bluuebunny/crossref_metadata_2025_split huggingface dataset:
Poor short-term outcomes for prognostic high-risk patients with chronic limb-threatening ischemia undergoing endovascular therapy
Authors: Takei Tatsuro , Kajiya Takashi , Ohura Norihiko , Tomimura Natsuko , Kamiyama Takuro , Ninomiya Toshiko , Takaoka Junichiro , Atsuchi Nobuhiko 
Published: March 2024

Abstract
Background
The prognosis of chronic limb-threatening ischemia (CLTI) is poor, with an expected life expectancy of 2 or more years, which significantly influences treatment decisions. However, death may occur at the early stages of treatment for wound healing, and aggressive treatment may limit the quality of life of such patients. In patients with CLTI undergoing endovascular therapy (EVT), the Wound, Ischemia, and foot Infection (WIfI) clinical stage, male sex, older age, non-ambulatory status, low body mass index, and dialysis have been reported as predictors of mortality risk. However, most studies have not fully investigated the WIFI clinical stage as a prognostic predictor of CLTI. This study aimed to evaluate short-term prognosis and wound healing rates using the prognostic predictors (PPs) indicated above in risk-stratified patients with CLTI who underwent EVT.

Methods
This retrospective single-center observational study included 61 CLTI patients undergoing EVT from April 2020 to October 2022. The patients were divided into a high-risk group (PPs ≥ 4, n = 20) and low-risk group (PPs ≤ 3, n = 41) according to the number of PPs. Survival and wound healing rates within one year were compared between these two groups.

Results
The mean age of the patients was 74.7 ± 1.6 years, and 42 (68.9%) were male. Among these patients, the high-risk group compared with the low-risk group had a significantly worse survival rate within one year (46.4% vs. 84.7%, log-rank p < 0.001). Fifteen patients died within one year. Of these, seven deaths were cardiovascular deaths and six were deaths from infectious diseases. Cox proportional hazards analysis showed that WIfI clinical stage 4 (p = 0.043, hazard ratio [HR] = 4.85) and the male sex (p = 0.037, HR = 6.34) influenced the prognosis of this population. The high-risk group tended to have a worse wound healing rate within one year than that had by the low-risk group (55.4% vs. 83.0%, log-rank p = 0.086).

Conclusions
The assessment of short-term prognosis and wound healing rates using PPs may be useful. Discussing the results of short-term clinical outcome assessments with patients should be considered when determining their individualized treatment plans.
Land use and meteorological influences on dengue transmission dynamics in Dhaka city, Bangladesh
Authors: Roy Sudipta , Biswas Abhijit , Shawon Mst. Tanzila Aktar , Akter Samia , Rahman Mohammad Mizanur 
Published: March 2024

Abstract
Background
Dengue fever, a viral illness spread mostly by Aedes mosquitoes, continues to pose a substantial public health issue in Dhaka city, Bangladesh. In Dhaka, climatic and socio-demographic factors like population density affect the spread of dengue. The dengue indexes are greatest in the residential mixed zone. Numerous environmental parameters, such as temperature, relative humidity, rainfall, and the air pollution index, have been linked to mosquito larvae, and dengue prevalence is correlated with urbanization, decreased vegetation, and population expansion.

Methods
By using an extensive dataset that encompasses a range of years, we use spatial and temporal analytic methodologies to investigate the correlation between land use attributes, climatic variables, and the occurrence of dengue fever. To better understand the dynamics of dengue, the built environment and climatic factors are treated as independent variables in this study. ArcPy is a Python package that facilitates here for geographic data analysis and ArcMap 10.7 also used for visualizing spatial data.

Results
The results of our study demonstrate that land use significantly influences the spatial patterns of Dengue incidence in Dhaka city. The dengue hotspot Thana are identified and these are Badda, Jatrabari, kadamtali, Mirpur, Mohammadpur, Sobujbagh, Shyampur, Tejgoan, Dhanmondi and Uttara. All of these areas’ population density and residential use as land use is higher than the other Thana of Dhaka city. There exists a significant correlation between climatic characteristics, such as temperature (0.25), rainfall (.803), specific humidity (0.74), relative humidity (0.76), wind speed (0.4) and Dengue incidence patterns. This research emphasizes the structural use and climatic relationship in Dengue epidemics, with climatic conditions playing a significant role as drivers of these variations.

