bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does dynamic balance affect cube mental rotation task in badminton vs. volleyball female players?
Authors: Amara Samiha , Al-Hadabi Badriya , El-Ashkar Heba , Gmada Nabil , Habacha Hamdi , Mkaouer Bessem 
Published: March 2024

Abstract
Background
Changing from a static to a dynamic balance condition could affect the performance of a cognitive task such as mental rotation. Thus, the main goal of this study is to investigate aspects of visual-spatial cognition between two non-contact sports (i.e., badminton and volleyball) in different upright conditions (i.e., standing position, frontal balance, and sagittal balance).

Methods
Thirty-five volunteer female sports and physical education students, fourteen specialists in badminton and twenty-one specialists in volleyball agreed to participate in this study. Each of the assessments was a 3D cube mental rotation task with and/or without balance exercises (i.e., frontal and/or sagittal balance) on a wobble board. Five stimuli were used in the mental rotation task (i.e., 45°, 135°, 180°, 225° and 315° for objected-based cube condition with egocentric transformation) which included pairs of standard and comparison images.

Results
The findings indicate that there was a notable decrease (p < 0.001; d = 1.745) in response time in both dynamic balance conditions (i.e., frontal and sagittal balance) compared to standing position condition. In addition, results revealed significant interaction between balance conditions (i.e., frontal and/or sagittal balance) and groups (i.e., badminton and volleyball) in the response time at 225° angle and in the error percentage.

Conclusions
In sum, dynamic balance is also an activity that involves mental manipulation of objects in 3D space, which can enhance badminton and volleyball female players’ ability to rotate 3D cube stimuli.
Improving the performance of a spectral model to estimate total nitrogen content with small soil samples sizes
Authors: Tang Weihao , Hu Wenfeng , Li Chuang , Wu Jinjing , Liu Hong , Wang Chao , Luo Xiaochuan , Tang Rongnian 
Published: March 2024

AbstractThe application of near-infrared spectroscopy (NIRS) for rapid quantitative analysis of soil total nitrogen (STN) is of great significance to recycling nitrogen in the ecosystem and crops growth. However, collecting thousands of soil samples and chemical analysis are impracticable, more importantly a deviation from NIRS advantages of rapid, inexpensive and nondestructive. To more efficiently improve the estimation performance and reduce uncertainty of the model when working with small sample sizes (less than 100), solutions from soil particle size decomposition and model fusion were investigated. Elaborately, 123 Latosols samples were collected and decomposed them according to particle sizes to extend limited data at multiple scales. Based on all soil groups decomposed, a hyperspectral data recapture and model decision fusion method were implemented. The results demonstrated that the proposed method increased the scale of spectral data, extracted more STN-related spectral information, improved estimation accuracy, and reduced uncertainty. The fused model based on data from all decomposed groups yielded the best estimated results (root mean square error $$(RMSE) = 0.075g.kg^{-1}$$

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.
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, $$R^2 = 0.784$$

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, and a ratio of performance to inter-quartile distance $$(RPIQ) = 3.787$$

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=
3.787

) on the validation set. Through a tenfold cross-validation, the weighted fusion model with six groups of particle sizes data showed an improvement of 0.307 in $$R^2_cv$$

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c
2

v

and an improved RPIQ of 1.015 compared to models constructed using conventional machine learning (ML) techniques and limited pristine data ($$R^2_cv = 0.442, RMSE = 0.119$$

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=
0.442
,
R
M
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=
0.119

). Therefore, when utilizing NIRS to build rapid and accurate STN predictive models, the proposed method demonstrates great potential in improving the reliability of soil spectral models under small sample sizes.
Graphical Abstract
A balancing act: navigating the nuances of co-production in mental health research
Authors: Soklaridis Sophie , Harris Holly , Shier Rowen , Rovet Jordana , Black Georgia , Bellissimo Gail , Gruszecki Sam , Lin Elizabeth , Di Giandomenico Anna 
Published: March 2024

Abstract
Background
In the context of mental health research, co-production involves people with lived expertise, those with professional or academic expertise, and people with both of these perspectives collaborating to design and actualize research initiatives. In the literature, two dominant perspectives on co-production emerge. The first is in support of co-production, pointing to the transformative value of co-production for those involved, the quality of services developed through this process, as well as to broader system-level impacts (e.g. influencing changes in health system decision making, care practices, government policies, etc.). The second stance expresses scepticism about the capacity of co-production to engender genuine collaboration given the deeply ingrained power imbalances in the systems in which we operate. While some scholars have explored the intersections of these two perspectives, this body of literature remains limited.

