bluuebunny/crossref_metadata_2025_split huggingface dataset:
Protecting Muslim Women against Abuse of Polygamy in Malaysia: Legal Perspective
Authors: Kamaruddin Zaleha , Abdullah Raihanah 
Published: October 2008

AbstractPolygamy remains a controversial issue not only in Malaysia but also in many Muslim countries around the world. From the legal perspective, Muslim men, who choose to enter into polygamous marriages and abuse it, largely due to the absence of eff ective measures taken to curtail the problems bring this about. In Malaysia, these steps include the incorporation of specific provisions controlling the practice of polygamy in the Islamic Family Law Enactments of each state. This move is considered as a step towards formulating better laws to control abuses in the practice of polygamy. This paper discusses the concept behind existing provisions and looks into adequacy of such laws. It also aims at identifying problems and provides suggestions on how women could remain protected within a polygamous set up.
Identifying Climatic Controls on Ring Width: The Timing of Correlations between Tree Rings and NDVI
Authors: Kaufmann R. K. , D’Arrigo R. D. , Paletta L. F. , Tian H. Q. , Jolly W. Matt , Myneni R. B. 
Published: October 2008

Abstract
The authors examine the effects of latitude and life history on the timing of relationships between satellite measures of normalized difference vegetation index (NDVI) and ground-based measures of tree-ring width in forests at mid- and high latitudes in the Northern Hemisphere. Results indicate a correlation between NDVI and tree rings over the entire growing season for all areas analyzed. For sites south of 40°N, a correlation appears in early spring and late fall while a correlation appears during summer months north of 40°N. For conifers, the correlation appears in summer while deciduous trees show the relationship during early spring and late fall. Of these two correlations, the effect of life history seems to dominate the effect of latitude. The timing of these correlations may help clarify the relationship between climate and tree rings and the effect of canopy duration on carbon uptake by trees.
Instability of Surface Quasigeostrophic Vortices
Authors: Carton Xavier 
Published: October 2008

Abstract
The instability of circular vortices is studied numerically in the surface quasigeostrophic (SQG) model, and their evolutions are compared with those of barotropically unstable 2D vortices. The growth rates in the SQG model evidence similarity with their barotropic counterparts for moderate radial gradients of temperature (or of vorticity in the 2D model). For stronger gradients, SQG vortices are more unstable than 2D vortices. The nonlinear, finite-amplitude evolutions of perturbed vortices provide evidence that moderately unstable, elliptically perturbed vortices form tripoles. When they are more unstable, they break into two dipoles. Weakly unstable vortices with triangular perturbations form transient quadrupoles that break; they stabilize only for large gradients of mean temperature. Finally, with square perturbations, pentapoles degenerate into dipoles, at least for the range of mean temperature gradients explored here. The analysis of nonlinear stabilizations reveals that the deformation of the vortex core and the leak of its temperature anomaly to the periphery are essential ingredients to stabilize the perturbation at finite amplitude. In conclusion, SQG vortex instability exhibits considerable similarity to the barotropic instability of 2D vortices.
Generation of Bulk Shear Spikes in Shallow Stratified Tidal Seas
Authors: Burchard Hans , Rippeth Tom P. 
Published: October 2008

Abstract
Recent finescale observations of shear and stratification in temperate shelf sea thermoclines show that they are of marginal stability, suggesting that episodes of enhanced shear could potentially lead to shear instability and diapcynal mixing. The bulk shear between the upper and lower boundary layers in seasonally stratified shelf seas shows remarkable variability on tidal, inertial, and synoptic time scales that has yet to be explained. In this paper observations from the seasonally stratified northern North Sea are presented for a time when the water column has a distinct two-layer structure. Bulk shear estimates, based on ADCP measurements, show a bulk shear vector that rotates in a clockwise direction at the local inertial period, with episodes of bulk shear spikes that have an approximately twice daily period, and occur in bursts that last for several days. To explain this observation, a simple two-layer model based on layer averaging of the one-dimensional momentum equation is developed, forced at the surface by wind stress and damped by (tidally dominated) sea bed friction. The two layers are then linked through an interfacial stress term. The model reproduces the observations, showing that the bulk shear spikes are a result of the alignment of the wind stress, tidal bed stress, and (clockwise rotating) bulk shear vectors. Velocity microstructure measurements are then used to confirm enhanced levels of mixing during a period of bulk shear spikes. A numerical study demonstrates the sensitivity of the spike generation mechanism to the local tidal conditions and the phasing and duration of wind events.
Lidar-Based Estimation of Small-Scale Rainfall: Empirical Evidence
Authors: Lewandowski Piotr A. , Eichinger William E. , Kruger Anton , Krajewski Witold F. 
Published: October 2008

