bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship of B‐type natriuretic peptide and anemia in patients with and without heart failure: A substudy from the Breathing Not Properly (BNP) Multinational Study
Authors: Wu Alan H.B. , Omland Torbjørn , Wold Knudsen Cathrine , McCord James , Nowak Richard M. , Hollander Judd E. , Duc Philippe , Storrow Alan B. , Abraham William T. , Clopton Paul , Maisel Alan S. , McCullough for the Breathing Not Properly Multinational Stud Peter A. 
Published: October 2005

AbstractWhile anemia is a significant risk factor for poor outcomes in patients with heart failure (HF), it is not in defined guidelines for HF assessment. B‐type natriuretic peptide (BNP) is a marker for diagnosis and management of patients with HF. We determined the incidence of anemia in patients with HF and the relationship between BNP and hemoglobin (Hgb) levels in patients with and without HF. Results from the Breathing Not Properly Multinational Trial consisted of 1586 patients presenting to the emergency department (ED) with dyspnea. Because renal insufficiency is a confounding variable for BNP, patients with a creatinine of ≥2.0 mg/dL were excluded. The remaining data were evaluated from 620 non‐HF patients (337 M, 283 F) and 547 HF patients (299 M, 248 F). The New York Heart Association (NYHA) HF classification and ejection fraction by echocardiography were assessed for HF patients. Blood was tested for Hgb, BNP, and creatinine. Using World Health Organization criteria for anemia, we observed that HF patients in NYHA class III or IV had lower mean Hgb levels (12.5 g/dL, P < 0.05) and a higher incidence of anemia (48.2%, P < 0.05) than did HF patients in class I or II (13.4 g/dL and 33.9%, respectively). There was no correlation between Hgb and log BNP for females without HF or the aggregate of all HF patients. In contrast, a significant inverse correlation was observed for males without HF (P < 0.001). Although there were differences in the BMI, age, and estimated glomerular filtration rate (eGFR) versus Hgb observed in this group, the log BNP correlation remained significant after multivariate analysis. A significant inverse correlation for log BNP and Hgb were also observed for diastolic (EF ≥ 50) HF (P < 0.05) that was also not accounted for by the BMI, age, or eGFR. The presence of anemia is associated with worsening HF at ED presentation. For males without HF and diastolic HF patients of both genders, a low Hgb may be a confounding variable toward increasing BNP. Among systolic HF patients, the presence of a low hemoglobin concentration is not a factor in the interpretation of BNP results. Am. J. Hematol. 80:174–180, 2005. © 2005 Wiley‐Liss, Inc.
von Willebrand disease R1374C: Type 2A or 2M? A challenge to the revised classification. High frequency in the northwest of Spain (Galicia)
Authors: Penas Norma , Pérez‐Rodríguez Almudena , Torea Jorge Horacio , Lourés Esther , Noya María Soledad , López‐Fernández María Fernanda , Batlle Javier 
Published: October 2005

AbstractPatients initially diagnosed with type 1 von Willebrand disease (VWD) have been reclassified as type 2 after a more exhaustive analysis in several studies. Our study's objectives were (1) to reanalyze patients that were previously diagnosed as type 1 to achieve a more accurate diagnosis and (2) to compare the von Willebrand factor (VWF) ristocetin cofactor assay (VWF:RCo) and the VWF collagen binding assay (VWF:CB) in order to evaluate the possibility of replacing the former assay with the latter in the diagnosis of VWD. Twenty‐one patients from two large unrelated families and 104 normal controls were studied. VWF:Ag, VWF:RCo, FVIII coagulant activity (FVIII:C), bleeding time (BT), PFA100, and multimeric analysis of VWF were tested. Genetic analysis by sequencing exon 28 on the VWF gene was also carried out. Patients presented lower levels of VWF:Ag and VWF:RCo, a dissociation between VWF:RCo/VWF:Ag, and the presence of all sizes of multimers in plasma VWF. The results for VWF:CB varied depending on the type of collagen used. The genetic analysis showed that the mutation R1374C is responsible for type 2M VWD. A high frequency of the R1374C mutation is observed in northwestern Spain (Galicia). Some types of 2M VWD are misdiagnosed as type 1 VWD. The VWF:CB (with type I collagen) assay was unable to discriminate defective platelet binding of the R1374C VWF. This confirms that VWF:CB cannot substitute for VWF:RCo, and both should be tested when diagnosing VWD. Am. J. Hematol. 80:188–196, 2005. © 2005 Wiley‐Liss, Inc.
Guidance on the use of miglustat for treating patients with type 1 Gaucher disease
Authors: Weinreb Neal J. , Barranger John A. , Charrow Joel , Grabowski Gregory A. , Mankin Henry J. , Mistry Pramod 
Published: October 2005

