bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acute arthritis caused by aeromonas hydrophila. Clinical and therapeutic aspects
Authors: Chmel Herman , Armstrong Donald 
Published: February 2007

AbstractTwo cases of Aeromonas hydrophila arthritis are reported and a third case present in the literature is reviewed. All three cases occurred in patients with myelogenous leukemia; the knee joint was involved in 2 patients and the metacarpal—phalangeal joint in the third. In the 2 patients presented here, synovial fluid antibiotic levels were measured and were adequate; but A hydrophila was repeatedly cultured from the knee joints, a fact suggesting that other factors, such as normal functioning leukocytes and specific opsonizing antibody against the organism, are also necessary to kill A hydrophila.
Fibrinogen catabolism in systemic lupus erythematosus
Authors: Sergent John S. , Sherman Raymond L. , Al‐Mondhiry Hamid 
Published: February 2007

AbstractBecause there is mounting evidence that localized intravascular coagulation maycontribute to tissue injury following a variety of immunologic events, including immune complex diseases, fibrinogen catabolism was studied in patients with systemic lupus erythematosus to determine factors correlating with accelerated coagulation. 125I‐fibrinogen half‐life in controls was 80.1 ± 11 hours and the mean SLE half‐life was 60.5 ± 12. SLE patients in complete clinical remission had normal half‐lives, but patients with symptomatic clinical disease, including renal disease, had significantly reduced fibrinogen survival. Accelerated fibrinogen consumption also correlated with positive tests for anti‐DNA antibodies, but not with hypocomplementemia. These observations support the hypothesis that the coagulation system is activated in patients with immune complex diseases. Further studies are required to define the role, if any, that coagulation may play in causing tissue injury.
Metabolic changes in rabbit articular cartilage due to inflammation
Authors: Deshmukh Kalindi , Hemrick Susan 
Published: February 2007

AbstractThe effects of inflammation on the articular cartilage of rabbit knee joints were studied. The inflammation was induced by intraarticular injections of croton oil or rabbit peritoneal leukocyte lysates. An increase in the activities of various lysosomal enzymes was observed in the synovial fluid as well as in the cartilage of the inflamed joints. Loss of proteoglycans, increased rate of degradation of collagen and proteoglycans, and increased rate of their synthesis were evident in the treated cartilage. The rate of uptake of 3H‐thymidine was also increased. A significant change was observed in the type of collagen synthesized by these explants in vitro. In addition to synthesizing their characteristic Type II collagen, the cartilage explants from the treated joints synthesized Type I collagen.
Differentiation and characterization of autoantibodies and their antigens in sjögren's syndrome
Authors: Alspaugh Margaret A. , Talal Norman , Tan Eng M. 
Published: February 2007

AbstractAutoantibodies in Sjögren's syndrome (SS) were identified by their precipitin reactions with tissue antigens in immunodiffusion. The source of antigens was a sonicated extract of human lymphoid cells (WiI2) grown in tissue culture. Three distinct precipitin systems were identified and referred to as precipitins SS‐A and SS‐B, and rheumatoid arthritis precipitin. These studies show that precipitins SS‐A and SS‐B are present in high frequency in sera of patients with SS without associated rheumatoid arthritis (RA) and are absent or present in low frequency in many other connective tissue diseases. On the other hand patients with SS who also had clinical features compatible with RA (SS‐RA) did not have precipitins SS‐A and SS‐B but had rheumatoid arthritis precipitin (RAP). The latter precipitin was also present in RA patients in a similar order of frequency as in SS‐RA. All three precipitin systems were shown to be reactions between immunoglobulins and cellular antigens. The origin of SS‐A and SS‐B antigens was demonstrated by immunofluorescence to be primarily from the nucleus but the origin of RAP in the cell has not been established.
Carpal arthritis with ankylosis in late onset still's disease
Authors: Medsger Thomas A. , Christy Wallace C. 
Published: February 2007

AbstractThirteen patients are described in whom Still's disease began after age 15. All had objective evidence of arthritis, and 10 developed chronic synovitis of larger joints, especially the wrists. A characteristic evolution of roentgenographic changes was observed in 7 patients. Carpometacarpal and intercarpal joint spaces became selectively narrowed without erosions, and bony ankylosis eventually occurred. These roentgenographic changes may be a valuable clue to the diagnosis of Still's disease, regardless of the age at onset.
Predominance of t cells in the lymphocytic infiltrates of synovial tissues in rheumatoid arthritis
Authors: Bankhurst Arthur D. , Husby Gunnar , Williams Ralph C. 
Published: February 2007

