bluuebunny/crossref_metadata_2025_split huggingface dataset:
Amsterdam as a Global City: Restructuring, Identity Rearticulation, and Resistance in the Service Sector
Authors: Dörfler Tobias , Marchand Marianne H. , Pirschner Claus 
Published: February 2006

AbstractThis article explores the interconnections between political‐economic transformations of Amsterdam into a second‐tier global city and the rearticulation of (gender) identities and resistance practices in the service sector. The research focuses on both the high and low ends of the service sector, i.e., banking and cleaning. Given different positionalities of employees in respective sectors, the article shows that their responses to changes in their work environment take on different modalities. Women managers in the banking sector resort to a strategy of “hiding” their gender identity and individualized responses, while Moroccan (male) cleaners tend to underscore the masculine nature of their work and are joining labor unions in greater numbers than before.
Cognitive behaviour therapy and medication in the treatment of obsessive–compulsive disorder
Authors: O'Connor K. P. , Aardema F. , Robillard S. , Guay S. , Pélissier M.‐C. , Todorov C. , Borgeat F. , Leblanc V. , Grenier S. , Doucet P. 
Published: February 2006

Objective:  To compare cognitive behaviour therapy (CBT) with CBT plus medication; medication alone; and placebo in the treatment of adult obsessive–compulsive disorder (OCD).Method:  Forty‐eight participants (43 completers) were recruited into two protocols. In the first protocol, 21 people with OCD were randomly allocated to either a standard medication (fluvoxamine) or standard placebo condition for a 5‐month period. Both these groups subsequently received CBT for a further 5 months. In the second protocol, 22 people with OCD received CBT, one group was already stabilized on an antidepressant of choice; the second group was drug naïve.Results:  All active treatments, but not the placebo, showed clinical improvement. There was no difference in treatment response to CBT regardless of whether participants had previously received medication or placebo.Conclusion:  CBT has a more specific antiobsessional effect than medication but CBT plus medication shows greatest overall clinical improvement in mood.
Laryngeal paralysis‐polyneuropathy complex in young related Pyrenean mountain dogs
Authors: Gabriel A. , Poncelet L. , Van Ham L. , Clercx C. , Braund K. G. , Bhatti S. , Detilleux J. , Peeters D. 
Published: March 2006

Objectives:To characterise clinical, electrophysiological and histopathological findings. To analyse pedigree information in six young related Pyrenean mountain dogs with laryngeal paralysis‐polyneuropathy complex (LP‐PNC).Methods:A retrospective study of clinical records and pedigrees of six young related Pyrenean mountain dogs with LP‐PNC was carried out.Results:All dogs were presented with laryngeal paralysis and concurrent megaoesophagus. Electrodiagnostic testing was performed in three dogs and showed electrophysiological abnormalities in the distal appendicular muscles. Histopathological findings of peripheral nerve samples were dominated by distal axonal degeneration. Clinical, electrophysiological and histopathological findings were supportive of a diagnosis of degenerative, sensorimotor LP‐PNC, similar to that reported in young dalmatians and rottweilers. All dogs died or were euthanased by two years of age. An autosomal recessive mode of inheritance was suspected based on pedigree analysis.ClinicalSignificance:Congenital LP‐PNC should be suspected in any young dog presenting with laryngeal dysfunction and other concurrent neurological abnormalities. The prognosis is usually poor.
Results of surgical correction of abnormalities associated with brachycephalic airway obstruction syndrome in dogs in Australia
Authors: Torrez C. V. , Hunt* G. B. 
Published: March 2006

Objectives: To describe clinical features of brachycephalic airway obstructive disease in dogs, the incidence of laryngeal collapse in dogs presenting for surgery and the outcome after surgery in dogs with laryngeal collapse. Methods: Basic clinical details were reviewed retrospectively in 73 dogs. Presence of laryngeal collapse and short‐term outcomes after surgery were determined for 64 dogs with complete medical records. Long‐term outcomes were reviewed for 46 dogs by telephone survey between 19 and 77 months following surgery. Results: Stenotic nares were present in 31 dogs (42·5 per cent), elongated soft palate in 63 (86·3 per cent) and everted laryngeal saccules in 43 (58·9 per cent). The most common breeds were the pug (19 dogs, 26 per cent), Cavalier King Charles spaniel (15 dogs, 20·5 per cent), British bulldog (14 dogs, 19·2 per cent) and Staffordshire bull terrier (4 dogs, 5·5 per cent). Laryngeal collapse was present in 34 of 64 (53 per cent) dogs. No dogs died perioperatively and only one dog was euthanased as a result of its respiratory disease three years after surgery. Telephone interviews indicated that 26 dogs (56·5 per cent) were much improved after surgery, 15 (32·6 per cent) had some improvement and 5 (10·9 per cent) showed no improvement. Signs that persisted after surgery were snoring during sleep (34 dogs, 73·9 per cent), stertor/stridor while conscious (23 dogs, 50 per cent), excessive panting (13 dogs, 28·3 per cent) and dyspnoea (10 dogs, 21·7 per cent). Long‐term outcome was considered good, even in dogs with laryngeal collapse. Clinical Significance: Laryngeal collapse is relatively common in dogs presented for surgical correction of brachycephalic airway obstructive disease. Dogs with severe laryngeal collapse often respond well to surgery. Clinical signs rarely resolve completely following surgery.
Muscular damage and intravascular haemolysis during an 18 hour subterranean exploration in a cave of 700 m depth
Authors: Stenner E , Gianoli E , Biasioli B , Piccinini C , Delbello G , Bussani A 
Published: February 2006

