bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tumor‐derived components were responsible for suppression of ornithine decarboxylase activity in the rat wounded skin
Authors: Abe Yoshio , Imamura Kiichi , Ogawa Yoshitaka , Tsujinaka Toshimasa , Kobayashi Mitsugu , Yano Masahiko , Kido Yoshihiro , Tanaka Takehiko , Mori Takesada 
Published: February 2007

AbstractTo elucidate the principal cause of delayed wound healing in a tumor‐bearing host, the effect of Yoshida sarcoma‐derived components on dermal wound healing was investigated in rats with the aid of ornithine decarboxylase (ODC) activity and in vivo bromodeoxyuridine (BrdU) labeling index. The ODC activity in the wounded skin decreased 3 and 7 days after intraperitoneal inoculation of Yoshida sarcoma cells (378.0 ± 37.3 on Day 3, 280.0 ± 140.0 on Day 7 vs. 809.3 ± 109.5 pmol/mg protein/hour on Day 0). When administered 24 hours before and immediately after wounding, the crude nuclear component of the tumor cells significantly decreased the ODC activity in the wounded skin as compared with the control (185.9 ± 159.8 vs. 5340 ± 59.1), but the non‐nuclear component was not effective. When nuclear extracts of Yoshida sarcoma cells were intraperitoneally administered immediately after wounding, the 0.15 M or 0.35 M NaCl extract significantly suppressed ODC activity in the wounded skin (233.5 ± 14.5 and 352.3 ± 63.2 pmol/mg protein/hour, respectively) in comparison to the control (445.9 ± 73.6). The BrdU labeling index of epidermal basal cells adjacent to the edge of the wound decreased up to 52% of the control by injection of the 0.15 M extract. It seems that tumor‐derived nuclear components may be responsible for delayed wound healing which is commonly observed in cancer cachexia. © Wiley‐Liss, Inc.
Perioperative allogeneic blood transfusion exacerbates surgical stress‐induced postoperative immunosuppression and has a negative effect on prognosis in patients with gastric cancer
Authors: Maeta Michio , Shimizu Norio , Oka Atsuo , Kondo Akira , Yamashiro Hiroshi , Tsujitani Syunichi , Ikegchi Masahide , Kaibara Nobuaki 
Published: February 2007

AbstractThe immunomodulative effect of perioperative allogeneic blood transfusion on host immunocompetence was studied in 109 patients with gastric cancer at various stages. Mitogen‐induced lymphocyte blastogenesis, lymphocyte surface markers (specific for T, B, CD4, and CD8 populations), and the activity of natural killer (NK) cells were examined before surgery and then 2 and 4 weeks after surgery. The effects on host immunocompetence of transfusion alone, in the absence of any effect of surgical stress, were studied, preoperatively, in nine patients who received preoperative transfusion. Although a tendency towards a decrease in the posttransfusion activity of NK cells was observed, there were no statistically significant differences between pre‐ and posttransfusion levels. Mitogen‐induced blastogenesis and the activity of NK cells were significantly impaired 2 weeks after surgery in transfused patients as compared to those in non‐transfused patients with gastric cancer at stage III and stage IV, and postoperative survival was significantly lower in transfused as compared to nontransfused patients. These results indicate that perioperative allogeneic blood transfusion exacerbates surgical stress‐induced postoperative immunosuppression and has a negative effect on prognosis in patients with gastric cancer. © Wiley‐Liss, Inc.
Lymphokine‐activated killer cell activity of peripheral blood, spleen, regional lymph node, and tumor infiltrating lymphocytes in gastric cancer patients
Authors: Karimine Nobuya , Nanbara Shigeru , Arinaga Shinya , Asoh Tsukasa , Ueo Hiroaki , Akiyoshi Tsuyoshi 
Published: February 2007

