bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of MicrOnized Purified Flavonoid Fraction in PoST-Hemorrhoidectomy Period (MOST Trial): Open-Label Randomized Controlled Trial
Authors: Medkova Yuliya , Tulina Inna , Yudina Valeriya , Abdullaev Ruslan , Vlada Scherbakova , Novikov Ivan , Nikonov Andrey , Tsarkov Petr 
Published: February 2024

BACKGROUND:
Frequent early postoperative complication of hemorrhoidectomy is thrombosis and edema of mucocutaneous “bridges.”

OBJECTIVE:
We investigated the efficacy of micronized purified flavonoid fraction in preventing complications following elective hemorrhoidectomy.

DESIGN:
Prospective unicentral open-label randomized controlled trial.

SETTINGS:
2021-2022 Clinic of Colorectal and Minimally Invasive Surgery Sechenov University (Moscow, Russia).

PATIENTS:
Patients after hemorrhoidectomy, which was done for grade III-IV hemorrhoids

INTERVENTIONS:
After hemorrhoidectomy, patients were randomly allocated either to standard treatment (peroral non-steroid anti-inflammatory drugs and local anesthetics, topical steroids, psyllium, warm sitz baths, nifedipine gel) – control group, or to standard treatment with micronized purified flavonoid fraction (study group) and followed for 60 days.

MAIN OUTCOME MEASURES:
Thrombosis or edema of mucocutaneous bridges and pain intensity on a visual analogue scale оn 1st-7th, 14th , 21st and 30th postoperative day; quality of life and patient-assessed treatment effect оn 1st, 3rd, 7th, 21st and 30th postoperative day; perianal skin tags оn 60th postoperative day.

RESULTS:
The data from 50 patients were analyzed (25 in each group). Visual analogue scale demonstrated nо differences between groups in each follow-up point. Compared to control group, the patients in study group had significantly higher patient-assessed treatment effect оn 1st, 3rd, 7th, 21st and 30th post operative days, significantly lower rate of thrombosis or edema of mucocutaneous bridges оn 1st-7th, and 14th days. Patients in the study group had significantly lower rates of perianal skin tags.

LIMITATIONS:
Unicenter open-label design.

CONCLUSIONS:
Micronized purified flavonoid fraction in the post-hemorrhoidectomy period is an effective adjunct to standard treatment that helps reduce the rate of thrombosis and edema of mucocutaneous bridges, improves patient-assessed treatment effect, and prevents postoperative perianal skin tags formation. Micronized purified flavonoid fraction in the post-hemorrhoidectomy period is not associated with additional pain relief in comparison with non-micronized purified flavonoid fraction standard treatment. See Video Abstract.
Traumatic scrotal sac hematoma after a fall injury
Authors: Kafle Rijan , Yogi Tek Nath , Bartaula Sanjok , Bhusal Amrit , Labh Sujal , BK Himal , Malla Nakendra , Gahatraj Manish 
Published: February 2024

Introduction and Importance:
Traumatic scrotal sac hematoma is an uncommon medical condition following a fall injury. Symptoms include swelling, pain, and discoloration. Accurate and immediate diagnosis is crucial to avoid complications and prevent testis loss, abscess formation, erectile dysfunction, and infection. This case highlights the importance of prompt evaluation and treatment to prevent complications and ensure optimal patient outcomes.

Case Presentation:
A 56-year-old man without prior medical history presented to the emergency department with scrotal pain and swelling 10 h after a traumatic event. The patient underwent a series of examinations, including radiological studies, before undergoing scrotal exploration and hematoma evacuation under subarachnoid block anesthesia. As of now, the patient has not experienced any complications that have impacted his quality of life.

Clinical Discussion:
Scrotal sac hematoma is formed following a blunt trauma when a significant force is transferred during contact with a solid object, impact from sports equipment, road traffic accidents, or falls from a height. If early exploration is delayed, then it can lead to complications like testicular atrophy, abscess formation, and infection. Hence, prompt diagnosis with clinical and radiological evaluation followed by immediate surgical intervention can result in better outcomes.

