bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel surgical method for treating fractures of the middle third of the clavicle
Authors: Liu Yayun , Tang Xiaozheng , Ding Yuanjun , Li Jingtang 
Published: March 2024

BACKGROUND: The clavicle is recognized as the bone most vulnerable to fractures. Moreover, approximately 80% of fractures occur in the middle third of the clavicle. Conservative treatment is associated with a higher rate of nonunion, while surgical treatment of fracture via internal fixation may have a variety of postoperative complications. Therefore, to improve patient satisfaction and reduce the complications related to internal fixation techniques, we modified the surgical approach to external fixation. OBJECTIVE: The purpose of this study was to assess the modified intervention’s prospects for clinical application. METHODS: A total of 36 patients with middle clavicle fractures were treated with screw–rod external fixation between April 2015 and October 2019. We observed the operative time, intraoperative blood loss, length of hospital stay, and fracture healing time. The patients were followed up regularly, and the clinical efficacy of the modified intervention was evaluated. Finally, the patients’ shoulder function was assessed based on the disabilities of the arm, shoulder, and hand (DASH) score. RESULTS: For the screw–rod external fixation, the mean operative time was found to be 48.6 ± 6.8 min, the intraoperative blood loss was 30.6 ± 17.2 mL, the length of hospital stay was 4.5 ± 1.5 days, and the fracture healing time was 2.8 ± 0.4 months. Eventually, all the patients healed well, with the combined “excellent” and “good” rate of shoulder function being assessed to be as high as 94.44%. Furthermore, the DASH scores were all less than 10, with the average score being 4.65 ± 3.34. CONCLUSIONS: The screw–rod external fixation technique offers the advantages of convenience, reliability, and good aesthetics, suggesting that it could be used as an alternative treatment method for fractures of the middle third of the clavicle.
B-HPD: Bagging-based hybrid approach for the early diagnosis of Parkinson’s disease1
Authors: Kumari Ritika , Singh Jaspreeti , Gosain Anjana 
Published: March 2024

Parkinson’s disease (PD) is a neurodegenerative condition that affects the neurological, behavioral, and physiological systems of the brain. According to the most recent WHO data, 0.51 percent of all fatalities in India are caused by PD. It is a widely recognized fact that about one million people in the United States suffer from PD, relative to nearly five million people worldwide. Approximately 90% of Parkinson’s patients have speech difficulties. As a result, it is crucial to identify PD early on so that appropriate treatment may be determined. For the early diagnosis of PD, we propose a Bagging-based hybrid (B-HPD) approach in this study. Seven classifiers such as Random Forest (RF), Decision Tree (DT), Logistic Regression (LR), Naïve Bayes (NB), K nearest neighbor (KNN), Random Under-sampling Boost (RUSBoost) and Support Vector Machine (SVM) are considered as base estimators for Bagging ensemble method and three oversampling techniques such as Synthetic Minority Oversampling Technique (SMOTE), Adaptive Synthetic (ADASYN) and SVMSmote are implemented under this research work. Feature Selection (FS) is also used for data preprocessing and further performance enhancement. We obtain the Parkinson’s Disease classification dataset (imbalanced) from the Kaggle repository. Finally, using two performance measures: Accuracy and Area under the curve (AUC), we compare the performance of the model with ALL features and with selected features. Our study suggests bagging with a base classifier: RF is showing the best performance in all the cases (with ALL features: 754, with FS: 500, with three Oversampling techniques) and may be used for PD diagnosis in the healthcare industry.
Warm Autoimmune Hemolytic Anemia with Chronic Hepatitis B
Authors: Wahyudi Adefri , Fadrian  , Afriant Rudy 
Published: March 2024

