bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of α‐1‐acid glycoprotein isoforms from healthy and cancer patients by capillary IEF
Authors: Lacunza Izaskun , Kremmer Tibor , Díez‐Masa José Carlos , Sanz Jesús , de Frutos Mercedes 
Published: November 2007

Abstractα‐1‐Acid glycoprotein (AGP) is a glycoprotein that presents different forms in the same individual, depending on the amino acid sequence and/or on the carbohydrate distribution of each form. Changes in these two types of heterogeneities are related to pathophysiological states. The aim of this work is to study the possibility of comparing AGP samples in terms of their CIEF profiles, what would facilitate in a future to perform studies about the role of AGP as a disease marker. In the present study, the CIEF profiles of AGP samples purified from sera of healthy donors and of ovary cancer and lymphoma patients are qualitatively and quantitatively compared. To make possible the comparison of those electrophoretical profiles, reliable assignment of AGP peaks is necessary. A computer program developed in our laboratory is used to select the migration parameters that make possible an accurate assignment of AGP peaks. Percentages of correct assignment of AGP peaks using the migration time of each peak relative to the migration time of an internal standard close to 95% are achieved. After peak assignment, a different distribution of the area percentage of AGP forms is observed when comparing samples from diseased and healthy individuals, the most acidic AGP forms being present in a higher proportion in the samples from cancer patients. Although the number of samples studied is too low to get any clinical significance from these results, this work provides a way to study the role of AGP as a biomarker.
Quantitative proteome analysis of cisplatin‐induced apoptotic Jurkat T cells by stable isotope labeling with amino acids in cell culture, SDS‐PAGE, and LC‐MALDI‐TOF/TOF MS
Authors: Schmidt Frank , Hustoft Hanne K. , Strozynski Margarita , Dimmler Christiane , Rudel Thomas , Thiede Bernd 
Published: November 2007

AbstractQuantitative proteome analysis of cisplatin‐induced apoptosis in total Jurkat T cell lysates was performed in order to identify modified proteins. Proteins were labeled in cell culture with stable isotopes of arginines, and fractionated by SDS‐PAGE. Subsequently, tryptic peptides were analyzed by nano‐LC coupled offline to MALDI‐TOF/TOF‐MS as an alternative to commonly used online LC‐ESI‐MS. As a result, 26 proteins were found with a relative abundance higher than 1.5, thereof 19 already known and seven unknown to be involved in apoptosis (adenine phosphoribosyltransferase, microsomal signal peptidase 25 kDa subunit, phosphomevalonate kinase, probable rRNA processing protein EBP2, RNA‐binding protein 4, transmembrane protein 33, and tetratricopeptide repeat domain 9C). Immunoblotting of core‐binding factor beta and elongation factor 2 revealed similar quantitative changes as detected by the SILAC‐based proteomics approach. Strikingly, 8 of 26 identified apoptosis‐modified proteins contained at least one RNA‐binding motif. Three caspase cleavage sites of the 54 kDa nuclear RNA‐binding protein (p54nrb) were mapped at DQLD231↓D, DQVD286↓R, and MMPD422↓G by applying caspase‐3 to the in vitro translated protein and mutation analysis. The determined caspase cleavage sites were located C‐terminal to the two RNA‐binding motifs and one (DQLD231↓D) within the NOPS domain of p54nrb. Concisely, quantitative protein data generated by offline LC‐MALDI‐MS were shown to be particularly accurate. Furthermore, only regulated peptides were selected in a result‐dependent manner for MS/MS analyses and revealed novel apoptosis‐modified proteins.
The EC Eco‐management and audit regulation: Experiences from the pilot exercise
Authors: Hemming Christine 
Published: November 2007

