bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reduce, reuse, recycle: circular economic principles, sustainability and entrepreneurship in developing ecosystems
Authors: Madaan Geetika , Singh Amrinder , Mittal Amit , Shahare Padmakar 
Published: April 2024

PurposeThe circular economy (CE) promotes the recovery of value from waste while also working towards achieving long-term environmentally sustainable goals. The goal of this research is to explore the challenges, opportunities, future scope and green practices that small and medium-sized firms (SMEs) face as they move from the linear economy to the CE.Design/methodology/approachBased on a structured questionnaire, a survey was conducted with representatives from 163 SMEs in India. The data were analysed using co-variance based structural equation modelling technique.FindingsThis research identifies various challenges, including consumer acceptability, worries about awareness, recyclability issues, financial constraints and the absence of a defined management plan for SMEs in adopting the CE. Further, strong management will, innovation, technical up-gradation, training of employees, employee motivation and appropriate guidelines are recognized as essential possibilities for CE implementation.Originality/valueWhile there has been some work on CE, no studies have directly compared these efforts with the goal of shifting from a linear economy to a CE. Given the transient nature of many archives, it is critical that the efforts put into them and the opinions of those who work in them be recorded so that communities can benefit from a shared linear economy in making decisions about their own history.
Modeling and analysis of TiO2 filler's impact on specific wear rate in flax fiber-reinforced epoxy composite under abrasive wear using Taguchi approach
Authors: Prabhu Ravikantha , Mendonca Sharun , Bellairu Pavana Kumara , D'Souza Rudolf , Bhat Thirumaleshwara 
Published: April 2024

PurposeThis study explores how titanium oxide (TiO2) filler influences the specific wear rate (SWR) in flax fiber-reinforced epoxy composites (FFRCs) through a Taguchi approach. It aims to boost abrasive wear resistance by incorporating TiO2 filler, promoting sustainable and eco-friendly materials.Design/methodology/approachThis study fabricates epoxy/flax composites with TiO2 particles (0–8 wt%) using hand layup. Composites were tested for wear following American Society for Testing and Materials (ASTM) G99-05. Statistical analysis used Taguchi design of experiments (DOE), with ANOVA identifying key factors affecting SWR in abrasive sliding conditions.FindingsThe study illuminates how integrating TiO2 filler particles into epoxy/flax composites enhances abrasive wear properties. Statistical analysis of SWR highlights abrasive grit size (grit) as the most influential factor, followed by normal load, wt% of TiO2 and sliding distance. Grit size has the highest effect at 43.78%, and wt% TiO2 filler contributes 15.61% to SWR according to ANOVA. Notably, the Taguchi predictive model closely aligns with experimental results, validating its reliability.Originality/valueThis paper integrates TiO2 filler and flax fibers to form a novel hybrid composite with enhanced tribological properties in epoxy composites. The use of Taguchi DOE and ANOVA offers valuable insights for optimizing control variables, particularly in natural fiber-reinforced composites (NFRCs).
Generative Artificial Intelligence in Business: Towards a Strategic Human Resource Management Framework
Authors: Chowdhury Soumyadeb , Budhwar Pawan , Wood Geoffrey 
Published: April 2024

AbstractAs businesses and society navigate the potentials of generative artificial intelligence (GAI), the integration of these technologies introduces unique challenges and opportunities for human resources, requiring a re‐evaluation of human resource management (HRM) frameworks. The existing frameworks may often fall short of capturing the novel attributes, complexities and impacts of GAI on workforce dynamics and organizational operations. This paper proposes a strategic HRM framework, underpinned by the theory of institutional entrepreneurship for sustainable organizations, for integrating GAI within HRM practices to boost operational efficiency, foster innovation and secure a competitive advantage through responsible practices and workforce development. Central to this framework is the alignment with existing business objectives, seizing opportunities, strategic resource assessment and orchestration, re‐institutionalization, realignment and embracing a culture of continuous learning and adaptation. This approach provides a detailed roadmap for organizations to navigate successfully the complexities of a GAI‐enhanced business environment. Additionally, this paper significantly contributes to the theoretical discourse by bridging the gap between HRM and GAI adoption, the proposed framework accounting for GAI–human capital symbiosis, setting the stage for future research to empirically test its applicability, explore its implications on HRM practices and understand its broader economic and societal consequences through diverse multi‐disciplinary and multi‐level research methodologies.
Impact of Burial Dissolution on the Development of Ultra‐deep Fault‐controlled Carbonate Reservoirs: Insights from High‐temperature and High‐pressure Dissolution Kinetic Simulation
Authors: TAN Xiaolin , ZENG Lianbo , SHE Min , LI Hao , MAO Zhe , SONG Yichen , YAO Yingtao , WANG Junpeng , LÜ Yuzhen 
Published: April 2024