AbstractLymphokine‐activated killer (LAK) cell activity of peripheral blood mono‐nuclear cells (PBM), spleen cells (SPC), regional lymph node cells (LNC), and tumor‐infiltrating lymphocytes (TIL), induced by activation with in‐terleukin 2 (IL 2) for 4 days, was evaluated in patients with gastric carcinoma. TIL exhibited the lowest LAK activity and the cytotoxicity of LNC was significantly lower than that of either PBM or SPC. There was no difference between PBM and SPC. Then, there were significant correlations of LAK activity among PBM, SPC, and LNC, whereas poor correlations were observed in the cytotoxicity between TIL and PBM, SPC, or LNC. Phenotypic analysis of each cell population was performed before and after activation with IL 2. Before culture, the cells mediating natural killer (NK) activity such as CD16+, CD56+, and CD57+ cells were few in LNC and TIL. However, CD56+ and CD57+ cells in TIL were increased after culture. Then, CD4+ Leu8+ and CD8+ CD11+ cells, which identify suppressor cell function, were not elevated in LNC or TIL, as compared to that in PBM or SPC. Further, the proportions of OKIa1+ and CD25+ cells expressing T‐cell activation and IL 2 receptor were uniformly increased in all cell populations after culture. These results indicate the differential reactivity of each lymphocyte population to IL 2 and fundamental dysfunction of LNC and, especially TIL, suggesting the specific influence of the local tumor environment on the lymphocyte function in the area in patients with gastric carcinoma. © Wiley‐Liss, Inc.
Wound complications in patients receiving adjuvant chemotherapy after mastectomy and immediate breast reconstruction for breast cancer
Authors: Furey Patricia C. , Macgillivray Dougald C. , Castiglione Charles L. , Allen Lisa 
Published: February 2007

AbstractA retrospective study was done to evaluate the frequency and severity of wound complications in 112 patients with breast cancer who received adjuvant chemotherapy following mastectomy with immediate breast reconstruction. Data on wound complications were available for 120 mastectomies. The rate of complications in 36 mastectomies treated with chemotherapy after mastectomy and immediate reconstruction was compared to that in 84 mastectomies not receiving adjuvant therapy. There were 25 wound complications (20.8%) in the entire group. The rate of wound complications was 27.8% (10 of 36 mastectomies) in the group treated with adjuvant chemotherapy and 17.9% (15 of 84 mastectomies) in the group that did not receive adjuvant therapy (P = 0.13). No patient had a delay in the initiation of adjuvant therapy because of wound complications secondary to immediate reconstruction. Logistic regression analysis found no correlation between age, type of operation, tumor pathology, stage, number of lymph nodes harvested, type of prosthesis or chemotherapy, and wound complications in patients undergoing immediate breast reconstruction after mastectomy. The frequency of wound complications was not increased in patients receiving adjuvant chemotherapy after mastectomy and immediate breast reconstruction. The administration of adjuvant chemotherapy does not need to be delayed in patients who have had immediate breast reconstruction following mastectomy for breast cancer. © Wiley‐Liss, Inc.
Compartment syndrome of the leg secondary to leukemic infiltration: A case report and review of the literature
Authors: Veeragandham Ramesh S. , Paz Isaac Benjamin , Nadeemanee Auayporn 
Published: February 2007

AbstractLeukemic infiltration of muscle is an unusual cause of compartment syndrome. High index of suspicion with early fasciotomy may be the only way to save the leg and prevent life‐threatening complications. Biopsy of the muscle should be done when the etiology of the compartment syndrome is not clear. The probable mechanisms and treatment approaches are discussed. © Wiley‐Liss, Inc.
α‐fetoprotein‐producing rectal cancer: Calculated tumor marker doubling time
Authors: Sato Yoshihiro , Sekine Takeshi , Ohwada Susumu 
Published: February 2007

Abstractα‐fetoprotein (AFP) production by rectal cancer is very rare. In the English literature there are only a few reported cases in which serum AFP level was >1,000 ng/ml.A 43‐year‐old Japanese man with rectal cancer and liver metastases had a high serum AFP level (941 ng/ml) when first evaluated. Three weeks later, the serum AFP level was extremely elevated (7,060 ng/ml). He underwent abdominoperineal excision of the rectum and biopsy of liver metastases. The placement of an intrahepatic‐arterial infusion catheter into the proper hepatic artery via the right gastroepiploic artery was also performed. Immunohistochemically, AFP‐positive cells were identified in both the rectal and liver tumors. Nine days postoperatively, the serum AFP level was 2,000 ng/ml. In spite of intensive chemoimmunotherapy, serum AFP level was increased and 14 weeks after surgery was extremely elevated (267,300 ng/ml). The patient succumbed to cancer 3 months after surgery. To our knowledge, this is the first case of an AFP‐producing rectal cancer in which AFP doubling time could be calculated as 12.8 days. © Wiley‐Liss, Inc.
Lipiodolization for unresectable hepatocellular carcinoma: An analysis of 205 patients using univariate and multivariate analysis
Authors: Urata Keiko , Matsumata Takashi , Kamakura Tatsuro , Hasuo Kanehiro , Sugimachi Keizo 
Published: February 2007

