bluuebunny/crossref_metadata_2025_split huggingface dataset:
1,2,4,5‐Tetraoxane derivatives/hybrids as potent antimalarial endoperoxides: Chronological advancements, structure−activity relationship (SAR) studies and future perspectives
Authors: T. A. Abdul Rahaman , Rajendra Thakar Neha , Suhas Kshirsagar Prasad , Ippagunta Sirish K. , Chaudhary Sandeep 
Published: April 2024

AbstractMalaria is a life‐threatening disease that affects tropical and subtropical regions worldwide. Various drugs were used to treat malaria, including artemisinin and derivatives, antibiotics (tetracycline, doxycycline), quinolines (chloroquine, amodiaquine), and folate antagonists (sulfadoxine and pyrimethamine). Since the malarial parasites developed drug resistance, there is a need to develop new chemical entities with high efficacy and low toxicity. In this context, 1,2,4,5‐tetraoxanes emerged as an essential scaffold and have shown promising antimalarial activity. To improve activity and overcome resistance to various antimalarial drugs; 1,2,4,5‐tetraoxanes were fused with various aryl/heteroaryl/alicyclic/spiro moieties (steroid‐based 1,2,4,5‐tetraoxanes, triazine‐based 1,2,4,5‐tetraoxanes, aminoquinoline‐based 1,2,4,5‐tetraoxanes, dispiro‐based 1,2,4,5‐tetraoxanes, piperidine‐based 1,2,4,5‐tetraoxanes and diaryl‐based 1,2,4,5‐tetraoxanes). The present review aims to focus on covering the relevant literature published during the past 30 years (1992–2022). We summarize the most significant in vitro, in vivo results and structure–activity relationship studies of 1,2,4,5‐tetraoxane‐based hybrids as antimalarial agents. The structural evolution of different hybrids can provide the framework for the future development of 1,2,4,5‐tetraoxane‐based hybrids to treat malaria.
Auriculocondylar syndrome 2 caused by a novel PLCB4 variant in a male Chinese neonate: A case report and review of the literature
Authors: Zhang Yongli , Zhao Yuwei , Dai Liying , Liu Yu , Shi Zifeng 
Published: April 2024

AbstractBackgroundAuriculocondylar syndrome (ARCND) is a rare congenital craniofacial developmental malformation syndrome of the first and second pharyngeal arches with external ear malformation at the junction between the lobe and helix, micromaxillary malformation, and mandibular condylar hypoplasia. Four subtypes of ARCND have been described so far, that is, ARCND1 (OMIM # 602483), ARCND2 (ARCND2A, OMIM # 614669; ARCND2B, OMIM # 620458), ARCND3 (OMIM # 615706), and ARCND4 (OMIM # 620457).MethodsThis study reports a case of ARCND2 resulting from a novel pathogenic variant in the PLCB4 gene, and summarizes PLCB4 gene mutation sites and phenotypes of ARCND2.ResultsThe proband, a 5‐day‐old male neonate, was referred to our hospital for respiratory distress. Micrognathia, microstomia, distinctive question mark ears, as well as mandibular condyle hypoplasia were identified. Trio‐based whole‐exome sequencing identified a novel missense variant of NM_001377142.1:c.1928C>T (NP_001364071.1:p.Ser643Phe) in the PLCB4 gene, which was predicted to impair the local structural stability with a result that the protein function might be affected. From a review of the literature, only 36 patients with PLCB4 gene mutations were retrieved.ConclusionAs with other studies examining familial cases of ARCND2, incomplete penetrance and variable expressivity were observed within different families' heterozygous mutations in PLCB4 gene. Although, motor and intellectual development are in the normal range in the vast majority of patients with ARCND2, long‐term follow‐up and assessment are still required.
Discovery of a pocket network on the domain 5 of the TrkB receptor – A potential new target in the quest for the new ligands
Authors: Antonijevic Mirjana , Sopkova‐de Oliveira Santos Jana , Dallemagne Patrick , Rochais Christophe 
Published: April 2024

