bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fine‐needle aspiration cytology of adrenal cryptococcosis: A case report
Authors: Powers Celeste N. , Rupp George M. , Maygarden Susan J. , Frable William J. 
Published: February 2007

AbstractA case of adrenal cryptococcosis diagnosed by fine‐needle aspiration biopsy cytology in a 58‐yr‐old man is presented. The organisms were easily seen with routine modified Wright stain (Diff‐Quik) as variably sized yeasts, some with a brightly eosinophilic capsule. The diagnosis was confirmed with mucicarmine and silver stains. The identification of fungi with routine cytologic stains allows a rapid presumptive diagnosis of the infectious agent, collection of material for confirmatory special stains, and prompt initiation of therapy.
Diagnosis of cutaneous leishmaniasis by fine‐needle aspiration biopsy: Report of a case
Authors: Akhtar Mohammed , Bakry Mohammed , Qadri S. M. Hussain , Ali Muhammad Ashraf 
Published: February 2007

AbstractA case of cutaneous leishmaniasis diagnosed by fine‐needle aspiration biopsy is presented. The cytologic smears revealed lymphocytes, plasma cells, and macrophages. Large numbers of Leishmania organisms were present within the macrophages and in the intercellular spaces. Part of the material was used for a microbiologic culture, which revealed large numbers of promastigotes. These were studied by light, transmission, and scanning electron microscopy.
Detection of Chlamydia Trachomatis in papanicolaou‐stained cervical smears: Control study by in situ hybridization
Authors: Ghirardini Carla , Ghinosi Patrizia , Raisi Orville , Rivasi Francesco , Trentini Gian Paoio 
Published: February 2007

AbstractNinety‐one Papanicolaou‐stained vaginopancervical smears were destained and subjected to in situ hybridization with Chlamydia trachomatis DNA probe. At cytologic examination (Pap test), 71 smears showed changes suggestive of chlamydial infection, while remaining 20 were negative. At the control by in situ hybridization, the results of Pap test were confirmed in 85 out of 91 cases, two false‐positive and four false‐negative cases being detected. The sensitivity and specifcity of Pap test, compared with in situ hybridization, were 95% and 89%, respectively. Like some recent reports, the present study confirms the reliability of Pap test in the detection of Chlamydia trachomatis and its possible relevant role in reducing the diffusion of the infection, when properly applied to mass‐screening program.
Fine‐needle aspiration cytology of alveolar soft‐part sarcoma
Authors: Shabb Nina , Sneige Nour , Fanning Christina V. , Dekmezian Roupen 
Published: February 2007

AbstractAlveolar soft‐part sarcoma (ASPS) is a rare soft‐tissue tumor. Few cases have been reported in the aspiration cytology literature. We discuss the fine‐needle aspiration (FNA) cytologic features of ASPS in four patients. The smears were characterized by single cells and clusters of cells associated with thin‐walled vasculature, resulting in a distinct pseudoalveolar pattern. The cells had abundant granular cytoplasm and large round nuclei with prominent central nucleoli. Binucleated and occasional multinucleated cells were present. Numerous stripped tumor nuclei were a consistent feature. Periodic acid‐Schiff (PAS)‐positive diastase‐resistant granules were demonstrable within the intact and fragmented cytoplasm. Electron microscopy of aspirated material identified granules and crystals with the characteristic lattice pattern. To conclude, the FNA cytologic features of ASPS are characteristic. Confirmation by special stains and electron microscopy of FNA material is possible. The differential diagnostic considerations include renal cell carcinoma, paraganglioma, granular cell tumor, clear cell sarcoma, and epithelioid sarcoma.
Occult thyroid cancer discovered by fine‐needle aspiration cytology of cervical lymph node: A report of three cases
Authors: Matsuda Minoru , Nagumo Sachiko , Koyama Hiroki , Wada Akira 
Published: February 2007

AbstractThree cases of occult thyroid cancer measuring 10, 6, and 3 mm in diameter were discovered by fine‐needle aspiration cytology of cervical lymph nodes. In these three cases, thyroid tumors were not palpable, and scintigraphic, echographic, and sof‐tissue radiologic examinations demonstrated no abnormalities of the thyroid glands. Cytologically, the presence of intranuclear cytoplasmic inclusions, nuclear grooves, and colloid was characteristic in aspirated materials. Histologically, all three cases were diagnosed as papillary carcinoma. Fine‐needle aspiration cytology of cervical lymph node was very useful to find occult carcinoma of the thyroid gland.
Usefulness of a near‐total fine‐needle aspiration biopsy retrieval method: A study of its use in 85 consecutive patients
Authors: Dekker Andrew , Reyna Etna L. , Fuhrman Carl 
Published: February 2007

