bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spatial Architecture of Myeloid and T Cells Orchestrates Immune Evasion and Clinical Outcome in Lung Cancer
Authors: Enfield Katey S.S. , Colliver Emma , Lee Claudia , Magness Alastair , Moore David A. , Sivakumar Monica , Grigoriadis Kristiana , Pich Oriol , Karasaki Takahiro , Hobson Philip S. , Levi Dina , Veeriah Selvaraju , Puttick Clare , Nye Emma L. , Green Mary , Dijkstra Krijn K. , Shimato Masako , Akarca Ayse U. , Marafioti Teresa , Salgado Roberto , Hackshaw Allan ,   TRACERx consortium, Jamal-Hanjani Mariam , van Maldegem Febe , McGranahan Nicholas , Glass Benjamin , Pulaski Hanna , Walk Eric , Reading James L. , Quezada Sergio A. , Hiley Crispin T. , Downward Julian , Sahai Erik , Swanton Charles , Angelova Mihaela 
Published: April 2024

Abstract

Understanding the role of the tumor microenvironment (TME) in lung cancer is critical to improving patient outcomes. We identified four histology-independent archetype TMEs in treatment-naïve early-stage lung cancer using imaging mass cytometry in the TRACERx study (n = 81 patients/198 samples/2.3 million cells). In immune-hot adenocarcinomas, spatial niches of T cells and macrophages increased with clonal neoantigen burden, whereas such an increase was observed for niches of plasma and B cells in immune-excluded squamous cell carcinomas (LUSC). Immune-low TMEs were associated with fibroblast barriers to immune infiltration. The fourth archetype, characterized by sparse lymphocytes and high tumor-associated neutrophil (TAN) infiltration, had tumor cells spatially separated from vasculature and exhibited low spatial intratumor heterogeneity. TAN-high LUSC had frequent PIK3CA mutations. TAN-high tumors harbored recently expanded and metastasis-seeding subclones and had a shorter disease-free survival independent of stage. These findings delineate genomic, immune, and physical barriers to immune surveillance and implicate neutrophil-rich TMEs in metastasis.

Significance:
This study provides novel insights into the spatial organization of the lung cancer TME in the context of tumor immunogenicity, tumor heterogeneity, and cancer evolution. Pairing the tumor evolutionary history with the spatially resolved TME suggests mechanistic hypotheses for tumor progression and metastasis with implications for patient outcome and treatment.
This article is featured in Selected Articles from This Issue, p. 897
A Molecular Voyage: Multiomics Insights into Circulating Tumor Cells
Authors: Zhang Yu Wei , Gvozdenovic Ana , Aceto Nicola 
Published: April 2024

Abstract

Circulating tumor cells (CTCs) play a pivotal role in metastasis, the leading cause of cancer-associated death. Recent improvements of CTC isolation tools, coupled with a steady development of multiomics technologies at single-cell resolution, have enabled an extensive exploration of CTC biology, unlocking insights into their molecular profiles. A detailed molecular portrait requires CTC interrogation across various levels encompassing genomic, epigenetic, transcriptomic, proteomic and metabolic features. Here, we review how state-of-the-art multiomics applied to CTCs are shedding light on how cancer spreads. Further, we highlight the potential implications of CTC profiling for clinical applications aimed at enhancing cancer diagnosis and treatment.

Significance:
Exploring the complexity of cancer progression through cutting-edge multiomics studies holds the promise of uncovering novel aspects of cancer biology and identifying therapeutic vulnerabilities to suppress metastasis.
Indigeneity at the 1948 Bogotá Conference
Authors: Lixinski Lucas 
Published: April 2024

Abstract
The article examines the history and legacy of the Bogotá diplomatic conference of 1948 in relation to Indigenous peoples. Indigenous voices were entirely absent from the Bogotá conference itself, and delegates relied instead on certain assumptions and narratives largely drawn from the Indigenismo movement in the Americas at the time. In considering Indigenous peoples as part of a broader social agenda, delegates confronted the legacies of colonialism and the ongoing exploitation and resistance of Indigenous peoples, invoking threads that we today might label a racial capitalism critique of international law. Their efforts, however salutary, culminated in an instrument, the Inter-American Charter of Social Guarantees, that was never ultimately adopted. Nevertheless, the debates at Bogotá are illuminating of the subsequent trajectory of Indigenous peoples’ rights in international law, and the alternative possibilities that can still be recovered to live up to the Bogotá conference delegates’ aspirations of Indigenous emancipation.
The Blood Brotherhood and Colonial Treaties and Alliances: Between Myth and Reality
Authors: Van Hulle Inge 
Published: April 2024

