bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preparation and characterization of multipurpose polypropylene composite with outstanding flame retardancy and antistatic property
Authors: Zhan Zhaoshun , Shen Jinfeng , Du Chao , Shi Qixing , Bao Tianyou , Weng Shihan , Li Lilin 
Published: February 2024

AbstractTo enhance the safety grade and broaden the application scope of polypropylene in coal mines, the calcium alginate@ammonium polyphosphate@graphite microsheet (CA@APP@GM) had been synthesized and introduced into the polypropylene (PP) material to endow excellent flame retardancy, antistatic characteristics, thermostability, combustion behavior, and mechanical performance. Physical characterizations on the chemical composition and microstructure of both the gaseous and condensed phase products indicated that the phosphorus‐containing compounds were found in the char residue which were beneficial to accelerate the charring reaction to terminate the mass and heat transfer process. Hence, the CA@APP@GM executed the condensed‐phase flame‐retardant mechanism to enhance the fire resistance of PP matrix. Consequently, it is believed that the CA@APP@GM, with its remarkable flame retardancy and antistatic properties, has the potential to significantly expand the range of applications for PP materials in coal mines.
Role of HFSCARC in hair follicle stem cell proliferation and differentiation in cashmere goat
Authors: Wang Niu , Zhang Weidong , Guo Yi , Zhang Fan , Zhang Tongtong , Wang Xin 
Published: February 2024

AbstractAs a model of regenerative medicine, hair follicle stem cell (HFSC) plays a determining role in the hair cycle. Emerging evidences showed that long noncoding RNAs regulated the biological function of HFSC. In this current study, we found that lncRNA‐000552, standing for “goat secondary HFSC Associated SYNE3 Regulator of HF Cycle” (HFSCARC) expressed higher in anagen than that in telogen of cashmere goat. Through experiments involving nucleocytoplasmic separation and RNA‐FISH, we determined that HFSCARC was primarily located in the nucleus of HFSC. To understand the function of HFSCARC, the study performed various assays, including crystal violet staining, 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide, EdU, and flow cytometry analysis, which collectively revealed that HFSCARC inhibited HFSC proliferation. Additionally, HFSCARC promoted the differentiation of HFSC by investigating the expression of marker genes specific to stem cells and keratinocytes. RNA sequencing analysis was conducted to investigate the global gene expression changes associated with HFSCARC expression. The results showed that HFSCARC altered the expression of genes involved in cell proliferation, hair follicle development, and regulation of bone morphogenetic proteins (BMP) signaling. Furthermore, the study revealed that HFSCARC activated the BMP signaling pathway. Intriguingly, the study found a decreased expression of SYNE3, which was a neighboring gene of HFSCARC. The altered expression of genes associated with transmethylase and demethylase further suggested that HFSCARC might play an important role in regulating the SYNE3 expression. Overall, this study provides valuable insights into the regulatory role of HFSCARC in the biological function of HFSC. These findings contribute to a better understanding of the involvement of noncoding RNAs in the regulation of hair cycle.
A new injection method for identifying the subpopliteal recess of the knee
Authors: Tabira Yoko , Yamashita Akihiro , Kikuchi Keishiro , Han Aya , Shimizu Keigo , Harano Tatsuya , Haikata Yuto , Inoue Eiko , Nooma Kunimitsu , Iwanaga Joe , Saga Tsuyoshi , Watanabe Koichi 
Published: February 2024

