bluuebunny/crossref_metadata_2025_split huggingface dataset:
Selective protein quantification on continuous chromatography equipment with limited absorbance sensing: A partial least squares and statistical wavelength selection solution
Authors: Gough Ian A. , Rassenberg Sarah , Velikonja Claire , Corbett Brandon , Latulippe David R. , Mhaskar Prashant 
Published: March 2024

AbstractReal‐time selective protein quantification is an integral component of operating continuous chromatography processes. Partial least squares models fit with spectroscopic UV‐Vis absorbance data have demonstrated the ability to selectively quantify proteins. With standard continuous chromatography equipment that is only capable of measuring absorbance at a few user‐defined wavelengths, the problem of selecting appropriate wavelengths that maximize the measurement capability of the instrument remains unaddressed. Therefore, we propose a method for selecting wavelengths for continuous chromatography equipment. We illustrate our method using sets of protein mixtures composed of bovine serum albumin and lysozyme. The first step is to refine the raw wavelength set with a statistical t‐test and an absorbance magnitude test. Then, the wavelengths within the refined spectroscopic range are ranked. Three existing techniques are evaluated – sequential forward search, variable importance to projection scores, and the least absolute shrinkage and selection operator. The best technique (in this case, sequential forward search) determines a subset of three wavelengths for further evaluation on the BioSMB PD. We use an exhaustive approach to determine the final wavelength set. We show that soft sensor models trained from the method's wavelength selections can quantify the two proteins more accurately than from the wavelength set of 230, 260 and 280 nm, by a factor of four. The method is shown to determine appropriate wavelengths for different path lengths and protein concentration ranges. Overall, we provide a tool that alleviates the analytical bottleneck for practitioners seeking to develop advanced monitoring and control methods on standard equipment.
Construction of Ultrafine PtIr Clusters Supported on Co3O4 Nanoflowers for Enhanced Overall Water Splitting
Authors: Zhang Longtao , Zhang Mingliang , Zhang Yu , Zhuo Wei , Chen Tong , Fang Yilin , Hong Jiaxiang , Wei Hehe , Gong Xue‐Qing 
Published: March 2024

AbstractGreen hydrogen production through electrochemical overall water splitting has suffered from sluggish oxygen evolution reaction (OER) kinetics, inferior conversion efficiency, and high cost. Herein, ultrafine PtIr clusters are synthesized via an electrodeposition method and decorated on the Co3O4 nanoflowers assembled by nanowires (PtIr‐Co3O4). The encouraging performances in electrochemical OER and hydrogen evolution reaction (HER) are achieved over the PtIr‐Co3O4 catalyst, with the overpotentials as low as 410 and 237 mV at 100 mA cm−2, respectively, outperforming the commercial IrO2 and Pt/C catalysts. Due to the ultralow loading of PtIr clusters, the PtIr‐Co3O4 catalyst exhibits 1270 A gIr−1 for OER at the overpotential of 400 mV. Our detailed analyses also show that the strong interactions between the ultrafine PtIr clusters and the Co3O4 nanoflowers enable the PtIr‐Co3O4 catalyst to afford 10 mA cm−2 for the overall water splitting at the potential of 1.57 V, accompanied by high durability for 100 h.
Heteroatom‐Promoted Polyhexagonal Saddle‐Shaped Molecular Structures and their Supramolecular Coassembly with C60
Authors: Thilagar Pakkirisamy , Nandi Rajendra Prasad , Ghosh Subhajit 
Published: March 2024

