bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mass Emigration and the Erosion of Liberal Democracy
Authors: Auer Daniel , Schaub Max 
Published: April 2024

Abstracts
In many regions of the world, liberal politics is on the retreat. This development is usually explained with reference to inherently political phenomena. We propose an alternative explanation, linking democratic backsliding to deep-reaching demographic change caused by mass emigration. We argue that because migrants tend to be more politically liberal, their departure, if quantitatively significant, can hurt liberal democracy. Empirically, we focus on Central and Eastern Europe (CEE). Since 2004, the region has lost about 9 percent of its population due to migration to Western Europe. Drawing on data from 430,000 individuals and a panel analysis, we show that CEE migrants systematically hold more liberal values than non-migrants and that their exit went along with a deterioration of democracy in their home countries. Further analyses show that the mechanism we describe generalizes to various other world regions. Mass emigration may pose a challenge to democratic development in migrant-sending countries around the globe.
Molecular identification and related functional characterization of the FKBP52 gene in immunity of Locusta migratoria manilensis (Orthoptera: Oedipodidae)
Authors: Wang Menghong , Tian Ye , Zhang Neng , Nong Xiangqun , Tu Xiongbing , Zhang Zehua , Huang Yaxi , Wang Yi , Zhuang Ling , Cha Gan , Liu Tinghui , Wang Guangjun 
Published: April 2024

Abstract
Metarhizium anisopliae is an important class of entomopathogenic fungi used for the biocontrol of insects, but its virulence is affected by insect immunity. We identified a novel FK506 binding protein gene that was differentially expressed between control and Metarhizium-treated Locusta migratoria manilensis. We hypothesized that this protein played an important role in Metarhizium infection of L. migratoria and could provide new insights for developing highly efficient entomopathogenic fungi. We, therefore, cloned the specific gene and obtained its purified protein. The gene was then named FKBP52, and its dsRNA (dsFKBP52) was synthesized and used for gene interference. Bioassay results showed that the mortality of L. migratoria treated with dsFKBP52 + Metarhizium was significantly lower than that of other treatments. Furthermore, immune-related genes (MyD88, Dorsal, Cactus, and Defensin) in L. migratoria treated with dsFKBP52 + Metarhizium showed significant upregulation compared to that treated with Metarhizium only. However, the activities of peroxidase (POD), superoxide dismutase (SOD), and calcineurin (CaN) showed fluctuations. These results suggest that the FKBP52 gene may play a crucial role in the innate immunity of L. migratoria. The effect of its silencing indicated that this immunity-related protein might be a potential target for insect biocontrol.
Predictors of adherence to a brief sleep extension protocol in emerging adults
Authors: Wright Isabella D , Jensen Chad D , Duraccio Kara M 
Published: April 2024

Abstract

Objectives
This study examined how mental health symptoms (i.e., depression, anxiety, stress) and baseline sleep characteristics (i.e., sleep quality and levels of daytime sleepiness) predicted adherence to and initial success of a brief sleep extension research protocol in emerging adults.

Methods
184 emerging adults (ages 18–25; M = 20.96, SD = 2.04) were asked to extend their nightly sleep opportunity to 8 hr for 1 week and to anchor bedtime and waketime. Sleep outcomes (adherence and initial protocol success) were tracked using actigraphy. Baseline sleep quality, daytime sleepiness, depression, anxiety, and stress were assessed using self-report questionnaires.

Results
Poorer baseline sleep quality predicted better adherence to the protocol (p = .002). Other baseline sleep characteristics and mental health were not predictive of adherence (ps&gt;.50). Lower levels of baseline daytime sleepiness approached significance in predicting greater initial protocol success following the protocol (p = .05). Baseline sleep quality and mental health did not predict initial protocol success (ps &gt; 0.34).

Conclusions
Mental health symptoms did not significantly predict adherence to or the success of a sleep extension protocol. Surprisingly, individuals with poor baseline sleep quality were more likely to adhere to the extension protocol, perhaps suggesting heightened motivation for change or increased risk for sleep problems. This research provides valuable insight into factors that predict adherence to sleep extension protocols in emerging adults.
Scutellarein: a review of chemistry and pharmacology
Authors: Thoa Nguyen Thi , Son Ninh The 
Published: April 2024

Abstract

Objectives
To get a better understanding of the scientific values of flavone scutellarein (SCT), and to encourage its applications in human health, the current review systematically summarizes the natural observation, biosynthesis, synthesis, pharmacology, pharmacokinetics, and recent synthetic advances

Key findings
Scientific sources to search for references included Google Scholar, Scopus, Web of Science, PubMed, Sci-Finder, and journal websites. The references have been collected from the 1970s to the present. “Scutellarein” is the most meaningful keyword to search for publications, in which it was used alone or in combination with other keywords.

