bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synbiotic potential of carrot juice supplemented with Lactobacillus spp. and inulin or fructooligosaccharides
Authors: Nazzaro Filomena , Fratianni Florinda , Sada Alfonso , Orlando Pierangelo 
Published: August 2008

AbstractBACKGROUND: The influence of the addition of two probiotic strains, Lactobacillus rhamnosus and Lactobacillus bulgaricus, and the prebiotic components inulin and fructooligosaccharides on carrot juice was investigated in order to evaluate the possibility of producing a functional vegetal beverage.RESULTS: Both bacterial strains were capable of growing in carrot juice, reaching nearly 5 × 109 colony‐forming units after a 48 h fermentation, and the pH was reduced to 3.5–3.7 or below. The viable cell counts of the two lactobacilli in the fermented juice after 4 weeks of storage at 4 °C, demonstrated good survival of the two strains at low pH. Some biochemical characteristics of the fermented juice, such as β‐carotene content and antioxidant activity, were also preserved, indicating that the metabolism of the Lactobacillus spp. did not degrade these nutritional components after 4 weeks of storage at 4 °C. The positive effect was more evident when the juice was inoculated with Lactobacillus rhamnosus. The presence of inulin and fructooligosaccharides did not alter the cell counts or the biochemical characteristics of the fermented juice.CONCLUSION: We propose this as a health juice and functional beverage for vegetarians or consumers who are allergic to dairy products. Copyright © 2008 Society of Chemical Industry
Consensus statement on the loco regional treatment of colorectal cancer with peritoneal dissemination
Authors: Esquivel Jesus , Elias Dominique , Baratti Dario , Kusamura Shigeki , Deraco Marcello 
Published: August 2008

AbstractMedical management with combinations of cytotoxic chemotherapy, and/or biological agents, has resulted in an unprecedented median survival >20 months in patients with Stage IV colorectal cancer. The management of disease limited to the peritoneal cavity has been controversial and at the present time, there is no published data that outlines the impact of these new therapeutic regimens when given to patients with colorectal cancer with metastatic disease confined to the peritoneum. Over the last 5 years, an increasing number of international treatment centers have published their prospective results using cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) in the management of peritoneal surface malignancies of colorectal origin and have shown that good long‐term results can be achieved with a complete cytoreduction and HIPEC. However, most of the surgical data comes from Phase II studies from single institutions and there is a wide range on inclusion/exclusion criteria, drugs, temperatures and methods of delivering the heated chemotherapy. This manuscript will analyze and discuss the results of a group of health care providers trying to achieve a consensus statement in the management of this group of patients. J. Surg. Oncol. 2008;98:263–267. © 2008 Wiley‐Liss, Inc.
Consensus statement on the loco‐regional treatment of appendiceal mucinous neoplasms with peritoneal dissemination (pseudomyxoma peritonei)
Authors: Moran Brendan , Baratti Dario , Yan Tristan D. , Kusamura Shigeki , Deraco Marcello 
Published: August 2008

AbstractPseudomyxoma peritonei (PMP) is a rare condition mostly originating from low malignant potential mucinous tumours of the appendix. Although this disease process is minimally invasive and rarely causes haematogenous or lymphatic metastases, expectation of long‐term survival are limited with no prospect of cure. Recently, the combined approach of cytoreductive surgery (CRS) and perioperative loco‐regional chemotherapy (PLC) has been proposed as the standard of treatment for the disease. The present paper summarizes the available literature data and the main features of the comprehensive loco‐regional treatment of PMP. The controversial issues concerning the indications and technical methodology in PMP management were discussed through a web‐based voting system by internationally known experts. Results were presented for further evaluation during a dedicated session of “The Fifth International Workshop on Peritoneal Surface Malignancy (Milan, Italy, December 4–6, 2006)”. The experts agreed that multiple prospective trials support a benefit of the procedure in terms of improved survival, as compared with historical controls. Concerning the main controversial methodological questions, there was an high grade of consistency among the experts and agreement with the findings of the literature. J. Surg. Oncol. 2008;98:277–282. © 2008 Wiley‐Liss, Inc.
Morbidity, toxicity, and mortality classification systems in the local regional treatment of peritoneal surface malignancy
Authors: Younan Rami , Kusamura Shigeki , Baratti Dario , Cloutier Alexis‐Simon , Deraco Marcello 
Published: August 2008