AbstractThe European Community recently agreed a Regulation establishing a voluntary scheme to give recognition to companies which have established environmental policies, programmes, management systems and auditing systems in accordance with its requirements. While the Regulation was in the agreement process, the European Commission sponsored a pilot exercise of some of its requirements. This pilot exercise was managed by PA Consulting Group and has recently been completed. It involved 17 industrial sites around the European Community, ranging in size from tens to thousands of employees and covering 9 broad industrial sectors. This article provides an overview of the pilot exercise and summarises some of its main findings. Copyright © 1993 John Wiley & Sons, Ltd and ERP Environment.
Piloting the EC eco‐management and audit scheme: The experience of BSB recycling GmbH, Germany
Authors: Röpenack Adolf von 
Published: November 2007

AbstractOne of the sites which participated in the pilot exercise of environmental auditing under the EC's new Eco‐management and audit scheme was BSB Recycling GmbH at Braubach in Germany. This paper describes the experiences of the site with the pilot exercise with particular emphasis on the benefits which participation in the scheme has brought to the site and its parent companies. BSB and its parent companies are supporters of the concept of self‐regulation which forms the basis for this EC Regulation and an increasing number of legislative instruments for environmental protection. Copyright © 1993 John Wiley & Sons, Ltd and ERP Environment.
Land audits: Law and practice
Authors: Sykes Stephen 
Published: November 2007

AbstractEnvironmental professionals tend to look for the worst, and exhibit disappointment when they do not find it. That applies to land experts: they search for contamination rather than the more positive aim of confirming that land is clean. This paper addresses ‘land audits’ (rather than ‘contaminated land audits’: it makes no assumptions about the quality of the land being assessed. Audits can be commissioned for positive reasons and do not simply confirm the worst. This paper presents a practical approach to auditing land, and considers the critical role which lawyers have to play in that process, and what might happen if environmental consultants were to have it all their own way. Copyright © 1993 John Wiley & Sons, Ltd and ERP Environment.
Working with industry to improve the environment: Coventry city council's greening industry strategy
Authors: Slater Marc 
Published: November 2007

AbstractIndustry has a key role in the improvement of our environment, the move towards sustainable development. Coventry City Council has been working in partnership with companies to improve their environmental performance, the local environment. This article outlines the development of Coventry's Greening Industry Strategy, the initiatives that have developed as a result. Copyright © 1994 John Wiley & Sons, Ltd. and ERP Environment
Environmental management and auditing: Can I.T. help?
Authors: Stubbs Mark 
Published: November 2007

AbstractThis paper offers an investigation of the role of information technology (IT) in environmental management, adopting Shrivastava's (1992) ‘reform environmentalism’ perspective to consider the relationship between business and the socio‐ecological environment. Written in the context of European Community business but focusing in particular upon the experience of organisations in the United Kingdom, it outlines some of the challenges faced when attempting to embrace the concept of sustainable development in the day‐to‐day management of business activities. The paper puts forward the view that the role of Environmental Management is primarily one of risk management and learning where the quality of environmental information is paramount. Management of the data necessary to deliver this information is seen as an area in which flexible IT systems with high communication capability can make a significant contribution. Investigation of the role which IT might play is developed further through a series of metaphors supported by examples; IT as a policeman, IT as a researcher, IT as a prompt, IT as a fortune‐teller, IT as an artist and IT as a team and the paper argues the importance of considering organisational context in any appreciation of the role of IT. Copyright © 1994 John Wiley & Sons, Ltd. and ERP Environment
I.T. and environmental management in british gas and lancashire county council
Authors: Nixon Keith , Stubbs Mark , Whitaker Mary 
Published: November 2007

AbstractIncreasingly organisations adopting eco‐management and auditing initiatives are looking to information technology (IT) to help them cope with the volume of data which must be collected and analysed if environmentally responsible decision‐making is to take place. This paper reviews the approaches adopted by two organisations: British Gas plc and Lancashire County Council, both of which have recently developed computer‐based information systems to help them implement their respective environmental policies. This article summarises case studies of the two organisations and their use of IT in environmental management1. Copyright © 1994 John Wiley & Sons, Ltd. and ERP Environment
Environmental information and corporate liability
Authors: Jones David 
Published: November 2007

