bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of fine‐needle aspiration biopsy in the assessment of renal masses
Authors: Cristallini Enrico G. , Paganelli Cristina , Bolis Giovanni B. 
Published: February 2007

AbstractClinical and histological control of fine‐needle aspiration biopsy (FNAB) diagnosis of 72 kidney masses observed between 1981 and 1988 confirmed 34 benign and 33 malignant lesions, but did not confirm four malignant and one benign lesions, giving a total diagnostic accuracy of 93.05%. The role of FNAB in selecting cases to be sent to surgery was investigated by comparing the incidence of useful surgery (for benign and primary malignant neoplasias) and the incidence of useless surgery (for nonneoplastic lesions and secondary malignant neoplasias) in nephrectomized patients who either had (group A, 27 patients) or didn't have (group B, 198 patients) preoperative FNAB. The differences were highly significant (P < 0.001). Furthermore, patients operated for malignant neoplasias (20 in group A; 117 in group B) displayed highly significant differences (P < 0.001) with respect to renal vein infiltration (1 in group A versus 22 in group B) and local‐ regional lymph node metastases (1 in group A versus 15 in group B). In conclusion, FNAB is a reliable method for selecting cases for surgery and for aiding in the diagnosis of malignant neoplasias.
Fine‐needle aspiration biopsy diagnosis of malignant rhabdoid tumor of the kidney
Authors: Akhtar Mohammed , Ali Muhammad Ashraf , Sackey Kwesi , Bakry Mohammed , Burgess Anwar 
Published: February 2007

AbstractA series of six fine‐needle aspiration biopsies from three patients with malignant rhabdoid tumor of the kidney is reviewed. The smears revealed round, polygonal, and irregularly shaped cells with large nuclei and prominent nucleoli. Some of the tumor cells contained light pink to purple cytoplasmic inclusions that correlated with the eosinophilic inclusions seen in histopathologic sections and filamentous cytoplasmic aggregates noted on ultrastructural examination. Diagnosis of malignant rhabdoid tumor of the kidney may be suggested from aspiration biopsy smears; however, further confirmation of the diagnosis by histologic or ultrastructural examination is desirable.
Fine‐needle aspiration cytology of papillary hürthle‐cell tumors of thyroid: A report of three cases
Authors: Chen Karl T. K. 
Published: February 2007

AbstractPapillary Hürthle‐cell tumors of the thyroid are composed of oxyphilic cells with a prominent papillary component. Their biologic behavior appears to be comparable with that of conventional papillary thyroid carcinomas. The literature on the fine‐needle aspiration cytology of these tumors is scanty. The cytologic findings of three such cases are reported here. The findings suggest that most papillary Hürthle‐cell tumors cannot be differentiated from other types of Hürthle‐cell tumors cytologically.
Carcinoma of the breast in a fibroadenoma: Diagnosis by fine‐needle aspiration cytology
Authors: Gupta Raj K. , Simpson John 
Published: February 2007

AbstractA case of carcinoma of the breast concurrent with a fibroadenoma in a 49‐yr‐old female is described in which the diagnosis was made on fine‐needle aspiration cytology. Reports of such an occurrence are few, and to our knowledge none has previously documented the cytologic findings in detail.
Anaplastic thyroid carcinoma: Cytomorphology and clinical implications of fine‐needle aspiration
Authors: Guarda Luis A. , Peterson C. Eric , Hall William , Baskin H. Jack 
Published: February 2007

AbstractFour cases of anaplastic carcinoma of the thyroid were diagnosed in 1.519 thyroid aspirates. All patients had unilateral or diffuse nodular enlargement of the thyroid. One patient had a concurrent grade 1 mucinous carcinoma of the ovary. Cytologically, the neoplasms were characterized by pleomorphic giant or spindle cells with multilobulated, single or multiple nuclei. The chromatin pattern was clumped with prominent parachromatin clearing, and there were multiple prominent nucleoli. Associated papillary and follicular structures were recognized in two aspirates. All cytologic preparations were considered diagnostic of malignancy. Examination of histologic material revealed the same elements identified cytologically on the aspiration smears. Three patients died shortly after diagnosis due to massive local tumor growth in the neck. One patient, who received radiation therapy, had a prolonged survival of 30 mo, but died then of local neck recurrence. The cytologic features of anaplastic carcinoma parallel their histologic appearance. Histologic confirmation of cytologically diagnosed anaplastic carcinoma is not necessary.
Fine‐needle aspiration of gastric leiomyoblastoma metastatic to the subcutis
Authors: Kung I. T. M. , Yuen R. W. S. , Hwang S. T. 
Published: February 2007