Main text
This paper contributes to the literature base by exploring the nuances of co-production in health research. Using our mental health participatory action research project as a case example, we explore the nuances of co-production through four key values that we embraced:

Navigating power relations together

Multi-directional learning

Slow and steady wins the race

Connecting through vulnerability

Conclusions
By sharing these values and associated principles and practices, we invite readers to consider the complexities of co-production and explore how our experiences may inform their practice of co-production. Despite the inherent complexity of co-production, we contend that pursuing authentic and equitable collaborations is integral to shaping a more just and inclusive future in mental health research and the mental health system at large.
The histone deacetylase UvHOS2 regulates vegetative growth, conidiation, ustilaginoidin synthesis, and pathogenicity in Ustilaginoidea virens
Authors: Long Zhaoyi , Wang Peiying , Yu Qianheng , Wang Bo , Li Dayong , Yang Cui , Liu Ling , Duan Guohua , Sun Wenxian 
Published: March 2024

AbstractUstilaginoidea virens causes rice false smut, one of the most devastating rice diseases. The pathogen produces various types of mycotoxins, such as ustilaginoidins and ustiloxins, which are harmful to both human and animal health. Histone deacetylases in fungi play an important role in regulating chromatin structure and gene expression. However, there is limited knowledge about how histone deacetylases control pathogenicity and mycotoxin biosynthesis in U. virens. Here, we characterize a putative class I histone deacetylase UvHOS2 in U. virens. The UvHos2-deletion mutants exhibit retarded vegetative growth, reduced conidial production and germination, and attenuated virulence. UvHOS2 positively regulates tolerance to various environmental stresses, including cell wall, cell membrane integrity, osmotic and oxidative stresses. UvHOS2 reduces the acetylation levels of histones at multiple Lys sites, including H3K9, H3K14, H3K27, and H3K56. ChIP-PCR assays revealed that UvHOS2-mediated H3K9 deacetylation regulates the expression of ustilaginoidin biosynthesis genes. Consistently, transcriptome analysis indicates that UvHOS2 regulates the expression of the genes involved in secondary metabolism, mycelial growth, conidiogenesis, and pathogenicity, thereby controlling U. virens virulence and mycotoxin (ustilaginoidins and sorbicillinoids) biosynthesis. This study provides a theoretical reference for revealing the epigenetic regulation of pathogenicity and mycotoxin biosynthesis in plant pathogenic fungi.
Pattern of body fat distribution in patients of PCOS using DEXA-based indices
Authors: Birjees Sanna , Jehangir Majid , Rasool Mirza Vamiq , Amin Fiza , Qayoom Seema 
Published: March 2024

Abstract
Background
Considering the close link between polycystic ovary syndrome (PCOS) and metabolic syndrome considerable research has been devoted to studying the pattern of fat distribution in PCOS.

Objectives
The study aims to assess the usefulness of dual-energy X-ray absorptiometry (DEXA) based regional fat distribution indices as a predictor of the development of PCOS.

Methods
This case–control study recruited diagnosed cases of PCOS using Rotterdam Criteria (cases n = 86) and healthy age-matched controls (n = 90). DEXA was performed in both groups for assessment of total and regional body fat distribution after undergoing ultrasonography (USG) and baseline/biochemical evaluation.

Results
The study revealed a significant difference between cases and controls in trunk fat percentage (40.2% ± 9.1% vs 26.5% ± 9.1%; p < 0.001), android fat percentage (42.4% ± 41%vs 27.8% ± 1.51%; p < 0.001), total fat percentage (43.8% ± 8% vs28.5% ± 1.6%; p < 0.001), fat mass/ht2 (fat mass index) (8.82 ± 3% vs 4.8 ± 1.7%; p < 0.001), android/gynoid ratio (1.05 ± 0.1 vs 0.7 ± 0.2; p < 0.001), and trunk/limb fat mass ratio (1.06 ± 0.3 vs 0.69 ± 0.3; p 0.001). Multivariate analysis revealed a significant relation of trunk fat mass with android % fat, gynoid fat mass, and android-gynoid ratio.

