bluuebunny/crossref_metadata_2025_split huggingface dataset:
The EASEMENT study: A multicentre, observational, cross‐sectional study to evaluate patient preferences, treatment satisfaction, quality of life, and healthcare resource use in patients with multiple myeloma receiving injectable‐containing or fully oral therapies
Authors: Ayto Robert , Annibali Ombretta , Biedermann Patricia , Roset Montserrat , Sánchez Emilio , Kotb Rami 
Published: February 2024

AbstractObjectiveAs multiple myeloma (MM) therapies advance, understanding patients', caregivers', and physicians' perspectives on, and satisfaction with, available treatment options and their impact on quality of life (QoL), is important.MethodsEASEMENT is a real‐world, observational, cross‐sectional study conducted in 19 sites within the UK, Canada, and Italy using retrospective chart reviews and surveys. Enrolled patients had clinical history available since diagnosis and had received ≥1 cycle of their current line of therapy. Primary objectives were to describe patient/caregiver QoL (EQ‐5D‐5L questionnaire), patient preference for oral/injectable therapies (single discrete‐choice question), and patient satisfaction (TSQM‐9 questionnaire).ResultsBetween October 2018 and March 2020, 399 patients were enrolled (n = 192 newly diagnosed multiple myeloma [NDMM], n = 206 relapsed/refractory multiple myeloma [RRMM], n = 1 missing). Among NDMM and RRMM patients, 78%/22% and 42%/58% were receiving injectables/orals, respectively. Both NDMM and RRMM patients significantly preferred orals versus injectables (p < .0001). No significant differences were reported in treatment satisfaction or QoL, but treatment convenience favoured orals over injectables with near significance (p = .053).ConclusionMM patients perceived greater convenience and preference for orals versus injectables. Oral treatments are useful for patients who cannot or prefer not to travel to clinics, or cannot perform self‐injection within the community.
Clinical implications of additional chromosomal abnormalities in adult acute myeloid leukemia with inv (16)/t(16;16)/CBFB::MYH11
Authors: Gao Juehua , Santana‐Santos Lucas , Fu Lucy , Alvey Emily , Chen Qing , Wolniak Kristy , Xia Zongjun , Aqil Barina , Behdad Amir , Ji Peng , Sukhanova Madina , Abaza Yasmin , Altman Jessica K. , Chen Yi‐Hua , Lu Xinyan 
Published: February 2024

AbstractObjectivesThis study assesses the clinical significance of additional cytogenetic abnormalities (ACAs) and/or the deletion of 3′CBFB (3′CBFBdel) resulting in unbalanced CBFB::MYH11 fusion in acute myeloid leukemia (AML) with inv (16)/t(16;16)/CBFB::MYH11.MethodsWe retrospectively evaluated the clinicopathologic features of 47 adult de novo AML with inv (16)/t(16;16)/CBFB::MYH11 fusion. There were 44 balanced and 3 unbalanced CBFB::MYH11 fusions. Given the low frequency of unbalanced cases, the latter group was combined with 19 published cases (N = 22) for statistic and meta‐analysis.ResultsBoth balanced and unbalanced cases were characterized by frequent ACAs (56.5% and 72.7%, respectively), with +8, +22, and del(7q) as the most frequent abnormalities. The unbalanced group tends to be younger individuals (p = .04) and is associated with a lower remission rate (p = .02), although the median overall survival (OS) was not statistically different (p = .2868). In the balanced group, “ACA” subgroup had higher mortality (p = .013) and shorter OS (p = .011), and patients with relapsed disease had a significantly shorter OS (p = .0011). Cox multivariate regression analysis confirmed that ACAs and history of disease relapse are independent risk factors, irrespective of disease relapse status. In the combined cohort, cases with ACAs had shorter OS than those with “Sole” abnormality (p = .0109).ConclusionsACAs are independent high‐risk factors in adult AML with inv (16)/t(16;16)/CBFB::MYH11 fusion and should be integrated for risk stratification in this disease. Larger studies are needed to assess the clinical significance of the unbalanced CBFB::MYH11 fusion resulting from the 3′CBFBdel.
Preoperative structural–functional coupling at the default mode network predicts surgical outcomes of temporal lobe epilepsy
Authors: Zhou Chunyao , Xie Fangfang , Wang Dongcui , Huang Xiaoting , Guo Danni , Du Yangsa , Xiao Ling , Liu Dingyang , Xiao Bo , Yang Zhiquan , Feng Li 
Published: February 2024

