bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Peganum harmala seeds extract on the hepatic tissue structure and fetus of mice
Authors: Samira Musa Sasi  , Al ghoul Nagia , Awayn Nuri , El ghoul Ahmed , Prastiya Ragil 
Published: March 2024

Peganum harmala is one of the most used plants for the treatment of many diseases. Its effective compounds have pharmaceutical and medicinal properties. This study aims to determine the effect of aqueous extract of harmala plant seeds on body and liver weight, aspartate aminotransferase (AST), alanine transaminase (ALT), and the histological structure of liver of mice, as well as the size of the fetuses sired by treated mice. Sixteen adult male mice were divided into two groups of eight. The first group (control) was given distilled water orally, while the second group received the aqueous extract of harmala seeds at a dose of 300 mg/kg bw for three weeks. three untreated females were housed with one treated male for mating. At the end of the treatment, six male mice of each group were weighed and killed. Liver was extracted, weighed and its enzymes were measured. Also, sections of the liver were prepared for histological examination. The results showed a decrease in the body weight of the treated mice and a significant increase in the average weight of the fetuses compared with the control group, as well as marked changes in the hepatic tissue structure. There was no impact of the extract on fetal body length, liver weight and hepatic enzymes (AST and ALT) of treated mice. Further studies should be conducted to determine a safe dose that does not affect any organ in the body, so that it can be used for the treatment of many diseases.
Optimizing Power Grid Stability with Enhanced Circuit Breaker Maintenance
Authors: Cahyo Chandra Darmawan Dwi , Ayuni Shazana Dhiya 
Published: March 2024

This study aims to evaluate the effectiveness of maintenance techniques on 20 kV Power Circuit Breakers (PMTs) using the Research and Development (R&D) method. Key performance variables assessed included contact resistance, PMT synchronism, and insulation resistance. Findings revealed that contact resistance for all phases was below 100 µΩ, indicating optimal connectivity. Synchronism testing showed time differences of 0.7 ms during opening and 1.05 ms during closing, both within acceptable limits. Furthermore, insulation resistance exceeded the 20 MΩ standard, confirming the insulation's integrity. These results suggest that regular maintenance using precise measurement techniques ensures the continued reliability and safety of MV electrical delivery systems. Highlights: Rising Electricity Demand: PT PLN (Persero) faces increasing electricity needs. Advanced Protection Solutions: Innovative equipment addresses conventional limitations. Research Insights: Findings ensure safety and reliability in medium voltage systems. Keywords: Contact Resistance, Insulation Resistance, PMCB, Synchronism Testing
Optimizing Supplier Selection in Indonesia Through Analytical Hierarchy Process (AHP)
Authors: Latif Mochamad Iqbal , Wahyuning Hana Catur 
Published: March 2024

This study introduces a structured multi-criteria decision-making framework using the Analytical Hierarchy Process (AHP), applied to evaluate suppliers based on quality, price, quantity of supply, and plantation area. Effective supplier selection is crucial for maintaining supply chain efficiency. By employing the Expert Choice 11 software, the AHP method quantitatively assessed each criterion, resulting in a definitive ranking of suppliers. The analysis highlighted the paramount importance of quality in supplier selection, assigning it the highest weight (0.565). The outcomes reveal that a meticulous application of AHP significantly enhances decision-making in supplier selection, suggesting its broader applicability in global supply chain management contexts to improve operational efficacy and resilience. Highlights: Structured Evaluation: The AHP method provides a systematic approach to supplier assessment. Emphasis on Quality: Quality is the dominant criterion in supplier selection with the highest weight. Operational Improvement: Implementing AHP enhances supply chain efficiency and decision accuracy. Keywords: Supplier Selection, Analytical Hierarchy Process, Expert Choice
The efficacy of Case-based learning compared with lecture-based learning in medical education: A systematic review and meta-analysis
Authors: Li Guo-Xiang , Lu Bing-rui , Shi Xu-ying , Yin Qing , Huang Shu-Hong , Sun Zhi-Gang 
Published: March 2024

