bluuebunny/crossref_metadata_2025_split huggingface dataset:
Selective Nucleophilic Replacement of the Benzylsulfanyl Group in 2,4‐Disulfanyl‐substituted Thieno[2,3‐d]pyrimidin‐6‐carboxylic Acid Derivatives by Secondary Amines.
Authors: Briel Detlef , Drescher Simon , Dobner Bodo 
Published: November 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
An Asymmetric ent‐Kauranoid Dimer from Isodon rubescens var. lushanensis.
Authors: Han Quan‐Bin , Lu Yang , Wu Li , He Zhen‐Dan , Qiao Chun‐Feng , Xu Hong‐Xi , Zheng Qi‐Tai , Sun Han‐Dong 
Published: November 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Stripping off Water at Ambient Temperature: Direct Atom‐Efficient Acetal Formation Between Aldehydes and Diols Catalyzed by Water‐Tolerant and Recoverable Vanadyl Triflate.
Authors: Chen Chien‐Tien , Weng Shiue‐Shien , Kao Jun‐Qi , Lin Chun‐Cheng , Jan Mi‐Dan 
Published: November 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Biosynthetic Capacities of Actinomycetes. Part 34. Novel Marine Natural Products. Part 8. Gephyromycin, the First Bridged Angucyclinone, from Streptomyces griseus Strain NTK 14
Authors: Bringmann Gerhard , et al. et al. 
Published: November 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Crystal Growth, Structural Transitions, and Magnetic Properties of the Fluorite‐Related Osmates: Sm3OsO7, Eu3OsO7, and Gd3OsO7.
Authors: Gemmill William R. , Smith Mark D. , Mozharivsky Yurij A. , Miller Gordon J. , zur Loye Hans‐Conrad 
Published: November 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Compounds Ln5(Ag, Ga)19‐x (Ln: Gd, Tb) — Defective Partially Ordered Representatives of the Rb5Hg19 Structure Type.
Authors: Gumeniuk Roman V. , Akselrud Lev G. , Kuz'ma Yurij B. 
Published: November 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Highly Regio‐, Chemo‐ and Diastereoselective Synthesis of Oxa‐Bridged Spirocycles: A Novel Observation of Reverse Selectivity.
Authors: Muthusamy Sengodagounder , Krishnamurthi Janagiraman , Nethaji Munirathnam 
Published: November 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis, Characterization and Structure of a Tetrameric DABCO—Bromine Complex: A Novel Oxidizing Agent for Oxidation of Alcohols to Carbonyl Compounds.
Authors: Heravi Majid M. , Derikvand Fatemeh , Ghassemzadeh Mitra , Neumueller Bernhard 
Published: November 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Chromium‐Mediated Fluoroalkenylation Reactions of 1,1‐Dibromo‐1‐fluoroalkane and 1‐Bromo‐1‐fluoroalkene Derivatives.
Authors: Saito Akio , Nakagawa Muga , Taguchi Takeo 
Published: November 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Highly Regio‐ and Enantioselective Asymmetric Hydroformylation of Olefins Mediated by 2,5‐Disubstituted Phospholane Ligands.
Authors: Axtell Alex T. , Cobley Christopher J. , Klosin Jerzy , Whiteker Gregory T. , Zanotti‐Gerosa Antonio , Abboud Khalil A. 
Published: November 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Nucleophilic Addition to Acetylenes in Superbasic Catalytic Systems. Part 14. Vinylation of Diols in a System CsF—NaOH.
Authors: Oparina L. A. , Khil'ko M. Ya. , Chernyshova N. A. , Shaikhudinova S. I. , Parshina L. N. , Preiss Th. , Henkelmann J. , Trofimov B. A. 
Published: November 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Cyclopropyl Building Blocks for Organic Synthesis. Part 112. Titanium‐Mediated Cyclopropanation of N,N‐Dibenzylcarboxamides Towards Functionally Substituted 2‐(1′‐Aminocyclopropyl)acetic Acids.
Authors: Brackmann Farina , de Meijere Armin 
Published: November 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Organocatalysis Using Protonated 1,2‐Diamino‐1,2‐diphenylethane for Asymmetric Diels—Alder Reaction.
Authors: Kim Kyoung Hoon , Lee Seil , Lee Dae‐Woong , Ko Dong‐Hyun , Ha Deok‐Chan 
Published: November 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis of Biologically Active Substances Based on Phenoxyethanol Derivatives.
Authors: Kukovinets O. S. , Yamansarova E. T. , Kasradze V. G. , Lozhkina E. A. , Zainullin R. A. , Abdullin M. I. 
Published: November 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Rare Earth(III) Perfluorooctane Sulfonates and Perfluorooctanesulfonic Acid in Fluorous Solvents: Novel and Recyclable Catalytic Systems for Friedel—Crafts Acylation of Unactivated Benzenes.
Authors: Yi Wen‐Bin , Cai Chun 
Published: November 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
A Mild and Efficient Synthesis of 5‐Oxo‐5,6,7,8‐tetrahydro‐4H‐benzo‐[b]‐pyran Derivatives in Room Temperature Ionic Liquids.
