bluuebunny/crossref_metadata_2025_split huggingface dataset:
Medication-Overuse Headache
Authors: Rizzoli Paul 
Published: April 2024

ABSTRACT

Objective
Medication-overuse headache (MOH) has been described for almost 100 years and is characterized as a daily or near-daily headache that usually presents in patients with preexisting primary headache disorders who are overusing one or more acute or symptomatic headache medications. This article reviews the diagnosis and management of patients with MOH.

Latest Developments
The International Classification of Headache Disorders criteria for MOH have changed over time. The worldwide prevalence appears to be between 1% and 2%. Together, headache disorders, including MOH, are currently ranked as the second leading cause of years lived with disability in the Global Burden of Disease world health survey. Significant neurophysiologic changes are seen in the brains of patients with MOH, including functional alterations in central pain processing and modulating systems and central sensitization. Research supports updates to the principles of management, including weaning off the overused medication, preventive therapy, biobehavioral therapy, and patient education.

Essential Points
MOH is a fairly common and treatable secondary headache disorder that produces significant disability and a substantial reduction in quality of life. The costs related to lost income and disability are substantial. MOH is intimately related to chronic migraine, which continues to be underrecognized and undertreated. Treatment focuses on both the institution of effective preventive migraine therapy and the reduction or removal of the overused medications. Educational efforts directed toward both providers and patients have been shown to be effective in reducing the effect of MOH.
Pathophysiology of Migraine
Authors: Karsan Nazia 
Published: April 2024

ABSTRACT

Objective
This article provides an overview of the current understanding of migraine pathophysiology through insights gained from the extended symptom spectrum of migraine, neuroanatomy, migraine neurochemistry, and therapeutics.

Latest Developments
Recent advances in human migraine research, including human experimental migraine models and functional neuroimaging, have provided novel insights into migraine attack initiation, neurochemistry, neuroanatomy, and therapeutic substrates. It has become clear that migraine is a neural disorder, in which a wide range of brain areas and neurochemical systems are implicated, producing a heterogeneous clinical phenotype. Many of these neural pathways are monoaminergic and peptidergic, such as those involving calcitonin gene-related peptide and pituitary adenylate cyclase-activating polypeptide. We are currently witnessing an exciting era in which specific drugs targeting these pathways have shown promise in treating migraine, including some studies suggesting efficacy before headache has even started.

Essential Points
Migraine is a brain disorder involving both headache and altered sensory, limbic, and homeostatic processing. A complex interplay between neurotransmitter systems, physiologic systems, and pain processing likely occurs. Targeting various therapeutic substrates within these networks provides an exciting avenue for future migraine therapeutics.
Preventive Treatment of Migraine
Authors: Lipton Richard B. 
Published: April 2024

ABSTRACT

OBJECTIVE
This article describes strategies for the preventive treatment of migraine including the emerging role of calcitonin gene-related peptide (CGRP)-targeted therapies and introduces novel paradigms for the preventive treatment of migraine.

LATEST DEVELOPMENTS
Multiple migraine medications targeting CGRP have been introduced since 2018, including injectable monoclonal antibodies (ie, eptinezumab, erenumab, fremanezumab, and galcanezumab) and oral small-molecule CGRP receptor antagonists (ie, ubrogepant, rimegepant, atogepant, and zavegepant). With the exceptions of ubrogepant and zavegepant, which are approved only as acute treatments, all of these agents have demonstrated efficacy in the preventive treatment of migraine; the monoclonal antibodies and atogepant have evidence of effectiveness in adults with either episodic or chronic migraine. The safety and tolerability profiles of CGRP-targeted therapies in migraine are favorable.

ESSENTIAL POINTS
The goals of preventive migraine therapy include reducing the frequency, severity, duration, and disability associated with attacks, reducing the need for acute treatment and the risk of medication overuse, enhancing self-efficacy and health-related quality of life, and reducing headache-related distress and interictal burden. Six drugs targeting CGRP (four monoclonal antibodies and two gepants) are now available for the preventive treatment of episodic migraine in adults. The efficacy of CGRP-targeted medications in the acute and preventive treatment of migraine, together with good safety and tolerability, has led to the emergence of new approaches to preventive treatment.
Solidarity as a Political Determinant of Health: Insights from EU Competition Policy
Authors: Guy Mary 
Published: April 2024

