bluuebunny/crossref_metadata_2025_split huggingface dataset:
Malignant melanoma of the perineum
Authors: Johnson Amy , Mathai George , Robinson William A. 
Published: February 2007

AbstractWe conducted a retrospective review of the medical records of 18 patients diagnosed at the University of Colorado with perineal melanoma. Clinical characteristics including Clark's level, recurrence, and survival were studied. Ten patients (55.6%) had vulvar melanoma, 2 patients (11.1%) had vaginal disease, and the remaining 6 patients (33.3%) had primary rectal melanoma. All patients were treated surgically at the time of diagnosis. At a median follow‐up of 32.7 months, 15 patients had evidence of recurrence. Nine of these patients are dead and six are alive with disease. The average time to recurrence was 14 months and the most common site was the regional lymph nodes in 10 of the 14 patients (71.4%). This study confirms the poor prognosis in perineal melanoma and the only effective treatment to date is early diagnosis and complete resection. © 1993 Wiley‐Liss, Inc.
Carotid body tumors
Authors: Sanghvi Vikram D. , Chandawarkar Rajiv Y. 
Published: February 2007

AbstractA retrospective study of 20 patients treated at the Tata Memorial Hospital over a period of 50 years, 1941–1991, is presented. Seventy‐five percent (15/20) of the patients presented before their fifth decade with a male‐to‐female ratio of 2:1. The commonest presenting symptom was a painless lump in the neck. Twenty‐five percent (5/20) had an incisional biopsy done elsewhere prior to referral to our institute. We performed a subadventitial excision of the tumor in 17 patients, 3 of whom were given postoperative radiation therapy. Three patients underwent complete excision of the carotid system without a vascular replacement, one of whom developed hemiparesis secondary to a cerebral infarct. There was no operative/ postoperative mortality. Cranial nerve palsy was seen in 45% (9/20) of patients; the hypoglossal nerve was most commonly affected. One patient had a recurrence, 6 years after surgery, whereas 60% of patients operated on before 1987 have completed a 5‐year disease free survival. Forty percent of patients have yet to have a 5‐year follow‐up period. Reports of newer diagnostic and therapeutic modalities are discussed. © 1993 Wiley‐Liss, Inc.
Pancreatic ductal cell carcinoma producing pancreatic elastase 1
Authors: Iwase Kazuhiro , Miyata Masahiko , Yamaguchi Tokio , Kawaguchi Takanobu , Tanaka Yasuhiro , Matsuda Hikaru 
Published: February 2007

AbstractThe elevation of plasma pancreatic elastase 1 in patients with pancreatic cancer is caused by concomitant pancreatitis. There is no report that pancreatic ductal cell carcinoma tissue itself produced elastase 1. A 54‐year‐old woman underwent total pancreatectomy for pancreatic ductal cell carcinoma. Her plasma elastase 1 level subsequently decreased from the preoperative value of 406 ng/dl to values ranging between 96 ng/dl and 119 ng/dl, until 6 months after the operation, when it began to increase gradually to a maximum of 300 ng/dl in association with local recurrence and hepatic metastasis. Immunohistochemical staining of elastase 1 was positive in the primary tumor resected at operation as well as in the locally recurrent and hepatic metastatic tumors obtained at autopsy. These findings suggested that elastase 1 was produced by the tumor cells in this patient. This is the first case in which pancreatic ductal cell carcinoma cells produced elastase 1. © 1993 Wiley‐Liss, Inc.
Enteroenteric intussusception due to a metastatic malignant fibrous histiocytoma
Authors: Gorman Robert C. , Jardines Lori , Brooks John J. , Daly John M. 
Published: February 2007

AbstractIntussusception secondary to metastatic sarcoma is an unusual cause of small bowel obstruction. When a patient who has no history of a previous laparotomy, and has a known malignancy which metastasized hematoge‐nously, presents with small bowel obstruction, the diagnosis of intussusception should be considered. The patient should be evaluated and treated accordingly. © 1993 Wiley‐Liss, Inc.
Growth inhibition of human gastrointestinal cancer xenograft lines by treatment with CPT‐11 and VP‐16
Authors: Nagai Satoshi , Yamauchi Masaji , Satta Tetsuya , Kodera Yasuhiro , Kondou Ken , Akiyaya Seiji , Ito Katsuki , Takagi Hiroshi 
Published: February 2007

