bluuebunny/crossref_metadata_2025_split huggingface dataset:
Literature and the Beauty of the World
Authors: Starobinski Jean 
Published: March 2007

When the world reveals a part of its beauty, what should our reaction be? How can we respond adequately? Is not our initial reaction one of a “discrepancy between our impressions and their habitual expression?” It is this question that Proust poses in one of the crucial passages early on in his masterpiece. Describing his walks along Méséglise's Way, and “the humble discoveries” he made there, the narrator details for us the overwhelming, decisive impression made on him by a shaft of sunlight:After an hour of rain and wind, against which I had struggled cheerfully, as I came to the edge of the Montjouvain pond, beside a little hut with a tiled roof in which M. Vinteuil's gardener kept his tools, the sun had just reappeared, and its golden rays, washed clean by the shower, glittered anew in the sky, on the trees, on the wall of the hut and the still wet tiles of the roof, on the ridge of which a hen was strutting. The wind tugged at the wild grass growing from cracks in the wall and at the hen's downy feathers, which floated out horizontally to their full extent with the unresisting submissiveness of light and lifeless things. The tiled roof cast upon the pond, translucent again in the sunlight, a dappled pink reflection which I had never observed before. And, seeing upon the water, and on the surface of the wall, a pallid smile responding to the smiling sky, I cried out aloud in my enthusiasm, brandishing my furled umbrella: “Gosh, gosh, gosh, gosh!” But at the same time I felt that I was in duty bound not to content myself with these unilluminating words, but to endeavor to see more clearly into the sources of my rapture.
Lost Paradigm or Inhibited Projects?
Authors: Michaux Bernard 
Published: March 2007

Who are we? Never have so many of us asked this question, nor so few been able to answer it. What is happening to us? Already we miss those who are not asking the question along with us.We all were sure of ourselves in our respective groups - some aggressive, others tolerant - but sure of being these ones and not those ones as we crossed paths with others or with us, in business and in war, and who were always ready to tell us which of all of them we were.
Human Rights and the Fate of Tolerance
Authors: Waterlot Ghislain 
Published: March 2007

The meanings of tolerance nowadays form a complex and ambiguous maze that far exceeds the scope of this essay. To clarify the following pages, however, we propose a preliminary distinction between original tolerance and modern tolerance.By original tolerance we mean the attitude that consists of putting up with, or not preventing, that which should not by law take place. It is motivated by prudence or condescension with regard to human failings. It is a sort of last resource. In any event, it is neither a permission nor an authorization: it is a favor, subject to revocation. As far back as one goes in human history, one finds traces of this elementary social practice.By modern tolerance, we mean the form of tolerance that has developed in modern times and is formulated by Castellion, Spinoza, Locke and in particular Pierre Bayle. To tolerate is to consent to the idea that in the name of freedom, in principle recognized by all, other men think and act according to principles that we do not share or with which we do not agree. In other words, tolerance is the corollary of freedom.
The Fathers of Sinology
Authors: Bresner Lisa 
Published: March 2007

Informing the Superior General of the Society of Jesus that the cornerstone of the Jesuit mission in China – that is, Father Matteo Ricci – had passed away on 3 May 1610, Father Pasio wrote:Fu servito Nostro Signore di chiamare al paradiso il buon P. Matteo Ricci, tanto antico nella Cina, e che accreditò molto la legge di Dio e la Compagnia con la sua santità, prudentia e patientia, aprendo il cammino agli altri Padri in quella folta selva di gentilità.Approximately three centuries later, a man whom Father Delattre unhesitatingly called “our indefatigable Sinologist” – Father Léon Wieger – also died on Chinese soil.
On Congo Cults of Bantu Origin in Cuba
Authors: Barnet Miguel 
Published: March 2007

Black Africans who were brought to Cuba as slaves represented a variety of origins and belonged to linguistic groups that were as divergent as their cultural backgrounds. A huge majority, however, originated in the Congo basin. The last officially recorded arrival of a slave ship in a Cuban port took place in 1873.It would be impossible to classify expressions of Bantu origin that were used in the slave trade. The arbitrary label “Congo” has been applied to most such expressions with a view to noting and suggesting a kinship with the cultural and religious heritage branching off from the Bantu linguistic trunk.
Biology Reinvigorated
Authors: Guille-Escuret Georges 
Published: March 2007

