bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE KINETICS AND THE MECHANISMS OF SOME PHOTOCHEMICAL REACTIONS OF FLUORINE ATOMS AND FLUORINE‐CONTAINING RADICALS
Authors: SCHUMACHER H. J. 
Published: January 2008

Abstract— The mechanisms of these reactions were established and the kinetic parameters of their partial reactions determined:
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RESUMENSe establecieron los mecanismos de las reacciones presentadas a continuación, además de determinarse los parámetros cinéticos de sus reacciones parciales.
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Interview with Konstantinos Chorianopoulos
Authors: Lee Newton , Chorianopoulos Konstantinos 
Published: January 2008

Konstantinos Chorianopoulos is an European Community (EC) Marie Curie Fellow at the Department of Architecture at the Bauhaus University of Weimar. Konstantinos is also an Adjunct Lecturer at the Department of Product and Systems Design Engineering at the University of the Aegean. He has participated in many EC-funded research projects in the field of human-computer interaction for information, communication and entertainment applications in TV, mobile, and situated computing devices. He is the founder of UITV.INFO, a newsletter and web portal for interactive television research resources (papers, theses), news and events. In the video interview, you will hear Konstantinos' answers to the following questions:
1. What is interactive TV?
2. What is the role of ITV in learning and entertainment?
3. What is one of the most successful applications of ITV so far?
4. What are some of the major research areas in ITV?
5. How do you envision the future growth of ITV?
Homologous Recombination Is the Principal Pathway for the Repair of DNA Damage Induced by Tirapazamine in Mammalian Cells
Authors: Evans James W. , Chernikova Sophia B. , Kachnic Lisa A. , Banath Judit P. , Sordet Olivier , Delahoussaye Yvette M. , Treszezamsky Alejandro , Chon Brian H. , Feng Zhihui , Gu Yongchuan , Wilson William R. , Pommier Yves , Olive Peggy L. , Powell Simon N. , Brown J. Martin 
Published: January 2008

Abstract
Tirapazamine (3-amino-1,2,4-benzotriazine-1,4-dioxide) is a promising hypoxia-selective cytotoxin that has shown significant activity in advanced clinical trials in combination with radiotherapy and cisplatin. The current study aimed to advance our understanding of tirapazamine-induced lesions and the pathways involved in their repair. We show that homologous recombination plays a critical role in repair of tirapazamine-induced damage because cells defective in homologous recombination proteins XRCC2, XRCC3, Rad51D, BRCA1, or BRCA2 are particularly sensitive to tirapazamine. Consistent with the involvement of homologous recombination repair, we observed extensive sister chromatid exchanges after treatment with tirapazamine. We also show that the nonhomologous end-joining pathway, which predominantly deals with frank double-strand breaks (DSB), is not involved in the repair of tirapazamine-induced DSBs. In addition, we show that tirapazamine preferentially kills mutants both with defects in XPF/ERCC1 (but not in other nucleotide excision repair factors) and with defects in base excision repair. Tirapazamine also induces DNA-protein cross-links, which include stable DNA-topoisomerase I cleavable complexes. We further show that γH2AX, an indicator of DNA DSBs, is induced preferentially in cells in the S phase of the cell cycle. These observations lead us to an overall model of tirapazamine damage in which DNA single-strand breaks, base damage, and DNA-protein cross-links (including topoisomerase I and II cleavable complexes) produce stalling and collapse of replication forks, the resolution of which results in DSB intermediates, requiring homologous recombination and XPF/ERCC1 for their repair. [Cancer Res 2008;68(1):257–65]
Fludarabine, Cyclophosphamide, and Mitoxantrone as Initial Therapy of Chronic Lymphocytic Leukemia: High Response Rate and Disease Eradication
Authors: Bosch Francesc , Ferrer Ana , Villamor Neus , González Marcos , Briones Javier , González-Barca Eva , Abella Eugenia , Gardella Santiago , Escoda Lourdes , Pérez-Ceballos Elena , Asensi Antoni , Sayas Ma José , Font Llorenç , Altés Albert , Muntañola Ana , Bertazzoni Paola , Rozman María , Aymerich Marta , Giné Eva , Montserrat Emili 
Published: January 2008

