bluuebunny/crossref_metadata_2025_split huggingface dataset:
Graph Neural Networks for Multi-modal Recommendation: A Bipartite Heterogeneous Approach
Authors: Patel Aarav , Hayes Kellan , Watson Kade 
Published: March 2024

Abstract
In the era of big data and information technology, the exponential growth in data volume has significantly enriched people's lives, meeting their ever-expanding needs. However, this deluge of data has also led to a proliferation of invalid information, posing a considerable challenge in people's daily lives. Graph data has emerged as a focal point in data mining research, offering a powerful framework for organizing and analyzing complex relationships within datasets. Graphs, comprised of nodes and edges, serve as versatile structures for representing diverse datasets. This paper proposes the use of graph neural network techniques to address the challenging cold start problem while preserving the model's ability to capture and understand node content features. In recommender systems, the user-item interaction graph typically takes the form of a bipartite heterogeneous graph, where user nodes and item nodes belong to distinct domains, each with potentially different initial feature dimensions. This inherent heterogeneity necessitates the development of specialized techniques tailored to bipartite heterogeneous graph inference. The paper presents a recommendation method based on graph neural networks and driven by the attention mechanism. By incorporating multidimensional representation vectors of users, items, and ratings, the proposed approach aims to improve recommendation quality, particularly when dealing with sparse rating matrices. Additionally, we introduce subgraph extraction to diversify training graph topology by sampling subgraphs from large graphs. Experimental results demonstrate that the recommendation model proposed in this paper outperforms several mainstream baselines while effectively addressing the cold start problem.
Synthesis, spectral characterizations and in silico study of some 2-amino-4,6-diarylpyrimidines derived from chalcones
Authors: Aiwonegbe Anthony E. , Iyasele  , Usifoh  
Published: March 2024

Abstract
Four 2-amino-4,6-diarylpyrimidines were synthesized from their respective 1,3-diphenylprop-2-en-1-one (chalcone) precursors. The chalcones were condensed with guanidine carbonate by refluxing in dimethylformamide for 4 hours at 140°C to obtained the title compounds: 4,6-Diphenyl-pyrimidin-2-ylamine (PAA1), 4-(4-Nitro-phenyl)-6-phenyl-pyrimidin-2-ylamine (PAA2), 4-Phenyl-6-(3,4,5-trimethoxy-phenyl)pyrimidin-2-ylamine (PAA3) and 4-Phenyl-6-(3,4,5-trimethoxy-phenyl)pyrimidin-2-ylamine (PAA4). TLC was used to ascertain the purity of the synthesized compounds and their melting points were determined using the open capillary method. They were characterized using IR, 1H-NMR, 13C-NMR and GC-MS. Biological activities of the title compounds were predicted using Gaussian 16 software suite36 (for full geometry optimization in chloroform and gas phase) and SwissADME web tool for the lipophilicity and hydrophylicity. The compounds were obtained in good yield and the characteristic N-H stretch of the -NH2 group (free and H-bonded) was observed at 3503, 3380 cm-1(PAA1); 3492, 3317 cm-1(PAA2); 3194,3309 cm-1 for (PAA3) and 3466, 3313 cm-1(PAA4). The logP values revealed that the lipophilicity of the compounds is in the order: PAA1< PAA2< PAA3< PAA4. The computations on the optimized geometry established the possible application of the compounds in the synthesis of modern pharmaceuticals.
Herbal Treatments for Obesity: A Review
Authors: Gasmi Amin , Noor Sadaf , Mujawdiya Pavan Kumar , Akram Muhammad , Manzoor Aisha , Bjørklund Geir 
Published: March 2024

Abstract:
Obesity is the most pervasive metabolic disorder, further linked with many
other diseases, including diabetes, hypertension, cardiovascular disorders, and sleep apnea.
To control the increasing weight of obese individuals, experts usually recommend
exercise and lifestyle alterations, but medication and surgeries are also advised in severe
cases. FDA-approved obesity-controlling drugs are effective but possess certain adverse
effects, including dry mouth, drug abuse, dysregulation in monoamine neurotransmitters,
insomnia, and many more. Medication processes are expensive; researchers have focused
on safer and more effective alternative approaches than pharmaceutical drugs.
Since ancient times, a diverse array of herbal plants have been used due to their therapeutic
effect, as in-vitro and in-vivo experimentations have proved the effectiveness of herbal
plants with no mortality. In this review, we have presented various herbs with their
metabolically active secondary metabolites, including Berberis vulgaris L, Rhizoma Coptidis,
Radix Lithospermi, Aloe vera, Clerodendrum multiflorum Burm f., Astragalus membranaceus
(Fisch), Boerhaavia diffusa, Achyranthes aspera L., etc. All of these herbs
are responsible for anti-obesity, anti-diabetic, and anti-inflammatory effects. Most of the
previously published clinical trials and animal studies that confirmed the significant potential
of these herbal plants and their active ingredients to reduce weight by decreasing
the accumulated fats in the body have also been discussed in this review. Thus, it is concluded
that scientists must consider and utilize these natural treasures for safe, effective,
and cost-effective treatment. It will open new and novel ways for treatment regimes.
Imidazo[1,2-A]Pyridine: Potent Biological Activity, SAR and Docking
Investigations (2017-2022)
Authors: Narayan Aditya , Patel Shivkant , Baile Sunil B. , Jain Surabhi , Sharma Smriti 
Published: March 2024

