bluuebunny/crossref_metadata_2025_split huggingface dataset:
GEYSERNAYA RIVER ALLUVIUM (KAMCHATKA): COMPOSITION AND FEATURES OF FORMATION<a href="#FN2"><sup>2</sup></a>
Authors: Lebedeva E. V. , Zakharov A. L. , Mikhalev D. V. 
Published: April 2024

A comprehensive compositional analysis of the alluvium from the river with active gas-hydrothermal manifestations was carried out for the first time. Geysernaya river alluvium is characterized by: poor roundness of boulders and pebbles (grades 1–2), poorly sorted fine-clastic component, abundance of rock fragments and intergrown minerals even in the fine sand fraction. All these indicate the sediment weak disintegration with significant amount of slope material in it, including redeposited by mudflows. The high content of smectite-zeolite and other newly formed (secondary) minerals aggregates (up to 70% of the light fraction 0.1–0.25 mm in size) and altered rock fragments (up to 70–80% in the pebble fraction of alluvium) indicate that a gas-hydrothermal activity significantly impact the bedrock and alluvium weathering within the thermal fields. The material accumulates predominant in the areas of: (1) active delivery of slope material (temporary dams), (2) the longitudinal profile flattening in dammed reservoirs, and (3) mudflow material removal. Formation of two dammed reservoirs over the past 15 years, as well as layers of fine sand found in the low terrace’s sediments, indicate that such short-lived basins form periodically in the Geysernaya river valley. The conditions of the fine sand deposition in sections of a single-branch channel and within dammed reservoirs are differ, which affects the heavy fraction leading minerals ratio. The well-rounded gravel and abundance of coarse sand, and their decrepit appearance indicates that, along with the processing of incoming slope and mudflow material large volumes the Geyzernaya river continues to cut in and erodes the ancient fluvial sediments.
Does work experience matter when training teachers to deal with school disengagement?
Authors: Rassameethes Bordin , Phusavat Kongkiti , Pastuszak Zbigniew 
Published: April 2024

BACKGROUND Traditionally, teachers with less work experience receive more training in non-academic areas such as school disengagement. This circumstance affects a school’s readiness when attempting to create a student-focused environment. Teachers need to have a consistent approach when dealing with disengaged students. OBJECTIVE The study examines the relationship between work experience on the decision relating to in-service training needs to cope with school disengagement. This study focuses on the schools from Bangkok Metropolitan Administration. METHODS The method consists of several steps. The first step is to identify a general set of non-academic training needs. The next step is to distribute the survey to teachers. Finally, statistical analysis is applied to examine the impacts from work experience. RESULTS Based on the surveys completed by 147 teachers who are categorized into four work-experience groups. The findings show that work experience does not affect the decisions regarding training needs. Thus, younger as well as older teachers alike should be provided with similar training programs to deal disengaged students. CONCLUSIONS Work experience should not be used as a criterion when selecting teachers when providing in-service training for non-academic areas. Consistent practice by teachers is needed when creating a student-focused environment.
Predictors of Loss of Ambulation in Duchenne Muscular Dystrophy: A Systematic Review and Meta-Analysis
Authors: Landfeldt E. , Alemán A. , Abner S. , Zhang R. , Werner C. , Tomazos I. , Ferizovic N. , Lochmüller H. , Kirschner J. 
Published: April 2024