AbstractFine‐needle aspiration biopsy may provide miniscule material for diagnosis. A method was devised to ensure optimal retrieval of the specimen. If performed in the manner described, at least four to five different samples from each case may be obtained. This includes a smear stained with the Papanicolaou and hematoxylin and eosin methods, a cell block preparation, and at least two cytocentrifuge specimens. In 85 cases in which the method was applied and subsequently analyzed, we found the cell block and Papanicolaou‐stained smears to be most effective for diagnosis, whereas the cytocentrifuge method was much less effective. The sensitivity and specificity were 93% and 100%, respectively.
Fine‐needle aspiration cytology and the diagnosis of neoplasms in the pediatric age group
Authors: Layfield Lester J. , Glasgow Ben , Ostrzega Nora , Reynolds C. Patrick 
Published: February 2007

AbstractSixty‐six aspirates obtained from 63 pediatric patients clinically suspected of having small cell malignancies were studied by a variety of techniques to determine the accuracy and utility of fine‐needle aspiration (FNA) in the diagnosis of small round‐cell neoplasms (SRCN) of childhood. FNA correctly identified all 47 SRCNs as malignant and gave a correct specific diagnosis in 81% of the cases. No false‐positive diagnoses of malignancy occurred in this series. Electron microscopy, immunohistochemistry, and cell culture performed on FNA material were found to be useful aids in the diperential diagnosis of these tumors. The cytologic appearances and differential diagnoses of these neoplasms are discussed.
Diagnostic utility of fine‐needle sampling without aspiration: A prospective study
Authors: Rajasekhar Angajala , Sundaram Challa , Chowdhary Thomas , Charanpal Motupalli , Ratnakar K. S. 
Published: February 2007

AbstractFine‐needle sampling without aspiration (FNS) was done in 100 consecutive patients with 109 palpable masses. Its effciency in obtaining adequate material is compared with conventional fineneedle aspiration cytology (FNAC) and found to be 80% with either method. FNS shows a diagnostic accuracy that correlates well with FNAC and histopathology. Malignant lesions are sampled more easily. Anatomic site has no influence on the yield. Most of the negative cases are small swellings, less than 1.5 cm in diameter. It is more cost effective than FNAC. Trauma to the tissues and the resultant artifacts are less. It is relatively painless and can safely be applied to many areas, including some sensitive sites.
Fine‐needle aspiration cytology in the diagnosis of cysticercosis presenting as palpable nodules
Authors: Rajwanshi A. , Radhika S. , Das A. , Jayaram N. , Banerjee C. K. 
Published: February 2007

AbstractThe cytologic findings in the fine‐needle aspirate of 30 cases of cysticercosis presenting as palpable nodules are described. Essential for a diagnosis are identification of parasitic fragments. These include bluish fibrillary structures sometimes with honeycombing, tegument of parasite thrown into rounded wavy folds, and scolex with hooklets and hyaline membrane surrounding it. The inflammatory reaction consisted of eosinophils, neutrophils, lymphocytes, histiocytes, epithelioid cells, and giant cells in varying proportions.
Cerebrospinal fluid pleocytosis in aseptic meningitis: Cytomorphic and lmmunocytochemical features
Authors: Ross Jeffrey S. , Magro Cynthia , Szyfelbein Wanda , Sorensen Susan 
Published: February 2007

AbstractWe report five cases of aseptic meningitis presenting with high cerebrospinal fluid (CSF)cell counts (260‐600 cells/cmm) and mononuclear pleocytosis, suggesting the diagnosis of CNS malignant lymphoma. In four of five cases a reactive background of small lymphocytes, monocytes, and eosinophils was seen. Immunocytochemical studies in all five cases revealed that 100% of the lymphoid cells were T‐cells. Three of four cases evaluated for lymphocyte subsets displayed a CD4 to CD8 ratio of 3:1. In the fourth case the CD4:CD8 was 1 to greater than 10; this patient was subsequently proven to have AIDS with HIV meningitis. In this study the cytologic features of the benign atypical lymphoid pleocytosis of aseptic meningitis in contrast to malignant lymphomas in CSF specimens included small or indistinct nucleolus, regular perinucleolar area, smaller widely separated chromatin aggregates, generally ample cytoplasm with perinuclear clearing and polyclonal T‐cell immunophenotype.
A model for quantitative follow‐up studies of cervical lesions
Authors: Zeppa P. , Van der Poel H. G. , Boon M. E. , Kok L. P. , Kurniawan A. N. 
Published: February 2007

