bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Outcomes of Biologic Therapies for Fistulizing Crohn's Disease: A Systematic Review
Authors: Okezie Chidera Emmanuel , Asinde Angioshuye , Goswami Roshan , Okpara Clara C. , Goshe Mulusew Tibebu , Bamikole Opeyemi Oluwatobi , Anyiman Tope Mwuese , Nzotta Chiedozie Steven , Uzochukwu Chiamaka Vivien , Razaq Sajid , Nayab Khudija , Chukwuneta Chidera Precious , Chioma Ogochukwu Ekpeleamaka , Oraekwute Ifeyinwa Monica , Rahman Farzana 
Published: April 2024

Background: Fistulizing Crohn's Disease (FCD) is a distinct and aggressive subset of Crohn's Disease, contributing to substantial morbidity, hospitalizations, and reduced patient well-being. The intricate interplay of factors influencing FCD outcomes warrants an in-depth exploration to refine patient care and therapeutic strategies. The aim of this paper is to conduct a comprehensive systematic review to critically evaluate the effectiveness, safety, and cost-effectiveness of biologic therapies and other interventions for FCD
Methods: In line with the PRISMA Statement 2020 guidelines, we conducted a systematic review. We extensively searched databases including PubMed, Embase, and Cochrane Library, with the last search update on November 5, 2023. Studies evaluating FCD patients were examined, emphasizing the disease's clinical burden and influential parameters. Observational studies that underlined treatments and various FCD management strategies correlating with clinical outcomes were primarily considered for inclusion.
Results: Beginning with an initial review of 438 studies, ten met the inclusion criteria and were incorporated into this systematic review. A total of 1122 patients were included. Spanning the years 2014–2022, the incorporated studies delve into diverse FCD treatment modalities. These range from the use of anti-TNF agents, surgical procedures, stem cell therapies, drug amalgamations, to intensifying dosing regimens. The synthesized findings from these studies carve out a progressively evolving treatment milieu for Crohn's disease, emphasizing the indispensability of individualized and empirically supported therapeutic avenues.
Conclusion: FCD presents a formidable challenge in the realm of inflammatory bowel diseases, impacting patient outcomes. This review accentuates the pivotal nature of comprehensive care, early intervention, and addressing intricate disease mechanisms. The collated evidence highlights an imperative for innovative care modalities, targeted therapeutic endeavors, and tailored interventions to manage FCD more effectively and improve patient prognosis.
A Comprehensive Analysis of Risk Factors of Diabetic Nephropathy and Exploring the Treatment Pattern
Authors: Pal Aritra , Bhanja Asish , Williams Joy , Geddam Vineesha , Bendurthi Chandana , Sah Bipin , Marwein Bashongdor , Ghosh Arka , Rajkonwar Anurag , Sana Praveen , Kumari Ratna 
Published: April 2024

Aims: The study aims to comprehensively analyze diabetic nephropathy's risk factors and treatment patterns, exploring diverse factors for enhanced prevention and personalized management.
Study Design: Prospective study design.
Place and Duration of Study: The study was conducted for 5 months at Trust Multispeciality Hospital, Kakinada.
Methodology: This retroactive chart analysis of non-critical outpatients folders of Trust Hospital that refers to the mentioned period (11/2022 -04/2023) will use Excel software.
Results: A variety of risk factors promote the development and progression of diabetic nephropathy, including elevated glucose levels, high blood pressure, obesity, the long duration of diabetes, and dyslipidemia. These risk factors are modifiable by hyperglycemic agents, anti-hypertensives, and lipid-lowering agents. Most of the people who are prone to diabetic nephropathy are between 40 and 70 years of age. Males are most affected (80%) compared to females (20%). Oral hypoglycemic agents (97%) and calcium channel blockers (50%) play a major role in reducing the progression of diabetic nephropathy by controlling blood pressure and glucose levels in the subject. Obesity is also a notable risk factor for end-stage renal disease patients.
ChemInform Abstract: Pd(OAc)2/p‐Benzoquinone‐Catalyzed Anaerobic Electrooxidative Homocoupling of Arylboronic Acids, Arylboronates and Aryltrifluoroborates in DMF and/or Water.
