bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validation of the VisionArray® Chip Assay for HPV DNA Testing in Histology Specimens of Oropharyngeal Squamous Cell Carcinoma
Authors: Channir Hani Ibrahim , Bendtsen Simone Kloch , Melchior Linea Cecilie , Sandholm Pia Rovsing , Mordhorst Christine , Carlander Amanda-Louise Fenger , von Buchwald Christian , Kiss Katalin 
Published: March 2024

Abstract
Background
The detection of human papillomavirus (HPV) has several implications in the diagnostic work-up and management of oropharyngeal squamous cell carcinoma (OPSCC). The choice of HPV detection assay and testing algorithms differ across institutions and vary in cost, detection targets, technical feasibility, and turnaround time. In this study, we aimed to validate the VisionArray® HPV Chip for formalin-fixed and paraffin-embedded (FFPE) samples of OPSCC using the previously applied standard pan-HPV DNA PCR assay as a reference.

Methods
The validation cohort consisted of FFPE tissue samples from patients previously diagnosed with HPV DNA-positive OPSCC (n = 80), HPV DNA-negative OPSCC (n = 21), and a benign group of tumor samples consisting of Warthin’s tumors (n = 20) and branchial cleft cysts of the lateral neck (n = 14). All samples were tested with p16 immunohistochemistry, pan-HPV DNA PCR, and the VisionArray® HPV Chip.

Results
The overall sensitivity and specificity of the VisionArray® HPV Chip assay were 100% [95% CI 95.5%; 100.0%] and 96.3% [95% CI 87.3%; 99.6%] and the positive predictive value and negative predictive value were 97.6% [95% CI 91.5%; 99.7%] and 100% [95% CI 93.2%; 100%], respectively.

Conclusions
The VisionArray® HPV Chip assay can be recommended for high-risk HPV testing in FFPE tissue samples from OPSCC, providing both a fast and simultaneous genotyping for 41 clinically relevant HPV types.
Allogeneic hematopoietic stem cell transplantation after mogamulizumab in T-cell lymphoma patients: a retrospective analysis
Authors: Lechowicz Mary Jo , Smith Christy , Ristuccia Robert , Dwyer Karen 
Published: March 2024

AbstractAllogeneic hematopoietic stem cell transplantation (allo-HSCT) is an important therapy for patients with T-cell lymphomas, including cutaneous T-cell lymphoma (CTCL), adult T-cell lymphoma (ATL), and peripheral T-cell lymphoma (PTCL). Mogamulizumab is an anti-CCR4 antibody that has been associated with an increased risk of transplant-related complications in retrospective analyses of ATL, particularly when administered within 50 days before transplantation. This post hoc analysis of 3 clinical trials examined safety and outcome data for 32 patients with CTCL (n = 23), ATL (n = 7), or PTCL (n = 2) who underwent allo-HSCT after mogamulizumab treatment. Overall, 22 patients (69%) were known to have graft-versus-host disease (GVHD), 8 patients (25%) did not report GVHD, and 2 patients (6%) had unknown GVHD status. Fourteen patients with known GVHD underwent transplantation between 50 and 365 days after their last dose of mogamulizumab, while 2 underwent transplantation within 50 days after treatment. Based on this limited evidence, GVHD was not associated with the time interval from last mogamulizumab dose to transplantation.
Design and Control of a Flexure-Based Dual Stage Piezoelectric Micropositioner
Authors: Zarrabi Ekbatani Romina , Zheng Jinchuan , Chen Xiaoqi , Nikzad Mostafa , Man Zhihong 
Published: March 2024

