bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Clarion Call for Change: The MLP Imperative to Center Racial Discrimination and Structural Health Inequities
Authors: Matthew Dayna Bowen , Benfer Emily A. 
Published: March 2024

AbstractAcross the country, legal and health care professionals who understand that health outcomes are most influenced by social and environmental conditions have improved patient health by adopting the interdisciplinary MLP health care delivery model. However, the MLP field cannot advance population health, let alone long-term health equity, until it addresses the structural determinants of health inequity that are rooted in discrimination, segregation, and other forms of racial and ethnic subordination.
A Data-Driven Approach to Optimizing Medical-Legal Partnership Performance and Joint Advocacy
Authors: Beck Andrew F. , Henize Adrienne W. , Klein Melissa D. , Corley Alexandra M. S. , Fink Elaine E. , Kahn Robert S. 
Published: March 2024

AbstractMedical-legal partnerships connect legal advocates to healthcare providers and settings. Maintaining effectiveness of medical-legal partnerships and consistently identifying opportunities for innovation and adaptation takes intentionality and effort. In this paper, we discuss ways in which our use of data and quality improvement methods have facilitated advocacy at both patient (client) and population levels as we collectively pursue better, more equitable outcomes.
Using Racial Justice Principles in Medical-Legal Partnership Design and Implementation
Authors: Setrini Alice 
Published: March 2024

AbstractMedical-legal partnerships (MLPs) have the potential to address racial health disparities by improving the conditions that constitute the social determinants of health. In order to live up to this potential, these partnerships must intentionally incorporate seven core racial justice principles into their design and implementation. Otherwise, they are likely to replicate the systemic barriers that lead to racialized health disparities.
The Synergy of Legal and Medical Palliative Care: Challenges and Opportunities in Palliative MLP and the Yale Experience
Authors: Iannantuoni Rebecca , Rock Emily B. , Gluck Abbe R. 
Published: March 2024

AbstractPalliative care and medical-legal partnership are complementary disciplines dedicated to integrating care to treat the whole patient and intervening before a legal or medical issue is at a crisis point. In this paper, we discuss the founding and operations of the Yale Palliative Medical Legal Partnership, give examples of typical cases, explain special considerations in this area of law, and propose areas for further research.
Conditions of Participation: Incorporating the History of Hospital Desegregation
Authors: Sanford Sallie Thieme 
Published: March 2024

AbstractOur students ought to know about the history of formal hospital segregation and desegregation. To that end, this article urges those who teach foundational health law and policy courses to do three things. First, to teach the Simkins case. Second, to swap out the usual Medicare signing ceremony picture for one that includes W. Montague Cobb, M.D., Ph.D. Third, to highlight how the implementation of that program for the elderly led, in a matter of months, to the desegregation of hospitals throughout the country.
Assessment of Resident Physician Comfort in Screening for Social Determinants of Health in a Specialty Clinic Population
Authors: Silverman Erika L. , Sandsmark Danielle K. , Field Robert I. 
Published: March 2024

AbstractThrough qualitative surveys, a team of law students, law professors, physicians, and residents explored the perceptions of neurology residents towards referral to appropriate legal resources in an academic training program. Respondents reported feeling uncomfortable screening their patients for health-harming legal needs, which many attributed to a lack of training in this area. These findings indicate that neurology residents would benefit from training on screening for social factors that may be impacting their patients’ health.
Great Trees Require Strong Roots: Evaluating Data and Delegation Doctrine Underlying Proposed Reforms to FDA’s Accelerated Approval Program
Authors: Deshmukh Anjali D. 
Published: March 2024

AbstractIn “Missing the Forest for the Trees: Aduhelm, Accelerated Approvals & the Agency,” Dr. Matthew Herder argues that agency capture and politicized discretion drive delays in confirmatory trials of accelerated approval drugs amongst other concerns at US Food and Drug Administration (FDA). In highlighting this important problem and offering nuanced insight into agency workings based in part on interviews with twenty-three unnamed FDA officials and a three-drug case study, Dr. Herder suggests two innovative solutions. However, amidst broader debates balancing agency expertise, data, and delegation, these proposed policy solutions would benefit from more corroborative evidence and consideration of institutional advantages within constitutional limits.
Leveraging Academic-Medical Legal Partnerships to Advance Health Justice
Authors: Girard Vicki W. , Cannon Yael Z. , Perry Deborah F. , Moore Eileen S. 
Published: March 2024

