bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analytical Method Development and Validation of Propranolol and Hydrochlorothiazide
Authors: Golchha Darshna , B.Rajkamal  
Published: February 2024

Abstract
The active pharmaceutical components of Propranolol and Hydrochlorothiazide in their bulk dosage forms were to be measured using a unique, straightforward, responsive, and stable RP- HPLC method that was being developed and gradually validated. For the quantitative determination of Propranolol and Hydrochlorothiazide, a straightforward, specific, verified, and well-defined stability that exhibits gradient RP-HPLC approach has been developed. The Waters C18 column (150mm×4.6mm, 5mm particle size) was used for the chromatographic method, which involved isocratic elution with a mobile phase made up of orthophosphoric acid (0.1%) and acetonitrile (40:60% v/v). The instrument parameters called for a flow rate of 1 ml/min and a detection wavelength of 265 nm using the UV detector. The chromatographic method was expedited using the impurity-spiked solution. The proposed method's validity was examined in accordance with the international conference on harmonization (ICH) guidelines. The plotted calibration charts had linear regression coefficients of 0.999, indicating that their linearity was within acceptable bounds. The suggested approach is quick, easy, practical, and reasonably priced. It can be used for routine manufacturing sample analysis during stability tests and to confirm the caliber of medication samples during stability studies.
Low-temperature crystallization of kumdykolite, a polymorph of albite, during mineral carbonation within fluid inclusions in hornblendite from the Dabie orogen, central China
Authors: Zhang Long , Wang Qiang , Xian Haiyang , Ding Xing , Li Wan-Cai , Yang Yiping 
Published: February 2024

Abstract
Kumdykolite is a polymorph of albite that has been predominantly identified within crystallized melt inclusions in high-temperature metamorphic rocks. This study reports a new occurrence of kumdykolite that formed during internal mineral carbonation within amphibole-hosted fluid inclusions in post-collisional hornblendite from the Dabie orogen, central China. Amphibole in the hornblendite trapped CO2-rich fluid inclusions at the magmatic stage, and mineral carbonation, referring to the reaction of mineral rich in divalent cations and CO2 into carbonate, occurred in situ within the fluid inclusions due to the interaction between trapped CO2-rich fluids and host amphibole during cooling of the hornblendite. Kumdykolite was produced along with calcite, dolomite, chlorite, talc, a SiO2 phase (quartz or cristobalite), a TiO2 phase (rutile or anatase), and mica during internal mineral carbonation within the fluid inclusions. It is estimated that kumdykolite in the fluid inclusions crystallized under near-surface conditions, which are significantly different from the conditions of crystallization proposed in previous studies. It is further inferred that kumdykolite may crystallize metastably across the stability field of albite, and the presence of kumdykolite is not indicative of extreme thermobaric and fluid-absent conditions.
Effects of a Game Therapy program with Leap Motion Sensor on the Manual Function in Adults with Cerebral Palsy
Authors: Kintschner Natália Regina , Corrêa Ana Grasielle Dionísio , Figueiredo Paloma Sena Ferreira , Cymrot Raquel , Blascovi-Assis Silvana Maria 
Published: February 2024

Hand motor rehabilitation programs require long-term therapy and they are generally uninteresting and repetitive for the patient who is not always motivated to achieve them. The literature shows that Virtual Reality (VR) can increase motivation and engagement in motor rehabilitation programs. The aim of this study was to evaluate the effects of game therapy program for adults with cerebral palsy. The study included five adults with CP, levels 3 and 4 from Manual Ability Classification System (MACS). The manual function was evaluated before and after the game programs by the Box and Blocks and Jebsen-Taylor tests. The program was offered in 15 sessions, twice a week, in a care association for people with CP. The results indicated the stability of the condition, which can be expected for the adult population. Some games were more motivating and through testimonials, participants demonstrated satisfaction and suggested technical changes for better usability of the games. Motivators therapeutic resources should be considered in adult therapy with CP.
Limnological dynamics of methane (CH4) and carbon dioxide (CO2) emissions from a tropical hypertrophic reservoir lake
Authors: Gerardo-Nieto Oscar , Merino-Ibarra Martin , Sánchez-Carrillo Salvador , Guzmán-Arias Andrea P. , Castillo-Sandoval Fermín S. , Barjau-Aguilar Mariel , Valdespino-Castillo Patricia M. , Lestayo-González Julio A. , Díaz-Valenzuela Julio , Ramírez-Zierold Jorge Alberto , Thalasso Frédéric 
Published: February 2024

