bluuebunny/crossref_metadata_2025_split huggingface dataset:
High-Dose Fenretinide in Oral Leukoplakia
Authors: William William N. , Lee J. Jack , Lippman Scott M. , Martin Jack W. , Chakravarti Nitin , Tran Hai T. , Sabichi Anita L. , Kim Edward S. , Feng Lei , Lotan Reuben , Papadimitrakopoulou Vassiliki A. 
Published: January 2009

Abstract
We previously showed that low-dose fenretinide (200 mg/d) had limited activity in retinoid-resistant oral leukoplakia (34% response rate) possibly because serum drug levels were insufficient to induce retinoid receptor–independent apoptosis. Therefore, we designed the single-arm phase II trial reported here to investigate whether higher-dose fenretinide would improve leukoplakia response over that of our previous study. Leukoplakia patients received fenretinide (900 mg/m2 twice daily) in four 3-week cycles (1 week on drug followed by 2 weeks off). At week 12, clinical responses were determined and blood samples were collected for serum drug level assessments. A planned interim futility analysis led to early trial closure after the initial 15 (of 25 planned) patients because only 3 (20%) had a partial response (stopping rule: ≤4 responses in first 16 patients). Fenretinide was well tolerated—only one grade 3 adverse event (diarrhea) occurred. Serum fenretinide levels changed from 0 (baseline) to 0.122 ± 0.093 μmol/L (week 12). In correlative in vitro studies, high-dose fenretinide inhibited the growth of head and neck cancer cells more and oral leukoplakia cells less than did lower doses of fenretinide. This result is consistent with our clinical finding that high-dose fenretinide did not improve on the historical response rate of lower-dose fenretinide in our previous oral leukoplakia trial.
Cyclin D1 and Cancer Development in Laryngeal Premalignancy Patients
Authors: Papadimitrakopoulou Vassiliki , Izzo Julie G. , Liu Diane D. , Myers Jeffrey , Ceron Tania L. , Lewin Jan , William William N. , Atwell Anthea , Lee J. Jack , Gillenwater Ann , El-Naggar Adel , Wu Xifeng , Lippman Scott M. , Hittelman Walter N. , Hong Waun Ki 
Published: January 2009

Abstract
In a previous trial, we found that combined 13-cis-retinoic acid, IFN-α, and α-tocopherol more effectively reversed advanced premalignant lesions of the larynx than of the oral cavity and that cyclin D1 (CD1) G/A870 single nucleotide polymorphism correlated with cancer risk. We conducted the present trial primarily to confirm the clinical activity of the combination in advanced laryngeal premalignancy and to confirm and extend our findings on CD1, both genotype and protein expression, in association with cancer risk in this setting. Twenty-seven moderate-to-severe laryngeal dysplasia patients underwent induction with combined 13-cis-retinoic acid daily, α-IFN twice weekly, and α-tocopherol daily for 1 year; 14 nonprogressing patients then were randomized to maintenance fenretinide or placebo for 2 years. During induction, two patients had pathologic complete responses, six had partial responses (30% overall response rate), and five developed laryngeal cancer. There were no significant differences between maintenance fenretinide and placebo in response or cancer rates. Ten patients developed cancer overall. Twenty-four patients were evaluated for the CD1 G/A870 genotype, and 23 for pretreatment and posttreatment CD1 protein expression. Consistent with our earlier report, shorter cancer-free survival was associated with the CD1 AA/AG genotype (P = 0.05). Extending our earlier work, high CD1 expression was associated with worse cancer-free survival overall (P = 0.04) and within each CD1 genotype group. These findings support CD1 genotype and protein expression as important risk markers for laryngeal cancer and suggest future trials targeting upstream regulators of CD1 transcription.
Synthesis of Melatonin Receptor Agonist Ramelteon via Rh-catalyzed Asymmetric Hydrogenation of an Allylamine
Authors: Yamashita Masayuki , Yamano Toru 
Published: January 2009

