bluuebunny/crossref_metadata_2025_split huggingface dataset:
Performance of preferentially expressed antigen in melanoma (PRAME) immunohistochemistry for metastatic melanoma in cytology specimens
Authors: Saad Mohammed , Cantley Richard , Hao Wei , Wang Zixi , Thomas Dafydd , Pantanowitz Liron , Jin Xiaobing 
Published: April 2024

AbstractBackgroundPreferentially expressed antigen in melanoma (PRAME) has been introduced as a new melanoma marker and potential target for immunotherapy. While PRAME immunohistochemistry (IHC) is well documented in surgical pathology, similar data in cytology are limited. Metastatic melanoma is frequently diagnosed via cytology samples in which IHC plays an important role. We aimed to accordingly evaluate the performance of PRAME IHC in diagnosing metastatic melanoma in cytology samples relative to other commonly used melanoma markers.Materials and MethodsThe study included 156 archival cytology cases, of which 93 were melanoma cases and 63 nonmelanoma cases (controls). All cases underwent PRAME IHC staining on cell blocks. Nuclear staining of PRAME was evaluated using a quantitative and qualitative scale. Other melanocytic IHC stain results (SOX10, S‐100, Melan‐A, and HMB45) were also documented.ResultsPRAME was detected in tumor cells in 86% of melanoma cases, which was significantly lower than SOX10 (100%) (p < .01), and similar to HMB45 (84%) and Melan‐A (82%). S‐100 had the lowest sensitivity of 71%. In comparison to other types of melanomas, spindle cell melanoma exhibited higher negativity for PRAME IHC (4/10 = 40%). PRAME was also expressed in some nonmelanocytic malignancies including carcinoma (5/22 = 23%), sarcoma (5/15 = 33%), and hematologic malignancies (1/9 = 11%). Overall, PRAME showed a sensitivity of 86%, specificity of 82%, positive predictive value of 70%, and negative predictive value of 92% for metastatic melanoma.ConclusionsPRAME is a useful marker for the diagnosis of melanoma in cytology material, but it is less sensitive than SOX10. PRAME is also expressed in other nonmelanocytic tumors which limits its specificity.
Patients' perceptions of post‐treatment factors that influenced skill use after cognitive‐behavioral therapy for bulimia nervosa spectrum disorders
Authors: Liu Jianyi , Wang Hailing , Wetherall Lucy , Giannone Alyssa , Juarascio Adrienne 
Published: April 2024

AbstractObjectiveDeterioration rate among patients with bulimia‐spectrum eating disorders (BN‐EDs) after receiving enhanced cognitive‐behavioral therapy (CBT‐E) remains high. Previous studies identified body image concerns, environmental triggers, lack of social support, lack of resources, comorbidity, and discontinued skill use as predictors of deterioration. However, no studies have qualitatively explored patients' perceptions of how these factors influenced their skill use and led to deterioration after receiving outpatient CBT.MethodsThis study aimed to qualitatively explore (1) what post‐treatment factors patients believe contributed to deterioration, and (2) whether patients continued to practice the CBT skills they learned from treatment and identify motivators and barriers to post‐treatment skill use. Twelve participants who had previously completed 16 sessions of CBT for their BN‐EDs and experienced at least modest treatment responses participated in the qualitative interviews.ResultsFour themes were identified from the qualitative interviews. Post‐treatment deterioration was primarily driven by decreased skill use due to a perceived sudden loss of accountability and continued body dissatisfaction after treatment ended. Discontinued practice of binge analysis led to decreased awareness of the relationship between poor skill use and ED behaviors. Difficulty accessing resources impeded participants from receiving external help to address challenges in skill practice, thus also contributing to deterioration.DiscussionFindings suggested that outpatient treatment for BN‐EDs patients should emphasize more on body image concern, and deterioration prevention for outpatient CBT‐E should focus on building self‐accountability to keep practicing skills after treatment ends.Public significanceThis study was the first to qualitatively explore post‐treatment factors influencing skill use and deterioration in patients with bulimia‐spectrum eating disorders after they completed outpatient CBT. Findings indicated that decreased skill use was a primary driver of post‐treatment deterioration, and that relapse prevention for outpatient CBT for BN‐EDs should focus on enhancing patients' self‐accountability to continue practicing therapeutic skills independently after treatment ended.
Direct and Stereoselective Protecting‐Group‐Free N‐ADP‐Ribosylation through Traceless Staudinger Ligation
Authors: Hagino Rui , Komura Naoko , Imamura Akihiro , Ishida Hideharu , Ando Hiromune , Tanaka Hide‐Nori 
Published: April 2024

