bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patient satisfaction and their determinants in outpatient department of a tertiary public hospital in Nepal: a cross-sectional study
Authors: Bhatt Laxman Datt , Ghimire Sandhaya , Khanal Kabita 
Published: February 2024

Abstract
Background
Patient satisfaction is a vital metric for assessing healthcare quality and delivering patient-centered care. It can predict service utilization patterns by determining healthcare users’ contentment with their providers. Consequently, evaluating patient satisfaction and its underlying factors is crucial to maintaining the quality of healthcare services. The present study aimed to assess patient satisfaction and its determinants in a tertiary care public hospital in Nepal. In this research, a cross-sectional design was employed to examine patient satisfaction within the Outpatient Department of Mental Hospital Lagankhel, Nepal. The study adopted a systematic random sampling approach for respondent selection, and stringent measures were implemented to uphold the validity and reliability of the collected data. To assess patient satisfaction comprehensively, the Patient Satisfaction Questionnaire-III (PSQ-III), developed by the RAND Corporation, was employed in conjunction with relevant sociodemographic variables. Utilizing mean scores and percentages, we calculated satisfaction levels across various dimensions. Additionally, a multinomial logistic regression analysis was conducted to investigate the relationships between patient satisfaction dimensions and sociodemographic characteristics.

Results
This study encompassed perspective of 206 participants, with 57.3% representing patient relatives and 51% being male, median age of 32 years (standard deviation: 12.53). Notably, patients reported higher levels of satisfaction, particularly within the interpersonal relationship dimension, while the technical quality domain received comparatively lower satisfaction ratings. Multinomial logistic regression analysis underscored the significance of sociodemographic factors in shaping patient satisfaction, with age (p = 0.008), type of residence (p = 0.001), occupation (p = 0.0019), income status (p = 0.014), time to reach the healthcare facility (p = 0.013), and insurance enrollment status (p = 0.017) all demonstrating significant associations. These findings illuminate the intricate qualities of patient satisfaction within our healthcare context, offering actionable insights for enhancement and guiding the trajectory of future research endeavors.

Conclusions
Overall patient expressed satisfaction with service provided by tertiary care hospital, however continuous improvement remains essential. Conducting large-scale, nationwide studies across hospital tiers is vital. This data-driven approach empowers policymakers to allocate resources effectively, inform decision-making, and enact policies that exceed patient expectations, fostering a healthcare system of unparalleled excellence.
Combinatorial high throughput methodologies: the potentials in heterogeneous catalysts synthesis, screening and discovery—a review
Authors: Emmanuel Jovine Kamuhabwa 
Published: February 2024

Abstract
Background
Catalysis represents a critical field that greatly contributes to human living, technology, economic growth and the environment. Compact catalysts have frequently been applied in manufacturing a range of substances and fuels, thus essentially subsidising income and good living. Catalysts offer significant ecological profits, such as catalytic transformers, fuel cell technology, chemical production and environmental cleaning in automobiles. Still, the use of catalysts is anticipated to raise due to the need to discover ecologically responsive production pathways and affordable products.

Main body of the abstract
Since its discovery, catalysis has played a vital role in a range of fields, from industrial production, sustainable energy strategy and environmental cleaning to the pharmaceutical industry. The discovery and use of catalysts mark a critical aspect in chemistry due to the raising need for greater output plus effectiveness in industry and cleaner production. Despite their importance, the invention of catalysts remained a challenge as it relied on trial-and-error tactics. Customarily, catalysts were developed using various tiresome, time-wasting and usually one-at-a-time techniques characterised and screened for activity and modified until no extra improvements were necessary. However, with the advancement in science and technology, catalyst discovery has been made more accessible and faster through combinatorial techniques. Combinatorial experimentation technologies in chemistry are a fast emerging field that includes the formulation and fast creation of a combination of material libraries and parallel screening for particular chemical or physical characteristics of concern in a general economical and compelling style. These techniques in heterogeneous catalysis are essential for the quick invention of catalysts and for improving the available ones. The rapid and economic invention of catalysts and optimisation of the available ones attract much industrial interest.

