice standards.
Cone-beam computed tomography (CBCT) dose optimization technique and image quality assessment scoring
Authors: Trivedi Gaurav , Singh Pushpendra P. , Oinam Arun S. , Singh Ranjit 
Published: March 2024

Introduction:
Linear accelerator (LINAC) embedded with kV source–imager system is capable to do image-guided radiotherapy. The only disadvantage of cone-beam computed tomography image acquisition during treatment is the extra radiation dose to the patient. The aim of this study is to optimize the CBCT imaging doses likely to be received by the patient undergoing radiotherapy without affecting image quality.

Material and Methods:
The imaging dose to the patient was estimated on CTDI phantoms. The effect of additional filters of different materials (copper, brass, aluminum of thickness 0.1 mm each) was evaluated to find the optimized dose imaging technique. For the pelvis, a single imaging protocol available on the machine was used, whereas for the head and neck region, two protocols, high-quality head and standard-dose head were used. The image quality was assessed on CATPHAN-504 phantom using Owl CATPHAN® QA online tool. A new term “Image Assessment score” (IAS) was introduced to evaluate the image quality.

Result:
In the pelvis protocol, CBCT imaging doses with an additional 0.1-mm brass, copper, and aluminum filter were measured to be reduced by 7.1%, 4.7%, and 2.5%, respectively, whereas for high-quality head protocol, the dose reduction was 25.4% (with brass filter), 22% (with copper filter), and 3.1% (with aluminum filter). For the standard-dose head protocol, doses were reduced by 7.5%, 2.8%, and 2.1% with additional 0.1-mm brass copper and aluminum filters, respectively. Acceptable image quality was observed with all the filters.

Conclusion:
Although the reconstructed images were found somewhat noisier, they did not affect the purpose of imaging, that is, treatment position verification. It was observed that these extra filters further reduce the imaging dose without much affecting the image quality.
PD-L1 expression in head and neck squamous cell carcinoma and its clinical significance: A prospective observational study from a tertiary care centre
Authors: Kilaru Sindhu , Panda Soumya Surath , Moharana Lalatendu , Mohapatra Debahuti , Mohapatra Satya Sundar G. , Panda Adyakinkar , Kolluri Spoorthy , Devaraj Suma , Kabi Ananya , Das Bharat , Biswas Ghanashyam 
Published: March 2024

Background:
Programmed Death Ligand 1 (PD-L1) expression in tumor cells contribute to tumor immunity and therapies directed against it, have shown encouraging results in recent years. As there is limited data on the significance of PD-L1 expression in Head and Neck Squamous Cell Carcinoma (HNSCC) from India, we aimed to study the PD-L1 expression and its relation with different clinic-pathological parameters in patients of HNSCC from a tertiary care center in Eastern India.

Methods:
A prospective evaluation of HNSCC patients diagnosed and managed at our center over a period of two and half years, was performed. PD-L1 expression in formalin fixed-paraffin embedded tumor tissue specimens was measured using SP-263 (Ventana) and 22C3 (Dako). A PD-L1 expression of <1%, 1–19%, ≥20% were considered negative, low, and high expression, respectively, and was correlated with various parameters.

Results:
A total of 71 patients (mean age 50.8 ± 13.3 years, 86% males) were diagnosed with HNSCC (buccal mucosa-28, tongue-22, rest of oral cavity-8, larynx-7, nasopharynx-6). The tumor was poorly differentiated in 12 (17%). PD-L1 positivity was seen in a total of 51 (71.8%) patients (1–19%:18, ≥20%:33). Thirty (85.7%) patients among those aged <50 years and 58.3% of those aged ≥50 years showed PD-L1 positivity which was significant (P = 0.01). There were no statistically significant differences in PD-L1 positivity with respect to gender, tobacco use, tumor grade as well as tumor and nodal stage. Median follow up duration was 18 months (range 3–31 months) and there was significant difference in overall survival among PD-L1 positive and negative groups (31 vs 24 months; log rank P = 0.03).

Conclusions:
72% of HNSCC patients in our cohort showed PD-L1 positivity and it was not associated with any patient demographic characteristics or aggressive pathological features. Positive PD-L1 expression may have a beneficial effect on overall survival in HNSCC.
Histologic grading of salivary gland mucoepidermoid carcinoma: A comparison of four grading systems and correlation with survival
Authors: Sood Neelam , Meena Swati , Gupta Ruchika , Gupta Sanjay 
Published: March 2024

Background:
Mucoepidermoid carcinoma (MEC) is the most common malignant lesion of salivary glands. A number of histologic grading systems are in use for MEC with variable agreement between them.

Methods:
This study was aimed at comparison of four grading systems for MEC: two qualitative (modified Healy and MSKCC grading) and two quantitative (AFIP and Brandwein grading). A retrospective search for diagnosed cases of MEC over eight years yielded 11 cases with adequate clinical details and histologic slides available for review. All cases were reviewed and graded as per the four grading systems. An inter-system agreement was assessed, and Kaplan–Meier analysis was performed to correlate the grading with clinical outcomes.

Results:
A general agreement between all four grading systems was seen in 72.7% of cases. Brandwein grading assigned the highest percentage of high grades (18.2%), whereas Memorial Sloan-Kettering Cancer Center (MSKCC) assigned the highest percentage of low-grade MEC (72.7%). The agreement between MSKCC and modified Healy was highest at 90% of cases. There was generally a poor agreement between MSKCC and Brandwein grading systems. The MSKCC grading system showed a significant correlation with disease-free survival in MEC patients.

Conclusion:
Hence, the MSKCC grading system might serve as a better histologic grading system with a predictive value for the biologic behavior of the tumor. Further larger studies are required to validate these findings and implement the uniform use of MSKCC grading for MEC of salivary glands.
Study of a plastic scintillating plate-based quality assurance system for pencil beam scanning proton beams
Authors: Seo Jaehyeon , Chung Kwangzoo , Han Youngyih , Jeong Seonghoon , Jo Yunhui , Oh Geon , Gi Yongha , Sung Heehun , Ahn Sung Hwan , Yoon Myonggeun 
Published: March 2024

Introduction:
The purpose of this study was to evaluate a plastic scintillating plate-based beam monitoring system to perform quality assurance (QA) measurements in pencil beam scanning proton beam.

Methods:
Single spots and scanned fields were measured with the high-resolution dosimetry system, consisting of a plastic scintillation plate coupled to a camera in a dark box at the isocenter. The measurements were taken at 110–190 MeV beam energies with 30° gantry angle intervals at each energy. Spot positions were determined using the plastic scintillating plate-based dosimetry system at the isocenter for 70–230 MeV beam energies with 30° gantry angle intervals. The effect of gantry angle on dose distribution was also assessed by determining the scanning pattern for daily QA and 25 fields treated with intensity-modulated proton therapy.

Results:
Spot size, field flatness, and field symmetry of plastic scintillating plate-based dosimetry system were consistent with EBT3 at all investigated energies and angles. In all investigated energies and angles, the spot size measured was ±10% of the average size of each energy, the spot position measured was within ±2 mm, field flatness was within ±2%, and field symmetry was within ±1%. The mean gamma passing rates with the 3%/3 mm gamma criterion of the scanning pattern and 25 fields were 99.2% and 99.8%, respectively.

Conclusions:
This system can be effective for QA determinations of spot size, spot position, field flatness, and field symmetry over 360° of gantry rotation in a time- and cost-effective manner, with spatial resolution comparable to that of EBT3 film.