bluuebunny/crossref_metadata_2025_split huggingface dataset:
An examination of state and trait urgency in individuals with binge‐eating disorder
Authors: Wonderlich Joseph A. , Forester Glen , Crosby Ross D. , Engel Scott G. , Crow Scott J. , Peterson Carol B. , Wonderlich Stephen A. 
Published: April 2024

AbstractObjectiveNegative urgency (i.e., acting rashly when experiencing negative affect; NU), is a theorised maintenance factor in binge‐eating type eating disorders. This study examined the association between trait NU and eating disorder severity, momentary changes in state NU surrounding episodes of binge eating, and the momentary mechanistic link between affect, rash action, and binge‐eating risk.MethodsParticipants were 112 individuals with binge‐eating disorder (BED). Baseline measures included the UPPS‐P Impulsive Behaviour Scale to assess trait NU and the Eating Disorders Examination to assess binge‐eating frequency and global eating disorder severity. Ecological momentary assessment captured real‐time data on binge eating, negative affect, and state NU.ResultsMultiple regression analysis revealed a strong association between trait NU and eating disorder severity. Generalised estimating equations showed that state NU increased before and decreased after binge‐eating episodes, and that this pattern was not moderated by trait‐level NU. Finally, a multilevel structural equation model indicated that increases in rash action mediated the momentary relationship between states of high negative affect and episodes of binge eating.ConclusionThese findings underscore the importance of both trait and state NU in binge‐eating type eating disorders, and suggest NU as a potential key target for intervention.
Glacial and volcanic landforms in the upper catchment of Claro River, Central Chile (35.5°S): A Late Quaternary geomorphological case study
Authors: Mejías Osorio Paulina , Cortés‐Aranda Joaquín , Salas Pablo , Mardones María 
Published: April 2024

AbstractThe upper catchment of the Claro river is located within the Transitional Southern Volcanic Zone in the Maule Region of Chile (35.5°S), at the foothills of Manantial Pelado volcano, a Pleistocene stratovolcano whose morphology suggests the occurrence of important glacial processes in the area. The observed glacial landforms can be sequenced and associated with episodes of volcanic activity. Different units of volcanic and glacial origin were identified based on field observations, detailed mapping, and digital elevation model and satellite image analysis. The contact relations between them made it possible to discern four events that can be linked to Marine Isotope Stages 8, 6, 4‐2, and to the Neoglacial. We propose seven stages in the geomorphological evolution from the late Pleistocene to the late Holocene, where there is coexistence between volcanic and glacial episodes, such as the emplacement of the Manantial Pelado volcano overlying the Abanico and Cola de Zorro formations; a subsequent debris avalanche; the enlargement of the Del Indio valley during the Penultimate Glaciation; the construction of Cerro Redondo (a minor eruptive center at the head of Del Indio valley); ongoing fluvial incision; and Neoglacial advances. The relative chronology proposed in this work contributes to clarifying the Pleistocene–Holocene geomorphological history in this catchment and to further understand the interplay between volcanic and glacial processes in the central Chilean Andes during the Quaternary.
Hybrid forecasting of crude oil volatility index: The cross‐market effects of stock market jumps
Authors: Jiang Gongyue , Qiao Gaoxiu , Wang Lu , Ma Feng 
Published: April 2024

AbstractFrom the cross‐market perspective, this paper investigates crude oil volatility index (OVX) forecasts by proposing a hybrid method, which combines the data‐driven SVR technique and parametric models. In terms of parametric models, we utilize GARCH‐type models with jumps, and the forecasting effects of five non‐parametric jumps (including interday and intraday jump tests) of stock market are also explored. Empirical results show that our approach can substantially increase forecasting accuracy. In addition, the model confidence set test and robust test reaffirm the superiority of the novel hybrid method. From the assessment of economic significance, the advantages of the hybrid method for volatility index forecasting are further confirmed. All these findings imply that jumps of stock market can be helpful in forecasting OVX, especially after the introduction of the hybrid method. Our work can certainly provide a new insight for volatility forecasting and cross‐market research.
The role of community pharmacists and their perception towards antimicrobial stewardship in Baghdad, Iraq
Authors: Alkadhimi Akram , Dawood Omar T. , Khan Amer H. 
Published: April 2024

