bluuebunny/crossref_metadata_2025_split huggingface dataset:
Disulfiram, an Anti-alcoholic Drug, Targets Macrophages and Attenuates Acute Rejection in Rat Lung Allografts
Authors: Yoshiyasu Nobuyuki , Matsuki Rei , Sato Masaaki , Urushiyama Hirokazu , Toda Etsuko , Terasaki Yasuhiro , Suzuki Masaki , Shinozaki-Ushiku Aya , Terashima Yuya , Nakajima Jun 
Published: April 2024

Macrophages contribute to post-transplant lung rejection. Disulfiram (DSF), an anti-alcoholic drug, has an anti-inflammatory effect and regulates macrophage chemotactic activity. Here, we investigated DSF efficacy in suppressing acute rejection post-lung transplantation. Male Lewis rats (280–300 g) received orthotopic left lung transplants from Fisher 344 rats (minor histocompatibility antigen-mismatched transplantation). DSF (0.75 mg/h) monotherapy or co-solvent only (50% hydroxypropyl-β-cyclodextrin) as control was subcutaneously administered for 7 days (n = 10/group). No post-transplant immunosuppressant was administered. Grades of acute rejection, infiltration of immune cells positive for CD68, CD3, or CD79a, and gene expression of monocyte chemoattractant protein and pro-inflammatory cytokines in the grafts were assessed 7 days post-transplantation. The DSF-treated group had significantly milder lymphocytic bronchiolitis than the control group. The infiltration levels of CD68+ or CD3+ cells to the peribronchial area were significantly lower in the DSF than in the control groups. The normalized expression of chemokine ligand 2 and interleukin-6 mRNA in allografts was lower in the DSF than in the control groups. Validation assay revealed interleukin-6 expression to be significantly lower in the DSF than in the control groups. DSF can alleviate acute rejection post-lung transplantation by reducing macrophage accumulation around peripheral bronchi and suppressing pro-inflammatory cytokine expression.
Impact of Fusarium Species Composition and Incidence on Onion Basal Rot in Northeastern Israel
Authors: Degani Ofir , Dimant Elhanan , Margalit Eliyahu 
Published: April 2024

Fusarium basal rot (FBR) places a significant limitation on Allium production worldwide. The damage caused by the disease can be observed throughout the entire crop cycle. This research aimed to further our understanding of the impact of FBR on the cultivation of onions (Allium cepa) in northeast Israel. It focused on studying the composition and incidence of Fusarium species involved in disease outbursts in two representative fields, one in Galilee (Hula Valley) and the second in the Golan Heights, where the disease incidences reached 8%. Using colony morphology, microscopic taxonomic keys, and molecular methods, a new, unreported Neocosmospora (previously Fusarium solani) species complex (SC, mostly N. falciformis) was discovered as a wildly spread member of the Fusarium pathobiome community. This species complex appeared more generalist in its nature since it was found in all three onion cultivars’ samples. It was also less virulent in seed germination (42–52% higher sprout biomass, p < 0.05) and bulb pathogenicity tests (41–45% less necrotic) than Fusarium acutatum. Whereas the Galilee yellow Orlando (Riverside) onion cultivar bulbs sampled were colonized by Neocosmospora SC (70%) and two other, less abundant species, F. oxysporum f. sp. cepae and F. acutatum (15% each), the Golan Heights field’s Fusarium community showed host specificity. In the Golan Heights field, F. oxysporum f. sp. cepae inhabited the red Ha2 onion cultivar bulbs, whereas F. acutatum colonized the yellow Ha1 cultivar (40% and 50% prevalence along with Neocosmospora SC). A better understanding of the complexity of this disease caused by different Fusarium species and with a divergence in host susceptibility and virulence is critical for developing disease management strategies. Since each Fusarium species reacts differently to pest control treatments, changes in the species composition may require specifically adapted management solutions.
Comprehensive assessment of dental implant procedures: a comparative study on different antibiotic prophylaxis regimens
Authors: Gabidullina V. R. , Tsitsiashvili A. M. , Volkov A. V. , Stankova N. V. , Zaborovsky A. V. , Tsarev V. N. , Panin A. M. , Podporina V. V. 
Published: April 2024

