bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chronic alcohol consumption augments loss of sialic acid residues and alters erythrocyte membrane charge in type II diabetic patients
Authors: Degirmenci Serkan , Akalin Aysen , Kartkaya Kazım , Kanbak Güngör 
Published: October 2008

AbstractIn this study, the effects of alcohol consumption on erythrocyte membrane properties in type 2 diabetic patients were investigated. Therefore, we measured total and lipid‐bound sialic acid (LSA) levels, sialidase activities, and erythrocyte membrane negative charge. Three groups, including control group (n = 20), alcohol‐consuming diabetic patients group (n = 14), and diabetic patients without alcohol consumption group (n = 42), were created. Plasma total sialic acid (TSA) levels of the alcohol‐consuming diabetic group were elevated as compared to the healthy control and diabetic group (p < 0.001 and p < 0.01, respectively). TSA levels of the diabetic group were significantly elevated as compared to the healthy control group (p > 0.001). Plasma LSA levels of the alcohol‐consuming diabetic group were higher than that in the healthy control and diabetic group (p < 0.05 and p < 0.05, respectively). LSA levels of the diabetic group were found to be high as compared to the healthy control group (p < 0.05). Plasma sialidase activities of the alcohol‐consuming diabetic group and diabetic group were significantly elevated as compared to the healthy control group (p < 0.05 and p < 0.05, respectively). Sialidase activities of the alcohol‐consuming diabetic group were elevated as compared to the diabetic group, but this was not statistically significant (p > 0.05). Erythrocyte membrane negativity levels of the alcohol‐consuming diabetic group and diabetic group were significantly decreased (p < 0.001 and p < 0.001, respectively) as compared to the healthy control group. Erythrocyte membrane negativity levels of the alcohol‐consuming diabetic group were decreased as compared to the diabetic group, but this was not statistically significant (p > 0.05). In conclusion, our results indicate that chronic alcohol consumption may augment membrane alterations in type 2 diabetic patients. © 2008 Wiley Periodicals, Inc. J Biochem Mol Toxicol 22:320–327, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/jbt.20243
Lymphoma of the testis and epididymis mimics chronic inflammation upon sonography
Authors: Yang Dal Mo , Kim Hyun Cheol , Jin Wook , Lee Hyung Lae , Kim Gyo Young 
Published: October 2008

AbstractWe report the sonographic findings in a case of lymphoma, which mimicked chronic inflammation. Scrotal gray‐scale sonography revealed an irregularly margined, hypoechoic mass in the right testis and epididymis. Color Doppler sonography showed increased blood flow within the hypoechoic lesions in both testis and epididymis. Pathologic examination revealed a diffuse involvement of the testis and epididymis. © 2008 Wiley Periodicals, Inc. J Clin Ultrasound, 2009
Minimum detectable change in motor and prefrontal cortex activity over repeated sessions using 3T functional MRI and a block design
Authors: Goodyear Bradley G. , Douglas Erin A. 
Published: October 2008

AbstractPurposeTo determine the minimum detectable change (MDC) in functional magnetic resonance imaging (fMRI) measurements of brain activity over repeated sessions with 95% confidence using a block design of tasks.Materials and MethodsFourteen individuals participated in three sessions on different days during which four scans each of a motor task and working memory task were performed. Using a region‐of‐interest analysis of variance, we calculated the MDC in the volume of activated primary sensorimotor cortex (for motor) and dorsolateral prefrontal cortex (for working memory), as well as the percent increase in MR signal and the center and location of maxima of the activated voxels.ResultsThe MDC of activated volume was 5.0–8.8 cm3, and the MDC of percent increase in signal from baseline during tasks was 0.3%–0.6%. The MDC of the center of mass of activity was 3–4 mm, compared to 6–10 mm for the location of maxima.ConclusionfMRI measurements that quantify the strength of activity in response to tasks and centers of mass offer sensitive measurements of change over repeated imaging sessions. fMRI can be used for serial investigations of individual participants using simple motor and cognitive tasks using a simple block design. J. Magn. Reson. Imaging 2008;28:1055–1060. © 2008 Wiley‐Liss, Inc.
128‐channel body MRI with a flexible high‐density receiver‐coil array
Authors: Hardy Christopher J. , Giaquinto Randy O. , Piel Joseph E. , Rohling AAS Kenneth W. , Marinelli Luca , Blezek Daniel J. , Fiveland Eric W. , Darrow Robert D. , Foo Thomas K.F. 
Published: October 2008

