bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of desipramine and citalopram treatments for depression in Parkinson's disease: A double‐blind, randomized, placebo‐controlled study
Authors: Devos David , Dujardin Kathy , Poirot Isabelle , Moreau Caroline , Cottencin Olivier , Thomas Pierre , Destée Alain , Bordet Regis , Defebvre Luc 
Published: March 2008

AbstractDepression is one of the most common psychiatric disturbances in Parkinson's disease (PD). Recent reviews have highlighted the lack of controlled trials and the ensuing difficulty in formulating recommendations for antidepressant use in PD. We sought to establish whether antidepressants provide real benefits and whether tricyclic and selective serotonin reuptake inhibitor (SSRI) antidepressants differ in their short‐term efficacy, because the time to onset of therapeutic benefit remains an important criterion in depression. The short‐term efficacy (after 14 and 30 days) of two antidepressants (desipramine, a predominantly noradrenergic reuptake inhibitor tricyclic and citalopram, a SSRI) was assessed in a double‐blind, randomized, placebo‐ controlled study of 48 nondemented PD patients suffering from major depression. After 14 days, desipramine prompted an improvement in the Montgomery Asberg Depression Rating Scale (MADRS) score, compared with citalopram and placebo. Both antidepressants produced significant improvements in the MADRS score after 30 days. Mild adverse events were twice as frequent in the desipramine group as in the other groups. A predominantly noradrenergic tricyclic antidepressant induced a more intense short‐term effect on parkinsonian depression than did an SSRI. However, desipramine's lower tolerability may outweigh its slight short‐term clinical advantage. © 2008 Movement Disorder Society
Effect of short and long term STN stimulation periods on parkinsonian signs
Authors: Sturman Molly M. , Vaillancourt David E. , Shapiro Mark B. , Metman Leo Verhagen , Bakay Roy A.E. , Corcos Daniel M. 
Published: March 2008

AbstractCurrently, no study of subthalamic nucleus (STN) stimulation has compared continuous stimulation with a period of short‐term stimulation, which is frequently employed in the clinic and in research studies. Therefore, this study examined the effects of STN stimulation over 90 min (short) and greater than 3 months (long) on the cardinal signs of Parkinson's disease. The 90 min time period immediately followed a 12 hour withdrawal from both STN stimulation and medication. Ten PD patients who received STN stimulation were studied. Bradykinesia, rigidity, and tremor were evaluated using the UPDRS and motor control measures which included peak velocity (bradykinesia), work (rigidity), and amplitude (tremor). Results showed no difference between 90 min and greater than 3 months of STN stimulation for the UPDRS or motor control measures. This finding confirms that the treatment efficacy that is derived from a relatively short time course of stimulation generalizes to longer time periods of high frequency STN stimulation that patients experience in their daily lives. As such, it is reasonable to evaluate the effect of DBS after 90 min of stimulation in clinical trials and research studies. © 2008 Movement Disorder Society
Susceptibility genes in movement disorders
Authors: Scholz Sonja , Singleton Andrew 
Published: March 2008

AbstractDuring the last years, remarkable progress in our understanding of molecular genetic mechanisms underlying movement disorders has been achieved. The successes of linkage studies, followed by positional cloning, have dominated the last decade and several genes underlying monogenic disorders have been discovered. The pathobiological understanding garnered from these mutations has laid the foundation for much of the search for genetic loci that confer risk for, rather than cause, disease. With the introduction of whole genome association studies as a novel tool to investigate genetic variation underlying common, complex diseases, a new era in neurogenomics has just begun. As the field rapidly moves forward several new challenges and critical questions in clinical care have to be addressed. In this review, we summarize recent advances in the discovery of susceptibility loci underlying major movement disorders, explain the newest methodologies and tools employed for finding and characterizing genes and discuss how insights into the molecular genetic basis of neurological disorders will impact therapeutic concepts in patient care. © 2008 Movement Disorder Society
Is there a glass ceiling for women in development?
Authors: Sampson Susan D. , Moore Lynda L. 
Published: March 2008