Abstract
Context: The connection between law and political determinants of health is not well understood, but nevertheless it is suggested that the two are inseparable, and this represents an upstream level with scope for influencing other determinants of health (particularly social determinants). Solidarity underpins European health care systems, and given its clear link with redistribution, it can be seen as a means for addressing health inequities. As such, solidarity may be seen as a political determinant of health in the specific context of European Union (EU) competition policy.
Methods: A range of EU case law, treaty provisions, and European Commission publications relating to EU competition policy are analyzed.
Findings: Solidarity is typically juxtaposed as antithetical to competition and thus as underpinning exceptions to the applicability of prohibitions on anticompetitive agreements, abuse of dominance, and state aid. Case law indicates an additional dynamic between definitions of solidarity at the EU and national levels.
Conclusions: This analysis leads to two groups of considerations when framing solidarity as a political determinant of health in the EU competition policy context: first, the predominance of solidarity suggests it may shape competition reforms; second, the EU–member state dynamic indicates less EU-level reach into national competition reforms in health care than may be expected.
Visual perception of facial expressions of emotions and alexithymia among people suffering from schizophrenia
Authors: Subocz Dawid 
Published: April 2024

Aim of the studyThe aim of the study is to find out whether there is a relationship between the severity of alexithymia and the visual perception of facial expressions of emotions among people suffering from schizophrenia.Subject or material and methods41 people suffering from schizophrenia and 41 healthy people participated in the study. In the first stage, the subjects completed the Toronto Alexithymia Scale (TAS-20) questionnaire. The second stage was based on eye-tracking measurements made during a computer experiment of recognising facial expressions.ResultsPeople with schizophrenia showed significantly higher intensity of alexithymia than healthy people. In the group of patients with schizophrenia, a negative correlation between alexithymia and the length of saccades on the nose was found.DiscussionIn the group of people with schizophrenia, alexithymia is associated with less intensive exploration of the nasal area. A wrinkled nose is an important area, first of all, in the manifestation of negative emotions, in recognition of which the sick people make the most mistakes.ConclusionsProblems with recognising emotions in people suffering from schizophrenia are associated with neuronal dysfunction and abnormalities in the eye movement. These factors disrupt the early stages of sensory processing. The relationship of alexithymia with the visual perception of patients with schizophrenia suggests that top-down processes may also contribute to the development of these deficits.
Developing scale of attitudes toward internet psychological support
Authors: Chęć Magdalena , Ligocka Maria , Konieczny Krystian , Czerwińska Paulina , Tyburski Ernest , Rachubińska Karolina , Michałowska Sylwia 
Published: April 2024

Aim of the studyThe interest in remote psychological services is currently increasing. Changing the way psychological help is provided requires considering new issues, including patients’ attitudes toward this form of help. The aim of the study was to construct and determine the psychometric properties of a tool for assessing attitudes toward psychological help provided via the Internet among healthy and clinical group.Subject or material and methods154 items were selected from the original pool of 330 items. A pilot study was carried out on a group of 100 students (60% females, MAge = 23.3). The final version of the tool included 43 items whose discriminant power is higher than 0.5. Cronbach’s α for the final version of the tool was .975. 10 scales were distinguished and a reliability test (α = .966) was carried out on 100 healthy people.ResultsAs a result of a factor analysis performed on the data obtained from a study of healthy people (N = 100; 74% females; MAge = 29.5) and clinical group (N = 466; 54% females; MAge = 40.6), a final three-factor structure of the tool with appropriate reliability and differential validity was obtained.DiscussionThe final version of the SPWPPO-2 questionnaire consists of 43 items. A tool that meets the criteria of psychometric goodness was obtained. It can be used in research on general and clinical populations and also in practice.ConclusionsThe tool is useful in research and clinical areas. It can be used by mental health professionals to assess attitudes toward online psychological support for patients and potential patients.
Deferred Tax Asset Revaluations, Costly Information Processing, and Bank Deposits: Evidence from the Tax Cuts and Jobs Act
Authors: Mohrmann Ulf , Riepe Jan 
Published: April 2024

We examine how information processing costs affect the extent to which depositors’ use the details in banks’ income statements. Depositors have a unique cost-benefit structure because they are nonprofessional users of financial information and have high information processing costs. At the same time, they benefit from acting quickly because failing banks make payments on a first-come, first-serve basis. This makes it likely that they will react to a prominent summary measure like the reported net income without adjusting for any risk-irrelevant information included in the line items. In our empirical analysis, we investigate depositors’ behavior as driven by the mechanical revaluations of deferred tax assets due to the 2017 Tax Cuts and Jobs Act. Using a difference-in-difference design, we find deposit withdrawals because of this risk-irrelevant information. In cross-sectional tests, we show that the withdrawals are stronger if the information acquisition costs are low, and the information integration costs are high. Overall, our results show that information processing costs are important for understanding depositors’ reactions to accounting information and can lead to deposit flows that cannot be explained by new risk-relevant information. This paper was accepted by Brian Bushee, accounting. Funding: We kindly acknowledge funding by the Werner Diez Foundation [Grant 2024.1] to make this work available under a Creative Commons license. Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2022.03176 .
Late tuberculosis reactivation after severe COVID-19
Authors: Dormans Tom , Zandijk Eric , Stals Frans 
Published: April 2024

