bluuebunny/crossref_metadata_2025_split huggingface dataset:
Five‐year results from a randomized, controlled trial on early and delayed loading of implants supporting full‐arch prosthesis in the edentulous maxilla
Authors: Fischer Kerstin , Stenberg Torsten , Hedin Måns , Sennerby Lars 
Published: March 2008

AbstractObjectives: The overall aim was to compare the clinical outcomes of early and delayed implant loading in the totally edentulous maxilla during 5 years of function.Materials and methods: Twenty‐four patients with edentulous maxillae were randomized in two groups and subjected to early (test, n=16) or delayed (control, n=8) loading. A total of 142 implants were placed and 139 implants (Straumann AG) were loaded with full‐arch bridges and followed for 5 years.Results: All patients received and maintained a fixed bridge throughout the study period. Five (5.3%) test implants in three patients and two (4.3%) control implants in two patients were lost during the 5 years (NS). There were no differences in implant stability as measured with resonance frequency analysis at 5 years. More bone loss occurred at test than at control implants, −0.8 mm (SD 1.2) vs. −0.3 mm (SD 1.1), respectively. However, test implants showed a more coronal marginal bone level than control implants after 5 years, 2.9 mm (SD 1.1) vs. 3.7 mm (SD 1.2) from the implant shoulder, respectively. No control implants and four (4.4%) test implants in three (18.8%) patients showed >3 mm bone loss after 5 years. Two of the latter implants in one patient also showed increased probing depths, bleeding at probing and plaque accumulation. Tooth fracture was the most common prosthetic complication. The use of lingual gold onlay effectively reduced the number of resin‐related complications as opposed to a resilient mouth guard.Conclusions: The present randomized controlled trial showed no important differences between early and delayed loading of implants in the edentulous maxilla after 5 years of function. A favourable long‐term marginal bone response to the sandblasted large‐grit acid‐etched (SLA) surface was observed. Technical complications were mainly resin‐related which could be avoided by the use of a lingual gold onlay. It is concluded that early loading of SLA‐surface implants for support of full‐arch bridges represents a viable therapy for the totally edentulous maxilla.
Successful therapy of pemphigus vulgaris with immunoadsorption using the TheraSorb™ adsorber
Authors: Günther Claudia , Laske Jörg , Frind Antje , Julius Ulrich , Pfeiffer Christiane 
Published: March 2008

SummaryPemphigus vulgaris (PV) is caused by autoantibodies to desmogleins. Standard immunosuppressive therapy may be limited by concomitant diseases or ineffective.In these cases, removal of circulating antibodies by immunoadsorption can induce remission.An 87‐year‐old woman with PV and considerable co‐morbidities suffered from extensive mucous membrane erosions and bouts of skin blistering refractory to treatment with methotrexate,as well as mycopheno‐late mofetil and corticosteroids even when combined with plasmapheresis and intravenous immunoglobulin. Adjuvant immunoadsorption therapy with the TheraSorb™ columns‐first weekly, than monthly‐induced a complete remission, as well as a parallel decrease in PV antibody titers. Continued therapy for 18 months kept the patient in remission but for one infection‐related relapse, and remission has been stable over two further years on low‐dose methotrex‐ate monotherapy. This case confirms the clinical efficacy of immunoad‐sorption in PV and adds another type of adsorber column to the armamentarium, which is useful to the dermatologist who has to cooperate with local lipid apheresis or dialysis units.
The Schnitzler syndrome: Chronic urticaria and monoclonal gammopathy – an autoinflammatory syndrome?
Authors: Eiling Elisabeth , Schröder Johann O. , Gross Wolfgang L. , Kreiselmaier Inga , Mrowietz Ulrich , Schwarz Thomas 
Published: March 2008

