bluuebunny/crossref_metadata_2025_split huggingface dataset:
Can we apply the dual‐pathway model of overeating to a population of weight‐preoccupied overweight women?
Authors: Gagnon‐Girouard Marie‐Pierre , Bégin Catherine , Provencher Véronique , Tremblay Angelo , Boivin Sonia , Lemieux Simone 
Published: November 2008

AbstractObjective:The aim of the study is to verifythe applicability of the dual‐pathwaymodel among weight‐preoccupied overweight women and to document the restraint pathway, the negative affect pathway, and the possibility of a direct pathway from body dissatisfaction to overeating.Method:Structural equations were performed to test the model on baseline data of 153 weight‐preoccupied overweight women recruited to participate in a randomized trial.Results:Findings suggest that the model obtains satisfactory fit. Although the restraint pathway is partially supported, the negative affect pathway is confirmed. A third pathway linking directly body dissatisfaction to overeating is also evidenced.Discussion:The dual‐pathway model of overeating seems to be representative of the reality of weight‐preoccupied overweight women, which could be pointed as a population in need of clinical attention, particularly considering the dramatically increasing rates of obesity. © 2008 by Wiley Periodicals, Inc. Int J Eat Disord 2009
Implementing the EU Water Framework Directive – prospects for sustainable water planning in Sweden
Authors: Hedelin Beatrice , Lindh Magnus 
Published: November 2008

AbstractImplementation of the EU Water Framework Directive will significantly affect the way in which water issues in Europe are managed. Here, a set of criteria for processes for sustainable river basin planning is used as a basis for analysing how the responsible planners in one EU member state – Sweden – carry out the work prescribed by the WFD. The paper is based on 13 interviews with water planners and directors. The current processes represent progress in relation to the situation pertaining before implementation; e.g., participation and collaboration are increasingly becoming pivotal, knowledge of the natural water state is increasing and the economy of water is emerging as a new and important issue. The interviews do however show that knowledge of how to work with values and how to create forms and methods of participation and collaboration remain clearly underdeveloped. In consequence, the main objectives behind participation – the provision of knowledge and perspectives for the process and the creation of legitimacy, acceptance or engagement – are actually at risk. Recommendations include complementing the existing knowledge base with insights from the social sciences and the humanities, to create well informed learning systems within the new water administration and to make use of alternative methods for the handling of values. The Swedish case may provide useful insights for other member states. Copyright © 2008 John Wiley & Sons, Ltd and ERP Environment.
Hydrothermal Synthesis of Three‐Dimensional Hierarchical CuO Butterfly‐Like Architectures
Authors: Zhang Yajing , Or Siu Wing , Wang Xiaolei , Cui Tieyu , Cui Weibin , Zhang Ying , Zhang Zhidong 
Published: November 2008

AbstractUniform 3D hierarchical CuO butterfly‐like architectures were fabricated by a surfactant‐assisted hydrothermal oriented attachment route. This route included the formation of CuO butterfly‐like architectures in a solution of cupric chloride (CuCl2·2H2O) and sodium hydroxide (NaOH) at 100 °C for 15 h by using sodium dodecyl benzenesulfonate (SDBS) as surfactant. The as‐prepared CuO architecture was characterized by X‐ray diffraction, scanning electron microscopy and transmission electron microscopy. The CuO butterfly‐like architectures, with lengths of about 6 μm and widths of 2–4 μm, were assembled from several tens of oriented attachment rhombic nanosheets with a thickness of about 60 nm. A growth mechanism for the formation of the CuO butterfly‐like architectures was proposed on the basis of time‐dependent experiments. The synthetic parameters such as reaction temperature, the concentration of sodium hydroxide and reaction time all affected the morphology of the CuO architectures. The synthetic strategy could be extended to assemble 3D architectures of other materials.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Paracyclophanes: Extending the Bridges. Synthesis
Authors: Pechlivanidis Zissis , Hopf Henning , Ernst Ludger 
Published: November 2008

AbstractPreparatively satisfactory routes to [3.2]paracyclophane (10), [4.2]paracyclophane (14), [4.3]paracyclophane (19) as well as several derivatives of these compounds – among others the bromides 25, the ester 31, the diesters 40–43 – are described using well‐established methods of cyclophane chemistry (ring‐closure reactions leading to thiacyclophanes, ring contraction by sulfone pyrolysis). The parent systems and their derivatives are now available in gram quantities allowing a study of their chemical properties.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Efficient and Stereodivergent Syntheses of D‐ and L‐Fagomines and Their Analogues
Authors: Kumari Nitee , Reddy B. Gopal , Vankar Yashwant D. 
Published: November 2008

