bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epidemiology of breast carcinoma IV: Age and histologic tumor type
Authors: Rosen Paul Peter , Lesser Martin L. , Senie Ruby T. , Duthie Kathleen 
Published: February 2007

AbstractThe purpose of this study was to correlate major chronologic events known to have a bearing on the risk for developing breast carcinoma with histologic tumor type. Data were obtained for 1024 consecutively treated patients with the seven most common forms of mammary carcinoma. The age of occurrence of the following events was determined: menarche; first marriage; first pregnancy and first childbirth; last pregnancy and last childhood; diagnosis. The interval between each of these events and diagnosis of breast cancer was also calculated.Patients with medullary carcinoma had a significantly lower mean age at diagnosis than those with any of the other tumor types. Because of the lower mean age at diagnosis, medullary carcinoma patients were found to have significantly shorter intervals between age at diagnosis and the following: menarche, first pregnancy or first childbirth, and last pregnancy or last childbirth, Intervals between age at diagnosis and these other events were not significantly different among patients with other types of carcinoma. The ages of menarche, marriage, or pregnancy were not related independently to any tumor type. These data indicate that except for current age. the age of occurrence of major risk factors for developing breast cancer is unrelated to the histological type of tumor a patient develops.
Diamminodichloroplatinum combination chemotherapy in non‐oat cell carcinoma of the lung
Authors: Vincent Ronald G. , Lane Warren W , Raza Sabahat , Madajewicz Stefan 
Published: February 2007

AbstractA comparison is made between four different but similar approaches to the chemotherapy of 250 patients with nonoat cell bronchogenic carcinoma of the lung. Combination chemotherapy, particularly in regimen where platinum is included, provided no significant advantages over single agent chemotherapy. Side effects attributed to platinum tend to distract from any modest therapeutic gains achieved through its use. Responses rates were not significantly increased through use of platinum in the chemotherapy combination reported in this study.
Histologic changes seen in the hepatic parenchyma and in metastatic nodules following hepatic dearterialization
Authors: Paris Allen L. , Meissner William A. , McDermott William V. 
Published: February 2007

AbstractHepatic dearterialization was performed on four patients in an attempt to provide symptomatic relief from metastic carcinoma in the liver. Interruption of hepatic arterial blood supply causes necrosis in large metastatic tumor deposits, but very small nodules are unaffected by the procedure; this observation supports experimental studies on tumor angiogenesis factor. Interruption of hepatic arterial blood supply results in nonspecific ischemic changes to the hepatic parenchyma, which responds with small nests of regenerating liver cells. This finding appears to support the work of Plengvanit on revascularization of the liver after hepatic artery ligation.
Metastatic iodophilic carcinoma of thyroid to a hand bone
Authors: Horn Yoav 
Published: February 2007

AbstractA case of follicular carcinoma of the thyroid is presented with two unusual features: 1) metastatic tumor in a phalanx; and 2) all iodophilic metastases, making possible treatment with radioiodine. The possible mechanism of metastases to reach the systemic arterial circulation is discussed.
The role of initial modality in treatment of squamous cell carcinoma of the tongue
Authors: Razack Mohamed S. , Sako Kumao , Patel Jashbhai K. 
Published: February 2007

AbstractThis is a retrospective study in 279 patients, who were treated for squamous cell carcinoma of the tongue, to evaluate the role of initial modality on survival and recurrence pattern and the salvage rate of the second modality (surgery or radiation therapy) when the first one had failed.
Adjuvant chemoimmunotherapy stage i/ii malignant melanoma
Authors: Knost J. A. , Reynolds V. , Greco F. A. , Oldham R. K. 
Published: February 2007

AbstractSixty patients with Stage I or Stage II malignant melanoma were treated with wide local excision of the primary and dissection of the regional lymph nodes prior to being randomized to chemoimmunotherapy with DTIC plus intradermal BCG versus methyl‐CCNU plus intradermal BCG. For the 32 Stage I patients, there were no differences in survival between the two treatment groups. Survival was similar to a concomitant control group of 45 Stage I patients. For Stage II melanoma both chemoimmunotherapy groups had a significantly better survival than the 11 patients in the untreated control group. These results do not indicate that this form of chemoimmunotherapy is valuable in Stage I malignant melanoma but further trials are needed for patients with Stage II disease.
Carotid artery hemorrhage and ligation in head and neck cancer
Authors: Razack Mohamed S. , Sako Kumao 
Published: February 2007

