bluuebunny/crossref_metadata_2025_split huggingface dataset:
A case of POEMS syndrome comprising of a complicated diagnostic procedure: Case report
Authors: Huang Hai-Ping , Ran Hong-Mei , Li Zheng-Sheng , Xie Juan 
Published: March 2024

Rationale:
This article presents the case of a patient with recurrent chronic diarrhea and cachexia who was misdiagnosed, followed by a literature review to summarize the reasons for misdiagnosis of POEMS syndrome and the treatment strategies.

Patient concerns:
The diagnosis and treatment of this patient suggest that with the improvement of M-protein detection levels, the diagnosis of patients with low M-protein levels, such as those with POEMS syndrome, has been greatly aided.

Diagnoses:
POEMS syndrome requires polyneuropathy and monoclonal plasma cell proliferation as mandatory diagnostic criteria. Therefore, patients presenting with polyneuropathy should routinely undergo M-protein testing and consider the possibility of POEMS syndrome.

Interventions:
The patient, in this case, was treated primarily with relatively conservative immunomodulatory agents.

Outcomes:
During follow-up after treatment, the patient’s diarrhea and malnutrition showed significant improvement.

Lessons subsections:
POEMS syndrome has low clinical specificity and a high rate of misdiagnosis. However, once a definitive diagnosis is made, the treatment outcome is favorable.
Application of enhanced recovery after surgery in perioperative nursing care of elderly patients with hip and knee arthroplasty: A systematic review and meta-analysis
Authors: Zhang Mingzhu , Gong Shi-guo , Xie Ronghui 
Published: March 2024

Background:
To collect data from randomized controlled trials (RCTs) to evaluate the effects of enhanced recovery after surgery on postoperative recovery of elderly patients who underwent hip or knee arthroplasty.

Methods:
The search was limited to studies published prior to January 1, 2023, in the electronic databases of Cochrane, Embase, Ovid Medline, Proquest, PubMed, Scopus, Web of Science, and Chinese databases, including China National Knowledge Internet (CNKI) and SinoMed. All relevant data were collected from the studies that met the inclusion criteria. The outcome variables were recovery of joint function and incidence of complications. STATA software (version 14.0) was used for the meta-analysis.

Results:
A total of 44 published studies met the inclusion criteria. The cumulative data included 2203 cases receiving enhanced recovery after surgery (ERAS), and 2173 cases receiving traditional recovery after surgery (non-ERAS). The meta-analysis showed that the VAS score was significantly lower in the ERAS group than in the non-ERAS group (P < .01), and there were fewer incidences of complications in the ERAS group than in the control group (P < .01).

Conclusions:
ERAS significantly reduced pain and the incidence of complications in elderly patients who had undergone joint replacement surgery.
Effectiveness of Taohong Siwu decoction in the prevention of deep vein thrombosis in hip surgery patients: A systematic review and meta-analysis of randomized controlled trials
Authors: Cai Ningning , Han Yabing , Wang Gang , Huang Xiongfeng , Bo Xueping , Qin Han 
Published: March 2024

Background:
This systematic review and meta-analysis aimed to evaluate the effects of Taohong Siwu Decoction (THSWD) combined with low molecular weight heparin (LMWH), as well as THSWD alone, on the incidence of Deep vein thrombosis (DVT), D-dimer levels, prothrombin time (PT), activated partial thromboplastin time (APTT), visual analogue scale (VAS) pain score, and calf swelling in patients undergoing hip fracture or replacement surgery, compared to LMWH.

Methods:
According to the predefined inclusion criteria, we conducted a comprehensive search for randomized controlled trials (RCTs) examining the efficacy of THSWD combined with LMWH or THSWD compared to LMWH in patients with hip fractures or undergoing replacement surgery. The search was performed across multiple databases including China National Knowledge Internet, WanFang, Sinomed, Duxiu, PubMed, Embase, Google Scholar, Cochrane, and Web of Science from their inception until December 2023. Additionally, relevant literature references were retrieved and hand searching of pertinent journals was conducted. The methodological quality assessment of the included trials was carried out following the guidelines outlined in the Cochrane Handbook. Review Manager 5.4 was applied in analyzing and synthesizing.

