bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nationwide study of the outcome of popliteal artery aneurysms treated surgically
Authors: Ravn H , Bergqvist D , Björck M 
Published: May 2007

Abstract

Background
The aim was to study the epidemiology and outcomes of popliteal artery aneurysm (PA) treated surgically.

Methods
Among 110 000 procedures registered prospectively in the Swedish Vascular Registry (Swedvasc), there were 717 primary operations for PA among 571 patients. Patient records were reviewed and data validated against other registries.

Results
The median age of the patients was 71 years; 5·8 per cent were women. Among 264 legs treated urgently, 235 had acute ischemia and 24 had rupture. Of patients with unilateral PA, 28·1 per cent had an aortic aneurysm, 8·4 per cent an iliac aneurysm and 9·4 per cent a femoral aneurysm. Extra-popliteal aneurysms were more common when the PAs were bilateral (P = 0·004). The rate of limb loss within 1 year of operation was 8·8 per cent; 12·0 per cent for symptomatic and 1·8 per cent for asymptomatic limbs (P &lt; 0·001). Risk factors for amputation were symptomatic disease, poor run-off, urgent treatment, age over 70 years, prosthetic graft and no preoperative thrombolysis when the ischaemia was acute. Amputation rates decreased over time (P = 0·003). Crude survival was 91·4 per cent at 1 year and 70·0 per cent at 5 years.

Conclusion
Multiple aneurysm disease was common when PAs were bilateral. Preoperative thrombolysis of acute thrombosis and the use of vein grafts for bypass improved outcome.
Evaluation of various POSSUM models for predicting mortality in patients undergoing elective oesophagectomy for carcinoma
Authors: Lai F , Kwan T L , Yuen W C , Wai A , Siu Y C , Shung E 
Published: May 2007

Abstract

Background
The aim of the study was to validate the use of the Physiological and Operative Severity Score for the enUmeration of Mortality and morbidity (POSSUM), Portsmouth (P) POSSUM and upper gastrointestinal (O) POSSUM models in patients undergoing elective thoracic oesophagectomy for carcinoma.

Methods
The observed in-hospital mortality rates in 545 patients undergoing elective thoracic oesophagectomy for squamous cell carcinoma of the oesophagus in all public hospitals in Hong Kong was compared with rates predicted by POSSUM, P-POSSUM and O-POSSUM. The discriminatory power of these models was assessed using receiver–operator characteristic (ROC) curve analysis.

Results
The observed mortality rate was 5·5 per cent, whereas rates predicted by POSSUM, P-POSSUM and O-POSSUM were 15·0, 4·7 and 10·9 per cent respectively. P-POSSUM showed no lack of fit (P = 0·814), but POSSUM (P &lt; 0·001) and O-POSSUM (P = 0·002) showed lack of fit against observed mortality. POSSUM overpredicted mortality across nearly all risk groups, whereas O-POSSUM overpredicted mortality in patients with low physiological scores and in older patients. POSSUM (area under ROC curve 0·776) and P-POSSUM (0·776) showed equally good discriminatory power but O-POSSUM (0·676) was inferior.

Conclusion
P-POSSUM provided the most accurate prediction of in-hospital mortality in this group of patients who had elective oesophagectomy.
Über Pteridine, V. Mitteil.: Die Konstitution des Ichthyopterins
Authors: Tschesche Rudolf , Korte Friedhelm 
Published: May 2007

AbstractEs wurde papierchromatographisch erkannt, daß das von R. Hüttel und G. Sprengling beschriebene Ichthyopterin aus den Häuten von Cypriniden des Bodensees nicht vollkommen einheitlich ist. Die Hauptkomponente ist die 6.9‐Dioxy‐2‐amino‐pteridyl‐(8)‐essigsäure; sie wurde synthetisch bereitet und stimmt in allen Eigenschaften mit dem Naturprodukt überein, soweit ein Vergleich bei den vorliegenden geringen Mengen des letztgenannten möglich war.
Über Verbindungen mit Urotropin‐Struktur, III. Mitteil.: Darstellung des Ringsystems des 2.4.9‐Trioxa‐adamantans
Authors: Stetter Hermann , Dohr Manfred 
Published: May 2007

