bluuebunny/crossref_metadata_2025_split huggingface dataset:
Post hoc analysis of daratumumab plus lenalidomide, bortezomib and dexamethasone in Black patients from final data of the GRIFFIN study
Authors: Nooka Ajay K. , Kaufman Jonathan L. , Rodriguez Cesar , Jakubowiak Andrzej , Efebera Yvonne , Reeves Brandi , Wildes Tanya M. , Holstein Sarah A. , Anderson Larry D. , Badros Ashraf , Shune Leyla , Chari Ajai , Pei Huiling , Cortoos Annelore , Patel Sharmila , Lin Thomas S. , Voorhees Peter M. , Usmani Saad Z. , Richardson Paul G. 
Published: March 2024

SummaryDue in part to racial disparities and underrepresentation in clinical studies, optimal therapies for Black patients with multiple myeloma remain undefined. This final analysis of GRIFFIN by race showed that the addition of daratumumab (D) to lenalidomide/bortezomib/dexamethasone (RVd) provides clinical benefit among both Black and White transplant‐eligible newly diagnosed patients compared with RVd alone. However, Black patients were more likely to discontinue ≥1 drug due to treatment‐emergent adverse events. In summary, these findings suggest a benefit of D‐RVd front‐line therapy among Black and White patients and underscore the importance of equitable treatment access for all patients.
Usefulness of cardiopulmonary exercise test combined with exercise stress echocardiography in mild chronic thromboembolic pulmonary disease
Authors: Kim Min Sun , Jeon Kina , Kim Eun Kyoung , Park Taek Kyu , Park Hye Yun , Yang Jeong Hoon , Park Sung‐Ji , Lee Sang‐Chol , Park Seung Woo , Kim Duk‐Kyung , Chang Sung‐A 
Published: March 2024

AbstractPurposeChronic thromboembolic pulmonary disease (CTEPD) can lead to exercise limitations even without right ventricular (RV) dysfunction or pulmonary hypertension at rest. Combining exercise stress echocardiography with cardiopulmonary exercise testing (ESE‐CPET) for RV function and pressure changes combined measuring overall function may be useful for CTEPD evaluation. This study aims to investigate CPET and ESE results to elucidate the mechanisms of exercise limitation in mild CTEPD cases.MethodsAmong our CTEPD registry, 50 patients who performed both right heart catheterization data of mild disease (less than 30 mm Hg of mean pulmonary arterial pressure (mPAP)) and ESE‐CPET were enrolled. Echocardiography and CPET‐derived parameters were compared with hemodynamic parameters measured through right heart catheterization.ResultsPeak VO2 (maximal oxygen consumption) was decreased in overall population (71.3 ± 16.3% of predictive value). Peak VO2 during exercise was negatively correlate with mPAP and pulmonary vascular resistance at rest. A substantial increase in RV systolic pressure (RVSP) was observed during exercise (RVSP: pre‐exercise 37.2 ± 11.8 mm Hg, postexercise 64.3 ± 24.9 mm Hg, p‐value < .001). Furthermore, RV function deteriorated during exercise when compared to the baseline (RV fractional area change: 31.5 ± 10.0% to 37.8 ± 7.0%, p‐value < .001; RV global longitudinal strain: −17.1 ± 4.2% to −17.7 ± 3.3%, p‐value < .001) even though basal RV function was normal. While an excessive increase in RVSP during exercise was noticed in both groups, dilated RV and RV dysfunction during exercise were demonstrated only in the impaired exercise capacity group.ConclusionCTEPD patients with mild PH or without PH exhibited limited exercise capacity alongside an excessive increase in RVSP during exercise. Importantly, RV dysfunction during exercise was significantly associated with exercise capacity. ESE‐CPET could aid in comprehending the primary cause of exercise limitation in these patients.
Revisiting the Usage of Alpha in Scale Evaluation: Effects of Scale Length and Sample Size
Authors: Xiao Leifeng , Hau Kit‐Tai , Wang Melissa Dan 
Published: March 2024