Abstract
A significant scale gap between radar and in situ measurements of rainfall using rain gauges and disdrometers indicates a pressing need for improved knowledge of rainfall variability at the spatial scales below those of today’s operational radar rainfall products, that is, ∼1–4 km. Lidar technology has the potential to fulfill this need, but there has been inconsistency in the literature pertaining to quantitative observations of rain using lidar. Several publications have stated that light scattering properties of raindrops could not be correlated with rain rates, while other papers have demonstrated the existence of such relationships. This note provides empirical evidence in support of the latter claim.
The authors conducted a simple experiment using a near-horizontal-pointing elastic lidar to observe rain in Iowa City, Iowa, in the fall of 2005. The lidar signal was used to estimate rainfall quantities that were subsequently compared with independent estimates of the same quantities obtained from an optical disdrometer that was placed about 370 m from the lidar, ∼10 m below the lidar beam. To perform the conversion from the raw lidar signal, the authors used an optical geometry-based procedure to estimate optical extinction data. A theoretical relationship between extinction coefficients and rain rates was derived based on a theoretical drop size distribution. The parameters of the relationship were found through a best-fit procedure using lidar and disdrometer data. The results show that the lidar-derived rain rates correspond to those obtained from the optical disdrometer with a root-mean-square difference of 55%.
The authors conclude that although a great deal remains to be done to improve the inversion algorithm, lidar measurements of rain are possible and warrant further studies. Lidars deployed in conjunction with disdrometers can provide high spatial (&lt;5 m) and temporal (&lt;1 min disdrometer, ∼1 s lidar) resolution data over a relatively long distance for rainfall measurements (1–2 km in the case of the University of Iowa lidar).
Impact of Data Assimilation on Forecasting Convection over the United Kingdom Using a High-Resolution Version of the Met Office Unified Model
Authors: Dixon Mark , Li Zhihong , Lean Humphrey , Roberts Nigel , Ballard Sue 
Published: October 2008

Abstract
A high-resolution data assimilation system has been implemented and tested within a 4-km grid length version of the Met Office Unified Model (UM). A variational analysis scheme is used to correct larger scales using conventional observation types. The system uses two nudging procedures to assimilate high-resolution information: radar-derived surface precipitation rates are assimilated via latent heat nudging (LHN), while cloud nudging (CN) is used to assimilate moisture fields derived from satellite, radar, and surface observations. The data assimilation scheme was tested on five convection-dominated case studies from the Convective Storm Initiation Project (CSIP). Model skill was assessed statistically using radar-derived surface-precipitation hourly accumulations via a scale-dependent verification scheme. Data assimilation is shown to have a dramatic impact on skill during both the assimilation and subsequent forecast periods on nowcasting time scales. The resulting forecasts are also shown to be much more skillful than those produced using either a 12-km grid length version of the UM with data assimilation in place, or a 4-km grid-length UM version run using a 12-km state as initial conditions. The individual contribution to overall skill attributable to each data-assimilation component is investigated. Up until T + 3 h, LHN has the greatest impact on skill. For later times, VAR, LHN, and CN contribute equally to the skill in predicting the spatial distribution of the heaviest rainfall; while VAR alone accounts for the skill in depicting distributions corresponding to lower accumulation thresholds. The 4-km forecasts tend to overpredict both the intensity and areal coverage of storms. While it is likely that the intensity bias is partially attributable to model error, both VAR and LHN clearly contribute to the overestimation of the areal extent. Future developments that may mitigate this problem are suggested.
Screening for Deep Vein Thrombosis in Asymptomatic High-risk Patients: A Comparison between Digital Photoplethysmography and Venous Ultrasonography
Authors: Sharif-Kashani Babak , Behzadnia Neda , Shahabi Payman , Sadr Makan 
Published: October 2008

