bluuebunny/crossref_metadata_2025_split huggingface dataset:
Роль полиморфных вариантов генов цитохромов Р450, а также генов GSTP1 и MDR1 в развитии токсических осложнений при проведении программной противоопухолевой лекарственной терапии у пациентов с классической лимфомой Ходжкина
Authors: Шебуняева Яна Юрьевна , Горева О. Б. , Войтко М. С. , Гришанова А. Ю. , Вавилин В. А. , Поспелова Т. И. 
Published: April 2024

Background. Although considerable progress has been achieved in the treatment of classical Hodgkin lymphoma (cHL), toxic complications of program drug chemotherapy remain an issue. Standard cytostatic agents used in cHL therapy are metabolized in liver by the enzymes with Р450 cytochrome and GSTP1 gene-controlled synthesis. At the same time, the excretion of active metabolites of antitumor drugs is mediated by MDR1 coded P-glycoprotein. Polymorphisms[1] of these genes may change the processes of antitumor drug biotransformation and their metabolite excretion. Additionally, they may result in organo-toxic complications, disablement of patients, and even death.
Aim. To assess the role of polymorphisms in cytochrome genes Р450 as well as genes GSTP1 and MDR1 in organ toxicity dynamics during program chemotherapy (CT) in cHL patients.
Materials & Methods. The study enrolled 122 cHL patients treated with first-line regimens (ABVD, BEACOPP) of program drug chemotherapy. The patients were aged 18–78 years (median 35 years); there were 67 (54.9 %) women and 55 (45.1 %) men. In compliance with the NCCN CTC (2003) criteria of hepatotoxicity and practical recommendations for correcting cardiovascular toxicity of chemotherapy (2021), the signs of toxic liver and heart damage were assessed in all patients. PCR was used to analyze polymorphisms in cytochrome genes Р450 as well as genes GSTP1 and MDR1, their association with toxic complications of CT was analyzed.
Results. Drug-induced liver damage on program CT was identified in 80 % of cHL patients. The toxicity was increasing from CT cycle 1 to cycle 6 both on ABVD and BEACOPP. Complications grade 3/4 were observed only in BEACOPP recipients. Significant (p < 0.05) associations were found between hepatotoxic complications with increased cytolytic (AST, ALT) and cholestatic (ALP) values and polymorphic variants of MDR1. Significant (p < 0.05) reduction of left ventricle myocardium contractility in cHL patients was associated with Т-allele presence in genotypes CYP2D6*10 (rs1065852), CYP2C9*2 (rs1799853) and A-allele deletion in genotype CYP2D6_3 (rs4986774).
Conclusion. The identification of genetic predictors for toxic effects of program CT in cHL patients at the baseline examination can minimize the risks of drug chemotherapy-related adverse events and allow these patients to maintain a satisfactory quality of life.

[1] Gene polymorphism is a structural difference between alternative variants of a gene. Alternative variants of genes result from mutations.
Protección de datos personales recuperados en internet o dispositivos electrónicos en el proceso penal colombiano
Authors: Gómez Gómez Christian Camilo 
Published: April 2024

Esta investigación tiene como objeto de estudio el tratamiento de los datos personales en el proceso penal colombiano. Específicamente se analiza la diligencia del artículo 236 del código de procediendo penal, la recuperación de información dejada al navegar por internet en dispositivos electrónicos; se estudia la incidencia que tiene en la protección a la intimidad y privacidad de las personas, haciendo una crítica a las posiciones de la corte constitucional y corte suprema de justicia de lo que en la sociedad moderna se debe considerar, lo que es un teléfono celular y cómo en estos dispositivos electrónicos se pueden realizar hallazgos de datos personales.
Hospital Food Waste: Contributing Factors of Waste Generation and Strategy for Waste Minimization
Authors: Parlina Sri Umami , Herat Sunil 
Published: April 2024

