bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Prospective Analysis of Low‐Grade Gastric MALT Lymphoma after Helicobacter pylori Eradication
Authors: Hong Seong Soo , Jung Hwoon‐Yong , Choi Kee Don , Song Ho June , Lee Gin Hyug , Oh Tae Hoon , Jo Ji‐Yun , Kim Kyu‐Jong , Byeon Jeong‐Sik , Myung Seung‐Jae , Yang Suk‐Kyun , Hong Weon‐Seon , Kim Jin‐Ho , Min Young Il 
Published: November 2006

AbstractBackground:  Primary gastric low‐grade B‐cell lymphoma of mucosa‐associated lymphoid tissue (MALT lymphoma) is known to be successfully treated with anti‐Helicobacter pylori (H. pylori) therapy alone. However, there are few reports on long‐term results after eradication therapy. The aims of this study were to analyze the rate and the interval to reach complete remission (CR), and to assess the rate and the factors affecting recurrence of MALT lymphoma.Materials and Methods:  Between 1996 and 2003, a total of 90 H. pylori‐infected patients with low‐grade MALT lymphoma were included in this study. For initial staging, endoscopic ultrasonography, chest–abdomen–pelvis CT scans, and bone marrow examination were taken. All patients were made to take anti‐H. pylori therapy for 14 days. Tumoral response was assessed by endoscopy every 3 months till CR and every 6 months after achieving CR.Results:  Among 90 treated patients, 85 (94.4%) reached CR. The median interval to CR was 3 months (range, 1–24). Seventy‐nine (92.9%) patients were in CR at 12 months. Median follow‐up period after CR was 45 months (range 15–109). Among 77 patients who were followed‐up after CR, 8 (10.4%) patients were proved with recurrence of MALT lymphoma. Cumulative recurrence rate was 2.7, 11.5, and 12.2% at 1, 2, and 3 years. The presence of H. pylori was only a significant risk factor affecting recurrence.Conclusions:  The status of H. pylori is the most important risk factor affecting recurrence. Therefore, adequate eradication regimen and accurate regular evaluation for H. pylori status are needed during follow up of primary gastric low‐grade B‐cell MALT lymphoma.
Petrogenesis of lawsonite and epidote eclogite and blueschist, Sivrihisar Massif, Turkey
Authors: DAVIS P. B. , WHITNEY D. L. 
Published: November 2006

AbstractThe Sivrihisar Massif, Turkey, is comprised of blueschist and eclogite facies metasedimentary and metabasaltic rocks. Abundant metre‐ to centimetre‐scale eclogite pods occur in blueschist facies metabasalt, marble and quartz‐rich rocks. Sivrihisar eclogite contains omphacite + garnet + phengite + rutile ± glaucophane ± quartz + lawsonite and/or epidote. Blueschists contain sodic amphibole + garnet + phengite + lawsonite and/or epidote ± omphacite ± quartz. Sivrihisar eclogite and blueschist have similar bulk composition, equivalent to NMORB, but record different P–T conditions: ∼26 kbar, 500 °C (lawsonite eclogite); 18 kbar, 600 °C (epidote eclogite); 12 kbar, 380 °C (lawsonite blueschist); and 15–16 kbar, 480–500 °C (lawsonite‐epidote blueschist). Pressures for the Sivrihisar lawsonite eclogite are among the highest reported for this rock type, which is rarely exposed at the Earth's surface. The distribution and textures of lawsonite ± epidote define P–T conditions and paths. For example, in some lawsonite‐bearing rocks, epidote inclusions in garnet and partial replacement of matrix epidote by lawsonite suggest an anticlockwise P–T path. Other rocks contain no epidote as inclusions or as a matrix phase, and were metamorphosed entirely within the lawsonite stability field. Results of the P–T study and mapping of the distribution of blueschists and eclogites in the massif suggest that rocks recording different maximum P–T conditions were tectonically juxtaposed as kilometre‐scale slices and associated high‐P pods, although all shared the same exhumation path from ∼9–11 kbar, 300–400 °C. Within the tectonic slices, alternating millimetre–centimetre‐scale layers of eclogite and blueschist formed together at the same P–T conditions but represent different extents of prograde reaction controlled by strain partitioning or local variations in fO2 or other chemical factors.
A Novel Pacing Maneuver to Localize Focal Atrial Tachycardia
Authors: MOHAMED UWAIS , SKANES ALLAN C. , GULA LORNE J. , LEONG‐SIT PETER , KRAHN ANDREW D. , YEE RAYMOND , SUBBIAH RAJESH , KLEIN GEORGE J. 
Published: November 2006

