bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anti-inflammatory effect of antidiabetic thiazolidinediones prevents bone resorption rather than cartilage changes in experimental polyarthritis
Authors: Koufany Meriem , Moulin David , Bianchi Arnaud , Muresan Mikhaela , Sebillaud Sylvie , Netter Patrick , Weryha Georges , Jouzeau Jean-Yves 
Published: January 2008

Abstract
Background
Rosiglitazone and pioglitazone are high-affinity peroxisome proliferator-activated receptor (PPAR)-γ agonists with potent anti-diabetic properties and potential anti-inflammatory effects. We compared the ability of a range of oral doses of these thiazolidinediones, including those sufficient to restore insulin sensitization, to inhibit the pathogenesis of adjuvant-induced arthritis (AIA).

Methods
AIA was induced in Lewis rats by a subcutaneous injection of 1 mg of complete Freund's adjuvant. Rats were treated orally for 21 days with pioglitazone 3, 10 or 30 mg/kg/day, rosiglitazone 3 or 10 mg/kg/day, or with vehicle only. The time course of AIA was evaluated by biotelemetry to monitor body temperature and locomotor activity, by clinical score and plethysmographic measurement of hindpaw oedema. At necropsy, RT-PCR analysis was performed on synovium, liver and subcutaneous fat. Changes in cartilage were evaluated by histological examination of ankle joints, radiolabelled sulphate incorporation (proteoglycan synthesis), glycosaminoglycan content (proteoglycan turnover) and aggrecan expression in patellar cartilage. Whole-body bone mineral content was measured by dual-energy X-ray absorptiometry.

Results
The highest doses of rosiglitazone (10 mg/kg/day) or pioglitazone (30 mg/kg/day) were required to reduce fever peaks associated with acute or chronic inflammation, respectively, and to decrease arthritis severity. At these doses, thiazolidinediones reduced synovitis and synovial expression of TNF-α, IL-1β and basic fibroblast growth factor without affecting neovascularization or the expression of vascular endothelial growth factor. Thiazolidinediones failed to prevent cartilage lesions and arthritis-induced inhibition of proteoglycan synthesis, aggrecan mRNA level or glycosaminoglycan content in patellar cartilage, but reduced bone erosions and inflammatory bone loss. A trend towards lower urinary levels of deoxipyridinolin was also noted in arthritic rats treated with thiazolidinediones. Rosiglitazone 10 mg/kg/day or pioglitazone 30 mg/kg/day increased the expression of PPAR-γ and adiponectin in adipose tissue, confirming that they were activating PPAR-γ in inflammatory conditions, although an increase in fat mass percentage was observed for the most anti-arthritic dose.

Conclusion
These data emphasize that higher dosages of thiazolidinediones are required for the treatment of arthritis than for restoring insulin sensitivity but that thiazolidinediones prevent inflammatory bone loss despite exposing animals to increased fatness possibly resulting from excessive activation of PPAR-γ.
Impact of invasive fungal infection on outcomes of severe sepsis: a multicenter matched cohort study in critically ill surgical patients
Authors: Xie Guo-Hao , Fang Xiang-Ming , Fang Qiang , Wu Xin-Min , Jin Yu-Hong , Wang Jun-Lu , Guo Qu-Lian , Gu Miao-Ning , Xu Qiu-Ping , Wang Dong-Xin , Yao Shang-Long , Yuan Shi-Ying , Du Zhao-Hui , Sun Yun-Bo , Wang Hai-Hong , Wu Shui-Jing , Cheng Bao-Li 
Published: January 2008

Abstract
Introduction
Fungal infection is increasingly common in critical illness with severe sepsis, but the influence of invasive fungal infection (IFI) on severe sepsis is not well understood. The aim of this study was to investigate the impact that IFI has on the outcomes of critically ill surgical patients with severe sepsis in China by means of matched cohort analysis; we also evaluated the epidemiologic characteristics of IFI in this population.

Methods
Records for all admissions to 10 university hospital surgical intensive care units (ICUs) from December 2004 to November 2005 were reviewed. Patients who met criteria for severe sepsis were included. IFI was identified using established criteria based on microbiologic or histological evidence. A matched cohort study was conducted to analyze the relationship between IFI and outcomes of severe sepsis.

