bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantification of bioactive constituents of mistletoe leaves (tapinanthus globiferus a. rich) from four different host plants in the EWU community
Authors: A. Owolabi Tunde , O Edobor Salome 
Published: March 2024

Background: Pharmacological activities of the medicinal plant are determined by the chemical substances it contains, these substances are also affected by factors of which geographical and all that surround such plant plays a vital role. Mistletoe is a plant that depends solely on its host. This study evaluated the different phytoconstituents concentrations in Mistletoe (Tapinanthus globiferus) leaves growing on four different host plants (Avocado pear (Persea americana), Orange (Citrus sinensis), Guava (Psidium guajava), and Kolanut (Cola nitida)) in the Ewu community of Edo State, Nigeria.Methods: Qualitative and quantitative phytochemical analyses were carried out using standard methods.Results: The qualitative test revealed the presence of alkaloids, Tannin, Phenolic compounds, Flavonoid, Saponin, while the quantification estimation showed these phytochemicals in varying concentrations. Guava had the highest concentration of Tannin (323.4Â±0.07), Saponin (138.6 Â± 0.02) while Orange has the highest concentration of Flavonoids (632.61 Â± 0.12) followed by Guava (407.88 Â± 0.05), the highest concentration of Phenolics was found in Avocado pear (519.9 Â± 0.29) followed by Guava (273.5 Â± 0.34). The highest Alkaloids were found in Orange (2.20 Â± 0.06) followed by Avocado pear respectively.Conclusion: From this present study, it can be concluded that Mistletoe from different host plants has a different concentration of phytochemicals and is thus expected to have different bioactivities.Â Â
Evolution of the aggressive or scaling character of the water according to the dose of corrosion inhibitor
Authors: Mbayo Kyongo Longo Jerry , Mbuyu Ilunga Eddy , Wa Banza Bonaventure Banza , Kanda Jean-Marie 
Published: March 2024

In the treatment of water to fight against corrosion, there are several techniques that can slow down this phenomenon and thus extend the service life of the pipes. Among these techniques, the use of corrosion inhibitors is one of them. It is in this context that the evolution of the aggressive and turbulent nature of the water of the Lubumbashi River has been studied experimentally through the determination of indicators such as pH, chemical potential, total alkalimetric titre, calcium hardness THCa, free chlorine content, dissolved oxygen content, SO42- sulfate ion content and Ryznard and Langelier index. Numerous relationships between the dose of the inhibitor and the physicochemical parameters of water have been established. Similarly, it has also been shown that the dose variation of the inhibitor is related to the Langelier index and the Ryznard index. Thus, it follows that with the dose of 0.30ml / L, an appreciable decrease in dissolved oxygen, which is the main oxidant in basic medium, is recorded. The use of the inhibitor has a positive effect on corrosion because it acts directly on all physicochemical parameters and on all oxidants. Subject to economic analyzes, the dose of 0.30 ml / L is more advisable especially as it would prevent in the cooling circuit degradation of the thermal coefficient and the formation of precipitates in the exchangers occasioned.Â Â
Antimicrobial activities of Desi Cow Dung Extracts against human pathogens and phytochemical analysis using chloroform extracts
Authors: Nayak Arabinda , Gohel Shivani 
Published: March 2024

The main objective is to examine the anti-microbial properties and Photochemical screening of the cow dung extracts which are useful to kill the pathogens in humans.Nowadays there is increasing microbial drug resistance problem, so new alternative to synthetics drugs are explored. Along with it antimicrobial activities of natural products are in search. Study of anti-microbial activities of desi cow dung extracts of chloroform against microorganisms namely E. coli and K. Pneumonia.Also the phytochemical analysis for the flavonoids, glycosides, steroids, tannins and phenol compounds. The antimicrobial sensitivity test by disk diffusion method and the disk made from the cow dung showed the zone of inhibition in the petri-plates of both the microorganisms namely E. coli and K. Pneumonia.The phytochemical analysis also showed colour change and precipitation except the phenols. As the microorganisms are becoming resistant to the antibiotics and synthetic drugs, new alternate natural drugs can be explored and used against several diseases caused by this microorganisms.Â Â
Apigenin 7-glucoside impedes hypoxia-induced malignant phenotypes of cervical cancer cells in a p16-dependent manner
Authors: Li Yan , Man Xiaoli , Zhang Qing , Wang Xiaowu , Yang Yongli 
Published: March 2024