AbstractAdenine diphosphate (ADP)‐ribosylation catalyzed by bacterial toxins is the addition of an ADP‐ribose moiety to specific amino acid residues in target proteins such as arginine, asparagine, glutamine, and histidine through 1,2‐cis(α)‐glycosidic bond formation. ADP‐ribosylation modifies host cell functions, altering normal cellular processes to facilitate their survival, and replication. Despite the development of click chemistry and solid‐phase peptide synthesis‐based approaches, the synthesis of structurally well‐defined naturally occurring N‐linked ADP‐ribosyl molecules remains challenging. Herein, we report a direct and α‐selective N‐ADP‐ribosylation using unprotected β‐ADP‐ribosyl azide and triphenylphosphine esters through traceless Staudinger ligation. The stereoselectivity of this protecting‐group‐free N‐ADP‐ribosylation was validated by enzymatic degradation experiment and high‐performance liquid chromatography, referencing synthetic standards. This method facilitated the facile and rapid synthesis of N‐ADP‐ribosyl acetamide, biotin, fluorescent dye, amino acids, and tripeptide with complete α‐selectivity and moderate yields (37–55 %).
Enhancing performance of two‐step fabricated perovskite solar cells with sulfonium triflate‐based additive
Authors: Kim Yeeun , Lee Hyunjun , Lee Cheongbeom , Kim Beomjin , Kwon Nayoon , Son Taewoong , Lee Jaehee , Sin Jaegwan , Shin Taejoo , Yang Jungyup , Kim Kyeounghak , Seo Jangwon 
Published: April 2024

AbstractWe incorporated triphenylsulfonium triflate (TPST), a sulfonium‐based additive consisting of polar triflate and bulky hydrophobic phenyl rings, to the PbI2 precursor solution for preparation of less‐defect perovskite film via two‐step fabrication. TPST induced localized alterations in the array of the PbI2 structure due to its large size, thereby forming a more discontinuous and coarser surface with a greater number of pinholes and subsequently facilitating more efficient organic–inorganic reactions. As a result, we achieved the production of thick perovskite films with enlarged granules and decreased PbI2 residuals in the two‐step fabrication process. Furthermore, TPST facilitated the passivation of bulk film defects by increasing the binding energy with the defects. Consequently, the ITO/SnO2 np‐based device and the FTO/CBD SnO2‐based device obtained the best PCEs of 23.88% and 24.30%, respectively. Furthermore, the moisture stability of the perovskite was improved by the hydrophobic character of the TPST additive.image
Personality traits and the risk of urinary incontinence: Evidence from three longitudinal samples
Authors: Stephan Yannick , Sutin Angelina R. , Terracciano Antonio 
Published: April 2024

AbstractObjectiveUrinary incontinence (UI) is a common condition with a substantial negative impact on older adults' quality of life. This study examines whether individual differences in behavioral, cognitive, and emotional traits assessed by the five major dimensions of personality are related to the risk of concurrent and incident UI.MethodsParticipants were older women and men (N > 26,000) from the Midlife in the United States Survey, the Health and Retirement Study, and the English Longitudinal Study of Aging. In each cohort, personality traits (measured with the Midlife Development Inventory) and demographic (age, sex, education, and race), clinical (body mass index, diabetes, blood pressure), and behavioral (smoking) factors were assessed at baseline. UI was assessed at baseline and again 8–20 years later. Results for each cohort were combined in random‐effect meta‐analyses.ResultsConsistently across cohorts, higher neuroticism and lower conscientiousness were related to a higher risk of concurrent and incident UI. To a lesser extent, extraversion, openness, and agreeableness were also related to lower risk of concurrent and incident UI. BMI, diabetes, blood pressure, and smoking partially accounted for these associations. There was little evidence that age or sex moderated the associations.ConclusionsThe present study provides novel, robust, and replicable evidence linking personality traits to UI. The higher vulnerability for UI for individuals who score higher on neuroticism and lower on conscientiousness is consistent with findings for other multifactorial geriatric syndromes. Personality traits can help identify individuals at risk and may help contextualize the clinical presentation of comorbid emotional, cognitive, and behavioral symptoms.
Circulating tumor plasma cells and peripheral blood measurable residual disease assessment in multiple myeloma patients not planned for upfront transplant
Authors: Tembhare Prashant R. , Sriram Harshini , Khanka Twinkle , Gawai Sanghamitra , Bagal Bhausaheb , Ghogale Sitaram G. , Deshpande Nilesh , Girase Karishma , Patil Jagruti , Hasan Syed Khaizer , Shetty Dhanalaxmi , Ghosh Kinjalka , Chatterjee Gaurav , Rajpal Sweta , Patkar Nikhil V. , Jain Hasmukh , Punatar Sachin , Gokarn Anant , Nayak Lingaraj , Mirgh Sumeet , Jindal Nishant , Sengar Manju , Khattry Navin , Subramanian Papagudi G. , Gujral Sumeet 
Published: April 2024

