bluuebunny/crossref_metadata_2025_split huggingface dataset:
Syntheses of Ulocladol.
Authors: Abe Hitoshi , Fukumoto Tomoko , Nishioka Keisuke , Arai Masatsugu , Takeuchi Yasuo , Harayama Takashi 
Published: April 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of New Pyrrolidine Derivatives as Inhibitors of α‐Mannosidase and of the Growth of Human Glioblastoma Cells.
Authors: Favre Sylvain , Fiaux Helene , Schuetz Catherine , Vogel Pierre , Juillerat‐Jeanneret Lucienne , Gerber‐Lemaire Sandrine 
Published: April 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Influence of External Factors on Amorphous and Nanocrystalline Soft Magnetic Alloys Studied by Mossbauer Spectroscopy
Authors: Degmova J. , Sitek J. , Bednarcik J. 
Published: April 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Phase Relations in Alkaline Earth—Manganese—Oxygen Systems: Equilibrium and Metastable States
Authors: Balakirev V. F. , Golikov Yu. V. 
Published: April 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Inorganic Nanofluorides and Related Nanocomposites
Authors: Kuznetsov S. V. , Osiko V. V. , Tkatchenko E. A. , Fedorov P. P. 
Published: April 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
The Kinetic Ordering and Growth Dissymmetrisation in Crystalline Solid Solutions
Authors: Shtukenberg A. G. , Punin Yu. O. , Frank‐Kamenetskaya O. V. 
Published: April 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Nitrilase and Its Application as a ′Green′ Catalyst
Authors: Singh Ram , Sharma Rakesh , Tewari Neetu , Geetanjali Geetanjali , Rawat Diwan S. 
Published: April 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Chemistry and Biology of a Series of Antitumor Sulfonamides: Exploiting Transcriptomic and Quantitative Proteomic Analyses for Exploring Druggable Chemical Space
Authors: Owa Takashi 
Published: April 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthetic Ion Channels and Pores (2004—2005)
Authors: Sisson Adam L. , Shah Muhammad Raza , Bhosale Sheshanath , Matile Stefan 
Published: April 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Three‐Dimensional Hydrocarbon Cores Based on Multiply Fused Cyclopentane and Indan Units: Centropolyindans
Authors: Kuck Dietmar 
Published: April 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Three‐Membered‐Ring‐Based Molecular Architectures
Authors: de Meijere Armin , Kozhushkov Sergei I. , Schill Heiko 
Published: April 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Chemistry of the Carba‐closo‐dodecaborate(‐) Anion, CB11H‐12.
Authors: Koerbe Stefanie , Schreiber Peter J. , Michl Josef 
Published: April 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
From Macrocyclic Oligo‐acetylenes to Aromatic Ring Carbo‐mers
Authors: Maraval Valerie , Chauvin Remi 
Published: April 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Two Galactosyltransferases′ Selection of Different Binders from the Same Uridine‐Based Dynamic Combinatorial Library
Authors: Valade Anne , Urban Dominique , Beau Jean‐Marie 
Published: April 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Chemical Constituents of the Plants from the Genus Laggera
Authors: Li Xing‐Cui , Huo Chang‐Hong , Shi Qing‐Wen , Kiyota Hiromasa 
Published: April 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
High prevalence of p53 exon 4 mutations in soft tissue sarcoma
Authors: Das Parimal , Kotilingam Dhanasekaran , Korchin Borys , Liu Jeuhui , Yu Dihua , Lazar Alexander J. , Pollock Raphael E. , Lev Dina 
Published: April 2007

