bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peripheral, but Not Central, CB1 Antagonism Provides Food Intake–Independent Metabolic Benefits in Diet-Induced Obese Rats
Authors: Nogueiras Ruben , Veyrat-Durebex Christelle , Suchanek Paula M. , Klein Marcella , Tschöp Johannes , Caldwell Charles , Woods Stephen C. , Wittmann Gabor , Watanabe Masahiko , Liposits Zsolt , Fekete Csaba , Reizes Ofer , Rohner-Jeanrenaud Francoise , Tschöp Matthias H. 
Published: August 2008

OBJECTIVE—Blockade of the CB1 receptor is one of the promising strategies for the treatment of obesity. Although antagonists suppress food intake and reduce body weight, the role of central versus peripheral CB1 activation on weight loss and related metabolic parameters remains to be elucidated. We therefore specifically assessed and compared the respective potential relevance of central nervous system (CNS) versus peripheral CB1 receptors in the regulation of energy homeostasis and lipid and glucose metabolism in diet-induced obese (DIO) rats.RESEARCH DESIGN AND METHODS—Both lean and DIO rats were used for our experiments. The expression of key enzymes involved in lipid metabolism was measured by real-time PCR, and euglycemic-hyperinsulinemic clamps were used for insulin sensitivity and glucose metabolism studies.RESULTS—Specific CNS-CB1 blockade decreased body weight and food intake but, independent of those effects, had no beneficial influence on peripheral lipid and glucose metabolism. Peripheral treatment with CB1 antagonist (Rimonabant) also reduced food intake and body weight but, in addition, independently triggered lipid mobilization pathways in white adipose tissue and cellular glucose uptake. Insulin sensitivity and skeletal muscle glucose uptake were enhanced, while hepatic glucose production was decreased during peripheral infusion of the CB1 antagonist. However, these effects depended on the antagonist-elicited reduction of food intake.CONCLUSIONS—Several relevant metabolic processes appear to independently benefit from peripheral blockade of CB1, while CNS-CB1 blockade alone predominantly affects food intake and body weight.
Sharpless Asymmetric Dihydroxylation of Olefins in WaterSurfactant Media with Recycling of the Catalytic System by Membrane Nanofiltration
Authors: Branco Luis C. , Ferreira Frederico Castelo , Santos José L. , Crespo João G. , Afonso Carlos A. M. 
Published: August 2008

AbstractThis paper presents a new and more sustainable alternative approach for the Sharpless catalytic asymmetric dihydroxylation (AD) of olefins using a water/surfactant system as reaction media. The AD reaction was performed using several cationic and anionic surfactants allowing yields and enantiomeric excesses higher or comparable with the conventional systems (using organic mixtures). The use of this water/surfactant medium offers the additional advantage of performing the reactions without the need of a slow addition of olefins. Asymmetric dihydroxylation of 1‐hexene in a 1.5 mM sodium cholate aqueous solution, using N‐methylmorpholine N‐oxide (NMO) as co‐oxidant was selected as model system to evaluate the feasibility of recycling the Sharpless catalytic system by nanofiltration. The reaction media was processed by nanofiltration, the product was isolated in the permeate, whereas the catalytic system and surfactant were retained by the membrane and recycled through six successive reactions, improving the catalyst turn‐over number. The experimental results were compared with the ones calculated on the basis of mass balances, membrane rejections to product and reaction yields.
Multicenter prospective trial evaluating the tolerability of imatinib for Japanese patients with chronic myelogenous leukemia in the chronic phase: Does body weight matter?
