bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kikuchi‐Fujimoto lymphadenitis with cutaneous involvement
Authors: Rakic L. , Arrese J.E. , Thiry A. , Piérard G.E. 
Published: September 2006

AbstractWe report a case of Kikuchi‐Fujimoto disease with cutaneous involvement in a European man. In contrast, the disease is most prevalent in women of Asian descent. The condition is probably under‐recognized when histology is not used to identify lymphadenitis of protracted course. Skin lesions may mimic clinically other unrelated disorders including lymphomas and immune or infectious dermatoses. Histology of skin lesions may bring a clue to the diagnosis when apoptotic plasmacytoid monocytes are recognized. The relationship between Kikuchi‐Fujimoto disease and lupus erythematous remains a matter of debate.
Follicular mycosis fungoides: presentation of a case and review of the literature
Authors: Grau Cristina , Pont Virginia , Matarredona Jaime , Fortea José Miguel , Aliaga Adolfo 
Published: September 2006

AbstractFollicular mycosis fungoides is a rare variant of mycosis fungoides (MF). Structural‐wise there are several acneiform lesions made up of comedones, cysts and hyperkeratosis. The main histological finding is atypical lymphocytic infiltration around follicular structures, without epidermotropism. The association with follicular mucinosis is widely discussed in the literature. We report a case of follicular (MF) and review the cases published to date.
L‐carnitine supplementation in patients with cystic acne on isotretinoin therapy★
Authors: Georgala Sophia , Schulpis Kleopatra H. , Georgala Catherina , Michas Timos 
Published: September 2006

AbstractBackgroundPatients with cystic acne (CA) on Isotretinoin (Iso) therapy might present muscular symptoms as side effect of the drug. Myalgia, weakness, hypotension are also some of the main characteristics of carnitine (car) deficiency.MethodsTwo hundred and thirty (N= 230) patients with CA were treated with Isotretinoin (0.5 mg/kg per 24 h). All the patients were requested to visit our out‐patient department at the onset of muscular symptoms. Laboratory tests including car (total, free, acylcarnitine) were determined in blood and urine before treatment, at the onset of muscular symptoms and after the end of a 45 day study. Fifty percent of the patients with muscular involvement received l‐carnitine (100 mg/kg per 24 h per os) (group C) and 50% placebo (group P).ResultsTheir laboratory tests showed the well known increases of their liver enzymes and lipids, whereas car blood levels were remarkably decreased at the onset of their muscular symptoms and or at the end of the study. Their supplementation with l‐car, in patients of group C(N= 20) without Iso discontinuation or reduction, resulted in the disappearance of their muscular symptoms within 5–6 days and normalisation not only of the increased levels of their liver enzymes but also those of car, at the 45 day of their therapy. Additionally, the patients who received placebo (group P, N= 20) continued complaining for mualgias. The rest of the patients (group A, N= 190) did not experience any muscular symptoms, their laboratory tests showed elevation of liver enzymes and lipids and a decrease in car levels in the blood whereas a remarkable increase of car excretion was determined in their urine.ConclusionsIso therapy decreases car blood levels in patients with CA. l‐car supplementation might treat liver and muscular side effects of the drug. These hopeful preliminary results need further investigation.
Itraconazole and tèrbinafine in perspective: from petri dish to patient
Authors: De Doncker P. 
Published: September 2006

AbstractObjective To compare the antifungal activity of itraconazole and terbinafine in vitro and to relate them to their experimental in vivo activity and to their efficacy in patients with superficial fungal infections (tinea pedis and onychomycosis).Results Fungal infections such as onychomycosis and tinea pedis are often treated with oral antifungals. With the introduction of newer agents such as terbinafine and itraconazole, efficacy and safety have been improved. In vitro evaluation showed somewhat better results against dermatophytes for terbinafine than for itraconazole, but in vivo results were at least equivalent. Moreover, itraconazole is a broad‐spectrum agent with higher cure rates for infections other than dermatophytosis (e.g. for Candida infections) than terbinafine, according to ex vivo studies. A review of all published clinical trials, comparing the efficacy and safety of terbinafine and itraconazole in a meta‐analysis revealed similar and high cure rates (>70%) for both antifungal agents and similar adverse event profiles. Both treatments were safe and well tolerated.Conclusions Antifungal research has responded to the challenges of treating superficial infections by developing effective, well‐tolerated, fast‐acting antifungal therapies. The reduction in treatment duration has also led to improved patient's compliance. The most noticeable difference between itraconazole and terbinafine is the 1‐week pulse concept of itraconazole in contrast to the continuous treatment concept of terbinafine.
EEMCO guidance for the assessment of skin topography1
Authors: Lévêque J.L. 
Published: September 2006

