bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of total glucosides of paeony on serum inflammatory cytokines in animal models of rheumatoid arthritis: a systematic review and meta-analysis
Authors: He Mengdi , Hu Zhipeng , Yang Maoyi 
Published: March 2024

Background: Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic synovitis of the affected joints. Total glucosides of paeony (TGP) capsules have been widely used clinically for the treatment of RA with good efficacy and safety. However, its effect on inflammatory cytokines remains unclear.Objectives: This study aimed to summarize the effect of TGP on the expression level of serum inflammatory cytokines in RA animal models and its potential mechanisms.Methods: Six databases were searched up to 14 August 2023, relevant animal experiment studies were screened, data were extracted, and the SYRCLE animal experiment bias risk assessment tool was used for risk assessment.Results: A total of 24 studies were included, including 581 animals. Results showed that compared with the model control group, TGP decreased the levels of TNF-α, IL-1β, IL-6, and PGE2 and increased the levels of TGF-β1 after 1–2 weeks of intervention, decreased the levels of TNF-α, IL-1β, IL-6, IL-2, IL-17, IL-17α, IL-21, VEGF, IFN-γ and PGE2 and increased the levels of IL-10 and IL-4 after 3–4 weeks of intervention, decreased the levels of TNF-α, IL-6, IL-17α and increased the level of IL-10 after 8 weeks of intervention. There was no significant difference in the effects of TGP on the levels of IL-10, IL-17, and IFN-γ after 1–2 weeks of intervention and IL-1 and TGF-β1 after 3–4 weeks of intervention.Conclusion: In summary, based on the existing studies, this study found that compared with the control group of the RA animal model, TGP can reduce the levels of serum pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6 and increase the levels of serum anti-inflammatory cytokines such as IL-10, exerting an anti-inflammatory effect by regulating and improving the levels of inflammatory cytokines, and thus alleviating the disease. Given the low quality of the included studies and the lack of sufficient evidence, more high-quality studies are still needed to validate the results of this study.
Endophytic non-pathogenic Fusarium oxysporum reorganizes the cell wall in flax seedlings
Authors: Wojtasik Wioleta , Dymińska Lucyna , Hanuza Jerzy , Burgberger Marta , Boba Aleksandra , Szopa Jan , Kulma Anna , Mierziak Justyna 
Published: March 2024

IntroductionFlax (Linum usitatissimum) is a crop producing valuable products like seeds and fiber. However, its cultivation faces challenges from environmental stress factors and significant yield losses due to fungal infections. The major threat is Fusarium oxysporum f.sp lini, causing fusarium wilt of flax. Interestingly, within the Fusarium family, there are non-pathogenic strains known as biocontrols, which protect plants from infections caused by pathogenic strains. When exposed to a non-pathogenic strain, flax exhibits defense responses similar to those seen during pathogenic infections. This sensitization process activates immune reactions, preparing the plant to better combat potential pathogenic strains. The plant cell wall is crucial for defending against pathogens. It serves as the primary barrier, blocking pathogen entry into plant cellsMethodsThe aim of the study was to investigate the effects of treating flax with a non-pathogenic Fusarium oxysporum strain, focusing on cell wall remodeling. The infection’s progress was monitored by determining the fungal DNA content and microscopic observation. The plant defense response was confirmed by an increase in the level of Pathogenesis-Related (PR) genes transcripts. The reorganization of flax cell wall during non-pathogenic Fusarium oxysporum strain infection was examined using Infrared spectroscopy (IR), determination of cell wall polymer content, and analysis of mRNA level of genes involved in their metabolism.Results and discussionIR analysis revealed reduced cellulose content in flax seedlings after treatment with Fo47 and that the cellulose chains were shorter and more loosely bound. Hemicellulose content was also reduced but only after 12h and 36h. The total pectin content remained unchanged, while the relative share of simple sugars and uronic acids in the pectin fractions changed over time. In addition, a dynamic change in the level of methylesterification of carboxyl groups of pectin was observed in flax seedlings treated with Fo47 compared to untreated seedlings. The increase in lignin content was observed only 48 hours after the treatment with non-pathogenic Fusarium oxysporum. Analysis of mRNA levels of cell wall polymer metabolism genes showed significant changes over time in all analyzed genes. In conclusion, the research suggests that the rearrangement of the cell wall is likely one of the mechanisms behind flax sensitization by the non-pathogenic Fusarium oxysporum strain. Understanding these processes could help in developing strategies to enhance flax’s resistance to fusarium wilt and improve its overall yield and quality.
Validity and reliability of the Difficulties in Emotion Regulation Scale Short Form in Indonesian non-clinical population
Authors: Danasasmita Febrianti Santiardi , Pandia Veranita , Fitriana Efi , Afriandi Irvan , Purba Fredrick Dermawan , Ichsan Abdullah , Pradana Kent , Santoso Alfonso Haris Setia , Mardhiyah Fithriani Salma , Engellia Rita 
Published: March 2024

