bluuebunny/crossref_metadata_2025_split huggingface dataset:
Capecitabine-induced-coronary-vasospasm leading to polymorphic ventricular tachycardia and cardiac arrest
Authors: Kabat Maciej , Padalkar Roma , Hazaveh Sara , Joseph Vladimir , Feigenblum David , Sadikot Sean 
Published: February 2024

AbstractCapecitabine, a pro-drug of 5-fluorouracil, is commonly used in the treatment of breast and colorectal cancer. Its side effects, including nausea, vomiting, diarrhea, fatigue, loss of appetite, and bone marrow suppression, are well recognized. However, coronary vasospasm represents a less commonly recognized but significant complication of fluoropyrimidine-based therapies such as capecitabine. Proposed mechanisms for this adverse effect complication include direct endothelium-independent vasoconstriction, activation of protein kinase C, and activation of the cyclooxygenase pathway. In this report, we present a case of capecitabine-induced coronary vasospasm leading to progressive, focal ST-elevations, myocardial ischemia, and subsequently polymorphic ventricular tachycardia. These events were captured on telemetry, in a male in his early 40s, diagnosed with stage IIIB sigmoid colon cancer. Notably, the patient had no pre-existing coronary artery disease or other cardiovascular risk factors. Upon diagnosis, the patient was initiated on a calcium channel blocker, verapamil, to mitigate further coronary vasospasm events. After thorough discussions that prioritized the patient’s input and values, an implantable cardioverter-defibrillator was placed subcutaneously. Following discharge, the patient restarted capecitabine therapy along with verapamil prophylaxis and did not experience any subsequent shocks from his ICD as assessed during his outpatient follow-up visits. This case emphasizes the need to involve patients in decision-making processes, especially when managing unexpected and serious complications, to ensure treatments align with their quality of life and personal preferences.
The effect of attention shifting on Chinese children’s word reading in primary school
Authors: Zhou Hui , Jiang Meiling 
Published: February 2024

Abstract
Background
This study explored the effects of attention shifting on Chinese children’s word reading.

Objective
The sample consisted of 87 fourth-grade children from Shaoxing City, China.

Methods
The students completed measures of the attention shifting task, reading accuracy test, reading fluency test, and rapid automatized naming test.

Results
The results showed that reading fluency was significantly correlated with attention shifting scores, specifically with tag1 and tag6 (ps < 0.05). The reading accuracy score was also significantly correlated with tag6 (p < 0.05). According to the regression analysis of attention shifting on word reading, even when controlling for rapid automatic naming, attention shifting significantly affected word reading fluency at approximately 600 ms (p = .011). Attention shifting did not affect children’s word reading accuracy.

Short conclusion
These findings suggest that attention shifting is significantly associated with children’s word reading. Educators should focus on developing children’s attention shifting to improve their word reading ability.
Role of interfaces on the mechanical response of accumulative roll bonded nanometallic laminates investigated via dislocation dynamics simulations
Authors: Chakraborty Aritra , Kohnert Aaron A. , Hunter Abigail , Capolungo Laurent 
Published: February 2024

AbstractUnraveling the effects of continuous dislocation interactions with interfaces, particularly at the nanometer length scales, is key to a broader understanding of plasticity, to material design and to material certification. To this end, this work proposes a novel discrete dislocation dynamics-based model for dislocation interface interactions tracking the fate of residual dislocation on interfaces. This new approach is used to predict the impact of dislocation/interface reactions on the overall mechanical behavior of accumulative roll bonded nanometallic laminates. The framework considers the dynamic evolution of the interface concurrent with a large network of dislocations, thus, accounting for the local short and long range effects of the dislocations under the external boundary conditions. Specifically, this study focuses on two-phase Fe/Cu nanometallic laminates, and investigates the role of the underlying elastic and plastic contrast of the Fe and the Cu layers on the composite response of the material. Moreover, the role of initial microstructures, resulting from processing is also investigated. Subsequently, the model is used to examine the effect of layer thickness and interface orientation relationship on the residual stresses of the relaxed microstructure. The associated mechanical response of these laminates are compared when loaded under normal direction compression, as well as shear compression. Finally, this work predicts a dominant effect of the layer thickness, as compared to the interface orientation relationship, on the macroscopic response and on the residual stresses of these nanolaminates, while the local dislocation transmission propensity through the interface is significantly influenced by the corresponding orientation relationship.
PTCH1-mutant human cerebellar organoids exhibit altered neural development and recapitulate early medulloblastoma tumorigenesis
Authors: van Essen Max J. , Apsley Elizabeth J. , Riepsaame Joey , Xu Ruijie , Northcott Paul A. , Cowley Sally A. , Jacob John , Becker Esther B. E. 
Published: February 2024