AbstractNumerous factors can modify the visibility or the actual dimensions of the skin microrelief and wrinkles. To quantify these changes, several methods, including clinical and non‐invasive ones, have been proposed. This article reviews the advantages et drawbacks of all of them and lists some experimental recommendations to make the results of studies using these methods, more reliable.
Immunopathological examination of esophagus as a useful criterion of cure in pemphigus vulgaris
Authors: Torzecka Jolanta Dorota , Sysa‐Jedrzejowska Anna , Waszczykowska Elzbieta , Wozniacka Anna , Dziankowska‐Bartkowiak Bozena , Narbutt Joanna 
Published: September 2006

AbstractBackgroundWe performed histopathological and immunopathological examinations of the esophagus in patients with pemphigus vulgaris during clinical remission.MethodsIn the group of 14 patients without serum antibodies, five were treated with low doses of steroids and cyclophosphamide (as maintenance treatment), while nine had already completed the therapy.ResultsIn all five cases under maintenance treatment we found bound pemphigus antibodies in vivo. Acantholysis was present in two of these. In all nine non‐treated patients, acantholysis and immunopathological findings were negative.ConclusionsOur studies reveal that the absence of bound ‘pemphigus vulgaris’ antibodies in the esophagus by immunological examination could be regarded as proof of complete cure and could be the decisive finding to stop pemphigus treatment.
Serum level of sELAM‐1 in psoriatic patients correlates with disease activity
Authors: Krasowska Dorota , Pietrzak Aldona , Lecewicz‐Torun Barbara 
Published: September 2006

AbstractBackgroundEndothelial leucocyte adhesion molecule‐1 (ELAM‐1) acts as an adhesion ligand for neutrophils and monocytes and the expression of this molecule on the vascular endothelium may reflect its ability to recruit neutrophils from circulation. The next step is the transendothelial migration of neutrophils into lesional psoriatic skin. ELAM‐1 may also exist in a soluble form.MethodsWe determined the serum levels of ELAM‐1 by ELISA in 41 patients with psoriasis and 20 controls.ResultsPatients with acute psoriasis displayed higher levels of ELAM‐1 (85.45 ± 47.72 ng/ml) than controls (36.02 ± 15.60 ng/ml) and patients with chronic disease (61.24 ± 27.91 ng/ml). In 25 patients we measured the serum level of ELAM‐1 twice: at the beginning and after treatment of the disease and we did not find any significant changes. We also found a correlation between serum ELAM‐1 and PASI score.ConclusionsThese data suggest that there is a high serum level of E‐selectin in psoriatic subjects even after clearing of the disease. Serum E‐selectin may reflect the general activation of endothelial cells in the disease and may be a new sensitive marker of disease activity.
Watermelon‐stomach as a cause of chronic iron deficiency anemia in a patient with systemic sclerosis
Authors: Fábián György , Tóvári Eszter , Baranyay Ferenc , Czirják László 
Published: September 2006

AbstractWatermelon‐stomach is a rare cause of gastrointestinal bleeding. There has been an increasing number of reports on the association of this lesion with diseases of the scleroderma group, causing chronic, sometimes severe gastrointestinal blood loss. The present report presents the case of a 75‐year‐old female with limited cutaneous systemic sclerosis and watermelon‐stomach, which was the cause of her long‐standing sideropenic anemia.
Bockenheimer's syndrome
Authors: van Geest A.J. , Veraart J.C.J.M. , de Haan M. , Neumann H.A.M. 
Published: September 2006

AbstractA case of a very extensive form of the rare Bockenheimer's syndrome (genuine diffuse phlebectasia) in a 45‐year‐old female patient is presented. The subject presented phlebectasias of the upper right leg, the vulva and the right side of the abdomen. The diagnostic and therapeutic possibilities for cases of patients with Bockenheimer's syndrome are described.
Laugier‐Hunziker syndrome: case report and treatment with the Q‐switched Nd‐Yag laser
Authors: Ferreira Maria João Branco , Ferreira Ana Macedo , Soares A. Pinto , Rodrigues J.C. Fernandes 
Published: September 2006

