bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Net Clinical Benefit of Fondaparinux vs LMWH in Chinese Non-ST-Segment Elevation Acute Coronary Syndrome Patients: the REFOCAS Nonrandomized Controlled Trial
Authors: Li Dandan , Tuo Xiaodan , Yu Yani , Ma Genshan , Gao Chuanyu , Mao Wei , Qu Peng , Liu Limin , Shang Zhuo , Yin Xunli , Wang Guozhen , Liu Aifen , Chen Yundai 
Published: February 2025

AbstractBackground and aimsIn Chinese patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS), it is essential to evaluate the net clinical benefit (NCB) of fondaparinux compared to low molecular weight heparin (LMWH) in NSTE-ACS patients with varying bleeding and ischemic risks.MethodsThis multicenter, prospective, open-label, real-world study enrolled 8066 adult patients undergoing non-emergency percutaneous coronary intervention (PCI) at 88 hospitals from July 2019 to July 2021. Patients received fondaparinux (2.5 mg/d) or LMWH (1 mg/kg, twice/day) were followed up within 6 months. The GRACE and CRUSADE scores were used to stratify the included patients. The primary outcome was the incidence of NCB event (all-cause death, reinfarction, nonfatal stroke, or BARC≥ type 2 bleeding) at 30 days.ResultsA total of 5430 patients received fondaparinux and 2636 received LMWH. The NCB outcome occurred in 136 patients (2.5%) receiving fondaparinux and in 110 patients (4.2%) receiving LMWH [HR=0.594 (95% CI: 0.462, 0.764), p<0.001]. The 30-day incidence of BARC≥2 bleeding was significantly lower in the fondaparinux group compared with the LMWH group [68 (1.3%) vs. 66 (2.5%), HR=0.498 (95% CI: 0.355, 0.699), p<0.001].Among patients with lower risk, defined by GRACE score≤140 and CRUSADE scores≤40, fondaparinux significantly reduced the incidence of MACE and BARC ≥ 2 bleeding. Fondaparinux decreased the risk of BARC≥2 bleeding across different risk groups, with absolute risk reductions (ARD) of -0.9% for CRUSADE score≤40, -3.0% for CRUSADE score>40, -1.2% for GRACE score≤140, and -1.7% for GRACE score>140, indicating a more pronounced protective effect in individuals at high bleeding risk.ConclusionsIn Chinese patients with NSTE-ACS, fondaparinux effectively diminished the incidence of the NCB event of 30 days compared with LMWH. Additionally, fondaparinux exhibited superior safety than LMWH in patients with high bleeding risk, consistently outperformed LMWH in terms of efficacy and safety in the low-risk group as well.
NOR1and Mitophagy: An Insight into Sertoli Cell Function Regulating Spermatogenesis
Authors: Pradhan Bhola Shankar , Das Deepyaman , Sarkar Hironmoy , Bhattacharya Indrashis , Majumdar Subeer S 
Published: February 2025

AbstractThe development and differentiation of germ cell (Gc) is supported by the Sertoli cel (Sc). We previously reported that a developmental switch in Sc around 12 days of age onwards in rats. During the process of differentiation of Sc, the differential expression of mitophagy-related genes and its role in male fertility is poorly understood. To address this gap, we evaluated the microarray dataset GSE48795 to identify 12 mitophagy-related hub genes -Egfr, Bcl2, Ccl2, Mmp2, Igf1, Fgf7, Apoe, Fos, Cxcl12, Ocln, Dcn,andSnca. We identifyNOR1as a potential mitophagy-related gene of interest due to its strong regulatory association with two hub genes Bcl2 and Fos. To determine the importance of our analysis of finding key mitophagy-related genes, we generated a transgenic rat model with Sc-specific knockdown ofNOR1during puberty. Adult male transgenic rats were found to be infertile due to impaired spermatogenesis, indicating a critical role forNOR1in Sc function. These findings suggest that mitophagy-related genes may play an important role in the differentiation of Sc and thereby, regulate male fertility.
Historic mine waste contains diverse microbial communities that reflect waste type and geochemistry
Authors: Best Mackenzie B. , Kazemi Motlagh Zohreh , McLemore Virginia T. , Jones Daniel S. 
Published: February 2025

