bluuebunny/crossref_metadata_2025_split huggingface dataset:
Observed 1970–2005 Cooling of Summer Daytime Temperatures in Coastal California
Authors: Lebassi Bereket , González Jorge , Fabris Drazen , Maurer Edwin , Miller Norman , Milesi Cristina , Switzer Paul , Bornstein Robert 
Published: November 2008

AbstractThis study evaluated 1950–2005 summer [June–August (JJA)] mean monthly air temperatures for two California air basins: the South Coast Air Basin (SoCAB) and the San Francisco Bay Area (SFBA). The study focuses on the more rapid post-1970 warming period, and its daily minima temperature Tmin and maxima temperature Tmax values were used to produce average monthly values and spatial distributions of trends for each air basin. Additional analyses included concurrent SSTs, 40-yr European Centre for Medium-Range Weather Forecasts (ECMWF) Re-Analysis (ERA-40) sea level coastal pressure gradients, and GCM-downscaled average temperature Tave values.Results for all 253 California National Weather Service (NWS) Cooperative Observer Program (COOP) sites together showed increased Tave values (0.23°C decade−1); asymmetric warming, as Tmin values increase faster than Tmax values (0.27° versus 0.04°C decade−1) and thus decreased daily temperature range (DTR) values (0.15°C decade−1). The spatial distribution of observed SoCAB and SFBA Tmax values exhibited a complex pattern, with cooling (−0.30°C decade−1) in low-elevation coastal areas open to marine air penetration and warming (0.32°C decade−1) in inland areas. Results also showed that decreased DTR values in the basins arose from small increases at inland sites (0.16°C decade−1) combined with large decreases (−0.58°C decade−1) at coastal sites. It is also possible that some of the current observed temperature trends could be associated with low-frequency decadal variability, expected even with a constant radiative forcing.Previous studies suggest that cooling JJA Tmax values in coastal California were a result of increased irrigation, coastal upwelling, or cloud cover. The current hypothesis is that they arise (as a possible “reverse reaction”) from the global warming of inland areas, which results in increased sea-breeze flow activity. GCM model Tave warming decreased from 0.13°C decade−1 at inland sites to 0.08°C decade−1 in coastal areas. Sea level pressure increased in the Pacific high and decreased in the thermal low. The corresponding gradient thus showed a trend of 0.04 hPa 100 km−1 decade−1, supportive of the hypothesis of increased sea-breeze activity.
Arctic Cloud Fraction and Radiative Fluxes in Atmospheric Reanalyses
Authors: Walsh John E. , Chapman William L. , Portis Diane H. 
Published: November 2008

Abstract
Arctic radiative fluxes, cloud fraction, and cloud radiative forcing are evaluated from four currently available reanalysis models using data from the North Slope of Alaska (NSA) Barrow site of the Atmospheric Radiation Measurement Program (ARM). A primary objective of the ARM–NSA program is to provide a high-resolution dataset of direct measurements of Arctic clouds and radiation so that global climate models can better parameterize high-latitude cloud radiative processes. The four reanalysis models used in this study are the 1) NCEP–NCAR global reanalysis, 2) 40-yr ECMWF Re-Analysis (ERA-40), 3) NCEP–NCAR North American Regional Reanalysis (NARR), and 4) Japan Meteorological Agency and Central Research Institute of Electric Power Industry 25-yr Reanalysis (JRA25). The reanalysis models simulate the radiative fluxes well if/when the cloud fraction is simulated correctly. However, the systematic errors of climatological reanalysis cloud fractions are substantial. Cloud fraction and radiation biases show considerable scatter, both in the annual mean and over a seasonal cycle, when compared to those observed at the ARM–NSA. Large seasonal cloud fraction biases have significant impacts on the surface energy budget. Detailed comparisons of ARM and reanalysis products reveal that the persistent low-level cloud fraction in summer is particularly difficult for the reanalysis models to capture creating biases in the shortwave radiation flux that can exceed 160 W m−2. ERA-40 is the best performer in both shortwave and longwave flux seasonal representations at Barrow, largely because its simulation of the cloud coverage is the most realistic of the four reanalyses. Only two reanalyses (ERA-40 and NARR) capture the observed transition from positive to negative surface net cloud radiative forcing during a 2–3-month period in summer, while the remaining reanalyses indicate a net warming impact of Arctic clouds on the surface energy budget throughout the entire year. The authors present a variable cloud radiative forcing metric to diagnose the erroneous impact of reanalysis cloud fraction on the surface energy balance. The misrepresentations of cloud radiative forcing in some of the reanalyses are attributable to errors in both simulated cloud amounts and the models’ radiative response to partly cloudy conditions.
Hindcasts of Tropical Atlantic SST Gradient and South American Precipitation: The Influences of the ENSO Forcing and the Atlantic Preconditioning
Authors: Huang Huei-Ping , Robertson Andrew W. , Kushnir Yochanan , Peng Shiling 
Published: November 2008

