bluuebunny/crossref_metadata_2025_split huggingface dataset:
Global sensitivity analysis of roof hazard factors based on information entropy and the surrogate model
Authors: Zhang Guowei , Ren Ting , Han Jun 
Published: February 2025

Abstract
The prevention and management of coal mine roof accidents remain challenging issues because it is difficult to evaluate and quantify the interaction effects of the disaster hazard factors objectively. This paper proposes a novel approach: combining information entropy and the surrogate model—and applies Sobol’s method, aiming to solve it and to obtain the hazard factors’ 1th and the global sensitivity value without human intervention. The results show that: (1) The complex logical relationships and interactions of roof hazard factors can be transformed into quantifiable numerical values by building a co-occurrence matrix of disaster factors and calculating its information entropy. (2) The sensitivity levels of roof hazard factors can be successfully distinguished and categorized into priority management and prevention or general management and prevention using the surrogate model and Sobol’s sensitivity method. The novel sensitivity analysis approach suggested in this study considers both the individual impacts of hazard factors and their interactions, offering a more thorough framework for risk assessment as well as a fresh perspective and tool for coal mine safety research.
Smooth muscle contractility of laser-enucleated prostate tissues and impacts of preoperative α1-blocker treatment in patients with and without catheterization
Authors: Keller Patrick , Hu Sheng , Berger Laurenz , Nicola Philip , Schierholz Felix , Tamalunas Alexander , Kale Oluwafemi E. , Weinhold Philipp , Waidelich Raphaela , Stief Christian G. , Hennenberg Martin 
Published: February 2025

Abstract
Prostate smooth muscle contraction is central in treatment of voiding symptoms in benign prostatic hyperplasia (BPH). Tissues from transurethral resection of the prostate (TURP) and radical prostatectomy (RP) for prostate cancer are widely used to study contractions. However, findings are limited by traumatization in TURP, and uncertain relationship to BPH in RP tissues. This study aims to examine contractions of laser-enucleated tissues. Tissues from holmium/thulium laser enucleation (HoLEP/ThuLEP) and TURP were contracted by KCl, noradrenaline and electric field stimulation (EFS) in an organ bath. Contractions were compared to RP tissues in previous studies. KCl-induced contractions averaged 2.5 mN, 0.7 mN and 3.3 mN in tissues from HoLEP/ThuLEP, TURP and RP, with non-responsive tissues included (2.4% HoLEP/ThuLEP, 37% TURP). Maximum EFS-induced contractions (Emax) averaged 47% of KCl in HoLEP/ThuLEP tissues, 27% in TURP tissues, and 68–235% in 21 previous studies with RP tissues. Emax values for noradrenaline averaged 99.7% in HoLEP/ThuLEP tissues, 56% in TURP tissues, and ranged from 92 to 260% in RP tissues. Preoperative α1-blocker treatment reduced EFS- and noradrenaline-induced contractions, and increased EC50 values for noradrenaline in laser-enucleated, catheterized patients, but not in patients without catheterization. Also, the ex vivo application of α1-blockers increased the EC50 values for noradrenaline and reduced Emax for EFS. Laser-enucleated tissues allow investigation of prostate smooth muscle contraction in medication-refractory voiding symptoms. Different impacts of preoperative α1-blocker treatment on ex vivo contractility in tissues from patients with and without catheterization point to clinically relevant heterogeneity of patients undergoing surgery for BPH.
Population attributable fraction of dietary risk factors for cancer mortality with a focus on gastrointestinal cancers in a population based cohort study
Authors: Moallemian Isfahani Marjan , Dalvand Sahar , Raei Dehaghi Nahid , Sharafkhah Maryam , Sepanlou Sadaf G. , Hashemian Maryam , Poustchi Hossein , Sadjadi Alireza , Roshandel Gholamreza , Khoshnia Masoud , Delavari Alireza , Rezaei Negar 
Published: February 2025

