bluuebunny/crossref_metadata_2025_split huggingface dataset:
Indications for Nonbiological Reconstruction of Posttraumatic Bone Defects About the Knee
Authors: Tetsworth Kevin D. , Welyczko Zhenya H. , Quinnan Stephen M. 
Published: March 2024

Summary:
3D printing and modeling has continued to grow in popularity over the past decade because the technology has matured and become more affordable and widely available. The main indications for nonbiological reconstruction of large bone defects are principally those patients where the candidate is unlikely to be successful if reconstructed by other means. Bespoke, custom, patient-specific implants can be designed to very effectively address bone loss, incorporating design elements that are particular to the needs of any given unique clinical condition. These implants are generally designed as titanium scaffolds that encourage bony incorporation at the host implant junction both proximal and distal. These scaffolds are typically considered a cellular solid, with high porosity that also promotes bone ingrowth directly into the substance of the body of the implant. Titanium scaffolds of this type have become a useful treatment alternative for large segmental bone defects around the knee, especially distal femoral defects. These are often adult patients with local or systemic compromise, or instead they may be too young to be considered candidates for reconstruction using a megaprosthesis. The process requires careful evaluation of individual patients, then matching that patient with the best treatment option, while recognizing the expectations and demands specific to that particular patient. Several cases are presented here to illustrate the variety of indications that can be successfully addressed with this technology, highlighting the quality of the clinical outcome that can be achieved despite the complexity of the pathology encountered.
The influence of pain and kinesiophobia on motor control of the upper limb: how pointing task paradigms can point to new avenues of understanding
Authors: Duport Arnaud , Morel Pierre , Léonard Guillaume , Devanne Hervé 
Published: March 2024

AbstractPeople experiencing kinesiophobia are more likely to develop persistent disabilities and chronic pain. However, the impact of kinesiophobia on the motor system remains poorly understood. We investigated whether kinesiophobia could modulate shoulder pain–induced changes in (1) kinematic parameters and muscle activation during functional movement and (2) corticospinal excitability. Thirty healthy, pain-free subjects took part in the study. Shoulder, elbow, and finger kinematics, as well as electromyographic activity of the upper trapezius and anterior deltoid muscles, were recorded while subjects performed a pointing task before and during pain induced by capsaicin at the shoulder. Anterior deltoid cortical changes in excitability were assessed through the slope of transcranial magnetic stimulation input–output curves obtained before and during pain. Results revealed that pain reduced shoulder electromyographic activity and had a variable effect on finger kinematics, with individuals with higher kinesiophobia showing greater reduction in finger target traveled distance. Kinesiophobia scores were also correlated with the changes in deltoid corticospinal excitability, suggesting that the latter can influence motor activity as soon as the motor signal emerges. Taken together, these results suggest that pain and kinesiophobia interact with motor control adaptation.
Virtual Reality Simulation in a Health Assessment Laboratory Course
Authors: Vihos Jill , Chute Andrea , Carlson Sue , Shah Mamta , Buro Karen , Velupillai Nirudika 
Published: March 2024

Background:
The purpose of this mixed-methods study was to examine the relationship between virtual reality simulation (VRS) and student satisfaction and self-confidence in a health assessment laboratory course.

Methods:
Second-year students (n = 37) completed a postoperative respiratory distress scenario using Elsevier’s Simulation Learning System with Virtual Reality. All participants completed the Satisfaction and Self-Confidence in Learning Scale; a subset participated in 1:1 semistructured interviews.

Results:
Satisfaction and self-confidence scores were strongly correlated. VRS experiences of fidelity, communication confidence and competence, learning with peers, integrated learning and critical thinking, and a safe space to learn were related to students’ satisfaction and self-confidence.

Conclusions:
VRS experiences are correlated with high student satisfaction and self-confidence.
A Retrospective Analysis of 10-year Experience on Branched and Fenestrated Endovascular Aortic Arch Repair
Authors: Rohlffs Fiona , Nana Petroula , Panuccio Giuseppe , Torrealba Jose I. , Tsilimparis Nikolaos , Rybczynski Meike , Detter Christian , Kölbel Tilo 
Published: March 2024

Objective:
This study aimed to present the early and mid-term outcomes of fenestrated/branched thoracic endovascular aortic repair (f/bTEVAR) for aortic arch pathologies.