Authors: Kanda Yoshinobu , Okamoto Shinichiro , Tauchi Tetsuzo , Kizaki Masahiro , Inokuchi Koiti , Yabe Mariko , Yokoyama Kenji , Ito Yoshikazu , Kimura Yukihiko , Higashihara Masaaki , Bessho Masami , Ando Kiyoshi , Chiba Shigeru , Kurokawa Mineo , Oshimi Kazuo , Dan Kazuo , Ohyashiki Kazuma , Ikeda Yasuo 
Published: August 2008

AbstractImatinib at a daily dose of 400 mg is the standard treatment for chronic myelogenous leukemia in the chronic phase. However, the feasibility of this dose for small Japanese adults has not been clarified. We prospectively investigated the toxicity and efficacy of this dose in adult Japanese patients. Among the 89 evaluable patients with a median body weight of 62.8 kg, imatinib therapy was held in 40 subjects (45%), due to Grade 3–4 toxicities in 30 patients (75%) and Grade 2 toxicities at the discretion of the attending physician in 10 patients (25%). However, treatment was resumed and the dose was gradually increased until 62 of the 89 patients tolerated a maintenance dose of 400 mg. Older age and lower body weight were significant independent risk factors for discontinuation of imatinib. After a median follow‐up period of 31 months, 84 patients were alive without progression. The complete cytogenetic response rate was 60 and 90% at 6 months and 1 year after starting imatinib, respectively. Older patients and those with a lower body weight were less likely to achieve a complete cytogenetic response. These findings suggest that the body weight has a significant influence on the toxicity and efficacy of imatinib in patients with a small body size, although dose reduction in proportion to weight may result in an inadequate response to imatinib. Am. J. Hematol., 2008. © 2008 Wiley‐Liss, Inc.
In vitro sodium nitroprusside‐mediated toxicity towards Leishmania amazonensis promastigotes and axenic amastigotes
Authors: Genestra Marcelo , Soares‐Bezerra Rômulo José , Gomes‐Silva Liliane , Fabrino Daniela Leite , Bellato‐Santos Thiago , Castro‐Pinto Denise Barçante , Canto‐Cavalheiro Marilene Marcuzzo , Leon Leonor L. 
Published: August 2008

AbstractLeishmania parasites survive despite exposure to the toxic nitrosative oxidants during phagocytosis by the host cell. In this work, the authors investigated comparatively the resistance of Leishmania amazonensis promastigotes and axenic amastigotes to a relatively strong nitrosating agent that acts as a nitric oxide (NO) donor, sodium nitroprusside (SNP). Results demonstrate that SNP is able to decrease, in vitro, the number of L. amazonensis promastigotes and axenic amastigotes in a dose‐dependent maner. Promastigotes, cultured in the presence of 0.25, 0.5, and 1 mmol L−1 SNP for 24 h showed about 75% growth inhibition, and 97–100% when the cultures were treated with >2 mmol L−1 SNP. In contrast, when axenic amastigotes were growing in the presence of 0.25–8 mM SNP added to the culture medium, 50% was the maximum of growth inhibition observed. Treated promastigotes presented reduced motility and became round in shape further confirming the leishmanicidal activity of SNP. On the other hand, axenic amastigotes, besides being much more resistant to SNP‐mediated cytotoxicity, did not show marked morphological alteration when incubated for 24 h, until 8 mM concentrations of this nitrosating agent were used. The cytotoxicity toward L. amazonensis was attenuated by reduced glutathione (GSH), supporting the view that SNP‐mediated toxicity triggered multiple oxidative mechanisms, including oxidation of thiols groups and metal‐independent oxidation of biomolecules to free radical intermediates. Copyright © 2008 John Wiley & Sons, Ltd.
ChemInform Abstract: Rare Earth Metal‐Rich Indides Ln14Rh3‐xIn3 (Ln: Y, Dy, Ho, Er, Tm, Lu).
Authors: Zaremba Roman , Poettgen Rainer 
Published: August 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Crystal Chemistry and Thermodynamic Properties of Anisotropic Ce2Ni7H4.7 Hydride.
Authors: Denys R. V. , Yartys V. A. , Sato Masashi , Riabov A. B. , Delaplane R. G. 
