bluuebunny/crossref_metadata_2025_split huggingface dataset:
Selective targeting of death receptor 5 circumvents resistance of MG-63 osteosarcoma cells to TRAIL-induced apoptosis
Authors: Locklin Rachel M. , Federici Ermanno , Espina Belen , Hulley Philippa A. , Russell R. Graham G. , Edwards Claire M. 
Published: December 2007

AbstractTumor necrosis factor–related apoptosis-inducing ligand (TRAIL), a tumor necrosis factor superfamily member, targets death receptors and selectively kills malignant cells while leaving normal cells unaffected. However, unlike most cancers, many osteosarcomas are resistant to TRAIL. To investigate this resistance, we characterized the response of MG-63 osteosarcoma cells and hPOB-tert osteoblast-like cells to TRAIL and agonist antibodies to death receptor 4 (DR4) and death receptor 5 (DR5). We found that MG-63 osteosarcoma cells and hPOB-tert osteoblast-like cells show no or very little response to TRAIL or a DR4 agonist, but MG-63 cells undergo apoptosis in response to a DR5 agonist. Analysis of TRAIL receptor expression showed that normal osteoblastic and osteosarcoma cells express a variety of TRAIL receptors but this does not correlate to TRAIL responsiveness. Production of the soluble decoy receptor osteoprotegerin also could not explain TRAIL resistance. We show that TRAIL activates the canonical caspase-dependent pathway, whereas treatment with cycloheximide increases the sensitivity of MG-63 cells to TRAIL and anti-DR5 and can also sensitize hPOB-tert cells to both agents. Proapoptotic and antiapoptotic protein expression does not significantly differ between MG-63 and hPOB-tert cells or change following treatment with TRAIL or anti-DR5. However, sequencing the death domain of DR4 in several osteoblast-like cells showed that MG-63 osteosarcoma cells are heterozygous for a dominant-negative mutation, which can confer TRAIL resistance. These results suggest that although the dominant-negative form of the receptor may block TRAIL-induced death, an agonist antibody to the active death receptor can override cellular defenses and thus provide a tailored approach to treat resistant osteosarcomas. [Mol Cancer Ther 2007;6(12):3219–28]
The synthetic oleanane triterpenoid, CDDO-methyl ester, is a potent antiangiogenic agent
Authors: Vannini Nicola , Lorusso Girieca , Cammarota Rosaria , Barberis Massimo , Noonan Douglas M. , Sporn Michael B. , Albini Adriana 
Published: December 2007

Abstract
We show that the synthetic oleanane triterpenoid, CDDO-methyl ester (CDDO-Me; methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate) is an effective agent for suppressing angiogenesis, both in cell culture and in vivo. The potency of CDDO-Me is particularly striking when dosed in vivo to inhibit the angiogenic effects of vascular endothelial growth factor and tumor necrosis factor-α in Matrigel sponge assays; activity is seen at i.p. doses of CDDO-Me as low as 0.003 mg/kg of body weight. If the Matrigel sponges are impregnated with CDDO-Me just before implantation in the mice, picomolar doses of CDDO-Me will suppress angiogenesis. CDDO-Me also inhibits growth of endothelial cells in monolayer cultures and suppresses neovascular morphogenesis in three-dimensional cultures, but significantly higher doses (50-200 nmol/L) are required. We also show antiangiogenic effects of CDDO-Me on xenografts of Kaposi's sarcoma cells in immunocompromised mice, using CD31 as a marker. Several known individual molecular targets of CDDO-Me and related triterpenoids that are relevant to all of these findings include nuclear factor-κB signaling, signal transducers and activators of transcription signaling, and transforming growth factor-β signaling, as well as Keap1, the endogenous inhibitor of the transcription factor Nrf2. However, the particularly potent antiangiogenic activity seen in vivo in the present experiments suggest that CDDO-Me, as an angioprevention agent, may be interacting with an entire network of molecular and cellular targets, rather than at a single molecular locus or in a single-cell type. [Mol Cancer Ther 2007;6(12):3139–46]
The naphthoquinones, vitamin K3 and its structural analogue plumbagin, are substrates of the multidrug resistance–linked ATP binding cassette drug transporter ABCG2
Authors: Shukla Suneet , Wu Chung-Pu , Nandigama Krishnamachary , Ambudkar Suresh V. 
Published: December 2007

