bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lipid metabolism-related long noncoding RNA RP11-817I4.1 promotes fatty acid synthesis and tumor progression in hepatocellular carcinoma
Authors: Wang Ren-Yong , Yang Jia-Ling , Xu Ning , Xu Jia , Yang Shao-Hua , Liang Dao-Ming , Li Jin-Ze , Zhu Hong 
Published: February 2024

BACKGROUND
Hepatocellular carcinoma (HCC) is one of the most common types of tumors. The influence of lipid metabolism disruption on the development of HCC has been demonstrated in published studies.
AIM
To establish an HCC prognostic model for lipid metabolism-related long non-coding RNAs (LMR-lncRNAs) and conduct in-depth research on the specific role of novel LMR-lncRNAs in HCC.
METHODS
Correlation and differential expression analyses of The Cancer Genome Atlas data were used to identify differentially expressed LMR-lncRNAs. Quantitative real-time polymerase chain reaction analysis was used to evaluate the expression of LMR-lncRNAs. Nile red staining was employed to observe intracellular lipid levels. The interaction between RP11-817I4.1, miR-3120-3p, and ATP citrate lyase (ACLY) was validated through the performance of dual-luciferase reporter gene and RIP assays.
RESULTS
Three LMR-lncRNAs (negative regulator of antiviral response, RNA transmembrane and coiled-coil domain family 1 antisense RNA 1, and RP11-817I4.1) were identified as predictive markers for HCC patients and were utilized in the construction of risk models. Additionally, proliferation, migration, and invasion were reduced by RP11-817I4.1 knockdown. An increase in lipid levels in HCC cells was significantly induced by RP11-817I4.1 through the miR-3120-3p/ACLY axis.
CONCLUSION
LMR-lncRNAs have the capacity to predict the clinical characteristics and prognoses of HCC patients, and the discovery of a novel LMR-lncRNAs, RP11-817I4.1, revealed its role in promoting lipid accumulation, thereby accelerating the onset and progression of HCC.
desafíos de las relaciones laborales ante la inteligencia artificial
Authors: Delgue Juan Raso 
Published: February 2024

El creciente impacto de la Inteligencia Artificial en las relaciones laborales obliga a los Estados y a las organizaciones de empleadores y trabajadores ha enfrentar nuevos desafíos, para los cuales no estamos siempre preparados. Reconocemos ese impacto en la gestión de la empresa, en los ritmos de producción cada vez más estresantes, en los controles sobre los trabajadores cada vez más intensos, en la sustitución de trabajos tradicionales por la acción de los robots.
El legislador no logra seguir el paso de las nuevas tecnologías, por lo cual es necesario recurrir a nuevas fuentes de derecho, como lo principios generales y laborales, el derecho comparado y las normas sobre protección de datos. En este proceso es indispensable despertar el interés de empleadores y trabajadores para abrir espacios de diálogo y negociación.
Large Interferometer For Exoplanets (LIFE). XII. The Detectability of Capstone Biosignatures in the Mid-infrared—Sniffing Exoplanetary Laughing Gas and Methylated Halogens
Authors: Angerhausen Daniel , Pidhorodetska Daria , Leung Michaela , Hansen Janina , Alei Eleonora , Dannert Felix , Kammerer Jens , Quanz Sascha P. , Schwieterman Edward W. ,   The LIFE initiative
Published: February 2024

Abstract
This study aims to identify exemplary science cases for observing N2O, CH3Cl, and CH3Br in exoplanet atmospheres at abundances consistent with biogenic production using a space-based mid-infrared nulling interferometric observatory, such as the Large Interferometer For Exoplanets (LIFE) mission concept. We use a set of scenarios derived from chemical kinetics models that simulate the atmospheric response of varied levels of biogenic production of N2O, CH3Cl, and CH3Br in O2-rich terrestrial planet atmospheres to produce forward models for our LIFEsim observation simulator software. In addition, we demonstrate the connection to retrievals for selected cases. We use the results to derive observation times needed for the detection of these scenarios and apply them to define science requirements for the mission. Our analysis shows that in order to detect relevant abundances with a mission like LIFE in its current baseline setup, we require: (i) only a few days of observation time for certain very nearby “golden target” scenarios, which also motivate future studies of “spectral-temporal” observations (ii) ∼10 days in certain standard scenarios such as temperate, terrestrial planets around M star hosts at 5 pc, (iii) ∼50–100 days in the most challenging but still feasible cases, such as an Earth twin at 5 pc. A few cases with very low fluxes around specific host stars are not detectable. In summary, the abundances of these capstone biosignatures are detectable at plausible biological production fluxes for most cases examined and for a significant number of potential targets.
Photoionization of Nitrile-substituted Naphthalene and Benzene: Cation Spectroscopy, Photostability, and Implications for Photoelectric Gas Heating
Authors: Roy Chowdhury Madhusree , Garcia Gustavo A. , Hrodmarsson Helgi R. , Loison Jean-Christophe , Nahon Laurent 
Published: February 2024

