bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating the contribution of the Glittre‐ADL test in adults with cystic fibrosis
Authors: Abelenda Vera Lucia Barros , da Costa Cláudia Henrique , Firmida Mônica de Cássia , Lopes Agnaldo José 
Published: March 2024

AbstractBackground and ObjectivesCardiopulmonary and skeletal muscle impairment and poor physical activity are potential contributors to reduced functional capacity in cystic fibrosis (CF). The Glittre‐ADL test (TGlittre) has great potential for clinical use in adult CF adults, as it meets the need for a comprehensive assessment of physical function using tasks similar to activities of daily living. This study aimed to evaluate the performance of TGlittre in CF adults compared to the 6‐min walk test (6MWT) and, secondarily, to quantify the associations of their results with pulmonary function, muscle strength, and health‐related quality of life (HRQoL).MethodsThis cross‐sectional study evaluated 34 CF adults and compared them with 34 subjects from a control group. The participants underwent the following assessments: functional capacity using TGlittre and 6MWT; spirometry; respiratory muscle strength; handgrip strength (HGS); and HRQoL using the Cystic Fibrosis Questionnaire‐Revised (CFQ‐R).ResultsWhile CF patients showed a longer time to perform TGlittre compared to controls (134 (119–150) versus 107 (95–126) % of the predicted time p = 0.0002), no difference between these groups was observed in the 6MWT. When the second TGlittre was compared to the first TGlittre, there was a significant decrease in total time for both CF patients (p < 0.0001) and controls (p = 0.0001). TGlittre time correlated with 6MWT distance (6MWD) (rs = −0.641, p < 0.0001), HGS (rs = −0.364, p = 0.034), peripheral oxygen saturation at the end of the test (rs = −0.463, p = 0.006) and the “digestive symptoms” domain of CFQ‐R (rs = 0.376, p = 0.028). TGlittre time was shorter in patients who engaged in regular physical activity (3.10 (2.49–3.39) min versus 3.28 (2.95–3.53) min, p = 0.016).ConclusionsTGlittre is more effective than the 6MWT in detecting limitations during exercise. There is an important learning effect of TGlittre in adult CF patients. TGlittre time was correlated with 6MWD, HGS, oxygen saturation level, and the patient's level of physical activity.
Orographic gravity‐wave drag over multiple bell‐shaped mountains
Authors: Kwon Ui‐Jin , Park Sungsu 
Published: March 2024

AbstractMountains exert a drag on the atmospheric flow through breaking gravity waves, known as orographic gravity‐wave drag (OGWD). This article presents a theoretical analysis of the impacts and limitations of missing processes in current parameterization schemes for OGWD and examines the significance of various approximations. We derive OGWD analytically for multiple three‐dimensional bell‐shaped mountains, while previous studies have derived OGWD for a single three‐dimensional elliptic mountain. We take into account the geometric overlap between the mountains, vertical shear of the horizontal wind, nonhydrostatic atmosphere, and Coriolis forces. Our findings show that OGWD depends on the direction of the incoming wind and the degree of overlap between two mountains. OGWD increases with the Richardson and Rossby numbers; however, it decreases with the Froude number. Even when the mountain is isotropic, an associated transverse force is generated if the sheared flow passes over the mountain on the ‐plane. By calculating OGWD analytically from more complex terrain and airflow, this study can contribute to the development of an advanced OGWD parameterization in the numerical models used for climate and weather prediction.
Biomechanical analysis of real‐time vibration exposure during mini combine harvester operation: A hybrid ANN–GA approach
Authors: Singh Gajendra , Tewari V. K. , Ambuj  , Choudhary Vinod 
Published: March 2024