Background: Although focal atrial tachycardias cannot be entrained, we hypothesized that atrial overdrive pacing (AOP) can be an effective adjunct to localize the focus of these tachycardias at the site where the post‐pacing interval (PPI) is closest to the tachycardia cycle length (TCL). Methods: Overdrive pacing was performed in nine patients during atrial tachycardia, and in a comparison group of 15 patients during sinus rhythm. Pacing at a rate slightly faster than atrial tachycardia in group 1 and sinus rhythm in group 2 was performed from five standardized sites in the right atrium and coronary sinus. The difference between the PPI and tachycardia or sinus cycle length (SCL) was recorded at each site. The tachycardia focus was then located and ablated in group 1, and the atrial site with earliest activation was mapped in group 2. Results: In both groups the PPI‐TCL at the five pacing sites reflected the distance from the AT focus or sinus node. In group 1, PPI‐TCL at the successful ablation site was 11 ± 8 msec. In group 2, PPI‐SCL at the site of earliest atrial activation was 131 ± 37 msec (P < 0.001 for comparison). In groups 1 and 2, calculated values at the five pacing sites were proportional to the distance from the AT focus or sinus node, respectively. Conclusions: The PPI‐TCL after‐AOP of focal atrial tachycardia has a direct relationship to proximity of the pacing site to the focus, and may be clinically useful in finding a successful ablation site.
Response of retinal arteriole diameter to increased blood pressure during acute hyperglycaemia
Authors: Jeppesen Peter , Knudsen Søren T. , Poulsen Per L. , Mogensen Carl E. , Schmitz Ole , Bek Toke 
Published: November 2006

Abstract.Purpose:  To study retinal response in terms of arteriole diameter and retinal thickness secondary to an increase in arterial blood pressure during acute hyperglycaemia.Methods:  In a randomized, double‐blinded, cross‐over study, nine healthy persons were subjected to clamping of blood glucose to either 5 mmol/l or 15 mmol/l using somatostatin to control endogenous insulin secretion. The response of retinal arterioles in terms of diameter as determined with the retinal vessel analyser (RVA) and retinal thickness as assessed by optical coherence tomography (OCT) were measured after an increase in arterial blood pressure induced by isometric exercise. Arterial feeding pressure in the eye was assessed from the ophthalmic artery pressure and pulse amplitude measured by ophthalmodynamometry.Results:  Isometric exercise induced a significant increase in mean arterial blood pressure and a significant contraction of the retinal arterioles. An acute increase in blood glucose from 5 mmol/l to 15 mmol/l did not affect either the diameter of retinal vessels or retinal thickness.Conclusions:  Acute hyperglycaemia per se does not change isometric exercise‐induced retinal arteriolar contraction. Metabolic factors other than blood glucose are suspected to be involved in the impairment of retinal autoregulation as seen in hyperglycaemia induced by oral glucose intake.
Structural Investigations of the Membrane-Embedded Rotor Ring of the F-ATPase from
Clostridium paradoxum
Authors: Meier Thomas , Ferguson Scott A. , Cook Gregory M. , Dimroth Peter , Vonck Janet 
Published: November 2006

ABSTRACT

The Na
+
-translocating F-ATPase of the thermoalkaliphilic bacterium
Clostridium paradoxum
harbors an oligomeric ring of c subunits that resists dissociation by sodium dodecyl sulfate. The c ring has been isolated and crystallized in two dimensions. From electron microscopy of these c-ring crystals, a projection map was calculated to 7 Å resolution. In the projection map, each c ring consists of two concentric, slightly staggered, packed rings, each composed of 11 densities representing the α-helices. On the basis of these results, it was determined that the F-ATPase from
C. paradoxum
contains an undecameric c ring.
Heparanase, Hyaluronan, and CD44 in Cancers: A Breast Carcinoma Perspective
Authors: Götte Martin , Yip George W. 
Published: November 2006

