bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abnormal cerebral cortex structure in children with ADHD
Authors: Wolosin Sasha M. , Richardson Marin E. , Hennessey Joseph G. , Denckla Martha B. , Mostofsky Stewart H. 
Published: November 2007

AbstractObjective:Examination of cerebral cortical structure in children with Attention‐Deficit/Hyperactivity Disorder (ADHD) has thus far been principally limited to volume measures. In the current study, an automated surface‐based analysis technique was used to examine the ADHD‐associated differences in additional morphologic features of cerebral cortical gray matter structure, including surface area, thickness, and cortical folding.Methods:MPRAGE images were acquired from 21 children with ADHD (9 girls) and 35 typically developing controls (15 girls), aged 8–12 years. Statistical difference maps were used to compare mean cortical thickness between groups along the cortical surface. Cortical volume, surface area, mean thickness, and cortical folding were measured within regions of interest, including the right/left hemispheres, frontal, temporal, parietal, and occipital lobes within each hemisphere, and sub‐lobar regions.Results:Children with ADHD showed a decrease in total cerebral volume and total cortical volume of over 7 and 8%, respectively; volume reduction was observed throughout the cortex, with significant reduction in all four lobes bilaterally. The ADHD group also showed a decrease in surface area of over 7% bilaterally, and a significant decrease in cortical folding bilaterally. No significant differences in cortical thickness were detected.Conclusions:Results from the present study reveal that ADHD is associated with decreased cortical volume, surface area, and folding throughout the cerebral cortex. The findings suggest that decreased cortical folding is a key morphologic feature associated with ADHD. This would be consistent with onset early in neural development and could help to identify neurodevelopmental mechanisms that contribute to ADHD. Hum Brain Mapp 2009. © 2007 Wiley‐Liss, Inc.
Temporal variations of physical and hydrochemical properties of springs in the Mid‐Levels area, Hong Kong: results of a 1‐year comprehensive monitoring programme
Authors: Leung Chi‐Man , Jiao Jiu Jimmy 
Published: November 2007

AbstractSprings and seeps occur in the spaces around Po Hing Fong Street in the Mid‐Levels area, Hong Kong. Most of the springs occur through the drainage weepholes on retaining walls at the street. This paper first examines the geology and history of the springs. The paper then reports the findings from a 1‐year comprehensive spring monitoring programme. The temporal variations of flow rate, physiochemical parameters and hydrochemistry of the springs are discussed. The average temperatures of the springs were close to the mean air temperature, although there was a systematic lag time of 40 to 50 days between the peak air temperature and highest water temperatures. Spring waters from two rows of weepholes in the retaining wall showed significantly different physical and hydrochemical responses to the changes in rainfall and temperature, though their vertical distance is only about 1 m. The results suggest that water from the upper row of weepholes may represent a recharge source that is shallow or close to the spring outlets, whereas that from the lower row of weepholes may represent a recharge source that is much deeper or further up the hill. Although the spring flows increased rapidly after rainstorms, analysis of the total dissolved solids showed a delayed response to rainstorm events. The concentration of individual ions in the spring water varied in a unique way in response to rainstorm events. It is clear that the presence of underground man‐made drainage systems and the leakage from water mains in the study area may add complexity to the solute responses and transport mechanisms. Further studies are required to constrain the impacts of these man‐made structures on the hydrogeology of the springs. Copyright © 2007 John Wiley & Sons, Ltd.
Hyaluronan oligosaccharides sensitize lymphoma resistant cell lines to vincristine by modulating P‐glycoprotein activity and PI3K/Akt pathway
Authors: Cordo Russo Rosalía I. , García Mariana G. , Alaniz Laura , Blanco Guillermo , Alvarez Elida , Hajos Silvia E. 
Published: November 2007