Abstract
This article examines the representation and use of the blood exchange between European expeditionary leaders, that worked in the service of king Leopold II, and African rulers in Central and East Africa during the late nineteenth century. While the blood brotherhood played a role in the appeasement of African rulers and the conclusion of treaties, the details and origins of the procedure are often unclear. Europeans believed that the blood brotherhood was an African legal custom, even though recent anthropological studies suggest it differed from the inter-African version of the blood brotherhood. Europeans styled the blood brotherhood as the African counterpart to the European treaty, which served to support the legality of the much-contested treaties that Leopold II’s representatives had concluded, often under dubious circumstances. While the blood brotherhood therefore functioned as a practical tool to establish European influence and sovereignty over African rulers, it was also as a means of glorifying the white European explorer as a pseudo-scientist and well-meaning broker of peace. This article complicates the traditional narrative of how treaties were concluded during the Scramble for Africa and highlights the need for a critical re-examination of the legal practices and representations of colonialism.
Locating the 1948 Economic Agreement of Bogotá: The Rise and Fall of Latin America’s International Economic Law Project
Authors: Perrone Nicolás M. 
Published: April 2024

Abstract
This article claims that Latin America developed a competing International Economic Law project in the 1940s. These ideas and practices served the region to imagine its economic development process. Through the work of economists and lawyers – especially international lawyers – Latin America envisioned a future of industrialization and designed a strategy to make it happen. In the 1940s, many Latin Americans were enthusiastic about the prospects of industrialization; however, the consensus was that this objective required regional cooperation to reshape international trade and foreign investment laws among themselves and, especially, vis-à-vis the United States. This article explores this regional momentum focusing on the 1948 Economic Agreement of Bogotá, one of the most important international economic law-making efforts in the Western Hemisphere. In Bogotá, many Latin American governments insisted that states, not markets or foreign investors, should plan the region’s economic future. The United States and the US business elite disagreed.
The (Latin) American Dream? Human Rights and the Construction of Inter-American Regional Organisation (1945–1948)
Authors: Quintana Francisco-José 
Published: April 2024

Abstract
The American Declaration of the Rights and Duties of Man is often cited as evidence of the longstanding centrality of human rights in Latin American approaches to international law. However, when the Declaration is brought into the history of inter-American regionalism, a more complex picture emerges. This article places the early codification efforts of regional human rights within the post-war construction of inter-American regional organisation. It argues that for Latin American and US elites, the priorities lay on institutional, collective security, and economic aspects. In this context, they instrumentally embraced the flexible language of human rights to advance broader regionalist visions. As a result, human rights gained ground, albeit as a contested idea. The article reveals that the post-war institutional settlement ultimately comprised a collective security apparatus, crucial for the United States, supplemented by the principle of non-intervention, vital to Latin American states, in which human rights were not central.
Organizing Peace in the Americas: Collective Security versus International Adjudication
Authors: Uriburu Justina 
Published: April 2024

Abstract
American states concluded two treaties to organize peace in the postwar world: the Rio Treaty (1947) and the Pact of Bogotá (1948). At first sight, they appear to reflect a division of tasks: the Rio Treaty would address threats to the peace and security of the Americas, and the Pact of Bogotá would help solve the disputes between American states. However, the Rio Treaty’s dominance during the Cold War calls this division into question. This paper first argues that American states pursued two projects of peace. The Rio Treaty was a defence pact with an autonomous enforcement mechanism, to which the United States was strongly committed. The Pact of Bogotá reflected Latin American states’ thinking that a comprehensive framework for solving disputes would mitigate regional power asymmetries. Second, it claims that the Rio Treaty’s vague provisions and the US support it enjoyed facilitated its dominance during the Cold War.
The 2020 Revision of the Algerian Constitution and the Ḥirāk: Returning to Constitutional Order after the Institutional Disorders of 2019
Authors: Cherbi Massensen 
Published: April 2024

Abstract
The revision of the Algerian Constitution of 30 December 2020 presented the Constitutional response to the institutional roadblocks and incoherencies within the hierarchy of norms brought to light by the Ḥirāk in 2019. The procedure used to revise the Constitution — an initiative of President Abdelmadjid Tebboune, rather than the election of a Constituent Assembly — has largely predetermined its content. The Army’s mission is now to defend “the country’s vital and strategic interests” (Article 30, para. 4), providing the retrospective legitimisation of its 2019 intervention to drive President Abdelaziz Bouteflika to step down. Furthermore, the amended Constitution makes it possible to pass legislation restricting fundamental rights and freedoms “for reasons linked to maintaining public order, security, and the protection of national constants” (Article 34, para. 2). This provision paves the way for the validation of oppressive laws applied or announced since 2019 with the aim of ending the Ḥirāk. This article argues that the Algerian Constitution no longer merely outlines a constitutionally ultra-Presidentialist regime, largely inherited from the 1976 Constitution, but an ultra-Presidentialist regime that is now also de jure militarised.
Gospel Truth in Gender Diversity Debates in Dutch Evangelical Churches
Authors: Dijkhuizen Laura 
Published: April 2024