Objective: The objective of this study was to describe predictors of loss of ambulation in Duchenne muscular dystrophy (DMD). Methods: This systematic review and meta-analysis included searches of MEDLINE ALL, Embase, and the Cochrane Database of Systematic Reviews from January 1, 2000, to December 31, 2022, for predictors of loss of ambulation in DMD. Search terms included “Duchenne muscular dystrophy” as a Medical Subject Heading or free text term, in combination with variations of the term “predictor”. Risk of bias was assessed using the Newcastle–Ottawa Scale. We performed meta-analysis pooling of hazard ratios of the effects of glucocorticoids (vs. no glucocorticoid therapy) by fitting a common-effect inverse-variance model. Results: The bibliographic searches resulted in the inclusion of 45 studies of children and adults with DMD from 17 countries across Europe, Asia, and North America. Glucocorticoid therapy was associated with delayed loss of ambulation (overall meta-analysis HR deflazacort/prednisone/prednisolone: 0.44 [95% CI: 0.40–0.48]) ( n = 25 studies). Earlier onset of first signs or symptoms, earlier loss of developmental milestones, lower baseline 6MWT (i.e.,<350 vs. ≥350 metres and <330 vs. ≥330 metres), and lower baseline NSAA were associated with earlier loss of ambulation ( n = 5 studies). Deletion of exons 3–7, proximal mutations (upstream intron 44), single exon 45 deletions, and mutations amenable of skipping exon 8, exon 44, and exon 53, were associated with prolonged ambulation; distal mutations (intron 44 and downstream), deletion of exons 49–50, and mutations amenable of skipping exon 45, and exon 51 were associated with earlier loss of ambulation ( n = 13 studies). Specific single-nucleotide polymorphisms in CD40 gene rs1883832, LTBP4 gene rs10880, SPP1 gene rs2835709 and rs11730582, and TCTEX1D1 gene rs1060575 ( n = 7 studies), as well as race/ethnicity and level of family/patient deprivation ( n = 3 studies), were associated with loss of ambulation. Treatment with ataluren ( n = 2 studies) and eteplirsen ( n = 3 studies) were associated with prolonged ambulation. Magnetic resonance biomarkers (MRI and MRS) were identified as significant predictors of loss of ambulation ( n = 6 studies). In total, 33% of studies exhibited some risk of bias. Conclusion: Our synthesis of predictors of loss of ambulation in DMD contributes to the understanding the natural history of disease and informs the design of new trials of novel therapies targeting this heavily burdened patient population.
PERLINDUNGAN KONSUMEN PERSEPKTIF HUKUM EKONOMI SYARIAH
Authors: . Hotman , Handayani Wiwik 
Published: April 2024

Prinsip ekonomi syariah merupakan prinsip yang berbasis Islam yang mengendalikan setiap pelaku usaha dan konsumen sebagai batasan-batasan untuk bertransaksi. Salah satu hal yang membedakan antara ekonomi syariah dengan ekonomi konvensional, adalah dasar yang dijadikan pedoman untuk berprilaku sesuai aturan yang sudah ada dan yang sudah ditetapkan berkenaan dengan hal ini ekonomi syariah lebih kental dengan hukum Islam yaitu al-qur’an dan hadist sesuai dengan syariat Islam.
Sistem ekonomi indonesia adalah sistem yang harus diterapkan sesuai dengan peraturan pemerintah dan sesuai dengan peraturan hukum islam agar adanya keselarasan diantara kedua hukum tersebut untuk memperlancar segala rutinitas umat manusai yang beretika baik jujur dan tidak merugikan orang lain.Setiap tindakan pasti berujung pertengkaran apabila tidak sesuai dengan aturan-aturan yang ada,perlu adanya regulasi hukum yang menjamin pihak konsumen maupun membuat jera para pelaku usaha untuk tidak semena-mena terhadap pelanggan dan memanipulasi sesuatu yang diperdagangkan untuk mendapatkan keuntungan maupun hasil yang sebesar-besarnya.perlu adanya pakar-pakar ekonomi terjun langsung untuk mengendalikan ekonomi indoensia agar perkembanganya semakin pesat tidak semakin turun rentan kemudian hilang ditelan bumi.
Perlu adanya perkiraan yang mengarah kepada perkembangan ekonomi indonesia sehingga bisa merubah keadaan.karena potensi indonesia terhadap ekonomi sangat besar dan tinggi.penunjangan pun perlu digencarkan untuk mendukung pergerakan ekonomi menuju ekonomi yang berkembang dan dengan adanya aturan yang dibuat memberikan batasan-atasan dan tidak ada alasan lagi memperkaya diri sendiri dengan cara yang merugikan karena aturan yang dibaut dibubuhi dengan sanksi-sanksi yang tegas.
PENETAPAN PEMBIAYAAN LEASING SYARIAH DI FIF KOTA METRO PERSPEKTIF HUKUM EKONOMI SYARIAH
Authors: . Sudirman 
Published: April 2024

