bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serial Lactate in Clinical Medicine – A Narrative Review
Authors: Falter Florian , Tisherman Samuel A , Perrino Albert C , Kumar Avinash B , Bush Stephen , Nordström Lennart , Pathan Nazima , Liu Richard , Mebazaa Alexandre 
Published: February 2025

Background Blood lactate is commonly used in clinical medicine as a diagnostic, therapeutic and prognostic guide. Lactate's growing importance in many disciplines of clinical medicine and academic enquiry is underscored by the tenfold increase in publications over the past 10 years. Lactate monitoring is presently shifting from single to serial measurements, offering a means of assessing response to therapy and to guide treatment decisions. With the promise of wearable lactate sensors and their potential integration in electronic patient records and early warning scores, the utility of serial lactate measurement deserves closer scrutiny. Methods Articles included in this review were identified by searching MEDLINE, PubMed and EMBASE using the term “lactate” alone and in combination with “serial”, “point of care”, “clearance”, “prognosis” and “clinical”. Authors were assigned vetting of publications according to their specialty (anesthesiology, intensive care, trauma, emergency medicine, obstetrics, pediatrics and general hospital medicine). The manuscript was assembled in multidisciplinary groups guided by underlying pathology rather than hospital area. Findings Lactate's clinical utility as a dynamic parameter is increasingly recognized. Several publications in the last year highlight the value of serial measurements in guiding therapy. Outside acute clinical areas like the emergency room, operating room or intensive care, obtaining lactate levels is often fraught with difficulty and delays. Interpretation Measuring serial lactate and lactate clearance offers regular feedback on response to therapy and patient status. Particularly on the ward, wearable devices integrated in early warning scores via the hospital IT system are likely to identify deteriorating patients earlier than having to rely on observations by an often-overstretched nursing workforce.
Evaluation of Maxillary Sinus Pathologies in Children and Adolescents with Cleft Lip and Palate Using Cone Beam Computed Tomography: A Retrospective Study
Authors: Çelik Ayşe , Ersan Nilüfer , Selvi-Kuvvetli Senem 
Published: February 2025

Objective The purpose of this study was to evaluate maxillary sinus (MS) pathologies in children and adolescents with cleft lip and palate (CLP) in comparison to a sex- and age-matched control group using cone beam computed tomography (CBCT), retrospectively. Method CBCT images obtained between the years 2014 and 2022 from a total of 130 patients aged between 7 and 18 were considered eligible for this study. Age, sex, and the type of MS pathologies in each sinus were recorded in CLP (n = 65) and control (n = 65) groups. The MS pathologies were categorized and recorded for both right and left sinuses separately as: (1) healthy; (2) mucosal thickening >3 mm; (3) polypoidal mucosal thickening; (4) partial opacification; and (5) complete opacification. In the CLP group, the cleft type and side were also recorded. Variations of polypoidal mucosal thickenings were subcategorized as small, large, and multiple. Results The mean age of the 130 patients (58 female, 72 male) was calculated as 12.43 ± 3.13. Among the patients in the study and control groups, polypoidal mucosal thickening was found to be the most frequent sinus pathology (25.4%), while total opacification was found to be the least frequent (1.6%). Overall, only the number of sinuses with mucosal thickening greater than 3 mm was statistically significantly higher in the CLP than that of the control group ( P < .05). In terms of cleft type and side, the frequency of the pathology based on the sinuses showed no significant difference in any of the pathology groups ( P > .05). Conclusion Incidental findings in the oral and maxillofacial region that are detected on CBCT images of CLP patients may play an important role in the early diagnosis of MS diseases and aid in the referral for further evaluation.
Intestinal Type Sinonasal Adenocarcinoma: A Clinicopathological Study of 48 Patients With Review of Literature
Authors: Ud Din Nasir , Akram Saba , Raza Muhammad , Ahmad Zubair 
Published: February 2025

