bluuebunny/crossref_metadata_2025_split huggingface dataset:
Argon laser peripheral iridoplasty for plateau iris associated with iridociliary cysts: a case report
Authors: Ang Ghee Soon , Bochmann Frank , Azuara-Blanco Augusto 
Published: January 2009

Abstract

Introduction
Plateau iris is recognised as an important cause of primary angle closure glaucoma. The management of this condition generally comprises laser peripheral iridotomy and iridoplasty, to remove any component of relative pupillary block and to widen the iridotrabecular drainage angle respectively. However, plateau iris may be associated with multiple iris cysts at the iridociliary junction, which then presents diagnostic and management problems.

Case presentation
We present a fifty-three year old Caucasian gentleman with plateau iris associated with peripheral iris cysts, in which the iridotrabecular angle did not widen despite having had both laser peripheral iridotomy and iridoplasty. The patient has remained asymptomatic over 12 months, and is under close follow-up to monitor for signs of glaucoma.

Conclusion
Plateau iris with iridociliary cysts can be difficult to diagnose and manage. Ultrasound biomicroscopy should be performed on patients with appositional iridotrabecular angle closure on gonioscopy, especially if the angle closure is not relieved with either laser peripheral iridotomy or iridoplasty. Question marks can be raised as to the benefit of laser iridotomy when plateau iris without pupillary block has already been conclusively diagnosed on ultrasound biomicroscopy.
Effects of Carbamide Peroxide on the Staining Susceptibility of Tooth-colored Restorative Materials
Authors: Yu H. , Pan X. , Lin Y. , Li Q. , Hussain M. , Wang Y. 
Published: January 2009

Clinical Relevance
The staining susceptibility of esthetic restorative materials is significantly affected by the use of 15% carbamide peroxide. The effects of bleaching on the surface morphology and color of restorative materials are material dependent.
Dosimetric investigation of dual energy photon beams with assymmetric collimator jaws
Authors: Varatharaj C. , Ravikumar M. , Supe Sanjay , Sathiyan S. , Ganesh K. , Arunkumar T. 
Published: January 2009

Dosimetric investigation of dual energy photon beams with assymmetric collimator jaws
Many modern linear accelerators are equipped with asymmetric collimators or jaws that can be moved independently. Asymmetric jaws have got many clinical applications in radiation therapy. In the present study, the dosimetric characteristics of asymmetric collimators from our linear accelerator with 6 and 18 MV X-rays were carried out. The field size factors (FSF) and half value layer (HVL) were measured in a water phantom using 0.6 cc Farmer chamber for symmetric and asymmetric fields for both 6 and 18 MV X-rays. Measurements of beam penumbra, percentage depth dose (PDD), cross beam profiles and calculated isodose curves were measured by RFA 300 for both asymmetric and symmetric fields. The FSF were found to agree with in 3% for symmetric and asymmetric fields. The HVL in water was found to be 15.8 cm and 14.4 cm for 6 MV photons and 26 cm and 22.9 cm for 18 MV photons at the central axis and at 20 cm off the central axis. At 30 cm depth the percentage depth dose for symmetric and asymmetric fields were found to differ as high as 6% for 6 MV and 4% for 18 MV fields. No observable difference in penumbra was noticed for symmetric and asymmetric fields of same dimensions. The constrictions of isodose curves at the edge nearer to central axis were noticed for asymmetrically placed fields. The observed differences could be due to the passage of primary beam through differential thickness of the flattening filter which alters the beam quality.
The Good Life, The Examined Life, and the Embodied Life
Authors: Shusterman Richard 
Published: January 2009

The Good Life, The Examined Life, and the Embodied Life
The good life and the examined life have long been advocated as key philosophical goals, and they have often been closely linked together. My paper critically examines this linkage by considering arguments both for and against the value of self-examination for achieving the good life. Because somatic self-examination has been viewed as especially problematic for the philosophical project of achieving the good life, this form of self-examination will be given special attention in the paper, and its discussion will be situated within the larger issue of the extent to which the embodied life is central to the good life.
Effect of Perforated Film And Polypropylene Nonwoven Covering On The Marketable Value of Early Potato Yield
Authors: Wadas Wanda , Kosterna Edyta , Sawicki Marek 
Published: January 2009