AbstractThe posterolateral region of the knee has a complex and diverse anatomy. Hydrarthrosis of the knee can potentially communicate with other parts of the joint space. The joint fluid distribution reflects anatomical communications between synovial spaces. To observe the continuity between the knee joint cavity and the surrounding bursa, we devised a dissection method with a new injection agent, an eosin‐containing congealed liquid that spreads uniformly over the entire space. The purpose of this study was to perform a detailed examination of the subpopliteal recess (SPR) where a bursa connects to the knee joint capsule. We also reported the advantages of this new injection agent compared with conventional materials (latex and epoxy resin). Twenty‐two formalin‐fixed cadavers (34 knees), two N‐vinyl‐pyrrolidone (NVP)‐fixed cadavers (4 knees), and two cadavers (3 knees) fixed by Thiel's method were used. After filling the knee joint space and SPR with eosin congealed liquid, the specimens were dissected to investigate the morphology of the SPR. In addition, three different types of injection agents were assessed. The SPR extended distally along the popliteus tendon. The SPR length was 22.64 ± 11.38 mm from the upper end of the lateral tibial condyle to the lower end of the depression. The existence of a fabellofibular ligament made the SPR significantly longer, but abrasion of the femoral articular cartilage did not affect the SPR. Furthermore, the relationship between the popliteus muscle and the SPR was classified into three types (types 1–3). Types 2 and 3 in which the SPR extended to the proximal tibiofibular joint may cause instability of the knee joint. The eosin congealed liquid was highly useful in many aspects, such as fluidity and injection workability. The new dissection method with eosin congealed liquid provides insights into the anatomy of the posterior lateral knee, which are useful for radiological diagnoses and clinical treatments.
Effect of Strong CYP3A4 Inhibition, CYP3A4 Induction, and OATP1B1/3 Inhibition on the Pharmacokinetics of a Single Oral Dose of Sotorasib
Authors: Cardona Panli , Dutta Sandeep , Houk Brett 
Published: February 2024

AbstractSotorasib is a small molecule that irreversibly inhibits the Kirsten rat sarcoma viral oncogene homolog (KRAS) protein with a G12C amino acid substitution mutant protein. The impact of cytochrome P450 (CYP) 3A4 inhibition and induction on sotorasib pharmacokinetics (PKs) was evaluated in 2 separate studies in healthy volunteers (N = 14/study). The impact of CYP3A4 inhibition was interrogated utilizing repeat doses of 200 mg of itraconazole, a strong CYP3A4 inhibitor, on 360 mg of sotorasib PKs. The impact of CYP3A4 induction was interrogated utilizing multiple doses of 600 mg of rifampin, a strong CYP3A4 inducer. Additionally, the impact of organic anion transporting polypeptide (OATP) 1B1/3 inhibition on 960 mg of sotorasib PKs was interrogated after a single dose of 600 mg of rifampin. CYP3A4 inhibition did not significantly impact sotorasib Cmax but did lead to a 26% increase in sotorasib AUCinf. CYP3A4 induction decreased sotorasib Cmax by 35% and AUCinf by 51%. OATP1B1/3 inhibition decreased sotorasib Cmax and AUCinf by 16% and 23%, respectively. These results support that sotorasib can be given together with strong CYP3A4 and OATP1B1/3 inhibitors but the co‐administration of sotorasib and strong CYP3A4 inducers should be avoided.
Low‐intensity pulsed ultrasound induces proliferation of human neural stem cells
Authors: Al‐Maswary Arwa A. , Walmsley A. Damien , Cooper Paul R. , Scheven Ben A. 
Published: February 2024

AbstractBackgroundLow‐intensity pulsed ultrasound (LIPUS) has been highlighted as a potential therapy for tissue repair and regeneration. However, little is known about LIPUS effects on neuromodulation. This research was conducted to study LIPUS effect on the proliferation of human neural stem cells.Materials and methodsThe human SH‐SY5Y neuroblastoma cell line was used as a neural stem cell model. The well‐documented SH‐SY5Y neurogenic protocol, which involves treatment with all trans‐retinoic acid (ATRA) for 5 days and then brain‐derived neurotrophic factor (BDNF) for 7 days, was used to synchronise the growth cell cycle to G1 phase of the cell cycle before proliferation testing. Subsequently, the neural stem cells were then treated with single or triple 20‐min LIPUS exposures (Intensity ISATA: 60 mW/cm2, frequency: 1.5 MHz, pulse repetition: 100 Hz, and duty cycle: 20%). Cell proliferation was analysed using cell counting of β‐tubulin and neurofilament medium‐positive neural stem cells, Ki67‐cell proliferation marker and metabolic‐based assays (cell counting kit‐8 and alamarBlue). The involvement of ERK signalling was investigated by quantification of phospho‐ERK1/2 levels and cell proliferation with and without MEK/ERK inhibitor (U0126).ResultsThe results show that LIPUS exposure(s) induced cell proliferation, as evidenced by an increase in the numbers of neural stem cells. ERK signalling is involved in LIPUS‐induced neural stem cell proliferation, as evidenced by concurrent inhibition of LIPUS‐induced phospho‐ERK levels and cell proliferation in the presence of the MEK/ERK inhibitor.ConclusionThis study provides original evidence that LIPUS can stimulate neural stem/progenitor cell proliferation. LIPUS may be suggested as a sole or an adjunct therapeutic application to promote the neural stem cell pool in stem cell therapies and tissue engineering approaches for nerve repair and regeneration for the management of traumatic nerve injuries and regenerative endodontic treatment.
Passive reputation method with hybrid optimized deep model for spectrum sensing in cognitive radio network based on blockchain
Authors: Dewangan Neelam , Kumar Arun , Patel Ram Narayan 
Published: February 2024

