bluuebunny/crossref_metadata_2025_split huggingface dataset:
Full-body Postural Alignment Analysis Through Barycentremetry
Authors: Khalifé Marc , Vergari Claudio , Assi Ayman , Guigui Pierre , Attali Valérie , Valentin Rémi , Vafadar Saman , Ferrero Emmanuelle , Skalli Wafa 
Published: April 2024

Study Design.
A multicentric retrospective study.

Objective.
The study of center of mass (COM) locations (ie, barycentremetry) can help us understand postural alignment. The goal of this study was to determine relationships between COM locations and global postural alignment x-ray parameters in healthy subjects. The second objective was to determine the impact on the spinopelvic alignment of increased distance between the anterior body envelope and spine at the lumbar apex level.

Summary of Background Data.
Unexplored relationship between COM location and spinopelvic parameters.

Methods.
This study included healthy volunteers with full-body biplanar radiographs, including body envelope reconstruction, allowing the estimation of COM location. The following parameters were analyzed: lumbar lordosis (LL), thoracic kyphosis (TK), cervical lordosis (CL), pelvic tilt (PT), sacro-femoral angle (SFA), knee flexion angle (KFA), and sagittal odontoid-hip axis angle (ODHA). The following COM in the sagittal plane were located: whole body, at a thoracolumbar inflection point, and body segment above TK apex. The body envelope reconstruction also provided the distance between the anterior skin and the LL apex vertebral body center (“SV-L distance”).

Results.
This study included 124 volunteers, with a mean age of 44±19.3. Multivariate analysis confirmed the posterior translation of COM above TK apex with increasing LL (P=0.002) through its proximal component and posterior shift of COM at the inflection point with increasing TK (P=0.008). Increased SV-L distance was associated with greater ODHA (r=0.4) and more anterior body COM (r=0.5), caused by increased TK (r=0.2) and decreased proximal and distal LL (both r=0.3), resulting in an augmentation in SFA (r=0.3) (all P<0.01).

Conclusions.
Barycentremetry showed that greater LL was associated with a posterior shift of COM above the thoracic apex, while greater TK was correlated with more posterior COM at inflection point. Whole-body COM was strongly correlated with ODHA. This study also exhibited significant alignment disruption associated with increased abdominal volume, with compensatory hip extension.

Level of Evidence.
Level—II.
Head and neck cancer patients treated with concomitant chemoradiotherapy involving the oral cavity and oropharynx: is another choice possible than prophylactic gastrostomy?
Authors: Senesse Pierre , Briant Jeanne , Boisselier Pierre , Bensadoun René-Jean , Vinches Marie , Faravel Kerstin 
Published: April 2024

Purpose of reviewRecent recommendations on cachexia highlight, in head and neck cancers, the heterogeneity of studies, focusing on weight loss and sequelae including swallowing disorders. The current national guidelines emphasize that, in cases of concurrent chemoradiotherapy (cCRT) involving the oral cavity and oropharynx, prophylactic gastrostomy placement should be carried out systematically. We review why this technique is particularly relevant in this specific location for the feasibility of cCRT.Recent findingsA randomized trial is underway on swallowing disorders and the quality of life of patients after prophylactic vs. reactive gastrostomy in advanced oropharyngeal cancer patients treated with CRT. Concurrently, recent literature reviews emphasize the importance of the cumulative dose of chemotherapy for local control and survival. In cases of cCRT involving the oral cavity or the oropharynx, nutritional support could have a beneficial or detrimental impact on chemotherapy.SummarySpecifically for patients treated with cCRT involving the oral cavity and oropharynx, prophylactic gastrostomy would be able to fulfill the three objectives of local control, survival, and quality of life, minimizing complications related to nutritional support. Studies need to be more homogeneous. In clinical practice, nutrition should primarily assist in carrying out cancer treatment when survival is the main goal.
A Novel Large Deletion in the EVER1 Gene in a Family With Epidermodysplasia Verruciformis From India
Authors: Godfred Adithya Christopher , Thomas Zachariah , Peter Dincy , Joseph Anjana , Ravichandran Lavanya , George Anu Anna , Pulimood Susanne A. , Gaikwad Pranay , Babu Ramesh , Thomas Meera , Thomas Nihal , Chapla Aaron 
Published: April 2024