AbstractIn the field of advanced manufacturing technology, there is a growing need for high-precision micro/nano positioners. The traditional single stage actuated positioners have encountered performance limitation in achieving longer travel range and higher precision. This motivates us to develop a novel dual stage piezoelectric-actuated micropositioner presented in this paper. The micropositioner incorporates displacement amplification mechanisms to overcome the limited range of piezoelectric actuators. Design considerations such as flexure characteristics and material selection are discussed, and structural analysis is performed using finite element analysis (FEA). For precise positioning, the dual stage control strategy is investigated and compared with the conventional proportional-integral-derivative (PID) single stage control method. In the proposed positioner, a combination of parallelogram and bridge mechanisms is utilized. The bridge mechanism works to amplify the piezoelectric actuator displacement output. The parallelogram mechanism, integrated within the system, helps mitigate resonance modes and contributes to the achievement of linearized motion. The characteristics of the micropositioner were evaluated using analytical modelling and FEA. Multiple analysis was used to optimise the positioner’s design parameters. Furthermore, experimental studies were carried out to validate the characteristics of the micropositioner performance in terms of achievable output travel range and sustained positioning accuracy.
Musculoskeletal health in esport: a cross-sectional comparison of musculoskeletal pain among young Danish esports players and handball players
Authors: Sand Hansen Frederik , Lyngs Mathias , Dyg Hyllested Lauridsen Mathias , Lund Straszek Christian 
Published: March 2024

Abstract
Purpose
There is a continuous debate regarding musculoskeletal (MSK) pain prevalence and training volume among amateur esports players. Previous findings suggest that MSK pain may limit esports participation in this group; however, these results have yet to be replicated in a similar population. It also remains to be investigated whether MSK pain is more prevalent in esports compared to other activities, such as handball. The objectives were (1) to compare MSK pain prevalence among amateur esports players and another group of sports-active amateur players and (2) to investigate whether MSK pain would impact training volume in the two groups.

Methods
Eligible players for this cross-sectional study had to engage in either structured esports or handball and be 15–25 years of age to participate. Demographic data, self-reported MSK pain prevalence, training volume, sleep patterns, physical activity level, and activity-limiting pain and burnout were obtained through online questionnaires.

Results
In total, 76 esports players and 175 handball players were included. Overall, 48% of esports players and 80% of handball players experienced MSK pain. The odds of experiencing MSK pain were significantly lower in esports compared to handball (OR: 0.24, 95% CI 0.13–0.43, chi-square p < 0.001). There was no significant difference in training volume between players with or without MSK pain in either group. Esports players had significantly higher training volume (additional 13 h/week, p < 0.001) compared to handball players.

Conclusion
These findings indicate that esports players are not at increased odds of experiencing MSK pain compared to handball players despite significant differences in training volume.
Gangue grouting filling in subsequent space of coal green mining: methodology and case study
Authors: Yu Kunpeng , Ma Liqiang , Ngo Ichhuy , Zhai Jiangtao , Xu Yujun , Zhao Zhiyang , Wang Hui , Wang Dangliang 
Published: March 2024

AbstractUnderground backfilling stands out as a crucial technological strategy for the eco-friendly and effective management of solid waste in mining operations. However, existing backfilling techniques have led to increased production processes at the working face, resulting in a reduction in coal extraction efficiency. Addressing the temporal and spatial interference between mine solid waste backfilling and coal mining is essential. To overcome this challenge, this study introduces a novel post-mining spatial gangue slurry backfilling method. Radar detection was employed to ascertain the typical characteristics of the subsequent space collapse roof shape. Stress monitoring and compaction experiments were conducted to establish the relationship between stress and the bulking coefficient of the overlying rock mass, identifying subsequent spatial void structure characteristics. The development of a CO2 mineralized coal-based solid waste filling material, utilizing conventional low-calcium fly ash under normal temperature and pressure conditions, was presented. This paper provides a comprehensive understanding of the post-mining spatial gangue slurry backfilling method, outlines the spatial layout approach for the corresponding system, and analyzes research challenges associated with gangue slurry backfilling materials and the technology of slurry injection borehole layout. The research aims to innovate an efficient underground disposal model for gangue, contributing to the refinement of the technical system for the comprehensive disposal and utilization of gangue.
Sclerotinia sclerotiorum is the causal agent of Sclerotinia stem rot on peanut (groundnut) in South Africa
Authors: Bornman Simoné , Thomas Chanel , Ntladi Solomon , Wilken P. Markus 
Published: March 2024