AbstractMultidrug resistance (MDR) is one of the main reasons for failure of cancer therapy. It may be mediated by overexpression of ATP‐dependent efflux pumps or by alterations in survival or apoptotic pathways. Fragments generated by enzymatic degradation of hyaluronan (oHA) were able to modulate growth and cell survival and sensitize MDR breast cancer cells to cytotoxic drugs. In this work the relationship between oHA and MDR in lymphoid malignancies was analyzed using murine lymphoma cell lines resistant to doxorubicin (LBR‐D160) or vincristine (LBR‐V160) and a sensitive line (LBR‐). After oHA treatment, higher apoptosis levels were observed in the resistant cell lines than in the sensitive one. Besides, oHA sensitized LBR‐D160 and LBR‐V160 to vincristine showing increased apoptosis induction when used in combination with vincristine. Native hyaluronan failed to increase apoptosis levels. As different survival factors could be modulated by hyaluronan, we investigated the PI3K/Akt pathway through PIP3 production and phosphorylated Akt (p‐Akt) and survivin expression was also evaluated. Our results showed that oHA decreased p‐Akt in the 3 cell lines while anti‐CD44 treatment abolished this effect. Besides, survivin was downregulated only in LBR‐V160 by oHA. When Pgp function was evaluated, we observed that oHA were able to inhibit Pgp efflux in murine and human resistant cell lines in a CD44‐dependent way. In summary, we report for the first time that oHA per se modulate MDR in lymphoma cells by decreasing p‐Akt as well as Pgp activity, thus suggesting that oHA could be useful in combination with classical chemotherapy in MDR hematological malignancies. © 2007 Wiley‐Liss, Inc.
Closing the survival gap: Implementation of medulloblastoma protocols in a low‐income country through a twinning program
Authors: Qaddoumi Ibrahim , Musharbash Awni , Elayyan Maher , Mansour Asem , Al‐Hussaini Maysa , Drake James , Swaidan Maisa , Bartels Ute , Bouffet Eric 
Published: November 2007

AbstractSuccessful twinning initiatives have been reported in childhood leukemia. Pediatric neuro‐oncology requires a complex multidisciplinary approach and the feasibility of similar twinning programs is unknown. Twinning between King Hussein Cancer Center in Amman and the Hospital for Sick Children in Toronto started with e‐mail communications, and subsequently included monthly videoconferences and exchanges between institutions. The outcome of 35 newly diagnosed medulloblastoma patients (22 high‐risk and 13 average‐risk) treated during this period is reported. The 3‐year overall survival for average risk and high‐risk patients was 100 and 81%, respectively. This experience suggests that twinning may facilitate the implementation of multidisciplinary neuro‐oncology programs in low‐income countries. Videoconferencing allows interactive exchanges with a significant learning impact. © 2007 Wiley‐Liss, Inc.
Foci formation of P53‐binding protein 1 in thyroid tumors: Activation of genomic instability during thyroid carcinogenesis
Authors: Nakashima Masahiro , Suzuki Keiji , Meirmanov Serik , Naruke Yuki , Matsuu‐Matsuyama Mutsumi , Shichijo Kazuko , Saenko Vladimir , Kondo Hisayoshi , Hayashi Tomayoshi , Ito Masahiro , Yamashita Shunichi , Sekine Ichiro 
Published: November 2007

AbstractDefective DNA damage response (DDR) can result in genomic instability (GIN) and lead to the transformation into cancer. P53‐binding protein 1 (53BP1) belongs to a family of evolutionarily conserved DDR proteins. Because 53BP1 molecules localize at the sites of DNA double strand breaks (DSBs) and rapidly form nuclear foci, the presence of 53BP1 foci can be considered as a cytologic marker for endogenous DSBs reflecting GIN. Although it has been proposed that GIN has a crucial role in the progression of thyroid neoplasms, the significance of GIN during thyroid tumorigenesis remains unclear, particularly in patients. We analyzed, therefore, the level of GIN, as detected with immunofluorescence of 53BP1, in 40 cases of resected thyroid tissues. This study demonstrated a number of nuclear 53BP1 foci in thyroid cancers, suggesting a constitutive activation of DDR in thyroid cancer cells. Because follicular adenoma also showed a few 53BP1 nuclear foci, GIN might be induced at a precancerous stage of thyroid tumorigenesis. Furthermore, high‐grade thyroid cancers prominently exhibited an intense and heterogeneous nuclear staining of 53BP1 immunoreactivity, which was also observed in radiation‐associated cancers and in mouse colonic crypts as a delayed response to a high dose ionizing radiation, suggesting increased GIN with progression of cancer. Thus, the present study demonstrated a difference in the staining pattern of 53BP1 during thyroid carcinogenesis. We propose that immunofluorescence analysis of 53BP1 expression can be a useful tool to estimate the level of GIN and, simultaneously, the malignant potency of human thyroid tumors. © 2007 Wiley‐Liss, Inc.
Uptake of two 10B‐compounds in liver metastases of colorectal adenocarcinoma for extracorporeal irradiation with boron neutron capture therapy (EORTC Trial 11001)
Authors: Wittig Andrea , Malago Massimo , Collette Laurence , Huiskamp René , Bührmann Sandra , Nievaart Victor , Kaiser Gernot M. , Jöckel Karl‐Heinz , Schmid Kurt Werner , Ortmann Uta , Sauerwein Wolfgang A. 
Published: November 2007