AbstractGlycosaminoglycans are major constituents of the cancer cell surface and the tumor stroma. The heparan sulfate degrading enzyme heparanase, hyaluronan, and its receptor CD44 are up-regulated in breast cancer, generating a microenvironment that promotes tumor progression and metastasis. Recent experimental and clinical evidence shows that heparanase, hyaluronan, and CD44 regulate cancer cell proliferation, migration, and invasion, as well as tumor-associated angiogenesis and are correlated with patient survival. These findings suggest that they may be used as prognostic factors and targets for breast cancer treatment. (Cancer Res 2006; 66(21): 10233-7)
Membrane Ganglioside Enrichment Lowers the Threshold for Vascular Endothelial Cell Angiogenic Signaling
Authors: Liu Yihui , McCarthy James , Ladisch Stephan 
Published: November 2006

Abstract
Malignant tumor progression depends on angiogenesis, requiring vascular endothelial cell migration, and proliferation, triggered by tumor-derived vascular endothelial cell growth factor (VEGF). We show that gangliosides, which are actively shed by tumor cells and bind to normal cells in the tumor microenvironment, have the potential to sensitize vascular endothelial cells to respond to subthreshold levels of VEGF: Ganglioside enrichment of human umbilical vein vascular endothelial cells (HUVEC) caused very low, normally barely stimulatory, VEGF concentrations to trigger robust VEGF receptor dimerization and autophosphorylation, as well as activation of downstream signaling pathways, and cell proliferation and migration. Thus, by dramatically lowering the threshold for growth factor activation of contiguous normal stromal cells, shed tumor gangliosides may promote tumor progression by causing these normal cells to become increasingly autonomous from growth factor requirements by a process that we term tumor-induced progression of the microenvironment. (Cancer Res 2006; 66(21): 10408-14)
Disulfiram, a Clinically Used Anti-Alcoholism Drug and Copper-Binding Agent, Induces Apoptotic Cell Death in Breast Cancer Cultures and Xenografts via Inhibition of the Proteasome Activity
Authors: Chen Di , Cui Qiuzhi Cindy , Yang Huanjie , Dou Q. Ping 
Published: November 2006

Abstract
Disulfiram (DSF), a member of the dithiocarbamate family capable of binding copper and an inhibitor of aldehyde dehydrogenase, is currently being used clinically for the treatment of alcoholism. Recent studies have suggested that DSF may have antitumor and chemosensitizing activities, although the detailed molecular mechanisms remain unclear. Copper has been shown to be essential for tumor angiogenesis processes. Consistently, high serum and tissue levels of copper have been found in many types of human cancers, including breast, prostate, and brain, supporting the idea that copper could be used as a potential tumor-specific target. Here we report that the DSF-copper complex potently inhibits the proteasomal activity in cultured breast cancer MDA-MB-231 and MCF10DCIS.com cells, but not normal, immortalized MCF-10A cells, before induction of apoptotic cancer cell death. Furthermore, MDA-MB-231 cells that contain copper at concentrations similar to those found in patients, when treated with just DSF, undergo proteasome inhibition and apoptosis. In addition, when administered to mice bearing MDA-MB-231 tumor xenografts, DSF significantly inhibited the tumor growth (by 74%), associated with in vivo proteasome inhibition (as measured by decreased levels of tumor tissue proteasome activity and accumulation of ubiquitinated proteins and natural proteasome substrates p27 and Bax) and apoptosis induction (as shown by caspase activation and apoptotic nuclei formation). Our study shows that inhibition of the proteasomal activity can be achieved by targeting tumor cellular copper with the nontoxic compound DSF, resulting in selective apoptosis induction within tumor cells. (Cancer Res 2006; 66(21): 10425-33)
PRKAR1A Inactivation Leads to Increased Proliferation and Decreased Apoptosis in Human B Lymphocytes
Authors: Robinson-White Audrey J. , Leitner Wolfgang W. , Aleem Eiman , Kaldis Philipp , Bossis Ioannis , Stratakis Constantine A. 
Published: November 2006

