bluuebunny/crossref_metadata_2025_split huggingface dataset:
Growth Stimulation of Non–Small Cell Lung Cancer Cell Lines by Antibody against Epidermal Growth Factor Receptor Promoting Formation of ErbB2/ErbB3 Heterodimers
Authors: Maegawa Mari , Takeuchi Kenji , Funakoshi Eishi , Kawasaki Katsumi , Nishio Kazuto , Shimizu Nobuyoshi , Ito Fumiaki 
Published: April 2007

Abstract
Antibodies are the most rapidly expanding class of human therapeutics, including their use in cancer therapy. Monoclonal antibodies (mAb) against epidermal growth factor (EGF) receptor (EGFR) generated for cancer therapy block the binding of ligand to various EGFR-expressing human cancer cell lines and abolish ligand-dependent cell proliferation. In this study, we show that our mAb against EGFRs, designated as B4G7, exhibited a growth-stimulatory effect on various human cancer cell lines including PC-14, a non–small cell lung cancer cell line; although EGF exerted no growth-stimulatory activity toward these cell lines. Tyrosine phosphorylation of EGFRs occurred after treatment of PC-14 cells with B4G7 mAb, and it was completely inhibited by AG1478, a specific inhibitor of EGFR tyrosine kinase. However, this inhibitor did not affect the B4G7-stimulated cell growth, indicating that the growth stimulation by B4G7 mAb seems to be independent of the activation of EGFR tyrosine kinase. Immunoprecipitation with anti-ErbB3 antibody revealed that B4G7, but not EGF, stimulated heterodimerization between ErbB2 and ErbB3. ErbB3 was tyrosine phosphorylated in the presence of B4G7 but not in the presence of EGF. Further, the phosphorylation and B4G7-induced increase in cell growth were inhibited by AG825, a specific inhibitor of ErbB2. These results show that the ErbB2/ErbB3 dimer functions to promote cell growth in B4G7-treated cells. Changes in receptor-receptor interactions between ErbB family members after inhibition of one of its members are of potential importance in optimizing current EGFR family–directed therapies for cancer. (Mol Cancer Res 2007;5(4):393–401)
Response of the Middle Atmosphere to CO2 Doubling: Results from the Canadian Middle Atmosphere Model
Authors: Fomichev V. I. , Jonsson A. I. , de Grandpré J. , Beagley S. R. , McLandress C. , Semeniuk K. , Shepherd T. G. 
Published: April 2007

Abstract
The Canadian Middle Atmosphere Model (CMAM) has been used to examine the middle atmosphere response to CO2 doubling. The radiative-photochemical response induced by doubling CO2 alone and the response produced by changes in prescribed SSTs are found to be approximately additive, with the former effect dominating throughout the middle atmosphere. The paper discusses the overall response, with emphasis on the effects of SST changes, which allow a tropospheric response to the CO2 forcing. The overall response is a cooling of the middle atmosphere accompanied by significant increases in the ozone and water vapor abundances. The ozone radiative feedback occurs through both an increase in solar heating and a decrease in infrared cooling, with the latter accounting for up to 15% of the total effect. Changes in global mean water vapor cooling are negligible above ∼30 hPa. Near the polar summer mesopause, the temperature response is weak and not statistically significant. The main effects of SST changes are a warmer troposphere, a warmer and higher tropopause, cell-like structures of heating and cooling at low and middlelatitudes in the middle atmosphere, warming in the summer mesosphere, water vapor increase throughout the domain, and O3 decrease in the lower tropical stratosphere. No noticeable change in upward-propagating planetary wave activity in the extratropical winter–spring stratosphere and no significant temperature response in the polar winter–spring stratosphere have been detected. Increased upwelling in the tropical stratosphere has been found to be linked to changed wave driving at low latitudes.
North American Droughts of the Last Millennium from a Gridded Network of Tree-Ring Data
Authors: Herweijer Celine , Seager Richard , Cook Edward R. , Emile-Geay Julien 
Published: April 2007

