bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cohort profile: The Health, Food, Purchases and Lifestyle (SMIL) cohort – a Danish open cohort
Authors: Sørensen Kathrine Kold , Andersen Mikkel Porsborg , Møller Frederik Trier , Eves Caroline , Junker Thor Grønborg , Zareini Bochra , Torp-Pedersen Christian 
Published: March 2024

PurposeThe Health, Food, Purchases and Lifestyle (SMIL) cohort is a prospective open Danish cohort that collects electronic consumer purchase data, which can be linked to Danish nationwide administrative health and social registries. This paper provides an overview of the cohort’s baseline characteristics and marginal differences in the monetary percentage spent on food groups by sex, age and hour of the day.ParticipantsAs of 31 December 2022, the cohort included 11 214 users of a smartphone-based receipt collection application who consented to share their unique identification number for linkage to registries in Denmark. In 2022, the composition of the cohort was as follows: 62% were men while 24% were aged 45–55. The cohort had a median of 63 (IQR 26–116) unique shopping trips. The cohort included participants with a range of health statuses. Notably, 21% of participants had a history of cardiovascular disease and 8% had diabetes before donating receipts.Findings to dateThe feasibility of translating consumer purchase data to operationalisable food groups and merging with registers has been demonstrated. We further demonstrated differences in marginal distributions which revealed disparities in the amount of money spent on various food groups by sex and age, as well as systematic variations by the hour of the day. For example, men under 30 spent 8.2% of their total reported expenditure on sugary drinks, while women under 30 spent 6.5%, men over 30 spent 4.3% and women over 30 spent 3.9%.Future plansThe SMIL cohort is characterised by its dynamic, continuously updated database, offering an opportunity to explore the relationship between diet and disease without the limitations of self-reported data. Currently encompassing data from 2018 to 2022, data collection is set to continue. We expect data collection to continue for many years and we are taking several initiatives to increase the cohort.
Exploring the pharmacists’ role in optimising antithrombotic therapy in primary care: a qualitative study
Authors: van Paassen Jacqueline G , Tan Jaïr P , Deneer Vera H M , Bouvy Marcel L 
Published: March 2024

ObjectiveIn antithrombotic therapy, the balance between efficacy and safety is delicate, which makes it challenging for healthcare professionals, including pharmacists, to optimise therapy. Pharmacists may play an important role in optimising antithrombotic therapy, but especially in primary care, this role has not been elucidated. Here, we study how community pharmacists (pharmacists in primary care) perceive their current and future role in antithrombotic therapy.DesignWe conducted a qualitative study using semi-structured interviews. The interview protocol and subsequent analysis were based on the Theoretical Domains Framework, and the findings were interpreted with the Capability Opportunity Motivation – Behaviour System.Setting and participantsThe interview participants were community pharmacists, located across the Netherlands, from the Utrecht Pharmacy Practice network for Education and Research.ResultsWe interviewed 16 community pharmacists between February and August 2021 and identified several major themes which were important for the pharmacist’s role in antithrombotic therapy. Pharmacists felt responsible for the outcome of antithrombotic treatment and intended to invest in their role in antithrombotic therapy. Pharmacists did, however, experience barriers to their role in antithrombotic therapy, like a lack of access to clinical information such as the indication of antithrombotic treatment and a lack of specific knowledge on this treatment.ConclusionCommunity pharmacists perceive a role for themselves in antithrombotic therapy. To fulfil this role, several preconditions must be met.
Experiences of the clinical academic pathway: a qualitative study in Greater Manchester to improve the opportunities of minoritised clinical academics
Authors: Lin Chiu-Yi , Greco Cinzia , Radhakrishnan Hema , Finn Gabrielle M , Cowen Rachel L , Gardiner Natalie J 
Published: March 2024

