bluuebunny/crossref_metadata_2025_split huggingface dataset:
Closed-form expressions of the run-length distribution of the nonparametric double sampling precedence monitoring scheme
Authors: Magagula Zwelakhe , Malela-Majika Jean-Claude , Human Schalk William , Castagliola Philippe , Chatterjee Kashinath , Koukouvinos Christos 
Published: April 2024

Abstract
A significant challenge in statistical process monitoring (SPM) is to find exact and closed-form expressions (CFEs) (i.e. formed with constants, variables and a finite set of essential functions connected by arithmetic operations and function composition) for the run-length properties such as the average run-length (

$$ARL$$

ARL

), the standard deviation of the run-length (

$$SDRL$$

SDRL

), and the percentiles of the run-length (

$$PRL$$

PRL

) of nonparametric monitoring schemes. Most of the properties of these schemes are usually evaluated using simulation techniques. Although simulation techniques are helpful when the expression for the run-length is complicated, their shortfall is that they require a high number of replications to reach reasonably accurate answers. Consequently, they take too much computational time compared to other methods, such as the Markov chain method or integration techniques, and even with many replications, the results are always affected by simulation error and may result in an inaccurate estimation. In this paper, closed-form expressions of the run-length properties for the nonparametric double sampling precedence monitoring scheme are derived and used to evaluate its ability to detect shifts in the location parameter. The computational times of the run-length properties for the CFE and the simulation approach are compared under different scenarios. It is found that the proposed approach requires less computational time compared to the simulation approach. Moreover, once derived, CFEs have the added advantage of ease of implementation, cutting off on complex convergence techniques. CFE's can also easily be built into mathematical software for ease of computation and may be recalled for further work.
On the gradient rearrangement of functions
Authors: Amato Vincenzo , Gentile Andrea , Nitsch Carlo , Trombetti Cristina 
Published: April 2024

AbstractIn this paper, we introduce a symmetrization technique for the gradient of a $$\text {BV}$$
BV
function, which separates its absolutely continuous part from its singular part (sum of jump and Cantorian part). In particular, we prove a $$\text {L }^{\text {1}}$$

L

1

comparison between the function and the symmetrization just mentioned. Furthermore, we apply this result to obtain Saint-Venant type inequalities for some geometric functionals.
Unfolding and injectivity of the Kudla–Millson lift of genus 1
Authors: Zuffetti Riccardo 
Published: April 2024

AbstractWe unfold the theta integrals defining the Kudla–Millson lift of genus 1 associated to even lattices of signature (b, 2), where $$b>2$$

b
>
2

. This enables us to compute the Fourier expansion of such defining integrals and prove the injectivity of the Kudla–Millson lift. Although the latter result has been already proved in [5], our new procedure has the advantage of paving the ground for a strategy to prove the injectivity of the lift also for the cases of general signature and of genus greater than 1.
Locally free Caldero–Chapoton functions via reflections
Authors: Mou Lang 
Published: April 2024

AbstractWe study the reflections of locally free Caldero–Chapoton functions associated to representations of Geiß–Leclerc–Schröer’s quivers with relations for symmetrizable Cartan matrices. We prove that for rank 2 cluster algebras, non-initial cluster variables are expressed as locally free Caldero–Chapoton functions of locally free indecomposable rigid representations. Our method gives rise to a new proof of the locally free Caldero–Chapoton formulas obtained by Geiß–Leclerc–Schröer in Dynkin cases. For general acyclic skew-symmetrizable cluster algebras, we prove the formula for any non-initial cluster variable obtained by almost sink and source mutations.
Prognostic value of radiological T category using conventional MRI in patients with oral tongue cancer: comparison with pathological T category
Authors: Kawaguchi Masaya , Kato Hiroki , Kanayama Tomohiro , Tomita Hiroyuki , Hara Akira , Shibata Hirofumi , Ogawa Takenori , Hatakeyama Daijiro , Yamada Yoichi , Ando Tomohiro , Noda Yoshifumi , Hyodo Fuminori , Matsuo Masayuki 
Published: April 2024

Abstract
Purpose
This study aimed to compare the radiological tumor (T)-category using multiparametric MRI with the pathological T category in patients with oral tongue squamous cell carcinoma (OTSCC) and to examine which is a better predictor of prognosis.