Objective:To verify presence and severity of muscular and/or intravascular damage during a subterranean exploration of long duration.Methods:We measured serum levels of creatine kinase (CK) and lactate dehydrogenase (LDH) as markers of muscular damage. We also measured haptoglobin as a marker of intravascular haemolysis, and platelets and leucocytes as markers of inflammation.Results:We found in all the participants an increase in CK, LDH, and platelets and leucocytes (mainly due to neutrophilia and monocytosis), and a decrease in the level of haptoglobin and circulating lymphocytes.Conclusions:The observed data suggest that continuous effort during long alpine subterranean explorations, environmental conditions, sleep deprivation, multiple impacts on rocks, and compression caused by bindings of the caving harness cause muscle damage, intravascular haemolysis, inflammation response, and immunological changes.
Prospective study of change in patellar tendon abnormality on imaging and pain over a volleyball season
Authors: Malliaras P , Cook J , Ptasznik R , Thomas S 
Published: February 2006

Objective:Patellar tendon injury, defined by tendon abnormality (TA) on imaging and by pain, is common among volleyball players, but little is known about change in this injury over a volleyball season. Increased activity in the season compared with the off season may result in the development of TA and/or pain. This study investigated the behaviour of TA and pain over a competitive volleyball season.Methods:Tendon abnormality and pain were measured in 101 volleyball players at the beginning and end of a season. Pain was measured with the single leg decline squat test, which loads the patellar tendon, and TA was detected with ultrasound imaging. Hours of weekly activity were measured and compared during the season and the off season. The proportion of tendons that underwent development and resolution in TA and/or pain over the season was investigated.Results:Hours of weekly activity was greater during the season than in the off season. Most of the tendons investigated (66.3%) did not undergo a change in TA or pain over the season. Tendon abnormality and/or pain developed in 16.6% of tendons and resolved in 11.2%.Conclusions:The tendons of volleyball players respond variably to the increased load over the season. Change in TA and pain does not appear to be entirely dependent upon load.
FUZZY SET BASED PROTOCOLS FOR PROCESS QUALITY CONTROL
Authors: DELGADO M. , OLAVARRIETA P. , VERGARA P. 
Published: March 2006

Industrial process quality control has as yet been carried out using Shewhart's classic charts and control charts with probabilistic limits, using sampling statistics for average and deviation [Formula: see text] and [Formula: see text], respectively, or Cp and Cpk, derived from them, in order to determine whether the process is precise or imprecise. Although these statistics has been formulated using crisp mathematics, their use returns statements about "quality control" which are full of vagueness (for example, the aforementioned idea of precise or imprecise processes). For this reason, it seems both natural and interesting to introduce tools from Fuzzy Sets Theory for the formulation of quality control models. Fuzzy Sets shall be used to study process quality capability and to generate a bilateral simultaneous control for the central tendency and a unilateral one for variability. We shall define linguistic rules in order to perform this control and membership functions for the sample control mean and deviation, [Formula: see text] and ŝ.
A MULTI CULTURE PERCEPTION OF THE ENTREPRENEURIAL LIFESTYLE
Authors: BENJAMIN MARTZ W. M. , BISCACCIANTI ALESSANDRO , NEIL THOMAS C. , WILLIAMS ROBERT J. 
Published: March 2006

