bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of national smoke-free policies with per-capita cigarette consumption and acute myocardial infarction mortality in Europe
Authors: Sassano Michele , Mariani Marco , Pastorino Roberta , Ricciardi Walter , La Vecchia Carlo , Boccia Stefania 
Published: March 2024

BackgroundEvidence on the association between smoke-free policies and per-capita cigarette consumption and mortality due to acute myocardial infarction (AMI) in Europe is limited. Hence, we aimed to assess this association and to evaluate which factors influence it.MethodsWe performed an interrupted time series analysis, including 27 member states of the European Union and the UK, on per-capita cigarette consumption and AMI mortality.A multivariate meta-regression was used to assess the potential influence of other factors on the observed associations.ResultsAround half of the smoke-free policies introduced were associated with a level or slope change, or both, of per-capita cigarette consumption and AMI mortality (17 of 35). As for cigarette consumption, the strongest level reduction was observed for the smoking ban issued in 2010 in Poland (rate ratio (RR): 0.47; 95% CI: 0.41, 0.53). Instead, the largest level reduction of AMI mortality was observed for the intervention introduced in 2012 in Bulgaria (RR: 0.38; 95% CI: 0.34, 0.42).Policies issued more recently or by countries with a lower human development index were found to be associated with a larger decrease in per-capita cigarette consumption. In addition, smoking bans applying to bars had a stronger inverse association with both cigarette consumption and AMI mortality.ConclusionsThe results of our study suggest that smoke-free policies are effective at reducing per-capita cigarette consumption and AMI mortality. It is extremely important to monitor and register data on tobacco, its prevalence and consumption to be able to tackle its health effects with concerted efforts.
Landau–Zener–Stückelberg–Majorana-like dynamics induced by tunneling of spin qubit states in a multiband two-state magnetic quantum wire
Authors: Tchouobiap S. E. Mkam , Fai L. C. 
Published: March 2024

We investigate the transfer between spin quantum bit (qubit) states and study the Landau–Zener–Stückelberg–Majorana (LZSM)-like dynamics of tunneling spin qubits in a multiband two-state magnetic quantum wire. Indeed, within the framework of an optical parabolic potential in a three-dimensional (3D) heterostructure quantum wire and under the influence of an external time-varying magnetic field, a model for a multiband two-state magnetic quantum wire is developed. Here, the external magnetic field is used to coherently manipulate and control spin qubit states. By driving the system through an avoided crossing, we consider the associated effective quantum two-level system (TLS) related to the spin qubit states in each band, driving by an external coherent magnetic field in which the related Hamiltonian is Hermitian, and which generally paves a way to LZSM interferometry. Thus, we establish the analytical expressions of the energy eigenvalues in each band and derive the analytical solution of the dynamical evolution of the tunneling probabilities of the associated TLS. Accordingly, nonadiabatic and adiabatic tunneling probabilities (survival and transition) are calculated for each band of the multiband TLS. In this respect, the nonadiabatic and adiabatic dynamical evolutions of the tunneling probabilities of spin qubit populations in the first four bands, with band quantum numbers n = 0, 1, 2 and 3 are analyzed. As a result, depending on the amplitude strength of the driven magnetic field and the magnitude of the driving frequency, we report two striking nonadiabatic and adiabatic scenarios in each band for both the diabatic and adiabatic states. In this context, driving the two states of each band of the multiband TLS related to the spin qubit states through an avoided level crossing can result in nontrivial and incoherent dynamics at certain phases, resulting to apparent inaccurate probabilities, especially in the case of strong driven magnetic field and high driving frequency.
Pelican Crow Search Optimization Enabled MIRNet-Based Image Enhancement of Histopathological Images of Uterine Tissue
Authors: Patil Veena I. , Patil Shobha R. 
Published: March 2024

