bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alien marine macrophytes in Greece: a review
Authors: Tsiamis Konstantinos , Panayotidis Panayotis , Zenetos Argyro 
Published: August 2008

AbstractBy October 2007, a total of 31 alien marine macrophytic species had been recorded on Greek coasts. Following a critical review of these findings, these species were classified as established (9 species), casual (8 species) and debatable (14 species). There were also 23 species found in the Greek marine flora that are excluded from the list of alien macroalgae. Brief remarks are provided for the debatable species. Based on the distribution of the alien species, four are considered as invasive, although their impact on the native vegetation has not yet been documented. A trend analysis revealed that most alien species (65% of current total) were found in the period 1971–2007. Shipping contributes to most alien macroalgal immigration (48%), followed by progressive immigration via the Suez Canal (33%), while aquaculture plays a minor role (16%), unlike the western Mediterranean Sea where aquaculture accounts for 73% of the macrophyte introductions.
Dynamics and patterns of algal colonization on mechanically damaged and dead colonies of the coral Porites lutea
Authors: Titlyanov Eduard A. , Titlyanova Tamara V. , Chapman David J. 
Published: August 2008

Abstract
We studied (1) the dynamics of colonization by epilithic algae on mechanically damaged colonies of the coral Porites lutea, (2) the dynamics of algal colonization on dead coral fragments (coral pebbles), (3) and regeneration rates of the damaged corals under a broad range of natural light conditions on the fringing reef of Sesoko Island (Okinawa, Japan). After 1 month (of the experiment), 26 algal species occupied damaged coral areas with a projected areal cover of 1–7%. Colonizers were mainly diatoms, Cyanobacteria, filamentous green, brown and red algae. During this period, the algal settlers were not an impediment to coral polyp recovery. The recovery rate of damaged coral tissue was highest after the first month, amounting to approximately 0.15 mm day-1 under bright light (70–90% of incident surface photosynthetically active radiation, PAR0), 0.14 mm day-1 under moderate light (20–30% PAR0) and 0.07 mm day-1 under low light (2–5% PAR0). After 3 months, 58 algal species had settled onto lesions and 43 species onto coral pebbles. Projected areal cover of the algae was 30–90%. After the second month of the experiment, the recovery rates of corals declined sharply to 0.02–0.04 mm day-1. Under high and moderate light intensities, the measured parameters were similar (with the exception of the number of algal settlers). Under low light, the number, the density of algal settlers and the regeneration rate of polyps on damaged corals were significantly reduced. The algal turf community was formed under light intensities from 20% to 90% PAR0, but was not formed under low light.
Blended Museum – Perspektiven für eine vielfältige Besuchererfahrung (Enhancing Visitor Experience through Information Design and Interaction)
Authors: Klinkhammer Daniel , Reiterer Harald 
Published: August 2008

Zusammenfassung
Durch den Einsatz von Informations- und Kommunikationstechnologien (IuK) hat sich das Spektrum musealer Informations-präsentation und Besucherpartizipation erweitert. Museale Inhalte können hierdurch nicht nur real, sondern auch virtuell zugänglich gemacht werden. Im Ansatz des Blended Museums wird dem Konzept des Blended Learning folgend versucht, durch Kombination verschiedener Medien und Methoden eine didaktisch sinnvolle Verknüpfung zwischen dem realen und virtuellen Museum zu erstellen. Ziel dieser Vermischung ist es vielfältige Besuchererfahrungen (Visitor Experience) zu ermöglichen, welche durch innovative Interaktionstechniken, holistisches Informationsdesign und neuartige Vermittlungs-strategien erzielt werden sollen.
Wer sind die Besucher des virtuellen Museums und welche Interessen haben sie? (Who are the Visitors of the Virtual Museum and What are they Interested in?)
Authors: Schweibenz Werner 
Published: August 2008

Zusammenfassung
Der Beitrag basiert auf einer Analyse der internationalen Forschungsliteratur und geht folgenden Fragen nach: wie ist das Verhältnis von Museumsbesuch und Internetnutzung in Deutschland, welche Informationsbedürfnisse haben virtuelle Museumsbesucher im Internet und wie verhalten sie sich, wie stehen sie zu hohen technischen Anforderungen von Web-Angeboten? Aus der Literaturanalyse werden Schlussfolgerungen für die Vermittlung und den Einsatz von Wissensmedien für virtuelle Museen im Internet gezogen.
Digitale Museumsanwendungen (Digital Museum Appliances)
Authors: Göbel Stefan , Geelhaar Jens 
Published: August 2008

