bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sera from people with HIV and depression induce commensurate metabolic alterations in astrocytes: toward precision diagnoses and therapies
Authors: Laird Anna Elizabeth , Le Alexandra Anh , Kulbe Jacqueline R. , Umlauf Anya , Sagarian Melody , Spencer Matthew , Sathe Anish , Grelotti David J. , Iudicello Jennifer , Henry Brook , Ellis Ronald J. , Fields Jerel Adam 
Published: March 2024

Abstract

Objectives
People with HIV (PWH) have high rates of depression and neurocognitive impairment (NCI) despite viral suppression on antiretroviral therapy (ART). Mounting evidence suggests that immunometabolic disruptions may contribute to these conditions in some PWH. We hypothesized that metabolic dysfunction in astrocytes is associated with depressive symptoms and cognitive function in PWH.

Methods
Human astrocytes were exposed to sera from PWH (n=40) with varying degrees of depressive symptomatology and cognitive function. MitoTrackerTM Deep Red FM (MT) was used to visualize mitochondrial activity and glial fibrillary acidic protein (GFAP) as an indicator of astrocyte reactivity using the high-throughput fluorescent microscopy and image analyses platform, CellInsight CX5 (CX5). The Seahorse platform was used to assess glycolytic and mitochondrial metabolism.

Results
More severe depression, as indexed by higher Beck's Depression Inventory (BDI-II) scores, was associated with lower MT signal measures. Better cognitive function, as assessed by neuropsychiatric testing t-scores, was associated with increased MT signal measures. GFAP intensity negatively correlated with several cognitive t-scores. Age positively correlated with (higher) MT signal measures and GFAP intensity. Worse depressive symptoms (higher BDI-II scores) were associated with decreased oxygen consumption rate and spare respiratory capacity, concomitant with increased extracellular acidification rate in astrocytes.

Conclusions
These findings show that factors in the sera of PWH alter mitochondrial activity in cultured human astrocytes, suggesting that mechanisms that alter mitochondrial and astrocyte homeostasis can be detected peripherally. Thus, in vitro cultures may provide a model to identify neuropathogenic mechanisms of depression or neurocognitive impairment in PWH and test personalized therapeutics for neurologic and psychiatric disorders.
Flexible polymer networks: rubber elasticity and segmental orientation
Authors: Abetz Volker 
Published: March 2024

Abstract
Thermoreversible networks are very attractive materials because of a large variety of suitable thermoreversible chemical bonds which can be used for crosslinking. In future, to certain extent, they may replace so far used irreversibly crosslinked networks and contribute to more sustainable material concepts also in the field of crosslinked elastomers. This paper gives some theoretical basis for understanding the elastic deformation properties of crosslinked polymers and presents some experimental tools for studying deformation behavior not only on a macroscopic length scale but also on a segmental scale. Basic knowledge of these two topics is useful for chemists and material scientists when designing new sustainable elastomeric polymer networks.
Did People Really “Leave It Blank”? A Tale of What Became of the Census Citizenship Question and Allocation Trends Through Time
Authors: Smalley Heather Kitada , Karthik Mira 
Published: March 2024

Abstract
The 2020 Decennial Census garnered unprecedented attention due to the proposed reintroduction of the citizenship question by the Trump Administration. The legal imperative to respond to the Census and the sensitive nature of the citizenship question led to tensions and public outrage. This paper discusses the controversy surrounding the addition of the citizenship question and its implications on vulnerable communities, particularly undocumented immigrants and communities of color. Although the citizenship question was ultimately not added to the 2020 Decennial Census, it continued to be asked on the American Community Survey (ACS). We examine how negative public sentiment during this time, in tandem with historical mistrust of government data collection, may have manifested as item non-response within the ACS, specifically on questions relating to citizenship status and, more broadly, the Origin and Language subgroup of questions. The analyses in this paper explore trends in non-response rates from the American Community Survey from 2014 to 2022. Item allocation rates are used as a proxy for non-response to questions relating to citizenship. A variety of data visualization tools, supported by statistical methods, are employed to weave connections between allocation trends and the proposed addition of the citizenship question to the Decennial Census. We aim to bring transparency to this issue to educate and encourage response within vulnerable communities by emphasizing the importance of accurate data collection and positive perceptions of government-issued surveys, which are used to make key legislative decisions and create a more democratic nation.
Diversifikasi Produk Manjareal Tepung Tempe sebagai Jajanan Sehat Keluarga
Authors: Lestari Eni , Putri Meddiati Fajri , Triatma Bambang , Kuswardinah Asih 
Published: March 2024