Objective To determine the role of digital photoplethysmography in screening asymptomatic patients who are susceptible for developing deep vein thrombosis. Methods Three hundred and thirty-seven limbs in 169 patients who were high risk for development of deep vein thrombosis were assessed by ultrasonography digital photoplethysmography and the results were compared. Results Thirteen limbs were found to have deep vein thrombosis as demonstrated by ultrasonography. All limbs with a venous refilling time greater than 12 seconds had a normal ultrasonography. Compared with ultrasonography and using refilling time less than 12 seconds as the cutoff point, digital photoplethysmography achieved a sensitivity, specificity, positive predictive value, and negative predictive value of 100%, 73.8%, 13.3%, and 100% respectively, for detecting deep vein thrombosis in asymptomatic high-risk patients. Conclusion Digital photoplethysmography is a simple, noninvasive, and highly sensitive test for screening of deep vein thrombosis.
NKp80 defines and stimulates a reactive subset of CD8 T cells
Authors: Kuttruff Sabrina , Koch Sven , Kelp Alexandra , Pawelec Graham , Rammensee Hans-Georg , Steinle Alexander 
Published: October 2008

Abstract
NKp80, an activating homodimeric C-type lectin-like receptor (CTLR), is expressed on essentially all human natural killer (NK) cells and stimulates their cytotoxicity and cytokine release. Recently, we demonstrated that the ligand for NKp80 is the myeloid-specific CTLR activation-induced C-type lectin (AICL), which is encoded in the natural killer gene complex (NKC) adjacent to NKp80. Here, we show that NKp80 also is expressed on a minor fraction of human CD8 T cells that exhibit a high responsiveness and an effector memory phenotype. Gene expression profiling and flow cytometric analyses revealed that this NKp80+ T-cell subset is characterized by the coexpression of other NK receptors and increased levels of cytotoxic effector molecules and adhesion molecules mediating access to sites of inflammation. NKp80 ligation augmented CD3-stimulated degranulation and interferon (IFN)γ secretion by effector memory T cells. Furthermore, engagement of NKp80 by AICL-expressing transfectants or macrophages markedly enhanced CD8 T-cell responses in alloreactive settings. Collectively, our data demonstrate that NKp80 is expressed on a highly responsive subset of effector memory CD8 T cells with an inflammatory NK-like phenotype and promotes T-cell responses toward AICL-expressing cells. Hence, NKp80 may enable effector memory CD8 T cells to interact functionally with cells of myeloid origin at sites of inflammation.
Cell-autonomous and systemic context-dependent functions of iron regulatory protein 2 in mammalian iron metabolism
Authors: Ferring-Appel Dunja , Hentze Matthias W. , Galy Bruno 
Published: October 2008

Abstract
Mice with total and constitutive iron regulatory protein 2 (IRP2) deficiency exhibit microcytosis and altered body iron distribution with duodenal and hepatic iron loading and decreased iron levels in splenic macrophages. To explore cell-autonomous and systemic context-dependent functions of IRP2 and to assess the systemic consequences of local IRP2 deficiency, we applied Cre/Lox technology to specifically ablate IRP2 in enterocytes, hepatocytes, or macrophages, respectively. This study reveals that the hepatic and duodenal manifestations of systemic IRP2 deficiency are largely explained by cell-autonomous functions of IRP2. By contrast, IRP2-deficient macrophages from otherwise IRP2-sufficient mice do not display the abnormalities of macrophages from systemically IRP2-deficient animals, suggesting that these result from IRP2 disruption in other cell type(s). Mice with enterocyte-, hepatocyte-, or macrophage-specific IRP2 deficiency display normal red blood cell and plasma iron parameters, supporting the notion that the microcytosis in IRP2-deficient mice likely reflects an intrinsic defect in hematopoiesis. This work defines the respective roles of IRP2 in the determination of critical body iron parameters such as organ iron loading and erythropoiesis.
Barriers to accessing TB diagnosis for rural-to-urban migrants with chronic cough in Chongqing, China: A mixed methods study
Authors: Long Qian , Li Ying , Wang Yang , Yue Yong , Tang Cheng , Tang Shenglan , Squire S Bertel , Tolhurst Rachel 
Published: October 2008