Conclusions
This research demonstrates the complex relationship between land use, meteorological factors, and the spread of Dengue fever in Dhaka city. The results of this study have significant significance for several domains, including urban planning, public health measures, and vector control tactics. A comprehensive understanding of the temporal and geographical patterns of dengue transmission might aid in the development of accurate and effective prevention measures intended to lessen the effects of dengue in cities, such as Dhaka.
Ultrafast laser one-step construction of 3D micro-/nanostructures achieving high-performance zinc metal anodes
Authors: Liu Yanan , Ding Ye , Liu Zeping , Li Xingchen , Tian Sichao , Fan Lishuang , Xie Jichang , Xu Liangliang , Lee Jinwoo , Li Jian , Yang Lijun 
Published: March 2024

AbstractAqueous zinc-ion batteries provide a most promising alternative to the existing lithium-ion batteries due to their high theoretical capacity, intrinsic safety, and low cost. However, commercializing aqueous zinc-ion batteries suffer from dendritic growth and side reactions on the surface of metallic zinc, resulting in poor reversibility. To overcome this critical challenge, here, we report a one-step ultrafast laser processing method for fabricating three-dimensional micro-/nanostructures on zinc anodes to optimize zinc nucleation and deposition processes. It is demonstrated that the three-dimensional micro-/nanostructure with increased specific surface area significantly reduces nucleation overpotential, as well as preferentially absorbs zinc ions to prevent dendritic protuberances and corrosion. As a result, the presence of three-dimensional micro-/nanostructures on the zinc metal delivers stable zinc plating/stripping beyond 2500 h (2 mA cm-2/1 mAh cm-2) in symmetric cells, a high Coulombic efficiency (99.71%) in half cells, and moreover an improved capacity retention (71.8%) is also observed in full cells. Equally intriguingly, the pouch cell with three-dimensional micro-/nanostructures can operate across various bending states without severely compromising performance. This work provides an effective strategy to construct ultrafine and high-precision three-dimensional micro-/nanostructures achieving high-performance zinc metal anodes and is expected to be of immediate benefit to other metal-based electrodes.
Risk of Thyroid Cancer in People With Type 1 Diabetes by Autoimmune Thyroid Diseases and Tumor Histology
Authors: Mäkimattila Sari , Harjutsalo Valma , Feodoroff Maija , Groop Per-Henrik 
Published: March 2024

Abstract

Context
Thyroid cancer is the most common endocrine cancer, but little is known about it in type 1 diabetes (T1D) and its potential association with autoimmune diseases.

Objective
This study aims to assess the risk of thyroid cancer in adults with long-term T1D compared to individuals without diabetes and the proposed association of thyroid autoimmune diseases with thyroid cancer.

Methods
The study included 4758 individuals with T1D participating in the Finnish Diabetic Nephropathy Study and 12 710 controls. Thyroid cancers were obtained from the Finnish Care Registers for Health Care.

Results
27 (0.57%) individuals with T1D had thyroid cancer compared to 27 (0.21%) in the controls (standardized incidence ratio 2.43; 95% confidence interval 1.59-3.56). The absolute increase in incidence was modest, with a 0.36%-unit rise. This translates to 17 additional cases among 4710 individuals with T1D. Cancer type was papillary in 81.5% of individuals with T1D and 88.9% of the controls; the rest were follicular. In T1D the distribution of hypothyreosis was similar between those with (n = 5, 18.5%) and without (18.1%) cancer, but hyperthyreosis was diagnosed more often with thyroid cancer (n = 3, 11.1%) than without (2.3%, P = .003). None of the thyroid cancers were invasive or had metastatic characteristics.

Conclusion
Although there is an excess risk of thyroid cancer, it is only marginally increased (0.36%-unit) in individuals with T1D compared to control individuals and was not associated with increased morbidity or mortality. An overdiagnosis effect due to regular health care contacts is the most likely explanation for the higher risk.
The Grandchildren of Immigrants in Western Europe: Patterns of Assimilation Among the Emerging Third Generation
Authors: Zhao Linda , Drouhot Lucas G. 
Published: March 2024

Abstract
Migration scholars have long regarded the trajectory of the third generation as a critical test of assimilation; however, scholarship to date has been limited and largely focused on socioeconomic attainment. In this article, we rely on a large dataset of adolescent respondents in England, Germany, and the Netherlands to compare the second and third generations in terms of their social networks and cultural identities. The third generation shows stronger ties to the native fourth-plus generation alongside weaker ties to coethnics. We document comparable, albeit more moderate, dynamics of assimilation over generations in regard to national and ethnic identification, along with substantial variation by country of destination and ethnic origin group. Our results point to a dominant trend of assimilation at the third generation and suggest future challenges to provide a more durable assessment of postwar migration waves two generations after settlement.
Who Is They?
Authors: Ultra Omni Victor , Harris Laura Alexandra 
Published: March 2024

