bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rapid superselective high‐dose cisplatin infusion for advanced head and neck malignancies
Authors: Robbins K. Thomas , Storniolo A. M. , Kerber Charles , Seagren Stephen , Berson Anthony , Howell Stephen B. 
Published: February 2007

AbstractAdvances in vascular radiology techniques for superselective arterial infusions and methods to overcome systemic toxicity from high‐dose cisplatin chemotherapy encouraged us to re‐evaluate the effects of rapid regional cisplatin infusion for patients with head and neck malignancies. Twenty patients (17 carcinomas, three sarcomas) received high‐dose cisplatin (100‐200 mg/m2) by this method. Fifteen of the 17 patients with upper aerodigestive tract carcinoma are part of an ongoing phase I dose escalation of cisplatin with sodium thiosulfate neutralization. Three additional patients with sarcomas were treated with intra‐arterial (IA) cisplatin and systemic Adriamycin. Fifty‐three IA infusions were performed without any complications. Only minimal toxicity related to the chemotherapy was observed. The overall response rate for previously untreated patients was nine of 10 (90%) [complete response (CR) 67%; partial response (PR) 33%]. The response rate for patients with recurrent disease was five of eight (63%) (CR 20%, PR 80%). The average length of follow‐up is 9.5 months and the actuarial survival rate is 56%. Superselective rapid infusion of high‐dose cisplatin for patients with advanced head and neck malignancies is feasible, relatively nontoxic, and may have important applications in multimodality therapy, particularly for patients with bulky primary disease. © 1992 John Wiley & Sons, Inc.
Embolization of a life‐threatening mandibular vascular malformation by direct percutaneous transmandibular puncture
Authors: Resnick Scott A. , Russell Eric J. , Hanson David H. , Pecaro Bernard C. 
Published: February 2007

AbstractVascular malformations of the mandible are uncommon, but often present with significant hemorrhage. Transarterial vessel occlusion has become a valuable primary or adjunctive treatment for such lesions, as well as for most other symptomatic congenital and acquired head and neck vascular anomalies. Permanent embolic obliteration of the malformation requires placement of occlusive material directly into the nidus (core) of the lesion. Prohibitively complex proximal vasculature may prevent successful catheter positioning and lead to failure of traditional embolotherapy. Even optimal placement of arterial embolic material may fail to fully obliterate the nidus, allowing eventual restoration of flow to the lesion due to arterial recanalization. Under such circumstances it may be possible to obliterate the malformation and control lesional hemorrhage by occlusion of the malformation or its venous drainage by direct percutaneous mandibular puncture. In our case, multiple transarterial embolizations failed to sufficiently manage a symptomatic vascular malformation. Successful embolotherapy was performed via direct puncture of the venous side of the malformation through the mandibular cortex. Venous thrombosis induced concomitant occlusion of abnormal arteriovenous shunts, resulting in long‐term control of life‐threatening oral hemorrhage. © 1992 John Wiley & Sons, Inc.
Surgical anatomy of the external branch of the superior laryngeal nerve
Authors: Cernea Claudio R. , Ferraz Alberto R. , Nishio Sunao , Dutra Augusto , Hojaij Flavio C. , Dos Santos Luiz R. Medina 
Published: February 2007

AbstractIatrogenic lesions of the external branch of the superior laryngeal nerve (EBSLN) during thyroidectomies are not infrequent due to the possibility of anatomic variations of the relationships of this nerve with the superior thyroid vessels. Therefore, based on an anatomic analysis of 30 superior thyroid poles from 15 fresh cadavers, a new classification of the EBSLN was proposed, considering the jeopardy during a thyroidectomy. Thirty‐seven percent of the nerves were type 2, ie, crossing the superior thyroid pedicle less than 1 cm above the superior thyroid pole. It is notable that 20% were type 2b, ie, crossing the vessels below the upper border of the pole, having been considered “high risk.” This incidence was comparable with other series, which found dangerous anatomic variations of the EBSLN in the range of 15% to 68%, confirming that a significant proportion of these nerves might be at risk during surgery on the superior thyroid pole. © 1992 John Wiley & Sons, Inc.
Overexpression of P53 in head and neck cancer
Authors: Watling David L. , Gown Allen M. , Coltrera Marc D. 
Published: February 2007

