bluuebunny/crossref_metadata_2025_split huggingface dataset:
Duloxetine and Cognitive Behavioral Therapy with Phone-based Support for the Treatment of Chronic Musculoskeletal Pain: Study Protocol of the PRECICE Randomized Control Trial
Authors: Ang Dennis C , Davuluri Swetha , Kaplan Sebastian , Keefe Francis , Rini Christine , Miles Christopher , Chen Haiying 
Published: April 2024

Abstract
Background: Chronic musculoskeletal pain (CMP) is the most common, disabling, and costly of all pain conditions. While evidence exists for the efficacy of both duloxetine and web-based cognitive behavioral therapy (CBT) as monotherapy, there is a clear need to consider study of treatment components that may complement each other. In addition, given the reported association between patient’s adherence and treatment outcomes, strategies are needed to enhance participant’s motivation to adopt and maintain continued use of newly learned pain coping skills from CBT.
Methods: Two hundred eighty participants will be recruited from the primary care clinics of a large academic health care system in North Carolina. Participants with CMP will be randomized to one of 3 treatment arms: (1) combination treatment (duloxetine + web-based self-guided CBT) with phone-based motivational interviewing (MI), (2) combination treatment without phone-based MI and (3) duloxetine monotherapy. Participants will be in the study for 24 weeks and will be assessed at baseline, week 13, and week 25. The primary outcome is the Brief Pain Inventory (BPI)-Global Pain Severity score, which combines BPI pain severity and BPI pain interference. Secondary measures include between-group comparisons in mean BPI pain severity and BPI pain interference scores. Data collection and outcome assessment will be blinded to treatment group assignment.
Discussion: This randomized controlled trial (RCT) will determine if combination treatment with duloxetine and web-based CBT is superior to duloxetine monotherapy for the management of CMP. Furthermore, this RCT will determine the effectiveness of phone-based motivational interviewing in promoting the continued practice of pain coping skills; thereby, enhancing treatment outcomes.
Trial Registration: NCT04395001. Registered in ClinicalTrials.gov on May 15, 2020.
Origami-Inspired 3D Opto-Electro Array for Optogenetic Neuromodulation and Neurophysiology Recording
Authors: Li Wen , Gong Yan , Liu Xiang , Jiang Zebin , Weber Arthur 
Published: April 2024

Abstract
This paper presents a thin-film, three-dimensional (3D) opto-electro array featuring four addressable microscale light-emitting diodes (LEDs) for surface cortex illumination and nine penetrating electrodes for simultaneous recording of light-evoked neural activities. Inspired by the origami concept, we have developed a meticulously designed "bridge+trench" structure that facilitates the transformation of the array from 2D to 3D while preventing damage to the thin film metal. Prior to device transformation, the shape and dimensions of the 2D array can be customized, enhancing its versatility for various applications. In addition, the arched base offers strong mechanical support to facilitate the direct insertion of the probe into tissue without any mechanical reinforcement. The array was encapsulated using polyimide and epoxy to ensure mechanical flexibility and biocompatibility of the device. The efficacy of the device was evaluated through comprehensive in vitro and in vivo characterization.
Longitudinal cervicovaginal microbiome and virome alterations during ART and discordant shedding in women living with HIV
Authors: Kaelin Emily A. , Mitchell Caroline , Soria Jamie , Rosa Alberto La , Ticona Eduardo , Coombs Robert W. , Frenkel Lisa M. , Bull Marta E. , Lim Efrem S. 
Published: April 2024

Abstract
Despite successful suppression of plasma HIV replication by antiretroviral therapy (ART), some women living with HIV (WLHIV) can still experience genital HIV shedding (discordant shedding). Female genital tract (FGT) microbiome and virome dynamics during long-term ART in WLHIV are poorly understood but might contribute to discordant HIV shedding, as the microbiome and virome are known to influence FGT health. To understand FGT microbial communities over time during ART usage and discordant shedding, we characterized the microbiome and virome in 125 cervicovaginal specimens collected over two years in 31 WLHIV in Lima, Peru. Intrapersonal bacterial microbiome variation was higher in HIV shedders compared to non-shedders. Cervicovaginal virome composition changed over time, particularly in non-shedders. Specifically, anellovirus relative abundance was inversely associated with ART duration and CD4 counts. Our results suggest that discordant HIV shedding is associated with FGT microbiome instability, and immune recovery during ART influences FGT virome composition.
Is the Usefulness of Accruals Superior to Real Income? Evidence from the Palestine Exchange
Authors: Abdelkarim Naser , Turshan Mohammad , Daraghma Zahran 
Published: April 2024