Background:
f/bTEVAR represents a less invasive treatment option for aortic arch diseases. Previous published series showed decreased early mortality and morbidity compared to open repair.

Methods:
A single-center retrospective analysis of consecutive patients, managed with f/bTEVAR (Cook Medical, Bloomington, IN, USA) between 01.09.11and 30.06.22 was conducted. Primary outcomes were technical success, 30-day mortality and stroke. Data during follow-up and factors affecting early mortality and stroke were analyzed.

Results:
209 patients were included (38.3% females; mean age 69.8±3.4years; mean aortic diameter 61±4.7 mm); 14.4% were managed urgently. Fenestrations/scallop configuration was used in 39.7%, branched devices in 55.5% and branch/scallop combination in 4.8%. Landing to zone 0 was performed in 65.5% and in zone 1 in 32.1%. Non-native aortas were used for landing in 39.2%. Technical success was 97.1% and 30-day mortality 9.5%. Strokes were identified in 10%; 5.7% major. Non-native proximal aortic landing zone was an independent protective factor for stroke (P=0.002). Post-operative stroke (P<0.001) and pericardial effusion (P<0.001) were independently related to 30-day mortality. The mean follow-up was 21±8 months. The estimated survival and freedom from reintervention rates were 79.5% (standard error; SE3.1%) and 47.1% (SE 4.3%) at 24months, respectively.

Conclusions:
f/bTEVAR presented high technical success and acceptable 30-day mortality. Non-native proximal landing zone was related to lower stroke rate. Half of patients needed a reintervention within the 24-month follow-up.
The Increasing Burden of Emergency Department and Inpatient Consultations for “Papilledema”
Authors: Ray Hetal J. , Okrent Smolar Avital Lily , Dattilo Michael , Bouthour Walid , Berman Gabriele , Peragallo Jason H. , Kedar Sachin , Pendley Andrew M. , Greene James G. , Keadey Matthew T. , Wright David W. , Bruce Beau B. , Newman Nancy J. , Biousse Valérie 
Published: March 2024

Background:
Increasing incidence of idiopathic intracranial hypertension (IIH), overreported radiologic signs of intracranial hypertension, difficult access to outpatient neuro-ophthalmology services, poor insurance coverage, and medicolegal concerns have lowered the threshold for emergency department (ED) visits for “papilledema.” Our objective was to examine referral patterns and outcomes of neuro-ophthalmology ED and inpatient consultations for concern for papilledema.

Methods:
At one university-based quaternary care center, all adults referred for “papilledema” over one year underwent a standardized ED “papilledema protocol.” We collected patient demographics, final diagnoses, and referral patterns.

Results:
Over 1 year, 153 consecutive patients were referred for concern for papilledema. After papilledema protocol, 89 of 153 patients (58%) had bilateral optic disc edema, among whom 89% (79/89) had papilledema (intracranial hypertension). Of the 38 of 153 (25%) consultations for suspected disorder of intracranial pressure without previous fundus examination (Group 1), 74% (28/38) did not have optic disc edema, 21% (8/38) had papilledema, and 5% (2/38) had other causes of bilateral disc edema. Of the 89 of 153 (58%) consultations for presumed papilledema seen on fundus examination (Group 2), 58% (66/89) had confirmed papilledema, 17% (15/89) had pseudopapilledema, and 9% (8/89) had other causes of bilateral optic disc edema. Of the 26 of 153 (17%) patients with known IIH (Group 3), 5 had papilledema and 4 required urgent intervention. The most common diagnosis was IIH (58/79). Compared with IIH, patients with secondary causes of intracranial hypertension were older (P = 0.002), men (P < 0.001), not obese (P < 0.001), and more likely to have neurologic symptoms (P = 0.002).

