bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adiponectin Reduces Glomerular Endothelial Glycocalyx Disruption and Restores Glomerular Barrier Function in a Mouse Model of Type 2 Diabetes
Authors: Fawaz Sarah , Martin Alonso Aldara , Qiu Yan , Ramnath Raina , Stowell-Connolly Holly , Gamez Monica , May Carl , Down Colin , Coward Richard J. , Butler Matthew J. , Welsh Gavin I. , Satchell Simon C. , Foster Rebecca R. 
Published: March 2024

Adiponectin has vascular anti-inflammatory and protective effects. Although adiponectin protects against the development of albuminuria, historically, the focus has been on podocyte protection within the glomerular filtration barrier (GFB). The first barrier to albumin in the GFB is the endothelial glycocalyx (eGlx), a surface gel-like barrier covering glomerular endothelial cells (GEnCs). In diabetes, eGlx dysfunction occurs before podocyte damage; hence, we hypothesized that adiponectin could protect from eGlx damage to prevent early vascular damage in diabetic kidney disease (DKD). Globular adiponectin (gAd) activated AMPK signaling in human GEnCs through AdipoR1. It significantly reduced eGlx shedding and the tumor necrosis factor-α (TNF-α)–mediated increase in syndecan-4 (SDC4) and MMP2 mRNA expression in GEnCs in vitro. It protected against increased TNF-α mRNA expression in glomeruli isolated from db/db mice and against expression of genes associated with glycocalyx shedding (namely, SDC4, MMP2, and MMP9). In addition, gAd protected against increased glomerular albumin permeability (Ps’alb) in glomeruli isolated from db/db mice when administered intraperitoneally and when applied directly to glomeruli (ex vivo). Ps’alb was inversely correlated with eGlx depth in vivo. In summary, adiponectin restored eGlx depth, which was correlated with improved glomerular barrier function, in diabetes.

Article Highlights
Análisis de la biodiversidad desde una perspectiva socioambiental en Las Vigas, Guerrero, México
Authors: Bedolla Solano Ramón , Bedolla Solano Juan José , Bedolla Solano Silvestre , Miranda Esteban Adriana 
Published: March 2024

La biodiversidad hace referencia a la vida en la tierra, incluye todos los seres vivos, plantas, animales, etc. Este estudio se centra en la biodiversidad de la comunidad de Las Vigas, Guerrero, abordando sus diversos aspectos desde una perspectiva socioambiental. El estado que guarda la biodiversidad puede ser analizado desde diversos campos de las ciencias y enfoques. La investigación surge ante la creciente preocupación de las actividades antrópicas, como la agricultura, construcción, contaminación, etc. que afectan negativamente la biodiversidad en la región. El objetivo principal fue realizar un análisis de la biodiversidad desde una perspectiva socioambiental en la comunidad en cuestión, ubicada en la Costa Chica del Estado de Guerrero. Se utilizó un enfoque mixto que incluyó la observación simple en zonas del lugar, la encuesta a 38 ciudadanos seleccionados por conveniencia y la entrevista a 42 informantes clave.
Los resultados en la observación revelaron la riqueza biodiversa en Las Vigas, aunque las actividades humanas amenazan su preservación. Con la encuesta, se evidenció deficiencias socioeconómicas entre los habitantes y un 63% mostró una conciencia general del impacto negativo en la biodiversidad. A pesar de este conocimiento, existe una brecha entre la conciencia y las prácticas de conservación, por ello, un 68% indicó una falta de cultura ambiental, así mismo, un 46% consideró la importancia de la biodiversidad. La entrevista profundizó en aspectos sociopolíticos y socioambientales, destacando la gravedad del problema. La conclusión subraya la amenaza que enfrenta la biodiversidad en Las Vigas y la necesidad urgente de medidas de protección.
Fish Pangek Processing Lake Singkarak In Solok Regency
Authors: Adawiyah Nadiatul , Elida Elida 
Published: March 2024

