bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metabolism of androsta‐1,4,6‐triene‐3,17‐dione and detection by gas chromatography/mass spectrometry in doping control
Authors: Parr Maria K. , Fußhöller Gregor , Schlörer Nils , Opfermann Georg , Piper Thomas , Rodchenkov Grigory , Schänzer Wilhelm 
Published: December 2008

AbstractThe urinary metabolism of the irreversible aromatase inhibitor androsta‐1,4,6‐triene‐3,17‐dione was investigated. It is mainly excreted unchanged and as its 17β‐hydroxy analogue. For confirmation, 17β‐hydroxyandrosta‐1,4,6‐trien‐3‐one was synthesized and characterized by nuclear magnetic resonance (NMR) in addition to the parent compound. In addition, several reduced metabolites were detected in the post‐administration urines, namely 17β‐hydroxyandrosta‐1,4‐dien‐3‐one (boldenone), 17β‐hydroxy‐5β‐androst‐1‐en‐3‐one (boldenone metabolite), 17β‐hydroxyandrosta‐4,6‐dien‐3‐one, and androsta‐4,6‐diene‐3,17‐dione. The identification was performed by comparison of the metabolites with reference material utilizing gas chromatography/mass spectrometry (GC/MS) of the underivatized compounds and GC/MS and GC/tandem mass spectrometry (MS/MS) of their trimethylsilyl (TMS) derivatives. Alterations in the steroid profile were also observed, most obviously in the androsterone/testosterone ratio. Even if not explicitly listed, androsta‐1,4,6‐triene‐3,17‐dione is classified as a prohibited substance in sports by the World Anti‐Doping Agency (WADA) due to its aromatase‐inhibiting properties. In 2006 three samples from human routine sports doping control tested positive for metabolites of androsta‐1,4,6‐triene‐3,17‐dione. The samples were initially found suspicious for the boldenone metabolite 17β‐hydroxy‐5β‐androst‐1‐en‐3‐one. Since metabolites of androst‐4‐ene‐3,6,17‐trione were also present in the urine samples, it is presumed that these findings were due to the administration of a product like ‘Novedex Xtreme’, which could be easily obtained from the sport supplement market. Copyright © 2008 John Wiley & Sons, Ltd.
Determination of δ18O in soils: measuring conditions and a potential application
Authors: Schaub Monika , Seth Barbara , Alewell Christine 
Published: December 2008

AbstractThe stable oxygen isotope signature (δ18O) of soil is expected to be the result of a mixture of components within the soil with varying δ18O signatures. Thus, the δ18O of soils should provide information about the soil's substrate, especially about the relative contribution of organic matter versus minerals. As there is no standard method available for measuring soil δ18O, the method for the measurement of single components using a high‐temperature conversion elemental analyser (TC/EA) was adapted. We measured δ18O in standard materials (IAEA 601, IAEA 602, Merck cellulose) and soils (organic and mineral soils) in order to determine a suitable pyrolysis temperature for soil analysis. We consider a pyrolysis temperature suitable when the yield of signal intensity (intensity of mass 28 per 100 µg) is at a maximum and the acquired raw δ18O signature is constant for the standard materials used and when the quartz signal from the soil is still negligible. After testing several substances within the temperature range of 1075 to 1375°C we decided to use a pyrolysis temperature of 1325°C for further measurements. For the Urseren Valley we have found a sequence of increasing δ18O signatures from phyllosilicates to upland soils, wetland soils and vegetation. Our measurements show that the δ18O values of upland soil samples differ significantly from wetland soil samples. The latter can be related to the changing mixing ratio of the mineral and organic constituents of the soil. For wetlands affected by soil erosion, we have found intermediate δ18O signatures which lie between typical signatures for upland and wetland sites and give evidence for the input of upland soil material through erosion. Copyright © 2008 John Wiley & Sons, Ltd.
Retracted: Genetic diversity in hepatitis C virus (HCV): A brief review
Authors: Irshad Mohammad 
Published: December 2008

Abstract The following article from Reviews in Medical Virology, Genetic diversity in hepatitis C virus (HCV) a brief review, by M Irshad, published online on December 16 2008 in Wiley InterScience (www.interscience.wiley.com) has been retracted by agreement between the author, the journal Editor in Chief, P.D. Griffiths, and the publisher Wiley Blackwell. The retraction has been agreed due to overlap with the following article by P Simmonds, Genetic diversity and evolution of hepatitis C virus fifteen years on, published in Journal of General Virology, 2004, 85, 3173–3178.
Proof of the local REM conjecture for number partitioning. I: Constant energy scales
Authors: Borgs Christian , Chayes Jennifer , Mertens Stephan , Nair Chandra 
Published: December 2008

