bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: First Example of the Carbon‐Ferrier Rearrangement of Glycals with Isocyanides: A Novel Synthesis of C‐Glycosyl Amides.
Authors: Yadav J. S. , Reddy B. V. Subba , Chary D. Narasimha , Madavi C. , Kunwar A. C. 
Published: March 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Structure Revision of Spiroleucettadine, a Sponge Alkaloid with a Bicyclic Core Meager in H‐Atoms.
Authors: White Kimberly N. , Amagata Taro , Oliver Allen G. , Tenney Karen , Wenzel Philip J. , Crews Phillip 
Published: March 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Evaluating the Potential of Vacuolar ATPase Inhibitors as Anticancer Agents and Multigram Synthesis of the Potent Salicylihalamide Analogue Saliphenylhalamide (V).
Authors: Lebreton Sylvain , Jaunbergs Janis , Roth Michael G. , Ferguson Deborah A. , De Brabander Jef K. 
Published: March 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Pyrrospirones A and B, Apoptosis Inducers in HL‐60 Cells, from an Endophytic Fungus, Neonectria Ramulariae Wollenw KS‐246.
Authors: Shiono Yoshihito , Shimanuki Keiko , Hiramatsu Fuminori , Koseki Takuya , Tetsuya Murayama , Fujisawa Nozomi , Kimura Ken‐ichi 
Published: March 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Spontaneous Compositional Nanopatterning in Li‐Containing Perovskite Oxides.
Authors: Guiton Beth S. , Davies Peter K. 
Published: March 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of KTaxNb1‐xO3 (KTN) Powders and Thin Films by Polymeric Precursor Method.
Authors: Simon Q. , Bouquet V. , Perrin A. , Guilloux‐Viry M. 
Published: March 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Design at the Atomic Level: Generation of Novel Hybrid Biaryloxazolidinones as Promising New Antibiotics.
Authors: Johnson Graham , et al. et al. 
Published: March 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Discovery of Novel, Potent and Bioavailable Proline‐Urea Based Macrocyclic HCV NS3/4A Protease Inhibitors.
Authors: Raboisson Pierre , et al. et al. 
Published: March 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Neutron Diffraction Study of RMn2O5 Multiferroics
Authors: Radaelli P. G. , Chapon L. C. 
Published: March 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Order Parameters and Phase Diagrams of Multiferroics
Authors: Harris A. B. , Aharony Amnon , Entin‐Wohlman Ora 
Published: March 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Nanocrystal Plasma Polymerization: From Colloidal Nanocrystals to Inorganic Architectures
Authors: Cademartiri Ludovico , Ghadimi Arya , Ozin Geoffrey A. 
Published: March 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Composite Layer‐by‐Layer (LBL) Assembly with Inorganic Nanoparticles and Nanowires
Authors: Srivastava Sudhanshu , Kotov Nicholas A. 
Published: March 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Properties of Nitro‐1,2,3‐triazoles
Authors: Vereschagin L. I. , Pokatilov F. A. , Kizhnyaev V. N. 
Published: March 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Chemical Properties of Cyanoacetanilides ad Synthesis of Biologically Active Compounds Around Them
Authors: Dyachenko V. D. , Tkachiov R. P. , Bityukova O. S. 
Published: March 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthetic Studies of Heterocyclic Natural Products
Authors: Joullie Madeleine M. , Berritt Simon , Forbeck Erin M. 
Published: March 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Aromatic Acetylation
Authors: Guisnet Michel , Guidotti Matteo 
Published: March 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Hypervalent Aryl‐, Alkynyl‐, and Alkenyl‐λ3‐bromanes
Authors: Ochiai Masahito 
Published: March 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: How Nature Morphs Reptide Scaffolds into Antibiotics
Authors: Nolan Elizabeth M. , Walsh Christopher T. 
Published: March 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Well‐Defined Polynuclear Heterobimetallic Complexes as Precursors for Ceramic and Magnetic Materials
Authors: Szafert Slawomir , John Lukasz , Sobota Piotr 
Published: March 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Candidate gene copy number analysis by PCR and multicapillary electrophoresis
Authors: Szantai Eszter , Elek Zsuzsanna , Guttman András , Sasvari‐Szekely Maria 
Published: March 2009