Conclusion:
Scrotal sac hematoma from blunt trauma is rare but can cause significant morbidity and psychological distress. Early surgical intervention is often necessary, especially if a testicle has ruptured, to salvage viable testicular tissue and control bleeding, resolve pain faster, shorten hospital stays, and improve the quality of life for patients.
Use of the “Sepsis Risk Calculator” in Belgian Newborns: A Retrospective Cohort Study
Authors: Langer Bianca I. , Johansson Anne-Britt , Mathé Karin , Jourdain Sarah , Smeesters Pierre R. 
Published: February 2024

Background:
Prevention of early-onset neonatal sepsis (EONS) is a frequent reason why many newborns receive unnecessary antibiotics. The Sepsis Risk Calculator (SRC) was developed by the Kaiser Permanente Institute as a multivariate risk assessment of EONS, aiming to reduce laboratory testing and empiric neonatal antibiotic therapy. Our objective was to assess the potential of the SRC in reducing antibiotic use in our setting.

Methods:
Late preterm and term newborns who received antibiotics from 2019 to 2020 in a tertiary Belgian hospital were included. Newborn-specific data were collected and entered into the online SRC, retrospectively calculating a sepsis risk score and providing recommendations for antibiotic administration. False-positive indications for treatment by the SRC were estimated based on previously published data. Antibiotic therapy rates according to the SRC recommendations were compared to the actual rate of antibiotic therapy.

Results:
Of 5891 births, 414 newborns received antibiotics and were eligible for this study, representing a rate of 7.6% of newborns receiving antibiotics following our current guidelines. The SRC would have recommended antibiotic administration for 2.7%, reducing antibiotic therapy by 64.5%. Of 5 possible cases of EONS, 3 would have received antibiotics in the first 24 hours according to the SRC.

Conclusions:
In this Belgian cohort, use of the SRC has the potential to significantly decrease by 64.5% the newborns that receive antibiotics. This reduction would primarily concern asymptomatic newborns. If use of the SRC was to be implemented in Belgian maternities, strict clinical surveillance practices should be ensured.
Do current methods of measuring the impact of chronic pain on work reflect the experience of working-age adults? An integrated mixed-methods systematic narrative review
Authors: Stagg Anne L. , Madan Ira , Fear Nicola , Stevens Martin J. , Wainwright Elaine , Hoving Jan L. , Macfarlane Gary J. , Hollick Rosemary , Morton LaKrista ,   on behalf of the QUICK Study Investigators
Published: February 2024

Abstract
Chronic pain affects individuals' work participation. The impact of chronic pain on work has historically been measured through sickness absence, though it is now appreciated that the impacts on work are far wider. This mixed-methods review aimed to identify the full range of impacts of pain on work in addition to impacts that are currently measured quantitatively to inform the development of a new questionnaire assessing the wider impacts of chronic pain on work. MEDLINE, Embase, PsychINFO, and CINAHL were searched for studies that included quantitative measures of the impact of chronic pain on work and for qualitative studies where individuals described impacts of their chronic pain on work. Quantitative measures, and text from qualitative studies, were analysed thematically. A thematic framework was developed for establishing the types of impacts measured or described in the literature. Forty-four quantitative and 16 qualitative papers were identified. The literature described impacts within 5 areas: changes at work and to working status; aspects of the workplace and work relationships; pain and related symptoms at work; psychological factors; and factors and impacts outside the work environment related to work. Quantitative measures mainly assessed impacts related to the quantity and quality of work (29 of 42 measures). Seventeen aspects were only discussed within the qualitative literature. This study identifies a discrepancy between the impacts that have been the focus of quantitative measures and the range that individuals working with chronic pain experience and highlights the need for a new measure assessing a wider range of issues.
Chemotherapy-induced peripheral neuropathy models constructed from human induced pluripotent stem cells and directly converted cells: a systematic review
Authors: Smulders Pascal S.H. , Heikamp Kim , Hermanides Jeroen , Hollmann Markus W. , ten Hoope Werner , Weber Nina C. 
Published: February 2024

