bluuebunny/crossref_metadata_2025_split huggingface dataset:
- Auditor’s Integrity: The Balance of Roles
Authors: Fibriani Rudiana 
Published: April 2024

Auditor integrity is very important to ensure audit quality. However, auditor integrity can be influenced by pressure from superiors such as role conflict, role ambiguity, and role overload. This study aims to examine the effect of the three role pressure factors on auditor integrity and performance. This quantitative research with a causality approach was conducted through Google Form by involving staff auditors who work for 52 KAPs in Surabaya. Then the primary data was analyzed using SmartPLS. The results show that role conflict and role ambiguity have a significant negative effect on auditor integrity, while role overload has a positive but insignificant effect. Auditor integrity significantly negatively mediates the effect of role conflict and role ambiguity on auditor performance, and significantly positively mediates the effect of role overload on auditor performance. This study concludes that role pressure can threaten auditor integrity, so steps need to be taken to reduce pressure so that auditors can maintain their integrity.

Keywords: Role Conflict, Role Ambiguity, Role Overload, Auditor Integrity, Auditor Performance.
COMPARATIVE ANALYSIS OF STOCK PORTFOLIO RISK & RETURN”WITH SINGLE INDEX METHOD
Authors: Pandin Maria Yovita R 
Published: April 2024

This study aims to compare the return and risk of investment in blue chip stocks (first liner) and second liner stocks of manufacturing companies listed on the Indonesia Stock Exchange (IDX) during the 2022 period. The method used is qualitative with single index theory, and closing price data is used for analysis. The results show that a portfolio of second liner stocks provides higher expected returns and lower risk compared to first liner stocks. Nonetheless. This research provides insights for investors and the public about the investment alternatives of first liner and second liner stocks, and shows the importance of portfolio diversification in managing investment risk. Future research can expand the scope of industry sectors and other analytical methods to explore a deeper understanding of stock investment on the IDX.
НАУКОВІ ДОСЛІДЖЕННЯ З ФІЗИЧНОЇ КУЛЬТУРИ І СПОРТУ В УКРАЇНІ З 2014 Р.
Authors: ВНУКОВА Ольга , ТОМІЧ Лілія 
Published: April 2024

У статті здійснено аналіз вітчизняних наукових досліджень з фізичної культури і спорту у період російської агресії щодо України з 2014 р. Охарактеризовано основну проблематику фахових наукових видань України категорії «А» та «Б» зі спеціальності 017 «Фізична культура і спорт». На основі проведеного аналізу авторефератів дисертацій з тем фізичної культури і спорту визначено особливості та напрями наукових пошуків. Відмічено, що цих тем стосувалися і роботи суміжних галузей знань та спеціальностей: педагогіки, філософії, соціології, права, управління, біології та ін. Найбільше було захищених дисертацій до 2020 р. зі спеціальності 24.00.02 «Фізична культура, фізичне виховання різних груп населення», найменше з 24.00.03 «Фізична реабілітація». Тобто, було приділено недостатньо уваги питанням фізичного виховання осіб із відхиленням у стані здоров'я. Зі спеціальності 017 «Фізична культура і спорт» з 2020 р. здійснювались дослідження за напрямками: підготовка спортсменів, види спорту, фітнес і рекреація, фізична підготовка школярів, студентів, військових. Хоча в останні роки зменшилась кількість праць із фізичного виховання школярів та студентів, але звертається більша увага на оздоровчий фітнес та рекреацію.
Обґрунтовано потребу вдосконалення змісту наукових досліджень на сучасному етапі, як важливої передумови реформування сфери фізичної культури і спорту в Україні. Ситуація війни передбачає зміщення акценту на фізичну підготовку молоді, яка була б готова до оборони України, їх патріотичне виховання під час фізичного виховання та занять спортом.
Transformasi Digital Sebagai Strategi Kenusantaraan Warisan Budaya: Studi AI Pada Kereta Kencana Paksi Naga Liman
Authors: Wibawa Mahendra , Sunarmi Sunarmi , Soewarlan Santosa 
Published: April 2024