Business schools around the world offer courses and even complete degrees emphasizing entrepreneurship. However, the perception of an entrepreneur differs across cultures. This paper presents results from a set of 900 questionnaires collected over two years in three countries: United States; United Kingdom and France. The analysis found support for the basic conjecture that the perception of entrepreneurship differs between countries; the US students perceived the entrepreneurship lifestyle as a better lifestyle than did students from the France or the UK. Historically, the area of entrepreneurship is suggested as a key factor for a successful business environment. Business schools around the world offer courses and even complete degrees emphasizing entrepreneurship. However, the perception of an entrepreneur differs across cultures. The entrepreneurial lifestyle is perceived, rewarded, acknowledged, etc. differently across cultures based upon cultural norms. This paper presents results from a set of data collected over two years in three countries: United States; United Kingdom and France. The analysis of over 900 questionnaires found support for the basic conjecture that the perception of entrepreneurship differs between countries and in the direction predicted by the TEA report; the US students perceived the entrepreneurship lifestyle better than did students from the France or the UK. The final section of the paper is highlights the cross-cultural differences found and offers some ideas on why they occur.
Fibulins 3 and 5 Antagonize Tumor Angiogenesis In vivo
Authors: Albig Allan R. , Neil Jason R. , Schiemann William P. 
Published: March 2006

Abstract
Lethal tumor growth and progression cannot occur without angiogenesis, which facilitates cancer cell proliferation, survival, and dissemination. Fibulins (FBLN) 5 and 3 are widely expressed extracellular matrix proteins that regulate cell proliferation in a context-specific manner. Reduced FBLN-5 expression has been associated with cancer formation and progression in humans, whereas its constitutive expression antagonizes endothelial cell angiogenic sprouting in vitro. Thus, FBLN-5 may suppress tumorigenesis by preventing tumor angiogenesis. FBLN-3 is homologous to FBLN-5 and expressed in endothelial cells, yet its role in tumorigenesis and angiogenesis is unknown. We find FBLN-3 expression to be altered in some human tumors and that its constitutive expression in endothelial cells inhibited their proliferation, invasion, and angiogenic sprouting, as well as their response to vascular endothelial growth factor as measured by p38 mitogen-activated protein kinase activation. In endothelial cells, both FBLNs (a) reduced angiogenic sprouting stimulated by basic fibroblast growth factor (bFGF); (b) inhibited matrix metalloproteinase expression and activity; and (c) stimulated tissue inhibitor of metalloproteinase expression. More importantly, both FBLNs prevented angiogenesis and vessel infiltration into bFGF-supplemented Matrigel plugs implanted in genetically normal mice, as well as decreased the growth and blood vessel density in tumors produced by MCA102 fibrosarcoma cells implanted s.c. into syngeneic mice. Our findings establish FBLN-3 and FBLN-5 as novel angiostatic agents capable of reducing tumor angiogenesis and, consequently, tumor growth in vivo and suggest that these angiostatic activities may one day be exploited to combat tumor angiogenesis and metastasis in cancer patients. (Cancer Res 2006; 66(5): 2621-9)
Antiangiogenic Therapy Decreases Integrin Expression in Normalized Tumor Blood Vessels
Authors: Yao Virginia J. , Ozawa Michael G. , Varner Amanda S. , Kasman Ian M. , Chanthery Yvan H. , Pasqualini Renata , Arap Wadih , McDonald Donald M. 
Published: March 2006

Abstract
Tumor blood vessels normalized by antiangiogenic therapy may provide improved delivery of chemotherapeutic agents during a window of time but it is unknown how protein expression in tumor vascular endothelial cells changes. We evaluated the distribution of RGD-4C phage, which binds αvβ3, αvβ5, and α5β1 integrins on tumor blood vessels before and after antiangiogenic therapy. Unlike the control phage, fd-tet, RGD-4C phage homed to vascular endothelial cells in spontaneous tumors in RIP-Tag2 transgenic mice in a dose-dependent fashion. The distribution of phage was similar to αvβ3 and α5β1 integrin expression. Blood vessels that survived treatment with AG-013736, a small molecule inhibitor of vascular endothelial growth factor and platelet-derived growth factor receptors, had only 4% as much binding of RGD-4C phage compared with vessels in untreated tumors. Cellular distribution of RGD-4C phage in surviving tumor vessels matched the α5β1 integrin expression. The reduction in integrin expression on tumor vessels after antiangiogenic therapy raises the possibility that integrin-targeted delivery of diagnostics or therapeutics may be compromised. Efficacious delivery of drugs may benefit from identification by in vivo phage display of targeting peptides that bind to tumor blood vessels normalized by antiangiogenic agents. (Cancer Res 2006; 66(5): 2639-49)
Cyclin D1 Is Transcriptionally Regulated by and Required for Transformation by Activated Signal Transducer and Activator of Transcription 3
Authors: Leslie Kenneth , Lang Cynthia , Devgan Geeta , Azare Janeen , Berishaj Marjan , Gerald William , Kim Young Bae , Paz Keren , Darnell James E. , Albanese Christopher , Sakamaki Toshiyuki , Pestell Richard , Bromberg Jacqueline 
Published: March 2006

