bluuebunny/crossref_metadata_2025_split huggingface dataset:
General vertex-degree-based topological indices of Graphene Oxide (C 140 H 42 O 20 ) graphs with advanced entropies
Authors: Kamran Muhammad , Salamat Nadeem , Nadeem Muhammad , CANGUL Ismail Naci , Farman Muhammad 
Published: March 2024

Abstract
Nanomaterials have been widely used in a number of sectors during the past few decades, including electronics, pharmaceuticals , cosmetics, food processing, construction, and aeronautics. These nanomaterials may improve approaches for therapy, diagnosis, and prevention in the medical field. Graphene oxide (GO), an oxidised derivative of graphene, is now used in biotechnology and medicine for the treatment of cancer, drug delivery, and cellular imaging. Large surface area, electrical charge, and nanoscale size are other physicochemical properties of GO. The factors that are crucial for QSAR and QSPR analyses are topological indices. Shannon’s entropy measures, which characterise graphs by looking at the structure information of graphs and networks, are the primary type of topological indices now in use.Graph theory, biology, and chemistry are just a few of the disciplines that employ the graph entropy measurements. Two examples of thermodynamic entropy utilised in the molecular dynamics research of complicated chemical systems are the configuration entropy of glass-forming liquids or the thermodynamic entropy of enzyme-substrate complexations. In this paper, several degree-based entropies calculated using topological indices. The required outcomes were obtained by combining curve fitting between determined information entropies and topological indices with numerical and graphical representations of computed findings. Learn about the entropy-based symmetry analysis of the topological indices. The system is based on topological indices, which offer a thorough overview of all potentially important factors that may be important in structurally changing (C140H42O20) for certain applications.
Mathematics Subject Classification: 05C09, 05C92, 05C07, 92E10
Amino Acids Composition of V. Doniana and S. Comorensis Fruits
Authors: Charles Dominic , MGINA CLARENCE 
Published: March 2024

Abstract
The amino acids composition of S. comorensis and V. doniana fruits were investigated in this study. The analysis was done using Liquid Chromatography - Mass Spectrometry (LC-MS). It was found that the various essential amino acids in S. comorensis fruits ranged from 0.01 ± 0.18 mg/kg to 55.01 ± 2.15 mg/kg and V. doniana fruits ranged from 0.023 ± 0.00 mg/kg to 88.64 ± 0.87 mg/kg. For each of the plant fruits there were no significant differences in terms of amino acids amounts between the two regions (P > 0.05) except for phenylalanine in V. doniana. The phenylalanine content in V. doniana ranged from 51.36 mg/kg to 53.14 mg/kg for the fruit samples from Pwani and 39.61 mg/kg to 39.87 mg/kg for the fruit samples from Tanga with a significant difference between the two regions {P < 0.05). Leucine was the most abundant essential amino acid in S. comorensis fruits with a range between 44.78 mg/kg and 51.42 mg/kg for the fruit samples from Tanga region and 52.86 mg/kg to 57.16 mg/kg for the fruit’s samples from Pwani region with no significant difference (P > 0.05) in content between two regions. It was notable that lysine, histidine and threonine ware not detected in any of the samples from the two species. The study shows that these fruits are potential essential amino acids food sources and can complement with other sources to make a balanced diet for a healthy human body.
Novel double structural transition at room temperature in Bi1-xGdxFeO3 system prepared by sol-gel method
Authors: Dinia S. , El-Bey A. , Oubla M. , Taibi M. , Elbahraoui T. , Atourki L. , Belayachi W. , Abd-Lefdil M. 
Published: March 2024

