bluuebunny/crossref_metadata_2025_split huggingface dataset:
Turkish Adaptation of the Frailty Index for Elders: A Methodologic Study
Authors: Genç Fatma Zehra , Uslu Arzu , Bilgili Naile 
Published: April 2024

Background and Purpose:Frailty is an important problem in the aging process and can be prevented or delayed when detected at an early stage. Therefore, appropriate measurement tools are needed to determine frailty. The study aimed to adapt the Frailty Index for Elders (FIFE) into Turkish.Methods:Data were collected from 300 older individuals between January and April 2023. Rasch analysis was used to evaluate the construct validity. The KR-20 reliability coefficient of the factor items was evaluated and interpreted for internal consistency.Results:The reliability coefficient of the scale was .98, item separation (item separation index) was 7.62, and item reliability was .98. The content validity, based on the opinions of seven experts, was found as .85. In general, the relationship between the total scores of the individuals in the first application and the scores of the individuals in the second application was .92.Conclusions:It was concluded that the seven-item single-factor FIFE was a valid and reliable tool to measure the frailty of older individuals living in Turkey.
Pengelompokan Lapangan Usaha Berdasarkan Level Skill Menggunakan Multidimensional Scaling dan K-Means Clustering
Authors: Rahayu Iskandar Aulia Nur Joviandi , Kesumawati Ayundyah 
Published: April 2024

Kementerian Ketenagakerjaan atau Kemnaker adalah salah satu kementerian atau penyelenggara urusan administrasi pemerintahan dalam bidang ketenagakerjaan atau tenaga kerja. Seseorang yang bekerja atau mampu melakukan kegiatan guna menghasilkan barang dan/atau jasa baik untuk memenuhi kebutuhan sendiri maupun untuk keperluan kelompok lain disebut tenaga kerja. Penempatan tenaga kerja pada lapangan usaha yang tersedia menjadi salah satu faktor pendukung pembangunan ekonomi yang dilakukan oleh pemerintah. Sehingga tenaga kerja berkeahlian perlu memperhatikan kelompok lapangan usaha sesuai skill yang dimiliki. Analisis Multidimensional Scalling dan K-Means Clusterring digunakan untuk mengetahui kondisi tenaga kerja berkeahlian di cluster lapangan usaha yang ada. Dari penelitian ini, didapatkan bahwa pengelompokkan menjadi tiga cluster, dengan cluster 1 beranggotakan 13 lapangan usaha, cluster 2 beranggotakan 2 lapangan usaha, dan cluster 3 beranggotakan 2 lapangan usaha.
A crystalline stannyne
Authors: Liu Liu Leo , Wang Xin-Feng , Hu Chaopeng , Li Jiancheng , Wei Rui , Zhang Xin 
Published: April 2024

Abstract

The synthesis of heteronuclear alkyne analogs incorporating heavier group 14 elements (R1−C≡E−R2, E = Si, Ge, Sn, Pb) has posed a longstanding challenge, with no previous reports on isolable compounds of this nature. Until now, neutral silynes (R1−C≡Si(L)−R2) and germynes (R1−C≡Ge(L)−R2) stabilized by a Lewis base have achieved sufficient stability for structural characterization at low temperatures. Here we show the isolation of a base-free stannyne (R1−C≡Sn−R2) at room temperature, achieved through the strategic use of a bulky cyclic phosphino ligand in combination with a bulky terphenyl substituent. Despite an allenic structure with strong delocalization of π-electrons, this compound exhibits adjacent ambiphilic carbon and tin centers, forming a unique carbon-tin multiple bond with ionic character. The stannyne demonstrates reactivity similar to carbenes or stannylenes, reacting with 1-adamantyl isocyanide and 2,3-dimethyl-1,3-butadiene. Additionally, its carbon-tin bond can be saturated by Et3N·HCl or cleaved by isopropyl isocyanate.
The Effect of Repetitive Transcranial Magnetic Stimulation (rTMS) on Perioperative Neurocognitive Disorders in Patients after Cardiac Surgery: Study Protocol for a Randomized Controlled Trial
Authors: Wang Jing , Wang Xuyang , Li Sijie , Yang Jinrong , Yan Xiang , Gao Jie , Jia XiuQin , Zuo long , Wu Anshi , Wei Changwei 
Published: April 2024