AbstractType 1 Gaucher disease (GD) is a progressive lysosomal storage disorder due to an autosomal recessive deficiency of glucocerebrosidase. Clinical manifestations include anemia, thrombocytopenia, hepatosplenomegaly, and bone and pulmonary disease. Intravenous enzyme replacement (ERT) with imiglucerase is the accepted standard for treatment of symptomatic patients. More than 3,500 patients worldwide have received ERT with well‐documented beneficial effects on the hematological, visceral, skeletal, and pulmonary manifestations, and with resultant improvement in health‐related quality of life. Miglustat, an imino sugar that reversibly inhibits glucosylceramide synthase and reduces intracellular substrate burden, is an oral treatment for patients with type 1 GD that was recently approved in the United States for symptomatic patients with mild to moderate clinical manifestations for whom ERT is not an option. Because responses to miglustat are slower and less robust than those observed with ERT, and because miglustat is associated with significant side effects, clinicians who care for patients with GD should become familiar with the limited indications for miglustat use and the circumstances when it may be prescribed appropriately. This review article and position statement represents the current opinion of American physicians with extensive expertise in GD regarding patient management in the context of the availability of standard imiglucerase treatment and the recent introduction of miglustat. Am. J. Hematol. 80:223–229, 2005. © 2005 Wiley‐Liss, Inc.
Evidence that interaction between neuregulin 1 and its receptor erbB4 increases susceptibility to schizophrenia
Authors: Norton Nadine , Moskvina Valentina , Morris Derek W , Bray Nicholas J , Zammit Stanley , Williams Nigel M , Williams Hywel J , Preece Anna C , Dwyer Sarah , Wilkinson Jennifer C , Spurlock Gillian , Kirov George , Buckland Paul , Waddington John L , Gill Michael , Corvin Aiden P , Owen Michael J , O'Donovan Michael C 
Published: October 2005

AbstractThere is now strong evidence that Neuregulin 1 (NRG1) is a susceptibility gene for schizophrenia. NRG1 mediates some of its effects through the tyrosine kinase receptor erbB4, and analysis of gene knock‐out animals suggests that the functional interaction of NRG1 and erbB4 mediates behaviors that may model some aspects of the schizophrenia phenotype in mice. Given these findings, we have sought evidence for association between schizophrenia and erbB4. Mutation screening of erbB4 in 14 DSMIV schizophrenics revealed 15 SNPs, none of which were nonsynonymous. Analysis of the allele frequencies of each SNP in pools of 368 DSMIV schizophrenics and 368 controls provided modest evidence for association with two of the SNPs, although individual genotyping in an extended sample of 680 cases did not confirm this. However, we did find evidence for a significant interaction between the NRG1 “Icelandic” schizophrenia risk haplotype and erbB4 (P = 0.019). The NRG1 and erbB4 interacting marker was further genotyped in an independent sample of 290 cases and 634 controls from Dublin. Interaction between NRG1 and erbB4 remained significant in the combined sample of 970 cases and 1,341 controls, OR = 2.98 (CI: 1.16–7.64), P = 0.01, although it only showed a trend in the Dublin sample alone (P = 0.11, two tailed). Our data require independent replication, but tentatively suggest that NRG1 may mediate its effects on schizophrenia susceptibility through functional interaction with erbB4, and that genetic interaction between variants at the two loci increases susceptibility to schizophrenia. © 2005 Wiley‐Liss, Inc.
Lanthanide borohydrido complexes for MMA polymerization: syndio‐ vs iso‐ stereocontrol
Authors: Barbier‐Baudry Denise , Bouyer Frédéric , Madureira Bruno Ana Sofia , Visseaux Marc 
Published: October 2005

