bluuebunny/crossref_metadata_2025_split huggingface dataset:
Plant‐sediment interactions decouple inorganic from organic carbon stock development in salt marsh soils
Authors: Granse Dirk , Wanner Antonia , Stock Martin , Jensen Kai , Mueller Peter 
Published: March 2024

AbstractThe storage of organic carbon in the soils of salt marshes and other coastal blue carbon ecosystems has gained considerable attention by the scientific community for more than a decade now, while the relevance and mechanisms of soil inorganic carbon accumulation remain poorly understood. Using long‐term annual accretion monitoring over 17 years in N = 50 permanent plots distributed across a 1050‐ha salt‐marsh complex of the European Wadden Sea, we identified clear relationships between salt‐marsh vertical growth rates and the soil densities of inorganic and organic carbon. Specifically, we demonstrate a strong positive correlation between vertical accretion and inorganic carbon density while observing a strong negative correlation between vertical accretion and organic carbon density. This decoupling observed between inorganic and organic soil carbon stocks was governed by plant community composition and associated plant traits, which controlled sedimentation processes.
A Transparent and Injectable Biomaterial Prepared by Mixing Collagen and Anti‐Cancer Platinum Derivatives
Authors: Ichise Shinichiro F. , Koide Takaki 
Published: March 2024

AbstractThis study presents the synthesis of a cross‐linked collagen material, named platinum‐containing collagen gel (PCG), which is achieved by simply mixing collagen and derivatives of an anti‐cancer platinum complex. The cross‐linking reagents are derivatives of cisplatin or transplatin, generated through a ligand exchange with dimethyl sulfoxide. PCG exhibits superior physical strength and transparency compared with the native collagen gel formed through spontaneous fibril formation. The versatility of PCG as a cell culture scaffold, applicable to both 2D and 3D models, with low cytotoxicity is demonstrated. Furthermore, PCG exhibits pH‐responsive gel‐forming properties. This enables the removal of free cross‐linker by dialysis in an acidic solution and subsequent gel formation upon neutralization. This material holds promise for application in cell culture scaffolds and medical injections.
4D Fabrication of Two‐Way Shape Memory Polymeric Composites by Electrospinning and Melt Electrowriting
Authors: Pasini Chiara , Soreño Zhander Vohr , Schönfeld Dennis , Pretsch Thorsten , Constante Gissela , Sadilov Ilia , Ionov Leonid 
Published: March 2024

AbstractThis work presents a new method for 4D fabrication of two‐way shape memory materials that are capable of reversible shapeshifting right after manufacturing, upon application of proper heating and cooling cycles. The innovative solution presented here consists in the combination of highly stretched electrospun shape memory polymer (SMP) nanofibers with a melt electrowritten elastomer. More specifically, the stretched nanofibers are made of a biocompatible thermoplastic polyurethane (TPU) with crystallizable soft segments, undergoing melt‐induced contraction and crystallization‐induced elongation upon heating and cooling, respectively. Reversible actuation during crystallization becomes possible due to the elastic recovery of the elastomer component, obtained by melt electrowriting of a commercial TPU filament. Thanks to the design freedom offered by additive manufacturing, the elastomer structure also has the role of guiding the shape transformation. Electrospinning and melt electrowriting process parameters are set up so to obtain smart 4D objects capable of two‐way shape memory effect (SME), and the possibility of reversible and repeatable actuation is demonstrated. The two components are then combined in different proportions with the aim of tailoring the two‐way SME, taking into account the effect of design parameters such as the SMP content, the elastomer pattern, and the composite thickness.
Genome‐scale CRISPR–Cas9 screen identifies PAICS as a therapeutic target for EGFR wild‐type non‐small cell lung cancer
Authors: Li Yufeng , Zhu Lingyun , Mao Jiaqi , Zheng Hongrui , Hu Ziyi , Yang Suisui , Mao Tianyu , Zhou Tingting , Cao Pingping , Wu Hongshuai , Wang Xuerong , Wang Jing , Lin Fan , Shen Hua 
Published: March 2024