Abstract
Vitamin K3 (menadione; 2-methyl-1,4-naphthoquinone) is a structural precursor of vitamins K1 and K2, which are essential for blood clotting. The naturally occurring structural analogue of this vitamin, plumbagin (5-hydroxy-menadione), is known to modulate cellular proliferation, apoptosis, carcinogenesis, and radioresistance. We here report that both vitamin K3 and plumbagin are substrates of the multidrug resistance–linked ATP binding cassette drug transporter, ABCG2. Vitamin K3 and plumbagin specifically inhibited the ABCG2-mediated efflux of mitoxantrone but did not have any effect on the ABCB1-mediated efflux of rhodamine 123. This inhibition of ABCG2 function was due to their interaction at the substrate-binding site(s). Vitamin K3 and plumbagin inhibited the binding of [125I]iodoarylazidoprazosin, a substrate of ABCG2, to this transporter in a concentration-dependent manner with IC50 values of 7.3 and 22.6 μmol/L, respectively, but had no effect on the binding of the photoaffinity analogue to ABCB1. Both compounds stimulated ABCG2-mediated ATP hydrolysis and also inhibited the mitoxantrone-stimulated ATPase activity of the ABCG2 transporter, but did not have any significant effect on the ATPase activity of ABCB1. In a cytotoxicity assay, ABCG2-expressing HEK cells were 2.8- and 2.3-fold resistant to plumbagin and vitamin K3, respectively, compared with the control cells, suggesting that they are substrates of this transporter. Collectively, these data show for the first time that vitamin K3 is a substrate of the ABCG2 transporter. Thus, ABCG2 may have a role in the regulation of vitamin K3 levels in the body. In addition, vitamin K3 and its structural derivative, plumbagin, could potentially be used to modulate ABCG2 function. [Mol Cancer Ther 2007;6(12):3279–86]
Internal Coordination in Complex Trade Negotiations
Authors: Altschul Carlos 
Published: December 2007

AbstractComplex trade negotiations call for elaborate internal coordination and adept negotiating actors. In successful cases, these actors develop reciprocal dependent behaviors. Recent business and trade negotiation experiences testify to the development of process mechanisms in a variety of settings that demonstrate the capacity of the negotiators' role to expand. Constraints are acknowledged, essentially, the fact that the negotiator is a mandated agent and acts within a timebound context. Still, as drivers, negotiators practice their trade creatively to promote internal coordination, restructure the context, reframe and help solve micro-negotiation conflicts, and create conditions for the observance of reciprocating behaviors. The French term endroit is used to describe the venue in which collaborative negotiation is conducted.
The Institutional Choice of Bilateralism and Multilateralism in International Trade and Taxation
Authors: Rixen Thomas , Rohlfing Ingo 
Published: December 2007

AbstractTrade relations are governed by a multilateral agreement, whereas the avoidance of double taxation rests on a network of about 2000 separate bilateral treaties. What accounts for the difference in the institutional form? Distinguishing between the bargaining and agreement stage of international cooperation, we first show that the institutional design of both regimes is more complex than commonly assumed. Both exhibit a mix of bilateral and multilateral bargaining that precedes multilateral agreement in trade and bilateral agreement in taxation. We demonstrate that in both regimes, governmental concerns for the distribution of benefits can best be achieved through bilateral bargaining. Multilateral bargaining serves to reduce the high transaction costs of bilateral bargains. Multilateral agreement in trade helps to overcome the problem of free-riding that results from a particular interaction of concerns on distribution and enforcement problems. Since no such problem exists in double tax avoidance, agreement is therefore bilateral in nature.
The Enduring Value of the Old Testament—An Interesting Quest
Authors: Clements Ronald 
Published: December 2007

