bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Coach and Six: Chapbook Residue in Late Eighteenth-Century Children’s Literature
Authors: O'Malley Andrew 
Published: February 2024

<p> [para. 1]: "The predominantly didactic form of the children's book characteristic of the rational and evangelical writing movements of the late eighteenth century did not, of course, appear on the market fully formed. Predating, and, indeed, eventually coexisting with, the rational diversions and evangelical children's books by such authors as Maria Edgeworth, Thomas Day, Sarah Trimmer, and Dorothy Kilner that flooded the English market in the last two decades of the eighteenth century were scores of what I have dubbed "transitional" or "hybrid" books. These books, while acknowledging the trend toward inculcating middle-class values and ideology in young readers, still clung to earlier chapbook forms and themes. The survival of such chapbook elements in a middle-class pedagogical environment that was growing increasingly hostile to plebeian influences raises issues of class relations and the cultural production of class. To demonstrate the ubiquity of these transitional books in the late eighteenth century, this article will survey not only such well-known early children's books as <em>A Little Pretty Pocket Book</em> (1744), and <em>The History of Little Goody Two-Shoes</em> (1766), but also such works as <em>The Friends; or the History of Billy Freeman and Tommy Truelove</em> (c. 1787), and <em>Nurse Dandlem's Little Repository of Great Instruction</em> (c. 1784), which have received little or no critical attention."</p>
LITERARY REPRESENTATION OF THE MEMORY OF WAR IN THE SHORT PROSE BY OLES HONCHAR
Authors: Приліпко Ірина 
Published: February 2024

The paper examines the specifics of the literary expression of war memories in small epic forms by O. Honchar. The literary representation of the wartime past determines the actualization of autobiographical factors and deepens the psychologization of the image. It also shapes the peculiarities of the time-space and narrative organization of the works.
Referring to the past causes modifications of the chronotope: the war is integrated into the present of the author and his interlocutors. It appears through the prism of the perception of participants and eyewitnesses, seemingly relived here and now. The representation of the past in new temporal coordinates determines its understanding from the distance of time and reinterpretation of the experience on the worldview and philosophical plane. The traumatic impact of war in the stories of O. Honchar is most often revealed through moral and ethical issues, such as the behavior and choice of a person in a borderline situation. Therefore, in the space of memories of the war, which are always alive and relevant for the author and his heroes, the theme “man and war” plays a key role. The problem of preserving moral and ethical values in the extreme conditions of war (“From Those Nights,” “March Mud,” “Always Soldiers”) is closely related to issues of individual self-realization, choice, and sacrifice (“Ode to the House in the Snow,” “Woman in Gray,” “Bondarivna”). In the stories by O. Honchar, the memory of the war is represented in various forms of the heroes’ reminiscences of their experiences, embodied in specific, generalized images (breadcrumbs, March mud, place of arms).
The individual and collective memories of the war take shape as heroes verbalize their wartime past. This process helps them to overcome the trauma. As the heroes-narrators of Honchar’s stories return through memories to the space-time of the war, they relive the traumas of the past, consciously or subconsciously attempting to release and, consequently, overcome them.
ANALISIS PORTOFOLIO OPTIMUM MENGGUNAKAN METODE SIMULASI MONTE CARLO PADA SEPULUH SAHAM LQ45 TERBAIK DI INDONESIA
Authors: Herlisa  , Arman  , Saidi La Ode , La Gubu  , Jufra  , Ruslan  
Published: February 2024