Abstract
In the course of developing a practical synthetic method for the selective melatonin MT1/MT2 receptor agonist Ramelteon, a rhodium Josiphos complex was found to be an excellent catalyst for asymmetric hydrogenation of the key precursor, allylamine 1.
Nanoparticles of Hybrid Liposomes for the Inhibition of Breast Tumor Growth along with Apoptosis
Authors: Shimoda Shinya , Ichihara Hideaki , Matsumoto Yoko , Ueoka Ryuichi 
Published: January 2009

Abstract
Hybrid liposomes (HLs) composed of l-α-dimyristoylphosphatidylcholine and polyoxyethylene (25) dodecyl ether having 80 nm in diameter were produced. It is noteworthy that the therapeutic effects of HLs along with apoptosis without side effect were obtained using xenograft mice models of human breast cancer in vivo for the first time.
A Facile Procedure for Acetalization of Aldehydes and Ketones Catalyzed by Cerium(III) Trifluoromethanesulfonate
Authors: Ono Fumiaki , Inatomi Yoshiko , Tada Yuusuke , Mori Masaki , Sato Tsuneo 
Published: January 2009

Abstract
Aldehydes and ketones are readily protected in the presence of trialkyl orthoformate and a catalytic amount of cerium(III) trifluoromethanesulfonate under mild conditions to give the corresponding acetals in good to excellent yields. Due to the mild reaction conditions, this method is compatible with acid-sensitive substrates.
Desmids of some selected areas of Bangladesh. 3. <i>Docidium</i>, <i>Pleurotaenium</i>, <i>Triplastrum</i> and <i>Triploceras</i>
Authors: Islam AKM Nurul , Akter Nasima 
Published: January 2009

23 taxa belonging to Pleurotaenium, 2 under Triploceras and 1 each under Docidium and Triplastrum have been recorded in this paper from some selected areas of Bangladesh. Of these, 11 are new records for the country. Keywords: Desmids, Docidium, Pleurotaenium, Triplastrum, Triploceras, Bangladesh DOI: 10.3329/bjpt.v12i1.608 Bangladesh J. Plant Taxon. 12(1): 11-23, 2005 (June)
Hydrobiological studies within the tea gardens at Srimangal, Bangladesh. III. Chlorophyceae (excluding Desmids)
Authors: Islam AKM Nurul , Irfanullah Haseeb Md 
Published: January 2009

A total of 83 algal taxa belonging to 40 genera of Chlorophyceae (excluding desmids) have been recorded from some acidic water bodies within the tea gardens at Srimangal, Maulvi Bazar. Of these 14 are new records for Bangladesh. Key words Acidic habitats, phytoplankton, periphyton, Chlorophyceae, new records, Bangladesh DOI: 10.3329/bjpt.v12i2.600 Bangladesh J. Plant Taxon. 12(2): 19-37, 2005 (December)
Hydrobiological studies within the tea gardens at Srimangal, Bangladesh. VI. Desmids (<i>Xanthidium</i>, <i>Arthrodesmus</i>, <i>Staurodesmus</i> and <i>Staurastrum</i>)
Authors: Islam AKM Nurul , Irfanullah Haseeb Md 
Published: January 2009

In this last instalment of the series, 78 desmid taxa belonging to four genera, namely Xanthidium (8 taxa), Arthrodesmus (3 taxa), Staurodesmus (11 taxa) and Staurastrum (56 taxa) have been recorded from different aquatic habitats located within the tea gardens at Srimangal, Maulvi Bazar. Of these, nine are described as new records for Bangladesh. An overall assessment of the algal flora of the study area reveals desmids as the single largest group consisting of 230 taxa out of 421 recorded algal taxa. The paper comments on the conservation potentials of the studied aquatic habitats as monitoring tools of land use pattern like tea-gardening. Key words: Acidic habitats, Species diversity, Conservation, Phytoplankton, New records DOI: 10.3329/bjpt.v13i2.583 Bangladesh J. Plant Taxon. 13(2): 111-129, 2006 (December)
Scrophulariaceous taxa in Bangladesh
Authors: Rahman Mohammad Oliur 
Published: January 2009

