bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical efficacy and safety of composite non‐cross‐linked hyaluronic acid for treating tear trough‐lower eyelid bag deformity
Authors: Zhou Xiaomei , Yi Yan , Liu Zeming , Zhang Qi , Wu Yiping , Luo Xiao 
Published: March 2024

AbstractBackgroundTear trough‐eye bag deformities may appear in young Asian patients due to the weak support of their facial skeletons. For these patients with better periorbital skin elasticity, the injection may be more suitable than surgery for treating tear trough‐lower eyelid bag deformity.AimsIdentify the clinical efficacy and safety of non‐cross‐linked HA in the treatment of tear trough‐lower eyelid bag deformity.MethodsIn this study, we analyzed pre‐ and postinjection photographs of 55 patients treated with non‐cross‐linked hyaluronic acid (HA) for tear trough‐lower eyelid bag deformity.ResultsThe mean [SD] scores of modified Goldberg score suggested that the most significant improvement of preoperative and postoperative scores was in tear trough depression, followed by infraorbital triangular depression, orbital fat prolapse, loss of skin elasticity, and skin transparency. Only transient localized complications were observed, including bruising, swelling, and erythema. There were no serious complications, such as skin necrosis or visual impairment.ConclusionsOur study confirmed the beneficial efficacy and minor complications of composite non‐cross‐linked HA for the treatment of tear trough‐lower eyelid bag deformity.
Current understanding of the pathogenesis of placenta accreta spectrum disorder with focus on mitochondrial function
Authors: Kobayashi Hiroshi , Matsubara Sho , Yoshimoto Chiharu , Shigetomi Hiroshi , Imanaka Shogo 
Published: March 2024

AbstractAimThe refinement of assisted reproductive technology, including the development of cryopreservation techniques (vitrification) and ovarian stimulation protocols, makes frozen embryo transfer (FET) an alternative to fresh ET and has contributed to the success of assisted reproductive technology. Compared with fresh ET cycles, FET cycles were associated with better in vitro fertilization outcomes; however, the occurrence of pregnancy‐induced hypertension, preeclampsia, and placenta accreta spectrum (PAS) was higher in FET cycles. PAS has been increasing steadily in incidence as a life‐threatening condition along with cesarean rates worldwide. In this review, we summarize the current understanding of the pathogenesis of PAS and discuss future research directions.MethodsA literature search was performed in the PubMed and Google Scholar databases.ResultsRisk factors associated with PAS incidence include a primary defect of the decidua basalis or scar dehiscence, aberrant vascular remodeling, and abnormally invasive trophoblasts, or a combination thereof. Freezing, thawing, and hormone replacement manipulations have been shown to affect multiple cellular pathways, including cell proliferation, invasion, epithelial‐to‐mesenchymal transition (EMT), and mitochondrial function. Molecules involved in abnormal migration and EMT of extravillous trophoblast cells are beginning to be identified in PAS placentas. Many of these molecules were also found to be involved in mitochondrial biogenesis and dynamics.ConclusionThe etiology of PAS may be a multifactorial genesis with intrinsic predisposition (e.g., placental abnormalities) and certain environmental factors (e.g., defective decidua) as triggers for its development. A distinctive feature of this review is its focus on the potential factors linking mitochondrial function to PAS development.
The near‐complete genome assembly of Reynoutria multiflora reveals the genetic basis of stilbene and anthraquinone biosynthesis
Authors: He Qiang , Miao Yuqing , Zheng Xinyuan , Wang Yaru , Wang Yitao , Jia Zheng , Zhang Hongyu , Wang Yu , Xiao Yao , Du Cailian , Li Wei , Xing Longsheng , Du Huilong 
Published: March 2024