Pada penelitian ini bertujuan untuk mengetahui hasil analisis risiko dan penerapan portofolio optimum menggunakan Metode Simulasi Monte Carlo pada sepuluh saham LQ45 terbaik di Indonesia. Objek pada penelitian ini adalah sepuluh saham LQ45 periode Februari-Juli 2021. Peneliti tertarik mengambil penelitian ini karena ingin mengembangkan kembali penelitian sebelumnya dan menyelesaikan permasalahan yang ada misalnya investor kesulitan dalam memilih portofolio optimum yang nantinya akan dilakukan investasi dan meminimalisir risiko yang ada. Hasil penelitian menunjukkan dari penerapan portofolio optimum menggunakan Metode Simulasi Monte Carlo pada sepuluh saham LQ45 terbaik di Indonesia pada periode Februari-Juli 2021 terletak pada saham UNVR sebesar 90%, saham BCA sebesar 77,99%, saham JSMR sebesar 32,53%, saham PGAS sebesar 30,77%, saham BRI sebesar 28,62%, dan saham ASII sebesar 10,29%. Hasil analisis menunjukkan dari sepuluh saham ada 6 saham yang dijadikan sebagai portofolio optimum dan ada 4 saham dengan bobot portofolio yang lebih rendah adalah saham BNI sebesar 10,07%, saham ACES sebesar 7,69%, saham MDKA sebesar 2,01%, dan saham ANTM sebesar 1,03%. Hal ini disebabkan adanya efek diversifikasi antara saham sehingga dapat menurunkan risiko. Efek diversifikasi akan semakin bernilai besar jika korelasi antara saham rendah.
PERHITUNGAN PREMI MENGGUNAKAN METODE ACCRUED BENEFIT COST PADA ASURANSI DANA PENSIUN BERDASARKAN TABEL MORTALITAS (Studi Kasus: Pegawai Negeri Sipil (PNS) Tahun 2021 Berdasarkan PP No 15 Tahun 2019)
Authors: Sarina  , La Ode Saidi  , Aswani  , Somayasa Wayan , Cahyono Edi , La Gubu  
Published: February 2024

Tujuan dari penelitian ini adalah untuk mengetahui perhitungan dana pensiun dengan mempertimbangkan aspek suku bunga menggunakan metode accrued benefit cost dan besar biaya tambahan yang akan dibayarkan kepada penerima dana pensiun menggunakan metode accrued benefit cost. Metode accrued benefit cost adalah iuran yang umumnya lebih rendah dibandingkan dengan metode lainnya, dan hutangnya akan konsisten dengan target pengembangan manfaat karena kenaikan gaji yang digunakan dalam perhitungan biaya pensiun adalah sesuai dengan realisasinya. Hasil yang diperoleh pada perhitungan premi menggunakan metode accrued benefit cost yaitu berdasarkan usia masuk kerja (PNS) tahun, suku bunga (i) sebesar dengan masa kerja tahun pada tabel mortalitas Indonesia untuk laki-laki. Pegawai wajib membayarkan iuran (premi) pada usia tahun menggunakan metode accrued benefit cost. Besarnya iuran normal terus meningkat seiring dengan bertambahnya usia pegawai. Sedangkan untuk perhitungan besar biaya tambahan dengan menggunakan metode accrued benefit cost diperoleh nilai sebesar Rp. per tahun berdasarkan pengolahan data yang telah dilakukan, diperoleh besar manfaat pensiun selama tahun adalah Rp. . sehingga dengan besar biaya tambahan yang diperoleh yaitu Rp. Rp dapat menutupi kekurangan besar manfaat pensiun yang diperoleh oleh peserta dana pensiun yang dapat digunakan untuk kekurangan defisit.
Synchronized measurement method for urban distribution networks based on proportional-integral control
Authors: Yin Xiaodong , Yu Jicheng , Liang Siyuan , Liu Junjie , Wang Jian , Liu Cheng , Ding Wangwang 
Published: February 2024

In the context of the rising prevalence of renewable energy, the need for precise and synchronized measurements in urban distribution networks has become increasingly critical. Conventional synchronization techniques, which predominantly depend on Global Navigation Satellite System (GNSS) timing signals, are often plagued by significant sampling time errors. Addressing this challenge, this study introduces an innovative automatic synchronization measurement method employing proportional-integral (PI) control. This method is composed of three integral components: the monitoring of local clock phases via pulses per second (PPS) signals, modulation of the clock phase through a PI controller, and the estimation of grid phasors from the synchronized sampled data. The test results of this method on a hardware platform demonstrate its capability to significantly reduce the sampling error from 2 × 10−3 V to an impressive 1 × 10−5 V, while also meeting the requirements of the synchronized phasor measurement standards outlined in C37.118.1. These advancements underscore the significant potential of PI-controlled simultaneous sampling in enhancing the operational efficiency and reliability of urban distribution networks, particularly in environments with a high integration of renewable energy sources.
Inflammatory bowel disease activity threatens ankylosing spondylitis: implications from Mendelian randomization combined with transcriptome analysis
Authors: Ding Yimei , Chen Jiaxu , Li Rouxin , Xue Luan 
Published: February 2024