AbstractMolecules with curved architecture can exhibit unique optoelectronic properties due to the concave‐convex π‐surface. However, synthesizing negatively curved saddle‐shaped aromatic systems has been challenging due to the internal structural strain. Herein, we report the facile synthesis of two polyhexagonal molecular systems, 1 and 2, with saddle shape geometry by judiciously varying the aromatic moiety, avoiding the harsh synthetic methods as that of heptagonal aromatic saddle systems. The unique geometry preferences of B, N, and S furnish suitable curvature to the molecules, featuring saddle shape. The saddle geometry also enables them to interact with fullerene C60, and the supramolecular interactions of fullerene C60 with 1 and 2 modify their optoelectronic properties. Crystal structure analysis reveals that 1, with a small π‐surface, forms a double columnar array of fullerenes in the solid state. In contrast, 2 with a large π‐surface produces a supramolecular capsule entrapping two discrete fullerenes. The intermolecular interactions between B, N, S, and the aryl‐π surface of the host and C60 guest are the stabilizing factors for creating these supramolecular structures. Comprehensive computational, optical, and Raman spectroscopic studies establish the charge transfer interactions between B−N doped heterocycle host and fullerene C60 guest.
Pancreatic Crosstalk in the Disease Setting: Understanding the Impact of Exocrine Disease on Endocrine Function
Authors: Villaca Catharina B.P. , Mastracci Teresa L. 
Published: March 2024

Abstract

The exocrine and endocrine are functionally distinct compartments of the pancreas that have traditionally been studied as separate entities. However, studies of embryonic development, adult physiology, and disease pathogenesis suggest there may be critical communication between exocrine and endocrine cells. In fact, the incidence of the endocrine disease diabetes secondary to exocrine disease/dysfunction ranges from 25% to 80%, depending on the type and severity of the exocrine pathology. Therefore, it is necessary to investigate how exocrine‐endocrine “crosstalk” may impact pancreatic function. In this article, we discuss common exocrine diseases, including cystic fibrosis, acute, hereditary, and chronic pancreatitis, and the impact of these exocrine diseases on endocrine function. Additionally, we review how obesity and fatty pancreas influence exocrine function and the impact on cellular communication between the exocrine and endocrine compartments. Interestingly, in all pathologies, there is evidence that signals from the exocrine disease contribute to endocrine dysfunction and the progression to diabetes. Continued research efforts to identify the mechanisms that underlie the crosstalk between various cell types in the pancreas are critical to understanding normal pancreatic physiology as well as disease states. © 2024 American Physiological Society.
Compr Physiol
14:5371‐5387, 2024.
Sustainability policies adoption within Italian Michelin‐starred restaurants: From external drivers to costs
Authors: Gazzola Patrizia , Vătămănescu Elena‐Mădălina , Zamai Matilde , Fassio Franco 
Published: March 2024

AbstractThe purpose of the research is to investigate the increasing importance of the role of sustainability in high‐end restaurants, specifically in those awarded Michelin stars. The focus is on the role sustainability plays as a crucial element in the state‐of‐the‐art of fine‐dining business given that restaurants are challenged to reconsider the noteworthiness of new sustainable imperatives. The study is based on a questionnaire survey carried out with over 70 owners and chefs from Italian Michelin‐starred restaurants. The results show a clear tendency towards sustainability and an increasing attention towards this trend, emphasizing its peculiarities for the restaurant industry, which is indicates profound changes. More specifically, 35% of the variance in internal sustainability policies adoption is explained by external drives related to sustainability and customers' demands of sustainability. The data collected relies on an Italian sample, but the results are useful to understand the sustainability imperatives for the Michelin‐stars restaurants worldwide as the Italian food service industry is often deemed as iconic. The study advances new insights into the future of the sustainable restaurant industry. The results of research are based on a novel research design and empirical survey capturing the state‐of‐the‐art of sustainability policies adoption in the case of Michelin‐starred restaurants.
Modified elliptic response bandpass filtering integrated high‐efficiency GaN MMIC power amplifier at 24–28 GHz
Authors: Dong Qin , Zhu Xiao‐Wei , Liu Rui‐Jia , Zhao Zi Ming , Chen Peng , Yang Xian‐Long , Cao Yang 
Published: March 2024

