bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tendon calcifications in chondrocalcinosis
Authors: Gerster Jean C. , Boussina Iradj , Baud Charles A. , Lagier Rene , Fallet Georges H. 
Published: February 2007

AbstractFine linear extraarticular calcium deposits were found in X‐rays of 7 of 52 patients with articular chondro‐calcinosis (ACC). Seven Achilles tendons, seven quadriceps tendons, and one plantar fascia were affected. In a control group of comparable age and sex, without ACC but with generalized osteoarthritis, no calcifications were found in the tendons. On a biopsy specimen of an Achilles tendon with such calcium deposits, X‐ray diffraction showed that they had the characteristics of calcium pyro‐phosphate dihydrate. Isolated small foci of crystals were observed on some segments of tendon bundles. The presence of fine linear calcifications on X‐rays of the Achilles or quadriceps tendons may be a useful aid in the radiologic diagnosis of so‐called articular chondrocalcinosis.
Antiglobulins in juvenile rheumatoid arthritis
Authors: Miller John J. , Olds‐Arroyo Lynne , Akasaka Toru 
Published: February 2007

AbstractWith initial hopes of establishing a diagnostic test for juvenile rheumatoid arthritis (JRA), five types of immunoadsorbents were used to search for occult antiglobulins in sera from children. The immunoadsorbents included glutaraldehyde‐aggregated globulin, heat‐ and glutaraldehyde‐aggregated globulin, Affi‐Gel‐bound globulin, Sepharose‐bound globulin, and bromoacetyl cellulose‐bound globulin. The glutaraldehyde‐aggregated immunoadsorbents retained nonspecific protein. The Affi‐Gel, Sepharose, and bromoacetyl cellulose adsorbents were effective and specific, but the Affi‐Gel and bromoacetyl cellulose were impractical for routine use. Sepharose‐bound globulin was selected for use in a survey of 52 patients with JRA and 8 normal children. Materials resembling occult antiglobulins, measured as acid elutable protein, were found in normal children as well as in children with JRA. Only a small proportion of children with JRA had statistically elevated levels of such occult anti‐globulins. The protein adsorbed to Sepharose‐bound globulin consisted of IgM, IgG, and IgA, and had latex fixation activity in 2 of 5 tested sera from normal children and in 27 of 52 sera from children with JRA. Thus the presence of antiglobulins per se is not diagnostically helpful in distinguishing children with JRA.
Acetylator phenotype in systemic lupus erythematosus
Authors: Foad Baher , Litwin Allen , Zimmer Hans , Hess Evelyn V. 
Published: February 2007

AbstractThe acetylation rate of sulfamethazine was studied in 25 patients with systemic lupus erythematosus (SLE). Seventeen of 25 SLE patients, 68%, were slow acetylators compared to the reported incidence of 52% in the general population. There was no correlation between the acetylator phenotype in SLE patients and the various clinical manifestations or the activity of the disease. Lupus patients who were slow acetylators had a lower lymphocyte response to phytomitogens compared to rapid acetylators.
Connective tissue synthesis by cultured scleroderma fibroblasts
Authors: Bashey Reza I. , Perlish Jerome S. , Nochumson Susan , Stephens Ralph E. , Fleischmajer Raul 
Published: February 2007

AbstractFibroblasts from normal and scleroderma skin, grown in tissue culture, were incubated with 3H‐glucosamine for 24 hours. No definite trends could be established in 3H‐glucosamine incorporation or glycosaminoglycan synthesis. Over 90% of the total 3H activity as well as the glycosaminoglycans synthesized were secreted into the medium. Characterization of glycosaminoglycans showed that in both the medium and cells, hyaluronic acid is the major glycosaminoglycan in normal and scleroderma fibroblasts. In the medium, hyaluronic acid represented 87% of the total glycosaminoglycans; it was slightly decreased in the cells. Fibroblasts were compared from the upper and lower areas of the affected dermis and an uninvolved dermal area of the same scleroderma patient.
Lymphocytotoxic antibodies
Authors: Raum Donald , Glass David , Soter Nicholas A. , Stillman J. Sydney , Carpenter Charles B. , Schur Peter H. 
Published: February 2007

