bluuebunny/crossref_metadata_2025_split huggingface dataset:
Curiosity as the Thief of Wonder An Essay on Heidegger's Critique of the Ordinary Conception of Time
Authors: Stone Brad Elliott 
Published: February 2007

AbstractWhat is the connection between curiosity and the ordinary conception of time? This essay offers a reading of Heidegger's account of wonder and curiosity found in Basic Questions of Philosophy (1937-8) and attempts to show its continuity with the discussion of the now-centered ordinary conception of time in Being and Time (1927). Heidegger refutes the claim that one can still say that philosophy begins in wonder in an age that no longer understands what wonder means due to modern Da-sein's obsession with the new (curiosity). Since wonder is no longer a viable philosophical attunement, Heidegger outlines in Contributions to Philosophy (1936) a new attunement, a new key for philosophy: terror.
Effect of additional functional exercises on balance in elderly people
Authors: de Bruin Eling D , Murer Kurt 
Published: February 2007

Objective: To evaluate the additional effect of functional exercises on balance and lower extremity function among hostel-dwelling elderly people partaking in strength,training. Design: A randomized two-group parallel controlled trial. Setting: A senior resident’s hostel in Switzerland. Participants: Thirty-two individuals randomized to either strength or strength and functional exercise groups. Interventions: Both groups received machine-driven strength training for 45 min, twice weekly, for 12 weeks. The strength and functional exercises group received an additional 30 min of functional exercise training, once weekly. Main outcome measures: Tinetti test, balance tests and a physical performance test. Assessments were performed before and after the intervention. Results: Improvements for the balance test depended on the type of training (significant interaction effects [F(1,20)= 6.7; P = 0.018]). This test improved from 11.3 ∓ 11.7 to 17 ∓ 11.2 (P = 0.009) in the combined training group (n = 12) and remained from 7.3 ∓ 9.5 to 6.9 ∓ 9.2 unchanged (P = 0.821) in the strength training group (n = 13). A significant difference between groups following training was observed (P = 0.031). The Tinetti balance score and the chair stand test of the physical performance assessment improved from 14.3 ∓ 1.9 to 15.3 ∓ 1.1 (P = 0.026) and 1.8 ∓ 1.2 to 2.8 ∓ 1.1 (P = 0.012) respectively in the combined training group only. Conclusions: Our findings suggest that twice-weekly lower extremity strength training of 12 weeks’ duration in hostel-dwelling elderly people only improves task-specific balance performance and lower extremity physical function when additional functional exercises are added.
Comparative Accuracy of Magnetic Resonance Imaging and Ultrasonography in Confirming Clinically Diagnosed Patellar Tendinopathy
Authors: Warden Stuart J. , Kiss Zoltan S. , Malara Frank A. , Ooi Alistair B. T. , Cook Jill L. , Crossley Kay M. 
Published: February 2007

Background Diagnosis of patellar tendinopathy is based primarily on clinical examination; however, it is commonplace to image the patellar tendon for diagnosis confirmation, with the imaging modalities of choice being magnetic resonance imaging (MRI) and ultrasonography (US). The comparative accuracy of these modalities has not been established. Hypothesis Magnetic resonance imaging and US have good (>80%) accuracy and show substantial agreement in confirming clinically diagnosed patellar tendinopathy. Study Design Cohort study (diagnosis); Level of evidence, 2. Methods Magnetic resonance imaging and US (gray scale [GS-US] and color Doppler [CD-US]) features of 30 participants with clinically diagnosed patellar tendinopathy and 33 activity-matched, asymptomatic participants were prospectively compared. Accuracy, sensitivity, specificity, positive and negative predictive values, and the likelihood of positive and negative test results were determined for each technique. Results The accuracy of MRI, GS-US, and CD-US was 70%, 83%, and 83%, respectively (P = .04; MRI vs GS-US). The likelihood of positive MRI, GS-US, and CD-US was 3.1, 4.8, and 11.6, respectively. The MRI and GS-US had equivalent specificity (82% vs 82%; P = 1.00); however, the sensitivity of GS-US was greater than MRI (87% vs 57%; P = .01). Sensitivity (70% vs 87%; P = .06) and specificity (94% vs 82%; P = .10) did not differ between CD-US and GS-US. Conclusions Ultrasonography was more accurate than MRI in confirming clinically diagnosed patellar tendinopathy. GS-US and CD-US may represent the best combination for confirming clinically diagnosed patellar tendinopathy because GS-US had the greatest sensitivity, while a positive CD-US test result indicated a strong likelihood an individual was symptomatic.
A 10-Year Comparison of Anterior Cruciate Ligament Reconstructions with Hamstring Tendon and Patellar Tendon Autograft
Authors: Pinczewski Leo A. , Lyman Jeffrey , Salmon Lucy J. , Russell Vivianne J. , Roe Justin , Linklater James 
Published: February 2007