AbstractThe syntheses of D‐ and L‐fagomines 1, 4, 5 and 6 and their isomers from starting D‐glycals have been achieved. The syntheses involve elaboration of common amino alcohol precursors obtained from 2‐deoxy‐1‐amino sugar derivatives. The key steps in the syntheses are intramolecular reductive amination and intramolecular N‐heterocyclization. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Palladium‐Catalyzed Coupling Reactions of Diarylvinylidenecyclopropanes with 2‐Iodophenol and N‐(2‐Iodophenyl)‐4‐methylbenzenesulfonamide
Authors: Li Wei , Shi Min 
Published: November 2008

AbstractA palladium‐catalyzed cross‐coupling reaction of diarylvinylidenecyclopropanes with 2‐iodophenol and N‐(2‐iodophenyl)‐4‐methylbenzenesulfonamide provided a variety of cyclopropane‐containing 2,2‐diaryl‐3‐tetramethylcyclopropylidene‐2,3‐dihydrobenzofuran and 2,2‐diaryl‐3‐tetramethylcyclopropylidene‐1‐(toluene‐4‐sulfonyl)‐2,3‐dihydro‐1H‐indole derivatives in moderate‐to‐good yields.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
A Novel Approach to Combretastatins: From trans‐Epoxide to CA‐4 and Its Dioxolane Derivative
Authors: Lupattelli Paolo , D'Auria Maurizio , Di Blasio Nadia , Lenti Francesca 
Published: November 2008

AbstractThe trans‐epoxide derivative of Combretastatin A‐4 wasstereoselectively prepared in good yield by sulfur ylide mediated epoxidation of silyl‐protected isovanillin. From this key intermediate, a formal synthesis of CA‐4, by stereoselective deoxygenation and photoisomerization, was achieved. Alternatively, a trans‐dioxolane derivative was obtained bystereoselective acetone insertion.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
MicroRNA-101 regulates expression of the v-fos FBJ murine osteosarcoma viral oncogene homolog (FOS) oncogene in human hepatocellular carcinoma #
Authors: Li Shuai , Fu Hanjiang , Wang Yulan , Tie Yi , Xing Ruiyun , Zhu Jie , Sun Zhixian , Wei Lixin , Zheng Xiaofei 
Published: November 2008

Abstract
MicroRNAs (miRNAs) have recently been proposed as a versatile class of molecules involved in regulation of various biological processes. Although there is emerging evidence that some microRNAs can function as oncogenes or tumor suppressors, the specific role of miRNA in human hepatocellular carcinoma (HCC) is unclear at this point. In this study, we examined the microRNA expression profiles in a set of 20 human HCC specimens by miRNA microarray and quantitative real-time polymerase chain reaction. The results showed that among the 20 HCC samples analyzed, microRNA-101 was significantly down-regulated twofold or more (twofold to 20-fold) in 16 samples compared with the matching nontumoral liver tissues. Using both a luciferase reporter assay and Western blot analysis, we showed that microRNA-101 repressed the expression of v-fos FBJ murine osteosarcoma viral oncogene homolog (FOS) oncogene, a key component of the activator protein-1 (AP-1) transcription factor. Moreover, using a luciferase expression vector (pAP-1-Luc) driven by seven copies of an AP-1 cis-element, we observed that microRNA-101 expression inhibited phorbol 12-myristate 13-acetate (PMA)–induced AP-1 activity. In in vitro Matrigel invasion and Transwell migration assays, enhanced microRNA-101 expression inhibited the invasion and migration of cultured HCC cells, respectively. These findings suggest that microRNA-101 may play an important role in HCC. Conclusion: MicroRNA-101, which is aberrantly expressed in HCC, could repress the expression of the FOS oncogene. (Hepatology 2009.)
Beneficial effects of sorafenib on splanchnic, intrahepatic, and portocollateral circulations in portal hypertensive and cirrhotic rats #
Authors: Mejias Marc , Garcia-Pras Ester , Tiani Carolina , Miquel Rosa , Bosch Jaime , Fernandez Mercedes 
Published: November 2008

