bluuebunny/crossref_metadata_2025_split huggingface dataset:
Matrine inhibits invasion and migration of gallbladder cancer via regulating the PI3K/AKT signaling pathway
Authors: Mo Rong-Liang , Li Zhuang , Zhang Peng , Sheng Ming-Hui , Han Gen-Cheng , Sun Deng-Qun 
Published: March 2024

Abstract
Gallbladder cancer (GBC) is a common malignant cancer in the biliary system, which poses a serious threat to human health. It is urgent to explore ideal drugs for the treatment of GBC. Matrine is the main active ingredient of sophora flavescentis, with a wide range of biological activities encompassing anti-inflammatory, antiviral, immunomodulatory and anti-tumor. However, the underlying mechanism by which Matrine treats GBC is still unclear. The purpose of this study is to investigate the anti-tumor effects of Matrine on GBC in vivo and in vitro, and to clarify the potential regulatory mechanisms. Here, in this primer, we found that Matrine has a significant killing effect on GBC through CCK8 and flow cytometry, including arrest of cell cycle, inhibition of GBC cell, and induction of apoptosis. Further studies in vivo confirmed that the inhibitory function of Matrine on tumor growth in NOZ xenografted nude mouse. At the same time, Matrine also significantly suppressed the migration and invasion of GBC cells through scratch and Transwell experiments. In addition, by detecting the mRNA and protein levels of epithelial-mesenchymal transition (EMT) and matrix metalloproteinases, Matrine furtherly substantiated the suppression of invasion and migration of GBC. From a mechanistic perspective, Matrine effectively decreased the abundance of p-PI3K and p-AKT protein in vivo and in vitro. More importantly, PI3K activator (740 Y-P) antagonized the anti-tumor effect of Matrine, while PI3K inhibitor (LY294002) increased the sensitivity of Matrine for GBC. Based on the above findings, we conclude that Matrine inhibits the invasion and migration of GBC by regulating PI3K/AKT signaling pathway. Our results indicate the crucial role and regulatory mechanism of Matrine in suppressing the growth of GBC, which provides a theoretical basis for Matrine to be a candidate drug for the treatment and research of GBC.
Multiperiod vaccination facility planning
Authors: Tacadao Grace , Simonis Helmut , Quesada Luis , O'Sullivan Barry 
Published: March 2024

Abstract
We propose a decision support tool, based on Mixed Integer Programming, to help with the planning of national vaccination campaigns, and test it on data and scenarios obtained from the publicly available information about the Irish COVID-19 vaccination program. We show that a large variety of constraints can be included in the tool, as well as combinations of different objective functions for the different stakeholders. The tests show that the multi-period/multi-vaccine problem can be effectively solved by the given model, while allowing to consider the impact of potential changes in the input data. We also present a number of specific visualizations that help the user understand the plan created by the application.
Magnitude of heterosis for economic traits in newly developed single hybrids of Silkworm, Bombyx mori L.
Authors: shinde Shriram Tukaram 
Published: March 2024

Abstract
An investigation was conducted in India using the parental stock breeds among the six bivoltine tester and five multivotine line strains of the silkworm Bombyx mori L., to estimate heterosis expressed in single cross hybrids with respect to important economic traits. In terms of mean value performance, testers CSR50 and GEN2, and line BL67, showed the most promise, while the F1 hybrid BL67 × GEN2 produced the highest shell weight, cocoon-shell percentage and maximum cocoon-filament weight. Other superior hybrids were BL24 × GEN2 for single cocoon weight, PM × GEN2 for cocoon filament length and HM × CSR17 for denier. For each trait in the hybrid combination, different heterotic effects were noted. Based on heterosis, hybrid BL67 × GEN2 was optimal for cocoon-shell ratio and single shell weight; PM × GEN2 for cocoon filament length and weight; PM × CSR16 for single cocoon weight; and BL24 × CSR5 for Denier. The majority of the hybrids outperformed the BL67 × CSR5 standard check variety. For all the characters studied collectively, no one hybrid outperforms the others. In general, the traits studied exhibited a greater degree of heterosis in their crosses. The overall analysis unequivocally demonstrates that future breeding programs will use the high-yielding lines and testers that were identified as potential breeds for the synthesis of superior multi × bivoltine hybrids for tropical conditions.
A critical discourse analysis of rejoinders to political press releases in selected Nigerian newspapers
Authors: JIDO ALIYU ABDULKAREEM 
Published: March 2024