Introduction: Warm autoimmune hemolytic anemia (wAIHA) is caused by erithrocytes destruction by IgG or IgG plus C3d-mediated autoantibody. Long use steroids are first line therapy of wAIHA. It has risk infection reactivation, like chronic hepatitis B. Case report: Man, 64 y.o, hospitalized with diagnosis wAIHA and chronic hepatitis B. Diagnosis of wAIHA is built by: severe normocytic normochromic anemia, reticulocytosis 42.29%, increasing lactate dehydrogenase 397 U/L, direct Coombs test (+4), antibody screening IgG (+4). Anothers laboratorium findings: HbsAg (+), albumin 3.5 g/dL, ALT U/L, rapid HIV (-), anti HCV (-). There is no blast found in peripheral blood and bone marrow smear. Patient also diagnosed chronic hepatitis B inactive phase with negative HbeAg, HBV DNA 547 IU/L, normal liver finding in abdominal USG and moderate fibrosis from fibroscan. Washed red cell transfussion was administered, 2 x 125 mg methilprednisolone iv (3 days) tapering off until to 40 mg/day doses. He did not get antiviral prophylaxis and be planned to reevaluate in next 6 months. Conclusion: Steroid is first line therapy in wAIHA. When wAIHA is diagnosed, determination of chronic hepatitis B status should confirmed. There is a risk of reactivation of chronic hepatitis B infection so monitoring is needed.
Review Article: Characteristics of Ovarian Cancer: Age, Epithelial Histopathology, Stages
Authors: Laksmi Subhika , Rivany Riza , Edianto Deri , Rifsal Siregar Denny 
Published: March 2024

Introduction: Ovarian cancer is a disease that has a high mortality rate, it has 185 thousand deaths in 2018. In Indonesia, it is estimated that there are 100 cancer patients per 100 thousand people. Ovarian cancer is a malignancy with no specific symptoms, as a result advanced stage is commonly found at diagnosis and there is no effective screening test to date. However, genetic factors have been found to play a role in this disease. Objective: The aim of this study is to find out the characteristics of ovarian cancer patients. Methods: This research uses a review article research design, with a narrative type. Data collection was taken from a collection of journals sourced from Pubmed and met the inclusion and exclusion criteria set by the author and then summarized. Discussion: Six journals that included the characteristics of ovarian cancer patients are included in this review article. Results: According to the six journals, the mean age is 54 years old, the most stage found is stage 3, and the most epithelial histopathology found is serous. Conclusion: According to the six journals that were reviewed, the characteristics of ovarian cancer patients based on age, stage, and epithelial histopathology were found to be consistent with the theory that has been established.
PROTECCIÓN DE VARIEDAES CRIOLLAS DE USO COMÚN DE CHAYOTES MEXICANOS
Authors: Cadena-Iñiguez J. 
Published: March 2024

Los Recursos Fitogenéticos para la Alimentación y la Agricultura (RFAA) proporcionan beneficios para el ser humano y constituyen la base para el fitomejoramiento clásico, asistido y participativo, con el fin de incrementar la calidad, productividad y estabilidad de los sistemas de subsistencia.
â€œItâ€™s Not Just Fashion For Fashionâ€™s Sakeâ€ : Sustainable Fashion Social Media Influencer Ecosystem
Authors: Harrison Brooke 
Published: March 2024

<p>Globally we are witnessing the environmental demise of our planet. Simultaneously, consumers have shown a greater interest in shopping second-hand and the sustainable fashion industry is experiencing rapid growth, which is estimated to reach $8.25 billion by 2031 (Businesswire, 2020). This market acceleration led to the exploration of sustainable fashion social media influencers.Â </p>
<p>Using semi-structured interviews with 20 sustainable fashion social media influencers, the research analyzes the ecosystem of sustainable fashion social media influencers and makes three unique contributions. First, the research introduces a three-part typology of sustainable fashion social media influencers: 1) <em>sustainable lifestyle influencers</em>, 2) <em>sustainability influencers</em>, and 3) <em>thrifting influencers</em>. Second, the research uncovers how sustainable fashion social media influencers perform vulnerability and sustainability failures in a strategy to portray curated authenticity. Finally, the research identifies â€œthe entrepreneurial dichotomy,â€ which refers to the challenge that sustainable fashion influencers face when they harmonize their ethos of sustainability and ethics along with their desire to leverage their social media platforms for profit.Â </p>
SOSIALISASI KESEHATAN REPRODUKSI DI SEKOLAH MENENGAH ATAS NEGERI 1 SOROPIA
Authors: Yamin  , Malina Rachma , Finaya Azzahra Andi , Septia Arnika , Masrul Muhammad Alan Febrian , Wiranti Nada Eka , Ardhani Novia 
Published: March 2024

