bluuebunny/crossref_metadata_2025_split huggingface dataset:
Challenges and preventive strategies in pediatric drug hypersensitivity reactions: where do we stand?
Authors: Klain Angela , Galletta Francesca , Mori Francesca , Bettini Irene , Tomei Leonardo , Senatore Antonio Andrea , Manti Sara , Licari Amelia , Miraglia del Giudice Michele , Indolfi Cristiana 
Published: February 2025

Abstract
Drug hypersensitivity reactions (DHRs) in pediatric patients present significant clinical challenges due to their potential for severe, life-threatening reactions such as anaphylaxis. Although less common than in adults, DHRs in children are more difficult to diagnose and manage due to limited pediatric-specific research. This study focuses on the role of premedication as a preventive strategy for DHRs, exploring its potential benefits and limitations. While approaches like H1-antihistamines combined with gradual drug dose escalation show promise for reducing mild histamine-mediated reactions, evidence regarding premedication’s effectiveness, particularly for non-IgE-mediated mechanisms, remains inconclusive. Rapid drug desensitization (RDD) protocols demonstrate high success rates in certain cases; however, there are no strong recommendations for or against premedication, and controlled studies documenting its real efficacy are lacking. Further research is crucial to establish clear guidelines and improve the safety and outcomes of pediatric drug allergy management.
Comparison of heroin and fentanyl use in US nationally representative surveys
Authors: Pytell Jarratt D. , Christine Paul J. , LeMasters Katherine , Rockhill Karilynn M. , Black Joshua C. , Dart Richard C. , Binswanger Ingrid A. 
Published: February 2025

Abstract

Background
Given the opioid overdose crisis, surveillance of evolving opioid use patterns is critical to the effective deployment of mitigation strategies. The National Survey on Drug Use and Health (NSDUH) provided the first annual US estimate of illicitly manufactured fentanyl (IMF) use in 2022. However, as a household survey, NSDUH may not capture the full extent of population heroin and IMF use. We compare estimates of past-year heroin and IMF use and correlates of use in NSDUH and the Survey of Non-Medical Use of Prescription Drugs (NMURx) survey which employ an alternate sampling strategy.

Methods
We conducted a cross-sectional analysis of the 2022 NSDUH and NMURx. NSDUH samples respondents using a probability-based approach targeting community-dwelling individuals, while NMURx samples respondents using an opt-in, online survey panel. US adults ages 18 years and older were included. The main outcomes were differences in the weighted percentage of population reporting past-year use of heroin, IMF, and either heroin or IMF between the surveys. Secondary outcomes were the patterns of association of past-year heroin or IMF use with comorbid substance use, treatment utilization, and demographic characteristics between the surveys. Data were analyzed March to June 2024.

Results
NSDUH (n = 47,100 respondents) had a lower proportion of respondents who identified as non-Hispanic White and graduated college, and a higher proportion with past week employment than NMURx (N = 59,041 respondents). Past-year use of heroin, IMF, and either heroin or IMF were lower in the NSDUH than the NMURx. NSDUH estimated 0.52% (95% CI: 0.40%, 0.69%) %) of the US population used either heroin or IMF in the past year compared to 1.05% (95% CI: 0.97%, 1.14 0) in NMURx. In regression models, stimulant and benzodiazepine use were consistently associated with increased heroin or IMF use across both surveys.

Conclusions and relevance
The estimated prevalence of heroin or IMF use was nearly 50% higher in the NMURx compared to NSDUH. These results highlight the importance of using complementary surveillance approaches to obtain accurate estimates of the prevalence and patterns of heroin or IMF use.
Food security and crises: evidence from the Western Balkans
Authors: Jámbor Attila , Varga Ágnes 
Published: February 2025

Abstract

Context
The world has experienced many global shocks in recent years, especially affecting vulnerable countries, people and groups. The analysis of recent impacts helps us to better understand how to build more sustainable agri-food systems.

Objectives
This paper aims to analyse the situation and main determinants of food security in the Western Balkans in light of the recent crises to ensure higher resilience for the future.