This paper presents a total of 59 Scrophulariaceous species distributed in 23 genera from Bangladesh. An updated nomenclature, brief diagnostic characters, flowering and fruiting period and distribution within and outside Bangladesh have been furnished under each species. Chromosome number has also been cited whenever possible. Key words: Schrophulariaceae, Bangladesh DOI: 10.3329/bjpt.v13i2.585 Bangladesh J. Plant Taxon. 13(2): 139-154, 2006 (December)
A preliminary checklist of the Angiospermic flora of Ghagotia Union under Kapasia Upazila in Gazipur District, Bangladesh
Authors: Alam Mohammad Shah , Hassan Md Abul , Uddin Mohammad Zashim 
Published: January 2009

Angiospermic flora of Ghagotia Union representing Magnoliopsida (Dicots) and Liliopsida (Monocots) have been inventoried after survey during the years of 2004 and 2005. A total of 187 species have been recorded from the area. These have been assigned to 65 families and 160 genera. Magnoliopsida is represented by 50 families, 113 genera and 133 species, whereas Liliopsida is represented by 15 families, 47 genera and 54 species. Key words: Preliminary checklist, Angiospermic flora, Ghagotia Union, Gazipur, Bangladesh DOI: 10.3329/bjpt.v13i2.586 Bangladesh J. Plant Taxon. 13(2): 155-170, 2006 (December)
<i>Aleuritopteris grisea</i> (Blanford) Panigrahi : A new pteridophytic record for Bangladesh
Authors: Mirza Momtaz Mahal , Nur-E-Alam Muhammad , Ahmed Rezina 
Published: January 2009

Not available. Key words: Aleuritopteris grisea, New record, Bangladesh DOI: 10.3329/bjpt.v13i2.588 Bangladesh J. Plant Taxon. 13(2): 173-175, 2006 (December)
A new species of the genus <i>Phoebe</i> Nees (Lauraceae) from North-East India
Authors: Gangopadhyay M , Sarmah A 
Published: January 2009

Not available. Key words: Lauraceae, New species, Phoebe DOI: 10.3329/bjpt.v14i2.534 Bangladesh J. Plant Taxon. 14(2): 163-165, 2007 (December)
Systematic studies in the family Liliaceae from Bangladesh
Authors: Afroz Sumona , Hassan Md. Abul 
Published: January 2009

The family Liliaceae A.L. de Jussieu has been revised for Bangladesh and a total of 34 species with one variant under 16 genera have been recorded. Artificial dichotomous keys to the genera and species have been given. Descriptions have been provided for each taxon, and local names, flowering and fruiting periods have been added wherever available. Out of 34 species, 16 species are native/naturalized and 18 species, including 1 variant, are exotic. Four genera, ten species and one variant have been documented for the first time in Bangladesh.Keywords: Liliaceae, Systematic studies, BangladeshÂ DOI: 10.3329/bjpt.v15i2.1741Â Bangladesh J. Plant Taxon. 15(2): 115-128, 2008 (December)
Scanning electron microscopic studies on the testa surface pattern of <i>Bauhinia nervosa</i> and <i>B. wallichii</i> (Fabaceae: Caesalpinioideae)
Authors: Pathak M. K. , Bhaumik M. , Bandyopadhyay S. 
Published: January 2009

Not available.Keywords: Bauhinia, Testa surface pattern, Scanning electron microscopic studiesÂ DOI: 10.3329/bjpt.v15i2.1754Â Bangladesh J. Plant Taxon. 15(2): 159-161, 2008 (December)
Working memory interference during processing texts and pictures: Implications for the explanation of the modality effect
Authors: Rummer Ralf , Schweppe Judith , Fürstenberg Anne , Seufert Tina , Brünken Roland 
Published: December 2008

