bluuebunny/crossref_metadata_2025_split huggingface dataset:
The human peripheral blood mononuclear cell proteome responds to a dietary flaxseed‐intervention and proteins identified suggest a protective effect in atherosclerosis
Authors: Fuchs Dagmar , Piller Regina , Linseisen Jakob , Daniel Hannelore , Wenzel Uwe 
Published: August 2007

AbstractFlaxseed is one of the richest sources of lignans that are converted to enterolactone by the intestinal microflora. Enterolactone has been suggested to be the prime active compound mediating atherosclerosis‐protective effects that were shown for flaxseed. The effects of a 1‐wk intervention with 0.4 g of flaxseed/kg body weight per day on enterolactone plasma levels in seven healthy men revealed that all participants (PAs) responded with enhanced enterolactone plasma levels. Proteome analysis of peripheral blood mononuclear cells (PBMC) from donors before, during, and after the intervention showed that flaxseed consumption affected significantly the steady‐state levels of 16 proteins of which four were altered in a similar manner when blood mononuclear cells were exposed ex vivo to enterolactone. Enhanced levels of peroxiredoxin and reduced levels of the long‐chain fatty acid β‐oxidation multienzyme complex may be taken as indicators of a reduced oxidative stress whereas reduced levels of glycoprotein IIIa/II could indicate improved protection from thrombotic and inflammatory processes. In conclusion, the blood mononuclear cell proteome responds to dietary flaxseed intake with changes in a number of atherosclerosis‐relevant proteins that may be taken as biomarkers of exposure and some of these changes observed can be attributed to the action of the lignan metabolite enterolactone.
Antibody screening database for protein kinetic modeling
Authors: Spurrier Brett , Washburn Frank L. , Asin Samuel , Ramalingam Sundhar , Nishizuka Satoshi 
Published: August 2007

AbstractKnowledge‐based proteomic studies rely on the availability of quality antibodies. The increasing number of commercially available antibodies covers a wide range of protein networks; however, performance of each antibody can vary, depending on what type of cells, treatments, and time points are studied. Here, we describe an antibody database in which we screened 279 antibodies against multiple cell lysates after various treatments and from different time points. We applied these quality‐confirmed antibodies on protein arrays, showing their utility for protein kinetic modeling.
Proteomic profiling of chronic low‐frequency stimulated fast muscle
Authors: Donoghue Pamela , Doran Phil , Wynne Kieran , Pedersen Kasper , Dunn Michael J. , Ohlendieck Kay 
Published: August 2007

AbstractSkeletal muscle fibre transitions occur in many biological processes, in response to alterations in neuromuscular activity, in muscular disorders, during age‐induced muscle wasting and in myogenesis. It was therefore of interest to perform a comprehensive proteomic profiling of muscle transformation. Chronic low‐frequency stimulation of the rabbit tibialis anterior muscle represents an established model system for studying the response of fast fibres to enhanced neuromuscular activity under conditions of maximum activation. We have conducted a DIGE analysis of unstimulated control specimens versus 14‐ and 60‐day conditioned muscles. A differential expression pattern was observed for 41 protein species with 29 increased and 12 decreased muscle proteins. Identified classes of proteins that are changed during the fast‐to‐slow transition process belong to the contractile machinery, ion homeostasis, excitation–contraction coupling, capillarization, metabolism and stress response. Results from immunoblotting agreed with the conversion of the metabolic, regulatory and contractile molecular apparatus to support muscle fibres with slower twitch characteristics. Besides confirming established muscle elements as reliable transition markers, this proteomics‐based study has established the actin‐binding protein cofilin‐2 and the endothelial marker transgelin as novel biomarkers for evaluating muscle transformation.
Telephone prompts and psychiatry attendance rates
Authors: Krishna Murali , Sharma Vimal , Sadasivan Asha 
Published: August 2007

AbstractHigh non‐attendance rates are an ongoing problem in psychiatric clinics. The authors describe their study that investigated the effect of telephone prompts on attendance rates at a community mental health centre. They discuss their findings in the context of other studies and consider the variation in attendance rates among different patient groups. Copyright © 2007 Wiley Interface Ltd
Getting the measure of the impact of NAbs in MS
Authors: O'Connell Nicola 
Published: August 2007