AbstractObjectiveStructural–functional coupling (SFC) has shown great promise in predicting postsurgical seizure recurrence in patients with temporal lobe epilepsy (TLE). In this study, we aimed to clarify the global alterations in SFC in TLE patients and predict their surgical outcomes using SFC features.MethodsThis study analyzed presurgical diffusion and functional magnetic resonance imaging data from 71 TLE patients and 48 healthy controls (HCs). TLE patients were categorized into seizure‐free (SF) and non‐seizure‐free (nSF) groups based on postsurgical recurrence. Individual functional connectivity (FC), structural connectivity (SC), and SFC were quantified at the regional and modular levels. The data were compared between the TLE and HC groups as well as among the TLE, SF, and nSF groups. The features of SFC, SC, and FC were categorized into three datasets: the modular SFC dataset, regional SFC dataset, and SC/FC dataset. Each dataset was independently integrated into a cross‐validated machine learning model to classify surgical outcomes.ResultsCompared with HCs, the visual and subcortical modules exhibited decoupling in TLE patients (p < .05). Multiple default mode network (DMN)‐related SFCs were significantly higher in the nSF group than in the SF group (p < .05). Models trained using the modular SFC dataset demonstrated the highest predictive performance. The final prediction model achieved an area under the receiver operating characteristic curve of .893 with an overall accuracy of .887.SignificancePresurgical hyper‐SFC in the DMN was strongly associated with postoperative seizure recurrence. Furthermore, our results introduce a novel SFC‐based machine learning model to precisely classify the surgical outcomes of TLE.
The distribution and mobility of academic talents in the Guangdong‐Hong Kong‐Macao Greater Bay Area
Authors: Lin Songyue , Liu Jin , Hu Ying 
Published: February 2024

AbstractThe Guangdong‐Hong Kong‐Macao Greater Bay Area is becoming a new world economic centre, but research on the law of academic talent mobility in the Greater Bay Area is still scarce at present. This study builds an overall analysis framework, introduces the curriculum vitae analysis method, and systematically collects resumes of academics from universities in Guangdong, Hong Kong, and Macao. Through this, we try to find the stock, distribution, study origin and inflow of academic talents in the Greater Bay Area, the internal mobility of academic talents in the Greater Bay Area, and the global mobility network of academic talents in the Greater Bay Area. Academic mobility is a significant topic in higher education research, closely related to higher education's competitiveness and attractiveness. This research is of positive significance for clarifying the basic situation of academic talents in the Greater Bay Area, scientifically carrying out talent planning during the new stage of China's national economic and social development, and scientifically attracting talents based on the law of talent mobility.
Caries indicators in relation to healthcare access and hygienic‐dietary habits in Spanish preschoolers
Authors: Prieto‐Regueiro Beatriz , Gómez‐Santos Gladys , Reichard‐Monefeldt Guillermo , Diéguez‐Pérez Montserrat 
Published: February 2024