This research is motivated by pangek in general made from sea fish and no additional ingredients, this is different from the pangek in Nagari Paninggahan which is made from lake fish, namely bilih fish and sasaudan fish mixed with additional ingredients such as young nagka, young papaya, chayote, and sijangkang. This research was conducted with the aim of identifying the composition of ingredients, spices, tools used in making pangek in Nagari Paninggahan and explaining the processing process used in making pangek in Nagari Paninggahan.The type of research used is qualitative, the location of this research was carried out in Nagari Paninggahan, Junjung Sirih District, Solok Regency in October 2023. The data sources are Bundo Kandung and people who are experts in making pangek. Data collection techniques by conducting observations, interviews, and documentation. Data analysis in the field which includes data reduction, data presentation, conclusion drawing and verification. The results showed that pangek in Nagari Paninggahan is made from bilih fish and Sasau fish, as well as additional ingredients such as young jackfruit, young papaya, chayote and sijangkang. The spices used are red chili, shallots, garlic, ginger, galangal, lemongrass, turmeric leaves, lime leaves, bay leaves, ruku-ruku leaves, lemongrass and belimbing wuluh. The tools used are knives, plastic kom, grindstone or blender, cauldron or talenang, stove and samba plate. The process of making
Implementasi Sistem Operasi Perpustakaan dengan Aplikasi Slims di Perpustakaan Ismail Marzuki MAN 3 Pekanbaru
Authors: Rasdanelis Rasdanelis , Hidayani Hidayani , Ernawati Ernawati , Syahputra Eko 
Published: March 2024

Automated school libraries have become a necessity. Library automation systems have been designed and built by information technology experts, especially in the field of librarianship. SLiMS (Senayan Library Management System) is one of the well-known library automation applications and is widely used in various types of libraries. Ismail Marzuki MAN 3 Pekanbaru Library has developed a library management system into an automated library system using the SLiMS application. How is the implementation of the system, at the Ismail Marzuki MAN 3 Library Pekanbaru, the researchers conducted a descriptive study with a qualitative approach. Data was collected using interview, observation and documentation techniques. Based on the results and discussion of the research, it is known that the implementation of the SLiMS library automation application at the Ismail Marzuki MAN 3 Pekanbaru Library, goes through the following stages: Provision of hardware and software; Provision of managing resources; Selection of the appropriate system; System installation; and Operational systems for implementation of technical and user services, and are heavily influenced by budgetary support, management resources and availability of hardware and software.
Perpustakaan sekolah terotomasi sudah menjadi kebutuhan. Sistem otomasi perpustakaan telah banyak dirancang dan dibangun oleh para pakar teknologi informasi, terutama di bidang kepustakawanan. SLiMS (Senayan Library Management System) merupakan salah satu aplikasi otomasi perpustakaan terkenal dan banyak dimanfaatkan di perpustakaan dalam berbagai jenis. Perpustakaan Ismail Marzuki MAN 3 Pekanbaru telah melakukan pengembangan sistem pengelolaan perpustakaan menjadi sistem perpustakaan terotomasi menggunakan aplikasi SLiMS. Bagaimana implementasi sistem tersebut, di Perpustakaan Ismail Marzuki MAN 3 Pekanbaru, maka peneliti melakukan kajian deskriptif dengan pendekatan kualitatif. Data dikumpulkan menggunakan teknik wawancara, observasi dan dokumentasi. Berdasar hasil dan pembahasan penelitian, diketahui bahwa implementasi aplikasi otomasi perpustakaan SLiMS di Perpustakaan Ismail Marzuki MAN 3 Pekanbaru, melalui tahapan-tahapan: Penyediaan perangkat keras dan perangkat lunak; Penyediaan sumberdaya pengelola; Pemilihan sistem yang sesuai; Instalasi sistem; dan Operasional sistem untuk penerapan pada layanan teknis dan pemustaka, serta sangat dipengaruhi oleh dukungan anggaran, sumberdaya pengelola dan ketersediaan perangkat keras dan perangkat lunak.
Kata kunci: Perpustakaan Sekolah; Otomasi; SLiMS (Senayan Library Management System)
Rancang Bangun Mesin Extruder Plastik
Authors: Nurzaman Runo , Noubnome Viktor , Dirja Iman 
Published: March 2024

This research explores the potential of a plastic extruder machine as a solution to address plastic waste by utilizing high temperatures to melt and form plastic blocks. The machine aims to determine the optimal temperature for the production of plastic pellets. Despite initially producing plastic liquid, the machine is expected to effectively reduce plastic waste.
The machine specifications involve an electric motor, gearbox, melting furnace, intake, melting spiral, output, pulley, and V-belt. Analysis of electric motor planning determines the required power. Gearbox planning involves gearbox ratio and required torque. Planning for pulleys and V-belts is conducted to transmit power from the motor to the machine's drive system. Planning for shafts and bearings was also carried out.
The plastic extruder machine holds promise as a significant solution for plastic waste recycling. The manufacturing cost of the machine is found to be Rp17,349,350 and can be further reduced with a more optimal design. Recommendations for future research include enhancing detailed analysis and utilizing a richer set of references.
Yüzellilikler İçinde Manisa’da Görevli İsimler
Authors: Gülmez Nurettin , Aslan Kübra 
Published: March 2024