AbstractA water‐soluble and stable camptothecin derivative, CPT‐11, was found to possess a strong antitumor activity against various murine tumors. In the present study, CPT‐11 was tested against ten human gastrointestinal cancer xenograft lines carried by nude mice. CPT‐11 was very effective against nine xenograft lines, with the exception of one xenograft. On the other hand, VP‐16 was ineffective against all these xenograft lines. Therefore, CPT‐11 is expected to be clinically more effective against gastrointestinal cancer than the topo II targeting agent. © 1993 Wiley‐Liss, Inc.
Thyroid nodules in female uremic patients on maintenance hemodialysis
Authors: Miki Hitoshi , Oshimo Kazushi , Inoue Hiroyuki , Kawano Muneo , Tanaka Katsuhiro , Komaki Kansei , Uyama Tadashi , Kawauchi Mamoru , Minakuchi Jun , Kawashima Syu , Monden Yasumasa 
Published: February 2007

AbstractWe investigated the incidence of thyroid nodules in female uremic patients on maintenance hemodialysis using a high‐frequency sonographic scanner. In 47 (21.0%) of the 224 female normal controls and 33 (55.0%) of the 60 female patients, thyroid nodules were detected. The difference in these incidences between controls and patients was significant. There were no differences in age, duration of hemodialysis, the level of blood urea nitrogen, parathyroid hormone or thyroid stimulating hormone between the patients with thyroid nodules and those without nodules. Although there is a correlation between uremia and the development of thyroid nodules, the details of the underlying mechanism of their association remain unclear. © 1993 Wiley‐Liss, Inc.
Tracheal tear during laryngopharyngectomy with gastric transposition
Authors: Deshmane Vinay H. , Divatia Jigeeshu V. , Dasgupta Dipankar , Hodarkar Shubha R. , Parikh Hemen K. , Parikh Deepak M. , Shah Sushila C. , Rao Raja S. 
Published: February 2007

AbstractTracheal rutpure occurred in 7 of 174 (4%) patients undergoing laryngopharyngectomy with gastric transposition. Tracheal tears were classified as proximal if they involved the upper two‐thirds of the trachea (five patients), or distal if they extended into the lower one‐third of the trachea (two patients) and their clinical features and management analyzed. Predisposing factors, including prior radiotherapy (three patients) and preoperative tracheostomy (1 patient) did not influence the site or severity of tracheal injury. Proximal tears were detected incidentally in four patients, but in one patient, manifested postoperatively with subcutaneous emphysema and pneumothorax. Distal tears manifested dramatically with a ventilatory leak. Adequate access for repair of distal tears may necessitate a right thoracotomy while proximal tears may be sutured through the cervical incision. Gastric transposition alone did not prevent air leak in two patients. Postoperative complications included prolapse of the stomach and bilateral pneumothoraces in one patient. Close interaction between the surgeon and the anesthesiologist ensured a successful outcome in six patients. There was one mortality. © 1993 Wiley‐Liss, Inc.
Response with combined modality treatment in childhood rhabdomyosarcoma
Authors: Raje Noopur S. , Rao Suchitra R. , Vaidya Sucheta J. , Shah Rajesh V. , Nair Chandrika N. , Pai Suresh K. , Kurkure Purna A. , Pande Subodhchandra C. , Desai Prafulla B. , Advani Suresh H. 
Published: February 2007

AbstractChildren diagnosed with rhabdomyosarcoma at the Tata Memorial Hospital during the period January 1986‐December 1988 were studied. All were treated with combination chemotherapy incorporating vincristine, Adriamycin, and cyclophosphamide given sequentially in repeated cycles over 18 months, along with local radiotherapy. Of 24 patients, 18 patients had advanced‐stage disease at onset. All patients have been followed up for 18 months or more. Of the 11 patients with group III disease, six are in complete remission; of the six patients with group IV disease, two patients are in complete remission. These results are clearly better than those achieved in the past, where surgery was employed as the primary modality of therapy with chemoradiotherapy given only for patients with group IV disease. © 1993 Wiley‐Liss, Inc.
Psychologic and cosmetic self‐assessments of breast conserving therapy compared with mastectomy and immediate breast reconstruction
Authors: Noguchi Masakuni , Kitagawa Hirohisa , Kinoshita Kazuo , Earashi M. , Miyazaki Itsuo , Tatsukuchi Sadako , Saito Yasuo , Mizukami Yuji , Nonomura Akira , Nakamura Shinobu , Michigishi Takatoshi 
Published: February 2007

