bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis of lead-free Cu/CuFeO2/CZTS thin film as a novel photocatalytic hydrogen generator from wastewater and solar cell applications
Authors: Ali Amira H. , Ahmed Ashour M. , Abdelhamied M. M. , Abdel-Khaliek Ahmed A. , Abd El Khalik S. , Abass Safaa M. , Shaban Mohamed , Hasan Fuead , Rabia Mohamed 
Published: April 2024

AbstractThe sewage water is tested as a source of hydrogen production with a high efficiency value of 25.44% using Cu/CuFeO2 (delafossite)/CZTS (Cu2ZnSnS4, kesterite) as an investigated photocatalyst. The X-ray diffraction (XRD) analysis of the investigated photocatalyst (Cu/CuFeO2/CZTS) revealed a compact crystalline material, as witnessed by the diffraction peaks with high intensities. From the optical characterization, the recorded band gap values of Cu/CuFeO2/CZTS, Cu/CuFeO2, and CZTS are 1.15, 1.97, and 1.43 eV, respectively, inferring an obvious enhancement in the optical properties of the investigated photocatalyst, Cu/CuFeO2/CZTS. The photoelectrochemical (PEC) performance of the investigated photocatalyst for hydrogen (H2) generation was examined in wastewater. The current–time characteristic and the PEC behavior of Cu/CuFeO2/CZTS in dark and under light illumination using various power densities, monochromatic wavelengths, and different temperatures were studied. The current densities (JPh) under light illumination and (Jo) in the dark were − 8.0 and − 0.7 mA cm−2, respectively. The H2 generation rate for the Cu/CuFeO2/CZTS electrode was 0.049 mA/h. The thermodynamic parameters, respectively, ΔS*, ΔE, and ΔH* were 28.76 kJ mol−1 K−1, 21.0, and 18.28 kJ mol−1 at 390 nm. The findings of the work hold great promise for addressing energy production and the hindrances of sewage treatment at the same time.
Hidden costs of entering self-employment: the spouse’s psychological well-being
Authors: Alshibani Safiya Mukhtar , Kristoffersen Ingebjørg , Volery Thierry 
Published: April 2024

Abstract
Spouses are known to play a critical supportive role for the self-employed, yet very little evidence is available concerning how entrepreneurial pursuits affect the spouse. The present analysis offers a contribution by evaluating short-term psychological well-being dynamics among spouses of individuals entering self-employment, using panel survey data from Australia. We construct matched control samples based on a range of relevant characteristics to mitigate selection bias and find that spouses of self-employed individuals report substantially higher levels of well-being before entry into self-employment and experience a modest but statistically significant decrease in well-being following entry. This is consistent with the hypothesis that self-employment demands substantial psychological capital from spouses. These patterns hold for both genders, with only moderate gender differences identified. In contrast, spouses of those entering self-employment from unemployment report improvements in well-being.
(Self-)Envy, Digital Technology, and Me
Authors: Osler Lucy 
Published: April 2024

AbstractUsing digital technology, in particular social media, is often associated with envy. Online, where there is a tendency for people to present themselves in their best light at their best moments, it can feel like we are unable to turn without being exposed to people living out their perfect lives, with their fancy achievements, their beautiful faces and families, their easy wit, and wide social circles. In this paper, I dive into the relationship between envy and digital technology. I offer an enriched account of envy that aims to establish both the situated nature of envy, as well as (more controversially) the possibility of self-envy. I explore how features of digital technology not only increase the frequency with which we might experience envy directed at others, but also envy directed at other versions of one’s self. For online, we not only encounter idealized versions of others but digitally idealized versions of our selves. Moreover, I argue that digital technology does not only increase the likelihood of experiencing self-envy but makes the experience less cognitively onerous. I conclude by considering how current digital technology shapes what we envy.
ENSO dataset & comparison of deep learning models for ENSO forecasting
Authors: Mir Shabana , Arbab Masood Ahmad , Rehman Sadaqat ur 
Published: April 2024

