bluuebunny/crossref_metadata_2025_split huggingface dataset:
Breast cancer statistics for Japan in 2022: annual report of the national clinical database-breast cancer registry—clinical implications including chemosensitivity of breast cancer with low estrogen receptor expression
Authors: Nagahashi Masayuki , Kumamaru Hiraku , Kinukawa Naoko , Iwamoto Takayuki , Kawashima Masahiro , Kinoshita Takayuki , Konishi Takaaki , Sagara Yasuaki , Sasada Shinsuke , Saji Shigehira , Sanuki Naoko , Tanakura Kenta , Niikura Naoki , Miyashita Minoru , Yoshida Masayuki , Ishida Takanori , Taira Naruto 
Published: February 2025

Abstract
This is an annual report by the Japanese Breast Cancer Society, which provides statistics on the clinical data on breast cancer in Japan, extracted from the National Clinical Database-Breast Cancer Registry (NCD-BCR). This report includes an update of 102,453 breast cancer cases at 1339 institutions registered in the NCD-BCR in 2022. Among the 101,793 female patients, the median age at cancer diagnosis was 62 years (interquartile range, 50–73 years), and 29.4% of the patients were premenopausal. Of these patients, 15,437 (15.2%) and 42,936 (42.2%) were diagnosed with stage 0 and I disease, respectively. Estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) were positive in 78.7%, 69.4%, and 12.8% of the patients, respectively. Of the 97,154 patients without distant metastasis, 40,521 (41.7%) underwent breast-conserving surgery, and 5780 (5.9%) patients underwent some form of breast reconstruction procedures at the time of mastectomy. A total of 66,894 (68.9%) patients were treated with sentinel lymph node biopsy and 7155 (7.4%) patients were treated with sentinel lymph node biopsy followed by axillary node dissection. In the group of patients treated with breast-conserving surgery (n = 40,521), 29,500 (72.8%) received whole-breast irradiation. In the group of patients who underwent mastectomy (n = 54,476), 6226 (11.4%) received radiation therapy to the chest wall. Of the 13,950 patients receiving preoperative chemotherapy with or without molecular targeted therapy, 4308 (30.9%) achieved a pathological complete response, with the highest rate of 60.5% in patients with the hormone receptor-negative/HER2-positive subtype.
A reusable public transport electronic ticket system with fast validation
Authors: Borges Ricard , Sebé Francesc 
Published: February 2025

Abstract
This paper presents an electronic ticket system for public transport which provides reusability in the sense that, after the validation of a ticket, a traveler is enabled to perform a journey which can include a limited number of transfers before an expiration time. The proposal has been designed following a privacy-by-design approach. Travelers are only required to identify themselves if requested to prove possession of a valid ticket by an officer. Otherwise, they can travel without being required to disclose their identity (anonymity). Also, the diverse interactions of a traveler with the system cannot be related to them (unlinkability). The security and privacy requirements are achieved by making use of advanced cryptographic techniques. The system has been simulated and proven to provide running times which make it appropriate for a real deployment. When compared to an existing proposal designed for an equivalent scenario, the reduction in the time required for ticket validation is especially remarkable. In effect, all the use cases with real-time constraints (“Ticket validation”, “Get-in”, and “Get-out”) can be run in less than one second.
A Scoping Review of Preclinical Environmental Enrichment Protocols in Models of Poststroke to Set the Foundations for Translating the Paradigm to Clinical Settings
Authors: Oppici Luca , Bērziņa Guna , Hestetun-Mandrup Ann Marie , Løvstad Marianne , Opheim Arve , Pacheco Matheus M. , Rafsten Lena , Sunnerhagen Katharina S. ,   PEER-HOMEcare consortium, Rudd James R. 
Published: February 2025

