bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lack of Pathologic Q Waves: A Specific Marker of Viability in Myocardial Hibernation
Authors: Jeon Hui‐Kyung , Shah Gopi A. , Diwan Abhinav , Cwajg Jucylea M. , Park Tae‐Ho , McCulloch Marti L. , Zoghbi William A. 
Published: August 2008

AbstractBackgroundThe present study evaluates the lack of Q waves on the electrocardiogram (ECG) in the prediction of myocardial viability compared with dobutamine stress echocardiography (DSE) and rest‐redistribution thallium‐201 (Tl‐201) scintigraphy.HypothesisThe lack of pathologic Q waves (NoQ) may be a readily available and specific marker for the presence of viability.MethodsSixty four patients with stable coronary artery disease (CAD) and ventricular dysfunction underwent rest ECG, DSE, and Tl‐201 scintigraphy before revascularization, and a repeat rest 2‐Dimensional (2‐D) echocardiogram more than 3 mo later.ResultsTotal viability at baseline (% of total segments) was higher in the NoQ group by Tl‐201 scintigraphy (87 ± 19% versus 70 ± 20%, p = 0.008) and by DSE (81 ± 20% versus 65 ± 24%, p = 0.013). As expected, the sensitivity of NoQ waves was low in predicting recovery of function (23%), and inferior to Tl‐201 (82%) and DSE (84%) (p<0.08). However, specificity of NoQ waves for predicting recovery of global function was high (72%); higher than Tl‐201 (50%) and DSE (45%). Positive predictive values were comparable among all modalities. Results were similar if the data were analyzed regionally for viability.ConclusionLack of pathologic Q waves is a specific and readily available marker of myocardial viability in patients with chronic CAD, which should alert the clinician for myocardial hibernation. Copyright © 2008 Wiley Periodicals, Inc.
Diagnosing Left Ventricular Noncompaction by Echocardiography and Cardiac Magnetic Resonance Imaging and Its Dependency on Neuromuscular Disorders
Authors: Stöllberger Claudia , Kopsa Wolfgang , Tscherney Robert , Finsterer Josef 
Published: August 2008

AbstractBackgroundLeft ventricular hypertrabeculation (LVHT), also termed noncompaction LVHT, is diagnosed by echocardiography or cardiac magnetic resonance imaging (CMRI), and associated with neuromuscular disorders (NMD). The aim of this study was to assess if LVHT can be diagnosed by CMRI applying echocardiographic definitions.Methods and ResultsThe CMRI images of 19 echocardiographically diagnosed LVHT patients were re‐evaluated (10 female, 14‐67 y of age). Left ventricular hypertrabeculation was diagnosed by CMRI in 9 cases. Patients with CMRI‐diagnosed LVHT were more often females (67% versus 40%), experienced heart failure more often (100% versus 50%), had an LV end diastolic diameter > 57 mm (67% versus 40%), had an LV fractional shortening < 25% (89% versus 40%), and had a larger extension of LVHT than patients without CMRI‐diagnosed LVHT. The prevalence of NMD (87%) did not differ between both groups.ConclusionsEchocardiographic definition for CMRI yielded the diagnosis of LVHT in only 47%. When looking for LVHT by CMRI, LV size, function, and extension of LVHT have to be considered. Copyright © 2008 Wiley Periodicals, Inc.
Epidemiology of Heart Failure in a Tertiary Pediatric Center
Authors: Massin Martial M. , Astadicko Iyawa , Dessy Hugues 
Published: August 2008

