bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sleep Exacerbation of Persistent Sexual Arousal Syndrome in a Postmenopausal Woman
Authors: Wylie Kevan , Levin Roy , Hallam-Jones Ruth , Goddard Amanda 
Published: October 2005

ABSTRACT

Aim
To investigate possible causes and treatment of persistent sexual arousal syndrome, which was exacerbated by sleep onset, in a postmenopausal subject.

Methods
A clinical examination and interviews with the patient to obtain her case history and follow-up of the effects of drug treatments. Pretreatment laboratory investigations monitored vaginal blood flow by photoplethysmography and heated electrode. Routine blood chemistry and endocrine assessments were undertaken. Magnetic resonance imaging (MRI) scans of brain, pelvis, and spinal cord and genito-sensory neural analysis of clitoral and vaginal areas were performed. A selective internal iliac artery arteriogram was utilized to check the normality of the pelvic blood supply.

Results
Genitalia appeared normal and uncongested. No structural abnormalities were observed in the MRI scans. Hormonal levels and blood chemistry were commensurate with the subject's postmenopausal status. Basal vaginal blood flow (heat electrode) was within the range of normal premenopausal women and showed (photoplethysmography) normal vasomotion. On becoming drowsy and falling lightly asleep in the laboratory the vaginal pulse amplitude (VPA) increased by 95% of the basal value and the low-amplitude VPAs were replaced by high-amplitude VPAs—all evidence of increased vaginal blood flow and congestion and confirming the subject's complaint of persistent sexual arousal during sleep. A simple cognitive task of repeatedly subtracting 7 from 500 out aloud did not hasten the reversion to the basal level. There was no evidence of malfunction of the brain, spinal cord, or pelvic area by MRI but genito-sensory analysis of the clitoral and vaginal area showed evidence of reduced sensory function.

Conclusions
Of the treatments tried only risperidone has been effective allowing the subject to sleep throughout the night without disturbance and according to the subject has significantly reduced the aggravation of the arousal during the day.
Impact of Physician Gender on Sexual History Taking in a Multispecialty Practice
Authors: Burd Irina D. , Nevadunsky Nicole , Bachmann Gloria 
Published: October 2005

ABSTRACT

Introduction
Identification of sexual dysfunction may help physicians diagnose problems such as diabetes, pituitary tumors, atherosclerosis, and depression. Sexual concerns are common among patients; however, there is evidence to suggest that these concerns are not appropriately investigated by clinicians.

Aim
To examine the impact of physician gender on sexual history taking.

Methods
One hundred and thirty-one study questionnaires were sent to OB/Gyns, family practitioners, internists, pediatricians, and surgeons. Physicians were asked to rank their discomfort during interviews with patients of different ages, races, marital status, sexual preference, religious beliefs, and academic achievement, and they were asked to rank their perception of patient discomfort.

Main Outcome Measures
A cross-sectional descriptive analysis was generated, Fisher's exact test was performed utilizing SPSS software, and confidence intervals were developed utilizing SAS software.

Results
Of the 78 questionnaires (59%) returned, 69 (88%) reported taking sexual histories. Characteristics identified by physicians as causing discomfort included patient's age younger than 18 and greater than 65, patient's academic achievement below college level, and patient's divorced or single marital status. Moreover, there was a statistically significant difference (P &lt; 0.05) between male and female physicians reporting their discomfort when interviewing males (19% and 50%, respectively) and females (35% and 12%, respectively).

Conclusion
Although a high percentage of practitioners report taking a sexual history, physicians reported and perceived greatest discomfort when interviewing opposite gender patients as well as patients of very young and old ages. It is clear that not only is there a need for physician education on the topic of sexual history taking, but also consideration of the impact of physician and patient gender.
Polymorphisms at +49A/G and CT60 sites in the 3′ UTR of the CTLA‐4 gene and APECED‐related AIRE gene mutations analysis in sporadic idiopathic hypoparathyroidism
Authors: Goswami R. , Gupta N. , Ray D. , Rani R. , Tomar N. , Sarin R. , Vupputuri M. R. 
Published: October 2005

