bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations of bisphenol A exposure with metabolic syndrome and its components: A systematic review and meta‐analysis
Authors: Xiao Tianli , Huang Zehua , Zheng Chanjuan , Quach Binh , Zhu Yulian , Li Feifei , Liang Wei , Baker Julien , Reichetzeder Christoph , Hocher Berthold , Yang Yide 
Published: March 2024

SummaryMounting evidence shows that bisphenol A (BPA) is associated with metabolic risk factors. The aim of this study was to review related epidemiologic studies and conduct a meta‐analysis to quantitatively estimate the association between BPA and metabolic syndrome. Four electronic databases were systematically searched to identify suitable articles. A total of 47 published studies were finally included. Two studies involved metabolic syndrome. Of the 17, 17, 14, and 13 studies on the relationship between BPA with abdominal obesity, blood pressure, fasting plasma glucose, and dyslipidemia, 10, 6, 3, and 4 studies were included in the meta‐analysis, respectively. The results showed that the risk of abdominal obesity increased with the increase of BPA exposure, especially in the group with higher BPA exposure levels (Quartile 2 vs. Quartile 1, pooled OR = 1.16, 95%CI: 1.01, 1.33; Q3 vs. Q1, pooled OR = 1.31, 95%CI: 1.13, 1.51; Q4 vs. Q1, pooled OR = 1.40, 95%CI: 1.21, 1.61). However, there was no significant correlation between BPA exposure and metabolic syndrome components including hypertension, abnormal fasting plasma glucose, and dyslipidemia. The present study found that BPA exposure is significantly associated with a higher risk of abdominal obesity. However, the relationship between BPA with metabolic syndrome and its other components needs further longitudinal studies to verify.
The New Double‐row Bankart Repair Recovered Shoulder Stability without Excessive Motion Limitation: A Case–Control Study with Single‐row Bankart Repair
Authors: Cheng Xu , Wang Hangle , Jiang Yanfang , Shao Zhenxing , Cui Guoqing 
Published: March 2024

ObjectivesBankart lesion is one of the most common lesions of the glenohumeral joint. Several double‐row suture methods were reported for Bankart repair, which could provide more stability, yet more motion limitation and complications. Therefore, we introduced a new double‐row Bankart repair technique, key point double‐row suture which used one anchor in the medial line. The purpose of this article is to investigate the clinical outcomes of this new method and to compare it with single‐row suture.MethodsSeventy‐eight patients receiving key point double‐row suture or single‐row suture from October 2010 to June 2014 were collected retrospectively. The basic information including gender, age, dominant arm, and number of episodes of instability was collected. Before surgery, the glenoid bone loss was measured from the CT scan. The visual analogue scale, American shoulder and elbow surgeons, the University of California at Los Angeles shoulder scale, and subjective shoulder value were valued before surgery and at the last follow‐up.ResultsForty‐four patients (24 patients receiving single‐row suture and 20 patients receiving key point double‐row suture) were followed up successfully. The follow‐up period was 9.2 ± 1.1 years (range, 7.8–11.4 years). At the last follow‐up, no significant differences were detected for any of the clinical scores. The recurrence rate was 12.5% for the single‐row group and 10% for the double‐row group, respectively (p = 0.795) 14 patients (31.8%) in the single‐row group and nine patients (26.5%) in the double‐row group were tested for active range of motion. A statistically significant difference was found only for the internal rotation at 90° abduction (48.9° for single‐row and 76.7° for key point double‐row, p = 0.033).ConclusionThe key point double‐row sutures for Bankart lesions could achieve similar long‐term outcomes compared with single‐row suture, and one medial anchor did not result in a limited range of motion. The low recurrence rate and previous biomechanical results also indicate the key point double‐row suture is a reliable method.
Permanent junctional reciprocating tachycardia due to an atypical retrograde slow conducting decremental left posterolateral accessory pathway and tachycardia‐induced cardiomyopathy in a pregnant adolescent
Authors: Kohli Utkarsh , Hassan Sohail , Mercer Christopher , Rhodes Larry 
Published: March 2024

