bluuebunny/crossref_metadata_2025_split huggingface dataset:
(O-12) MODULATION OF MMP EXPRESSION AND COLLAGEN DEPOSITION IN THE TUNICA ALBUGINEA IN PEYRONIE´S DISEASE INDUCED AFTER TREATMENT WITH MYCOPHENOLATE MOFETIL
Authors: Facio F , Antoniassi T , Rocha Ruiz T F , Taboga S , Jacovaci Colleta S , Falleiros Junior L R 
Published: March 2024

Abstract

Peyronie's disease (PD) is a progressive fibrotic disorder affecting the tunica albuginea (TA) of the penis. MMF was evaluated previously after experimental induction of PD. We investigate the modulation of metalloprotease (MMP) expression and collagen deposition in the TA in PD induced after treatment with MMF in rats. Rats were divided into: control group; sham (injection of saline solution); only TGFβ injection (7 or 30 days); TGFβ injection and treatment with MMF (7 or 30 days). Samples were collected for histochemical and immunohistochemistry, measurements of collagen fibers and MMP expression were performed in random fields. Statistical analyses were checked for normality using the Kolmogorov-Smirnov test, followed by ANOVA test or Kruskal-Wallis test.

Results
Collagen type I (COLI) was decreased in 7 and 30 days (43.19% ± 1.22; 38.14%1.23), and collagen type III (COLIII) was increased in both periods in the TGFβ induction (56.81% ± 1.22; 61.86% ± 1.23). COLI/COLIII ratio of MMF treatment (7 days) was enhanced (54.74% ± 2.86; 45.26% ± 2.88). COLI (7 and 30 days) were statistically different, as well as 30 days of MMF treatment decreased COLIII (27.41% ± 3.11). MMP was increased at 7 days after TGFβ induction. However, 30 days after induction, MMP expression decreased (1.67% ± 0.16), whereas, with MMF treatment, increased (2.44% ± 0.22). MMP3 expression was similar in both groups. Within 7 days, MMP was enhanced (4.77% ± 0.37; 4.43% ± 0.43) and decreased in 30 days (3.73% ± 0.38; 3.20% ± 0.33). MMP presented an enhancement at 7 days in TGFβ-induction, with (17.56% ± 0.97) or without (13.41% ± 1.31) MMF treatment. However, with MMF treatment at 7 days, MMP showed increased values, and, at 30 days, MMP no differences were observed.

Conclusions
Induction with TGFβ promoted an imbalance the COLI/COLIII ratio of the tunica albuginea, and the MMF treatment promoted recovery of collagen status. MMP expression were altered, and MMF promoted the collagen recovery by MMP modulation.

Financing
No conflict.
(O-19) GENDER REASSIGNMENT IN TRANSGENDER MEN IN BOGOTá, COLOMBIA
Authors: Coronado Villarreal M J , Fehrmann Rivera S , Montenegro Gutiérrez M J , Peña Plazas L N , Ramírez Salguero L V , Sánchez Otero V 
Published: March 2024

Abstract

Introduction
In the 21st century, the transgender population begun to have greater visibility and advances within the health field in terms of gender reassignment. This transition covers four aspects which includes legal, social, surgical reassignment and hormone therapy. Although the word transgender is no longer in the disorders section, it’s still seen as a disease. For this reason, the transgender population continues to be pathologized. In Bogotá, Colombia, information on the processes that encompass gender reassignment is currently not sufficient.

Objective
To understand the perception of transgender men about the four aspects of the female-to-male gender reassignment currently taking place in Bogotá.

Method
Qualitative descriptive study with biographical/narrative design carried out using semi-structured interviews were conducted with 4 transgender men over 18 years who have completed at least one of the aspects in Bogotá. These interviews were audio recorded, transcribed and analyzed. The results were divided into 2 dimensions, which were subdivided into various categories.

Results and discussion
Once gender reassignment began, most transgender men opt to start with the social aspect because it allows them to present themselves to society in their desired way. After this, they continued with the legal, hormonal and surgical aspects according to each person's preference. As a result, a lack of protocols and poor follow-up of health care guidelines for adequate care of this population were evident.

