bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence and associated factors of occupational injuries in an industrial city in Ghana
Authors: Asiedu Michael Tetteh , Opoku Douglas Aninng , Ayisi-Boateng Nana Kwame , Osarfo Joseph , Sulemana Alhassan , Mohammed Aliyu , Amissah John , Ashilevi Jennifer , Mate-Kole Ayongo , Opoku Felix Agyemang , Yankson Isaac Kofi , Nakua Emmanuel Kweku 
Published: March 2024

Background
Workers are exposed to workplace hazards which increase their risk of occupational injury. Data on occupational injuries and associated factors are important for planning and informing national policy regarding workplace health and safety. This study sought to estimate the prevalence and factors associated with occupational injuries among workers in an industrial city in Ghana.

Methods
A community-based cross-sectional survey was conducted among 459 workers in the Tema industrial enclave in Ghana from 22nd December 2020 to 27th February 2021. Participants were recruited using a two-stage sampling technique. Eight communities were randomly selected from twenty-five communities in the first stage while households in each community were randomly selected in the second stage. Data on socio-demographic characteristics, occupational health and safety and occupational injuries were collected. Logistic regression was used to examine the relationship between occupational injuries and associated factors.

Results
The mean age of the workers was 33.9 (±6.8) years with a range of 21–53 while over 18.1% of them were working at the Port and Harbour. The prevalence of occupational injury among the workers in the preceding twelve months was 64.7%. The mechanism of injury was mainly the use of working tools (45.8%) and hot surfaces, substances or chemicals (14.1%). Being a casual staff (AOR: 2.26, 95%CI: 1.04–4.92), working at Port and Harbour (AOR: 3.77, 95%CI: 1.70–8.39), no health and safety training (AOR: 2.18, 95%CI: 1.08–4.39), dissatisfaction with health and safety measures (AOR: 4.31, 95%CI: 2.12–8.78) and tertiary education (AOR: 0.03, 95%CI: 0.01–0.10) were significantly associated with occupational injuries.

Conclusion
The prevalence of occupational injuries in this study was high. Promoting machine tools’ safety, health and safety training, and satisfaction with health and safety measures through rewarding workers who do not sustain injuries could be key to employees’ health and safety.
Legacies of the Portuguese Colonial Empire: Nationalism, Citizenship and Popular Culture, Elsa Peralta and Nuno Domingos (eds) (2023)
Authors: da Silva João Moreira 
Published: March 2024

Review of: Legacies of the Portuguese Colonial Empire: Nationalism, Citizenship and Popular Culture, Elsa Peralta and Nuno Domingos (eds) (2023)
London: Bloomsbury Publishing, 288 pp.,
ISBN 978-1-35028-977-2, h/bk, £85
Spontaneous Tumor Lysis Syndrome Secondary to Metastatic Pancreatic Adenocarcinoma
Authors: Gusdorf Jason , Markovitz Netana H. , Ricketts Cleveland , Ono Yuho , Lam Barbara D. , Berry Jonathan , Dockterman Jacob , Reddy Sheela 
Published: March 2024

ABSTRACT
Spontaneous tumor lysis syndrome (STLS) secondary to metastatic pancreatic adenocarcinoma is a rare clinical phenomenon. An 86-year-old woman with a history of pancreatic cysts presented to the emergency department with progressive fatigue, transaminitis, elevated lactate dehydrogenase, and acute kidney injury of unclear etiology. Abdominal imaging and celiac lymph node biopsy were consistent with metastatic pancreatic adenocarcinoma. Her clinical status deteriorated requiring intensive care unit transfer, and her laboratory results were found to be consistent with STLS. Despite treatment, she entered multisystem organ failure and died shortly after. This case adds to the literature of STLS in pancreatic adenocarcinomas.
Severe Elevated Bile Acids in Early Pregnancy
Authors: Fass Lucas , Sibbald Carrie , Bailey Erin , Zhang Wei , Lucey Michael 
Published: March 2024

ABSTRACT
Intrahepatic cholestasis of pregnancy (ICP) typically presents in the second half of pregnancy. Severe ICP is associated with increased risk of stillbirth. Little is known regarding elevated bile acids in the first trimester. We present a case of severely elevated bile acids in the first trimester, resistant to conservative management, in a patient with pre-existing cholestatic liver disease and aortic valve disease requiring anticoagulation. Therapeutic plasma exchange was used. In those with pre-existing cholestatic disease, early bile acid elevation is likely distinct from ICP, and conservative strategies may not be useful. In addition, therapeutic enoxaparin appears safe in therapeutic plasma exchange.
Lysosome-Related Genes and RNF19B as Prognostic Markers for Survival and Immunotherapy Efficacy in Hepatocellular Carcinoma
Authors: Li Jieying , Wang Hui , Lu Qian , Han Jiayi , Xu Haiyan , Sun Pingping , Xu Qiang , Huang Jianfei , Ji Juling 
Published: March 2024