Effect of Perforated Film And Polypropylene Nonwoven Covering On The Marketable Value of Early Potato Yield
The effect of cover material (perforated polyethylene film, polypropylene nonwoven) and date of its removal (2 and 3 weeks after plant emergence) on the marketable value of the yield of early potato cultivar (Aksamitka, Cykada) was investigated. Potatoes were harvested 60 and 75 days after planting, in the second and third decade of June. Plant vegetation forcing by covering resulted in an increase in the marketable tuber yield (diameter >30 mm) and improved marketable value due to a reduced share of small tubers, with the diameter of 31-40 mm, especially at a very early date of potato harvest. In potato cultivation for very early crop, the cover material had a greater effect on the tuber yield and its marketable value than the length of plant covering period. Perforated film was a better kind of cover than polypropylene nonwoven, especially in the year with cold spring. At the delayed date of potato harvest the marketable tuber yield depended, to a higher degree on the date of cover removal. Higher yield was obtained when the cover was removed 2 weeks after plant emergence.
Length of Human Vermiform Appendix in Bangladeshi People
Authors: Rahman Md Mahbubur , Khalil Mohsin , Khalil Mansur , Hussain Anwar , Rahman Habibur Rahman , Mannan Sabina , Sultana Seheli Zannat , Ahamed M Shibbir 
Published: January 2009

The study was done to find out the length of human vermiform appendix in Bangladeshi people to magnify the knowledge regarding the diverse length of human vermiform appendix in our population. A total 100 vermiform appendix were measured with different age and sex during routine postmortem examination in the autopsy laboratory of forensic medicine department of Mymensingh Medical College. This cross sectional study was done by convenient sampling technique. For convenience of differentiating the length of vermiform appendix in relation to different age and sex, findings were classified in four groups (up to 20 years, 21 to 35 years, 36 to 55 years and 56 to 70 years). Length of vermiform appendix was 2.6 cm to 14 cm. Mean length was 7.9 cm in female and 7.56 cm in male. The highest mean length of vermiform appendix in group A was 9.17 cm and lowest was 5.93 cm in group D. Key words: Human Vermiform Appendix; Length; Bangladesh DOI:10.3329/jbsp.v2i0.977 J Bangladesh Soc Physiol. 2007 Dec;(2): 13-16
Mass of the Vermiform Appendix in Bangladeshi People
Authors: Rahman M Mahbubur , Khalil Mohsin , Khalil Mansur , Jahan Mst Khurshida , Shafiquazzaman M , Parvin Bilkis 
Published: January 2009

This study was done to measure the weight of vermiform appendix in Bangladeshi people to augment the data regarding variational anatomy in our setting. A total 100 vermiform appendix (male - 60, female - 40) were excised from cadaver of different age and sex during routine post mortem examination in the autopsy laboratory of Forensic Medicine Department of Mymensingh Medical College. This cross-sectional study was done by convenient sampling technique. The weight depended on length and thickness. The weight decreases gradually with advancing age probably decreasing number of lymphatic follicle and that replaced by connective tissue. Lymphatic follicles were examined and estimated by microscope. For convenience of differentiating the weight of vermiform appendix in relation to age and sex, specimens were categorized in four age groups (up to 20 year, 21 - 35 years, 36 - 55 years, 56 - 70 years). Mean weight of vermiform appendix was maximum in group - B (4.07 Â± SE 0.82 gm) and minimum in group D (3.01 Â± SE 0.74 gm). The weight range was from 2 gm (group - D) to 5.50 gm (group - B). Diameter of lymphatic follicle was largest 43.08 micrometer in group-A, and least diameter was 3.08 micrometer in group - D. The range of number of lymphatic follicle was 1 to 6. Mean number of lymphatic follicle in male was 4.48 & in female were 5.40. Key Words: Human Vermiform, Appendix, Weight, Lymphatic, Follicle Â doi: 10.3329/jbsp.v3i0.1787 J Bangladesh Soc Physiol.2008 Dec;(3):8-12.
Evaluation of Parasympathetic Nerve Function Status in Healthy Elderly Subjects
Authors: Islam T , Begum N , Begum S , Ferdousi S , Ali T 
Published: January 2009