AbstractPermanent junctional reciprocating tachycardia (PJRT) is a rare form of supraventricular tachycardia (SVT) due to a retrograde slow conducting decremental accessory pathway (AP) which is often incessant and can lead to tachycardia‐induced cardiomyopathy (TIC). We report the challenging clinical course of a pregnant adolescent with PJRT due to an atypical retrograde slow conducting decremental left posterolateral AP. Pregnancy is known to exacerbate supraventricular arrhythmias and can lead to adverse maternal and fetal outcomes. To the best of our knowledge, there are no prior reports on the clinical course of rare incessant and difficult‐to‐treat arrhythmias such as PJRT in a pregnant adolescent patient.
Cardiac sarcoidosis with extensive and heterogeneous left ventricular FDG uptake in absence of guidelines indication for an implantable defibrillator: Ventricular tachycardia precipitated by immunosuppressive therapy, should we have done differently?
Authors: Voisine Emile , Lemay Sylvain , Beaudoin Jonathan , Jacob Philippe , Philippon François , Marchand Laurie , Vallée‐Marcotte Bastien , Bernier Florence , Laliberté Claudine , Fortin Sophie , Komlosy Marie‐Ève , Birnie David H. , Sénéchal Mario 
Published: March 2024

AbstractA 40‐year‐old man, newly diagnosed with cardiac sarcoidosis (CS) presented with symptomatic ventricular tachycardia three days after starting steroid‐based immunosuppressive therapy (IT). There was no clear guideline indication for implantable cardioverter‐defibrillator (ICD) before the initiation of IT. Shortly after ICD implantation and the initiation of anti‐arrhythmic drugs, recurring ventricular arrhythmias required titration of the anti‐arrhythmic drug therapy. One‐year follow‐up assessment showed no significant arrhythmias and complete PET scan FDG uptake suppression. This case, along with recent publications, suggests transient pro‐arrhythmic effects of steroids in patients with CS, which are not appropriately addressed in the current guidelines. We believe ICD implantation should be considered in clinically manifest CS before initiating IT, particularly in cases with heterogeneous and/or extensive FDG uptake on PET scans.
Oversharing: The downside of data sharing in local government
Authors: Caldarulo Mattia , Olsen Jared , Feeney Mary K. 
Published: March 2024

AbstractHealth crises, climate change, and technological hazards pose serious managerial and equity challenges for local governments. To effectively navigate the uncertainties and complexity, municipalities are increasingly collaborating with one another and sharing data and information to improve decision‐making. While data sharing fosters effectiveness in responding to threats, it also entails risks. One major concern is that local government managers often lack the knowledge and technical skills required for safe and effective data sharing, exposing municipalities to cyberthreats. Drawing on data sharing and cybersecurity scholarship, we investigate whether increased data sharing among local governments makes cities more or less vulnerable to cyberincidents. We test our hypotheses using data from two national surveys of U.S. local government managers conducted in 2016 and 2018. Our findings contribute to the literature on technology and risk in government by informing both public managers and researchers about the potential threats associated with data sharing.
Benralizumab in children with severe eosinophilic asthma: Pharmacokinetics and long‐term safety (TATE study)
Authors: Wedner H. James , Fujisawa Takao , Guilbert Theresa W. , Ikeda Masanori , Mehta Vinay , Tam Jonathan S. , Lukka Pradeep B. , Asimus Sara , Durżyński Tomasz , Johnston James , White Wendy I. , Shah Mihir , Werkström Viktoria , Jison Maria L. ,   all TATE investigators
Published: March 2024

AbstractBackgroundBenralizumab is an anti‐interleukin‐5 receptor α monoclonal antibody approved as an add‐on maintenance treatment for patients with uncontrolled severe asthma. Prior Phase 3 studies have evaluated benralizumab in patients aged ≥12 years with severe uncontrolled asthma. The TATE study evaluated the pharmacokinetics (PK), pharmacodynamics (PD), and safety of benralizumab treatment in children.MethodsTATE was an open‐label, Phase 3 study of benralizumab in children aged 6–11 years from the United States and Japan (plus participants aged 12–14 years from Japan) with severe eosinophilic asthma. Participants received benralizumab 10/30 mg according to weight (<35/≥35 kg). Primary endpoints included maximum serum concentration (Cmax), clearance, half‐life (t1/2), and blood eosinophil count. Clearance and t1/2 were derived from a population PK (popPK) analysis. Safety and tolerability were also assessed.ResultsTwenty‐eight children aged 6–11 years were included, with an additional two participants from Japan aged 12–14 years also included in the popPK analysis. Mean Cmax was 1901.2 and 3118.7 ng/mL in the 10 mg/<35 kg and 30 mg/≥35 kg groups, respectively. Clearance was 0.257, and mean t1/2 was 14.5 days. Near‐complete depletion of blood eosinophils was shown across dose/weight groups. Exploratory efficacy analyses found numerical improvements in mean FEV1, mean ACQ‐IA, patient/clinician global impression of change, and exacerbation rates. Adverse events occurred in 22/28 (78.6%) of participants; none led to discontinuation/death.ConclusionPK, PD, and safety data support long‐term benralizumab in children with severe eosinophilic asthma, and were similar to findings in adolescents and adults.Trial RegistrationClinicalTrials.gov‐ID: NCT04305405.
The interplay of short‐term mesophyll and stomatal conductance responses under variable environmental conditions
Authors: Márquez Diego A. , Busch Florian A. 
Published: March 2024

