bluuebunny/crossref_metadata_2025_split huggingface dataset:
Low-Grade Systemic Inflammation Causes Endothelial Dysfunction in Patients with Hashimoto’s Thyroiditis
Authors: Taddei Stefano , Caraccio Nadia , Virdis Agostino , Dardano Angela , Versari Daniele , Ghiadoni Lorenzo , Ferrannini Ele , Salvetti Antonio , Monzani Fabio 
Published: September 2006

Abstract
Objective: The objective of this study was to assess whether low-grade systemic inflammation might contribute to the pathogenesis of endothelial dysfunction in patients with subclinical hypothyroidism (sHT) and autoimmune thyroiditis.
Background: sHT patients are characterized by peripheral endothelial dysfunction and low-grade inflammation.
Methods: In 53 sHT and 45 healthy subjects, we studied the forearm blood flow (strain-gauge plethysmography) response to intrabrachial acetylcholine (Ach) (0.15–15 μg/min·dl) with and without local vascular COX inhibition by intrabrachial indomethacin (50 μg/min·dl) or nitric oxide synthase blockade by N-mono methyl arginine (l-NMMA) (100 μg/min·dl) or the antioxidant vitamin C (8 mg/min·dl). The protocol was repeated 2 h after systemic nonselective COX inhibition (100 mg indomethacin) or selective COX-2 blockade (200 mg celecoxib) oral administrations.
Results: sHT patients showed higher C-reactive protein and IL-6 values. In controls, vasodilation to Ach was blunted by l-NMMA and unchanged by vitamin C. In contrast, in sHT, the response to Ach, reduced in comparison with controls, was resistant to l-NMMA and normalized by vitamin C. In these patients, systemic but not local indomethacin normalized vasodilation to Ach and the inhibition of l-NMMA on Ach. Similar results were obtained with celecoxib. When retested after indomethacin administration, vitamin C no longer succeeded in improving vasodilation to Ach in sHT patients. Response to sodium nitroprusside was unchanged by indomethacin or celecoxib.
Conclusions: In sHT patients, low-grade chronic inflammation causes endothelial dysfunction and impaired nitric oxide availability by a COX-2-dependent pathway leading to increased production of oxidative stress.
Assessment of Iodine Status Using Dried Blood Spot Thyroglobulin: Development of Reference Material and Establishment of an International Reference Range in Iodine-Sufficient Children
Authors: Zimmermann Michael B. , de Benoist Bruno , Corigliano Sandro , Jooste Pieter L. , Molinari Luciano , Moosa Khairya , Pretell Eduardo A. , Al-Dallal Zuhair Salman , Wei Yao , Zu-Pei Chen , Torresani Toni 
Published: September 2006

Abstract
Context: Thyroglobulin (Tg) may be a valuable indicator of improving thyroid function in children after salt iodization. A recently developed Tg assay for use on dried whole blood spots (DBS) makes sampling practical, even in remote areas.
Objective: The study aim was to develop a reference standard for DBS-Tg, establish an international reference range for DBS-Tg in iodine-sufficient children, and test the standardized DBS-Tg assay in an intervention trial.
Design, Participants, and Interventions: Serum Tg reference material of the European Community Bureau of Reference (CRM-457) was adapted for DBS and its stability tested over 1 yr. DBS-Tg was determined in an international sample of 5- to 14-yr-old children (n = 700) who were euthyroid, anti-Tg antibody negative, and residing in areas of long-term iodine sufficiency. In a 10-month trial in iodine-deficient children, DBS-Tg and other indicators of iodine status were measured before and after introduction of iodized salt.
Results: Stability of the CRM-457 Tg reference standard on DBS over 1 yr of storage at −20 and −50 C was acceptable. In the international sample of children, the third and 97th percentiles of DBS-Tg were 4 and 40 μg/liter, respectively. In the intervention, before introduction of iodized salt, median DBS-Tg was 49 μg/liter, and more than two thirds of children had DBS-Tg values greater than 40 μg/liter. After 5 and 10 months of iodized salt use, median DBS-Tg decreased to 13 and 8 μg/liter, respectively, and only 7 and 3% of children, respectively, had values greater than 40 μg/liter. DBS-Tg correlated well at baseline and 5 months with urinary iodine and thyroid volume.
Conclusions: The availability of reference material and an international reference range facilitates the use of DBS-Tg for monitoring of iodine nutrition in school-age children.
Bell's Palsy: A Review of Treatment Using Antiviral Agents
Authors: Alberton Dario L , Zed Peter J 
Published: September 2006