Background Intestinal type sinonasal adenocarcinoma is a gland forming malignant tumor of sinonasal tract which is histologically and immunohistochemically similar to intestinal type adenocarcinomas. Intestinal type sinonasal adenocarcinoma has a well-recognized etiological association with occupational exposure to wood dusts. Objective To report the clinicopathological factors of intestinal type sinonasal adenocarcinoma and review the published literature. Methods Forty-eight tumors reported as intestinal type sinonasal adenocarcinoma were retrieved and clinicopathological features were noted. Results Age ranged from 22 to 79 (mean 44) years with 36 men and 12 women. Most patients were presented with nasal blockage and difficulty in breathing. Occupational exposure to dust was present in the majority of patients. Tumors were composed of papillae or acini lined by dysplastic intestinal type columnar epithelium with interspersed goblet cells. There were 13 well differentiated (low grade) and 35 poorly differentiated (high-grade) tumors. CDX2 and SATB2 were expressed by the tumor cells in most tumors. Follow-up was available in 24 patients (range 3 months to 10 years). Most of the patients received chemo and/or radiotherapy. Metastases occurred in 19 out of 24 patients. Brain metastases were very common. All patients with metastases died of their disease. Conclusion Clinical and morphological features in our series were similar to published studies. It is important for pathologists to remember the association of these tumors with occupational exposure to wood dusts and to exclude metastases of intestinal adenocarcinomas when confronted by these tumors in the sinonasal tract.
Prognostic Value of Perioperative Near-Infrared Spectroscopy Monitoring for Postoperative Acute Kidney Injury in Pediatric Cardiac Surgery: A Systematic Review
Authors: Niezen Cornelia K. , Modestini Marco , Massari Dario , Bos Arend F. , Scheeren Thomas W. L. , Struys Michel M. R. F. , Vos Jaap Jan 
Published: February 2025

Introduction Postoperative acute kidney injury (AKI) is a common postoperative complication in cardiac surgery, with varying reported incidences and prognostic factors. Renal hypoperfusion is believed to be a key factor contributing to postoperative AKI. Near-infrared spectroscopy (NIRS) monitoring, which assesses regional tissue saturation (RSO2), has been suggested as a tool to predict postoperative AKI. The aim of this systematic review was to examine the prognostic value of perioperative NIRS monitoring in predicting postoperative AKI in pediatric patients. Methods and Results After a systematic search in PubMed, EMBASE, and Cochrane library, twenty studies (1517 patients) were included. The inter-rater agreement on study quality was strong, yet a high risk of bias was identified. Conclusion The heterogeneity of the results—in part attributable to several potential confounding factors regarding study population, monitoring technique and the definition of AKI—together with the lack of a clear and consistent association between RSO2 values and AKI, currently preclude recommending NIRS monitoring as a reliable and valid clinical tool to “predict” AKI in the individual patient.
Hearing loss and the risk of dementia: A longitudinal analysis of the Korean National Health Insurance Service Senior Cohort
Authors: Jang Jae-Won , Lee Seung-Hwan , Kim Taesu , Lee Eunju , Park Sang Won , Yeo Na Young , Kim Young-Ju 
Published: February 2025

Background Hearing loss is a potentially modifiable risk factor implicated in dementia, with recent research suggesting an association between age-related hearing degradation and dementia. Objective This study aims to elucidate the relationship between hearing decline and dementia risk. Methods We analyzed data from 511,953 subjects from the Korean National Health Insurance Service-Senior Cohort (2002–2008). After excluding those diagnosed with dementia in 2002, 511,935 subjects were included. Subjects with hearing loss between 2002 and 2008 were selected and matched with a control group without hearing impairment based on age and gender. Statistical analyses, including Pearson's chi-squared test and the Cox proportional hazards model, were conducted, controlling for confounding variables such as household income and residential area. Subgroup analysis was also performed for Alzheimer's disease and vascular dementia. Results Subjects with hearing loss had a 1.245 times higher risk of all-cause dementia compared to those without hearing loss (adjusted hazard ratio over 3 years, 95% CI = 1.201–1.290), adjusting for gender, age, residence, and income. The adjusted hazard ratios for Alzheimer's disease over 3, 5, 7, and 10 years from the index date were 1.259 (95% CI = 1.211–1.308), 1.258 (95% CI = 1.208–1.310), 1.269 (95% CI = 1.215–1.325), and 1.235 (95% CI = 1.170–1.304), respectively. No significant association was found for vascular dementia, except for 3 years. Conclusions Hearing loss consistently increased the risk of all-cause dementia and Alzheimer's disease across timespans, suggesting a complex link between hearing loss and neurodegenerative diseases. These findings highlight the importance of early intervention and cognitive monitoring for individuals with hearing loss.
EXPRESS: Assessment of Working Memory abilities in Normal Hearing Individuals with and without Misophonia
Authors: Adline Princita Dsouza , Nisha Kavassery Venkateswaran , Prabhu Prashanth , Uppunda Ajith Kumar 
Published: February 2025

