bluuebunny/crossref_metadata_2025_split huggingface dataset:
Performance of a commercially available Generative Pre-trained Transformer (GPT) in describing radiolucent lesions in panoramic radiographs and establishing differential diagnoses
Authors: Silva Thaísa Pinheiro , Andrade-Bortoletto Maria Fernanda Silva , Ocampo Thaís Santos Cerqueira , Alencar-Palha Caio , Bornstein Michael M. , Oliveira-Santos Christiano , Oliveira Matheus L. 
Published: March 2024

Abstract
Objectives
To evaluate the performance of a commercially available Generative Pre-trained Transformer (GPT) in describing and establishing differential diagnoses for radiolucent lesions in panoramic radiographs.

Materials and methods
Twenty-eight panoramic radiographs, each containing a single radiolucent lesion, were evaluated in consensus by three examiners and a commercially available ChatGPT-3.5 model. They provided descriptions regarding internal structure (radiodensity, loculation), periphery (margin type, cortication), shape, location (bone, side, region, teeth/structures), and effects on adjacent structures (effect, adjacent structure). Diagnostic impressions related to origin, behavior, and nature were also provided. The GPT program was additionally prompted to provide differential diagnoses. Keywords used by the GPT program were compared to those used by the examiners and scored as 0 (incorrect), 0.5 (partially correct), or 1 (correct). Mean score values and standard deviation were calculated for each description. Performance in establishing differential diagnoses was assessed using Rank-1, -2, and − 3.

Results
Descriptions of margination, affected bone, and origin received the highest scores: 0.93, 0.93, and 0.87, respectively. Shape, region, teeth/structures, effect, affected region, and nature received considerably lower scores ranging from 0.22 to 0.50. Rank-1, -2, and − 3 demonstrated accuracy in 25%, 57.14%, and 67.85% of cases, respectively.

Conclusion
The performance of the GPT program in describing and providing differential diagnoses for radiolucent lesions in panoramic radiographs is variable and at this stage limited in its use for clinical application.

Clinical relevance
Understanding the potential role of GPT systems as an auxiliary tool in image interpretation is imperative to validate their clinical applicability.
Real-world evaluation of persistence, effectiveness and usage patterns of tofacitinib in treatment of psoriatic arthritis in Australia
Authors: Littlejohn Geoffrey , Leadbetter Joanna , Butcher Belinda E. , Feletar Marie , O’Sullivan Catherine , Smith Tegan , Witcombe David , Ng Ho Yin , Youssef Peter 
Published: March 2024

Abstract
Objectives
To describe treatment patterns and persistence of tofacitinib, interleukin 17 inhibitors (IL-17Ai) and tumour necrosis factor inhibitors (TNFi), in patients with psoriatic arthritis (PsA).

Methods
Data from adult patients with PsA and who had received at least one prescription of tofacitinib, IL-17Ai or TNFi between May 2019 and September 2021 were sourced from the Australian OPAL dataset. Persistence, analysed via Kaplan–Meier methods, and propensity score matching between tofacitinib and bDMARD (IL-17Ai and TNFi) groups were conducted.

Results
Of 16,692 patients with PsA, 1486 (n = 406 tofacitinib, n = 416 IL-17Ai and n = 664 TNFi) were included. More females were in the tofacitinib group (75.4%) than in the IL-17Ai (61.1%) and TNFi (64.8%) groups. Overall, 19.2% of tofacitinib patients were first line, compared with 41.8% of IL-17Ai and 62.8% of TNFi patients. In the overall population, the median persistence was 16.5 months (95% CI 13.8 to 19.5 months), 17.7 months (95% CI 15.8 to 19.6 months) and 17.2 months (95% CI 14.9 to 20.5 months) in the tofacitinib, IL-17Ai and TNFi groups, respectively. Persistence was similar in the tofacitinib/IL-17Ai matched population; however, in the tofacitinib/TNFi matched population, persistence was longer in the tofacitinib group (18.7 months, 95% CI 15.6 to 21.4 months) compared with the TNFi group (12.2 months, 95% CI 19.9 to 14.9 months).