AbstractThe important role that the neurotrophin tyrosine kinase receptor ‐ TrkB has in the pathogenesis of several neurodegenerative conditions such are Alzheimer's disease, Parkinson's disease, Huntington's disease, has been well described. This shouldn't be a surprise, since in the physiological conditions, once activated by brain‐derived neurotrophic factor (BDNF) and neurotrophin‐4/5 (NT‐4/5), the TrkB receptor promotes neuronal survival, differentiation and synaptic function. Considering that the natural ligands for TrkB receptor are large proteins, it is a challenge to discover small molecule capable to mimic their effects.Even though, the surface of receptor that is interacting with BDNF or NT‐4/5 is known, there was always a question which pocket and interaction is responsible for activation of it. In order to answer this challenging question, we have used molecular dynamic (MD) simulations and Pocketron algorithm which enabled us to detect, for the first time, a pocket network existing in the interacting domain (d5) of the receptor; to describe them and to see how they are communicating with each other. This new discovery gave us potential new areas on receptor that can be targeted and used for structure‐based drug design approach in the development of the new ligands.
CPEB1 induces autophagy and promotes apoptosis in ovarian granulosa cells of polycystic ovary syndrome
Authors: Xuan Feilan , Ren Yuefang , Lu Jiali , Zhou Weimei , Jin Ruiying , Chen Aixue , Ye Yongju 
Published: April 2024

AbstractInflammatory damage in ovarian granulosa cells (GCs) is a key mechanism in polycystic ovary syndrome (PCOS), cytoplasmic polyadenylation element binding protein‐1 (CPEB1) is important in inflammatory regulation, however, its role in PCOS is unclear. We aim to research the mechanism of CPEB1 in ovarian GCs in PCOS using dehydroepiandrosterone (DHEA)‐induced PCOS rat models and testosterone‐incubated GC models. The pathophysiology in PCOS rats was analyzed. Quantitative‐realtime‐PCR, TUNEL, immunohistochemistry, and Western blot were applied for quantification. Additionally, cell counting kit‐8, flow cytometry, immunofluorescence, Western blot, and Monodansylcadaverine staining were performed. We found that PCOS rat models exhibited a disrupted estrus cycle, elevated serum levels of testosterone, luteinizing hormone (LH), and follicle‐stimulating hormone (FSH), increased LH/FSH ratio, and heightened ovarian index. Furthermore, reduced corpus luteum and increased follicular cysts were observed in ovarian tissue. In ovarian tissue, autophagy and apoptosis were activated and CPEB1 was overexpressed. In vitro, CPEB1 overexpression inhibited cell viability and sirtuin‐1 (SIRT1), activated tumor necrosis factor‐α, and interleukin‐6 levels, as well as apoptosis and autophagy; however, CPEB1 knockdown had the opposite effect. In conclusion, overexpression of CPEB1 activated autophagy and apoptosis of ovarian GCs in PCOS.
#StillServing: Engaging younger veterans in continued service
Authors: Rinella Jennifer F. , Neil Merritt 
Published: April 2024

AbstractThis case study examines the Veterans of Foreign Wars (VFW) efforts over the past 3 years through #StillServing, a movement to highlight the stories and voices of veterans who continue to serve their communities in various ways, provide avenues for communities to coalesce around volunteerism, and attract younger generations for a wider range of engaged veterans. With an overarching goal to amplify the perception of the VFW as a place for dedicated veterans of all stripes to continue their service to country and their communities, the campaign spotlights men and women who exemplify the best of what it means to be a VFW member through storytelling emphasizing diversity, tenacity, and an enduring commitment to serve. Informed by findings from individual interviews conducted with a diverse group of U.S. military veterans, targeted messages with specific calls to action were developed for younger veterans. The association sought to take advantage of the most relevant and effective media to share its message while ultimately encouraging the veteran and military community to share their own stories of continued service through #StillServing. The case shares lessons learned from the campaign's iterative approach and offers creative, tested strategies for other programs seeking to engage younger generations.
Flexible High Lithium‐Ion Conducting PEO‐Based Solid Polymer Electrolyte with Liquid Plasticizers for High Performance Solid‐State Lithium Batteries
Authors: Abe Ayaka , Mori Daisuke , Wang Zhichao , Taminato Sou , Takeda Yasuo , Yamamoto Osamu , Imanishi Nobuyuki 
Published: April 2024