Abstract
We investigate the vacuum ultraviolet (VUV) photodynamics of gas phase 1- and 2-cyanonaphthalene and cyanobenzene, recently detected in the Taurus molecular cloud, by combining synchrotron radiation and a double imaging electron/ion coincidence setup. The high-resolution threshold photoelectron spectra (TPES) of all three molecules are obtained experimentally from which the adiabatic ionization energies are reported with very high accuracy, particularly for 2-cyanonaphthalene, for which no data exist at this level of precision. Theoretical calculations are performed to compare with the TPES for the ground electronic state of the cations. Furthermore, the different features observed in the extended TPES have been assigned to the different molecular orbitals with the help of the outer valence Green's function calculations. The present experiments also shed light on the kinetic energy distribution of the photoelectrons as a function of the incident photon energy, to describe their contribution to the photoelectric heating effect in the interstellar medium. In this context, we show how kinetic energy distributions can be obtained from our data for any given photon energy, such as the omnipresent Lyα line, or any given interstellar radiation field (ISRF). In addition, from the total ion yields, we estimate the photorates for a few ISRFs. Finally, we discuss the photodissociation of the two cyanonaphthalenes, quoting the activation energies of the dissociation channels with the help of Rice–Ramsperger–Kassel–Marcus modeling. It is observed that CN substitution does not cause any appreciable change to the VUV dissociative photoionization relaxation channel.
Inferring the Redshift of More than 150 GRBs with a Machine-learning Ensemble Model
Authors: Dainotti Maria Giovanna , Taira Elias , Wang Eric , Lehman Elias , Narendra Aditya , Pollo Agnieszka , Madejski Grzegorz M. , Petrosian Vahe , Bogdan Malgorzata , Dey Apratim , Bhardwaj Shubham 
Published: February 2024

Abstract
Gamma-ray bursts (GRBs), due to their high luminosities, are detected up to a redshift of 10, and thus have the potential to be vital cosmological probes of early processes in the Universe. Fulfilling this potential requires a large sample of GRBs with known redshifts, but due to observational limitations, only 11% have known redshifts (z). There have been numerous attempts to estimate redshifts via correlation studies, most of which have led to inaccurate predictions. To overcome this, we estimated GRB redshift via an ensemble-supervised machine-learning (ML) model that uses X-ray afterglows of long-duration GRBs observed by the Neil Gehrels Swift Observatory. The estimated redshifts are strongly correlated (a Pearson coefficient of 0.93) and have an rms error, namely, the square root of the average squared error 〈Δz
2〉, of 0.46 with the observed redshifts showing the reliability of this method. The addition of GRB afterglow parameters improves the predictions considerably by 63% compared to previous results in peer-reviewed literature. Finally, we use our ML model to infer the redshifts of 154 GRBs, which increase the known redshifts of long GRBs with plateaus by 94%, a significant milestone for enhancing GRB population studies that require large samples with redshift.
Relations of Rotation and Chromospheric Activity to Stellar Age for FGK Dwarfs from Kepler and LAMOST
Authors: Ye Lifei , Bi Shaolan , Zhang Jinghua , Sun Tiancheng , Long Liu , Ge Zhishuai , Li Tanda , Zhang Xianfei , Chen Xunzhou , Li Yaguang , Zhou Jianzhao , Xiang Maosheng 
Published: February 2024

