bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tumor Size Combined With CA-19 Level Improves Prediction of Survival of Patients With Pancreatic Adenocarcinoma Undergoing Perioperative Chemotherapy and Resection
Authors: Said Sayf A. , Perlmutter Breanna C. , Wehrle Chase J. , Chang Jenny , Hossain Mir Shanaz , Naffouje Samer , Joyce Daniel , Simon Robert , Walsh R. Matthew , Augustin Toms 
Published: March 2024

Background and Objective Five-year survival in pancreatic adenocarcinoma is less than 20%. While previous studies have postulated that a carbohydrate antigen 19-9 (CA19-9) threshold could predict outcome of resection, the role for CA19-9 in decision-making remains unclear. This study aims to assess whether CA19-9 levels combined with tumor size improve prediction of post-resection survival. Method A retrospective analysis was conducted on 109 patients with pancreatic adenocarcinoma who underwent perioperative chemotherapy followed by resection. The primary outcome of mortality was, divided into short (<1 year) or prolonged (>2 years). Univariate and multivariable analyses compared the tumor size-adjusted CA19-9 between the outcome groups. Results Twenty-seven (24.78%) and eighty-two (75.23%) patients were in the short survival and prolonged-survival groups, respectively. The mean CA19-9 was significantly greater in the short vs prolonged group ( P < .001). Analyzing CA19-9 level by tumor size, the association of high CA19-9 and short survival was significant for small (≤2 cm) and large tumor (>4 cm), but not for intermediate-size tumors (2-4 cm). Adjusting for preoperative variable did not change this association. Conclusion CA 19-9 in combination with tumor size better identifies patients with prolonged post-resection survival. This prediction is most accurate in patients with either small (≤2 cms) or large (>4 cms) tumors compared to intermediate-size tumors.
Practice Patterns of Pancreatic Surgery Within the Military
Authors: Liang Joy N. , Anklowitz Andrew J. , Livezey Jonathan B. , O’Hara Thomas A. , Aranda Marcos C. , Bandera Bradley 
Published: March 2024

Introduction Pancreatic surgery is technically challenging, with mortality rates at high-volume centers ranging from 0% to 5%. An inverse relationship between surgeon volume and perioperative mortality has been reported suggesting that patients benefit from experienced surgeons at high-volume centers. There is little published on the volume of pancreatic surgeries performed in military treatment facilities (MTF) and there is no centralization policy regarding pancreatic surgery. This study evaluates pancreatic procedures at MTFs. We hypothesize that a small group of MTFs perform most pancreatic procedures, including more complex pancreatic surgeries. Methods This is a retrospective review of de-identified data from MHS Mart (M2) from 2014 to 2020. The database contains patient data from all Defense Health Agency treatment facilities. Variables collected include number and types of pancreatic procedures performed and patient demographics. The primary endpoint was the number and type of surgery for each MTF. Results Twenty-six MTFs performed pancreatic surgeries from 2014 to 2020. There was a significant decrease in the number of cases from 2014 to 2020. Nine hospitals performed one surgery over eight years. The most common surgery was a distal pancreatectomy, followed by a pancreaticoduodenectomy. There was a decrease in the number of pancreaticoduodenectomies and distal pancreatectomies performed over this period. Conclusions Pancreatic surgery is being performed at few MTFs with a downward trajectory over time. Further studies would be needed to assess the impact on patient care regarding postoperative complications, barriers to timely patient care, and impact on readiness of military surgeons.
Effect of Fitness-To-Drive and Metacognition on Road Traffic Injury Among Older Taxi Drivers: Hierarchical Modeling
Authors: Laosee Orapin , Sritoomma Netchanok , Rattanapan Cheerawit , Wamontree Phanida 
Published: March 2024