Abstract
Diet and nutrition are critical factors influencing cancer, the second leading cause of death worldwide. This study evaluated dietary risk factors and cancer mortality. 49,773 participants aged 40–75 years from the Golestan Cohort Study (GCS) were followed for a median of 15 years. Dietary intake was assessed using a validated food frequency questionnaire. Cox proportional hazard models estimated hazard ratios (HRs) and 95% confidence intervals (CIs), while population attributable fractions (PAFs) quantified the impact of reducing dietary risk factors. Low fruit intake accounted for 4.7% (95% CI: 0.5-8.7%) of all cancer deaths and 4.91% (95% CI: 0-9.85%) of male cancer deaths. It contributed to 23.5% (95% CI: 4.7-38.59%) of pancreatic cancer mortality in both sexes and 29.36% (95% CI: 5.15-47.38%) of male pancreatic cancer deaths. Low omega-3 intake increased esophageal and gastric cancer mortality risks, with PAFs of 21.65% (95% CI: 1.14-37.9%) and 21.46% (95% CI: 2.81-36.53%), respectively. In females, low omega-3 intake accounted for 38.68% (95% CI: 4.05-60.81%) of gastric cancer deaths. Low fruit and omega-3 consumption elevated cancer mortality risk. Community- and individual-level interventions are essential to enhance nutrient intake and reduce cancer mortality.
Evaluation of methylene blue restaining versus conventional hydrogen peroxide decolorization in immunohistochemical diagnosis of melanoma
Authors: Wan Weisong , Wang Le , Zeng Yuye , Hu Yuchang , Liu Yufei 
Published: February 2025

Abstract
This study seeks to address the challenge of melanoma identification in immunohistochemical (IHC) diagnosis, which is complicated by the similar coloration of melanin and DAB (Diaminobenzidine) staining, by introducing methylene blue counterstaining as an innovative solution. We compared the effectiveness of methylene blue counterstaining with that of the traditional hydrogen peroxide bleaching method in the diagnosis of melanoma. The study included 46 paraffin-embedded melanoma samples, and the staining efficacy for markers such as Melan A, HMB-45, PRAME, and Ki-67 was assessed via both methods. The results demonstrated that methylene blue counterstaining effectively converted the brownish-yellow melanin granules to a deep green color, significantly enhancing contrast and clarity with DAB staining. The average contrast and clarity scores for the methylene blue counterstaining method were 1.96 ± 0.21 and 1.91 ± 0.28, respectively, which were significantly greater than those of the conventional IHC group and the hydrogen peroxide bleaching group (P < 0.01). Furthermore, methylene blue counterstaining did not cause noticeable tissue damage or cellular morphology distortion, with tissue integrity scores comparable to those of the conventional IHC group (P > 0.05). Although the contrast and clarity also improved in the hydrogen peroxide bleaching group, it resulted in a significant decrease in tissue integrity (P < 0.01). This study is the first to apply methylene blue counterstaining in melanoma IHC analysis, demonstrating its advantages in enhancing staining quality, simplifying procedural workflows, and preserving antigenicity. This method provides a novel and effective tool for the pathological diagnosis of melanoma, potentially improving diagnostic accuracy and reliability.
Digital twin brain simulator for real-time consciousness monitoring and virtual intervention using primate electrocorticogram data
Authors: Takahashi Yuta , Idei Hayato , Komatsu Misako , Tani Jun , Tomita Hiroaki , Yamashita Yuichi 
Published: February 2025

Abstract
At the forefront of bridging computational brain modeling with personalized medicine, this study introduces a novel, real-time, electrocorticogram (ECoG) simulator, based on the digital twin brain concept. Utilizing advanced data assimilation techniques, specifically a Variational Bayesian Recurrent Neural Network model with hierarchical latent units, the simulator dynamically predicts ECoG signals reflecting real-time brain latent states. By assimilating broad ECoG signals from macaque monkeys across awake and anesthetized conditions, the model successfully updated its latent states in real-time, enhancing precision of ECoG signal simulations. Behind successful data assimilation, self-organization of latent states in the model was observed, reflecting brain states and individuality. This self-organization facilitated simulation of virtual drug administration and uncovered functional networks underlying changes in brain function during anesthesia. These results show that the proposed model can simulate brain signals in real-time with high accuracy and is also useful for revealing underlying information processing dynamics.
A deep learning-based system for automatic detection of emesis with high accuracy in Suncus murinus
Authors: Lu Zengbing , Qiao Yimeng , Huang Xiaofei , Cui Dexuan , Liu Julia Y. H. , Ngan Man Piu , Liu Luping , Huang Zhixin , Li Zi-Tong , Yang Lingqing , Khalid Aleena , Deng Yingyi , Chan Sze Wa , Tu Longlong , Rudd John A. 
Published: February 2025

