bluuebunny/crossref_metadata_2025_split huggingface dataset:
The feasibility and clinical significance of lateral approach thyroidectomy
Authors: An Ran , Gu Yong-Xue , Ni Xi-Hao , Lei Ying , Wang Wei-Tao , Men Xiao-Juan , Ma Jing-Yi , Wang Chang-Liang 
Published: March 2024

BackgroundBy comparing the three lateral approaches to thyroidectomy, the feasibility and clinical effects were analyzed, and the advantages of the lateral approach were summarized.MethodsFrom January 2022 to January 2023, 52 patients with thyroid cancer admitted to our department were selected and subjected to Lateral approach for thyroidectomy. Among them, 31 patients underwent thyroidectomy via the supraclavicular approach, 13 patients underwent endoscopic thyroidectomy via the subclavicular approach, and 8 patients underwent endoscopic thyroidectomy via the axillary approach. The basic conditions, surgical conditions, complications, postoperative pain scores and postoperative satisfaction of patients in the three approach surgery groups were recorded and analyzed.ResultsThere were no significant differences among the three approach groups in terms of patient characteristics, number of central lymph node dissections, intraoperative blood loss, postoperative drainage volume, duration of drainage tube placement, length of hospital stay, postoperative pain, satisfaction, and complications. However, the operation time was longest in the subclavicular approach group, followed by the axillary approach group, and shortest in the supraclavicular approach group. The total hospitalization cost was highest in the axillary approach group, followed by the subclavicular approach group, and lowest in the supraclavicular approach group.ConclusionThe lateral approach for thyroidectomy is deemed a safe and effective method. The three different approach paths gradually increase in length, allowing for the accumulation of anatomical experience. This approach has a shorter learning curve for clinical doctors and is a favorable choice for patients seeking aesthetic benefits.
Prevalence of fatigue and cognitive impairment after traumatic brain injury
Authors: Wright Traver J. , Elliott Timothy R. , Randolph Kathleen M. , Pyles Richard B. , Masel Brent E. , Urban Randall J. , Sheffield-Moore Melinda 
Published: March 2024

Background
Following traumatic brain injury (TBI) some patients develop lingering comorbid symptoms of fatigue and cognitive impairment. The mild cognitive impairment self-reported by patients is often not detected with neurocognitive tests making it difficult to determine how common and severe these symptoms are in individuals with a history of TBI. This study was conducted to determine the relative prevalence of fatigue and cognitive impairment in individuals with a history of TBI.

Methods
The Fatigue and Altered Cognition Scale (FACs) digital questionnaire was used to assess self-reported fatigue and cognitive impairment. Adults aged 18–70 were digitally recruited for the online anonymous study. Eligible participants provided online consent, demographic data, information about lifetime TBI history, and completed the 20 item FACs questionnaire.

Results
A total of 519 qualifying participants completed the online digital study which included 204 participants with a history of TBI of varied cause and severity and 315 with no history of TBI. FACs Total Score was significantly higher in the TBI group (57.7 ± 22.2) compared to non-TBI (39.5 ± 23.9; p<0.0001) indicating more fatigue and cognitive impairment. When stratified by TBI severity, FACs score was significantly higher for all severity including mild (53.9 ± 21.9, p<0.0001), moderate (54.8 ± 24.4, p<0.0001), and severe (59.7 ± 20.9, p<0.0001) TBI. Correlation analysis indicated that more severe TBI was associated with greater symptom severity (p<0.0001, r = 0.3165). Ancillary analysis also suggested that FACs scores may be elevated in participants with prior COVID-19 infection but no history of TBI.

Conclusions
Adults with a history of even mild TBI report significantly greater fatigue and cognitive impairment than those with no history of TBI, and symptoms are more profound with greater TBI severity.
Taste dysfunction as a predictor of depression in schizophrenia: A systematic review and meta-analysis
Authors: Liu Jia , Sun Shu-Jie , Lu Ye , Ping Xin , Zhang Wan , Pei Lin 
Published: March 2024

Objective
This study aims to investigate the relationship between taste dysfunction and depression among patients with schizophrenia, to achieve early detection of depression in clinical practice.

Methods
Following PRISMA guidance, a comprehensive literature search was conducted globally, covering papers published from 1961 to June 2023. A total of 17 manuscripts were selected through meta-analysis and sensitivity analysis after examining available materials from seven databases to determine the correlation between depression and taste dysfunction.