AbstractTriallyl‐ und Trimethallyl‐carbinol wurden durch Umsetzung von Chlorameisensäureester mit Allyl‐ und Methallyl‐magnesiumchlorid dargestellt. Durch Ozonisation des Triallyl‐carbinols und reduzierende Spaltung des Triozonids in Alkohol wurde das Hexaacetal des Oxymethan‐triacetaldehyds erhalten. Die Verseifung des Acetals ergab 7‐Oxy‐2.4.9.‐trioxa‐adamantan. In ähnlicher Weise konnte durch Ozonolyse des Trimethallylcarbinols 7‐Oxy‐1.3.5‐trimethyl‐2.4.9‐trioxa‐adamantan erhalten werden.
Synthese des 3′.8‐Dimethyl‐1.2‐cyclopenteno‐phenanthrens
Authors: Woodward Robert Burns , Inhoffen Hans Herloff , Larson Harold O. , Menzel Karl‐Heinz 
Published: May 2007

AbstractDie Totalsynthese des 3′.8‐Dimethyl‐1.2‐cyclopenteno‐phenanthrens wird beschrieben und seine Identität mit dem Kohlenwasserstoff C19H18 sichergestellt, der aus Sterinphenol durch Selendehydrierung gewonnen wurde.
Synthesen nichtreduzierender Disaccharide
Authors: Bredereck Hellmut , Höschele Günther , Ruck Klaus 
Published: May 2007

AbstractBei der thermischen Kondensation von Tetraacetyl‐monosen mit freiem Lactolhydroxyl i. Ggw. von sauren Kondensationsmitteln entstehen nebeneinander die Oktaacetate der drei nichtreduzierenden Disaccharide mit α.α‐, α.β‐ und β.β‐Verknüpfung. Es ist auf diese Weise möglich, Disaccharide mit α.α‐Konfiguration darzustellen, wie durch die Synthese der α.α‐Galaktobiose gezeigt wird. Es wird ferner die Synthese von β.β‐Galaktobiose sowie eine modifizierte Darstellung von Isosaccharose‐oktaacetat beschrieben.
Die Enol‐Enolat‐Gleichgewichte und die Enol‐Methyläther einiger „trans‐fixierter”︁ β‐Diketone)
Authors: Eistert Bernd , Reiss Werner 
Published: May 2007

AbstractVon einigen Cyclobutan‐, Cyclopentan‐ und Cyclohexan‐1.3‐dionen werden die UV‐Spektren der undissoziierten Enol‐Formen, der Enolat‐Anionen und der Enol‐Methyläther gemessen und diskutiert. Die Enol‐Formen dieser „trans‐fixierten”︁ β‐Diketone sind, da sie nicht chelatisiert sein können, relativ stark sauer (PKs = etwa 2.8 bis 5.5). Die Dissoziationskonstanten der Enole werden aus den bei verschiedenen pH‐Werten gemessenen UV‐Spektren berechnet. Das Enol‐Enolat‐Gleichgewicht ist bei vielen trans‐fixierten Enolen im Bereich der bei UV‐Messungen benützten Konzentrationen konzentrationsabhängig.
Synthesen mit α‐Chloräthylschwefelchlorid (VII. Mitteil. über organische Schwefelchloride)
Authors: Brintzinger Herbert , Ellwanger Hans 
Published: May 2007

AbstractEs wird über die Darstellung von α‐Chlor‐äthylschwefelchlorid sowie über die mannigfaltigen, mit dieser Verbindung durchführbaren Synthesen, die u.a. auch zur Bildung von Makromolekülen durch Polykondensation und Polymerisation führen, berichtet.
Notiz über die Ozonisierung von 1.2‐Diphenyl‐inden
Authors: Bailey Philip S. 
Published: May 2007