Background:
Regarding scientific research, Imidazo[1,2-a] pyridine derivatives are constantly being developed due to the scaffold’s intriguing chemical structure and varied bio-logical activity. They are distinctive organic nitrogen-bridged heterocyclic compounds that have several uses in medicines, organometallics and natural products. It has become a vital tool for medicinal chemists.

Methods:
In order to gather scientific information on Imidazo[1,2-a] pyridines derivative, Google, PubMed, Scopus, Google Scholar, and other databases were searched. In the current study, the medicinal value and therapeutic effect of Imidazo[1,2-a] pyridines were investigated using above mentioned databases. The current study analyzed the detailed pharmacological ac-tivities of Imidazo[1,2-a] pyridine analogs through literature from diverse scientific research works.

Results:
Due to its wide range of biological activities, including antiulcer, anticonvulsant, anti-protozoal, anthelmintic, antiepileptic, antifungal, antibacterial, analgesic, antiviral, anticancer, anti-inflammatory, antituberculosis, and antitumor properties, imidazopyridine is one of the most significant structural skeletons in the field of natural and pharmaceutical products. An imidazopyridine scaffold serves as the basis for a number of therapeutically utilized medica-tions, including zolpidem, alpidem, olprinone, zolimidine, and necopidem.

Conclusion:
This comprehensive study covers the period of the last five years, and it sheds light on the developments and emerging pharmacological actions of Imidazo[1,2-a] pyridines. Additionally, the structure-activity relationship and molecular docking studies are carefully documented throughout the paper, providing medicinal chemists with a clear picture for devel-oping new drugs.
Recent Advances in Orally Disintegrating Tablet: Properties, Formulation and Production
Authors: Yee Kar Ming , Mohamad Najwa , Kee Phei Er , Chew Yik-Ling , Lee Siew-Keah , Lakshminarayanan Vijayakumar , Tan Ching Siang , Liew Kai Bin 
Published: March 2024

:
Healthcare practitioners, patients, and consumers widely recognize the convenience as-sociated with administering oral tablets. The emergence of orally disintegrating tablets (ODTs) represents a significant advancement in solid dosage forms, facilitating more convenient oral de-livery while maintaining medication safety, effectiveness, and quality. The ODTs market is ex-pected to experience continuous growth in the coming years despite the internal challenges faced by commercial manufacturers. This paper initiates a comprehensive discussion of the properties of ODTs, including palatability and taste, drug content, disintegration, mechanical strength, mois-ture content, safety, and efficacy. The formulation factors that affect each of these qualities are also discussed. Additionally, this review delves into the processes of the production of ODTs, en-compassing the approaches and technologies from the mixing of active ingredients and recipients to the formation and packaging of ODTs. This review provides valuable insights into the ad-vancement in ODTs technology, aiming to equip researchers with the knowledge necessary to improve quality and optimize efficiency, ultimately receiving high acceptance from patients or consumers.
PANDAS: Twenty-Five Years Later
Authors: Cardelle-Pérez Federico , Díaz-Caneja Greciano María Ángeles 
Published: March 2024

Background:
It has been 25 years since the definition of the concept
of Pediatric Autoimmune Neuropsychiatric Disorders Associated with
Streptococcal Infections (PANDAS). The abrupt onset of neuropsychiatric
symptoms requires a comprehensive differential diagnosis involving
complementary tests and optimal treatment selection.

Methods:
This paper describes aspects related to the diagnosis and clinical
management of PANDAS. A clinical perspective is developed starting from an
example that meets the Swedo's criteria.