Short conclusion
The present review uncovers catalysis development, progress, history and some applications. The latest developments and challenges associated with using high throughput experimentation techniques in synthesising, optimising, discovering and screening catalysts are discussed. A high throughput experimentation approach is potential in catalysis and is promising.
Virome characterization of diarrheic red-crowned crane (G. japonensis)
Authors: Cui Ning , Yang Xiao , Sui Hong , Tan Liugang , Wang Weihua , Su Shuai , Qi Lihong , Huang Qinghua , Hrabchenko Nataliia , Xu Chuantian 
Published: February 2024

Abstract
Background
The red-crowned crane is one of the vulnerable bird species. Although the captive population has markedly increased over the last decade, infectious diseases can lead to the death of young red-crowned cranes while few virological studies have been conducted.

Methods
Using a viral metagenomics approach, we analyzed the virome of tissues of the dead captive red-crowned crane with diarrhea symptoms in Dongying Biosphere Reserve, Shandong Province, China and feces of individual birds breeding at the corresponding captive breeding center, which were pooled separately.

Results
There is much more DNA and RNA viruses in the feces than that of the tissues. RNA virus belonging to the families Picornaviridae, and DNA viruses belonging to the families Parvoviridae, associated with enteric diseases were detected in the tissues and feces. Genomes of the picornavirus, genomovirus, and parvovirus identified in the study were fully characterized, which further suggested that infectious viruses of these families were possibly presented in the diseased red-crowned crane.

Conclusion
RNA virus belonging to the families Picornaviridae, and DNA viruses belonging to the families Genomoviridae and Parvoviridae were possibly the causative agent for diarrhea of red-crowned crane. This study has expanded our understanding of the virome of red-crowned crane and provides a baseline for elucidating the etiology for diarrhea of the birds.
The spin transport properties of Ni(111)/SnSe/Ni(111) lateral tunnel junction
Authors: Zhai Ming-Xing , Chen Ming-Yan , Zheng Xiao-Long , Zhou JiaoJiao 
Published: February 2024

Abstract
Spin-resolved transport properties of the armchair-edged SnSe lateral contact with two magnetic Ni(111) leads are investigated by density functional theory combined with nonequilibrium Green's function method. The spin-polarized currents, magnetoresistances and k-resolved transmission spectrums are simulated in spin parallel and antiparallel configurations. It is found that the heterostructure exhibits a stable spin injection efficiency which can reach up to 80% at low bias range in spin parallel configuration, suggesting the large spin-diffusion length of SnSe. The magnetoresistance can be maintained stably at about 40% at a wide bias range. These results make SnSe material possible to be used in spintronic devices.
Moon-like Facies by Glucocorticoid Is Associated With the Development of Diabetes and Body Image Disturbance
Authors: Tsutsumi Takahiro , Nakagomi Daiki , Kobayashi Kei , Hanai Shunichiro , Kobayashi Yoshiaki , Ito Ryosuke , Ishii Toshihisa , Okuma Hideyuki , Uchinuma Hiroyuki , Ichijo Masashi , Tsuchiya Kyoichiro 
Published: February 2024

Abstract

Context
Moon-like facies (MLF) are a typical side effect of glucocorticoid (GC) therapy; however, its predisposing factors, relationship with GC-induced complications, and effects on body image are not well understood.

Objective
This study aimed to determine the predisposing factors for MLF during GC therapy; its association with GC-induced diabetes, hypertension, and dyslipidemia; and its effects on body image.

Methods
This prospective observational study spanned 24 weeks and targeted patients who received GC therapy at the University of Yamanashi Hospital from June 2020 to August 2022. The MLF was defined based on the following 3 factors: (1) an increase in facial measurement lengths, (2) subjective facial changes by patients’ self-assessment using a visual analog scale; (3) objective and qualitative facial changes assessed by physicians. We examined the predisposing factors for MLF and the association of MLF with GC-induced diabetes, hypertension, dyslipidemia, and body image.

Results
The cumulative incidence rate of MLF at 24 weeks was 37.6%. Predisposing factors for MLF were an initial oral prednisolone dosage of ≥ 30 mg/day [odds ratio (OR) 63.91, 95% confidence interval (CI) 5.82-701.81] and female (OR 6.66, 95% CI 1.35-32.79). MLF showed a significant association with the onset of GC-induced diabetes (OR 6.58, 95% CI 1.25-34.74). MLF was also an independent factor contributing to body image disturbance (β = −18.94, P = .01).