AbstractWe report the case of a 46‐year‐old Caucasian female presenting with mucocutaneous pigmentation on the lips, oral mucosa, hands, feet and nails, as well as on a psoriatic plaque. She was successfully treated with Q‐switched Nd‐Yag laser, with double frequency, for both the mucosal and cutaneous lesions.
Management of androgenetic alopecia★
Authors: Tosti A. , Camaeho‐Martinez F. , Dawber R. 
Published: September 2006

AbstractBackgroundAndrogenetic alopecia (AGA) is the most frequent cause of hair loss affecting up to 50% of men and 40% of women by the age of 50.MethodsThis paper outlines the current status of diagnosis and offers guidelines for optimal management of AGA in both men and women.ResultsThe diagnosis of AGA can usually be confirmed by medical history and physical examination alone. A trichogram can be useful to assess the progression of the hair loss. A scalp biospy is diagnostic but usually not required. In women with signs of hyperandrogenism, investigation for ovarian (polycystic ovarian disease) or adrenal (late‐onset congenital adrenal hyperplasia) disorders is required. Mild to moderate AGA in men can be treated with oral finasteride or topical minoxidil. Oral finasteride at the dosage of 1 mg/day produced clinical improvement in up to 66% of patients treated for 2 years. The drug is effective for both frontal and vertex hair thinning. Medical treatment with finasteride or minoxidil should be continued indefinitely since interruption of therapy leads to hair loss with return to pretreatment status. Mild to moderate AGA in women can be treated with oral antiandrogens (cyproterone acetate, spironolactone) and/or topical minoxidil with good results in many cases. Hair systems and surgery may be considered for selected cases of severe AGA both in men and in women.ConclusionsPatients with AGA should be informed about the pathogenesis of the condition. If used correctly, available medical treatments arrest progression of the disease and reverse miniaturization in most patients with mild to moderate AGA.
Aneurysmal fibrous histiocytoma: an unusual variant of cutaneous fibrous histiocytoma
Authors: McKenna Dermot B. , Kavanagh Gina M. , McLaren Kathryn M. , Tidman Michael J. 
Published: September 2006

AbstractAneurysmal fibrous histiocytoma (AFH) (Santa‐Cruz DJ, Kyriakos M. Aneurysmal (‘Angiomatoid’) fibrous histiocytoma of the skin. Cancer 1981;47:2053–2061) is a distinct but poorly recognized clinicopathological variant of cutaneous fibrous histiocytoma (CFH) that may result from the slow extravasation of blood into the tumour. The resulting lesion can have a very different clinicopathological appearance resulting in diagnostic confusion. We describe a patient with an AFH that presented as a pigmented nodule on the foot and discuss clinical recognition and histological differentiation from other tumours.
Herpetic whitlow in an AIDS patient
Authors: García‐Plata M.D. , Moreno‐Giménez J.C. , García A. Vélez , Blanco F. Valverde , Roldán J.C. Fernandez 
Published: September 2006

AbstractThis case confirms that cutaneous herpes simplex virus (HSV) infections in many AIDS patients is important not only for the difficulty in diagnosis of herpetic lesions, but also for the possibility that co‐infection by HSV and HIV can adversely affect prognosis in these patients.
Subcutaneous fat necrosis of the newborn
Authors: Repiso‐Jiménez J.B. , Márquez J. , Sotillo I. , García‐Bravo B. , Camacho F. 
Published: September 2006

AbstractSubcutaneous fat necrosis of the newborn (SFN) is an uncommon disease that affects newborns who have suffered from tissue hypoxia during or following delivery. This disease appears during the first weeks of life. It consists of indurate, erythematous or purple‐erythematous nodules and plaques in the skin. Histology of a biopsy specimen shows granulomatous necrosis in the subcutis with radial crystals in lipocytes and giant cells. Spontaneous resolution in a few weeks is usual, but the mobilization of calcium from the necrosed subcutis together with the action of some hormones may cause hypercalcemia and certain serious complications. A newborn female child developed SFN after dystocic delivery causing cerebral frontal lobe hemorrhage. The skin nodules resolved spontaneously in a few weeks and no complications were observed 1 year later.
Immunohistochemical study of apoptosis markers and involvement of chemokine CXCR4 in skin Merkel cell carcinoma
Authors: Tucci MG , Lucarini G , Giangiacomi M , Zizzi A , Criante P , Ricotti G , Biagini G 
Published: September 2006