Summarys
SCT as a hydrophobic flavonoid can be found in various medicinal plants of the families Lamiaceae, Compositae, and Verbenaceae. Flavone SCT has drawn much interest due to its wide pharmacological effects, such as anticancer, anti-inflammation, antioxidant, antiobesity, and vasorelaxant. The SCT treatments also possessed a lot of positive results in the neuron, liver, heart, lung, kidney, bone, and skin protective experiments, and human sperm function enhancement. Its underlying mechanism of action may relate to the apoptotic program and cytokine inhibition by regulating a panel of the signaling pathway, e.g., NF-κB (nuclear factor kappa B)/MAPK (mitogen-activated protein kinase), IκBa (nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitors alpha)/NF-κB, TRAF2 (tumor necrosis factor receptor-associated factor 2)/NF-κB, and PTEN (phosphatase and tension homologue deleted on chromosome 10)/Akt (protein kinase B)/NF-κB. In addition, the metabolic actions and synthetic derivative promotions of SCT were mostly based on the substitution of hydroxyl groups. Collectively, the studies that aim to highlight the role of scutellarein in preclinical and clinical treatments are urgently needed. More and more experiments to improve its bioavailability are expected.
Up to the chest in bowels: case of strangulated right diaphragmatic hernia with paraesophageal hernia in a non-trauma patient
Authors: Maginot Elizabeth R , Lizalek Jason , Matos Mike 
Published: April 2024

Abstract
A Bochdalek hernia is a rare congenital diaphragmatic hernia often diagnosed in infancy and classically occurring on the left side. We report a case of a 78-year-old female who presented with a right-sided posterolateral diaphragmatic hernia containing multiple loops of bowel with evidence of ischemia as well as a type 4 paraesophageal hernia. The stomach was rotated on the organoaxial plane, and the duodenum was within the mediastinum. The patient was taken emergently for an exploratory laparotomy. A posterolateral hernia defect containing 50 cm of strangulated small bowel was identified and resected, a primary stapled enteroenterostomy was performed and the hernia defect was repaired primarily. The stomach was reduced, a primary crura repair was performed, and gastropexy was performed with a gastrojejunostomy tube. The patient was transferred to the intensive care unit, and subsequently extubated, enteral feeds were initiated, and had anticipated discharge to a skilled nursing facility. This case highlights an uncommon atraumatic presentation of an adult with a congenital diaphragmatic hernia. Its rarity is further denoted due to its right-sided laterality and strangulated small bowel as the usual herniated abdominal organs are the liver or colon.
Consciousness isn’t “hard”—it’s human psychology that makes it so!
Authors: Berent Iris 
Published: April 2024

Abstract
Consciousness arguably presents a “hard problem” for scholars. An influential position asserts that the “problem” is rooted in ontology—it arises because consciousness “is” distinct from the physical. “Problem intuitions” are routinely taken as evidence for this view. In so doing, it is assumed that (i) people do not consider consciousness as physical and (ii) their intuitions faithfully reflect what exists (or else, intuitions would not constitute evidence). New experimental results challenge both claims. First, in some scenarios, people demonstrably view consciousness as a physical affair that registers in the body (brain). Second, “problem intuitions” are linked to psychological biases, so they cannot be trusted to reflect what consciousness is. I conclude that the roots of the “hard problem” are partly psychological. Accordingly, its resolution requires careful characterization of the psychological mechanisms that engender “problem intuitions.”
Single-nucleus transcriptomics uncovers a geroprotective role of YAP in primate gingival aging
Authors: Hu Qinchao , Zhang Bin , Jing Yaobin , Ma Shuai , Hu Lei , Li Jingyi , Zheng Yandong , Xin Zijuan , Peng Jianmin , Wang Si , Cheng Bin , Qu Jing , Zhang Weiqi , Liu Guang-Hui , Wang Songlin 
Published: April 2024

