bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Randomized trial of a cognitive‐behavioral therapy and hypnosis intervention on positive and negative affect during breast cancer radiotherapy
Authors: Schnur Julie B. , David Daniel , Kangas Maria , Green Sheryl , Bovbjerg Dana H. , Montgomery Guy H. 
Published: February 2009

AbstractBreast cancer radiotherapy can be an emotionally difficult experience. Despite this, few studies have examined the effectiveness of psychological interventions to reduce negative affect, and none to date have explicitly examined interventions to improve positive affect among breast cancer radiotherapy patients. The present study examined the effectiveness of a multimodal psychotherapeutic approach, combining cognitive‐behavioral therapy and hypnosis (CBTH), to reduce negative affect and increase positive affect in 40 women undergoing breast cancer radiotherapy. Participants were randomly assigned to receive either CBTH or standard care. Participants completed weekly self‐report measures of positive and negative affect. Repeated and univariate analyses of variance revealed that the CBTH approach reduced levels of negative affect [F(1, 38)=13.49; p=.0007, ω2=.56], and increased levels of positive affect [F(1, 38)=9.67; p=.0035, ω2=.48], during the course of radiotherapy. Additionally, relative to the control group, the CBTH group demonstrated significantly more intense positive affect [F(1, 38)=7.09; p=.0113, d=.71] and significantly less intense negative affect [F(1, 38)=10.30; p=.0027, d=.90] during radiotherapy. The CBTH group also had a significantly higher frequency of days where positive affect was greater than negative affect (85% of days assessed for the CBTH group versus 43% of the Control group) [F(1, 38)=18.16; p=.0001, d=1.16]. Therefore, the CBTH intervention has the potential to improve the affective experience of women undergoing breast cancer radiotherapy. © 2009 Wiley Periodicals, Inc. J Clin Psychol 65: 1–13, 2009.
Inulinase bio‐production using agroindustrial residues: screening of microorganisms and process parameters optimization
Authors: Makino Yemiko , Treichel Helen , Mazutti Marcio Antonio , Maugeri Francisco , Rodrigues Maria Isabel 
Published: February 2009

AbstractBACKGROUND: The use of agroindustrial residues as substrate for inulinase bio‐production is a good choice to reduce production costs, since enzyme activity will be improved and the downstream step of the process will be viable technically and economically. In addition, the screening of microorganisms that are able to overproduce inulinase using these substrates is fundamental to guarantee successful medium substitution. Based on these considerations, the objective of this present work was to select different strains of yeasts of the genus Kluyveromyces to produce the inulinase.RESULTS: Initially, 10 strains were tested in synthetic medium and six of these selected to perform tests in agroindustrial medium. Screening showed that the strains NCYC 587 and NRRL Y‐7571 were able to produce the enzyme using agroindustrial residues as substrate. Optimization of inulinase activity as a function of pH, and concentrations of molasses, corn steep liquor (CSL) and yeast extract (YE) was carried out for the two strains. The maximum inulinase activity under optimized conditions was about 750 U mL−1.CONCLUSION: These values are approximately seven times greater than the values obtained using synthetic medium, showing the technical viability of the use agroindustrial residues for the inulinase production. Copyright © 2009 Society of Chemical Industry
“Empty” sac in pregnant women with bleeding: Are measurements answering the right question?
Authors: Aziz Seerat , Cho Richard C. , Baker Diana B. , Chhor Chloe , Filly Roy A. 
Published: February 2009

AbstractPurpose.To assess the percentage of first‐trimester pregnancies with bleeding that demonstrate a visible sac but lack an identifiable embryo and have a mean sac diameter (MSD) in the controversial range of 16–20 mm.Methods.Retrospective study of all first‐trimester sonograms among women with vaginal bleeding during a 4‐year interval.Results.The study cohort consisted of 546 first‐ trimester sonograms. An embryo was not seen in 132 cases (24%). Of these, the MSD in 69 cases (52%) was <16 mm, between 16 and 19 mm in 20 cases (15%), or ≥20 mm in 39 cases (30%). The percentage of women who were threatening to abort who demonstrated a visible sac but lacked an identifiable embryo and had a MSD in the controversial range of 16–20 mm was 3.7% (20/546).Conclusion.We found that of 546 sonograms undertaken in pregnant women with vaginal bleeding in the first trimester, only 20 patients (3.7%) fell in the MSD range of 16–20 mm. Therefore, even among those diagnosticians who adopt the most stringent criterion (MSD = 20 mm), an additional examination would be requested in fewer than 1 in 25 patients. © 2009 Wiley Periodicals, Inc. J Clin Ultrasound, 2009
Chick tooth induction revisited
Authors: Cai Jinglei , Cho Sung‐Won , Ishiyama Mikio , Mikami Masato , Hosoya Akihiro , Kozawa Yukishige , Ohshima Hayato , Jung Han‐Sung 
Published: February 2009