AbstractSince 1982 we have developed and successfully performed lipiodolization on 205 patients with unresectable hepatocellular carcinoma. The 1‐, 2‐, 3‐, 4‐, and 5‐year survival rates were 55.6%, 31.7%, 16.3%, 8.7%, and 2.9%, respectively, while the median survival was 413 days, and 20 patients survived longer than 3 years after the first lipiodolization. Our study demonstrated that the factors for a comparatively good prognosis were as follows: patient older than 50 years, nodular type hepatocellular carcinoma <5 cm in diameter, negative tumor invasion of portal vein, <10 intrahepatic metastases, serum alpha‐fetoprotein level <400 ng/ml, and Okuda stage I. Lipiodolization did not cure hepatocellular carcinoma. It did, however, in this study, achieve a prolongation of the patient's survival. © 1994 Wiley‐Liss, Inc.
Prognostic factors in head and neck soft tissue sarcomas: Analysis of 128 cases
Authors: Kowalski Luiz P. , San Chen I. 
Published: February 2007

AbstractSoft tissue sarcomas make up a heterogenous group of rate malignant tumors originating from mesodermal tissues. Although there have been several improvements in diagnostic methods, staging, and treatment over the past few years, the prognosis of head and neck sarcomas remains worse than those sited at the trunk or extremities. The purpose of this retrospective study was to report the survival results of 128 consecutive patients with soft tissue sarcomas of the head and neck treated from 1953 to 1985. Of the 93 patients submitted to surgical resection, the procedure was considered radical in 67 patients. Of the operated gruop, 46 patients (49.5%) developed recurrence of disease. Thirty‐two patients underwent further treatment (surgery, radiotherapy, or chemotherapy), and 14 patients were salvaged, giving the ultimate result of 65.6% disease control rate in the operated group. The univariate survival analysis showed no statistical difference (P> 0.05) according to age, race, sex, and site or histologic type of the tumor. Radicality of surgery was an important prognostic factor affecting survival (P= 0.0014 for disease‐free interval andP= 0.0183 for overall survival). The multivariate analysis showed that the radicality of surgery and tumor histology were independent prognostic factors affecting recurrence. The same variables and age group were related to the risk of death. Every effort must be made to make an early diagnosis and a radical surgical resection of these tumors must be tried (except for embryonal rhabdomyosarcoma), because it offers the best chance for cure. © 1994 Wiley‐Liss, Inc.
Phylloides tumor of the breast: A report of 14 cases
Authors: Hopkins M. Laura , McGowan Thomas S. , Rawlings Gayle , Liu Fei‐Fei , Fyles Anthony W. , Yeoh J. Lim , Manchul Lee , Levin Wilfred 
Published: February 2007

AbstractThe objective of this retrospective study is to determine the role of radiation therapy in the management of benign phylloides tumors. Fourteen patients with a diagnosis of benign phylloides tumor (PT) and registered at the Princess Margaret Hospital are included in the study. Definitive surgery consisted of either lumpectomy in seven patients or mastectomy in the other seven patients. One patient died of her disease, and the remaining patients had no evidence of disease at last follow‐up (median 38.4 months). Among these 13 patients, 4 had at least one recurrence and the recurrence rate was higher for the group who underwent lumpectomy (43% compared with 28%). One patient was treated by lumpectomy and adjuvant radiation therapy, and had no subsequent recurrence (follow‐up time 35.5 months). The role for radiation therapy in the management of this disease remains unclear. © 1994 Wiley‐Liss, Inc.
Induction chemotherapy in the treatment of patients with carcinoma of the esophagus
Authors: Maipang Tanaphon , Vasinanukorn Prasert , Petpichetchian Chit , Chamroonkul Santi , Geater Alan , Chansawwaang Somchai , Kuapanich Roongroj , Panjapiyakul Chingyiam , Watanaarepornchai Somchai , Punperk Supaporn 
Published: February 2007