Authors: Jiang Zhao‐Qin , Ji Shun‐Jun , Lu Jun , Yang Jin‐Ming 
Published: November 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Molecular Iodine Catalyzed One‐Pot Synthesis of 4‐Substituted‐1,4‐dihydropyridine Derivatives via Hantzsch Reaction.
Authors: Ko Shengkai , Sastry M. N. V. , Lin Chunchi , Yao Ching‐Fa 
Published: November 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
High Throughput Synthesis of Pyrazolopyrimidines via Copper‐Catalyzed Cyclization and X‐Ray Study.
Authors: Abdel‐Jalil Raid J. , Khanfar Monther , Al‐Gharabli Samer , El‐Abadelah Mustafa M. , Eichele Klaus , Anwar Muhammad Usman , Voelter Wolfgang 
Published: November 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
A Selective Synthesis of 3,6‐Dihydro‐7H‐1,2,3‐triazolo[4,5‐d]pyrimidin‐7‐ones.
Authors: Zhao Jun‐Feng , Xie Chang , Ding Ming‐Wu , He Hong‐Wu 
Published: November 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Selective Synthesis and Cycloaddition Reactions of New Azomethine Imines Containing a 1,2,4‐Triazine Ring.
Authors: Grof Csilla , Hegedus Gabor , Riedl Zsuzsanna , Hajos Gyoergy , Egyed Orsolya , Csampai Antal , Kudar Veronika , Stanovnik Branko 
Published: November 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Second Generation N‐Heterocyclic Carbene—Pt(0) Complexes as Efficient Catalysts for the Hydrosilylation of Alkenes.
Authors: Buisine Olivier , Berthon‐Gelloz Guillaume , Briere Jean‐Francois , Sterin Sebastien , Mignani Gerard , Branlard Paul , Tinant Bernard , Declercq Jean‐Paul , Marko Istvan E. 
Published: November 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Convenient Palladium‐Catalyzed Arsination: Direct Synthesis of Functionalized Aryl Arsines, Optically Active As,N Ligands, and Their Metal Complexes.
Authors: Kwong Fuk Yee , Lai Chi Wai , Yu Michael , Tan Duan‐Ming , Lam Fuk Loi , Chan Albert S. C. , Chan Kin Shing 
Published: November 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Novel Strategies for the Preparation of Aminocarbasugar Analogues: Syntheses of N‐Substituted Aminocyclitols from D‐Mannose.
Authors: Gomez Ana M. , Moreno Eduardo , Uriel Clara , Jarosz Slawomir , Valverde Serafin , Lopez J. Cristobal 
Published: November 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
New Sesquicillins, Insecticidal Antibiotics Produced by Albophoma sp. FKI‐1778
Authors: Uchida Ryuji , Imasato Rie , Yamaguchi Yuichi , Masuma Rokuro , Shiomi Kazuro , Tomoda Hiroshi , Omura Satoshi 
Published: November 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Fluorinated Pyridine Derivatives. Part 1. The Synthesis of Some Mono‐ and Bis‐quaternary Pyridine Salts of Potential Use in the Treatment of Nerve Agent Poisoning.
Authors: Timperley Christopher M. , Bird Mike , Heard Suzannah C. , Notman Stuart , Read Robert W. , Tattersall John E. H. , Turner Simon R. 
Published: November 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Structure—Property Relationship of Permutite‐Like Amorphous Silicates, Nax+2yM3+xSi1‐xO2+y (M3+: Al, Mn, Fe, Y), for Ion‐Exchange Reactions.
Authors: Pless Jason D. , Maxwell Robert S. , Philips Mark L. F. , Helean Katheryn B. , Axness Marlene Y. , Nenoff Tina M. 
Published: November 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Mixed Crystalline Precursor Complexes of the Type [Ba(C2H6O2)4] [Ti1‐xSnx (C2H4O2)3] (x = 0—1) for BaTi1‐xSnxO3 Ceramics: Synthesis, Structure and Calcination.
Authors: Koeferstein Roberto , Jaeger Lothar , Lorenz Volker , Abicht Hans‐Peter , Woltersdorf Joerg , Pippel Eckhard , Goerls Helmar 
Published: November 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Syntheses of Carbosilane Dendrimers Carrying Peripheral Globotriaose Derivatives — The Relationship Between the Carbosilane Dendrimer Structure and the Magnitude for Neutralizing Shiga Toxin‐Producing Escherichia coli O157:H7
Authors: Terunuma Daiyo , Matsuoka Koji , Hatano Ken 
Published: November 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Liquid‐Phase Synthesis of Polyamide Nucleic Acids (PNA): Applications in Targeting Specific Viral RNA Sequences
Authors: Di Giorgio C. , Depecker G. , Schwergold C. , Leroux M. L. , Caldarelli S. , Di Giorgio A. Farese , Patino N. , Condom R. 
Published: November 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Chromatographic analysis of allosteric effects between ibuprofen and benzodiazepines on human serum albumin
Authors: Chen Jianzhong , Fitos Ilona , Hage David S. 
Published: November 2005

