bluuebunny/crossref_metadata_2025_split huggingface dataset:
MEDIATION OF TRIGUNA DOMINANCE BETWEEN RATIONALITY AND COPING HUMOR
Authors: Dr. Sudha Rathore  , Manvee Goyal  
Published: March 2024

Since the emergence of positive psychology, researchers are trying to establish relationships among positive psychological variables, individual characteristics and environmental factors, in order to find approaches to enhance well-being and psychological health.
In this regard, researchers have been adopting Eastern or Western perspective. Researches with Western perspective have always been in the forefront, while Eastern perspectives, although being age-old systems, have emerged in the spotlight in recent decades. These two perspectives well-define cultural differences while also accounting for individual differences, therefore, considered important to study.
Despite large number of studies on positive psychological variables, there is a need for establishing the role of cognitive aspects in positive psychological variables, furthermore so, in the light of Eastern perspective.
Thus, the present study aimed to explore the mediational role of Triguna dominance in relationship of Rationality with Coping Humor. The study sample consisted of 100 mid-adults (40-65 years).
Significant results of correlation and regression motivated to perform mediational analysis. The relationship of Rationality with Coping Humor was found to be 0.12 and 0.22 points higher as mediated by Rajas and Tamas guna respectively. Satva guna had no mediational role in their relationship.
Coping humor is a relatively new variable in positive psychology with limited research and theoretical bases. The results of the study can guide researchers in the exploration of the variable and development of the theories and models based on integrated research findings, furthermore so, with an Eastern perspective of Triguna. The study can be implied to various psychological fields, like counselling, rehabilitation psychology, health psychology, and others, to develop interventions and techniques to increase Rationality, Coping humor, and Satva guna while decreasing Rajas and Tamas guna to boost mental health and well-being.
SACRED GROVES: A BASTION OF BIODIVERSITY AND CULTURAL HERITAGE
Authors: Mehtab Singh Rathore  
Published: March 2024

Sacred groves, also known as sacred forests, are revered natural areas that hold deep spiritual and cultural significance for indigenous communities around the world. These enclaves of biodiversity have played a crucial role in conserving natural ecosystems, protecting endangered species, and preserving traditional knowledge and practices for centuries.
This paper explores the multifaceted significance of sacred groves, highlighting their contributions to biodiversity conservation, cultural heritage preservation, and the well-being of local communities. It delves into the intricate relationship between indigenous communities and their sacred groves, emphasizing the interconnectedness of nature, spirituality, and culture.
Drawing upon case studies from diverse regions, the paper showcases the tangible benefits of sacred groves in safeguarding threatened flora and fauna, maintaining ecosystem health, and providing ecological services such as soil and water conservation. It also underscores the cultural significance of these sites as repositories of traditional knowledge, sacred rituals, and artistic expressions.
The paper concludes by emphasizing the urgent need to recognize and protect sacred groves as invaluable assets for both biodiversity conservation and cultural heritage preservation. It advocates for collaborative approaches that empower indigenous communities in safeguarding their sacred groves and integrating their traditional knowledge into conservation efforts.
Machine learning rather than trial and error to close morphodynamical tuneable parameters: Application to a two-phase/two-layer model
Authors: Meurice Robin , Soares-Frazão Sandra 
Published: March 2024

ABSTRACT

Physics-based numerical models often depend on several parameters to close. Some of them can be expressed using established theoretical or empirical closure formulations. However, some others aggregate complex physical processes and are hence left as tuneable parameters, and can only be calibrated by trial and error. Yet, calibration data are not always available to do so, which prevents these models from being applied to wide ranges of laboratory or river flows. We hence propose a machine learning-based methodology to close any group of unclosed and correlated parameters, applied here to a two-phase/two-layer (2P2L) morphodynamical model. The methodology combines a numerical experiment with a known theoretical solution and machine learning. It is applied to the considered model to close two friction parameters for which generalizable and vastly acknowledged closure formulations lack in the literature. The resulting hybrid model, combining the original 2P2L model and the closure models, is tested against two laboratory dam break test cases. Despite excessive smoothness and underestimation of the concentration in sediment, the hybrid model performed similarly to other models from the literature requiring trial and error calibration and showed high stability and accuracy regarding the estimation of the water-sediment mixture's inertia.
Remediation of toluidine blue O dye from aqueous solution using surface functionalized magnetite nanoparticles
Authors: Jangra Arti , Kumar Ramesh , Singh Devender , Kumar Harish , Kumar Jai , Kumar Parvin , Kumar Suresh 
Published: March 2024

