bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neonatal Diabetes With End-Stage Nephropathy
Authors: Esmatjes Enric , Jimenez Amanda , Diaz Gonzalo , Mora Mireia , Casamitjana Roser , Pérez de Nanclares G. , Castaño Luis , José Ricart Maria 
Published: August 2008

OBJECTIVE—To describe the diagnosis of a patient with neonatal diabetes who had been misdiagnosed with type 1 diabetes and referred to our hospital for pancreas and kidney transplantation because of end-stage renal disease.
RESEARCH DESIGN AND METHODS—A diagnosis of neonatal diabetes was made after a molecular genetic study revealed a mutation in exon 34 of the ABCC8 gene. Pancreas transplantation was ill-advised.
RESULTS—The patient was switched from insulin to glibenclamide 4 months after kidney transplantation, confirming that pancreas transplantation would not have been a good decision.
CONCLUSIONS—This is the first report of a patient with neonatal diabetes who developed diabetic nephropathy that progressed to end-stage renal disease. This report illustrates that careful endocrinological evaluation, including molecular genetic studies, if necessary, is mandatory before a decision to perform a pancreas transplant is made.
Mahovna Flora Smrekovškega Pogorja (Kamniško-Savinjske Alpe, Slovenija)
Authors: Martinčič Andrej 
Published: August 2008

Mahovna Flora Smrekovškega Pogorja (Kamniško-Savinjske Alpe, Slovenija)The study gives results on new bryophyte records of Smrekovško pogorje Mts. as well as the previous reports from the literature. In total 229 species are reported from the investigated region, 173 mosses and 56 liver-worts. Among them 3 are reported for the first time for Slovenia (Sciuro-hypnum oedipodium, Calypogeia integristipula, Lophozia sudetica), 20 species are reported for the first time for the Kamniško-Savinjske Alps (Alpine phytogeographical region of Slovenia). 26 species are included in the national Red List and 4 species in the Red Data Book of European Bryophytes (ECCB 1995), in the rare (R) category:Scapania verrucosa, Brachythecium geheebii, Fissidens asplenioidesandParaleucobryum sauteri.
Photoresponsive Glass‐Forming Butadiene‐Based Chiral Liquid Crystals with Circularly Polarized Photoluminescence
Authors: Vijayaraghavan Ratheesh K. , Abraham Shibu , Akiyama Haruhisa , Furumi Seiichi , Tamaoki Nobuyuki , Das Suresh 
Published: August 2008

AbstractThe synthesis and study of the photo‐ and thermoresponsive behavior of a series of novel trimesogens consisting of a diphenylbutadiene core linked to cholesterol moieties on either side via flexible alkyl chains are reported. These molecules possess the combined glass‐forming properties of bischolesterols and the photochromic and luminescent properties of the butadiene moiety. The pitch of the cholesteric phase of these materials could be continuously varied thermally and photochemically, making it possible to tune the color of the film over the entire visible region. The color images thus generated could be stabilized by converting them to N* glasses. These materials were also highly photoluminescent, exhibiting circularly polarized characteristics in the glassy liquid‐crystalline state even by linearly polarized excitation.
Effect of the origin of ZnO nanoparticles dispersed in polyimide films on their photoluminescence and thermal stability
Authors: Somwangthanaroj Anongnat , Phanthawonge Chuthatai , Ando Shinji , Tanthapanichakoon Wiwut 
Published: August 2008

AbstractPolyimide (PI) films containing dispersed ZnO nanoparticles were prepared from both zinc nitrate hexahydrate (designated as Zn(NO3)2/PI) and ZnO nanoparticles, 2‐nm average primary size (ZnO/PI). This work shows how the origin of ZnO affects both the photoluminescence and thermal decomposition of the film. The presence of ZnO derived from Zn(NO3)2·6H2O was confirmed by X‐ray diffraction technique. The fluorescent intensities from Zn(NO3)2/PI and ZnO/PI were much higher than that from pure PI films. When the ZnO concentration exceeded a certain saturation level, the emission intensity decreased due to the undesirable aggregation of ZnO. At the same concentration, ZnO/PI exhibited higher emission intensity than Zn(NO3)2/PI. All samples prepared under nitrogen emitted higher intensity than their counterparts prepared under argon. The ZnO/PI film was thermally more stable than the Zn(NO3)2/PI one. From TEM images of 117.6 mol% ZnO/PI films, the ZnO aggregates, whose average size was 17–90 nm, were well distributed throughout the film but poorly dispersed in nanometer range. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2008
Eigenfactor: Does the principle of repeated improvement result in better estimates than raw citation counts?
Authors: Davis Philip M. 
Published: August 2008

