bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving therapeutic potential in breast cancer via histone deacetylase inhibitor loaded nanofibrils
Authors: Senthilkumar Praveetha , Gogoi Bhaskar , Dhan Swati Smita , Subramani Ramesh , Pushparaj Charumathi , Mahesh Ayyavu 
Published: March 2024

AbstractEpigenetic modifications play a significant role in cancer progression, making them potential targets for therapy. Histone deacetylase inhibitors have shown promise in inhibiting cancer cell growth, including in breast cancer (BC). In this research, we examined the potential of using suberoyl anilide hydroxamic acid (SAHA)‐loaded β‐lg nanofibrils as a drug delivery system for triple‐negative BC cell lines. We assessed their impact on cell cycle progression, apoptosis, levels of reactive oxygen species, and mitochondrial membrane potential in cancer cells. The combination of SAHA and β‐lg nanofibrils demonstrated enhanced efficacy in inhibiting cell growth, inducing cell cycle arrest, and promoting apoptosis (43.78%) compared to SAHA alone (40.09%). Moreover, it effectively targeted cancer cells without promoting drug resistance while using a low concentration of the nanofibrils. These findings underscore the promising potential of nanofibril‐based drug delivery systems for BC treatment.
A rare case of resection of a mucinous cystic neoplasm originating from the extrahepatic bile duct with cholangioscopic imaging
Authors: Masaki Yoshiharu , Kawakami Yujiro , Ishigami Keisuke , Murota Ayako , Shitani Masahiro , Kukita Kazuharu , Kimura Yasutoshi , Segawa Keiko , Hasegawa Tadashi , Nakase Hiroshi 
Published: March 2024

AbstractA 29‐year‐old woman was admitted to our hospital for examination of obstructive jaundice and an extrahepatic bile duct lesion. Contrast‐enhanced computed tomography revealed a 20 mm cystic lesion with a thin external capsule in the common hepatic duct. Cholangioscopy revealed translucent oval masses with capillary vessels attached to the bile duct walls. The surface was mostly smooth yet partially irregular with redness, suggesting that the masses were epithelial neoplasms. Histological findings of cholangioscopy‐guided targeted biopsies of the mass showed subepithelial spindle cell proliferation with no atypical epithelium. The patient underwent an extrahepatic bile duct resection to confirm the pathological diagnosis. Immunohistochemistry of surgical specimens revealed that the spindle cells were positive for estrogen and progesterone receptors. Finally, the cystic lesion with ovarian‐like stroma was diagnosed as a mucinous cystic neoplasm with low‐grade intraepithelial neoplasia. This is the first report of cholangioscopic imaging of a biliary mucinous cyctic neoplasm. Cholangioscopic imaging can be helpful in the differential diagnosis of biliary neoplasms and in the determination of treatment strategies.
Advances and efficacy in specimen handling for endoscopic ultrasound‐guided fine needle aspiration and biopsy: A comprehensive review
Authors: Iwashita Takuji , Uemura Shinya , Ryuichi Tezuka , Senju Akihiko , Iwata Shota , Ohashi Yosuke , Shimizu Masahito 
Published: March 2024

AbstractEndoscopic ultrasound‐guided fine needle aspiration and biopsy have significantly evolved since they offer a minimally invasive approach for obtaining pathological specimens from lesions adjacent to or within the intestine. This paper reviews advancements in endoscopic ultrasound‐guided fine needle aspiration and biopsy techniques and devices, emphasizing the importance of handling specimens for diagnostic accuracy. Innovations of fine needle biopsy needles with features like side holes and Franseen shapes have enhanced histological sampling capabilities. Techniques for specimen handling, including rapid on‐site evaluation and macroscopic on‐site evaluation, play pivotal roles in assessing sample adequacy, thereby influencing diagnostic outcomes. The utility of artificial intelligence in augmenting rapid on‐site evaluation and macroscopic on‐site evaluation, although still in experimental stages, presents a promising avenue for improving procedural efficiency and diagnostic precision. The choice of specimen handling technique is dependent on various factors including endoscopist preference, procedure objectives, and available resources, underscoring the need for a comprehensive understanding of each method's characteristics to optimize diagnostic efficacy and procedural safety.
Performance‐enhancing substances in sport: A scientometric review of 75 years of research
Authors: Carollo Alessandro , Corazza Ornella , Mantovani Maria , Silvestrini Nicolò , Rabin Olivier , Esposito Gianluca 
Published: March 2024