AbstractBackgroundThis study aimed to assess the role of community pharmacists and their perception toward antimicrobial stewardship, in addition to identifying factors influencing their perception and practices in community pharmacy.MethodsA cross‐sectional study was carried out among community pharmacists regarding antimicrobial stewardship. Convenience sampling was used to obtain the required sample from a community pharmacy in Baghdad. In total, 381 participants have completed the survey.ResultsThe majority of the participants (85.6%) strongly agreed/agreed that “antimicrobial stewardship programs reduce the problems of antibiotic resistance”; and 85.5% of them strongly agreed/agreed that community pharmacists required adequate training on antibiotics use. In addition, high percent of community pharmacists (88.4%) strongly agreed/agreed that pharmacists have a responsibility to take a prominent role in antimicrobial stewardship programs and infection‐control programs in the health system. The total score of perception was significantly influenced by older age groups, postgraduate degrees, and experience of 6–10 years (p < 0.001). This study also showed that 65.4% of pharmacists always/often advise patients to continue the full course of antimicrobials, and 64.9% of them reported always/often considering clinical and safety parameters before dispensing antibiotics. The role of pharmacists was significantly influenced by the younger age group, females, higher degree in pharmacy, experience of 3–5 years, and medical complex pharmacy (p < 0.001).ConclusionCommunity pharmacists have a good perception toward antimicrobial stewardship programs, but their role is still limited. More efforts are needed to design better strategies for antimicrobial stewardship in community pharmacy.
International guidelines for intratumoral and intranodal injection of NBTXR3 nanoparticles in head and neck cancers
Authors: Liem Xavier , de Baère Thierry , Vivar Omar I. , Seiwert Tanguy Y. , Shen Colette , Pápai Zsuzsanna , Moreno Victor , Takácsi‐Nagy Zoltán , Helfferich Frigyes , Thariat Juliette , Gooi Zhen , Yom Sue S. , Bossi Paolo , Ferris Robert L. , Hackman Trevor G. , Le Tourneau Christophe , Rodriguez Joseph , Hoffmann Caroline 
Published: April 2024

AbstractBackgroundAn international multidisciplinary panel of experts aimed to provide consensus guidelines describing the optimal intratumoral and intranodal injection of NBTXR3 hafnium oxide nanoparticles in head and neck squamous cell carcinoma (HNSCC) of the oral cavity, oropharynx, and cervical lymph nodes and to review data concerning safety, feasibility, and procedural aspects of administration.MethodsThe Delphi method was used to determine consensus. A 4‐member steering committee and a 10‐member monitoring committee wrote and revised the guidelines, divided into eight sections. An independent 3‐member reading committee reviewed the recommendations.ResultsAfter two rounds of voting, strong consensus was obtained on all recommendations. Intratumoral and intranodal injection was deemed feasible. NBTXR3 volume calculation, choice of patients, preparation and injection procedure, potential side effects, post injection, and post treatment follow‐up were described in detail.ConclusionsBest practices for the injection of NBTXR3 were defined, thus enabling international standardization of intratumoral nanoparticle injection.
Transoral robotic surgery with free flap reconstruction: Functional outcomes of 241 patients at a single institution
Authors: Kaki Praneet C. , Lam Doreen , Sangal Neel R. , Rajasekaran Karthik , Chalian Ara C. , Brody Robert M. , Weinstein Gregory S. , Cannady Steven B. 
Published: April 2024

AbstractBackgroundTransoral robotic surgery (TORS) for oropharyngeal malignancy optimizes oncologic outcomes while preserving functionality. This study identifies patterns of functional recovery after TORS with free flap reconstruction (FFR).MethodsRetrospective cohort study at a tertiary care center of patients with primary oropharyngeal tumors treated with TORS with FFR between 2010 and 2022. Patients were categorized into: adjuvant chemoradiation or radiation, or no adjuvant therapy (NAT). Functional outcomes were measured by functional oral intake scale (FOIS).Results241 patients were included. FOIS declined at first postoperative appointment (median = 7.0 to 2.0, IQR = [7.0, 7.0], [2.0, 4.0]), and progressively improved to 6.0 (5.0, 6.0) after 1 year, with NAT having the highest FOIS (7.0, p < 0.05). Predictors of poor long‐term FOIS included RT and hypoglossal nerve (CN XII) involvement (p < 0.05).ConclusionsTORS with FFR leads to good long‐term function with minimal intake restrictions. Radiation therapy and CN XII involvement increase risk of worse functional outcomes.
Available rehabilitation technology with the potential to be incorporated into the clinical practice of physiotherapists: A systematic review
Authors: e Siqueira Tarciano Batista , Parraça José , Sousa João Paulo 
Published: April 2024