In fact, analogy is a legitimate form of comparison, and comparison is the only practical means we have for the understanding of things. The fault of the biological sociologists was not that they used it but that they used it wrongly. Instead of trying to control their studies of society by their knowledge of biol ogy, they tried to infer the laws of the first from the laws of the second.Émile Durkheim, 1898In order to establish itself as a discipline, it was not enough for sociology to disassociate itself from philosophy and psychology. The lines appearing in the above epigraph, published exactly one hundred years ago, remind us of what is often not considered in the difficulty of establishing social sciences in the world as a whole: first – and as a question of priority – disciplines had to fight the widely prevailing influence jointly held by evolutionism, “social Darwinism,” and “biological sociology” at the end of the nineteenth century. Durkheim's methodological warning thus contains something that elicits a “feeling of déjà vu” in us, with respect to some of the theoretical debates that the “scholarly community” puts forward today for the general public. Is this simply a superficial and somewhat coincidental similarity, or is it, rather, the rebirth of an idea?
Culture and Memory
Authors: Rupp-Eisenreich Britta 
Published: March 2007

“I shall attempt the analysis of memory … because memory in some form is presupposed in almost all other knowledge.”Bertrand Russell, The Analysis of Mind (1921)“Beginning with homo sapiens, the formation of an apparatus of social memory stands out as the foremost problem of human evolution.”André Leroi-Gourhan, Le Geste et la Parole (1965)Meme, Mneme, Mnemosyne: two neologisms, one dating from 1976 and the other from 1904, and the mythical figure personifying Memory from the time of the Titans - a strange primordial deity that the imagination brought forth even before the time of mortal men began. Her name is all that survived through the ages, yet this fleeting presence among the gods was just as consequential as a major figure like Prometheus. Could she have been conceived of as an indispensable condition for human beings to usher in the reign of culture?
Multiple sclerosis and brief moderate exercise. A randomised study
Authors: Bjarnadottir O.H. , Konradsdottir A.D. , Reynisdottir K. , Olafsson E. 
Published: March 2007

This is a randomised control study, to determine the effect of aerobic and strength exercise on physical fitness and quality of life in patients with mild multiple sclerosis (MS). Sixteen outpatients with definitive MS, aged 18-50, with an Expanded Disability Status Scale (EDSS) <4, completed the study. Every patient was evaluated according to physical fitness with peak oxygen consumption (V'O2peak ), workload and anaerobic threshold; quality of life (SF-36); and degree of disability (EDSS). The patients were then randomised to an exercise group (EG) (n =6) or a control group (CG) (n = 10). The EG exercised three times a week for five weeks, and the CG did not change their habits regarding exercise. In the EG, the mean change in workload was 0.34 W/kg (95% confidence interval (CI): 0.09-0.58), the mean change in V'O2peak was 4.54 mL/kg per minute (95% CI: 1.65-7.44), and the mean change in anaerobic threshold was 0.32 L/min (95% CI: 0.08-0.57). There was a tendency towards improved quality of life, and no change was detected in the degree of disability. This study confirms that brief, moderate, aerobic exercise improves physical fitness in individuals with mild MS. No evidence was found for worsening of MS symptoms in association with exercises. Multiple Sclerosis 2007; 13: 776-782. http://msj.sagepub.com
Clinical response to glatiramer acetate correlates with modulation of IFN-γ and IL-4 expression in multiple sclerosis
Authors: Valenzuela R.M. , Costello K. , Chen M. , Said A. , Johnson K.P. , Dhib-Jalbut S. 
Published: March 2007