Kesehatan reproduksi remaja merupakan suatu kondisi yang sehat pada sistem, fungsi dan proses reproduksi pada remaja termasuk sehat secara mental serta sosial kultural. Menjaga kesehatan reproduksi pada masa remaja sangat penting, karena pada masa ini organ-organ seksual remaja telah aktif sehingga perlu mengetahui resiko apa saja yang dapat terjadi jika tidak memperhatikan kesehatan reproduksi. Tujuan dari kegiatan ini dimaksudkan untuk memberikan edukasi dan pengetahuan mengenai kesehatan reproduksi remaja serta hal-hal yang dapat membahayakan diri jika tidak menjaga kesehatan reproduksi pada siswa(i) SMAN 1 Soropia. Metode yang diberikan dalam pelaksanaan pengabdian ini berupa sosialisasi (pemamparan materi), poster yang ditempelkan dan leaflet yang dibagikan saat soasialisai, Dilakukan tanya-jawab pada akhir sesi pengadian untuk melihat tingkat pengetahuan siswa setelah mendapatkan materi sosialisasi. Hasil dari kegiatan pengabdian yang telah dilakukan yaitu bertambahnya pengetahuan Siswa/Siswi SMA Satu Negeri Soropia tentang Kesehatan reproduksi remaja dan mendapatkan informasi yang jelas mengenai Kesehatan reproduksi remaja.
Causal relationship between immune cells and prostate cancer: a Mendelian randomization study
Authors: Ye Zhipeng , Deng Xinpei , Zhang Jinhui , Shao Ruonan , Song Cailu , Zhao Jianfu , Tang Hailin 
Published: March 2024

Introduction:Despite the abundance of research indicating the participation of immune cells in prostate cancer development, establishing a definitive cause-and-effect relationship has proven to be a difficult undertaking.Methods:This study employs Mendelian randomization (MR), leveraging genetic variables related to immune cells from publicly available genome-wide association studies (GWAS), to investigate this association. The primary analytical method used in this study is inverse variance weighting (IVW) analysis. Comprehensive sensitivity analyses were conducted to assess the heterogeneity and horizontal pleiotropy of the results.Results:The study identifies four immune cell traits as causally contributing to prostate cancer risk, including CD127- CD8+ T cell %CD8+ T cell (OR = 1.0042, 95%CI:1.0011–1.0073, p = 0.0077), CD45RA on CD39+ resting CD4 regulatory T cell (OR = 1.0029, 95%CI:1.0008–1.0050, p = 0.0065), CD62L− Dendritic Cell Absolute Count (OR = 1.0016; 95%CI:1.0005–1.0026; p = 0.0039), CX3CR1 on CD14+ CD16− monocyte (OR = 1.0024, 95%CI:1.0007–1.0040, p = 0.0060). Additionally, two immune cell traits are identified as causally protective factors: CD4 on monocyte (OR = 0.9975, 95%CI:0.9958–0.9992, p = 0.0047), FSC-A on plasmacytoid Dendritic Cell (OR = 0.9983, 95%CI:0.9970–0.9995, p = 0.0070). Sensitivity analyses indicated no horizontal pleiotropy.Discussion:Our MR study provide evidence for a causal relationship between immune cells and prostate cancer, holding implications for clinical diagnosis and treatment.
Integrative analysis of bioinformatics and machine learning to identify cuprotosis-related biomarkers and immunological characteristics in heart failure
Authors: Tu Dingyuan , Xu Qiang , Luan Yanmin , Sun Jie , Zuo Xiaoli , Ma Chaoqun 
Published: March 2024

BackgroundsCuprotosis is a newly discovered programmed cell death by modulating tricarboxylic acid cycle. Emerging evidence showed that cuprotosis-related genes (CRGs) are implicated in the occurrence and progression of multiple diseases. However, the mechanism of cuprotosis in heart failure (HF) has not been investigated yet.MethodsThe HF microarray datasets GSE16499, GSE26887, GSE42955, GSE57338, GSE76701, and GSE79962 were downloaded from the Gene Expression Omnibus (GEO) database to identify differentially expressed CRGs between HF patients and nonfailing donors (NFDs). Four machine learning models were used to identify key CRGs features for HF diagnosis. The expression profiles of key CRGs were further validated in a merged GEO external validation dataset and human samples through quantitative reverse-transcription polymerase chain reaction (qRT-PCR). In addition, Gene Ontology (GO) function enrichment, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment, and immune infiltration analysis were used to investigate potential biological functions of key CRGs.ResultsWe discovered nine differentially expressed CRGs in heart tissues from HF patients and NFDs. With the aid of four machine learning algorithms, we identified three indicators of cuprotosis (DLAT, SLC31A1, and DLST) in HF, which showed good diagnostic properties. In addition, their differential expression between HF patients and NFDs was confirmed through qRT-PCR. Moreover, the results of enrichment analyses and immune infiltration exhibited that these diagnostic markers of CRGs were strongly correlated to energy metabolism and immune activity.ConclusionsOur study discovered that cuprotosis was strongly related to the pathogenesis of HF, probably by regulating energy metabolism-associated and immune-associated signaling pathways.
Renal hyperparathyroidism- a risk factor in the development of encapsulating peritoneal sclerosis
Authors: Moinuddin Zia , Wang Kelvin , Fullwood Catherine , Wiredu Elizabeth , Hutchison Alastair , Vardhan Anand , Herrick Sarah E. , Summers Angela , Augustine Titus , van Dellen David 
Published: March 2024

