bluuebunny/crossref_metadata_2025_split huggingface dataset:
Understanding Micro‐Level Budgeting Behavior: How Cognitive Biases Shape Politicians' Budget Preferences
Authors: Overmans Tom , Grimmelikhuijsen Stephan 
Published: February 2025

ABSTRACTDecades of research emphasized collective behaviors in public budgeting, yet individual budget preferences remain underexplored. This paper argues that both well‐known and lesser‐known cognitive biases distort politicians' budget judgment, resulting in biased preferences. To test this, we conducted five preregistered experiments examining the impact of five biases—anchoring, herding, mental accounting, availability bias, and loss aversion—on budget preferences. Using data from 1825 municipal budgeters in The Netherlands, we reveal significant effects of anchoring, adherence to irrelevant budget labels (mental accounting), and overspending on items that attract media attention (availability bias) or emphasize gains (loss aversion). We also find that presenting decision information through infographics holds potential for improving judgment and mitigating biases in preferences. These findings challenge the view that budgeting is purely political, highlighting the role of cognitive factors in suboptimal budget decisions. We emphasize the need for further research into biases and debiasing mechanisms to advance budget decision‐making.
Exploring the impact of acute SARS‐CoV‐2 infection on headache pattern in patients with migraine: A novel Bayesian analysis
Authors: Yeh Jiunn‐Tyng , Wang Yen‐Feng , Tzeng Yi‐Shiang , Chen Shih‐Pin , Pan Li‐Ling Hope , Wang Shuu‐Jiun 
Published: February 2025

AbstractObjectivesTo analyze headache and migraine dynamics around severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection.BackgroundHeadache is a common symptom of SARS‐CoV‐2 infection, which caused the coronavirus disease 2019 (COVID‐19) pandemic. However, the daily changes in headache patterns in patients with migraine during the infection are unclear.MethodsThis study is a post hoc and retrospective study of patients with migraine and documented COVID‐19 diagnoses and headache diaries from a large prospective migraine cohort that consecutively enrolls eligible patients. Patients’ characteristics, headache and migraine patterns, and vaccination data were retrieved. Change points in daily headache or migraine rates of this cohort were identified from 28 days before (day −28) to 28 days after (day 28) the infection. We calculated and compared the weekly headache and migraine days of individual patients during pre‐infection, infection, and post‐infection periods based on the change points. We further categorized patients into those with increased headache days and those without to investigate if vaccinations affected the headache patterns by comparing the pre‐ and post‐infection headache days.ResultsA total of 463 patients, 370 (79.9%) females, with an age (mean ± standard deviation) of 41.5 ± 11.9 years, were enrolled. A total of 26,391 diary days were analyzed. The change‐point algorithm identified changes in headache rates on day −4 (95% credible interval: −5.0, −1.2) and day 12 (95% credible interval: 7.6, 17.0). For migraine attacks, the change points were day −2 (95% credible interval: −4.9, −0.8) and day 11 (95% credible interval: 7.6, 17.2). After the grouping based on these change points, we found that the weekly headache days (mean ± standard error of the mean) increased from 1.5 ± 0.1 days during pre‐infection to 1.8 ± 0.1 days during acute infection and recovered to 1.6 ± 0.1 days after infection. The weekly migraine days increased from 1.0 ± 0.1 day to 1.3 ± 0.1 days during acute infection and recovered to 1.1 ± 0.1 days. Female patients and those older than 40 had more abrupt changes in headache and migraine patterns. There was no impact of vaccinations on the headache pattern regardless of the type or dose of the vaccinations or the intervals between the last vaccination and the COVID‐19 diagnosis.ConclusionWe demonstrated that the headache and migraine rates among individuals with migraine escalated during the early stage of SARS‐CoV‐2 infection and returned to baseline along with systemic viral clearance.
Impact of time‐of‐day atezolizumab plus bevacizumab combination therapy infusion for unresectable hepatocellular carcinoma: A retrospective multicenter study
Authors: Naganuma Atsushi , Kakizaki Satoru , Hatanaka Takeshi , Hiraoka Atsushi , Tada Toshifumi , Hirooka Masashi , Kariyama Kazuya , Tani Joji , Atsukawa Masanori , Takaguchi Koichi , Itobayashi Ei , Fukunishi Shinya , Tsuji Kunihiko , Ishikawa Toru , Tajiri Kazuto , Toyoda Hidenori , Koshiyama Yuichi , Ogawa Chikara , Nishikawa Hiroki , Nishimura Takashi , Kawata Kazuhito , Kosaka Hisashi , Matsui Kosuke , Yata Yutaka , Tanaka Hironori , Ohama Hideko , Kuroda Hidekatsu , Matono Tomomitsu , Aoki Tomoko , Ochi Hironori , Imai Michitaka , Nakamura Shinichiro , Kanayama Yuki , Tanaka Kazunari , Tada Fujimasa , Yoshida Osamu , Nouso Kazuhiro , Morishita Asahiro , Tsutsui Akemi , Nagano Takuya , Itokawa Norio , Okubo Tomomi , Arai Taeang , Enomoto Hirayuki , Kaibori Masaki , Hiasa Yoichi , Kudo Masatoshi , Kumada Takashi ,   the Real‐life Practice Experts for HCC (RELPEC) Study Group, and HCC 48 Group (hepatocellular carcinoma experts from 48 clinics in Japan)
Published: February 2025