Abstract

Objective:
In recent years, the case analysis method has gradually become more and more popular in the field of medical education. This paper comprehensively evaluates and expounds CBL, and evaluates the role of CBL in clinical medicine.
Method:
A comprehensive literature review was conducted to source relevant studies up to November 2023. The electronic databases interrogated included PubMed, Web of Science and Cochrane Library databases. This systematic search was designed to confirm all randomized controlled trials (RCTs) that juxtaposed the efficacy of Case-Based Learning (CBL) with that of the conventional Lecture-Based Learning (LBL) across various surgical disciplines. The appraisal of methodological soundness adhered strictly to the protocols stipulated in Cochrane Handbook for Systematic Reviews of Interventions, Subsequent meta-analyses were executed utilizing Review Manager 5.4 software, which facilitated an empirical synthesis of the data gleaned from the selected trials.
Result:
A total of 7 RCTs were finally included, with a total sample size of 598 students. The CBL pedagogy significantly increased theoretical knowledge scores (standardized mean difference (SMD) = 1.26, 95%CI: 0.62 to 1.91, p < 0.0001), student satisfaction (risk ratio = 1.25; 95% CI: 0.94 to 1.66; p = 0.13), technology and skills scores (SMD = 0.93, 95% CI: 0.23 to 1.63, p < 0.0001) and overall score (SMD = 1.13, 95% CI: 0.54 to 1.72, p < 0.0001) compared with the LBL teaching model among the dental students. Additionally, a subgroup analysis showed significant differences in the effects of CBL on comprehensive ability scores when comparing theoretical and practical courses.
Conclusions:
Literature was identified by a certain range of reviews to describe their scholarly achievements. The results show that CBL is a positive teaching method in surgical teaching, which can improve clinical ability and student satisfaction. The article provides a framework and suggestions for learning theory for future CBL implementation.
Towards importing renewable hydrogen within planetary boundaries
Authors: Coppitters Diederik , Ghuys Nicolas , Verleysen Kevin , Limpens Gauthier , Jeanmart Hervé , Contino Francesco 
Published: March 2024

Abstract

In pursuit of reducing greenhouse gas emissions, the European Union plans to annually import ten million tonnes of renewable hydrogen. While the economic viability of hydrogen importation is established, environmental assessments are limited to comparisons and lack an evaluation of absolute sustainability. Therefore, we conducted a multi-objective optimization and absolute sustainability assessment with respect to planetary boundaries under current conditions and future scenarios, considering hydrogen, ammonia, and methane as energy carriers. Under current conditions, absolute sustainability is achievable under utilitarian sharing principles, utilizing hydrogen or ammonia as energy carrier, and relying on wind energy and storage at the source location. Looking ahead, cost-effective import pathways, powered by wind and solar energy, can achieve absolute sustainability from 2030 onward, when the world follows an optimistic sustainability pathway with ambitious climate mitigation targets. To attain absolute sustainability in other scenarios, improved practices and new materials in photovoltaic array design should be prioritized.
Analysis and identification of the common genes and molecular pathways of Systemic lupus erythematosus and Rheumatoid arthritis
Authors: Li Siyuan , He Shuyan , Zhang Yan , He Yan , Yi Hongjian , Deng Biao , Huang Yangliang 
Published: March 2024

Abstract

Background
Rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) are diseases that both result from an immune response that does not correctly recognize self-antigens. In fact, the two diseases share a number of clinical manifestations, immunological features, and genetic characterizations. The aim of this study was to identify the common genetic features, immune cell composition, and molecular mechanisms of SLE and RA.
Method
Microarray data for RA and SLE in the Gene Expression Omnibus (GEO)database (http://www.ncbi.nlm.nih.gov/geo) was downloaded. We obtained differentially expressed genes (DEGs) for RA and SLE using ‘limma’ package of R software, and subsequently obtained common DEGs for the intersection of these two diseases. GO and KEGG enrichment analyses of these common DEGs were performed. The Protein-protein interaction (PPI) network was constructed from Search Tool for Retrieval of Interacting Genes (STRING) 11.0 and then hub genes were screened by Cytoscape. After verification datasets verification, we obtained five top significant genetic factors from the hub genes. Then, the immune cell infiltration characteristics analysis of RA and SLE were performed using the CIBERSORT algorithm. In addition, microRNAs (miRNAs) for RA and SLE were acquired from the Human MicroRNA Disease Database (HMDD) and their target genes were to be predicted by miRNA-target interactions database (miRTarbase). The miRNAs–mRNAs network was constructed with intersecting genes and miRNAs. At last, drug candidates for top significant genetic factors were forecasted by the Drug Signature Database (DSigDB).
Results
Using the 'limma' package of R, 232 DEGs for RA, 302 DEGs for SLE, and 52 common DEGs (44 up-regulated and 8 down-regulated) were obtained. Pathway of negative regulation of viral genome replication is most enriched in both RA and SLE. IFI44, IFI44L, IFI6, IFIT3 and PLSCR1 were finally validated as the top significant genetic factors. Dendritic cells activated infiltration was significantly associated with the five top significant genetic factors. The miRNA-mRNA network showed hsa-miR-146a may regulate three top significant genetic factors and play a critical role in RA and SLE.
Conclusions
IFIT3, IFI44, IFI44L, IFI6 and PLSCR1 were identified as relevant genetic markers for the co-occurrence of RA and SLE, which could be considered as promising clues for the treatment of them.
Exciton-Harvesting Enabled Efficient Charged Particle Detection in Zero-Dimensional Halides
Authors: Wu Yuntao , Wang Qian , Wang Chenger , Shi Hongliang , Chen Jie , Beitlerova Alena , Kucerkova Romana , Zhou Zhengyang , Li Yunyun , Nikl Martin , Sun Xilei , Ouyang Xiaoping 
Published: March 2024