Abstract
Hindcast experiments for the tropical Atlantic sea surface temperature (SST) gradient G1, defined as tropical North Atlantic SST anomaly minus tropical South Atlantic SST anomaly, are performed using an atmospheric general circulation model coupled to a mixed layer ocean over the Atlantic to quantify the contributions of the El Niño–Southern Oscillation (ENSO) forcing and the preconditioning in the Atlantic to G1 in boreal spring. The results confirm previous observational analyses that, in the years with a persistent ENSO SST anomaly from boreal winter to spring, the ENSO forcing plays a primary role in determining the tendency of G1 from winter to spring and the sign of G1 in late spring. In the hindcasts, the initial perturbations in Atlantic SST in boreal winter are found to generally persist beyond a season, leaving a secondary but nonnegligible contribution to the predicted Atlantic SST gradient in spring. For 1993/94, a neutral year with a large preexisting G1 in winter, the hindcast using the information of Atlantic preconditioning alone is found to reproduce the observed G1 in spring. The seasonal predictability in precipitation over South America is examined in the hindcast experiments. For the recent events that can be validated with high-quality observations, the hindcasts produced dryness in boreal spring 1983, wetness in spring 1996, and wetness in spring 1994 over northern Brazil that are qualitatively consistent with observations. An inclusion of the Atlantic preconditioning is found to help the prediction of South American rainfall in boreal spring. For the ENSO years, discrepancies remain between the hindcast and observed precipitation anomalies over northern and equatorial South America, an error that is partially attributed to the biased atmospheric response to ENSO forcing in the model. The hindcast of the 1993/94 neutral year does not suffer this error. It constitutes an intriguing example of useful seasonal forecast of G1 and South American rainfall anomalies without ENSO.
A Simple Dynamical Model of the Warm-Water Branch of the Middepth Meridional Overturning Cell
Authors: Samelson R. M. 
Published: November 2008

AbstractA reduced-gravity model is presented of the warm-water branch of the middepth meridional overturning circulation in a rectangular basin with a circumpolar connection. The model describes the balance between production of warm water by Ekman advection across the circumpolar current, dissipation of warm water by eddy fluxes southward across the current, and the net production or dissipation of warm water by diabatic processes north of the current. The results emphasize the role of the eastern boundary condition in setting the thermocline structure north of the current and the nonlinear interactions between wind forcing, eddy fluxes, and diabatic mixing, which together control the structure and amplitude of the model meridional overturning circulation. Solutions are shown to exist in which the northward Ekman transport across the circumpolar current is completely compensated by southward eddy fluxes and the meridional overturning north of the current is entirely driven by diabatic forcing and interior upwelling through the base of the layer. Other solutions are shown to exist in which the interior upwelling into the warm layer at midlatitudes is negligible and the meridional overturning circulation consists of a continuous cell that carried the fluid delivered by the northward Ekman transport across the circumpolar current through midlatitudes to the Northern Hemisphere subpolar gyre, where it cools and returns to depth. The results emphasize that the coupled elements of wind driving, eddy fluxes, and diabatic processes are inextricably intertwined in the middepth meridional overturning circulation.
Improved patient survival for acute myeloid leukemia: a population-based study of 9729 patients diagnosed in Sweden between 1973 and 2005
Authors: Derolf Åsa Rangert , Kristinsson Sigurdur Yngvi , Andersson Therese M.-L. , Landgren Ola , Dickman Paul W. , Björkholm Magnus 
Published: November 2008