AbstractReynoutria multiflora is a widely used medicinal plant in China. Its medicinal compounds are mainly stilbenes and anthraquinones which possess important pharmacological activities in anti‐aging, anti‐inflammatory and anti‐oxidation, but their biosynthetic pathways are still largely unresolved. Here, we reported a near‐complete genome assembly of R. multiflora consisting of 1.39 Gb with a contig N50 of 122.91 Mb and only one gap left. Genome evolution analysis revealed that two recent bursts of long terminal repeats (LTRs) contributed significantly to the increased genome size of R. multiflora, and numerous large chromosome rearrangements were observed between R. multiflora and Fagopyrum tataricum genomes. Comparative genomics analysis revealed that a recent whole‐genome duplication specific to Polygonaceae led to a significant expansion of gene families associated with disease tolerance and the biosynthesis of stilbenes and anthraquinones in R. multiflora. Combining transcriptomic and metabolomic analyses, we elucidated the molecular mechanisms underlying the dynamic changes in content of medicinal ingredients in R. multiflora roots across different growth years. Additionally, we identified several putative key genes responsible for anthraquinone and stilbene biosynthesis. We identified a stilbene synthase gene PM0G05131 highly expressed in roost, which may exhibit an important role in the accumulation of stilbenes in R. multiflora. These genomic data will expedite the discovery of anthraquinone and stilbenes biosynthesis pathways in medicinal plants.
Comparative disposition kinetics of oral deracoxib in sheep and goats
Authors: Fadel Charbel , Łebkowska‐Wieruszewska Beata , Lisowski Andrzej , Serih Firas , Poapolathep Amnart , Giorgi Mario 
Published: March 2024

AbstractThis study investigates the pharmacokinetics (PK) of deracoxib (DX), a selective COX‐2 inhibitor, in sheep and goats following a single oral dose. DX, approved for dogs, holds potential as an alternative NSAID in small ruminants, particularly in light of heightened concern regarding abomasal ulceration. The study employed an oral administration of DX at a dose of 150 mg/head (sheep and goats), and plasma concentrations were determined after validating a high‐performance liquid chromatography method, coupled to a UV detector. The PK parameters, including maximum plasma concentration (C
max), time to reach C
max (T
max), elimination half‐life (t
1/2), and area under the curve (AUC), were evaluated through non‐compartmental analysis. Results showed detectable DX in plasma up to 48 h, with no observed adverse effects. No significant differences in any PK parameters were noted between sheep and goats. Notably, t
1/2 values were relatively long, at 16.66 h for sheep and 22.86 h for goats. Despite the fact that both species exhibited comparable drug exposure, high individual variability was noted within each species, suggesting to take into account individual variations in response to DX treatment, rather than species‐specific considerations. Additional research involving pharmacodynamics and multiple‐dose studies is warranted to comprehensively assess the profile of DX in these species.
The predictive value of confusion assessment method‐intensive care unit and intensive care delirium screening checklist for delirium in critically ill patients in the intensive care unit: A systematic review and meta‐analysis
Authors: Diao Yujie , Yu Xiaomin , Zhang Qin , Chen Xiaoli 
Published: March 2024

AbstractBackgroundApproximately 16%–89% of patients developed delirium during hospitalization in the intensive care unit (ICU). Studies on the accuracy and clinical application of ICU delirium screening tools exist, but the results are inconsistent. Moreover, the accuracy of different screening tools varied greatly.AimTo compare the diagnostic accuracy of Confusion Assessment Method‐Intensive Care Unit (CAM‐ICU) and Intensive Care Delirium Screening Checklist (ICDSC) for delirium screening in critically ill patients in the ICU.Study DesignWe searched PubMed, Embase, Cochrane Central Register of Controlled Trials, Medline, and SciELO databases for relevant studies by combining relevant medical subject headings (MeSH) and keywords. Each database was searched from its creation to 30 January 2024. The included literature was screened by title, abstract, and full text. The diagnostic studies were summarized using Stata 14.0 software. SEN, SPE, PLR, NLR, DOR, and 95% confidence interval (CI) of the diagnostic studies were combined, the SROC analysis was performed, and the area under curve was estimated.ResultsThirty‐two articles from the database met the inclusion criteria. The number of studies on CAM‐ICU and ICDSC was 28 and 14, respectively. For CAM‐ICU, the pooled sensitivity and specificity were 0.81 (95% CI: 0.81–0.81) and 0.94 (95% CI: 0.94–0.94), and the hierarchical SROC curve was 0.96 (95% CI: 0.93–0.97). Regarding the ICDSC, The pooled sensitivity and specificity were 0.79 (95% CI: 0.68–0.86) and 0.90 (95% CI: 0.84–0.93), and the hierarchical SROC curve was 0.92 (95% CI: 0.89–0.94). Regarding the likelihood ratio, the CAM‐ICU has a high PLR of 14.24 (95% CI: 14.24–14.24) and a low NLR of 0.20 (95% CI: 0.20–0.20). The ICDSC has a low PLR of 7.64 (95% CI: 5.37–10.87) and a high NLR of 0.24 (95% CI: 0.16–0.35).ConclusionsCAM‐ICU showed good performance in terms of screening and diagnostic efficacies for delirium in critically ill patients. In view of the diagnostic accuracy of these two tools in delirium assessment, the strategies on how to increase their implementation in delirium screening among ICU patients are the focus of future research.Relevance for Clinical PracticeCAM‐ICU is recommended as the first choice to evaluate delirium in clinical practice, followed by ICDSC. Future studies can explore the predictive value of CAM‐ICU and ICDSC in different special populations and different types of delirium.
Roadmap for the next decade of plant programmed cell death research
Authors: Kacprzyk Joanna , Burke Rory , Armengot Laia , Coppola Marianna , Tattrie Sophie B. , Vahldick Hannah , Bassham Diane C. , Bosch Maurice , Brereton Nicholas J. B. , Cacas Jean‐Luc , Coll Núria S. , Gallois Patrick , Kuchitsu Kazuyuki , Nowack Moritz K. , Rogers Hilary J. , Van Breusegem Frank , Gunawardena Arunika H. L. A. N. , McCabe Paul F. 
Published: March 2024