AbstractTeeth have been missing from Aves for almost 100 million years. However, it is believed that the avian oral epithelium retains the molecular signaling required to induce odontogenesis, and this has been widely examined using heterospecific recombinations with mouse dental mesenchyme. It has also been argued that teeth can form from the avian oral epithelium owing to contamination of the mouse mesenchyme with mouse dental epithelial cells. To investigate the possibility of tooth formation from chick oral epithelium and the characteristics of possible chick enamel, we applied LacZ transgenic mice during heterospecific recombination and examined the further tooth formation. Transmission electron microscopy was used to identify the two tissues during development after heterospecific recombination. No mixing was detected between chick oral epithelium and mouse dental mesenchyme after 2 days, and secretory ameloblasts with Tomes' processes were observed after 1 week. Teeth were formed after 3 weeks with a single cusp pattern, possibly determined by epithelial factors, which is similar to that of the avian tooth in the late Jurassic period. These recombinant teeth were smaller than mouse molars, whereas perfect structures of both ameloblasts and enamel showed histological characteristics similar to those of mice. Together these observations consistent with previous report that odontogenesis is initially directed by species‐specific mesenchymal signals interplaying with common epithelial signals. J. Exp. Zool. (Mol. Dev. Evol.) 312B:465–472, 2009. © 2009 Wiley‐Liss, Inc.
The first example of a regioselective Biginelli‐like reaction based on 3‐alkylthio‐5‐amino‐1,2,4‐triazole
Authors: Chen Qiong , Jiang Li‐Li , Chen Chao‐Nan , Yang Guang‐Fu 
Published: February 2009

Abstract
magnified imageThe three‐component condensation of 3‐amino‐5‐alkylthio‐1,2,4‐triazoles with aromatic aldehydes and β‐ketoester was studied to develop a regioselective Biginelli‐like reaction. The results indicated that the reaction solvent and the properties of the β‐ketoester component displayed great influence on the regioselectivity. This is the first report about the regioselectivity of the aminotriazole‐based Biginelli‐like reaction. J. Heterocyclic Chem., (2009).
Microwave‐assisted reactions: Three component process for the synthesis of 2‐amino‐2‐chromenes under microwave heating
Authors: Mekheimer Ramadan A. , Sadek Kamal U. 
Published: February 2009

Abstract
magnified imageA simple and efficient three component process for the synthesis of 2‐amino‐2‐chromenes utilizing the reaction of aryl aldehydes 1a, 1b, 1c, 1d, 1e, 1f, 1g, 1h with active methylenes 2a,b and 1‐naphthol 3 in refluxing ethanol/piperidine under microwave‐heating is described. J. Heterocyclic Chem., (2009).
ChiWI—a road weather index for China
Authors: Nordin Lina , Gustavsson Torbjörn , Bogren Jörgen , Chen Deliang , Li Haisheng , Tian Hua 
Published: February 2009

AbstractApplication of Road Weather Information System (RWIS) for China is starting in an international perspective. However, the strong economic development during the last decades in China has caused a dramatic increase in the number of motorized vehicles, which calls for a quick development of RWIS and its application/services to safeguard the rapid development and to improve the safety of transportation. This study focuses on application of a winter index in China to quantify the need of a RWIS in different parts of China. The index is based on a concept related to various relevant weather parameters including ice, fog, snow, and wind. Its use is flexible in the sense that different types of inputs are possible, which is illustrated by a general view of the situation in China using climatological data and a case study using detailed meteorological data in Northern China. The results reveal that there are varying needs for RWIS in large parts of China. Regions with a great need for RWIS lie in the humid middle and northeastern parts of China. Some regions, however, may have a limited need for fully equipped RWIS stations. Such areas are the unpopulated areas in northwest or the dry regions in north. The results indicate that the introduced method provides useful information for China, both in the general view and in the case study. Copyright © 2009 Royal Meteorological Society
Bearing area: A new indication for suture anchor pullout strength?
Authors: Yakacki Christopher Michael , Griffis Jack , Poukalova Mariya , Gall Ken 
Published: February 2009