Indonesia's financial development is also marked by the diversification of financial products, namely by the emergence of non-bank financing institutions that can be used as alternatives to meet the community's needs for the desired financing. The development of non-bank financial institutions that offer various forms of financing facilities will further expand the provision of alternative financing for the business world and the needs of the Indonesian people in the Indonesian economic system. This study aims to determine the determination of Islamic financing and the mechanism of sanctions for late payments at the Metro City FIF. This type of research is field research (field research). While the nature of this research is descriptive. The data sources used are primary and secondary data sources. Data was collected using interview and documentation techniques. The data from the findings are described descriptively and analyzed using inductive thinking.
The results of this study indicate that the determination of Islamic financing in the Islamic system is not known as the interest system as an instrument to obtain profits for the company. Because basically sharia financing in conducting business transactions uses a sale and purchase contract or known as murabahah, which is a contract used to procure an item by confirming the purchase price to the buyer and the buyer pays it in installments at a higher price as profit. The Sharia FIF mechanism if the consumer is unable to pay the installments then the goods will be withdrawn and resold. So that the FIF Syariah does not pay attention and even tends to eliminate the risk aspects that will be encountered when the customer/consumer occurs in the event of a delay in payment
ARTIFICIAL INTELEGENCE TRENDS IN EDUCATION AMONG SCHOOL ADMINISTRATORS IN MALAYSIA
Authors: Ramalingam Shanti , Maniam Mahendran 
Published: April 2024

In recent years, artificial intelligence (AI) has gained significant attention in the education sector in Malaysia. With the rapid advancement of technology, school administrators are recognizing the potential of AI to improve student learning outcomes and streamline administrative processes. In this narrative overview, we will discuss some of the AI trends in education that are currently being implemented or considered by school administrators in Malaysia. The awareness of the importance of digital learning are very much needed to be emphasize because without it, students will be left behind in terms of education. The main objective of this research is to identify the prospective impact of artificial technologies among school administrators in Malaysian schools with personalized learning, chatbots, predictive analytics, intelligent tutoring systems, and automated grading. This study also conducted to examine the level of competence of school administrators on the technology management and instructional technology using artificial technologies. The respondents of this study consisted of 40 secondary schools from Malaysia. Using the method of questionnaire survey and interview this study takes the entire education system of Malaysia as an example to explore the effect of AI on role cognition in the education system to streamline administrative processes. The findings of the study show that the level of competence among school administrators in technology management and instructional technology in leveraging AI to improve student outcomes and streamline administrative processes to the study process and to predict possible changes in educational landscape is at a moderate level. Therefore, school administrators need to give their full commitment to the use of instructional technology in order to increase productivity in teaching and learning as well as school management with the impact of artificial intelligence. This research will provide appropriate knowledge for all school administrators to adopt technology leadership features to enhance the school administration system and teacher teaching implementation at a higher level.
PENERAPAN SISTEM MANAJEMEN KESELAMATAN DAN KESEHATAN KERJA SEBAGAI PERAN PENCEGAHAN KECELAKAAN KERJA DI PT KONSUIL PERDANA INDONESIA AREA LUBUKLINGGAU
Authors: Effendi Muhamad , Surya Putri 
Published: April 2024

Masalah dalam penelitian ini adalah dalam penerapan SMK3 masih kurangnya kesadaran tenaga teknik tentang penggunaan alat pelindung diri dan tergolong Ketercapaian sama-sama cukup baik dan diperlukan peningkatan lagi. Penelitian ini menggunakan metode kualitatif penelitian menganalisis data dari hasil pengamatan langsung di PT Konsuil Perdana Indonesia Area Lubulinggau, hasil wawancara dengan kepala teknik dan para stafnya, dan evaluasi dari studi kepustakaan teori dan pendapat para ahli sebagai data pendukung. Penerapan SMK3 telah direncanakan dan diterapkan dengan cukup baik di PT Konsui Perdana Indonesia Area Lubuklinggau. Dan dari perbandingan hasil penelitian yang sesuai dengan peraturan Menteri Tenaga Kerja No 05/MEN/1996 lebih tinggi yaitu 60% dengan kiteria cukup baik. Sedangkan menurut indikator keselamatan dan kesehatan kerja yaitu 52% dengan kiteria cukup baik. Kesimpulan penelitian ini adalah dalam penerapan SMK3 yang menggunakan penerapan Peraturan Menteri Tenaga Kerja Nomor: PER.05/MEN/1996 dan indikator K3 Penerapan SMK3 memberi pengaruh yang cukup baik bagi PT Konsuil Perdana Indonesia Area Lubuklinggau, dilihat dari jumlah tenaga teknik yang mengalami kecelakaan dan penyakit kerja masih tergolong rendah dan tidak mempengaruhi pelaksanaan pekerjaan.
Procedural Deficiencies in Administrative Tribunals of Bangladesh: Exploring Alternative Tactics
Authors: Aktar Sharmin 
Published: April 2024