AbstractThis paper presents an extensive study of the polymerization of MMA with borohydrido lanthanide complexes for the first time. Catalytic systems are made from a lanthanide derivative bearing zero one, or two bulky ligands: substituted cyclopentadienyl (Cp*′ = C5Me4nPr, Cp4i = C5HiPr4, CpPh3 = H2C5Ph3‐1,2,4), and/or diketiminate ([(p‐tol)NN] = [(p‐CH3C6H4)N(CH3)C]2CH), in the presence of variable quantities of alkylating agent. With BuLi in apolar medium, highly isotactic polymer (up to 95.6%) is formed. In THF, syndiotactic‐rich PMMA is obtained whatever the nature of the co‐catalyst (BuLi or MgnBu2). The presence of an electron‐withdrawing ligand such as CpPh3 allows high syndioregularity, up to 81.8% at 0 °C, together with the highest conversion. There is quite good concordance between calculated and experimental molecular data in THF. Divalent Cp*′2SmII(THF) and (CpPh3)2SmII(THF) are active as single‐component initiators; the former affords PMMA 88% syndiotactic at 0 °C. Copyright © 2005 John Wiley & Sons, Ltd.
Structures and styrene polymerization activities of a series of nickel complexes bearing ligands of pyrazolone derivatives
Authors: Bao Feng , Ma Rui , Lü Xingqiang , Gui Guoqiu , Wu Qing 
Published: October 2005

AbstractA series of nickel complexes with β‐ketoamine ligands based on pyrazolone derivatives were synthesized by condensing pyrazolone with aniline, 2‐chloroaniline or naphthylamine and then reacting the produced β‐ketoamine with nickel halide. The solid‐state structures of these three complexes were determined by single‐crystal X‐ray diffraction. The bis(β‐ketoamine)nickel complexes are all air‐stable and can act as highly active catalyst precursors for styrene polymerization with activation of methylaluminoxane under mild reaction conditions. The activity of the catalyst for styrene polymerization is as high as 2.10 × 105 g polymer/mol Ni h. Both steric and electronic effects were found to be important and influential for catalytic activity. Copyright © 2005 John Wiley & Sons, Ltd.
Productivity in the Internet mailing lists: A bibliometric analysis
Authors: Kuperman Victor 
Published: October 2005

AbstractThe author examines patterns of productivity in the Internet mailing lists, also known as discussion lists or discussion groups. Datasets have been collected from electronic archives of two Internet mailing lists, the LINGUIST and the History of the English Language. Theoretical models widely used in informetric research have been applied to fit the distribution of posted messages over the population of authors. The Generalized Inverse Poisson‐Gaussian and Poisson‐lognormal distributions show excellent results in both datasets, while Lotka and Yule–Simon distribution demonstrate poor‐to‐mediocre fits. In the mailing list where moderation and quality control are enforced to a higher degree, i.e., the LINGUIST, Lotka, and Yule–Simon distributions perform better. The findings can be plausibly explained by the lesser applicability of the success‐breeds‐success model to the information production in the electronic communication media, such as Internet mailing lists, where selectivity of publications is marginal or nonexistent. The hypothesis is preliminary, and needs to be validated against the larger variety of datasets. Characteristics of the quality control, competitiveness, and the reward structure in Internet mailing lists as compared to professional scholarly journals are discussed.
The autoparametric 3:2 resonance in conservative systems
Authors: Horák J. 
Published: October 2005

