bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychological Distress Does Not Predict Decisional Regret in Patients Undergoing Spinal Reconstruction for Adult Spinal Deformity
Authors: Shen Jesse , Louie Philip , Drolet Caroline , Bansal Aiyush , Nemani Venu , Leveque Jean-Christophe , Sethi Rajiv 
Published: April 2024

Abstract

Purpose
The study aimed to assess the link between preoperative psychological distress and postoperative decisional regret in adult spinal deformity (ASD) surgery patients. We hypothesized that greater pre-surgery distress would correlate with higher post-surgery regret. This evaluation was based on a retrospective case series from an institution with standardized surgical guidelines for ASD.
Methods
This IRB-approved retrospective study analyzed our institution's ASD database from 2014 to 2020. Eligible patients had a minimum two-year post-op follow-up and preoperative psychological distress assessment. Patients were grouped based on psychological distress levels: green, yellow, and yellow minus. Regret post-surgery was assessed using the Decision Regret Scale and SRS-22 Question 22. Logistic regression evaluated the impact of distress levels on regret, controlling for age and sex.
Results
Out of 167 eligible patients, 112 responded and were analyzed. No significant demographic differences were observed between responders and non-responders. Using the Decision Regret Scale, 41% expressed no regret, while 63% expressed no regret with the SRS-22 questionnaire's Single-Item scale. Only the yellow minus group showed significant regret difference based on osteotomy, with non-recipients more likely to express regret.
Conclusion
This study found no significant link between psychological distress and post-operative regret in adult spinal deformity surgery after a minimum 2-year follow-up. Although nearly 60% exhibited some post-surgery regret, predicting regret based on psychological burden or demographics remains challenging. Further research is essential to identify factors contributing to post-operative regret in spinal deformity surgery patients.
Streamlining Pediatric Vital Sign Assessment: Innovations and Insights
Authors: Goo Seayoung , Jang Wonjin , Kim You Sun , Ji Seungbae , Park Taewoo , Park June Dong , Lee Bongjin 
Published: April 2024

Abstract

Accurate assessment of pediatric vital signs is critical for detecting abnormalities and guiding medical interventions, but establishing normal ranges is challenging due to physiological variations. Efficient tools for clinical use are necessary. Our study analyzed 1,369,608 records from the National Emergency Department Information System of Korea, focusing on patients under 15 years old admitted between January 2016 and December 2017. We developed age-specific centile curves for systolic, diastolic, and mean blood pressure, heart rate, and respiratory rate, integrating them into a web-based application at http://centile.research.or.kr. As a result of the study, a comprehensive set of centile curves was derived for systolic, diastolic, and mean blood pressure, heart rate, and respiratory rate based on age. The web application allows users to input patient data and promptly obtain centile and z-score information for vital signs, which can be an efficient tool for pediatric vital sign assessment helping early detection of abnormalities and improving patient care in various clinical settings.
A mono-coordinated gallium(I) ambiphile with redox-active and redox-inert reactivity
Authors: Kretschmer Robert , Schreiner Simon , Rüffer Tobias 
Published: April 2024

Abstract

Mono-coordinated metallyenes (R–M:) of the Group 13 elements feature a non-bonding pair of electrons together with two vacant orbitals, which makes them highly reactive ambiphiles that readily activate small molecules by oxidative addition. In consequence of their pronounced reactivity, examples of mono-coordinated organometallics of aluminium(I) and gallium(I) remain rare. Here, we report the one-step synthesis of a monomeric gallium(I) compound that readily undergoes oxidative addition reactions and, more remarkably, carbometalation reactions with alkynes by retention of the low oxidation state +I and the coordination number one at gallium. This contrasts previous reports on the reactivity of low-valent main-group compounds, which are regularly oxidized to compounds in a more stable higher oxidation state. These findings provide a new approach to access low-valent main-group compounds and pave the way for the development of novel bond-functionalisation strategies that hence could enable the development of new catalytic processes in the future.
Straight-moving tropical cyclones over the western North Pacific trigger the wave trains over the North Pacific during winter
Authors: Ma Shuaiqiong , Pang Bo , Lu Riyu , Zhou Xingyan 
Published: April 2024