AbstractTo reach a consensus for reporting complications related to cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). Reporting the adverse events related to CRS + HIPEC is not standardized yet. Post‐operative complications can be divided in two categories: the effects of surgical manipulation per se and the toxic effects of the heated intraoperative chemotherapy. Additive and/or synergistic effects also exist. Different centers have published their experience with regard to the complications associated with the procedure. Various classification systems have been used which makes a temptative comparison of the different techniques and results almost impossible. An effort was made here to review the existing major classification systems: The Bozzetti classification, the Clavien classification (and two proposed modifications from Feldman et al. and Elias et al.) and the Common terminology criteria for adverse events (CTCAE) version 3.0 of the National Institute of Health (NIH) criteria. A related document was sent to an international panel of experts. The CTCAE was adopted by the panel of experts as the unique classification system to be used for reporting complications related to CRS + HIPEC. J. Surg. Oncol. 2008;98:253–257. © 2008 Wiley‐Liss, Inc.
The Delphi approach to Attain consensus in methodology of local regional therapy for peritoneal surface malignancy
Authors: Kusamura Shigeki , Baratti Dario , Younan Rami , Deraco Marcello 
Published: August 2008

AbstractAt the Fifth International Workshop on Peritoneal Surface Malignancy (PSM), held in Milan, December 2006, the consensus on technical aspects of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) was obtained through the Delphi process. The following topics were discussed: pre‐operative workup; eligibility to CRS + HIPEC; intra‐operative staging system; technical aspects of surgery; residual disease classification systems; HIPEC: nomenclature and modalities; drugs, carrier solution and optimal temperature; morbidity grading systems. Conflicting points regarding above‐mentioned topics were elaborated and voted in two rounds by a panel of international experts in local‐regional therapy. The purpose of this manuscript is to describe the organization and the methodology of the consensus statements and to interpret and discuss the implications of the most striking results. J. Surg. Oncol. 2008;98:217–219. © 2008 Wiley‐Liss, Inc.
The eligibility for local‐regional treatment of peritoneal surface malignancy
Authors: Verwaal Vic J. , Kusamura Shigeki , Baratti Dario , Deraco Marcello 
Published: August 2008

AbstractAt the Fifth International Workshop on Peritoneal Surface Malignancy, held in Milan, the consensus on technical aspects of cytoreductive surgery (CRS) for peritoneal surface malignancy was obtained through the Delphi process. General conflicting points concerning the eligibility to the local‐regional therapy were discussed and voted. J. Surg. Oncol. 2008;98:220–223. © 2008 Wiley‐Liss, Inc.
The consensus statement on the locoregional treatment of abdominal sarcomatosis
Authors: Rossi Carlo Riccardo , Casali Paolo , Kusamura Shigeki , Baratti Dario , Deraco Marcello 
Published: August 2008

AbstractAbdominal sarcomatosis (AS) is a rare condition characterized by soft tissue sarcoma spreading throughout the abdomen, in the absence of extra‐abdominal dissemination. Retroperitoneal sarcomas, pelvic sarcomas, particularly uterine leiomyosarcoma, and gastrointestinal stromal tumors (GISTs) most frequently give rise to AS. Systemic chemotherapy is the standard of care for AS from non‐GIST sarcomas, but with an essentially palliative aim and major limitations. Innovative targeted therapies has deeply affected the natural history of GIST, at least in prolonging significantly survival in responsive patients. In this context, the notion that abdominal spread in the lack of extra‐peritoneal lesions may typically occur in a number of patients, along with the dismal prognosis generally carried by AS, has prompted a few centers to perform cytoreductive surgery and perioperative intraperitoneal chemotherapy. To date, the rarity of these presentations makes it difficult to evaluate the clinical results and the role of combined local‐regional treatment is still a matter of debate. This article presents the results of a group of experts from around the World trying to achieve a consensus statement in AS comprehensive management. A questionnaire was placed on the website of the 5th International Workshop on Peritoneal Surface Malignancy and the experts voted via internet. J. Surg. Oncol. 2008;98:291–294. © 2008 Wiley‐Liss, Inc.
The intraoperative staging systems in the management of peritoneal surface malignancy
Authors: Portilla A. Gomez , Shigeki Kusamura , Dario Baratti , Marcello Deraco 
Published: August 2008