Purpose: The study aimed to evaluate working memory (WM) abilities in normal hearing individuals with and without misophonia using simple and complex working memory tasks and to correlate WM abilities with severity of misophonia. Method: The data was collected employing a standard group comparison and a non-probability purposive sampling method. The current study comprised of 40 participants aged 18-30 years, who were classified into two groups (with and without misophonia) based on the scores obtained in Misophonia Assessment Questionnaire (MAQ). Simple tasks including forward digit span and backward digit span and complex tasks including operation span and reading span were used to assess WM abilities. Results: WM abilities, measured using simple WM tasks, were comparable between the two groups. Among the complex tasks, although the operation span scores revealed no statistically significant difference, there was a statistically significant difference in the reading span scores. Conclusions: The performance of individuals with misophonia remained similar to those without misophonia in simple WM tasks. However, their WM performance becomes poorer as tasks become more demanding.
Synthesis of the clinical utilities and issues of intraoperative imaging devices in clinical reports: a systematic review and thematic synthesis
Authors: Suzuki Hiroyuki , Tsuboko Yusuke , Tamura Manabu , Masamune Ken , Iwasaki Kiotaka 
Published: February 2025

Abstract

Background
Intraoperative imaging devices (i-ID), such as intraoperative optical coherence tomography (iOCT), offer surgeons critical insights previously unobservable, enhancing surgical precision and safety. Despite their benefits, i-IDs present challenges that necessitate early identification and synthesis of clinical issues to promote safer surgical implementation. This study aims to explore the potential of Qualitative Evidence Synthesis (QES) for synthesising qualitative evidence from clinical reports regarding the clinical utility and issues associated with iOCT devices.

Methods
In June 2022, we conducted a systematic literature search using PubMed, Web of Science, Embase, and the Cochrane Library for articles on iOCT for retinal surgery. Criteria included articles in English, with at least ten cases, and providing qualitative insights into iOCT’s utilities and issues. We performed thematic synthesis from the identified articles using qualitative data analysis software, beginning with initial coding of the ‘Results’ and ‘Discussion’ sections to create themes reflecting iOCT’s utilities and issues. The created themes were further refined through axial coding and were used to construct a model illustrating iOCT’s potential influence on patient outcomes. The reliability and validity of the themes were ensured through independent coding, expert consultations, and iterative revisions to achieve consensus among reviewers.

Results
The QES approach enabled systematic data extraction and synthesis, providing a comprehensive view of both the utilities and issues associated with iOCT. Our findings emphasise the significant role of iOCT in enhancing decision-making, specifically in membrane peeling tasks and in detecting preoperatively undetected conditions such as full-thickness macular holes. This study also revealed critical insights into the technical challenges associated with iOCT, including device malfunctions and procedural interruptions, which are vital for improving device safety and integration into surgical practice.

Conclusion
The application of QES facilitated a thorough investigation into the clinical utilities and issues of iOCT, encouraging the application of this method in the ongoing evaluation of i-ID technologies. This initial experience with QES confirms its potential in synthesising qualitative clinical data and suggests its applicability to other i-ID modalities. This approach enhances the reliability of findings and provides a solid foundation for assessing clinical utilities and issues for policymakers and medical specialists.
Neutralization-based seroprevalence of Toscana virus and sandfly fever Sicilian virus in dogs in the Republic of Kosovo
Authors: Xhekaj Betim , Kurum Elif , Stefanovska Jovana , Cvetkovikj Aleksandar , Sherifi Kurtesh , Rexhepi Agim , Charrel Remi , Kniha Edwin , Ayhan Nazli 
Published: February 2025

Abstract

Background
Phlebotomine sand flies are the key vectors for phleboviruses (order Hareavirales and family Phenuiviridae), of which some are associated with febrile diseases and nervous system infections. In the Mediterranean Basin, Toscana virus (TOSV; Phlebovirus toscanaense) and sandfly fever Sicilian viruses (SFSV; Phlebovirus siciliaense) are important human pathogens, and their endemicity has been known for decades, particularly in the Balkan countries. While the circulation of both viruses is highly evident among humans and livestock in the Central Balkan country Kosovo, data from companion animals are scarce; however, it might help to further assess the distribution of both viruses in the country.