Conclusion
MLF contributes to body image disturbance and is associated with the development of GC-induced diabetes; therefore, it is clinically important as a physical manifestation of GC therapy.
Functional consequences of somatic polyploidy in development
Authors: Darmasaputra Gabriella S. , van Rijnberk Lotte M. , Galli Matilde 
Published: February 2024

ABSTRACT
Polyploid cells contain multiple genome copies and arise in many animal tissues as a regulated part of development. However, polyploid cells can also arise due to cell division failure, DNA damage or tissue damage. Although polyploidization is crucial for the integrity and function of many tissues, the cellular and tissue-wide consequences of polyploidy can be very diverse. Nonetheless, many polyploid cell types and tissues share a remarkable similarity in function, providing important information about the possible contribution of polyploidy to cell and tissue function. Here, we review studies on polyploid cells in development, underlining parallel functions between different polyploid cell types, as well as differences between developmentally-programmed and stress-induced polyploidy.
Structure-based engineering of Tor complexes reveals that two types of yeast TORC1 produce distinct phenotypes
Authors: Kamada Yoshiaki , Umeda Chiharu , Mukai Yukio , Ohtsuka Hokuto , Otsubo Yoko , Yamashita Akira , Kosugi Takahiro 
Published: February 2024

ABSTRACT
Certain proteins assemble into diverse complex states, each having a distinct and unique function in the cell. Target of rapamycin (Tor) complex 1 (TORC1) plays a central role in signalling pathways that allow cells to respond to the environment, including nutritional status signalling. TORC1 is widely recognised for its association with various diseases. The budding yeast Saccharomyces cerevisiae has two types of TORC1, Tor1-containing TORC1 and Tor2-containing TORC1, which comprise different constituent proteins but are considered to have the same function. Here, we computationally modelled the relevant complex structures and then, based on the structures, rationally engineered a Tor2 mutant that could form Tor complex 2 (TORC2) but not TORC1, resulting in a redesign of the complex states. Functional analysis of the Tor2 mutant revealed that the two types of TORC1 induce different phenotypes, with changes observed in rapamycin, caffeine and pH dependencies of cell growth, as well as in replicative and chronological lifespan. These findings uncovered by a general approach with huge potential – model structure-based engineering – are expected to provide further insights into various fields such as molecular evolution and lifespan.
Longitudinal Associations between 24-h Movement Behaviors and Cardiometabolic Biomarkers: A Natural Experiment over Retirement
Authors: SUORSA KRISTIN , LESKINEN TUIJA , GUPTA NIDHI , ANDERSEN LARS L. , PASANEN JESSE , HETTIARACHCHI PASAN , JOHANSSON PETER J. , PENTTI JAANA , VAHTERA JUSSI , STENHOLM SARI 
Published: February 2024

ABSTRACT

Introduction
Physical activity, sedentary behavior, and sleep, that is, 24-h movement behaviors, often change in the transition from work to retirement, which may affect cardiometabolic health. This study investigates the longitudinal associations between changes in 24-h movement behaviors and cardiometabolic biomarkers during the retirement transition.

Methods
Retiring public sector workers (n = 212; mean (SD) age, 63.5 (1.1) yr) from the Finnish Retirement and Aging study used a thigh-worn Axivity accelerometer and filled out a diary to obtain data on daily time spent in sedentary behavior (SED), light physical activity (LPA), and moderate-to-vigorous physical activity (MVPA), and sleep before and after retirement (1 yr in-between). Cardiometabolic biomarkers, including LDL-cholesterol, HDL-cholesterol, total/HDL-cholesterol ratio, triglycerides, C-reactive protein, fasting glucose, and insulin, were measured. Associations between changes in 24-h movement behaviors and cardiometabolic biomarkers were analyzed using compositional robust regression and isotemporal substitution analysis.

Results
Increasing LPA in relation to remaining behaviors was associated with an increase in HDL-cholesterol and decrease in total/HDL-cholesterol ratio (P < 0.05 for both). For instance, reallocation of 30 min from sleep/SED to LPA was associated with an increase in HDL-cholesterol by 0.02 mmol·L−1. Moreover, increasing MVPA in relation to remaining behaviors was associated with a decrease in triglycerides (P = 0.02). Reallocation of 30 min from SED/sleep to MVPA was associated with 0.07–0.08 mmol·L−1 decrease in triglycerides. Findings related to LDL-cholesterol, C-reactive protein, fasting glucose, and insulin were less conclusive.

Conclusions
During the transition from work to retirement, increasing physical activity at the expense of passive behaviors was associated with a better lipid profile. Our findings suggest that life transitions like retirement could be utilized more as an optimal time window for promoting physical activity and health.
Association of lipid-lowering drugs with osteoarthritis outcomes from a drug-target Mendelian randomization study
Authors: Ma Weiwei , Chen Honggu , Zhang Zhiwen , Xiong Yong 
Published: February 2024

Background
Osteoarthritis (OA), a prevalent musculoskeletal disorder, has been suggested to have a potential association with metabolic syndrome, particularly lipid metabolism. Studies exploring the effects of lipid-lowering drugs on OA have yielded conflicting results.