Abstract

In the current study, tannic acid-functionalized iron oxide nanoparticles have been synthesized using a cost-effective co-precipitation method and subsequently characterized using various instrumentation techniques such as Fourier transform infrared spectroscopy, X-ray diffractometer, field emission scanning electron microscopy, and thermal gravimetric analysis. Further, these surface-modified magnetite nanoparticles have been used for the adsorption of toluidine dye from an aqueous solution. The adsorption process was accompanied using batch procedure, and influences of several factors such as adsorbent dose, contact time, pH, temperature, and initial concentration of adsorbate were inspected concurrently. The maximum adsorption capacity of tannic acid-functionalized magnetite nanoparticles was found to be 50.68 mg/g. The adsorption process was observed to follow the Temkin isotherm model, whereas the kinetic study was well described by pseudo-second order. The thermodynamic study revealed the adsorption process to be endothermic and spontaneous in nature with a high degree of freedom between adsorbent and adsorbate. Therefore, the study indicated that the tannic acid-functionalized magnetite nanoparticles have promising adsorption capability and can be used as an excellent adsorbent for the removal of toluidine blue O dye from the aqueous solution.
Discovery of Multiple Effects of Reactive Oxygen Species on Lung
Adenocarcinoma at the Single-cell and Bulk Tissue Levels
Authors: Zhang Cong , Liu Bin , Xie Xianjin , Lu Degan 
Published: March 2024

Background::
Reactive oxygen species (ROS) are potential targets for treating
malignant tumors.

Aims::
The aim of this study was to probe into the mechanisms of disease development and treatment
in lung adenocarcinoma (LUAD).

Objective::
This study investigated the impact of ROS on the progression of LUAD at different
transcriptomic levels and analyzed key molecules involved in the regulation of LUAD.

Methods::
Single-cell RNA-seq (scRNA-seq) data of LUAD were clustered and annotated to determine
cell types. Scissor cells based on LUAD bulk transcriptome and epithelial scRNA-seq data
were used to classify subsets associated with ROS phenotypes. Least absolute shrinkage and selection
operator (LASSO) and stepwise multivariate regression analyses were performed between the
Scissor-positive and Scissor-negative epithelial cells to select key differentially expressed genes
(DEGs) for developing a ROS-related signature.

Results::
The ROS score was significantly negatively correlated with the overall survival (OS) of
LUAD. Seven cell types from the LUAD tissues were identified. The ROS-related gene signature
was significantly correlated with metabolism, tumor microenvironment (TME) indicators, and the
half-maximal inhibitory concentration (IC50) values of 10 drugs. The gene signature was verified
as an independent indicator for LUAD prognosis.

Conclusion::
The current study provided novel insights into the impact of ROS on LUAD pathology
at both single-cell and bulk-tissue levels, facilitating the prognostic evaluation and drug therapy
development for patients with LUAD.
Biofilm Formation in Mycobacterial Genus; Mechanism of Biofilm Formation and Anti-Mycobacterial Biofilm Agents
Authors: Nasrollahian Sina , Pourmoshtagh Hassan , Sabour Sahar , Hadi Nahal , Azimi Taher , Soleiman-Meigooni Saeed 
Published: March 2024

