bluuebunny/crossref_metadata_2025_split huggingface dataset:
Raya Hisar 1706: An Indian Mustard Variety with Low Erucic Acid
Authors: Kumari Nisha , Avtar Ram , Kumar Neeraj , Goyal Vinod , Punia Rakesh , Kumar Dalip , Shweta  , Bishnoi Mahavir , Singh Rajbir 
Published: February 2025

Raya Hisar 1706 (RH 1706), the first zero erucic acid (erucic acid <2%) Indian mustard [Brassica juncea (L.) Czern & Coss] variety in public sector developed by Chaudhary Charan Singh Haryana Agricultural University, Hisar, Haryana. It was released for commercial cultivation in 2023. It is black seeded with 38.0% oil content. In Indian mustard varieties erucic acid (C:22) is a major (40-50%) fatty acid. The mustard oil is considered as antinutritional due to the presence of erucic acid as main component, as it has been concern with heart health. T variety RH 1706 has been developed with the objectives to get higher seed and oil yield with low erucic acid content under irrigated conditions by crossing NOID X EC-597324 and subsequently hybridization followed by pedigree method of selection. The NOID (RC-187) is a low erucic acid germplasm being maintained at Hisar and EC-597324 is an exotic line and a good combiner parent having desired component traits like siliqua density, number of seeds/siliqua etc. Single plants of medium duration, profuse branching with low erucic acid in oil was selected using pedigree selection method in the segregating generations during generation advancement. After F6 generation, uniform advance lines having low erucic acid characteristics, more than 38% oil content, numerically at par or better for seed yield with the best checks were retained for further evaluation in replicated trials. The superior bulks were evaluated in a station trial, initial variety trial (IVT), advance variety trial-I (AVT-I), advance variety trial-II (AVT-II), and the RH 1706 was found better in seed yield than the checks viz PM-29, RH 0749 and Kranti.
Sensory Evaluation of Rasmalai Blended with Sweet Potato (Ipomoea batatas L.) Pulp
Authors: Patil V. N. , Dandekar V.S. , Terde S.H. , Mayekar A. J. , Kasture M.C. , Khandekar R.G. , V.B.Kadav  , N.N.Prasade  , Ramod S. S. 
Published: February 2025

Aims: Nutritional benefits of sweet potato blended into Rasmalai was explored in this study by developing a value-added Rasmalai. This work aimed to facilitate utilization of sweet potato pulp not only increases nutritive value of product but also improved sensory quality. This study finds out optimum level of sweet potato pulp in Rasogolla part of Rasmalai with two sugar level in concentrated milk.
Study Design: This research was experimental and performed in a laboratory.
Place and Duration of Study: This study was conducted at Department of Animal Husbandry and Dairy Science, College of Agriculture, Dr.BSKKV, Dapoli Maharashtra , India, during 2022-23.
Methodology: The Rasmalai was prepared from cow and buffalo milk by incorporating sweet potato pulp @ 0%(T0),5% (T1), 10% (T2), and 15 % (T3) in Rasogolla part and two sugar level i.e. 7% (S1) and 8% (S2) in concentrated milk based on weight of Chhana and initial milk respectively. All treatments were analyzed for sensory attributes i.e colour and appearance, body and texture, flavour and overall acceptability by using 9-point Hedonic scale. Research Conducted with Five Replication.
Results: Most optimum level of sweet potato pulp @10 % found in Rasmalai with 7 and 8 percent sugar level had obtaining maximum score for colour and appearance (8.18 and 8.18) and, body and texture (8.34 and 8.28), flavour (8.34 and 8.50) and overall acceptability (8.54 and 8.58) respectively.The statistical analysis of the data shows that the impact of sweet potato pulp was significant at the 1% level of probability, but the effect of sugar and the interaction effect of sugar X SPP were non-significant.
Conclusion: The study concludes that incorporating up to 15% sweet potato pulp in Rasmalai can improve its sensory characteristics without compromising its traditional appeal, offering a nutritious twist to the dessert. The most acceptable quality Rasmalai can be prepared by using 10% SPP with both sugar level.
Evaluation of Physico-chemical Parameters of Selected Clotrimazole Pessaries from Pharmaceutical Importers and Accredited Drug Dispensing Outlets in Dar es Salaam, Tanzania
Authors: Brashi Benedict , Mlugu Eulambius M. , Kaale Eliangiringa A. 
Published: February 2025

