bluuebunny/crossref_metadata_2025_split huggingface dataset:
Healthcare staff’s perspectives on long-acting injectable buprenorphine treatment: a qualitative interview study
Authors: Nordgren Johan , Monwell Bodil , Johnson Björn , Gunnarsson Nina Veetnisha , Capusan Andrea Johansson 
Published: April 2024

Abstract
Background
Long-acting injectable buprenorphine (LAIB) formulations are a novel treatment approach in opioid agonist treatment (OAT), which provide patients with a steady dose administered weekly or monthly and thus reduce the need for frequent clinic visits. Several studies have analyzed patient experiences of LAIB but the perspective of OAT staff is unknown. This study aimed to explore how healthcare staff working in OAT clinics in Sweden perceive and manage treatment with LAIB.

Methods
Individual qualitative interviews were conducted with OAT physicians (n = 10) in tandem with nine focus group sessions with OAT nurses and other staff categories (n = 41). The data was analyzed with thematic text analysis.

Results
Five central themes were identified in the data: (1) advantages and disadvantages of LAIB, (2) patient categories that may or may not need LAIB, (3) patients’ degrees of medication choice, (4) keeping tabs, control and treatment alliance, and (5) LAIB’s impact on risk and enabling environments in OAT. Overall staff found more advantages than disadvantages with LAIB and considered that patients with ongoing substance use and low adherence were most likely to benefit from LAIB. However, less frequent visits were viewed as problematic in terms of developing a treatment alliance and being able to keep tabs on patients’ clinical status. Clinics differed regarding patients' degrees of choice in medication, which varied from limited to extensive. LAIB affected both risk and enabling environments in OAT.

Conclusions
LAIB may strengthen the enabling environment in OAT for some patients by reducing clinic visits, exposure to risk environments, and the pressure to divert medication. A continued discussion about the prerequisites and rationale for LAIB implementation is needed in policy and practice.
Who gets screened and who tests positive? Drug screening among justice-involved youth in a midwestern urban county
Authors: Clifton Richelle L. , Carson Ian , Dir Allyson L. , Tu Wanzhu , Zapolski Tamika C.B. , Aalsma Matthew C. 
Published: April 2024

Abstract
Background
Given high rates of substance use among justice-involved youth, justice systems have attempted to monitor use through drug screening (DS) procedures. However, there is discretion in deciding who is screened for substance use, as not every youth who encounters the system is screened. The aim of the current study was to examine factors associated with selection for and results of oral DS among justice-involved youth assigned to probation to better inform potential DS policy. Electronic court records from 4,668 youth with first-incident records assigned to probation in a midwestern urban county’s juvenile justice system between 2011 and 2016 were included in the analytical sample. Race/ethnicity, gender, age, number of charges and charge type for the current incident were included as independent variables.

Results
Multivariable hierarchical logistic regression analyses indicated that males were more likely to be assigned to DS (aOR = 0.40, 95%CI [0.34, 0.46]), and more likely to test positive for use (aOR = 0.43, 95% CI [0.34, 0.54]) than females. As age increased, youth were less likely to be assigned to DS (aOR = 0.91, 95% CI [0.87, 0.94]), with non-significant differences in DS results. Greater number of charges were associated with a higher likelihood of being assigned to DS (aOR = 1.55, 95% CI [1.43, 1.68]). Youth with violent offenses were more likely to be assigned to DS than those with other offense types (property offenses, drug offenses, statutory offenses, disorderly conduct, and all other offenses), but less likely to test positive for use.

