bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clear cell sarcoma of tendons and aponeuroses
Authors: Kawai Akira , Hosono Ako , Nakayama Robert , Matsumine Akihiko , Matsumoto Seiichi , Ueda Takafumi , Tsuchiya Hiroyuki , Beppu Yasuo , Morioka Hideo , Yabe Hiroo ,   for the Japanese Musculoskeletal Oncology Group
Published: November 2006

AbstractBACKGROUND.Clear cell sarcoma (CCS) of tendons and aponeuroses (malignant melanoma of soft parts) is a rare melanocytic soft tissue sarcoma. The objective of this study was to determine the clinical features, prognostic factors, and optimal treatment policy for patients with this rare disease.METHODS.Seventy‐five consecutive patients with histologically confirmed CCS who received treatment between 1980 and 2004 were analyzed retrospectively.RESULTS.There were 41 men and 34 women, and the median age was 36 years. Sixty‐five tumors were located in the extremities, and 10 tumors were located in the trunk. The median tumor size was 4 cm. Seventy‐one patients underwent surgical excision, and 56 patients received chemotherapy. Sixteen patients developed local recurrences, and 52 patients developed metastasis. The overall patient survival rates was 47% at 5 years and 36% at 10 years. Univariate analysis showed that sex (P= .018), tumor size (P= .001), tumor depth (P= .002), TNM classification (P= .001), and surgical margin (P= .042) were significant prognostic factors. Among the 52 patients who presented with localized disease, sex (P= .023), tumor size (P= .002), tumor depth (P= .011), TNM classification (P= .004), and chemotherapy (P= .032) were identified as significant prognostic factors. Multivariate analysis showed that tumor size remained an independent prognostic factor in both groups.CONCLUSIONS.The current results supported the contention that early diagnosis and initial wide excision are essential for a favorable outcome of CCS. The role of chemotherapy for CCS should be investigated further. Cancer 2007. © 2006 American Cancer Society.
Prognostic factors and outcome of recurrence in childhood acute myeloid leukemia
Authors: Rubnitz Jeffrey E. , Razzouk Bassem I. , Lensing Shelly , Pounds Stanley , Pui Ching‐Hon , Ribeiro Raul C. 
Published: November 2006

AbstractBACKGROUND.Outcome after recurrence of childhood acute myeloid leukemia (AML) is poor. We performed this study to identify prognostic factors for recurrence and for survival after recurrence of AML.METHODS.The clinical characteristics, biological features, treatment modalities, and outcomes of children with de novo AML who were enrolled on 3 consecutive clinical protocols from 1987 to 2002 at St. Jude Children's Research Hospital were studied. Regression modeling was used to identify prognostic factors for recurrence and for survival after recurrence.RESULTS.The outcome after recurrence was poor, with a 5‐year survival estimate of only 23.3% ± 5.7%. Multivariable analysis indicated that male sex (P= .005), autologous stem cell transplant before recurrence (P= .097), each additional month from diagnosis to recurrence (P= .041), and stem cell transplant after recurrence (P< .001) were associated with a better survival after recurrence, whereas M5 or M7 morphology (P= .001) were significantly predictive of a lower survival estimate after recurrence.CONCLUSIONS.Survival after recurrence was poor in children with AML. Novel therapies are urgently needed to prevent or to treat recurring AML. Cancer 2007. © 2006 American Cancer Society.
Granulocyte– and monocyte–platelet adhesion index in coronary and peripheral blood after extracorporeal circulation and reperfusion
Authors: Sbrana Silverio , Buffa Manuela , Bevilacqua Stefano , Spiller Dario , Parri Maria Serena , Gianetti Jacopo , De Filippis Rossella , Clerico Aldo 
Published: November 2006

