bluuebunny/crossref_metadata_2025_split huggingface dataset:
Test for Determining Stimulated Calcitonin Levels
Authors: Леонова Т.А. , Кондратович В.А. , Евтух И.И. , Перхова О.А. , Ананич И.А. , Дыдышко Ю.В. , Шепелькевич А.П. 
Published: March 2024

В статье представлены результаты собственных исследований по разработке и внедрению пробы стимулированного глюконатом кальция уровня кальцитонина. Авторами представлен детальный анализ работ, посвященных проблематике рутинного измерения сывороточного кальцитонина при узловом зобе. Также представлены некоторые технические причины неправильного определения уровня кальцитонина, физиологические и патологические состояния, влияющие на результаты исследования. Приведена методика проведения пробы на стимуляцию сывороточного кальцитонина кальцием с подробным описанием каждого этапа. Сформулированы клинические показания для назначения пробы. Результаты внедрения отражены на конкретных клинических случаях. В качестве обобщения полученных данных приведены возможности ограничения пробы стимулированного глюконатом кальция уровня кальцитонина.
The article presents the results of own research on the development and implementation of a test of calcitonin levels stimulated by calcium gluconate. The authors presented a detailed analysis of works devoted to the problems of routine measurement of serum calcitonin in nodular goiter. Some technical reasons for incorrect determination of calcitonin levels, physiological and pathological conditions that affect the results of the study are also presented. The method for conducting a test for stimulation of serum calcitonin with calcium is presented with a detailed description of each stage. Clinical indications for prescribing the test have been formulated. The implementation results are reflected in specific clinical cases. As a generalization of the data obtained, the test of calcitonin levels stimulated by calcium gluconate the possibilities and limiting are presented.
The Role of Hereditary Factors in the Development of Congenital Hypothyroidism
Authors: Калинина Е.А. , Солнцева А.В. , Зубова Т.В. 
Published: March 2024

Врожденный гипотиреоз является одним из значимых и часто встречающихся заболеваний щитовидной железы у детей. Это этиологически гетерогенная группа тиреопатий врожденного или наследственного генеза, среди которых наследственные формы встречаются в 10–15% случаев. В статье продемонстрированы семейные случаи врожденного гипотиреоза с зобом и без зоба с аутосомно-рецессивным (АР) типом наследования. Внедрение в клиническую практику молекулярно-генетической верификации врожденного гипотиреоза позволит уточнить патогенетический механизм при наследственных формах заболевания, а также достоверно прогнозировать риски повторного рождения в семье ребенка с аналогичной патологией.
Congenital hypothyroidism is one of the most significant and common thyroid diseases in children. This is an etiologically heterogeneous group of thyroid disorders, among which hereditary forms occur in 10–15% of cases. The article demonstrates family cases of congenital hypothyroidism with and without goiter with autosomal recessive inheritance. The introduction of molecular genetic verification of congenital hypothyroidism into clinical practice will make it possible to clarify the pathogenetic mechanism in hereditary forms of the disease, as well as to reliably predict the risks of having a child with a similar pathology.
PENENTUAN KADAR FLAVONOID TOTAL EKSTRAK DAUN RAMBAI LAUT DENGAN VARIASI PELARUT EKSTRAKSI (Sonneratia caseolaris L.)
Authors: Elvansi M. Elvansi , Vifta Rissa Laila 
Published: March 2024