Conclusions
Many factors were associated with differences in DS, but these factors were not always associated with differential DS results. Demographic or charge-based decisions may not be appropriate for DS assignment.
CNS tumors with PLAGL1-fusion: beyond ZFTA and YAP1 in the genetic spectrum of supratentorial ependymomas
Authors: Tauziède-Espariat Arnault , Nicaise Yvan , Sievers Philipp , Sahm Felix , von Deimling Andreas , Guillemot Delphine , Pierron Gaëlle , Duchesne Mathilde , Edjlali Myriam , Dangouloff-Ros Volodia , Boddaert Nathalie , Roux Alexandre , Dezamis Edouard , Hasty Lauren , Lhermitte Benoît , Hirsch Edouard , Hirsch Maria Paola Valenti , Ardellier François-Daniel , Karnoub Mélodie-Anne , Csanyi Marie , Maurage Claude-Alain , Mokhtari Karima , Bielle Franck , Rigau Valérie , Roujeau Thomas , Abad Marine , Klein Sébastien , Bernier Michèle , Horodyckid Catherine , Adam Clovis , Brandal Petter , Niehusmann Pitt , Vannod-Michel Quentin , Provost Corentin , de Champfleur Nicolas Menjot , Nichelli Lucia , Métais Alice , Mariet Cassandra , Chrétien Fabrice , Blauwblomme Thomas , Beccaria Kévin , Pallud Johan , Puget Stéphanie , Uro-Coste Emmanuelle , Varlet Pascale ,   RENOCLIP-LOC
Published: April 2024

AbstractA novel methylation class, “neuroepithelial tumor, with PLAGL1 fusion” (NET-PLAGL1), has recently been described, based on epigenetic features, as a supratentorial pediatric brain tumor with recurrent histopathological features suggesting an ependymal differentiation. Because of the recent identification of this neoplastic entity, few histopathological, radiological and clinical data are available. Herein, we present a detailed series of nine cases of PLAGL1-fused supratentorial tumors, reclassified from a series of supratentorial ependymomas, non-ZFTA/non-YAP1 fusion-positive and subependymomas of the young. This study included extensive clinical, radiological, histopathological, ultrastructural, immunohistochemical, genetic and epigenetic (DNA methylation profiling) data for characterization. An important aim of this work was to evaluate the sensitivity and specificity of a novel fluorescent in situ hybridization (FISH) targeting the PLAGL1 gene. Using histopathology, immunohistochemistry and electron microscopy, we confirmed the ependymal differentiation of this new neoplastic entity. Indeed, the cases histopathologically presented as “mixed subependymomas-ependymomas” with well-circumscribed tumors exhibiting a diffuse immunoreactivity for GFAP, without expression of Olig2 or SOX10. Ultrastructurally, they also harbored features reminiscent of ependymal differentiation, such as cilia. Different gene partners were fused with PLAGL1: FOXO1, EWSR1 and for the first time MAML2. The PLAGL1 FISH presented a 100% sensitivity and specificity according to RNA sequencing and DNA methylation profiling results. This cohort of supratentorial PLAGL1-fused tumors highlights: 1/ the ependymal cell origin of this new neoplastic entity; 2/ benefit of looking for a PLAGL1 fusion in supratentorial cases of non-ZFTA/non-YAP1 ependymomas; and 3/ the usefulness of PLAGL1 FISH.
Interpreting artificial intelligence models: a systematic review on the application of LIME and SHAP in Alzheimer’s disease detection
Authors: Vimbi Viswan , Shaffi Noushath , Mahmud Mufti 
Published: April 2024

AbstractExplainable artificial intelligence (XAI) has gained much interest in recent years for its ability to explain the complex decision-making process of machine learning (ML) and deep learning (DL) models. The Local Interpretable Model-agnostic Explanations (LIME) and Shaply Additive exPlanation (SHAP) frameworks have grown as popular interpretive tools for ML and DL models. This article provides a systematic review of the application of LIME and SHAP in interpreting the detection of Alzheimer’s disease (AD). Adhering to PRISMA and Kitchenham’s guidelines, we identified 23 relevant articles and investigated these frameworks’ prospective capabilities, benefits, and challenges in depth. The results emphasise XAI’s crucial role in strengthening the trustworthiness of AI-based AD predictions. This review aims to provide fundamental capabilities of LIME and SHAP XAI frameworks in enhancing fidelity within clinical decision support systems for AD prognosis.
Implementation of an internet-based stress management program in micro- and small-sized enterprises: a study protocol for a pre-post feasibility study of the effectiveness-implementation hybrid type 2 trial
Authors: Sasaki Natsu , Shimazu Taichi , Takeno Hajime , Ogawa Sayaka , Sawada Utako , Tsutsumi Akizumi , Imamura Kotaro 
Published: April 2024

Abstract
Background
Although internet-based stress management programs are proven effective in improving mental health among workers, micro- and small-sized enterprises (MSEs), lacking in occupational healthcare services, face challenges implementing them. To address this gap, this study will develop the program with stakeholders at MSEs to aim for real-world implementation.