AbstractBackgroundThe development of prototypes capable of intervening in the area of rehabilitation in physical therapy clinical practice activities that were previously carried out in a traditional way, that is, manually, demonstrates how technology is having an impact on professional careers such as physiotherapy.ObjectiveThe purpose of this study is to present a comprehensive examination of various technologies employed in the facilitation of patient rehabilitation, with a focus on their potential integration within the clinical practice of physical therapists.MethodsWe conducted a systematic search in four electronic databases (CINAHL, Embase, PEDro, and PubMed) for research on rehabilitation technologies. The eligible studies should demonstrate a clear utilization of technology in various aspects of the clinical approach to the rehabilitation process and have been published between 2000 and 2021 in either Portuguese or English.ResultsA total of 18 articles that satisfied the selection criteria were included in the study. The studies were classified into four distinct categories of rehabilitation technologies, which were determined by the specific characteristics of the technology employed and its integration with the therapeutic approach to rehabilitation. These categories include digital technologies, artificial intelligence and/or robotics, virtual technologies, and hybrid technologies.Implications on Physiotherapy PracticeRehabilitation technologies possess the capacity to effectively facilitate clinical activities performed by physical therapy professionals, including injury prevention, movement monitoring, and coordination of rehabilitation programs, with minimal or negligible intervention from the physical therapist. Further research is required to ascertain the precise capabilities of various technologies in collaborating with physiotherapists to deliver comprehensive care for patients' physical well‐being, encompassing both therapeutic and preventive approaches.Trial RegistrationPROSPERO registration number CRD42020222288
Exploring attitudinal barriers to participation in inpatient fall risk assessment using the Theoretical Domains Framework: A survey of providers
Authors: Carter Emily L. , Hallen Sarah A. M. , Welch Gavin W. , Gordon Erin N. , Parker Mark G. 
Published: April 2024

AbstractBackground and AimsLack of provider (physicians and advanced practice providers) participation in fall risk assessment was theorized to be contributing to rising rates of falls with injury at our institution. This project sought to identify if attitudinal barriers to inpatient provider participation in fall risk assessment were similar to those identified in other clinical settings.MethodsBarriers to provider participation in fall risk assessment were identified in the literature. These were mapped to the Theoretical Domains Framework (TDF) domains to assist with interpretation of the data. A 10‐item survey using a 5‐point Likert scale (strongly agree to strongly disagree) with two open‐ended questions was developed using these barriers. The survey was distributed via email to all providers on the Medical Staff in July 2021.ResultsThe response rate was 9.1% (188/2062). 72.6% (95% confidence interval [CI]: 65.6, 78.5) of providers at our institution did agree that fall risk assessment was within their role and 72% (95% CI: 66.1, 78.5) agreed that assessment can prevent falls. Nearly half felt that they lacked formal training in fall risk assessment (48.1% [95% CI: 41.1, 55.1]) and 52.2% (95% CI: 44.6, 58.6) agreed that other aspects of patient care took priority over falls assessment. These barriers correlated best with the TDF domains of Beliefs about Capabilities and Beliefs about Consequences.ConclusionsSurvey results indicate that interventions focused on increasing provider motivation and capability regarding fall risk assessment and helping providers prioritize fall risk assessment are potential targets for future quality improvement projects.
Preschool children's high‐frequency heart rate variability during low and high emotional challenge in relation to their self‐regulation
Authors: Clark Caron A. C. , Cardellini de Almeida Patricia , Joshi Keyoor 
Published: April 2024

AbstractHigh‐frequency heart rate variability (hf‐HRV) theoretically provides a biomarker for self‐regulation, although studies with young children offer mixed findings regarding the relevance of emotional demands in this link. We aimed to describe variation in children's hf‐HRV during tasks with relatively high and low emotional load and to determine the relation of hf‐HRV during these tasks to different behavioural measures of children's self‐regulation. Electrocardiograms were recorded in 80 3–5‐year‐olds (M = 57 months; 54% male, 47% female; 87% White, 8% mixed/other race, 2% African American/Black, 1% were Asian and 1% Hispanic/Latinx) whilst they completed a Go/No‐go task with low emotional load and an emotionally challenging Delay Frustration task. Mean hf‐HRV was similar across these tasks, although it increased during a between‐task rest interval. Accounting for age, gender and caregiver education, hf‐HRV during the Go/No‐go task correlated with task performance, whereas hf‐HRV during the emotional task correlated with caregiver‐reported regulation (Psuedo R
2 = 03–0.05). Greater hf‐HRV withdrawal during the tasks correlated with weaker Go/No performance and increased behavioural frustration (Psuedo R
2 = 0.08–0.13). Children's maintenance of hf‐HRV during emotional and cognitive challenges may support their effective self‐regulation.
Accurate diagnosis of dementia and Alzheimer's with deep network approach based on multi‐channel feature extraction and selection
Authors: Sertkaya Mehmet Emre , Ergen Burhan , Türkoğlu Muammer , Tonkal Özgür 
Published: April 2024

