bluuebunny/crossref_metadata_2025_split huggingface dataset:
Organization of student teamwork using interactive Trello technologies in order to effectively use educational resources and improve literary competencies
Authors: Yengsebay G.Y. , Demchenko A.S. 
Published: February 2024

This article considers the possibility of applying a team style of training based on the method of training cases using the Trello web-service based on the Japanese Kanban system. We study the possibility of involving university students in joint work on large projects using the Trello web service to teach teamwork skills and parallel independent search for resources and a creative approach to solving the tasks set by the teacher. From this point of view, the author's study takes place through different levels of text analysis on the example of V. Astafyev's stories “The Autumn Sorrows and Joys” and “The Last Bow”, and sets the prospect of studying other types oftexts, “Dreams of the Cursed” by A. Zhaksylykov and “The School for Fools” by Sasha Sokolov. A comprehensive approach to the study of the text makes it possible to develop the literary competencies of students, fill the maximum lacunae in knowledge, and attract each student to work in the project.
Формирование тезауруса языковой личности будущего специалиста-филолога с позиций лингводидактики
Authors: Саяхмет С.С. , Туманова А.Б. 
Published: February 2024

Статья посвящена проблеме формирования языковой личности специалиста в условиях модернизации системы образования на современном этапе. В ней изложен краткий обзор научной информации о толковании данного феномена и ее структуры; представлено свое понимание профессиональной языковой личности филолога. Цель — попытка наметить пути формирования языковой личности будущего специалиста-филолога, в частности, его тезауруса. Рассмотрено понятие «профессиональная языковая личность» с позиций лингводидактики. На основе сравнительно-сопоставительного, контекстологического, описательного методов авторами проанализированы образовательные программы бакалавриата филологического факультета Казахского национального университета им. Аль-Фараби «Русский язык и литература». Разработано и проведено анкетирование студентов на знание ими узкоспециальных терминов по направлению «Русский язык» на стартовом, промежуточном и итоговом этапах обучения. Для обоснования полученных результатов исследования и их интерпретации использован количественно-статистический подсчет. Для формирования и совершенствования тезауруса (как отдельного компонента ЯЛ) специалиста-филолога авторами предложено несколько путей: систематизация и комплексность в подаче и усвоении программного материала, разработка системы заданий и упражнений, ролевых игр, повышение мотивации у обучающихся к профессиональному росту. Данная методика может быть применена в процессе формирования тезауруса в рамках любого языка.
Профессиональный социолект как социально-детерминированная подсистема литературного языка
Authors: Тулегенова М.К. , Жунусова Ж.Н. , Вальтер Х. 
Published: February 2024

Оригинальность статьи проявляется в том, что в ней по-новому осуществляется подход к выявлению особенностей профессионального социолекта, детерминированного разнообразными социальными факторами, рассматриваются их виды и соответствующие им языковые варианты. В центре исследования — специализированная подсистема языка социально парциальной группы говорящих в их профессиональной сфере деятельности, которая используется в соответствии с ситуационными переменными: социальная роль, социальные отношения. Содержание работы составили сведения,касающиеся выделения языкового варианта, — профессионального социолекта, имеющего следующие социальные признаки: детерминированность стратификационными, ситуативными и коммуникативными переменными (адресат, адресант, цель речевого акта, цель коммуникации и др.); использование профессионалами рече-языковых вариантов в акте коммуникации, в речевой деятельности коммуникантов в ходе специализированной деятельности в виде языкового кода, отражающего специфику деятельности говорящих и фиксирующего их профессиональный опыт; выделение парциальных групп и социальных факторов; характеристика профессиональной лексики исследуемого социолекта. Авторами дано представление дифференциации языка; охарактеризованы социальные факторы, детерминирующие социолекты на современном уровне развития языка; рассмотрено использование языковых профессиональных вариантов с социальными детерминантами; описаны страты общества и изучены парциальные группы; установлено, что профессиональный социолект — это вариант языка, детерминированный социальными опосредованными факторами: стратификационными, ситуативными и коммуникативными. В целом, профессиональный социолект представлен как вариант языка, обусловленный стратификационными, ситуативными и коммуникативными социальными факторами.
Gambaran Pengetahuan Ibu Hamil Tentang Hiperemesis Gravidarum pada Trimester I Kehamilan
Authors: Marpaung Ayesha Nazira , Rivany Riza , Tobing Tina Christina L. , Ketaren Andre Pasha 
Published: February 2024