SummaryThe discovery of malevolent users in cognitive radio networks (CRNs) is done by using blockchain‐based technique. For diagnosing the availability of frequency resources, the spectrum sensing (SS) plays an essential role in CRN. It is critical to enable cognitive radio (CR) technology in wireless communication systems for the next generation. Due to the increasing demand of the users, some bands are overloaded and others become underutilized. The CR applied models for vigorously assigning unlicensed users. The missed detection problem occurs in the conventional spectrum sensing schemes, which hampers the proper utilization of the spectrum. These motivated the development of a newly devised passive reputation method with an optimized deep model for spectrum sensing in CRN‐based blockchain. The sensing spectrum in CRN is designed using the cooperative spectrum sensing algorithm. The spectrum sensing is done with the decision made using AlexNet where the weights of AlexNet are trained with a hybrid optimization algorithm, named Honey Badger Remora Optimization (HBRO) algorithm. Thus, the output attained from the Alexnet_HBRO algorithm is considered. Meanwhile, the data are recorded in the blockchain, and then, the passive reputation is performed, and the determined output is considered. At last, the spectrum sensing is carried out by fusing AlexNet and passive reputation output where weights are optimally generated using the proposed Snake Honey Badger Remora Optimization (SHBRO) algorithm. The proposed SHBRO offered a high detection probability of 1, false alarm probability of 0.003, sensing time of 551.567s, and computation time of 210.102s.
Cp2Fe‐Mediated Electrochemical Synthesis of Functionalized Compounds: Recent Advances
Authors: Zhu Ranran R. , Ma Dumei M. , Zhao Yufen F. , Wu Ju 
Published: February 2024

AbstractUnlike traditional organic methods, electrosynthesis has emerged as an environmentally friendly and sustainable approach to generate a series of functionalized compounds. In this process, the traceless electron serves as the redox agent, eliminating the need for stoichiometric oxidants or reductants. In contrast to direct electrolysis, redox‐mediated electrolysis has the ability to overcome kinetic inhibitions and achieve diverse selectivity under mild conditions. This has garnered increasing attention from the synthetic community, especially in the past few years. This review will focus on Cp2Fe‐mediated electrosynthesis of diversified functionalized compounds through C−N, C−C, C−P and C−O bond formation over the past decade.
Determining sediment deposition dynamics influenced by check dams in a semi‐arid mountainous watershed
Authors: Polyakov Viktor , Nichols Mary , Cavanaugh Michelle 
Published: February 2024