AbstractStudies performed to quantify the pullout strength of suture anchors have not adequately defined the basic device parameters that control monotonic pullout. The bearing area of a suture anchor can be used to understand and predict anchor pullout strength in a soft‐bone model. First, conical‐shaped test samples were varied in size and shape and tested for pullout in 5, 8, and 10 pcf sawbone models. Next, bearing area and pullout strength relationships developed from the test samples were validated against nine commercially available suture anchors, including the Mitek QuickAnchor and SpiraLok, Opus Magnum2, ArthroCare ParaSorb, and Arthrex BioCorkscrew. The samples showed a direct correlation between bearing area and pullout strength. Increased insertion depth was a secondary condition that also increased pullout strength. The pullout strength for the suture anchors followed the predicted trends of conical devices based on their individual bearing areas. For the 5 and 8 pcf models, only two and three devices, respectively, fell outside the predicted pullout strength range by more than a standard deviation. The use of a synthetic sawbone model was validated against the pullout strength of an Arthrex Corkscrew in five fresh‐frozen cadaver humeral heads. The bearing area of a suture anchor can be used to predict the pullout strength independent of design in a soft‐bone model. This work helps provide a foundation to understand the principles that affect the pullout strength of suture anchors. © 2009 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 27: 1048–1054, 2009
The survival outcome and prognostic factors for middle and distal bile duct cancer following surgical resection
Authors: Choi Sae Byeol , Park Seung Woo , Kim Kyung Sik , Choi Jin Sub , Lee Woo Jung 
Published: February 2009

AbstractBackground and ObjectivesThe objective of this study was to analyze the survival outcome and the clinicopathological factors that influence survival and recurrence of middle and distal bile duct cancer after surgical resection.MethodsFrom January 2000 to June 2007, 125 patients underwent surgical resection for middle and distal bile duct cancer. The clinicopathological characteristics and survival outcomes were reviewed retrospectively.ResultsOf the 125 patients, 31 patients underwent segmental resection of the bile duct, and 94 patients underwent pancreaticoduodenectomy (PD). Overall survival rates were 85.8% at 1 year and 38.3% at 5 years. Lymph node metastasis, noncurative resection, poorly differentiated tumor, and preoperative bilirubin level greater than 5.0 mg/dl were significant independent predictors of poor prognosis by multivariate analysis. The number of metastatic lymph nodes did not significantly affect survival. Recurrence occurred in 72 patients (61.0%). Disease‐free survival rates were 74.1% at 1 year and 42.0% at 3 years. Lymph node and distant metastases and poorly differentiated tumors were found to be significant independent predictors of recurrence by multivariate analysis.ConclusionsR0 resection confers a survival benefit, thus the surgeon should make an effort to achieve R0 resection. The presence of lymph node metastasis was a significant prognostic factor. J. Surg. Oncol. 2009;99:335–342. © 2009 Wiley‐Liss, Inc.
The relation between hypoxia‐inducible factor (HIF)‐1alpha expression with p53 expression and outcome in surgically treated supraglottic laryngeal cancer
Authors: Cabanillas R. , Rodrigo J.P. , Secades P. , Astudillo A. , Nieto C.S. , Chiara M.D. 
Published: February 2009

AbstractObjectiveThe purpose of this study was to examine whether a relationship exists between HIF‐1α expression and the pro‐apoptotic protein p53 in supraglottic laryngeal squamous cell carcinomas (SCCs), which could provide information concerning patient prognosis.MethodsThe study population was composed of 106 previously untreated men with SCC of the supraglottic larynx. All the patients underwent surgical resection of the tumor and bilateral neck dissection. Immunohistochemical analysis of HIF‐1α and p53 protein expression was performed in relation with clinicopathological parameters and prognosis.ResultsHIF‐1α nuclear expression was detected in 71% of primary carcinomas and 55% of the paired lymph node metastases. There was a significant positive correlation between HIF‐1α and T‐classification but no associations were observed with other clinicopathological variables and with prognosis. There was no correlation between the expression of HIF‐1α and p53. HIF‐1α overexpression in combination with p53 immunostaining was not associated with disease recurrence or survival.ConclusionThe data suggest that HIF‐1α expression does not have a prognostic value in surgically treated supraglottic laryngeal SCC, and that immunohistochemical determination of p53 does not allow improving the clinical significance of HIF‐1α. J. Surg. Oncol. 2009;99:373–378. © 2009 Wiley‐Liss, Inc.
The effect of preoperative transarterial chemoembolization of resectable hepatocellular carcinoma on clinical and economic outcomes
Authors: Lee King‐Teh , Lu Yi‐Wei , Wang Shen‐Nien , Chen Hong‐Yaw , Chuang Shih‐Chang , Chang Wen‐Tsan , Shi Hon‐Yi , Ker Chen‐Guo , Chiu Herng‐Chia 
Published: February 2009

