bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endocrine function after immunosuppression of pancreatic allograft by ionizing irradiation in the primate
Authors: Du Toit Don F. , Heydenrych Jacobus J. , Smit Ben , Louw Gabriel , Zuurmond Theuns , Laker Lida , Els Daniel , Weideman Andre , Wolfe‐Coote Sonja , Du Toit L. B. , Davids H. 
Published: February 2007

AbstractThe object of this preliminary study was to evaluate the endocrine function after heterotopic intraperitoneal segmental pancreatic allotransplantation with unligated duct in irradiated, totally panreatectomized primates. All allograft recipients received, pre‐ and peroperative donor‐specific blood transfusions and peroperative external irradiation from a linear accelerator; 200 rads was administered weekly and increased to a total dose of 1,500 rads. Pancreatic transplantation was performed between 2 and 6 weeks after completion of irradiation and preoperative blood transfusions. As previously reported, only minimal pancreatic allograft survival was achieved following preoperative irradiation. One recipient remained normoglycaemic for > 100 days after transplantation, The longest surviving pancreatic allograft recipient reported from this laboratory. Intravenous glucose tolerance test results in this recipient revealed normoglycaemia, reduced K‐value, hypoinsulinaemia, normal glucagon response, reduced C‐peptide values, and moderate glucose intolerance. Aortography and electron‐microscopic examination of allograft biopsy tissue confirmed the presence of a functioning allograft.
Four primary malignant neoplasms in a single patient
Authors: Craig David M. , Triedman Leonard J. 
Published: February 2007

AbstractA 60‐year‐old Caucasian male, with a previous history of a 10‐year occupational exposure to ionizing radiation, chemical carcinogens, and a long history of tobacco and alcohol abuse, developed synchronous squamous cell carcinoma of the floor of the mouth and adenocarcinoma of the lung. Four years later, squamous cell carcinoma of the larynx followed by squamous cell carcinoma of the tongue were diagnosed. in this case report, we suggest that increased exposure to multiple carcinogenic factors may result in an increased incidence of both synchronous and metachronous primary malignant neoplasms.
Polyps of the gallbladder
Authors: Majeski James A. 
Published: February 2007

AbstractOne of the unusual problems associated with gallbladder disease is a polyp discovered by either ultrasonography or by oral cholecystogram. We report a recent experience of two cases of polyps of the gallbladder removed by cholecystectomy. The incidence of gallbladder polyps of any type is quite varied in the medical literature. Eighty percent of polyps occur in females, and these occur after the third decade of life. The polyps can either be cholesterol or inflammatory polyps that are not really benign tumors but just reactions of the gallbladder wall. The true mucosal benign lesions are either adenomyomas or papillomas. The adenomyomas and papillomas have malignant potential. There are case reports of carcinoma in situ and cancer arising from these lesions. The treatment for a gallbladder polyp is a cholecystectomy.
Metastases to the corpora cavernosa from transitional cell carcinoma of the bladder
Authors: Haddad Farid S. , Kivirand Ariadna I. 
Published: February 2007

AbstractA case of penile metastases secondary to transitional cell carcinoma of the bladder is reported. The patient was treated with chemotherapy and had the longest survival ever reported for this conditon: 20 months; this compares favorably with the 4‐month average survival of patients treated by surgery and/or radiotherapy.
Renal cell carcinoma presenting as a single large cyst
Authors: Sarma Deba P. , Weilbaecher Thomas G. , Waggenspack Gerard A. 
Published: February 2007

AbstractA large single renal cyst occurring in a 56‐year‐old man was found to be a cystic renal cell carcinoma on surgical exploration. Various diagnostic tests preoperatively did not reveal the true nature of the cyst.
Effect of liquid diet on nude mouse gastrointestinal tract
Authors: Johnson Frank E. , Awad Elene M. , Jellinek Max , Deveney Clifford W. , Laregina Marie C. 
Published: February 2007

