bluuebunny/crossref_metadata_2025_split huggingface dataset:
Awareness, experiences, and opinions by owners, breeders, show judges, and veterinarians on canine Brachycephalic Obstructive Airway Syndrome (BOAS)
Authors: Åsbjer Elina , Hedhammar Åke , Engdahl Karolina 
Published: March 2024

Abstract
Background
Exaggerated brachycephalic features have been highlighted over the last decade by their profound effect on the health and welfare of the affected dogs. The term brachycephalic obstructive airway syndrome (BOAS) was launched in the early 2000s and has received worldwide attention and awareness. At the same time, the popularity of brachycephalic dogs increased. This study aimed to reveal the awareness and experiences of health issues related to the physical appearance of brachycephalic breeds and compare perceptions and opinions on how to counteract these issues by various stakeholders (dog owners, veterinarians, dog breeders, and show judges) by performing an online survey.

Results
Altogether, 1602 owners, 1551 breeders, 118 show judges, and 557 veterinarians participated. Awareness and experiences of conformation-related health issues were common among all stakeholder groups. Most participants agreed fully or partly that health issues related to conformity threaten the health of brachycephalic breeds; that the measures taken so far are positive; and that guidelines on the appearance of a dog should be based on knowledge regarding health issues related to physical appearance. A disagreement was noted on further measures to be taken and the importance of adhering to a breed standard.

Conclusions
All stakeholders were aware of health issues related to the appearance of brachycephalic dogs, but had variable personal experiences of these issues. Most participants agreed fully or partly that health issues related to conformity threaten the health of brachycephalic breeds, and that attention to these issues and measures taken so far are positive. However, there is a disagreement on further actions to be taken and the importance of adhering to a breed standard. These findings could be used to understand and bridge the gap in opinions between stakeholders and to refine methods to influence the health of dogs with exaggerated brachycephalic features.
Impact of age on the host response to sepsis in a murine model of fecal-induced peritonitis
Authors: Sharma Neha , Chen Alex , Heinen Leah , Liu Ruth , Dwivedi Dhruva J. , Zhou Ji , Lalu Manoj M. , Mendelson Asher A. , McDonald Braedon , Kretz Colin A. , Fox-Robichaud Alison E. , Liaw Patricia C. 
Published: March 2024

Abstract
Introduction
Despite older adults being more vulnerable to sepsis, most preclinical research on sepsis has been conducted using young animals. This results in decreased scientific validity since age is an independent predictor of poor outcome. In this study, we explored the impact of aging on the host response to sepsis using the fecal-induced peritonitis (FIP) model developed by the National Preclinical Sepsis Platform (NPSP).

Methods
C57BL/6 mice (3 or 12 months old) were injected intraperitoneally with rat fecal slurry (0.75 mg/g) or a control vehicle. To investigate the early stage of sepsis, mice were culled at 4 h, 8 h, or 12 h to investigate disease severity, immunothrombosis biomarkers, and organ injury. Mice received buprenorphine at 4 h post-FIP. A separate cohort of FIP mice were studied for 72 h (with buprenorphine given at 4 h, 12 h, and then every 12 h post-FIP and antibiotics/fluids starting at 12 h post-FIP). Organs were harvested, plasma levels of Interleukin (IL)-6, IL-10, monocyte chemoattract protein (MCP-1)/CCL2, thrombin-antithrombin (TAT) complexes, cell-free DNA (CFDNA), and ADAMTS13 activity were quantified, and bacterial loads were measured.

Results
In the 12 h time course study, aged FIP mice demonstrated increased inflammation and injury to the lungs compared to young FIP mice. In the 72 h study, aged FIP mice exhibited a higher mortality rate (89%) compared to young FIP mice (42%) (p < 0.001). Aged FIP non-survivors also exhibited a trend towards elevated IL-6, TAT, CFDNA, CCL2, and decreased IL-10, and impaired bacterial clearance compared to young FIP non-survivors.