AbstractLeiomyoblastomas are rare tumors, and there have been few reports on their fine‐needle aspiration (FNA)cytologic morphology. We herein describe the FNA features of a gastric leiomyoblastoma with subcutaneous metastasis. The cells had eosinophilic cytoplasm and oval eccentric nuclei, occasionally with intranuclear cytoplasmic inclusions. An organoid pattern was obvious in cell block sections. The tumor was positive for vimentin but negative for desmin, S‐100 protein, and the common epithelial markers. The histogenesis is discussed, as are reasons why this tumor is better termed epithelioid mesenchymal tumor.
Fine‐needle aspiration cytology of tubular carcinoma of the breast in a young woman
Authors: Gupta Raj K. , Dowle Carl 
Published: February 2007

AbstractThe fine‐needle aspiration cytology (FNAC) findings in a case of rare tubular carcinoma of the breast in a young woman are presented. The rarity of occurrence of tubular carcinoma in the breast and the bland and mostly orderly appearance of cells in the FNAC sample, as in tissue, were considered to cause the dificulty in the diagnosis of this tumor; also, these were features also found in other conditions of the breast. Furthermore, cytologists have limited experience with the diagnosis of this neoplasm from FNAC samples. It is therefore felt that (I) a cautious attitude is necessary when commenting on FNAC samples until more specific criteria are forthcoming for the diagnosis of this neoplasm: and (2) if cellular atypias are seen in FNAC samples, these should be reported with a recommendation for removal of the breast lump and a detailed tissue examination.
Transmucosal endoscopic needle aspiration: Utility in the diagnosis of extrinsic malignant masses of the gastrointestinal tract
Authors: Abdul‐Karim Fadi W. , O'Mailia James J. , Wang Ko Pen , Deeds David A. , Yang Peter 
Published: February 2007

AbstractTransmucosal endoscopic needle aspiration established the diagnosis in three patients with extrinsic malignant compression of the GI tract. The technique had not been applied previously to the diagnosis of such lesions. Our initial experience shows it to be a safe and effective method.
Adenocarcinomas in the cervicovaginal papanicolaou smear: Analysis of a 12‐year experience
Authors: Kim Han‐Seob , Underwood Diane 
Published: February 2007

AbstractWe attempted to reassess the significance of cervicovaginal Papanicolaou smear(s) in identifying adenocarcinoma (AC) by comparing Papanicolaou smears with histopathology in a pool of 188 patients. The first part of study dealt with 95 patients, seen over a 12‐yr period (1975–1986), who had tissue diagnosis of cervical or endometrial AC, all with prior Papanicolaou smears available. Of the 95 patients, Papanicolaou smears were positive and/or inconclusive for uterine AC in 37 (38.9%) and falsely negative in 58 (61.1%) patients. Of the latter, six were either positive and/or inconclusive for squamous carcinoma and moderate to severe dysplasia; thus, the effective detection rate (sensitivity) for malignancy and related condition of Papanicolaou smears was 45.3% (43 of 95). The second part of the study concerned the analysis of 130 patients with 148 Papanicolaou smear in whom cytologic diagnosis positive and/or inconclusive for AC was made during the same study period, Tissue diagnoses were available in 107 of these as follows: AC and glandular hyperplasia in 66 patients (61.7% predictive value), with 11 (10.3%) from extrauterine sources; squamous carcinoma in 12 and moderate to severe dysplasia in 5, totalling 17 patients (15.9%); miscellaneous conditions (polyps, radiation change, and glandular atrophy) in 11 patients (10.3%); and no pathologic change in 13 patients (12.1%). The effective predictive value of positive and/or inconclusive Papanicolaou smears for all malignancy and related states is 77.6%.
Role of testicular fine‐needle aspiration biopsy in the evaluation of male infertility: Cytologic and histologic correlation
Authors: Ali Muhammad Ashraf , Akhtar Mohammed , Woodhouse Nicholas , Burgess Anwaar , Faulkner Carol , Huq Mahmuda 
Published: February 2007

