bluuebunny/crossref_metadata_2025_split huggingface dataset:
Monitoring Changes in the Jakarta Flood Disaster with Using Sentinel 2A Imagery
Authors: Sulandari Uci , Mumpuni Ngesti Sri , Hendrawati Lulus Suci , Cahyana Destika 
Published: March 2024

DKI Jakarta Province is one of the provinces in Indonesia with a relatively high incidence of flooding since its establishment in the Dutch East Indies era because geomorphologically Jakarta is a floodplain area. On the other hand, land pressure by increasing urbanization in the city of Jakarta results in the increasingly limited availability of decent housing land for the community so that lands that should be water catchment areas and riverbanks are transformed into densely populated flying areas which ultimately reduces water absorption capacity in the Jakarta area. To obtain fast data in identifying flood-affected areas, the technique of identifying the potential extent and distribution of flooding by utilizing the remote sensing NDWI (Normalized Difference Water Index) method and/or using the Modified Normalized Difference Water Index (MNDWI) method from the free data Sentinel 2A satellite can be useful to provide data input to relevant parties in DKI Jakarta Province. Opportunities and constraints The application of NDWI and/or MNDWI techniques will greatly assist mapping activities and identification of the distribution of flood areas as an alternative input to policymakers for action and anticipation of areas with high flood potential. This research is one of the first steps and input to the DKI Jakarta Government in making strategies and roadmaps for flood mitigation in DKI Jakarta.
Multisensory Processing in Music
Authors: Russo Frank 
Published: March 2024

<p> </p>
<p>This chapter provides an overview of multisensory processing in music by individuals with normal hearing, hearing loss, and deafness. The first section provides an account of theory and evidence regarding the neural mechanisms underpinning multisensory processing. The second section considers auditory-only processing of music with a focus on lateralization, basic modularity, and pathways. The final section considers non-auditory and multisensory processing of pitch, timbre, and rhythm. For each dimension, psychophysical evidence is presented before reviewing the extant neuroscientific evidence. Where no neuroscientific evidence exists, proposals have been made about the types of neural mechanisms that may be involved. Neuroplastic changes following deafness are also considered. The chapter ultimately argues that although most individuals will justifiably focus on sound as the core of music processing, a more inclusive and nuanced consideration of music takes a multisensory perspective, involving the integration of inputs from auditory, visual, somatosensory, vestibular, and motor areas.</p>
Age-Related Difference in Melodic Pitch Perception Is Probably Mediated by Temporal Processing: Empirical and Computational Evidence
Authors: Russo Frank , Ives D Timothy , Goy Huiwen , Pichora-Fuller M. Kathleen , D. Patterson Roy 
Published: March 2024

<div><strong>Objective: </strong>This study was designed to examine whether age-related differences in melodic pitch perception may be mediated by temporal processing. Temporal models of pitch suggest that performance will decline as the lowest component of a complex tone increases in frequency, regardless of age. In addition, if there are age-related deficits in temporal processing in older adults, this group may have reduced performance relative to younger adults even in the most favorable conditions.</div>
<div><strong>Design: </strong>Six younger adults and 10 older adults with clinically normal audiograms up to 8 kHz were tested in a melodic pitch perception task. In each trial, two consecutive four-note melodies were presented to the listener. Melodies were identical with the exception of one note in the second melody that was shifted in pitch. The listener was required to identify which note was shifted. All notes consisted of eight successive harmonic components, with the average lowest component manipulated to be the 4th, 8th, or 12th component of the harmonic series, with lower components being absent.</div>
<div><strong>Results: </strong>Age-related differences in melodic pitch perception were only apparent when stimulus parameters favored temporal processing of pitch. Furthermore, modeling a loss of periodicity coding yielded an outcome consistent with the observed behavioral results. Although younger adults generally outperformed older adults, about one-quarter of the older adults performed at levels that were equivalent to those of younger adults. The only follow-up tests that were able to differentiate these exceptional older adults were tests that would be sensitive to temporal processing: Fundamental frequency difference limens and 500 Hz pure-tone difference limens. In contrast, otoacoustic emissions and high-frequency pure-tone thresholds, which are more commonly associated with spectral processing deficits, were not able to differentiate older exceptional adults from older typical adults.</div>
<div><strong>Conclusion: </strong>Age-related declines in temporal processing contribute to deficits in melodic pitch perception. However, some exceptional older adults with normal audiograms preserve excellent temporal processing and continue to perform at levels that are typical of younger adults.</div>
Literature Review: Pengaruh Asupan Karbohidrat, Protein dan Lemak terhadap Resiko Stunting Anak Usia 2-5 Tahun
Authors: Abdullah Rezky Putri Indarwati 
Published: March 2024