Abstract
The translation of the highly effective Environmental Enrichment (EE) paradigm from preclinical animal models to human clinical settings has been slow and showed inconsistent results. The primary translational challenge lies in defining what constitutes an EE for humans. To tackle this challenge, this study conducted a scoping review of preclinical EE protocols to explore what constitutes EE for animal models of stroke, laying the foundation for the translation of EE to human application. A systematic search was conducted in the MEDLINE, PsycINFO, and Web of Science databases to identify studies that conducted an EE intervention in the post-stroke animal model. A total of 116 studies were included in the review. A critical reflection of the characteristics of the included studies revealed that EE for post-stroke is a strategy that frequently modifies the animals’ daily environment to create a richness of spatial, structural, and/or social opportunities to engage in a variety of daily life-related motor, cognitive, and social exploratory activities. These activities are relevant to the inhabiting individual and involve the activation of the body function(s) affected by the stroke. This review also identified six principles that underpinned the EE protocols: complexity (spatial and social), variety, novelty, targeting needs, scaffolding, and integration of rehabilitation tasks. These findings can be used as steppingstones to define what constitutes EE in human clinical applications and to develop a set of principles that can inform the design of EE protocols for patients after a stroke.
Effects of 12-month physical and cognitive training on sarcopenia determinants in older adults: a subgroup analysis of a randomised clinical trial
Authors: Hämäläinen Onni Oskari , Savikangas Tiina Marketta , Tirkkonen Anna-Katriina , Alén Markku Juhani , Hautala Arto Jorma , Sipilä Sarianna 
Published: February 2025

Abstract

Background
Low physical activity is a major risk for sarcopenia. Whether training according to physical activity guidelines accompanied with cognitive training is effective on sarcopenia, remains unclear.

Aims
We investigated whether the effects of 12-month physical and cognitive training (PTCT) and physical training (PT) on grip and knee extension strength, muscle mass, and walking speed differed between older adults with and without sarcopenia.

Methods
Community-dwelling older adults (N = 314, mean age 74.5 ± 3.8 years, 60% women) who did not meet physical activity guidelines were randomized to PTCT and PT groups. PT for both groups included supervised and home-based multicomponent physical training. Cognitive training (CT) included computer-based exercises for executive functioning. Sarcopenia was determined according to the European Working Group on Sarcopenia in Older People 2019 criteria. Generalized estimation equation analysis were conducted.

Results
Compared to PT, PTCT had no additive effect on strength, muscle mass, or walking speed in participants with or without sarcopenia. In pooled data (PT + PTCT) change in the grip strength was greater in sarcopenia (n = 49) group compared to non-sarcopenia (n = 264) group (interaction, p =.014). Both groups improved knee extension strength, and walking speed, but no statistically significant difference between the groups were observed. Muscle mass did not change in either group.

Conclusion
Physical training according to physical activity recommendations improves muscle strength, walking speed, and maintains muscle mass in sarcopenia. Additional cognitive training had no benefits on these outcomes.

Trial registration number
ISRCTN52388040 and date of registration 20/1/2017.
ACQUIRED: An Innovative Asynchronous Modality to Increase Quality Teacher-Learner Dialogue and Overcome Classroom Barriers in Basic Science Medical Education
Authors: Lewis Brianne E. , Attardi Stefanie M. , Sawarynski Kara E. 
Published: February 2025