AbstractWe evaluated survival patterns for all registered acute myeloid leukemia (AML) patients diagnosed in Sweden in 1973 to 2005 (N = 9729; median age, 69 years). Patients were categorized into 6 age groups and 4 calendar periods (1973-1980, 1981-1988, 1989-1996, and 1997-2005). Relative survival ratios were computed as measures of patient survival. One-year survival improved over time in all age groups, whereas 5- and 10-year survival improved in all age groups, except for patients 80+ years. The 5-year relative survival ratios in the last calendar period were 0.65, 0.58, 0.36, 0.15, 0.05, and 0.01 for the age groups 0 to 18, 19 to 40, 41 to 60, 61 to 70, 71 to 80, and 80+ years, respectively. Intensified chemotherapy, a continuous improvement in supportive care, and allogeneic stem cell transplantation are probably the most important factors contributing to this finding. In contrast, there was no improvement in survival in AML patients with a prior diagnosis of a myelodysplastic syndrome during 1993 to 2005 (n = 219). In conclusion, AML survival has improved during the last decades. However, the majority of AML patients die of their disease and age remains an important predictor of prognosis. New effective agents with a more favorable toxicity profile are needed to improve survival, particularly in the elderly.
Genome-wide and expression analysis of protein phosphatase 2C in rice and Arabidopsis
Authors: Xue Tongtong , Wang Dong , Zhang Shizhong , Ehlting Juergen , Ni Fei , Jakab Stephen , Zheng Chengchao , Zhong Yuan 
Published: November 2008

Abstract

Background
The protein phosphatase 2Cs (PP2Cs) from various organisms have been implicated to act as negative modulators of protein kinase pathways involved in diverse environmental stress responses and developmental processes. A genome-wide overview of the PP2C gene family in plants is not yet available.

Results
A comprehensive computational analysis identified 80 and 78 PP2C genes in Arabidopsis thaliana (AtPP2Cs) and Oryza sativa (OsPP2Cs), respectively, which denotes the PP2C gene family as one of the largest families identified in plants. Phylogenic analysis divided PP2Cs in Arabidopsis and rice into 13 and 11 subfamilies, respectively, which are supported by the analyses of gene structures and protein motifs. Comparative analysis between the PP2C genes in Arabidopsis and rice identified common and lineage-specific subfamilies and potential 'gene birth-and-death' events. Gene duplication analysis reveals that whole genome and chromosomal segment duplications mainly contributed to the expansion of both OsPP2Cs and AtPP2Cs, but tandem or local duplication occurred less frequently in Arabidopsis than rice. Some protein motifs are widespread among the PP2C proteins, whereas some other motifs are specific to only one or two subfamilies. Expression pattern analysis suggests that 1) most PP2C genes play functional roles in multiple tissues in both species, 2) the induced expression of most genes in subfamily A by diverse stimuli indicates their primary role in stress tolerance, especially ABA response, and 3) the expression pattern of subfamily D members suggests that they may constitute positive regulators in ABA-mediated signaling pathways. The analyses of putative upstream regulatory elements by two approaches further support the functions of subfamily A in ABA signaling, and provide insights into the shared and different transcriptional regulation machineries in dicots and monocots.

Conclusion
This comparative genome-wide overview of the PP2C family in Arabidopsis and rice provides insights into the functions and regulatory mechanisms, as well as the evolution and divergence of the PP2C genes in dicots and monocots. Bioinformatics analyses suggest that plant PP2C proteins from different subfamilies participate in distinct signaling pathways. Our results have established a solid foundation for future studies on the functional divergence in different PP2C subfamilies.
Willingness and ability to pay for artemisinin-based combination therapy in rural Tanzania
Authors: Saulo Eleonor C , Forsberg Birger C , Premji Zul , Montgomery Scott M , Björkman Anders 
Published: November 2008

Abstract

Background
The aim of this study was to analyse willingness to pay (WTP) and ability to pay (ATP) for ACT for children below five years of age in a rural setting in Tanzania before the introduction of artemisinin-based combination therapy (ACT) as first-line treatment for uncomplicated malaria. Socio-economic factors associated with WTP and expectations on anti-malaria drugs, including ACT, were also explored.