Â ABSTRAKÂ Daun rambai laut (Sonneratia caseolaris L.) diketahuiÂ mempunyai kandungan senyawa flavonoid yang memiliki aktivitas farmakologis. Perbedaan jenis pelarut mempengaruhi kandungan metabolit skunder yang dihasilkan daunÂ rambai laut. Hal ini menunjukan membutuhkan pengendalian mutu kualitas simplisia dan jenis pelarut, sehingga bisa mendapatkan metabolite sekunder yang berkualitas/baik. Tujuan penelitian ini adalah mengetahui nilai rendemen dan kadar flavonoid total ekstrak daun rambai laut menggunakan variasi pelarut yaitu etanol 70%, etil asetat dan N-hexane. Daun rambai laut segar diperoleh dari kota semarang dengan spesifikasi daun yang berwarna hijau tua. Ekstraksi daun rambai laut dilakukan menggunakan metode sokhletasi dan dilanjutkan perhitungan rendemen. Ekstrak daun rambai laut didentifikasi secara kualitatif dan ditentukan kadar flavonoid totalnya. Pengujian flavonoid total secara kuantitatif menggunakan spektrofotometri UV-Vis. Hasil rendemen ekstrak daun rambai laut dengan menggunakan variasi pelarut yaitu ekstrak etanol 70% sebesar 3.4%, ekstrak etil asetat 7.87% dan n-heksan 4.07%. Kadar flavonoid total ekstrak daun rambai laut dengan menggunakan variasi pelarut adalah etanol 70% sebesar 64.05mgQE/g, etil asetat 164.50 mgQE/g dan n-heksan 141.97 mgQE/g. Ekstrak daun rambai laut terdapat pengaruh suatu perbedaan terhadap nilai rendemen dan kadar flavonoid total yang tertinggi menggunakan pelarut etil asetat dibandingkan dengan menggunakan pelarut n-heksan dan etanol 70%.Kata KunciÂ Â Â : Rambai Laut, Flavonoid, Etanol, Etil asetat, n-heksanÂ
PROFIL TERAPI ASMA DI RSI SULTAN AGUNG SEMARANG PERIODE JANUARI â€“ NOVEMBER 2021
Authors: Otavianingsih Dini , Oktianti Dian 
Published: March 2024

Asma merupakan suatu penyakit pada saluran pernafasan yang ditandai dengan peradangan saluran nafas. Asma memerlukan terapi yang cukup kompleks untuk mencegah terjadinya kekambuhan. Tujuan penelitian ini adalah adalah untuk mengetahhi mengenai gambaran terapi asma di RS Islam Sultan Agung.Â Metode penelitian ini adalah penelitian deskriptif dengan metode pengambilan sample secara retroskpektif. Kriteria inklusi sampel adalalah: Pasien usia > 1 tahun sampai 65 tahun yang terdiagnosis penyakit asma, pasien asma yang mendapatkan terapi antiasma, dan yang memiliki kelengkapan data rekam medis. Kriteria eksklusinya adalah pasien hamil dan data rakam medis tidak lengkap. Jumlah sampel sebanyqak 38 buah, kemudian dilakukan tabulasi dan dianalisa secara deskriptif.Â Hasil penelitian: jenis kelamin yang paling banyak adalah perempuan sebanyak 23 orang (60,5%), dengan usia paling banyak adalah usia 19-59 tahun sebanyak 18 orang (47,4%).Â Pemberian obat yang paling banyak adalah secara kombinasi 97,4 % dan kombinasi yang diberikan adalah kombinasi 2 sebanyak 55,2%, penggunaan 3 kombinasi obat sebanyak 42,2% dan golongan obat yaitu golongan agonis Î²2 + kortikosteroid sebanyak 52,6% dan Agonis áµ¦2Â + antikolinergik + kortikosteroid sebanyak 21,1%, Agonis áµ¦2 + kortikosteroid + Metilxantin sebanyak 21,1%.Â Kesimpulan: penggunaan obat asma paling banyak adalah kombinasi 2 obat, yaitu agonis Î²2 + kortikosteroid sebanyak 52,6%Â Kata kunci : Asma, Obat, Terapi, Rumah Sakit
Development of Interactive Learning Multimedia Based on Guided Inquiry to Improve Student Learning Outcomes in Science Content Material Force, Motion and Energy Transfer Class VI SDN Bumi Arum
Authors: Hendra Zul , Kurniati Nia 
Published: March 2024