Abstract
The multiple neoplasia syndrome Carney complex (CNC) is caused by heterozygote mutations in the gene, which codes for the RIα regulatory subunit (PRKAR1A) of protein kinase A. Inactivation of PRKAR1A and the additional loss of the normal allele lead to tumors in CNC patients and increased cyclic AMP signaling in their cells, but the oncogenetic mechanisms in affected tissues remain unknown. Previous studies suggested that PRKAR1A down-regulation may lead to increased mitogen-activated protein kinase (MAPK) signaling. Here, we show that, in lymphocytes with PRKAR1A-inactivating mutations, there is increased extracellular signal-regulated kinase (ERK) 1/2 and B-raf phosphorylation and MAPK/ERK kinase 1/2 and c-Myc activation, whereas c-Raf-1 is inhibited. These changes are accompanied by increased cell cycle rates and decreased apoptosis that result in an overall net gain in proliferation and survival. In conclusion, inactivation of PRKAR1A leads to widespread changes in molecular pathways that control cell cycle and apoptosis. This is the first study to show that human cells with partially inactivated RIα levels have increased proliferation and survival, suggesting that loss of the normal allele in these cells is not necessary for these changes to occur. (Cancer Res 2006; 66(21): 10603-12)
Defining international social work
Authors: Xu Qingwen 
Published: November 2006

English Interest in international social work has been growing, as social workers are increasingly confronting problems stemming from international forces. However, there is no agreement on defining this particular field of practice. This agency-oriented study presents the aspect of today's international social work -- the global context's penetration of the local context. French L'intérêt envers le travail social international ne cesse de croître, les travailleurs sociaux étant de plus en plus souvent interpellés par les problèmes que le personnel international essaie d'endiguer. Toutefois, il n'existe pas d'entente régissant ce champ d'exercice particulier. Cette recherche axée sur l'agence présente la situation actuelle du travail social international -- en mettant l'accent sur la pénétration du contexte mondial dans le contexte local. Spanish El interés por el trabajo social internacional crece a medida que los trabajadores sociales confrontan más problemas provocados por fuerzas internacionales. A pesar de ello, no existe un consenso sobre la definición de este campo particular de práctica. Este estudio, basado en la experiencia de una agencia, presenta el aspecto del trabajo social internacional de hoy la penetración del contexto global en el local.
The effects of an intervention group with the support of non-pharmacological Chinese medicine on older Chinese adults with insomnia
Authors: Chan Kai-fong , Ng Petrus , Ng Ka-ying 
Published: November 2006

English This article reports a pilot study on an intervention group which integrated behavioral treatment and non-pharmacological Chinese medicine to reduce the problem of insomnia for older Chinese adults. Findings showed that the six-session group intervention was effective. The highlight of each session was presented and implications for social work practice discussed. French Cet article présente les résultats d'un projet pilote en intervention de groupe, mené pour répondre aux problèmes d'insomnie de la population âgée de Hong Kong. Ce projet a fait appel à des traitements comportementaux et à la pharmacopée traditionnelle chinoise. Les résultats indiquent que les interventions de groupe ont été concluantes. On aborde également les implications pour le travail social en Chine et ailleurs. Spanish Se informa sobre un estudio piloto de una intervención de grupo para tratar los problemas de insomnio entre personas mayores en Hong Kong. Esta intervención integra los tratamientos de conducta y medicina china no farmacológica. Los resultados sugieren que la intervención de grupo fue efectiva. Se exponen las implicaciones para el trabajo social en China y en otros lugares.
A suggested push model for interpreting the dilemmas of institutional care, community care and family care of mental-health consumers
Authors: Yip Kam-shing 
Published: November 2006

English This article suggests a push model for analyzing dilemmas between institutional care, community care and family care of mental-health consumers. In the USA community care is overloaded by inappropriate de-institutionalization. In Hong Kong, family caregivers are severely burdened by poor community care and highly institutionalized services. French Cet article suggéré un modèle dit de poussée dans l'analyse des dilemmas qui surgissent entre les soins d'ordre institutionnel, communautaire et familiaux auprès des clientèles en santé mentale. Aux États-Unis, les organismes communautaires sont surchargés dus à des pratiques de désinstitutionnalisation inappropriées. Á Hong Kong, les soignants familiaux se sentient écrasés par un lourd fardeau en raison de la pauvreté des soins. Spanish Se sugiere un modelo (`push model') para analizar los dilemmas entre el cuidado institucional, el cuidado familiar, y el cuidado comunitario de pacientes de salud mental. En los EE.UU el cuidado comunitario está sobrecargadas debido a los escasos cuidados comunitarios y a una alta institucionalización.
Welfare lobby groups responding to globalization
Authors: Mendes Philip 
Published: November 2006