AbstractBackgroundIn contrast to the adult age group, epidemiologic studies on heart failure (HF) in the pediatric population are lacking. The aim of this prospective study was to analyze the epidemiology of HF during infancy and childhood.MethodsOf the 1,196 children with congenital and acquired heart diseases, primarily diagnosed during a 10‐y period in one hospital, we identified those patients who developed HF.ResultsWithin 10 y, 1,196 children with heart disease were indexed. Heart failure occurred in 124 of these patients (10.4%): 64 out of 1,031 children with congenital heart diseases (6.2%), 13 out of 96 children with rhythm or conduction disturbances (13.5%), 23 out of 39 children with acquired heart diseases (59.0%), and 24 out of 30 children with cardiomyopathies (80.0%). Heart failure occurred in 72 cases (58.1%) during the first year of life. The incidence in infancy was much more pronounced for congenital heart diseases than for other cardiac conditions. The mortality associated with HF and its cause was also lower for children with congenital heart disease (4.7%) than for the other cardiac conditions (8.7%, 23.0%, and 25.0%, for acquired heart diseases, rhythm disturbances, and cardiomyopathies, respectively).ConclusionClear differences exist between HF in infants and HF in children. Our study supports the observation that congenital heart disease is the most common causative factor of HF during infancy. Older children with HF are more likely to have acquired heart diseases, cardiomyopathies, and arrhythmias, and these conditions have a considerable mortality. Copyright © 2008 Wiley Periodicals, Inc.
Alcohol, Wine, and Cardiovascular Health
Authors: Lindberg Matthew L. , Amsterdam Ezra A. 
Published: August 2008

AbstractStudies evaluating the health benefits of alcohol and wine have demonstrated that moderate consumption is associated with a decrease in all‐cause and cardiovascular mortality. Various populations and alcoholic beverages exhibit this effect to different degrees. Alcoholic beverages exhibit multiple mechanisms that may favorably influence cardiac risk potential actions on platelets, antioxidants, fibrinolysis, and lipids. However, other data suggest that the perceived benefit of alcoholic beverages in general, and wine in particular, are the result of socioeconomic confounders. In the absence of more rigorous evidence, it is not currently possible to define the role of wine in human health. Copyright © 2008 Wiley Periodicals, Inc.
Assessment of Regional Systolic and Diastolic Functions Affected by Atorvastatin in Coronary Artery Disease Using Tissue Doppler Imaging
Authors: Qie Liangyi , Meng Xiao , Wang Yubin , Feng Min , Zhong Ming , Li Li 
Published: August 2008

AbstractBackgroundSeveral studies have shown regional left ventricular (LV) systolic and diastolic changes associated with coronary artery disease (CAD). Statins may have beneficial pleiotropic effects in addition to their lipid‐lowering properties.HypothesisWe hypothesized that atorvastatin can improve regional LV systolic and diastolic functions in CAD patients using tissue Doppler imaging (TDI).MethodsA total of 63 patients with hyperlipemia and CAD were studied. Forty‐three patients were given 10 mg daily of atorvastatin and 20 patients were assigned only a low‐fat diet. Tissue Doppler imaging was applied to evaluate LV peak systolic velocity (VS), early diastolic velocity (VE), and late diastolic velocity (VA) in 18 segments. The mean value of LV peak systolic velocity (VS′), the mean value of early diastolic velocity (VE′), and the mean value of late diastolic velocity (VA′), in 18 segments were calculated.ResultsCompared with the baseline, VS′, and VE′, increased significantly after the therapy in the atorvastatin group (p < 0.05), while there was no change in the control group (p > 0.05). At 6 mo of therapy, a significant reduction in total cholesterol, triglyceride, and low‐density lipoprotein (LDL) cholesterol was observed in the 2 groups (p < 0.05).ConclusionsThese findings demonstrate that atorvastatin can improve regional LV systolic and diastolic functions in CAD patients independent of its lipid‐lowering properties. Copyright © 2008 Wiley Periodicals, Inc.
Carbon‐coated Stents in Patients with Acute Coronary Syndromes
Authors: Wöhrle Jochen , Nusser Thorsten , Langenwalder Simone , Heombach Vinzenz , Kochs Matthias 
Published: August 2008