Age-related cognitive and somatic motor skills changes have been linked to impaired driving abilities. Taxi drivers play an important role in providing public transportation services and security. This study aimed to examine the level of fitness-to-drive (FTD) and identify the predictors of self-reported traffic injury among the older taxi drivers. Taxi drivers 60 years and older in Bangkok and the metropolitan area were enrolled. Hierarchical regression models were carried out to examine the effects of demographics, FTD, and metacognition towards self-reported road traffic injury. Totally, 46.1% of the respondents were classified as at-risk drivers. Drivers with alcohol consumption and low risk perception toward road safety were more likely to experience road traffic injury. Regular assessment of physical and psychometric capacity among older taxi drivers could provide another empirical basis to improve public safety transport.
A Mixed-Methods, Multimedia Pilot Study to Investigate Sleep Irregularity Determinants Among Undergraduate Students
Authors: Marquardt Matthew , Pontis Sheila 
Published: March 2024

Purpose To pilot a novel approach investigating the interplay of social and institutional determinants influencing university undergraduate student sleep patterns. Design A two-part, three-phase mixed-methods approach. Setting A mid-size US university conducted in spring and fall 2020. Participants 191 undergraduate students (69 first-years, 43 second-years, 48 third-years, 31 fourth-years). Method For Part A, participants texted their activities and emotions in real time, producing a data-rich, weeklong diary of comprehensive activity logs, emoticons, multimedia submissions, and juxtapositions of ideal vs real schedules. Semi-structured contextual interviews were also conducted. For Part B, a one-time survey examined Part A insights across all class years. These diverse datasets were triangulated using thematic, comparative, and content analyses through MAXQDA software and visual mapping methods. Results Three preliminary themes were identified as encouraging an irregular sleep schedule: a prevailing academic ethos emphasizing busyness, time management challenges, and the rhythm of institutional schedules and deadlines. An overarching theme suggests that perceptions of peer sleep habits and academic prioritization above all else could be influential across factors. Conclusion This pilot study indicates that sleep regularity among undergraduates is potentially shaped by individual choices combined with broader institutional paradigms. While it is limited by its exploratory nature, timing, and small sample size, the results highlight the promise of this methodology for more extensive studies and suggest that future interventions should emphasize systemic changes that prioritize sleep.
Clinical activity, pharmacokinetics, and pharmacodynamics of oral hypomethylating agents for myelodysplastic syndromes/neoplasms and acute myeloid leukemia: A multidisciplinary review
Authors: Haumschild Ryan , Kennerly-Shah Julie , Barbarotta Lisa , Zeidan Amer M. 
Published: March 2024

Objective To review the pharmacokinetic (PK)–pharmacodynamic (PD) profiles, disease setting, dosing, and safety of oral and parenteral hypomethylating agents (HMAs) for the treatment of myelodysplastic syndromes/neoplasms (MDS) and acute myeloid leukemia (AML), and to provide a multidisciplinary perspective on treatment selection and educational needs relating to HMA use. Data Sources Clinical and real-world data for parenteral decitabine and azacitidine and two oral HMAs: decitabine–cedazuridine (DEC-C) for MDS and azacitidine (CC-486) for AML maintenance therapy. Data Summary Differences in the PK–PD profiles of oral and parenteral HMA formulations have implications for their potential toxicities and planned use. Oral DEC-C (decitabine 35 mg and cedazuridine 100 mg) has demonstrated equivalent systemic area under the concentration-time curve (AUC) exposure to a 5-day regimen of intravenous (IV) decitabine 20 mg/m2 and showed no significant difference in PD. The AUC equivalence of oral DEC-C and IV decitabine means that these regimens can be treated interchangeably (but must not be substituted within a cycle). Oral azacitidine has a distinct PK–PD profile versus IV or subcutaneous azacitidine, and the formulations are not bioequivalent or interchangeable owing to differences in plasma time-course kinetics and exposures. Clinical trials are ongoing to evaluate oral HMA combinations and novel oral HMAs, such as NTX-301 and ASTX030. Conclusions Treatment with oral HMAs has the potential to improve quality of life, treatment adherence, and disease outcomes versus parenteral HMAs. Better education of multidisciplinary teams on the factors affecting HMA treatment selection may help to improve treatment outcomes in patients with MDS or AML.
Representation of marginalised populations in digital surveillance for notifiable conditions in Australia: a systematic review
Authors: Dias-Karunaratne N , Whop L , Ward J , Vujovich-Dunn C , Amin J , Dakiniewich A , Dyda A 
Published: March 2024