Objective: To review the evidence evaluating the efficacy and safety of antiviral agents to reduce morbidity associated with Bell's palsy. Data Sources: MEDLINE, EMBASE, and PubMed were searched (all up to April 2006) for English-language, prospective, randomized, controlled clinical trials that evaluated the use of antiviral agents in Bell's palsy. Search terms included Bell's palsy, acyclovir, valacyclovir, famciclovir, and randomized controlled trials. Study Selection and Data Extraction: Prospective, randomized, controlled trials that evaluated efficacy and safety endpoints of antiviral agents in the treatment of Bell's palsy were included. Primary efficacy outcomes included facial paralysis recovery profile, facial paralysis recovery index, and the House–Brackmann facial nerve grading scale. Safety outcomes were also identified by each trial. Data Synthesis: Two prospective, randomized clinical trials were included in this review, both involving the use of acyclovir for treatment of Bell's palsy. Acyclovir monotherapy was shown to be inferior to prednisone monotherapy; however, the combination of acyclovir and prednisone was found to be superior to prednisone alone. There are limited data describing the safety of acyclovir in Bell's palsy. Conclusions: The use of acyclovir in the treatment of Bell's palsy remains controversial. Additional, adequately powered, randomized, placebo-controlled trials are needed to definitively support its use. For the time being, the evidence reviewed in this article would favor the combination of acyclovir and prednisone if commenced within the first 72 hours of symptom onset.
Oxcarbazepine Use in Essential Tremor
Authors: Raj Vidya , Landess Jacqueline S , Martin Peter R 
Published: September 2006

Objective: To report the novel finding of a significant improvement in essential tremor symptoms with oxcarbazepine in a patient with a suboptimal response to propranolol. Case Summary: A 40-year-old woman with a history of substance abuse complicated by essential tremor and neuropathic pain was admitted to our addictions unit with altered mental state due to escalating use of alprazolam. Alprazolam had been prescribed several months prior to admission for treatment of anxiety. The doses had risen to 5–10 mg/day during that period. Apparently, her essential tremor had responded inadequately to propranolol, but had responded well to alprazolam. She was started on a sedative/hypnotic withdrawal protocol, but did not require treatment with phenobarbital. She subsequently rated her tremor as “moderately severe.” On discontinuation of the withdrawal protocol, oxcarbazepine 450 mg twice daily was initiated to treat her neuropathic pain, and the tremor improved, with a clinically significant reduction in tremor and a decreased pain score. Discussion: Essential tremor is a common neurologic disorder with uncertain pathophysiology. Practice guidelines advocate the use of propranolol or primidone as first-line agents to treat essential tremor. Unfortunately, primidone has abuse potential and propranolol has variable pharmacokinetics; these characteristics limit their effectiveness in treating tremor. Our patient experienced a significant and sustained improvement in her tremor following the initiation of oxcarbazepine. To our knowledge, as of September 2, 2006, this is the first report of the use of oxcarbazepine in essential tremor. While the exact therapeutic action remains unclear, oxcarbazepine offers significant advantages compared with current first-line agents, including its good tolerability profile, the extended half-life of its metabolite, and lack of abuse potential. Conclusions: We report a case of essential tremor responding to oxcarbazepine. This drug offers several potential advantages over current first-line agents. Further research is warranted to test the robustness of this preliminary finding.
A Comparative Study of Consumer Participation in Mental Health Pharmacy Education
Authors: Bell J Simon , Johns Rachelle , Rose Grenville , Chen Timothy F 
Published: September 2006