AbstractBackgroundFor patients with ST elevation myocardial infarction (STEMI) or non‐ST elevation myocardial infarction (NSTEMI), rapid restoration of coronary blood flow is the primary therapeutic goal. Because of the acute nature of this clinical presentation, bleeding risks may not be adequately evaluated, limiting the use of drug‐eluting stents, since premature discontinuation of antiplatelet therapy strongly predicts stent thrombosis. We evaluated angiographic and clinical results of non‐drug‐eluting carbon‐coated stents.MethodsIn this prospective observational study, angiographic and clinical 6‐mo results of a carbon‐coated stent for treatment of acute lesions in native coronary arteries were evaluated. Angiographic main outcome measures included in‐stent late loss and binary restenosis rate. Major adverse cardiac events (MACEs) were defined as any death, Q‐wave myocardial infarction (MI), and target lesion revascularization.ResultsWe included 320 patients with STEMI (n = 205) or NSTEMI (n = 115) with 360 lesions. Reference vessel diameter was 2.93 ± 0.53 mm and stented length 22.7 ± 13.8 mm. Angiographic follow‐up was available in 220 of 360 lesions (61%). In‐stent late loss was 0.69 ± 0.75 mm, with a binary restenosis rate of 19.1%. For the total segment late loss was 0.74 ± 0.77 mm and binary restenosis rate 21.4%. Clinical follow‐up for 97.4% of discharged patients was available. Hierarchical MACEs were death in 14 patients (4.4%), Q‐wave MI in 3 patients (0.9%), and target lesion revascularization in 39 patients (12.2%).ConclusionIn this prospective, observational study, the use of a carbon‐coated stent for treatment of lesions in patients with STEMI or NSTEMI was associated with a low late loss, translating into a low binary angiographic restenosis rate within a 6‐mo follow‐up. Copyright © 2008 Wiley Periodicals, Inc.
Association Between Fibromyalgia and Coronary Heart Disease and Coronary Catheterization
Authors: Ablin Jacob N. , Beilinson Natella , Aloush Valerie , Elkayam Ori , Finkelstein Ariel 
Published: August 2008

AbstractBackgroundFibromyalgia (FM) has been associated with physical and emotional trauma including invasive medical procedures. Both FM and ischemic heart disease have been linked with depression. The purpose of this study was to retrospectively investigate the frequency of FM symptoms and physical findings among patients undergoing coronary catheterization.MethodsConsecutive patients who underwent coronary angiography during the previous 6 mo were recruited. Patients with major depression, bi‐polar disorder, schizophrenia, or malignancy were excluded. Patients underwent dolorimetry for tender‐point assessment and completed the fibromyalgia impact questionnaire (FIQ). Group A included patients with significant coronary pathology (n = 43), group B included patients with normal coronary arteries (n = 50), and group C included patients with normal controls (n = 51). A cardiological score incorporated the number of coronary arteries with significant pathology and left ventricular function. Chi‐square or Fisher's exact test was used for categorical data and a one‐way analysis of variance for continuous variables; a multivariate linear regression was performed to compare groups.ResultsSignificantly increased levels of tenderness were discovered among patients with coronary pathology compared with healthy controls. Significantly increased levels of depression were also found, as well as higher scores on the FIQ scale. On multivariate analysis, a positive correlation was demonstrated between tenderness/FIQ scores and a composite cardiological score.ConclusionCoronary angiography is associated with a significantly increased frequency of pain, tenderness, and depression after 6 mo, apparent in both patients undergoing coronary procedures and patients with normal coronaries. This association may impact the outcome of patients with significant coronary disease. Copyright © 2008 Wiley Periodicals, Inc.
Intracellular uptake and inhibitory activity of aromatic fluorinated amino acids in human breast cancer cells
Authors: Giese Christoph , Lepthien Sandra , Metzner Linda , Brandsch Matthias , Budisa Nediljko , Lilie Hauke 
Published: August 2008