Methods
Sera of dogs from all seven districts of Kosovo were screened for TOSV and SFSV antibodies by seroneutralization assays.

Results
Altogether, 45 of 288 (15.6%) samples showed anti-Phlebovirus antibodies, of which 36 (12.5%) were against TOSV, 11 (3.8%) were against SFSV, and 2 (0.7%) were positive for antibodies against both viruses.

Conclusions

Phlebovirus seroprevalence was observed in all seven districts of the country, generally being higher for TOSV compared with SFSV. Our study presents the first assessment of neutralization-based seroprevalence of two medically important phleboviruses among dogs in the Republic of Kosovo. Although healthy dogs are unsusceptible to Phlebovirus infection, dogs with leishmaniasis can be potential amplifying hosts. Given the high number of stray dogs, frequent uncontrolled spreading of phleboviruses in dogs, and potential spillover in populated regions of the country, these findings should be taken into consideration.

Graphical Abstract
Genetic and molecular characterization of a novel reassortant H3N2 influenza virus from a sick pig in Eastern China in 2019
Authors: Yang Fan , Cheng Linfang , Liu Fumin , Yao Hangping , Wu Nanping , Xu Lihua , Wu Haibo 
Published: February 2025

Abstract
Swine influenza viruses (SIVs) cause clinical respiratory symptoms associated with high mortality rates among pigs. Because pigs can be a “mixing vessel” for influenza viruses, the SIV might pose a serious threat to animal and human health. In this study, an H3N2 SIV [A/swine/Zhejiang/19/2019(H3N2) (ZJ-SW19)] was isolated from a sick pig in Eastern China in 2019, and its molecular genetics were characterized. Phylogenetic analysis demonstrated the hemagglutinin (HA) and neuraminidase (NA) segments of ZJ-SW19 are highly homologous with those of H3N2 SIVs, belonging to human-like lineages; in contrast, the remaining six SIV segments (PB2, PB1, PA, NP, M, and NS) demonstrate the highest similarity with H1N1 SIVs isolated in East Asia during 2014–2020. The in vitro analysis of the virus’s growth kinetics revealed that ZJ-SW19 can replicate efficiently in various mammalian and avian cell lines (including MDCK, A549, and DF-1). The receptor-binding analysis results indicated that ZJ-SW19 can bind to human-like receptors (α-2,6-linked sialic acid) and avian-like receptors (α-2,3-linked sialic acid). Moreover, ZJ-SW19 demonstrated significant differences compared with avian- and human-origin H3N2 influenza viruses in the antigenic analysis. Finally, in the pathogenicity test, ZJ-SW19 effectively replicated in the mouse lungs with moderate virulence. Therefore, continuous circulation of novel reassortant H3N2 SIVs indicates the need for long-term, close surveillance of influenza viruses in pig herds.
Influence of Air Content on the Behavior of RC Beams Subjected to Freezing and Thawing
Authors: Kim Sangwoo , Lee Yujeong , Kim Jinsup , Han Dongyeop 
Published: February 2025

Abstract
Research on concrete durability during prolonged use has been ongoing due to concrete’s widespread use in construction. Freeze–thaw cycles exert a significant impact on concrete durability, especially in regions with harsh climates. While existing studies primarily focus on material aspects, research on the performance degradation of reinforced concrete (RC) structures is limited. This limitation is attributed to the inadequacy of current freeze–thaw testing standards for large structures like RC structures. Therefore, there is a need to propose freeze–thaw testing methods tailored for RC members. This study investigates the influence of air content and freeze–thaw cycles on the material and structural properties of RC beams, proposing a novel rapid freeze–thaw testing method for RC members. The study compares this new method (N test) with the conventional ASTM C666/C666M-15 rapid freeze–thaw testing procedure (A test), aiming to establish a correlation between the two experiments. Concrete mixtures with air content ranging from 0 to 9% underwent two types of freeze–thaw tests, followed by flexural testing of RC beams. The results were analyzed for air content, slump, compressive strength, mass loss, crack patterns, and failure modes, and they offer insights into the relationship between air entrainment, freeze–thaw resistance, and the structural behavior of RC under diverse environmental conditions.
CDCA genes as prognostic and therapeutic targets in Colon adenocarcinoma
Authors: Zhao Zongquan , Feng Xinwei , Chen Bo , Wu Yihong , Wang Xiaohong , Tang Zhenyuan , Huang Min , Guo Xiaohua 
Published: February 2025

Abstract

Objectives
The study investigates the role of Cell Division Cycle Associated (CDCA) genes in colorectal cancer (COAD) by analyzing their differential expression, epigenetic alterations, prognostic significance, and functional associations.