AbstractIn this article, we have proposed a multi‐stage in‐depth approach based on the improved VGGNet architecture for automatically and accurately diagnosing dementia and Alzheimer's disease. In this approach, first of all, the learned weights of the VGG16 architecture are frozen, and multichannel attributes are extracted from each pooling layer. Then, these attributes were given to the inputs of the attribute average pooling layers, and one‐dimensional attributes were produced using the flattened layer. Distinctive and effective attributes were selected from these deep attributes by the mRMR algorithm. Finally, the selected attributes are given to the input of the eight‐layer classification model, which includes the Fully connected, Relu, and softmax layers. A publicly available data set consisting of four classes and 6400 images was used to test the correctness of the proposed architecture. In addition, since the number of images belonging to the classes in this data set is unstable, data augmentation methods were used. As a result, a 98.6% accuracy score was produced with the developed architecture. These results show that the proposed architecture outperforms the original VGG16 and previous works.
Synthetic strategy for the production of electrically polarized polyvinylidene fluoride‐trifluoroethylene—co‐polymer osseo‐functionalized with hydroxyapatite scaffold
Authors: Swain Subhasmita , Lenka Rojaleen , Rautray Tapash 
Published: April 2024

AbstractThe physiological mechanism of bone tissue regeneration is intricately organized and involves several cell types, intracellular, and extracellular molecular signaling networks. To overcome the drawbacks of autografts and allografts, a number of synthetically produced scaffolds have been manufactured by integrating ceramics, polymers, and their hybrid‐composites. Considering the fact that natural bone is composed primarily of collagen and hydroxyapatite, ceramic‐polymer composite materials seem to be the most viable alternative to bone implants. Here, in this experimental study, copolymer PVDF‐TrFE has been amalgamated with HA ceramics to produce composite scaffolds as bone implants. In order to fabricate PVDF‐TrFE‐HA (polyvinylidene fluoride‐trifluoroethylene—hydroxyapatite) composite scaffolds, solvent casting‐particulate leaching technique was devised. Two scaffold specimens were produced, with different PVDF‐TrFE and HA molar ratios (70:30 and 50:50), and then electrically polarized to observe the subsequent polarization impact on the tissue growth and the suppression of bacterial cell proliferation. Both the specimens underwent characterization to analyze their biocompatibility and bactericidal activities. The bacterial culture of Pseudomonas aeruginosa (P. aeruginosa) and Staphylococcus aureus (S. aureus) bacteria on the composites was studied to understand the antibacterial characteristics. Moreover, MG63 cells cultured on these as‐formed composites provided information about osteogenesis. Improved osteogenesis and antibacterial efficacy were observed on both the composites. However, the composite with 70 wt% PVDF‐TrFE and 30 wt% HA showed a higher bactericidal effect as well as osteogenesis. It was found that PVDF‐TrFE‐HA‐based biomaterials have the potential for bone tissue engineering applications.
CircNRD1 elevates THAP domain containing 11 through sequestering microRNA‐421 to inhibit gastric cancer growth and tumorigenesis
Authors: Liu Anwen , Liang Jingcong , Wen Jianfeng 
Published: April 2024

