bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hydration Therapy to Improve Amniotic Fluid Index and its Association with Improved Obstetric Outcome in a Teaching Hospital of Eastern India
Authors: Biswas Jhuma , Mondal Swarnakamal , Dasgupta Shyamal , Datta Mousumi , Khatun Nasima , Jyothi Lakavath 
Published: March 2024

Introduction:
Oligohydramnios is associated with fetal complications and a higher incidence of maternal operative morbidity. A study was planned to determine the effect of hydration therapy in the correction of oligohydramnios in pregnancy and to assess if improvement in amniotic fluid index (AFI) is associated with better obstetric outcomes.

Materials and Methods:
Analytical study with a prospective design, conducted over 1 year from July 2020 to December 2021. Pregnant women in their third trimester with singleton pregnancy and intact membranes, diagnosed to have oligohydramnios were the participants. All women undertook oral rehydration therapy. The proportion of women achieving posthydration cutoff values of AFI and single deepest vertical pocket, was recorded by abdominal ultrasound examination at 24, 48, and 72 h. Adequacy of hydration was assessed by urinary specific gravity, before and after hydration therapy.

Results:
There were 120 participants. The mean age of the participants was 25.6 years (standard deviation = 5.7). Majority were multigravida. About 60%–80% of women improved with hydration therapy and the proportion of women showing improvement increased with time. Women with uncorrected AFI (<5 cm) at 24 and 48 h had significantly higher odds of preterm delivery, cesarean delivery, low-birth-weight baby, baby having 5 min Apgar score < 6, higher likelihood of Sick Newborn Care Unit admission and neonatal death.

Conclusion:
Maternal hydration therapy can be of value to improve the fetomaternal outcome in pregnancies with oligohydramnios by preventing preterm termination and reducing cesarean deliveries with good neonatal outcomes. Such simple intervention can be home based and assures universal health coverage.
Evaluation of the Efficacy of Tranexamic Acid in Control of Bleeding in Total Knee Replacement
Authors: Satpathy Goutam Kumar , Swain Sabyasachi , Gouri L. V. , Nanda Debi Prasad 
Published: March 2024

Introduction:
Among the various strategies for in routine total knee replacement (TKR), tranexamic acid (TA) has always been a safer and affordable method. Surgeons have used it in intravenous, intraarticular or in a combined manner to reduce blood loss because it is easily available and has an easy dosing regimen. We aim to find out its efficacy and associated complication when used intravenously.

Materials and Methods:
This study was done in our institute among 27 cases who was operated for primary TKR. They were distributed into two groups based on the use of TA. Hemodynamic parameters such as blood loss, reduction in hemoglobin (Hb), and blood transfusion were assessed. Student's t-test and ANOVA were utilized for tests of significance.

Results:
Out of 27 patients, 17 (62.9%) were female and in the age group of 51–60 years. Most 22 (81.5%) had osteoarthritis. The difference in blood loss across various pathologies and comorbidities was statistically insignificant. Average blood loss was 266.2 ml ± 64 ml (Range = 150–406 ml) per TKR in the 1st group. In 2nd, it was 667.5 ± 111.5 ml (Range = 414–860 ml) (P < 0.001). Mean Hb loss was 0.78 ± 0.275 g/dl (Range = 0.1–1.2 g/dl) in Group A. It was statistically significant comparing to Group B where it was 1.86 ± 0.55 g/dl (Range = 1.5–3.7 g/dl). Tourniquet used though decreased blood loss, it was not statistically significant.

Conclusion:
TA used in intravenously is very effective in decreasing the loss of blood and transfusion requirements in patients of primary TKR.
Postoperative Herpes Viral Infections in Neurosurgery – An Experience and Arguments for and against the Plausible Hypotheses
Authors: Kumar Sanjeev , Sahana Debabrata , Rathore Lavlesh , Jain Amit , Borde Praveen , Tawari Manish , Sahu Rajiv 
Published: March 2024

Background:
The literature contains several reports of herpes recrudescence after neurosurgery. We analyze our experience by vindicating or refuting the existing plausible hypotheses.