Background: Autonomic control on cardiovascular activity is modified with age. Impaired autonomic nerve functions are common features of patients suffering from cardiovascular diseases particularly in old age. Objective: To observe the influence of aging process on parasympathetic nerve function. Study design: This observational study was conducted in the Department of Physiology, BSMMU, Dhaka during the period of July 2005 to June 2006. For this purpose, 60 apparently healthy elderly subjects of both sexes were selected as study group and divided into two groups-one group consisted of 30 elderly subjects with age ranged from 51-60 years and another group consisted of 30 elderly subjects with age ranged from 61-70 years. Thirty sex and BMI matched healthy adults with age ranged from 21-30 years were studied as control. Methods: Parasympathetic nerve function status of all the subjects were assessed by three simple non-invasive cardiovascular reflex tests. These were heart rate response to valsalva maneuver, heart rate response to deep breathing and heart rate response to standing (30th:15th ). For statistical analysis one way ANOVA (Post Hoc Test) and the Pearson's correlation co-efficient tests were done. Results: Mean (Â± SD) of valsalva ratio were 1.50Â±0.23, 1.32Â±0.14 and 1.28Â±0.15; HR response to deep breathing test were 25.36Â±3.90, 18.82Â±3.35 and 15.96Â±3.54 beats/min; 30th:15th ratio in standing test were 1.100.06, 1.05Â±0.03 and 1.04Â±0.02 in 21- 30, 51-60 and 61-70 years age groups respectively. All the 3 parameters were significantly lower in both elderly groups compared to that of control adults (p < 0.001) Again, HR response to deep breathing was significantly lower in 61-70 years age group compared to that of 51-60 years age group. Valsalva ratio and 30th:15th ratio were also lower in 61-70 years age group than that of 51-60 years group but the differences were not statistically significant. All the 3 parameters were negatively correlated with age which were statistically significant. Conclusion: From this study it may concluded that aging process substantially impaired cardiovascular parasympathetic nerve functions. Key words: Cardiovascular reflex test, elderly person. Â Â Â Â Â doi: 10.3329/jbsp.v3i0.1790 J Bangladesh Soc Physiol.2008 Dec;(3):23-28.
Parasympathetic Nerve Functions in Type 2 Diabetes Mellitus: Relation to Glycemic Status and Duration of Diabetes
Authors: Alam Md Khairul , Begum Noorzahan , Begum Selina 
Published: January 2009

Background: Cardiovascular autonomic dysfunction is associated with higher mortality and is a common health problem observed in diabetic patients. Early detection of autonomic dysfunction in diabetic patient is important for prevention of this complication. Objectives: The study has been designed to observe the parasympathetic nerve function status in type 2 diabetic subjects in order to assess the relationship between glycemic status and duration of diabetes and the parasympathetic nerve function. Study Design: This cross section study was carried out in the Department of Physiology, Bangabhandhu Sheikh Mujib Medical University, Dhaka, Bangladesh. Forty seven type 2 diabetic subjects were included in two groups. Group B consisted of 25 recently diagnosed diabetic subjects aged 40-68 years and group C consisted of 22 subjects having duration of diabetes for 10 - 20 years. Twenty five (25) age and BMI matched healthy subjects were included in group A (non diabetic) for control. Methods: Parasympathetic nerve functions were assessed by three simple non invasive cardiovascular reflex tests. These were Valsalva maneuver, Heart rate variation (HRV) to deep breathing, HRV to standing up. Glycemic status was assessed by serum glycosylated hemoglobin (HbA1C) and fasting plasma glucose (FPG). Data were analyzed by ât' test, Pearson's correlation coefficient. Results: Valsalva ratio was significantly lower in group C than that of group A but no significant difference was observed between group B & A and also between B and C. HRV in deep breathing and 30th:15th ratios were significantly lower in both the diabetic groups B and C than those of group A but these values were semilar in group B and C. Values of correlation of fasting plasma glucose with valsalva ratio, HRV in deep breathing and 30th:15th ratios in standing test in all three groups were not statistically significant. But correlation of duration of diabeties with valsalva ratio was stastically significant but with RHV in deep breathing and 30th:15th ratios were not significant. Conclusion: From this study it may be concluded that there was progressive deterioration of parasympathetic function with increase in duration of diabetes in patients suffering from type 2 diabetes. Key Words: Parasympathetic, Nerve, Diabetes, Neuropathy Â doi: 10.3329/jbsp.v3i0.1793 Â J Bangladesh Soc Physiol.2008 Dec;(3):42-49.
Engineering of the yeast antioxidant enzyme Mpr1 for enhanced activity and stability
Authors: Iinoya Kaoru , Kotani Tetsuya , Sasano Yu , Takagi Hiroshi 
Published: January 2009