AbstractThe nude (athymic) mouse is currently used to study the effect of gastrin on cancer xenografts. We sought to develop a hypogastrinemic nude mouse model for use in evaluating the effect of hypogastrinemia on such xenografts. Thirty‐six non‐tumor‐bearing nude mice were studied. Eighteen received a nutritionally complete liquid diet; eighteen received standard chow. Six mice from each group were weighed and killed (nonfasting) on days 2, 8, and 15. Mean serum gastrin levels (± SEM) for the control group were 118.7 ± 7.5, 118.7 ± 8.7, and 118.0 ± 7.5 pg/ml on days 2, 8, and 15, respectively. Serum gastrin levels for the liquid diet group significantly decreased to 87.0 ± 7.6, 88.0 ± 9.7, and 66.7 ± 9.6 pg/ml on the same days. Animals in both groups gained weight normally; there were no significant weight differences between the two groups at any point. No histological abnormalities were seen in stomach, small intestine, colon, cecum, liver, pancreas, spleen or kidney. However, The liquid diet group showed atrophic changes in colon: significant reductions in colon weight and RNA content on days 8 and 15, and significant reduction in colon protein content on day 8. This model of hypogastrinemia is reliable and inexpensive. The nonsurgical nature of the preparation allows excellent survival in this immunodeficient animal.
Myoepithelioma of the breast: Histologic, immunologic, and electromicroscopic appearance
Authors: Bigotti Giulio , Giorgio Carmelo Giacomino Di 
Published: February 2007

AbstractThis report describes the histologic, immunologic, and ultrastructural features of a distinctive spindle‐cell tumor of the female breast interpreted as pure myoepithelioma. By light microscopy, The tumor showed the mammary parenchyma replaced by bundles of fusiform cells, which cytoplasms contained myosin and actin, demonstrated immunologically. Ultrastructurally, The spindle cells were joined by mature desmosomes and presented parallel bundles of microfilaments and remnants of basal lamina.
A preliminary report on the suitability of sheep epidermal squamous cell carcinoma as a solid tumor model in the evaluation of intra‐arterial methotrexate administration
Authors: Harker Garry J. S. , Stephens Frederick O. , Wass Jane , Zbroja Rosemary A. , Chick Bruce F. , Grace Julienne 
Published: February 2007

AbstractA preliminary study was undertaken to assess the sensitivity of sheep epidermal squamous cell carcinoma, in the head and neck region, to intraarterial (IA) methotrexate (MTX) infusion. There was an objective tumor response (40‐56% regression) in all three IA‐infused sheep, whereas tumor progression was observed in all three animals treated intravenously (IV). Regional and systemic side effects were negligible in all cases. Technically, IA drug infusion in the sheep was an improvement on previous small animal models, with no problems related to arterial catheter insertion, blockage, or dislodgement, and tolerable infusion times being of markedly longer duration. The histological differentiation of moderately differentiated stage II lesions improved during therapy irrespective of clinical response, whilst the histology of well‐differentiated stage III and IV tumors remained unchanged. Tumor cell cycle stage and ploidy characteristics, as determined by flow cytometric DNA analysis, were little affected by either mode of drug administration. It is concluded that sheep epidermal carcinoma is responsive to IA MTX, and that this animal model is the most appropriate yet utilised to study the comparative effects of IA and IV chemotherapy in the head and neck region.
Leiomyosarcoma of meckel's diverticulum: A case report and review of the literature
Authors: Saadia R. , Decker G. A. G. 
Published: February 2007

AbstractA case of leiomyosarcoma of a Meckel's diverticulum, presenting as an acute appendicitis, is reported. The literature is reviewed with particular emphasis on current trends in the diagnosis and management of leiomy osarcomas of the small intestine.
Cardiac tamponade as the only initial feature of malignancy: A case report and review of the literature
Authors: Shinde Shashank R. , Shaha Pravin B. , Shetty Prabhakar A. 
Published: February 2007

AbstractCardiac involvement in the form of pericardial effusion or tamponade as the initial feature of extracardiac malignancy is extremely rare. An extensive search of medical literature yielded only 36 such cases. A case is presented and literature reviewed.
The treatment of nonseminomatous testicular tumors: 15 years experience
Authors: Steiner M. , Stein M. , Cohen Y. , Robinson E. 
Published: February 2007

AbstractThirty‐two patients with nonseminomatous germ cell tumors of the testis were treated at the Northern Israel. Oncology Center during the years 1968‐1983. The patients were divided into two groups. Group I included 18 patients treated from 1968 to 1976; in group II there were 14 patients treated with combination therapy containing cis‐platinum in the years 1977 to 1983. The actuarial survival rate at 38 months from diagnosis is 47% in group I patients and 86% in group II patients. The development of modern radiological techniques, biochemical markers for accurate staging, and the use of cis‐platinum‐containing combination chemotherapy made this disease curable. New treatment modalities are needed for patients with bulky disease at presentation.
Evaluation of routine follow‐up after surgery for breast carcinoma
Authors: Marrazzo Antonio , Solina Gaspare , Puccia Vincenzo , Fiorentino Eugenio , Bazan Pietro 
Published: February 2007

