bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fugitive Figurations of Chronic Disability: Reconstructing Black Disability Politics in Frances Harper’s Iola Leroy
Authors: Knadler Stephen 
Published: February 2024

Abstract
“Fugitive Figurations of Chronic Disability: Re-Constructing the Black Disability Politics in Frances Harper’s Iola Leroy” fills a gap in nineteenth-century Black disability histories that have overlooked questions of chronic disabilities. In Iola Leroy, Harper writes from the perspective of the chronically disabled and offers fugitive figurations that exceed, resist, and stand apart from nineteenth-century representations of white true women’s invalidism and racial pathologizations. Harper uses Iola’s and other characters’ chronic debilities as a social location for imagining an alternative Black epistemology of the chronic with its own “phraseology” to testify to the inseparability of racial and disability justice as a part of Black freedom struggles. As part of its fugitive figurations of chronic disabilities, Iola Leroy also unbinds Black bodies and minds from a disciplinary individualistic productive capitalist time; and it centers an inclusive postbellum Black community of collective mutual care that exposes the limitations of a liberal (white) sentimental politics of sympathy. Harper’s fugitive figurations of chronic disability in Iola Leroy raise important questions about the methods critics use to recover Black disability in nineteenth-century US literature, methods which too often mine for present-day models of disabled medical verisimilitude and visibility rather than excavating the alternative figurations that Black writers such as Harper employed as part of twinned anti-ableist and anti-racist liberation and care practice.
Multiwavelength variability analysis of Fermi-LAT blazars
Authors: Peñil P , Otero-Santos J , Ajello M , Buson S , Domínguez A , Marcotulli L , Torres−Albà N , González J Becerra , Acosta-Pulido J A 
Published: February 2024

ABSTRACT
Blazars present highly variable gamma-ray emission. This variability, which can range from a few minutes to several years, is also observed at other wavelengths across the entire electromagnetic spectrum. We make use of the first 12 yr of data from the Fermi Large Area Telescope, complemented with multiwavelength (MWL) archival data from different observatories and facilities in radio, infrared, and optical bands, to study the possible periodic emission from 19 blazars previously claimed as periodic candidates. A periodicity analysis is performed with a pipeline for periodicity searches. Moreover, we study the cross-correlations between the gamma-ray and MWL light curves. Additionally, we use the fractional variability and the structure function to evaluate the variability time-scales. We find five blazars showing hints of periodic modulation with ≥3.0σ (≈0σ post-trials), with periods ranging from 1.2 to 4 yr, both in their gamma-ray and MWL emission. The results provide clues for understanding the physical mechanisms generating the observed periodicity.
Iron depletion in mineral dust grains from Saturn’s main rings
Authors: Linti Simon , Postberg Frank , Hsu Hsiang-Wen , Hillier Jon K , Fischer Christian , Trieloff Mario , Schmidt Jürgen , Kempf Sascha , Srama Ralf 
Published: February 2024

ABSTRACT
During the Grand Finale orbits, Cassini’s Cosmic Dust Analyzer (CDA) recorded in situ mass spectra of ice and mineral nanodust grains ejected from Saturn’s main rings falling into the planet’s atmosphere. We present a compositional analysis of the mineral dust fraction employing a spectral deconvolution method to determine the elemental composition of these grains. The results indicate a relatively homogenous composition of exclusively Mg-rich silicates, with Mg, Si, and Ca close to CI chondritic abundances but a significant depletion in Fe and only traces of organic material at best. The Fe depletion becomes even more pronounced when compared to Fe-rich interplanetary dust particles encountered by CDA in the Saturnian system, which are assumed to contaminate and darken the main rings over time. We discuss potential explanations for the depletion, from which we favour compositional alteration of the infalling dust grains by impact-triggered chemistry in combination with dynamical selection effects and instrumental bias as the most plausible ones. This might cause an accumulation of Fe in the main rings over time, most likely in the form of oxides.
Establishing accretion flares from supermassive black holes as a source of high-energy neutrinos
Authors: van Velzen Sjoert , Stein Robert , Gilfanov Marat , Kowalski Marek , Hayasaki Kimitake , Reusch Simeon , Yao Yuhan , Garrappa Simone , Franckowiak Anna , Gezari Suvi , Nordin Jakob , Fremling Christoffer , Sharma Yashvi , Yan Lin , Kool Erik C , Stern Daniel , Veres Patrik M , Sollerman Jesper , Medvedev Pavel , Sunyaev Rashid , Bellm Eric C , Dekany Richard G , Duev Dimitri A , Graham Matthew J , Kasliwal Mansi M , Kulkarni Shrinivas R , Laher Russ R , Riddle Reed L , Rusholme Ben 
Published: February 2024