Abstract
This research examines the value relevance of real profit using Economic Value Added (EVA) as a proxy versus accounting outcomes. The question at hand is whether the usefulness of real income numbers is superior to accruals (traditional performance indicators) for Palestinian corporations. This research utilized an experimental research design to gather panel data from the reported annual data of 31 non-financial listed corporations on the PEX from 2015 to 2019. Descriptive statistics and the Jarque–Bera test were used, along with a Nonparametric Spearman's rho Correlations test to evaluate linear relationships between variables. The Random Effect Model (REM) was used based on the Correlated Random Effects - Hausman Test to establish a concrete research model. The findings demonstrate that the market values of shares have a strong relationship with traditional measures, where the relative informativeness ability of accounting indicators is greater than the informativeness ability of real income. The study suggests using EVA as a supplement, not a replacement, for the current traditional accounting performance measurements. Future studies can compare the effect of real income and accounting indicators on a variable other than stock market value. As a policy implication, we advise users in Palestine to consider accruals but economic income indicators as supplementary. This paper is the first in Palestine to use advanced econometric analysis that establishes concrete findings about the conflict between Accounting-Based versus Economic-Based indicators.
Effects of the Ligand Linkers on Stability of Mixed-Valence Cu(I)Cu(II) and Catalytic Aerobic Alcohol Oxidation Activity
Authors: Jehdaramarn Attawit , Chantarojsiri Teera , Worakul Thanapat , Surawatanawong Panida , Chainok Kittipong , Sangtrirutnugul Preeyanuch 
Published: April 2024

Abstract
We synthesized a class of ligands that feature single (L1) and dual amine-bis(triazole) chelates (L2 with a 1,3-phenylene linker and L3 with a 1,5-naphthalene linker). Our findings which were derived from UV-Vis titrations, crystal structure analysis of relevant copper complexes, and DFT calculations indicate the formation of both mononuclear CuBr(L1) and dinuclear (µ-Ln)(CuBr)2 (Ln = L2 and L3) complexes. The catalytic activities of CuBr/Ln, in combination with TEMPO (2,2,6,6-tetramethylpiperidin-1-yl)oxyl) co-catalyst and NMI (N-methylimidazole) for aerobic alcohol oxidation, reveal the following activity trend: CuBr/L3 > CuBr/L2 > CuBr/L1. Furthermore, electrochemical data from in-situ generated CuBr complexes suggest that the higher catalytic performance of CuBr/L3 is attributed to the presence of less stable mixed-valence and more reducible Cu(I)-L3-Cu(II) species compared to Cu(I)-L2-Cu(II). This difference is a result of weaker σ interactions between Cu–Namine, larger bridging π systems, and a longer Cu···Cu distance in the presence of L3. Additionally, the catalyst system, CuBr/L3/TEMPO/NMI, efficiently promotes the aerobic oxidation of benzyl alcohol to benzaldehyde at room temperature in CH3CN with a high turnover frequency (TOF) of 39 h− 1 at 1 h.
Biopolymer-based sustainable Internet of Things for smart homes
Authors: Lebedev Vladimir , Lebedeva Katerina , Cherkashina Аnna , Voronkin Andrij , Kopach Volodymyr , Petrushenko Sergey , Fedonenko Alina , Klochko Natalja 
Published: April 2024

