bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE TYPE OF SPORT, BUT NOT SEX, IMPACTS BODY COMPOSITION AND METABOLIC RESPONSE TO A COMPLETE WEIGHT LOSS – WEIGHT REGAIN EPISODE IN WEIGHT CYCLING ATHLETES. RESULTS FROM THE WAVE STUDY.
Authors: Bagot Sarah , RAMOS Ines , Miles-Chan Jennifer , Dulloo Abdul , Hackney Anthony C. , Boirie Yves , Duclos Martine , Thivel David , Isacco Laurie 
Published: February 2025

Athletes may engage in weight cycling —successive episodes of weight loss and weight (re)gain—for performance reasons, but risk metabolic adaptations and regaining more fat that was lost (fat overshoot). This study aimed to assess the influence of a complete weight cycling episode on body composition, thermoregulation, and metabolism in athletes, considering sex and the type of sport practiced. 48 athletes (28 males, 20 females) engaged in combat (n=23), strength (n=12), or endurance (n=13) sports were examined under 3 experimental conditions (weight maintenance, weight loss, weight (re)gain) during a weight cycling episode using their habitual strategies. Body composition (dual-energy X-ray absorptiometry), core body temperature (telemetric temperature sensor), energy expenditure and substrate oxidation at rest and during moderate exercise (indirect calorimetry), and energy intake (48h-food record) were assessed. Overall, athletes lost 4.4±2.3% body weight, 12.2±10.6% fat mass, and 2.6±2.3% fat-free mass (p<0.001). All variables returned to baseline values during the regain period, and a higher fat mass regain was observed in endurance than combat athletes (p<0.01). During weight loss, a transient increase in lipid and decrease in carbohydrate oxidation occurred at rest and during exercise (p<0.001). Energy expenditure and core body temperature remained unchanged across the 3 experimental conditions, and no specific sex effect was observed. Overall, no apparent body weight nor fat overshoot was observed in athletes after a complete weight cycling episode. Nonetheless, the greater fat mass gain in endurance, compared with combat athletes, highlights a need for further specific long-term studies in this population. Clinical Trial registration: NCT04107545
On the equivalence of Prony and Lanczos methods for Euclidean correlation functions
Authors: Ostmeyer J. , Sen A. , Urbach C. 
Published: February 2025

Abstract
We investigate the oblique Lanczos method recently put forward in Ref. [1] for analysing Euclidean correlators in lattice field theories and show that it is analytically equivalent to the well known Prony Generalised Eigenvalue Method (PGEVM). Moreover, we discuss that the signal-to-noise problem is not alleviated by either of these two methods. Still, both methods show clear advantages when compared to the standard effective mass approach.
SAFE: Secure Aggregation with Failover and Encryption
Authors: Sandholm Thomas , Mukherjee Sayandev , Huberman Bernardo 
Published: February 2025

We propose, analyze and experimentally evaluate a novel secure aggregation algorithm targeted at cross-organizational federated learning applications with a fixed set of participating learners. Our solution organizes learners in a chain and encrypts all traffic to reduce the controller of the aggregation to a mere message broker. We show that our algorithm scales better and is less resource demanding than existing solutions, while being easy to implement on constrained platforms.
With 36 nodes our method outperforms state-of-the-art secure aggregation by 70x, and 56x with and without failover, respectively.
Prediction of Repassivation Potential of 3D Pits Using the 1D Pit Approach
Authors: Georges Mariana , Assumpcao Raphael , Frankel Gerald S 
Published: February 2025