The rapid and concerning increase in global food waste has garnered much attention due to its profound social, economic, and environmental ramifications worldwide. Healthcare facilities significantly influence the food chain because of their considerable resource consumption, waste generation, and procurement capabilities. Furthermore, insufficient waste management procedures can have significant ecological repercussions, predominantly due to the carbon emissions generated while disposing of healthcare waste, which also encompasses food waste. The matter of food waste in hospital food services is a complex and multifaceted problem, influenced by a multitude of factors. Conversely, endeavors to mitigate food waste within hospital settings encountered substantial obstacles. The challenges encountered pertain to every facet of hospital services through the emphasis on sustainability. This literature review aims to examine the literature on hospital food waste and identify the gaps in the existing resources that concentrate on the factors that lead to food waste being produced in healthcare facilities and the possible solutions to this problem. The findings point to the contributing factors of hospital food waste, including food quality and quantity, patient satisfaction, patient characteristics and clinical condition, meal times and food from outside, and the environment surrounding the hospital. It also indicates that implementing strategies such as improving the food delivery system, design of the menu, implementing room service model, improving food quality and the presentation of the meal, recruiting food dietitians, improving the dining environment as well as promoting reuse, recycling, composting, and anaerobic digestion can all help reduce food waste. Since food waste generation is context-specific, study outcomes may vary. Therefore, reduction strategies may vary by circumstance. Future research requires more advanced analytical methodologies and specific study designs, time frames, and locations.
Deep learning for automated trash screen blockage detection using cameras: Actionable information for flood risk management
Authors: Vandaele Remy , Dance Sarah L. , Ojha Varun 
Published: April 2024

ABSTRACT

Trash screens are used to prevent debris from entering critical parts of rivers. However, debris can accumulate on the screen and generate floods. This makes their monitoring critical both for maintenance and flood modeling purposes (e.g., local forecasts may change because the trash screen is blocked). We developed three novel deep learning methods for trash screen maintenance management consisting of automatically detecting trash screen blockage using cameras: a method based on image classification, a method based on image similarity matching, and a method based on anomaly detection. To facilitate their use by end users, these methods are designed so that they can be directly applied to any new trash screen camera installed by the end users. We have built a new dataset of labeled trash screen images to train and evaluate the efficiency of our methods, in terms of both accuracy and implications for end users. This dataset consists of 80,452 trash screen images from 54 cameras installed by the Environment Agency (UK). This work demonstrates that trash screen blockage detection can be automated using trash screen cameras and deep learning, which could have an impact on both trash screen management and flood modeling.
Compliance and adherence to hand hygiene practices for effective infection control
Authors: Sidiki Abubakari Ibn , Moomin Aliu , Lishchuk Alexandr Nikolaevich , Adam Maridia Kunateh , Al-Ariki Malik Kiaed , Ananko Vadim Alexandrovich , Baatiema Linus , Angmortey Nomo Richard , Adu-Gyamfi Paa Kofi Tawiah , Mensah Kwesi Boadu 
Published: April 2024

ABSTRACT
Hand hygiene (HH) is the most effective way to curb the spread of healthcare-associated infections. Nonetheless, healthcare personnel encounter difficulties in adhering to WHO HH recommendations. This study aimed to investigate HH compliance and adherence after the implementation of an action plan in a municipal hospital in Moscow. An initial evaluation of HH compliance among clinical health workers was carried out in June 2022 according to the WHO HH guidelines followed by a 3-month re-audit of HH practices. The results were compared to the baseline to evaluate compliance and adherence to HH among healthcare personnel. From June to September 2022, there were 2,732 moments of contact with patients or their immediate surroundings. The HH total compliance rate significantly (p &lt; 0.05) increased from 52.3% in June 2022 to 83.3% in September 2022 with a 75% overall total compliance rate. The profession-specific total compliance rate was highest among nurses (79.6%) and lowest among ancillary staff (69.7%). Staff were also more adherent to the before-moments compared to the after-moments of the HH guidelines. Monthly re-audits and providing feedback resulted in a significant improvement in compliance and adherence with HH guidelines after implementation of the action plan.
Machine learning approaches for improving precipitation forecasting in the Ambica River basin of Navsari District, Gujarat
Authors: Baudhanwala Divyang , Mehta Darshan , Kumar Vijendra 
Published: April 2024