AbstractEpidermal growth factor receptor‐targeted (EGFR‐targeted) therapies show promise for non‐small cell lung cancer (NSCLC), but they are ineffective in a third of patients who lack EGFR mutations. This underlines the need for personalized treatments for patients with EGFR wild‐type NSCLC. A genome‐wide CRISPR/Cas9 screen has identified the enzyme phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS), which is vital in de novo purine biosynthesis and tumor development, as a potential drug target for EGFR wild‐type NSCLC. We have further confirmed that PAICS expression is significantly increased in NSCLC tissues and correlates with poor patient prognosis. Knockdown of PAICS resulted in a marked reduction in both in vitro and in vivo proliferation of EGFR wild‐type NSCLC cells. Additionally, PAICS silencing led to cell‐cycle arrest in these cells, with genes involved in the cell cycle pathway being differentially expressed. Consistently, an increase in cell proliferation ability and colony number was observed in cells with upregulated PAICS in EGFR wild‐type NSCLC. PAICS silencing also caused DNA damage and cell‐cycle arrest by interacting with DNA repair genes. Moreover, decreased IMPDH2 activity and activated PI3K–AKT signaling were observed in NSCLC cells with EGFR mutations, which may compromise the effectiveness of PAICS knockdown. Therefore, PAICS plays an oncogenic role in EGFR wild‐type NSCLC and represents a potential therapeutic target for this disease.
Maresin‐1 ameliorates hypertensive vascular remodeling through its receptor LGR6
Authors: Yin Zheng , Zhang Jishou , Zhao Mengmeng , Peng Shanshan , Ye Jing , Liu Jianfang , Xu Yao , Xu Shuwan , Pan Wei , Wei Cheng , Qin Juan‐Juan , Wan Jun , Wang Menglong 
Published: March 2024

AbstractHypertensive vascular remodeling is defined as the changes in vascular function and structure induced by persistent hypertension. Maresin‐1 (MaR1), one of metabolites from Omega‐3 fatty acids, has been reported to promote inflammation resolution in several inflammatory diseases. This study aims to investigate the effect of MaR1 on hypertensive vascular remodeling. Here, we found serum MaR1 levels were reduced in hypertensive patients and was negatively correlated with systolic blood pressure (SBP). The treatment of MaR1 reduced the elevation of blood pressure and alleviated vascular remodeling in the angiotensin II (AngII)‐infused mouse model. In addition, MaR1‐treated vascular smooth muscle cells (VSMCs) exhibited reduced excessive proliferation, migration, and phenotype switching, as well as impaired pyroptosis. However, the knockout of the receptor of MaR1, leucine‐rich repeat‐containing G protein‐coupled receptor 6 (LGR6), was seen to aggravate pathological vascular remodeling, which could not be reversed by additional MaR1 treatment. The mechanisms by which MaR1 regulates vascular remodeling through LGR6 involves the Ca2+/calmodulin‐dependent protein kinase II/nuclear factor erythroid 2‐related factor 2/heme oxygenase‐1 signaling pathway. Overall, supplementing MaR1 may be a novel therapeutic strategy for the prevention and treatment of hypertension.
Accumulation of TOX high mobility group box family member 3 promotes the oncogenesis and development of hepatocellular carcinoma through the MAPK signaling pathway
Authors: Peng Yufu , Yu Jing , Liu Fei , Tang Leyi , Li Bo , Zhang Wei , Chen Kefei , Zhang Haili , Wei Yonggang , Ma Xuelei , Shi Hubing 
Published: March 2024

AbstractMicrovascular invasion (MVI) has been widely valued in the field of liver surgery because MVI positivity indicates poor prognosis in hepatocellular carcinoma (HCC) patients. However, the potential molecular mechanism underlying the poor prognosis of MVI‐positive HCC patients is unclear. Therefore, this study focused on identifying the key genes leading to poor prognosis in patients with a high degree of malignancy of HCC by examining the molecular signaling pathways in MVI‐positive HCC patients. Through RNA sequencing, TOX high mobility group box family member 3 (TOX3) was demonstrated to be significantly highly expressed in MVI‐positive HCC tissues, which was associated with poor prognosis. The results of in vivo and in vitro showed that TOX3 can promote the oncogenesis and development of HCC by targeting key molecules of the MAPK and EMT signaling pathways. The IP‐MS results indicated that proteasome degradation of TOX3 in HCC cells is potentially mediated by a tripartite motif containing 56 (TRIM56, an E3 ligase) in HCC cells. Inhibiting TRIM56 enhances TOX3 protein levels. Overall, our study identified TOX3 as a key gene in the MAPK and EMT signaling pathways in HCC, and its overexpression confers significant proliferation and invasiveness to tumor cells.
Coffee and caffeine consumption and risk of periodontitis: National Health and Nutrition Examination Survey 2009–2014
Authors: Liao Wan‐Zhe , Zhou Zhi‐Yi , Wu Xian‐Nan , Zhu Xiao‐Feng , Li Song‐An , Zheng Jun‐Huang , Tan Jia‐Nuo , Chen Hao‐Kai , Gu Ting‐Yu , Xu Zhe , Li Ya‐Han , Guo Xu‐Guang 
Published: March 2024