AbstractClose postoperative follow‐up of patients with breast cancer permits the early detection of possible recurrence of disease. Such follow‐up allows for the detection of a tumor mass, that is small enough to permit adequate treatment leading to an increased survival time and better quality of life. Thus we studied 85 patients treated by radical mastectomy in stages I, II, and III during the period from December 1977 to June 1982. Among 82 patients, 41 had axillary node involvement and received adjuvant chemotherapy with C.M.F. All patients received a strict follow‐up. Thirty‐two patients showed recurrence of the disease, with 28. 1% being discovered while still asymptomatic. Seventy‐five percent of the recurrences were in the first 24 months after treatment. The frequency of involved sites was different between the group of patients with involvement and the group without involvement of axillary nodes. We have concluded that in asymptomatic patients certain exams need not be repeated at frequent intervals, and we have proposed a new follow‐up protocol.
Reaction of the tumor markers cea and tpa to a surgical trauma
Authors: Putzki H. , Student A. , Breucker K. , Jablonski M. 
Published: February 2007

AbstractThe level of the tumor marker tissue polypeptide Antigen (TPA) rises distinctly after a surgical trauma. The rise begins between 3 and 6 days after operation; the elevation lasts for more than 6 weeks. Carcinoembryonic antigen (CEA) shows no comparable reaction.
Management of acute rectal problems in leukemic patients
Authors: Boddie Arthur W. , Bines Steven D. 
Published: February 2007

AbstractIn the interval 1944‐1983, 54 patients with leukemia and acute rectal pathology were seen at our institution, including: 25 patients with perirectal abscesses and/or fistulas (PF/F), 16 patients with acutely prolapsed or thrombosed hemorrhoids, 11 patients with anal fissures with or without hemorrhoids, and 2 patients with perianal excoriations. In the past, concerns have been raised about development of septicemia secondary to diagnostic or therapeutic instrumentation. In only 4 of 54 cases did the clinical course clearly suggest digital examination or instrumentation of the rectum may have caused bacteremia though 13 of 54 patients had positive blood cultures for gram negative organisms at some time during their course of which 7 were clearly coliform. Most (42/54) patients were treated initially by sitz baths, suppositories, and stool softeners and/or antibiotics. We observed five patients only and treated two by radiotherapy. Eleven patients required surgical intervention for thrombosed hemorrhoids and perirectal abscess and/or fistulas. Eight other patients with PA/F drained spontaneously. Poor healing after surgical or spontaneous drainage was documented in only one case. This study suggests that sitz baths, suppositories, antibiotics, and judicious surgical drainage (where needed) form the core of therapy for these patients.
Basal cell carcinoma with lung metastases: A case report
Authors: Icli Fikri , Uluoglu Omer , Yalav Erdogan , Isikman Erdogan 
Published: February 2007

AbstractMetastases from basal cell carcinoma (BCC) are very rare. Some clinical and histologic features have been demonstrated in these cases without corroborative evidence.Treatment of these cases has been disappointing. In this article, we report a patient with metastatic BCC who was treated successfully by surgical resection of lung metastases.
Enteral and parenteral nutrition in anorectic patients with advanced gastrointestinal cancer
Authors: Lindh Annika , Cedermark Björn , Blomgren Henric , Wasserman Jerzy , Petrini Björn 
Published: February 2007

AbstractSeventeen patients with advanced, noncurable gastrointestinal cancer with symptoms of anorexia and malnutrition were treated with controlled enteral or total parenteral nutrition over a 3‐week period. Eleven patients received enteral and six parenteral nutrition. The nutrition was given with 30‐40 kcal/kg b.w. daily. No anticancer treatment was given. Before and after the treatment period, the patients were assessed regarding their nutritional, immunological, and performance status.None of the studied nutritional parameters changed significantly over the 3‐week period and there was no clear indication of an improved lymphocyte reactivity. There was a tendency toward improvement in performance status for the patients on enteral nutrition, while the reverse seemed to be true for the parenteral group. It is concluded that nutritional support may halt the progressive malnutrition often seen in patients with cancer and serve as a palliative treatment in selected patients.
Implantable venous access devices: An alternative method of extended cancer care
Authors: Welling Richard E. , Hall James M. , Meyer Richard L , Arbaugh James J. 
Published: February 2007