ABSTRACT
The origin of cosmic high-energy neutrinos remains largely unexplained. For high-energy neutrino alerts from IceCube, a coincidence with time-variable emission has been seen for three different types of accreting black holes: (1) a gamma-ray flare from a blazar (TXS 0506+056), (2) an optical transient following a stellar tidal disruption event (TDE; AT2019dsg), and (3) an optical outburst from an active galactic nucleus (AGN; AT2019fdr). For the latter two sources, infrared follow-up observations revealed a powerful reverberation signal due to dust heated by the flare. This discovery motivates a systematic study of neutrino emission from all supermassive black hole with similar dust echoes. Because dust reprocessing is agnostic to the origin of the outburst, our work unifies TDEs and high-amplitude flares from AGN into a population that we dub accretion flares. Besides the two known events, we uncover a third flare that is coincident with a PeV-scale neutrino (AT2019aalc). Based solely on the optical and infrared properties, we estimate a significance of 3.6σ for this association of high-energy neutrinos with three accretion flares. Our results imply that at least ∼10 per cent of the IceCube high-energy neutrino alerts could be due to accretion flares. This is surprising because the sum of the fluence of these flares is at least three orders of magnitude lower compared to the total fluence of normal AGN. It thus appears that the efficiency of high-energy neutrino production in accretion flares is increased compared to non-flaring AGN. We speculate that this can be explained by the high Eddington ratio of the flares.
A chemodynamical analysis of bright metal-poor stars from the HESP-GOMPA survey – indications of a non-prevailing site for light r-process elements
Authors: Bandyopadhyay Avrajit , Beers Timothy C , Ezzeddine Rana , Sivarani Thirupathi , Nayak Prasanta K , Pandey Jeewan C , Saraf Pallavi , Susmitha Antony 
Published: February 2024

ABSTRACT
We present a comprehensive analysis of the detailed chemical abundances for a sample of 11 metal-poor, very metal-poor, and extremely metal-poor stars ([Fe/H] = −1.65 to [Fe/H] = −3.0) as part of the HESP-GOMPA (Galactic survey Of Metal Poor stArs) survey. The abundance determinations encompass a range of elements, including C, Na, Mg, Al, Si, Ca, Sc, Ti, Cr, Mn, Fe, Co, Ni, Cu, Zn, Sr, and Ba, with a subset of the brighter objects allowing for the measurement of additional key elements. Notably, the abundance analysis of a relatively bright highly r-process-enhanced (r-II) star (SDSS J0019+3141) exhibits a predominantly main r-process signature and variations in the lighter r-process elements. Moreover, successful measurements of thorium in this star facilitate stellar age determinations. We find a consistent odd–even nucleosynthesis pattern in these stars, aligning with expectations for their respective metallicity levels, thus implicating Type II supernovae as potential progenitors. From the interplay between the light and heavy r-process elements, we infer a diminishing relative production of light r-process elements with increasing Type II supernova contributions, challenging the notion that Type II supernovae are the primary source of these light r-process elements in the early Milky Way. A chemodynamical analysis based on Gaia astrometric data and our derived abundances indicates that all but one of our program stars are likely to be of accreted origin. Additionally, our examination of α-poor stars underscores the occurrence of an early accretion event from a satellite on a prograde orbit, similar to that of the Galactic disc.
Deciphering cometary outbursts: linking gas composition changes to trigger mechanisms
Authors: Müller Daniel R , Altwegg Kathrin , Berthelier Jean-Jacques , Combi Michael R , De Keyser Johan , Fuselier Stephen A , Garnier Philippe , Hänni Nora , Mall Urs , Rubin Martin , Wampfler Susanne F , Wurz Peter 
Published: February 2024

