bluuebunny/crossref_metadata_2025_split huggingface dataset:
Особливості організації роботи закладу дошкільної освіти з розвитку педагогічної культури батьків дітей раннього віку
Authors: Швець Тетяна 
Published: April 2024

У статті розглянуто особливості організації роботи закладом дошкільної освіти з розвитку педагогічної культури батьків дітей раннього віку. Автор обґрунтовує важливість формування зазначеного феномену у закладі дошкільної освіти, аналізує наукові доробки вчених щодо досліджуваного поняття. Схарактеризовано «педагогічну культуру» як компонент загальної культури особистості, що пов’язана з досвідом результативної передачі культурної спадщини молодому поколінню за допомогою освітнього процесу. Педагогічна культура є компонентом загальної культури особистості, що стосується досвіду ефективної передачі культурної спадщини старшими поколіннями молодшим за допомогою освітнього процесу. Зазначено, що батьки є активними суб’єктами освітнього процесу, які хаотично здійснюють передачу молодшому поколінню культурного досвіду.Вказано, що у багатьох закладах дошкільної освіти відбувається активний пошук та реалізація таких форм співпраці із сім’ями дітей раннього віку, які б сприяли досягненню якісного рівня комунікації (анкетування, батьківські збори, консультування, дні відчинених дверей тощо). В організації комунікації з батьками виокремлено використання колективних, індивідуальних та наочно-­інформаційних форм взаємодії.Також пріоритетною формою розвитку педагогічної культури батьків дітей раннього віку визначено фронтальну форму організації, практична реалізація якої здійснюється за допомогою семінарів-­практикумів, тематичних виставок та конференцій для батьків. Також використовують групову (аналіз педагогічних виховних ситуацій, тематичні консультації) й індивідуальну форми.Для дистанційного формату взаємодії актуальними є індивідуальні консультації за допомогою освітніх платформ Zoom, Google Мeet, інтерактивна групова та фронтальна робота за допомогою ресурсів Mentimetr, Trello, Padlet тощо.Узагальнено проаналізовані дослідження та констатовано, що сім’я – це природнє середовище базової соціалізації малюка, джерело її психологічної, емоційної та матеріальної підтримки, засіб збереження і передачі культурних цінностей та традицій від покоління до покоління. Вона є осередком первинного гармонійного розвитку дітей раннього віку, але стан розвитку малюків у таких умовах є незадовільним і вимагає надання професійного педагогічного супроводу батькам, які виховують дітей раннього віку.
Система психологічної та педагогічної реабілітації дітей у прифронтових громадах
Authors: Кияновський Артем , Гуренок Галина 
Published: April 2024

У статті описано систему психологічної та педагогічної реабілітації дітей у прифронтовій громаді на прикладі роботи комунального закладу «Навчально-­виховний комплекс «Школа гуманітарної праці» Херсонської обласної ради (м. Херсон). У корпусі початкової школи облаштовано безпечне укриття, яке відповідає всім нормам та максимально комфортне для перебування дітей, педагогів і батьків, та створено Центр психологічної допомоги дітям. Актуальність такого Центру безперечна, оскільки місто, у якому проживає понад 8 тисяч дітей, щодня обстрілюється з грудня 2022 року. Запит батьків зумовив організацію у 2023/2024 навчальному році комплексних занять у малих групах, де з дітьми працюють не тільки практичний психолог, логопед, дефектолог, а й учителі початкової школи, англійської мови. Крім того, розпочала роботу Освітня лабораторія психологічної підтримки учасників освітнього процесу.Дії адміністрації «Школи гуманітарної праці» щодо реабілітації дітей ґрунтуються на результатах анкетувань батьків і дітей, частково поданих у статті.Відповідно до тематики наукової розвідки розкрито особливості реакції дітей на труднощі та стресові ситуації порівняно з реакціями дорослих, визначено важливість психологічної роботи не лише з дитиною, а й із її батьками. Надано перелік методик, використовуваних психологами в індивідуальній роботі з родинами й педагогами; розклад індивідуальних консультацій у Центрі для учнів 1-го, 2-го, 4-го, 5-го та 6-го класів.Оскільки описана система психологічної та педагогічної реабілітації показує позитивну динаміку, об’єктивно спостерігаються обнадійливі зміни, основний висновок полягає в необхідності комплексного підходу до реабілітації дітей у прифронтових громадах.
Hubungan Sosiodemografi Orang Tua dengan Sikap Remaja Tentang Kesehatan Reproduksi Remaja
Authors: Solehati Tetti , Kosasih Cecep Eli , Rahmat Agus 
Published: April 2024

