bluuebunny/crossref_metadata_2025_split huggingface dataset:
Institutional and Regional Variation in Opioid Prescribing for Hospitalized Infants in the US
Authors: Keane Olivia A. , Ourshalimian Shadassa , Lakshmanan Ashwini , Lee Henry C. , Hintz Susan R. , Nguyen Nam , Ing Madeleine C. , Gong Cynthia L. , Kaplan Cameron , Kelley-Quon Lorraine I. 
Published: March 2024

ImportanceHigh-risk infants, defined as newborns with substantial neonatal-perinatal morbidities, often undergo multiple procedures and require prolonged intubation, resulting in extended opioid exposure that is associated with poor outcomes. Understanding variation in opioid prescribing can inform quality improvement and best-practice initiatives.ObjectiveTo examine regional and institutional variation in opioid prescribing, including short- and long-acting agents, in high-risk hospitalized infants.Design, Setting, and ParticipantsThis retrospective cohort study assessed high-risk infants younger than 1 year from January 1, 2016, to December 31, 2022, at 47 children’s hospitals participating in the Pediatric Health Information System (PHIS). The cohort was stratified by US Census region (Northeast, South, Midwest, and West). Variation in cumulative days of opioid exposure and methadone treatment was examined among institutions using a hierarchical generalized linear model. High-risk infants were identified by International Statistical Classification of Diseases and Related Health Problems, Tenth Revision codes for congenital heart disease surgery, medical and surgical necrotizing enterocolitis, extremely low birth weight, very low birth weight, hypoxemic ischemic encephalopathy, extracorporeal membrane oxygenation, and other abdominal surgery. Infants with neonatal opioid withdrawal syndrome, in utero substance exposure, or malignant tumors were excluded.ExposureAny opioid exposure and methadone treatment.Main Outcomes and MeasuresRegional and institutional variations in opioid exposure.ResultsOverall, 132 658 high-risk infants were identified (median [IQR] gestational age, 34 [28-38] weeks; 54.5% male). Prematurity occurred in 30.3%, and 55.3% underwent surgery. During hospitalization, 76.5% of high-risk infants were exposed to opioids and 7.9% received methadone. Median (IQR) length of any opioid exposure was 5 (2-12) cumulative days, and median (IQR) length of methadone treatment was 19 (7-46) cumulative days. There was significant hospital-level variation in opioid and methadone exposure and cumulative days of exposure within each US region. The computed intraclass correlation coefficient estimated that 16% of the variability in overall opioid prescribing and 20% of the variability in methadone treatment was attributed to the individual hospital.Conclusions and RelevanceIn this retrospective cohort study of high-risk hospitalized infants, institution-level variation in overall opioid exposure and methadone treatment persisted across the US. These findings highlight the need for standardization of opioid prescribing in this vulnerable population.
The effect of aggressive fantasizing on aggressive inclinations: Moderating effects of dispositional anger expression
Authors: Twardawski Mathias , Angerl Eva‐Maria , Lobbestael Jill 
Published: March 2024

AbstractExperiencing victimization or mistreatment often induces feelings of anger. The catharsis hypothesis suggests that venting anger may aid in alleviating these negative emotions. Although this hypothesis has faced criticism, therapeutic interventions rooted in catharsis are employed to assist victims in managing their anger. One notable application of the catharsis principle in psychotherapeutic practice with victims involves engaging in aggressive fantasies: Victims who harbor aggressive fantasies against their offenders are supported in working with these fantasies to navigate the complex emotions arising from their victimization. Research investigating the effects of aggressive fantasizing on victims has yielded inconsistent findings, with some studies indicating positive and others suggesting negative outcomes. Herein, we examine whether (instructed) aggressive fantasizing diminishes (catharsis hypothesis) or heightens (escalation hypothesis) subsequent aggressive inclinations compared to non‐aggressive fantasizing. Additionally, the moderating role of victims' dispositional tendencies to express anger, specifically Anger Expression‐out and Anger Expression‐control, in the relationship between aggressive fantasizing and aggressive inclinations was examined. We recruited individuals (N = 245) who had experienced victimization through highly unfair treatment and instructed them to imagine confronting their wrongdoer using either aggressive or non‐aggressive communication. Participants then reported their aggressive inclinations. Data supported the escalation hypothesis, revealing that aggressive fantasizing amplifies subsequent aggressive inclinations. Importantly, individuals with higher Anger Expression‐out demonstrated greater susceptibility to this effect; whereas, Anger Expression‐control did not moderate the link between aggressive fantasizing and inclinations. These findings further challenge the catharsis hypothesis and underscore the role of dispositional anger expression tendencies on the effects of aggressive fantasizing.
No gadolinium K‐edge detected on the first clinical photon‐counting computed tomography scanner
Authors: Baubeta Erik , Laurin Gadsböll Eva , Will Leon , Holmquist Fredrik , Aurumskjöld Marie‐Louise 
Published: March 2024