AbstractDie Literaturangabe, nach der 1.2‐Diphenyl‐inden bei der Ozonisierung in anomaler Reaktion o‐Benzoyl‐benzoin liefert, hat sich als irrtümlich erwiesen; es bildet vielmehr das normale Ozonid.
Beitrag zur Kenntnis der cyclischen Acetale des Glyoxals
Authors: Faass Ursula , Hilgert Horst 
Published: May 2007

AbstractDie zwei bisher fälschlich als cis‐ und trans‐Naphthodioxan bezeichneten und bei Synthesen stets als Gemisch anfallenden isomeren Glyoxal‐bisäthylenacetale konnten auf getrennten Wegen erhalten werden. Auf Grund ihrer Bildung aus 2.3‐Dichlor‐1.4‐dioxan kommt der seither als trans‐Naphthodioxan angesehenen Verbindung vom Schmp. 136° tatsächlich die Konstitution eines Naphthodioxans zu. Die Verbindung vom Schmp. 111–112°, die auch über das Äthylenmonoacetal des Glyoxals dargestellt werden konnte, ist in Wirklichkeit Bis‐2.2'‐[1.3‐dioxolan].
Über die Synthese des 10.11‐Dimethyl‐1.2‐benzazulens und des 2.7‐Dimethyl‐[indeno‐1′.2′:9.10‐phenanthrens]
Authors: Ziegenbein Willi 
Published: May 2007

AbstractDurch Ringerweiterungsreaktion konnte aus 2.3‐Dimethyl‐fluoren und Diazoessigester nach Verseifung und anschließender spontaner Dehydrierung ein Dimethyl‐1.2‐benzazulen erhalten werden. Der oxydative Abbau mit Kaliumpermanganat ergab Pyromellitsäure bzw. deren Dianhydrid, so daß auf die Struktur des 10.11‐Dimethyl‐1.2‐benzazulens geschlossen werden kann.Die Synthese des 2.7‐Dimethyl‐[indeno‐1′.2′:9.10‐phenanthrens] wird mitgeteilt.
Photoelektrische Registrierung der Raman‐Spektren farbiger Substanzen mit He‐Ne‐6328 Å‐Laser‐Erregung
Authors: Brandmüller Josef , Hacker Herbert , Schrötter Heinz W. 
Published: May 2007

AbstractDie Vorteile der Erregung von Raman‐Spektren mittels He‐Ne‐6328 Å‐Laser für Flüssigkeiten und Kristallpulver mit einer Absorption bis ca. 5800 Å und die damit verbundene Erweiterung des Anwendungsbereiches der Raman‐Spektroskopie werden gezeigt. Die dabei erforderlichen geringen Substanzmengen und einfachen Probenanordnungen werden anhand der photoelektrisch registrierten Spektren demonstriert.
Monovalent Ion Dependence of Neomycin B Binding to an RNA Aptamer Characterized by Spectroscopic Methods
Authors: Stampfl Sabine , Lempradl Adelheid , Koehler Gottfried , Schroeder Renée 
Published: May 2007

AbstractUnderstanding the interactions of small molecules like antibiotics with RNA is a prerequisite for the development of novel drugs. In this study we address structural and thermodynamic features of such interactions by using a simple model system: the binding of the highly charged antibiotic neomycin B to a short hairpin RNA molecule. Nucleotide A16, which acts as a flap over the neomycin B binding pocket, was substituted by the fluorescent adenine analogue 2‐aminopurine (2‐AP). Steady‐state and time‐resolved fluorescence measurements were complemented by UV‐melting and circular dichroism studies. The binding of neomycin B at three sites was found to have a strong inverse correlation with Na+ concentration. For the highest‐affinity site, both fluorescence and UV absorption experiments were consistent with a model assuming at least three neomycin NH3+ groups participating in addition to hydrogen bonds in electrostatic interactions with the RNA. The variation of fluorescence intensity and lifetime upon neomycin B binding indicated unstacking of 2‐AP16 from neighbouring bases as it flipped over the binding pocket. RNA conformational changes upon binding of the antibiotic were confirmed by circular dichroism. The two weaker binding sites were characterized as unspecific binding to the aptamer, while the high‐affinity binding event was shown to be highly specific even at high ionic concentration. In addition, 2‐AP was confirmed to be a noninvasive fluorescent probe; it serves as a sensitive spectroscopic tool to investigate details of the interactions between small molecules and RNA.
New approach to septal ablation: Glue (cyanoacrylate) septal ablation
Authors: Oto Ali , Aytemir Kudret , Deniz Ali 
Published: May 2007