Material and Methods:
This is a retrospective review of all neurosurgical cases that developed postoperative herpes infection between January 2016 and June 2020.

Results:
Six patients developed herpes infection after vestibular schwannoma (VS) surgery. Other neurosurgical cases did not develop herpes infection. There were five females and one male, with a mean age of 44.1 years. Four out of six patients developed delayed facial palsy (DFP) and did not improve after antiviral treatment. Postoperative herpes infections were 0.2% among all operated patients, 3.07% among all cerebellopontine (CP) angle surgeries, and 5.6% among VS surgeries.

Conclusions:
To date, none of the plausible hypotheses satisfactorily addresses all aspects of viral recrudescence. The etiology may be multi-factorial, and in all cases of unexplained clinical deterioration, herpes infection needs consideration in the differential diagnosis.
Differential Protein Expression between the Motor and Sensory Fascicles in Rat Femoral Nerve Injury
Authors: Xianyu Meng , Zhenggang Bi , Jian Shang , Laijin Lu 
Published: March 2024

Background and Aims:
It is important to distinguish between motor and sensory fascicles of the peripheral nerves for nerve alignment in surgery. However, there are no biomarkers currently available for effective identification of motor or sensory fascicles. The objective of this study was to identify differentially expressed proteins between motor and sensory fascicles of rats in response to injury.

Settings and Design:
The study was carried out using a rat femoral nerve injury model.

Materials:
A proteomic analysis was performed to detect differential protein expression using samples of bilateral motor and sensory branches of intact and injured rat femoral nerves through fluorescent two-dimensional difference gel electrophoresis and matrix-assisted laser desorption ionization-time of flight mass spectrometry.

Statistical Analysis:
Chi-square tests and t-tests were performed for comparison between motor or sensory nerve groups.

Results:
The data identified six proteins that were differentially expressed between motor and sensory fascicles (>1.5-fold, P < 0.05), including apolipoprotein E, neurofilament light polypepticle, TEC kinase, serine protease inhibitor A3N, peroxiredoxin-2, and TPM1. The proteomic results were consistent with the mRNA expression levels of these genes as determined by quantitative reverse transcription polymerase chain reaction.

Conclusions:
Our study suggests that these proteins may play roles in nerve regeneration and repair. Importantly, apolipoprotein E and Serpina3n may serve as specific biomarkers for distinguishing motor and sensory fascicles of the peripheral nerves for nerve alignment in surgery.
Myositis in H1N1 Infection Compounds to Myasthenic Crisis
Authors: Kalita Jayantee , Chaudhary Sarvesh K , Pandey Prakash C , Singh Varun K , Misra Usha K 
Published: March 2024

Abstract
Infection is an important trigger of myasthenic crisis (MC), and those infections manifest with pneumonia and muscle involvement may result in more frequent MC. We report two myasthenia gravis (MG) patients with H1N1 infection, and highlight the reasons for deterioration. Two patients with MG had H1N1 infection. The diagnosis of MG was confirmed by neostigmine, repetitive nerve stimulation, and anti-acetylcholine receptor antibody tests. H1N1 was confirmed by nucleic acid detection study, and myositis by creatinine kinase. The patient with pneumonia and myositis had MC needing mechanical ventilation for 10 days, and the other patient without myositis did not have MC. They were treated with oseltamivir 75 mg twice daily for 5 days, and the patients with MC received ceftriaxone intravenously. Both the patients were on prednisolone and azathioprine, and none received prior H1N1 vaccination. The lady with MC with myositis was discharged on day 27 in wheelchair bound state, and the other one patient without myositis or MC was discharged on 6th day with full recovery. These patients highlight the need for evaluation for myositis along with pneumonia in the MG patients with H1N1 infection. Vaccination in MG patients on immunosuppression may be useful.
Cerebrotendinous Xanthomatosis, a Treatable Disorder Often Missed: Case Series of Three Patients Confirmed by Genetic Testing
Authors: Yaqoob Arjimand , Dar Waseem R. , Raina Adnan , Khuja Zubair , Chandra Amit , Bukhari Immia , Ganie Hilal , Wani Maqbool , Asimi Ravouf 
Published: March 2024