AbstractThe period when the Society for Old Testament Study held its first meeting in 1917 marked a major turning point for the study of the Hebrew Bible. This rested on two factors: first, the preceding half-century had witnessed the slow, and often painful, acceptance in Christian and Jewish circles of a modern 'critical' explanation of the historical origin of its writings. Secondly, the context in which serious study of this literature was undertaken had increasingly moved out from a religious forum into that of a wider secular field of cultural and academic interests. The new methodology aimed to show that the Bible presented a worldview agreeable to modern scientific knowledge. In this setting, older, well-worn hermeneutical strategies were abandoned and replaced with new ones consonant with this aim. Prominent among these was a claim to present a historically verifiable demonstration that the Hebrew Bible/Old Testament possessed an enduring value based on its presentation of ideas of social justice, religious monotheism and universal morality. The claims to this uniqueness, however, rapidly lost credibility when fuller knowledge of the social world of antiquity became better known through archaeological and anthropological research. Such claims could be shown to depend largely on the Bible's own polemic. Nevertheless the idea of enduring value bears welcome comparison with comparable concerns to define what entitles any literary work to be regarded as a classic, and to deserve universal approval. Useful criteria can be set out but fail to command any wholly definitive acceptance. Rather, the best that can be achieved is to note those features and qualities which give to certain writings an intrinsic power to generate a continuity of interest and appeal. The history of the interpretation of the Old Testament shows that it performs well in such a context.
Israel's Baby: The Horror of Childbirth in the Biblical Prophets
Authors: Kalmanofsky Amy 
Published: December 2007

AbstractUsing verbal threats and graphic images of destruction, the biblical prophets employed a rhetoric of horror to terrify their audience. Modern theories about the genre of horror provide insight into the prophets' rhetoric. They elucidate the nature of biblical horror and the objects that provoke horror, as well as the ways texts work to elicit horror from their audience. This paper examines the image of the laboring woman within the context of the prophets' horror rhetoric. This image captures the physical and emotional experience of Israel awaiting Babylonian conquest and conveys the irony and futility of Israel's situation. The image also serves as a strategy of cross-gender identification, common in the horror genre, which asks a predominantly male audience to identify with a female character. This strategy reveals the essential elements of biblical horror—fear and shame—and uses these elements to motivate wayward Israel to repent. By identifying with the birthing woman, Israel will come to recognize its physical and emotional vulnerability, the futility and disgrace of its situation, and strive to reform.
The Pulsating Heart and Its Divine Sense Energies: Body and Touch in Abhinavagupta's Trika Śaivism
Authors: Skora Kerry Martin 
Published: December 2007

AbstractThis paper is a study of the significance of body and touch in the embodied thinking and lifeworld of the Hindu Tantric visionary Abhinavagupta (c. 975–1025 C.E.). I elucidate Abhinavagupta's embodied phenomenology of Śiva-Who-Is-Being, focusing on his multivocal metaphor of the pulsating heart and its divine sense-energies. I show that Abhinavagupta understood the central act of salvation, the recollection (vimarśa) of Being, or ultimate consciousness, as being a bodily felt process. Abhinavagupta drew on an earlier body of discourse and practice, the Kaula Trika substratum, whose pivotal ritual was that of sexual union. Thus, Abhinavagupta recovered the body and senses for consciousness in a sensuous and erotic phenomenology, so that vimarśa was understood precisely as the “body's recollection of Being,” the bodily felt awareness of the Pulsating Heart.
Soteriology of the Senses in Tibetan Buddhism
Authors: Gayley Holly 
Published: December 2007

AbstractIn Tibet, certain categories of Buddhist sacra are ascribed the power to liberate through sensory contact. No less than “buddhahood without meditation” is promised, offering an expedient means to salvation that seemingly obviates the need for a rigorous regime of ethical, contemplative, and intellectual training. This article investigates two such categories of sacra, substances that “liberate through tasting” and images that “liberate through seeing” as found in a mode of revelation particular to Tibet and culturally related areas, in which scriptures and sacred objects are reportedly embedded in the landscape as terma or “treasures” (gter ma). The author argues that charisma invested in these substances and images — through an amalgamation of relics and special means of consecration — provides the grounds for the soteriological benefits claimed as a result of sensory contact with them. The question is whether these benefits suggest a notion of grace in Tibetan Buddhism, and if so how it might contravene without contradicting the law of karma. Exploring this question sheds light on the role of the senses and the nature of Buddhist soteriology as it developed in Tibet.
A Late Medieval Syrian Pilgrimage Guide: Ibn Al-Awrānī's Al-Ishārāt Ilā Amākin Al-Ziyārāt (Guide To Pilgrimage Places)1
Authors: Meri Josef W. 
Published: December 2007