Background: Nausea and vomit are problems that often occur in the first trimester of pregnancy, and this can cause problems for pregnant women. Many people still have the perception that this is a normal occurrence, leading pregnant women to avoid medical examinations, resulting in potential side effects. This relates to the knowledge. Pregnant women with poor knowledge can lead to complications during pregnancy, while those with good knowledge will prevent complications. Objective: To describe pregnant women’s knowledge about hyperemesis gravidarum in the first trimester of pregnancy based on age, gravida, and academic. Methods: This research is an observational descriptive study with a cross-sectional research design, employing consecutive sampling method. Data were collected using primary data sources derived from questionnaire responses. Results: Based on data from 100 respondents, 28 people (28%) have good knowledge. 27 people (27%) have moderate knowledge. 45 people (45%) have poor knowledge. Conclusion: Most of pregnant women in this research belonged to the age group of 19-34 years, with primigravida and majority have poor knowledge.
Keyword: Hyperemesis gravidarum, knowledge, pregnant women

Latar Belakang: Mual dan muntah merupakan masalah yang sering terjadi pada trimester pertama kehamilan dan hal ini dapat menimbulkan masalah pada ibu hamil. Masih banyak masyarakat yang memiliki pandangan bahwa hal tersebut normal terjadi, sehingga ibu hamil tidak melakukan pemeriksaan dan akan menimbulkan efek samping. Hal ini berkaitan dengan pengetahuan yang dimiliki oleh ibu hamil. Ibu hamil yang memiliki pengetahuan yang kurang terhadap hiperemesis gravidarum menyebabkan terjadinya komplikasi pada ibu hamil, sedangkan ibu hamil dengan pengetahuan yang baik akan mencegah terjadinya komplikasi. Tujuan: Untuk mengetahui tingkat pengetahuan ibu hamil terhadap hiperemesis gravidarum pada trimester I kehamilan berdasarkan usia, pendidikan terakhir dan gravida. Metode: Penelitian ini adalah penelitian deskriptif observasional dengan desain penelitian cross sectional. Pengambilan sampel dengan consecutive sampling. Data yang diambil menggunakan sumber data primer yang berasal dari pengisian kuesioner. Hasil: Berdasarkan data yang diperoleh dari 100 responden terdapat 28 orang (28%) memiliki pengetahuan baik. 27 orang (27%) memiliki pengetahuan cukup. 45 orang (45%) memiliki pengetahuan kurang. Kesimpulan: Mayoritas ibu hamil pada penelitian ini merupakan kelompok usia 19-34 tahun, dengan primigravida, dan mayoritas memiliki pengetahuan yang kurang.
Kata Kunci: Hiperemesis gravidarum, ibu hamil, pengetahuan
PEMANFAATAN LIMBAH CANGKANG KELAPA SAWIT PADA CAMPURAN BETON RINGAN
Authors: Indrayani Indrayani , Sulianti Ika , Wahyudi Wahyudi , Herbi Bahusin Aji Jaya 
Published: February 2024

Berbagai macam bahan tambah telah sering dilakukan dalam upaya peningkatan mutu beton agar semakin tinggi dengan memanfaatkan bahan-bahan alternatif yang mudah didapat sehingga pembuatan beton menjadi ekonomis. Penelitian ini memanfaatkan limbah cangkang kelapa sawit pada campuran beton ringan, dimana cangkang kelapa sawit digunakan sebagai pengganti agregat kasar baik sebagian maupun keseluruhan dengan tujuan untuk mendapat pengaruh cangkang kelapa sawit pada pembuatan beton ringan, agregat kasar dengan cangkang kelapa sawit yang diharapkan dengan pemanfaatan limbah cangkang sawit ini akan mampu meningkatkan kuat tekan beton. Proses penggantian cangkang kelapa sawit ini yaitu dengan cara perhitungan terhadap volume agregat kasar. Variasi persentase cangkang kelapa sawit terhadap volume agregat kasar di dalam campuran adalah cangkang kelapa sawit 25%, cangkang kelapa sawit 50%, cangkang kelapa sawit 75% dan cangkang kelapa sawit 100%. Waktu pengujian kuat tekan beton dilakukan pada umur 14 dan 28 hari berdasarkan SNI 03-2491-2002. Dari hasil pengujian kuat tekan beton pada umur 28 hari diperoleh rata-rata sebesar 23.86 Mpa. Sedangkan hasil pengujian kuat tekan beton pada umur 28 hari menggunakan cangkat sawit pada variasi 25%, 50%, 75%, dan 100% memiliki nilai kuat tekan rata-rata sebesar 14,9 MPa, 11,6 MPa, 4,25 MPa, dan 2,73 MPa. Pada variasi 25% didapat kuat tekan beton sebesar 14,9 MPa, ini menunjukan bahwa cangkang kelapa sawit masih dapat digunakan sebagai campuran pada beton non struktural.
SISTEM ANTRIAN UNTUK MENGANALISIS PENGOPTIMALAN PELAYANAN PENGAMBILAN OBAT DI PUSKESMAS BANABUNGI KECAMATAN PASARWAJO KABUPATEN BUTON
Authors: Restayani  , Arman  , Jufra  , Somayasa Wayan , Budiman Herdi , Muhtar Norma 
Published: February 2024