Abstract
In the infrastructure of the future, based on intelligent computerized systems and control and monitoring devices, the smart home is part of the Internet of Things (IoT). However, in addition to the need to address energy consumption, the widespread adoption of smart homes may also exacerbate the growing problem of increasing amounts of non-recyclable e-waste from IoT devices. Compared to synthetic plastics, biopolymers offer many unique advantages such as robust structure, light weight, mechanical flexibility, biocompatibility, biodegradability and renewability. Biopolymers, which are abundant in natural products such as cellulose, silk fibroin, polylactic acid, chitosan, collagen, keratin, alginate, starch and gelatin, have great promise for the production of environmentally friendly Internet of Things devices. They are ideal candidates for the use of low-temperature sol-gel coating and ink-printing processes to facilitate the development of low-cost, large-area flexible electronic devices. This work presents developments known from the literature, as well as the results of original research on the use of biopolymer materials to create flexible, wearable and textile electronic devices, such as sensors, energy storage devices and nanogenerators, soft hydrogel actuators and wireless communication devices that are promising for the Internet of Things but have not yet been implemented in smart homes.
GC-MS Profiling of Tinospora cordifolia (Giloy) stem extract for identification of antifungal compounds against Macrophomina phaseolina causing dry root rot of Mungbean [Vigna radiata (L.) Wilczek]
Authors: Gupta Prince Kumar , Kaur Manpreet , Chitara Manoj Kumar , Mishra Dhruv , Kushwaha K.P.S. 
Published: April 2024

Abstract

Macrophomina phaseolina, a necrotrophic fungus causes multiple diseases in mungbean and other economically important crops throughout the world. The pathogen remains in soil or crop residues for up to 3 years as microsclerotia. To search for an alternative to current conventional practices against diseases that are limited and are associated with toxicity and resistance. The application of medicinal plant extracts has shown enormous antifungal potential against many sclerotial-forming phytopathogens. In the present study, a total of five concentrations (10, 20, 30, 40, and 50%) of ten different medicinal plant extracts were tested against the per cent mycelial inhibition of M. phaseolina under in-vitro conditions. The results revealed that all the plant extracts showed significant mycelial inhibition at all concentrations over the check. The maximum per cent mycelial inhibition was recorded in giloy (70.5%) followed by curry leaf (60.7%) which was at par with eucalyptus (56.0%) followed by lemon grass (50.8%) and bhang (46.5%) at 50% concentration. Maximum, total phenol (291 mg GAE/g) and flavonoid (179 mg QE/g) content exhibited in giloy. The qualitative analysis of plant extracts indicates the presence of flavonoids, alkaloids, phenols and proteins. GC-MS analysis of the giloy (Tinospora cordifolia) showed the presence of 32 phytochemical compounds, whereas cyclopentadecanone was the predominant compound with 28.45% peak area followed by 2- bromododecane (25.93%), palmitic acid, TMS derivative (10.78%), 2-hexadeccen-1-ol,3,7,11,15-tetramethyl (5.04%), 2-hexadecen-1-ol, 3,7,11,15-tetramethyl (5.04%), tetracosane (4.88%), hexanoic acid, 4-hexadecyl ester (4.12) and butylated hydroxytoluene (0.79%). Some of these major compounds might be responsible for the antifungal properties of Tinospora cordifolia against M. phaseolina.
Unraveling the Genetic Links Between Plasma Lipidome and Ankylosing Spondylitis: Insights from a Two-Sample Mendelian Randomization Approach
Authors: Wu Jun , Wei Pinghua , Ding ZhaoHui , Nie HeYun , Liu YunFeng 
Published: April 2024

Abstract
Background: Emerging epidemiological evidence indicates an association between Plasma Lipidome and Ankylosing Spondylitis (AS), yet our grasp of the underlying genetic and causative links remains nascent. This study endeavors to unravel the genetic interplay and assess the causality within this association.
Methods: This investigation utilized a two-sample Mendelian Randomization (MR) technique to discern the causal dynamics between lipid profiles and AS. To ascertain causal relationships among 179 distinct lipid molecules and AS susceptibility, we capitalized on extensive GWAS data. The primary analytical tool was the inverse variance weighted (IVW) method, complemented by MR Egger, weighted median, Weighted mode, and Simple mode analyses to ensure comprehensiveness. To assess result consistency, the Cochrane Q-test gauged heterogeneity and the MR-Egger intercept test, alongside MR-PRESSO, scrutinized for horizontal pleiotropy. Lastly, a leave-one-out sensitivity analysis authenticated the findings' stability.
Results: The results indicated that levels of Sterol ester (27:1/18:0), Sterol ester (27:1/18:2), Phosphatidylethanolamine (18:1_0:0), Phosphatidylcholine (16:1_18:1), Phosphatidylcholine (16:1_20:4), Phosphatidylcholine (17:0_18:2), Phosphatidylcholine (18:0_20:3), Phosphatidylcholine (18:0_22:6), Phosphatidylcholine (O-16:0_20:4), Phosphatidylcholine (O-18:1_18:2), Phosphatidylinositol (18:1_18:2), Triacylglycerol (50:3), Triacylglycerol (54:3), and Triacylglycerol (56:8) were genetically predicted as consequences of AS. There was no evidence of horizontal pleiotropy or heterogeneity between the genetic variants (P>0.05), and a leave-one-out test confirmed the stability and robustness of this association.
Conclusion: Our study deepens the understanding of the genetic research into the close connection between lipid levels and AS, providing guidance for future clinical and basic research.
Prognostic role of hybrid PET/MRI in patient with Dasatinib-Induced Pulmonary Hypertension：A Case Report
Authors: Ji Yanjun , Ding Lijun , Zhang Chen , Ding Wei , Cao Huixiao 
Published: April 2024

