bluuebunny/crossref_metadata_2025_split huggingface dataset:
Distinct Regulation of ASCL1 by the Cell Cycle and Chemotherapy in Small Cell Lung Cancer
Authors: Liu Yuning , Wu Qingzhe , Jiang Bin , Hou Tingting , Wu Chuanqiang , Wu Ming , Song Hai 
Published: March 2024

Abstract

Small cell lung cancer (SCLC) is an aggressive and lethal malignancy. Achaete-scute homolog 1 (ASCL1) is essential for the initiation of SCLC in mice and the development of pulmonary neuroendocrine cells (PNEC), which are the major cells of origin for SCLC. However, the regulatory mechanism of ASCL1 in SCLC remains elusive. Here, we found that ASCL1 expression gradually increases as the tumors grow in a mouse SCLC model, and is regulated by the cell cycle. Mechanistically, CDK2–CyclinA2 complex phosphorylates ASCL1, which results in increased proteasome-mediated ASCL1 protein degradation by E3 ubiquitin ligase HUWE1 during mitosis. TCF3 promotes the multisite phosphorylation of ASCL1 through the CDK2–CyclinA2 complex and the interaction between ASCL1 and TCF3 protects ASCL1 from degradation. The dissociation of TCF3 from ASCL1 during mitosis accelerates the degradation of ASCL1. In addition, chemotherapy drugs greatly reduce the transcription of ASCL1 in SCLC cells. Depletion of ASCL1 sensitizes SCLC cells to chemotherapy drugs. Together, our study demonstrates that ASCL1 is a cell-cycle–regulated protein and provides a theoretical basis for applying cell-cycle–related antitumor drugs in SCLC treatment.
Implications:Our study revealed a novel regulatory mechanism of ASCL1 by cell cycle and chemotherapy drugs in SCLC. Treating patients with SCLC with a combination of ASCL1-targeting therapy and chemotherapy drugs could potentially be beneficial.
Remnant Cholesterol, Not LDL Cholesterol, Explains Peripheral Artery Disease Risk Conferred by apoB: A Cohort Study
Authors: Wadström Benjamin N. , Pedersen Kasper M. , Wulff Anders B. , Nordestgaard Børge G. 
Published: March 2024

BACKGROUND:
Elevated apoB-containing lipoproteins (=remnants+LDLs [low-density lipoproteins]) are a major risk factor for atherosclerotic cardiovascular disease, including peripheral artery disease (PAD) and myocardial infarction. We tested the hypothesis that remnants and LDL both explain part of the increased risk of PAD conferred by elevated apoB-containing lipoproteins. For comparison, we also studied the risk of chronic limb-threatening ischemia and myocardial infarction.

METHODS:
apoB, remnant cholesterol, and LDL cholesterol were measured in 93 461 individuals without statin use at baseline from the Copenhagen General Population Study (2003–2015). During up to 15 years of follow-up, 1207 had PAD, 552 had chronic limb-threatening ischemia, and 2022 had myocardial infarction in the Danish National Patient Registry. Remnant and LDL cholesterol were calculated from a standard lipid profile. Remnant and LDL particle counts were additionally measured with nuclear magnetic resonance spectroscopy in 25 347 of the individuals. Results were replicated in 302 167 individuals without statin use from the UK Biobank (2004–2010).

RESULTS:
In the Copenhagen General Population Study, multivariable adjusted hazard ratios for risk of PAD per 1 mmol/L (39 mg/dL) increment in remnant and LDL cholesterol were 1.9 (95% CI, 1.5–2.4) and 1.1 (95% CI, 1.0–1.2), respectively; corresponding results in the UK Biobank were 1.7 (95% CI, 1.4–2.1) and 0.9 (95% CI, 0.9–1.0), respectively. In the association from elevated apoB to increased risk of PAD, remnant and LDL cholesterol explained 73% (32%–100%) and 8% (0%–46%), respectively; corresponding results were 63% (30%–100%) and 0% (0%–33%) for risk of chronic limb-threatening ischemia and 41% (27%–55%) and 54% (38%–70%) for risk of myocardial infarction; results for remnant and LDL particle counts corroborated these findings.