AbstractIn this article we consider the number partitioning problem (NPP) in the following probabilistic version: Given n numbers X1,…,Xn drawn i.i.d. from some distribution, one is asked to find the partition into two subsets such that the sum of the numbers in one subset is as close as possible to the sum of the numbers in the other set. In this probabilistic version, the NPP is equivalent to a mean‐field antiferromagnetic Ising spin glass, with spin configurations corresponding to partitions, and the energy of a spin configuration corresponding to the weight difference. Although the energy levels of this model are a priori highly correlated, a surprising recent conjecture of Bauke, Franz, and Mertens asserts that the energy spectrum of number partitioning is locally that of a random energy model (REM): the spacings between nearby energy levels are uncorrelated. More precisely, it was conjectured that the properly scaled energies converge to a Poisson process, and that the spin configurations corresponding to nearby energies are asymptotically uncorrelated. In this article, we prove these two claims, collectively known as the local REM conjecture. © 2008 Wiley Periodicals, Inc. Random Struct. Alg., 2009
An efficient scheme for removing compromised sensor nodes from wireless sensor networks
Authors: Wang Yong , Ramamurthy Byrav , Zou Xukai , Xue Yuyan 
Published: December 2008

AbstractThe goal of key management is to establish the required keys between sensor nodes which exchange data. A key management protocol includes two aspects: key distribution and key revocation. Key distribution has been extensively studied in the context of sensor networks. However, key revocation has received relatively little attention. In this paper, we first review and summarize the current key revocation schemes for sensor networks. Then, we present an efficient scheme, KeyRev, for removing compromised sensor nodes from a wireless sensor network (WSN). Unlike most proposed key revocation schemes focusing on removing the compromised keys on the sensor nodes, the KeyRev scheme uses key update techniques to obsolesce the keys owned by the compromised sensor nodes and thus remove the nodes from the network. We analyze the security of the KeyRev scheme and compare its performance against another centralized key revocation scheme and a distributed key revocation scheme. Our analyses show that the KeyRev scheme is secure in spite of not removing the pre‐distributed key materials at compromised sensor nodes. Simulation results also indicate that the KeyRev scheme is scalable and performs very well compared with other key revocation schemes in WSNs. Copyright © 2008 John Wiley & Sons, Ltd.
Normative barriers to imitation: social complexity of core competences in a mutual fund industry
Authors: Jonsson Stefan , Regnér Patrick 
Published: December 2008

AbstractImperfectly imitable resources are central in contemporary analysis of sustainable competitive advantage. While prior work has focused on limitations on the ability to imitate, we argue that it is only a third step in an imitation procedure that also involves the identification of what to imitate and the willingness to imitate. In this study we focus on this last step of unwillingness to imitate due to institutionalized professional norms on product appropriateness. Drawing on institutional theory, we test hypotheses and discuss the complex relationship between institutionalized norms, core competences, and systematic differences in the willingness to imitate. Copyright © 2008 John Wiley & Sons, Ltd.
Nicotine and Δ9‐tetrahydrocannabinol withdrawal induce Narp in the central nucleus of the amygdala
Authors: Reti Irving M. , Han Sungho , Miskimon Matthew , Rosen Jeffrey B. , Baraban Jay M. 
Published: December 2008

AbstractThe central nucleus of the amygdala plays a key role in mediating aversive responses to drug withdrawal, effects thought to contribute to continued drug use. In previous studies, we found that the immediate early gene Narp, which encodes a secreted protein that binds to AMPA receptors, is induced in this nucleus following opiate withdrawal. Furthermore, Narp deletion alters the acquisition and extinction of aversive conditioning induced by opiate withdrawal. We now report that Narp is also induced in the central nucleus following withdrawal from other drugs of abuse, nicotine and Δ9‐tetrahydrocannabinol, indicating that Narp is a common component of the transcriptional response triggered by drug withdrawal. Synapse 62:252–255, 2009. © 2008 Wiley‐Liss, Inc.
Chlamydia pneumoniae induces macrophage‐derived foam cell formation via PPAR α and PPAR γ‐dependent pathways
Authors: Mei Chun‐li , He Ping , Cheng Bei , Liu Wei , Wang Yan‐fu , Wan Jing‐jing 
Published: December 2008

