bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Graphical Approach to Visualize and Interpret Biochemically Coupled Biomechanical Models
Authors: Flanary Shannon M. , Peak Kara E. , Barocas Victor H. 
Published: February 2024

Abstract
The last decade has seen the emergence of progressively more complex mechanobiological models, often coupling biochemical and biomechanical components. The complexity of these models makes interpretation difficult, and although computational tools can solve model equations, there is considerable potential value in a simple method to explore the interplay between different model components. Pump and system performance curves, long utilized in centrifugal pump selection and design, inspire the development of a graphical technique to depict visually the performance of biochemically-coupled mechanical models. Our approach is based on a biochemical performance curve (analogous to the classical pump curve) and a biomechanical performance curve (analogous to the system curve). Upon construction of the two curves, their intersection, or lack thereof, describes the coupled model's equilibrium state(s). One can also observe graphically how an applied perturbation shifts one or both curves, and thus how the other component will respond, without rerunning the full model. While the upfront cost of generating the performance curve graphic varies with the efficiency of the model components, the easily interpretable visual depiction of what would otherwise be nonintuitive model behavior is valuable. Herein, we outline how performance curves can be constructed and interpreted for biochemically-coupled biomechanical models and apply the technique to two independent models in the cardiovascular space. The performance curve approach can illustrate and help identify weaknesses in model construction, inform user-applied perturbations and fitting procedures to generate intended behaviors, and improve the efficiency of the model generation and application process.
Kidney Function Trajectories and Right Heart Failure Following LVAD Implantation
Authors: Walther Carl P. , Civitello Andrew B. , Lamba Harveen K. , Mondal Nandan K. , Navaneethan Sankar D. 
Published: February 2024

Background
Preoperative kidney dysfunction is a risk factor for right heart failure (RHF) after implantation of a left ventricular assist device (LVAD). However, characteristic kidney function trajectories before and after post‐LVAD RHF are uncertain, so we investigated this.

Methods and Results
We identified individuals who received primary continuous‐flow LVAD implantation from July 1, 2014 to December 31, 2017 in the Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) data set. Incident RHF was ascertained using the INTERMACS definition at 1 and 3 months and classified as transient or persistent. Kidney function trajectories before and after RHF onset, and relationships of baseline kidney function with RHF risk at the different time points, were assessed. We identified 8076 LVAD recipients who met inclusion criteria. Incident RHF was present at 1 month in 26.4%. There were 4850 individuals with follow‐up at 3 months, with incident RHF in 4.2%. Kidney function trajectories differed from pre‐LVAD implantation to 1‐month follow‐up by RHF category, with those developing persistent RHF having no improvement in baseline kidney function. For trajectories before the 3‐month RHF ascertainment time, the shape was similar for those with and without RHF, with lower estimated glomerular filtration rate levels among those who developed RHF. Baseline estimated glomerular filtration rate levels below the normal range were associated with higher risk of RHF at 1 and 3 months.

Conclusions
In LVAD recipients, preimplantation kidney function and subsequent kidney function trajectories differed substantially by RHF at 1 and 3 months postimplantation, even after adjustment for several confounders. This may demonstrate bidirectional associations between kidney function and right ventricular function in LVAD recipients.
Schizophrenia and Types of Stroke: A Mendelian Randomization Study
Authors: Nakada Shinya , Ho Frederick K. , Celis‐Morales Carlos , Pell Jill P. 
Published: February 2024

Background
Previous studies suggest an association between schizophrenia and stroke, but no studies have investigated stroke subtypes. We examined potential causal associations between schizophrenia and a range of atherosclerotic, embolic, and hemorrhagic stroke outcomes.

Methods and Results

Two‐sample Mendelian randomization analyses were conducted. The summary‐level data (restricted to European ancestry) were obtained for schizophrenia and stroke: ischemic stroke, large‐artery stroke, small‐vessel stroke, cardioembolic stroke, and intracerebral hemorrhage. The associations between schizophrenia and each outcome were analyzed by an inverse variance weighting method primarily and Mendelian randomization Egger, weighted median, and weighted mode subsequently. The presence of pleiotropy was also tested by Cochran
Q
statistic,
I
2
index, and Mendelian randomization Egger intercept with scatter and funnel plots. We found associations between schizophrenia and cardioembolic stroke (odds ratio [OR], 1.070 [95% CI, 1.023–1.119]) and intracerebral hemorrhage (OR, 1.089 [95% CI, 1.005–1.180]) using inverse variance weighting. Little evidence of associations with the other stroke subtypes was found. Different Mendelian randomization methods corroborated the association with cardioembolic stroke but not intracerebral hemorrhage.