AbstractSclerotinia stem rot on South African groundnut was previously attributed to Sclerotinia minor, but recent infections prompted a re-evaluation. Isolates underwent a species-specific PCR and phylogenetic analysis, confirming them as S. sclerotiorum. Koch’s postulates were fulfilled, demonstrating pathogenicity. Inoculation caused disease symptoms, with subsequent re-isolation matching the original strains. This study identifies S. sclerotiorum as the causative agent of Sclerotinia stem rot on groundnut in South Africa.
Thermal boundary conditions for heat transfer analysis of bridges considering non-uniform distribution of internal air temperature by computational fluid dynamics
Authors: Zhang Lu , Shan Yushi , Li Lingfang , Wang Fei , Xia Yong 
Published: March 2024

AbstractHeat transfer analysis has been used to calculate the temperature distribution in bridges. Thermal boundary conditions play a critical role in this analysis. However, existing studies on thermal boundary conditions simplify the air temperature inside the bridge deck as uniform, which is not realistic and thus causes inaccurate simulation results. This study proposes a new approach to thermal boundary conditions in the heat transfer analysis of bridges. For the first time, computational fluid dynamics is used to calculate non-uniform air temperatures inside the bridge deck. In addition, non-approximate heat exchange equations for long-wave radiation are also incorporated into the approach. The techniques are applied to the 1377-m main span Tsing Ma Suspension Bridge to calculate the internal air temperatures of a deck segment. Transient heat transfer analysis is then conducted to calculate the time-dependent temperature distribution of the segment. As compared with the field monitoring results, the proposed approach can simulate the temperature distribution of the bridge with an average discrepancy of 0.88 °C and is more accurately than other existing approaches.
Multi-objective Optimization Framework for Trade-Off Among Pedestrian Delays and Vehicular Emissions at Signal-Controlled Intersections
Authors: Akyol Görkem , Göncü Sadullah , Silgu Mehmet Ali 
Published: March 2024

AbstractTraffic congestion has several adverse effects on urban traffic networks. Increased travel times of vehicles, with the addition of excessive greenhouse emissions, can be listed as harmful effects. To address these issues, transportation engineers aim to reduce private car usage, reduce travel times through different control strategies, and mitigate harmful effects on urban networks. In this study, we introduce an innovative approach to optimizing traffic signal control settings. This methodology takes into account both pedestrian delays and vehicular emissions. Non-dominated sorting genetic algorithm-II and Multi-objective Artificial Bee Colony algorithms are adopted to solve the multi-objective optimization problem. The vehicular emissions are modeled through the MOVES3 emission model and integrated into the utilized microsimulation environment. Initially, the proposed framework is tested on a hypothetical test network, followed by a real-world case study. Results indicate a significant improvement in pedestrian delays and lower emissions.
Engaging diverse voices across sites of curriculum making in Australia: realities and possibilities
Authors: Garrard Kerri Anne , Cairns Rebecca , Weinmann Michiko , Hannigan Shelley , Phillips Fiona 
Published: March 2024

Abstract
Research to date has pointed out that during periods of curriculum reform, public debate gets politicised resulting in an over-emphasis on top-down approaches to curriculum making. As a group of curriculum inquiry researchers, we are concerned that teachers, students, school leaders and community organisations are often side-lined as integral curriculum actors in curriculum making processes. This paper challenges top-down, discipline-siloed conceptualisations of curriculum making by bringing together three separate curriculum projects, as illustrations, for the purpose of rendering diverse articulations of curriculum as a social process. We apply Priestley et al.’s (Priestley et al., Curriculum making in Europe: Policy and practice within and across diverse contexts, Emerald Publishing Limited, 2021) sites of curriculum making as a conceptual frame, to articulate the diversity of curriculum making activities, curriculum actors and sites of curriculum making in primary and secondary settings. The three illustrations include examining how teachers and students participate in curriculum making about Asia and Australia’s engagement with Asia at macro and meso sites; how listening to secondary students as curriculum actors allows them to contribute to shaping school History beyond the nano sites of the classroom and how community and arts-based approaches empower primary students to engage in nano curriculum making (e.g. Hannigan & Kelly, Hannigan and Kelly, Lin et al. Sinner et al. Irwin (eds), Community arts education: Transversal global perspectives, Intellect, 2023). By engaging a collaborative approach that uses illustrations to draw a complementary transdisciplinary picture of the realities and possibilities of curriculum making across different sites, this paper makes a novel methodological contribution to the field of curriculum inquiry.
Examining the Relationships Among Adverse Experiences, Impulsivity, and Alcohol Use: A Scoping Review of Recent Literature
Authors: Wilson Sayre E. , Garcia Karla , Fava Nicole M. , Leeman Robert F. 
Published: March 2024

