bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of elevated body mass index (BMI) on cognitive functioning and inflammation in persons with post-COVID-19 condition: a secondary analysis
Authors: Le Gia Han , Kwan Angela T.H. , Guo Ziji , Wong Sabrina , Badulescu Sebastian , Gill Hartej , Teopiz Kayla M. , Meshkat Shakila , Ceban Felicia , Phan Lee , Subramaniapillai Mehala , Di Vincenzo Joshua D. , Rosenblat Joshua D. , Mansur Rodrigo B. , d’Andrea Giacomo , Ho Roger , Rhee Taeho Greg , McIntyre Roger S. 
Published: April 2024

AbstractBackground:Individuals who have recovered from the acute stage of SARS-CoV-2 infection may be at risk of developing post-COVID-19 condition (PCC), characterised by a spectrum of persisting, non-specific, and functionally impairing symptoms across multiple organ systems. Obesity has been implicated as a risk factor for PCC, mediated by chronic systemic inflammation. The foregoing has also been separately reported to mediate cognitive dysfunction in PCC.Methods:This is a post-hoc analysis of a randomised, double-blinded, placebo-controlled clinical trial evaluating vortioxetine treatment for cognitive impairments in persons with PCC who received vortioxetine or placebo for eight weeks. This analysis comprises baseline data, examining the impact of BMI on cognitive functioning measured by the Digit Symbol Substitution Test (DSST) and Trails Making Tests (TMT)-A/B, as well as inflammation, via serum c-reactive protein (CRP) and erythrocyte sedimentation rate (ESR).Results:Complete data from 70 participants were statistically analysed and adjusted for age and sex. BMI was negatively correlated with performance on the DSST (β = −0.003, p = 0.047), TMT-A (β = −0.006, p = 0.025), and TMT-B (β = −0.006, p = 0.002). BMI was positively correlated with serum CRP (unstandardized β = 0.193, standardized β = 0.612, p < 0.001) and ESR (β = 0.039, p < 0.001) levels.Conclusion:We observed a significant negative correlation between BMI and cognitive functioning, and a significant positive correlation between BMI and inflammation in persons with PCC, suggesting a bidirectional interplay between BMI, PCC, and cognitive function; individuals with an elevated BMI may be at a greater risk of developing PCC and/or presenting with greater cognitive deficits mediated by chronic systemic inflammation.
Epidemiology of Echinococcus granulosus in Arbil province, northern Iraq, 1990–1998
Authors: Saeed I. , Kapel C. , Saida L.A. , Willingham L. , Nansen P. 
Published: April 2024

AbstractDuring the period 1990–1998, 99 cases of human cystic hydatidosis (12.4 cases per year) were surgically treated at the two main hospitals in Arbil province, northern Iraq, and from this the human occurence for the province was estimated to be 2 per 100,000 inhabitants. In the same area, 1270 sheep, 550 goats and 320 cattle were examined at slaughter for hydatid cysts and prevalence rates were found to be 15.0%, 6.2% and 10.9%, respectively. A decreasing tendency in livestock prevalences was found towards the end of the study period. As in humans, most of the hydatid cysts in livestock were located in the liver. Fertility of sheep cysts, i.e. those containing protoscoleces, was found to be significantly higher (64%) than that of goats (35.7%) and cattle (29.8%). The percentage of fertile cysts containing viable protoscoleces varied between 63 and 82% in the livers and between 72 and 79% in the lungs of the different animal species. A total of 97 stray dogs were examined post-mortem in the years 1991, 1992 and 1998, and Echinococcus granulosus worms were found in the intestines of 48 dogs (49.5%). High worm burdens (> 1000) were observed in 37% of the dogs, medium worm burdens (200–1000) in 41%, and low worm burdens (< 200) in 22%. In 1998, the prevalence of canine echinococcosis (24.3%) was found to be significantly lower than in 1991 (70.4%) and 1992 (60.6%). The prevalence of human hydatidosis did not differ significantly over the years, but the study confirmed that hydatidosis is endemic in northern Iraq, and that housewives, labourers and farmers appear to be at the greatest risk of infection.
Nematode parasite control practices of sheep and goat farmers in the region of Trikala, Greece
Authors: Theodoropoulos G. , Theodoropoulos H. , Zervas G. , Bartziokas E. 
Published: April 2024