AbstractCirculating tumor plasma cells (CTPCs) provide a noninvasive alternative for measuring tumor burden in newly diagnosed multiple myeloma (NDMM). Moreover, measurable residual disease (MRD) assessment in peripheral blood (PBMRD) can provide an ideal alternative to bone marrow MRD, which is limited by its painful nature and technical challenges. However, the clinical significance of PBMRD in NDMM still remains uncertain. Additionally, data on CTPC in NDMM patients not treated with transplant are scarce. We prospectively studied CTPC and PBMRD in 141 NDMM patients using highly sensitive multicolor flow cytometry (HS‐MFC). PBMRD was monitored at the end of three cycles (PBMRD1) and six cycles (PBMRD2) of chemotherapy in patients with detectable baseline CTPC. Patients received bortezomib‐based triplet therapy and were not planned for an upfront transplant. Among baseline risk factors, CTPC ≥ 0.01% was independently associated with poor progression‐free survival (PFS) (hazard ratio [HR] = 2.77; p = 0.0047) and overall survival (OS) (HR = 2.9; p = 0.023) on multivariate analysis. In patients with detectable baseline CTPC, undetectable PBMRD at both subsequent time points was associated with longer PFS (HR = 0.46; p = 0.0037), whereas detectable PBMRD at any time point was associated with short OS (HR = 3.25; p = 0.004). Undetectable combined PBMRD (PBMRD1 and PBMRD2) outperformed the serum‐immunofixation‐based response. On multivariate analysis, detectable PBMRD at any time point was independently associated with poor PFS (HR = 2.0; p = 0.025) and OS (HR = 3.97; p = 0.013). Thus, our findings showed that CTPC and PBMRD assessment using HS‐MFC provides a robust, noninvasive biomarker for NDMM patients not planned for an upfront transplant. Sequential PBMRD monitoring has great potential to improve the impact of the existing risk stratification and response assessment models.
Workplace violence against healthcare workers in the emergency department in Hong Kong
Authors: Chang Hiu Tung , Lam Tommy Shing Kit , Chu Manson Cheuk Man 
Published: April 2024

AbstractIntroductionWorkplace violence affects the dignity and well‐being of healthcare workers and poses threats to the efficiency and success of the healthcare system. Healthcare workers in the emergency department (ED) are known to be vulnerable to workplace violence. This study explored the prevalence of workplace violence in the ED in Hong Kong and factors associated with self‐reported workplace violence.MethodsAn anonymous, voluntary, self‐administered and web‐based cross‐sectional survey was carried out from 1 June to 30 June 2022 among doctors and nurses in three regional EDs. Multivariable logistic regression analyses were conducted to examine the factors associated with workplace violence.ResultsA total of 162 healthcare workers including 57 doctors and 105 nurses participated in the study, with an overall response rate of 50.8%. The overall prevalence of workplace violence was 66.7%. Verbal abuse (64.2%) was more common than physical violence (20.4%). Nursing group was significantly correlated with physical violence (aOR 7.27, p = 0.005). Reporting rate of workplace violence remained low (18.2% for physical violence and 12.5% for verbal abuse). More than half of the participants with experience of workplace violence reported that the incident affected their mental well‐being.ConclusionsWorkplace violence was a significant concern in the local ED and under‐reporting was not uncommon. Impact of workplace violence on healthcare workers and the healthcare system should be well recognised. Workplace violence protocol and prevention strategies are crucial.
Restorabite™: Phase II trial of jaw stretching exercises using a novel device for patients with trismus following head and neck cancer
Authors: Charters Emma , Cheng Kai , Dunn Masako , Heng Caleb , Loy Jamie , Ricketts Virginia , Luo Aaron , Aung Yee Mon , Lewin Will , Howes Dale , Manzie Timothy , Wan Boyang , Clark Jonathan 
Published: April 2024