AbstractEigenfactor.org, a journal evaluation tool that uses an iterative algorithm to weight citations (similar to the PageRank algorithm used for Google), has been proposed as a more valid method for calculating the impact of journals. The purpose of this brief communication is to investigate whether the principle of repeated improvement provides different rankings of journals than does a simple unweighted citation count (the method used by the Institute for Scientific Information@ [ISI]).
The presence of rRNA sequences in polyadenylated RNA and its potential functions
Authors: Kong Qiongman , Stockinger Michael P. , Chang Yueming , Tashiro Hirofumi , Lin Chien‐liang Glenn 
Published: August 2008

AbstractAccumulating evidence has shown that various lengths of ribosomal RNA (rRNA) sequences are widely present in polyadenylated RNA. This review article will discuss these polyadenylated rRNAcontaining transcripts (PART). PART are highly abundant and widely expressed in various tissues. It appears that there may be two types of PART. One type, type I, contains the rRNA segments (from ∼10 nucleotides up to several hundred nucleotides) located within the transcripts. It has been demonstrated that short rRNA sequences within type I PART may function as cis‐regulatory elements that regulate translational efficiency. The other type, type II, contains large portions or almost entire sequences of rRNA with a cap at the 5' end and poly(A) at 3' end. Recent work has shown that some type II PART have functional significance for some neurodegenerative disease processes and may play an important role in the pathogenesis of diseases. Further investigation in this area is critical to understanding the basic biology of PART and the potential role of PART in diseases.
Tools for the study of ribosome‐borne protein folding activity
Authors: Voisset Cécile , Thuret Jean‐Yves , Tribouillard‐Tanvier Déborah , Saupe Sven J. , Blondel Marc 
Published: August 2008

AbstractIn addition to its role in protein synthesis, which involves a peptidyl transferase activity, the ribosome has also been described to be able to assist protein folding, at least in vitro, as presented in a Research Highlight (Das, et al., Biotechnol. J. 2008). This in vitro‐described ribosome‐borne protein folding activity (RPFA) is yet poorly characterized in vivo, in part because of the lack of tools to study its biological significance. There is substantial evidence documenting RPFA in vitro, and an assay intended to detect this activity in vivo has been set up in bacteria, but this assay is indirect. In this review, we describe the different tools and tests currently available to study RPFA. We put a special emphasis on the various available inhibitors of this activity and in particular, we discuss the use of 6‐aminophenanthridine (6AP) and guanabenz (GA), two antiprion drugs that were very recently shown to specifically inhibit RPFA in vitro without any significant effect on the activity of the ribosome in protein synthesis. Therefore, these drugs should allow determining the potential biological role of RPFA. Importantly, the biological activity of 6AP and GA suggest a possible involvement of RPFA in human proteinopathies.
Adsorption of Atrazine and Simazine from Aqueous Solutions onto Poly(ε‐Caprolactone)
Authors: Ovez Bikem , Höll Wolfgang H. 
Published: August 2008

AbstractThe biodegradable synthetic polymer poly(ε‐caprolactone) was investigated as a substrate for denitrification. This substrate may also act as an adsorbent for two pesticides, i. e., atrazine and simazine, from water. The equilibrium was studied at 25, 35 and 45°C. The results were correlated using the Langmuir and Freundlich adsorption models. The total capacities of the adsorbent were defined from experimental data for atrazine (10.98 mg g–1) and simazine (27.54 mg g–1). The effect of temperature on the model constants and the thermodynamics of adsorption were investigated. The evaluation of the development of adsorption was achieved by assuming a pseudo‐second order chemical reaction.
A multidisciplinary approach to honest broker services for tissue banks and clinical data
Authors: Dhir Rajiv , Patel Ashok A. , Winters Sharon , Bisceglia Michelle , Swanson Dennis , Aamodt Roger , Becich Michael J. 
Published: August 2008