Results:
A total of 18 RCTs with 1353 patients were included. The results of meta-analysis showed that compared with the control group, the combined group had a better effect on the incidence of DVT [RR = 0.32, 95% CI(0.17, 0.58; P = .0002], D-dimer [SMD = −5.88, 95% CI(−7.66, −4.11); P < .00001], VAS [MD = −1.16, 95% CI(−1.81, −0.50); P = .0005], Calf circumference difference [MD = −0.56, 95% CI(−1.05, −0.08); P = .02]. There was no significant difference in PT and APTT between the combined group and the control group. Meta-analysis results show that the D-dimer, incidence of DVT, PT, and APTT did not significantly differ between the THSWD and the LMWH groups.

Conclusion:
This meta-analysis shows that compared with LMWH, THSWD combined with LMWH has a better efficacy in the treatment of DVT after hip surgery, without a significant increase in the incidence of adverse events. Additionally, the combined therapy can also reduce D-dimer, VAS, and swelling. However, due to the limitations of the included studies (such as small sample size and low-quality evidence), the results need to be further verified in more rigorous multicenter clinical trials with a large sample size.
Rhabdomyolysis caused by Botrychium ternatum intoxication: Case report and literature review
Authors: Liu Ming-Wei , Zhang Chun-Hai , Zhang Qiu-Juan , Zhang Bing-Ran 
Published: March 2024

Rationale:

Botrychium ternatum ((Thunb.) Sw.), a traditional Chinese medicine, is known for its therapeutic properties in clearing heat, detoxifying, cough suppression, and phlegm elimination. It has been extensively used in clinics for the treatment of many inflammation-related diseases. Currently, there are no documented cases of rhabdomyolysis resulting from Botrychium ternatum intoxication.

Patient concerns:
A 57-year-old male presented with a complaint of low back discomfort accompanied by tea-colored urine lasting for 4 days. The patient also exhibited markedly increased creatine phosphate kinase and myoglobin levels. Prior to the onset of symptoms, the patient consumed 50 g of Botrychium ternatum to alleviate pharyngodynia.

Diagnoses:
The patient was diagnosed with rhabdomyolysis due to Botrychium ternatum intoxication.

Interventions:
The patient underwent a substantial volume of fluid resuscitation, diuresis, and alkalization of urine, as well as correction of the acid-base balance and electrolyte disruption.

Outcomes:
Following a 10-day treatment plan involving massive fluid resuscitation, diuresis, and alkalization of urine, the patient showed notable improvement in his lower back pain and reported the absence of any discomfort. Following reexamination, the levels of creatine phosphate kinase and myoglobin were restored to within the normal ranges. Additionally, no abnormalities were detected in liver or renal function. As a result, the patient was considered eligible for discharge and was monitored.

Conclusions:

Botrychium ternatum intoxication was associated with the development of rhabdomyolysis. To manage this condition, it is recommended that patients provide massive fluid resuscitation, diuresis, alkalization of urine, and other appropriate therapeutic interventions.

Lesson:
Currently, there are no known cases of rhabdomyolysis resulting from Botrychium ternatum intoxication. However, it is important to consider the potential occurrence of rhabdomyolysis resulting from Botrychium ternatum intoxication when there is a correlation between the administration of Botrychium ternatum and the presence of muscular discomfort in the waist or throughout the body, along with tea-colored urine. Considering the levels of creatine phosphate kinase and myoglobin, the diagnosis or exclusion of rhabdomyolysis caused by Botrychium ternatum intoxication should be made, and suitable treatment should be administered accordingly.
Successful diagnosis of asymptomatic choriocarcinoma by ultrasonography during a viable pregnancy: A rare case report
Authors: Gao Qianqian , Luo Hong 
Published: March 2024

Background:
Gestational choriocarcinoma occurs very rare in conjunction with pregnancy and it is camouflage for diagnosis.

Methods:
We present a rare case of asymptomatic choriocarcinoma in a viable pregnancy that was successfully diagnosed by ultrasonography and had timely treatment.

Results:
According to the ultrasonography, early diagnosis and treatment monitoring of choriocarcinoma during a viable pregnancy was administered and the newborn was discharged.