AbstractBackground:Neutrophil‐granulocyte and mononuclear‐cell functional changes occur during cardiopulmonary bypass and cardiovascular surgery. In particular, leukocyte–platelet interaction, leading to generation of heterotypic coaggregates, represents an amplification mechanism of the local inflammatory response and tissue damage.Methods:Samples of 20 patients were drawn from venous coronary sinus before cardioplegic arrest and immediately after reperfusion, as well as from peripheral blood at 5 and 24 h postoperatively. The granulocyte and monocyte surface expression of CD162, CD15s, CD18, and CD11b were quantified by flow cytometry at the different times. Parallel variations of circulating leukocyte–platelet conjugates (percentages) and a derived (cell number‐normalized) leukocyte–platelet adhesion index were measured using a combination of antibodies against CD45, CD14, and CD41a. The evaluation of platelet functional state was carried out using antibodies against CD62P (P‐selectin) and PAC‐1.Results:Monocyte and granulocyte cell number increased markedly in coronary blood at reperfusion and in peripheral blood postoperatively when compared with measurements done before cardioplegia. A very different course characterized the changes of the leukocyte–platelet adhesion index with respect to the variations of circulating leukocyte–platelet coaggregates (percentages). Leukocyte molecules expression showed no significant variations for CD15s on both the leukocyte subsets, while a significant up‐modulation for CD162 was observed on monocytes at 24 h after extracorporeal circulation (P = 0.0002), and for CD11b on granulocytes at 5 h postoperatively (P = 0.033). A loss of CD162 expression was observed in coronary blood at reperfusion (P = 0.0038) on granulocytes, associated to a down‐modulation of CD18 (P = 0.0033) and CD11b (P = 0.0184) in peripheral blood at 24 h postoperatively. No significant up‐regulation of platelet activatory molecules expression was found at coronary reperfusion, as well as postoperatively in the peripheral blood, when compared with the before‐cardioplegia derived data.Conclusions:The over time variations of a normalized leukocyte–platelet adhesion index seem to reflect the cumulative leukocyte–platelet functional interaction more accurately than the parallel measurements of cellular conjugates. The absence of platelet activation suggests that the leukocyte membrane modifications play a main role in controlling the formation and stability of heterotypic leukocyte–platelet coaggregates after cardiac surgery with extracorporeal circulation. © 2006 International Society for Analytical Cytology
Reduced endothelin converting enzyme‐1 and endothelin‐3 mRNA in the developing bowel of male mice may increase expressivity and penetrance of Hirschsprung disease–like distal intestinal aganglionosis
Authors: Vohra Bhupinder P.S. , Planer William , Armon Jennifer , Fu Ming , Jain Sanjay , Heuckeroth Robert O. 
Published: November 2006

AbstractHirschsprung disease (distal intestinal aganglionosis, HSCR) is a multigenic disorder with incomplete penetrance, variable expressivity, and a strong male gender bias. Recent studies demonstrated that these genetic patterns arise because gene interactions determine whether enteric nervous system (ENS) precursors successfully proliferate and migrate into the distal bowel. We now demonstrate that male gender bias in the extent of distal intestinal aganglionosis occurs in mice with Ret dominant‐negative mutations (RetDN) that mimic human HSCR. We hypothesized that male gender bias could result from reduced expression of a gene already known to be essential for ENS development. Using quantitative real‐time polymerase chain reaction (PCR) we demonstrated reduced levels of endothelin converting enzyme‐1 and endothelin‐3 mRNA in the male mouse bowel at the time that ENS precursors migrate into the colon. Other HSCR‐associated genes are expressed at comparable levels in male and female mice. Testosterone and Mullerian inhibiting substance had no deleterious effect on ENS precursor development, but adding EDN3 peptide to E11.5 male RetDN heterozygous mouse gut explants in organ culture significantly increased the rate of ENS precursor migration through the bowel. Developmental Dynamics 236:106–117, 2007. © 2006 Wiley‐Liss, Inc.
A Ligand‐Driven Geometry Switch in Octahedral and Trigonal‐Bipyramidal Iron Complexes Containing (H)PNO and PNN Ligands
Authors: Pelagatti Paolo , Bacchi Alessia , Balordi Marcella , Caneschi Andrea , Giannetto Marco , Pelizzi Corrado , Gonsalvi Luca , Peruzzini Maurizio , Ugozzoli Franco 
Published: November 2006