AbstractCosmetic and psychologic morbidity was evaluated by patients self‐assessment in 42 patients who underwent breast conserving therapy (BCT) and 48 patients who underwent mastectomy with immediate breast reconstruction (MIBR). Although sexual adjustment and fear of cancer recurrence were not significantly different between the two groups, body image was rated as significantly better in the BCT group. Additionally, in the MIBR group, nine patients expressed concern about abdominal or back scars and 15 related abdominal or back pain. Eighty‐three percent of the BCT group indicated BCT as a future choice of treatment, whereas only 38% of the MIBR group indicated MIBR as a future choice of treatment. Therefore, body image and patients' satisfaction were thought to have been improved by BCT, but psychologic morbidity was the same in both groups. © 1993 Wiley‐Liss, Inc.
Nephrectomy for metastatic renal cell carcinoma: A component of systemic treatment regimens
Authors: Wolf J. Stuart , Aronson Frederick R. , Small Eric J. , Carroll Peter R. 
Published: February 2007

AbstractNew immunotherapeutic and chemotherapeutic regimens have altered the medical approach to metastatic renal cell carcinoma (RCC). Surgery for metastatic RCC needs to be reappraised in the context of these developments. We retrospectively examined the course of 25 patients with metastatic RCC who underwent nephrectomy or resection of renal fossa recurrences as an adjunct to intended systemic therapy. Four patients (16%) had complications and there was no perioperative mortality. Of 23 patients who had surgery first, 17 received subsequent systemic therapy and 2 experienced a response. Two patients underwent nephrectomy after achieving a partial response with systemic therapy. Overall, 3 patients (12%) are alive without detectable disease, 8 (32%) are alive with disease, and 14 (56%) are dead of disease, with a median survival of 23.5 months. Nephrectomy for metastatic renal cell carcinoma may be associated with less morbidity and mortality than previously reported. When initial nephrectomy is performed, most patients go on to receive systemic therapy. Within the context of a systemic treatment regimen, nephrectomy continues to play a role in the management of selected patients with metastatic RCC. © Wiley‐Liss, Inc.
Morbidity of radical retropubic prostatectomy following previous prostate resection
Authors: Ramon Jacob , Rossignol Georges , Leandri Pierre , Gautier Jean Romain , Wajsman Zev 
Published: February 2007

AbstractA total of 153 patients with prior prostate surgery underwent a radical retropubic prostatectomy for carcinoma of the prostate. Ninety‐seven patients had undergone transurethral resection of the prostate (TURP), and 56 patients had undergone suprapubic transvesical prostatectomy (SPP). In 115 patients, the diagnosis of malignancy was made at the time of transurethral resection or enucleation. No perioperative deaths occurred and no patient suffered rectal injury or ureteral transection. Operative time and blood loss were similar between the TURP and SPP groups and were not different in a group of patients who had not had prior prostate surgery. Early and late complications occurred in eight patients (5.2%), of whom seven had had previous TURP. Complete urinary control was achieved in 96% (147) of the patients; stress incontinence was present in 4% (6 patients); and no patient was totally incontinent. Postoperative complications and the occurrence of stress incontinence were not related to the time elapsed between the previous prostate surgery and the radical prostatectomy. Sexual function was preserved in 32 (71%) of the 45 patients in whom we performed a nerve‐sparing radical prostatectomy. Residual cancer was found in the radical prostatectomy specimen in 77 (67%) of the stage A patients. Twenty‐nine (25%) of the stage A and 13 (34%) of the stage B patients had pathological evidence of disease extension beyond the confined prostate. Follow‐up was 6–92 months, with a mean of 32 months. Four patients died of prostatic cancer, two patients died without cancer, and five have evidence of disease progression; 142 (93%) are alive without evidence of disease. Although radical prostatectomy sometimes is more difficult after previous prostate surgery, operative complication rates, patient morbidity, and the opportunity for surgical cure are not different from those seen in patients with no history of previous prostate Operations. © Wiley‐Liss, Inc.
Survival differences between black and white women with breast cancer
Authors: Elias E. George , Suter Charles M. , Brown Sally D. , Buda Barbara S. , Vachon Debra A. 
Published: February 2007