Financing
No conflict.
(O-24) EFFICACY OF ASPIRATION AND SCLEROTHERAPY FOR HYDROCELE: A SYSTEMATIC REVIEW
Authors: Freitas F C , Sanches M R , Dosatti AdC 
Published: March 2024

Abstract

Introduction and Objetives
Hydroceles are abnormal collection of fluid between the parietal and visceral layers of the tunica vaginalis. Traditionally, surgical excision and or repair under general anaesthesia has been the standard of care, but sclerosant therapy can be used safely and with efficacy for hydrocele’s treatment. This study aims to review and elucidate the current literature sclerotherapy for hydrocele.

Methods
We searched for articles in Pubmed, Embase and Cochrane evaluating aspiration and sclerotherapy for hydrocele treatment. Search terms were “hydrocele” and “sclerotherapy”. Relevant papers references were full reviewed searching for new articles. The sclerosing agents considered eligle were phenol, tetracycline, sodium tetradecyl sulfate, phenol and alcohol.

Results
We included 1554 patients from 26 studies. Mean aspirative hydrocele volume was 238,3 mL. Cure rate was seen in 58,3% to 76% after a single procedure in STDS studies and 70% to 94,11% overall success. Phenol’s studies demonstrated a 47.5% to 70% cure rate with one sclerotherapy and 96.5% to 100% overall success. In Sclerotheraphy with tetracycline cure rate after a single procedure was 57% to 100% and overall success was 77% to 100%. Of the polidocanol group, cure rate was 42.3% to 62.1% after one sclerotherapy and overall success was 51.7% to 94%. Finally, in alcohol’s group we found 50% to 76.12% after one procedure and 80% to 97.62%.

Conclusion
A better cure rate after one procedure was observed with tetracycline and overall success after multiples procedures was seen with phenol. Due to heterogeneity and biases of the studies, more controlled clinical trials must be done to elucidate the best sclerosant agents.

Financing
No conflict.
(O-30) ONLINE GROUP THERAPY ASSOCIATED WITH PAROXETINE HYDROCHLORIDE FOR COMPULSIVE SEXUAL BEHAVIOR DISORDER´S TREATMENT: A CASE REPORT
Authors: Abensur M , Calle Roldán N M , Mutti K T , Abdo C H N 
Published: March 2024

Abstract

Compulsive Sexual Behaviour Disorder (CSBD) is characterized in ICD-11 as a persistent inability to control intense sexual urges resulting in repetitive sexual behaviours and negative effects in personal life.
Due to the limited research on CSBD´s treatment, our goal is to report a successful case of 39-year-old symptomatic male patient, treated in a structured closed online group focused on self and CSBD´s knowledge, new habits acquisition, particularities of these patients´ profile, associated with medication use.

Method
the information in this report were obtained through patient interviews, psychiatric and psychological records and literature review.
The treatment took place in an outpatient service specialized in sexuality at a public institution. Following CSBD diagnosis, Paroxetine Hydrochloride (20mg/day) was prescribed with regular psychiatric follow-ups. And was referred to an online psychotherapy group consisting of 4 CSBD participants, 2 therapists, weekly 1-hour sessions held for 10 months. The therapy addressed pertinent issues to the treatment and utilized neuropsychoeducational sessions to establish new habits, along with reflective “homework” tasks.

Results
Psychotherapeutic treatment enhanced self-knowledge leading to a loss of meaning to his compulsive behaviours, therefore, a decrease in its frequency. The patient developed a healthy sexuality, free from guilt and risky behaviours, improved emotional management and diversified interests.
Paroxetine Hydrochloride (20mg/day) facilitated the psychotherapy process (10 months), allowing gradual dosage reduction upon symptom alleviation.

Conclusion
The combination of themed online group psychotherapy, a well-established group bond, neuropsychoeducation, and medication effectively addressed CSBD symptoms, enhanced emotional management, and improved quality of life. The positive outcome encourages future research into this treatment approach for CSBD.

Financing
No conflict.
(O-32) PRIMARY DEPTH DYSPAREUNIA IS CAUSED BY THE INCOMPATIBILITY OF THE SIZE OF THE PENIS WITH THE VAGINA
Authors: Matthes AdCS 
Published: March 2024

Abstract

Introduction/Objective
Dyspareunia, to this day, is not yet fully understood. It is known that the size of the distended vagina is variable, as well as the size of the penis.
A vagina distended by a larger penis, suffers trauma and pain. The work aims to measure the flexibility of the human vagina, to guide professionals, who treat women with this complaint.

