bluuebunny/crossref_metadata_2025_split huggingface dataset:
Localized Attachment Loss in Pendred Syndrome: Incidental?
Authors: Sharma C.G. Dileep , Pradeep A.R. 
Published: April 2007

Background: Pendred syndrome is a rare, inherited, autosomal recessive disorder with an iodine organification defect of thyroxin produced by the thyroid gland. Its clinical features include sensorineural hearing loss, classically congenital and prelingual, and goiter.Methods: This is the first case report of Pendred syndrome in the dental literature with oral findings that include localized extensive attachment loss involving mandibular incisor teeth and idiopathic hypercementosis involving multiple teeth in addition to other oral manifestations, suggesting hypothyroidism‐like macroglossia and macrocheilia. Furthermore, serum alkaline phosphatase along with inorganic calcium and phosphate levels were also elevated. Peripheral neutrophil function test suggested a defective function of neutrophils.Results: Management of the case included augmenting thyroxin supplementation, in consultation with an endocrinologist, and extraction of hopeless mandibular central incisors followed by placement of immediate transitional dentures.Conclusion: A comprehensive medical history and systemic and laboratory evaluations should be considered a prerequisite to identify, manage, and report such rare conditions in routine clinical practice.
Two Human Hydroxyapatite‐Coated Dental Implants Retrieved After a 14‐Year Loading Period: A Histologic and Histomorphometric Case Report
Authors: Iezzi Giovanna , Scarano Antonio , Petrone Giovanna , Piattelli Adriano 
Published: April 2007

Background: Controversy over the long‐term clinical effectiveness of hydroxyapatite (HA)‐coated dental implants still persists, despite numerous clinical studies documenting high survival rates. Concerns about the degradation of the coating over the years have been raised; it has been speculated that resorption of the HA could produce a space between the implant and the bone with a resultant mechanical instability.Methods: Two HA‐coated implants were retrieved due to a fracture of the abutment screws after a loading period of 14 years and were treated to obtain thin ground sections for histologic evaluation.Results: At low‐power magnification, it was possible to observe that the HA coating was in contact with mature bone. No gaps or connective fibrous tissue was found at the implant–bone interface. No epithelial downgrowth was present. No acute or chronic inflammatory cell infiltrate was present at the implant–bone interface. No foreign body reaction was present in the peri‐implant tissues. Some osteocytes were in direct contact with the coating. For implant 1, the percentage of bone–titanium contact was 25% ± 2.1%, and the percentage of bone–HA contact was 35% ± 1.4%. The total bone–implant contact was ∼60%. The HA coating appeared to be resorbed in 46% ± 3.2% of the implant perimeter, especially in the coronal portions of the implant. For implant 2, the mean percentage of bone–HA contact was 13% ± 1.8%, and the mean percentage of bone–titanium contact was 15% ± 2.3%. The total bone–implant contact was ∼28%. The HA coating appeared to be resorbed for a mean of 68% ± 4.1% of the implant perimeter, especially in the coronal portion of the implant.Conclusions: No acute or chronic inflammatory cell infiltrate was present in the peri‐implant tissues. No signs of coating infection, fatigue, or failure were observed in two specimens. The HA coating may not be susceptible to degradation or dissolution under long‐term function.
Favorable Periodontal Healing of 1‐Wall Infrabony Defects After Application of Calcium Phosphate Cement Wall Alone or in Combination With Enamel Matrix Derivative: A Pilot Study With Canine Mandibles
Authors: Shirakata Yoshinori , Yoshimoto Takehiko , Goto Hisanori , Yonamine Yutaka , Kadomatsu Hideshi , Miyamoto Motoharu , Nakamura Toshiaki , Hayashi Chie , Izumi Yuichi 
Published: April 2007