AbstractAimThis study aimed to evaluate the impact of infusion timing of time‐of‐day on clinical outcomes in patients with unresectable hepatocellular carcinoma (HCC) treated with atezolizumab plus bevacizumab combination therapy.MethodsA retrospective analysis was conducted using data from 751 unresectable HCC patients treated with atezolizumab plus bevacizumab between September 2020 and April 2024. Patients were categorized into morning (AM; n = 351) and afternoon (PM; n = 400) groups based on infusion timing of time‐of‐day. Outcomes, including progression‐free survival (PFS), overall survival, objective response rate, and disease control rate, were assessed using Kaplan–Meier survival analysis and Cox regression analysis.ResultsThe PFS was significantly longer in the AM group (8.6 months, 95% CI 7.6–10.5) compared with the PM group (6.0 months, 95% CI 5.4–7.0; p = 0.006). In contrast, overall survival was similar between the groups (AM: 24.7 months vs. PM: 21.4 months; p = 0.99). Cox regression analysis revealed that morning infusion was an independent favorable predictor of PFS (HR 1.23, 95% CI 1.04–1.45). Additionally, the AM group demonstrated superior objective response rate and disease control rate compared with the PM group, suggesting better tumor control.ConclusionMorning infusion of atezolizumab plus bevacizumab is associated with improved PFS and response rates in unresectable HCC patients, highlighting the potential for optimizing treatment outcomes through circadian timing.
Exploring Strategies to Connect Foreign Language Education With People Skills: Nurturing Intercultural Understanding Through the Rich Cultural Tapestry of Japanese Anime
Authors: Fukuda Makiko 
Published: February 2025

ABSTRACTIn today's globalized world, the importance of intercultural understanding and interpersonal skills is increasingly emphasized. This study focuses on linking foreign language education with intercultural effectiveness and investigates the impact of using anime as a tool for cultural understanding and the development of intercultural competence. The course is an introductory Japanese culture course for non‐Japanese learners, designed to introduce Japanese culture and values while encouraging students to deepen their understanding of their own thoughts, values, and culture. The intercultural effectiveness scale conducted before and after the 16‐week anime course indicates significant changes in students' self‐awareness, world orientation, relationship development, and emotional resilience—four of the six dimensions of the intercultural effectiveness scale. The results suggest that anime is not just a form of entertainment but also a valuable educational resource that enhances students' intercultural competence.
Overconsumption: A Systematic Literature Review and Future Research Agenda
Authors: Kumar Satinder , Kathuria Garima , Malhotra Dipti 
Published: February 2025