ABSTRACT
Patched 1 (PTCH1) is the primary receptor for the sonic hedgehog (SHH) ligand and negatively regulates SHH signalling, an essential pathway in human embryogenesis. Loss-of-function mutations in PTCH1 are associated with altered neuronal development and the malignant brain tumour medulloblastoma. As a result of differences between murine and human development, molecular and cellular perturbations that arise from human PTCH1 mutations remain poorly understood. Here, we used cerebellar organoids differentiated from human induced pluripotent stem cells combined with CRISPR/Cas9 gene editing to investigate the earliest molecular and cellular consequences of PTCH1 mutations on human cerebellar development. Our findings demonstrate that developmental mechanisms in cerebellar organoids reflect in vivo processes of regionalisation and SHH signalling, and offer new insights into early pathophysiological events of medulloblastoma tumorigenesis without the use of animal models.
Diagnostic Overshadowing of Psychological Disorders in People With Intellectual Disability: A Systematic Review
Authors: Dell’Armo Kristin , Tassé Marc J. 
Published: February 2024

Abstract
Diagnostic overshadowing is a bias in which symptoms of a psychological disorder are falsely attributed to a known diagnosis of intellectual disability. This systematic review evaluated all research on diagnostic overshadowing conducted to date, including dissertations and peer-reviewed journal articles. In total, 25 studies were included in this review. Findings suggest diagnostic overshadowing may not be as ubiquitous as originally believed, with one third of included studies finding no overshadowing. The quality of the evidence was graded as “Low” using the LEGEND tool, with common issues including outdated studies, analogue methodologies, small sample sizes and convenience samples, and inappropriate conducting or reporting of statistical analyses. Implications for the field and recommendations for future research are discussed.
Postschool Goal Expectations for Youth With Intellectual and Developmental Disabilities
Authors: Wu Yi-Chen , Qian Xueqin , Lee Seunghee , Johnson David R. , Thurlow Martha L. 
Published: February 2024

Abstract
Using National Longitudinal Transition Study 2012 data, this study explored parent and youth expectations in the areas of postsecondary education, employment, independent living, and financial independence. Compared to youth with other disabilities, youth with intellectual and developmental disabilities and their parents had much lower expectations for the four postschool goals, and parent expectations were much lower than youth’s own expectations. Also, youth’s race, along with their daily living skills and functional abilities, were positively associated with parent and youth expectations in several future goal areas. Our discussion highlights implications for improving the transition experiences of youth with intellectual and developmental disabilities.
Impact of combined pulmonary fibrosis and emphysema on lung cancer risk and mortality in rheumatoid arthritis: A multicenter retrospective cohort study
Authors: Mori Shunsuke , Ueki Yukitaka , Hasegawa Mizue , Nakamura Kazuyoshi , Nakashima Kouya , Hidaka Toshihiko , Ishii Koji , Kobayashi Hironori , Miyamura Tomoya 
Published: February 2024

Objective
Combined pulmonary fibrosis and emphysema (CPFE) is a syndrome characterized by the coexistence of emphysema and fibrotic interstitial lung disease (ILD). The aim of this study was to examine the effect of CPFE on lung cancer risk and lung cancer-related mortality in patients with rheumatoid arthritis (RA).

Methods
We conducted a multicenter retrospective cohort study of patients newly diagnosed with lung cancer at five community hospitals between June 2006 and December 2021. Patients were followed until lung cancer-related death, other-cause death, loss to follow-up, or the end of the study. We used the cumulative incidence function with Gray’s test and Fine-Gray regression analysis for survival analysis.