AbstractThe putative tumor suppressor gene p53 plays a key role in the regulation of cell proliferation. Functional loss of p53 protein through mutation or viral oncogene‐complexing can result in p53 protein overexpression detectable by immunocytochemistry, which in turn has been associated with markers of poor prognosis in some cancers. We report here an analysis of p53 overexpression in fixed, embedded specimens from 81 prospectively collected head and neck tumors, both benign and malignant, including 55 squamous cell carcinomas, using monoclonal pAb1801. Sixty‐two percent of the squamous cell carcinomas from the head and neck region overexpressed p53, whereas none of the benign tumors or adjacent normal tissues overexpressed p53. Overexpression of p53 was strongly associated (p < 0.01, two‐tailed chi‐square) with a histologic malignancy grading scale previously shown to have prognostic capabilities. We conclude that p53 overexpression is one of the most common abnormalities identified in head and neck cancer, and may be a useful marker in the study of multistep progression of tumori‐genesis. © 1992 John Wiley & Sons, Inc.
DNA ploidy analysis of squamous cell head and neck cancer to identify distant metastasis from second primary
Authors: Slootweg Pieter J. , Rutgers Derk H. , Wils Iris S. 
Published: February 2007

AbstractWe conducted an investigation by flow cytometry to determine whether lung cancer in eight patients with oral cancer represented a metastasis or a second primary. One patient had the same aneuploid cell population at both sites which indicated the lung lesion to be a metastasis. Two patients had a diploid lesion at both sites. In these patients, a second primary could not be distinguished from a distant metastasis because (notwithstanding both lesions being diploid) the tumors may have a different DNA content but at a level too low for flow cytometric detection. Five cases had differing DNA indices, which could represent a second primary as well as the emergence of a new clone during tumor progression and metastasis. It appears that DNA flow cytometry can identify tumors that are the same if both have the same aneuploid pattern, but it cannot prove that they are different. © 1992 John Wiley & Sons, Inc.
Pathogenesis and surgical treatment of migraine and neurovascular headaches with rhinogenic trigger
Authors: Novak V. Josef , Makek Miro 
Published: February 2007

AbstractPatients (299) with various types of headaches (migraines, cluster headaches, and so‐called idiopathic headaches) were operated on between 1973 and 1991. Septal correction, resection of the middle concha, ethmoidectomy, and sphenoidectomy on the corresponding headache side or occasionally on both sides were carried out. Most patients (235; 78.5%) were totally asymptomatic postoperatively; 34 (11.5%) had a sensation of pressure in the head on rare occasions but no further migraines, and 30 (11%) continued to experience headaches that occurred only rarely and were mild and of short duration. © 1992 John Wiley & Sons, Inc.
Thoracic duct cyst: An unusual supraclavicular mass
Authors: Wax Mark K. , Treloar Murray E. 
Published: February 2007

AbstractLesions of the thoracic duct may occur either in the neck or the mediastinum. The majority of lesions that present in the neck consist of chylous fistulae and are secondary to neck surgery. Cysts of the thoracic duct are very rare and are usually reported as a disease entity of the mediastinum. There are only two reported cases in the literature of thoracic duct cysts occurring in the neck. The third case of a thoracic duct cyst located primarily in the neck is reported. Thoracic duct cysts in the neck must be differentiated from other cysts of the neck, because not recognizing the inferior attachment to the thoracic duct, may result in the disastrous consequence of a chylothorax. Diagnosis can easily be made by fine‐needle aspiration with biochemical analysis. Computerized axial tomography (CAT) is useful in defining the anatomic boundaries. A weakness in the wall of the thoracic duct, either on a congenital or degenerative basis, has been postulated as the etiology. The natural history of these lesions remains unknown. Smaller lesions may be followed at routine intervals. Larger lesions should be surgically removed because of the possible complications that may ensue as a result of traumatic rupture or inflammation. © 1992 John Wiley & Sons, Inc.
Cytokeratin expression in normal and (pre)malignant head and neck epithelia: An overview
Authors: Van Der Velden Lilly‐Ann , Schaafsma H. Ewout , Manni Johannes J. , Ramaekers Frans C. S. , Kuijpers Wim 
Published: February 2007