Background: Although various periodontal regenerative therapies are used, their effects on non‐contained infrabony defects are unpredictable. Our previous studies showed that injectable, moldable, fast‐setting calcium phosphate cement (CPC) promoted histocompatible periodontal healing in 3‐wall intrabony defects. The present study evaluated healing patterns after surgical application of CPC walls with and without an enamel matrix derivative (EMD) in 1‐wall infrabony defects in dogs.Methods: One‐wall infrabony defects (5 × 5 × 4 mm) were created surgically on the mesial and distal sides of bilateral mandibular fourth premolars in four beagle dogs. After elevating a full‐thickness flap, exposed root surfaces were planed thoroughly. The 16 defects were assigned randomly to one of the following experimental conditions: CPC, CPC+EMD, EMD, and open flap debridement (OFD). Ten weeks post‐surgery, the animals were sacrificed, and histologic specimens were prepared for histomorphometric evaluation.Results: Defect sites treated with EMD only exhibited varying degrees of new cementum and new bone formation, whereas the OFD group presented only limited new cementum and bone formation. Defect sites where a CPC wall was implanted (CPC and CPC+EMD groups) revealed significantly greater regeneration of new bone and new cementum than in the EMD and OFD groups. No significant differences were observed between the CPC and CPC+EMD groups.Conclusions: CPC walls with and without EMD promoted regeneration of alveolar bone and cementum in 1‐wall infrabony defects. Space and stable wound healing are believed to be crucial for periodontal regeneration in non‐contained infrabony defects.
Transcription Factor 7-Like 2 (TCF7L2) Is Associated With Gestational Diabetes Mellitus and Interacts With Adiposity to Alter Insulin Secretion in Mexican Americans
Authors: Watanabe Richard M. , Allayee Hooman , Xiang Anny H. , Trigo Enrique , Hartiala Jaana , Lawrence Jean M. , Buchanan Thomas A. 
Published: April 2007

OBJECTIVE— Variation in transcription factor 7-like 2 (TCF7L2) gene has been shown to be associated with type 2 diabetes and diabetes-related quantitative traits. We examined variation in a 0.1-Mb region surrounding marker DG10S478 for association with diabetes-related quantitative traits in 132 Mexican-American families of a proband with previous gestational diabetes mellitus (GDM).
RESEARCH DESIGN AND METHODS— Study participants were phenotyped by an oral glucose tolerance test (OGTT) and an intravenous glucose tolerance test and by a dual-energy X-ray absorptiometry scan for percentage of body fat. Of the 42 tag single nucleotide polymorphisms (SNPs) genotyped, 15 were identified.
RESULTS— On univariate analysis, none of the SNPs showed association with diabetes-related quantitative traits. However, rs12255372 showed association with 30′ Δinsulin (OGTT 30′ min fasting insulin) in an interaction with percentage of body fat (Bonferroni-corrected P = 0.027). The effect of adiposity to increase 30′ Δinsulin was greater in subjects with the T allele. This interaction was not associated with acute insulin response to intravenous glucose. rs12255372 also showed an association with β-cell compensation for insulin resistance based on 30′ Δinsulin in an interaction with percentage of body fat (Bonferroni-corrected P = 0.014). rs12255372 was also associated with GDM (odds ratio [OR] 2.49 [95% CI 1.17–5.31]; P = 0.018) in our case-control sample.
CONCLUSIONS— We conclude that variation in TCF7L2 is associated with GDM and interacts with adiposity to alter insulin secretion in Mexican Americans. Our observations partly explain the increased ORs observed in previous associated studies when analyses were restricted to lean subjects and the variability in quantitative trait association results.
A Mutation in the TMD0-L0 Region of Sulfonylurea Receptor-1 (L225P) Causes Permanent Neonatal Diabetes Mellitus (PNDM)
Authors: Masia Ricard , De Leon Diva D. , MacMullen Courtney , McKnight Heather , Stanley Charles A. , Nichols Colin G. 
Published: April 2007