AbstractA series of testicular fine‐needle aspiration biopsy specimens from 272 infertile men with azoospermia were reviewed and categorized according to morphologic patterns. These included active spermatogenesis, 14 (5%); hypospermatogenesis, 106 (39%); Sertoli cells only, 70 (26%); atrophic pattern, 52 (19%); and maturation arrest, 1 (0.36%). In 29 cases (11%) the amount of material was insufficient for evaluation. The histologic and cytologic findings in 52 cases showing spermatogenesis correlated very well in 52 cases for which open testicular biopsy specimens were also available. These findings indicate that fine‐needle aspiration biopsy of the testis is a reliable and useful technique for the investigation of patients with azospermia.
Fine‐needle aspiration biopsy of orbital and periorbital masses
Authors: Glasgow Ben J. , Layfield Lester J. 
Published: February 2007

AbstractWe present the cytologic findings of 18 fine‐needle aspirates performed on orbital and periorbital masses. An accurate specific diagnosis was confirmed by histology in ten cases. In eight cases the diagnostic evaluation and/or therapeutic regimen was significantly altered by the results of the fine‐needle biopsy. In three cases the cytologic diagnoses obviated the need for open biopsy. Two specimens were insufficient for diagnosis. No false positive diagnoses of malignancy occurred. Electron microscopy was useful in three cases to confirm the correct cytologic diagnosis. Immunocytochemistry helped to define a lymphoid proliferation as monoclonal. The cytologic findings from an unusual case of sebaceous carcinoma are presented.
Sensitivity of fine‐needle aspiration biopsy in the detection of mycobacterial infections
Authors: Qadri S. M. Hussain , Akhtar Mohammed , Ali Muhammad Ashraf 
Published: February 2007

AbstractA series of 290 fine needle aspiration biopsies (FNABs) processed for mycobacterial cultures are reviewed. The clinicopathologic features in 162 cases were suggestive of tuberculous infection and 86 (53%) of the samples in these cases were culture positive. A comparative histologic and cytologic correlation was carried out in 23 cases. Aspiration smears from caseating granulomas were composed of necrotic debris containing large numbers of polymorphonuclear cells and scattered histiocytes, epithelioid cells, and multinucleated giant cells. In cases of noncaseating granulomas, the smears revealed well‐defined aggregates of epithelioid cells without necrotic debris or significant numbers of other inflammatory cells. There was a close correlation between the histologic and cytologic diagnosis of caseating and/or noncaseating granulomalous inflammation.
Thyrolipoma: Diagnostic pitfalls in the cytologic diagnosis and review of the literature
Authors: Rollins Susan D. , Flinner Robert L. 
Published: February 2007

AbstractThyrolipoma, or adenolipoma of the thyroid gland, is an uncommon neoplasm and thus not recognized by many cytopathologists. This is the first article to describe the fine‐needle aspirate findings of a histologically confirmed thyrolipoma. The gross morphologic and computerized tomographic features of this entity are also discussed, and the literature is reviewed.
Goblet‐cell carcinoid tumor in peritoneal fluid: A case report
Authors: Wojcik Eva M. , Selvaggi Suzanne M. 
Published: February 2007

AbstractAn unusual case of goblet‐cell carcinoid in the peritoneal fluid of a 49‐yr‐old woman with a prior history of carcinoid tumor of the appendix is presented and discussed. Cytologic findings included clusters of uniform small cells containing nuclei with finely granular chromatin, small prominent nucleoli, and scant cytoplasm admixed with signet‐ring cells. Peritoneal biopsies contained acini and small glands lined by malignant cells with features of a carcinoid tumor. Prominent signet‐ring cells were interspersed within tumor nests. The signet‐ring cells and small glandular lumens showed strong mucin positivity. Endocrine tumor cells were argyrophil‐ and argentaffin‐positive. The histologic findings confirmed the diagnosis of goblet‐cell carcinoid involving peritoneal fluid.
HIV infection‐associated lymphoepithelial lesions of the parotid gland: Aspiration biopsy cytology, histology, and pathogenesis
Authors: Tao Liang‐Che , Gullane Patrick J. 
Published: February 2007