SummaryProgrammed cell death (PCD) is fundamentally important for plant development, abiotic stress responses and immunity, but our understanding of its regulation remains fragmented. Building a stronger research community is required to accelerate progress in this area through knowledge exchange and constructive debate. In this Viewpoint, we aim to initiate a collective effort to integrate data across a diverse set of experimental models to facilitate characterisation of the fundamental mechanisms underlying plant PCD and ultimately aid the development of a new plant cell death classification system in the future. We also put forward our vision for the next decade of plant PCD research stemming from discussions held during the 31st New Phytologist workshop, ‘The Life and Death Decisions of Plant Cells’ that took place at University College Dublin in Ireland (14–15 June 2023). We convey the key areas of significant progress and possible future research directions identified, including resolving the spatiotemporal control of cell death, isolation of its molecular and genetic regulators, and harnessing technical advances for studying PCD events in plants. Further, we review the breadth of potential impacts of plant PCD research and highlight the promising new applications of findings from this dynamically evolving field.
End‐of‐day assessment of asymptomatic versus highly symptomatic soft contact lens wearers
Authors: Maldonado‐Codina Carole , Navascues‐Cornago Maria , Smith Sarah L. , Read Michael L. , Lakkis Carol , Morgan Philip B. 
Published: March 2024

AbstractPurposeTo investigate differences in key clinical parameters between asymptomatic and highly symptomatic soft contact lens (CL) wearers after 14 h of wear.MethodsIn this pilot investigation, Phase 1 identified asymptomatic (CLDEQ‐8 score ≤ 7) and highly symptomatic (CLDEQ‐8 score ≥ 20) subjects after fitting with nelfilcon A CLs. Phase 2 investigated the following over a single nelfilcon A CL‐wearing day (14 ± 2 h): blinking characteristics, tear meniscus height (TMH), non‐invasive tear break‐up time (NIBUT), tear film osmolarity and eyelid margin staining. Parameters for the two groups were compared using linear mixed models and post‐hoc testing. The relationship between comfort scores and the clinical parameters was also investigated.ResultsOverall, 161 and 42 subjects were enrolled into Phase 1 and 2, respectively. Twenty‐five asymptomatic and 17 symptomatic subjects completed Phase 2. Lower eyelid TMH was decreased after 14 h in symptomatic compared with asymptomatic subjects (least square mean [LSM] difference −0.04 mm, 95% CI: −0.07, −0.01). Osmolarity was lower in symptomatic than in asymptomatic subjects at fitting (LSM difference −9.89, 95% CI: −18.91, −0.86). Upper eyelid margin staining was greater after 14 h in symptomatic than in asymptomatic subjects (LSM difference 0.53, 95% CI: 0.01, 1.05) and greater after 14 h than baseline in the symptomatic group (LSM difference 0.61, 95% CI: 0.16, 1.07). There was a significant relationship between comfort and upper eyelid margin staining (r = −0.40, 95% CI: −0.63, −0.11) and blink rate (r = −0.31, 95% CI: −0.57, −0.003).ConclusionThe potential parameters most effective in differentiating asymptomatic from symptomatic wearers were upper eyelid margin staining and lower TMH. The parameter with the strongest relationship to comfort was upper eyelid margin staining, where higher comfort scores were associated with lower levels of staining.
Patient positioning and its impact on perioperative outcomes in children: A narrative review
Authors: Patterson Heather , Eady Jonathan , Sommerfield Aine , Sommerfield David , Hauser Neil , von Ungern‐Sternberg Britta S. 
Published: March 2024