The digitalized image enhancement methods offer multiple options to improve the visual quality of images. The histopathological image assessment is the golden standard to diagnose endometrial cancer, which is also called uterine cancer that seriously affects the reproductive system of females. Owing to the limited capability, complex relationship among histopathological images and its elucidation utilizing existing methods frequently fails to obtain satisfying outcomes. As a result, in this study, the Pelican crow search optimization_multiple identities representation network (PCSO_MIRNet) is presented for improving the quality of histopathology images of uterine tissue. First, the histopathological images are given to pre-processing stage, which is performed by the median filter. The image enhancement is done utilizing MIRNet, which is trained by devised PCSO. The PCSO is developed by incorporating Pelican Optimization Algorithm (POA) and Crow Search Algorithm (CSA). Furthermore, PCSO_MIRNet attained the best outcomes with a maximal peak signal-to-noise ratio (PSNR) of 44.741 dB, minimal mean squared error (MSE) of 0.937, and minimal degree of distortion (DD) value achieved is 0.068 dB.
Intel TDX Demystified: A Top-Down Approach
Authors: Cheng Pau-Chen , Ozga Wojciech , Valdez Enriquillo , Ahmed Salman , Gu Zhongshu , Jamjoom Hani , Franke Hubertus , Bottomley James 
Published: March 2024

Intel Trust Domain Extensions (TDX) is an architectural extension in the 4th Generation Intel Xeon Scalable Processor that supports confidential computing. TDX allows the deployment of virtual machines in the Secure-Arbitration Mode (SEAM) with encrypted CPU state and memory, integrity protection, and remote attestation. TDX aims at enforcing hardware-assisted isolation for virtual machines and minimize the attack surface exposed to host platforms, which are considered to be untrustworthy or adversarial in the confidential computing’s new threat model. TDX can be leveraged by regulated industries or sensitive data holders to outsource their computations and data with end-to-end protection in public cloud infrastructures.
This article aims at providing a comprehensive understanding of TDX to potential adopters, domain experts, and security researchers looking to leverage the technology for their own purposes. We adopt a top-down approach, starting with high-level security principles and moving to low-level technical details of TDX. Our analysis is based on publicly available documentation and source code, offering insights from security researchers outside of Intel.
Sleepers Led by God
Authors: Davies John A. 
Published: March 2024

Abstract
In 1 Thess 4:14 Paul has often been understood to teach that dead believers, who have been in heaven, will return to earth with Christ at the parousia. Others understand it of believers being transported to heaven. This article proposes a fresh understanding of the passage, informed by the OT and Second Temple background of God leading his people out of the realm of death and into life in his presence.
Responses of Lower-Stratospheric Water Vapor to Regional Sea Surface Temperature Changes
Authors: Zhou Lingyu , Xia Yan , Xie Fei , Zhou Chen , Zhao Chuanfeng 
Published: March 2024

Abstract
The variability of stratospheric water vapor (SWV) plays a crucial role in stratospheric chemistry and Earth’s energy budget, strongly influenced by sea surface temperature (SST). In this study, we systematically investigate the response of lower-SWV (LSWV) to regional sea surface temperature changes using idealized SST patch experiments within a climate model. The results indicate that LSWV is most sensitive to tropical sea surface temperature, with the strongest response occurring in late autumn and early winter. Warming of the tropical Indian Ocean and western Pacific (WP) leads to stratospheric drying, while warming of the tropical Atlantic (TA) and eastern Pacific results in stratospheric moistening. The drying impact on LSWV due to warming in the western Pacific Ocean exceeds the wet effect in the eastern Pacific Ocean by approximately 60%. The variations in tropical SST influence LSWV by modulating the temperature at the tropical tropopause layer, especially over the Indo-Pacific warm pool through Matsuno–Gill responses. Furthermore, the response of LSWV to tropical SST changes exhibits nonnegligible nonlinearity, which indicates the importance of nonlinearity in determining the LSWV response to global surface warming.