Methods
This retrospective study included 110 consecutive patients with surgically resected primary OTSCC who underwent preoperative contrast-enhanced MRI. T categories determined by maximum diameter and depth of invasion were retrospectively assessed based on the pathological specimen and multiparametric MRI. The MRI assessment included the axial and coronal T1-weighted image (T1WI), axial T2-weighted image (T2WI), coronal fat-suppressed T2WI, and axial and coronal fat-suppressed contrast-enhanced T1WI (CET1WI). Axial and coronal CET1WI measurements were divided into two groups: measurements excluding peritumoral enhancement (MEP) and measurements including peritumoral enhancement. The prognostic values for recurrence and disease-specific survival after radiological and pathological T categorization of cases into T1/T2 and T3/T4 groups were compared.

Results
The T category of MEP on coronal CET1WI was the most relevant prognostic factor for recurrence [hazard ratio (HR) = 3.30, p = 0.001] and the HR was higher than the HR for pathological assessment (HR = 2.26, p = 0.026). The T category determined by MEP on coronal CET1WI was also the most relevant prognostic factor for disease-specific survival (HR = 3.12, p = 0.03), and the HR was higher than the HR for pathological assessment (HR = 2.02, p = 0.20).

Conclusion
The T category determined by MEP on the coronal CET1WI was the best prognostic factor among all radiological and pathological T category measurements.
Pectate lyase genes from Radopholus similis and their application in pathotype identification
Authors: Yang Sihua , Yang Shuai , Li Qianying , Lu Yang , Huang Xin , Chen Chun , Xu Chunling , Xie Hui 
Published: April 2024

Abstract
Radopholus similis is a destructive, migratory, and endophytoparasitic nematode. It has two morphologically indistinguishable pathotypes (or physiological races): banana and citrus pathotypes. At present, the only reliable method to differentiate the two pathotypes is testing the infestation and parasitism of nematodes on Citrus spp. via inoculation. However, differences in inoculation methods and conditions adopted by different researchers complicate obtaining consistent results. In this study, the parasitism and pathogenicity of 10 R. similis populations on rough lemon (Citrus limon) seedlings and the tropism and invasion of rough lemon roots were tested. It revealed that populations SWK, GJ, FZ, GZ, DBSR, and YJ were citrus pathotypes, which showed parasitism and pathogenicity on rough lemon and could invade rough lemon roots, whereas populations XIN, ML, HN6, and HL were banana pathotypes, having no parasitism and pathogenicity on rough lemon and they did not invade the rough lemon roots. Four pectate lyase genes (Rs-pel-2, Rs-pel-3, Rs-pel-4, and Rs-pel-5) belonging to the Class III family from these populations were amplified and analysed. The gene Rs-pel-3 could be amplified from six citrus pathotype populations and was stably expressed in the four developmental stages of the nematode, whereas it could not be amplified from the four banana pathotypes. Rs-pel-3 expression may be related to the parasitism and pathogenicity of R. similis on rough lemon. Hence, it can be used as a molecular marker to distinguish between banana and citrus pathotypes and as a target gene for the molecular identification of these two pathotypes.

Key points
• Four pectate lyase genes (Rs-pels) from Radopholus similis were cloned and analysed.
• The expression of Rs-pels is different in two pathotypes of Radopholus similis.
• A molecular identification method for two pathotypes of Radopholus similis using pectate lyase gene Rs-pel-3 as the target gene was established.
Pain catastrophizing in rheumatic diseases: prevalence, origin, and implications
Authors: Wilk Mateusz , Zimba Olena , Haugeberg Glenn , Korkosz Mariusz 
Published: April 2024

AbstractPain is a crucial factor in rheumatic disorders, and reducing it is a primary goal of successful treatment. Adaptive pain-coping strategies can enhance this improvement, but maladaptive approaches such as pain catastrophizing may worsen overall patient well-being. This narrative review aims to provide a concise overview of the existing knowledge on pain catastrophizing in the most prevalent specific rheumatic disorders. The objective of this study was to improve understanding of this phenomenon and its implications, as well as to pinpoint potential directions for future research. We conducted searches in the MEDLINE/PubMed, SCOPUS, and DOAJ bibliography databases to identify articles related to pain catastrophizing in rheumatoid arthritis, psoriatic arthritis, axial spondylarthritis, systemic sclerosis, systemic lupus erythematosus, Sjögren’s syndrome, juvenile idiopathic arthritis, and osteoarthritis (non-surgical treatment). Data extraction was performed on November 1, 2023. The investigators screened the identified articles to determine their relevance and whether they met the inclusion criteria. Following a bibliography search, which was further expanded by screening of citations and references, we included 156 records in the current review. The full-text analysis centred on pain catastrophizing, encompassing its prevalence, pathogenesis, and impact. The review established the role of catastrophizing in amplifying pain and diminishing various aspects of general well-being. Also, potential treatment approaches were discussed and summarised across the examined disorders. Pain catastrophizing is as a significant factor in rheumatic disorders. Its impact warrants further exploration through prospective controlled trials to enhance global patient outcomes.
Expected Energy of Zeros of Elliptic Polynomials
Authors: Torre Víctor de la , Marzo Jordi 
Published: April 2024