Methods
Structured interviews and focus group discussions were held with mothers, household heads, health-care workers and village leaders in Ishozi, Gera and Ishunju wards in north-west Tanzania in 2004. Contingent valuation method (CVM) was used with "take-it-or-leave-it" as the eliciting method, expressed as WTP for a full course of ACT for a child and households' opportunity cost of ACT was used to assess ATP. The study included descriptive analyses with multivariate adjustment for potential confounding factors.

Results
Among 265 mothers and household heads, 244 (92%, CI = 88%–95%) were willing to pay Tanzanian Shillings (TSh) 500 (US$ 0.46) for a child's dose of ACT, but only 55% (49%–61%) were willing to pay more than TSh 500. Mothers were more often willing to pay than male household heads (adjusted odds ratio = 2.1, CI = 1.2–3.6). Socio-economic status had no significant effect on WTP. The median annual non-subsidized ACT cost for clinical malaria episodes in an average household was calculated as US$ 6.0, which would represent 0.9% of the average total consumption expenditures as estimated from official data in 2001. The cost of non-subsidized ACT represented 7.0% of reported total annual expenditure on food and 33.0% of total annual expenditure on health care.
"Rapid effect," "no adverse effect" and "inexpensive" were the most desired features of an anti-malarial drug.

Conclusion
WTP for ACT in this study was less than its real cost and a subsidy is, therefore, needed to enable its equitable affordability. The decision taken in Tanzania to subsidize Coartem® fully at governmental health care facilities and at a consumer price of TSh 300–500 (US$ 0.28–0.46) at special designated shops through the programme of Accredited Drug Dispensing Outlets (ADDOs) appears to be well founded.
Evaluation of two counterflow traps for testing behaviour-mediating compounds for the malaria vector Anopheles gambiae s.s. under semi-field conditions in Tanzania
Authors: Schmied Wolfgang H , Takken Willem , Killeen Gerry F , Knols Bart GJ , Smallegange Renate C 
Published: November 2008

AbstractBackgroundEvaluation of mosquito responses towards different trap-bait combinations in field trials is a time-consuming process that can be shortened by experiments in contained semi-field systems. Possible use of the BG Sentinel (BGS) trap to sampleAnopheles gambiae s.s.was evaluated. The efficiency of this trap was compared with that of the Mosquito Magnet-X (MM-X) trap, when baited with foot odour alone or combinations of foot odour with carbon dioxide (CO2) or lemongrass as behaviour-modifying cues.MethodsFemaleAn. gambiae s.s.were released in an experimental flight arena that was placed in a semi-field system and left overnight. Catch rates for the MM-X and BGS traps were recorded. Data were analysed by fitting a generalized linear model to the (n+1) transformed catches.ResultsBoth types of traps successfully captured mosquitoes with all odour cues used. When the BGS trap was tested against the MM-X trap in a choice assay with foot odour as bait, the BGS trap caught about three times as many mosquitoes as the MM-X trap (P = 0.002). Adding CO2(500 ml/min) to foot odour increased the number of mosquitoes caught by 268% for the MM-X (P < 0.001) and 34% (P = 0.051) for the BGS trap, compared to foot odour alone. When lemongrass leaves were added to foot odour, mosquito catches were reduced by 39% (BGS, P < 0.001) and 38% (MM-X, P = 0.353), respectively.ConclusionThe BGS trap shows high potential for field trials due to its simple construction and high catch rate when baited with human foot odour only. However, for rapid screening of different baits in a contained semi-field system, the superior discriminatory power of the MM-X trap is advantageous.
Histopathological and molecular heterogeneity among individuals with dementia associated with Presenilin mutations
Authors: Maarouf Chera L , Daugs Ian D , Spina Salvatore , Vidal Ruben , Kokjohn Tyler A , Patton R Lyle , Kalback Walter M , Luehrs Dean C , Walker Douglas G , Castaño Eduardo M , Beach Thomas G , Ghetti Bernardino , Roher Alex E 
Published: November 2008

Abstract

Background
Mutations in the presenilin (PSEN) genes are associated with early-onset familial Alzheimer's disease (FAD). Biochemical characterizations and comparisons have revealed that many PSEN mutations alter γ-secretase activity to promote accumulation of toxic Aβ42 peptides. In this study, we compared the histopathologic and biochemical profiles of ten FAD cases expressing independent PSEN mutations and determined the degradation patterns of amyloid-β precursor protein (AβPP), Notch, N-cadherin and Erb-B4 by γ-secretase. In addition, the levels of Aβ40/42 peptides were quantified by ELISA.