AbstractForecasting the El Nino-Southern Oscillation (ENSO) is a challenging task in climatology. It is one of the main factors responsible for the Earth’s interannual climatic fluctuation and can result in many climatic anomalies. The impacts include natural disasters (floods, droughts), low & high agriculture yields, price fluctuation, energy demand, availability of water resources, animal movement, and many more. This study presents a comprehensive ENSO dataset containing standard indicators and other relevant data to facilitate ENSO analysis and forecasting. To ensure the dataset's validity and reliability, we performed extensive data analysis and trained four basic deep models for time series forecasting (i.e. CNN, RNN, LSTM, and hybrids). The data analysis confirmed the accuracy and suitability of the dataset for ENSO forecasting. The LSTM model achieved the best fit to the data, leading to superior performance in forecasting ENSO events.
A phase 2, open-label study of ibrutinib plus rituximab in Japanese patients with Waldenstrom’s macroglobulinemia
Authors: Izutsu Koji , Kato Hisashi , Sekiguchi Naohiro , Fujisaki Tomoaki , Kawakita Toshiro , Obara Naoshi , Matsue Kosei , Nishimoto Mitsutaka , Hatayama Tomoyoshi , Inagaki Mitsuo , Fujikawa Ei 
Published: April 2024

AbstractIbrutinib is a first-in-class Bruton kinase inhibitor against B-cell neoplasms including Waldenström macroglobulinemia (WM). This study evaluated the efficacy and safety of ibrutinib-rituximab in Japanese patients with WM. Patients received ibrutinib 420 mg orally once daily plus weekly rituximab 375 mg/m2 IV (8 infusions total). The primary end point was major response rate (MRR; PR or better) by Independent Review Committee assessment. Secondary endpoints were progression-free survival (PFS), safety, pharmacokinetics, and biomarkers. Primary analysis was conducted in 16 patients [baseline, treatment naïve: 8 (50.0%); relapsed/refractory WM: 8 (50.0%)] who received ibrutinib-rituximab, after all patients completed Week 57 or end of treatment. At primary analysis, MRR was 87.5% [14/16 patients; 95% CI: 61.7, 98.4%; p < 0.0001 (null hypothesis: 32% response rate)]. At final analysis (median study intervention duration: 34.4 months, median follow-up: 35.0 months), MRR was unchanged at 87.5%, but VGPR [6/16 (37.5%)] and PR [8/16 (50.0%)] improved. Prior treatment status did not affect response. At final analysis, median PFS was not reached [36-month PFS rate: 86% (95% CI: 55, 96%)]. No critical safety signals were reported. This study demonstrated a positive benefit/risk profile of ibrutinib-rituximab in Japanese patients with WM, consistent with the iNNOVATE study.
Hypoxic microenvironment-induced exosomes confer temozolomide resistance in glioma through transfer of pyruvate kinase M2
Authors: Li Guofu , Xiong Ziyu , Li Ying , Yan Cong , Cheng Yingying , Wang Yuwen , Li Jingwei , Dai Zifeng , Zhang Dongdong , Du Wenzhong , Men Chunyang , Shi Changbin 
Published: April 2024

Abstract
Objective
Glioma, a malignant primary brain tumor, is notorious for its high incidence rate. However, the clinical application of temozolomide (TMZ) as a treatment option for glioma is often limited due to resistance, which has been linked to hypoxic glioma cell-released exosomes. In light of this, the present study aimed to investigate the role of exosomal pyruvate kinase M2 (PKM2) in glioma cells that exhibit resistance to TMZ.

Methods
Sensitive and TMZ-resistant glioma cells were subjected to either a normoxic or hypoxic environment, and the growth patterns and enzymatic activity of glycolysis enzymes were subsequently measured. From these cells, exosomal PKM2 was isolated and the subsequent effect on TMZ resistance was examined and characterized, with a particular focus on understanding the relevant mechanisms. Furthermore, the intercellular communication between hypoxic resistant cells and tumor-associated macrophages (TAMs) via exosomal PKM2 was also assessed.

Results
The adverse impact of hypoxic microenvironments on TMZ resistance in glioma cells was identified and characterized. Among the three glycolysis enzymes that were examined, PKM2 was found to be a critical mediator in hypoxia-triggered TMZ resistance. Upregulation of PKM2 was found to exacerbate the hypoxia-mediated TMZ resistance. Exosomal PKM2 were identified and isolated from hypoxic TMZ-resistant glioma cells, and were found to be responsible for transmitting TMZ resistance to sensitive glioma cells. The exosomal PKM2 also contributed towards mitigating TMZ-induced apoptosis in sensitive glioma cells, while also causing intracellular ROS accumulation. Additionally, hypoxic resistant cells also released exosomal PKM2, which facilitated TMZ resistance in tumor-associated macrophages.