Methods
It follows a threefold approach. First, the food security situation in the different countries was analysed quantitatively using descriptive statistics of the main indicators on a time-series basis and the main determinants of food security. Second, the results of the semi-structured interviews with local experts were presented to understand the reasons for the changing patterns of food security. Third, results were validated during a hybrid workshop.

Results
Our findings suggest that food security and food supply were stable in most cases, while a large number of small farms, rural depopulation, climate change and harmonisation of food systems were cited as the main challenges. The COVID-19 pandemic did not appear to have a serious impacted on food security, although it has certainly accelerated the restructuring within the agri-food sectors. However, the war in Ukraine has had a greater impact, particularly in terms of high price inflation and rising prices for agricultural inputs.

Conclusions
This paper analysed the food security situation in the Western Balkans in the light of recent crises. Although the region has made good progress in reducing poverty and inequality in recent decades, the COVID-19 pandemic and the war in Ukraine appear to have stalled or, in some cases, even reversed this progress. This paper provides a number of policy recommendations based on the results to shape future policies of the region towards higher resilience.
Perceived teacher support and student engagement among higher education students – a systematic literature review
Authors: Prananto Kartika , Cahyadi Surya , Lubis Fitriani Yustikasari , Hinduan Zahrotur Rusyda 
Published: February 2025

Abstract

Background
Research on student engagement has garnered significant interest from educators and practitioners because of its direct impact on academic success and achievement. Engaged students tend to perform better academically and exhibit fewer undesirable study behaviors, thereby enhancing academic outcomes.

Objective
This systematic literature review consolidates research on the impact of perceived teacher support on student engagement in higher education. This study emphasizes the association between teacher support in improving students’ academic performance, motivation, and retention. Furthermore, the review explores key theoretical frameworks, such as self-determination theory and social cognitive theory, alongside methodological tools such as measurement instruments and statistical analyses. The goal is to equip psychologists and educational researchers with insights into the relevant frameworks, tools, and methods for advancing future studies within the context of higher education.

Methods
This study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) methodology. We conducted a comprehensive search for academic studies published in English within databases such as APA PsycNet, Scopus, ERIC, EBSCOHost, ProQuest, and PubMed to identify eligible studies published between 2014 and 2024.

Results
A review of 13 selected articles revealed that both students’ personal characteristics and school environment factors mediate and moderate the relationship between perceived teacher support and student engagement. The students’ personal characteristics factors include self-efficacy, the fulfillment of psychological needs, and motivation, whereas school environment factors involve the learning environment and the quality of teacher-student and peer relationships. Our findings show a lack of studies prior to 2020, with most research conducted in China and limited contributions from Malaysia and Vietnam. The reviewed articles predominantly used cross-sectional quantitative designs and self-report questionnaires, employing statistical methods like path analysis and structural equation modeling. Theoretical frameworks on student engagement mostly followed Fredricks et al.‘s model, while teacher support theories varied, with three main patterns identified: direct influence, mediation through basic psychological needs, and social cognitive perspectives. This review emphasizes the crucial role of teacher support in enhancing student engagement in higher education and urges further exploration in this under-researched area.

Conclusion
In conclusion, this review underscores the significant role of teacher support in enhancing student engagement in higher education. It highlights key theoretical frameworks and research methodologies, offering valuable insights for future studies aimed at advancing teacher support and student engagement in this context.
Distributions of heme B and its implications on Fe biogeochemistry in the eastern Indian Ocean and the western North Pacific Ocean
Authors: Isaji Yuta , Sugie Koji , Ishikawa Naoto F. , Ogawa Nanako O. , Matsumoto Kazuhiko , Yoshikawa Chisato , Obata Hajime , Honda Makio C. , Ohkouchi Naohiko 
Published: February 2025