Puskesmas ialah suatu instansi di mana sangat berperan untuk melayani masyarakat yang harus memberikan pelayanan terbaik. Terdapat pasien per harinya sehingga dapat mengakibatkan antrian yang panjang dalam melayani pasiennya. Antrian adalah keadaan di mana sekumpulan orang yang membutuhkan pelayanan harus menunggu dalam suatu urutan baris tertentu sebelum memperoleh pelayanan. Hal ini disebabkan oleh kemampuan memberikan pelayanan lebih kecil bila dibandingkan dengan kebutuhan akan suatu pelayanan. Tujuan penelitian ini untuk menganalisis dalam upaya mengoptimalkan sistem pelayanan dan untuk mengetahui kinerja sistem pelayanan pengambilan obat. Metode penyelesaian yang digunakan adalah metode observasi dengan model sistem ( . Penelitian dilakukan selama 5 hari pada hari senin-jumat bulan April tahun 2022. Data yang diambil adalah waktu antar kedatangan dan waktu pelayanan sehingga dari data tersebut diperoleh hasil ukuran kinerja dari disiplin antrian yaitu nilai utilitas sistem sebesar , rata-rata jumlah pasien dalam sistem sebesar pasien, rata-rata jumlah pasien yang menunggu dalam antrian sebesar 0,168 pasien, rata-rata waktu yang dihabiskan seorang pasien dalam sistem sebesar per jam, dan rata-rata waktu yang dihabiskan seorang pasien dalam antrian sebesar per jam. Sistem antrian yang diterapkan Puskesmas Banabungi Kecamatan Pasarwajo Kabupaten Buton sudah optimal karena antrian tidak cukup panjang
Effect of Simulated Gastric Juice on Color Stability of Different Artificial Teeth
Authors: Yılmaz Evmek Betül , Yeğin Elif 
Published: February 2024

Objective: The current study aimed to evaluate the gastric juice effect on the artificial teeth discoloration in patients with gastroesophageal reflux disease (GERD) under in vitro conditions.
Methods: Three different artificial teeth (Ivostar, Vivodent PE, Phonares II) were used in the study (n=12). A spectrophotometer (VITA Easyshade Compact; VITA Zahnfabrik, Bad Säckingen, Germany) was used for initial color measurements after keeping the specimens in distilled water for 24 h. Then, they were immersed in 5% hydrochloric acid (HCl) at 37°C (pH=2) for 91 h and the color measurements were
repeated. The CIEDE2000 formulation was used to calculate the color changes. The statistical analysis was performed with one-way ANOVA and Tukey HSD tests.
Results: Although the color differences of Vivodent PE and Phonares II materials did not exhibit a statistically significant difference (p=.95; p > .05), there was a significant difference between Ivostar and other materials (p=.02, p=.01). The 50:50% detection threshold (PT) was exceeded with Vivodent PE and Phonares II materials, while the 50:50% acceptability threshold (AT) was exceeded with Ivostar material.
Conclusion: After exposure to gastric acid, all groups exhibited perceptible color differences. In the group of acrylic resin artificial teeth, the color difference was above acceptability threshold and would be better to improve. While the acrylic resin artificial teeth exhibited the highest discoloration, artificial teeth containing nanohybrid composite resin showed the least discoloration. These should be considered in
the selection of artificial teeth in patients with GERD.
Modelagem e análise molecular da enzima Adenosina Desaminase (ADA) do parasito Schistosoma mansoni
Authors: Kayser Danrlei Leandro , Vicente de Lima Cassiano , Lorscheider Carla Andreia , Romanello Larissa 
Published: February 2024