Conclusions:
Inpatient and ED consultations for “papilledema” are increasing. Of the 153 ED and inpatient neuro-ophthalmology consultations seen for “papilledema” over 1 year, one-third of patients with optic disc edema of unknown cause before presentation to our ED had new vision- or life-threatening disease, supporting the need for prompt identification and evaluation of optic disc edema in the ED. In the face of limited access to neuro-ophthalmologists, this study supports the need for emergency department access to expert eye-care evaluation or ocular fundus camera for prompt identification of optic disc edema and standardized evaluation for neurologic emergencies.
Interdependence of trabecular microarchitectural parameters from micro-computed tomography
Authors: Neeteson Nathan J. , Bugbird Annabel R. , Burt Lauren A. , Boyd Steven K. 
Published: March 2024

ABSTRACTStandard microarchitectural analysis of bone using micro-computed tomography produces a large number of parameters that quantify the structure of the trabecular network. Analyses that perform statistical tests on many parameters are at elevated risk of making Type I errors. However, when multiple testing correction procedures are applied, the risk of Type II errors is elevated if the parameters being tested are strongly correlated. In this article, we argue that four commonly used trabecular microarchitectural parameters (thickness, separation, number, and bone volume fraction) are interdependent and describe only two independent properties of the trabecular network. We first derive theoretical relationships between the parameters based on their geometric definitions. Then, we analyze these relationships with an aggregatedin vivodataset with 2987 images from 1434 participants and a synthetically generated dataset with 144 images using principal component analysis (PCA) and linear regression analysis. With PCA, when trabecular thickness, separation, number, and bone volume fraction are combined, we find that 92% to 97% of the total variance in the data is explained by the first two principal components. With linear regressions, we find high coefficients of determination (0.827 – 0.994) and fitted coefficients within expected ranges. These findings suggest that to maximize statistical power in future studies, only two of trabecular thickness, separation, number and bone volume fraction should be used for statistical testing.
Exploring the Relationship Between Smoking and Poor Sleep Quality: A Cross-Sectional Study Using NHANES
Authors: Sun Haoxiong 
Published: March 2024

AbstractIntroductionAlthough some previous research has reported the relationship between smoking and sleep disorders, there is a lack of studies with large sample sizes and determining the potential dose-response relationship.MethodsThis study used data from 30,269 participants from the NHANES database (2007-2020). Logistic regression models were used to assess the associations between smoking and sleep outcomes, including insufficient sleep duration, sleep problems, snoring, and snorting or stop breathing during sleep. Dose-response relationships were explored using restricted cubic splines.ResultsLight-to-moderate and heavy smokers had significantly higher odds of experiencing sleep disorders compared to non-smokers. The odds ratios for Light-to-moderate and heavy smokers are 1.341 and 2.101 for insufficient sleep duration, 1.493 and 2.142 for sleep problems, 1.444 and 2.003 for snoring, and 1.439 and 1.720 for snorting or stop breathing during sleep, respectively. Dose-response analyses revealed that the odds of these sleep outcomes increased with higher smoking frequency.ConclusionSmoking can lead to increased odds of sleep disorders, and the more an individual smokes, the higher the odds of experiencing sleep disorders.
ΔNp63-restricted viral mimicry response impedes cancer cell viability and remodels tumor microenvironment in esophageal squamous cell carcinoma
Authors: Yu Valen Zhuoyou , So Shan Shan , Lung Bryan Chee-chad , Hou George Zhaozheng , Wong Carissa Wing-yan , Chow Larry Ka-yue , Chung Michael King-yung , Wong Ian Yu-hong , Wong Claudia Lai-yin , Chan Desmond Kwan-kit , Chan Fion Siu-yin , Law Betty Tsz-ting , Xu Kaiyan , Tan Zack Zhen , Lam Ka-on , Lo Anthony Wing-ip , Lam Alfred King-yin , Kwong Dora Lai-wan , Ko Josephine Mun-yee , Dai Wei , Law Simon , Lung Maria Li 
Published: March 2024