AbstractLymphocytotoxic antibodies (LCTAB) were sought in sera of patients with rheumatic diseases and in family members. Patients with SLE and cutaneous necrotizing venulitis and family members of JRA patients had an increased frequency of LCTAB; JRA patients and family members of SLE patients did not. The only association between LCTAB and the HLA phenotype of persons with LCTAB was a decreased frequency of LCTAB in individuals with HLA‐B27.
Ecchymosis of the lower leg
Authors: Good Armin E. , Pozderac Rodney V. 
Published: February 2007

AbstractFour patients with hemarthrosis of the knee, synovial rupture, and ecchymoses are reported. The patients presented with calf pain and swelling and large ecchymoses, which eventually extended to the ankle as a crescent about one or both malleoli. Appreciation of this physical sign, which appears to be characteristic for the hemorrhagic subset of synovial rupture, should alert the physician to the correct diagnosis and steer him away from contraindicated anticoagulant therapy.
Nucleographic Studies of Axial Spondarthritides I. Quantitative Sacroiliac Scintigraphy in Early HLA‐B27‐Associated Sacroiliitis
Authors: Namey Thomas C. , Mcintyre John , Buse Maria , Leroy E. C. 
Published: February 2007

AbstractQuantitative sacroiliac scintigraphy (QSS) was performed on 34 patients suspected of having ankylosing spondylitis (AS) with low back pain and stiffness of recent onset, by utilizing three technical features not previously described: fractional scintigraphy of the sacroiliac (SI) joints, background subtraction, and drug washout. Imaging was performed with a 140‐keV, high‐resolution collimator, and the data were recorded and processed with an Ohio Nuclear 150 System, 3 hours after administration of 17 mCi of 99m Tc ethane‐1‐hydroxy‐1, 1‐diphosphonate (EHDP) per 70 kg of body weight. The SI index determined by QSS was compared with diagnostic tissue‐typing for HLA–B27 and standard radiography of the SI joints to assess the potential of QSS to discriminate inflammatory sacroiliitis from nonspecific low back strain. Twenty‐three of the 34 patients were positive for HLA–B27 and they had a mean index by QSS of 2.09. All but 1 had an index exceeding 1.7. Only 5 of these B27‐positive patients had early radiographic sacroiliitis. The 11 B27‐negative patients had a mean index by QSS of 1.52, and none had radiographic sacroiliitis. The mean values for 46 controls and 10 patients with classic AS, B27 positivity, and complete sclerosis of their SI joints were 1.32 and 1.38, respectively, suggesting that the elevated SI indices found by QSS in the symptomatic B27‐positive patients do reflect inflammatory sacroiliitis. Five of the recently symptomatic B27‐positive patients with elevated indices had repeat QSS after 3 weeks of therapy with conventional antiin‐flammatory drugs and had a reduction in their SI index. QSS appears to be useful in detecting inflammatory sacroiliitis associated with B27 positivity before the development of radiographic disease, and it may be an objective tool in assessing the short‐term therapy of inflammatory sacroiliitis.
Pulmonary Function in Scleroderma
Authors: Guttadauria Maria , Ellman Herman , Emmanuel George , Kaplan David , Diamond Herbert 
Published: February 2007

AbstractPulmonary function tests were performed in 45 patients with scleroderma. Thirteen patients (29%) were found to have restrictive disease, 12 patients (27%) were found to have obstructive disease, and 19 patients (42%) had small airway disease (SAD). Smoking did not seem to be a factor underlying either obstructive or small airway disease in these patients. A low diffusing capacity was most common in patients with restrictive disease and rarely the only abnormality in pulmonary function. SAD was usually found in patients who had normal chest radiographs and no pulmonary symptoms and was often the only abnormality. SAD is therefore an early and sensitive indicator of pulmonary involvement in scleroderma.
Surface Ultrastructure of Rheumatoid Articular Cartilage
Authors: Kimura Hiroshi , Tateishi Hiroomi , Ziff Morris 
Published: February 2007

AbstractSix rheumatoid articular cartilage specimens, which appeared grossly normal and were shown to be free of pannus when examined under the light microscope, were examined electron microscopically. For comparison, normal‐appearing cartilage specimens from 2 patients with meniscus injury and 2 with degenerative joint disease (DJD) were also examined. In all cases the normal‐appearing joint surface of rheumatoid cartilage was abnormal. Amorphous‐appearing material was present to a depth varying between 6 and 25 m̈m. Some of this material had the appearance of fibrin deposited at the cartilage surface, but much appeared to represent breakdown products of the cartilage matrix, i.e. degraded collagen and proteoglycan. DJD cartilage did not show similar changes. The findings suggest that the surface of rheumatoid articular cartilage, even when grossly normal in appearance, is degraded by enzymes either present in the synovial fluid or released by polymorphonuclear cells in close contact with the cartilage surface.
Hip Joint Restoration in Juvenile Rheumatoid Arthritis
Authors: Bernstein Bram , Forrester Deborah , Singsen Bernhard , King Karen Koster , Kornreich Helen , Hanson Virgil 
Published: February 2007

