bluuebunny/crossref_metadata_2025_split huggingface dataset:
Update on Cancer Predisposition Syndromes and Surveillance Guidelines for Childhood Brain Tumors
Authors: Hansford Jordan R. , Das Anirban , McGee Rose B. , Nakano Yoshiko , Brzezinski Jack , Scollon Sarah R. , Rednam Surya P. , Schienda Jaclyn , Michaeli Orli , Kim Sun Young , Greer Mary-Louise C. , Weksberg Rosanna , Stewart Douglas R. , Foulkes William D. , Tabori Uri , Pajtler Kristian W. , Pfister Stefan M. , Brodeur Garrett M. , Kamihara Junne 
Published: April 2024

Abstract
Tumors of the central nervous system (CNS) comprise the second most common group of neoplasms in childhood. The incidence of germline predisposition among children with brain tumors continues to grow as our knowledge on disease etiology increases. Some children with brain tumors may present with nonmalignant phenotypic features of specific syndromes (e.g., nevoid basal cell carcinoma syndrome, neurofibromatosis type 1 and type 2, DICER1 syndrome, and constitutional mismatch-repair deficiency), while others may present with a strong family history of cancer (e.g., Li–Fraumeni syndrome) or with a rare tumor commonly found in the context of germline predisposition (e.g., rhabdoid tumor predisposition syndrome). Approximately 50% of patients with a brain tumor may be the first in a family identified to have a predisposition. The past decade has witnessed a rapid expansion in our molecular understanding of CNS tumors. A significant proportion of CNS tumors are now well characterized and known to harbor specific genetic changes that can be found in the germline. Additional novel predisposition syndromes are also being described. Identification of these germline syndromes in individual patients has not only enabled cascade testing of family members and early tumor surveillance but also increasingly affected cancer management in those patients. Therefore, the AACR Cancer Predisposition Working Group chose to highlight these advances in CNS tumor predisposition and summarize and/or generate surveillance recommendations for established and more recently emerging pediatric brain tumor predisposition syndromes.
Comprehensive Genomic Profiling Alters Clinical Diagnoses in a Significant Fraction of Tumors Suspicious of Sarcoma
Authors: Öfverholm Ingegerd , Wallander Karin , Haglund Cecilia , Chellappa Venkatesh , Wejde Johan , Gellerbring Anna , Wirta Valtteri , Renevey Annick , Caceres Eva , Tsagkozis Panagiotis , Mayrhofer Markus , Papakonstantinou Andri , Linder-Stragliotto Christina , Bränström Robert , Larsson Olle , Lindberg Johan , Lin Yingbo , Haglund de Flon Felix 
Published: April 2024

Abstract

Purpose:
Tumor classification is a key component in personalized cancer care. For soft-tissue and bone tumors, this classification is currently based primarily on morphology assessment and IHC staining. However, these standard-of-care methods can pose challenges for pathologists. We therefore assessed how whole-genome and whole-transcriptome sequencing (WGTS) impacted tumor classification and clinical management when interpreted together with histomorphology.

Experimental Design:
We prospectively evaluated WGTS in routine diagnostics of 200 soft-tissue and bone tumors suspicious for malignancy, including DNA and RNA isolation from the tumor, and DNA isolation from a peripheral blood sample or any non-tumor tissue.

Results:
On the basis of specific genomic alterations or absence of presumed findings, WGTS resulted in reclassification of 7% (13/197) of the histopathologic diagnoses. Four cases were downgraded from low-grade sarcomas to benign lesions, and two cases were reclassified as metastatic malignant melanomas. Fusion genes associated with specific tumor entities were found in 30 samples. For malignant soft-tissue and bone tumors, we identified treatment relevant variants in 15% of cases. Germline pathogenic variants associated with a hereditary cancer syndrome were found in 22 participants (11%).

