bluuebunny/crossref_metadata_2025_split huggingface dataset:
Extracardiac malignancy presenting with cardiac tamponade
Authors: Chen Karl T. K. 
Published: February 2007

AbstractThe clinicopathologic features of a case of cardiac tamponade as the initial presentation of extracardiac malignancy is reported and compared with those of previously reported cases. The lung was the site of the primary tumor in 58% of the cases. Irrespective of the sites of the primary tumor, mediastinal involvement or intrapulmonary metastases or both were documented in 88% of the cases. Examinations of the pericardial fluid and pericardiectomy specimen were negative in a considerable number of cases. Therefore, careful examination of the mediastinum and the accessible lung tissue at the time of pericardiectomy may reveal the malignant nature of the disease which may otherwise remain undiagnosed.
Malignant melanoma in a blind eye
Authors: Sarma Deba P. , Deshotels Seldon J. , Lunseth John H. 
Published: February 2007

AbstractA 62‐year‐old man developed a malignant melanoma in his left eye that had been blind due to trauma for 35 years. This case illustrates the difficulties in detection and early diagnosis of occult malignant melanoma of the uveal tract in phthistic globes. The necessity for long‐term follow‐up of posttraumatic eyes is stressed.
Gastric cancer‐survival at the pennsylvania hospital with and without adjuvant chemotherapy
Authors: Lerner H. , Marcovitz E. , Zaren H. 
Published: February 2007

AbstractFrom 1964 to 1974, 122 patients were treated for gastric cancer; none of these patients received chemotherapy; 13 of this group were lost to follow‐up. In 34 patients, the disease was too far advanced for surgical resection. Their survival ranged from 0.1 month to 7.5 months with a median survival of 1.1 months. Seventy‐four patients were resected for cure; 60 patients underwent a subtotal gastrectomy. Survival ranged from 0 to 72 months with a median of eight months. Fourteen patients had total gastrectomies; survival ranged from 0.1 to 72 months with a median of 5.5 months. Only six of the resected patients had negative lymph nodes; their survival ranged from four to 36 months. In this series there were 11 operative deaths and only seven patients survived five years. Thirty‐one patients who had resections were treated with adjuvant chemotherapy consisting of 0.5 g 5‐fluorouracil.(5‐FU) IV on days 1, 8, 15, etc, and hydroxyurea (HU), 80 mg/kg per os (p.o.), on days 4, 11, 18, etc. This group has a range of survival from three to 164 months and a median survival of 25 months. Fifteen consecutive patients with nonresectable gastric cancer were treated with HU‐FU with a survival of one to 30 months and a median survival of eight months. In patients with measurable disease, objective regression was clearly demonstrated.
Bacterial adherence to bladder tumors in the mouse
Authors: Bagley Demetrius H. , Velanovich Vic , Jones Kenneth W. , Heggers John P. 
Published: February 2007

AbstractMice with intravesical urothelial tumors (MBT‐2) were challenged with E coli inoculated intravesically. Adherence of bacteria measured at 15 min or persistent infection at 24 h was significantly greater in the tumorbearing bladders than in normal non‐tumor‐bearing mice. The tumorbearing portion of the bladder contained significantly more bacteria than the non‐tumor‐bearing portion.
Carcinoma of the anal gland: Case report and review of the literature
Authors: Zaren Howard A. , Delone Francis X. , Lerner Harvey J. 
Published: February 2007

AbstractAnal gland cancer is often insidious in its presentation with no evidence of an intraluminal mass. It is frequently slow‐growing and often thought to be a perirectal or ischiorectal abscess. Repeated incision and drainage is performed until a biopsy reveals the diagnosis. A very wide resection is then necessary to totally remove the tumor.
Adriamycin extravasation: Surgical treatment and possible prevention of skin and soft‐tissue injuries
Authors: Pitkänen Jaakko , Asko‐Seljavaara Sirpa , Gröhn Pentti , Sundell Börje , Heinonen Erkki , Appelqvist Pertti 
Published: February 2007