AbstractAuditory text presentation improves learning with pictures and texts. With sequential text–picture presentation, cognitive models of multimedia learning explain this modality effect in terms of greater visuo‐spatial working memory load with visual as compared to auditory texts. Visual texts are assumed to demand the same working memory subsystem as pictures, while auditory texts make use of an additional cognitive resource. We provide two alternative assumptions that relate to more basic processes: First, acoustic‐sensory information causes a retention advantage for auditory over visual texts which occurs no matter if a picture is presented or not. Second, eye movements during reading hamper visuo‐spatial rehearsal. Two experiments applying elementary procedures provide first evidence for these assumptions. Experiment 1 demonstrates that, regarding text recall, the auditory advantage is independent of visuo‐spatial working memory load. Experiment 2 reveals worse matrix recognition performance after reading text requiring eye movements than after listening or reading without eye movements. Copyright © 2008 John Wiley & Sons, Ltd.
A Straightforward Procedure for the [2+2+2] Cycloaddition of Enediynes
Authors: Geny Anaïs , Gaudrel Sophie , Slowinski Franck , Amatore Muriel , Chouraqui Gaëlle , Malacria Max , Aubert Corinne , Gandon Vincent 
Published: December 2008

AbstractEnediynes undergo intramolecular [2+2+2] cycloaddition in the presence of cobalt(II) iodide (CoI2), manganese and an N‐heterocyclic carbene (IPr) generated in situ from the corresponding imidazolium salt and butyllithium (BuLi). Polycyclic cyclohexadienes are obtained selectively. This new method represents an interesting alternative to those employing air‐sensitive cyclopentadienylcobalt [CpCoL2 (L=CO, C2H4)] catalysts. Moreover, the N‐heterocyclic carbene can be used catalytically, which is a significant improvement compared to the corresponding phosphine‐based system which requires an excess of ligand.
Prevalence and risk of asthma symptoms among firefighters in São Paulo, Brazil: A population‐based study
Authors: Ribeiro Marcos , de Paula Santos Ubiratan , Bussacos Marco Antonio , Terra‐Filho Mario 
Published: December 2008

AbstractThe firefighters are at increased risk of respiratory disease as a result of exposure to smoke and dust. The aim of this study was to determine the prevalence and risk associated with respiratory symptoms among city firefighters in São Paulo, Brazil.MethodsA cross‐sectional study utilizing the European Community Respiratory Health Survey (ECRHS) questionnaire was administered to firefighters and police officers, in order to evaluate their respiratory symptoms.ResultsComplete respiratory data were obtained from 1,235 firefighters and 1,839 police officers. Among the firefighters, there were 55.5% never‐smokers, 22.4% current smokers and 18.2% former smokers (P < 0.05). Among the police officers, there were 63.4%, 18.6%, and 9.6% who were never‐smokers, current smokers and former smokers (P < 0.05), respectively. Compared to police, firefighters experienced an increase in wheezing [OR = 1.63 (95% CI: 1.43–1.87)], wheezing with breathlessness [OR = 1.34 (95% CI: 1.10–1.64)], wheezing without a cold [OR = 1.60 (95% CI: 1.32–1.95)], waking with tightness in the chest [OR = 1.20 (95% CI: 1.02–1.42)], and rhinitis [OR = 1.12 (95% CI: 1.03–1.22)]. The prevalence of adult‐onset asthma in never‐smokers was 9.3% and 6.7% for firefighters and police officers [OR = 1.23 (95% CI: 1.01–1.56)]. An independent association was observed between years employed, smoking, history of rhinitis, and work as a firefighter and respiratory and nasal symptoms. We observed a high prevalence of asthma‐like symptoms in firefighters who presented respiratory symptoms beginning immediately after firefighting.ConclusionThese results suggest that the prevalence of respiratory symptoms and asthma in firefighters is higher than those in police officers. Work‐as a firefighter, rhinitis and years employed were risk factors for respiratory symptoms of asthma. Am. J. Ind. Med. 52:261‐269, 2009. © 2008 Wiley‐Liss, Inc.
Nichtlineare Effekte in der asymmetrischen Katalyse
Authors: Satyanarayana Tummanapalli , Abraham Susan , Kagan Henri B. 
Published: December 2008