Tujuan penelitian ini adalah : 1) Mengetahui tingkat kesukaan masyarakat terhadap produk manjareal subtitusi tepung tempe dengan formula 0%, 15%, 30%, dan 45%. 2) Mengetahui kadar air, protein dan lemak pada produk manjareal subtitusi tepung tempe dengan formula 0%, 15%, 30%, dan 45%. Desain eksperimen yang digunakan dalam penelitian ini adalah True Eksperimental. Metode analisis data yang digunakan adalah statistik deskriptif presentase dan uji laboratorium. Hasil penelitian ini menunjukkan: 1) Tingkat kesukaan masyarakat terhadap manjareal substitusi tepung tempe rata-rata berada pada kategori suka dengan rerata presentase total sebesar 73,75% (substitusi 0%, kontrol), 70,88% (substitusi 15%), 68,31% (substitusi 30%), dan 61,94% (substitusi 45%). 2) Uji kandungan air, protein dan lemak pada sampel substitusi tepung tempe 0% sebesar 4,8%, 13,6%, 30,8%. Sampel 15% sebesar 9,6%, 14,6%, 25,8%. Sampel 30% sebesar 16,6%, 17%, 23,1%. Sampel 45% sebesar 11,9%, 18,8%, 22%.
Addicted to socialising and still lonely: A comparative, corpus-driven analysis of problematic social networking site use
Authors: Kolas Janelle , von Mühlenen Adrian 
Published: March 2024

AbstractBackground and AimsProblematic Social Networking Site Use (PSNSU) is not a formally recognised addiction, but it is increasingly discussed as such in academic research and online. Taking a quantitative, exploratory approach, this study aims to (1) determine whether PSNSU is presented like clinically defined addictions by the affected community and (2) address how well measurements of PSNSU fit with the thematic content found within the associated discourse.MethodsFour corpora were created for this study: a corpus concerning PSNSU and three control corpora concerning established addictions, including Alcohol Use Disorder, Tobacco Use Disorder and Gaming Disorder. Keywords were identified, collocates and concordances were explored, and shared themes were compared.ResultsFindings show broad thematic similarities between PSNSU and the three control addictions as well as prominent interdiscursive references, which indicate possible confirmation bias among speakers.ConclusionsScales based upon the components model of addiction are suggested as the most appropriate measure of this emerging disorder.
Before the Flood
Authors: Jaine Tom 
Published: March 2024

This article looks at aspects of "Around Britain with Bon Viveur" (1952), the first of several guidebooks to home and abroad written by Fanny and Johnnie Cradock under their joint nom de plume of Bon Viveur, assumed when they started writing for the Daily Telegraph (and later for the Daily Mail). The brand extended over the next few years into recipe books as well, mostly published by or for the Telegraph, although the first of 1955 mentioned no affiliation, and there was another that was put out by the Gas Council. The article concentrates on their account of meals consumed on their way round the country. The details are sparse, readers were not really interested in gastronomic discussions such as we seem now to require, but the catalogue is sufficient to catch something of the character of public eating in Britain in 1952 (when rationing was still partly in force). This is followed by observations about various recent memoirs about life in the catering trade published between the 1940s and the 1980s.
Purgatory and Hell in Medieval Female Mystics’ Visions
Authors: Mąkosa Paweł 
Published: March 2024