AbstractUnmet legal needs contribute to housing, income, and food insecurity, along with other conditions that harm health and drive health inequity. Addressing health injustice requires new tools for the next generations of lawyers, doctors, and other healthcare professionals. An interprofessional group of co-authors argue that law and medical schools and other university partners should develop and cultivate Academic Medical-Legal Partnerships (A-MLPs), which are uniquely positioned to leverage service, education, and research resources, to advance health justice.
What Can State Medical Boards Do to Effectively Address Serious Ethical Violations?
Authors: McIntosh Tristan , Pendo Elizabeth , Walsh Heidi A. , Baldwin Kari A. , King Patricia , Anderson Emily E. , Caldicott Catherine V. , Carter Jeffrey D. , Johnson Sandra H. , Mathews Katherine , Norcross William A. , Shaffer Dana C. , DuBois James M. 
Published: March 2024

AbstractState Medical Boards (SMBs) can take severe disciplinary actions (e.g., license revocation or suspension) against physicians who commit egregious wrongdoing in order to protect the public. However, there is noteworthy variability in the extent to which SMBs impose severe disciplinary action. In this manuscript, we present and synthesize a subset of 11 recommendations based on findings from our team’s larger consensus-building project that identified a list of 56 policies and legal provisions SMBs can use to better protect patients from egregious wrongdoing by physicians.
Steering into the Curves: Using Diagnosis to Support the Dignity and Autonomy of Trans Youth
Authors: Boskey Elizabeth R. , Galarneau Charlene 
Published: March 2024

AbstractThis response to Kariyawasam and Rai affirms their critique of the pathologization of trans youth but forecasts a foreseeable negative outcome of their proposed elimination of diagnosis as a prerequisite to gender-affirming care (GAC) — the risk of removing GAC entirely from the medical sphere and compromising the wellbeing of those transgender individuals for whom GAC is deeply affirming. We suggest an ethical framework of GAC that expands past a focus on autonomy to incorporate a principle of respect for persons that affirms the dignity and diversity of trans youth — recognizing the need to facilitate both medical assistance and social change.
Epidemiology of tuberculosis among children in Beijing, China, 2012–2021
Authors: Zheng Huiwen , Xiao Jing , Yang Haiming , Li Feina , Guo Yajie , Wang Yonghong , Li Deze , Chen Hao , Wang Xiaotong , Li Huimin , Shen Chen 
Published: March 2024

Abstract
Data on epidemiology trends of paediatric tuberculosis (TB) are limited in China. So, we investigated the clinical and epidemiological profiles in diagnosed TB disease and TB infection patients at Beijing Children’s Hospital. Of 3 193 patients, 51.05% had pulmonary TB (PTB) and 15.16% had extrapulmonary TB (EPTB). The most frequent forms of EPTB were TB meningitis (39.05%), pleural TB (29.75%), and disseminated TB (10.33%). PTB patients were significantly younger and associated with higher hospitalization frequency. Children aged 1–4 years exhibited higher risk of PTB and TB meningitis, and children aged 5–12 years had higher risk of EPTB. The proportion of PTB patients increased slightly from 40.9% in 2012 to 65% in 2019, and then decreased to 17.8% in 2021. The percentage of EPTB cases decreased from 18.3% in 2012 to 15.2% in 2019, but increased to 16.4% in 2021. Among EPTB cases, the largest increase was seen in TB meningitis. In conclusion, female and young children had higher risk of PTB in children. TB meningitis was the most frequent forms of EPTB among children, and young children were at high risk of TB meningitis. The distribution of different types of EPTB differed by age.
Collapses, Maxima, Multi‐Year Modulation and Trends of the Zapiola Anticyclonic Circulation: Insights From Mercator Reanalysis
Authors: Poli Lea , Artana Camila , Provost Christine , Sirven Jérôme , Le Blanc‐Pressenda Ruben 
Published: March 2024