AbstractBurial dissolution is a critical diagenetic process influencing ultra‐deep carbonate reservoir development and preservation. Artificial carbonate samples with different internal structures were prepared, and high‐temperature and high‐pressure dissolution kinetic simulations were conducted. The results demonstrate that the intensity of burial dissolution is controlled by temperature and pressure, while tectonic‐fluid activity influences the development pattern of burial dissolution, ultimately determining the direction of its differential modification. Extensive burial dissolution is likely to occur primarily at relatively shallow depths, significantly influencing reservoir formation, preservation, modification, and adjustment. The development of faults facilitates the maintenance of the intensity of burial dissolution. The maximum intensity of burial dissolution occurs at the tips and overlap zones of faults and intersections of multiple faults. The larger the scale of the faults, the more conducive it is to the development of burial dissolution. Burial dissolution fosters the formation of fault networks characterized by enhanced reservoir capacity and permeability. Burial dissolution controlled by episodic tectonic‐fluid activity is a plausible explanation for forming the Tarim Basin's ultra‐deep fault‐controlled “string‐bead‐like” reservoirs.
GPS tracking reveals koalas Phascolarctos cinereus use mosaics of different forest ages after environmentally regulated timber harvesting
Authors: Law Bradley , Gonsalves Leroy , Slade Chris , Brassil Traecey , Flanagan Cheyne 
Published: April 2024

AbstractAn accurate picture of an animal's home range is fundamental for quantifying habitat quality and response to disturbance. When combined with remote sensing of vegetation attributes, there is potential to assess habitat selection at high resolution. We used a high‐quality GPS‐collaring data set (> 12 500 fixes) from 10 koalas Phascolarctos cinereus and a canopy height model derived from LiDAR in multiple‐use forests harvested for timber 5–10 years previously. Our aim was to assess how individual koalas use the forest mosaic created by timber harvesting by quantifying home ranges and habitat selection of different forest age/height classes created by past harvesting. We found that koalas maintained a stable home range over the average of 7 months of tracking. On average, there was 95% overlap for individuals among seasons, illustrating high site fidelity in the regenerating forest. Also, there were no apparent shifts during the intense drought of spring 2019. Male home ranges (64 ha) were three times the size of females (21 ha). Core areas were considerably smaller, ranging from 15 (male) to 6 ha (female). Three forest age/height classes were defined from LiDAR: (i) harvest – regeneration <14 m, (ii) harvest – retained trees ≥14 m and (iii) harvest – exclusion trees ≥14 m (zones excluded from harvesting for environmental protection). Home ranges covered the mosaic of forest classes and mixed models revealed no selection of forest class based on use versus availability. High site fidelity with no clear selection for forest age/height class (i.e. harvested and non‐harvested patches) confirms that resource quality in the home range remained sufficient for breeding koalas in the post‐harvest landscape. Ongoing monitoring of koalas is required to ensure that environmental protections are effective in maintaining koala populations in the face of additional disturbances from fire and climate change.
Delayed immune‐related adverse events in long‐responders of immunotherapy: a single‐center experience
Authors: Kitano Masatake , Honda Takayuki , Hikita Eri , Masuo Masahiro , Miyazaki Yasunari , Kobayashi Masayoshi 
Published: April 2024