A esquistossomose é uma doença parasitária provocada pelo helminto Schistosoma mansoni e afeta cerca de 240 milhões de pessoas em todo mundo. O tratamento da doença atualmente dá-se pela administração de apenas um fármaco, o praziquantel entretanto, pelo seu uso em massa, diversos casos de resistência do parasita ao fármaco tem sido reportados. Diferente de seu hospedeiro humano, o S. mansoni não possui a via de síntese de purinas, dependendo exclusivamente da via de salvação de purinas para o suprimento dessas bases. Deste modo esta via tem sido citada como alvo potencial para o desenvolvimento de novos fármacos contra a esquistossomose. A adenosina desaminase (ADA) é uma das enzimas dessa via, convertendo a adenosina em inosina e hipoxantina. Uma vez que a estrutura tridimensional dessa enzima não foi resolvida experimentalmente, a modelagem molecular comparativa possibilitou a análise molecular e bioquímica. O estudo foi desenvolvido em etapas: seleção do molde, alinhamento alvo-molde, construção do modelo molecular, avaliação e validação do modelo, análises moleculares. As avaliações do modelo obtido apresentaram qualidade satisfatória e, em comparação com ADA humana foi possível observar substituições de resíduos de aminoácidos no sítio ativo que suportam a investigação da enzima como alvo potencial para desenvolvimento de fármacos através de experimentos de docagem, cinética enzimática e cristalografia de proteínas.
Inactivation of SARS CoV-2 on porous and nonporous surfaces by compact portable plasma reactor
Authors: Choudhury Bhaswati , Lednicky John A. , Loeb Julia C. , Portugal Sherlie , Roy Subrata 
Published: February 2024

We report the inactivation of SARS CoV-2 and its surrogate—Human coronavirus OC43 (HCoV-OC43), on representative porous (KN95 mask material) and nonporous materials (aluminum and polycarbonate) using a Compact Portable Plasma Reactor (CPPR). The CPPR is a compact (48 cm3), lightweight, portable and scalable device that forms Dielectric Barrier Discharge which generates ozone using surrounding atmosphere as input gas, eliminating the need of source gas tanks. Iterative CPPR exposure time experiments were performed on inoculated material samples in 3 operating volumes. Minimum CPPR exposure times of 5–15 min resulted in 4–5 log reduction of SARS CoV-2 and its surrogate on representative material samples. Ozone concentration and CPPR energy requirements for virus inactivation are documented. Difference in disinfection requirements in porous and non-porous material samples is discussed along with initial scaling studies using the CPPR in 3 operating volumes. The results of this feasibility study, along with existing literature on ozone and CPPR decontamination, show the potential of the CPPR as a powerful technology to reduce fomite transmission of enveloped respiratory virus-induced infectious diseases such as COVID-19. The CPPR can overcome limitations of high temperatures, long exposure times, bulky equipment, and toxic residuals related to conventional decontamination technologies.
The impact of three SMN2 gene copies on clinical characteristics and effect of disease-modifying treatment in patients with spinal muscular atrophy: a systematic literature review
Authors: Dosi Claudia , Masson Riccardo 
Published: February 2024

ObjectiveTo review the clinical characteristics and effect of treatment in patients with spinal muscular atrophy (SMA) and three copies of the SMN2 gene.MethodsWe conducted a literature search in October 2022 to identify English-language clinical research on SMA that included SMN2 copy number according to PRISMA guidelines.ResultsOur search identified 44 studies examining the impact of three SMN2 copies on clinical characteristics (21 on phenotype, 13 on natural history, and 15 on functional status and other signs/symptoms). In children with type I SMA or presymptomatic infants with an SMN1 deletion, three SMN2 copies was associated with later symptom onset, slower decline in motor function and longer survival compared with two SMN2 copies. In patients with SMA type II or III, three SMN2 copies is associated with earlier symptom onset, loss of ambulation, and ventilator dependence compared with four SMN2 copies. Eleven studies examined treatment effects with nusinersen (nine studies), onasemnogene abeparvovec (one study), and a range of treatments (one study) in patients with three SMN2 copies. In presymptomatic infants, early treatment delayed the onset of symptoms and maintained motor function in those with three SMN2 copies. The impact of copy number on treatment response in symptomatic patients is still unclear.ConclusionSMN2 copy number is strongly correlated with SMA phenotype in patients with SMN1 deletion, while no correlation was found in patients with an SMN1 mutation. Patients with three SMN2 copies show a highly variable clinical phenotype. Early initiation of treatment is highly effective in presymptomatic patients with three SMN2 copies.
Isolated insular stroke: topography is the answer with respect to outcome and cardiac involvement
Authors: Kuris Fedra , Tartaglia Sara , Sperotto Roberto , Ceccarelli Laura , Bagatto Daniele , Lorenzut Simone , Merlino Giovanni , Janes Francesco , Gentile Carolina , Marinig Roberto , Verriello Lorenzo , Valente Mariarosaria , Pauletto Giada 
Published: February 2024