AbstractIntroductionDental caries continues to be a public healthcare problem due to its high prevalence and morbidity. It was proposed to evaluate caries indicators in relation to healthcare access and hygienic‐dietary habits in Spanish preschoolers.Materials and MethodsA cross‐sectional study was carried out on a random sample consisting of 343 patients ranging from 3 to 5 years of age in the primary care setting, the main measurements were: dental care access, hygienic‐dietary habits, and caries registration according to WHO criteria.ResultsThe prevalence of caries was 35.3% and mean ± standard deviation (SD) dft was 1.51 ± 2.93. Preschoolers who had ever visited the dentist had a higher dft occurrence than those who had never attended the dentist. The lower prevalence of caries was significantly associated with the frequency of two daily brushings versus non‐daily brushing (p = 0.007; 25.3% vs. 47.1%) and was 10.7% lower in patients who had the habit of night brushing (p = 0.041). The consumption of sugary liquids between meals implied a higher dft index.ConclusionsThe high prevalence of early childhood caries and the dental care access associated with poor oral health suggest the need to implement a multidisciplinary oral healthcare program that involves both healthcare and dental healthcare professionals in Primary Health Care Units without forgetting the participation of the community and local administrations.
Network analysis of symptoms, physiological, psychological and environmental risk factors based on unpleasant symptom theory in patients with chronic heart failure
Authors: Wang Yaqi , Xu Xueying , Lv Qingyun , Zhao Yue , Zhang Xiaonan , Zang Xiaoying 
Published: February 2024

AbstractBackgroundSomatic symptoms and related factors in patients with chronic heart failure have been extensively researched. However, more insight into the complex interconnections among these constructs is needed, as most studies focus on them independently from each other.AimsThe aim of this study is to gain a comprehensive understanding of how somatic symptoms and related factors are interconnected among patients with chronic heart failure.MethodsA total of 379 patients were enrolled. Network analysis was used to explore the interconnections among the somatic symptoms and related risk factors.ResultsThe four core symptoms of chronic heart failure were daytime dyspnea, dyspnea when lying down, fatigue and difficulty sleeping. Within the network, the edge weights of depression–anxiety, subjective social support–objective social support, and subjective social support–social support availability were more significant than others. Among physiological, psychological and environmental factors, the edge weights of NYHA–dyspnea, depression–difficulty sleeping, and social support availability–dyspnea when lying down were more significant than others. Depression and anxiety had the highest centrality, indicating stronger and closer connections with other nodes.ConclusionsPsychological and environmental factors stood out in the network, suggesting the potential value of interventions targeting these factors to improve overall health.
Personalized pricing versus showrooming: competition between online and offline retailers
Authors: Ren Zhenzhen , Tian Junfeng , Kang Shurong , Tang Meixian , Tian Jinsong 
Published: February 2024

AbstractThis study examines how personalized pricing affects customers’ showrooming behavior in the duopoly competition with horizontal product differentiation between traditional and online retailers. For the available personalized pricing strategies, we obtained the optimal decisions for both retailers in the scenarios with and without showrooming. Our results indicate that adopting personalized pricing under particular conditions enables each retailer to be more profitable, even in the presence of showrooming purchases. This finding explains why an increasing number of online and offline retailers have implemented personalized pricing based on technical means and consumer purchase records. It is also demonstrated that personalized pricing can counter showrooming behavior of consumers amidst the competition between both retailers, which provides a novel theoretical basis for dealing with cross‐channel shopping in multichannel retail competition. We further clarify how retailers can avoid being trapped in a prisoner's dilemma when both sides have access to personalized pricing. Also, the adoption of personalized pricing can improve consumer surplus and social welfare.
Unique combination of hyaluronic acid and amino acids in the management of patients with a range of moderate‐to‐severe chronic wounds: Evidence from international clinical trials
Authors: Romanelli Marco 
Published: February 2024

AbstractChronic wounds present a prolonged burden to patients, their families and healthcare systems. There is evidence that the unique combination of hyaluronic acid (HA) and amino acids (Vulnamin®) promotes re‐epithelialization of wounds and stimulates activation and proliferation of fibroblasts with a significant increase in the regeneration of epithelial cells. Tissue regeneration and tissue repair are considered to be the fundamental activities of this unique combination of HA and amino acids that distinguishes it from other wound healing products. A review of trials over the last 15 years indicates distinct advantages of the unique combination of HA and amino acids, in terms of healing rate and induction of granulation tissue production compared with HA alone.
The role of ecological niche conservatism in the evolution of bird distributional patterns in Mesoamerican seasonally dry forests
Authors: Chan Pak Tsun , Arroyo‐Cabrales Joaquín , Prieto‐Torres David A. , Sánchez‐González Luis A. 
Published: February 2024