AbstractThe European Federation of Neurological Societies (EFNS) guidelines on the use of anti‐interferon beta neutralising antibody measurements put the spotlight on the importance of neutralising antibodies (NAbs) in multiple sclerosis (MS) therapy, and the need for effective testing and monitoring. Freelance medical writer Nicola O'Connell looks at the impact of NAbs on the efficacy of MS treatment and at the options for measuring NAbs. Copyright © 2007 Wiley Interface Ltd
Do cholinesterase inhibitors alter the course of dementia?
Authors: Larner Andrew J 
Published: August 2007

AbstractCholinesterase inhibitors are generally believed to have solely symptomatic effects – the benefit being lost on termination of the drug. Dr Larner describes an audit carried out at his cognitive function clinic between 2001 and 2005 to investigate whether cholinesterase inhibitors can alter the natural history of dementia, by observing the number of patients entering nursing homes during the study period. Copyright © 2007 Wiley Interface Ltd
Primhe: Primary Care Mental Health & Education
Authors: Fisher Denise , Lyons Christina , Rossiter Roisin , Balls Makala 
Published: August 2007

AbstractPCGMHW workplace activity 12 months post‐qualifyingAn audit of the work of Primary Care Graduate Mental Health Workers (PCGMHWs) suggests they may be under‐utilised. Greater awareness of these new mental health workers and their role could mean improved access to care for greater numbers of people with mild to moderate mental health problems, reduced pressure on specialist secondary care mental health services and development of primary care mental health services.Bibliotherapy: The process of developing a Book Prescription SchemeThe increasing demand for access to psychological therapies within primary care has resulted in greater awareness of the potential benefits of utilising bibliotherapy and self‐help materials as part of a stepped care approach. Book prescription schemes are one example of how bibliotherapy can be applied within primary care mental health services. Roisin Rossiter and Makala Balls reflect on the process of developing a book prescription scheme within Buckinghamshire. Copyright © 2007 Wiley Interface Ltd
DC conductivity and spectroscopic characterization of binary dopant (ZrO2/AgI)‐doped polyaniline
Authors: Ameen Sadia , Ali Vazid , Zulfequar M. , Mazharul Haq M. , Husain M. 
Published: August 2007

AbstractBinary dopant mixture of (ZrO2/AgI) (v/v) is prepared in different ratios to enhance the conductivity of the synthesized PANI. DC conductivity of (ZrO2/AgI) (v/v) doped PANI samples is measured in the temperature range (300‐400K). The calculated values of pre‐exponential factor (σ0) indicates that conduction is taking place through hopping process due to localized states present near the Fermi level. Structural changes due to interaction of dopant species with PANI are studied through FT‐IR and Photoluminescence characterization. Photoluminescence (PL) spectra of the doped samples occurred in the form of peaks and the intensities of these peaks vary according to the concentration of dopant mixture. © 2007 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 45: 2682–2687, 2007
Longitudinal quantification of growth and changes in primary tracheobronchomalacia sites in children
Authors: Masters Ian B. , Zimmerman Paul V. , Chang Anne B. 
Published: August 2007

AbstractRationaleLongitudinal follow‐up of children with tracheobronchomalacia is essential to improving our understanding of these disorders, yet currently, there is no such data.ObjectivesTo longitudinally define malacia sites and quantify the cross‐sectional area (CSA) of the lumen using a bronchoscopic technique and to relate these measurements to illness profiles.MethodsThe validated color histogram mode technique was utilized to quantify primary malacia lesions and airway sites' CSA. Illness frequency, validated scales of illness and cough diary scores were prospectively used to assess clinical profiles.ResultsThirty‐five malacia sites were defined from the 2 studies of 21 children. CSA of 21 (60%) of the malacia lesions increased, 5 (14%) new lesions appeared, 5 (14%) decreased in size, 3 (8%) remained unchanged, and 1(3%) was indeterminate. Overall there was no statistically significant change in paired‐data assessments of malacia sites' area while there was a significant increase in area of non‐malacia sites. The median yearly growth rate for the malacia sites and non‐malacia was 3.65 mm2/year sites and 5.38 mm2/year, respectively (P = 0.31). The type and severity of lesion was not associated with any difference in growth rates, illness frequency or clinical scores.ConclusionsMalacia lesions increase in size at the same rate as non‐malacia sites. However malacia may worsen and new primary lesions may develop. Neither malacia type nor severity influences their growth pattern or illness profile. Pediatr Pulmonol. 2007; 42:906–913. © 2007 Wiley‐Liss, Inc.
Erratum: Preferential chemosensitization of PTEN‐mutated prostate cells by silencing the Akt kinase
Authors: Priulla Marcella , Calastretti Angela , Bruno Paola , Azzariti Amalia , Paradiso Angelo , Canti Gianfranco , Nicolin Angelo 
Published: August 2007