Death and the afterlife have always evoked both fear and hope among people. Consequently, they have endeavoured to gain a deeper understanding of what lies beyond life’s earthly realm. Christian teachings and the official doctrine of the Church offer a broad overview of this reality, leaving room for an expectation of a more detailed explanation of the fate that awaits individuals after death. Female mystics, particularly those who lived during the late Middle Ages, played significant roles in elucidating these destinies. Their visions and subsequent writings contain a wealth of details concerning the nature of eternal life, providing meticulous descriptions of the places and events that unfold after death. This article delves into their visions of purgatory and hell, examining their relationship with the official Catholic doctrine.
Competences of an RE Teacher/Catechist in the Opinion of Schoolchildren
Authors: Słotwińska Helena , Buk-Cegiełka Marta , Mariański Janusz , Osewska Elżbieta , Rybarski Radosław , Stala Józef 
Published: March 2024

An important issue addressed in the presented article is the competencies of the RE teacher/ catechist. Two main problems are posed, summarized in the following questions: What competencies should a teacher of religion/catechist have? What qualities, according to secondary school pupils, should have an RE teacher? An attempt to answer such questions was made on the basis of an analysis of the literature on the subject and the results of a nationwide quantitative and qualitative study of secondary school pupils in Poland. The basic concepts of competence are discussed, groups of competencies relevant to the profession of religion teacher are characterized. Also presented are the results of research on the opinions of secondary school pupils regarding the person of a religion teacher/catechist.
The Analysis of Ukrainian Policy in the Field of State-Religious Education: Secondary School
Authors: Rohova Olena , Sychenko Viktor , Lysokolenko Tetiana 
Published: March 2024

The article provides an overview of approaches to the organization of religious education in secondary schools of Ukraine during the period of its independence, which complements the European experience of studying this issue. Attention is paid both to the historical circumstances of the beginning of school religious education in the interaction of religious, state and educational institutions, and to modern issues related to the policy of introducing subjects of religious and moral orientation in Ukrainian schools. The current legislation in the field of religious education in a secular school, the real practice of its implementation, and the challenges that give an idea of ​​the specifics of Ukraine in this matter in the European space, are analyzed. The legislative work of Ukraine on ­resolving the issue of legal regulation of the possibility of establishing educational institutions of different levels of accreditation by religious organizations is generalized. Statistical data on the state of teaching religious and moral subjects in schools of Ukraine are analyzed. Prospects and possibilities of further teaching of religious education in the Ukrainian public school are considered.
A Duty to Remain Connected: a Biblical Perspective of the Wisdom of the Shabbàt.
Authors: Sciberras Paul 
Published: March 2024

Our labour is intricately woven into our identity, extending beyond mere livelihood. It ought to facilitate personal growth, define our societal roles, and contribute to a common good within the confines of social and environmental sustainability. However, the contemporary work landscape is undergoing profound and global changes, disrupting traditional and conventional notions of work dynamics and its associated relationships. Amidst the diverse and country-specific alterations, a universal paradigm shift is reshaping nearly every sector of the economy. The pressing question emerges: How can we prevent the shift toward more flexible employment from translating into a life of perpetual instability? As job structures become more malleable and the boundaries between professional and personal life blur, the risks of self-exploitation and work-induced stress loom. In navigating these transformations, we must discern the evolving paradigms of work and consider their social and economic repercussions. What lessons are we being prompted to internalize as the European work landscape undergoes unprecedented changes? It becomes imperative to explore these shifts and their implications for a sustainable and equitable future. Exploring the existential insights of the Shabbàt and extracting valuable lessons from biblical wisdom prompts us to ponder the significance of rest in fostering healthy relationships and connectivity—with ourselves, others, our work, and our shared environment. The prevalent culture of constant availability and the obligation to stay connected could benefit from a biblical perspective, particularly in grasping the essence of Shabbàts wisdom.
Theologically Inspired and Supported Patriotism as a Component of Poland’s National Security. Concept of Research and its Social Application
Authors: Smuniewski Cezary , Urych Ilona , Boguszewski Mariusz 
Published: March 2024