AbstractBackgroundHepatocellular carcinoma (HCC) is one of the most malignant cancers in the world. The effect of preoperative transarterial chemoembolization (TACE) for resectable HCC is still controversial and cost‐associated treatments are unknown.MethodsWe retrospectively compared clinical outcomes and resource utilization after liver resection between patients who underwent preoperative TACE (TACE‐LR group, n = 114) and those who did not (LR group, n = 236).ResultsThe overall mortality rate was 27.54% for the LR group versus 39.47% for the TACE‐LR group (P < 0.05). The overall recurrent rates were 29.36% for the LR group versus 35.90% for the TACE‐LR group (P > 0.05). Multivariate Cox regression analysis showed that preoperative TACE was a significant risk factor (P = 0.002, HR = 1.995, 95% CI 1.297–3.069) for overall long‐term survival for HCC. The TACE‐LR group had longer mean lengths of stay and higher hospital charges, both at index hospitalization and at 6 months for follow‐up.ConclusionPreoperative TACE is not only associated with higher medical utilizations, but it is also correlated with higher mortality rates over a 5‐year period. The preoperative TACE does not benefit patients with resectable HCC. The golden standard or clinical guidelines should be developed to provide better clinical decisions and decision support for HCC patients. J. Surg. Oncol. 2009;99:343–350. © 2009 Wiley‐Liss, Inc.
Ultrasound‐assisted solid‐phase extraction coupled with photodiode‐array and fluorescence detection for chemotaxonomy of isoflavone phytoestrogens in Trifolium L. (Clover) species
Authors: Zgórka Grazyna 
Published: February 2009

AbstractDetailed chemotaxonomic studies were undertaken to establish the qualitative profile and real amounts of the pharmacologically active isoflavone aglycones genistein, daidzein, formononetin, and biochanin A in aerial parts of thirteen Trifolium L. (clover) species, native to Poland. A newly elaborated micropreparative technique – SPE – on BakerBond octadecyl, cyclohexyl, and phenyl cartridges was used in combination with ultrasound‐assisted extraction for isolation of isoflavone aglycones from hydrolyzed samples. The effectiveness of all three SPE sorbents in the purification of plant extracts was compared and very high recoveries (>96%) were documented for four isoflavones. Classical photodiode‐array and very sensitive fluorescence detection, coupled with reversed‐phase high‐performance liquid chromatography (RP‐HPLC), were employed to obtain the most reliable qualitative and quantitative results. Chemotaxonomic differences combined with flower color variability were demonstrated within thirteen clover species. Concentration levels of particular isoflavones in ten Trifolium species possessing flowers with white, pink, or purple‐red corolla ranged from ∼︁3 to ∼︁3300 μg/g dry weight, while in three yellow flowering clovers (T. aureum, T. dubium, and T. campestre) isoflavone compounds have not been detected at all. RSD values, determined for intra‐ and inter‐day precision of the quantitative results, were not higher than 6.2% and 7.1%, respectively.
Combination treatment of surgical, post‐traumatic and post‐herpetic scars with ablative lasers followed by fractional laser and non‐ablative laser in Asians
Authors: Lee Yongsoo 
Published: February 2009