Abstract
Purpose: Fludarabine, cyclophosphamide, and mitoxantrone (FCM) results in a high response rate in previously treated patients with chronic lymphocytic leukemia (CLL). The aim of this study was to investigate FCM as frontline therapy in CLL.
Experimental Design: Sixty-nine patients under the age of 65 years with active CLL were treated. Patients received six cycles of fludarabine 25 mg/m2 i.v. × 3 days, cyclophosphamide 200 mg/m2 i.v. × 3 days, and mitoxantrone 6 mg/m2 i.v. × 1 day. Treatment outcome was correlated with clinical and biological variables. The clinical significance of eradicating minimal residual disease (MRD) was also analyzed.
Results: The overall response, MRD-negative complete response (CR), MRD-positive CR, nodular partial response (PR), and PR rates were 90%, 26%, 38%, 14%, and 12%, respectively. Severe (grades 3 or 4) neutropenia developed in 10% of the patients. Major and minor infections were reported in 1% and 8% of cases, respectively. Median response duration was 37 months. Patients with del(17p) failed to attain CR. Patients achieving MRD-negative CR had a longer response duration and overall survival than patients with an inferior response. Low serum lactate dehydrogenase levels, low ZAP-70 expression, and mutated IgVH genes predicted longer response duration. Finally, both low ZAP-70 and CD38 expression in leukemic cells correlated with MRD-negativity achievement.
Conclusion: FCM induces a high response rate, including MRD-negative CRs in untreated patients with active CLL. Treatment toxicity is acceptable. Both high ZAP-70 and increased CD38 expression predict failure to obtain MRD-negative response. Patients in whom MRD can be eradicated have longer response duration and overall survival than those with inferior response. These results indicate that FCM can be an ideal companion for chemoimmunotherapy of patients with CLL.
Node-Negative Colorectal Cancer at High Risk of Distant Metastasis Identified by Combined Analysis of Lymph Node Status, Vascular Invasion, and Raf-1 Kinase Inhibitor Protein Expression
Authors: Zlobec Inti , Baker Kristi , Minoo Parham , Jass Jeremy R. , Terracciano Luigi , Lugli Alessandro 
Published: January 2008

Abstract
Purpose: To identify independent clinicopathologic factors and protein markers leading to the identification of colorectal cancer (CRC) patients with mismatch repair proficiency at risk of developing metastasis and, consequently, more likely to benefit from combined modality therapy.
Experimental Design: Immunohistochemistry for 22 tumor markers was done using a tissue microarray. A subset of 387 CRC patients with complete clinicopathologic data and TNM stage was analyzed. Univariate and multivariate analyses were done to identify independent predictive markers of metastasis. The results were validated on 810 CRC patients.
Results: In univariate analysis, T stage (P &lt; 0.001), N stage (P &lt; 0.001), tumor grade (P = 0.005), vascular invasion (P &lt; 0.001), tumor budding (P &lt; 0.001), positive expression of β-catenin (P = 0.015), overexpression of RHAMM (P = 0.008), negative expression of Raf-1 kinase inhibitor protein (RKIP; P = 0.001), and absence of intraepithelial lymphocytes (P = 0.017) were significantly associated with the presence of distant metastasis. In multivariate analysis, higher N stage (P &lt; 0.001), presence of vascular invasion (P = 0.009), and RKIP loss (P = 0.003) independently predicted distant metastatic disease. A subgroup of node-negative patients was identified as high risk for distant metastasis and showed a similar probability of metastatic risk and nearly identical survival times as node-positive patients with absence of vascular invasion and positive RKIP expression (metastatic risk, 24% and 22%; median survival time, 45.0 and 47.0 months, respectively).
Conclusion: The combined analysis of N stage, vascular invasion, and RKIP expression is highly predictive of distant metastasis in patients with mismatch repair–proficient CRC. Additionally, a subgroup of more aggressive N0 tumors can be identified by evaluating vascular invasion and RKIP expression.
Symptoms and coping in Sri Lanka 20–21 months after the 2004 tsunami
Authors: Hollifield Michael , Hewage Chandanie , Gunawardena Charlotte N. , Kodituwakku Piyadasa , Bopagoda Kalum , Weerarathnege Krishantha ,   International Post-Tsunami Study Group
Published: January 2008