Aim: This study aims to establish whether digital surveillance methods for notifiable diseases in Australia collect and report data in relation to marginalised populations. Methods: The literature was systematically reviewed to identify primary research studies published between January 2005 and July 2023. Studies were included if they described an Australian digital surveillance system for notifiable conditions. The results were synthesised with a focus on evaluating the collection and reporting of data in relation to marginalised populations. Results: A total of 13 articles reporting on seven surveillance systems were identified. Influenza and adverse events following immunisation were the two most common notifiable conditions monitored. A total of six surveillance systems encompassing 16 articles reported information on sub-populations. Of these, three surveillance systems (nine articles) included data on marginalised populations. Conclusion: The data collected or reported in relation to sub-groups that characterise diversity in terms of health care needs, access, and marginalised populations are minimal. It is recommended that a set of equity and reporting principles is established for the future creation and use of any digital surveillance system.
Mitigating Intensive Care Unit Noise: Design-Led Modeling Solutions, Calculated Acoustic Outcomes, and Cost Implications
Authors: Jonescu Emil E. , Farrel Benjamin , Ramanayaka Chamil Erik , White Christopher , Costanzo Giuseppe , Delaney Lori , Hahn Rebecca , Ferrier Janet , Litton Edward 
Published: March 2024

Objectives, Purpose, or Aim: The study aimed to decrease noise levels in the ICU, anticipated to have adverse effects on both patients and staff, by implementing enhancements in acoustic design. Background: Recognizing ICU noise as a significant disruptor of sleep and a potential hindrance to patient recovery, this study was conducted at a 40-bed ICU in Fiona Stanley Hospital in Perth, Australia. Methods: A comprehensive mixed-methods approach was employed, encompassing surveys, site analysis, and acoustic measurements. Survey data highlighted the importance of patient sleep quality, emphasizing the negative impact of noise on work performance, patient connection, and job satisfaction. Room acoustics analysis revealed noise levels ranging from 60 to 90 dB(A) in the presence of patients, surpassing sleep disruption criteria. Results: Utilizing an iterative 3D design modeling process, the study simulated significant acoustic treatment upgrades. The design integrated effective acoustic treatments within patient rooms, aiming to reduce noise levels and minimize transmission to adjacent areas. Rigorous evaluation using industry-standard acoustic software highlights the design’s efficacy in reducing noise transmission in particular. Additionally, cost implications were examined, comparing standard ICU construction with acoustically treated options for new construction and refurbishment projects. Conclusions: This study provides valuable insights into design-based solutions for addressing noise-related challenges in the ICU. While the focus is on improving the acoustic environment by reducing noise levels and minimizing transmission to adjacent areas. It is important to clarify that direct measurements of patient outcomes were not conducted. The potential impact of these solutions on health outcomes, particularly sleep quality, remains a crucial aspect for consideration.
Sizing Up General Practice Environments for Big-Bodied Patients: An Environmental Assessment of Three Facilities in Aotearoa New Zealand
Authors: Morgan Sonya , Mihlar Sheharazade , Wood Emily , McKinlay Eileen , Gibbs Helen , Parker George , Gray Lesley 
Published: March 2024

Objectives: This research describes the physical environments of and equipment in Aotearoa New Zealand (NZ) general practices in relation to available standards for big-bodied people (BBP) seeking healthcare. Background: The prevalence of BBP both in NZ and globally has increased over the last 30 years and is expected to increase further. As the first and most utilized point of contact for patients in NZ and many countries, it is essential that general practices provide suitable environments to cater for and meet the needs of big-bodied patients seeking healthcare. Methods: An exploratory study utilizing an environmental investigation was undertaken in three diverse general practices. Data collection consisted of direct observation and physical measurements of practice layout and equipment. Findings were compared to the existing guidelines or standards for the healthcare of BBP. Results: The analysis identified most environmental facets and equipment in all three general practices did not meet published guidelines for the care of BBP. Conclusions: In the global context of increasing and sustained prevalence of BBP, this exploratory study highlights it is crucial that general practices and similar community-based facilities review their physical environments and equipment and consider modifications to improve accessibility, inclusivity, and comfort for BBP.
The Lived Experience of Family Support Among Women During and After Childbirth in Jordan: A Phenomenological Study
Authors: Ababneh Amal MT. , Alrida Nour , Abu-Abbas Manar , Rayan Ahmad , Abu Sumaqa Yasmeen , Alhamory Sajeda , Al-Zu’bi Basheer 
Published: March 2024