Objectives
This paper describes a study protocol for a pre-post feasibility study of an effectiveness-implementation hybrid type 2 trial of text-based internet-based programs (“WellBe-LINE”) in MSEs with less than 50 employees. This feasibility study primarily aims to evaluate trial methods for future effectiveness-implementation hybrid type 2 trials.

Methods
For this study protocol, an internet- and text-based self-care intervention program using the LINE app (a popular message tool in Japan) will be prepared according to evidence-based psychoeducational topics. Based on our online survey findings, personalized algorithms will be implemented according to employees’ gender, age, and psychological distress levels. A personalized program using a popular pre-existing text app is expected to reduce employees’ burdens and be attractive to them, resulting in successful implementation outcomes and mental health benefits. A pre-post design feasibility study will be conducted on ten companies to evaluate trial methods (e.g., recruitment and procedures). The primary outcome will involve individual-level penetration, defined as the proportion of the number of employees who register for the program divided by the total number of invited employees at the company. The progression criterion to go next trial specifies that more than 50% of the recruited companies obtain 60% individual penetration, which is set based on the findings of the prior survey of employees at MSEs and of interviews of stakeholders involved in this study, and will be measured by LINE system. Finally, acceptability, appropriateness, and feasibility will be measured using internet-based questionnaires and interviews.

Discussion
This pre-post feasibility study for future effectiveness-implementation hybrid type 2 trials will provide in-depth knowledge about the successful implementation of text-based, semi-personalized, self-care mental health interventions in real-world settings using both quantitative and qualitative data.

Conclusions
This feasibility study will help validate the effectiveness of text-based interventions using a widely used social networking service (SNS) tool for employees in MSEs.

Trial registration
UMIN clinical trial registration, UMIN000046960. Registered on February 21, 2022.
https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000053570
Assessing the equivalency of face-to-face and online simulated patient interviews in an educational intervention
Authors: Regehr Cheryl , Birze Arija 
Published: April 2024

Abstract
Background
In adapting to COVID-19, many health professional training programs moved abruptly from in-person to online simulated patient interviews for teaching and evaluation without the benefit of evidence regarding the efficacy of this mode of delivery. This paper reports on a multi-methods research project comparing in-person and online simulated patient interviews conducted by allied health professionals as part of an educational intervention offered at a large university teaching hospital.

Methods
Twenty-three participants conducted two 15-min interviews with simulated patients using previously validated scenarios of patients presenting with suicide risk. In order to assess the equivalency of the two modalities, physiological and psychological stress were measured using heart rate variability parameters and the State-Trait Anxiety Inventory respectively, and then were compared across cohorts using t-tests. Reflective interviews elicited qualitative impressions of the simulations that were subject to thematic qualitative analysis.

Results
There were no statistical differences in measures of psychological stress or physiological arousal of participant health care professionals who engaged with in-person versus online simulated interviews, suggesting they were equally effective in eliciting reactions commonly found in challenging clinical situations. In reflective interviews, participants commented on the realism of both modalities of simulated patient encounters and that simulated interviews provoked emotional and physiological responses consistent with actual patient encounters.

Conclusions
These findings provide developing evidence that carefully designed online clinical simulations can be a useful tool for the education and assessment of healthcare professionals.
Multimaterial decomposition in dual-energy CT for characterization of clots from acute ischemic stroke patients
Authors: Gassenhuber Melina , Lochschmidt Maximilian E. , Hammel Johannes , Boeckh-Behrens Tobias , Ikenberg Benno , Wunderlich Silke , Liesche-Starnecker Friederike , Schlegel Jürgen , Pfeiffer Franz , Makowski Marcus R. , Zimmer Claus , Riederer Isabelle , Pfeiffer Daniela 
Published: April 2024

Abstract
Background
Nowadays, there is no method to quantitatively characterize the material composition of acute ischemic stroke thrombi prior to intervention, but dual-energy CT (DE-CT) offers imaging-based multimaterial decomposition. We retrospectively investigated the material composition of thrombi ex vivo using DE-CT with histological analysis as a reference.

