bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploiting Gene Expression Signatures in Breast Cancer Cell Lines to Unveil Novel Drug Candidates and Synergistic Combinations
Authors: Liu Hsueh-Chuan , Weng Chia-Wei , Ng Ka-Lok 
Published: February 2025

Aim:
This study aimed to study breast cancer, the most common cancer affecting women
worldwide, using one primary and two metastatic breast tumor cell lines to identify therapeutic
drugs.

Background:
Investigating the changes in gene expression triggered by drugs offers a robust method
for uncovering potential new treatments. Through the analysis of the impacts of drugs on gene activity,
scientists can unravel the molecular mechanisms within cells, comprehend the effects of
drugs, identify chances for drug repositioning, and foresee patient outcomes to treatments.

Objective:
Our approach has involved two main strategies: analyzing drug-perturbed gene expression
profiles and leveraging drug-induced gene expression profiles. Firstly, we have assessed how
drugs affect the expression of target genes in a dose-dependent manner, determining whether they
inhibit or activate gene expression. This analysis could inform the identification of new potential
drugs. Secondly, we have grouped drugs based on their expression profiles to explore potential synergistic
effects.

Methods:
Our methodology has involved quantifying gene profile changes relative to drug dosage,
categorizing effects as up-regulating or down-regulating, and employing functional enrichment with
cancer hallmark annotations to predict drugs with potential for cancer treatment. Additionally, we
have determined the optimal number of drug groups with similar effects on gene expression and explored
their mechanisms of action through cancer hallmark annotations.

Results:
By analyzing dose-dependent gene expression, we have found that seven, three, and five
drugs may induce similar sets of up-regulated and down-regulated genes in Hs-578-T, MCF7, and
MDA-MB-231 cell lines, respectively. Clustering and functional enrichment analyses have suggested
a shared molecular mechanism of action among these drug candidates.

Conclusion:
We have thus categorized drugs with opposing gene expression profiles and proposed
new drug candidates for breast cancer treatment based on cancer hallmark annotations. Moreover,
our study has uncovered synergistic drug combinations, including those utilizing FDA-approved
drugs, for primary and metastatic breast cancer cell lines.
Analysis of SCB-DB Algorithm for Various Characteristic Parameters
Authors: Thakur Diksha , baghel Vikas , Talluri salman Raju 
Published: February 2025

Introduction:
The performance of a standard Capon beamformer for dual beams (SCBDB)
is analyzed against simultaneous variations in the direction and power of interference. The
performance metrics of SCB-DB are SLL, maximum SLL, 3-dB beamwidth and beamwidth between
first minimas.

Method:
In SCB-DB, the standard SCB utilizes an extra constraint to ensure that unity gain is preserved
for the second desired signal. The SLL management, along with dual beams (SCB −
DBSLL), involves the sampling of angles within the sidelobe area, and the powers associated with
these sampled angles are restricted to a predetermined level.

Results:
The SCB − DBSLL configuration demonstrated notable enhancements, achieving approximately
a 63% reduction in side lobe levels for both beams, decreasing from -8 dB to -21.846 dB.

Conclusion:
Additionally, maximum SLL improved by 64% lowering from -5.48 dB to -9 dB.
Identifying High-Priority Ethical Challenges for Precision Emergency Medicine: Nominal Group Study
Authors: Rose Christian , Shearer Emily , Woller Isabela , Foster Ashley , Ashenburg Nicholas , Kim Ireh , Newberry Jennifer 
Published: February 2025

Abstract

Background
Precision medicine promises to revolutionize health care by providing the right care to the right patient at the right time. However, the emergency department’s unique mandate to treat “anyone, anywhere, anytime” creates critical tensions with precision medicine’s requirements for comprehensive patient data and computational analysis. As emergency departments serve as health care’s safety net and provide a growing proportion of acute care in America, identifying and addressing the ethical challenges of implementing precision medicine in this setting is crucial to prevent exacerbation of existing health care disparities. The rapid advancement of precision medicine technologies makes it imperative to understand these challenges before widespread implementation in emergency care settings.

Objective
This study aimed to identify high priority ethical concerns facing the implementation of precision medicine in the emergency department.