Abstract
The article examines machine learning models for precipitation forecasting in the Ambica River basin, addressing the important requirement for accurate hydrological forecasts in water resource management. Using a comprehensive collection of meteorological variables such as temperature, humidity, wind speed, and precipitation, four separate models are used: Support Vector Regression (SVR), Random Forest (RF), Decision Tree (DT), and Multiple Linear Regression (MLR). These models’ performance is rigorously evaluated using various assessment indicators. The cross-correlation function (XCF) is used in this study to evaluate the correlations between climatic variables and precipitation. The XCF analysis reveals several noteworthy trends, such as a high link between maximum temperature and precipitation, with maxima consistently found at months across all four sites. Furthermore, relative humidity and wind speed have significant connections with precipitation. The findings highlight the value of machine learning approaches in improving precipitation forecast accuracy. The RF and SVR models typically outperform, with values ranging from 0.74 to 0.91. This impressive accuracy underlines their effectiveness in precipitation forecasting, beating competing models in both the training and testing stages. These findings have significant consequences for hydrological processes, notably in the Ambica River basin, where accurate precipitation forecasting is critical for sustainable water resource management.
Relationship between land use and water quality in a tropical urban catchment of the Congo Basin: A case study of N'Djili River catchment
Authors: Sani Zouera , Katshiatshia Haddy Mbuyi , M. Tshimanga Raphael , Basamba Twaha Ali , Odume Oghenekaro Nelson 
Published: April 2024

Abstract

This study focuses on N'Djili River catchment, a vital water source in Kinshasa that undergoes anthropogenic pressure and land use changes. The lower course of the river is particularly affected by uncontrolled urbanization, informal settlements, improper waste management practices, and vegetation degradation. The aim of this study is to determine the relationship between land use and river water quality in this catchment. Water samples were collected for physico-chemical and bacteriological analysis from 10 sampling sites along the river course. Land use categories were determined using Sentinel-2 land cover imageries and buffer scaling techniques. A redundancy analysis (RDA) was conducted to determine the relationship between land use categories and water quality variables. The laboratory analysis revealed physical, chemical, and biological pollution of the river waters. The RDA results showed that 70% of water quality parameters were explained by the studied land use categories. The urbanized area was the most significant explanatory variable at all buffer scales, negatively impacting water quality parameters. Conversely, trees and range lands had a positive impact on water quality. The study concludes that further research is needed to assess the extent of water pollution and develop integrated management strategies for minimizing pollution in this catchment.
Practical design of reservoirs for rainwater use in buildings in Brazil: behavioural analysis and modelling
Authors: da Silva Neto Vitor , Corrêa Flávia Vilela , Caminha Alice Raquel , Pinto Pâmela Rafanele França , da Silva Mateus Alexandre , Thebaldi Michael Silveira , de Deus Fábio Ponciano 
Published: April 2024

Abstract

The new version of NBR 15527 (ABNT 2019) determines that any methodology used for the design of rainwater reservoirs must be performed considering the demand for rainwater resources. Thus, the objective of this study was to develop mathematical models for the design of rainwater reservoirs in residential buildings for all Brazilian states. Different use scenarios were simulated, which included drinking water demands of 100, 150, 200 and 300 litres per capita and rainwater replacement for drinking water at rates of 25, 35, 45 and 55%, according to rainfall data from the last decade. The optimal and maximal volumes of each scenario were calculated using the yield after spill (YAS) behavioural method. Based on the values of the volumes obtained, the studied municipalities were grouped, and for each group, the practical models were adjusted and evaluated using the coefficient of determination (R²) and the root mean square error (RMSE). A good adherence of the models to the observed data was observed, which simplified the estimation of the volume for rainwater reservoirs; practical applications demand that designs use discreet daily rainfall values.
Clinical and experimental parallels in the substantiation of the method of hernioplasty of postoperative ventral hernias of median localization
Authors: Korobka V. L. , Tatyanchenko V. K. , Dabliz R. O. , Tolstopyatov S. V. , Gonchar M. V. , Kletz I. S. 
Published: April 2024