AbstractIn the resonance model, high‐frequency quasi‐periodic oscillations (QPOs) are supposed to be a consequence of nonlinear resonance between modes of oscillations occurring within the innermost parts of an accretion disk. Several models with a prescribed mode–mode interaction were proposed in order to explain the characteristic properties of the resonance in QPO sources. In this paper, we examine nonlinear oscillations of a system having a quadratic nonlinearity and we show that this case is particularly relevant for QPOs. We present a very convenient way how to study autoparametric resonances of a fully general system using the method of multiple scales. We concentrate to conservative systems and discuss their behavior near the 3:2 parametric resonance. (© 2005 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Resonance conditions
Authors: Rebusco P. 
Published: October 2005

AbstractNon‐linear parametric resonances occur frequently in nature. Here we summarize how they can be studied by means of perturbative methods. We show in particular how resonances can affect the motion of a test particle orbiting in the vicinity of a compact object. These mathematical toy‐models .nd application in explaining the structure of the observed kHz Quasi‐Periodic Oscillations: we show which aspects of the reality naturally enter in the theory, and which one still remain a puzzle. (© 2005 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Forced oscillations in fluid tori and quasi‐periodic oscillations
Authors: Lee W. H. 
Published: October 2005

AbstractThe kilo‐Hertz Quasi‐Periodic Oscillations in X‐ray binaries could originate within the accretion flow, and be a signature of non–linear fluid oscillations and mode coupling in strong gravity. The possibility to decipher these systems will impact our knowledge of fundamental parameters such as the neutron star mass, radius, and spin. Thus they offer the possibility to constrain the nuclear equation of state and the rotation parameter of stellar–mass black holes. We review the general properties of these oscillations from a hydrodynamical point of view, when the accretion flow is subject to external perturbations and summarize recent results. (© 2005 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Global oscillations of a fluid torus as a modulation mechanism for black‐hole high‐frequency QPOs
Authors: Bursa M. 
Published: October 2005

AbstractWe study strong‐gravity effects on modulation of radiation emerging from accreting compact objects as a possible mechanism for flux modulation in QPOs. We construct a toy model of an oscillating torus in the slender approximation assuming thermal bremsstrahlung for the intrinsic emissivity of the medium and we compute observed (predicted) radiation signal including contribution of indirect (higher‐order) images and caustics in the Schwarzschild spacetime. We show that the simplest oscillation mode in an accretion flow, axisymmetric up‐and‐down motion at the meridional epicyclic frequency, may be directly observable when it occurs in the inner parts of accretion flow around black holes. Together with the second oscillation mode, an in‐and‐out motion at the radial epicyclic frequency, it may then be responsible for the high‐frequency modulations of the X‐ray flux observed at two distinct frequencies (twin HF‐QPOs) in micro‐quasars. (© 2005 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
The correlations and anticorrelations in QPO data
Authors: Abramowicz M. A. , Barret D. , Bursa M. , Horák J. , Kluźniak W. , Rebusco P. , Török G. 
Published: October 2005