IntroductionEmotion dysregulation is a transdiagnostic marker for vulnerability and has high comorbidity rates across various range of disorders among adolescents and young adults, highlighting the crucial need for precise assessment tools to recognize its significant impact on well-being. The Difficulties in Emotion Regulation Scale Short Form (DERS-SF) is a comprehensive instrument designed to measure the ability to regulate emotion. This study aimed to investigate the psychometric properties of DERS-SF among the non-clinical population, particularly high school and university students in Indonesia.MethodsA total of 738 senior high school and university students completed the Indonesian version of DERS-SF and standard questionnaires to assess its validity, consisting of the Depression Anxiety Stress Scale (DASS), the Beck Depression Inventory-II (BDI-II) for young adults and the Children Depression Inventory (CDI) for adolescents. Three models were examined in factorial validity tests using confirmatory factor analysis.ResultsThe results showed that DERS-SF had an overall good internal consistency with Cronbach’s alpha coefficient of.89 for the 18-item version,.90 for the 17-item version, and.91 for the 15-item version. Test-retest reliability was moderate with a value of.67. In addition, it had good satisfactory content as shown by item content validity index (I-CVI) = .96 and scale content validity index (S-CVI) = .83, as well as convergent validity. All subscales scores showed a positive and strong correlation with DASS, BDI-II, and CDI except awareness. Based on confirmatory factor analysis (CFA), the correlated 6-factor model excluding item number 6, and the 5-factor model excluding awareness were suitable to use in non-clinical populations.ConclusionThis study established the removal of the awareness subscale in the DERS-SF Indonesian version, resulting in better reliability and validity than the original version with complete subscales.
Ô droit ! Suspends ton vol ! La protection des rives des lacs de montagne de la théorie juridique à la pratique alpine
Authors: Moulin Sabine 
Published: March 2024

La protection juridique des lacs, comme élément de paysage, est, en France, séculaire. Elle a été renforcée en montagne par la
loi du 9 janvier 1985 dite loi «Montagne » et par la loi du 3 janvier 1986 dite loi «Littoral » en fonction de la superficie des lacs. Toutefois, cette protection n’a cessé de s’éroder au fil des modifications législatives.
C’est pourquoi, après avoir rappelé la réglementation d’urbanisme applicable aux lacs et plans d’eau de montagne et son évolution, nous avons souhaité questionner son application d’un point de vue théorique et pratique en examinant notamment sa mise en oeuvre
à différentes échelles spatiales, allant de la planification stratégique des massifs aux autorisations d’occupation des sols. Force est de constater que malgré ses insuffisances d’une part, et sa mise en oeuvre minimaliste et partielle d’autre part, la loi
s’avère indispensable pour protéger les lacs de la multiplicité des projets d’aménagements qui concernent aujourd’hui aussi bien leurs rives que leur surface.
Lacs publics mais rives (en partie) privées : analyse d’un paradoxe géo-légal
Authors: Nikolli Alice 
Published: March 2024

Large perialpine lakes belong to the public domain, with slight legal differences in each alpine country. Historical reasons explain this public status, as their use for navigation. In theory, this status ensures free access to the lake, for tourism and recreation among other functions. Building from French, Italian and various Swiss cantons case studies, this paper intertwines the legal status of public lakes and geographical analyses about their uses and empirical access to their shoreline. I argue that the legal regime of public domain constructed the “ lake” object according to a very restrictive spatial delimitation, limited to the water body itself and occasionally expanded to the shores when rights of way are provided. This spatial extent still shrank between the late 19th and the early 20th centuries, owing to the shoreline urbanisation-privatisation process which suppressed some of these rights of way.
Nowadays, social demand for accessing the lakes is strong but hardly satisfied because of the coastal privatisation.
This context challenges the legal construction of the “ lake” as a spatially restrictive object. The public domain
regime is theoretically very protective but this spatially restricted delimitation prevents it from being really efficient
in terms of public access to the lakes. The paper thus proposes to explain this geo-legal paradox.
Teaching English for Asking and Giving Opinion Learning Material through Cublak-Cublak Suweng Game
Authors: Elzahra Hilda Rizqi 
Published: March 2024