Abstract

This study investigates the large-scale circulation anomalies induced by straight-moving tropical cyclones (TCs) over the western North Pacific (WNP) during winter. Corresponding to the straight-moving TCs, quasi-stationary wave trains appear as alternative geopotential height anomalies in the upper troposphere stretching from East Asia to the North Pacific. Specifically, the anomalous anticyclones are initially formed to the south of Japan and then lead to the subsequent anomalies over the Sea of Okhotsk and the Gulf of Alaska, respectively. The wave trains extend along an approximate great circle path and differ from those triggered by the recurving TCs in summer and autumn, which propagate eastward along the westerly jet. Further analysis reveals that the upper-level anticyclonic anomalies are excited by negative Rossby wave sources, which are mainly attributed to the poleward vorticity advection by anomalous divergence relevant to TCs. In addition, the diagnosis indicates that the generation of wave source is caused by the product of the TC-induced divergent flows and the prominent meridional vorticity gradient in association with East Asian upper-tropospheric westerly jet. These findings imply that the tropical disturbances over the WNP, such as straight-moving TCs, can remotely affect weather over the extratropics, and thus have implications for improving the weather forecast over the extratropics through improving tropical disturbance forecast.
Occupational pesticide exposure is linked to the prevalence of Luminal B breast cancer and poor prognosis features in Brazilian rural women
Authors: Cazagranda Isabella , de Almeida Rafaela , Smaniotto Lucca , Berny Maria Paula , Gaboardi Shaiane , Candiotto Luciano , Rech Daniel , Panis Carolina , Silveira Guilherme 
Published: April 2024

Abstract

Brazil is among the top three global consumers of pesticides, despite evidence concerning the negative impact on public health. The exposure on female rural workers has been neglected, and the incidence of pesticide-induced diseases such as breast cancer is growing. In this context, this study analyzed the impact of occupational/household pesticide exposure on the clinicopathological profile of breast cancer in rural women. Clinicopathological data were collected from medical records and analyzed from a total of 386 patients (208 exposed and 141 unexposed to pesticides). Was used descriptive and inferential statistics methods to characterize the patient data, including the chi-square test and Fisher's exact test, to evaluate associations between variables. This data was grouped as patient, tumor, and disease characteristics. Exposed patients had a prevalence of Luminal B subtype (32.83%), while unexposed patients had a prevalence of Luminal A molecular subtype (37.78%). Exposed patients also had higher disease recurrence (10.19%), chemoresistance (21.26%), and death occurrence (7.21%) than unexposed patients. Breast cancer patients exposed to pesticides were also more likely to have distant metastases and lymph node invasion compared to breast cancer unexposed patients. These findings indicate that pesticide exposure favors the occurrence of more aggressive breast cancer in rural women through occupational exposure. This results indicate that this occupational information could be added to the screening process and risk determination for breast cancer severity.
Effect of Initial Muscle Fitness on Weight Loss and Metabolically Healthy Status in Childhood Obesity: A Retrospective Study
Authors: Shang Wenya , Kong Jiaqi , Zhang Mengxue , Zhao Linlin , Wang Kun , Yang Qin 
Published: April 2024

Abstract

This study aims to investigate the effect of initial muscular fitness (MF) on weight loss and metabolically healthy status in 282 obese children under diet- and exercise-based interventions. Metabolically healthy obese (MHO) definitions established in 2018 and MF standards based on the 2021 Chinese children grip strength grading were applied. The proportion of metabolically unhealthy obese (MUO) was higher in the high MF group than their low MF counterparts at baseline. After intervention, neither group transitioned from MUO to MHO due to high frequency of low HDL-C. High MF females showed a higher percentage of high SBP than low MF females before and after intervention. High MF males exhibited greater improvements in waist circumference, hip circumference, waist-hip ratio, triglycerides, total cholesterol, and LDL-C than low MF males. The benefits of weight loss and blood lipid obtained by males are more evident than females under the same MF level. Thus, attention should be given to females during weight loss regardless of MF levels. We concluded that initial MF is not a primary factor influencing the transition from MUO to MHO status. Precision therapy should prioritize the management of blood pressure and avoid excessive reduction of HDL-C levels to sustain metabolic health.
Blinded, Randomized Tolerance Study of a Biologically Enhanced Nanogel with Endothelin-1 and Bradykinin Receptor Antagonist Peptides via Intra-Articular Injection for Osteoarthritis Treatment in Horses
Authors: Terlinden Antoinette , Jacquet Sandrine , Manivong Seng , Cullier Aurélie , Cassé Frédéric , Legendre Florence , Garcia Araceli Ac , Roullin Gaëlle , Moldovan Florina , Sirois Pierre , Banquy Xavier , Galéra Philippe , Audigié Fabrice , Demoor Magali , Bertoni Lélia 
Published: April 2024

