bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGARUH KOMPENSASI DAN MOTIVASI TERHADAP KINERJA KARYAWAN DENGAN KEPUASAN KERJA SEBAGAI VARIABEL INTERVENING
Authors: Hidayat Akbar 
Published: March 2024

Tujuan penelitian ini adalah: Untuk menguji Kompensasi terhadap kinerja karyawan, Motivasi terhadap Kinerja karyawan, Kepuasan kerja terhadap Kinerja Karyawan, Kompensasi terhadap Kepuasan Kerja, Motivasi terhadap Kepuasan kerjaÂ dan Kompensasi terhadap Kinerja Karyawan dengan Kepuasan Kerja sebagai variabel mediasi, Motivasi terhadap Kinerja karyawan dengan Kepuasan Kerja sebeagai variabel mediasi. Teknik analisis data yang digunakan adalah Structural Equation Modeling (SEM) dengan menggunakan WarpPls 5.0. Sampel yang digunakan dalam penelitian ini adalah karyawan di Rumah Sakit Umum Universitas Muhammadiyah Malang dengan total sebanyak 218 karyawan. Hasil penelitian menunjukkan bahwa secara umum adanya pengaruh yang terjadi antara Kompensasi terhadap kinerja karyawan, Motivasi terhadap Kinerja karyawan, Kepuasan kerja terhadap kinerja karyawan, Kompensasi terhadap Kepuasan Kerja, Motivasi Terhadap Kepuasan Kerja, Namun Kepuasan Kerja tidak mampu memediasi pengaruh yang terjadi antara Kompensasi terhadap kinerja karyawan, serta Kepuasan Kerja tidak mampu memediasi pengaruh yang terjadi antara Motivasi terhadap Kinerja karyawan.Kata Kunci:Â Kompensasi, Motivasi, Kepuasan Kerja dan Kinerja Karyawan.Â Â Â Â Â Â Â Â Â Â Â Â The objectives of this study are: To examine compensation for employee performance, motivation for employee performance, job satisfaction with employee performance, compensation for job satisfaction, motivation for job satisfaction and compensation for employee performance with job satisfaction as a mediating variable, motivation for employee performance with satisfaction. Work as a mediating variable. The data analysis technique used is Structural Equation Modeling (SEM) using WarpPls 5.0.The sample used in this study were employees at the General Hospital of the University of Muhammadiyah Malang with a total of 218 employees. The results show that in general there is an influence between compensation on employee performance, motivation on employee performance, job satisfaction on employee performance, compensation for job satisfaction, motivation for job satisfaction, but job satisfaction is not able to mediate the effect that occurs between compensation on performance. employees, and job satisfaction are not able to mediate the effect that occurs between motivation on employee performanceKeywords:Â Compensation, Motivation, Job Satisfaction and Employee Performance
Signatures of disease outcome severity in the intestinal fungal and bacterial microbiome of COVID-19 patients
Authors: Rizzello Fernando , Viciani Elisa , Gionchetti Paolo , Filippone Eleonora , Imbesi Veronica , Melotti Laura , Dussias Nikolas Konstantine , Salice Marco , Santacroce Barbara , Padella Antonella , Velichevskaya Alena , Marcante Andrea , Castagnetti Andrea 
Published: March 2024