Abstract
The inclusion of women in leadership navigates between the issues of unity and what is considered biblical. Recent empirical research in two evangelical churches in the Netherlands indicates that addressing female leadership as a secondary topic relative to the centrality of the gospel facilitates local churches to meet both values. The classification secondary is clarified as well as challenged by the evangelical definition of salvation. This article argues that a broader understanding of what is seen as the heart of the gospel might be beneficial in the approach to contemporary topics like gender roles in the church.
Matrix uncertainty in feeding-stuffs according to ISO 19036:2019
Authors: Wagner W. , Adler A. , Andreas B. , Breitenstein A. , Egert M. , Häger O. , Hahn A. , Neumann R. , Pickel B. , Strassgüttl J. , Weber M. , Wolf S. , Wolfram J. , Zecher K. , Zimmermann P. , Mietke H. 
Published: April 2024

Abstract
The combined measurement uncertainty of quantitative microbiological methods in the area of food and feed is calculated according to ISO 19036:2019 from the technical (intra-laboratory reproducibility standard deviation), the distributional and the matrix uncertainty (umatrix) of the respective sample type. The matrix uncertainty is a property of a certain sample type and independent of the individual laboratory and analysis, respectively. This study broadens the, so far, comparatively small data base on matrix uncertainties for feeding stuffs by investigating 20 representative feed types in 46 sample series. Thereby, difficulties and limitations arising from sample preparation, the selection of different microbial groups (bacteria and fungi) and the nature of different feed types are highlighted. In addition, the applicability with industrially added feed additives (e.g. probiotics) is discussed. In conclusion, the postulated independence and scope of the matrix uncertainty are limited in these respects.
The Islamic Principles of Legal Status Criteria according to the Qurʾan and Hadith in Fostering Ḥalāl Vaccine Certification in Malaysia
Authors: Ab Latiff Johari , Zakaria Zalina , Man Saadan 
Published: April 2024

Abstract
In Malaysia, there is a need to provide ḥalāl certification for vaccine products. In 2019, the Department of Islamic Development Malaysia (JAKIM), together with other relevant government agencies and the pharmaceutical industry, improved and expanded the scope and standards of Malaysian Standard MS 2424 Halal Pharmaceuticals-General Requirements, which serves as a general reference for ḥalāl pharmaceutical and vaccine products. It is a step in the right direction. However, ḥalāl certification for vaccine products cannot be implemented due to the lack of a clear legal framework based on Islamic principles derived from Qurʾan, Hadith, and other related legal sources. Furthermore, before this, the status of vaccine products was established through fatwas issued by the authority and not through the ḥalāl certification process. This is because, if ḥalāl certification is given to vaccine products, there may be public rejection of vaccine products that do not have ḥalāl certification, and this could occur during a public health emergency. The objective of this study was to analyse the Islamic principles in determining the ḥalāl vaccine certification. To achieve this objective, qualitative approaches have been used in this research. Data were collected through document analysis and semi-structured interviews with individuals directly involved in the ḥalāl vaccines sector in Malaysia. The findings of this study show that, in implementing ḥalāl vaccine certification, there are several Islamic principles based on Qurʾan and Hadith that can be used in the certification of ḥalāl vaccine products. These include the Principle of Ḥalāl Substances, Ḍarūrah, Maṣlaḥah, Iḥtiyāṭ, Istiḥālah Tāmmah, Istiḥlāk and Fatwā.
The Depth Dimension of Ricoeur’s Philosophy of Imagination
Authors: Taylor George H. 
Published: April 2024

Abstract
Implicit in Paul Ricoeur’s Lectures on Imagination is a depth dimension of the productive imagination that unfolds its sources that transfigure reality. The first part of the present essay introduces the problematic of the imagination to which Ricoeur seeks to respond: imagination has been viewed as derivative from perception or the concept and so is merely reproductive. Part two addresses how for Ricoeur the intertwining of experience and meaning allows an opening for the productive imagination to function. This subtext in the Lectures is extended by reference to Ricoeur’s greater exposition elsewhere on the symbolic mediation of action. Part three returns to the Lectures and its appraisal of productive imagination as the “nowhere” and seeks to develop what this nowhere as a point of origin might comprise. Part four draws upon Ricoeur’s work on the religious imagination to extend the nature of the productive imagination and its inspirations.
Co-occurring psychological distress and alcohol or other drug use among Indigenous Australians: Data from the National Aboriginal and Torres Strait Islander Health Survey
Authors: Hobden Breanne , Bryant Jamie , Davis Robert , Heard Todd , Rumbel Jenn , Newman Jamie , Rose Bron , Lambkin David , Sanson-Fisher Rob , Freund Megan 
Published: April 2024