AbstractPurposeTo determine whether the promise of high‐density many‐coil MRI receiver arrays for enabling highly accelerated parallel imaging can be realized in practice.Materials and MethodsA 128‐channel body receiver‐coil array and custom MRI system were developed. The array comprises two clamshells containing 64 coils each, with the posterior array built to maximize signal‐to‐noise ratio (SNR) and the anterior array design incorporating considerations of weight and flexibility as well. Phantom imaging and human body imaging were performed using a variety of reduction factors and 2D and 3D pulse sequences.ResultsThe ratio of SNR relative to a 32‐element array of similar footprint was 1.03 in the center of an elliptical loading phantom and 1.7 on average in the outer regions. Maximum g‐factors dropped from 5.5 (for 32 channels) to 2.0 (for 128 channels) for 4 × 4 acceleration and from 25 to 3.3 for 5 × 5 acceleration. Residual aliasing artifacts for a right/left (R/L) reduction factor of 8 in human body imaging were significantly reduced relative to the 32‐channel array.ConclusionMRI with a large number of receiver channels enables significantly higher acceleration factors for parallel imaging and improved SNR, provided losses from the coils and electronics are kept negligible. J. Magn. Reson. Imaging 2008;28:1219–1225. © 2008 Wiley‐Liss, Inc.
Ability of diffusion‐weighted imaging for the differential diagnosis between chronic expanding hematomas and malignant soft tissue tumors
Authors: Oka Kiyoshi , Yakushiji Toshitake , Sato Hiro , Yorimitsu Shigeta , Hayashida Yoshiko , Yamashita Yasuyuki , Mizuta Hiroshi 
Published: October 2008

AbstractPurposeTo evaluate the potential of diffusion‐weighted imaging (DWI) in distinguishing chronic expanding hematomas (CEHs) from malignant soft tissue tumors.Materials and MethodsWe performed conventional MRI and DWI of six CEHs and 31 malignant soft tissue tumors from 37 patients seen between May 2000 and November 2006. DWI was obtained with a single‐shot echo‐planar imaging (EPI) sequence using a 1.5T MR imager. The mean apparent diffusion coefficient (ADC) value was also calculated. We evaluated MRI findings of CEHs and compared ADC value of CEHs with malignant soft tissue tumors.ResultsOn conventional MRI, two of six CEHs were difficult to differentiate from malignant soft tissue tumors based on imaging findings. The mean ADC value of CEHs and malignant soft tissue tumors was 1.55 ± 0.121 × 10−3 mm2/sec and 0.92 ± 0.139 × 10−3 mm2/sec (mean ± SD), respectively. The mean ADC value of CEHs was significantly higher than that of malignant soft tissue tumors (P < 0.01). There was no overlap in the minimum ADC values among CEHs and malignant soft tissue tumors.ConclusionDWI is useful for differentiating between CEHs and malignant soft tissue tumors. J. Magn. Reson. Imaging 2008;28:1195–1200. © 2008 Wiley‐Liss, Inc.
Prostate magnetic resonance imaging: Multiexponential T2 decay in prostate tissue
Authors: Storås Tryggve H. , Gjesdal Kjell‐Inge , Gadmar Øystein B. , Geitung Jonn T. , Kløw Nils‐Einar 
Published: October 2008

AbstractPurposeTo investigate the T2 decay in prostate tissue for multiexponentiality and to assess how the biexponential model relates to established T2W contrast.Materials and MethodsA 32‐echo spin‐echo sequence was performed on 16 volunteers. Six single‐voxel decay curves were sampled from each prostate. Prediction accuracies were assessed by jackknifing for the mono‐, bi‐, and triexponential models. The differences were evaluated by cross‐validated analysis of variance (CVANOVA). Multiple linear regression was performed to assess the relation between parameters in the biexponential model and the contrast in T2W images.ResultsMono‐, bi‐, and triexponential models were preferred in 8 (10%), 72 (86%), and 4 (5%) cases, respectively. The biexponential short T2 was 64 msec (range 43 to 92 msec) and the long T2 was 490 msec (range 161 to 1319 msec). The fitted signal fraction, f, of the long T2 component was 27% (range 3% to 80%). The adjusted R2 was 75.1% for the full regression model and decreased by 0.9%, 1.3%, and 39.2% when short T2, long T2, and f were removed from the model, respectively.ConclusionProstatic T2 decay was, in general, biexponential. The differences between the T2 components were large enough for accurate quantification. The T2W image contrast was primarily predicted by the biexponential signal fractions. J. Magn. Reson. Imaging 2008;28:1166–1172. © 2008 Wiley‐Liss, Inc.
Method for rapid calculation of quantitative cerebral perfusion
Authors: Shah Maulin K. , Shin Wanyong , Mouannes Jessy , Shaibani Ali , Horowitz Sandra W. , Carroll Timothy J. 
Published: October 2008