ABSTRACTOverconsumption is becoming a critical problem worldwide and adversely affects individual consumers, environment and society at large; due to which researchers' interest in this concern has grown. However, despite this increased attention, there is still a lack of a thorough evaluation, which has led to the fragmentation of the body of knowledge regarding overconsumption. As a result, it is acknowledged that a comprehensive overview of research that presents the literature on overconsumption is desirable. The study aims to fulfill such needs by conducting a detailed review of the literature by analyzing 62 related articles published in 37 peer‐reviewed scientific publications. The study follows the guidelines outlined in the SPAR‐4‐SLR protocol and aims to identify the most cited and co‐cited articles, keywords and researchers in overconsumption study. Leveraging the frameworks of Theory, Context, Characteristics, and Methods alongside Antecedents‐Decisions‐Outcomes, this study delves into a detailed examination of overconsumption outcomes and their interconnectedness. Through this comprehensive review, study aims to provide an insightful understanding on the multifaceted impacts of overconsumption. The review also encompasses overconsumption antecedents to the extent that they are linked to the resulting outcomes. Additionally, we determined that the current literature lacks comprehensive theories and primarily focuses on food overconsumption, neglecting various other industries. Therefore, this review provides an outline of the current scientific knowledge of overconsumption and makes substantial contributions to the literature and its implications. Ultimately, this study identifies gaps in existing body of knowledge and offers a well‐organized roadmap for future research.
An Educational Intervention to Reduce Regulated Medical Waste: The Inpatient Medicine and Outpatient Dermatology Settings
Authors: Silva Genevieve S. , Gotschall Jeromy W. , Hu Fengling , Whidden Elizabeth , Cunningham Phoebe , Niculcea Jacob , Chapman Cody , Sharma Prateek V. , Evans Greg , Hussain Farah , Chiesa Fuxench Zelma C. , Knox Kirstin , Rosenbach Misha 
Published: February 2025

ABSTRACTBackgroundImproving regulated medical waste (RMW) management is crucial for enhancing planetary health and cost savings. We sought to assess an educational intervention on clinical staff understanding and behavior regarding RMW management.MethodsThis two‐month (2023–2024) controlled, prospective educational intervention at the University of Pennsylvania Health System surveyed healthcare workers, including physicians, nurses, and medical assistants, from four inpatient medicine floors and two dermatology clinics. Half of the medicine and dermatology settings were controls. The intervention included in‐person staff training sessions and printed materials (posters, bin stickers) describing waste segregation and RMW's environmental, health, and cost impacts. A deidentified online survey pre‐ and post‐intervention measured RMW knowledge and behaviors. The primary outcome was a change in performance on survey questions on proper RMW disposal and RMW's negative externalities. Secondary outcomes were self‐reported changes in environmental beliefs and waste stewardship motivators and behaviors, qualitative responses around stewardship barriers, and the impact of clinical role on intervention efficacy.ResultsAverage baseline inpatient knowledge scores were 6.17 of 9 versus 7.51 for outpatient. The inpatient intervention increased the odds of answering each question correctly by 3‐fold (odds ratio: 3.71, 95% CI: 2.218–6.401, p < 0.001). The outpatient clinical role was associated with receptivity to the intervention: the intervention effect was 12.7 times stronger for nursing staff than for physicians (95% CI: 1.86, 263.29, p = 0.024). The intervention improved the overall understanding of RMW's negative environmental impact.ConclusionsAn educational intervention can improve understanding of RMW's proper disposal and environmental impact, particularly among nursing staff, and inform future interventions.
Extended Typing of Common Erythrocyte Antigens in Tunisian Blood Donors and Its Usefulness in Transfusion Immunology
Authors: Sellami Mohamed Hichem , Ferchichi Hamida , Ghazouani Eya , Dellai Noura , Boughzala Yesmine , Aissa Wafa , Chaabane Manel , Kâabi Houda , Hmida Slama 
Published: February 2025

