bluuebunny/crossref_metadata_2025_split huggingface dataset:
Semiempirical studies on the interactions of dialkyldi(aquo)tin cations, [R2Sn(H2O)2]2+, with selected nucleotides
Authors: Cassús Eduardo P. , Machado Sergio P. , Wardell James L. 
Published: February 2007

AbstractSemiempirical calculations have been carried out on the interactions of [R2Sn(H2O)2]2+, [R = H(CH2)n: n = 1–8], mainly with five nucleotides, 5′‐adenosine monophosphate (5′‐AMP), but also with guanosine 5′‐monophosphate (5′‐GMP), cytidine 5′‐monophosphate (5′‐CMP), uridine‐5′‐monophosphate (5′‐UMP) and inosine 5′‐monophosphate (5′‐IMP). The preferred sites of interaction were calculated to be the ribose O2 and O3 hydroxyl oxygens and/or the phosphate oxygens, with the nitrogen sites in the bases the least attractive to the tin compounds. This is in general agreement with experimental findings. Structures of the 1:1 coordination complexes vary from distorted tetrahedral, to distorted trigonal pyramidal to distorted octahedral geometries. Copyright © 2007 John Wiley & Sons, Ltd.
Structural studies on ruthenium(II) complexes used in interphase catalysis for the hydrogenation of ketones
Authors: Krishnan Venkata , Bertagnolli Helmut 
Published: February 2007

AbstractStructural studies were performed on catalytically active ruthenium(II) complexes used in interphases, by means of XAFS spectroscopy. The EXAFS investigations indicate that the complexes retain their structural integrity when they are embedded on polysiloxane matrices to form stationary phase materials. The AXAFS studies reveal that the variations in the catalytic activity of the complexes with different ligands can be correlated to the differences in the electronic structure around the active ruthenium center. The EXAFS investigations show that, in asymmetric transfer hydrogenation reactions catalysed by ruthenium(II) complexes, the co‐catalyst plays a crucial role not only in enhancing the catalytic activity, but also in determining the structure of the intermediate species. Copyright © 2007 John Wiley & Sons, Ltd.
Synthesis, magnetic property and DNA cleavage behavior of a new dialkoxo‐bridged diiron(III) complex
Authors: Xu Jing‐Yuan , Tian Jin‐Lei , Bian He‐Dong , Yan Shi‐Ping , Liao Dai‐Zheng , Cheng Peng , Shen Pan‐Wen 
Published: February 2007

AbstractA new dialkoxo‐bridged diiron(III) complex, [Fe2(BMA)2(CH3O)2Cl2]·2Cl·4CH3OH (1) [BMA = N,N‐bis(2‐benzimidazolylmethyl)amine], was synthesized and characterized by UV‐visible absorption and infrared spectra and magnetic susceptibilities. The complex crystallizes in the monoclinic system, space group P2(1)/n, a = 12.9659(19) Å, b = 10.0278(16) Å, c = 17.919(2) Å, β = 93.766(8)° , V = 2324.8(6) Å3, Z = 2, F(000) = 1036, Dc = 1.426 g cm−3, µ = 0.908 mm−1. According to X‐ray crystallographic studies, each Fe(III) ion lies in a highly distorted octahedral environment, and two Fe(III) ions are bridged by the methoxyl oxygens. Cryomagnetic analyses indicated a moderate antiferromagnetic interaction between the high‐spin Fe(III) ions, with J = − 27.05 cm−1. Moreover, the binding interaction of DNA with the diiron complex was investigated by spectroscopic and agarose gel electrophoretic methods, showing moderate cleavage activity on pBR322 plasmid DNA at physiological pH and temperature. Copyright © 2007 John Wiley & Sons, Ltd.
Therapeutic effect of urocortin on collagen‐induced arthritis by down‐regulation of inflammatory and Th1 responses and induction of regulatory T cells
Authors: Gonzalez‐Rey Elena , Chorny Alejo , Varela Nieves , O'Valle Francisco , Delgado Mario 
Published: February 2007