INTRODUCTION:
Hepatocellular carcinoma (HCC) poses a considerable worldwide health concern due to its associated high risk of death. The heterogeneity of HCC poses challenges in developing practical risk stratification tools and identifying prognostic markers for personalized targeted treatments. Recently, lysosomes were shown to be crucial contributors to numerous cellular activities, including tumor initiation and immune response regulation. We aimed to construct a reliable prognostic signature based on lysosome-related genes and determine its association with the immune microenvironment.

METHODS:
We comprehensively analyzed lysosome-related genes in HCC to investigate their influence on patient survival and the tumor immune microenvironment. A prognostic signature comprising 14 genes associated with lysosomes was created to estimate the survival outcomes of individuals with HCC. In addition, we verified the prognostic importance of Ring Finger Protein 19B (RNF19B) in patients with HCC through multiplex immunohistochemistry analysis.

RESULTS:
Our constructed lysosome-related prediction model could significantly discriminate between HCC patients with good and poor survival outcomes (P < 0.05). We also found that elevated RNF19B expression was linked to unfavorable prognostic outcomes and showed a connection with specific clinicopathological characteristics. Moreover, it was observed that RNF19B could facilitate the transformation of macrophages into M2-polarized macrophages and showed a significant positive correlation with PD-1 and CTLA-4.

DISCUSSION:
In summary, our study proposes that the expression of lysosome-related genes is associated with the immune microenvironment, serving as a predictor for HCC patient survival. Meanwhile, RNF19B was identified as a novel prognostic marker for predicting overall survival and immunotherapy effects in patients with HCC.
Adeno‐associated virus‐based approach for genetic modification of cardiac fibroblasts in adult rat hearts
Authors: Nieto Bridget , Cypress Michael W. , Jhun Bong Sook , O‐Uchi Jin 
Published: March 2024

AbstractCardiac fibroblasts (CFs) are an attractive target for reducing pathological cardiac remodeling, and understanding the underlying mechanisms of these processes is the key to develop successful therapies for treating the pressure‐overloaded heart. CF‐specific knockout (KO) mouse lines with a Cre recombinase under the control of human TCF21 (hTCF21) promoter and/or an adeno‐associated virus serotype 9 (AAV9)‐hTCF21 system provide a powerful tool for understanding CF biology in vivo. Although a variety of rat disease models are vital for the research of cardiac fibrosis similar to mouse models, there are few rat models that employ cardiac cell‐specific conditional gene modification, which has hindered the development and translational relevance of cardiac disease models. In addition, to date, there are no reports of gene manipulation specifically in rat CFs in vivo. Here, we report a simplified CF‐specific rat transgenic model using an AAV9‐hTCF21 system that achieved a CF‐specific expression of transgene in adult rat hearts. Moreover, we successfully applied this approach to specifically manipulate mitochondrial morphology in quiescent CFs. In summary, this model will allow us to develop fast and simple rat CF‐specific transgenic models for studying cardiovascular diseases in vivo.
KAT2A changes the function of endometrial stromal cells via regulating the succinylation of ENO1
Authors: Zeng Kangkang , Yin Hao 
Published: March 2024

Abstract
Endometriosis is increasingly affecting women worldwide and research is focusing on identifying key targets in its pathogenesis. Changes in succinylation genes regulate the function of this protein and further influence the development of the disease. However, the role of succinylation genes in endometriosis is not clear from current studies. The expression of succinylation genes was determined in ectopic endometrium (EC) and ectopic patients with uterine fibroids (EN) by real-time quantitative PCR (qRT-PCR) and Western blot. Cell Counting Kit-8, transwell assays, and flow cytometry were used to assess endometrial stromal cells (ESCs) proliferation, apoptosis, migration, and invasion. KAT2A and ENO1 association was detected by qRT-PCR, immunofluorescence, and CoIP. We found that gene and protein levels of KAT2A were significantly increased in the EC group compared to EN group tissues. KAT2A silencing inhibited cell proliferation, migration, and invasion and promoted apoptosis. Western blot results showed that the expression of ENO1 and its succinylation was significantly upregulated in ECSc after KAT2A overexpression. CoIP results showed that KAT2A is positively bound to ENO1. Immunofluorescence also showed co-localized expression of KAT2A with ENO1. Furthermore, ENO1 overexpression reversed the effects of KAT2A silencing on the malignant behavior of ESCs. In summary, we found that succinylation of ENO1 mediated by KAT2A played a role in promoting the progression of endometriosis.
Exploring antioxidant strategies in the pathogenesis of ALS
Authors: Pinilla-González Víctor , Montecinos-Barrientos Benjamin , Martin-Kommer Clemente , Chichiarelli Silvia , Saso Luciano , Rodrigo Ramón 
Published: March 2024