Results
A total of 318 patients with severe sepsis were enrolled during the study period, of whom 90 (28.3%) were identified as having IFI. A total of 100 strains of fungi (58% Candida albicans) were isolated from these patients. Independent risk factors for IFI in patients with severe sepsis included mechanical ventilation (>3 days), Acute Physiology and Chronic Health Evaluation score, coexisting infection with both Gram-positive and Gram-negative bacteria, and urethral catheterization (>3 days). Compared with the control cohort, IFI was associated with increased hospital mortality (P < 0.001), high hospital costs (P = 0.038), and prolonged stay in the ICU (P < 0.001) and hospital (P = 0.020).

Conclusion
IFI is frequent in patients with severe sepsis in surgical ICUs and is associated with excess risk for hospital mortality, longer ICU and hospital stays, and greater consumption of medical resources.
Roles of Clinical Criteria, Computed Tomography Scan, and Adrenal Vein Sampling in Differential Diagnosis of Primary Aldosteronism Subtypes
Authors: Mulatero Paolo , Bertello Chiara , Rossato Denis , Mengozzi Giulio , Milan Alberto , Garrone Corrado , Giraudo Giuseppe , Passarino Giorgio , Garabello Domenica , Verhovez Andrea , Rabbia Franco , Veglio Franco 
Published: January 2008

Abstract
Context: In patients with primary aldosteronism (PA), it is fundamental to distinguish between subtypes that benefit from different therapies. Computed tomography (CT) scans lack sensitivity and specificity and must be followed by adrenal venous sampling (AVS). Because AVS is not widely available, a list of clinical criteria that indicate the presence of an aldosterone-producing adenoma (APA) has been suggested.
Objective and Design: The objective of the study was to test the sensitivity and specificity of the last generation CT scans, test prospectively the usefulness of clinical criteria in the diagnosis of APA, and develop a flow chart to be used when AVS is not easily available.
Setting: Hypertensive patients referred to our hypertension unit were included in our study.
Patients: Seventy-one patients with confirmed PA participated in our study.
Intervention: All patients had a CT scan and underwent AVS.
Main Outcome Measure: Final diagnosis of APA was the main measure.
Results: A total of 44 and 56% of patients were diagnosed as having an APA and a bilateral adrenal hyperplasia (BAH), respectively. Twenty percent of patients with PA displayed hypokalemia. CT scans displayed a sensitivity of 0.87 and a specificity of 0.71. The posture test displayed a lower sensitivity and specificity (0.64 and 0.70, respectively). The distribution grades of hypertension were not significantly different between APA and BAH. Biochemical criteria of high probability of APA displayed a sensitivity of 0.32 and a specificity of 0.95.
Conclusions: This study underlines the central role of AVS in the subtype diagnosis of PA. The use of the clinical criteria to distinguish between APA and BAH did not display a satisfactory diagnostic power.
Medication Adherence Following Coronary Artery Bypass Graft Surgery: Assessment of Beliefs and Attitudes
Authors: Khanderia Ujjaini , Townsend Kevin A , Erickson Steven R , Vlasnik Jon , Prager Richard L , Eagle Kim A 
Published: January 2008

Background: The medication management of patients following coronary artery bypass graft (CABG) surgery may include antiplatelet agents, β-blockers. angio-tensin-converting enzyme inhibitors, and statins. However, poor adherence is common, and patient attitudes and beliefs ptay a role in adherence. Objective: To evaluate the association between self-reported adherence and the beliefs patients have about cardiovascular medicines used after CABG. Methods: Adults were surveyed 6–24 months following CABG. The validated Beliefs about Medicines Questionnaire (BMQ) assessed attitudes concerning the Specific Necessity, Specific Concerns, General Harm, and General Overuse of medicines. The validated medication adherence scale assessed self-reported adherence. Analysis included univariate comparison (BMQ scales) and multivariate logistic regression (identification of adherence predictor variables). Results: Of 387 patients surveyed, 132 (34%) completed the questionnaire. Nonparticipants were more likely to be female and have undergone 1- or 2-vessel CABG procedures compared with 3- or 4-vessel procedures. Subjects were primarily English-speaking, white, and male. Adherent behavior was reported in 73 of 132 patients (55%). The average period between CABG and the survey was 16 months. Nonadherent patients were in stronger agreement on the General Overuse (p = 0.01) and General Harm (p = 0.04) scales. The adjusted odds of adherent behavior were significantly lower, with an increasing General Overuse score (OR 0.83; 95% CI 0.72 to 0.95; p = 0.007); an annual income of $50,000 to $100,000 relative to less than $20,000 (OR 0.36; 95% CI 0.14 to 0.91; p = 0.031), and a living status of “alone” compared with “with adults and no children” (OR 0.20; 95% CI 0.06 to 0.65; p = 0.007). The odds ratio of self-reported adherence was higher with increasing age (OR 1.05; 95% CI 1.01 to 1.09; p = 0.023). Conclusions: In summary, patient beliefs and attitudes regarding medications, along with other social, economic, and demographic factors, help explain differences in self-reported adherence to standard drug therapy following CABG.
Potential Use of Statins to Prevent Atrial Fibrillation After Coronary Artery Bypass Surgery
Authors: Howard Patricia A , Barnes Brian J 
Published: January 2008