Abstract
This paper presents a Critical Discourse Analysis of rejoinders to political press releases in selected Nigerian nnewspapers. The study examined the linguistic and discursive features, power relations and ideological positioning, and the contributions of rejoinders in shaping political narratives and public opinion. The analyses were based on Fairclough’s three dimensional approach to CDA.
The framework identified three approaches to CDA, namely: texts, discourse practice and sociocultural context. The approach pave way for systematic analysis of the data, and also help in arriving at the findings of the study. Data for the study comprises of ten (10) rejoinders from the selected Nigerian newspapers.
The selected Nigerian newspapers are: Punch Newspaper, Vanguard Newspaper, The Guardian Newspaper, The Blueprints Newspaper, TheCable Newspaper, DailyTrust Newspaper. Rejoinders analyzed are those from June 2022 to June 2023. Data were purposefully chosen on a specific genre of rejoinders to political press releases, such as statements from political parties, government officials, or opposition groups, providing a focused perspective. Furthermore, the criteria for selecting the sample of rejoinders, includes; relevance to political issues, diversity of perspectives, and prominence of the author.
This approach facilitates an in-depth exploration of linguistic features, power dynamics, and ideological positioning within political rejoinders.
The findings of this study reveals the strategic use of language in political rejoinders, covering vocabulary precision, power relations, ideological positioning, and rhetorical strategies.
In conclusion, this research contributes valuable insights to the field of CDA, emphasizing intertextuality, transparency, and accountability in political discourse. It serves as a valuable resource for academics and provides practical insights for enhancing political communication strategies.
First insight into the genomes of the Pulmonaria officinalis group (Boraginaceae) provided by repeatome analysis and comparative karyotyping
Authors: Kobrlová Lucie , Čížková Jana , Zoulová Veronika , Vejvodová Kateřina , Hřibová Eva 
Published: March 2024

Abstract

Background
The genus Pulmonaria (Boraginaceae) represents a taxonomically complex group of species in which morphological similarity contrasts with striking karyological variability. The presence of different numbers of chromosomes in the diploid state suggests multiple hybridization/polyploidization events followed by chromosome rearrangements (dysploidy). Unfortunately, the phylogenetic relationships and evolution of the genome, have not yet been elucidated. Our study focused on the P. officinalis group, the most widespread species complex, which includes two morphologically similar species that differ in chromosome number, i.e. P. obscura (2n = 14) and P. officinalis (2n = 16). Ornamental cultivars, morphologically similar to P. officinalis (garden escapes), whose origin is unclear, were also studied. Here, we present a pilot study on genome size and repeatome dynamics of these closely related species in order to gain new information on their genome and chromosome structure.
Results
Flow cytometry confirmed a significant difference in genome size between P. obscura and P. officinalis, corresponding to the number of chromosomes. Genome-wide repeatome analysis performed on partial Illumina sequencing data showed that retrotransposons were the most abundant repeat type, with a higher proportion of Ty3/Gypsy elements, mainly represented by the Tekay lineage. Comparative analysis revealed no species-specific retrotransposons or striking differences in their copy number between the species. A new set of chromosome-specific cytogenetic landmarks, represented by satellite DNAs, showed that the chromosome structure in P. officinalis was more variable compared to that of P. obscura. Comparative karyotyping strongly supported the hybrid origin of putative hybrids with 2n = 15 collected from a mixed population of both species and outlined the origin of ornamental garden escapes, confirming their derivation from the P. officinalis complex.
Conclusions
Large-scale genome size analysis and repeatome characterization of the two morphologically similar species of the P. officinalis group improved our knowledge of the genome dynamics and differences in the karyotype structure. A new set of chromosome-specific cytogenetic landmarks was identified and used to reveal the origin of putative hybrids and ornamental cultivars morphologically similar to P. officinalis.
MEWUJUDKAN PARTAI POLITIK YANG DEMOKRATIS MELALUI SISTEM PRIMARY ELECTIONS DI INDONESIA
Authors: Oktasari Frenty , Razzak Abdul , Liza Fransisca Bella 
Published: March 2024