Conclusion
To our knowledge, this is the first study to investigate the impact of age on survival using the FIP model of sepsis. Our model includes clinically-relevant supportive therapies and inclusion of both sexes. The higher mortality rate in aged mice may reflect increased inflammation and worsened organ injury in the early stage of sepsis. We also observed trends in impaired bacterial clearance, increase in IL-6, TAT, CFDNA, CCL2, and decreased IL-10 and ADAMTS13 activity in aged septic non-survivors compared to young septic non-survivors. Our aging model may help to increase the scientific validity of preclinical research and may be useful for identifying mechanisms of age-related susceptibility to sepsis as well as age-specific treatment strategies.
Market risk spillover and the asymmetric effects of macroeconomic fundamentals on market risk across Vietnamese sectors
Authors: Vo Duc Hong , Nguyen Hung Le-Phuc 
Published: March 2024

AbstractGlobal economic downturns and multiple extreme events threaten Vietnam's economy, leading to a surge in stock market risk and significant spillovers. This study investigates market risk spillovers and explores the asymmetric effects of macroeconomic indicators on market risk across 24 sectors in Vietnam from 2012 to 2022. We use the value-at-risk (VaR) technique and a vector autoregression (VAR) model to estimate market risks and their spillovers across Vietnamese sectors. We then examine the asymmetric effects of macroeconomic indicators on market risk using a panel nonlinear autoregressive distribution lag (NARDL) model. Our results confirm that Vietnam’s market risk increases rapidly in response to extreme events. Additionally, market risks exhibit substantial inter-connectedness across the Vietnamese sectors. The Building Materials, Technology, and Securities sectors are primary risk transmitters, whereas the Minerals, Development Investment, and Education sectors are major risk absorbers. Our results also confirm that market risk responds asymmetrically to changes in interest rates, exchange rates (USD/VND), trade openness, financial development, and economic growth in the short and long run. Minerals, Oil & Gas, and Rubber are the sectors that are most affected by macroeconomic indicators in the long run. Based on these important findings, implications focused on limiting market risks and their spillovers, along with sustainable investing, have emerged.
Brain death: a review
Authors: Abdelbari Mattar Mohamed , Mohamed Zakwan Zakaria 
Published: March 2024

Abstract
Background
To date, the recognized medical criteria for BD/DNC (brain death/death according to neurological criteria) in the USA (United States of America) are the 2010 AAN (American Academy of Neurology) standards for identification of the BD/DNC for adult age and the 2011 Society of Critical Care Medicine/Child Neurology Society/American Academy of Pediatrics standards for identification of BD/DNC in Pediatrics.

Main body
Though the definition of death should be constant between clinicians, hospitals, and nations to endorse that whoever is considered dead somewhere will not be regarded as alive in another place. This provoked the construction of the worldwide Brain Death Project that declared a global agreement report on the BD/DNC which is accredited by 5 international federations and 27 medical professional communities from all over the world. This review defines the essential requirements of BD/DNC, its assessment (including apnea test) on a clinical basis, usage of additional examinations, and the arguments for its definition worldwide.

Conclusion
A precise and unbiased methodology is necessary to issue error-free declarations of death by defining BD/DNC while considering local regulations and values. Practitioners must learn to be familiar with the current guidelines, and the contents of the WBDP (world Brain Death Project) standard, which announces an updated International Agreement Report on BD/DNC and certified by 5 International federations and 27 professional medical communities from all over the world.
Improving household water treatment: using zeolite to remove lead, fluoride and arsenic following optimized turbidity reduction in slow sand filtration
Authors: Onyutha Charles , Okello Emmanuel , Atukwase Rebecca , Nduhukiire Pamella , Ecodu Michael , Kwiringira Japheth Nkiriyehe 
Published: March 2024