Abstract
Cerebrotendinous xanthomatosis (CTX) is a treatable autosomal recessive disorder with varied clinical manifestations and age of onset and is often diagnosed late. We report three cases of CTX who presented at our center with clinical features of frequent diarrhea, early cataracts, xanthomas, cognitive decline, ataxia, neuropathy, and other manifestations of CTX. Magnetic resonance imaging (MRI) brain in all three patients revealed abnormalities consistent with CTX. Diagnosis was confirmed by next-generation sequencing. Chenodeoxycholic acid (CDCA) is recommended as the drug of choice, as it can halt the disease progression and reverse some of the symptoms. In addition to late diagnosis, nonavailability of CDCA in our part of world adds to the problem of management of such patients; therefore, they are often started on alternative therapies, which are less effective.
Melatonin Levels in Children with Migraine
Authors: Aydın Tahir , Ayça Senem , Yurdakul Kamer , Elevli Murat 
Published: March 2024

Background:
Migraine is the most common primary headache in children. Neuromediators and deterioration in circadian rhythm and sleep disorders can play a role in the etiology of migraines.

Aim:
To determine the serum melatonin levels of children with migraine and the relationship between melatonin and childhood migraine.

Materials and Methods:
Thirty-five children aged between 10 and 18 years with migraine as the case group and 35 healthy children of similar age and sex as the control group were included in the study. Venous blood samples were taken at 09.00 AM and melatonin analysis was performed using enzyme-linked immunosorbent assay (ELISA).

Results:
The mean serum melatonin levels of the case group and control group were found to be 300.1 ± 67.3 pg/mL and 314.9 ± 64.0 pg/mL, respectively. There was no statistically significant difference between the groups (P = 0.351). Comparison of the melatonin levels in the case group according to the clinical characteristics was not significantly different.

Conclusion:
An association between sleep and migraine is predictable, but its pathophysiology is not yet known. Etiological studies continue and the relationship between melatonin and migraine remains unclear.
Predicted survival of patients with human immunodeficiency virus-associated non-Hodgkin’s lymphoma based on clinical and imaging factors: A multicenter retrospective study
Authors: Ren Meiji , Jiang Dongmei , Pan Ziang , Shi Yuxin , Liu Jinxin , Wang Xing , Lu Zhiyan , Gong Xiaoming , Hu Tianli , Li Li , Li Wenfei , Li Xueqin , Xia Shuang , Li Hongjun 
Published: March 2024

BACKGROUND:
Non-Hodgkin’s lymphoma (NHL) has a poor prognosis and serious risk of mortality. Furthermore, the clinical and imaging characteristics differ between human immunodeficiency virus (HIV)-positive and HIV-negative NHL. We aimed to create a nomogram based on imaging, clinical, and laboratory indicators to predict the mortality risk of patients with HIV-positive NHL.

MATERIALS AND METHODS:
A total of 306 patients were enrolled. The training cohort comprised 194 patients with HIV-positive NHL treated at four Chinese medical centers between April 2012 and October 2020. A series of statistical methods were used to screen potential predictive factors for inclusion in a prognostic nomogram. The performance of the nomogram was assessed by internal validation, external validation, and clinical utility. The independent external verification cohort comprised 112 patients treated between January 2013 and November 2020.