AbstractDuring a 20‐year period, 77 patients who underwent ligation of the common or internal carotid artery were analyzed for the site, side of hemorrhage and/or ligation, with incidence of rebleed, previous treatment (surgery and/or radiation therapy), the type of incision utilized for resection, the incidence of preoperative and intraoperative hypotension and hemiplegia. The immediate mortality and subsequent follow‐up of the patients were also noted.
Metabolic acidosis in patients with the carcinoid syndrome: Treatment with parachlorophenylalanine
Authors: Feldman Jerome M. 
Published: February 2007

AbstractFour of 46 patients with carcinoid tumors and the carcinoid syndrome developed severe life‐threatening diarrhea. Although only 11% of the patients in this series had bronchial carcinoid tumors, three of the four patients with severe diarrhea had this type of tumor. Three of the patients with severe diarrhea developed metabolic acidosis while the fourth patient had severe hypokalemia. In the three patients in which it was used, parachlorophenylalanine, an inhibitor of serotonin synthesis, improved the life‐threatening diarrhea.
Results of the national soft‐tissue sarcoma registry
Authors: Mettlin Curtis , Priore Roger , Rao Uma , Gamble Delores , Lane Warren , Murphy Gerald P. 
Published: February 2007

AbstractOf 191 case reports submitted to the National Soft Tissue Sarcoma Registry, 131 qualified for inclusion. Fifty‐two percent were males; 80% were whites. Twenty‐one different histologies were assigned, with leiomyosarcoma most frequently represented. Localized disease was reported for 29% of patients. Surgery in combination with radiotherapy and/or chemotherapy was reported as the treatment for 45% of patients, and surgery only was reported for 31%. These data reflect increasing use of adjuvant therapy in the treatment of soft‐tissue sarcoma.
Primary liposarcoma of the lung: Report of a case
Authors: Sawamura Kenji , Hashimoto Takeshi , Nanjo Satoru , Nakamura Kenji , Iioka Sogo , Mori Takashi , Furuse Kiyoyuki , Shakudo Yozo 
Published: February 2007

AbstractWe reported one case of a primary liposarcoma of the lung which has been reported only in six cases to date worldwide, and we added some documented study. A 49‐year‐old female complained of exertional dyspnea with about 100 ml of hemoptysis. The chest X ray showed a coin lesion at the left upper field. After left pneumonectomy, the histological examination revealed liposarcoma of the lung. Six months after the operation, she died from severe dyspnea; the autopsy revealed the relapse of liposarcoma in the right lung, and no liposarcomas in other organs. This is the seventh case according to a worldwide review of the literature.
Current surgical management of in situ cancer of the female breast
Authors: Albert Samuel , Belle Steven , Eckert Dorothy , Swanson G. Marie 
Published: February 2007

AbstractSurgical procedures for breast cancer were compared in 468 cases with insitu and 4,967 cases with invasive lesions. The cases were obtained from the Michigan Cancer Foundation Registry, a Surveillance, Epidemiology, and End Results (SEER) participant, and were incident‐resident cases diagnosed from 1973–1978. For single, primary in situ or invasive cancer, the preferred mastectomy was modified radical. Partial and simple resections were used more often than radical procedures for non‐inflitrating, especially lobular lesions. For cases with bilateral primaries, with at least one in situ, the mastectomy of choice was the simple procedure for the in situ malignancy and modified radical for the invasive cancer. The change in preferred surgery for in situ lesions, from modified radical to simple mastectomy, was not due to any change in strategy for treatment of bilateral invasive disease, which remained modified radical resection.
Malignant chondroid syringoma: A clinicopathological study and a collective review
Authors: Gupta S. , Kumar A. , Padmanabhan A. , Khanna S. 
Published: February 2007

AbstractMalignant chondroid syringomas are extremely rare adnexal tumors of the skin, so far reported only in six cases, all females. The present case occurred in a male. There were multiple nodules in the left lower limb of long duration. The malignant nature of the tumor was evident from repeated recurrences after excision of the nodules. The excised nodules showed cellular pleomorphism and mitoses. Lack of response to radiotherapy and chemotherapy led to mid‐thigh amputation.
Human colorectal carcinoma: Patterns of sensitivity to chemotherapeutic agents in the human tumor stem cell assay
Authors: Agrez Michael V. , Kovach John S. , Beart Robert W. , Rubin Joseph , Moertel Charles G. , Lieber Michael M. 
Published: February 2007