AbstractComplexation reactions of FeII and FeIII salts with the tridentate ligands 2‐(diphenylphosphanyl)benzaldehyde benzoylhydrazone [(H)PNO] and N‐[2‐(diphenylphosphanyl)benzylidene]‐2‐(2‐pyridyl)ethanamine (PNN) was carried out. For (H)PNO, reaction of a stoichiometric amount of anhydrous FeCl2 in the presence of a primary alcohol such as MeOH, EtOH or nBuOH gave the mixed‐valence FeII/FeIII paramagnetic complex [Fe{κ3‐(H)PNO}2]Cl[FeCl4], whereas the reaction between FeCl2 and a twofold excess of (H)PNO in the presence of AgOTf (OTf = triflate, OSO2CF3) led to the isolation of the bis‐chelate paramagnetic ferrous complex [Fe{κ3‐(H)PNO}2][OTf]2. A diamagnetic bis‐chelate ferrous complex [Fe{κ3‐(PNO)2}] was instead obtained from the reaction of FeCl2 with a twofold excess of (H)PNO in the presence of NaOMe. In the case of the PNN ligand, the 1:1 reaction with FeCl2 gave the neutral paramagnetic trigonal‐bipyramidal complex [Fe(κ3‐PNN)Cl2]. The X‐ray structures of [Fe{κ3‐(H)PNO}2]Cl[FeCl4], [Fe2{κ3‐(H)PNO}2Cl6] and [Fe(κ3‐PNN)Cl2] are reported, together with CV and magnetic susceptibility measurements and an ab initio study aimed at rationalizing the different stoichiometries and structures observed with the two tridentate ligands. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
Tuning the Properties of Neutral Tetraazamacrocyclic Complexes of Copper(II) and Nickel(II) for Use as Host–Guest Compounds with Bismacrocyclic Transition Metal Cations
Authors: Rybka Anita , Koliński Ryszard , Kowalski Jarosław , Szmigielski Rafał , Domagała Sławomir , Woźniak Krzysztof , Więckowska Agnieszka , Bilewicz Renata , Korybut‐Daszkiewicz Bohdan 
Published: November 2006

AbstractThe synthesis and structural properties of tetraazamacrocyclic ligands and their neutral and protonated 14‐, 15‐ and 16‐membered complexes of CuII and NiII are described. Molecules of the free 14‐membered ligands have a nonplanar, step‐like structure of the central molecular fragments. Conformational changes are introduced upon protonation, with the protons pointing above and below the macrocycle plane. This prevents the formation of intramolecular N–H···N hydrogen bonds. On insertion of the transition metal ions a planar structure of the macrocycle is obtained, which has consequences for the electrochemical behaviour of the complexes. The deviations from planarity increase with increasing macrocycle size. As a consequence the donor properties are weaker, the redox potential is shifted towards more positive values and the contribution of chemical reactions can be observed. The formation of host–guest complexes between the strongest metal‐containing donors and transition‐metal‐containing bismacrocyclic acceptors of suitable size is proved in solution and the gas phase by voltammetric and ESI MS methods. The transition metal building blocks described in this contribution can be applied in the synthesis of new redox‐active rotaxane and catenane systems. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
Synthesis, Structures, and Electronic Spectroscopy of Luminescent Acetylene‐ and (Buta‐1,3‐diyne)platinum Complexes
Authors: Zhang Ke , Hu Jian , Chan Kwok Chu , Wong Kwok Yin , Yip John H. K. 
Published: November 2006