AbstractNonproteinogenic amino acids that either occur naturally or are synthesized chemically are becoming important tools in modern drug discovery. In this context, fluorinated amino acids have great potential in the development of novel pharmaceuticals and drugs. To assess whether different fluorinated aromatic amino acid analogues of phenylalanine, tyrosine, and tryptophan are potentially interesting as therapeutic drugs, we examined their cytostatic and cytotoxic effects on the growth of the human breast cancer cell line MCF‐7. Of all the tested analoguesL‐4‐fluorotryptophan,L‐6‐fluorotryptophan andL‐p‐fluorophenylalanine effectively and irreversibly inhibited cell growth with IC50values in the low micromolar range (3–15 μM). Additionally, usingL‐4‐[14C]fluorotryptophan, andL‐6‐[14C]fluorotryptophan, we discovered that the cellular uptake of these fluorinated amino acids occurs through active transport with a 70‐fold excess of intracellular over extracellular concentrations. We identified system L as the responsible amino acid transporter. Our findings fully support the idea that fluorinated aromatic amino acid analogues are promising chemotherapeutics with the potential for use in combination with classical cancer therapy, and as new cytotoxic drugs for certain tumor types such as melanoma.
Optimal dose and schedule of an HER‐2/neu (E75) peptide vaccine to prevent breast cancer recurrence
Authors: Holmes Jarrod P. , Gates Jeremy D. , Benavides Linda C. , Hueman Matthew T. , Carmichael Mark G. , Patil Ritesh , Craig Dianna , Mittendorf Elizabeth A. , Stojadinovic Alexander , Ponniah Sathibalan , Peoples George E. 
Published: August 2008

AbstractBACKGROUND.E75, a HER‐2/neu‐derived peptide, was administered as a preventive vaccine with granulocyte‐macrophage–colony‐stimulating factor (GM‐CSF) in disease‐free lymph node‐positive (NP) and lymph node‐negative (NN) breast cancer (BCa) patients. The optimal biologic dose (OBD) was determined based on toxicity and immunologic response.METHODS.Patients were vaccinated over 6 months (3, 4, or 6 times) with different doses of E75 plus GM‐CSF. Toxicities were graded per National Cancer Institute Common Terminology Criteria. GM‐CSF was reduced for significant toxicity. Immunologic response was measured by delayed type hypersensitivity test (DTH), and E75‐specific CD8+ T‐cells were quantified with human leukocyte antigen‐A2:immunoglobulin G dimer and flow cytometry.RESULTS.Ninety‐nine patients (48 NP and 51 NN) were vaccinated in 7 dose groups. The OBD was 1000 μg E75 plus 250 μg GM‐CSF monthly × 6. The optimal dose group (ODG, n = 29) experienced similar toxicities to the suboptimal dose group (SDG, n = 70), which was comprised of the remaining 6 groups. The ODG demonstrated a trend toward an increase in the average postvaccine dimer (0.87 ± 0.10% vs 0.67 ± 0.05%; P = .07), a significantly larger DTH response (21.5 ± 2.5 mm vs 11.3 ± 1.3 mm; P = .0002), and a trend toward decreased recurrences (3.4% vs 12.9%; P = .27). Compared with the SDG, the ODG had larger tumors (percentage ≥T2: 55% vs 23%; P = .004), more positive lymph nodes (percentage NP: 76% vs 37%; P = .001), and higher grade tumors (percentage grade 3: 52% vs 30%; P = .07), but a shorter median follow‐up time (20 months vs 32 months; P < .001).CONCLUSIONS.Compared with suboptimally dosed patients, the optimally dosed E75 vaccine in disease‐free BCa patients had similar toxicity but enhanced HER‐2/neu‐specific immunity that may lead to decreased recurrences with additional follow‐up. Cancer 2008. Published 2008 by the American Cancer Society.
Reproductive and hormonal risk factors for postmenopausal luminal, HER‐2‐overexpressing, and triple‐negative breast cancer
Authors: Phipps Amanda I. , Malone Kathleen E. , Porter Peggy L. , Daling Janet R. , Li Christopher I. 
Published: August 2008