Stunting mengacu pada gangguan pertumbuhan dan perkembangan pada anak-anak di bawah usia lima tahun. Anak-anak yang panjang / tinggi badannya terhadap nilai Z-score lebih dari dua standar deviasi di bawah median standar pertumbuhan anak. Untuk mengetahui pengaruh asupan karbohidrat, protein dan lemak terhadap resiko stunting anak usia 2-5 tahun. Penelitian ini menggunakan desain non-eksperimental dengan metode Narrative Review. Penelusuran pustaka dilakukan melalui jurnal nasional, jurnal internasional, dan proceeding book. Berdasarkan literatur nasional dan internasional terdapat 22 jurnal hubungan asupan makronutrien terhadap anak stunting 2-5 tahun. Kesimpulan Ada pengaruh asupan karbohidrat dapat menyebabkan stunting pada anak usia 2-5 tahun karena karbohidrat memiliki fungsi menyuplai energi untuk tubuh supaya dapat melakukan aktivitasnya. Adanya pengaruh asupan protein dapat menyebabkan stunting pada anak usia 2-5 tahun karena protein dapat meningkatkan kadar Insulin Growth Factor 1 (IGF-1) yang merupakan mediator dari hormon pertumbuhan dan pembentukan matriks tulang, Adanya pengaruh asupan lemak dapat menyebabkan stunting pada anak usia 2-5 tahun karena lemak mengandung asam lemak esensial yang memiliki peran dalam mengatur kesehatan dan terdapat hubungan asupan karbohidrat, protein dan lemak dengan kejadian anak stunting 2-5 tahun
Karakteristik Pasien Otitis Media Supuratif Kronik di Rumah Sakit Ibnu Sina Makassar Periode Juni 2018 – Desember 2021
Authors: Syopyanah Sri Puspa  , Nasaruddin Hermiaty , Arifuddin Andi Tenri Sanna , Pratama Ahmad Ardhani , Syamsu Rijal  
Published: March 2024

Kasus otitis media supuratif kronik yang sejak dahulu diketahui merupakan penyakit dengan prevalensi yang tinggi bahkan jika tidak ditangani dengan baik dapat mengarah keberbagai komplikasi yang mengakibatkan penurunan kualitas hidup hingga kematian. Jumlah penderita kecil kemungkinan untuk berkurang bahkan mungkin akan bertambah setiap tahunnya mengingat kondisi ekonomi yang masih rendah, kesadaran masyarakat akan kesehatan yang masih rendah, dan sering tidak tuntasnya pengobatan yang dilakukan oleh pasien. Penelitian observasional dengan pendekatan deskriptif, desain penelitian yang digunakan adalah Cross Sectional Study. Jumlah total penderita OMSK di Rumah Sakit Ibnu Sina Makassar periode Juni 2018 – Desember 2021 adalah sebanyak 50 pasien. Didapatkan hasil bahwa distribusi proporsi tertinggi pasien OMSK berdasarkan usia ada pada kelompok usia 20 – 60 tahun sebanyak 70% dibandingkan dengan kelompok usia lainnya, berdasarkan jenis kelamin proporsi tertinggi adalah perempuan sebanyak 62% dibandingkan laki-laki sebanyak 38%, berdasarkan keluhan utama proporsi tertinggi adalah otorrhea sebanyak 44% dibandingkan dengan keluhan utama lainnya, berdasarkan lokasi perforasi yang terbanyak adalah pasien dengan perforasi sentral sebanyak 96% dibandingkan marginal dan atik sebanyak 2%, berdasarkan tipe OMSK yang terbanyak adalah pasien dengan OMSK tipe benigna sebanyak 96% dibandingkan maligna sebanyak 4%. Pasien OMSK berdasarkan usia penderita terbanyak adalah umur 20-60 tahun (dewasa), jenis kelamin terbanyak yaitu perempuan, keluhan utama terbanyak yaitu otorrhea, lokasi perforasi terbanyak yaitu perforasi sentral, tipe OMSK terbanyak yaitu tipe benigna
Restoring degraded landscapes and sustaining livelihoods: sustainability assessment (cum-review) of integrated landscape management in sub-Saharan Africa
Authors: Birhanu Birhanu Zemadim , Desta Gizaw , Cofie Olufunke , Tilahun Seifu Admassu , Mabhaudhi Tafadzwanashe 
Published: March 2024