Di Negara Indonesia pemilihan calon presiden dan wakil presiden yang terdapat pada Partai Politik terlihat kurang sistematis dan demokratis. Dimana pengambilan keputusan hanya berdasar kepada ketua umum partai politik saja. Sehingga menyebabkan calon presiden dan wakil presiden yang dipilih ketua umum partaiv, sering kali tidak sesuai kehendak dan terkesan konstituen. Terdapat beberapa Partai Politik yang mengelola hal tersebut dalam anggaran dasar, akan tetapi ketentuan yang dimaksud tidak mampu melakukanya dengan maksimal yang di sebabkan karena adannya peraturan presidential threshold yang memakssa setiap partai untuk berkoalisi untuk mencalonkan sebagai presiden dan wakil presiden. Yang mana problem tersebut mampu di atasi karena adanya pengaplikasian primary elections seperti yang pernah dilakukan oleh negara-negara demokratis seperti negara Amerika Serikat dan juga negara Prancis. Tujuan dari jurnal penelitian ini untuk mengasumsikan pengaplikasian primary elections di Negara Indonesia dalam mewujudkan Partai Politik yang demokratis. Dalam penelitia ini, artikel yang digunakan di ambil dari sumber-sumber yang relevaan untuk menjelaskan argumentasi penting terkait dengan pengaplikasian primary elections di negara Indonesia. Selain itu artikel juga menggunakan studi komparasi dengan negara Perancis dan negara Amerika Serikat sebagai negara yang telah menerapkan primary elections. Dengan melihat urgensi menerapkan primary elections sangat perlu diterapkan di negara Indonesia ini. Karena searah dengan tujuan dari regulasi, yang mana sebagai salah satu upaya agar terwujudnya perlembagaan Partai Politik yang demokratis dengan mekanisme yang di ambil pada pemilihan calon presiden dan calon wakil presiden yang dipilih langsung oleh pemilih.
Multicomponent 3D-printed Collagen-based Scaffolds for Cartilage Regeneration:
Recent Progress, Developments, and Emerging Technologies
Authors: Mikaeeli Kangarshahi Babak , Naghib Seyed Morteza 
Published: March 2024

Abstract:
Cartilage tissue presents challenges in terms of repair and regeneration due to its inherent limitations in self-healing and the scarcity of available donors. Cartilage damage can result in the development of joint problems characterized by symptoms, such as pain, swelling, and osteoarthritis. Collagen scaffolds are extensively used as biomimetic substances for cartilage engineering due to their ability to offer structural, biochemical, and mechanical signals for chondrocytes. Nevertheless, traditional techniques for producing collagen scaffolds frequently yield inadequate pore architecture, diminished mechanical robustness, and restricted form accuracy. Hence, 3D printing is a developing method that can surpass these restrictions by allowing accurate manipulation of the shape, porousness, and makeup of the scaffold. 3D printing has the capability to include various materials and cells in the scaffolds, resulting in the production of intricate and personalized tissue structures. This research examines the latest progress in utilizing 3D printing to create collagen scaffolds for the purpose of regenerating cartilage. This text discusses the different sources of collagen, methods of cross-linking, techniques for printing, and strategies for post-processing that are employed to improve the performance of scaffolds. Furthermore, it discusses the difficulties and potential future paths of utilizing 3D printing to create collagen scaffolds for the purpose of regenerating cartilage.
Trends in the Synthesis of Antimicrobial Derivatives by using the Gewald,
Strecker, and Groebke-Blackburn-Bienaymé (GBB) Reactions
Authors: Naithani Kaushal , Bhowmik Subhendu 
Published: March 2024

Background:
Multicomponent reactions are highly useful in synthesizing natural products
and bioactive molecules. Out of several MCRs, although utilized widely, some remain neglected
in review articles. The Gewald and Groebke-Blackburn-Bienaymé (GBB) reactions are two such
reactions. This comprehensive review assimilates applications of Gewald and Groebke-Blackburn-
Bienayme reactions in synthesizing novel antimicrobial agents. It presents the antimicrobial properties
of the synthesized molecules, providing an overview of their potential druggability.

Objective:
Developing novel antimicrobial agents is the need of the hour. Toward this objective,
the scientific community is developing new methods for constructing novel architectures with potential
antimicrobial properties. This review will showcase the usefulness of the Gewald, Strecker,
and Groebke-Blackburn-Bienaymé (GBB) reactions in synthesizing antimicrobial molecules.

Methods:
The articles are searched by using the Sci-finder search tool and summarize the chemistry
of their synthesis and antimicrobial evaluation of the molecules

Results:
This review focuses on synthesizing antimicrobial molecules using the Gewald, Strecker,
and Groebke-Blackburn-Bienaymé (GBB) reactions. The antimicrobial activities of the synthesized
molecules are also summarized in tables.