Published: August 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Crystal Growth and Optical Spectroscopic Characterization of the Ytterbium‐Doped Laser Molybdate Yb—Li3Gd3Ba2 (MoO4)8.
Authors: Garcia‐Cortes Alberto , Cascales Concepcion 
Published: August 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Structural and Physical Properties of Mg3‐xZnxSb2 (x = 0—1.34).
Authors: Ahmadpour Faraz , Kolodiazhnyi Taras , Mozharivskyj Yurij 
Published: August 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and CO2 Capture Evaluation of Li2‐xKxZrO3 Solid Solutions and Crystal Structure of a New Lithium—Potassium Zirconate Phase.
Authors: Veliz‐Enriquez Mayra Y. , Gonzalez Gonzalo , Pfeiffer Heriberto 
Published: August 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Reaction Dynamics of the Decaniobate Ion [HxNb10O28](6‐x)‐ in Water.
Authors: Villa Eric M. , Ohlin C. Andre , Balogh Edina , Anderson Travis M. , Nyman May D. , Casey William H. 
Published: August 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The First Silicon‐Based Cationic Clathrate III with High Thermal Stability: Si172‐xPxTey (x = 2y, y < 20).
Authors: Zaikina Julia V. , Kovnir Kirill A. , Haarmann Frank , Schnelle Walter , Burkhardt Ulrich , Borrmann Horst , Schwarz Ulrich , Grin Yuri , Shevelkov Andrei V. 
Published: August 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Characterization of Layered γ‐Titanium Phosphate (C2H5NH3) [Ti(H1.5PO4)(PO4)] 2×H2O Intercalate: A Combined NMR, Synchrotron XRD, and DFT Calculations Study.
Authors: Mafra Luis , Rocha Joao , Fernandez Christian , Castro German R. , Garcia‐Granda Santiago , Espina Aranzazu , Khainakov Sergei A. , Garcia Jose R. 
Published: August 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Characterization of Bi5Nb3O15 by Refinement of Neutron Diffraction Pattern, Acid Treatment and Reaction of the Acid‐Treated Product with n‐Alkylamines.
Authors: Tahara Seiichi , Shimada Akira , Kumada Nobuhiro , Sugahara Yoshiyuki 
Published: August 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Modular Construction of Oxide Structures—Compositional Control of Transition Metal Coordination Environments.
Authors: Tenailleau Christophe , Allix Mathieu , Claridge John B. , Hervieu Maryvonne , Thomas Michael F. , Hirst James P. , Rosseinsky Matthew J. 
Published: August 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Pentafluorophenyl Group as a Module for the Direct Modification of Chiral Diamines for Asymmetric Catalysis.
Authors: Korenaga Toshinobu , Nomura Kenji , Minami Shinichi , Sasaki Hitomi , Sakai Takahashi 
Published: August 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of New Pyrrolo[3,4‐c]isoxazole, Pyrrolo[2,3‐d][1,2,3]triazole, Triazolo[4,5‐c]pyridazine, and Dipyrrolo[3,2‐b:3′,4′‐d]pyran Derivatives.
Authors: Amer F. A. , Hammouda M. , El‐Ahl A.‐A. S. , Abdel‐Wahab B. F. 
Published: August 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Wet Carbon‐Based Solid Acid/Potassium Bromate as an Efficient Heterogeneous Reagent for Oxidation of Alcohols under Mild Conditions.
Authors: Zali Abbas , Shokrolahi Arash 
Published: August 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Catalytic Enantioselective Conjugate Addition of Cyanide to Enones.
Authors: Tanaka Yuta , Kanai Motomu , Shibasaki Masakatsu 
Published: August 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Application of Odorless Thiols for the Cleavage of 2‐ and 4‐Nitrobenzenesulfonamides.
Authors: Matoba Manabu , Kajimoto Tetsuya , Node Manabu 
Published: August 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Solvent‐Free Passerini Reactions.