BackgroundThe estimated prevalence of clinically significant psychiatric and somatic symptoms in adults >1 year after the 2004 Asian tsunami is unknown.AimsTo estimate the prevalence of psychiatric and somatic symptoms and impairment in Sri Lanka 20–21 months after the 2004 Asian tsunami, and to assess coping strategies used by tsunami-affected individuals that contribute to post-tsunami adjustment.MethodHomes from one severely affected area were randomly selected, and adult respondents were sampled utilising a modified Kish method. Instruments were administered in Sinhala to assess exposure, post-traumatic stress disorder (PTSD), depression, anxiety, somatic distress and impairment. Demographic variables and culturally-relevant coping activities were assessed.ResultsThe prevalence of clinically significant PTSD, depression and anxiety was 21%, 16% and 30% respectively. Respondents reported a mean of eight persistent and bothersome somatic complaints, which were associated with psychiatric symptoms and impairment. Thinking that one's life was in danger was the exposure item most strongly associated with symptoms and impairment. The majority of respondents found their own strength, family and friends, a Western-style hospital and their religious practice to be the most helpful coping aids.ConclusionsA large minority of adults in one area of Sri Lanka reported significant psychiatric and somatic symptoms and impairment 20–21 months after the tsunami. Accurate data about risk for and resilience to impairing symptoms > 1 year after disasters are necessary in order to develop rational surveillance and interventions.
A note on some relations among special sums of reciprocals modulo p
Authors: Skula Ladislav 
Published: January 2008

Abstract
In this note the sums s(k, N) of reciprocals
$$\sum\limits_{\tfrac{{kp}}{N} < x < \tfrac{{(k + 1)p}}{N}} {\tfrac{1}{x}(mod p)} $$
are investigated, where p is an odd prime, N, k are integers, p does not divide N, N ≥ 1 and 0 ≤ k ≤ N − 1. Some linear relations for these sums are derived using “logarithmic property” and Lerch’s Theorem on the Fermat quotient. Particularly in case N = 10 another linear relation is shown by means of Williams’ congruences for the Fibonacci numbers.
Organic Tandem and Multi‐Junction Solar Cells
Authors: Hadipour A. , de Boer B. , Blom P. W. M. 
Published: January 2008

AbstractThe emerging field of stacked layers (double‐ and even multi‐layers) in organic photovoltaic cells is reviewed. Owing to the limited absorption width of organic molecules and polymers, only a small fraction of the solar flux can be harvested by a single‐layer bulk heterojunction photovoltaic cell. Furthermore, the low charge‐carrier mobilities of most organic materials limit the thickness of the active layer. Consequently, only part of the intensity of the incident light at the absorption maximum is absorbed. A tandem or multi‐junction solar cell, consisting of multiple layers each with their specific absorption maximum and width, can overcome these limitations and can cover a larger part of the solar flux. In addition, tandem or multi‐junction solar cells offer the distinct advantage that photon energy is used more efficiently, because the voltage at which charges are collected in each sub‐cell is closer to the energy of the photons absorbed in that cell. Recent developments in both small‐molecule and polymeric photovoltaic cells are discussed, and examples of photovoltaic architectures, geometries, and materials combinations that result in tandem and multi‐junction solar cells are presented.
Retailers' response to wholesale price changes: new evidence from scanner‐based quantity‐weighted beef prices
Authors: Rojas Christian , Andino Alexandra , Purcell Wayne D. 
Published: January 2008

AbstractRetailers are often criticized for a slow response in retail prices to changes in wholesale beef prices. The unresponsiveness, especially when wholesale and farm prices are declining, is seen as a lack of competitiveness and as a reason for congressional action to regulate behavior of processors or retailers. The validity of the historical analyses of retailer price responsiveness is questionable, however. Traditional Bureau of Labor Statistics (BLS) retail beef prices biased upward and do not account for large volumes sold at discounted prices. This article uses newly available scanner‐based quantity‐weighted retail prices to suggest that retailers' response to changes in wholesale beef prices is significantly larger and possibly quicker than is shown by traditional BLS measures of retail prices. Recent efforts to prompt legislation to regulate how firms behave along the beef supply chain, which are based only on arguments that retailers are not responding to price changes at the wholesale level, may be inappropriate. [L110, L660, D400] © 2008 Wiley Periodicals, Inc.
Asymmetric price transmission in the greek agri‐food sector: some tests
Authors: Reziti Ioanna , Panagopoulos Yannis 
Published: January 2008