Conclusions
We have provided evidence of a potentially causal association between schizophrenia and cardioembolic stroke. Our findings suggest that cardiac evaluation should be considered for those with schizophrenia.
Growth and reproduction of the shrimp population in a lagoon system in southern Benin (West Africa)
Authors: Sintondji S. Wilfried , Sohou Zacharie , Baetens Katrijn , Lacroix Geneviève , Fiogbé Emile D. 
Published: February 2024

Abstract
The aim of this work was to characterize the growth and reproduction dynamics of shrimp in the Lac Nokoué-Chenal de Cotonou complex. The results of one year’s sampling from five stations (North, South, East, Central and West) of the lagoon complex revealed that linear growth in size in Lake Nokoué is decreasing over time in Macrobrachium macrobrachion (the most representative species of the genus Macrobrachium), but positive in Penaeus notialis (the most representative species of the genus Penaeus). Size-weight relationships indicate that the lowest growth coefficient () is obtained in immature males of Macrobrachium felicinum, while the highest growth coefficient () is obtained in mature females of Macrobrachium vollenhovenii, with an average of 2.84 for all shrimp species over both sexes considered. The test indicated that only the species Macrobrachium vollenhovenii has a significant sexual imbalance in favour of females in Lake Nokoué. Fisher’s Least Significant Difference test indicated that the estimated first sexual maturity sizes in Macrobrachium vollenhovenii and M. macrobrachion are significantly different from those estimated in M. felicinum at the threshold. However, the same test indicates that there is not enough evidence to differentiate the sizes of first sexual maturation in M. vollenhovenii and M. macrobrachion. This work revealed that Penaeus monodon was the only species to show better positive growth within all its groups in Lake Nokoué while exposed to anthropogenic effects. A gradual average increase in the size of Penaeus notialis in Lake Nokoué is found between the beginning and end of the saline intrusion (which confirms the life cycle of the species presented). Species of the genus Macrobrachium showed good reproductive capacity, with the absence of sexually mature Penaeus in this lagoon.
The impact of an abiotic variable, temperature, on larvae of the blue crab, Callinectes sapidus Rathbun, 1896 (Brachyura, Portunidae)
Authors: Gencer Övgü 
Published: February 2024

Abstract
Reductions in the size of mature blue crabs, Callinectes sapidus, which are commercially harvested, are of concern to the aquaculture industry. Through their role in the production of viable offspring, aquaculturists focus their attention in particular on female crabs, although the phenomenon will, of course, also affect the males. Meanwhile, decreases in size at maturity throughout the crab population may be the result of temperature alterations, at present also due to global climate change. Temperature-based shifts in growth can lead to changes in reproductive efficiency, as well as in size and age at maturity. In this study, the effects of temperature on the moulting frequency of blue crabs were investigated and survival rates have been calculated. The purpose of this study was to investigate the temperature dependence of survival and of the moulting processes for blue crab larvae, and to determine the effect of increasing temperature on moulting. The stages from zoea-1 to zoea-5 were examined at 16, 22, 26 and 30°C. The results show that there is a significant difference in growth and moulting, depending on the rearing temperature. As the temperature increases, the interval between moulting days can be seen to be shortened, and increasingly so with the progress in the growth of the crabs. Moulting-interval days became less with the growth of the crabs. The effect of a rise in temperature on growth per moult is also significant, and along the temperature range tested the optimum temperature was found to be 26°C. A reduction in the length of the intermoult period was observed from the lowest to the optimum temperature, while a sudden, sharp increase in the intermoult period above 26°C was observed as well.
High intensity interval exercise maintains irisin level and reduces body fat in overweight women
Authors: Karimullah A. , Fahma Wibowo N. , Indra Devi A. , Zahrotul Ilmi S. , Yosnengsih  , Azmy U. , Irwadi I. , Nahar Azmi Mohamed M. , Widyah Kusnanik N. , Purwanto B. , Herawati L. 
Published: February 2024