Background There are no controlled, prospective studies comparing the 10-year outcomes of anterior cruciate ligament (ACL) reconstruction using patellar tendon (PT) and 4-strand hamstring tendon (HT) autografts. Hypothesis Comparable results are possible with HT and PT autografts. Study Design Cohort study; Level of evidence, 2. Methods One hundred eighty ACL-deficient knees that met inclusion criteria underwent ACL reconstruction (90 HT autograft, 90 PT autograft) by one surgeon and were treated with an accelerated rehabilitation program. All knees were observed in a prospective fashion with subjective, objective, and radiographic evaluation at 2, 5, 7, and 10-year intervals. Results At 10 years, there were no differences in graft rupture rates (7/90 PT vs. 12/90 HT, P = .24). There were 20 contralateral ACL ruptures in the PT group, compared with 9 in the HT group (P = .02). In all patients, graft rupture was associated with instrumented laxity >2 mm at 2 years (P = .001). Normal or near-normal function of the knee was reported in 97% of patients in both groups. In the PT group, harvest-site symptoms (P = .001) and kneeling pain (P = .01) were more common than in the HT group. More patients reported pain with strenuous activities in PT knees than in HT knees (P = .05). Radiographic osteoarthritis was more common in PT knees than the HT-reconstructed knees (P = .04). The difference, however, was composed of patients with mild osteoarthritis. Other predictors of radiographic osteoarthritis were <90% single-legged hop test at 1 year and the need for further knee surgery. An “ideal” outcome, defined as an overall International Knee Documentation Committee grade of A or B and a radiographic grade of A at 10 years after ACL reconstruction, was associated with <3 mm of instrumented laxity at 2 years, the absence of additional surgery in the knee, and HT grafts. Conclusions It is possible to obtain excellent results with both HT and PT autografts. We recommend HT reconstructions to our patients because of decreased harvest-site symptoms and radiographic osteoarthritis.
Fampridine-SR in multiple sclerosis: a randomized, double-blind, placebo-controlled, dose-ranging study
Authors: Goodman A.D. , Cohen J.A. , Cross A. , Vollmer T. , Rizzo M. , Cohen R. , Marinucci L. , Blight A.R. 
Published: February 2007

Objective To determine the safety of sustained-release 4-aminopyridine in subjects with mutiple sclerosis (MS) and to examine dose-related efficacy up to 40 mg twice daily. Method Multicenter, randomized, double-blind, placebo-controlled, study. Following a 4-week baseline peroid, subjects were randomly assigned to receive Fampridine-SR (n=25, doses from 10 to 40 mg twice daily, increasing in 5 mg increments weekly) or placebo (n=11). A battery of assessments was performed weekly, including the MS Functional Composite (MSFC), fatigue questionnaires, and lower extremity manual muscle testing. Results The most common adverse events were dizziness, insomnia, paresthesia, asthenia, nausea, headache, and tremor. Five subjects were discontinued from Fampridine-SR because of adverse events at doses greater than 25 mg, and these included convulsions in two subjects at doses of 30 and 35 mg twice daily. Improvement were seen in lower extremity muscle strength (prospective analysis) and walking speed (post-hoc analysis) in the Fampridine-SR group compared to placebo (unadjusted p-values of 0.01 and 0.03, respectively). There were no significant differences in other MSFC measure or fatigue scores. Conclusions Future studies should employ doses up to 20 mg twice daily with lower extremity strength and walking speed as potential outcome measures. Multiple Sclerosis 2007; 13: 357-368. http://msj.sagepub.com
Detecting cardiac involvement in sarcoidosis: a call for prospective studies of newer imaging techniques
Authors: Pandya C. , Brunken R. C. , Tchou P. , Schoenhagen P. , Culver D. A. 
Published: February 2007

Diagnosis of cardiac involvement in sarcoidosis is challenging and usually relies on a combination of clinical findings and imaging abnormalities.The case of a 53-yr-old female is described who presented with ventricular tachycardia and suspected angiosarcoma involving the right atrium and superior vena cava.A combination of magnetic resonance imaging and18F-2-fluoro-2-deoxyglucose-positron emission tomography were essential to the diagnosis of cardiac sarcoidosis.Reversibility of the disease was predicted more clearly by18F-2-fluoro-2-deoxyglucose-positron emission tomography than by magnetic resonance imaging, and clinical activity was predicted by persistent hypermetabolism on serial18F-2-fluoro-2-deoxyglucose-positron emission tomography.
Increased Oxidative Stress in Prepubertal Children Born Small for Gestational Age
Authors: Mohn Angelika , Chiavaroli Valentina , Cerruto Marina , Blasetti Annalisa , Giannini Cosimo , Bucciarelli Tonino , Chiarelli Francesco 
Published: February 2007