Conclusions
In this Australian real-world dataset, tofacitinib was more frequently used in later lines and among a slightly higher proportion of female patients than IL-17Ai or TNFi. Overall, treatment persistence was similar for tofacitinib, IL-17Ai and TNFi, but tofacitinib exhibited longer persistence than TNFi in a matched population.

Key Points• This is the first, large real-world study from Australia investigating the demographics, treatment patterns and comparative treatment persistence of patients with psoriatic arthritis (PsA) treated with tofacitinib and biologic disease-modifying drugs (bDMARDs).• The study suggests that tofacitinib is an effective intervention in PsA with at least comparable persistence to bDMARDs: tumour necrosis factor inhibitors (TNFi) and interleukin-17 A inhibitors (IL-17Ai).
Does selective digestive decontamination (SDD) increase antibiotic resistance? Long-term comparison of two intensive care units (with and without SDD) of the same tertiary hospital
Authors: Rodríguez-Gascón Alicia , Lloréns-Villar Yanire , Solinís María Ángeles , Barrasa Helena , Canut-Blasco Andrés 
Published: March 2024

Abstract
Purpose
The aim of this study was to to compare the antimicrobial resistance rate and its relationship with the antibiotic consumption in two separate Intensive Care Units (ICUs) of the same hospital, one with and other without selective decontamination of the digestive tract (SDD).

Methods
We performed a retrospective study in the two ICUs of the Araba University Hospital. Trauma and neurosurgical patients are admitted to the SDD-ICU, and general digestive surgery patients go to the no SDD-ICU. From 2014 to 2018 we analyzed the number of isolates, and the bacterial resistance trends of 47 antimicrobial-microorganism combinations. Additionally, antimicrobial consumption was estimated in both ICUs. Resistance rates were also compared with those reported in ENVIN-HELICS Spanish national registry.

Results
In the ICU with SDD protocol, there was a significant decrease in the resistance of E. coli to amoxicillin/clavulanic acid and in the resistance of E. faecalis to high concentration of gentamycin and high concentration of streptomycin. A significant increase of resistance of Staphylococcus coagulasa negative (CoNS) to linezolid in the no SDD-ICU was also detected. Overall, the level of resistance in the SDD-ICU was lower or of the same order than in the ICU without SDD and that reported in the Spanish national registry.

Conclusions
SDD had neither a clinically relevant impact on emergence and spread of resistance, nor in the overall systemic antimicrobial use. The patient type rather than the SDD protocol showed to condition the ecology and therefore, the resistance rate in the ICUs.
A lexicographic optimisation approach to promote more recent features on longitudinal decision-tree-based classifiers: applications to the English Longitudinal Study of Ageing
Authors: Ribeiro Caio , Freitas Alex A. 
Published: March 2024

AbstractSupervised machine learning algorithms rarely cope directly with the temporal information inherent to longitudinal datasets, which have multiple measurements of the same feature across several time points and are often generated by large health studies. In this paper we report on experiments which adapt the feature-selection function of decision tree-based classifiers to consider the temporal information in longitudinal datasets, using a lexicographic optimisation approach. This approach gives higher priority to the usual objective of maximising the information gain ratio, and it favours the selection of features more recently measured as a lower priority objective. Hence, when selecting between features with equivalent information gain ratio, priority is given to more recent measurements of biomedical features in our datasets. To evaluate the proposed approach, we performed experiments with 20 longitudinal datasets created from a human ageing study. The results of these experiments show that, in addition to an improvement in predictive accuracy for random forests, the changed feature-selection function promotes models based on more recent information that is more directly related to the subject’s current biomedical situation and, thus, intuitively more interpretable and actionable.
Dietary feed nanozeolite, Pediococcus, and medium-chain fatty acid enhanced growth performance and transcription of growth-related gene of Nile tilapia (Oreochromis niloticus)
Authors: Elshafy Manar Bahaa Abd , El-Monem Asmaa Ibrahim Mohamed Abd , Khattab Ibrahim M. , Abdo Safaa E. , Fadl Sabreen E. , Khadiga Galal Abou 
Published: March 2024