Abstract

Background:
Osteoarthritis is a leading cause of pain and retirement in athletic horses. Hydro-expansive functionalized nanogels, acting as Drug Delivery Systems, constitute one of the current therapeutic prospects. These nanogels have the potential to combine mechanical benefits through polymers with the biological effect of prolonged release of bioactive molecules. The purpose of this double-blinded randomized tolerance study versus negative control was to evaluate the response of healthy joints to a single injection of the efficient dose and overdose of nanogels composed of chitosan and hyaluronic acid and featuring a type A endothelin receptor antagonist and a type B1 bradykinin receptor antagonist. The metacarpophalangeal joints of 8 healthy horses were randomly injected with 2.4 mL of functionalized nanogels and 2.4 mL of saline as control on the contralateral limb. Injections were repeated twice at one-week intervals, followed by injection of a triple dose of nanogel on week four. Clinical, ultrasonographic and synovial fluid cellular and biochemical follow-ups were performed up to three months following the first injection.
Results:
No change in general clinical parameters, lameness or sensitivity to passive flexion of the fetlocks was noted. Mild to moderate synovitis was noted on the day following injection in the treated group, with a significant difference (p < 0.05) compared to the control group. It spontaneously resolved on day 3 following the injections and did not increase with repeated injections. Similar effects were noted after injection of the triple dose but lasted for a week. Synovial fluid markers of inflammation also showed a transient significant increase in the treated group one week after each injection, but no differences were detected at the end of the study.
Conclusions:
Injections of the therapeutic dose of functionalized nanogel in healthy joints induced a mild transient inflammatory response in the joint. Three injections of the efficient dose at one-week intervals and injection of thrice the efficient dose induce a mildly greater inflammation without harmful effects on joints. Functionalized nanogels are well tolerated prospects for the treatment of osteoarthritis in horses. Their beneficial effects on arthritic joints have yet to be evaluated to determine their therapeutic potential.
A Calculation Method of Winding Loss of High Frequency Transformer Based on Finite Element Method
Authors: Pan Shenghua , Zhang Yuwen , Chen Huarong 
Published: April 2024

Abstract

In this paper, a winding loss calculation method used in the field of converter transformer is introduced into the field of high frequency transformer for the first time, and the influence of winding structure on the calculation accuracy of the method is considered for the first time. Taking the results of finite element simulation as the reference value, the calculation results of this method are compared with those of the formula method. The feasibility of using this method to calculate the winding loss of high frequency transformer is verified. Firstly, the winding loss of rectangular wire commonly used in small capacity high frequency transformer is analyzed. Based on the finite element simulation results, the calculation accuracy of the new method and the formula calculation method is compared to prove the feasibility of the new method. Then, using the same method, the accuracy of the new method and the formula method in calculating the winding loss of the round wire also used in the small-capacity high-frequency transformer is compared. The maximum number of continuous winding layers is changed, and the results of different layers are calculated. Finally, the cross transposition winding structure is also calculated, which proves that the new method is not only suitable for different shapes of wires, but also suitable for different winding structures. The results show that the new method has good calculation accuracy and good applicability, and can obtain more accurate calculation results of winding loss of high-frequency transformers with different shapes of windings.
Effect of Intravenous Ferric Carboxymaltose on Functional Capacity, Fatigue, and Quality of Life in Elderly Patients with Chronic Kidney Disease Not on Dialysis, Mild Anemia and Iron Deficiency. A Pilot Study
Authors: Montesa Mª Jesús Puchades , Todolí Juan Casas , Villota Julio Nuñez , Gimenez-Civera Elena , Gonzales Boris , Montomoli Marco , Espriella Rafael De la , Rico Miguel González , Torregrosa Isidro , Peña Carlos J , Cases Aleix , Górriz Jose Luis 
Published: April 2024