Sosiodemografi orang tua memiliki peranan yang cukup besar dalam membentuk sikap anak remaja,salah satunya sikap anak remaja tentang kesehatan reproduksi remaja (KRR). Tujuan penelitian untuk mengetahui hubungan sosiodemografi orang tua terhad sikap remaja tentang KRR. Rancangan penelitian cross sectional. Pengumpulan data dilakukan melalui pengisian instrumen quisioner. Data dianalisa menggunakan Chi Squere. Penelitian dilakukan tahun 2017 di SMPN dan SMAN wilayah Kabupaten Bandung. Populasi penelitian ini adalah seluruh siswa SMP dan SMA yang digunakan sebagai lokasi penelitian sejumlah 12.000. Sample berjumlah 668 siswa menggunakan rumus Slovin. Tehnik pengambilan sample dengan stratified random sampling. Hasil penelitian diperoleh bahwa Variabel sikap berhubungan dengan pekerjaan orang tua (p=0,000), pendidikan orang tua (p=0,000), dan pendapatan keluarga (p=0,000). Kesimpulan: sosiodemografi orang tua memiliki hubungan dengan sikap pada anak remaja. Berdasarkan hasil penelitian dan pembahasan, disarankan agar orang tua dapat menjalankan perannya sebagai pengendali sikap anak remaja dalam mendukung perilaku anak remaja terhadap kesehatan reproduksi remaja.
Perkawinan Beda Agama Perspektif HAM dan Hukum Islam: Studi Fatwa Majelis Ulama’ Indonesia No 4/2005
Authors: Rozikin Muhammad Khoirul , Quthni Abu Yazid Adnan , Nugrhoho Irzak Yuliardy 
Published: April 2024

This research is motivated by the increasing trend of interfaith marriages among the population, driven by the inseparable love between partners despite their differing religious beliefs. Human rights or the absence of state law are often invoked as legal grounds to legitimize such marriages. Specifically, this study focuses on the Indonesian Ulema Council (MUI) Fatwa No. 4/2005, which rejects interfaith marriages and analyzes the associated risks. The research employs a library research method with a qualitative approach, concentrating on document analysis. Primary data sources include the Republic of Indonesia Law No. 1 of 1974 regarding marriage, MUI fatwas on interfaith marriage, Quranic verses, Hadiths, and Islamic law (maqasid al-shariah). Additionally, secondary data from relevant books or journals are utilized. The findings indicate that the legal validity of a marriage is determined solely by religious norms, not state law. Therefore, the government's authority is limited to regulating the registration of marriages valid according to religious norms, not legalizing marriage status. The prohibition of interfaith marriages is attributed to the increased risks involved in forming a family.
Keywords: Interfaith Marriage, Islamic Law, MUI Fatwa
Zebrafish cobll1a regulates lipid homeostasis via the RA signaling pathway
Authors: Zeng Ting , Lv Jinrui , Liang Jiaxin , Xie Binling , Liu Ling , Tan Yuanyuan , Zhu Junwei , Jiang Jifan , Xie Huaping 
Published: April 2024

Background:The COBLL1 gene has been implicated in human central obesity, fasting insulin levels, type 2 diabetes, and blood lipid profiles. However, its molecular mechanisms remain largely unexplored.Methods:In this study, we established cobll1a mutant lines using the CRISPR/Cas9-mediated gene knockout technique. To further dissect the molecular underpinnings of cobll1a during early development, transcriptome sequencing and bioinformatics analysis was employed.Results:Our study showed that compared to the control, cobll1a−/− zebrafish embryos exhibited impaired development of digestive organs, including the liver, intestine, and pancreas, at 4 days post-fertilization (dpf). Transcriptome sequencing and bioinformatics analysis results showed that in cobll1a knockout group, the expression level of genes in the Retinoic Acid (RA) signaling pathway was affected, and the expression level of lipid metabolism-related genes (fasn, scd, elovl2, elovl6, dgat1a, srebf1 and srebf2) were significantly changed (p &lt; 0.01), leading to increased lipid synthesis and decreased lipid catabolism. The expression level of apolipoprotein genes (apoa1a, apoa1b, apoa2, apoa4a, apoa4b, and apoea) genes were downregulated.Conclusion:Our study suggest that the loss of cobll1a resulted in disrupted RA metabolism, reduced lipoprotein expression, and abnormal lipid transport, therefore contributing to lipid accumulation and deleterious effects on early liver development.
First-line surgery versus first-line assisted reproductive technology for women with deep infiltrating endometriosis: a systematic review and meta-analysis
Authors: Liang Ying , Liu Min , Zhang Jianmei , Mao Zenghui 
Published: April 2024