AbstractBACKGROUND.Molecular profiling studies have identified subtypes of breast cancer that can be approximately classified by estrogen receptor (ER), progesterone receptor (PR), and HER‐2/neu (HER‐2) expression. These molecular subtypes are prognostically significant, but to the authors' knowledge, differences in their etiologic profiles have not been established. Reproductive factors may plausibly be differentially correlated with the risk of different breast cancer subtypes because these factors are presumed to impact exposure to endogenous sex hormones.METHODS.The authors pooled 2 population‐based, case–control studies of breast cancer in women ages 55 to 79 years for an analysis including 1476 controls and 1023 cases of luminal breast cancer, 39 cases of HER‐2‐overexpressing breast cancer, and 78 cases of triple‐negative breast cancer. Polytomous logistic regression was used to compare each case group with controls.RESULTS.Associations varied by molecular subtype. Early age at menarche was only found to be associated with risk of HER‐2‐overexpressing disease (odds ratio [OR] of 2.7; 95% confidence interval [95% CI], 1.4‐5.5), whereas breastfeeding for ≥6 months was only found to be protective for luminal and triple‐negative disease (OR of 0.8 [95% CI, 0.6‐1.0] and OR of 0.5 [95% CI, 0.3‐0.9], respectively). Both late age at menopause and the use of estrogen plus progestin hormone therapy were only found to be associated with risk of luminal disease (OR of 1.6 [95% CI, 1.1‐2.2] and OR of 1.7 [95% CI, 1.3‐2.1], respectively). No differences in risks associated with parity or age at first live birth were observed by subtype.CONCLUSIONS.Certain reproductive factors may have a greater impact on the risk of certain molecular subtypes of disease compared with others. Future studies that further define the etiology of breast cancer subtypes will add to the biologic understanding of this disease. Cancer 2008. © 2008 American Cancer Society.
Incense use and respiratory tract carcinomas
Authors: Friborg Jeppe T. , Yuan Jian‐Min , Wang Renwei , Koh Woon‐Puay , Lee Hin‐Peng , Yu Mimi C. 
Published: August 2008

AbstractBACKGROUND.Incense use is an integral part of daily life in large parts of Asia. The burning of incense is a powerful producer of particulate matter and the smoke contains a multitude of well‐characterized carcinogens. However, to the authors' knowledge, no convincing association has been reported between exposure to incense smoke and the development of cancer. Therefore, the relation between incense use and the risk of respiratory tract carcinomas was analyzed in a prospective cohort study.METHODS.Between 1993 and 1998, a population‐based cohort of 61,320 Singapore Chinese who were free of cancer and ages 45 to 74 years completed a comprehensive interview regarding living conditions and dietary and lifestyle factors. Through linkage to population‐based registries, the cohort was followed through 2005 and cancer occurrence determined. The relative risk for these cancers associated with incense use was estimated using a Cox proportional hazards model.RESULTS.A total of 325 upper respiratory tract (UPT) carcinomas and 821 lung carcinomas were observed during follow‐up. Incense use was associated with a significantly increased risk of UPT carcinomas other than nasopharyngeal, whereas no overall effect was observed on lung cancer. The duration and intensity of incense use were associated with an increased risk of squamous cell carcinomas in the entire respiratory tract (P for trend = .004), whereas there was no significant association noted between incense use and nonsquamous cell carcinomas. The relative risk of squamous cell carcinomas among long‐term incense users was 1.8 (95% confidence interval [95% CI], 1.2‐2.6; P = .004) in the entire respiratory tract.CONCLUSIONS.The results of the current study indicate that long‐term use of incense is associated with an increased risk of squamous cell carcinoma of the respiratory tract. Cancer 2008. © 2008 American Cancer Society.
Afferent connections of septal nuclei of the domestic chick (Gallus domesticus): A retrograde pathway tracing study
Authors: Montagnese Catherine M. , Zachar Gergely , Bálint Eszter , Csillag András 
Published: August 2008