Abstract

Iron deficiency (ID) is highly prevalent in chronic kidney disease (CKD) and it’s associated with poorer quality of life (QoL) and functional capacity. Intravenous (IV) iron therapy is limited to CKD patients with ID and anemia to avoid/delay the need or reduce the dose of erythropoiesis-stimulating agents, according to anemia guidelines. We hypothesized that treatment with IV iron in CKD patients with ID and borderline anemia may improve their functional capacity and QoL, independently of its effects on hemoglobin. In the present study treatment with IV ferric carboximaltose was associated with a significant short-term improvement in the 6-MWT in CKD patients with ID. Patient Global Assessment, EQ-5D and Piper Fatigue Scale also improved at 4 weeks. These findings were independent of hemoglobin changes and support the role of ID per se in the worse functional capacitcy and quality of life in CKD patients.
Analysis on risk factors of hypoglycemic consciousness disorder
Authors: yan zhang , Dongmei Liu , Jia Li , Huabin Hu , Pu Huang , Yan Jun , Zhonghua Yu , Wuquan Deng , Zhian Hu , Zhongxiang Yao , Debin Lu 
Published: April 2024

Abstract

Backgroud : Hypoglycemia can easily cause consciousness disorder, but some patients may not experience it. Currently, few clinical studies have delved into the characteristics of hypoglycemic patients, as well as the inducers and risk factors of consciousness disorder.
Objective : To explore the high-risk factors and inducements of consciousness disorder in patients with hypoglycemia.
Methods : Totally 292 inpatients were selected who received hypoglycemia treatment in the Fifth People's Hospital of Chongqing, Chongqing Emergency Medical Center, and Yubei People's Hospital from January 2010 to June 2022. The patients were divided into consciousness disorder group (n=220) and non-consciousness disorder group (n=72) according to the consciousness disorder at admission. We compared proportion of diabetic patients, blood glucose level, duration of hypoglycemia, and incidence rate of complications between two groups, and analyzed the predisposing factors of hypoglycemic consciousness disorders and the outcomes after treatment of hypoglycemia.
Results : All 292 patients were mainly elderly (87.67%) and diabetic (80.14%). Among these, 220 cases (66.7%) were complicated with consciousness disorder. Insulin injection and infection were the major inducements of hypoglycemic consciousness disorder. Compared with non-consciousness disorder group, the disorder group had lower blood glucose levels and longer hypoglycemia durations. Fewer patients had diabetes and hypertension alone , those with multiple comorbidities were more prevalent .Besides ,there was no significant difference in age, sex and serum creatinine level between two groups.
Conclusion : The main inducements of hypoglycemic consciousness disorder are insulin injection and infection, And the high-risk factors include severity and duration of hypoglycemia , as well as various complications, but the patients with diabetes and hypertension alone are relatively less likely to develop consciousness disorder during hypoglycemia.
The Impact of Intraoperative Hypotension on Postoperative Acute Kidney Injury, Mortality and Length of Stay following Off-Pump Coronary Artery Bypass Grafting Surgery: a single-center retrospective cohort study
Authors: xiao cheng , yang ming , cao lei , chen fang , jing sheng , tan yuting , li hong 
Published: April 2024