Conclusion
In the hypoxic microenvironment, glioma cells become resistant to TMZ due to the delivery of PKM2 by exosomes. Targeted modulation of exosomal PKM2 may be a promising strategy for overcoming TMZ resistance in glioma.
A new approach to calculate CO2 displacement recovery considering near miscibility in tight oil reservoirs
Authors: Yang Song , Tian Xiaofeng 
Published: April 2024

AbstractNear miscibility widely exists in carbon dioxide (CO2) injection development projects. However, there is no existing approach to quantify the effect of near miscibility on oil recovery. In this paper, slim tube experiments were conducted to study near miscible region. The oil displacement efficiency curve is divided into immiscibility, near miscibility and miscibility. And three linear function is obtained, respectively. Then, the space between production well and CO2 injection well is discrete to characterize the effect of near miscibility on oil recovery. Then, a new approach is proposed to calculate oil recovery of CO2 displacement in tight oil reservoirs. This approach can calculate oil recovery considering near miscibility. It is found that minimum miscibility pressure (MMP) without considering near miscibility is 4 MPa lower than considering near miscibility. The near miscible pressure range is from 0.77 times to 1 time MMP considering near miscibility. Oil displacement efficiency difference reaches to be the maximum when the pressure is the minimum miscibility pressure without considering near miscibility. The maximum of the oil displacement efficiency difference is 3.4%. The optimal formation pressure considering near miscibility is 5 MPa larger than that without considering near miscibility. The oil recovery considering near miscibility is from 0.9 to 1.3% lower than that not considering near miscibility. It reaches to be the maximum when the pressure is the optimal formation pressure level without considering near miscibility. The maximum of the oil recovery difference is 1.3%.
Spanish GDP short-term point and density forecasting using a mixed-frequency dynamic factor model
Authors: Fresoli Diego 
Published: April 2024

AbstractWe have assessed the effect of data releases when constructing short-term point and density forecasts of the Spanish gross domestic product growth. For this purpose, we considered a real-forecasting exercise in which we defined several pseudo-data vintages that had a mixture of monthly and quarterly frequencies and were unbalanced towards the end of the sample. We implemented a mixed-frequency dynamic factor model to deal with data features and to produce gross domestic product forecasts. We evaluated the predictive content of data releases from point and density forecast perspectives, the latter aspect of the analysis being previously unexplored in the literature producing Spanish gross domestic product short-term forecasts. We observed significant improvements in point forecasts as information is released throughout the quarter, confirming existing results. Additionally, our findings indicated substantial enhancements in the accuracy of density forecasts as new data releases materialized.
‘I want to scream it from the rooftops now […] there are other pathways’: What young people learned from a co-designed post-secondary transition programme
Authors: Ryan Juliana , Luguetti Carla , Eckersley Bill , Howard Amy , Hansen Chloe , Ford Chloe , Craig Sarah , Brown Claire 
Published: April 2024

Abstract
This paper uses the framework of transition as becoming to explore what young people learned from participating in a post-secondary transition program that was co-designed by young people. The 9-week youth participatory action research (YPAR) involved six staff collaborators (SCs) and seven youth collaborators (YCs). Data comprised recordings of weekly group meetings, group interviews, reflections and artefacts such as planning documents, graphic organisers and writing. We discuss the findings using two themes that we identified together as a team of YCs and SCs. The first represents how YCs became aware of and vocalised understandings of life after secondary school as a diverse and fluid process. The second describes and interrogates how YCs became more confident and empowered, showing the importance of critical consciousness, reflection and action in seeking transformation. We conclude that conceptualising transition as becoming enables us to collectively make sense of the diverse ways we co-construct life experiences and directions.
Human Nasal Inferior Turbinate-Derived Neural Stem Cells Improve the Niche of Substantia Nigra Par Compacta in a Parkinson’s Disease Model by Modulating Hippo Signaling
Authors: Choi Junwon , Park Sun Wha , Lee Hyunji , Kim Do Hyun , Kim Sung Won 
Published: April 2024

Abstract
Background:
Parkinson’s disease (PD) is one of the most prevalent neurodegenerative diseases, following Alzheimer’s disease. The onset of PD is characterized by the loss of dopaminergic neurons in the substantia nigra. Stem cell therapy has great potential for the treatment of neurodegenerative diseases, and human nasal turbinate-derived stem cells (hNTSCs) have been found to share some characteristics with mesenchymal stem cells. Although the Hippo signaling pathway was originally thought to regulate cell size in organs, recent studies have shown that it can also control inflammation in neural cells.