Abstract
Aging has a profound impact on the gingiva and significantly increases its susceptibility to periodontitis, a worldwide prevalent inflammatory disease. However, a systematic characterization and comprehensive understanding of the regulatory mechanism underlying gingival aging is still lacking. Here, we systematically dissected the phenotypic characteristics of gingiva during aging in primates and constructed the first single-nucleus transcriptomic landscape of gingival aging, by which a panel of cell type-specific signatures were elucidated. Epithelial cells were identified as the most affected cell types by aging in the gingiva. Further analyses pinpointed the crucial role of YAP in epithelial self-renew and homeostasis, which declined during aging in epithelial cells, especially in basal cells. The decline of YAP activity during aging was confirmed in the human gingival tissues, and downregulation of YAP in human primary gingival keratinocytes recapitulated the major phenotypic defects observed in the aged primate gingiva while overexpression of YAP showed rejuvenation effects. Our work provides an in-depth understanding of gingival aging and serves as a rich resource for developing novel strategies to combat aging-associated gingival diseases, with the ultimate goal of advancing periodontal health and promoting healthy aging.
A New Perspective on Thermal Transition in QCD
Authors: Hanada Masanori , Ohata Hiroki , Shimada Hidehiko , Watanabe Hiromasa 
Published: April 2024

Abstract
Motivated by the picture of partial deconfinement developed in recent years for large-N gauge theories, we propose a new way of analyzing and understanding thermal phase tsuppransition in QCD. We find nontrivial support for our proposal by analyzing the WHOT-QCD collaboration’s lattice configurations for SU(3) QCD in 3 + 1 spacetime dimensions with up, down, and strange quarks. We find that the Polyakov line (the holonomy matrix around a thermal time circle) is governed by the Haar-random distribution at low temperatures. The deviation from the Haar-random distribution at higher temperatures can be measured via the character expansion, or equivalently, via the expectation values of the Polyakov loop defined by the various nontrivial representations of SU(3). We find that the Polyakov loop corresponding to the fundamental representation and loops in the higher representation condense at different temperatures. This suggests that there are three phases, one intermediate phase existing in between the completely-confined and the completely-deconfined phases. Our identification of the intermediate phase is supported also by the condensation of instantons: by studying the instanton numbers of the WHOT-QCD configurations, we find that the instanton condensation occurs for temperature regimes corresponding to what we identify as the completely-confined and intermediate phases, whereas the instantons do not condense in the completely-deconfined phase. Our characterization of confinement based on the Haar-randomness explains why the Polyakov loop is a good observable to distinguish the confinement and the deconfinement phases in QCD despite the absence of the $\mathbb {Z}_3$ center symmetry.
Benefits and Challenges of Implementing an Adaptation of Family Integrated Care in a Ugandan Setting
Authors: Feeley Nancy , Kabajaasi Olive , Kenya-Mugisha Nathan , Tagoola Abner , O’Brien Karel , Duby Jessica 
Published: April 2024

Background:
Family Integrated Care (FICare) integrates parents as partners in neonatal intensive care unit care. Our team adapted and implemented this approach in a Ugandan unit for hospitalized neonates.

Purpose:
This qualitative descriptive study examined the perceptions of mothers and healthcare professionals (HCPs) of the benefits and challenges of this new approach to care.

Methods:
Fifty-one mothers of hospitalized neonates born weighing greater than 2000 g participated in the program. They were taught to assess neonate danger signs, feeding, and weight. After discharge, a subsample (n = 15) participated in focus groups to explore benefits and challenges of their participation in care. Interviews with 8 HCPs were also conducted for the same purpose. Transcripts from focus groups and interviews were analyzed using inductive content analysis to describe the benefits and challenges from the perspectives of mothers and HCPs.

Results:
For mothers a benefit was decreased stress. Both mothers and HCPs reported that the knowledge and skills mothers acquired were a benefit as was their ability to apply these to the care of their neonate. Improved relations between mothers and HCPs were described, characterized by greater exchange of information and HCPs’ attentiveness to mothers’ assessments. Mothers felt ready for discharge and used their knowledge at home. HCPs noted a decrease in their workload. Challenges included the need for mothers to overcome fears about performing the tasks, their own well-being and literacy skills, and access to equipment.