Abstract:
Mycobacterium tuberculosis, Mycobacterium leprae, and non-tuberculous mycobacteria
(NTM) are among the most significant human pathogens within the Mycobacterium genus.
These pathogens can infect people who come into contact with biomaterials or have chronic
illnesses. A characteristic pathogenic trait of mycobacteria is the development of biofilms,
which involves several molecules, such as the GroEL1 chaperone, glycopeptidolipids, and
shorter-chain mycolic acids. Bacterial behavior is influenced by nutrients, ions, and carbon
sources, which also play a regulatory role in biofilm development. Compared to their planktonic
phase, mycobacterial biofilms are more resilient to environmental stresses and disinfectants.
Mycobacteria that produce biofilms have been found in several environmental studies, particularly
in water systems. NTM can cause respiratory problems in individuals with underlying illnesses
such as cystic fibrosis, bronchiectasis, and old tuberculosis scars. Mycobacteria that grow
slowly, like those in the Mycobacterium avium complex (MAC), or rapidly, like Mycobacterium
abscessus, can be pathogens. Infections related to biomaterials represent a significant category
of biofilm-associated infections, with rapidly growing mycobacteria being the most frequently
identified organisms. A biofilm produced by M. tuberculosis can contribute to caseous necrosis
and cavity formation in lung tissue. Additionally, M. tuberculosis forms biofilms on clinical
biomaterials. Biofilm formation is a major contributor to antimicrobial resistance, providing
defense against drugs that would typically be effective against these bacteria in their planktonic
state. The antibiotic resistance of biofilm-forming microbes may render therapy ineffective, necessitating
the physical removal of biofilms to cure the infection. Recently, new approaches
have been developed with potential anti-biofilm compounds to increase treatment effectiveness.
Understanding biofilms is crucial for the appropriate treatment of various NTM diseases, and the
recent discovery of M. tuberculosis biofilms has opened up a new field of study. This review
focuses on the biofilm formation of the Mycobacterial genus, the mechanisms of biofilm formation,
and anti-mycobacterial biofilm agents.
Immunomodulatory Plant Natural Products as Therapeutics against
Inflammatory Skin Diseases
Authors: Sampath Kumar Nikhila , Reddy Navaneetha , Kumar Halmuthur , Vemireddy Sravanthi 
Published: March 2024

Abstract:
Frequently occurring inflammatory skin conditions such as psoriasis, dermatitis, acne,
including skin cancer, wounds and other disorders arising out of premature skin aging, deteriorate
skin health and adversely impact human life. Even though several synthetic compounds have
evolved for treating these skin conditions, natural-product-based therapeutics are gaining popularity
with growing evidence of their efficacy and safety for treating skin disorders. Many of these inflammatory
skin diseases have underlying disturbances in our immune system and immunomodulatory
natural products provide solutions for their effective treatment and aid in understanding the
underlying mechanism of such inflammatory skin conditions. Based on this premise, the present
review summarizes the possible application of plant-derived immunomodulatory compositions
and single molecules for treating inflammatory skin conditions. In vitro, in vivo and mechanistic
studies reported the application of selected plant-derived natural products for the treatment of inflammatory
skin disorders including, cancer and infections.

:
Several online databases including PubMed, Google Scholar, and Science Direct have been
searched for gathering the information covered in this review. Empirical studies demonstrated that
most of these natural compounds exhibited therapeutic properties through their immunomodulatory
and anti-inflammatory potential supplemented often with anti-microbial, anti-neoplastic, and anti-
oxidant activities. Overall, plant-based natural products discussed here are capable of modulating
the immune system to minimize or completely suppress the pro-inflammatory markers, scavenge
free radicals (ROS), prevent bacteria, fungal, and virus-derived skin infections and often
regress skin cancer through the induction of apoptosis. The challenges and opportunities associated
with the application of plant-based immunomodulators for skin applications and their safety
considerations are also discussed here. The present study indicated that immunomodulatory plant
natural products being biologically validated ligands against various biological targets manifested
in inflammatory skin diseases, offer an effective, safe and affordable treatment for such disorders
affecting skin health. However, further clinical evaluations are needed to substantiate these findings.
Design, Synthesis, Antitumor Activity Evaluation, and Molecular Dynamics
Simulation of Some 2-Aminopyrazine Derivatives
Authors: Cui Hangrui , Zhang Ruifeng , Xiong Xin , Cui Zhiwen , Min Zhijian , Liu Jinglong , Li Xunping , Min Zhenli 
Published: March 2024

Objective::
Cancer poses a great threat to human health, and effective drugs to treat it
are always needed. Several compounds containing a 2-aminopyrazine framework have been
identified as antitumor agents with SHP2 inhibition activities. This current work aimed to search
for more potent novel compounds possessing a 2-aminopyrazine moiety with antitumor activities.