Methods
Clots of 70 patients with acute ischemic stroke were extracted by mechanical thrombectomy and scanned ex vivo in formalin-filled tubes with DE-CT. Multimaterial decomposition in the three components, i.e., red blood cells (RBC), white blood cells (WBC), and fibrin/platelets (F/P), was performed and compared to histology (hematoxylin/eosin staining) as reference. Attenuation and effective Z values were assessed, and histological composition was compared to stroke etiology according to the Trial of ORG 10172 in Acute Stroke Treatment (TOAST) criteria.

Results
Histological and imaging analysis showed the following correlation coefficients for RBC (r = 0.527, p < 0.001), WBC (r = 0.305, p = 0.020), and F/P (r = 0.525, p < 0.001). RBC-rich thrombi presented higher clot attenuation in Hounsfield units than F/P-rich thrombi (51 HU versus 42 HU, p < 0.01). In histological analysis, cardioembolic clots showed less RBC (40% versus 56%, p = 0.053) and more F/P (53% versus 36%, p = 0.024), similar to cryptogenic clots containing less RBC (34% versus 56%, p = 0.006) and more F/P (58% versus 36%, p = 0.003) than non-cardioembolic strokes. No difference was assessed for the mean WBC portions in all TOAST groups.

Conclusions
DE-CT has the potential to quantitatively characterize the material composition of ischemic stroke thrombi.

Relevance statement
Using DE-CT, the composition of ischemic stroke thrombi can be determined. Knowledge of histological composition prior to intervention offers the opportunity to define personalized treatment strategies for each patient to accomplish faster recanalization and better clinical outcomes.

Key points
• Acute ischemic stroke clots present different recanalization success according to histological composition.
• Currently, no method can determine clot composition prior to intervention.
• DE-CT allows quantitative material decomposition of thrombi ex vivo in red blood cells, white blood cells, and fibrin/platelets.
• Histological clot composition differs between stroke etiology.
• Insights into the histological composition in situ offer personalized treatment strategies.

Graphical Abstract
Unveiling a century of Taraxacum officinale G.H. Weber ex Wiggers research: a scientometric analysis and thematically-based narrative review
Authors: Taha Manal Mohamed Elhassan , Abdelwahab Siddig Ibrahim 
Published: April 2024

Abstract
Background
This study aims to conduct a scientometric analysis and thematically-based narrative review of a century of Taraxacum officinale research (TOR), uncovering patterns, trends, themes, and advancements in the field to provide insights for future investigations. The study followed PRISMA guidelines and utilized the Scopus database with MeSH terms for bibliographic data retrieval. Scientometric mapping employed VOSviewer and R-package-based Bibliometrix, while extracted themes were reviewed narratively. A detailed analysis of TOR was achieved by including only original studies.

Results
The findings include the extensive duration of TOR since 1908 and its significant growth, particularly in the last two decades. China emerges as the most productive country, but the United States leads in recognizable and collaborative TOR. The thematic map displays dynamic and diverse themes, with a rich knowledge structure revealed through the analysis of term co-occurrence. The year 2016 represents a turning point in the thematic map, marked by numerical growth and thematic bifurcation. The study extracted several main research topics within the field of TOR, including germination, antioxidant activity, bioherbicide, oxidative stress, Taraxacum kok-saghyz, and heavy metals. These topics represent key areas of investigation and provide insights into the diverse aspects of research surrounding T. officinale. Additionally, emerging topics in TOR encompass toxicity, metabolomics, dandelion extract, and diabetes mellitus.