AbstractWhen originally published, Amalia Azzariti's name appeared incorrectly in the byline. Her name appears correctly in the above.The original article to which this erratum refers was published in The Prostate 2007;67(7):782–789.
Preparation, characterization and conductivity studies of a Nasicon system Ag3–2xTax Al2–x (PO4)3 (x = 0.6–1.4)
Authors: Rambabu G. , Anantharamulu N. , Koteswara Rao K. , Sarma J. A. R. P. , Vithal M. 
Published: August 2007

AbstractRhombohedral Nasicon type materials of composition Ag3–2x Tax Al2–x (PO4)3 (x = 0.6, 0.7,0.8, 0.9, 1.0, 1.1,1.2, 1.3 and 1.4) have been prepared and characterized by powder XRD and IR. All these compositions are found to be isomorphous with NbTiP3O12, lithium and sodium analogues of same Nasicon framework. The unit cell parameters were derived from powder XRD. All the compounds show characteristic PO4 vibrational bands. DC conductivity measurements were carried out in the temperature range 300–650 K. The activation energies for conduction were deduced from the Arrhenius plots and are in the range 0.42–0.71 eV. Among the series investigated, Ag0.8Ta1.1Al0.9P3O12 exhibits the highest conductivity, σ ≈ 5.01 × 10–3 S cm–1 at 350 °C (Ea = 0.55 eV). (© 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Effect of B2O3 addition to the LNT ceramic composite on sintering behavior and microwave dielectric properties
Authors: Zeng Qun , Li Wei , Shi Jian‐lin , Dong Xian‐lin , Guo Jing‐kun 
Published: August 2007

AbstractThe effects of the addition B2O3 on the sintering behavior, microstructure and microwave dielectric properties of 5Li2O–1Nb2O5–5TiO2 (LNT) ceramics have been investigated. With low‐level doping of B2O3 (≤2 wt%), the LNT ceramics could be fully densified at around 900 °C without much degradation in microwave dielectric properties. Similar structures and microwave dielectric properties could be obtained for the densified 1–2 wt% B2O3‐doped ceramics. The 1 wt% B2O3‐doped ceramics sintered at 900 °C have better microwave dielectric properties of εr = 41.2, Q × f = 9320 GHz (at 4.66 GHz), τf = 42 ppm/°C. The LNT ceramics could be applied in multilayer microwave devices requiring low sintering temperatures. (© 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Hydrogen concentration and bonding in nano‐diamond films of varying grain sizes grown by different chemical vapor deposition methods
Authors: Michaelson Sh. , Ternyak O. , Akhvlediani R. , Williams O. A. , Gruen D. , Hoffman A. 
Published: August 2007

AbstractHydrogen in a variety of forms (molecular hydrogen, atomic hydrogen, hydrocarbon radicals) is involved in diamond formation. The present work studies the incorporation of hydrogen and its bonding configuration in diamond films composed of diamond grains of varying size which were deposited by three different methods: hot filament (HF), micro wave (MW) and direct current glow discharge (dc GD) chemical vapor deposition (CVD). The size of diamond grains which constitute the films varies in the following way: hundreds of nm in the case of HF CVD (∼300 nm), tens nm in the case of MW CVD (3–30 nm) and a few nm in the case of dc GD CVD (∼5 nm). Raman spectroscopy, secondary ion mass spectroscopy (SIMS) and high resolution electron energy loss spectroscopy (HR‐EELS) were applied to investigate the hydrogen trapping in the films. The retention of hydrogen in the films increases with decreasing grain size, indicating that most likely hydrogen is bonded and trapped in grain boundaries as well as on the films surfaces. Raman and HR‐EELS analysis show that hydrogen is bonded to sp2‐ and sp3‐hybridized carbon, giving rise to typical C–H vibration modes. (© 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Modelling the effect of doping metallic carbon nanotubes on their ability to transfer‐dope diamond
Authors: Sque Stephen J. , Ewels Christopher P. , Jones Robert , Briddon Patrick R. 
Published: August 2007