AbstractDisseminated metastases of colorectal cancer in liver are incurable. The trial EORTC 11001 investigates whether autotransplantation after extracorporeal irradiation of the liver by boron neutron capture therapy (BNCT) might become a curative treatment option because of selective uptake of the compounds sodium mercaptoundecahydro‐closo‐dodecaborate (BSH) or L‐para‐boronophenylalanine (BPA). BSH (50 mg/kg bw) or BPA (100 mg/kg bw) were infused into patients who subsequently underwent resection of hepatic metastases. Blood and tissue samples were analyzed forthe 10B‐concentration with prompt gamma ray spectroscopy (PGRS). Three patients received BSH and 3 received BPA. Adverse effects from the boron carriers did not occur. For BSH, the highest 10B‐concentration was observed in liver (31.5 ± 2.7 μg/g) followed by blood (24.8 ± 4.7 μg/g) and tumor (23.2 ± 2.1 μg/g) with a mean 10B‐concentration ratio metastasis/liver of 0.72 ± 0.07. For BPA, the highest 10B‐concentration was measured in metastases (12.1 ± 2.2 μg/g) followed by liver (8.5 ± 0.5 μg/g) and blood (5.8 ± 0.8 μg/g). As BPA is transported actively into cells, viable, metabolically active cells accumulate exclusively this compound. Consequently, a model is proposed to adjust the values measured by PGRS for the proportion of viable cells to express the relevant 10B‐concentration in the tumor cells, revealing a 10B‐concentration ratio metastasis/liver of 6.8 ± 1.7. In conclusion, BSH is not suitable as 10B‐carrier in liver metastases as the 10B‐concentration in liver was higher compared to metastasis. BPA accumulates in hepatic metastases to an extent that allows for extracorporeal irradiation of the liver with BNCT. © 2007 Wiley‐Liss, Inc.
Decomposing complete equipartite graphs into cycles of length 2p
Authors: Smith Benjamin R. 
Published: November 2007

AbstractIt is an open problem to determine whether a complete equipartite graph $K_m*{\overline{K}}_n$ (having m parts of size n) admits a decomposition into cycles of arbitrary fixed length $k$ whenever m, n, and k satisfy the obvious necessary conditions for the existence of such a decomposition. Recently, Manikandan and Paulraja [6] have shown the necessary conditions are indeed sufficient for a decomposition into cycles of length p where $p>5$ is a prime. The case $p=3$ was settled by Hanani [4] and the case $p=5$ was settled by Billington et al. [2]. Here, we extend this result and show that the necessary conditions for the decomposition of $K_m*{\overline{K}}_n$ into cycles of length $2p$ (where $p\ge 3$ is a prime) are also sufficient. © 2007 Wiley Periodicals, Inc. J Combin Designs 16: 244–252, 2008
Time‐domain sensitivity analysis of planar structures using first‐order one‐way wave‐equation boundaries
Authors: Basl Peter A. W. , Bakr Mohamed H. , Nikolova Natalia K. 
Published: November 2007

AbstractAn efficient adjoint variable method technique is developed for time‐domain sensitivity analysis of planar structures with transmission‐line modeling complemented by a first‐order one‐way wave‐equation absorbing boundaries. A backward‐running adjoint simulation is derived and solved. The validity of the technique is illustrated through three microstrip circuits. The examples demonstrate the efficiency and accuracy of the technique in comparison with the classical finite‐difference approaches to the estimation of the response sensitivities. Copyright © 2007 John Wiley & Sons, Ltd.
A comparison of spatial interpolation methods to estimate continuous wind speed surfaces using irregularly distributed data from England and Wales
Authors: Luo W. , Taylor M. C. , Parker S. R. 
Published: November 2007