AbstractIn 2011, Armentano, Beltrán and Shub obtained a closed expression for the expected logarithmic energy of the random point process on the sphere given by the roots of random elliptic polynomials. We consider a different approach which allows us to extend the study to the Riesz energies and to compute the expected separation distance.
Two-row, three-row or powered circular stapler, which to choose when performing colorectal anastomosis? A systematic review and meta-analysis
Authors: Martín-Arévalo José , Pla-Martí Vicente , Huntley Dixie , García-Botello Stephanie , Pérez-Santiago Leticia , Izquierdo-Moreno A. , Garzón-Hernández LP. , Garcés-Albir M. , Espí-Macías A. , Moro-Valdezate David 
Published: April 2024

Abstract
Purpose
Three types of circular staplers can be used to perform a colorectal anastomosis: two-row (MCS), three-row (TRCS) and powered (PCS) devices. The objective of this meta-analysis has been to provide the existing evidence on which of these circular staplers would have a lower risk of presenting a leak (AL) and/or anastomotic bleeding (AB).

Methods
An in-depth search was carried out in the electronic bibliographic databases Embase, PubMed and SCOPUS. Observational studies were included, since randomized clinical trials comparing circular staplers were not found.

Results
In the case of AL, seven studies met the inclusion criteria in the PCS group and four in the TRCS group. In the case of AB, only four studies could be included in the analysis in the PCS group. The AL OR reported for PCS was 0.402 (95%-confidence interval (95%-CI): 0.266–0.608) and for AB: 0.2 (95% CI: 0.08–0.52). The OR obtained for AL in TRCS was 0.446 (95%-CI: 0.217 to 0.916). Risk difference for AL in PCS was − 0.06 (95% CI: − 0.07 to − 0.04) and in TRCS was − 0.04 (95%-CI: − 0.08 to − 0.01). Subgroup analysis did not report significant differences between groups. On the other hand, the AB OR obtained for PCS was 0.2 (95% CI: 0.08–0.52). In this case, no significant differences were observed in subgroup analysis.

Conclusion
PCS presented a significantly lower risk of leakage and anastomotic bleeding while TRCS only demonstrated a risk reduction in AL. Risk difference of AL was superior in the PCS than in TRCS.
Risk factors for femoral stem fracture following total hip arthroplasty: a systematic review and meta analysis
Authors: Turnbull Gareth S. , Soete Sam , Akhtar Muhammad Adeel , Ballantyne James Anderson 
Published: April 2024

Abstract
Background
Femoral stem fracture following total hip arthroplasty (THA) is an infrequent but nevertheless devastating complication, with an increasing worldwide prevalence as demand for primary THA continues to increase. The aim of this study was to perform a systematic review and meta-analysis of risk factors for femoral stem fracture to help identify at risk patients.

Methods
A systematic search was conducted on EMBASE, MEDLINE and AMED to identify relevant studies. Data regarding study design, source, population, intervention, and outcomes was collated. Data extraction was performed on a custom form generated using Cochrane recommended methodology and analysis of risk factors performed including odds ratios (ORs) with 95% confidence intervals (CIs).

Results
A total of 15 studies reporting a total of 402 stem fractures in 49 723 THAs were identified. The median time from index procedure to stem fracture was 68 months (IQR 42.5–118) whilst mean age at index surgery was 61.8 years (SD 6.9). Male gender (OR = 3.27, 95% CI = 2.59–4.13, p < 0.001), patient weight above 80 kg (OR = 3.55, 95% CI = 2.88–4.37, p < 0.001), age under 63 years (OR = 1.22, 95% CI = 1.01–1.49, p < 0.001), varus stem alignment (OR = 5.77, 95% CI = 3.83–8.7, p < 0.001), use of modular implants (OR = 1.95, 95% CI = 1.56–2.44, p < 0.01) and undergoing revision arthroplasty (OR = 3.33, 95% CI = 2.70–4.1, p < 0.001) were significant risk factors for prosthetic stem fracture. A risk window of 15 years post-surgery was identified.