SummarySchnitzler syndrome describes the simultaneous occurrence of monoclonal gammopathy and chronic urticaria with at least two additional minor symptoms (arthralgia, bone pain, fever of uncertain origin, hepato‐ or splenomegaly, lymphadenopathy, increased erythrocyte sedimentation rate, leukocytosis/thrombocytosis or increased bone density). Schnitzler syndrome is not wellknown and very likely under‐recognized. Comprehensive diagnostic examinations are necessary to rule out other diseases, especially those of hematologic origin. Close interdisciplinary collaboration is mandatory. The etiology of Schnitzler syndrome is unclear, but the rapid response to the interleukin‐1 receptor inhibitor anakinra underlines the pivotal role which the proinflammatory cytokine interleukin‐1 may play in the pathophysiology of this potentially autoinflammatory disorder.
Interdisciplinary management recommendations for toxicity associated with interferon‐alfa therapy
Authors: Hauschild Axel , Kähler Katharina C. , Schäfer Martin , Fluck Michael 
Published: March 2008

SummaryAdjuvant interferon‐α (IFN‐α) therapy in patients with melanoma has been established as standard therapy since more than 10 years.During IFN‐α therapy, flu‐like symptoms, gastrointestinal disorders, arthralgias and neuropsychiatric symptoms are the most common side effects. The management and prophylaxis of these side effects have been improved by a more detailed understanding of pathophysiologic mechanisms and increased clinical experience. New insights in the relevance of detection of autoantibodies and development of autoimmunity have influenced the clinical pathway substantially. This review covers the pathomechanisms, incidence and optimized therapy of IFN‐α‐associated side effects.
Appetitive and Aversive Classical Conditioning of Female Sexual Response
Authors: Both Stephanie , Laan Ellen , Spiering Mark , Nilsson Tove , Oomens Sanne , Everaerd Walter 
Published: March 2008

AbstractIntroductionThere is only limited evidence for appetitive classical conditioning of female sexual response, and to date modulation of female sexual response by aversive conditioning has not been studied.AimThe aim of this article is to study appetitive and aversive classical conditioning of sexual responses in women.Main Outcome MeasuresVaginal pulse amplitude was assessed by vaginal photoplethysmography and ratings of affective value were obtained.MethodTwo differential conditioning experiments were conducted. In Experiment 1, on appetitive conditioning, neutral pictures served as conditional stimuli (CSs) and genital vibrotactile stimulation as the unconditional stimulus (US). In Experiment 2, on aversive conditioning, erotic pictures served as CSs and a pain stimulus as US. In both experiments, only one CS (the CS+) was followed by the US during the acquisition phase. Conditioned responses were assessed during the extinction phase.ResultsIn Experiment 1, during the extinction phase, as expected vaginal pulse amplitude was higher in response to the CS+ than during the CS−. Also, the CS+ was rated as marginally more positive than the CS−. In Experiment 2, during the extinction phase, as expected vaginal pulse amplitude was lower in response to the CS+ than during the CS−, and the CS+ was rated as more negative than the CS−.ConclusionsThe results provide evidence for appetitive classical conditioning of sexual response in women, and are the first to show attenuation of sexual response in women by aversive conditioning.
Correlation of histology of healed fractures and tissue surrounding implants with ultrasonographic and radiographic appearance
Authors: Risselada M. , Van Bree H. , Kramer M. , Chiers K. , Duchateau L. , Verleyen P. 
Published: March 2008

Objectives: To determine if there was histological correlation with ultrasonographic images of healed fractures and implant‐associated tissue after fracture treatment by plate osteotomy. Methods: Eight adult dogs were included in this retrospective study. Ultrasonography (B‐mode and power Doppler) and radiography were performed before plate removal. Surgical biopsies were taken of the fracture site and the tissue adjacent to the plate. These were stained with haematoxylin and eosin to assess histomorphology and bone content and immunolabelled with CD31 to assess vascularity. Results: Ultrasound and radiographic diagnoses of a healed fracture correlated with histological finding of bone healing. Ultrasonography and histology findings of vascularity were also highly correlated. The tissue surrounding the surgical implants was significantly more vascularised on both ultrasonography and histology than that at the fracture site itself. Clinical Relevance: Ultrasonography can be used to diagnose fracture healing in plated fractures. Power Doppler ultrasonography examination of fracture healing should be performed away from surgical implants to avoid false‐positive results of vascularisation.
Modified functional end‐to‐end stapled intestinal anastomosis: technique and clinical results in 15 dogs
Authors: White R. N. 
Published: March 2008