Abstract:
Epidermodysplasia verruciformis (EV) is a rare autosomal recessive genodermatosis due to mutations in EVER1 and EVER2 genes. The genetic profile of Indian patients with EV has not been previously studied. This report describes the clinical presentation and molecular analysis of a family with EV. Using genomic DNA from two affected probands and healthy controls (two other siblings), conventional polymerase chain reaction (PCR) was conducted with novel primer sets designed to amplify the coding and splice-site regions in the genes EVER1 and EVER 2. This revealed no amplification with a primer set for exons 16 to 18 in the EVER1 gene of both the probands. Subsequently, long-range PCR spanning the length of exon 15–20 and next-generation sequencing demonstrated a homozygous deletion of 2078 bp in the EVER1 gene (EVER1:c.2072_2278del). Screening the family revealed the same homozygous deletion (similar to index cases) in two other affected siblings. The parents and two asymptomatic siblings were heterozygous carriers for the deletion while one healthy sibling was negative. These results were validated with Sanger sequencing. This deletion in exons 17 and 18 of the EVER1 gene results in a frameshift, followed by a premature termination resulting in a severe phenotype. The identification and validation of this large deletion was detected using stepwise amplicon-based target enrichment and long-range PCR, respectively. In this family, this simple strategy greatly enhanced genetic counseling as well as early genetic diagnosis and screening. However, functional assays and larger studies are required to characterize and validate the genetic diversity among Indians with EV.
Granulomatous Slack Skin With Lung and Esophagus Involvement: A Case Report and Molecular Analysis
Authors: Pereira Filipa Galante , Esteves Gonçalo , Costa Rosa Joaninha , Cabeçadas José , Cravo Mariana , Pereira Maria Inês Matos Silva Barbosa , Robson Alistair 
Published: April 2024

Abstract:
Granulomatous slack skin (GSS) is a rare subtype of mycosis fungoides, and few cases have been known to spread to the blood, lymph nodes, or viscera. We present a case with early dissemination to the lung. A 27-year-old woman, previously healthy, presented with scattered disseminated scaly patches, associated with vulvar and intergluteal firm swelling and groin-skin induration for 1 year. She also reported mild fatigue and breathlessness on moderate exertion. The patient underwent blood tests, skin biopsies, and computed tomography scan. The skin biopsy showed a mildly atypical T-cell lymphoid infiltrate involving the dermis/hypodermis, with focal epidermotropism, associated with a granulomatous infiltrate and elastophagocytosis. The computed tomography scan revealed bilateral ground-glass lung nodular opacities. Positron emission tomography showed an increased signal in the skin and subcutis around the buttocks, inguinal and mediastinal lymph nodes, and lungs. The lung biopsy confirmed a dense T-cell infiltrate with numerous multinucleated giant cells. Subsequently, esophageal involvement was also observed following biopsy. Molecular analyses demonstrated identical T-cell clones in the skin and lung. After 6 cycles of chemotherapy/localized external radiotherapy, the patient had a partial skin response and stable lung disease. A preferred diagnosis of GSS with systemic spread was made based on clinical/histologic/molecular findings, after considering granulomatous mycosis fungoides and peripheral T-cell lymphoma, not otherwise specified. This case highlights the frequent diagnostic difficulty in distinguishing GSS from an inflammatory granulomatous dermatitis. Pulmonary and esophageal involvements are rare in GSS, and the simultaneous presentation of characteristic cutaneous GSS with systemic disease poses an additional classification challenge.
Oxyberberine sensitizes liver cancer cells to sorafenib via inhibiting NOTCH1-USP7-c-Myc pathway
Authors: Sun Liangbo , He Meng , Li Feng , Wu Di , Zheng Ping , Zhang Cong , Liu Yang , Liu Dong , Shan Meihua , Yang Mingzhen , Ma Yuanhang , Lian Jiqin , Xiong Haojun 
Published: April 2024

Background:
Sorafenib is the first-line therapy for patients with advanced-stage HCC, but its clinical cure rate is unsatisfactory due to adverse reactions and drug resistance. Novel alternative strategies to overcome sorafenib resistance are urgently needed. Oxyberberine (OBB), a major metabolite of berberine in vivo, exhibits potential antitumor potency in various human malignancies, including liver cancer. However, it remains unknown whether and how OBB sensitizes liver cancer cells to sorafenib.