AbstractThis research focuses on designing and evaluating ergonomic self‐propelled machinery seats to reduce whole‐body vibration (WBV) exposure among male and female agricultural workers. Subjects without musculoskeletal disorders were selected, and their anthropometric parameters were analyzed. An ergonomically refined seat, considering anthropometric dimensions and vibration reduction, was developed and tested. Vibration isolators using piezoelectric material enhanced operator comfort. In a laboratory experiment, real‐time one‐third octave band WBV data were collected using various seat types and engine speeds. At 1200 rpm, female operators experienced WBV levels between 3.42 and 13.40 m/s², while males ranged from 3.13 to 12.20 m/s². At 1600 rpm, females (T‐1) had WBV levels of 20.20–42.39 m/s², and males recorded 18.90–40.12 m/s². At 2000 rpm (T‐1), female operators WBV ranged from 246.71 to 303.45 m/s², and males from 248.10 to 300.13 m/s². At 2400 rpm (T‐1), female operators experienced WBV from 385.29 to 457.87 m/s², and males from 381.57 to 445.50 m/s². An integrated approach with artificial neural networks and genetic algorithms optimized machine operating parameters, resulting in minimum WBV levels. The highly accurate Multilayer Feed‐Forward Artificial Neural Network model (2‐10‐1) had a correlation (R) of 0.996 and a low mean‐squared error of 0.198. This research underscores the effectiveness of seat isolators in reducing vibrations and highlights the importance of considering both seat design and engine speed, especially concerning gender‐specific differences in vibration tolerance. It provides valuable insights for improving the comfort and safety of self‐propelled machinery operators in agriculture.
In Situ Construction of Inorganics‐Rich Cathode‐Electrolyte Interface toward Long‐Life Prussian White Cathode
Authors: Jian Xinxia , Liu Xiaowei , Yang Chao , Xie Jingjing , Hu Wenxi , Zhang Youcai , Yan Hua , Han Jin , You Ya 
Published: March 2024

AbstractPrussian white (PW) is one of the most promising candidates as a cathode for sodium‐ion batteries (SIBs) because of its high theoretical capacity, excellent rate performance, and low production cost. However, PW materials suffer severe capacity decay during long‐term cycling. In this work, a robust cathode electrolyte interface (CEI) is designed on the PW cathode by employing cresyl diphenyl phosphate (CDP) and adiponitrile (ADN) as electrolyte additives. CDP and ADN possess higher highest occupied molecular orbital energy levels (HOMO) than other solvents, leading to the preferential decomposition of CDP and ADN to construct an inorganics‐rich CEI layer in situ on the PW cathode. Benefiting from this CEI layer, the degradation of PW is effectively inhibited during the long cycling. The Na||PW cell achieves an excellent cycling performance with a capacity retention of 85.62% after 1400 cycles. This work presented here provides a feasible strategy for improving the cycling performance of PW by electrolyte modification.
Band Structure Engineering Promotes Anionic Redox Reversibility of Cobalt‐Free Li‐Rich Layered Oxides Cathodes
Authors: Gao Xianggang , Guo Juanlang , Li Shihao , Zhang Haiyan , Zhang Yi , Guan Chaohong , Wang Mengran , Lai Yanqing , Zhang Zhian 
Published: March 2024

AbstractLi‐rich layered oxides cathodes (LLOs) have prevailed as the promising high‐energy‐density cathode materials due to their distinctive anionic redox chemistry. However, uncontrollable anionic redox process usually leads to structural deterioration and electrochemical degradation. Herein, a Mo/Cl co‐doping strategy is proposed to regulate the relative position of energy band for modulating the anionic redox chemistry and strengthening the structural stability of Co‐free Li1.16Mn0.56Ni0.28O2 cathodes. The incorporation of Mo with high d state orbit and Cl with low electronegativity can narrow the band energy gap between bonding and antibonding bands via increasing the filled lower‐Hubbard band (LHB) and decreasing the non‐bonding O 2p energy bands, promoting the anionic redox reversibility. In addition, strong covalent Mo─O and Mn─Cl bonding further increases the covalency of Mn─O band to further stabilize the O2n− species and enhance the reversible distortion of MnO6 octahedron. The strengthening electronic conductivity, together with the epitaxial structure Li2MoO4 facilitates the fast Li+ kinetics. As a result, the dual doping material exhibits enhanced anionic redox reversibility and suppressed oxygen release with increased cyclic stability and excellent rate performance. This strategy provides some guidance to design high‐energy‐density LLOs with desirable anionic redox reversibility and stable crystal structure via band structure engineering.
Supporting Students' Knowledge Activation before, during, and after Reading
Authors: Hattan Courtney 
Published: March 2024