Authors: Amatore Christian , Cammoun Chama , Jutand Anny 
Published: January 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Preference of β‐Lactam Formation in Cu(I)‐Catalyzed Intramolecular Coupling of Amides with Vinyl Bromides.
Authors: Zhao Qiwu , Li Chaozhong 
Published: January 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: From Dioxime Oxalates to Dihydropyrroles and Phenanthridines via Iminyl Radicals.
Authors: Portela‐Cubillo Fernando , Scanlan Eoin M. , Scott Jackie S. , Walton John C. 
Published: January 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Reaction of α‐Nitrocinnamic Acid Esters with Pyrrole.
Authors: Baichurina L. V. , Baichurin R. I. , Aboskalova N. I. , Berkova G. A. , Berestovitskaya V. M. 
Published: January 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A New Synthesis of Hemialdals and Their Stereoselective Tandem Reaction in the Construction of 1,3‐Dioxolane Derivatives.
Authors: Shao Qiyun , Li Chunbao 
Published: January 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: One‐Pot Parallel Solution‐Phase Synthesis of 1‐Substituted 4‐(2‐Aminoethyl)‐1H‐pyrazol‐5‐ols.
Authors: Kralj David , Novak Ana , Dahmann Georg , Groselj Uros , Meden Anton , Svete Jurij 
Published: January 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of 2‐Benzylimidazo[2,1‐b][1,3]benzothiazoles Through Palladium‐Catalyzed Heteroannulation of Acetylenic Compounds.
Authors: Bakherad Mohammad , Nasr‐Isfahani Hossein , Keivanloo Ali , Sang Golnaz 
Published: January 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Selective Aromatic Carbon—Oxygen Bond Cleavage of Trifluoromethoxyarenes: A Trifluoromethoxy Group as a Convertible Directing Group.
Authors: Iijima Akinori , Amii Hideki 
Published: January 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Nakijiquinones G—I, New Sesquiterpenoid Quinones from Marine Sponge.
Authors: Takahashi Yohei , Kubota Takaaki , Ito Junji , Mikami Yuzuru , Fromont Jane , Kobayashi Jun'ichi 
Published: January 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthetic Studies of 3‐(3‐Fluorooxindol‐3‐yl)‐L‐alanine.
Authors: Fujiwara Tomoya , Yin Bin , Jin Meixiang , Kirk Kenneth L. , Takeuchi Yoshio 
Published: January 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of 2′,3′‐Dideoxy‐6′,6′‐difluoro‐3′‐azanucleosides.
Authors: Yue Xuyi , Qiu Xiao‐Long , Qing Feng‐Ling 
Published: January 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Tetrahydrobostrycin (Ia) and 1‐Deoxytetrahydrobostrycin (Ib), Two New Hexahydroanthrone Derivatives, from a Marine‐Derived Fungus Aspergillus sp.
Authors: Xu Jinzhong , Nakazawa Takahiro , Ukai Kazuyo , Kobayashi Hisayoshi , Mangindaan Remy E. P. , Wewengkang Defny S. , Rotinsulu Henki , Namikoshi Michio 
Published: January 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Concise Stereoselective Synthesis of (‐)‐Podophyllotoxin (VI) by an Intermolecular Iron(III)‐Catalyzed Friedel—Crafts Alkylation.
Authors: Stadler Daniel , Bach Thorsten 
Published: January 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Total Synthesis and Determination of the Absolute Configuration of Guadinomines B (I) and C2 (II).
Authors: Hirose Tomoyasu , Sunazuka Toshiaki , Tsuchiya Satoshi , Tanaka Toshiaki , Kojima Yasuhiro , Mori Ryuma , Iwatsuki Masato , Omura Satoshi 
Published: January 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Fully Automated Molecular Mechanics Based Induced Fit Protein—Ligand Docking Method.
Authors: Koska Juergen , Spassov Velin Z. , Maynard Allister J. , Yan Lisa , Austin Nic , Flook Paul K. , Venkatachalam C. M. 
