bluuebunny/crossref_metadata_2025_split huggingface dataset:
Axillary artery approach for balloon valvoplasty in young infants with severe aortic valve stenosis: Medium‐term results
Authors: Dua Jaspal S. , Osborne Nigel J.R. , Tometzki Andrew J.P. , Martin Robin P. 
Published: November 2006

AbstractObjectives: To assess the feasibility and results of trans‐axillary approach for balloon aortic valvoplasty (BAV) in early infancy. Background: Severe aortic valve stenosis (SAVS) is rare but serious condition in infancy, which may be promptly treated either by surgical aortic valvotomy or BAV. BAV is usually performed via the femoral artery route, which is associated with significant vascular complications and long procedure times. Methods: BAV via the trans‐axillary approach was performed on twenty‐seven sequential infants with SAVS presenting to a single tertiary referral center over an 11‐year period. Maximum inflated balloon size was less than or equal to the aortic valve diameter. Results: Twenty‐seven infants aged 1–77 days underwent BAV. Weight at time of procedure was 2.0–4.42 kgs. The median procedure and screening times were 82 and 7.9 minutes, respectively. Mean instantaneous Doppler gradient across the aortic valve reduced from 68 ± 33 to 37 ± 14 mmHg ( p < 0.0001). Three infants developed at least moderate aortic regurgitation. Right arm pulse volume was decreased in 12 infants; 5 received an intravenous heparin infusion. Longer‐term follow‐up demonstrated reduced or absent peripheral pulse in 5 infants. Transection of the axillary artery occurred in one infant requiring emergency microvascular repair. There was one post‐procedural and one late death due to non‐cardiac causes. Conclusions: In early infancy balloon aortic valvoplasty via the axillary artery approach for severe aortic stenosis is an acceptable and safe alternative to the femoral arterial approach and results in short procedure and screening times. Longer‐term vascular follow‐up is required. © 2006 Wiley‐Liss, Inc.
Incidental findings with cardiac CT evaluation—Should we read beyond the heart?
Authors: Budoff Matthew J. , Fischer Hans , Gopal Ambarish 
Published: November 2006

AbstractCardiac computed tomographic angiography (CTA) allows for simultaneous evaluation of the lung fields and associated structures. There is a debate as to the benefit of or need for routine overread of the lung fields for incidental findings. The possible improvement in cancer diagnosis with routine overreads is balanced against the major limitations of CT lung screening. Current limitations include (a) a high rate of nodule detection given that >50% of participants may have at least one noncalcified nodule; (b) the increased costs and radiation exposure associated with the resulting follow‐up CT scans; (c) the cost and the morbidity of follow‐up, including further testing, as well as biopsy or resection of benign noncalcified nodule (at least 25% of such procedures in several trials); (d) a small but difficult to quantify potential risk of cancer associated with multiple follow‐up CT scans; and (e) a potential for increased anxiety of both the patient and the physician about nonsignificant pathology. All of these limitations are balanced against a possibility that this could lead to an earlier detection of lung cancer with the consequent improvement in the chances of the patients' survival. Extensive studies of screening CT in older smokers have revealed the prevalence of cancer to be between 0.3 and 1%. However, when applied to an ambulatory population of patients presenting for an evaluation of angina, the prevalence of lung cancer or significant non‐cardiac findings may be significantly lower. We have reviewed all the relevant literature and sought to determine the potential benefits and harms of specifically overreading CTA for non‐cardiac pathology. The weight of the evidence suggests that it is most prudent to not specifically reconstruct and re‐read CTA scans for lung nodules. If a non‐cardiac abnormality is visualized by the primary interpreter of the cardiac CT, appropriate referral or follow‐up is prudent. © 2006 Wiley‐Liss, Inc.
Searching Inhibitors of Adenosine Kinase by Simulation Methods
Authors: Zhu Rui‐Xin , Zhang Xing‐Long , Dong Xi‐Cheng , Chen Min‐Bo 
Published: November 2006

