bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experimental study on the deterioration law of saturated and dry porous rocks
Authors: Zheng Zheng Qiushuang , Pang Lifu , Liu Weitao 
Published: March 2024

Abstract
The coal seam floor is highly susceptible to the formation of hole defects after mining disturbance. And the destabilization of rocks containing hole defects and water saturation can affect the risk of burst water in the floor. Based on this, experimental studies were carried out on saturated and dry three-hole sandstone specimens using conventional triaxial compression experiments. The results show that after saturation with water, the compressive strength of the saturated specimens decreases with the increase of the surrounding pressure compared with the dry specimens. The weakening effect of water on the strength of the porous rock was 20.19% on average. The maximum degradation of compressive strength of saturated specimens is 61.31% greater than that of dry specimens by 50.15%. The weakening effect of water on the three-hole specimens is greater. The fracture damage form formed on the specimen surface under low perimeter pressure (2 ~ 10MPa) is dominated by inclined shear fracture and splitting fracture, which is mainly subjected to compression shear. The saturated and dry three-hole specimens under medium-perimeter pressure (18 ~ 26MPa) indicate that the number of fractures formed is low. The saturated and dry specimens indicate the formation of parallel or coplanar fracture system. The specimens indicate the formation of fractures subject to shear, tension and shear expansion damage. The saturated and dry three-hole specimens under high perimeter pressure (34–42 MPa) form damage damage zones around the holes, which are significantly damaged by tension and expansion. The damage form of the specimen is mainly shear expansion and tension damage.
Addressing differences in cancer: a framework for synergistic programming in cancer prevention and control
Authors: Fairman Ciaran M. , Kava Christine M. , Beima-Sofie K. , Sakhuja M. , Masud M. , Dias E. , Sheng J. , Gorzelitz J. , Morshed A. , Green B. B. , Skiba M. B. , Madhivanan P. , Parthasarathy N. , Hirschey R. , Weg M.W. Vander , Hebert J 
Published: March 2024

Abstract
Background: Cancer remains a leading cause of death worldwide and continues to disproportionately impact certain populations. Several frameworks have been developed that illustrate the multiple determinants of cancer. Expanding upon the work of others, we present an applied framework for cancer prevention and control designed to help clinicians, as well as public health practitioners and researchers, better address differences in cancer outcomes.
Methods: The framework was developed by the Cancer Prevention and Control Research Network’s Health Behaviors Workgroup. An initial framework draft was developed based on workgroup discussion, public health theory, and rapid literature review on the determinants of cancer. The framework was refined through interviews and focus groups with Federally Qualified Health Center providers (n=2) and cancer patients (n=2); participants were asked to provide feedback on the framework’s causal pathways, completeness, and applicability to their work and personal life.
Results: The framework provides an overview of the relationships between sociodemographic inequalities, social and structural determinants, and key risk factors associated with cancer diagnosis, survivorship, and cancer morbidity and mortality across the lifespan. The framework emphasizes how health-risk behaviors like cigarette smoking interact with psychological, psychosocial, biological, and psychosocial risk factors, as well as healthcare-related behavior and other chronic diseases. Importantly, the framework emphasizes addressing social and structural determinants that influence health behaviors to reduce the burden of cancer and improve health equity. Aligned with previous theory, our framework underscores the importance of addressing co-occurring risk factors and disease states, understanding the complex relationships between factors that influence cancer, and assessing how multiple forms of inequality or disadvantage intersect to increase cancer risk across the lifespan.
Conclusions: This paper presents an applied framework for cancer prevention and control to address cancer differences. Because the framework highlights determinants and factors that influence cancer risk at multiple levels, it can be used to inform the development, implementation, and evaluation of interventions to address cancer morbidity and mortality.
A Study of Risk Factors Associated with Clinical Outcomes Following Surgery for Degenerative Lumbar Scoliosis
Authors: Zheng Xiao , Wang Yunsheng , Wang Ruiling , Miao Dechao , Wang Feng , Tong Tong 
Published: March 2024