AbstractThis article employs a general‐to‐specific approach to analyze the price transmission mechanism between producers and consumers in the Greek agri‐food sector. More specifically, the markets examined are vegetables, fruits and the whole food. Using cointegration techniques, two alternative dynamic models are estimated: an error correction model (ECM) and a LSE‐Hendry general‐to‐specific model (GETS). The results indicate the existence of a long‐run Granger–causality relationship running from producers to consumers in the vegetables market, while the opposite applies for food and fruits. In addition, asymmetric price transmission appears to apply for food and vegetables, but not for the fruit case. Both models agree upon the asymmetric nature of food and the symmetric nature of fruits but disagree for the case of vegetables. [JEL Classification: Q110, Q130] © 2008 Wiley Periodicals, Inc.
Non‐Hodgkin's lymphoma presenting as an endobronchial tumor: Report of eight cases and literature review
Authors: Solomonov Anna , Zuckerman Tsila , Goralnik Ludmila , Ben‐Arieh Yehudit , Rowe Jacob M. , Yigla Mordechai 
Published: January 2008

AbstractNon‐Hodgkin's lymphoma (NHL) involving the endobronchial tree is uncommon, and the initial presentation of NHL as an endobronchial tumor is extremely rare. In a series of 441 patients with newly diagnosed non‐Hodgkin's lymphoma over a 7‐year period, we reviewed the clinical features of eight patients who presented with an endobronchial tumor. All patients had local pulmonary disease without extrathoracic involvement. The major presenting symptoms were dyspnea, chest pain, cough, and hoarseness. None of the patients had systemic symptoms. Radiographs revealed lobar collapse in all cases. Five patients had mediastinal masses and three had isolated endobronchial lesions. Although MALT lymphoma is the most common primary pulmonary lymphoma, it was present in only one of our patients, while seven patients had aggressive lymphoma. All patients received chemotherapy. Six of the eight patients responded favorably to treatment with complete remission. The prognosis of patients with isolated endobronchial lymphoma is not worse than other local presentations of lymphoma. Bronchoscopic examination with biopsy is essential to differentiate these lesions from primary bronchongenic carcinoma. Am. J. Hematol., 2008. © 2008 Wiley‐Liss, Inc.
The effects of a two‐hour judo training session on the neutrophil immune functions in university judoists
Authors: Umeda Takashi , Yamai Kiyonori , Takahashi Ippei , Kojima Arata , Yamamoto Yousuke , Tanabe Masaru , Totsuka Manabu , Nakaji Shigeyuki , Sugawara Norio , Matsuzaka Masashi 
Published: January 2008

AbstractThe present study examined the effects of judo training on neutrophil and related functions. We measured and studied changes in the neutrophil and its related functions in 22 male university judoists immediately before (Pre values) and immediately after (Post values) a 2 h training session: reactive oxygen species (ROS) production capability, phagocytic activities (PA) and serum opsonic activity (SOA). Neutrophil count in whole blood, myogenic enzymes (creatine kinase, lactate dehydrogenase, aspartate aminotransferase and alanine aminotransferase), immunoglobulins (IgG, IgA and IgM) and complements (C3 and C4) in serum were also measured. The Post values of the neutrophil count, myogenic enzymes and IgG increased significantly compared with the Pre values. ROS production capability and SOA also significantly increased following training, although PA showed a slight decrease (but not statistically significant). Taking the findings of our previous studies into consideration, three major neutrophil or related functions, namely ROS production capability, PA and SOA, might compensate for each other to maintain the overall integrity of the neutrophil immune function, in that ROS and SOA increased to compensate for the slight decrease in PA, or PA slightly decreased to compensate for the increase in ROA and SOA after exercise. Copyright © 2008 John Wiley & Sons, Ltd.
Growth and electrical characterization of L‐arginine added KDP and ADP single crystals
Authors: Meena M. , Mahadevan C. K. 
Published: January 2008