OBJECTIVE—We sought to examine the molecular mechanisms underlying permanenent neonatal diabetes mellitus (PNDM) in a patient with a heterozygous de novo L225P mutation in the L0 region of the sulfonylurea receptor (SUR)1, the regulatory subunit of the pancreatic ATP-sensitive K+ channel (KATP channel).
RESEARCH DESIGN AND METHODS—The effects of L225P on the properties of recombinant KATP channels in transfected COS cells were assessed by patch-clamp experiments on excised membrane patches and by macroscopic Rb-flux experiments in intact cells.
RESULTS—L225P-containing KATP channels were significantly more active in the intact cell than in wild-type channels. In excised membrane patches, L225P increased channel sensitivity to stimulatory Mg nucleotides without altering intrinsic gating or channel inhibition by ATP in the absence of Mg2+. The effects of L225P were abolished by SUR1 mutations that prevent nucleotide hydrolysis at the nucleotide binding folds. L225P did not alter channel inhibition by sulfonylurea drugs, and, consistent with this, the patient responded to treatment with oral sulfonylureas.
CONCLUSIONS—L225P underlies KATP channel overactivity and PNDM by specifically increasing Mg-nucleotide stimulation of the channel, consistent with recent reports of mechanistically similar PNDM-causing mutations in SUR1. The mutation does not affect sulfonylurea sensitivity, and the patient is successfully treated with sulfonylureas.
Diphenylamine‐Substituted Cruciform Oligo(phenylene vinylene): Enhanced One‐ and Two‐Photon Excited Fluorescence in the Solid State
Authors: He F. , Tian L. L. , Tian X. Y. , Xu H. , Wang Y. H. , Xie W. J. , Hanif M. , Xia J. L. , Shen F. Z. , Yang B. , Li F. , Ma Y. G. , Yang Y. Q. , Shen J. C. 
Published: April 2007

Abstract1,4‐di(4′‐N,N‐diphenylaminostyryl)benzene (DPA‐DSB) is a well known compound with a large two‐photon absorption (TPA) section and strong fluorescence in solution. However, the ease with which it crystallizes results in the formation of discontinuous crystalline phases during vacuum deposition processes, thereby greatly limiting its applicability in solid‐state devices. A cruciform dimer of DPA‐DSB, 2,5,2′,5′‐tetra(4′‐N,N‐diphenylaminostyryl)biphenyl (DPA‐TSB) is reported, wherein two DPA‐DSB molecules are linked through a central biphenyl bond. The DPA‐TSB molecules take on a cruciform configuration because of the steric crowding around the central biphenyl core, which has the effect of efficiently suppressing crystalline and intermolecular interactions. The neat DPA‐TSB solid shows strong green–blue fluorescence because of both steady‐state absorption as well as TPA. The DPA‐TSB solid exhibits a photoluminescence (PL) efficiency (ηsolid) of 29 % and a solid‐state two‐photon action cross section (δηsolid) of 954 GM (1 GM = 1 × 10–50 cm4 s photon–1 molecule–1), which is much greater than for the model compound DPA‐DSB (ηsolid = 16 % and δηsolid = 150 GM, where δ is the TPA cross section and η is the fluorescence quantum yield). Based on its high PL efficiency, good film‐forming ability, and strong TPA, DPA‐TSB seems to be a good candidate for applications in solid‐state optical devices.
UV‐vis‐Induced Vitrification of a Molecular Crystal
Authors: Naito T. , Sugawara H. , Inabe T. , Kitajima Y. , Miyamoto T. , Niimi H. , Asakura K. 
Published: April 2007