The article presents a concept of research and its social application concerning the creation and modelling of theologically inspired and supported patriotic attitudes in the Polish historical and security-related context. It concerns patriotism which, primarily, refers to Poland’s national heritage, theology, Catholic social science and national responsibility; secondly, it is directed at a sovereign economic development locally and on the international arena; thirdly, it shapes pro-societal and pro-defence attitudes; fourthly, it takes into account contemporary challenges linked with the environment, demography, migrations and “temporal challenges”. The text is classified among the papers on conceptualization of research projects in the area of security studies, social policies and political science, account being taken of the contexts and problem references to theology, history and cultural anthropology.
St. Peter, Church and Religion as a Role Model for Modern Entrepreneurs
Authors: Borowski Piotr F. 
Published: March 2024

Modern enterprises operate on the basis of the Industry 4.0 paradigm. Technology is becoming an inherent attribute of the economy, but at the same time, one should bear in mind the employees, who create enterprises, and the spiritual side, so as to maintain a balance between what is tangible and intangible. Religion and spirituality are intertwined and have an impact on business practice and corporate management. Research on a group of young people has shown that faith plays a vital role in running a business. Moreover, the sustainability and uninterrupted activity of the Church can be a model for many companies. Subordinating one’s own affairs and individual ambitions to the common good and higher values, is the direction which managers of modern institutions can follow. Such an enterprise needs a leader, a charismatic leader who, as an intangible asset, will primarily see the value of the employees entrusted to him, and only then, the material value of the company. The personnel function and the humanistic approach are the key aspects of a well-functioning enterprise. The article analyses the role of St. Peter in managing the Church, and indicates the possibility of managing modern enterprises based on Church experience.
Application of Catholic Social Teaching in Finance and Management
Authors: Czerwonka Monika , Pietrzak Maria 
Published: March 2024

In dominating narratives, economics has been portrayed as hard science, based on complex mathematical equations and rigid statistical models. It seems to be overlooked that it belongs to the domain of social sciences and that its roots stem from philosophy and ethics. After all, many classical economists were either ethicists (A. Smith) or clergymen (T. Bayes). Today’s managers also seem to be motivated mainly by the desire to increase their company’s profits. However, if managers wish to become both effective and respected leaders for their teams, they should build their power on ethical principles deeply rooted in Catholic Social Teaching. The purpose of the present paper is to attract attention to the relation of economics, management and religion. Behavioral economics and management come to our aid here by emphasizing that, when making decisions related not only to financial markets but also to managerial tasks, what matters is not only factors that are strictly financial, but also those are related to psychology or ethics. Using the example of ethical investing and faith-based funds or stock indexes the Authors show that Christian values and the social teaching of the Catholic Church are still important to some participants in the financial markets.
Implementasi Penataan Toko Modern dan Pemberdayaan Pasar Tradisional
Authors: Ayunda Citra Lestari  
Published: March 2024

Fenomena yang terjadi yakni banyak toko modern berdekatan dengan Pasar Bronggalan, Kelurahan Pacar Kembang, Kecamatan Tambaksari, Kota Surabaya. Tujuan penelitian adalah untuk menjelaskan secara aktual dan faktual mengenai Implementasi Pemberdayaan Pasar Modern dan Pasar Tradisional serta mengetahui faktor-faktor yang mendukung dan menghambat Implementasi Penataan Toko Modern dan Pemberdayaan Pasar Tradisional. Metode penelitian ini menggunakan penelitian kualitatif-studi kasus dengan satu variabel yaitu, Implementasi Pemberdayaan Pasar Modern dan Pasar Tradisional (Studi Kasus Alfamart, Alfamidi, Indomaret, dan Pasar Bronggalan, Keluahan Pacar Kembang, Kota Surabaya).
Dalam Implementasi Penataan Toko Modern dan Pemberdayaan Pasr Tradisional Studi Kasus di Alfamart, Alfamidi, Indomaret, dan Pasar Bronggalan, Kelurahan Pacar Kembang, Kecamatan Tambaksari, Kota Surabaya), dipengaruhi oleh enam faktor diantaranya, standar/ukuran kebijakan, komunikasi, sumber daya, disposisi, dan struktur birokrasi, dan kondisi sosial, ekonomi, dan politik. Faktor pendukung kebijakan implementasi pemberdayaan Alfamart, Alfamidi, Indomaret, dan Pasar Bronggalan yakni Koordinasi Dinas Perdagangan Kota Surabaya dan PD Pasar Surya Surabaya dan Pemerataan. Sedangkan faktor penghambatnya ialah kesadaran yang rendah dan pengawasan belum optimal
Electro‐clinical evolution of refractory non‐convulsive status epilepticus caused by West Nile virus encephalitis
Authors: Bagic Anto , Boudreau Eilis A. , Greenfield Jacquelyn , Sato Susumu 
Published: March 2024