AbstractContext: Low birth weight is associated with an increased risk of metabolic and cardiovascular diseases in adulthood. The development of insulin resistance (IR) seems to play a pivotal role; no data on the oxidant-antioxidant status are available in this risk group.Objective: This study is an assessment of oxidant-antioxidant status in prepubertal children born small for gestational age (SGA) in comparison to healthy controls and the relationship to IR.Design: This cross-sectional study compares indexes of IR and oxidant-antioxidant status in three different groups (SGA+, SGA−, controls), with analysis by post hoc and Pearson correlation.Setting: The study was conducted in the Academic Department of Pediatrics.Participants: A total of 19 SGA+ and 16 SGA− children were compared with 13 controls.Intervention: No intervention was used.Main Outcome Measures: Indexes of IR (glucose to insulin ratio, homeostasis model assessment of IR) were evaluated, and markers of oxidative stress (lag phase, malonildialdehyde, vitamin E) were measured.Results: Homeostasis model assessment of IR was significantly higher in SGA+ than SGA− children (1.32 ± 0.9 vs. 0.69 ± 0.47; P = 0.03) and controls (0.71 ± 0.37; P = 0.04). Glucose to insulin ratio was significantly lower in SGA+ than SGA− children (12.41 ± 5.01 vs. 26.54 ± 17.18; P = 0.02) and controls (26.96 ± 20.70; P = 0.04). Lag phase was significantly shorter in SGA+ than SGA− children (24.3 ± 4.38 vs. 35.59 ± 11.29 min; P = 0.003) and controls (45.28 ± 7.69 min; P = 0.0001) and in SGA− than controls (P = 0.01). Malonildialdehyde was significantly higher in SGA+ than SGA− children (0.79 ± 0.3 vs. 0.6 ± 0.1 nmol/mg; P = 0.03) and controls (0.36 ± 0.04 nmol/mg; P = 0.0001) and in SGA− children than controls (P = 0.02). Vitamin E was significantly reduced in SGA+ children than controls (27.54 ± 7.9 vs. 43.23 ± 11.32 μmol/liter; P = 0.002).Conclusion: Oxidative stress is present in both SGA+ and SGA− children, with a continuous alteration in relation to IR. Therefore, catch-up growth might exert the greatest influence in the development of future diseases.
A Familial Insulin-Like Growth Factor-I Receptor Mutant Leads to Short Stature: Clinical and Biochemical Characterization
Authors: Inagaki Kenjiro , Tiulpakov Anatoly , Rubtsov Petr , Sverdlova Polina , Peterkova Valentina , Yakar Shoshana , Terekhov Sergei , LeRoith Derek 
Published: February 2007

AbstractContext: IGF-I/IGF-I receptor (IGF-IR) signaling pathways play important roles in longitudinal growth. A novel Arg481Glu (R481Q) mutation in IGF-IR was detected in a family with intrauterine and postnatal growth retardation.Objective: The objective of the study was to explore the mechanism whereby the R481Q mutation may be causative in growth retardation.Patients: A 13-yr-old girl with short stature was studied for functional analysis of the R481Q mutation in the IGF-IR.Results: Two members of a family who showed intrauterine and postnatal growth retardation, with increased serum IGF-I levels, demonstrated a substitution of arginine for glutamine at 481 (R481Q) in the IGF-IR. This mutation results in the formation of an altered fibronectin type III domain within the α-subunit. NIH-3T3 fibroblasts that overexpress the human wild-type or R481Q mutant IGF-IR demonstrated normal cell surface ligand binding by 125I-IGF-I binding assay. However, the fold increase of IGF-I stimulated tyrosine phosphorylation of the IGF-IR β-subunit as well as downstream activation of ERK1/2 and Akt was reduced in cells overexpressing the mutant receptor. Additionally, basal and IGF-I-stimulated levels of cell proliferation were also reduced in cells overexpressing the mutant receptor.Conclusion: Our results demonstrate that NIH-3T3 cells overexpressing a mutant form of the Igf1r gene, in which arginine at 481 is substituted by glutamine, lead to reduced levels of the fold increase of IGF-IR β-subunit phosphorylation as well as ERK1/2 and Akt phosphorylation and was accompanied by decreased cell proliferation. These results are postulated to be the cause of intrauterine and postnatal growth retardation in the described patients.
Proposed Relationship Between Intravenous Immunoglobulin and Thrombosis in Renal Transplant Recipients
Authors: Duronio Antoinette , Bajjoka Iman , Hsaiky Lama , Parasuraman Ravi 
Published: February 2007