Abstract
In this study, cyclic potentiodynamic polarization (CPP) tests and one-dimensional (1D) pit tests were performed to evaluate the corrosion behavior of stainless steel 316L at different temperatures and identify the critical conditions for repassivation. Downward potential scans for 1D pit samples were performed at different potential scan rates to precisely determine the repassivation potential at different pit depths. The outputs from 1D pit experiments were used to predict repassivation potentials (E_rp) of three dimensional (3D) pits in bulk samples, assuming different pit geometries. Finally, these predictions were compared with the repassivation potentials obtained for bulk samples during CPP tests to verify the accuracy of predictions. This methodology provides a correlation between a controlled fundamental approach (1D pit tests) and a more practical and applied method (CPP tests on bulk samples, generating 3D pits). It also enhances the understanding of the variability in E_rp values obtained from the CPP technique, improving the reliability of this parameter.
Stromal KITL/SCF maintains pancreas tissue homeostasis and restrains tumor progression
Authors: Oñate M. Kathrina. , Oon Chet , Bhattacharyya Sohinee , Low Vivien , Chen Canping , Zhao Xiaofan , Arnold Frank , Yan Ziqiao , Pramod Sneha , Hang Yan , Ho Yu-Jui , Lowe Scott W. , Kim Seung K. , Xia Zheng , Sherman Mara H. 
Published: February 2025

Abstract
Components of normal tissue architecture serve as barriers to tumor progression. Inflammatory and wound-healing programs are requisite features of solid tumorigenesis, wherein alterations to immune and non-immune stromal elements enable loss of homeostasis during tumor onset. The precise mechanisms by which normal stromal cell states limit tissue plasticity and tumorigenesis, and which are lost during tumor progression, remain largely unknown. Here we show that healthy pancreatic mesenchyme expresses the paracrine signaling molecule KITL, also known as stem cell factor, and identify loss of stromal KITL during tumorigenesis as tumor-promoting. Genetic inhibition of mesenchymal KITL in the contexts of health, injury, and cancer together indicate a role for KITL signaling in maintenance of pancreas tissue architecture, such that loss of the stromal KITL pool increased tumor growth and reduced survival of tumor-bearing mice. Together, these findings implicate loss of mesenchymal KITL as a mechanism for establishing a tumor-permissive microenvironment.
LINE-1 ORF1p Mimics Viral Innate Immune Evasion Mechanisms in Pancreatic Ductal Adenocarcinoma
Authors: You Eunae , Patel Bidish K. , Rojas Alexandra S. , Sun Siyu , Danaher Patrick , Ho Natalie I. , Phillips Ildiko E. , Raabe Michael J. , Song Yuhui , Xu Katherine H. , Kocher Joshua R. , Richieri Peter M. , Shin Phoebe , Taylor Martin S. , Nieman Linda T. , Greenbaum Benjamin D. , Ting David T. 
Published: February 2025

Abstract
Repeat element viral mimicry is a common feature in pancreatic ductal adenocarcinoma (PDAC) that require mechanisms to manage this repeat “viral” load and attenuate innate immune responses. Here, we show that the LINE-1 ORF1 protein (ORF1p) in PDAC cells plays a role in shielding repeat RNAs from activating a pathogen recognition receptor (PRR)-mediated antiviral response that is independent of retrotransposition. Suppression of ORF1p using short hairpin RNA induces innate immune responses through the dsRNA sensors RIG-I and MAVS. Low ORF1p PDAC cell lines have suppressed expression of PRRs demonstrating convergent mechanisms to suppress innate immune signaling. Localization of ORF1p in processing bodies (PBs) with the dsRNA helicase MOV10 were found important for these antiviral responses. Loss of ORF1p resulted in significant growth reduction in tumorspheres and mouse xenografts with an enriched epithelial cell state, and high ORF1p expression was associated with worsened survival in a cohort of human PDAC patients.
Selective STING Activation in Intratumoral Myeloid Cells via CCR2-Directed Antibody Drug Conjugate TAK-500
Authors: Appleman Vicky A. , Matsuda Atsushi , Ganno Michelle L. , Zhang Dong Mei , Rosentrater Emily , Maldonado Lopez Angel E. , Porciuncula Angelo , Hatten Tiquella , Christensen Camilla L. , Merrigan Samantha A. , Lee Hong Myung , Lee Min Young , Wang Charlotte I. , Dong Linlin , Huang Jian , Iartchouk Natasha , Wang Jianing , Xu He , Yoneyama Tomoki , Piatkov Konstantin I. , Haridas Satyajeet , Harbison Carole E. , Gregory Richard C. , Parent Alexander , Lineberry Neil , Arendt Chris , Schalper Kurt A. , Abu-Yousif Adnan O. 
Published: February 2025