AbstractLithium‐ion secondary batteries (LIB) with high energy density have attracted much attention for electric vehicle (EV) applications. However, LIBs have a safety problem because these batteries contain a flammable organic electrolyte. As such, all‐solid secondary batteries that are not flammable have been extensively reported recently. In this study, we have focused on polymer electrolytes, which is flexible and is expected to address the safety problem. However, the conventional polymer electrolytes have low electrial conductivity at room temperature. Various attempts have been made to solve this problem, such as the addition of inorganic fillers and ionic liquids; however, these composite polymer electrolytes have not yet reached a practical level of lithium‐ion conductivity. In this study, high electrical conductivity and lithium dendrite formation‐free PEO based composite electrolytes are developed with both a filler of Li6,4La3Zr1.4Ta0.6O12 and liquid plasticizers of tetraethylene glycol dimethyl ether and 1,2 dimethoxyethane. The proposed flexible polymer electrolyte shows a high electrical conduciviy of 6.01×10−4 S cm−1 at 25 °C.
Study on the pyrolysis characteristics, kinetics, thermodynamics, volatile products, and chemical reactions of micron polyamide waste, a typical marine plastic microfragment
Authors: Liu Yitao , Zheng Wenfang , Wu Yueqiang , Chen Ruiyu 
Published: April 2024

AbstractThe pollution of waste plastic microfragments to the marine ecosystems is an increasingly serious problem. Pyrolysis is widely recognized as a viable technique for the treatment of such plastic waste materials. The pyrolysis behaviors, characteristic parameters, kinetics, thermodynamics, volatiles, and possible chemical reactions during the pyrolysis of micron polyamide waste (the main component of fishing gear abandoned in the marine environment) are studied in inert atmosphere in the present work. The results show that the pyrolysis of micron polyamide may be regarded as a one‐step reaction. The peak and average reaction rates decrease significantly when the heating rate increases. The calculated kinetic parameters can effectively predict the pyrolysis behaviors of micron polyamide. The pyrolysis of micron polyamide is characterized as an endothermic reaction that occurs non‐spontaneously. Furthermore, the information of volatiles was obtained. The volatiles with higher content were –CH2 groups, CO2, and lactam, and the volatiles with smaller content were: –NH groups, NH3, HCN, H2O, CO, and amide derivatives. In addition, an analysis was conducted to explore the potential chemical reactions.Highlights
The pyrolysis of micron polyamide can be considered as a one‐step reaction.
The obtained kinetic parameters can well predict the pyrolysis process.
Pyrolysis of micron polyamide is a non‐spontaneous and endothermic reaction.
Specific volatile products are determined by Fourier transform infrared and mass spectrometry.
The chemical reactions that may occur during the pyrolysis have been inferred.
Phase inversion detection in immiscible binary polymer blends via zero‐shear viscosity measurements
Authors: Versteeg Frederique A. , Mukherjee Adrivit , Picchioni Francesco , Parisi Daniele 
Published: April 2024

AbstractIn the present work, we demonstrate that zero‐shear viscosity is a sensitive rheological function to detect phase inversion in immiscible binary polymer blends characterized by a viscosity ratio larger than one. The phase inversion of poly(propylene) (PP)/low‐density poly(ethylene) (LDPE) and poly(styrene) (PS)/LDPE, at various compositions, was assessed via our novel approach. For both blends, three distinctive regions could be determined through zero‐shear viscosity measurements; the LDPE matrix, the co‐continuous phase, and the PS or PP matrix. For PP/LDPE blends, the co‐continuous structure was between 50 and 75 wt.% PP, and for PS/LDPE blends the co‐continuous structure was between 45 and 75 wt.% PS, in agreement with scanning electron microscopy analysis, empirical model predictions, and literature data.Highlights
Phase inversion revealed via viscosity measurements.
Limitations of linear viscoelastic models for immiscible blends assessed.
Versatile Approach to Self‐Assembly of Surface Modified Nanoparticles into SERS‐Active Nanoclusters
Authors: Zhang Min , Liu Jie , Li Xun , Zhao Xiaoyu , Cheng Zhiqun , Deng Tian‐Song 
Published: April 2024

