bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between serum albumin levels and erectile dysfunction in American Adults: A cross-sectional study from NHANES 2001–2004
Authors: Wen Haibin , Lan Zhenyu , Liang Xueming , Su Huabin , Qin Yuqi 
Published: February 2025

Background
The aim of this study is to investigate the association between Serum Albumin Levels (ALB) and erectile dysfunction (ED) within the U.S. general population.

Methods
We conducted a cross-sectional analysis using data from the National Health and Nutrition Examination Survey (NHANES) 2001–2004 cycles. Serum albumin was analyzed both as a continuous variable and categorized into quartiles. Erectile dysfunction (ED) was assessed via self-reported questionnaires. The association between serum albumin and erectile dysfunction was evaluated using weighted logistic regression models across four models: (1) Crude model (unadjusted); (2) Model 1: Adjusted for age, race, poverty-to-income ratio (PIR), marital status, education level, and body mass index (BMI); (3) Model 2: Adjusted for factors in Model 1 plus physical activity, smoking status, drinking status, and Healthy Eating Index (HEI-2015); (4) Model 3: Adjusted for factors in Model 2 plus remaining potential covariates. A generalized additive model (GAM) was employed to examine non-linear associations, followed by subgroup analyses and interaction tests.

Results
A total of 2925 participants were included in the study, of which 747 were diagnosed with ED. After adjusting for all covariates, a significant negative association was found between ALB and ED (OR: 0.53, 95% CI: 0.29–0.97, P = 0.04). Higher ALB quartiles were significantly correlated with a decreased risk of ED [Q4 vs. Q1: OR: 0.56 (0.35–0.90), P =  0.02; P for trend =  0.03]. The GAM and smoothed curve fit indicated a linear relationship between ALB and the risk of ED. Stratified and interaction tests further substantiated the inverse relationship between ALB and ED prevalence.

Conclusions
This study revealed an inverse association between ALB and ED. Therefore, it is important for clinicians to recognize the assessment of ALB in patients.
Immediate and short-term effects of neurodynamic techniques on hamstring flexibility: A systematic review with meta-analysis
Authors: Núñez de Arenas-Arroyo Sergio , Martínez-Vizcaíno Vicente , Torres-Costoso Ana , Reina-Gutiérrez Sara , Bizzozero-Peroni Bruno , Cavero-Redondo Iván 
Published: February 2025

Background
Good hamstring flexibility(HF) is crucial for sports performance and health, with injuries having an economic impact on healthcare and sports teams. Therefore, our objectives were to estimate the effect of neurodynamic techniques on HF and to compare the effect of these techniques with static stretching.

Methods
We systematically searched the Cochrane, MEDLINE(via PubMed), Scopus, Web of Science and Sportdiscus databases for RCTs comparing neurodynamic interventions with control intervention or with static stretching exercises for HF in adults with limited HF. We conducted a random-effects meta-analysis with subgroup analyses according to the type of comparison group(control group or static stretching exercises) and total number of sessions. Furthermore, to reflect the variation in genuine therapy effects in different scenarios, including future patients, we calculated a 95% prediction interval(prI).

Results
Thirteen trials were included, involving 624 participants. Pooled results showed a significant improvement in HF for immediate (SMD = 1.01, 95% CI: 0.44 to 1.59) and short-term effects (SMD = 1.21, 95% CI: 0.90 to 1.52). Subgroup analyses by type of comparison group showed that these techniques are more effective than the control group in the immediate and short term and than static stretching in the short term. Analyses by total sessions showed a significant increase in HF with a treatment of 1, 3, 10 and 12 sessions.

Conclusion
Neurodynamic techniques improve HF immediately and in the short term. Subgroup analyses by type of comparison group showed that these techniques are more effective than static stretching in the short term.
Dry eye disease treatment improves subjective quality-of-life responses in patients with AMD, independent of disease stage
Authors: Mehta Nehal Nailesh , Nagel Ines D. , Agnihotri Akshay , Heinke Anna , Cheng Lingyun , Bartsch Dirk-Uwe , Freeman William R. , Gomez Maria-Laura 
Published: February 2025

Purpose
To determine the impact of severity of age-related macular degeneration (AMD) on subjective treatment response in patients treated for dry eye disease.