AbstractA model for follow‐up studies of cervical lesions is described in which the specimen were taken in a noninvasive way using Cytobrushes and in which automatic measurement of the abnormal nuclei in the sampled epithelial fragments was possible because 2‐μm thin Feulgen‐stained plastic sections were prepared. The planimetric parameters AREA, PERIMETER, FORM PE, and FORM ELL, and the densitometric parameters optical density (OD) and integrated optical density (IOD) were assessed. The mean total volume and the mean total DNA were calculated using stereological methods. The moderate dysplasias differed from the carcinoma in situs for all the densitometric parameters except for OD, and from the invasive carcinomas for IOD and 5cER. In the moderate‐dysplasia group, there were three types of DNA histograms: a highly abnormal type resembling the histograms of the carcinoma group, a normal type, and an intermediate type. Changes in DNA histograms can be established during follow‐up studies of dysplasias without having disturbed the lesion due to the efficient and elegant noninvasive sampling method that was not used in earlier quantitative studies.
Diagnostic correlation of fiberoptic bronchoscopic biopsy and bronchoscopic cytology performed simultaneously
Authors: Naryshkin Sonya , Daniels Joan , Young Nancy A. 
Published: February 2007

AbstractThe reliability of bronchoscopic cytology relative to biopsy is controversial. Some still consider biopsy the definitive procedure. Comparative studies are few and limited in scope. Therefore, we compared simultaneously obtained biopsies and cytologies for 224 cases. One hundred and sixty‐six cases (74.6%) correlated completely. Forty‐four cases (19.6%) did not correlate and cytology was diagnostic in 24 of these. Biopsy was diagnostic in sarcoidosis and vasculitis, whereas cytology only excluded the presence of neoplasm or infection. In 14 cases (5.8%), biopsy and cytology showed pathologic changes, but one or the other was more definitive. Rarely, the 2 techniques provided complementary information. A specific diagnosis was obtained more often from the combination of cytology and biopsy than from either alone. However, when biopsy is contraindicated it is reassuring that cytology usually yields the same information as biopsy, and can detect neoplastic and infectious diseases when the biopsy is non‐diagnostic. © 1992 Wiley‐Liss, Inc.
Superficial and deep‐seated tuberculous lesions: Fine‐needle aspiration cytology diagnosis of 574 cases
Authors: Das Dilip K. , Bhambhani Suresh , Pant Jiwa N. , Parkash Suraj , Murthy N. S. , Hedau Suresh T. , Sodhani Pushpa , Pant Chandra S. 
Published: February 2007

AbstractOver a period of 2 yr (1987‐1988), FNA smears in 574 cases were found to have cytologic features suggestive of or consistent with tuberculous lesions. The age of the patients ranged from 6 mo to 75 ye, with a median of 24 yr. The male to female ratio was 273:301. Sites of FNA were superficial lymph nodes (SLN) in 440 (76.7 percent) cases, superficial extranodal sites (SENS) in 50 (8.7 percent), both SLN and SENS in 7 (1.2%), the thoracic cavity in 16 (2.8%), and the abdominal cavity in 61 (10.6%). Cytologic features were described under 3 major cytologic patterns, i.e., type I: epithelioid granuloma without necrosis, type II: epithelioid granuloma with necrosis, type III: necrosis without epithelioid granuloma. Type I, II, and III reactions were observed in 181 (31.5%), 183 (31.9%), and 210 (36.6%) cases, respectively. The overall AFB positivity was 30.8%. The AFB positivities for type I, II, and III cytologic reactions were 5.4%, 32.0%, and 48.5%, respectively. The AFB positivity was tow (< 30.0%) in swellings of the body surface (23.8%) and abdominal organs (18.9%). High positivity (> 60.0%) was observed in lesions of the thorax (63.6%) and thyroid (62.5%). © 1992 Wiley‐Liss, Inc.
Urothelial toxicity following conditioning therapy in bone marrow transplantation and bladder cancer: Morphologic and morphometric comparison by exfoliative urinary cytology
Authors: Stella Francesco , Battistelli Serafina , Marcheggiani Francesco , De Santis Maurizio , Donnorso Raffaele Perrone , Baronciani Donatella , Durazzi Suzy M. T. , Troccoli Rosario , Lucarelli Guido 
Published: February 2007