AbstractInformation concerning worm control practices of sheep and goat farmers in the region of Trikala (central Greece) was collected through a questionnaire survey by visiting farms and interviewing farmers. Questionnaires from 57 farmers residing in 23 rural communities were collected. Anthelmintics were used by 89% of the farmers. On average, lambs, kids and goats were treated once annually, while sheep were treated either once or twice annually. Only 2% of farmers reported treatment of animals with anthelmintics when moving to new pastures. The most common broad-spectrum anthelmintics used were those belonging to the benzimidazoles and probenzimidazoles. Fifty nine percent of the farmers used the same anthelmintic group for 3 or more years and 34% used two or more anthelmintic groups in the same year. Almost all farmers reported estimating live weights for calculating anthelmintic doses through visual perception on the basis of an average weight (96%). Tablets and boluses were the most preferred anthelmintic formulation used by 96% of farmers. The selection of an anthelmintic was based for 58% of farmers on recommendation by a veterinarian and for 39% of farmers on the cost of the drug. The most common occasions for deworming the animals were at turn out (86%) and after parturition (31%). Only 6% of farmers reported deworming new animals before introducing them onto the farm. Farmers preferred to seek information about the use of anthelmintics and worm control strategies from veterinarians (63%) and other farmers (37%).
The life cycle and transmission dynamics of the larval stages of Hypoderaeum conoideum
Authors: Muñoz-Antolí C. , Toledo R. , Esteban J.G. 
Published: April 2024

AbstractThe morphology of the different larval stages and life cycle of Hypoderaeum conoideum (Trematoda: Echinostomatidae) are described. The freshwater snail species Lymnaea peregra (Gastropoda: Lymnaeidae) serves as the natural first intermediate host and this and L. corvus serve as experimental first intermediate hosts. These and other freshwater snails, such as Physella acuta and Gyraulus chinensis, in turn serve as second intermediate hosts. Adult worms were obtained from chicks and ducks, but not from rats, mice and golden hamsters. The morphology of the larval stages is compared with previous work on H. conoideum. Several aspects of the biology of the life history stages are described with emphasis on the transmission dynamics of the free-living stages. Differential suitability of the snail species that may act as first and/or second intermediate hosts is studied and discussed.
In vitro interactions between epithelial cells and Gyrodactylus derjavini
Authors: Buchmann K. , Nielsen C.V. , Bresciani J. 
Published: April 2024

AbstractSkin responses of fish to various parasites have been shown to involve various immunologically competent cells producing factors which guide the reactions of epithelial cells. However, the present study has demonstrated that a monoculture of epithelial cells has the ability to encapsulate and partially degrade ectoparasites without involvement of leukocytes. The ectoparasitic monogeneanGyrodactylus derjavini was kept on a monolayer of Epithelioma Papulosum Cyprini (EPC) cells in 24-well multidishes supplied with tissue culture medium. Gyrodactylus derjavini did not reproduce but survived an incubation period of up to139 h in the system. Due to sterile conditions, dead gyrodactylids were not subjected to microbial degradation and remained intact for several weeks. However, at 40 days G. derjavini was overgrown by EPC-cells and became partly degraded during the following 15 days. Analysis of enzyme reactivity in EPC-cells showed reactions for ten enzymes including esterases, amidases, phosphatases and phosphohydrolases. No marked differences for the ten enzymes between cell cultures with and without the ectoparasites were found but it cannot be excluded that some of these enzymes took part in parasite degradation. The study showed the in vitro capability of epithelial cells to interact, encapsulate and degrade G. derjavini without the involvement of leukocytes. This response probably is non-specific and will not exclude that various immunocompetent cells and their products normally optimize and accelerate elimination of invading parasites in vivo.
Comparison of IgG3 responses to carbohydrates following mouse infection or immunization with six species of Trichinella
Authors: Dea-Ayuela M.A. , Martinez-Fernandez A.R. , Bolas-Fernandez F. 
Published: April 2024