AbstractThis article reports the results of an empirical study of salary equity for Women in Development of Greater Boston. The study objectives were to examine whether a glass ceiling exists for women in development in the New England area and develop a historical review of equity progress as compared to previous studies. Issues specific to women in the development field were identified and recommendations given to address identified needs. The findings substantiate the existence of a glass ceiling with a significant difference in average salary and representation in upper management. Furthermore, the study revealed that the salary gap between men and women is widening over time. Perceptions of barriers to women's advancement and organizational practices that would contribute to equity were also assessed. Recommendations for future research and organizational practices are presented.
Are we overestimating the number of cell-cycling genes? The impact of background models on time-series analysis
Authors: Futschik Matthias E. , Herzel Hanspeter 
Published: March 2008

Abstract
Motivation: Periodic processes play fundamental roles in organisms. Prominent examples are the cell cycle and the circadian clock. Microarray array technology has enabled us to screen complete sets of transcripts for possible association with such fundamental periodic processes on a system-wide level. Frequently, quite large numbers of genes have been detected as periodically expressed. However, the small overlap between genes identified in different studies has cast some doubts on the reliability of the periodic expression detected.
Results: In this study, comparative analysis suggests that the lacking agreement between different cell-cycle studies might be due to inadequate background models for the determination of significance. We demonstrate that the choice of background model has considerable impact on the statistical significance of periodic expression. For illustration, we reanalyzed two microarray studies of the yeast cell cycle. Our evaluation strongly indicates that the results of previous analyses might have been overoptimistic and that the use of more suitable background model promises to give more realistic results.
Availability: R scripts are available on request from the corresponding author.
Contact: matthias.futschik@charite.de
Supplementary information: Supplementary materials are available at Bioinformatics online.
Complex Regional Pain Syndrome (CRPS/RSD) and Neuropathic Pain: Role of Intravenous Bisphosphonates as Analgesics
Authors: Yanow Jennifer , Pappagallo Marco , Pillai Letha 
Published: March 2008

Neuropathic pain is a sequela of dysfunction, injuries, or diseases of the peripheral and/or central nervous system pain pathways, which has historically been extremely difficult to treat. Complex regional pain syndrome (CRPS) types 1 and 2 are neuropathic pain conditions that have a long history in the medical literature but whose pathophysiology remains elusive and whose available treatment options remain few. While an exact animal model for CRPS doesn't yet exist, there are several animal models of neuropathic pain that develop behaviors of hypersensitivity, one of the hallmark signs of neuropathic pain in humans.Bisphosphonates have been used for pathologic conditions associated with abnormal bone metabolism, such as osteoporosis, Paget’s disease and cancer-related bone pain for many years. More recently, results of clinical trials have indicated the potential role of bisphosphonates in the treatment of CRPS/RSD.In this paper we will review the preclinical studies regarding the use of bisphosphonates as analgesics in animal models of neuropathic pain, and also summarize the clinical trials that have been done to date. We will give an overview of bisphosphonate pharmacology and discuss several potential mechanisms by which bisphosphonates may be analgesic in CRPS/RSD and bone pain of noncancer origin.
Potential Sites of Bioactive Gibberellin Production during Reproductive Growth inArabidopsis
Authors: Hu Jianhong , Mitchum Melissa G. , Barnaby Neel , Ayele Belay T. , Ogawa Mikihiro , Nam Edward , Lai Wei-Chu , Hanada Atsushi , Alonso Jose M. , Ecker Joseph R. , Swain Stephen M. , Yamaguchi Shinjiro , Kamiya Yuji , Sun Tai-ping 
Published: March 2008