AbstractPatients treated for oral cancer, may experience restricted mouth opening (trismus). Barriers such as cost have limited the utilization of traditional jaw stretching devices, and consequently, patients experience problems with swallowing, oral care, communication, and cancer surveillance. The safety and efficacy of Restorabite™, a new device designed to overcome these barriers, is evaluated prospectively over 12 months. This phase II investigator‐led trial included patients with chronic trismus underwent 10‐weeks of trismus therapy using Restorabite™. Safety, adherence, changes in mouth opening, and patient‐reported outcomes are presented. 114/120 participants with trismus completed the intervention, and 104 had their progress monitored for 12 months. Thirteen participants withdrew due to tumour recurrence. At the completion of the intervention, mouth opening improved by 10.4 mm (p < .001). This increased to 13.7 mm at 12 months (p < .001). Patient reported outcome all significantly improved and 47 participants were no longer classified as having trismus. There were no serious treatment related adverse events. In patients with trismus following head and neck cancer treatment, a 10‐week programme of jaw stretching exercises using Restorbite™ safely improves mouth opening and associated quality of life outcomes with high adherence and the benefits are maintained for 12‐months.
A rare case of a testicular lesion related to hand, foot, and mouth disease
Authors: Igarashi Ayaka , Takezawa Yutaka , Ozawa Yuki , Saito Tomomi , Nakayama Hiroshi , Makino Takeaki , Etsunaga Toru , Saito Yoshitaka , Kobayashi Mikio 
Published: April 2024

IntroductionHand, foot, and mouth disease generally occurs in children. In rare cases, hand, foot, and mouth disease affects the testicles.Case presentationA 29‐year‐old man presented to our emergency department with testicular pain for several days after the onset of hand, foot, and mouth disease. Ultrasonography revealed hypoechoic mass‐like areas in the right testis. A mild inflammatory response was noted, tumor markers and urinary data were normal, and tests for infection were all negative. Antibiotics were initiated and ultrasonography was performed in every subsequent examination. Testicular pain disappeared 6 months later.ConclusionWe encountered a rare case of a testicular lesion related to hand, foot, and mouth disease that was successfully treated. The careful selection of treatment for testicular pain and scrotal enlargement in young adult males, such as surgery and symptomatic treatment, based on their medical history and laboratory findings, is important.
A hybrid convolutional and transformer network for segmentation of coronary computed tomography angiographic slices
Authors: Duan Xiaojie , Wang Yanchao , Wang Jianming 
Published: April 2024

AbstractCoronary artery three‐dimensional reconstruction is essential for preventing, diagnosing, and treating coronary heart disease. This study introduces SegUnet, a lightweight hybrid CNN‐Transformer network for pixel‐level segmentation of coronary artery computed tomography angiography (CTA) slices to enhance the precision of coronary artery reconstruction. The overall SegUnet adopts a U‐shaped encoder‐decoder structure, with a hierarchical Transformer structure serving as the encoder to extract global contextual information; the decoder is enhanced with spatial attention mechanism (SAM) and residual structure to improve its perception and adaptive adjustment abilities for coronary artery vessels. In contrast to other methods, we propose an interpolation‐based multi‐feature fusion bridge to integrate multi‐scale features between encoder levels, capturing their semantic dependencies. Experimental results show that SegUnet achieves a prediction accuracy of 97.23% on the test set of coronary arteries 2D slices. Moreover, the network exhibits excellent performance on Synapse Multi‐Organ Segmentation, highlighting the superiority, effectiveness, and robustness of our proposed method. The outstanding performance of SegUnet in coronary artery segmentation has elevated the quality of three‐dimensional reconstruction of the coronary arteries, exerting a positive impact on the enhancement of diagnosis and treatment of coronary artery diseases.
Re‐examining the relationship between patience, risk‐taking, and human capital investment across countries*
Authors: de Gendre Alexandra , Feld Jan , Salamanca Nicolás 
Published: April 2024