Abstract
Developments in human cellular reprogramming now allow for the generation of human neurons for in vitro disease modelling. This technique has since been used for chemotherapy-induced peripheral neuropathy (CIPN) research, resulting in the description of numerous CIPN models constructed from human neurons. This systematic review provides a critical analysis of available models and their methodological considerations (ie, used cell type and source, CIPN induction strategy, and validation method) for prospective researchers aiming to incorporate human in vitro models of CIPN in their research. The search strategy was developed with assistance from a clinical librarian and conducted in MEDLINE (PubMed) and Embase (Ovid) on September 26, 2023. Twenty-six peer-reviewed experimental studies presenting original data about human reprogrammed nonmotor neuron cell culture systems and relevant market available chemotherapeutics drugs were included. Virtually, all recent reports modeled CIPN using nociceptive dorsal root ganglion neurons. Drugs known to cause the highest incidence of CIPN were most used. Furthermore, treatment effects were almost exclusively validated by the acute effects of chemotherapeutics on neurite dynamics and cytotoxicity parameters, enabling the extrapolation of the half-maximal inhibitory concentration for the 4 most used chemotherapeutics. Overall, substantial heterogeneity was observed in the way studies applied chemotherapy and reported their findings. We therefore propose 6 suggestions to improve the clinical relevance and appropriateness of human cellular reprogramming–derived CIPN models.
Case report: GCA like picture-preceding inaugural MOGAD presentation: A patient with a sudden-onset uniocular blindness
Authors: Zeng Yixuan , Liu Xuan , Bai Runtao , Zhou Yanxia , Ren Lijie 
Published: February 2024

Rationale:
Myelin oligodendrocyte glycoprotein antibody-associated disorders (MOGAD) represents a demyelinating neurological syndrome characterized by the presence of serum IgG antibodies directed against myelin oligodendrocyte glycoprotein (MOG-IgG). Concurrently, giant cell arteritis (GCA) constitutes a systemic autoimmune vasculitis.

Patient concerns:
In this case, we describe an elderly female patient who presented with the sudden onset of a severe headache, unilateral blindness, and clinical manifestations resembling those of GCA.

Diagnosis:
Upon conducting a comprehensive analysis of serum antibodies, the diagnosis of MOGAD was established due to the presence of detectable serum MOG-IgG.

Interventions:
Subsequently, the patient was administered intravenous methylprednisolone therapy, commencing 27 days after the initial onset of symptoms.

Outcomes:
It is noteworthy that patients afflicted by MOGAD typically manifest severe visual impairment, which, in many instances, exhibits significant improvement following immunotherapeutic interventions. However, this particular patient did not experience any amelioration in visual function despite glucocorticoid therapy.

Lessons:
This unique case illustrates that the clinical presentation resembling GCA may precede the inaugural manifestation of MOGAD. This suggests the possibility of immune-mediated arterial involvement. The significance of glucocorticoid therapy in the context of immune-related diseases warrants further scrutiny, particularly in cases where MOG-IgG screening should be promptly considered.
Immune checkpoint inhibitor induced colitis and arthritis: A case report
Authors: Xie Rong-Xin , Xue Yu-Bao , Ci Xin-Yu , Zhang Mei-Juan 
Published: February 2024

Rationale:
As a programmed cell death 1 (PD-1) inhibitor, camrelizumab is used in the treatment of a variety of malignancies. However, a variety of immune-mediated adverse reactions have been reported in a wide range of clinical applications, including immune-related colitis, arthritis, hepatitis, etc.

Patient concerns:
This 56-year-old male patient experienced diarrhea, bloody stool, and knee pain after receiving camrelizumab for metastatic esophageal squamous cell carcinoma. Colonoscopy showed granular changes in the whole colonic mucosa and blurred or even disappeared vascular texture. Pathology showed chronic inflammation of the colonic mucosa. Magnetic resonance imaging of knee joint showed exudative inflammatory changes in bilateral knee joints.

Diagnosis:
Immune checkpoint inhibitor-induced colitis and arthritis.

Interventions:
Mesalazine oral (extended-release granules, 1000 mg/quarter in die daily). Dexamethasone sodium phosphate (once daily, 5mg in the evening) and compound cypress liquid (once daily, 100ml in the evening) were given by enema. Anti-inflammatory and analgesic treatment of bone pain plaster.

Outcomes:
The patient had diarrhea reduced to 3 times/day, no more bloody stools, and the knee pain was relieved.

Lessons:
This article describes the cases of immune-related colitis and arthritis caused by camrelizumab, and recommends considering the risk of colitis and arthritis with camrelizumab monotherapy or combination therapy.
Visualization analysis of exercise intervention on Alzheimer disease based on bibliometrics: Trends, hotspots and topics
Authors: Jin Yu , Li Xue , Yuan Qiongjia , Huang Xiaohan , Zhang Deman 
Published: February 2024

Background:
As the challenges of an aging society continue to escalate, Alzheimer disease (AD) has emerged as a significant health, social, and public concern, garnering substantial attention. Exercise, as a safe, effective, and cost-efficient approach with the potential to mitigate brain aging, has garnered considerable interest. Nevertheless, there has been a limited research investigating the current trends, hotspots, and topics of exercise on AD.