Class VI science material includes concepts that are fundamental and essential for scientific understanding. However, conventional learning approaches often do not fully utilize students' potential to actively participate in the learning process. Therefore, the development of interactive learning multimedia based on Guided Inquiry is expected to provide a more interesting and effective alternative in teaching these concepts. This study aims to develop and test the effectiveness of Guided Inquiry-Based Interactive Learning Multimedia in increasing students' understanding of Force, Motion, and Energy Transfer material in grade VI science lessons. The method used in writing this journal is based on qualitative writing using a descriptive approach of analysis. The writing technique is based on qualitative data. The results of the field test revealed that the average value obtained increased to 78.79 which was previously 69.68. In addition, based on the results of the study also explained that the use of guided inquiry implemented in science learning media, especially in style material gets better results compared to the use of conventional learning, namely by using textbooks during learning activities. This is proven through a hypothesis test that the value of t table is 2.001 while t count is 2.76. By using guided inquiry models on the topics of interactive multimedia-assisted learning of force, motion, and energy transfer, student learning outcomes can be improved.
Baby Massage is Useful in Stunting Prevention
Authors: Sukamti Sri , Junengsih Junengsih , Aticeh Aticeh , Sriwenda Djuju 
Published: March 2024

Background: Stunting, underweight, and extreme thinness continue to plague Indonesian children's growth; stunting, underweight, and extreme thinness are still common in children under the age of five. One possible countermeasure is providing tactile stimulation (touch) to malnourished babies. Baby massage is a type of tactile stimulation that can help a baby's sense of touch develop.
Purpose: This study aims to determine the effect of baby massage on baby weight gain to prevent stunting in babies below the standard weight curve.
Methods: Quasi-experimental pre-posttest one-group design is used in this study. The study included 21 malnourished babies under two who weighed less than the normal weight curve. Purposive sampling was used to collect the samples. The study was conducted at an independent midwife clinic providing baby massage services. Data was collected using questionnaires and checklist sheets. The dependent t-test is used in data analysis to perform a correlation test.
Results: The results show a significant relationship between baby massage and baby weight gain (P-value 0.001; average weight in the first week was 7714.29 grams, 7909.52 grams in the second week, 8095.24 grams in the fourth week, 8180.95 grams in the fifth week, and 8228.57 grams in the sixth week). The p-value is 0.001, indicating a significant difference between the average increase in body weight from the first to the sixth week.
Conclusion: Weekly massages given consistently and repeatedly to malnourished babies can help them gain weight and prevent stunting. The recommended action is to improve the mother's ability to massage the baby independently to increase the baby's weight
Facilitators of Skilled Birth Attendants’ Utilization in Government and Christian Health Association of Malawi Hospitals: A Cross-Section Study of Lilongwe Rural
Authors: Sumani Woneckilly  Kuseni , Makwero Christopher 
Published: March 2024

Background: Every woman must have access to a Skilled Birth Attendant (SBA) for routine care and management of complications during labour, childbirth, and early postnatal period. SBA utilization has been identified as an essential approach of reducing maternal morbidity and mortality among reproductive age group of 15-49. Malawi as a developing country is also utilizing skilled birth attendants in an effort to reduce maternal death by 70 per 100,000 births. Report of 2020 from Demographic and Health Survey (DHS) on skilled birth attendants (SBA) revealed that Malawi was 89.8% by 2018, while Lilongwe District, the study area, was 67% of SBA utilization against a target of skilled birth attendant utilization of 95% by the year 2022.
Purpose: To evaluate the facilitators of skilled birth attendants’ utilization in government and CHAM hospitals and their relationship to hospital delivery.
Methods: This research used logistic regression test and quantitative cross-sectional approach. Questionnaires were used to collect data from December 2021 to February 2022 in 390 participants. The sampling techniques used were cluster and random sampling.
Results: Based on logistic regression marital status (p=0.001, OR 14.56), pregnancy complication (p=0.000, OR 12.21), and ANC three times (p=0.010, OR 2.11) and four times (p=0.000 OR 0.76) were found to be significantly associated with hospital delivery. On the other hand ANC once (p=0.005, OR -2.33) and twice (P=0.008, OR -1.94) did not significantly influence utilization skilled birth attendants by pregnant mothers
Conclusion: Based on the results, it is concluded that age from 15 to 30 and employment, marital status, education, complication, antenatal clinic, are the facilitators for pregnant mothers to utilize skilled birth attendant. These facilitators might be of importance for policy makers to consider when coming up with programs to increase skilled birth attendants utilization at rural area of Lilongwe District.
PRACTICES OF ENGLISH LANGUAGE TEACHERS IN ASSESSING JUNIOR HIGH SCHOOL STUDENTS’ WRITING PERFORMANCE
Authors: Tabernero Karl Angelo 
Published: March 2024