AbstractThe human tumor stem cell assay (HTSCA) was applied to 103 primary and metastatic colorectal carcinomas. Thirty‐four carcinomas could not be evaluated for colony formation (clonogenicity) because of microbial contamination. Of the remaining 69 carcinomas, 18 (26%) demonstrated clonal growth in vitro. Colony formation did not correlate with the clini‐copathologic stage of the tumor, the histological grade of the tumor, the method used to disperse the solid tumors into single cells (mechanical or enzymatic), or cell viability (exclusion of trypan‐blue) prior to plating. The in vitro chemotherapy sensitivity data of the 18 tumors which formed colonies indicated that most tumors were generally resistant to chemotherapeutic drugs and that a few tumors were sensitive to multiple agents. Use of the human tumor stem cell assay may facilitate an individualized approach to clinical chemotherapy of colorectal carcinoma for certain patients.
Treatment and prognosis of thymoma: A review of 25 cases
Authors: Appelqvist P. , Kostiainen S. , Franssila K. , Mattila S. , Gröhn P. 
Published: February 2007

AbstractExperience of 25 patients with thymoma is reported. Based on the presence or absence of gross invasion 17 tumors were regarded as benign, 8 as malignant. All patients were operated on. Twenty‐two had a complete excision, 2 a palliative excision, and 1 a biopsy only. Five patients received post‐operative radiotherapy and 2 patients were given cytotoxic chemotherapy. None of the 17 patients with a benign thymoma had a recurrence or death due to thymoma during the follow‐up. The five‐ and ten‐year survival rates for malignant thymoma were 50% and 17%, respectively. Excision is the treatment of choice for all thymomas, since the prognosis for benign tumor is excellent and the malignancy can only be determined at exploration. Post‐operative radiotherapy seems to be indicated in malignant thymoma. Myasthenia gravis and histologic features of thymoma have some value in predicting prognosis.
A critical review of immunotherapy of disseminated renal adenocarcinoma
Authors: Montie James E. , Bukowski Ronald M. , James Robert E. , Straffon Ralph A. , Stewart Bruce H. 
Published: February 2007

AbstractSixty patients with renal adenocarcinoma have been treated with five different immunotherapy trials consisting of 1) Transfer Factor (TF), 2) TF and Bacillus Calmette‐Guerin (BCG), 3) TF, BCG, Chloroethyl‐cyclohexy‐nitrosurea (CCNU) and megestrol acetate (Megase), 4) BCG, CCNU, and Megase, or 5) BCG. Using strict response criterea for measurable disease, objective responses were seen in 14–22% of cases. While this nonspecific immunotherapy of renal adenocarcinoma has been associated with documented regression of metastases, response rates are similar to that obtained with hormonal therapy alone. Objective responses support the concept of further trials in this disease with more sophisticated immunotherapy.
Amylase‐producing lung cancer
Authors: Martin Pamela C. , Sarma Deba P. 
Published: February 2007

AbstractA bronchioloalveolar carcinoma of lung associated with hyper‐amylasemia occurring in a 40‐year‐old woman is described. Another 13 cases of such a tumor from the English literature are reviewed. A majority of the lung tumors associated with hyperamylasemia were adenocarcinomas. When the amylase isoenzymes were determined, the amylase appeared to be salivary‐gland type (S‐type). Electron microscopic studies had revealed membrane‐bound electron‐dense granules within the tumor cells.
Localized large cell lymphoma cured by simple excision
Authors: Ree H. J. , Crowley James P. , Micolonghi Thomas S. 
Published: February 2007

AbstractDiffuse large cell lymphoma is frequently localized at the time of presentation, but the aggressive natural history of the disease in most patients has suggested that extensive and intensive radiation and/or chemotherapy is necessary to control this disease. We describe a patient who has remained free of disease for 20 years after simple excision of a diffuse large cell lymphoma localized to the right cervical region. Review of the biopsy material showed characteristic histologic features suggestive of an orderly growth pattern of tumor cells as well as sclerosis. The clinical course of this patient after minimal therapy emphasizes the possibility of long survival with localized large cell lymphoma and suggests that the characteristic morphologic features observed in this case should be sought in other cases, since it may imply a favorable prognosis.
Treatment of advanced gastric cancer with 5‐fluorouracil versus mitomycin C
Authors: Gupta Saroj 
Published: February 2007