BackgroundInflammatory bowel disease (IBD) and ankylosing spondylitis (AS) share common traits of chronic recurrent inflammation affecting both the intestines and joints. Epidemiological studies have revealed that the incidence of AS has jumped from 0.3% to 3% among patients with IBD. However, these findings do not definitively establish a causal relationship whereby IBD directly leads to the development of AS. Moreover, whether the activity of IBD will have an impact on this process remains a pending question.MethodsTwo-sample Mendelian randomization (MR) analyses were employed across multiple datasets to investigate the potential of IBD as a risk factor for AS. The pathogenic genes of AS were identified by MR analysis of expression quantitative trait locus. Risk scores for active and inactive patients were calculated by single-sample gene set enrichment analysis. Comparative assessments encompassing alterations in risk transcription factor activity, shifts in signaling pathways, and variances in immune cell profiles were conducted between active and inactive patients. Moreover, the correlation of immune cells and risk genes was quantified.ResultsA total of 6 MR analyses, conducted across 3 exposure datasets and 2 outcome datasets, consistently revealed that IBD substantially elevates the risk of AS development. The MR analysis of the two outcome datasets identified 66 and 54 risk genes, respectively. Notably, both the risk scores computed from the two distinct sets of risk genes were notably higher in active patients compared to their inactive counterparts. Discernible variations in the activity of risk-associated transcription factors were observed between active and inactive patients. In addition, three inflammatory pathways exhibited marked activation in active patients. Moreover, seven specific immune cell types, closely linked to disease activity, exhibited statistically significant correlations with the identified risk genes.ConclusionBy combining Mendelian randomization with transcriptome analysis, this study postulates IBD as a significant risk factor for AS, and further presents innovative evidence for the impact of IBD activity on the progression of AS.
Clinical features and prognosis of systemic lupus erythematosus complicated by active cytomegalovirus infection: a retrospective cohort study
Authors: Chen Yan , Zhang Lifan , Liu Yuchen , Liu Ye , Zhao Lidan , Zhou Baotong , Ruan Guiren , Shi Xiaochun , Liu Xiaoqing 
Published: February 2024

ObjectiveThe aim of this study was to investigate the clinical traits and consequences of systemic lupus erythematosus (SLE) complicated by active cytomegalovirus (CMV) infection.MethodsThis retrospective review involved the examination of medical records for patients diagnosed with SLE who had an active CMV infection at the time of their discharge from Peking Union Medical College Hospital between June 2016 and December 2022. The consistency between plasma CMV deoxyribonucleic acid (DNA) viral load and pp65 antigenemia was analyzed using the chi-square test. Related factors for CMV disease in SLE complicated by active CMV infection patients were analyzed by univariate analysis and multivariable stepwise logistic regression. Cox hazards regression analysis was used to determine predictors for all-cause mortality and CMV recurrence within 3 months.ResultsA total of 206 patients were enrolled in this study. Of the 123 patients who were detected with both plasma CMV DNA viral load and pp65 antigenemia within an interval not exceeding 72 h, the consistency between plasma CMV DNA viral load and pp65 antigenemia was not good (Kappa = −0.304, p &lt; 0.001). Plasma CMV DNA viral load ≥ 1,600 copies/mL [odds ratio (OR) 4.411, 95% CI 1.871–10.402, p = 0.001], current glucocorticoids dose (equivalent to prednisolone) ≥60 mg/d (OR 2.155, 95% CI 1.071–4.334, p = 0.031), and elevated alanine transaminase (OR 3.409, 95% CI 1.563–7.435, p = 0.002) were significant clinical clues indicating CMV disease in SLE. Multivariable Cox hazards regression analysis showed that CMV organ involvement [hazard ratio (HR) 47.222, 95% CI 5.621–396.689, p &lt; 0.001], SLE multi-system involvement (HR 1.794, 95% CI 1.029–3.128, p = 0.039), and elevated hypersensitive C-reactive protein (hsCRP) (HR 5.767, 95% CI 1.190–27.943, p = 0.030) were independent risk factors for 3-month all-cause mortality. CMV organ involvement (HR 3.404, 95% CI 1.074–10.793, p = 0.037) was an independent risk factor for CMV recurrence within 3 months.ConclusionIn SLE patients, plasma CMV DNA viral load seemed to have a higher value in the diagnosis of CMV disease; patients with CMV organ involvement, SLE multi-system involvement, and elevated hsCRP might have a higher risk of 3-month all-cause mortality; and patients with CMV organ involvement might have a higher risk of CMV recurrence within 3 months.
Case report: Two pediatric cases of long-term leukemia-free survival with relapsed acute T-lymphoblastic leukemia treated with donor CD7 CAR-T cells bridging to haploidentical stem cell transplantation
Authors: Song Yanzhi , Liu Zhanxiang , Wang Qi , Gao Kong , Wu Tong 
Published: February 2024