Conclusions
The study demonstrates that there is a central pattern of fat distribution in patients with PCOS while the overall fat might not be increased which is well analyzed by DEXA. Hence, we suggest its use in the initial diagnostic workup and follow-up of PCOS patients for their body fat distribution and content.
Evaluation of molecular subtypes of breast cancer using MRI BI-RADS Lexicon
Authors: Shokeir Farah A. , Soliman Nermin , Khater Ashraf , Bayoumi Dalia 
Published: March 2024

Abstract
Background
Molecular subtyping of breast cancer is one of the prognostic factors which play a very important role in managing patient’s treatment plan. The MRI BI-RADS Lexicon is initially used to categorize breast lesions but recent attempts were employed to differentiate breast lesions based on their molecular subtypes using this lexicon. The study aimed to evaluate of the role of the MRI BI-RADS Lexicon in classifying different molecular subtypes of breast cancer especially after coupling with Kaiser scoring system.

Methods
This retrospective study was conducted on 147 patients with 170 malignant breast lesions. They underwent Pre-contrast and a Dynamic contrast MRI study. Retrospective interpretation of the morphological and dynamic criteria of the breast lesions based on the MRI BI-RADS criteria was carried out followed by reassessment of the same lesions by Kaiser scoring. Resulting data were correlated with histopathological and immunological characterization.

Results
Luminal subtypes were more frequently encountered as mass lesions, contrary to the Non-Luminal lesions which showed a more frequent non-mass presentation value (P 0.002). The shape, margin, internal enhancement pattern of the mass lesions showed significant variability between different molecular subtypes (P < 0.001, < 0.001, < 0.001) respectively. On Dynamic study, Plateau curve was a more evident pattern with Luminal lesions contrasting with their Non-Luminal counterparts which showed a washout pattern more frequently (P 0.0004). Most of luminal A cancers were presented as mass lesions with rim enhancement and categorized as BIRADS 4 while most of Her2neu positive cancers (including luminal B entity) were presented as non-mass lesions with irregular shape and dark internal septations and categorized as BIRADS 5 with statistically significant values (P < 0.001). Coupling with Kaiser scoring system improved the categorization of non-luminal tumors as BIRADS 5 lesions especially the aggressive TN cancers.

Conclusions
MRI-BIRADS lexicon can be of great value in the non-invasive molecular characterization of breast cancer. Kaiser score improved the categorization of TN cancers which were upgraded to BIRADS 5 category.
Implications of Immunogenicity Testing for Therapeutic Monoclonal Antibodies: A Quantitative Pharmacology Framework
Authors: Williams Jason H. , Liao Kai H. , Yin Donghua , Meng Xu 
Published: March 2024

AbstractThe interpretation of immunogenicity results for a mAb product and prediction of its clinical consequences remain difficult, despite enormous advances in methodologies and efforts toward the best practice for consistent data generation and reporting. To this end, the contribution from the clinical pharmacology discipline has been largely limited to comparing descriptively the pharmacokinetic (PK) profiles by antidrug antibodies (ADA) status or testing the significance of ADA as a covariate in a population PK setting, similar to the practice for small-molecule drugs in investigating the effect of an intrinsic/extrinsic factor on the drug disposition. There is a need for a mAb disposition framework that captures the dynamics of ADA formation and drug’s interactions with the ADA and target as parts of the drug distribution and elimination. Here we describe such a framework and examine it against the PK, ADA, and clinical response data from a phase 3 trial in patients treated with adalimumab. The proposed framework offered a generalized understanding of how the dose, target affinity, and drug/ADA analyte forms affects the manifestation of ADA response with regard to its detections and alterations of drug disposition and effectiveness. Furthermore, as an example, its utility for dose considerations was demonstrated through predicting for late-stage trials of a PCSK9 inhibitor in terms of development in ADA incidence and titers, and consequences on the drug disposition, interaction with target, and downstream lowering effect on LDL-C.
Graphical Abstract
Endoscopic Supracerebellar Infratentorial Transpineal Approach for Posterior-Medial Thalamic Lesions: Surgical Technique and Clinical Experience
Authors: Xie Tao , Liu Shuang , Zhang Xiaobiao , Yang Liangliang , Liu Tengfei , Chen Ping , Li Zeyang 
Published: March 2024

BACKGROUND AND OBJECTIVES:
Accessing lesions in the posterior-medial thalamus can be challenging because of their deep location and intricate neurovascular anatomy. This study aims to describe the techniques and feasibility of the endoscopic supracerebellar infratentorial transpineal approach for treating posterior-medial thalamus lesions.