Abstract
Learners are faced with psychological and temporal classroom barriers that may preclude participation and learning. We present an asynchronous instructional design modality aiming to address learning barriers, retain active learning, and foster quality teacher-learner interactions. We designed and evaluated individualized online lessons constructed with flexible navigation, short instructional videos, integrated formative assessment, and reflection questions with bidirectional teacher-learner communication. Narrative student comments (n = 3075, from 33 basic science sessions over three cohorts of 125 students) were extracted from faculty evaluations, and descriptive coding identified strengths and constructive criticisms. Data are presented as mean ± SD. A majority of comments were positive (76.6% ± 2.12%) with 43.5% ± 8.7% of these focused on the ACQUIRED modality. Within these responses, students most benefited from formative practice questions (18.6% ± 2.3%), the modular format (17.3% ± 2.7%), engagement with material (11.1% ± 0.9%), ease of asking questions (9.2% ± 2.4%), overall organization (8.0 ± 2.8%), and fast responsiveness from the teacher (7% ± 2.0). Fewer comments were constructive (15.0 ± 2.1%), with 51.5% ± 30.9% of these focused on the ACQUIRED modality. More formative questions (30.5% ± 21.8%) were described for improvement. Our data informed the design of the ACQUIRED model for asynchronous instruction, emphasizing ACcessible QUality Interactions and REsponsive Design. The model addresses learning and participation barriers and fosters meaningful, bidirectional teacher-learner interactions.
Multifunctional Janus-Structured Polytetrafluoroethylene-Carbon Nanotube-Fe3O4/MXene Membranes for Enhanced EMI Shielding and Thermal Management
Authors: Shao Runze , Wang Guilong , Chai Jialong , Lin Jun , Zhao Guoqun , Zeng Zhihui , Wang Guizhen 
Published: February 2025

Abstract
Herein, a novel Janus-structured multifunctional membrane with integrated electromagnetic interference (EMI) shielding and personalized thermal management is fabricated using shear-induced in situ fibrillation and vacuum-assisted filtration. Interestingly, within the polytetrafluoroethylene (PTFE)-carbon nanotube (CNT)-Fe3O4 layer (FCFe), CNT nanofibers interweave with PTFE fibers to form a stable “silk-like” structure that effectively captures Fe3O4 particles. By incorporating a highly conductive MXene layer, the FCFe/MXene (FCFe/M) membrane exhibits excellent electrical/thermal conductivity, mechanical properties, and flame retardancy. Impressively, benefiting from the rational regulation of component proportions and the design of a Janus structure, the FCFe/M membrane with a thickness of only 84.9 µm delivers outstanding EMI shielding effectiveness of 44.56 dB in the X-band, with a normalized specific SE reaching 10,421.3 dB cm2 g−1, which is attributed to the “absorption-reflection-reabsorption” mechanism. Furthermore, the membrane demonstrates low-voltage-driven Joule heating and fast-response photothermal performance. Under the stimulation of a 3 V voltage and an optical power density of 320 mW cm−2, the surface temperatures of the FCFe/M membranes can reach up to 140.4 and 145.7 °C, respectively. In brief, the FCFe/M membrane with anti-electromagnetic radiation and temperature regulation is an attractive candidate for the next generation of wearable electronics, EMI compatibility, visual heating, thermotherapy, and military and aerospace applications.
Review: Advanced Drive Technologies for Bionic Soft Robots
Authors: Deng Chengyao , Li Zhenkun 
Published: February 2025

Abstract
This article provides a comprehensive exploration of the current research landscape in the field of soft actuation technology applied to bio-inspired soft robots. In sharp contrast to their conventional rigid counterparts, bio-inspired soft robots are primarily constructed from flexible materials, conferring upon them remarkable adaptability and flexibility to execute a multitude of tasks in complex environments. However, the classification of their driving technology poses a significant challenge owing to the diverse array of employed driving mechanisms and materials. Here, we classify several common soft actuation methods from the perspectives of the sources of motion in bio-inspired soft robots and their bio-inspired objects, effectively filling the classification system of soft robots, especially bio-inspired soft robots. Then, we summarize the driving principles and structures of various common driving methods from the perspective of bionics, and discuss the latest developments in the field of soft robot actuation from the perspective of driving modalities and methodologies. We then discuss the application directions of bio-inspired soft robots and the latest developments in each direction. Finally, after an in-depth review of various soft bio-inspired robot driving technologies in recent years, we summarize the issues and challenges encountered in the advancement of soft robot actuation technology.
Internal Capillary-Gravity Wilton Ripples
Authors: Akers Benjamin F. , Ambrose David M. 
Published: February 2025

Abstract
Periodic traveling waves at the interface of two incompressible, inviscid fluids subject to gravity and surface tension are studied. We focus on the case in which the linearization about the quiescent state has a two-dimensional kernel. We prove the existence of sheets of traveling waves in this circumstance. We also compute Wilton ripples in which the leading term has a (1:2) harmonic resonance, the triad ripple configuration. Global branches of waves are computed, terminating in three types of self-intersecting waves.
How Can We Improve the Government’s Research and Technology for Disasters and Safety?
Authors: Yum Seungil 
Published: February 2025

Abstract

Objective
This study explores how we can improve the government’s research and technology for disasters and safety.