Conclusion:
This review will briefly overview the application of the Gewald, Strecker, and Groebke-
Blackburn-Bienaymé (GBB) reactions in synthesizing novel antimicrobial molecules. It contains
several molecules with promising activity against resistant and non-resistant microbial strains. These
promising molecules could be studied further to develop novel antibiotics.
Comparison of the Efficacy of Oral Magnesium with Oral Ketorolac for Postoperative Pain Management in Anorectal Surgery: A Double-blinded
Randomized Clinical Trial
Authors: Eshagh Hoseini Seyed Jalal , Ghazi Farzanesadat , Eshraghi Mohsen , Vahedian Mostafa , Pashaei Mohammad Reza , Habibi Mohamad Amin , Ahmadpour Sajjad 
Published: March 2024

Background:
Due to the presence of postoperative pain in patients undergoing anorectal
surgery, and since the pain affects the quality of life of patients, we aimed to compare the analgesic
effectiveness of oral magnesium with oral ketorolac to choose the right analgesic drug for these
patients.

Methods:
This study was a double-blind, randomized clinical trial performed on 104 candidates
undergoing anorectal surgery. Patients were randomly divided into two groups. Group 1 received
oral magnesium (250 mg daily), and group 2 received oral ketorolac (10 mg daily). The medicine
was given to the patient 2 hours after the operation and every 12 hours for 10 days. Pain measurements
were recorded at 24-hour intervals after surgery based on the visual analog scale and numerical
rating scale.

Results:
This study found that postoperative pain was reduced in patients taking magnesium
tablets, similar to the ketorolac group. A similar decreasing trend was observed in the group receiving
ketorolac; however, the reduction was more pronounced in the magnesium group and was statistically
significant on days 1, 3, and 5 (p < 0.001). However, insignificant differences were noted
between the two groups on the seventh (p = 0.093) and tenth (p = 0.088) postoperative days.

Conclusion:
Taking magnesium tablets after surgery has a suitable analgesic effect, which is similar
to oral ketorolac tablets from the fifth day onwards, but in the initial days, it is less effective
than ketorolac statistically.
Premenstrual Syndrome Based On Physical Activity, Body Mass Index And Blood Pressure In Adolescent Girls
Authors: Nisa Juhrotun , Hidayah Seventina Nurul , Izzah Nur Syifa Karomatul 
Published: March 2024

Background: One of the risk factors for PMS is physical activity, where during the COVID-19 pandemic there was a decrease in physical activity with PPKM. The impact of this decrease in physical activity is an increase in BMI. Obese women are more than twice as likely to have PMS, and obesity can also increase blood pressureObjective: to determine the relationship between physical activity, BMI and blood pressure with the incidence of PMS in adolescent girls.Method: This research is a cross sectional study. The population is young women in SMA N 1 Pagerbarang. With a total sample 212 people and the sampling technique uses quota sampling. Data collection by questionnaire and atropometric measurements of weight and height. Data analysis using chi square.Results and Discussion: A total of 45.8% of respondents experienced PMS. 46.7% had light physical activity, 54.7% had normal BMI and 87.3% had normal blood pressure 87.3%. Test the relationship between PMS with physical activity obtained P = 0.001, PMS with BMI with P = 0.005, and PMS with Blood Pressure with P value = 0.524.Conclusion: there is a relationship between physical activity and BMI with PMS, but there is no relationship between PMS with blood pressure. Keywords: PMS; Physical Activity; BMI; Blood Pressure.
PENGARUH KOMPETENSI SDM, PEMANFAATAN TI,DAN PENGENDALIAN INTERN TERHADAP KUALITAS LAPORAN KEUANGAN
Authors: Cahyani Ni Made Dita , Sastri Ida I Dewa Ayu Manik , Yudha Cokorda Krisna 
Published: March 2024