Abstract
Drought is the most economically expensive recurring natural disaster to strike North America in modern times. Recently available gridded drought reconstructions have been developed for most of North America from a network of drought-sensitive tree-ring chronologies, many of which span the last 1000 yr. These reconstructions enable the authors to put the famous droughts of the instrumental record (i.e., the 1930s Dust Bowl and the 1950s Southwest droughts) into the context of 1000 yr of natural drought variability on the continent. We can now, with this remarkable new record, examine the severity, persistence, spatial signatures, and frequencies of drought variability over the past milllennium, and how these have changed with time.
The gridded drought reconstructions reveal the existence of successive “megadroughts,” unprecedented in persistence (20–40 yr), yet similar in year-to-year severity and spatial distribution to the major droughts experienced in today’s North America. These megadroughts occurred during a 400-yr-long period in the early to middle second millennium a.d., with a climate varying as today’s, but around a drier mean. The implication is that the mechanism forcing persistent drought in the West and the Plains in the instrumental era is analagous to that underlying the megadroughts of the medieval period. The leading spatial mode of drought variability in the recontructions resembles the North American ENSO pattern: widespread drought across the United States, centered on the Southwest, with a hint of the opposite phase in the Pacific Northwest.
Recently, climate models forced by the observed history of tropical Pacific SSTs have been able to successfully simulate all of the major North American droughts of the last 150 yr. In each case, cool “La Niña–like” conditions in the tropical Pacific are consistent with North American drought. With ENSO showing a pronounced signal in the gridded drought recontructions of the last millennium, both in terms of its link to the leading spatial mode, and the leading time scales of drought variability (revealed by multitaper spectral analysis and wavelet analysis), it is postulated that, as for the modern day, the medieval megadroughts were forced by protracted La Niña–like tropical Pacific SSTs. Further evidence for this comes from the global hydroclimatic “footprint” of the medieval era revealed by existing paleoclimatic archives from the tropical Pacific and ENSO-sensitive tropical and extratropical land regions. In general, this global pattern matches that observed for modern-day persistent North American drought, whereby a La Niña–like tropical Pacific is accompanied by hemispheric, and in the midlatitudes, zonal, symmetry of hydroclimatic anomalies.
Homogenization of Radiosonde Temperature Time Series Using Innovation Statistics
Authors: Haimberger Leopold 
Published: April 2007

Abstract
Radiosonde temperature records contain valuable information for climate change research from the 1940s onward. Since they are affected by numerous artificial shifts, time series homogenization efforts are required. This paper introduces a new technique that uses time series of temperature differences between the original radiosonde observations (obs) and background forecasts (bg) of an atmospheric climate data assimilation system for homogenization.
These obs − bg differences, the “innovations,” are a by-product of the data assimilation process. They have been saved during the 40-yr ECMWF Re-Analysis (ERA-40) and are now available for each assimilated radiosonde record back to 1958. It is demonstrated that inhomogeneities in the obs time series due to changes in instrumentation can be automatically detected and adjusted using daily time series of innovations at 0000 and 1200 UTC.
The innovations not only reveal problems of the radiosonde records but also of the data assimilation system. Although ERA-40 used a frozen data assimilation system, the time series of the bg contains some breaks as well, mainly due to changes in the satellite observing system. It has been necessary to adjust the global mean bg temperatures before the radiosonde homogenization.
After this step, homogeneity adjustments, which can be added to existing raw radiosonde observations, have been calculated for 1184 radiosonde records. The spatiotemporal consistency of the global radiosonde dataset is improved by these adjustments and spuriously large day–night differences are removed. After homogenization the climatologies of the time series from certain radiosonde types have been adjusted. This step reduces temporally constant biases, which are detrimental for reanalysis purposes. Therefore the adjustments applied should yield an improved radiosonde dataset that is suitable for climate analysis and particularly useful as input for future climate data assimilation efforts. The focus of this paper relies on the lower stratosphere and on the internal consistency of the homogenized radiosonde dataset. Implications for global mean upper-air temperature trends are touched upon only briefly.
Assessing a Satellite-Era Perspective of the Global Water Cycle
Authors: Schlosser C. Adam , Houser Paul R. 
Published: April 2007