Objective
This study employed a drug-targeted Mendelian randomization approach to investigate the association between genetically predicted lipid-modulating effects of commonly targeted lipid-lowering agents and the risk of OA, with the aim of providing a theoretical foundation for the use of lipid-lowering drugs in OA treatment.

Methods
Employing Mendelian randomization (MR) analysis, we examined the potential causal relationship between lipid-lowering drugs and OA. Genetic variants associated with LDL cholesterol levels were selected from the GWAS summary data, and a series of statistical analyses, including inverse-variance weighted (IVW), weighted median (WM), and MR-Egger, were performed to estimate causal effects.

Results
We observed significant associations between genetically proxied lipid-lowering drug targets and OA risk. Notably, HMGCR-mediated LDL cholesterol showed an association with overall OA of the hip or knee (OR = 0.865, 95%CI: 0.762 to 0.983, p = 0.026, q = 0.07) and knee osteoarthritis specifically (OR = 0.746, 95%CI: 0.639 to 0.871, p = 2.180×10−4, q = 0.004). PCSK9-mediated LDL cholesterol also demonstrated an association with OA of the hip or knee (OR = 0.915, 95%CI: 0.847 to 0.988, p = 0.023, q = 0.07) and knee osteoarthritis (OR = 0.901, 95%CI: 0.821 to 0.990, p = 0.03, q = 0.07). NPC1L1-mediated LDL cholesterol showed a positive association with OA of the hip or knee (OR = 1.460, 95%CI: 1.127 to 1.890, p = 0.004, q = 0.033). Furthermore, LDLR-mediated LDL cholesterol demonstrated an association with OA of the hip or knee (OR = 0.882, 95%CI: 0.788 to 0.988, p = 0.03, q = 0.07) and hip osteoarthritis (OR = 0.867, 95%CI: 0.769 to 0.978, p = 0.02, q = 0.07).

Conclusions
These findings provide preliminary evidence for the potential therapeutic use of lipid-lowering drugs in OA treatment. Further investigation is needed to validate these findings and explore the precise mechanisms underlying the observed associations.
Insurance Companies' Poor Adherence to Guidelines for Moderate-to-Severe Ulcerative Colitis/Crohn's Disease Management
Authors: Anderson Kelsey L. , Anand Rajsavi , Feuerstein Joseph D. 
Published: February 2024

INTRODUCTION:
Moderate-to-severe inflammatory bowel disease treatment transitioned from step-up therapy to induction of remission with a biologic agent, but insurance coverage varies.

METHODS:
Top 50 insurance companies were searched for publicly available policies for 5 biologic/small molecule agents. Data regarding coverage requirements were compared with American College of Gastroenterology/American Gastroenterological Association guidelines.

RESULTS:
Thirty-four insurers had public policies. Adherence to American College of Gastroenterology/American Gastroenterological Association guidelines ranged from 5.8% to 58.8%. Only 14.71% and 17.65% of policies permitted any first-line biologic therapy in Crohn's disease and in ulcerative colitis.

DISCUSSION:
Nearly every insurance company required failure of steroids and immunomodulators before biologic therapy. Further work is required to improve patient access to standard-of-care treatment.
A Rare Case of Gastric Extranodal NK/T-Cell Lymphoma With Orbital Involvement
Authors: Zhao Billy , Kim Hyun Jae , Tam Landon , Xiong Wei , Rosenfeld Greg 
Published: February 2024

ABSTRACT
Gastric extranodal NK/T-cell lymphoma (ENKTL) is a rare presentation of a rare disease. We report a 33-year-old woman presenting with epigastric pain, nausea, and vomiting. Endoscopic examination revealed gastric and duodenal ulceration. Biopsy of the ulcers revealed ENKTL. The patient began treatment, but developed hemorrhagic shock from her ulcers and died. Gastric ENKTL is a rare disease that presents with gastric ulceration. It has a high rate of mortality, and treatment is challenging because of its aggressive nature and lack of high-quality data to guide therapy.
Building planar polygon spaces from the projective braid arrangement
Authors: Daundkar Navnath , Deshpande Priyavrat 
Published: February 2024