Abstract
Cancer drug therapies are associated with various cardiovascular complications, among which pulmonary hypertension (PH) has received increasing attention in recent years. Previous studies have demonstrated a link between 18 F-fluorodeoxyglucose (18 F-FDG) uptake and the progression of PH. We report the case of a 26-year-old female with a 33-month history of acute lymphoblastic leukemia (ALL) treated with dasatinib for 23 months. Ten months ago, the patient presented with symptoms of pulmonary hypertension and dasatinib was discontinued immediately. To further investigate the condition, the multimodal 18 F-FDG positron emission tomography / magnetic resonance (PET/MR) imaging was performed. It revealed manifestations consistent with PH from multiple morphological, functional and metabolic perspectives. The SUV RV / SUV LV and RVEF suggested a favorable prognosis. We can preliminarily infer that the pulmonary hypertension in this patient is related to dasatinib and is reversible, and the use of cardiac PET/MR imaging plays an indispensable role in early diagnosis and prognosis prediction.
In-vivo parcellation of human subcortex by multi-modal MRI
Authors: Ali Tonima , Lv Jinglei , Kassem Mustafa , D'Souza Arkiev , O’Callaghan Claire , Dalton Marshall , Calamante Fernando 
Published: April 2024

Abstract

Human subcortical grey matter (SGM) structures are crucial hubs for processing, transmitting and modulating brain-wide signals. However, in-vivo characterisation of subnuclei within the SGM structures remains limited, restricting our knowledge of their roles in brain function and in disorders. To address this gap, we introduce the Sydney Subcortical Gray Matter (SydSGM) parcellation— based on a novel data-driven approach using multiple MRI contrasts to assess myelination, directionality of white matter fibres, and diffusion micro-environment. Fifty-four distinct parcels were identified across caudate, putamen, globus pallidus, nucleus accumbens, and thalamus based on the coherent representation of these attributes, which demonstrated remarkable concordance with histology-based delineations. The SydSGM parcellation now facilitates detailed structural connectivity analysis at the subnuclei scale. It can be adopted as a standalone atlas or incorporated into existing brain atlases. We demonstrate SydSGM parcellation’s advantage by revealing declined structural connectivity of highly resolved SGM subnuclei in patients with early Parkinson’s disease.
CO2 capture using boron, nitrogen, and phosphorus-doped C20 in the present electric field: A DFT study
Authors: Rezaee Parham , Asl Shervin Alikhah , Javadi Mohammad Hasan , Rezaee Shahab , Morad Razieh , Akbari Mahmood , Arab Seyed Shahriar , Maaza Malik 
Published: April 2024

Abstract
Burning fossil fuels emits a significant amount of CO2, causing climate change concerns. CO2 Capture and Storage (CCS) aims to reduce emissions, with fullerenes showing promise as CO2 adsorbents. Recent research focuses on modifying fullerenes using an electric field. In light of this, we carried out DFT studies on some B, N, and P doped C20 (C20-nXn, n = 0, 1, 2, and 3; X = B, N, and P) in the absence and presence of an electric field in the range of 0-0.02 a.u.. The cohesive energy was calculated to ensure their thermodynamic stability showing, that despite having lesser cohesive energies than C20, they appear in a favorable range. Moreover, the charge distribution for all structures was depicted using the ESP map. Most importantly, we evaluated the adsorption energy, height, and CO2 angle, demonstrating the B and N-doped fullerenes had the stronger interaction with CO2, which by far exceeded C20's, improving its physisorption to physicochemical adsorption. Although the adsorption energy of P-doped fullerenes was not as satisfactory, in most cases, increasing the electric field led to enhancing CO2 adsorption and incorporating chemical attributes to CO2-fullerene interaction. The HOMO-LUMO plots were obtained by which we discovered that unlike the P-doped C20, the surprising activity of B and N-doped C20s against CO2 originates from a high concentration of the HOMO-LUMO orbitals on B, N and neighboring atoms. In the present article, we attempt to introduce more effective fullerene-based materials for CO2 capture as well as strategies to enhance their efficiency and revealing adsorption nature over B, N, and P-doped fullerenes.
Optimizing the OFDM Radar Waveform for Low-Angle Target Tracking Using WAF Criteria
Authors: Asadsangabi Zohreh , Mohseni Reza , Samadi Sadegh 
Published: April 2024

