bluuebunny/crossref_metadata_2025_split huggingface dataset:
First-in-human Phase I Trial of TPST-1120, an Inhibitor of PPARα, as Monotherapy or in Combination with Nivolumab, in Patients with Advanced Solid Tumors
Authors: Yarchoan Mark , Powderly John D. , Bastos Bruno R. , Karasic Thomas B. , Crysler Oxana V. , Munster Pamela N. , McKean Meredith A. , Emens Leisha A. , Saenger Yvonne M. , Ged Yasser , Stagg Robert , Smith Steven , Whiting Chan C. , Moon Anne , Prasit Peppi , Jenkins Yonchu , Standifer Nathan , Dubensky Thomas W. , Whiting Sam H. , Ulahannan Susanna V. 
Published: March 2024

Abstract

Purpose:
TPST-1120 is a first-in-class oral inhibitor of peroxisome proliferator-activated receptor α (PPARα), a fatty acid ligand-activated transcription factor that regulates genes involved in fatty acid oxidation, angiogenesis, and inflammation, and is a novel target for cancer therapy. TPST-1120 displayed antitumor activity in xenograft models and synergistic tumor reduction in syngeneic tumor models when combined with anti-PD-1 agents.

Experimental Design:
This phase I, open-label, dose-escalation study (NCT03829436) evaluated TPST-1120 as monotherapy in patients with advanced solid tumors and in combination with nivolumab in patients with renal cell carcinoma (RCC), cholangiocarcinoma (CCA), or hepatocellular carcinoma. Objectives included evaluation of safety, pharmacokinetics, pharmacodynamics, and preliminary antitumor activity (RECIST v1.1).

Results:
A total of 39 patients enrolled with 38 treated (20 monotherapy, 18 combination; median 3 prior lines of therapy). The most common treatment-related adverse events (TRAE) were grade 1–2 nausea, fatigue, and diarrhea. No grade 4–5 TRAEs or dose-limiting toxicities were reported. In the monotherapy group, 53% (10/19) of evaluable patients had a best objective response of stable disease. In the combination group, 3 patients had partial responses, for an objective response rate of 20% (3/15) across all doses and 30% (3/10) at TPST-1120 ≥400 mg twice daily. Responses occurred in 2 patients with RCC, both of whom had previously progressed on anti-PD-1 therapy, and 1 patient with late-line CCA.

Conclusions:
TPST-1120 was well tolerated as monotherapy and in combination with nivolumab and the combination showed preliminary evidence of clinical activity in PD-1 inhibitor refractory and immune compromised cancers.

Significance:
TPST-1120 is a first-in-class oral inhibitor of PPARα, whose roles in metabolic and immune regulation are implicated in tumor proliferation/survival and inhibition of anticancer immunity. This first-in-human study of TPST-1120 alone and in combination with nivolumab supports proof-of-concept of PPARα inhibition as a target of therapeutic intervention in solid tumors.
Stability and variation of brain-behavior correlation patterns across measures of social support
Authors: Merritt Haily , Faskowitz Joshua , Gonzalez Marlen Z. , Betzel Richard F. 
Published: March 2024

Abstract
The social environment has a critical influence on human development, cognition, and health. Research in health psychology and social neuroscience indicate an urgent need to understand how social relationships are associated with brain function and organization. To address this, we apply multilayer modeling and modularity maximization—both established tools in network neuroscience—to jointly cluster patterns of brain-behavior associations for seven social support measures. By using network approaches to map and analyze the connectivity between all pairs of brain regions simultaneously, we can clarify how relationships between brain regions (e.g. connectivity) change as a function of social relationships. This multilayer approach enables direct comparison of brain-behavior associations across social contexts for all brain regions and builds on both ecological and developmental neuroscientific findings and network neuroscientific approaches. In particular, we find that subcortical and control systems are especially sensitive to different constructs of perceived social support. Network nodes in these systems are highly flexible; their community affiliations, which reflect groups of nodes with similar patterns of brain-behavior associations, differ across social support measures. Additionally, our application of multilayer modeling to patterns of brain-behavior correlations, as opposed to just functional connectivity, represents an innovation in how multilayer models are used in human neuroscience. More than that, it offers a generalizable technique for studying the stability and variation of brain-behavior associations.
Regulating, braking and pushing mechanisms of reindeer (Rangifer tarandus) feet based on center of pressure
Authors: Li Guoyu , Zhang Rui , Pang Hao , Wang Junfeng , Sun Xumin , Li Zhisong , Luo Yexuan , Wen Lige 
Published: March 2024