Methods::
A series of 12 novel 2-aminopyrazine derivatives was synthesized, and their structures
were confirmed by spectroscopic techniques. The inhibitory activities of all the synthesized
compounds against MDA-MB-231 and H1975 cancer cell lines were evaluated by an
MTT assay. The most potent compound 3e was analyzed by flow cytometry. Subsequently,
computational studies were performed to investigate the possible antitumor mechanisms of
compound 3e.

Results::
The results indicated that compound 3e exhibited potent antitumor activities with IC50
values of 11.84±0.83μM against H1975 cells and 5.66±2.39μM against MDA-MB-231 cells,
which were more potent than the SHP2 inhibitor GS493 (IC50 = 19.08±1.01 μM against H1975
cells and IC50 = 25.02±1.47 μM against MDA-MB-231 cells). Further analysis by flow cytometry
demonstrated that compound 3e induced cell apoptosis in H1975 cells. The results of the
molecular docking and MD simulations, including RMSD, RMSF, PCA, DCCM and binding
energy and decomposition analyses, revealed that compound 3e probably selectively inhibited
SHP2.

Conclusion::
A new compound having a 2-aminopyrazine substructure with potent inhibitory
activities against the H1975 and MDA-MB-231 cancer cells was obtained, meriting further investigation
as an antitumor drug.
Green Method Synthesis of Magnetic Nanoparticles and its Functionalized MNPs for Knoevenagel Condensation Reaction
Authors: Shekhanavar Raju , Khatavi Santosh Y , Kamanna Kantharaju 
Published: March 2024

Background:
Knoevenagel condensation is an important C-C bond formation reaction
catalyzed by various homogeneous and heterogeneous acid-base catalysts.

Method:
The present work describes the eco-friendly preparation of magnetic nanoparticles Fe3O4
(MNPs) and its functionalization to Fe3O4@SiO2@SO3H. The prepared MNPs and their functionalized
materials were fully characterized by FT-IR, XRD, FE-SEM, HR-TEM, and VSM. Further
demonstrated application of these catalysts for the C-C bond formation reactions of Knoevenagel
condensation employing special aldehyde derivatives with malononitrile at room temperature gave
excellent product isolation.

Results:
The application of the prepared functionalized MNPs for the Knoevenagel condensation
was demonstrated by the reaction of various aryl/heterocyclic and cholesterol aldehyde with malononitrile
at room temperature stirring for about 30 min in ethanol solvent. The final product isolated
is confirmed by various spectroscopic techniques such as FT-IR, 1H-, & 13C-NMR, and mass spectrometry.
Furthermore, the selected compounds are screened for their photophysical properties, and
interestingly compound 3j showed good fluorescent properties.

Conclusion:
Overall the present work described a greener method preparation of MNPs, and its
functionalized employed as a heterogeneous catalyst for the Knoevenagel condensation of various
aryl/heterocyclic and cholesterol aldehyde with malononitrile. The method developed is simple,
easily separated catalyst by an external magnet, and recycled up to five cycles without any noticeable
change in the final product isolation. Further, the prepared derivatives screened for their photophysical
properties, and interestingly compound 3j showed good fluorescent properties.
MAGANG KEWIRAUSAHAAN FINISHING KERAMIK BAGI MAHASISWA PROGRAM STUDI PENDIDIKAN SENI KERAJINAN
Authors: Dewojati Darumoyo 
Published: March 2024