Methods:
The literature spanning from 2013 to 2022 was obtained from the Web of Science database, and CiteSpace VI was employed to conduct an analysis encompassing fundamental data, keywords, and co-citation analysis.

Results:
A total of 9372 publications were included in the analysis. The annual number of publications has exhibited a gradual increase. The United States and China made significant contributions, with England showing higher citation rates and greater academic influence. The Journal of Alzheimers Disease, Neurosciences Neurology, Liu-Ambrose, Teresa represents the most published journal, discipline, and author, respectively. The research trends can be summarized as exploring functional changes and potential mechanisms related to exercise impact on AD. The hotspots in the research include the intersection of AD and diabetes mellitus, as well as the underlying effects induced by exercise. The topics of interest revolve around the application of emerging technologies in the context of exercise and AD.

Conclusion:
This bibliometric analysis has identified relevant trends, hotspots, and topics within the exercise intervention on AD. It offers a comprehensive overview that can equip researchers with valuable insights for future exploration and assist scholars in charting research trajectories in related domains.
Effect of RhD and RhE sample phenotypic blood transfusion on the prognosis of hepatocellular carcinoma
Authors: Zhang Ling , Wang Tao , Song Jieqiong , Guo Feng 
Published: February 2024

Objective:
This study aimed to analyze the therapeutic effects and clinical outcomes of HCC patients, who received both RhD and RhE same phenotypic blood transfusion during perioperative period.

Methods:
Microcolumn gel technology (MGT) was used to detect Rh blood group phenotyping in 98 HCC patients. Patients received RhD and RhE same phenotypic transfusion were defined experimental group, and those received only RhD same phenotypic but RhE different phenotypic transfusion were included in control group. Hemoglobin (Hb) and hematocrit (HCT) before and after perioperative transfusion were analyzed. The occurrence of adverse transfusion reactions were observed. Survival analysis was performed using the Kaplan–Meier method.

Results:
After the transfusion treatment, the Hb (118.9 ± 34.8 g/L vs 99.6 ± 26.9 g/L) and HCT [(34.0 ± 7.6)% vs (29.9 ± 8.8)%] of experimental group and the Hb (104.3 ± 36.2 g/L vs 94.8 ± 25.0 g/L) of control group were significantly higher than those before blood transfusion, respectively (all P < .05). In addition, Hb and HCT in experimental group were significantly higher than those in the control group after transfusion (P < .05). For the adverse blood transfusion reactions, the incidence of backache was reduced in the patients received Rh same phenotypic transfusion compared with those in control group (1.9% vs 15.2%, P = .024). The overall survival of patients in experimental group was better than that in control group (log-rank P = .036).

Conclusion:
Our study indicated that both RhD and RhE same phenotypic transfusion significantly increased Hb and HCT and reduced backache incidence than RhE different phenotypic transfusion in HCC patients. The overall survival of patients was improved by RhD and RhE same phenotypic transfusion.
Clinical value of ultrasound in adult Wilms’ tumor patient with uremia: A case report and literature review
Authors: Zhang Jing-Jing , Yang Li-Fei , Zhang Yi-Zhen , Xie Xiao-Hong 
Published: February 2024

Rationale:
Wilms' tumor (WT) is the most common pediatric kidney malignancy and is rarely found in adults. Nonspecific clinical symptoms and imaging features often lead to delayed diagnosis or misdiagnosis of adult WT, resulting in poor clinical outcomes. Ultrasound (US), as an efficient and noninvasive examination method, has been widely used in clinical diagnosis and treatment. Therefore, various US evidence is meaningful to improve understanding of adult WT characteristics in ultrasound.

Patient concerns:
A 45-year-old female patient with uremia (regular hemodialysis for 13 years) with painless gross hematuria was diagnosed with a right kidney tumor penetrating to the lung. Preoperatively, B-mode ultrasonography showed an ill-defined hyperechoic mass in the right kidney, which revealed an unclear border, uneven internal echoes, and calcification. Besides, the internal blood flow signal of the tumor was detected. Contrast-enhanced ultrasound (CEUS) showed an uneven hyper-enhancement in the tumor (“fast in and slow out”). Contrast-enhanced computed tomography of the kidney indicated a similar result as the CEUS. Moreover, the chest CT identified multiple pulmonary metastatic nodules.