AbstractBackgroundThis study aimed to evaluate whether coffee consumption and caffeine intake are independently associated with periodontitis infection.MethodsCoffee consumption was categorized into binary and continuous variables, serving as the exposure factor alongside caffeine intake, with periodontitis infection as the outcome variable. Other covariables were regarded as potential confounders. The cross‐sectional study was conducted based on the national health and nutrition examination survey, with multivariate regression models, subgroup analyses, smooth fitting curves, and threshold effect examinations conducted to pursue a definite correlation between exposures and the outcome.ResultsNegative associations were discovered between binary coffee consumption (OR = 0.81, 95% CI = (0.71, 0.92), p‐value = 0.001) and caffeine intake (Q3: OR = 0.77, 95% CI = (0.66, 0.91), p‐value = 0.002; Q4: OR = 0.76, 95% CI = (0.64, 0.90), p‐value = 0.001) with periodontitis infection, respectively, with all confounders adjusted. In subgroup analyses stratified by gender, diabetes mellitus status, and hypertension status, interaction, and threshold effects were observed, which were intuitively revealed by smooth‐fitting curves.ConclusionsSignificant negative associations between binary consumption and caffeine intake and periodontitis infection separately were indicated, with no evidence suggesting a credible correlation between continuous coffee consumption and infection risk of periodontitis. The benefits of the behavior of consuming coffee and caffeine were more obvious among males and individuals who did not suffer from diabetes or hypertension.
Self‐equalized linear‐phase microstrip bandpass filter based on negative group delay parallel‐coupled three‐line units
Authors: Zhang Awei , Xu Jinping , Zhiqiang Liu 
Published: March 2024

AbstractA self‐equalized linear‐phase microstrip bandpass filter (BPF) utilizing negative group delay (NGD) parallel‐coupled three‐line (PCTL) units is presented in this letter. The NGD PCTL unit possesses an NGD valley in its frequency response of group delay (GD). By a combination of two or more NGD valleys, the sharp positive GD peaks at passband edges of a conventional coupled‐line BPF are counterbalanced, resulting in a linear phase response over the entire passband. A prototype of linear‐phase BPF in S‐band is designed by replacing two coupled‐line units in a three‐pole conventional BPF with the proposed NGD PCTL units. Measured passband GD fluctuation of the BPF utilizing NGD PCTL units is 0.5 ns while that of the BPF using conventional coupled‐line units is 1.7 ns, a considerable improvement of 70.5% is achieved with no increase in overall time delay. The out‐of‐band suppression is well retained, and the circuit size is 0.18 λg2.
Investigating the psychometric properties of PaRCADS—Parenting to Reduce Child Anxiety and Depression Scale in a Norwegian sample
Authors: Ytreland Kristin , Ingul Jo Magne , Lydersen Stian , Yap Marie Bee Hui , Sim Wan Hua , Sund Anne Mari , Bania Elisabeth Valmyr 
Published: March 2024