AbstractThe use of performance‐enhancing substances not only undermines the core values of sports but also poses significant health risks to athletes. In a fast‐evolving doping environment, where sport professionals are constantly seeking novel and illegal means to bypass doping tests, and new substances are regularly detected on the drug market, it is crucial to inform authorities with updated evidence emerging from scientific research. The current study aims to (i) outline the structure of knowledge in the literature on performance enhancers in sports (i.e., most active countries, main sources, most productive authors, and most frequently used keywords); (ii) identify the most impactful documents in the field; and (iii) uncover the main domains of research in the literature. To do so, we conducted a comprehensive scientometric analysis of the literature on doping, sourcing our data from Scopus. Our research involved a document co‐citation analysis of 193,076 references, leading to the identification of the 51 most influential documents and seven key thematic areas within the doping literature. Our results indicate that the scientific community has extensively studied the most prevalent doping classes, such as anabolic agents and peptide hormones, and little is still known about the use of contaminated supplements or other types of enhancers identified as emergent trends. Concurrently, technological advancements contributed to the development of more sophisticated doping detection techniques, using blood or urine samples. More recently, the focus has shifted towards the athlete biological passport, with research efforts aimed at identifying biomarkers indicative of doping. The dynamic nature of doping methods underlines the necessity for more robust educational campaigns, aiming at raising awareness among sports professionals and their entourage about the dangers of doping and the intricacies of its control mechanisms.
Deficits in olfactory system neurogenesis in neurodevelopmental disorders
Authors: Sweat Sean C. , Cheetham Claire E. J. 
Published: March 2024

SummaryThe role of neurogenesis in neurodevelopmental disorders (NDDs) merits much attention. The complex process by which stem cells produce daughter cells that in turn differentiate into neurons, migrate various distances, and form synaptic connections that are then refined by neuronal activity or experience is integral to the development of the nervous system. Given the continued postnatal neurogenesis that occurs in the mammalian olfactory system, it provides an ideal model for understanding how disruptions in distinct stages of neurogenesis contribute to the pathophysiology of various NDDs. This review summarizes and discusses what is currently known about the disruption of neurogenesis within the olfactory system as it pertains to attention‐deficit/hyperactivity disorder, autism spectrum disorder, Down syndrome, Fragile X syndrome, and Rett syndrome. Studies included in this review used either human subjects, mouse models, or Drosophila models, and lay a compelling foundation for continued investigation of NDDs by utilizing the olfactory system.
Examining co‐occurring social anxiety in cognitive behavioral therapy for eating disorders: Does it change and does it moderate eating disorder outcomes?
Authors: Ho Pheobe L. , Erceg‐Hurn David M. , McEvoy Peter M. , Campbell Bruce N. C. , Mathersul Danielle C. , Correia Helen M. , Raykos Bronwyn C. 
Published: March 2024

AbstractObjectiveEating disorders (EDs) often co‐occur with social anxiety disorder (SAD). However, little research has examined the influence of SAD symptoms on ED treatment outcomes in the context of individual outpatient cognitive‐behavior therapy for eating disorders (CBT‐ED). It is plausible that SAD symptom severity could improve as a result of ED treatment, given the high overlap between EDs and SAD. We sought to test whether baseline SAD symptoms moderate early response to CBT‐ED or post‐treatment outcomes in CBT‐ED, and the degree to which SAD symptoms improve during therapy despite SAD not being an explicit treatment target.MethodED clients (N = 226) aged ≥16 years were treated with CBT‐ED. Outcomes were ED symptoms, clinical impairment, and SAD symptoms measured at baseline, session 5 and post‐treatment.ResultsBaseline SAD was a weak moderator of early and post‐treatment ED symptoms and impairment. SAD symptoms improved moderately over treatment among clients who started with elevated levels of SAD symptomology.DiscussionClients with EDs can experience good therapeutic outcomes regardless of their social anxiety severity at pre‐treatment. SAD symptoms reduced over CBT‐ED, but protocol enhancements such as exposure‐based strategies that directly target co‐occurring social‐evaluative concerns may help achieve larger reductions in SAD symptoms.Public significanceEating disorders often co‐occur with anxiety disorders such as social anxiety. We found people who had both social anxiety and an eating disorder benefited as much from eating disorder treatment as people who did not have social anxiety. People who were socially anxious became less anxious as a by‐product of receiving eating disorder treatment. It may be possible to reduce social anxiety further by enhancing eating disorder treatment protocols.
First documented movement of a humpback whale between the Cape Verde Islands and West Greenland
Authors: Chosson Valerie , Wyss Virginie , Jann Beatrice , Wenzel Frederick W. , Sigurðsson Guðjón Már , Simon Malene , Hansen Rikke Guldborg , Jones Lindsey S. 
Published: March 2024