AbstractBackgroundImmune‐checkpoint inhibitors (ICIs) often cause immune‐related adverse events (irAEs). The spectrum of irAEs and their managements has been partially clarified, however the knowledge on time‐course of irAEs is not well understood.MethodsA retrospective study based on the medical record was performed. The study subjects were consisting of patients with various types of solid tumors for whom ICIs (nivolumab, pembrolizumab, durvalumab, atezolizumab, nivolumab plus ipilimumab) were used between April 2016 and October 2021. We focused on irAEs developed more than 1‐year after commencement ICIs (delayed irAE group) and compared with irAEs developed within 1‐year (non‐delayed irAE group) in terms of types and severity of irAEs.ResultsA total of 336 patients were enrolled in the study. Eighty‐eight patients (26.2%) developed irAEs and 248 did not. Most of the patients developing irAEs were treated using PD‐L1/PD‐1 inhibitors. Eighty‐one patients (24.1%) in non‐delayed irAE group and 7 patients (2.1%) in delayed irAE group developed irAEs. The median onset of irAEs in the delayed irAE group was 18.6 months (range: 13.5–24.3). The types of irAEs observed in delayed irAE group were dermatitis (2 cases), pneumonitis (2 cases), nephritis (1 case), arthritis (1 case), and gastritis (1 case). The severity of irAEs was almost mild (≤G2), but one patient (.3%) developed G3 nephritis.ConclusionPD‐L1/PD‐1 inhibitors frequently caused various irAEs but their severities were mostly tolerable. Few patients developed delayed irAE with mild toxities.
The homeostatic effects of the RE‐1 silencing transcription factor on cortical networks are altered under ictogenic conditions in the mouse
Authors: Vitale Carmela , Natali Giulia , Cerullo Maria Sabina , Floss Thomas , Michetti Caterina , Grasselli Giorgio , Benfenati Fabio 
Published: April 2024

AbstractAimThe Repressor Element‐1 Silencing Transcription Factor (REST) is an epigenetic master regulator playing a crucial role in the nervous system. In early developmental stages, REST downregulation promotes neuronal differentiation and the acquisition of the neuronal phenotype. In addition, postnatal fluctuations in REST expression contribute to shaping neuronal networks and maintaining network homeostasis. Here we investigate the role of the early postnatal deletion of neuronal REST in the assembly and strength of excitatory and inhibitory synaptic connections.MethodsWe investigated excitatory and inhibitory synaptic transmission by patch‐clamp recordings in acute neocortical slices in a conditional knockout mouse model (RestGTi) in which Rest was deleted by delivering PHP.eB adeno‐associated viruses encoding CRE recombinase under the control of the human synapsin I promoter in the lateral ventricles of P0‐P1 pups.ResultsWe show that, under physiological conditions, Rest deletion increased the intrinsic excitability of principal cortical neurons in the primary visual cortex and the density and strength of excitatory synaptic connections impinging on them, without affecting inhibitory transmission. Conversely, in the presence of a pathological excitation/inhibition imbalance induced by pentylenetetrazol, Rest deletion prevented the increase in synaptic excitation and decreased seizure severity.ConclusionThe data indicate that REST exerts distinct effects on the excitability of cortical circuits depending on whether it acts under physiological conditions or in the presence of pathologic network hyperexcitability. In the former case, REST preserves a correct excitatory/inhibitory balance in cortical circuits, while in the latter REST loses its homeostatic activity and may become pro‐epileptogenic.
Diagnosis and management of urinary bladder paragangliomas: A Sino‐American‐European retrospective observational study
Authors: Pang Yingxian , Zhang Jing , Jiang Jingjing , Pamporaki Christina , Li Minghao , Bechmann Nicole , Meuter Leah , Wei Yongbao , Huang Haijian , Huang Shenghui , Yu Xunbin , Robledo Mercedes , Soria Miguel J. , Zhong Dewen , Xu Shangyuan , Timmers Henri J. L. M. , Langenhuijsen Johan F. , Chen Xiaofeng , Deng Wanglong , Deutschbein Timo , Remde Hanna , Wang Long , Yao Hanyu , Yan Bin , Berends Annika M. A. , Kerstens Michiel N. , Jiang Yazhuo , Crona Joakim , Xu Ning , Cai Hai , Wen Yanlin , Wang Anguo , Wu Ji , Zhang Zongpin , Ning Jinzhuo , Cheng Fan , Chen Xiang , Wang Jing , Xie Bin , Chen Danlei , Liu Yujun , Liu Longfei , Pacak Karel , Eisenhofer Graeme , Lenders Jacques W. M. 
Published: April 2024