AbstractA charge‐transfer complex of 2,5‐dimethyl‐N,N′‐dicyanoquinonediimine (DM) with silver (crystalline Ag(DM)2, defined as α) is irreversibly transformed by UV‐vis illumination. Depending on the illumination conditions, three new types of solids (defined as γ, δ, and ϵ) with different structural and physical properties are obtained and examined by a variety of analytical techniques, including solid‐state, high‐resolution, cross‐polarization magic angle spinning (CP‐MAS)13C NMR, elemental analysis (EA), mass spectrometry (MS), X‐ray absorption fine structure (XAFS), and powder X‐ray diffraction (XRD). The CP‐MAS, EA, MS, and XAFS results indicate that compound γ is a glass state of Ag(DM)2. The transformation from crystalline (α) to amorphous (γ) solid Ag(DM)2is an irreversible exothermic glass transition (glass‐transition temperature 155.2 °C; ΔH = –126.8 kJ mol–1), which implies that the glass form is thermodynamically more stable than the crystalline form. Compound δ (Ag(DM)1.5) consists of silver nanoparticles (diameter (7 ± 2) nm ) dispersed in a glassy matrix of neutral DM molecules. The N–CN–Ag coordination bonds of the α form are not maintained in the δ form. Decomposition of α by intense illumination results in a white solid (ϵ), identified as being composed of silver nanoparticles (diameter (60 ± 10) nm). Physical and spectroscopic (XAFS) measurements, together with XRD analysis, indicate that the silver nanoparticles in both δ and ϵ are crystalline with lattice parameters similar to bulk silver; however, the magnetic susceptibilities differ from bulk silver.
Inside Front Cover: Anti‐Lotus Effect for Nanostructuring at the Leidenfrost Temperature (Adv. Mater. 9/2007)
Authors: Elbahri M. , Paretkar D. , Hirmas K. , Jebril S. , Adelung R. 
Published: April 2007

AbstractThe scanning electron microscopy image (tilted, colored) shown on the inside cover depicts a ring of zinc oxide particles. This ring was obtained from a droplet of a highly diluted solution of zinc acetate by overheating on a 250°C hot silicon substrate, a method reported by Rainer Adelung and co‐workers on p. 1262. The overheating creates an explosion, which results in a spray of microscale droplets that form many rings similar to the one shown over a macroscopic substrate surface.
β‐Amyloid is a substrate of autophagy in sporadic inclusion body myositis
Authors: Lünemann Jan D. , Schmidt Jens , Schmid Dorothee , Barthel Konstanze , Wrede Arne , Dalakas Marinos C. , Münz Christian 
Published: April 2007

AbstractObjectiveSporadic Inclusion Body Myositis (sIBM) is the most common acquired muscle disease in patients above 50 years of age. Apart from inflammation in the skeletal muscle, overexpression of amyloid precursor protein (APP) and intracellular accumulation of its proteolytic fragment β‐amyloid play a central role in the pathogenesis of sIBM. In neurodegenerative disorders, similar aggregations of aberrant proteins have recently been shown to be susceptible to autophagic degradation. Therefore, we analyzed macroautophagy of APP in human muscle cell lines and sIBM muscle biopsies.MethodsColocalization of APP with the essential autophagy protein Atg8/LC3, which associates with preautophagosomal and autophagosomal membranes via lipidation, was analyzed in the CCL‐136 muscle cell line and muscle biopsies by immunofluorescence. While APP was visualized with specific antibodies in the muscle cell line and in tissue sections. Atg8/LC3 localization was analyzed after GFP‐Atg8/LC3 transfection or with an Atg8/LC3 specific antiserum, respectively.ResultsWe demonstrate here that Atg8/LC3 colocalizes with APP in cultured human muscle cells. In addition, APP/β‐amyloid‐containing autophagosomes can be observed at increased frequency in muscle fibers of sIBM muscle biopsies, but not in non‐myopathic muscle or non‐vacuolated myopathic controls. APP/β‐amyloid and Atg8/LC3 double‐positive compartments were almost exclusively observed in degenerating muscle fibers of the type II (fast‐twitching) and were in part associated with overexpression of major histocompatibility complex (MHC) class I and II on myofibers and invasion by CD4+ and CD8+ cells.InterpretationThese findings indicate that APP/β‐amyloid is targeted for lysosomal degradation via macroautophagy and suggest that the autophagy pathway should be explored for its potential therapeutic merit in sIBM. Ann Neurol 2007;61:476–483
The complex relation between genotype and phenotype in motor neuron disease
Authors: Cañete‐Soler Rafaela , Schlaepfer William W. 
Published: April 2007