Background: People with mental illness have been recognized as key stakeholders in the development of mental health education. However, few studies have evaluated the impact of people with mental illness as participants in education programs for students studying to become health professionals. Objective: To assess the impact of education provided by mental health consumer–educators on the attitudes of pharmacy students toward people with mental illness. Methods: The study used a 2 group, nonrandomized, clustered, comparative design, with 4 tutorial classes allocated to receive standard pharmacist-led instruction (comparison group), and 5 tutorial classes to receive standard pharmacist-led instruction plus additional input from mental health consumer–educators (intervention group). All pharmacy students (N = 229) enrolled in the third year of a 4 year pharmacy degree program were invited to participate. Consumer–educators receiving ongoing treatment for illnesses including schizophrenia, bipolar disorder, and major depression participated in small-group work, case-study discussions, and role plays with pharmacy students in the intervention group. Pharmacy students' attitudes were assessed using a 39 item survey instrument derived from previously published instruments evaluating social distance, attribution, provision of pharmaceutical services, and stigmatization of people with schizophrenia and severe depression. Results: Paired baseline and follow-up responses were obtained from 117 students in the intervention group and 94 students in the comparison group. Students who received the consumer intervention had decreased social distance scores (F(1209) = 5.30; p = 0.02). Students in the intervention group more strongly disagreed with 26 of 27 nonsocial distance statements that demonstrated a negative attitude toward people with mental illness (F(1209) = 13.58; p < 0.001) and more strongly agreed with all 4 nonsocial distance statements that demonstrated a positive attitude (F(1209) = 7.56; p = 0.014). Conclusions: Consumer participation in mental health education for pharmacy students improves students' attitudes toward people with mental illness.
Clinical Outcomes Associated with Concomitant Use of Atazanavir and Proton Pump Inhibitors
Authors: Sahloff Eric G , Duggan Joan M 
Published: September 2006

Background: Pharmacokinetic studies have shown that the concomitant use of atazanavir and proton pump inhibitors (PPIs) decreases atazanavir plasma concentrations. Data describing clinical outcomes associated with this drug interaction are limited. Objective: To describe the clinical outcomes, in terms of viral load (VL) suppression, associated with the concurrent use of ritonavir-boosted or unboosted atazanavir and PPIs. Methods: A retrospective chart review of 301 HIV-positive adults attending an Ohio infectious diseases clinic was performed to identify patients prescribed atazanavir, with or without ritonavir, and a PPI. The primary outcome was achievement/maintenance of VL less than 400 copies/mL for 2 or more months during concomitant atazanavir and PPI therapies. Data collected included VL and CD4+ cell count at initiation of coadministered atazanavir and PPIs, genotype/phenotype, prior protease inhibitor experience, length of concurrent atazanavir/PPI therapy, and adherence. Results: Twelve patients met inclusion criteria. PPIs and dosing regimens varied among subjects. Five of the subjects had a VL less than 400 copies/mL at initiation of atazanavir, with or without ritonavir, which was maintained during concurrent atazanavir and PPI therapy. Four additional subjects initiated protease inhibitor treatment with a VL greater than 400 copies/mL and achieved an undetectable VL while on concurrent PPI therapy. Duration of concurrent therapy ranged from 4 to 23 months in these 9 subjects. Of the 3 patients not maintaining a VL less than 400 copies/mL, 1 achieved that level at 4 months, and all 3 of these subjects showed atazanavir susceptibility during therapy per genotype resistance testing. Subsequently, decreased atazanavir susceptibility was reported in 1 of the 3 patients after 18 months of therapy. Patients not achieving an undetectable VL had known adherence issues. Conclusions: In this case series, 9 of 12 subjects achieved successful virologic outcomes while receiving concurrent atazanavir and PPIs in a real-world environment. In our experience, the interaction between atazanavir and once-daily PPIs is not clinically significant for adherent patients. Concurrent use of these medications could be considered in patients with limited treatment options.
Supplementary Prescribing: Early Experiences of Pharmacists in Great Britain
Authors: George Johnson , McCaig Dorothy J , Bond Christine M , Cunningham IT Scott , Diack H Lesley , Watson Anne M , Stewart Derek C 
Published: September 2006