Relevance. The administration of antibiotics in implantology is indicated to prevent suppurative inflammation conditions. Two regimens are commonly used: a single preoperative dose or prolonged postoperative antibiotic administration. Due to ethical constraints, certain parameters of antibiotic efficacy cannot be directly evaluated within clinical trials. These include the status of the implant-mandibular segment microbiome and the histological parameters of the tissue's inflammatory response at the implant site.Materials and methods. This study employed a miniature pig model comprising 10 males. The cohort was equally divided into two groups of five animals each. Group 1 received a single preoperative dose of amoxicillin/clavulanic acid 2 ml per 20 kg body weight. Group 2 received the same initial dose prior to implantation, followed by a daily postoperative dose of amoxicillin/clavulanic acid at 1 ml per 20 kg body weight for five days. Each animal received six dental implants. An implant site microbiological test was performed pre-surgery, on Day 1, 3, 7 and 14 post-surgery. Core needle biopsies for histological examination of the tissues were performed on the same postoperative days.Results. Microbiological testing revealed that Group 2 exhibited lower levels of Streptococcus spp. on Day 3 (p = 0.04) and Porphyromonas spp. on Day 7 (p = 0.04). Group 1 demonstrated reduced levels of Fusobacterium spp. on Day 1 (p = 0.02) and Porphyromonas spp. both pre-surgery (p = 0.04) and on Day 1 (p = 0.012). Comparative analysis of histological assays from the implant sites indicated identical tissue inflammatory responses, regardless of the antibiotic prophylaxis regimen.Conclusion. Both the single-dose and the prolonged antibiotic prophylaxis regimens, using amoxicillin/clavulanic acid for dental implantation, demonstrated similar histological patterns of tissue inflammation at the implant site, along with comparable microbiota profiles within the implant site. The oral mucosa exhibited an increased population of Staphylococcus spp. and Streptococcus spp., which might contribute to the development of resistant strains, as well as Candida spp., potentially increasing the risk of candidiasis infection onset.
KEANEKARAGAMAN JENIS RUSA Cervus sp. dan Axis sp. DI BUKIT WARUWANGI, KABUPATEN SERANG, BANTEN
Authors: Cahyani Adira , Utari Mulya , Ranisah Ranisah , Amalia Reza 
Published: April 2024

Rusa merupakan hewan mamalia yang terdiri dari beberapa spesies. Spesies rusa yang ada di Indonesia misalnya rusa timor (Cervus timorensis), dan rusa totol (Axis axis). Setiap jenis rusa memiliki karakteristik atau ciri masing-masing. Penelitian ini bertujuan untuk mengetahui jenis rusa yang ada di Wisata Agro Bukit Waruwangi Kabupaten Serang. Sampel yang digunakan adalah 11 ekor rusa Timor dan 3 ekor rusa totol yang dipelihara pada dua penangkaran di bukit Waruwangi, Kabupaten serang. Metode yang digunakan adalah metode observasi yaitu denganÂ mengamati warna rambut, bentuk tanduk, pakan, lingkungan penangkaran. Hasil penelitian menunjukkan adanya perbedaan antara rusa timor dan rusa totol. Secara morfologi rusa timor memiliki warna rambut kuning kecoklatan, sedangkan pada rusa timor memiliki warna coklat terang dengan corak putih ditubuhya. Selain itu, bentuk tanduk rusa totol keras, dan runcing dibagian ujung tanduknya atau disebut tanduk keras, dan pada rusa timor terdapat dua jenis tanduk rusa yaitu tanduk keras dan pedicle. Jenis pakan rusa totol dan rusa timor yaitu ranting muda dan dedaunan. Sistem pemeliharaan rusa timor dan rusa totol pada dua kawasan penangkaran di bukit Waruwangi Kabupaten Serang, merupakan penangkaran yang semi terkurung (mini ranch) di padang savana atau padang rumput yang terjaga sanitasinya.
Role of Formoterol on Myogenic Regulatory Factor to Ameliorate Statin-induced Myopathy
Authors: Qamar Abdullah , Mughal Arsalan Manzoor , Ali Humaira , Faisal Tayyaba , Iram Maria , Malik Sana 
Published: April 2024