Published: January 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Electronic Structure Study of Thermal Intraconversions of Some Dicyclopenta‐Fused Polycyclic Aromatic Compounds.
Authors: Markovic Svetlana , Stankovic Sonja , Radenkovic Slavko , Gutman Ivan 
Published: January 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Chirality in Polyoxometalate Chemistry
Authors: Hasenknopf Bernold , Micoine Kevin , Lacote Emmanuel , Thorimbert Serge , Malacria Max , Thouvenot Rene 
Published: January 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Mono‐ and Bidentate Benzannulated N‐Heterocyclic Germylenes, Stannylenes and Plumbylenes
Authors: Zabula Alexander V. , Hahn F. Ekkehardt 
Published: January 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Dinuclear Chiral Vanadium Catalysts for Oxidative Coupling of 2‐Naphthols via a Dual Activation Mechanism
Authors: Takizawa Shinobu , Katayama Tomomi , Sasai Hiroaki 
Published: January 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Carbohydrate Microarrays as Powerful Tools in Studies of Carbohydrate‐Mediated Biological Processes
Authors: Park Sungjin , Lee Myung‐Ryul , Shin Injae 
Published: January 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Sovents from Nature
Authors: Horvath Istvan T. 
Published: January 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Chemistry and Applications of 4,5‐Diazafluorenes
Authors: Ono Katsuhiko , Saito Katsuhiro 
Published: January 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: π‐Acidic Alkene Ligand Effects in Pd‐Catalyzed Cross‐Coupling Processes. Exploiting the Interaction of Dibenzylidene Acetone (dba) and Related Ligands with Pd(0) and Pd(II).
Authors: Fairlamb Ian J. S. 
Published: January 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Wet and dry summers in Europe since 1750: evidence of increasing drought
Authors: Briffa K. R. , van der Schrier G. , Jones P. D. 
Published: January 2009

AbstractMoisture availability across Europe is calculated based on 22 stations that have long instrumental records for precipitation and temperature. The metric used is the self‐calibrating Palmer Drought Severity Index (scPDSI) which is based on soil moisture content. This quantity is calculated using a simplified water budget model, forced by historic records of precipitation and temperature data, where the latter are used in a simple parameterization for potential evaporation. The precipitation and temperature records are updated to include the 2003 summer and all records, except for one, span at least 200 years, with the record for Kew going back to 1697.The Kew record shows a significant clustering of dry summers in the most recent decade. When all the records are considered together, recent widespread drying is clearly apparent and highly significant in this long‐term context.By substituting the 1961–1990 climatological monthly mean temperatures for the actual monthly means in the parameterization for potential evaporation, an estimate is made of the direct effect of temperature on drought. This analysis shows that a major influence on the trend toward drier summer conditions is the observed increase in temperatures. This effect is particularly strong in central Europe.Based on the 22 scPDSI records, a gridded scPDSI dataset covering a large part of Europe has been constructed and compared to a recent high‐resolution scPDSI dataset spanning the twentieth century only. We again observe that a major cause for the large areal extent of summer drought in the last two decades is high temperatures. Temperatures in the 12 months preceding and including the summer of 2003 explain an increase in the areas experiencing slightly dry (or worse) conditions of 11.1%. Copyright © 2009 Royal Meteorological Society
Multi‐indices analysis of southern Scandinavian storminess 1780–2005 and links to interdecadal variations in the NW Europe–North Sea region
Authors: Bärring Lars , Fortuniak Krzysztof 
Published: January 2009