AbstractIn the presence of low density lipoprotein (LDL), Chlamydia pneumoniae induces macrophage‐derived foam cell formation, a typical pathological feature of early atherosclerosis. However, its mechanism has not been fully understood. Peroxisome proliferator‐activated receptors (PPARs) are key regulators of macrophage lipid metabolism. This study therefore investigated the role that PPAR α and PPAR γ may play a role in C. pneumoniae‐induced foam cell formation. Oil Red O staining and Lipid mass quantification showed that LDL‐treated THP‐1 macrophages infected with high doses of C. pneumoniae (5 × 105 and 1 × 106 IFU) resulted in the large accumulation of lipid droplets and markedly increased the ratio of intracellular cholesteryl ester (CE) to total cholesterol (TC) (>50%). The results of RT‐PCR and Western blot indicated that C. pneumoniae infection dose‐dependently suppressed the expression of PPAR α and PPAR γ at mRNA and protein levels in LDL‐treated THP‐1 macrophages. PPAR α (fenofibrate) and PPAR γ (rosiglitazone) agonists, inhibited the accumulation of intracellular CE by C. pneumoniae in a dose‐dependent manner. Furthermore, C. pneumoniae‐induced foam cell formation was significantly suppressed by higher doses of fenofibrate (20 and 50 μM) and rosiglitazone (10 and 20 μM). These results first reveal that C. pneumoniae induces foam cell formation via PPAR α and PPAR γ‐dependent pathway, which may contribute to its pro‐atherogenic properties.
The BDI-II factor structure in pregnancy and postpartum: Two or three factors?
Authors: Carvalho Bos Sandra , Pereira Ana Telma , Marques Mariana , Maia Berta , Soares Maria João , Valente José , Gomes Ana , Macedo António , Azevedo Maria Helena 
Published: December 2008

AbstractThe purpose of the present study was to investigate the factor structure of the Beck Depression Inventory-II (BDI-II) in pregnancy and postpartum. Women were asked to fill in the BDI-II in their last trimester of pregnancy and at 3 months after delivery. A total of 331 pregnant women, with a mean age of 29.7 years (SD = 4.6), and 354 mothers, aged 30.6 years (SD = 4.6 years), answered the BDI-II. The first group was mainly nulliparas (65.6%) and the second group was mostly primiparas (57.4%). Factor analyses with principal components solution and varimax rotation were performed. Based on the scree test of Cattell a 2-factor solution and a 3-factor solution were explored. The 2-factor solution was identical in pregnancy and postpartum. Items loading in the Cognitive–Affective factor and in the Somatic–Anxiety factor were almost the same, though the Cognitive–Affective factor explained more of the BDI-II total variance in pregnancy, whereas in postpartum both factors explained similar total variances. The 3-factor solution of the BDI-II in pregnancy and postpartum slightly diverged. Besides the Cognitive–Affective and the Somatic–Anxiety factors, a third factor, Fatigue, was obtained in pregnancy while Guilt was the third factor identified in postpartum. This study reveals that the BDI-II 3-factor solution might be more appropriate to assess depressive symptoms in pregnancy and postpartum.
The Political “Nature” of Pregnancy and Childbirth
Authors: Johnson Candace 
Published: December 2008