Abstract
Reindeer are seasonal migratory animals, and their feet play a significant role in braking and pushing. Their natural habitats in arctic regions require them to navigate complex ground conditions, and their feet have evolved to adapt to these challenges. Reindeer must travel long distances to find food and water, which demands high levels of endurance and stamina. The ability of reindeer feet to support their weights and maintain stability over extended periods is crucial to the survival of reindeer. The center of pressure at different speeds (walking, low-speed trotting, and high-speed trotting) was studied using a pressure plate to determine the functions of the dewclaws, medial toes and lateral toes of reindeer. The medial toes and lateral toes were the bearing toes, and the dewclaws played an auxiliary supporting role. The proportions of peak value in the bearing toes and dewclaws were 85.1-9.5% and 2.7-22.9%, respectively. The center-of-pressure trajectories of hindfeet and forefeet were an L-shaped line and a straight line, respectively. The proportion of peak value in forefoot dewclaws (7.0-22.9%) was larger than that of hindfoot dewclaws (2.7-8.2%). The coefficients of variation of forefoot dewclaws increased with rising speed, indicating the forefeet adjusted the pressure according to the motion state. The coefficient of variation of forefoot dewclaws (31.1-73.1%) was larger than that of bearing toes (14.1-40.7%), indicating the dewclaws played a stabilization role. The pressure on the bearing toes of the forefeet, which played a braking role, increased with time during the braking phase. The peak loads on the distal medial toe and the distal lateral toe of hindfeet were both in the pushing phase, which were mainly associated with a pushing role. Hence, the characteristics of reindeer feet are conducive to improving the stabilizing and migrating abilities.
Monotherapy Antibiotic Prophylaxis of Lower Extremity Long Bone Type III Open Fractures
Authors: Robinson Thomas W. , Gautreaux Corinne E. , Lee Yann-Leei L. , Mbaka Maryann , Kinnard Christopher M. , Bright Andrew C. , Williams Ashley Y. , Polite Nathan M. , Capasso Thomas J. , Simmons Jon D. , Butts Charles C. 
Published: March 2024

Gustilo type III open fractures involve extensive soft tissue damage and wound contamination that pose significant infection risks. The historical standard for antibiotic prophylaxis has been cefazolin and gentamicin. We conducted a retrospective cohort study of lower extremity type III open fractures treated with ceftriaxone alone for prophylaxis. Eighty-six patients were identified. Nearly all (98%) were managed with appropriate antibiotics, but only 55 (64%) received prophylaxis within 1 hour. Overall, there were 12 infections. This infection rate was not statistically different than the reported literature (14% vs 19%, P = .20). The infection rate between those who received antibiotics within 1 hour was not statistically different from those who got it beyond 1 hour (15% vs 13%, P = .98). In conclusion, the use of ceftriaxone as monotherapy for antibiotic prophylaxis in lower extremity type III open fractures is not statistically different than the use of historic prophylactic regimens.
Derivation of Growth of Import Demand: A Time Series Analysis  of Less Developed Countries
Authors: Chatterjee Riddhi 
Published: March 2024

In this article, growth of import demand is estimated in a dynamic optimisation framework. Since a conventional micro-theoretic import demand function cannot capture the issue of the growth of import demand, it is derived in a macro-theoretic framework of equilibrium import demand function. Growth rate of import demand in a dynamic optimisation framework (considering utility maximisation problem) has not yet been found in the literature. The main focus of this article is to derive this. It is found that growth rate of imports is the function of the growth of domestic income or expenditure, the growth rate of relative price, which is nothing but the real exchange rate, and productivity of capital. The theoretically derived import growth equation was empirically verified for 35 less developed countries. It is observed that for most of the less developed countries, independent variables are statistically significant with expected sign. JEL Codes: F130, F14
The Rising Financialization of Açaí in the Amazon: Evidence of an Ongoing Process
Authors: Neves Fonseca Rafael , Lima Thiago 
Published: March 2024