Abstract
Introduction: Perioperative neurocognitive disorders(PND)is one of the most common postoperative complications among elderly patients (above 65 years old) undergoing cardiac surgery. However, thus far, there have not been any effective therapies for managing PND. Recent research has shown that repetitive transcranial magnetic stimulation (rTMS) alters brain plasticity and improves cognitive function in several neurodegenerative disorders and psychiatric disorders. However, the potential benefits of rTMS in reducing PND in patients undergoing cardiac surgery have not been investigated. Therefore, the current protocol is designed to determine whether rTMS can reduce the incidence of PND in patients undergoing cardiac surgery. Methods and analysis: The study will be a single-blinded, randomized controlled trial. Participants undergoing elective cardiac surgery will be randomized to receive either rTMS or sham stimulation with a focal figure of eight coils over the right dorsolateral prefrontal cortex. A series of neuropsychological tests will be completed to evaluate cognitive function in surgery patients before, on day 7, and on day 30 after cardiac surgery. The primary outcome is the prevalence of PND in cardiac surgery patients. The secondary outcomes will be the incidence of postoperative delirium, pain, sleep quality, depressive symptoms, activities of daily living, length of hospital stay and ICU length of stay, and rate of complication and mortality during the hospital stay. Ethics and dissemination: Beijing Chaoyang Hospital Ethics Committee approved this study and has number 2022-ke-487. It is registered with Clinical Trials (trial number NCT 05668559). Informed consent must be provided by all participants. The study result will be published in a peer-reviewed journal. Trial registration number: NCT05668559
Apoptosis Triggering in Breast Cancer Cells with Co-delivery of Melatonin and Doxorubicin Loaded into Human Adipose Mesenchymal Stem Cell Derived Exosomes
Authors: Shirzad Moein , Daraei Abdolreza , Najafzadehvarzi Hossein , Farnoush Nazila , Parsian Hadi 
Published: April 2024

Abstract
Background
In recent years, numerous efforts have been dedicated to reducing the side effects of doxorubicin (DOX). Exosomes (EXOs), as extracellular vesicles (EVs), can play a role in the safe transport of DOX in breast cancer treatment. The aim of this study was to alleviate the adverse effects associated with DOX while enhancing its targeted delivery to cancer cells through the codelivery of melatonin (MEL) as an antioxidant and DOX into EXOs-derived from human adipose tissue mesenchymal stem cells (A-MSCs).
Methods
MSCs were isolated from liposuction samples using collagenase II enzyme, and stemness markers were evaluated by flow cytometry. EXOs were extracted from conditioned A-MSCs media through ultracentrifugation, and surface markers were evaluated by western blotting, DLS and TEM. The absorption and release of EXOs in cells were investigated using PKH-26 dye and UV–Vis spectrophotometry, respectively. DOX and MEL were loaded into EXOs using the sonication method, and their cytotoxic effects on normal and cancer cells were evaluated using the MTT test. Additionally, the expression of p53, NANOG, and miR-34a genes was analyzed using qRT-PCR, and apoptosis was assessed using flow cytometry and acridine/orange dye.
Results
It was observed that they exhibited remarkable stability under pH ~ 7.4 while displaying a high release rate under low pH conditions commonly found within cancerous environments (pH ~ 5.0). Cellular uptake experiments revealed a substantial percentage of internalization. Cytotoxicity evaluation demonstrated that co-delivery of DOX and MEL into EXOs (Exo-DOX-MEL) enhanced their toxicity towards normal MCF-10A and A-MSC cells, while exhibiting greater lethality towards MCF-7 and MDA-MB231 cancer cells. In normal cells, Exo-DOX-MEL augmented the effects of DOX, leading to increased expression of p53 and miR-34a and decreased expression of NANOG, particularly in MCF-7 and MDA-MB231 cells. Apoptotic analysis validated the favorable outcomes associated with Exo-DOX-MEL, which enhanced DOX efficacy in cancer cells while reducing apoptosis in normal cells compared to the administration of free DOX.
Conclusions
Exo-DOX-MEL appears to enhance the destructive effects of DOX in cancer cells, particularly those resistant to chemotherapy such as MDA-MB231 cells. It also plays a protective role in normal cells, which could be crucial in the treatment of drug resistance and the side effects caused by DOX.
Large contribution of the sea-ice zone to Southern Ocean carbon export revealed by BGC-Argo floats
Authors: Liniger Guillaume , Moreau Sébastien , Lannuzel Delphine , Strutton Peter 
Published: April 2024