Kurtuluş Savaşı’nın bitmesi ile imzalanan Lozan Barış Antlaşması diğer barış antlaşmalarında olduğu gibi genel bir affı kapsamaktaydı. Ancak Millî Mücadele boyunca düşmanla iş birliği yapan, isyanlar çıkartan, Kuva-yı Milliye’ye karşı mücadele eden bazı kişilerin affedilmesi mümkün değildi. Bu yüzden Lozan Barış Antlaşması’na eklenen bir protokol ile yüz elli kişinin af dışı bırakılmasına karar verildi. Bundan sonraki süreç ilk olarak bu yüz elli kişinin belirlenme aşaması ile başlamış, bu kişilerin vatandaşlıktan çıkarılması ve 1938 yılında çıkan af ile yurda geri dönmelerine müsaade edilmesi şeklinde tamamlanmıştır.
Çalışmada konunun kapsadığı döneme ait tüm Meclis zabıtları incelenmiş ve ciddi bir arşiv taraması gerçekleştirilmiştir. Bu taramalar esnasında literatürde bulunmayan bazı bilgilere ulaşılmıştır. Ulaşılan belgeler kullanılarak bu kişiler hakkında çeşitli çalışmalarda verilen bilgi karmaşası ortadan kaldırılmaya çalışılmış, yeni bilgiler ve fotoğraflar eklenmiştir.
Bu yüz elli kişinin belirlenmesi sürecinde TBMM’de yapılan müzakerelerde ilk oluşturulan listede Manisa’dan hangi isimlerin olduğu, listeye Manisa’dan hangi isimlerin eklenmesinin istendiği ve listenin son halinde Manisa’dan hangi isimlerin yer aldığı incelenmiş. Sonrasında ise bu isimlerin neden yüz elli kişilik listede yer aldığı, yurt dışında oldukları süreçte neler yaptıkları, 1938 tarihli Af Kanunu ile yurda dönüp dönmedikleri ve dönenlerin ne yaptığı gibi sorulara cevap verilmeye çalışılmıştır.
Primer estándar de perfeccionamiento racial de la Gallina Mapuche (Gallus gallus domesticus) en Argentina: revisión, sistematización de datos y elaboración
Authors: Alonso Juan Manuel 
Published: March 2024

La avicultura ornamental cumple un rol valioso en la preservación del acervo genético y cultural de las aves de corral en todo el mundo. En la ruralidad argentina, la crianza de aves de raza pura es una actividad ampliamente difundida, y se encuentra representada por las distintas asociaciones de aficionados. El “Standard Argentino de Perfección Avícola”, publicado por la Asociación Argentina de Criadores de Aves, Conejos y Abejas, en el año 1928 fue, y aún sigue siendo, el patrón de referencia para el desarrollo de esta actividad. Por promoción de la Comisión Avícola del Sur del Salado, y en colaboración con otras asociaciones y organizaciones del país, se resolvió revisar, reescribir y reeditar dicho estándar, incorporando nuevas razas, como es el caso de la única gallina sudamericana, prehispánica, conocida en la actualidad: la Gallina Mapuche (Gallus gallus domesticus). En el presente trabajo se hace una revisión, sistematización de tareas, recopilación de datos de investigación, análisis y elaboración del inédito “Primer Estándar de Perfeccionamiento Racial de la Gallina Mapuche”, en Argentina.
Two lateral flow assays for detection of anti-coccidioidal antibodies show similar performance to immunodiffusion in dogs with coccidioidomycosis
Authors: Grill Francisca J. , Jaffey Jared A. , Grys Thomas E. , Rayhel Laura H. , Lake Douglas F. 
Published: March 2024

Abstract

OBJECTIVE
To compare 2 point-of-care lateral flow assays (LFAs) with immunodiffusion (ID) IgG results for anti-coccidioidal antibody detection in dogs with coccidioidomycosis. A further aim was to compare the quantifiable output of 1 of the LFAs to ID antibody titers.