Conclusions
This review concludes that patient weight, younger age, male sex, varus stem alignment, revision arthroplasty and use of modular stems are significant risk factors for femoral stem fracture. Modifying these risk factors where possible may help reduce incidence of femoral stem fracture in at risk patients.
A brief history of the Feulgen reaction
Authors: Biggiogera Marco , Cavallo Margherita , Casali Claudio 
Published: April 2024

AbstractOne hundred years ago, Robert Feulgen published a landmark paper in which he described the first method to stain DNA in cells and tissues. Although a century has passed since the discovery by Feulgen and Rossenbeck, the chemical reaction still exerts an important influence in current histochemical studies. Its contribution in diverse fields, spanning from biomedicine to plant biology, has paved the way for the most significant studies that constitute our current knowledge. The possibility to specifically explore the DNA in cell nuclei while quantifying its content makes it a contemporary and timeless method. Indeed, many histocytochemical studies following the 1924 paper have led to a deep understanding of genome organization in general as well as several specific mechanisms (e.g. DNA duplication or tumour pathology) that, nowadays, constitute some of the most fundamental pillars in biological investigations. In this review, we discuss the chemistry and application of the Feulgen reaction to both light and electron microscopy.
Preoperative anaemia in distal pancreatectomy: a propensity-score matched analysis
Authors: Radulova-Mauersberger Olga , von Bechtolsheim Felix , Teske Christian , Hempel Sebastian , Kroesen Louisa , Pecqueux Mathieu , Kahlert Christoph , Weitz Jürgen , Distler Marius , Oehme Florian 
Published: April 2024

Abstract
Background
Preoperative anaemia is a prevalent morbidity predictor that adversely affects short- and long-term outcomes of patients undergoing surgery. This analysis aimed to investigate preoperative anaemia and its detrimental effects on patients after distal pancreatectomy.

Material and methods
The present study was a propensity-score match analysis of 286 consecutive patients undergoing distal pancreatectomy. Patients were screened for preoperative anaemia and classified according to WHO recommendations. The primary outcome measure was overall morbidity. The secondary endpoints were in-hospital mortality and rehospitalization.

Results
The preoperative anaemia rate before matching was 34.3% (98 patients), and after matching a total of 127 patients (non-anaemic 42 vs. anaemic 85) were included. Anaemic patients had significantly more postoperative major complications (54.1% vs. 23.8%; p < 0.01), a higher comprehensive complication index (26.2 vs. 4.3; p < 0.01), and higher in-hospital mortality rate (14.1% vs. 2.4%; p = 0.04).
Multivariate regression analysis confirmed these findings and identified preoperative anaemia as a strong independent risk factor for postoperative major morbidity (OR 4.047; 95% CI: 1.587–10.320; p < 0.01).

Conclusion
The current propensity-score matched analysis strongly considered preoperative anaemia as a risk factor for major complications following distal pancreatectomy. Therefore, an intense preoperative anaemia workup should be increasingly prioritised.
Bracing in severe skeletally immature adolescent idiopathic scoliosis: does a holding strategy change the surgical plan?
Authors: Ohrt-Nissen Søren , Heegaard M. , Andersen Thomas , Gehrchen M. , Dahl B. , Tøndevold N. 
Published: April 2024

Abstract
Purpose
The purpose of the study was to assess the changes in flexibility during night-time bracing in skeletally immature adolescent idiopathic scoliosis (AIS) with curves in the surgical range.

Materials and methods
We included a consecutive cohort of 89 AIS patients with curves ≥ 45° and an estimated growth potential. All patients were eventually treated with fusion surgery, and all patients had side-bending radiographs prior to both bracing and surgery. Curves were classified as structural or non-structural curves according to Lenke at both timepoints.

Results
The main curve progressed by a mean of 12 ± 10° and the secondary curve by 8 ± 8°. Flexibility of the main curve decreased from 50 ± 19% to 44 ± 19% (p = 0.001) and the underlying curve from 85 ± 21% to 77 ± 22% (p = 0.005). In 69 patients (79%), the Lenke category did not progress during bracing. In 14 patients (15%), the progression in Lenke type occurred in the thoracic region (i.e., Lenke type 1 to type 2), while six patients (7%) progressed in the lumbar region (i.e., type 1 to type 3).
In the 69 patients that did not progress, we found that the last touched vertebra moved distally by one or two levels in 26 patients.