The expansion and intensification seen in the production of açaí, a fruit that typically grows in the Amazon, can have undesirable and serious socio-environmental consequences. Based on the premise that financialization in the agrifood sector accelerates processes that destroy the environment, an investigation is carried out into the claim that the supply chain regarding açaí is in the process of being financialized. Due to the absence of literature concerning this subject, this article serves as an exploratory case study with a theoretical base. As a result, primary information was collected as much from field visits as from official sources. These field visits produced semi-structured interviews (both in-person and virtual) and informal conversations with some of the actors involved in the açaí production chain. This article argues that the financialization of açaí is still in its early stages. This is primarily due to the involvement of large, financialized corporations, state support for expanding production, and the development of new products and agro-industrial technology. A ampliação e a intensificação da produção de açaí, um fruto típico da Amazônia, tem gerado consequências socioambientais indesejáveis. Partindo do pressuposto de que a financeirização agroalimentar acelera processos de destruição ecológica, buscamos investigar se a cadeia do açaí está financeirizada. Devido à ausência de literatura a respeito deste tema, realizamos um estudo de caso exploratório e teoricamente orientado. Coletamos informações primárias tanto em fontes oficiais quanto em visitas de campo, por meio de entrevistas semiestruturadas (presenciais e virtuais) e de diálogos informais com alguns dos atores da cadeia produtiva do açaí. Concluímos que a financeirização do açaí está em estágio inicial, principalmente devido à entrada de grandes corporações financeirizadas e ao apoio estatal para a ampliação da produção, para o desenvolvimento de tecnologias agroindustriais e de novos produtos.
Youth mentoring: A new holistic intervention targeting the needs of young persons with acquired brain injury
Authors: Odgaard Lene , Bystrup Mette Ryssel , Nielsen Jørgen Feldbæk , Stabel Henriette Holm 
Published: March 2024

Introduction: Holistic rehabilitation approaches addressing the numerous complex challenges in young persons with acquired brain injury are required. The purpose of this study was to describe and evaluate the holistic person-centered youth mentoring intervention program, which is based on occupational therapy. Methods: Prospectively collected data were extracted from a national clinical quality database ( n = 59). Proportions of young persons receiving different aspects of support and proportions rating the intervention as meaningful were calculated. One-year changes in occupation, work ability, and social interactions were calculated. Results: The young persons most frequently received support for energy management (75%) and structuring of everyday life (61%). Seventy-three percent rated the intervention as meaningful. One year post-inclusion, occupation and work ability had increased by 35% and 58%, respectively, and it had declined by 10% and 26%, respectively. The 1-year increase and decrease in social interactions were less clear (15% and 25%, respectively). One-year changes did not differ between those who entered the program early or late after injury indicating the potential beneficial effect of the program. Conclusion: The findings could indicate that the program has a unique value in supporting young persons with acquired brain injury to create a meaningful everyday life through occupation, work ability, and social interaction.
La curiosité du consommateur : synthèse bibliométrique et bibliographique
Authors: BECK Marie 
Published: March 2024

Résumé La curiosité est un concept particulièrement étudié en psychologie. Elle est aujourd’hui utilisée en marketing pour soutenir une stratégie d’attraction, de motivation ou de captation de l’attention par les praticiens. Cet article propose une synthèse multidisciplinaire sur ce concept à travers une analyse bibliométrique et une analyse bibliographique. Un cadre conceptuel est proposé pour les chercheurs en marketing s’intéressant à la curiosité en proposant une nouvelle définition du concept, de ses antécédents et de ses effets. Un agenda de recherche priorisé par les praticiens peut servir de base à de futurs travaux.
Poly(lactic acid)/poly(ε-caprolactone) blends: Separate effects of nanocalcium carbonate and glycidyl methacrylate on interfacial characteristics
Authors: Negaresh Mohammadmahdi , Javadi Azizeh , Garmabi Hamid 
Published: March 2024