AbstractPotassium dihydrogen orthophosphate (KDP) and ammonium dihydrogen orthophosphate (ADP) single crystals added with L‐arginine have been grown by the solution methods. DC and AC electrical measurements were carried out at various temperatures along both a‐ and c‐ directions. Results indicate an increase of the electrical parameters with the increase of temperature which can be attributed mainly to the increase of thermally generated hydrogen bond vacancies (L. defects). Also, the present study indicates that L‐arginine addition leads to reduction of electrical parameters of KDP and ADP single crystals which can be attributed mainly to the decrease of L‐defects due to creation of additional hydrogen bonds by the impurity in random directions. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
The Use of 2,1,3‐Benzoselenadiazole as an Auxiliary Ligand for the Construction of New 2D Silver(I)/Benzene‐ or Cyclohexane‐1,3,5‐tricarboxylate Honeycomb Networks
Authors: Tan Cheng‐Kang , Wang Jing , Leng Ji‐Dong , Zheng Ling‐Ling , Tong Ming‐Liang 
Published: January 2008

AbstractThe reaction of freshly synthesized [Ag(NH3)2](OH), 2,1,3‐benzoselenadiazole (bsd) and benzene‐ or cyclohexane‐1,3,5‐tricarboxylic acid (H3btc/H3ctc) results in two new coordination polymers containing 2D Ag3(btc) and Ag3(ctc) hexagonal motifs, namely [Ag3(btc)(bsd)6]·0.5H2O (1) and [Ag3(ctc)(bsd)3]·1.5bsd·3.5H2O (2). Complex 1 is a 3D supramolecular framework extended by deformed 2D Ag3(btc) honeycomb nets via Se···N synthons formed between the dangling monodentate bsd groups, whereas 2 is a 3D metal–organic framework of nanoscale cages made up from ideal Ag3(ctc) honeycomb layers and μ2‐bridging bsd ligands.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Cross‐Coupling–Elimination Reactions Mediated or Catalyzed by Zirconium Complexes: A Valuable Tool in Organic Synthesis
Authors: Fañanás Francisco J. , Rodríguez Félix 
Published: January 2008

AbstractThe tandem zirconocene‐mediated or ‐catalyzed cross‐coupling–elimination reaction provides an efficient and versatile procedure for the construction of scaffolds that in many cases are difficult to access by traditional organic chemistry. In general, this process supposes the reaction of two unsaturated molecules. One of them is coordinated to the zirconocene and the other one contains a heteroatom at an appropriate position for the subsequent elimination process. In this Microreview we discuss the concept of this useful approach focussing on the reactivity of alkyne‐, aryne‐, alkene‐ and iminezirconocene complexes towards alkenes containing a heteroatom functionality at the allylic or vinylic position. Some examples of heteroatom‐substituted alkynes are also covered. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Neuropsychiatric symptoms in the community‐based patients with mild cognitive impairment and the influence of demographic factors
Authors: Muangpaisan W. , Intalapaporn S. , Assantachai P. 
Published: January 2008

AbstractObjectiveTo investigate the pattern of neuropsychiatric symptoms of MCI patients in the Thai population and the influence of demographic factors on the symptoms.MethodsOne hundred and seven participants aged 50 and over diagnosed with MCI (n = 77) and normal (n = 30) were recruited from a community‐based unit. The Neuropsychiatric Inventory (NPI) was used to assess behavioral disturbances in the subjects.ResultsCompared to normal subjects, MCI patients had higher incidence of anxiety (53% vs 27%, p = 0.013), dysphoria (46% vs 17%, p = 0.006), and sleep problem (45% vs 23%, p = 0.035). Although marginally significant, apathy was more common in MCI patients (12% vs 0%, p = 0.059). The mean total NPI score and NPI distress score were higher in the MCI group (6.8 vs 1.9, p < 0.0005 and 2.9 vs 0.6, p = 0.01, respectively). The MCI patients aged over 65 had higher incidence of hallucinations (18.9% vs 0%, p = 0.018). Males and patients of poor financial status had higher percentage of dysphoria compared to female and patients with better financial status (65% vs 38.5%, p = 0.041 and 75% vs 37.9%, p = 0.008, respectively). Patients with poor financial status also had higher percentage of anxiety (81.3% vs 44.5%, p = 0.01).ConclusionsMCI is associated with significant neuropsychiatric symptoms which caused caregiver distress. In this study, the pattern of neuropsychiatric symptoms in a Thai MCI population was similar to those reported in western countries. Age, sex, educational level and financial status influenced the neuropsychiatric symptoms of MCI patients. Copyright © 2008 John Wiley & Sons, Ltd.