Methods
Women who signed the informed consent form and underwent vaginal surgeries under anesthesia had their vagina measured in the specular examination according to the POP-Q (total length of the vagina, measurement from the hymen to the deepest portion of the vagina) and also the same measurement with maximum distension of the vagina verified by the resistance to the introduction of a centimetric device. The difference in the measurements obtained determined the flexibility of the vagina in centimeters.

Results
A total of 120 vaginas were measured. The smallest vagina, measured without distention, was 5 centimeters and with distension of 10 centimeters. The largest, without distension, was 13.5 centimeters and with distension of 16 centimeters. Women with genital prolapse showed greater flexibility, ranging from 0.5 cm to 8 cm.

Conclusions
1-The largest measured distention of a vagina was 16 centimeters, which implies that penises larger than 16 centimeters, if penetrated completely, will cause some degree of vaginal trauma. 2-The smallest distended vagina measured 10 centimeters, so any penis that penetrates 10 centimeters into the female vagina will not cause trauma. 3-Women with complaints of pelvic pain associated with depth dyspareunia should be advised about trauma to the vaginal fundus or presence of gynecological pathology, as well as Relative Short Vagina Syndrome. 4-Professionals who serve women and couples need to understand this new concept of depth dyspareunia. However, further well-controlled studies should be conducted to consolidate this new knowledge.

Financing
No conflict.
(O-37) PORNOGRAPHY CONSUMPTION AND SEXUAL SATISFACTION IN BRAZILIAN ADULTS
Authors: Cini da Cunha M E , Fernandes Soares G , Fernanda Habigzang L 
Published: March 2024

Abstract

Introduction/Objective
It is estimated that, worldwide, 40 million adults watch pornography regularly. Understanding sexuality as a social construction and sexual satisfaction as a construct with emotional, relational, physical and cultural characteristics. The aim of this research is to understand the relationship between pornography consumption and the sexual behaviors of its consumers; and compare pornography consumption, considering the gender of consumers.

Material and Methods
Quantitative, correlational and cross-sectional study. The following instruments were used: sociodemographic questionnaire, questionnaire on pornography consumption (frequency, type, form of use, source of content, age of first access and motivation for use), questions on condom use and a rating scale. emotional sexual satisfaction. In total, 993 adults responded to the online survey.

Results
Pornography consumption patterns differed according to the gender of consumers, in relation to the age of first exposute to pornography, frequency and motivation for consumption. Men started consumption earlier and have a higher frequency of consumption compared to women. Men report use for excitement, avoidance of uncomfortable feelings, and boredom. Among women, use involves sexual activity with a partner, curiosity and learning different practices. In the network analysis, gender played a mediating role between pornography consumption and emotional sexual satisfaction. Condom use was not related to sexual satisfaction or pornography consumption. The violent pornography consumption score was a predictor of lower levels of emotional sexual satisfaction.

Conclusions
Pornography consumption, both violent and non-violent, and being male are associated with lower levels of emotional sexual satisfaction. Such results can support interventions to promote sexual health.

Financing
Bolsa PRO-Stricto Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS).
(O-39) CIRANDA- HUMAN BEHAVIOR AND SEXUALITY: EXPERIENCE OF A SEXUAL EDUCATION SERVICE IN BRAZIL
Authors: Castiglione M , Bressani V 
Published: March 2024

Abstract

Introduction
Sexuality Education is a comprehensive educational process that includes knowledge, skills and values that enable children, young people and adults to make conscious and responsible decisions about their sexual experiences and sexuality. Addresses topics such as biological sex, sexual health care, sexual orientation, gender identity and gender expression.

Objective
Describe the dynamics of an interdisciplinary service that aims to promote sexual education of people, in person and/or in a virtual environment.