AbstractThe IgG3 antibody responses to carbohydrate epitopes were compared in BALB/c mice infected or immunized with six species of Trichinella: T. spiralis (T1), T. nativa (T2), T. britovi (T3), T6, T. nelsoni (T7), and T8. The dynamics of IgG3 responses and antigen recognition following infection or immunization were measured by ELISA and Western blot respectively, using glycosylated and deglycosylated larval crude extracts (LCE) prepared from homologous isolates. A high degree of protein glycosylation was found in all species and with similar profiles. Deglycosylation was completely achieved only in LCE from T1 and T6 isolates. The dynamics of IgG3 responses following infection or immunization significantly differed whereas the antigen recognition profiles appeared similar. Variations in the levels and antigen recognition patterns of IgG3 among the different species were apparent. The highest IgG3 levels were recorded in infections by the T8 isolate and the lowest in infections by the T6 isolate, whereas for immunization the highest IgG3 response was induced by T7 and the lowest by T8. Following antigen deglycosylation, the IgG3 responses were significantly reduced or abrogated and the recognition patterns markedly modified or suppressed in the different species of Trichinella.
The intensity and duration of primary Heligmosomoides polygyrus infection in TO mice modify acquired immunity to secondary challenge
Authors: Fakae B.B. , Harrison L.J.S. , Sewell M.M.H. 
Published: April 2024

AbstractThe effect of dose and duration of immunizing infections of Heligmosomoides polygyrus on protection against homologous challenge was studied in female TO mice. Primary infections were terminated at various levels with pyrantel embonate (adult infections) or ivermectin (larval infections) and mice were then challenged with 500 infective larvae (L3). The level of protection to secondary challenge positively correlated with the intensity of the primary immunizing infection but truncation of larval infection produced significantly better protection than termination of the adult nematode infection. The duration of the primary larval infection (1–6 days) positively correlated with the level of protection to secondary challenge, antibody responses and the proportion of circulating eosinophils. Histological changes in the gastrointestinal tract, peripheral leucocytic changes and antibody responses of the mice to H. polygyrus adult somatic antigens indicate both a cellular and humoral basis of host immunity to secondary challenge. Although the TO mice are slow responders in that they harbour chronic infections, immunization by intramucosal killing of the larval stage produced strong protection against secondary challenge infection. The presence of dead immunogenic larval stages within the intestinal wall may well be an important factor, since it exposes the host to stage specific antigens at an appropriate location. The implications of the findings for the control of gastrointestinal nematode infections are also discussed.
Allometric growth of the proglottids and strobila of the tapeworm, Hymenolepis diminuta
Authors: Pappas P.W. 
Published: April 2024

AbstractHymenolepis diminuta adults were killed and fixed in fully extended positions, and the total lengths of the strobilae, numbers of proglottids, and distances of proglottids along the strobilae were determined. The relationship of proglottid number to distance along the strobila was exponential. Beginning at proglottid 100 (P100), the lengths and widths of proglottids at 100 proglottid intervals were determined, and the surfaces areas were calculated. The relationships of proglottid length and width to proglottid number were linear, but the relationship of proglottid number to surface area (SA) was exponential. The volumes of proglottids were calculated, and the relationship of volume (V) to proglottid number was exponential. The relationship of surface area to volume ratio (SAVR) to proglottid number was exponential; at the anterior end of the worm (P100), the SAVR was 14.6, while at the posterior end of the worm (P1300) the ratio was 4.2. A single exponential equation describing the relationships among proglottid number, SA, and V was derived.
Congenital transmission of Schistosoma japonicum in the rabbit
Authors: Qian B.-Z. , Bøgh H.O. , Johansen M.V. , Wang P.P. 
Published: April 2024