AbstractDespite the United Nations 2030 agenda, large number of both urban and rural dwellers in low-income countries continue to lack access to improved water. Thus, increased effort is required towards enhancing low-cost drinking water treatment technologies especially for developing countries. Slow sand filter (SSF) is one of the most commonly used low-cost and efficient technologies for treating household drinking water. However, effectiveness of SSF is substantially affected by very high turbidity and relatively large amounts of dissolved heavy metals. To enhance removal of both turbidity and heavy metals, this study optimized sand bed depth (SBD) of SSF and investigated the potential of natural zeolite from Uganda for removal of lead, arsenite (As(III)) and fluoride ions from water. To remove lead ions, the zeolite was used in its natural form. However, to remove As(III) and fluoride, the natural zeolite was modified using hexadecyltrimethylammonium bromide solution. Removal of high turbidity was found to require a large optimal SBD. Furthermore, efficiency of treating synthetic turbid water increased with increasing initial turbidity. Variation of final turbidity with SBD was found to be best described by an exponential function. Optimal SBDs on top of an underdrain gravel layer of 0.2 m were 453, 522, 561, and 580 mm for turbidity of 60, 80, 100, and 120 NTU, respectively. Optimized SBD used achieve at least 95% efficiency in removing suspended particles from water with turbidity 120 NTU was found to save up to 35% of the total cost for acquiring sand volume required by a conventional SSF. For a particular zeolite mass, removal efficiencies of lead, As(III) and fluoride generally increased with increasing contact time. Removal efficiencies of lead, As(III), and fluorides were also shown to increase with increasing zeolite mass. Lead removal efficiencies using natural zeolite were 75 and 98% under 20 and 40 min, respectively. Removal of As(III) using modified zeolite mass was 91% within contact time of 10 min. Adsorption of fluoride on modified zeolite was 80% within 5 min. Adsorption of lead, As(III), and fluorides indicated promising potential of natural zeolites from Uganda for treating polluted water.
Addition of vancomycin to cefazolin is often unnecessary for preoperative antibiotic prophylaxis during total joint arthroplasties
Authors: Bains Sandeep S. , Dubin Jeremy A. , Hameed Daniel , Chen Zhongming , Moore Mallory C. , Shrestha Ashesh , Nace James , Delanois Ronald E. 
Published: March 2024

Abstract
Purpose
The gold standard to decrease total joint arthroplasty (TJA) periprosthetic joint infection (PJI) is preoperative antibiotic prophylaxis. Despite substantial prevention efforts, rates of PJIs are increasing. While cefazolin is the drug of choice for preoperative prophylaxis, adjunctive vancomycin therapy has been used in methicillin-resistant Staphylococcus aureus (MRSA) endemic areas. However, studies examining these combinations are lacking. Therefore, we sought to examine complications among vancomycin plus cefazolin and cefazolin-only recipients prior to primary TJA in a single institutional sample and specifically assessed: (1) microbiological aspects, including periprosthetic joint and surgical site infections, microbes cultured from the infection, and frequency of microbes cultured from nasal swab screening; (2) 30-day emergency department (ED) visits and re-admissions; as well as (3) associated risk factors for infection.

Methods
A total of 2,907 patients (1,437 receiving both cefazolin and vancomycin and 1,470 given cefazolin only) who underwent primary TJA between 1 January 2014 and 31 May 2021 were identified. SSI and PJI as well as rates of cultured microbes rates were obtained through one year, those with prior nasal swab screening and 30-day re-admission were identified. Subsequently, multiple regression analyses were performed to investigate potential independent risk factors for PJIs.

Results
There was no significant difference in the rates of SSI (P = 0.089) and PJI (P = 0.279) between the groups at one year after operation. Commonly identified organisms included Staphylococcus and Streptococcus species. The VC cohort did have a greater reduction of MRSA in the previously nasal swab-screened subset of patients. Multiple regression analyses demonstrated emergency as well as inpatient admissions as risk factors for PJI.

Conclusions
Adjunctive vancomycin therapy offers increased protection against MRSA in previously screened individuals. However, those negative for MRSA screening do not require vancomycin and have similar protection to infection compared to recipients of cefazolin only in a high-powered single institution analysis in an MRSA endemic area.
HER2 Gene Expression Levels Are Predictive and Prognostic in Patients With Metastatic Colorectal Cancer Enrolled in CALGB/SWOG 80405
Authors: Battaglin Francesca , Ou Fang-Shu , Qu Xueping , Hochster Howard S. , Niedzwiecki Donna , Goldberg Richard M. , Mayer Robert J. , Ashouri Karam , Zemla Tyler J. , Blanke Charles D. , Venook Alan P. , Kabbarah Omar , Lenz Heinz-Josef , Innocenti Federico 
Published: March 2024