ObjectivesThe aim of this study was to explore the barriers and facilitators faced by clinical academics (CAs) in the Greater Manchester region, with particular attention to the experiences of minoritised groups.DesignA qualitative study using semistructured interviews and focus groups was conducted. A reflexive thematic analysis was applied to identify key themes.SettingUniversity of Manchester and National Health Service Trusts in the Greater Manchester region.ParticipantsThe sample of this study was composed of 43 participants, including CAs, senior stakeholders, clinicians and medical and dental students.ResultsSix themes were identified. CAs face several barriers and facilitators, some of which—(1) funding insecurity and (2) high workload between the clinic and academia—are common to all the CAs. Other barriers, including (3) discrimination that translates into struggles with self-worth and feeling of not belonging, (4) being or being perceived as foreign and (5) unequal distribution of care duties, particularly affect people from minoritised groups. In contrast, (6) mentorship was commonly identified as one of the most important facilitators.ConclusionsCultural and structural interventions are needed, such as introducing financial support for early career CAs and intercalating healthcare students to promote wider social and cultural change and increase the feelings of belonging and representation across the entire CA pipeline.
Communication to adult patients undergoing cancer care by non-specialist nurses: a scoping review protocol
Authors: Kachimanga Chiyembekezo , McGlashan Jennifer , Cunningham Nicola , Hoyle Louise 
Published: March 2024

IntroductionLittle is known regarding how non-specialist nurses communicate with patients living with cancer when the patients are receiving care outside of their cancer units/teams. This scoping review aims to identify, examine and report on the currently available evidence about communication by non-specialist nurses when caring for adults living with cancer outside of their cancer care unit/teams.Methods and analysisA scoping review following the JBI methodology for scoping reviews will be conducted. We will search for empirical studies that meet the inclusion criteria in six databases (MEDLINE, PubMed, CINAHL, Embase, Scopus and PsycINFO). Handsearching in references of included articles will be performed to find additional articles. The population of interest will be non-specialist nurses. Three concepts will be explored, namely (1) all adult patients living with cancer, (2) a focus on three stages of the cancer continuum of care (cancer diagnosis, treatment and survivorship) and (3) a focus on communication between non-specialist nurses and patients living with cancer. We will include studies describing all healthcare settings outside patients’ specialised cancer units or oncology teams. After article selection, two reviewers will independently screen titles and abstracts and perform a full-text article review, risk of bias assessments and data extraction. A third reviewer will resolve all disagreements. A narrative summary will provide an overview of how the results relate to the research aims and questions. The included articles will be limited to English and published between 2012 and 2023.Ethics and disseminationNo ethical approval is required since we will use publicly available empirical research sources. This review will provide current research on communication by non-specialist nurses with patients with a cancer diagnosis outside of an oncology setting, evidence that will support effective communication. As such, we aim to disseminate the findings in academic conferences and peer-reviewed journals.
Circular RNA as a source of neoantigens for cancer vaccines
Authors: Ren Yi , Manoharan Thamizhanban , Liu Beijia , Cheng Cyrus Zai Ming , En Siew Bei , Cheong Wai-Kit , Lee Kai Yin , Tan Ian Jse-Wei , Lieske Bettina , Tan Ker-Kan , Chia Gloryn 
Published: March 2024