AbstractFourteen pregnant rabbits were each infected with 300 cercariae of Schistosoma japonicum and divided into two groups. Group M (n = 8) was infected during mid-gestation (the organogenetic stage) and group L (n = 6) was infected during late-gestation (the post-organogenetic stage). Mother rabbits and rabbit kittens were killed 45–60 days after infection and perfused in order to obtain worm counts. Furthermore, faecal egg counts and tissue egg counts from livers were obtained from the mother rabbits as well as the rabbit kittens. All mother rabbits became infected harbouring 207.6 ± 20.2 and 220.0 ± 27.5 adult worms in group M and L, respectively. In groups M and L, 13.5% and 46.7% of the kittens were infected, respectively. In 12 of 14 litters at least one kitten was infected. The infected kittens harboured between one and three adult S. japonicum. The livers of the kittens infected with a worm pair displaced lesions as a result of egg deposition. The results, therefore, show that congenital transmission of S. japonicumcan occur in rabbits. The close anatomical resemblance between the rabbit and human placenta may be indicative of the presence of congenital transmission of S. japonicum infection in humans.
Setaria digitata infections in cattle: parasite load, microfilaraemia status and relationship to immune response
Authors: Mohanty M.C. , Sahoo P.K. , Satapathy A.K. , Ravindran B. 
Published: April 2024

AbstractA total of 110 cattle were examined in an area endemic for Bancroftian filariasis for the prevalence of infection of the bovine filarial parasite Setaria digitata. About 12.5% of cattle were found to harbour both adult worms in the peritoneum and microfilariae (mf) in circulation; 70% of the cattle were amicrofilaraemic but with an adult worm infection. A third group of cattle (16.5%) was free of detectable mf and adult worms. The presence of adult worms and/or mf did not influence the antibody levels to any of the four antigen preparations of S. digitata. However, there was a significant inverse relationship between the presence of antibodies to microfilarial sheaths and the absence of circulating mf as shown by the immunoperoxidase assay. Cattle immunoglobulin containing high titres of anti-sheath antibodies cleared circulating microfilariae very effectively in Mastomys coucha thus demonstrating the protective nature of anti-sheath antibodies in eliminating circulating microfilariae in vivo.
Utility of maximum phonation time in the diagnosis of spasmodic dysphonia (laryngeal dystonia)
Authors: Kapoor Nerurkar Nupur , Goyal Sakshi 
Published: April 2024

AbstractObjectivesMaximum phonation time is a simple test used to assess glottic competency. Our objective was to evaluate any correlation between maximum phonation time and spasmodic dysphonia as adductor spasmodic dysphonia and abductor spasmodic dysphonia have an adductor and abductor overdrive, respectively.MethodsA 3-year data-review was performed for patients diagnosed with adductor spasmodic dysphonia, abductor spasmodic dysphonia and mixed spasmodic dysphonia. Maximum phonation time was noted on the first visit and compared with a control group.ResultsAverage maximum phonation time in adductor spasmodic dysphonia, abductor spasmodic dysphonia and control group was 25 seconds, 9 seconds and 16 seconds. A significant difference was found for adductor spasmodic dysphonia and abductor spasmodic dysphonia. A receiver operating characteristic curve analysis between adductor spasmodic dysphonia and control groups showed a positive predictive value of 81.3 per cent, negative predictive value of 83.9 per cent, sensitivity of 79.6 per cent and specificity of 85.2 per cent. Level of evidence = 4.ConclusionWe recommend that maximum phonation time be added to the diagnostic armamentarium of spasmodic dysphonia. This correlation between maximum phonation time and spasmodic dysphonia has not been previously published.
Statistics versus semantics: retreating from the dative overgeneralization errors by Chinese EFL learners
Authors: Xiang Keshu , Wei Jianhui , Chen Yuanyan 
Published: April 2024

AbstractThis study investigated the effects of entrenchment, preemption, verb semantics, and morphophonological constraints in Chinese EFL (English as a Foreign Language) learners’ retreat from the overgeneralization errors of English dative alternations. Two groups of Chinese EFL learners rated the acceptability of 66 dative verbs in their well and ill forms. The results demonstrated that Chinese EFL learners were simultaneously sensitive to the multiple cues from entrenchment, preemption, semantic, and morphophonological constraints, indicating that Chinese EFL learners restricted the generalization of the dative alternation by utilizing both the statistical verb-bias information and semantic properties of the dative verbs. Moreover, the sensitivity of Chinese EFL learners to these constraints increases with the improvement of their English proficiency. These results validated the usage-based approaches to second language acquisition and provided an answer to the “Baker’s Paradox.”
Anti-Muslim policy preferences and boundaries of American identity across partisanship
Authors: Lajevardi Nazita , Oskooii Kassra A. R. 
Published: April 2024