AbstractThe budding yeast Saccharomyces cerevisiae Σ1278b has the MPR1 gene, which confers resistance to the proline analogue azetidine‐2‐carboxylate (AZC). This gene encodes an N‐acetyltransferase Mpr1 that detoxifies AZC, and the homologous genes have been found in many yeasts. Recently, we found that Mpr1 protects yeast cells by reducing the intracellular reactive oxygen species (ROS) levels under oxidative stresses, such as heat‐shock, freezing, or ethanol treatment. Unlike the known antioxidant enzymes, Mpr1 is thought to acetylate toxic metabolite(s) involved in ROS generation via oxidative events. To improve the enzymatic functions of Mpr1, we applied PCR random mutagenesis to MPR1. The mutagenized plasmid library was introduced into the S. cerevisiae S288C strain lacking MPR1, and we successfully isolated two Mpr1 variants with higher AZC resistance (K63R and F65L/L117V). Interestingly, overexpression of the K63R variant was found to increase cell viability or decrease intracellular ROS levels after exposure to H2O2 or ethanol compared with the wild‐type Mpr1. In vitro studies with the recombinant enzymes showed that the catalytic efficiency of the K63R variant for AZC and acetyl‐CoA was higher than that of the wild‐type Mpr1 and that the F65L mutation greatly enhanced the thermal stability. The mutational analysis and molecular modeling suggest that an α‐helix containing Lys63 and Phe65 has important roles in the function of Mpr1. In addition, the wild‐type and K63R variant Mpr1 reduced intracellular ROS levels under ethanol stress conditions on haploid sake yeast cells. These results suggest that engineering Mpr1 might be useful in breeding oxidative stress‐tolerant yeast strains. Biotechnol. Bioeng. 2009;103: 341–352. © 2009 Wiley Periodicals, Inc.
Image guided medialization laryngoplasty
Authors: Jin Ge , Baek Nakhoon , Hahn James K. , Bielamowicz Steven , Mittal Rajat , Walsh Raymond 
Published: January 2009

AbstractTechniques that originate in computer graphics and computer vision have found prominent applications in the medical domain. In this paper, we have seamlessly developed techniques from computer graphics and computer vision together with domain knowledge from medicine to develop an image guided surgical system for medialization laryngoplasty. The technical focus of this paper is to register the preoperative radiological data to the intraoperative anatomical structure of the patient. With careful analysis of the real‐world surgical environment, we have developed an ICP‐based partial shape matching algorithm to register the partially visible anatomical structure to the preoperative CT data. We extracted distinguishable features from the human thyroid cartilage surface and applied image space template matching to find the initial guess for the shape matching. The experimental result shows that our feature‐based partial shape matching method has better performance and robustness compared with original ICP‐based shape matching method. Although this paper concentrates on the medialization laryngoplasty procedure, its generality makes our methods ideal for future applications in other image guided surgical areas. Copyright © 2009 John Wiley & Sons, Ltd.
Two genetic pathways, t(1;10) and amplification of 3p11–12, in myxoinflammatory fibroblastic sarcoma, haemosiderotic fibrolipomatous tumour, and morphologically similar lesions
Authors: Hallor Karolin H , Sciot Raf , Staaf Johan , Heidenblad Markus , Rydholm Anders , Bauer Henrik CF , Åström Kristina , Domanski Henryk A , Meis Jeanne M , Kindblom Lars‐Gunnar , Panagopoulos Ioannis , Mandahl Nils , Mertens Fredrik 
Published: January 2009

AbstractMyxoinflammatory fibroblastic sarcoma (MIFS) is a low‐grade malignant neoplasm for which limited genetic information, including a t(1;10)(p22;q24) and amplification of chromosome 3 material, is available. To further characterize these aberrations, we have investigated eight soft tissue sarcomas diagnosed as MIFS, haemosiderotic fibrolipomatous tumour (HFT), myxoid spindle cell/pleomorphic sarcoma with MIFS features, and inflammatory malignant fibrous histiocytoma/undifferentiated pleomorphic sarcoma with prominent inflammation (IMFH) harbouring a t(1;10) or variants thereof and/or ring chromosomes with possible involvement of chromosome 3. Using chromosome banding, fluorescencein situhybridization, array‐based comparative genomic hybridization, global gene expression, and real‐time quantitative PCR analyses, we identified the breakpoint regions on chromosomes 1 and 10, demonstrated and delineated the commonly amplified region on chromosome 3, and assessed the consequences of these alterations for gene expression. The breakpoints in the t(1;10) mapped toTGFBR3in 1p22 and in or nearMGEA5in 10q24, resulting in transcriptional up‐regulation ofNPM3and particularlyFGF8, two consecutive genes located close toMGEA5. The ring chromosomes contained a commonly amplified 1.44 Mb region in 3p11–12, which was associated with increased expression ofVGLL3andCHMP2B. The identified genetic aberrations were not confined to MIFS; an identical t(1;10) was also found in a case of HFT and the amplicon in 3p was seen in an IMFH. Copyright © 2009 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Beta‐catenin status in paediatric medulloblastomas: correlation of immunohistochemical expression with mutational status, genetic profiles, and clinical characteristics
Authors: Fattet Sarah , Haberler Christine , Legoix Patricia , Varlet Pascale , Lellouch‐Tubiana Arielle , Lair Severine , Manie Elodie , Raquin Marie‐Anne , Bours Danielle , Carpentier Sabrina , Barillot Emmanuel , Grill Jacques , Doz Francois , Puget Stephanie , Janoueix‐Lerosey Isabelle , Delattre Olivier 
Published: January 2009