BackgroundEncapsulating peritoneal sclerosis (EPS) is a rare complication of prolonged peritoneal dialysis (PD) exposure, characterised by peritoneal thickening, calcification, and fibrosis ultimately presenting with life-threatening bowel obstruction. The presence or role of peritoneal calcification in the pathogenesis of EPS is poorly characterised. We hypothesise that significantly aberrant bone mineral metabolism in patients on PD can cause peritoneal calcification which may trigger the development of EPS. We compared the temporal evolution of bone mineral markers during PD in EPS patients with non-EPS long-term PD controls.MethodsLinear mixed model and logistic regression analysis were used to compare four-monthly serum levels of calcium, phosphate, parathyroid hormone, and alkaline phosphatase (ALP) over the duration of PD exposure in 46 EPS and 46 controls (PD, non-EPS) patients.ResultsEPS patients had higher mean calcium (2.51 vs. 2.41 mmol/L) and ALP (248.00 vs. 111.13 IU/L) levels compared with controls (p=0.01 and p&lt;0.001 respectively, maximum likelihood estimation). Logistic regression analysis demonstrated that high serum calcium and phosphate levels during PD were associated with a 4.5 and 2.9 fold increase in the risk of developing EPS respectively.ConclusionHigh levels of calcium and phosphate in patients on PD were identified to be risk factors for EPS development. Possible reasons for this may be an imbalance of pro-calcifying factors and calcification inhibitors promoting peritoneal calcification which increases peritoneal stiffness. Mechanical alterations may trigger, unregulated fibrosis and subsequent development of EPS. Improved management of secondary hyperparathyroidism during PD may ultimately diminish the EPS risk.
Low thyroxine serves as an upstream regulator of ecophysiological adaptations in Ansell’s mole-rats
Authors: Gerhardt Patricia , Begall Sabine , Frädrich Caroline , Renko Kostja , Heinrich Alexandra , Köhrle Josef , Henning Yoshiyuki 
Published: March 2024

IntroductionAbout 10% of all rodent species have evolved a subterranean way of life, although life in subterranean burrows is associated with harsh environmental conditions that would be lethal to most animals living above ground. Two key adaptations for survival in subterranean habitats are low resting metabolic rate (RMR) and core body temperature (Tb). However, the upstream regulation of these traits was unknown thus far. Previously, we have reported exceptionally low concentrations of the thyroid hormone (TH) thyroxine (T4), and peculiarities in TH regulating mechanisms in two African mole-rat species, the naked mole-rat and the Ansell’s mole-rat.MethodsIn the present study, we treated Ansell’s mole-rats with T4 for four weeks and analyzed treatment effects on the tissue and whole organism level with focus on metabolism and thermoregulation.ResultsWe found RMR to be upregulated by T4 treatment but not to the extent that was expected based on serum T4 concentrations. Our data point towards an extraordinary capability of Ansell’s mole-rats to effectively downregulate TH signaling at tissue level despite very high serum TH concentrations, which most likely explains the observed effects on RMR. On the other hand, body weight was decreased in T4-treated animals and Tb was upregulated by T4 treatment. Moreover, we found indications of the hypothalamus-pituitary-adrenal axis potentially influencing the treatment effects.ConclusionTaken together, we provide the first experimental evidence that the low serum T4 concentrations of Ansell’s mole-rats serve as an upstream regulator of low RMR and Tb. Thus, our study contributes to a better understanding of the ecophysiological evolution of the subterranean lifestyle in African mole-rats.
Comparison of neoadjuvant chemotherapy response and prognosis between HR-low/HER2-negative BC and TNBC: an exploratory real-world multicentre cohort study
Authors: Peng Jing , Hong Yue , Chen Qitong , Xu Feng , Zhang Danhua , Yao Jia , Zou Qiongyan , Yuan Liqin , Li Lun , Long Qian , Liao Liqiu , Liu Mingwen , Liu Xuan , Wang Shouman , Yi Wenjun 
Published: March 2024

