bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of mechanical ventilation on clinical outcomes in ICU-admitted Alzheimer’s disease patients: a retrospective cohort study
Authors: Liu Han , Liang Qun , Yang Yang , Liu Min , Zheng Boyang , Sun Shilin 
Published: March 2024

BackgroundAlzheimer’s disease (AD) is increasingly recognized as a pressing global public health issue, demanding urgent development of scientific AD management strategies. In recent years, the proportion of AD patients in Intensive Care Units (ICU) has been on the rise. Simultaneously, the use of mechanical ventilation (MV) is becoming more prevalent among this specific patient group. Considering the pathophysiological characteristics of AD, the application of MV in AD patients may lead to different outcomes. However, due to insufficient research data, the significant impact of MV on the prognosis of AD patients in the ICU remains unclear. Therefore, we conducted this study to comprehensively evaluate the potential influence of MV on the survival rate of AD patients in the ICU.MethodsWe obtained data from the MIMIC-IV database for patients diagnosed with AD. Using propensity score matching (PSM), we paired patients who received MV treatment with those who did not receive treatment. Next, we conducted Cox regression analysis to evaluate the association between MV and in-hospital mortality, 7-day mortality, 28-day mortality, 90-day mortality, 4-year mortality, length of hospital stay, and ICU stay.ResultsThe data analysis involved a cohort of 641 AD patients spanning from 2008 to 2019, inclusive. Following a 1:2 propensity score matching (PSM) procedure, 300 patients were successfully paired, comprising 123 individuals who underwent MV treatment and 177 who did not. MV demonstrated an association with an elevated risk of in-hospital mortality (HR 5.782; 95% CI 2.981–11.216; p &lt; 0.001), 7-day mortality (HR 6.353; 95% CI 3.014–13.392; p &lt; 0.001), 28-day mortality (HR 3.210; 95% CI 1.977–5.210; p &lt; 0.001), 90-day mortality (HR 2.334; 95% CI 1.537–3.544; p &lt; 0.001), and 4-year mortality (HR 1.861; 95% CI 1.370–2.527; p &lt; 0.001). Furthermore, it was associated with a prolonged length of ICU stay [3.6(2.2,5.8) vs. 2.2(1.6,3.7); p = 0.001]. In the subgroup analysis, we further confirmed the robustness of the results obtained from the overall population. Additionally, we observed a significant interaction (p-interaction &lt;0.05) between age, admission type, aspirin use, statin use, and the use of MV.ConclusionIn patients with AD who are receiving treatment in the ICU, the use of MV has been linked to higher short-term, medium-term, and long-term mortality rates, as well as prolong ICU stays. Therefore, it is crucial to break away from conventional thinking and meticulously consider both the medical condition and personal preferences of these vulnerable patients. Personalized treatment decisions, comprehensive communication between healthcare providers and patients, formulation of comprehensive treatment plans, and a focus on collaboration between the ICU and community organizations become imperative.
Remineralization and inactivation of carious lesions treated with silver fluoride in Brazilian children with special healthcare needs
Authors: Potgieter Nicoline , Pereira Viviane , Elias Roberto , Charone Senda , Groisman Sonia 
Published: March 2024

IntroductionProviding conventional, restorative dental care to children with special healthcare needs (CSHCN) often requires sedation using general anesthesia. Saliva consistency, diet, and oral hygiene practice are different for CSHCN, and limited evidence is available on the efficacy of silver fluoride (SF) for the management of carious lesions for this vulnerable population.MethodsParents of CSHCN were educated about silver fluoride as a treatment option for caries. In total, 550 carious lesions from 100 participants were identified and scored according to the Nyvad Caries criteria. A total of 100 lesions with Nyvad scores 1, 2, and 3 were treated with a single application of silver fluoride and observed postoperatively at 1, 3, and 6 weeks.ResultThe results indicate statistically significant (p &lt; 0.05) differences in lesion remineralization over the 6-week follow-up period. At the 6-week follow-up, more than 85% of all lesions were remineralized across all children, regardless of condition or original Nyvad score of 1, 2, or 3.ConclusionA single application of silver fluoride has demonstrated effectiveness in remineralization and inactivation of carious lesions over 6 weeks among Brazilian CSHCN. Silver fluoride should be considered an option for the management of carious lesions among CSHCN. Further studies are recommended, including larger sample sizes, longer follow-up times, a second application of SF, and different special needs conditions.
Medicinal plants, biodiversity, and local communities. A study of a peasant community in Venezuela
Authors: Monagas Olga , Trujillo Iselen 
Published: March 2024