AbstractIncreased public access to environmental information is a subject of growing significance, which impacts upon a wide variety of organisations. Environmental reporting and disclosure of environmental information is a growth area among many commercial concerns, whose motivation, and approach to ‘going public’ often vary considerably. This paper examines the implications of these trends and their effect upon corporate liability. Copyright © 1994 John Wiley & Sons, Ltd. and ERP Environment
The EU eco‐management and audit scheme as a vehicle to promote cleaner production
Authors: Hillary Ruth 
Published: November 2007

AbstractThe role of the eco‐management and audit scheme (EMAS) as a means to promote cleaner production processes is explored. The development of the European Union's use of market‐based policy instruments is traced, detailing the increasing acceptance of the principle of self‐regulation. The potential institutional conflicts and internal barriers to acceptance of self‐regulation are also explored. EMAS is reviewed to show its potential impact in promoting cleaner operations in organizations. Examples are highlighted to illustrate the difficulties companies experience when they move from a regulated to a self‐regulated framework. Copyright © 1995 John Wiley & Sons, Ltd. and ERP Environment
Environmental management systems and forest certification: A discussion of merits
Authors: Groves Michael A. , Lambert Anthony J. 
Published: November 2007

AbstractForest certification is the response to a perceived need for consumers to assure themselves that wood products are from well‐managed or sustainable sources. This paper takes a look at the framework for forest certification that is evolving and compares it with the emerging schemes for environmental management systems. A view is then put as to the preferred way forward for any organization in the wood value chain‐from forest managers through importers to wood product manufacturers and retailers‐seeking independent verification of good management practices. Copyright © 1995 John Wiley & Sons, Ltd. and ERP Environment
Internal environmental audits: The role of the internal audit department
Authors: Wade Keith 
Published: November 2007

AbstractStaff from an organisation's internal audit department have a part to play in environmental audits. The image of internal auditors as financial inspectors is outdated and they can make a potential contribution, in conjunction with others, to an environmental audit through a professional, objective evaluation of the strength of controls within environmental management systems at all levels within the organization. Copyright © 1995 John Wiley & Sons, Ltd. and ERP Environment
Quality auditors and environmental auditors: Can these two roles be combined?
Authors: Sammalisto Kaisu 
Published: November 2007

AbstractThe possibilities of integrating the functions of quality and environmental auditors are explored. The various standards for quality and environmental management systems are presented and the different requirements they place on an auditor summarized. The effects of the integration of the auditor function are considered. It is noted that an integration of these management systems and an integration of the auditor function would be most feasible in small‐and medium‐sized companies with limited sizes and resources. The integration could cause some conflicts, but these could be overcome by a strong commitment from the auditor and strong support from company management. Copyright © 1995 John Wiley & Sons, Ltd. and ERP Environment
Profiting from improved environmental performance
Authors: Mudie Peter 
Published: November 2007

AbstractIf there is an issue about which UK businesses can be absolutely certain over the next few years it is that the pressure on companies to comply with legislation and to limit their impact on the environment will grow. International concern, increasing public awareness and tougher legislation will keep the issue high on the business agenda. Today, the environment is no longer the preserve of just a few enlightened industrialists. The roll‐call of companies committed to change and to better management of resources is extensive. Those who fail to understand the issues or to read the signals face increasing isolation in a business environment where improving corporate environmental performance is not just about threats and the costs of compliance. Increasingly, the focus is on better management, controlling costs and making the best use of the available resources. Copyright © 1995 John Wiley & Sons, Ltd. and ERP Environment
The eco‐management and audit scheme: Experience and benefits
Authors: Saint Bris Henry , Kok Edwin E.H.J. 
Published: November 2007