AbstractObjectivesParents play a pivotal role in child development and several parental factors have been identified as risk or protective factors for childhood anxiety and depression. To assess and target these parental factors in interventions, there is a need for a comprehensive, easy‐to‐use instrument.MethodThis study aimed to investigate the psychometric properties of an adapted version of the Parenting to Reduce Child Anxiety and Depression Scale, PaRCADS(N) in a Norwegian community sample (N = 163) of parents of children aged 8–12 years.ResultsOur findings indicate that PaRCADS(N) has acceptable psychometric properties. These results are comparable to those of the original study of the PaRCADS in Australia.ConclusionBased on these results, we recommend that PaRCADS(N) can be utilized by health care workers as a tool for assessment and identification of parental practices related to child anxiety and/or depression to target relevant risk and protective factors in treatment and prevention.
Dispersion Polymerization of N‐Vinyl‐2‐Pyrrolidone in Supercritical Carbon Dioxide in the Presence of Thiol‐Terminated Poly(vinyl acetate‐co‐vinyl propionate)
Authors: Zhang Shoucun , Wang Shengyan , Wu Wenli , Wu Jinlong , Du Jianghua 
Published: March 2024

AbstractLiquid carbon dioxide (LCO2) or supercritical carbon dioxide (ScCO2) can be used as an important solvent medium for preparing polymer particles through dispersion polymerization. However, based on the weak solvent characteristics of CO2, the development of stabilizers used in dispersion polymerization has always been an important challenge. These stabilizers are progressing toward the low‐cost, pollution‐free, and simple synthesis routes, et al. In this research, pentaerythritol tetra (3‐mercaptopropionate) (PTMP) is used to control the homopolymerization or copolymerization of vinyl acetate (VAc)/vinyl propionate (VPr), the homopolymers or copolymers with thiol group are synthesized by the one‐pot method. These homopolymers or copolymers are used as the stabilizers to stabilize the dispersion polymerization of N‐vinyl‐2‐pyrrolidone (NVP) in ScCO2. The results show that the structural unit proportion of the stabilizers, the concentration of stabilizers or 2, 2´‐azobis(isobutyronitrile) (AIBN), and the time interval for dispersion polymerization have significant impacts on the conversion percentage of NVP and the molecular weight of polymers. The maximum conversion percentage of NVP can get to 95%, and the molecular weight of poly(N‐vinyl‐2‐pyrrolidone)(PNVP) can reach 22.3 kPa. SEM analysis indicates that the PNVP obtained has regular spherical characteristics.
Reference values for nerve conduction studies of the peroneal, tibial, and sural nerve derived from a large population‐based cohort: Associations with demographic and anthropometric characteristics—The Maastricht study
Authors: Hodzelmans Jurriaan J. A. , Janssen Marcus L. F. , Reulen Jos P. H. , Blijham Paul J. , Koster Annemarie , Stehouwer Coen D. A. , Mess Werner H. , Sutedja Nadia A. 
Published: March 2024

AbstractIntroduction/AimsNerve conduction studies (NCSs) are widely used to support the clinical diagnosis of neuromuscular disorders. The aims of this study were to obtain reference values for peroneal, tibial, and sural NCSs and to examine the associations with demographic and anthropometric factors.MethodsIn 5099 participants (aged 40–79 years) without type 2 diabetes of The Maastricht Study, NCSs of peroneal, tibial, and sural nerves were performed. Values for compound muscle action potential (CMAP) and sensory nerve action potential amplitude, nerve conduction velocity (NCV), and distal latency were acquired. The association of age, sex, body mass index (BMI), and height with NCS values was determined using uni‐ and multivariate linear regression analyses.ResultsDetailed reference values are reported per decade for men and women. Significantly lower NCVs and longer distal latencies were observed in all nerves in older and taller individuals as well as in men. In these groups, amplitudes of the tibial and sural nerves were significantly lower, whereas a lower peroneal nerve CMAP was only significantly associated with age. BMI showed a multidirectional association. After correction for anthropometric factors in the multivariate analysis, the association between sex and NCS values was less straightforward.DiscussionThese values from a population‐based dataset could be used as a reference for generating normative values. Our findings show the association of NCS values with anthropometric factors. In clinical practice, these factors can be considered when interpreting NCS values.
Total positivity and least squares problems in the Lagrange basis
Authors: Marco Ana , Martínez José‐Javier , Viaña Raquel 
Published: March 2024