AbstractThe success in mapping genetic loci and identifying mutant genes in familial neurodegenerative disease has outpaced our ability to understand the linkage between genotype and phenotype of disease. The results have led to a backlog of genetic information with limited clarification of underlying disease mechanisms. A major dilemma is how mutations in widely expressed proteins lead to degeneration or dysfunction of small subsets of neurons. The problem raises fundamental questions as to the nature and interrelation of pathways that maintain the homeostasis of differentiated neurons. The issue also bears on the pathogenesis of sporadic forms of disease and prospective efficacy of therapeutic applications. This review examines the problem as it relates to motor neuron disease. Ann Neurol 2007
Pathological TDP‐43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations
Authors: Mackenzie Ian R. A. , Bigio Eileen H. , Ince Paul G. , Geser Felix , Neumann Manuela , Cairns Nigel J. , Kwong Linda K. , Forman Mark S. , Ravits John , Stewart Heather , Eisen Andrew , McClusky Leo , Kretzschmar Hans A. , Monoranu Camelia M. , Highley J. Robin , Kirby Janine , Siddique Teepu , Shaw Pamela J. , Lee Virginia M‐Y. , Trojanowski John Q. 
Published: April 2007

AbstractObjectiveAmyotrophic lateral sclerosis (ALS) is a common, fatal motor neuron disorder with no effective treatment. Approximately 10% of cases are familial ALS (FALS), and the most common genetic abnormality is superoxide dismutase‐1 (SOD1) mutations. Most ALS research in the past decade has focused on the neurotoxicity of mutant SOD1, and this knowledge has directed therapeutic strategies. We recently identified TDP‐43 as the major pathological protein in sporadic ALS. In this study, we investigated TDP‐43 in a larger series of ALS cases (n = 111), including familial cases with and without SOD1 mutations.MethodsUbiquitin and TDP‐43 immunohistochemistry was performed on postmortem tissue from sporadic ALS (n = 59), ALS with SOD1 mutations (n = 15), SOD‐1–negative FALS (n = 11), and ALS with dementia (n = 26). Biochemical analysis was performed on representative cases from each group.ResultsAll cases of sporadic ALS, ALS with dementia, and SOD1‐negative FALS had neuronal and glial inclusions that were immunoreactive for both ubiquitin and TDP‐43. Cases with SOD1 mutations had ubiquitin‐positive neuronal inclusions; however, no cases were immunoreactive for TDP‐43. Biochemical analysis of postmortem tissue from sporadic ALS and SOD1‐negative FALS demonstrated pathological forms of TDP‐43 that were absent in cases with SOD1 mutations.InterpretationThese findings implicate pathological TDP‐43 in the pathogenesis of sporadic ALS. In contrast, the absence of pathological TDP‐43 in cases with SOD1 mutations implies that motor neuron degeneration in these cases may result from a different mechanism, and that cases with SOD1 mutations may not be the familial counterpart of sporadic ALS. Ann Neurol 2007;61:427–434
Aluminum(III) complexes containing O,O chelating ligand
Authors: Dostál Libor , Jambor Roman , Císařová Ivana , Merna Jan , Holeček Jaroslav 
Published: April 2007