AbstractIn a material consisting of approximately 6,000 injections of Adriamycin during a 2‐year period, eleven moderate and five severe extravasation injuries have been observed. Even a small leakage of the drug may cause a permanent lesion. The most serious injuries were caused by large doses and on the dorsum of the hand. Plastic surgical operations were successfully performed in the severe cases. An active surgical intervention after primary neutralization of the extravasated Adriamycin is recommended.
Nb rat prostate adenocarcinoma model androgen‐sensitive tumor: Metastasis control
Authors: Drago Joseph R. , Weed Patti , Fralisch Anne 
Published: February 2007

AbstractIn this preliminary report, evaluation of nontraditional agents has been used to evaluate control of metastasis. This androgen‐sensitive rat prostic adenocarcinoma has been subject to the treatments of heparin, indocin, and castration, as well as combinations of castration, heparin, indocin, and cyclophosphamide. Tumor volume, metastasis and determination of regression of primary tumor have been evaluated. Heparin and indocin both reduced metastasis without affecting tumor volume in this study. The combination of castration and cyclophosphamide was most effective in reducing tumor volume when compared to the other groups.
Gut‐associated lymphoid tissue and dimethylhydrazine‐induced colorectal carcinoma in the wistar/furth rat
Authors: Deasy J. M. , Steele G. , Ross D. S. , Lahey S. J. , Wilson R. E. , Madara J. 
Published: February 2007

AbstractAlthough gut‐associated lymphoid tissue in the form of discrete lymphoid patches (LP‐GALT) in mammalian intestine is most prominent in the distal ileum, appendix, and, in some species, the cecal appendage, LP‐GALT can be found throughout the intestinal tract. LP‐GALT appears as single or multiple subepithelial lymphoid follicles covered by a specialized, structurally unique epithelium. In the colon of the Wistar/Furth(W/Fu) rat, LP‐GALT appears as aggregates of follicles, or lymphoid patches, that can be detected macroscopically. We studied the relationship between 1,2‐dimethylhydrazine‐ (DMH) induced colon carcinomas and the lymphoid patch associated epithelium in these animals. In addition, we defined the normal distribution of colonic lymphoid patches in both DMH‐treated and control rats. Patches were found macroscopically and confirmed by histologic examination at five constant sites: lower pole of cecum, proximal ascending colon, the major colonic flexure, mid descending colon, and the rectosigmoid. These are also the predominant sites of DMH induced carcinomas in W/Fu rats. In 120 DMH‐treated animals, 109 colon carcinomas were found. Eight percent were in the lower pole of the cecum, 56% in the proximal ascending colon, 16% at the major flexure, 15% in the mid descending colon, and 5% in the rectosigmoid. Lymphoid patches could often be detected histologically in association with DMH‐induced tumors. The depth of tumor invasion was found to correlate inversely with our ability to identify tumor‐associated lymphoid patches suggesting that tumors arising at the anatomical sites where lymphoid patches occur progressively destroyed them. Of colon tumors confirmed histologically to be associated with lymphoid patches, 88% were superficial lesions confined to the submucosa and 12% were more extensive but confined to the bowel wall. No lymphoid patches could be found associated with tumors that extended through the bowel wall. Thus, DMH‐induced colon carcinomas in W/Fu rats arise at sites containing preexisting LP‐GALT with associated specialized epithelium.
Solitary plasmacytoma
Authors: Kayrouz Thomas , Jose Baby , Chu Ann M. , Scott Ralph M. 
Published: February 2007