Materials and Methods
Ciranda-Sexuality and Human Behavior is a sexual education service created in November 2019 by a physiotherapist and a psychologist, specialists in Human Sexuality where together they promote educational actions with a theoretical-scientific basis, in an in-person and virtual environment, such as conferences and conversation circles, live broadcasts and promotion of educational materials, posted through social networks, networks such as Instagram and other communication channels, with the aim of promoting the improvement of the exercise of sexuality by addressing various educational topics. sexual for the population.

Results
In December 2019, a conversation round was held with the presence of 20 women. With the pandemic, at the beginning of 2020, Ciranda's activities became virtual, where the presence of people from different parts of Brazil and other countries was possible. In March 2020, with the support of a marketing consultant, an Instagram page was developed where we have reached 2035 followers to date, 241 posts with educational content including videos, texts with accessible vocabulary and live streams viewed. In addition, we held talks and roundtables through the Google Meet platform for approximately 100 women. In 2022 we return to face-to-face activities

Financing
No conflict.
(PM-01) SEXUAL SATISFACTION POST PENILE PROSTHESIS IMPLANTATION
Authors: Silva-Herrera J M , Martínez-Pinedo C , Varela-Herrera D , Huertas-Cañas J M , García-Torres J S 
Published: March 2024

Abstract

Introduction
Erectile dysfunction is defined as the persistent inability to achieve or maintain an erection sufficient for a satisfactory sexual relationship. In some cases, it is refractory to pharmacological treatments, or these treatments are contraindicated, leading to the consideration of using a penile prosthesis as a definitive treatment. While reported patient and partner satisfaction rates are high (82 – 97%), dissatisfaction has been found to be attributed to various reasons, including prosthesis dysfunction and/or unmet patient expectations regarding the quality of the erection and sexual satisfaction.

Methods
An analytical observational bidirectional cohort study approved by the institutional ethics committee was conducted. Subsequently, patients who underwent penile prosthesis implantation between January 2017 and June 2021 at a single center were identified.

Results
A total of 47 cases were analyzed, with an average age of 64 years. Overall satisfaction with the penile prosthesis implantation was 100%. 94.1% felt that their treatment expectations were met, 88.2% reported continuing to use this method, and 100% were satisfied with the duration of the erection.

Conclusions
A 100% overall global satisfaction rate was observed. High rates of sexual satisfaction in patients were evident, reaffirming the penile prosthesis as a safe procedure that should be offered as a third-line treatment or when a permanent solution is desired.

Financing
No conflict.
(PM-03) EPIDEMIOLOGICAL PROFILE OF PATIENTS UNDERGOING PENILE DOPPLER ULTRASOUND AT A FEDERAL UNIVERSITY HOSPITAL IN BRAZIL
Authors: Lima V F N , Almeida GECd , Gamberini P D C , Milanez C , Lucas D C , Bechara G R , Borges C F 
Published: March 2024

Abstract

Introduction
Erectile Dysfunction (ED) refers to the inability to achieve or sustain a satisfactory erection for sexual intercourse. In Brazil, the estimated prevalence of ED among adults aged 40 to 70 years is 42.1%. For the evaluation of primary erectile dysfunction and preoperative assessment of Peyronie's disease, Penile Doppler ultrasound, involving drug-induced is recommended. This study aims to provide insights into the epidemiology of patients undergoing penile Doppler ultrasound at a Federal University Hospital.

Methods
This retrospective study gathered data from the electronic medical records of 179 patients who underwent the examination between March 2021 and March 2023, using the Phillips Affiniti 50G device. Pharmacological induction with 10 mcg/ml Alprostadil, 30 mg/ml Papaverine, and 1 mg/ml Phentolamine. Initially, 0.1 ml of this mixture was applied to the penile shaft, with subsequent adjustments made to achieve the best maximal erection.

Results
The participants ages ranged from 20 to 80 years, with an average of 59.8(±11,42) years. Marital status distribution showed 139 married and 40 were single. Ethnically, there were 57 white, 69 individuals of mixed race, and 39 black. The average Body Mass Index was 26.6(±4,13). The majority of patients identified as heterosexual (174 patients), with 51 cases of hypertension and 31 cases of diabetes. Additionally, 62 patients had radical prostatectomy. Out of the 134 patients that performed the exam with the report of erectile dysfunction, 54 were diagnosed with arterial insufficiency and 09 had venous leakage. Among the 42 exlcusive clinical report of Peyronie’s, 76% exhibited a uniplanar curvature located in the dorsal region. The average curvature angle was 47°(±19,5).