ABSTRACT
Dust and gas outbursts are recurrent cometary phenomena, playing a crucial role in shaping the coma. Proposed outburst trigger mechanisms include cliff collapse, pressure pockets, and amorphous-to-crystalline phase transition of water ice; however, the underlying processes remain inadequately understood. In this study, we analyse Rosetta/ROSINA data from multiple outbursts on comet 67P/Churyumov-Gerasimenko and present the evolution of the gas composition in the comet’s coma during outburst events. We distinguish two distinct categories of cometary outbursts on the comet: water-driven events characterized by rapid (minutes to hours) changes in coma composition, and CO2-driven events displaying a slow, prolonged (hours to days) increase in highly volatile species. We tentatively associate these different gas composition patterns with different trigger mechanisms. Exposure of fresh ice due to cliff collapse leads to a notable water enhancement, while most perihelion outbursts coincide with substantial density increases of CO2. We propose that these CO2-driven events originate from subsurface gas-filled cavities, whose walls are suggested to have been sealed by earlier refreezing of CO2 migrating from warmer spots, hence increasing the cavity pressure required to burst.
Constraining ultralight axions with CSST weak gravitational lensing and galaxy clustering photometric surveys
Authors: Lin Hengjie , Deng Furen , Gong Yan , Chen Xuelei 
Published: February 2024

ABSTRACT
Ultralight axion (ULA) can be one of the potential candidates for dark matter. The extremely low mass of the ULA can lead to a de Broglie wavelength the size of galaxies which results in a suppression of the growth of structure on small scales. In this work, we forecast the constraint on the ULA particle mass ma and relative fraction to dark matter fa = Ωa/Ωd for the forthcoming Stage IV space-based optical survey equipment CSST (China Space Station Telescope). We focus on the CSST cosmic shear and galaxy clustering photometric surveys, and forecast the measurements of shear, galaxy, and galaxy–galaxy lensing power spectra (i.e. 3 × 2 pt). The effects of neutrino, baryonic feedback, and uncertainties of intrinsic alignment, shear calibration, galaxy bias, and photometric redshift are also included in the analysis. After performing a joint constraint on all the cosmological and systematical parameters based on the simulated data from the theoretical prediction, we obtain a lower limit of the ULA particle mass log10 (ma/eV) ≥ −22.5 and an upper limit of the ULA fraction fa ≤ 0.83 at 95 per cent confidence level, and log10 (ma/eV) ≥ −21.9 with fa ≤ 0.77 when ignoring the baryonic feedback. We find that the CSST photometric surveys can improve the constraint on the ULA mass by about one order of magnitude, compared to the current constraints using the same kind of observational data.
Novel insights into the role of translesion synthesis polymerase in DNA incorporation and bypass of 5-fluorouracil in colorectal cancer
Authors: Averill Jameson R , Lin Jackson C , Jung John , Jung Hunmin 
Published: February 2024

Abstract
5-Fluorouracil (5-FU) is the first-line chemotherapeutic agent in colorectal cancer, and resistance to 5-FU easily emerges. One of the mechanisms of drug action and resistance of 5-FU is through DNA incorporation. Our quantitative reverse-transcription PCR data showed that one of the translesion synthesis (TLS) DNA polymerases, DNA polymerase η (polη), was upregulated within 72 h upon 5-FU administration at 1 and 10 μM, indicating that polη is one of the first responding polymerases, and the only TLS polymerase, upon the 5-FU treatment to incorporate 5-FU into DNA. Our kinetic studies revealed that 5-fluoro-2′-deoxyuridine triphosphate (5FdUTP) was incorporated across dA 41 and 28 times more efficiently than across dG and across inosine, respectively, by polη indicating that the mutagenicity of 5-FU incorporation is higher in the presence of inosine and that DNA lesions could lead to more mutagenic incorporation of 5-FU. Our polη crystal structures complexed with DNA and 5FdUTP revealed that dA:5FdUTP base pair is like dA:dTTP in the active site of polη, while 5FdUTP adopted 4-enol tautomer in the base pairs with dG and HX increasing the insertion efficiency compared to dG:dTTP for the incorrect insertions. These studies confirm that polη engages in the DNA incorporation and bypass of 5-FU.
Comprehensive map of ribosomal 2′-O-methylation and C/D box snoRNAs in Drosophila melanogaster
Authors: Sklias Athena , Cruciani Sonia , Marchand Virginie , Spagnuolo Mariangela , Lavergne Guillaume , Bourguignon Valérie , Brambilla Alessandro , Dreos René , Marygold Steven J , Novoa Eva Maria , Motorin Yuri , Roignant Jean-Yves 
Published: February 2024