ABSTRACTWaste rock and tailings left behind by historic mining operations can contain substantial critical mineral resources. However, over the decades and centuries since these deposits were emplaced, microbial communities developed that can catalyze rock weathering and elemental cycling, which could have impacted the economic resources but also might be harnessed for future biomining or other metal recovery efforts. Here we combined cell counting, rRNA gene and transcript sequencing, and whole rock geochemistry to compare the composition and abundance of microbial communities from five inactive mine sites in South-Central New Mexico that contain critical minerals. While acidic seeps and adits at the sites contained organisms commonly found in acid rock drainage and bioleaching operations, these organisms were only present at very low abundance in the waste rock and tailings, which were instead dominated by bacteria and archaea that mostly represent inorganic nitrogen- and organic carbon-oxidizing populations. Generally, rRNA transcript libraries contained many of the same organisms as rRNA gene libraries, indicating that most of these microbial populations are active. Differences among total and active communities correspond to waste rock geochemistry, including concentrations of sulfur, iron, and other variables such as copper, lead, and rare earth elements. Nevertheless, many of the rRNA gene and transcript sequences in these deposits were from groups without cultured representatives, and these unknown microorganisms are likely important for biogeochemical cycling over the long lifetime of these waste deposits. We also discuss recommendations for microbiological assessment of similar large historic mine waste deposits.IMPORTANCENew Mexico has a long history of mining, with hundreds of mining districts across the state, many of which contain inactive operations with historic tailings and waste rock. Because metallurgical processing was in its infancy when most of these mines were active, they contain substantial metal resources in tailings and waste rock that could be used to support domestic demand for critical minerals. We found that microbial communities associated with these deposits do not represent typical bioleaching communities, and instead are dominated by taxa not typically associated with mine wastes. However, the deposits do contain rare iron and sulfur-cycling taxa that could catalyze metal mobilization, as well as active populations of novel microorganisms that are likely important for biogeochemical cycling. These mine waste-associated microbial communities could represent important resources for bioremediation and other biotechnological applications to recover valuable elements from these and other historic mine waste deposits.
Physiologic recovery ofMycobacterium tuberculosisfrom drug injury: A molecular study of post antibiotic effect in mice
Authors: Hendrix Jo , Mubarak Reem Al , Bateman Adeline , Massoudi Lisa M. , Rossmassler Karen , Kaya Firat , Zimmerman Matthew D. , Wynn Elizabeth A. , Voskuil Martin I. , Robertson Gregory T. , Moore Camille M. , Walter Nicholas D. 
Published: February 2025

AbstractPost-antibiotic effect (PAE) describes the delayed recovery of bacteria following antibiotic exposure. PAE is thought to underlie tuberculosis (TB) treatment forgiveness,i.e.the capacity of regimens to tolerate non-adherence. The basis of PAE inMycobacterium tuberculosis(Mtb) remains poorly understood, partly because PAE has conventionally been measured based on change inMtbburdenin vitrorather than change inMtbphysiologyin vivo. We investigatedMtbphysiologic recovery in the BALB/c mouse model following sub-curative 2- and 4-week durations of the standard isoniazid, rifampin, pyrazinamide, ethambutol (HRZE) treatment. Measurement of rRNA synthesis via the RS ratio® and the entire transcriptome via SEARCH-TB elucidated the dynamics of physiologic recovery.Mtbburden did not increase over 28 days of drug-free post-treatment recovery, indicating prolonged PAEin vivo.The RS ratio indicated thatMtbribosomal RNA synthesis resumed within four days of treatment interruption. However, transcriptional changes indicative of metabolic reactivation were delayed for over two weeks. Processes critical for replication, including expression of genes involved in protein and cell wall synthesis, remained suppressed throughout 28 days post-treatment. Longer treatment induced more extensive physiologic perturbation and was associated with slower and less complete recovery.Expression of processes that are typically induced by environmental stress (e.g., DosR regulon, universal stress proteins, and heat shock proteins) exhibited the reverse, decreasing during drug treatment and rising during recovery.These findings provide a new basis for understanding PAE based on drug-induced injury and physiologic recovery. Following relatively short durations of HRZE, physiologic recovery ofMtbwas a slow, sequential and incomplete processin vivo.Our observation that longer treatment resulted in even slower recovery suggests thatMtbmay progressively lose capacity to recover. This work establishes a tractable experimental framework for quantifying the forgiveness of new TB treatment regimensin vivo.
Reorganization of motor functions within visuomotor networks subsequent to somatosensory cortical damage
Authors: Liu Yuqi , Halfen Elizabeth J. , Yau Jeffrey M. , Fischer-Baum Simon , Kohler Peter , Faseyitan Olufunsho , Coslett H. Branch , Medina Jared 
Published: February 2025