AbstractA Retrospective Review Is Presented Of Nine Patients Presenting With Solitary Plasmacytoma. Between 1963 And 1980, These Patients Were Treated With Radiation At The Department Of Radiation Oncology, University Of Louisville. Criteria For Admission To This Particular Study Include (1) A Solitary Focus Of Plasmacytoma Proven By Biopsy, (2) Normal Bone Marrow Findings (Less Than 10% Plasma Cells), And (3) No Evidence Of Disseminated Disease. In Six Patients The Primary Site Was Osseous, And In Three Extramedullary, Two Of Which Were Located In The Nasopharynx And Nasal Cavity And The Third In The Stomach. All Of The Extramedullary Plasmacytomas Are Disease Free For Periods Ranging From 4 To 10 Years. Of The Six Patients With Osseous Lesions, Two Developed Multiple Myeloma In 2 And 3 Years, Two Are Ned (No Evidence Of Disorder) After 9 Years, One Died Of Intercurrent Disease, And The Remaining Patient Was Ned For 2 Years, After Which He Was Lost To Follow‐Up. These Results Suggest The More Favorable Prognosis Of Extramedullary Plasmacytoma And Support The Theory That The Solitary Plasmacytoma Of Bone And Extramedullary Plasmacytoma Are Distinct Disease Entities.
Myosarcomas of the small and large intestine: A clinicopathologic study
Authors: Shiu Man H. , Farr Gist H. , Egeli Ruedi A. , Quan Stuart H. G. , Hajdu Steven I. 
Published: February 2007

AbstractA retrospective study was made of 38 myosarcomas of the small and large intestines (34 leiomyosarcomas and 4 malignant leiomyoblastomas). Endoenteric, small, and noninvasive tumors were successfully treated by simple wedge excision, cautery snare removal, or segmental bowel resection with a high 5‐yr cure rate of 86% (12/14). Exo‐enteric tumors often invaded adjacent structures or perforated into the peritoneal cavity. Extensive resection procedures, including pancreaticoduodenectomy, abdominoperineal resection, and pelvic exenteration salvaged only 13% (2/16) of these patients. Three clinicopathologic factors adversely affected prognosis: i(tumor size greater than 5 cm in diameter, ii) extra‐intestinal invasion or free perforation, and iii high histopathologic grade of malignancy. The presence of none, one, two, or three of these adverse factors gave decreasing 5‐yr survival rates of 100, 44, 31, and 0%, respectively. These observations suggest use of a multimodal treatment program that may minimize treatment failure from local as well as distant disease.
Ciliated cutaneous cyst of the foot
Authors: Ross Alan J. , Schwartz Robert Allen 
Published: February 2007

AbstractWe report a 36‐year‐old woman with a cutaneous cyst of the dorsal aspect of the left foot. Because of the symptoms of pain and paresthesias attributed to the lesion, it was clinically felt to be a ganglion. After excision, these symptoms abated. Yet histologic examination showed this lesion to be a rare tumor, the ciliated cutaneous cyst. This is the third patient with this distinctive lesion on the foot or ankle.
Dermatomyositis and multiple malignancies in a patient treated with methotrexate
Authors: Callen Jeffrey P. 
Published: February 2007

AbstractDermatomyositis (DM) has been linked to internal malignancy but this relationship is quite variable in respect to tumor type and time sequence. The occurrence of multiple cancers in an individual with DM is rare. Immunosuppressive agents, particularly methotrexate have been used increasingly in corticosteroid resistant cases or for their corticosteroid sparing effects. These agents have not been implicated in the development of malignancy in patients with DM. A patient with a uterine adenocarcinoma developed DM that despite tumor removal was not responsive to corticosteroids. She was successfully treated with methotrexate for 18 months. She has subsequently developed an adenocarcinoma of the breast. The relationship of malignancy and DM as well as the role of methotrexate in the development of the second primary will be discussed.
Unknown primary melanoma
Authors: Klausner Joseph M. , Gutman Moti , Inbar Moshe , Rozin Roland R. 
Published: February 2007