CONCLUSIONS:
PAD risk conferred by elevated apoB-containing lipoproteins was explained mainly by elevated remnants, while myocardial infarction risk was explained by both elevated remnants and LDL.
Death—The Gift of God to Man
Authors: Juričková Martina 
Published: March 2024

Abstract
In his Middle-earth lore, Tolkien presents death as a special gift that Eru gave to Men alone, and not any other beings. This paper tries to answer why death can be understood as a gift even by us, even though this idea seems to contradict the traditional belief that death is a punishment for the sin of the first people in Paradise. As unorthodox as it may seem, this paper suggests that it might have been inspired by Aquinas, who presented death as an essential attribute of the human body given to it from the moment of creation, but which in Paradise was only suppressed by a special grace from God. Aquinas suggests that after the introduction of sin to the world, this grace was removed and death regained its appointed effect. Death actually became a necessary means through we are able to come back to God’s presence—thus in a sense, it is a gift.
Visualizing Buddhism Today
Authors: Kim Mina 
Published: March 2024

Abstract
Since Buddhism appeared around the fifth century BCE, it has established itself as a discipline that gives philosophical teachings to many people beyond religion. After the twentieth century, Buddhism has gone beyond being a representative ideology of the East and continues to be a social and cultural inspiration for many people worldwide. By focusing on the artworks of three Korean artists, Jeong Hwa Choi, Kimsooja, and Do Ho Suh, this study explores in detail how Buddhism inspires artists to visualize self-reflection and transnational identity and how traditional Buddhism contributes to the universalization, conceptualization, and communication of contemporary art. It also discusses how Buddhism is being reinterpreted and visualized by contemporary artists today, becoming a work of art for the public, not art for the few. Their artworks, inspired by Buddhism, show how contemporary art shows humanist, participatory, empathic, diverse, and global aspects and conveys multilayered messages.
Effect of silicon application on rice plant defence against brown planthopper feeding under climate change conditions
Authors: Tenguri Prabhulinga , Chander Subhash , Ellur Ranjith Kumar , Patil Eresh , Sundaran Arya Pattathanam , Yele Yogesh , Thube Shivaji H. , Naik V. Chinna Babu , Nagaraju Madhu Tadagavadi 
Published: March 2024

Abstract
Silicon (Si) is known to enhance plant resistance in rice and other Poaceae plants by priming chemical defence, physiological, and mechanical barriers. However, the effects of application of Si to the soil on plant defence through antioxidative enzymes and changes in the nutrient composition of soil and rice straw under climate change conditions remain unclear. Thus this study was aimed at investigating the effects of Si on plant defence and other biochemical changes in the brown planthopper (BPH), Nilaparvata lugens (Stål, 1854), soil and rice plants under elevated CO2 levels (570 ± 25 ppm) and elevated temperature (≃3°C higher than ambient) in open-top chambers (OTCs) during the rainy season of 2019 and 2020. The results revealed that under elevated CO2, Si amendment significantly enhanced the activity of defensive antioxidative enzymes, namely catalase (CAT), peroxidase (POD) and superoxide dismutase (SOD) upon BPH feeding in both plants and BPH, besides enhancing available forms of major nutrients, namely nitrogen (N), phosphorus (P), potassium (K), and minor nutrients, namely calcium (Ca), magnesium (Mg) and sulphur (S), and Si in soil and rice plants. The antioxidative enzymes’ mediated plant defence and positive alteration of the nutrient composition of soil along with other reported plant defences, namely callose deposition, silicification, and positive alteration of photosynthesis-related parameters, indicated Si amendment as a potential alternative strategy for BPH management under climate change conditions.
The Role of Ecumenism, Church, and Missiology in Violent Conflict from an African Postcolonial Theological Perspective
Authors: Nel Reginald W. 
Published: March 2024

Abstract
The defining sign of our time in relation to violent conflict is the ongoing Ukraine-Russia war. It impacts not only European countries, but also the Global South. From an African postcolonial theological perspective, the question is how to discern the ‘neutral’ stance of South Africa and various other African countries on Russia’s invasion of Ukraine? Therefore, this article aims to present a postcolonial African analysis of violent conflict and trauma in Africa. This will be done referring to the debate between Tinyiko Maluleke and Emmanuel Katongole on the future of African theology. It concludes that the churches in Africa and theology can play their role in a posture of humility, leading in performing rituals of lament in the face of trauma. The narrative of a future African theology (and African ecclesiology) may not adhere to Eurocentric (neocolonial) dictates, or to reductionist analysis of the context.
“Time for God’s Peace.” Approaching a Centennial in Dialogue with Pioneers in Ecumenical History
Authors: Gehlin Sara 
Published: March 2024