SummaryAutoimmune diseases such as Graves’ disease and type 1 diabetes have been linked with +49A/G and CT60 single nucleotide polymorphisms (SNPs) in the 3′ UTR of the cytotoxic T‐lymphocyte antigen‐4 (CTLA‐4) gene. Both these SNPs are functionally relevant and linked with T‐lymphocyte activation. Hypoparathyroidism is seen in 70% of patients with autoimmune polyendocrinopathy candidiasis ectodermal dystrophy syndrome (APECED). Although calcium sensing receptor autoantibodies (CaSRAb) and generalized activation of T lymphocytes are reported among patients with sporadic idiopathic hypoparathyroidism (SIH), CTLA‐4 gene SNPs and APECED‐related autoimmune regulator (AIRE) gene mutations have not been assessed in them. We studied lead CTLA‐4 gene SNPs and APECED‐related AIRE gene mutations in 73 patients with SIH and 114 healthy subjects. The CTLA‐4 gene SNPs +49A/G in exon 1, CT60A/G in 3′ UTR and −318C/T in the promoter region were genotyped by polymerase chain reaction‐restriction fragment‐length polymorphism (PCR‐RFLP) using BstEII, NcoI and MseI endonucleases, respectively. The APECED‐related AIRE gene mutations, which is R257X (Finn‐major) in exon 6, 4‐bp insertion and 13‐bp deletion in exon 8, and Iranian Jews population ‘Y85C’ mutation in exon 2, were studied by PCR‐RFLP (Taq‐I), PCR and nucleotide sequencing, respectively. CaSRAb were studied by immunoblotting. The frequencies of CTLA‐4 A/A49, A/G49 and G/G49 genotypes in the patients (47.9%, 38.4% and 13.7%) and controls (45.6%, 39.5% and 14.9%, respectively) and the frequencies of CT60 A/A, A/G, and G/G genotypes in the patient (42.4%, 37.0% and 20.6%) and the control (38.6%, 40.4% and 21.0%, respectively) groups were not significantly different. The frequencies of various haplotypes including genetic loci +49A/G and CT60 and frequencies of G alleles at these positions were comparable between patient and the control groups and its presence did not correlate with clinical and biochemical indices of the disease. None of the patients had APECED‐related AIRE gene mutations. Lack of significant difference in the pattern of CTLA‐4 A/G49 and/or CT60A/G genotypes and absence of common APECED syndrome‐related AIRE gene mutations among patients and controls suggest that these sites do not play a role in the development of the SIH.
HLA and eye disease: a synopsis
Authors: Goverdhan S. V. , Lotery A. J. , Howell W. M. 
Published: October 2005

SummaryHuman leukocyte antigen (HLA) gene products have been implicated in the pathogenesis of an increasing number of eye diseases, mainly inflammatory in nature. This perspective reviews the current hypotheses for why HLA polymorphisms are associated with specific eye diseases. Statistical problems in studies involving HLA associations are discussed, and possible solutions outlined. The relevance of HLA testing in routine ophthalmic practice, its practical and cost implications is also assessed.
The Four Sources of Law in Zoroastrian and Islamic Jurisprudence
Authors: János Jany 
Published: October 2005

AbstractIt is "only our lack of familiarity with Sasanian law," von Grunebaum opined (1970: 37), "that prevents us from uncovering its traces in the fiqh". And Joseph Schacht argued that Sasanian law did have an influence on Islamic law. But neither Schacht nor any other modern scholar has provided persuasive evidence for such influence. In this article I argue that the influence of Sasanian legal theory on Islamic legal theory in the formative period was minimal, at best. It is true that, like Islamic law, Sasanian law was based on four sources: (1) The Awesta or holy book of the Zoroastrians; (2) oral law; (3) the consensus of the sages; and (4) the judicial practice of the courts (kardag). However, the possibility of Iranian influence on early Islamic jurisprudence is limited by historical, cultural, geographical and chronological factors, and the evidence of the sources suggests that Sasanian legal thinking was distinctive from that of the Sunni usulis.
Daytime Cycle of Low-Level Clouds and the Tropical Convective Boundary Layer in Southwestern Amazonia
Authors: Strong C. , Fuentes J. D. , Garstang M. , Betts A. K. 
Published: October 2005