Abstract
Heme B is an iron-coordinated porphyrin cofactor that facilitates essential biochemical reactions. As a major iron component in almost all life forms, the abundance of heme B in the ocean provides novel insights into iron biogeochemistry. In this study, we investigated the distribution of heme B in suspended particulate material collected from the surface mixed layer of the eastern Indian Ocean and the western North Pacific Ocean. Within the photic zone of the regions studied, particulate heme B concentrations ranged 1.24–8.39 pmol L−1and were positively correlated with particulate organic carbon and chlorophyll a concentrations, consistent with the biologically ubiquitous nature of heme B. Profiles of heme B normalized to particulate organic carbon (heme B/POC) and chlorophyll a (heme B/chl a) revealed a complex response of the microbial heme B pool to environmental factors. In the eastern Indian Ocean, heme B/POC increased in response to enhanced iron bioavailability. Notably, a sharp increase in heme B/POC, up to 3.04 µmol mol−1 in the Bay of Bengal, was attributed to the alleviation of iron stress due to substantial iron inputs from monsoonal aeolian dust and riverine sources. Conversely, heme B/POC as low as 0.88 µmol mol−1 in the South Indian Ocean was consistent with the previous incubation experiments indicating iron limitation. In the western North Pacific Ocean, relatively low heme B/POC values in both the iron-limited subarctic and nitrogen-limited subtropical regions highlighted the influence of factors beyond iron bioavailability. In the subarctic region, an elevation in dissolved iron concentrations due to seasonal deepening of the surface mixed layer was counterbalanced by greater iron investment in photosynthetic proteins to acclimate to low light intensities. On the other hand, microbial communities in the subtropical western North Pacific Ocean were less likely to have experienced iron stress. However, a reduction in the intracellular abundance of heme B-containing photosynthetic proteins and nitrate reductase under nitrogen-limited conditions may have resulted in heme B/POC values comparable to those observed in the iron-limited regions. Based on our particulate heme B measurements, we estimated the global particulate biogenic iron pool in the surface ocean, which showed consistency with model-simulated estimates. This study highlights the utility of heme B as a valuable parameter for understanding iron biogeochemistry, which is critical for elucidating the links between marine iron and carbon cycles.
Kinematic analysis and experimental verification of transforming planar linkage mechanism
Authors: Unde Jayant , Ito Yahiro , Colan Jacinto , Hasegawa Yasuhisa 
Published: February 2025

Abstract
This paper explores the kinematic characteristics of a novel transforming planar linkage mechanism characterized by a coiling and uncoiling motion pattern. Unlike traditional deployable structures that depend on scaling transformations, this mechanism utilizes a four-bar linkage system that rotates collectively to achieve the desired transformation with a single degree of freedom. The study provides a comprehensive analysis of the mechanism’s properties, highlighting its singularity points, trajectory variations, and transformation capabilities contingent on the fixed frame’s position. These properties are validated through simulations and experimental tests, supporting the analytical findings. Furthermore, a tendon-driven actuation method tailored for this mechanism is introduced and validated using a physical prototype. The results contribute significantly to understanding this innovative planar linkage mechanism, offering valuable insights for designing novel mechanical systems and applications.
One pot of Sonogashira coupling and oxidation of alcohol reactions by magnetic nanocatalyst in an ideal environment
Authors: Binandeh Mansour 
Published: February 2025

Abstract
Mainly in the new era, there is a need to accelerate chemical reactions, which is made possible by advanced nanocatalysts, whose magnetic nanocatalysts are highly efficient in controlling chemical reactions such as Sonogashira coupling and alcohol oxidation. Magnetic nanocatalysts are made of magnetite nanoparticles under the chemical co-precipitation method. Their structure was identified by analysis such as EDX (energy-dispersive X-ray) and XRD (X-ray diffraction). The Sonogashira carbon–carbon coupling reaction was performed twice consecutively, and the product efficiency was more than 97%. Oxidation of alcohols to produce aldehyde products is up to 99%. The structure of the magnetic nanocomposite was analyzed after several reuses, and the results showed that it was unchanged, and its performance, structure, and magnetic properties were fully preserved. The reaction conditions are at the lowest possible temperature, harmless solvents, and the highest efficiency percentage, which creates green conditions. The products obtained from the Sonogashira double coupling reaction have two triple bonds. Also, the products with the oxidation of alcohols, which are used as the main precursors in the chemical and medical industries for chemical and pharmaceutical production, are very important.
Predicting the survival of patients with glioblastoma using deep learning: a systematic review
Authors: Habibi Mohammad Amin , Tajabadi Zohreh , Soltani Farsani Ali , Omid Reza , Tajabadi Zahra , Shobeiri Parnian 
Published: February 2025

Abstract

Background
High-grade gliomas (HGG) are aggressive brain tumor and despite intensive treatment strategy have a relatively low rate of overall survival (OS). There is no reliable technique for prediction of survival of HGG. We aimed to investigate the performance of deep learning (DL) algorithms for predicting OS of patients with glioblastoma.