Abstract
Bi1-xGdxFeO3 \(\text{p}\text{o}\text{w}\text{d}\text{e}\text{r}\text{s} \text{w}\text{i}\text{t}\text{h} 0.00\le x\le 0.20\) were successfully synthesized by sol-gel process. X-ray analyses revealed the existence of a double structural transition from rhombohedral to cubic symmetry for \(x=0.10\) (first transition) and from cubic to orthorhombic symmetry for \(x\ge 0.15\) (second transition). Infrared spectroscopy allows the identification of different bending and stretching vibrations between the different ions. Magnetization hysteresis loops, recorded at room temperature, indicate a typical ferromagnetic-like behaviour. Additionally, differential scanning calorimetry measurements were also performed and discussed.
Genetic risk assessment of HLA DRB1 alleles (01, 04, 12 and 15) with Rheumatoid arthritis susceptibility among the Pashtun population of Khyber Pakhtunkhwa, Pakistan
Authors: Ilahi Zahoor , Khan Najeeb Ullah , Khan Hamza , Almutairi Mikhlid H. , Ali Ijaz 
Published: March 2024

Abstract
Background: Rheumatoid arthritis (RA) is a chronic autoimmune condition influenced by a complex interplay of genetic and environmental factors. Specific genetic variations, particularly in the human leukocyte antigen (HLA)-DRB1 gene, have been strongly linked to RA susceptibility. HLA-DRB1 alleles, part of the major histocompatibility complex (MHC) class II gene family, play a significant role in the immune system.
Aims: This study aimed to investigate the association between HLA-DRB1*01, *04, *12, and *15 alleles and RA risk within the Pashtun population of Pakistan.
Methods: A cohort of 100 RA patients and 80 healthy controls was recruited for this study. DNA was isolated from blood samples using the salting-out method, followed by genotyping using sequence-specific primer polymerase chain reaction (SSP-PCR). The association of the selected alleles with clinicopathological and demographic parameters of RA was assessed using the Medcalc odds ratio calculator and Chi-square test.
Results: Allelic and genotypic analysis revealed that HLA-DRB1 *01 and *04 variants exhibited non-significant associations with RA risk (P=0.1421 and 0.8495, respectively). Similarly, mutant genotypes of HLA-DRB1 *01 and *04 showed non-significant associations with RA (P=0.2922 and P=0.8263, respectively). However, the heterozygous CA genotype of HLA-DRB1 *01 demonstrated a significant association with RA (P=0.0004), whereas HLA-DRB1 *04 did not (P=0.9120). Furthermore, HLA-DRB1 *12 showed a significant association with increased RA risk (P=0.0001), while HLA-DRB1 *15 did not (P=0.5519). Additionally, HLA-DRB1*01, *04, and *12 did not show significant associations with age group (P=0.08, P=0.11, P=0.16) and rheumatoid factor (RF) status (P=0.34, P=0.65, and P=0.74), whereas HLA-DRB1 *15 exhibited non-significant associations with age group and RF (P=0.01 each). Moreover, associations of HLA-DRB1 *01, *04, *12, and *15 with gender (P=0.81, P=0.52, P=0.27, and P=0.09, respectively) and anti-citrullinated protein antibody (ACPA) status (P=0.56, P=0.40, P=0.65, and P=0.008, respectively) were not significant, except for HLA-DRB1 *04, which displayed a significant association with ACPA.
Conclusion: HLA-DRB1 *12 and heterozygous genotypes of HLA-DRB1 *01 were significantly associated with RA risk in the Pashtun population. However, further analysis utilizing whole exome sequencing with larger datasets is warranted for more precise results.
Based on improved YOLOv8 and Bot SORT surveillance video traffic statistics
Authors: Yang Yiqun , Pi Daneng , Wang Lingyan , Bao Mingliang , Ge Jianfu , Yuan Tingchen , Yu Houshi , Zhou Qi 
Published: March 2024

