bluuebunny/crossref_metadata_2025_split huggingface dataset:
Longitudinal Relationship Between Brain Atrophy Patterns, Cognitive Decline, and Cerebrospinal Fluid Biomarkers in Alzheimer’s Disease Explored by Orthonormal Projective Non-Negative Matrix Factorization
Authors: Shui Lan , Shibata Dean , Chan Kwun Chuen Gary , Zhang Wenbo , Sung Junhyoun , Haynor David R. ,   Alzheimer’s Disease Neuroimaging Initiative
Published: March 2024

Background: Longitudinal magnetic resonance imaging (MRI) has been proposed for tracking the progression of Alzheimer’s disease (AD) through the assessment of brain atrophy. Objective: Detection of brain atrophy patterns in patients with AD as the longitudinal disease tracker. Methods: We used a refined version of orthonormal projective non-negative matrix factorization (OPNMF) to identify six distinct spatial components of voxel-wise volume loss in the brains of 83 subjects with AD from the ADNI3 cohort relative to healthy young controls from the ABIDE study. We extracted non-negative coefficients representing subject-specific quantitative measures of regional atrophy. Coefficients of brain atrophy were compared to subjects with mild cognitive impairment and controls, to investigate the cross-sectional and longitudinal associations between AD biomarkers and regional atrophy severity in different groups. We further validated our results in an independent dataset from ADNI2. Results: The six non-overlapping atrophy components represent symmetric gray matter volume loss primarily in frontal, temporal, parietal and cerebellar regions. Atrophy in these regions was highly correlated with cognition both cross-sectionally and longitudinally, with medial temporal atrophy showing the strongest correlations. Subjects with elevated CSF levels of TAU and PTAU and lower baseline CSF Aβ42 values, demonstrated a tendency toward a more rapid increase of atrophy. Conclusions: The present study has applied a transferable method to characterize the imaging changes associated with AD through six spatially distinct atrophy components and correlated these atrophy patterns with cognitive changes and CSF biomarkers cross-sectionally and longitudinally, which may help us better understand the underlying pathology of AD.
Strategi Komunikasi Pemasaran Pariwisata Danau Toba Oleh Badan Pelaksana Otorita Danau TOba (BPODT) Dalam Pengembangan Branding “LAKE TOBA CALDERA OF KINGS”
Authors: Sagala Wiranda Tappang 
Published: March 2024

This research was conducted to analyze the marketing communication strategy of Lake Toba tourism and the obstacles of the Lake Toba Authority (BPODT) in developing the "Lake Toba Caldera of Kings" branding. The research method used is a descriptive method with a qualitative approach. The subjects in this study were two BPODT teams from the Public Communication and Marketing Division, while the triangulation informants were business people, community leaders and tourists. The results obtained are BPODT's communication strategy in developing Lake Toba branding through mass media such as: television, print media through newspapers and newspapers, booklets and new media by using social media sites and websites, such as Instagram, Twitter, Facebook, Youtube and Tiktok. BPODT has built new destinations in the authoritative zone, namely The Kaldera Nomadic Escape and the coordinative zone, namely the Tigarihit Colorful Village Tourism Village in Parapat. BPODT's obstacles in promoting Lake Toba tourism are the lack of tourism human resources both in quantity and quality, the lack of community roles in maintaining cleanliness, hospitality, and innovation in creating tourism products. While the infrastructure, there are still many road accesses to several Lake Toba attractions that are not feasible. Internet access and transportation are still inadequate and there is a lack of new tourist attractions in the Lake Toba area.
THE ROLE OF MARKETING CAPABILITIES IN MEDIATING THE INFLUENCE OF MANAGER CAPABILITIES TOWARD SALES FORCE ACHIEVEMENT
Authors: Gunawan Gunawan , SIAM STIVENES TJIN 
Published: March 2024

<p align="center"><strong>ABSTRACT</strong></p><p><strong> The increasingly competitive sales environment has led business practitioners, especially managers, to consistently emphasize their sales teams to achieve desired performance. Sales organizations are challenged to compete and create sustainable competitive advantages to achieve optimal sales performance. The role of Organizational Competitive Orientation, rarely studied specifically, has seen limited attention in research. Most marketing literature focuses on Market Orientation and its impact on Sales Force Performance. This study aims to explore the Mediating Role of Marketing Capabilities in the Influence of Managerial Capabilities on Salesperson Performance. The relationships among four constructs - Organizational Competitive Orientation, Managerial Capabilities, Marketing Capabilities, and Sales Force Performance - are analyzed using five hypotheses through Structural Equation Modeling (SEM). Additionally, one mediation hypothesis is tested using the Sobel Test, involving 200 sales force respondents from various industries in West Kalimantan.</strong></p><p><strong> </strong></p><p> </p>
Program inovasi produk dan penjualan e-commerce bagi pelaku usaha mikro kecil menengah (UMKM) batik
Authors: Muazza  , Asra Revis , Syuhada Siti , Mayasari  
Published: March 2024