IntroductionLand degradation is a significant environmental challenge across sub-Saharan Africa. In recent decades, efforts have been undertaken, with varying successes, to rehabilitate degraded rural landscapes. However, there needs to be more evidence on the outcomes regarding enhanced productivity, environmental management, and socio-economic benefits.MethodsThis study uses a case study approach, using contrasting sites from Ethiopia and Mali to appraise restoration innovations implemented through various programs. Two distinct sites were chosen from each of the study cases, and an extensive literature search was conducted to document the evidence, focusing on the sustainability gains derived from integrated landscape management (ILM). For this, the sustainable intensification assessment framework (SIAF) was used, encompassing five domains, namely productivity, economic, environmental, social, and human condition, and featuring scales from plot to landscape, all facilitated by simplified yet robust indicators such as yield, soil loss, net income, land access, and food availability.ResultsResults highlighted a higher productivity gain (35% to 55%) and an improved socio-economic benefit (&gt;20%). The ILM in the Ethiopian highlands enabled a significant improvement in wheat and barley yield (p &lt; 0.01). Introducing new crop varieties integrated with the in-situ and ex-situ practices enabled diversifying crops across the landscape and significantly reduced runoff and soil loss (p &lt; 0.05). By increasing the cultivable land by 44%, household income was increased by selling potatoes and agroforestry products. In Mali, ILM practices reduced soil loss to 4.97t/ha from 12.1t/ha. In addition to the improvements in the yield of sorghum and maize (33% and 63%, respectively), rehabilitating the once marginal and abandoned landscape in Mali enabled landless and female-headed households to work together, improving the social cohesion among the groups. The introduction of irrigation facilities enabled widowed women to increase household vegetable consumption by 55% and increase their income by 24%.DiscussionThe study showed positive evidence from ILM practices in the two contrasting landscapes. However, there is a need to address challenges related to the absence of timely data monitoring and documentation of successful practices. For this, the generation of evidence-based data and the use of advanced geo-spatial tools such as Remote Sensing and GPS-installed drones are recommended.
How does the landscape uniformity in different forest landscapes affect the visual behavior and preference evaluation intention of participants—a case study of forest landscape in northern China (Liaoning)
Authors: Gao Yu , Sun Xiaomei , Zhang Zhi , Zhang Weikang , Meng Huan , Zhang Tong 
Published: March 2024

BackgroundHigh-quality in-forest landscapes are very important when landscape designers and foresters are planning and managing forest landscape resources. Understanding people’s visual behavior toward in-forest landscapes plays an important role in creating high-quality in-forest landscapes.MethodsPeople’s visual information about in-forest landscapes with different landscape uniformity (IFLDLU) was visualized and digitized by eye-tracking technology and virtual reality method of picture, and the data were statistically analyzed by MANOVA, one-way ANOVA, Spearman’s rho correlation analysis, and linear regression in SPSS.PurposeThis study aimed to discuss the influence of landscape uniformity on people’s visual behavior, satisfaction preference, and re-viewing intention, and to reveal the main reasons for the spatial cognitive characteristics of in-forest scenes that arouse their visual attention and re-viewing intention.Main results(1) The landscape uniformity of the in-forest landscape (IFL) affects people’s observation mode; (2) People’s visual attention differs across in-forest landscape uniformity, as mainly reflected in visual span and pupil diameter; (3) Overall, people prefer a cluster distribution of in-forest landscapes, for which they have higher re-viewing intentions; (4) Spatial cognitive characteristics that arouse participants’ visual behavior, satisfaction preference, and re-viewing intention vary with the landscape uniformity of in-forest landscapes. Among them, many spatial cognitive characteristics should be optimized in random distribution for IFL, arousing higher satisfaction preference and re-viewing intention. Therefore, when planning, designing, and managing in-forest landscapes, we suggest that spatial cognitive characteristics should be improved and optimized based on the landscape uniformity of the IFL to arouse participants’ positive visual attention, enhance their place identity, make them “reluctant to bid farewell,” and further arouse their place attachment.
Genetic correlation between circulating metabolites and chalazion: a two-sample Mendelian randomization study
Authors: Zhang Xin , Cai Yuying , Jiang Yaping , Du Wei , An Weishu , Fu Qiangqiang , Chen Yihui 
Published: March 2024