BackgroundCOVID-19, whose causative pathogen is the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), was declared a pandemic in March 2020. The gastrointestinal tract is one of the targets of this virus, and mounting evidence suggests that gastrointestinal symptoms may contribute to disease severity. The gut–lung axis is involved in the immune response to SARS-CoV-2; therefore, we investigated whether COVID-19 patients’ bacterial and fungal gut microbiome composition was linked to disease clinical outcome.MethodsIn May 2020, we collected stool samples and patient records from 24 hospitalized patients with laboratory-confirmed SARS-CoV-2 infection. Fungal and bacterial gut microbiome was characterized by amplicon sequencing on the MiSeq, Illumina’s integrated next generation sequencing instrument. A cohort of 201 age- and sex-matched healthy volunteers from the project PRJNA661289 was used as a control group for the bacterial gut microbiota analysis.ResultsWe observed that female COVID-19 patients had a lower gut bacterial microbiota richness than male patients, which was consistent with a different latency in hospital admittance time between the two groups. Both sexes in the COVID-19 patient study group displayed multiple positive associations with opportunistic bacterial pathogens such as Enterococcus, Streptococcus, and Actinomyces. Of note, the Candida genus dominated the gut mycobiota of COVID-19 patients, and adult patients showed a higher intestinal fungal diversity than elderly patients. We found that Saccharomycetales unassigned fungal genera were positively associated with bacterial short-chain fatty acid (SCFA) producers and negatively associated with the proinflammatory genus Bilophila in COVID-19 patients, and we observed that none of the patients who harbored it were admitted to the high-intensity unit.ConclusionsCOVID-19 was associated with opportunistic bacterial pathogens, and Candida was the dominant fungal taxon in the intestine. Together, we found an association between commensal SCFA-producers and a fungal genus that was present in the intestines of patients who did not experience the most severe outcome of the disease. We believe that this taxon could have played a role in the disease outcome, and that further studies should be conducted to understand the role of fungi in gastrointestinal and health protection.
Study on overburden failure characteristics and ground pressure behavior in shallow coal seam mining underneath the gully
Authors: Zhang Jie , Wang Li , Yang Tao , Gao Shoushi , He Yifeng , Wu Jianjun 
Published: March 2024

Introduction: This study focuses on investigating the characteristics of overburden failure and ground pressure behavior in shallow coal seam mining beneath a gully. The research is conducted at the 135201 working face of Shaliang Coal Mine in the Shenfu Mining Area.Methods: The study employs physical similarity simulation tests, theoretical analysis, and field measurements to analyze the ground pressure and overburden failure characteristics at the working face.Results: The research findings indicate that the ground pressure is stronger in the uphill section compared to the gully bottom and downhill sections. The weighting interval in the uphill section is the smallest. A mechanical analysis model for the failure structure of the key stratum in the uphill section is established based on monitored ground pressure data and physical simulation test results. A calculation formula for the weighting interval in the uphill section is derived. The relationship between the caving interval, the thickness of the key stratum in the uphill section, and the gully slope is also analyzed. The on-site measurements align well with the theoretical results.Discussion: The study proposes a prediction method for ground pressure and suggests hazard prevention and control measures for shallow coal seam mining beneath a gully based on the research findings.
Artificial intelligence literacy in sustainable development: A learning experiment in higher education
Authors: Alamäki Ari , Nyberg Crister , Kimberley Anna , Salonen Arto O. 
Published: March 2024

IntroductionThe purpose of this empirical research was to map the capabilities and perceptions of undergraduate business administration students about artificial intelligence (AI) and its potential to answer questions related to sustainable transition in society, and to obtain information about the suitable pedagogical solution to increase the knowledge and understanding related to these themes.MethodsThe data was gathered among higher education (HE) students in a workshop that consisted of introductory lecture, answering surveys, questionnaire, group discussions, and reflective narratives on the relationship and possibilities of AI and sustainable development. In data analysis an abductive qualitative research methodology was adopted.ResultsThrough abduction new insights were obtained and new knowledge was created new knowledge regarding AI literacy in the context of sustainable development. This brought new knowledge in the context of HE studies. The taxonomy of AI literacy in sustainable development created a new reference framework for learning tasks, and course planning in HE. The findings showed that the students had difficulties solving the actual problem because they lacked knowledge and understanding of the basics of AI and sustainable development. However, in groups where one person had a deeper understanding of the concepts, the whole group began to understand the task and work on both meta-level ethical questions and practical examples.DiscussionThe assistance of AI potentially creates opportunities for developing solutions supporting sustainable development. However, utilizing this potential requires AI literacy. In this task HE plays a significant role. This study contributes to the pedagogical approach where AI and sustainable development are integrated in HE curricula.
Causal relationship between PCSK9 inhibitor and primary glomerular disease: a drug target Mendelian randomization study
Authors: Duan Hangyu , Shi Yue , Zhang Qi , Shi Xiujie , Zhang Yifan , Liu Jing , Zhang Yu 
Published: March 2024