Abstract
The moduli space of planar polygons with generic side lengths is a smooth, closed manifold.
It is known that these manifolds contain the moduli space of distinct points on the real projective line as an open dense subset.
Kapranov showed that the real points of the Deligne–Mumford–Knudson compactification can be obtained from the projective Coxeter complex of type 𝐴 (equivalently, the projective braid arrangement) by iteratively blowing up along the minimal building set.
In this paper, we show that these planar polygon spaces can also be obtained from the projective Coxeter complex of type 𝐴 by performing an iterative cellular surgery along a subcollection of the minimal building set.
Interestingly, this subcollection is determined by the combinatorial data associated with the length vector called the genetic code.
Potential of multifunctional electrospun nanofibers in cancer management
Authors: AL-Attabi Abduladheem , Abdulhadi Mohanad Ali , Al-Ameer Lubna R. , Hussein Mohammed Dohan Naeem , Abdulameer Sada Jasim , Zabibah Rahman S. , Fadhil Ali A. 
Published: February 2024

Abstract
A controlled and sustained release of drugs is much more desirable and beneficial when dealing with cancer, as such drugs also harm normal cells. Available anticancer drugs used in chemotherapy are associated with severe side effects due to high dosage requirements. Electrospun nanofibers have an extensive surface area, controllable pore size, and tunable drug release profiles, which make these nanofibers promising candidates in the medical field. Electrospun fibrous matrices are increasingly used in cancer research as patches for drug delivery in living organisms and as scaffolds for cancer modeling in the lab. Towards these applications, nanofibers synthesized by electrospinning have exhibited great clinical potential as a biomimetic tumor microenvironment model for drug screening, a controllable platform for localized, prolonged drug release for cancer therapy, and a human cancer diagnostic tool for capture and isolation of circulating tumor cells in the bloodstream and detection of cancer-associated biomarkers. This review briefly describes most of the materials used in electrospinning. Then, we discuss two ways that electrospinning is used to fight cancer: first, as patches with anticancer agents for therapeutic cargo delivery, and second, as three-dimensional fiber for filtering and detecting cancers.
Performance analysis of FSO link under the effect of fog in Delhi region, India
Authors: Kaur Sanmukh 
Published: February 2024

Abstract
Fog attenuation causes more loss than other weather conditions in a free space optics (FSO) link thus limiting the visibility distance. This work presents a detailed survey on the attenuation of the transmitted signal as a result of variation in visibility range caused by different fog conditions of the Delhi, Safdarjung region. Kim and Kruse models have been used to calculate attenuation as a result of fog conditions for three specific months (January, February and December) for seven consecutive years starting from 2013 to 2019. Received signal quality has been analyzed as a function of transmitted power, data rate, transmission range and operation wavelength. Descriptive statistical analysis of real time observed visibility data allows for the estimation of specific optical attenuation and enables in determining the link availability of the region for the complete year.
The crystal structure of poly[di(μ2-aqua)-diaqua-bis(3-aminopyridine-4-carboxylate-κ2
O: O′)-tetra(μ2-3-aminopyridine-4-carboxylate-κ2
O: O′)-dineodymium(III), [Nd2(C6H5N2O2)6(H2O)4]
n
Authors: Pan Xiang-Ping , Ping Zhao-Yan , Zhao Wang , Zheng Qing-Hua 
Published: February 2024

Abstract
[Nd2(C6H5N2O2)6(H2O)4]
n
, monoclinic, P21/c (no. 14), a = 9.383(3) Å, b = 22.741(6) Å, c = 18.775(5) Å, β = 90.231(5)°, V = 4006(2) Å3, Z = 4, Rgt
(F) = 0.0427, wRref
(F
2) = 0.0862, T = 296 K.
Crystal structure of poly[diaqua- (μ4-5-(1H-1,2,4-triazol-1-yl)benzene-1,3-dicarboxylato-κ5N:O,O’:O’’:O’’’)calcium(II), C10H9CaN3O6
Authors: Zhao Xing-Ling , Zhang Qi-Hang , Yang Jian-Feng , Wu Xue-Yuan 
Published: February 2024

Abstract
C10H9CaN3O6, monoclinic, P21/n, a = 9.3441(2) Å, b = 6.6142(2) Å, c = 18.6509(4) Å, β = 92.001(2)°, V = 1151.99(5) Å3, Z = 4, R
gt(F) = 0.0398, wR
ref (F
2) = 0.1101, T = 298 K.