AbstractSix children with long‐standing juvenile rheumatoid arthritis and radiographic evidence of severe hip joint damage were found 6 months to 5 years afterward to have radiographic evidence of significant hip joint space widening and remodeling of articular surfaces. The disease activity had decreased and hip joint function had improved in all children. Each child had received various antiinflammatory drugs, but no specific medication could be implicated in the improvement. Evidence from animal studies suggests that intensive physical therapy with emphasis on continued weight bearing may have been important in promoting healing in these children. It appears that restoration of severely damaged hip joints in JRA can occur when the disease activity is controlled. Restoration may be favored by a child's greater potential for bone remodeling and by vigorous physical therapy with emphasis upon continued ambulation.
Chronic Nondestructive Arthritis Associated with Cutaneous Polyarteritis
Authors: Smukler Nathan M. , Schumacher H. Ralph 
Published: February 2007

AbstractTwo patients with arthritis of the knee joints associated with cutaneous polyarteritis have been followed for 20 and 5 years. The arthritis is characterized by mild to moderate pain and stiffness and inflammatory joint effusions with predominantly polymorphonuclear leukocytes. Despite its chronicity, there has been no clinical or radiologic evidence of joint destruction. Necrotizing inflammation was seen in arteries of the deep skin but not in the small vessels observed in the synovial biopsy specimens.
Comparison of Two Dosage Schedules of Gold Salts in the Treatment of Rheumatoid Arthritis
Authors: Sharp John T. , Lidsky Martin D. , Duffy Joseph , Thompson Howard K. , Person Blanche D. , Masri A. Fattah , Andrianakos Alexander A. 
Published: February 2007

AbstractTwo doses of gold sodium thiomalate were compared for their effect on rheumatoid arthritis. Thirty‐seven patients with active disease for longer than 6 months were treated with 25 mg of gold sodium thiomalate for an average of 29.6 weeks, then at biweekly or monthly intervals to complete 2 years of treatment. Thirty‐eight patients were given more than twice as much gold salt at the same intervals on a flexible dose schedule that produced serum gold levels which averaged 332 μUg/dl during the weekly injection phase. No differences were observed in the therapeutic responses of the two groups. Therefore the minimal dose of gold sodium thiomalate required to induce a response in rheumatoid arthritis is 25 mg or less per week. Serum gold levels in the steady state varied between 95 and 386 m̈g/dl and were not related to response. Serum half‐life for gold was calculated for patients who had an excellent response and for those who were treatment failures. The rate at which gold disappeared from serum was not related to therapeutic response.
Secretion of Plasminogen Activator by Rheumatoid and Nonrheumatoid Synovial Cells In Culture
Authors: Berger Henry , Fleming Patricia R. , Voorhees Patricia R. 
Published: February 2007

AbstractThe secretion of plasminogen activator by human synovial cultures established from explants was studied. Thirteen cultures established from patients with rheumatoid disease were hyposecretors of plasminogen activator. Seven cultures derived from patients with nonrheumatoid joint disorders all secreted high levels of this enzyme. Rheumatoid and nonrheumatoid cells contained comparable levels of intracellular activator. It is suggested that the secretion of plasminogen activator is a function of normal synovium and that a defect in this function in the rheumatoid synovium perpetuates the inflammatory process.
Pathogenesis of Cervical Discovertebral Destruction in Rheumatoid Arthritis
Authors: Martel William 
Published: February 2007

AbstractA review of 20 cases of rheumatoid arthritis strongly supported the concept that the cervico‐disco‐vertebral destruction seen radiologically is a consequence of cervical instability caused by apophyseal arthritis and ligamentous laxity. It is postulated that such instability results in chronic trauma to the discovertebral joints leading to destruction of the disc cartilage and vertebral end‐plates. “Rheumatoid inflammation” of the disc has previously been described, but it is uncertain that such inflammation in the disc is the primary cause of these destructive lesions.
Yersinia‐Related Arthritis in the Pacific Northwest
Authors: Ford Denys K. , Henderson Elizabeth , Price George E. , Stein Howard B. 
Published: February 2007