Abstract
Apigenin 7-glucoside (A7G) can suppress cell proliferation and trigger apoptosis in cervical cancer cells. Considering that hypoxia is associated with the malignant phenotypes in cervical cancer, this study aimed to uncover whether A7G exhibits suppressive effects on the hypoxia-induced malignant phenotype of cervical cancer cells (HeLa cells). Compared to normoxia, hypoxia can enhance the malignant phenotypes of HeLa cells, including cell proliferation, reduced sensitivity against chemotherapeutic agents (oxaliplatin and paclitaxel), cancer stemness, migration, and invasion. A7G intervention (20, 40, and 60 μM) could impair these malignant phenotypes of HeLa cells and upregulate the expression level of total and nuclear p16 proteins. Molecular docking analysis showed the interaction between anion exchanger 1 and A7G. In p16-silencing HeLa cells, the anticancer effects of A7G were absent. Therefore, hypoxia derives malignant phenotypes of HeLa cells, which could be impeded by A7G in a p16-dependent manner.
Assessment of indirect tensile stress and tensile–strength ratio and creep compliance in HMA mixes with micro-silica and PMB
Authors: Al-ghurabi Sahar Basim , Al-gurah Esraa R. , Mohammed Hamza Walaa 
Published: March 2024

Abstract
This study aims to ascertain the effects of polymer-modified bitumen (PMB) and to utilize mineral filler with micro-silica (MS) on various properties of hot-mix asphalt (HMA). In this work, three specimens of an asphalt-concrete mixture were prepared. The first specimen represents a control mixture, the second specimen contains MS at rates 15, 30, and 45% by the total weight of the total aggregate as filler, and the third specimen contains MS and PMB with 4% novolac by the weight of bitumen and 15% hexamine by the weight of the novolac. The properties of designed mixes were evaluated using the indirect tensile strength test, tensile–strength ratio, and creep compliance. The test results showed an increase in the resistance of asphalt concrete to moisture damage, a reduction influence of water on asphalt concrete properties, creep compliance values indicating growing stiffness for asphalt mixture, and enhanced fatigue life. In conclusion, using 45% MS and PMB improved the properties of HMA and provided long-lasting mixtures for highway construction.
Comparative analysis of flow factors and crystallinity in conventional extrusion and gas-assisted extrusion
Authors: Huang Xuemei , Liu Hesheng , Huang Xingyuan , Huang Yibin , Yu Zhong 
Published: March 2024

Abstract
Two-dimensional models of die-melt and die-gas-melt were created using Polyflow software. The radial and axial directions flow rate, shear rate, pressure, and first normal stress of the specimen were numerically simulated under conventional extrusion and gas-assisted extrusion while taking into consideration the heat transfer on the free surface of the specimen. The crystallinity was determined by combining the simulation data with the crystallization kinetics equation. The computation results are then examined using Origin software. The findings demonstrate that the use of gas-assisted extrusion technology can cause the Vx
to decrease or even turn negative by reducing the friction between the melting edge and the die wall. Additionally, it makes Vy
, pressure, shear rate, temperature, first normal stress, and crystallinity increasingly steady and aids in reducing or avoiding the Barus effect. The crystallization phenomena can be measured by using the crystallization kinetics equation. The study of extruded parts at the microscopic level will benefit from this application.
Twist-related parametric optimization of Joule heating-triggered highly stretchable thermochromic wrapped yarns using technique for order preference by similarity to ideal solution
Authors: Wang Yong , Yuan Zihan , Qi Mingkun , Zhang Lizheng , Li Mingwei , Wang Wei , Li Changlong 
Published: March 2024

Abstract
A scalable approach for manufacturing highly stretchable thermochromic wrapped yarns has been reported previously. Herein, the effects of twist-related technological parameters, namely, wrapping density and outer-inner twist ratio are investigated and have been optimized by technique for order preference by similarity to ideal solution (TOPSIS). The results indicate that the preparatory twist-related parameters have a remarkable effect on the spiral geometrical configuration of yarn constituents, and thus in turn influencing the final tensile and elastic properties of wrapped yarns. The wrapping density of 800 T·m−1 and outer-inner twist ratio of 1.25 were considered as the optimal alternative using TOPSIS. Moreover, a negative relation between voltage and color-changing time of yarn spun with optimal parameters was established. It was also found that the color of yarn above elevated triggered voltages always switched from purple to pink but followed different color-changing paths. More importantly, thermochromic response of yarn is insensitive to the applied strain.
Efficacy of etonogestrel subcutaneous implants versus the levonorgestrel-releasing intrauterine system in the conservative treatment of adenomyosis
Authors: Wei Anwen , Tang Xuedong , Yang Wenjuan , Zhou Jianqing , Zhu Weili , Pan Shan 
Published: March 2024