Abstract
During their maturation, ribosomal RNAs (rRNAs) are decorated by hundreds of chemical modifications that participate in proper folding of rRNA secondary structures and therefore in ribosomal function. Along with pseudouridine, methylation of the 2′-hydroxyl ribose moiety (Nm) is the most abundant modification of rRNAs. The majority of Nm modifications in eukaryotes are placed by Fibrillarin, a conserved methyltransferase belonging to a ribonucleoprotein complex guided by C/D box small nucleolar RNAs (C/D box snoRNAs). These modifications impact interactions between rRNAs, tRNAs and mRNAs, and some are known to fine tune translation rates and efficiency. In this study, we built the first comprehensive map of Nm sites in Drosophila melanogaster rRNAs using two complementary approaches (RiboMethSeq and Nanopore direct RNA sequencing) and identified their corresponding C/D box snoRNAs by whole-transcriptome sequencing. We de novo identified 61 Nm sites, from which 55 are supported by both sequencing methods, we validated the expression of 106 C/D box snoRNAs and we predicted new or alternative rRNA Nm targets for 31 of them. Comparison of methylation level upon different stresses show only slight but specific variations, indicating that this modification is relatively stable in D. melanogaster. This study paves the way to investigate the impact of snoRNA-mediated 2′-O-methylation on translation and proteostasis in a whole organism.
Are IMF programs raising greenhouse gas emissions in the Global South?
Authors: Soener Matthew 
Published: February 2024

Abstract
Are International Monetary Fund (IMF) programs raising greenhouse gas emissions in the Global South? I argue powerful actors structure markets in ways exacerbating climate change. This works through the IMF’s imposition of market coercion—specifically, currency devaluation, global openness and fiscal pressures from austerity. Countries respond to these conditions through extractivist strategies and productive growth to increase exports. To investigate this relationship, I use instrumental variables and difference-in-difference analyses for 130 countries between 1980 and 2018. Results show emissions increase from structural lending conditions but not when conditions afford borrowers more flexibility. This effect takes several years to manifest. While there is no single sector responsible for this change, agriculture, land-use changes and, to some extent, industry, have notable emission effects following an IMF program. Global South emissions are partly rooted in imposed austerity which raises important political questions about the climate crisis, development and international finance.
Making Use of Natural Language Processing to Better Understand Medical Students’ Self-Assessment of Clinical Skills
Authors: Turner Laurah , Weber Danielle E. , Santen Sally A. , Olex Amy L. , Baker Pamela , Overla Seth , Shu Derek , Randolph Anne , Kelleher Matt 
Published: February 2024

Abstract

Problem
Reflective practice is necessary for self-regulated learning. Helping medical students develop these skills can be challenging since they are difficult to observe. One common solution is to assign students’ reflective self-assessments, which produce large quantities of narrative assessment data. Reflective self-assessments also provide feedback to faculty regarding students’ understanding of content, reflective abilities, and areas for course improvement. To maximize student learning and feedback to faculty, reflective self-assessments must be reviewed and analyzed, activities that are often difficult for faculty due to the time-intensive and cumbersome nature of processing large quantities of narrative assessment data.

Approach
The authors collected narrative assessment data (2,224 students’ reflective self-assessments) from 344 medical students’ reflective self-assessments. In academic years 2019–2020 and 2021–2022, students at the University of Cincinnati College of Medicine responded to 2 prompts (aspects that surprised students, areas for student improvement) after reviewing their standardized patient encounters. These free-text entries were analyzed using TopEx, an open-source natural language processing (NLP) tool, to identify common topics and themes, which faculty then reviewed.