AbstractThe effects of (R)‐ and (S)‐ibuprofen on the binding of benzodiazepines to human serum albumin (HSA) were examined by biointeraction chromatography. The displacement of benzodiazepines from HSA by (R)‐ and (S)‐ibuprofen was found to involve negative allosteric interactions (or possible direct competition) for most (R)‐benzodiazepines. However, (S)‐benzodiazepines gave positive or negative allosteric effects and direct competition when displaced by (R)‐ or (S)‐ibuprofen. Association equilibrium constants and coupling constants measured for these effects indicated that they involved two classes of ibuprofen binding regions (i.e., low‐ and high‐affinity sites). Based on these results, a model was proposed to explain the binding of benzodiazepines to HSA and their interactions with ibuprofen. This model gave good agreement with previous reports examining the binding of benzodiazepines to HSA. © 2005 Wiley‐Liss, Inc. Chirality
Chiral Recognition of Carboxylic Acids by Chiral Nitrogen Containing Calix[4]arene
Authors: Zheng Yan‐Song , Xiao Qin 
Published: November 2005

AbstractChiral nitrogen‐containing calix[4]arene was easily synthesized by the reaction of 25,27‐di(2‐bromoethoxy)‐26,28‐dihydroxy‐5,11,17,23‐tetrakis(t‐butyl)calix[4]arene with S‐((−)‐1‐phenylethylamine in excellent yield, and showed good ability to recognize the enantiomers of mandelic acid and 2,3‐dibenzoyltartaric acid. This finding has potential application to assay and separation of enantiomers of the carboxylic acids.
Novel Pd/TiO2‐Al2O3 Catalysts for Methane Total Oxidation at Low Temperature and Their 18O‐Isotope Exchange Behavior
Authors: Lin Wei , Lin Li , Zhu Yue‐Xiang , Xie You‐Chang , Scheurell K. , Kemnitz E. 
Published: November 2005