AbstractWe explored the role and mechanism of circular RNAcircNRD1 in gastric cancer (GC) progression, aiming to identify new bio‐markers for the treatment and prognosis of GC patients. The RNA expression was examined by reverse transcription‐quantitative polymerase chain reaction. Cell proliferation, migration and invasion were analyzed by 3‐(4,5‐Dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT) assay, 5‐ethynyl‐2'‐deoxyuridine (EdU) incorporation assay, scratch assay and transwell assay. Western blot assay was conducted for protein expression measurement. Dual‐luciferase reporter, RNA immunoprecipitation, and RNA pull‐down assays were conducted to verify the interaction between microRNA‐421 (miR‐421) and circNRD1 or THAP domain containing 11 (THAP11). Xenograft tumor model was established to perform in vivo experiments. CircNRD1 was notably downregulated in GC tissues and cell lines. Additionally, decreased circNRD1 level was closely associated with advanced tumor stage and dismal prognosis in GC patients. CircNRD1 overexpression suppressed the proliferation and metastasis of GC cells. CircNRD1 acted as a molecular sponge for miR‐421 in GC cells, and the antitumor impacts of circNRD1 overexpression in GC cells could be alleviated by miR‐421 overexpression. miR‐421 directly targeted THAP11, and circNRD1 could up‐regulate THAP11 expression in GC cells through sponging miR‐421. THAP11 knockdown reversed circNRD1 overexpression‐induced tumor suppressing effects in GC cells. CircNRD1 overexpression significantly blocked tumor growth in vivo. CircNRD1 suppressed the proliferation and metastasis of GC cells in vitro and blocked tumor growth in vivo via modulating miR‐421/THAP11 axis.
Nephro‐protective effects of alpha‐lipoic acid in type I diabetes
Authors: Kushwaha Kriti , Mandal Debojyoti , Khurana Navneet , Gupta Jeena 
Published: April 2024

AbstractType 1 diabetes (T1D) is an insulin‐dependent autoimmune condition. Short chain fatty acids (SCFAs) are volatile fatty acids with 1–6 carbon atoms that influence glucose storage in the body and can reduce appetite, potentially decreasing T1D risk. Alpha‐lipoic acid (α‐LA), a type of SCFA, has previously been used to treat diabetic neuropathy and inflammation due to its antioxidant properties. This study aims to assess α‐LA's protective effects against T1D and associated kidney damage in rats induced with streptozotocin. Diabetic rats were treated with α‐LA orally for 15 days, resulting in improved blood glucose (56% decrease) and kidney function markers like blood urea nitrogen, creatinine and uric acid. α‐LA also showed significant antioxidant effects by decreasing LPO as well as improving activities of antioxidant enzymes like superoxide dismutase, catalase and glutathione‐S transferase and alleviated kidney damage caused by diabetes. Docking experiments suggest that α‐LA may regulate diabetes‐related changes at the epigenetic level through interactions with the SIRT1 protein, indicating its potential as a target for future antidiabetic drug development.
Comparison of muscle and fat parameters measured by ultrasonography and dual‐energy x‐ray absorptiometry between older palliative care patients with and without type 2 diabetes mellitus
Authors: Catikkas Nezahat Muge , Safer Vildan Binay , Bas Suleyman , Gunay Deniz Sevindik , Durak Ayfer , Utku Irem Kirac , Safer Umut 
Published: April 2024

AbstractBackground and AimsThere are limited data on the comparison of body compositions between diabetic and non‐diabetic patients. We aimed to compare the muscle mass and fat parameters measured by ultrasonography (USG) and dual‐energy x‐ray absorptiometry (DXA) between older palliative care patients with and without type 2 diabetes mellitus (DM).MethodsWe conducted a prospective, cross‐sectional study. We recorded the demographics, comorbidities, blood pressures, microvascular complications, pressure injuries, ambulation and nutritional status, and laboratory parameters. We measured the handgrip strength with a hand dynamometer and anthropometric parameters. We analyzed the subcutaneous fat thickness, muscle thickness (MT), and cross‐sectional area (CSA) of the rectus femoris (RF) and biceps brachii muscles by USG and the total and regional muscle mass and fat parameters by DXA. We performed a regression analysis to examine the independently associated factors of DM.ResultsWe included 55 patients (mean age: 79.0 ± 8.0 years, 56.4%: female). 43.6% had type 2 DM. The patients with DM had significantly higher glucose and HbA1c levels and lower RFMT and RFCSA values than the patients without DM (p < 0.01, for all). The RFMT was independently associated with DM after adjusting age, sex, and body mass index (Odds ratio = 0.735, 95% confidence interval = 0.565–0.956, p = 0.022).ConclusionOur study demonstrated that the RFMT might be associated with type 2 DM. This was the first study comparing the body compositions measured by USG and DXA between older diabetic and non‐diabetic palliative patients with a wide range of laboratory evaluations. Longitudinal, multi‐center studies are warranted to understand the underlying mechanisms.