AbstractAlcohol septal ablation is an alternative way of treatment in hypertrophic obstructive cardiomyopathy patients who are refractory to medical treatment. This case report describes a new way of septal ablation with glue (cyanoacrylate) in a HOCM patient who has extensive collateral to posterior descending coronary artery which precludes alcohol ablation. © 2007 Wiley‐Liss, Inc.
Factors affecting long‐term survival following renal artery stenting
Authors: Bates Mark C. , Campbell John E. , Stone Patrick A. , Jaff Michael R. , Broce Mike , Lavigne, Philip S. 
Published: May 2007

AbstractIntroduction: This study defines clinical variables at the time of renal artery stenting that may be predictors of long‐term all‐cause mortality. Methods: The data are derived from the single operator, single center, renal stent retrospective study (SOCRATES) and includes a review of 748 (336 men, 412 women) consecutive symptomatic patients with de novo atherosclerotic renal artery stenosis treated over an 11‐year period. All patients had clinical indications for renal revascularization, including, but not limited to; suboptimal control of hypertension, chronic kidney disease, and cardiac disturbance syndromes. Clinical variables at the time of the index procedure were evaluated as predictors of all‐cause mortality using multivariate analysis. Mortality data were derived from hospital records and formal queries of the State Department of Health and Human Services, Health and Vital Statistics Division database. Results: In‐hospital, 30‐day and 6‐month mortality rates were 0.5, 2.0, and 6.3%, respectively. Overall patient survival at years 1, 5, and 10 was 91.2, 66.6, and 40.9%, respectively. Comorbid conditions, including chronic obstructive pulmonary disease and congestive heart failure, were independently associated with increased mortality. There were incremental changes in mortality in patients with baseline azotemia, [preprocedure serum creatinine (sCr) 1.5–2.09 mg/dL hazard ratio 1.52; sCr >2.5 mg/dL hazard ratio 3.39]. Therapy with lipid lowering agents offered a survival advantage (hazard ratio 0.69, P = 0.0.049); however, this study was not designed to evaluate a “protective effect” of lipid lowering medications. Conclusions: Patients with chronic obstructive pulmonary disease and congestive heart failure undergoing renal artery stent revascularization have a poor long‐term prognosis. Baseline azotemia is the strongest independent predictor of all cause mortality, with more than 70% of patients with marked azotemia (sCr >2.5) dead at 5 years. © 2007 Wiley‐Liss, Inc.
New distal embolic protection device the FiberNet® 3 dimensional filter: First carotid human study
Authors: Henry Michel , Polydorou Antonios , Henry Isabelle , Liasis Nikos , Polydorou Adamantia , Polydorou Victoria , Demesticha Theano , Skandalakis Panayiotis , Kotsiomitis Evaggelos , Hugel Michel , Sedgewick Jerry , Ruth George 
Published: May 2007