AbstractOf 230 Melanoma Patients Treated During The Past 8 Years, 12 (5.2%) Were Found To Have Unknown Primary Lesions. Nine Of These “Unknown Primary Melanoma” Patients Presented With Metastases In Regional Lymph Nodes, One Inside The Parotid Gland, And Two Presented With Disseminated Melanoma And No Detectable Primary Tumor. The Patients With Melanoma Confined To A Regional Lymph Node Underwent Block Dissection Followed By Adjuvant Chemotherapy And Immunotherapy. Four Patients With Metastasis In Only One Lymph Node Are Disease Free 4–6 Years After Diagnosis. One Patient With Multiple Metastases In The Groin Is Alive 8 Years After Lymphadenectomy. The Other Five Patients With Metastases In Multiple Regional Lymph Node Died 16 Months To 3 Years After Surgery. Both Patients With Disseminated Melanoma Succumbed To Their Disease Within A Month Of Diagnosis. The Prognosis Of Unknown Primary Melanoma Seems To Be No Worse Than The Typical Melanoma At The Same Stage. This Justifies The Aggressive Surgical Approach To This Unusual Entity Of Melanoma.
Evaluation of serum prostate‐specific antigen in urologic cancers
Authors: Takeuchi Toshimi , Kuriyama Manabu , Fujihiro Shigeru , Fujimoto Yoshinori , Okano Manabu , Nishiura Tsuneo 
Published: February 2007

AbstractSerum prostate‐specific antigen (PA), a new tumor marker of prostate cancer, was evaluated with an enzyme immunoassay (EIA) in various urologic cancer patients and benign prostatic diseases in Japanese. Sera of prostate cancer patients before treatment (n = 27) revealed a range of PA concentrations from 0.12‐23 ng/ml with a mean (± SD) of 5.78 ± 6.85 ng/ml, while that of patients with benign prostatic hypertrophy (BPH) (n = 27) showed from less than 0.10 to 2.6 ng/ml with 0.84 ± 0.81 ng/ml (mean ± SD). The mean serum PA levels in nonprostatic cancers were calculated as follows: bladder cancer (n = 21), 0.77 ± 0.55 ng/ml; renal pelvis or ureteral cancer (n = 6), 0.46 ± 0.47 ng/ml; renal adenocarcinoma (n = 6), 1.07 ± 0.77 ng/ml; other urologic cancers (n = 6), 0.55 ± 0.52 ng/ml. Serum PA ranged from less than 0.10 to 1.1 ng/ml in patients with prostatitis (n = 5). A significant statistical difference in serum PA levels between prostate cancer and other groups was recognized. These results suggested that an elevation of serum PA value was highly specific to prostate cancer in urological malignancies. The evaluation of serum PA may be of great value in the detection of prostate cancer.
Pelvic exenteration combined with sacral resection for recurrent rectal cancer
Authors: Takagi Hiroshi , Morimoto Takeshi , Kato Tomoyuki , Yasue Mitsunori , Endo Tokiko , Suzuki Ryoji 
Published: February 2007

AbstractLocal recurrence of rectal cancer following abdominoperineal resection is rarely amenable to limited resection. Computed tomographic (CT) study of the pelvis revealed recurrent tumor images in relation to the adjacent pelvic structures. Five patients with deeply invading recurrent lesions were submitted to pelvic exenteration combined with sacral resection. No postoperative deaths were encountered. The postoperative sharp drops of serum CEA levels are useful for judging the adequacy of this procedure. The follow‐up status of the 5 patients, respectively: 14 months alive with pulmonary metastasis, 9 months alive without symptoms but with slightly elevated CEA levels, and 8 months, 3 months, and 3 weeks alive with no evidence of disease. All patients who were relieved of perineal or sciatic nerve pain are now able to walk without any assistance or trouble. Total en bloc residual pelvic exenteration combined with sacral resection is a reasonable treatment for locally recurrent rectal cancer.
Estrogen receptor profile of patients with breast cancer metastatic to bone marrow
Authors: Budd G. Thomas 
Published: February 2007