AbstractObjectiveTo investigate the potential therapeutic action of the immunomodulatory neuropeptide urocortin (UCN) in an experimental model of rheumatoid arthritis (RA).MethodsAfter disease onset, DBA/1J mice with collagen‐induced arthritis (CIA) were treated with UCN, and the incidence, severity (clinical score), and joint histopathology were evaluated. The inflammatory response was determined by measuring the levels of different mediators of inflammation (cytokines and chemokines) in the joints and sera. The Th1‐mediated autoreactive response was evaluated by determining the proliferative response and cytokine profile of draining lymph node cells stimulated with the autoantigen and by assaying the content of serum autoantibodies. The number of regulatory CD4+,CD25+ T cells and their capacity to suppress self‐reactive Th1 cells were determined in joints and lymph nodes.ResultsUCN treatment significantly reduced the incidence and severity of CIA, completely abrogating joint swelling and cartilage and bone destruction. The therapeutic effect of UCN was associated with a striking reduction of the 2 deleterious components of the disease: the Th1‐driven autoimmune response and the inflammatory response. UCN also induced the generation and/or activation of efficient interleukin‐10/transforming growth factor β1–producing Treg cells in arthritis with the capacity to suppress the autoreactive response and to restore immune tolerance, thus playing a pivotal role in the therapeutic effect of UCN.ConclusionOur findings provide a powerful rationale for assessing the efficacy of UCN as a novel multistep therapeutic approach to the treatment of RA in humans.
Electromagnetic Field Treatment of Nerve Crush Injury in a Rat Model: Effect of Signal Configuration on Functional Recovery
Authors: Walker Janet L. , Kryscio Richard , Smith Jennifer , Pilla Arthur , Sisken Betty F. 
Published: February 2007

AbstractElectromagnetic fields (EMFs) have been demonstrated to enhance mammalian peripheral nerve regeneration in vitro and in vivo. Using an EMF signal shown to enhance neurite outgrowth in vitro, we tested this field in vivo using three different amplitudes. The rat sciatic nerve was crushed. Whole body exposure was performed for 4 h/day for 5 days in a 96‐turn solenoid coil controlled by a signal generator and power amplifier. The induced electric field at the target tissue consisted of a bipolar rectangular pulse, having 1 and 0.3 ms durations in each polarity, respectively. Pulse repetition rate was 2 per second. By varying the current, the coils produced fields consisting of sham (no current) and peak magnetic fields of 0.03 mT, 0.3 mT, and 3 mT, corresponding to peak induced electric fields of 1, 10, and 100 µV/cm, respectively, at the tissue target. Walking function was assessed over 43 days using video recording and measurement of the 1–5 toe‐spread, using an imaging program. Comparing injured to uninjured hind limbs, mean responses were evaluated using a linear mixed statistical model. There was no difference found in recovery of the toe‐spread function between any EMF treatments compared to sham. Bioelectromagnetics 28:256–263, 2007. © 2007 Wiley‐Liss, Inc.
Qualified Estimation of Two Measures of Diversity Within Populations
Authors: Gillet Elizabeth M. 
Published: February 2007

AbstractEstimation of diversity within populations is a major concern in population genetics. An approach in the framework of hypothesis testing is developed, in which all hypothetical population frequencies that are not rejected on the basis of the sample frequencies define a confidence region. The test criterion requires that the sample be drawn according to a method of investigation that is qualified a priori, meaning that the probability of obtaining a sample with discrepancy not less than a given critical discrepancy from the true population frequencies not be greater than a given level of significance. Since a descriptor, such as diversity, is always a characteristic of the base population, confidence limits for the descriptor should be derived as the range of the descriptor throughout the confidence region or, by the duality between the non‐rejected hypotheses and the confidence region of a sample, as the range of the descriptor for all non‐rejected base populations. A table of minimal sample sizes for qualification is given. Geometric representations of the limits of confidence regions in 𝒮3 and 𝒮4 are shown for the absolute distance measure d0 of the discrepancy between frequency distributions. This method is applied to two measures of diversity commonly used in population genetics. Bounds on their derived confidence intervals are inferred. The computer program DIVSTAT used for calculations is introduced. (© 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Analysis of Longitudinal Count Data with Serial Correlation
Authors: Xu Stanley , Jones Richard H. , Grunwald Gary K. 
Published: February 2007