AbstractA versatile method is invented to self‐assemble gold nanoparticles (GNPs) into nanoclusters (NCs) of various morphologies. By storing the particles in toluene, a highly non‐polar solvent, under conditions that ensure particle stability, the success rate of subsequent assembly can be enhanced. Additionally, conducting particle self‐assembly at a stirring speed of 200 rpm allows the NCs to maintain a spherical shape. The relative standard deviation (RSD) of Raman spectral peaks of multiple NCs used as surface‐enhanced Raman spectroscopy (SERS) substrates is calculated to be less than 10%, effectively addressing the issue of low repeatability when using NCs as SERS substrates. Furthermore, even at an analyte concentration reduced to 10−9 m, a SERS characteristic peak intensity of approximately 2 × 103 is measurable, demonstrating the high sensitivity of the assembled structures. Finally, by detecting SERS signals from NCs of varying sizes, the intensities of characteristic peaks tend to converge, eliminating the influence of morphology and size on SERS detection.
Light intensity differentially mediates the life cycle of lepidopteran leaf feeders and stem borers
Authors: Xu Ting‐Ting , Wu Xian , Luo Zhen‐Bao , Tang Liang‐De , Gao Jun‐Yi , Zang Lian‐Sheng 
Published: April 2024

AbstractBACKGROUNDLeaf feeders, such as Spodoptera frugiperda and Spodoptera litura, and stem borers Ostrinia furnacalis and Chilo suppressalis, occupy two different niches and are well adapted to their particular environments. Borer larvae burrow and inhabit the interior of stems, which are relatively dark. By contrast, the larvae of leaf feeders are exposed to sunlight during feeding. We therefore designed series of experiments to evaluate the effect of light intensity (0, 2000, and 10 000 lx) on these pests with different feeding modes.RESULTSThe development of all four pests was significantly delayed at 0 lx. Importantly, light intensity affected the development of both male and female larvae of borers, but only significantly affected male larvae of leaf feeders. Furthermore, the proportion of female offspring of leaf feeders increased with increasing light intensity (S. frugiperda: 33.89%, 42.26%, 57.41%; S. litura: 38.90%, 51.75%, 65.08%), but no significant differences were found in stem borers. This research also revealed that the survival rate of female leaf feeders did not vary across light intensities, but that of males decreased with increasing light intensity (S. frugiperda: 97.78%, 85.86%, 61.21%; S. litura: 95.83%, 73.54%, 58.99%).CONCLUSIONThese results improve our understanding of how light intensity affects sex differences in important lepidopteran pests occupying different feeding niches and their ecological interactions with abiotic factors in agroecosystems. © 2024 Society of Chemical Industry.
Electrospinning in Food Packaging: Current Trend and Future Direction
Authors: Al‐Attabi Abduladheem , Ahmed Abdulrahman T. , Merza Muna S. , Shakier Hussein Ghafel , Zabibah Rahman S. , Al‐Hetty Hussein Riyadh Abdul Kareem , Baher Hala 
Published: April 2024

ABSTRACTFood packaging is a multidisciplinary field that includes food science, chemistry, engineering materials sciences and microbiology. Food packaging has sparked great interest in protecting the freshness and quality of foods and their raw materials from oxidation and microbial spoilage. Nanotechnology, especially electrospinning, has shown promising results in fabricating sophisticated food packaging materials. The current paper aims to review, highlight, discuss and challenge the latest electrospun food packaging studies. We will not only summarize the studies but also challenge the applied methods, materials and results. Moreover, we offer a more practical point of view regarding the industrial translation of electrospun food packaging.
Experience of people living with leprosy at leprosy settlements in Nigeria
Authors: Oke Gabriel Ilerioluwa , Nsofor Ifeanyi , Abubakar Bashar , Lucero‐Prisno Don Eliseo , Sunday Ademola Peter , Dibia Ernesto Oluwafemi , Elebesunu Emmanuel Ebuka , Okpokpo Obadiah , Obeta Odinaka Kingsley , Babatunde Abdulhammed Opeyemi , Adeyemi Adebowale Sylvester , Adeoye Philip Adewale , Utaka Edith Nnenna 
Published: April 2024