Zusammenfassung
Viele Museen suchen heutzutage neue Methoden und Wege, um Museen attraktiver zu gestalten und weitere Museumsbesucher und Zielgruppen anzusprechen. Eine Ausprägung davon stellen Science Center oder Themenparks dar, aber auch Kinder-, Kunst- und Technikmuseen mit digitalen Museum Guides oder „Exponaten zum Anfassen”. Basierend auf diesem Trend haben das ZGDV Darmstadt und die Bauhaus-Universität Weimar unabhängig voneinander multimediale Museumsanwendungen entwickelt, die insbesondere das jüngere Publikum in die Museen locken als auch „etablierte” Museumsgänger durch einen digital erweiterten Wissens- und Erlebnisraum ansprechen soll. Die Fallbeispiele des ZGDV „DinoSim Senckenberg”, „art-E-fact” und das innovative Präsentationssystem „iPX” repräsentieren interaktive Museumsanwendungen zur wissenschaftlich-technischen Simulation von Dinosaurier Laufstudien und der Exploration von Gemälden und Kunstobjekten sowie des menschlichen Körpers innerhalb der seitens des Heinz Nixdorf Museumsforum initiierten Sonderausstellung „Computer.Mensch” direkt vor Ort im Museum; „DinoExplorer Senckenberg” bietet eine virtuelle Umgebung zur spielerischen Exploration von Museumsräumen und Exponaten in Form einer emulierten Museumsrallye. Das digitale Osmantinum spricht den Literatur interessierten Besucher an und ist als mobiles Informations- und Führungssystem auf der Basis eines PDA's konzipiert, ohne die besondere Stimmung der Museumsräume zu stören.
Accessibility-orientierte Anforderungsanalyse (AORA) (Accessibility-oriented Requirement Analysis (AORA))
Authors: Siegemund Katja 
Published: August 2008

Zusammenfassung
Der Artikel stellt Richtlinien für eine Accessibility-orientierte Anforderungsanalyse (AORA) dar, die auf dem Konzept der Benutzerorientierung, dem Usage-Centered Design und dem Usability Engineering Lifecycle (Mayhew 1999) beruht. Ziel ist es, das oft vorherrschende Kommunikationsproblem zwischen Kunden und Softwareentwicklern mittels einer für beide Seiten einfachen, intuitiven und weiterverwendbaren Möglichkeit der Anforderungserfassung zu kompensieren. Accessibility-Belange werden dabei bereits während der Anforderungsanalyse einbezogen. Besonderer Wert wird dabei auf die Nutzerpartizipation, die Berücksichtigung von Accessibility-Kriterien sowie die Einbeziehung von Stakeholdern gelegt. Um die Ergebnisse wiederverwendbar zu gestalten, wurden Techniken der Domänen-Analyse eingesetzt. Um die oft schwierige Identifikation und Darstellung von Beziehungen zwischen nicht-funktionalen Eigenschaften und Aspekten des Nutzungskontexts (z.B. Nutzereigenschaften, Arbeitsumfeld) zu ermöglichen, wurde CONFEAT (Context-driven Feature Tree Generation) entwickelt – eine Methode zur kontextbasierten Erstellung von Eigenschaftsbäumen. Hierfür wurden Kreuztabellen aus der formalen Begriffsanalyse (FCA) mit Eigenschaftsbäumen (Feature Trees) aus der Softwaretechnik kombiniert.
Inflammatory Gene Polymorphisms and Susceptibility to Kawasaki Disease and Its Arterial Sequelae
Authors: Cheung Yiu-fai , Huang Guo-ying , Chen Shu-bao , Liu Xiao-qin , Xi Li , Liang Xue-cun , Huang Mei-rong , Chen Sun , Huang Li-su , Liu Xiao-qing , Chan Koon-wing , Lau Yu-lung 
Published: August 2008