METHODS:
We reviewed and analyzed the clinical outcomes and endoscopic surgical experience of 11 patients with posterior-medial thalamic lesions. The first 4 cases used the endoscopic midline supracerebellar infratentorial transpineal approach, whereas the subsequent 7 cases used the endoscopic contralateral paramedian supracerebellar infratentorial transpineal approach. All cases involved the upward transposition of the pineal gland to access the posterior-medial thalamus. The extent of resection and the endoscopic techniques were the main focus of analysis. Neurological examinations and MRI/computed tomography follow-up were conducted for 3–12 months after surgery.

RESULTS:
The pathology of the group included 6 gliomas, 1 cavernous malformation, 1 inflammation, 1 melanoma, and 2 hematomas. All 11 patients achieved gross total resection (6 patients, 54.5%) or subtotal resection (5 patients, 45.5%) with no new neurological deficits. Most patients (9 patients, 81.8%) experienced improvement in Karnofsky Performance Status after surgery. Postoperative hydrocephalus occurred in 2 patients (18.2%) and was relieved by endoscopic third ventriculostomy.

CONCLUSION:
The endoscopic supracerebellar infratentorial transpineal approach is an effective approach for removing posterior-medial thalamic lesions that require access through the third ventricle surfaces of the thalamus. The endoscopic contralateral paramedian supracerebellar infratentorial transpineal approach provides a more superior and lateral view of the posterior-medial thalamic lesions.
Completely Minimally Invasive Implant Removal and Transforaminal Lumbar Interbody Fusion for Adjacent Segment Disease: Case Series and Operative Video
Authors: Kondapavulur Sravani , Scheer Justin K. , Safaee Michael M. , Clark Aaron J. 
Published: March 2024

BACKGROUND AND OBJECTIVES:
Adjacent segment disease is a relatively common late complication after lumbar fusion. If symptomatic, certain patients require fusion of the degenerated adjacent segment. Currently, there are no posterior completely minimally invasive techniques described for fusion of the adjacent segment above or below a previous fusion. We describe here a novel minimally invasive technique for both implant removal (MIS-IR) and adjacent level transforaminal lumbar interbody fusion (MIS-TLIF) for lumbar stenosis.

METHODS:
Demographic, surgical, and radiographic outcome data were collected for patients with lumbar stenosis and previous lumbar fusion, who were treated with MIS-IR and MIS-TLIF through the same incision. Radiographic outcomes were assessed postoperatively and complications were assessed at the primary end point of 3 months.

RESULTS:
A total of 14 patients (7 female and 7 male), with average age 64.6 years (SD 13.4), were included in this case series. Nine patients had single-level MIS-IR with single-level MIS-TLIF. Three patients had 2-level MIS-IR with single-level MIS-TLIF. Two patients had single-level MIS-IR with 2-level MIS-TLIF. Only 1 patient had a postoperative complication—hematoma requiring same-day evacuation. There were no other complications at the primary end point and no fusion failure at the hardware removal levels to date (average follow-up, 11 months). Average increases in posterior disk height and foraminal height after MIS-TLIF were 4.44, and 2.18 mm, respectively.