Pengabdian yang dilakukan oleh dosen FKIP Universitas Jambi bekerjasama dengan pengrajin batik UMKM “Batik Istiqomah” agar dapat membuat suatu inovasi produk batik yang berkualitas dengan memanfaatkan kain batik perca bisa juga ditambah varian motif batik serta desain menjadi produk home decore yang dapat menarik minat dari konsumen batik dan dapat memasarkanya secara e-commerce, sehingga dapat mewujudkan laju keberlangsungan UMKM batik Jambi dan lebih mengenalkan batik Jambi secara luas. Untuk memperoleh data yang diperlukan lebih akurat dalam memecahkan permsaalahan yang dihadapi mitra dan mencapai tujuan dari kegiatan PkM ini digunakan metode agar program pelatihan inovasi produk dan penjualan e-commerce dari produk batik yang dihasilkan mitra dapat berjalan sesuai dengan target pengabdian ini maka metode yang digunakan Participatory Action Research (PAR) dengan pendekatan pelatihan melalui pendekatan klasikal, individual dan kolaboratif dengan metode cerah informatif, demonstrasi dan praktik. Hasil dari pengabdian ini berupa 1) Pelatihan inovasi produk perca batik yang tidak terpakai menjadi produk home decore seperti bantal sofa dan taplak meja; 2) Pelatihan penjualan e-commerce dalam pengabdian ini adalah pelatihan cara bagaimana memasarkan produk batik hasil dari UMKM khususnya Batik Istiqomah melalui media elektronik seperti shoppe, Lazada, Instagram dan lainya; 3) hasil evaluasi dan monitoring diketahui bahwa adanya pelatihan tersebut dapat membatu para pengrajin dalam kegiatan memproduksi membuat inovasi produk dari batik maupun proes penjualanya secara e-commerce.
The impact of increasing saline flush volume to reduce the amount of residual air in the delivery system of aortic prostheses—a randomized controlled trial
Authors: Szentiványi András , Borzsák Sarolta , Vecsey-Nagy Milán , Süvegh András , Hüttl Artúr , Fontanini Daniele Mariastefano , Szeberin Zoltán , Csobay-Novák Csaba 
Published: March 2024

BackgroundAir embolism is a known risk during thoracic endovascular aortic repair (TEVAR) and is associated with an incomplete deairing of the delivery system despite the saline lavage recommended by the instructions for use (IFU). As the delivery systems are identical and residual air remains frequently in the abdominal aortic aneurysm sac, endovascular aortic repair (EVAR) can be used to examine the effectiveness of deairing maneuvers. We aimed to evaluate whether increasing the flush volume can result in a more complete deairing.MethodsPatients undergoing EVAR were randomly assigned according to flushing volume (Group A, 1× IFU; Group B, 4× IFU). The Terumo Aortic Anaconda and Treo and Cook Zenith Alpha Abdominal stent grafts were randomly implanted in equal distribution (10-10-10). The quantity of air trapped in the aneurysm sac was measured using a pre-discharge computed tomography angiography (CTA). Thirty patients were enrolled and equally distributed between the two groups, with no differences observed in any demographic or anatomical factors.ResultsThe presence of air was less frequent in Group A compared to that in Group B [7 (47%) vs. 13 (87%), p = .02], and the air volume was less in Group A compared to that in Group B (103.5 ± 210.4 vs. 175.5 ± 175.0 mm3, p = .04). Additionally, the volume of trapped air was higher with the Anaconda graft type (p = .025).DiscussionThese findings suggest that increased flushing volume is associated with a higher amount of trapped air; thus, following the IFU might be associated with a reduced risk of air embolization. Furthermore, significant differences were identified between devices in terms of the amount of trapped air.
Clinical trial registration[NCT04909190], [ClinicalTrials.gov].
Indole-3-carboxyaldehyde does not reverse the intestinal effects of fiber-free diet in mice
Authors: Smits Mark M. , Dreyer Serafina I. L. , Hunt Jenna E. , Drzazga Anna K. , Modvig Ida M. , Holst Jens J. , Kissow Hannelouise 
Published: March 2024