AbstractBACKGROUNDp53 is the most commonly mutated gene in cancer, including soft tissue sarcoma (STS). The authors characterized p53 alterations (protein accumulation and gene mutation) in STS to evaluate possible associations with patient outcomes.METHODSThirty‐one STS specimens (multiple histologies) were analyzed by p53 immunohistochemistry (IHC) and direct DNA sequencing of p53 exons 2–11 and then correlated with outcomes.RESULTSDirect p53 sequencing detected mutations in 10 of 31 STSs; 7 of 10 were missense mutations, whereas 3 of 10 were either insertions or frameshift mutations, leading to nonfunctional truncated p53; 7 of these p53 mutations have not been previously described. Four p53 exon 4 mutations were identified, a p53 region previously unknown to be mutation prone. Eighteen of the 31 specimens expressed p53 when the authors used the clinical IHC assay of their institution. Interassay concordance of 48% was observed; only 6 of 10 sequencing‐identified p53 mutated specimens exhibited nuclear p53 protein expression by IHC, whereas 12 of 18 specimens exhibiting p53 protein expression by IHC harbored sequencing‐identified wild‐type p53. Decreased survival was observed in STS patients bearing sequencing‐identified mutated p53 versus wild‐type p53, as was a correlation between IHC‐determined nuclear p53 protein expression and decreased survival.CONCLUSIONSp53 protein stabilization and p53 mutation frequently occur in STS, and both suggest worse outcomes for patients so affected. However, increased p53 protein expression does not necessarily indicate p53 gene mutation. The high incidence of exon 4 mutations found in STS suggests that p53 sequencing should not be limited to the core DNA binding domain. Cancer 2007. © 2007 American Cancer Society.
Loss of heterozygosity and human telomerase reverse transcriptase (hTERT) expression in bronchial mucosa of heavy smokers
Authors: Capkova Linda , Kalinova Marketa , Krskova Lenka , Kodetova Daniela , Petrik Frantisek , Trefny Martin , Musil Jaromir , Kodet Roman 
Published: April 2007

AbstractBACKGROUNDLung carcinogenesis is a multistep process of accumulation of genetic changes, including loss of heterozygosity (LOH), and precedes phenotypic transformation of the bronchial mucosa. The activity of telomerase, correlating with the hTERT mRNA expression, is detectable in a majority of neoplasms. In this study, the frequency of LOH and hTERT expression in bronchial mucosa of heavy smokers in bronchoscopic biopsies was analyzed.METHODSLOH was examined in 122 bronchial specimens from 81 smokers (67 normal mucosa/bronchitis, 12 squamous metaplasia, 28 dysplasia, 15 bronchogenic carcinoma specimens) by polymerase chain reaction (PCR) and capillary electrophoresis by using 7 fluorescence‐labeled markers matching 5 chromosomal regions. hTERT expression was analyzed in 87 specimens (45 normal mucosa/bronchitis, 12 squamous metaplasia, 18 dysplasia, 12 bronchogenic carcinoma specimens) by real‐time quantitative reverse‐transcription PCR.RESULTSLOH was detected in at least 1 chromosomal region in 51 of 122 (41.8%) specimens; the incidence in normal bronchial mucosa and preneoplastic lesions was similar (20%–40%); a substantial rise (87%) occurred in carcinomas. The median normalized hTERTN values were 6.67 in normal epithelium/chronic bronchitis, 18.38 in squamous metaplasia, 13.31 in epithelial dysplasia, and 75.46 in carcinomas. These results were significantly different (P = .0036). With an increasing number of LOH, the median value of hTERTN expression rose, but hTERT was expressed also in tissue samples without any LOH detection.CONCLUSIONSResults indicated that hTERT expression, together with LOH, represent early events in lung carcinogenesis, as both were detected in precancerous lesions and in normal epithelium of heavy smokers. Cancer 2007. © 2007 American Cancer Society.
Theoretical Prediction and the First IR Matrix Observation of Several L‐Cysteine Molecule Conformers
Authors: Dobrowolski Jan Cz. , Jamróz Michał H. , Kołos Robert , Rode Joanna E. , Sadlej Joanna 
Published: April 2007