AbstractSomatosensory inputs are critical to motor control. Animal studies have shown that primary somatosensory lesions cause sensorimotor deficits along with disrupted organization in primary motor cortex (M1). How does damage in primary somatosensory cortex (S1) influence motor networks in humans? Using fMRI, we examined two individuals with extensive damage to left somatosensory cortex, but primarily intact motor cortex and preserved motor abilities. Given left S1 damage, tactile detection and localization were impaired for the contralesional hand in both individuals. When moving the contralesional hand, LS, with near complete damage to the S1 hand area, showed increased activation in ipsilesional putamen and deactivation in contralesional cerebellum relative to age-matched controls. These findings demonstrate influences of S1 damage to subcortical sensorimotor areas that are distant from the lesion site, and a potential reweighting of the motor network with increased action selection in putamen and inhibition of sensory prediction in cerebellum in the face of sensory loss. In contrast, RF, who had a small island of spared S1 in the hand area, showed greater activation in contralesional S1 for movement versus rest. This same region was also activated by pure somatosensory stimulation in a second experiment, suggesting that the spared S1 area in RF still subserves sensorimotor processing. Finally, the right middle occipital gyrus was more strongly activated in both individuals compared with controls, suggesting a potential reliance on visual imagery in the face of degraded sensory feedback.
Analysis of the data on differential cross sections and spin density matrix elements for
γp→ρ0p
Authors: Wang Ai-Chao , Wei Neng-Chang , Huang Fei 
Published: February 2025

The newly published data on spin density matrix elements from the GlueX Collaboration, along with the previously released differential cross-section data from the CLAS Collaboration and the other two experiments for the γp→ρ0p reaction, are systematically investigated using an effective Lagrangian approach within the tree-level Born approximation. The model combines contributions from t-channel meson exchanges (π, η, and f2), s-channel nucleon (N) and nucleon resonance (N*) exchanges, u-channel N exchange, and a generalized contact term to construct the scattering amplitudes. Regge propagators are employed for t-channel amplitudes to incorporate the contributions from mesons with various spins lying on the same trajectories. The analysis shows that the background contributions, dominated by the f2-trajectory exchange, provide a satisfactory description of the data in the high-energy and forward-angle regions. The inclusion of specific nucleon resonances, such as N(2100)1/2+, N(2060)5/2−, or Δ(2000)5/2+, significantly improves the description of the differential cross-section data at near-perpendicular scattering angles in the low-energy region. Predictions of photon beam and target nucleon asymmetries are provided, offering valuable insights to discriminate reaction mechanisms when corresponding data become available in the future.