Abstract
Portal hypertension, the most important complication in patients with cirrhosis of the liver, is a serious and life-threatening disease for which there are few therapeutic options. Because angiogenesis is a pathological hallmark of portal hypertension, the goal of this study was to determine the effects of sorafenib—a potent inhibitor of proangiogenic vascular endothelial growth factor receptor 2 (VEGFR-2), platelet-derived growth factor receptor β (PDGFR-β), and Raf kinases—on splanchnic, intrahepatic, systemic, and portosystemic collateral circulations in two different experimental models of portal hypertension: rats with prehepatic portal hypertension induced by partial portal vein ligation and rats with intrahepatic portal hypertension and secondary biliary cirrhosis induced by bile duct ligation. Such a comprehensive approach is necessary for any translational research directed toward defining the efficacy and potential clinical application of new therapeutic agents. Sorafenib administered orally once a day for 2 weeks in experimental models of portal hypertension and cirrhosis effectively inhibited VEGF, PDGF, and Raf signaling pathways, and produced several protective effects by inducing an approximately 80% decrease in splanchnic neovascularization and a marked attenuation of hyperdynamic splanchnic and systemic circulations, as well as a significant 18% decrease in the extent of portosystemic collaterals. In cirrhotic rats, sorafenib treatment also resulted in a 25% reduction in portal pressure, as well as a remarkable improvement in liver damage and intrahepatic fibrosis, inflammation, and angiogenesis. Notably, beneficial effects of sorafenib against tissue damage and inflammation were also observed in splanchnic organs. Conclusion: Taking into account the limitations of translating animal study results into humans, we believe that our findings will stimulate consideration of sorafenib as an effective therapeutic agent in patients suffering from advanced portal hypertension. (Hepatology 2009.)
Evaluation and prediction of on‐line maintenance workload in nuclear power plants
Authors: Liang Guo‐Feng , Lin Jhih‐Tsong , Hwang Sheue‐Ling , Huang Fei‐hui , Yenn Tzu‐Chung , Hsu Chong‐Cheng 
Published: November 2008

AbstractThis study evaluates engineers' mental workload while maintaining digital systems in nuclear power plants (NPPs). First, according to the factors affecting the mental workload, a questionnaire was designed to evaluate the mental workload of maintenance engineers at the Second NPP in Taiwan. Then 16 maintenance engineers from the Second NPP participated in the experiment survey. The results indicated that the mental workload was lower in maintaining digital systems than that in analog systems. Finally, a mental workload model based on the neural network technique was established to predict the mental workload of maintenance engineers in maintaining digital systems. Through predicting mental workload, the manager can organize the human resources for each daily task to sustain the appropriate mental workload as well as improve maintenance performance. © 2008 Wiley Periodicals, Inc.
Interesting properties of Thomas–Fermi kinetic and Parr electron–electron‐repulsion DFT energy functional generated compact one‐electron density approximation for ground‐state electronic energy of molecular systems
Authors: Kristyan Sandor 
Published: November 2008

AbstractThe reduction of the electronic Schrodinger equation or its calculating algorithm from 4N‐dimensions to a (nonlinear, approximate) density functional of three spatial dimension one‐electron density for an N‐electron system, which is tractable in the practice, is a long desired goal in electronic structure calculation. If the Thomas‐Fermi kinetic energy (∼∫ρ5/3dr1) and Parr electron–electron repulsion energy (∼∫ρ4/3dr1) main‐term functionals are accepted, and they should, the later described, compact one‐electron density approximation for calculating ground state electronic energy from the 2nd Hohenberg–Kohn theorem is also noticeable, because it is a certain consequence of the aforementioned two basic functionals. Its two parameters have been fitted to neutral and ionic atoms, which are transferable to molecules when one uses it for estimating ground‐state electronic energy. The convergence is proportional to the number of nuclei (M) needing low disc space usage and numerical integration. Its properties are discussed and compared with known ab initio methods, and for energy differences (here atomic ionization potentials) it is comparable or sometimes gives better result than those. It does not reach the chemical accuracy for total electronic energy, but beside its amusing simplicity, it is interesting in theoretical point of view, and can serve as generator function for more accurate one‐electron density models. © 2008 Wiley Periodicals, Inc. J Comput Chem 2009
Modeling the H bond donor strength of OH, NH, and CH sites by local molecular parameters
Authors: Schwöbel Johannes , Ebert Ralf‐Uwe , Kühne Ralph , Schüürmann Gerrit 
Published: November 2008