AbstractThe estrogen receptor (ER) profile of patients with breast cancer metastatic to bone marrow (BM) has not been widely reported. The charts of all patients having a diagnosis of breast cancer and undergoing bone marrow aspiration or biopsy at the Cleveland Clinic during the period of January 1980 through September 1982 were reviewed. Thirty‐nine patients were so identified; of these 39 patients, 28 had estrogen receptor determination performed on a primary or a metastatic tumor specimen. Of the 28 patients with known ER, ten (36%) had ER less than 5 fmoles/mg cytosol protein, three (11%) had ER or 5 to 10 fmoles/mg, and 15 (54%) had ER greater than 10 fmoles/mg. Of the 39 patients with BM involvement, 36 (92%) had cortical bone involvement documented on x‐ray or isotopic bone scan. Liver involvement was documented in 6/34 (18%) patients, pulmonary involvement in 14/37 (38%) patients, CNS relapses in 3/39 (8%), and locoregional recurrences in 19/39 (49%). The most significant hematologic finding was a hemoglobin of less than 12 gm% in 21/37 (57%). The most frequent biochemical abnormality was an elevation of the alkaline phosphatase in 30/39 (77%). The majority of breast cancer patients have a positive ER and ER‐positive breast cancer has a tendency to metastasize to cortical bone. Bone marrow involvement by breast cancer is closely associated with cortical bone involvement; accordingly, bone marrow metastases are often associated with a positive ER.
Paraneoplastic syndromes with soft‐tissue sarcoma: A report of two unusual cases
Authors: Bertelsen Carl A. , Eilber Frederick R. 
Published: February 2007

AbstractParaneoplastic syndromes secondary to mesodermal tumors are relatively uncommon. In this report, we describe two unusual cases associated with soft‐tissue sarcoma: a 69‐year‐old male who had a normochromic anemia, without apparent etiology, that resolved promptly after surgical resection of the primary tumor; and a 22‐year‐old female with hypercalcemia without evidence of bony destruction.
Leiomyosarcoma of the rectum: Report of three cases
Authors: Stair J. Michael , Stevenson D. Richard , Schaefer Robert F. , Lang Nicholas P. 
Published: February 2007

AbstractLeiomyosarcoma is a malignant tumor which rarely occurs in the rectum. Three patients with leiomyosarcoma of the rectum are presented. Treatment should include wide surgical excision followed by adjuvant chemotherapy. Emphasis is placed upon computerized tomography as the method of choice for the diagnosis of recurrent disease. Recurrent tumor should be resected whenever possible.
Pedunculated malignant melanoma of the hard palate
Authors: Zirkin Howard J. , Avinoach Ilana , Puterman Marco 
Published: February 2007

AbstractWe report the case of a primary malignant melanoma arising from the mucosa of the hard palate on a fibrovascular stalk. This is to our knowledge the first report of a pedunculated melanoma in this location. The possibility of a more favorable prognosis, because of the stalk, which shows no signs of invasion by the neoplasm, is considered.
Induction of colon mucosal β‐glucuronidase production as a mechanism for 1,2‐dimethylhydrazine colon carcinogenesis
Authors: Celik Cihangir , Lewis David A. , Mittleman Arnold 
Published: February 2007

AbstractAlthough early studies in germ‐free rats showed almost complete dependence on dimethylhydrazine (DMH) colon carcinogenesis upon the presence of colon bacteria, no adequate explanation was given for the 20% tumor incidence observed in germ‐free animals. Bacterial activation of liver microsomal products releasing active proximate carcinogens has been the accepted reason for the exquisite specificity DMH has for the colon. Recent work, including the present study, show the colon mucosa is capable of metabolizing carcinogens and activating conjugating forms metabolized in the liver independent of the intestinal microflora. Mucosal β‐glucuronidase production was assayed in coded, scraped mucosa samples from the duodenum/jejunum, ileum, right colon, and left colon of normal and DMH‐treated rats. Normal mucosal β‐glucuronidase production was highest in the left colon followed by the right colon, duodenum, and ileum, respectively. Enzyme production in the left colon was significantly increased 24 hours after injection of 25 mg/kg body weight DMH. No elevation was seen in other mucosal samples. Metabolism of DMH to oxidated forms conjugated to glucuronic acid is well established. Thus, this study offers a possible role for carcinogen, induction of a metabolic enzyme in its target tissue.
Teaching surgical oncology to medical studients
Authors: Jewell William R. , Deslauriers Marc P. 
Published: February 2007