RESULTS:
After investigating 39 potentially predictive factors, a nomogram containing eight factors (three imaging factors, four clinical factors, and one HIV-infection special factor) was developed. Internal and external validation revealed good discrimination (concordance index: 0.837 vs. 0.817; 95% confidence interval, 0.826–0.848 vs. 0.798–0.836) and excellent calibration. Regarding the clinical utility, our nomogram was more accurate in predicting survival than the International Prognostic Index (area under the curve, 0.9217 vs. 0.8150; sensitivity, 0.85 vs. 0.67; and specificity, 0.89 vs. 0.87). The nomogram identified low-risk, intermediate-risk, and high-risk groups with 1-year survival rates of 95%, 59%, and 2%, respectively.

CONCLUSION:
The nomogram model based on imaging, clinical, and laboratory indicators may be useful in predicting the treatment efficacy and long-term mortality risk of patients with HIV-positive NHL. This may provide a new scientific basis for clinical decision-making.
Lamellar surgeries with SMILE-derived lenticules
Authors: Ganesh Sri , Brar Sheetal , Chopra Riya 
Published: March 2024

Abstract:

PURPOSE:
Lamellar surgeries with SMILE lenticules are an evolving field of refractive surgery. This chapter intends to discuss the reported clinical results of using SMILE derived lenticules in terms of feasibility, safety and predictability; or the potential management of hyperopia, keratoconus, SMILE ectasia and presbyopia.

MATERIALS AND METHODS:
Donor SMILE lenticules were prepared under microscope tocreate doughnut shaped lenticules. For hyperopia, this tissue was then inserted into afemtosecond laser enabled pocket created using VisuMax FS Laser at a depth of 160µm. For ectasia induced by keratoconus and post refractive procedure (SMILE), 0.23% riboflavin dye was instilled into the interface and then lenticule was inserted followed by exposure to UV-A radiation with total energy of 6.3 J.

RESULTS:
Spherical equivalent (S.E.) of within ± 0.5 D was observed in 50% (n=21) eyes and within 1 D was seen in 71% eyes treated for hyperopia. A significant increase in the K mean anterior, central corneal thickness, Q-value and corneal aberrations was seen 2 weeks post-op. Clinical improvement in terms of S.E. and uncorrected distance visual acuity in eyes treated for ectasia after keratoconus and post refractive procedure (SMILE) was seen.

CONCLUSION:
With the ample availability of SMILE- derived lenticules, researchers are exploring the possibility of using this tissue for the treatment of various refractive and corneal conditions.
Cold and Hot Syndromes in Traditional Chinese Medicine: Insights from the Perspective of Immunometabolic Homeostasis
Authors: Chen Pan , Wang Bo-Yang , Zhang Peng , Li Shao 
Published: March 2024

Abstract
The core principle of diagnosis and treatment in traditional Chinese medicine (TCM) is the identification of different syndromes. Cold and hot syndromes are important elements in TCM theory. Identifying the biological basis of cold and hot syndromes in TCM will help elucidate TCM theories scientifically, thus promoting precise treatment in TCM. Although the biological basis of cold/hot syndromes in TCM remains poorly understood, growing evidence suggests that immunometabolic interactions play an important role in balancing cold and hot syndromes. Immunometabolism involves complex interactions between the immune and metabolic systems. Multilevel mechanisms of interaction between the immune and metabolic systems may underlie many inflammatory diseases and offer substantial therapeutic promise. Therefore, dissecting the relationship between immunometabolism and the biological network of cold/hot syndromes has become a priority. This article reviews the progress of cold/hot syndrome research from the perspective of immunometabolic homeostasis, thus further clarifying cold/hot syndromes in TCM.
Linear independence of series related to the Thue–Morse sequence along powers
Authors: Coons Michael , Tachiya Yohei 
Published: March 2024