Conclusions:
WGTS provides an important dimension of data that aids in the classification of soft-tissue and bone tumors, correcting a significant fraction of clinical diagnoses, and identifies molecular targets relevant for precision medicine. However, genetic findings need to be evaluated in their morphopathologic context, just as germline findings need to be evaluated in the context of patient phenotype and family history.
Electrical signal interference minimization using appropriate core material for 3D integrate circuit at high frequency applications
Authors: Kumar Malagonda Siva , Mohanraj Jayavelu 
Published: April 2024

As demand for smaller, quicker, and more powerful devices rises, Moore's law is strictly followed. The industry has worked hard to make little devices that boost productivity. The goal is to optimize device density. Scientists are reducing connection delays to improve circuit performance. This helped them understand three-dimensional integrated circuit (3D IC) concepts, which stack active devices and create vertical connections to diminish latency and lower interconnects. Electrical involvement is a big worry with 3D integrates circuits. Researchers have developed and tested through silicon via (TSV) and substrates to decrease electrical wave involvement. This study illustrates a novel noise coupling reduction method using several electrical involvement models. A 22% drop in electrical involvement from wave-carrying to victim TSVs introduces this new paradigm and improves system performance even at higher THz frequencies.
Thrombectomy in Patients With Ischemic Stroke Without Salvageable Tissue on CT Perfusion
Authors: Broocks Gabriel , McDonough Rosalie V. , Bechstein Matthias , Klapproth Susan , Faizy Tobias D. , Schön Gerhard , Kniep Helge C. , Bester Maxim , Hanning Uta , Kemmling André , Zeleñák Kamil , Fiehler Jens , Meyer Lukas 
Published: April 2024

BACKGROUND:
Computed tomography perfusion (CTP) imaging is regularly used to guide patient selection for mechanical thrombectomy (MT). However, the effect of MT in patients without salvageable tissue on CTP has not been investigated. The purpose of this study was to assess the effect of MT in patients with stroke without perfusion mismatch profiles.

METHODS:
This observational study analyzed patients with ischemic stroke consecutively treated between March 1, 2015, and January 31, 2022, triaged by multimodal-computed tomography undergoing MT. CTP lesion-core mismatch profiles were defined using a mismatch volume/ratio of ≥10 mL/1.2, respectively. The primary end point was the rate of functional independence at 90 days, defined as the modified Rankin Scale score of 0 to 2. Recanalization was evaluated with the modified Thrombolysis in Cerebral Infarction scale. The effect of baseline variables on functional outcome was assessed using multivariable logistic regression analysis. Outcomes of patients with and without CTP-mismatch profiles were compared using 1:1 propensity score matching.

RESULTS:

Of 724 patients who met the inclusion criteria of this retrospective observational study, 110 (15%) patients had no CTP mismatch and were analyzed. The median age was 74 (interquartile range, 62–80) years and 53% were women. Successful recanalization (modified Thrombolysis in Cerebral Infarction score, ≥2b) was achieved in 66% (73) and associated with functional independence at 90 days (adjusted odds ratio, 7.33 [95% CI, 1.22–43.70];
P
=0.03). A significant interaction was observed between recanalization and age, as well as the extent of infarction, indicating MT to be most effective in patients <70 years and with a baseline Alberta Stroke Program Early Computed Tomography Score range between 3 and 7. These findings remained stable after propensity score matching, analyzing 152 matched pairs with similar rates of functional independence between patients with and without CTP-mismatch profiles (17% versus 23%;
P
=0.42).

CONCLUSIONS:
In patients without CTP-mismatch profiles defined according to the EXTEND (Extending the Time for Thrombolysis in Emergency Neurological Deficits) criteria, recanalization was associated with improved functional outcomes. This effect was associated with baseline Alberta Stroke Program Early Computed Tomography Score and age, but not with the time from onset to imaging.
Genetically Determined Plasma Hepatocyte Growth Factor Levels Are Associated With the Risk and Prognosis of Ischemic Stroke
Authors: Xu Qingyun , Guo Daoxia , Shi Mengyao , Wang Yinan , Yang Pinni , Jia Yiming , Sun Lulu , Liu Yi , Chang Xinyue , He Yu , Hui Li , Zhang Yonghong , Zhu Zhengbao 
Published: April 2024

BACKGROUND:
Observational studies suggest that hepatocyte growth factor (HGF) is associated with the risk and prognosis of ischemic stroke, but the causality of these associations remains unclear. Therefore, we conducted Mendelian randomization (MR) analyses to explore the associations of genetically determined plasma HGF levels with the risk and prognosis of ischemic stroke.