Results
A total of 563 patients with biopsy-proven lung cancer were included (82 RA patients and 481 non-RA patients). The prevalence of CPFE was higher in RA patients than in non-RA patients (40.2% vs.10.0%) at lung cancer diagnosis. During follow-up, the crude incidence rate of lung cancer-related death was 0.29 and 0.10 per patient-year (PY) in RA and non-RA patients, and 0.32 and 0.07 per PY in patients with CPFE and patients without ILD or emphysema, respectively. The estimated death probability at 5 years differed between RA and non-RA patients (66% vs. 32%, p<0.001) and between patients with CPFE and patients without ILD or emphysema (71% vs. 24%, p<0.001). In addition to clinical cancer stage and no surgery within 1 month, RA and CPFE were identified as independent predictive factors for increased lung cancer-related mortality (RA: adjusted hazard ratio [HR], 2.49; 95% confidence interval [CI], 1.65–4.76; CPFE: adjusted HR 2.01; 95% CI 1.24–3.23).

Conclusions
RA patients with lung cancer had a higher prevalence of CPFE and increased cancer-related mortality compared with non-RA patients. Close monitoring and optimal treatment strategies tailored to RA patients with CPFE are important to improve the poor prognosis of lung cancer.
The Effect of Composition, Pyrolysis Temperature and Adhesive Concentration on the Proximate Content and Calorific Value of Biobriquettes from Durian Skin, Corn husk and Fish Bones Waste
Authors: Novitrie Nora Amelia , Setiani Vivin , Camalia Aisyah Dinda 
Published: February 2024

Briquettes are an alternative energy derived from biomass. Biomass material can be obtained from plantation waste such as durian peel, agricultural waste such as corn husk and waste from the fisheries sector such as fish bones. Waste of corn husks, durian peel and fish bones have the potential to become biomass material as an alternative energy. The aim of this research is to analyze the effect of variations in composition, pyrolysis temperature and adhesive concentration on the quality of biobriquettes and emissions resulting from the combustion process. The dried waste materials is then pyrolyzed for 4 hours at 350 ℃ and 500 ℃. Proximate testing was carried out to determine the quality of the biobriquettes. The parameters analyzed in this test include moisture content, ash content, volatile matter content, bound carbon content and heating value. The results of the study revealed that the best sample variations were found in briquettes with a composition of 50% durian peel [T1] [c2] : 50% corn husk with a pyrolysis temperature of 350℃ and an adhesive concentration of 7%. The level of CO emissions produced when burning briquettes is 1,700 mg/Nm3 and SO2 is 0.741 mg/Nm3.
Inorganic Waste Reduction Planning with The Implementation of Dipo Waste Bank (DWB) and Reverse Vending Machine (RVM) at Diponegoro University
Authors: Sumiyati Sri , Budihardjo Mochamad Arief , Ramadhan Bimastyaji Surya , Warsito Budi , Kusumasasmita Hanif , Rahman Ghifar , Putra Setiadi Hizkia Christian 
Published: February 2024

Plastic waste is a global environmental problem that has existed for a long time and has not been resolved. On a worldwide scale, solid waste increased to 9.1 billion tons, of which 6.9 billion tons was plastic waste. Undip is one of the largest public universities. As one of the universities that supports the achievement of SDGs Number 12 concerning waste management, Diponegoro University has a Waste Bank, namely the Dipo Waste Bank (DWB). The method used in this study is mass balance. Based on the projected waste generation from 2021-2030, the era of inorganic waste in the composition of plastic bottles at Undip is 42,577 kg/day. DWB is expected to realize independent and sustainable waste management within Diponegoro University (UNDIP). In its course, waste management efforts are felt to be lacking due to several obstacles and participation that are not optimal. There are three scenarios of reducing inorganic waste of plastic bottles in the study, namely the baseline scenario, the Dipo Waste Bank (DWB) scenario can achieve the target of 20% of waste that can be recovered by DWB and Reverse Vending Machine (RVM).
Roadmap for the expression of canonical and extended endocannabinoid system receptors and metabolic enzymes in peripheral organs of preclinical animal models
Authors: Rosado‐Franco J. J. , Ellison A. L. , White C. J. , Price A. S. , Moore C. F. , Williams R. E. , Fridman L. B. , Weerts E. M. , Williams D. W. 
Published: February 2024