Discussion:
A comprehensive approach, including interdisciplinary management
and urgent evaluation of potential organic causes, is crucial for effective
treatment. Treatment decisions should consider severity, symptoms, and available
evidence. Collaboration with neuropediatric or neurological services is needed.
ASLO/anti-DNase B and 25-OH-Vitamin D tests are valuable for atypical
OCD/Tic presentations, always maintaining a broader organic screening.
Pengaruh Optimisme Terhadap Kesejahteraan Subjektif pada Mahasiswa yang Mengerjakan Tugas Akhir
Authors: Dewanti Anin Ditha Putri , Ayriza Yulia 
Published: March 2024

Penelitian ini bertujuan untuk mengetahui pengaruh optimisme terhadap kesejahteraan subjektif pada mahasiswa yang mengerjakan tugas akhir di Fakultas Ilmu Pendidikan Universitas Negeri Yogyakarta. Pendekatan penelitian yang digunakan merupakan penelitian kuantatif dengan jenis penelitian ex-post facto. Sampel penelitian berjumlah 254 mahasiswa dengan kuesioner sebagai alat untuk mengumpulkan data. Skala yang digunakan merupakan skala optimisme dan skala kesejahteraan subjektif, dimana skala kesejahteraan subjektif terdiri dari subskala PANAS dan subskala kepuasan hidup. Validitas pada skala optimisme menggunakan validitas isi yang diuji melalui expert judgement, validitas faktorial subskala PANAS yakni antara 0,89-0,95; dan validitas konkuren subskala kepuasan hidup 0,73. Reliabilitas pada skala kesejahteraan subjektif adalah 0,814 dan reliabilitas skala optimisme adalah 0,823. Teknik analisis yang digunakan yaitu analisis regresi linier sederhana. Hasil penelitian menunjukkan bahwa terdapat pengaruh optimisme yang positif dan signifikan terhadap kesejahteraan subjektif (0,0000,05) dengan garis regresi yang didapatkan yakni Y = 33,631 + 0,901X. Dengan demikian dapat disimpulkan bahwa optimisme mampu memprediksi kesejahteraan subjektif mahasiswa yang mengerjakan tugas akhir. Kata Kunci: Kesejahteraan Subjektif; Mahasiswa yang Mengerjakan Tugas Akhir;Optimisme.
HYGINIE, SANITATION AND NUTRITION OF SNACKS IN THE CANTEEN
Authors: Rahayu Tutiek , Fauzan Aji Nur Nur , Pertiwi Kartika Ratna 
Published: March 2024

The purpose of this study was to determine the sanitation hygiene of the school canteen, the contribution of wet snack food to meeting the daily nutritional needs of students and to find out whether there were differences in sanitation and nutritional hygiene between wet snacks sold in the school canteen between Adiwiyata school canteens and non-Adiwiyata schools. This type of research is a descriptive observational research. The sample in this study is packaged and unpackaged snacks which are often sold in the school canteen. The variables in the study were the condition of the snacks in SD Adiwiyata and SD non-Adiwiyata in Bantul Regency. The standard instrument from the Indonesian Ministry of Health regarding hygiene, sanitation and nutritional content of food uses a computer application "nutry survey" and the E. coli test at the Microbiology Laboratory of the Faculty of Mathematics and Natural Sciences UNY. The result of the research is that the value of hygiene and sanitation of SD Adiwiyata canteen is 81.43% with good criteria, while non-Adiwiyata elementary school is 68.81% with moderate criteria. The average energy adequacy per day is 1461.6 kcal, while the recommended energy adequacy is 1594.5 kcal, thus only 92% fulfilled. There are differences in the hygiene and sanitation of wet snack food canteens between Adiwiyata and non-Adiwiyata elementary schools. Judging from the presence of E.coli and mold contamination, snacks in non-Adiwiyata school canteens showed that the number of E.coli and molds was higher than Adiwiyata Elementary School both in the morning and in the afternoon. Keywords : hygiene, sanitation, food nutrition, canteen
When should DIY have a localized healthcare waste management system?
Authors: Hasanbasri Mubasysyir , Sarto  , Wiranto  , Sutena Marthinus , Qaimamunazzala Hayu , Ferdiana Astri , Ramadona Aditya Lia , Jaladara Vena , Nilasari  , Meliala Andreasta , Padmawati Retna Siwi 
Published: March 2024