BackgroundSuccessive observational studies have highlighted low-density lipoprotein cholesterol (LDL-C) as a standalone risk factor for the progression of chronic kidney disease (CKD) to end-stage renal disease. Lowering LDL-C levels significantly reduces the incidence of atherosclerotic events in patients with progressive CKD. Recent research indicates that proprotein convertase subtilisin kexin 9 (PCSK9) inhibitors not only effectively lower LDL-C levels in CKD patients but also exhibit therapeutic potential for autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, and ulcerative colitis. However, the role of PCSK9 inhibitors (PCSK9i) in treating CKD beyond lowering LDL-C levels remains uncertain. Therefore, this study employs drug-targeted Mendelian randomization (MR) to investigate the causal impact of PCSK9i on primary glomerular diseases such as IgA nephropathy (IgAN), membranous nephropathy (MN), and nephrotic syndrome (NS).MethodsSingle-nucleotide polymorphisms (SNPs) linked to LDL-C were sourced from the Global Lipids Genetics Consortium genome-wide association study (GWAS). Genes situated in proximity to 3-Hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), and PCSK9 served as proxies for therapeutic inhibition of these targets. The causal link between PCSK9i and the risk of primary glomerular disorders was discovered using drug-target MR studies. The HMGCR inhibitor, a drug target of statins, was utilized for comparative analysis with PCSK9i. Primary outcomes included the risk assessment for IgAN, MN, and NS, using the risk of coronary heart disease as a positive control.ResultsThe inhibition of PCSK9, as proxied genetically, was found to significantly reduce the risk of IgAN [odds ratio, OR (95% confidence interval, CI) = 0.05 (−1.82 to 1.93), p = 2.10 × 10−3]. Conversely, this inhibition was associated with an increased risk of NS [OR (95% CI) = 1.78 (1.34–2.22), p = 0.01]. Similarly, HMGCR inhibitors (HMGCRi) demonstrated a potential reduction in the risk of IgAN [OR (95%CI) = 0.0032 (−3.58 to 3.59), p = 1.60 × 10−3).ConclusionsPCSK9i markedly decreased the risk of IgAN, suggesting a potential mechanism beyond their primary effect on LDL-C. However, these inhibitors were also associated with an increased risk of NS. On the other hand, HMGCRi appears to serve as a protective factor against IgAN. Conversely, PCSK9i may pose a risk factor for NS, suggesting the necessity for cautious application and further research into their impacts on various glomerular diseases.
Prevalence of concomitant rheumatologic diseases and autoantibody specificities among racial and ethnic groups in SLE patients
Authors: Denvir Brendan , Carlucci Philip M. , Corbitt Kelly , Buyon Jill P. , Belmont H. Michael , Gold Heather T. , Salmon Jane E. , Askanase Anca , Bathon Joan M. , Geraldino-Pardilla Laura , Ali Yousaf , Ginzler Ellen M. , Putterman Chaim , Gordon Caroline , Barbour Kamil E. , Helmick Charles G. , Parton Hilary , Izmirly Peter M. 
Published: March 2024