Abstract
Aiming at the problems of leakage detection and low detection accuracy of existing deep learning based surveillance video traffic flow detection algorithms, a traffic flow counting system combining improved YOLOv8 detection and Bot SORT tracking is proposed. First, the backbone network is used to incorporate the SPD-Conv convolutional layer to improve the network's ability to detect small targets. Then, the attention mechanism CoTAttention is introduced into the neck network to further improve the model generalization ability. Finally, the improved YOLOv8 model and the Bot SORT algorithm are combined to design and implement a traffic counting system capable of monitoring video traffic in real time, and trained and tested on the open-source UA-DETRAC vehicle detection dataset. The experimental results show that the improved YOLOv8 algorithm improves F1, P, mAP50, and mAP50-95 by 0.36, 2.2, 1.8, and 2.1 percentage points, respectively, compared with the original algorithm. Combined with the Bot SORT tracking, it achieves more accurate and reliable results in the task of traffic counting, which provides a strong support for the vehicle detection and counting in the monitoring system.
A Task Offloading Decision and Resource Allocation Algorithm Based on DDPG in Mobile Edge Computing
Authors: Li An , Zheng Yeqiang , Nong Wang , Wang Gaocai , Huang Shuqiang 
Published: March 2024

Abstract
In mobile edge computing, the mobile device can offload tasks to the server near the edge of the mobile network for execution, thereby reducing the delay of task execution and the energy consumption of mobile device. However, limited resource of the edge server prevents the mobile device to offload all tasks to the edge servers for execution. To solve the problems, a mobile edge computing model of multi-users and single edge server is constructed in this paper. In order to minimize the weighted total cost composed of mobile device energy consumption and time delay under the constraints of task execution delay, computing resource and storage resource of the edge server, we propose a task offloading decision and resource allocation algorithm OADDPG based on Deep Deterministic Policy Gradient (DDPG). A special reward function is designed to make the reward value for correlating negatively with the total cost. We can get the lowest total cost when the algorithm reaches the maximum reward value. Experiment results show that the proposed algorithm can effectively reduce the weighted total cost of mobile devices and improve the success rate of task execution.
Modeling on comprehensive evaluation of groundwater quality status using Geographic Information System (GIS) and Water Quality Index (WQI): a case study of Bahir Dar City, Amhara, Ethiopia
Authors: Alemu Chalachew Mulat , Aycheh Yibeltal Fentahun , Angualie Gashaw Sintayehu , Engidayehu Selamawit Sewunet 
Published: March 2024

Abstract
Groundwater is the most important natural resource, and many people throughout the world rely on it for drinking, particularly in rural areas. The present study was carried out to assess the status of groundwater quality and to check its suitability for domestic purposes in urban centres of Bahir Dar City, Ethiopia. Twelve shallow wells were selected for sampling. The sampled water was taken during the dry and summer seasons of the year 2019/2020. pH, turbidity, EC, TDS, chloride (Cl−), nitrate (NO3−), phosphate (PO4−3), total hardness, and Escherichia coli were measured for the suitability analysis. Comparison of measured results with those of WHO and Ethiopian drinking water quality standards was done. Moreover, Geographic Information System (GIS) and Water Quality Index (WQI) data analysis techniques were applied in order to investigate the groundwater quality. The spatial distribution map showed that the city's core area had the poorest groundwater quality status. The WQI result obtained from the analysis showed that 41.67, 33.33, and 25% of the sampled groundwater has low, extremely poor, and unsafe quality for drinking purposes, respectively. The present study revealed that anthropogenic activities have a great impact on the quality of groundwater in the area, necessitating immediate mitigating actions.
Congenital Abdominal Aortic Aneurysm: Presentation, Etiology, Diagnosis and
Management
Authors: Al-Askari Majd R. , Patni Mohamed Anas Mohamed Faruk , Krayem Yaman , Ejaz Abdullah 
Published: March 2024