BackgroundThe effectiveness of somatic neoantigen-based immunotherapy is often hindered by the limited number of mutations in tumors with low to moderate mutation burden. Focusing on microsatellite-stable colorectal cancer (CRC), this study investigates the potential of tumor-associated circular RNAs (circRNAs) as an alternative source of neoepitopes in CRC.MethodsTumor-associated circRNAs in CRC were identified using the MiOncoCirc database and ribo-depletion RNA sequencing of paired clinical normal and tumor samples. Candidate circRNA expression was validated by quantitative real-time PCR (RT-qPCR) using divergent primers. TransCirc database was used for translation prediction. Human leukocyte antigen binding affinity of open reading frames from potentially translatable circRNA was predicted using pVACtools. Strong binders from messenger RNA-encoded proteins were excluded using BlastP. The immunogenicity of the candidate antigens was functionally validated through stimulation of naïve CD8+T cells against the predicted neoepitopes and subsequent analysis of the T cells through enzyme-linked immunospot (ELISpot) assay, intracellular cytokine staining (ICS) and granzyme B (GZMB) reporter. The cytotoxicity of T cells trained with antigen peptides was further tested using patient-derived organoids.ResultsWe identified a neoepitope from circRAPGEF5 that is upregulated in CRC tumor samples from MiOncoCirc database, and two neoepitopes from circMYH9, which is upregulated across various tumor samples from our matched clinical samples. The translation potential of candidate peptides was supported by Clinical Proteomic Tumor Analysis Consortium database using PepQuery. The candidate peptides elicited antigen-specific T cells response and expansion, evidenced by various assays including ELISpot, ICS and GZMB reporter. Furthermore, T cells trained with circMYH9 peptides were able to specifically target and eliminate tumor-derived organoids but not match normal organoids. This observation underscores the potential of circRNAs as a source of immunogenic neoantigens. Lastly, circMYH9 was enriched in the liquid biopsies of patients with CRC, thus enabling a detection-to-vaccination treatment strategy for patients with CRC.ConclusionsOur findings underscore the feasibility of tumor-associated circRNAs as an alternative source of neoantigens for cancer vaccines targeting tumors with moderate mutation levels.
Dinosaur biostratigraphy of the non-marine Cretaceous of Utah
Authors: Kirkland James I. , Sertich Joseph J. W. , Titus Alan L. 
Published: March 2024

Abstract
Over the past 30 years, exploration of the terrestrial Mesozoic section in Utah has resulted in a more than five-fold increase in the known species of dinosaurs. A highly resolved temporal and sequence stratigraphic framework for these strata is facilitating the utility of these newly discovered dinosaur assemblages in geological, evolutionary, palaeoecological and palaeogeographic research. Local subsidence due to salt tectonics in the northern Paradox Basin is responsible for this region of eastern Utah preserving basal Cretaceous dinosaur faunas, known nowhere else in North America, that document Jurassic–Cretaceous faunal turnover palaeobiogeographic connections across the proto-North Atlantic with Europe. The more medial Cretaceous strata west of the San Rafael Swell, in central Utah, preserve a unique dinosaur assemblage on an isolated North America. These strata also record the first immigration of Asian dinosaurs into North America and the last occurrences of a number of endemic North American dinosaur lineages. Through the Late Cretaceous, extensive, fossiliferous floodplain deposits are exposed in the high plateaus of southern Utah within the Grand Canyon Bight on the western side of the Late Cretaceous Western Interior Seaway. Research on microvertebrate sites has resulted in a diverse record of vertebrate life substage by substage through most of the Upper Cretaceous sequence. Particularly, rich dinosaur-bearing beds through the Campanian have resulted in the discovery of many new dinosaur species distinct from the coeval dinosaur-bearing beds farther north along the western coast of the Western Interior Seaway in Montana and Alberta. The further development of these numerous rich dinosaur assemblages will provide the basis for considerable research in the future.
Cell Context Is the Third Axis of Synergy for the Combination of ATR Inhibition and Cisplatin in Ewing Sarcoma
Authors: Jess Jennifer , Sorensen Katie M. , Boguslawski Elissa A. , Stout Matthew C. , Madaj Zachary B. , Caiello Benjamin P. , Pomaville Monica , Wilson Elizabeth R. , Kinn-Gurzo Seneca S. , Parker Curtis C. , Veluvolu Sridhar M. , Brysgel Taylor V. , Kaufman Rebecca , Kitchen-Goosen Susan M. , Gedminas Jenna M. , Grohar Patrick J. 
Published: March 2024

Abstract

Purpose:
The importance of cellular context to the synergy of DNA damage response (DDR)-targeted agents is important for tumors with mutations in DDR pathways, but less well-established for tumors driven by oncogenic transcription factors. In this study, we exploit the widespread transcriptional dysregulation of the EWS-FLI1 transcription factor to identify an effective DDR-targeted combination therapy for Ewing sarcoma.

Experimental Design:
We used matrix drug screening to evaluate synergy between a DNA-PK inhibitor (M9831) or an ATR inhibitor (berzosertib) and chemotherapy. The combination of berzosertib and cisplatin was selected for broad synergy, mechanistically evaluated for Ewing sarcoma selectivity, and optimized for in vivo schedule.