AbstractSearching new inhibitors of adenosine kinase (AK) is still drawing attention of experimental scientists. A better and solid model is here proposed by means of simulation methods from different ways, the direct analysis of receptor itself, the conventional 3D‐QSAR methods and the integration of docking method and the conventional QSAR analysis.
How can the Cross‐Link Adducts Formed by Novel Trans Platinum Drug be Influenced by Hydrogen Bond
Authors: Chang Guan‐Ru , Zhou Li‐Xin , Chen Dong 
Published: November 2006

AbstractA systematic quantum chemical characterization of intrinsic structure, energies and spectral properties of all the studied cross‐link adducts formed by the novel trans platinum with thiazole ligand has been carried out at B3LYP/6‐31G* level of theory with the Lanl2dz pseudo potential basis set for the Pt atom. Special attention has been paid to the relative stability of these complexes and the factors that probably alter the order of the relative stability. The important influence of hydrogen bond on the structures, the energies and the spectral property was revealed. Other factors that contribute to relative stability including solvation effect, entropy and electronic delocalization energy were taken into account. The stability energy of the whole complex, and the interaction energy between two purine bases and the [Pt‐(NH3)thiazole]2+ group were adopted to study the interplay among subsystems and their contribution to relative stability of all the studied cross‐link model. Finally, basic spectral properties of these complexes including H(8) chemical shifts of all the studied complexes and the VCD (vibrational circular dichroism) spectra of two pairs of GG chelate enantiomers, were provided in order to define the structure of the most possible duplex bearing novel trans platinum drug lesions.
A New Amperometric Biosensor Based on HRP/Nano‐Au/L‐Cysteine/Poly(o‐Aminobenzoic acid)‐Membrane‐Modified Platinum Electrode for the Determination of Hydrogen Peroxide
Authors: Tang Ming‐Yu , Yuan Ruo , Xiao Qin 
Published: November 2006

AbstractThe third generation amperometric biosensor for the determination of hydrogen peroxide (H2O2) has been described. For the fabrication of biosensor, o‐aminobenzoic acid (oABA) was first electropolymerized on the surface of platinum (Pt) electrode as an electrostatic repulsion layer to reject interferences. Horseradish peroxidase (HRP) absorbed by nano‐scaled particulate gold (nano‐Au) was immobilized on the electrode modified with polymerized o‐aminobenzoic acid (poABA) with L‐cysteine as a linker to prepare a biosensor for the detection of H2O2. Amperometric detection of H2O2 was realized at a potential of +20 mV versus SCE. The resulting biosensor exhibited fast response, excellent reproducibility and sensibility, expanded linear range and low interferences. Temperature and pH dependence and stability of the sensor were investigated. The optimal sensor gave a linear response in the range of 2.99×10−6 to 3.55×10−3 mol·L−1 to H2O2 with a sensibility of 0.0177 A·L−1·mol−1 and a detection limit (S/N=3) of 4.3×10−7 mol·L−1. The biosensor demonstrated a 95% response within less than 10 s.
A Novel Synthesis of Bis‐(1,2,4‐triazolyl)‐3‐disulfides
Authors: Liu Tian‐Bao , Jiang Wen‐Qing , Zou Jian‐Ping , Zeng Run‐Sheng 
Published: November 2006

AbstractManganese triacetate was introduced as a new reagent for radical cyclization of substituted aminothioureas. Bis‐(1,2,4‐triazolyl)‐3‐disulfides were generated in 10 min under microwave irradiation.
Theoretical Design of High‐spin Organic Molecules with —·N—N— as a Spin‐containing Fragment and Heterocycles as an End Group
Authors: Chu De‐Qing , Wang Li‐Min , Zhang Jing‐Ping , Wang Rong‐Shun 
Published: November 2006