AbstractTwo homosexual men with parotid swellings were shown to be human immunodeficiency virus (HIV)‐positive. They initially presented with a painless solitary parotid mass accompanied by diffuse cervical lymphadenopathy. In case I, the patient further developed bilateral multiple cystic lesions. Aspirate preparations from the cystic lesions contained numerous anucleate squames, and superficial and intermediate squamous cells intermingled with various follicular center cells and lymphocytes. Immunoblasts and active phagocytosis of nuclear debris were also noted. Histologically, the parotid cystic lesions showed squamous epithelium‐lined clefts surrounded by abundant hyperplastic lymphoid tissue with prominent germinal centers. The cystic lesions did not involve submandibular and sublingual glands. The combination of bilateral multiple lymphoepithelial lesions of the parotid glands and diffuse cervical lymphadenopathy represents a new condition in patients who are likely to be HIV‐positive. At the early stage of the disease, when the lesion is confined to a unilateral parotid gland, the cytologic findings of the parotid mass, in combination with a computed tomographic appearance of multiple cystic lesions, are distinctly different from findings in other neck and facial lesions. The patient should be tested for antibodies to the HIV virus to confirm this diagnosis, so that the appropriate precautions and treatment can be initiated.
Malignant lymphoma of the thyroid: A report of two cases diagnosed by fine‐needle aspiration
Authors: Detweiler Rosemary E. , Katz Ruth L. , Alapat Christina , El‐Naggar Adel , Ordóñez Nelson 
Published: February 2007

AbstractTwo cases of primary malignant lymphoma of the thyroid were diagnosed by fine‐needle aspiration biopsy. In addition to morphologic evaluation performed on direct smears, immunophenotyping, flow cytometry, and molecular studies were performed on the aspirated material. These additional studies made a clear distinction between lymphoma and Hashimoto's thyroiditis, which may present a similar cytologic picture.
Extrarenal primitive malignant tumor with rhabdoid features: Fine‐needle aspiration cytology, lmmunocytochemistry, and electron microscopy of a case
Authors: Pettinato Guido , Manivel J. Carlos , d'Amore Emanuele S. G. , Petrella Giuseppe 
Published: February 2007

AbstractWe describe a malignant pelvic tumor with rhabdoid‐like features that arose in the sacroiliac region of a 15‐year‐old girl. Fine‐needle aspiration (FNA) cytology showed large cells with glassy cytoplasm, globular hyaline cytoplasmic inclusions, and prominent nucleoli. Immunocytochemical methods applied to FNA material revealed immunoreactivity for cytokeratin, epithelial membrane antigen, and vimentin; the cellsfailed to react with antibodies to desmin. This distinct appearance and phenotype was most consistent with a diagnosis of extrarenal malignant rhabdoid tumor. Electron microscopy confirmed this interpretation, showing whorled Jlamentous aggregates in the cytoplasm of the tumor cells.
Fine‐needle aspiration cytology of a metastatic merkel‐cell carcinoma
Authors: Al‐Kaisi Nadia K. 
Published: February 2007

AbstractThe cytologic features of Merkel‐cell carcinoma metastatic to inguinal lymph nodes are described. The primary tumor was in the buttocks. The cytologic smears from the inguinal lymph node were highly cellular, with small to medium‐sized cells in a predominantly discohesive or single‐cell pattern, as well as large clusters surrounding segments of capillary‐sized blood vessels. The nuclei were uniform, round to oval, with delicate nuclear membranes. The chromatin pattern was fine and “powdery” with multiple small micronucleoli. The cytoplasm was very scanty. Intermediate filament “buttons” were abundant. Rosette formation was very rare. Frequent mitotic figures and individual cell necrosis were observed. These features are helpful in the differential diagnosis from other small‐cell tumors that may involve the skin.
Fine‐needle aspiration cytology of ovarian follicle cysts with cellular atypia from reproductive‐age patients
Authors: Selvaggi Suzanne M. 
Published: February 2007

AbstractThe cytologic features of four luteinized ovarian follicle cysts with cellular atypia, obtained by fine‐needle aspiration, are presented and discussed. The threepatients, ages 31, 32, and 34, underwent laparoscopy for workup of unilateral or bilateral ovarian cysts. In each case, the aspirates were cellular and composed of atypical cells arranged in glandular clusters and papillary configurations. The cells showed an increased nuclear/cytoplasmic ratio and contained nuclei with prominent chromocenters, granular chromatin, and prominent nucleoli, some irregular in shape. Cell borders were indistinct, and the cytoplasm was finely vacuolated. In each case, the smears were interpreted by the cytotechnologist as showing cellular features compatible with malignancy. In addition to the atypical cells, the cytopathologist noted a few sheets of well‐ preserved small granulosa cells. A thorough review of the clinical histories revealed the patients to be 8, 6, and 6 mo postpartum, respectively, at the time of needle aspiration. In conjunction with the clinical histories, the cytologic findings supported a diagnosis of follicle cysts containing atypical luteinized granulosa cells. It is postulated that hormonal stimulation may have played a role in the development of the cellular atypiapresent within the luteinized cells. When analyzing ovarian cyst fluid from reproductive‐age patients, this entity should be considered so as not to make an erroneous diagnosis of malignancy.
Papillary renal‐cell carcinoma: Fine‐needle aspiration of 15 cases
Authors: Dekmezian R. , Sneige N. , Shabb N. 
Published: February 2007