Abstract
Background Off-pump coronary artery bypass grafting (OPCABG) presents distinct hemodynamic characteristics, yet the relationship between intraoperative hypotension and short-term adverse outcomes remains clear. Our study aims to investigate association between intraoperative hypotension and postoperative acute kidney injury (AKI), mortality and length of stay in OPCABG patients.
Methods Retrospective data of 494 patients underwent OPCABG from January 2016 to July 2023 were collected. We analyzed the relationship between intraoperative various hypotension absolute values (MAP >75, 65< MAP ≤ 75, 55< MAP ≤65, MAP ≤55 mmHg) and postoperative AKI, mortality and length of stay. Logistic regression assessed the impacts of exposure variable on AKI and postoperative mortality. Linear regression was used to analyze risk factors on the length of intensive care unit stay (ICU) and hospital stay.
Results The incidence of AKI was 31.8 %, with in-hospital and 30-day mortality at 2.8 % and 3.5 %, respectively. Maintaining a MAP greater than or equal 65 mmHg [odds ratio (OR) 0.408; p=0.008] and 75 mmHg (OR 0.479; p=0.024) was significantly associated with a decrease risk of AKI compared to MAP less than 55 mmHg for at least 10 minutes. Prolonged hospital stays were linked to low MAP, while in-hospital mortality and 30-day mortality were not linked to IOH but exhibited correlation with a history of myocardial infarction. AKI showed correlation with length of ICU stay.
Conclusions MAP > 65 mmHg emerges as a significant independent protective
factor for AKI in OPCABG and IOH is related to length of hospital stay. Proactive intervention targeting intraoperative hypotension may provide a potential opportunity to reduce postoperative renal injury and hospital stay.
Trial registration ChiCTR2400082518. Registered 31 March 2024. https://www.chictr.org.cn/bin/project/edit?pid=225349
Exploring the relationship between dental anxiety and blood pressure in urgent dental care patients: an observational study
Authors: Pallos Debora , Miziara Luciano , Cavalcante Larissa , Rocha Najila , Pereira Jose Eduardo , Martins Fabiana 
Published: April 2024

Abstract

Background: Dental anxiety is frequently observed in dental clinics, and when an increase in blood pressure (BP) values is detected, it can be classified as a type of white coat hypertension (WCH). The goal of this study was to monitor blood pressure before and after emergency dental treatments in a university dental clinic and to discuss the importance of approaching these patients considering their BP values and dental anxiety.
Methods: This cross-sectional observational research randomly included patients in the dental waiting room of an urgent care clinic. A mercury sphygmomanometer was used by two calibrated researchers to assess the study participants before (T1) and after (T2) the emergency dental consultation. The variation in BP measurement was statistically compared with the Visual Analogue Scale (VAS), dental history, high blood pressure (HBP), and other comorbidities.
Results: Among all participants (n = 75), the mean age was 45.5 ± 12.7 years old, 66.7% of patients were female, 78.7% had pain before dental care, VAS scale (5.2 ± 3.5), and used painkillers, and 44.4% reported dental anxiety. HBP was detected in 60% of patients (>130 mmHg), 53.3% of patients had a family history of HBP, 28.9% were diagnosed with AH, and among these, 50% were regularly using antihypertensive medication. The average systolic BP (SBP) was 131.9 and the diastolic BP (DBP) was 90.4 mm/hg, and in terms of evolution, the variation was 3.7 to 1.7, respectively.
Conclusions: This study showed that BP monitoring at the dental clinic is recommended, and most patients presented HBP before the consultation, but these parameters were not considered decisive for canceling the dental urgent care.
Experience and advice consequences shape information sharing strategies
Authors: Anllo Hernan , Salamander Gil , Palminteri Stefano , Raihani Nichola , Hertz Uri 
Published: April 2024

Abstract

Individuals often rely on the advice of more experienced peers to minimize uncertainty and increase success likelihood. In most domains where knowledge is acquired through experience, advisers are themselves continuously learning. Here we examine the way advising behavior changes throughout the learning process, and the way that costs and benefits of giving advice shape this behavior. We ran a series of experiments implementing a decision task within a reinforcement learning framework, where participants could decide to share their choices as advice to others. Participants were overall likely to share their choices as advice, even on the first trial before learning. Tendency to share advice and advice quality increased as advisers learned about the value of choices, and moved from exploratory to exploitative behavior. The introduction of consequences to advising resulted in a shift of the overall tendency to give advice, lowering it when advising implicated monetary loss, and increasing it when advising held reputational value. Individual differences in social anxiety levels were associated with lower tendency to share exploratory decisions. Our results show that advisers tend to share choices that are backed by their own experience, but that this relationship can be altered by advice-consequences and individual traits.