Tujuan dari artikel ini adalah untuk meneliti bagaimana Kecerdasan Buatan (AI) menggunakan Dall-E, dapat menginterpretasi kembali artefak budaya, memberikan perspektif baru dalam visualisasi dan pemahaman Sejarah tentang Kereta Kencana Paksi Naga Liman. Metodologi penelitian ini melibatkan pengumpulan data dari sudut pandang etik dan emik, yang kemudian digunakan untuk menginstruksikan AI dalam menghasilkan visualisasi baru. Selain itu pengumpulan data juga dilakukan dengan wawancara tidak terstruktur pada pramu wisata yang bertugas. Hasil penelitian ini menghasilkan sejumlah kata kunci yang dapat dijadikan prompt untuk AI, serta berbagai contoh hasil visual yang dihasilkan oleh AI berdasarkan kombinasi prompt tersebut. AI dapat merespon dan mereinterpretasi artefak budaya ini, memberikan dimensi baru pada pengalaman visual dan pemahaman sejarah
Sistemas dinámicos en psicología: una aproximación conceptual al estudio de la comunicación emocional
Authors: Estévez Ceballos José Areth 
Published: April 2024

El proceso de comunicación entre madre-bebé se caracteriza por un intercambio recíproco de emociones, sensaciones, y afectos que se evidencian en diferentes repertorios de interacción en los que emergen respuestas que se expresan en una gran variedad de formas, a saber: el cruce de miradas, las caricias, sonrisas y demás movimientos corporales. La emergencia de estas respuestas emocionales se ha estudiado mediante escalas de medición temporal en tiempo real y en tiempo de desarrollo. La evidencia empírica muestra cómo durante este proceso aparecen emociones en la comunicación madre – bebé que seguirán patrones de estabilidad y transformación. El presente documento presenta una revisión de literatura sobre sistemas dinámicos en psicología y su relación con la comunicación emocional en la diada durante los primeros meses de vida del infante.
Propuesta de modelo matemático del rendimiento de mano de obra en porcelanato en pisos. Caso de estudio: ciudad de Cuenca
Authors: Lucero Bonilla Jorge Fabián , Calle Castro Carlos Julio , Mendoza Enríquez Nayra 
Published: April 2024

Introducción. El rendimiento de mano de obra en la actividad de colocación de porcelanato en piso es clave para una eficiente planificación de proyectos constructivos. Sin embargo, aún hoy, la planificación de este rendimiento no se realiza de manera técnica y se asume la linealidad en los resultados, sin considerar la variabilidad de este rendimiento en función de factores externos e internos de los obreros. Objetivo. Proponer un modelo matemático para predecir el rendimiento de la mano de obra en la instalación de porcelanato en pisos en la ciudad de Cuenca, específicamente en la parroquia Machángara. Metodología. Se realizó una revisión de la literatura relacionada con los factores que influyen en el rendimiento de los obreros en esta actividad. A partir de esta información, se diseñó una ficha de observación que incluyó 6 variables y 35 indicadores relevantes. Se aplicó una metodología descriptiva de tipo correlacional con enfoque cuantitativo, recolectando datos de una muestra de 5 edificaciones en fase de colocación de porcelanato. Resultados. Los resultados, analizados estadísticamente, revelaron una eficacia del 98% del modelo propuesto en relación con el rendimiento real de los trabajadores. Además, se evidenció que, en Machángara, los rendimientos de los obreros se sitúan por debajo del estándar teórico proporcionado por el GAD de Cuenca. Conclusión. Se concluye que los modelos matemáticos basados en los factores estudiados son capaces de predecir con precisión el rendimiento de los obreros, lo que puede mejorar las predicciones y tiempos de ejecución de los gestores de obra.
Factores psicosociales que afectan a los trabajadores en una empresa procesadora de alimentos de Cuenca
Authors: Loayza Romero Amparo del Rocío , Andrade Campoverde Diego Paul , Quinde Alvear Ángel Giovanny 
Published: April 2024