Abstract
The central nervous system is essential for maintaining homeostasis and controlling the body’s physiological functions. However, its biochemical characteristics make it highly vulnerable to oxidative damage, which is a common factor in neurodegenerative diseases like amyotrophic lateral sclerosis (ALS). ALS is a leading cause of motor neuron disease, characterized by a rapidly progressing and incurable condition. ALS often results in death from respiratory failure within 3–5 years from the onset of the first symptoms, underscoring the urgent need to address this medical challenge. The aim of this study is to present available data supporting the role of oxidative stress in the mechanisms underlying ALS and to discuss potential antioxidant therapies currently in development. These therapies aim to improve the quality of life and life expectancy for patients affected by this devastating disease.
The counting principle makes number words unique
Authors: Ariel Mira , Levshina Natalia 
Published: March 2024

Abstract
Following Ariel (2021. Why it’s hard to construct ad hoc number concepts. In Caterina Mauri, Ilaria Fiorentini, & Eugenio Goria (eds.), Building categories in interaction: Linguistic resources at work, 439–462. Amsterdam: John Benjamins), we argue that number words manifest distinct distributional patterns from open-class lexical items. When modified, open-class words typically take selectors (as in kinda table), which select a subset of their potential denotations (e.g., “nonprototypical table”). They are typically not modified by loosening operators (e.g., approximately), since even if bare, typical lexemes can broaden their interpretation (e.g., table referring to a rock used as a table). Number words, on the other hand, have a single, precise meaning and denotation and cannot take a selector, which would need to select a subset of their (single) denotation (??kinda seven). However, they are often overtly broadened (approximately seven), creating a range of values around N. First, we extend Ariel’s empirical examination to the larger COCA and to Hebrew (HeTenTen). Second, we propose that open-class and number words belong to sparse versus dense lexical domains, respectively, because the former exhibit prototypicality effects, but the latter do not. Third, we further support the contrast between sparse and dense domains by reference to: synchronic word2vec models of sparse and dense lexemes, which testify to their differential distributions, numeral use in noncounting communities, and different renewal rates for the two lexical types.
Emotionally (in)hospitable spaces: reflecting on language teacher–teacher educator collaboration as a source of emotion labor and emotional capital
Authors: Cinaglia Carlo , Montgomery D. Philip , Coss Matthew D. 
Published: March 2024

Abstract
While various aspects of language teachers’ emotional experiences have been gaining attention, including emotion labor and emotional capital, less attention has been placed on the emotional experiences of teacher educators supporting language teachers in emotionally challenging situations. Following calls to examine language teachers’ emotional experiences ecologically and as socially and institutionally shaped, we engaged in collaborative autoethnography to explore how language teacher and teacher educator emotion labor reflects answerability to multiple commitments in the face of external feeling rules. Our findings highlight how language teacher–teacher educator collaboration can mitigate as well as reproduce emotion labor. This study contributes to research on language teacher emotion labor by focusing on the role of the teacher educator in supporting language teacher emotional capital and highlighting the complexity underlying emotion labor and emotional capital as multi-directional. Furthermore, the study illustrates how collaborative autoethnography can generate reflexivity and emotional capital for language teacher educators.
Investigation of 16 × 10 Gbps mode division multiplexed enabled integrated NGPON–FSO architecture under wired-wireless link losses
Authors: Kumari Meet 
Published: March 2024

Abstract
To enhance the transmission capacity for energy consumption and low cost system, mode division multiplexing (MDM) using mode 0 and mode 1 is proposed and investigated. A pair of eight downlink and uplink wavelengths is transmitted by using each MDM mode in an integrated bidirectional next generation passive optical network and free space optics (NGPON–FSO) system at 10 Gbps per channel transmission rate under the impact of FSO–fiber links impairments. Simulation results indicate that received power of −21.2 dBm with 0.2 dB power penalty can be obtained over 1 km FSO and 100 m multimode fiber under unfavourable turbulent effects. The system provides extended FSO link range, and fiber range of 150 km and 600 m respectively at threshold limit of 10−3. Besides, the mathematical analysis depicts the receiver sensitivity and splitter power budget of 42 dBm and 18 dB, respectively, for the proposed system. The system offers finest performance than other pre-existing systems.
AÇÃO EXTENSIONISTA: UMA OPORTUNIDADE DA UNIVERSIDADE COMILITAR AO LADO DE PESSOAS EM VULNERABILIDADE DE GÊNERO
Authors: Medianeira Bolzan Larissa 
Published: March 2024