AbstractOne year ago, Ernst & Young's Environment Group performed a survey in four countries on management's understanding of and attitude towards the environment. In March 1993 the European Union's voluntary eco‐management and audit Regulation was adopted by the Council of Ministers (Regulation EC 1836/93). This regulation, which provides a framework for environmental verification, much like that performed in the context of ISO quality certifications, became fully operational in March 1995. At the time of writing, countries are putting into place the mechanisms and organizations that will actually carry out the task of verification. This paper examines a French pilot project that has begun to define and formalize the verification process. The pilot project is a means of testing that the necessary legal framework is in place to support the environmental management scheme, and to address challenges in implementing the eco‐management and audit activities. The expected benefits of participation in the verification process are considered. Copyright © 1995 John Wiley & Sons, Ltd. and ERP Environment
A real‐time assimilation algorithm applied to near‐surface ocean wind fields
Authors: Malmberg Anders , Holst Jan , Holst Ulla 
Published: November 2007

AbstractMarine operations depend on the ability to forecast suddenly appearing storms, and failures often cause great damage. As part of a sea‐state alarm study, meteorological forecasts overlaid with satellite observations sent to ships have been found to be a useful tool. In this paper we present a real‐time assimilation algorithm that extends this tool using statistical methods. The algorithm is applied to near‐surface ocean wind fields. A Kalman filter based on a spatio‐temporal state–space model provides a basis for emulation of the atmospheric model. The main contribution of this paper is the algorithm that makes it possible to use the information in the satellite observations over the full spatial domain of interest at a real‐time basis. Copyright © 2007 John Wiley & Sons, Ltd.
Linear and nonlinear alignment of time series with applications to varve chronologies
Authors: Auestad Bjørn H. , Shumway Robert H. , Tjøstheim Dag , Verosub Kenneth L. 
Published: November 2007

AbstractThe problem of aligning time series arises naturally in a number of fields, but our investigation is motivated by the problem of extracting a paleoclimatic signal from glacial varve chronologies. Glacial varves are laminated sediments that record annual depositional cycles in certain lakes that are fed by glaciers. Varve thickness is determined by temperature and to a lesser extent by precipitation so that an accurate reconstruction of varve chronologies can be regarded as providing a potential long term proxy for paleoclimate. An important aspect of the varve problem is to align series from different locations. What makes the alignment problem particularly interesting is that in either series, one or more varves may be missing or a single varve might have been mistaken for a pair of varves.Traditionally, alignment problems have been treated using linear methods and concepts such as coherency and cross correlation. Since one of the pairs of varve series we look at is not well described by a linear model, in this paper we also employ nonlinear criteria that are derived from recent work on nonlinear identification and dependence modeling. More precisely, we use nonlinear least squares and measures of dependence such as the Kullback—Leibler measure and the Hellinger distance. Both local and global alignment are considered, and in particular we treat the situation where one or more observations may be missing from either series. Properties of the criteria are given and illustrated by simulation. We display examples where linear methods fail, but nonlinear criteria work. For the real data set of varves at our disposal, it will be seen that the nonlinear criteria perform as well as (or better than) the linear ones for the linearly related series, and that only the nonlinear criteria work for the two series that are not linearly related. Copyright © 2007 John Wiley & Sons, Ltd.
LBWS: a load‐balanced distributed scheduler for WASPNET optical packet switches
Authors: López‐Bravo Cristina , González‐Castaño Francisco J. , Rodelgo‐Lacruz Miguel , Pavón‐Mariño Pablo , García‐Haro Joan 
Published: November 2007

AbstractIn this paper we propose a novel scheduling approach for optical packet switching (OPS) WASPNET nodes, LBWS. Unlike the original WASPNET description, our scheduler is fully distributed and its computational cost is independent from switch size. This allows shorter packets, improving network performance. Based on a deterministic evolution of the switch configuration, our scheduling algorithm predicts packet delays at packet ingress to guarantee switch stability, and assigns fibre delay lines (FDLs) accordingly. It is not necessary to emulate RAM memories, since we assign delay lines according to packet delay predictions. We demonstrate that LBWS outperforms WASPNET in the cases studied, for nonuniform input traffic. Copyright © 2007 John Wiley & Sons, Ltd.
Numerical investigation of the effects of sluice spillway roof profiles on the hydraulic characteristics
Authors: Bhajantri M. R. , Eldho T. I. , Deolalikar P. B. 
Published: November 2007