Abstract
This article explores how the pursuit of peace can inspire ecumenical theological discourses. Discussing the theme of the approaching Swedish Ecumenical Centennial in 2025, “Time for God’s Peace,” the article calls attention to voices of ecumenists who gathered in Sweden in the interwar and postwar periods, in the context of the Life and Work and the Faith and Order movements. By means of taking the endeavours of pioneers in ecumenical history into regard, the investigation focuses on how theology can be constructed with a peacebuilding purpose. Considering that the churches have not only played a peaceful role in face of conflict and war, the article entails exploring the role of self-critical introspection in such ecumenical theological work. Moreover, with regard to the future oriented nature of this work, the article pays particular attention to how it has engaged young ecumenists.
Prefiguration of the Nation: The Soteriology and Ecclesiology of the Iglesia Filipina Independiente in the Early 20th Century
Authors: Smit Peter-Ben 
Published: March 2024

Abstract
The Iglesia Filipina Independiente was established in 1902, in the context of the US occupation of the Philippines. The church has become known for its outspoken emancipatory political stance in the course of the 20th century. Yet, in its early days, the church wrestled with the question how to negotiate the restrictions that had been imposed regarding explicit political agitation. This paper argues that the church found a way forward regarding this by developing a prefigurative self-understanding, according to which the church, in its self-organization, theology and liturgy, foreshadowed the future of the nation of the Philippines as a whole. The ecclesiology of the church became its political program. Using insights from the study of prefigurative politics, it is shown how this course of action becomes evident in the Iglesia Filipina Independiente’s publications, such as journals and liturgical books.
Churches Facing War: Ecumenical Deadlocks and Ecclesiological Challenges
Authors: Keramidas Dimitrios 
Published: March 2024

Abstract
The war in Ukraine has generated a debate both within the orthodox church and on an inter-Christian level regarding the religious legitimation of military conflicts. The inability of inter-Orthodox and ecumenical bodies to formulate a common stance in the face of war has raised questions about the current methodology employed by ecumenical assemblies. Some have suggested exhausting the instruments of dialogue, while others have proposed expelling churches with a pro-war profile from ecumenical organisations. This article aims to demonstrate how this problem also arises from the politicisation of ecumenical assemblies, which detracts them from the ecclesiological principle that should guide Christian witness.
Enduring Ornaments
Authors: Gammel Irene 
Published: March 2024

Abstract
This article examines five found objects and assemblies created by Dada artist Baroness Elsa von Freytag-Loringhoven: Enduring Ornament (1913), Cathedral (c. 1918), Earring Object (1917–1919), Limbswish (1917–1919), and a now lost textile circle. These works, obscured for a long time, symbolize the historic silencing of Dada women. By merging feminist theories of performance, trash, and Dada, this article argues that the Baroness’s use of discarded materials generates radical destabilizations, infusing her work with affect, memory, and transatlantic connections to avant-garde artists. Drawing on new archival sources, the article situates the Baroness within the queered dynamics of The Little Review circle, revealing her interactions with figures such as Margaret Anderson, Jane Heap, and Allen C. Tanner, key figures of the queered avant-garde.
The Recollection of Revolution
Authors: Caradonna Chiara 
Published: March 2024

Abstract
The present article addresses issues related to the preservation of revolutionary memory, and to the role of acts of writing and reading in securing the continuity of the revolutionary impetus that brings about new beginnings. The role of memory is discussed through a comparison between two seminal texts on revolution that are not usually read together: Gustav Landauer’s Die Revolution (1907) and Hannah Arendt’s On Revolution (1963). It argues that both texts attempt to avoid the risk of reducing revolution to an object of historical inquiry and to keep the “spirit of revolution” alive by employing unconventional narrative techniques and ascribing a central role to literature.
Literature as Magic
Authors: Engel Amir 
Published: March 2024

Abstract
Magic and literature are mostly understood as mutually exclusive domains. Magic is taken to be part of religious life, an aspect of the human desire to overcome the order of things and strive for the supernatural. Literature, on the other hand, is commonly described as an artistic endeavor and thus associated with secular art and culture. For this reason, it is possible to read about magic in literature, but it is very rare to read literature as magic. This article aims to reverse that trend. It entails a contextual and critical discussion of Carl Einstein’s 1912 novel Bebuquin oder die Dilettanten des Wunders, suggesting that this novel is best understood as magic, that is, as a sincere and radical attempt to reach the supernatural and transform the present. The article also suggests that the avant-garde is precisely the context for a renewed appreciation of literature and religion.
Else Lasker-Schüler’s Mein Herz and the Circus Motif
Authors: Molad Adi Shoshana 
Published: March 2024