AbstractSemi‐arid environments are characterized by infrequent large magnitude rainfalls that produce flash flood events with high sediment concentration. Control structures such as check dams are widely used in this environment for mitigation. However, their impact on the overall sediment balance of watersheds, particularly those severely affected by anthropogenic activity, is sparsely documented. This study used topographic measurements, sediment analysis, and fallout isotope techniques to assess the effectiveness and service life of 18 rock and masonry check dams that were constructed in the 1930s for controlling sediment fluxes in an 11 ha mountainous watershed in southern Arizona. All of the dams are currently filled with sediment resulting in reduction of local channel gradients by 35 to 71% to between 0.04 and 0.28 depending on location within the reach. Sedimentation occurred over multiple decades at a relatively slow average rate of 0.59 t ha−1 y−1 indicating low instantaneous retention efficiency. The smaller headwater dams were filled soon after construction; however, their share of the overall storage capacity was minor. Although evaluation of 137Cs was an effective method for dating sediment, the 210Pb dating method was not satisfactory because of sediment sorting effects and complex deposition patterns. The abundance of similar control structures in the region points to the opportunity to better understand the process impacts of check dams over multiple decades to inform planning and design of their use in future mitigation projects.
Does one size fit all? The role of job characteristics in cultivating work passion across knowledge, blue‐collar, nonprofit, and managerial work
Authors: Astakhova Marina N. , McKay Alexander S. , Doty D. Harold , Wooldridge Barbara R. 
Published: February 2024

AbstractWe integrate the job characteristics and dual work passion models to explore the indirect (via work meaningfulness) effects of job characteristics (i.e., job autonomy, task identity, skill variety, task significance, feedback from the job and feedback from others) on two types of work passion, harmonious passion (HP) and obsessive passion (OP). We first advance occupation‐specific predictions for job characteristics‐to‐work passion relationships and then explore differences in those relationships between HP and OP across four occupational sectors: knowledge work (n = 201), blue‐collar work (n = 148), nonprofit work (n = 141), and managerial work (n = 133). Our findings demonstrate that job characteristics are important drivers of work passion. However, our key discovery is that the motivational impact of the job characteristics is not universally applicable but rather depends on the specific occupational context and whether passion is harmonious or obsessive. We therefore conclude that when it comes to translating job characteristics into work passion, the one‐size‐fits‐all approach is not appropriate.
Effects of presidential elections on accounting conservatism: Evidence from South Korea
Authors: Kim Sang Ho , An Yohan 
Published: February 2024

AbstractThis study examines the effects of presidential elections (PEs) on firms’ accounting conservatism in Korea. The Korean president exerts great influence on the government's financial, monetary, subsidiary, and regulatory policies. At the same time, however, the Korean constitution prohibits the re‐election of the incumbent president. This simultaneously strong and fragile presidential system creates unique political uncertainty, which deteriorates the information gap between firms’ insiders and outsiders. According to the efficient contracting channel, accounting conservatism is expected to relieve information asymmetry by recognizing the economic losses faster than economic gains. But we posit that the effectiveness of accounting conservatism depends on the information environment within which they operate. If the information environment facilitates a compensation system for an increase in accounting conservatism under high uncertainty, managers may prefer to expand conservative accounting practices. However, if there is no such incentive mechanism, managers may opt to suspend accounting conservatism because the cost of revealing bad news increases during periods of uncertainty. Test results show that PEs encourage managers to delay rather than expedite the timely recognition of economic losses. This negative effect becomes more pronounced in firms with higher reliance on government contracts than firms with lower such reliance. We also find that Korean chaebol‐affiliated firms are likely to increase accounting conservatism during PEs. In general, US‐based studies support the positive relationship between information asymmetry and accounting conservatism, while this study demonstrates that this relationship can be reverse depending on the institutional environment.
How early environment influences the developing brain and long‐term mental health
Authors: Sprooten Emma 
Published: February 2024

AbstractThe March 2024 issue of JCPP Advances features two neuroimaging studies that investigate links between early environmental risk factors for mental health problems, brain development and psychopathology in children and young adults. The papers provide new insights into how adverse environments and negative experiences in childhood increase risk for depression and mental health problems, and how this may or may not be mediated, or moderated, by individual differences in the brain.
A review of the development and implementation of the critical source area concept: A reflection of Andrew Sharpley's role in improving water quality
Authors: McDowell Richard , Kleinman Peter J. A. , Haygarth Philip , McGrath Joshua M. , Smith Douglas , Heathwaite Louise , Iho Antti , Schoumans Oscar , Nash David 
Published: February 2024

