bluuebunny/crossref_metadata_2025_split huggingface dataset:
Expression of αCP‐4 inhibits cell cycle progression and suppresses tumorigenicity of lung cancer cells
Authors: Castaño Zafira , Vergara‐Irigaray Nuria , Pajares Maria J. , Montuenga Luis M. , Pio Ruben 
Published: October 2007

AbstractThe protein αCP‐4 (also known as hnRNP E4) is an RNA binding protein encoded by a gene at 3p21, one of the most common altered regions in lung cancer. It has been proposed that αCP‐4 may function as a lung tumor suppressor. Lack of αCP‐4 expression is frequent in highly proliferative lung tumors and correlates with αCP‐4 allele losses. The aim of this study was to evaluate the effect of αCP‐4 on the tumorigenic capacity of lung cancer cells. αCP‐4 expression was induced by transient transfection or stable infection with recombinant retroviruses. Induction of αCP‐4 expression caused cell cycle arrest in G2/M in 3 out of the 7 lung cancer cell lines studied, while no effect on apoptosis was observed. Anchorage‐independent growth and invasion capacity of H1299 cells were significantly reduced by αCP‐4 induction. Tumorigenicity of H1299 cells in nude mice was greatly inhibited by the expression of αCP‐4. Moreover, induction of αCP‐4 expression in already established tumors resulted in a sudden growth arrest. Immunocytochemistry analysis of the xenograft tumors revealed an in vivo effect of αCP‐4 on cell proliferation and no effect on apoptosis. Finally, αCP‐4 showed a subcellular localization different from αCP‐4a, a splice variant that does not affect cell proliferation. In conclusion, expression of αCP‐4 can inhibit proliferation and tumorigenesis of lung cancer cells, both in vivo and in vitro, by delaying the progression of the cell cycle. © 2007 Wiley‐Liss, Inc.
Recent advances in strategies for immunotherapy of human papillomavirus‐induced lesions
Authors: Kanodia Shreya , Da Silva Diane M. , Kast W. Martin 
Published: October 2007

AbstractHuman papillomavirus (HPV)‐induced lesions are distinct in that they have targetable foreign antigens, the expression of which is necessary to maintain the cancerous phenotype. Hence, they pose as a very attractive target for “proof of concept” studies in the development of therapeutic vaccines. This review will focus on the most recent clinical trials for the immunotherapy of mucosal and cutaneous HPV‐induced lesions as well as emerging therapeutic strategies that have been tested in preclinical models for HPV‐induced lesions. Progress in peptide‐based vaccines, DNA‐based vaccines, viral/bacterial vector‐based vaccines, immune response modifiers, photodynamic therapy and T cell receptor based therapy for HPV will be discussed. © 2007 Wiley‐Liss, Inc.
Applying the Infant‐Toddler Social & Emotional Assessment (ITSEA) and Brief‐ITSEA in early intervention
Authors: Briggs‐Gowan Margaret J. , Carter Alice S. 
Published: October 2007

AbstractTo examine the internal consistency and validity of the Infant‐Toddler Social and Emotional Assessment (ITSEA) and Brief‐ITSEA (BITSEA) parent‐report questionnaires in an early intervention sample. A sociodemographically diverse sample of 192 parents of 11‐ to 36‐month‐old children referred to early intervention programs completed surveys containing the ITSEA, BITSEA, and Child Behavior Checklist (CBCL). Parents were interviewed with the Vineland Adaptive Behavior Scales. Evaluators blind to children's status on the ITSEA and BITSEA rated child behavior during developmental assessments. Finally, a subsample of 71 children was administered the Mullen Scales of Early Learning. Findings support the internal consistency of the ITSEA and BITSEA, with the majority of Cronbach's alphas above .70. Supporting validity, ITSEA and BITSEA problem scores correlated significantly with CBCL Internalizing and Externalizing scores (rs=.28 to .78), as well as with observational ratings of problem behaviors on constructs paralleling the ITSEA domains (rs=.21 to .45). In contrast, ITSEA Competence and BITSEA Competence demonstrated moderate negative associations with CBCL scores (rs=−.39 to −.43). Finally, ITSEA Competence and BITSEA Competence correlated significantly with developmental level on the Mullen, Vineland Socialization, and observational ratings of competence (rs=.25 to .43). Emphasizing the importance of addressing social‐emotional issues in early intervention settings, 58.6% of children had high social‐emotional/behavioral problems and/or low competence on the ITSEA; 39.8% had high ITSEA Problems and 38.5% had low ITSEA Competence. Results indicate the need to assess social‐emotional adjustment in early intervention settings and support the use of the ITSEA and BITSEA for this purpose.
With a little help from my friends?: Self‐regulation in groups of young children
Authors: Mccabe Lisa A. , Brooks‐Gunn Jeanne 
Published: October 2007