Objective: To review the published literature evaluating the effectiveness of statin therapy for preventing postoperative atrial fibrillation (POAF) after coronary artery bypass graft (CABG) surgery, Data Sources: A MEDLINE search was performed (1950–October 2007) using the search terms statins, HMG-CoA reductase inhibitors, coronary artery bypass graft, cardiac surgery, and atrial fibrillation, Study Selection and Data Extraction: All articles published in English describing or evaluating the use of statins in humans to prevent atrial fibrillation (AF) were included. Additional pertinent articles were identified from reference lists. Data Synthesis: POAF is a common complication following CABG surgery that is associated with significant morbidity. Current preventive strategies include the use of β-blockers and antiarrhythmic drugs such as amiodarono and Sotalol. Accumulating evidence suggests that statins may also reduce the risk of POAF. Numerous studies in nonsurgical cardiovascular patients have found reduced rates of AF with statins. In patients who have undergone CABG, several observational studies have also documented benefit. One randomized controlled trial reported a significant reduction in the risk of POAF and reduced length of hospital stay in patients given preoperative atorvastatin beginning 7 days before surgery. Ongoing research suggests that statins may reduce the risk of AF through pleiotropic effects independent of cholesterol lowering such as reductions in inflammation, oxidative damage, neurohormonal activation, and thrombosis. Conclusions: While the current evidence evaluating the use of statins to prevent POAF is encouraging, definitive conclusions cannot be drawn. However, because statins are widely used in cardiac patients for other indications and are not associated with the risks inherent to antiarrhythmic drugs, their value as an adjunct to current preventive strategies (or POAF deserves further study. Additional research is needed to examine the effectiveness of statins in risk-stratified patients undergoing CABG surgery and the impact on patient outcomes and attributed costs.
A Broader View of Musical Exoticism
Authors: LOCKE RALPH P. 
Published: January 2008

Most previous writings on musical exoticism reflect the unspoken assumption that a work is perceived by the listener as exotic only if it incorporates distinctively foreign or otherwise highly unusual elements of musical style. This “Exotic Style Only” Paradigm often proves revelatory, especially for purely instrumental works. In operas and other musicodramatic works set in exotic locales, by contrast, music is heard within a narrative “frame” that shapes the listener's response. Yet the existing literature on “the exotic in music” tends to restrict its attention to those few scenes or passages (in such works) that “sound non-Western.” It also tends to leave unmentioned the many Baroque-era operas and dramatic oratorios that focus on despicable Eastern tyrants.
The present article proposes an “All the Music in Full Context” Paradigm to help make sense of a variety of exotic portrayals that are strikingly diverse in message and means: 1) Les Indes galantes (Rameau's application of standard musico-rhetorical devices to manipulative and anti-colonialist speeches by the Peruvian leader Huascar); 2) Belshazzar (Handel's vivid musical setting of the passage in which the cruel, cowardly Eastern despot seeks oblivion in drink); 3) Bizet's Carmen (the Card Scene, which is notably free of Hispanic or other local color yet, through rigidly recurring devices in voice and orchestra, indelibly limns Carmen's Gypsy fatalism); and 4) three prominent dramatic moments, two of them rarely discussed, in Puccini's Madama Butterfly. In each case, the full range of artistic components—including musical devices that lie within or outside the traditional exotic vocabulary—enriches our understanding of how diversely, powerfully, sometimes disturbingly the exoticizing process can function in genres that combine music with dramatic representation.
Esfenvalerate-induced case-abandonment in the larvae of the caddisfly (Brachycentrus americanus)
Authors: Johnson Katherine R , Jepson Paul C , Jenkins Jeffrey J 
Published: January 2008