Abstract:
Aortic aneurysms are common in adults due to atherosclerosis but are rare in children and young adults, often overlooked due to infrequent
reporting. Acquired aneurysms are usually linked to factors like umbilical artery ligation, connective tissue diseases, or vasculitides. In contrast, the
causes of congenital abdominal aortic aneurysms (AAA) remain unknown due to their extreme rarity. Only a few cases have been reported. Prompt
diagnosis is essential when symptoms such as abdominal distention, vomiting, or abdominal pulsatility occur. Diagnosis is typically confirmed
through ultrasonography and multi-slice spiral computed tomography angiographies (MCSTA). After detection, a comprehensive investigation is
necessary to rule out acquired AAA causes. Managing congenital AAA requires a highly personalized approach, with early surgical repair using
grafts as a recommended option. After an extensive analysis of numerous academic sources, we have comprehensively understood the
epidemiology, clinical features, and diagnostic and treatment techniques for congenital abdominal aortic aneurysms.
A Novel Electrochemiluminescence (ECL) Immunoassay for the Quantitation
of Monoclonal Antibody (mAb) PYX-106 in Human Serum
Authors: Yin Feng , Adhikari Diana , Liu Xiaodong F. , Wang Jianxin , Yang Wensheng , Balogh Gabriela A. , Simon Teri , Lei Wenji , Squicciarini Mariana , Bruce Lisa , Ke Yan , Dyszel Mike , Harriman Shawn , Pinkas Jan 
Published: March 2024

Background::
PYX-106 is a novel monoclonal antibody (mAb), targeting the sialic acidbinding
immunoglobulin-like lectin 15 (Siglec-15) in the Tumor Microenvironment (TME). Precise
measurement of PYX-106 is essential for the thorough assessment of PYX-106 pharmacokinetics
in clinical investigations.

Methods::
A novel Electrochemiluminescence (ECL) immunoassay for the quantitation of PYX-
106 in human serum was developed and validated. Biotinylated anti-PYX-106 antibody Bio-A1A1
was employed as the capture antibody, and ruthenylated anti-PYX-106 antibody Ru-A3G10 was
utilized as the detection antibody in the ECL immunoassay on Meso Scale Discovery (MSD) platform.

Results::
This assay was fully validated in terms of selectivity, accuracy, precision, hook effect,
stability, etc., with a dynamic range from 50.0 to 2,500 ng/mL in human serum under the 2018
U.S. Food and Drug Administration (FDA) guidance and the 2022 U.S. FDA ICH M10 guidance.

Conclusion::
PYX-106 bioanalytical assay validation was reported for the first time in a biological
matrix, and this assay has been successfully applied to support a clinical trial PYX-106-101.
Urinary Tract Infection by Aspergillus Species in Post-Menopausal Woman
Authors: Shukla Manisha , Vishwakarma Rohit Kumar , Chauhan Neha 
Published: March 2024

Background:
Urinary tract infection by Aspergillus species is an uncommon but potentially serious complication in post-menopausal women, often associated
with recurrent UTIs or immunocompromise.

Case Presentation:
We present a case of a deceased 67-year-old female with complaints of fever, abdominal pain, diabetes, hypertension, pain and burning during
urination admitted to hospital. Microscopic examination confirmed the Aspergillus infection. The patient could not be followed up due to COVID.

Discussion:
Urinary Tract infection with Aspergillus species is few and far occurrence. Especially combined with a medical history of non-immune
compromises like diabetes, kidney dysfunction and hypertension. Voriconazole anti-fungal medicine worked well on patients with improved
conditions. In spite of diabetes and other medical conditions, neutrophils and total lymphocyte count showed elevated levels, which need further
studies.

Conclusion:
Prompt diagnosis and targeted antifungal therapy are essential in managing urinary tract infections caused by Aspergillus species in postmenopausal
women to prevent complications.
Dziecko hospitalizowane z powodu obturacyjnego zapalenia oskrzeli - studium indywidualnego przypadku
Authors: Waligórska Martyna 
Published: March 2024