ObjectiveLeveraging the Manhattan Lupus Surveillance Program (MLSP), a population-based registry of cases of systemic lupus erythematosus (SLE) and related diseases, we investigated the proportion of SLE with concomitant rheumatic diseases, including Sjögren’s disease (SjD), antiphospholipid syndrome (APLS), and fibromyalgia (FM), as well as the prevalence of autoantibodies in SLE by sex and race/ethnicity.MethodsPrevalent SLE cases fulfilled one of three sets of classification criteria. Additional rheumatic diseases were defined using modified criteria based on data available in the MLSP: SjD (anti-SSA/Ro positive and evidence of keratoconjunctivitis sicca and/or xerostomia), APLS (antiphospholipid antibody positive and evidence of a blood clot), and FM (diagnosis in the chart).Results1,342 patients fulfilled SLE classification criteria. Of these, SjD was identified in 147 (11.0%, 95% CI 9.2–12.7%) patients with women and non-Latino Asian patients being the most highly represented. APLS was diagnosed in 119 (8.9%, 95% CI 7.3–10.5%) patients with the highest frequency in Latino patients. FM was present in 120 (8.9%, 95% CI 7.3–10.5) patients with non-Latino White and Latino patients having the highest frequency. Anti-dsDNA antibodies were most prevalent in non-Latino Asian, Black, and Latino patients while anti-Sm antibodies showed the highest proportion in non-Latino Black and Asian patients. Anti-SSA/Ro and anti-SSB/La antibodies were most prevalent in non-Latino Asian patients and least prevalent in non-Latino White patients. Men were more likely to be anti-Sm positive.ConclusionData from the MLSP revealed differences among patients classified as SLE in the prevalence of concomitant rheumatic diseases and autoantibody profiles by sex and race/ethnicity underscoring comorbidities associated with SLE.
A protective effect of inflammatory bowel disease on the severity of sclerosing cholangitis
Authors: Stumme Friederike , Steffens Niklas , Steglich Babett , Mathies Franziska , Nawrocki Mikolaj , Sabihi Morsal , Soukou-Wargalla Shiwa , Göke Emilia , Kempski Jan , Fründt Thorben , Weidemann Sören , Schramm Christoph , Gagliani Nicola , Huber Samuel , Bedke Tanja 
Published: March 2024

BackgroundPrimary sclerosing cholangitis (PSC) is a chronic liver disease marked by inflammation of the bile ducts and results in the development of strictures and fibrosis. A robust clinical correlation exists between PSC and inflammatory bowel disease (IBD). At present, published data are controversial, and it is yet unclear whether IBD drives or attenuates PSC.MethodsMdr2-deficient mice or DDC-fed mice were used as experimental models for sclerosing cholangitis. Additionally, colitis was induced in mice with experimental sclerosing cholangitis, either through infection with Citrobacter rodentium or by feeding with DSS. Lastly, fibrosis levels were determined through FibroScan analysis in people with PSC and PSC-IBD.ResultsUsing two distinct experimental models of colitis and two models of sclerosing cholangitis, we found that colitis does not aggravate liver pathology, but rather reduces liver inflammation and liver fibrosis. Likewise, people with PSC-IBD have decreased liver fibrosis compared to those with PSC alone.ConclusionsWe found evidence that intestinal inflammation attenuates liver pathology. This study serves as a basis for further research on the pathogenesis of PSC and PSC-IBD, as well as the molecular mechanism responsible for the protective effect of IBD on PSC development. This study could lead to the discovery of novel therapeutic targets for PSC.
Exploring potential biomarkers and therapeutic targets in inflammatory bowel disease: insights from a mega-analysis approach
Authors: Stemmer Edia , Zahavi Tamar , Kellerman Maoz , Sinberger Liat Anabel , Shrem Guy , Salmon‐Divon Mali 
Published: March 2024