Introduction: Quality assured medicines make an important contribution to a global reduction in morbidity and mortality. Tanzania imports approximately 70% of its medicines, some of which are manufactured in countries with different climatic conditions that may affect their stability. The prevalence of vaginal candidiasis amongst women seeking primary health care for genital infections in Dar es Salaam is 45%. Clotrimazole pessaries is the first-line drug for the treatment of vaginal candidiasis (VC). However, there are reports showing the existence of poor quality clotrimazole in the market as well as microbial resistance.
Study Objectives: This study aimed to assess the quality of clotrimazole pessaries among pharmaceutical importers and Accredited Drug Dispensing Outlets (ADDOs) outlets in Dar es Salaam.
Methods: The experimental study laboratory-based was conducted between October 2021 to July 2022. A total of 72 samples, 5 from pharmaceutical importers and 67 from ADDO outlets, were collected by mystery clients through the convenient method. Assay for the content of active ingredients and disintegration time were performed as described in the British Pharmacopoeia (BP).
Results: All samples passed the physical inspection and disintegration test. Among the collected samples, two of 72(2.78%) failed the assay test. The assay for an active pharmaceutical ingredient for samples from importers was significantly greater than that from ADDO outlets.
Conclusion: Storage conditions may affect the drug content of clotrimazole pessaries. A few samples from ADDO without fan failed to meet the assay test as per British Pharmacopeia specification.
Recommendations: The Pharmacy Regulation 2019, for Accredited Drugs, Dispensing Outlets, Standards, and Ethics for Dispensation of Medicines to be revitalized to include specification on ADDO outlets regarding the storage conditions to align with the pharmaceutical manufacturer’s recommendations. Also, regulatory inspections should be emphasized by the Regulatory Authority including Pharmacy Council and TMDA so as to ensure the registered pharmaceutical outlets continue complying with standards required like the presence of air conditions so that the medicines continue to be of desired quality throughout their shelf life.
Transitions of care: Assessment of adherence to long-acting injectable antipsychotic treatment following discharge from inpatient psychiatry
Authors: Ross Charnae , Adams Katie S. , Crouse Ericka L. 
Published: February 2025

Abstract
Introduction: Long-acting injectable antipsychotics (LAI-APs) are used in patients with chronic psychiatric disorders as a strategy to manage oral medication nonadherence. Inpatient LAI-AP administration may assist with transition to the outpatient setting. The study objective was to characterize receipt of the next LAI-AP injection as planned in the outpatient setting following administration during inpatient psychiatric hospitalization.
Methods: Patients 18 years and older were eligible for inclusion if they received an LAI-AP while inpatient and provided consent to monitor their 90-day follow-up. The primary outcome determined the percentage of patients who received the same LAI-AP administered during their inpatient psychiatric admission at their initial visit post discharge. The secondary outcomes compared appropriate documentation of the LAI-AP follow-up plan, oral overlap, and early psychiatric rehospitalization rates.
Results: Fifty-one patients were included. Twenty-nine patients (56.9%) followed up within the outpatient setting after discharge and received their next scheduled LAI-AP as planned. Twenty-two patients (43.1%) did not receive an LAI-AP injection following discharge, 15 of whom did not attend their initial follow-up appointment. Thirty-nine patients (76.5%) were newly initiated on LAI-AP therapy, 19 of whom received their next follow-up injection.
Discussion: More than 40% of patients who received an LAI-AP inpatient did not follow up in the outpatient setting despite appropriate discharge planning. Patients more likely to receive follow-up LAI-AP were older, received a maintenance injection while inpatient, and had a scheduled follow-up appointment. Prior to inpatient administration of LAI-AP, multiple factors should be considered, including outpatient adherence, access, feasibility of outpatient continuation, and transition of care plan.
Pharmacist administration of long-acting injectable medications for substance use disorders: A scoping review
Authors: Hernandez Bustamante Pamela , Charles Amanda , Snider Marissa , Catanzano Samantha 
Published: February 2025