AbstractDouble peak kHz QPO frequencies in neutron star sources varies in time by a factor of hundreds Hz while in microquasar sources the frequencies are fixed and located at the line ν 2 = 1.5ν 1 in the frequency‐frequency plot. The crucial question in the theory of twin HFQPOs is whether or not those observed in neutron‐star systems are essentially different from those observed in black holes. In black hole systems the twin HFQPOs are known to be in a 3:2 ratio for each source. At first sight, this seems not to be the case for neutron stars. For each individual neutron star, the upper and lower kHz QPO frequencies, ν 2 and ν 1, are linearly correlated, ν 2 = Aν 1 + B , with the slope A < 1.5, i.e., the frequencies definitely are not in a 1.5 ratio. In this contribution we show that when considered jointly on a frequency‐frequency plot, the data for the twin kHz QPO frequencies in several (as opposed to one) neutron stars uniquely pick out a certain preferred frequency ratio that is equal to 1.5 for the six sources examined so far. (© 2005 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
On the Influence of Charged Side Chains on the Folding–Unfolding Equilibrium of β‐Peptides: A Molecular Dynamics Simulation Study
Authors: Glättli Alice , Daura Xavier , Bindschädler Pascal , Jaun Bernhard , Mahajan Yogesh R. , Mathad Raveendra I. , Rueping Magnus , Seebach Dieter , van Gunsteren Wilfred F. 
Published: October 2005

AbstractThe influence of charged side chains on the folding–unfolding equilibrium of β‐peptides was investigated by means of molecular dynamics simulations. Four different peptides containing only negatively charged side chains, positively charged side chains, both types of charged side chains (with the ability to form stabilizing salt bridges) or no charged side chains were studied under various conditions (different simulation temperatures, starting structures and solvent environment). The NMR solution structure in methanol of one of the peptides (A) has already been published; the synthesis and NMR analysis of another peptide (B) is described here. The other peptides (C and D) studied herein have hitherto not been synthesized. All four peptides A–D are expected to adopt a left‐handed 314‐helix in solution as well as in the simulations. The resulting ensembles of structures were analyzed in terms of conformational space sampled by the peptides, folding behavior, structural properties such as hydrogen bonding, side chain–side chain and side chain–backbone interactions and in terms of the level of agreement with the NMR data available for two of the peptides. It was found that the presence of charged side chains significantly slows down the folding process in methanol solution due to the stabilization of intermediate conformers with side chain–backbone interactions. In water, where the solvent competes with the solute–solute polar interactions, the folding process to the 314‐helix is faster in the simulations.
Oligoethylene Chains Terminated by Ferrocenyl End Groups: Synthesis, Structural Properties, and Two‐Dimensional Self‐Assembly on Surfaces
Authors: Wedeking Katrin , Mu Zhongcheng , Kehr Gerald , Cano Sierra Jesus , Mück Lichtenfeld Christian , Grimme Stefan , Erker Gerhard , Fröhlich Roland , Chi Lifeng , Wang Wenchong , Zhong Dingyong , Fuchs Harald 
Published: October 2005

AbstractA series of unsaturated long‐chain‐bridged diferrocenes Fc‐(CH2)n‐CHCH‐(CH2)n‐Fc (4 a–e) was synthesized by means of olefin metathesis. Subsequent catalytic hydrogenation furnished the saturated α,ω‐bis‐ferrrocenyl oligoethylene products Fc‐(CH2)m‐Fc (5). Members of both series formed highly ordered laminar structures at the highly oriented pyrolytic graphite (HOPG) solid/liquid interface or on the Ag(110) surface, which were characterized by STM. Details of the structural features of these ordered physisorbed surface assemblies of 4 and 5 were analyzed by comparison with DFT calculations on model systems and with the characteristic packing modes of these systems in the crystal.
Photophysics of a Series of Efficient Fluorescent pH Probes for Dual‐Emission‐Wavelength Measurements in Aqueous Solutions
Authors: Charier Sandrine , Ruel Odile , Baudin Jean‐Bernard , Alcor Damien , Allemand Jean‐François , Meglio Adrien , Jullien Ludovic , Valeur Bernard 
Published: October 2005