Background: Lipid metabolism disorders were observationally associated with chalazion, but the causality of the related circulating metabolites on chalazion remained unknown. Here, we investigated the potential causal relationship between circulating metabolites and chalazion using two-sample Mendelian randomization (MR) analysis.Methods: For the primary analysis, 249 metabolic biomarkers were obtained from the UK Biobank, and 123 circulating metabolites were obtained from the publication by Kuttunen et al. for the secondary analysis. Chalazion summary data were obtained from the FinnGen database. Inverse variance weighted (IVW) is the main MR analysis method, and the MR assumptions were evaluated in sensitivity and colocalization analyses.Results: Two MR analyses results showed that the common metabolite, alanine, exhibited a genetic protective effect against chalazion (primary analysis: odds ratio [OR] = 0.680; 95% confidence interval [CI], 0.507–0.912; p = 0.010; secondary analysis: OR = 0.578; 95% CI, 0.439–0.759; p = 0.00008). The robustness of the findings was supported by heterogeneity and horizontal pleiotropy analysis. Two colocalization analyses showed that alanine did not share a region of genetic variation with chalazion (primary analysis: PPH4 = 1.95%; secondary analysis: PPH4 = 25.3%). Moreover, previous studies have suggested that an increase in the degree of unsaturation is associated with an elevated risk of chalazion (OR = 1.216; 95% CI, 1.055–1.401; p = 0.007), with omega-3 fatty acids (OR = 1.204; 95% CI, 1.054–1.377; p = 0.006) appearing to be the major contributing factor, as opposed to omega-6 fatty acids (OR = 0.850; 95% CI, 0.735–0.982; p = 0.027).Conclusion: This study suggests that alanine and several unsaturated fatty acids are candidate molecules for mechanistic exploration and drug target selection in chalazion.
Case report: Simultaneous measurement of intracranial pressure and lumbar intrathecal pressure during epidural patch therapy for treating spontaneous intracranial hypotension syndrome. Spontaneous intracranial hypotension or spontaneous intraspinal hypovolume?
Authors: Engrand Nicolas , Salardaine Quentin , Desilles Jean-Philippe , Echard Cécile , Bourdillon Pierre , Williams Marc , Baille Guillaume 
Published: March 2024

ObjectivesSpontaneous intracranial hypotension (SIH) is frequently complicated by subacute subdural hematoma (SDH) and more rarely by bilateral thalamic ischemia. Here, we report a case of SIH-related SDH treated with three epidural patches (EPs), with follow-up of the intracranial pressure and lumbar intrathecal pressure.MethodsA 46-year-old man presented bilateral thalamic ischemia, then a growing SDH. After failure of urgent surgical evacuation, he underwent three saline EPs, two dynamic myelography examinations and one digital subtraction angiography–phlebography examination. However, because of no dural tear and no obstacle to the venous drainage of the vein of Galen, no therapeutic procedure was available, and the patient died.ResultsThe case exhibited a progressive increase in the transmission of lumbar intrathecal pressure to intracranial pressure during the three EPs. The EPs may have successfully treated the SIH, but the patient did not recover consciousness because of irreversible damage to both thalami.ConclusionClinicians should be aware of the bilateral thalamic ischemia picture that may be the presenting sign of SIH. Moreover, the key problem in the pathophysiology of SIH seems to be intraspinal and intracranial volumes rather than pressures. Therefore, intracranial hypotension syndrome might actually be an intraspinal hypovolume syndrome.
Autosomal recessive primary microcephaly type 2 associated with a novel WDR62 splicing variant that disrupts the expression of the functional transcript
Authors: Chen Haizhu , Zheng Ying , Wu Hua , Cai Naiqing , Xu Guorong , Lin Yi , Li Jin-Jing 
Published: March 2024