Background: Although there is no specific therapy for COVID-19, it is recommended that patients with severe SARS-CoV-2 infection are treated with corticosteroids and anti-IL-6 receptor monoclonal antibodies. Both COVID-19 itself and the treatment modalities mentioned above have suppressive effects on the immune system which may lead to an increased susceptibility to other infections. In patients with latent tuberculosis (TB) reactivation of TB infection after recovery from severe COVID-19 has been described. Most of these cases have occurred in parts of the world where tuberculosis is endemic. Case description: The patient is a female in her 70s who was born and raised in Southeast Asia and has lived in the Netherlands for more than 30 years. She was treated for a severe COVID-19 requiring mechanical ventilation for several weeks and pharmaceutical treatment with corticosteroids and anti-IL-6 receptor monoclonal antibodies (Sarilumab). She recovered well. Two years later she was readmitted with symptoms of a serious pulmonary infection and meningitis. Her condition deteriorated in a short time. An active TB infection was diagnosed. Despite adequate antibiotic treatment and supportive therapy her condition worsened and four days after admission to the ICU she deceased. Discussion: Reactivation of latent TB after recovery from a severe COVID-19 has been described several times and may occur several months after the SARS-CoV-2 infection. In this case the reactivation presented two years after COVID-19. This case illustrates that long-term follow-up of patients with latent TB that recover from a severe COVID-19 may be indicated.
Causality of genetically determined blood metabolites on irritable bowel syndrome: A Mendelian randomization study
Authors: Dai Xinyi , Liang Min , Dai Yanna , Ding Shaohua , Sun Xiaohe , Xu Luzhou 
Published: April 2024

Background
Irritable bowel syndrome (IBS) is one of the most common functional bowel disorders and dysmetabolism plays an important role in the pathogenesis of disease. Nevertheless, there remains a lack of information regarding the causal relationship between circulating metabolites and IBS. A two-sample Mendelian randomization (MR) analysis was conducted in order to evaluate the causal relationship between genetically proxied 486 blood metabolites and IBS.

Methods
A two-sample MR analysis was implemented to assess the causality of blood metabolites on IBS. The study utilized a genome-wide association study (GWAS) to examine 486 metabolites as the exposure variable while employing a GWAS study with 486,601 individuals of European descent as the outcome variable. The inverse-variance weighted (IVW) method was used to estimate the causal relationship of metabolites on IBS, while several methods were performed to eliminate the pleiotropy and heterogeneity. Another GWAS data was used for replication and meta-analysis. In addition, reverse MR and linkage disequilibrium score regression (LDSC) were employed for additional assessment. Multivariable MR analysis was conducted in order to evaluate the direct impact of metabolites on IBS.

Results
Three known and two unknown metabolites were identified as being associated with the development of IBS. Higher levels of butyryl carnitine (OR(95%CI):1.10(1.02–1.18),p = 0.009) and tetradecanedioate (OR(95%CI):1.13(1.04–1.23),p = 0.003)increased susceptibility of IBS and higher levels of stearate(18:0)(OR(95%CI):0.72(0.58–0.89),p = 0.003) decreased susceptibility of IBS.

Conclusion
The metabolites implicated in the pathogenesis of IBS possess potential as biomarkers and hold promise for elucidating the underlying biological mechanisms of this condition.
High-Flow Nasal Cannula Oxygen Therapy versus Non-Invasive Ventilation in patients at very high risk for extubating failure: A systematic review of randomized controlled trials
Authors: Al Nufaiei Ziyad F. , Al Zhranei Raid M. 
Published: April 2024

Background
Mechanical ventilation is commonly used for managing respiratory failure in chronic obstructive pulmonary disease (COPD) patients, but weaning patients off ventilator support can be challenging and associated with complications. While many patients respond well to Non-invasive ventilation (NIV), a significant proportion may not respond as favourably. We aimed to assess whether high-flow nasal cannula (HFNC) is equally effective as NIV in reducing extubation failure among previously intubated COPD patients.