Abstract
Quantifying emesis in Suncus murinus (S. murinus) has traditionally relied on direct observation or reviewing recorded behaviour, which are laborious, time-consuming processes that are susceptible to operator error. With rapid advancements in deep learning, automated animal behaviour quantification tools with high accuracy have emerged. In this study, we pioneere the use of both three-dimensional convolutional neural networks and self-attention mechanisms to develop the Automatic Emesis Detection (AED) tool for the quantification of emesis in S. murinus, achieving an overall accuracy of 98.92%. Specifically, we use motion-induced emesis videos as training datasets, with validation results demonstrating an accuracy of 99.42% for motion-induced emesis. In our model generalisation and application studies, we assess the AED tool using various emetics, including resiniferatoxin, nicotine, copper sulphate, naloxone, U46619, cyclophosphamide, exendin-4, and cisplatin. The prediction accuracies for these emetics are 97.10%, 100%, 100%, 97.10%, 98.97%, 96.93%, 98.91%, and 98.41%, respectively. In conclusion, employing deep learning-based automatic analysis improves efficiency and accuracy and mitigates human bias and errors. Our study provides valuable insights into the development of deep learning neural network models aimed at automating the analysis of various behaviours in S. murinus, with potential applications in preclinical research and drug development.
Drivers of critical metal enrichment in peralkaline magmas recorded by clinopyroxene zoning
Authors: Simpson Brenainn , Ubide Teresa , Spandler Carl 
Published: February 2025

Abstract
Highly sodic peralkaline magmas can reach hyper-enrichment in critical metals including rare earth elements (REE). We explore clinopyroxene zoning to track the evolution of peralkaline magmas and the mechanisms that trigger critical metal mineralisation, focusing on the Mesozoic Benolong Volcanic Suite in eastern Australia, which includes a zirconium + hafnium + niobium + tantalum mineralised subvolcanic sill. Major and trace element analysis of clinopyroxene across the volcanic field tracks continuous magma differentiation from diopside-hedenbergite to aegirine, associated with progressive enrichment of rare metals. Crucially, aegirine in the mineralised trachyte becomes sector-zoned and depleted in critical metals, which instead partition into latest-stage eudialyte. Association with vesiculated portions of the sill suggests that sector zoning is the product of undercooling which may be driven by degassing. Because volatiles increase the solubility of critical metals in silicate magmas, we suggest retention of volatiles and dynamic crystallisation conditions drive enrichment of critical metals in the Toongi deposit. Our data show that pyroxene chemistry and zoning can help track fertility in critical metals in peralkaline magmas.
Cyclopalladation of a covalent organic framework for near-infrared-light-driven photocatalytic hydrogen peroxide production
Authors: Rodríguez-Camargo Andrés , Terban Maxwell W. , Paetsch Martina , Rico Elio A. , Graf Daniel , Hirpara Radhika , Duppel Viola , Moudrakovski Igor , Etter Martin , Guijarro Néstor , Ochsenfeld Christian , Dinnebier Robert E. , Yao Liang , Lotsch Bettina V. 
Published: February 2025

Abstract
Covalent organic frameworks (COFs) have been developed as photosensitizers for photocatalytic energy conversion over the past decade; however, COF photocatalysts have yet to demonstrate the ability to harvest near-infrared light (above 760 nm, approximately 53% of the solar spectrum) for fuel or chemical conversion. In this work we introduce a post-synthetic functionalization strategy for COFs by incorporating a palladacycle directly into the COF backbone, extending the light absorption of an azobenzene-based COF into the near-infrared region. This approach enables homogeneous, atomically distributed palladium functionalization with a high loading of 12 wt% and without noticeable formation of palladium nanoparticles. The cyclopalladated COF, TpAzo-CPd, was used as a catalyst for photocatalytic hydrogen peroxide production under 810 nm illumination. This study demonstrates the use of COFs for near-infrared photocatalysis and opens the door to palladium-single-site COF catalysts for a wide range of chemical transformations.
Polarization aberrations in next-generation Giant Segmented Mirror Telescopes (GSMTs)
Authors: Ashcraft Jaren N. , Anche Ramya M. , Haffert Sebastiaan Y. , Hom Justin , Millar-Blanchaer Maxwell A. , Douglas Ewan S. , Snik Frans , van Holstein Rob G. , Van Gorkom Kyle , Skidmore Warren , Zhang Manxuan 
Published: February 2025