AbstractNovel stable high spin molecules possessing three different arranged fashions are designed with –·N–N< as a spin‐containing (SC) fragment, various aromatic, such as benzene (1), pyridine (2), pyridazine (3), pyrimidine (4), pyrazine (5), triazine (6) as end groups (EG) and phenyl as a ferromagnetic coupling (FC) unit. The effects of a different end groups on the spin multiplicities of the ground states and their stabilities were investigated by means of AM1‐CI approach. It has been found that the spin densities on the two atoms of the SC fragment are different from delocalization resulting in the specific stability of –·N–N<. In these molecules, the stabilities of the triplet states decrease when the distance between the atoms of central SC (–N–) increases. The orders of the stability of triplet states for 1an, 1bn, 1cn [They are isomers in which SC is connected with FC in different way (1an, N1NNN1; 1bn, N1N N1N; 1cn, NN1N1N) and six heterocycles are EG] show that the stability of triplet states with heterocycles as end groups is higher than that with phenyl as end groups, and in the order:triazine (EG)>pyrimidine, pyrazine>pyridine, pyridazine.
Selective α‐Bromination of β‐Keto Esters in Reusable PEG‐400 under Mild and Catalyst‐free Conditions
Authors: Xie Ye‐Xiang , Tang Shi , Zhu Qi‐Ming , Yin Du‐Lin , Li Jin‐Heng 
Published: November 2006

AbstractAn efficient bromination protocol for the synthesis of α‐bromo‐β‐keto esters has been developed. In PEG‐400 (poly(ethylene glycol‐400)), a variety of β‐keto esters were treated with NBS (N‐bromosuccinimide) at room temperature to selectively afford the corresponding α‐monobromination products in excellent yields. It is noteworthy that the reaction was conducted under mild, environmentally benign and catalyst‐free conditions.
Dicyano‐Functionalized MCM‐41‐Supported Palladium Complex as An Efficient Catalyst for Allylation of Aldehydes and Ketones
Authors: Zhao Hong , Cai Ming‐Zhong 
Published: November 2006

AbstractDicyano‐functionalized MCM‐41‐supported palladium complex was prepared from dicyano‐functionalized MCM‐41 and palladium chloride. This complex exhibited high catalytic activity in the allylation of aldehydes and ketones with allylic chlorides in the presence of SnCl2. This polymeric palladium complex can be recovered and reused without noticeable loss of activity.
Temperature prediction for multi‐dimensional domains in standard fire
Authors: Wang Zhi‐Hua , Tan Kang Hai 
Published: November 2006

AbstractThe existing 1D analytical solution for heat conduction inside structural members plays an important role in the estimation of temperature field and prediction of member strength in fire. In this paper, the novelty lies in a set of proposed analytical formulations for the conduction heat transfer within multi‐dimensional (2D and 3D) domains subjected to a particular time‐varying boundary condition, i.e. the standard fire conditions. Solutions of multi‐dimensional conduction are based on the eigenfunction approach using the technique of separation of variables. The multi‐dimensional effect is incorporated by the product of respective solutions of 1D transient heat conduction (1D step functions) of the plate and the infinite cylinder that serve as a set of basis for derivation of analytical solutions. Fire boundary conditions are incorporated using the Duhamel's principle, where the time‐varying fire temperature curve is imposed on the step functions. In this paper, the boundary conditions of the first and the third kind are considered, respectively. The analytical solutions are compared with results obtained from finite element analysis for verification. Copyright © 2006 John Wiley & Sons, Ltd.
A relational database for management of flow cytometry and ELISpot clinical trial data
Authors: Cavenaugh James S. , Snell Paul , Jeffries David , Waight Pauline A. , McConkey Samuel J. 
Published: November 2006

AbstractBackground:Although relational databases are widely used in bioinformatics with deposited and finalized data, they have not received widespread usage among immunologists for managing raw laboratory data such as that generated by ELISpot or flow cytometry assays. Almost no published guidance exists for immunologists to design appropriate and useful data management systems.Methods:We describe the design and implementation of a Microsoft Access relational database used in a clinical trial in which the primary immunogenicity measures were ELISpot and intracellular cytokine staining.Results:Our data management system enabled us to perform sophisticated queries and to interpret our data as quantitatively as possible. It could easily be used without modification by other researchers using automated plate reading of ELISpot plates or four color flow cytometry.Conclusions:We illustrate in detail the use of a flexible data management system for two of the most widely used immunological techniques. Minor modifications for more colors or other outputs can easily be implemented. Based on this example, other modifications could be easily envisaged for any other quantitative output. © 2006 International Society for Analytical Cytology
Mesoporous Nanocrystalline Mixed Metal Oxides from Heterometallic Alkoxide Precursors: Cobalt–Nickel Oxide Spinels for Propane Oxidation
Authors: Carreon Moises A. , Guliants Vadim V. , Yuan Li , Hughett Andrew R. , Dozier Alan , Seisenbaeva Gulaim A. , Kessler Vadim G. 
Published: November 2006