Abstract
Field-collected Brachycentrus americanus Banks (Trichoptera: Brachycentridae) larvae were used to investigate the relationship between esfenvalerate exposure and case-abandonment response, determine larval ability to construct a new case, and measure the change in predation risk to insects in rebuilt cases. We evaluated case-abandonment following four environmentally relevant esfenvalerate exposures, 0.05, 0.1, 0.2, and 0.4 μg/L; 48-h exposures to 0.2 and 0.4 μg/L (nominal) esfenvalerate both resulted in over 60% of larvae abandoning cases and were statistically indistinguishable. Propensity to engage in building behaviors was significantly diminished in 0.2 and 0.4 μg/L esfenvalerate-exposed insects that had abandoned cases, with less than 20% of exposed insects producing cases. Cases built by intoxicated larvae were characterized by a disorganized composition, and required half the pressure to crush versus cases built by nonexposed larvae. Pre-exposing case-building material to 1 μg/L esfenvalerate also reduced the physical strength of rebuilt cases. Larvae inhabiting weaker rebuilt cases and larvae without cases were significantly more susceptible to predation by second year Hesperoperla pacifica Banks (Plecoptera: Perlidae) stonefly nymphs than those in original cases. Overall, we concluded that small behavioral responses can have profound consequences for survival of species and reveal susceptible stages in life-cycles that can be overlooked by conventional approaches to ecological risk assessment.
Estimating bioconcentration factors, lethal concentrations and critical body residues of metals in the mollusks Perna viridis and Mytilus edulis using ion characteristics
Authors: van Kolck Maurits , Huijbregts Mark A.J , Veltman Karin , Hendriks A. Jan 
Published: January 2008

Abstract
Quantitative structure–activity relationships (QSARs) for metal bioconcentration factors (BCF) and median acute lethal water concentrations (LC50) were developed for two species of mollusks, Perna viridis and Mytilus edulis. These endpoints were related to four metal ion characteristics, the covalent index (χ2mr) (r represents the ion radius in Å), the softness index (σp), the hydrolysis constant (Koh) and the ionic index (Z2/r). The BCF and LC50 were significantly correlated to χ2mr. The coefficients of determination r2 for the relationships with other metal descriptors were much lower. Critical body residue (CBR) QSARs were derived by multiplying the χ2mr-based BCF and LC50 regressions. The CBRs were independent of the covalent index χ2mr, as BCF and LC50 scaled to χ2mr with slope that had opposite signs. Comparison of the estimated CBRs with independent empirical values confirmed the predicted trends, but substantial deviations were noted too.
Molecular cloning of estrogen receptors from fathead minnow (Pimephales promelas) and bluegill (Lepomis macrochirus) fish: Limited piscine variation in estrogen receptor–mediated reporter gene transactivation by xenoestrogens
Authors: Sumida Kayo , Saito Koichi 
Published: January 2008

AbstractEstrogen receptors (ERs) play essential roles in estrogen function. Because they may be targets of environmental chemicals, concern exists that exposure to some anthropogenic agents may result in disruption of endocrine systems in human and wildlife populations. Various kinds of ERs have been reported, and a number of in vitro assays have been established to test hormone-like activity of chemicals. In the present study, cDNAs encoding ERs from fathead minnow (Pimephales promelas) and bluegill (Lepomis macrochirus) fish, which are useful for environmental monitoring, were cloned and sequenced. Four complete, full-length ERα and ERβ cDNA sequences could be derived, with an ATG start site and a TGA termination signal included in each. Fathead minnow ERα has 602 amino acid residues, bluegill ERα1 has 582, bluegill ERα2 has 506, and bluegill ERβ has 554. When the cDNAs were inserted into the pRc/RSV vector and transfected into HeLa cells (derived from cervical cancer cells) with a reporter plasmid, the encoding proteins were confirmed to be functional through interaction of the receptor–ligand complex with the estrogen-responsive element (ERE). Here, we report the analysis of piscine differences in ER-dependent transactivation with some chemicals using reporter gene assays. In agonist assays, fold-induction of luciferase activity significantly varied among ERs, but responsiveness to each chemical demonstrated certain similarities. These reporter gene assays appear to be very useful for estimating adverse effects of chemicals, including hormone-like or antihormone-like activity, in fish.
Degradation kinetics of ptaquiloside in soil and soil solution
Authors: Ovesen Rikke Gleerup , Rasmussen Lars Holm , Hansen Hans Christian Bruun 
Published: January 2008