English Theories of globalization suggest that national lobby groups continue to exert influence on social policy agendas and outcomes. Yet little has been written about the impact of globalization on the political and ideological context within which pro-welfare state advocacy groups operate. This article explores the response of an Australian welfare lobby group to the challenges posed by globalization. French Les théories de la mondialisation soutiennent que les groupes de pression nationaux continuent d'exercer leur influence sur les projets et les définitions des politiques sociales. Pourtant, on recense peu d'écrits sur la façon dont la mondialisation influence le contexte politique et idéologique dans lequel travaillent les groupes de pression en faveur de l'aide sociale. Cette étude explore la position d'un groupe de pression australien en égard aux défis de la mondialisation. Spanish Las teorías de la globalización sugieren que los grupos nacionales de presión continúan ejerciendo influencia en las agendas y resultados de la política social. Se ha escrito poco sobre el impacto de la globalización en el contexto política social. Se ha escrito poco sobre el impacto de la globalización en el contexto político e ideológico, en el cual operan los grupos que abogan en pro del bienestar. Este artículo explora las respuestas de un grupo australiano de presión por el bienestar, frente a los desafióos que ofrece la globalización.
When children have problems
Authors: Shor Ron 
Published: November 2006

English In this comparative study of parents' help-seeking approaches, immigrants from the former Soviet Union indicated a lower level of willingness to help and different rationales for seeking help from both formal and informal sources than did Israeli-born parents. French Cette étude comparée sure les stratégies de demande d'aide pour les enfants en difficulté démontre que les immigrants des anciennes républiques de l'Union Soviétique sont moins enclins à rechercher de l'aide que les parents de nationalité israélienne et que leurs motifs diffèrent auprès des sources formelles ou informelles d'aide. Spanish En un estudio comparativo sobre los padres que buscan ayuda cuando sus hijos tienen problemas, los inmigrantes de la antigua Unión Soviética indicaron menor nivel de buena voluntad para ayudar -- y diferente racionalidad en la búsqueda de fuentes formales e informales -- que los padres nacidos en Israel.
A Single Injection of d-Amphetamine Facilitates Improvements in Motor Training Following a Focal Cortical Infarct in Squirrel Monkeys
Authors: Barbay Scott , Zoubina Elena V. , Dancause Numa , Frost Shawn B. , Eisner-Janowicz Ines , Stowe Ann M. , Plautz Erik J. , Nudo Randolph J. 
Published: November 2006

Background. There is growing interest in the use of d-amphetamine (d-AMPH) as a pharmacological treatment to supplement rehabilitative therapy following stroke. Based on the success of earlier animal models, several clinical studies have demonstrated beneficial effects of applying physical rehabilitation while stroke patients are under the influence of d-AMPH. To begin to understand the neural mechanisms underlying this promising adjuvant therapy, the authors examined the effects of a single pairing of d-AMPH and rehabilitative training on motor performance after cortical infarct in squirrel monkeys. Methods. Microelectrode stimulation techniques were used to delineate hand movement areas in the primary motor cortex prior to delivering a unilateral infarct to the complete hand representation. Postinfarct recovery was assessed for 3 groups of monkeys: d-AMPH + training, saline + training, and spontaneous recovery (SR). Postinfarct training groups received 14 consecutive days of motor skill training on a reach and retrieval task. A single injection of d-AMPH (0.25 mg/kg) or saline was given only on the 1st day of training (postinfarct day 10). Monkeys in the SR group had only minimal exposure to the training task once per week to monitor recovery. Results. The results show that a single coupling of d-AMPH + training initiated 10 days after cortical infarct facilitated the rate of recovery and improved performance (68% improvement from 1st day of training) beyond the level achieved by the monkeys in the saline + training group (27% improved from 1st day of training). Conclusions. D-AMPH is a potent modulator of behavioral recovery following an ischemic infarct in nonhuman primates.