Abstract
The empirical relations between rotation period, chromospheric activity, and age can be used to estimate stellar age. To calibrate these relations, we present a catalog, including the masses and ages of 52,321 FGK dwarfs, 47,489 chromospheric activity index

log

R

HK

+

, 6077 rotation periods P
rot, and variability amplitudes S
ph, based on data from LAMOST DR7, Kepler, and Gaia Data Release 3. We find a pronounced correlation among P
rot, age, and [Fe/H] throughout the main-sequence phase for F dwarfs. However, the decrease of

log

R

HK

+

over time is not significant except for those with [Fe/H] < −0.1. For G dwarfs, both P
rot and

log

R

HK

+

are reliable age probes in the ranges ∼2–11 Gyr and ∼2–13 Gyr, respectively. K dwarfs exhibit a prominent decrease in

log

R

HK

+

within the age range of ∼3–13 Gyr when the relation of P
rot–τ is invalid. These relations are very important for promptly estimating the age of a vast number of stars, thus serving as a powerful tool in advancing the fields of exoplanet properties, stellar evolution, and Galactic archeology.
Roaring to Softly Whispering: X-Ray Emission after ∼3.7 yr at the Location of the Transient AT2018cow and Implications for Accretion-powered Scenarios*
Authors: Migliori Giulia , Margutti R. , Metzger B. D. , Chornock R. , Vignali C. , Brethauer D. , Coppejans D. L. , Maccarone T. , Rivera Sandoval L. , Bright J. S. , Laskar T. , Milisavljevic D. , Berger E. , Nayana A. J. 
Published: February 2024

Abstract
We present the first deep X-ray observations of luminous fast blue optical transient (LFBOT) AT 2018cow at ∼3.7 yr since discovery, together with the reanalysis of the observation at δ
t ∼ 220 days. X-ray emission is significantly detected at a location consistent with AT 2018cow. The very soft X-ray spectrum and sustained luminosity are distinct from the spectral and temporal behavior of the LFBOT in the first ∼100 days and would possibly signal the emergence of a new emission component, although a robust association with AT 2018cow can only be claimed at δ
t ∼ 220 days, while at δ
t ∼ 1350 days contamination of the host galaxy cannot be excluded. We interpret these findings in the context of the late-time panchromatic emission from AT 2018cow, which includes the detection of persistent, slowly fading UV emission with ν
L

ν
≈ 1039 erg s−1. Similar to previous works (and in analogy with arguments for ultraluminous X-ray sources), these late-time observations are consistent with thin disks around intermediate-mass black holes (with M
• ≈ 103–104
M
☉) accreting at sub-Eddington rates. However, differently from previous studies, we find that smaller-mass black holes with M
• ≈ 10–100 M
☉ accreting at ≳the Eddington rate cannot be ruled out and provide a natural explanation for the inferred compact size (R
out ≈ 40 R
☉) of the accretion disk years after the optical flare. Most importantly, irrespective of the accretor mass, our study lends support to the hypothesis that LFBOTs are accretion-powered phenomena and that, specifically, LFBOTs constitute electromagnetic manifestations of super-Eddington accreting systems that evolve to ≲Eddington over a ≈100-day timescale.
High Dynamic Range Image Processing for Retinal Color Fundus Photography
Authors: Critser D. Brice , Troyer Jody , Whitmore S. Scott , Mansoor Mahsaw , Stone Edwin M. , Russell Jonathan F. , Han Ian C. 
Published: February 2024

Background and Objective:
Color fundus photography is an important imaging modality that is currently limited by a narrow dynamic range. We describe a post-image processing technique to generate high dynamic range (HDR) retinal images with enhanced detail.

Patients and Methods:
This was a retrospective, observational case series evaluating fundus photographs of patients with macular pathology. Photographs were acquired with three or more exposure values using a commercially available camera (Topcon 50-DX). Images were aligned and imported into HDR processing software (Photomatix Pro). Fundus detail was compared between HDR and raw photographs.

Results:
Sixteen eyes from 10 patients (5 male, 5 female; mean age 59.4 years) were analyzed. Clinician graders preferred the HDR image 91.7% of the time (44/48 image comparisons), with good grader agreement (81.3%, 13/16 eyes).

Conclusions:
HDR fundus imaging is feasible using images from existing fundus cameras and may be useful for enhanced visualization of retinal detail in a variety of pathologic states.