Abstract.In this paper, I examine the theoretical debates concerning “medicalization” in relation to the empirical trend toward increased demand for “natural” options for childbirth. Many feminist theorists have argued that medical intervention in pregnancy and childbirth is both unwarranted and disempowering and devalues women's own abilities and experiences. Further, it is argued that medicalization (of seemingly natural events) is particularly damaging for women and other marginalized people. In this paper, I explore the claims (of both providers and consumers) concerning medical care for pregnancy and childbirth among privileged populations and ask why rejection of medical care for pregnancy and childbirth is not proportional to disadvantage. It appears to be the case that criticism of medical intervention in pregnancy and childbirth is strongest among privileged women and is expressed consistently as preference for “natural,” “traditional” or “normal” approaches and practices. Reverence for the natural, I argue, is a political claim that asserts social position, identity, and resistance. I consider this political claim to be embodied and demonstrated in the occurrence of a physical and psychic duality, a “split subjectivity,” that is exacerbated by the sharpness of the public-private divide in women's lives.Résumé.Dans cet article, j'examine le débat théorique sur la médicalisation à la lumière de la vogue actuelle croissante des options plus naturelles pour l'accouchement. De nombreux auteurs féministes ont soutenu que les interventions médicales durant la grossesse et l'accouchement étaient injustifiées et qu'elles privaient les femmes de leur autonomie, tout en dévaluant leur expérience et leurs aptitudes naturelles. De même, la médicalisation (de phénomènes apparemment naturels) est, selon certains, particulièrement néfaste pour les femmes et les groupes marginalisés. Dans cet article, j'explore les affirmations (à la fois des prestataires et des bénéficiaires) concernant l'assistance médicale durant la grossesse et l'accouchement parmi les populations favorisées et je soulève la question de savoir pourquoi le rejet de l'assistance médicale durant la grossesse et l'accouchement n'est pas surtout le fait des milieux défavorisés. Il semble, en effet, que les critiques envers les interventions médicales durant la grossesse et l'accouchement proviennent surtout des femmes de milieux favoriséset que ces dernières manifestent de manière constante une préférence pour les approches et les pratiques «naturelles», «traditionnelles» ou «normales». La révérence envers le naturel est, selon moi, une revendication politique afin d'affirmer sa position sociale, son identité et sa résistance. Je considère que cette revendication politique est incarnée et démontrée par l'existence d'une dualité physique et psychique, une «subjectivité divisée» qui est exacerbée par l'acuité de la division entre le monde public et le monde privé dans la vie des femmes.
La vice-présidence américaine contemporaine : une école pour la présidence?
Authors: Prémont Karine 
Published: December 2008

Résumé.La vice-présidence est probablement l'institution la plus sous-estimée de la démocratie américaine. Souvent la cible de quolibets, elle a cependant réussi à se transformer et à se définir au fil des années. Aujourd'hui, les vice-présidents sont presque automatiquement pressentis à la présidence et d'ailleurs, la majorité d'entre eux ont cette ambition. Que s'est-il donc passé pour que la vice-présidence devienne une institution d'où peut émaner un éventuel président? Pour répondre à cette question, nous examinons, dans un premier temps, les changements externes qui ont contribué à modifier les fonctions vice-présidentielles. Dans un deuxième temps, nous comparons quatre vice-présidents contemporains (Nixon, Ford, Mondale et Bush) pour tenter de voir s'il existe une corrélation entre le mode de gestion qu'ils ont adopté et leur succès ou leur échec durant leur campagne présidentielle. Finalement, nous abordons d'autres pistes de réflexion afin de cerner les éléments qui permettraient d'expliquer en quoi la vice-présidence est un atout pour d'éventuels candidats à la présidence.Abstract.The vice-presidency is probably the most unappreciated and the most underestimated institution of the American democracy. Often the target of gibes, it nevertheless achieved a radical transformation years after years. Now, vice-presidents are almost always considered for the presidency and moreover, the majority of them have the ambition to be president someday since World War II. What can explain that the vice-presidency, not ridiculed anymore, is now an institution where one can find the next president of the United States? To answer this question, we initially examine the external changes that affected the vice-presidential functions. Secondly, we compare four contemporary vice-presidents (Nixon, Ford, Mondale and Bush) in order to see if their management style is linked to their chances to be president. Finally, we talk about other considerations that could explain why the vice-presidency is a significant asset for those who want to be president.
Needs, Rights and “One Law for All”: Contemporary Debates in New Zealand Maori Politics
Authors: O'Sullivan Dominic 
Published: December 2008