Published by the American Physical Society
2025
Unveiling how business process management capabilities foster dynamic decision-making for effectiveness of sustainable digital transformation
Authors: Huy Pham Quang , Phuc Vu Kien 
Published: February 2025

PurposeThis research aims at investigating how business process management capabilities (BPMC) impact the effectiveness of sustainable digital transformation (ESDT). Furthermore, it delves into the mediation of dynamic decision-making (DDM) in the relationship between BPMC and ESDT.Design/methodology/approachThis research employed the hypothetico-deductive technique. The statistical database was generated from sample of 712 respondents from small and medium companies (SMEs) in Vietnam, utilizing convenience and snowball sampling methods. The two-step process utilizing structural equation modeling, supported by SmartPLS version 4.1.0.9 and AMOS 28, was employed to assess the measurement model, while SmartPLS version 4.1.0.9 was used to evaluate the structural model.FindingsThe results of the analysis emphasize significant and positive correlations between the proposed constructs related to significance and effect size. The statistical results indicated that BPMC had a significant and beneficial effect on ESDT. This relationship was partially mediated by DMM.Practical implicationsThe salient point emphasized that practitioners should prioritize enhancing focus on BPMC and DDM, as this would significantly facilitate more comprehensive solutions, enabling SMEs to achieve optimal success in sustainable digital transformation. Policymakers and government influencers are urged to concentrate on innovative attributes and ensure a conducive environment for the implementation of innovation by enacting regulations that promote the application of digital technology.Originality/valueThe findings of this study will broaden scholars’ understanding of the influence of BPMC on ESDT. The originality of the research is to provide research directions for advancing studies on the role of DDM in the context of sustainable digital transformation.
Prediction of surrounding rock grade for ultra-deep roadway engineering using BPNN combined with optimal algorithms
Authors: Yu Bingbing , Wang Guohao , Cheng Weixian , Wang Bo , Li Yi , Yang Zhen 
Published: February 2025

PurposeThis paper attempts to combine the application of artificial intelligence in predicting and evaluating the classification of surrounding rock grades and provides guidance for subsequent support design and reinforcement support operations.Design/methodology/approachThis paper discusses the use of BPNN as the primary tool, combined with three swarm bionic optimization algorithms (GA, PSO, GWO), to solve stability evaluation and grade prediction of surrounding rock in ultra-deep roadway excavation.FindingsTaking the Great Wall ore group as the core and the Shanghaimiao mining area as the extension, the optimal model is applied to the classification of surrounding rock grade in ultra-deep roadway engineering. Prediction results show that the performance of BPNN models is excellent.Research limitations/implicationsDue to the limitations of geological conditions and construction environment in deep coal mines, the period of roadway excavation is too long, resulting in less data collection.Practical implicationsThe prediction results can provide guidance for the excavation method, support scheme correction and reinforcement support scheme design of deep coal mine roadway engineering.Social implicationsIt provides guidance for deep mining of coal mine (the premise of surrounding rock support stability), so as to ensure the economic and safety benefits of coal enterprises.Originality/valueThe neural network is applied to rock mechanics in a deep site for the first time, which is used to solve the prediction direction of surrounding rock grade evaluation. The index of the input layer is determined by combining the “three high and one disturbance” with the on-site construction situation, which is closer to the actual project. The swarm intelligent bionic algorithms are selected to optimize the hyperparameters of back propagation neural network, so as to improve the accuracy of the models. The classification and evaluation system of surrounding rock for the Great Wall ore group is constructed, which is the core of Shanghaimiao mining area in the northwest of China, guiding the dynamic adjustment of on-site excavation and support operations.
Resilience of Islamic and conventional equity markets in turbulent times
Authors: Jahromi Maria 
Published: February 2025