O objetivo deste artigo foi compreender o papel de uma universidade pública extensionista na cocriação de Inovação Social (IS). Considerando que as ações extensionistas sejam orientadas pelo ato Dusseliano de colocar-se “efetiva e praticamente ‘junto’ ao Outro no que tange aos vazios institucionais acerca de problemas socioambientais. Para tanto, o Living Lab (LL) “Mais Juntas” serviu como objeto de análise. O método para desenvolvimento deste trabalho foi a pesquisa-ação. De modo geral, esta pesquisa evidenciou que em ações de extensão a universidade é capaz de orquestrar o processo de cocriação de inovações sociais colocando-se “efetiva e praticamente ‘junto’ ao Outro” (DUSSEL, 2001), uma vez que no Living Lab Mais Juntas, todas ações foram orquestradas pelo projeto unificado com ênfase em extensão “Mais Juntas” da UFPel.É válido destacar ainda que a utilização do método de cocriação Design Sprint, validado neste artigo para utilização na cocriação de inovações sociais, possibilitou a mobilidade de conhecimento e a manutenção da estabilidade da rede, assim como uma comunicação horizontal e a construção do capital relacional entre os atores.
PROAMAMENTA: PROMOVENDO A AMAMENTAÇÃO E A SAÚDE MENTAL NA MATERNIDADE DURANTE A PANDEMIA DA COVID-19
Authors: Louise Gonçalves Caires Tharine , Beatriz Laureta dos Santos Oliveira Ana , Aleluia Castilho Jordana , Ketelly de Freitas Pires Karen 
Published: March 2024

O aleitamento materno é recomendado como principal meio de alimentação e prevenção de doenças para o bebê. A amamentação inicia-se no puerpério, que é considerado um período de vulnerabilidade em relação à saúde mental, modificações fisiológicas, hormonais e sociais que ocorrem nesse período na mulher. Portanto, a rede de apoio familiar e profissional é uma importante ferramenta para garantir o acolhimento e o sucesso da amamentação, considerando que a insegurança, estresse e ansiedade são característicos do puerpério, e podem favorecer o desmame precoce. O projeto de extensão interdisciplinar ProAmamenta, composto pelos cursos de Enfermagem e Psicologia, visa promover educação em saúde e acolhimento às puérperas, levando conhecimento, em relação aos benefícios, vantagens e importância da amamentação.Devido à pandemia do vírus COVID-19, o projeto vem atuando de forma remota desde março de 2020. A utilização das plataformas digitais, possibilitou um maior alcance e interação com a comunidade, assim como trouxe a possibilidade de ampliar as discussões sobre a temática por meio da realização de palestras transmitidas ao vivo pelo instagram. Atualmente, o projeto está construindo o seu retorno presencial com o intuito de continuar prestando orientação para as puérperas e seus familiares. O projeto tem contribuído de forma significativa no processo de amamentação de muitas mulheres, principalmente na orientação psicológica e sobre a importância que esta prática possui para todos os envolvidos: mulher, criança, família e comunidade.
Implementação do Sistema de Gestão da Qualidade em Laboratório de Genética Forense na Amazônia: experiências e desafios
Authors: Costa Gilcelene , Da costa francez Pablo abdon , De Oliveira Godinho Neide Maria 
Published: March 2024

Este artigo aborda a implementação do sistema de gestão da qualidade (SGQ), no período de 2018 a 2022, ocorrido no Laboratório de Genética Forense da Polícia Cientifica do Amapá (LGF/PCA). Desde 2010, o LGF/PCA participa do compartilhamento de perfis genéticos com outros laboratórios de DNA forense no Brasil, através do banco de dados de perfis genéticos criminal e de identificação, utilizando o software CODIS. Porém, a Rede Integrada de Perfis Genéticos (RIBPG) instituiu resoluções especificas, sendo Resolução nº 12-CG/RIBPG, de 1 de agosto de 2019, a que estabelece os critérios mínimos para que um LGF no Brasil possa compartilhar os perfis genéticos a partir do Banco Nacional de Perfis Genético (BNPG). E utilizando uma metodologia descritiva e exploratória com abordagem qualitativa através de pesquisa bibliográfica, documentais e observações diretas, os autores descrevem como foi o desenvolvimento e os resultados observados antes e após a implementação do SGQ tendo como parâmetro de análise as auditorias externas e interna pelas quais o LGF/PCA foi submetido, destacando-se as experiências e desafios enfrentados, com o objetivo de ajudar a fomentar o conhecimento para outros laboratórios que estão iniciando a jornada da qualidade.
Analisis Kapilaritas Air pada Kain
Authors: Ardiani Septia , Rahmayanti Handika Dany , Akmalia Nurul 
Published: March 2024