AbstractObjectiveParagangliomas of the urinary bladder (UBPGLs) are rare neuroendocrine tumours and pose a diagnostic and surgical challenge. It remains unclear what factors contribute to a timely presurgical diagnosis. The purpose of this study is to identify factors contributing to missing the diagnosis of UBPGLs before surgery.Design, Patients and MeasurementsA total of 73 patients from 11 centres in China, and 51 patients from 6 centres in Europe and 1 center in the United States were included. Clinical, surgical and genetic data were collected and compared in patients diagnosed before versus after surgery. Logistic regression analysis was used to identify clinical factors associated with initiation of presurgical biochemical testing.ResultsAmong all patients, only 47.6% were diagnosed before surgery. These patients were younger (34.0 vs. 54.0 years, p < .001), had larger tumours (2.9 vs. 1.8 cm, p < .001), and more had a SDHB pathogenic variant (54.7% vs. 11.9%, p < .001) than those diagnosed after surgery. Patients with presurgical diagnosis presented with more micturition spells (39.7% vs. 15.9%, p = .003), hypertension (50.0% vs. 31.7%, p = .041) and catecholamine‐related symptoms (37.9% vs. 17.5%, p = .012). Multivariable logistic analysis revealed that presence of younger age (<35 years, odds ratio [OR] = 6.47, p = .013), micturition spells (OR = 6.79, p = .007), hypertension (OR = 3.98, p = .011), and sweating (OR = 41.72, p = .013) increased the probability of initiating presurgical biochemical testing.ConclusionsMost patients with UBPGL are diagnosed after surgery. Young age, hypertension, micturition spells and sweating are clues in assisting to initiate early biochemical testing and thus may establish a timely presurgical diagnosis.
Impact of age over 70 years in the new allocation system on the outcomes of heart transplantation in the US
Authors: Gemelli Marco , Doulamis Ilias P. , Addonizio Mariangela , Tzani Aspasia , Rempakos Athanasios , Kampaktsis Polydoros , Guariento Alvise , Dunque Ernesto Ruiz , Asleh Rabea , Alvarez Paulino , Briasoulis Alexandros 
Published: April 2024

AbstractBackgroundUnited Network for Organ Sharing (UNOS) allocation criteria changed in 2018 to accommodate the increased prevalence of patients on a ventricular assist device as a bridge to heart transplant and prioritize sicker people in anticipation of a heart graft. We aimed to assess the impact of patient age in the new allocation policy on mortality following heart transplantation. Secondary outcomes included the effect of age ≥70 on post‐transplant events, including stroke, dialysis, pacemaker, and rejection requiring treatment.MethodsThe UNOS Registry was queried to identify patients who underwent heart transplants alone in the US between 2000 and 2021. Patients were divided into groups according to their age (over 70 and under 70 years old).ResultsPatients aged over 70 were more likely to require dialysis during follow‐up, but less likely to experience rejection requiring treatment, compared with patients aged <70. Age ≥70 in the new allocation system was a significant predictor of 1‐year mortality (adjusted HR: 1.41; 95% CI: 1.05–1.91; p = .024), but its effect on 5‐year mortality was not significant after adjusting for potential confounders (adjusted HR: 1.27; 95% CI:.97–1.66; p = .077). Undergoing transplantation under the new allocation policy vs the old allocation policy was not a significant predictor of mortality in patients over 70 years old.ConclusionsAge ≥70 is a significant predictor of 1‐year mortality following heart transplantation, but not at 5 and 10 years; however, the new allocation does not seem to have changed the outcomes for this group of patients.
Clinical practice guidelines on the management of status epilepticus in adults: A systematic review
Authors: Vignatelli Luca , Tontini Valentina , Meletti Stefano , Camerlingo Maria , Mazzoni Stefania , Giovannini Giada , Pasini Elena , Michelucci Roberto , Bisulli Francesca , Tinuper Paolo , Di Vito Lidia 
Published: April 2024

AbstractObjectiveStatus epilepticus (SE) is the second most common neurological emergency in adults. Despite improvements in the management of acute neurological conditions over the last decade, mortality is still durably high. Because a gap has emerged between SE management based on clinical practice guidelines (CPGs) and actual clinical practice, we conducted a systematic review of CPGs, assessing their quality, outlining commonalities and discrepancies in recommendations, and highlighting research gaps.MethodsWe searched the PubMed and EMBASE databases and other gray literature sources (nine among guideline registries, evidence‐based medicine databases, point‐of‐care tools; seven websites of governmental organizations and international neurologic societies) in December 2021 (updated in November 2023). The units of analysis were CPGs that included recommendations on the diagnostic and/or therapeutic management of SE in adults. The quality of the CPGs was assessed using the AGREE II tool.ResultsFifteen CPGs were included. The “Applicability” domain was assigned the lowest median score of 10%. The domains “Stakeholder Involvement”, “Rigor of Development,” and “Editorial Independence” were as well generally underrated. Recommendations on general and diagnostic management and on organizational interventions were fragmented and scattered. Recommendations on pre‐hospital and hospital treatment of early‐onset and refractory SE were broadly agreed, whereas there was less agreement on the treatment model and medications for established SE and super‐refractory SE.SignificanceThe CPGs for the management of SE developed in recent years are flawed by several methodological issues and discrepancies in the coverage of important topics. The gap between CPG‐based management of SE and actual clinical practice may be due in part to the inherent limitations of the CPGs produced so far.
Fungal systems for lignocellulose deconstruction: From enzymatic mechanisms to hydrolysis optimization
Authors: Ren Fengyun , Wu Fan , Wu Xin , Bao Tongtong , Jie Yucheng , Gao Le 
Published: April 2024