During the learning process, students need something that is fun, easy to remember, and gives a good understanding of the material. In this case, teachers need to introduce fun learning innovations like games. Students have problems with learning English, especially in learning vocabulary. This study aims to find out how traditional cublak-cublak-suweng game procedures can be used as an effective way to help students learn English vocabulary. The research was conducted at MI Asy-Syafiiyyah 2 Brebes in 5th grade with a total of 24 students. The data were analyzed using quantitative and qualitative methods. The design of this study is classroom action research, covering four activities: planning, action, observation, and reflection. The result of the study showed that the cublak-cublak-suweng game can improve the student's vocabulary and recommend such materials to the student.
Pemberian SMS reminder efektif memperbaiki status gizi antropometri pasien hemodialisis
Authors: Widiany Fery Lusviana , Afriani Yuni 
Published: March 2024

Latar Belakang: Hemodialisis pada umumnya dilakukan rutin setiap dua kali seminggu dengan waktu kurang lebih 5 jam setiap menjalani hemodialisis. Pasien yang menjalani hemodialisis rutin akan mengalami malnutrisi asupan protein yang tidak adekuat, rendahnya kadar albumin dalam darah, gangguan gastrointestinal seperti rasa mual dan muntah, serta menurunnya nafsu makan sehingga berisiko menurunkan status gizi pasien. Salah satu pelayanan gizi rawat jalan pada kasus hemodialisis adalah edukasi gizi yang dapat diberikan melalui pengiriman SMS secara rutin tiap hari kepada pasien (SMS Reminder). Tujuan: Mengetahui efektivitas pemberian SMS reminder terhadap status gizi pasien hemodialisis. Metode: Jenis penelitian kuasi eksperimental dengan melibatkan 15 responden untuk masing-masing kelompok perlakuan dan kontrol. Kriteria inklusi adalah pasien hemodialisis berusia >18 tahun, hemodialisis rutin setiap dua kali per minggu, bersedia menjadi responden, dan mengikuti prosedur penelitian. Kriteria eksklusi adalah terdapat udema anasarka dan komplikasi keganasan penyakit. Variabel bebas adalah pemberian SMS reminder, variabel terikatnya status gizi antropometri. Data dianalisis secara univariat dan analisis bivariat menggunakan uji Chi-square. Hasil: Uji Chi-square menunjukkan bahwa pemberian SMS reminder efektif mempengaruhi status gizi antropometri pasien hemodialisis (p-value = 0,028); Nilai RR = 2,500 yang berarti bahwa responden yang memperoleh SMS reminder memiliki kemungkinan 2,5 kali lebih besar untuk berstatus gizi baik dibandingkan yang tidak memperoleh SMS reminder. Kesimpulan: Pemberian SMS reminder efektif memperbaiki status gizi antropometri pasien hemodialisis. Pasien yang memperoleh SMS Reminder memiliki kemungkinan 2,5 kali lebih besar untuk berstatus gizi baik dibandingkan yang tidak memperoleh SMS Reminder.
Faktor sosio ekonomi demografi terhadap kejadian infeksi kecacingan pada anak Sekolah Dasar
Authors: Mahmudah Umi , Dirgahayu Paramasari , Wasita Brian 
Published: March 2024