Methods:
Cell viability, trypan blue staining and flow cytometry assays were employed to determine the synergistic effect of OBB and sorafenib on killing HCC cells. PCR, western blot, co-immunoprecipitation and RNA interference assays were used to decipher the mechanism by which OBB sensitizes sorafenib. HCC xenograft models and clinical HCC samples were utilized to consolidate our findings.

Results:
We found for the first time that OBB sensitized liver cancer cells to sorafenib, enhancing its inhibitory effect on cell growth and induction of apoptosis in vitro. Interestingly, we observed that OBB enhanced the sensitivity of HCC cells to sorafenib by reducing ubiquitin-specific peptidase 7 (USP7) expression, a well-known tumor-promoting gene. Mechanistically, OBB inhibited notch homolog 1-mediated USP7 transcription, leading to the downregulation of V-Myc avian myelocytomatosis viral oncogene homolog (c-Myc), which synergized with sorafenib to suppress liver cancer. Furthermore, animal results showed that cotreatment with OBB and sorafenib significantly inhibited the tumor growth of liver cancer xenografts in mice.

Conclusions:
These results indicate that OBB enhances the sensitivity of liver cancer cells to sorafenib through inhibiting notch homolog 1-USP7-c-Myc signaling pathway, which potentially provides a novel therapeutic strategy for liver cancer to improve the effectiveness of sorafenib.
Zonulopathy and Its Relation to Primary Angle Closure Disease: A Review
Authors: Huang Jie , Huang Chukai 
Published: April 2024

Précis:
This paper aims to discuss the anatomical features of zonule fibers that center the lens in the eye and summarizes the relationship between zonulopathy and PACD.

Abstract:
The increasing lens vault (LV) and lens thickness (LT) is a recognized mechanism for primary angle closure glaucoma (PACG). Zonulopathy, causing the abnormal lens position, is an important factor in this mechanism. Several anatomically distinct sets of zonular fibers are present in primate eyes, including ciliary zonules, vitreous zonules, and attachments between the posterior insertion zone of the vitreous zonules and the posterior lens equator (PVZ INS-LE strands). Zonulopathy, as a clinical diagnosis, exhibits zonular laxity and loss, long anterior lens zonules (LAZ). Slit lamp, gonioscopy, ultrasound biomicroscopy (UBM), anterior segment optical coherence tomography (AS-OCT) aid in the diagnosis of zonulopathy. The proportion of underdiagnosed zonulopathy among primary angle closure disease (PACD) patients before operation is high. According to the intraoperative signs, zonulopathy could be determined better. There is a high prevalence of zonulopathy among PACD patients compared with the general population. Because of the different insertion zone in lens capsules, different zonular fibers play different parts in lens position and shape. Zonular laxity and loss cause the lens to be thicker and move anteriorly, forming narrow-angle and high intraocular pressure, and then the higher intraocular pressure damages zonule fibers further and causes angle closure. Loss of vitreous zonules may make the ciliary body rotate anterior excessively and pull iris forward, leading to iridotrabecular contact. LAZ eyes tend to be hyperopic and have short axial length, increased LT and anterior lens position, plateau iris configuration, and characteristics that are consistent with elevated risk for angle closure. Zonulopathy may be a risk for PACD. A clear knowledge of zonulopathy and its relation to PACD would be helpful to the diagnosis and treatment.
Superinfections in COVID-19
Authors: Saha Arunava , Siew Michelle , Chaudhuri Sirshendu , Agiwal Varun , Abraham George M. 
Published: April 2024