The present article demonstrates that a troublesome reality is now being faced by Administrative Tribunals, leaving a room highlighting problems that have been unaddressed since its inception. It is found that the jurisprudential concept of locus standi, so far as Administrative Tribunals are concerned, is not wide and comprehensive, even then it need not be extended due to its short domain of jurisdiction as to subject matter. Furthermore, there is no scope to condone the delay according to relevant provisions. In addition, the Act of 1980 does not mysteriously fix a period for the restoration of a case or setting aside an ex parte order. Whereas most of the litigations in Tribunals concern a lack of procedural fairness in departmental proceedings, therein the principle of ‘Natural Justice’ is not recognized. These lapses seriously endangered the future of this justice system but neither the legislature nor the judiciary has so far taken any serious step to check these realities. Therefore, scattered procedural complexities have been accommodated in this article based on the Act of 1980 as well as the Rules of 1982; and cases and interviewing have been used as the point of reference, but at the same time earnest effort has been spent for finding out solutions, guided by expediency and tradition.
Dhaka University Law Journal, 2023, 34 (2), 67-95
Scrutiny of chimeric antigen receptor activation by the extracellular domain: experience with single domain antibodies targeting multiple myeloma cells highlights the need for case-by-case optimization
Authors: Hanssens Heleen , Meeus Fien , De Vlaeminck Yannick , Lecocq Quentin , Puttemans Janik , Debie Pieterjan , De Groof Timo W. M. , Goyvaerts Cleo , De Veirman Kim , Breckpot Karine , Devoogdt Nick 
Published: April 2024

IntroductionMultiple myeloma (MM) remains incurable, despite the advent of chimeric antigen receptor (CAR)-T cell therapy. This unfulfilled potential can be attributed to two untackled issues: the lack of suitable CAR targets and formats. In relation to the former, the target should be highly expressed and reluctant to shedding; two characteristics that are attributed to the CS1-antigen. Furthermore, conventional CARs rely on scFvs for antigen recognition, yet this withholds disadvantages, mainly caused by the intrinsic instability of this format. VHHs have been proposed as valid scFv alternatives. We therefore intended to develop VHH-based CAR-T cells, targeting CS1, and to identify VHHs that induce optimal CAR-T cell activation together with the VHH parameters required to achieve this.MethodsCS1-specific VHHs were generated, identified and fully characterized, in vitro and in vivo. Next, they were incorporated into second-generation CARs that only differ in their antigen-binding moiety. Reporter T-cell lines were lentivirally transduced with the different VHH-CARs and CAR-T cell activation kinetics were evaluated side-by-side. Affinity, cell-binding capacity, epitope location, in vivo behavior, binding distance, and orientation of the CAR-T:MM cell interaction pair were investigated as predictive parameters for CAR-T cell activation.ResultsOur data show that the VHHs affinity for its target antigen is relatively predictive for its in vivo tumor-tracing capacity, as tumor uptake generally decreased with decreasing affinity in an in vivo model of MM. This does not hold true for their CAR-T cell activation potential, as some intermediate affinity-binding VHHs proved surprisingly potent, while some higher affinity VHHs failed to induce equal levels of T-cell activation. This could not be attributed to cell-binding capacity, in vivo VHH behavior, epitope location, cell-to-cell distance or binding orientation. Hence, none of the investigated parameters proved to have significant predictive value for the extent of CAR-T cell activation.ConclusionsWe gained insight into the predictive parameters of VHHs in the CAR-context using a VHH library against CS1, a highly relevant MM antigen. As none of the studied VHH parameters had predictive value, defining VHHs for optimal CAR-T cell activation remains bound to serendipity. These findings highlight the importance of screening multiple candidates.
Association between the systemic immuno-inflammation index and hearing loss: result from NHANES 2009–2018
Authors: Zhou Tingfeng , Mao Jiesheng , Zhu Pei , Yu Xinru , Yang Xiaokai 
Published: April 2024