Abstract
The tumor microenvironment (TME) in solid tumors contains myeloid cells that modulate local immune activity. STING signaling activation in these myeloid cells enhances local type I interferon (IFN) production, inducing an innate immune response that mobilizes adaptive immunity and reprograms immunosuppressive myeloid populations to drive antitumor immunity. Here, we generated TAK-500, an immune cell directed antibody drug conjugate (iADC), to deliver a STING agonist to CCR2+ human cells and drive enhanced antitumor activity relative to non-targeted STING agonists. Preclinically, TAK-500 triggered dose-dependent innate immune activation in vitro. In addition, a murine TAK-500 iADC surrogate enhanced innate and adaptive immune responses both in vitro and in murine tumor models. Spatially resolved analysis of CCR2 and immune cell markers in the TME of &gt;1,000 primary human tumors showed the CCR2 protein was predominantly expressed in intratumoral myeloid cells. Collectively, these data highlight the clinical potential of delivering a STING agonist to CCR2+ cells.
Presenting Natural Continuous Speech in a Multisensory Immersive Environment Improves Speech Comprehension and Reflects the Allocation of Processing Resources in Neural Speech Tracking
Authors: Frei Vanessa , Giroud Nathalie 
Published: February 2025

Abstract
Successful speech comprehension, though seemingly effortless, involves complex interactions between sensory and cognitive processing and is predominantly embedded in a multisensory context, providing acoustic and visual speech cues. Adding the perspective of ageing, the interaction becomes even more manyfold. The impact of cognitive load on speech processing has been investigated, however, characterized by a lack of realistic speech material and multimodality. In this study, we therefore investigated the effects of memory load on naturalistic immersive audiovisual speech comprehension in older adults with varying degrees of hearing impairment and cognitive capacities. By providing natural continuous multisensory speech, provided through virtual reality, we created an immersive three-dimensional visual of the speaker and manipulated the memory load of the natural running speech inspired by a traditional n-back task. This allowed us to quantify neural speech envelope tracking via EEG and behavioral speech comprehension in varying modalities and memory loads in a highly controllable environment, while offering a realistic conversational experience. Neural speech tracking depends on an interaction between modality and memory load, moderated by auditory working memory capacity. Under low memory load, there is an increase in neural speech tracking in the immersive modality, particularly strong for individuals with low auditory working memory. Visually induced performance improvement is observed similarly in high and low memory load settings on a behavioral level. We argue that this dynamic reflects an allocation process of sensory- and cognitive processing resources depending on the presented sensory- and cognitive load of natural continuous speech and individual capacities.
Navigating Dual Identities
Authors: Minh Tran Ngoc 
Published: February 2025

Abstract
This study examines the cultural identity negotiations of young Vietnamese and second-generation Vietnamese individuals in Britain, highlighting the importance of historical and cultural awareness in navigating a dual cultural heritage. Using Hall’s cultural identity notion and Croucher and Kramer’s cultural fusion model, and a qualitative research design, the study analyses long interviews to explore how the participants’ understanding of their Vietnamese roots influences their experiences of belonging and cultural identity construction. The findings reveal that a strong connection to heritage fosters resilience, whereas a weak connection can create internal struggles in navigating a multicultural world. The study contributes to diaspora literature by emphasising the dynamic interplay between acculturation and cultural maintenance, the complexities of intergenerational identity transmission, and the role of interpersonal connection, cultural practices and internal determination in a hyperconnected world. The research bridges theoretical frameworks and empirical insights, offering ways to support second-generation immigrants in their identity formation.
Inter-State Communications before United Nations Human Rights Treaty Bodies: Distinctive Features and Evolving Aims
Authors: Garciandia Rosana 
Published: February 2025