AbstractLignocellulosic biomass is an abundant renewable feedstock, but its complex structure of lignocellulose poses barriers to its enzymatic hydrolysis and fermentation. Fungi possess diverse lignocellulolytic enzyme systems that synergistically deconstruct lignocellulose into soluble sugars for fermentation. This review elucidates recent advances in understanding the molecular mechanisms underpinning fungal degradation of lignocellulose. We analyze major enzyme classes tailored by fungi to depolymerize cellulose, hemicellulose, and lignin. Highlighted are the concerted actions and intimate partnerships between these biomass‐degrading enzymes. Current challenges impeding large‐scale implementation of enzymatic hydrolysis are discussed, along with emerging biotechnological opportunities. Advanced pretreatments, high‐throughput enzyme engineering platforms, and machine learning or artificial intelligence‐guided lignocellulolytic enzyme cocktail optimization represent promising ways to improve hydrolytic efficiencies. Elucidating the coordinated interplay and regulation of fungal lignocellulolytic machinery can facilitate optimization of fungal biotechnology platforms. Harnessing the efficiency of fungal biomass deconstruction promises to enhance the development of biorefinery processes for sustainable bioenergy.
DOPPELTE BRECHUNGEN: DAS ‘DURCHS‐FERNGLAS‐SCHAUEN’ IN STIFTERS FRÜHEN ERZÄHLUNGEN
Authors: Schwenke Holger 
Published: April 2024

ABSTRACTThis article explores the extent to which the use of the optical medium of binoculars in Der Condor and Der Hochwald reflects the experience of a paradigmatically new way of seeing. In Der Condor, the refractive power of ‘Durchs‐Fernglas‐Schauen’ is demonstrated by means of a kaleidoscopic fragmentation of the narrative perspective. The portrayal of the hot air balloon ride at the beginning of the story gives tragic evidence of the loss of the beloved as well as of the loss of an overall sense of perception due to the crossing of gazes that are technically mediated. An emancipatory aspect is expressed in that it is a female figure who becomes aware of the ‘transzendentale Obdachlosigkeit’ of modern man. The catastrophe perceived technically from a distance in Der Hochwald raises the question of the fundamental possibilities of representation. The experience of seeing, re‐created here from a narratorical point of view, is a dynamic process of de‐ and restructuring storytelling itself, anticipating moments of non‐representational strategies in the literary modernism of the twentieth century.
HERESY AND ORTHODOXY: A TEXTUAL VARIANT IN THOMAS MANN'S DOKTOR FAUSTUS
Authors: Eagles Peter 
Published: April 2024

ABSTRACTThis article draws upon a textual variant in Thomas Mann's novel Doktor Faustus, and proceeds to investigate the issue which it raises: the role of heresy in the novel, and the question of whether the heretical in art is more accessible or inaccessible than the orthodox. Heresy and its opposite, the orthodox or the ‘pious’, as Mann normally describes it, are categories of religious thought, used by Mann in a transferred sense to convey the spiritual and intellectual dilemma of the modern artist. Given that Adrian Leverkühn is a composer, and that the reader therefore needs to take Mann's description (through the narrator Zeitblom) of his music ‘on trust’, the thesis of this article is that an understanding of the sources within the Christian heretical tradition upon which Leverkühn draws for his compositions is necessary for the reader's understanding of the nature of his music and its relationship to the artistic tradition which it both acknowledges and rejects. The article also posits the decisive influence upon Doktor Faustus of the treatment of heresy in Dostoevsky's major novels. It concludes by considering a further associated textual detail with regard to the question of salvation.