ABSTRACTExtended RBC antigens typing is very valuable in transfusion immunology since it is highly recommended to ensure better transfusion practices and avoid transfusion‐related complications and to establish registries for rare blood donors as recommended by the International Society of Blood Transfusion and World Health Organization.A group of 236 Tunisian blood donors were genotyped for 19 common blood loci using the Sequence‐specific primers polymerase chain reaction (SSP‐PCR) method. The statistical analysis was done using the HaploView Software.The study showed the dominance of the loci: RHCE*e, KEL*02, FY*02 and CO*01; and the absence of the homozygous state of the CO*02 allele. Furthermore, two complete linkage disequilibrium leading to the absence of the two alleles RHCE*C‐RHCE*E (C‐E) and FY*01N.01 (FY*Anull) were detected. Additionally, it appeared that approximately 91% of these blood donors are positive for the RHD gene; and all subjects who lacked the RHD exon 10 are homozygous for the RHCE*c and RHCE*e variants. The study also revealed that the RH1 negative blood cannot be universal to the Rh system because almost all RH1 negative donated blood is RH:‐2,4,‐3,5 (ccee), which may constitute a risk in some recipients carrying the anti‐RH4 and/or anti‐RH5 antibodies.Considering that some donated RBC units may contain blood with very immunogenic phenotypes, great caution is required when transfusing some subjects, especially in emergency situations because it can be a step towards subsequent complex or multiple alloimmunization.
Young People as Actors in Their Occupational Careers: Effective Strategies to Increase the Chances of Entering an Attractive VET Programme After Leaving a General Education School in Germany
Authors: Schuchart Claudia , Schimke Benjamin 
Published: February 2025

ABSTRACTThis article focuses on the question of what strategies general education graduates can use to improve their chances of entering an attractive vocational education and training (VET) programme in Germany. We look, in particular, at grades in the school‐leaving certificate and the additional acquisition of a higher qualification at a vocational school. By using a vignette study, we focus on the selection by companies that offer training. Our results show that excellent grades in the school‐leaving certificate of graduates with only an intermediate school‐leaving qualification or an entrance qualification for a university of applied sciences improve their chances of entering a VET programme in comparison to more highly qualified competitors with very poor grades. One far more effective way is to upgrade their qualification at a vocational school in combination with professional knowledge relevant to the field of the desired VET programme. In particular, this protects graduates with an intermediate school‐leaving qualification from a devaluation of their qualification when applying for a VET programme with a high proportion of applicants who have a university entrance qualification. However, there is a negative effect on their chances if they upgrade their qualification in a vocational field that is not relevant to the desired VET programme. This indicates the importance of career counselling at schools.
Influence of best objective response to first‐line treatment on survival outcomes in advanced urothelial carcinoma in the era of sequential therapy with enfortumab vedotin
Authors: Kobatake Kohei , Goto Keisuke , Sakamoto Yuki , Iwane Kyohsuke , Nishida Kensuke , Hashimoto Kunihiro , Asami Akihiro , Iwamoto Hideo , Hayashi Tetsutaro , Takemoto Kenshiro , Naito Miki , Miyamoto Shunsuke , Sekino Yohei , Kitano Hiroyuki , Goriki Akihiro , Hieda Keisuke , Hinata Nobuyuki 
Published: February 2025

ObjectiveThis study evaluated whether first‐line treatment affects survival outcomes in patients with advanced urothelial carcinoma undergoing sequential therapy with chemotherapy, immune checkpoint inhibitors, and enfortumab vedotin.MethodsThis multicenter retrospective study included 57 patients treated at Hiroshima University Hospital and its affiliated institutions between 2009 and 2024. Patients received chemotherapy as a first‐line treatment (gemcitabine plus cisplatin or carboplatin), followed by second‐line immune checkpoint inhibitors (pembrolizumab or avelumab) and third‐line enfortumab vedotin. Assessed outcomes included overall survival and time to treatment failure. Cox regression analysis identified prognostic factors for overall survival.ResultsOver a median follow‐up of 20.5 months, median overall survival was not reached after first‐line treatment. Gemcitabine with cisplatin was selected in 31.6% of cases, while gemcitabine and carboplatin was chosen in 68.4% of cases as the first‐line treatment; subsequently, 66.7% received pembrolizumab, and 33.3% received avelumab in the second‐line treatment. Patients who achieved a complete or partial response with the first‐line treatment had significantly longer overall survivals from both first‐line and enfortumab vedotin initiation than those with stable or progressive disease. In cases that achieved complete or partial responses, avelumab was more frequently selected as a second‐line therapy. However, in the first‐line treatment, multivariate analysis identified only stable or progressive disease as a significant predictor of worse overall survival.ConclusionThe best response to first‐line treatment predicted both overall survival from first‐line initiation and outcomes following enfortumab vedotin treatment, underscoring its prognostic value in sequential therapy for patients with advanced urothelial carcinoma.
The molecular mechanisms of defensive‐grade organic acid biosynthesis in ground beetles
Authors: Rork Adam M. , Xu Sihang , Attygalle Athula , Renner Tanya 
Published: February 2025