Methods
We conducted a qualitative study using a modified nominal group technique (NGT) with emergency physicians who had previous knowledge of precision medicine concepts. The NGT process consisted of four phases: (1) silent generation of ideas, (2) round-robin sharing of ideas, (3) structured discussion and clarification, and (4) thematic grouping of priorities. Participants represented diverse practice settings (county hospital, community hospital, academic center, and integrated managed care consortium) and subspecialties (education, ethics, pediatrics, diversity, equity, inclusion, and informatics) across various career stages from residents to late-career physicians.

Results
A total of 12 emergency physicians identified 82 initial challenges during individual ideation, which were consolidated to 48 unique challenges after removing duplicates and combining related items. The average participant contributed 6.8 (SD 2.9) challenges. These challenges were organized into a framework with 3 themes: values, privacy, and justice. The framework identified the need to address these themes across 3 time points of the precision medicine process: acquisition of data, actualization in the care setting, and the after effects of its use. This systematic organization revealed interrelated concerns spanning from data collection and bias to implementation challenges and long-term consequences for health care equity.

Conclusions
Our study developed a novel framework that maps critical ethical challenges across 3 domains (values, privacy, and justice) and 3 temporal stages of precision medicine implementation. This framework identifies high-priority areas for future research and policy development, particularly around data representation, privacy protection, and equitable access. Successfully addressing these challenges is essential to realize precision medicine’s potential while preserving emergency medicine’s core mission as health care’s safety net.
Transfer Teknologi Tepat Guna Pada Industri Pengolahan Kopi Arabika
Authors: Lasmawan I Wayan , Suci I Made , I Wayan Pardi  , Muliarta I Nengah , Marsakawati Ni Putu Era 
Published: February 2025

Desa Belantih merupakan salah satu desa yang memiliki potensi besar pada bidang perkebunan kopi. Belantih Coffee Farm dan Kelompok Tani Dharma Kriya merupakan dua industri pengolahan Kopi Arabika Kintamani yang ada di Desa Belantih. Akan tetapi dalam menjalankan usahanya kedua mitra menghadapi berbagai permasalahan yaitu kedua mitra tidak memiliki mesin pulper, dan huller. Metode pemasaran yang digunakan oleh mitra hanya mengandalkan teman di whatapp grup atau teman dekat, serta dengan metode pemasaran dari mulut ke mulut. Metode yang digunakan dalam kegiatan pengabdian ini adalah Particiatory Action and Learning System (PALS). Terdapat beberapa kegiatan yang dilaksanakan untuk mengoptimalkan potensi dan menyelesaikan permasalahan yang dihadapi oleh kedua mitra, yakni transfer teknologi tepat guna berupa mesin pulper kepada UMKM Belantih Coffee Farm dan mesin huller kepada Kelompok Tani Dharma Kriya, pelatihan fotografi dan videografi produk, pelatihan pembuatan konten pemasaran (copywriting), pelatihan social media marketing, dan pelatihan marketpalce usaha kepada kedua mitra. Kedua mitra mampu menggunakan social media untuk mempromosikan produk kopi arabika Kintamani. Kedua mitra mampu menggunakan marketpalce berupa shopee untuk mempromosikan produk kopi arabika Kintamani.
Penguatan Kompetensi Design Thinking dan Pengendalian Emosi Guru
Authors: Ni Wayan Rati  , I Wayan Widiana  , Anak Agung Istri Dewi Adhi Utami  
Published: February 2025