Objectives: To evaluate the use of a gastrointestinal anastomosis (GIA) stapling device to perform small intestinal anastomosis in the dog. Methods: A retrospective study to evaluate the use of a GIA stapling device to perform small intestinal anastomosis in 15 dogs. Results: Reasons for intervention included dehiscence of a previous enterotomy (four of 15), intestinal neoplasia (five of 15), vascular compromise (three of 15), intussusception (two of 15) and foreign body (one of 15). The mean time taken to perform the anastomosis was 7·7 minutes (range five to 12 minutes). No operative complications were recorded and all dogs recovered from the surgery. Major (two dogs) and minor (six dogs) short‐term complications of pyrexia and anorexia were recorded in six dogs. In five of these, the cause was considered to be related to a pre‐existing peritonitis. One dog was euthanased five months postoperatively for a multi‐centric recurrence of intestinal lymphoma. Six month follow‐up confirmed an unremarkable and complete recovery in all remaining dogs. No major or minor long‐term complications were recorded in any individual. Clinical Significance: A modified stapled functional end‐to‐end intestinal anastomosis holds merit and should be considered a viable alternative to other stapled and sutured anastomosis techniques.
Retrospective review of 50 canine nasal tumours evaluated by low‐field magnetic resonance imaging
Authors: Avner A. , Dobson J. M. , Sales J. I. , Herrtage M. E. 
Published: March 2008

Objectives: Low‐field magnetic resonance imaging machines are being used more often in veterinary practice for the investigation of sinonasal disease. The aim of this retrospective study was to describe and characterise the low‐field magnetic resonance imaging features of nasal tumours in dogs. Methods: The Queen’s Veterinary School Hospital magnetic resonance imaging database (2001‐2005) was searched for dogs with a magnetic resonance imaging diagnosis of a nasal tumour. Fifty cases with histological diagnosis of nasal tumour were found. The appearance and extent of the nasal tumour as well as the involvement of adjacent anatomic structures were examined against a checklist. Results: The most common magnetic resonance imaging findings were as follows. (1) Soft tissue mass replacing the destroyed nasal conchae and/or ethmoturbinates (98 per cent of cases). (2) Nasal septum destruction (68 per cent of cases). (3) Retained secretions with or without mass caudally in frontal sinuses (62 per cent of cases). (4) Nasal/frontal bone destruction (52 per cent of cases). Low‐field magnetic resonance imaging allowed differentiation of tumour tissue from retained secretions or necrotic tissue. Magnetic resonance imaging was invaluable in assessing the extension of the tumour into the maxillary recesses, caudal recesses, nasopharynx, adjacent bones and cranial cavity. The tumour often extended caudally into the frontal sinuses, nasopharynx and perhaps most importantly into the caudal recesses. Tumour extension into the cranial cavity was not common (16 per cent), and only three of these cases showed neurological signs. However, 54 per cent of cases showed focal meningeal (dural) hyperintensity, although the significance of this is unclear. A significant difference (P<0·05) in tumour signal intensity between the sarcomas and carcinomas was found. Clinical Significance: The use of a low‐field magnetic resonance imaging technique is excellent for the diagnosis and determination of extent of sinonasal tumours.
MicroRNA Involvement in Brain Tumors: From Bench to Bedside
Authors: Nicoloso Milena S. , Calin George A. 
Published: March 2008