CONCLUSION:
Minimally invasive spinal IR can be successfully completed along with adjacent level TLIF through the same incisions, via an all-posterior approach.
A rare case of a hard-to-heal ulcer caused by pulmonary Nocardia infection
Authors: Zhu Wei , Shu Ziqin , Song Huapei 
Published: March 2024

Nocardiosis is an acute purulent or granulomatous disease caused by Nocardia spp. infection that commonly invades the lungs and central nervous system. Hard-to-heal wounds caused by Nocardia spp. infection are rare. A 63-year-old female patient underwent puncture biopsy due to a mass in the right lung. Subsequently, dermal ulceration occurred on her back at the biopsy site, with no improvement following treatment at multiple hospitals. After admission to our department, bacterial culture of sputum and discharge from the deep wound sinus revealed Nocardia asteroides infection. The treatment regimen was developed by a multidisciplinary team at our department. The patient underwent debridement and vacuum sealing drainage (VSD) and was administered imipenem. The wound was then sealed by local flap transfer. The patient was discharged from the hospital after the wound had healed and continued to take minocycline for 2 months. At 3 months post-discharge, the symptoms of lung infection had resolved. Nocardiosis mainly affects the lungs, and its clinical symptoms are similar to those of pulmonary tuberculosis. Nocardia infections can extend to the chest wall and form abscesses or cellulitis. For hard-to-heal wounds caused by Nocardia spp., local debridement combined with systemic anti-infective therapy should be applied. In this case study, the diagnosis of pulmonary and wound nocardiosis was confirmed based on clinical manifestations, imaging, aetiological investigation and pathology. The treatment regimen was debridement combined with VSD, as well as a full course of antibiotics. The optimal treatment regimen for hard-to-heal wounds caused by Nocardia spp. includes effective debridement combined with VSD and long-course antibiotic therapy, which can improve the cure rate. Declaration of interest: The authors have no conflicts of interest.
Monolithic 24  cm2 flexible triple-junction solar cell encapsulated module based on the ipsilateral electrode welding technology
Authors: Luo Xiaolong , Long Junhua , Sun Qiangjian , Chen Zhitao , Wu Xiaoxu , Li Xufei , Yu Menglu , Zhao Huyin , Shen Xiaoming , Lu Shulong 
Published: March 2024

The inverted metamorphic multi-junction solar cell is anticipated to be widely applied in stratospheric flight because of its exceptional properties of flexibility and light weight. We propose an ipsilateral welding technology based on Ti/Au electrodes to simplify the fabrication process of GaInP/GaAs/InGaAs solar cells and encapsulate large-sized flexible solar cells. After annealing at 200°C for 2 h, the Ti/Au electrode achieved a low specific contact resistivity of 2.9×10−7Ω⋅cm2. The performance of the ohmic contact remains stable after the thermal cycling tests. The Ti/Au electrode can require less heat input for welding to reduce the risk of microcrack formation of the solar cells. By employment of this electrode, a 24cm2 solar cell achieved a conversion efficiency of 34.74%. A flexible solar cell module with an efficiency of 32.82% under AM 1.5G illumination was obtained by the ipsilateral electrode welding technology.
Power-modulated integrated path differential absorption lidar for probing benzene concentration
Authors: Liu Jiahui , Li Shichun , Wang Yi , Guan SiYu , Hua Dengxin , Xin Wenhui , Song Yuehui 
Published: March 2024

Aimed at the regional open-path detection of benzene (C6H6) in the atmosphere, a power-modulated integrated path differential absorption (PM-IPDA) lidar is introduced and demonstrated. Two tunable interband cascade lasers (ICLs) with about 3.2 µm wavelength are utilized to generate the required PM optical signal. These two operation central wavelengths (CWs) of the PM-IPDA lidar are, respectively, 3236.6 and 3187.1 nm, which can mitigate the influence of significant gases such as H2O, CH4, and HCl on the detection performance. In this work, the fast Fourier transform algorithm is used to retrieve the measured values with the time resolution of 0.1 s corresponding to 104 sampling bins at the sampling rate of 100 kSps/s. The modulated frequency of the PM-IPDA lidar is selected as 10 kHz by laboratory experiments. The slow fluctuation characteristic of the benzene absorption spectrum within the vicinity region of 3.2 µm reduces the impact of small wavelength fluctuations on the performance of PM-IPDA lidar, although a scheme modulated only the driving current causes wavelength fluctuations of ∼±0.2nm. These laboratory experiments also indicate the PM-IPDA lidar can reduce the error resulting from 1/f noise. Open-path observation experiments show that the detection limit is about 0.60mg⋅m−3 and that the PM-IPDA lidar can be used for the regional open-path real-time detection of benzene.