Conclusion:
Choriocarcinoma in pregnancy is camouflaged, and its clinical presentation varies widely. Despite an asymptomatic status, metastasis can occur, and ultrasonography is important for early diagnosis and treatment monitoring.
Brain metastasis in a patient with BRCA2-mutated treatment-related neuroendocrine prostate carcinoma and long-term response to radiotherapy and Olaparib: A case report and literature review
Authors: Uehara Rio , Obinata Daisuke , Hashimoto Sho , Nakahara Ken , Uchida Hideaki , Yoshizawa Tsuyoshi , Mochida Junichi , Yamaguchi Kenya , Sakaguchi Masakuni , Ozawa Yoshinari , Mori Fumi , Miura Katsuhiro , Ishige Toshiyuki , Masuda Shinobu , Nakayama Tomohiro , Takahashi Satoru 
Published: March 2024

Background:
A new subtype of prostate cancer called treatment-related neuroendocrine prostate carcinoma (t-NEPC) was added to the revised World Health Organization classification of prostate cancer in 2022. t-NEPC cases are increasing, and there is no established standard treatment.

Methods:
A 49-year-old male patient was referred to our department for dysuria. A rectal examination and a prostate biopsy revealed stony hardness and prostate adenocarcinoma, respectively. Imaging studies confirmed the presence of multiple bone and lymph node metastases. The patient was started on upfront treatment with androgen deprivation therapy and an androgen receptor signaling inhibitor, which resulted in a significant (>90%) decrease in prostate-specific antigen (PSA) levels. The patient experienced postrenal failure 6 months later, attributable to local disease progression. Concurrently, there was an elevation in neuron-specific enolase (NSE) levels and an enlargement of pelvic lymph node metastases, without PSA progression.

Results:
Biopsy specimen for cancer genome profiling revealed deletion of BRCA 2 and PTEN, AR amplification, and the presence of the TMPRSS2-ERG fusion gene. Based on increased NSE and BRCA2 mutations, a diagnosis of t-NEPC with BRCA2 mutation was eventually made. The patient received docetaxel chemotherapy and pelvic radiotherapy. Subsequently, he was treated with olaparib. His NSE levels decreased, and he achieved a complete response (CR). However, 18 months following the olaparib administration, brain metastases appeared despite the absence of pelvic tumor relapse, and the patient’s PSA levels remained low. Consequently, the patient underwent resection of the brain metastases using gamma knife and whole-brain radiotherapy but died approximately 3 months later.

Conclusion subsections:
Platinum-based chemotherapy is often administered for the treatment of t-NEPC, but there are few reports on the effectiveness of olaparib in patients with BRCA2 mutations. In a literature review, this case demonstrated the longest duration of effectiveness with olaparib alone without platinum-based chemotherapy. Additionally, the occurrence of relatively rare, fatal brain metastases in prostate cancer after a long period of CR suggests the necessity of regular brain imaging examinations.
Successful live birth of thin endometrium: A case report
Authors: Huang Baoyi , Lu Danying , Kong Yanxiang , Ma Lin 
Published: March 2024

Rationale:
The success of pregnancy depends on various factors, with the endometrial receptivity being a crucial component. Endometrial thickness (EMT) serves as a direct indicator for assessing endometrial receptivity. Previous studies have suggested that a thin endometrium is associated with lower pregnancy rates, especially in patients with an EMT of less than 4 mm. Even in assisted reproductive technology cycles with high success rates, clinical pregnancy cases in patients with such thin endometrium are reported to be very few, let alone in natural conception cycles. Therefore, a thin endometrium poses significant challenges for infertility patients. In this study, patients with an extremely thin endometrium were able to achieve clinical pregnancy and successful live births through natural conception, highlighting the possibility of success even in challenging cases.

Patient concerns:
The patient presented with polycystic ovary syndrome and ovulation disorders. She underwent a natural cycle of letrozole-induced ovulation. On the day of the human chorionic gonadotropin trigger, she had an EMT of 3.8 mm.

Diagnoses:
Polycystic ovary syndrome, ovulation disorders, thin endometrium.

Interventions:
The patient received medications including Progynova, Aspirin, and Dydrogesterone.

Outcomes:
The patient achieved spontaneous conception and subsequently had a live birth.