AbstractThe current trial was designed to evaluate the positive impacts of different feed additives singly or in combination on the growth performance, nutritional parameters, intestinal histology, and gene expression of some growth and fat metabolism-related genes in the liver tissue of Nile tilapia. The experimented fish were allocated into eight groups in a glass aquarium (10 fish/aquarium in triplicate) with Pediococcus acidilactici, nanozeolites, and/or medium-chain fatty acid additives. The studied treatments were control (T0), nanozeolite (T1), Pediococcus (T2), medium-chain fatty acid (T3), nanozeolite + Pediococcus (T4), nanozeolite + medium-chain fatty acid (T5), Pediococcus + medium-chain fatty acid (T6), and nanozeolite + Pediococcus + medium-chain fatty acid (T7). The results of the growth and nutritional parameters (i.e., final body weight, total weight gain, feed intake, specific growth rate, feed conversion ratio, and protein efficiency ratio) of tilapia-fed diets supplemented with Pediococcus, nanozeolites, and medium-chain fatty acids improved, but the combination of these additives was significantly more effective. Moreover, expression of growth hormone receptor 1 gene was upregulated (P ≤ 0.05) in T7 fish when compared with T0, other groups showing intermediate values. Expression of insulin-like growth factor-1 was upregulated (P ≤ 0.05) in T5, T6, and T7 fish when compared with the other groups. The expression of the fatty acid-binding protein was higher in T6 and T7 fish (P ≤ 0.05) when compared with T0, T1, and T3 fish. In conclusion, combined additives had significant effects on improving growth and regulating growth-related genes.
Rivers and tidal flats as sources of dissolved organic matter and trace metals in the German Bight (North Sea)
Authors: Speidel Linn G. , Carvalho da Silva Roger , Beck Melanie , Dellwig Olaf , Wollschläger Jochen , Dittmar Thorsten , Seidel Michael 
Published: March 2024

AbstractThe German Bight in the southern North Sea receives nutrients, dissolved organic matter (DOM), and trace metals from rivers, porewater reflux, and porewater outwelling. We studied the marine, riverine, and porewater sources analyzing molecular transformations of solid-phase extracted (SPE) DOM in the German Bight. We applied a combination of ultrahigh-resolution mass spectrometry (FT-ICR-MS) with quantitative data of dissolved organic sulfur (DOS), dissolved black carbon (DBC), dissolved trace metals (Ba, Co, Gd, Mo, Mn, W), and nutrients (nitrite, nitrate, phosphate, silicate). While aromatic DOM and DBC mainly originated from the rivers, nitrogen-containing, more saturated DOM was enriched offshore suggesting greater contributions of marine (algal) sources. Except for dissolved Mo, rivers were the primary source of trace metals and nutrients. However, tidal flats contributed to dissolved nutrient (e.g., dissolved phosphate), trace metal and DOS inventories of the southern North Sea. The input of DOS from intertidal flats was identified by the molecular index derived from sulfidic porewaters (ISuP), non-conservative behavior of elemental sulfur-to-carbon ratio and sulfur content of molecular formulae (from FT-ICR-MS). Dissolved Mn and Si were removed in the German Bight, likely due to precipitation as Mn(hydr)oxides and biological uptake, respectively. Preliminary estimates suggest that DOS from porewater outwelling is approximately four times higher than DOS discharged by the three main rivers in the region. Our study therefore highlights the need to consider porewater discharge in addition to riverine sources to comprehensively assess elemental budgets within the complex interplay and transformations of DOM, nutrients, and trace metals in coastal ecosystems.
Labile organic matter promotes nitrogen retention in natural and constructed gulf coast marshes
Authors: Starr S. F. , Mortazavi B. , Tatariw C. , Kuehn K. A. , Cherry J. A. , Ledford T. , Smyth E. , Wood A. Griffin , Sebren S. E. 
Published: March 2024