Abstract
To evaluate the clinical efficacy of etonogestrel subcutaneous implant (ENG-SCI) with that of the levonorgestrel-releasing intrauterine system (LNG-IUD) for adenomyosis treatment. A prospective randomized cohort study was conducted including 108 patients (50 patients in ENG-SCI group and 58 in the LNG-IUD group) with adenomyosis from January 2019 to July 2021. After 3 months of treatment, both ENG-SCI group and LNG-IUD group showed significant improvement in patients’ visual analog scale, pictorial blood loss assessment chart (PBAC), and uterine volume (P ＜ 0.05). The uterine volume of patients in LNG-IUD group decreased more significantly than that in the ENG-SCI group since 3 months of treatment. The PBAC score in the LNG-IUD group improved better than that in the ENG-SCI group since 6 months of treatment (P ＜ 0.05). No significant difference in the occurrence rate of ideal vaginal bleeding patterns and the hemoglobin levels between the two groups was observed. The ENG-SCI group had a higher probability of weight gain and progesterone-related side effects (P ＜ 0.05). Both ENG-SCI and LNG-IUD were effective in treatment of adenomyosis. However, LNG-IUD had a more significant effect in treating adenomyosis-related dysmenorrhea, excessive menstrual flow, anemia, and uterine enlargement, with relatively fewer side effects.
Quantitative methods in the analysis of clozapine in human matrices – A scoping review
Authors: Lim Jia Le , Rajagopal Mogana , Akowuah Gabriel Akyirem , Keshavarzi Fazlollah , Alakhali Khaled Mohammed Ahmed 
Published: March 2024

Abstract
Clozapine (CLZ) has retained its clinical utility in the management of schizophrenia despite the discovery of novel antipsychotics, as it possesses unique efficacy in the setting of treatment resistant schizophrenia while causing minimal extrapyramidal symptoms. However, these benefits are offset by the risk of agranulocytosis and other side effects, and therapeutic drug monitoring (TDM) is routinely recommended for patients undergoing treatment with CLZ. A multitude of approaches for the quantification of CLZ have been developed for different settings such as TDM, quality control of pharmaceutical dosage forms, and toxicology studies. Primarily, these approaches fall under one of three branches of analysis, namely, chromatography, electrochemical analysis, and spectrophotometry. This study provides a scoping review of the recent advances in the methods of quantification for CLZ and highlights the potential utility of novel methods in the field of drug quantification.
A feminizmus élménye
Authors: Hegedüs Ferenc 
Published: March 2024

„A »feminizmus élménye« – melynek célzott közönsége a lehető legtöbb individuum – nem politikai álláspont. A patriarchátust könnyebb megfoghatatlan ellenségként kijelölni és monológban felszólalni ellene, mint felhívni a figyelmet egy azzal kéz a kézben járó, szintén hierarchikus gazdasági és társadalmi rendszerre – főként, ha azt a rendszert az adott produktum éppen kiszolgálja.”
Hegedüs Ferenc kritikája a Barbie című filmről.
Upaya Peningkatan Pengetahuan serta Sikap Siswa melalui Pengembangan LKPD PBL Terintegrasi Literasi Lingkungan
Authors: Herawati Meilinda , Nuswowati Murbangun , Susilaningsih Endang , Nurhayati Sri 
Published: March 2024