AbstractSynovial tissues from 5 patients with rheumatoid arthritis (RA) were examined with immunofluorescence microscopy for the presence of lymphocytes with either bone marrow‐derived (B) or thymus‐derived (T) surface markers. Five synovial tissues with severe to mild lymphocytic infiltrations by bright field microscopy were examined in parallel with immunofluorescence. B cells were identified with a pepsin‐digested fluoresceinated anti‐F (ab')2 antiserum and T cells were detected with a specific rabbit anti‐T lymphocyte antiserum. By these techniques 75–90% of the lymphocytes in these frozen sections were identified as T cells. Cell suspensions were also prepared by collagenase digestion of two of the five synovial tissues. The lymphocytes in these cell suspensions were predominantly T lymphocytes (78–85%) as shown by their ability to form spontaneous rosettes with sheep erythrocytes (E rosettes).
Antibodies to native and denatured collagens in sera of patients with rheumatoid arthritis
Authors: Andriopoulos Nicolaos A. , Mestecky Jiri , Miller Edward J. , Bradley Edwin L. 
Published: February 2007

AbstractA passive hemagglutination assay was used to detect antibodies to native human collagens and to collagen chains in the sera of 110 rheumatoid patients and those of 75 normal controls. The incidence and titer of anticollagen antibodies in rheumatoid arthritis are high, but in controls they are low or in most instances absent. No correlation was found between the stage of RA, or titers of rheumatoid factor, or ANA and the incidence and/or titers of antibody to any given type of collagen.
Lymphocytotoxic antibody activity in cryoprecipitates from serum of patients with SLE
Authors: Zvaifler Nathan J. , Bluestein Harry G. 
Published: February 2007

AbstractComplement‐dependent cytotoxic activity against normal human peripheral blood lymphocytes was detected in 11 of 17 cryoprecipitates from the serum of patients with systemic lupus erythematosus (SLE). The lymphocytotoxicity was eliminated by treatment with 2‐mercaptoethanol and iodoacetamide, and it was inhibited by antibody to human IgM but not anti‐IgG. The titers of lymphocytotoxic activity in the cryoprecipitates were roughly proportional to the corresponding serum titers, but when they were normalized for IgM concentration it was apparent that selective concentration of lymphocytotoxic antibody occurred in the cryoglobulins. The relationship between cryoprecipitable lymphocytotoxicity and a number of laboratory and clinical parameters of SLE was studied. The amount of protein in the cryoprecipitates, which was greatest in patients with significant renal disease, correlated with a reduction of serum complement and the amount of antibody to DNA. However the lymphocytotoxic activity of the cryoglobulins did not correlate with the severity of SLE. The titer of lymphocytotoxic antibody was independent of a) the presence or absence of active lupus nephritis, b) the total protein or immunoglobulin content of the cryoprecipitates, c) serum complement levels, and d) the amount of circulating antibody to DNA. These findings cast doubt upon the pathogenetic significance of cryoprecipitable lymphocytotoxic antibody.
Study of thymic factors. II. Failure of thymosin to alter the natural history of nzb and nzb/nzw mice
Authors: Gershwin M. Eric , Steinberg Alfred D. , Ahmed Aftab , Derkay Craig 
Published: February 2007

AbstractThe effects of daily injections of thymosin, bovine fraction V, on the natural history of NZB and NZB/NZW F1 mice were investigated. With the use of several dose schedules, no significant differences were discovered in treated versus control groups when survival, autoantibodies, and mitogen responsiveness were compared. These results provide further evidence that thymosin may have little or no role in the treatment of the autoimmune disease of New Zealand mice. More encouraging research in thymic extracts and their measurement is necessary before clinical trials in SLE are considered.
Association of Sjögren's syndrome with HLA‐B8
Authors: Fye Kenneth H. , Terasaki Paul I. , Moutsopoulos Haralampos , Daniels Troy E. , Michalski Joseph P. , Talal Norman 
Published: February 2007