Kajian mengenai kapilaritas serapan air pada kain merupakan hal yang sifatnya sederhana namun penting dilakukan untuk memberikan informasi kepada masyarakat mengenai karakteristik kain serta demi berkembangnya penelitian mengenai daya serap berbagai jenis kain. Pada penelitian ini digunakan enam jenis kain yaitu kain satin, kain flanel, kain katun, kain sifon, kain crepe, dan kain jersey. Pada pengujian kapilaritas serapan air pada kain, besaran fisika yang dianalisis adalah ketinggian dan kelajuan serapan air. Berdasarkan hasil uji kapilaritas pada kain didapatkan bahwa ketinggian serapan air sebanding dengan kelajuan serapan air. Kelajuan serapan air menunjukkan kapilaritas serapan. Nilai ketinggian serapan air tertinggi adalah kain flanel yakni berkisar 5,1Â±0,2 cm sedangkan ketinggian serapan air terendah adalah kain satin yakni 2,4Â±0,2 cm. Kain katun, sifon, dan jersey memiliki ketinggian serapan air yang hampir sama. Kapilaritas tertinggi adalah kain flanel sebesar 0,086 cm/s sedangkan kapilaritas terendah adalah kain satin sebesar 0,040 cm/s. Kain Â katun, sifon, dan jersey memiliki kapilaritas serapan air yang sama yaitu 0.070 cm/s.
Pemahaman tentang Gizi dan Perilaku Kesehatan Ibu pada Fenomena Balita Stunting (Studi Fenomenologi Masyarakat Kelurahan Candirejo Kecamatan Ungaran Barat)
Authors: Al Hakim Muhammad Nu’man , Husain Fadly 
Published: March 2024

Kelurahan Candirejo merupakan kelurahan binaan Universitas Ngudi Waluyo, dengan kategori masyarakat kelas menengah dan lokasinya yang strategis karena dekat dengan pusat kota Kabupaten Semarang, namun memiliki kasus balita stunting tertinggi se-Kecamatan Ungaran Barat selama tiga tahun berturut-turut pada tahun 2019, 2020, dan 2021. Penelitian ini bertujuan 1) mengetahui persepsi dan pengetahuan dari masyarakat dan penyedia layanan kesehatan tentang stunting dan kesehatan anak, 2) mengetahui pemahaman sosio-kultural masyarakat Kelurahan Candirejo tentang makanan dan gizi, 3) mengetahui perilaku kesehatan ibu saat hamil hingga setelah melahirkan bagi ibu yang memiliki balita stunting.
Penelitian ini merupakan penelitian kualitatif dengan metode pengumpalan datanya adalah observasi, wawancara, dan dokumentasi. Validitas data untuk mencapai derajat keabsahan hasil penelitian menggunakan triangulasi. Teknik analisis data yang digunakan adalah model Creswell, yaitu 1) data lapangan hasil wawancara, 2) pengetikan data: teks, 3) membaca keseluruhan teks, 4) koding dan kualifikasi, 5) Deskripsi, pola, dan tema. Hasil Penelitian dianalisis menggunakan konsep makanan dan gizi Foster dan Anderson serta teori perilaku kesehatan Lawrence Green.
Hasil penelitian menunjukan bahwa sebagian masyarakat Kelurahan Candirejo mempersepsikan stunting istilah cebol atau pendek. Istilah cebol di Kelurahan Candirejo menjadi kata-kata bermakna ejekan, hal ini menjadi salah satu alasan sebagian orang tua yang memiliki anak stunting selalu mencari pembenaran bahwa anaknya tidak mengalami stunting dan anaknya akan tinggi suatu saat nanti tepatnya ketika anaknya sudah SMP. Selain mencari pembenaran, sebagian masyarakat Kelurahan Candirejo, juga tidak suka di atur dalam pemilihan makanan dan lebih memilih makanan berdasarkan kebiasaan makanan sehari-hari dan cita rasa yang menurutnya enak, terlepas makanan itu bergizi atau tidak. Ada pula budaya pantang makan yang dipercaya sebagian masyarakat yaitu saat kondisi hamil dan menyusui, contoh salah satunya ikan lele yang menjadi pantang dimakan saat hamil dan makanan pantang saat menyusui adalah udang.