AbstractObjective: Evaluate the performance and safety of the FiberNet® Embolic Protection System during carotid artery intervention. Background: Carotid Angioplasty and Stenting (CAS) can be proposed to treat the majority of carotid stenoses. Brain embolization takes place and routine use of Embolic Protection Devices (EPD) is warranted. Many EPDs have significant limitations, which may be addressed by a new EPD, the FiberNet® (Lumen Biomedical, Plymouth, MN). Methods: The system consists of a 3‐dimensional expandable filter made of fibers, which expand radially, mounted onto a 0.014″ wire and retrieval catheter. FiberNet can capture particles as small as 40 μm without compromising flow. Results: 35 lesions treated in 34 patients. Male 67.6%. Age: 71.4 ± 8.8 (50–85). Average stenosis 84.5% ± 7.9 (70–99). 29.4% were symptomatic. Technical success: 34/35 (97%). No stroke or death within 30 days. Neurological events: two permanent amaurosis, one amaurosis fugax. All samples visually contained significant amounts of emboli. The mean surface area of debris caught was 63.8 mm2 (37.7–107.5). Comparisons were made with other EPDs. The mean surface area of debris caught was 12.2 mm2 (2.7–34.3). No changes were noted in CT/MRI at 30‐day post procedure. Conclusion: The first human use of this new novel EPD in carotid artery stenting is encouraging. The FiberNet was easy to use and confirmed the ability to capture particles less than 100 μm. The feasibility of the FiberNet has been demonstrated. Additional patients will demonstrate the overall safety and efficacy of this new EPD device. © 2007 Wiley‐Liss, Inc.
Alcohol septal ablation after failed surgical myectomy
Authors: Joyal Dominique , Arab Dinesh , Chen‐Johnston Carol , Leya Ferdinand 
Published: May 2007

AbstractWe describe the case of a successful alcohol septal ablation in a patient with persistent gradient and severe symptoms postsurgical myectomy. The alcohol ablation of the thickened septum abolished the left ventricular outflow gradient and the systolic anterior motion (SAM) of the mitral valve. Although the surgical literature advocates for mitral valve replacement in patients who continue to have SAM with significant outflow obstruction postmyectomy, targeted alcohol septal ablation of the remaining septum appears to be an attractive alternative. © 2007 Wiley‐Liss, Inc.
Overview of the 2006 Food and Drug Administration Circulatory System Devices Panel meeting on drug‐eluting stent thrombosis
Authors: Pinto Slottow Tina L. , Waksman Ron 
Published: May 2007

AbstractDrug‐eluting stents (DES) seemed likely to mitigate the problem of restenosis and have become the predominant stent deployed during percutaneous coronary intervention (PCI). Sustained concerns about the rate of stent thrombosis (ST), particularly very late ST (>1 year following PCI) led to a meeting of the Circulatory System Devices Advisory Panel to address “on‐label” and “off‐label” use as well as appropriate duration of dual antiplatelet therapy following DES. Over 40 presentations by members of the FDA, industry personnel, and leaders in the field of interventional cardiology helped set forth the body of data available on DES. Standardized definitions of ST created by the Academic Research Consortium were applied to existing randomized trials and registries. At the end of the 2‐day session, the consensus of the panel was that “on‐label” DES use is not associated with increased incidence of death and myocardial infarction (MI), although it is associated with increased rates of very late ST. “Off‐label” use is associated with increased risk of death or MI when compared with “on‐label” use. Insufficient data exist to determine the duration of clopidogrel that would minimize ST and bleeding risk, but the panel agreed with the current ACC/AHA/SCAI guidelines regarding dual antiplatelet therapy for at least 12 months in patients at low risk for bleeding, especially with “off‐label” use. More data from trials designed with better control arms and prespecified analyses of complex patients and lesions subsets over longer periods of follow‐up are needed. © 2007 Wiley‐Liss, Inc.
Percutaneous mitral valve annuloplasty for ischemic mitral regurgitation: First in man experience with a temporary implant
Authors: Dubreuil Olivier , Basmadjian Arsène , Ducharme Anique , Thibault Bernard , Crepeau Jacques , Lam Jules Y.T. , Bilodeau Luc 
Published: May 2007