AbstractGibberellin 3-oxidase (GA3ox) catalyzes the final step in the synthesis of bioactive gibberellins (GAs). We examined the expression patterns of all four GA3ox genes in Arabidopsis thaliana by promoter–β-glucuronidase gene fusions and by quantitative RT-PCR and defined their physiological roles by characterizing single, double, and triple mutants. In developing flowers, GA3ox genes are only expressed in stamen filaments, anthers, and flower receptacles. Mutant plants that lack both GA3ox1 and GA3ox3 functions displayed stamen and petal defects, indicating that these two genes are important for GA production in the flower. Our data suggest that de novo synthesis of active GAs is necessary for stamen development in early flowers and that bioactive GAs made in the stamens and/or flower receptacles are transported to petals to promote their growth. In developing siliques, GA3ox1 is mainly expressed in the replums, funiculi, and the silique receptacles, whereas the other GA3ox genes are only expressed in developing seeds. Active GAs appear to be transported from the seed endosperm to the surrounding maternal tissues where they promote growth. The immediate upregulation of GA3ox1 and GA3ox4 after anthesis suggests that pollination and/or fertilization is a prerequisite for de novo GA biosynthesis in fruit, which in turn promotes initial elongation of the silique.
The world is still round – like a soccer ball: redefining global strategy
Authors: Ghemawat Pankaj 
Published: March 2008

PurposeThe paper aims to look at the sustained differences among countries in devising and evaluating marketing strategies.Design/methodology/approachThe paper uses the example of football to illustrate this view of globalization.FindingsThe paper finds that border‐crossing businesses need to pay more attention to the sustained differences among countries in devising and evaluating strategies.Originality/valueThe paper offers interesting views on the development of globalized marketing strategies.
Interview with Will King
Authors: by Rachel Brown Interview 
Published: March 2008

PurposeThe paper aims to present an interview with Will King, founder of King of Shaves, and a leading entrepreneur.Design/methodology/approachThis briefing is prepared by an independent interviewer.FindingsAnswers are provided on a range of topics founder of King of Shaves, leading entrepreneur: the are of marketing male grooming/cosmetics, and brand development and expansion..Practical implicationsThe paper provides strategic insights and practical thinking that have influenced some of the world's leading organizations.Originality/valueThe briefing saves busy executives and researchers hours of reading time by selecting only the very best, most pertinent information and presenting it in a condensed and easy‐to‐digest format.
Cleaning management of owner‐operated real estate
Authors: Stoy Christian , Johrendt Reinhold 
Published: March 2008

PurposeThe costs of cleaning owner‐operated office buildings amount to an approximate 20 per cent share of the operating costs. As a result of their cost relevance and the growing cost pressures on real estate divisions, cleaning costs are increasingly coming under focus. This interest manifests itself in the search for cost indicators and their drivers to be used as a basis for the management of real estate. This paper seeks to address this issue.Design/methodology/approachA study of the specialist literature revealed, from a theoretical perspective, the relevant drivers of cleaning costs. The empirical study is based on cost and property information collected, on a uniform basis, from over 100 owner‐operated office buildings in Switzerland, with the analysis of cost drivers being carried out using regression analysis.FindingsThe cleaning cost indicators of the examined properties revealed a median of 41 CHF/m2 usable floor area and year. With regard to cost drivers, it was established that both building characteristics and usage determine the costs. However, the decisive drivers are, above all, the management strategies and the owners' main objectives.Research limitations/implicationsThe management strategies proved to be specific to the individual project partners. The causal relationships between strategies (e.g. outsourcing strategies) and costs may be considered to be well‐substantiated hypotheses, which require verification by means of future analyses.Originality/valueThe study identified both indicators and relevant drivers of cleaning costs. To this end, this study collected data from over 100 owner‐operated office buildings within Switzerland and examined these data using regression analysis. As a result, the cleaning costs of the examined properties were ascertained.
The indoor condition guarantee procedure and associated lease contract model
Authors: Saari Arto , Takki Tarja 
Published: March 2008