SummaryHanushek et al. (2022) show that students in countries in which people are more patient and less risk‐taking perform better in the Programme for International Student Assessment (PISA) test. In this paper, we probe the robustness of this study. Our narrow replication shows that most of the results are robust to alternative model specifications. Our broad replication shows that the main results are robust to measuring student performance with data from the Trends in International Mathematics and Science Study (TIMSS) and the Progress in International Reading Literacy Study (PIRLS) instead of PISA.
Person‐first language and addiction literature: The presence of labeling and emotional language in counseling articles
Authors: Ricciutti Natalie M. , Davis Willough 
Published: April 2024

AbstractThe purpose of this study was to determine the rate and frequency of labeling language, emotional language, and person‐first language (PFL) toward individuals with substance use disorders and addictions in articles published in 24 counseling journals. Of the 249 articles reviewed, 61.04% did not fully adhere to PFL, while 34.54% included labeling language and 51.41% included emotional language. A significant positive correlation was found between the use of labeling language and emotional language. Implications for practicing counselors, counselor educators, and researchers are provided. We advocate for the use of PFL toward those with addictions in published works and in conversations.
A review of counseling research using single‐case research design
Authors: Brown Cian L. , Peltier Corey , Smarinsky Evan C. , Lewis Olivia J. , Lee David Y. 
Published: April 2024

AbstractSingle‐case research designs (SCRDs) are a vital tool for researchers and practitioners in counseling to evaluate intervention and treatment effectiveness. This content analysis reviews the application of SCRDs in counseling to highlight knowledge accrued and existing gaps in the literature. We evaluated the methodological design and reporting adherence against recommended guidelines to provide guidance for future research. We included 50 SCRDs published between 2015 and 2021 across 15 journals (42 reviewed). Content results showed several trends, strengths, and areas of improvement in counseling SCRDs. No studies completely met the What Works Clearinghouse (2022) design standards or Single‐Case Reporting Guideline in Behavioural Interventions (SCRIBE) reporting standards, yet several indicators had high levels of adherence. We discuss how the experimental design process can be enhanced to improve the internal validity, ways to improve transparency in reporting SCRD results, and the importance of contextualizing SCRD methodology to the counseling field.
Clinical evaluation on the use of a new accessory device for Fox plane
Authors: Nakano Leonardo Jiro Nomura , Soares Milena Pereira da Silva , Kukulka Elisa Camargo , Lima Beatriz Samara de Souza , Gomes Michelle de Sá dos Santos , Paes Júnior Tarcisio de Arruda 
Published: April 2024

AbstractObjectiveEvaluate the assimilation capacity and ease of handling of the Fox plane accessory by dentistry students, through a questionnaire about the experience in using this device compared to the conventional one. Its intention is to minimize possible interpretation errors and challenges that the traditional method determines.MethodsAfter approval by the Research Ethics Committee, registration at Sistema Nacional de Informações sobre Ética em Pesquisa/National Information System on Research Ethics (SISNEP) and signing of the free and informed consent form, 51 undergraduate students treating patients in need of complete dentures at Instituto de Ciência e Tecnologia/Institute of Science and Technology (ICT) Unesp in São José dos Campos completed a questionnaire to evaluate the technical ease of use and provider acceptance. The obtained data were submitted to statistical analysis, evaluating technical ease and acceptance by operators.ResultsThe results were analyzed using descriptive and inferential statistics using the Jamovi 2.2.5 software. From the responses, the frequency was obtained for each question in the questionnaire, then the weighted mean was calculated, average rating and percentage. With the results of these analyses it was possible to measure the level of satisfaction of the participants in relation to the use of the device.ConclusionIt was concluded that most students have difficulty using the conventional Fox plane and that the accessory facilitated the process of determining the superior orientation plane, and its ease of use.