Objective To determine whether glatiramer acetate (GA)-induced lymphoproliferation and IFN-γ and IL-4 modulation correlate with the clinical response in multiple sclerosis (MS). Background GA therapy involves the induction of anti-inflammatory cytokine shifts. However, it is not known whether this response correlates with the clinical outcome. Methods Thirty-six relapsing-remitting (RR) MS patients were treated with GA for at least two years, and classified clinically as GA-responders (GA-R=22) or hypo/non-responders (GA-HR/NR = 14). Proliferation of peripheral blood mononuclear cells (PBMC) to GA and Tetanus toxoid (TT), as well as IL-4 and IFN-γ ELISPOT, were performed. Findings There was no difference in PBMC proliferation to GA or TT between GA-R and GA-HR/NR before and during treatment (P>0.05). The mean number of IFN-γ ELISPOTS in unstimulated, TT and anti-CD3/CD28-stimulated PBMC was lower among GA-R (unstimulated: GA-R =10.1±6.21 (n=22) versus GA-HR/NR=17.8±12.7 (n=14), P=0.04; TT-GA-R =12.2±4.06 (n=12) versus GA-HR/NR=26.8±21.0 (n=8), P=0.028; anti-CD-3/CD28 GA-R=217.3±140.4 (n=22) versus GA-HR/NR=368.5±170.1 (n=14), P=0.006). In contrast, the number of IL-4 ELISPOTS remained unchanged in the GA-R group, but was progressively reduced in the GA-HR/NR group during GA therapy (GA-HR/NR IL-4: pre-Rx: 59±34 versus 22±11 at 12 months (n =6), P=0.0429). The IL-4/ IFN-γ ratio in anti-CD3/CD28-stimulated PBMC was significantly higher among GA-R compared to GA-HR/NR (P=0.0474). Interpretation Lymphoproliferation to GA did not differentiate GA-R from GA-HR/NR. However, reduced IFN-γ expression and stable IL-4 expression in anti-CD3/CD28-stimulated PBMC, and an increased IL-4/IFN-γ ratio was associated with favorable clinical response. More data are needed to validate the prospective use of IL-4/IFN-γ expression in PBMC as a biomarker of clinical response to GA for individual patients. Multiple Sclerosis 2007; 13: 754-762. http://msj.sagepub.com
Classification of patients with a clinically isolated syndrome based on signs and symptoms is supported by magnetic resonance imaging results
Authors: Nielsen J.M. , Moraal B. , Polman C.H. , Poppe P. , de Vos M. , Freedman M.S. , Kappos L. , Barkhof F. , Bauer L. , Pohl C. , Sandbrink R. , Hartung H.-P. , Uitdehaag B.M.J. 
Published: March 2007

Background Recently, a clinical classification system was described to determine whether symptoms and signs of patients presenting with a first episode suggestive of multiple sclerosis (MS) indicate the presence of monofocal or multifocal disease. Objectives To evaluate the value of this new classification system by comparing the results with those of simultaneously obtained magnetic resonance imaging (MRI) scans. Methods The 487 patients, randomised in the BENEFIT study, were centrally assessed using the new system and classified as monofocal or multifocal, based on clinical information by two neurologists masked for the MRI results. MRI analyses were performed by expert readers masked for the clinical classification. Results Patients classified as multifocal had more T2 hyperintense (median: 21 versus 15.5) and more T1 hypo-intense lesions (median: 2 versus 1) than those classified as monofocal. Patients classified at the local site as having evidence of a single clinical lesion, but reclassified centrally as having a clinical multifocal central nervous system presentation, had more T2 lesions than monofocal patients. In addition, patients with a multifocal presentation more often fulfilled the MRI criteria for dissemination in space, as incorporated in the International Panel (IP) diagnostic criteria for MS. Conclusion These data provide justification for the recently proposed clinical classification system to be used in patients who present with a first episode suggestive of MS, in that `multifocal', based on symptoms and signs, is associated with more lesions on MRI. Multiple Sclerosis 2007; 13: 717-721. http://msj.sagepub.com
Osteoprotegerin increases leukocyte adhesion to endothelial cells both in vitro and in vivo
Authors: Zauli Giorgio , Corallini Federica , Bossi Fleur , Fischetti Fabio , Durigutto Paolo , Celeghini Claudio , Tedesco Francesco , Secchiero Paola 
Published: March 2007

AbstractRecombinant osteoprotegerin (OPG) promoted the adhesion of both primary polymorphonuclear neutrophils (PMNs) and leukemic HL60 cells to endothelial cells. Leukocyte/endothelial cell adhesion was promoted by short (peak at 1 hour) preincubation of either endothelial cells or PMNs with OPG, and the peak of proadhesive activity was observed in the same range of OPG concentrations detected in the sera of patients affected by cardiovascular diseases. Although the cognate high-affinity ligands for OPG, membrane receptor activator of nuclear factor-κB ligand (RANKL) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), were detected at significant levels on both PMNs and HL60 cells, they were not expressed on the surface of endothelial cells. However, preincubation of OPG with heparin abrogated its proadhesive activity, whereas pretreatment of endothelial cells with chondroitinase plus heparinases significantly decreased the proadhesive activity of OPG. Taken together, these findings suggest the involvement of both the ligand binding and the N-terminal heparin-binding domains of OPG in mediating its pro-adhesive activity. The relevance of these in vitro findings was underscored by in vivo experiments, in which the topical administration of recombinant OPG increased leukocyte rolling and adhesion to rat mesenteric postcapillary venules. Our data suggest that a pathological increase of OPG serum levels might play an important role in promoting leukocyte/endothelial cell adhesion.
Decision Aids and Breast Cancer: Do They Influence Choice for Surgery and Knowledge of Treatment Options?
Authors: Waljee Jennifer F. , Rogers Mary A.M. , Alderman Amy K. 
Published: March 2007