ObjectiveFiber-free diet impairs intestinal and colonic health in mice, in parallel with a reduction in glucagon like peptide-1 (GLP-1) levels. Endogenous GLP-1 is important for intestinal growth and maintenance of the intestinal integrity. We aimed to investigate whether fiber-free diet reduces luminal content of metabolites which, upon supplementation, could increase GLP-1 secretion and restore the adverse effects of fiber-free diet.MethodsUntargeted metabolomics (LC-MS) was performed on colonic content of mice fed a fiber-free diet, identifying a metabolite of particular interest: indole-3-carboxyaldehyde (I3A). We exposed cultured GLUTag cells to I3A, and measured cumulative GLP-1 secretion. Isolated colon perfusions were performed in male C57BL/6JRj mice and Wistar rats. I3A was administered luminally or vascularly, and GLP-1 was measured in portal vein effluent. Finally, female C57BL/6JRJ mice were fed chow or fiber-free diet, with I3A or vehicle by oral gavage. After 10 days, plasma GLP-1 (ELISA) and intestinal permeability (FITC-dextran) were measured, animals were sacrificed and organs removed for histology.ResultsMice fed a fiber-free diet had significantly lower I3A in their colonic content compared to a control diet (7883 ± 3375 AU, p=0.04). GLP-1 secretion from GLUTag cells was unchanged after five minutes of exposure to I3A. However, GLP-1 levels increased after 120 minutes of exposure to 1 mM (60% increase, p=0.016) and 5 mM (89% increase, p=0.0025) I3A. In contrast, 48 h exposure to 1 mM decreased GLP-1 secretion (51% decrease, p&lt;0.001) and viability. In isolated perfused mouse and rat colon, I3A applied into the luminal or vascular side did not affect GLP-1 secretion. Mice fed a fiber-free diet tended to weigh less compared to chow fed mice; and the small intestine and colon were significantly smaller. No differences were seen in crypt depth, villus length, mucosal area, and intestinal permeability. Supplementing I3A did not affect body weight, morphology or plasma GLP-1 levels.ConclusionsFiber-free diet lowered colonic content of I3A in mice. I3A stimulates GLP-1 secretion in vitro, but not in animal studies. Moreover, it has no evident beneficial effect on intestinal health when administered in vivo.
MHIF-MSEA: a novel model of miRNA set enrichment analysis based on multi-source heterogeneous information fusion
Authors: Li Jianwei , Ma Xuxu , Lin Hongxin , Zhao Shisheng , Li Bing , Huang Yan 
Published: March 2024

Introduction: MicroRNAs (miRNAs) are a class of non-coding RNA molecules that play a crucial role in the regulation of diverse biological processes across various organisms. Despite not encoding proteins, miRNAs have been found to have significant implications in the onset and progression of complex human diseases.Methods: Conventional methods for miRNA functional enrichment analysis have certain limitations, and we proposed a novel method called MiRNA Set Enrichment Analysis based on Multi-source Heterogeneous Information Fusion (MHIF-MSEA). Three miRNA similarity networks (miRSN-DA, miRSN-GOA, and miRSN-PPI) were constructed in MHIF-MSEA. These networks were built based on miRNA-disease association, gene ontology (GO) annotation of target genes, and protein-protein interaction of target genes, respectively. These miRNA similarity networks were fused into a single similarity network with the averaging method. This fused network served as the input for the random walk with restart algorithm, which expanded the original miRNA list. Finally, MHIF-MSEA performed enrichment analysis on the expanded list.Results and Discussion: To determine the optimal network fusion approach, three case studies were introduced: colon cancer, breast cancer, and hepatocellular carcinoma. The experimental results revealed that the miRNA-miRNA association network constructed using miRSN-DA and miRSN-GOA exhibited superior performance as the input network. Furthermore, the MHIF-MSEA model performed enrichment analysis on differentially expressed miRNAs in breast cancer and hepatocellular carcinoma. The achieved p-values were 2.17e(-75) and 1.50e(-77), and the hit rates improved by 39.01% and 44.68% compared to traditional enrichment analysis methods, respectively. These results confirm that the MHIF-MSEA method enhances the identification of enriched miRNA sets by leveraging multiple sources of heterogeneous information, leading to improved insights into the functional implications of miRNAs in complex diseases.
Endovascular treatment of symptomatic severe intracranial atherosclerotic stenosis with a novel intracranial dedicated drug-eluting stent: a more effective treatment approach
Authors: Ma Lin , Wang Fei , Feng Hao , Yan Shuo , Xu Ji-Chong , Cheng Ying-Sheng , Fang Chun 
Published: March 2024