Introducción. Los factores psicosociales existentes dentro del ámbito laboral son diversos y están conformados por aquellos aspectos como el ambiente físico, estructura institucional y las relaciones interpersonales en las organizaciones. Objetivo. identificar los factores psicosociales que afectan a los empleados en una empresa procesadora de alimentos de la ciudad de Cuenca, en las áreas de administración, almacenamiento y entrega. Metodología. Se realizó un estudio transversal, cuantitativo, descriptivo, mediante la aplicación del cuestionario CoPsoQ-istas21 versión 2; el número de encuestados (44) se determinó mediante el formulario de muestreo (Krejcie y Morgan). Se utilizaron variables laborales como horario, salud, cargo, reconocimiento salarial y demográfico como el sexo y la edad. Los datos se recolectaron a través de hojas de cálculo y se analizaron a través del programa estadístico SPSS versión 26. Resultados. La satisfacción laboral es más alta entre los mayores de 45 años, con un 43.75% muy satisfechos. En general, hay una tendencia positiva hacia la satisfacción laboral en todos los grupos de edad. Conclusión. En resumen, los datos sugieren que la satisfacción laboral tiende a aumentar con la edad, siendo más pronunciada entre aquellos mayores de 45 años. Sin embargo, en general, la mayoría de los encuestados, independientemente de su edad, se encuentran satisfechos o muy satisfechos con su trabajo, lo que indica un nivel generalizado de satisfacción laboral en la muestra estudiada. Área de estudio general: Medicina del trabajo. Área de estudio específica: Salud ocupacional
Jättääkö tehokkuusajattelu tilaa yhteiskunnan uudistumisen tarpeille?
Authors: Yli-Viikari Anja 
Published: April 2024

Tehokkuusajattelu voi muodostua jopa jarruksi, kun työelämä vaatii systeemistä kehittämistä muutoksiin vastaamiseksi. Työn arjessa tehokkuusajattelun ja systeemisen uudistumisen näkökulmat limittyvät ja vahvistavat toisiaan, mutta niiden erilainen luonne on syytä tunnistaa, jotta organisaation toimintakulttuuri ei vinoudu kummankaan suuntaan. Kun siirrytään tehokkuusajattelusta laaja-alaisempaan systeemiseen uudistumiseen niin tiedollisia rakenteita kuin organisaatiokulttuuria ja toimijoiden välistä vuorovaikutusta koskevat toimintatavat muuttuvat.
Synthetic protein protease sensor platform
Authors: Devoy Ciaran , Flores Bueso Yensi , Buckley Stephen , Walker Sidney , Tangney Mark 
Published: April 2024

Introduction: Protease activity can serve as a highly specific biomarker for application in health, biotech, and beyond. The aim of this study was to develop a protease cleavable synthetic protein platform to detect protease activity in a rapid cell-free setting.Methods: The protease sensor is modular, with orthogonal peptide tags at the N and C terminal ends, which can be uncoupled via a protease responsive module located in between. The sensor design allows for several different readouts of cleavage signal. A protein ’backbone‘ [Green fluorescent protein (GFP)] was designed in silico to have both a C-terminal Flag-tag and N-Terminal 6x histidine tag (HIS) for antibody detection. A protease cleavage site, which can be adapted for any known protease cleavage sequence, enables the uncoupling of the peptide tags. Three different proteases—Tobacco, Etch Virus (TEV), the main protease from coronavirus SARS-COV-2 (Mpro) and Matrix Metallopeptidase 9 (MMP9)—a cancer-selective human protease—were examined. A sandwich Enzyme-Linked Immunosorbent Assay (ELISA) was developed based on antibodies against the HIS and Flag tags. As an alternative readout, a C-terminal quencher peptide separable by protease cleavage from the GFP was also included. Purified proteins were deployed in cell-free cleavage assays with their respective protease. Western blots, fluorescence assays and immunoassay were performed on samples.Results: Following the design, build and validation of protein constructs, specific protease cleavage was initially demonstrated by Western blot. The novel ELISA proved to afford highly sensitive detection of protease activity in all cases. By way of alternative readout, activation of fluorescence signal upon protease cleavage was also demonstrated but did not match the sensitivity provided by the ELISA method.Discussion: This platform, comprising a protease-responsive synthetic protein device and accompanying readout, is suitable for future deployment in a rapid, low-cost, lateral flow setting. The modular protein device can readily accommodate any desired protease-response module (target protease cleavage site). This study validates the concept with three disparate proteases and applications–human infectious disease, cancer and agricultural crop infection.
Vaginal microbiota molecular profiling and diagnostic performance of artificial intelligence-assisted multiplex PCR testing in women with bacterial vaginosis: a single-center experience
Authors: Lu Sihai , Li Zhuo , Chen Xinyue , Chen Fengshuangze , Yao Hao , Sun Xuena , Cheng Yimin , Wang Liehong , Dai Penggao 
Published: April 2024