Abstract
During the wet season in the southwestern Amazon region, daytime water transport out of the atmospheric mixed layer into the deeper atmosphere is shown to depend upon cloud amounts and types and synoptic-scale velocity fields. Interactions among clouds, convective conditions, and subcloud-layer properties were estimated for two dominant flow regimes observed during the 1999 Tropical Rainfall Measuring Mission component of the Brazilian Large-Scale Biosphere–Atmosphere (TRMM-LBA) field campaign. During daytime the cloud and subcloud layers were coupled by radiative, convective, and precipitation processes. The properties of cloud and subcloud layers varied according to the different convective influences of easterly versus westerly lower-tropospheric flows. The most pronounced flow-regime effects on composite cloud cycles occurred under persistent lower-tropospheric flows, which produced strong convective cloud growth with a near absence of low-level stratiform clouds, minimal cumulative attenuation of incoming solar irradiance (∼25%), rapid daytime mixed-layer growth (&gt;100 m h−1), and boundary layer drying (0.22 g kg−1 h−1), high convective velocities (&gt;1.5 m s−1), high surface buoyancy flux (&gt;200 W m−2), and high latent heat flux (600 W m−2) into cloud layer. In contrast, persistent westerly flows were less convective, showing a strong morning presence of low-level stratiform genera (&gt;0.9 cloud amount), greater cumulative attenuation of incoming solar irradiance (∼47%), slower mixed-layer growth (&lt;50 m h−1) with a slight tendency for mixed-layer moistening, and a delayed peak in the low-level cumuliform cloud cycle (2000 versus 1700 UTC). The results reported in this article indicate that numerical models need to account for cloud amounts and types when estimating water vapor transport to the cloud layer.
Incorporation of CO2 Exchange Processes into a Multilayer Atmosphere–Soil–Vegetation Model
Authors: Nagai Haruyasu 
Published: October 2005

Abstract
Carbon dioxide (CO2) exchange processes were incorporated into a multilayer atmosphere–soil–vegetation model known as SOLVEG, and its performance was examined using measurements obtained from a grassland site. It was also applied for the CO2 budget calculation in the surface ecosystem. The characteristic feature of this model is that it is multilayered for the atmosphere, soil, and vegetation and includes sophisticated processes involving transmission of the solar and longwave radiation fluxes in the canopy. The model framework for the heat and water exchanges between the atmosphere and ground surface was validated by comparisons of ground surface heat fluxes between the calculated and observed values in the previous papers. In this study, a new model framework that includes the exchange process of CO2 along with those of heat, water, and momentum, which interact with each other, has been developed. The performance of the model was examined by comparing the calculated and observed values for surface fluxes of heat, water, and CO2. Because no measurements are available for the direct evaluation of the CO2 calculation in the soil, the calculation has been examined by drawing comparisons between the CO2 fluxes above the ground in the period lacking active vegetation. Vegetation parameters were tuned using measurements of 2 months, and the model satisfactorily simulated measured fluxes for the 8-month-long test period. Moreover, the CO2 budget in the surface ecosystem was examined using the model simulation. The result indicates the necessity of the incorporated CO2 process for the CO2 budget in the surface ecosystem.
Climatologically Aided Mapping of Daily Precipitation and Temperature
Authors: Hunter Richard D. , Meentemeyer Ross K. 
Published: October 2005

AbstractAccurately mapped meteorological data are an essential component for hydrologic and ecological research conducted at broad scales. A simple yet effective method for mapping daily weather conditions across heterogeneous landscapes is described and assessed. Daily weather data recorded at point locations are integrated with long-term-average climate maps to reconstruct spatially explicit estimates of daily precipitation and temperature extrema. The method uses ordinary kriging to interpolate base station data spatially into fields of approximately 2-km grain size. The fields are subsequently adjusted by 30-yr-average climate maps [Parameter-Elevation Regression on Independent Slopes Model (PRISM)], which incorporate adiabatic lapse rates, orographic effects, coastal proximity, and other environmental factors. The accuracy assessment evaluated an interpolation-only approach and the new method by comparing predicted and observed values from an independent validation dataset. The results of the accuracy assessment are compared for a 24-yr period for California. For all three weather variables, mean absolute errors (MAE) of the climate-imprint method were considerably smaller than those of the interpolation-only approach. MAE for predicted daily precipitation was ±2.5 mm, with a bias of +0.01. MAE for predicted daily minimum and maximum temperatures were ±1.7° and ±2.0°C, respectively, with corresponding biases of −0.41° and −0.38°C. MAE differed seasonally for all three weather variables, but the method was stable despite variation in the number of base stations available for each day.
Arctic Cloud Microphysics Retrievals from Surface-Based Remote Sensors at SHEBA
Authors: Shupe Matthew D. , Uttal Taneil , Matrosov Sergey Y. 
Published: October 2005