Lessons:
This case report underscores the significance of managing a thin endometrium during letrozole-induced ovulation. While EMT is traditionally pivotal for predicting embryo implantation success, our findings indicate that endometrial receptivity extends beyond thickness alone. Factors such as endometrial morphology, type, and blood supply play crucial roles. Successful pregnancies with a 3.8 mm EMT are rare, making this case a beacon of hope for such patients. It highlights that, with appropriate interventions, successful pregnancies remain attainable. For those with a thin endometrium, emphasis should extend beyond thickness, addressing ways to enhance both endometrial blood supply and morphology for improved pregnancy rates.
When Equality Is Not Equity
Authors: Strong Bethany L. , Cosey-Gay Franklin , Wilson Kenneth L. , Rogers Selwyn O. 
Published: March 2024

Objective:
The purpose of this surgical perspective is to describe the trauma care needs of the South Side of Chicago and the creation of an adult trauma center at the University of Chicago Medicine and associated hospital-based violence intervention program.

Summary Background Data:
Traumatic injury is a leading cause of death and disability in the US. Disparities across the continuum of trauma care exist, which are often rooted in the social determinants of health. Trauma center distribution is critical to timely treatment and should be based on the trauma needs of the area. The previous trauma ecosystem of Chicago was incongruent with the concentration of violent injuries on the south and west sides of the city leading to a fallacy of distributive justice.

Methods:
A descriptive analysis of community partners, trauma program leadership, trauma surgeons and the violence intervention program director was performed.

Results:
The UCM trauma center opened in May 2018 and has since been one of the busiest trauma centers in the country with a 40% penetrating trauma rate. There have been significant reductions in patient transport time on the South Side up to 8.9 minutes (P<0.001). The violence intervention program employs credible messengers with lived experience representing the community and has engaged over 8000 patients since 2018 developing both community-based and medical legal partnerships.

Conclusions:
The persistent efforts of the community and key stakeholders led to a system change improving trauma care for the South Side of Chicago.
Fes-deficient macrophages enhance CD8+T cell priming and tumour control through increased pro-inflammatory cytokine production and localization
Authors: Laight Brian J. , Harper Danielle , Dmytryk Natasha , Zhang Shengnan , Garven Andrew , Shi Changnian , Nauman Richard , Kment Jacob , Alotaibi Faizah , Shapavalov Ivan , Gao Yan , Mewburn Jeff , Vlasschaert Caitlyn , LeBrun David , Tyryshkin Kathrin , Berman David , Simpson Amber , Graham Charles , Craig Andrew W. , Basta Sameh , Koti Madhuri , Greer Peter A. 
Published: March 2024

AbstractHomeostatic immunoregulatory mechanisms that prevent adverse effects of immune overaction can serve as barriers to successful anti-cancer immunity, representing attractive targets to improve cancer immunotherapy. Here, we demonstrate a novel role of the Fes tyrosine kinase, abundantly expressed in immune cells, as an innate intracellular immune checkpoint. Host Fes-deficiency delays tumour onset in a gene dose-dependent manner and improves murine triple negative breast cancer and melanoma tumour control, survival, doxorubicin efficacy, and anti-PD-1 therapy sensitization. These effects were associated with a shift to an anti-tumourigenic tumour immune microenvironment.In vitro, we observed increased Toll-like receptor signaling, and proinflammatory cytokine production and presentation from antigen presenting cells, leading to increased T cell activation, cancer cell killing and tumour control. This study highlights Fes as a novel innate immune checkpoint with potential as a predictive biomarker for effective immune checkpoint blockade treatment, and a potential therapeutic target to improve anti-cancer immunotherapy.
Circulating low-molecular-weight (poly)phenol metabolites in the brain: unveiling in vitro and in vivo blood–brain barrier transport
Authors: Carecho Rafael , Marques Daniela , Carregosa Diogo , Masuero Domenico , Garcia-Aloy Mar , Tramer Federica , Passamonti Sabina , Vrhovsek Urska , Ventura M. Rita , Brito Maria Alexandra , Nunes dos Santos Cláudia , Figueira Inês 
Published: March 2024