Objective: To investigate the effects of β2-adrenergic agonist formoterol on expression of myogenic regulatory factor myogenin in statin-induced myopathies in rats
Methods: Adult male Sprague-Dawley rats were randomized into control (A), statin-only (B), and statin + formoterol groups (C) (n=30 per group). The control group A received no treatment. B group received simvastatin at 60 mg/kg/day by oral gavage for 12 weeks to induce myotoxicity. C group received simvastatin at 60 mg/kg/day plus formoterol at 3 μg/kg/day by oral gavage for 12 weeks. After 12 weeks, extensor digitorum longus muscles were dissected and 5 μm transverse sections were immunostained for myogenin expression. One cross section was selected from each of the specimen for study. Myogenin-positive nuclei were quantified in 8 random 40x magnification fields per muscle section by a blinded investigator. Data was analyzed using IBM SPSS.
Results: Myogenin-positive nuclei were minimal in the control (A) group and statin-only (B) groups. In contrast, the statin + formoterol (C) group exhibited a significant increase in myogenin-positive nuclei compared to both control and statin-only groups (p<0.001), indicating enhanced muscle regeneration.
Conclusion: Formoterol treatment augmented skeletal muscle repair pathways in a rat model of statin-induced myopathy, potentially via activation of quiescent muscle satellite cells and upregulation of myogenic regulatory factor myogenin in group C.
A Cross-Sectional Study on the Use of Computed Tomography Scan for Diagnosing Renal Masses in Pakistani Adults
Authors: Malik Naushaba , Shahbakht Aftab  , Rida Noor  
Published: April 2024

Objective: The aim of this study is to assess the validity of Computed Tomography (CT) in evaluating solid renal masses by comparing CT findings with histopathological results.
Methodology: This cross-sectional study involved 210 patients at the Department of Radiology PESSI Hospital Islamabad, spanning July 2022 to June 2023. Patients were selected based on predefined inclusion criteria, and their detailed medical histories were examined. Each patient underwent both non-contrast and contrast CT scans, and the radiological diagnoses were confirmed. The CT-based diagnoses were then compared with histopathological results, and measures such as positive predictive value (PPV), accuracy, sensitivity, specificity, and negative predictive value (NPV) of CT in diagnosing renal masses were calculated.
Results: The mean age of the study participants was 48.00±810 years. Male to female ratio was 2:1. The majority of the study participants were belonging from the urban area and were under graduate. The results of the study further revealed the frequency of renal masses which was more in male (71.90%, n=151) as compared to female (28.09%, n=59). The study found that the right kidney was affected in 58.09% (n=122) of cases, the left kidney in 36.19% (n=76), and both kidneys in 5.71% (n=12). In our study, we observed variations in density among patients, with 39.06% exhibiting mixed density, followed by 23.80% with hypo-dense, 20.95% with hyper-dense, and 16.19% with iso-dense lesions. When it comes to enhancement, we found that 40.01% had a moderate degree, 24.76% had mild enhancement, 21.90% had intense enhancement, and 13.33% showed no enhancement.
Conclusion: In this study, we found a strong correlation between histopathological diagnosis and computed tomography (CT) in identifying solid renal masses, with notably high validity test results. Given these robust validity parameters, we can confidently conclude that CT scans serve as an effective and reliable diagnostic modality for identifying and diagnosing renal masses.
Clinical Application of Reticulocyte Maturity Indices in Early Diagnosis of Iron Deficiency Anemia in the First Trimester of Pregnancy
Authors: Imtiaz Amna , Noreen Noshina , Asghar Rabiah , Nazir Rabia , Irfan Rabeea , Anam Ali Bushra 
Published: April 2024

Background: Iron deficiency anemia (IDA) is a prevalent global health issue, particularly affecting pregnant females due to increased iron demands during pregnancy. In Pakistan, IDA remains a significant concern, posing challenges to maternal and child health. Early detection and management of iron deficiency are crucial for improving pregnancy outcomes.
Objective: This study aims to investigate the iron status and associated hematological parameters among pregnant females during the first trimester in Islamabad, Pakistan.
Methodology : This cross-sectional study, conducted in collaboration with the Pakistan Atomic Energy Commission (PAEC) and the Pakistan Institute of Medical Sciences (PIMS), aimed to investigate the iron status among first-trimester pregnant females in Islamabad, Pakistan.Laboratory investigations encompassed hemoglobin and serum ferritin assays, reticulocyte counts, and other red blood cell parameters. Participants were categorized into distinct iron status groups based on these evaluations. Utilizing SPSS version 25, statistical analysis followed ethical protocols, striving to uncover discrepancies in hematological parameters across the various iron status groups.
Results : Among 340 first-trimester pregnant women, three iron status groups were identified. Group 1 (n = 102) had low ferritin despite normal Hb, with elevated immature reticulocytes. Group 2 (n = 150) showed normal iron parameters, while Group 3 (n = 88) had high reticulocyte counts. Group 2 exhibited superior erythrocyte indices and higher ferritin levels than Groups 1 and 3. Group 3 displayed the poorest indices and elevated immature reticulocytes. These findings highlight variations in iron status and reticulocyte maturation among pregnant women.
Conclusion: This study underscores the high prevalence of iron deficiency anemia among first-trimester pregnant females in Islamabad, Pakistan. Variations in red blood cell parameters and serum ferritin levels highlight the importance of early iron status assessment for optimizing maternal and foetal health outcomes.
High-temperature growth of ZnSnN2 layer via radiofrequency magnetron sputter epitaxy
Authors: Shinoda Hiroyuki , Mutsukura Nobuki 
Published: April 2024