Hasil observasi menunjukkan salah satu kendala dilapangan adalah bahwa guru-guru di SD inklusi ini menghadapi keterbatasan pengetahuan dan keterampilan dalam mengelola kebutuhan siswa berkebutuhan khusus. Para guru di SD inklusi sering menghadapi tantangan dalam mengimplementasikan pendekatan pembelajaran yang sesuai dengan kebutuhan khusus siswa. Guru-guru memiliki pengetahuan umum tentang kebutuhan khusus, tetapi mereka tidak memiliki pemahaman mendalam tentang kebutuhan individu setiap siswa. Salah satu upaya yang dapat dilakukan untuk mengatasi kendala tersebut adalah dengan memberikan pelatihan dan pendampingan Pendekatan design thinking. Pengabdian ini akan melaksanakan pelatihan pendekatan design thinking untuk guru-guru SD inklusi. Pelatihan akan mencakup konsep dasar design thinking, penerapannya dalam konteks pembelajaran siswa berkebutuhan khusus, serta praktik langsung dalam merancang pembelajaran yang inklusif. Dalam pelatihan, akan diberikan studi kasus, simulasi, dan diskusi interaktif untuk memastikan pemahaman dan penerapan konsep secara efektif. Menyediakan mentoring atau pendampingan setelah pelatihan untuk membantu guru-guru dalam menerapkan konsep design thinking dalam pengajaran sehari-hari. Program Pengabdian kepada Masyarakat (PkM) ini bertujuan untuk Memberikan pelatihan design thinking bagi guru di sekolah inklusi sehingga guru bisa mengajarkan siswa berkebutuhan khusus dengan lebih optimal serta memberikan pelatihan strategi mengajar dan pengendalian emosi guru guna memberikan perhatian untuk mendukung kesetaraan pendidikan inklusi dan mengurangi kesenjangan yang ada dilapangan. Program ini memiliki potensi untuk membantu guru untuk membuat perangkat pembelajaran berpendekatan design thinking.
Implementasi Teknologi IoT untuk Penyiraman Otomatis dalam Peningkatan Produksi Sayuran Tauge
Authors: Masrizal  , Amat Sofiyan  , Deasy Wahyuni  , Hayatullah Khumaini  
Published: February 2025

Mekanisme penyiraman dilakukan dengan sistem konvensional (sederhana) yaitu menggunakan pipa selang, air didalam pipa mempunyai tekanan yg bersumber dari pompa air terhubung dengan sumber air yaitu air sumur atau tampungan (reservoir). Keterbatasan alat penyiraman yang dimiliki mitra tersebut menjadi permasalahan selama ini, artinya mitra pengabdi tidak bisa bepergian meninggalkan tempat usaha. Penelitian ini bertujuan untuk menganalisis implementasi teknologi iot untuk penyiraman otomatis dalam peningkatan produksi sayuran tauge. Metode pelaksanaan kegiatan PMP. Jenis dan pendekatan yang dilakukan terhadap mitra adalah dengan memberikan sosialisasi dan edukasi tentang teknlogi yang bisa digunakan supaya usaha mereka tekuni sekarang bisa lebih efektif dalam penyiraman dengan menggunakan teknologi. Subjek dalam penelitian ini adalah penyiraman sayuran touge dengan menggunakan IoT dari permasalahan mitra sasaran ini diperlukan penyiraman sayuran touge secara otomatis menggunakan tekologi tepat guna, hasil dari pengabdian masyarakat ini adalah dengan adanya tekologi yang diterapkan diusaha rumahan tersebut touge bisa meningkatkan produksi dan kualitas sayuran touge yang baik untuk di pasaran untuk memenuhi permintaan konsumen. Implikasi penelitian ini yaitu pemantauan parameter sensor dan pengendalian juga dapat dilakukan lewat smartphone sehingga bisa membantu usaha touge kartini dalam meningkatkan hasil produksi yang diingikan.
PENGARUH PENERAPAN MEDIA WORDWALL TERHADAP HASIL BELAJAR SISWA
Authors: Rizki Wahida Arni Malau  , Siti Nurhayati  , Amin Fauzi  , Zulkifli Matondang  
Published: February 2025