PurposeThe purpose of this study is to examine the resilience of Islamic equities during crisis periods and in times of financial distress and how the industry composition and other characteristics of Islamic financial markets contribute to this resilience.Design/methodology/approachThis study uses panel regressions, pooled regressions and EGARCH models to analyse the impact of various crisis periods and financial distress on the returns and the volatility of Islamic and conventional equities. The main sample covers 48 Islamic and conventional equity indices from 1996 to 2023.FindingsIslamic equity indices are more stable than conventional equity indices during various financial crises and the COVID-19 pandemic. These findings also hold for continuous measures of financial distress and a global crisis index. Industry composition contributes substantially to the relative resilience of Islamic equities. Many performance differences reduce or disappear once controlling for industry. There are additional protective factors of Islamic equities including lower leverage and the exclusion of volatile assets.Practical implicationsThe findings provide valuable insights for index construction, risk management and diversification strategies in times of financial instability. Diversification across Shari’ah-compliant firms and industries is beneficial.Originality/valueThis study provides a comprehensive analysis of resilience among Islamic equities in turbulent times, covering multiple binary and continuous measures of financial crises and financial distress. Importantly, it considers the role of industry composition and other factors in contributing to their resilience. These results have implications for index construction and for risk management and diversification strategies in turbulent times.
Impact of supplier trust and integrated technology on supply chain resilience for sustainable supply chain in FMCG sector
Authors: Rashid Aamir , Rasheed Rizwana , Rahi Samar , Amirah Noor Aina 
Published: February 2025

Purpose
The Fast Moving Consumer Goods (FMCG) sector is a critical component of the global economy, providing consumers with a wide range of products that are consumed daily. However, this sector faces vulnerability during disruptions. Therefore, this research amid to examine the effect of supplier trust and integrated technology on supply chain resilience (SCR) for sustainable supply chains in the FMCG sector.

Design/methodology/approach
Data was collected from 409 respondents from the FMCG sector in the United States. The hypotheses were tested using Structural Equation Modeling through SmartPLS. The study findings found that all the direct and mediating hypotheses were supported.

Findings
The findings suggest that better supplier trust and the use of integrated technology enhance the capability of an organization to better respond to disruptions. It makes the supply chain more resilient. Further, SCR brings sustainable supply chains to the FMCG sector. Similarly, SCR is a significant mediator in the relationships between independent and dependent variables, highlighting the importance of resilient supply chains.

Originality/value
This research contributes to the literature on study variables and the Dynamic Capability View theory, as supplier trust integrated technologies are crucial factors in building resilient supply chains. This research has several managerial implications, including managers’ need to prioritize building trust with suppliers to facilitate increased information sharing. They should invest in integrated technologies to sense, forecast and be proactive in building SCR and, eventually, a sustainable supply chain.
Embracing digital business ecosystem: transforming traditional marketplaces
Authors: Almunawar Mohammad Nabil , Anshari Muhammad , Ordoñez De Pablos Patricia , Fauzi Anas Miftah 
Published: February 2025

Purpose
This paper aims to devise a framework for mapping and designing business ecosystems and to demonstrate its effectiveness in crafting digital transformation for traditional marketplaces.

Design/methodology/approach
A digital business ecosystem framework is developed as a Value Exchange Network (VEN) to analyze both the existing marketplace business ecosystem and a prospective digital marketplace ecosystem. The transformation process is divided into four stages. The first stage begins with describing the case and mapping it onto the framework as a business ecosystem depicted in a Value Exchange Network Diagram (VEND). In the second stage, a future or new business ecosystem is designed and represented using VEND. The third stage involves developing guidelines for the digital transformation. Finally, the fourth stage focuses on creating a management tool to operate and expand the new digital business ecosystem.

Findings
Traditional marketplaces in Indonesia face significant threats from hypermarkets, supermarkets, minimarkets and the growing preference of the younger generation for digital marketplaces, especially after the COVID-19 pandemic. Our framework (VEN) offers a structured approach to support traditional marketplaces in undergoing digital transformation through four stages.

Research limitations/implications
This paper showcases the expressive power of our business ecosystem framework. The digital transformation of the traditional marketplace presented here serves as an example application of the framework. However, the framework has yet to be tested in a real-world digital transformation project.

Practical implications
This paper offers direction and guidelines for the digital transformation journey of traditional marketplaces using the VEN framework.

Originality/value
This paper uses an innovative framework for mapping, analyzing and constructing business ecosystems, presenting a four-stage method to outline the digital transformation of traditional marketplaces. The adoption of ecosystem thinking in the pursuit of digitally transforming conventional marketplaces is novel, offering a comprehensive approach to this transformation.