AbstractPatient positioning interacts with a number of body systems and can impact clinically important perioperative outcomes. In this educational review, we present the available evidence on the impact that patient positioning can have in the pediatric perioperative setting. A literature search was conducted using search terms that focused on pediatric perioperative outcomes prioritized by contemporary research in this area. Several key themes were identified: the effects of positioning on respiratory outcomes, cardiovascular outcomes, enteral function, patient and carer‐centered outcomes, and soft issue injuries. We encountered considerable heterogeneity in research in this area. There may be a role for lateral positioning to reduce respiratory adverse outcomes, head elevation for intubation and improved oxygenation, and upright positioning to reduce peri‐procedural anxiety.
Accuracy of cone‐beam computed tomography in imaging the components of the periodontal phenotype
Authors: Schulze Ralf , Couso‐Queiruga Emilio , Katsaros Christos 
Published: March 2024

AbstractThe components and dimensions of the periodontal and peri‐implant phenotype have a high relevance in contemporary dental research and should be taken into consideration in the decision‐making process in the management of a variety of clinical scenarios to optimize the outcomes of therapy. Various assessment methods for quantifying and classifying the phenotypical dimensions have emerged and developed in recent decades. Nevertheless, the use of cone‐beam computed tomography (CBCT) scans remains the most commonly used approach worldwide. However, the accuracy to adequately imaging and measuring the dimensions of the hard and soft tissue components around teeth may represent a significant challenge in different clinical scenarios due to factors such as the age of the patient and motion during the scan, presence of metallic artifacts causing streaks and gray‐value distortion, overlapping of soft tissue structures, machine performance, file processing, and small voxel size among others. These factors pose a particular challenge when tiny structures are under investigation, for example, the buccal/lingual bony or soft tissue layer of lower/upper incisors. Therefore, this review addresses the underlying technical information of the use of CBCT scans, and suggests some recommendations on the utilization of this method of assessment to optimally use it despite its' system‐inherent limitations.
The effects of a combined physical activity and health education program on health knowledge and well‐being of socially vulnerable children
Authors: Møller Trine K. , Larsen Malte N. , Pfeffer Kristina , Frydenlund Sabrina Egelund , Ntoumanis Nikos , Krustrup Peter 
Published: March 2024

AbstractThe purpose of the present study was to evaluate the effects of the football‐based health education program “11 for Health” on health knowledge and well‐being in the setting of a 10‐week residential stay in a Danish charity home for socially vulnerable children. Six hundred and fourteen children participated in the study, of which 305 took part in the standard program plus “11 for Health” (SG+: 12.4 ± 1.4 (mean ± SD) years) and 309 took part in the standard program (SG: 12.4 ± 1.6 years). We used a crossover design over two full years. The study examined changes in health knowledge and well‐being through questionnaires. Overall health knowledge increased more in SG+ than SG over 10 weeks (6.6 vs. 3.4%, p < 0.05). The overall well‐being scores were markedly improved (p < 0.05) by 4.54 ± 7.17 AU in SG+ and 4.51 ± 7.16 AU in SG, with no between‐group differences. Specific improvements (p < 0.05) were seen in all well‐being subcategories, raising the well‐being scores to the national average. In conclusion, a 10‐week stay at a Danish charity home, the Christmas Seal Home, markedly affected health knowledge and well‐being of socially vulnerable children. When the football‐based health education program—11 for Health—was added, there were additional positive effects on health knowledge.
Effect of repeated prolonged exercise on liver fat content and visceral adipose tissue in well‐trained older men
Authors: Poggi Axel Illeris , Andreasen Martin Winther , Sahl Ronni Eg , Hansen Mikkel Thunestvedt , Rømer Tue , Frandsen Jacob , Linden Frederik Hvid , Høgh‐Schmidt Erik , Boesen Mikael Ploug , Ostrowski Sisse Rye , Larsen Steen , Dela Flemming , Helge Jørn Wulff 
Published: March 2024