Wstęp. Obturacyjne zapalenie oskrzeli to charakterystyczna postać zakażenia układu oddechowego. Dochodzi do zwężenia światła oskrzeli oraz nadprodukcji śluzu w drogach oddechowych, w wyniku czego występuje duszność stanowiąca zagrożenie życia dziecka. Objawy zapalenia mogą być różne w zależności od czynnika etiologicznego wywołującego chorobę. Do głównych objawów należą kaszel, stany podgorączkowe, nasilony obrzęk dróg oddechowych, duszność oraz zwiększone gromadzenie wydzieliny śluzowej. Zapalenie oskrzeli z obturacją częściej diagnozuje się u dzieci ze względu na ich niedojrzałość układu oddechowego oraz niewykształconą odporność. Najwięcej zachorowań występuje w przypadku dzieci uczęszczających do przedszkola czy żłobka. Częstym zjawiskiem są nawroty choroby, głównie w okresie jesienno-zimowym.
Cel. Celem niniejszej pracy jest przedstawienie zakresu zadań pielęgniarki pediatrycznej, zastosowanych wobec dziecka z obturacyjnym zapaleniem oskrzeli oraz zaprezentowanie problemów pielęgnacyjnych, wynikających z choroby.
Prezentacja przypadku. Chłopiec, 6-miesięczny, przyjęty w oddział pediatryczny w stanie ogólnym średnim w pierwszej dobie hospitalizacji z powodu duszności wydechowej oraz utrzymującej się podwyższonej temperatury ciała. Z przeprowadzonych badań laboratoryjnych zgodnie ze zleceniem lekarskim uzyskano podwyższone wskaźniki odpowiedzialne za stan zapalny w organizmie. U chłopca zdiagnozowano obturacyjne zapalenie oskrzeli. Od kilku dni występuje suchy, męczący kaszel wraz z odruchami wymiotnymi przy jego nasilaniu. Udokumentowano temperaturę ciała dziecka w wysokości 39,0°C. Chłopiec jest niespokojny, zaobserwowano niechęć do przyjmowania posiłków. Pacjent oraz jego opiekunowie wykazują ogólny niepokój związany z koniecznością hospitalizacji. Rodzice chłopca wykazują deficyt wiedzy na temat zakażeń układu oddechowego i profilaktyki nawrotów choroby.
Wnioski. Problemy pielęgnacyjne dziecka ze zdiagnozowanym obturacyjnym zapaleniem oskrzeli wymagają obecności i opieki całego zespołu terapeutycznego, ponieważ występująca duszność stanowi zagrożenie dla życia dziecka. Problemy stwierdzone u pacjenta to: zaburzenia oddychania z powodu utrzymującej się duszności, nieefektywne odkrztuszanie zalegającej wydzieliny oskrzelowej, ryzyko odwodnienia na skutek podwyższonej temperatury ciała, ryzyko utraty masy ciała z powodu niechęci do przyjmowania pokarmów, ryzyko infekcji, jak również potrzeba kompleksowej edukacji rodziców dziecka na temat choroby i profilaktyki.
STRATEGI KOMUNIKASI PEMASARAN DALAM MEMPROMOSIKAN OBJEK WISATA PUNTHUK SETUMBU
Authors: Zulaefa Eva , Suranto Suranto 
Published: March 2024