SummaryIn this paper, an out‐of‐band suppression enhanced high‐efficiency millimeter‐wave (mm‐wave) gallium nitride (GaN) microwave monolithic integrated circuit (MMIC) filtering power amplifier (FPA) is presented. A modified elliptic response bandpass filtering (BPF) output matching network (OMN) is used to achieve low loss and high out‐of‐band rejection. The circuit of the presented BPF OMN is given and its synthesized method is introduced. The simulated S‐parameters show that the OMN has a low‐loss in‐band response and a desired out‐of‐band rejection performance with two transmission zeros (TZs). To demonstrate this idea, a two‐stage 24–28‐GHz GaN MMIC PA is designed and implemented in a 0.15‐μm GaN‐on‐SiC process, with a mask area of 2.4 × 1.0 mm2. Experimental results show that the realized MMIC PA achieves a small signal gain of 18.8 dB from 24 to 28 GHz with ±1.2‐dB gain flatness and 40‐dB rejection at 19.43 and 33.8 GHz. The saturated power‐added efficiency (PAE) is higher than 29% from 24 to 28 GHz, with a peak PAE of 36.3% at 27 GHz. The output power is within the range of 33.8 to 35.6 dBm in the operating band. For a 100‐MHz five‐carrier LTE signal, the PA can achieve ACLR better than −40 dBc over the band with digital predistortion.
A Lambert importance model‐based reliability design method for power converters in switched reluctance motor systems
Authors: Xu Shuai , Zeng Hui , Qi Ge , Song Fuhu , Liu Chen 
Published: March 2024

SummaryThe reliability of power converters is crucial for achieving high‐performance operation in switched reluctance motor (SRM) systems. However, there is a notable deficiency in reliability‐oriented design of power converters that can effectively integrate both static and dynamic reliability indicators. To address this issue, this paper proposes a reliability design methodology for power converters based on the Lambert importance model, aimed at enhancing reliability of SRM systems. Firstly, the modeling principles of Lambert importance model are presented. Subsequently, a reliability design method is proposed to maximize reliability within a unit economic cost framework. Especially, the proposed design scheme is designed to maximize reliability enhancement potential through a two‐pronged approach: strategic topology selection informed by potential reliability assessments and component selection guided by importance calculations. Meanwhile, dynamic reliability evaluation is carried out to form a double‐loop reliability feedback and increase the credibility of design scheme. Finally, an example is developed to verify the validity of proposed reliability design scheme.
Progress and challenges of in vivo flow cytometry and its applications in circulating cells of eyes
Authors: Lin Wei , Wang Peng , Qi Yingxin , Zhao Yanlong , Wei Xunbin 
Published: March 2024

AbstractCirculating inflammatory cells in eyes have emerged as early indicators of numerous major diseases, yet the monitoring of these cells remains an underdeveloped field. In vivo flow cytometry (IVFC), a noninvasive technique, offers the promise of real‐time, dynamic quantification of circulating cells. However, IVFC has not seen extensive applications in the detection of circulating cells in eyes, possibly due to the eye's unique physiological structure and fundus imaging limitations. This study reviews the current research progress in retinal flow cytometry and other fundus examination techniques, such as adaptive optics, ultra‐widefield retinal imaging, multispectral imaging, and optical coherence tomography, to propose novel ideas for circulating cell monitoring.
The association between gender‐affirming care and disordered eating in transgender and gender diverse individuals: Exploring appearance congruence and gender‐related motivating factors for weight loss
Authors: Chakkour Em , Simone Melissa , Askew Autumn J. , Blashill Aaron J. 
Published: March 2024

AbstractObjectiveThe objective of this study is to explore between‐group differences across different stages of gender‐affirming care, and associations between appearance congruence, gender‐related motivations for weight loss, and disordered eating in transgender and gender expansive (TGE) individuals.MethodA total of 160 TGE adults (aged 18–30) were recruited across the United States. Participants completed a comprehensive online survey. Data were analyzed using generalized linear models and bivariate correlations.ResultsSignificant differences in appearance congruence among participants at different transition stages were revealed, with the group that achieved their desired transition reporting the highest appearance congruence compared to all other groups. Furthermore, gender‐related motivations for weight loss were significantly lower in individuals who achieved their desired transition compared to those with no plans to transition.DiscussionFindings suggest significantly higher appearance congruence in those who achieved their desired transition compared to other groups, and individuals who attained their desired transition exhibited significantly reduced gender‐related motivations for weight loss compared to those with no plans to transition. These findings underscore the potential psychological benefits associated with successful gender‐affirming care, highlighting its role not only in fostering appearance congruence but also in mitigating gender‐related motivations for weight loss among TGE individuals. Future research should include larger and more diverse samples, longitudinal designs, and considerations of other factors influencing body image outcomes in this population.Public SignificanceThis study sheds light on the crucial relationship between gender‐affirming care and body image outcomes in TGE individuals. Understanding how appearance congruence and gender‐related motivations for weight loss are associated with disordered eating can inform tailored support and interventions. By recognizing the association of gender affirming care and well‐being, healthcare providers can enhance care for TGE individuals.
Round‐robin test of all‐solid‐state battery with sulfide electrolyte assembly in coin‐type cell configuration
Authors: Beutl Alexander , Orue Ander , López‐Aranguren Pedro , Itziar Pitillas Martinez Andrea , Braga Maria Helena , Kekkonen Ville , Tron Artur 
Published: March 2024