Abstract
The Southern Ocean (south of 30°S) contributes significantly to global ocean carbon uptake through the solubility pump and phytoplankton productivity. Many studies have estimated carbon export to the deep ocean, but very few have attempted a basin-scale perspective. In this study, we use an extensive array of BGC-Argo floats to improve previous estimates of carbon export across basins and frontal zones, with a focus on the sea-ice zone (SIZ). We find that the SIZ contributes 33% of the 5.08 PgC y− 1 total Southern Ocean carbon export. We also show that subsurface carbon respiration, not flux out of the surface ocean, contributes most strongly to the temporal and spatial variability of carbon export. Our work highlights the importance of closely monitoring the SIZ to accurately quantify the total Southern Ocean carbon sink, especially as the SIZ is prone to strong interannual variability. Tightening these estimates and their drivers ultimately impacts our understanding of climate variability at the global ocean scale.
Highly Efficient Degradation of Methyl Orange by g-C3N4 Nanosheets Doped with Noble Metal Silver Under Simulated Sunlight
Authors: Zhang SiYu , Zhu HuaYing , Sun JiaLing , Lin Chunling , Xue Dan , Lu Xingyu 
Published: April 2024

Abstract
Photocatalytic technologies capable of using solar energy for environmental restoration have much progressed with the increasing environmental concern.In this investigation,novel Ag@g-C3N4 nanocomposite was synthesized by thermal polycondensation and simple liquid phase reduction method with g-C3N4 using melamine and urea as nitrogen sources. A series of characterization for Ag@g-C3N4 nanocomposites was carried out by X-ray polycrystalline diffraction electron microscopy、UV diffuse reflection and Physical adsorption. The electrochemical properties of the composite materials were studied by open circuit potential and AC impedance. The technolgy for degradation of methyl orange solution stimulated waste water was studied, the best conditions of processing were obtained: The Ag@g-C3N4 nanocomposites concentration of which is 0.2 g/L,the of the volume of 30% H2O2 was 30 ml/L and time of degradation was 3h. The study revealed that the catalysts prepared have optical light-absorbing property, high surface area, and stability. The results were shown that g-C3N4@Ag nanocomposite can effectively inhibit the recombination of photogenerated electrons and holes, and their electron transfer ability and photocatalytic characteristics are better than g-C3N4 nanosheets for novel metal Ag. Most notably, with preserved reactivities, this heterogeneous Ag@g-C3N4 composite can be used at least 5 times. Advantages of this method are green solvent, mild condition and reusable catalyst.
Developing a quality indicator framework for One Stop Crisis Centre (OSCC) services in Malaysia: A study protocol
Authors: Oon Siti Waringin , Oon Siti Waringin , Rahman Nik Hisamuddin Nik Abd , Yaacob Normalinda 
Published: April 2024

Abstract
Background
Assessing the quality of care especially for One Stop Crisis Centre (OSCC) services has become increasingly important due to the demand for OSCC services increasing each year. In addition, the OSCC has been established in Malaysia since 1994 but until today there is no mechanism for monitoring processes to be developed and it is timely to assess their services properly. This study aims to develop the quality indicators (QI) framework for OSCC services in Malaysia.
Methods
This study will use the design and development research technique and the protocol will be conducted in three phases: Phase 1 for need analysis, Phase 2 for design and development of QI, and Phase 3 for the validation and usability process.
The subjects of this study will involve experts in OSCC services including healthcare providers (doctors, nurses, medical social workers), police officers, social welfare officers, and non-governmental organization (NGO) personnel. Fifty respondents from various groups will be recruited in this study.
Discussion
The QIs developed through this study will be evidence-based and balanced across the areas of structures, processes and outcomes. The rigorous methodology used to develop and test the QI framework will result in QIs that are meaningful, valid, feasible to collect and efficiently measurable, amenable to improvement, and selected by experts in OSCC services. The final QI framework can support comparison, benchmarking and optimization for OSCCs to provide the best services for their clients.
Computing psycholinguistic analysis by examining topic modelling and sentiment analysis during COVID-19: changes in wording and emotions for public health
Authors: Figueiredo Sandra 
Published: April 2024

