bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antidepressant fluoxetine alleviates colitis by reshaping intestinal microenvironment
Authors: Teng Shuo , Yang Yi , Zhang Wanru , Li Xiangji , Li Wenkun , Cui Zilu , Min Li , Wu Jing 
Published: March 2024

Abstract
Background
The impact of antidepressants on Inflammatory bowel diseases (IBD) has been extensively studied. However, the biological effects and molecular mechanisms of antidepressants in alleviating colitis remain unclear.

Methods
We systematically assessed how antidepressants (fluoxetine, fluvoxamine and venlafaxine) affected IBD and chose fluoxetine, the most effective one, for mechanism studies. We treated the C56BL/6 mice of the IBD model with fluoxetine and their controls. We initially assessed the severity of intestinal inflammation in mice by body weight loss, disease Activity Index scores and the length of the colon. The H&E staining and immunohistochemical staining of MUC2 of colon sections were performed to observe the pathological changes. RT-qPCR and western blot were conducted to assess the expression level of the barrier and inflammation-associated genes. Then, single-cell RNA sequencing was performed on mouse intestinal mucosa. Seurat was used to visualize the data. Uniform Manifold Approximation and Projection (UMAP) was used to perform the dimensionality reduction. Cell Chat package was used to perform cell–cell communication analysis. Monocle was used to conduct developmental pseudotime analysis. Last, RT-qPCR, western blot and immunofluorescence staining were conducted to test the phenomenon discovered by single-cell RNA sequencing in vitro.

Results
We found that fluoxetine treatment significantly alleviated colon inflammation. Notably, single-cell RNA sequencing analysis revealed that fluoxetine affected the distribution of different cell clusters, cell–cell communication and KEGG pathway enrichment. Under the treatment of fluoxetine, enterocytes, Goblet cells and stem cells became the dominating cells. The pseudotime analysis showed that there was a trend for M1 macrophages to differentiate into M2 macrophages. Lastly, we tested this phenomenon in vitro, which exhibited anti-inflammatory effects on enterocytes.

Conclusions
Fluoxetine exhibited anti-inflammatory effects on intestinal mucosa via remodeling of the intestinal cells and macrophages, which reveals that fluoxetine is a promising therapeutic drug for the treatment of IBD and psychiatric comorbidities.
Echocardiographic abnormalities and joint hypermobility in Chinese patients with Osteogenesis imperfecta
Authors: Mei Yazhao , Jiang Yunyi , Shen Li , Meng Zheying , Zhang Zhenlin , Zhang Hao 
Published: March 2024

Abstract
Background
Very little is known about the characteristics of echocardiographic abnormalities and joint hypermobility in Chinese patients with osteogenesis imperfecta (OI). The aim of our study was to investigate the characteristics, prevalence and correlation of echocardiographic abnormalities and joint hypermobility in Chinese patients with OI.

Methods
A cross-sectional comparative study was conducted in pediatric and adult OI patients who were matched in age and sex with healthy controls. Transthoracic echocardiography was performed in all patients and controls, and parameters were indexed for body surface area (BSA). The Beighton score was used to evaluate the degree of joint hypermobility.

Results
A total of 48 patients with OI (25 juveniles and 23 adults) and 129 age- and sex-matched healthy controls (79 juveniles and 50 adults) were studied. Four genes (COL1A1, COL1A2, IFITM5, and WNT1) and 39 different mutation loci were identified in our study. Mild valvular regurgitation was the most common cardiac abnormality: mild mitral and tricuspid regurgitation was found in 12% and 36% of pediatric OI patients, respectively; among 23 OI adults, 13% and 17% of patients had mild mitral and tricuspid regurgitation, respectively, and 4% had mild aortic regurgitation. In multiple regression analysis, OI was the key predictor of left atrium diameter (LAD) (β=-3.670, P < 0.001) and fractional shortening (FS) (β = 3.005, P = 0.037) in juveniles, whereas for adults, OI was a significant predictor of LAD (β=-3.621, P < 0.001) and left ventricular mass (LVM) (β = 58.928, P < 0.001). The percentages of generalized joint hypermobility in OI juveniles and adults were 56% and 20%, respectively. Additionally, only in the OI juvenile group did the results of the Mann‒Whitney U test show that the degree of joint hypermobility was significantly different between the echocardiographic normal and abnormal groups (P = 0.004).