AbstractKnowledge activation and knowledge building are essential for reading comprehension. Yet, how can teachers support students in accessing and applying their existing knowledge and experiences during reading? This article provides six evidence‐based principles to consider during literacy instruction, which are drawn from a recent systematic literature review that examined prior knowledge activation instructional scaffolds. These principles are: (a) activate knowledge before, during, and after reading; (b) activate knowledge collaboratively; (c) support students in understanding connections between concepts; (d) support students in recognizing discrepancies between their knowledge and the text; (e) address misunderstandings; and (f) consider the amount of topic‐specific knowledge that students have. These principles have the potential to shift how teachers think about the role of knowledge activation throughout the reading process.
Evaluation of radiological and anatomical features of skull bones in adult Saanen goat
Authors: Alizadeh Siamak , Kamfar Pourya , Hosseinchi Mohammadreza 
Published: March 2024

AbstractBackgroundObtaining accurate knowledge of the anatomical structure of the skull helps in ontogenetic studies and determining sexual polymorphisms.ObjectivesThis study uses anatomical dissection and radiography to develop a size standard for the skull of the Saanen goat; information that will be applied to clinical evaluation and decision‐making.MethodsA total of 14 adult Saanen goat skulls (7 male and 7 female goats) were taken from the slaughterhouse and transferred to the clinic of the Faculty of Veterinary Medical Teaching Hospital, Urmia University, Urmia, Iran. Radiographs of each skull were prepared in the dorsal–ventral, left and right lateral recumbency. These heads were then brought over to the anatomy department, where the chosen morphometric traits were assessed and their means recorded.ResultsAccording to the findings of this study, the dorsal view of the skull revealed an incisive raphe and a widespread foramen of the nose. In the ventral view, the incisive bones were observed in the most cranial region of the skull. The base of the occipital bone was relatively large, and the jugular process was well‐developed. In the lateral view, the incisive bone was extended to the cranial and had a narrow process on the dorsal surface. Regarding infra‐orbital foramen, it was visible in the maxillary bone. Moreover, the lacrimal bone was perceived as a distinct bone.ConclusionThe precise standards acquired in this study can be utilized to interpret the findings and make clinical decisions about the normal and abnormal size of the bones that make up the skulls of the Saanen goats.
YAP/TAZ-TEAD activity promotes the malignant transformation of cervical intraepithelial neoplasia through enhancing the characteristics and Warburg effect of cancer stem cells
Authors: Li Shu , Li Xing , Yang Yong-bin , Wu Su-fang 
Published: March 2024

AbstractA number of studies have confirmed that Yes-associated protein (YAP)/transcriptional co-activator with PDZ-binding motif (TAZ)-transcriptional enhanced associate domain (TEAD) activity is the driver of cancer development. However, the role and mechanism of the YAP/TAZ-TEAD pathway in cervical intraepithelial neoplasia (CIN) remain to be clarified. Therefore, this study was designed to observe the effect of YAP/TAZ-TEAD activity on the development of CIN and provide new ideas for the diagnosis and treatment of CIN. Firstly, cervical tissues were collected from CIN patients in different stages [CIN grade 1 (CIN1) tissue, CIN grade 2/3 (CIN 2/3) and squamous cell carcinoma (SCC)] and healthy volunteers. Next, the expression levels of YAP, TAZ and TEAD in cervical tissues and cells were observed by immunohistochemistry, qRT-PCR and western blot. Besides, Z172 and Z183 cells were transfected with siRNA-YAP/TAZ (si-YAP/TAZ) and YAP/TAZ overexpression vector (YAP-5SA). Also, Z172 cells were co-transfected with YAP-5SA and si-TEAD2/4. Subsequently, the stemness characteristics, glycolysis level and malignant transformation of cells in each group were observed by sphere-formation assay, commercial kit, MTT, Transwell, scratch experiment, xenotransplantation and western blot.The expression of YAP, TAZ and TEAD increased significantly in cervical cancer tissue and cell line at the stage of CIN2/3 and SCC. When YAP/TAZ was knocked down, the stemness characteristics, glycolysis level and malignant transformation of cancer cells were notably inhibited; while activating YAP/TAZ exhibited a completely opposite result. In addition, activating YAP/TAZ and knocking down the TEAD expression at the same time significant weakened the effect of activated YAP/TAZ signal on precancerous cells and reduced inhibitory effect of knocking down TEAD alone. YAP/TAZ-TEAD signal activates the characteristics and Warburg effect of cancer stem cells, thereby promoting the malignant transformation of CIN.
Seismic behaviour of Exterior RC beam-column joints repaired and strengthened using post-tensioned metal straps
Authors: Helal Yasser , Garcia Reyes , Imjai Thanongsak , Aosai Pakjira , Guadagnini Maurizio , Pilakoutas Kypros 
Published: March 2024