AbstractExtra‐tropical cyclone frequency and intensity are currently under intense scrutiny because of the destruction recent windstorms have brought to Europe, and because they are a major meridional heat transport mechanism that may respond to differential latitudinal warming trends. Several studies using reanalysis data covering the second half of the 20th century suggest increasing storm intensity in the northeastern Atlantic and European sector. Fewer analyses cover a longer time period but show different trends or point towards the dominance of interdecadal variability instead of any clear trends. Hence, it is relevant to analyse cyclone variability over as long a period as possible. In this study, we analyse interdecadal variability in cyclone activity over northwestern Europe back to AD 1780 by combining information from eight storminess indices applied in an Eulerian framework. These indices, including four new approaches towards gauging cyclone activity, use the series of thrice‐daily sea level pressure observations at Lund and Stockholm. We find pronounced interdecadal variability in cyclonic activity but no significant overall consistent long‐term trend. The major interdecadal‐scale variability common to all indices is in good agreement with geostrophic wind reconstructions for NE Atlantic and NW Europe, and with variations in the North Atlantic oscillation (NAO). Our results show that the reanalysis studies cover a time period chiefly coinciding with a marked, but not exceptional in our 225‐year perspective, positive variation in the regional cyclone activity that has more recently reversed. Because of the interdecadal variations, a near‐centennial time perspective is needed when analysing variations in extra‐tropical cyclone activity and the associated weather conditions over northwestern Europe. Copyright © 2009 Royal Meteorological Society
Liquid crystal alignment property of n‐alkylthiomethyl‐ or n‐alkylsulfonylmethyl‐substituted polystyrenes
Authors: Kang Hyo , Park Jin Seol , Kang Daeseung , Lee Jong‐Chan 
Published: January 2009

AbstractWe synthesized a series of n‐alkylthiomethyl‐substituted polystyrenes (#T‐PS, # = 4, 8, 12, and 16) and n‐alkylsulfonylmethyl‐substituted polystyrenes (#S‐PS, # = 4, 8, 12, and 16), where # is the number of carbon atoms in the n‐alkyl side group of the polymers, using polymer analogous reactions to investigate their liquid crystal (LC) alignment properties. In general, the LC cell fabricated using the polymer film having a longer n‐alkyl side group, a thioether linkage group, and a higher molar content of n‐alkyl side group showed homeotropic LC alignment behavior with a pretilt angle of about 90°. The homeotropic alignment behavior was well correlated with the surface energy of the polymer films; when the positive dielectric anisotropic LC (ZLI‐5900‐000 from Merck) and negative dielectric anisotropic LC (MLC‐7026‐000 from Merck) were used to fabricate the LC cells, homeotropic alignment was observed when the surface energy values of the polymer were smaller than about 25 and 32 mJ/m2, respectively. Copyright © 2009 John Wiley & Sons, Ltd.
Properties of the N‐terminal domains from Y receptors probed by NMR spectroscopy
Authors: Zou Chao , Kumaran Sowmini , Walser Reto , Zerbe Oliver 
Published: January 2009

AbstractBinding of neurohormones from the NPY family to their receptors, the so‐called Y receptors, that belong to the superfamily 1b of G‐protein coupled receptors might include transient binding to the N‐terminal domains of the receptors. Accordingly, we have studied structural features of the N‐terminal domains from the Y1, Y2, Y4, and Y5 receptor subtypes (N‐Y1, N‐Y2, N‐Y4, N‐Y5). We developed efficient strategies for their recombinant expression. N‐Y4 and N‐Y1 were expressed as insoluble fusions to enforce accumulation into inclusion bodies, whereas N‐Y2 and N‐Y5 were expressed as soluble fusion proteins. All N‐terminal domains are fully flexible in aqueous buffer. In the presence of phospholipid micelles some stretches within the polypeptides adopt helical conformations, but these are too unstable to be characterized in detail. Using chemical shift mapping techniques, interactions of NPY, peptide YY (PYY), and pancreatic polypeptide (PP), the three members of the neurohormone family that are the Y receptors' natural ligands, with N‐Y1, N‐Y2, and N‐Y5 revealed chemical shift changes in all cases, with the largest values being encountered for PP interacting with N‐Y1 or N‐Y5 both in the presence and in the absence of phospholipid micelles. The strength of the interactions, however, is generally weak, and the data also point to nonspecific contacts. Previously, in case of the interaction of N‐Y4 with PP, the contacts were shown to be electrostatic in nature. This work indicates that association of the peptides with the N‐terminal domains may generally be part of their binding trajectory. Copyright © 2008 European Peptide Society and John Wiley & Sons, Ltd.