To expand the potential applications of polylactic acid (PLA), it is essential to incorporate a highly flexible polymer into the blend. Polycaprolactone (PCL) is an ideal choice due to its ductility and biodegradability. However, blending PLA with PCL resulted in weak mechanical properties. To address this issue, glycidyl methacrylate (GMA) and nano calcium carbonate (NCC) were introduced to enhance the adhesion at the interface between PLA and PCL. Scanning Electron Microscope (SEM) images provided clear visual evidence of the impact of GMA and NCC on the morphology of the blend. Both components were effective in reducing the size of the dispersed PCL phase, shrinking it to approximately half the size of the original blend. Spectroscopic analysis revealed that GMA caused a reaction between its epoxy group and the hydroxyl and carboxyl groups of PLA and PCL. This reaction led to the formation of strong peaks in the 6.5 to 7.5 range in 1H NMR, as well as peaks at 76 and 139 ppm in 13C NMR. These findings were further corroborated by FT-IR, which demonstrated that NCC, despite its surface coating, did not create any new bonds. Rheological studies further demonstrated the positive effects of GMA and NCC. Both the storage modulus (G′) and complex viscosity (η*) of the blends increased, showing improved post-processing performance. Investigation into the shear-thinning behavior of the uncompatibilized blends revealed that NCC caused a significant decrease in complex viscosity at higher frequencies, indicating the disruption of the nanoparticle network. The power-law slope was measured to be 0.62. In contrast, the blend containing the compatibilizer demonstrated a moderate decrease in viscosity, with a power-law slope of 0.36. To analyze the behavior of the PLA/PCL blends in the presence of compatibilizers and nanoparticles at intermediate frequencies, the Palirene model was utilized. The superior integrity of the compatibilized blend was effectively demonstrated by the model, which showed enhanced stress transfer and phase relaxation.
Expression of Calretinin in the Cecal Muscularis Interna: Observation and Hypothetical Relevance to Appendicitis
Authors: Kapur Raj P. 
Published: March 2024

Background: The unexpected observation of calretinin immunoreactivity in smooth muscle cells in the muscularis propria of the cecum led to a more detailed examination of calretinin expression and its possible relationship to propulsive contractile activity around the vermiform appendix. Methods: Immunohistochemistry and RNA in situ hybridization were performed to analyze calretinin expression in intestinal samples from 33 patients at ages ranging from mid-gestation fetuses to adults, as well as in some potentially relevant animal models. Dual immunolabeling was done to compare calretinin localization with markers of smooth muscle and interstitial cells of Cajal. Results: Calretinin expression was observed consistently in the innermost smooth muscle layers of the muscularis interna in the human cecum, appendiceal base, and proximal ascending colon, but not elsewhere in the intestinal tract. Calretinin-positive smooth muscle cells did not co-express markers located in adjacent interstitial cells of Cajal. Muscular calretinin immunoreactivity was not detected in the ceca of mice or macaques, species which lack appendices, nor in the rabbit cecum or appendix. Conclusions: Localized expression of calretinin in cecal smooth muscle cells may reduce the likelihood of retrograde, calcium-mediated propulsive contractions from the proximal colon and suppress pro-inflammatory fecal stasis in the appendix.
Prediction of disease activity and treatment failure in relapsing–remitting MS patients initiating daily oral DMTs
Authors: Pappolla Agustin , Auger Cristina , Sao-Aviles Augusto , Tur Carmen , Rodriguez-Barranco Marta , Cobo-Calvo Álvaro , Mongay-Ochoa Neus , Rodríguez-Acevedo Breogán , Zabalza Ana , Midaglia Luciana , Carbonell-Mirabent Pere , Carvajal Rene , Castilló-Justribó Joaquín , Braga Nathane , Bollo Luca , Vidal-Jordana Angela , Arrambide Georgina , Nos Carlos , Salerno Annalaura , Galán Ingrid , Comabella Manuel , Sastre-Garriga Jaume , Tintoré Mar , Rovira Alex , Montalban Xavier , Río Jordi 
Published: March 2024