AbstractPd supported on TiO2‐Al2O3 binary oxides prepared by coprecipitation method has been investigated for the total oxidation of methane. All Pd/TiO2‐Al2O3 catalysts show higher activity than Pd/Al2O3 and Pd/TiO2. Among them, Pd/2Ti‐3Al with a Ti/Al ratio of 2 to 3 has a T90% of 395 °C at a gas hourly mass velocity of 33000 mL/(h·g), which is at least 50 °C lower than that of Pd supported on single metal oxide Al2O3 or TiO2. The results of TPR and 18O‐isotope exchange experiments demonstrated that the excellent activity of Pd/2Ti‐3Al was due to its high oxygen mobility and moderate reducibility, which is in accordance with our previous work. XPS results indicated that the dispersion of Pd was not the key factor to influence the catalytic activity.
Self‐assembly of Two Novel Supramolecular Frameworks Based on Flexible Oligo‐α‐Pyridylamino Ligands and Copper(II) Maleate
Authors: Zhou Cai‐Hua , Wang Yao‐Yu , Zhou Li‐Jun , Liu Ping , Li Dong‐Sheng , Shi Qi‐Zhen 
Published: November 2005

AbstractTwo novel supramolecular complexes, [Cu(bpapa)(mal)]·H2O·CH3OH (1) and {[Cu(bpapap)](Hmal)2}·2H2O (2) [bpapa=bis‐[6‐(2‐pyridylamino)pyrid‐2‐yl]amine, bpapap=2,6‐bis‐[6‐(pyrid‐2‐ylamino)pyrid‐2‐ylamino]‐pyridine, mal=maleate dianion] were rationally designed and synthesized based on flexible multidentate ligands and copper(II) maleate. Complexes 1 and 2 were all characterized by elemental analysis, spectroscopic techniques, thermal analysis and single crystal X‐ray diffraction analysis. Complex 1 is of an infinite 3‐D supramolecular framework constructed by 2‐D sheets to contain 1‐D helical chains formed by intermolecular hydrogen bond interactions between the non‐coordinated oxygen atoms from maleate and nitrogen atoms from amino groups of bpapa. Complex 2 also takes a 3‐D supramolecular structure, which is built from 2‐D rhombic sheets produced by sequential dimer units. Interestingly, three pairs of symmetrical hydrogen bonds generate these dimer units.
Preparation, Structural Characterization and Thermal Decomposition Mechanism of [Cu(TO)2(H2O)4](PA)2
Authors: Zhang Jian‐Guo , Zhang Tong‐Lai , Liu Yan‐Hong 
Published: November 2005

Abstract[Cu(TO)2(H2O)4](PA)2 was prepared by the reaction of aqueous 1,2,4‐triazol‐5‐one (TO) solution with the solution of copper picrate Cu(PA)2 and characterized by elemental analysis, FT IR and X‐ray powder diffraction analysis. The title complex has been studied by means of TG‐DTG and DSC under conditions of linear temperature increase. The thermal decomposition residues were examined by FT IR analysis. Thermal decomposition mechanism of the title complex was proposed. In the temperature range of 30–680 °C, the thermal decomposition process was composed of four major stages. The first stage was an endothermic process with the loss of four coordination water molecules. Since the dehydration product was unstable, when it was heated, it would be decomposed much more easily. The second stage was composed of an acute endothermic process and a continued strong exothermic process and the main decomposed residues were CuCO3, Cu(NCO)2 and polymers during this stage. The third stage was a sharp exothermic process, which resulted from the decomposition of the polymer. After the forth stage, the final decomposed residues were certainly copper oxide. The Arrhenius parameters have been also studied on the dehydration process and the first‐step exothermic decomposition of [Cu(TO)2(H2O)4](PA)2 using Kissinger's method and Ozawa‐Doyle's method. The results using both methods were consistent with each other. The Arrhenius equation can be expressed as ln k=24.0–179.8×103/RT for the dehydration process and ln k=16.7–206.0×103/RT for the first‐step exothermic decomposition, on the basis of the average of Ea and ln A through the two methods.
Syntheses, Structures and Antibacterial Activities of Two Nickel(II) Complexes with N‐Hexanoylsalicylhydrazide Ligand
Authors: Yang Ming‐Xing , Lin Shen , Yu Ping , Chen Li‐Juan , Liu Shi‐Xiong 
Published: November 2005