SAMPLE
Serum banked from 73 client-owned dogs diagnosed with pulmonary or disseminated coccidioidomycosis.

METHODS
ID was used to determine antibody presence and titer against a coccidioidal antigen preparation. All sera were subsequently tested on an LFA based on recombinant chitinase 1 (CTS1) and the commercially available sōna LFA. LFA results were analyzed and compared to ID IgG results and clinical diagnosis.

RESULTS
All assays showed similar sensitivities in detecting anti-coccidioidal antibodies (83.6% to 89.0%). When compared with ID IgG, the CTS1 LFA had a positive percent agreement of 100%, while the sōna LFA had a positive percent agreement of 91.4%. Since the CTS1 LFA is semiquantitative, we were able to compare test line densities with ID titers and found a strong correlation between the 2 assays (Spearman ρ = 0.82).

CLINICAL RELEVANCE
This is the first side-by-side evaluation of a commercially available LFA (sōna) and a newer more rapid anti-CTS1 antibody LFA using serum from dogs with coccidioidomycosis. Both LFAs tested have similar sensitivity to ID IgG results. The CTS1 LFA can be read after 10 minutes and is semiquantitative, while the sōna LFA is read after 30 minutes, and the results are subject to interpretation. Accurate and fast detection of anti-coccidioidal antibodies allows clinicians to initiate appropriate treatment without diagnostic delay.
Myxomatous mitral valve disease and associated pulmonary hypertension might increase serum angiopoietin-2 in dogs
Authors: Yu Hogeun , Lee Dohee , Chae Yeon , Choi Minseok , Lee Yelim , Yun Taesik , Kang Byeong-Teck , Yang Mhan-Pyo , Kim Hakhyun 
Published: March 2024

Abstract

OBJECTIVE
To evaluate the relationships between the severity of myxomatous mitral valve disease (MMVD) and pulmonary hypertension (PH) and serum angiopoietin (Ang)-1 and Ang-2 concentrations in dogs with MMVD.

ANIMALS
74 dogs (control, n = 12; MMVD, n = 62) were included.

METHODS
Serum Ang-1 and Ang-2 concentrations were estimated using the canine-specific ELISA kit. The concentrations were compared between dogs with MMVD and healthy dogs, and they were analyzed according to the severity of MMVD and PH.

RESULTS
The median serum Ang-1 concentration did not differ among the study groups. The median serum Ang-2 concentration was higher in dogs with stage B2 MMVD (P = .041) and acute congestive heart failure (P = .002) than in control dogs. In addition, the median serum Ang-2 concentration was higher in MMVD dogs with PH than in those without PH (P = .031). Serum Ang-2 concentration was correlated with vertebral heart score (rs = 0.36, P = .004) and vertebral left atrial score (r = 0.50, P < .001) in dogs with MMVD, and correlated with vertebral heart score (r = 0.63, P = .01), maximum E wave amplitude of the diastolic transmitral flow (rs = 0.61, P = .018), ejection fraction (rs = –0.77, P < .001) and fractional shortening (rs = –0.56, P = .032) in dogs with acute congestive heart failure.

CLINICAL RELEVANCE
Circulating Ang-2 levels increase in dogs with the severity of MMVD and the presence of PH.
The Role of Hypothyroidism in the Etiology of Hyponatremia - Case Report and a Short Review
Authors: Anghel Lucretia , Baroiu Liliana , Stefanopol Ioana Anca , Busila Camelia , Ignat Daniela Mariana , Spalatelu Oana , Bulza Valentin 
Published: March 2024

Abstract
Hyponatremia induced by hypothyroidism is a rare phenomenon and a correlation between them can be argued only with possible mechanisms. Hyponatremia often results from the concomitant development of several overlapping pathological events. The association between hypothyroidism and hyponatremia should be considered only if explanations for any other etiological causes have been exhausted. We present the case of a female patient aged 67 years who has previously undergone surgery for a meningioma and who presented with symptoms such as nausea, biliary vomiting, headache and epigastric pain. Laboratory results indicated multiple electrolyte imbalances, including hyponatremia, but the brain imaging studies did not confirm cerebral edema or the presence of tumor development. Under electrolytic correction treatment which was supplemented with L-thyroxine, the biochemical parameters were corrected and normalized and the patient was relieved of her symptoms. This case thus raises the possibility that hyponatremia could be induced or at least precipitated by hypothyroidism. Thyroid dysfunction tests should be targeted in cases of hyponatremia with non-specific causes, even if hypothyroidism is rarely the cause.
Empowerment in chronic wound care—exploring the scope for patient contribution†
Authors: Hackert Benedikt , Stürmer Ewa Klara , Weger Ulrich 
Published: March 2024

Abstract

Objective
In this study, we investigated the concept of empowerment in chronic wound care and propose to facilitate patient control by making use of degrees of freedom (DOF): that is, shaping of everyday wound care tasks initiated by patients and based on their wishes, mostly in terms of patients executing treatment steps, requesting or directing health care professionals to undertake changes, or modifications of internal states.