AbstractThe Thue–Morse sequence
$\{t(n)\}_{n\geqslant 0}$
is the indicator function of the parity of the number of ones in the binary expansion of nonnegative integers n, where
$t(n)=1$
(resp.
$=0$
) if the binary expansion of n has an odd (resp. even) number of ones. In this paper, we generalize a recent result of E. Miyanohara by showing that, for a fixed Pisot or Salem number
$\beta>\sqrt {\varphi }=1.272019\ldots $
, the set of the numbers
$$\begin{align*}1,\quad \sum_{n\geqslant1}\frac{t(n)}{\beta^{n}},\quad \sum_{n\geqslant1}\frac{t(n^2)}{\beta^{n}},\quad \dots, \quad \sum_{n\geqslant1}\frac{t(n^k)}{\beta^{n}},\quad \dots \end{align*}$$
is linearly independent over the field
$\mathbb {Q}(\beta )$
, where
$\varphi :=(1+\sqrt {5})/2$
is the golden ratio. Our result yields that for any integer
$k\geqslant 1$
and for any
$a_1,a_2,\ldots ,a_k\in \mathbb {Q}(\beta )$
, not all zero, the sequence {
$a_1t(n)+a_2t(n^2)+\cdots +a_kt(n^k)\}_{n\geqslant 1}$
cannot be eventually periodic.
Robotic Drilling: A Review of Present Challenges
Authors: Cho Yun Hang , Sawyer Daniela , Burkinshaw Christopher , Scraggs Chris 
Published: March 2024

<div class="section abstract"><div class="htmlview paragraph">In numerous industries such as aerospace and energy, components must perform under significant extreme environments. This imposes stringent requirements on the accuracy with which these components are manufactured and assembled. One such example is the positional tolerance of drilled holes for close clearance applications, as seen in the “EN3201:2008 Aerospace Series – Holes for metric fasteners” standard. In such applications, the drilled holes must be accurate to within ±0.1 mm. Traditionally, this required the use of Computerised Numerical Control (CNC) systems to achieve such tight tolerances. However, with the increasing popularity of robotic arms in machining applications, as well as their relatively lower cost compared to CNC systems, it becomes necessary to assess the ability of robotic arms to achieve such tolerances. This review paper discusses the sources of errors in robotic arm drilling and reviews the current techniques for improving its accuracy. The main sources of errors in robotic arm drilling are related to the robot arm positioning, the drilling processes, and the dimensional accuracy/quality of the workpiece being drilled. This paper focuses on two of these aspects: the robotic arm positioning and the drilling error. Hardware correction systems using vision, encoder and/or a combination of lasers are considered alongside software-based methods such as machine learning. This can implicitly improve the accuracy of robotic arms without any additional hardware. In addition, spatial interpolation techniques such as Kriging are also discussed in the context of gathering calibration data over a grid of points. From this paper, the reader will gain an understanding of the state-of-the-art, future trends and the potential work required to use robotic arms for drilling high-accuracy holes in aerospace applications.</div></div>
KEMAMPUAN SISWA DALAM MEMAHAMI MATERI PESAWAT SEDERHANA DALAM PEMBELAJARAN IPA KELAS IX SMP NEGERI 4 SATU ATAP ENTIKONG
Authors: Noviyah Noviyah , Mustajab Amin , Minarti Veronica 
Published: March 2024

Kurangnya pemahaman peserta didik dalam materi pesawat sederhana yang dijelaskan dalam pembelajaran fisika. Peningkatan pemahaman isi pelajaran menuntut peserta didik banyak berlatih mengenai pemahaman materi, keberhasilan dalam pembelajaran biasanya diukur dari bagaimana peserta didik memahami materi yang dipelajari. Semakin banyak peserta didik yang dapat mencapai tingkat pemahaman materi, maka semakin tinggi keberhasilan dalam pembelajaran tersebut. Penelitian ini membahas tentang kemampuan peserta didik untuk memahami materi pesawat sederhana dalam pembelajaran ilmu pengetahuan alam (IPA). Rumusan masalah dalam penelitian ini adalah mengetahui bagaimana cara agar peserta didik dapat memahami materi pesawat sederhana dikelas IX SMP Negeri 4 Satu Atap Entikong. Penelitian ini bertujuan untuk mengetahui tingkat kemampuan siswa dalam memahami materi pesawat sederhana dalam pembelajaran IPA di kelas IX SMP Negeri 4 Satu Atap Entikong. Jenis penelitian yang digunakan adalah deskriptif dengan pendekatan kuantitatif. Penelitian ini dilakukan di SMP Negeri 4 Satu Atap Entikong dengan subjek penelitian berjumlah 15 peserta didik. Instrumen yang digunakan adalah tes berbentuk soal pilihan ganda, data yang diperoleh dari hasil tes kemudian dianalisis menggunakan tabel kategori kemampuan peserta didik, kemudian untuk menentukan persentase dengan menggunakan rumus persentase.
Pengaruh Intensitas Iklan Media Sosial Terhadap Perilaku Konsumtif Pada Mahasiswa
Authors: Ansar Ansyar 
Published: March 2024