AbstractMedulloblastoma is the most frequent malignant paediatric brain tumour. The activation of the Wnt/β‐catenin pathway occurs in 10‐15% of medulloblastomas and has been recently described as a marker for favourable patient outcome. We report a series of 72 paediatric medulloblastomas evaluated for β‐catenin protein expression, CTNNB1 mutations, and comparative genomic hybridization. Gene expression profiles were also available in a subset of 40 cases. Immunostaining of β‐catenin showed extensive nuclear staining (>50% of the tumour cells) in six cases and focal nuclear staining (<10% of cells) in three cases. The other cases either exhibited a signal strictly limited to the cytoplasm (58 cases) or were negative (five cases). CTNNB1 mutations were detected in all β‐catenin extensively nucleopositive cases. The expression profiles of these cases documented strong activation of the Wnt/β‐catenin pathway. Remarkably, five out of these six tumours showed a complete loss of chromosome 6. In contrast, cases with focal nuclear β‐catenin staining, as well as tumours with negative or cytoplasmic staining, never demonstrated CTNNB1 mutation, Wnt/β‐catenin pathway activation or chromosome 6 loss. Patients with extensive nuclear staining were significantly older at diagnosis and were in continuous complete remission after a mean follow‐up of 75.7 months (range 27.5–121.2 months) from diagnosis. All three patients with focal nuclear staining of β‐catenin died within 36 months from diagnosis. Altogether, these data confirm and extend previous observations that CTNNB1‐mutated tumours represent a distinct molecular subgroup of medulloblastomas with favourable outcome, indicating that therapy de‐escalation should be considered. International consensus on the definition criteria of this distinct medulloblastoma subgroup should be achieved. Copyright © 2009 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Determinants of response to epidermal growth factor receptor tyrosine kinase inhibition in squamous cell carcinoma of the head and neck
Authors: Rogers Susanne J , Box Carol , Chambers Philip , Barbachano Yolanda , Nutting Christopher M , Rhŷs‐Evans Peter , Workman Paul , Harrington Kevin J , Eccles Suzanne A 
Published: January 2009

AbstractDramatic responses to epidermal growth factor receptor (EGFR) tyrosine kinase (TK) inhibitors may be seen in non‐small cell lung cancers (NSCLCs) with a sensitizing mutation of the EGFR TK domain. It is not known how to predict response in patients with squamous cell carcinoma of the head and neck (SCCHN), where EGFR TK mutations are less frequent and where response rates in unselected patients are disappointing. We have characterized the intrinsic sensitivity of a panel of 18 SCCHN cell lines to gefitinib, an EGFR TK inhibitor, and have investigated correlations between putative markers of response and intrinsic sensitivity. Induction of G1 arrest was only seen in cell lines with GI50 < 1 µM. Expression of EGFR, by three techniques, correlated with sensitivity to gefitinib. ERB‐B2 expression appeared to influence sensitivity to gefitinib but ERB‐B3 expression did not. While EGFR tyrosine kinase mutations were not detected, EGFR gene amplification was confirmed by fluorescence in situ hybridization in the most sensitive cell line. The number of cytosine adenine dinucleotide repeats in intron 1 of the EGFR gene did not correlate with sensitivity. E‐cadherin expression was detected in cell lines with a range of sensitivities, whereas amphiregulin was secreted predominantly by sensitive cell lines. MET expression was an independent predictor of sensitivity to gefitinib, although neither expression nor phosphorylation of insulin‐like growth factor 1 receptor correlated with intrinsic resistance. Breast receptor kinase (BRK) was more highly expressed in the sensitive cell lines, but siRNA knockdown of neither BRK nor MET affected sensitivity. Our data suggest that overexpression of EGFR and multiple related cell surface receptors may be associated with sensitivity to gefitinib and that differences between our data and the literature highlight that biomarkers of response are tumour type‐ and cell line‐dependent. Copyright © 2009 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.