AbstractCritical source areas (CSAs) are small areas of a field, farm, or catchment that account for most contaminant loss by having both a high contaminant availability and transport potential. Most work on CSAs has focused on phosphorus (P), largely through the work in the 1990s initiated by Dr. Sharpley and colleagues who recognized the value in targeting mitigation efforts. The CSA concept has been readily grasped by scientists, farmers, and policymakers across the globe. However, experiences and success have been mixed, often caused by the variation in where and how CSAs are defined. For instance, analysis of studies from 1990 to 2023 shows that the proportion of the annual contaminant load coming from a CSA decreases from field to farm to catchment scale. This finding is consistent with increased buffering of CSAs and greater contribution of other sources with scale, or variation in the definition of CSAs. We therefore argue that the best application of CSAs to target mitigation actions should be at small areas that truly account for most contaminant loss. This article sheds light on the development and utilization of CSAs, paying tribute to Dr. Sharpley's remarkable contributions to the improvement of water quality, and reflecting upon where the CSA concept has succeeded or not in reducing contaminant (largely P) loss.
Postoperative intravenous patient‐controlled analgesia improves pain management after subcutaneous implantable defibrillator implantation
Authors: Tsutsui Kenta , Terazaki Yoshitaka , Kanai Risa , Ishii Masako , Ohno Seika , Sasaki Yoko , Kitamura Akira , Kudo Daisuke , Sasaki Wataru , Tanaka Naomichi , Narita Masataka , Matsumoto Kazuhisa , Mori Hitoshi , Ikeda Yoshifumi , Arai Takahide , Nakano Shintaro , Kato Ritsushi 
Published: February 2024

AbstractObjectivePostoperative pain is a major issue with subcutaneous implantable cardioverter defibrillators (S‐ICD). In 2020, we introduced intravenous patient‐controlled analgesia (IV‐PCA) in addition to the conventional, request‐based analgesia for postoperative pain control in S‐ICD. To determine the effect and safety, we quantitatively assessed the effect of IV‐PCA after S‐ICD surgery over conventional methods.MethodsDuring the study period, a total of 113 consecutive patients (age, 50.1 ± 15.5 years: males, 101) underwent a de novo S‐ICD implantation under general anesthesia. While the postoperative pain was addressed with either request‐based analgesia (by nonsteroid anti‐inflammatory drugs, N = 68, dubbed as “PCA absent”) or fentanyl‐based IV‐PCA in addition to the standard care (N = 45, dubbed as “PCA present”). The degree of postoperative pain from immediately after surgery to 1 week were retrospectively investigated by the numerical rating scale (NRS) divided into four groups at rest and during activity (0: no pain, 1–3: mild pain, 4–6: moderate pain, 7–10: severe pain).ResultsAlthough IV‐PCA was removed on Day 1, it was associated with continued better pain control compared to PCA absent group. At rest, the proportion of patients expressing pain (mild or more) was significantly lower in the PCA present group from Day 0 to Day 4. In contrast to at rest, a better pain control continued through the entire study period of 7 days. No serious adverse events were observed. A few patients experienced nausea in both groups and the inter‐group difference was not found significant.ConclusionIV‐PCA suppresses postoperative pain in S‐ICD without major safety concerns.
Wideband filtering power dividers with/without notch band
Authors: Gorur Ali Kursad , Dogan Engin , Karpuz Ceyhun , Gorur Adnan 
Published: February 2024

AbstractLow loss and compact wideband filtering power dividers (WB‐FPDs) with/without notch band are proposed. The WB‐FPDs are designed using wideband bandpass filter based on asymmetric stepped‐impedance resonator (SIR). Parallel coupled microstrip lines are used to create both wideband filtering characteristic and two additional transmission poles. A notch band can be generated at upper passband edge by using open‐circuited stubs on the SIRs. The WB‐FPDs with/without notch band are successfully designed, fabricated, and tested. The wide passband is centered at 4 GHz with the fractional bandwidth (FBW) of 51.1%, while the notch band is at 5.56 GHz with the FBW of 3.1%. Good agreement between the simulated and measured results is observed.