AbstractUnderstanding the short‐term responses of mesophyll conductance (gm) and stomatal conductance (gsc) to environmental changes remains a challenging yet central aspect of plant physiology. This review synthesises our current knowledge of these short‐term responses, which underpin CO2diffusion within leaves. Recent methodological advances in measuringgmusing online isotopic discrimination and chlorophyll fluorescence have improved our confidence in detecting short‐termgmresponses, but results need to be carefully evaluated. Environmental factors like vapour pressure deficit and CO2concentration indirectly impactgmthroughgscchanges, highlighting some of the complex interactions between the two parameters. Evidence suggests that short‐term responses ofgmare not, or at least not fully, mechanistically linked to changes ingsc, cautioning against usinggscas a reliable proxy forgm. The overarching challenge lies in unravelling the mechanistic basis of short‐termgmresponses, which will contribute to the development of accurate models bridging laboratory insights with broader ecological implications. Addressing these gaps in understanding is crucial for refining predictions ofgmbehaviour under changing environmental conditions.
Glycoprotein nonmetastatic melanoma protein B impacts the malignant potential of bladder cancer cells through its hem‐immunoreceptor tyrosine‐based activation motif
Authors: Kimura Tomokazu , Okita Yukari , Nagumo Yoshiyuki , Chin Jas Min , Fikry Muhammad Ali , Shiga Masanobu , Kandori Shuya , Kawahara Takashi , Suzuki Hiroyuki , Nishiyama Hiroyuki , Kato Mitsuyasu 
Published: March 2024

AbstractBladder cancer is one of the most common cancers among men worldwide. Although multiple genomic mutations and epigenetic alterations have been identified, an efficacious molecularly targeted therapy has yet to be established. Therefore, a novel approach is anticipated. Glycoprotein nonmetastatic melanoma protein B (GPNMB) is a type I transmembrane glycoprotein that is highly expressed in various cancers. In this study, we evaluated bladder cancer patient samples and found that GPNMB protein abundance is associated with high‐grade tumors, and both univariate and multivariate analyses showed that GPNMB is a prognostic factor. Furthermore, the prognosis of patients with high GPNMB levels was significantly poorer in those with nonmuscle invasive bladder cancer (NMIBC) than in those with muscle invasive bladder cancer (MIBC). We then demonstrated that knockdown of GPNMB in MIBC cell lines with high GPNMB inhibits cellular migration and invasion, whereas overexpression of GPNMB further enhances cellular migration and invasion in MIBC cell lines with originally low GPNMB. Therefore, we propose that GPNMB is one of multiple driver molecules in the acquisition of cellular migratory and invasive potential in bladder cancers. Moreover, we revealed that the tyrosine residue in the hemi‐immunoreceptor tyrosine‐based activation motif (hemITAM) is required for GPNMB‐induced cellular motility.
Carcinoma showing thymus‐like elements (CASTLE) with amyloid deposition in the parotid gland
Authors: Hamada Mei , Miyama Yu , Matsumura Satoko , Shintani‐Domoto Yukako , Urano Makoto , Yasuda Masanori 
Published: March 2024