Abstract
A body mass index of more than 23 kg/m2 refers to being overweight. When overweight is not treated well, it can lead to obesity which is the condition of accumulation of excess adipose tissue. Obesity increases the risk of metabolic disease and physical activity has been known to prevent it. Irisin has been established to have a positive correlation with body fat burning. The purpose of this study is to analyse the acute effect of high intensity interval exercise on irisin level and body fat percentage in overweight sedentary women. Subjects were divided into 2 groups, the experimental (EXP) group (n = 10) and the control (CON) group (n = 10). The EXP group was using an ergo cycle of 10 sets, consisting of 60 s at 80-90% HRmax (cycling ∼120 rpm) and 60 s of active resting (cycling ∼40 rpm), intermittently. Blood serum and body fat percentage were measured before treatment and after 60 min of treatment. The results showed the serum irisin level was insignificant differences between EXP and CON groups. However, there was a significant decrease of irisin level between pre- and post-data in both EXP and CON, and the significant decrease of it between pre and post was in control group (EXP 6.65 ± 0.767 vs 5.76 ± 0.825, ; CON 7.46 ± 1.659 vs 5.80 ± 0.935 ng/ml, ). The change in body fat percentage was significant lower in EXP compared to CON (0.30 ± 0.217; 0.23 ± 0.118%; ). The conclusion is that the acute effect of HIIE can maintain the irisin level, and may also maintain the burning of body fat, which will lead to the reduction of body fat.
Spielräume des Übersetzens
Authors: Schmitt Christian 
Published: February 2024

Abstract
This article discusses the relationship of Sibylla Schwarz’ poem Verachtung der Welt and its Dutch source: passages from Jacob Cats’ book Houwelyck (1625), a kind of guide to marriage for the Dutch bourgeoisie. Previous research was not able to identify this source, partly because Schwarz takes a very unique approach with her adaptation. A comparative analysis of the texts brings Schwarz’ translation strategies into the foreground, which in turn demands a reevaluation of conclusions and assumptions about her work that until now have gone mostly unquestioned. The comparative analysis also reveals how skillfully Schwarz was able to make use of the Early Modern ‘spaces’ of translation, as she inscribes a new poetic dimension into Cats’ text.
The neural oscillations serving task switching are altered in cannabis users
Authors: McDonald Kellen M , Schantell Mikki , Horne Lucy K , John Jason A , Rempe Maggie P , Glesinger Ryan , Okelberry Hannah J , Coutant Anna T , Springer Seth D , Mansouri Amirsalar , Embury Christine M , Arif Yasra , Wilson Tony W 
Published: February 2024

Background: Regular cannabis is known to impact higher-order cognitive processes such as attention, but far less is known regarding cognitive flexibility, a component of executive function. Moreover, whether such changes are related to aberrations in the neural oscillatory dynamics serving flexibility remains poorly understood. Aims: Quantify the neural oscillatory dynamics serving cognitive flexibility by having participants complete a task-switching paradigm during magnetoencephalography (MEG). Probe whole-brain maps to identify alterations in chronic cannabis users relative to nonusers and determine how these alterations relate to the degree of cannabis use involvement. Methods: In all, 25 chronic cannabis users and 30 demographically matched nonuser controls completed neuropsychological testing, an interview regarding their substance use, a urinalysis, and a task switch paradigm during MEG. Time-frequency windows of interest were identified using a data-driven statistical approach and these were imaged using a beamformer. Whole-brain neural switch cost maps were computed by subtracting the oscillatory maps of the no-switch condition from the switch condition per participant. These were examined for group differences. Results: Cannabis users had weaker theta switch cost responses in the dorsolateral and dorsomedial prefrontal cortices, while nonusers showed the typical pattern of greater recruitment during switch relative to no switch trials. In addition, theta activity in the dorsomedial prefrontal cortex was significantly correlated with cannabis use involvement. Conclusions: Cannabis users exhibited altered theta switch cost activity compared to nonusers in prefrontal cortical regions, which are critical for cognitive flexibility. This activity scaled with cannabis use involvement, indicating a link between cannabis use and aberrant oscillatory activity underlying cognitive flexibility.
A nomogram to predict the risk of surgery-related pressure ulcers in patients undergoing cardiovascular surgery
Authors: Wei Xin , Xu Xiaoqing , Chen Yuan 
Published: February 2024