AbstractThe establishment of a rationale guideline for intraoperative staging system the extent of carcinomatosis is warranted. The quantitation of tumor found at the time of surgical exploration of the abdomen has proven to be of value in assessment of prognosis and treatment planning in patients with peritoneal carcinomatosis. Four different assessments systems have been employed more frequently, thus far. The advantages and disadvantages of each classification systems are described and discussed. The results of the Consensus of the last 5th International Workshop on Peritoneal Surface malignancy of Milan, December 2006 are presented. J. Surg. Oncol. 2008;98:228–231. © 2008 Wiley‐Liss, Inc.
Preoperative investigations in the management of peritoneal surface malignancy with cytoreductive surgery and perioperative intraperitoneal chemotherapy: Expert consensus statement
Authors: Yan Tristan D. , Morris David L. , Shigeki Kusamura , Dario Baratti , Marcello Deraco 
Published: August 2008

AbstractAt the Fifth International Workshop on Peritoneal Surface Malignancy, in Milan, the consensus on preoperative investigations for peritoneal surface malignancy was obtained through the Delphi process. The results showed that 100% of the voters considered that contrast‐enhanced multi‐sliced CT was the fundamental imaging modality, whereas MRI, PET, laparoscopy and serum tumor markers were regarded as useful, but not fundamental investigational modalities. J. Surg. Oncol. 2008;98:224–227. © 2008 Wiley‐Liss, Inc.
Treatment failure following complete cytoreductive surgery and perioperative intraperitoneal chemotherapy for peritoneal dissemination from colorectal or appendiceal mucinous neoplasms
Authors: Bijelic Lana , Yan Tristan D. , Sugarbaker Paul H. 
Published: August 2008

AbstractBackgroundPeritonectomy combined with perioperative intraperitoneal chemotherapy is a successful treatment option for patients with peritoneal dissemination of appendiceal and colorectal malignancy. Despite its efficacy, recurrences remain a common problem.MethodsPatients with peritoneal dissemination from appendiceal or colorectal malignancy who underwent complete cytoreduction and perioperative intraperitoneal chemotherapy were included in this study. Data regarding recurrent disease found on abdominal exploration and/or diagnostic studies was extracted from a prospective database and analyzed.ResultsSeventy patients with colorectal cancer carcinomatosis and 402 with appendiceal neoplasm were analyzed. Forty‐nine of 70 and 111 of 402 patients developed documented recurrences. The median survival of 49 patients with colorectal cancer was 33 months while the median survival for patients with appendiceal neoplasms was not reached. The most common type of recurrent disease was a localized intra‐abdominal recurrence for both appendiceal and colon cancer patients. Patients who underwent second surgery for recurrent disease had an improved survival.ConclusionAdditional treatments should be strongly considered in patients who fail an initial cytoreduction combined with perioperative intraperitoneal chemotherapy. This resulted in 5‐year survival in 17% of colorectal patients and 70% of the appendiceal mucinous neoplasm patients. J. Surg. Oncol. 2008;98:295–299. © 2008 Wiley‐Liss, Inc.
Trauma history characteristics and subsequent PTSD symptoms in motor vehicle accident victims
Authors: Irish Leah , Ostrowski Sarah A. , Fallon William , Spoonster Eileen , Dulmen Manfred van , Sledjeski Eve M. , Delahanty Douglas L. 
Published: August 2008

AbstractThe present study examined the relationship between trauma history characteristics (number and type of traumas, age at first trauma, and subjective responses to prior traumas) and the development of posttraumatic stress disorder (PTSD) symptoms following a motor vehicle accident (MVA). One hundred eighty‐eight adult MVA victims provided information about prior traumatization and were evaluated for PTSD symptoms 6 weeks and one year following the MVA. Results indicated that after controlling for demographics and depression, prior trauma history characteristics accounted for a small, but significant amount of the variance in PTSD symptoms. Distress from prior trauma and number of types of prior traumas were the most meaningful trauma history predictors. Results encourage further evaluation of trauma history as a multifaceted construct.
Relationships among PTSD symptoms, social support, and support source in veterans with chronic PTSD
Authors: Laffaye Charlene , Cavella Steven , Drescher Kent , Rosen Craig 
Published: August 2008