PurposeNumerous studies have shown that indoor environment affects health and performance, which in turn affect productivity. Property owners have not utilized Indoor Environment Quality (IEQ) as a value‐added factor to market the office spaces. On the other hand, tenants have not had a tool to demand certain indoor conditions. The paper aims to present one market mechanism for including IEQ in office space supply: the office lease contract model entitled Indoor Environment Quality.Design/methodology/approachThe research included a constructive search for a lease contract model for the problems presented above. The need for this novel lease model is proved by the financial calculations.FindingsThe lease contract procedure whereby a lessor issues a condition guarantee to a tenant consists of: technical building audit process; and entering the terms of the indoor condition guarantee in the lease contract. It makes sense for the owner to invest in a favourable indoor environment if the benefits are shared. An owner's monetary benefit from improved IEQ is also greatly related to longer lease periods. When tenants stay longer in the same facility there is less empty office space and less need for alterations by new tenants. Therefore, rental income is higher and alteration costs are lower, which in turn lead to higher profitability of the property owner's business.Originality/valueThe lease model proposed forms guidelines for taking account of the indoor air quality in lease contracts.
Modelling the relationship between business cycles and office location
Authors: Dettwiler Paul 
Published: March 2008

PurposeThe purpose of this paper is to create a model of FM and location variables in the dimensions of location and recessions.Design/methodology/approachThe approach is based on statistical analysis and quantitative methodology.FindingsSignificant differences and correlations argue for four settings with different features, first, in the dimension of single or multiple site locations, and second, the dimension in low and high growth of GDP, here termed “recession” and “boom”, respectively.Research limitations/implicationsThis paper is a relevant study for growth firms in multiple facilities management perspectives.Practical implicationsA better knowledge and decision basis related to relocation and behaviour of FM during fluctuations of GDP is expected.Originality/valueThe paper presents a survey of FM‐related data that covers an entire nation and all major business sectors, collected concerning two successive periods, and analysed.
ABES – the Bibliographic Agency for Higher Education: its role in the resource sharing of documents in French universities and in document supply
Authors: Bérard Raymond 
Published: March 2008

PurposeThis paper seeks to describe the role and the development of the French bibliographic agency, ABES. More generally, it aims to describe the state of bibliographic and document supply developments in France and possible futures.Design/methodology/approachThe paper is descriptive in nature.FindingsThe findings of the paper are that it is necessary to reduce the ILL failure rate, to reduce supply times, to capitalise on the streamlining of document supply, to improve the quality of supply, and to harmonise terms and conditions.Originality/valueThe paper is written by an authoritative figure in the French library network. It will be relevant to all those interested in developments in document supply and bibliographic organisation in France.
UnityUK celebrates its second birthday: a paradigm shift for UK public libraries
Authors: Birch Katie 
Published: March 2008

PurposeThe purpose of this paper is to explain the UnityUK service and its benefits to the user community.Design/methodology/approachThe paper takes the form of a factual review of the UnityUK service.FindingsThe paper finds that the UnityUK service is changing the way inter‐library loans work in the UK.Originality/valueThe paper shares experiences of the UK market with the wider community.
The use of scholarly electronic journals at the Indian Institute of Science: a case study in India
Authors: Galyani Moghaddam Golnessa , Talawar V.G. 
Published: March 2008

PurposeThe purpose of this paper is to investigate the use of scholarly electronic journals at the Indian Institute of Science.Design/methodology/approachThe paper examines the methodology and results from a questionnaire‐based survey of networked electronic services in India at the Indian Institute of Science (IISc) libraries, serving a variety of disciplines. A random sample of the main cohort was selected and, during five months from January 2004 until May 2004, 700 copies of the questionnaire were distributed among 40 departments of IISc; 397 completed and valid questionnaires (56.7 per cent) were received.FindingsThe results showed a growing interest in electronic journals among the users at IISc. Electronic journals were mostly used for research needs and PDF was the most preferred format. The fact that users have free access to electronic journals at all hours from their own computers seems to be the most appealing feature.Research limitations/implicationsThere are many factors that may affect the use of scholarly electronic journals. An attempt is made in this study to see how these resources are being used in a multi‐disciplinary institute in India. Limiting its focus to one institute, this paper provides useful empirical evidence for library staff and the research community.Practical implicationsThe results of the study will be useful for library staff at IISc and similar institutes in India.Originality/valueThe paper provides original data from Indian end users regarding their use of scholarly electronic journals.
Managing document supply: a SAGA come true in Sweden
Authors: Gavel Ylva , Hedlund Lars O.A. 
Published: March 2008