Abstract
An operational suite of ground-based, remote sensing retrievals for producing cloud microphysical properties is described, assessed, and applied to 1 yr of observations in the Arctic. All measurements were made in support of the Surface Heat Budget of the Arctic (SHEBA) program and First International Satellite Cloud Climatology Project Regional Experiment (FIRE) Arctic Clouds Experiment (ACE) in 1997–98. Retrieval techniques and cloud-type classifications are based on measurements from a vertically pointing 35-GHz Doppler radar, microwave and infrared radiometers, and radiosondes. The retrieval methods are assessed using aircraft in situ measurements from a limited set of case studies and by intercomparison of multiple retrievals for the same parameters. In all-liquid clouds, retrieved droplet effective radii Re have an uncertainty of up to 32% and liquid water contents (LWC) have an uncertainty of 49%–72%. In all-ice clouds, ice particle mean sizes Dmean can be retrieved with an uncertainty of 26%–46% while retrieved ice water contents (IWC) have an uncertainty of 62%–100%. In general, radar-only, regionally tuned empirical power-law retrievals were best suited among the tested retrieval algorithms for operational cloud monitoring at SHEBA because of their wide applicability, ease of use, and reasonable statistical accuracy. More complex multisensor techniques provided a moderate improvement in accuracy for specific case studies and were useful for deriving location-specific coefficients for the empirical retrievals but were not as frequently applicable as the single sensor methods because of various limitations. During the yearlong SHEBA program, all-liquid clouds were identified 19% of the time and were characterized by an annual average droplet Re of 6.5 μm, LWC of 0.10 g m−3, and liquid water path of 45 g m−2. All-ice clouds were identified 38% of the time with an annual average particle Dmean of 73 μm, IWC of 0.014 g m−3, and ice water path of 30 g m−2.
Microphysical Processes and Synergistic Interaction between Frontal and Orographic Forcing of Precipitation during the 13 December 2001 IMPROVE-2 Event over the Oregon Cascades
Authors: Woods Christopher P. , Stoelinga Mark T. , Locatelli John D. , Hobbs Peter V. 
Published: October 2005

Abstract
On 13–14 December 2001 a vigorous cyclonic storm passed over the Pacific Northwest, producing heavy orographic precipitation over the Cascade Mountains. This storm was one of several studied during the second field phase of the Improvement of Microphysical Parameterization through Observational Verification Experiment (IMPROVE). A wide variety of in situ and remotely sensed measurements were obtained as this storm passed over the Oregon Cascades. These measurements provided a comprehensive dataset of meteorological state parameters (temperature, pressure, humidity, winds, and vertical air velocity), polarization Doppler radar measurements, and cloud microphysical parameters (cloud liquid water, particle concentrations, size spectra, and imagery).
The 13–14 December case was characterized by the passage of a tipped-forward lower-tropospheric front that extended upward to a preceding vigorous upper cold-frontal rainband, which produced clouds up to ∼8–9 km. An important difference between this storm and those studied previously over the Washington Cascades was that the prefrontal low-level airflow over the Oregon Cascades was characterized by strong westerly (as opposed to weak easterly) cross-barrier flow. Consequently, as the upper cold-frontal band passed over the Oregon Cascades there was both strong ice particle production aloft and significant production of liquid water at lower levels in the orographic lifting zone. Airborne in situ measurements, ground-based microwave radiometer measurements, and observations of snow crystals showed the simultaneous presence of high ice crystal concentrations and relatively large values of cloud liquid water aloft, and heavily rimed particles reaching the ground. Analyses indicate that a synergistic interaction occurred between the frontal and orographic precipitation.
The 13–14 December 2001 IMPROVE-2 Event. Part II: Comparisons of MM5 Model Simulations of Clouds and Precipitation with Observations
Authors: Garvert Matthew F. , Woods Christopher P. , Colle Brian A. , Mass Clifford F. , Hobbs Peter V. , Stoelinga Mark T. , Wolfe Justin B. 
Published: October 2005