Abstract
At the heart of this project is an intergenerational dialogue, an elliptical tracing of languages and communities in their acts of reclaiming and renaming. In this dialogue the authors ask how does a linguistic archive of Black queer/trans culture, in particular the grammars of they, kiki/Ky-Ky, and fem and stud travel within and shape language and expressive culture? If the Black queer and Black vernacular overlap, how do we look to the creative influences of Black queer and Black trans historical symmetries and exchanges? Reexamining historical continuities and shared socialities of Black gender genealogies, the authors refuse the scholarly impetus to discover “new” nonbinary and transgender frontiers when Black working-class vernacular culture has always structured and enabled radical linguistic expression and gendered possibilities. Writing together, the authors transfigure intergenerational knowledges into a critical theory repositioning the terms of the debate and enabling possibilities for connections where there have only been closures. Talking Black to talk back to this current moment of ever-expanding gender narratives, the authors look toward Black epistemologies conveniently forgotten in current discourses of pluralized gender subjectivities.
Juliana Huxtable's Cow-Woman; or, A Black Trans Femme Route Toward Pleasure
Authors: Wolf Lillian 
Published: March 2024

Abstract
In this article, the author focuses on Juliana Huxtable's (2019) exhibition Interfertility Industrial Complex: Snatch the Calf Back to theorize a Black trans affective posture toward pleasure. Contextualizing Huxtable's artistry within histories of Black feminine reproductive control, the author demonstrates how Huxtable's invented hybrid figure of the cow-woman builds a Black trans femme perspective on reproduction, which exceeds gendered capacity and bio-reproducibility. Then the author moves to analyze Huxtable's intimate account of learning how to perform bovine animal husbandry on a family farm. This account demonstrates a close embodied attunement that seeks to elicit pleasure for both the heifer as well as the farmer. The author analyzes how this relationship articulates a reproductive coalitional politic that crosses species as well as time. Throughout, the author draws on Black feminist theory, as well as trans and queer approaches to interspecies studies, to articulate how Huxtable's artistry offers a strategy for navigating the complex structures and relations that emerge from feelings of pleasure.
Outcomes of Hepatic Artery-Based Therapies and Systemic Multiagent Chemotherapy in Unresectable Colorectal Liver Metastases: A Systematic Review and Meta-analysis
Authors: Sugumar Kavin , Stitzel Henry , Wu Victoria , Bajor David , Chakrabarti Sakti , Conces Madison , Henke Lauren , Lumish Melissa , Mahipal Amit , Mohamed Amr , Winter Jordan M. , Hardacre Jeffrey M. , Ammori John B. , Selfridge Jennifer E. , Ocuin Lee M. 
Published: March 2024

Abstract
Background
Treatment of unresectable colorectal liver metastases (UCRLM) includes locoregional and systemic therapy. A comprehensive analysis capturing long-term outcomes of these treatment options has not been performed.

Objective
A systematic review and meta-analysis was performed to calculate pooled outcomes of hepatic artery infusion with systemic chemotherapy (HAI-S), transarterial chemoembolization with systemic chemotherapy (TACE-S), transarterial radioembolization with systemic chemotherapy (TARE-S), doublet (FOLFOX, FOLFIRI), and triplet chemotherapy (FOLFOXIRI).

Methods
Outcomes included overall survival (OS), progression-free survival (PFS), rate of conversion to resection (CTR), and response rate (RR).

Results
A total of 32, 7, 9, and 14 publications were included in the HAI-S, TACE-S, and TARE-S chemotherapy arms. The 6/12/24/36-month OS estimates for HAI-S, TACE-S, TARE-S, FOLFOX, FOLFIRI, and FOLFOXIRI were 97%/80%/54%/35%, 100%/83%/40%/14%, 82%/61%/34%/21%, 96%/83%/53%/36%, and 96%/93%/72%/55%. Similarly, the 6/12/24/36-month PFS estimates were 74%/44%/19%/14%, 66%/20%/9%/3%, 57%/23%/10%/3%, 69%/30%/12%/7%, and 88%/55%/18%/11%. The corresponding CTR and RR rates were 31, 20%, unmeasurable (TARE-S), 35, 53; and 49, 45, 45, 50, 80%, respectively. The majority of chemotherapy studies included first-line therapy and liver-only metastases, whereas most HAI-S studies were pretreated. On subgroup analysis in first-line setting with liver-only metastases, the HAI-S arm had comparable outcomes to FOLFOXIRI and outperformed doublet chemotherapy regimens. Although triplet chemotherapy appeared to outperform other arms, high toxicity and inclusion of potentially resectable patients must be considered while interpreting results.