Outcomes
TopEx expedited theme identification in students’ reflective self-assessments, unveiling 10 themes for prompt 1 such as question organization and history analysis, and 8 for prompt 2, including sensitive histories and exam efficiency. Using TopEx offered a user-friendly, time-saving analysis method without requiring complex NLP implementations. The authors discerned 4 education enhancement implications: aggregating themes for future student reflection, revising self-assessments for common improvement areas, adjusting curriculum to guide students better, and aiding faculty in providing targeted upcoming feedback.

Next Steps
The University of Cincinnati College of Medicine aims to refine and expand the utilization of TopEx for deeper narrative assessment analysis, while other institutions may model or extend this approach to uncover broader educational insights and drive curricular advancements.
Learner Experiences of Preceptor Self-Disclosure of Personal Illness in Medical Education
Authors: Ene Ioana Cezara , Kocaqi Etri , Acai Anita 
Published: February 2024

AbstractPurposeThe notion of physician invulnerability to illness contributes to the ongoing marginalization of physicians with personal experiences of illness and complicates professional identity development in medical learners. As such, physician self-disclosure of lived experiences as patients has seen an increasing role in medical education. Existing literature, centered on mental health, has characterized the positive effect of physician discussion of experience with mental illness on medical students and residents. However, the ways learners process and understand physician illness stories beyond this context and their use in education remain unclear. This study aimed to explore undergraduate medical students’ perspectives on physician illness discussions of both physical and mental illness, including their perceptions of its use as a pedagogical tool.MethodThis qualitative study followed an interpretive descriptive design using activity theory as a sensitizing concept. Semistructured interviews with medical students were conducted between January and April 2022 at McMaster University in Hamilton, Ontario, Canada. The authors analyzed transcripts using reflexive thematic analysis.ResultsTwenty-one medical students participated in interviews. Although rare, self-disclosure conversations occurred across varied settings and addressed diverse aspects of illness experiences. Discussions involved teaching of pathophysiology, career advice, and wellness guidance. Five themes were developed: the opposition of physicianhood, patienthood, and situating the learner identity; invisibility and stigmatization of physician illness; impact of preceptor stories on learners’ relationship with medicine; challenging the “rules” of physicianhood; and situating self-disclosure in medical education.ConclusionsStudents strongly appreciated physician self-disclosure conversations. Self-disclosure can act as an effective pedagogical tool by fostering expansive learning among medical students. Further research is necessary to explore physician perspectives and supports for self-disclosure in education.
Familial Intraductal Papillary Mucinous Neoplasm Associated With the Germline MSH6 Missense Variant and Progression of Pancreatic cancer
Authors: Tezuka Koji , Yamakawa Mitsunori , Murakami Ryoko , Hirai Ichiro , Toya Ryo , Suzuki Akihiko , Kawamura Hiroshi , Miyano Yuki , Sato Hidenori , Motoi Fuyuhiko 
Published: February 2024

Objectives
Intraductal papillary mucinous neoplasm (IPMN) in individuals with at least one first-degree relative with IPMN is defined as familial IPMN. However, few studies have reported on familial IPMN, its clinical characteristics, or the associated genetic factors.

Materials and Methods
We report the case of a 58-year-old woman with multifocal IPMN and a mural nodule in the pancreatic body. The patient underwent a distal pancreatectomy and developed pancreatic head cancer 1 year and 6 months postoperatively. The patient had a family history of multifocal IPMN in her father. Therefore, a genetic predisposition to IPMN and pancreatic cancer was suspected. The patient was analyzed for germline variants, and the resected IPMN was subjected to immunohistochemical and somatic variant analyses.

Results
Next-generation sequencing revealed a heterozygous germline missense variant in exon 5 of MSH6 (c.3197A>G; Tyr1066Cys). The pathogenicity of this variant of uncertain significance was suspected based on multiple in silico analyses, and the same MSH6 variant was identified in the patient's father's colonic adenoma. The mural nodule in the pancreatic body was pathologically diagnosed as a high-grade IPMN with ossification and somatic KRAS and PIK3CA variants.

Conclusions
This case revealed a possible genetic factor for familial IPMN development and presented interesting clinicopathological findings.