AbstractThis study examined self‐regulation in preschool children (mean age=51 months; 47% boys) using three situational assessments tapping delay of gratification and motor control. Assessments represented a novel adaptation for use with both individual (N=116) and groups (N=44) of four familiar peers in ecologically valid settings. Results suggest that preschoolers demonstrate an increasing ability to self‐regulate with age, as well as some evidence for girls performing better than boys on the Gift Wrap situational assessment. Children were less able to demonstrate self‐regulation in the peer group context as compared to individual assessments. Differences between age groups and gender were not significant when children were assessed with their peers. The influence of peers on self‐regulation behavior is a complex relationship with no clear patterns identified in this research. Implications for future research and assessment efforts are discussed.
Measures of effortful regulation for young children
Authors: Spinrad Tracy L. , Eisenberg Nancy , Gaertner Bridget M. 
Published: October 2007

AbstractEmotion‐related regulation is a topic of increasing interest among researchers, yet there is little agreement on ways to measure emotion regulation in young children. In this paper, we first consider important conceptual distinctions in regard to the different types of emotion‐related regulation and control. Next, we describe a number of ways researchers have assessed children's regulation. We also present data from the Toddler Emotional Development project, in which laboratory‐based measures of effortful regulation were used. In this section, we highlight the measures that show promise (and those that did not work well). Future directions for research on the measurement of effortful regulation are presented
Conundrums in the use of observational measures of socioemotional behavior
Authors: Martin Mcdermott Jennifer N. , Fox Nathan A. 
Published: October 2007

AbstractThe potential for translation of observational measures of social and emotional behavior used in small‐scale studies for use in large‐, possibly national‐scale, studies of child development is currently an unresolved challenge. To begin to address this issue, the advantages and disadvantages to using observational measures of social and emotional behavior are discussed. In addition, alternatives to observational measures that may be helpful in assessing social and emotional behavior are considered with special emphasis on the benefits of cognitive measures.
Commentary: Difficulties assessing social and emotional behavior in large‐scale national studies
Authors: Fitzgerald Hiram E. 
Published: October 2007

AbstractInnovations in the assessment of emotional development provide new opportunities to track behavioral undercontrol from early childhood to adolescence and adulthood. Less attention is given to the assessment and measurement of negative affect. Questionnaires used to measure emotions and emotion‐regulated behavior have strong psychometric properties. Large‐scale population studies provide challenges for large assessment batteries and place great pressure for the use of short forms, but it is not always clear that short forms share the psychometrics strengths of their longer versions. Use of narratives provides opportunities to gain deeper insights into the child's experiential world. Overall, the diverse set of measurement tools that has been developed to assess emotion‐regulated behavior during the earliest years contributes to our ability to design effective prevention programs or intervention strategies to shift developmental pathways.
Hydrologic and economic evaluation of water‐saving options in irrigation systems
Authors: Khan S. , Abbas A. , Gabriel H. F. , Rana T. , Robinson D. 
Published: October 2007