Abstract

Materials for radiation detection are critically important and urgently demanded in diverse fields starting from fundamental scientific research to medical diagnostics, homeland security, and environmental monitoring. Low-dimensional halides (LDHs) exhibiting efficient self-trapped exciton (STE) emission with high photoluminescence quantum yield (PLQY) have recently shown a great potential as scintillators. However, an overlooked issue of exciton-exciton interaction in LDHs under ionizing radiation hinders the broadening of its radiation detection applications. Here, we demonstrate an exceptional enhancement of exciton-harvesting efficiency in zero-dimensional (0D) Cs3Cu2I5:Tl halide single crystals by forming strongly localized Tl-bound excitons. Because of the suppression of non-radiative exciton-exciton interaction, an excellent α/β pulse-shape-discrimination (PSD) figure-of-merit (FoM) factor of 2.64, a superior rejection ratio of 10− 9, and a high scintillation yield of 26 000 photons/MeV under 5.49 MeV α-ray are achieved in Cs3Cu2I5:Tl single crystals, outperforming the commercial ZnS:Ag/PVT composites for charged particle detection applications. Furthermore, a radiation detector prototype based on Cs3Cu2I5:Tl single crystals demonstrates the capability of identifying radioactive 220Rn gas for environmental radiation monitoring applications. We believe that exciton-harvesting strategy proposed here can greatly boost the applications of LDHs materials.
Parsing Prokaryotic and Eukaryotic Microbial Genes Simultaneously from Metagenome by a Novel Analysis Workflow
Authors: zhang wei , Han Guomin , Zheng Yanmei , He Xingbing 
Published: March 2024

Abstract

Accurately predicting coding genes from metagenomic samples containing a high proportion of eukaryotic content is a current challenge. Noval reliable methods for the simultaneous prediction of prokaryotic and eukaryotic microbial genes could make contribution to the task. Our group evaluated gene prediction accuracy for various single organisms using MetaGeneMark and MetaEuk pipelines. Based upon the results, an innovative analysis workflow was devised. Our approach involves initially predicting eukaryotic genes using MetaEuk, followed by masking of predicted eukaryotic and partial prokaryotic genes via a Perl program. The subsequent prediction of remaining prokaryotic genes is conducted using MetaGeneMark or metaProdigal. By combining the advantages of both types of software, the new workflow achieved similar quantities and average lengths of eukaryotic genes compared to using MetaEuk alone, while the quantity of predicted prokaryotic genes and viral genes using the new workflow was 14–18% higher compared to using standalone prokaryotic gene prediction software alone. The new workflow effectively enables the rapid and precise retrieval of coding sequences from metagenomes.
A retrospective study of Kinesio Taping in rectus abdominis diastasis treatment and abdominal circumference improvement in postpartum women
Authors: Shi Wei , Niu Xiaoyu , Chen Yueyue , Chen Yu , Huang Xiaoyun , Yu Xiaojuan 
Published: March 2024