AbstractThe Argentine Basin hosts a unique oceanic feature: the Zapiola Anticyclonic Circulation (ZAC) located above a sedimentary deposit. Taking advantage of a high‐resolution (1/12°) global ocean reanalysis (GLORYS12) we examine the ZAC over 27 years (1993–2019). The mean ZAC is bottom‐intensified with bottom currents reaching 0.10 ms−1. The ZAC volume transport ranges from −18.5 to 268 Sv with a mean of 122 Sv. The strong negative peaks correspond to occasional ZAC collapses. During large transport events (>195.4 Sv) the ZAC shows a well defined coherent gyre. Strong transport events are associated with high eddy kinetic energy (EKE) at the periphery of the ZAC (especially to the west and south). In contrast, during weak transport events (<49.8 Sv), EKE increases at the center of the ZAC and decreases at the ZAC periphery. A weak ZAC is more permeable to external mesoscale structures. Each weak event features a cyclonic eddy at the center of the ZAC carrying subantarctic cold and fresh waters. The ZAC exhibits a multi‐year modulation, with periods of 4–5 years (1993–1997, 1998–2003 and 2004–2009) of low salinity corresponding to low transport, and high salinity to high transport. Over the last 27 years, transport time series exhibit a significant negative trend of −15 Sv.decade−1 associated with a negative trend in EKE (−0.015 (m/s)2.decade−1) to the north west of the ZAC. Waters in the Zapiola region become warmer and saltier in the first 2,000 m of the water column because of the southward migration of the subtropical front.
Spatiotemporal Variations of the Effects of Aerosols on Clouds and Precipitation in an Extreme‐Rain‐Producing MCS in South China
Authors: Yun Yuxing , Zhang Da‐Lin , Gao Wenhua , Yin Jinfang , Zhao Chun , Li Jiawei , Guo Jianping , Liu Hongli 
Published: March 2024

AbstractPrevious studies focus mostly on the storm‐scale‐averaged precipitation responses to aerosols. Yet, the spatiotemporal variations of the aerosol effects can lead to localized and short‐duration precipitation changes that are more relevant for improving rainfall forecasts. Here, we investigate the cloud and precipitation responses to aerosols during different life stages and in subregions with various cloud top heights of an extreme‐rain‐producing mesoscale convective system (MCS) in South China using the coupled WRF‐Chem model. Results show mostly similar MCS‐averaged precipitation responses between the polluted and clean conditions due to compensations among the subregions. However, the spatiotemporally discretized changes are divergent. Specifically, during the developing stage, aerosols increase precipitation in all subregions through generating larger precipitating hydrometers produced from the accretion of more cloud droplets. The most prominent precipitation enhancement occurs in the subregion with the strongest clean‐condition rainfall. In the mature stage, the CCN activation abates, and so does the aerosol‐induced precipitation increase. In the mixed‐phase (−40°C < Ttop < 0°C) and cold (Ttop ≤ −40°C) cloud top subregions, aerosols also reduce the melting of the ice‐phase precipitating hydrometers, which process becomes more important to precipitation formation during the mature stage. Therefore, the drop of rainfall rate is more significant in these ice‐phase‐involved subregions, bringing the polluted precipitation to be less than that in the clean condition during the mature stage. The substantial spatiotemporal variations of the aerosol effects and the early intensification of heavy precipitation suggest the importance of incorporating aerosols in the modeling and prediction of regional heavy rainfall events.
Dysregulated CREB3 cleavage at the nuclear membrane induces karyoptosis-mediated cell death
Authors: Lee Ga-Eun , Bang Geul , Byun Jiin , Lee Cheol-Jung , Chen Weidong , Jeung Dohyun , An Hyun-Jung , Kang Han Chang , Lee Joo Young , Lee Hye Suk , Hong Young-Soo , Kim Dae Joon , Keniry Megan , Kim Jin Young , Choi Jin-Sung , Fanto Manolis , Cho Sung-Jun , Kim Kwang-Dong , Cho Yong-Yeon 
Published: March 2024