AbstractHLA antigens were examined by microdroplet lymphocyte cytotoxicity in 31 patients with Sjögren's syndrome. Fifty percent of 22 Caucasian patients (7 of 17 females and 4 of 5 males) had HLA‐B8, as compared to 21% of 1205 controls (P = 0.002). The presence of HLA‐B8 was not correlated with parotid salivary flow, kerato‐conjunctivitis sicca, or focus score. Because of its association with a number of autoimmune diseases, including Sjögren's syndrome, it is suggested that HLA‐B8 is genetically linked to an immune response gene(s) that predisposes the individual to autoimmune phenomena. The expression of autoimmunity may be determined by infectious or environmental factors.
Rheumatoid factor in acute bacterial endocarditis
Authors: Sheagren John N. , Tuazon Carmelita U. , Griffin Calvin , Padmore Neville 
Published: February 2007

AbstractSera from 55 parenteral drug abusers with endocarditis due to Staphylococcus aureus were assayed for the presence and titer of rheumatoid factor. Thirteen (24%) of the 55 patients with endocarditis had sera positive for rheumatoid factor at one point or another in their courses; only 2 (7%) of 30 noninfected drug users were found to be positive. It appeared that more severe cases, as evidenced by duration of fever after initiation of antibiotic therapy, were more likely to develop rheumatoid factor.
Fibrous myopathy. A rheumatic complication of drug abuse
Authors: Johnson Kent R. , Hsueh Willa A. , Glusman Sheldon M. , Arnett Frank C. 
Published: February 2007

AbstractA progressive fibrous myopathy may result from chronic intramuscular drug abuse. This complication may mimic other rheumatic disorders and early recognition may prevent disability. The patient described here presented with fixed flexion and extension contracture of hips and knees, respectively, after abusing meperidine and other agents for 3 years. Soft tissues of thighs and buttocks were “wood hard,” EMG showed absence of action potentials in affected muscles, and biopsy revealed extensive replacement of muscle with dense, acellular fibrous tissue. Possible mechanisms are discussed.
Effect of fenoprofen calcium on acute gouty arthritis
Authors: Wanasukapunt Sunt , Lertratanakul Yongsuk , Rubinstein Herbert M. 
Published: February 2007

AbstractTwenty‐seven patients with thirty‐six joints affected with acute gouty arthritis were treated with fenoprofen calcium for a duration not exceeding 8 days and with a variable dose not exceeding 3.2 g daily. The results indicate that fenoprofen calcium was an effective drug in these patients. Side effects were modest.
The lupus anticoagulant
Authors: Boxer Michael , Ellman Leonard , Carvalho Angelina 
Published: February 2007

AbstractThe clinical and laboratory experience with the lupus anticoagulant was reviewed in 37 patients. The anticoagulant is thought to act by blocking the activation of prothrombin by the prothrombin activator complex of factors Xa, V, and phospholipid. Although the anticoagulant has been principally associated with diseases of immune origin, 14 of the present patients had disorders not thought to be immune in nature. Eighteen patients underwent twenty‐one operative procedures with only a single episode of excessive bleeding. In the authors' experience, the lupus anticoagulant is a rare cause of bleeding.
Clinical significance of immune deposits in the skin in SLE
Authors: Wertheimer David , Barland Peter 
Published: February 2007

AbstractThe lupus band test (LBT) was evaluated in 53 SLE patients. There was no significant correlation between the presence of a positive LBT and active clinical nephritis, renal histology, hypocomplementemia, or elevated anti‐nDNA antibodies. In 14 patients the classes of immunoglobulins in the skin and the glomeruli were directly compared and differences were present in 11 patients. Repeat LBTs frequently became positive in patients after successful suppression of disease activity.
Frequency of neoplasia in systemic lupus erythematosus and rheumatoid arthritis
Authors: Lewis Robert B. , Castor C. William , Knisley Robert E. , Bole Giles G. 
Published: February 2007

AbstractA patient population admitted to the hospital for either SLE or RA was surveyed for the subsequent development of neoplasms. The frequency of neoplasm in SLE patients appeared to be exaggerated, whereas the frequency of subsequent neoplasm in rheumatoid patients was unexpectedly low. A paucity of nephritis in the SLE group was noted. Further reports are encouraged so that the magnitude of the risk of malignancy developing with immunosuppressive therapy can be more precisely ascertained.
Lymphocyte response to virus antigens in systemic lupus erythematosus
Authors: Wolf Robert E. , Ziff Morris 
Published: February 2007