AbstractIntermediate filament proteins (IFPs) are important markers of tissue differentiation and have been receiving increasing interest, in particular, through their applicability in the characterization of malignant tumors. Cytokeratins (Cks) are a family of IFPs that are typically specific for epithelial cells. They are expressed in certain combinations depending on the type of epithelium and the degree of differentiation. This review presents a critical analysis of the available data on Ck expression in normal and (pre) neoplastic epithelia of the head and neck region. Special attention is paid to technical and cell biologic pitfalls, which can lead to false‐negative or false‐positive data. It appears that only a limited fraction of the reported data contributes substantially to our knowledge of IFP expression in head and neck cancer because of the use of ill‐defined, often formalin‐fixed and paraffinembedded, tissue specimens, and the application of limited panels of monoclonal antibodies. It is concluded that the use of immunocytohistochemistry is promising for the differential diagnosis of head and neck tumors and contributes to our knowledge on their biologic behavior. However, documentations of more complete Ck expression patterns of normal and (pre)malignant epithelium are required, together with their correlation to clinical parameters.
Combined approach for excision of cervical nerve tumors with dural extension
Authors: Komisar Arnold , Blaugrund Stanley M. , Camins Martin , Mangiardi John 
Published: February 2007

AbstractTumors of the cervical plexus are rare. Often these tumors are found on routine exam as asymptomatic masses. We present our experience in managing four patients with tumors with dural extension. Three of these lesions were neurilemomas and one was a meningioma. Symptoms and signs included weakness and hypoesthesia. Evaluation included complete neurologic examination with electromyography (EMG). Magnetic resonance imaging (MRI) was the best diagnostic tool to see tumor extent into the epidural and intradural space. Computed tumography (CT) or plain x‐rays were used to evalute the degree of destruction of the cervical spine. The surgical removal of these tumors was performed by a two‐team approach. A posterior laminectomy was xcombined with an anterior neck exploration. Follow‐up shows persistent upper extremity weakness in two patients, hypesthesia in three patients, and anesthesia of the anterior chest wall in two patients. Patients with these lesions should be informed of the potential neurologic consequences of removal.
Correlation between nodal density in contrasted scans and response to cisplatin‐based chemotherapy in head and neck squamous cell cancer: A prospective validation
Authors: Janot François , Cvitkovic Esteban , Piekarski Jean Daniel , Sigal Robert , Armand Jean Pierre , Bensmaine Amine , Luboinski Bernard 
Published: February 2007

AbstractThis prospective study was done to validate an earlier retrospective study demonstrating a relationship between complete response to chemotherapy and nodal density as estimated in contrasted computed tumorgraphy (CT scans) in head and neck squamous cell carcinoma (HNSCC). CT scans of 36 patients were evaluated by two radiologists blinded to therapeutic outcome. The density of the largest node (>2 cm) was compared to that of nuchal muscles. A node was classified as hypodense if more than 33% of the nodal surface area consisted of hypodense zones. Density and nodal staging were related: 67% (10 of 15) of patients with N3 disease but only 29% (six of 21) with N1–N2 exhibited isodensity, p < 0.05. Complete response to chemotherapy was noted in 63% (10 of 16) of the isodense group but only in 15% (three of 20) of the hypodense group, p < 0.01. We believe that nodal density can be used for therapeutic decision‐making in high nodal volume HNSCC.
Hyperbaric oxygen therapy and squamous cell carcinoma cell line growth
Authors: Sklizovic Davor , Sanger James R. , Kindwall Eric P. , Fink John G. , Grunert Brad K. , Campbell Bruce H. 
Published: February 2007