AbstractThe endocannabinoid system is widely expressed throughout the body and is comprised of receptors, ligands, and enzymes that maintain metabolic, immune, and reproductive homeostasis. Increasing interest in the endocannabinoid system has arisen due to these physiologic roles, policy changes leading to more widespread recreational use, and the therapeutic potential of Cannabis and phytocannabinoids. Rodents have been the primary preclinical model of focus due to their relative low cost, short gestational period, genetic manipulation strategies, and gold‐standard behavioral tests. However, the potential for lack of clinical translation to non‐human primates and humans is high as cross‐species comparisons of the endocannabinoid system have not been evaluated. To bridge this gap in knowledge, we evaluate the relative gene expression of 14 canonical and extended endocannabinoid receptors in seven peripheral organs of C57/BL6 mice, Sprague–Dawley rats, and non‐human primate rhesus macaques. Notably, we identify species‐ and organ‐specific heterogeneity in endocannabinoid receptor distribution where there is surprisingly limited overlap among the preclinical models. Importantly, we determined there were no receptors with identical expression patterns among mice (three males and two females), rats (six females), and rhesus macaques (four males). Our findings demonstrate a critical, yet previously unappreciated, contributor to challenges of rigor and reproducibility in the cannabinoid field, which has implications in hampering progress in understanding the complexity of the endocannabinoid system and development of cannabinoid‐based therapies.
Estimation of greenhouse gas emissions from rice and annual upland crops in Red River Delta of Vietnam using the denitrification–decomposition model
Authors: Trang Bui Thi Thu , Van Trinh Mai 
Published: February 2024

Abstract
This study used the denitrification–decomposition (DNDC) model and ArcGIS 10.1 to calculate and quantify the greenhouse gas (GHG) potential from rice and annual upland crops in the Red River Delta of Vietnam. GHG emissions were monitored, analyzed, and calculated at experimental sites. The operating mechanism, sensitivity analysis of the parameters, calibration, and verification of the DNDC model for the GHG emission calculation were studied and performed, and a set of parameters was built. A good correlation between actual and simulated values was shown. From the data set of meteorological stations in and around the Red River Delta, the current land-use map, the topographic and soil map, a complex map of meteorology–soil–land use was built. Each unit of this map contains complete information about climate, soil, and crops as input data for modeling GHG emissions from crop production. From the spatial analysis and collected input data, GHG emissions were measured and calculated for the cultivated field of the Red River Delta (annual rice and upland crops) using the DNDC model. The model's outputs were used to build thematic maps on the distribution of global warming potential (CH4, N2O) for each unit of the complex map of climate, soil, and crops.
Eco-friendly palm oil directed synthesis of mesoporous titania for photocatalytic application
Authors: Thangaraj Preethi , Balachandran Abarna , Ramamurthy Rajarajeswari G. 
Published: February 2024

Abstract
Utilisation of templates facilitates the synthesis of titania samples with improved physico-chemical properties. When biomaterials are utilised as templates in the creation of inorganic materials, they can lead to constructed mesostructures via cost-effective and environmentally friendly synthetic pathways. Based on this context, the goal of this study was to assess the impact of palm oil on the surface properties and crystallite characteristics of titania nanoparticles. In this work, the various physico-chemical parameters such as thermal, surface area, porosity, crystallinity, chemical composition, textural and morphological characteristics of the palm oil (PO) templated titania were studied using various analysis techniques. Palm oil templated titania samples were synthesised using various amounts of palm oil as templates. The sample generated with a molar ratio of PO over titania precursor of 0.07 possessed large surface area (74.5 m2 g−1), small particle size (13.4 nm), uniformly dispersed spherical particles with good morphology and porosity among the various templated titania produced in this work. In addition, it was found to possess maximum photocatalytic efficiency in degrading the target 4-chlorophenol under UV irradiation.
Influence of graphene concentration on the properties of the composite prepared with poly(2-ethyl aniline) by mechanochemical method
Authors: Anaklı Duygu 
Published: February 2024