AbstractThirty‐eight patients of advanced adenocarcinoma of the stomach were randomly administered intensive courses; of either 5‐FU or mitomycin C by intravenous route, The 5‐FU administration resulted in a slightly better response than mitomycin C, although the toxic effects of the two drugs were more or less the same. The selection of drug regime in the present study has been based on cost, availability, potential toxicity, and minimal alteration of the patients' life style.
Colorectal carcinoma: Evaluation of histologic grade and factors influencing prognosis
Authors: Chung C. K. , Zaino Richard J. , Stryker John A. 
Published: February 2007

AbstractWe analyzed 246 patients with adenocarcinoma of colorectum treated with “curative” surgery alone. In reviewing these cases it is apparent that patients with poorly differentiated tumor (Grade 3) have an increased likelihood of deep invasion of tumor through the bowel wall and lymph node metastases compared to well (Grade 1) or moderately differentiated tumor (Grade 2). Poor differentiation of the tumor, deep penetration through the bowel wall and lymph node metastases appear to represent unfavorable prognostic indices in patients operated upon. Age, sex, size of primary tumor, and large bowel site of tumor origin were unrelated to the prognosis.Compared to Grade 1 and 2 tumors, patients with Grade 3 lesions had more local recurrences and/or distant metastases. These findings suggest that histologic grading is an important adjunct to the clinical evaluation and treatment planning of patients with colorectal carcinoma.
Patterns of breast cancer detection in the United States
Authors: Nemoto T. , Natarajan N. , Smart C. R. , Mettlin C. , Murphy G. P. 
Published: February 2007

AbstractThe American College of Surgeons Commission on Cancer Short‐term Survey of Breast Cancer in 12,315 patients showed that 73% of malignant tumors are found by patients, 23% by physicians, and 4% by mammography. It also indicated that younger women are more likely to discover tumors than older women, and that mammography is more likely to detect small tumors with negative axillary nodes. The effectiveness of mammography is most evident in women 50 to 74 years of age, although in women 45 to 49 years, the frequency of tumors detected by mammography nearly equals that for other groups. In black women, mammography may not be currently fully utilized. Analysis of the survey data would indicate that patients appear to demonstrate adequate skill in detecting tumors, as compared to physicians. A delay in diagnosis of longer than 3 months is associated with larger tumors and increased likelihood of axillary metastasis.
A feasibility study in the development of biological markers for ovarian cancer
Authors: Waalkes T. Phillip , Rosenshein Neil B. , Shaper Joel H. , Ettinger David S. , Woo Kwang B. , Paone Joseph F. , Gehrke Charles W. 
Published: February 2007

AbstractAs a primary feasibility study for the selection of biomarkers for more extended clinical evaluation, 17 potential biomarker candidates were measured in the body fluids of patients with ovarian carcinoma. For comparative purposes, patients were staged and separated into three groups: those considered completely free of disease, those with residual but minimal tumor, and those with advanced disease. Individual markers included plasma carcinoembryonic antigen, serum human chorionic gonadotrophin, urinary β‐aminoisobutyric acid, serum UDP‐galactosyltransferase, and urinary hydroxyproline. Structurally related groups of biomarkers included six modified nucleosides and three polyamines analyzed in urine, and three serum protein‐bound neutral carbohydrates. The respective chromatographic methods developed for these latter biochemical materials enabled all the individual compounds in each group to be quantitated simultaneously in one analytical run. The general frequency and degree of elevation for the total number of biomarkers was directly proportional to increasing tumor burden with specific exceptions, human chorionic gonadotrophin and β‐aminoisobutyric acid. Galactosyl‐transferase was the most frequently elevated in the limited disease categories. Several of the biomarkers were elevated in the majority of patients with advanced disease and appeared potentially superior to carcinoembryonic antigen or human chorionic gonadotrophin.
Melanoma arising under the nail
Authors: Papachristou Dimitri N. , Fortner Joseph C. 
Published: February 2007