AbstractSeven methods of spatial interpolation were compared to determine their suitability for estimating daily mean wind speed surfaces, from data recorded at nearly 190 locations across England and Wales. The eventual purpose of producing such surfaces is to help estimate the daily spread of pathogens causing crop diseases as they move across regions. The interpolation techniques included four deterministic and three geostatistical methods. Quantitative assessment of the continuous surfaces showed that there was a large difference between the accuracy of the seven interpolation methods and that the geostatistical methods were superior to deterministic methods. Further analyses, testing the reliability of the results, showed that measurement accuracy, density, distribution and spatial variability had a substantial influence on the accuracy of the interpolation methods. Independent wind speed data from ten other dates were used to confirm the robustness of the best interpolation methods. © Crown copyright 2007. Reproduced with the permission of Her Majesty's Stationery Office. Published by John Wiley & Sons, Ltd.
Stadium attendance and television audience demand in English league football
Authors: Buraimo Babatunde 
Published: November 2007

AbstractDemand studies of professional team sports have traditionally focused on stadium attendance; however, advances in broadcasting mean that teams generate revenue from stadium goers and broadcasters alike. Previous studies of demand have focused on stadium attendance and television audiences, but none have assessed the demand for match‐day attendances and demand by television audiences jointly. This study models match‐day attendances and television audiences using data from tier‐two of English league football. It shows that while televised matches depress stadium attendances, ceteris paribus, there is an important feedback in that larger stadium attendances have positive impacts on the size of television audiences. Copyright © 2007 John Wiley & Sons, Ltd.
A preliminary analysis of the use of resources in intelligent information access research
Authors: Chen Jiangping , Li Fei , Xuan Cong 
Published: November 2007

AbstractThis paper reports our exploratory analysis of the use of resources in three Intelligent Information Access (IIA) research areas: Automatic Classification, Question Answering, and Cross‐Language Information Retrieval. Forty‐three recently peer‐reviewed papers from three annual conferences (SIGIR, ACL, and HLT) were selected and analyzed. The purpose of this analysis is twofold: 1) to explore methodological issues for large‐scale content analysis of resources used in IIA research, and 2) to achieve a basic understanding of various ways that resources can be used in the three IIA subfields. The work reported in this paper is part of an effort to systematically explore the information needs for resources in Intelligent Information Access research.
Factors influencing knowledge sharing in the financial management community of practice of the USAF portal
Authors: Orhun Emrah , Hopple James 
Published: November 2007

AbstractThe aim of this study is to develop an understanding of the factors influencing participants' knowledge sharing in an electronic community of practice. The study builds on a theoretical framework derived from the theories of social capital and social exchange. A model of knowledge sharing in an electronic community of practice has been developed based on this framework. The model that considers the factors influencing the participants' intention to share their knowledge and their knowledge contribution has been empirically tested using a survey in the Financial Management Community of Practice in the USAF Portal. The results show that significant predictors of intention to share knowledge were self‐rated expertise, commitment and loss of knowledge power. Tenure in the field and reciprocity were the two significant predictors of knowledge contribution. The findings indicate that motivational factors and organizational rewards did not affect intention to share and knowledge contribution. The results also show that loss of knowledge power negatively affected intention to share suggesting a tendency to hoard knowledge.
Results on function and safety of the Safyre‐t, a hybrid transobturator vaginal sling for the treatment of stress urinary incontinence
Authors: Kuschel Stefanie , Schuessler Bernhard 
Published: November 2007

AbstractAimsTo examine the efficacy and safety of the Safyre‐t vaginal sling.Methods108 women with a Safyre‐t were invited for a gynecological follow up examination.Results79/108 patients showed up for an examination at 20 ± 4 months 59.5% stated that they were subjectively dry. Vaginal sling erosion was found in 8.8% of the patients and a pre‐erosive state in another 13.9%. The lateral silicone column could be palpated medial to the pubic bone in 47% of the patients indicating dislocation. 6/53 sexually active women complained of dyspareunia and one women stated that her partner had felt discomfort during sexual intercourse since her vaginal sling surgery.ConclusionsThis study shows that despite high patient satisfaction and acceptable subjective continence rates, the Safyre‐t was associated with a comparatively high rate of vaginal sling erosions and dislocations. Neurourol. Urodynam. 27:403–406, 2008. © 2007 Wiley‐Liss, Inc.
Does the type of bladder augmentation influence the resolution of pre‐existing vesicoureteral reflux? Urodynamic studies
Authors: Juhasz Z. , Somogyi R. , Vajda P. , Oberritter Z. , Fathi K. , Pinter A.B. 
Published: November 2007