Abstract
Purpose of Review
Alcohol use and associated consequences are among the top preventable causes of death in the USA. Research links high impulsivity and adverse and traumatic experiences (ATEs) to increased alcohol use/misuse, as all three similarly affect brain functioning and development. Yet, studies measuring different specific domains yield differing results. This scoping review examined research articles (N = 35) that examine relations among domains of impulsivity, ATEs, and alcohol use.

Recent Findings
Overall, findings indicate that both childhood and lifetime ATEs and all three domains of impulsivity (generalized, choice, and action) are significantly associated with various alcohol and other concurrent substance use measures across age groups. However, variations in results indicate that factors such as timing of assessment, methods, and heterogeneity of construct domains are critical components of these relationships.

Summary
Several research gaps remain. Future research should incorporate multiple domains of the three constructs, and additional longitudinal studies are needed to determine the true nature of the relationships.
A note on complex plane curve singularities up to diffeomorphism and their rigidity
Authors: Fernández-Hernández A. , Giménez Conejero R. 
Published: March 2024

AbstractWe prove that if two germs of plane curves (C, 0) and $$(C',0)$$

(

C
′

,
0
)

with at least one singular branch are equivalent by a (real) smooth diffeomorphism, then C is complex isomorphic to $$C'$$

C
′

or to $$\overline{C'}$$

C
′

¯

. A similar result was shown by Ephraim for irreducible hypersurfaces before, but his proof is not constructive. Indeed, we show that the complex isomorphism is given by the Taylor series of the diffeomorphism. We also prove an analogous result for the case of non-irreducible hypersurfaces containing an irreducible component that is non-factorable. Moreover, we provide a general overview of the different classifications of plane curve singularities.
Semantic prior guided fine-grained facial expression manipulation
Authors: Xue Tao , Yan Jin , Zheng Deshuai , Liu Yong 
Published: March 2024

AbstractFacial expression manipulation has gained wide attention and has been applied in various fields, such as film production, electronic games, and short videos. However, existing facial expression manipulation methods often overlook the details of local regions in images, resulting in the failure to preserve local structures and textures of images. To solve this problem, this paper proposes a local semantic segmentation mask-based GAN (LSGAN) to generate fine-grained facial expression images. LSGAN is composed of a semantic mask generator, an adversarial autoencoder, a transformative generator, and an AU-intensity discriminator. Our semantic mask generator generates eye, mouth, and cheek masks of face images. Then, our transformative generator integrates target expression labels and corresponding facial region features to generate a vivid target facial expression image. In this fashion, we can capture expressions from target face images explicitly. Furthermore, an AU-intensity discriminator is designed to capture facial expression variations and evaluate quality of generated images. Extensive experiments demonstrate that our method achieves authentic face images with accurate facial expressions and outperforms state-of-the-art methods qualitatively and quantitatively.
Torsion phenomena for zero-cycles on a product of curves over a number field
Authors: Gazaki Evangelia , Love Jonathan 
Published: March 2024

AbstractFor a smooth projective variety X over an algebraic number field k a conjecture of Bloch and Beilinson predicts that the kernel of the Albanese map of X is a torsion group. In this article we consider a product $$X=C_1\times \cdots \times C_d$$