As English language teachers explore existing writing assessment approaches and strategies, it is, however, inevitable to encounter challenges in the different phases of writing assessment. The challenge is not confined alone to the development of writing assessment tools but more so to the establishment of fair and reliable results for writing performance. It has been argued that the gap between norms and traditions among language schools is one root of such a challenge. One writing assessment practice may work for one setting but not another. Therefore, the present study is intended to discover the writing assessment approaches and strategies employed by junior high school English language teachers in the context and to identify the relevant challenges they encountered in utilizing such writing assessment practices.
To meet the research objective, a qualitative investigation through a narrative inquiry approach was employed. The data were gathered from seven (7) English language teachers in a junior high school in Bataan, Philippines. Self-made, semi-structured interview guides were utilized. The shared narratives from the interviews served as data subjected to thematic analysis.
The research investigation revealed that English language teachers generally utilize scoring rubrics and an analytical approach to assess junior high school students’ writing performance. As a result, they have found challenges in assessing writing performance due to strict adherence to the components of scoring rubrics, time constraints, and the poor writing competencies of students. To address the issues, the study suggests writing assessment programs and training that promote contextualization, ICT integration, and learning autonomy.
English language teachers value the importance of systematic writing assessment practices while also recognizing the roles of emerging practices that will establish not only fairness but also effectiveness that is responsive to the development of the English writing competencies of the students.
Importance of Background Knowledge in Covid-related Internet Memes
Authors: Cighir Anca Irina 
Published: March 2024

2020 was the most challenging year of our lives so far: Covid-19 was our enemy; it was everywhere, on each and every continent, except Antarctica. We were living in a dystopian world and could not see any way out. Besides isolating ourselves and wearing masks everywhere, we had no means to protect ourselves and our loved ones. The only way to stay in touch with our peers and loved ones were our phones and the internet. The internet connected us to people all over the world, we were not alone, we shared feelings and we shared memes. Internet memes were the easiest genre of communication as they expressed so much in such a short time: with only two clicks (copy and paste) we were able to share it with all the people we wanted to.
Our research focuses on the analysis of conceptual metaphors found in Internet memes during the Covid-19 pandemic in order to better understand what kept a lot of the people sane during those days.
PENINGKATAN KUALITAS BONGGOL SINGKONG MELALUI TEKNOLOGI FERMENTASI MENGGUNAKAN Aspergillus niger TERHADAP KANDUNGAN NUTRIEN
Authors: Budi Prasetyo Aris , Baginda Iskandar Moeda Tampoebolon  , Limbang Kustiawan Nuswantara  
Published: March 2024

Faktor terpenting dalam mendukung produktivitas ternak ruminansia adalah ketersediaan pakan yang berkualitas dan tersedia setiap saat. Tujuan penelitian penelitian ini adalah untuk mengkaji pengaruh aras konsentrasi Aspergillus niger dan lama waktu pemeraman terhadap kandungan nutrien bonggol singkong. Penelitian ini didesain menggunakan rancangan acak lengkap pola factorial 3x3 dengan 3 ulangan. Fermentasi menggunakan kapang Aspergillus niger dengan 3 aras konsentrasi (A0: 0%, A1: 2,4% dan A2: 5%) dan lama pemeraman (T0: 0 hari, T1: 2 hari dan T2: 4 hari). Variabel yang diamati adalah kandungan bahan kering, kadar abu, kadar lemak kasar, kadar serat kasar, kadar protein kasar, kadar BETN. Data dianalisis ragam kemudian dilanjutkan dengan uji wilayah ganda Duncan. Hasil penelitian menunjukan terdapat pengaruh interaksi (p<0,05) antar aras dan lama waktu pemeraman yang berbeda terhadap kandungan serat kasar dan protein kasar bonggol singkong yang difermentasi dengan kapang Aspergillus niger. Pada kombinasi perlakuan A2T2 menghasilkan penurunan serat kasar paling tinggi (20,12%), peningkatan protein kasar tertinggi (12,99%). Berdasarkan hasil penelitian dapat disimpulkan bahwa kombinasi perlakuan aras starter dan lama waktu pemeraman meningkatkan protein kasar dan menurunkan serat kasar dengan penggunaan aras starter Aspergillus niger 5% dan lama pemeraman 4 hari.