AbstractShort scales are time‐efficient for participants and cost‐effective in research. However, researchers often mistakenly expect short scales to have the same reliability as long ones without considering the effect of scale length. We argue that applying a universal benchmark for alpha is problematic as the impact of low‐quality items is greater on shorter scales. In this study, we proposed simple guidelines for item reduction using the “alpha‐if‐item‐deleted” procedure in scale construction. An item can be removed if alpha increases or decreases by less than .02, especially for short scales. Conversely, an item should be retained if alpha decreases by more than .04 upon its removal. For reliability benchmarks, .80 is relatively safe in most conditions, but higher benchmarks are recommended for longer scales and smaller sample sizes. Supplementary analyses, including item content, face validity, and content coverage, are critical to ensure scale quality.
Magnetic resonance imaging fingerprints of status epilepticus: A case–control study
Authors: Bosque Varela Pilar , Tabaee Damavandi Payam , Machegger Lukas , Prüwasser Tanja , Zimmermann Georg , Oellerer Andreas , Steinbacher Jürgen , McCoy Mark , Pfaff Johannes , Trinka Eugen , Kuchukhidze Giorgi 
Published: March 2024

AbstractObjectiveStatus epilepticus (SE) is frequently associated with peri‐ictal magnetic resonance imaging (MRI) abnormalities (PMA). However, the anatomical distribution of these alterations has not been systematically studied. The aim of this study was to assess the localization patterns of PMA in patients with SE.MethodsIn this prospective case–control study, we compared the distribution and combinations of diffusion‐restricted PMA to diffusion‐restricted lesions caused by other neurological conditions. All patients of the SE group and the control group underwent MRI including a diffusion‐weighted imaging sequence. Patients with SE were imaged within 48 h after its onset.ResultsWe enrolled 201 patients (51 with SE and 150 controls). The most frequent locations of PMA in SE were cortex (25/51, 49%), followed by hippocampus (20/51, 39%) and pulvinar of thalamus (10/51, 20%). In the control group, the cortex was involved in 80 of 150 (53%), white matter in 53 of 150 (35%), and basal ganglia in 33 of 150 (22%). In the control group, the pulvinar of thalamus was never affected and hippocampal structures were rarely involved (7/150, 5%). Involvement of the pulvinar of thalamus and the hippocampus had high specificity for SE at 100% (95% confidence interval [CI] = 98–100) and 95% (95% CI = 91–98), respectively. The sensitivity, however, was low for both locations (pulvinar of thalamus: 20%, 95% CI = 10–33; hippocampus: 39%, 95% CI = 26–54).SignificanceDiffusion‐restricted MRI lesions observed in the pulvinar of thalamus and hippocampus are strongly associated with SE. These changes may help physicians in diagnosing SE‐related changes on MRI in an acute setting, especially in cases of equivocal clinical and electroencephalographic manifestations of SE.
Status epilepticus: Is there a Stage 1 plus?
Authors: Magro Giuseppe , Laterza Vincenzo 
Published: March 2024

AbstractIn status epilepticus (SE), “time is brain.” Currently, first‐line therapy consists of benzodiazepines (BDZs) and SE is classified by the response to treatment; stage 2 or established SE is defined as “BDZ‐resistant SE.” Nonetheless, this classification does not always work, especially in the case of prolonged convulsive SE, where many molecular changes occur and γ‐aminobutyric acid signaling becomes excitatory. Under these circumstances, BDZ therapy might not be optimal, and might be possibly detrimental, if given alone; as the duration of SE increases, so too does BDZ resistance. Murine models of SE showed how these cases might benefit more from synergistic combined therapy from the start. The definition of Stage 1 plus is suggested, as a stage requiring combined therapy from the start, which includes prolonged SE with seizure activity going on for >10 min, the time that marks the disruption of receptor homeostasis, with increased internalization. This specific stage might require a synergistic approach from the start, with a combination of first‐ and second‐line treatment.
Assessing short‐term and long‐term security and efficacy of anterior nucleus of the thalamus deep brain stimulation for treating drug‐resistant epilepsy: A systematic review and single‐arm meta‐analysis
Authors: Verly Gabriel , Oliveira Leonardo de Barros , Delfino Thiffany , Batista Sávio , Lopes Thiago , Carvalho Vitória , McBenedict Billy , Oliveira Matheus , Bertani Raphael , Martins da Cunha Pedro Henrique , Paiva Wellingson , Lima Pessoa Bruno 
Published: March 2024