AbstractPilgrimage to the tombs of holy persons, known as ziyāra (lit. a visit, visiting) was a fundamental aspect of devotional life throughout the medieval Near East. Medieval Muslims composed pilgrimage guides reflecting their pilgrimage experiences and those of others. Such guides, known collectively as "kutub al-ziyārāt" (pilgrimage guides), meant to be employed at tombs and shrines, mention places efficacious for prayer, obtaining baraka (blessings), achieving cures, and fulfilling supplication for worldly and spiritual needs. This study looks at the first known Syrian pilgrimage guide which was composed during the sixteenth-century Ibn al-awrānīs-Ishārāt ilā Amākin al-Ziyārāt (Guide to Pilgrimage Places). It also explores the genesis of the ziyāra genre in Syria and offers a number of suggestions as to its late emergence there. This is followed by an annotated translation of the guide.
Gender and Struggle for Identity: the Moriscas in Sixteenth-Century Castile1
Authors: Hasenfeld Galia 
Published: December 2007

AbstractThe Castilian community of Arcos possessed the second largest concentration of Moriscos in the jurisdiction of the Inquisition tribunal of Cuenca, and offers an excellent case study in which to focus on women's share in the daily struggle to maintain Morisco traditional lifestyle under Christian oppression. Nearly half of the extant trials from Arcos concern women, and as such they enable a partial reconstruction of family structures, kinship relations, and women's activities as well as their social networks. The disappearance of Islamic religious and legal institutions following the forced conversion of Castilian Mudejars (Muslims living under Christian rule) may actually have created a greater opportunity for women to participate in unofficial leadership of crypto-Islamic practices. This article presents the cases of the sisters Beatriz and Maria del Sastre, who drew the attention of "old" Christian neighbors, their Morisco brethren, and eventually the Inquisition.
Timur the (Terrible/Tartar) Trope: a Case of Repositioning in Popular Literature and History'
Authors: Knobler Adam 
Published: December 2007

AbstractThis study details how the medieval Central Asian leader, Timur, looked upon by many in the Latin West as a potential savior, came to be vilified as British imperial interests moved from the Ottoman Porte to India and Central Asia. To the vast majority of those to whom his name means anything at all, it commemorates a militarist who perpetuated as many horrors in the span of twenty-four years as the last five Assyrian kings perpetrated in a hundred and twenty ... The crack-brained megalomania of [a] homicidal madman whose one idea is to impress the imagination of mankind with a sense of his military power by a hideous abuse of it ...2
The Dutch book trade, Christian Enlightenment and the national bibliography. The catalogues of Johannes van Abkoude (1703-60) and Reinier Arrenberg (1733-1812)
Authors: Van Lieburg Fred 
Published: December 2007

AbstractIn the 'genealogy' of Dutch national bibliographies there follows - after the Catalogus universalis by Broer Jansz and lists published by Johannes Janssonius van Waesberge between 1675 and 1684 - a hand-written booksellers catalogue by Pieter van der Aa in Leiden. It was copied, augmented and published in 1743 by his pupil Johannes van Abkoude. Publication was accompanied by conflicts with several rivals, like Bernardus Noordbeek in Amsterdam and Nicolaas Goetzee in Gorinchem. Van Abkoude defeated his colleagues' disputes thanks to the quality and public function of his work. It was not only intended for booksellers, but also for book lovers, especially for persons with a theological interest. Reinier Arrenberg, coming from a comparable religious lay culture, developed into a follower of the Christian but tolerant Dutch Enlightenment. Inspired by learned people and other socially involved individuals he himself promoted 'the education of the people' by composing, translating and publishing stories for young and old. His revised new edition of Van Abkoude's catalogue is characterised by the removal of all small publications, such as pamphlets, popular literature and religious or political controversial writings for the reason that they were no longer commercially important. The booksellers catalogues reflected the eighteenth-century developments of levelling up book prices and marketing copyrights. As precursors of national bibliographies the catalogues of Van Abkoude, Arrenberg and De Jong will keep their value.
Popular literature for Scherpenheuvel's pilgrims at the turn of the nineteenth century: a successful but underestimated component of P.J. Brepols's early career
Authors: Lee Bowen Karen 
Published: December 2007