Pandemi covid-19 telah membawa perubahan terutama dalam segi pendidikan sehingga diperlukan pembelajaran dengan media yang menarik dalam upaya peningkatan pengetahuan peserta didik. Media yang dapat dipakai adalah LKPD. Penelitian kali ini bertujuan mendesain LKPD dengan model pembelajaran berbasis masalah terintegrasi literasi lingkungan untuk meningkatkan pengetahuan pada materi hidrolisis garam. Metode yang dipakai dalam penelitian ini berupa RD dengan model 4D, Define, Design, Development, dan Disseminate. Subjek penelitian merupakan 33 siswa SMA N 3 Salatiga. Instrumen yang digunakan berupa lembar validasi LKPD, soal pretest posttest dengan soal pilihan ganda berjumlah 20 soal, angket respon peserta didik, dan angket sikap. Teknik analisis data yang digunakan terdiri atas analisis kelayakan melalui hasil validasi dan respon kepraktisan, analisis keefektifan produk melalui uji N-gain, ketuntasan hasil belajar, dan ketercapaian sikap, serta keterkaitan antara LKPD dengan pengetahuan dan sikap melalui uji product moment menggunakan SPSS. Berdasarkan hasil penelitian dinyatakan LKPD yang telah didesain memenuhi beberapa kriteria (1) LKPD sangat valid dengan skor dari validator ahli masing-masing 114/116 dan 112/116 dan praktis terlihat melalui hasil angket respon peserta didik sebesar 91%, (2) efektif dalam meningkatkan pengetahuan dengan nilai N-gain 0,62 pada kategori sedang, ketuntasan belajar siswa 100% dan sikap kepedulian peserta didik terhadap lingkungan sebesar 91,35% pada kategori sangat peduli. Keterkaitan LKPD dengan pengetahuan dalam kategori kuat dengan perolehan pearson correlation 0,787, sedangkan keterkaitan LKPD dengan sikap pada kategori lemah dengan perolehan 0,372. Sehingga dapat dikatakan Lembar Kerja Peserta Didik model Problem Based Learning terintegrasi literasi lingkungan layak dan efektif digunakan dalam pembelajarn hidrolisis garam.
The Effectiveness of Socio-scientific Issues-Based Learning and Digital Literacy to Build Critical Thinking Skills for Students of Senior High School
Authors: Izzah Noor , Anggraito Yustinus Ulung , Ridlo Saiful 
Published: March 2024

The graduate’s profile of the middle education unit is expected to be able to achieve national educational goals which consider 21st-century skills such as critical thinking. One of the learning strategies which can build students' critical thinking skills is socio-scientific issues-based learning and digital literacy. This research aims to analyze the effectiveness of socio-scientific issues-based learning and digital literacy to build the critical thinking skills of the students of senior high school. This research is experimental research with a posttest-only control-group design. The samples in this study are the students of class X MIPA 1, X MIPA 2, X MIPA 7, and X MIPA 8, which are taken by random sampling technique. The data taken in this research is the data on critical thinking skills which are collected by test and non-test methods. The results of the research show that (1) based on the t-test, the results of the scores of Sig (2-tailed) < 0.05 mean that the scores of the student's critical thinking skills in the experimental classes are significantly different from the control class. The average scores of the student's critical thinking skills of the experimental classes are higher than the control class scores, so it can be interpreted that the student's critical thinking skills of the experimental classes are better than the control class, (2) the classical completeness in the experimental classes is higher than in the control classes. However, classical completeness in the experimental classes only reaches 65%, (3) the scores of the student response questionnaires in the good-very good category reach 97.2%, with details in the good category (75-84) reaching 59.7%, the very good category (85-100) reaching 37.5%. Thus, it can be concluded that socio-scientific issues-based learning and digital literacy on viruses and bacteria material is effective in building the critical thinking skills of high school students, however, it has not been effective in fulfilling classical completeness.
The Influence of The Environmental Approach on Five-Grade Students’ Critical Thinking Ability
Authors: Afana Reza Maida Nur , Jupriyanto Jupriyanto , Sari Yunita 
Published: March 2024

This study focuses on the influence of learning approaches on students' critical thinking skills, the lack of teacher diversity in teaching, and the utilization of learning media sources. After applying the environmental approach, the purpose was to determine the effect of critical thinking skills and minimum completeness criteria (KKM). The research design is Quasi-Experimental Design (Time Series Design). The research sample was 20 fifth-grade students at SDN Gondo 01. The pretest and posttest normality tests were normally distributed. Output SPSS pretest column sig. has a value of 0.200 > (0.05) means that the data is normally distributed. The posttest results of the SPSS output are in the sig column. The value 0.155 > (0.05) means the data is normally distributed. The paired sample t-test hypothesis test obtained sig. (2-heads) 0.000. If sig. (2-tailed) 0.000 < (0.05), then Ha is accepted, meaning that there is an influence of the environmental approach on students' critical thinking skills. The results of hypothesis testing two t-tests for one Sample obtained the results of Tcount (0.20) and Ttable (2.09). If Tcount > - Ttable, then Ho is accepted, which means that the student has fulfilled the KKM, which is 70.
Key words: Environmental Approach, Critical Thinking, Science Learning.
The Review of Fundamental Framework for Reflective Thinking and Practice in Science Education: Implications for Transformative Science Learning
Authors: Nurhayati Pipih , Widodo Ari , Syamsudin Achmad 
Published: March 2024

