bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reinduction Platform for Children With First Marrow Relapse of Acute Lymphoblastic Leukemia: A Children's Oncology Group Study
Authors: Raetz Elizabeth A. , Borowitz Michael J. , Devidas Meenakshi , Linda Stephen B. , Hunger Stephen P. , Winick Naomi J. , Camitta Bruce M. , Gaynon Paul S. , Carroll William L. 
Published: August 2008

Purpose Treatment of childhood relapsed acute lymphoblastic leukemia (ALL) remains a significant challenge. The goal of the Children's Oncology Group (COG) AALL01P2 study was to develop a safe and active chemotherapy reinduction platform, which could be used to evaluate novel agents in future trials. Patients and Methods One hundred twenty-four patients with ALL and first marrow relapse received three, 35-day blocks of reinduction chemotherapy: 69 with early relapse (ER; < 36 months from initial diagnosis) and 55 with late relapse (LR). Minimal residual disease (MRD) was measured by flow cytometry after each treatment block. Results Second complete remission (CR2) rates at the end of block 1 in 117 assessable patients were 68% ± 6% for ER (n = 63) and 96% ± 3% for LR (n = 54; P < .0001). Five of seven patients with T-cell ALL (T-ALL) failed to achieve CR2. Among patients in CR2, MRD greater than 0.01% was detected at the end of block 1 in 75% ± 7% of ER (n = 36) versus 51% ± 8% of LR (n = 43; P = .0375) and 12-month event-free survival was 80% ± 7% versus 58% ± 7% in MRD-negative versus positive patients (P < .0005). Blocks 2 and 3 of therapy resulted in reduction of MRD burden in 40 of 56 patients who were MRD positive after block 1. Toxicity was acceptable during all three blocks with five deaths (4%) from infections. Conclusion The AALL01P2 regimen is a tolerable and active reinduction platform, suitable for testing in combination with novel agents in B-precursor ALL. Alternative strategies are needed for T-ALL. Serial MRD measurements were feasible and prognostic of outcome.
Influence of Year of Diagnosis, Patient Age, and Sociodemographic Status on Recommending Adjuvant Radiation Treatment for Stage I Testicular Seminoma
Authors: Hoffman Karen E. , Chen Ming-Hui , Punglia Rinaa S. , Beard Clair J. , D'Amico Anthony V. 
Published: August 2008

Purpose Adjuvant radiation therapy (ART) for stage I seminoma can cause adverse late effects and alternative postorchiectomy management strategies have been developed. This study evaluated ART trends in the United States and the impact of clinical and sociodemographic factors on ART recommendations. Methods Of men diagnosed with stage I seminoma from 1990 through 2004, 3,125 were identified using the Surveillance, Epidemiology, and End Results cancer registry. A multivariable logistic regression analysis was performed to assess whether there was a significant association between diagnosis year, diagnosis age, race, county education level, region, tumor size, tumor category, and the recommendation for ART. Results There was a significant association (P < .001) between later year of diagnosis and a decrease in ART recommendation. Compared with men diagnosed in 1990 to 1994, men diagnosed in 1995 to 1999, and 2000 to 2004 were less likely to have ART (adjusted odds ratio [OR], 0.63; 95% CI, 0.48 to 0.84; and OR, 0.49; 95% CI, 0.37 to 0.63, respectively). There also was a significant association (P < .001) between county education level and ART recommendation. Men residing in counties with the highest education level were more likely to receive ART than men residing in counties with the lowest education level (OR, 2.12; 95% CI, 1.59 to 2.82). Also, men older than 30 years were more likely to receive ART than men age 30 or younger (OR, 1.26; 95% CI, 1.03 to 1.55). Conclusion ART recommendations for stage I seminoma are declining. Men in less educated regions and the youngest men were less likely to receive a recommendation for ART.
Posaconazole: An Oral Triazole with an Extended Spectrum of Activity
Authors: Rachwalski Erik J , Wieczorkiewicz Jeffrey T , Scheetz Marc H 
Published: August 2008