AbstractCoastal marshes mitigate allochthonous nitrogen (N) inputs to adjacent marine habitat; however, their extent is declining rapidly. As a result, marsh restoration and construction have become a major foci of wetland management. Constructed marshes can quickly reach similar plant biomass to natural marshes, but biogeochemical functions like N removal and retention can take decades to reach functional equivalency, often due to lags in organic matter (OM) pools development in newly constructed marshes. We compared denitrification and dissimilatory nitrate reduction to ammonium (DNRA) rates in a 32 year-old constructed marsh and adjacent reference marsh in the Northern Gulf of Mexico. Marsh sediments packed into 3 mm “thin discs” were subjected to three OM quality treatments (no OM addition, labile OM, or recalcitrant OM) and two N treatments (ambient nitrate or elevated nitrate) during a 13 day incubation. We found that OM addition, rather than marsh type or nitrate treatment, was the most important driver of nitrate reduction, increasing both denitrification and DNRA and promoting DNRA over denitrification in both marshes. Fungal and bacterial biomass were higher in the natural marsh across treatments, but recalcitrant OM increased fungal biomass in the constructed marsh, suggesting OM-limitation of fungal growth. We found that constructed marshes are capable of similar denitrification and DNRA as natural marshes after 30 years, and that labile OM addition promotes N retention in both natural and constructed marshes.Graphical AbstractConceptual figure highlighting the findings of this experiment. Under control treatment with no C addition (bottom panel), constructed and natural marshes have similar rates of both DNRA and denitrification. The natural marsh has higher fungal and bacterial biomass, while fungal biomass is not detectable in the constructed marsh. Under labile OM additions (upper left panel), rates of both DNRA and denitrification are increased and DNRA becomes favored over denitrification in both marshes. Recalcitrant OM additions (upper right) increase denitrification, but do not affect DNRA or % denitrification. The addition of recalcitrant OM also increases the detectability of fungal biomass in the constructed marsh.
Citizenship in the Elementary Classroom Through the Lens of Peer Relations
Authors: Krijnen Minke A. , Wansink Bjorn G. J. , van den Berg Yvonne H. M. , van Tartwijk Jan , Mainhard Tim 
Published: March 2024

AbstractWe explored the potential of using a peer relations approach for researching children’s citizenship in elementary classrooms. Children express or enact citizenship through their behavior toward classmates and the relationships they engage in (i.e., lived citizenship). These behaviors and relationships can be more or less in line with goals for citizenship education. We propose that, through peer relations methodology, these behaviors and relationships can be assessed systematically. In addition, some of the widely researched behaviors and relationships in peer relations research already closely align with goals for citizenship education. With this theoretical and methodological argument, we consider recent publications on classroom behaviors (i.e., prosocial behavior and aggression) and relationships (i.e., positive and negative affect) and their meaning for exemplary goals for citizenship education (i.e., solidarity, peace, and social cohesion). We show how individual children and classroom peer groups differ in these regards and thus in their citizenship and how these differences can be stratified by gender, ethnic background, and socioeconomic status. Specific attention is paid to the role of teachers, as organizers of the social structures in their classrooms and as educators who can promote citizenship. Finally, we propose new ways for using peer reports to study citizenship in elementary classrooms more directly and to discover potential avenues for teachers to foster citizenship through peer relations.
Practice Recommendations or Not? The LoGeT Model as Empirical Approach to Generate Localized, Generalized, and Transferable Evidence
Authors: Lachner Andreas , Sibley Leonie , Wagner Salome 
Published: March 2024

AbstractIn educational research, there is the general trade-off that empirical evidence should be generalizable to be applicable across contexts; at the same time, empirical evidence should be as specific as possible to be localizable in subject-specific educational interventions to successfully transfer the empirical evidence to educational practice. This trade-off is further increased by the fact that the diverse instructional contexts, such as school or student characteristics constrain the applicability of empirical evidence. Several approaches have been proposed to address this issue, however, emphasized the different problems (i.e., localization, generalization, transferability) rather in an isolated manner. To this end, in this article, we introduce a synergistic approach, the LoGeT (localize, generalize, transfer) model, which systematically integrates co-design (localization strategies) and ManyClasses principles (generalization strategies) with co-constructive transfer activities, to generate empirical evidence that may be applicable in educational practice. To illustrate the LoGeT model, we present three long-term projects, covering different granularities and durations of educational interventions across different fields of education (teacher education, adaptive teaching, non-interactive teaching) that successfully applied the LoGeT approach. Finally, we outline further directions for future iterations of the LoGeT model. We hope that the LoGeT approach may be a stimulus to guide researchers as well as practitioners alike to design generalizable and evidence-based educational interventions that are rooted in localized instructional contexts.
How many random observations are needed for good phase coverage of a periodic source?
Authors: Koen Chris 
Published: March 2024