IntroductionPatients with relapsed/refractory (r/r) acute T-lymphoblastic leukemia (T-ALL) have a poor prognosis. We developed donor CD7 chimeric antigen receptor T (CAR-T) cells to salvage r/r T-ALL patients and obtained encouraging results. Patients who had not received allogeneic (allo-) hematopoietic stem cell transplantation (HSCT) before CAR-T therapy would develop pancytopenia and immunodeficiency for a long period after CD7 CAR-T therapy; therefore, allo-HSCT is needed in these patients. Here, we report two pediatric r/r T-ALL patients who received donor CD7 CAR-T bridging to allo-HSCT with leukemia-free survival (LFS) and sustained negative minimal residual disease for &gt;2 years.Case presentationPatient 1 was a 10-year-old boy who visited our hospital because of a T-ALL relapse with multiple lymphadenopathies without discomfort. The patient did not achieve remission after one course of induction chemotherapy. The patient then received donor (his father) CD7 CAR-T cells and achieved complete remission (CR). Thirty days after the first CAR-T cell infusion, he received allo-HSCT, and his father was also the donor. His LFS was &gt;3 years. Patient 2 was an 8-year-old boy who was admitted to our hospital with relapsed T-ALL with fever, cough, and mild dyspnea. He did not achieve remission after one course of induction chemotherapy; therefore, he received donor (his father) CD7 CAR-T cells and achieved CR. Twenty-six days after CAR-T cell infusion, the patient received allo-HSCT, with his father as the donor. He has survived for &gt;2 years free of leukemia. At the last follow up, both patients were alive and presented a good quality of lifeConclusionThe long-term survival of these two patients supports the use of CD7 CAR-T therapy bridging to allo–HSCT as an effective and safe treatment with the capacity to make r/r T-ALL a curable disease, similar to r/r acute B-lymphoblastic leukemia.
Machine learning and experimental validation identified autophagy signature in hepatic fibrosis
Authors: Huang Yushen , Luo Wen , Yang Zhijie , Lan Tian , Wei Xiaomou , Wu Hongwen 
Published: February 2024

BackgroundThe molecular mechanisms of hepatic fibrosis (HF), closely related to autophagy, remain unclear. This study aimed to investigate autophagy characteristics in HF.MethodsGene expression profiles (GSE6764, GSE49541 and GSE84044) were downloaded, normalized, and merged. Autophagy-related differentially expressed genes (ARDEGs) were determined using the limma R package and the Wilcoxon rank sum test and then analyzed by GO, KEGG, GSEA and GSVA. The infiltration of immune cells, molecular subtypes and immune types of healthy control (HC) and HF were analyzed. Machine learning was carried out with two methods, by which, core genes were obtained. Models of liver fibrosis in vivo and in vitro were constructed to verify the expression of core genes and corresponding immune cells.ResultsA total of 69 ARDEGs were identified. Series functional cluster analysis showed that ARDEGs were significantly enriched in autophagy and immunity. Activated CD4 T cells, CD56bright natural killer cells, CD56dim natural killer cells, eosinophils, macrophages, mast cells, neutrophils, and type 17 T helper (Th17) cells showed significant differences in infiltration between HC and HF groups. Among ARDEGs, three core genes were identified, that were ATG5, RB1CC1, and PARK2. Considerable changes in the infiltration of immune cells were observed at different expression levels of the three core genes, among which the expression of RB1CC1 was significantly associated with the infiltration of macrophage, Th17 cell, natural killer cell and CD56dim natural killer cell. In the mouse liver fibrosis experiment, ATG5, RB1CC1, and PARK2 were at higher levels in HF group than those in HC group. Compared with HC group, HF group showed low positive area in F4/80, IL-17 and CD56, indicating decreased expression of macrophage, Th17 cell, natural killer cell and CD56dim natural killer cell. Meanwhile, knocking down RB1CC1 was found to inhibit the activation of hepatic stellate cells and alleviate liver fibrosis.ConclusionATG5, RB1CC1, and PARK2 are promising autophagy-related therapeutic biomarkers for HF. This is the first study to identify RB1CC1 in HF, which may promote the progression of liver fibrosis by regulating macrophage, Th17 cell, natural killer cell and CD56dim natural killer cell.
Online pain neuroscience education and graded exposure to movement in breast cancer survivors: protocol of a randomized controlled trial
Authors: Martínez-Miranda Patricia , Casuso-Holgado María Jesús , García-Muñoz Cristina , Muñoz-Fernández María Jesús , Jiménez-Rejano José Jesús 
Published: February 2024