AbstractSince cyclophosphamide and busulphan used for therapy of bone marrow transplantation (BMT) can cause urothelial cell changes similar to those found in bladder cancer, comparative morphologic and morphometric urinary cytologic research was carried out, examining 812 urine samples taken from 121 patients undergoing BMT and 60 urine samples from 20 patients with bladder cancer. The morphological results showed some differences in the characteristics of the urinary sediment in urothelial toxicity caused by conditioning therapy in BMT and in bladder cancer; among these were background, cellularity, leukocytes, urothelial cell arrangement, cell shape and size, vacuolization, mitosis, and nucleoli. A comparative morphometric study was also carried out, showing differences regarding cell area, nuclear area and perimeter, and N/C ratio, especially between well‐differentiated bladder cancer and urothelial toxicity. © 1992 Wiley‐Liss, Inc.
Isolated or phagocytosed miniature dyskeratotic cells in papilloma virus infection associated with cervical neoplasia
Authors: de Borges Rosa J. , Montes America 
Published: February 2007

AbstractDyskeratotic cells that occur in squamous cervical epithelium under certain abnormal conditions appear in cervical smears in sheets or aggregates, or as miniature cells, either isolated or phagocytosed. In order to determine the tissue correlates of such cells, 116 cervical biopsies with a histopathologic diagnosis of papillomavirus (HPV) infection were reviewed and compared to previous findings in cytological smears; the patients were 18‐65 yr of age. Eighty of the 116 cases had, in addition, cervical intra‐epithelial neoplasia (CIN). A much higher number of miniature dyskeratotic cells was recorded in the biopsies from patients with both HPV and CIN types of lesions (76.3% of the biopsies had isolated miniature cells and 41.3% showed phagocytosed miniature cells), compared to those with only HPV infection (19.4% with isolated and 5.5% with phagocytosed miniature cells). In addition, in the HPV plus CIN patients, the more advanced the neoplastic lesion, the higher the percentage of cases in which both types of dyskeratocytes are observed. These highly keratinized isolated miniature cells are found in, and are considered to arise from, the deeper layers of the epithelium; when phagocytosed they appear in the center of a concentric arrangement of cells. These cells constitute a pathological entity that can be distinguished from the sheets and aggregates of dyskeratotic cells that come from the superficial layers of parakeratotic epithelia. © 1992 Wiley‐Liss. Inc.
Fine‐needle cytology of an eccrine spiradenoma of the breast: Diagnosis made by a holistic approach
Authors: Madeleine M. C. , Bosch M. A. , Boon Mathilde E. 
Published: February 2007

AbstractEccrine spiradenoma is a rather rare adnexal tumor of the skin. When the clinical presentation is that of a breast neoplasm, diagnosis can be difficult. As cytology was a new procedure for this tumor, the approach of choice appeared to be a holistic one. The cytologic picture showed bland groups of uniformly sized cuboid cells with scant cytoplasm, round to ovoid nuclei, and inconspicuous nucleoli, while in the groups rosettelike structures could be discerned. Only by integrating the data of clinical history, inspection, palpation, reaction on breast puncture, and immunologic findings could the diagnosis be made.
Cytodiagnosis of lesions presenting as salivary gland swellings: A report of seven cases
Authors: Chan May K. M. , McGuire Lloyd J. 
Published: February 2007

AbstractThe cytologic and histologic findings of seven cases presenting clinically as salivary gland swellings are described. These included two cases of pilomatrixoma of skin in the parotid region, two cases of neurilemmoma in the submandibular area, a case of Kimura's disease in the peri‐mandibular gland lymphoid tissue, a case of Castleman's disease in intraparotid lymph node, and a case of branchial cleft cyst in the parotid region. It is important to recognize lesions that masquerade as salivary gland tumors so that misdiagnosis and overdiagnosis on smears can be avoided and the patients can be treated appropriately. © 1992 Wiley‐Liss, Inc.
Aspiration biopsy cytology of papillary carcinoma of the breast
Authors: Nguyen Gia‐Khanh , Redburn Jim 
Published: February 2007