Objective: development, clinical application of a new original method of hernioplasty of median postoperative ventral hernias and biomechanical experimental substantiation of the effectiveness of this method.Materials and methods: the method of hernioplasty of median postoperative ventral hernias with strengthening of fascial-aponeurotic structures of the anterior abdominal wall was developed and clinically tested on 63 patients. An anatomical experiment was performed in which the biomechanical parameters of the reinforced scar-altered structures of the median parts of the anterior abdominal wall were studied according to the method developed by us.Results: an increase in the biomechanical parameters of the median structures reinforced by the original method with a frame thread was found: the strength limit of the fascia — by 59.4%, and the modulus of elasticity — by 40.2%, compared with the scar-altered fascia in herniators. These results suggest a confident prevention of recurrence of herniation when using this technique. This assumption was confirmed after the introduction of the technique into clinical practice. In all 63 observed patients, there is no recurrence of herniation for 1-5 years. There were no significant complications of the course of the early postoperative period associated with the applied method of plastic surgery. The method is characterized by material and financial accessibility, the absence of complex technical manipulations that increase the duration of hernioplasty.Conclusions: the effectiveness in preventing recurrence of herniation, accessibility and simplicity of the proposed method of surgical treatment of postoperative and recurrent ventral hernias allows us to recommend it for wide clinical use.
Dynamic assessment of T-lymphocytes and humoral immunity in patients with acute coronary syndrome, with and without COVID-19, depending on the content of CD3+CD8+T-lymphocytes
Authors: Safronova E. A. , Ryabova L. V. , Zurochka A. V. , Dobrynina M. A. , Zadorina E. V. 
Published: April 2024

Objective: to evaluate the dynamics of the T- and B-cell immunity in patients with acute coronary syndrome (ACS) who have and have not had COVID-19, depending on the number of CD3+CD8+T-lymphocytes.Materials and methods: 65 men with ACS who underwent coronary artery stenting were examined. Immunological parameters were studied using flow cytometry, a complete blood count at baseline and 28 days after admission.Results: The maximum troponin level was observed in individuals with ACS who had recovered from COVID-19 and had a normal level of CD3+CD8+T cells. Stent thromboses and deaths occurred only among patients with a history of COVID-19, mainly with reduced CD3+CD8+T- cells, for which indicators of immune status were determined over time. The absolute numbers of T lymphocytes, T helper cells, late activated T lymphocytes, B lymphocytes (CD3-CD19+CD5+), B lymphocytes (CD45+CD3-CD19+) were minimal in individuals with low CD3+CD8+ T lymphocytes who had previously suffered from COVID-19, and significantly increased in their dynamics after 28 days. Natural killer cells significantly increased in dynamics in patients with initially low and normal CD3+CD8+T-lymphocytes who suffered from COVID-19.Conclusions: after stenting of the coronary arteries over time, in people with reduced CD3+CD8+Tlymphocytes and patients with COVID-19, T-lymphocytes (CD45+CD3+CD19-), T-helper cells, CD3+CD8+T-lymphocytes significantly increased, T-NK lymphocytes, NK lymphocytes, late-activated T-lymphocytes, T-regulatory lymphocytes and late-activated T-regulatory cells, B-lymphocytes, immunoglobulin G and complement fragment C3a decreased. T-regulatory lymphocytes and late-activated T-regulatory cells were significantly reduced in patients without prior COVID-19 with baseline low CD3+CD8+T-lymphocytes. In individuals with normal CD3+CD8+T-lymphocytes who recovered from COVID-19, T-lymphocytes (CD45+CD3+CD19-), NK-lymphocytes, and late-activated T-lymphocytes increased over time.
New clinical and immunological aspects of acute urticaria in children
Authors: Maltsev S. V. , Sizyakina L. P. , Lebedenko A. A. , Averkina L. A. 
Published: April 2024