Abstract
The capability of a global data compilation, largely satellite based, is assessed to depict the global atmospheric water cycle’s mean state and variability. Monthly global precipitation estimates from the Global Precipitation Climatology Project (GPCP) and the Climate Prediction Center (CPC) Merged Analysis of Precipitation (CMAP) span from 1979 to 1999. Monthly global Special Sensor Microwave Imager (SSM/I)-based bulk aerodynamic ocean evaporation estimates span from June 1987 to December 1999. Global terrestrial evapotranspiration rates are estimated over a multidecade period (1975–99) using a global land model simulation forced by bias-corrected reanalysis data. Monthly total precipitable water (TPW) from the NASA Global Water Vapor Project (NVAP) spans from 1988 to 1999.
The averaged annual global precipitation (P) and evaporation (E) estimates are out of balance by 5% or 24 000 (metric) gigatons (Gton) of water, which exceeds the uncertainty of global mean annual precipitation (∼±1%). For any given year, the annual flux imbalance can be on the order of 10% (48 000 Gton of water). However, observed global TPW interannual variations suggest a water flux imbalance on the order of 0.01% (48 Gton of water)—a finding consistent with a general circulation model (GCM) simulation. Variations in observationally based global P and E rates show weak monthly and interannual consistency, and depending on the choice of ocean evaporation data, the mean annual cycle of global E − P can be up to 5 times larger to that of TPW. The global ocean annual evaporation rates have as much as a ∼1% yr−1 increase during the period analyzed (1988–99), which is consistent in sign with most transient CO2 GCM simulations, but at least an order of magnitude larger. The ocean evaporation trends are driven by trends in SSM/I-retrieved near-surface atmospheric humidity and wind speed, and the largest year-to-year changes are coincident with transitions in the SSM/I fleet.
In light of (potential) global water cycle changes in GCM projections, the ability to consistently detect or verify these changes in nature rests upon one or more of the following: quantification of global evaporation uncertainty, at least a twofold improvement in consistency between the observationally based global precipitation and evaporation variations, a two order of magnitude rectification between annual variations of E − P and precipitable water as well as substantial improvements in the consistency of their seasonal cycles, a critical reevaluation of intersatellite calibration for the relevant geophysical quantities used for ocean evaporation estimates, and the continuation of a dedicated calibration in this regard for future satellite transitions.
The Impacts of Climate Change on Autumn North Atlantic Midlatitude Cyclones
Authors: Jiang Jing , Perrie William 
Published: April 2007

Abstract
This study explores how midlatitude extratropical cyclone intensities, frequencies, and tracks can be modified under warming-induced conditions due to enhanced greenhouse gas (GHG) concentrations. Simulations were performed with the Canadian mesoscale compressible community (MC2) model driven by control and high CO2 climate estimates from the Canadian Climate Centre model, the Second Generation Coupled Global Climate Model (CGCM2). CGCM2 simulations have effective CO2 concentration forcing, following the Intergovernmental Panel on Climate Change (IPCC) IS92a scenario conditions, which define a near doubling of CO2 concentrations by 2050 compared to the 1980s. The control and high CO2 conditions were obtained from years 1975–94 and 2040–59 of CGCM2 simulations. For the northwest Atlantic, the CO2-induced warming for this period (2040–59) varies from ∼1°–2°C in the subtropics, near the main development region for Atlantic hurricanes, to ∼1°C in the north. In simulations of northwest Atlantic storms, the net impact of this enhanced CO2 scenario is to cause storms to increase in radius, with marginal tendencies to become more severe and to propagate faster (although not statistically significant), and for the mean storm tracks to shift slightly poleward.
Characterization of the Interannual and Intraseasonal Variability of West African Vegetation between 1982 and 2002 by Means of NOAA AVHRR NDVI Data
Authors: Philippon N. , Jarlan L. , Martiny N. , Camberlin P. , Mougin E. 
Published: April 2007