Latar belakang: Infeksi kecacingan merupakan masalah kesehatan masyarakat di negara-negara berkembang seperti Indonesia. Anak sekolah dasar merupakan golongan yang paling berisiko terhadap kejadian infeksi kecacingan. Infeksi ini dipengaruhi oleh beberapa faktor yaitu kondisi sanitasi lingkungan, perilaku personal hygiene, serta kondisi sosio ekonomi demograf daerah sekitar. Kondisi sosio demograf yang berbeda di setiap wilayah mengakibatkan terjadinya infeksi kecacingan yang berbeda–beda. Tujuan: Untuk mengetahui hubungan faktor sosio ekonomi demograf terhadap kejadian infeksi kecacingan pada anak sekolah dasar. Metode: Penelitian ini merupakan penelitian observasional dengan rancangan cross sectional, pada populasi anak sekolah dasar kelas 1 sampai kelas 5 dengan jumlah 92 siswa, sedangkan besar sampel penelitian berjumlah 74 siswa di SD Barengan Kecamatan Teras Kabupaten Boyolali dengan teknik pengambilan sampel secara purposive. Data kecacingan pada anak diperoleh dengan pengambilan sampel feses dan diperiksa menggunakan metode formol ether concentration di Laboratorium Parasitologi Fakultas Kedokteran Universitas Sebelas Maret. Data sosio ekonomi demograf diperoleh dengan kuisioner dengan metode wawancara. Analisis data diolah menggunakan chi square. Hasil: Prevalensi kejadian infeksi kecacingan pada anak sekolah dasar di SD Barengan Kecamatan Teras Kabupaten Boyolali adalah 40,21%. Pendidikan ayah (p=0,159) dan pendidikan ibu (p=0,352) tidak berhubungan dengan kejadian infeksi kecacingan. Penghasilan ayah (p=0,330) dan penghasilan ibu (p=1,152) tidak berhubungan dengan kejadian infeksi kecacingan. Kesimpulan: Pendidikan ayah, pendidikan ibu, penghasilan ayah dan penghasilan ibu tidak berhubungan dengan kejadian infeksi kecacingan.
Bendability enhancement of 3D interconnections with out-of-plane corrugation for flexible hybrid electronics
Authors: Liu Chang , Hoshi Tadaaki , Shen Jiayi , Shinoda Atsushi , Kino Hisashi , Tanaka Tetsu , Fukushima Takafumi 
Published: March 2024

Abstract
This study focuses on enhancing the bendability of flexible interconnects with out-of-plane corrugation for flexible hybrid electronics. We propose two typical configurations of 3D corrugated interconnects: serpentine and trapezoidal. Three methods are introduced to fabricate these corrugated interconnects. The advantages and drawbacks of each fabrication strategy are discussed, and the impact of the 3D corrugation geometry and material on bendability is elucidated. In addition, the material properties of two types of negative photosensitive materials, SU-8 and F-PD (flexible-photoimageable dielectric), are compared. Results show that the resistance increase of 3D corrugated interconnects after a 5 mm radius bending test is drastically lower (by approximately 1900%–2000%) than that of conventional 2D planar interconnects.
Measurement of distance and speed between transmitter and receiver using the propagation time of underwater acoustic communication signals with orthogonal signal division multiplexing
Authors: Ishijima Ryoichi , Ebihara Tadashi , Wakatsuki Naoto , Maeda Yuka , Mizutani Koichi 
Published: March 2024

Abstract
This paper proposes a procedure for measuring transmitter–receiver (Tx–Rx) distance using acoustic communication signals to realize communication and positioning underwater with the same signal and device. Specifically, we focus on an underwater acoustic communication using orthogonal signal division multiplexing, where a pilot signal and messages are placed in the time–frequency domain. In this paper, we show that measurements of both Tx–Rx distance and speed are available by utilizing the pilot signal. We conducted a sea trial and evaluated the performance of the proposed method. During the experiment, the Tx–Rx distance was 50–550 m. The obtained results suggest that the proposed method can measure the Tx–Rx distance and speed in a specific environment. The mean absolute error and the standard deviation error of ranging are 4.0 and 2.7 m, respectively, while those of measurement speed are 0.13 and 0.22 m s−1, respectively.
Disappearance of cobalt particles above nanocrystalline diamond films by HF-CVD on cemented tungsten carbide
Authors: Bando Takahiro , Miyahara Yuki , Saiki Yoshinori , Kito Jumpei , Watanabe Seiya , Takikawa Hirofumi , Hattori Takahiro , Sugita Hiroaki 
Published: March 2024

Abstract
In this study, the possibility of the disappearance of Co particles on the surface of nanocrystalline diamond (NCD) films with large thicknesses was examined. It is shown that the number of Co particles decreased clearly with larger thicknesses. In the thickest case, the Co particles disappeared almost completely. Investigation with energy-dispersive spectroscopy for the cross section of the NCD films suggested that the Co particle was embedded during the growth of the NCD film. Our observations will contribute to depositing smooth NCD films on tools without the embrittlement of substrates by Co etching.
Pelatihan Pembuatan Laporan Keuangan Pada UMKM Kampung Madu Kabupaten Kediri
Authors: Purwanti Lilik , Triyuwono Iwan , Zuhrotin Nasyi’ah Eny , Prakoso Aryo 
Published: March 2024