AbstractObjective: This study evaluated human feasibility and acute efficacy of a novel percutaneous transvenous mitral annuloplasty (PTMA™) device (Viacor) placed temporarily in the coronary sinus (CS): the implant allows in‐situ incremental adjustment to optimally reduce the anterior–posterior mitral annulus (MA) dimension, and improve leaflet co‐aptation and reducing mitral regurgitation (MR). Background: Surgical annuloplasty remains the standard treatment of severe ischemic MR but its application is limited by high morbidity and mortality. The effectiveness of PTMA device (Viacor) to reduce MR in the short‐term has been demonstrated in animals studies but not in humans. Methods: Symptomatic patients with ischemic MR graded 2+ to 4+ requiring surgical mitral annuloplasty were screened. Patients with any mitral leaflet or mitral apparatus abnormality were excluded. Preoperatively, under general anesthesia and transesophageal echocardiography guidance, a temporary PTMA device was placed via the right internal jugular or subclavian vein. Results: Four patients were studied. After device placement and adjustment, regurgitant volume was substantially reduced (45.5 ± 24.4 to 13.3 ± 7.3 ml) via MA anterior–posterior diameter reduction (40.75 ± 4.3 to 35.2 ± 1.6 mm) in 3 patients. In one patient, the PTMA device could not be deployed due to extreme angulated anatomy. Conclusions: PTMA in human is feasible and reduces ischemic MR (to grade 1+) by reducing MA anterior–posterior diameter. Temporary placement of the PTMA device may assist in the development of permanent implants and ensure optimal efficacy. © 2007 Wiley‐Liss, Inc.
Porphyrin, Phthalocyanine and Porphyrazine Derivatives with Multifluorenyl Substituents as Efficient Deep‐Red Emitters
Authors: Barker Carl A. , Zeng Xianshun , Bettington Sylvia , Batsanov Andrei S. , Bryce Martin R. , Beeby Andrew 
Published: May 2007

AbstractThe synthesis and photophysical properties are described for a series of porphyrin, phthalocyanine and pyrazinoporphyrazine derivatives which bear four or eight peripheral fluorenyl substituents as antennae. Representative examples are 5,10,15,20‐tetra(9,9‐dihexyl‐9H‐fluoren‐2‐yl)porphyrin (2), 5,10,15,20‐tetrakis[4‐(9,9‐dihexyl‐9H‐fluoren‐2‐yl)phenyl]porphyrin (3), 2,3,9,10,16,17,23,24‐octakis(9,9‐dihexyl‐9H‐fluoren‐2‐yl)‐29H,31H‐phthalocyanine (8) and 2,3,9,10,16,17,23,24‐octakis[4‐(9,9‐dihexyl‐9H‐fluoren‐2‐yl)phenyl]‐29H,31H‐tetrapyrazinoporphyrazine (9). Palladium‐mediated Suzuki–Miyaura cross‐coupling reactions have been key steps for attaching the substituents. The compounds are deep‐red emitters: λmax(em)=659 (3), 737 (8) and 684 nm (9). Their absorption and emission spectra, their fluorescence lifetimes and quantum yields are correlated with the structures of the macrocycles and the substituents. The solution fluorescence quantum yields of porphyrin derivatives substituted with fluorene (2–4) and terphenyl substituents (7) (Φf=0.21–0.23) are approximately twice that of tetraphenylporphyrin. For phthalocyanine derivative 8, Φf was very high (0.88). Specific excitation of the fluorene units of 8 produced emission from both of them (λmax=480 nm) and also from the phthalocyanine core (λmax=750 nm), indicating a competitive rate of energy transfer and radiative decay of the fluorenes. Organic light‐emitting devices (OLEDs) were made by spin‐coating techniques by using a polyspirobifluorene (PSBF) copolymer as the host blended with 3 (5 wt. %) in the configuration ITO/PEDOT:PSS/PSBF copolymer:3/Ca/Al. Deep‐red emission (λmax=663 nm; CIE coordinates x=0.70, y=0.27) was observed with an external quantum efficiency of 2.5 % (photons/electron) (at 7.5 mA cm−2), a low turn‐on voltage and high emission intensity (luminance) of 5500 cd m−2 (at 250 mA/ m2).