Methods
A total of 203 eyes diagnosed with evaporative dry eye disease (DED) due to meibomian gland dysfunction were treated using the LipiFlow or MiBoFlo systems. From this cohort, 40 eyes with stable dry AMD (early, intermediate, or late stages) were included. Each participant completed the Ocular Surface Disease Index (OSDI) and Standard Patient Evaluation of Eye Dryness Questionnaire (SPEED) before treatment and at a 6-month follow-up. Changes in questionnaire scores were analyzed using one-way analysis of variance (ANOVA) to assess differences between AMD severity groups.

Results
Improvement in SPEED and OSDI scores, including vision related OSDI scores were observed across all AMD stages, with no significant differences between groups (p<0.05).

Conclusion
Managing DED improved quality of life (QOL) in patients with AMD, regardless of retinal disease severity. This highlights the importance of treating coexisting ocular surface conditions to enhance patient outcomes, even in the presence of significant maculopathy.
Efficacy of acupuncture in treating chemotherapy-related cognitive impairment in breast cancer patients: A systematic review and meta-analysis protocol
Authors: Liu Lishi , Meng Zihan , Yan Jun 
Published: February 2025

Background
Chemotherapy-related cognitive impairment (CRCI) is a common adverse effect of chemotherapy in breast cancer patients, with a high incidence that significantly impacts treatment adherence and quality of life. Currently, there is no definitive and effective treatment for CRCI. Research indicates that acupuncture may serve as a promising intervention for CRCI. This study aims to assess the effectiveness of acupuncture in treating CRCI.

Methods
This study is guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocols (PRISMA-P). From the time of database construction to October 2024, we will search seven literature databases, three clinical study registry databases, and three sources of gray literature. The restricted languages are English and Chinese. We will use the Participants-Interventions-Comparators-Outcome-Conclusion-Study Design (PICOS) criteria to identify included studies and the RoB2 tool to assess the quality of the included studies. Data synthesis and meta-analysis will be performed using RevMan 5.3.

Discussion
The results of this study will clarify the potential benefits of acupuncture in the treatment of CRCI and address existing disagreements about its efficacy. Furthermore, the findings will assist clinicians in making informed decisions regarding the treatment of CRCI.

Trail registration
PROSPERO registration number: CRD42024568093.
An Unusual Case of Intrahepatic Stone Masquerading as Cholangiocarcinoma
Authors: Williams Alexander S. , Sikes Michael A. , Liu Scott 
Published: February 2025

ABSTRACT
A cancer of the biliary tree, cholangiocarcinoma (CCA) often presents with painless jaundice, right upper quadrant abdominal pain, and unintended weight loss. Serologic testing to include cancer antigen 19-9 (CA 19-9) is elevated in CCA but can also be elevated in inflammatory processes in the biliary system. Diagnosis is difficult and even with advanced imaging techniques false-positives may occur. We present a case of a patient with elevated CA 19-9 and biliary stricture concerning for CCA but was due to hepatic stone. It demonstrates the challenge of correctly diagnosing CCA and an instance of nonmalignant elevation of CA 19-9.
Postnatal enteral plasma supplementation following birth asphyxia increases fluid retention and kidney health in newborn pigs
Authors: Zhong Jingren , Pankratova Stanislava , Doughty Richard , Flyger Christoffer Kirkelund , Sangild Per Torp , Skovgaard Kerstin , Jensen Henrik Elvang , Nguyen Duc Ninh , Thymann Thomas 
Published: February 2025

AbstractBirth asphyxia can result in kidney dysfunction, disturbances in systemic electrolytes and fluid balance in newborns. Currently, there is no proven dietary approach to support asphyxiated newborns. This study investigates whether oral plasma supplementation improves kidney function and overall health in asphyxiated newborns. Cesarean‐delivered near‐term pigs with or without an 8 min intrauterine clamping of the umbilical cord were fed a milk replacer dissolved in water for 24 h in Experiment 1. Pigs were fed 72 h with milk replacers dissolved in either maternal plasma or water in Experiment 2. Blood, urine, and kidney tissue were collected for further analyses. Asphyxia disrupted blood electrolyte balance. And plasma feeding led to higher fluid retention for both asphyxiated and control pigs. Additionally, plasma feeding may also affect kidney development and protect kidneys from asphyxia induced impairments. Birth asphyxia in pigs led to immediate disturbance of electrolyte balance, impaired fluid retention, and kidney impairments. Plasma feeding may improve postnatal newborn hydration and may also improve the condition of kidneys following asphyxia.
Materialismus im feministischen und queeren Denken
Authors: Möser Cornelia 
Published: February 2025