Abstract
Introduction: Using long-acting injectable (LAI) medications increases treatment adherence and promotes positive outcomes for patients with substance use disorders (SUD). Despite documented benefits that LAI medications can have over their oral counterparts, they continue to be underused. With the expansion of pharmacists’ scope of practice for medication administration services, there is a need to document and evaluate the benefits of pharmacist engagement in LAI administration services for SUD and identify growth opportunities.
Methods: A PubMed database search for articles related to a pharmacist’s role in LAI administration services for buprenorphine and naltrexone was conducted. Articles published before December 15, 2023, and in English describing or reporting outcomes of pharmacists administering LAI buprenorphine or LAI naltrexone in the United States were included.
Results: A total of 56 articles were identified in the search process. After removing duplicate citations and exploring references and similar article recommendations, a total of 5 articles were included in the final analysis. All 5 articles discussed pharmacist administration of LAI naltrexone, and no articles discussed pharmacist administration of LAI buprenorphine. Outcomes for each article varied and included cost analyses, implementation procedures, and identified barriers.
Discussion: Current literature on pharmacist-administered LAI services is limited. With many states allowing pharmacist administration of LAI medications, there is a significant opportunity to expand patient access to LAI medications for SUD in the pharmacy setting. Standardized training on LAI administration, development of standard operating procedures, and clarity on reimbursement policies are needed to help accelerate the implementation of pharmacist-administered LAI services.
Provision of Medications for Self-Managed Abortion Before and After the Dobbs v Jackson Women’s Health Organization Decision
Authors: Aiken Abigail R. A. , Wells Elisa S. , Gomperts Rebecca , Scott James G. 
Published: March 2024

ImportanceThe Supreme Court decision in Dobbs v Jackson Women’s Health Organization overturned the right to choose abortion in the US, with at least 16 states subsequently implementing abortion bans or 6-week gestational limits. Prior research indicates that in the 6 months following Dobbs, approximately 32 360 fewer abortions were provided within the US formal health care setting. However, trends in the provision of medications for self-managed abortion outside the formal health care setting have not been studied.ObjectiveTo determine whether the provision of medications for self-managed abortion outside the formal health care setting increased in the 6 months after Dobbs.Design, Setting, and ParticipantsCross-sectional study using data from sources that provided abortion medications outside the formal health care setting to people in the US between March 1 and December 31, 2022, including online telemedicine organizations, community networks, and online vendors. Using a hierarchical bayesian model, we imputed missing values from sources not providing data. We estimated the change in provision of medications for self-managed abortion after the Dobbs decision. We then estimated actual use of these medications by accounting for the possibility that not all provided medications are used by recipients.ExposureAbortion restrictions following the Dobbs decision.Main Outcomes and MeasuresProvision and use of medications for a self-managed abortion.ResultsIn the 6-month post-Dobbs period (July 1 to December 31, 2022), the total number of provisions of medications for self-managed abortion increased by 27 838 (95% credible interval [CrI], 26 374-29 175) vs what would have been expected based on pre-Dobbs levels. Excluding imputed data changes the results only slightly (27 145; 95% CrI, 25 747-28 246). Accounting for nonuse of medications, actual self-managed medication abortions increased by an estimated 26 055 (95% CrI, 24 739-27 245) vs what would have been expected had the Dobbs decision not occurred.Conclusions and RelevanceProvision of medications for self-managed abortions increased in the 6 months following the Dobbs decision. Results suggest that a substantial number of abortion seekers accessed services despite the implementation of state-level bans and restrictions.
Emergency Department Peer Support Program and Patient Outcomes After Opioid Overdose
Authors: Treitler Peter , Crystal Stephen , Cantor Joel , Chakravarty Sujoy , Kline Anna , Morton Cory , Powell Kristen Gilmore , Borys Suzanne , Cooperman Nina A. 
Published: March 2024