Penelitian ini berjudul Pengaruh Kompetensi Sumber Daya Manusia, Pemanfaatan Teknologi Informasi, dan Pengendalian Intern Terhadap Kualitas Laporan Keuangan Pada BPR di Ubud. Permasalahan yang dikaji dalam penelitian ini adalah apakah pengaruh kompetensi sumber daya manusia, pemanfaatan teknologi informasi, dan pengendalian intern secara parsial terhadap kualitas laporan keuangan pada BPR di Ubud. Penelitian ini bertujuan untuk untuk mengetahui kompetensi sumber daya manusia, pemanfaatan teknologi informasi, dan pengendalian intern secara parsial terhadap kualitas laporan keuangan pada BPR di Ubud. Populasi pada penelitian ini adalah seluruh pegawai dari 6 Bank Perkreditan Rakyat di Ubud. Metode penentuan sampel yang digunakan dalam penelitian ini adalah purposive sampling, sampel pada penelitian ini adalah 47 responden. Pengumpulan data primer dilakukan dengan menggunakan kuesioner. Teknik analisis data yang digunakan yaitu regresi linear berganda. Hasil penelitian ini terdapat pengaruh positif dan signifikan secara parsial dari kompetensi sumber daya manusia, pemanfaatan teknologi informasi, dan pengendalian intern secara parsial terhadap kualitas laporan keuangan pada BPR di Ubud.
SUSTAINABILITY BANK PERKREDITAN RAKYAT DENGAN KINERJA SISTEM INFORMASI AKUNTANSI KEBERLANJUTAN
Authors: Purnama Sri , Wasita Putu Aristya Adi , Ardana I Made Dwi Wira 
Published: March 2024

This study aims to examine the development of a sustainability accounting information system based on contingency theory. In today's digital era, BPRs face many data sets, including financial and non-financial data. However, empirical evidence is still scarce on how sustainability issues are linked or integrated into the company's internal information system. The initial data used in this study came from 80 respondents from BPRs in Badung Regency. The results show that there is a significant relationship between stakeholder engagement, especially internal stakeholders, and sustainability accounting information systems; most of the surveyed BPRs include sustainability strategies as core BPR strategies; however, there is no relationship between sustainability accounting information systems and BPR strategies, and firm size does not moderate sustainability accounting information systems with BPR strategies. The limitation of this study relates to the small sample size, which only uses respondents from BPRs in Badung Regency. The results of this study are important to encourage the social responsibility of BPRs by developing a sustainability accounting information system.
O humor na imprensa periódica portuguesa (1797-1835)
Authors: Ferreira João 
Published: March 2024

Este artigo aborda os processos humorísticos na formação do Portugal contemporâneo. Indaga o papel do humor na construção da opinião pública e pretende compreender o seu lugar no modo como se desenvolveu a comunicação impressa em Portugal no período de transição do Antigo Regime para o Estado liberal e também entender o peso das contradições que o humor revela, seja no plano social seja no político.
Desafios para ensinar a pensar historicamente
Authors: Barca Isabel 
Published: March 2024

Resumo: Na linha de pesquisa de educação histórica, este estudo toma a natureza genuína do conhecimento histórico, combinada com princípios da cognição contextualizada, como pressuposto crucial para aprender a pensar historicamente. Discute de que forma essa linha de pesquisa tem explorado as ideias de crianças e jovens quando prestam atenção à evidência e comparam perspectivas para construir uma compreensão significativa do passado, de forma a encontrar (uma melhor) orientação temporal na sua vida em sociedade. Este trabalho seleciona e interpreta alguns exemplos dos modos pelos quais quatro elementos fundamentais de estudos empíricos (questões de pesquisa, alunos participantes e seus contextos, tarefas dos alunos, análise dos dados e resultados) estão entrelaçados nessa área. De acordo com esta ideia, são apresentadas algumas sugestões sobre uma possível, embora sempre por tentativa, relação efetiva entre epistemologia, pesquisa empírica e práticas de ensino e aprendizagem. Palavras-chave: Educação histórica; Teoria da história; Práticas científicas e escolares. Abstract: In the line of research in history education, this study takes the genuine nature of historical knowledge, combined with principles of contextualized cognition, as a crucial presupposition for learning to think historically. It discusses how this line of research has explored the ideas of children and young people when they pay attention to the evidence and compare perspectives to build a meaningful understanding of the past, in order to find (a better) temporal orientation in their life in society. This work selects and interprets some examples of the ways in which four fundamental elements of empirical studies (research questions, participating students and their contexts, student tasks, data analysis and results) are intertwined in this area. In accordance with this idea, some suggestions are made about a possible, albeit tentative, effective relationship between epistemology, empirical research and teaching and learning practices. Keywords: History education; Theory of history; Scientific and school practices.