AbstractWe propose a state space model for analyzing equally or unequally spaced longitudinal count data with serial correlation. With a log link function, the mean of the Poisson response variable is a nonlinear function of the fixed and random effects. The random effects are assumed to be generated from a Gaussian first order autoregression (AR(1)). In this case, the mean of the observations has a log normal distribution. We use a combination of linear and nonlinear methods to take advantage of the Gaussian process embedded in a nonlinear function. The state space model uses a modified Kalman filter recursion to estimate the mean and variance of the AR(1) random error given the previous observations. The marginal likelihood is approximated by numerically integrating out the AR(1) random error. Simulation studies with different sets of parameters show that the state space model performs well. The model is applied to Epileptic Seizure data and Primary Care Visits Data. Missing and unequally spaced observations are handled naturally with this model. (© 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
A time‐resolved immunofluorometric assay for porcine C‐reactive protein quantification in whole blood
Authors: Martinez‐Subiela S. , Eckersall P. D. , Campbell F. M. , Parra M. D. , Fuentes P. , Ceron J. J. 
Published: February 2007

AbstractA time‐resolved immunofluorometric assay (TR–IFMA) for C‐reactive protein (CRP) determination in whole blood of pigs was developed and validated. CRP was isolated from porcine acute‐phase serum by affinity chromatography on agarose, coupled with phosphorylethanolamine and polyclonal antibodies to porcine CRP were purified from antiserum raised in sheep immunized with porcine CRP. Intra‐ and inter‐assay coefficients of variation (CVs) were in the range 3.13–7.19% and 7.06–15.66%, respectively, showing good precision. The assay measured the CRP values in a proportional and linear manner (r= 0.99); additionally, CRP concentrations measured in whole blood by the present TR–IFMA and in serum by an established immunoturbidimetric assay were highly correlated (R2= 0.97). The limit of detection of the method was 0.0028 mg/L. Significantly lower CRP concentrations were observed after 7 days of sample storage at 4°C. The injection of turpentine oil caused a significant increase in CRP concentrations and significantly higher CRP concentrations were observed in pigs with pathological processes compared to healthy animals. Copyright © 2007 John Wiley & Sons, Ltd.
Optimizing the tuning parameters of least squares support vector machines regression for NIR spectra
Authors: Coen T. , Saeys W. , Ramon H. , De Baerdemaeker J. 
Published: February 2007