AbstractA prospective randomized phase III trial was carried out at Songklanagarind Hospital from August 1988 to December 1990. The objectives of the study were to evaluate the effect of chemotherapy regimen in squamous cell carcinoma of the esophagus and to determine whether induction chemotherapy improves symptom‐free period and survival in these patients compared to surgical treatment alone. Twenty‐four patients were randomized to receive 2 cycles of chemotherapy, cis‐platinum 100 mg/m2 intravenously on day 1, bleomycin 10 mg/m2 loading dose on day 3, followed by 10 mg/m2/day continuous intravenous infusion on days 4 through 7, and vinblastine 3 mg/m2 given intravenously on days 1, 8, 15, 22. The cycle was repeated on day 29. Fifteen patients completed 2 courses of chemotherapy and among these, 2 patients had a complete clinical response (13%), 6 (40%) had a partial response, and 7 patients (47%) had no response. Four patients died during chemotherapy treatment. Grade 3 hematologic toxicity (ECOG criteria) was observed in 47% (7/15) of patients. Twenty‐two patients were randomized to conventional treatment (surgery alone). Median survival time was 17 months in both groups. However, early survival appeared to be better in the control group. Kaplan‐Meier survivals at 6 months were 69% and 89% and at 3 years were 31% and 36% for the induction chemotherapy group and control group, respectively. The survival time differences were not statistically significant (P = 0.186). These findings demonstrate that although this chemotherapy regimen had some effect on squamous cell carcinoma of esophagus, it did not improve survival. On the contrary, survival seems to be better in the control group. The 6‐month survival discrepancy between both groups might be due to the poor nutritional status of our patients, who may better tolerate smaller dosages of chemotherapy. © 1994 Wiley‐Liss, Inc.
Triple approach in the diagnosis of dominant breast masses: Combined physical examination, mammography, and fine‐needle aspiration
Authors: Kaufman Zvi , Shpitz Baruch , Shapiro Myra , Rona Ronny , Lew Sylvia , Dinbar Alex 
Published: February 2007

AbstractIn an attempt to reduce the number of breast biopsies done for benign breast disease in patients with breast lumps, we evaluated prospectively the sensitivity and specificity of the combination of three diagnostic modalities: clinical examination, mammography, and fine‐needle aspiration cytologic examination (FNA). A total of 234 patients with a breast mass had a physical examination, a mammogram, and FNA, and were listed as malignant/suspicious or benign. All patients underwent a subsequent biopsy: 110 were found to have breast cancer, and 124 had a benign lesion. The sensitivity and specificity of the individual tests were as follows: 89% and 73%, respectively, for mammographic examination; 93% and 97% for FNA cytologic examination; and 89% and 60% for physical examination. For the combined triad of tests, the sensitivity was 100% and specificity 57%. All patients who had breast cancer had positive findings for malignancy in one or more of the diagnostic tests, i. e., 100% sensitively. All patients who had negative findings for malignancy in all three diagnostic tests had benign lesions, i. e., a negative predictive value of 100%. We conclude that breast masses can be diagnosed with a high degree of accuracy by combined physical, mammographic, and fine‐needle aspiration cytologic examination. Patients in whom physical examination, mammography, and FNA were negative for malignancy can be safely observed, obviating the need for an open biopsy. © 1994 Wiley‐Liss, Inc.
Risk analysis of carcinogenesis in the remnant stomach with measurement of ornithine decarboxylase activity
Authors: Kitao Yoshitaka , Yamane Tetsuro , Kikuoka Norikazu , Matsumoto Hirohiko , Oya Kazuhiko , Inagake Masao , Takahashi Toshio 
Published: February 2007

AbstractGastric ornithine decarboxylase (ODC) activity was measured as a biomarker of tumor‐promoting activity in the remnant stomach of rats and humans. Gastrectomy of Wistar rats utilizing the Billroth I method caused a significantly high induction of ODC, and use of the Billroth II method caused a significantly higher induction of ODC than the Billroth I method. In humans, ODC activity of remnant gastric cancer tissue, normal‐appearing mucosa of remnant gastric cancer patient, and remnant gastric mucosa without cancer after the Billroth II method were significantly higher than that of normal gastric mucosa without gastrectomy. ODC activity of remnant gastric mucosa without cancer after the Billroth II method was significantly higher than that after the Billroth I method. Risk of carcinogenesis was high in the remnant stomach, especially after the Billroth II method. © 1994 Wiley‐Liss, Inc.
Dose intensity of mitomycin C in adjuvant cancer chemotherapy for patients with gastric cancer
Authors: Kubota Tetsuro , Kumai Koichiro , Kitajima Masaki , Abe Osahiko , Fujisaki Masato , Yamada Yoshinori , Ushijima Yasuhide , Ishibiki Kyuya 
Published: February 2007