Purpose To describe the effect of decision aids on the choice for surgery and knowledge of surgical therapy among women with early-stage breast cancer. Methods A systematic review was conducted between years 1966 to 2006 of all studies designed to assess the effect of decision aids on surgical therapy. MEDLINE, EMBASE, Cumulative Index to Nursing and Allied Health (CINAHL), the Cochrane Network, HAPI databases, and bibliographies were searched. Of the 123 studies screened, 11 studies met criteria. Meta-analyses were performed to assess the pooled relative risk for surgical choice and the pooled mean difference in patient knowledge. Results Results from randomized controlled trials indicated that women who used a decision aid were 25% more likely to choose breast-conserving surgery over mastectomy (risk ratio, 1.25; 95% CI, 1.11 to 1.40). Decision aids significantly increased patient knowledge by 24% (P = .024). The data also suggested that decision aids decreased decisional conflict and increased satisfaction with the decision-making process. Decision aids were well received by surgeons and patients, facilitated patients’ desire for shared decision making, and were feasible to implement into practice. Conclusion Decision aids are important adjuncts for counseling women with early-stage breast cancer. Their use increases the likelihood that women will choose breast-conserving surgery, and enhances patient knowledge of treatment options.
Phase II Study on the Effect of Disease Sites, Age, and Prior Therapy on Response to Iodine-131-Metaiodobenzylguanidine Therapy in Refractory Neuroblastoma
Authors: Matthay Katherine K. , Yanik Gregory , Messina Julia , Quach Alekist , Huberty John , Cheng Su-Chun , Veatch Janet , Goldsby Robert , Brophy Patricia , Kersun Leslie S. , Hawkins Randall A. , Maris John M. 
Published: March 2007

Purpose To evaluate the effect of disease sites and prior therapy on response and toxicity after iodine-131-metaiodobenzylguanidine (131I-MIBG) treatment of patients with resistant neuroblastoma. Patients and Methods One hundred sixty-four patients with progressive, refractory or relapsed high-risk neuroblastoma, age 2 to 30 years, were treated in a limited institution phase II study. Patients with cryopreserved hematopoietic stem cells (n = 148) were treated with 18 mCi/kg of 131I-MIBG. Those without hematopoietic stem cells (n = 16) received 12 mCi/kg. Patients were stratified according to prior myeloablative therapy and whether they had measurable soft tissue involvement or only bone and/or bone marrow disease. Results Hematologic toxicity was common, with 33% of patients receiving autologous hematopoietic stem cell support. Nonhematologic grade 3 or 4 toxicity was rare, with 5% of patients experiencing hepatic, 3.6% pulmonary, 10.9% infectious toxicity, and 9.7% with febrile neutropenia. The overall complete plus partial response rate was 36%. The response rate was significantly higher for patients with disease limited either to bone and bone marrow, or to soft tissue (compared with patients with both) for patients with fewer than three prior treatment regimens and for patients older than 12 years. The event-free survival (EFS) and overall survival (OS) times were significantly longer for patients achieving response, for those older than 12 years and with fewer than three prior treatment regimens. The OS was 49% at 1 year and 29% at 2 years; EFS was 18% at 1 year. Conclusion The high response rate and low nonhematologic toxicity with 131I-MIBG suggest incorporation of this agent into initial multimodal therapy of neuroblastoma.
Methods of Analysis for Imaging and Detecting Ions and Molecules
Authors: Umezawa Yoshio 
Published: March 2007

Abstract
For imaging molecular processes in living cells, we developed novel intracellular fluorescent and bioluminescent indicators for second messengers, protein phosphorylation, protein/protein interactions, and protein localizations that work in single living cells. Key molecules and steps of cellular signaling pathways were visualized in target live cells under fluorescent microscopy using developed fluorescent indicators. A second new approach to molecular imaging is also described. Chemically modified STM tips (molecular tips) were developed for molecular imaging at the interfaces. The molecule-specific imaging is based on an increase in a tunneling current due to the overlap of electronic wave functions induced by the chemical interactions between tip and sample molecules. Chemically selective imaging using STM molecular tips can be described as intermolecular tunneling microscopy.
In Situ Observation of Laser-Induced Convection of Water in High Magnetic Fields Using a Photochromic Reaction
Authors: Tanimoto Yoshifumi , Sueda Kazutaka , Irie Masahiro 
Published: March 2007