Abstract
This article explores the circus motif in German-Jewish Expressionist author and artist Else Lasker-Schüler’s 1912 novel Mein Herz: Ein Liebesroman mit Bildern und wirklich lebenden Menschen and in her 1937 prose collection Das Hebräerland. The article suggests that the presence of the circus is central to her avant-garde works and playful aesthetics and that the circus, belonging to the arena of childhood, reflects a longing for new beginnings. Exploring Lasker-Schüler’s imaginative yet serious approach to the circus and its cast of artists, its affinities to Lasker-Schüler’s Orientalism, and her use of various personas, the article investigates new beginnings as liberation revealed between Earth’s creatures and the cosmos.
Der Nister’s Soviet Surrealism
Authors: Caplan Marc 
Published: March 2024

Abstract
In the first half of his career, Der Nister (“the Hidden One,” Pinkhas Kaganovitsh, 1884–1950) created a sequence of densely allusive literary fairy tales, drawing from a cosmopolitan range of symbol systems to bypass prior Yiddish fiction’s focus on traditional Jewish life. Upon returning to the Soviet Union at the end of the 1920s, however, he saw that this avant-garde aesthetic had to be replaced with state-mandated Realist, proletarian fiction. The second phase in his writing begins with a sequence of travel writings, Hoyptshtet (“Capital Cities,” 1934). Here, realistic descriptions of Kharkiv, Leningrad, and Moscow blend with phantasmagoric digression. This combination of travel writing with fantasy calls upon a hybrid aesthetic analogous to Parisian Surrealism. Through this comparison, it becomes clear that Hoyptshtet is both Symbolist and Realist, Soviet and Surrealist.
Extracting Pseudo-Phocylides’ Maxims
Authors: La Barbera Paola Carmela 
Published: March 2024

Abstract
In this paper, I discuss the excerpts of the pseudo-Phocylidean Sententiae preserved in the gnomology transmitted by the manuscripts BAV, Vat. gr. 895 and Wien, Österreichisches Nationalbibliothek, Phil. gr. 169. My aim is to identify the sources from which the excerptor drew the ps.-Phocylidean maxims, as well as his working milieu. Moreover, I try to understand the relationship of this witness to the textual tradition of ps.-Phocylides and its stemma.
Gianfrancesco Corradino dall’Aglio and Two Manuscripts of Catullus That He Did Not Invent
Authors: Kiss Dániel 
Published: March 2024

Abstract
A new edition of the poems of Catullus was published in 1738 in Venice by a young scholar named Gianfrancesco Corradino dall’Aglio. The title and preface promised a revolutionary edition that would surpass all its predecessors and restore the authentic text of Catullus with the help of an excellent early manuscript discovered in Rome. Corradino dall’Aglio’s grandiose claims attracted criticism and he soon came to be accused of having invented his manuscript sources. This article shows that the accusations go back to a misunderstanding by Scipione Maffei, who accused the editor in 1749 of having invented a liber Maffei. In fact the references to that manuscript stem from Achilles Statius’ commentary of 1566. More recently, that manuscript has been identified by Berthold Ullman with BAV, Ott. lat. 1829, that is, the famous codex Romanus of Catullus. But from the late eighteenth century onwards, the accusations of fraud directed against Corradino dall’Aglio centered on the Roman manuscript that is mentioned in his title and preface. This article shows that that manuscript cannot be identified with any surviving manuscript of Catullus, but due to several factors there is no reason to believe that it was invented by Corradino dall’Aglio. The article closes with an examination of the editorial practice of the young scholar, who turns out to have been a conservative editor of Catullus: he often advocated the reading of the manuscripts against the conjectures of earlier editors.
Dahmān Āfrīn and Srōš: Analyzing a Connection
Authors: Raffaelli Enrico G. 
Published: March 2024