AbstractPurposeTo evaluate an algorithm based on algebraic estimation of T1 values (three‐point estimation) in comparison with computational curve‐fitting for the postprocessing of quantitative cerebral perfusion scans.Materials and MethodsComputer simulations were performed to quantify the magnitude of the expected error on T1 and consequently cerebral perfusion using the three‐point estimation technique on a Look‐Locker (LL) EPI scan. In 50 patients, quantitative cerebral perfusion was calculated using the bookend method with three‐point estimation and curve‐fitting. The bookend method, a novel approach for calculating quantitative cerebral perfusion based on changes in T1 values after a contrast injection, is currently being validated. The number of computations was used as a measure of computation speed for each method. Student's paired t‐test, Bland‐Altman, and correlation analyses were performed to evaluate the accuracy of estimation.ResultsThere was a 99.65% reduction in the number of computations with three‐point estimation. Student's t‐test showed no significant difference in cerebral perfusion (P = 0.80, 0.49, paired t‐test N = 50, quantitative cerebral blood flow–white matter [qCBF‐WM], qCBF–gray matter [qCBF‐GM]) when compared to curve‐fitting. The results of the two techniques were strongly correlated in patients (slope = 0.99, intercept =1.58 mL/(100 g/minute), r = 0.86) with a small systemic bias of −0.97 mL/(100 g/minute) in Bland‐Altman analysis.ConclusionThe three‐point estimation technique is adequate for rapid calculation of qCBF. The estimation scheme drastically reduces processing time, thus making the method feasible for clinical use. J. Magn. Reson. Imaging 2008;28:1258–1265. © 2008 Wiley‐Liss, Inc.
Improved delayed enhanced myocardial imaging with T2‐Prep inversion recovery magnetization preparation
Authors: Liu Chia‐Ying , Wieben Oliver , Brittain Jean H. , Reeder Scott B. 
Published: October 2008

AbstractPurposeTo develop a magnetization preparation method that improves the differentiation of enhancing subendocardial infarction (MI) from ventricular blood for myocardial delayed‐enhancement (DE) magnetic resonance imaging (MRI).Materials and MethodsT2Prep‐IR is a magnetization preparation pulse that consists of a T2 preparation (T2Prep) followed immediately by a nonselective inversion recovery (IR) pulse. The first imaging excitation is then delayed an inversion time (TI) to allow nulling of normal myocardium in DE study. The amount of T2 contrast is determined by the effective echo time of the T2Prep pulse, TEeff. TEeff is selected to differentiate MI and blood that share similar T1 values but have different T2 values. The T2Prep‐IR preparation was incorporated into a fast gradient echo sequence to produce an image with both T1 and T2 weighting. Simulations predict that this method will generate improved contrast between MI and chamber blood compared to conventional IR methods.ResultsComparisons between images acquired using conventional IR and T2Prep‐IR in patients with MI indicate that this new approach significantly improves the blood‐MI contrast (122 ± 32% higher than that of IR with P < 0.05).ConclusionOur preliminary patient studies confirm that this preparation is helpful for improved delineation of subendocardial infarction. J. Magn. Reson. Imaging 2008;28:1280–1286. © 2008 Wiley‐Liss, Inc.
Parallel MRI with extended and averaged GRAPPA kernels (PEAK‐GRAPPA): Optimized spatiotemporal dynamic imaging
Authors: Jung Bernd , Ullmann Peter , Honal Matthias , Bauer Simon , Hennig Jürgen , Markl Michael 
Published: October 2008

AbstractPurposeTo evaluate an optimized k‐t‐space related reconstruction method for dynamic magnetic resonance imaging (MRI), a method called PEAK‐GRAPPA (Parallel MRI with Extended and Averaged GRAPPA Kernels) is presented which is based on an extended spatiotemporal GRAPPA kernel in combination with temporal averaging of coil weights.Materials and MethodsThe PEAK‐GRAPPA kernel consists of a uniform geometry with several spatial and temporal source points from acquired k‐space lines and several target points from missing k‐space lines. In order to improve the quality of coil weight estimation sets of coil weights are averaged over the temporal dimension.ResultsThe kernel geometry leads to strongly decreased reconstruction times compared to the recently introduced k‐t‐GRAPPA using different kernel geometries with only one target point per kernel to fit. Improved results were obtained in terms of the root mean square error and the signal‐to‐noise ratio as demonstrated by in vivo cardiac imaging.ConclusionUsing a uniform kernel geometry for weight estimation with the properties of uncorrelated noise of different acquired timeframes, optimized results were achieved in terms of error level, signal‐to‐noise ratio, and reconstruction time. J. Magn. Reson. Imaging 2008;28:1226–1232. © 2008 Wiley‐Liss, Inc.
Cross‐correlation delay to quantify myocardial dyssynchrony from phase contrast magnetic resonance (PCMR) velocity data
Authors: Delfino Jana G. , Fornwalt Brandon K. , Eisner Robert L. , Leon Angel R. , Oshinski John N. 
Published: October 2008