Abstract
Signal transducers and activators of transcription 3 (STAT3) is a transcription factor that is aberrantly activated in many cancer cells. Constitutively activated STAT3 is oncogenic, presumably as a consequence of the genes that it differentially regulates. Activated STAT3 correlated with elevated cyclin D1 protein in primary breast tumors and breast cancer–derived cell lines. Cyclin D1 mRNA levels were increased in primary rat-, mouse-, and human-derived cell lines expressing either the oncogenic variant of STAT3 (STAT3-C) or vSrc, which constitutively phosphorylates STAT3. Mutagenesis of STAT3 binding sites within the cyclin D1 promoter and chromatin immunoprecipitation studies showed an association between STAT3 and the transcriptional regulation of the human cyclin D1 gene. Introduction of STAT3-C and vSrc into immortalized cyclin D1−/− and cyclin D1−/+ fibroblasts led to anchorage-independent growth of only cyclin D1−/+ cells. Furthermore, knockdown of cyclin D1 in breast carcinoma cells led to a reduction in anchorage-independent growth. Phosphorylation of the retinoblastoma (Rb) protein [a target of the cyclin D1/cyclin-dependent kinase 4/6 (cdk4/6) holoenzyme] was delayed in the cyclin D1−/− cells relative to cyclin D1−/+ cells. The E7 oncogene, whose activity includes degradation of Rb and dissociation of Rb from E2F, did not confer anchorage-independent growth to the cyclin D1−/− cells but, in conjunction with vSrc, resulted in robust growth in soft agar. These results suggest both a cdk-dependent and cdk-independent role for cyclin D1 in modulating transformation by different oncogenes. (Cancer Res 2006; 66(5): 2544-52)
A Novel Mechanism for Integrin-Mediated Ras Activation in Breast Carcinoma Cells: The α6β4 Integrin Regulates ErbB2 Translation and Transactivates Epidermal Growth Factor Receptor/ErbB2 Signaling
Authors: Yoon Sang-Oh , Shin Sejeong , Lipscomb Elizabeth A. 
Published: March 2006

Abstract
ErbB2 (HER2, Neu) and Ras play key roles in tumor invasion and metastasis. We identified a novel mechanism by which integrin α6β4 regulates ErbB2 expression, Ras activation, and the invasion of breast carcinoma cells. Here we show that integrin α6β4 regulates Ras activity especially in serum-depleted condition. Down-regulation of β4 integrin by β4 short hairpin RNA (shRNA) decreased Ras activity and carcinoma invasion whereas reexpression of this integrin restored Ras activity. ErbB2, a binding partner of epidermal growth factor receptor (EGFR), and EGFR modulated Ras activity, and integrin α6β4 regulated phospho-EGFR level without affecting EGFR expression. We also found that integrin α6β4 is involved in ErbB2 expression. Depletion of β4 by shRNA reduced ErbB2 protein level without affecting ErbB2 mRNA level and reexpression of β4 increased ErbB2 protein level. Reduction of eukaryotic initiation factor 4E, a rate-limiting factor for cap-dependent translation, decreased ErbB2 protein level, and β4 shRNA cells exhibited a shift in ErbB2 mRNA to light polysomes compared with control cells. These results show that integrin α6β4 regulates ErbB2 through translational control. In summary, we propose a novel mechanism for ErbB2 up-regulation and Ras activation in serum-depleted breast cancer cells; integrin α6β4 regulates the expression of ErbB2 and the subsequent phosphorylation of EGFR and activation of Ras. These findings provide a mechanism that substantiates the reported role of α6β4 in carcinoma invasion. (Cancer Res 2006; 66(5): 2732-9)
Role of the Tumor Suppressor RASSF1A in Mst1-Mediated Apoptosis
Authors: Oh Hyun Jung , Lee Kyung-Kwon , Song Su Jung , Jin Mi Sun , Song Min Sup , Lee Joo Hyun , Im Chang Rak , Lee Jie-Oh , Yonehara Shin , Lim Dae-Sik 
Published: March 2006