AbstractFor the first time the argon‐matrix low‐temperature IR spectra of cysteine are recorded. They reveal a quite complicated spectral pattern, which can also be reproduced in the N2 matrix. Assignment of the observed spectra is undertaken on the basis of comparison of the experimental and calculated B3LYP/aug‐cc‐pVDZ anharmonic IR spectra. The presence of at least three, and possibly even six or more, cysteine conformers with and without intramolecular hydrogen bonding is confirmed. On the basis of the calculated vibrational circular dichroism spectra, we predict this technique to be more distinctive for conformers than IR absorption is.
ZnO: Material, Physics and Applications
Authors: Klingshirn C. 
Published: April 2007

AbstractZnO is presently experiencing a research boom with more than 2000 ZnO‐related publications in 2005. This phenomenon is triggered, for example, by hope to use ZnO as a material for blue/UV optoelectronics as an alternative to GaN, as a cheap, transparent, conducting oxide, as a material for electronic circuits that are transparent in the visible or for semiconductor spintronics. Currently, however, the main problem is to achieve high, reproducible and stable p‐doping. Herein, we critically review aspects of the material growth, fundamental properties of ZnO and ZnO‐based nanostructures and doping as well as present and future applications with emphasis on the electronic and optical properties including stimulated emission.
T lymphocyte rolling and recruitment into peripheral lymph nodes is regulated by a saturable density of L‐selectin (CD62L)
Authors: Galkina Elena , Florey Oliver , Zarbock Alexander , Smith Bryan R. E. , Preece Graham , Lawrence Michael B. , Haskard Dorian O. , Ager Ann 
Published: April 2007

AbstractL‐selectin mediates tethering and rolling of lymphocytes in high endothelial venules (HEV) of lymph nodes (LN) and of leukocytes at inflammatory sites. We used transgenic mice expressing varying levels of wild‐type or a non‐cleavable mutant form of L‐selectin on T cells to determine the relationship between L‐selectin density, tethering and rolling, and migration into LN. T cells expressing supraphysiological levels of either wild‐type or non‐cleavable L‐selectin showed rolling parameters similar to C57BL/6 T cells in hydrodynamic flow assays and during rolling in Peyer's patch HEV. In contrast, PMA‐ or antigen‐activated T cells and L‐selectin+/– T cells expressing subphysiological levels of L‐selectin showed reduced numbers of rolling cells with increased rolling velocity. Short‐term homing studies showed that elevated expression of L‐selectin above physiological levels had no effect on T cell migration to LN; however, low L‐selectin expression resulted in reduced T cell homing to LN. Thus, T lymphocyte migration into LN is regulated by the density of cell surface L‐selectin. In addition, there is a saturable density of L‐selectin required for optimal homing to PLN in C57BL/6 mice, the L‐selectin level on circulating naive T cells promotes optimal homing, and increased expression above saturating levels promotes no further increase in T cell recruitment.
Transforming growth factor β1 up‐regulates interferon regulatory factor 8 during dendritic cell development
Authors: Ju Xin‐Sheng , Ruau David , Jäntti Piritta , Seré Kristin , Becker Christiane , Wiercinska Eliza , Bartz Clemens , Erdmann Bettina , Dooley Steven , Zenke Martin 
Published: April 2007

AbstractLangerhans cells (LC) represent the cutaneous contingent of dendritic cells (DC). Their development critically depends on transforming growth factor β1 (TGF‐β1) as demonstrated by analysis of TGF‐β1–/– mice, which lack LC. Here we used a two‐step culture system and transcriptional profiling by DNA microarrays to search for TGF‐β1 target genes in DC. The study identified interferon regulatory factor 8 (IRF‐8) as a novel target gene of TGF‐β1 signaling in DC. TGF‐β1 effectively induced Smad2/3 phosphorylation and IRF‐8 RNA and protein expression. Blocking the TGF‐β1/Smad pathway by ectopic expression of inhibitory Smad7 and by SB431542 inhibitor abolished TGF‐β1 induced up‐regulation of IRF‐8. Furthermore, TGF‐β1‐dependent induction of IRF‐8 occurred in the absence of protein biosynthesis, suggesting a direct action of TGF‐β1/Smad signaling on IRF‐8 gene activity. TGF‐β1 also induced expression of the chemokine receptor CCR7 and enhanced DC migration towards CCR7 ligand ELC. DC of IRF‐8–/– mice show reduced CCR7 expression and migratory activity, thereby implicating the TGF‐β1/Smad/IRF‐8 signaling pathway in CCR7 regulation. Thus, this study identified a novel TGF‐β1/Smad/IRF‐8 signaling pathway with an impact on DC phenotype and function.
CD59a deficiency exacerbates influenza‐induced lung inflammation through complement‐dependent and ‐independent mechanisms
Authors: Longhi M. Paula , Williams Anwen , Wise Matthew , Morgan B. Paul , Gallimore Awen 
Published: April 2007