AbstractThis paper investigates a range of water savings options at irrigation system level and ranks these options according to the potential savings of each option and the economic return in terms of water saved (ML – megalitres) for each dollar invested. Most of the work was conducted on large‐area farms of the Murrumbidgee Irrigation Area (MIA) and Coleambally Irrigation Area (CIA) in the Murrumbidgee River catchment, New South Wales, Australia. Field‐based on‐farm water savings for scenarios analysed ranged from 0.1 ML ha−1 up to 3.9 ML ha−1 (10–390 mm). As capital can be a limiting resource to farmers, options that have the lowest cost per ML saved may be more appealing than options that have a higher cost but may also have higher net benefits over time. The water savings that derived the highest net benefit per megalitre saved were conversion to drip and subsurface drip for the case study farms and laser levelling which had net benefits ranging from A$ 1 64 to A$ 344 ML−1 saved per year. All of the other options had net benefits ranging from A$ 4 to A$ 37 ML−1 saved per year. All of the options that had a low annualised cost also had a relatively low net benefit (less than A$ 24 ML−1 saved per year). Marginal costs of off‐farm water savings increase with the volume of water saved. In the MIA up to 20 GL (1 gigalitre = 1 MCM million cubic metres) of potential water savings are possible at a marginal capital cost of around A$ 1500–2000 ML−1. Marginal capital costs then rise rapidly, reaching A$ 4000 ML−1 at around 38 GL reflecting the lower volumes saved at higher costs. Copyright © 2007 John Wiley & Sons, Ltd. A$ = Australian dollar. 1 A$ = 0.81 US$ (2007).
Beneficial effect of hydrophilized porous polymer scaffolds in tissue‐engineered cartilage formation
Authors: Ju Young Min , Park Kwideok , Son Jun Sik , Kim Jae‐Jin , Rhie Jong‐Won , Han Dong Keun 
Published: October 2007

AbstractThree dimensional (3D) porous poly(L‐lactic acid) (PLLA) scaffolds were fabricated using a modified gas foaming method whose effervescent porogens were a mixture of sodium bicarbonate and citric acid. To improve chondrocyte adhesion, the scaffolds were then hydrophilized through oxygen plasma treatment and in situ graft polymerization of acrylic acid (AA). When the physical properties of AA‐grafted scaffolds were examined, the porosity and pore size were 87 ∼ 93% and 100 ∼ 300 μm, respectively. The pore sizes were highly dependent on the varying ratios (w/w) between porogen and polymer solution. Influenced by their pore sizes, the compressive moduli of scaffolds significantly decreased with increasing pore size. The altered surface characteristics were clearly reflected in the reduced water contact angles that meant a significant hydrophilization with the modified polymer surface. Electron spectroscopy for chemical analysis (ESCA) and time‐of‐flight secondary ion mass spectrometer (ToF‐SIMS) also confirmed the altered surface chemistry. When chondrocytes were seeded onto the AA‐grafted PLLA scaffolds, cell adhesion and proliferation were substantially improved as compared to the unmodified scaffolds. The benefit of the modified scaffolds was clear in the gene expressions of collagen type II that was significantly upregulated after 4‐week culture. Safranin‐O staining also identified greater glycosaminoglycan (GAG) deposition in the modified scaffold. The AA‐grafted porous polymer scaffolds were effective for cell adhesion and differentiation, making them a suitable platform for tissue‐engineered cartilage. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2008
Solubility, salivary sorption and degree of conversion of dimethacrylate‐based polymeric matrixes
Authors: Gonçalves Luana , Filho Jaime D. N. , Guimarães José G. A. , Poskus Laiza T. , Silva Eduardo M. 
Published: October 2007

AbstractThis study investigated the relationship between the solubility, salivary sorption, and degree of conversion of dimethacrylate‐based polymeric matrixes. Six polymeric matrixes produced by mixing bis‐GMA, TEGDMA and UDMA dimethacrylate monomers were studied. Photoactivation was induced by camphoroquinone/ethyl N,N‐dimethyl‐4‐aminobenzoate. The specimens were light‐cured using an irradiance of 850 mW/cm2 for 20 s. The solubility and sorption (μg/mm3) were measured after immersion in artificial saliva (neutral pH) for 7 days. The degree of conversion (%) was obtained by using a FT‐IR spectrometer equipped with an attenuated total reflectance crystal (ATR). The degree of conversion varied from 39.15 ± 6.30 to 65.57± 4.80, and was influenced by the viscosity of the monomers present in the polymeric matrixes. The solubility of polymeric matrixes varied between 13.64 ± 0.39 and 25.08 ± 0.83, and was strongly influenced by the degree of conversion (Pearson, r = −0.9587, p < 0.01). No correlation was found between salivary sorption and the degree of conversion (p = 0.3918). Salivary sorption was only dependent on the chemical and physical structures of the monomers presented in the polymeric matrixes. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2008
Synthesis and properties of waterborne polyurethane hydrogels for wound healing dressings
Authors: Yoo Hye‐Jin , Kim Han‐Do 
Published: October 2007