AbstractUniform nanocrystalline mesoporous mixed cobalt–nickel spinel phases displaying unimodal pores in the 7–12 nm range and relatively high specific surface areas up to 83 m2/g were prepared by a novel low temperature synthesis approach in which the desired metal oxide stoichiometries were introduced on a molecular level by reacting heterometallic alkoxide precursors in the presence of supramolecular liquid crystalline phases. The resultant phases, composed mainly of ca. 8–11 nm uniform cobalt–nickel spinel nanoparticles, were highly promising as low‐temperature hydrocarbon combustion catalysts investigated in a model reaction of propane oxidation. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)
The Proline‐Catalyzed Asymmetric Amination of Branched Aldehydes
Authors: Baumann Thomas , Vogt Henning , Bräse Stefan 
Published: November 2006

AbstractAn efficient access to configurationally stable α,α‐disubstituted α‐amino aldehydes, oxazolidinones, and α‐amino acids has been presented. Starting from simple and easily available racemic aldehydes, the α‐aminated products were obtained using azodicarboxylates as the nitrogen source in up to 86 % ee and moderate to excellent yield. These products could further be converted both into the corresponding α‐amino alcohols and, depending on the residue of the azodicarboxylates and the reaction conditions, into the oxazolidinones. On the other hand, oxidation towards the carboxylic acid and cleavage of the hydrazide bond under mild conditions revealed the free α‐alkylated phenylglycine derivative. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
Deletion of the chromatin remodeling gene SPT10 sensitizes yeast cells to a subclass of DNA‐damaging agents
Authors: Tounekti Kaouther , Aouida Mustapha , Leduc Anick , Poschmann Jeremie , Yang Xiaoming , Belhadj Omrane , Ramotar Dindial 
Published: November 2006

AbstractThe Saccharomyces cerevisiae SPT10 protein possesses a DNA‐binding domain that is fused to a putative histone acetyltransferase domain. It binds specifically to upstream‐activating sequence elements in the core histone promoters and plays a direct role in histone gene regulation. SPT10 is also required for cell‐cycle‐specific K56 acetylation at histone genes, allowing the recruitment of the nucleosome remodeling factor Snf5 and subsequent regulation of gene transcription. We reisolated the SPT10 gene in a functional genome‐wide screen designed to identify haploid yeast mutants that are hypersensitive to the antitumor drug bleomycin, which acts by damaging DNA. In addition to bleomycin, we show that spt10Δ mutants are also hypersensitive to a limited set of genotoxic agents that create DNA strand breaks, but not to 254‐nm ultraviolet light or 4‐nitroquinoline‐1‐oxide, which generate helix distortion. The hypersensitivities of the spt10Δ mutant to the genotoxic agents are rescued by a single copy plasmid carrying the SPT10 gene. We further showed that spt10Δ mutants displayed a modest twofold increase spontaneous mutant frequency, as compared to the parent. Following exposure to bleomycin, these mutants accumulate unrepaired lesions, e.g., DNA strand breaks with blocked 3′‐ends in the chromosomal DNA. This defect is not due to the altered expression level or the enzymatic activities of a key DNA repair enzyme, APN1, which is known to repair DNA strand breaks with blocked ends. We propose that SPT10 mediates repair of a subset of DNA lesions by acetylating histones to promote recruitment of DNA repair enzymes. Environ. Mol. Mutagen. 47:, 2006. © 2006 Wiley‐Liss, Inc.
Kolorimetrische Bestimmung des Dihydroxyacetons
Authors: Príbela A. 
Published: November 2006