ObjectiveThe main objective of this research was to record ethnobotanical data on the use and exploitation of medicinal plants, highlighting their importance for the biodiversity, culture, and tradition of a peasant community in Venezuela.Sample/methodThe study involved a population of 120 individuals, from which a sample size of 34 people was calculated using the formula for finite populations. A simple random sampling technique was employed, and all the participants were administered the TRAMIL (Traditions Medicine in Island) survey.Statistical analysisThe ethnopharmacological table was constructed, and descriptive statistics were used for analysis.ResultsA total of 116 species of medicinal plants were documented to treat various health conditions. The informants reflected through their responses that they used medicinal plants in the first instance to address a health condition, employing varied forms of plant preparation, which include decoction (65.16%), raw consumption (16.77%), maceration (8.38%), and infusion (7.09%). The most commonly used plant parts are leaves, flowers, fruits, bark, peels, roots, and bulbs, while the most commonly used botanical families are Lamiaceae, Fabaceae, Rutaceae, Malvaceae, Verbenaceae, Acanthaceae, Asteraceae, and Euphorbaceae. On the other hand, the species with the highest TRAMIL Significant Use Level were Oregano orejón (Coleus amboinicus Lour.) (68.29), Malojillo [Cymbopogon citratus (D.C.) Stapf.] (60.97), Tua (Jatropha gossypiifolia L.) (34.15), Colombiana [Kalanchoe pinnata (Lam.) Pers.] (34.15), Poleo [Micromeria brownei (Sw.) Benth.] (29.27), Pasote (Chenopodium ambrosioides L.) (29.27), Llantén (Plantago major L.) (26.83), Te negro [Phyla stoechadifolia (L.) Small] (26.83), Yerbabuena (Mentha sp.) (21.85), and Curia (Justicia pectoralis Jacq.) (21.95).ConclusionThe community of El Onoto de El Valle de Tucutunemo, Aragua State, Venezuela has a notable utilization of medicinal plant species in their instance to treat different health conditions, with the predominant focus on treating flu and stomach ailments. It is important to emphasize that all individuals approached through various data collection instruments reported using medicinal plants, both individually and within their families, spanning a wide range of ages from children to the elderly. This reflects that the use of medicinal plants is part of their cultural heritage and ancestral roots.
FORMULASI DAN ANALISIS MUTU ES KRIM BEKATUL BERAS MERAH (Oryza sativa L) DAN JAMBU KRISTAL (Psidium guajava) SEBAGAI SUMBER MAKANAN TINGGI SERAT DAN VITAMIN C BAGI ANAK SEKOLAH DASAR
Authors: Nursalma Hasna Khairunnisa , Gumilar Mulus , Judiono Judiono , Fitria Mona 
Published: March 2024

School-aged children are vulnerable to nutritional deficiencies of fiber and vitamin C because they consume less vegetables and fruit. One effort to prevent fiber and vitamin C deficiency is by making ice cream products that contain high levels of fiber and vitamin C where the additional ingredients are obtained from brown rice bran and crystal guava. The aim of this experimentation is to decide the impact of red rice bran and crystal guava formulations on the quality of ice cream products including organoleptic properties, fiber content and vitamin C levels. The research design used was experimental in nature using a one factor complete randomized design with 3 formulations of brown rice bran and guava crystals namely F1 (15%:85%), F2 (25%:75%) and F3 (35%:65%). The research method used the hedonic test to determine the organoleptic properties, enzymatic gravimetry for the fiber test and iodimetri titration for the vitamin C test. Formula F1 (15%:85%) was the best formula that met the adequacy of vitamin C and daily vitamin C for elementary school children of 20% fiber and 80% in 1 serving (80 g). The Kruskall Wallis test revealed that there was an effect of different formulations of red rice bran and crystal guava ice cream on the color, taste and overall taste of the ice cream (p<0.05). The production cost of F1 ice cream is IDR 3,000/80 g.
Elevating vehicle inspection quality through knowledge: unlocking excellence
Authors: Ilham  , Rohmani Siti 
Published: March 2024