METHODS:
A total of 13 single-nucleotide polymorphisms associated with plasma HGF were selected as genetic instruments based on the data from a genome-wide association study with 21 758 European participants. Summary data about the risk of ischemic stroke were obtained from the MEGASTROKE (Multiancestry Genome-Wide Association Study of Stroke) Consortium with 34 217 ischemic stroke cases and 406 111 controls of European ancestry, and summary data about the prognosis of ischemic stroke were obtained from the GISCOME study (Genetics of Ischaemic Stroke Functional Outcome) with 6165 European patients with ischemic stroke. We conducted an inverse-variance weighted Mendelian randomization analysis followed by a series of sensitivity analyses to evaluate the associations of genetically determined plasma HGF with the risk and prognosis of ischemic stroke.

RESULTS:

The primary analyses showed that genetically determined high HGF was associated with an increased risk of ischemic stroke (odds ratio per SD increase, 1.11 [95% CI, 1.04–1.19];
P
=1.10×10
−3
) and poor prognosis of ischemic stroke (odds ratio per SD increase, 2.43 [95% CI, 1.76–3.52];
P
=6.35×10
−8
). In the secondary analysis, genetically determined plasma HGF was associated with a high risk of large atherosclerotic stroke (odds ratio per SD increase, 1.39 [95% CI, 1.18–1.63];
P
=5.08×10
−5
) but not small vessel stroke and cardioembolic stroke. Mendelian randomization-Egger regression showed no directional pleiotropy for all associations, and the sensitivity analyses with different Mendelian randomization methods further confirmed these findings.

CONCLUSIONS:
We found positive associations of genetically determined plasma HGF with the risk and prognosis of ischemic stroke, suggesting that HGF might be implicated in the occurrence and development of ischemic stroke.
Catullus 32: Fututiones with Ipsitilla
Authors: Ferriss-Hill Jennifer 
Published: April 2024

Abstract
Catullus poem 32 has traditionally been read as describing an afternoon assignation with a prostitute. The reinterpretation offered here reads the poem not as a one-off piece about a figure mentioned nowhere else in Catullus, but rather as a poem that connects with those in the Lesbia-cycle as well as with Catullus’ metapoetic project more broadly. Ipsitilla, I argue, acts as a Muse-like figure analogous to Lesbia, and the fututiones she prepares for Catullus at his request represent his neoteric poetry: erotic, clever, and about the process of writing.
Taking Texts Seriously
Authors: Godzimirska Zuzanna , Kjaer Anne Lise 
Published: April 2024

Abstract
Many international law scholars have found inspiration in quantitative methods of text analysis in recent years. Such methods enable scholars to identify patterns in large quantities of text and challenge pre-existing assumptions about various aspects of international law, how it is developed, practiced, interpreted and applied. Yet, subjecting legal texts to quantitative methods of analysis also comes with notable shortcomings. When treating texts as abstract data in accordance with the logic of data science, researchers often fail to appreciate texts as means of human interaction and communication, thereby diverting attention from terms and meaning to numbers and statistics. The aim of this article is threefold: to offer a lay of the land of the burgeoning empirical legal scholarship that adopts text analytical approaches in its study of international law, exhibit what gets lost when insights from linguistics are ignored, and demonstrate what is gained when they are not.
The Blind Men and the Elephant
Authors: Steininger Silvia , Hamilton Byrne William , Oidtmann Raphael 
Published: April 2024

Abstract
What is the role of the social sciences in international law? This article maps how international law interacts with the social sciences, including its concepts, findings, methods, and epistemologies. It provides a first encompassing genealogy of social science references in six renowned international law journals, including the American, Asian, European, Leiden, and Nordic Journal of International Law as well as the British International and Comparative Law Quarterly, by using a corpus linguistic approach that encompasses more than 15,000 documents from 1907 to 2022. Moreover, it explores how structural factors related to the institutionalization and funding of certain strands of social science-inspired international law scholarship have influenced regional and temporal patterns in Europe, Germany, and Australia.
The Ethics of Inter-disciplinarity and the Academic Industry
Authors: Klabbers Jan 
Published: April 2024