Abstract

Background
China is facing a significant tuberculosis epidemic among rural-to-urban migrants, which poses a threat to TB control. This study aimed to understand the health seeking behaviour of and health systems responses to migrants and permanent urban residents suffering from chronic cough, in order to identify the factors influencing delays for both groups in receiving a TB diagnosis in urban China.

Methods
Combining a prospective cohort study of adult suspect TB patients and a qualitative study, the Piot model was used to analyze the health seeking behaviour of TB suspects among migrants and permanent urban residents, the factors influencing their decision and the responses by general health providers. Methods included a patient survey, focus group discussions with migrants in the general population, qualitative interviews with migrant and permanent resident TB suspects and TB patients as well as key stakeholders related to TB control and the management of migrants.

Results
Sixty eight percent of migrants delayed for more than two weeks before seeking care for symptoms suggestive of TB, compared to 54% of residents (p < 0.01). When they first decided to seek professional care, migrants were 1.5 times more likely than residents to use less expensive, community-level health services. Only 5% were ultimately referred to a TB dispensary. Major reasons for both patient and provider delay included lack of knowledge and mistrust of the TB control programme, lack of knowledge about TB (patients), and profit-seeking behaviour (providers). In the follow up survey, 61% of the migrants and 41% of the residents who still had symptoms gave up continuing to seek professional care, with a statistically significant difference between the two groups (p < 0.05).

Conclusion
Rural-to-urban migrants are more likely than permanent residents to delay in seeking care for symptoms suggestive of TB in urban Chongqing. 'Patient-' and 'provider-' related factors interact to pose barriers to TB diagnosis for migrants, including: low awareness, and poor knowledge among both the general public and TB suspects about TB as a disease and about the TB control programme; low financial capacity to pay for care and diagnostic tests; and inadequate use of diagnostic tests and referral to TB dispensaries by general health providers.
Can subjective global assessment of nutritional status predict survival in ovarian cancer?
Authors: Gupta Digant , Lammersfeld Carolyn A , Vashi Pankaj G , Dahlk Sadie L , Lis Christopher G 
Published: October 2008

AbstractBackgroundMalnutrition is a significant problem in patients with ovarian cancer. The goal of this study was to investigate the prognostic role of Subjective Global Assessment (SGA) in patients with ovarian cancer treated in an integrative cancer treatment setting.MethodsWe evaluated a case series of 132 ovarian cancer patients treated at Cancer Treatment Centers of America®from Jan 2001 to May 2006. SGA was used to assess nutritional status at baseline. Using SGA, patients were classified as well nourished (SGA A), moderately malnourished (SGA B) or severely malnourished (SGA C). Kaplan Meier method was used to calculate survival. Cox proportional hazard models were constructed to evaluate the prognostic effect of SGA independent of other factors.ResultsOf 132 patients, 24 were newly diagnosed while 108 had received prior treatment. 15 had stage I disease at diagnosis, 8 stage II, 85 stage III and 17 stage IV. The median age at presentation was 54.4 years (range 25.5 – 82.5 years). 66 patients were well-nourished (SGA A), 35 moderately malnourished (SGA B) and 31 severely malnourished (SGA C). Well nourished patients had a median survival of 19.3 months (95% CI: 14.1 to 24.5), moderately malnourished 15.5 months (95% CI: 5.8 to 25.1), and severely malnourished 6.7 months (95% CI: 4.1 to 9.3); the difference being statistically significant (p = 0.0003). Multivariate Cox modeling, after adjusting for stage at diagnosis and prior treatment history found that moderately malnourished and severely malnourished status were associated with a relative risk of 2.1 (95% CI: 1.2 to 3.6, p = 0.008) and 3.4 (95% CI: 1.9 to 5.8, p < 0.001) respectively as compared to well nourished status.ConclusionUnivariate and multivariate survival analyses found that low SGA scores (i.e. well-nourished status) are associated with better survival outcomes. This study lends support to the role of aggressive nutritional intervention in improving patient outcomes in cancer care.
Targeting aspartate aminotransferase in breast cancer
Authors: Thornburg Joshua Marshall , Nelson Kristin K , Clem Brian F , Lane Andrew N , Arumugam Sengodagounder , Simmons Allan , Eaton John W , Telang Sucheta , Chesney Jason 
Published: October 2008