Indonesia menempati urutan keempat sebagai pengguna internet aktif, aktivitas penggunaan internet tidak hanya digunakan untuk mencari informasi, tetapi juga untuk aktivitas berbelanja. data Asosiasi Penyelenggara Jasa Internet (APJII) tahun 2021-2022, mahasiswa mendapatkan posisi kedua tertinggi sebagai pengguna internet untuk aktivitas berbelanja Tujuan dari penelitian ini adalah mengetahui pengaruh intensitas iklan media sosial terhadap perilaku konsumtif pada mahasiswa. Metode penelitian yang digunakan metode Kuantitatif dan analisis data yang digunakan yaitu uji regresi linier sederhana. Subjek penelitian ini yaitu mahasiswa perguruan tinggi di Kalimantan Selatan dengan total sampel 202 subjek. Berdasarkan teknik sampel purposive sampling, hasil uji regresi linier sederhana, didapatkan bahwa nilai signifikansi sebesar 0,000, yang artinya intensitas iklan media sosial berpengaruh secara signifikan terhadap perilaku konsumtif pada mahasiswa.

Kata Kunci : Perilaku Konsumtif, Intensitas Iklan, Mahasiswa

Indonesia ranks fourth as an active internet user, the activity of using the internet is not only used to find information, but also for shopping activities. data from the Association of Internet Service Providers (APJII) for 2021-2022, students get the second highest position as internet users for shopping activities. The purpose of this research is to determine the effect of the intensity of social media advertising on consumer behavior in students. The research method used is quantitative and the data analysis used is a simple linear regression test. The subjects of this study were university students in South Kalimantan with a total sample of 202 subjects. Based on the purposive sampling technique, the results of a simple linear regression test, it was found that the significance value was 0.000, which means that the intensity of social media advertising has a significant effect on consumer behavior in students.

Keywords: Consumptive Behavior, Advertising Intensity, Students
Peningkatan Hasil Belajar Passing Atas dalam Pembelajaran Permainan Bola Voli Melalui Metode Kedinding dan Berpasangan
Authors: Lina Malinda  , Nugroho Agung S  , Dian Helaprahara  
Published: March 2024

Tujuan penelitian ini adalah untuk mengetahui peningkatan hasil belajar passing atas siswa dalam permainan bola voli. Metode yang digunakan penelitian ini adalah penelitian action reseach classroom yang dilaksanakan dua kali pertemuan dalam setiap siklusnya. Subjek penelitian hanya siswa kelas VIII MTs. Nurul Huda II Kec. Rubaru dengan jumlah 10 siswa. Hasil penelitian menunjukkan bahwa pada pembelajaran teknik passing atas bola voli dalam siklus pertama terdapat 20% siswa bisa melakukan passing atas dengan benar dengan nilai minimal 20 dan nilai maksimal 80. Pada siklus II passing atas siswa menjadi 90% dengan nilai minimal 60 dan maksimal 100. Sehingga kesimpulan penelitian ada peningkatan pada pembelajaran passing atas dalam pembelajaran bolavoli melalui metode kedinding dan berpasangan sebesar 70% dan tergolong klasifikasi tinggi.