Introduction Many studies highlight the importance of family support in enhancing the experience of childbirth among women. Objective This qualitative study aimed to describe the lived experience of family support from the perspective of women during and after childbirth in the Jordanian context Methods A qualitative descriptive phenomenological approach was used to explore the experiences of women's family support in the context of their childbirth experiences. A total of 11 Jordanian women participated in the study. Face-to-face semi-structured interviews were conducted to collect data. Results Four major themes emerged from the data describing family support provided to women during and after childbirth. These themes were family support during childbirth, family support in the postpartum period, importance of family support during and after childbirth, and challenges related to receiving family support. Supportive family members primarily included the husband, the woman's family, and the family-in-law, according to the traditions inherited in the Jordanian context and culture. Conclusion The study findings could help maternal health professionals screen pregnant women who are at risk of receiving low family support, contribute to developing effective interventions regarding family-centered care, and enhance the overall childbirth experience for women in Jordanian cultural contexts.
University Students’ Physical Activity: Perceived Barriers and Benefits to Physical Activity and Its Contributing Factors
Authors: Alkhawaldeh Abdullah , Abdalrahim Asem , ALBashtawy Mohammed , Ayed Ahmad , Al Omari Omar , ALBashtawy Sa’d , Suliman Mohammad , Oweidat Islam Ali , Khatatbeh Haitham , Alkhawaldeh Hasan , Dameery Khloud Al , Alsaraireh Mahmoud , Alhroub Nisser 
Published: March 2024

Introduction In general, undergraduate university students in the north of Jordan have a low level of physical activity. Objectives To examine the physical activity level, perceived barriers and benefits to physical activity, and the contributing factors among university students in north of Jordan. Methods A cross-sectional study design was used, and data was collected from 235 university students through a self-reported questionnaire. The International Physical Activity Questionnaire (IPAQ) was utilized to calculate the amount of physical activity, while the exercise benefits and barriers scale (EBBS) was used to measure the perceived benefits and barriers of physical activity. Results According to the findings, less than half of the students (48.1%) reported engaging in physical activity. Several factors were found to be significantly related to higher levels of physical activity, including being younger, single, having a normal body weight, and reporting excellent health status. Logistic regression analysis revealed that overweight (OR = −0.068, 95% CI 0.025–0.183) and obese (OR = −0.250, 95% CI 0.068–0.924) were less likely to be physically active, while those who rated their health as excellent had higher rates of physical activity (OR = 3.590, 95% CI 1.263–10.201). The students agreed most strongly with the perceived benefit item “Exercise improves the way my body looks,” while the perceived barrier item they identified most strongly with was “There are too few places for me to exercise.” Conclusion This study provides important data for health promotion programs aimed at supporting physical activity among university students.
Association of Disability Status and Type With Binge Drinking and Prescription Opioid Misuse Among Adults From a 3-State Sample
Authors: Adams Rachel Sayko , Corrigan John D. , Ritter Grant A. , Pringle Zoe A. , Zolotusky Galina , Blayney Rachel , Reif Sharon 
Published: March 2024