ABSTRACT
Methane (CH4) and carbon dioxide (CO2) emissions from tropical freshwater ecosystems have been understudied, particularly in terms of their interaction with limnological dynamics, their cycling, and the emission mechanisms of CH4. To help reduce that knowledge gap, this study addressed these processes in Valle de Bravo (VB), a tropical (19° 11. 65′ N) reservoir lake, that provides water supply to Mexico City metropolitan area. CH4 and CO2 concentrations and emissions from VB were measured during four field campaigns distributed along the annual limnological cycle of the reservoir. Dissolved CH4 concentration varied over four orders of magnitude (0.015–176.808 μmol L−1), and dissolved CO2 varied from below atmospheric saturation (15.062 μmol L−1) to 10 times that concentration (219.505 μmol L−1). CH4 fluxes ranged from 23.25 to 1220.80 μmol m−2 day−1, while CO2 fluxes ranged from −60.11 to 254.99 mmol m−2 day−1. Seasonal monitoring also allowed the assessment of the annual emissions as well as the greenhouse gas (GHG) storage during thermal stratification, which accounted for &gt;58% of the total GHG annual emissions from VB. Overall, VB is a source of GHG, and its major contribution is the CH4 released during the autumn overturn.
7 Tesla MRI Liver Fat Quantification in Mice: Data Quality Assessment
Authors: Polei Stefan , Lindner Tobias , Abshagen Kerstin , Liebig Marie , Krause Bernd J. , Vollmar Brigitte , Weber Marc-André 
Published: February 2024

Purpose::
The objective of this study was to evaluate the robustness of proton density fat fraction (PDFF) data determined by magnetic resonance imaging
(MRI) and spectroscopy (MRS) via spatially resolved error estimation.

Materials and Methods::
Using standard T2* relaxation time measurement protocols, in-vivo and ex-vivo MRI data with water and fat nominally in phase or out of phase
relative to each other were acquired on a 7 T small animal scanner. Based on a total of 24 different echo times, PDFF maps were calculated in a
magnitude-based approach. After identification of the decisive error-prone variables, pixel-wise error estimation was performed by simple
propagation of uncertainty. The method was then used to evaluate PDFF data acquired for an explanted mouse liver and an in vivo mouse liver
measurement.

Results::
The determined error maps helped excluding measurement errors as cause of unexpected local PDFF variations in the explanted liver. For in vivo
measurements, severe error maps gave rise to doubts in the acquired PDFF maps and triggered an in-depth analysis of possible causes, yielding
abdominal movement or bladder filling as in vivo occurring reasons for the increased errors.

Conclusion::
The combination of pixel-wise acquisition of PDFF data and the corresponding error maps allows for a more specific, spatially resolved evaluation
of the PDFF value reliability.
Enhanced Regularized Ensemble Encoderdecoder Network for Accurate Brain
Tumor Segmentation
Authors: Asiri Abdullah A. , Shaf Ahmad , Ali Tariq , Shakeel Unza , Irfan Muhammad , Alqahtani Saeed , Mehdar Khlood M. , Halawani Hanan T. , Alghamdi Ali H. , Alshamrani Abdullah Fahad A. , Mashraqi Aisha M. 
Published: February 2024

Background::
Segmenting tumors in MRI scans is a difficult and time-consuming task for radiologists. This is because tumors come in different shapes, sizes,
and textures, making them hard to identify visually.

Objective::
This study proposes a new method called the enhanced regularized ensemble encoder-decoder network (EREEDN) for more accurate brain tumor
segmentation.

Methods::
The EREEDN model first preprocesses the MRI data by normalizing the intensity levels. It then uses a series of autoencoder networks to segment
the tumor. These autoencoder networks are trained using back-propagation and gradient descent. To prevent overfitting, the EREEDN model also
uses L2 regularization and dropout mechanisms.

Results::
The EREEDN model was evaluated on the BraTS 2020 dataset. It achieved high performance on various metrics, including accuracy, sensitivity,
specificity, and dice coefficient score. The EREEDN model outperformed other methods on the BraTS 2020 dataset.