AbstractAimDue to its complex biogeographical and ecological history, the seasonally dry forests (SDF) of Mesoamerica are considered a biodiversity hotspot. SDF are currently distributed in relatively large and continuous, but isolated areas, in which there are both high total and endemic species numbers. Among birds, few species are shared across SDF patches; other species are endemic to one of these; and for two species currently endemic to one patch, fossils have been recovered in a different one, suggesting a former widespread distribution in so species, implying that current distributional patterns are probably recent.LocationMesoamerican seasonally dry forests.MethodsWe assessed the role of niche divergence/conservatism in the evolution of bird distributional patterns. Using an ecological niche modelling approach, we estimated palaeodistributions for two species currently endemic to the SDF of Yucatan Peninsula (YP), two to the Mesoamerican Pacific Slope (MPS) with fossil record in the YP and two more showing an allopatric pattern. For comparison, we simulated virtual species (VS) matching each pattern, assuming they represent the expected distribution of species in each SDF patch. To test hypothesis of niche conservatism, we assessed the niche equivalence/similarity between the patches represented by the VS, and in each bird species and its VS distributional counterpart.ResultsOur results showed three patterns: (i) no past geographical connectiveness among suitable areas; (ii) niche conservatism, but not equivalence, despite low niche overlap and geographical distance; and (iii) potential niche divergence.Main ConclusionsFor birds currently endemic to the MPS, our results suggest that the absence from the YP may be attributed to the loss of their environmental niche. Widespread species showed either niche conservatism or divergence. YP endemics showed niche divergence. Our results underline the role of niche divergence/conservatism in the evolution of distributional patterns in Mesoamerican SDF avifauna.
An exploration of gendered differences in cognitive, motivational and emotional aspects of game‐based math learning
Authors: Zhang Lu , Lei Yue , Pelton Tim , Pelton Leslee Francis , Shang Junjie 
Published: February 2024

AbstractBackgroundDigital game‐based learning (DGBL) has the potential to provide a gender inclusive learning environment for children.ObjectiveThe present study aimed to explore gendered differences among primary school learners in grades three, four, and five within the context of game‐based fraction learning from cognitive, motivational and emotional perspectives.MethodsTwo hundred and sixty‐nine participants completed a pre‐test and post‐test on fraction conceptual knowledge and surveys in math anxiety, intrinsic motivation and self‐efficacy. In addition, facial expression detection technology was employed to evaluate emotional states.ResultsIn general, within the DGBL environment, boys and girls exhibited similar performance in both their understanding of fraction concepts and their motivational aspects. However, gender differences were identified and manifested uniquely across different grade levels. Specifically, third‐grade girls exhibited significantly lower self‐efficacy than boys, but after DGBL intervention, the gender gap in self‐efficacy was no longer significant. Additionally, third‐grade girls achieved significant improvements in both the competence and interest dimensions of their intrinsic motivation, while boys did not show significant improvements. In the fourth grade, girls exhibited a significantly higher frequency of angry expressions compared to boys during gameplay. Fifth‐grade girls' cognitive performance appeared to be less correlated with motivational factors compared to boys.ConclusionsThe results suggest that DGBL may help narrow the gender difference in math learning, with girls potentially benefiting more from DGBL than boys.
The Ideational Power of Strategic Autonomy in EU Security and External Economic Policies
Authors: Juncos Ana E. , Vanhoonacker Sophie 
Published: February 2024

AbstractThis article undertakes a comparative analysis of European Union security and external economic policies to explore the different trajectories of strategic autonomy (SA) in these two domains. In so doing, it contributes to a better understanding of endogenous drivers of policy change in response to geopoliticising pressures. Drawing on discursive institutionalism, it analyses three dimensions of ideational power: power in, power through and power over. The evidence, based on documentary analysis and interviews, demonstrates that though SA presented a more significant challenge to pre‐established paradigms in external economic relations, the role of the Commission as an ideational entrepreneur, supported by its coercive power, facilitated the adoption of the idea of (open) SA. Conversely, French President Emmanuel Macron was unable to persuade others of the adoption of a sovereigntist conception of SA in security, with the exception of defence industrial policy, where the Commission enjoys budgetary power and competences.
Recent developments in tomato drying techniques: A comprehensive review
Authors: Pravitha M. , Dipika Agrahar Murugkar , Ajesh Kumar V. 
Published: February 2024