Implications for Practice:
Mothers’ participation in their neonates’ care can have benefits for them and their neonate.
Proximity Between Screw and Endplate of Upper Instrumented Vertebra Using a Cortical Bone Trajectory Screw can Increase Radiographic Adjacent Segment Degeneration Risks in Patients With Lumbar Spinal Stenosis
Authors: Kwon Ji-Won , Park Yung , Suk Kyung-Soo , Lee Byung Ho , Park Si Young , Park Sub-Ri , Kim Namhoo , Lee Hyunjun , Jung Wooseok , Ha Joong-Won , Moon Seong-Hwan , Kim Hak-Sun 
Published: April 2024

Study Design.
Retrospective observational study.

Objective.
To determine the proximity between the screw and endplate of the upper instrumented vertebra (UIV) using a cortical bone trajectory (CBT) screw as a predictive factor for radiographic adjacent segment degeneration (ASD) in patients surgically treated with transforaminal lumbar interbody fusion (TLIF) with CBT screws (CBT-TLIF) with lumbar spinal stenosis.

Summary of Background Data.
The risk factors for radiographic ASD after CBT-TLIF remain unknown.

Methods.
Among patients surgically treated with CBT-TLIF at a single institute, 239 consecutive patients (80 males and 159 females) were enrolled. ASD was defined by the presence of one or more of the following three radiologic criteria on the adjacent segment: >3 mm anteroposterior translation, >10° segmental kyphosis, or >50% loss of disc height comparing immediate postoperative and one-year follow-up radiographs. Clinical and radiological features associated with the development of ASD were retrospectively measured. Univariate and multivariate analyses were performed to identify risk factors associated with radiographic ASD.

Results.
Radiographic ASD was observed in 71 (29.7%) cases at one-year postoperative follow-up. The preoperative Pfirrmann grade of the adjacent segment (>grade 2), multi-level fusion (>2 levels), and proximity between the tip of CBT screws and endplate on the UIV were significantly associated with radiographic ASD (OR = 3.98, 95% CI [1.06–15.05], P=0.042 versus OR = 3.03, 95% CI [1.00–9.14], P=0.049 versus OR = 0.53, 95% CI [0.40–0.72], P<0.001). The cut-off value of the distance between the tip of the screw and endplate on UIV for radiographic ASD was ~2.5 mm (right-sided CBT screw; cut-off value 2.48 mm/ left-sided CBT screw; cut-off value 2.465 mm).

Conclusion.
Radiographic adjacent segment degeneration progression can occur when the cortical trajectory bone screw is close to the endplate of the upper instrumented vertebrae in patients with lumbar spinal stenosis undergoing fusion surgery.
Anaerobic Lactate Production Is Associated With Decreased Microcirculatory Blood Flow and Decreased Mitochondrial Respiration Following Cardiovascular Surgery With Cardiopulmonary Bypass*
Authors: Greenwood John C. , Talebi Fatima M. , Jang David H. , Spelde Audrey E. , Gordon Emily K. , Horak Jiri , Acker Michael A. , Kilbaugh Todd J. , Shofer Frances S. , Augoustides John G. T. , Brenner Jacob S. , Muzykantov Vladimir R. , Bakker Jan , Abella Benjamin S. 
Published: April 2024

OBJECTIVES:
Quantify the relationship between perioperative anaerobic lactate production, microcirculatory blood flow, and mitochondrial respiration in patients after cardiovascular surgery with cardiopulmonary bypass.

DESIGN:
Serial measurements of lactate-pyruvate ratio (LPR), microcirculatory blood flow, plasma tricarboxylic acid cycle cycle intermediates, and mitochondrial respiration were compared between patients with a normal peak lactate (≤ 2 mmol/L) and a high peak lactate (≥ 4 mmol/L) in the first 6 hours after surgery. Regression analysis was performed to quantify the relationship between clinically relevant hemodynamic variables, lactate, LPR, and microcirculatory blood flow.

SETTING:
This was a single-center, prospective observational study conducted in an academic cardiovascular ICU.

PATIENTS:
One hundred thirty-two patients undergoing elective cardiovascular surgery with cardiopulmonary bypass.

INTERVENTIONS:
None.

MEASUREMENTS AND MAIN RESULTS:
Patients with a high postoperative lactate were found to have a higher LPR compared with patients with a normal postoperative lactate (14.4 ± 2.5 vs. 11.7 ± 3.4; p = 0.005). Linear regression analysis found a significant, negative relationship between LPR and microcirculatory flow index (r = –0.225; β = –0.037; p = 0.001 and proportion of perfused vessels: r = –0.17; β = –0.468; p = 0.009). There was not a significant relationship between absolute plasma lactate and microcirculation variables. Last, mitochondrial complex I and complex II oxidative phosphorylation were reduced in patients with high postoperative lactate levels compared with patients with normal lactate (22.6 ± 6.2 vs. 14.5 ± 7.4 pmol O2/s/106 cells; p = 0.002).