Results
The comparison of the 17 selected manuscripts revealed that individuals with gustatory dysfunction may be more likely to experience depressive symptoms (SMD, 0.51, 95% CI, 0.08 to 0.93, p = 0.02). Depression is associated with taste dysfunction in certain aspects, as indicated by the pleasantness ratings of sucrose solutions (SMD, -0.53, 95% confidence interval [CI] -1.11 to 0.05, p = 0.08), gustatory identification ability (SMD, 0.96, 95% CI, 0.03 to 1.89, p = 0.04), and the perception threshold of sweet taste (MD, 0.80, 95% CI, 0.79 to 0.81, p < 0.00001).

Conclusions
Due to variations in the methods, designs, and selection criteria employed in the included studies, it is necessary to establish a feasible framework. Future research using detailed and targeted approaches can provide clearer and more unified conclusions on the relationship between taste dysfunction and depression. Moreover, further high-quality research is needed to obtain clearer conclusions and explore the potential of taste dysfunction as an effective tool for early screening of depression.

Trial registration
This review has been registered in the PROSPERO on April 2022 with the identifier CRD42023400172.
Single-cell analysis reveals landscape of endometrial cancer response to estrogen and identification of early diagnostic markers
Authors: Dong Chunli , Zhao Liyan , Liu Xiongtao , Dang Ling , Zhang Xin 
Published: March 2024

Background
The development of endometrial cancer (EC) is closely related to the abnormal activation of the estrogen signaling pathway. Effective diagnostic markers are important for the early detection and treatment of EC.

Method
We downloaded single-cell RNA sequencing (scRNA-seq) and spatial transcriptome (ST) data of EC from public databases. Enrichment scores were calculated for EC cell subpopulations using the “AddModuleScore” function and the AUCell package, respectively. Six predictive models were constructed, including logistic regression (LR), Gaussian naive Bayes (GaussianNB), k-nearest neighbor (KNN), support vector machine (SVM), extreme gradient boosting (XGB), and neural network (NK). Subsequently, receiver-operating characteristics with areas under the curves (AUCs) were used to assess the robustness of the predictive model.

Result
We classified EC cell coaggregation into six cell clusters, of which the epithelial, fibroblast and endothelial cell clusters had higher estrogen signaling pathway activity. We founded the epithelial cell subtype Epi cluster1, the fibroblast cell subtype Fib cluster3, and the endothelial cell subtype Endo cluster3 all showed early activation levels of estrogen response. Based on EC cell subtypes, estrogen-responsive early genes, and genes encoding Stage I and para-cancer differentially expressed proteins in EC patients, a total of 24 early diagnostic markers were identified. The AUCs values of all six classifiers were higher than 0.95, which indicates that the early diagnostic markers we screened have superior robustness across different classification algorithms.

Conclusion
Our study elucidates the potential biological mechanism of EC response to estrogen at single-cell resolution, which provides a new direction for early diagnosis of EC.
Chronic Hepatitis E Virus Manifesting as Elevated Transaminases in a Heart Transplant Patient
Authors: Mohamed Islam , Sanders Kimberly , Hillebrand Donald J. 
Published: March 2024

ABSTRACT
Hepatitis E virus (HEV) is a common cause of viral hepatitis worldwide. Genotypes 1 and 2 cause acute hepatitis in endemic regions (Asia and Africa), whereas genotypes 3 and 4 (America and Europe) result in sporadic acute or chronic hepatitis, specifically in certain groups. HEV infections are rising because of increased transplantation rates and immunosuppression. We report a 75-year-old heart transplant patient with nonspecific symptoms, diagnosed with HEV chronic hepatitis. Despite ribavirin-induced hemolytic anemia, the patient achieved sustained virological response and normalization of liver enzymes.
Pancreatic Tuberculosis With Duodenal Fistula Presenting as Life-Threatening Gastrointestinal Bleeding
Authors: Zaffar Duha , Ranabhat Chet Bahadur , Ismail Abdellatif , Gogna Gurdeep , Hossain Sarah , Rodriguez Gracia Viana , Sharma Disha , Kim Raymond E. 
Published: March 2024