AbstractTumor protein p63 isoform ΔNp63 plays roles in the squamous epithelium and squamous cell carcinomas (SCCs), including esophageal SCC (ESCC). By integrating data from cell lines and our latest patient-derived organoid cultures, derived xenograft models, and clinical sample transcriptomic analyses, we identified a novel and robust oncogenic role of ΔNp63 in ESCC. We showed that ΔNp63 maintains the repression of cancer cell endogenous retrotransposon expression and cellular double-stranded RNA sensing. These subsequently lead to a restricted cancer cell viral mimicry response and suppressed induction of tumor-suppressive type I interferon (IFN-I) signaling through the regulations of Signal transducer and activator of transcription 1, Interferon regulatory factor 1, and cGAS-STING pathway. The cancer cell ΔNp63-IFN-I signaling axis affects both the cancer cell and tumor-infiltrating immune cell (TIIC) compartments. In cancer cells, depletion of ΔNp63 resulted in reduced cell viability. ΔNp63 expression is negatively associated with the anticancer responses to viral mimicry booster treatments targeting cancer cells. In the tumor microenvironment, cancer cellTP63expression negatively correlates with multiple TIIC signatures in ESCC clinical samples. ΔNp63 depletion leads to increased cancer cell antigen presentation molecule expression and enhanced recruitment and reprogramming of tumor-infiltrating myeloid cells. Similar IFN-I signaling and TIIC signature association with ΔNp63 were also observed in lung SCC. These results support the potential application of ΔNp63 as a therapeutic target and a biomarker to guide candidate anticancer treatments exploring viral mimicry responses.
A widespread family of ribosomal peptide metallophores involved in bacterial adaptation to metal stress
Authors: Leprevost Laura , Jünger Sophie , Lippens Guy , Guillaume Céline , Sicoli Giuseppe , Oliveira Lydie , Rivera-Millot Alex , Billon Gabriel , Henry Céline , Antoine Rudy , Zirah Séverine , Dubiley Svetlana , Li Yanyan , Jacob-Dubuisson Françoise 
Published: March 2024

AbstractRibosomally synthesized and post-translationally modified peptides (RiPPs) are a structurally diverse group of natural products that bacteria employ in their survival strategies. Herein, we characterized the structure, the biosynthetic pathway and the mode of action of a new RiPP family called bufferins. With thousands of homologous biosynthetic gene clusters throughout the eubacterial phylogenetic tree, bufferins form by far the largest family of RiPPs modified by multinuclear non-heme iron-dependent oxidases (MNIO, DUF692 family). UsingCaulobacter vibrioidesbufferins as a model, we showed that the conserved Cys residues of their precursors are transformed into 5-thiooxazoles, further expanding the reaction range of MNIO enzymes. This rare modification is installed in conjunction with a partner protein of the DUF2063 family. Bufferin precursors are the first examples of bacterial RiPPs found to feature an N-terminal Sec signal peptide and thus to be exported by the ubiquitous Sec pathway, a new paradigm in the RiPP field. Other original features of bufferins are their large size and protein-like fold, which blurs the line between modified peptides and proteins. We reveal that bufferins are involved in copper homeostasis, and their metal-binding propensity requires the thiooxazole heterocycles. Bufferins enhance bacterial growth under copper stress by sequestering excess metal ions in the periplasm. Our study thus describes a large family of RiPP metallophores and unveils a widespread but overlooked metal homeostasis mechanism in eubacteria likely to be relevant to One-Health strategies.Significance statementCopper is both essential and toxic in excess. Bacteria face copper in their environments, notably in phagocytes, hence they have developed several defense mechanisms. We discovered a widespread strategy of protection from copper, through the biosynthesis of natural products that we call bufferins. Bufferins areribosomally synthesizedpost-translationally modifiedpeptides (RiPPs), natural products with key roles in bacterial physiology and ecology. Bufferins enhance bacterial growth under copper stress by complexing with the metal using thiooxazole heterocycles that result from enzymatic modification of cysteine residues. With thousands of homologs throughout the eubacterial phylogenetic tree, bufferins represent a highly prevalent strategy of adaptation to metal stress. They are larger in size than most RiPPs, expanding the concept of RiPPs to modified proteins.
Leptonic ALP portal to the dark sector
Authors: Armando Giovanni , Panci Paolo , Weiss Joachim , Ziegler Robert 
Published: March 2024