Abstract. This paper examines contemporary debates in Maori politics by responding to the argument of the former leader of the opposition National party, Don Brash, that Maori public policy is most properly based on “need” alone because indigenous status offers no “rights” beyond those of common national citizenship. The paper's alternative argument is that the politics of indigeneity and associated theories of self-determination provide a way of avoiding a general belief that addressing need is all that is required to include Maori fairly in the national polity. It is argued that Maori ought to enjoy rights of indigeneity as the basis of an inclusive, cohesive and fair society.Résumé. Cette étude examine certains débats dans le domaine de la politique maorie en répondant aux propos de l'ancien chef du parti National, Don Brash, selon qui la politique publique maorie se baserait le plus aptement sur la notion du seul ‘besoin’, le statut de peuple indigène ne conférant aucun ‘droit’ au-delà de ceux qu'accorde la citoyennenté nationale régulière. Nous proposons par contre que la politique de l'indigénéité et les théories de l'auto-détermination qui y sont associées constituent un moyen de parer à une croyance généralisée qu'il suffirait de suppléer au besoin pour inclure avec justice les Maoris dans la politique nationale. Nous démontrerons que dans une société inclusive, cohésive et juste, les Maoris devraient jouir des droits accordés par l'indigénéité.
Ceylon's Kristallnacht: A Reassessment of the Pogrom of 1915
Authors: ROWELL GEORGE 
Published: December 2008

AbstractIn 1915 the south-western quadrant of Ceylon was convulsed by a week of rioting in which the Buddhist Sinhalese majority attacked a Muslim minority known as the Moors. The consensus amongst historians has long been that the pogrom (as it is best described) was the spontaneous result of religious tension and/or economic grievances at the popular level, with no leadership beyond the uncoordinated activities of local agitators. The consensus ignores significant evidence of wider orchestration, including the activities of itinerant gangs and other mobile agitators, the deliberate propagation of identical false rumours throughout the affected area, and the activities of individuals and societies associated with the Sinhala-Buddhist nationalist movement. Although the picture is far from complete, the best interpretation of the evidence is that this movement orchestrated the pogrom, albeit with varying degrees of success in each locality. That it was able to do so shows that Sinhala-Buddhist nationalism (as opposed to non-communalist, Ceylon-wide nationalism) was more deeply entrenched than is usually thought, which helps to explain Sri Lanka's political direction later in the century.
FROBENIUS CIRCULANT GRAPHS OF VALENCY FOUR
Authors: THOMSON ALISON , ZHOU SANMING 
Published: December 2008

AbstractA first kind Frobenius graph is a Cayley graph Cay(K,S) on the Frobenius kernel of a Frobenius group $K \rtimes H$ such that S=aH for some a∈K with 〈aH〉=K, where H is of even order or a is an involution. It is known that such graphs admit ‘perfect’ routing and gossiping schemes. A circulant graph is a Cayley graph on a cyclic group of order at least three. Since circulant graphs are widely used as models for interconnection networks, it is thus highly desirable to characterize those which are Frobenius of the first kind. In this paper we first give such a characterization for connected 4-valent circulant graphs, and then describe optimal routing and gossiping schemes for those which are first kind Frobenius graphs. Examples of such graphs include the 4-valent circulant graph with a given diameter and maximum possible order.
Pregnancy outcome after ovulation induction with aromatase inhibitors or clomiphene citrate in unexplained infertility
Authors: BADAWY AHMED , SHOKEIR TAREK , ALLAM ABDEL FATTAH , ABDELHADY HESHAM 
Published: December 2008

AbstractObjective. To evaluate the pregnancy outcome after ovulation induction with aromatase inhibitors or clomiphene citrate (CC). Design. A prospective, randomized, controlled trial. Setting. A university hospital center and a private practice setting. Population. The study comprised a total of 796 infertile women (1,100 cycles) and 200 spontaneously pregnant women (298 cycles) as a control group. Methods. Patients were allocated treatment either with 100 mg of CC daily (420 patients, 634 cycles), 5 mg of letrozole daily (269 patients, 323 cycles) or 1 mg of anastrozole daily (107 patients, 143 cycles) for 5 days starting on day 3 of menses. Main outcome measures. The occurrence of pregnancy, miscarriage and neonatal condition. Results. Pregnancy occurred in 167/1,398 cycles (11.9%) in total without significant differences between groups. The total miscarriage rate was 16.1% (varied between 14.2% in CC group and 19.9% in anastrozole group) without difference between spontaneous and stimulated pregnancies. There were 129 deliveries in all groups. There were no significant differences between the stimulated and spontaneous pregnancies as regards mean gestational age, premature deliveries, birth weight, SGA<10th percentile or five minutes Apgar score. There was one case of complete cleft palate and one case of major congenital heart problem in the letrozole group. There were two cases of talipus equinovarus in the CC and spontaneous pregnancy group. Conclusion. Aromatase inhibitors and CC resulted in favorable pregnancy outcomes and average miscarriage rates. Safety of the drugs for both the mother and fetuses was documented.