Context. Direct exo-earth imaging is a key science goal for astronomy in the next decade. This ambitious task imposes a target contrast of ≈10−7 at wavelengths from I to J-band. In our prior study, we determined that polarization aberrations can limit the achievable contrast to 10−5 to 10−6 in the infrared. However, these results assumed a perfect coronagraph coupled to a telescope with an ideal coating on each of the mirrors.
Aims. In this study we seek to understand the influence of polarization aberrations from segment-to-segment coating variations on coronagraphy and polarimetry.
Methods. We use the Poke open-source polarization ray tracing package to compute the Jones pupil of each GSMT with spatially- varying coatings applied to the segments. The influence of the resultant polarization aberrations is simulated by propagating the Jones pupil through physical optics models of coronagraphs using HCIPy.
Results. After applying wavefront control from an ideal adaptive optics system, we determine that the segment-to-segment variations applied limit the performance of coronagraphy to a raw contrast of approximately 10−8 in I-band, which is 2–3 orders of magnitude lower the target performance for high-contrast imaging systems on the ground. This is a negligible addition to the nominal polarization aberrations for ground-based systems. We further observe negligible degradation in polarimetric imaging of debris disks from segment-to-segment aberrations above and beyond the impact of nominal polarization aberration.
Früherkennung und -behandlung der Borderline-Persönlichkeitsstörung
Authors: Feurer Emanuel , Kaess Michael , Cavelti Marialuisa 
Published: February 2025

ZusammenfassungDie Borderline-Persönlichkeitsstörung (BPS) ist durch erhebliche Schwierigkeiten in der Impuls- und
Affektregulation sowie deutliche Auffälligkeiten im Selbstbild und in der Gestaltung von interpersonellen
Beziehungen charakterisiert. Bis heute ist die Meinung weitverbreitet, dass die BPS erst im
Erwachsenenalter diagnostiziert und behandelt werden kann. Demgegenüber stehen empirische Befunde, die
zeigen, dass sich die BPS in der Regel erstmals im Jugendalter manifestiert und bereits in dieser
Lebensphase zuverlässig diagnostiziert werden kann. Die frühzeitige Diagnosestellung ist Voraussetzung
für die Frühintervention, die darauf abzielt, negative Langzeitfolgen (wie z. B. Schulabbruch oder
soziale Isolation) für die betroffenen jungen Menschen zu verhindern. Dabei ist die Methode erster Wahl
die ambulante, störungsspezifische Psychotherapie.
Is(s)t mein Kind anders? Fütterstörungen in der Kinder- und
Jugendpsychiatrie
Authors: Martin Annick , Sant'Unione Sarah 
Published: February 2025

ZusammenfassungDieser Beitrag beschäftigt sich mit Diagnostik und Behandlung der frühkindlichen Fütterstörung, einem in
den verschiedenen Klassifikationssystemen unscharf und unterschiedlich repräsentierten Störungsbild. Aus
kinder- und entwicklungspsychiatrischer Sicht werden Ätiologie und Vorgehensweise geschildert. Hierbei
ist der pädiatrische Blick zur Mitbeurteilung differentialdiagnostisch zu bedenkender somatischer
Faktoren unabdingbar. Ein integratives Behandlungsvorgehen mit individueller Planung unter Einbezug
verschiedener Fachrichtungen im multidisziplinären Team ist für den Behandlungserfolg entscheidend.
Environmental Hazards and Male Fertility: Why Don't We Know More?
Authors: Mitsunami Makiko , Hart Jaime E. , Chavarro Jorge E. 
Published: February 2025

AbstractNearly all (97%) the studies in the recent literature addressing the relationship between environmental hazards and male fertility use at least one of three common study design strategies: recruiting men presenting to fertility centers (53%), evaluating only one environmental exposure at a time (87%), and using conventional semen quality parameters as the only study outcome (45%). While each of these study design features is logical, defensible, and has generated an enormous amount of information regarding the impact of the environment on male reproductive function, they may also be barriers to furthering our understanding. In this article, we examine in which ways each of these study design features limits progress on male fertility research and propose strategies to go beyond them. Rather than abandoning these strategies, we propose that they should be a starting point instead of the default strategy for the future of male fertility research to more fully understand how men's environmental exposures impact human fertility and human reproduction more generally.
Strong parity-violation effects induced by large-amplitude motions: A quantum-dynamics study of substituted chiral methanols
Authors: Sunaga Ayaki 
Published: February 2025