AbstractThe two trinuclear nickel(II) complexes, Ni3(C13H15N2O3)2(C5H5N)4 (1) and Ni3(C13H15N2O3)2(C5H5N)2‐ (C3H7NO)2 (2), were prepared by the reaction of Ni(OAc)2·4H2O with N‐hexanoylsalicylhydrazide. The crystal structures of complexes were determined by X‐ray diffraction analysis. Complex 1 takes triclinic symmetry with space group P‐1 and cell dimensions of a=0.92377(2) nm, b=1.08786(6) nm, c=1.29391(3) nm, α=76.395(4) °, β=78.418(3)°, γ=67.378(4)°, V=1.15772(7) nm3, Z=1, µ=12.63 cm−1. Complex 2 belongs to triclinic system and P2(1) space group and the crystallographic data: a=1.4889(2) nm, b=1.0389(1) nm, c=1.4994(2) nm, β=96.174(4)°, V=2.3058(5) nm3, Z=2, µ=12.70 cm−1. The structures of the two molecules are similar. The three nickel atoms in each molecule of the two title complexes arrange in a strictly linear structure. The central nickel atom of the molecule adopts octahedral configuration, while the two nickel atoms on the two sides adopt square‐planar configuration in each molecule. But the central nickel atoms of the two complexes have different axial ligands, which cause a slight difference in the bond distances of the octahedron. The antibacterial activity of compound 1 against seven common bacteria was investigated.
The First Total Synthesis of Phebaclavin A and C
Authors: Zhang Yu , Liu Dong , Li Yang , Cao Xiao‐Ping 
Published: November 2005

AbstractPhebaclavin A (1) and C (2) were synthesized in 60% and 58% total yields over 5 steps from commercially available starting meterials respectively. The synthesis feature was usage of the Wittig reaction twice and solvent‐free cyclizing reaction as the key steps.
Chiral Oxazaborolidine‐catalyzed Asymmetric Borane Reduction of Alkyl 4‐Dialkylaminophenyl Ketones
Authors: Xu Jia‐Xi , Lan Yu , Wei Tie‐Zheng , Zhang Qi‐Han 
Published: November 2005

AbstractA series of alkyl 4‐dialkylaminophenyl ketones were prepared and reduced asymmetrically by borane under the chiral oxazaborolidine catalysis. The results indicate that the ketones show a more obvious substituent effect on the enantioselectivity than the corresponding 4‐alkyl/alkoxy/alkylthiophenyl ketones in the asymmetric reduction because of the existence of a strong coordinate nitrogen atom with the boron atom in the catalyst and borane.
Aufklärung tut Not: Gefährliche Peroxide
Authors: Obendrauf Viktor 
Published: November 2005

AbstractDie im Folgenden thematisierten Fakten sind ausschließlich als Informationen für Lehrkräfte zu verstehen (siehe auch [1]). Von der Weitergabe dieses Beitrages im Rahmen von Facharbeiten an Lernende wird explizit abgeraten.
Die Erklärung der Brownschen Bewegung durch Einstein, Smoluchowski und Perrin
Authors: Jansen Walter 
Published: November 2005

AbstractÜber Albert Einstein, geboren am 14. März 1879 in Ulm und gestorben vor fünfzig Jahren am 18. April 1955 in Princeton (USA), ist gerade in diesem „Jubiläumsjahr”︁ ausführlichst geschrieben und berichtet worden. Denn es jährte sich nicht nur zum fünfzigsten Mal Einsteins Todesjahr, es ist auch genau 100 Jahre her, dass drei die Wissenschaft bewegende Arbeiten erschienen:˙Zur Theorie der Lichtquanten: Über einen die Erzeugung und Umwandlung des Lichtes betreffenden heuristischen Standpunkt [1]˙Zur Erklärung der Brownschen Bewegung: Über die von der molekularkinetischen Theorie der Wärme geforderte Bewegung von in ruhenden Flüssigkeiten suspendierten Teilchen [2] und die˙Spezielle Relativitätstheorie Zur Elektrodynamik bewegter Körper [3].Einsteins Tätigkeit im Schweizer Patentamt in Bern, wo er ab dem 16. Juni 1902 als Experte III. Klasse angestellt war, ließ ihm offensichtlich sehr viel Zeit, sich tiefschürfend mit wissenschaftlichen Fragestellungen zu beschäftigen.
Estimating late adverse events using competing risks after autologous stem‐cell transplantation in aggressive non‐Hodgkin lymphoma patients
Authors: Ruiz‐Soto Rodrigo , Sergent Guillaume , Gisselbrecht Christian , Larghero Jerome , Ertault Marjan , Hennequin Christophe , Manson Julien , de Kerviler Eric , Briere Josette , Mounier Nicolas 
Published: November 2005