BackgroundUnderstanding the molecular pathogenesis of inflammatory bowel disease (IBD) has led to the discovery of new therapeutic targets that are more specific and effective. Our aim was to explore the molecular pathways and genes involved in IBD pathogenesis and to identify new therapeutic targets and novel biomarkers that can aid in the diagnosis of the disease.MethodsTo obtain the largest possible number of samples and analyze them comprehensively, we used a mega-analysis approach. This involved reprocessing raw data from multiple studies and analyzing them using bioinformatic and machine learning techniques.ResultsWe analyzed a total of 697 intestinal biopsies of Ulcerative Colitis (n = 386), Crohn’s disease (n = 183) and non-IBD controls (n = 128). A machine learning analysis detected 34 genes whose collective expression effectively distinguishes inflamed biopsies of IBD patients from non-IBD control samples. Most of these genes were upregulated in IBD. Notably, among these genes, three novel lncRNAs have emerged as potential contributors to IBD development: ENSG00000285744, ENSG00000287626, and MIR4435-2HG. Furthermore, by examining the expression of 29 genes, among the 34, in blood samples from IBD patients, we detected a significant upregulation of 12 genes (p-value &lt; 0.01), underscoring their potential utility as non-invasive diagnostic biomarkers. Finally, by utilizing the CMap library, we discovered potential compounds that should be explored in future studies for their therapeutic efficacy in IBD treatment.ConclusionOur findings contribute to the understanding of IBD pathogenesis, suggest novel biomarkers for IBD diagnosis and offer new prospects for therapeutic intervention.
The protective effect of tumor necrosis factor-alpha inhibitors in COVID-19 in patients with inflammatory rheumatic diseases compared to the general population—A comparison of two German registries
Authors: Hasseli Rebecca , Hanses Frank , Stecher Melanie , Specker Christof , Weise Tobias , Borgmann Stefan , Hasselberger Martina , Hertenstein Bernd , Hower Martin , Hoyer Bimba F. , Koll Carolin , Krause Andreas , von Lilienfeld-Toal Marie , Lorenz Hanns-Martin , Merle Uta , Nunes de Miranda Susana M. , Pletz Mathias W. , Regierer Anne C. , Richter Jutta G. , Rieg Siegbert , Roemmele Christoph , Ruethrich Maria M. , Schmeiser Tim , Schulze-Koops Hendrik , Strangfeld Anja , Vehreschild Maria J.G.T. , Voit Florian , Voll Reinhard E. , Vehreschild Jörg Janne , Müller-Ladner Ulf , Pfeil Alexander 
Published: March 2024

ObjectivesTo investigate, whether inflammatory rheumatic diseases (IRD) inpatients are at higher risk to develop a severe course of SARS-CoV-2 infections compared to the general population, data from the German COVID-19 registry for IRD patients and data from the Lean European Survey on SARS-CoV-2 (LEOSS) infected patients covering inpatients from the general population with SARS-CoV-2 infections were compared.Methods4310 (LEOSS registry) and 1139 cases (IRD registry) were collected in general. Data were matched for age and gender. From both registries, 732 matched inpatients (LEOSS registry: n = 366 and IRD registry: n = 366) were included for analyses in total.ResultsRegarding the COVID-19 associated lethality, no significant difference between both registries was observed. Age &gt; 65°years, chronic obstructive pulmonary disease, diabetes mellitus, rheumatoid arthritis, spondyloarthritis and the use of rituximab were associated with more severe courses of COVID-19. Female gender and the use of tumor necrosis factor-alpha inhibitors (TNF-I) were associated with a better outcome of COVID-19.ConclusionInflammatory rheumatic diseases (IRD) patients have the same risk factors for severe COVID-19 regarding comorbidities compared to the general population without any immune-mediated disease or immunomodulation. The use of rituximab was associated with an increased risk for severe COVID-19. On the other hand, the use of TNF-I was associated with less severe COVID-19 compared to the general population, which might indicate a protective effect of TNF-I against severe COVID-19 disease.
Development and clinical validation of a dual ddPCR assay for detecting carbapenem-resistant Acinetobacter baumannii in bloodstream infections
Authors: Kou Xiaoxia , Zhu Detu , Zhang Yandong , Huang Liyan , Liang Jiawei , Wu Ziman , Liu Ze , Guan Chushi , Yu Lin 
Published: March 2024