AbstractPurposeThis study aimed to elucidate whether gadolinium contrast in clinically relevant doses can be used with photon‐counting computed tomography (PCCT) as an alternative contrast agent in clinical applications.Material/methodsA CTDI phantom with 3D printed rods filled with different concentrations of gadolinium and iodine contrast was scanned in a PCCT and an energy‐integrated computed tomography (EICT). Attenuation values at different monoenergetic steps were extracted for each contrast concentration.ResultsFor PCCT, gadolinium reached an attenuation >100 HU (103 HU) at 40 keV with a concentration 5 mmol/L whereas the same level was reached at 50 keV (118 HU) for 10 mmol/L and 90 keV (114 HU) for 25 mmol/L. For iodine, the same level of attenuation was reached at 100 keV (106 HU) with a concentration 8.75 mg I/mL.For EICT the lowest gadolinium contrast concentration needed to reach >100 HU (108 HU) was 10 mmol/L at 50 keV. For 25 mmol/L 100 HU was reached at 100 keV. For iodine contrast 108 HU was reached at 110 keV for 8.75 mg I/mL.ConclusionNo K‐edge potential or difference in attenuation curves between iodine and gadolinium contrast is detected on the first clinical available PCCT. Clinically relevant attenuation levels were barely achieved in this setting with gadolinium concentrations approved for human use. The results of this study suggest that, given current scanning technology, gadolinium is not a clinically useful contrast agent for computed tomography because no K‐edge was detected.
Short term power load forecasting system based on improved neural network deep learning model
Authors: Yuan Lulu 
Published: March 2024

AbstractThe electricity load prediction is closely related to production and daily life. The electricity load prediction is also a very important task. With the widespread application of smart grids, load data shows an exponential growth trend. The huge amount of data in the load makes power prediction even more difficult. On the basis of traditional prediction algorithms, a power load prediction model based on machine learning and neural networks is designed. Because the single model prediction has the unstable results, a combined model is obtained based on the ensemble learning idea and two single model prediction method. The prediction results are detected by the load data. From the experimental results, the mean absolute percentage error (MAPE) of the AdaBoost‐GRU data fusion model is 0.066%. Compared to the AdaBoost‐GRU data fusion model, the MAPE decreases by 1.59% and 1.12%, respectively. The relative mass scores of the two groups decrease by 132.57% and 89.14%, respectively. The prediction accuracy is improved, which has advantages compared to traditional combination models. It can effectively enhance the accuracy of short‐term power grid load forecasting. It is an important scientific and practical reference for power grid decision‐making.
Weakly Polar Ether‐Aided Ionic Liquid Electrolyte Enables High‐Performance Sodium Metal Batteries over Wide Temperature Range
Authors: Liu Yang , Lu Suwan , Wang Zhicheng , Xu Jingjing , Weng Shixiao , Xue Jiangyan , Tu Haifeng , Zhang Fengrui , Liu Lingwang , Gao Yiwen , Li Hong , Zheng Jieyun , Wu Xiaodong 
Published: March 2024