BackgroundEndovascular treatment of severe intracranial atherosclerotic stenosis (ICAS) using coronary drug-eluting stents (DESs) significantly reduces the risk of in-stent restenosis (ISR) and stroke recurrence. However, there are few reports regarding the treatment of ICAS with intracranial dedicated DES. Herein, we present our experience with the feasibility, safety, and medium-term follow-up outcomes of a novel intracranial DES, named NOVA stent, in patients with symptomatic severe ICAS (≥70%).MethodsFrom December 2021 to May 2022, patients with symptomatic severe ICAS who underwent implantation of the NOVA stent in our institution were retrospectively analyzed for procedural results, perioperative complications, imaging and clinical follow-up outcomes.ResultsTwenty-four patients, 16 (66.7%) with anterior circulation lesions and 8 (33.3%) with posterior circulation lesions, were enrolled. All patients with intracranial ICA (n = 6), middle cerebral artery (n = 10), basilar artery (n = 3), intracranial vertebral artery (n = 3), and the vertebrobasilar junction (n = 2) stenosis were treated successfully using NOVA stents. The severity of stenosis ranged from 75 to 96% (mean 85.9%) before treatment and this was reduced to 0 to 20% (mean 8.6%) immediately after stent placement. Symptomatic distal embolism occurred in one case; however, there were no other perioperative complications. The mean follow-up duration was 12.2 ± 1.06 months. No symptomatic ischemic events occurred during follow-up. Follow-up cerebral angiography was performed in 22 of 24 patients (91.7%), and significant ISR occurred in one patient (4.2%).ConclusionOur results demonstrate that implantation of the novel intracranial DES NOVA in severe ICAS is feasible, safe, and effective in selected cases, reducing the incidence of ISR, and showing excellent midterm clinical outcomes, providing a promising option for ICAS treatment.
TNF-α is a predictive marker in distinguishing myeloproliferative neoplasm and idiopathic erythrocytosis/thrombocytosis: development and validation of a non-invasive diagnostic model
Authors: Wang Zhenhao , Mei Yu , Yang Zhuming , Gao Qiang , Xu Hao , Han Zhiqiang , Hong Zhenya 
Published: March 2024

PurposePhiladelphia-chromosome negative myeloproliferative neoplasms (MPN) exhibit phenotypic similarities with JAK/STAT-unmutated idiopathic erythrocytosis and thrombocytosis (IE/IT). We aimed to develop a clinical diagnostic model to discern MPN and IE/IT.MethodsA retrospective study was performed on 77 MPN patients and 32 IE/IT patients in our center from January 2018 to December 2023. We investigated the role of hemogram, cytokine and spleen size in differentiating MPN and IE/IT among newly onset erythrocytosis and thrombocytosis patients. Independent influencing factors were integrated into a nomogram for individualized risk prediction. The calibration and discrimination ability of the model were evaluated by concordance index (C-index), calibration curve.ResultsMPN had significantly higher TNF-α level than IE/IT, and the TNF-α level is correlated with MF-grade. Multivariable analyses revealed that TNF-α, PLT count, age, size of spleen were independent diagnostic factors in differentiating MPN and IE/IT. Nomograms integrated the above 4 factors for differentiating MPN and IE/IT was internally validated and had good performance, the C-index of the model is 0.979.ConclusionThe elevation of serum TNF-α in MPN patients is of diagnostic significance and is correlated with the severity of myelofibrosis. The nomogram incorporating TNF-α with age, PLT count and spleen size presents a noteworthy tool in the preliminary discrimination of MPN patients and those with idiopathic erythrocytosis or thrombocytosis. This highlights the potential of cytokines as biomarkers in hematologic disorders.
Integrating UPLC-Q-Orbitrap MS with serum pharmacochemistry network and experimental verification to explore the pharmacological mechanisms of Cynanchi stauntonii rhizoma et radix against sepsis-induced acute lung injury
Authors: Gao Hejun , Yuan Ziyi , Liang Haoxuan , Liu Youtan 
Published: March 2024