Abstract
Introduction
Glycolysis is increased in breast adenocarcinoma cells relative to adjacent normal cells in order to produce the ATP and anabolic precursors required for survival, growth and invasion. Glycolysis also serves as a key source of the reduced form of cytoplasmic nicotinamide adenine dinucleotide (NADH) necessary for the shuttling of electrons into mitochondria for electron transport. Lactate dehydrogenase (LDH) regulates glycolytic flux by converting pyruvate to lactate and has been found to be highly expressed in breast tumours. Aspartate aminotransferase (AAT) functions in tandem with malate dehydrogenase to transfer electrons from NADH across the inner mitochondrial membrane. Oxamate is an inhibitor of both LDH and AAT, and we hypothesised that oxamate may disrupt the metabolism and growth of breast adenocarcinoma cells.

Methods
We examined the effects of oxamate and the AAT inhibitor amino oxyacetate (AOA) on 13C-glucose utilisation, oxygen consumption, NADH and ATP in MDA-MB-231 cells. We then determined the effects of oxamate and AOA on normal human mammary epithelial cells and MDA-MB-231 breast adenocarcinoma cell proliferation, and on the growth of MDA-MB-231 cells as tumours in athymic BALB/c female mice. We ectopically expressed AAT in MDA-MB-231 cells and examined the consequences on the cytostatic effects of oxamate. Finally, we examined the effect of AAT-specific siRNA transfection on MDA-MB-231 cell proliferation.

Results
We found that oxamate did not attenuate cellular lactate production as predicted by its LDH inhibitory activity, but did have an anti-metabolic effect that was similar to AAT inhibition with AOA. Specifically, we found that oxamate and AOA decreased the flux of 13C-glucose-derived carbons into glutamate and uridine, both products of the mitochondrial tricarboxylic acid cycle, as well as oxygen consumption, a measure of electron transport chain activity. Oxamate and AOA also selectively suppressed the proliferation of MDA-MB-231 cells relative to normal human mammary epithelial cells and decreased the growth of MDA-MB-231 breast tumours in athymic mice. Importantly, we found that ectopic expression of AAT in MDA-MB-231 cells conferred resistance to the anti-proliferative effects of oxamate and that siRNA silencing of AAT decreased MDA-MB-231 cell proliferation.

Conclusions
We conclude that AAT may be a valid molecular target for the development of anti-neoplastic agents.
Bipolar Affective Disorder Following Head Injury
Authors: Bamrah J. S. , Johnson J. 
Published: October 2008

A patient developed distinct episodes of major depressive illness, schizophreniform psychoses and mania as well as focal epilepsy following head injury. Head injury may be directly causative in the development of affective psychoses, in this case secondary bipolar (mixed) disorder.British Journal of Psychiatry (1991), 158, 117–119
Verapamil in Major (Psychotic) Depression
Authors: Jacques Raymond M. , Cox Stephen J. 
Published: October 2008

Dramatic response of major (psychotic) depression to verapamil in an 82–year-old woman suggests that further study of the use of the drug in affective disorders is required, particularly in the light of a possible aetiological role for calcium.British Journal of Psychiatry (1991), 158, 124–125
Depression-Dependent Erotomanic Delusions in a Mentally Handicapped Woman
Authors: Ghaziuddin M. , Tsai L. 
Published: October 2008

Erotomanic delusions occurred in a depressed mentally handicapped woman. Although erotomania is generally classified with paranoid disorders, in people with mental handicap, depression may be the more commonly associated illness.British Journal of Psychiatry (1991), 158, 127–129