Methods:
Dopaminergic neuron-like cells were differentiated from SH-SY5Y cells (DA-Like cells) and treated with 1-Methyl-4-phenylpyridinium iodide to stimulate Reactive oxidative species (ROS) production. A transwell assay was conducted to validate the effect of hNTSCs on the Hippo pathway. We generated an MPTP-induced PD mouse model and transplanted hNTSCs into the substantia nigra of PD mice via stereotaxic surgery. After five weeks of behavioral testing, the brain samples were validated by immunoblotting and immunostaining to confirm the niche control of hNTSCs.

Results:
In-vitro experiments showed that hNTSCs significantly increased cell survival and exerted anti-inflammatory effects by controlling ROS-mediated ER stress and hippocampal signaling pathway factors. Similarly, the in-vivo experiments demonstrated an increase in anti-inflammatory effects and cell survival rate. After transplantation of hNTSCs, the PD mouse model showed improved mobility and relief from PD symptoms.

Conclusion:
hNTSCs improved the survival rate of dopaminergic neurons by manipulating the hippocampal pathway through Yes-associated protein (YAP)/transcriptional coactivator with a PDZ-binding motif (TAZ) by reducing inflammatory cytokines. In this study, we found that controlling the niche of hNTSCs had a therapeutic effect on PD lesions.
Prospective evaluation of a novel device for ultrasound-guided percutaneous treatment of carpal tunnel and trigger finger disease. Efficacy and safety of sono-instruments®
Authors: Moungondo Fabian , Van Rompaey Hannah , Moussa Mohamad K. , Schuind Frédéric 
Published: April 2024

Abstract
Purpose
To evaluate the safety and effectiveness of percutaneous release procedures under sonography using Sono-Instruments® in the treatment of carpal tunnel syndrome (CTS) and trigger finger (TF).

Methods
Prospective study involving 30 patients, divided into two groups (15 CTS, and 15 TF). The primary outcomes were surgical performance-related outcomes (visibility, ease of use, satisfaction, duration) using Sono-Instruments® and patient-related outcomes (pain, activity limitations, time to return to work, functional scores). Secondary outcomes included complications. Patients were followed for two months post-operatively.

Results
In the CTS group, the average age of the patients was 58.7 years. The percutaneous release of the transverse carpal ligament was effectively completed in all cases, with excellent device performance and no adverse events. At one week, all patients could wash their hands, 80% could perform activities of daily living, and 80% of those working had returned to their activities. At two months, all patients had resumed all activities. Pillar pain was still present in 53.3%. In the TF group, the patients had an average age of 57.9 years. The percutaneous release of the A1 annular pulley was successful in all cases, with excellent device performance and no adverse events. At one week, all patients could wash their hands, 93.3% could do all activities of daily living, and 75% of those working were back to their professional activities. At two months, all patients were back to all activities of daily living and work. The DASH score was significantly improved at two months, compared to preoperative, for both groups (p < 0.001).

Conclusion
Percutaneous sono-guided release using Sono-Instruments® is safe and efficient, and associated with quick functional recovery.

Level of evidence
II.
Unpacking Neighborhood Socioeconomic Status in Children’s Health Research from an Environmental Justice Perspective: A Scoping Review
Authors: Bhaktaram Ananya , Kress Amii M. , Li Zone , Knapp Emily A. 
Published: April 2024

Abstract
Purpose of Review
Clearly defining and measuring neighborhood socioeconomic status (nSES) is a key first step in achieving environmental justice, as the disproportionate distribution of environmental hazards and access to resources is heavily influenced by socioeconomic factors. This scoping review explores the definition of neighborhoods, measurement of neighborhood socioeconomic status (nSES), and studies that evaluated the association between nSES and child health in accordance with PRISMA guidelines.

Recent Findings
We identified 4112 articles published on US pediatric populations between 2013 and 2022. We identified 170 distinct indicators across seven broad domains of nSES used to create 121 different measures of nSES across the 206 publications included in this review. While there is considerable interest in nSES and children’s health, there is also substantial variation in the measurement of neighborhood as a geographic unit and nSES as a construct.