Abstract
This contribution discusses the way the academic international law industry is organized and the impact this has on scholarship, which is often expected to be inter-disciplinary, with all the pitfalls this entails. These include ethical challenges, with the contribution offering a response to some of these. In the process, it briefly sketches the Nordic academic landscape.
Gender and the Performance of Death Rituals in Classical Athens 480–332 BCE
Authors: Salem Radwa 
Published: April 2024

Abstract
Death rituals play a significant role in maintaining the cultural system of different societies by providing a specific form of behaviour in response to death. To that end, the significant role of women as patrons of culture can be identified by studying their role in the performance of death rituals. Classical Athens provides a good case study as women performed most phases of the mortuary treatment, and their role is recognised in both the textual and material evidence. This gives us the opportunity to diverge from the ‘typical male perspective’-approach to the mortuary evidence, which focuses on the socio-political and economic dimensions, and shed light on the agency of women. The female agency was responsible for the continuity of some ancient rituals despite the laws made to restrict them. Moreover, relatively wealthier women were indirect agents influencing the Athenian public life by using excessive death rituals to reallocate power in society after the loss of powerful individuals.
The Ghadar Movement in Thailand, 1914–1917: Overseas Indian ‘Rebels’ and Their Multinational Asian Assistants
Authors: Wibulsilp Pimmanus 
Published: April 2024

Abstract
The Ghadar Movement was an effort by a group of overseas Indians from diverse diasporas around the Indo-Pacific region to set up an armed revolution to free India from the grip of British colonialism. This work mainly argues that Thailand was not merely functioning as a passage of the Ghadarites from abroad to return to India through its borders, but instead that different parts of the country were harboring their various clandestine and seditious missions. These activities were not only carried out by the overseas Indians travelling from abroad, but also by many “local Indians” in Thailand who turned themselves into active underground revolutionaries. By analyzing several cases of multinational Asian “allies” of the Ghadarites in Thailand, this study furthers the discussion initiated by previous scholars on the possible links between the Ghadar Movement and the tide of “Pan-Asianism” flourishing in different parts of Asia during the early twentieth century.
Liberating Thai History: The Thai Past in an Asian Century
Authors: Subrahmanyan Arjun 
Published: April 2024

Abstract
The nationalist plot of modern Thai history stresses the kingdom’s exceptionalism as the only un-colonized state in Southeast Asia and highlights the steadiness of unbroken monarchy. Critics of the established narrative by contrast argue that Siam/Thailand bore many similarities to neighboring satellites of the Western powers that subordinated traditional authority and hence was a “semi-colony” of the West rather than a truly independent state. This paper argues that the semi-colonial view remains a better frame to study modern Thai history and that semi-coloniality produced a hybrid political culture among an educated new generation born around 1900. The young generation forged the popular struggles that after the 1932 end of the absolute monarchy sought to build a more fair and equitable society. These aspirations and the hybrid political culture of the time are a crucial but often overlooked part of modern Thai history.
A Comparison of Channel Selection for the Assimilation of CrIS Radiances for NWP
Authors: Coursol Laurence , Heilliette Sylvain , Gauthier Pierre 
Published: April 2024

Abstract
With hyperspectral instruments measuring radiation emitted by Earth and its atmosphere in the thermal infrared range in multiple channels, several studies were made to select a subset of channels in order to reduce the number of channels to be used in a data assimilation system. An optimal selection of channels based on the information content depends on several factors related to observation and background error statistics and the assimilation system itself. An optimal channel selection for the Cross-track Infrared Sounder (CrIS) was obtained and then compared to selections made for different NWP systems. For instance, the channel selection of Carminati has 224 channels also present in our optimal selection, which includes 455 channels. However, in terms of analysis error variance, the difference between the two selections is small. Integrated over the whole profile, the relative difference is equal to 15.3% and 4.5% for temperature and humidity, respectively. Also, different observation error covariance matrices were considered to evaluate the impact of this matrix on channel selection. Even though the channels selected optimally were different in terms of which channels were selected for the various matrices, the results in terms of analysis error are similar.