AbstractThe cell‐mediated immune response of lymphocytes to rubella, measles, parainfluenza types 1, 2, and 3, varicella‐zoster, and herpes virus type 1 virus antigens was evaluated in 15 SLE patients and 15 matched controls by incorporating 3H‐thymidine in whole blood cultures as a measure of blastic transformation. SLE patients were less responsive than normal individuals to six of eight virus antigens tested. Culture of washed SLE cells in AB plasma did not reverse the hyporesponsiveness. The results indicated that a functional impairment of the circulating lymphocytes appeared to be responsible for the in vitro hyporesponsiveness of SLE patients to virus antigens.
Organic brain syndrome in rheumatoid arthritis following corticosteroid withdrawal
Authors: Gupta Ved P. , Ehrlich George E. 
Published: February 2007

AbstractSix patients with seropositive nodule‐forming rheumatoid arthritis developed severe central nervous system manifestations consistent with a diagnosis of organic brain syndrome. Organic brain syndrome occurred while 5 of these patients were undergoing corticosteroid withdrawal after prolonged administration. Neuropsychiatric symptoms rapidly cleared, responding to reinstitution of oral or parenteral corticosteroids in large doses in 4 patients, to increase in dosage in 1 patient, and to no drug therapy in the remaining 1. Marked reduction in rheumatoid factor in sera and demonstration of IgM deposits in the choroid plexus in 1 of the patients raised the possibility of immune complex‐mediated central nervous system vasculitis.
Systemic lupus erythematosus associated with klinefelter's syndrome
Authors: Stern R. , Fishman J. , Brusman H. , Kunkel H. G. 
Published: February 2007

AbstractStudies in estrogen metabolism were carried out in 2 males with systemic lupus erythematosus (SLE) who also had Klinefelter's syndrome. Although these studies revealed elevated levels of urinary estrogens in 1 patient, abnormalities of estradiol metabolism suggesting persistent estrogen stimulation were detected in both. This report notes an association between SLE and Klinefelter's syndrome and suggests that chronic estrogenic stimulation may be significant in the development of SLE in these 2 patients.
Avidity of antibodies in sle
Authors: Leon Shalom A. , Green Anthony , Ehrlich George E. , Poland Marcia , Shapiro Bernard 
Published: February 2007

AbstractThe avidity of antibodies to DNA in the sera of 8 patients with SLE was determined by saturation analysis and Scatchard plots. Five of the patients had severe lupus nephritis; the other 3 had relatively mild or no kidney disease. The Scatchard plots revealed components with high relative avidity in the patients with severe nephritis (K values 4.4–10.4 x 105 M−1 for nDNA), compared with the patients who had mild or no kidney disease (K values 0.3–1.8 x 105 M−1 for nDNA). Avidity measurements may be helpful in the evaluation and treatment of patients with SLE.
Evidence of rheumatoid arthritis in ancient india
Authors: Sturrock R. D. , Sharma J. N. , Buchanan W. W. 
Published: February 2007

AbstractThe scarcity of references in ancient medical literature to any disease resembling rheumatoid arthritis (RA) has led many WEstern rheumatologists to believe that rheumatoid arthritis is a disease of relatively recent origin. In a recent paper on this problem, Short traces the first adequate description of what was probably rheumatoid arthritis to Thomas Sydenham (1624–1689) and emphasizes that European and Greek medical literature before Sydenham's time may have confused gout and other forms of polyarthritis as manifestations of the same disease (1). Studies in human paleopathology have as yet produced no convincing evidence for the existence of RA in ancient human remains, but Short suggested that a study of the ancient medical literature of the Eastern civilizations may provide some new information on the true antiquity of rheumatoid arthritis (1).
Effect of altered lymphocyte function on immunologic disorders in nzb/nzw mice
Authors: Mehta Jagdish , Knotts Linda L. , Hahn Bevra H. 
Published: February 2007

AbstractNZB/NZW F1 female mice were treated with the immunosuppressive enzyme L‐asparaginase (Asnase) for up to 32 weeks. Asnase diminished circulating anti‐DNA and antinuclear antibodies, diminished deposition of γ‐globulins in kidneys, significantly delayed the onset of proteinuria, and reduced deaths from nephritis. These effects were associated with reduction of cellular IgM antibody synthesis to both T‐dependent and T‐independent antigens, but the graft‐versus‐host reaction was not affected. After several weeks of therapy, antibodies against Asnase appeared in the circulation, the effect on antibody synthesis was lost, ANA and anti‐DNA appeared, followed by proteinuria and deaths from nephritis. Therefore Asnase proved to be an effective therapy in NZB/NZW mice, but its usefulness was limited by the appearance of inactivating antibodies.
Glucocorticosteroid inhibition of nonphagocytic discharge of lysosomal enzymes from human neutrophils
Authors: Ignarro Louis J. 
Published: February 2007