Conclusion::
The EREEDN model is a promising new method for brain tumor segmentation. It is more accurate and efficient than previous methods. Future
studies will focus on improving the performance of the EREEDN model on complex tumors.
Impact of Digital Influencers on Portuguese Consumers in the Beauty Industry
Authors: Santos Bárbara , Bernardes Óscar , Amorim Vanessa 
Published: February 2024

Abstract
Digital influencers can reach multiple consumers through their platforms, such as Facebook and Instagram. In this sense, the objective of our study is to explore Influence Marketing in Portugal in the cosmetic industry and the way digital influencers can have an impact on the behavior of portuguese consumers. To explore the benefits of using digital influencers as a marketing tool, the mode of action and the impact on consumer behavior, we resort to the use of qualitative methodology. In this sense, our study consists of a case study, namely, the case of Nyx Cosmetic. The use of “digital influencers” as a marketing tool has shown a positive impact on consumer behavior due to its influence on followers, which is also seen in the Portuguese cosmetic market. Due to the continuous increase of users of portuguese social networks, brands must have a strong online presence to create an impact on their current and potential consumers.

Keyword: Cosmetics; digital influencers; marketing; nyx Cosmetic.
Política neoliberal na educação superior sob Fernando Henrique Cardoso: estratégias e marcos decisórios
Authors: Baron Jaime , De Oliveira Roza da Cruz Solange 
Published: February 2024

Este artigo tem como objetivo desvelar como se deu o foco da política educacional para o Ensino Superior do governo Fernando Henrique Cardoso na expansão da educação superior pela via privada, tendo como base a flexibilização da oferta educativa através de um novo marco legal que passou a orientar as IES pela lógica do mercado e tem como respaldo um sistema regulatório apoiado na avaliação, que visa preservar um padrão mínimo de qualidade para o ensino oferecido. No caso das instituições públicas, a contenção do financiamento e a sua vinculação a indicadores de resultado e o estímulo à busca de fontes alternativas de recursos objetiva uma maior racionalização no uso dos recursos públicos. O trabalho utilizou-se essencialmente de revisão da literatura sobre o assunto e de pesquisa documental na legislação pertinente e com base nas leituras efetuadas chegou-se à compreensão de que as ações do governo Fernando Henrique Cardoso no universo do Ensino Superior no Brasil foram guiadas pelo viés neoliberal que marcou o seu governo. O resultado dessa política foi um aumento expressivo das matrículas presenciais no Ensino Superior, ampliação esta sustentada basicamente pelas instituições privadas, que ampliaram significativamente sua participação no total das matrículas em detrimento das públicas (especialmente as federais).
Breaking Dormancy of Shallot (Allium ascolonicum L.) Bulb Using Hydrogen Peroxide
Authors: Nurfaida Nurfaida , Syam'un Elkawakib , Ulfa Fachirah , Mantja Katriani , Faried Muhammad 
Published: February 2024

Shallot bulbs have a dormancy period, so they must be stored for 3-4 months. This condition inhibits the acceleration of planting, which has a short time, so efforts are needed to accelerate the dormancy period by using hydrogen peroxide. This research was carried out from June to July 2023 at the Screen House, Teaching Farm, Faculty of Agriculture, Hasanuddin University. The study was arranged in a randomized block design with a two-factor factorial design. The first factor is the variety of Mentes, Rubaru, Violetta 2 Agrihorti, Kramat 1, and Ambassador 3 Agrihorti. The second factor is hydrogen peroxide concentration with three levels, namely 0%, 10% and 20%. The results showed that breaking the dormancy of shallot bulbs using hydrogen peroxide at a concentration of 20% effectively triggered the process of bulb growth in the various shallot varieties tested, marked by an increase in the percentage of rooted and sprouted bulbs. The Rubaru and Mentes varieties had an excellent response to 20% hydrogen peroxide immersion, indicated by a shorter rooting and sprouting time, compared to other varieties and concentrations of hydrogen peroxide. Therefore, hydrogen peroxide with a concentration of 20% can be used to break dormancy in shallot bulbs. However, further studies are needed on growth and production in the field and the quality and safety of shallot bulbs. Keywords: Bulb, Dormancy, Hydrogen peroxide, Shallot.
Mikä HPV-rokotuksessa pelottaa
Authors: Kero Katja , Paavonen Jorma 
Published: February 2024