Background: Research examining at-risk substance use by disability status is limited, with little investigation into differences by disability type. We investigated binge drinking and prescription opioid misuse among adults with and without disabilities, and by type of disability, to inform need for assessment and intervention within these populations. Methods: Secondary analyses of adults who completed the disability, alcohol, and prescription opioid misuse items in the 2018 Ohio, Florida, or Nebraska Behavioral Risk Factor Surveillance System surveys (n = 28 341), the only states that included prescription opioid misuse in 2018. Self-reported disability status (yes/no) relied on 6 standardized questions assessing difficulties with: vision, hearing, mobility, cognition, self-care, and independent living (dichotomous, nonmutually exclusive, for each disability). Logistic regression models estimated the association of disability status and type with (1) past 30-day binge drinking and (2) past-year prescription opioid misuse. Additional models were restricted to separate subsamples of adults who: (a) currently drink, (b) received a past-year prescription opioid, and (c) did not receive a past-year prescription opioid. Results: One-third reported at least one disability, with mobility (19.5%), cognitive (11.5%), and hearing (10.2%) disability being the most common. Disability status was associated with lower odds of binge drinking (adjusted odds ratio [AOR] = 0.74, 95% confidence interval [CI] 0.68-0.80, P ≤ .01). However, among adults who currently drink, people with disabilities had higher odds of binge drinking (AOR = 1.11, 95% CI 1.01-1.22, P ≤ .05]. Disability was associated with higher odds of past-year prescription opioid misuse (AOR = 2.51, 95% CI 2.17-2.91, P ≤ .01). Conclusions: Adults with disabilities had higher odds of prescription opioid misuse, and among adults who currently drink, higher odds for binge drinking were observed. The magnitude of the association between disability status and prescription opioid misuse was particularly concerning. Providers should be trained to screen and treat for substance use problems for people with disabilities.
The mineralogy of the historical Mochalin Log REE deposit, South Urals, Russia. Part V. Zilbermintsite-(La), (CaLa5)(Fe3+Al3Fe2+)[Si2O7][SiO4]5O(OH)3, a new mineral with ET2 type structure and a definition of the radekškodaite group
Authors: Kasatkin Anatoly V. , Zubkova Natalia V. , Škoda Radek , Pekov Igor V. , Agakhanov Atali A. , Gurzhiy Vladislav V. , Ksenofontov Dmitriy A. , Belakovskiy Dmitriy I. , Kuznetsov Aleksey M. 
Published: March 2024

AbstractThe new mineral zilbermintsite-(La), ideally (CaLa5)(Fe3+Al3Fe2+)[Si2O7][SiO4]5O(OH)3, was found in a single polymineralic nodule from the Mochalin Log REE deposit, Chelyabinsk Oblast, South Urals, Russia. Zilbermintsite-(La) forms anhedral grains up to 0.65 × 0.20 mm at the contact of ferriperbøeite-(La), törnebohmite-(La) and ferriallanite-(Ce). Other associated minerals include bastnäsite-(La), biraite-(La), ferriallanite-(La), ferriperbøeite-(Ce), fluorbritholite-(Ce), monazite-(La), perbøeite-(La), percleveite-(Ce), percleveite-(La), perrierite-(Ce), perrierite-(La), thorianite, thorite and quartz. The new mineral is light brown, translucent in thin fragments with a vitreous lustre. It is brittle, with good {100} cleavage. Mohs hardness is ca. 6. Dcalc = 4.684 g cm–3. Optically, zilbermintsite-(La) is biaxial (+), α = 1.805(7), β = 1.812(7) and γ = 1.867(8) (589 nm); 2Vmeas = 40(15)° and 2Vcalc = 40°. The empirical formula based on O28(OH,F)3 apfu is (Ca0.94La2.56Ce2.18Nd0.20Pr0.10Th0.02)Σ6.00(Al2.96Fe3+0.90Fe2+0.64Mg0.34Mn0.13Ti0.03)Σ5.00Si7.00O28[(OH)2.42F0.58]. Zilbermintsite-(La) is monoclinic, P21/m; the unit-cell parameters are: a = 8.9605(5), b = 5.7295(2), c = 25.1033(13) Å, β = 116.616(7), V = 1152.21(12) Å3 and Z = 2. The crystal structure of zilbermintsite-(La) is solved from the single-crystal X-ray diffraction data [R = 0.0757 for 2857 unique reflections with I > 2σ(I)]. The new mineral is isotypic to radekškodaite-(La) and radekškodaite-(Ce) and together with them forms the newly defined radekškodaite group. All members of this group possess the ET2 type structure where one epidote-type module (E) regularly alternates with two törnebohmite-type modules (T). The new mineral honours Professor Veniamin A. Zilbermints (1887–1939) who was a pioneer of the study of the Mochalin Log deposit. The Levinson suffix-modifier -(La) indicates the predominance of La among rare-earth elements in the mineral.