Background: Pharmacists in Great Britain can undertake supplementary prescribing (SP) after training at a higher education institution and completing a “period of learning in practice” in accordance with the Royal Pharmaceutical Society of Great Britain (RPSGB) curriculum. Objective: To explore SP pharmacists' early experiences of prescribing and their perceptions of the prescribing course. Methods: A questionnaire was mailed to all RPSGB prescribers (N = 518, on June 1, 2005; 30 used in pilot questionnaire). Predictors of pharmacists starting to practice SP were identified in univariate analysis, and significant variables were further tested in multivariate analysis. Results: The respondents (n = 401; 82.2%) were mainly female (270; 67.3%), had more than 20 years' experience as a pharmacist (123; 30.7%), worked in hospital settings (160; 39.9%), and focused on cardiovascular conditions (143; 35.7%) during their period of learning in practice. The median course satisfaction score, on a scale of 3 to 15 (lowest to highest), was 10. Practicing SP was self-reported by 195 (48.6%) respondents, 154 (79%) of whom had written a prescription. Ninety (58.4%) of the first prescriptions were written in primary care settings. Better patient management was regarded as the major benefit by 139 (71.3%) of those engaged in SP, while funding issues were identified by 71 (36.4%) as major barriers in implementing the practice. Lack of organizational recognition of SP was the main reason given (37; 18%) for those not commencing the practice. Independent predictors of those practicing SP included a longer time since registering as prescriber (p < 0.001); confidence of pharmacists in their prescribing abilities (p < 0.001); practicing in a setting other than community pharmacy (p = 0.001); and training in cardiovascular conditions or multiple conditions during the period of learning in practice (p = 0.005). Conclusions: Pharmacists have made progress in implementing SP, which is perceived by pharmacist prescribers as beneficial for both patients and themselves. Pharmacists need more support in terms of infrastructure and integration into the healthcare team to overcome some of the barriers to implementing SP.
Hydrothermal Reactivity of Saponite
Authors: Whitney Gene 
Published: September 2006

AbstractSaponite crystallizes from amorphous gel having an ideal saponite composition within 7 days at all experimental temperatures between 300° and 550°C at 1 kbar pressure. Reactions subsequent to this initial crystallization vary in type and degree, depending on the temperature of reaction and the type of interlayer cation. Above 450°C, the intitially crystallized K-saponite dissolves, and talc and phlogopite nucleate and grow as discrete phases. At 450°C the initial K-saponite reacts to form talc and phlogopite layers, but the reaction proceeds via intracrystalline layer transformations rather than via dissolution and precipitation, producing a mixture of fully ordered, interstratified talc/saponite and fully ordered saponite/phlogopite. The K-saponite shows subtle signs of reaction at 400°C after 200 days: this temperature is at least 150°C lower than experimental reaction temperatures previously reported for saponites. No reactions beyond the initial crystallization of saponite were observed below 400°C. K-saponite reacts more rapidly than either Na-saponite or Ca-saponite above 400°C, and the Na-saponite and Ca-saponite produce no mica layers during their transformation to mixed-layer clays. Interstratified talc/saponite formed in the Na-saponite system, and the Ca-saponite system produced both talc/saponite and chlorite/saponite.
Physicochemical Properties of Montmorillonite Interlayered with Cationic Oxyaluminum Pillars
Authors: Occelli M. L. , Tindwa R. M. 
Published: September 2006

AbstractBy ion exchanging expandable clay minerals with large, cationic oxyaluminum polymers, “pillars” were introduced that permanently prop open the clay layers. On the basis of thermal, infrared spectroscopic, adsorption, and X-ray powder diffraction (XRD) analysis, the interlayering of commercial sodium bentonite with aluminum chlorohydroxide, [Al13O4(OH)24(H2O)12]+7, polymers appears to have produced an expanded clay with a surface area of 200–300 m2/g. The pillared product contained both Brönsted and Lewis acid sites. XRD and differential scanning calorimetry measurements indicated that the micropore structure of this interlayered clay is stable to 540°C. Between 540° and 760°C, the pillared clay collapsed with a corresponding decrease in surface area (to 55 m2/g) and catalytic cracking activity for a Kuwait gas oil having a 260°-426°C boiling range.
Adsorption of Quinoline from Aqueous Solutions by Some Clays and Oxides
Authors: Helmy A. K. , De Bussetti S. G. , Ferreiro E. A. 
Published: September 2006