Abstract
ZnSnN2 layers were grown directly on Al2O3 (0001) substrates via RF magnetron sputter epitaxy at various substrate temperatures using N2 gas and a ZnSn alloy target. The crystalline quality and surface morphology of the ZnSnN2 layers were examined. X-ray diffraction patterns indicated that ZnSnN2 layers grown at substrate temperatures of 600 °C and 700 °C had wurtzite-type structures. The gross full width at half maximum (FWHM) value of the X-ray rocking curve (XRC) for the (0002) plane of the ZnSnN2 layer grown at 700 °C was 324 arcsec. The XRC for the (0002) plane contained two components, and the FWHM values of these components were 206 and 1520 arcsec for the highly c-axis-oriented columnar domains and disordered structure inside the ZnSnN2 layer, respectively. Metallic Sn was detected in a ZnSnN2 layer grown at 800 °C.
PRODUÇÕES BRASILEIRAS SOBRE FORMAÇÃO INICIAL DE PROFESSORES A PARTIR DO PIBID E RESIDÊNCIA PEDAGÓGICA
Authors: Cunha dos Santos Carlos Antonio , Rodrigues Feio Leila do Socorro , Wielewski Gladys Denise , Marques Vasconcelos de Almeida Laura Isabel , Parentes da Silva do Amaral Ferreira Francisco de Assis , Martins da Silva Vilmar 
Published: April 2024

Formação de professores suscita intensos debates e tem resultado em extensa produção científica na área educacional. Mesmo assim, o déficit de professores em todas as etapas da educação básica pode chegar a 235 mil em 2040. O objetivo do estudo de caráter descritivo e analítico foi, a partir do estado do conhecimento, investigar o panorama das pesquisas sobre o Programa Institucional de Bolsa de Iniciação à Docência (PIBID) e o Programa de Residência Pedagógica (PRP) na formação de professores utilizando como embasamento teórico os estudos de Gatti et al. (2019), Nóvoa (2017) e Tardif (2014). O levantamento foi realizado através de consulta ao Catálogo de Teses e Dissertações da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Capes) sob o recorte temporal de 2020 a 2023. O resultado revelou que as produções estão concentradas nos Programas de Pós-Graduações(PPG) dos estados do Sudeste e Nordeste do país e que são abordadas, com maior frequência, temáticas sobre: o estímulo à formação de professores reflexivos, construção da identidade profissional docente, inovação pedagógica e as contribuições para a formação inicial de professores.
feminismo negro surdo na educação inclusiva
Authors: Oliveira Júnior Ailton Paulo de , Oliveira Santos Eliana Rosa de 
Published: April 2024

O presente artigo teve como objetivo investigar como o tema gênero, o feminismo negro, tem sido tratado nas pesquisas voltadas à Educação de surdos no Brasil. Realizou-se, para tanto, uma revisão sistemática de literatura, considerando a Biblioteca Digital Brasileira de Teses e Dissertações (BDTD), o Catálogo de Teses e Dissertações da Capes e o Google Acadêmico, de textos publicados entre 2016 e 2022, tendo por descritores de busca: “feminismo”, “negro”, “surdo”, “raça” e “gênero”. Identificamos que as pesquisas na área da surdez tendem a considerar apenas os aspectos linguísticos do surdo, mesmo quando se discute a sua identidade. Temas como etnia/raça, gênero, sexualidade e classe social são deixados em segundo plano ou sequer são mencionados. A população surda ainda está caminhando no sentido de ser reconhecida e de ter sua língua respeitada; provavelmente por isso, essas temáticas no âmbito das pesquisas educacionais tenham se revelado ainda pouco discutidas. É preciso considerar, que a comunidade surda não é homogênea, existem interseccionalidades que podem incidir sobre a vida das pessoas que fazem parte dessa população. Tornam-se necessários estudos da sobreposição da surdez-etnia/raça, de gênero e de sexualidade, associadas à Educação Inclusiva, para ressignificar concepções e práticas voltadas para a população surda que por muito tempo foi espoliada e cerceada de seus direitos.
Parental Involvement in Assisting the Student in the Social Domain: The Educators' Perspective
Authors: Korem Anat 
Published: April 2024