Conclusions
Mild valvular regurgitation was the most common cardiac abnormality in both OI juveniles and adults. Compared with OI adults, OI juveniles had more prevalent and wider joint hypermobility. Echocardiographic abnormalities may imply that the impairment of type I collagen is more serious in OI. Baseline echocardiography should be performed in OI patients as early as possible.
Recurrent syncope due to ischemia with non-obstructive coronary artery disease: a case report
Authors: Huang Bihan , Han Xueying , Xie Peiyi , Chen Shaoyuan 
Published: March 2024

Abstract
Background
Ischemia with non-obstructive coronary artery disease is a prevalent form of ischemic heart disease. The majority of ischemia with non-obstructive coronary artery disease cases are attributed to underlying factors such as coronary microvascular dysfunction (CMD) and/or coronary artery spasm. Ischemia with non-obstructive coronary artery disease can present with various clinical manifestations. Recurrent syncope is an atypical complaint in patients with ischemia with non-obstructive coronary artery disease.

Case presentation
This case report describes the presentation of a 58-year-old Chinese male patient who experienced repeated episodes of syncope. The syncope was found to be caused by concomitant coronary artery spasm and presumptive coronary microvascular dysfunctionc suggested by “slow flow” on coronary angiography. The patient was prescribed diltiazem sustained-release capsules, nicorandil, and atorvastatin. During the three-month follow-up conducted on our outpatient basis, the patient did not experience a recurrence of syncope.

Conclusion
This study highlights the importance of considering ischemia with non-obstructive coronary artery disease as a potential cause of syncope in the differential diagnosis. It emphasizes the need for early diagnosis of ischemia with non-obstructive coronary artery disease to facilitate more effective management strategies.
A modified LSTM with QoS aware hybrid AVO algorithm to enhance resource allocation in D2D communication
Authors: Pasha Shaik Ahmed , Mohamad Noor Mohammed Vali 
Published: March 2024

AbstractIn communication technologies, device-to-device (D2D) communication is essential for resource management and power control, which are major research concerns nowadays. D2D resource allocation involves dividing vital resources, such as time, power, and spectrum, among several devices. Each device can connect to other devices via one or more frequency channels. D2D communication shares the cellular user resources, while signal power transmission causes interference to the users who share the same channel. So, there is a need to control the power of the D2D device to prevent interference. For proper power control and optimization of multi-channel D2D communication, which is a challenging task, we proposed a deep learning approach incorporating a hybrid resource allocation framework. This framework aims to increase the sum rate of D2D user equipment (DUE) while considering quality of service (QoS) factors like limiting interference to cellular user equipment (CUE) and guaranteeing individual DUE rates above a certain threshold. The proposed resource allocation scheme combines two methods, namely a metaheuristic hybrid particle swarm Cauchy approach to African vulture optimization (HPSCAV) and a modified long short-term memory (MLSTM) based approach. The HPSCAV scheme helps to ensure that the QoS constraints are met, while the MLSTM-based approach is utilized for efficient resource allocation by optimizing the power and improving it with HPSCAV. Simulation results validate that the proposed model achieved better performance in various metrics such as system capacity, power consumption, spectral efficiency (SE), and energy efficiency (EE).
Video laryngoscopy versus direct laryngoscopy in achieving successful emergency endotracheal intubations: a systematic review and meta-analysis of randomized controlled trials
Authors: Alsabri Mohammed , Abdelwahab Omar Ahmed , Elsnhory Ahmed Bostamy , Diab Rehab Adel , Sabesan Vaishnavi , Ayyan Muhammad , McClean Christopher , Alhadheri Ayman 
Published: March 2024

Abstract
Background
Intubating a patient in an emergent setting presents significant challenges compared to planned intubation in an operating room. This study aims to compare video laryngoscopy versus direct laryngoscopy in achieving successful endotracheal intubation on the first attempt in emergency intubations, irrespective of the clinical setting.

Methods
We systematically searched PubMed, Scopus, Web of Science, and the Cochrane Central Register of Controlled Trials from inception until 27 February 2023. We included only randomized controlled trials that included patients who had undergone emergent endotracheal intubation for any indication, regardless of the clinical setting. We used the Cochrane risk-of-bias assessment tool 2 (ROB2) to assess the included studies. We used the mean difference (MD) and risk ratio (RR), with the corresponding 95% confidence interval (CI), to pool the continuous and dichotomous variables, respectively.