Objective: To summarize the published clinical data on posaconazole, critically review the New Drug Application data submitted to the Food and Drug Administration, and provide information critical for evaluation and formulary positioning. Data Sources: Reported investigations were identified from MEDLINE (1966-June 30, 2008), bibliographies of manuscripts, www.clinicaltrials.gov , and www.fda.gov . Study Selection and Data Extraction: English-language articles were selected. AN available in vitro, animal, clinical, and human studies describing the pharmacology, pharmacokinetics, pharmacodynamics, efficacy, safety, and adverse events of posaconazole were reviewed. Data Synthesis: Posaconazole is an oral broad-spectrum triazole with activity against many yeasts and molds. Resistance to posaconazole has been reported, but has been rare to date. Posaconazole, in doses of 200 mg 3 limes daily, reduced breakthrough invasive fungal infections (OR 0.30; 95% CI 0.12 to 0.71) and aspergillosis incidence (OR 0.31; 95% CI 0.13 to 0.75) in patients receiving hematopoietic stem-cell transplants compared with those receiving fluconazole. Similarly, the same regimen of posaconazole reduced invasive fungal infections (95% CI -9.7 to -2.5) and aspergillosis (CI not reported, p < 0.001) when compared with fluconazole and itraconazole in neutropenic patients. Posaconazole is non-inferior to fluconazole for treatment of oropharyngeal candidiasis (95% CI -6.6 to 5.0), but necessity for this indication remains unclear, as many other treatment options exist. Smaller investigations have analyzed use of posaconazole for patients requiring salvage or alternative treatment for zygomycosis, fusarbsis, cryptococcal meningitis, coccidioidomycosis, and histoplasmosis. Studies are needed to clarify efficacy for such expanded use, and therapeutic drug monitoring may improve outcomes. The most common adverse effects associated with the use of posaconazole include headache, fever, nausea, vomiting, and diarrhea. Conclusions: Posaconazole appears to be a valuable and promising addition to the antifungal armamentarium for prophylaxis and treatment of various fungal processes. At this time, posaconazole should probably be reserved for prophylaxis in patients at high risk for invasive fungal infection, as salvage therapy in refractory or resistant infections, or for patients with intolerance to other therapies.
1,3,2-Oxathiaphospholane approach to the synthesis of P-chiral stereodefined analogs of oligonucleotides and biologically relevant nucleoside polyphosphates
Authors: Nawrot Barbara , Rębowska Beata , Michalak Olga , Bulkowski Marek , Błaziak Damian , Guga Piotr , Stec Wojciech J. 
Published: August 2008

Abstract
Among the various classes of modified nucleotides and oligonucleotides, phosphorothioate analogs, in which the sugar-phosphate backbone is modified by the substitution of a sulfur atom for one of the nonbridging oxygen atoms, have been most extensively studied in both in vitro and in vivo experiments. However, this substitution induces P-chirality of the dinucleoside phosphorothioate moiety. Consequently, even short phosphorothioate oligonucleotides synthesized using standard chemical methods exist as mixtures of many diastereoisomers. In our laboratory, the oxathiaphospholane (OTP) method has been developed for a stereocontrolled synthesis of oligo(deoxyribonucleoside phosphorothioate)s. Recently, this approach has been extended to ribonucleoside derivatives, and stereodefined phosphorothioate diribonucleotides were incorporated into oligomers suitable for mechanistic studies on deoxyribozymes. Next, it was found that the OTP ring can be opened with nucleophiles as weak as the phosphate or pyrophosphate anion, giving rise to nucleoside α-thiopolyphosphates. Surprisingly, the reaction between nucleoside OTP and O,O-dialkyl H-phosphonate or O,O-dialkyl H-phosphonothioate led to nucleoside 5'-O-(α-thio-β-O,O-dialkyl-hypophosphate) or 5'-O-(α,β-dithio-β-O,O-dialkyl-hypophosphate), respectively, i.e., derivatives containing a direct P-P bond.
The exceptionally high life expectancy of Costa Rican nonagenarians
Authors: Rosero-Bixby Luis 
Published: August 2008