Abstract
Objective: To investigate the risk factors for the prognosis of degenerative lumbar scoliosis after surgery.
Methods: A retrospective analysis was performed to compare the preoperative and postoperative clinical data to assess the prognosis, and to evaluate the patients after surgery by combining the Oswestry Disability Index (ODI) Quality of life. Based on different surgical outcomes, we divide patients into a better prognosis group and a poor prognosis group. Comprehensive risk factors were collected which may related to clinical outcomes included three aspects: patient general status, surgery-related data and imaging parameters. All risk factors were first analyzed through single risk factor analysis, and then multiple logistic regression analysis and Receiver Operating Characteristic (ROC) curves were used to analyze factors related to prognosis after orthopedic surgery.
Results: One hundred and thirty-four patients with degenerative lumbar scoliosis who undergone posterior surgery were included in this study. There were 36 men and 98 women with a mean age of 59.4±7.8 years. After identifying potential risk factors that may affect postoperative efficacy through univariate logistic regression, multivariate logistic regression analysis showed that the subcutaneous fat tissue thickness (SFTT) (OR=0.410, P=0.043) , MRI-based vertebral bone quality (VBQ) (OR=0.076, P=0.037), Quantitative Computed Tomography (QCT) (OR=1.401, P=0.008) , degree of kyphosis correction (OR=1.399, P=0.021), sagittal balance correction distance (OR=2.634, P=0.011) were independent predictors of poor prognosis. ROC curve analysis showed that correction degree of kyphosis >20.23°(AUC=0.881, P=0.001), sagittal balance correction distance >2.92CM (AUC=0.834, P=0.001) , QCT >104.6mg/cm3(AUC=0.958, P=0.001)，VBQ <2.88(AUC=0.669, P=0.001)，SFTT <13.5 mm (AUC=0.740, P=0.001) were indicating good clinical efficacy.
Conclusions: In patients with degenerative lumbar scoliosis, posterior decompression and fixed fusion surgery can significantly relieve pain and improve quality of life. Among the many factors that may affect prognosis, the correction of kyphosis and sagittal balance is particularly crucial for the postoperative quality of life. Due to the impact of SFTT, VBQ, and QCT on clinical prognosis, patients are encouraged to undergo anti-osteoporosis treatment and early lumbar and dorsal muscle exercise.
Effect of Steel Fibers on the Interfacial Shear Strength of Flyash and GGBS based Geopolymer concrete activated with water glass
Authors: Sangi Rajashekar , Bollaprag Sesha Sreenivas 
Published: March 2024

Abstract
Concrete, a fundamental construction material, heavily relies on cement, manufacturing process of cement results in significant CO2 emissions, posing environmental concerns. Hence, exploring substitutes for cement becomes imperative to mitigate CO2 emissions. Geopolymer materials emerge as promising alternatives capable of entirely replacing Ordinary Portland Cement (OPC). However, these materials necessitate activators to initiate the polymerization reaction. While Na2SiO3 and NaOH are commonly utilized as activators, their cost-effectiveness is questionable. Moreover, when Ground Granulated Blast Furnace Slag (GGBS) reacts rapidly with these activators. To address these issues and streamline concrete production, "water glass" is employed as an activator, offering a solution to avoid rapid setting and economize the production process. In other hand the production of mass concrete structures, interfaces and joints critical points where cracks may develop. To ensure monolithic behavior, shear ties were advised at the interface in order to establish strong bond strength. However, the efficiency of construction could be decreased by adding more shear ties. The purpose of this study is to evaluate the interfacial shear strength of Geopolymer concrete(GPC), With the addition of different percentages (0.5,1%, 1.5%, and 2%), and 30mm length of crimpled steel fibers together with shear ties at the interface of push-off specimens. The findings reveal that it is viable to replace two shear ties with one 8mm-2L shear tie and 1% crimped steel fibers of 30mm length.
Does pronator quadratus muscle tear in distal radius fractures affect patient outcomes? Analyses of 55 patients in a volar locking plate arm of a randomized clinical trial
Authors: Eikrem Morten , Lian Tom , Madsen Jan Erik , Figved Wender 
Published: March 2024