AbstractMammalian sterile 20–like kinase 1 (Mst1) is activated by both caspase-mediated cleavage and phosphorylation in response to apoptotic stimuli, including Fas ligation. Here, we examined the possible role of the tumor suppressor RASSF1A in Mst1 activation and Mst1-mediated apoptosis induced by death receptor signaling. Immunoprecipitation and immunofluorescence analyses revealed that Mst1 was associated with RASSF1A in cultured mammalian cells, with both proteins colocalizing to microtubules throughout the cell cycle. Whereas purified recombinant RASSF1A inhibited the kinase activity of purified recombinant Mst1 in vitro, overexpression of RASSF1A increased the kinase activity of Mst1 in intact cells, suggesting that regulation of Mst1 by RASSF1A in vivo involves more than the simple association of the two proteins. Both the activation of Mst1 and the incidence of apoptosis induced by Fas ligation were markedly reduced in cells depleted of RASSF1A by RNA interference and were increased by restoration of RASSF1A expression in RASSF1A-deficient cells. Moreover, the stimulatory effect of RASSF1A overexpression on Fas-induced apoptosis was inhibited by depletion of Mst1. These findings indicate that RASSF1A facilitates Mst1 activation and thereby promotes apoptosis induced by death receptor signaling. (Cancer Res 2006; 66(5): 2562-9)
Renal Cyst Development in Mice with Conditional Inactivation of the von Hippel-Lindau Tumor Suppressor
Authors: Rankin Erinn B. , Tomaszewski John E. , Haase Volker H. 
Published: March 2006

AbstractInactivation of the von Hippel-Lindau tumor suppressor, pVHL, is associated with both hereditary and sporadic renal cysts and renal cell carcinoma, which are commonly thought to arise from the renal proximal tubule. pVHL regulates the protein stability of hypoxia-inducible factor (HIF)-α subunits and loss of pVHL function leads to HIF stabilization. The role of HIF in the development of VHL-associated renal lesions remains to be determined. To investigate the functional consequences of pVHL inactivation and the role of HIF signaling in renal epithelial cells, we used the phosphoenolpyruvate carboxykinase (PEPCK) promoter to generate transgenic mice in which Cre-recombinase is expressed in the renal proximal tubule and in hepatocytes. We found that conditional inactivation of VHL in PEPCK-Cre mutants resulted in renal cyst development that was associated with increased erythropoietin levels and polycythemia. Increased expression of the HIF target gene erythropoietin was limited to the liver, whereas expression of carbonic anhydrase 9 and multidrug resistance gene 1 was up-regulated in the renal cortex of mutant mice. Inactivation of the HIF-α binding partner, arylhydrocarbon receptor nuclear translocator (Arnt), but not Hif-1α, suppressed the development of renal cysts. Here, we present the first mouse model of VHL-associated renal disease that will provide a basis for further genetic studies to define the molecular events that are required for the progression of VHL-associated renal cysts to clear cell renal cell carcinoma. (Cancer Res 2006; 66(5): 2576-83)
XRCC1 Genotype and Breast Cancer: Functional Studies and Epidemiologic Data Show Interactions between XRCC1 Codon 280 His and Smoking
Authors: Pachkowski Brian F. , Winkel Scott , Kubota Yoshiko , Swenberg James A. , Millikan Robert C. , Nakamura Jun 
Published: March 2006

Abstract
Tobacco smoke produces oxidative and alkylative DNA damage that necessitates repair by base excision repair coordinated by X-ray cross-complementing gene 1 (XRCC1). We investigated whether polymorphisms in XRCC1 alter DNA repair capacity and modify breast cancer risk associated with smoking. To show the functionality of the 280His variant, we evaluated single-strand break (SSB) repair capacity of isogenic Chinese hamster ovary cells expressing human forms of XRCC1 after exposure to hydrogen peroxide (H2O2), methyl methanesulfonate (MMS), or camptothecin by monitoring NAD(P)H. We used data from the Carolina Breast Cancer Study (CBCS), a population-based, case-control study that included 2,077 cases (786 African Americans and 1,281 Whites) and 1,818 controls (681 African Americans and 1,137 Whites), to examine associations among XRCC1 codon 194, 280, and 399 genotypes, breast cancer, and smoking. Odds ratios and 95% confidence intervals (95% CI) were calculated by unconditional logistic regression. Only cells expressing the 280His protein accumulated SSB, indicated by NAD(P)H depletion, from both H2O2 and MMS exposures. In the CBCS, positive associations were observed between breast cancer and smoking dose for participants with XRCC1 codon 194 Arg/Arg (Ptrend = 0.046), 399 Arg/Arg (Ptrend = 0.012), and 280 His/His or His/Arg (Ptrend = 0.047) genotypes. The 280His allele was in strong linkage disequilibrium with 194Arg (Lewontin's D′ = 1.0) and 399Arg (D′ = 1.0). These data suggest that less common, functional polymorphisms may lie within common haplotypes and drive gene-environment interactions. (Cancer Res 2006; 66(5): 2860-8)