Methods
This study employs the Structural Equation Model (SEM) based on 268 experts’ perspectives.

Results
R&D performance exerts a directly significant impact on R&D achievement with the coefficient of 0.429. Second, while professionality and environment of R&D do not show a direct effect on achievement, they exhibit an indirect effect on it with the coefficient of 1.124 and 0.354, respectively. Third, R&D professionality exerts a significant impact on the R&D environment (0.964), and R&D environment has a positive effect on R&D performance (0.827).

Conclusion
Governments and policymakers should develop disaster and safety policies by understanding direct and indirect effects and the relationship of factors related to R&D for improving R&D achievement.
Investigation of Avalanche Events Occurring in Palandöken Ski Resort
Authors: Torpuş Kemal , Usta Galip , Atalay Ezgi , Gündüz Fatma 
Published: February 2025

Abstract
The aim of the study is to examine the avalanche events that occurred in Erzurum Palandöken Ski Resort. Palandöken’s topography makes it vulnerable to avalanches. Avalanches are the rapid and sudden flow of snow masses accumulated on slopes and are considered one of the natural disasters. Several avalanches have occurred on Palandöken Mountain, leading to tragic results. In 1974, six people were buried under an avalanche and rescue teams were injured in a secondary avalanche. In subsequent years, avalanches died four people in 1975, one person in 1976, and eight people on Dragon Peak in 1977. In 2006, one tourist died in an avalanche on Palandöken Mountain. The last avalanche disaster on Palandöken Mountain, which occurred on December 21, 2024, resulted in the death of an athlete from the Kocaeli Judo National Team of the Turkish Olympic Preparation Center. Palandöken, one of Türkiye’s leading winter tourism destinations, hosts international events but faces significant avalanche risks due to its topography. In order to reduce these risks, it is essential to establish avalanche early warning and monitoring systems, provide avalanche safety training for tourists and personnel, and implement infrastructure measures to reduce avalanche hazards.
Review of microRNA detection workflows from liquid biopsy for disease diagnostics
Authors: Naranbat Dulguunnaran , Herdes Emilia , Tapinos Nikos , Tripathi Anubhav 
Published: February 2025

Abstract
MicroRNAs have emerged as effective biomarkers in disease diagnostics, particularly cancer, due to their role as regulatory sequences. More recently, microRNAs have been detected in liquid biopsies, which hold immense potential for early disease diagnostics. This review comprehensively analyses distinct liquid biopsy microRNA detection methods validated with clinical samples. Each step in the microRNA detection workflow, including sample collection, RNA isolation, processing, and detection of target microRNAs, has been thoroughly assessed. The review discusses the advantages and limitations of established and novel techniques in microRNA detection workflows, discussing their diagnostic capabilities and potential for future implementation at scale.
Spectral Polyhedra
Authors: Sanyal Raman , Saunderson James 
Published: February 2025

AbstractA spectral convex set is a collection of symmetric matrices whose range of eigenvalues forms a symmetric convex set. Spectral convex sets generalize the Schur-Horn orbitopes studied by Sanyal–Sottile–Sturmfels (2011). We study this class of convex bodies, which is closed under intersections, polarity and Minkowski sums. We describe orbits of faces and give a formula for their Steiner polynomials. We then focus on spectral polyhedra. We prove that spectral polyhedra are spectrahedra and give small representations as spectrahedral shadows. We close with observations and questions regarding hyperbolicity cones, polar convex bodies and spectral zonotopes.
Overcoming ideology-consistent biases: does it help to make things easier?
Authors: Gustafsson Philip U. , Lindholm Torun , Isohanni Freja , Svenson Ola , Appelbom Sophia 
Published: February 2025