AbstractThe endangered population of humpback whales (Megaptera novaeangliae) breeding and calving off the Cape Verde Islands (CVI) are known to migrate to feeding areas located along the eastern margin of the North Atlantic Ocean (Iceland, and Norway). Here, we report for the first time a confirmed migration of an individual humpback whale from CVI breeding ground to a western North Atlantic feeding ground of West Greenland. This individual humpback, which was photographed and identified off the coast of West Greenland in 2021, was previously documented in CVI 22 years before (1999). An annual subsistence hunt for humpbacks occurs in West Greenland and the resighting at this location with a humpback whale from CVI has strong implications for the conservation efforts of the small CVI population.
δ2H isotopic offsets in xylem water measurements under cryogenic vacuum distillation: Quantifying and correcting wood‐water hydrogen exchange influences
Authors: Younger Seth E. , Blake John , Jackson C. Rhett , Aubrey Doug P. 
Published: March 2024

AbstractStable isotopes δ18O and δ2H are used to infer vegetation water sources. In some studies, significant xylem water δ2H offsets from potential source waters have been observed. The offsets appear to be more prevalent with cryogenic vacuum distillation (CVD) of plant water. Hypothesized mechanisms for these offsets include changes during plant water uptake and transport, and methodological problems. We propose that a large portion of the offsets are due to hydrogen isotope exchange between xylem water and non‐crystalline hydroxyl groups of wood cellulose and hemicellulose during CVD. We present a method for estimating the hypothesized isotopic exchange between wood tissues and water, which is the result of Rayleigh and equilibrium fractionation. To estimate the exchange, we use published wood properties for North American tree species and isotope chemical relationships as a function of moisture content, CVD temperature and water extraction efficiency. A simple model of exchange between xylem water and hydroxyl groups captures the range of observations in studies in which CVD and non‐CVD methods were compared. To evaluate the model, we compared observed δ2H offsets (sw‐excess) values from two field datasets (90°C, n = 364, and 170°C, n = 43) to δ2H offsets estimated with our chemical model. We found good agreement between observed and estimated δ2H offsets for samples extracted at 90°C (r2 = 0.69) but not for samples extracted at 170°C (r2 = 0.20). The offset may be eliminated by increasing the extraction temperature to 229°C or by adding a standard sufficient to raise the moisture content to >150%. A correction can also be approximated by applying a theoretical calculation based on the extraction temperature, moisture content and water extraction efficiency.
Akebia fruit: A review on its extraction, phytochemicals, bioactivities and applications
Authors: Li Yanhui , Yang Zongqi , Jin Chengyong , Liu Ye , Zhang Yu , Ma Xin , Song Wei , Cai Rui , Feng Kewei , Zhao Wanni , Yuan Yahong , Yue Tianli , Sheng Qinglin 
Published: March 2024

AbstractAkebia fruit is a plant used for both medicinal and edible purposes. In recent years, due to the rich phytochemical composition with bioactive effects, Akebia fruit has attracted increasing attention on its composition analysis, active ingredients identification, and product applications. For example, the protein, sugar, amino acids, and vitamin C content of the pulp is higher than that of ordinary fruit. The seeds are not only processed into edible oil, it is also rich in protein and have the potential to be developed into a new resource with beneficial effects on human health. However, the research on the understanding of Akebia as a plant fruit is relatively lacking. In this review, an overview of Akebia fruit from food perspectives, including extraction methods and phytochemicals, bioactive functions, and various applications, were summarized. Finally, based on the current status and existing challenges, the prospect and future development direction of Akebia fruit were discussed.
Obesity: the perfect storm for heart failure
Authors: Lembo Maria , Strisciuglio Teresa , Fonderico Celeste , Mancusi Costantino , Izzo Raffaele , Trimarco Valentina , Bellis Alessandro , Barbato Emanuele , Esposito Giovanni , Morisco Carmine , Rubattu Speranza 
Published: March 2024