[
Ophthalmic Surg Lasers Imaging Retina
2024;55:263–269.]
Fernand Deligny, enfant et institution
Authors: Pouteyo Michaël 
Published: February 2024

Alors que le XIXe siècle met l’enfant à l’école, la première moitié du XXe s’occupe de celui qui n’y va pas. Qu’on le dise arriéré, délinquant, orphelin, fou ou en danger moral, l’enfant en marge voit se développer autour de lui un édifice institutionnel qui, entre le début du siècle et la fin des années soixante, acquiert progressivement consistance matérielle et unification idéologique.
C’est en examinant le parcours et le travail de Fernand Deligny (1913-1996), instituteur, éducateur et écrivain, que cet ouvrage entend redessiner cette histoire. Sans se limiter aux innovations législatives qui jalonnent la période ou aux acteurs qui font figure de fondateurs, il entend éclairer les évolutions idéologiques qui sous-tendent ce développement. En revenant sur les alliances, les oppositions et les affrontements auxquels se livrent les principaux personnages de cette période, cette enquête philosophique vise à mieux situer la place de Deligny, et à donner un autre éclairage à deux concepts au cœur de cette histoire : l’institution et l’enfant.
Predictors of Pregnancy Disclosure in National Collegiate Athletic Association Division III Athletes
Authors: Horn Kiley E. , Harris Tyler S. 
Published: February 2024

Context
Pregnant athletes cannot receive proper care if they choose to conceal their pregnancy. Unfortunately, many factors may lead an athlete to conceal. Whereas the extant qualitative literature suggests scholarship and sponsorship are prominent factors in the decision to disclose, this research is limited to elite athletes.

Objective
To quantitatively examine predictors of pregnancy disclosure beyond scholarship and sponsorship in National Collegiate Athletic Association Division III college athletes.

Design
Cross-sectional study.

Setting
Midwestern United States.

Participants or Other Participants
Athletes on Division III women’s sports teams (N = 127).

Main Outcome Measure(s)
Confidence in the athletic trainer (AT), perceived training and performance changes, athletic identity, and athletic identity during pregnancy. Two separate multiple regression analyses were conducted with the 4 predictors and 2 outcomes: likelihood to disclose and time to disclosure.

Results
Confidence in the AT and athletic identity during pregnancy were significant predictors in both models, whereas the variable of perceived training and performance changes was only significant in the likelihood to disclose model. Athletic identity was not a significant predictor in either model. Results suggest Division III athletes believe they would be more likely to disclose their pregnancy and may disclose sooner if they feel that their AT can properly manage their physical, emotional, and social wellness during the pregnancy. Additionally, disclosure is promoted if they believe they will still be viewed as athletes by themselves and the people around them.

Conclusions
These findings emphasize the importance of the role of the AT, with implications that formal education of ATs should include the holistic support of the pregnant athlete.
A tale of two towns: Water provision and management in the towns of Beaufort West and Vanrhynsdorp, c. 1900–1970
Authors: Visser Wessel P. , Rademan Daniel R. 
Published: February 2024

The Karoo region of South Africa receives some of the lowest annual precipitation in South Africa. The towns of Beaufort West and Vanrhynsdorp share a history of unreliable water supplies, coupled with extreme poverty that left a large section of the population of these towns with little to no access to safe water and sanitation infrastructure. Vanrhynsdorp and Beaufort West had low populations and limited permanent infrastructure during the 19th century. As the 20th century progressed, agricultural market price drops, droughts, the opening of railway lines and the promise of better living conditions spurred on by local business pushed larger numbers of people towards the rural towns. This led to the rapid expansion of populations in rural towns that lacked the financial and practical means to accommodate the rising need for larger permanent water sources and supply infrastructure (often in the form of groundwater). This article will compare how Beaufort West and Vanrhynsdorp developed divergent water provision systems between 1900 and 1970. These two case studies represent a glimpse into the history of water provision struggles of towns in the arid interior during the first half of the 20th century.Contribution: This article focusses on South African water history, and specifically on the problematics of water procurement to towns and communities in the arid Karoo region amid failing water infrastructure and recurring droughts. It augments the historical knowledge on strategies to provide water to rural communities under conditions of duress. The article falls within the scope of New Contree’s scientific focus as it throws more light on the historical infrastructure challenges that two rural communities faced and what strategies they have implemented to overcome such challenges.
Comparing Points in Target Range Assessed by Blood Glucose Monitoring Using a Vacuum-based Lancing Device and Conventional Lancing Devices
Authors: Kesavadev Jothydev , Shankar Arun , Basanth Anjana , Krishnan G. Gopika , Sreelaksmi R. , Gopika Beena Chandran , Jothydev Sunitha 
Published: February 2024

Background:
Time-in-range, the recently introduced metric is effective with CGM devices. Several reasons such as inaccessibility, out-of-pocket expense etc. challenge the wider acceptance of CGM devices globally. In this scenario a similar metric termed point-in-range (PIR) was introduced which can be calculated based on the frequent readings from blood glucose meters.