AbstractMicroRNAs (miRNAs), a novel class of small non‐coding RNAs, are effective post‐transcriptional regulators of gene expression, exhibiting, when altered in human tumors, both oncogenic and tumor suppressive potential. Recently, miRNA involvement in the pathophysiology of brain cancer has been assessed. Aberrant gene expression is the main mechanism of miRNAs dysfunction in cancer, with abnormal expression levels of mature and/or precursor miRNA expression in tumor samples versus normal. MiRNA germline and somatic mutations or polymorphisms in the protein coding messenger RNA targeted by miRNAs may also occur, contributing to cancer predisposition, initiation and/or progression. If present in somatic cells, miRNA alterations may play a role in tumor initiation, while if present in germ line cells they could constitute a cancer predisposing event. MiRNA expression profiling of human tumors has led to the identification of signatures correlated with the tumor diagnosis, staging, progression, prognosis and response to treatment. MiRNA fingerprinting can therefore be added to the diagnostic and prognostic tools used by medical oncologists. Furthermore, new therapeutic strategies involving miRNA silencing or miRNA mimics could be proposed based on the roles of these small non‐coding RNAs as oncogenes and tumor suppressors in brain tumors.
Generation Me, the Origins of Birth Cohort Differences in Personality Traits, and Cross‐temporal Meta‐analysis
Authors: Twenge Jean M. 
Published: March 2008

AbstractBirth cohort, or generation, differences in personality include views of the self (increases in self‐esteem, narcissism, assertiveness, and agentic traits, leading to the label ‘Generation Me’) and mental health (externality in locus of control, increases in depressive symptoms). The origins of these trends lie in culture, including changes in women's roles, parenting, media, and social connections. Birth cohort should be considered as an environmental influence on individual personality traits. Challenges to cross‐temporal meta‐analysis are discussed, including response bias, changes in college populations, data from the University of California campuses with major confounds, sampling issues, and the misperception that the ecological fallacy is committed.
Social Psychology and Media: Critical Considerations
Authors: Chamberlain Kerry , Hodgetts Darrin 
Published: March 2008

AbstractIn this paper, we argue that media saturate everyday living, and that people engage with and are engaged by media in diverse and complex ways. We suggest a need for an informed social psychology of media that conceptualises media as social practice, and attends to media practices as they occur. We propose that much media psychology research is limited because it: (i) focuses too strongly on documenting causal, and usually negative, media effects; (ii) continues to apply unsuitable research methodologies and theories to investigating media and ignores advances in media research and theory arising outside the discipline; and (iii) largely ignores the social contexts in which media engagements occur. These arguments are illustrated by studies that take a more social and critical approach to media research and that show possibilities for overcoming these limitations and developing insights into psychological concerns enmeshed in media practices.
Measurement of optic disc parameters on digital fundus photographs: algorithm development and evaluation
Authors: Bartling Herman , Wanger Peter , Martin Lene 
Published: March 2008

Abstract.Purpose:  To develop and evaluate a simple and rapid algorithm for optic disc measurements on digital fundus photographs, relying on the macula–disc centre distance as a reference when converting length expressed in pixels to metric distance.Methods:  Measurements were performed on fundus photographs from 68 normal subjects, acquired using five different cameras. The magnification factor and actual size in μm of 1 pixel was known for only one camera. The measurements from this camera were compared to corresponding measurements from a confocal scanning laser ophthalmoscope.Results:  Using the described algorithm, no significant differences in mean disc or cup size were observed between the tested cameras, despite differences in magnification factor (range 0.5–2.5). There were no significant differences between disc and cup measurements obtained with the confocal scanning laser ophthalmoscope and those obtained with the described algorithm in the 20 subjects examined.Conclusion:  The algorithm described in the current study provided clinically relevant measurements of optic disc parameters. The final program can be used directly on the acquired images, with the examined subject still available for re‐examination.
Subjective visual sensations during cataract surgery performed under topical anaesthesia
Authors: Biró Zsolt , Schvöller Mónika 
Published: March 2008