AbstractBackgroundAlthough Nigeria achieved the national leprosy elimination target of less than 1/10,000 population in 1998, factors such as culture, behavioural patterns and social determinants, among others, continue to contribute to an increase in leprosy cases and a poor state of living for individuals with leprosy in Nigeria. This study delves into the experiences of individuals residing in leprosy settlements in Nigeria.MethodsThis study employed a community‐based cross‐sectional design, utilizing a concurrent mixed‐methods approach for comprehensive data collection. Questionnaires, focus groups and interviews are conducted simultaneously. The research involves participants from seven leprosy communities across Nigeria's six geopolitical zones and Federal Capital Territory. Qualitative methods, including 14 focus group discussions and 6 key informant interviews, are complemented by quantitative questionnaires, engaging residents, leaders and nongovernmental organization (NGO) representatives. Respondents comprised 35 leprosy patients, 21 family members, 7 community leaders, 7 settlement officers and 2 organizational heads involved in leprosy control.ResultsThe results indicate significant access to healthcare (93.7%) and interest in self‐care practices (95.2%), with a considerable proportion (74.6%) receiving free healthcare. Interview data underscore the limited government support, with NGOs and partners assuming a more substantial role. Qualitative insights from persons living with leprosy highlight financial struggles, stigmatization and substandard living conditions in settlements, exacerbated by limited government funding. This reliance on private and NGOs is further compounded by declining funding, hindering individuals’ ability to start businesses and provide self‐care.ConclusionThis study underscores the pressing need for increased government support, funding and better living conditions for individuals affected by leprosy in Nigeria. It highlights the significance of education, awareness campaigns and human rights promotion to combat stigma and enhance the quality of life for those living with leprosy. Moreover, the study advocates for the reintegration of affected individuals into their communities to foster societal inclusion and well‐being.
The meteorology of the 2019 North Queensland floods
Authors: Robinson Corey M. , Barnes Michael A. , Narsey Sugata , Reeder Michael J. 
Published: April 2024

AbstractIn January–February 2019, a monsoon low developed over northeastern Australia and brought extreme flooding to much of tropical Queensland. The European Centre for Medium Range Weather Forecasts reanalyses are used to explain the formation and severity of the event. Strong anticyclonic Rossby wave breaking to the southeast of Australia produced weak steering winds over northern Australia, and consequently the low remained nearly stationary for over a week, contributing to the extreme rainfall. Furthermore, the tropical moist margin was deformed by a series of disturbances along the monsoon trough, which drew moist maritime air over land. The event examined has much in common with the composite mean of slow‐moving potential vorticity anomalies in North Queensland, including weak background winds and heavy precipitation. An ensemble subseasonal forecast with the Australian Bureau of Meteorology's Australian Community Climate and Earth System Simulator Seasonal prediction version system 1 shows the same relationship between the background flow, the steering, and the subsequent rainfall. Hence, accurately forecasting the background winds is a prerequisite to forecasting such extreme rainfall.
Installation protocol for charge transfer dissociation mass spectrometry on ion trapping mass spectrometers
Authors: Sasiene Zachary J. , Jackson Glen P. 
Published: April 2024

AbstractRationaleCharge transfer dissociation (CTD) is a novel fragmentation technique that demonstrates enhanced structural characterization for a wide variety of molecules compared to standard fragmentation techniques like collision‐induced dissociation (CID). Alternative fragmentation techniques, such as electron transfer dissociation, electron capture dissociation, and ultraviolet photodissociation, also overcome many of the shortfalls of CID, but none of them are a silver bullet that can adequately characterize a wide variety of structures and charge states of target compounds. Given the diversity of structural classes and their occasional obstinance towards certain activation techniques, alternative fragmentation techniques are required that rely on novel or alternative modes of activation.MethodsHerein, we present a step‐by‐step protocol for the installation of CTD on a quadrupole ion trap mass spectrometer and best practices for optimizing the signal‐to‐noise ratio and acquisition times for CTD mass spectra.ResultsIn addition to two CTD installations in the Jackson laboratory, CTD has also been installed, and is currently in operation, on two 3D ion trap mass spectrometers in France: one in the laboratory of Dr. David Ropartz and Dr. Hélène Rogneaux at INRAE in Nantes, and the other in the laboratory of Dr. Jean‐Yves Salpin at Université d'Évry Val‐d'Essonne, part of the Paris‐Saclay University system.ConclusionsHere, we provide a visual protocol to help others accomplish the instrument modification.