AbstractIntroductionLiver fat (LF) and visceral adipose tissue (VAT) content decreases with training, however, this has mainly been investigated in sedentary obese or healthy participants. The aim of this study was to investigate the effects of repeated prolonged exercise on LF and VAT content in well‐trained older men and to compare baseline LF and VAT content to recreationally active older men.MethodA group of five well‐trained older men were tested before and after cycling a total distance of 2558 km in 16 consecutive days. VAT content and body composition was measured using DXA before a bicycle ergometer test was performed to determine maximal fat oxidation (MFO), maximal oxygen consumption (), and the relative intensity at which MFO occurred (Fatmax). LF content was measured on a separate day using MRI. For comparison of baseline values, a control group of eight healthy age‐ and BMI‐matched recreationally active men were recruited.ResultsThe well‐trained older men had lower VAT (p = 0.02), and a tendency toward lower LF content (p = 0.06) compared with the control group. The intervention resulted in decreased LF content (p = 0.02), but VAT, fat mass, and lean mass remained unchanged. , MFO, and Fatmax were not affected by the intervention.ConclusionThe study found that repeated prolonged exercise reduced LF content, but VAT and remained unchanged. Aerobic capacity was aligned with lower LF and VAT in older active men.
Starting and sustaining fruitful collaborations in psychology
Authors: Park Lora E. , Aknin Lara B. , Gaither Sarah E. , Impett Emily A. , Whillans Ashley V. 
Published: March 2024

AbstractMuch of psychological science relies on collaboration—from generating new theories and study ideas, to collecting and analyzing data, to writing and sharing results with the broader community. Learning how to collaborate with others is an important skill, yet this process is not often explicitly discussed in academia. Here, five researchers from diverse backgrounds share their experiences and advice on starting and sustaining collaborations. In doing so, they reflect on aspects of both successful (and failed) collaborations with students, colleagues within and outside of psychology, and members of industry and organizational partners beyond academia. Recommendations and challenges of productive collaborations are discussed, along with examples of how collaborative teams can contribute to psychological science, address real‐world issues, and make the process of conducting research more enjoyable and rewarding.
Individual differences in interpersonal emotion regulation: What makes some people more (or less) successful than others?
Authors: Niven Karen , Hughes David J. , Tan J. Keane , Wickett Robin 
Published: March 2024

AbstractPeople vary in the effectiveness with which they can change the way that others feel, yet we know surprisingly little about what drives these individual differences in interpersonal emotion regulation success. This paper provides a framework for describing ‘success’ in interpersonal emotion regulation and synthesizes extant theory and research regarding how personality and cognitive ability relate to interpersonal emotion regulation success. In doing so, our review brings together work from several related fields to offer an integrative framework to generate and guide future research that aims to understand why some people are proficient at influencing the emotions of others and why some are not, often suffering additional unintended consequences, such as diminished work or relationship success.
Leveraging deep neural networks to uncover unprecedented levels of precision in the diagnosis of hair and scalp disorders
Authors: Chowdhury Mohammad Sayem , Sultan Tofayet , Jahan Nusrat , Mridha Muhammad Firoz , Safran Mejdl , Alfarhood Sultan , Che Dunren 
Published: March 2024

AbstractBackgroundHair and scalp disorders present a significant challenge in dermatology due to their clinical diversity and overlapping symptoms, often leading to misdiagnoses. Traditional diagnostic methods rely heavily on clinical expertise and are limited by subjectivity and accessibility, necessitating more advanced and accessible diagnostic tools. Artificial intelligence (AI) and deep learning offer a promising solution for more accurate and efficient diagnosis.MethodsThe research employs a modified Xception model incorporating ReLU activation, dense layers, global average pooling, regularization and dropout layers. This deep learning approach is evaluated against existing models like VGG19, Inception, ResNet, and DenseNet for its efficacy in accurately diagnosing various hair and scalp disorders.ResultsThe model achieved a 92% accuracy rate, significantly outperforming the comparative models, with accuracies ranging from 50% to 80%. Explainable AI techniques like Gradient‐weighted Class Activation Mapping (Grad‐CAM) and Saliency Map provided deeper insights into the model's decision‐making process.ConclusionThis study emphasizes the potential of AI in dermatology, particularly in accurately diagnosing hair and scalp disorders. The superior accuracy and interpretability of the model represents a significant advancement in dermatological diagnostics, promising more reliable and accessible diagnostic methods.