ObjectiveHormone receptor (HR)-low/HER2-negative breast cancers (BCs) are more likely to be basal-like BCs, with similar molecular features and gene expression profiles to HR-negative (estrogen receptor &lt;1% or negative and progesterone receptor &lt;1% or negative) BCs. Recently, with the clinical application of adjuvant intensive therapy for triple-negative breast cancer (TNBC), the prognosis of TNBC patients without pathological complete response (pCR) has significantly improved. Therefore, it is necessary to reanalyse the prognostic characteristics of clinically high-risk HR-low/HER2-negative BC.MethodsAccording to the inclusion and exclusion standards, 288 patients with HR-low/HER2-negative BC and TNBC who received NAC and were followed up between 2015 and 2022 at three breast centres in Hunan Province, China, were enrolled. Inverse probability of treatment weighting (IPTW) was utilized to mitigate imbalances in baseline characteristics between the HR-low/HER2-negative BC group and TNBC group regarding event-free survival (EFS) and overall survival (OS). The primary clinical endpoints were pCR and EFS, while the secondary endpoints included OS, objective response rate (ORR), and clinical benefit rate (CBR).ResultsThe pCR rate (27.1% vs. 28.0%, P = 1.000), ORR rate (76.9% vs. 78.3%, P = 0.827) and CBR rate (89.7% vs. 96.5%, P = 0.113) after NAC were similar between the HR-low/HER2-negative BC and the TNBC group. EFS in patients with non-pCR from the 2 groups was significantly inferior in comparison to patients with pCR (P = 0.001), and the 3-year EFS was 94.74% (95% CI = 85.21% to 100.00%) and 57.39% (95% CI =43.81% to 75.19%) in patients with pCR and non-pCR from the HR-low/HER2-negative BC group, respectively, and 89.70% (95% CI = 82.20% to 97.90%) and 69.73% (95% CI = 62.51% to 77.77%) in the TNBC patients with pCR and non-pCR, respectively.ConclusionsIn the real world, the therapeutic effects of NAC for HR-low/HER2-negative BCs and TNBCs were similar. EFS of patients with non-pCR in the HR-low/HER2-negative BC group was inferior to that of the TNBC group with non-pCR, suggesting that it is necessary to explore new adjuvant intensive therapy strategies for these patients.
Association between lactate dehydrogenase and the risk of diabetic kidney disease in patients with type 2 diabetes
Authors: Tang Linqiao , Yang Qianyu , Ma Rong , Zhou Ping , Peng Cong , Xie Chunpeng , Liang Qiyuan , Wu Tingyu , Gao Wuyu , Yu Haiyan , Deng Guifei , Dai Zhen , Mao Nan , Xiao Xiang 
Published: March 2024

ObjectiveThis study aims to investigate the association between lactate dehydrogenase (LDH) and the risk of diabetic kidney disease (DKD) in patients with type 2 diabetes (T2D).MethodsThe study enrolled patients with diagnosis of T2D between 2009 and 2018 from the National Nutrition and Health Examination Survey (NHANES) database. Demographic information, laboratory test, and diagnostic data were collected. Restricted cubic spline (RCS) plots were used to assess the dose-effect relationship between LDH levels and the risk of DKD in patients with T2D. Based on LDH levels, individuals were divided into higher and lower groups using dichotomy, and multivariate logistic regression analysis was conducted to explore the relationship between different LDH levels and the risk of DKD in T2D patients. Stratified analysis was performed to assess the consistency of the result.ResultsA total of 4888 patients were included in the study, with 2976 (60.9%) patients without DKD and 1912 (39.1%) patients with DKD. RCS plots showed that the risk of DKD increased with increasing LDH levels. Multifactorial logistic regression analysis revealed that T2D patients with higher LDH levels had a 45% increased risk of DKD compared to those with lower LDH levels (OR=1.45; 95% CI: 1.11-1.89). Furthermore, each standard deviation increase in LDH level was associated with a 24% increase in DKD incidence among T2D patients (OR=1.24; 95% CI: 1.07-1.44). Stratified analysis consistently supported these findings.ConclusionsLDH can serve as a valuable biomarker for screening DKD in patients with T2D.