ImportancePatients treated in emergency departments (EDs) for opioid overdose often need drug treatment yet are rarely linked to services after discharge. Emergency department–based peer support is a promising approach for promoting treatment linkage, but evidence of its effectiveness is lacking.ObjectiveTo examine the association of the Opioid Overdose Recovery Program (OORP), an ED peer recovery support service, with postdischarge addiction treatment initiation, repeat overdose, and acute care utilization.Design, Setting, and ParticipantsThis intention-to-treat retrospective cohort study used 2014 to 2020 New Jersey Medicaid data for Medicaid enrollees aged 18 to 64 years who were treated for nonfatal opioid overdose from January 2015 to June 2020 at 70 New Jersey acute care hospitals. Data were analyzed from August 2022 to November 2023.ExposureHospital OORP implementation.Main Outcomes and MeasuresThe primary outcome was medication for opioid use disorder (MOUD) initiation within 60 days of discharge. Secondary outcomes included psychosocial treatment initiation, medically treated drug overdoses, and all-cause acute care visits after discharge. An event study design was used to compare 180-day outcomes between patients treated in OORP hospitals and those treated in non-OORP hospitals. Analyses adjusted for patient demographics, comorbidities, and prior service use and for community-level sociodemographics and drug treatment access.ResultsA total of 12 046 individuals were included in the study (62.0% male). Preimplementation outcome trends were similar for patients treated in OORP and non-OORP hospitals. Implementation of the OORP was associated with an increase of 0.034 (95% CI, 0.004-0.064) in the probability of 60-day MOUD initiation in the half-year after implementation, representing a 45% increase above the preimplementation mean probability of 0.075 (95% CI, 0.066-0.084). Program implementation was associated with fewer repeat medically treated overdoses 4 half-years (−0.086; 95% CI, −0.154 to −0.018) and 5 half-years (−0.106; 95% CI, −0.184 to −0.028) after implementation. Results differed slightly depending on the reference period used, and hospital-specific models showed substantial heterogeneity in program outcomes across facilities.Conclusions and RelevanceIn this cohort study of patients treated for opioid overdose, OORP implementation was associated with an increase in MOUD initiation and a decrease in repeat medically treated overdoses. The large variation in outcomes across hospitals suggests that treatment effects were heterogeneous and may depend on factors such as implementation success, program embeddedness, and availability of other hospital- and community-based OUD services.
Trends in Intracranial and Cerebral Volumes of Framingham Heart Study Participants Born 1930 to 1970
Authors: DeCarli Charles , Maillard Pauline , Pase Matthew P. , Beiser Alexa S. , Kojis Daniel , Satizabal Claudia L. , Himali Jayandra J. , Aparicio Hugo J. , Fletcher Evan , Seshadri Sudha 
Published: March 2024

ImportanceHuman brain development and maintenance is under both genetic and environmental influences that likely affect later-life dementia risk.ObjectiveTo examine environmental influences by testing whether time-dependent secular differences occurred in cranial and brain volumes and cortical thickness over birth decades spanning 1930 to 1970.Design, Setting, and ParticipantsThis cross-sectional study used data from the community-based Framingham Heart Study cohort for participants born in the decades 1930 to 1970. Participants did not have dementia or history of stroke and had magnetic resonance imaging (MRI) obtained from March 18, 1999, to November 15, 2019. The final analysis dataset was created in October 2023.ExposureYears of birth ranging from 1925 to 1968.Main MeasuresCross-sectional analysis of intracranial, cortical gray matter, white matter, and hippocampal volumes as well as cortical surface area and cortical thickness. The secular measure was the decade in which the participant was born. Covariates included age at MRI and sex.ResultsThe main study cohort consisted of 3226 participants with a mean (SD) age of 57.7 (7.8) years at the time of their MRI. A total of 1706 participants were female (53%) and 1520 (47%) were male. The birth decades ranged from the 1930s to 1970s. Significant trends for larger intracranial, hippocampal, and white matter volumes and cortical surface area were associated with progressive birth decades. Comparing the 1930s birth decade to the 1970s accounted for a 6.6% greater volume (1234 mL; 95% CI, 1220-1248, vs 1321 mL; 95% CI, 1301-1341) for ICV, 7.7% greater volume (441.9 mL; 95% CI, 435.2-448.5, vs 476.3 mL; 95% CI, 467.0-485.7) for white matter, 5.7% greater value (6.51 mL; 95% CI, 6.42-6.60, vs 6.89 mL; 95% CI, 6.77-7.02) for hippocampal volume, and a 14.9% greater value (1933 cm2; 95% CI, 1908-1959, vs 2222 cm2; 95% CI, 2186-2259) for cortical surface area. Repeat analysis applied to a subgroup of 1145 individuals of similar age range born in the 1940s (mean [SD] age, 60.0 [2.8] years) and 1950s (mean [SD] age, 59.0 [2.8] years) resulted in similar findings.Conclusion and RelevanceIn this study, secular trends for larger brain volumes suggested improved brain development among individuals born between 1930 and 1970. Early life environmental influences may explain these results and contribute to the declining dementia incidence previously reported in the Framingham Heart Study cohort.
Workspace for female telecommuters living in an urban apartment house with children
Authors: Matsushita Daisuke 
Published: March 2024