AbstractBackground  Merkel cell carcinoma (MCC) is a rare, aggressive cancer of the skin that mainly affects elderly patients. Because of its rarity, there is no established treatment or proven markers to guide therapy or prognosis. Immunohistochemical expression of apoptosis proteins is considered a useful marker of both malignancy and tumour progression. Apoptosis plays a fundamental role in skin homeostasis, and apoptotic cells have been detected in normal and diseased skin. Chemokines posses a wide range of biological activities and CXCR4 is expressed in some cancer cells, where it plays an efficient role in metastasis formation.Objective  To identify immunohistochemical parameters that can help clinicians select the most suitable therapy for skin MCC.Design  Antibodies against ki67, bcl‐2, p53, survivin, p16 and CXCR4 were tested to assess the usefulness of these antigens as indices of proliferation potential and predictors of prognosis.Methods  Immunohistochemical detection of apoptosis inhibitors and CXCR4 was performed on tissue from 12 patients with primary MCC. After excision of the primary lesion, five survived and had no metastases, and seven experienced local recurrence or lymph node metastases.Results  Expression of ki67 and survivin was increased in patients with local recurrence or metastasis (retrospectively classified as ‘poor prognosis’) compared with those with a ‘good prognosis’, and bcl‐2 expression was significantly greater (P = 0.003). P53 and p16 immunostaining was moderate in both groups. A positive correlation was observed between survivin and mutant p53 in the poor prognosis group (r = 0.593, P = 0.033; regression coefficient). High values of p53 were measured in patients with high levels of survivin and vice versa. CXCR4 was not detected at all.Conclusions  Our results show strong MCC cell apoptosis inhibition and a high cell proliferation capacity. The positive correlation between survivin and p53 may be a predictor of MCC spread via the lymphatic network. Absent CXCR4 expression may reflect a less aggressive form, with less efficient development of distant and non‐organ‐selective metastasis formation.
Dermatofibrosarcoma protuberans: a population‐based cancer registry descriptive study of 66 consecutive cases diagnosed between 1982 and 2002
Authors: Monnier D , Vidal C , Martin L , Danzon A , Pelletier F , Puzenat E , Algros MP , Blanc D , Laurent R , Humbert PH , Aubin F 
Published: September 2006

AbstractBackground  Dermatofibrosarcoma protuberans (DFSP) is a rare malignant tumour of the skin, with an estimated incidence of 0.8 to five cases per 1 million people per year.Objective  To study epidemiological, immunohistochemical and clinical features, delay in diagnosis, type of treatment and outcome of DFSP from 1982 to 2002.Methods  Using data from the population‐based cancer registry, 66 patients with pathologically proved DFSP were included (fibrosarcomatous DFSP were excluded). Each patient lived in one of the four departments of Franche‐Comté (overall population of 1 million people) at the time of diagnosis. The main data sources came from public and private pathology laboratories and medical records. The rules of the International Agency for Research on Cancer were applied.Results  The estimated incidence of DFSP in Franche‐Comté was about three new cases per 1 million people per year. Male patients were affected 1.2 times as often as female patients were. The trunk (45%) followed by the proximal extremities (38%) were the most frequent locations. DFSP occurred mainly in young adults between 20 and 39 years of age. Mean age at diagnosis was 43 years, and the mean delay in diagnosis was 10.08 years. Our 66 patients initially underwent a radical local excision. Among them, 27% experienced one or more local recurrences during 9.6 years of follow‐up. There was one regional lymph node recurrence without visceral metastases. These recurrences were significantly related to the initial peripheral resection margins. We observed a local recurrence rate of 47% for margins less than 3 cm, vs. only 7% for margins ranging from 3 to 5 cm [P = 0.004; OR = 0.229 (95%, CI = 0.103–0.510)]. The mean time to a first local recurrence was 2.65 years. Nevertheless, there was no death due to the DFSP course at the end of the follow‐up, and the final outcome was favourable.Conclusion  Our study emphasizes the importance of wide local excision with margins of at least 3 cm in order to prevent local recurrence. However, the recent development of inhibitors of signal transduction by the PDGFB pathway should soon modify the surgical strategy, which is often too mutilating.
Polymerase chain reaction detection of Clostridium perfringens in feces from captive and wild chimpanzees, Pan troglodytes
Authors: Fujita Shiho , Kageyama Takashi 
Published: September 2006