Conclusions
HAI-S and multiagent chemotherapy are effective therapies for UCRLM. To make definitive conclusions, a randomized trial with comparable patient characteristics and line of therapy will be required. The upcoming EA2222 PUMP trial may help to address this question.
Multiple instance learning framework can facilitate explainability in murmur detection
Authors: Rohr Maurice , Müller Benedikt , Dill Sebastian , Güney Gökhan , Hoog Antink Christoph 
Published: March 2024

Objective
Cardiovascular diseases (CVDs) account for a high fatality rate worldwide. Heart murmurs can be detected from phonocardiograms (PCGs) and may indicate CVDs. Still, they are often overlooked as their detection and correct clinical interpretation require expert skills. In this work, we aim to predict the presence of murmurs and clinical outcomes from multiple PCG recordings employing an explainable multitask model.

Approach
Our approach consists of a two-stage multitask model. In the first stage, we predict the murmur presence in single PCGs using a multiple instance learning (MIL) framework. MIL also allows us to derive sample-wise classifications (i.e. murmur locations) while only needing one annotation per recording (“weak label”) during training. In the second stage, we fuse explainable hand-crafted features with features from a pooling-based artificial neural network (PANN) derived from the MIL framework. Finally, we predict the presence of murmurs and the clinical outcome for a single patient based on multiple recordings using a simple feed-forward neural network.

Main results
We show qualitatively and quantitatively that the MIL approach yields useful features and can be used to detect murmurs on multiple time instances and may thus guide a practitioner through PCGs. We analyze the second stage of the model in terms of murmur classification and clinical outcome. We achieved a weighted accuracy of 0.714 and an outcome cost of 13612 when using the PANN model and demographic features on the CirCor dataset (hidden test set of the George B. Moody PhysioNet challenge 2022, team “Heart2Beat”, rank 12 / 40).

Significance
To the best of our knowledge, we are the first to demonstrate the usefulness of MIL in PCG classification. Also, we showcase how the explainability of the model can be analyzed quantitatively, thus avoiding confirmation bias inherent to many post-hoc methods. Finally, our overall results demonstrate the merit of employing MIL combined with handcrafted features for the generation of explainable features as well as for a competitive classification performance.
Barriers and facilitators to the delivery of age-friendly health services in Primary Health Care centres in southwest, Nigeria: A qualitative study
Authors: Ogunyemi Adedoyin O. , Balogun Mobolanle R. , Ojo Adedayo E. , Welch Sarah B. , Onasanya Oluwatosin O. , Yesufu Victoria O. , Omotayo Abisola T. , Hirschhorn Lisa R. 
Published: March 2024

Background
With the rapid growth of Nigeria’s older population, it has become important to establish age-friendly healthcare systems that support care for older people. This study aimed to explore the barriers and facilitators to the delivery of age-friendly health services from the perspectives of primary healthcare managers in Lagos State, Nigeria.

Method
We conducted 13 key informant interviews including medical officers of health, principal officers of the (Primary Health Care) PHC Board and board members at the state level. Using a grounded theory approach, qualitative data analysis was initially done by rapid thematic analysis followed by constant comparative analysis using Dedoose software to create a codebook. Three teams of two coders each blind-coded the interviews, resolved coding discrepancies, and reviewed excerpts by code to extract themes.

Results
The main barriers to the delivery of age-friendly services included the lack of recognition of older adults as a priority population group; absence of PHC policies targeted to serve older adults specifically; limited training in care of older adults; lack of dedicated funding for care services for older adults and data disaggregated by age to drive decision-making. Key facilitators included an acknowledged mission of the PHCs to provide services for all ages; opportunities for the enhancement of older adult care; availability of a new building template that supports facility design which is more age-friendly; access to basic health care funds; and a positive attitude towards capacity building for existing workforce.