AbstractCirculating metabolites resulting from colonic metabolism of dietary (poly)phenols are highly abundant in the bloodstream, though still marginally explored, particularly concerning their brain accessibility. Our goal is to disclose (poly)phenol metabolites’ blood–brain barrier (BBB) transport, in vivo and in vitro, as well as their role at BBB level. For three selected metabolites, benzene-1,2-diol-3-sulfate/benzene-1,3-diol-2-sulfate (pyrogallol-sulfate – Pyr-sulf), benzene-1,3-diol-6-sulfate (phloroglucinol-sulfate – Phlosulf), and phenol-3-sulfate (resorcinol-sulfate – Res-sulf), BBB transport was assessed in human brain microvascular endothelial cells (HBMEC). Their potential in modulating in vitro BBB properties at circulating concentrations was also studied. Metabolites’ fate towards the brain, liver, kidney, urine, and blood was disclosed in Wistar rats upon injection. Transport kinetics in HBMEC highlighted different BBB permeability rates, where Pyr-sulf emerged as the most in vitro BBB permeable metabolite. Pyr-sulf was also the most potent regarding BBB properties improvement, namely increased beta(β)-catenin membrane expression and reduction of zonula occludens-1 membrane gaps. Whereas no differences were observed for transferrin, increased expression of caveolin-1 upon Pyr-sulf and Res-sulf treatments was found. Pyrsulf was also capable of modulating gene and protein expression of some solute carrier transporters. Notably, each of the injected metabolites exhibited a unique tissue distribution in vivo, with the remarkable ability to almost immediately reach the brain.
The Underground World of Plant Disease: How Does Rhizosphere Dysbiosis Affect Plant Health Above-ground?
Authors: Ketehouli Toi , Pasche Josephine , Buttrós Victor Hugo , Goss Erica M. , Martins Samuel J. 
Published: March 2024

ABSTRACTSimilar to the human gut microbiome, diverse microbes colonize the plant rhizosphere, and an imbalance of this microbial community, known as dysbiosis, may negatively impact plant health. This study aimed to investigate the influence of rhizosphere dysbiosis on above-ground plant health using tomato plants (Solanum lycopersicumL.) and the foliar bacterial spot pathogenXanthomonas perforansas model organisms. Four-week-old tomato plant’s rhizospheres were treated with streptomycin (0.6 g × L-1), or water (negative control) and spray-inoculated withX. perforans(105cells × mL-1) after 24 h. Half of the plants treated with streptomycin andX. perforansreceived soil microbiome transplants (SMT) from uninfected plant donors 48 h after streptomycin application. Streptomycin-treated plants showed a 26% increase in disease severity compared to plants that received no antibiotic, while plants that received the SMT had an intermediate level of disease severity. Antibiotic-treated plants showed a reduced abundance of rhizobacterial taxa like Cyanobacteria from the genusCylindrospermumas well as down-regulation of genes related to plant primary and secondary metabolism and up-regulation of plant defense genes associated with induced systemic resistance (ISR). This study highlights the crucial role of beneficial rhizosphere microbes in disease resistance, even to foliar pathogens.
Acute kidney injury triggers hypoxemia by inducing intravascular neutrophil retention that reduces lung capillary blood flow
Authors: Komaru Yohei , Ning Liang , Lama Carine , Suresh Anusha , Kefaloyianni Eirini , Miller Mark J. , Kawana Shinichi , Shepherd Hailey M. , Li Wenjun , Kreisel Daniel , Herrlich Andreas 
Published: March 2024

AbstractSterile acute kidney injury (AKI) is common in the clinic and frequently associated with hypoxemia that does not improve with dialysis and remains incompletely understood. AKI induces remote lung inflammation with neutrophil recruitment in mice and humans, but which cellular cues establish neutrophilic inflammation and how it contributes to hypoxemia is not known. Here we report that AKI induces rapid intravascular neutrophil retention in lung alveolar capillaries without any significant extravasation into tissue or alveoli, causing hypoxemia by reducing lung capillary blood flow in the absence of any significant lung interstitial or alveolar edema. In contrast to direct ischemic lung injury, lung neutrophil recruitment during remote lung inflammation did not require cues from intravascular non-classical monocytes or tissue-resident alveolar macrophages. Instead, lung neutrophil retention depended on neutrophil chemoattractant CXCL2 released by activated intravascular classical monocytes. Comparative single-cell RNA-sequencing analysis of direct and remote lung inflammation revealed that alveolar macrophages are highly activated and produce the neutrophil chemoattractant CXCL2 only in direct lung inflammation. Establishing a CXCL2 gradient into the alveolus by intratracheal administration of CXCL2 during AKI-induced remote lung inflammation enabled neutrophils to extravasate. We thus discovered important differences in lung neutrophil recruitment in direct versus remote lung inflammation and identified lung capillary neutrophil retention that negatively affects oxygenation by causing a ventilation-perfusion mismatch as a novel driver of AKI-induced hypoxemia.