Kata Kunci: Aspergillus niger, bonggol singkong, kandungan nutrien
PRODUKTIVITAS AYAM KAMPUNG UNGGUL (KUB) DENGAN PEMBERIAN ASAM SITRAT PADA AIR MINUM
Authors: Septinova Dian , Ridwan  , Rudy Sutrisna  , Riyanti  , Madi Hartono  
Published: March 2024

Tujuan penelitian ini adalah untuk mengetahui produktivitas (konsumsi pakam, pertambahan berat tubuh, dan konversi pakan) ayam KUB yang air minumnya diberi asam organik sintentetik (asam sitrat) sebagai feed additif. Rancangan penelitian yang digunakan adalah Rancangan Acak Lengkap (RAL) dengan perlakuan berbagai level asam sitrat di dalam air minum, yaitu 0% asam sitrat (A0), 0,5% asam sitrat (A1), 1,0% asam sitrat (A2), dan 1,5% asam sitrat (A3). Masing-masing perlakuan diulang 5 kali dengan jumlah ayam 10 ekor/ulangan. Penelitian dilakukan sampai umur ayam 8 minggu, sedangkan asam sitrat mulai diberikan saat ayam berumur 1 minggu. Hasil penelitian memperlihatkan bahwa rata-rata konsumsi pakan, pertambahan beratubuh, dan konversi pakan ayam KUB yang air minumnya diberi asam sitrat tidak berbeda nyata (P > 0,05) dengan kontrol. Artinya penambahan asam sitrat dapat diberikan sampai dengan 1,5 % dalam air minum ayam KUB karena tidak memberikan efek buruk. Namun, perlu kajian lebih lanjut tentang level dan teknik pemberian asam sitrat sehingga dapat optimal untuk pertumbuhan ayam KUB.

Kata kunci: Asam sitrat, Ayam KUB, Konsumsi pakan, Pertambahan bobot tubuh, Konversi pakan
SUPLEMENTASI SAKURA BLOCK PLUS PADA RANSUM KOMPLIT BERBASIS LIMBAH SAWIT TERHADAP ASAM LEMAK BERCABANG
Authors: Jarmuji  , Herdiansah Riko 
Published: March 2024

Tujuan penelitian ini untuk mendapatkan level sakura block plus sebagai pakan suplemen pada ransum berbasis limbah sawit dalam mengoptimalkan konsentrasi total branched fatty acid, isobutirat, isovalerat dan valerat pada cairan rumen. Sakura block plus merupakan pakan suplemen hasil modifikasi sakura block dengan menggunakan 6% cacing tanah dan bungkil sawit sebagai pengganti jagung. komposisi ransum berbasis limbah sawit terdiri atas : P0 (ransum berbasis limbah sawit+10% sakura block), P1(ransum berbasis limbah sawit+6% sakura block plus), P2 (ransum berbasis limbah sawit+8% sakura block plus), P3 (ransum berbasis limbah sawit+10% sakura block plus), P4 (ransum berbasis limbah sawit+12% sakura block plus) dan P5 (ransum berbasis limbah sawit+14% sakura block plus). Hasil penelitian menunjukkan suplementasi sakura block plus pada ransum berbasis limbah sawit nyata meningkatkan konsentrasi total branced fatty acid dan isovalerate. Konsentrasi total branched fatty acid dan isovalerat tertinggi dihasilkan pada suplementasi 14% sakura block plus ransum berbasis limbah sawit. Kesimpulan, semakin tinggi suplementasi sakura block plus pada ransum berbasis limbah sawit akan diikuti semakin tinggi juga konsentrasi total branched fatty acid dan isovalerat pada cairan rumen.