Conclusion
Erectile dysfunction was significantly more prevalent than Peyronie's disease. Among Peyronie's patients, uniplanar curvature, especially in the dorsal region, was the most common deformity type.

Financing
No conflict.
(PM-04) EFFECTS OF VIBRATORY STIMULATION AND VACUUM ERECTION DEVICE IN THE TREATMENT OF MALE SEXUAL DYSFUNCTIONS: A LITERATURE REVIEW
Authors: Marcio Cardoso E , da Costa Merino D , Fernandes Torres T , Castiglione M , Pavione Rodrigues Pereira R , Tanaka C 
Published: March 2024

Abstract

Introduction
Erectile dysfunction, premature ejaculation, retrograde ejaculation, delayed ejaculation, anejaculation, painful ejaculation, anorgasmia, hematospermia and low sexual desire are the main male sexual dysfunctions. The 2022 European Association of Urology recommends the use of vibratory stimulation and vacuum erection devices in the treatment of male sexual dysfunctions (mainly anejaculation and erectile dysfunction), both as adjuvant therapy and as combination therapy with other interventions. The objective of the study was to verify if there is scientific evidence for the use of vibrating stimulation and the vacuum erection device in male sexual dysfunctions that allow clinical indication in an effective and safe manner.

Methods
Literature review by searching for scientific articles in the Pubmed database of the National Library of Medicine published in the last 10 years, including randomized clinical trials, meta-analysis studies, pilot studies, systematic literature reviews and guidelines.

Results
As a result 1,230 articles on male sexual dysfunction. After screening, 16 studies were selected that are part of this research, seven articles on vibratory stimulation and nine on vacuum erection devices.

Conclusion
This review suggests that vacuum erection and vibratory stimulation devices, as they offer low risk, minimal side effects, are accessible and cost-effective compared to other approaches, are promising devices for the non-invasive treatment of male dysfunctions. sex. Other studies with greater methodological rigor are needed.

Descriptors
Vibratory stimulation; sexual dysfunction; penis vibrator; male sexual dysfunction; vacuum erectile; vacuum erection; Peyronie's disease

Financing
No conflict.
(PM-08) PHYSICAL ACTIVITY IN PATIENTS WITH PROSTATE CANCER: THE IMPACT ON QUALITY OF LIFE AND SEXUAL LIFE
Authors: Rodrigues E , Naccarato A , Silva I M , Sabbag D , Denardi F , Ferreira U , Matheus W E 
Published: March 2024

Abstract

Objective
Evaluate the impact of physical activity on Quality of Life and Sexual Function in patients with prostate cancer who underwent treatment – surgical or radiotherapy, or who are under active surveillance.

Material and Methods
Data is been collected through an initial interview (Identification, Anamnesis, Health Anamnesis, Degree of Satisfaction with Life and Sexuality, Affective-Emotional Assessment and Treatment Data), FACT-P, IIFE-5 short form, Physical Activity Worksheet, measurement of Heart Rate (HR) and Blood Pressure (BP) to be filled during the month. Data will be collected in 2 initial sessions, after receiving the diagnose or during treatment or active surveillance. The patients will receive physical activity guidance each week, for three months. During this period, individuals will be monitored weekly when a partial evaluation of the results obtained will be carried out.
At the end of the 12 sessions, patients will be interviewed again, using same instruments, to assess possible changes in quality of life.

Partial results
At the moment we are almost completing the 12 sessions, with 14 filled. The mean age is 65.5% years old, 90% had radical prostatectomy, 55% has minor income. The patients reported an improvement in their quality of life, in the execution of their recurrent activities, less body aches, a feeling of well being after the walk and during the day, and more disposition for the experienced activities. Confidence in achieving and maintaining an erection, changed from low to moderate.

Conclusions
It is expected to establish the relationship between the improvement of quality of life and physical activity in an educational group. After analyzing the results, it is expected to have information that will contribute to the treatment of men with prostate cancer. The results will be presented at National and/or International Congresses, and subsequently published in Scientific Journals.

Financing
No conflict.