AbstractBACKGROUNDConsolidative autologous stem‐cell transplantation (ASCT) is a valuable option in high‐risk or disease recurrence large‐cell non‐Hodgkin lymphoma patients (NHL); however, its long‐term toxicity must still be assessed.METHODSAmong the 439 lymphoma patients transplanted at our institution from January 1, 1993, to January 1, 2002, 158 exhibited aggressive NHL. The median age of the patients was 46 years (range, 18–69), 98 males and 60 females. Ninety (57%) patients received first‐line ASCT. The median number of prior chemotherapy regimens was 2 (range, 1–10). Thirty‐eight (24%) patients received total body irradiation conditioning. Here we report the adverse events which occurred at least 30 days after ASCT and before disease recurrence.RESULTSAfter a median follow‐up of 3 years, the overall and disease‐free survival rates were 61% and 55%, respectively. Sixty‐eight late adverse events affected 43 (27%) patients, leading to a cumulative incidence of 34% at 3 years. Infections were the most frequent adverse events (n = 13), followed by neurologic (n = 12), pulmonary (n = 6), or cardiovascular (n = 4). Eight malignancies were diagnosed (six solid, two hematologic), leading to a cumulative incidence of 3.7% at 3 years. Taking into account the competing risks, multivariate analysis revealed that the number of progressions (relative risk [RR] = 2.68) and a mitoxantrone‐containing conditioning regimen (RR = 2.98) significantly increased the incidence of late toxicity.CONCLUSIONASCT is effective in patients with aggressive NHL with a poor prognosis. However, careful long‐term follow‐up of survivors is recommended because of the increase in malignant and nonmalignant toxicities. Cancer 2005. © 2005 American Cancer Society.
Does maintenance/consolidation chemotherapy have a role in the management of small cell lung cancer (SCLC)?
Authors: Bozcuk Hakan , Artac Mehmet , Ozdogan Mustafa , Savas Burhan 
Published: November 2005

AbstractBACKGROUNDThe role of maintenance/consolidation chemotherapy was assessed in the management of small cell lung cancer (SCLC) via a metaanalytic approach.METHODSThe Medline and Cochrane databases were searched for relevant randomized clinical trials that compared maintenance chemotherapy with follow‐up. Quality of trials was assessed by European Lung Cancer Working Party (ELCWP) score. Odds ratios and rate differences were used as the effect size. Mantel–Haenszel tests with fixed and random effect models were conducted for 1‐ and 2‐year overall survival (OAS) and progression‐free survival (PFS).RESULTSFourteen relevant randomized clinical trials to date, encompassing 2550 patients, with trial sizes ranging from 36 to 610, were identified. Both 1‐ and 2‐year mortality were reduced with maintenance/consolidation chemotherapy. With the fixed model, odds ratios for 1‐ and 2‐year OAS were 0.67 (95% confidence interval [CI] = 0.56–0.79), P < 0.001, and also 0.67 (95% CI = 0.53–0.86), P < 0.001. Likewise, 1‐ and 2‐year PFS were better with maintenance/consolidation chemotherapy, with odds ratios of 0.49 (95% CI = 0.37–0.63), P < 0.001, and 0.64 (95% CI = 0.45–0.92), P < 0.015. The random model gave similar results. In accordance, maintenance chemotherapy improved 1‐ and 2‐year OAS by 9% (from 30–39%) and 4% (from 10–14%), respectively. Similarly, 1‐ and 2‐year PFS were also improved.CONCLUSIONMaintenance/consolidation chemotherapy improves survival in SCLC. New randomized clinical trials are needed to further refine the place of this approach in the management of SCLC. Cancer 2005. © 2005 American Cancer Society.