Kata kunci: branched fatty acid, isovalerat, ransum berbasis limbah sawit, sakura block plus.
JAVANESE VALUES REFLECTED IN PENGAKUAN PARIYEM NOVEL WRITTEN BY LINUS SURYADI AG
Authors: Priyoto Priyoto , Rahmadiani Anisa 
Published: March 2024

This study aims to determine the values of Javanese society as reflected in Pengakuan Pariyem novel by Linus Suryadi AG. More specifically, this research is aimed to answer two problem questions, namely what the Javanese values are reflected in Pengakuan Pariyem novel.The rationality of the research is to give a better understanding of the Javanese values in Javanese. The method used in this study is a descriptive method, in the form of qualitative, with a sociological approach. In collecting the data, the writer used note-taking technique. The research applied some tools of analysis that developed in the study of literature such as Javanese Values and Cultural Studies. The result of this research brings two contributions namely theoretically and practically. From theoretically, is expected to provide more specific knowledge and information regarding Javanese values. Practically, it may provide helpful reference material for further researchers who are interested in relevant topics. The results of data analysis show that seven kinds of Javanese values are reflected in Pengakuan Pariyem novel: sungkan,halus,grapyak,isin,nrimo,polite, and humble.
ROBERT KEARNS’ OBSESSION IN FIGHTING FOR RECOGNITION IN FLASH OF GENIUS MOVIE
Authors: Hasundungan Jerli , Priyoto Priyoto , Mujani Sahril 
Published: March 2024

The purpose of this study was to analyze know the causes of Robert Kearns the causes of Robert Kearns obsession to obsess in gaining recognition.
This research uses qualitative methods. The object used in this study is a film namely Flash of Genius film. The data collected is obtained from the results of watching the film and sorting out the scenes and dialogues or utterances in the film. The results showed that Robert Kearns experienced some psychological problems which include having mind set all the time, self-doubt, Self-worth, Project delays and abandonment, steering clear of challenges and maintaining a facade at all times
Model Gerak Brown Fraksional Geometrik dalam Peramalan Harga Saham PT Indofood Sukses Makmur Tbk Menggunakan Pemrograman Python
Authors: Putri Nurhadini , Firdaniza Firdaniza , Gusriani Nurul 
Published: March 2024

Peramalan harga saham yang tepat diperlukan oleh para investor. Beberapa metode dapat dilakukan dalam peramalan harga saham, seperti model trend, Autoregressive Integrated Moving Average, Double Moving Average, dan Exponential Smoothing. Selain itu, terdapat pula model yang lebih kompleks, seperti model Gerak Brown Geometrik (GBG) dan model Gerak Brown Fraksional Geometrik (GBFG). Model GBG dan GBFG memiliki beberapa keunggulan, diantaranya dapat meramalkan harga saham dengan periode waktu pendek, kesesuaian model dengan pergerakan harga saham yang selalu bernilai positif dan tidak memerlukan banyak pengujian data. Selain itu, model GBFG juga dapat mengatasi masalah data aktual saham yang sebagian besar tidak saling bebas. Penelitian ini bertujuan melakukan peramalan harga saham PT Indofood Sukses Makmur Tbk (INDF) mengunakan model Gerak Brown Fraksional Geometrik (GBFG). Indeks Hurst pada model GBFG diestimasi menggunakan Rescaled Range (R/S) dengan bantuan pemrograman Python. Hasil dari peramalan pergerakan harga saham PT Indofood Sukses Makmur Tbk (INDF) menggunakan model GBFG memberikan nilai yang sangat akurat berdasarkan nilai MAPE.