ObjectiveAcinetobacter baumannii (A. baumannii, AB) represents a major species of Gram-negative bacteria involved in bloodstream infections (BSIs) and shows a high capability of developing antibiotic resistance. Especially, carbapenem-resistant Acinetobacter baumannii (CRAB) becomes more and more prevalent in BSIs. Hence, a rapid and sensitive CRAB detection method is of urgent need to reduce the morbidity and mortality due to CRAB-associated BSIs.MethodsA dual droplet digital PCR (ddPCR) reaction system was designed for detecting the antibiotic resistance gene OXA-23 and AB-specific gene gltA. Then, the specificity of the primers and probes, limit of detection (LOD), linear range, and accuracy of the assay were evaluated. Furthermore, the established assay approach was validated on 37 clinical isolates and compared with blood culture and drug sensitivity tests.ResultsThe dual ddPCR method established in this study demonstrated strong primer and probe specificity, distinguishing CRAB among 21 common clinical pathogens. The method showed excellent precision (3 × 10−4 ng/μL, CV &lt; 25%) and linearity (OXA-23: y = 1.4558x + 4.0981, R2 = 0.9976; gltA: y = 1.2716x + 3.6092, R2 = 0.9949). While the dual qPCR LOD is 3 × 10−3 ng/μL, the dual ddPCR’s LOD stands at 3 × 10−4 ng/μL, indicating a higher sensitivity in the latter. When applied to detect 35 patients with BSIs of AB, the results were consistent with clinical blood culture identification and drug sensitivity tests.ConclusionThe dual ddPCR detection method for OXA-23 and gltA developed in this study exhibits good specificity, excellent linearity, and a higher LOD than qPCR. It demonstrates reproducibility even for minute samples, making it suitable for rapid diagnosis and precision treatment of CRAB in BSIs.
Delipid extracorporeal lipoprotein filter from plasma system: a new intensive lipid lowering therapy for patients with acute ischemic stroke
Authors: Jiao Yuqiong , Yang Qi , Ye Ting , Zhu Jun , Li Qunyi , Han Xiang , Dong Qiang 
Published: March 2024

ObjectivesTo investigate the safety and efficacy of the delipid extracorporeal lipoprotein filter from plasma (DELP) system, a new low-density lipoprotein cholesterol (LDL-C) adsorption system, in acute ischemic stroke (AIS) patients.Patients and methodsIn the present study, a total of 180 AIS patients were enrolled during March 2019 to February 2021. They were divided into DELP group (n1 = 90) and the control group (n2 = 90). The treatment protocol and vascular access of DELP treatment was established and evaluated. For the DELP group, clinical data and laboratory results including plasma lipid and safety parameters before and after the apheresis were collected and analyzed. For all participants, neurological scores were assessed and recorded.ResultsFor the DELP group, 90 patients including 70 males and 20 females were included. The mean LDL-C was significantly decreased from 3.15 ± 0.80 mmol/L to 2.18 ± 0.63 mmol/L (30.79%, p &lt; 0.001) during a single DELP treatment, and decreased from 3.42 ± 0.87 mmol/L to 1.87 ± 0.48 mmol/L (45.32%, p &lt; 0.001) after two DELP treatments. No clinically relevant changes were observed in hematologic safety parameters and blood pressure levels except for hematocrit and total protein throughout the whole period of DELP treatment. The DELP group showed improvement relative to the control group in National Institute of Health stroke scale scores (NIHSS) on the 14th and 90th day after stroke. Moreover, the DELP group had a significantly higher ratio of mRS 0 to 1 on the 90th day after stroke.ConclusionThe new LDL-C adsorption system, the DELP system, may provide a new option for intensive lipid lowering therapy in AIS patients in view of its safety, efficacy, and operation feasibility.