AbstractThe stoichiometric reactions of trimethylaluminum with 2,6‐(MeOCH2)2C6H3OH (LH) revealed compounds L3Al (1) and L2AlMe (2). On the other hand reaction of 1 equiv. of LH with trimethylaluminum did not lead to the formation of complex LAlMe2 (3), rather 2 together with Me3Al were observed as a result of a disproportionation of 3. Compounds 1 and 2 were characterized by elemental analysis, 1H and 13C NMR spectroscopy and in the case of 1 by X‐ray diffraction. Derivative 2 underwent transmetalation with Ph3SnOH, giving LSnPh3 (4) as the result of a migration of ligand L from the aluminum to the tin atom. The identity of 4 was established by elemental analysis, 1H, 13C and 119Sn NMR spectroscopy and 1H, 119Sn HMBC experiments. The system 2 and B(C6F5)3 in a 1:1 molar ratio was shown to be active in the polymerization of propylene oxide and ε‐caprolactone. Copyright © 2007 John Wiley & Sons, Ltd.
Application of FTIR spectroscopy for structural characterization of ternary poly(acrylic acid)–metal–poly(vinyl pyrrolidone) complexes
Authors: Moharram M. A. , Khafagi M. G. 
Published: April 2007

AbstractThe FTIR spectroscopic technique was used in the study of ternary polymer–metal complexes containing two polyelectrolytes of opposite charge and metal ions. The structure of the ternary (PAA‐Fe3+‐PVP) complexes was examined by following the changes in their infrared spectra. It was found that the shapes of the absorption bands of the resultant compounds are influenced by the presence of Fe3+. According to this result it was suggested that two types of structure which differ in the composition are formed, one of which results from the coordination of Fe3+ with PAA‐PVP complex and the other is due to the formation of Fe3+ polycarboxylate. Comparison between the spectrum of PAA‐PVP complex and those of the compounds resulted from the reaction between the two opposite charged electrolytes, PAA and PVP and each of the divalent metal chlorides NiCl2, CoCl2, CuCl2, and ZnCl2) led to the conclusion that a reaction took place between the divalent transition metal chlorides and the extent of reaction depends on the nature of metal ions and PAA‐PVP complex. The FTIR spectra of the precipitate resulted from the mixtures of PAA‐PVP and Ni(NO3)2 or Sr(NO3)2 were investigated. It was noted that the addition of Ni(NO3)2 or Sr(NO3)2 to the mixture of the electrolytes of PAA and PVP provoked appreciable changes in the characteristic spectral features of the complex resulting from the interaction of the metal ions with the polymer–polymer complex. The FTIR spectra of the precipitate resulted from the reaction between CeCl3, ErCl3, and LaCl3 were also investigated. It was concluded that a reaction took place between the rare earth metals and the PPC. This means that ternary polymer–metal–polymer complexes were formed. The extent of changes in the spectral features differs from metal to metal according to the nature of metal ions. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci, 2007
DSC study on the effect of cure reagents on the lignin base epoxy cure reaction
Authors: Sun Hongguang , Sun Gang , Lv Hong , Liu Yu , Zhao Binyuan , Zhu Na , Hu Keao 
Published: April 2007

AbstractThe cure reactions of liquid lignin base epoxy resin (LEPL) with three different curing agents, viz., methylhexahydrophthalic anhydride, maleic anhydride, and 2‐methyl‐4‐methylimidazole (EMI‐2,4), were investigated by Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry. Cure kinetics was evaluated using the multiple heating rate Kissinger method. The reactivities of the three curing agents were compared based on kinetics results obtained by DSC. FTIR spectra of these curing systems were also studied. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci 2007
Dyeing of polylactide fibers in supercritical carbon dioxide
Authors: Wen Huibing , Dai Jin Jin 
Published: April 2007

AbstractPolylactide (PLA) fibers were dyed with Disperse Blue 79 in supercritical carbon dioxide (SC‐CO2). The effects of dyeing conditions such as the temperature, pressure, and time on the dyeing and mechanical properties were discussed in comparison with those in water. A major advantage of dyeing PLA in SC‐CO2 over dyeing PLA in an aqueous medium was its much better retention of the fiber strength. The loss of the breaking strength of PLA dyed in SC‐CO2 at 120°C for 60 min was 9.22% versus a 44.66% loss in aqueous dyeing at the same temperature. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci, 2007