AbstractUsing a cohort of macroscopic curative resections of gastric cancer at stages II, III, and IV, a randomized controlled trial was performed to elucidate the dose efficacy of intensive adjuvant cancer chemotherapy with mitomycin C. Between June 1983 and December 1986, 336 patients with gastric cancer from 31 institutes were enrolled in the study. The cohort was stratified randomly by the telephone method into two arms. Group A received 20 mg and 10 mg of mitomycin C per body intravenously (IV) on postoperative days 0 and 1, respectively, and then tegafur at 600 mg/body daily perorally (PO) from postoperative week 2 for 1 year. Group B also received 0.2 mg of mitomycin C per kg IV at 3, 6, 9, and 12 months after surgery. The background factors in groups A and B were essentially identical, and the adverse effects were tolerable in both groups. The total administered doses of mitomycin C were significantly higher in group B than in group A, according to the protocol. Although no significant differences were observed in the actuarial overall survival rates between groups A and B at stages II, III, and IV, favorable survival was observed in group B, which received histologically absolute curative resection. This dose‐intensive adjuvant cancer chemotherapy would be useful for gastric cancer patients treated by histologically curative surgery. © 1994 Wiley‐Liss, Inc.
Prognostic factors of colorectal cancer: K‐ras mutation, overexpression of the p53 protein, and cell proliferative activity
Authors: Tanaka Matsuhei , Omura Kenji , Watanabe Yoh , Oda Yoshio , Nakanishi Isao 
Published: February 2007

AbstractBetween June 1990 and April 1991,62 colorectal tumors were assessed in a prospective fashion on the basis of various tumor characteristics. Parameters included K‐ras mutation, overexpression of the p53 protein, and proliferating cell nuclear cell antigen, as well as standard histopathologic examination. A multivariate analysis showed that K‐ras mutation correlated with vascular invasion (P< 0.01) and hematogenous metastasis (P< 0.01). With regard to survival time, multivariate analyses using the Cox proportional hazard model suggested that status of lymph node metastasis (P<0.01, relative risk [rr]=7.27), TNM stage (P< 0.05, rr=5.37), lymphatic invasion (P< 0.05, rr=4.48), and K‐ras mutation (P< 0.06, rr=3.69) are the most independent prognostic factors. We compared the prognostic value of the molecular assays and standard TNM prognostic factors by multivariate analysts. © 1994 Wiley‐Liss, inc.
Estrogen and progesterone receptor concordance between primary and recurrent breast cancer
Authors: Li Benjamin D. L. , Byskosh A. , Duda Rosemary B. , Molteni A. 
Published: February 2007

AbstractEstrogen and progesterone receptor status in breast cancer can determine therapeutic options and may provide prognostic information. The purpose of this study is to compare the concordance of the primary breast cancer steroid hormone receptor status to that of the recurrent breast cancer and to determine whether the type of second lesion (local recurrence, second primary, or metatastic lesion) and adjuvant therapy received changed the receptor concordance. The records of eighty‐three patients with estrogen receptor (ER) analysis available for primary (p) and recurrent (r) breast cancer for 1976‐1990 were reviewed. In addition, 32 of these patients also had available progesterone receptor (PR) values for primary and recurrent breast cancers. Statistical evaluation was performed by chi‐square, Student's r‐test, and Wilcoxon signed‐rank test. ER concordance (primary/ recurrent, p/r) was identified in 59/83 (71 %) patients; PR concordance was identified in 18/32 (56%) patients. Whether the second lesion was a local recurrence, second primary, or a metastatic lesion did not affect ER concordance or PR concordance. Adjuvant chemotherapy, hormonal therapy, or radiation therapy, either alone or in combination, did not affect ER or PR concordance. The disease‐free survival (DFS) for patients with ER (p+)/(r‐) (primary receptor positive/recurrent receptor negative) was significantly shorter than those with ER (p‐)/(r+)(27.6 ± 7.4 months versus 50.6 ± 7.6 mo, P=0.04). The DFS for PR (p+)/(r‐) patients was 28.8 ± 7.9 months compared to the DFS of 46.8 ± 11.8 months for PR (p‐)/(r+) patients (P=NS). A significantly shorter DFS for ER (p+)/ (r‐) patients compared to ER (p‐)/(r+) patients and a trend towards a shorter DFS for PR (p+)/(r‐) patients compared to PR (p‐)/(r+) patients may reflect a loss of hormonal regulation or an increase in cancer aggressiveness. © 1994 Wiley‐Liss, Inc.