AbstractDoes American identity predict preferences for anti-democratic policies that aim to marginalize Muslim Americans? Absent significant priming of inclusive elements of American identity, we argue that individuals with stronger attachments to American identity will be less likely than their counterparts to reject a range of anti-Muslim policies that are antithetical to principles of religious liberty and equality. Across three surveys and multiple measures, American identity powerfully predicts preferences for curbing the civil liberties of Muslim citizens. Particularly striking is the finding that the effect of American identity spans the partisan divide; it consistently explains the endorsement of exclusionary policies among self-identified Democrats, who typically hold more progressive policy positions toward minority groups than Republicans. Overall, our study highlights the contradictory and exclusionary nature of American identity, which has important implications for minority groups constructed as outside the boundaries of Americanness.
Transformative justice as a method in applied linguistics
Authors: Cushing Ian 
Published: April 2024

AbstractTransformative justice is a vision, a framework, and a theory of change which pushes for radical abolition and reimagining of entire systems. It is a community-led strategy which centers on and seeks to uproot structural determinants of oppression. In this article, I outline how applied linguistics can and should draw on transformative justice principles as a methodology for doing applied linguistics and as an underpinning theory of change for the discipline itself. I explore how transformative justice in applied linguistics involves addressing the colonial roots of the discipline and its complicity in perpetuating raciolinguistic ideologies and co-constituted discourses of linguistic deficiency. I argue for new conceptualizations of impact which prioritize community solidarity. I argue for applied linguists to end collaborations with the police, the military, and the prison industrial complex, showing how these collaborations rely on systems of punitive accountability and modest reforms. I argue that transformative justice is a life-affirming theory of change for the discipline of applied linguistics and for the marginalized communities we work with.
Study quality as an intellectual and ethical imperative: A proposed framework
Authors: Plonsky Luke 
Published: April 2024

Abstract
What is quality in the context of applied linguistic research? Addressing this question is both an intellectual and ethical imperative for the field. Toward that end, I propose a four-part framework for understanding and evaluating study quality: Quality research is (a) methodologically rigorous, (b) transparent, (c) ethical, and (d) of value to society. The bulk of the paper is devoted to describing each of these four elements, first conceptually and then as observed in the field. I also articulate some of the many connections among the four elements within the framework. In addition, I suggest next steps for further addressing the notion of quality in terms of the framework itself as well as the ways it might be used to advance our field’s research, training, and legitimacy as an academic discipline that is still in some ways coming of age.
Complex adaptive interventions: The challenge ahead for instructed second language acquisition research
Authors: Hiver Phil , Nagle Charlie 
Published: April 2024

Abstract
The effects of deliberately and selectively manipulating instructional conditions are at the heart of instructed second language acquisition (ISLA) research and, ideally, are designed to inform practice. Knowing how an intervention works, by what mechanisms and processes the treatment is beneficial—and for whom—are complex questions. In this piece, we problematize intervention-based research paradigms that do not account for context, individuals and their proactivity, or temporal variation. We highlight several key challenges that remain for ISLA research and propose a more reflexive approach to intervention that attends to these central considerations in implementing study designs.
Estimating the Impact of Rural Hukou Status on Earnings for College Graduates in China
Authors: Wang Huan , Cousineau Claire , Boswell Matthew , Li Hongbin 
Published: April 2024

AbstractA growing body of literature explores the effect of higher education on the urban–rural divide in China. Despite an increasing number of rural students gaining access to college, little is known about their performance in college or their job prospects after graduation. Using nationally representative data from over 40,000 urban and rural college students, we examine rural students’ college performance and estimate the impact of rural status on students’ first job wages in comparison to their urban peers. Our results indicate that once accepted into college, rural students perform equally as well, if not better, than their urban counterparts. Additionally, we discovered that rural students earn a 6.2 per cent wage premium compared to their urban counterparts in their first job after graduation. Our findings suggest the importance of expanding access to higher education for rural students, as it appears to serve as an equalizer between urban and rural students despite their significantly different backgrounds.