AbstractRobust data from a voter registry show that Costa Rican nonagenarians have an exceptionally high live expectancy. Mortality at age 90 in Costa Rica is at least 14% lower than an average of 13 high-income countries. This advantage increases with age by 1% per year. Males have an additional 12% advantage. Age-90 life expectancy for males is 4.4 years, one-half year more than any other country in the world. These estimates do not use problematic data on reported ages, but ages are computed from birth dates in the Costa Rican birth-registration ledgers. Census data con rm the exceptionally high survival of elderly Costa Ricans, especially males. Comparisons with the United States and Sweden show that the Costa Rican advantage comes mostly from reduced incidence of cardiovascular diseases, coupled with a low prevalence of obesity, as the only available explanatory risk factor. Costa Rican nonagenarians are survivors of cohorts that underwent extremely harsh health conditions when young, and their advantage might be just a heterogeneity in frailty effect that might disappear in more recent cohorts. The availability of reliable estimates for the oldest-old in low- income populations is extremely rare. These results may enlighten the debate over how harsh early-life health conditions affect older-age mortality.
Mate availability and unmarried parent relationships
Authors: Harknett Kristen 
Published: August 2008

Abstract
Theoretically, a shortage of males in a local marriage market may influence the formation, quality,and trajectory of unmarried parent relationships. To test these hypotheses, I combine city-level sex ratio data from the U.S. census with microdata on unmarried couples who recently had a child from the Fragile Families and Child Wellbeing study. A shortage of men in a marriage market is associated with lower relationship quality for unmarried parents. Male shortages are associated with lower rates of marriage following a nonmarital birth, in part because of the mediating influence of relationship quality. A shortage of men is not significantly related to the economic quality of male, nonmarital childbearing partners.
The changing relationship between family size and educational attainment over the course of socioeconomic development: Evidence from Indonesia
Authors: Maralani Vida 
Published: August 2008

AbstractMany studies from developed countries show a negative correlation between family size and children’s schooling, while results from developing countries show this association ranging from positive to neutral to negative, depending on the context. The body of evidence suggests that this relationship changes as a society develops, but this theory has been difficult to assess because the existing evidence requires comparisons across countries with different social structures and at different levels of development. The world’s fourth most populous nation in 2007, Indonesia has developed rapidly in recent decades. This context provides the opportunity to study these relationships within the same rapidly developing setting to see if and how these associations change. Results show that in urban areas, the association between family size and children’s schooling was positive for older cohorts but negative for more recent cohorts. Models using instrumental variables to address the potential endogeneity of fertility con rm these results. In contrast, rural areas show no significant association between family size and children’s schooling for any cohort. These findings show how the relationship between family size and children’s schooling can differ within the same country and change over time as contextual factors evolve with socioeconomic development.
Gay and lesbian partnership: Evidence from California
Authors: Carpenter Christopher , Gates Gary J. 
Published: August 2008

Abstract
Much recent research on sexual minorities has used couples-based samples, which&#x2014;by construction&#x2014;provide no information on nonpartnered individuals. We present the first systematic empirical analysis of partnership and cohabitation among self-identified gay men and lesbians using two independent, large, population-wwbased data sources from California. These data indicate that 37%–46% of gay men and 51%–62% of lesbians aged 18–59 are in cohabiting partnerships (compared with 62% of heterosexual individuals in coresidential unions at comparable ages). Unlike previous research, we find that white and highly educated gay men and lesbians are more likely to be partnered, and we confirm that same-sex cohabiting partners in our data have demographic characteristics that are similar to California same-sex couples from Census 2000. We also present the first detailed analysis of officially registered domestic partnerships in California. We find that almost half of partnered lesbians are officially registered with the local or state government, while less than a quarter of partnered gay men are officially registered. We conclude with implications of our findings for couples-based research on gay men and lesbians, as well as recommendations for survey data collection.
Have we put an end to social promotion? Changes in school progress among children aged 6 to 17 from 1972 to 2005
Authors: Frederick Carl B. , Hauser Robert M. 
Published: August 2008