Conclusions
The study consolidated knowledge, highlighted research gaps, and provided directions for future investigations on TOR.
The awareness of treatment plans of craniosynostosis: guideline for patient and family version
Authors: Aminmansour Bahram , Fatehi Samaneh , Mokhtari Ali , Riazi Ali , Tehrani Donya Sheibani 
Published: April 2024

AbstractBackgroundFunctional and structural complexities associated with craniosynostosis present challenges for families of affected individuals. Additionally, these patients undergo childhood surgeries that significantly impact the role of the family/caregiver. Consequently, multiple therapeutic teams have provided various guidelines, with the most recent version in 2023 introducing the patient/family guide. The objective of this study was to evaluate the level of awareness among the patient’s family/caregiver regarding the treatment plan.MethodsThe descriptive-analytical study sample consisted of 117 caregivers (parents) of children diagnosed with craniosynostosis between 2013 and 2023, who were conveniently selected for participation. The self-designed questionnaire was based on the 2023 guidelines and underwent reliability and validity testing. It comprised 14 chapters derived from the literature, with a total of 55 yes/no questions.ResultsBased on the results obtained from this study, the total correct response rate is 62.3%. The highest level of respondent awareness was associated with Chapter 12, with a correct response rate of 69%. The lowest level of awareness, at 41.8%, was related to Chapter 10.ConclusionIt is better to use appropriate educational aids such as educational podcasts based on the latest guidelines for craniosynostosis to educate parents.
Testcross performance of
Striga
-resistant maize inbred lines and testers with varying levels of
Striga
reaction
Authors: Zebire Degife , Menkir Abebe , Adetimirin Victor , Mengesha Wende , Silvestro Meseka , Gedil Melaku 
Published: April 2024

Abstract

Background

Using a desirable tester is considered one method used to maximise genetic differences among test crosses derived from new inbred lines and improves the overall performance of maize. Thus, this study aimed to evaluate the potency of the tester with varying levels of resistance to
Striga hermonthica
in determining the testcross performance of the hybrids for
Striga
resistance and yield-related traits.

Method

The experiment was conducted with these test crosses and two standard checks (susceptible and tolerant) for different
Striga
resistance and agronomic traits during the 2018 cropping season in Abuja and Mokwa, Nigeria. The experiment was laid out in a 23 × 4 alpha-lattice design with two replications in each location. Field evaluation data was collected from
Striga
resistance and yield-related traits to estimate the performance of test crosses. Analysis of variance was conducted to determine the variance of the testcross performance.

Results

There were significant differences among test crosses for days to silking, days to pollen shedding, ear at harvest, ear aspect, ear per plant, grain yield,
Striga
damage rating at 8 and 10 weeks after planting (WAP), and
Striga
count at 8 and 10 WAP. Variations among test crosses were always higher than the corresponding variations due to the interaction between test crosses and the environment for all traits.

Conclusion

The inbred lines with low yield reduction crossed with different testers under
Striga
infested were recorded. These inbreds should be used to develop high-yielding hybrids and synthetics with elevated levels of
Striga
resistance to improve the maize breeding program.
Bayesian joint residual moveout and amplitude-variation-with-offset inversion
Authors: Saadallah Yanis , Buland Arild 
Published: April 2024

Residual moveout (RMO) can have a severe impact on seismic amplitude-variation-with-offset (AVO) analysis. It is, therefore, common practice to quality control and correct the processed seismic data for RMO before AVO analysis. However, a complicating factor is that AVO effects and tuning may result in up- or down-dipping events that are easily mistaken for events with RMO, e.g., AVO Class 2p response. Flattening these events will lead to an incorrect AVO estimation. We present a new Bayesian joint RMO and AVO inversion to estimate the RMO time shifts and the AVO intercept and gradient. The joint inversion corrects the seismic data based on the RMO and AVO prior models rather than explicitly assuming that the data should be flattened. The prior models will typically guide toward flat gathers but will also allow for up- and down-dipping events when these are possible within the prior model. The method is illustrated on synthetic and real seismic data. For cases wherein flat events are correct, the results are similar to sequential methods with RMO correction before AVO analysis, but in situations wherein dipping seismic reflectors may be misinterpreted as events with RMO, the joint inversion provides better results by evaluating RMO and AVO simultaneously. The inversion results include the posterior covariance matrix, which represents uncertainties for the AVO intercept and gradient, the RMO time shifts, and the correlations between these at all samples. The uncertainty of the RMO time shift varies within seismic gathers and depends on the seismic quality and how clear and well determined the seismic events are. The uncertainty of the RMO is lower for clear and continuous events but increases in the zones with weaker and noisy events. The uncertainty of the RMO time shifts has a low impact on the uncertainty of the AVO intercept but increases the uncertainty of the AVO gradient significantly.