PURPOSE The phase III Cancer and Leukemia Group B (CALGB)/SWOG 80405 trial found no difference in overall survival (OS) in patients with metastatic colorectal cancer receiving first-line chemotherapy in combination with either bevacizumab or cetuximab. We investigated the potential prognostic and predictive value of HER2 amplification and gene expression using next-generation sequencing (NGS) and NanoString data. PATIENTS AND METHODS Primary tumor DNA from 559 patients was profiled for HER2 amplification by NGS (FoundationOne CDx). Tumor tissue from 925 patients was tested for NanoString gene expression using an 800-gene panel. OS and progression-free survival (PFS) were the time-to-event end points. RESULTS High HER2 expression (dichotomized at median) was associated with longer PFS (11.6 v 10 months, P = .012) and OS (32 v 25.3 months, P = .033), independent of treatment. An OS benefit for cetuximab versus bevacizumab was observed in the high HER2 expression group ( P = .02), whereas a worse PFS for cetuximab was seen in the low-expression group ( P = .019). When modeled as a continuous variable, increased HER2 expression was associated with longer OS (hazard ratio [HR], 0.83 [95% CI, 0.75 to 0.93]; adjusted P = .0007) and PFS (HR, 0.82 [95% CI, 0.74 to 0.91]; adjusted P = .0002), reaching a plateau effect after the median. In patients with HER2 expression lower than median, treatment with cetuximab was associated with worse PFS (HR, 1.38 [95% CI, 1.12 to 1.71]; adjusted P = .0027) and OS (HR, 1.28 [95% CI, 1.02 to 1.59]; adjusted P = .03) compared with that with bevacizumab. A significant interaction between HER2 expression and the treatment arm was observed for OS ( P intx = .017), PFS ( P intx = .048), and objective response rate ( P intx = .001). CONCLUSION HER2 gene expression was prognostic and predictive in CALGB/SWOG 80405. HER2 tumor expression may inform treatment selection for patients with low HER2 favoring bevacizumab- versus cetuximab-based therapies.
The Landscaped Folds
Authors: Xu Tingting 
Published: March 2024

Abstract
Most of Gong Xian's (1618–1689) long landscape handscrolls were originally structured as accordion albums. This article discusses the morphology and metamorphosis of the accordion folds as a painting format, and rethinks the issues of surface, depth, and depths of Chinese landscape from the perspective of the painter's conception of his work. In the process of landscaping the folds—as opposed to folding the landscapes, Gong Xian subordinated painting to discernable methodologies and sensitives that are inherently related to the folds. The accordion folds were not merely an environmental reference to the representation, but a painter's choice, an authorial impetus and method that effectuated the representation, and an act that realized a work in space. I argue that for Gong Xian, it was not the landscape per se but the painting format that was being represented. Meanwhile, I correlate the issue of format metamorphosis with the increasing ekphrasis in the painting treatises and catalogs compiled in early-modern and modern China to understand image, format, and discourse in a trilateral framework.
Birth Spacing and Parents’ Physical and Mental Health: An Analysis Using Individual and Sibling Fixed Effects
Authors: Barclay Kieron , Kolk Martin , Kravdal Øystein 
Published: March 2024

AbstractAn extensive literature has examined the relationship between birth spacing and subsequent health outcomes for parents, particularly for mothers. However, this research has drawn almost exclusively on observational research designs, and almost all studies have been limited to adjusting for observable factors that could confound the relationship between birth spacing and health outcomes. In this study, we use Norwegian register data to examine the relationship between birth spacing and the number of general practitioner consultations for mothers’ and fathers’ physical and mental health concerns immediately after childbirth (1–5 and 6–11 months after childbirth), in the medium term (5–6 years after childbearing), and in the long term (10–11 years after childbearing). To examine short-term health outcomes, we estimate individual fixed-effects models: we hold constant factors that could influence parents’ birth spacing behavior and their health, comparing health outcomes after different births to the same parent. We apply sibling fixed effects in our analysis of medium- and long-term outcomes, holding constant mothers’ and fathers’ family backgrounds. The results from our analyses that do not apply individual or sibling fixed effects are consistent with much of the previous literature: shorter and longer birth intervals are associated with worse health outcomes than birth intervals of approximately 2–3 years. Estimates from individual fixed-effects models suggest that particularly short intervals have a modest negative effect on maternal mental health in the short term, with more ambiguous evidence that particularly short or long intervals might modestly influence short-, medium-, and long-term physical health outcomes. Overall, these results are consistent with small to negligible effects of birth spacing behavior on (non-pregnancy-related) parental health outcomes.
Identification of genetic suppressors for a BSCL2 lipodystrophy pathogenic variant in Caenorhabditis elegans
Authors: Bai Xiaofei , Smith Harold E. , Golden Andy 
Published: March 2024