ABSTRACT
West Nile virus (WNV) has re‐emerged with a much wider geographic distribution and a higher incidence than ever. In spite of some recent reports on the neurological manifestations and EEG changes caused by WNV encephalitis, there are few data on the incidence of seizures, status epilepticus or post‐encephalitic epilepsy. There is also no systematic review of EEG changes caused by WNV encephalitis that is based on a large series of patients. Here, we review the pertinent literature, and report the electroclinical evolution and therapeutic complexity of a patient with WNV encephalitis who developed refractory, non‐convulsive status epilepticus.
Dissociation between
in vitro
and
in vivo
epileptogenicity in a rat model of cortical dysplasia
Authors: Kellinghaus Christoph , Möddel Gabriel , Shigeto Hiroshi , Ying Zhong , Jacobsson Berit , Gonzalez‐Martinez Jorge , Burrier Candice , Janigro Damir , Najm Imad M. 
Published: March 2024

ABSTRACT

Objective.

Malformations of cortical development are frequent causes of human refractory epilepsy. The freeze‐lesion model in rats shows histopathological features similar to those found in human polymicrogyria. Previous studies reported
in vitro
hyperexcitability in this model, but
in vivo
epileptogenicity has not been confirmed.

Methods

Neocortical freeze lesions were induced in Sprague‐Dawley rat pups (n = 10) on postnatal day 0 or 1 (P0/P1). Sham‐operated animals served as controls (n = 10). On P60, animals were implanted with epidural electrodes for long‐term video‐EEG monitoring (4 weeks). The threshold for pentylenetetrazolinduced seizures was determined. Animals were sacrificed and brain sections processed for histological staining and
in vitro
electrophysiological recordings. Epileptiform field potential repetition rate, amplitude and integral were compared between slices containing a cortical freeze lesion, and slices from sham‐operated rats.

Results

No interictal spikes and no electrographic or clinical seizures occurred in either group. The median threshold for pentylenetetrazol‐induced seizures was 60 mg/kg for lesioned, and 45 mg/kg for control animals (difference not significant). No spontaneous epileptiform field potentials were recorded from either freeze‐lesion or control slices bathed in normal, artificial cerebrospinal fluid (ACSF). Upon omission of Mg
2+
from the bath, epileptiform field potentials were elicited that showed a significantly higher burst integral in the freeze lesion slices compared to control slices.

Conclusion

Neocortical freeze lesions induced in newborn rat pups show histological characteristics reminiscent of human cortical dysplasia. Brain slices containing neocortical freeze lesions display hyperexcitability
in vitro
, but the same lesion does not appear to show spontaneous epileptogenicity
in vivo
.
Depression in epilepsy: phenomenology, diagnosis and management
Authors: Seethalakshmi R. , Krishnamoorthy Ennapadam S. 
Published: March 2024

ABSTRACT
1) Depression is a common and important accompaniment of epilepsy. 2) Depression in epilepsy is phenomenologically different from the usual forms of depression and it is essential that treating physicians assess for these varied forms as well. 3) Depression in epilepsy may be managed more effectively if the relationship to the ictus is better understood. 4) Other factors such as stressful life events, related or unrelated to epilepsy, may contribute to the depressive symptoms. 5) Antiepileptic drugs, particularly GABAergic agents such as vigabatrin, tiagabine, topiramate and phenobarbitone are depressogenic in nature. 6) The newer antidepressants, SSRIs such as sertraline, citalopram and paroxetine do not lower seizure threshold and can be safely used to treat depression in epileptic individuals. Fluoxetine may be avoided because of its longer half‐life.