Aim:
The current study aims to compare the points in range in people with type 1 diabetes and type 2 diabetes using Genteel, a commercially available lancer that applies vacuum after lancing and a non-vacuum conventional lancing device.

Methods:
Data for the study was retrieved from an open-label, 24-week cross-over trial and analyzed retrospectively. The cohort included both patients with type 1 diabetes (n=58; age= 17.70 ± 10.18) and type 2 diabetes. The participants used Genteel for 12 weeks and then switched to a conventional lancing device for additional 12 weeks or vice versa. PIR was calculated and compared when using a Genteel and using a conventional lancer. Statistical analysis was carried out using SPSS software, version 16, and a significance threshold of P<0.05 was used.

Results:
Selected individuals with T1D, showed significantly higher frequency of blood glucose level falling within the range and significantly lower frequency of blood glucose level falling above range (PAR) while using Genteel in comparison to the conventional lancing devices. In addition, a significant reduction in HbA1c levels (from 8.94 ± 1.77% to 8.25 ± 1.67%) was observed among the subjects with T1D who used the Genteel device. No change in the frequency of blood glucose level falling within the range was observed in patients with type 2 diabetes.

Conclusion:
Painless glucose monitoring facilitated by Genteel may have contributed to the increased monitoring frequency which in turn contributed to higher PIR, lower PAR and significant reduction in the HbA1c.
Replacement of Ascending Aortic Aneurysm with Anomalous Origin of the Right Coronary Artery: Multidisciplinary Imaging for the Diagnosis
Authors: Ceresa Fabrizio , Micari Antonio , Mammana Liborio Francesco , Maisano Umberto , Carlo Alessandro Di , Luongo Alfredo , Patanè Francesco 
Published: February 2024

Abstract
This case report presents a rare scenario involving a congenital anomaly of the right coronary artery’s (RCA) origin in association with an ascending aortic aneurysm. While both anomalies are individually recognized in the literature, their coexistence and potential interplay remain understudied. The aim of this report is to emphasize the challenges and implications associated with such a combination. A 78-year-old male patient with an enlarged ascending aortic aneurysm necessitating surgical intervention was found to have an anomalous origin of the RCA during preoperative coronary angiography, confirmed by computed tomography scan. Transesophageal echocardiography further elucidated the coronary abnormality. Intraoperatively, successful aortic replacement was performed, and careful repositioning of the anomalous right coronary ostium was achieved. This case raises important considerations regarding the potential complications arising from coronary anomalies and their impact on the surgical management of ascending aortic aneurysms. The rarity of this combination limits our understanding of their association, making a multidisciplinary approach crucial for optimal patient care. Further research and comprehensive evaluation of similar cases are necessary to better understand the relationship between coronary anomalies and ascending aortic aneurysms. Such investigations will help in improving treatment strategies and outcomes for patients with these complex conditions.
There is Nothing More Invisible than the Obvious: A Case Summary and Literature Review
Authors: Alfieri Michele , Ianni Umberto , Molisana Michela , Parato Vito Maurizio 
Published: February 2024

Abstract
Bioprosthetic valvular failure (BVF) is a pathological entity arising from a variety of conditions affecting prosthetic heart valves. It may present with an extremely varied pattern, and the identification of the exact etiology is vital to provide a prompt and adequate treatment. It is established that infective endocarditis mainly affects patients with intracardiac devices such as pacemakers or prosthetic valves, and it represents one of the principal mechanisms of BVF. Despite its high incidence, clinical presentations may be atypical, and a close monitoring is essential to prevent catastrophic consequences. We present the case of a partial valvular bioprosthesis detachment associated with a newly formed pseudoaneurysm due to a late infective endocarditis occurred after cardiac surgery, initially manifested with negative blood cultures and clinical findings. We also try to set up a literature review of the most common causes of valvular failure and pseudoaneurysm formation.