Abstract
In 2018, the United Nations (UN) Committee on the Elimination of Racial Discrimination (CERD Committee) received its first three inter-State communications since the Convention it monitors was adopted in 1965: Palestine v Israel, Qatar v Saudi Arabia and Qatar v United Arab Emirates. These were the first inter-State cases ever initiated before this or any other UN human rights treaty body, activating a mechanism which had laid dormant for decades. In August 2024, the ad hoc conciliation commission for Palestine v Israel published its final report, marking the first time that an inter-state communication before a UN treaty body reaches its final phase. The awakening of the mechanism has inspired new lines of research, testing the mechanism in the practice of the CERD Committee and triggering analysis of its procedural features in this and other treaties. What remains underexplored is the connection between those features and the aims that States and other actors envisage for the procedure. This article explores that connection and contends that any revision of the features of the mechanism that its use may bring should be informed by its aims, which are multiple and evolving. The article proceeds in three parts. The first part analyses distinctive features of the mechanism. The second part explores the evolution in the aims of inter-State communications in connection with those features. The third part concludes by reflecting on how those connections could inform forthcoming reforms of the mechanism.
Exploring the Lived Experience of Early Taiwan Chinese Immigrants in North America
Authors: Chiang Lan-Hung Nora 
Published: February 2025

Abstract
This research focuses on those who left Taiwan for the United States and Canada, eventually planting their roots in North America. Case studies based on intensive multi-sited fieldwork conducted between 2008 and 2014 in five North American cities reveal their motivations for migration, the processes involved, and their lived experiences. They survived various challenges, such as gaining proficiency in English, adapting to different customs, enduring cold weather and overcoming loneliness. The qualitative methods used in this research gave voice to forty-two early-era Taiwan Chinese immigrants, demonstrating their roles as trailblazers for new immigrants from both Taiwan and Mainland China. A good educational background in Taiwan, further studies in the host countries, entrepreneurship, and the ability to use local resources were essential factors to help them in building successful careers. A majority settled permanently in their adopted cities, which became their homes.
Training programs in communication skills for healthcare professionals caring for children with life-limiting and life-threatening conditions and their families: A systematic review of healthcare professionals’ behavioral impact and children’s health outcomes
Authors: Yamaji Noyuri , Suzuki Daichi , Sasayama Kiriko , Nitamizu Aya , Yamamoto Mami , Ikeda Mari , Ota Erika 
Published: February 2025

Background: Effective communication has potential benefits for children, their families, and healthcare professionals. Although communication skills training programs are essential for healthcare professionals, their effects remain unclear. Aim: This review summarized existing communication skills training programs and evaluated their impact on healthcare professionals’ behavior and the health outcomes of children with life-threatening conditions and their families. Design: This systematic review was performed in accordance with the Cochrane Handbook version 6.4. Data sources: On January 21, 2024, we searched the following databases: Cochrane Central Register of Controlled Trials, PubMed, MEDLINE, Embase, PsycINFO, and CINAHL. The included studies’ risk of bias was assessed using a revised Cochrane risk-of-bias tool for randomized controlled trials 2. Owing to insufficient data and high heterogeneity, we could not perform a meta-analysis, so the findings were described narratively. Results: We identified nine studies, which included various diseases, training programs, and outcome measurement tools and timings. Among the nine studies, five of the six studies that assessed healthcare professionals’ behaviors reported that the interventions had improved them (low certainty of evidence). Only two studies reported on the quality of life and anxiety experienced by children and their families, with no clear difference between intervention and control groups. Conclusions: Communication skills training for healthcare professionals may improve their behaviors toward children with life-threatening conditions and their families. Measurement tools and timings must be standardized. Future research should develop training programs and assess their impact on children and their families, incorporating the perspective of children.
Efficacy and safety of laquinimod versus placebo in relapsing-remitting multiple sclerosis: a systematic review and meta-analysis of randomized controlled trials
Authors: Zeb Khan Malik Waleed , Ali Aizaz , Hussain Amna , Khan Safeena , Tahir Ammara , Khan Muhammad Haris , Azeem Touba , Moeez Abdul , Monis Arysha , Mian Aban Masaud , Khattak Fazia , Ali Moosa , Ikram Jibran 
Published: February 2025