Conclusion
While we identified a number of challenges, these offer opportunities to strengthen and prioritize services for older adults in PHCs and build on existing facilitators. Work is needed to identify and test interventions to overcome these challenges and improve the responsiveness of the PHC system to older adults through the delivery of age-friendly health services in PHCs in Lagos, Nigeria.
The relationship between gender discrimination and wellbeing in middle-aged and older women
Authors: Hackett Ruth A. , Hunter Myra S. , Jackson Sarah E. 
Published: March 2024

Background
Emerging evidence suggests that perceived gender discrimination negatively impacts mental wellbeing in young women.

Purpose
This study explored whether a similar relationship exists in middle-aged and older women.

Methods
A total of 3081 women (aged ≥52 years) from the English Longitudinal Study of Ageing provided data on perceived gender discrimination in 2010/11. Depressive symptoms, loneliness, quality of life and life satisfaction were assessed in 2010/11 and in 2016/17.

Results
Perceived gender discrimination was reported by 282 (9.2%) participants. Cross-sectionally, women who perceived gender discrimination reported more depressive symptoms (β = 0.34, 95% CI 0.11 to 0.57) and had higher loneliness scores (β = 0.14, 95% CI 0.08 to 0.20) than women who did not perceive gender discrimination. They also reported significantly lower quality of life (β = −2.50, 95% CI −3.49 to −1.51) and life satisfaction (β = −1.07, 95% CI −1.81 to −0.33). Prospectively, perceived gender discrimination was associated with greater loneliness scores (β = 0.08, 95% CI 0.02 to 0.14), as well as lower ratings of quality of life (β = −0.98, 95% CI −0.09 to −1.86), and life satisfaction (β = −1.04, 95% CI −0.34 to −1.74), independent of baseline values.

Conclusions
Middle-aged and older women who perceive gender discrimination report poorer mental wellbeing than those who do not perceive discrimination. Further, this type of discrimination may be predictive of declining mental wellbeing over time. These findings highlight the need for interventions to target gender-based discrimination to improve the wellbeing of women at mid- and older age.
Causal effect of porphyria biomarkers on alcohol-related hepatocellular carcinoma through Mendelian Randomization
Authors: Yang Xiaoyu , Wang Shuomin , Sun Chen , Xia Yunhong 
Published: March 2024

Purpose
According to some cohort studies, an association exists between acute intermittent porphyria (AIP) and liver cancer. However, establishing a definitive causal relationship between porphyria and hepatocellular carcinoma (HCC) remains challenging. Prexisting studies regarding porphyria biomarkers and alcohol-related hepatocellular carcinoma (AR-HCC) make possible an entry point. In this study, we aimed to investigate the causal relationships between biomarkers of two types of porphyria, AIP and congenital erythropoietic porphyria (CEP), and AR-HCC.

Methods
Single-nucleotide polymorphisms (SNPs) associated with porphobilinogen deaminase (PBGD) and uroporphyrinogen-III synthase (UROS), along with outcome data on AR-HCC, were extracted from public genome-wide association studies (GWAS). The GWAS data were then used to explore the potential causal relationships via a two-sample Mendelian randomization (MR) analysis. The effect estimates were calculated using the random-effect inverse-variance-weighted (IVW) method. Additionally, the Cochrane’s Q test, MR-Egger test, and leave-one-out analysis were conducted to detect heterogeneity and pleiotropy in the MR results.

Results
Using the IVW method as the primary causal effects model in the MR analyses, we found that both PBGD (effect estimate = 1.51; 95% CI, from 1.08 to 2.11, p = 0.016) and UROS (effect estimate = 1.53; 95% CI, from 1.08 to 2.18, p = 0.018) have a significant causal effect on AR-HCC.

Conclusion
Our findings revealed a causal effect of both PBGD and UROS on AR-HCC, suggesting that both AIP and CEP have a causal association with AR-HCC.
The Men Who Would Be King, Jon Tonks (Photographs) and Christopher Lord (Text) (2021)
Authors: Lindstrom Lamont 
Published: March 2024

Review of: The Men Who Would be King, Jon Tonks (Photographs) and Christopher Lord (Text) (2021)
Stockport: Dewi Lewis Publishing, 200 pp.,
ISBN 978 1 91130 643 6 (hbk), £39.00
Hundertwasser in New Zealand: The Art of Creating Paradise, Andreas J. Hirsch (2022), Translated by Uta Hoffmann
Authors: Bell Leonard 
Published: March 2024

Review of: Hundertwasser in New Zealand: The Art of Creating Paradise, Andreas J. Hirsch (2022), Translated by Uta Hoffmann
Auckland: Oratia Books, 240 pp.,
ISBN 978 1 99004 214 0 (hbk), NZ$70.00