AbstractObesity condition causes morphological and functional alterations involving the cardiovascular system. These can represent the substrates for different cardiovascular diseases, such as atrial fibrillation, coronary artery disease, sudden cardiac death, and heart failure (HF) with both preserved ejection fraction (EF) and reduced EF. Different pathogenetic mechanisms may help to explain the association between obesity and HF including left ventricular remodelling and epicardial fat accumulation, endothelial dysfunction, and coronary microvascular dysfunction. Multi‐imaging modalities are required for appropriate recognition of subclinical systolic dysfunction typically associated with obesity, with echocardiography being the most cost‐effective technique. Therapeutic approach in patients with obesity and HF is challenging, particularly regarding patients with preserved EF in which few strategies with high level of evidence are available. Weight loss is of extreme importance in patients with obesity and HF, being a primary therapeutic intervention. Sodium–glucose co‐transporter‐2 inhibitors have been recently introduced as a novel tool in the management of HF patients. The present review aims at analysing the most recent studies supporting pathogenesis, diagnosis, and management in patients with obesity and HF.
Optimal combination of right ventricular functional parameters using echocardiography in pulmonary arterial hypertension
Authors: Li Qimou , Zhang Yu , Cui Xiaopei , Lu Weida , Ji Qiushang , Zhang Mei 
Published: March 2024

AbstractAimsNovel echocardiographic parameters of right ventricular (RV) function, including speckle‐tracking‐derived, three‐dimensional, and RV–pulmonary artery coupling parameters, have emerged for the evaluation of pulmonary arterial hypertension (PAH). The relative role of these parameters in the risk stratification of PAH patients is unclear. We compared the performance of multiple RV parameters and sought to establish an optimal model for identifying the risk profile of patients with PAH.Methods and resultsComprehensive risk assessments were performed for 70 patients with PAH. The risk profile of every patient was determined based on the guideline recommendations. Conventional parameters, including fractional area change (FAC) and tricuspid annular plane systolic excursion (TAPSE), novel speckle‐tracking‐derived RV longitudinal strain (RVLS), and three‐dimensional RV ejection fraction (3D‐RVEF), were used to evaluate RV function. Pressure–strain loops were measured for the assessment of RV myocardial work, including RV global wasted work (RVGWW). RV–pulmonary artery coupling was assessed by indexing RV parameters to the estimated pulmonary artery systolic pressure (PASP). The median age was 34 (30–43) years, and 62 (88.6%) patients were female. Forty‐five patients were classified into the low‐risk group, while 25 patients were classified into the intermediate–high‐risk group. Most RV parameters could be used to determine the risk profile and exhibited significantly improved diagnostic performance after indexing to PASP (including FAC/PASP, TAPSE/PASP, and 3D‐RVEF/PASP). RVLS/PASP showed the best performance, with an area under the curve of 0.895. In multivariate analysis (Model 1), only RVGWW (>90.5 mmHg%), RVLS (> −16.7%), and TAPSE (<17.5 mm) remained significant (all P < 0.05). Model 1 outperformed every single RV parameter, with a significantly larger area under the curve (all P < 0.05). With PASP indexing in Model 2, RVLS/PASP > −0.275 [odds ratio (OR) 20.63, 95% confidence interval (CI) 4.62–92.11, P < 0.001] and RVGWW > 90.5 mmHg% (OR 6.17, 95% CI 1.37–27.76, P = 0.018) independently identified a higher risk profile. The addition of RVGWW to two models determined incremental value in identification (continuous net reclassification improvement 1.058, 95% CI 0.639–1.477, P < 0.001).ConclusionsThe combination models for RV function outperformed any single parameter in identifying the risk profile of patients with PAH. Comprehensive assessment of RV–pulmonary artery coupling using multiparametric methods is clinically meaningful in patients with PAH.
Synthesis of β‐Aryl‐α,β‐Dehydroaminophosphonates by Pd‐Catalyzed Fujiwara–Moritani C−C Coupling
Authors: Sáez Javier , Dalmau David , Sayago Francisco J. , Urriolabeitia Esteban P. 
Published: March 2024