AbstractSerologic evidence of Yersinia enterocolitica infection was sought by agglutination testing in serum samples from several populations, including Haida Indians, Red Cross blood donors, and Caucasian patients with rheumatoid arthritis, ankylosing spondylitis, and Reiter's syndrome. No evidence was found to indicate that yersinial infection was etiologically related to Haida spondylitis or Reiter's syndrome. Four of 28 patients with acute arthritis were diagnosed from serologic evidence as having Yersinia‐related arthritis.
Cathepsin D Agglutinators and Neutral Protease Agglutinators in Rheumatoid Arthritis
Authors: Fehr K. , Artmann G. , Velvart M. , Bŉni A. 
Published: February 2007

AbstractTissue culture methods demonstrated the production of agglutinators against the cathepsin D site in IgG (CDA) and a neutral protease site in IgG (NPA) by rheumatoid synovial tissue. Seven of 11 specimens from seropositive and 2 of 7 specimens from seronegative RA patients were positive for CDA, whereas 2 of 11 specimens from seropositive and 1 of 7 specimens from seronegative patients were positive for NPA. None of the 6 control specimens was positive for both types of agglutinators. Chromatography of two synovial tissue incubates showed that the CDA were of the IgG type. By the immunofluorescence technique, plasma cells containing CDA were demonstrated in rheumatoid synovial tissue and draining lymph nodes of rheumatoid joints. The staining for CDA in the synovium was different from the staining for pepsin agglutinators in adjacent sections. Phagolysosomes containing CDA were found in synovial exudate cells from rheumatoid patients as well as in phagocytosing lining cells and macrophages of the sublining layer of rheumatoid synovial tissue. These findings suggest that antibodies directed at hidden antigenic sites in IgG revealed by endogenous proteolysis take part in the immune reaction and in the inflammation of rheumatoid joints.
Failure of Proteoglycans to Form Aggregates in Morphologically Normal Aged Human Hip Cartilage
Authors: Perricone Elaine , Palmoski Marshall J. , Brandt Kenneth D. 
Published: February 2007

AbstractThe macromolecular organization of proteoglycans in morphologically and histochemically normal hip cartilage from aged humans has been studied. In contrast to findings in articular and nonarticular cartilage from other sources, most of the proteoglycans in these tissues did not exist in large aggregates. Treatment with hyaluronic acid β1 → 3 hydrolase failed to diminish the size of proteoglycans prepared under conditions favoring aggregation, a finding suggesting that they were not complexed with hyaluronic acid. Polyacrylamide gel electrophoresis failed to demonstrate the presence of link glycoproteins associated with the proteoglycans. After incubation in vitro with hyaluronic acid, minimal augmentation of hydrodynamic size of the preparation occurred, an indication that hyaluronate‐proteoglycan interaction had not taken place. These results suggest that proteoglycan aggregation was diminished because of a defect in the core protein of the proteoglycans resulting in an impaired ability of these molecules to interact with hyaluronic acid.
Estimates of Doses of Antiinflammatory Drugs in Man by Testing for Analgesic Potency
Authors: Kantor T. G. , Streem A. , Laska E. 
Published: February 2007

AbstractDosage estimates of antiinflammatory drugs in human arthritis Phase II trials are difficult to obtain and prolong such trials unnecessarily. Antiinflammatory drugs almost always have analgesic properties in man and good dose estimates for analgesic activity can be obtained.In 140 patients with surgical pain, 300, 600, and 1200 mg of aspirin were compared to 75, 150, and 300 mg of 43–715 (1–isopropyl–4 phenyl–7–methyl–2 (1H) quinazolone), an antiinflammatory quinazolone derivative, for analgesia in a double—blind trial using subjective response methodology. The test drug was shown to be analgesic at a level four times more potent, milligram for milligram, than aspirin, an estimate that should be useful for later definitive Phase II trials in arthritis.
Treatment of rheumatoid arthritis with levamisole
Authors: Runge Lorne A. , Pinals Robert S. , Lourie Seth H. , Tomar Russell H. 
Published: February 2007