Purpose: The 2018 healthcare waste management crisis catalyzed a critical review of the concerns expressed by the Health Office (dinkes) and healthcare facilities regarding healthcare waste management in the Special Region of Yogyakarta (DIY). Due to this crisis, the Ministry of Health hired Universitas Gadjah Mada (UGM) to look into potential solutions and promote DIY government policy responses. This paper examines the management strategy during crisis times and possible alternative solutions.
Methods: This paper uses focused group discussions reports involving separate groups of (1) environmental health officials from community health centers, (2) hospitals, (3) environment health officials of district health authorities, and (4) cross-sectoral province officials in the Yogyakarta Special Region. It is part of a project 'A case study of strengthening regional-based medical waste management model', fund from the Environmental Health Directorate, Directorate General of Public Health, Ministry of Health (Project KN 01.03/6.1/0198/2019).
Result: A simulation of policy options based on health facility managers suggests that a province-based system is the most profitable in the long term for DIY, with several possible options. The national policy roadmap was considered inadequate to respond to DIY's urgent local needs. Furthermore, the series of meetings succeeded in forming an informal forum between health facilities, provincial health offices, and associations of hospital environmental sanitation experts, monitoring medical waste management.
Conclusion: The 2018 medical waste management crisis led to the formulation of policy response choices tailored to the capacity of DIY. These choices considered the expenditures and legal sanctions faced by healthcare facilities and the economic value of a region-based waste system for local government authorities. This comprehensive approach highlights the importance of local capacity. It needs to shape effective and sustainable medical waste management policies, underscoring the necessity of region-specific strategies in the face of national health crises.
Elderly care by village health volunteers during COVID-19 pandemic in Thailand
Authors: Sumiar Haening Ratna , Viwatpanich Kanvee 
Published: March 2024

Purpose: This study aimed to understand how village health volunteers (VHV) perform their duties and look after older adults during the COVID-19 pandemic health crisis.
Methods: We used in-depth interviews, group interviews, and observation to collect the data. This study was carried out in Wat Rong Lot, Chiang Rai, Thailand. Eleven people were involved in this research including one Public Health Department officer, Master of the Temple, five VHVs, one nurse, and three older adults in the community. We used content analysis to analyze our data.
Results: Before the pandemic, VHV’s duties included health screening and monitoring, reporting the results to the primary health center, and health education to the older adults in the community. During the pandemic, they perform these duties by making a monthly visit to conduct ADL and living arrangement assessment and drug delivery. Since the lockdown, many VHV duties must be shifted which resulted in pausing regular care plans for the elderly. However, VHVs keep delivering health services to the elderly by making home visits in case of an emergency, drug delivery, and donating masks and medical supplies. They were burdened with additional responsibilities related to COVID-19 prevention, detection, and surveillance. They admitted to facing some challenges such as being unconfident when performing their work and distrust from the community.
Conclusion: The additional responsibilities and lockdown hinder regular treatment. Further research is needed regarding the impact of care plan cessation for the elderly.
Adverse reactions following COVID-19 immunization in children of elementary school age
Authors: Yusuf Yenni , Junaedi Ari Andini , Mutmainnah  , Fadhilah Nur Azizah , Wahyuni Sitti 
Published: March 2024

Purpose: Due to the low rate of parent acceptance of vaccines, this study was conducted to evaluate post-vaccination adverse events among elementary school students.
Methods: This survey took place in the Manggala Subdistrict of Makassar City. The study was conducted from September to October 2022 by distributing a paper-based questionnaire regarding the COVID-19 vaccines.
Results: Of 129 respondents, the age range was 7-12 years. Sixty-five percent of respondents received the first vaccine shot in January or February, with a 4-week interval of the second dose among 46.5% of children. The vaccine administered was CoronaVac from Sinovac. The most common adverse events were injection pain (45-48%) and fever (15-17%). The other side effects were itching, swelling, fever, and shortness of breath. Around 17-18 % of respondents did not have any adverse reactions. There is no increase in the risk for younger children (years 1-3) compared with older children (years 4-6).
Conclusion: The children reported only mild adverse events such as injection pain, weakness, and fever. The CoronaVac has minimal side effects among elementary school children.
Analysis of Students' Mathematical Literacy Ability Through Mathematics Comics Based on Problem-Based Learning
Authors: Novferma Novferma , Romundza Febbry , Yenzi Indah Pristy 
Published: March 2024