Abstract
In 2 experiments, we attempted to reduce belief-consistent biases in interpretations of a polarized problem by making information easier to interpret. In the experiments, participants solved numerical problems that were either framed in a politically polarized (the effects of Muslim prayer rooms on support for Islamic extremism) or a neutral setting (the effects of a skin cream on skin rash). In both studies, the problems were presented twice, with the second presentation accompanied with an aid to facilitate problem-solving. In Experiment 1, this aid came in the form of an informative text on how to calculate the numbers to solve the problem. In Experiment 2, the aid provided participants with the first calculus necessary to solve the problem: transforming frequencies to percentages. Overall, results demonstrated belief-consistent responses in the polarized scenario when participants attempted to solve the first problem (higher accuracy when the correct conclusion was in line with participants’ ideology). Information on how to calculate the problem (Experiment 1) only slightly reduced the biased responses, whereas the added percentages (Experiment 2) led to a substantial reduction of the bias. Thus, we demonstrate that the facilitation of complex information on a polarized topic reduces biases in favor of rational reasoning.
Co-designing interventions to improve diets in rural communities
Authors: Needham Cindy , Partridge Stephanie R , Alston Laura , Rawstorn Jonathan C , Livingstone Katherine M 
Published: February 2025

Abstract
By involving stakeholders to identify issues, co-design facilitates the creation of solutions aligned with the community’s unique needs and values. However, genuine co-design with consumers across all stages of nutrition intervention research remains uncommon. The aim of this review was to examine notable examples of interventions to improve diets in rural settings that have been co-designed by rural communities. Six studies were identified reporting on community-based and digital interventions to improve diets in rural settings that have been co-designed by rural communities. The level of co-design used varied, with two interventions describing co-design workshops and focus groups over a period of between 6 and 11 months, and others not reporting details on the co-design process. Collectively, most interventions demonstrated positive impacts on dietary markers, including an increase in purchase of fruit and vegetable, an increase in percentage energy from nutrient dense foods and a decrease in intake of high fat meats. While these interventions show promise for improving diets in these under-served communities, it is widely recognised that there is a lack of dietary interventions genuinely co-designed with and for rural communities. Future research should build on these studies to co-design dietary interventions that integrate the benefits of both community-based and digital interventions.
Optimal sleep: a key element in maintaining a healthy bodyweight
Authors: Hall Wendy L 
Published: February 2025

Abstract
As obesity rates rise globally, addressing modifiable lifestyle factors, such as sleep, presents an opportunity for public health interventions. This review explores the growing evidence linking sleep duration, quality and timing with weight management and dietary behaviours throughout the life course. Observational studies associate short or irregular sleep with increased obesity risk, poor diet quality and metabolic disturbances. Plausible mechanisms include decreased physical activity, heightened hedonic and/or emotional eating, dysregulated appetite signals and circadian misalignment of metabolism, which contribute to a positive energy balance. Unravelling the bidirectional relationship between sleep and weight is challenging; poor sleep exacerbates weight gain, while obesity-related comorbidities such as obstructive sleep apnoea further impair sleep. Despite promising evidence from sleep-restriction studies showing increased energy intake, long-term randomised controlled trials (RCTs) examining interventions designed to improve sleep with weight management as an outcome are lacking. A handful of short-term interventions suggest benefits in reducing energy intake or improving dietary quality, but their effects on weight loss remain inconclusive. This review calls for robust, well-powered RCTs that integrate sleep, diet and physical activity interventions to evaluate the potential of sleep as a core component of obesity prevention and treatment strategies. Currently, there is insufficient evidence to support sleep-focused interventions as a mandatory element in clinical weight-management programmes.