AbstractThe afferents to the septum of the domestic chicken were studied using retrograde tracers, rhodamine conjugated latex bead or Fast Blue, placed in different septal subregions. The results were verified by anterograde tracer injections deposited to selected areas. The main telencephalic afferents to the septum arise ipsilaterally from the hippocampal formation, dorsolateral corticoid area, piriform cortex, amygdaloid pallium, and the ventral pallidum. Contralateral afferents originate from the lateral septum and the amygdaloid pallium. A massive bilateral projection arises from the lateral hypothalamus. Other hypothalamic afferents arise from the periventricular, paraventricular and anterior medial nuclei, and the premammillary and mammillary areas. The dorsal thalamic nuclei (dorsal medial anterior and posterior) and the reticular dorsal nuclei also contribute septal afferents. Brainstem afferents arise bilaterally from the ventral tegmental area, substantia nigra, central gray, A8, locus coeruleus, ventral subcoeruleus nucleus, and raphe nuclei. The main terminal fields for septal afferents lie in the lateral septal nucleus and the belt of medial septal nucleus. The core of the latter is invaded mainly by fibers from the brainstem, presumably belonging to the ascending activating system. The septal afferents of the chicken are largely similar to those of other avian and nonavian species. The most prominent differences with previous pigeon data were found in the subregional selectivity of the hippocampal formation, dorsolateral corticoid area, mammillary nuclei, some dorsal thalamic nuclei, substantia nigra, and subcoeruleus nuclei in their projections to defined septal nuclei. J. Comp. Neurol. 511:109–150, 2008. © 2008 Wiley‐Liss, Inc.
Fault‐tolerant execution of large parameter sweep applications across multiple VOs with storage constraints
Authors: Ayyub Shahaan , Abramson David , Enticott Colin , Garic Slavisa , Tan Jefferson 
Published: August 2008

AbstractApplications that span multiple virtual organizations (VOs) are of great interest to the e‐science community. However, our recent attempts to execute large‐scale parameter sweep applications (PSAs) for real‐world climate studies with the Nimrod/G tool have exposed problems in the areas of fault tolerance, data storage and trust management. In response, we have implemented a task‐splitting approach that facilitates breaking up large PSAs into a sequence of dependent subtasks, improving fault tolerance; provides a garbage collection technique that deletes unnecessary data; and employs a trust delegation technique that facilitates flexible third party data transfers across different VOs. Copyright © 2008 John Wiley & Sons, Ltd.
Towards in Silico Liquid Crystals. Realistic Transition Temperatures and Physical Properties for n‐Cyanobiphenyls via Molecular Dynamics Simulations
Authors: Tiberio Giustiniano , Muccioli Luca , Berardi Roberto , Zannoni Claudio 
Published: August 2008

AbstractWe study the important n‐cyanobiphenyl (with n= 4–8) series of mesogens, using modelling and molecular dynamics simulations. We are able to obtain spontaneously ordered nematics upon cooling isotropic samples of 250 molecules. By using the united‐atom force field developed herein, we show that the experimental isotropic–nematic transition temperatures are reproduced within 4 K, allowing a molecular‐level interpretation of the odd–even effect along the series. Other properties, like densities, orientational order parameters and NMR residual dipolar couplings are also reproduced well, demonstrating the feasibility of predictive in silico modelling of nematics from the molecular structure.
Structural study of the semimagnetic semiconductor Zn0.5Mn0.5In2Te4
Authors: Delgado G. E. , Sagredo V. 
Published: August 2008

AbstractThe semimagnetic semiconductor alloy Zn0.5Mn0.5In2Te4 was refined from an X‐ray powder diffraction pattern using the Rietveld method. This compound crystallizes in the space group I42m (Nº 121), Z = 2, with unit cell parameters a = 6.1738(1) Å, c = 12.3572(4) Å, V = 471.00(2) Å3, c/a = 2.00. This material crystallizes in a stannite‐type structure. (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)