Significance Statement
Satellites measure radiation from Earth and its atmosphere in the thermal infrared. Those radiance data contain thousands of measurements, called channels, and thus, a selection needs to be done retaining most of the information content since the large number of individual pieces of information is not usable for numerical weather prediction systems. The goal of this paper is to find an optimal selection for the instrument CrIS and to compare this selection with selections made for different numerical weather prediction systems. It was found that even though the channels selected optimally were different in terms of which channels were selected compared to other selections, the results in terms of precision of the analysis are similar and the results in terms of analysis error are similar due to the nature of hyperspectral instruments, which have multiple Jacobians overlapping.
Depression, anxiety, hopelessness, and suicide in first-degree relatives of patients hospitalized in intensive care units in Turkey
Authors: Yanmaz Başak Merve , Yüce Aktepe Melike , Erdoğan Ali , Çakin Özlem 
Published: April 2024

Objective The purpose of this study was to investigate the prevalence of depression, anxiety disorder, hopelessness, and suicide among first-degree relatives of patients hospitalized in medical and anesthesia intensive care units at an academic medical centre. Methods In this case–control study conducted in Türkiye, 32 first-degree relatives of 32 patients hospitalized for 14 days or more in intensive care units and 32 healthy volunteers were assessed. The Beck Depression Scale (BDS), Beck Anxiety Scale (BAS), Beck Hopelessness Scale (BHS), and Suicide Probability Scale (SPS) were administered to participants. Results The mean age of patients’ relatives was 42.1 ± 11.6 years and that of the controls was 43.0 ± 11.3 years. The median scores for the BDS, BHS, and SPS were significantly higher among the relatives of the patients than among controls ( P = .008, P = .013, and P = .001, respectively). Based on cutoff scores for the BDS and BAS, significant depressive symptoms were observed in 56.3% of the relatives of the patients and significant anxiety symptoms were observed in 46.9%. Among patients’ relatives, the median score for the BDS was significantly higher among female participants than among male participants ( P = .038). Conclusions First-degree relatives of patients hospitalized in intensive care units have a higher prevalence of depression, hopelessness, and suicidality. Female relatives scored higher on depressive symptoms than male relatives. Psychiatric evaluation/screening of the relatives of patients hospitalized in intensive care units in Turkey is essential.
Thermo-mechanical characterizations and erosion wear studies of fumed silica-reinforced jute/epoxy composites
Authors: Parida Pramod Kumar , Alam Mohammad Irquam , Ghosh Ritwik , Pradhan Arun Kumar , Pandit Mihir Kumar , Maharana Sunil Manohar 
Published: April 2024

This study investigates the influence of nano-fumed silica content on thermo-mechanical properties of jute/epoxy composites. The results reveal that jute composites without filler (JJJJ-0) exhibited highest tensile strength (33.01 MPa) and percentage elongation (1.9522%), while composites with 1.5% and 2.5% filler demonstrated the highest tensile modulus (1967 MPa) and flexural modulus (2432.9 MPa), respectively. The observation demonstrates that as the filler content increases in jute composites, tensile strength decreases but flexural strength increases. However, an exception is noted for sample containing excess filler (3.5%), which exhibited the lowest flexural strength (44.36 MPa). The composite with 2.5% filler exhibited the highest flexural strength (53.5 MPa). Thermal analysis indicated that the addition of nanofiller enhanced both the activation energy (Ea) and thermal stability of the jute composites. A four-layer carbon composite without filler (CCCC-0) was also fabricated in order to compare wear and thermal stability performance with jute composites. The wear study was performed at different temperatures and found that JJJJ-3.5 composite exhibited superior wear resistance at ambient temperature, while CCCC-0 composite had better wear resistance at high temperatures. Also, the surface morphology of the eroded surface was examined using a scanning electron microscope (SEM) to study the failure mechanism of composites.