AbstractSubungual melanoma, a rare and easily misdiagnosed neoplasm, affected 52 patients. The lesion usually appeared as a dark spot under the nail, causing its destruction at a later stage. Diagnosis was missed by primary care physicians in 42% of the cases. Management in the hospital consisted of amputation of the involved finger or toe with or without regional node dissection. The study indicated that proper amputation should be at the tarsometatarsal or the carpometacarpal level. It also showed the node dissection should best be performed at the time of amputation, regardless of whether the nodes are clinically involved or not. Besides nodal metastasis, prognosis is adversely affected by nail destruction caused by the tumor. Subungual melanomas of the fingers have a better prognosis.
Leiomyosarcoma of the inferior vena cava
Authors: Patel J. K. , Englander L. S. 
Published: February 2007

AbstractA case of leiomyosarcoma of the inferior vena cava of a 46‐year‐old man is presented, and review of 51 cases of this type of malignant tumor is made. The biological behavior of this tumor and various treatment modalities are discussed.
High‐flow isolation perfusion of the rat hind limb in vivo
Authors: Benckhuysen C. , Van Dijk W. J. , Van Hoff S. C. T 
Published: February 2007

AbstractAn in vivo model for perfusion chemotherapy of the rat hind limb is described in which perfusion at a predetermined flow rate of up to 4 ml·min−1can be rapidly established in a tourniquet‐isolated limb. Standard additions to the semisynthetic perfusion medium included glucose, insulin, and lactate from fresh human erythrocytes. Arteriovenous differences in oxygen content revealed a gradual increase with time of the rate of oxygen consumption until a plateau phase was reached. The plateau rates of oxygen consumption, and of utilization of lactate and of acetoacetate, when supplied, were significantly higher at 4 ml flow·min−1than at 1.2 ml·min−1. When perfusion was performed at 4 ml·min−1, and suitable metabolic substrates were supplied, the rate of oxygen consumption at the plateau level was apparently equal to the estimated in vivo rate.
Rhabdomyoma of the abdominal wall: Resection based upon computerized tomosraohic characteristics
Authors: Giuseffi Steven A. , Malangoni Mark A. , Madiedo Gonzalo 
Published: February 2007

AbstractA unique report of an abdominal wall rhabdomyoma is presented. The rarity of this tumor may lead to confusion with a malignant neoplasm. Computerized axial tomography localized the tumor to a specific muscle group and demonstrated absence of invasion into surrounding tissues. Computerized tomography is valuable in the assessment of abdominal wall tumors and provides useful information in planning an operative approach.
Multimodality therapy of stage III adenocarcinoma of the breast
Authors: Bitran J. D. , Desser R. K. , Schifeling D. , Shapiro C. M. , Kozloff M. F. , Robin E. , Recant W. , Michel A. , Rochman H. , Billings A. A. 
Published: February 2007

AbstractThe results of a pilot multimodality program (surgery + radiotherapy + chemotherapy) are reported in 34 women with advanced stage III and IV adenocarcinoma of the breast. The median relapse‐free survival for all patients was 24 months, with 74% of the premenopausal patients and 37% of the postmenopausal alive at five years (P = 0.18). The relapse rate was significantly lower in premenopausal patients when compared to the postmenopausal subgroup. Estrogen receptor status was not predictive for relapse or survival.
Prolactin‐secreting tumors
Authors: Ozarda Ahsen T. 
Published: February 2007

AbstractA case of galactorrhea induced by hyperprolactinemia has been reported. This patient had bronchogenic carcinoma, undifferentiated, spindle‐cell‐type, and underwent a pneumonectomy followed by postoperative irradiation of the mediastinum. The initial surgical resection, followed by irradiation, returned the abnormal levels of prolactin secretion to normal. Although subsequent determinations could not be made, this case supports evidence from earlier reports that galactorrhea‐induced hyperprolactinemia may occur concomitantly as a paraneoplastic syndrome with this rare form of carcinoma.
Heterochromia iridis and Homer's syndrome due to paravertebral neurilemmoma
Authors: Saved Atef K. , Miller Barbara A. , Lack Ernest E. , Sallan Stephen E. , Levey Raphael H. 
Published: February 2007

AbstractA case of heterochromia iridis and Horner's syndrome is reported in a 7‐year old girl with paravertebral neurilemmoma. These clinical findings can be useful in the early diagnosis of mediastinal tumors in the paravertebral axis. While typically associated with neuroblastoma, these findings can be due to tumors which are inately benign — in this case neurilemmoma. The mechanism for heterochromia is briefly discussed.