ABSTRACT
Pancreatic tuberculosis (TB) warrants heightened suspicion in individuals with pancreatic lesions and risk factors such as HIV, organ transplantation, or pertinent immigration history. We present a 38-year-old man who presented with hemodynamically unstable gastrointestinal bleeding. He was found to have pancreatic TB complicated by a duodenal ulcer with fistula. Following 1 month of antitubercular therapy, he experienced complete resolution of symptoms, healing of the duodenal ulcer, closure of the fistulous tract, and a decrease in the size of the pancreatic lesion as observed on imaging. Our case highlights the importance of early diagnosis and treatment of pancreatic TB.
Microangiopatía trombótica (MAT) asociada al embarazo: papel del laboratorio clínico en el diagnóstico diferencial
Authors: Ramos Mayordomo Patricia , Capilla Díez Marta , Ticona Espinoza Danay Areli , Torres Jaramillo María Verónica , Martínez Tejeda Nathalie , Ticona Espinoza Thalia Gloria , Colmenero Calleja Cristina , Fraile Gutiérrez Virginia 
Published: March 2024

Resumen

Objetivos
La microangiopatía trombótica (MAT) se define por trombocitopenia, anemia hemolítica microangiopática y daño de órganos diana. El embarazo está asociado con varias formas de MAT como preeclampsia (PE), síndrome de HELLP, púrpura trombótica trombocitopénica (PTT) y síndrome hemolítico urémico (SHU). Cuando SHU se produce por desregulación de la vía alternativa del complemento se denomina SHU atípico (SHUa). El diagnóstico diferencial es complejo, ya que comparten características clínicas, siendo importante realizarlo precozmente para instaurar tratamiento específico y mejorar el pronóstico.

Caso clínico
Primigesta de 43 años ingresa a la edad gestacional de 33 semanas, con diagnóstico de preeclampsia grave y sufrimiento fetal por lo que se realiza cesárea urgente. En el puerperio inmediato, presenta insuficiencia hepática aguda y fracaso renal anúrico en contexto de síndrome de HELLP, anemia, trombopenia, hipertensión arterial (HTA) y alteraciones neurológicas. Se realiza estudio de MAT y diagnóstico diferencial evidenciando además SHUa asociado al embarazo. Se inicia tratamiento con Eculizumab presentando buena respuesta y progresiva mejoría clínica y analítica.

Conclusiones
El SHUa es una enfermedad rara y multifactorial con elevada mortalidad antes de la aparición del Eculizumab. Debido al complejo diagnóstico, el laboratorio clínico tiene un papel clave en el diagnóstico diferencial y abordaje.
Assessing the Revised Safer Dx Instrument® in the understanding of ambulatory system design changes for type 1 diabetes and autism spectrum disorder in pediatrics
Authors: Brady Patrick W. , Ruddy Richard M. , Ehrhardt Jennifer , Corathers Sarah D. , Kirkendall Eric S. , Walsh Kathleen E. 
Published: March 2024

Abstract

Objectives
We sought within an ambulatory safety study to understand if the Revised Safer Dx instrument may be helpful in identification of diagnostic missed opportunities in care of children with type 1 diabetes (T1D) and autism spectrum disorder (ASD).

Methods
We reviewed two months of emergency department (ED) encounters for all patients at our tertiary care site with T1D and a sample of such encounters for patients with ASD over a 15-month period, and their pre-visit communication methods to better understand opportunities to improve diagnosis. We applied the Revised Safer Dx instrument to each diagnostic journey. We chose potentially preventable ED visits for hyperglycemia, diabetic ketoacidosis, and behavioral crises, and reviewed electronic health record data over the prior three months related to the illness that resulted in the ED visit.

Results
We identified 63 T1D and 27 ASD ED visits. Using the Revised Safer Dx instrument, we did not identify any potentially missed opportunities to improve diagnosis in T1D. We found two potential missed opportunities (Safer Dx overall score of 5) in ASD, related to potential for ambulatory medical management to be improved. Over this period, 40 % of T1D and 52 % of ASD patients used communication prior to the ED visit.