AbstractDeep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT) is a widespread invasive procedure for treating drug‐resistant epilepsy. Nonetheless, there is a persistent debate regarding the short‐term and long‐term efficacy and safety of ANT‐DBS. Thus we conducted a systematic review and meta‐analysis. Following Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA), we searched PubMed, Cochrane, Embase, and Web of Science for studies treating refractory epilepsy with ANT‐DBS. Short‐term analysis was considered for studies with a mean follow‐up of 3 years or less. The following outcomes were assessed for data extraction: procedure responders and nonresponders, increased seizure frequency, complications, and procedure‐related mortality. Of 650 studies, 25 fit our inclusion criteria, involving 427 patients. Previous surgical treatments have been reported in 214 patients (50.1%) and a median average baseline seizure frequency of 64.9 monthly seizures. In the short‐term analysis, we observed a proportion of 67% (95% confidence interval [CI] 54%–79%) of responders and 33% (95% CI 21%–46%) of nonresponders. In addition, 4% (95% CI 0%–9%) of the patients presented increased seizure frequency. In the long‐term analysis, we observed 72% (95% CI 66%–78%) responders and 27% (95% CI 21%–34%) nonresponders. Moreover, there was a 2% (95% CI 0%–5%) increase in seizure frequency. No procedure‐related mortality was reported at any follow‐up. ANT‐DBS effectively treats refractory epilepsy, with lasting short‐term and long‐term benefits. It remains safe and efficient despite complications, showing no procedure‐linked fatalities, high patient responsiveness, and minimal increased seizures. Consistent results over time and low morbidity/mortality rates emphasize its worth. Further research is necessary to diminish the discrepancy among results.
Expanding the family circle: Local in‐law relationships and their role in supporting foreign spouses
Authors: Ang‐Tan Ruth , Choo Hyekyung 
Published: March 2024

AbstractObjectiveThis study investigates the role of local families‐in‐law in the lives of foreign spouses from low‐income, cross‐national families in Singapore, focusing on their potential as a source of support for social integration and access to resources.BackgroundForeign spouses in Singapore face challenges related to social integration and access to resources, and local in‐law relationships have been identified as a potential source of support.MethodIn‐depth interviews with 18 Chinese‐national foreign spouses were analyzed using thematic analysis.ResultsSiblings‐in‐law were vital to foreign spouses, providing more emotional and practical support than parents‐in‐law. Local in‐law relationships influenced foreign spouses' identification with locals, and the local in‐laws' familiarity with local resources and networks facilitated access to formal and informal services, contributing to equitable outcomes.ConclusionLocal families‐in‐law play a critical role in the lives of foreign spouses in Singapore, especially siblings‐in‐law. The findings highlight the potential of local in‐law relationships as a support system for cross‐national families.ImplicationsThe study's findings can inform policies and practices that support the well‐being of cross‐national families. Policymakers and practitioners should recognize the potential of local in‐law relationships and develop programs to strengthen them.
Emotion in public involvement: A conceptual review
Authors: Liabo Kristin , Asare Lauren , Ruthen Philip , Burton Julia , Staunton Pamela , Day Joanne 
Published: March 2024