AbstractTo accomplish ideal wound healing dressing, a series of waterborne polyurethane (WBPU) hydrogels based on polyethylene glycol (PEG) were synthesized by polyaddition reaction in an emulsion system. The stable WBPU hydrogels which have remaining weight of above 85% were obtained. The effect of the soft segment (PEG) content on water absorbability of WBPU hydrogels was investigated. Water absorption % and equilibrium water content (%) of the WBPU hydrogel significantly increased in proportion to PEG content and the time of water‐immersion. The maximum water absorption % and equilibrium water content (%) of WBPU hydrogels containing various PEG contents were in the range of 409–810% and 85–96%, respectively. The water vapor transmission rate of the WBPU hydrogels was found to be in the range of 1490–3118 g/m2/day. These results suggest that the WBPU hydrogels prepared in this study may have high potential as new wound dressing materials, which provide and maintain the adequate moist environment required to prevent scab formation and dehydration of the wound bed. By the wound healing evaluation using full‐thickness rat model experiment, it was found that the wound covered with a typical WBPU hydrogel (HG‐78 sample) was completely filled with new epithelium without any significant adverse reactions. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2008
Local tissue reaction and differentiation of the prosthesis‐specific antibody response following functional implantation of vascular grafts in pigs
Authors: Zippel Roland , Wilhelm Lutz , Hoene Andreas , Walschus Uwe , Ueberrueck Torsten , Schlosser Michael 
Published: October 2007

AbstractThe study was aimed at investigating the local tissue reactions through a histological examination of β‐1‐integrin expression and neointima formation, and humoral immune responses by detection of prosthesis‐specific antibodies, after functional implantation of vascular prostheses. In three groups of pigs, the infrarenal aorta was replaced with segments of collagen‐impregnated Dacron®‐prostheses: M‐prosthesis—medium primary porosity, double velour layer, crimping; C‐prosthesis—low primary porosity, no velour, crimping; T‐prosthesis—high primary porosity, no velour, no crimping. For each prosthesis type, one series with four animals was used for examining the tissue reactions, and a second series with eight animals was used to study the antibody response, both until 116 days postoperative. In the first three weeks, the M‐prosthesis caused the highest tissue reactions and the highest antipolyester antibodies, but the lowest anticollagen antibodies, whereas the T‐prosthesis caused the highest anticollagen antibodies, but the least tissue response and antipolyester antibodies in the early phase. On day 116, the C‐prosthesis caused the highest tissue reactions and highest polyester‐specific antibodies. These results indicate a possible association between local inflammatory reactions and humoral immune responses, influenced by properties of vascular grafts. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2008
Comparison of cobalt chromium, ceramic and pyrocarbon hemiprostheses in a rabbit model: Ceramic leads to more cartilage damage than cobalt chromium
Authors: Jung Martin , Wieloch Peter , Lorenz Helga , Gotterbarm Tobias , Veyel Katrin , Daniels Mark , Martini Abdul Kader , Daecke Wolfgang 
Published: October 2007

AbstractCartilage wear after hemiarthroplasty remains a problem in orthopedic surgery. The main cause of cartilage wear, apart from incongruency of the joint partners, is generally considered to be the tribology of the material surfaces. This study evaluates in 27 rabbits the degree of cartilage wear of the tibia plateau after hemiarthroplasty with proximal interphalangeal prostheses made of three different materials [cobalt chromium (CoCr), pyrocarbon (PyCa), and ceramic (Cer)]. Three months after hemiarthroplasty, the articulating tibial cartilage was histomorphologically examined and degenerative damage was graded using the modified Mankin score. The mechanical capacity of the cartilage was assessed by stress relaxation testing. The biomechanical properties of the cartilage were significantly superior in the CoCr group as compared with the Cer group (p < 0.03), indicating less damage to the articulating cartilage surface. The Mankin score showed significantly lower values in the CoCr compared with Cer group (p = 0.011), whereas no differences were found between PyCa and CoCr or PyCa and Cer. In contrast to earlier reports, in this hemiarthroplasty model, the CoCr alloy showed less cartilage damage than a ceramic surface. Further, in vivo experiments are necessary to elucidate the controversial issue of the most suitable material for hemiarthroplasty. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2008
Saving cash: How to outnegotiate a leasing company
Authors: Contino Richard M. 
Published: October 2007