Abstract
Parental involvement is one of the key issues in education that remains a constant part of the public and academic agenda, but little is known about the perspective of educators on parental involvement in assisting the student in the social domain. It is essential to throw light on this perspective in order to construct an effective parent-educator partnership in this domain. This qualitative study focuses on educators' perspectives (perceptions and strategies). It is based on analyses of 10 case studies perceived by educators as successful and 16 statements by educators, which were not connected to a specific case study, but expressed their views about parents generally. It was found that the educators' perceptions include positive and negative aspects. Three types of effective strategies have emerged from the data: creating good communication with parents, giving practical advice to parents, and driving positive change in the relations between the child and their parents. The conclusions point to aspects that should be emphasized in teacher education, particularly professional training in how to develop social competence in students.
Tireless worker of Azerbaijani Russian studies
Authors: Мамедов Насирага 
Published: April 2024

В 2023 г. исполнилось 65 лет доктору философии, доценту кафедры практического русского языка и методики его преподавания и заведующему отделом практики и развития карьеры выпускников Бакинского славянского университета Яшару Камиловичу Алхасову, посвятившему всю жизнь изучению и пропаганде русской словесности в Азербайджане и за его пределами.
Yashar Kamilovich Alhasov, Doctor of Philosophy, Associate Professor of the Department of Practical Russian Language and Methodology of its Teaching, Head of the Department of Practice and Career Development of Graduates of Baku Slavic University, who devoted all his life to the study and popularization of Russian literature in Azerbaijan and beyond, is 65 years old in 2023.
Development of Ryazan social environment in the 1950s and 1960s as a condition for improving the quality of life
Authors: Терехин А.Н. , Попова О.Д. 
Published: April 2024

Строительство и жилищно-коммунальное хозяйство являются одним из самых важных отраслей в экономике России. Они определяют занятость, доходы десятков миллионов граждан, вносят огромный вклад в создание комфортных условий жизнедеятельности людей. Эти сферы обуславливают внутреннее экономическое развитие государства, так как под собой подразумевают многочисленные факторы, влияющие на показатели жизни граждан. Жилье входит в число базовых потребностей человека, одной из важнейших задач любого развитого государства является обеспечение граждан доступным и комфортным жильем. Влияние этой отрасли на жизнь людей огромно, она формирует социальное пространство в городах.
Construction, housing and communal services are one of the most important sectors of the Russian economy. They determine employment, incomes of tens of millions of citizens, and make a huge contribution to creating comfortable living conditions for people. These areas determine the internal economic development of the state, since they imply numerous factors affecting the life indicators of citizens. Housing is among the basic human needs: to provide citizens with affordable and comfortable housing is one of the most important tasks of any developed state. The impact of this industry on people’s lives is huge; it forms an urban social environment.
Soviet patriotism as a cultural phenomenon
Authors: Сулимов С.И. , Черниговских И.В. 
Published: April 2024

В фокусе внимания авторов – патриотическое мироощущение, сформированное культурной политикой СССР и событиями, происходившими в стране на протяжении ХХ века.
The authors focus on the patriotic outlook formed by the cultural policy of the USSR and the events that took place in the country during the 20th century.
“Bilingua” contest plays an important role in reviving the culture of the indigenous minorities of Russia
Authors: Бурова А.А. , Яхина Д.К. 
Published: April 2024

Авторы размышляют о молодежных этнокультурных проектах в среде коренных малочисленных народов Дальнего Востока, делятся своими знаниями о родной культуре орочей и роли ежегодного конкурса «Билингва» в сохранении языкового и культурного разнообразия страны.
The authors reflect on the Youth ethnocultural projects for the indigenous minorities of the Far East, share their knowledge of the native culture of the Orochies, and the role of the annual “Bilingua” contest in preserving the linguistic and cultural diversity of the peoples of Russia.
Posibles precedentes latinos del «bien o mal, qual puntares» (Arcipreste de Hita, Libro de buen amor 70b)
Authors: Escobar Chico Ángel 
Published: April 2024

La controversia en torno al significado de «puntar» en una célebre estrofa del Libro de buen amor (70b) podría quizá dirimirse mejor atendiendo también a un pasaje del Speculum musicae de Jacobo de Lieja (I 17) en el que, sobre base isidoriana, se formulan conceptos comparables a los expresados por el Arcipreste.