AbstractSeveral reports have indicated that black women with breast cancer have a poorer prognosis than white women. To investigate this phenomenon and to identify some of the underlying reasons, 172 patients with infiltrating ductal carcinoma of the breast, who were managed similarly, were studied. Survival analysis comparing the two populations with breast cancer revealed that white women had significantly longer overall survival (OS), P = 0.015 by Wilcoxon and 0.019 by log‐rank, and borderline significantly longer disease‐free survival (DFS), P = 0.04 by Wilcoxon and 0.07 by log‐rank. While there was no significant difference in OS and DFS between the two groups with negative nodes, significantly poorer DFS and OS was noted in black patients with one to three positive lymph nodes compared to white patients, P = 0.008. The white patients had a higher incidence of hormone receptor‐positive tumors, especially progesterone receptor (P = 0.0016). However, survival analysis failed to show any difference between the black and the white populations based on hormonal receptors. Such findings suggested that further investigation of other factor(s) is warranted. © Wiley‐Liss, Inc.
Selective digital enhancement of conventional film mammography
Authors: Hale Maj. Douglas A. , Cook Jay F. , Baniqued Zita , Silva‐Hale Antonia , Molloy Mark , Pearl Richard H. , Hadro Neal C. , Jaques David P. 
Published: February 2007

AbstractScreening mammography continues to play a key role in the early diagnosis of non‐palpable breast cancer. Approximately 5% of patients will have lesions on their mammograms that appear neither clearly benign nor malignant. The proper management of these patients is not well defined. In this study, the mammograms of 64 women who underwent breast biopsy were reviewed. After the initial review, the mammograms were reevaluated using a personal computer driven digital conversion and enhancement system. The majority of indeterminate lesions were assigned a determinate diagnosis by enhancing the areas of abnormality through enlargement, contrast adjustment, and brightness adjustment. The radiologists were able to maintain baseline sensitivity and specificity throughout this process. In contrast, enhancement of lesions initially assigned a diagnosis of characteristically benign or malignant demonstrated no advantage over plain film mammography. These findings suggest a role for the selective use of digital mammography and enhancement techniques. © Wiley‐Liss, Inc.
Mediastinal tracheostomy during esophagectomy for cervicothoracic esophageal carcinoma invading the proximal trachea
Authors: Kato Hoichi , Tachimori Yuji , Watanabe Hiroshi , Nakatsuka Takashi , Mashima Kazuhiko , Ebihara Satoshi , Harii Kiyonori 
Published: February 2007

AbstractA total of 16 patients with carcinoma in the cervicothoracic esophagus underwent pharyngolaryngoesophagectomy with construction of a mediastinal tracheostoma. Among them, seven patients underwent transhiatal esophagectomy without thoracotomy, four proximal esophagectomy by cervicotomy and sternal split, and five cervical and thoracic esophagectomy and lymphadenectomy by cervicotomy and right thoracotomy. Free jejunal transfer was performed to reconstruct the esophagus in five patients, and the stomachs were used in ten. One patient died of pneumonia 27 days after surgery, and two of arterial blowout. Plastic and reconstructive surgery techniques were introduced to protect large vessels and cover the wound. The postoperative 30‐day mortality was 6.3% and the total operative mortality was 18.8%. Median survival was 327 days. Mediastinal tracheostomy is safely applicable today for patients with esophageal carcinoma invading the proximal trachea, allowing them to achieve safe respiration and to enjoy meals. © Wiley‐Liss, Inc.
Production of cytokines by thyroid carcinoma cell lines
Authors: Yoshida Akira , Asaga Tarou , Masuzawa Chihiro , Kawahara Satoru , Yanoma Shunsuke , Harada Masaoki , Okamoto Takasi 
Published: February 2007