Background and purposeIsolated insular strokes (IIS) are a rare occurrence due to the frequent concomitant involvement of adjacent territories, supplied by the M2 segment of the middle cerebral artery (MCA), and clinical aspects are sometimes contradictory. We aimed to describe clinical and radiological characteristics of a pure IIS case series, focusing on its functional outcome and cardiac involvement.MethodsWe identified 15 isolated insular ischemic strokes from a pool of 563 ischemic strokes occurred between January 2020 and December 2021. Data collection consisted of demographic and baseline clinical characteristics, comorbidities, electrocardiograms, echocardiograms, stroke topography and etiology, reperfusive treatments, and outcome measures. Descriptive statistical analysis was carried out.ResultsNewly detected cardiovascular alterations were the prevalent atypical presentation. Cardioembolism was the most frequent etiology. Most of patients had major neurological improvement at discharge and good outcome at 3-months follow-up.Discussion and conclusionIIS are extremely rare, representing according to our study about 2.6% ischemic strokes cases per year, and patients have peculiar clinical manifestations, such as dysautonomia and awareness deficits. Our data suggest the possibility for these patients to completely recover after acute ischemic stroke notwithstanding the pivotal role of the insula in cerebral connections and the frequent association with MCA occlusion. Moreover, given the central role of the insula in regulating autonomic functions, newly detected cardiac arrhythmias must be taken into consideration, as well as a full diagnostic work-up for the research of cardioembolic sources. To our knowledge, this is the largest monocentric case series of IIS and it might be useful for future systematic reviews.
MicroRNA as a potential diagnostic and prognostic biomarker in brain gliomas: a systematic review and meta-analysis
Authors: Hasani Fatemeh , Masrour Mahdi , Jazi Kimia , Ahmadi Payam , Hosseini Saba sadat , Lu Victor M. , Alborzi Amirmohammad 
Published: February 2024

IntroductionBrain neoplasms and central nervous system (CNS) disorders, particularly gliomas, have shown a notable increase in incidence over the last three decades, posing significant diagnostic and therapeutic challenges. MicroRNAs (miRNAs) have emerged as promising biomarkers due to their regulatory role in gene expression, offering potential enhancements in glioma diagnosis and prognosis.MethodsThis systematic review and meta-analysis, adhering to PRISMA guidelines, included 25 studies for diagnostic accuracy and 99 for prognostic analysis, published until August 27th, 2023. Studies were identified through comprehensive searches of PubMed, Web of Science, and Scopus databases. Inclusion criteria encompassed peer-reviewed original research providing sensitivity, specificity, and area under the curve (AUC) for miRNAs in glioma diagnosis, as well as survival outcomes with hazard ratios (HRs) or mean survival.Results and discussionMeta-analysis demonstrated miRNAs’ high diagnostic accuracy, with a pooled sensitivity of 0.821 (95% CI: 0.781–0.855) and specificity of 0.831 (95% CI: 0.792–0.865), yielding an AUC of 0.893. Subgroup analysis by specimen type revealed consistent accuracy across blood, cerebrospinal fluid (CSF), and tissue samples. Our results also showed miRNAs can be potential prognostic biomarkers. miRNAs showed significant associations with overall survival (OS) (pooled HR: 2.0221; 95% CI: 1.8497–2.2105), progression-free survival (PFS) (pooled HR: 2.4248; 95% CI: 1.8888–3.1128), and disease-free survival (DFS) (pooled HR: 1.8973; 95% CI: 1.1637–3.0933) in tissue specimens. These findings underscore miRNAs’ potential as valuable biomarkers for improving glioma diagnosis and prognosis, offering insights for enhancing clinical decision-making and patient outcomes.