AbstractLevamisole, an anthelminthic agent with immuno‐stimulatory properties, was used in a double‐blind, controlled therapeutic trial in rheumatoid arthritis. Patients received either levamisole 100 mg 4 days a week, or placebo, for a period of 4 months. Significant improvement in the treated group, as compared with the control group, was found in the number of tender and swollen joints, grip strength, range of joint motion, sedimentation rate, and C‐reactive protein. On double‐blind global evaluation by the examining physicians, 9 of 14 patients on levamisole and none of 13 on placebo were considered to have improved. Adverse effects did not differ in frequency between the two groups except for mild alteration in taste, which was more common with levamisole.
Lymphocyte activation in rheumatoid synovial effusion
Authors: Sebök J. , Talerman A. , Wouters H. W. 
Published: February 2007

AbstractA rapid method based upon increase in intranuclear birefringence occurring in early stages of lymphocyte activation was used to examine whether there is any difference in lymphocyte activation between lymphocytes from synovial fluid and those from peripheral blood in patients with rheumatoid arthritis and other joint diseases. Increased activation of synovial fluid lymphocytes compared with peripheral blood lymphocytes was seen only in synovial effusions obtained from patients with rheumatoid arthritis.
Septic arthritis of the glenohumeral joint
Authors: Master Robert , Weisman Michael H. , Armbuster Thomas G. , Slivka Jack , Resnick Donald , Goergen Thomas G. 
Published: February 2007

AbstractSeven patients (eight shoulders) with sepsis of the glenohumeral joint were studied clinically and radio‐graphically. Despite the advanced age of the patients, the presence of gram‐negative organisms, and multiple risk factors in each patient (including serious chronic underlying diseases), needle drainage and parenteral antibiotics were all that were required for successful management, provided early diagnosis with prompt institution of antibiotics and drainage occurred. Contrast arthrography safely guided therapy and revealed rotator cuff tears in four of six shoulders as well as frequent extra‐articular extensions of the disease. A nonleukemic patient with Aero‐monas hydrophilia sepsis and arthritis is reported who survived with eradication of infection and preservation of joint function. A poor prognosis for shoulder sepsis is not substantiated.
Destruction of joint homografts
Authors: Yablon Isadore G. , Brandt Kenneth D. , Delellis Ronald , Covall David 
Published: February 2007

AbstractThe host synovium undergoes a striking transformation at about 26 weeks after joint homografting. Histologically the synovium invaded and destroyed the graft with which it came in contact, becoming markedly hypercellular; the infiltrate consisted mainly of plasma cells and lymphocytes. The synovium at this stage closely resembled a rheumatoid pannus. The cartilage in contact with this invasive synovium lost its staining qualities, failed to take up S‐35, and was gradually destroyed. The mechanism causing this transformation remains unclear. It is postulated that these changes could be due to an inflammatory or immune response.
Migrainous phenomena in systemic lupus erythematosus
Authors: Brandt Kenneth D. , Lessell Simmons 
Published: February 2007

AbstractEleven patients with systemic lupus erythematosus (SLE) also had headaches and/or visual hallucinations typical of those found in migraine. These migrainous symptoms were commonly associated with exacerbations of SLE and abated as disease activity subsided. In some cases corticosteroids were more effective than conventional antimigraine therapy in controlling headaches and scotomas. The data suggest that migraine‐like phenomena may arise as a result of vascular dysfunction in SLE.
Direct evidence for circulating dna/anti‐dna complexes in systemic lupus erythematosus
Authors: Davis John S. , Godfrey Stephania M. , Winfield John B. 
Published: February 2007

AbstractFifteen serum cryoprecipitates from 28 patients with systemic lupus erythematosus (SLE) contained DNA demonstrable by counterimmunoelectrophoresis after exhaustive digestion of cryoimmunoglobulin with pronase. The majority of these cryoprecipitates also exhibited increased DNA binding activity in a modified Farr assay. Both DNA and anti‐DNA antibody were enriched in the cryoprecipitates relative to the supernatant serum level. These data provide direct evidence for the presence of DNA/anti‐DNA complexes in the circulation of patients with SLE.
Association between HLA‐BW38 and peripheral psoriatic arthritis
Authors: Espinoza L.R. , Vasey F.B. , Oh J.H. , Wilkinson R. , Osterland C.K. 
Published: February 2007

AbstractThe frequency distribution of HLA antigens was studied in a group of psoriatic patients with and without arthritis. HLA‐BW38 was found significantly increased in the group with peripheral psoriatic arthritis. There were no differences in the clinical features of the arthritis in the BW38 positive (+) and BW38 negative (‐) individuals. It is suggested that BW38 is a genetic marker and/or an indicator of peripheral joint involvement in psoriatic patients.