Results
Fourteen studies were included with a total of 2470 patients. The overall analysis favored video laryngoscopy over direct laryngoscopy in first-attempt success rate (RR = 1.09, 95% CI [1.02, 1.18], P = 0.02), first-attempt intubation time (MD =  − 6.92, 95% CI [− 12.86, − 0.99], P = 0.02), intubation difficulty score (MD =  − 0.62, 95% CI [− 0.86, − 0.37], P < 0.001), peri-intubation percentage of glottis opening (MD = 24.91, 95% CI [11.18, 38.64], P < 0.001), upper airway injuries (RR = 0.15, 95% CI [0.04, 0.56], P = 0.005), and esophageal intubation (RR = 0.37, 95% CI [0.15, 0.94], P = 0.04). However, no difference between the two groups was found regarding the overall intubation success rate (P > 0.05).

Conclusion
In emergency intubations, video laryngoscopy is preferred to direct laryngoscopy in achieving successful intubation on the first attempt and was associated with a lower incidence of complications.
Preparation of VX765 sodium alginate nanogels and evaluation of their therapeutic effect via local injection on myocardial infarction in rats
Authors: Liu Jianlong , Tian Qingxin , Zhang Mingxiao 
Published: March 2024

AbstractMyocardial Infarction (MI) is major cause of heart failure, highlighting the critical need for effective therapeutic strategies to improve cardiac repair. This study investigated the cardioprotective effects of VX765-coated polyethyleneimine (PEI)/sodium alginate (AG) composite nanogels (AG/PEI-VX765 NGs) in a rat model of MI. Additionally, AG-VX765 NGs and PEI-VX765 nanospheres (NPs) were synthesized and tested to compare their efficacy. MI was caused in rats by ligating the left anterior descending branch of the coronary artery, and the rats were grouped and set as Sham, MI, MI + VX765, MI + AG-VX765NGs, MI + PEI-VX765NPs, and MI + AG/PEI-VX765NGs. Results demonstrate that AG/PEI-VX765NGs were non-toxic and exhibited a sustained release of VX765. In vivo, experiments demonstrated that all treatment groups significantly enhanced cardiac function, reduced infarct size, fibrosis, and apoptosis in rats with MI, with the MI + AG/PEI-VX765NGs group exhibiting the most favorable outcomes. Our findings indicate that AG/PEI-VX765NGs represent a promising therapeutic approach for MI treatment.
Multiple sclerosis and personality traits: associations with depression and anxiety
Authors: Vaheb Saeed , Mokary Yousef , Yazdan Panah Mohammad , Shaygannejad Aysa , Afshari-Safavi Alireza , Ghasemi Majid , Shaygannejad Vahid , Moases Ghaffary Elham , Mirmosayyeb Omid 
Published: March 2024

Abstract
Background
Depression and anxiety are commonly observed in people with multiple sclerosis (pwMS). There is a growing body of literature supporting the hypothesis that personality traits can influence the mood disorders. This study aimed to investigate the personality traits and their relationships with depression and anxiety among pwMS.

Methods
234 pwMS were involved in this cross-sectional study. Personality traits, depression, and anxiety were assessed using the NEO Five-Factor Inventory (NEO-FFI) and Hospital Anxiety and Depression Scale (HADS), respectively. Pearson's correlation coefficient and generalized linear model were employed to evaluate the relationships between demographic and clinical characteristics, NEO-FFI, and HADS subscales.

Results
In pwMS, longer disease duration was significantly associated with lower level of conscientiousness (β = − 0.23, p = 0.008) and agreeableness (β = − 0.2, p = 0.01). Moreover, higher expanded disability status scale (EDSS) of pwMS had a significant relationship with higher level of neuroticism (β = 0.89, p = 0.01). Increased level of neuroticism was significantly correlated with lower level of extraversion (r = − 0.28, p < 0.001), openness (r = − 0.37, p < 0.001), agreeableness (r = − 0.31, p < 0.001), and conscientiousness (r = − 0.45, p < 0.001). PwMS with higher level of conscientiousness showed more extraversion (r = 0.23, p < 0.001), openness (r = 0.61, p < 0.001), and agreeableness (r = 0.41, p < 0.001). Elevated level of neuroticism was significantly associated with higher level of anxiety (β = 0.47, p < 0.001) and depression (β = 0.11, p < 0.001) among pwMS.