AbstractWFH‐related issues regarding house planning, spatial arrangements, and relationships among cohabitants for sharing spaces remain to be clarified. This research aimed to clarify the usage patterns of shared spaces for work‐from‐home (WFH) and the respective behavioral patterns in different household compositions, targeting women in the child‐rearing stage and residing with family in residential building estates in urban areas. Forty‐four percent (n = 199) of women performing childcare who regularly telecommuted had a spouse or partner who also telecommuted, and 65.6% (n = 328) had a child at home while telecommuting. Male spouses or partners (male) did less than half of the housework (12.7%) and childcare (19.8%) than women (41.0% housework, 34.4% childcare). Women primarily used dining rooms for office work (n = 221; 44.2%). When the children were at home during telecommuting, the unclear distinction between work and home was not a deficiency but rather an inevitable acceptance, and a tendency to work in a corner overlooking the common area was observed. When both spouses telecommute without children, men work in their bedrooms or private rooms, whereas women work in common areas, such as the dining room. Simultaneously, women tended to seek spaces dedicated to their work and keep their workspaces separate from common area.
Patient‐Reported Sinonasal Symptoms and Risk of Relapse in Antineutrophil Cytoplasmic Antibody–Associated Vasculitis
Authors: Romich Ellen , Banerjee Shubhasree , Amudala Naomi , Chou Sherry , Li Ruolan , Lee Hongzhe , Cohen Noam , Merkel Peter A. , Rhee Rennie L. 
Published: March 2024

ObjectiveRelapses are frequent and difficult to predict in antineutrophil cytoplasmic antibody–associated vasculitis (AAV), resulting in long‐term use of immunosuppression. Although sinonasal disease is associated with relapse of AAV, detailed characterization of sinonasal symptoms is lacking. Using a patient‐reported outcome, the 22‐item SinoNasal Outcome Test (SNOT‐22), we investigated the relationship between sinonasal symptoms and disease activity in AAV.MethodsThis was a prospective, longitudinal study of individual with AAV and healthy individuals. Relapse was defined as a Birmingham Vasculitis Activity Score for Wegner's Granulomatosis score >0. Higher SNOT‐22 scores indicate worse symptoms. Generalized estimating equation and Cox proportional hazard models evaluated the association between SNOT‐22 and relapse.ResultsThere were 773 visits (106 active disease visits) from 168 patients with AAV and 51 controls. Median SNOT‐22 at remission was higher in AAV versus controls (20 vs 5; P < 0.001) and higher during active disease versus remission (P < 0.001). In all AAV, and particularly within granulomatosis with polyangiitis, higher SNOT‐22 scores were observed months to years before relapse and were associated with increased risk of relapse (hazard ratio 2.7, 95% confidence interval 1.2–6.2; P = 0.02). Similar findings were seen when examining patients with versus without sinonasal disease and after removing relapses limited to the ear, nose, and throat.ConclusionA patient‐reported outcome measure of sinonasal disease, the SNOT‐22, not only changes with disease activity in AAV, but also is associated with a higher risk of relapse within two years. These findings support the possibility that the SNOT‐22 score may enhance prediction of relapse and that persistent sinonasal disease may be important in the pathophysiology of relapse.