AbstractThe electronic absorption and emission spectroscopy of a series of diphenylaceylene‐ and (buta‐1,3‐diyne)‐Pt0 complexes (L)Pt[(1,2‐η2)‐R–(C≡C)n–R] and [(dppp)Pt]2[μ‐(1,2‐η2):(3,4‐η2)‐R–(C≡C)2–R] {R = Ph or CH3, L = dppp or(PPh3)2, n = 1 or 2} was investigated. The structures of(dppp)Pt[(1,2‐η2)‐Ph–C≡C–Ph], (dppp)Pt[(1,2‐η2)‐PhC4Ph] and [(dppp)Pt]2[μ‐(1,2‐η2):(3,4‐η2)‐Ph–(C≡C)2–Ph] were characterized by X‐ray diffraction. The complexes all display intense absorptions that were attributed to Pt→P(dπ*) and Pt→acetylene(πx*) transitions. Except for the CH3C4CH3 complexes, the complexes all exhibit two emissions at 380–550 nm and 500–800 nm. The higher energy emission could arise from the 3[P(dπ*)→Pt] transition, and the lower energy emission, which has a longer lifetime than the higher energy one, was attributed to the 3[acetylene(πx*)→Pt] transition. The energy of the MLCT absorption and emission was affected by the electronic properties of the acetylenes and the ancillary phosphanes. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
Regioselective Hydration and Deprotection of Chiral, Dissymmetric Iminodinitriles in the Scope of an Asymmetric Strecker Strategy
Authors: Rossi Jean‐Christophe , Marull Marc , Boiteau Laurent , Taillades Jacques 
Published: November 2006

AbstractThe controlled, selective decomposition of dissymmetric iminodinitriles (DIDN) of formula RCH(CN)–NH–C(CN)R′R″ (considered as N‐protected alpha‐aminonitriles), is a critical issue for an original asymmetric Strecker strategy previously outlined by us for the enantioselective synthesis of amino acids. This strategy, derived from Harada's work, involves a double sequence of (i) stereoselective Strecker condensation of a chiral ketone R′R″CO with NH3 and HCN, followed by (ii) stereoselective Strecker condensation with an aldehyde RCHO and HCN, then (iii) regioselective retro‐Strecker decomposition of the DIDN intermediate to release the target alpha‐aminonitrile. In addition to the use of quite simple, cheap cyclic ketones (e.g. carvone derivatives) as chiral auxiliaries, another great advantage of this strategy is that step (iii) enables the recovery of the chiral ketone and hence its reuse. While our previous investigations on step (iii) under various conditions, either preceded or followed by the hydration of the secondary nitrile group RH(CN)‐ into an amide, had shown insufficient selectivity, we succeeded in the regioselective hydration of the secondary nitrile of DIDN without significant racemisation, by using a large excess of hydrogen peroxide in methanolic/aqueous ammonia (pH 12.5) at low temperature. The resulting imino nitrile/amide compound was then classically decomposed in acidic medium through a retro‐Strecker reaction, affording the chiral alpha‐amino amide. Alternately, the regioselective retro‐Strecker decomposition of the tertiary moiety of the DIDN was achieved by reaction with silver cation in aqueous nitric acid, also without significant racemisation, thus establishing an original, enantioselective synthesis of alpha‐aminonitriles. In both reactions, the chiral ketonic auxiliary resulting from DIDN decomposition was recovered in good yields. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
In the Search of Glycogen Phosphorylase Inhibitors: Synthesis of C‐D‐Glycopyranosylbenzo(hydro)quinones – Inhibition of and Binding to Glycogen Phosphorylase in the Crystal
Authors: He Li , Zhi Zhang Yun , Tanoh Marcelle , Chen Guo‐Rong , Praly Jean‐Pierre , Chrysina Evangelia D. , Tiraidis Costas , Kosmopoulou Magda , Leonidas Demetres D. , Oikonomakos Nikos G. 
Published: November 2006