AbstractThe advent of totally implantable venous access devices (TIVADs) is changing the method of treatment for those chronically ill patients who require long‐term chemotherapy or narcotic infusion. TIVADs eliminate the problem of limited peripheral vein access with little risk of complication. At Good Samaritan Hospital in Cincinnati, Ohio, we have implanted 30 TIVADs (3 Infuse‐A‐Ports and 27 Port‐a‐Caths) for a total of 4,502 patient days. This report documents our experience with the implantation and utilization of TIVAD systems.
Leiomyoma of the anal canal: Report of two cases
Authors: Witz Misha , Bernheim Joëlle , Griffel Benjamin , Dinbar Alex 
Published: February 2007

AbstractLeiomyoma of the rectum and anal canal is an unusual clinical entity. Generally, it does not produce any clinical signs and in most cases it is discovered incidentally in the course of routine rectal examination. The clinical presentation, diagnosis, and surgical treatment are described in two presented cases of anal canal leiomyoma.
Pilomatrix carcinoma
Authors: Chen Karl T. K. , Taylor David R. 
Published: February 2007

AbstractThe clinicopathologic features of two cases of pilomatrix carcinoma are described and compared with those of the 11 previously reported cases. In contrast with its benign counterpart, pilomatrix carcinoma occurs in older patients and there is a male‐predominating sex ratio. The rate of local recurrence is 60%. A single instance of distant metastasis occurred when the tumor recurred locally for the second time. Pilomatrix carcinoma can be accurately diagnosed histologically. The consistent features present in pilomatrix carcinoma but absent in the benign counterpart are increased mitotic activity and cytologic abnormalities including cellular and nuclear enlargement, and vesicular appearance of the nuclei. The primary lesion should be treated aggressively to prevent local recurrence, which may be a factor favoring distant tumor metastasis.
Lung cancer in men aged 40 or younger
Authors: Sarma Deba P. , Byers Virgil J. 
Published: February 2007

AbstractTwenty‐nine cases of lung cancer occurring in men aged 40 or less were examined at autopsy. Histologic types of cancer and metastatic patterns in this group of patients were similar to those seen in middle‐aged or elderly patients except for a lower occurrence of lymphatic spread in the younger group.
Bilateral ovarian involvement as the only manifestation of malignant lymphoma
Authors: Piura Benjamin , Bar‐David Jury , Glezerman Marek , Zirkin Howard J. 
Published: February 2007

AbstractA 16‐year‐old girl presented with a large pelvic mass. At laparatomy, bilateral ovarian tumors were disclosed and bilateral salpingo‐oophorectomy was performed. No evidence of extraovarian disease was found. Histopathological examination and histochemical immunoperoxidase studies demonstrated the tumors to be malignant lymphoma of the lymphoblastic type. The patient had radiotherapy and systemic chemotherapy and more than 10 years later she is alive with no evidence of recurrent disease. The rarity of ovarian involvement as the initial manifestation of malignant lymphoma is discussed. The question of whether this patient represents a case of a primary ovarian malignant lymphoma or merely represents a case of ovarian initial manifestation of an occult generalized disease cannot be answered.
Testicular seminomas in saudi arabia: Clinical characteristics, prognostic indicators, and recommendations for management
Authors: Bissada Nabil K. , Senoussi Mohammed El , Hanash Kamal A. , Hefty Thomas , Morcos Rafik 
Published: February 2007

AbstractThirty Saudi patients with pure testicular seminoma were treated at King Faisal Specialist Hospital and Research Centre in Riyadh, Saudi Arabia, between January 1977 and June 1983. Disease characteristics in Saudi Arabia including clinical findings, response to therapy, and prognosis are described and compared to those in other populations reported in the literature. Symptom durations were 3 to 42 months. Many of the patients presented with an extensive tumor burden and a poor performance status. There was a higher incidence of anaplastic seminoma and of cryptorchidism man in other series and a relatively high incidence of elevated betahuman chorionic gonadotropin (B‐HCG). Patients initially underwent funiculo‐orchiectomy. Twenty‐two patients received radiation therapy and four received chemotherapy. Patients with limited disease responded well to orchiectomy and radiation therapy. However, those‐with extensive tumor burden had an unsatisfactory response to radiation therapy. Preradiation chemotherapy is recommended for 1) patients with massive retro‐peritoneal metastases, nodal disease above the diaphragm, or extranodal disease and 2) patients with minimal or moderate sized retroperitoneal nodal disease associated with an elevated B‐HCG.
Experiments evaluating antitumor immunity induced by cholesterol hemisuccinate‐treated syngeneic cell vaccines
Authors: Rong Guo Huang , Sindelar William F. 
Published: February 2007