AbstractCancer cells often exhibit resistance to apoptotic cell death, but they may be vulnerable to other types of cell death. Elucidating additional mechanisms that govern cancer cell death is crucial for developing new therapies. Our research identified cyclic AMP-responsive element-binding protein 3 (CREB3) as a crucial regulator and initiator of a unique cell death mechanism known as karyoptosis. This process is characterized by nuclear shrinkage, deformation, and the loss of nuclear components following nuclear membrane rupture. We found that the N-terminal domain (aa 1-230) of full-length CREB3 (CREB3-FL), which is anchored to the nuclear inner membrane (INM), interacts with lamins and chromatin DNA. This interaction maintains a balance between the outward force exerted by tightly packed DNA and the inward constraining force, thereby preserving INM integrity. Under endoplasmic reticulum (ER) stress, aberrant cleavage of CREB3-FL at the INM leads to abnormal accumulation of the cleaved form of CREB3 (CREB3-CF). This accumulation disrupts the attachment of CREB3-FL to the INM, resulting in sudden rupture of the nuclear membrane and the onset of karyoptosis. Proteomic studies revealed that CREB3-CF overexpression induces a DNA damage response akin to that caused by UVB irradiation, which is associated with cellular senescence in cancer cells. These findings demonstrated that the dysregulation of CREB3-FL cleavage is a key factor in karyoptotic cell death. Consequently, these findings suggest new therapeutic strategies in cancer treatment that exploit the process of karyoptosis.
A Wnt10a-Notch signaling axis controls Hertwig’s epithelial root sheath cell behaviors during root furcation patterning
Authors: Sun Kai , Yu Miao , Wang Jiayu , Zhao Hu , Liu Haochen , Feng Hailan , Liu Yang , Han Dong 
Published: March 2024

AbstractHuman with bi-allelic WNT10A mutations and epithelial Wnt10a knockout mice present enlarged pulp chamber and apical displacement of the root furcation of multi-rooted teeth, known as taurodontism; thus, indicating the critical role of Wnt10a in tooth root morphogenesis. However, the endogenous mechanism by which epithelial Wnt10a regulates Hertwig’s epithelial root sheath (HERS) cellular behaviors and contributes to root furcation patterning remains unclear. In this study, we found that HERS in the presumptive root furcating region failed to elongate at an appropriate horizontal level in K14-Cre;Wnt10afl/fl mice from post-natal day 0.5 (PN0.5) to PN4.5. EdU assays and immunofluorescent staining of cyclin D1 revealed significantly decreased proliferation activity of inner enamel epithelial (IEE) cells of HERS in K14-Cre;Wnt10afl/fl mice at PN2.5 and PN3.5. Immunofluorescent staining of E-Cadherin and acetyl-α-Tubulin demonstrated that the IEE cells of HERS tended to divide perpendicularly to the horizontal plane, which impaired the horizontal extension of HERS in the presumptive root furcating region of K14-Cre;Wnt10afl/fl mice. RNA-seq and immunofluorescence showed that the expressions of Jag1 and Notch2 were downregulated in IEE cells of HERS in K14-Cre;Wnt10afl/fl mice. Furthermore, after activation of Notch signaling in K14-Cre;Wnt10afl/fl molars by Notch2 adenovirus and kidney capsule grafts, the root furcation defect was partially rescued. Taken together, our study demonstrates that an epithelial Wnt10a-Notch signaling axis is crucial for modulating HERS cell proper proliferation and horizontal-oriented division during tooth root furcation morphogenesis.
Single-cell RNA-seq reveals keratinocyte and fibroblast heterogeneity and their crosstalk via epithelial-mesenchymal transition in psoriasis
Authors: Guo Dianhao , Li Xiaokang , Wang Jing , Liu Xin , Wang Yibo , Huang Shuhong , Dang Ningning 
Published: March 2024

AbstractThe pathogenesis of psoriasis, a chronic inflammatory autoimmune skin disease with a high global prevalence, remains unclear. We performed a high-resolution single-cell RNA sequencing analysis of 94,759 cells from 13 samples, including those from psoriasis model mice and wild-type mice. We presented a single-cell atlas of the skin of imiquimod-induced mice with psoriasis and WT mice, especially the heterogeneity of keratinocytes and fibroblasts. More interestingly, we discovered that special keratinocyte subtypes and fibroblast subtypes could interact with each other through epithelial–mesenchymal transition and validated the results with drug verification. Moreover, we conducted a tentative exploration of the potential pathways involved and revealed that the IL-17 signalling pathway may be the most relevant pathway. Collectively, we revealed the full-cycle landscape of key cells associated with psoriasis and provided a more comprehensive understanding of the pathogenesis of psoriasis.
RNF166 promotes colorectal cancer progression by recognizing and destabilizing poly-ADP-ribosylated angiomotins
Authors: Li Yun , Zhang Xiangqian , Liu Na , Liu Ruijie , Zhang Wuming , Chen Lin , Chen Yongheng 
Published: March 2024