AbstractThe replacement of conventional lithium‐ion batteries with solid‐state batteries is currently under investigation by many players both from academia and industry. Sulfide‐based electrolytes are among the materials that are regarded as most promising, especially for application in the transport sector. The performance of anode, cathode, and solid electrolyte materials of this type of solid electrolyte is typically evaluated using manually assembled cells such as Swagelok cells, EL‐CELLs, and in‐house built pressure devices. Coin cells, however, are often disregarded. Though coin cells cannot accurately predict how a material will perform in an end‐use application battery cell format, they are easy to assemble and can provide reproducible data compared to the other cell types, which make them an interesting option for testing the materials under conditions more relevant for their envisioned application. The coin cell preparation method presented in this work has been evaluated interlaboratory for reproducibility and, in addition, can be modified depending on the optimization parameters of the solid electrolyte, cathode material, bilayer comprised on cathode and solid electrolyte, lithium metal anode, and cell in general. Besides, an interlab round‐robin test (RRT) is carried out between four laboratories, measuring defined electrochemical tests of sulfide solid‐state batteries in coin cell configuration. This RRT for the preparation of coin cell solid‐state batteries with sulfide solid electrolyte, lithium nickel manganese cobalt oxides cathode, and lithium metal anode is intended for academic researchers and provides guidelines of research in this field.
ChatGPT versus Bard: A comparative study
Authors: Ahmed Imtiaz , Kajol Mashrafi , Hasan Uzma , Datta Partha Protim , Roy Ayon , Reza Md. Rokonuzzaman 
Published: March 2024

AbstractThe rapid progress in conversational AI has given rise to advanced language models capable of generating human‐like texts. Among these models, ChatGPT and Bard, developed by OpenAI and Google AI respectively, have gained significant attention. With their wide range of functionalities, such as human‐like response generation, proficiency in professional exams, complex problem solving, and more, these models have captured interest. This study presents a comprehensive survey exploring and comparing the capabilities and features of ChatGPT and Bard. We delve into their architectures, training methodologies, performance evaluations, and limitations across various domains. Ethical considerations such as biases and potential misconduct are also examined. Our findings highlight ChatGPT's exceptional performance, positioning it as a leading model. This survey is a vital resource for scholars, innovators, and interested parties operating within the domain of conversational artificial intelligence, offering valuable insights for the advancement of cutting‐edge language models.
Notes on Asian Orchidaceae – I: Cremastra appendiculata var. appendiculata and Hemipilia nana
Authors: Kumar Pankaj 
Published: March 2024

AbstractNervilia gleadowii described from Western Himalaya and Cremastra amabilis described from China, are placed under the synonymy of Cremastra appendiculata var. appendiculata based on morphological similarities. Orchis chusua var. nana is resurrected at species rank, and, to accommodate it in the genus Hemipilia, following the current taxonomic trends, a new combination of Hemipilia nana is published. This name had six syntypes available (all belonging to R. Pantling 326), one of which is designated here as a lectotype. Apetalanthe gracilis described from Vietnam, is reduced to the synonymy of H. nana and accordingly, Apetalanthe is reduced to Hemipilia (because A. gracilis is the type species of this monotypic genus).
Can pain be self‐managed? Pain change in vulnerable participants to a health education programme
Authors: Faurie Charlotte , Alvergne Alexandra , Cheng Demi , Duflos Claire , Elstgeest Liset , Ferreira Rosanna , Raat Hein , Valsecchi Verushka , Pilotto Alberto , Baker Graham , Pisano Marta M. , Pers Yves‐Marie 
Published: March 2024