BackgroundThe efficiency of different first-line treatments, such as first-line surgery and assisted reproductive technology (ART), in women with deep infiltrating endometriosis (DIE) is still unclear due to a lack of direct comparative trials. This systematic review and meta-analysis aim to elucidate and compare the efficacies of first-line treatments in patients with DIE, with an emphasis on fertility outcomes.MethodsAn exhaustive search of PubMed Central, SCOPUS, EMBASE, MEDLINE, Cochrane trial registry, Google Scholar, and Clinicaltrials.gov databases was done to identify studies directly comparing first-line surgery and assisted reproductive technology (ART) for DIE, and reporting fertility-related outcomes. Pooled estimates for each of the binary outcomes were reported as odds ratios (ORs) with 95% confidence intervals (CIs). The results were pooled using a random-effects model with the Mantel-Haenszel technique.ResultsOur results show that pregnancy rate per patient (OR, 1.47; 95% CI, 0.59 to 3.63), pregnancy rate per cycle (OR, 1.16; 95% CI, 0.45 to 2.99), and live births per patient (OR, 1.66; 95% CI, 0.56 to 4.91) were comparable in DIE patients, treated with surgery or ART as a first line of treatment. When both complete and incomplete surgical DIE excision procedures were taken into account, surgery was associated with a significant enhancement in the pregnancy rate per patient (OR, 1.63; 95% CI, 1.11 to 2.40).ConclusionThe available evidence suggests that both first-line surgery and ART can be effective DIE treatments with similar fertility outcomes. However, further analysis reveals that excluding studies involving endometriomas significantly alters the understanding of treatment efficacy between surgery and ART for DIE-associated infertility.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=426061, identifier CRD42023426061.
Positive association between blood ethylene oxide levels and metabolic syndrome: NHANES 2013-2020
Authors: Zhou Chunqi , Wang Senlin , Ju Lingling , Zhang Ruimin , Yang Yunning , Liu Yanjun 
Published: April 2024

PurposeThe exposure of Ethylene oxide (EO) is linked to systemic inflammatory response and various cardiovascular risk factors. Hemoglobin’s binding to ethylene oxide (HbEO) was used to measure serum EO level. This research aims to explore the association between metabolic syndrome (MetS) and HbEO, and between HbEO and components of metabolic syndrome.MethodThis research included 1842 participants from 2013 to 2020 in National Health and Nutrition Examination Survey (NHANES) database. Weighted logistic regression models were used to analyze the relationship between HbEO and metabolic syndrome risk, using odds ratio (OR) and 95% confidence interval (CI). The restricted cubic spline plot explores whether there is a dose-response relationship between HbEO and MetS risk. Subgroup analysis was performed to analyze study heterogeneity.ResultsSignificant differences were found in gender, educational level, marital status, diabetes status and hypertension among different groups (P &lt; 0.001, P = 0.007, P = 0.003, P &lt; 0.001, P &lt; 0.001, respectively). The serum HbEO level exhibited positive correlation with metabolic syndrome risk in Q2 level (OR=1.64, 1.04~2.48), Q3 level (OR=1.99, 1.29~3.08), and Q4 level (OR=2.89, 1.92~4.34). The dose-response association suggested a possible linear association between serum HbEO and metabolic syndrome risk (P-overall=0.0359, P-non-linear=0.179). L-shaped association was found between HbEO and the risk of MetS in female population, obese population and mid-age and elder population (P-overall&lt;0.001, P-non-linear=0.0024; P-overall=0.0107, P-non-linear=0.0055 P-overall&lt;0.001 P-non-linear=0.0157).ConclusionThis study indicates a linear correlation between MetS and HbEO, with MetS risk escalating as HbEO levels increase. The prevalence of MetS varies depending on BMI, age and gender, and these factors can also influence MetS prevalence when exposed to EO.
Single-cell and bulk RNAseq unveils the immune infiltration landscape and targeted therapeutic biomarkers of psoriasis
Authors: Deng Wenhui , Yan Yijiao , Shi Chengzhi , Sui Daoshun 
Published: April 2024