AbstractThe adsorption isotherms of quinoline from aqueous solutions by some clays and oxides varied from the S type for silica to a form somewhat similar to the Langmuir type for montmorillonite and silica-alumina. The adsorption reaction reached equilibrium in about 2 hr and was irreversible. X-ray powder diffraction studies showed that a single layer of molecules is adsorbed on montmorillonite and that the molecules lie either flat or in an upright position depending on surface coverage. The adsorption showed high sensitivity towards pH, attaining a maximum at pH 6. The decrease below pH 6 was due to competition with protons as well as to problems inherent in surface packing of positively charged quinoline molecules. The decrease above pH 6 is probably due to more exchangeable metallic cations on the surface leading to a favored sorption of water over organic molecules.
Mineralogical Transformations During Weathering of Lignite Overburden in East Texas
Authors: Senkayi A. L. , Dixon J. B. , Hossner L. R. , Viani B. E. 
Published: September 2006

AbstractMineralogical weathering sequences in sediments overlying lignite beds were investigated in a core (27 m deep) from Calvert, Robertson County, northeast Texas. Weathering trends were evaluated based on the properties and relative distributions of both the expandable and non-expandable minerals. The sulfide minerals in these sediments are the most susceptible to weathering and were only observed in the unaltered (reduced) zone below 7 m. Oxidation of the sulfides has resulted in the formation of jarosite and gypsum in the upper 7 m of the core (oxidized zone). The oxidized zone is further characterized by reddish brown colors (high chroma), a greater quantity of dithionite-extractable iron, and absence of chlorite. Although the major clay minerals in these sediments (smectite, kaolinite, mica) are largely detrital, weathering has resulted in an increase in the content of kaolinite and a decrease in the content of mica towards the surface. The mica appears to have altered to a high-charge smectite characterized by basal spacings of 32 Â after intercalation with octadecylammonium cations. The high-charge smectite is most abundant in the soil horizons at the top of the core and gradually decreases with depth. A low-charge smectite is the most abundant species in the un weathered parent sediments and increases with depth. Key Words—Lignite, Oxidation, Reclamation, Smectite, Soil, Weathering.
Infrared Studies of Ni-Bearing Clay Minerals of the Kerolite-Pimelite Series
Authors: Gerard P. , Herbillon A. J. 
Published: September 2006

AbstractTwo kerolite and one garnierite samples were subjected to progressive heat treatments prior to their examination by infrared spectroscopy (IR) in the 1200-600-cm−1 and 3800-3000-cm−1 regions. The heat treatment of the garnierite (a mixture of nepouite and pimelite) selectively dehydroxylated the nepouite thus allowing an examination to be made of the OH-vibration bands due to the pimelite. Both the relative intensities of the 710-670-cm−1 doublet and of the different OH-stretching bands indicated the Ni content of this pimelite to be about 70%. The heat treatments did not modify the 1200-600-cm−1 region of the spectra of kerolites but caused a noticeable sharpening in the OH-stretching region. The relative intensities of the structural OH-stretching bands of dehydrated kerolites showed that they differ from Ni-talcs of similar composition in the distribution of Ni and Mg in the octahedral sites. These cations are randomly distributed in Ni-talc but are mainly segregated into Mg and Ni domains in kerolite. Changes in sharpness, intensity, and position of the structural OH-stretching bands of the kerolites as temperature increases and dehydration progresses are similar to those undergone by Mg- or Li-saturated trioctahedral smectites. Also thermal analysis curves of these minerals show similarities with those of Mg- and Ni-saturated smectites, and suggest that in kerolites too, the hydration water is associated with interlayer (though non-exchangeable) Ni and/or Mg cations.
Clay Minerals of Lake Abert, an Alkaline, Saline Lake
Authors: Jones Blair F. , Weir Alan H. 
Published: September 2006

AbstractMineralogical and chemical analyses of fine clay fractions from in and around Lake Abert, Lake County, Oregon, show that the pyroclastic rocks supplying detritus to the lake weather to a suite of layer silicate clay minerals varying from high-charge dioctahedral montmorillonite to montmorillonite/intergrade smectite-chlorite interstratifications. In the lake these clays extract K, Mg, and Si to form authigenic interstratified illite and a trioctahedral, Mg-rich mineral resembling stevensite in composition. Both the neoformed interstratifications contribute little unambiguously to X-ray powder diffraction patterns, which are dominated by the reflections of detrital clays. From limited data it appears that the illite occurs below 0.8 m depth in sediments of a possibly somewhat fresher (brackish) lake and the trioctahedral interstratification between 0.4 and 0.2 m depth in sediments of a lake of about the same size and salinity (about 30–90 g/kg) as that of the present lake.