AbstractZahlreiche Anwendungen in der Chemie erfordern die Synthese enantiomerenreiner Verbindungen. Einen effizienten Ansatz hierfür bietet die asymmetrische Katalyse. Hierbei wird der chirale Katalysator gewöhnlich aus einem chiralen Auxiliar erzeugt, das z. B. von einem Naturstoff abgeleitet wurde oder aus der Racematspaltung racemischer Vorstufen stammt. Die Verwendung nicht‐enantiomerenreiner chiraler Auxiliare in der asymmetrischen Katalyse scheint aus präparativer Sicht ungünstig, da man erwarten sollte, dass der Enantiomerenüberschuss (ee) des Reaktionsprodukts zum ee‐Wert des chiralen Auxiliars proportional ist (Linearität). Tatsächlich kann es jedoch zu Abweichungen von der Linearität kommen. Derartige nichtlineare Effekte können sehr aufschlussreich für den Mechanismus einer Reaktion sein und außerdem in der Synthesechemie genutzt werden (asymmetrische Verstärkung). Dieser Aufsatz fasst die Fortschritte der letzten zehn Jahre bei der Anwendung des nichtlinearen Effekts in der metallorganischen und organischen Katalyse zusammen.
Nonlinear Effects in Asymmetric Catalysis
Authors: Satyanarayana Tummanapalli , Abraham Susan , Kagan Henri B. 
Published: December 2008

AbstractThere is a need for the preparation of enantiomerically pure compounds for various applications. An efficient approach to achieve this goal is asymmetric catalysis. The chiral catalyst is usually prepared from a chiral auxiliary, which itself is derived from a natural product or by resolution of a racemic precursor. The use of non‐enantiopure chiral auxiliaries in asymmetric catalysis seems unattractive to preparative chemists, since the anticipated enantiomeric excess (ee) of the reaction product should be proportional to the ee value of the chiral auxiliary (linearity). In fact, some deviation from linearity may arise. Such nonlinear effects can be rich in mechanistic information and can be synthetically useful (asymmetric amplification). This Review documents the advances made during the last decade in the use of nonlinear effects in the area of organometallic and organic catalysis.
“If Pigs Could Fly” Chemistry: A Tutorial on the Principle of Microscopic Reversibility
Authors: Blackmond Donna G. 
Published: December 2008

AbstractThrough a glass darkly: Several recent autocatalytic reaction models for the origin of homochirality have suggested ways in which one enantiomer of the product might be reconverted into the other by a recycling reaction in a closed system. These models are revealed to violate the principle of microscopic reversibility, a powerful tool for assessing the plausibility of proposed reaction networks even at far‐from‐equilibrium conditions.magnified image
A Light‐Resistant Organic Sensitizer for Solar‐Cell Applications
Authors: Yum Jun‐Ho , Hagberg Daniel P. , Moon Soo‐Jin , Karlsson Karl Martin , Marinado Tannia , Sun Licheng , Hagfeldt Anders , Nazeeruddin Mohammad K. , Grätzel Michael 
Published: December 2008

AbstractFinely tuned: A stable dye‐sensitized solar cell that contains a molecularly engineered organic dye has been prepared. The efficiency of the cell remains at 90 % after 1000 h of light soaking at 60 °C. The remarkable stability of the cell is also reflected in the open‐circuit voltage value (Voc), short‐circuit photocurrent‐density value (Jsc), and the fill factor, which also show barely no decline (see picture).magnified image
Synthetic Lectins
Authors: Kubik Stefan 
Published: December 2008

AbstractImproving on Mother Nature? The carbohydrate recognition demonstrated by supramolecular systems in water can now compete with that of natural systems, both in terms of affinity and selectivity. A synthetic carbohydrate receptor displays similar affinity for N‐acetyl‐D‐glucosamine derivatives as the lectin wheat germ agglutinin and even greater selectivity (see picture: gray C, white H, blue N, red O).magnified image
Synthesis and characterizations of N,N′‐bis(diphenylphosphino)‐2‐(aminomethyl)aniline derivatives: application of a palladium(II) complex as pre‐catalyst in Heck and Suzuki cross‐coupling reactions
Authors: Aydemir Murat , Baysal Akın , Öztürk Gülşen , Gümgüm Bahattin 
Published: December 2008