AbstractAlthough papillary carcinoma of the kidney is a distinct clinical and pathological entity, there are few descriptions of its cytologic features in the literature. We describe the cytologic features of aspirates from 1.5 papillary carcinomas of the kidney. The smears showed abundant papillary clusters with vascular cores and relatively few single cells. Tumor cells contained moderate to scant cytoplasm, nuclei were usually small and uniform, mild to moderate hyperchromasia was routine, nucleoli were single and small, and nuclear grooves were often prominent. Histiocytes and psammoma bodies were present in only four cases. Hemosiderin pigment within tumor cells was also present in four cases. Differential diagnosis should consider low‐grade transitional‐cell carcinoma, metastatic adenocarcinoma, normal renal tubular epithelium, mesothelial cells, and, occasionally, Wilms' tumor. Cytologically recognizing the distinct entity of papillary carcinoma is important in the workup of primary renal neoplasms and metastatic papillary neoplasms of unknown origin.
Diagnosis of cytomegalovirus pneumonitis on bronchoalveolar lavage fluid: Comparison of cytology, immunofluorescence, and in situ hybridization with viral isolation
Authors: Weiss Ronald L. , Snow Gail W. , Schumann G. Berry , Hammond M. Elizabeth 
Published: February 2007

AbstractForty‐three bronchoalveolar lavage (BAL) specimens from 40 immunocompromised patients were studied for the presence of cytomegalovirus (CMV) by rapid diagnostic methods. DNA in situ hybridization, cytology, and immunofluorescence were compared to conventional cell culture. Eleven (25%) of the 43 BAL samples grew CMV in culture. In situ hybridization detected 6 of these 11 for sensitivity, specificity, and predictive values of positive and negative of 55%, 94%, 75%, and 86%, respectively. Cytology had a sensitivity of 73% and specificity of 100%. Six Papanicolaoustained cytospins were screened cytologically versus one hybridization cytospin, and the higher sensitivity of cytology may reflect this extensive sampling. The immunofluorescent method had a sensitivity equal to that of cytology (73%); however, the specificity (72%) was significantly less than that of either the probe or cytology. These data suggest that although in situ hybridization can be a rapid, useful method for detecting CMV in BAL specimens, cytology appears to be a more sensitive method.
Intracytoplasmic vacuoles in cervical smears: Relationship to chlamydial inclusions–morphology, mucin histochemistry, and immunocytochemistry
Authors: Waters Susan A. , Sterrett Gregory F. 
Published: February 2007

AbstractCytomorphology, mucin stains, and immunocytochemistry were used to determine the characteristics of intracytoplasmic vacuoles in cervical smears and their relationship to chlamydial infections. Three study groups were examined: A) cervical smears containing intracytoplasmic vacuoles suggesting chlamydial infection; B) cervical smears from patients known to be either culture positive or culture negative for chlamydia; and C) control smears of chlamydia‐infected McCoy cell cultures. Forty‐nine smears containing vacuoles suspected of being chlamydial inclusions were studied. In 21 of 31 smears the vacuoles were shown by histochemistry to contain mucin. Immunoperoxidase staining performed on the remaining 18 smears revealed only two vacuoles to be chlamydial inclusions. Of 38 smears from chlamydia‐culture‐positive patients, only 4 showed chlamydial inclusions by immunoperoxidase methods. Of 30 smears from chlamydia‐culture‐negative patients, none were positive by immunoperoxidase staining. The “nebular body” of Shiina appears to be the most specific cytomorphologic evidence of chlamydial infection in cervical smears, but distinction from mucin vacuoles and other nonspecific vacuoles is difficult. The immunoperoxidase technique is unlikely to be useful in diagnosis in cervical smears unless samples are specifically obtained from the endocervical canal by endocervical brushing.