IntroductionCancer-related chronic pain is an important sequelae that damages the quality of life of breast cancer survivors. Pain neuroscience education and graded exposure to movement are therapeutic tools that have been shown to be effective in the management of chronic pain in other populations. However, there are no previous studies that combine them after breast cancer.ObjectiveTo evaluate the effectiveness of an online physiotherapy focused-person program which combines pain neuroscience education and graded exposure to movement for quality of life improvement in breast cancer survivors.MethodologyThis protocol is a randomized controlled trial with a sample size of 40 breast cancer survivors with pain in the last 6 months. Participants will be allocated to the experimental or control group using a fixed size block randomization method. The evaluator and statistician will be blinded to participant allocation. Participants in the experimental group will receive a 12-week intervention based on pain neuroscience education and therapeutic yoga as a graded exposure to movement exercise; participants in the control group will continue with their usual cancer-related symptoms care. Both groups will receive an education booklet. The main outcome will be quality of life, measured by the Functional Assessment of Cancer Therapy – Breast (FACT–B+4); secondary, four outcomes related to pain experience (catastrophising, self-efficacy, kinesiophobia and fear-avoidance behaviors) will be also assessed. All variables will be assessed by two blinded evaluators at four timepoints. A mixed-model analyses of variance ANOVA (2 × 4) will be used to study the effects of the treatment on the dependent variables. All statistical tests will be performed considering a confidence interval of 95%. SPSS program will be used for the data analysis.DiscussionThis research is expected to contribute to breast cancer rehabilitation field. The proposed intervention is also expected to improve self-care skills related to chronic pain and to empower women regarding the management of their symptoms and quality of life.Clinical trial registration:https://clinicaltrials.gov/, NCT04965909.
Contrast-enhanced ultrasound for the preoperative prediction of pathological characteristics in breast cancer
Authors: Li Ling-Ling , Su Quan-Li , Deng Yun-Xia , Guo Wen-Wen , Lun Hai-Mei , Hu Qiao 
Published: February 2024

ObjectiveWe aimed to investigate the value of contrast-enhanced ultrasound (CEUS) in the preoperative prediction of the histological grades and molecular subtypes of breast cancer.MethodsA total of 183 patients with pathologically confirmed breast cancer were included. Contrast enhancement patterns and quantitative parameters were compared in different groups. The receiver operating characteristic (ROC) curve was used to analyze the efficacy of CEUS in the preoperative prediction of pathological characteristics, including histologic grade and molecular subtypes.ResultsHeterogeneous enhancement, perfusion defects, and peripheral radial vessels were mostly observed in higher histologic grade (grade III) breast cancer. Heterogeneous enhancement and perfusion defect were the most effective indicators for grade III breast cancer, with the areas under the ROC curve of 0.768 and 0.756, respectively. There were significant differences in the enhancement intensity, post-enhanced margin, perfusion defects, and peripheral radial vessel among the different molecular subtypes of breast cancer (all P &lt; 0.01). Perfusion defects and clear edge after enhancement were the best qualitative criteria for the diagnosis of HER-2 overexpressed and triple-negative breast cancers, and the corresponding areas under the ROC curves were 0.804 and 0.905, respectively. There were significant differences in PE, WiR, WiPI, and WiWoAUC between grade III vs grade I and II breast cancer (P &lt; 0.05). PE, WiR, WiPI, and WiWoAUC had good efficiency in the diagnosis of high-histologic-grade breast cancer. PE had the highest diagnostic efficiency in Luminal A, while WiPI had the highest diagnostic efficiency in Luminal B subtype breast cancer, and the areas under the ROC curve were 0.825 and 0.838, respectively. WiWoAUC and WiR were the most accurate parameters for assessing triple-negative subtype breast cancers, and the areas under the curve were 0.932 and 0.922, respectively.ConclusionQualitative and quantitative perfusion analysis of contrast-enhanced ultrasound may be useful in the non-invasive prediction of the histological grade and molecular subtypes of breast cancers.