Methodology
This study employed a detailed in silico and in vitro experiments-based methodology.

Results
RT-qPCR assays reveal significantly elevated mRNA levels of CDCA2, CDCA3, CDCA4, CDCA5, CDCA7, and CDCA8 genes in COAD cell lines compared to controls. Bisulfite sequencing indicates reduced promoter methylation of CDCA gene promoters in COAD cell lines, suggesting an epigenetic regulatory mechanism. Analysis of large TCGA datasets confirms increased CDCA gene expression in COAD tissues. Survival analysis using cSurvival database demonstrates negative correlations between CDCA gene expression and patient overall survival. Additionally, Lasso regression-based models of CDCA genes predict survival outcomes in COAD patients. Investigating immune modulation, CDCA gene expression inversely correlates with immune cell infiltration and immune modulators. miRNA-mRNA network analysis identifies regulatory miRNAs targeting CDCA genes, validated by RT-qPCR showing up-regulation of has-mir-10a-5p and has-mir-20a-5p in COAD cell lines and tissues. Drug sensitivity analysis suggests resistance to specific drugs in COAD patients with elevated CDCA gene expression. Furthermore, CDCA gene expression correlates with crucial functional states in COAD, including
“angiogenesis, apoptosis, differentiation, hypoxia, inflammation, and metastasis.” Additional in vitro experiments revealed that CDCA2 and CDCA3 knockdown in SW480 and SW629 cells significantly reduced cell proliferation and colony formation while enhancing cell migration.

Conclusion
Overall, the study elucidates the multifaceted role of CDCA genes in COAD progression, providing insights into potential diagnostic, prognostic, and therapeutic implications.
Use of pulse oximeter plethysmograph waveform to monitor patients with acute exacerbation of obstructive airway diseases
Authors: Khalil Magdy Mohamed , Sweillm Hend Mohamed Elsayed , Elsamad Ahmed Mohamed Abd 
Published: February 2025

Abstract

Background
Acute exacerbation of obstructive airway diseases is the most frequent acute clinical scenario in ER in chest hospitals. There are limited objective and continuous real-time measures of acute exacerbation severity to guide treatment. Pulse oximeter plethysmograph wave is an objective bedside measure of change in blood volume beneath the probe and was found to correlate well with pulsus paradoxus which is one of the signs of respiratory distress.

Objective
To assess using pulse oximeter plethysmograph to monitor severity and response to therapy in patients with acute exacerbation of obstructive airway diseases.

Patients and methods
This study was a prospective cross-sectional study conducted on 100 patients, 45 patients with bronchial asthma exacerbation and 55 patients with COPD exacerbation, who attended the 23 July Chest Hospital ER from January 2023 to September 2023. Baseline variation (BLV) of pulse oximeter waveform of these patients was assessed qualitatively (visually) and quantitatively (maximum distance from baseline in mm) during the course of management in ER, and results correlated with severity indices and outcome.

Results
On ER admission, BLV was 3–13 mm with a median IQR 5 (4–7 mm) in 100 patients. There was a significant correlation between quantitative BLV and other signs of exacerbation severity (heart rate, respiratory rate, pulsus paradoxus and AAIRS for asthma, and Borg score for COPD). Forty patients improved under treatment and were discharged home, while 60 patients showed no improvement and required admission to hospital. Changes in BLV correlated well with the response to therapy and outcome in all patients. BLVs were recognizable by visual assessment as well.

Conclusion
BLV of plethysmograph wave is a reliable simple, non-invasive, and real-time tool in assessing severity and response to treatment of acute exacerbation of obstructive air way diseases. It is thus useful in monitoring and triaging these patients in ER and critical care settings.