We discuss the leptonic axionlike particle (ALP) portal as a simple scenario that connects observed discrepancies in anomalous magnetic moments to the dark matter relic abundance. In this framework an axionlike particle in the multi-MeV range couples to SM leptons and a dark matter (DM) fermion, with mass above the ALP mass but below 1 GeV. The ALP contributes to (g−2)μ and (g−2)e dominantly through two-loop Barr-Zee diagrams, while the DM abundance is generated by p-wave annihilation to ALP pairs. Constraints from beam-dump experiments, colliders, and cosmic microwave background probes are very stringent, and restrict the viable parameter space to a rather narrow region that will be tested in the near future.

Published by the American Physical Society
2024
Effect of hot air inclined jet impingement to container for controlling of energy storage of PCM: experimental and numerical investigation
Authors: Oztop Hakan F. , Kiyak Burak , Aksoy Ishak Gökhan 
Published: March 2024

Purpose
This study aims to focus on understanding how different jet angles and Reynolds numbers influence the phase change materials’ (PCMs) melting process and their capacity to store energy. This approach is intended to offer novel insights into enhancing thermal energy storage systems, particularly for applications where heat transfer efficiency and energy storage are critical.

Design/methodology/approach
The research involved an experimental and numerical analysis of PCM with a melting temperature range of 22 °C–26°C under various conditions. Three different jet angles (45°, 90° and 135°) and two container angles (45° and 90°) were tested. Additionally, two different Reynolds numbers (2,235 and 4,470) were used to explore the effects of jet outlet velocities on PCM melting behaviour. The study used a circular container and analysed the melting process using the hot air inclined jet impingement (HAIJI) method.

Findings
The obtained results showed that the average temperature for the last time step at Ф = 90° and Re = 4,470 is 6.26% higher for Ф = 135° and 14.23% higher for Ф = 90° compared with the 45° jet angle. It is also observed that the jet angle, especially for Ф = 90°, is a much more important factor in energy storage than the Reynolds number. In other words, the jet angle can be used as a passive control parameter for energy storage.

Originality/value
This study offers a novel perspective on the effective storage of waste heat transferred with air, such as exhaust gases. It provides valuable insights into the role of jet inclination angles and Reynolds numbers in optimizing the melting and energy storage performance of PCMs, which can be crucial for enhancing the efficiency of thermal energy storage systems.
Bearing the brunt: a daily diary examination of abusive supervision and the sustaining role of coworkers’ support
Authors: Akram Zubair , Ahmad Saima , Akram Umair , Khan Abdul Gaffar , Huo Baofeng 
Published: March 2024

Purpose
This study aims to examine the relationship between abusive supervision and workplace incivility using a dual theoretical framework. First, it draws on the ego depletion theory to investigate the relationship between abusive supervision and incivility by exploring the mediating role of ego depletion. Second, it integrates the job demands–resources model with the ego depletion theory to examine how perceived co-workers’ support functions as a buffer in mitigating the effects of ego depletion on incivility.

Design/methodology/approach
The authors tested our moderated mediation model using hierarchical linear modeling through an experience-sampling study based on data collected from a participants across five consecutive workdays.

Findings
The findings reveal employees subjected to abusive supervision are more likely to experience a depletion of self-regulatory resources. Moreover, the authors found a positive association between ego depletion and workplace incivility, suggesting that diminished self-control resulting from abusive supervision contributes to a higher likelihood of engaging in uncivil workplace behaviors. In addition, perceived coworkers’ support emerged as a significant moderating factor that attenuates the indirect impact of abusive supervision on workplace incivility through ego depletion. Specifically, when perceived coworkers’ support is high, the negative influence of abusive supervision on ego depletion, and subsequently, on workplace incivility, is mitigated.

Originality/value
By exploring ego depletion as the underlying mechanism and boundary conditions imposed by perceived coworker support on the relationship between abusive supervision and workplace incivility, this research contributes to a nuanced understanding of the intricate dynamics of this relationship. Based on the research findings, the authors advocate that organizations should establish and integrate support services, such as counseling and employee assistance programs, to reduce the emotional turmoil caused by abusive supervision.