AbstractBackgroundExperiential knowledge can aid in designing research by highlighting what an idea looks like from a patient and carer perspective. Experiential knowledge can be emotional, and this can create challenges at formal research meetings.ObjectiveThe aim of this study was to consider the role of emotions in public involvement.MethodsThis is a conceptual review informed by relevant literature and reflection within the author team. A structured Scopus search was conducted in November 2021 and December 2022, identifying 18 articles that presented findings from patient and public involvement (PPI) research related to ‘emotion’. We complemented the search with theory‐generating articles related to the role of emotion and emotional labour in human life.FindingsStudy findings from the structured search were tabulated to identify recurring themes; these were as follows: emotional connections to the research topic can cause stressful as well as cathartic experiences of PPI, ‘emotional work’ is part of PPI when people are contributing with their experiential knowledge and the emotional aspect of ‘lived experience’ needs to be recognised in how PPI is planned and facilitated. These points were considered in relation to theoretical works and experiences within the author team.Discussion‘Emotion work’ is often required of public collaborators when they contribute to research. They are asked to contribute to research alongside researchers, with knowledge that often contains emotions or feelings. This can be both upsetting and cathartic, and the environment of the research study can make the experience worse or better.ConclusionsThe emotional component of experiential knowledge can be challenging to those invited to share this knowledge. It is imperative that researchers, research institutions and health and care professionals adjust research meeting spaces to show an awareness of the emotional labour that is involved in PPI.Patient or Public ContributionThis review was initiated after a meeting between carers and family members of residents in care homes and researchers. The review is co‐written by a group of three researchers and three carers and family members. Regular online meetings were held during the draft stages to incorporate people's views and ideas. Data extracted from the review were presented to the group of public collaborators in a variety of formats (e.g., posters, slideshows, text and verbally) to facilitate shared sense‐making and synthesis of the literature.
Association of Monocyte Count With Lung Function and Exercise Capacity Among Hospitalized COVID‐19 Survivors: A 2‐Year Cohort Study
Authors: Gu Xiaoying , Huang Lixue , Li Xia , Zhou Yuting , Zhang Hui , Wang Yeming , Cui Dan , Yu Ting , Wang Yimin , Cao Bin 
Published: March 2024

ABSTRACTBackgroundAbnormal changes of monocytes have been observed in acute COVID‐19, whereas associations of monocyte count with long COVID were not sufficiently elucidated.MethodsA cohort study was conducted among COVID‐19 survivors discharged from hospital. The primary outcomes were core symptoms of long COVID, distance walked in 6 min, and lung function, and the secondary outcomes were health‐related quality of life and healthcare use after discharge. Latent variable mixture modeling was used to classify individuals into groups with similar trajectory of monocyte count from discharge to 2‐year after symptom onset. Multivariable adjusted generalized linear regression models and logistic regression models were used to estimate the associations of monocyte count trajectories and monocyte count at discharge with outcomes.ResultsIn total, 1389 study participants were included in this study. Two monocyte count trajectories including high to normal high and normal trajectory were identified. After multivariable adjustment, participants in high to normal high trajectory group had an odds ratio (OR) of 2.52 (95% CI, 1.44–4.42) for smell disorder, 2.27 (1.27–4.04) for 6‐min walking distance less than lower limit of normal range, 2.45 (1.08–5.57) for total lung capacity (TLC) < 80% of predicted, 3.37 (1.16–9.76) for personal care problem, and 1.70 (1.12–2.58) for rehospitalization after discharge at 2‐year follow‐up compared with those in normal trajectory group. Monocyte count at discharge showed similar results, which was associated with smell disorder, TLC < 80% of predicted, diffusion impairment, and rehospitalization.ConclusionsMonocyte count may serve as an easily accessible marker for long‐term management of people recovering from COVID‐19.
The perceived helpfulness and acceptability of a bespoke psychological therapy service for registered nurses experiencing psychological distress: A qualitative study
Authors: Whybrow Dean , Jones Bethan , Temeng Eunice , Dale Carys , Bundy Chris , Watts Tessa 
Published: March 2024

AbstractAimTo understand the perceived helpfulness and acceptability of a bespoke psychological therapy service for registered nurses. The service provided a free and confidential specialist mental health service to all healthcare professionals, including nurses and nursing students.DesignAn exploratory study using a descriptive qualitative approach.MethodsA purposive sample of 20 registered nurses accessing a bespoke psychological therapy service in Wales participated in audio‐recorded semi‐structured interviews in January 2022. Transcribed data were analysed using reflexive thematic analysis.ResultsFour interrelated themes were identified from the data analysis: COVID [SARS‐CoV‐2] changed things; You're a nurse, you're human; I've got ‘me’ back; and pretty close to miracle workers.ConclusionParticipants attempted to live up to an idealized image of a nurse, generating self‐stigmatizing beliefs that negatively affected their mental health. The psychological therapy service enabled participants to put their roles into perspective, that is, separate themselves from their role, be vulnerable, and develop confidence and adaptive coping strategies. Participants valued the minimal barriers and ease of access to support.Implications for the Profession and/or Patient CareThe complex relationship between nurse identity and the challenges of the workplace needs to be central to nurse education. Nurses can benefit from rapid access to a timely, confidential, and independent self‐referring psychological therapy service.ImpactThis qualitative study explored the helpfulness and accessibility of psychological support for nurses. The main themes were that COVID changed things; You're a nurse, you're human; I've got ‘me’ back; and pretty close to miracle workers. The findings will impact how nurses are supported in the United Kingdom and worldwide.Reporting MethodThis report adheres to the standards for reporting qualitative research (SRQR).Patient or Public ContributionNo patient or public contribution.
The Revival of Sorbents in Chronic Dialysis Treatment
Authors: Kooman Jeroen Peter 
Published: March 2024