PurposeThe purpose of this paper is to describe how SAGA, a system for managing the library operations associated with document supply, was successfully developed using a very informal project model.Design/methodology/approachThe project model and system architecture are described.FindingsInitially, SAGA was tailored for the needs of the medical library at Karolinska Institutet in Sweden. Subsequently, it has been implemented at other Swedish academic libraries. The system has features for automating the workflows associated with document supply for both loans and copies externally and internally. It integrates document requests from a diversity of ordering systems under a single interface. The methodology adopted when implementing the system suggests that an incremental approach sometimes has benefits over a more formal pre‐planned approach.Practical implicationsThe project model described may be applied to development projects at other libraries. The system architecture may be applied to other systems for managing document supply.Originality/valueThe SAGA approach relies on managing requests placed in different systems via a single interface rather than trying to direct customers to a single ordering system.
The Swedish LIBRIS system offers new web facilities for searching and ILL to librarians and to the general public
Authors: Sagnert Britt 
Published: March 2008

PurposeThe purpose of this paper is to give a general overview of the Swedish LIBRIS system and its database, the search facilities of LIBRIS WebSearch and the ILL services for libraries and end users.Design/methodology/approachThe paper describes the contents of the LIBRIS database and the different services of the four national library systems – LIBRIS WebSearch, LIBRIS ILL, the Patron Request Routine, and the Library Directory.FindingsDuring the development process of the new versions of LIBRIS WebSearch and LIBRIS ILL the specific needs of the end user have been the priority, with the aim to create simple, intuitive and easily available systems.Originality/valueThe paper presents the recent development of the two national LIBRIS systems – LIBRIS WebSearch and LIBRIS ILL. The workflow of LIBRIS ILL for libraries and end users is described in detail.
The changing use of electronic document delivery in the inter‐library loan service: a survey
Authors: Walton Judith 
Published: March 2008

PurposeThe purpose of this paper is to outline findings of a recent MSc study into electronic article provision in interlending and document supply presented to the Robert Gordon University in June 2007.Design/methodology/approachThe paper is primarily based on data from questionnaires circulated to UK ILL departments (in academic, public, industrial, health and special libraries), recent users of ILL in a UK academic library and library managers within UK academic HE and public libraries.FindingsElectronic document delivery was found to be used by half of libraries who responded: it was widespread in academic libraries, but seldom used in public libraries where demand for articles is comparatively low. Academic users appreciate the move to desktop delivery and the trend towards electronic delivery of articles in ILL is expected to grow in the future.Research limitations/implicationsThe paper is based on a survey data of libraries and users (in an academic environment) in the UK and Ireland. As such it provides a snapshot of the situation and represents the views of the participants at that time.Practical implicationsThe user survey shows that, in an academic context, users welcome the move to desktop delivery.Originality/valueThis paper provides a snapshot of the prevalence of, and attitudes to, electronic article delivery within the UK and Ireland.
Interlending and document supply: a review of the recent literature: 62
Authors: McGrath Mike 
Published: March 2008

PurposeThe purpose of this paper is to provide a review of the most recent literature concerning document supply and related matters.Design/methodology/approachThe approach is based on the reading of over 150 journals as well as monographs, reports and web sites.FindingsIt was found that the fundamental debate on the direction of scholarly publishing continues intensely. Electronic books remain a minority market but the literature at least remains optimistic. The mass digitisation of books continues apace. Open access continues to grow but with continuing and widely differing views on its impact.Originality/valueThe paper represents a useful source of information for librarians and others interested in document supply and related matters.