OBJECTIVE. We tested the hypothesis that single-nucleotide polymorphisms of inflammatory genes C-reactive protein (CRP) and tumor necrosis factor α (TNF-α) may exert influence on susceptibility to Kawasaki disease and its arterial sequelae.
METHODS. We analyzed the CRP +1444 C→T and TNF-α −308 G→A polymorphisms in 167 patients aged 8.9 ± 4.1 years with a history of Kawasaki disease (73 with and 94 without coronary aneurysms) and 124 healthy control subjects. For patients with Kawasaki disease, we further determined whether these single-nucleotide polymorphisms were associated with coronary aneurysms, carotid arterial stiffening, and intima-media thickness.
RESULTS. Genotypic and allelic frequencies of CRP +1444 for T carrier and TNF-α −308 for A carrier were significantly higher in patients than in control subjects. The genotypic and allelic distributions did not differ between patients with and those without coronary aneurysms; however, patients with CRP +1444 CT/TT genotype compared with those with a CC genotype and patients with TNF-α −308 GA/AA genotype compared with those with a GG genotype had significantly greater carotid arterial stiffness and intima-media thickness. Carriers of both CRP +1444 T allele and TNF-α −308 A allele had the highest susceptibility to Kawasaki disease and a significant trend of increased arterial stiffness and intima-media thickness compared with those who carried either 1 or none of the rare alleles. Multiple linear regression analysis identified CRP +1444 allele carrier as a significant determinant of both carotid stiffness and carotid intima-media thickness and TNF-α −308 A allele carrier as a determinant of only intima-media thickness.
CONCLUSIONS. Our findings suggest that CRP +1444 C→T and TNF-α −308 G→A polymorphisms are associated with predisposition to Kawasaki disease and, in patients with Kawasaki disease, increased carotid arterial stiffness and intima-media thickness in the long-term.
Measuring pyrethroids in sediment pore water using matrix-solid phase microextraction
Authors: Hunter Wesley , Yang Yu , Reichenberg Fredrik , Mayer Philipp , Gan Jianying 
Published: August 2008

Abstract
Pyrethroids are hydrophobic insecticides commonly used in both agricultural and urban environments. Their high toxicity to aquatic organisms, including benthic invertebrates, and detection in the sediment at many locations in California, USA, have spawned interest in understanding their bioavailability in bed sediments. A recent study showed good correlation between uptake of 14C-permethrin in Chironomus tentans and solid-phase microextraction (SPME) fibers in sediments. The present study was directed at the development of an SPME technique applicable to trace levels of nonlabeled pyrethroids in sediment. Disposable polydimethylsiloxane fibers were used to detect freely dissolved pore-water concentrations of bifenthrin, fenpropathrin, cis-per-methrin, trans-permethrin, cyfluthrin, cypermethrin, and esfenvalerate under agitated and static conditions. Partition equilibrium between fiber and sediment was reached in &lt;5 d when the samples were agitated on a shaker at low speed, while much longer times (&gt;23 d) were needed without agitation. Polydimethylsiloxane to water partition ratios (KPDMS) of the seven pyrethroids were measured separately and ranged from 2.83 × 105 to 1.89 × 106. When applied to field-contaminated sediments, agitated matrix-SPME was able to detect pore-water concentrations as low as 0.1 ng/L. The method developed in the present study may be coupled with bioassays to gain mechanistic understanding of factors affecting pyrethroid toxicities, and applied to field samples to better predict sediment toxicities from pyrethroid contamination.
Fatty acid composition of the estuarine amphipod, Melita plumulosa (zeidler): Link between diet and fecundity
Authors: Hyne Ross V. , Sánchez-Bayo Francisco , Bryan Ashley D. , Johnston Emma L. , Mann Reinier M. 
Published: August 2008

Abstract
The influence of various diets on the survival, fecundity, and the polyunsaturated fatty acid (PUFA) composition of the benthic estuarine amphipod Melita plumulosa (Zeidler) in laboratory cultures were determined. Apart from a natural silty sediment, six commercial food supplements were examined: an omega-6 PUFA enriched Spirulina-based dry powder, Sera® micron; a shrimp-based pellet food; an omega-3 PUFA enriched algal paste, Rotiselco®-ALG; an omega-6 PUFA enriched algal dry powder, AlgaMac-ARA (arachidonic acid); flaxseed meal; and an omega-3 PUFA enriched dry powder, Frippak®. We have previously established that M. plumulosa cultures perform poorly and eventually decline if provided with silty sediment alone, but will thrive if supplemented with Sera micron. Conversely, if the amphipods are cultured on a nutrient-depleted sand substrate, Sera micron alone does not constitute an adequate feed. The major difference in the fatty acid composition of M. plumulosa cultured on silty sediment compared to amphipods cultured on a sand substrate and both fed Sera micron was an increase in the ratio of omega-3 to omega-6 PUFAs, indicating that the silty sediment provides additional food sources rich in omega-3 PUFAs. Furthermore, amphipods cultured in sand and fed any of the three algal-based foods or the Frippak powder as the sole food source had poor survival rates, although Sera micron maintained the best survival—this was attributed to it containing high amounts of β-carotene and terpenoids. Melita plumulosa fed a mixture of Sera micron in conjunction with the omega-3 PUFA enriched Rotiselco-ALG and cultured on a silty substrate were found to have good fecundity with low variability.
Incidence of Newly Diagnosed Cancer After Cerebral Venous Thrombosis
Authors: van de Munckhof Anita , Verhoeven Jamie I. , Vaartjes Ilonca C. H. , van Es Nick , de Leeuw Frank-Erik , Coutinho Jonathan M. 
Published: February 2025