Method
A systematic search was conducted in well-established research databases from inception to 23 May 2023 to retrieving the eligible studies. The sensitivity, specificity, and accuracy regarding DL algorithms regarding OS of glioblastoma was extracted.

Results
A total of 19 studies were included: 11 used conventional neural networks (CNNs) and eight used support vector machines (SVM). 17 studies performed validation, with 16 using cross-validation or Leave-One-Out Cross-validation. The radiomics features extracted varied from 3 to 17,441. Transfer learning was used in 6 studies. Several studies evaluated the accuracy, sensitivity, specificity, and AUC of DL models for GBM survival prediction. The accuracy ranged from 46.4 to 98.4% for CNNs to SVMs models. Sensitivity varied from 42.9 to 96.5%, while specificity ranged from 16.7 to 99.0%. The AUC values ranged from 61.4 to 85% for CNNs and SVMs models.

Conclusion
Depending on multiparametric imaging data, DL can help with glioblastoma patient stratification, but external multicenter repeatability studies are needed before therapeutic integration. Radiomics-guided precision oncology shows promise for optimizing glioblastoma care. Future research should focus on developing predictive models that incorporate larger patient cohorts and more robust imaging modalities. Dataset harmonization is also necessary for effective risk categorization.
Recommendations on neurologic, cognitive, and psychiatric manifestations in patients with Sjögren’s disease by the Brazilian Society of Rheumatology
Authors: de Oliveira Fabiola Reis , Appenzeller Simone , Pasoto Sandra Gofinet , Fernandes Marilena Leal Mesquita Silvestre , Lemos Lopes Maria Lucia , de Magalhães Souza Fialho Sonia Cristina , Pinheiro Aysa Cesar , dos Santos Laura Caldas , Valim Valeria , Serrano Erica Vieira , Ribeiro Sandra Lucia Euzébio , Libório‑Kimura Tatiana Nayara , do Egypto Danielle Christinne Soares , Cantali Diego Ustárroz , Gennari Juliana D’Agostino , Miyamoto Samira Tatiyama , Capobianco Karina Gatz , Pugliesi Alisson Aliel Vigano , Civile Vinicius Tassoni , Pinto Ana Carolina Pereira Nunes , Rocha-Filho César Ramos , da Rocha Aline Pereira , Trevisani Virginia Fernandes Moça 
Published: February 2025

Abstract

Background
Neurological and psychiatric manifestations occur in patients with primary Sjogren’s disease (SjD) with a wide-ranging clinical presentation, affecting quality of life, social participation, and prognosis. Despite this, neither central nor peripheral neurological symptoms are systematically evaluated in the context of autoimmunity or identified as manifestations of SjD. The EULAR Sjogren’s Syndrome Disease Activity Index (ESSDAI) covers only part of them in the neurological domain.

Methods
We performed a systematic review of the diagnosis and prevalence of central, peripheral, and autonomic nervous system manifestations in primary SjD, following the recommendations proposed by the Cochrane Collaboration Handbook. Observational studies were included when their main issue was the diagnosis and the prevalence of the manifestations individually. We employed a generalized linear mixed model (GLMM) method with a random-effects model, and the results were computed using logit transformation, implemented through the ‘meta’ and ‘metafor’ packages in the R software (version 3.6.1). To present these recommendations, agreement among experts was investigated using the Delphi method in in-person meetings.

Results
We propose ten recommendations regarding the investigation and management of neurological involvement in SjD that had 100% agreement among participants.