AbstractDie kolorimetrische Methode zur Bestimmung von Dihydroxyaceton (DHA) gründet sich auf den Umsatz von DHA mit p‐Toluidin und Barbitursäure. Die entstehende gelb‐orange Verfärbung wird mittels eines geeigneten Colorimeters unter Benützung eines blauen Filters (476 nm) gemessen.Es werden 2 Alternativen der kolorimetrischen Arbeitsweise vorgeschlagen: In Anwesenheit von reduzierenden Zuckern bei 20°C, in reinen Systemen bei 80 °C. Wir berechneten die Gleichungen der Eichkurven und den Wahrscheinlichkeitsfehler der Konzentration für das Mittel der untersuchten Konzentrationsbereiche.Die kolorimetrische Arbeitsweise wird in ihren Ergebnissen mit denen nach der bisher benützten Titrations‐ und gravimetrischen Methode in reinen Systemen sowie in Anwesenheit von reduzierenden Zuckern verglichen. Das Titrations‐ und das kolorimetrische Verfahren bei 80 °C sind nur zur Bestimmung von reinen Lösungen des DHA geeignet, während die kolorimetrische Methode bei 20 °C das DHA auch in 1000‐fachem Überschuß an reduzierenden Zuckern zu bestimmen ermöglicht. Die gravimetrische Bestimmung ist wenig gut reproduzierbar. Die Empfindlichkeit der entwickelten Methode ist 20–200mal größer als die der Titrationsmethode und 100–1000mal größer als die der gravimetrischen Methode.
Über die rheologischen Eigenschaften der Bäckereiprodukte und Süßgebäcke
Authors: Kováts L. Telegdy , Lásztity R. , Major J. , Nedelkovits J. 
Published: November 2006

Abstract
Eine Analyse der rheologischen Eigenschaften von Bäckereiprodukten und Süßgebäcken zeigt, daß die totale Deformation einer Krume unter dem Einfluß einer Belastung durch zwei HOOKESCHE Elemente, zwei NEWTONsche Elemente und ein plastisches Element erklärt werden kann.
Es werden Faktoren diskutiert welche die rheologischen Eigenschaften der Krume von Brot und Biskuits beeinflussen. Festigkeit, Härte und Zähigkeit des fertigen Produktes werden durch Mehl, Milchtrockensubstanz und Eiweiß vergrößert, wogegen Zucker, Fette und Eidotter weniger feste Produkte ergeben. Backzeit und Lagerungsbedingungen können ebenfalls die rheologischen Eigenschaften verändern.
Biologische Wirkungen synthetischer Senfölbildner
Authors: Haenel H. 
Published: November 2006

AbstractUntersuchungen mit synthetischen Senfölbildnern erscheinen deshalb besonders interessant, weil sie als Modell für biologische Wirkungen von Phytonziden allgemein angesehen werden. Es wird insbesondere über zwei Verbindungen aus der Gruppe der Carbothialdine berichtet, bei denen nutritive Wirkungen an Hühnerküken und Kälbern sowie konservierende Wirkungen an Fischen festgestellt wurden. Es wurden ferner mikrobiologische Arbeiten durchgeführt (Ausbleiben von Resistenzsteigerungen bei Mikroorganismen nach häufig wiederholtem Kontakt mit den Verbindungen in vivo wie in vitro; größere Toxizität der Verbindungen unter aeroben als unter aneroben Züchtungsbedingungen); Versuche mit markierten Verbindungen ergaben schnelle Resorption, schnelle Ausscheidung zumeist als Sulfat, in geringen Anteilen in unveränderter Form als freies Senföl bzw. als Rhodanid. Die Verfütterung sehr hoher Dosen an Hühnerküken führte zu Wachstumsstillstand, Krankheitssymptome blieben aus.
Beitrag zur Chromatographie von Thiophosphorsäureestern, insbesondere von Tinox
Authors: Woggon H. , Spranger D. , Ackermann H. 
Published: November 2006