Objective In this study, we aimed to establish a new nomogram score to predict the occurrence of surgery-related pressure ulcers (SRPU) in patients undergoing cardiovascular surgery. Methods We conducted a retrospective study among patients who underwent cardiovascular surgery between February 2016 and November 2020. Results We established a prediction model based on a logistic regression model and tested the calibration and discrimination. We included 1163 patients who had undergone cardiovascular surgery. We formulated the logistic regression model, with Logit(P) = −11.745 + 0.024 preoperative hemoglobin value + 0.118 serum sodium value − 0.014 prealbumin value − 0.213 intraoperative mean temperature − 0.058 minimum mean arterial pressure + 0.646 preoperative blood potassium value + 0.264 smoking frequency + 0.760 hypertension history + 0.536 age ≥70 years. In this model ,“+” indicates that the factor is positively related to the occurrence risk of SRPU and “−” indicates that the factor is negatively associated with SRPU risk. The predictive model and nomogram had good accuracy in estimating the risk of SRPU, with a C-index of 0.755 (95% confidence interval: 0.719–0.792). Conclusions The present model can be used to effectively screen patients with a high risk of SRPU to devise targeted nursing intervention strategies and ultimately reduce the incidence rate of SRPU.
MR-based Bony 3D models enable radiation-free preoperative patient-specific analysis and 3D printing for SCFE patients
Authors: Lerch Till D , Kaim Tilman , Grob Valentin , Hanke Markus , Schmaranzer Florian , Steppacher Simon D , Busch Jasmin D , Ziebarth Kai 
Published: February 2024

Objectives: Slipped capital femoral epiphyses (SCFE) is a common pediatric hip disease with the risk of osteoarthritis and impingement deformities, and 3D models could be useful for patient-specific analysis. Therefore, magnetic resonance imaging (MRI) bone segmentation and feasibility of 3D printing and of 3D ROM simulation using MRI-based 3D models were investigated. Methods: A retrospective study involving 22 symptomatic patients (22 hips) with SCFE was performed. All patients underwent preoperative hip MR with pelvic coronal high-resolution images (T1 images). Slice thickness was 0.8–1.2 mm. Mean age was 12 ± 2 years (59% male patients). All patients underwent surgical treatment. Semi-automatic MRI-based bone segmentation with manual corrections and 3D printing of plastic 3D models was performed. Virtual 3D models were tested for computer-assisted 3D ROM simulation of patients with knee images and were compared to asymptomatic contralateral hips with unilateral SCFE (15 hips, control group). Results: MRI-based bone segmentation was feasible (all patients, 100%, in 4.5 h, mean 272 ± 52 min). Three-dimensional printing of plastic 3D models was feasible (all patients, 100%) and was considered helpful for deformity analysis by the treating surgeons for severe and moderate SCFE. Three-dimensional ROM simulation showed significantly (p < 0.001) decreased flexion (48 ± 40°) and IR in 90° of flexion (–14 ± 21°, IRF-90°) for severe SCFE patients with MRI compared to control group (122 ± 9° and 36 ± 11°). Slip angle improved significantly (p < 0.001) from preoperative 54 ± 15° to postoperative 4 ± 2°. Conclusion: MRI-based 3D models were feasible for SCFE patients. Three-dimensional models could be useful for severe SCFE patients for preoperative 3D printing and deformity analysis and for ROM simulation. This could aid for patient-specific diagnosis, treatment decisions, and preoperative planning. MRI-based 3D models are radiation-free and could be used instead of CT-based 3D models in the future.
Financial Inclusion and Economic Growth: Comparative Panel Evidence from Developed and Developing Asian Countries
Authors: Hussain Shahzad , Rehman Ajid ur , Ullah Sabeeh , Waheed Abdul , Hassan Shoaib 
Published: February 2024