AbstractInfluenza‐specific immune activity not only promotes virus clearance but also causes immunopathology, thereby underlining the importance of mounting a measured anti‐viral immune response. Since complement bridges both the innate and adaptive immune systems and has been implicated in defence against influenza, the role of the complement regulator CD59a in modulating the response to influenza was explored. For this purpose, immune responses to influenza virus, strain E61‐13‐H17, in mice deficient in the complement regulator protein CD59a (Cd59a–/– mice) were compared to those in wild‐type mice. The severity of lung inflammation was significantly enhanced in the lungs of Cd59a–/– mice with increased numbers of infiltrating neutrophils and CD4+ T cells. When complement was inhibited using soluble complement receptor 1, the frequency of lung‐infiltrating neutrophils in influenza‐infected Cd59a–/– mice was much reduced whilst numbers of CD4+ T cells remained unchanged. These results demonstrate that CD59a, previously defined as a complement regulator, modulates both the innate and adaptive immune response to influenza virus by both complement‐dependent and ‐independent mechanisms.
An Inorganic Aggregate Based on a Sandwich‐Type Polyoxometalate with Lanthanide and Potassium Cations: From 1D Chiral Ladder‐Like Chains to a 3D Open Framework
Authors: Chen Weilin , Li Yangguang , Wang Yonghui , Wang Enbo 
Published: April 2007

AbstractThe reaction of sandwich‐type polyanion [Mn4Si2W18O68(H2O)2]12–, ceric sulfate, and potassium citrate in an acidic aqueous solution led to the isolation of a new compound K4Na2[{Ce(H2O)7}2Mn4Si2W18O68(H2O)2]·21.5H2O (1), which crystallizes in the space group P212121 with a = 12.040(2) Å, b = 26.094(5) Å, c = 30.043(6) Å, V = 9439(3) Å3, Z = 4, and flack parameter x = 0.63(1). X‐ray diffraction analysis reveals that 1 consists of novel chiral ladder‐like chains based on sandwich‐type polyanions and lanthanide cations, which are further connected into a three‐dimensional open framework by potassium cations.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
Who or what are you?: Facial orientation and person construal
Authors: Cloutier Jasmin , Macrae C. Neil 
Published: April 2007

AbstractAn extensive literature has documented the cognitive benefits that accrue from a categorical conception of others. While informative, this work has overlooked the fact that, prior to the application of categorical thinking as an economizing cognitive tool, perceivers must first extract category‐triggering information from available facial cues. What this suggests is that an impetus to construe others categorically may reside in the perceptual operations that guide the preliminary stages of person understanding. This possibility was explored in three experiments that investigated the effects of stimulus rotation on the efficiency of identity‐based and category‐based construal. In the first experiment, sex categorization was compared directly to identity‐based construal. Subsequent experiments then investigated the efficiency of sex (Experiment 2) and race (Experiment 3) categorization when critical category‐specifying facial cues were present and absent. The results demonstrated that categorical responding is driven by the extraction of featural information from faces, a finding that informs recent theoretical accounts of person perception. Copyright © 2007 John Wiley & Sons, Ltd.
Integrated 2‐D CE
Authors: Santos Bricio , Simonet Bartolomé M. , Ríos Ángel , Valcárcel Miguel 
Published: April 2007