AbstractThe interannual and intraseasonal variability of West African vegetation over the period 1982–2002 is studied using the normalized difference vegetation index (NDVI) from the Advanced Very High Resolution Radiometer (AVHRR).The novel independent component analysis (ICA) technique is applied to extract the main modes of the interannual variability of the vegetation, among which two modes are worth describing. The first component (IC1) describes NDVI variability over the Sahel from August to October. A strong photosynthetic activity over the Sahel is related to above-normal convection and rainfall within the intertropical convergence zone (ITCZ) in summertime and is partly associated with colder (warmer) SST in the eastern tropical Pacific (the Mediterranean). The second component (IC2) depicts a dipole pattern between the Sahelian and Guinean regions during the northern summer followed by a southward-propagating signal from October to December. It is associated with a north–south dipole in convection and rainfall induced by variations in the latitudinal location of the ITCZ as a response to the occurrence of the tropical Atlantic dipole.The analysis of the intraseasonal variability of the Sahelian vegetation relies on the analysis of the seasonal marches and their main phenological stages. Green-up usually starts in early July and shows a very low year-to-year variability, while senescence ends by mid-November and is prone to larger interannual variability. Six types of vegetative seasonal marches are discriminated according to variations in the timing of phenological stages as well as in the greening intensity. These types appear to be strongly dependent on rainfall distribution and amount, particularly those recorded in late August. Finally, year-to-year memory effects are highlighted: NDVI recorded during the green-up phase in year j appears to be strongly related to the maximum NDVI value recorded at year j − 1.
Impact of Tropical Easterly Waves on the North American Monsoon
Authors: Adams Jennifer L. , Stensrud David J. 
Published: April 2007

Abstract
The North American monsoon (NAM) is a prominent summertime feature over northwestern Mexico and the southwestern United States. It is characterized by a distinct shift in midlevel winds from westerly to easterly as well as a sharp, marked increase in rainfall. This maximum in rainfall accounts for 60%–80% of the annual precipitation in northwestern Mexico and nearly 40% of the yearly rainfall over the southwestern United States. Gulf surges, or coastally trapped disturbances that occur over the Gulf of California, are important mechanisms in supplying the necessary moisture for the monsoon and are hypothesized in previous studies to be initiated by the passage of a tropical easterly wave (TEW). Since the actual number of TEWs varies from year to year, it is possible that TEWs are responsible for producing some of the interannual variability in the moisture flux and rainfall seen in the NAM.
To explore the impact of TEWs on the NAM, four 1-month periods are chosen for study that represent a reasonable variability in TEW activity. Two continuous month-long simulations are produced for each of the selected months using the Pennsylvania State University–National Center for Atmospheric Research Mesoscale Model. One simulation is a control run that uses the complete boundary condition data, whereas a harmonic analysis is used to remove TEWs with periods of approximately 3.5 to 7.5 days from the model boundary conditions in the second simulation. These simulations with and without TEWs in the boundary conditions are compared to determine the impact of the waves on the NAM. Fields such as meridional moisture flux, rainfall totals, and surge occurrences are examined to define similarities and differences between the model runs. Results suggest that the removal of TEWs not only reduces the strength of gulf surges, but also rearranges rainfall over the monsoon region. Results further suggest that TEWs influence rainfall over the Southern Plains of the United States, with TEWs leading to less rainfall in this region. While these results are only suggestive, since rainfall is the most difficult model forecast parameter, it may be that TEWs alone can explain part of the inverse relationship between NAM and Southern Plains rainfall.
Exactly Sparse Extended Information Filters for Feature-based SLAM
Authors: Walter Matthew R. , Eustice Ryan M. , Leonard John J. 
Published: April 2007