AbstractExterior beam-column joints are the most vulnerable part of substandard reinforced concrete (RC) buildings and are often the first to be damaged during earthquakes. This article presents an experimental and numerical investigation into the behaviour of exterior RC beam-column joints repaired and strengthened using Post-Tensioned Metal Straps (PTMS) for active confinement. The study focused on full-scale beam-column joints with an inadequate core zone detailing, thus emulating the deficiencies found in existing substandard RC buildings. Initially, four “bare” joints were subjected to cyclic tests to induce substantial damage within the core zone. Subsequently, the damaged core of the joints was repaired and recast with new concrete, and PTMS were applied to strengthen the joints, followed by another round of cyclic testing. The experimental findings were compared with predictions generated through established models from existing literature. The results revealed that ASCE/SEI 41–17 guidelines accurately predict the shear capacity of the bare joints. It is shown that recasting the core with new concrete significantly increased the joint’s shear capacity by up to 42% compared their bare counterparts. The use of PTMS strengthening further enhanced the capacity by up to 25%. A “scissors model” was employed for numerical simulations of both bare and PTMS-strengthened joints using DRAIN-2DX, which proved effective at predicting their nonlinear load-displacement envelope response. This article contributes towards the development of new cost-effective post-earthquake strengthening techniques for beam-column joints, with the potential to reduce the vulnerability of substandard RC buildings in developing countries.
Longitudinal modeling of efficacy response in patients with lupus nephritis receiving belimumab
Authors: Simeoni Monica , Yang Shuying , Tompson Debra J. , Dimelow Richard 
Published: March 2024

AbstractBelimumab was approved for active lupus nephritis (LN) in adults in the European Union and patients ≥ 5 years of age in the USA based on a Phase 3, double-blind, placebo-controlled, 104-week study. The study evaluated the efficacy of belimumab plus background standard therapy in adults with active LN using an intravenous (IV) dose of 10 mg/kg. A longitudinal analysis of Primary Efficacy Renal Response (PERR) and Complete Renal Response (CRR) was performed to assess whether patients with high proteinuria at the start of belimumab treatment would benefit from a higher dose. Responder probability was modeled as a logistic regression with probability a function of time and treatment (belimumab or placebo). Dropout risk at each visit was incorporated into a joint model of efficacy response; only efficacy data prior to dropout events (belimumab discontinuation, treatment failure, or withdrawal) were included. Average belimumab concentration over the first 4 and 12 weeks and baseline proteinuria were considered as continuous covariates. In general, renal response (PERR and CRR) over time was higher in patients receiving belimumab than in those receiving placebo. Baseline proteinuria was considered the most relevant predictor of renal response, with reduced efficacy in patients with increased proteinuria for both belimumab or placebo treatment. For belimumab-treated patients, belimumab exposure was not found to be an important predictor of renal response. In conclusion, the 10 mg/kg IV dose was considered appropriate in all patients and there was no evidence to suggest a higher response would be achieved by increasing the dose.
Training data influence analysis and estimation: a survey
Authors: Hammoudeh Zayd , Lowd Daniel 
Published: March 2024

AbstractGood models require good training data. For overparameterized deep models, the causal relationship between training data and model predictions is increasingly opaque and poorly understood. Influence analysis partially demystifies training’s underlying interactions by quantifying the amount each training instance alters the final model. Measuring the training data’s influence exactly can be provably hard in the worst case; this has led to the development and use of influence estimators, which only approximate the true influence. This paper provides the first comprehensive survey of training data influence analysis and estimation. We begin by formalizing the various, and in places orthogonal, definitions of training data influence. We then organize state-of-the-art influence analysis methods into a taxonomy; we describe each of these methods in detail and compare their underlying assumptions, asymptotic complexities, and overall strengths and weaknesses. Finally, we propose future research directions to make influence analysis more useful in practice as well as more theoretically and empirically sound.
Multiple solitons structures in optical fibers via PNLSE with a novel truncated M-derivative: modulated wave gain
Authors: Abdel-Gawad H. I. 
Published: March 2024