AbstractPurposeTo apply cross‐correlation delay (XCD) analysis to myocardial phase contrast magnetic resonance (PCMR) tissue velocity data and to compare XCD to three established “time‐to‐peak” dyssynchrony parameters.Materials and MethodsMyocardial tissue velocity was acquired using PCMR in 10 healthy volunteers (negative controls) and 10 heart failure patients who met criteria for cardiac resynchronization therapy (positive controls). All dyssynchrony parameters were computed from PCMR velocity curves. Sensitivity, specificity, and receiver operator curve (ROC) analysis for separating positive and negative controls were computed for each dyssynchrony parameter.ResultsXCD had higher sensitivity (90%) and specificity (100%) for discriminating between normal and patient groups than any of the time‐to‐peak dyssynchrony parameters. ROC analysis showed that XCD was the best parameter for separating the positive and negative control groups.ConclusionXCD is superior to time‐to‐peak dyssynchrony parameters for discriminating between subjects with and without dyssynchrony and may aid in the selection of patients for cardiac resynchronization therapy. J. Magn. Reson. Imaging 2008;28:1086–1091. © 2008 Wiley‐Liss, Inc.
Time‐resolved dynamic contrast‐enhanced MR urography for the evaluation of ureteral peristalsis: Initial experience
Authors: Kim Sooah , Jacob Jason S. , Kim Danny C. , Rivera Rafael , Lim Ruth P. , Lee Vivian S. 
Published: October 2008

AbstractPurposeTo determine the feasibility of time‐resolved dynamic contrast‐enhanced magnetic resonance urography (MRU) for the evaluation of ureteral peristalsis using a data‐sharing 3D gradient echo sequence with spiral k‐space filling.Materials and MethodsEight patients (M = 3, F = 5, mean 48.1 years) were referred for MRU for the evaluation for renal mass (n = 3), hematuria (n = 2), urinary tract tuberculosis (n = 1), postoperative bladder cancer (n = 1), and postoperative ureteric reimplantation (n = 1). Dynamic MRU was performed for 120 seconds at 1.5T after intravenous furosemide and gadolinium administration using an oblique sagittal, time‐resolved T1 3D gradient echo sequence with 1 second effective temporal resolution. Study quality was assessed based on artifacts and extent of ureteric visualization. Frequency of peristalsis from the renal pelvis to urinary bladder was evaluated for each subject.ResultsA total of 16 ureters were examined. Image quality was good in four ureters, satisfactory in 11 ureters, and poor in one ureter. Mean peristaltic frequency was 3.5 waves per minute (range, 2.5–6.5 waves/minute) in normal ureters (n =11). Five ureters were considered abnormal (one urinary tract tuberculosis and four postsurgical ureters), and all had decreased or no peristalsis (0–1.5 waves per minute).ConclusionMRU using a time‐resolved, data‐sharing 3D contrast‐enhanced technique is able to demonstrate ureteral peristalsis and permits quantification of ureteral peristaltic frequency. J. Magn. Reson. Imaging 2008;28:1293–1298. © 2008 Wiley‐Liss, Inc.
Enhanced mass on contrast‐enhanced breast MR imaging: Lesion characterization using combination of dynamic contrast‐enhanced and diffusion‐weighted MR images
Authors: Yabuuchi Hidetake , Matsuo Yoshio , Okafuji Takashi , Kamitani Takeshi , Soeda Hiroyasu , Setoguchi Taro , Sakai Shuji , Hatakenaka Masamitsu , Kubo Makoto , Sadanaga Noriaki , Yamamoto Hidetaka , Honda Hiroshi 
Published: October 2008