Abstract.Purpose:  To examine the patient’s subjective visual sensations during cataract surgery performed under topical anaesthesia.Methods:  Prospective, non‐randomized, cohort study. One hundred and thirty‐two patients were interviewed by standard questionnaire within 1 hr of uncomplicated cataract surgery performed under topical anaesthesia.Results:  Everyone saw lights of different and changing intensity. One hundred and twenty‐six (95.5%) patients saw different colours; 18 (13.6%) patients saw a rainbow‐like scale of colours. Ninety‐eight (74.2%) patients could see clear shapes and forms (mainly circle, square, rectangle, ellipse). Forty‐nine (37.1%) patients could see instruments, and 35 (26.5%) patients saw the fingers of the surgeon during surgery. Twenty‐six patients (19.7%) considered the strong light of the microscope very disturbing and uncomfortable. Forty‐seven patients made drawings of the visual sensations that they experienced during surgery.Conclusion:  Consistent with our review of the literature, we found no relation between intraoperative visual sensations and patient’s age, sex, preoperative visual acuity, duration of surgery or cataract severity. We found that it is helpful to inform the cataract patients of potential visual sensations before their surgery.
Seasonal variation of storage substances in stem cells of Diapensia lapponica. A light microscopic study
Authors: Pihakaski‐Maunsbach Kaarina , Walles Björn 
Published: March 2008

Owerwintering strategy of the sub‐arctic evergreen Diapensia lapponica has been studied by examining storage substances in the stem cells throughout different seasons. Stem segments were taken from 5 and 20 mm behind the shoot tip, fixed in glutaraldehyde/formaldehyde and embedded in Epon. Semithin sections were stained with Toluidine blue for general observation, Sudan black for lipids, Amido black for proteins and periodic acid‐Schiff s reagent (PAS) for carbohydrates. Lipids occurred abundantly throughout the year and seem to be the main storage substances. They were particularly common in mid‐winter in the lower part of the shoot. The highest lipid content was found in the pith cells and parenchyma cells of the conductive tissues. Large amyloplasts appeared in mid‐summer in higher amounts in the cortex than in the pith of the upper shoot, but vice versa in the lower stem. Starch was almost entirely lacking from November to April. Amido black staining did not indicate presence of protein bodies at any season.The occurrence of lipids and starch grains in the stem of Diapensia is in general similar to the occurrence of these substances in the leaves throughout the annual cycle.
Morphology, ontogeny and histochemistry of secretory trichomes of Geranium robertianum (Geraniaceae)
Authors: Pedro L. , Campos P. , Pais M. S. 
Published: March 2008

Geranium robertianum bears three types of glandular uniseriate trichomes which originate from a single protodermal cell and develop through periclinal divisions. Type I trichomes are procumbent and have an oval apical cell, two stalk cells and a basal cell. Type II trichomes are erect and have a pear shaped apical cell, two stalk cells and a basal cell. Type III trichomes are much longer than the other two types and have an elongated apical cell, five long stalk cells and a basal cell. Type I and type II trichomes are common on leaves while III trichomes are more abundant on flower structures.Type I and type II trichomes secrete terpenoids and phenols. Type III trichomes are characterized by the accumulation of anthocyanins in the apical cell and secrete flavonoids.
Studies on the type species of Compsonema, C. minutum (Fucophyceae, Scytosiphonales); aspects of life history, taxonomic position, shedding of wall elements and plasmodesmata
Authors: Pedersen Poul Møller , Sokhi Gunwant 
Published: March 2008

Compsonema minutum, the type species of the genus, shows two features which are characteristic for the Scytosiphonales: the presence of a single large lobed chloroplast per cell with a large pyrenoid in a pyrenoid sac, and a partly parenchymatous prostrate system morphologically similar to the knot filaments in the comparable thallus parts of, for example, Scytosiphon and Petalonia. The genus, therefore, finds a natural position in the Scytosiphonales.The direct type of life history seems to dominate in the reproductive pattern as swarmers from the plurilocular sporangia develop without copulation into plants similar to the parental plant. One unilocular sporangium has been observed but the fate of the swarmers from this reproductive structure has not been determined. The fine structural background for the formation of overlapping wall elements has been investigated. Lacunae develop between the layers in the 2‐layered wall and the outermost part of the wall gradually becomes electron dense. During growth the electron dense part breaks away to become separated from the rest of the wall in the area with lacunae.The plasmodesmata in the transverse walls show a single membrane profile similar to for example Fucus, i.e. the pores provide continuity but lack desmotubules and ER.