Tiivistelmä
HPV-rokotteen kehittäminen ja käyttöönotto on ollut menestystarina luoden toivoa HPV-infektion ja siihen liittyvien kalliiden ja inhimillistä kärsimystä aiheuttavien sairauksien juurimiseksi maailmasta. Suomessa kaikille lapsille ja nuorille tarjotaan yhdenvertaisesti oikeus HPV-rokotteeseen. Huolimatta Terveyden ja hyvinvoinninlaitoksen ansiokkaasta HPV-rokotustiedotuksesta rokotuskattavuutemme jää EU:n ja WHO:n asettamia tavoitteita selvästi pienemmäksi. Rokotuskattavuudessa on myös huomattavia alueellisia eroja. Korkea rokotuskattavuus olisi kuitenkin ensiarvoisen tärkeää hyvän laumasuojan saavuttamisessa. Tarkoituksellisesti väärän, vailla tieteellistä näyttöä olevan tiedon levittäminen aiheuttaa ymmärrettävää hämmennystä lapsissa, nuorissa ja heidän vanhemmissaan. Terveydenhuollon ammattilaisten, tutkijoiden ja viranomaisten rooli on keskeinen taistelussa disinformaatiota vastaan. Voimme lisätä rokotekattavuutta tehokkaalla vastuullisella viestinnällä, luotettavan tiedon jakamisella ja yhteistyöllä.
PENCITRAAN DAN PEMAJASAN TERHADAP NOVEL “99 CAHAYA DI LANGIT EROPA” KARYA HANUM SALSABIELA RAIS DAN RANGGA ALMAHENDRA
Authors: Anjarsari Riana 
Published: February 2024

Karya sastra selalu menjadi pembicaraan yang sangat menarik sampai saat ini khususnya novel. Penelitian ini bertujuan untuk mendeskripsikan pencitraan dan pemajasan dalam novel 99 Cahaya di Langit Eropa karya Hanum Salsabiela Rais dan Rangga Almahendra. Jenis penelitian ini kualitatif deskriptif. Subjek dalam penelitian ini pencitraan dan pemajasan. Objek dalam penelitian ini novel 99 Cahaya di Langit Eropa karya Hanum Salsabiela Rais dan Rangga Almahendra. Sumber data yakni teks yang ada dalam novel 99 Cahaya di Langit Eropa karya Hanum Salsabiela Rais dan Rangga Almahendra berupa narasi, dialog, maupun kalimat. Teknik pengumpulan data dalam penelitian ini kepustakaan.
Hasil peneilitian yang diperoleh yakni; 1) Bentuk pencitraan yang terdapat dalam novel 99 Cahaya di Langit Eropa karya Hanum Salsabiela Rais dan Rangga Almahendra yaitu citraan penglihatan, citraan pendengaran, dan citraan penciuman. Jenis pencitraan yang dominan dalam novel 99 Cahaya di Langit Eropa karya Hanum Salsabiela Rais dan Rangga Almahendra adalah citraan penglihatan. 2) Bentuk pemajasan yang terdapat dalam novel 99 Cahaya di Langit Eropa karya Hanum Salsabiela Rais dan Rangga Almahendra yaitu majas metafora, majas personifikasi, dan majas simile. Jenis pemajasan yang dominan dalam novel 99 Cahaya di Langit Eropa karya Hanum Salsabiela Rais dan Rangga Almahendra adalah majas.
THE ROLE OF PARENTS IN INCREASING THE ENTHUSIASM FOR LEARNING OF CLASS IV STUDENTS
Authors: Sulistyowati Kintoko Aldi Saputra , Abduh Muhammad 
Published: February 2024

Abstract
The learning process is important in achieving success in education. One of the learning process elements that influences learning achievement is family support, especially parents. This research aims to describe the role of parents in increasing students' enthusiasm for learning in class IV of SD Negeri 1 Simo. The method used was analytical descriptive with a qualitative approach. Data collection techniques in this research were observation and interviews. Observation was conducted at SD Negeri 1 Simo, especially for 34 students of class IV. Interviews were carried out with three sources, namely students, teachers, and parents, based on several indicators of enthusiasm for learning. The research results indicated that the role of parents influences students' enthusiasm for learning. Their efforts to increase students’ enthusiasm can make it easier for them to learn, such as providing adequate learning facilities, giving rewards to their children, maintaining harmonious conditions at home, and giving encouragement and advice. The implications of these findings can be used as a reference for parents in educating their children to improve achievements at school.
COMICS AS AN INTERESTING INDONESIAN LANGUAGE LEARNING MEDIA FOR SD/MI STUDENTS
Authors: Ridzal Diana Falhabibah Saifur , Mislikhah St. , Mu’alimin  
Published: February 2024