AbstractTomatoes, a highly perishable agricultural product, are commonly dried to extend their shelf life. They serve as raw materials in various domains, including direct consumption and as key ingredients in processed foods, functional foods, and nutraceuticals. However, producing dried tomato products with quality attributes equivalent to fresh tomatoes, such as nutrient content, appearance, flavor, texture, and reconstitution properties, poses significant challenges. Several research attempts have been made to evaluate the feasibility of different drying methods for tomatoes. Solar drying, hot air drying, and spray drying are commonly employed techniques, each with its own set of advantages and disadvantages. Conventional solar drying practices often result in extended drying times and undesirable quality parameters. Hence, it is imperative to adopt enhanced solar drying techniques for the large‐scale production of dried tomato products. Additionally, hybrid‐drying approaches can be explored to achieve better quality products with reduced drying times. Pretreatments before drying can also enhance overall drying performance. Combining conventional drying with novel drying methods, precise selection of drying parameters and pretreatments are demonstrated as efficient ways to improve the drying rate while preserving food quality. Modeling the drying process is also critical for designing large‐scale dryers, selecting appropriate drying conditions, maintaining product quality, and process optimization. Therefore, this article aims to provide detailed insight into existing drying methods with their unique features and modeling approaches, which may enable professionals and scientists to choose better and optimized tomato drying method to deliver the highest quality product to consumers.Practical ApplicationsProcessing tomatoes as dried products is a potential area to explore to minimize their postharvest loss. Lack of awareness regarding how to process, what parameters to consider, and which method to employ are hurdles in adopting and popularizing dried tomato products. Hence, it is crucial to consolidate the key findings pertaining to tomato drying from various methods into a unified platform. This will provide valuable guidance to future researchers and enable consumers to make informed decisions when selecting the most suitable drying method. Therefore, this comprehensive review aims to elucidate the current practices in tomato drying, highlighting their potential benefits and limitations.
Psychosocial stressors associated with frailty in community‐dwelling older adults in the United States
Authors: Shakya Shamatree , Silva Susan G. , McConnell Eleanor S. , McLaughlin Sara J. , Cary Michael P. 
Published: February 2024

AbstractBackgroundFrailty is multifactorial; however, psychosocial stressors contributing to frailty are poorly understood. This study aimed to examine whether gender, race/ ethnicity, and education are associated with differential exposure to psychosocial stressors, determine psychosocial stressors contributing to frailty, and explore the mediating psychosocial stressors pathway.MethodsThis cross‐sectional study involved 7679 community‐dwelling older adults (≥65) from the Health and Retirement Study (2006 and 2008 waves). Psychosocial stressors such as loneliness, low subjective social status, financial strain, poor neighborhood cohesion, everyday discrimination, and traumatic life events were measured. Frailty was defined by the Fried phenotype measure. Multivariable logistic regressions were used to examine the association of gender, race/ethnicity, and education with psychosocial stressors, psychosocial stressors associated with frailty, and the mediating psychosocial stressors pathway.ResultsFemales experienced greater financial strain but lower discrimination (both p < 0.05). Older adults who identified as Hispanic, Black, and racially or ethnically minoritized experienced low subjective social status, high financial strain, low neighborhood cohesion, and high discrimination than their White counterparts (all p < 0.05). Those with lower education experienced high loneliness, low subjective social status, high financial strain, low neighborhood cohesion but lower traumatic life events (all p < 0.05). Psychosocial stressors: High loneliness, low subjective social status, high financial strain, and low neighborhood cohesion (all p < 0.05) independently increased the odds of frailty. The mediating pathway of psychosocial stressors was not significant. ConclusionDisparities exist in exposure to psychosocial stressors associated with frailty. Multilevel interventions are needed to reduce the influence of psychosocial stressors on frailty.