AbstractInsects are known to synthesise and secrete hundreds of unique defensive chemicals, including caustic acids, pungent phenolics and citrusy terpenes. Despite efforts to characterise the defensive chemistry of ground beetles (Coleoptera: Carabidae), our knowledge of semiochemical evolution within the family and how these compounds are biosynthesised remains limited. Few studies have demonstrated the likely biosynthetic precursors of select compounds in certain taxa and only one has demonstrated which genes may be involved in the biosynthesis of formic acid. Here, we characterise the defensive chemistry and generate defensive gland transcriptomes for ground beetle species representing two defensive chemical classes: the formic acid producer Platynus angustatus and the methacrylic acid producer Pterostichus moestus. Through comparative transcriptome analyses, we demonstrate that co‐option of distinct primary metabolic pathways may be involved in formic acid and methacrylic acid biosynthesis in the defensive glands of these taxa. These results expand our knowledge of ground beetle defensive chemistry and provide additional evidence that co‐option of existing primary metabolic pathways plays a major role in the evolution of ground beetle chemical defence.
A potential route for ZnSiN2 formation from zinc cyanamide and SiO2‐based precursor via the facile, low‐temperature process
Authors: Zushi Ren , Hayashi Yamato , Takizawa Hirotsugu 
Published: February 2025

AbstractII–IV‐N2‐type compounds (II = Mg, Mn, Zn, etc., IV = Si, Ge, Sn, etc.) are promising semiconductor materials which are composed of earth‐abundant elements. However, given their low thermal decomposition temperatures, the synthesis of II–IV‐N2‐type nitrides necessitates high temperature and pressure or vacuum, requiring high energy consumption and complicated processes. In this study, focusing on ZnSiN2, a simple and energy‐efficient synthesis using zinc cyanamide and oxide precursor powders was developed. SiO2‐based precursors with a Zn constituent were synthesized by a liquid‐phase method using ultrasound, and wurtzite‐type ZnSiN2 and SiO2 composite was successfully synthesized by heating the precursor at 1000°C with urea under nitrogen atmosphere. Mechanistically, zinc cyanamide, a reaction intermediate, contributed to the formation of ZnSiN2 phase. Thus, a mixed powder of separately synthesized zinc cyanamide and precursors powder was heated at 900°C under nitrogen atmosphere, affording the homogeneous wurtzite‐type ZnSiN2 phase. This new process enables the facile synthesis of ZnSiN2 at low temperatures and ambient pressures from stable precursor system.
Strength enhancement strategies in brazing Ti alloys to non‐oxide ceramics: An overview of Ti–6Al–4V/Si3N4 joints
Authors: Ong Fei Shen , Tobe Hirobumi , Sato Eiichi 
Published: February 2025

AbstractThe growing demand for lightweight, heat‐resistant aerospace structures with intricate geometries has driven the integration of non‐oxide ceramics and Ti alloys, addressing the inherent workability and scalability challenges associated with ceramics when used independently. Brazing with eutectic Ag–Cu‐based fillers has emerged as a pivotal technique for fabricating reliable joints between these dissimilar materials. This paper provides a focused overview of strategies to enhance the mechanical reliability of brazed joints between Ti alloys and non‐oxide ceramics, focusing on Ti–6Al–4V (mass%) and Si3N4. Key challenges influencing joint strength are discussed, including tensile residual stresses from mismatched coefficients of thermal expansion, the limited plastic deformability of Ti‐alloy substrates, and the formation of hard Ti‐based intermetallic compounds. Recent advancements to overcome these challenges are highlighted, such as the use of ductile, non‐reactive interlayers, transient liquid phase bonding, high‐plastic‐deformability braze fillers, and the optimization of both the intrinsic properties of ceramics and joint geometries. This overview provides valuable insights that extend beyond Ti‐alloy/non‐oxide‐ceramic joints, offering strategies applicable to the broader field of dissimilar material bonding.