ABSTRACTInterest in the use of sorbents in chronic dialysis treatment has undergone a revival in the last decades, for which two major factors are responsible. The first is the potential of sorbents as adjunct therapy for the removal of substances that are difficult to remove by conventional dialysis therapies. The second is their use in regeneration of dialysate, which is of pivotal importance in the design of portable or even wearable treatments, next to the potential for reducing water use during conventional dialysis treatment. Sorbent‐enhanced dialysis with synthetic polymers was associated with a reduction in inflammatory parameters as compared to hemodialysis and even associated with improved survival in smaller studies, although this needs to be confirmed in large randomized trials. Incorporation of sorbents within a dialysis membrane (mixed matrix membrane) appears a promising way forward to reduce the complexity and costs of a dual therapy but needs to be tested in vivo. For regeneration of dialysate, at present, a combination of urease, zirconium‐based sorbents, and activated charcoal is used. Next to sodium release by the sorbent in exchange for ammonium and the CO2 release by the hydrolysis of urea has been a bottleneck in the design of wearable devices, although short‐term trials have been performed. Still, for widespread and flexible application of sorbent‐assisted portable or wearable devices, a direct urea sorbent would be a major asset. In the near future, it will likely become apparent whether sorbent‐assisted dialysis techniques are feasible for routine implementation in clinical practice.
New Caledonian rovers and the historical biogeography of a hyper‐diverse endemic lineage of South Pacific leaf beetles
Authors: Platania Leonardo , Cardoso Anabela , Anderson Mark , Fikáček Martin , Gauthier Jérémy , Hendrich Lars , Mille Christian , Morii Yuta , Reid Chris A. M. , Seidel Matthias , Morgan‐Richards Mary , Trewick Steven A. , Toussaint Emmanuel F. A. , Gómez‐Zurita Jesús 
Published: March 2024

AbstractSouth Pacific archipelagos are central in the biogeographic debate on the relative importance of vicariance and dispersal in shaping the distribution of species. However, each taxonomic group was subject to different processes and histories, and here, we reveal the historical biogeography of the diverse Eumolpinae leaf beetles, widely distributed in the region. Extensive taxon sampling focusing on South Pacific Eumolpinae was used to infer the first molecular phylogeny of the group using three single‐copy protein‐coding nuclear and two mitochondrial markers. Upon assessing the clade of interest for lineage‐specific variation in substitution rates, the age of the most recent common ancestors was estimated using out‐group calibration and multi‐gamma site models (MGSMs). Biogeographic analyses used standard event‐based inferences also incorporating phylogenetic uncertainty. Zealandian Eumolpinae are monophyletic and appear to have split from their global relatives in the transition from the Cretaceous to the Paleogene. Variation in the rates of molecular evolution affected the in‐group stem branch, with a significant drop in the substitution rate, and the MGSM correction recovered the crown age of Zealandian Eumolpinae during the Late Eocene–Oligocene transition. Biogeographic inference resolved the origin of the radiation in New Caledonia, favouring a null model without island age constraints, and repeated dispersal events to the other islands, including three independent but synchronous colonisations of New Zealand during the Miocene. New Caledonia, with a highly diverse Eumolpinae fauna of uncertain origin, acted as a hub and pump of biodiversity of these beetles in the entire South Pacific region, sending migrants to other islands through long‐distance dispersal with lineages establishing when land became available.