Recent research concerning the Gaussian canonical form for Simultaneous Localization and Mapping (SLAM) has given rise to a handful of algorithms that attempt to solve the SLAM scalability problem for arbitrarily large environments. One such estimator that has received due attention is the Sparse Extended Information Filter (SEIF) proposed by Thrun et al., which is reported to be nearly constant time, irrespective of the size of the map. The key to the SEIF's scalability is to prune weak links in what is a dense information (inverse covariance) matrix to achieve a sparse approximation that allows for efficient, scalable SLAM. We demonstrate that the SEIF sparsification strategy yields error estimates that are overconfident when expressed in the global reference frame, while empirical results show that relative map consistency is maintained. In this paper, we propose an alternative scalable estimator based on an information form that maintains sparsity while preserving consistency. The paper describes a method for controlling the population of the information matrix, whereby we track a modified version of the SLAM posterior, essentially by ignoring a small fraction of temporal measurements. In this manner, the Exactly Sparse Extended Information Filter (ESEIF) performs inference over a model that is conservative relative to the standard Gaussian distribution. We compare our algorithm to the SEIF and standard EKF both in simulation as well as on two nonlinear datasets. The results convincingly show that our method yields conservative estimates for the robot pose and map that are nearly identical to those of the EKF.
Comparison of Bioabsorbable Pins and Nails in the Fixation of Adult Osteochondritis Dissecans Fragments of the Knee
Authors: Weckström Maria , Parviainen Mickael , Kiuru Martti J. , Mattila Ville M. , Pihlajamäki Harri K. 
Published: April 2007

Background The optimal device for the fixation of osteochondritis dissecans fragments of the knee remains controversial and lacks long-term results. Purpose To review a group of young adults with osteochondritis dissecans of the knee treated with arthroscopic fixation of the fragment using bioabsorbable pins and nails and to examine the medium-term outcome of the fixation via magnetic resonance imaging and clinical evaluation. Study Design Cohort study; Level of evidence, 3. Methods Twenty-eight patients (30 knees) with osteochondritis dissecans of the knee were treated with arthroscopic fixation using bioabsorbable, self-reinforced poly-L-lactide pins and nails. All patients were young adult males with closed physes. The average follow-up time was 5.4 years (range, 3-12). At follow-up, magnetic resonance imaging studies were used to evaluate subchondral bone healing, and the outcome was evaluated by the Kujala score. Results The functional results were excellent or good for 73% of the patients in the nail group versus 35% in the pin group. The lesions treated were large, with an average size of 447 mm2, affecting the weightbearing area in the majority of the patients. On magnetic resonance imaging, incomplete bone consolidation was predominant in the pin group. Conclusions Arthroscopic fixation with bioabsorbable nails seems to be a suitable method of repair for osteochondritis dissecans of the adult knee and appears to be superior to arthroscopic fixation with bioabsorbable pins.
Differences in 3-Dimensional Shoulder Kinematics between Persons with Multidirectional Instability and Asymptomatic Controls
Authors: Ogston Jena B. , Ludewig Paula M. 
Published: April 2007

Background Evidence that persons with multidirectional instability (MDI) of the shoulder have abnormal shoulder kinematics is limited. A kinematic description of scapulothoracic and glenohumeral motion can assist both conservative and surgical rehabilitative programs. Hypothesis Persons with MDI of the shoulder demonstrate increased anterior and inferior glenohumeral translation and decreased scapular upward rotation and increased scapular internal rotation compared with age-matched and gender-matched asymptomatic controls. Study Design Controlled laboratory study. Methods Sixty-two subjects were recruited from an outpatient orthopaedic clinic. Subjects with MDI were matched according to age, gender, and hand dominance to asymptomatic controls. An electromagnetic motion capture system evaluated the 3-dimensional position of the trunk, scapula, and humerus during frontal and scapular plane elevation. A repeated measures analysis of variance evaluated joint positions and glenohumeral translations during 4 phases of elevation (0°-30°, 31°-60°, 61°-90°, and 91°-120°). Results When averaged across the 4 phases of elevation, persons with MDI demonstrated a significant decrease in scapular upward rotation in scapular plane abduction (8°, P = .006) and abduction (5.8°, P = .016) and increased internal rotation during scapular plane abduction (12.2°, P = .03). Alterations in glenohumeral translations in the MDI group did not reach statistical significance (P = .54-.71). Conclusion Abnormal scapular kinematics are seen in the MDI shoulder, highlighting the importance of incorporating scapular positioning and stability exercises during rehabilitation. Additional study is warranted concerning the efficacy of various rehabilitation programs, and also both surgical and nonsurgical interventions in this population.