AbstractPrevious theoretical work indicates that carbon nanotubes (CNTs) may, like C60 and C60Fx, act as transfer dopants for diamond; that is, they are capable of extracting electrons from a hydrogen‐terminated diamond substrate, effectively doping the near‐surface region of the diamond p‐type. In the present study, the effect of functionalising/doping the CNTs on their electron‐extraction efficiency has been investigated, using ab‐initio density‐functional theory. Pristine, fluorine‐doped, and potassium‐doped (8,8) CNTs have been modelled both in isolation and lying prone on the (001)–(2 × 1):H surface of diamond. The total energies of the relaxed systems suggest that the CNTs are positively bound to the diamond substrate, while the structures and charge densities indicate that only physisorption has occurred. The electronic band structures are indicative of an enhanced electron transfer following fluorination of the CNT, while potassium doping of the CNT has destroyed the transfer‐doping effect. (© 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Multi‐impurity complexes for n‐type diamond: a computational study
Authors: Eyre R. J. , Goss J. P. , Briddon P. R. , Wardle M. G. 
Published: August 2007

AbstractDoping of diamond using multi‐component, multi‐species structures has been modelled using density functional methods. We find that few combinations of impurities yield donor levels shallower than phosphorus. Complexes involving impurities from the second or lower rows of the periodic table are unbound, and those involving the soluble element nitrogen can often be arranged in passive or even compensating geometries. (© 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Transfer doping of diamond via 2,3‐dichloro‐5,6‐dicyano‐1,4‐benzoquinone (DDQ)
Authors: Goss J. P. , Eyre R. J. , Briddon P. R. 
Published: August 2007

AbstractHydrogen terminated diamonds exposed to atmosphere typically exhibit surface p‐type conduction, thought to be due to transfer doping with holes in the surface valence band and negatively charged counter‐ions in an adsorbed layer. The effect has been demonstrated with atmospheric contamination forming an aqueous layer, and by C60 molecules. In this paper we show using first‐principles computational methods that organic layers made up from DDQ molecules may also be a candidate for inducing holes in the diamond surface. The effect appears independent of surface orientation and surface coverage. (© 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Microscopic diagnostics of DNA molecules on mono‐crystalline diamond
Authors: Rezek Bohuslav , Shin Dongchan , Uetsuka Hiroshi , Nebel Christoph E. 
Published: August 2007

AbstractDetailed data about deoxyribonucleic acid (DNA) attachment, arrangement, density and functionality on mono‐crystalline diamond surfaces are obtained by direct measurements in electrolytic solutions using fluorescence microscopy and atomic force microscopy in various regimes (oscillating, contact, phase, and surface potential imaging) and by fitting the data into a microscopic geometrical model of DNA. DNA is immobilized on undoped and boron‐doped diamonds with hydrogen and oxygen surface terminations which were functionalized by aminodecene and nitrofenyl linker molecules. The data show that, except photochemically processed oxidized diamond surfaces, the DNA molecules are covalently linked to diamond in a 65–92 Å thin and highly dense layers (6 × 1012 molecules/cm2) with sub‐nanometer intermolecular spacing and a strong tilt of 31° with respect to the surface. Ordering of these DNA layers shows only a weak (<10%) response to a change of buffer salinity in the range of 1–300 mM. The data are discussed with view to biosensor applications. (© 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Modeling of plasmonic nanostructures: Green's function integral equation methods
Authors: Søndergaard T. 
Published: August 2007