ABSTRAK
Proses pembelajaran masih mencitai budaya lama sehingga esensi tujuan dari IPS masih kurang dipahami. Pemanfaatan media dalam pembelajaran kurang diterapkan sehingga membosankan. Penelitian ini bertujuan untuk mengetahui pengaruh media interkatif berbasis wordwall terhadap hasil belajar siswa. Jenis penelitian adalah penelitian kuantitatif dengan metode penelitian eksperimen yaitu Pre-Experimental Design Type One Group Pretest-Posttest Design. Penelitian dilakukan di SDN 101765 Bandar Setia. Sampel kelas V-B berjumlah 28 orang siswa. Teknik pengumpulan data yaitu wawancara, tes dan dokumentasi. Hasil penelitian rata-rata hasil pretes adalah 57,5 dan postest adalah 83,75. Hasil paired samples Correlations adalah 0.548 dan maka disimpulkan terdapat hubungan antara pretest dan postest yang erat. Hasil uji hipotesis yaitu besar signifikan (2-tailed) 0,000 yang berarti sig.(2- tailed)<0,05, maka H0 ditolak dan Ha diterma. Dapat disimpulkan bahwa Ada perbedaan antara pembelajaran konvesional dan pembelajaran berbasis interaktif terhadap hasil belajar siswa pada suatu materi energi dan perubahannya.
Kata Kunci: Wordwall, Hasil belajar, Pembelajaran IPS
Household savings in Poland – size, structure, and main determinants
Authors: Olszewska Grażyna A. 
Published: February 2025

Household savings are major elements that determine, alongside other factors, the equilibrium in the financial market and thus in the national economy. They are an important macroeconomic variable and a potential source of investments and economic growth. They play a major role in the money circulation in the economy and create conditions for the normal functioning of both the whole market and the households themselves. Given the macro- and microeconomic significance of the savings, they are discussed at length in specialist literature. Their volume and structure are affected by a broad variety of factors, both subjective and objective, internal and external, those connected with the macro- and micro-environment (Harasim, 2010, pp. 29-30). They can be analysed from the perspective of factors determining the decisions of an individual household, where qualitative factors are important, and of macroeconomic equilibrium, where quantitative factors and conditions prevail. In the case of individual household decisions, these are inter alia financial, fiscal, economic, legal, technological, demographic, psychological, sociological, educational, and cultural factors. The literature classifies them in diverse ways, depending on criteria adopted by a given author. The major schools of economics claim economic crises are as a rule accompanied by increasing rates of household savings. This is primarily, though not exclusively, due to precautionary measures. The size and structure of household savings in Poland have changed in recent years. The pandemic experience suggests the emergence of savings which are as if forced by a reducing ‘activity’ of households. The war in Ukraine is an additional factor affecting not so much the volume as the structure of the savings. This paper is an attempt at answering the question to what extent these factors have determined the size and structure of household savings in Poland. The following research methods are applied: a review of literature and state of the art on household savings in the Polish economy, a diagnosis and interpretation of available data concerning the volume and structure of household savings in Poland.
Winning the innovation race: Insights from game theory and microeconomics
Authors: Kalisty Klaudiusz , Dudziuk Iwona 
Published: February 2025

This study examines the impact of first-mover advantage on firms' innovation processes from a microeconomic perspective, with a particular focus on game theory and the game of chicken. The primary research question is to ascertain how the timing of innovation affects a firm's competitive advantage. The objective of the study is to gain insight into the factors that contribute to a successful first-mover strategy and to elucidate the manner in which these factors interact within the framework of game theory. Methodologically, the study employs game theory to analyse strategic decision-making in innovation, with a particular focus on the game of chicken to illustrate conflict scenarios in which firms compete for market advantage. The research examines the characteristics of firms, markets and products through a review of the literature in order to identify the key variables that contribute to first-mover advantage. The findings demonstrate that a number of internal factors (such as managerial capacity for innovation and the firm's overall innovation capability), external factors (including participation in innovation networks and market orientation) and product characteristics (such as product class and environmental awareness) are significantly associated with an increased likelihood of a firm achieving first-mover advantage. In conclusion, the study confirms that firms that effectively manage these factors gain a competitive advantage by being the first to market.
Domsettend, worulddema or dempster? Medieval English references to the noun judge
Authors: Każmierczak Małgorzata 
Published: February 2025