Conclusions
Using the Revised Safer Dx instrument, we uncommonly identified missed opportunities to improve diagnosis in patients who presented to the ED with potentially preventable complications of their chronic diseases. Future researchers should consider prospectively collected data as well as development or adaptation of tools like the Safer Dx.
Fetal protective effect of Indonesian propolis from Apis mellifera against rifampicin-pyrazinamide induced impaired pregnancy in BALB/c mice
Authors: Abdillah Rahmad , Rachmaini Fitri , Fadhilah Dinda , Almahdy Almahdy 
Published: March 2024

Abstract

Objectives
Anti-tuberculosis drugs rifampicin and pyrazinamide combination in pregnancy can cause morphological, visceral and skeletal damage. Several studies showed that propolis improves pregnancy outcomes. This study aims to determine the fetal protective effect of propolis in BALB/c mice given the anti-tuberculosis drug combination rifampicin and pyrazinamide.

Methods
A total of 21 pregnant mice were randomly divided into three groups: the normal group (N) was given distilled water as a vehicle, the positive control group (RP) were given rifampicin 15 mg/kg BW, pyrazinamide 35 mg/kg BW and the treatment group (IP) were given rifampicin 15 mg/kg BB, pyrazinamide 35 mg/kg BW and propolis 400 mg/kg BW. The treatment was given during the period of organogenesis, from day 6 to day 15. Laparotomy was performed on the 18th day of pregnancy. Maternal and fetal body weight, fetal length, number of fetuses, and skeletal defects of fetuses were used as parameters to identify the teratogenic effect. All data were analyzed using the ANOVA.

Results
All groups significantly differed between maternal and fetal body weights (p<0.05). The administration of rifampicin-pyrazinamide and propolis during pregnancy did not significantly affect the number of fetuses (p>0.05). The administration of propolis protects the fetus from skeletal abnormalities. While in the RP and IP groups, we can find resorption sites and haemorrhagic.

Conclusions
This study may suggest the protective effects of propolis against rifampicin pyrazinamide-induced impaired pregnancy.
Simulating VLBI observations to BeiDou and Galileo satellites in L-band for frame ties
Authors: Schunck David , McCallum Lucia , Calves Guifre Molera 
Published: March 2024

Abstract
Using the very long baseline interferometry (VLBI) technique to observe Earth-orbiting satellites is a topic of increasing interest for the establishment of frame ties. We present a simulation study on VLBI observations to BeiDou and Galileo satellites in L-band to investigate the accuracy of inter-technique frame ties between VLBI and global navigation satellite system (GNSS). We employ a global network of 16 antennas equipped with dedicated L-band receivers capable of observing BeiDou’s B1 and B3 navigation signals and Galileo’s E1 and E6 navigation signals. Through extensive Monte Carlo simulations, we simulate 24-h sessions to determine the optimal ratio of satellite to quasar scans. The optimal schedule uses about 80–90% satellite sources. We find that the 10–20% observations of quasar sources improve the estimation of the troposphere and, consequently, the estimation of the antenna position. Combining the normal equations from seven 24-h sessions, we derive a 7-day solution. The average antenna position repeatability is 7.3 mm. We identify the limitations of the results as the tropospheric turbulence, inaccuracies in the satellite orbit determination, and the lack of a more homogeneously distributed global network. This simulation study supports the understanding in the topic of building a frame tie using VLBI observations to GNSS satellites.
Transfer learning for metamaterial design and simulation
Authors: Peng Rixi , Ren Simiao , Malof Jordan , Padilla Willie J. 
Published: March 2024

Abstract
We demonstrate transfer learning as a tool to improve the efficacy of training deep learning models based on residual neural networks (ResNets). Specifically, we examine its use for study of multi-scale electrically large metasurface arrays under open boundary conditions in electromagnetic metamaterials. Our aim is to assess the efficiency of transfer learning across a range of problem domains that vary in their resemblance to the original base problem for which the ResNet model was initially trained. We use a quasi-analytical discrete dipole approximation (DDA) method to simulate electrically large metasurface arrays to obtain ground truth data for training and testing of our deep neural network. Our approach can save significant time for examining novel metasurface designs by harnessing the power of transfer learning, as it effectively mitigates the pervasive data bottleneck issue commonly encountered in deep learning. We demonstrate that for the best case when the transfer task is sufficiently similar to the target task, a new task can be effectively trained using only a few data points yet still achieve a test mean absolute relative error of 3 % with a pre-trained neural network, realizing data reduction by a factor of 1000.
“The Beauty of Homes Beautiful Collectively”: The Olmsted Firm and the View from the Suburban House
Authors: Marine Nicolas 
Published: March 2024