Background:Psoriasis represents a multifaceted and debilitating immune-mediated systemic ailment afflicting millions globally. Despite the continuous discovery of biomarkers associated with psoriasis, identifying lysosomal biomarkers, pivotal as cellular metabolic hubs, remains elusive.Methods:We employed a combination of differential expression analysis and weighted gene co-expression network analysis (WGCNA) to initially identify lysosomal genes. Subsequently, to mitigate overfitting and eliminate collinear genes, we applied 12 machine learning algorithms to screen robust lysosomal genes. These genes underwent further refinement through random forest (RF) and Lasso algorithms to ascertain the final hub lysosomal genes. To assess their predictive efficacy, we conducted receiver operating characteristic (ROC) analysis and verified the expression of diagnostic biomarkers at both bulk and single-cell levels. Furthermore, we utilized single-sample gene set enrichment analysis (ssGSEA), CIBERSORT, and Pearson’s correlation analysis to elucidate the association between immune phenotypes and hub lysosomal genes in psoriatic samples. Finally, employing the Cellchat algorithm, we explored potential mechanisms underlying the participation of these hub lysosomal genes in cell-cell communication.Results:Functional enrichment analyses revealed a close association between psoriasis and lysosomal functions. Subsequent intersection analysis identified 19 key lysosomal genes, derived from DEGs, phenotypic genes of WGCNA, and lysosomal gene sets. Following the exclusion of collinear genes, we identified 11 robust genes, further refined through RF and Lasso, yielding 3 hub lysosomal genes (S100A7, SERPINB13, and PLBD1) closely linked to disease occurrence, with high predictive capability for disease diagnosis. Concurrently, we validated their relative expression in separate bulk datasets and single-cell datasets. A nomogram based on these hub genes may offer clinical advantages for patients. Notably, these three hub genes facilitated patient classification into two subtypes, namely metabolic-immune subtype 1 and signaling subtype 2. CMap analysis suggested butein and arachidonic fasudil as preferred treatment agents for subtype 1 and subtype 2, respectively. Finally, through Cellchat and correlation analysis, we identified PRSS3-F2R as potentially promoting the expression of hub genes in the psoriasis group, thereby enhancing keratinocyte-fibroblast interaction, ultimately driving psoriasis occurrence and progression.Conclusion:Our study identifies S100A7, SERPINB13, and PLBD1 as potential diagnostic biomarkers, offering promising prospects for more precisely tailored psoriatic immunotherapy designs.
Impact of sexual and reproductive health interventions among young people in sub-Saharan Africa: a scoping review
Authors: Chipako Isaac , Singhal Saurabh , Hollingsworth Bruce 
Published: April 2024

ObjectivesThe aim of this scoping review was to identify and provide an overview of the impact of sexual and reproductive health (SRH) interventions on reproductive health outcomes among young people in sub-Saharan Africa.MethodsSearches were carried out in five data bases. The databases were searched using variations and combinations of the following keywords: contraception, family planning, birth control, young people and adolescents. The Cochrane risk-of-bias 2 and Risk of Bias in Non-Randomized Studies-of-Interventions tools were used to assess risk of bias for articles included.ResultsCommunity-based programs, mHealth, SRH education, counselling, community health workers, youth friendly health services, economic support and mass media interventions generally had a positive effect on childbirth spacing, modern contraceptive knowledge, modern contraceptive use/uptake, adolescent sexual abstinence, pregnancy and myths and misperceptions about modern contraception.ConclusionSexual and reproductive health interventions have a positive impact on sexual and reproductive health outcomes. With the increasing popularity of mHealth coupled with the effectiveness of youth friendly health services, future youth SRH interventions could integrate both strategies to improve SRH services access and utilization.
Bone mineral density as an individual prognostic biomarker in NSCLC patients treated with immune checkpoint inhibitors
Authors: Lou Jie , Gong Bingxin , Li Yi , Guo Yusheng , Li Lin , Wang Jing , Liu Weiwei , You Ziang , Zhang Hongyong , Pan Feng , Liang Bo , Yang Lian , Zhou Guofeng 
Published: April 2024