X
=

C
1

×
⋯
×

C
d

of smooth projective curves and show that if the conjecture is true for any subproduct of two curves, then it is true for X. For a product $$X=C_1\times C_2$$

X
=

C
1

×

C
2

of two curves over $$\mathbb {Q} $$
Q
with positive genus we construct many nontrivial examples that satisfy the weaker property that the image of the natural map $$J_1(\mathbb {Q})\otimes J_2(\mathbb {Q})\xrightarrow {\varepsilon }{{\,\textrm{CH}\,}}_0(C_1\times C_2)$$

J
1

(
Q
)

⊗

J
2

(
Q
)

→
ε

CH

0

(

C
1

×

C
2

)

is finite, where $$J_i$$

J
i

is the Jacobian variety of $$C_i$$

C
i

. Our constructions include many new examples of non-isogenous pairs of elliptic curves $$E_1, E_2$$

E
1

,

E
2

with positive rank, including the first known examples of rank greater than 1. Combining these constructions with our previous result, we obtain infinitely many nontrivial products $$X=C_1\times \cdots \times C_d$$

X
=

C
1

×
⋯
×

C
d

for which the analogous map $$\varepsilon $$
ε
has finite image.
Parent Preferences for Peer Connection in Virtual Mental Health and Parenting Support Platforms
Authors: Rioux Charlie , Childers-Rockey Zoe A. , Konkin Avaline , Cameron Emily E. , Tomfohr-Madsen Lianne , MacKinnon Anna L. , Watts Dana , Murray Julie , Pharazyn Ashley , Roos Leslie E. 
Published: March 2024

AbstractPeer connections can be integrated in online and app-based (eHealth) family mental health and parenting programs through forums/chats or video group sessions. Little is known about parental preferences regarding eHealth features, yet they could be key factors influencing uptake and utility of programs. Accordingly, the present study aims to examine parent preferences for connecting with other parents in eHealth programs. Parents (n = 177) of 0–5-year-old children in the United States were recruited on MTurk. Parents were asked about peer connection preferences through questions framed around how and with whom they would like to connect when using a virtual mental health and parenting support platform. Most (86.4%) preferred connecting with other parents in an eHealth program with 73.2% preferring to connect anonymously. If using a forum, 45.5% of mothers were comfortable connecting only with other mothers whereas 54.5% were comfortable connecting with parents of any gender; 80.3% of fathers were comfortable connecting with all parents. Results were similar for videoconferencing. Age, income, number of children, recent stressful events, social support, mental health symptoms, and parenting stress did not predict any of these preferences. Our results suggest that integrating peer connection should be considered in developing parental eHealth programs as it may be in line with the preferences of most parents and programs that match user preferences have been shown to have higher enrollment and adherence. These preferences should be further studied with community samples and diverse participants to strengthen confidence in the findings and properly inform program development.
A Study on the Weapon–Target Assignment Problem Considering Heading Error
Authors: Kim Ji-Eun , Lee Chang-Hun , Yi Mun Yong 
Published: March 2024

AbstractThe focus of this study is to investigate the assignment of weapons to multiple targets in a scenario, specifically when an air defense system is confronted with numerous targets, such as low-altitude rockets or groups of drones. The accuracy of weapons in destroying these targets depends heavily on the correct alignment of the launchers with the targets, which can be affected by errors in launcher orientation. Therefore, in solving weapon–target assignment (WTA) problems, it is crucial to account for the heading errors caused by the launcher’s orientation angle. To address this issue, the use of a rotation strategy to align the orientation angle with the target’s approach direction can significantly improve the probability of kill (PK) against the target. However, its unitary implementation has limitations, which may result in missed engagements if there is insufficient time to rotate to the desired orientation angle. Thus, as a remedy, we propose a new WTA method that combines rotation and rotation fix strategy, improving the weakness of losing the opportunity of engagement due to rotation time and heading errors. The efficacy of this approach is evaluated through numerical simulations.