This program is aimed at giving sufficient practical experience in the form of knowledge, skills, and motivation and attitude appreciation, to the targeted students objectively, in connection with the entire practical works in a ceramic industry. This program is intended to internalize enterpreneurship values and spirit, that will have significant roles in preparing students facing the challenge dan jiwa enterpreneurship, that will provide significant practical experience to them in facing the challenge of finding suitable works after their graduation. The program involves 10 students of Craft Education Study Program, Faculty of Languages and Arts, Yogyakarta State University, and a finishing ceramic industry, i.e., Tunas Asri Keramik Yogyakarta, as a patner. The main methods and implementation of the program are conducted through lecturing and discussing, for the preparatory stage to give sufficient knowledge to the tagetted students, followed by the practical method as the implementation stage of the program by which the students are given the change to participatively involved in the industry. The latter method is conducted for 15 days with 8 hours effective working hours everyday. The result of the implementation of the program can be summarized as follows. Firstly, all the participants have actively involved in the entire program activities, namely, a) the preparatory lecturing on enterpreneurship topic in campus, b) learning and having practical activity of finishing ceramic prodct throuh various tecniques, c) learning the industrial management, and d) learning to write a proposal of establishing a new finishing ceramic industry. Secondly, all of the targeted students finish writing the proposal of establishing a new industry. This program is beneficial in giving practical experience to the students, consequently, this program should be continously developed and improved in the future.
PENINGKATAN KUALITAS LAYANAN PERPUSTAKAAN
Authors: Zuchdi Darmiyati 
Published: March 2024

Abstract This study was the broadening of a previous action research. The purpose of this study was to increase the interest of the students to read literature. This study was also aimed to explore the appropriateness of the literature for the students, the type of the assignment given by the lecturer, and the quality of circulation of the literature. This action research was done in nineteen undergraduate and one graduate courses from different study programs. The respondents of the study were the students and the lecturers of the courses. The data were collected using questionnaire and observation. The questionnaire was used to collect data from lecturers and from the students of the courses, while the observation was used to collect data about the activity of the students and the librarians. The data collected were analyzed quantatively, to describe of the percentage the respondents responding every question. The result of this study indicated that the majority of the students read the literature 1.5 hours per day outside the examination period and 3.5 hours during the examination period. The special service provided by IKIP Yogyakarta library combined with a systematic assignment from the lecturer made it possible for the students to be interested in reading the literature. This can be seen from the responses of the students, who generally viewed that most of the literatures were interesting, relevant, and very useful for the students to deepen their knowledge and skills. However, there were many of the students who found difficulties in understanding literature in English. The types of assignment given to the students were writing a book or report of reading, doing a discussion related to the literature, or writing a research proposal. The way the librarian handles the literature circulation was good. The condition of the reading room needed to be improved in order to be more comfortable. However that condition was better than the condition in the previous study. Keywords: reading interest, library service, and reserve literature.
PROFIL PEMBIAYAAN PENDIDIKAN UNTUK MENINGKATKAN MUTU DAN PEMERATAAN PENDIDIKAN DASAR
Authors: Suryono Yoyon 
Published: March 2024

Abstract Education budget is assumed to have a strong relationship with quality improvement and opportunity equalization especially at the basic education level. Therefore, it is necessary to identify an education-financial model that can improve uthe quality and accessibility of education. This research was an evaluative type of survey, 36 Public Elementary Schools and 18 Private Elementary Schools were included, and 162 respondents were purposively selected to find out the profile of education budget at basic education level and then a model of education budget was explored. The results of this study indicated that most of public elementary schools revenue mostly came from the parents and community sources. The biggest portion of expenditure was allocated for teacher salary , and only a small portion was allocated for instrumental activities and for procurement of facilities. The direct and indirect cost paid the parents was bigger than in private schools, and most of which was the direct cost. The unit cost for private school was bigger. This study also found out that there was relationship between the quality and accessibility on the one side, and the revenue and expenditure compositions at the school level on the other side. Based on the result of this study, basic policies are needed to decrease the school dependency on government sources, and to increase the community sources for increasing the basic education quality and accessibility. The core polity problem is “ Who is responsible for which budget component” Keywords: education cost, education budget, education finance, quality and accessibility, basic education, school effectiveness