Objective: To report 2 cases of intravenous human immunoglobulin (IVIG)–associated thrombosis in kidney transplant patients. Case Summary: Both cases involved female patients presenting to Henry Ford Hospital in Detroit for renal transplantation. Patient 1 presented with systemic lupus erythematosus, positive for both anticardiolipin and anti-DNA antibody. Patient 2, post nephrectomy, was found to have moderate hyperhomocysteinemia, with a total plasma homocysteine level of 3.9 mg/L. Both patients were considered highly sensitized and at high risk for rejection due to the presence of either high panel reactive antibody or a positive B cell flow cytometry crossmatch, in addition to other risk factors. Therefore, IVIG was considered a viable treatment option to be included in induction therapy. IVIG was administered both peri- and postoperatively, and both patients experienced immediate graft function with good urine output. Within 24 hours following transplantation, elevations in serum creatinine and decreases in urine output were seen. Subsequently, kidney exploration was performed and palpable thrombi in renal arteries and veins were detected. Immediate nephrectomy was performed in both cases. Discussion: Currently, evidence derived from case reports highlights numerous risk factors for IVIG-associated thrombosis, one of which appears to be a hypercoagulable state. It has also been reported that some IVIG products contain amounts of anticardiolipin antibodies; these antibodies may potentiate thrombosis in the presence of hypercoagulable states, such as hyperhomocysteinemia or antiphospholipid syndrome, in these 2 patients, the Naranjo probability scale indicated that there was a possible association between the thrombotic events and the use of IVIG. Conclusions: Prospective trials evaluating the safety of IVIG in highly sensitized transplant patients are scarce. Therefore, it is imperative that the benefits and risks be weighed when considering the use of IVIG in highly sensitized transplant patients.
Elizabeth Pickering: The First Woman to Print Law Books in England and Relations Within the Community of Tudor London's Printers and Lawyers
Authors: Kreps Barbara 
Published: February 2007

AbstractElizabeth Pickering took over Robert Redman's press when he died in 1540, thus becoming the first woman known to print books in England. Her books tell us simply that she was Redman's widow. Wills and other legal documents in the London archives permit us to know much more. The documents examined here illuminate aspects of her personal life, but also reveal connections between a group of law-printers and lawyers that appear to have influenced the printing of law books in Tudor London. The first part of the essay traces this microhistory of family and community relations. The second half examines the books Elizabeth Pickering published.
From Bharata Natyam to Bop: Jack Cole's “Modern” Jazz Dance
Authors: Hill Constance Valis 
Published: February 2007

It's what we used to see in the dance halls in the twenties and thirties, that is what real jazz dance is. This was a group of kids who did all those dances that were in then: the Camel Walk, the Charleston, the Lindy Hop…all stemming from African dance and all filled with authentic feeling. And the root of all these elaborations was the Lindy. Whatever is danced in the name of jazz dancing must come from the Lindy, necessarily theatricalized and broadened for the stage, of course.—Jack Cole, “It's Gone Silly,” 19631947 was the year Jack Cole created Sing, Sing, Sing to the recording made famous by “King of Swing” Benny Goodman and his Big Band. “[We] kicked, spun, slammed and slid on our knees for seven minutes in true Jack Cole style,” said Rod Alexander about the dance performed by the Jack Cole Dancers when it premiered in New York at the Latin Quarter (Loney 1984, 85). “Everyone came off the floor, gasped, and threw up. It was a ball-breaker, a number that asked the impossible,” remembered Buzz Miller (Miller 1992). Described by critics as “a dance in the style of Harlem” (Martin 1947) and “a primitive dance of primitive ecstasy” (Terry 1947b), Sing, Sing, Sing was a stylized Lindy Hop, or jitterbug, that popular swing-era social dance that flung and flipped partners into “breakaway” solos and daring “air” steps. More than a step, the jitterbug was a style, a state of mind: a violent, even frenzied athleticism made it hazardous, exciting, sexual, cathartic; the jitterbugger became synonymous with the “hepcat,” a swing addict. Sing, Sing, Sing, however, was not a pat reproduction of the jitterbug. Cole had captured and distilled its energetic spirit. He codified its movement, disciplined its form, tamed and readied it for the stage.
Visually Mapping the “Nation”: Swadeshi Politics in Nationalist India, 1920–1930
Authors: Trivedi Lisa N. 
Published: February 2007