AbstractSodium (Na) metal batteries (SMBs) have attracted many attentions because of high specific capacity and low redox potential. However, SMBs encounter several crucial challenges including Na dendrites growth, severe interfacial side reactions and safe issues from liquid organic electrolyte. In this study, a non‐flammable 1,2‐bis (1,1,2,2‐tetrafluoroethoxy) ethane (TFEE) aided ionic liquid (IL) electrolyte (TILE) is reported with sodium bis(trifluoromethylsulfonyl)imide (NaTFSI) salt and N‐methyl‐N‐propylpyrrolidinium bis(fluorosulfonyl)imide ([Py13][FSI]) IL solvent. The IL solvent contains plentiful organic cations and anions, which helps to provide a cationic shielding effect by [Py13]+ cations and regulate the Na+ solvation structure with more FSI− and TFSI− anions. The unique solvation structure of Na+ facilitates a stable inorganic‐rich solid electrolyte interphase (SEI), effectively inhibiting unstable Na deposition and suppressing side reactions between the electrolyte and Na‐metal in SMBs. Therefore, the Na3V2(PO4)3 (NVP)||Na cells with TILE can deliver good rate capability and superior cycling performance with capacity retention of 95.5% and Coulombic efficiency of ≈99.9% after 2000 cycles at 5C rate and 25 °C. The high‐voltage NaNi0.33Fe0.33Mn0.33O2(NFM)||Na cells with TILE can also deliver good cycling performance with capacity retention of 92% after 150 cycles in the voltage range of 2.0–4.1 V at 0.5C rate and 25 °C.
Efficient Circularly Polarized Luminescence and Bright White Emission from Hybrid Indium‐Based Perovskites via Achiral Building Blocks
Authors: Du Liping , Zhou Qiwei , He Qingqing , Liu Yan , Shen Yueqi , Lv Huijun , Sheng Lingling , Cheng Tao , Yang Hao , Wan Li , Fang Yuan , Ning Weihua 
Published: March 2024

AbstractChiral organic‐inorganic hybrid perovskites (OIHPs) exhibit exceptional optical and chiral properties, demonstrating potential for 3D display, circularly polarized light‐emitting diodes (CP‐LEDs), and CPL switches. However, the construction of chiral OIHPs often relies on chiral building blocks, limiting chemical diversity, and possessing challenges in achieving large asymmetry factor (glum) without sacrificing photoluminescence quantum yield (PLQY). Here, Chiral DMA4In1‐xSbxCl7 (DMA = dimethylammonium, x = 0 to 1) with superior circularly polarized luminescence (CPL) are successfully constructed based on achiral building blocks DMA+ and metal halides. By optimizing the Sb3+ content, bright white emission with a high PLQY of 69.13% is achieved, as well as near‐unity PLQY yellow emission and strong CPL signals with a glum of up to +1.40 × 10−2, exhibiting a performance comparable to state‐of‐the‐art chiral OIHPs. Combining optical characterizations and theoretical calculations reveal that these intriguing properties originate from the intrinsic chiral helical structures and a pair of perfect complementary color emissions in DMA4In1‐xSbxCl7. In addition, DMA4In1‐xSbxCl7 exhibit excellent thermal stability and mild thermal quenching in the temperature range of 300 to 420 K. These fascinating properties suggest that DMA4In1‐xSbxCl7 have significant applications in white light‐emitting diodes (WLED), 3D displays and anti‐counterfeiting.
High‐Temperature Wettable Water‐Based Lubricants toward Hot Rolling Lubrication
Authors: Hai Ao , Li Shisen , He Jiaqi , He Shaofan , Dai Haoyu , Liu Xubo , Sun Jianlin , Dong Zhichao , Jiang Lei 
Published: March 2024

AbstractWater‐based lubricants have attractive properties compared to flammable oily lubricants but in high‐temperature environments remain a tricky challenge due to the Leidenfrost effect‐induced poor wettability once contacting sufficiently hot surfaces. Herein, a surfactant‐modified Laponite nanoclay (LNC), as a prototype water‐based lubricant with considerable lubricity, exhibits spontaneous high‐temperature wettability by which the Leidenfrost point (LFP) can be improved above ≈350 °C on crude stainless steels, increasing by ≈140°C compared to pure water. The inter‐particle attractions between LNC nanoplates increase the liquid viscosity, causing viscous force of bulk water near the substrate, allowing in situ deposition of LNC layers on the hot surface to trigger three‐phase contact line (TCL) pinning. As a basis, wettable lubricants are further optimized on their lubricity by intercalating zwitterionic surfactants between LNC nanoplates, thereby reducing friction coefficient to ≈0.1. The LNC lubricants have been demonstrated in a four‐ball tribometer to simulate hot rolling lubrication, providing insights for high‐temperature metal processing, and potential applications in mechanical engineering and the aerospace field.
Tailored Cation–Anion Coordination in Carbonate Electrolyte Enabling a Rigid‐Flexible Compact Solid‐Electrolyte Interphase for Potassium Batteries
Authors: Ni Ling , Zhang Shu , Li Chuanchuan , Lu Jie , Li Junfeng , Wang Jinzhi , Zhang Shenghang , Chen Guansheng , Zhang Zengqi , Sun Fu , Xu Gaojie , Cui Zili , Cui Guanglei 
Published: March 2024