Abstract
We examine trends over time in the proportion of children below the modal grade for their age (BMG), a proxy for grade retention, and in the effects of its demographic and socioeconomic correlates. We estimate a logistic regression model with partial constraints predicting BMG using the annual October school enrollment supplements of the Current Population Survey. This model identifies systematic variation in the effects of social background across age and time from 1972 to 2005. While the effects of socioeconomic background variables on progress through school have become increasingly powerful as children grow older, that typical pattern has been attenuated across the past three decades by a steady secular decline in the influence of those variables across all ages. A great deal of concern has been expressed about rising levels of economic and social inequality in the United States since the middle 1970s, and about the potential intergenerational effects of such inequality. However, there has been an opposite trend in the effects of social origins on being BMG. A trend is not a law, and there is reason to be concerned about the recent deceleration of the secular decline in effects of social background on being BMG.
Social capital and migration: How do similar resources lead to divergent outcomes?
Authors: Garip Filiz 
Published: August 2008

Abstract
This article investigates how migrant social capital differentially influences individuals’ migration and cumulatively generates divergent outcomes for communities. To combine the fragmented findings in the literature, the article proposes a framework that decomposes migrant social capital into resources (information about or assistance with migration), sources (prior migrants), and recipients (potential migrants). Analysis of multilevel and longitudinal data from 22 rural villages in Thailand shows that the probability of internal migration increases with the available resources, yet the magnitude of increase depends on recipients’ characteristics and the strength of their ties to sources. Specifically, individuals become more likely to migrate if migrant social capital resources are greater and more accessible. The diversity of resources by occupation increases the likelihood of migration, while diversity by destination inhibits it. Resources from weakly tied sources, such as village members, have a higher effect on migration than resources from strongly tied sources in the household. Finally, the importance of resources for migration declines with recipients’ own migration experience. These findings challenge the mainstream account of migrant social capital as a uniform resource that generates similar migration outcomes for different groups of individuals or in different settings. In Nang Rong villages, depending on the configuration of resources, sources, and recipients, migrant social capital leads to differential migration outcomes for individuals and divergent cumulative migration patterns in communities.
Technological innovation and inequality in health
Authors: Glied Sherry , Lleras-Muney Adriana 
Published: August 2008

Abstract
The effect of education on health has been increasing over the past several decades. We hypothesize that this increasing disparity is related to health-related technical progress: more-educated people are the first to take advantage of technological advances that improve health. We test this hypothesis using data on disease-specific mortality rates for 1980 and 1990, and cancer registry data for 1973–1993. We estimate education gradients in mortality using compulsory schooling as a measure of education. We then relate these gradients to two measures of health-related innovation: the number of active drug ingredients available to treat a disease, and the rate of change in mortality from that disease. We find that more-educated individuals have a greater survival advantage in those diseases for which there has been more health-related technological progress.
Does human capital raise earnings for immigrants in the low-skill labor market?
Authors: Hall Matthew , Farkas George 
Published: August 2008