IntroductionBacterial superinfection rates in SARS-CoV-2 (COVID-19) range from 8% to 49.6%, but the diagnosis remains a challenge. We conducted a study to determine the utility of the Pneumonia Severity Index (PSI) to predict the risk of superinfections and outcomes in COVID-19 patients.MethodsA cross-sectional retrospective study was conducted on COVID-19 positive patients admitted during 2020–2022. The PSI scores were calculated at admission and at every 72-hour intervals. Data regarding clinical course, antibiotic use and overall outcome were collected.ResultsA total of 149 patients were included, with a mean age of 67 years. The PSI score at admission and the mean PSI score were higher for those who required antibiotics, intensive care unit (ICU) admission, or succumbed. Patients with a PSI score >107 at admission had a high risk of ICU admission, >113 had a high risk of antibiotic requirements, and >110 had a higher risk of death. An increase in PSI score ≥25 between the day of admission and day 3 of hospitalization; or between day 3 and day 6 of hospitalization, predicted a higher chance of mortality; but had no association with the development of superinfections.DiscussionThe PSI score at admission can be used to predict the severity of disease requiring ICU admission, antibiotic requirement, and overall mortality, with serial monitoring of the score predicting possible clinical deterioration and increased mortality. However, it was not helpful in predicting the chances of developing superinfections and the need for antibiotic therapy.ConclusionsThe PSI score can be used to prognosticate the outcome in patients admitted with COVID-19, but further studies are needed to determine its utility in predicting the risk of superinfections.
The value of cholinesterase inhibitors for improving neuropsychiatric and functional assessment scores in patients with Alzheimer disease: a systematic review and meta-analysis of on placebo-controlled RCTs
Authors: Zhang Yamin , Sun Yanqing , Hu Xiaojuan , Yao Yuping , Wang Jianping 
Published: April 2024

Introduction:
At present, increasing reports from different aspects indicated that cholinesterase inhibitors (ChEIs) may be effective on improving neuropsychiatric and functional assessment scores in patients with Alzheimer disease (AD). However, no studies comprehensively and detailedly evaluated the effect of ChEIs on AD. The present analysis was designed to comprehensively evaluate the efficacy and safety of ChEIs for AD.

Methods:
Two independent researchers systematically reviewed 1096 searching records in PubMed, Embase, Cochrane Library, and Web of Science from inception to 10 May 2023, and finally identified 12 randomized, double-blind, placebo-controlled trials with 6908 participants according to predetermined inclusion and exclusion criteria. The effects were assessed with standardized mean difference (SMD) or odds ratio (OR). The primary outcomes were the mean change and least squares (LS) mean change from baseline to endpoint of neuropsychiatric and functional assessment scores. The secondary outcome was adverse events of ChEIs when compared to placebo for patients with AD. All statistical analyses were performed using the standard statistical procedures provided in Review Manager 5.2 and and Stata 12.0.

Results:
Pooled analysis indicated that ChEIs significantly improved the assessment scores of the AD Assessment Scale (ADAS) (SMD −1.57; 95% CI: −2.64 to −0.51), Clinician’s Interview-Based Impression of Change-Plus caregiver input (CIBIC-Plus) (SMD −0.28; 95% CI: −0.41 to −0.15), the Neuropsychiatric Inventory (NPI) (both SMD −1.67; 95% CI: −2.88 to −0.47 for 10-tiem total score and SMD −1.83; 95% CI: −3.25 to −0.42 for 12-tiem total score), and the AD Cooperative Study–Activities of Daily Living (ADCS-ADL) total score (SMD 2.44; 95% CI: 1.29–3.59), evaluated with mean change from baseline to endpoint. In addition, when evaluated with the LS mean change from baseline to endpoint, ChEIs significantly improved Mini-Mental State Examination (MMSE) total score, the Clinician Interview-Based Impression of Severity, CIBIC-Plus, ADCS-ADL total score, NPI, ADAS. Regarding to adverse events (AEs) of patients with AD, it indicated that compared to placebo, ChEIs did not increase the frequency of severe and serious AEs (fatal or nonfatal) as well as the incidence of death.

Conclusions:
Our analysis indicated that ChEIs treatment generally improved neuropsychiatric and functional assessment scores in patients with AD though opposite result was observed in Wechsler Memory Scale. ChEIs had an acceptable safety profile in patients with AD without increasing of any crucial adverse or outcomes.
Quality of Life and Loneliness Among American Military Veterans
Authors: Schafer Katherine Musacchio , Campione Marie , Joiner Thomas 
Published: April 2024