Background: Limited data exist regarding treatment response prediction to oral disease-modifying therapies (DMTs) in multiple sclerosis (MS). Objectives: We assessed the capacity of available scoring systems to anticipate disease activity parameters in naïve relapsing–remitting MS (RRMS) patients initiating daily oral DMTs, hypothesizing that they exhibit different predictive potentials. Methods: We conducted a retrospective study and applied the Rio Score (RS), modified Rio Score (mRS), and MAGNIMS Score 12 months after DMT initiation. At 36 months, we examined their ability to predict evidence of disease activity (EDA) components and treatment failure by logistic regression analysis. Results: Notably, 218 patients (62.4% females) initiating dimethyl fumarate, teriflunomide, and fingolimod were included. At 36 months, the RS high-risk group predicted evidence of clinical activity (odds ratio (OR) 10 [2.7–36.9]) and treatment failure (OR 10.6 [3.4–32.5]) but did not predict radiological activity (OR 1.9 [0.7–5]). The mRS non-responders group did not predict EDA and treatment failure. RS, mRS, and MAGNIMS 0 categories showed significantly lower EDA and treatment failure than the remainder. Conclusion: Scoring systems present different predictive abilities for disease activity parameters at 36 months in MS patients initiating daily oral therapies, warranting further adjustments (i.e. introduction of fluid biomarkers) to depict disease activity status fully.
Family language policy in tension: Conflicting language ideologies and translanguaging practices in multilingual families
Authors: Reichmuth Heather L. 
Published: March 2024

Aims and objectives: This paper highlights the conflicting language ideologies and translanguaging practices of a transcultural (Korean/Canadian) Korean/English-speaking family residing in South Korea through the lens of family language policy. Methodology: This paper draws on qualitative case study methods. Data collected consisted of interview data, language portraits, audio and video recorded family discussion of the language portraits, familial meals, and board/card game playing, as well as participant journal entries. The data from this paper comes from a larger project. Data and analysis: Data were gathered from four members of a multilingual family residing in South Korea. Data were coded and analyzed iteratively using thematic analysis. Findings: Findings from this paper suggest that language ideologies among multilingual family members vary due to the influence of local language ideologies and individual language experiences; this can lead to a disconnect between language practices and language ideologies and a multilingual identity in children. Originality: To my knowledge, this paper is the first study to use a family language policy lens in a transcultural multilingual family in South Korea. In addition, the study utilized unique data collection activities such as the video-recorded discussion of family member language portraits. Significance: This paper argues for parents in multilingual families to take a translanguaging stance when considering their language policies in the home to support their children’s multilingual identities. This is the first paper to take this stance by involving all family members, and by using multiple sources of data, including language practices. Furthermore, this paper takes a critical approach to the lens of family language policy.
Interference effects on two rectangular tall buildings with coupling bridge in close proximity
Authors: Sadhukhan Souvick , Das Arghyadip , Bhattacharya Satadru , Dalui Sujit Kumar 
Published: March 2024

The study is on the variation of pressure in different faces of rectangular plan-shaped tall buildings with interference conditions due to the presence of another building with the same shape and dimension connected through a multipurpose bridge. The analysis is done on computational fluid dynamics (namely ANSYS CFX) for 0° to 90° wind incidence angle (WIA). The buildings are spaced 60 m from each other. Different cases have been taken and analyzed based on the different positions of the bridge (i.e., 0.33H, 0.5H, and 0.67H) and compared with the isolated case (i.e., buildings without the bridge). A comparison study has been done in the form of interference factor (IF), so we can clearly understand the effect of the bridge at different heights of the building and isolated conditions on rectangular plan-shaped buildings. The study shows that when the bridge is at 0.5H and 0.33H, the force coefficient along X and Y produces similar results to an isolated condition for WIA of 60° and 30°, respectively.
A Longitudinal Dose-Response Curve Between Leisure-Time Physical Activity and the Prevalence of Diabetes Based on the Different Levels of Cognitive Function Among Older Adults
Authors: Lee Jungjoo , Kim Junhyoung , Ju Hyo Jin , An Sang Joon , Woo Bomi 
Published: March 2024

This study investigated a dose-response relationship between Leisure-Time Physical Activity participation (LTPA) and the risk of diabetes and a comparison of the risk across different cognitive function groups among older adults. The Health and Retirement Study data were used from 2012 to 2020 (n = 18 746). This study conducted a Cox Proportional Hazard Regression to investigate the Dose-Response Curve between the prevalence of diabetes and the covariates following a level of LTPA participation. The result presented that the Odds Ratio continuously decreased as the level of LTPA participation increased. Among the three cognitive function groups, the high group (OR = .43, P < .05) and the mid group (OR = .71, P < .05) had a larger negative slope coefficient than the low group. This study found that LTPA participation reduces the risk of diabetes and gives evidence for the importance of cognitive function in reducing the prevalence of diabetes.