This study analyses work performance factors, the ability to master work and work tools, and knowledge of the quality of work results of competent civil servants (PNS) in regularly inspecting motor vehicles in Indonesia. This study aims to determine knowledge as a mediating variable in the influence of work performance and the ability to master work and work tools on the quality of work results and its improvement strategy. The study's sample size was 180 people, and the total population was statistical test research using descriptive statistics with structural equation models using PLS-SEM. The study's results found that work performance and the ability to master work and tools did not directly affect the quality of work results. However, the mediation of variables of work performance knowledge and the ability to master work and work tools had a positive and significant effect on the quality of work results. Knowledge directly affects the quality of the results of work. The variables of work performance and the ability to master work and work tools directly affect understanding. Researchers suggest future research look for variable indicators of work performance, the ability to master work and tools, and learning to affect the quality of work results directly or indirectly.
ANALISIS PEMANFAATAN TEKNOLOGI INFORMASI TASPEN KEPADA PESERTA DI KANTOR PT. TASPEN (PERSERO) KANTOR CABANG KEPULAUAN NIAS
Authors: Zebua Yunus Sarofati , Ndraha Ayler Beniah , Zalukhu Yuterlin , Mendrofa Yupiter 
Published: March 2024

Abstract. Utilization of information technology is the behavior of technology employees with their duties, measurement, based on frequency of use in the diversity of applications used. Information technology is the study, design, development, implementation, support or management of computer-based information systems, especially software applications and computer hardware. Lack of use of information technology in the PT area. Taspen (Persero) Nias Islands Branch Office causes obstacles related to information, rights and obligations for Taspen participants, especially for participants who have entered the Retirement Age Limit. Because this obstacle often becomes a problem for a company, where when participants do not know their rights as Taspen participants, the company will be involved in the investigation process for Taspen participants who have obstacles or obstacles in managing their rights. This research aims to find out how information technology is used by participants at PT Taspen (Persero) Nias Islands Branch Office. Based on the research results, it was concluded that PT Taspen (Persero) Nias Islands Branch Office had taken significant steps in utilizing Information Technology (IT) to overcome the obstacles faced by retired participants, such as device non-uniformity, limited digital literacy, and electricity stability problems. However, there are still several challenges that need to be overcome. Improving participants' understanding of applications and web portals, as well as improvements in technical aspects and data security policies, is essential. Outreach and education are key in helping participants, especially older ones, understand the full benefits of IT in managing their retirement. Efforts to improve customer service with faster responses are also needed. With an ongoing commitment to increasing participants' technological understanding, improving the onboarding process, and maintaining strict data security standards, PT. Taspen (Persero) Nias Islands Branch Office can maximize the benefits of IT, provide a positive experience for participants, and maintain a high level of trust in the company.
KELIMPAHAN dan KEANEKARAGAMAN IKAN KARANG di DAERAH TERUMBU KARANG PULAU LIHAGA LIKUPANG MINAHASA UTARA
Authors: Coloay Clive Griffen , Schaduw Joshian N. W. , Kusen Janny D. , Roeroe Kakaskasen A. , Manembu Indri , Rondonuwu Ari B. 
Published: March 2024

Lihaga Island is located in West Likupang District, North Minahasa Regency. When the Likupang area has been designated as a Special Economic Zone (SEZ), and one of the five super priority tourist destinations based on Government Regulation Number 84 of 2019. This indicates that the waters of Lihaga Island will become a diving tourism destination. Data on the abundance and diversity of reef fish in these waters need to be known. The method used in this research is the Underwater Visual Census. The data obtained is then analyzed for abundance index, diversity index, uniformity index and dominance index using the Microsoft Excel program. The results show that reef fish in the waters of Lihaga Island are categorized as abundant, according to Djamali and Darsoono. (2005) with the number found > 50 individuals, dominated by the species Chromis margaritifer from the family Pomacentridae or commonly known as 'damselfishes'. The results of the analysis were based on the total number of reef fish recorded at 3 observation stations, namely the abundance index scored 1,780 ind/m2, the diversity index was in the high category with a value of H`>3.0 which was 3.15, then the uniformity index was included in the unstable category with a value <0.75. which is 0.73 and the dominance index value is categorized as low with a value of 0.10 or <0.50.
Keywords: Likupang, Lihaga Island, reef fish, underwater visual census.