Significance Statement
In this study, we explore how changes in the temperature of the ocean’s surface can affect the amount of water vapor in the stratosphere, a layer of Earth’s atmosphere. Understanding this relationship is important because water vapor in the stratosphere can influence both our climate and the chemistry of the atmosphere. Using a climate model, we found that water vapor in the lower stratosphere is especially responsive to temperature changes in tropical ocean regions. Specifically, when the Indian Ocean and the western Pacific get warmer, the stratosphere tends to get drier. On the other hand, warming in the Atlantic and eastern Pacific leads to more moisture in the stratosphere. The way these changes add up is complex and not simply a sum of individual parts, especially in tropical warm pool regions. Our findings have implications for how we understand and predict the impacts of climate change on stratospheric water vapor.
Shared decision-making in palliative cancer care: A systematic review and metasynthesis
Authors: Rabben Jannicke , Vivat Bella , Fossum Mariann , Rohde Gudrun Elin 
Published: March 2024

Background: Shared decision-making is a key element of person-centred care and promoted as the favoured model in preference-sensitive decision-making. Limitations to implementation have been observed, and barriers and limitations, both generally and in the palliative setting, have been highlighted. More knowledge about the process of shared decision-making in palliative cancer care would assist in addressing these limitations. Aim: To identify and synthesise qualitative data on how people with cancer, informal carers and healthcare professionals experience and perceive shared decision-making in palliative cancer care. Design: A systematic review and metasynthesis of qualitative studies. We analysed data using inductive thematic analysis. Data sources: We searched five electronic databases (MEDLINE, EMBASE, PsycINFO, CINAHL and Scopus) from inception until June 2023, supplemented by backward searches. Results: We identified and included 23 studies, reported in 26 papers. Our analysis produced four analytical themes; (1) Overwhelming situation of ‘no choice’, (2) Processes vary depending on the timings and nature of the decisions involved, (3) Patient-physician dyad is central to decision-making, with surrounding support and (4) Level of involvement depends on interactions between individuals and systems. Conclusion: Shared decision-making in palliative cancer care is a complex process of many decisions in a challenging, multifaceted and evolving situation where equipoise and choice are limited. Implications for practice: Implementing shared decision-making in clinical practice requires (1) clarifying conceptual confusion, (2) including members of the interprofessional team in the shared decision-making process and (3) adapting the approach to the ambiguous, existential situations which arise in palliative cancer care.
Measurement invariance of the parent-reported Strengths and Difficulties Questionnaire in autistic adolescents
Authors: Turcan Chloe , Delamain Henry , Loke Asher , Pender Richard , Mandy Will , Saunders Rob 
Published: March 2024

Mental health conditions are more prevalent in autistic people than non-autistic people. The Strengths and Difficulties Questionnaire is a commonly used screening tool for emotional and behavioural difficulties in autistic children and adolescents. However, few studies have assessed the psychometric properties of the Strengths and Difficulties Questionnaire in populations of autistic people, especially measurement invariance, to examine whether the underlying latent structure is consistent across time or groups. Measurement invariance of the parent-reported Strengths and Difficulties Questionnaire in a nationally representative cohort study was examined: longitudinal invariance (autistic 11-, 14- and 17-year-olds) and group invariance (autistic and non-autistic 17-year-olds). Differential item functioning was explored in the autistic/non-autistic group analysis. The five-factor structure showed inadequate fit, especially in the autistic group; by extension, measurement invariance could not be established. Differential item functioning was observed for several conduct problems, prosocial behaviour and peer problems subscale items, as well as reverse-coded items. Poor structural validity and item-level invariance may confound findings from research within and between populations of autistic and non-autistic adolescents, as well as screening of mental health conditions in autistic adolescents. This research calls for the development and improvement of screening tools for emotional and behavioural difficulties in populations of autistic people while accounting for their heterogeneity. Lay abstract Autistic people are more likely than non-autistic people to experience mental health difficulties. The Strengths and Difficulties Questionnaire is often used to screen for these difficulties and to otherwise make important decisions about mental health treatment and research in populations of autistic people. However, this study suggests that parent-reported Strengths and Difficulties Questionnaire scores may not be useful for comparing autistic and non-autistic adolescents at 11, 14 and 17 years old, as well as screening for mental health conditions in autistic adolescents. In addition, several items may be more likely to be endorsed by parents of autistic 17-year-olds than by parents of non-autistic 17-year-olds (and vice versa), which might suggest caution is needed when comparing groups on specific items.
Lapidus Arthrodesis for Correction of Hallux Valgus Deformity: A Systematic Review and Meta-Analysis
Authors: Waehner Maximilian , Klos Kajetan , Polzer Hans , Ray Robbie , Lorchan Lewis Thomas , Waizy Hazibullah 
Published: March 2024