AbstractA quantum chemical model is introduced to predict the H‐bond donor strength of monofunctional organic compounds from their ground‐state electronic properties. The model covers OH, NH, and CH as H‐bond donor sites and was calibrated with experimental values for the Abraham H‐bond donor strength parameterAusing theab initioand density functional theory levels HF/6‐31G** and B3LYP/6‐31G**. Starting with the Morokuma analysis of hydrogen bonding, the electrostatic (ES), polarizability (PL), and charge transfer (CT) components were quantified employing local molecular parameters. With hydrogen net atomic charges calculated from both natural population analysis and the ES potential scheme, the ES term turned out to provide only marginal contributions to the Abraham parameterA, except for weak hydrogen bonds associated with acidic CH sites. Accordingly,Ais governed by PL and CT contributions. The PL component was characterized through a new measure of the local molecular hardness at hydrogen, η(H), which in turn was quantified through empirically defined site‐specific effective donor and acceptor energies,EEoccandEEvac. The latter parameter was also used to address the CT contribution toA. With an initial training set of 77 compounds, HF/6‐31G** yielded a squared correlation coefficient,r2, of 0.91. Essentially identical statistics were achieved for a separate test set of 429 compounds and for the recalibrated model when using all 506 compounds. B3LYP/6‐31G** yielded slightly inferior statistics. The discussion includes subset statistics for compounds containing OH, NH, and active CH sites and a nonlinear model extension with slightly improved statistics (r2= 0.92). © 2008 Wiley Periodicals, Inc. J Comput Chem 2009
MicroRNAs: Novel Regulators During the Immune Response
Authors: Bi Yujing , Liu Guangwei , Yang Ruifu 
Published: November 2008

AbstractMicroRNAs (miRNAs), an abundant class of highly conversed, small noncoding RNAs, present an entirely new way of post‐transcriptional gene regulation. miRNAs play a key role in diverse biological processes, such as embryogenesis, differentiation, inflammation, viral infections, and carcinogenesis. Recently, more studies showed the importance of these noncoding small RNAs on immune system development and response, and miRNAs are found to involve in the regulation of immunity, including the development and differentiation of immnue cells, antibody production and the inflammatory mediator release. Here, the latest findings were summarized to explore the function and mechanism of miRNAs in modulating innate and adaptive immune responses. J. Cell. Physiol. 218: 467–472, 2009. © 2008 Wiley‐Liss, Inc.
Novel caffeic acid ester derivative induces apoptosis by expressing fasl and downregulating NF‐KappaB: Potentiation of cell death mediated by chemotherapeutic agents
Authors: Bose Julie S. , Gangan Vijay , Jain Swatantra K. , Manna Sunil K. 
Published: November 2008

AbstractIn the present study, we demonstrate the biological activity of esterified caffeic acid with methyl vanillate also termed as caffeic acid methyl vanillate ester (CAMVE). CAMVE potentiates TNF‐induced cell death as analyzed by cell viability assay and blocks inflammatory stimuli‐induced nuclear transcription factor kappaB (NF‐κB) activation and NF‐κB‐dependent genes expression. CAMVE‐mediated inhibition of NF‐κB or induction of cell death is not cell type specific. CAMVE inhibits cell proliferation by inhibiting G1 to S phase progression. It suppresses TNF‐induced Bcl‐2 expression and potentiates chemotherapeutic agents‐mediated cell death. CAMVE enhances intracellular free Ca2+ and thereby activates calcineurin. Calcineurin, in turns, activates nuclear transcription factor NF‐AT and its dependent genes such as FasL, which induces cell death. The data demonstrate that CAMVE is one of the combinatorial products, which is able to inhibit NF‐κB regulated genes and cell proliferation. The combinatorial synthesis of novel caffeic ester derivatives can be a useful approach to generate potent chemotherapeutic agents and designing CAMVE as potent therapeutic agent for combination therapy may be useful to treat tumors. J. Cell. Physiol. 218: 653–662, 2009. © 2008 Wiley‐Liss, Inc.
Unusual sonographic appearance of synovial sarcoma of the anterior abdominal wall
Authors: Kishino Tomonori , Morii Takeshi , Mochizuki Kazuo , Sudo Emi , Hirano Kazuhiko , Okazaki Mitsuhiro , Ohtsuka Kouki , Ohnishi Hiroaki , Kurihara Shuichi , Tsuneyoshi Masazumi , Fujioka Yasunori , Watanabe Takashi 
Published: November 2008