ABSTRAK
Pulau Lihaga terletak di Kecamatan Likupang Barat, Kabupaten Minahasa Utara. Saat wilayah Likupang telah ditetapkan menjadi Kawasan Ekonomi Khusus (KEK), dan salah satu dari lima destinasi wisata super prioritas berdasarkan Peraturan Pemerintah Nomor 84 Tahun 2019. Mengindikasikan perairan Pulau Lihaga akan menjadi destinasi wisata selam. Data mengenai kelimpahan dan keanekaragan ikan karang di perairan ini perlu untuk diketahui. Metode yang digunakan dalam penelitan ini adalah Sensus Visual Bawah Air, Data yang didapatkan kemudian dianalisis indeks kelimpahan, indeks keanekaragaman, indeks keseragaman dan indeks dominansi menggunakan program microsoft excel.Hasil penelitian menunjukan bahwa ikan karang di perairan Pulau Lihaga dikategorikan melimpah, menurut Djamali dan Darsoono (2005) dengan jumlah yang di temukan >50 ekor yang didominasi oleh spesies Chromis margaritifer dari famili Pomacentridae atau biasa dikenal dengan nama’damselfishes’. Hasil analisis berdasarkan jumlah total ikan karang yang terdata di 3 stasiun pengangamatan yaitu Indeks kelimpahan mendapat nilai sebesar 1.780 ind/m2, Indeks keanekaragaman masuk dalam kategori tinggi dengan niali H`>3.0 yaitu 3.15, kemudian indeks keseragaman masuk dalam kategori labil dengan nilai <0.75 yaitu 0.73 dan nilai indeks dominansi yang dikategoorikan rendah dengan nilai 0.10 atau < 0,50.
Kata kunci: Likupang, Pulau Lihaga, ikan karang, sensus visual bawah air
the Teachers’Perception Toward the Use of Zoom for English Learning at Junior High School of Tellu Limpoe Sidrap
Authors: Dewi Dewi Isrianti 
Published: March 2024

Abstract
The objective of this research were: to analyze the teachers’perception on using zoom and to analyze the teachers’reaction toward the use of zoom for English learning at junior high school of tellu limpoe Sidrap.
This research used descriptive qualitative. Creswell (2013) noted that descriptive qualitative was about understanding and perspective. The subject of this research were 10 english teachers from 3 juniour high school of Tellu Limpoe Sidrap. This research applied interview guidance. It found that Teachers’perception were the zoom application made easier,fun,help the teacher in teaching English. The zoom application influenced the learning process in school,the zoom application influenced enough English skill of learners, and the zoom application made easy to use in learning English. The teachers’reaction were techers though the zoom application was recommended to use if the teachers cannot go to school for teaching,they can teach in the home,because zoom application gave more the advantages than disadvantages,the teachers supposed that bad network was the disadvantagesof zoom application,the zoom’s problems were bad net work and wastafel quota, and the last zoom application had completely item or features to use in teaching process that make easier for teacher and student.
Keyword : Zoom, Perception, Reaction, English Teacher, Learning Process from Home.
Oxidative modification products of lipids in the intraocular fluid of patients with cataracts associated with chronic non-infectious diseases
Authors: Petrenko M. A. , Borodin E. A. 
Published: March 2024

Introduction. To clarify the role of oxidative stress in the development of cataracts, it is necessary to determine the content of oxidative modification products directly in the eye tissue, but such studies are scarce, which is due to the difficulty of obtaining a sufficient amount of biomaterial for analysis and the need to use highly sensitive research methods as a result. Therefore, to assess the pathological changes in the lens, intraocular or tear fluid is used.Aim. To elucidate the role of oxidative stress in the development of cataracts by determining the content of lipid oxidation products and their comparative characteristics in intraocular fluid and in blood plasma in patients with cataracts associated with chronic non-infectious diseases.Materials and methods. The study involved 83 patients with cataracts associated with non-infectious diseases, who underwent surgical treatment. Of these, 30 patients had chronic obstructive pulmonary disease (COPD) as a comorbid condition, 45 had cardiovascular diseases (CVD), and 13 had diabetes mellitus (DM). The control group consisted of 30 practically healthy individuals without clinical signs of acute or chronic diseases. Lipid oxidation products were determined by ultraviolet spectroscopy. Absorption spectra of non-oxidized lipids (E204), diene conjugates (E233), conjugated trienes, and ketodiene (E278) were recorded. Additionally, the ratios of absorption spectra of diene conjugates to non-oxidized lipids (E233/E204), as well as conjugated dienes and ketodienes to non-oxidized lipids (E278/E204), were calculated. Tear and intraocular fluids, as well as blood plasma, served as materials for the study.Results. In the group of patients with cataracts associated with non-infectious diseases, the content of diene conjugates, conjugated trienes, and ketodienes was increased relative to similar indicators in the tear fluid of people in the control group. Moreover, more pronounced changes were observed in the group of patients with cataracts associated with COPD relative to those with CVD and DM. A comparative analysis confirmed that in the group of patients with cataracts associated with COPD, the content of oxidized lipids in intraocular fluid and in blood plasma was increased. Correlation-regression analysis showed a positive relationship between the indicators of diene conjugates in intraocular fluid and in blood plasma.Conclusions. The significant direct linear relationship between the indicators of oxidized lipids in intraocular fluid and in blood plasma in patients with cataracts and non-infectious diseases may indicate the possibility of using blood plasma for studying oxidative processes in the lens and its pathological changes for the purpose of selecting therapy and evaluating treatment efficacy. The results obtained confirm the role of oxidative stress in the development of cataracts in patients with chronic non-infectious diseases.
Características de riesgo y percepción de manifestaciones de infecciones de transmisión sexual en adolescentes.
Authors: Marca Ambrocio María Laura , Angulo Rossel Milena 
Published: March 2024