An enhanced mechanism is proposed for the large-amplitude-motion-induced parity-violating frequency by integrating the exact quantum dynamics method with the relativistic electronic structure theory. The torsional wavefunctions and parity-violating (PV) frequency shifts are obtained by using the exact quantum dynamics method. The potential energy curve and PV energy along the torsional coordinates are calculated using the extended atomic mean-field two-component Hamiltonian. The predicted PV frequency shift for the torsional transition of CFClBrOH is ∼100 times larger than that of the conventional C–F stretching mode of CHFClBr. The maximum PV frequency shift (3.2 Hz) is obtained in the CHBrIOH molecule.
The vibrational wavepackage dynamics and phase modulation via the resonant Rydberg states in molecules
Authors: Cao Ling , Wang Yanmei , Wei Jie , Song Xinli , Zhang Song 
Published: February 2025

The observation of vibrational coherence has become significant because it reflects the spatial and temporal localization of a nucleus in a specific mode and characterizes energy flow and multiple kinetic relaxations in chemical dynamics. Vibrational coherence in the S1 state of 2,4-difluoroanisole has been investigated in real time by femtosecond time-resolved photoelectron spectroscopy and time-of-flight mass spectroscopy. Quantum beats of superpositions exhibit temporal oscillations with a frequency of 78 cm−1. Combining the structure computations, oscillations derive from the structure change from planar to nonplanar geometry, which correspond the coherence wavepackets moving from the Franck–Condon region toward the minimum point of the potential energy surface, elucidating the energy flows following the excitation of 2,4-difluoroanisole in the S1 state. The phases of the quantum beat via the resonant Rydberg states exhibit a shift of π rad. The vibrational coherent phase modulation via the resonant Rydberg states will facilitate the chemical coherence control in complex molecular systems.
A multi-modal approach to enhance Toxoplasma gondii detection in the Australian landscape
Authors: Breidahl Amanda Jane , Lynch Michael , Sutherland Duncan R. , Traub Rebecca , Hufschmid Jasmin 
Published: February 2025

Context The disease toxoplasmosis, caused by infection with the intra-cellular protozoan parasite Toxoplasma gondii, is a potential threat to the conservation of some endothermic vertebrates. Toxoplasmosis has been reported to cause disease and acute death in many marsupials, including endangered bandicoots. Methods are required to quantify the environmental contamination with T. gondii and, hence, assess the relative threat it poses to resident species. A multi-modal approach to assess an environment for the presence of pathogens increases the likelihood of a more accurate estimate of the level of contamination and inferred risk of infection to target species. Aim This project aimed to use a multi-modal approach to estimate the environmental contamination with T. gondii across two separate landscapes with differing cat populations in the northern hinterland of Western Port, Victoria, Australia. Methods The following four parameters were used: the presence of IgG antibodies to T. gondii in free-ranging southern brown bandicoots (Isoodon obesulus) using the modified agglutination test (MAT); the presence of T. gondii DNA in the tissues of free-ranging rabbits (Oryctolagus cuniculus) and mice (Mus musculus) by real-time quantitative polymerase chain reaction (qPCR); and the presence of T. gondii oocysts in the soil using filtration methods and real-time qPCR. Key results Toxoplasma gondii was not identified in any of the soil samples (n = 594), southern brown bandicoots (n = 24) or mice (n = 267). Only one rabbit tested positive for T. gondii (n = 118). Conclusions The tests across soils and three different mammalian species all delivered similar results, leading to the conclusion that the landscapes measured had low T. gondii contamination at the time of assessment. Implications This Australian study is the first to show that the use of pathogen detection in target and two sentinel species, combined with soil analysis, may be a useful approach to assess the environmental risk of T. gondii infection in endangered and vulnerable species. Further research is recommended across sites with a gradient of T. gondii contamination and into the use of other sentinel species. Further refining of techniques for direct soil analysis in Australian conditions is recommended.