AbstractThe present study examined the temporal relationship between posttraumatic stress disorder (PTSD) and social support among 128 male veterans treated for chronic PTSD. Level of perceived interpersonal support and stressors were assessed at two time points (6 months apart) for four different potential sources of support: spouse, relatives, nonveteran friends, and veteran peers. Veteran peers provided relatively high perceived support and little interpersonal stress. Spouses were seen as both interpersonal resources and sources of interpersonal stress. More severe PTSD symptoms at Time 1 predicted greater erosion in perceived support from nonveteran friends, but not from relatives. Contrary to expectations, initial levels of perceived support and stressors did not predict the course of chronic PTSD symptoms.
Nonnightmare distressed awakenings in veterans with posttraumatic stress disorder: Response to prazosin
Authors: Thompson Charles E. , Taylor Fletcher B. , McFall Miles E. , Barnes Robert F. , Raskind Murray A. 
Published: August 2008

AbstractTwenty‐two veterans with posttraumatic stress disorder (PTSD) were assessed for trauma‐related nightmares and nonnightmare distressed awakenings (NNDA) before and after treatment with the alpha‐1 adrenoreceptor antagonist prazosin at an average bedtime dose of 9.6 mg/day. Ratings combining frequency and intensity dimensions of trauma‐related nightmares decreased from 3.6 to 2.2, NNDA from 5.2 to 2.1, and sleep difficulty from 7.2 to 4.1 per week. These results suggest that increased brain adrenergic activity may contribute to the pathophysiology of both trauma‐related nightmares and NNDA in PTSD.
Tonic immobility mediates the influence of peritraumatic fear and perceived inescapability on posttraumatic stress symptom severity among sexual assault survivors
Authors: Bovin Michelle J. , Jager‐Hyman Shari , Gold Sari D. , Marx Brian P. , Sloan Denise M. 
Published: August 2008

AbstractThis study evaluated whether tonic immobility mediates the relations between perceived inescapability, peritraumatic fear, and posttraumatic stress disorder (PTSD) symptom severity among sexual assault survivors. Female undergraduates (N = 176) completed questionnaires assessing assault history, perceived inescapability, peritraumatic fear, tonic immobility, and PTSD symptoms. Results indicated that tonic immobility fully mediated relations between perceived inescapability and overall PTSD symptom severity, as well as reexperiencing and avoidance/numbing symptom clusters. Tonic immobility also fully mediated the relation between fear and reexperiencing symptoms, and partially mediated relations between fear and overall PTSD symptom severity, and avoidance/numbing symptoms. Results suggest that tonic immobility could be one path through which trauma survivors develop PTSD symptoms. Further study of tonic immobility may inform our ability to treat trauma victims.
Financial and social circumstances and the incidence and course of PTSD in Mississippi during the first two years after Hurricane Katrina
Authors: Galea Sandro , Tracy Melissa , Norris Fran , Coffey Scott F. 
Published: August 2008

AbstractHurricane Katrina was the most devastating natural disaster to hit the United States in the past 75 years. The authors conducted interviews of 810 persons who were representative of adult residents living in the 23 southernmost counties of Mississippi before Hurricane Katrina. The prevalence of posttraumatic stress disorder (PTSD) since Hurricane Katrina was 22.5%. The determinants of PTSD were female gender, experience of hurricane‐related financial loss, postdisaster stressors, low social support, and postdisaster traumatic events. Kaplan‐Meier survival curves suggest that exposure to both hurricane‐related traumatic events and to financial and social stressors influenced the duration of PTSD symptoms. Postdisaster interventions that aim to improve manipulable stressors after these events may influence the onset and course of PTSD.
Alternariol acts as a topoisomerase poison, preferentially affecting the IIα isoform
Authors: Fehr Markus , Pahlke Gudrun , Fritz Jessica , Christensen Morten O. , Boege Fritz , Altemöller Martina , Podlech Joachim , Marko Doris 
Published: August 2008