This community service activity by the Faculty of Economics and Business team of Universitas Brawijaya aims to share the knowledge and skills of MSME actors in conducting bookkeeping and preparing financial statement activities. This activity is very much needed because MSME activists still lack knowledge and skills in bookkeeping, preparing financial reports so that it is difficult to know the position of their business profit or loss. In addition, by having financial reports, MSMEs that experience obstacles in accessing financing or obtaining tax incentives can be resolved. The method of implementing this community service consists of socialization activities, training activities and evaluation for participating MSMEs. The activities were carried out for MSME players in Kampung Madu, Badas Village, Kediri Regency. The training covered topics such as financial literacy and financial application. Upon completion of the training, MSME participants gained a deeper understanding of the importance of financial literacy, financial reporting and the use of technology in financial reporting. This training makes increased awareness can provide significant benefits for MSME actors, especially by strengthening financial strategy efforts and improving the welfare of MSME stakeholders.
INTELLIGENCE ANALYTICAL SUBSYSTEM OF CORPORATE MANAGEMENT (ON THE EXAMPLE OF AN OIL & GAS COMPANY)
Authors: Krasnyuk Maxim , Hrashchenko Iryna , Kulynych Yurii , Sydorenko Tetiana , Krasniuk Svitlana 
Published: March 2024

The changes that have taken place in the Ukrainian economy in recent years due to the consistent impact of global macroeconomic, epidemiological and military factors of the current deep crisis - actualized for enterprises and corporations a complex adaptive reorganization of their analytical subsystem of their management [1, 2].
In addition, in order to be consistently effective in today's global business environment (liberalization of markets, their globalization, increased competition, decreasing consumer loyalty, constant variation in oil and gas prices, etc.), oil and gas companies must have an innovative data and knowledge environment that allows seamless and effective joint leveraging knowledge inside the corporation and across the value chain [3]. The application of knowledge-based decision support systems as an important tool of innovative management policy enables effective and sustainable management of a complex of integrated processes of an oil and gas production company (mitigating the impact of crisis factors) [4].
The scientific and practical results presented in the article regarding the methodology and design of innovative analytical subsystem of the corporation management information systems should be taken into account when reengineering corporate information systems not only in the oil and gas industry in Ukraine [5-6].
Moreover, the obtained results are relevant and applicable not only for local companies, but also for international corporations on emerging markets in the context of global and regional macroeconomic and edipemical crisis phenomena.
POSSIBILITIES OF USING ARTIFICIAL INTELLIGENCE IN THE EDUCATION SYSTEM OF GEORGIA
Authors: Makasarashvili Tamar , Giguashvili Giuli 
Published: March 2024

In the era of digital transformation, among the technological solutions that will completely change the life of humanity, artificial intelligence takes the first place. It can be used to expand economic borders between countries and businesses. There is no future without artificial intelligence. Accordingly, artificial intelligence use is one of the promising directions for achieving economic well-being in our country. Artificial intelligence is already among us and participates in professional and daily activities in one form or another. Artificial intelligence is actively introduced in all areas of our lives, including education. With the ability to analyze large amounts of data, make predictions, and provide personalized experiences, artificial intelligence has become a powerful tool in recent years to improve the quality and accessibility of education as well as promote inclusive learning. We can talk about the possible benefits of using artificial intelligence in education: it can improve the learning process, it is possible to completely change all the education systems known to us, create perfect teaching materials, and establish a high standard of research. From automated assessment to personalized tutoring, AI can individually address the academic needs of each student and teacher.
The article examines the features of artificial intelligence use in the education field and determines the possibilities for its improvement.
ЩОДО ВПЛИВУ МУФТИ СПРЯЖЕННЯ НА РЕЗУЛЬТАТИ ДИНАМІЧНИХ ВИМІРЮВАНЬ КУТОВОЇ ШВИДКОСТІ АСИНХРОННИХ МАШИН З ЕНКОДЕРОМ
Authors: Кухарчук Василь , Голодюк Володимир 
Published: March 2024

Шляхом математичного моделювання встановлено, що механічне з’єднання валів енкодера і асинхронної машини муфтою спряження під час динамічних вимірювань кутової швидкості протягом перехідного процесу спричиняє похибку взаємодії, що має дві складові: систематичну – періодичну похибку ексцентриситету, і динамічну зумовлену інерційними властивостями муфти. Систематичну періодичну похибку ексцентриситету запропоновано вилучати з результатів вимірювань одним із відомих методів – методом поправок. Динамічну похибку, викликану накладанням перехідного процесу муфти на перехідний процес асинхронної машини, можливо зменшувати застосуванням відповідних спеціалізованих жорстких муфт, що входять до комплекту енкодерів.