In the early years of mass nationalism in colonial South Asia, Mohandas Gandhi inaugurated aswadeshi(indigenous goods) movement, which aimed to achieveswaraj, or “home rule,” by establishing India's economic self-sufficiency from Britain. Invoking an earlier movement of the same name, Gandhi created a new form of swadeshi politics that encouraged the production and exclusive consumption of hand-spun, hand-woven cloth calledkhadi. The campaign to popularize this movement took many forms, including the organization of exhibitions that demonstrated cloth production and sold khadi goods. On the occasion of one such exhibition in 1927, Gandhi explained the significance of exhibitions for the movement:[The exhibition] is designed to be really a study for those who want to understand what thiskhadimovement stands for, and what it has been able to do. It is not a mere ocular demonstration to be dismissed out of our minds immediately. … It is not a cinema. It is actually a nursery where a student, a lover of humanity, a lover of his own country may come and see things for himself.(“The Exhibition,”Young India, 14 July 1927)
The taxonomic value of fruit structure in the subfamily Saniculoideae and related African genera (Apiaceae)
Authors: Liu Mei (Rebecca) , van Wyk Ben-Erik , Tilney Patricia M. 
Published: February 2007

AbstractAll members of Saniculoideae sensu stricto are unique in their fruit structure, having the endocarp non­lignified, outgrowths on mericarps, usually prominent intrajugal secretory ducts, vallecular vittae totally absent, commissural vittae absent except in Lagoecia L. (which should be better placed in Apioideae), carpophore absent except in Alepidea F. Delaroche, and crystals dispersed throughout the mesocarp. The fruits of the African genus Lichtensteinia Cham. & Schltdl. are very similar to those of Saniculoideae, having very prominent intrajugal secretory ducts and lacking both vallecular and commissural vittae (the endocarp of one mericarp is lignified, the other not). Furthermore, scattered crystals are present in the mesocarp. Three other African genera (Arctopus L., Polemanniopsis B.L. Burtt and Steganotaenia Hochst.) also have some fruit characters that are similar to those of Saniculoideae, such as the total absence of vallecular and commissural vittae, combined with intrajugal cavities (which are enormous in the latter two genera). They differ in some respects, such as nearly always having lignified endocarps, non­functional intrajugal secretory ducts forming cavities, wings (in Polemanniopsis and Steganotaenia), and an absence of crystals. A cladistic analysis based on all anatomical characters shows that Lichtensteinia, Polemanniopsis and Steganotaenia are directly basal to the Saniculoideae, and that there is sufficient morphological evidence (in support of earlier molecular systematic studies) to expand the circumscription of the subfamily to include these genera.
Morphology, basiphyte range, and plastid DNA phylogeny of Campylaephora borealis stat. nov. (Ceramiaceae, Rhodophyta)
Authors: Seo Kyung Suk , Cho Tae Oh , Park Ji Sun , Yang Eun Chan , Yoon Hwan Su , Boo Sung Min 
Published: February 2007

AbstractThe ceramiaceous red algal genus Campylaephora J. Agardh includes three species that occur exclusively in the northwest Pacific Ocean. We studied the morphology, basiphyte range, and molecular phylogeny of Campylaephora borealis, considered a variety of the C. crassa complex, using material collected over its geographic range. Samples of C. borealis, C. crassa, C. hypnaeoides, and putative relatives were taken from 43 locations in Korea, Japan, and Far–East Russia, including the type localities of the first two of these species. Campylaephora borealis is distinguished by proliferous branchlets on all sides of the main branches and an alternate branching pattern. It is characteristically epiphytic on diverse plants, such as Prionitis divaricata, and occurs mostly in exposed sites. It is distributed from Maengbang, Korea to Nakhodka, Far–East Russia. Based on pairwise divergences of the plastid RuBisCo spacer region and psbA sequences, C. borealis is more closely related to C. hypnaeoides than to C. crassa. The topology of the tree constructed using the combined data shows the monophyly of C. borealis, which is clearly separated from other Campylaephora species and putative relatives. Our molecular data together with the basiphyte range and a morphological reappraisal point to the independent taxonomic position of C. borealis, isolated from Campylaephora crassa. Therefore, we propose to raise Campylaephora crassa f. borealis to the rank of species: Campylaephora borealis (Nakamura) Seo et al., stat. nov. The phylogeny of Campylaephora is also discussed.