Abstract
The effects of vertical magnetic fields on laser-induced convection of water were studied using a photochromic reaction of a water-soluble 1,2-diarylethene (WSD). A thin blue disk of its photoisomer (PI) solution was formed on the bottom surface; it moved upward when the WSD aqueous solution was irradiated using a 355 nm laser from the bottom of the vessel. The lift speeds of the PI solution were about 2.5 (11 T, +1200 T2 m−1), 1.2 (11 T, −1500 T2 m−1), and 1.6 mm min−1 (15 T, −100 T2 m−1). All results are described in terms of the magnetic force acting on the PI solution.
Chemical Speciation of Arsenic Species in Human Blood Serum by Liquid Chromatography Using a Phosphatidylcholine-Coated ODS Column with Detection by ICP-MS
Authors: Hasegawa Takuya , Ishise Jotaro , Fukumoto Yasuharu , Matsuura Hirotaka , Zhu Yanbei , Umemura Tomonari , Haraguchi Hiroki , Yamamoto Kazuhito , Naoe Tomoki 
Published: March 2007

Abstract
Chemical speciation of arsenic species in human blood serum was performed by high-performance liquid chromatography/inductively coupled plasma mass spectrometry (HPLC/ICP-MS) with direct sample injection, where an octadecylsilyl silica (ODS) column coated with phosphatidylcholine (PC) (hereafter known as “PC-coated ODS column”) was used as the separation column. In arsenic species analysis, a citrate buffer solution (pH 4.0) was used as the mobile phase, in which the following reagents were added: sodium 1-dodecanesulfonate (SDS), tetramethylammonium hydroxide (TMAH), which are ion-pair reagents to separate inorganic and organic arsenic species, and 3-[(3-cholamidopropyl)dimethylammonio]-1-propane sulfonate (CHAPS), which is a protein-solubilizing agent to prevent adsorption of proteins on the column. As a result of optimization, five representative arsenic species spiked in human blood serum reference material could be separated from each other within 5 min on the PC-coated ODS column by elution with a 5 mM citrate buffer (pH 4.0) containing 5 mM SDS, 5 mM THAH, and 0.2 mM CHAPS. The detection limits obtained by ICP-MS were 3.1, 2.7, 4.5, 2.5, and 2.5 ng of As g−1 for arsenate (iAsV), arsenite (iAsIII), monomethylarsonic acid (MMA), dimethylarsenic acid (DMA), and arsenobetaine (AB), respectively, when the injection volume was 20 μL. The present separation system was also applied to speciation analysis of arsenic species in human blood serum collected from a leukemia patient after therapeutic treatment with arsenic.
Characteristics of Mononuclear Ruthenium–Oxo Complexes Adjusted by Axial Ligand for the Catalysis of Oxygen-Transfer Reactions
Authors: Okumura Takeshi , Morishima Yuji , Shiozaki Hiroyoshi , Yagyu Takeyoshi , Funahashi Yasuhiro , Ozawa Tomohiro , Jitsukawa Koichiro , Masuda Hideki 
Published: March 2007

Abstract
Ruthenium(II) complexes, [Ru(babp)(dmso)L], consisting of tetradentate square-planar ligand (babp = 6,6′-bis(benzoylamino)-2,2′-bipyridinato) and two monodentate axial ones, DMSO and L (L = dmso or heterocycles), were synthesized and structurally characterized using UV–vis, NMR, ESI-MS, and IR spectroscopies and X-ray crystallography. These complexes showed catalytic activity toward the oxygen-atom-transfer reactions, such as epoxidation, allylic oxidation, cleavage reaction of olefins, and sulfoxidation of thioethers, in the presence of oxidant, PhIO. The relationship between the coordination structure and the catalytic activities of [Ru(babp)(dmso)L] was investigated. The active species for the reaction was assigned to be a high valent RuV=O or RuVI=O species. The oxo ligand was generated from the ligand-exchange reaction involving the dmso attached to [Ru(babp)(dmso)L]. Some complexes having a labile ligand at an axial position gave a RuVI=O species as an active intermediate, and others having moderate coordinating one gave a RuV=O one. The oxidation activities of these complexes were affected by the axial ligand, L, through the trans-influence.