AbstractThis paper evaluates the 5‐aryl‐2‐pyridyloxazole backbone to engineer donor–acceptor fluorescent pH probes after one‐ or two‐photon absorption. Parent fluorophores, as well as derivatives that can be used to label biomolecules, can be easily obtained in good yields. These molecules exhibit a large one‐photon absorption in the near‐UV range, and a strong fluorescence emission that covers the whole visible domain. The 5‐aryl‐2‐pyridyloxazole derivatives also possess significant cross sections for two‐photon absorption. Upon pyridine protonation, large shifts were observed in the absorption spectra after one‐ and two‐photon excitation, as well as in the emission spectra. This feature was used to measure the pKa of the investigated compounds that range between 2 and 8. In most of the investigated derivatives, the pKa increased upon light excitation and protonation exchanges took place during the lifetime of the excited state, as shown by phase‐modulation fluorometry analysis. Several 5‐aryl‐2‐pyridyloxazole derivatives are suggested as efficient probes to reliably measure the pH of aqueous solutions by means of ratiometric methods that are dependent on fluorescence emission.
Synthesis and Crystal Structures of Zirconium(IV) Nitrate Complexes (NO2) [Zr(NO3)3(H2O)3] 2(NO3)3 (I), Cs[Zr(NO3)5] (II), and (NH4)[Zr(NO3)5](HNO3) (III).
Authors: Morozov I. V. , Fedorova A. A. , Palamarchuk D. V. , Troyanov S. I. 
Published: October 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Photoelectrochemical Study of Lanthanide Titanium Oxides, Ln2Ti2O7 (Ln: La, Sm, and Gd).
Authors: Uno Masayoshi , Kosuga Atsuko , Okui Mihoko , Horisaka Kentarou , Yamanaka Shinsuke 
Published: October 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Solvolytic Routes to New Nonabismuth Hydroxy‐ and Alkoxy‐oxo Complexes: Synthesis, Characterization and Solid‐State Structures of Novel Nonabismuth Polyoxo Cations Bi9(μ3‐O)8 (μ3‐OR)65+ (R: H, Et).
Authors: Thurston John H. , Swenson Dale C. , Messerle Louis 
Published: October 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Low‐Dimensional Structural Units in Amine‐Templated Uranyl Oxoselenates(VI): Synthesis and Crystal Structures of [C3H12N2] [(UO2)(SeO4)2(H2O)2] (H2O) (I), [C5H16N2]2 [(UO2)(SeO4)2(H2O)] (NO3)2 (II), [C4H12N] [(UO2)(SeO4)(NO3)] (III), and [C4H14N2] [(UO2)(SeO4)2(H2O)] (IV).
Authors: Krivocochev Sergey V. , Kahlenberg Volker 
Published: October 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Highly Enantioselective Preparation of Tertiary Alcohols and Amines by Copper‐Mediated Diastereoselective Allylic SN2′ Substitutions.
Authors: Leuser Helena , Perrone Sylvie , Liron Frederic , Kneisel Florian F. , Knochel Paul 
Published: October 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
EtOH/Ba(OH)2 Triggers Self‐Condensation of (E)‐1,4‐Diaryl‐2‐butene‐1,4‐diones to Cyclopentanol Derivatives.
Authors: Rao H. Surya Prakash , Senthilkumar S. P. 
Published: October 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Stepwise Delivery of Two Methoxy Groups of Arylaldehyde Acetals Across the Phenyl Ring. Vacant Site‐Controlled Palladium Catalysis.
Authors: Nakamura Itaru , Mizushima Yuya , Gridnev Ilya D. , Yamamoto Yoshinori 
Published: October 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Microwave‐Assisted Intramolecular [2 + 2] Allenic Cycloaddition Reaction for the Rapid Assembly of Bicyclo[4.2.0]octa‐1,6‐dienes and Bicyclo[5.2.0]nona‐1,7‐dienes.
Authors: Brummond Kay M. , Chen Daitao 
Published: October 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Lactones. Part 17. Synthesis of Bicyclic Lactones with the Methyl‐ or gem‐Dimethylcyclopropane System.
Authors: Obara R. , Szumny A. , Zolnierczyk A. , Olejniczak T. , Bialonska A. , Ciunik Z. , Wawrzenczyk C. 
Published: October 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.