AbstractThe reaction of 2‐(aminomethyl)aniline with 2 equivalents of PPh2Cl in the presence of Et3N, proceeds in CH2Cl2 to give N,N′‐bis(diphenylphosphino)‐2‐(aminomethyl)aniline 1 in good yield. Oxidation of 1 with aqueous H2O2, elemental sulfur or gray selenium gave the corresponding oxide, sulfide and selenide dichalcogenides [Ph2P(E)NHC6H4CH2NHP(E)Ph2] (E: O, 2a; S, 2b; Se, 2c), respectively. The reaction of [Ph2PNHC6H4CH2NHPPh2] with PdCl2(cod), PtCl2(cod) and [Cu(MeCN)4]PF6 gave the corresponding chelate complexes, PdCl21, PtCl21 and [Cu(1)2]PF6. The new compounds were fully characterized by NMR, IR spectroscopy and elemental analysis. The catalytic activity of the Pd(II) complex was tested in the Suzuki coupling and Heck reactions. The Pd(II) complex catalyzes the Suzuki coupling and Heck reaction, affording biphenyls and stilbenes respectively, in good yields. Copyright © 2009 John Wiley & Sons, Ltd.
Influence of the surface modification of a filler on the properties of high‐impact polystyrene composites
Authors: Wenguang Cui , Yanlei Gao , Qing Wei , Wei Mu 
Published: December 2008

AbstractA novel technique of surface modification was used to treat nanomodified aluminum trihydrate (nano‐CG‐ATH). The results of the surface modification were characterized with transmission electron microscopy and Fourier transform infrared spectra. The effects of the surface modification on the properties of high‐impact polystyrene (HIPS) composites were studied with limiting oxygen index (LOI) and mechanical tests. The dispersion of nano‐CG‐ATH in the HIPS matrix and the interfacial adhesion between them were observed with transmission electron microscopy and scanning electron microscopy. The experimental results demonstrate that the surface of nano‐CG‐ATH was successfully grafted by an organic substance, and the dispersion of treated nano‐CG‐ATH in ethanol was better than that of untreated nano‐CG‐ATH. At high loadings, the mechanical properties and LOI values of the HIPS composites with treated nano‐CG‐ATH were higher than those of the HIPS composites with untreated nano‐CG‐ATH. The dispersion of treated nano‐CG‐ATH in the HIPS matrix was better than that of untreated nano‐CG‐ATH in the HIPS matrix. Also, the interfacial adhesion between the HIPS matrix and treated nano‐CG‐ATH was better than that between the HIPS matrix and untreated nano‐CG‐ATH. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2009
B‐staged epoxy/single‐walled carbon nanotube nanocomposite thin films for composite reinforcement
Authors: Warren Graham L. , Sun Luyi , Hadjiev Viktor G. , Davis Daniel , Lagoudas Dimitris , Sue Hung‐Jue 
Published: December 2008

AbstractB‐staged epoxy/single‐walled carbon nanotube (SWCNT) nanocomposite thin films at 50% cure were prepared to improve the conductivity and mechanical performance of laminated composites. The SWCNTs were functionalized by oxidation and subsequent grafting with polyamidoamine generation‐zero dendrimers. The epoxy nanocomposites containing SWCNTs were successfully cast into thin films by the manipulation of the degree of cure and the viscosity of the epoxy. Raman microscopy characterization revealed that the thin films exhibited a high degree of SWCNT dispersion in the epoxy. The B‐staged thin films were seamlessly integrated into laminated composite systems upon heating and could serve as interleaves to improve the conductivity and mechanical strength of laminated fiber composite systems. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2009
Characterization of flexible polyurethane foams based on soybean‐based polyols
Authors: Das Sudipto , Dave Mahendra , Wilkes G. L. 
Published: December 2008

AbstractTwo series of flexible polyurethane foams were fabricated by substituting conventional petroleum‐based polyols with increasing amounts of soy‐based polyols (SBP) having different hydroxyl numbers. The mechanical properties of the foams were characterized by stress–strain analysis in the compression mode and DMA in tension mode, the cellular morphology was analyzed by SEM and the microphase‐separation of the foams was noted by SAXS. Our results showed that the cellular morphology and mechanical properties of the flexible foams were affected significantly by the foam fabrication method and SBP hydroxyl numbers. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2009