AbstractAlternariol (AOH), a mycotoxin formed by Alternaria alternata, has been reported to possess genotoxic properties. However, the underlying mechanism of action is unclear. Here, we tested the hypothesis that interactions with DNA–topoisomerases play a role in the DNA‐damaging properties of AOH. First we compared DNA‐damaging properties of AOH with other Alternaria mycotoxins such as AOH monomethyl ether (AME), altenuene and isoaltenuene. AOH and AME significantly increased the rate of DNA strand breaks in human carcinoma cells (HT29, A431) at micromolar concentrations, whereas altenuene and isoaltenuene did not affect DNA integrity up to 100 μM. Next, we selected AOH as the most DNA‐damaging Alternaria metabolite for further studies of interactions with DNA topoisomerases. In cell‐free assays, AOH potently inhibited DNA relaxation and stimulated DNA cleavage activities of topoisomerase I, IIα and IIβ. Stabilisation of covalent topoisomerase II–DNA intermediates by AOH was also detectable in cell culture, and here, the IIα isoform was preferentially targeted. AOH is thus characterised as a poison of topoisomerase I and II with a certain selectivity for the IIα isoform. Since topoisomerase poisoning and DNA strand breakage occurred within the same concentration range, poisoning of topoisomerase I and II might at least contribute to the genotoxic properties of AOH.
Does the lipid membrane composition of arsonoliposomes affect their anticancer activity? A cell culture study
Authors: Zagana Paraskevi , Haikou Maria , Giannopoulou Eleftheria , Ioannou Panayiotis V. , Antimisiaris Sophia G. 
Published: August 2008

AbstractSonicated arsonoliposomes were prepared using arsonolipid with palmitic acid acyl chain (C16), mixed with phosphatidylcholine (PC)‐based or 1,2‐distearoyl‐sn‐glycero‐3‐phosphocholine (DSPC)‐based, and cholesterol (Chol) with C16/DSPC/Chol 8:12:10 molar ratio. PEG‐lipid (1,2‐distearoyl‐sn‐glycero‐3‐phosphoethanolamine conjugated to polyethylenoglycol 2000) containing vesicles (PEGylated‐arsonoliposomes; PC‐based and DSPC‐based) were also prepared. The cytotoxicity of these arsonoliposomes towards different cancer cells (human promyelocytic leukaemia NB4, Prostatic cancer PC3, human breast adenocarcinoma MDA‐MB‐468, human T‐lymphocyte (MT‐4) and also towards human umbilical vein endothelial cells (HUVECs) was evaluated by calculating the arsonoliposome‐induced growth inhibition of the cells by the MTT assay. IC‐50 values were interpolated from cell number/arsonoliposome concentration curves. The results reveal that all types of arsonoliposomes evaluated significantly inhibit the growth of most of the cancer cells studied (PC3, NB4, MT4) with the exception of the MDA‐MB‐468 breast cancer cells which were minimally affected by arsonoliposomes; in some cases even less than HUVEC. Nevertheless, for the same cell type the differences between the different types of arsonoliposomes were significant but not proportional to their stability, indicating that the formation of arsonoliposomes with very stable membranes is not a problem for their anticancer activity. Thereby it is concluded that arsonoliposome composition should be adjusted in accordance to their in vivo kinetics and the desired, for each specific application, biodistribution of As and/or encapsulated drug.
Transepithelial transport across Caco‐2 cell monolayers of antihypertensive egg‐derived peptides. PepT1‐mediated flux of Tyr‐Pro‐Ile
Authors: Miguel Marta , Dávalos Alberto , Manso María A. , de la Peña Gema , Lasunción Miguel A. , López‐Fandiño Rosina 
Published: August 2008

AbstractThis paper examines the in vitro transepithelial transport of antihypertensive peptides derived from egg proteins using Caco‐2 cell monolayers. Ovokinin (FRADHPFL) was absorbed intact through the Caco‐2 cell epithelium, although it was also susceptible to the action of brush‐border aminopeptidases that yielded shorter fragments prior to their transport. The tripeptide YPI was resistant to cellular peptidases and transported through the monolayer, what suggests that the reduction in systemic blood pressure caused by this peptide may be mediated by effects at tissue level. Its pathway for transepithelial absorption was examined using inhibitors of the different mechanisms for oligopeptide transport in the intestinal tract. The main route involved in the transepithelial flux of YPI is probably the peptide H+‐coupled transporter PepT1. These results highlight the potential of antihypertensive peptides to be used in the formulation of functional foods.