AbstractPenta‐O‐acetyl‐β‐D‐glycopyranoses and 1,4‐dimethoxybenzene led selectively by electrophilic substitution to C‐β‐D‐glycopyranosyl‐1,4‐dimethoxybenzenes which were converted by simple and efficient reactions (oxidation, reduction and deacetylation) to the corresponding C‐glycosylhydro‐ and C‐glycosylbenzoquinones, with either an acetylated or deprotected sugar moiety. C‐β‐D‐Glucosylbenzoquinone 19 and C‐β‐D‐Glucosylhydroquinone 23 were found to be competitive inhibitors of rabbit muscle glycogen phosphorylase b (GPb), with respect to the substrate α‐D‐glucose‐1‐phosphate, with Ki values of 1.3 and 0.9 mM, respectively, whereas C‐β‐D‐glucosylhydroquinone 17 was not effective up to a concentration of 8 mM. In order to elucidate the structural basis of inhibition, we determined the crystal structures of 19 and 23 in complex with GPb at a 2.03–2.05 Å resolution. The complex structures reveal that the inhibitors can be accommodated at the catalytic site at approximately the same position as α‐D‐glucose and stabilise the transition state conformation of the 280s loop by making several favourable contacts to Asp283 and Asn284 of this loop. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
Solid‐Phase Synthesis of Acid‐Sensitive N‐(2‐Aminoethyl)glycine‐PNA Oligomers by the Fmoc/Bhoc Strategy
Authors: Stafforst Thorsten , Diederichsen Ulf 
Published: November 2006

AbstractIn the context of investigation of nucleic acid‐mediated excess electron transfer, a bis‐functionalized (2‐aminoethyl)glycine‐PNA modified with a flavin and an oxetane moiety was synthesized. The solid‐phase synthesis of the required PNA oligomer was especially intriguing because of the high acid sensitivity of the oxetane moiety, so the Fmoc/Bhoc strategy was adapted to the mild cleavage conditions of the Sieberamide resin. Along with smooth oligomerization conditions, the syntheses of oxetane‐ and flavin‐functionalized Fmoc‐protected (2‐aminoethyl)glycine building blocks are reported. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
Carbon dioxide capture by indirect thermal swing adsorption using 13X zeolite
Authors: Mérel J. , Clausse M. , Meunier F. 
Published: November 2006

AbstractThe aim of this article is to investigate the performances of an indirect temperature swing adsorption process for CO2 removal from nitrogen using 13X zeolite. Breakthrough experiment, with a 10% CO2–N2 mixture, were performed showing that thanks to the cooling, the adsorbent capacity is preserved and close to that of an isothermal adsorption. For the desorption step, CO2 at a concentration of nearly 100% is recovered thanks to the indirect heating and the non‐use of purge gas. During the cycle experiments, we obtained 7.9 MJ/kg for the specific heat consumption. This value is slightly higher than amine absorption ones, which is the reference process for CO2 capture. However, it has to be taken into account that there is a good potential of energy saving because our process configuration (adsorbent choice, number of beds, step duration, etc.) has not been optimized yet. Moreover, in scaled‐up process, the heat losses are of less importance, which will decrease the specific heat consumption. This is confirmed by a first estimation, which gives a value of 5.9 MJ/kg. © 2006 American Institute of Chemical Engineers Environ Prog, 25: 327–333, 2006
Ceramic Supported Capillary Pd Membranes for Hydrogen Separation: Potential and Present Limitations
Authors: Gepert V. , Kilgus M. , Schiestel T. , Brunner H. , Eigenberger G. , Merten C. 
Published: November 2006