AbstractBACKGROUND.Honest broker services are essential for tissue‐ and data‐based research. The honest broker provides a firewall between clinical and research activities. Clinical information is stripped of Health Insurance Portability and Accountability Act‐denoted personal health identifiers. Research material may have linkage codes, precluding the identification of patients to researchers. The honest broker provides data derived from clinical and research sources. These data are for research use only, and there are rules in place that prohibit reidentification. Very rarely, the institutional review board (IRB) may allow recontact and develop a recontact plan with the honest broker. Certain databases are structured to serve a clinical and research function and incorporate ‘real‐time’ updating of information. This complex process needs resolution of a variety of issues regarding the precise role of the HB and their interaction with data. There also is an obvious need for software solutions to make the task of deidentification easier.METHODS.The University of Pittsburgh has implemented a novel, IRB‐approved mechanism to address honest broker functions to meet the specimen and data needs of researchers. The Tissue Bank stores biologic specimens. The Cancer Registry culls data and annotating information as part of state‐ and federal‐mandated functions and collects data on the clinical progression, treatment, and outcomes of cancer patients. The Cancer Registry also has additional IRB approval to collect data elements only for research purposes. The Clinical Outcomes Group is involved in patient safety and health services research. Radiation Oncology and Medical Oncology provide critical treatment related information. Pathology and Oncology Informatics have designed software tools for querying availability of specimens, extracting data, and deidentifying specimens and annotating data for clinical and translational research. These entities partnered and submitted a joint IRB proposal to create an institutional honest broker facility. The employees of this conglomerate have honest broker agreements with the University of Pittsburgh and the Medical Center. This provides a large group of honest brokers, ensuring availability for projects without any conflict of interest.RESULTS.The honest broker system has been an IRB‐approved institutional entity at the University of Pittsburgh since 2003. The honest broker system currently includes 33 certified honest brokers encompassing the multiple partners of this system. The honest broker system has handled >1600 requests over the past 4 years with a 25% increase in volume each year.CONCLUSIONS.The current results indicate that the collaborative honest broker model described herein is robust and provides a highly functional solution to the specimen and data needs for critical clinical and translational research activities. Cancer 2008. © 2008 American Cancer Society.
Fine needle biopsy and genetics, two allied weapons in the diagnosis, prognosis, and target therapeutics of solid pediatric tumors
Authors: Barroca Helena 
Published: August 2008

AbstractThe recognition that genetic defects identify some pediatric solid tumors and may represent prognostic markers has provided cytologists with an extra tool for dealing with such tumors. Using some entities as archetypes, we discuss the importance of the association of fine needle biopsy and genetics, in the diagnosis, prognosis, and therapy selection of solid pediatric tumors. Immunocytochemistry is important to differentiate neuroblastoma, PNET/Ewing sarcoma, alveolar rhabdomyosarcoma, lymphoma, and desmoplastic small round cell tumor. Despite its usefulness in many cases, it is not conclusive and some of the aforementioned tumors even share the expression of some antibodies. The detection of specific diagnostic translocations will thus provide additional information and allows a precise cytologic diagnosis. Kidney tumors are also frequent in children. Although no genetic abnormalities have been identified so far in nephroblastoma, other kidney tumors, such as mesoblastic nephroma, whose cytology pattern can masquerade nephroblastoma, are also characterized by specific translocations. Kidney tumors in children have also been associated recently with typical genetic alterations such as Xp11.2RCC. Concerning prognosis and therapy selection, neuroblastoma is a sort of paradigm. The identification of MYCN oncogene status as an independent prognostic factor is determinant, not only in the assessment of clinical evolution, but also in the identification of risk groups, and consequently in the appropriate therapy selection. Cytopathologists should be aware of the genetic alterations characterizing pediatric tumors in order to collect extra material to perform cytogenetics, FISH, PCR, and Southern blotting, to achieve the correct identification of such genetic changes. Diagn. Cytopathol. 2008;36:678–684. © 2008 Wiley‐Liss, Inc.
Myxoid liposarcoma of the breast in a 25‐year‐old female as a diagnostic pitfall in fine needle aspiration cytology: Report of a rare case
Authors: Pant Ishita , Kaur Gurjeet , Joshi Sanjeev Chandra , Khalid Imran Abdul 
Published: August 2008