AbstractEs wird über ein neues Laufmittel berichtet, das Thiophosphorsäureester vom Typ Systox, insbesondere Tinox und dessen Metabolite einwandfrei trennt. Die vorgeschlagene Laufmittelkombination eignet sich sowohl für die papierchromatographische als auch für die dünnschicht‐chromatographische Trennung. Für letztere Methode wird die genaue Arbeitstechnik mitgeteilt. Der Vorteil gegenüber anderen Systemen liegt in den günstigeren Rf‐Werten von Tinox‐Sulfoxyd, dem eigentlichen Hauptmetaboliten bei der Rückstandsanalyse von Tinox. Die Nachweisgrenze liegt bei 1 μg/Fleck. Durch Anwendung der beschriebenen Dünnschichttechnik kann die Laufzeit auf 1 bis 11/2 Std. verkürzt werden.
Die δ‐Harze des Hopfens
Authors: Bausch H. A. , Rothenbach E. F. , Müke O. 
Published: November 2006

AbstractEine Modifikation der Methode von KUROIWA zur δ‐Harzbestimmung ergibt gegenüber der ursprünglichen Methode niedrigere Werte. Natürlich oder künstlich gealterter Hopfen besitzt einen höheren δ‐Harzgehalt als frischer Hopfen. Papierchromatographisch kann das δ‐Harz in mehrere Substanzen aufgetrennt werden. Die während der Pflückversuche im grünen Hopfen gefundenen δ‐Harzmengen liegen beträchtlich über den Werten für getrockneten Hopfen. Bei Trocknung der Hopfenzapfen fällt der δ‐Harzgehalt ab. Der Begriff δ‐Harz ist wie der des Hartharzes nicht eindeutig.
Über den Einfluß der Düngung auf einige Eigenschaften der Kartoffelstärke
Authors: Görlitz H. 
Published: November 2006

AbstractEs werden die Ergebnisse mehrjähriger Feldversuche über den Einfluß der Düngung auf bestimmte Eigenschaften der Kartoffelstärke zusammenfassend mitgeteilt. Als Kriterien werden herangezogen: Phosphorsäuregehalt, Viskosität (nach alkalischer Verkleisterung), Größenverteilung der Stärkekörner, Amylosegehalt sowie Verhältnis des Phosphorsäuregehaltes von Knollen und Stärke.
Ernährungshygienische Probleme durch Fütterung von Mastschweinen mit zinksulfathaltigem Eiweißfutter
Authors: Drux A. , Schreiter M. 
Published: November 2006

AbstractAusgehend vom natürlichen Vorkommen von Zink und seinen Salzen in Lebensmitteln und ihrer pharmakologischen Wirkung wird über Fütterungsversuche mit zinksulfathaltigem Knochenleim an Mastschweinen berichtet. Die unter „normalen”︁ Bedingungen mit üblichem zinksulfathaltigen Knochenleim gefütterten Schweine ließen einen erhöhten Zinkgehalt im Fleisch nicht erkennen; dasselbe kann also zur menschlichen Ernährung Verwendung finden.
Synthese neuer Verbindungen im Zusammenhang mit der Bienenköniginnensubstanz
Authors: Grohmann F. , Schmid L. 
Published: November 2006

AbstractUnter Hinweis auf die im Sekret der Bienenköniginnen nachgewiesene Substanz, die 9‐Oxotransdecen‐(2)‐säure‐(1), bei der man die Wirkung eines Pheromons vermutet, wird eine Reihe von homologen Verbindungen dargestellt, die sich gründen auf folgende Substanzen: 7‐Oxo‐octen‐(2)‐säure‐(1), 7‐Oxo‐decen‐(2)‐säure‐(1), 10‐Oxo‐undecen‐(2)‐säure‐(1); 9‐Oxo‐transdecen‐(2)‐säure‐1‐isoamylamid, ‐benzylamid und ‐piperidid; Nonen‐(2)‐disäure‐1‐methylester‐9‐dimethylamid, ‐piperidid, ‐methylthioester, ‐n‐butylthioester.