AbstractPartial least squares (PLS) is one of the most used tools in chemometrics. Other data analysis techniques such as artificial neural networks and least squares support vector machines (LS‐SVMs) have however made their entry in the field of chemometrics. These techniques can also model nonlinear relations, but the presence of tuning parameters is a serious drawback. These parameters balance the risk of overfitting with the possibility to model the underlying nonlinear relation. In this work a methodology is proposed to initialize and optimize those tuning parameters for LS‐SVMs with radial basis function (RBF)‐kernel based on a statistical interpretation. In this way, these methods become much more appealing for new users. The presented methods are applied on manure spectra. Although this dataset is only slightly nonlinear, good results were obtained. Copyright © 2007 John Wiley & Sons, Ltd.
Sb2Hg3GaBr4: A New Supramolecular Framework Structure with [Sb2Hg4/2].+‐.0 Building Blocks Isosteric to Distibane.
Authors: Schlirf J. , Deiseroth H. J. 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Chemical Vapor Transport and Crystal Structure of Rare‐Earth Antimonates(V) — LnSbO4.
Authors: Gerlach Sylvia , Cardoso‐Gil Raul , Milke Edgar , Schmidt Marcus 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
The Use of Vinyl Sulfonium Salts in the Stereocontrolled Asymmetric Synthesis of Epoxide‐ and Aziridine‐Fused Heterocycles: Application to the Synthesis of (‐)‐Balanol.
Authors: Unthank Matthew G. , Hussain Nigel , Aggarwal Varinder K. 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
CeCl3×7H2O: An Efficient and Reusable Catalyst for the Preparation of β‐Acetamido Carbonyl Compounds by Multi‐Component Reactions (MCRs).
Authors: Khan Abu T. , Choudhury Lokman H. , Parvin Tasneem , Ali Md. Asif 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Catalytic Thiocyanation of Aryldiazonium Salts in the Presence of Copper Salts.
Authors: Beletskaya Irina P. , Sigeev Alexander S. , Peregudov Alexander S. , Petrovskii Pavel V. 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Reactivity of Diarylmethane Derivatives in Supercritical Alcohols Media: Reduction of Diarylmethanols and Diaryl Ketones to Diarylmethanes Using Supercritical 2‐Propanol.
Authors: Hatano Bunpei , Kubo Daisuke , Tagaya Hideyuki 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Convenient “One‐Pot” Synthesis of 3,4‐Substituted Tetrahydrothiophenes Through Tandem Michael—Henry and Michael—Michael Reactions.
Authors: Barco Achille , Baricordi Nikla , Benetti Simonetta , De Risi Carmela , Pollini Gian Piero 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
New Practical Synthesis of Indazoles via Condensation of o‐Fluorobenzaldehydes and Their O‐Methyloximes with Hydrazine.
Authors: Lukin Kirill , Hsu Margaret C. , Fernando Dilinie , Leanna M. Robert 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Using Ionic Liquid [EMIM][CH3COO] as an Enzyme‐“Friendly” Co‐Solvent for Resolution of Amino Acids.
Authors: Zhao Hua , Jackson Lee , Song Zhiyan , Olubajo Olarongbe 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Studies on the Total Synthesis of Lactonamycin (VI): Synthesis of the CDEF Ring System (V).
Authors: Wehlan Hermut , Jezek Eva , Lebrasseur Nathalie , Pave Gregoire , Roulland Emmanuel , White Andrew J. P. , Burrows Jeremy N. , Barrett Anthony G. M. 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Prediction of Multiple Binding Modes of the CDK2 Inhibitors, Anilinopyrazoles, Using the Automated Docking Programs GOLD, FlexX, and LigandFit: An Evaluation of Performance.
Authors: Sato Hideyuki , Shewchuk Lisa M. , Tang Jun 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Size‐Controllable Fabrication of Noble Metal Nanonets Using a TiO2 Template.
Authors: Yang Lixia , Cai Qingyun , Yu Yan 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Implantable cardioverter defibrillators for prevention of sudden cardiac Death
Authors: Sukhija Rishi , Mehta Vimal , Leonardi Marino , Mehta Jawahar L. 
Published: February 2007

AbstractDespite the multiple advances in the field of cardiovascular medicine, the incidence of sudden cardiac death (SCD) continues to rise. Of all SCDs, <25% occur in individuals deemed at high risk by current risk‐stratification algorithms; hence, these risk‐stratification algorithms are not satisfactory. Until better markers are identified to risk stratify patients, we will see an increasing use of implantable cardioverter defibrillators (ICDs). However, even with the increase in defibrillator use, the impact on overall incidence of SCD may only be modest, as many individuals experience SCD as the first manifestation of cardiovascular disease. Another important challenge is widespread availability of automated external defibrillators and effective utilization of public access defibrillation programs for timely and appropriate management of out‐of‐hospital victims with cardiac arrest. This review discusses the current understanding on SCD, risk stratification, and management aimed at reducing SCD, particularly with the use of ICDs. Copyright © 2007 John Wiley & Sons, Ltd.
Features of the metabolic syndrome and prostate cancer in African‐American men
Authors: Beebe‐Dimmer Jennifer L. , Dunn Rodney L. , Sarma Aruna V. , Montie James E. , Cooney Kathleen A. 
Published: February 2007