AbstractPotassium batteries have received extensive attention as a promising grid‐level storage technology. However, the anodes in potassium batteries using conventional carbonate‐based electrolyte systems always suffer from severe capacity deterioration, due to the heterogeneous and highly swollen solid‐electrolyte interphase (SEI) layer. Herein, a rigid‐flexible compact SEI consisting of rigid inner KF layer and flexible crosslinked oligomeric K–B(OCH2CH2)n (modified KEO), is designed by tailoring cation–anion coordination in 1 m carbonate electrolyte based on the main salt—potassium perfluorinated pinacolatoborate, (KB(O2C2(CF3)4)2, abbreviated as KPFB). Specifically, the KPFB tunes K+−anions coordinated configuration in K+ solvation sheaths by unique spatial structure and strong electron‐withdrawing effect of its eight −CF3 groups. With the assistance of rigid‐flexible compact SEI layer, the potassium metal symmetric cells stably cycle for more than 1600 hours in the conventional carbonate electrolyte (1 m KPFB‐EC/DEC). Moreover, K||graphite and K||Prussian blue (PB) batteries adopting this conventional carbonate electrolyte can operate for more than 500 and 120 cycles with high average Coulombic efficiency of 99.7% and 99.4%, respectively. The work provides new insights in customizing salt anion structure to reinforce SEI layer for high‐performance potassium batteries.
Multi‐Scale Design of Metal–Organic Framework Metamaterials for Broad‐Band Microwave Absorption
Authors: Qu Ning , Xu Guoxuan , Liu Yekun , He Mukun , Xing Ruizhe , Gu Junwei , Kong Jie 
Published: March 2024

AbstractThe development of nanocomposite microwave absorbers is a critical strategy for tackling electromagnetic pollution. However, challenges persist regarding material stability and achieving broadband absorption. Herein, a novel multi−scale design approach for metamaterial absorbers is proposed. First, a series of bimetallic (cobalt and copper) semiconductive metal–organic framework (SC−MOF) crystals with atomically resolved structures are successfully prepared to serve as building blocks for metamaterials. By simply adjusting the concentration ratio of the two ions, the controllable preparation of crystal morphology can be achieved. This enables to precisely tune the absorption peak and bandwidth range of the SC−MOF, resulting in excellent EMW absorption performance (effective absorption bandwidth: 6.16 GHz, minimum reflection loss: −61 dB). Based on this, printable inks are further constructed by encapsulating the SC−MOF in polydimethylsiloxane and 3D‐printed multi−layered metamaterial absorbers based on woodpile porous architecture. The metamaterial absorber demonstrates a near‐perfect absorption in the microwave spectrum (with a bandwidth of 11.33 GHz), closely matching theoretical simulations. This multi−scale design approach, combining precise MOF materials construction with topological structure design, offers new insights for the development of broadband microwave absorbers.
A Self‐Assembled 3D Model Demonstrates How Stiffness Educates Tumor Cell Phenotypes and Therapy Resistance in Pancreatic Cancer
Authors: Liu Ying , Okesola Babatunde O. , Osuna de la Peña David , Li Weiqi , Lin Meng‐Lay , Trabulo Sara , Tatari Marianthi , Lawlor Rita T. , Scarpa Aldo , Wang Wen , Knight Martin , Loessner Daniela , Heeschen Christopher , Mata Alvaro , Pearce Oliver M. T. 
Published: March 2024

AbstractPancreatic ductal adenocarcinoma (PDAC) is characterized by a dense and stiff extracellular matrix (ECM) associated with tumor progression and therapy resistance. To further the understanding of how stiffening of the tumor microenvironment (TME) contributes to aggressiveness, a three‐dimensional (3D) self‐assembling hydrogel disease model is developed based on peptide amphiphiles (PAs, PA‐E3Y) designed to tailor stiffness. The model displays nanofibrous architectures reminiscent of native TME and enables the study of the invasive behavior of PDAC cells. Enhanced tuneability of stiffness is demonstrated by interacting thermally annealed aqueous solutions of PA‐E3Y (PA‐E3Yh) with divalent cations to create hydrogels with mechanical properties and ultrastructure similar to native tumor ECM. It is shown that stiffening of PA‐E3Yh hydrogels to levels found in PDAC induces ECM deposition, promotes epithelial‐to‐mesenchymal transition (EMT), enriches CD133+/CXCR4+ cancer stem cells (CSCs), and subsequently enhances drug resistance. The findings reveal how a stiff 3D environment renders PDAC cells more aggressive and therefore more faithfully recapitulates in vivo tumors.
Micro‐Engineered Heart Tissues On‐Chip with Heterotypic Cell Composition Display Self‐Organization and Improved Cardiac Function
Authors: Cofiño‐Fabres Carla , Boonen Tom , Rivera‐Arbeláez José M. , Rijpkema Minke , Blauw Lisanne , Rensen Patrick C. N. , Schwach Verena , Ribeiro Marcelo C. , Passier Robert 
Published: March 2024