Abstract
This paper compares airborne in situ observations of cloud microphysical parameters with the fifth-generation Pennsylvania State University–National Center for Atmospheric Research (PSU–NCAR) Mesoscale Model (MM5) simulations, using the Reisner-2 bulk microphysical parameterization, for a heavy precipitation event over the Oregon Cascades on 13–14 December 2001.
The MM5 correctly replicated the extent of the snow field and the growth of snow particles by vapor deposition measured along aircraft flight tracks between altitudes of 4.9 and 6 km, but overpredicted the mass concentrations of snow. The model produced a broader number distribution of snow particles than observed, overpredicting the number of moderate-to-large-sized snow particles and underpredicting the number of small particles observed along the aircraft flight track. Over the mountain crest, the model overpredicted depositional growth of snow and mass concentrations of snow, but underpredicted the amount of cloud liquid water and conversion of snow to graupel. The misclassification of graupel as snow and excessive amounts of snow resulted in the model overpredicting precipitation on the lee slopes and in localized areas along the foothills of the Cascades. The model overpredicted cloud liquid water over the lower windward slopes and foothills, where accretion of cloud liquid water by rain was the primary precipitation-producing mechanism.
The 13–14 December 2001 IMPROVE-2 Event. Part III: Simulated Microphysical Budgets and Sensitivity Studies
Authors: Colle Brian A. , Garvert Matthew F. , Wolfe Justin B. , Mass Clifford F. , Woods Christopher P. 
Published: October 2005

Abstract
This paper investigates the microphysical pathways and sensitivities within the Reisner-2 bulk microphysical parameterization (BMP) of the fifth-generation Pennsylvania State University–National Center for Atmospheric Research (PSU–NCAR) Mesoscale Model (MM5) for the Improvement of Microphysical Parameterization through Observational Verification Experiment (IMPROVE)-2 field experiment on 13–14 December 2001. A microphysical budget over the windward slope at 1.33-km horizontal grid spacing was calculated, in which the importance of each microphysical process was quantified relative to the water vapor loss (WVL) rate. Over the windward Cascades, the largest water vapor loss was associated with condensation (73% of WVL) and snow deposition (24%), and the windward surface precipitation resulted primarily from accretion of cloud water by rain (27% of WVL), graupel fallout and melt (19%), and snowmelt (6%). Two-thirds of the snow generated aloft spilled over into the lee in an area of model overprediction, resulting in windward precipitation efficiency of only 50%. Even with the large amount of precipitation spillover, the windward precipitation was still overpredicted in many locations.
A series of experiments were completed using different snowfall speeds, cloud water autoconversion, threshold riming values for snow to graupel autoconversion, and slope intercepts for snow. The surface precipitation was most sensitive to those parameters associated with the snow size distribution and fall speed, while decreasing the riming threshold for snow to graupel conversion had the greatest positive impact on the precipitation forecast. All simulations overpredicted cloud water over the lower windward slopes, had too little cloud water over the crest, and had too much ice at moderate-to-large sizes aloft. Riming processes were important, since without supercooled water there were bull’s-eyes of spurious snow spillover over the lee slopes.
NOTES AND CORRESPONDENCE: Polarimetric Radar Observation of Multiple Freezing Levels
Authors: Ikeda Kyoko , Brandes Edward A. , Rasmussen Roy M. 
Published: October 2005

Abstract
An unusual multiple freezing-level event observed with polarimetric radar during the second phase of the Improvement of Microphysical Parameterization through Observational Verification Experiments (IMPROVE-2) field program is described. The event occurred on 28 November 2001 when a warm front moved over the Oregon Cascade Mountains. As the front approached, an elevated melting layer formed above a preexisting melting layer near ground. Continued warming of the lower atmosphere eventually dissipated the lower melting layer.
The polarimetric measurements are used to estimate the height of the freezing levels, document their evolution, and deduce hydrometeor habits. The measurements indicate that when the two freezing levels were first observed melting was incomplete in the upper melting layer and characteristics of particles that passed through the two melting layers were similar. As warming progressed, the character of particles entering the lower melting layer changed, possibly becoming ice pellets or frozen drops. Eventually, the refreezing of particles ended and only rain occurred below the elevated melting layer.
The Doppler radial winds showed a well-defined wind maximum apparently associated with a “warm conveyor belt.” The jet intensified and descended through the elevated melting layer with time. However, the increase in wind speed did not appear connected with melting or result in precipitation enhancement.