AbstractA Recent Review Of The Curriculum At University Of Kansas Medical Center‐Kansas City Revealed Several Deficiencies In Oncology Teaching In The Medical School Curriculum. Analysis Of The Surgery Core Course Final Examination Showed A Weaker Response By Students To Surgical Oncology Items Than Nononcologic Questions. A Multidisciplinary Cancer Course And Tumor Conference Were Then Added To The Surgery Core Curriculum. Analysis Of Student Performance Since This Addition Reveals That The Multimodal Course Improved The Successful Response Rate To Surgical Oncology Questions On The Final Examination. This Effect Has Been Sustained Through Nine Consecutive Student Group Rotations. These Results Suggest That Surgical Oncology Teaching Can Be Effectively Improved By A Multidisciplinary Effort.
The role of the tissue adhesive fibrin seal (FS) in esophageal anastomoses
Authors: Thorson G. K. , Perez‐Brett R. , Lillie D. B. , Ambrus J. L. , Karakousis C. , Takita H. , Williams P. D. , Reddington M. M. , Cohen H. 
Published: February 2007

AbstractFollowing Surgical Removal Of Esophageal Tumors, Leakage And Medistinitis Is A Frequent And Often Fatal Complication. A New Method Has Been Developed To Seal Suture Lines In The Esophagus With Preparations Containing Fibrinogen, Cold Insoluble Globulin, Factor Xiii, Antiplasmin, Platelet Growth Factor, Thrombin, And Calcium Chloride. In Experimental Animals Operated On By Standard Methods, Esophageal Leakage Developed In 50% Of The Animals And Death In 40%. By Contrast, In Treated Animals, Esophageal Leak And Death Developed In Only 20%. More Adhesions Were Found In Treated Animals Than In Control Animals.
Antibody‐dependent cellular cytotoxicity (ADCC) in colorectal carcinoma. I. Favorable prognosis in female patients
Authors: Pihl E. , Nairn R. C. , Nind A. P. P. , Jones S. L. , Chalmers P. J. , Pullen G. R. , Hughes E. S. R. , Cuthbertson A. M. 
Published: February 2007

AbstractIn an immunological study of 288 colorectal carcinoma patients, we investigated the relationship between survival and preoperative in vitro antibody‐dependent cellular cytotoxicity (ADCC) against the colonic carcinoma cell line HT‐29. A highly significantly favorable (p = 0.001) association was found in the 20 female patients with ADCC. Nearly all (97%) of the 66 patients with ADCC were blood group O, but blood group per se did not relate to survival, nor could staging explain the survival association with ADCC. The mechanism whereby ADCC or its in vivo expression confers a survival advantage is unknown but we suggest that it derives from immunoreactivity against blood group A antigens produced inappropriately in the carcinomatous epithelium of the group O and B patients.
Antibody‐dependent cellular cytotoxicity (ADCC) in colorectal carcinoma. II. Blood group association
Authors: Jones S. L. , Pihl E. , Nind A. P. P. , Chalmers P. J. , Nairn R. C. 
Published: February 2007

AbstractColorectal carcinoma patients' sera with ADCC antibody reacting with the HT‐29 cell line (blood group A) generally (88%) cross‐reacted with another group A cell line (COLO‐394) but much less frequently (6–33%), with six tumor cell lines that did not express ABO blood group antigens. The findings suggested the possibility that the ADCC reactivity against the HT‐29 cell line particularly by patients of blood group O is generally via “A” or “A‐like” antigenicity of the target cells. This was supported by absorption studies that showed that the ADCC reactivity could be removed by blood group A but never by group B erythrocytes. Our results suggest that the prognostically favorable ADCC antibody in colorectal carcinoma patients' sera is of anti–blood group A specificity or cross reactivity.