The primary objective of this study is to establish a fundamental framework for reflective thinking and practice in science education that can contribute to transformative learning worldwide. The study utilized the SPIDER inclusion criteria to select relevant articles from SCOPUS and WoS databases in March 2023, which included sample, phenomenon of interest, design, evaluation, and research type. The PRISMA framework was also used, which consisted of four steps: identification, screening, eligibility, and inclusion. In the end, the study analyzed 52 articles using Biblioshiny as a tool for analysis. The results indicated that Reflective Practice, International Journal of Science Education, and Education Sciences are the most commonly used sources for research on this topic. Turkey and the USA have shown the highest productivity in terms of research on reflective thinking. The frequency of the term "reflective thinking" has increased steadily over the years, indicating its growing significance in the field of education and research. Several teaching and assesment strategies can play a significant role in facilitating transformative learning by encouraging individuals to solve problems, communicate effectively, exhibit self-confidence, remain engaged, plan and collaborate with others.
Literature and Social Issues: Study of Islam, Secularism, and Humanism in Achdiat’s Atheis Indonesian Novel
Authors: Kamil Sukron 
Published: March 2024

Although religion faces many challenges, such as clashing with modernity and becoming the object of criticism, religion has a thousand lives. One Indonesian novel created by Achdiat Karta Mihardja entitled Atheis (1990) pictured this religious phenomenon. Therefore, this article discusses Islam, secularism, and humanism in the Novel. This is qualitative research with the literary approach that combines the comparative literature theory of American schools and sociology focused on the sociology of modernity and religion. This research finds the novel as a criticism and reconstruction of Islam that is compatible with secularism and humanism in general, though in certain parts they are different. Further, the author of this novel reveals a good and proper Islam based on the text, first, it is concerned not only with the afterlife but also the present and here-ness real life. Thus, he criticizes the Islamic pattern which believes in superstition. Second, the Islamic form according to humanism and moderat feminism as the core of Islam is a public benefit and blessing for the universe. This research concluded that the novel's criticism is in line with the criticism in the scientific sociological Islamic literature.
Неудовлетворённые потребности в медицинской помощи у населения России: результаты Мониторинга общественного здоровья в 2022 г.
Authors: Давитадзе Арсен Паатович , Родионова Татьяна Игоревна , Хабибуллина Алина Ришатовна , Александрова Екатерина Александровна 
Published: March 2024

Под «неудовлетворёнными потребностями в медицинской помощи» понимают ситуации, в которых индивиды осознают потребность в получении медицинских услуг, но в итоге не получают их. Подобные неудовлетворённые потребности (НП) часто встречаются в современных системах здравоохранения и с разной частотой возникают у разных групп населения. Данное исследование впервые изучает проблему НП в медицинской помощи на российских данных, рассматривая их распространённость среди разных групп населения с помощью поведенческой модели Андерсена и учитывая различные барьеры для получения медицинской помощи. Данные «Национального мониторинга общественного здоровья» показали, что каждый второй россиянин (52,4%) сталкивался с неудовлетворёнными потребностями в медицинской помощи в 2022 г. Чаще такие НП возникали у женщин, молодых, имеющих проблемы со здоровьем и людей с высшим образованием. В отличие от других стран, для России различия в распространённости НП у групп индивидов с разными социально-экономическими статусами не обнаружены. Респонденты связывали свои НП преимущественно с барьером принятия медицинской помощи (37%), т. е. с их отношением к своему здоровью и системе здравоохранения, а также личными ситуациями, которые препятствовали обращениям за помощью. В полтора раза реже встречались НП в связи с барьером удобства получения помощи (23,4%), а в два раза реже – в связи с барьером недостаточной доступности медицинской помощи (19,4%). Трансформация отношения россиян к собственному здоровью, помимо развития доступности и удобства получения медицинской помощи, может способствовать снижению распространённости НП.