ImportanceActive cancer is a risk factor for cerebral venous thrombosis (CVT), but whether CVT is associated with occult cancer is unknown.ObjectiveTo evaluate the incidence of newly diagnosed cancer after CVT.Design, Setting, and ParticipantsThis population-based cohort study used data from the Dutch Hospital Discharge Registry from January 1, 1997, to July 1, 2020. Analyses were conducted between June 2023 and April 2024. Patients admitted with a first-ever CVT were included. Patients with a history of cancer or diagnosed with cancer during hospitalization for CVT were excluded.ExposureCVT was identified using International Classification of Diseases, Ninth Revision (ICD-9) and International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10) codes.Main Outcomes and MeasuresThe main outcome was cumulative incidence of cancer after CVT. Standardized incidence ratios (SIRs) were calculated relative to a matched cohort from the general population using the Netherlands Cancer Registry.ResultsA total of 2649 patients with CVT (median [IQR] age, 44.5 [30.7-56.4] years; 1856 [70.1%] female) were included. Cancer was diagnosed in 119 patients during a median (IQR) follow-up of 4.7 (1.9-8.9) years, of whom 29 (24.4%) had hematologic cancer. The cumulative incidence of cancer was 5.9% (95% CI, 4.8%-7.2%) after 10 years and was highest in men aged 50 years or older (13.5%; 95% CI, 9.1%-18.7%). Patients with CVT had an increased rate of cancer compared with the reference cohort during the entire follow-up, but the difference narrowed over time (SIRs of 3.35 [95% CI, 2.41-4.55] and 1.40 [95% CI, 1.14-1.69] at 1 and 10 years, respectively). The rate was increased both in patients younger than 50 years (SIRs of 6.70 [95% CI, 3.97-10.59] and 1.72 [95% CI, 1.24-2.34] at 1 and 10 years, respectively) and those 50 years or older (SIRs of 2.41 [95% CI, 1.53-3.62] and 1.25 [95% CI, 0.96-1.60] at 1 and 10 years, respectively), as well as in male patients (SIRs of 3.59 [95% CI, 2.16-5.61] and 1.69 [95% CI, 1.25-2.23] at 1 and 10 years, respectively) and female patients (SIRs, 3.17 [95% CI, 1.99-4.80] and 1.22 [95% CI, 0.92-1.58] at 1 and 10 years, respectively).Conclusions and RelevanceThis cohort study of patients with CVT found an increased risk of cancer during follow-up regardless of age or sex. Men 50 years or older had the highest absolute risk, whereas younger patients had the highest relative risk. Physicians should be vigilant for signs of cancer after CVT, and further research on screening for cancer after CVT is warranted.
Bottom–Up Metasurfaces for Biotechnological Applications
Authors: Petronella Francesca , Zaccagnini Federica , Sforza Maria Laura , De Mei Vincenzo , De Sio Luciano 
Published: February 2025

AbstractMetasurfaces are the 2D counterparts of metamaterials, and their development is accelerating rapidly in the past years. This progress enables the creation of devices capable of uniquely manipulating light, with applications ranging from optical communications to remote biosensing. Metasurfaces are engineered by rational assembly of subwavelength elements, defined as meta‐atoms, giving rise to unique physical properties arising from the collective behavior of meta‐atoms. These meta‐atoms are typically organized using effective, reproducible, and precise nanofabrication methods that require a lot of effort to achieve scalable and cost‐effective metasurfaces. In contrast, bottom–up methods based on colloidal nanoparticles (NPs) have developed in the last decade as a fascinating alternative for accelerating the technological spread of metasurfaces. The present review takes stock of recent advances in the fabrication and applications of hybrid metasurfaces prepared by bottom‐up methods, resulting in disordered metasurfaces. In particular, metasurfaces prepared with plasmonic NPs are emphasized for their multifold applications, which are discussed from a biotechnology perspective. However, some examples of organized metasurfaces prepared by merging bottom–up and top–down approaches are also described. Finally, leveraging the historical disordered metasurface evolution, the review draws new perspectives for random metasurface design and applications.
Use of laryngeal muscle evoked potential recording for experimental vagus nerve stimulation
Authors: Bachmann Helen , Raedt Robrecht , Laureys Guy , Vonck Kristl 
Published: February 2025