AbstractThe specific problem considered is the number of radial velocity measurements required to obtain good estimates of physical parameters of binary star. It is assumed that observations are made at random binary phases. The loss of information due to poor phase coverage is explored, and a suggested limit on the largest acceptable gap introduced. The statistical distribution of maximum gap lengths can then be used to specify the minimum number of velocity measurements to obtain good phase coverage with a specified confidence limit. The effects of non-zero orbital eccentricity are discussed, as are the ramifications of having multiple binary targets. The theory is also applicable to the characterisation of the radial velocity curves induced by exoplanets on their host stars, provided that the periods and eccentricities are known (from e.g. transit observations).
Farm adaptation to stricter nutrient management legislation and the implications for future livestock production: a review
Authors: Méité René , Artner-Nehls Astrid , Uthes Sandra 
Published: March 2024

AbstractStricter nutrient surplus and lower emission targets are placing adaptation pressure on livestock farms in European countries, while the public debate on how farms should react upon this pressure is controversial. In this paper, we performed an integrative literature review on different farm adaptation options, including (i) structural adaptation, (ii) technological adaptation, (iii) manure redistribution, and (iv) farm system conversion. Our analysis showed that stricter environmental legislation, together with complementary supply- and demand-related drivers, induced various farm responses. These ranged from easy to implement solutions (e.g. moderate livestock destocking to the legal levels combined with the adoption of emission abatement technologies) to novel niche concepts (e.g. animal husbandry without slaughtering). Possible reactions of farmers differed in their complexity and feasibility across different farm types and involved different trade-offs between environmental and socioeconomic interests. Future livestock production is expected to be diverse with different coexisting models that combine features of different adaptation options. The private and public sustainability of these models depends on their ability to simultaneously address multiple emerging challenges (e.g. emission reduction, animal welfare, biosecurity, and circularity). Current technological solutions often focus on a single objective (e.g. emission reduction). Integrated and multifunctional solutions (e.g. low-emission animal welfare barns compatible with biosecurity measures) are not yet sufficiently adopted, which calls for a rethinking and shifting in priorities in legislation and funding schemes.
Efficacy and safety of high-power short-duration ablation for atrial fibrillation: a systematic review and meta-analysis of randomized controlled trials
Authors: Amin Ahmed Mazen , Ghaly Ramy , Ibrahim Ahmed A. , Ali Mohamed Ahmed , Almaadawy Omar , Elzahaby Amr , Abuelazm Mohamed , Abdelazeem Basel , Munir Muhammad Bilal 
Published: March 2024

Abstract
Background
High-power short-duration (HPSD) ablation has emerged as an alternative to conventional standard-power long-duration (SPLD) ablation. We aim to assess the efficacy and safety of HPSD versus SPLD for atrial fibrillation (AF) ablation.

Methods
A systematic review and meta-analysis of randomized controlled trials (RCTs) retrieved from PubMed, WOS, SCOPUS, EMBASE, and CENTRAL were performed through August 2023. We used RevMan V. 5.4 to pool dichotomous data using risk ratio (RR) and continuous data using mean difference (MD) with a 95% confidence interval (CI). PROSPERO ID: CRD42023471797.

Results
We included six RCTs with a total of 694 patients. HPSD was significantly associated with a decreased total procedure time (MD: -22.88 with 95% CI [-36.13, -9.63], P = 0.0007), pulmonary vein isolation (PVI) time (MD: -19.73 with 95% CI [-23.93, -15.53], P < 0.00001), radiofrequency time (MD: -10.53 with 95% CI [-12.87, -8.19], P < 0.00001). However, there was no significant difference between HPSD and SPLD ablation with respect to the fluoroscopy time (MD: -0.69 with 95% CI [-2.00, 0.62], P = 0.30), the incidence of esophageal lesions (RR: 1.15 with 95% CI [0.43, 3.07], P = 0.77), and the incidence of first pass isolation (RR: 0.98 with 95% CI [0.88, 1.08], P = 0.65).

Conclusion
HPSD ablation was significantly associated with decreased total procedure time, PVI time, and radiofrequency time compared with SPLD ablation. On the contrary, SPLD ablation was significantly associated with low maximum temperature.

Graphical Abstract