AbstractGenetic polymorphisms are often considered as risk factors of complex diseases serving as valuable and easily detectable biomarkers, also stable during the whole lifespan. A novel type of genetic polymorphism has been identified just recently, referred to as gene copy number variation (CNV) or copy number polymorphism. CNV of glycogen synthase kinase 3 beta and its adjacent gene, Nr1i2 (pregnane X receptor isoform), has been reported to associate with bipolar depression. In our study we introduced multicapillary electrophoresis for gene copy number analysis as an affordable alternative to real‐time PCR quantification with TaqMan gene probes. Our results show the reliability of the developed method based on conventional PCR followed by separation of products by multicapillary electrophoresis with quantitative evaluation. This method can be readily implemented for the analysis of candidate gene CNVs in high throughput clinical laboratories and also in personalized medicine care of depression‐related risk factors.
Proteomic analysis of osteogenic differentiation of dental follicle precursor cells
Authors: Morsczeck Christian , Petersen Jørgen , Völlner Florian , Driemel Oliver , Reichert Torsten , Beck Hans Christian 
Published: March 2009

AbstractRecently, there has been an increased interest in unravelling the molecular mechanisms and cellular pathways controlling the differentiation and proliferation of human stem cell lines. Proteome analysis has proven to be an effective approach to comprehensive analysis of the regulatory network of differentiation. In the present study we applied 2‐DE combined with capillary‐LC‐MS/MS analysis to profile differentially regulated proteins upon differentiation of dental follicle precursor cells (DFPCs). Out of 115 differentially regulated proteins, glutamine synthetase, lysosomal proteinase cathepsin B proteins, plastin 3 T‐isoform, beta‐actin, superoxide dismutases, and transgelin were found to be highly up‐regulated, whereas cofilin‐1, pro‐alpha 1 collagen, destrin, prolyl 4‐hydrolase and dihydrolipoamide dehydrogenase were found to be highly down‐regulated. The group of up‐regulated proteins is associated with actin‐bundling and defence against oxidative cellular stress, whereas down‐regulated proteins were associated with collagen biosynthesis. Bioinformatic analyses of the entire data set confirmed these findings that represent significant steps towards the understanding of DFPC differentiation. The bioinformatic analyses suggest that proteins associated with cell cycle progression and protein metabolism were down‐regulated and proteins involved in catabolism, cell motility and biological quality were up‐regulated. These results display the general physiological state of DFPCs before and after osteogenic differentiation. We also identified regulatory proteins, such as the transcription factors TP53 and Sp‐1, associated with the differentiation process. Further studies will investigate the impact of identified regulatory proteins for cell proliferation and osteogenic differentiation in DFPCs.
Pounding force assessment in performance‐based design of bridges
Authors: Vega Jaime , del Rey Ignacio , Alarcon Enrique 
Published: March 2009

AbstractBridges with deck supported on either sliding or elastomeric bearings are very common in mid‐seismicity regions. Their main seismic vulnerabilities are related to the pounding of the deck against abutments or between the different deck elements. A simplified model of the longitudinal behavior of those bridges will allow to characterize the reaction forces developed during pounding using the Pacific Earthquake Engineering Research Center framework formula. In order to ensure the general applicability of the results obtained, a large number of system parameter combinations will be considered. The heart of the formula is the identification of suitable intermediate variables. First, the pseudo acceleration spectral value for the fundamental period of the system (Sa(Ts)) will be used as an intensity measure (IM). This IM will result in a very large non‐explained variability of the engineering demand parameter. A portion of this variability will be proved to be related to the relative content of high‐frequency energy in the input motion. Two vector‐valued IMs including a second parameter taking this energy content into account will then be considered. For both of them, a suitable form for the conditional intensity dependence of the response will be obtained. The question of which one to choose will also be analyzed. Finally, additional issues related to the IM will be studied: its applicability to pulse‐type records, the validity of scaling records and the sufficiency of the IM. Copyright © 2009 John Wiley & Sons, Ltd.
Hepatitis B and C virus coinfection: A novel model system reveals the absence of direct viral interference #
Authors: Bellecave Pantxika , Gouttenoire Jérôme , Gajer Markus , Brass Volker , Koutsoudakis George , Blum Hubert E. , Bartenschlager Ralf , Nassal Michael , Moradpour Darius 
Published: March 2009