AbstractCarcinoma showing thymus‐like elements (CASTLE) is a rare tumor that commonly occurs in the thyroid gland. Extrathyroidal CASTLE is rarer, and only 11 cases of CASTLE of major salivary glands have been reported to date. We report the first case of amyloid deposition in parotid CASTLE. A 63‐year‐old man presented with a slowly growing mass in the left parotid region. Computed tomography revealed an approximately 28 × 23 mm mass lesion in the left parotid gland, and squamous cell carcinoma was suspected on biopsy. The patient underwent a parotidectomy with neck dissection. Morphologically, the tumor cells were squamoid and formed nests with lymphoid infiltration. Immunohistochemically, the tumor cells exhibited immunoreactivity for CD5, CD117/c‐kit and Bcl‐2, p40, and CK5 but not for p16. We diagnosed the tumor as parotid CASTLE. Amyloid deposition was also observed in the primary tumor and metastatic lymph node lesions, which were immunoreactive for cytokeratin 5. Tumor cytokeratin‐derived amyloid deposition may be one of characteristics of parotid CASTLE.
Differential photosynthetic plasticity of Amazonian tree species in response to light environments
Authors: Nina Junior A. d. R. , Maia J. M. F. , Martins S. V. C. , dos Santos Nina N. V. , da Costa K. C. P. , de Carvalho J. C. , Schramm Mielke M. , Nunes‐Nesi A. , Araújo W. L. , de Carvalho Gonçalves J. F. 
Published: March 2024

ABSTRACT

To investigate how and to what extent there are differences in the photosynthetic plasticity of trees in response to different light environments, six species from three successional groups (late successional, mid‐successional, and pioneers) were exposed to three different light environments [deep shade – DS (5% full sunlight – FS), moderate shade – MS (35% FS) and full sunlight – FS].

Maximum net photosynthesis (Amax), leaf N partitioning, stomatal, mesophile, and biochemical limitations (SL, ML, and BL, respectively), carboxylation velocity (Vcmax), and electron transport (Jmax) rates, and the state of photosynthetic induction (IS) were evaluated.

Higher values of Amax, Vcmax, and Jmax in FS were observed for pioneer species, which invested the largest amount of leaf N in Rubisco. The lower IS for pioneer species reveals its reduced ability to take advantage of sunflecks. In general, the main photosynthetic limitations are diffusive, with SL and ML having equal importance under FS, and ML decreasing along with irradiance. The leaf traits, which are more determinant of the photosynthetic process, respond independently in relation to the successional group, especially with low light availability.

An effective partitioning of leaf N between photosynthetic and structural components played a crucial role in the acclimation process and determined the increase or decrease of photosynthesis in response to the light conditions.
No safe haven: Loss of avirulence in the plant pathogen Leptosphaeria maculans by DNA duplication and repeat‐induced point mutation
Authors: Idnurm Alexander , McCallum Alec J. , Van de Wouw Angela P. 
Published: March 2024

AbstractMicrobes can overcome the ability of plant resistance genes to confer protection against disease by mutating their corresponding avirulence genes. The fungus Leptosphaeria maculans causes blackleg disease on canola crops and subverts Brassica napus resistance genes through several DNA mutation mechanisms. One of these is repeat‐induced point (RIP) mutation, which can ‘leak’ into the avirulence genes from the adjacent repetitive sequences that the mutation process is targeting. Here, we identified populations of L. maculans in Australia that have extensive RIP mutations in the avirulence gene AvrLm2 and show that this has been triggered by a duplication of the gene and surrounding DNA that includes the distant (>55 kb in total) AvrLm6 gene. This finding provides another mechanism of mutation by which pathogens can overcome host resistance, and more broadly contributes to understanding the complex balance between gene duplication and genome defence.
Estimating the frequency of virulence against an Stb gene in Zymoseptoria tritici populations by bulk phenotyping on checkerboard microcanopies of wheat near‐isogenic lines
Authors: Suffert Frédéric , Le Prieur Stéphanie , Gélisse Sandrine , Dzialo Emmie , Saintenac Cyrille , Marcel Thierry C. 
Published: March 2024