Background. The aim of this study was to evaluate and compare different fixation methods to achieve Tarsometatarsal joint I (TMT-1) arthrodesis in patients with hallux valgus regarding radiographic correction, complication profile, and clinical outcomes. Methods. A systematic review and meta-analysis included primary literature results of evidence level 1 to 3 studies in German and English. Inclusion and exclusion criteria were established and applied, along with parameters suitable for comparison of data. Results. 16 studies with a total of 1176 participants met the inclusion criteria for this analysis. Twelve evaluation criteria were compared among 3 fixation techniques; comprised of a screw-only, dorsomedial plating- and plantar plating cohort. There was no statistical difference in deformity correction (both intermetatarsal- and hallux valgus angle), or AOFAS score between the cohorts. The complication rate was 13% in the plantar-, 19.5% in the dorsomedial-, and 24.5% in the screw cohort. Nonunion was seen in 0.7% of participants in the plantar, 1.4% in the dorsomedial, and 5.3% in the screw group. The time until complete weightbearing correlated positively with the development of nonunion, with a coefficient of 0.376 (P = .009). Hardware removal was performed in 11.8% of patients in the dorsomedial cohort, 7.7% in the screw cohort, and 3.6% in the plantar cohort. Conclusion. Based on the results of meta-analysis of heterogeneous studies, plantar plating facilitated early weightbearing and patient mobilization compared to the other fixation methods, while carrying the lowest nonunion, hardware removal, and general complication risk. However, owing to the relatively small number of patients in the plantar plating group, more work is necessary to elucidate the benefits of plantar plating for a first tarsometatarsal joint arthrodesis. Development of complications appears to be largely dependent on the fixation model, rather than patient mobilization alone. Level of Evidence: 3
Glofitamab stimulates immune cell infiltration of CNS tumors and induces clinical responses in secondary CNS lymphoma
Authors: Godfrey James K. , Gao Lei , Shouse Geoffrey , Song Joo Y. , Pak Stacy , Lee Brian , Chen Bihong T. , Kallam Avyakta , Baird John H. , Marcucci Guido , Ghoda Lucy , Vauleon Stephanie , Danilov Alexey V. , Herrera Alex F. , Kwak Larry W. , Budde Lihua E. 
Published: March 2024

Abstract
Although CD20×CD3 bispecific antibodies are effective against systemic B-cell lymphomas, their efficacy in central nervous system (CNS) lymphoma is unknown. Here, we report the CD20×CD3 bispecific glofitamab penetrates the blood-brain barrier, stimulates immune-cell infiltration of CNS tumors, and induces clinical responses in patients with secondary CNS.
A combination of logical judging circuit and water-resistant ultrathin film PEDOT: PSS electrode for noninvasive ECG measurement
Authors: Song Kewei , Hirose Kayo , Niitsu Kioto , Sui Tsubasa , Kojima Hiroto , Fujie Toshinori , Umezu Shinjiro 
Published: March 2024