AbstractFive cell lines were established from four undifferentiated carcinomas and one squamous cell carcinoma of the thyroid. The levels of several kinds of cytokines were measured in the conditioned media of these cell lines by enzyme‐linked immunosorbent assay (ELISA). Interleukin‐6 (IL‐6) was produced by four of the five cell lines, interleukin‐1α (IL‐lα) by three cell lines, and granulocyte‐colony stimulating factor (G‐CSF) by two cell lines. The mRNA of IL‐lα or IL‐6 was detected by Northern blot analysis in all the cell lines which secreted these cytokines into culture medium. These results suggest that undifferentiated carcinoma and squamous cell carcinoma of the thyroid frequently produce cytokines. Further studies are needed to clarify the possible clinical effects of these cytokines in patients with thyroid carcinoma. © Wiley‐Liss, Inc.
S100 protein positive human breast carcinomas: An immunohistochemical study
Authors: Matsushima Shoko , Mori Masaki , Adachi Yosuke , Matsukuma Akito , Sugimachi Keizo 
Published: February 2007

AbstractAn immunohistochemical study for S100 protein was performed on 95 human breast carcinomas. S100 protein positive carcinoma cells were recognized in 54 cases (57%). The S100 protein positive and negative carcinomas were then compared in terms of stage, histologic type, nuclear grade, appearance of minute calcification, immunoreactivity for estrogen receptor (ER), tumor recurrent pattern, and prognosis. The S100 protein positive cases had a tendency to show a low nuclear grade (P < 0.01). They were also more often seen in the ER positive group. For further analysis of the nature of S100 protein positive carcinoma cells, immunoreactivity for neuron‐specific enolase (NSE) and actin was investigated. The positive staining for NSE and actin was seen in 46 cases (48%) and 3 cases (3%), respectively. There was, however, no specific correlation among the S100 protein, NSE, or actin staining. The nature of S100 protein positive carcinoma cells still remains unclear. The S100 protein positive carcinomas, however, exhibit relatively better characteristics. © Wiley‐Liss, Inc.
Influence of portal branch ligation on the outcome of repeat dearterializations of an experimental liver tumor in the rat
Authors: Wang Li‐Qing , Persson Bo G. , Stenram Unne , Bengmark Stig 
Published: February 2007

AbstractIt has been suggested that the portal vein should be occluded during intermittent hepatic dearterialization in order to induce a more complete ischemia of the tumor. In this experiment the influence of portal branch ligation in combination with repeat dearterializations on a liver tumor was investigated. Twenty‐seven rats were randomly allocated to sham treatment (n = 6); portal branch ligation (PBL) (n = 7); 120 min of repeat dearterialization (n = 7); and portal branch ligation (PBL) in combination with 50 min of repeat dearterialization (n = 7) (once a day during 5 days). The results showed that portal branch ligation alone did not alter the tumor growth compared with sham treatment (P > 0.05), nor did portal branch ligation in combination with repeat dearterializations for 50 min (P > 0.05). However, tumor growth delay was achieved following 120 min of repeat dearterializations without occlusion of the portal branch (P < 0.01 versus all the other groups). There was a significant weight loss of the lobe undergoing PBL, whether dearterialization was added or not (P < 0.001). The liver nucleotide/DNA and RNA/DNA ratio significantly decreased as well. Histological examination showed that > 50% of tumor cells became necrotic after repeat dearterializations for 2 hr indicating a significant damage to tumor tissue. In contrast, PBL in combination with repeat dearterializations for 50 min induced extensive liver necrosis without having any influence on tumor growth. © Wiley‐Liss, Inc.
Endometrioid adenocarcinoma of the prostate: A clinicopathologic and immunohistochemical study
Authors: Lee Shiong S. 
Published: February 2007

AbstractOn retrospective review of the tumor registry files between 1979 and 1992 at the North Iowa Medical Center, six cases of endometrioid adenocarcinoma of the prostate were identified among 1582 cases of prostatic carcinoma. Along with long‐term clinicopathologic follow‐up, immunohistochemical studies of the prostatic tumor tissues were performed. All six cases of endometrioid carcinoma, together with control cases of benign prostatic hypertrophy (BPH) and ordinary adenocarcinoma of the prostate had unequivocal diffuse positive staining for PSA and similar reactivity to ER‐D5 and PS2. Thus, endometrioid carcinoma is most likely derived from the prostate or prostatic urethral duct rather than the utricle. However, due to its unusual initial clinical manifestations, biological behavior, and distinctive histomorphology, the term “endometrioid adenocarcinoma of the prostate” is worth preserving. © Wiley‐Liss, Inc.