AbstractAdvanced in vitro models that recapitulate the structural organization and function of the human heart are highly needed for accurate disease modeling, more predictable drug screening, and safety pharmacology. Conventional 3D Engineered Heart Tissues (EHTs) lack heterotypic cell complexity and culture under flow, whereas microfluidic Heart‐on‐Chip (HoC) models in general lack the 3D configuration and accurate contractile readouts. In this study, an innovative and user‐friendly HoC model is developed to overcome these limitations, by culturing human pluripotent stem cell (hPSC)‐derived cardiomyocytes (CMs), endothelial (ECs)‐ and smooth muscle cells (SMCs), together with human cardiac fibroblasts (FBs), underflow, leading to self‐organized miniaturized micro‐EHTs (µEHTs) with a CM‐EC interface reminiscent of the physiological capillary lining. µEHTs cultured under flow display enhanced contractile performance and conduction velocity. In addition, the presence of the EC layer altered drug responses in µEHT contraction. This observation suggests a potential barrier‐like function of ECs, which may affect the availability of drugs to the CMs. These cardiac models with increased physiological complexity, will pave the way to screen for therapeutic targets and predict drug efficacy.
Structural Design for EMI Shielding: From Underlying Mechanisms to Common Pitfalls
Authors: Isari Ali Akbar , Ghaffarkhah Ahmadreza , Hashemi Seyyed Alireza , Wuttke Stefan , Arjmand Mohammad 
Published: March 2024

AbstractModern human civilization deeply relies on the rapid advancement of cutting‐edge electronic systems that have revolutionized communication, education, aviation, and entertainment. However, the electromagnetic interference (EMI) generated by digital systems poses a significant threat to the society, potentially leading to a future crisis. While numerous efforts are made to develop nanotechnological shielding systems to mitigate the detrimental effects of EMI, there is limited focus on creating absorption‐dominant shielding solutions. Achieving absorption‐dominant EMI shields requires careful structural design engineering, starting from the smallest components and considering the most effective electromagnetic wave attenuating factors. This review offers a comprehensive overview of shielding structures, emphasizing the critical elements of absorption‐dominant shielding design, shielding mechanisms, limitations of both traditional and nanotechnological EMI shields, and common misconceptions about the foundational principles of EMI shielding science. This systematic review serves as a scientific guide for designing shielding structures that prioritize absorption, highlighting an often‐overlooked aspect of shielding science.
Visualizing Nanoscale Interlayer Magnetic Interactions and Unconventional Low‐Frequency Behaviors in Ferromagnetic Multishelled Structures
Authors: Chen Guanyu , Zhang Ruixuan , Yuan Mingyue , Xue Shuyan , Liu Yihao , Li Bangxin , Luo Kaicheng , Lai Yuxiang , Zhang Jincang , Lv Hualiang , Che Renchao 
Published: March 2024

AbstractPrecise manipulation of van der Waals forces within 2D atomic layers allows for exact control over electron–phonon coupling, leading to the exceptional quantum properties. However, applying this technique to diverse structures such as 3D materials is challenging. Therefore, investigating new hierarchical structures and different interlayer forces is crucial for overcoming these limitations and discovering novel physical properties. In this work, a multishelled ferromagnetic material with controllable shell numbers is developed. By strategically regulating the magnetic interactions between these shells, the magnetic properties of each shell are fine‐tuned. This approach reveals distinctive magnetic characteristics including regulated magnetic domain configurations and enhanced effective fields. The nanoscale magnetic interactions between the shells are observed and analyzed, which shed light on the modified magnetic properties of each shell, enhancing the understanding and control of ferromagnetic materials. The distinctive magnetic interaction significantly boosts electromagnetic absorption at low‐frequency frequencies used by fifth‐generation wireless devices, outperforming ferromagnetic materials without multilayer structures by several folds. The application of magnetic interactions in materials science reveals thrilling prospects for technological and electronic innovation.