We investigate the empirical nexus between financial inclusion and economic growth for an extended sample of 21 Asian countries spanning over a period from 2004 to 2019. Further, we also conducted a sub-sample analysis by dividing the overall samples into developed and developing countries. Our results reveal a significant positive long-term impact of financial inclusion on economic growth in Asia. Our pair-wise causality test shows bidirectional causality between financial inclusion and economic development. Our robust results are consistent across various estimation techniques. Our findings suggest that the influence of financial inclusion on economic growth is more pronounced in developing countries compared to developed countries. Our results hold across subsamples. These findings posit important policy insights to enable the policy-makers in designing policies that ensure efficient and inclusive financial system on an equitable basis to achieve sustainable economic growth. JEL classification: O16; O57; C38; C33
The Evidence for the Use of Osteobiologics in Hybrid Constructs (Anterior Cervical Discectomy and Fusion and Total Disc Replacement) in Multilevel Cervical Degenerative Disc Disease: A Systematic Review
Authors: Hoelen Thomay-Claire A. , Willems Paul C. , Loenen Arjan , Meisel Hans Jörg , Wang Jeffrey C. , Jain Amit , Buser Zorica , Arts Jacobus J. ,   AO Spine Knowledge Forum Degenerative
Published: February 2024

Study Design Systematic review Objective Examine the clinical evidence for the use of osteobiologics in hybrid surgery (combined anterior cervical discectomy and fusion (ACDF) and total disc replacement (TDR)) in patients with multilevel cervical degenerative disc disease (DDD). Methods PubMed and Embase were searched between January 2000 and August 2020. Clinical studies investigating 18-80 year old patients with multilevel cervical DDD who underwent hybrid surgery with or without the use of osteobiologics were considered eligible. Two reviewers independently screened and assessed the identified articles. The methodological index for non-randomized studies (MINORS) tool and the risk of bias (RoB 2.0) assessment tool were used to assess risk of bias. The Grading of Recommendations, Assessment, Development and Evaluations (GRADE) was used to evaluate quality of evidence across studies per outcome. Results Eleven studies were included. A decrease in cervical range of motion was observed in most studies for both the hybrid surgery and the control groups consisting of stand-alone ACDF or TDR. Fusion rates of 70-100% were reported in both the hybrid surgery and control groups consisting of stand-alone ACDF. The hybrid surgery group performed better or comparable to the control group in terms of adjacent segment degeneration. Studies reported an improvement in visual analogue scale for pain and neck disability index values after surgery compared to preoperative scores for both treatment groups. The included studies had moderate methodological quality. Conclusions There is insufficient evidence for assessing the use of osteobiologics in multilevel hybrid surgery and additional high quality and controlled research is deemed essential.
Complications With Demineralized Bone Matrix, Hydroxyapatite and Beta-Tricalcium Phosphate in Single and Two-Level Anterior Cervical Discectomy and Fusion Surgery
Authors: Cabrera Juan P. , Muthu Sathish , Mesregah Mohamed Kamal , Rodrigues-Pinto Ricardo , Agarwal Neha , Arun-Kumar Viswanadha , Wu Yabin , Vadalà Gianluca , Martin Christopher , Wang Jeffrey C. , Meisel Hans Jörg , Buser Zorica ,   AO Spine Knowledge Forum Degenerative
Published: February 2024

Study Design Systematic literature review. Objectives To analyze the evidence available reporting complications in single or two-level anterior cervical discectomy and fusion (ACDF) using a demineralized bone matrix (DBM), hydroxyapatite (HA), or beta-tricalcium phosphate (β-TCP). Methods A systematic review of the literature using PubMed, EMBASE, Cochrane Library, and ClinicalTrials.gov databases was performed in August 2020 to identify studies reporting complications in one or two-level ACDF surgery using DBM, HA, or β-TCP. The study was reported following the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. Results A total of 1857 patients were included, 981 male and 876 female, across 17 articles; 5 prospective, and 12 retrospectives. We noted heterogeneity among the included studies concerning the study design and combination of graft materials utilized in them. However, we noted a higher incidence of adjacent segment disease (17.7%) and pseudoarthrosis (9.3%) in fusion constructs using DBM. Studies using β-TCP reported a higher incidence of pseudoarthrosis (28.2%) and implant failures (17.9%). Conclusions Degenerative cervical conditions treated with one or two-level ACDF surgery using DBM, HA, or β-TCP with or without cervical plating are associated with complications such as adjacent segment disease, dysphagia, and pseudarthrosis. However, consequent to the study designs and clinical heterogeneity of the studies, it is not possible to correlate these complications accurately with any specific graft material employed. Further well-designed prospective studies are needed to correctly know the related morbidity of each graft used for achieving fusion in ACDF.