AbstractPrimary sarcomas of the breast are extremely rare comprising less than 1.0% of all malignant tumors of the breast. It is even rarer to be reported in a 25‐year‐old female. This can cause a diagnostic dilemma not only for the clinician but also for the cytopathologist.A 25‐year‐old woman presented with a well defined firm, mobile lump in her right breast. With fine needle aspiration cytology (FNAC) and ultrasonography a diagnosis of fibroadenoma was made. The patient underwent lumpectomy. Histopathologically it was diagnosed as myxoid liposarcoma.This case is reported to highlight the fact that, even though rare in young females but the possibility of a breast lump being a myxoid liposarcoma does exist. This report discusses a primary myxoid liposarcoma of female breast, considers cytologic differential diagnoses with review of the relevant literature. Diagn. Cytopathol. 2008;36:674–677. © 2008 Wiley‐Liss, Inc.
H‐Bonded Porous Supramolecular Network of a CuII Complex Assisted by Assembled 2D Sheet of Chair Form Hexameric Water Cluster
Authors: Siddiqui Kafeel Ahmad , Mehrotra Gopal K. , Mrozinski Jerzy , Butcher Raymond J. 
Published: August 2008

AbstractThe supramolecular network of the complex having the formula [Cu(nicot)2·2NH3·2H2O]·6H2O 1 has been synthesized by transmetallation of the Zn–nicotinate complex by CuII ions and its crystallization in an ionic liquid. The supramolecular network of 1 shows unique H‐bonding in the sense that it not only participates in the formation of nanoporous 2D chains but also forms cyclic hexameric water cluster that adopt an ice‐like chair conformation, which together with octanuclear H‐bonded rings extend the network into a 3D open framework. X‐ray structural analysis, FTIR, thermal analysis, EPR and magnetic properties have been used to characterize this compound. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Heavier Group‐2‐Element Catalyzed Hydroamination of Carbodiimides
Authors: Lachs Jennifer R. , Barrett Anthony G. M. , Crimmin Mark R. , Kociok‐Köhn Gabriele , Hill Michael S. , Mahon Mary F. , Procopiou Panayiotis A. 
Published: August 2008

AbstractThe heteroleptic calcium amide [{ArNC(Me)CHC(Me)NAr}Ca{N(SiMe3)2}(THF)] (Ar = 2,6‐diisopropylphenyl) and the homoleptic heavier alkaline earth amides, [M{N(SiMe3)2}2(THF)2] (M = Ca, Sr and Ba) are reported as competent pre‐catalysts for the hydroamination of 1,3‐carbodiimides. Whilst the reaction scope is currently limited to reactions of aromatic amines with 1,3‐dialkylcarbodiimides, in most cases preparations in hydrocarbon solvents proceed rapidly at room temperature with catalyst loadings as low as 0.2 mol‐% and the guanidine reaction products crystallize directly from the reaction mixture. Initial studies are consistent with the intermediacy of heavier group‐2 guanidinate complexes.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Protection/Deprotection‐Free Syntheses and Structural Analysis of (Keto‐aryl)diynes
Authors: Osowska Karolina , Lis Tadeusz , Szafert Sławomir 
Published: August 2008

AbstractThe reactions of precursors 4‐BrC6H4COR with TMSC≡CH (Sonogashira coupling) followed by in situ deprotection and subsequent dimerization gave thermally stable dimeric keto‐diynes RCOC6H4(C≡C)2C6H4COR (8–11) as yellow powders in 25–85 % yields without the necessity of carbonyl group protection/deprotection steps. Compounds 8–11 were also synthesized by an alternative method that utilized α‐haloalkynes previously obtained directly from TMS‐protected 4‐RCOC6H4C≡CTMS alkynes. The resulting diynes were characterized by spectroscopic methods and in most cases by X‐ray crystallography. Careful analysis of the crystal data revealed a surprisingly high degree of chain curvature. Moreover, compounds 9 (R = Me) and 10 (R = Et) were extremely flat, which greatly facilitates electronic communication throughout the whole molecule. Deeper analysis of the packing motifs showed 9 to have a great potential for topochemical 1,4‐polymerization.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Electrocatalytic Determination of 6‐Tioguanine at a p‐Aminophenol Modified Carbon Paste Electrode
Authors: Mirmomtaz Elham , Asghar Ensafi Ali , Karimi‐Maleh Hassan 
Published: August 2008