Results
We observed a wide variation in type, number and distribution of amyloid deposits and neurofibrillary tangles. Four of the ten cases examined exhibited a substantial enrichment in the relative proportions of Aβ40 over Aβ42. The AβPP N-terminal and C-terminal fragments and Tau species, assessed by Western blots and scanning densitometry, also demonstrated a wide variation. The Notch-1 intracellular domain was negligible by Western blotting in seven PSEN cases. There was significant N-cadherin and Erb-B4 peptide heterogeneity among the different PSEN mutations.

Conclusion
These observations imply that missense mutations in PSEN genes can alter a range of key γ-secretase activities to produce an array of subtly different biochemical, neuropathological and clinical manifestations. Beyond the broad common features of dementia, plaques and tangles, the various PSEN mutations resulted in a wide heterogeneity and complexity and differed from sporadic AD.
Cystoid macular oedema in Cogans syndrome-a case report
Authors: Pherwani Anupama , Bansal Shveta , Agrawal Shailesh , Gillow Timothy 
Published: November 2008

Abstract

Introduction
Cogan's Syndrome is typically characterised by a non syphilitic interstitial keratitis (IK), with or without conjunctivitis, iritis or subconjunctival bleeding and progressive sensorineural hearing loss within two years of ocular signs. Atypical ocular manifestations include episcleritis, scleritis, posterior scleritis, retinal artery occlusion, choroiditis, retinal vasculitis, and optic disc oedema. We report a case of Cogan's syndrome in with recurrent cystoid macular oedema was the main feature.

Case presentation
A patient was diagnosed with Cogan's syndrome nearly 2 years after first presentation. He had cystoid macular edema which failed to respond initially to steroid, methotrexate and azothiaprine however resolved after treatment with mycophenolate mofetil.

Conclusion
Cogan's syndrome is rare and presents a challenge in terms of diagnosis and treatment. Recurrent cystoid macular oedema is a unique finding in this condition and can be difficult to control. Multidisciplinary management of this multisystem disorder is vital.
Finite-element analysis of layered rolling contacts
Authors: Nikas G K , Sayles R S 
Published: November 2008

A fundamental, two-dimensional finite-element analysis (FEA) of coated surfaces in rolling contact is presented with detailed listing of all modelling steps. A large number of basic results from a parametric study has been derived, focusing on the stress analysis and the effect of coatings on the life expectancy of coated surfaces, without actually getting into the ambiguities of fatigue life evaluation. Parameters included in the study are the metallic coating thickness (from zero to 50 μm) and elastic modulus (from 180 to 240 GPa), the Coulomb friction coefficient (0, 0.05, and 0.10) and the endurance limit of the coated substrate. A generalization involves the application of traction to simulate driving or driven wheels. The effect of that traction on the stress results is thoroughly examined. The set of results, summarized in a figure with nine diagrams, assists the quick selection of the optimum parameter values for maximizing coating performance and minimizing the risk of contact fatigue within the design limits used in the study. The model is realistic in that it does not use idealized load distributions in the rolling contact but actual geometrical solids in contact under normal operating conditions, letting the FEA software resolve the loads and stresses, which are subsequently validated.
The influence of roller burnishing process on hardness and roughness of cylindrical polymer surfaces
Authors: El-Tayeb N S M , Low K O , Brevern P V 
Published: November 2008

In the present study, the potential for using the roller burnishing process to improve surface roughness and hardness of thermoplastics (acetal homopolymer, POM-H) and thermosets (polyurethane, PU) is investigated. The effect of roller burnishing parameters such as burnishing force, speed, feed, and roller width contact is studied. The results showed that all burnishing parameters had a controlling effect on surface roughness and hardness of POM-H and PU, but with different degrees. The effect of the roller burnishing process was more pronounced on POM-H compared with PU. Depending on the burnishing parameters, the surface roughness of POM-H and PU was decreased by ∼(32–37) and (28–32) per cent, respectively. Meanwhile, the hardness was marginally increased, i.e. by ∼0.8 and 1 per cent for POM-H and PU, respectively.