Objectives: To determine the prevalence and demographic, social and health characteristics associated with co-occurring psychological distress symptoms, risky alcohol and/or substance use among a national sample of Aboriginal and Torres Strait Islander people aged 15 years or older. Methods: This study uses secondary cross-sectional data from the 2018-19 National Aboriginal and Torres Strait Islander Health Survey (NATSIHS). Data were collected via face-to-face interviews with those living in private dwellings across Australia. Participants were Aboriginal and Torres Strait Islander people ( n = 10,579) aged 15 years or older. Data pertaining to psychological distress, alcohol and substance use were obtained and weighted to represent the total population of Aboriginal and Torres Strait Islander people in Australia. Results: A total of 20.3% participants were found to have co-occurring psychological distress, risky alcohol use and/or substance use, and 4.0% reported co-occurrence of all three conditions. Female participants in a registered marriage and fully engaged in study or employment had lower rates of co-occurring conditions. Poorer self-rated health, one or more chronic conditions and increased experiences of unfair treatment and physical harm in the past 12 months were associated with increased rates of co-occurring conditions. Conclusion: A range of potential risk and protective factors were identified for co-occurring psychological distress, risky alcohol and/or substance use among Aboriginal and Torres Strait Islander people. This information is critical for planning effective holistic strategies to decrease the burden of suffering imposed upon the individual, family and community members impacted by co-occurring conditions.
Concurrent effect of shear flow and CNT presence on crystallization behavior and electrical properties of polypropylene based nanocomposites: A comprehensive structure-property investigation
Authors: Alimoradi Younes , Nourisefat Maryam , Farzaneh Arman , Nazokdast Hossein 
Published: April 2024

The loading of nanoparticle in the polymer matrix affects their response to shear flows applied during the fabrication process. With this in mind, in the present study, the concurrent effect of carbon nanotube (CNT) presence and shear application on the rheological and electrical properties as well as on the crystallization behavior of polypropylene (PP) based nanocomposites has been investigated. The results of rheological analyses showed that the solid-like behavior increases in proportion to the CNT content, and a remarkable increase in the solid-like behavior is obtained at a CNT content of 2 wt%. The isothermal crystallization results corroborated that crystallization temperature increases proportionally with the CNT content, however does not change with shearing. The non-isothermal crystallization findings confirmed that crystallization kinetics promotes with increasing CNT content, and this effect becomes more pronounced with shearing. The results of thermal analysis confirmed that the melting temperature decreases slightly, and the crystallinity remains almost unchanged with increasing CNT content up to 2%. However, when the CNT content rose up to 4%, the crystallinity decreased significantly due to confined crystallization. When this nanocomposite was subjected to shearing, the crystallinity increased. The results of electrical conductivity measurement revealed that the conductivity increases with increasing CNT content, while it decreases with shearing and the vulnerability of nanocomposites to shearing decreases with increasing CNT content.
Metabolic Rift and Structural Crisis of Capital: The Productive Specialization Pattern Based on Commodities and the Progressive Elimination of Ecological and Natural Resources in Brazil
Authors: Firmiano Frederico Daia , Teixeira Paula Maria Rattis 
Published: April 2024

In recent decades, Brazil has experienced a pattern of commodity-based productive specialization as part of the nation’s subordinate entry into the global structure of capital. As a result, the accumulation process has been based primarily on the intensive and extensive exploitation of available natural and ecological resources. From a historical perspective, we apply the theory of the metabolic rift and the structural crisis of capital to analyze the contemporary processes of social degradation of nature resulting from Brazil’s economic development. We focus on the cases of the Brazilian Amazon and Cerrado regions to examine the trend towards the progressive elimination of the elementary conditions for the social reproduction of life in the current stage of development of the productive forces on a global scale. Nas últimas décadas, o Brasil tem experimentado um padrão de especialização produtiva baseado em commodities, na presença de seu ingresso subordinado na estrutura global do capital. Com isso, o processo de acumulação tem se apoiado, dominantemente, sobre a exploração intensiva e extensiva dos recursos naturais e ecológicos disponíveis. Desde uma perspectiva histórica, mobilizamos a teoria da fenda metabólica e da crise estrutural do capital para analisar os processos contemporâneos de degradação social da natureza no curso do particular desenvolvimento econômico brasileiro. Lançamos luz nos casos da Amazônia e do Cerrado brasileiros para examinar a tendência à eliminação progressiva das condições elementares da reprodução social da vida no atual estágio do desenvolvimento das forças produtivas em escala global.