AbstractThe laryngeal muscle evoked potential (LMEP) is a neurophysiological outcome parameter that guarantees integrity of the nerve‐electrode interface during experiments with vagus nerve stimulation (VNS). This paper discusses a large series of minimally invasive LMEP recordings in 46 female Lewis rats, implanted with a custom‐made VNS electrode around the left cervical vagus nerve. After a 3‐week recovery, LMEPs were recorded twice in each animal, with swapping the anode and cathode positions of the VNS electrode (polarity inversion). A VNS‐induced LMEP was identified as the initial negative peak wave post‐stimulation artifact, consistently recorded in all sweeps at a given stimulation output current. Latency was defined as the time from stimulation onset to this negative peak, and stimulation threshold as the lowest current showing a clear and reproducible LMEP. An LMEP response was shown by 37/46 animals (80.4%), with stimulation intensity threshold of 0.37 ± 0.27 mA and latency of 2.39 ± 0.45 ms. Administering the cathodic pulse phase first at the caudal electrode contact resulted in the shortest LMEP latencies (MWU: p = 0.049. 2.36 ± 0.43 ms vs. 2.41 ± 0.47 ms). Minimally invasive LMEP recording provides a feasible and reliable means for checking electrode functioning and correct implantation.
Understanding the Nitrogen Reduction Reaction Mechanism on CuFeO2 Photocathodes
Authors: Beßner Julian , Jacob Timo 
Published: February 2025

This study investigates the reaction pathways for the conversion of N2 to NH3 on CuFeO2 (CFO) by employing density functional theory (DFT) calculations. Concentrating on the most stable (012) surface orientation, two systems were examined: the pristine (012) surface and the corresponding oxygen defective surface. To find the thermodynamic stable pathway, the associative Heyrovský mechanism was considered, containing four different reaction pathways. The reaction intermediates predominantly interact with the iron sites on the surface, following the distal alternating reaction pathway via the formation of hydrazine. Introducing oxygen defects changes the reaction mechanism to a Mars‐van‐Krevelen‐type mechanism, avoiding the formation of hydrazine, while the Gibbs free energy of the first hydrogenation step is lowered by 1.17 eV (from 2.17 to 1.00 eV). Analyzing the charge density distribution reveals that oxygen defective surface enables CFO to facilitate a π‐backdonation between iron sites and the NRR intermediates, increasing the intermediate‐surface interaction. This indicates an enhanced catalytic activity for the nitrogen reduction reaction (NRR) by generating oxygen lattice defects in CFO.
Clinical Assessment of the Drug–Drug Interaction Potential of Omaveloxolone in Healthy Adult Participants
Authors: Zahir Hamim , Murai Masako , Wu Lucy , Valentine Michelle , Hynes Scott 
Published: February 2025

AbstractOmaveloxolone is approved in the United States and the European Union for the treatment of patients with Friedreich ataxia aged ≥16 years. It is mainly metabolized by cytochrome P450 (CYP) 3A4 in vitro. Two drug–drug interaction studies (NCT04008186 and NCT05909644) were performed to evaluate (1) the effect of drug‐metabolizing enzymes (DMEs) and drug transporter (DT) modulators on the pharmacokinetics of omaveloxolone and (2) the effect of omaveloxolone on the pharmacokinetics of DME and DT substrates. Additionally, the safety of coadministering these drugs with omaveloxolone was assessed. Coadministration of the strong CYP3A4 inhibitor itraconazole significantly increased omaveloxolone maximum plasma concentration (Cmax) and area under the plasma concentration–time curve from time 0 extrapolated to infinity (AUC0‐∞) by approximately 3‐ and 4‐fold, respectively. Conversely, coadministration with the moderate CYP3A4 inducer efavirenz decreased Cmax and AUC0‐∞ of omaveloxolone by 38.0% and 48.5%, respectively. Omaveloxolone exposure was also increased following coadministration with verapamil, a moderate CYP3A4 and P‐glycoprotein (P‐gp) inhibitor, but it was unaffected by the strong CYP2C8 inhibitor gemfibrozil. Coadministration of omaveloxolone reduced systemic exposure of the substrates of CYP3A4, CYP2C8, breast cancer resistance protein, and organic anion transporting polypeptide 1B1 but had no effect on those of P‐gp and organic cation transporter 1. Omaveloxolone was well tolerated when administered alone and in combination with the DME and DT modulators or substrates. These findings support concomitant medication precautions and dosing recommendations for omaveloxolone when coadministered with a moderate or strong CYP3A4 inhibitor or inducer, as well as the substrates of certain CYP450 enzymes or transporters.