Abstract
In this study, poly(2-ethyl aniline)/graphene composites were prepared by a mechanochemical method, through in-situ polymerization of 2-ethyl aniline in the presence of graphene at different concentrations. Vickers microhardness, elastic modulus and electrical conductivity measurements were carried out as a function of the graphene concentration in the composite. Increasing the graphene content of the composite resulted in an increase in the conjugation length and carrier mobility of the polymer, and thus in the electrical conductivity of the composites. However, thermogravimetric analysis showed that the thermal stability of poly(2-ethyl aniline) increased with increasing graphene concentration. This study suggests the potential of graphene concentration to efficiently modify the morphological, electrical, mechanical, and thermal properties of poly(2-ethyl aniline).
Decline in case rates of youth onset type 2 diabetes in year three of the COVID-19 pandemic
Authors: Kim Ahlee , Geller David , Min Hyojin , Miyazaki Brian , Raymond Jennifer , Vidmar Alaina P. , Zipursky Rachel , Chao Lily C. 
Published: February 2024

Abstract

Objectives
To determine changes in case rates of youth onset type 2 diabetes in the three years following the COVID-19 pandemic.

Methods
A single-center, retrospective medical record review was conducted for patients newly diagnosed with T2D between 3/1/18 and 2/28/23 at a pediatric tertiary care center. The number of patients referred to CHLA with a T2D diagnosis date between 3/1/2020 and 2/28/2023 was compared to historical rates between 3/1/2018 and 2/29/2020. χ2 or Fisher’s exact test was used to compare categorical variables between each year and 2019.

Results
Compared to prepandemic baseline (3/1/19–2/29/20, 11.8±3.7 cases/month), there was a significant increase in new T2D monthly case rates in pandemic year 1 (3/1/20–2/28/21, 20.1±6.0 cases/month, 171 %, p=0.005) and pandemic year 2 (3/1/21–2/28/22, 25.9±8.9 cases/month, 221 %, p=0.002). Case rates declined in pandemic year 3 to 14.5±4.1 cases/month (3/1/22–2/28/23, p=0.43). Compared to prepandemic year 1, the frequency of DKA at diagnosis was higher in pandemic year 1 (13.3 vs. 5.0 %, p=0.009). The DKA rate in pandemic years 2 (6.8 %) and 3 (3.4 %) were comparable to prepandemic year 1 (p=0.53 and 0.58, respectively).

Conclusions
Youth onset type 2 diabetes cases and DKA rates in year 3 of the pandemic have returned to prepandemic level.
Learning how to mean in a second language: uses of system networks in L2 education
Authors: Arús-Hita Jorge , Matthiessen Christian M.I.M. , Xuan Winfred Wenhui 
Published: February 2024

Abstract
While approaches informed by Systemic Functional Linguistics (SFL) have been widely applied to the field of language education since the 1960s, the idea of the system embodying the meaning potential of language in context, represented as a system network, could be used to make a much more significant contribution to second language (L2) or foreign language education, where despite pioneering efforts the uptake of SFL has been less than in L1 education. In this paper, we will take stock of the ways system networks have been used in studies concerned with L2 education and at the same time we will highlight new opportunities to empower new studies and applications based on system networks as a way of engaging with the central notion of learning how to mean in a second/foreign language. We argue that system networks can make a very significant contribution to L2 education if they are given more attention and their deployment is highlighted. The uses considered in this paper include the following: Tracking language development systemically; diagnosing problems in L2 student texts; supporting sequencing in the curriculum of the learning of the L2 meaning potential; designing exercises based on options in system networks; guiding L2 learners by means of system networks as cartographic tools; contrasting L1 and L2 resources based on multilingual system networks; and supporting advanced L2 learners expanding their L2 uses by adding translation skills drawing on multilingual system networks. We will touch on these uses, highlighting those that have perhaps given the least attention in L2 education drawing on SFL, but which look very promising as we move ahead in the next couple of decades.
Crystal structure of (E)-3-(benzylideneamino)-2-phenylthiazolidin-4-one, C16H14N2OS
Authors: Seboletswe Pule , Zamisa Sizwe J. , Kumar Gobind , Singh Parvesh 
Published: February 2024

Abstract
C16H14N2OS, monoclinic, P21/n (no. 14), a = 13.8369(4) Å, b = 15.8967(4) Å, c = 13.8600(4) Å, β = 109.983(1)°, V = 2865.11(14) Å3, Z = 8, R
gt(F) = 0.0439, wR
ref(F
2) = 0.1091, T = 296.15 K.