AbstractMany companies have a lot of cash tied up in leasing equipment. But there are ways to save a lot of money if you know how to outnegotiate a leasing company. The secret is to put together a comprehensive set of written bidding guidelines, reveals the author of this article. And he shows you how to do it. © 2007 Wiley Periodicals, Inc.
The lessons of Adelphia's cash fraud
Authors: Johnson Leigh Redd , Rudolph Holly R. 
Published: October 2007

AbstractBy using a complex centralized cash management system for Adelphia, John and Timothy Rigas systematically looted the company over a prolonged period. It was one of the most massive cases of corporate financial fraud to date. But what lessons does it teach us about cash management? © 2007 Wiley Periodicals, Inc.
Capital budgeting: Problems and new approaches
Authors: Sagner James S. 
Published: October 2007

AbstractCapital budgeting techniques using discounted cash flow calculate the present value of future flows, compared to the cash outflows or the investment required to fund a capital project. But companies are reluctant to commit funds to capital projects these days—probably because of disappointing past returns. The author explains current capital budgeting practices and reviews new approaches that may offer some solutions. He also offers a handy quick checklist for capital budgeting decisions. © 2007 Wiley Periodicals, Inc.
Integrated information systems: SAS 94 and auditors
Authors: Pathak Jagdish , Lind Mary R. 
Published: October 2007

AbstractStatement on Auditing Standards No. 94 (SAS 94) gives guidance to auditors on how IT impacts internal control—and it affects how auditors get their understanding of internal control and assess control risk. The authors discuss the background of these issues, describe the major changes of SAS 94, and give tips on implementing it. © 2007 Wiley Periodicals, Inc.
Increased adipogenesis of osteoporotic human‐mesenchymal stem cells (MSCs) characterizes by impaired leptin action
Authors: Astudillo Pablo , Ríos Susana , Pastenes Luis , Pino Ana María , Rodríguez J. Pablo 
Published: October 2007

AbstractThe bone marrow contains mesenchymal stem cells (MSCs) that differentiate to the osteogenic and adipogenic lineages. The fact that the decrease in bone volume of age‐related osteoporosis is accompanied by an increase in marrow adipose tissue implies the importance that the adipogenic process may have in bone loss. We previously observed that MSCs from control and osteoporotic women showed differences in their capacity to differentiate into the osteogenic and adipogenic pathways. In vitro studies indicate that bone marrow stromal cells are responsive to leptin, which increases their proliferation, differentiation to osteoblasts, and the number of mineralized nodules, but inhibits their differentiation to adipocytes. The aim of the present report was to study the direct effect of leptin on control and osteoporotic MSCs analyzing whether the protective effect of leptin against osteoporosis could be expressed by inhibition of adipocyte differentiation. MSCs from control, and osteoporotic donors were subjected to adipogenic conditions, in the absence or in the presence of 62.5 nM leptin. The number of adipocytes, the content of PPARγ protein, and mRNA, and leptin mRNA were measured by flow cytometry, Western blot, and RT‐PCR, respectively. Results indicate that control and osteoporotic MSCs differ in their adipogenic potential as shown by expression of active PPARγ protein. Leptin exerted an antiadipogenic effect only on control MSCs increasing the proportion of inactive phosphorylated PPARγ protein. Finally, results obtained during adipogenesis of osteoporotic cells suggest that this process is abnormal not only because of increased adipocyte number, but because of impaired leptin cells response. J. Cell. Biochem. 103: 1054–1065, 2008. © 2007 Wiley‐Liss, Inc.