Conclusion
These recommendations add to the literature on the clinical care of patients with SjD.
G protein-coupled receptor 107 deficiency promotes development of diabetic nephropathy
Authors: Xu Deping , Tong Ziwen , Yang Ping , Chen Qiong , Wang Suhua , Zhao Wei , Han Linzi , Yin Yu , Xu Ruyue , Zhang Min , Cai Chunlin , Wang Deguang , Zang Dandan , Zhou Guoling , Zhou Haisheng 
Published: February 2025

Abstract
Diabetic nephropathy (DN) is characterized by glomerular basement membrane (GBM) thickening, primarily due to the abnormal accumulation of collagen type IV (COL4) in the extracellular matrix (ECM) of podocytes. Podocytes endocytosis is crucial for maintaining COL4 balance and GBM integrity. Previous studies have shown that G protein-coupled receptor 107 (GPR107) facilitates clathrin-dependent transferrin internalization and recycling in murine embryonic fibroblast cells. Therefore, the aim of the study is to investigate the role of GPR107 in regulating COL4 balance within the podocytes ECM and its potential as a therapeutic target for DN. Here, we found a significant decrease in GPR107 expression in renal tissues from DN patients and streptozocin (STZ)-induced DN mice. Furthermore, GPR107-deficient mice with STZ-induced DN exhibited more severe kidney damage, marked by increased GBM thickening and COL4 accumulation. In vitro, GPR107 deficiency under high-glucose conditions promoted COL4 accumulation in the ECM of podocytes due to increased COL4 production and decreased COL4 degradation. Mechanistically, we demonstrated that GPR107 contributes to angiotensin II receptor type 1 (AT1R) internalization through clathrin-mediated endocytosis (CME) in podocytes. Therefore, GPR107 deficiency impairs AT1R internalization, leading to increased membrane-bound AT1R. This, in turn, activates the AT1R/Ca2+ signaling pathway to promote phosphorylation of cAMP-response element-binding protein (CREB), ultimately enhancing COL4 synthesis and inhibiting the expression of matrix metalloproteinase 2 (MMP-2). These findings shed light on new functions of GPR107 in DN and offer new insights into a therapeutic target for DN.
Transoral Robotic Surgery in the Multidisciplinary Care of Patients With Oropharyngeal Squamous Cell Carcinoma: ASCO Guideline
Authors: Holsinger F. Christopher , Ismaila Nofisat , Adkins Douglas R. , Barber Brittany R. , Burnette Graham , Fakhry Carole , Galloway Thomas J. , Goepfert Ryan P. , Miles Brett A. , Paleri Vinidh , Patel Ashish A. , Roof Scott A. , Starmer Heather M. , Yom Sue S. , Saba Nabil F. , Li Ryan , Ku Jamie A. 
Published: February 2025

ASCO Guidelines provide recommendations with comprehensive review and analyses of the relevant literature for each recommendation, following the guideline development process as outlined in the

ASCO Guidelines Methodology Manual

. ASCO Guidelines follow the

ASCO Conflict of Interest Policy for Clinical Practice Guidelines

.

Clinical Practice Guidelines and other guidance (“Guidance”) provided by ASCO is not a comprehensive or definitive guide to treatment options. It is intended for voluntary use by clinicians and should be used in conjunction with independent professional judgment. Guidance may not be applicable to all patients, interventions, diseases or stages of diseases. Guidance is based on review and analysis of relevant literature and is not intended as a statement of the standard of care. ASCO does not endorse third-party drugs, devices, services, or therapies and assumes no responsibility for any harm arising from or related to the use of this information. See complete disclaimer in
Appendix 1
and
2
(online only) for more

.

PURPOSE
To provide evidence-based recommendations for the use of transoral robotic surgery (TORS) in the multidisciplinary management of oropharyngeal squamous cell cancer (OPC).

METHODS
ASCO convened a multidisciplinary Expert Panel to evaluate the evidence and formulate recommendations. The literature search included studies published between January 1, 2002, and August 31, 2024, and comprised systematic reviews, meta-analyses, randomized controlled trials, and observational studies. Outcomes of interest include overall and disease-free survival, functional outcomes, and quality of life. Expert Panel members used available evidence and informal consensus to develop evidence-based guideline recommendations.

RESULTS
A total of 58 publications were identified to inform the evidence base for this guideline.

RECOMMENDATIONS
Evidence-based recommendations address the evaluation and workup of patients with human papillomavirus (HPV)–positive OPC, the role of TORS, patient selection, adjuvant therapy, HPV-negative OPC, and use of TORS in salvage or recurrent setting.

Additional information is available at
www.asco.org/head-neck-cancer-guidelines
.