Results:
Berzosertib combined with cisplatin demonstrates profound synergy in multiple Ewing sarcoma cell lines at clinically achievable concentrations. The synergy is due to loss of expression of the ATR downstream target CHEK1, loss of cell-cycle check-points, and mitotic catastrophe. Consistent with the goals of the project, EWS-FLI1 drives the expression of CHEK1 and five other ATR pathway members. The loss of CHEK1 expression is not due to transcriptional repression and instead caused by degradation coupled with suppression of protein translation. The profound synergy is realized in vivo with a novel optimized schedule of this combination in subsets of Ewing sarcoma models, leading to durable complete responses in 50% of animals bearing two different Ewing sarcoma xenografts.

Conclusions:
These data exploit EWS-FLI1 driven alterations in cell context to broaden the therapeutic window of berzosertib and cisplatin to establish a promising combination therapy and a novel in vivo schedule.
See related commentary by Ohmura and Grünewald, p. 3358
Evaluation of blow fly, Chrysomya megacephala (Calliphoridae: Diptera) as an alternate source of protein in broiler feed
Authors: Sajjad M. , Sajjad A. , Chishti G.A. , Binyameen M. , Abbasi A. , Haq I.U. , Gaafar A.Z. , Hodhod M.S. 
Published: March 2024

Abstract
Poultry industry is one of the fastest growing agri-businesses in the world. However, the usage of expensive soybean meal and fishmeal as poultry feed ingredients is making it less profitable and environmentally unsustainable. Insects are becoming more popular as an alternate protein source in poultry feed because they are more sustainable, cost-efficient and eco-friendly than most of the conventional poultry feed sources. In the present study, we replaced 4%, 8% and 12% soybean meal with blow fly, Chrysomya megacephala (Calliphoridae: Diptera) larvae and evaluated its impact on growth performances, hematological parameters, intestinal morphometry and meat quality of Ross 308 broiler. For comparison, we also evaluated commercially available full fat Hermetia illucens (Stratiomyidae: Diptera) larvae. Three hundred and fifty 1-day-old chicks with initial weight of 40.28 g/chick were randomly divided into seven experimental diets (5 pens per treatment and 10 birds per pen). All the dietary treatments were isocaloric and isonitrogenous, meeting the nutrient requirements of the broilers. The results revealed that the broiler fed on 12% C. megacephala or H. illucens had significantly higher () live weight, average daily weight gain and better feed conversion ratios. The diets containing 12% C. megacephala or H. illucens significantly improved the blood haematology and serum bio-chemistry in the broiler. The gut histological indices of jejunum and ileum such as villus height (Vh), crypt depth (Cd), villus width (Vw), and Vh/Cd ratios also improved by the feeding of 12% C. megacephala and H. illucens diets. The broiler fed on 12% H. illucens diet showed higher L* (lightness) and a* (redness), while those fed on 12% C. megacephala showed higher b* (yellowness) in breast meat (Pectoralis major). Both species performed equally well in growth performance, haematology, serum bio-chemistry, gut histology and meat quality. It was concluded that replacement of soybean meal with 12% C. megacephala or H. illucens larvae improves the growth performance, blood haematology, gut histology and meat color and lightness traits of broiler and thus can be used as an alternate source of protein in broiler feed.
Assessment of U.S. Urban Surface Temperature Using GOES-16 and GOES-17 Data: Urban Heat Island and Temperature Inequality
Authors: Lee Jangho 
Published: March 2024