Authors: Koszelewski Dominik , Szymanski Wiktor , Krysiak Joanna , Ostaszewski Ryszard 
Published: August 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Partial Oxidation of Alkenylsilanes with Ozone: A Novel Stereoselective Approach to the Diol and Triol Derivatives.
Authors: Igawa Kazunobu , Sakita Kyohei , Murakami Masanori , Tomooka Katsuhiko 
Published: August 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: One‐Pot, Three‐Step Preparation of Alkyl and Aryl Alkylcarbamates from S‐Methyl N‐Alkylthiocarbamates.
Authors: Artuso Emma , Degani Iacopo , Fochi Rita , Magistris Claudio 
Published: August 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Palladium‐Catalyzed Monoamination of Dihalogenated Benzenes.
Authors: Larsen Simon Birksoe , Bang‐Andersen Benny , Johansen Tommy Noerskov Johansen , Joergensen Morten 
Published: August 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: CAN‐Mediated Oxidation of Electron‐Deficient Aryl and Heteroaryl Hydrazines and Hydrazides.
Authors: Stefane Bogdan , Polanc Slovenko 
Published: August 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Biomimetic Transfer Hydrogenation of 2‐Alkoxy‐ and 2‐Aryloxyketones with Iron—Porphyrin Catalysts.
Authors: Enthaler Stephan , Spilker Bjoern , Erre Giulia , Junge Kathrin , Tse Man Kin , Beller Matthias 
Published: August 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Acyloins from Morita—Baylis—Hillman Adducts: An Alternative Approach to the Racemic Total Synthesis of Bupropion.
Authors: Amarante Giovanni W. , Rezende Patricia , Cavallaro Mayra , Coelho Fernando 
Published: August 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A New Silicon Lewis Acid for Highly Enantioselective Mannich Reactions of Aliphatic Ketone‐Derived Hydrazones.
Authors: Notte Gregory T. , Leighton James L. 
Published: August 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: CeCl3×7H2O: An Effective Additive in Ru‐Catalyzed Enantioselective Hydrogenation of Aromatic α‐Ketoesters.
Authors: Meng Qinghua , Sun Yanhui , Ratovelomanana‐Vidal Virginie , Genet Jean Pierre , Zhang Zhaoguo 
Published: August 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Silica‐Supported Tetramethylguanidine: An Efficient Solid Base for Aldol‐Type Coupling of Aldehydes with Ethyl Diazoacetate.
Authors: Likhar Pravin R. , Roy Sarabindu , Roy Moumita , Subhas M. S. , Kantam M. Lakshmi 
Published: August 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: An Efficient Total Synthesis of a Sphingosine‐1‐phosphate Receptor Agonist KRP‐203,
Authors: Chino Masao , Kiuchi Masatoshi , Adachi Kunitomo 
Published: August 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Efficient Iron‐Catalyzed Sakurai—Michael Addition of Allyltrimethylsilane to Chalcones.
Authors: Xu Li‐Wen , Yang Ming‐Song , Qiu Hua‐Yu , Lai Guo‐Qiao , Jiang Jian‐Xiong 
Published: August 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A One‐Pot Stereoselective Synthesis of trans‐1‐Aryl‐2‐aminotetralins from 2‐Arylethyl Styrenes.
Authors: Hajra Saumen , Maji Biswajit , Sinha Debarshi , Bar Sukanta 
Published: August 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Alumina Sulfuric Acid: An Efficient Heterogeneous Catalyst for the Synthesis of Amidoalkyl Naphthols
Authors: Shaterian Hamid R. , Hosseinian Asghar , Yarahmadi Hossein , Ghashang Majid 
Published: August 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Efficient Synthesis of 3‐Iodoindenes via Lewis Acid Catalyzed Friedel—Crafts Cyclization of Iodinated Allylic Alcohols.
Authors: Zhou Xiaobo , Zhang Huimin , Xie Xin , Li Yanzhong 
Published: August 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.