AbstractBACKGROUND.Metabolic syndrome refers to a cluster of conditions that includes hypertension, dyslipidemia, central adiposity, and high blood glucose levels. Over the past decade, a growing body of literature suggests that metabolic syndrome may be associated with several different forms of cancer. Because prostate cancer risk is highest among African Americans, and these men, similarly, are more prone to developing specific features of the metabolic syndrome, including hypertension and type‐2 diabetes, any relationships would have a significant impact on developing strategies for the primary prevention of prostate cancer.METHODS.The Flint Men's Health Study is a community‐based, case‐control study of prostate cancer conducted exclusively among African Americans. Prostate cancer cases and controls completed an interviewer‐administered questionnaire that asked about the respondent's history of high blood pressure and diabetes. All men also participated in a physical examination in which several measures of body composition, including waist circumference, were collected.RESULTS.Hypertension was reported more commonly among men with prostate cancer (cases) compared with men in the control group (odds ratio [OR]. 2.4; 95% confidence interval [95% CI], 1.5–3.7), and cases were more likely to have a waist circumference >102 cm (OR, 1.8; 95% CI, 1.2–2.9). However, self‐reported diabetes was not associated with prostate cancer risk. The men with prostate cancer also were more likely than controls to exhibit multiple syndrome characteristics (OR, 1.9; 95% CI, 1.2–3.0).CONCLUSIONS.The current results indicated that features of the metabolic syndrome, specifically abdominal obesity and hypertension, are associated with prostate cancer in African‐American men. This relationship, if it is proved causal, suggests that prevention or control of these conditions eventually may lead to a reduction in the incidence of prostate cancer in this high‐risk minority group. Cancer 2007 © 2007 American Cancer Society.
Ten‐year results of a prospective study on the prognostic role of ploidy in endometrial carcinoma
Authors: Susini Tommaso , Amunni Gianni , Molino Cecilia , Carriero Carlo , Rapi Stefano , Branconi Francesco , Marchionni Mauro , Taddei Gianluigi , Scarselli Gianfranco 
Published: February 2007

AbstractBACKGROUND.To improve the outcome of endometrial cancer patients, a more accurate prognostic assessment is mandatory. The aims of the study were to evaluate the role of flow cytometric DNA ploidy as an independent prognostic factor in patients with endometrial cancer and to verify if ploidy was able to distinguish patients with different prognosis into homogeneous subgroups for grade of differentiation and stage.METHODS.In a prospective study, DNA ploidy was evaluated from fresh tumor samples in 174 endometrial cancer patients who underwent surgery as the first treatment. Ploidy, as well as classical parameters, were analyzed in relation to the length of disease‐free survival and disease‐specific survival.RESULTS.DNA aneuploidy was found in 49 patients (28.2%). Patients with DNA‐aneuploid tumors had a significantly reduced disease‐free interval and disease‐specific survival (P < .0001). The 10‐year survival probability was 53.2% for DNA‐aneuploid patients and 91.0% for patients with DNA‐diploid tumors. By multivariate analysis DNA‐aneuploid type was the strongest independent predictor of poor outcome, followed by age and stage. Patients with DNA‐aneuploid tumor had a significantly higher risk ratio for recurrence (5.03) and death due to disease (6.50) than patients with DNA‐diploid tumors. Stratification by DNA‐ploidy within each group by grade of differentiation allowed identification of patients with significantly different outcome. In grade 2 tumors, 10‐year survival was 45.0% in aneuploid cases and 91.9% in diploid cases (P < .0001). Patients with advanced‐stage (>I) diploid tumor did significantly better than patients with stage I aneuploid tumor (P = .04).CONCLUSIONS.The presence of DNA‐aneuploid type in endometrial cancer identifies high‐risk cases among the patients considered ‘low risk’ according to stage and grade of differentiation. Cancer 2007. © 2007 American Cancer Society.