Abstract
Quality of life and loneliness are closely associated with mental and physical health outcomes. This relationship is particularly important in Veterans who experience elevated rates of disabilities, comorbidities, and chronic health conditions as compared with non-Veterans. In the present project, we use data from the Military Health and Well-Being Project (n = 1469, 67.2% men, 32.3% women, 0.5% transgender, nonbinary, prefer not to say) to investigate the link between five domains of quality of life (i.e., general quality of life, physical health, psychological health, social relationships, and environment) with loneliness in American Military Veterans. Findings indicated that every domain of quality of life was negatively and significantly associated with loneliness (r's < −0.45, p's < 0.001), such that quality of life decreased as loneliness increased. We further found, using linear regression, that quality social relationships (β = −0.385, t = −13.23), psychological functioning (β = −0.196, t = −5.28), and physical health (β = −0.133, t = −4.174) were related to low levels of loneliness. Taken together, these findings indicate that in this sample of Veterans 1) general quality of life, physical health, psychological health, social relationships, and environment are all strongly connected with loneliness, and 2) of these, social relationships, psychological health, and physical health seem to protect most against loneliness, with large robust effect sizes. We recommend that intervention and policy researchers continue to investigate and develop feasible, acceptable, and cost-effective ways to promote social relationships, psychological health, and physical health among Veterans. Data were collected during the COVID-19 pandemic, which may limit generalizability of these findings.
Behavioral-Social Rhythms and Cardiovascular Disease Risk in Retired Night Shift Workers and Retired Day Workers
Authors: Tracy Eunjin Lee , Chin Brian N. , Lehrer H. Matthew , Hasler Brant P. , Thomas Mark C. , Smagula Stephen , Kimutis Sarah , Hall Martica H. , Buysse Daniel J. 
Published: April 2024

ObjectiveStability in the timing of key daily routine behaviors such as working/doing housework, sleeping, eating, and engaging in social interactions (i.e., behavioral-social rhythms) contributes to health. This study examined whether behavioral-social rhythms were associated with cardiovascular disease (CVD) risk factors in retired night shift workers and retired day workers and explored whether past night shift work exposure moderated this association.MethodsA total of 154 retired older adults participated in this study. Multiple logistic regression models were used to examine associations between behavioral-social rhythms and CVD risk factors. Independent variables included Social Rhythm Metric (SRM)-5 score and actigraphy rest-activity rhythm intradaily variability (IV) and interdaily stability (IS). Dependent variables were metabolic syndrome prevalence and its five individual components.ResultsMore regular behavioral-social rhythms were associated with lower odds of prevalent metabolic syndrome (SRM: odds ratio [OR] = 0.57, 95% confidence interval [CI] = 0.35–0.88; IV: OR = 4.00, 95% CI = 1.86–8.58; IS: OR = 0.42, 95% CI = 0.24–0.73) and two of its individual components: body mass index (SRM: OR = 0.56, 95% CI = 0.37–0.85; IV: OR = 2.84, 95% CI = 1.59–5.07; IS: OR = 0.42, 95% CI = 0.26–0.68) and high-density lipoprotein cholesterol (SRM: OR = 0.49, 95% CI = 0.30–0.80; IV: OR = 2.49, 95% CI = 1.25–4.96; IS: OR = 0.35, 95% CI = 0.19–0.66). Past shift work history did not moderate the association between behavioral-social rhythms and metabolic syndrome.ConclusionsBehavioral-social rhythms were related to CVD risk factors in retired adults regardless of prior night shift work exposure. Older retired workers may benefit from education and interventions aiming to increase behavioral-social rhythm regularity.
Seroprevalence of Herpes simplex virus Type-1 IgG antibodies among pregnant women with recurrent abortions
Authors: Ibrahim Hiba Siddig , Mohamed Dalal Abdelhamid , Ahmed Fatima , Hashim Hiba , Saeed Mohammed Ibrahim 
Published: April 2024

Herpes Simplex Virus Type 1 (HSV-1) is a nuclear replicating enveloped virus, usually acquired through direct contact with infected lesions or body fluids (typically saliva). The prevalence of HSV-1 infection increases progressively from childhood, and inversely related to socioeconomic background.
The infections among children are either asymptomatic or following an incubation period of about 1 week gives rise to mucocutaneous vesicular eruptions.
Herpetic gingivostomatitis typically affects the tongue, lips, gingival, buccal mucosa and the hard and soft palate.
The main aim of this study is to study the seroprevalence of herpes simplex virus type-1 IgG antibodies among pregnant women with recurrent abortions.
The study demonstrated a 29 (58%) were positive HSV-1-IgG and 21 (42%) were negative among cases (pregnant women) while 25 (100%) in control subject were negatives, and the possible risk factors i.e. age, Abortion, Blood transfusion, Contraceptive, Rash, have been examined in this study and showed no effect except previous history of TORCH test examination.,
The study concluded more than half pregnant women was found to be infected in our study, and we recommended to screen both IgM and IgG followed by viral detection and load by molecular technique in case of positive ELISA.