Abstract
This study utilizes hourly land surface temperature (LST) data from the Geostationary Operational Environmental Satellite (GOES) to analyze the seasonal and diurnal characteristics of surface urban heat island intensity (SUHII) across 120 largest U.S. cities and their surroundings. Distinct patterns emerge in the classification of seasonal daytime SUHII and nighttime SUHII. Specifically, the enhanced vegetation index (EVI) and albedo (ALB) play pivotal roles in influencing these temperature variations. The diurnal cycle of SUHII further reveals different trends, suggesting that climate conditions, urban and nonurban land covers, and anthropogenic activities during nighttime hours affect SUHII peaks. Exploring intracity LST dynamics, the study reveals a significant correlation between urban intensity (UI) and LST, with LST rising as UI increases. Notably, populations identified as more vulnerable by the social vulnerability index (SVI) are found in high UI regions. This results in discernible LST inequality, where the more vulnerable communities are under higher LST conditions, possibly leading to higher heat exposure. This comprehensive study accentuates the significance of tailoring city-specific climate change mitigation strategies, illuminating LST variations and their intertwined societal implications.
In-line monitoring of cryogenic three-point bending test of fiber-reinforced composites using acoustic emission
Authors: Maack Björn 
Published: March 2024

Remotely in-line monitored acoustic emission (AE) of interlaminar shear strength tests in a 3-point bending test of fiber-reinforced polymer composites (FRP) conducted under cryogenic conditions in liquid nitrogen (LN2) were studied. The AE sensors were reversibly mounted at the outer components of the testing machine to thermally decouple them from the cryogenic area and use AE signal transmission through the testing machine structure as a waveguide. The damage mechanisms and effect of the cryogenic temperature were studied at 296 K room temperature (RT) and in LN2 at 77 K, considering machine and process noises. The correlation of machine data with acoustics and the AE hit analysis revealed matrix cracking as the most frequent damage mechanism under both conditions but with different failure mechanisms. At RT and applying higher loads, the most damage suddenly occurred, and the specimen failed. In LN2, the damage occurred continuously from the beginning of testing. The amount of fiber failure increased, and the AE feature ranges enlarged. This study presents a method by AE for remote monitoring the mechanical response of FRP in cryogenic fluids such as liquid hydrogen. The method provides a new approach to support the more efficient development of FRP materials for storage vessel structures and structural health monitoring systems.
A Taxonomy of Subjective Control: Teachers‘ Narrative Accounts of a Teacher Evaluation System
Authors: Pallas Aaron M. , Touloukian Cami 
Published: March 2024

Background or Context: Federal and state reforms have expanded accountability systems for school districts, schools, and teachers. However, there is little evidence that the implementation of new teacher evaluation systems relying on measures of student learning and measures of teaching practice, with differentiated performance categories and rewards and sanctions, have had broad positive influences on teaching practice and student learning. Purpose, Objective, Research Question, or Focus of Study: We seek to contribute to an understanding of the modest influence of teacher evaluation systems by focusing on the targets of the policies—teachers—and how they experience the evaluation systems. Drawing on principal-agent theory and control-value theory, each of which suggests that teacher control over their performance evaluations influences their behavioral responses to them, we develop a taxonomy of teachers’ narratives of their subjective control of their evaluations. Research Design: We interviewed 141 New York City teachers working in 27 traditional elementary, middle, and high schools in the 2015–16 school year, asking about their experiences with Advance, the New York City annual teacher evaluation system. We developed a thematic analysis system for coding and analyzing the interviews that began with a set of categories reflective of the larger project’s research questions and prior research on performance evaluation in general and teacher evaluation in particular. All told, we coded 4,077 excerpts from the 141 teacher interviews, an average of about 29 excerpts per interview. Findings: Seventy-one percent of the teachers in our sample indicated that they had no control over some aspect of their teacher evaluation ratings. Teachers noted three areas in their ratings that they deemed out of their control: other people’s behaviors, notably students, teachers, and the administrators observing and rating their classroom practice; the technology of teacher evaluation, especially the features of observation rubrics and student assessments, and for some teachers, statistical models; and the broader social context of the school, particularly the resources available to support teachers and students and the uncertainties of students’ home lives. A small number of teachers noted their control over their teaching practices and control over their own thoughts and behaviors. Conclusions or Recommendations: This study was situated in New York City at a time when many teachers believed the teacher evaluation system was designed to be punitive. Under these circumstances, teachers’ responses to the evaluation system hinge on their trust in school leadership and their perceptions of how much voice they have in the design and implementation of the system. This trust is enhanced when teachers have confidence that principals are able to observe their practice accurately and consistently.