Abstract
Background:
The advantage of pronator quadratus (PQ) repair after internal fixation with the volar approach in distal radius fracture surgery has not been confirmed in the literature. The aim of this study was to compare grip strength, patient-reported outcomes and functional results between patients who had an intact PQ and patients who had a ruptured PQ before undergoing surgery with a volar locking plate for dorsally displaced unstable extra-articular distal radius fractures.
Methods:
A total of 120 patients aged 55 years and older were included in a randomized controlled trial comparing a volar locking plate with a dorsal nail plate. In 55 of 60 patients randomized to the volar plate group, the integrity of the pronator quadratus muscle was recorded during surgery. They were included in this study. The outcomes were the Quick Disabilities of the Arm, Shoulder and Hand Outcome Measure (QuickDASH) score, the Patient-Rated Wrist Evaluation (PRWE) score, EQ-5D index and visual analogue scale (VAS) score, grip strength and range of motion (ROM).
Results:
The median age was 67 years (55 to 88) and the 1-year follow-up rate was 98%.
Patients with an identified intact PQ (28/55) before surgical release had better QuickDASH scores after 1 year (2.5 vs 8.0, mean difference 5.5, 95% CI: 1.3 to 9.8, p=0.028). Patients in the intact group had better EQ-5D Index scores after 1 year (0.94 vs 0.85, mean difference 0.089, 95% CI: 0.004 to 0.174, p=0.031), and had better grip strength throughout the trial, after 1 year: 24 kg vs 20 kg (mean difference 3.9; 95% CI: 0.3 to 7.6, p=0.016). After 1 year the intact group had regained 96% of their grip strength and the nonintact group 93% of their grip strength compared to the uninjured side. The observed differences may be of questionable clinical importance, as they were lower than those of previously proposed MCIDs.
Conclusions:
Patients with a distal radius fracture and ruptured PQ prior to surgery had higher QuickDASH scores and lower EQ-5D index scores after 1 year. The integrity of the pronator quadratus should be reported in future studies.
Level of Evidence:
Therapeutic Level 2b: Follow-up of control patients in an RCT.
Realistic real-time processing of anime portraits based on generative adversarial networks
Authors: Zhu Gaofeng , Qu Zhiguo , Sun Le , Liu Yuming , Yang Jianfeng 
Published: March 2024

Abstract
Nowadays, more and more brands use interesting anime characters to promote and increase brand awareness. However, real-time and interesting promotional materials are also one of the key factors to attract people, so real-time processing of anime characters has also become an effective way to enhance brand awareness. In recent years, with the rapid development of deep learning, image style conversion based on AI technology has become a much-attended artificial intelligence application, but it also suffers from the disadvantages of complex model structure, slow conversion speed, and inconspicuous identity features, which need to be improved. In view of this, this paper proposes an Anime Portrait Realization (ARF-GAN) algorithm based on Generative Adversarial Network. This algorithm is based on the CGAN architecture and also uses the U-net network structure with jump connections to connect the encoder's feature maps directly to the decoder, which in turn enables the network to reconstruct the output data in a better way and the network architecture is more lightweight. It also introduces the CBAM module, which can enhance the model's expressive and generative capabilities without increasing the model's complexity, and improve the model's real-time image processing capability. In addition, this paper also compensates for the problem of image blurring brought by the original architecture by introducing the deblurring module. Based on Windows 10 environment and Python 3.7 programming language, and experiments on CartoonFace, DanBooru dataset show that the proposed ARF-GAN has a better generative effect for the task of realizing anime portraits, and comparing with different types of image generating models, it shows better accuracy and lower accuracy in several evaluation indexes such as PSNR, SSIM, and so on. better accuracy and lower time complexity. This makes it more suitable for brand advertisement promotion, so it has good application value for improving in brand awareness.
PARP14 inhibits the inflammatory response of macrophages through the NF-κB pathway
Authors: Guo Xuefei , Zhao Yang 
Published: March 2024

Abstract
The poly-ADP-ribose polymerase (PARP) superfamily consists of 17 members, which regulate many biological processes in physiological or pathological conditions, such as DNA damage repair, anti-viral responses, and development of adaptive immune cells. Among them, PARP14 is the biggest member, containing two RNA recognition motifs at the N-terminal, three macro-domains, one WWE domain, and one PARP domain at the C-terminal, which was reported to regulate IL4/STAT6 signaling in adaptive immune cells. However, whether PARP14 participates in regulatinghost inflammatory response remainsunclear. In a previous study, we observed that virus infection and LPS treatment induced the transcription of Parp14. By comparing the primary macrophages derived from Parp14 KO and WT mice, we found that some inflammatory cytokines were significantly induced in KO macrophages. Still, theexpression of Ifnb1 had no significant difference compared to the WT macrophages. RNA-seq analysis showed that the KO group had a more robustinflammatory response but a weaker innate immune response upon stimulation. We validated these results by performing a knockdownof Parp14 in RAW 264.7 cells. Moreover, the survival time of the KO mice was much shorter than that of the WT group upon LPS injection. Transcription factor enrichment analysis indicated that nuclear factor-kappaB1 (NF-κB1) may be the main reason for increasing the production of these inflammatory cytokines. As expected, the up-regulation wasdeleted upon the treatment of the inhibitor of NF-κB, JSH23. These data imply that PARP14 regulates inflammatory responses through the NF-κB pathway.
Good long-term results of sacral neuromodulation for endometriosis related chronic pelvic pain
Authors: Zegrea Adrian , Ojala Emilia , Kirss Jaan , Suvitie Pia , Varpe Pirita , Mäkelä-Kaikkonen Johanna , Rautio Tero , Seikkula Jaana , Ukkonen Mika , Lavonius Maija , Pinta Tarja 
Published: March 2024