Abstract
Comics are a series of images created as a learning medium for conveying information. Comic teaching materials are tools used by teachers or instructors in the teaching-learning process to convey information through pictures following stories. The main purpose of this research was to analyze comics as an interesting medium for learning Indonesian Language in elementary school (SD/MI) students. The research method used was library research. The data sources in this research were previous research findings from both national and international journals. The literature reviews were based on existing literature and documentation data. Data analysis from the results of literature and research using qualitative analysis started with data reduction, display, conclusion, and data verification. The research results showed that the use of comics as a learning medium was very suitable for helping students, especially SD/MI students, to understand and achieve the goals of learning Indonesian language. However, it needs to prepare teaching materials in comic form. The images in comics must be arranged carefully so as not to make information overwhelm students' imaginations. Various images in comics help students gain an understanding of the objectives to be achieved in the subject. Therefore, learning media in the form of comics can be used as an alternative to Indonesian language learning process for elementary students.
THE EFFECT OF REALIA MEDIA BASED ON REALISTIC MATHEMATICS EDUCATION ON NUMERACY LITERACY ABILITY
Authors: Suryaningsih Tri , Edwita  , Gusti Yarmi  
Published: February 2024

Abstract
Numeracy skills at elementary schools play an essential role as a fundamental foundation for students in developing logical thinking, problem-solving, and mathematical skills needed to face the complexity of technological developments. This study aims to investigate the effect of using Realistic Mathematics Education (RME)-based realia media on numeracy literacy skills in Class IV students at SD Negeri Gandaria Utara 03 South Jakarta. The research method applied was a quasi-experiment. The sample consisted of IVA class students as the experimental class and IVB class students as the control class, which were selected using simple random sampling. The research instrument was a test consisting of 6 essays. The research results showed that using RME-based realia media had a significant effect on students' numeracy literacy skills. Thus, teachers can consider the use of RME-based realia media as an effective teaching tool to improve students' numeracy literacy skills. The main implication of this research is the importance of using realia in learning mathematics. Teachers and educators can utilize real and textual objects in teaching mathematical concepts to help students understand them better.
نقد طه حسين على الشعر الجاهلي ومساهمته في الدراسة الأدبية
Authors: Kartono Akhmad Fadhillah , Haniah Haniah , Hamzah Andi Abdul , Gadalla Mohamed Saad Abdelkhalk 
Published: February 2024

هذه الدراسة تهدف إلى تحليل نقد طه حسين على الشعر الجاهلي، والطرق التي سلك بها هذا الأديب في نقده وذلك لسحب مساهمته في الدراسة الأدبية. قام الباحث في هذه الدراسة بمنهج تحليل المحتوى بتحليل آراء طه حسين النقدي في مؤلفاته والنظر إلى أراء العلماء عنه المنشورة في المصنفات، ولجمع البيانات يستخدم الباحث منهج البحث المكتبي أو استطلاع الكتب فمن ثم يتم بسرد المعلومات وتصنيف البيانات لتفسيرها مستخدما منهج تحليل الاستنتاج والاستقراء. توصل البحث إلى أن طه حسين قد شك في أصالة الشعر الجاهلي وأكد أن أكثرها منحولة بعد ظهور الإسلام، وقد نهج منهجالمستشرقين في أغلب آرائه حول الشعر الجاهلي حتى شك في قيمة الأدب الجاهلي كما ابتغى إلى إعادة الإنتاج الثقافي العربي والثورة والتجديد من خلال دعوته. ولقد قدم مقتربًا اجتماعيًا ومنهجًا علميًا في دراسته للتاريخ، وإن ذلك المنهج العلمي التاريخي، والمذهب الاجتماعي في تفسير التاريخ هما الأساس والجوهر لمساهمته الفكرية الكبرى في الحياة الفكرية العربية المعاصرة.
Abstract
This article aims to analyze Taḥa Ḥusayn's criticism of pre-Islamic poetry, the methods he used in his criticism, and his contribution to literary studies. The researcher used a descriptive approach to analyze several texts from the opinions of scholars published in books. The data was collected using a library research method or book survey. The data was then classified and interpreted using deductive and inductive analysis. Taḥa Ḥusayn followed the path of Orientalists in most of his views on pre-Islamic poetry, even questioning the value of pre-Islamic literature. He also sought to revive Arab cultural production and revolutionize and renew it through his call. Before criticizing the poetry of any poet, Taḥa Ḥusayn called for knowing the poet's personality and understanding the environment in which he lived. These are the circumstances surrounding the poet that affect his poetry. Therefore, there is something very important in criticism, which is the artistic pleasure of enjoying the text. Regardless of the controversies surrounding this writer, we should not forget that he was a great writer, even known as the Dean of Literature. This title is only given to the best of people. This is what arouses the need to review the contribution of this writer to literary studies, which his previous scholars did not pay attention to or mentioned only a small part of it.