AbstractThe treatment of diethyl α,β‐dehydroaminophosphonate 1 with various arenes (ArH=toluene 2 a, benzene 2 b, anisole 2 c, bromobenzene 2 d, chlorobenzene 2 e, benzyl alcohol 2 f, p‐xylene 2 g) in acetic acid (AcOH) at 120 °C for 8 h in the presence of Pd(OAc)2 (10 % mol, OAc=acetate) and AgOAc (3.4 equivalents) results in the formation of the corresponding β‐aryl derivatives E‐Ar(H)C=C(NHAc)P(O)(OEt)2 3 a–3 g. The reaction proceeds through double C−H activation (arene and alkene) and subsequent C−C oxidative coupling (Fujiwara–Moritani reaction), processes catalyzed by Pd and assisted by Ag. The obtained products 3 a–3 g are isosteric analogs of phenylalanine and are obtained with high selectivity. Thus, geometrical E‐isomers have been obtained in all studied cases, however mixtures of ortho‐/meta‐/para‐isomers are observed when the activated position in the starting arene 2 is considered.
Thermal Performance Factor of Impinging Jet‐Angled Corrugated Solar Air Heaters
Authors: Raheem Aneeq , Siddique Waseem , Waheed Khalid , Aziz Imran , Javed Irfan , Qureshi Kamran , Zaki Muhammad , Raheem Muhammad Tabish , Yaseen Muhammad Muneeb 
Published: March 2024

Solar energy is a clean and sustainable source of power generation. There are various industrial and domestic applications of Solar Air Heaters (SAHs), but their low thermal efficiency poses a challenge. To improve thermal efficiency, a novel‐angled corrugated jet‐impinging channel has been proposed for the absorbing plate of SAHs. A numerical study has been performed for four different arrangements of jets, i.e., single circular, single square, 2 × 2 square, and 3 × 3 square jet array with four channels, i.e., 30°, 45°, 60°, and 90° corrugated over the Reynolds number range of 1600–2700 for the jet to target plate range of 4.9–15. It is observed that multiple jets impinging increases the heat transfer significantly. The optimization has been performed by instigating the parametric study. Flow and thermal profiles are studied. The 45° corrugated target plate with 3 × 3 multiple jet impingement, 4.9 jet‐to‐target plate distance, and 2700 Reynolds number is chosen to have the best thermal efficiency. A Thermal Performance Factor of around 8 was achieved as compared to the base case.
Evaluation of Chronic Effects of Potassium Chloride and Nickel on Survival, Growth, and Reproduction of a Unionid Mussel (Lampsilis siliquoidea)
Authors: Wang Ning , Kunz James L. , Cleveland Danielle , Dorman Rebecca A. , Steevens Jeffery A. , Raimondo Sandy , Augspurger Tom , Chris Barnhart M. 
Published: March 2024

AbstractThe ASTM International standard test method for freshwater mussels (E2455‐13) recommends 4‐week toxicity testing with juveniles to evaluate chronic effects on survival and growth. However, concerns remain that the method may not adequately address the sensitivity of mussels to longer term exposures (>4 weeks), particularly in relation to potential reproductive impairments. No standard method directly evaluates toxicant effects on mussel reproduction. The objectives of the present study were to (1) evaluate toxicity endpoints related to reproduction in fatmucket (Lampsilis siliquoidea) using two common reference toxicants, potassium chloride (KCl) and nickel (Ni); (2) evaluate the survival and growth of juvenile fatmucket in standard 4‐week and longer term (12‐week) KCl and Ni tests following a method refined from the standard method; and (3) compare the sensitivity of the reproductive endpoints with the endpoints obtained from the juvenile mussel tests. Reproductive toxicity tests were conducted by first exposing female fatmucket brooding mature larvae (glochidia) to five test concentrations of KCl and Ni for 6 weeks. Subsamples of the glochidia were then removed from the adults to determine three reproductive endpoints: (1) the viability of brooded glochidia; (2) the viability of free glochidia in a 24‐h exposure to the same toxicant concentrations as their mother; and (3) the success of glochidia parasitism on host fish. Mean viability of brooded glochidia was significantly reduced in the high KCl concentration (26 mg K/L) relative to the control, with a 20% effect concentration (EC20) of 14 mg K/L, but there were no significant differences between the control and any Ni treatment (EC20 > 95 µg Ni/L). The EC20s for viability of free glochidia after the additional 24‐h exposure and parasitism success were similar to the EC20s of brooded glochidia. The EC20s based on the most sensitive biomass endpoint in the 4‐week juvenile tests were 15 mg K/L and 91 µg Ni/L, similar to or greater than the EC20s from the reproductive KCl and Ni tests, respectively. When exposure duration in the juvenile tests was extended from 4 to 12 weeks, the EC20s decreased by more than 50% in the KCl test but by only 8% in the Ni test. Overall, these results indicate that a standard 4‐week test with juvenile mussels can prove effective for estimating effects in chronic exposures with different life stages although a longer term 12‐week exposure with juvenile mussels may reveal higher sensitivity of mussels to some toxicants, such as KCl. Environ Toxicol Chem 2024;43:1097–1111. © 2024 SETAC. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.