Penelitian ini bertujuan untuk mendiskripsikan: 1) strategi komunikasi pemasaran yang dilakukan oleh Badan Pengelola Wisata Alam dan Sunrise Punthuk Setumbu dalam mempromosikan objek wisata Punthuk Setumbu; 2) media yang digunakan untuk mempromosikan objek wisata Punthuk Setumbu. Penelitian ini menggunakan metode penelitian dengan pendekatan kualitatif. Penelitian ini dilaksanakan di objek wisata Punthuk Setumbu, Kabupaten Magelang. Informan penelitian adalah bagian pemasaran, ketua pengelola dan pengunjung objek wisata Punthuk Setumbu. Pengumpulan data dilakukan dengan wawancara, observasi dan dokumentasi. Analisis data dilakukan melalui pengumpulan data, reduksi data, sajian data dan penarikan kesimpulan. Pemeriksaan keabsahan data dilakukan dengan triangulasi sumber. Hasil penelitian menunjukkan: 1) pengelola objek wisata Punthuk Setumbu dalam melakukan kegiatan komunikasi pemasaran, menggunakan strategi yaitu a) khalayak sasaran objek wisata Punthuk Setumbu yaitu wisatawan nusantara dengan segmen fotografer dan wisatawan usia 16-30 tahun b) tujuan yang ingin dicapai yaitu meningkatkan kunjungan wisatawan, membangun brand awaraness dan meningkatkan pendapatan, c) pesan yang disampaikan melalui media cetak yaitu berupa informasi fasilitas dan foto-foto, sedangkan media sosial dengan mengajak wisatawan tag foto ke akun instagram Punthuk Setumbu d) saluran personal berupa pameran dan promosi langsung ke tour guide dan driver,sedangkan saluran non personal melalui media cetak dan media elektronik e) anggaran promosi ditetapkan dengan metode tujuan dan tugas, f) bauran promosi yang digunakan yaitu periklanan, promosi penjualan, acara pengalaman, humas publisitas, pemasaran langsung, pemasaran dari mulut ke mulut dan penjualan personal, g) mengukur hasil promosi dilakukan dengan melihat data kunjungan wisatawan, h) dalam mengkoordinasi proses komunikasi yang terintegrasi, semua dilakukan oleh bagian pemasaran. 2) media yang digunakan untuk mempromosikan objek wisata Punthuk Setumbu adalah media cetak, media elektronik dan media sosial.Kata Kunci: Strategi Komunikasi Pemasaran, Promosi Pariwisata, Punthuk Setumbu
Mengembangkan potensi diri untuk remaja introvert melalui konten kreasi Youtube
Authors: Irghansyah Rajiv , Aulia Fernanda Putri , Sabri Sabri 
Published: March 2024

Abstrak Introvert adalah salah satu tipe kepribadian yang lebih fokus pada pikiran, suasana hati,dan perasaan secara internal. Tipe introvert lebih cenderung menyukai waktu bersama satu atau dua orang.Penyebab introvert seperti aspek kepribadian sebagai kombinasi dari dua faktor utama yakni gen an lingkungan. Remaja introvert dapat mengembangkan potensi mereka melalui Youtube. Di Youtube mereka dapat membuat video sekreatif mungkin sehingga mereka dapat menarik banyak pemirsa dan menjadi lebih terkenal. Tujuan penelitian ini agar dapat memotivasi remaja introvert untuk mengembangkan potensi dirinya melalui konten Youtube dan mereka mendapat relasi yang lebih luas. Pada penelitian ini menggunakan metode penelitian kualitatif dengan jenis penelitian deskriptif, dimana pemecahan masalah yang diselidiki dengan menggambarkan subjek atau objek dapat berupa orang, lembaga, masyarakat, dan lainnya yang berdasarkan fakta-fakta. Manfaat dari penelitian ini agar memperluas wawasan bagi orang introvert tentang media sosial Youtube, yang memudahkan remaja introvert dalam mengembangkan potensi diri.Kata kunci : Potensi diri, Remaja, Youtube, Komunikasi. Abstract Introvert is a personality type that is more focused on thoughts, moods, and feelings internally. Introverts tend to prefer time with one or two people. The causes of introverts are like aspects of personality as a combination of two main factors, namely genes and the environment. Introverted youth can develop their potential through Youtube. On Youtube they can make videos as creative as possible so they can attract a lot of viewers and become more famous. The purpose of this research is to motivate introverted youth to develop their potential through Youtube content and they get wider relationships. In this study, a qualitative research method was used with a descriptive research type, in which the problem solving investigated by describing the subject or object could be in the form of people, institutions, communities, and others based on facts. The benefit of this research is to broaden insight for introverts about Youtube social media, which makes it easier for introverted youth to develop their own potential.Keywords : Self potential, Youth, Youtube, Communication