BackgroundBacterial vaginosis (BV) is a most common microbiological syndrome. The use of molecular methods, such as multiplex real-time PCR (mPCR) and next-generation sequencing, has revolutionized our understanding of microbial communities. Here, we aimed to use a novel multiplex PCR test to evaluate the microbial composition and dominant lactobacilli in non-pregnant women with BV, and combined with machine learning algorithms to determine its diagnostic significance.MethodsResidual material of 288 samples of vaginal secretions derived from the vagina from healthy women and BV patients that were sent for routine diagnostics was collected and subjected to the mPCR test. Subsequently, Decision tree (DT), random forest (RF), and support vector machine (SVM) hybrid diagnostic models were constructed and validated in a cohort of 99 women that included 74 BV patients and 25 healthy controls, and a separate cohort of 189 women comprising 75 BV patients, 30 intermediate vaginal microbiota subjects and 84 healthy controls, respectively.ResultsThe rate or abundance of Lactobacillus crispatus and Lactobacillus jensenii were significantly reduced in BV-affected patients when compared with healthy women, while Lactobacillus iners, Gardnerella vaginalis, Atopobium vaginae, BVAB2, Megasphaera type 2, Prevotella bivia, and Mycoplasma hominis were significantly increased. Then the hybrid diagnostic models were constructed and validated by an independent cohort. The model constructed with support vector machine algorithm achieved excellent prediction performance (Area under curve: 0.969, sensitivity: 90.4%, specificity: 96.1%). Moreover, for subjects with a Nugent score of 4 to 6, the SVM-BV model might be more robust and sensitive than the Nugent scoring method.ConclusionThe application of this mPCR test can be effectively used in key vaginal microbiota evaluation in women with BV, intermediate vaginal microbiota, and healthy women. In addition, this test may be used as an alternative to the clinical examination and Nugent scoring method in diagnosing BV.
Modeling the morphological response of gravel–bed rivers subject to repeated sediment bypass tunnel operations
Authors: Facchini Matteo , Vetsch David F. , Boes Robert M. , Siviglia Annunziato 
Published: April 2024

Introduction: Sediment bypass tunnels (SBTs) are operated during floods to re-establish sediment continuity past dams with the ultimate goal of decreasing accumulation in reservoirs. Depending on the location of the intake structure and operational conditions, SBTs may release either bed load-laden or bed load-free flows in the form of sudden floods (pulses). When evaluating the impacts of SBTs, the traditional approach has been to monitor channel changes in the years following project completion. However, by the time these impacts become evident, mitigation is challenging.Methods: This research adopts a forward-thinking methodology, emphasizing the prediction of potential impacts during the project’s early planning stages. We use a one-dimensional morphodynamic model to forecast the potential morphological response of a gravel-bed river with an idealized geometry to a series of SBT operations characteristic of projects in the Swiss Alps.Results: The morphological response of the downstream reach over the medium to long term is influenced by the alternating pattern of bed load-laden and bed load-free flow releases. This pattern is instrumental in forming a transition region near the SBT outlet hydrograph boundary layer (HBL).Discussion: Within the (HBL), fluctuations in bed elevation and slope are localized, while variations in grain-size distribution persist throughout the downstream region.
Early identification of golimumab-treated patients with higher likelihood of long-term retention
Authors: García-Dorta Alicia , González-Dávila Enrique , Sánchez-Jareño Marta , Cea-Calvo Luis , Pombo-Suárez Manuel , Sánchez-Alonso Fernando , Castrejón Isabel , Díaz-González Federico 
Published: April 2024