Abstract
Coinfection with hepatitis B virus (HBV) and hepatitis C virus (HCV) has been associated with severe liver disease and frequent progression to cirrhosis and hepatocellular carcinoma. Clinical evidence suggests reciprocal replicative suppression of the two viruses, or viral interference. However, interactions between HBV and HCV have been difficult to study due to the lack of appropriate model systems. We have established a novel model system to investigate interactions between HBV and HCV. Stable Huh-7 cell lines inducibly replicating HBV were transfected with selectable HCV replicons or infected with cell culture–derived HCV. In this system, both viruses were found to replicate in the same cell without overt interference. Specific inhibition of one virus did not affect the replication and gene expression of the other. Furthermore, cells harboring replicating HBV could be infected with cell culture–derived HCV, arguing against superinfection exclusion. Finally, cells harboring replicating HBV supported efficient production of infectious HCV. Conclusion: HBV and HCV can replicate in the same cell without evidence for direct interference in vitro. Therefore, the viral interference observed in coinfected patients is probably due to indirect mechanisms mediated by innate and/or adaptive host immune responses. These findings provide new insights into the pathogenesis of HBV–HCV coinfection and may contribute to its clinical management in the future. (Hepatology 2009.)
CCR2 promotes hepatic fibrosis in mice #
Authors: Seki Ekihiro , de Minicis Samuele , Inokuchi Sayaka , Taura Kojiro , Miyai Katsumi , van Rooijen Nico , Schwabe Robert F. , Brenner David A. 
Published: March 2009

Abstract
Chemokines and chemokine receptors contribute to the migration of hepatic stellate cells (HSCs) and Kupffer cells, two key cell types in fibrogenesis. Here, we investigate the role of CCR2, the receptor for monocyte chemoattractant protein (MCP)-1, MCP-2, and MCP-3, in hepatic fibrosis. Hepatic CCR2, MCP-1, MCP-2, and MCP-3 messenger RNA expression was increased after bile duct ligation (BDL). Both Kupffer cells and HSCs, but not hepatocytes, expressed CCR2. BDL- and CCl4-induced fibrosis was markedly reduced in CCR2−/− mice as assessed through collagen deposition, α-smooth muscle actin expression, and hepatic hydroxyproline content. We generated CCR2 chimeric mice by the combination of clodronate, irradiation, and bone marrow (BM) transplantation allowing full reconstitution of Kupffer cells, but not HSCs, with BM cells. Chimeric mice containing wild-type BM displayed increased macrophage recruitment, whereas chimeric mice containing CCR2−/− BM showed less macrophage recruitment at 5 days after BDL. Although CCR2 expressed in the BM enhanced macrophage recruitment in early phases of injury, CCR2 expression on resident liver cells including HSCs, but not on the BM, was required for fibrogenic responses in chronic fibrosis models. In vitro experiments demonstrated that HSCs deficient in CCR2−/− or its downstream mediator p47phox−/− did not display extracellular signal-regulated kinase and AKT phosphorylation, chemotaxis, or reactive oxygen species production in response to MCP-1, MCP-2, and MCP-3. Conclusion: Our results indicate that CCR2 promotes HSC chemotaxis and the development of hepatic fibrosis. (Hepatology 2009.)
Sensitivity of runoff and soil erosion to climate change in two Mediterranean watersheds. Part II: assessing impacts from changes in storm rainfall, soil moisture and vegetation cover
Authors: Nunes J. P. , Seixas J. , Keizer J. J. , Ferreira A. J. D. 
Published: March 2009