SummaryThe problem of polynomial least squares fitting in the standard Lagrange basis is addressed in this work. Although the matrices involved in the corresponding overdetermined linear systems are not totally positive, rectangular totally positive Lagrange‐Vandermonde matrices are used to take advantage of total positivity in the construction of accurate algorithms to solve the considered problem. In particular, a fast and accurate algorithm to compute the bidiagonal decomposition of such rectangular totally positive matrices is crucial to solve the problem. This algorithm also allows the accurate computation of the Moore‐Penrose inverse and the projection matrix of the collocation matrices involved in these problems. Numerical experiments showing the good behaviour of the proposed algorithms are included.
Effect of cover crops on soil health at different landscape positions
Authors: Oliveira da Silva Franciny 
Published: March 2024

AbstractSoil health is crucial to reaching high yields, and growing cover crops can help improve soil conditions. The goal of this study is to determine the effects of cover crops on soil health using potential respiration, potential nitrogen mineralization, and aggregates stability as indicators of soil health. The study has been conducted since 2019 at the University of Kentucky Spindletop Farm, Lexington, KY, and involves three landscape positions receiving a treatment with cereal rye, cereal rye–crimson clover mixture, and fallow soil. This study emphasized that cover crops can enhance potential respiration and microbial activity over landscape positions, with rye being more beneficial than the mixture treatment. However, cover crops were also beneficial for aggregate stability but not for potential nitrogen mineralization.
A cattle mandible thong‐smoother from a grave: Strap production and cattle traction in the Late Copper Age in Hungary
Authors: Gál Erika , Rácz Piroska , Bondár Mária 
Published: March 2024

AbstractA recently found cattle‐based mandibular thong‐smoother, which was the only bone tool in the Baden culture burial of a 6–10‐year‐old child at the site of Balatonlelle‐Rádpuszta‐Romtemplom mellett (western Hungary), represents the best‐preserved Eneolithic implement in this category ever published in Hungary. Being one of the oldest specimens from the distribution area of mandibular thong‐smoothers, it brings new information regarding the origin and possible use of this rarely identified type of tool linked to strap and thong‐making in the period from the Eneolithic to the Middle Bronze Age. Having been recovered from the grave of a child, it draws attention to the possibility that children may have been involved in strap production. The evaluation of analogies from and outside of Hungary also offered a complex review of mandibular thong‐smoothers. In addition to the role of these implements in taming and driving horses already discussed in the specialist literature, we also point to their involvement in the use of harnessed cattle for draught and transport, and its linkage to the spread of wagon and carriage in the wake of the 4th millennium.
The impact of a preoperative evaluation process on weight reduction and glycemic control in patients undergoing bariatric and metabolic surgery
Authors: Tempany Jennifer , Collier Andrew , Ali Abdulmajid 
Published: March 2024

AbstractIntroductionMetabolic surgery is a sustainable intervention for obesity and type 2 diabetes. Preoperative education optimizes weight loss and glycemic control outcomes.ObjectiveThis study aimed to determine the effect of a generalized preoperative evaluation process (PEP) in patients who underwent bariatric surgery on weight loss and glycemic control pre‐ and post‐surgery.MethodsData were retrospectively collected and analyzed for patients with type 2 diabetes who underwent bariatric surgery between 2010 and 2016. Patients were categorized into two groups determined by participation in the PEP. The groups were named the PEP group and non‐PEP group. The correlation among engagement in the PEP was determined using the chi‐square test and t‐test. Statistical analysis with p < 0.05 was deemed significant.Results129 patients were included in the study; 86 females (67%) and 43 males (33%). Fifty‐nine patients (46%) engaged in the PEP and 70 (54%) patients did not engage in the PEP. A greater reduction in weight loss was observed in the PEP group versus the non‐PEP group from initial enrollment to pre‐surgery (14.3 ± 9.2 kg vs. 11.6 ± 9.2 kg; p = 0.11), and from pre‐surgery to 2‐years post‐surgery (20.6 ± 14.8 kg vs. 16.9 ± 15.6 kg; p = 0.17). A greater reduction in HbA1c from initial enrollment to pre‐surgery was seen in the PEP group versus the non‐PEP group (0.90 ± 1.28% vs. 0.63 ± 1.07%); however, this was not maintained from pre‐surgery to 2‐year post‐surgery (0.51 ± 1.18% vs. 0.70 ± 1.73%). In both cases, the statistical difference was insignificant.ConclusionThe PEP was not associated with improvements in short‐term weight loss or glycemic control pre‐surgery and a 2‐years post‐surgery. Patients may benefit from individually tailored preoperative weight management strategies.