BackgroundThe early identification of patients’ profiles most likely to respond to and maintain long-term therapy with a biological drug can have clinical and cost-effectiveness implications.ObjectivesTo evaluate the utility of an innovative approach for early identification of patient profiles associated with long-term persistence of golimumab, a tumour necrosis factor inhibitor, in patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA), and axial spondyloarthritis (SpA) under real-world conditions.DesignRetrospective non-interventional database analysis.MethodsKaplan-Meier curves of golimumab retention over 8 years from the BIOBADASER registry, overall and by indication, were analysed using a novel approach (a two-phase decay model) to identify the point at which the golimumab retention curve shifted from rapid (indicating high golimumab discontinuation rate) to slow decay (low discontinuation rate). Factors associated with golimumab retention at these time points were identified using Cox regression, and retention rates for different patient profiles were calculated.Results885 patients were included. The golimumab retention curve shifted from rapid to slow decay at month 10 for the overall population (retention rate: 73.4%), at month 24 for RA patients (retention: 45.0%), and at month 8 for SpA, including axial SpA and PsA (81.6%). Factors associated with golimumab discontinuation at these early points were, overall, similar to those previously identified at year 8 (RA diagnosis, golimumab as second- or third-line of biological therapy, disease activity over the median and treatment with corticosteroids at golimumab initiation, advanced age [in RA], and female gender [in SpA]).ConclusionWith this novel approach, the factors associated with long-term retention were identified in the initial period of rapid discontinuation of golimumab.
Efficacy and safety of different systemic drugs in the treatment of uremic pruritus among hemodialysis patients: a network meta-analysis based on randomized clinical trials
Authors: Zhao Xueqian , Sun Haipeng , Li Wei 
Published: April 2024

AimThis network meta-analysis was to analyze and rank the efficacy and safety of different systemic drugs in the treatment of uremic pruritus (UP) among hemodialysis patients.MethodPubMed, Embase, Cochrane Library, and Web of Science databases were searched from inception to 10 July 2023 for randomized controlled trials (RCTs) investigating different drugs in the treatment of UP among hemodialysis patients. Drugs including cromolyn sodium, dexchlorpheniramine, difelikefalin, gabapentin, hydroxyzine, ketotifen, melatonin, montelukast, nalbuphine, nalfurafine, nemolizumab, nicotinamide, pregabalin, sertraline, thalidomide, and placebo were assessed. Outcome measures, including pruritus relief, response, and adverse events, were analyzed. Network plots, forest plots, league tables, and the surface under the cumulative ranking (SUCRA) probabilities were depicted for each outcome.ResultsThe network meta-analysis retrieved 22 RCTs. Gabapentin (69.74%) had the highest likelihood to be the most effective drug for pruritus relief in UP patients receiving hemodialysis, followed by cromolyn sodium and hydroxyzine. Thalidomide (60.69%) and gabapentin (58.99%) were associated with significantly more drug responses for treating UP among patients receiving hemodialysis. Patients who were treated with gabapentin (40.01%) were likely to have risks of adverse events and dizziness. Lower risks of adverse events, nausea, and diarrhea were found in patients who received cromolyn sodium and lower risks of somnolence.ConclusionThis study suggests considering gabapentin treatment when facing a patient suffering from UP. This study provides a reference for the selection of drug therapy for UP patients receiving hemodialysis.
Study on the clinical efficacy and safety of baloxavir marboxil tablets in the treatment of influenza A
Authors: Qiu Chaochao , Cheng Fang , Ye Xinchun , Wu Zhengxing , Ning Hongye , Liu Saiduo , Wu Lianpeng , Zhang Yiyang , Shi Jichan , Jiang Xiangao 
Published: April 2024

ObjectiveTo evaluate the clinical efficacy and safety of baloxavir marboxil tablets in the treatment of influenza A.MethodsAccording to a random sequence generated by computer software, 200 patients with confirmed influenza A were divided into a study group and a control group with 100 cases in each group. Group allocation was concealed using sealed envelopes. The study group was treated with oral administration of baloxavir marboxil tablets, 40 mg once. The control group was given oral oseltamivir capsules, 75 mg twice a day, for five consecutive days. The therapeutic effects, symptom disappearance time and adverse drug reactions of the two groups after 5 days of treatment were compared.ResultsThere was no significant difference in the total effective rate between the two groups (99% vs. 98%, p &gt; 0.05). There was no significant difference in fever subsidence time (1.54 ± 0.66 d vs. 1.67 ± 0.71 d, p &gt; 0.05), cough improvement time (2.26 ± 0.91 d vs. 2.30 ± 0.90 d, p &gt; 0.05) and sore throat improvement time (2.06 ± 0.86 d vs. 2.09 ± 0.83 d, p &gt; 0.05) between the two groups. There was no significant difference in the incidence of adverse drug reactions between the two groups (8% vs. 13%, p &gt; 0.05).ConclusionBaloxavir marboxil tablets can be effectively used in the treatment of patients with influenza A and have a similar efficacy and safety profile as oseltamivir capsules.