AbstractP.J. Brepols (ca. 1778-1845), the founder of the Brepols publishing house, which is still active today, succeeded in establishing himself as a printer-publisher by focusing on the production of popular literature and prints and continually building up his clientele in the Netherlands. One lesser-known, but nonetheless important component of this initial publishing strategy and success are his editions pertaining to the devotion of the Virgin of Scherpenheuvel. In this article, I will focus on the popular devotional texts the Manier om godtvruchtelyk, en met profyt der zielen, te lezen het Heylig Roosen-kransken van Maria ... and Het nieuw Scherpenheuvels Trompetjen, editions of which were regularly printed by both Brepols and his contemporaries. Drawing upon an examination of extant copies of these books, as well as records of Brepols's business operations from ca. 1811 to ca. 1820, I will document the extent to which Brepols dominated the market for devotional publications for Scherpenheuvel, discuss his sales of these publications, and provide a detailed description of Brepols's editions of these texts in the concluding appendix. Although primarily a study of Brepols's publications, his approach to the printing and sale of these works offers an instructive example of how other printers in this period may have organized their operations.
S.D. Luzzatto's Approach Regarding the Unity of the Book of Isaiah
Authors: Vargon Shmuel 
Published: December 2007

AbstractIn this article we have described Luzzatto's position, as it is expressed in different passages in his essays, commentaries, and writings, regarding the unity of the book of Isaiah and regarding the question of the time of the various prophecies in the first part of the book, to which different scholars ascribed a later date, in the Second Temple period. We classified and presented the arguments of the scholars
Spirit and Voice: Toward a Feminist Pentecostal Pneumatology
Authors: Hollingsworth Andrea 
Published: December 2007

AbstractThis article suggests that bringing feminist pneumatology and Pentecostal spirituality into dialogue may provide new opportunities link women's empowerment with the doctrine of the Holy Spirit. Following a brief overview of feminist pneumatology and Pentecostal spirituality, it exposits Sarah Coakley's pneumatology, arguing that her insights lead us to inquire about the ways in which Charismatic piety might contribute to the empowerment of Pentecostal women in the majority world today. The article then highlights sociological research which shows that Latin American women's ecstatic experiences of the Spirit are frequently linked with an increased sense of personal subjectivity, and the ability to “give voice” in both public and private spheres. It concludes with a proposal for speaking of the Holy Spirit as the divine voice, suggesting that this may be one way to move toward a constructive feminist Pentecostal pneumatology.
Mary, the Unwelcome (?) Guest in Catholic/Pentecostal Dialogue
Authors: Colle Ralph Del 
Published: December 2007

AbstractCatholic Marian doctrines and practices have been a major stumbling block for Catholic/Pentecostal dialogue. In this article I utilize a pneumatological perspective to suggest that Mariology exemplifies the intersection between a Catholic theology of grace (including spirituality) and ecclesiology (embracing Vatican II's articulation of Mariology). I build on the notion that the outpouring of the Holy Spirit alerts the Pentecostal/Charismatic believer to: 1) the church's existence in the outpouring of the Holy Spirit, 2) the reception of the grace, gifts and charisms of the Holy Spirit, 3) the fraternal/sororal recognition of “anointed ones” in the midst of the Pentecostal assembly, and 4) the doxological response in which praise and veneration are appropriate in an eschatologically oriented church. In doing so I correlate each of these points with aspects of Catholic Marian doctrine and praxis and seek to elicit a Pentecostal response.