BackgroundAutosomal recessive primary microcephaly (MCPH) is a rare neurodevelopmental disorder characterized primarily by congenital microcephaly and intellectual disability but without extra-central nervous system malformations. This investigation aimed to elucidate the genetic underpinnings of microcephaly in a patient from a Chinese consanguineous family.MethodsA comprehensive clinical assessment, including brain magnetic resonance imaging (MRI), electroencephalogram (EEG), and genetic analyses, was conducted to evaluate the patient’s condition. Whole-exome sequencing (WES) was employed to identify the causative gene, followed by Sanger sequencing, to confirm the mutation and its segregation within the family. Reverse transcript polymerase chain reaction (RT-PCR) was utilized to detect changes in splicing. Western blot was employed to reveal the difference of protein expression level between the wild-type and mutant WDR62 in vitro.ResultsThe patient exhibited classic MCPH symptoms, including microcephaly, recurrent epilepsy, delayed psychomotor development, and intellectual disability. Additionally, asymmetrical limb length was noted as a prominent feature. MRI findings indicated reduced brain volume with cortical malformations, while EEG demonstrated heightened sharp wave activity. A molecular analysis uncovered a novel homozygous variant c.4154–6 C &gt; G in the WDR62 intron, and a functional analysis confirmed the pathogenicity of this mutation, resulting in the formation of an abnormal transcript with premature termination codons.ConclusionThis study enhances our understanding of the genetic heterogeneity associated with MCPH and highlights the pivotal role of genetic testing in the diagnosing and managing of rare neurodevelopmental disorders. Furthermore, it highlights the potential of emerging genetic therapies in treating conditions such as MCPH2.
Brain serotonin and serotonin transporter expression in male and female postnatal rat offspring in response to perturbed early life dietary exposures
Authors: Ye Xin , Ghosh Shubhamoy , Shin Bo-Chul , Ganguly Amit , Maggiotto Liesbeth , Jacobs Jonathan P. , Devaskar Sherin U. 
Published: March 2024

IntroductionSerotonin (5-HT) is critical for neurodevelopment and the serotonin transporter (SERT) modulates serotonin levels. Perturbed prenatal and postnatal dietary exposures affect the developing offspring predisposing to neurobehavioral disorders in the adult. We hypothesized that the postnatal brain 5-HT-SERT imbalance associated with gut dysbiosis forms the contributing gut-brain axis dependent mechanism responsible for such ultimate phenotypes.MethodsEmploying maternal diet restricted (IUGR, n=8) and high fat+high fructose (HFhf, n=6) dietary modifications, rodent brain serotonin was assessed temporally by ELISA and SERT by quantitative Western blot analysis. Simultaneously, colonic microbiome studies were performed.ResultsAt early postnatal (P) day 2 no changes in the IUGR, but a ~24% reduction in serotonin (p = 0.00005) in the HFhf group occurred, particularly in the males (p = 0.000007) revealing a male versus female difference (p = 0.006). No such changes in SERT concentrations emerged. At late P21 the IUGR group reared on HFhf (IUGR/HFhf, (n = 4) diet revealed increased serotonin by ~53% in males (p = 0.0001) and 36% in females (p = 0.023). While only females demonstrated a ~40% decrease in serotonin (p = 0.010), the males only trended lower without a significant change within the HFhf group (p = 0.146). SERT on the other hand was no different in HFhf or IUGR/RC, with only the female IUGR/HFhf revealing a 28% decrease (p = 0.036). In colonic microbiome studies, serotonin-producing Bacteriodes increased with decreased Lactobacillus at P2, while the serotonin-producing Streptococcus species increased in IUGR/HFhf at P21. Sex-specific changes emerged in association with brain serotonin or SERT in the case of Alistipase, Anaeroplasma, Blautia, Doria, Lactococcus, Proteus, and Roseburia genera.Discussion We conclude that an imbalanced 5-HT-SERT axis during postnatal brain development is sex-specific and induced by maternal dietary modifications related to postnatal gut dysbiosis. We speculate that these early changes albeit transient may permanently alter critical neural maturational processes affecting circuitry formation, thereby perturbing the neuropsychiatric equipoise.