AbstractBackground and objectivesScars are usually classified into atrophic scars, hypertrophic scars and keloids. This author would classify atrophic scars as a subclass of non‐hypertrophic scars. In other words, non‐hypertrophic scars encompass atrophic (depressed) scars and flat scars that are literally flat or protrude minimally above the level of adjacent normal skin, because the same treatment protocol can be used for each. It is speculated that ablative lasers can be used to sculpt the contour of scars or to remove a controlled amount of scar tissue, while at the same time, activating a regenerative cascade. On the other hand, fractional and non‐ablative lasers stimulate and/or keep a proliferative phase on, together with other unique beneficial effects of each device.Patients and MethodsThirty non‐hypertrophic facial scars of 24 Asian patients (Fitzpatrick's skin type III–IV) were treated with ablative lasers (pulsed CO2 and Er:YAG) followed by fractional (1,550 nm) laser and non‐ablative (1,450 nm) laser alternatively every 2–3 weeks. Thirty‐one pairs of pre‐ and post‐treatment‐photographs were evaluated independently by three dermatologists and two plastic surgeons, on a scale of 0–100% improvement. If there was no interval change, this was rated 0%. If there was no difference between the treated region and adjacent normal skin, it was rated 100%. The scars (20 post‐traumatic, 6 surgical, 2 post‐herpetic, 2 burn scars) were all over 6 months old.ResultsThe evaluators rated an average improvement of 86.8% (median 90%). Ten of 31 pairs of photographs were rated 100%, one of which was unanimous. Each evaluator rated 2–5 pairs as having 100% improvement.ConclusionThis study shows the possibility that, with appropriate combinations of different lasers, we can expect complete or near‐complete resolution of many types of scars. Further research and data accumulation will help to establish better protocols for each class of scars. Lasers Surg. Med. 41:131–140, 2009. © 2009 Wiley‐Liss, Inc.
Effects of a 1,450 nm diode laser on facial sebum excretion
Authors: Laubach Hans‐Joachim , Astner Susanne , Watanabe Kanna , Clifford Joan , Rius‐Diaz Francisca , Zurakowski David , Manstein Dieter 
Published: February 2009

AbstractBackground and ObjectiveLaser therapy with a 1,450 nm diode laser is a clinically effective treatment for acne vulgaris, although the mechanism of action is unknown. To investigate this, we conducted a small, prospective, controlled clinical trial to assess this laser's effects on the facial sebum excretion rate (SER).Materials and MethodsFourteen healthy volunteers without active acne were enrolled in this study and received three laser treatments on test areas of the nose and forehead. Nine subjects completed the treatment regimen and were available for follow‐up. SER was measured with Sebumeter® prior to the first treatment, and at 1 week and 1 month after the third treatment. Photographs were taken and subjective assessment of skin oiliness and pore size determined by questionnaires at 1 month follow‐up.ResultsNo significant reduction in SER was observed comparing treated with control on all treatment sites (P>0.05) on the nose. Reduction in the absolute SER was observed for both test and control sites on the forehead, reaching significance on the treatment site (P = 0.04) and marginal significance on the control site (P = 0.08).ConclusionWhile our study was designed to detect only large changes in SER, we conclude that three 1,450 nm laser treatment sessions did not cause marked changes in SER compared to the control (i.e., >44%). Thus, major destruction of sebaceous glands as a result of this treatment is unlikely. However, reduced sebum production was observed on both treatment and control sides at 1 month. Therefore alternative mechanisms should also be considered to explain the clinical efficacy of this treatment for acne vulgaris. Lasers Surg. Med. 41:110–115, 2009. © 2009 Wiley‐Liss, Inc.
Treatment of traumatic scars using plasma skin regeneration (PSR) system
Authors: Kono Taro , Groff William Frederick , Sakurai Hiroyuki , Yamaki Takashi , Soejima Kazukata , Nozaki Motohiro 
Published: February 2009

AbstractObjectivesSeveral modalities have been advocated to treat traumatic scars, including surgical techniques and laser resurfacing. Recently, a plasma skin regeneration (PSR) system has been investigated. There are no reports on plasma treatment of traumatic scars. The objective of our study is to evaluate the effectiveness and complications of plasma treatment of traumatic scars in Asian patients.Materials and MethodsTwenty Asian patients with traumatic scars were enrolled in the study. Three treatments were performed at monthly intervals with PSR, using energy settings of 2 to 3J. Patients were seen 1 week after each individual treatment and 3 months after the last treatment. Improvement was determined by patient questionnaires and physician evaluation of digital photographs taken prior to treatment and at 3 months post‐treatment. The patients were also evaluated for any side effects from the treatment.ResultsNine of 20 patients showed more than 50% improvement. The average pain score on a 10 point scale was 5.8±1.3 SD and all patients tolerated the treatments. The average re‐epithelization time was 7.3±2.8 SD days. Temporary and local hyperpigmentation was observed in four patients and this hyperpigmentation disappeared within 3 months. Hypopigmentation and worsening of scarring were not observed.ConclusionsPlasma treatment is clinically effective and is associated with minimal complications when used to treat traumatic scars in Asian patients. However, deep traumatic scars are resistant to plasma treatment. Lasers Surg. Med. 41:128–130, 2009. © 2009 Wiley‐Liss, Inc.