AbstractEvaluation of the efficiency of immunizations with syngeneic tumor vaccines prepared from cells treated with cholesterol hemisuccinate (CHS) was performed in five animal models: P815 mastocytoma in DBA/2 mice, MCA‐103 fibrosarcoma in C57BL/6N mice, L1210 leukemia in DBA/2 mice, Ehrlich ascites carcinoma in C57BL/6N mice, and CBP pancreatic cancer in CB/SsLak hamsters. Animals received two to four weekly intraperitoneal immunizations with 106 or 107 tumor cells, followed by challenges with syngeneic viable tumor cells. Survival and tumor growth rates were observed. No significant differences were observed among animals immunized with CHS‐treated irradiated tumor vaccines, non‐treated irradiated tumor vaccines, and nonimmunized controls in the P815, MCA‐103, L1210, and CBP models. Mice immunized with nontreated irradiated Ehrlich ascites cell vaccines showed longer survival than those immunized with CHS‐treated irradiated cell vaccines and nonimmunized controls. Results indicated that CHS‐treated tumor cell vaccines were not effective in protecting against tumor challenges in five different syngeneic tumor models.
Diagnostics of small gastric carcinoma
Authors: Oiwa Toshio , Mori Masaki , Sugimachi Keizo , Enjoji Munetomo 
Published: February 2007

AbstractWe studied the diagnostic features of 32 early gastric carcinomas less than or equal to 1 cm in maximum diameter, which were detected in 28 patients. A correct preoperative qualitative diagnosis was made in 19% of the lesions by means of barium studies, in 72% by endoscopy, and in 90% by endoscopic biopsy. Endoscopy and endoscopic biopsies are the most useful diagnostics for detection of these small cancers. Since most carcinomas with a diameter between 6 and 10 mm have a mucosal unevenness such as a shallow depression with an irregular perimeter and are associated with or without elevated marginal mucosa on gross inspection, it was not very difficult to detect these carcinomas with careful endoscopic observations. When endoscopists procure such evidence, biopsies should be done for confirmation. Even in ulcers that appear benign, biopsies are recommended. With regard to carcinomas of less than or equal to 5 mm in diameter, it is difficult to detect the lesions, particularly the flat‐type, which make up a relatively large percentage of those minute carcinomas.
The value of the wright‐giemsa stain for diagnosing hairy cell leukemia in body cavity fluids
Authors: Strobel Stephen L. , Brandt John T. 
Published: February 2007

AbstractWe compared the value of the Wright‐Giemsa stain with the Papanicolaou stain for diagnosing hairy cell leukemia in the body cavity fluids of three patients. The cytological features of the leukemic cells were much clearer on the Wright‐Giemsa‐stained preparations. This allowed for the accurate diagnosis of leukemic involvement of the body cavity fluids in 3/3 patients using the Wright‐Giemsa stain but only 1/3 using the Papanicolaou stain. A tartrate‐resistant acid phosphatase stain was used to confirm the diagnosis in each case.
Interferon‐β treatment of metastatic prostate cancer
Authors: Bulbul M. A. , Huben R. P. , Murphy G. P. 
Published: February 2007

AbstractA limited clinical trial of Interferon‐β (Human Fibroblast Interferon) in the treatment of advanced, hormone‐refractory postate cancer was conducted by the National Prostate Cancer Project (NPCP Protocol 2100). Sixteen patients with metastatic prostate cancer who had failed prior hormone therapy were entered into the study. Treatment consisted of 6 × 106 units of Interferon‐β intravenously three times per week for 12 weeks. Chills and fever were seen in ten of the 16 patients (62.5%), and mild hematologic toxicity occurred in four patients. No complete or partial responses were observed. Three patients had stable disease by NPCP criteria for a mean duration of 6.3 months. Progression of disease was seen in 13 of the 16 patients, eight of whom progressed during therapy. The results of this study suggest that Interferon‐β has limited efficacy in the treatment of advanced, horomone‐refractory prostate cancer.