AbstractThis study introduces a novel truncated Mittage–Leffler (M)- proportional derivative (TMPD) and examines its impact on the perturbed nonlinear Schrödinger equation (PNLSE) that includes fourth-order dispersion and cubic-quintic nonlinearity. The TMPD-PNLSE is used to model light signals in nanofibers. In addition to dispersion and Kerr nonlinearity, which are characteristics of the NLSE, the PNLSE also exhibits self-steepening and self-phase modulation effects. The unified method is implemented to derive exact solutions for the model equation. These solutions provide a variety of phenomena; including breathers, geometric chaos, and complex solitons. The solutions also exhibit numerous structures, such as geometric chaos, where undulated M-shaped and M-shaped solitons are embedded. The modulation instability is analyzed, finding that it is triggered when the coefficient of the fourth-order dispersion surpasses a critical value.
THz radiation distribution for the identification of infiltrating ductal carcinoma in human breast model: a computational study
Authors: Mahdy Shimaa , Hamdy Omnia 
Published: March 2024

AbstractWith numerous biomedical applications of terahertz (THz) imaging, spectroscopy, and sensing, the THz regime of the spectrum is quickly emerging as an important area of research with the potential to usher in a new era in the healthcare industry. In the medical field, THz radiation has been explored to diagnose and monitor several ailments, including foot diabetes, skin dryness, wounds, and burns. Compared to X-rays, THz waves' phase sensitivity to bodily fluid levels and water results in superior contrast and stronger absorption. This feature makes THz potentially useful for the diagnosis of various malignant tumor forms because cancerous tumors have higher water molecule contents than healthy tissues. The current study presents a computational analysis of a CW-THz point-by-point scanning technique for breast cancer detection. COMSOL multiphysics platform was utilized to create a multilayer three-dimensional breast model containing an irregular-shaped infiltrating ductal carcinoma in the glandular layer. The propagation of the THz radiation in the constructed breast model was simulated based on the radio frequency module and electromagnetic waves in the frequency domain interface. Furthermore, different volumes and locations of the induced tumor were examined. The results demonstrated significant disparities in the acquired electric distribution at different tumor sizes and sites between normal and diseased breasts. The resultant electric field for healthy breast ranged from 1.1 × 10–5 to 0.61 V/m, however, the electric field ranges following tumor addition fluctuate based on its volume and location. Additionally, the position of the THz source and detector array influences the reflected THz signal.
Estimation of health utility values for alopecia areata
Authors: Aggio Daniel , Dixon Caleb , Law Ernest H. , Randall Rowena , Price Thomas , Lloyd Andrew 
Published: March 2024

Abstract
Purpose
Alopecia areata (AA) is an autoimmune-mediated inflammatory dermatological disease characterised by non-scarring hair loss affecting the scalp and sometimes other hair-bearing sites. This study aimed to elicit health state utility values (HSUVs) from the UK general population for AA using time trade off (TTO) interviews.

Methods
Vignette descriptions of health states defined by the extent of hair loss were developed (as well as one describing caregiver burden). These were developed using data from standardised patient reported outcome (PRO) measures, a literature review and qualitative interviews. Health states were defined based on the severity of alopecia tool (SALT), which assesses extensiveness of scalp hair loss. HSUVs were then elicited for each health state in TTO interviews with the UK public.

Results
One caregiver and five patient health states were developed based on the literature review findings, clinical trial PRO (Hospital Anxiety and Depression Scale and Alopecia Areata Patient Priority Outcomes Questionnaire) data and qualitative interviews with patients (N = 11), clinical experts (N = 4) and caregivers of adolescents with AA (N = 10). These data showed a more severe impact among patients with more extensive hair loss. One hundred and twenty participants evaluated the vignettes in TTO interviews. Patient HSUVs ranged from 0.502 for the most extensive hair loss health state (SALT 50–100 + eyebrow and eyelash loss) to 0.919 (SALT 0–10) for the mildest health state. The caregiver HSUV was 0.882.

Conclusion
Quantitative and qualitative data sources were used to develop and validate vignettes describing different AA health states. Patient and caregiver HSUVs demonstrate a large impact associated with AA, especially for states defined by more extensive hair loss.