Abstract
In view of the increasing social and economic inequality in recent decades, both globally and locally, more and more attempts are being made in political philosophy to understand social structures not only in terms of their symbolic and idealistic constitution, but also in the light of their underlying political-economic foundations. However, the concepts of materialism used in these works, especially in feminist thought over the last ten years, have caused much confusion due to their different meanings, especially when they are considered transnationally. This article discusses the numerous publications on materialism in feminist and queer thought and situates them in their respective contexts of origin. Their analysis is then placed in a broader context of philosophical debates on materialism in order to gain a better understanding of the dynamics at play but also in order to better grasp the contributions of feminist and queer thought to the philosophical study of materialism.
When Less Means More: Policy Accumulation, Administrative Capacities, and Policy Performance
Authors: Fernández-i-Marín Xavier , Hinterleitner Markus , Knill Christoph , Steinebach Yves 
Published: February 2025

Abstract
Democratic governments have consistently introduced new policies to address various societal, economic, and environmental issues. However, this ongoing expansion of policy measures risks overburdening the public administrations responsible for their execution. To explore this challenge, we examine how the relationship between the size of sectoral policy portfolios and available implementation capacities impacts the effectiveness of sectoral policies. Our analysis of environmental policies across OECD countries reveals a growing disparity between the number of policies requiring implementation and the resources available to carry them out, which in turn negatively affects policy performance.
Left-peripheral bottom line sequences
Authors: Pinson Mathilde 
Published: February 2025

Abstract
The N-is construction has evolved from main clause to parenthetical, and bottom line has even become a mobile marker. The spoken section of COCA shows that left-peripheral bottom line can be surrounded by other extra-clausal expressions compatible with its pragmatic functions (projection, summation/(sub)topic shift, emphasis, epistemic endorsement and objectification). The aim of this paper is to establish whether these categories exhibit ordering preferences. The study reveals that the left periphery can be divided into nine optional slots. The first four slots usually express disjunction with the previous utterance; they include turn-initiators, then discourse connectors, then markers of disalignment, and then attention-getters/(sub)topic shifters. The second part of the left periphery (Slots 5–9) is more argumentative. The fifth slot comprises subjectifiers: expressions of viewpoint meant to attenuate the peremptory tone of bottom line, which occupies the sixth slot. The seventh slot is filled by the stance-marking discourse marker though, and the eighth slot is typically composed of expressions which de-subjectify the upcoming assertion. Finally, the ninth slot is occupied by addresses, which can be used strategically to maintain the recipient in an inferior interactional position. Together, these expressions form powerful rhetorical devices meant to convince interlocutors while preserving their faces.
The impact of the COVID-19 pandemic on DKA severity in Black and White pediatric patients
Authors: Patel Shrina , Amador Elyzabeth , Fischell Jonathan M. , Bewley Erin , Jeffries Kaitlin , Newton Paula G. , Fischell Stefanie Zaner 
Published: February 2025

Abstract

Objectives
Diabetic ketoacidosis (DKA) is a complication of uncontrolled diabetes mellitus, with a known increase in severity and incidence during the COVID-19 pandemic. Our institution also observed a rise in pediatric DKA cases in our largely underserved patient population. We hypothesized that the impact would be more pronounced in Black patients due to prepandemic healthcare inequities.

Methods
To investigate this, we confirmed the increased number of severe DKA cases in our pediatric patients during the pandemic and then stratified data to compare laboratory values between Black and White patients. We analyzed patients with a DKA diagnosis admitted to our institution’s pediatric intensive care unit (PICU) prior to the pandemic (March 2016 to December 2017) and during its peak (March 2020 to December 2021).