AbstractComposite ceramic capillaries coated with thin palladium membranes are developed for the production of CO‐free hydrogen for PEM fuel cells, via alcohol steam reforming. The composite membranes are tested for pure H2 and N2, as well as for synthetic reformate gas. The aim is to develop a heat‐integrated compact membrane reformer for decentralized hydrogen production. In this context, a deep knowledge of the performance, behavior, and necessary treatment of the composite palladium membranes plays a decisive role in process design. The current contribution focuses on the main hurdles met while attempting to exploit the potential of ceramic supported capillary palladium membranes.
PLP overexpression perturbs myelin protein composition and myelination in a mouse model of Pelizaeus‐Merzbacher disease
Authors: Karim Saadia A. , Barrie Jennifer A. , McCulloch Mailis C. , Montague Paul , Edgar Julia M. , Kirkham Douglas , Anderson Thomas J. , Nave Klaus A. , Griffiths Ian R. , Mclaughlin Mark 
Published: November 2006

AbstractDuplication of PLP1, an X‐linked gene encoding the major myelin membrane protein of the human CNS, is the most frequent cause of Pelizaeus‐Merzbacher disease (PMD). Transgenic mice with extra copies of the wild type Plp1 gene, a valid model of PMD, also develop a dysmyelinating phenotype dependant on gene dosage. In this study we have examined the effect of increasing Plp1 gene dosage on levels of PLP/DM20 and on other representative myelin proteins. In cultured oligodendrocytes and early myelinating oligodendrocytes in vivo, increased gene dosage leads to elevated levels of PLP/DM20 in the cell body. During myelination, small increases in Plp1 gene dosage (mice hemizygous for the transgene) elevate the level of PLP/DM20 in oligodendrocyte soma but cause only minimal and transient effects on the protein composition and structure of myelin suggesting that cells can regulate the incorporation of proteins into myelin. However, larger increases in dosage (mice homozygous for the transgene) are not well tolerated, leading to hypomyelination and alteration in the cellular distribution of PLP/DM20. A disproportionate amount of PLP/DM20 is retained in the cell soma, probably in autophagic vacuoles and lysosomes whereas the level in myelin is reduced. Increased Plp1 gene dosage affects other myelin proteins, particularly MBP, which is transitorily reduced in hemizygous mice but consistently and markedly lower in homozygotes in both myelin and naïve or early myelinating oligodendrocytes. Whether the reduced MBP is implicated in the pathogenesis of dysmyelination is yet to be established. © 2006 Wiley‐Liss, Inc.
Abnormal activation of the social brain during face perception in autism
Authors: Hadjikhani Nouchine , Joseph Robert M. , Snyder Josh , Tager‐Flusberg Helen 
Published: November 2006

AbstractASD involves a fundamental impairment in processing social‐communicative information from faces. Several recent studies have challenged earlier findings that individuals with autism spectrum disorder (ASD) have no activation of the fusiform gyrus (fusiform face area, FFA) when viewing faces. In this study, we examined activation to faces in the broader network of face‐processing modules that comprise what is known as the social brain. Using 3T functional resonance imaging, we measured BOLD signal changes in 10 ASD subjects and 7 healthy controls passively viewing nonemotional faces. We replicated our original findings of significant activation of face identity‐processing areas (FFA and inferior occipital gyrus, IOG) in ASD. However, in addition, we identified hypoactivation in a more widely distributed network of brain areas involved in face processing [including the right amygdala, inferior frontal cortex (IFC), superior temporal sulcus (STS), and face‐related somatosensory and premotor cortex]. In ASD, we found functional correlations between a subgroup of areas in the social brain that belong to the mirror neuron system (IFC, STS) and other face‐processing areas. The severity of the social symptoms measured by the Autism Diagnostic Observation Schedule was correlated with the right IFC cortical thickness and with functional activation in that area. When viewing faces, adults with ASD show atypical patterns of activation in regions forming the broader face‐processing network and social brain, outside the core FFA and IOG regions. These patterns suggest that areas belonging to the mirror neuron system are involved in the face‐processing disturbances in ASD. Hum Brain Mapp, 2007. © 2006 Wiley‐Liss, Inc.