AbstractGlucocorticosteroids and mineralocorticosteroids were tested for their capacity to inhibit the nonphagocytic discharge of two lysosomal enzymes—a cartilage matrix‐degrading neutral protease and β‐glucuronidase—from highly purified human neutrophils. Lysosomal enzyme discharge from neutrophils adherent to nonphagocytizable, immobilized, heat‐aggregated IgG was inhibited by the four glucocorticosteroids—methylprednisolone sodium succinate, triamcinolone acetonide hemisuccinate, para‐methasone acetate, and hydrocortisone sodium succinate. These glucocorticoids also inhibited zymosan‐induced release of β‐glucuronidase from neutrophils that had been pretreated with cytochalasin B in order to completely prevent the onset of phagocytosis. Inhibition by the glucocorticoids of lysosomal enzyme discharge provoked by a soluble divalent cation ionophore was also observed. Neither desoxycorticosterone acetate nor aldosterone hemisuccinate, two mineralocorticosteroids, inhibited lysosomal enzyme release. Similarly, the salt moieties of some of the steroids tested, such as sodium succinate and sodium acetate, failed to elicit an effect on enzyme release. Therefore interference with lysosomal enzyme discharge was restricted to the glucocorticosteroid ring structure. Because interference either with the adherence of neutrophils to immune reactants or with the activities of the discharged lysosomal enzymes by the glucocorticoids could be interpreted as inhibition of lysosomal enzyme release, steroidal effects on these parameters were examined. None of the glucocorticoids tested elicited any significant effects on neutrophil adherence or lysosomal enzyme activity. Thus it appears that glucocorticosteroids are capable of inhibiting directly the nonphagocytic discharge of lysosomal enzymes from human neutrophils.
Differences in the collagen types synthesized by lapine articular chondrocytes in spinner and monolayer culture
Authors: Norby David P. , Malemud Charles J. , Sokoloff Leon 
Published: February 2007

AbstractIn five different secondary monolayer cultures of rabbit articular chondrocytes, 72−89% of the collagen synthesized was Type I, as determined by α chain separation and CNBr‐cleavage peptide analysis. When sister cells were transferred to spinner bottles after primary monolayer culture growth, 88% of the collagen formed in four separate experiments was Type II. A reversion to Type I collagen synthesis occurred when the spinner‐cultured cells were returned to monolayer flasks. The change in the species of collagen depended on the suspension condition and not on the low Ca2+ content (0.33 mM) of the spinner medium. These findings parallel the switch to phenotypic glycosaminoglycan synthesis that also occurs when monolayer‐cultured cells are transferred to spinner bottles. Whether this phenomenon arises through a genetic control mechanism rather than environmental selection for particular cohorts of cells has not yet been determined.
Synovial chondromatosis affecting the temporomandibular joint
Authors: Rosen Phillip S. , Pritzker Kenneth P. H. , Greenbaum Joseph , Holgate Richard C. , Noyek Arnold M. 
Published: February 2007

AbstractA case of synovial chondromatosis affecting the temporomandibular joint is reported and the literature is reviewed. Chondromatosis occurs most frequently in this joint in middle‐aged women, and it presents with pain and tenderness over the joint. Radiologically, the condition is detected by widening of the joint space with the variable presence of radiodense loose bodies. Pathologically, the loose bodies in the case presented were demonstrated to arise from cartilaginous metaplasia of the synovial lining. The stimulus for synovial chondrometaplasia at this site is unknown.
Immunohistochemical localization of prostaglandin e in rheumatoid synovial tissues
Authors: Husby Gunnar , Bankhurst Arthur D. , Williams Ralph C. 
Published: February 2007

AbstractSynovial tissues removed at synovectomy from patients with active rheumatoid arthritis (RA) or osteoarthritis (OA) were examined for prostaglandin E (PGE) by immunohistochemical techniques using rabbit antisera specific for PGE. Marked increments of PGE were noted in RA synovia in comparison to OA, with staining concentrated in synovial lining cells, interstitial inflammatory cells, and endothelial cells of blood vessels. A correlation was noted between the degree of synovial lymphocytic infiltrate and the intensity of PGE staining. These studies provide initial cellular localization of PGE in such tissues.