AbstractHyperbaric oxygen (HBO) promotes tissue healing by increasing oxygenation. Therefore, HBO therapy is clinically useful for some patients who have undergone major cancer resection and/or radiotherapy to the head and neck. For individual patients, however, there might be undetected viable tumor present at the time of therapy. This study was performed to determine if increased tissue oxygen had a measurable effect on the growth of squamous carcinoma xenotransplants which had been derived from head and neck cancers. After the successful growth of two well‐established human squamous cell carcinoma cell lines (183 and 1483), each tumor was transplanted into 20 mice. Every mouse received four transplants of 106 cells. Ten mice with 40 xenotransplants in each group were treated with HBO daily for 90 minutes at a pressure of 2 atm, whereas the other 10 formed the control group. The mice transplanted with cell line 1483 were treated for 21 days; mice transplanted with cell line 183 were treated for 28 days. The tumor weight, volume, and histology were evaluated. No significant difference was found between experimental groups. This study suggests that increased tissue oxygen neither significantly increases nor decreases the growth of squamous cell carcinoma.
Neoplastic seeding of squamous cell carcinoma of the oropharynx
Authors: Clayman Gary , Cohen James I. , Adams George L. 
Published: February 2007

AbstractNeoplastic seeding is a concept of mechanical disruption and spread of tumor into normal tissues. It is well‐documented and accepted as an explanation for unusual patterns of tumor recurrence at multiple sites in the body. Neoplastic seeding is often invoked as an explanation for stomal recurrences following treatment of laryngeal carcinoma. However, it is impossible to discern whether these recurrences represent peritracheal lymph nodes, persistent or recurrent local disease, or neoplastic seeding of tumor. The purpose of this article is to report two cases of tracheostomy site recurrences after treatment of oropharyngeal squamous carcinoma, in which neoplastic seeding is the most plausible explanation of recurrence. The rarity of this phenomenon appears strikingly small despite significant experimental evidence supporting the possibility of its occurrence. Although specific recommendations for prevention cannot be made, it appears prudent to avoid re‐use of instruments that come into direct contact with squamous cell carcinoma tumor surface.
Manifestations of metastatic breast carcinoma to the head and neck
Authors: Wanamaker John R. , Kraus Dennis H. , Eliachar Isaac , Lavertu Pierre 
Published: February 2007

AbstractAlthough metastatic neoplasms in the head and neck are rare compared to primary head and neck neoplasms, metastatic breast carcinoma has been described at numerous sites in the head and neck region. Two cases of breast carcinoma metastatic to sites in the head and neck are reported. In one case a laryngeal metastasis represented the first manifestation of recurrent breast cancer. The second case, a nasal metastasis, was unsuspected and was treated as cellulitis. The presentation of metastatic breast carcinoma to the head and neck may in fact be atypical, posing a diagnostic dilemma. These cases illustrate the importance of past medical history and the high index of suspicion in patients with a history of prior malignancy.
Treatment of stage I and II oral tongue cancer
Authors: Lydiatt Daniel D. , Robbins K. Thomas , Byers Robert M. , Wolf Patricia F. 
Published: February 2007

AbstractWe reviewed 156 previously untreated patients with squamous cell carcinoma of the oral tongue staged T1 and T2 to determine the incidence of nodal metastasis, and if elective neck dissection affected local/regional control or survival. Patients were divided into two nonrandomized groups: group 1, intraoral glossectomy only (102 patients); and group 2, intraoral glossectomy plus neck dissection (54 patients). Analysis revealed no significant differences for tumor location, histologic differentiation, status of margins, or clinical appearance; however, perineural invasion significantly adversely affected survival and local/regional control. In group 1 patients, 16.5% subsequently developed cervical metastasis, and 20.4% of patients in group 2 had occult nodal disease. The survival and local/regional control for group 1 patients subsequently developing nodes was 33% and 50%, respectively. The survival and local/regional control for group 2 patients with occult metastasis was 55% and 91%, respectively. We believe elective neck dissection is indicated for early staged oral tongue cancer.
Effects of maneuvers on swallowing function in a dysphagic oral cancer patient
Authors: Lazarus Cathy , Logemann Jeri A. , Gibbons Patricia 
Published: February 2007