AbstractThe impacts of climate change on storm runoff and erosion in Mediterranean watersheds are difficult to assess due to the expected increase in storm frequency coupled with a decrease in total rainfall and soil moisture, added to positive or negative changes to different types of vegetation cover. This report, the second part of a two‐part article, addresses this issue by analysing the sensitivity of runoff and erosion to incremental degrees of change (from − 20 to + 20%) to storm rainfall, pre‐storm soil moisture, and vegetation cover, in two Mediterranean watersheds, using the MEFIDIS model. The main results point to the high sensitivity of storm runoff and peak runoff rates to changes in storm rainfall (2·2% per 1% change) and, to a lesser degree, to soil water content (−1·2% per 1% change). Catchment sediment yield shows a greater sensitivity than within‐watershed erosion rates to both parameters: 7·8 versus 4·0% per 1% change for storm rainfall, and − 4·9 versus − 2·3% per 1% change for soil water content, indicating an increase in sensitivity with spatial scale due to changes to sediment connectivity within the catchment. Runoff and erosion showed a relatively low sensitivity to changes in vegetation cover. Finally, the shallow soils in one of the catchments led to a greater sensitivity to changes in storm rainfall and soil moisture. Overall, the results indicate that decreasing soil moisture levels caused by climate change could be sufficient to offset the impact of greater storm intensity in Mediterranean watersheds. Copyright © 2009 John Wiley & Sons, Ltd.
Biological response of osteoblast‐like UMR‐106 cells to the modified PHBV matrix—Effects of porosity and collagen dip coating
Authors: Liu Hui , Raghavan Dharmaraj , Melaku Samuel , Stubbs John 
Published: March 2009

AbstractIn this study, we related porosity and collagen coating of poly(3‐hydroxybutyrate‐co‐3‐hydroxyvalerate) (PHBV) scaffold to the degree of cell proliferation on the engineered PHBV scaffold. Based on the [3‐(4,5‐dimethylthiazol‐2‐yl)‐5‐(3‐carboxymethoxyphenyl)‐2‐(4‐sulfophenyl)‐2h‐tetrazolium, inner salt] (MTS) assay, we established that UMR‐106 cell proliferation is maximum in collagen‐coated porous PHBV film followed by porous PHBV film and least in nonporous PHBV film. RT‐PCR analysis of the proliferated cells on tissue culture polystyrene (TCPS) and porous and nonporous PHBV scaffolds revealed that the proliferated cells retained their osteoblastic phenotype characteristics. Atomic absorption analysis was performed to measure the extent of calcium conversion by the cells grown on PHBV and TCPS. The calcium content of the culture media was used to indirectly measure the mineralization ability of the cells. The extent of calcium conversion by the cells was found to depend on the incubation time. Based on the results of the study, modified PHBV matrix seems to be a suitable matrix candidate for bone tissue engineering application. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res, 2010
bFGF‐loaded HA‐chitosan: A promising scaffold for periodontal tissue engineering
Authors: Akman Abdullah C. , Tığlı R. Seda , Gümüşderelioğlu Menemşe , Nohutcu Rahime M. 
Published: March 2009

AbstractA scaffold containing growth factors promoting regeneration may be a useful device to maintain periodontal regeneration when applied with appropriate cells. The aim of this study is to evaluate the convenience of chitosan and hydroxyapatite (HA)‐chitosan scaffolds loaded with basic fibroblast growth factor (bFGF) for periodontal tissue engineering applications. Scaffolds were fabricated by freeze‐drying technique using 2 and 3% chitosan gel in the absence or presence of HA particles. Addition of HA beads to chitosan gels produced a novel scaffold in which the pore sizes and interconnectivity were preserved. The scaffolds were loaded with 100 ng bFGF by embedding technique. HA‐chitosan scaffolds provide better controlled release kinetics for bFGF compared with chitosan scaffolds and total release continued up to 168 h. Cell culture studies were carried out with periodontal ligament (PDL) cells and cementoblasts. Both 3‐[4,5‐dimethylthiazol‐2‐yl]‐diphenyltetrazolium bromide (MTT) assay and confocal laser scanning microscope analysis revealed cells proliferating inside the scaffolds. The results demonstrated that bFGF‐loaded HA‐chitosan scaffolds provide a suitable three‐dimensional environment supporting the cellular structure, proliferation, and mineralization. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res, 2010