Objective: to study the features of the clinical picture and the innate immune response in children with various variants of the course of acute urticaria.Materials and methods: 236 children with acute urticaria were examined. Clinical research methods included an analysis of the medical history of life and disease, an objective examination of the child, immunological research methods consisted in determining the content of lactoferrin, IL-4, IL-6, IL-17, IFN-γ, TGF-β, the active form of VEGF-A by enzyme immunoassay of blood serum.Results: clinical and anamnestic data of various variants of the course of acute urticaria in children, depending on the values of UAS7, revealed the features of the course of the disease in childhood; in some patients, severe acute urticaria was an integral part of anaphylaxis of various origins; cytokine spectrum analysis records hyperproduction of IFNy in children with acute urticaria, regardless of the severity of its course, a decrease in IL levels-4 in the blood serum of children with all variants of acute urticaria, increased concentration of lactoferrin, IL-6, IL-17, significant hyperproduction of TGF-β, the active form of VEGF-A in severe acute urticaria.Conclusion: the revealed changes indicate an imbalance in the functioning of the innate link of the immune system, activation of the cytokine cascade of inflammation, which leads to the launch of regulatory mechanisms of the inflammatory process, while in childhood there is a clear dependence of the severity of the imbalance of the immune response and the severity of acute urticarial.
Rate of treatment demand of Omsk region population due to injuries caused by animals: dynamics and structure
Authors: Savkina E. S. , Poleshchuk E. M. , Sidorov G. N. 
Published: April 2024

Objective: to analyze the rate of treatment demand after contact with animals in the Omsk region.Materials and methods: we used data of rate of treatment demand of Omsk region population due to injuries caused by animals in 2009–2022. A descriptive-evaluative epidemiological research method was used. The characteristics of injuries from domestic owned (dogs and cats with an owner), domestic stray (stray dogs and cats) and wild (including synanthropic rodents) animals are analyzed.Results: in 2009–2022 in the Omsk region, 65142 people were injured by animals, which amounted to an average of 4653 complaints per year. Appeals from children aged 0–17 years old amounted to 36,5%, and from children aged 0–14 — 30,2% of the total. The leading role belongs to injuries caused by domestic animals — 67,1%, and of these, in 75,4% of cases — by dogs. An increase in calls regarding attacks by stray dogs has been established and is extremely pronounced regarding attacks by stray cats. The number of calls regarding bites from wild animals, namely squirrels and wild and synanthropic rodents, has increased significantly.Conclusions: In order to reduce the frequency of dangerous contacts with wild animals, in particular with squirrels, as well as with pets, it is necessary to carry out sanitary educational work with the population, especially children. The issue of installing warning boards in parks with a ban on hand-feeding squirrels, and installing feeding tables and feeders should be considered.
Epidemiological situation of natural focal infections in the Volgograd region in 2023
Authors: Smelyansky V. P. , Zhukov K. V. , Kargashin S. A. , Nikitin D. N. , Klimina I. A. , Taratutina M. N. , Romasova E. I. , Kondratenko E. V. , Bozhko V. G. 
Published: April 2024

Objective: analysis of epizootiological and epidemiological aspects of natural focal infections, namely plague, tularemia, HFRS, West Nile fever, Crimean hemorrhagic fever, Ixodic tick-borne borreliosis, Cu fever, leptospirosis and rabies, in the Volgograd region over 10 months in 2023.Materials and methods: the article analyzes the epidemiological manifestations of natural focal infections (NFI) in the Volgograd region for 10 months of 2023. The work uses official statistical data from institutions of Rospotrebnadzor of the Volgograd region on NFI for 2023. The main research method is epidemiological analysis.Results: the numbers of small mammals, potential carriers of NFI, on the territory of the Volgograd region in the 2023 season were within the same indicators of the previous year (SIPY), while the number of ticks in the spring-summer period was higher than the SIPY, but in the fall the number of arthropods in stationary points was lower than in previous seasons. The number of mosquitoes carrying arbovirus infections exceeded the long-term average. When studying environmental objects for the presence of markers of NFI pathogens, a slight decrease in the proportion of positive samples was noted compared to SIPY for all nosological forms. Over the 10 months of this year, there has been a deterioration in the epidemiological situation in the Volgograd region for several infections compared to the same period in 2022. There were 18 cases of West Nile fever (WNF), 10 cases of ixodid tick-borne borreliosis (ITB), and 6 cases of hemorrhagic fever with renal syndrome (HFRS). No patients with plague, tularemia, rabies, leptospirosis, Crimean hemorrhagic fever (CHF) and Q fever were identified.Conclusion: the presence of natural foci of dangerous infectious diseases of varying degrees of activity on the territory of the Volgograd region requires constant monitoring and an adequate response to changes in the foci in order to prevent complications of the epidemiological situation due to NFI.