Abstract

Background: Rectus abdominis diastasis (RAD)is the key of rehabilitation in postpartum women. This study aimed to evaluate the clinical efficacy of Kinesio Taping (KT) in RAD treatment and abdominal changes.
Methods:Medical records of women with RAD who received KT treatment at the hospital were reviewed. A total of 138 women were included and their demographic characteristics were reviewed, including data before and after RAD treatment, abdominal circumference at the umbilicus and above and below the umbilicus, distance from the xiphoid to the umbilicus, distance from the umbilicus to the pubic symphysis.
Results: The width of RAD decreased from 4.58 ± 1.74 cm to 2.33 ± 0.90 cmafter KT treatment (t = P < 0.001) compared to before treatment. After treatment, the rates of women with normal, mild, moderate, and severe RAD were 28.1%, 44.6%, 26.6% and 0.7%, respectively, which showed statistical significance (P < 0.001). A statistically significant difference was observed in theabdominal circumference reduction at the umbilicus andabove and below umbilicus before and after KT treatment. However, no statistically significant difference was noted in terms of the changes in the distance from the umbilicus to the pubic symphysis. Astatistically significant difference was demonstrated between distance from the umbilicus to the pubicsymphysis and severity between cured and noncured groups.
Conclusions: Preliminary analysis results showed a positive effect of KT treatment in the promotion of RAD recovery and improving abdominal circumference dimension. Furthermore, RAD was positively correlated with a lower abdominal circumference and anterior abdominal injury.
Single-cell RNA sequencing combined with mendelian randomization analysis identifies putatively causal genes associated with Gastric cancer
Authors: Xu Yuan , Jia Li-hua , Yu Wei-ming , Yang Mian 
Published: March 2024

Abstract

To examine the potential causal genes for gastric cancer (GC) susceptibility and effective disease prognosis biomarkers. In this research, public single-cell RNA sequencing (scRNA-seq) data were applied to analyze different cell types and to identify differentially expressed genes (DEGs). The summary data-based Mendelian randomization (SMR) was employed to integrate genome-wide association studies (GWAS) with expression quantitative trait loci (eQTL) to investigate potential genes that causally associated with GC. Besides, a systematic SMR analysis with methylation quantitative trait loci (mQTL) was conducted to reveal the methylation regulatory relationship of GC-related pathogenic genes. In addition, bioinformatic tools including GeneMANIA, gene set enrichment analysis (GSEA), KM-plotter and immune infiltration analysis were used to further explore the biological mechanisms and functions of the candidate genes in GC. Seven cell types and 1707 cell type-specific DEGs were identified by scRNA-seq analysis. Using the SMR and HEIDI test, we screened out 9 genes by integrating GWAS with eQTL analysis from gastric tissue and 26 genes from whole blood. Based on the DEGs identified by scRNA-seq and SMR analysis, 4 positively related genes(HLA-DQB1、PSMB9、RPS18 and TAF1C)were prioritized as candidate GC-causal genes.KM-plotter indicated that aberrant expression of the candidate genes was significantly associated with the prognosis of GC patients. Immune infiltration analysis provides a theoretical basis for these candidate genes to become potential immunotherapeutic targets. These findings may give novel insight into the molecular mechanisms of GC and provide potential biomarkers for therapeutic interventions of GC.
Emulating Brain-like Rapid Learning in Neuromorphic Edge Computing
Authors: Stewart Kenneth , Neumeier Michael , Shrestha Sumit Bam , Orchard Garrick , Neftci Emre 
Published: March 2024

Abstract
Achieving personalized intelligence at the edge with real-time learning capabilities holds enormous promise to enhance our daily experiences and assist in decision-making, planning, and sensing.
Yet, today's technology encounters difficulties with efficient and reliable learning at the edge, due to a lack of personalized data, insufficient hardware capabilities, and the inherent challenges posed by online learning.