AbstractWe use monthly Survey of Income and Program Participation data from 1996–1999 and 2001–2003 to estimate the determinants of differentiation in intercepts and slopes for age/earnings profiles of low-skill immigrant and native male workers. Our findings provide further depth of understanding to the“mixed” picture of earnings determination in the low-skill labor market that has been reported by others. On the positive side, many immigrants are employed in similar occupations and industries as natives. Both groups show substantial wage gains over time and generally receive similar returns to years of schooling completed. Immigrants also receive substantial returns to acculturation, measured as age at arrival and English language skill. These results cast doubt on the strong version of segmented labor market theory, in which low-skill immigrants are permanently consigned to dead-end jobs with no wage appreciation. On the negative side, immigrants earn approximately 24% less than natives and are less likely to occupy supervisory and managerial jobs. Latino immigrants receive lower returns to education than do white immigrants. Furthermore, age at arrival and language ability do not explain the lower returns to education experienced by Latino immigrants. These results suggest that Latino immigrants in particular may suffer from barriers to mobility and/or wage discrimination. Whether these negative labor market experiences occur primarily for illegal immigrants remains unknown.
The geographic scale of Metropolitan racial segregation
Authors: Reardon Sean F. , Matthews Stephen A. , O’Sullivan David , Lee Barrett A. , Firebaugh Glenn , Farrell Chad R. , Bischoff Kendra 
Published: August 2008

Abstract
This article addresses an aspect of racial residential segregation that has been largely ignored in prior work: the issue of geographic scale. In some metropolitan areas, racial groups are segregated over large regions, with predominately white regions, predominately black regions, and so on, whereas in other areas, the separation of racial groups occurs over much shorter distances. Here we develop an approach—featuring the segregation profile and the corresponding macro/micro segregation ratio—that offers a scale-sensitive alternative to standard methodological practice for describing segregation. Using this approach, we measure and describe the geographic scale of racial segregation in the 40 largest U.S. metropolitan areas in 2000. We find considerable heterogeneity in the geographic scale of segregation patterns across both metropolitan areas and racial groups, a heterogeneity that is not evident using conventional “aspatial” segregation measures. Moreover, because the geographic scale of segregation is only modestly correlated with the level of segregation in our sample, we argue that geographic scale represents a distinct dimension of residential segregation. We conclude with a brief discussion of the implications of our findings for investigating the patterns, causes, and consequences of residential segregation at different geographic scales.
Migration, fertility, and aging in stable populations
Authors: Alho Juha M. 
Published: August 2008

Abstract
Fertility is below replacement level in all European countries, and population growth is expected to decline in the coming decades. Increasing life expectancy will accentuate concomitant aging of the population. Migration has been seen as a possible means to decelerate aging. In this article, I introduce a stable, open-population model in which cohort net migration is proportional to births. In this case, the migration-fertility trade-off can be studied with particular ease. I show that although migration can increase the growth rate, which tends to make the age distribution younger, it also has an opposite effect because of its typical age pattern. I capture the effect of the age pattern of net migration in a migration-survivor function. The effect of net migration on growth is quantified with data from 17 European countries. I show that some countries already have a level of migration that will lead to stationarity. For other countries with asymptotically declining population, migration still provides opportunities for slowing down aging of the population as a whole.
Reexamining the moving to opportunity study and its contribution to changing the distribution of poverty and ethnic concentration
Authors: Clark William A. V. 
Published: August 2008

AbstractFor the past decade and a half, a concerted effort has been undertaken to determine whether policy interventions in residential location can solve the problems of inner-city poverty and racial concentration. Studies based on data from the Gautreaux litigation and the U.S. Department of Housing and Urban Development (HUD)—sponsored Moving to Opportunity (MTO) program have provided an overall optimistic interpretation of the possibilities of improving inner-city lives via mobility vouchers and counseling. A reanalysis of the data from the MTO program, focusing specifically on African American households, suggests greater caution in the interpretation of the findings from either Gautreaux or the MTO program. No statistically significant difference exists between the percentage of poor or the percentage of African Americans in the current neighborhoods between MTO and Section 8 experimental groups. In some cases, there is no statistically significant difference between those who move with a voucher and those who move without any assistance at all. Although there is some evidence that MTO programs have brought specific gains for individual families, claims for the MTO program as a whole need to be treated with a great deal more caution than they have been to date.