ABSTRACT
Seipin (BSCL2), a conserved endoplasmic reticulum protein, plays a critical role in lipid droplet (LD) biogenesis and in regulating LD morphology, pathogenic variants of which are associated with Berardinelli–Seip congenital generalized lipodystrophy type 2 (BSCL2). To model BSCL2 disease, we generated an orthologous BSCL2 variant, seip-1(A185P), in Caenorhabditis elegans. In this study, we conducted an unbiased chemical mutagenesis screen to identify genetic suppressors that restore embryonic viability in the seip-1(A185P) mutant background. A total of five suppressor lines were isolated and recovered from the screen. The defective phenotypes of seip-1(A185P), including embryonic lethality and impaired eggshell formation, were significantly suppressed in each suppressor line. Two of the five suppressor lines also alleviated the enlarged LDs in the oocytes. We then mapped a suppressor candidate gene, lmbr-1, which is an ortholog of human limb development membrane protein 1 (LMBR1). The CRISPR/Cas9 edited lmbr-1 suppressor alleles, lmbr-1(S647F) and lmbr-1(P314L), both significantly suppressed embryonic lethality and defective eggshell formation in the seip-1(A185P) background. The newly identified suppressor lines offer valuable insights into potential genetic interactors and pathways that may regulate seipin in the lipodystrophy model.
Breast cancer prevention behaviour of nurses and midwives - introduction to the discussion
Authors: Charzyńska-Gula Marianna , Rożek Grażyna , Szulich Piotr , Sojda Agnieszka , Tomczyk Bogdan , Zielinska Marta 
Published: March 2024

Introduction Nurses and midwives are a large and therefore very important - for the population effect of many public health activities - group of health care professionals. Breast cancer prevention is one of them.
Aim of the study The aim of the study was to initiate a discussion on the decision-making processes related to the reporting of breast cancer screening by nurses and midwives. The discussion was prompted by the diagnosis of analogous behaviours in a selected group of nurses and midwives working in a selected hospital.
Material and methods A total of 118 nurses and midwives working in one of the Podkarpackie hospitals were studied. A diagnostic survey was used with an author's questionnaire prepared for this study with elements of a knowledge test. The study was conducted in January 2023.
Results In the group of nurses and midwives aged 50 years and older, 10% of nurses and 33.3% of midwives had never performed mammography. Breast ultrasound had never been performed by 25% of nurses and 23.8% of midwives. The reasons for this are varied and stem from both the family experience of the respondents and personal health concerns and beliefs. In the light of the review, it was shown that the participation of nurses and midwives in breast cancer prevention programmes requires a special approach in the design of such programmes and the attitude of nurses and midwives towards participation in oncology screenings demonstrates the need for special support for this group in their decisions.
Conclusions There is an urgent need to use different approaches and models in the preparation of modern decision aids for women recipients of oncology prevention programmes that take into account the trade-offs and preferences of women from both groups - medical women and their clients.
Technical Note—On the Convergence Rate of Stochastic Approximation for Gradient-Based Stochastic Optimization
Authors: Hu Jiaqiao , Fu Michael C. 
Published: March 2024

Finite-Time Performance of Gradient-Based Stochastic Approximation Algorithms Stochastic approximation (SA) algorithms are among the most commonly used methods for addressing stochastic optimization problems. In “Technical Note: On the Convergence Rate of Stochastic Approximation for Gradient-Based Stochastic Optimization,” J. Hu and M. C. Fu provide a new error bound for SA algorithms when applied to a class of problems with convex differentiable structures. The bound allows a detailed characterization of an algorithm’s finite-time performance through directly analyzing the bias and variance of the employed gradient estimator. The main result is then applied to study and compare the efficiency of traditional Kiefer-Wolfowitz algorithms and those based on random direction finite-difference gradient estimators such as simultaneous perturbation SA. The analysis leads to new insights into when it may be advantageous to use such randomized gradient estimates under various problem and algorithm parameter settings.