AbstractPtaquiloside (PTA) is a carcinogenic norsesquiterpene glycoside produced in bracken (Pteridium aquilinum (L.) Kuhn), a widespread, aggressive weed. Transfer of PTA to soil and soil solution eventually may contaminate groundwater and surface water. Degradation rates of PTA were quantified in soil and soil solutions in sandy and clayey soils subjected to high natural PTA loads from bracken stands. Degradation kinetics in moist soil could be fitted with the sum of a fast and a slow first-order reaction; the fast reaction contributed 20 to 50% of the total degradation of PTA. The fast reaction was similar in all horizons, with the rate constant k1F ranging between 0.23 and 1.5/h. The slow degradation, with the rate constant k1S ranging between 0.00067 and 0.029/h, was more than twice as fast in topsoils compared to subsoils, which is attributable to higher microbial activity in topsoils. Experiments with sterile controls confirmed that nonmicrobial degradation processes constituted more than 90% of the fast degradation and 50% of the slow degradation. The lower nonmicrobial degradation rate observed in the clayey compared with the sandy soil is attributed to a stabilizing effect of PTA by clay silicates. Ptaquiloside appeared to be stable in all soil solutions, in which no degradation was observed within a period of 28 d, in strong contrast to previous studies of hydrolysis rates in artificial aqueous electrolytes. The present study predicts that the risk of PTA leaching is controlled mainly by the residence time of pore water in soil, soil microbial activity, and content of organic matter and clay silicates.
Potential for 4-n-nonylphenol biodegradation in stream sediments
Authors: Bradley Paul M , Barber Larry B , Kolpin Dana W , McMahon Peter B , Chapelle Francis H 
Published: January 2008

Abstract
The potential for in situ biodegradation of 4-nonylphenol (4-NP) was investigated in three hydrologically distinct streams impacted by wastewater treatment plants (WWTPs) in the United States. Microcosms were prepared with sediments from each site and amended with [U-ring-14C]4-n-nonylphenol (4-n-NP) as a model test substrate. Microcosms prepared with sediment collected upstream of the WWTP outfalls and incubated under oxic conditions showed rapid and complete mineralization of [U-ring-14C]4-n-NP to 14CO2 in all three systems. In contrast, no mineralization of [U-ring-14C]4-n-NP was observed in these sediments under anoxic (methanogenic) conditions. The initial linear rate of [U-ring-14C]4-n-NP mineralization in sediments from upstream and downstream of the respective WWTP outfalls was inversely correlated with the biochemical oxygen demand (BOD) of the streambed sediments. These results suggest that the net supply of dissolved oxygen to streambed sediments is a key determinant of the rate and extent of 4-NP biodegradation in stream systems. In the stream systems considered by the present study, dissolved oxygen concentrations in the overlying water column (8–10 mg/L) and in the bed sediment pore water (1–3 mg/L at a depth of 10 cm below the sediment–water interface) were consistent with active in situ 4-NP biodegradation. These results suggest WWTP procedures that maximize the delivery of dissolved oxygen while minimizing the release of BOD to stream receptors favor efficient biodegradation of 4-NP contaminants in wastewater-impacted stream environments.
Effect of the Recently Established Admissions Procedure on Success in the First-Year Exams at the University of Veterinary Medicine Vienna, Austria
Authors: Breit Sabine M , Künzel Wolfgang 
Published: January 2008

Rationale for this study—The purpose of this study was to compare the success during the first academic year of students who underwent an admissions procedure (class 2005) and students of the three previous classes (2002–2004), who did not undergo an admissions procedure but took their exams under the same curricular framework. Methodology—Exam results of 802 students of the 2002–2004 classes were compared with those of 181 students from the 2005 class. Results—Students of the 2005 class were more likely to pass all three exams given in the first academic year than students of the 2002–2004 classes (p < 0.001; OR = 3.2), and the quality of two of the three exams (indicated by individual scores) was also significantly better in 2005 than in the preceding classes (p < 0.001). In unselected classes, 25% to 31% of students showed no successful attempts to pass any of the three exams currently administered. Conclusion—The implementation of an admissions procedure measuring, among other indicators, academic ability has significantly improved first-year exam performance. Incoming students presenting with higher scores on academic standards are more likely to complete their courses successfully.