Objective To investigate the safety and efficacy of laquinimod in treating relapsing-remitting multiple sclerosis (RRMS). Methods An extensive electronic search was conducted across PubMed, Embase, Cochrane Database of Systematic Reviews, and ClinicalTrials.gov to identify suitable studies. Risk of bias was assessed using Cochrane’s Risk of Bias tool. Statistical analysis was performed using RevMan 5.4.1. Results The meta-analysis of four randomized controlled trials including 3665 patients found that laquinimod significantly reduced the annualized relapse rate compared with placebo (mean difference = −0.08, 95% confidence interval [CI] = −0.12, −0.04, I2 = 0%). For disability progression confirmed at 3 months, laquinimod provided a significant advantage over placebo (hazard ratio [HR] = 0.75, 95% CI = 0.59, 0.96, I2 = 25%), whereas no benefit was achieved at 6 months (HR = 0.69, 95% CI = 0.45, 1.06, I2 = 66%). Laquinimod was also significantly better than placebo in maintaining a relapse-free status (risk ratio [RR] = 1.14 95% CI = 1.06, 1.22, I2 = 10%). Laquinimod had a comparable safety profile as placebo (RR = 1.06, 95% CI = 0.81, 1.39, I2 = 33%). Conclusions These findings support the efficacy of laquinimod in managing RRMS but necessitate careful monitoring during treatment.
Numerical simulation on the motion of bubbles and inclusion removal in the swirling long nozzle
Authors: Wang Hongjing , Zhang Lin , Li Tao , Huang Xing , He Wen , Ju Liying , Tan Min , Tang Guozhang , Wang Xiaofeng 
Published: February 2025

Abstarct Improving the removal rate of inclusions is crucial for enhancing the quality of steel products. The paper designs a swirling flow generator (SFG), which is installed between the ladle and the long nozzle, to optimize the efficiency of converting gravitational potential energy of the molten steel into swirling kinetic energy within the long nozzle. Compared the effects of the discrete phase model (DPM) and the DPM-volume of fluid (VOF) on the removal of inclusions during bubble injection, where the collision elimination behavior of inclusions and bubbles was simulated using a self-developed user-defined function (UDF), which optimizes the collision determination between bubbles and inclusions from a time point approach to a time step method, enabling full-process monitoring of bubble-inclusion collisions within discretized time steps. The results indicate that the application of the SFG significantly optimizes the flow field in the long nozzle, compared to the traditional long nozzle (TLN), the inclusion removal rate in the swirling long nozzle could be increased by approximately 50% and 20% using the DPM model and DPM-VOF coupled model, respectively.
Quantification des relations entre variables catégorielles ordinales Application aux métriques suivies par les baromètres de satisfaction
Authors: Bultez Alain , Laurent Gilles , Lemay Laurent 
Published: February 2025

Résumé Perceptions, attitudes, intentions, . . ., sont, à des fins de segmentation des marchés, de suivi ou de prévision des réactions des consommateurs, régulièrement étudiées. Ces composantes cognitives, affectives, ou comportementales, sont le plus souvent mesurées par les réponses à des questions à choix multiples : modalités prenant la forme d’un nombre limité de classes ordonnées, avec points d’ancrage, mais pas toujours toutes sémantiquement différenciées. L’analyse statistique de telles données, qualitatives, dites catégorielles ordinales, conduit généralement à les encoder numériquement et à les considérer quantitatives. Ce faisant, on leur attribue alors des propriétés dont elles ne sont pas dotées, avec pour conséquence des risques de biais. Pour les traiter correctement nous proposons une paramétrisation économétrique des relations entre de telles variables, respectant strictement leur contenu informatif. Alliant techniques de régression multinomiale cumulative et monotone, ainsi que de rééchantillonnage aléatoire, notre méthodologie permet de tester rigoureusement si des métriques de feedback de nature catégorielle ordinale pourraient être assimilées à des mesures d’intervalles. Nous l’expérimentons de manière concluante sur deux grands échantillons résultant des baromètres de satisfaction des clients de deux opérateurs de télécommunications, concurrents. Ainsi, nous montrons combien la disposition de leurs clients à les recommander s’explique par les satisfactions procurées par leurs produits-services. Subsidiairement, cette double étude de cas invalide le très populaire Net Promoter Score (NPS) censé synthétiser des distributions de degrés de vraisemblance d’une participation des consommateurs à la promotion de leurs marques favorites par bouche-à-oreille.