Diagnoses:
An ultrasound-guided percutaneous core needle biopsy of the tumor proceeded to make a definite diagnosis of adult WT (epithelial type).

Interventions:
The patient was treated with tislelizumab.

Outcomes:
No progress was found to date.

Lessons:
We report the first case in which CEUS was performed in an adult WT patient with uremia and multiple pulmonary metastases. The features obtained by the US can help in the diagnosis of adult WT and direct further diagnostic procedures.
Incidence of histoplasmosis in patients receiving TNF-alpha inhibitors: A systematic review and meta-analysis
Authors: Cipolat Murillo M. , Rodrigues Débora R.R. , Brenol Claiton V. , Pasqualotto Alessandro C. , Falci Diego R. 
Published: February 2024

Background:
Immunobiological drugs such as TNF-α inhibitors are valuable in rescue therapy for autoimmune diseases such as rheumatoid arthritis and inflammatory bowel disease (IBD), but they increase the risk of infectious complications. Histoplasmosis is a significant concern in patients living in endemic regions, however, few studies have assessed the incidence of Histoplasma infection during therapy, and classic estimates may underestimate the risk. This study aimed to produce an updated risk estimate of histoplasmosis in patients on TNF-α blocking therapy.

Methods:
This is a systematic review and meta-analysis of studies that contain parameters for calculating the risk of histoplasmosis in people who use TNF-α inhibitors, to produce a risk estimate.

Results:
We identified 11 studies with the necessary parameters for inclusion in the meta-analysis, most of which were from North America. The incidence rate of histoplasmosis found was 33.52 cases per 100,000 patients treated with TNF-ɑ inhibitors (95% CI 12.28–91.46). Considering only studies evaluating monoclonal antibodies, the calculated incidence was 54.88/100,000 patients treated (95%CI 23.45–128.34). In subgroup analysis, the incidence was much higher in patients with IBD compared to rheumatic diseases. There was significant heterogeneity among the studies.

Conclusion:
The risk of histoplasmosis during TNF-α inhibitory therapy may be considerably higher than that found in classical estimates, especially in patients with IBD. There is a lack of studies evaluating histoplasmosis in large endemic areas, such as Central and South America.
Micropapillary or solid component predicts worse prognosis in pathological IA stage lung adenocarcinoma: A meta-analysis
Authors: Wang Yifan , Hu Jingguo , Sun Yu , Lu Yusong 
Published: February 2024

Background:
Micropapillary and solid patterns indicate worse survival in lung adenocarcinoma patients, even in pathological stage IB patients. However, whether the presence of micropapillary or solid components is related to worse prognosis in pathological IA stage lung adenocarcinoma remains unclear.

Methods:
Several databases were searched up to December 31, 2022 for relevant studies investigating the association between micropapillary and solid components and the survival of IA stage lung adenocarcinoma patients. Primary and secondary outcomes are disease-free survival (DFS) and overall survival (OS), respectively. Hazard ratios (HRs) and 95% confident intervals (CIs) were combined, and subgroup analysis stratified by the pathological subtype and proportion of components was further performed.

Results:
A total of 19 studies with 12,562 cases were included. Pooled results indicated that micropapillary or solid components obviously predicted worse DFS (HR = 2.40, 95% CI: 1.96–2.94, P < .001) and OS (HR = 2.30, 95% CI: 1.68–3.15, P < .001). Subgroup analysis based on pathological subtype showed that both micropapillary and solid components were significantly associated with worse DFS (micropapillary: HR = 2.70, 95% CI: 1.70–4.28, P < .001; solid: HR = 3.98, 95% CI: 2.10–7.54, P < .001) and OS (micropapillary: HR = 2.29, 95% CI: 1.17–4.48, P = .015; solid: HR = 4.18, 95% CI: 1.72–10.17, P = .002). In addition, further subgroup analysis stratified by the proportion of micropapillary and solid components (>5%/1% or predominant) showed similar results.

Conclusion:
Micropapillary and solid patterns predicted a significantly worse prognosis in pathological IA stage lung adenocarcinoma patients.