Over time and across multiple developmental phases, the brain has evolved to efficiently incorporate new knowledge by gradually building on previous knowledge.
In this work, we emulate this process in digital neuromorphic technology emulating the neural and synaptic processes of the brain by means of two stages of learning.
Initially, a meta-training phase trains the learning hardware's hyperparameters for one-shot learning by deploying a differentiable simulation of local three-factor synaptic plasticity rules implemented in the neuromorphic chip.
This meta-training process refines the synaptic plasticity and related hyperparameters to align with the specific dynamics inherent in the hardware and the given task domain.
During the subsequent deployment stage, these optimized hyperparameters enable fast, data-efficient and accurate learning of new classes.
We demonstrate our approach using event-driven vision sensor data and the Intel Loihi neuromorphic processor with its plasticity dynamics, achieving state-of-the-art accuracy on learning new categories in one-shot in real-time among three distinct task domains.
Our methodology can be deployed with arbitrary plasticity models and can be applied to situations demanding quick learning and adaptation at the edge, such as navigating unfamiliar environments, or learning unexpected categories of data through user engagement.
Nanoliposomal irinotecan with fluorouracil and folinic acid in patients with unresectable or recurrent pancreatic cancer: A multicenter retorospective ovservational study (NAPOLEON-2)
Authors: Kodama Tomoko , Imajima Takashi , Shimokawa Mototsugu , Otsuka Taiga , Kawahira Masahiro , Nakazawa Junichi , Hori Takeshi , Shibuki Taro , Arima Shiho , Ido Akio , Miwa Keisuke , Okabe Yoshinobu , Koga Futa , Ueda Yujiro , Kubotsu Yoshihito , Shimokawa Hozumi , Takeshita Shigeyuki , Nishikawa Kazuo , Komori Azusa , Otsu Satoshi , Hosokawa Ayumu , Sakai Tatsunori , Sakai Kenji , Oda Hisanobu , Kawahira Machiko , Arita Shuji , Honda Takuya , Taguchi Hiroki , Tsuneyoshi Kengo , Kawaguchi Yasunori , Fujita Toshihiro , Sakae Takahiro , Shirakawa Tsuyoshi , Mizuta Toshihiko , Mitsugi Kenji 
Published: March 2024

Abstract

Nanoliposomal irinotecan with fluorouracil and folinic acid (NFF) is a standard regimen after gemcitabine-based therapy for patients with unresectable or recurrent pancreatic cancer. However, there are limited clinical data on its efficacy and safety in the real-world. We therefore initiated a retrospective and prospective observational study (NAPOLEON-2). The results of the retrospective part were reported herein. In this retrospective study, we evaluated 161 consecutive patients who received NFF as second-or-later-line regimen. The main endpoint was overall survival (OS), and the other endpoints were response rate, disease control rate, progression-free survival (PFS), dose intensity, and adverse events (AEs). The median age was 67 years (range, 38–85 years). The median OS and PFS were 8.1 and 3.4 months, respectively. The objective response and disease control rates were 5% and 52%, respectively. The median relative dose intensity was 81.6% for nanoliposomal irinotecan and 82.9% for fluorouracil. Grade 3 or 4 hematological and nonhematological AEs occurred in 47 and 42 patients, respectively. Common grade 3 or 4 AEs included neutropenia (24%), anorexia (12%), and leukocytopenia (12%). Subanalysis of patients treated with second-line and third-or-later-line demonstrated no statistical significant difference in OS (7.6 months vs. 9.1 months, respectively; hazard ratio, 0.92; 95% confidence interval, 0.64–1.35;p= 0.68). In conclusion,NFF has acceptable efficacy and safety profile even in real-world clinical settings. The prospective study is in progress to validate these findings.
The effects of AgNO3 combined with temperature stress on the transcriptome of Gentiana rigescens and the accumulation of gentiopicroside
Authors: Zhang Ting , Li Chunyu , Wang Mengqi , Gu Yunxia , Zhou Xuhong , Liu Xiaoli 
Published: March 2024

Abstract
The root and rhizome of Gentiana rigescens are used as important traditional Chinese medicine and ethno medicine, with gentiopicroside is the major bioactive compounds. In order to explore the effects of temperature and heavy metals stress on the gentiopicroside, we investigated the accumulation of gentiopicroside and the transcriptional response of G. rigescens when exposed to a combination of AgNO3 and temperature stress. AgNO3 (100 µmol/L) was sprayed onto sterile Gentiana rigescens seedlings and cultured at three temperatures (22°C, 10°C and 34°C); control plants were sprayed with sterile water and cultured at 22°C. Gentiopicroside levels were determined by high-performance liquid chromatography (HPLC), and the differential expression of genes in the gentiopicroside biosynthesis pathway in response to different treatments was analyzed by an IIIumina Hiseq 6000 system. Analysis showed that the levels of gentiopicroside in response to a combination of AgNO3 and temperature treatment were significantly higher than that of those in the control; the 100µmol/L AgNO3 and 10°C treatment group had the highest levels of gentiopicroside. A total of 135 197 unigenes were identified by transcriptome sequencing, with an average length of 1351 base pairs (bp). A total of 238 unigenes, encoding 19 key enzymes, were identified in the gentiopicroside biosynthesis pathway. The combination of 100µmol/L AgNO3 and 10°C treatment led to the largest number of differentially expressed transcription factors when compared with the control. Our research provides key biological information for elucidating the molecular mechanisms underlying the biosynthesis of gentiopicroside in response to the combination of AgNO3 and temperature stress.