AbstractWe report a case of synovial sarcoma in a 58‐year‐old woman arising from the anterior abdominal wall. Sonography demonstrated a large mass with an unusual complex “honeycomb” echotexture. Doppler imaging displayed increased vascularity in the solid parts of the tumor. © 2008 Wiley Periodicals, Inc. J Clin Ultrasound, 2009
The role of transformational leadership, emotional intelligence, and group cohesiveness on leadership emergence
Authors: López‐Zafra Esther , Garcia‐Retamero Rocio , Landa José M. Augusto 
Published: November 2008

AbstractThe concept of emotional intelligence and its connections with other important psychological constructs have been the focus of a wide range of current research (see Mestre & Fernández‐Berrocal, 2007, and Salovey, Woolery, & Mayer, 2001, for reviews). Yet the relationship between emotional intelligence and transformational leadership, a leadership style that is highly correlated with efficiency and satisfaction of the leaders' followers, has scarcely been analyzed. We hypothesize that individuals who score high in emotional intelligence emerge as leaders more easily than low‐emotional‐intelligence individuals due to the fact that they are more transformational in their leadership style. We further suggest that this is especially the case in highly cohesive groups. In this study, we test these ideas and find empirical support for our hypotheses.
Hydroxycarbonyl anion (m/z 45), a diagnostic marker for α‐hydroxy carboxylic acids
Authors: Bialecki Jason B. , Axe Frank U. , Attygalle Athula B. 
Published: November 2008

AbstractCollision‐induced dissociation mass spectra of anions derived from α‐hydroxy carboxylic acids (AHAs) show a diagnostic peak at m/z 45. Product ion spectra recorded from this m/z 45 ion confirm that it represents the hydroxycarbonyl anion (magnified image), and not the formate anion (magnified image) as sometimes described in the literature. For example, the formate anion is not only defiant to further fragmentation but is also unreactive toward CO2. In contrast, the hydroxycarbonyl anion easily fragments to produce a peak at m/z 17 for the hydroxyl anion, and also readily reacts with CO2 to produce a peak at m/z 61 for the bicarbonate anion. The hydrogen atom in the hydroxycarbonyl anion and that in the formate anion are not mobile within the skeletal framework of the ions, since the two ions did not manifest any interconversion under the conditions and time scales of our mass spectrometric experiments. The other significant product ion peak in the spectra of deprotonated AHAs represents a 46‐Da loss. MS/MS data from appropriately deuteriated compounds confirmed that one hydrogen atom from the C‐2 position, and the other from the hydroxy group are specifically removed for this loss of elements of formic acid. Moreover, the two oxygen atoms eliminated for the HCOOH loss originate exclusively from the carboxylate group. Copyright © 2008 John Wiley & Sons, Ltd.
Study of binding affinity and selectivity of perylene and coronene derivatives towards duplex and quadruplex DNA by ESI‐MS
Authors: Casagrande Valentina , Alvino Antonello , Bianco Armandodoriano , Ortaggi Giancarlo , Franceschin Marco 
Published: November 2008

AbstractIn this paper, we report an extensive electrospray ionization mass spectrometry (ESI‐MS) study of the noncovalent interactions between different intermolecular and intramolecular G‐quadruplex structures and several perylene and coronene ligands. The selectivity of these compounds toward quadruplex structures with respect to duplex DNA, a fundamental topic for the biological evaluation and the pharmacological application of these ligands as potential chemotherapeutic agents, has also been investigated. After exploring this topic according to the classical approach based on the very simple duplex model of an autocomplementary dodecamer, we extended our analysis reporting for the first time a competition ESI‐MS experiment in the presence of genomic DNA fragments. Whereas those ligands showing a high level of selectivity between quadruplex and duplex oligonucleotides, in terms of binding constants and percentage of bound DNA, confirmed their selectivity in the competition experiment, the contrary was not always true: some ligands showing poor selectivity with the autocomplementary dodecamer resulted selective in the presence of genomic DNA fragments. This result suggests that physiologically nonrelevant interactions are possible with a short duplex oligonucleotide. This means that the dodecamer can fail in representing a biologically significant structural model, or, better, that it can be used to quickly screen potentially selective molecules, but bearing in mind the high probability of false negative results. Copyright © 2008 John Wiley & Sons, Ltd.