Introduction: Patients with sepsis are at an incremental risk of acute lung injury (ALI). Baiqian, also known as Cynanchi stauntonii rhizoma et radix (Csrer), has anti-inflammatory properties and is traditionally used to treat cough and phlegm. This study aimed to demonstrate the multicomponent, multitarget, and multi-pathway regulatory molecular mechanisms of Csrer in treating lipopolysaccharide (LPS)-induced ALI.Methods: The bioactive components of Csrer were identified by ultrahigh-performance liquid chromatography Q-Orbitrap mass spectrometry (UPLC-Q-Orbitrap MS). Active targets predicted from PharmMapper. DrugBank, OMIM, TTD, and GeneCards were used to identify potential targets related to ALI. Intersection genes were identified for Csrer against ALI. The PPI network was analysed to identify prime targets. GO and KEGG analyses were performed. A drug–compound–target–pathway–disease network was constructed. Molecular docking and simulations evaluated the binding free energy between key proteins and active compounds. The protective effect and mechanism of Csrer in ALI were verified using an ALI model in mice. Western blot, Immunohistochemistry and TUNEL staining evaluated the mechanisms of the pulmonary protective effects of Csrer.Results: Forty-six bioactive components, one hundred and ninety-two potential cross-targets against ALI and ten core genes were identified. According to GO and KEGG analyses, the PI3K-Akt, apoptosis and p53 pathways are predominantly involved in the “Csrer–ALI” network. According to molecular docking and dynamics simulations, ten key genes were firmly bound by the principal active components of Csrer. The “Csrer–ALI” network was revealed to be mediated by the p53-mediated apoptosis and inflammatory pathways in animal experiments.Conclusion: Csrer is a reliable source for ALI treatment based on its practical components, potential targets and pathways.
Psychometric evaluation of the Chinese version of the burnout syndrome assessment scale in nurses
Authors: Xie Wenguang , Lu Tingting , Huang Xundong , Zhang Chao , Choudhary Mahima , Kumar Ashok 
Published: March 2024

ObjectiveThis study aimed to translate the Burnout Syndrome Assessment Scale (BOSAS) into Chinese and validate its reliability and validity among Chinese emergency department and ICU nurses.MethodsThe scale was translated into Chinese using Brislin’s translation principle. A total of 626 nurses from Jiangxi, Zhejiang, and Fujian provinces in China participated in an online questionnaire survey. The survey included the general information questionnaire for nurses developed by the research team and the Chinese version of the Burnout Syndrome Assessment Scale. Reliability and validity of the Chinese version of the scale were analyzed using SPSS.25 and AMOS.24 software.ResultsThe Chinese version of the Burnout Syndrome Assessment Scale consists of a total of 20 items, encompassing two dimensions: personal burnout and job burnout. This structure is consistent with the original English version of the scale. The Chinese version of BOSAS demonstrated high internal consistency, with a Cronbach’s α coefficient of 0.941. Additionally, the scale exhibited good split-half reliability (0.765) and test-retest reliability (0.871). The content validity index (S-CVI) was 0.971, indicating strong content validity. Exploratory factor analysis confirmed the same 2-factor structure as the original scale, and confirmatory factor analysis further validated this structure, with all fit indices indicating appropriateness.ConclusionThe Burnout Syndrome Assessment Scale has been successfully introduced and its reliability and validity have been verified in Chinese emergency department and ICU nurses.
Clinical differences between outpatients with and without internet addiction and emotional disorders: a prospective naturalistic outcome study
Authors: Zhou Jiaqi , Rosmarin David H. , Pirutinsky Steven 
Published: March 2024

Background/Objectiveas internet use becomes increasingly ingrained in contemporary society, internet addiction (IA) has emerged as a global public health concern. There is ongoing debate regarding whether IA represents a distinct psychological disorder or a secondary manifestation of other existing disorders. This study aimed to examine the pathological relationship between IA and emotional disorders (ED).Methodthis study compared pre-treatment characteristics and treatment process of three groups of patients (N=1292) in a naturalistic treatment setting: IA only, ED only, and comorbidity of IA and ED.Resultsthe IA only group differed from the other groups by reporting the highest levels of life satisfaction, adaptive emotion regulation, as well as risk behavior urges at intake. In addition, the IA only group displayed the lowest level of depressive and anxiety symptoms throughout the treatment.Conclusionour findings contribute to a better understanding of the discreteness of IA as a potential psychological disorder and inform more effective treatment strategies for IA and its comorbid conditions.