Â Â Â Â Â Â Â Indonesian students' ability in mathematical literacy is classified as low; this is shown in several PISA survey results. What causes students' low mathematical literacy abilities in Indonesia is the need for more application of learning models and media that support students' mathematical literacy abilities. This research analyzes students' mathematical literacy skills using problem-based learning-based mathematical comics. This research is a type of qualitative research. The subjects of this research involved 25 class VIIIâ€”1 students at one of the schools in Batanghari, namely SMPN 21 Batanghari. The data collection technique in the study was a mathematical literacy ability test consisting of 5 essay questions. Data analysis in this research includes data reduction, data presentation, and concluding/verification. The research results showed that of the 25 students who took the mathematical literacy ability test, as many as 11 students, or 44%, had high levels of mathematical literacy skills. As many as 14 students, or 56% of students, had moderate mathematical literacy skills. No students had average levels of mathematical literacy skills. Low-level mathematics. Thus, it is concluded that students' mathematical literacy abilities after learning using problem-based learning-based mathematical comics fall into the category of medium-level mathematical literacy abilities as seen from the average score obtained on the students' mathematical literacy ability test, which is 79,72.
Ladder Distribution of LAIV Reassortment between Vero Adaption Attenuated Strain and Wide Type Highly Virulent Influenza Virus Strain
Authors: Liu Ze , Huang Jinhai , Hui Gao 
Published: March 2024

It described the “ladder distribution” of live attenuated influenza vaccine (LAIV) reassortment between Vero cells adaption attenuated strain and wide type-high virulent influenza virus strains by the reverse genetics approach. That gene constellation could save the immunogenicity (imm) of the parental strain and make new reassort virus strain attenuation (att) characteristics for further vaccine using, rapidly, not only seasonal vaccine but also pandemic flu vaccine.
Pengaruh Microbially Induced Calcite Precipitation (MICP) terhadap Perilaku Kuat Geser Tanah Terkontaminasi Batubara
Authors: Indriani Andi Marini , Utomo Gunaedy 
Published: March 2024

Microbially induced calcite precipitation (MICP) adalah teknik perbaikan tanah dengan menggunakan mikroorganisme yang mampu mengubah dan meningkatkan sifat mekanik dan fisik. Dalam penelitian ini, uji geser langsung dengan mengacu pada standard SNI 03-3420-1994 digunakan untuk mengetahui pengaruh pengendapan calcite terhadap perilaku kuat geser tanah terkontaminasi batubara. Bakteri Bacillus subtilis sebanyak 6% ditambahkan ke dalam tanah yang terkontaminasi 5%, 10% dan 15% batubara. Bakteri yang digunakan menggunakan kultur 3 hari dimana berada pada fase stasioner. Hasil penelitian menunjukkan bahwa terjadi peningkatan yang cukup baik terhadap nilai kohesi dan sudut geser dalam sebagai parameter kuat geser setelah masa pemeraman. Stabilisasi MICP pada tanah terkontaminasi 5% batubara meningkatkan kuat geser sebesar 3 kali lipat sedangkan pada tanah terkontaminasi 10% dan 15% batubara terjadi peningkatan kuat geser masing-masing sebesar 7 dan 15 kali lipat dibandingkan dengan tanah asli.
Evaluasi Runway Bandara Fatmawati dengan Menggunakan Software Comfaa
Authors: Sari Anggi Nidya , Amanah Tody , Pratama M. Ade Surya , Suryan Viktor , Amalia Kiki Rizky 
Published: March 2024

Pertumbuhan jumlah penduduk yang makin lama makin meningkat mengakibatkan penggunaan moda transportasi udara juga semakin meningkat. Penggunaan transportasi udara lebih disukai karena dapat menjangkau daerah yang cukup jauh dengan waktu tempuh yang lebih singkat. Pada sektor ekonomi juga diuntungkan dengan adanya transportasi udara, semua orang dapat membeli barang dari manapun mereka berada tanpa harus ketempat tersebut. Untuk meningkatkan pelayanan pada sektor penerbangan salah satu hal yang dilakukan yaitu menambah jumlah pesawat dengan kapasitas besar. Dengan bertambahnya jumlah pesawat mengakibatkan beban yang melalui runway bandara semakin besar. Untuk mengetahui apakah runway cukup kuat dalam menahan beban pesawat, evaluasi terhadap tebal perkerasan runway harus dilakukan. Pada penelitian ini evaluasi dilakukan dengan menggunakan software COMFAA. Data yang digunakan pada penelitian ini yaitu data pesawat yang melalui bandara Fatmawati, data CBR lapangan dan data eksisting perkerasan runway bandara Fatmawati. Data tebal perkerasan eksisting pada runway bandara untuk STA 0+100 sampai 1+800 yaitu 105 cm dan STA 1+800 sampai 2+250 yaitu 107,5cm, dengan nilai CBR lapangan 6% dan jenis pesawat B737-900ER serta A320 Twin opt. Hasil analisis menggunakan COMFAA menunjukkan nilai PCN > ACN dan nilai CDF < 1. Sehingga perkerasan runway bandara Fatmawati Soekarno masih layak dan aman digunakan untuk jenis pesawat Boeing 737-900 ER dan A320 Twin opt.