AbstractActivation of the Hippo pathway by angiomotins to limit colorectal cancer progression is prevalent, whereas the regulation of angiomotins remains elusive. In this study, we uncover the involvement of an upregulated E3 ubiquitin ligase called RNF166, which destabilizes angiomotins, activates YAP, and is associated with a poor prognosis in colorectal cancer patients. Mechanistically, RNF166 specifically recognizes PARsylated angiomotin, a modification mediated by tankyrase at specific amino acid residues (D506, E513, E516, and E528). The tankyrase inhibitor XAV939, effectively prevents RNF166-dependent destabilization of angiomotins and subsequent activation of YAP. Additionally, YAP-5SA, a constitutively active form of YAP, rescues colorectal cancer progression following knockdown of RNF166. Importantly, the C-terminus of RNF66, particularly the Di19-ZF domain, is the crucial region responsible for recognizing ADP-ribosylated angiomotins. Together, this work not only sheds light on the regulation of the Hippo pathway in colorectal cancer but also uncovers a novel poly(ADP-ribose)-binding domain, which may serve as a potential therapeutic target for intervention.
Theileria parasites sequester host eIF5A to escape elimination by host-mediated autophagy
Authors: Villares Marie , Lourenço Nelly , Ktorza Ivan , Berthelet Jérémy , Panagiotou Aristeidis , Richard Aurélie , Amo Angélique , Koziy Yulianna , Medjkane Souhila , Valente Sergio , Fioravanti Rossella , Pioche-Durieu Catherine , Lignière Laurent , Chevreux Guillaume , Mai Antonello , Weitzman Jonathan B. 
Published: March 2024

AbstractIntracellular pathogens develop elaborate mechanisms to survive within the hostile environments of host cells. Theileria parasites infect bovine leukocytes and cause devastating diseases in cattle in developing countries. Theileria spp. have evolved sophisticated strategies to hijack host leukocytes, inducing proliferative and invasive phenotypes characteristic of cell transformation. Intracellular Theileria parasites secrete proteins into the host cell and recruit host proteins to induce oncogenic signaling for parasite survival. It is unknown how Theileria parasites evade host cell defense mechanisms, such as autophagy, to survive within host cells. Here, we show that Theileria annulata parasites sequester the host eIF5A protein to their surface to escape elimination by autophagic processes. We identified a small-molecule compound that reduces parasite load by inducing autophagic flux in host leukocytes, thereby uncoupling Theileria parasite survival from host cell survival. We took a chemical genetics approach to show that this compound induced host autophagy mechanisms and the formation of autophagic structures via AMPK activation and the release of the host protein eIF5A which is sequestered at the parasite surface. The sequestration of host eIF5A to the parasite surface offers a strategy to escape elimination by autophagic mechanisms. These results show how intracellular pathogens can avoid host defense mechanisms and identify a new anti-Theileria drug that induces autophagy to target parasite removal.
Single-atom Mo-tailored high-entropy-alloy ultrathin nanosheets with intrinsic tensile strain enhance electrocatalysis
Authors: He Lin , Li Menggang , Qiu Longyu , Geng Shuo , Liu Yequn , Tian Fenyang , Luo Mingchuan , Liu Hu , Yu Yongsheng , Yang Weiwei , Guo Shaojun 
Published: March 2024

AbstractThe precise structural integration of single-atom and high-entropy-alloy features for energy electrocatalysis is highly appealing for energy conversion, yet remains a grand challenge. Herein, we report a class of single-atom Mo-tailored PdPtNiCuZn high-entropy-alloy nanosheets with dilute Pt-Pt ensembles and intrinsic tensile strain (Mo1-PdPtNiCuZn) as efficient electrocatalysts for enhancing the methanol oxidation reaction catalysis. The as-made Mo1-PdPtNiCuZn delivers an extraordinary mass activity of 24.55 A mgPt−1 and 11.62 A mgPd+Pt−1, along with impressive long-term durability. The planted oxophilic Mo single atoms as promoters modify the electronic structure of isolated Pt sites in the high-entropy-alloy host, suppressing the formation of CO adsorbates and steering the reaction towards the formate pathway. Meanwhile, Mo promoters and tensile strain synergistically optimize the adsorption behaviour of intermediates to achieve a more energetically favourable pathway and minimize the methanol oxidation reaction barrier. This work advances the design of atomically precise catalytic sites by creating a new paradigm of single atom-tailored high-entropy alloys, opening an encouraging pathway to the design of CO-tolerance electrocatalysts.