Results and Conclusions
Our data demonstrated more cases of severe DKA overall during 2020–2021 and when compared to prepandemic years, a statistically significant increase in severity for Black, but not White patients.
The reference ranges for fetal ductus venosus flow velocities and calculated waveform indices and their predictive values for right heart diseases
Authors: Wu Jian , Ruan Yanping , Gao Xinru , Wang Hairui , Guan Yuxuan , Hao Xiaoyan , Han Jiancheng , Gu Xiaoyan , He Yihua 
Published: February 2025

Abstract

Objectives
This study endeavors to establish comprehensive normal reference ranges and Z score formulas for ductus venosus (DV) flow velocity parameters and calculated waveform indices across different gestational ages in low-risk fetuses. Furthermore, we aim to validate the predictive capabilities of these Z score calculation formulas in fetuses with diverse right heart diseases.

Methods
8,953 singleton low-risk fetuses and 70 fetuses diagnosed with different types of right heart diseases were retrospectively enrolled. The DV blood flow velocities during the cardiac cycle (ventricular systolic wave velocity [S], ventricular diastolic wave velocity [D], atrial contraction wave velocity [A], and time-averaged maximum velocity [Tamx]) and calculated waveform indices (preload index [PLI], peak velocity index [PVI], pulsatility index [PI], S/A, and S/D) were obtained. Ninety low-risk fetuses were randomly selected as the control group to verify the predictive value of the Z score model for fetuses with different types of right heart diseases.

Results
As gestational age increased (16–39 weeks), the mean values of S, D, A, and Tamx progressively increased; conversely, the mean values of PLI, PVI, PI, and S/A decreased, respectively, and the median value of S/D remained stable. The Z score-transformed A, PLI, PVI, PI, and S/A could serve as predictors of overall right heart diseases. Different DV Doppler parameter Z scores exhibited varying predictive values for different subtypes of right heart diseases.

Conclusions
Normal reference ranges and corresponding Z score calculation formulas for DV hemodynamic parameters were established, which have demonstrated significant diagnostic values in identifying right heart diseases.
Frequency-comb-referenced multiwavelength interferometry for high-precision and high-speed 3D measurement in heterogeneous semiconductor packaging
Authors: Park Jun Hyung , Kim Dae Hee , Chu Huy Hoang , Hahm Ji Won , Kang Guseon , Lee Dongil , Song Seyong , Kang Mingu , Kim Seung-Woo , Kim Young-Jin 
Published: February 2025

Abstract
As Moore’s law approaches its physical limits, the semiconductor industry has begun to focus on improving I/O density and power efficiency through 2.5D/3D packaging. Heterogeneous integration, which combines integrated circuit blocks from different linewidth processes into a single package, is central to these developments. To ensure stable connections with high yield in the back-end processes, high precision and high speed 3D surface measurement is the prerequisite. Existing methods such as white-light interferometry and confocal microscopy face challenges in balancing resolution, speed, and accuracy in 3D measurements. Here, we report a frequency-comb-referenced multiwavelength interferometry for the measurement of 3D sample profiles without 2π phase ambiguity for advanced packaging. Using four frequency-comb-referenced wavelengths with a fractional stability of 4.77 × 10−12, the measurement range was extended from ∼400 nm (λ/2) to 1 mm, with the measurement repeatability of 0.258 nm for 32 measurements. The standard step-height samples with 500-µm and 4.5-µm steps, as well as real industrial microbumps in heterogeneous integration packaging, were all successfully measured. Therein, we devised a sequential phase detection method, which enables 5,000 times faster solution determination than the traditional recursive excess fraction method, while maintaining its reliability under noisy conditions. As 2.5D/3D packaging architectures become increasingly complex, our approach will readily meet the critical industrial demands for high-precision and high-speed measurement of multiscale features in advanced semiconductor packaging.
The crystal structure of the double salt potassium 1-methylpiperazine-1,4-di-ium trinitrate, C5H14KN5O9
Authors: Shang Yi-Ping , Wu Jun-Ying , Yao Yu-Le , Liu Rui-Zheng , Liu Dan-Yang , Chen Lang 
Published: February 2025

Abstract
C5H14KN5O9, orthorhombic, Pbca (no. 61), a = 10.4760(3) Å, b = 14.0476(4) Å, c = 17.3708(5) Å, V = 2,556.33(13) Å3, Z = 8, T = 100 K, R

gt
(F) = 0.0226, wR

ref
(F
2) = 0.0607.
Extreme value techniques for stress scenario selection under elliptical symmetry and beyond
Authors: Zhou Menglin , Nolde Natalia 
Published: February 2025