AbstractThere is a need for evolving hydraulically efficient roof profile of bellmouth for high head sluice spillways, as sluice roof is susceptible to cavitation damage. In this paper, formulation and development of a numerical model for simulating the spillway flow and its application to a sluice spillway are presented. The main focus of the simulation study is to apply the developed model to investigate the effects of sluice roof profile geometry on the pressure distribution, the discharge coefficient and the nature of flow regime within the sluice bellmouth. From the analysis of results for eight different roof profiles by varying the entry and exit angles of elliptic bellmouth transition, some important observations have been suggested, which are of practical relevance to hydraulic design engineers. The numerical model results are compared for one profile with physical model study. The simulated results are in close agreement with the measured values. Copyright © 2007 John Wiley & Sons, Ltd.
Usability of explicit filtering in large eddy simulation with a low‐order numerical scheme and different subgrid‐scale models
Authors: Brandt Tellervo T. 
Published: November 2007

AbstractBased on a priori tests, in large eddy simulation (LES) of turbulent fluid flow, the numerical error related to low‐order finite‐difference‐type methods can be large in comparison with the effect of subgrid‐scale (SGS) model. Explicit filtering has been suggested to reduce the error, and it has shown promising results in a priori studies and in some simulations with fourth‐order method. In this paper, the effect of explicit filtering on the total simulation error is studied together with a second‐order scheme, where the numerical error should be even larger. The fully developed turbulent channel flow between two parallel walls is used as a test case. Rather simple SGS models are applied, because these models are most likely used in practical applications of LES. Explicit filtering is here applied to the non‐linear convection term of the Navier–Stokes equations, four three‐dimensional filter functions are applied, and the effect of filtering is separated from the effect of SGS modelling. It is shown that the effect of filtering is rather large and smooth filters introduce an additional error component that increases the total simulation error. Finally, filtering via subfilter‐scale modelling is applied, and it is shown that this approach performs better. However, the large‐frequency components of the resolved flow field are not as effectively damped as when the non‐linear convection term is filtered. Copyright © 2007 John Wiley & Sons, Ltd.
The important role of the phosphorus lone pair in phosphole aromaticity
Authors: Chesnut D. B. , Quin L. D. 
Published: November 2007

AbstractCalculations on phosphole systems using the G3MP2B3 model chemistry show that the phosphorus lone pair is critical to the system's aromaticity. Protonation of the lone pair results in antiaromatic molecules as measured by homomolecular homodesmotic reactions. Attempts to separate out effects of hyperconjugation on the butadiene portion of the system are unsuccessful with current practices. Because these hyperconjugation effects will tend to cancel each other in the phosphole systems, analyses using the unmodified homomolecular homodesmotic reactions are considered reasonable measures of their aromaticity. © 2007 Wiley Periodicals, Inc. Heteroatom Chem 18:754–758, 2007; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20364
A theoretical study on the mechanism of the baeyer–villiger type oxidation of 7‐phosphanorbornene 7‐Oxides
Authors: Kovács Attila , Nemcsok Dénes S. , Keglevich György 
Published: November 2007

AbstractDFT computations have been performed on selected stationary points of the reaction path (reactants, intermediates, and products) of the Baeyer–Villiger type oxidation of 7‐phosphanorbornene 7‐oxide derivatives. Our computations justified the relevance of a Criegee‐type intermediate forming in the first step, analogously to the Baeyer–Villiger oxidation of ketones. The energy profile indicated a high‐energy barrier from the side of the products, supporting the kinetic character of the mechanism. The computations revealed that the mechanism does not include a previously assumed Berry‐pseudorotation step in the Criegee‐type intermediate. On the basis of the present results, we suggest that the regioselectivity of the Baeyer–Villiger type oxidation of the 7‐phosphanorbornene 7‐oxide derivatives may be determined by steric interactions between the leaving meta‐chlorobenzoate group and substituents on the 7‐phosphanorbornene skeleton in the Criegee‐type intermediate. © 2007 Wiley Periodicals, Inc. Heteroatom Chem 18:759–766, 2007; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20366