AbstractA simple methodology for converting a commercial CE‐MS instrument into an integrated 2‐D CE system has been developed. The first‐dimensional capillary operates as a typical CE instrument with UV/visible detection. Fractions leaving the first dimension are automatically collected and introduced into the second dimension, performed on a CE‐MS apparatus, for analysis. The integrated system allows fractions in the second dimension to be analyzed using various electrophoretic modes. As an example, in this work we performed the separation of two families of antibiotics (nitroimidazoles and tetracyclines) in the first dimension and the subsequent resolution of the antibiotics in each family (nitroimidazoles were resolved by MEKC and tetracyclines by CZE) in the second dimension. The proposed system, which operates in an highly automatic manner, is flexible and allows various combination of electrophoretic modes to be implemented. In addition, the use of a mass spectrometer detector in the second dimension further increases the analytical potential of the system as a result of the high selectivity and wealth of structural information provided by the MS detector.
NACE‐ESI‐MS combined with on‐line concentration for high‐sensitivity analysis of quinolizidine alkaloids
Authors: Wang Shufang , Qu Haibin , Cheng Yiyu 
Published: April 2007

AbstractA rapid, reproducible and high‐sensitivity NACE‐ESI‐MS method was developed for the analysis of sophoridine, matrine, sophocarpine and oxymatrine in the roots of Sophora flavescens Ait. and S. tonkinensis Gagnep. Field‐amplified sample stacking with electromigration‐injection (FASS‐EMI) was first used in NACE for the on‐line concentration of the alkaloids. The conditions of NACE separation, FASS‐EMI stacking and MS detection were systematically optimized. The optimum NACE buffer was an electrolyte containing 50 mM ammonium acetate, 0.5% acetic acid and 30% ACN in methanol. The sensitivity was improved by about 100‐fold by the FASS‐EMI technique, which was further improved by more than 1000‐fold with MS detection. The RSDs (n = 6) of the relative migration time and relative peak area of each peak were less than 0.3 and 2.4% for intra‐day and less than 5.1 and 6.0% for inter‐day, respectively. The LODs (S/N = 3) of analytes were determined to be 0.0210–0.0446 ng/mL. A bioanalytical method based on this NACE‐ESI‐MS method may be developed for the analysis of the alkaloids in biological sample matrices (plasma, urine, etc.) after effective ion removal.
Dielectrophoretic manipulation of fluorescing single‐walled carbon nanotubes
Authors: Mureau Natacha , Mendoza Ernest , Silva S. Ravi P. 
Published: April 2007

AbstractWe investigate the behavior of fluorescing single‐walled carbon nanotubes (SWCNTs) under dielectrophoretic conditions and demonstrate their collection with fluorescence microscopy. SWCNTs are dispersed in water with the aid of a nonionic surfactant, Triton ­X‐­100, and labeled through noncovalent binding with the dye 3,3′‐dihexyloxacarbocyanine iodide (diOC6). The chromophore's affinity to the SWCNTs is due to π‐stacking interactions. Carbon nanotube (CNT) localization is clearly identified on the fluorescence images, showing that the nanotubes concentrate between the electrodes and align along the electric field lines.
SDS disc electrophoresis of proteins in homogeneous, low‐concentrated polyacrylamide gels
Authors: Maly I. Piotr , Nitsch Cordula 
Published: April 2007

AbstractIn the attempt to separate in a single gel run low‐ and high‐molecular‐weight proteins, we present here a multiphasic buffer system designed for this purpose. It avoids the continuous stacking of SDS as it occurs in the ’︁classical' SDS‐PAGE. The system allows complete stacking and destacking of proteins in the 3.5–250 kDa range at acrylamide concentrations as low as 4.5% T (total acrylamide concentration in %) and 2.6% C (degree of cross‐linking in %). Taurine is used as the trailing ion in the cathode buffer and in the resolving zone of the gel, and two different counterions (Tris and imidazole) in the stacking zone. The gel system is easy to prepare and, due to the very low acrylamide concentrations, it is ideal for analytical as well as for preparative tasks.