AbstractMonitoring virulent strains within pathogen populations is crucial to improve host resistance deployment strategies. Such monitoring increasingly involves field pathogenomics studies of molecular polymorphisms in pathogen genomes based on high‐throughput screening technologies. However, it is not always straightforward to predict virulence phenotypes from these polymorphisms, and in planta phenotyping remains necessary. We developed a method for ‘bulk phenotyping on checkerboard microcanopies of wheat near‐isogenic lines’ (BPC) for estimating the frequency of virulence against a resistance gene in mixed populations of the fungal pathogen Zymoseptoria tritici, the causal agent of Septoria tritici blotch (STB) in wheat, without the need for strain‐by‐strain pathogen phenotyping. Our method involves the uniform inoculation of a microcanopy of two wheat lines—one with the target resistance gene and the other without it—with a multistrain mixture of isolates representative of the population to be characterized, followed by the differential quantification of infection points (lesions). Using Stb16q, a wheat resistance gene that has recently broken down in Europe, we found a robust correlation between the ratio of the mean number of lesions on each wheat line and the frequency of virulent strains in the inoculum. Using pairs of virulent and avirulent strains, as well as synthetic populations consisting of 10 virulent strains and 10 avirulent strains mixed in different proportions, we validated the principle of the method and established standard curves at virulence frequencies close to those observed in natural conditions. We discuss the potential of this method for virulence monitoring in combination with molecular methods.
Metabolome and Transcriptome Reveal Chlorophyll, Carotenoid, and Anthocyanin Jointly Regulate the Color Formation of Triadica sebifera
Authors: Liu Qing , Wang Leijia , He Lina , Lu Yongkang , Wang Lin , Fu Songling , Luo Xumei , Zhang Yanping 
Published: March 2024

AbstractThe Chinese tallow tree (Triadica sebifera) is an economically important plant on account of its ornamental value and oil‐producing seeds. Leaf colour is a key characteristic of T. sebifera, with yellow‐, red‐ and purple‐leaved varieties providing visually impressive displays during autumn. In this study, we performed metabolomic and transcriptomic analyses to gain a better understanding of the mechanisms underlying leaf colour development in purple‐leaved T. sebifera at three stages during the autumnal colour transition, namely, green, hemi‐purple, and purple leaves. We accordingly detected 370 flavonoid metabolites and 10 anthocyanins, among the latter of which, cyanidin‐3‐xyloside and peonidin‐3‐O‐glucoside were identified as the predominant compounds in hemi‐purple and purple leaves. Transcriptomic analysis revealed that structural genes associated with the anthocyanin biosynthetic pathway, chlorophyll synthesis pathway and carotenoid synthesis pathway were significantly differential expressed at the three assessed colour stages. Additionally, transcription factors associated with the MYB‐bHLH‐WD40 complex, including 22 R2R3‐MYBs, 79 bHLHs and 44 WD40 genes, were identified as candidate regulators of the anthocyanin biosynthetic pathway. Moreover, on the basis of the identified differentially accumulated anthocyanins and key genes, we generated genetic and metabolic regulatory networks for anthocyanin biosynthesis in T. sebifera. These findings provide comprehensive information on the leaf transcriptome and three pigments of T. sebifera, thereby shedding new light on the mechanisms underlying the autumnal colouring of the leaves of this tree.
A Critical Review of Conventional and Modern Approaches to Develop Herbicide‐Resistance in Rice
Authors: Sang Shifei , Wang Yanan , Yao Guoqin , Ma Tengyun , Sun Xiaohan , Zhang Yijing , Su Nan , Tan Xiaoyu , Abbas Hafiz Muhammad Khalid , Ji Shengdong , Zaman Qamar U. 
Published: March 2024

AbstractTogether with rice, weeds strive for nutrients and space in farmland, resulting in reduced rice yield and quality. Planting herbicide‐resistant rice varieties is one of the effective ways to control weeds. In recent years, a series of breakthroughs have been made to generate herbicide‐resistant germplasm, especially the emergence of biotechnological tools such as gene editing, which provides an inherent advantage for the knock‐out or knock‐in of the desired genes. In order to develop herbicide‐resistant rice germplasm resources, gene manipulation has been conducted to enhance the herbicide tolerance of rice varieties through the utilization of techniques such as physical and chemical mutagenesis, as well as genome editing. Based on the current research and persisting problems in rice paddy fields, research on the generation of herbicide‐resistant rice still needs to explore genetic mechanisms, stacking multiple resistant genes in a single genotype, and transgene‐free genome editing using the CRISPR system. Current rapidly developing gene editing technologies can be used to mutate herbicide target genes, enabling targeted genes to maintain their biological functions, and reducing the binding ability of target gene encoded proteins to corresponding herbicides, ultimately resulting in herbicide‐resistant crops. In this review article, we have summarized the utilization of conventional and modern approaches to develop herbicide‐resistant cultivars in rice as an effective strategy for weed control in paddy fields, and discussed the technology and research directions for creating herbicide‐resistant rice in the future.