Abstract

Between 2020 and 2022, lockdown and restraining measures as a result of the COVID-19 pandemic led to changes in daily routines and also in language usage. At certain points during the pandemic, populations in some countries were unwilling or unlikely to respond to government messages, either because of the tone and analytic discourse used by leaders, or because they did not understand the messages. Linguistic markers and meanings were therefore linked to low levels of engagement, negative emotions and high levels of analytical thinking, especially in relation to the discourses of influential global speakers. We subjected sixteen speeches by eight country leaders to topic modelling and sentiment analysis in order to understand how the psychological functions of language were affected during two different periods of the COVID-19 pandemic. In this topic analysis we organize 39,073 words collected from sixteen authentic speeches delivered in two different periods of the acute phase of the pandemic. These were encoded in the Linguistic Inquiry Word Count program (LIWC), with the main aim being to identify differences between the periods. We examined the following aspects: (1) the emotional tone, analytical thinking and clout (empathy dimension); (2) the changes in these three dimensions or factors between periods 1 and 2 (February and May 2020). We observed a negative relationship between emotional tone and analytical thinking and a positive relationship between clout and emotional tone. When we considered the changes in pandemic circumstances, the psycholinguistic profiles of eight country leaders demonstrated fluctuations in language and emotions. Further reviews and research should focus on the current language and deficit wording of this population (leaders). We also note that psychologists and schoolteachers can play an important role in supporting language programmes with positive wording and by emphasising the collateral effects of face-to-face classes when teaching children to read and write.
Will ‘o the Wisps: non-traditional data to inform modern science
Authors: Miner Kimberley , Wong Ethan , Gay Bradley , Miller Charles 
Published: April 2024

Abstract
The modern climate is changing faster and on larger spatial scales than ever in human history. Though the modern instrument-based record of Earth observations reflects decades of critical work, multi-century time series may be required to understand and forecast key elements of Earth system dynamics. Here, we explore the utility of non-traditional climate data records – observations reported without using modern instruments or standardized measurement protocols – to illuminate important patterns of climate change that predate modern methodologies and tools. We compile a list of diverse datasets collected during the past 500 years including landscape paintings, sea lore, and fish haul data. This initial review and analysis present novel possibilities for scientists across regions and disciplines to reconstruct past climate in ways that complement more traditional methods.
Theoretical and Numerical Analyses of Multilayer Left-handed Metamaterial Optical Waveguide Structure with a Localized Arbitrary Kerr-type Nonlinear Guiding Film
Authors: Wu Yaw-Dong , Xu Yi-Jun 
Published: April 2024

Abstract

We propose theoretical and numerical analyses of multilayer left-handed metamaterial (LHM) optical waveguide structures with a localized arbitrary Kerr-type nonlinear guiding film. To the best of our knowledge, the proposed method has not been reported before. It gives detailed modal analyses of TE-polarized waves in the proposed photonic metamaterial slab optical waveguide structures. The analytical results are accompanied by some numerical examples. The method can also be degenerated to analyze planar conventional optical waveguide structures with a localized arbitrary Kerr-type nonlinear guiding film. It can also help researchers to calculate the evolutions of TE waves propagating in the proposed waveguide structures. Based on this method, the analysis and calculation of planar LHM multilayer slab optical waveguide structure with a localized arbitrary Kerr-type nonlinear guiding film and planar conventional multilayer slab optical waveguide structure with a localized arbitrary Kerr-type nonlinear guiding film can be achieved easily.
Groundwater Potential Assessment Using Integrated 2D and 3D Electrical Tomography and 2D Gravity Modeling: A Case of Burka Uke Catchment, West Ethiopia
Authors: Adugna Imiru , Lamessa Geremew 
Published: April 2024

Abstract

Uke Town's expanding infrastructure and growing population necessitate a larger water supply for agricultural and drinking uses. As a result, the goal of the research is to map the aquifer in the Burka Uke catchment in West Ethiopia by determining the depth of the basement rocks, the resistivity and density of subsurface layers, their thickness, and the structural components. In order to identify the potential for groundwater and the structural components that regulate the geometry of groundwater aquifers in the region, the study combines integrated electrical resistivity tomography with gravity modeling. Low resistivity variation in the subsurface is revealed by the resistivity profile studies (1, 4, and 6), suggesting the existence of possible groundwater aquifers. The stark difference in resistivity values between 498 and 1612 ohm.m. is thought to indicate a high fracture density, which could indicate the presence of geological structures that could support the buildup of groundwater. Additionally, the entire Bouguer gravity anomaly image, which is separated into regional and residual components, displays values ranging from 51.79 to 41.59 mGal. Fault elements have been identified using the residual gravity anomaly map; fault elements that strike from south to north have been mapped in this study. Furthermore, the outcomes of 2D and 3D electrical tomography as well as 2D gravity modeling along B-B' show that the aquifer extends far across the research area in a North-South direction.
Interleukin-15-armored GPC3-CAR T cells for patients with solid cancers
Authors: Heczey Andras , Steffin David , Ghatwai Nisha , Montalbano Antonino , Rathi Purva , Courtney Amy , Arnett Azlann , Fleurence Julien , Sweidan Ramy , wang tao , Zhang Huimin , Masand Prakash , Maris John , Martinez Dan , Pogoriler Jennier , Varadarajan Navin , Thakkar Sachin , Lyon Deborah , Lapteva Natasha , Zhuyong Mei , Patel Kalyani , Lopez-Terrada Dolores , Ramos Carlos , Lulla Premal , Armaghany Tannaz , Grilley Bambi , Dotti Gianpietro , Metelitsa Leonid , Heslop Helen , Brenner Malcolm , Sumazin Pavel 
Published: April 2024