Abstract
Background
Sacral neuromodulation (SNM) is an established therapy in urology and gastroenterological surgery for treatment of overactive bladder symptoms, urge urinary incontinence or fecal incontinence. SNM has also been used with good results in patients with chronic pelvic pain (CPP). Our aim was to analyze long-term results of SNM in Finnish patients with endometriosis related CPP.
Methods
This is a register-based retrospective study including all the endometriosis patients treated with SNM for CPP in Finland between 2004 and 2017. There were four centers where these procedures were performed, two University Hospitals and two Central Hospitals. Long-term results were assessed by phone interview in spring 2021.
Results
A total of 16 women with endometriosis, with a median age of 39 (25–50) years, underwent SNM treatment for chronic pelvic pain (CPP), with the median follow-up time of 73 (48–85) months. The Implantable Pulse Generator (IPG) was implanted to 14 patients (88%). By the end of the follow-up period, 10 patients (62,5% of all patients and 71% of those who received IPG) had a functional SNM. Pain was assessed by numeral rating scale (NRS) and decreased from a median of 7.4 (3.6–10) to 2.25 (0-6.5).
Conclusions
SNM could be a good option in the treatment of endometriosis related chronic pelvic pain when standard therapy is not enough.
Study on Solution Combustion Synthesis and Electrochemical Performance of V2O5-Cu as Cathode Materials for Aqueous Zinc-Ion Batteries
Authors: Ma Jidong , Gu Xinya , Du Kai , Zhou Wenjun , Cui Jian , Gu Siyong , Zhang Houan 
Published: March 2024

Abstract
Aqueous zinc-ion batteries (AZIBs) are considered to be one of the most promising alternative energy sources due to their safety. Vanadium-based compounds, especially V2O5 cathode materials, have been widely studied due to the advantages of suitable working voltage windows and highly reversible redox reactions. However, the poor conductivity of V2O5 and its structural instability limit its application in AZIBs. In this paper, copper ions doped V2O5 was synthesized by a simple one-step solution combustion synthesis method to improve its structural stability and electrochemical performance. The modified material expanded the interlayer spacing and increased the ionic diffusion rate, and increased the concentration of low valence vanadium and oxygen vacancy, thereby increasing the electron mobility and promoting the electrochemical reaction, resulting in an enhanced discharge specific capacity of the material. Zinc-ion batteries assembled with V2O5-Cu as the cathode material can provide a high discharge specific capacity of 300 mAh g− 1 at 4 A g− 1, and have good cycling stability, with a capacity retention of 95% over 500 cycles.
Down-regulation of miR-138-5p by PP2A promoted apoptosis of spermatocytes
Authors: Wang Danni , Liu Xing , Chen Bingyan , Shang Yuwei , Wan Ting , Zhang Shu , Liu Huijun , Shi Yichao , chen xia , Sun huiting 
Published: March 2024

Abstract

Background
Protein phosphatase 2A (PP2A) plays a critical and multifaceted role in numerous physiological processes. Previously, we generated germ cell specific knockout mice for the PP2A catalytic subunit alpha subunit (Ppp2cacKO) by the cre-loxp system.
Methods and results
Through high-throughput miRNA sequencing of testis tissues and real‑time PCR, we identified a significant decrease in the expression of miR-138-5p in the testes of Ppp2cacKO mice. Here, we report that miR-138-5p affects the apoptosis and proliferation of GC2 cells. Importantly, multiple database predictions suggest that miR-138- 5p may target the transcriptional repressor Trps1. Consistent with this finding, we observed a significant overexpression of Trps1 in the testes of Ppp2cacKO mice. In addition, by transfection experiments, we confirmed that miR-138-5p negatively regulated Trps1 expression in GC2 cells.
Conclusion
In study, our findings suggest that miR-138-5p may promote spermatocyte apoptosis by targeting Trps1 after PP2A enzyme dysfunction.
Dose prediction of CyberKnife Monte Carlo plan for lung cancer patients based on deep learning: robust learning of variable beam configurations
Authors: Miao Yuchao , Li Jiwei , Ge Ruigang , Xie Chuanbin , Liu Yaoying , Zhang Gaolong , Miao Mingchang , Xu Shouping 
Published: March 2024