AbstractHeart disease-related deaths have increased in recent decades, with most patients dying of sudden cardiac arrest. In such instances, the effect of regular electrocardiogram (ECG) measurements is minimal. Therefore, long-term ECG monitoring has become increasingly important. In this paper, we report a non-adhesive high accuracy ECG monitoring system that can be used in various scenarios without interfering with daily activities. The ECG ultra-thin film electrode is made by water-resistant material based on poly(3,4-ethylenedioxythiophene) poly(4-styrenesulfonate) (PEDOT: PSS) electrode doped with ethylene glycol (EG) and xylitol, to improve the noise signal caused by sweat. The optimal ratio of the three ingredients of PEDOT: PSS/xylitol/EG was determined experimentally to accommodate the ECG monitoring. By using the proposed selectively closed multi-channel single-lead logic circuit, the noise of ECG signal received from the proposed film electrode can be successfully reduced during broad-area electrode measurements, thus to improve ECG measurement accuracy.
“Patchiness” in mechanical stiffness across a tumor as an early-stage marker for malignancy
Authors: Mirzakhel Zibah , Reddy Gudur Ashrith , Boman Jennifer , Manns Brianna , Veer Savannah ter , Katira Parag 
Published: March 2024

AbstractMechanical phenotyping of tumors, either at an individual cell level or tumor cell population level is gaining traction as a diagnostic tool. However, the extent of diagnostic and prognostic information that can be gained through these measurements is still unclear. In this work, we focus on the heterogeneity in mechanical properties of cells obtained from a single source such as a tissue or tumor as a potential novel biomarker. We believe that this heterogeneity is a conventionally overlooked source of information in mechanical phenotyping data. We use mechanics-based in-silico models of cell-cell interactions and cell population dynamics within 3D environments to probe how heterogeneity in cell mechanics drives tissue and tumor dynamics. Our simulations show that the initial heterogeneity in the mechanical properties of individual cells and the arrangement of these heterogenous sub-populations within the environment can dictate overall cell population dynamics and cause a shift towards the growth of malignant cell phenotypes within healthy tissue environments. The overall heterogeneity in the cellular mechanotype and their spatial distributions is quantified by a “patchiness” index, which is the ratio of the global to local heterogeneity in cell populations. We observe that there exists a threshold value of the patchiness index beyond which an overall healthy population of cells will show a steady shift towards a more malignant phenotype. Based on these results, we propose that the “patchiness” of a tumor or tissue sample, can be an early indicator for malignant transformation and cancer occurrence in benign tumors or healthy tissues. Additionally, we suggest that tissue patchiness, measured either by biochemical or biophysical markers, can become an important metric in predicting tissue health and disease likelihood just as landscape patchiness is an important metric in ecology.
Mitochondrial genome plasticity of mammalian species
Authors: Biró Bálint , Gál Zoltán , Fekete Zsófia , Klecska Eszter , Hoffmann Orsolya Ivett 
Published: March 2024

AbstractThere is an ongoing process in which mitochondrial sequences are being integrated into the nuclear genome. The importance of these sequences has already been revealed in cancer biology, forensic, phylogenetic studies and in the evolution of the eukaryotic genetic information. Human and numerous model organisms’ genomes were described from those sequences point of view. Furthermore, recent studies were published on the patterns of these nuclear localised mitochondrial sequences in different taxa.However, the results of the previously released studies are difficult to compare due to the lack of standardised methods and/or using few numbers of genomes. Therefore, in this paper our primary goal is to establish a uniform mining pipeline to explore these nuclear localised mitochondrial sequences.Our results show that the frequency of several repetitive elements is higher in the flanking regions of these sequences than expected. A machine learning model reveals that the flanking regions’ repetitive elements and different structural characteristics are highly influential during the integration process.In this paper, we introduce a general mining pipeline for all mammalian genomes. The workflow is publicly available and is believed to serve as a validated baseline for future research in this field. We confirm the widespread opinion, on - as to our current knowledge - the largest dataset, that structural circumstances and events corresponding to repetitive elements are highly significant. An accurate model has also been trained to predict these sequences and their corresponding flanking regions.