Conclusion
The co-occurrence of depression and anxiety is probably associated with neuroticism among pwMS. Additionally, the impact of personality traits extends to influencing key disease aspects such as physical disability and disease duration in MS.
Rejuvenating classical brain electrophysiology source localization methods with spatial graph Fourier filters for source extents estimation
Authors: Yang Shihao , Jiao Meng , Xiang Jing , Fotedar Neel , Sun Hai , Liu Feng 
Published: March 2024

AbstractEEG/MEG source imaging (ESI) aims to find the underlying brain sources to explain the observed EEG or MEG measurement. Multiple classical approaches have been proposed to solve the ESI problem based on different neurophysiological assumptions. To support clinical decision-making, it is important to estimate not only the exact location of the source signal but also the extended source activation regions. Existing methods may render over-diffuse or sparse solutions, which limit the source extent estimation accuracy. In this work, we leverage the graph structures defined in the 3D mesh of the brain and the spatial graph Fourier transform (GFT) to decompose the spatial graph structure into sub-spaces of low-, medium-, and high-frequency basis. We propose to use the low-frequency basis of spatial graph filters to approximate the extended areas of brain activation and embed the GFT into the classical ESI methods. We validated the classical source localization methods with the corresponding improved version using GFT in both synthetic data and real data. We found the proposed method can effectively reconstruct focal source patterns and significantly improve the performance compared to the classical algorithms.
Epicardial fat thickness among neonates of diabetic mothers attending the neonatal intensive care unit at Fayoum University Hospital: a case control study
Authors: Abd El Moktader Ahmed M. , Yousef Remon M. , Safwat Ahmed , Borayek Heba A. 
Published: March 2024

Abstract
Background
Using conventional echocardiography, this study aimed to evaluate the epicardial fat thickness (EFT) and its role in discriminating infants of diabetic mothers (IDMs) from those of non-diabetic mothers (INDMs) and to assess its prognostic role in IDMs. This case control study was conducted at the Neonatology and Cardiology Units of Pediatric Department, Fayoum University Hospital, Egypt, between February and September 2023. A total of 54 neonates were enrolled into three groups: 18 IDMs with well-controlled diabetes mellitus (DM), 18 IDMs with poorly controlled DM, and 18 INDMs.

Results
The sensitivity, specificity, and cutoff of EFT were 100%, 100%, and 3.950 mm for detecting cases of IDMs and were 66.7%, 72.2%, and 5.100 mm for differentiating controlled from uncontrolled diabetic mothers, respectively. The interventricular septum in diastole (IVSd), interventricular septum in systole (IVSs), estimated pulmonary artery pressure (PAP), left ventricle (LV) Tei index, and isovolumetric relaxation time (IVRT) of LV all showed a positive correlation with EFT (r = 0.35, 0.31, 0.41, 0.34, and 0.39; P = 0.009, 0.025, 0.002, 0.01, and 0.003; respectively). There was a significant negative correlation between EFT and left ventricular internal dimensions in diastole (LVIDd) and left ventricular internal dimensions in systole (LVIDs) (r =  − 0.44 and 0.42, P = 0.001 and 0.001). Regarding tissue Doppler, there was a significantly higher Tei index in group I cases compared to control (0.59 ± 0.10 vs. 0.49 ± 0.09, P < 0.001).

Conclusions
The EFT is higher in IDMs than in INDMs, with a positive correlation with birth weight, IVSd, IVSs, Tei index of mitral, IVRT, and ESPAP and a negative correlation with LVIDd and LVIDs. Neonatal EFT can be used as one of the helpful parameters to detect IDMs. Also, it may be used as one of the prognostic factors in IDMs as it is positively correlated with the diastolic function of the LV.
Neonatal Aromatase Inhibition Blocked Defeminization of AVPV Kiss1 Neurons and LH Surge-Generating System in Male Rats
Authors: Yamada Koki , Mano Tetsuya , Hazim Safiullah , Takizawa Marina , Inoue Naoko , Uenoyama Yoshihisa , Tsukamura Hiroko 
Published: March 2024