Summary
We observed methodological challenges related to the identification of neighborhood boundaries, indicator selection, and nSES measure definition(s). We discuss common pitfalls in neighborhood research that can complicate identifying, targeting, and resolving environmental injustices. Lastly, we put forward a series of recommendations to reduce measurement error and improve inference, in addition to reporting recommendations for neighborhoods and health research that can aid in improving our understanding of pathways between neighborhood context and child health, inform policy development, and allocate resources to achieve environmental justice.
Die Diabetesinzidenz bei Kindern und Jugendlichen in Österreich steigt weiter!
Authors: Nagl Katrin 
Published: April 2024

ZusammenfassungSeit 1989 verfügt Österreich über ein Diabetes-Inzidenz-Register für Kinder unter 15 Jahren. Eine aktuelle Auswertung zeigte, dass die Inzidenz von Typ-1-Diabetes (T1D) wieder steigt und im Jahr 2021 einen Höchststand erreichte. Diese Zusammenfassung gibt einen Überblick über die Entwicklung von Diabetesinzidenzen bei Kindern in Österreich mit besonderem Fokus auf T1D und Typ-2-Diabetes (T2D) sowie deren potenziellen Zusammenhang mit der COVID-19-Pandemie und anderen Einflussfaktoren. Da in den letzten Jahren ein eklatanter Anstieg an diabetischer Ketoazidose bei Diagnosestellung zu verzeichnen war, wird die Bedeutung von Screening, Prävention und Früherkennung im Zusammenhang mit T1D bei Kindern betont.
Wie man jemanden „bloß als Mittel“ gebraucht
Authors: Kleingeld Pauline 
Published: April 2024

ZusammenfassungDas Verbot, andere „bloß als Mittel“ zu gebrauchen, ist eines der bekanntesten und einflussreichsten Elemente der Moralphilosophie von Immanuel Kant. Es wird jedoch weithin als unmöglich angesehen, die Bedingungen, unter denen dieses Verbot verletzt wird, genau zu bestimmen. Auf der Grundlage einer erneuten Prüfung der kantischen Texte entwickelt dieser Aufsatz eine neue Interpretation der Bedingungen, unter denen jemand „bloß als Mittel“ gebraucht wird. Es wird argumentiert, dass diese Interpretation nicht nur durch die Texte verlässlich gestützt wird, sondern auch erhebliche philosophische Vorteile gegenüber alternativen Lesarten aufweist.
Multi-Trait Body Shape Phenotypes and Breast Cancer Risk in Postmenopausal Women: A Causal Mediation Analysis in the UK Biobank Cohort
Authors: Amadou Amina , Freisling Heinz , Sedlmeier Anja M. , Bohmann Patricia , Fontvieille Emma , Weber Andrea , Konzok Julian , Stein Michael J. , Peruchet-Noray Laia , Jansana Anna , Noh Hwayoung , His Mathilde , Gan Quan , Baurecht Hansjörg , Fervers Béatrice 
Published: April 2024

AbstractBody shape phenotypes combining multiple anthropometric traits have been linked to postmenopausal breast cancer (BC). However, underlying biological pathways remain poorly understood. This study investigated to what extent the associations of body shapes with postmenopausal BC risk is mediated by biochemical markers. The study included 176,686 postmenopausal women from UK Biobank. Four body shape phenotypes were derived from principal component (PC) analysis of height, weight, body mass index, waist and hip circumferences, and waist-to-hip ratio (WHR). The four-way decomposition of the total effect was used to estimate mediation and interaction effects simultaneously as well as the mediated proportions. After 10.9 years median follow-up, 6,396 incident postmenopausal BC were diagnosed. There was strong evidence of positive associations between PC1 (general obesity) and PC2 (tall, low WHR), and BC risk. The association of PC1 with BC risk was positively mediated by testosterone and negatively by insulin-like growth factor-1 (IGF-1), with the overall proportion mediated (sum of the mediated interaction and pure indirect effect (PIE)) accounting for 11.4% (95% confidence intervals: 5.1 to 17.8%) and -12.2% (-20.5% to -4.0%) of the total effect, respectively. Small proportions of the association between PC2 and BC were mediated by IGF-1 (PIE: 2.8% (0.6 to 4.9%)), and sex hormone-binding globulin (SHBG) (PIE: -6.1% (-10.9% to -1.3%)). Our findings are consistent with differential pathways linking different body shapes with BC risk, with a suggestive mediation through testosterone and IGF-1 in the relationship of a generally obese body shape and BC risk, while IGF-1 and SHBG may mediate a tall/lean body shape-BC risk association.