BackgroundImmune checkpoint inhibitors (ICIs) have left a deep impression in the treatment of non-small cell lung cancer (NSCLC), however, not all patients benefit from it. The purpose of this study was to investigate the prognostic value of baseline bone mineral density (BMD) derived from chest computed tomography (CT) scans in NSCLC patients treated with ICIs.MethodsThis study included patients with advanced NSCLC who underwent ICI treatment at the Wuhan Union Hospital from March 2020 to October 2022. Baseline BMD was evaluated at non-contrast chest CT at the level of first lumbar vertebra. Patients were divided into BMD-lower group and BMD-higher group according to the optimal cutoff value calculated by X-tile software. Baseline characteristics of the two groups were compared and variables between the two groups were balanced by propensity score matching (PSM) analysis. We calculated the objective response rate (ORR) and disease control rate (DCR) of the two groups and analyzed overall survival (OS) and progression-free survival (PFS) using BMD and other clinical indexes through Cox regression models and Kaplan-Meier survival curves.ResultsA total of 479 patients were included in this study, and all patients were divided into BMD-lower group (n=270) and BMD-higher group (n=209). After PSM analysis, each group consisted of 150 patients. ORR (43.3% vs. 43.5% before PSM, P = 0.964; 44.7% vs. 44.7% after PSM, P = 1.000) and DCR (91.1% vs. 94.3% before PSM, P = 0.195; 93.3% vs. 96.7% after PSM, P =0.190) were similar in two groups. There was no statistically significant relationship between BMD degree and PFS before (16.0 months vs. 18.0 months, P = 0.067) and after PSM analysis (17.0 months vs. 19.0 months, P = 0.095). However, lower BMD was associated with shorter OS both before (20.5 months vs. 23.0 months, P&lt; 0.001) and after PSM analysis (20.0 months vs. 23.0 months, P = 0.008).ConclusionLower baseline BMD is associated with worse clinical outcomes in NSCLC patients treated with ICIs. As a reliable and easily obtained individual prognostic biomarker, BMD can become a routine detection indicator before immunotherapy.
Major endothelial damage markers identified from hemadsorption filters derived from treated patients with septic shock – endoplasmic reticulum stress and bikunin may play a role
Authors: Kasper Robin , Rodriguez-Alfonso Armando , Ständker Ludger , Wiese Sebastian , Schneider E. Marion 
Published: April 2024

IntroductionIn septic patients the damage of the endothelial barrier is decisive leading to circulatory septic shock with disseminated vascular coagulation, edema and multiorgan failure. Hemadsorption therapy leads to rapid resolution of clinical symptoms. We propose that the isolation of proteins adsorbed to hemadsorption devices contributes to the identification of mediators responsible for endothelial barrier dysfunction.Material and methodsPlasma materials enriched to hemadsorption filters (CytoSorb®) after therapy of patients in septic shock were fractionated and functionally characterized for their effect on cell integrity, viability, proliferation and ROS formation by human endothelial cells. Fractions were further studied for their contents of oxidized nucleic acids as well as peptides and proteins by mass spectrometry.ResultsIndividual fractions exhibited a strong effect on endothelial cell viability, the endothelial layer morphology, and ROS formation. Fractions with high amounts of DNA and oxidized DNA correlated with ROS formation in the target endothelium. In addition, defined proteins such as defensins (HNP-1), SAA1, CXCL7, and the peptide bikunin were linked to the strongest additive effects in endothelial damage.ConclusionOur results indicate that hemadsorption is efficient to transiently remove strong endothelial damage mediators from the blood of patients with septic shock, which explains a rapid clinical improvement of inflammation and endothelial function. The current work indicates that a combination of stressors leads to the most detrimental effects. Oxidized ssDNA, likely derived from mitochondria, SAA1, the chemokine CXCL7 and the human neutrophil peptide alpha-defensin 1 (HNP-1) were unique for their significant negative effect on endothelial cell viability. However, the strongest damage effect occurred, when, bikunin – cleaved off from alpha-1-microglobulin was present in high relative amounts (&gt;65%) of protein contents in the most active fraction. Thus, a relevant combination of stressors appears to be removed by hemadsorption therapy which results in fulminant and rapid, though only transient, clinical restitution.