AbstractThe fine‐needle aspirates of two cases of noninfiltrating papillary carcinoma (PC) and three examples of early invasive PC of the breast were examined. In three cases in which the tumors displayed cuboidal or polygonal cells the aspirates showed papillalike clusters of tumor cells with relatively “strong” cellular cohesiveness. Single and small aggregates of tumor cells as well as hemosiderin‐laden or foamy macrophages were also present. Aspirates from the two PCs predominantly consisting of tall columnar epithelial cells revealed only monolayered and multilayered epithelial fragments with folding in one case. In the other case large epithelial fragments and small tight clusters of polygonal tumor cells were present. No bipolar nuclei of myoepithelial cells were identified in all cases. No specific cellular features permitting the differentiation between noninfiltrating and early invasive breast PCs were identified in this small series. Staining for carcinoembryonic antigen using the peroxidase‐antiperoxidase technique was performed on aspiration smears of three cases. It revealed a positive cytoplasmic reaction in two cases. © 1992 Wiley‐Liss, Inc.
Ovarian follicular cysts: A potential source of false positive diagnoses in ovarian cytology
Authors: Nuñez Carlos , Diaz Jose I. , Selvaggi Suzanne 
Published: February 2007

AbstractThe cytology samples of 22 benign ovarian cysts aspirated during laparoscopy (16) or laparotomy (6) were evaluated for clinicopathologic correlations. Clinically, most patients were evaluated for chronic pelvic pain. The cysts ranged in size from 1 to 5 cm (average 2.4 cm), and were described as having benign appearance. Cytologically, small granulosa cells arranged in clusters or isolated had granular cytoplasm with occasional microvacuoles. The nuclei were round to oval, uniform, and eccentrically placed. They had granular chromatin with chromocenters and one to two micronucleoli. Relative nuclear area averaged 50%. Mitoses were present in all but two cases, ranging from 0 to 38 mitoses per 10 high power fields (average 7.2 mitoses per 10 high power fields). Present in some cases were mesothelial cells and histiocytes. Three cases with follow‐up histopathology specimens revealed two follicular cysts and a collapsed cyst without discernible lining. The immature appearance of the granulosa cells, the granular chromatin, and the presence of mitoses often suggested cytologically the possibility of a neoplastic process. Recognition of the cytopathology features, knowledge of the clinical history, and the laparoscopic findings may reassure the pathologist about the benign nature of the cysts. © 1992 Wiley‐Liss, Inc.
Should we report cervical smears lacking endocervical component as unsatisfactory?
Authors: Sidawy Mary K. , Tabbara Sana O. , Silverberg Steven G. 
Published: February 2007

AbstractThe purpose of the study is to correlate the accuracy of diagnosis of cervical smears with the presence/absence of an endocervical component. The referral smears and the smears obtained during colposcopic examination of 84 patients with biopsy‐proven squamous lesions were evaluated for the presence of an endocervical component, and the cytologic interpretations were compared with the histologic findings. Of the 136 smears containing an endocervical component, 111 (81.6 percent) had good correlation with histology and 25 (18.4%) showed a discrepancy. Of the 30 smears lacking an endocervical component, 24 (80%) had good histologic correlation and 6 (20%) were discrepant. Our data showed no significant difference in the detection of squamous lesions in those smears with an endocervical component from those without. We conclude that, although the presence or absence of an endocervical component should be documented in the cytology report, its absence should not be an indication to report the cervical smears as unsatisfactory. Diagn Cylopathol 1992;8:567‐570. © 1992 Wiley‐Liss, Inc.
Testicular cytology in azoospermia
Authors: Verma Anand Kumar , Basu Debdatta , Jayaram Gita 
Published: February 2007

AbstractTwo hundred‐seventy‐five azoospermic mates were subjected to fine‐needle aspiration (FNA) cytologic study of testis with the aim of determining the cause of azoospermia; 534 aspirates from these patients were classified as follows: normal spermatogenesis (162), hypospermatogenesis (mild, moderate, or severe, 226), absence of spermatogenesis (130), maturation arrest (36), Sertoli‐cell‐only syndrome (14), and Leydig‐cell hyperplasia (3). The morphology of cells was excellent in the cytologic preparations and various spermatogenic cells and Sertoli cells were easily recognized. Leydig cells were uncommonly seen, except in cases of Leydig‐cell hyperplasia. Degenerative changes, possibly due to obstruction, were seen in 104 cases. The procedure was well tolerated by the patients. We conclude that FNA cytology is a useful investigative modality in the evaluation of azoospermic males.