AbstractA p‐aminophenol modified carbon paste electrode (p‐APMCPE) was constructed for determination of an anticancer drug 6‐thioguanine (6‐TG). The cyclic voltammogram showed that the electrocatalytic oxidation of 6‐TG at the surface of p‐APMCPE occurs at a potential about 840 mV less positive than at an unmodified electrode. Square‐wave voltammetry results presented that the electrocatalytic oxidation peak currents of 6‐TG in pH 9.0 had two linear dynamic ranges in the range of 0.2 to 8.0 and 8.0 to 350.0 μM 6‐TG with a detection limit of 0.08 μM. The kinetic parameters such as electron transfer coefficient (α) and rate constant were determined for the chemical reaction between 6‐TG and p‐aminophenol. Finally, this method was evaluated for the determination of 6‐TG in 6‐thioguanine tablets and urine samples.
PVC Supported Liquid Membrane and Carbon Paste Potentiometric Sensors Incorporating a Mn(III)‐Porphyrin for the Direct Determination of Undissociated Paracetamol
Authors: Saraswathyamma Beena , Pająk Marta , Radecki Jerzy , Maes Wouter , Dehaen Wim , Girish Kumar Krishnapillai , Radecka Hanna 
Published: August 2008

AbstractPVC supported liquid membrane and carbon paste potentiometric sensors incorporating an Mn(III)‐porphyrin complex as a neutral host molecule were developed for the determination of paracetamol. The measurements were carried out in solution at pH 5.5. Under such conditions paracetamol exists as a neutral molecule. The mechanism of molecular recognition between the Mn(III)‐porphyrin and paracetamol, leading to potentiometric signal generation, is discussed.
Electrochemically Active Mercury Nanodroplets Trapped in a Carbon Nanoparticle–Chitosan Matrix
Authors: Rassaei Liza , Sillanpää Mika , Edler Karen J. , Marken Frank 
Published: August 2008

AbstractA thin composite film of carbon nanoparticles (ca. 8 nm diameter) and chitosan biopolymer (poly‐D‐glucosamine, from chitin, 75–85% deacetylated) was prepared by evaporation from aqueous dispersion onto glassy carbon electrode surfaces. The amine groups in the chitosan biopolymer were used to effectively bind Hg(II) ions from an aqueous pH 5 KCl solution. During redox cycling voltammetric responses for bound mercury are readily observed and mercury nanodroplets (ca. 5.4 (±1.0) nm diameter based on SAXS measurements) are formed in the film by applying a negative potential. The binding of Hg(II) ions to the chitosan–carbon nanoparticle film occurs with an approximate Langmuirian constant of 2.7×104 mol−1dm3 and the process is dependent on (i) the chitosan content in the film, (ii) the Hg2+ concentration, and (iii) the immobilization time. The immobilized mercury nanodroplets within the carbon nanoparticle–chitosan film are electrochemically active and allow the co‐deposition of other metals in the form of amalgams. Preliminary experiments for the anodic stripping voltammetry for Pb2+ and for Cu2+ are demonstrated. Mercury nanodroplet modified chitosan–carbon nanoparticle film electrodes represent a novel electroanalytical tool.
An innovative methodology for seismic retrofitting of existing RC buildings by metal shear panels
Authors: De Matteis G. , Formisano A. , Mazzolani F. M. 
Published: August 2008

AbstractIn the present paper, the seismic upgrading of existing reinforced concrete (RC) structures by means of steel and pure aluminium shear panels is examined. After a preliminary experimental evaluation of the performance of the bare RC structure, a design approach based on the capacity spectrum method has been developed according to the procedure provided in the ATC 40 American guidelines. First, the geometrical configuration of the applied shear panels has been defined according to simplified analytical relationships, while appropriate steel members have been designed to allow the insertion of shear panels in the existing RC structure. Then, complex finite element models have been implemented in order to check the reliability of the proposed design procedure. Also, a numerical evaluation of the global response of the upgraded structure has been processed aiming at evaluating the interaction between the RC structure and the metal devices. Finally, the effectiveness of the applied shear panels has been proven by means of full‐scale experimental tests, which confirmed the significant improvement of the RC structure performance, in terms of strength, stiffness and deformation capacity. Copyright © 2008 John Wiley & Sons, Ltd.