Introducción. Las Infecciones de Transmisión Sexual, constituyen un grupo de enfermedades que se adquieren fundamentalmente por contacto sexual, afectando a personas de cualquier edad, entre los cuales se encuentran los adolescentes y adultos jóvenes con conductas y actitudes sexuales riesgosas iniciación sexual en edades muy tempranas, tener más de una pareja sexual, practicar sexo en forma no segura, no usar métodos anticonceptivos de barrera. El objetivo fue determinar las características de comportamiento sexual e infecciones de transmisión sexual en estudiantes de secundaria del Complejo Educativo Integral Luz y Verdad en la gestión 2021. Metodología. El estudio fue cuantitativo, transversal y prospectivo, el universo fueron 212 estudiantes, el muestreo utilizado fue no probabilístico, para la recolección de información se utilizó un cuestionario de diez preguntas cerradas. Resultados. se reporta la participación de 48 % mujeres y 52 % varones; para el 50 % de los sujetos de información las enfermedades transmisión sexual son consideradas vergonzosas, además el 10,8 % tuvo inicio de actividad sexual antes de los 17 años, y el 9 % refiere haber tenido dos o más parejas sexuales en el último año, mientras que el 14,7 % indica alguna manifestación clínica relacionada con enfermedad de transmisión sexual y respecto a los conocimientos los estudiantes consideran tener un conocimiento regular. Discusión. Por lo tanto, el personal de salud en coordinación con el área de educación debe implementar y fortalecer la promoción y prevención de educación sexual y reproductiva.
Analisis Kepuasan Pelanggan Pada Badan Penyelenggara Jaminan Sosial (BPJS) Kesehatan Cabang Dumai
Authors: Wahyuni L , Hildawati Hildawati 
Published: March 2024

Kesehatan merupakan hal yang sangat krusial bagi masyarakat, khususnya di negara Indonesia yang memiliki tingkat populasi yang tinggi. Jaminan pemeliharaan kesehatan di Indonesia sudah berlangsung sejak zaman kolonial Belanda. Teori yang digunakan dalan penelitian ini menurut Parasurahman dalam Algifari (2016:12) yaitu : Reliability, Responsiveness, Competence, Acces, Courtesy, Communication, Credibility, Security, Understanding/Knowing the Customer, Tangibles. Teknik Pengumpulan Data diantara yaitu Observasi, Wawancara dan Kuesioner. Dalam menganalisa data, penelitian ini menggunakan analisa data statistik deskriptif, yaitu statistik yang digunakan dalam menganalisa data dengan cara mendeskripsikan atau menggambarkan data yang telah terkumpul. Kemudian pengukuran dalam penelitian ini menggunakan skala likert, yaitu suatu skala psikometrik yang umum digunakan dalam angket dan merupakan skala yang paling banyak digunakan dalam riset berupa survei. Diperoleh tanggapan responden mengenai indicator Reliability (Kehandalan) mendapatkan skor 1.256. Indikator Responsiveness (Daya Tanggap) mendapatkan skor1.298. Indikator Competence (Pengetahuan) mendapatkan skor 1.329. Indikator Acces (Akses) mendapatkan skor 1.308. Indikator Courtesy (Kesopanan) mendapatkan skor 1.291. Indikator Communication (Komunikasi) mendapatkan skor 1.274. Sedangkan indikator Credibility (Kredibilitas) mendapatkan skor 1.319, kemudian indikator Security (Keamanan) mendapatkan skor1.298 serta indikator Understanding/Knowing the Customer mendapatkan skor 1.336 dan indikator Tangibles (Bukti Fisik) mendapatkan skor 1.148. Dengan total skor keseluruhan 12.857.