Abstract

A novel algorithm is proposed to enhance the wideband ambiguity function (WAF) of radar by designing an orthogonal frequency division multiplexing (OFDM) waveform. This design improves signal resolution, leading to more accurate tracking of low-angle targets. The goal is to optimize the volume of the OFDM signal's WAF to approximate the desired ambiguity function volume in the delay-Doppler plane. This optimized waveform improves the delay (range) resolution of the radar system by enhancing the auto-correlation function (ACF). Additionally, using a multicarrier OFDM signal improves delay resolution by the number of subcarriers. The phase and amplitude coding technique further improves delay and Doppler. It is important to note that the waveform design considers various factors that affect low-angle target tracking, such as atmospheric attenuation, surface reflection, diffraction, and refraction. Theoretical expressions for each area, along with tabular and graphical results applicable to common radar frequencies and radar-target paths, are provided. When modeling specular multipath signals, the effects of the earth's curvature and the linear refractivity gradient of the horizontally stratified atmosphere are also taken into account. The methodology used is the LSE method utilized in designing the waveform. The main results obtained demonstrate enhancements not only in the Doppler and delay ambiguity function, but also in angle measurement and RMSE. Finally, our work demonstrates improved performance when compared with the articles.
Dysfunction of heat shock factor 4 impairs retinal structure and visual function in mice and zebrafish
Authors: Liu Baixue , lang Youfei , Xue Meng Jiao , Jiang Ming Jun , Jia Xiao lin , Chen Dandan , ZHou Guilinng , Zhang Fengyan , Peng Xueyan , Hu Yanzhong 
Published: April 2024

Abstract

Purpose
Loss of function of heat shock factor 4(HSF4) causes microphthalmia with lens opacification. The objective of this study is to uncover the regulation of HSF4 on retinal homeostasis.
Methods
Hsf4del mutant mice and Hsf4null zebrafish models were recruited in this study. H&E was used to determine retinal structure. The immunoblot, qRT-PCR and immunofluorescence staining were used to measure the expression of mRNA and protein. AAV2-Hsf4-Flag virus were used to the reconstitution assay.
Results
The retinal structure of Hsf4del mice and Hsf4null zebrafish, which is comparable to wild-type at P10 days old, undergoes atrophy at 7 and 13 months old. Dysfunction of Hsf4 downregulates the expression of visual cycle enzymes (e.g., RPE65, RLBP1 and RDH5 ) and heat shock proteins (e.g., HSP90 and HSP25), and simultaneously activates retinal gliosis (e.g., upregulating the expression of GFAP, GS, CRYAB, inflammatory interleukins, and VEGFA) and the expression of senescent P16INK4a and P21cip1 in the retina of postnatal P1- P10 mice and embryonic zebrafish, and those changes are enhanced in 7 and 13 months old mice and zebrafish. Subretinal administration of AAV2-Hsf4b to the retina of one-month Hsf4del mice partially rescued the expression of changed proteins. ERG results showed that the downregulation of amplitude of a- and b- waves at scotopic response was detected at P15. Overexpression of Flag-Hsf4b in the in vitro cultured primary Hsf4del RPE cells restores the expression of visual cycle enzymes and heat shock proteins. TUNEL assay shows that there are more apoptotic cells in the ONL and the RPE of 7-and 13-month-Hsf4del retina than in P10 retina.
Conclusion
In addition to causing cataracts, the loss of function of HSF4 impairs the visual cycles and activates the gliosis in early postnatal age, which are associated with the retinal atrophy.