The aim of the present brief study is to review selected Medieval English lexical representations of the noun judge ‘one who tries cases and interprets the laws’ (MED) and their semantic development in the history of English (cf. OE domsettend, dempster, worulddema). The study uses standard databases, such as Bosworth−Toller’s Anglo-Saxon Dictionary (B−T), Clark Hall’s A Concise Anglo-Saxon Dictionary (CASD), Dictionary of Old English Corpus (DOEC), Dictionary of the Older Scottish Tongue (DOST), Historical Thesaurus of English (HTE), The Innsbruck Corpus of Middle English Prose (ICoMEP), Middle English Dictionary (MED), the Oxford English Dictionary (OED), Scottish National Dictionary (SND), Thesaurus of Old English (TOE), A Thesaurus of English Word Roots (TEWR), Collins Dictionary (CD) and Merriam-Webster Dictionary (MWD).
A preliminary search for the terms in question confirms either their decline shortly after being first recorded in Old English (cf. domsettend, gesetla, worulddema) or their survival into the Middle or Early Modern English periods (cf. doomer, doomsman, judger). Only two nouns, judge and jurist, have survived beyond Medieval English and are frequent in current use.
A Text-Based Approach in English for Arts and Design: An ESP Course Design
Authors: Marsakawati Ni Putu Era 
Published: February 2025

English for arts and design is a vocational English developed to facilitate non-English students, studying visual design communication. The goal of the course is to enable the students to use English and communicate effectively in the context of visual design business. To achieve this learning goal, the lecturer should design a meaningful and effective course design. Among various approaches to ESP course design, this article describes the text-based approach. Because the students are from a non-English department, this strategy will help them learn English more effectively. When the lecturer uses this approach, they provide students with sufficient scaffolding. These scaffolding are useful for assisting students to gain confidence in using English. Gradually, their learning goals can be achieved effectively. Thus, this article aims to describe how to design an effective ESP course for Visual Design Communication students and report its implementation in the classroom. This paper will hopefully provide some practical insights in designing ESP courses and in using text-based approach in ESP classrooms.
Design and Development of a Solar-Powered Rotary Drum Composter for Managing Food-Waste at the University Food Center
Authors: Danga Ma. Angelica B. , Lim John Kevin C. , Jingco Jude Milbert C. , Manalo Justine Roi P. , Marquez Joshua G. , Tangcuangco Alma L. , Tiria Genesis M. , Macaspac Jezeth Vince B. 
Published: February 2025

The annual value of food waste generated worldwide already reached a staggering $1 trillion. This amounts to 1.3 – 1.4 billion tonnes or one third of food produced for human consumption that goes to waste each year. The Food Center at Don Honorio Ventura State University faces a similar issue a weekly production of 21.5kg of food waste. To address this increasingly concerning issue, a solar-powered rotary drum composter driven by a DC motor was developed. This composter, designed to accommodate up to 20kg of food waste. Analysis of the composter's motor performance reveals significant relationships between voltage, current, speed, torque, efficiency and load. The voltage exhibits an inverse proportional relationship with load, steadily decreasing from 24.8V to 23.3V as the load increases, while the current shows a direct proportional relationship, consistently rising from 4.1A to 9.84A with increased load. Further examination of torque and speed in relation to load indicates a direct and inverse proportional relationship, respectively. Torque increases from 6.68Nm to 27.23Nm with increasing load, meanwhile, speed decreased from 72.74rpm to 55.16rpm. As for the efficiency, it was found out that the composter operates most efficiently when the drum is loaded 12kg, beyond which efficiency gradually declines with increasing load up to 20kg. This decline signifies the diminishing returns associated with higher loads, highlighting the importance of load optimization for sustained efficiency in composter operation.
The Inter-Services Public Relations Creating Narratives through Visuals: Pakistan’s Nation branding and Public Diplomacy
Authors: Rai Maleeha , Azam Dr. Maryam 
Published: February 2025

In Pakistan, the Inter-Service Public Relation (ISPR) Media wing of Armed Forces in Pakistan has historically been considered as an institution that is sufficiently delivering to change the false narrative about Pakistan. The international image of Pakistan was being linked to unsafe country because of terrorism, religious extremism, and presumed branding as a failed state. There was a need to change the image of Pakistan internationally. States now adopt nation-branding and public diplomacy strategies to safeguard their national interests and to maintain their good image internationally. This paper would discuss that how the strategies of nation branding and public diplomacy enhanced the image of Pakistan and which variables Pakistan used for developing favorable public perception and country branding.