AbstractChronic pain exerts a significant impact on the quality of life, giving rise to both physical and psycho‐social vulnerabilities. It not only leads to direct costs associated with treatments, but also results in indirect costs due to the reduced productivity of affected individuals. Chronic conditions can be improved by reducing modifiable risk factors. Various educational programs, including the Chronic Disease Self‐Management Programme (CDSMP), have demonstrated the advantages of enhancing patient empowerment and health literacy. Nevertheless, their efficacy in addressing pain symptoms has received limited attention, especially concerning vulnerable populations. This research aims to assess the effectiveness of the CDSMP in alleviating pain among socio‐economically vulnerable participants with chronic conditions. By accounting for a wide range of variables, and using data from the EFFICHRONIC project (EU health programme), we investigated the changes in pain levels after the intervention, among 1070 participants from five European countries. Our analyses revealed a significant reduction in pain following the intervention. This finding supports the notion that training programs can effectively ameliorate pain and alleviate its impact on the quality of life, particularly in vulnerable populations. Younger participants, as well as those with higher education levels and individuals experiencing higher levels of pain at baseline, were more likely to experience a reduction in their pain levels. These findings underscore the importance of recognising the social determinants of health.The study was registered at ClinicalTrials.gov (ISRCTN70517103).
Characterization of Mitoribosomal Small Subunit unit genes related immune and pharmacogenomic landscapes in renal cell carcinoma
Authors: Wei Zhihao , Liu Chenchen , Liang Jiaqian , Zhou Xuan , Xue Kaming , Wang Keshan , Zhang Xiaoping 
Published: March 2024

AbstractMitoribosomes are essential for the production of biological energy. The Human Mitoribosomal Small Subunit unit (MRPS) family, responsible for encoding mitochondrial ribosomal small subunits, is actively engaged in protein synthesis within the mitochondria. Intriguingly, MRPS family genes appear to play a role in cancer. A multistep process was employed to establish a risk model associated with MRPS genes, aiming to delineate the immune and pharmacogenomic landscapes in clear cell renal cell carcinoma (ccRCC). MRPScores were computed for individual patients to assess their responsiveness to various treatment modalities and their susceptibility to different therapeutic targets and drugs. While MRPS family genes have been implicated in various cancers as oncogenes, our findings reveal a contrasting tumor suppressor role for MRPS genes in ccRCC. Utilizing an MRPS‐related risk model, we observed its excellent prognostic capability in predicting survival outcomes for ccRCC patients. Remarkably, the subgroup with high MRPS‐related scores (MRPScore) displayed poorer prognosis but exhibited a more robust response to immunotherapy. Through in silico screening of 2183 drug targets and 1646 compounds, we identified two targets (RRM2 and OPRD1) and eight agents (AZ960, carmustine, lasalocid, SGI‐1776, AZD8055_1059, BPD.00008900_1998, MK.8776_2046, and XAV939_1268) with potential therapeutic implications for high‐MRPScore patients. Our study represents the pioneering effort in proposing that molecular classification, diagnosis, and treatment strategies can be formulated based on MRPScores. Indeed, a high MRPScore profile appears to elevate the risk of tumor progression and mortality, potentially through its influence on immune regulation. This suggests that the MRPS‐related risk model holds promise as a prognostic predictor and may offer novel insights into personalized therapeutic strategies.
Preferences and willingness to pay for a novel carbon label: A choice experiment in the United States
Authors: Lin Wen , Nayga Rodolfo M. , Yang Wei 
Published: March 2024

AbstractThis study investigates how US consumers respond to and value a new technology‐based carbon label on food products. Results indicate that individual valuation of the carbon‐labeled bread is $4/20 oz, marginally lower than the valuation of the conventional and organic bread products. Moreover, individuals belonging to certain market segments, such as non‐White, liberal, and well‐educated consumers, and those having a high level of knowledge about the causes of climate change, exhibit a higher valuation for the novel carbon label.