Abstract
This article investigates the theme, known from two passages of Pahlavi literature (Šāyist nē Šāyist 13.43 and Dēnkard 9.22.1), of the multiple comings of the deities Dahmān Āfrīn and Srōš to the world at night in order to give it increase. The article highlights that this theme reflects some characteristics of the Dahmā Āfriti prayer (which Dahmān Āfrīn personifies), and of the deity Sraoša (of whom Srōš is the equivalent) according to the Avestan tradition. Furthermore, the article highlights that this theme also reflects certain characteristics of the Dahmā Āfriti and of Srōš, as well as of the deity Dahmān Āfrīn, in the Zoroastrian tradition of the Sasanian to early Islamic times. The article analyzes these characteristics, and proposes some considerations on the relationship between Dahmān Āfrīn and Srōš. It also points out that a connection between Dahmān Āfrīn and Srōš is preserved in modern and contemporary Zoroastrian rituals.
nihang and āhang: Two Administrative Terms in Middle Persian and Bactrian
Authors: Saadat Yusef 
Published: March 2024

Abstract
Middle Persian nahang (historically preferable: nihang) is usually translated as ‘province’. The paper tries to demonstrate that the term most probably means ‘domain, orbit; region’. The two forms nihang and nahang also occur in Bactrian documents, translated by Sims-Williams as ‘adjacent’ and ‘environs’. Here it will be argued that this word is semantically narrowed down in Bactrian to a more technical term meaning ‘the land part of a property, simple land (not taking into account the accessories and facilities belonging to it)’. Furthermore, it is discussed that also the word āhang, which collocates with nihang in Bactrian documents, was a technical term, probably meaning ‘accessories and appurtenances; harvest, crop yield; usufruct (?).’ The same term is found in Pahlavi documents meaning “harvest, crop yield”.
From Historian to Poet: A Checklist of the Persian Poems of Idrīs Bidlīsī (Hašt Bihišt VI, Nuruosmaniye 3209)
Authors: Dehqan Mustafa 
Published: March 2024

Abstract
Many articles have been published on the life and career of Idrīs Bidlīsī (1457–1520) and his contribution to the history of Ottoman Empire. There has been much less research, especially in the West, into the influential role that Persian literature, especially Niẓāmī of Ganğa, played in all facets of his works. Consequently, even fewer studies have been done on Idrīs’ own poetry, which was composed mainly either in late fifteenth century, when he was still at the court of Aqquyunlu, or after his residence at the Ottoman court, especially in early sixteenth century. This study is dedicated to making a “voyage of discovery” of his Persian poems as reflected in the Book VI of Hašt Bihišt, an unpublished book of his magnum opus.
On Persian Design and Fashion in Twentieth-Century France: The 1930 Jean Pozzi Catalogue of Persian Art
Authors: Habibi Negar 
Published: March 2024

Abstract
This article examines the first catalogue of Jean Pozzi’s Persian collection, commented on and published by Edgar Blochet in 1930. Five of the nine coloured plates of the catalogue are from seventeenth-century Isfahan showing highly fashionable men and women wearing various outfits and headgear ornamented with different textile designs. Reviewing the keen Parisian interest in “Oriental” arts and crafts, and especially their appeal to renowned French couturiers and designers, we argue that Jean Pozzi’s catalogue may be seen as one of the persuasive Persian collections of the early twentieth century, providing the forms and tones that French industries of textile design and fashion sought before World War II.
Selection of a Surgical Approach for Middle Ear Cholesteatoma Based on the Fusion Images of Non-Echo Planar Diffusion-Weighted MRI and CT
Authors: Cao Maorong , Xu Tong , Jiang Wen , Chen Chengfang , Yang Huiming , Man Rongjun , Yu Shudong 
Published: March 2024

Purpose: This study aimed to explore the ability of fusion images of non-echo planar diffusion-weighted magnetic resonance imaging (non-EPI-DWI MRI) and computed tomography (CT) to accurately locate cholesteatoma and plan the surgical approach. Methods: In the first part, 41 patients were included. Their CT images and non-EPI DWMRI images were fused. The scope of cholesteatoma in the fusion image was compared with that in the surgical video to evaluate the capability to locate cholesteatoma. A total of 229 patients were included in the second part, and they were divided into 2 groups. We chose the surgical approach for the CT group and the fusion group, and compared the accuracy of surgical approaches in the CT group and the fusion group using the surgical records. Results: The location of cholesteatoma shown in the fusion images was almost identical to that observed during the operation (kappa = .862). The overall specificity and sensitivity of the fusion images in locating cholesteatoma were 94.12% and 93.06%, respectively. The accuracy of surgical approach selection based on the fusion images (99.02%) was higher than that of surgical approach selection based on the CT images (85.83%). Conclusion: It is recommended that the fusion images be used to locate the range of the cholesteatoma before operation.