Methods
As a first step, we conducted a systematic literature search, followed by an inductive form of qualitative content analysis, which resulted in the identification of 5 dimensions as main elements of empowerment: education and shared decision making, adherence to self-care behaviors, responsibility and control, general call for empowerment, and DOF. However, the latter are noticeably absent in the literature. To investigate patients’ freedom in shaping the wound care process, we conducted a second literature search.

Results
A number of possibilities for patients to influence the wound care process could be identified, but experimental or clinical evidence about their effects is missing, their variety is limited, and they are only inadequately described.

Conclusions
However, DOF should be an indispensable aspect of genuine empowerment, since they allow patients to occupy the role of the agent in the treatment process and give rise to the subjective experience of feeling empowered. Thus, in the third part, we develop a research proposal on how to investigate and include DOF in the clinical practice of wound care. Finally, limitations about implementations are discussed (e.g., patients being reluctant to overcome their passive role, resulting in frustration for health care professionals).
Irregular dietary habits as a predictor of stunting occurrence among children under 5 years of age: a literature review
Authors: Risnah  , Huriati  , Hadrayani Eka , Arbianingsih  , Muthahharah  , Nurhidayah  , Purwanti Sally 
Published: March 2024

Abstract

Objective
To identify the illustration of feeding patterns of stunting children using literature review method.

Methods
This study was a descriptive narrative research using literature review approach to explore dietary habits of children with stunting problem. All the literature review processes employed Guideline Review measurement of Joanna Briggs Institute. Related articles in literature were obtained from journal databases, such as PubMed, ScienceDirect, Google Scholar, and Dimensions through structured research question with Patient, Exposure an interest, Outcome or response (PEO) methods.

Results
This study found 2246 published articles from 2018 to 2021 about children with stunting. Screening process was conducted further to eliminate articles with irrelevant titles and abstracts, and also the unsuitable articles with the research question; hence, about 9 articles were eligible to be reviewed ahead. All these articles mentioned that children with irregular dietary habits would likely experience stunting. The low intake of nutritional food became the major predictor of stunting.

Conclusions
Inappropriate feeding patterns and the variety of food were being the factors of stunting emergence among children <5 years of age. High consumption of carbohydrates, less animal-based protein, and misunderstanding about intake of sweetened-condensed milk predisposed children to suffer stunting.
Nursing student volunteers and their level of involvement during the COVID-19 pandemic: a systematic review
Authors: Fithriyyah Yayu Nidaul , Alim Syahirul 
Published: March 2024

Abstract

Objective
Many strategic efforts were made to address nurses’ shortage in controlling Coronavirus disease 2019 (COVID-19), including recruiting student health volunteers. This review aimed to explore the contribution and involvement of nursing student volunteers during COVID-19.

Methods
A systematic review was registered in PROSPERO International CRD42021283069. Electronic databases for article search included: SCOPUS, EBSCO MEDLINE, PubMed, ProQuest, Springer, Sage Pub, and hand searching. The critical appraisal study quality using The Joanna Briggs Institutes. Data extraction and synthesis used Population, Intervention, Comparison, Outcome, and Design (PICO and D) framework with thematic analysis.

Results
Twelve studies were enrolled from 2545 retrieved, with 4 synthesized themes: (1) determinant of the involvement of nursing student volunteers during COVID-19, which includes 3 subthemes: motivations, perception, and barriers, (2) expectations and actual condition of nursing students as volunteers, (3) the need for nursing student volunteers, and (4) the impact and level of student volunteers’ contribution. All student volunteers contribute to providing direct or indirect services to patients.

Conclusions
This review provides an overview of nursing student volunteers’ needs useful in developing competency frameworks and the role of culturally sensitive volunteers in education and training. In the future, student volunteers could choose the appropriate volunteer program and location according to their competence.