AbstractThis study examined the effects of three swallow maneuvers: (1) the supraglottic swallow (voluntary closure of the vocal folds prior to the swallow); (2) the super‐supraglottic swallow (airway closure at the level of the arytenoid to base of epiglottis); and (3) the Mendelsohn maneuver (voluntary prolongation of laryngeal elevation and cricopharyngeal opening during swallow) on swallow functioning in a 47‐year‐old patient who underwent right composite resection for a squamous cell carcinoma of the right retromolar trigone. All maneuvers were employed during the same videofluorographic (VFG) swallow study conducted 6 months after the patient's surgery. Biomechanical analysis of 3‐mL swallows defined the extent and timing of tongue base retraction to the posterior pharyngeal wall, laryngeal elevation, laryngeal closure and cricopharyngeal opening during swallows with and without maneuvers. Airway closure duration was prolonged during supraglottic and super‐supraglottic swallows, but aspiration was not eliminated. Use of the Mendelsohn maneuver improved coordination and timing of pharyngeal swallow events, including timing of posterior movement of the tongue base to the pharyngeal wall in relation to airway closure and cricopharyngeal opening, with elimination of aspiration. The Mendelsohn maneuver compensated for anatomic and physiologic changes in the oropharyngeal swallow and enabled reinstatement of safe oral intake in this surgically treated head and neck cancer patient who was previously unable to take nutrition orally.
Platysma myocutaneous flap for head and neck reconstruction in cats
Authors: Smith Mark M. , Shults Stacey , Waldron Don R. , Moon Martha L. 
Published: February 2007

AbstractSquamous cell carcinoma is the fourth most common neoplasm in cats. As in man, local resective surgery of stage III and IV carcinoma often results in recurrence related to compromised margins. Radical resective procedures may be performed when reconstructive techniques are available to restore cosmesis and function. A platysma myocutaneous flap that was based on a cutaneous branch of the caudal auricular artery and vein was developed to fulfill this requirement. Control flaps, which included ligation and division of the caudal auricular artery and vein, were similarly developed on the contralateral aspect of the neck. Mean survival of all platysma myocutaneous flaps (86.7%), compared with control flaps (62.9%), was significantly different (p< .05). Flaps grouped in lengths of 6, 9, and 12 cm had mean survival lengths of 93.8%, 81.9%, and 84.4%, respectively. The mean survival length of flaps measuring 12 cm in length was significantly different (p< .05) compared with flaps measuring 6 and 9 cm. On the basis of the results of this study, the platysma myocutaneous flap based on a cutaneous branch of the caudal auricular artery and vein may be a source of tissue for reconstructive procedures of the head and neck in cats.
Mesenchymal chondrosarcoma of the jaw—report of a case and review of 41 cases in the literature
Authors: Takahashi Kikuo , Sato Kenichi , Kanazawa Harusachi , Wang Xiao‐Li , Kimura Takayuki 
Published: February 2007

AbstractA case of mesenchymal chondrosarcoma in the mandible of a 35‐year‐old woman is presented. In a thorough survey of the world literature, 41 cases of mesenchymal chondrosarcoma occurring the jaw are reviewed.
Controversies: Carcinoma of the tonsil
Authors: Snyderman Nancy L. , Strome Marshall , Ward Paul , Johnson Jonas , Goepfert Helmuth 
Published: February 2007

AbstractEditor's note: One of the most interesting aspects of this job is that the contributors never fail to surprise me. When I submit what I consider a straightforward case, I commonly receive quite complex and circuitous answers. Conversely, cases that could be treated in a variety of ways may come back with a consensus. Responses in this case lived up to my unexpected expectations. Health care costs in the United States are skyrocketing. Health care providers now grapple with economic decisions that in years past would have been inconceivable. We also face the stark realization that health care in this country is now rationed. Not everyone gets it. In the opinion of this editor, as we attempt to deal with health care costs in the future, harder decisions will have to be made. If a patient develops cancer after years of smoking or cirrhosis after years of abusing alcohol, who should be responsible for the costs of treatment? Does secondhand smoke play a role in the genesis of head and neck cancers? Should a patient's home life alter treatment plans? Should economics be considered? Who will make the decisions? The answers are complex. What I thought would be long and conflicting thoughts from the experts turned out to be short and to the point–another surprise.