Abstract

Interleukin-15 (IL15) promotes the survival of T lymphocytes and enhances the antitumor properties of CAR T cells in preclinical models of solid neoplasms in which CAR T cells have limited efficacy1-4. Glypican-3 (GPC3) is expressed in a group of solid cancers5-10, and here we report the first evaluation in humans of the effects of IL15 co-expression on GPC3-CAR T cells. Cohort 1 patients (NCT02905188/NCT02932956) received GPC3-CAR T cells, which were safe but produced no objective antitumor responses and reached peak expansion at two weeks. Cohort 2 patients (NCT05103631/NCT04377932) received GPC3-CAR T cells that co-expressed IL15 (15.CAR), which mediated significantly increased cell expansion and induced a disease control rate of 66% and antitumor response rate of 33%. Infusion of 15.CAR T cells was associated with increased incidence of cytokine release syndrome, which was rapidly ameliorated by activation of the inducible caspase 9 safety switch. Compared to non-responders, tumor-infiltrating 15.CAR T cells from responders showed repression of SWI/SNF epigenetic regulators and upregulation of FOS and JUN family members as well as genes related to type I interferon signaling. Collectively, these results demonstrate that IL15 increases the expansion, intratumoral survival, and antitumor activity of GPC3-CAR T cells in patients.
Do randomised clinical trials on dental caries adopt Open Science Practices?
Authors: Acosta Carolina P. , Cenci Jaisson , Brondani Bruna , Elagami Rokaia A. , Pereira-Cenci Tatiana , Cenci Maximiliano S. , Huysmans Marie-Charlotte D. N. J. M. , Raggio Daniela P. , Braga Mariana M. , Mendes Fausto Medeiros 
Published: April 2024

Abstract

Background
Open Science Practices (OSPs) are essential when assessing research integrity and quality of Randomised Clinical Trials (RCTs). As dental caries represents a significant oral health burden, our objective was to identify and analyse the adoption of OSPs within RCTs focused on addressing this disease.
Methods
We searched PubMed to retrieve RCTs related to dental caries published from 2000 to March 2022. Two independent researchers assessed a random sample of these manuscripts to evaluate their eligibility until reaching the minimum sample size. Then, the same examiners reviewed the included texts regarding the OSPs adopted in the manuscripts. The collected variables related to OSPs were reporting guidelines, protocol registration, detailed methodology available, open-source software, statistical analysis code sharing, statistical analysis plan, data sharing, open peer review, and open access. Association analyses using logistic regression were conducted considering the publication year, the continent of the first author, impact factor and open-access policy of the journals (explanatory variables), and adoption of at least one OSP or one OSP other than open access (outcomes). The recommendations for adopting OSPs were assessed by reviewing the “Instructions for Authors” section of the most frequently used journals where the included papers were published.
Results
64.8% of the manuscripts (95% Confidence Interval = 59.3–70.1%) adopted at least one OSP. However, no individual OSP was adopted by more than 50% of the manuscripts. The most adopted practices were protocol registration (37.1%), the use of reporting guidelines (33.1%) and publishing open access (37.3%). These are also the OSPs most often recommended by journals in the Instructions for Authors. A few manuscripts adopted other practices. Older manuscripts presented a lower frequency of adopting these practices, and manuscripts published in higher impact factor journals were positively associated with both outcomes.
Conclusion
The RCTs published on dental caries demonstrate a low frequency of adoption of most OSPs. However, a trend toward increased adoption of these practices has been notable in recent years.