Abstract
The paper considers the problem of stress scenario selection, known as reverse stress testing, in the context of portfolios of financial assets.
Stress scenarios are loosely defined as the most probable values of changes in risk factors for a given portfolio that lead to extreme portfolio losses.
We extend the estimator of stress scenarios proposed in [P. Glasserman, C. Kang and W. Kang, Stress scenario selection by empirical likelihood, Quant. Finance
15 (2015), 1, 25–41] under elliptical symmetry to address the issue of data sparsity in the tail regions by incorporating extreme value techniques.
The resulting estimator is shown to be consistent, asymptotically normally distributed and computationally efficient.
The paper also proposes an alternative estimator that can be used when the joint distribution of risk factor changes is not elliptical but comes from the family of skew-elliptical distributions.
We investigate the finite-sample performance of the two estimators in simulation studies and apply them on two financial portfolios.
Exploring the interactions in the mixtures of cationic Gemini and biologically significant anionic surfactant sodium cholate in presence of drug proponolol hydrochloride
Authors: Sood Ashwani Kumar , Aggarwal Meenu 
Published: February 2025

Abstract
The objective of the present study is to evaluate the binding properties of active pharmaceutical ingredients with mixture of surfactants with the aim of reducing the amount of the surfactants as well as the excipient for the pharmaceutical formulations and drug delivery applications. Therefore, a study of the interactions between the ionic surfactant sodium cholate (SC) and a cationic Gemini surfactant (12-2-12) in the presence of the drug propanolol hydrochloride (PH) in aqueous solution was carried out using conductance measurements. The effect of temperature and composition of the mixture was evaluated using critical micelle concentration (CMC) and other related parameters. For the mixture of SC + 12-2-12 in aqueous PH solution, the CMC of the mixed systems (CMCexp) decreases with increasing temperature. However, at a fixed temperature, CMCexp tends to decrease with increasing mole fraction (α
1), reaching a minimum at α
1 ≈ 0.7 and increasing thereafter. The ideal value of the CMC (CMCid) is always higher than the experimental CMCexp, revealing synergistic interactions among the amphiphilic molecules studied. The free energy of micellization (ΔG
o
m) is negative, while the enthalpy and entropy of micellization (ΔH
o
m and ΔS
o
m) suggest the existence of hydrophobic interactions as the main driving force for micellization.
Higher-order corrections on the denaturation of homogeneous DNA thermodynamics
Authors: Pourhassan Behnam , Sakallı İzzet , Tüzmen Şükrü , Shi Xiaoping , Faizal Mir 
Published: February 2025

Abstract
DNA denaturation, the process of separating double-stranded DNA into single strands, plays a critical role in fundamental biological processes such as transcription, replication, and repair. Despite extensive studies on its thermodynamic properties, the effects of thermal fluctuations on DNA denaturation have not yet been explored. This paper addresses this gap by developing a statistical mechanical model to analyze homogeneous DNA denaturation thermodynamics with thermal fluctuations. Using the partition function framework, this study introduces two major corrections to the entropy of the system induced by thermal fluctuations: (1) a logarithmic correction of the leading order and (2) a higher-order correction term proportional to the inverse of the entropy. Analytical calculations and numerical analysis reveal that these corrections significantly influence the thermodynamic properties, including specific heat and free energy, leading to a more nuanced understanding of the DNA melting process. The corrected entropy modifies the specific heat profile, resulting in a sharp peak that reflects a first-order phase transition during DNA denaturation. The inclusion of higher-order corrections introduces asymmetry in the specific heat curve, highlighting the cooperative behavior of DNA melting. Furthermore, the free-energy analysis suggests the presence of intermediate states during strand separation, which are critical for understanding the initiation and propagation of the denaturation process. The results align well with experimental DNA melting profiles, particularly in the transition region, and provide insights into the microscopic mechanisms underlying DNA melting. This study not only advances the theoretical framework for DNA denaturation by explicitly incorporating thermal fluctuations but also offers a platform for future experimental validation and applications in biological systems. These findings have broader implications for understanding DNA stability under physiological conditions, cellular processes such as transcription initiation, and the role of ionic environments in modulating DNA thermodynamics.