Abstract

Background
Accurate calculation of lung cancer dose using the Monte Carlo (MC) algorithm in CyberKnife is essential for precise planning. We aim to employ deep learning to directly predict the 3D dose distribution calculated by the MC algorithm, enabling rapid and accurate automatic planning. However, most current methods solely focus on conventional intensity-modulated radiation therapy and assume a consistent beam configuration across all patients. This study seeks to develop a more versatile model incorporating variable beam configurations of CyberKnife and considering the patient's anatomy.
Methods
This study proposed the AB (anatomy and beam) model to compare with the control Mask (only anatomy) model. These models are based on a 3D U-Net network to investigate the impact of CyberKnife beam encoding information on dose prediction. The study collected 86 lung cancer patients who received the built-in MC algorithm plans of CyberKnife using different beam configurations for training/validation (66 cases) and testing (20 cases). We compared the gamma passing rate, dose difference maps, and relevant dose-volume metrics to evaluate the model's performance. In addition, the Dice similarity coefficients (DSCs) was calculated to assess the spatial correspondence of isodose volumes.
Results
The AB model demonstrated superior performance compared to the Mask model, particularly in the trajectory dose of the beam. The DSCs of the AB model was 20–40% higher than that of the Mask model in some dose regions. We achieved approximately 99% for the PTV and generally more than 95% for the organs at risk (OARs) referred to the clinical planning dose in the gamma passing rates (3mm/3%). Relative to the Mask model, the AB model exhibited more than 90% improvement in small voxels (P < 0.001). The AB model matched well with the clinical plan's dose-volume histograms (DVHs) and the average dose error for all organs was 1.65 ± 0.69%.
Conclusions
Our proposed new model signifies a crucial advancement in predicting CyberKnife 3D dose distributions for clinical applications. It enables planners to rapidly and precisely calculate MC doses for lung cancer based on patient-specific beam configurations.
Synergistic flame retardant behavior and mechanism of based on DOPS/triazine-trione groups flame retardants in epoxy resins
Authors: 宦 宣英 , Hou Zeming , Qi Yuzhao , Xu Qiu , Xu Songjiang , Ma Shikai , Bao Dongmei , Zhang Daohai , Zhou Guoyong , Zhang Yupeng , Wen Zhu 
Published: March 2024

Abstract

Epoxy resin (EP), as a widely used polymer material, is inherently flammable. Bestowing it with high-efficiency flame-retardant properties has always been the focus of attention. Herein, Using triallyl isocyanurate (TAIC) and 9,10-dihydro-9-oxa-10-phospha phenanthrene-10-sulfide (DOPS) as raw materials, a novel bismaleimide flame retardant, tris(3-(9,10-dihydro-9-oxa-0-phosphaphenanthrene-10-sulfide)-propyl)triazine-2,4,6-trione(DOPS-TAIC), was synthesized via a one-step method. Before curing, the structure was characterized using FT-IR, 1H NMR, and 31P NMR. Subsequently, the flame retardant DOPS-TAIC was applied to EP, and a series of testing methods were employed to investigate the effects of DOPS-TAIC on the thermal stability, flame retardancy, and mechanical properties of EP. Furthermore, the flame retardant mechanism of DOPS-TAIC in the gas phase and condensed phase was further explored. The results showed that EP/DOPS-TAIC achieved UL-94 V-0 rating with an LOI value of 31.6% when added at 12.5 wt%. In addition, the total heat release (THR), peak heat release rate (PHRR), and average heat release rate (av-HRR) of EP/DOPS-TAIC-12.5 wt% were significantly reduced by 35.05%, 61.83%, and 51.68%, respectively. The SEM-EDS results indicate that DOPS-TAIC can form a more complete and dense char layer, with a higher phosphorus content in the char layer. Meanwhile, TG-IR and Py-GC/MS demonstrate its radical quenching effect in the gas phase, indicating that DOPS-TAIC possesses both condensed-phase and gas-phase flame-retardant mechanisms. Therefore, this study provides a simple and effective method for developing flame-retardant epoxy resins.