Methods
This systematic review was carried out in line with PRISMA guidelines We searched PubMed, Scopus, Web of Science, and Cochrane library from inception until February 15, 2023. Randomized Clinical Trials (RCTs) of adults at high risk for extubating failure were included. We examined the use of HFNC as the intervention and NIV as the comparator. Our outcome of interest included, reintubation rate, length of hospital or intensive care unit (ICU) stay, adverse events, and time to reintubation. The Cochrane risk-of-bias tool was used for randomized trials to assess risk of bias.

Results
We identified 348 citations, 11 of which were included, representing 2,666 patients. The trials indicate that HFNC is comparable to NIV in preventing reintubation after extubating in COPD patients. In comparison to NIV, HFNC also produced improved tolerance, comfort, and less complications such as airway care interventions. NIV with active humification may be more effective that HFNC in avoiding reintubation in patients who are at extremely high risk for extubating failure.

Conclusion
The inconclusive nature of emerging evidence highlights the need for additional studies to establish the efficacy and suitability of HFNC as an alternative to NIV for previously intubated COPD patients. Clinicians should consider the available options and individualize their approach based on patient characteristics. Future research should focus on addressing these gaps in knowledge to guide clinical decision-making and optimize outcomes for this patient population.
Decreased odds of depressive symptoms and suicidal ideation with higher education, depending on sex and employment status
Authors: Tassone Vanessa K. , Duffy Sophie F. , Dunnett Sarah , Boparai Josheil K. , Zuluaga Cuartas Valentina , Jung Hyejung , Wu Michelle , Goel Navya , Lou Wendy , Bhat Venkat 
Published: April 2024

BackgroundHigher education is associated with reduced depressive symptoms and requires investment without guaranteed employment. It remains unclear how sex and employment status together contribute to the association between mental health and educational attainment. This study investigated the role of sex and employment status together in the associations of 1) depressive symptoms and 2) suicidal ideation with education.MethodsUsing 2005–2018 National Health and Nutrition Examination Survey data, cross-sectional analyses were conducted on individuals ≥20 years who completed the depression questionnaire and reported their employment status and highest level of education. Survey-weighted multivariable logistic regression models were used to explore how depressive symptoms and suicidal ideation are associated with educational attainment in an analysis stratified by sex and employment status. To account for multiple testing, a significance level ofa< 0.01 was used.ResultsParticipants (n= 23,669) had a weighted mean age of 43.25 (SD= 13.97) years and 47% were female. Employed females (aOR = 0.47, 95% CI 0.32, 0.69), unemployed females (aOR = 0.47, 95% CI 0.29, 0.75), and unemployed males (aOR = 0.31, 95% CI 0.17, 0.56) with college education had reduced odds of depressive symptoms compared to those with high school education. Employed females with college education also had reduced suicidal ideation odds compared to those with high school education (aOR = 0.41, 95% CI 0.22, 0.76).ConclusionsFemales demonstrated significant associations between depressive symptoms and education, regardless of employment status, whereas males demonstrated an association only if unemployed. Employed females, in particular, demonstrated a significant association between suicidal ideation and education. These findings may inform future research investigating the underlying mechanisms and etiology of these sex-employment status differences in the association between mental health and education.
Association between hemoglobin trajectories and the incidence of dementia in a cohort of females aged 55–79 years
Authors: Lee Dong Yoon , Jeong Jihyeon , Choi Won-Il 
Published: April 2024

Purpose
To assess the association between pattern changes in hemoglobin levels over time and the incidence of dementia using trajectories in females aged 55–79 years.

Materials and methods
We conducted a retrospective cohort study using females of aged 55–79 years from the National Health Insurance Service National Health Screening Cohort in Korea. To identify hemoglobin trajectories over eight years (2002–2009), we performed a three-step approach comprising measures of change, factor analysis, and cluster analysis. Univariate and multivariate Cox proportional hazard models were used to assess the associations between hemoglobin trajectories and the incidence of dementia.

Results
We included 20,195 of 235,742 female participants. New dementia (N = 2664) was developed during follow-up period (2010–2015). Five hemoglobin trajectories were identified: high, mid, low, increasing, and decreasing. With high as a reference, the hazard ratios (HRs) for low and decreasing trajectories were significant, 1.28 (95% confidence interval [CI], 1.13–1.45) and 1.21 (95% CI, 1.10–1.34) in univariate models, respectively. However, only the HR for the decreasing trajectory was significant, 1.12 (95% CI, 1.01–1.24) after adjustment for confounders.

Conclusion
The decreasing trajectory of hemoglobin levels within the normal range was associated with dementia. Even females aged 55–79 years without anemia might be vulnerable to dementia development risk.