Conclusions
This is the first study to describe that curve flexibility decreases during bracing in severe AIS. However, this had only a modest impact on the surgical strategy. Bracing as a holding strategy can be applied, but the risk of losing flexibility in the lumbar spine should be outweighed against the risks of premature fusion surgery.
Effects of cancer-induced cachexia and administration of l-glutathione on the intestinal mucosa in rat
Authors: Sestak Sabrina Silva , da Motta Lima Fabiana Galvão , de Oliveira Ana Paula , Barateiro Letícia Ganem Rillo Paz , Vieira-Frez Flávia Cristina , de Souza Sara Raquel Garcia , Guarnier Flávia Alessandra , Perles Juliana Vanessa Colombo Martins , Zanoni Jacqueline Nelisis 
Published: April 2024

AbstractWalker-256 tumor is an experimental model known to promote cachexia syndrome, oxidative stress, and systemic inflammation. This study evaluated the duodenal mucosa of rats with Walker-256 tumor administered with 1% l-glutathione, intending to evaluate the damage caused by cancer-associated cachexia in the gastrointestinal tract and the effects of antioxidant administration on mucosal protection. Twenty-four 55-day-old male Wistar rats were distributed into four groups: control (C); control administered with 1% l-glutathione (C-GSH); Walker-256 tumor (W) and Walker-256 tumor administered with 1% l-glutathione (W-GSH). After 14 days of treatment, the duodenum was harvested for morphometric analysis of the mucosa, proliferation, apoptosis, immunostaining of varicosities immunoreactive (IR) to vasoactive intestinal peptide (VIP) and 5-HT-IR cells, and quantification of mast cells and goblet cells. Walker-256 tumor-bearing rats showed cachexia syndrome, mucosal atrophy, reduced cell proliferation, reduced 5-HT-IR cells, and increased goblet cells and VIPergic varicosities, which were not reversed by l-glutathione. On the other hand, l-glutathione caused a reduction of cells in apoptosis and mast cell recruitment, demonstrating a partial recovery of the damage detected in the intestinal mucosa.
Antipsychotic prescribing: national findings of children and adolescents attending mental health services in Ireland
Authors: Driscoll David J. O. , McCarthy Suzanne 
Published: April 2024

AbstractAntipsychotic prescribing trends vary internationally, albeit off-label use remains high (i.e., target symptoms). We aim to describe antipsychotic use, target conditions, target symptoms and dosing regimens in children and adolescents in Ireland. We used a sampled cohort from a national audit of children and adolescents attending mental health services with predefined inclusion and exclusion criteria from Jul-2021 to Dec-2021 who were prescribed at least one psychotropic medication and up to and including 17-years of age (n = 3528). Each service provided anonymised data. We described the frequency of antipsychotic medication, medication type, target condition, target symptom and medication doses. We used multivariable logistic regression, adjusted with available co-variates to assess the association of being prescribed an antipsychotic medication. Twelve percentage (n = 437) were prescribed an antipsychotic and 16–17-years (n = 211, 48.3%) was the most common age category. The commonest reason for prescribing an antipsychotic was target symptoms (i.e., off-label use) (n = 329; 75.%) and of these symptoms, agitation (n = 77/329; 25%) and irritability (56/239; 25%) were the most common. Quetiapine (n = 127; 29%) was the most common antipsychotic, followed by risperidone (n = 125; 28.6%), aripiprazole (n = 107; 24.5%), and olanzapine (n = 66; 15.1%). In adjusted analysis, having a psychotic disorder ((adjusted-odds-ratio) aOR: 39.63, CI 95%, 13.40–117.22), bipolar disorder (aOR: 16.96, CI 95%, 3.60–80.00), autism spectrum disorder (aOR: 3.24, CI 95%, 2.45–4.28) or aggression symptoms (aOR: 16.75, CI 95%, 7.22–38.89) was associated with prescribing an antipsychotic medication. This is the first study in children and adolescents that describes the target conditions and target symptoms for antipsychotic use in Ireland. Our results show a high proportion of antipsychotic prescribing based on target symptoms rather than target condition or diagnosis.