Abstract
The landscape architects Frederick Law Olmsted and his sons John Charles and Frederick Jr. changed the prevailing understanding of the view from the suburban home. Historically, such vistas reflected a sense of isolation in nature, an experience that the early suburban communities of the nineteenth century attempted to replicate. In contrast, the elder Olmsted, in his first suburban design, posited the need for the neighborhood to be visible and distinguishable from the houses; it would form the foreground of views into more distant landscapes. This article examines the lineage of this vista and how Frederick Law Olmsted’s sons, through their firm Olmsted Brothers, later came to replicate it systematically in their suburban projects. A comparison with possible antecedents of this particular view shows that the Olmsteds not only made it a fundamental design factor but also endowed it with ethical and aesthetic qualities.
The Choreography of Bedhaya Gandakusuma Dance with Mangkunegaran Style: The Study of Movement Patterns
Authors: Sriyadi Sriyadi 
Published: March 2024

Movement patterns in Javanese dance works are formed from types of movement series constructed to become a unified whole. This series of movements is often called a motion motif, a motion range, or sekaran. A series of movements can be likened to a puzzle arranged in such a way as to form a unified whole. This article aims to describe the movement patterns of the Bedhaya Gandakusuma dance with Mangkunegaran style. This description is essential to know the construction of the movement pattern used. This research is a form of qualitative research with an ethnochoreological approach. Data collection techniques used are participant observation, interviews, and literature study. The results show that the construction of the Bedhaya Gandakusuma dance movement patterns consists of elements of gesture and movement that become the basic material in the arrangement of each series of movements. In the arrangement process, it is tied with a motif or a basic movement as a unifying thread. The basic movement is a series of ngenceng movements. It means that the series of ngenceng movements become the foundation in various variations of the series of movements used. The series of movements are connected by using transition movements (sendhi). The movement patterns construction of the Bedhaya Gandakusuma dance not only considers motifs, variations, and transitions but also considers repetition, climax, proportion, logical development, and unity. The purpose is to achieve wholeness to give vitality in conveying the meaning or essence being expressed.
Use of testosterone replacement therapy to treat long-COVID-related hypogonadism
Authors: Amodeo Alessandro , Persani Luca , Bonomi Marco , Cangiano Biagio 
Published: March 2024

Summary
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can impair pituitary–gonadal axis and a higher prevalence of hypogonadism in post-coronavirus disease 2019 (COVID-19) patients compared with the general population has been highlighted. Here we report the first case of a patient affected with a long-COVID syndrome leading to hypogonadism and treated with testosterone replacement therapy (TRT) and its effects on clinical and quality of life (QoL) outcomes. We encountered a 62-year-old man who had been diagnosed with hypogonadotropic hypogonadism about 2 months after recovery from COVID-19 underwent a complete physical examination, general and hormonal blood tests, and self-reported questionnaires administration before and after starting TRT. Following the TRT, both serum testosterone level and hypogonadism-related symptoms were improved, but poor effects occurred on general and neuropsychiatric symptoms and QoL. Therefore, hypogonadism does not appear to be the cause of neurocognitive symptoms, but rather a part of the long-COVID syndrome; as a consequence, starting TRT can improve the hypogonadism-related symptoms without clear benefits on general clinical condition and QoL, which are probably related to the long-COVID itself. Longer follow-up might clarify whether post-COVID hypogonadism is a transient condition that can revert as the patient recovers from long-COVID syndrome.

Learning points

Hypogonadism is more prevalent in post-COVID-19 patients compared with the general population.

In these patients, hypogonadism may be part of long-COVID syndrome, and it is still unclear whether it is a transient condition or a permanent impairment of gonadal function.

Testosterone replacement therapy has positive effects on hypogonadism-related clinic without clear benefits on general symptomatology and quality of life, which are more likely related to the long-COVID itself.
Acercamientos para una definición de novela neopolicial costarricense
Authors: Solano Moraga Sigrid , Camacho Arias Ariadne 
Published: March 2024

Mariposas negras para un asesino (2005) and El laberinto del verdugo (2010), by Jorge Méndez Limbrick, come close to the condition of a Costa Rican neo-detective novel, within the Central American neo-detective framework. The relationship of these novels with that genre will be analyzed. A series of qualities will be proposed, such as the construction of complete characters, the exposure of crude realism and the presence of the night as a transcendental element for the emergence of crime, as the basis of a genre that is beginning to be defined and spread in the Costa Rican narrative.