AbstractAimsThe type of bladder augmentation on pre‐existing vesicoureteral reflux (VUR) was assessed. The effects of urodynamic changes on the resolution of VUR following augmentation cystoplasty performed with various gastrointestinal segments were examined. It was queried whether elimination of high‐pressure bladder is sufficient to resolve pre‐existing reflux.MethodsA retrospective record review of patients who underwent bladder augmentation between 1987 and 2004. Patients were divided into two groups. Group I included patients who had a simultaneous augmentation and ureteral reimplantation. Group II included patients with reflux in whom only a bladder augmentation was performed. Pre‐and post‐augmentation urodynamic results were compared in both groups. The outcome of VUR and the role of various gastrointestinal (GI) segments on the resolution of VUR were studied.ResultsSixty‐three patients underwent bladder augmentation during the study period. Twenty‐six of them had VUR before augmentation. There were 10 patients in Group I and 16 patients in Group II. In Group I, VUR ceased in all patients, while in group II, VUR resolved in 14 patients and persisted in two patients. Small and large bowel segments used for augmentation had no effect on the resolution of VUR but the results of gastrocystoplasties were less favorable. Urodynamically there was no significant difference between the various augmentation cystoplasties.ConclusionsBladder augmentation alone without simultaneous antireflux repair is usually sufficient for the resolution of pre‐existing reflux. The various GI segments used for augmentation have no effect on urodynamic results and the resolution of VUR. Neurourol. Urodynam. 27:412–416, 2008. © 2007 Wiley‐Liss, Inc.
3D symplectic expansion for piezoelectric media
Authors: Xu Xin‐Sheng , Leung Andrew Y. T. , Gu Qian , Yang Hao , Zheng Jian‐Jun 
Published: November 2007

AbstractThe symplectic series expansion method is extended to three‐dimensional problem for transversely isotropic piezoelectric media. The governing equations are first derived in Hamiltonian form, and symplectic eigensolutions are directly obtained through analytical method. All solutions of the problem are reduced to finding eigenvalues and eigensolutions. The classical St Venant solutions are described by zero‐eigensolutions, and the localized solutions are depicted by non‐zero‐eigensolutions. Symplectic relationships of the ortho‐normalization are used, end conditions are rewritten by eigensolutions, and a numerical scheme is formed analytically. Some numerical examples are given. Copyright © 2007 John Wiley & Sons, Ltd.
Reflective and conductive surface‐silvered polyimide films prepared by surface graft copolymerization and electroless plating
Authors: Wu Dezhen , Zhang Tao , Wang Wen‐Cai , Zhang Liqun , Jin Riguang 
Published: November 2007

AbstractArgon plasma‐pretreated polyimide (PI) films were subjected to UV‐induced surface graft copolymerization with 4‐vinylpyridine(4VP) under atmospheric conditions. Electroless plating of silver was carried out effectively on the 4VP graft copolymerized PI (PI‐g‐P4VP) surface after PdCl2 activation and in the absence of SnCl2 sensitization (the Sn‐free process). The surface compositions of the modified PI films were studied by X‐ray photoelectron spectroscopy (XPS). XPS results showed that the PI‐g‐P4VP surface is ready for electroless deposition of silver via the Sn‐free process. The grafted 4VP layer with well‐preserved pyridine groups was used not only as the chemisorption sites for the palladium complexes (without the need for prior sensitization by SnCl2) during the electroless plating of silver, but also as an adhesion promotion layer for the electrolessly deposited silver. The silver metallized PI films show high reflectivity and conductivity with a surface resistance of 1.5 Ω and a reflectivity of 91.3%, respectively. Copyright © 2007 John Wiley & Sons, Ltd.