AbstractPurposeTo evaluate the diagnostic accuracy of a combination of dynamic contrast‐enhanced MR imaging (DCE‐MRI) and diffusion‐weighted MR imaging (DWI) in characterization of enhanced mass on breast MR imaging and to find the strongest discriminators between carcinoma and benignancy.Materials and MethodsWe analyzed consecutive breast MR images in 270 patients; however, 13 lesions in 93 patients were excluded based on our criteria. We analyzed tumor size, shape, margin, internal mass enhancement, kinetic curve pattern, and apparent diffusion coefficient (ADC) values. We applied univariate and multivariate analyses to find the strongest indicators of malignancy and calculate a predictive probability for malignancy. We added the corresponding categories to these prediction probabilities for malignancy and calculated diagnostic accuracy when we consider category 4b, 4c, and 5 lesions as malignant and category 4a, 3, and 2 lesions as benign. In a validation study, 75 enhancing lesions in 71 patients were examined consecutively.ResultsIrregular margin, heterogeneous internal enhancement, rim enhancement, plateau time–intensity curve (TIC) pattern, and washout TIC pattern were the strongest indicators of malignancy as well as past studies, and ADC values less than 1.1 × 10−3 mm2/s were also the strongest indicators of malignancy. In a validation study, sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were 92% (56/61), 86% (12/14), 97% (56/58), 71% (12/17), and 91% (68/75), respectively.ConclusionThe combination of DWI and DCE‐MRI could produce high diagnostic accuracy in the characterization of enhanced mass on breast MR imaging. J. Magn. Reson. Imaging 2008;28:1157–1165. © 2008 Wiley‐Liss, Inc.
Diagnostic accuracy of diffusion‐weighted imaging in differentiating benign from malignant ovarian lesions
Authors: Fujii Shinya , Kakite Suguru , Nishihara Keisuke , Kanasaki Yoshiko , Harada Tasuku , Kigawa Junzo , Kaminou Toshio , Ogawa Toshihide 
Published: October 2008

AbstractPurposeTo clarify the diagnostic accuracy of diffusion‐weighted imaging (DWI) in differentiating benign from malignant ovarian lesions.Materials and MethodsWe retrospectively analyzed magnetic resonance images of 123 ovarian lesions in 119 patients. We defined lesions with abnormal signal intensity as malignancy and assessed the location of abnormal intensity within the lesions on DWI. We also assessed the mean and lowest apparent diffusion coefficient (ADC) values of the solid portion for each ovarian lesion.ResultsThe majority of malignant ovarian tumors and mature cystic teratomas, and almost half of the endometriomas, showed abnormal signal intensity on DWI, whereas most fibromas and other benign lesions did not. The main locations of abnormal signal intensity were solid portions in malignant ovarian tumors, cystic components suggestive of keratinoid substances and Rokitansky protuberance in mature cystic teratomas, and intracystic clots in endometriomas. On DW imaging, receiver‐operating characteristic analysis yielded mean Az values of 0.703. There was no significant difference in mean and lowest ADC values between malignant and benign lesions.ConclusionDWI of ovarian lesions and ADC values of the solid component are not useful for differentiating benign from malignant ovarian lesions. This knowledge is essential in avoiding misinterpretation in the diagnosis of ovarian lesions. J. Magn. Reson. Imaging 2008;28:1149–1156. © 2008 Wiley‐Liss, Inc.
Advanced imaging findings and computer‐assisted surgery of suspected synovial chondromatosis in the temporomandibular joint
Authors: Hohlweg‐Majert Bettina , Metzger Marc C. , Böhm Joachim , Muecke Thomas , Schulze Dirk 
Published: October 2008

AbstractSynovial chondromatosis of the joint occurs mainly in teenagers and young adults. Only 3% of these neoplasms are located in the head and neck region. Synovial chondromatosis of the temporomandibular joint is therefore a very rare disorder. Therefore, developing a working, histological confirmation is required for differential diagnosis. In this case series, the outcome of histological investigation and imaging techniques are compared. Based on clinical symptoms, five cases of suspected synovial chondromatosis of the temporomandibular joint are presented. In each of the subjects, the diagnosis was confirmed by histology. Specific imaging features for each case are described. The tomography images were compared with the histological findings. All patients demonstrated preauricular swelling, dental midline deviation, and limited mouth opening. Computer‐assisted surgery was performed. Histology disclosed synovial chondromatosis of the temporomandibular joint in four cases. The other case was found to be a developmental disorder of the tympanic bone. The diagnosis of synovial chondromatosis of the temporomandibular joint can only be based on histology. Clinical symptoms are too general and the available imaging techniques only show nonspecific tumorous destruction, infiltration, and/or residual calcified bodies, they are only for advanced cases. A rare developmental disorder of the tympanic bone—persistence of foramen of Huschke—has to be differentiated. J. Magn. Reson. Imaging 2008;28:1251–1257. © 2008 Wiley‐Liss, Inc.