Abstract
The neuroendocrine system that controls the preovulatory surge of gonadotropin-releasing hormone (GnRH)/luteinizing hormone (LH), which triggers ovulation in female mammals, is sexually differentiated in rodents. A transient increase in circulating testosterone levels in male rats within a few hours of birth is primarily responsible for the defeminization of anteroventral periventricular nucleus (AVPV) kisspeptin neurons, which are critical regulators of the GnRH/LH surge. The present study aimed to determine whether neonatal estradiol-17β (E2) converted from testosterone by aromatase primarily causes the defeminization of AVPV kisspeptin neurons and the surge of GnRH/LH in male rodents. The results of the present study showed that the neonatal administration of letrozole (LET), a nonsteroidal aromatase inhibitor, within 2 hours of birth rescued AVPV Kiss1 expression and the LH surge in adult male rats, while the neonatal administration of testosterone propionate (TP) irreversibly attenuated AVPV Kiss1 expression and the LH surge in adult female rats. Furthermore, the neonatal LET-treated Kiss1-Cre–activated tdTomato reporter males exhibited a comparable number of AVPV Kiss1-Cre–activated tdTomato-expressing cells to that of vehicle-treated female rats, while neonatal TP-treated females showed fewer AVPV Kiss1-Cre–activated tdTomato-expressing cells than vehicle-treated females. Moreover, neonatal TP administration significantly decreased the number of arcuate Kiss1-expressing and Kiss1-Cre–activated tdTomato-positive cells and suppressed LH pulses in adult gonadectomized female rats; however, neonatal LET administration failed to affect them. These results suggest that E2 converted from neonatal testosterone is primarily responsible for the defeminization of AVPV kisspeptin neurons and the subsequent GnRH/LH surge generation in male rats.
TÜRK EL SANATLARINDA ARTİSTİK EL SANATLARI VE GELENEKSEL EL SANATLARI ARASINDA Kİ BAĞLAM
Authors: SÖYÜK GÜVEN Mihrinaz 
Published: March 2024

Kaynağını insanoğlunun binlerce yıllık birikiminden alan el sanatları, zamanla modern çağa ayak uydurup bir değişim dinamiği içerisinde yerini almıştır. Önemli bir kültürel miras kaynağı olan ve ait olduğu toplumda şekillenerek günümüze kültürel miras ürünü olarak ulaşan el sanatları, oldukça önemli bir gelir alanı oluşturmaktadır. Anadolu toprakları üzerinde geçmişte var olmuş birçok uygarlığın birikimlerinden elde edilen ürünler, ekonomik işlevinin dışında kültürel miras işlevini de sürdürmektedir. Geleneksel kültürün el sanatları alanlarından olan yapma bebekçilik, geleneksel başlık, Keçecilik, sepetçilik, deri işçiliği, ahşap işçiliği, takı, dantel, oyalar vb. gibi sanat alanları ait olduğu toplumun sanatsal ve kültürel özelliklerini yansıtmaktadırlar. El sanatları malzeme ve teknik yönünden geleneksel yöntemlerin kullanılarak üretildiği ve ait olduğu toplumun geleneksel kültürünü yansıtan önemli ürünlerdir. Günümüzde bu ürünler artistik ve geleneksel olarak ayrışmaktadır.
Çalışmada, modern çağın getirisi olan sanayileşme ve popüler kültür ile üretilen artistik el sanatları ve kültür tarihi açısından gün geçtikçe yok olmaya maruz kalan geleneksel el sanatları arasında ki bağlam ele alınmıştır. Bu amaç doğrultusunda makaleler, kitaplar, tezler ve görsel veriler incelenmiş ve artistik el sanatları ve geleneksel el sanatları arasında bağlam örneklerle belirtilmiştir.Turkish handicrafts, which takes its source from the thousands of years of human experience, has taken its place in a dynamic of change by keeping up with the modern age over time. Handicrafts, which are an important source of cultural heritage and have been shaped in the society it belongs to, have reached today as a traditional cultural product and as a touristic product, today it constitutes an important income area. The Anatolia’n lands in the past continue their cultural heritage function apart from their economic function. Artifical dolls, traditional headdresses, felt making, basketry, leather work, wood and woodworking, jewelry, lace and needlework, which are among the handicrafts of the traditional culture, reflect the artisticand cultural characteristics of the society they belong to.
In the study, artsitic handicarfts produced with industrialization and popular culture, which are the returns of the modern age, and traditional handicrafts that are subject to extinction day by day in terms of cultural history are discussed. For this purpose, articles, boks, theses and visual data were examined and the context between artistic handicrafts and tarditional handicrafts, was indicated with examples.
Shakespeare’s Histories on Screen: Adaptation, Race and Intersectionality, Jennie M. Votava (2023)
Authors: Mullini Roberta 
Published: March 2024

Review of: Shakespeare’s Histories on Screen: Adaptation, Race and Intersectionality, Jennie M. Votava (2023)
London, New York, Oxford, New Delhi and Sydney: Bloomsbury and The Arden Shakespeare, 260 pp.,
ISBN 978-1-35032-664-4, h/bk, £80.00
ISBN 978-1-35032-665-1, ebook, £72