BackgroundA novel inflammatory marker that measures the degree of systemic immunoinflammation, the systemic immuno-inflammation index (SII) is frequently used to forecast a number of illnesses. According to earlier studies, inflammation may play a role in the pathophysiology of hearing loss (HL).MethodsA sample from the National Health and Nutrition Examination Survey (NHANES) covering the years 2009 to 2018 was used in the current cross-sectional survey. Subgroup analysis and weighted multiple linear regression models were used to examine the independent linear correlation between SII and HL. Fitted smoothed curve analyses were also conducted to show the non-linear relationship between the two variables.ResultsAmong the 8,535 participants, the mean age was 40.92 ± 18.6 years, with 49.01% being male. Notably, individuals with hearing loss demonstrated an SII of 530.00 ± 320.72, while those with normal hearing displayed an SII of 491.21 ± 265.15. The mean ± SD values of low-frequency, speech-frequency, and high-frequency Pure Tone Average (PTA) hearing thresholds were 10.33 ± 9.79, 12.20 ± 11.11, and 22.48 ± 19.49 dB, respectively. A positive dose–response relationship between higher SII and hearing thresholds was observed after adjusting for potential confounders. Furthermore, the interaction analysis did not reveal any significant impact on this positive correlation.ConclusionThe results of our investigation suggest that the Systemic Inflammatory Index may serve as a potential biomarker for the likelihood of hearing loss. However, additional research is required to further elucidate the nature of this association.
A novel nomogram integrating body composition and inflammatory-nutritional markers for predicting postoperative complications in patients with adhesive small bowel obstruction
Authors: Wang Zhibo , Sun Baoying , Yu Yimiao , Liu Jingnong , Li Duo , Lu Yun , Liu Ruiqing 
Published: April 2024

BackgroundPostoperative complications in adhesive small bowel obstruction (ASBO) significantly escalate healthcare costs and prolong hospital stays. This study endeavors to construct a nomogram that synergizes computed tomography (CT) body composition data with inflammatory-nutritional markers to forecast postoperative complications in ASBO.MethodsThe study’s internal cohort consisted of 190 ASBO patients recruited from October 2017 to November 2021, subsequently partitioned into training (n = 133) and internal validation (n = 57) groups at a 7:3 ratio. An additional external cohort comprised 52 patients. Body composition assessments were conducted at the third lumbar vertebral level utilizing CT images. Baseline characteristics alongside systemic inflammatory responses were meticulously documented. Through univariable and multivariable regression analyses, risk factors pertinent to postoperative complications were identified, culminating in the creation of a predictive nomogram. The nomogram’s precision was appraised using the concordance index (C-index) and the area under the receiver operating characteristic (ROC) curve.ResultsPostoperative complications were observed in 65 (48.87%), 26 (45.61%), and 22 (42.31%) patients across the three cohorts, respectively. Multivariate analysis revealed that nutrition risk score (NRS), intestinal strangulation, skeletal muscle index (SMI), subcutaneous fat index (SFI), neutrophil-lymphocyte ratio (NLR), and lymphocyte-monocyte ratio (LMR) were independently predictive of postoperative complications. These preoperative indicators were integral to the nomogram’s formulation. The model, amalgamating body composition and inflammatory-nutritional indices, demonstrated superior performance: the internal training set exhibited a 0.878 AUC (95% CI, 0.802–0.954), 0.755 accuracy, and 0.625 sensitivity; the internal validation set displayed a 0.831 AUC (95% CI, 0.675–0.986), 0.818 accuracy, and 0.812 sensitivity. In the external cohort, the model yielded an AUC of 0.886 (95% CI, 0.799–0.974), 0.808 accuracy, and 0.909 sensitivity. Calibration curves affirmed a strong concordance between predicted outcomes and actual events. Decision curve analysis substantiated that the model could confer benefits on patients with ASBO.ConclusionA rigorously developed and validated nomogram that incorporates body composition and inflammatory-nutritional indices proves to be a valuable tool for anticipating postoperative complications in ASBO patients, thus facilitating enhanced clinical decision-making.