AbstractBackground  For veterinary management of non‐human primates in captivity, and conservation of wild‐living primates, management of their health risks is necessary. Incidences of pathogenic bacteria in the fecal specimens are considered as one of the useful indicators for non‐invasive health monitoring.Methods  We carried out the detection of Clostridium perfringens in feces from captive and wild chimpanzees by the rapid polymerase chain reaction method.Results  The bacterium was detected in most fecal specimens (80%) in captive chimpanzees. Contrarily, the detection rate in the wild chimpanzees was low, with 23% (n = 12) of 53 fecal samples from the Bossou group, Guinea, and 1.2% (1/81) in the Mahale group, Tanzania.Conclusions  These results show that the intestinal microflora differs between Pan populations under various living conditions, being influenced by their diet and environment.
Relationship between smoking status and periodontal conditions: findings from national databases in Japan
Authors: Ojima M. , Hanioka T. , Tanaka K. , Inoshita E. , Aoyama H. 
Published: September 2006

Background and Objective:  The association between cigarette smoking and periodontitis was examined employing two nationally representative samples of adults in Japan.Material and Methods:  Data were derived from the Survey of Dental Diseases (SDD) and the National Nutrition Survey (NNS) in 1999. In the SDD, periodontal conditions were evaluated by calibrated dentists utilizing the Community Periodontal Index (CPI), whereas in the NNS, participants were interviewed on the basis of smoking status by enumerators. Among 6805 records electronically linked via a household identification code, 4828 records of individuals aged 20 yr or older were analyzed.Results:  The prevalence of periodontal disease varied significantly by smoking status (p < 0.0001): 39.3%, 49.5% and 47.3% (CPI ≥ 3), and 7.9%, 11.7% and 12.4% (a more severe form of periodontitis, CPI = 4), for nonsmokers, former smokers and current smokers, respectively. In adults aged ≥ 40 yr (n = 3493), logistic regression models revealed greater probabilities (approximately 1.4 times higher) of periodontitis [CPI ≥ 3, odds ratio = 1.38 (1.12–1.71), p = 0.0024] and a more severe form of periodontitis [odds ratio = 1.40 (1.04–1.89), p = 0.0288] in current smokers compared with nonsmokers, following adjustment for possible confounding factors.Conclusion:  Based on the findings of this study and other numerous reports, cigarette smoking leads to deterioration of periodontal conditions in Japanese adults.
Transforming growth factor‐β3 affects plasminogen activator inhibitor‐1 expression in fetal mice and modulates fibroblast‐mediated collagen gel contraction
Authors: Li Wai‐Yee , Huang Eunice Y. , Dudas Marek , Kaartinen Vesa , Warburton David , Tuan Tai‐Lan 
Published: September 2006

ABSTRACTFor over two decades, the precise role of transforming growth factor‐β (TGF‐β) isoforms in scarless healing of mammalian fetal skin wounds has generated much interest. Although their exact role remains to be established, it has been suggested that high TGF‐β3 activity may correlate with a scarless phenotype. Previously, we showed that plasminogen activator inhibitor‐1 (PAI‐1), a known TGF‐β downstream molecule and marker of fibrosis, is also developmentally regulated during fetal skin development. In this study, the relationship between TGF‐β3 and PAI‐1 was investigated using embryonic day 14.5 TGF‐β3 knockout (ko) mice. The results showed increased PAI‐1 expression in the epidermis and dermis of ko mice, using an ex vivo limb‐wounding study. Furthermore, increased PAI‐1 expression and activity was seen in embryo extracts and conditioned media of ko dermal fibroblasts. When TGF‐β3 knockout fibroblasts were placed into three‐dimensional collagen matrices, they were found to have decreased collagen gel contraction, suggesting altered cell–matrix interaction. These findings provide a further avenue for the interactive role of TGF‐β3 and PAI‐1 during fetal scarless repair.