AbstractThree Green's function integral equation methods are considered for modeling of plasmonic nanostructures, namely the Green's tensor volume integral equation method (VIEM), the Green's tensor area integral equation method (AIEM), and the Green's function surface integral equation method (SIEM). Modeling of plasmonic nanostructures is challenging because of the large contrast between the involved materials, namely metals and dielectrics, sharp corners and edges with associated electric field singularities, and possibly plasmonic resonances. It was found that a standard discretization scheme based on cubic volume elements (VIEM) for a cylindrical gold scatterer or square area elements (AIEM) for a silver cylinder did not work, which is related to the stair‐cased description of the curved surfaces. In the case of the VIEM an alternative approach is studied based on ring volume elements and softening of sharp edges by using a gradual transition of the dielectric constant rather than having sharp interfaces. In the case of the AIEM special surface matching area elements are shown to drastically improve convergence. In the SIEM it is demonstrated that rounding of corners can be crucial for obtaining convergence in the case of a plasmonic resonance. The three methods are exemplified for a range of plasmonic nanostructures, namely the surface plasmon polariton bandgap structure with a bent waveguide channel, the long‐range surface plasmon polariton grating, and a metal nano‐strip resonator for short‐range surface plasmon polaritons. (© 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
HfO2/AlGaN/GaN structures with HfO2 deposited at ultra low pressure using an e‐beam
Authors: Tokranov V. , Rumyantsev S. L. , Shur M. S. , Gaska R. , Oktyabrsky S. , Jain R. , Pala N. 
Published: August 2007

AbstractWe show that HfO2/AlGaN/GaN structures with HfO2 layer deposited using an e‐beam in ultra high vacuum are suitable for field effect transistors. The dielectric constant of the HfO2 was found εHfO > 23–24, which is close to the highest re‐ ported values for this material. The leakage current did not exceed 10–4 A/cm2 at the threshold voltage. The comparison of the losses in the samples with and without HfO2 indicates low concentration of the interface traps. (© 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Erratum: Human sapoviruses: genetic diversity, recombination, and classification
Authors: Hansman Grant S. , Oka Tomoichiro , Katayama Kazuhiko , Takeda Naokazu 
Published: August 2007

AbstractReviews in Medical Virology 2007; 17: 133–141DOI: 10.1002/rmv.533It has come to our attention that there was an error contained in the above article within Figure 1 on page 134.In the figure the strain called Cruise ship is classified as GII/3, it should have been classified as GII/5.We apologise for this anomaly
Studying the separability relation between finite state machines
Authors: Spitsyna Natalia , El‐Fakih Khaled , Yevtushenko Nina 
Published: August 2007

AbstractSeveral authors have studied the relationships between non‐deterministic finite state machines (FSMs). These relationships can be used, for example, for deriving conformance tests from specifications represented by FSMs. In this paper, the separability relation between FSMs is studied. In particular, an algorithm is presented that derives a shortest separating sequence of two non‐deterministic FSMs. Given FSMs S with n states and T with m states, it is shown that the upper bound on the length of a shortest separating sequence is 2mn−1. Moreover, the upper bound is shown to be reachable. However, according to the conducted experiments, on average, the length of a shortest separating sequence of FSMs S and T states is less than mn and the existence of a separating sequence significantly depends on the number of non‐deterministic transitions in these FSMs. The proposed algorithm can also be used for deriving a separating sequence of two different states of a single FSM or for deriving a separating sequence of three or more FSMs. Copyright © 2007 John Wiley & Sons, Ltd.
On stochastic learning in predictive wireless ARQ
Authors: Kumar K. S. , Chandramouli R. , Subbalakshmi K. P. 
Published: August 2007

AbstractTraditional automatic repeat request (ARQ) protocols are channel unaware. That is, they react to channel errors by simply retransmitting erroneous packets and do not proactively decide whether or not to transmit a packet in a given slot based on past channel conditions. Clearly, ARQ protocols operating in this mode are not energy efficient. For example, continuously retransmitting erroneous packets when the wireless channel is in deep fade would cause significant wastage of transmission energy.In this paper, we present a stochastic learning automaton‐based wireless channel state aware ARQ protocol. The learning automaton learns to predict and track the time‐varying wireless channel conditions based on past observations. A Markov chain model for the channel state transitions is used. No a priori knowledge about the state transition probabilities is required by this predictor. Stochastic convergence of the learning algorithm is proved. The proposed ARQ protocol utilizes the predictions to compute transmission/retransmission policies in an online fashion. No pilot (training) symbols are used by the protocol for channel state prediction thereby avoiding any energy wastage due to the transmission of these symbols. Simulation results show that depending on the channel memory significant energy savings can be attained when compared with standard ARQ protocols. We also discuss the transmission energy versus delay trade‐off. Copyright © 2007 John Wiley & Sons, Ltd.