CONCLUSIONS:
Increased anaerobic lactate production, estimated by LPR, has a negative relationship with microcirculatory blood flow after cardiovascular surgery. This relationship does not persist when measuring lactate alone. In addition, decreased mitochondrial respiration is associated with increased lactate after cardiovascular surgery. These findings suggest that high lactate levels after cardiovascular surgery, even in the setting of normal hemodynamics, are not simply a type B phenomenon as previously suggested.
Clinical efficacy of EUS-guided celiac plexus neurolysis versus EUS-guided celiac ganglion irradiation with iodine-125 seeds for pain relief in advanced pancreatic cancer: A long-term retrospective study
Authors: Zhang Ping-Ping , Su Xiao-Ju , Li Li , Wang Yu-Ling , Zhu Dong-Qing , Yang Ting , Wang Teng , Jin Zhen-Dong , Wang Kai-Xuan 
Published: April 2024

ABSTRACT

Background and Objective
To compare the efficacy of EUS–guided celiac plexus neurolysis (CPN) and celiac plexus irradiation with iodine-125 (125I) seeds with absolute ethanol for relieving pain in patients with advanced pancreatic cancer.

Methods
We retrospectively analyzed data of 81 patients with advanced pancreatic cancer who underwent EUS-CPN or EUS-125I implantation between January 2017 and December 2020. Postoperative pain was assessed using visual analog scale (VAS) scores; self-assessments of quality of life and the median survival time were compared between the 2 groups.

Results
EUS-CPN and 125I implantation were performed in 43 and 38 patients, respectively. Postoperative VAS scores were significantly lower than the preoperative levels in both groups. One week after the operation, 26 patients (60.5%) in the EUS-CPN group achieved partial pain relief, whereas no patients in the EUS-125I seed group experienced pain relief. However, after 4 weeks postoperatively, VAS scores had decreased, and the rate of partial pain relief was higher for EUS-125I seeds than for EUS-CPN. Self-assessments of quality of life were similar in both groups during the first 1 month after the procedure.

Conclusions
Both EUS-CPN and EUS-125I seeds can safely and effectively relieve pain in patients with advanced pancreatic cancer. Although EUS-125I seeds take additional time to show effects, the extent and duration of pain relief are better compared with CPN, and interestingly, the median survival time was different.
N-N-Butyl Haloperidol Iodide Mitigates Myocardial Ischemia/Reperfusion Injury Through Activation of SIRT1-Nrf2 Signaling Loop
Authors: Lu Binger , Feng Zikai , Wang Yali , Liao Jilin , Wang Bin , Gao Fenfei , Zheng Fuchun , Shi Ganggang , Zhang Yanmei 
Published: April 2024

Abstract:

N-n-butyl haloperidol iodide (F2), a derivative of haloperidol developed by our group, exhibits potent antioxidative properties and confers protection against cardiac ischemia/reperfusion (I/R) injury. The protective mechanisms by which F2 ameliorates I/R injury remain obscure. The activation of nuclear factor erythroid 2-related factor 2 (Nrf2), a key transcription factor transactivating many antioxidative genes, also attenuates I/R-induced myocardial damage. The present study investigated whether the cardioprotective effect of F2 depends on Nrf2 using a mouse heart I/R model. F2 (0.1, 0.2 or 0.4 mg/kg) or vehicle was intravenously injected to mice 5 minutes before reperfusion. Systemic administration of 0.4 mg/kg F2 led to a significant reduction in I/R injury, which was accompanied by enhanced activation of Nrf2 signaling. The cardioprotection conferred by F2 was largely abrogated in Nrf2-deficient mice. Importantly, we found F2-induced activation of Nrf2 is silent information regulator of transcription 1 (SIRT1)-dependent, as pharmacologically inhibiting SIRT1 by the specific inhibitor EX527 blocked Nrf2 activation. Moreover, F2-upregulated expression of SIRT1 was also Nrf2-dependent, as Nrf2 deficiency inhibited SIRT1 upregulation. These results indicate that SIRT1-Nrf2 signaling loop activation is indispensable for the protective effect of F2 against myocardial I/R injury and may provide new insights for the treatment of ischemic heart disease.