bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gemcitabine, Cisplatin, and Radiotherapy for Patients With Locally Advanced Pancreatic Adenocarcinoma: Results of the North Central Cancer Treatment Group Phase II Study N9942
Authors: Haddock Michael G. , Swaminathan Revathi , Foster Nathan R. , Hauge Mark D. , Martenson James A. , Camoriano John K. , Stella Philip J. , Tenglin Richard C. , Schaefer Paul L. , Moore Dennis F. , Alberts Steven R. 
Published: June 2007

Purpose A phase II study was conducted to determine the efficacy and toxicity of radiotherapy with concomitant gemcitabine and cisplatin for patients with locally advanced pancreatic adenocarcinoma. Patients and Methods Forty-eight patients with locally advanced pancreatic adenocarcinoma received gemcitabine (30 mg/m2) and cisplatin (10 mg/m2) twice weekly during the first 3 weeks of radiotherapy. The radiation dose to the primary tumor and regional nodes was 45 Gy in 25 fractions, and the gross tumor volume received an additional 5.4 Gy in three fractions. Four weeks after radiotherapy, patients received gemcitabine (1,000 mg/m2) once weekly every 3 of 4 weeks for a 12-week period. The primary end point was survival at 12 months. Secondary end points were time to progression, toxicity, and quality of life. Results Survival at 1 year was 40% for 47 eligible patients. The median survival was 10.2 months. Confirmed responses were observed for 8.5% (two partial, two complete), and median time to progression was 7.3 months. Grade 4 or higher toxicity was observed for 31% and consisted primarily of hematologic and GI toxicity. There was a trend toward improved overall quality of life, measured by the Symptom Distress Scale (P = .06), with significant improvements in domains of insomnia, pain, and outlook. Conclusion The combination of radiotherapy, gemcitabine, and cisplatin was well tolerated. Survival results were similar to those achieved with other treatment regimens for patients with locally advanced pancreatic cancer but did not meet our predefined criteria for additional evaluation of this regimen.
Social and Racial Differences in Selection of Breast Cancer Adjuvant Chemotherapy Regimens
Authors: Griggs Jennifer J. , Culakova Eva , Sorbero Melony E.S. , Poniewierski Marek S. , Wolff Debra A. , Crawford Jeffrey , Dale David C. , Lyman Gary H. 
Published: June 2007

Purpose Breast cancer outcomes are worse among black women and women of lower socioeconomic status. The purpose of this study was to investigate racial and social differences in selection of breast cancer adjuvant chemotherapy regimens. Methods Detailed information on patient, disease, and treatment factors was collected prospectively on 957 patients who were receiving breast cancer adjuvant chemotherapy in 101 oncology practices throughout the United States. Adjuvant chemotherapy regimens included in any of several published guidelines were considered standard. Receipt of nonstandard regimens was examined according to clinical and nonclinical factors. Differences between groups were assessed using χ2 tests. Multivariate logistic regression was used to identify factors associated with use of nonstandard regimens. Results Black race (P = .008), lower educational attainment (P = .003), age ≥ 70 years (P = .001), higher stage (P < .0001), insurance type (P = .048), employment status (P = .045), employment type (P = .025), and geographic location (P = .021) were associated with the use of nonstandard regimens in univariate analyses. In multivariate analysis, black race (P = .020), lower educational attainment (P = .024), age ≥ 70 years (P = .032), and higher stage (P < .0001) were associated with receipt of nonstandard regimens. Conclusion The more frequent use of non–guideline-concordant adjuvant chemotherapy regimens in black women and women with lower educational attainment may contribute to less favorable outcomes in these populations. Addressing such differences in care may improve cancer outcomes in vulnerable populations.
High Expression Levels of the ETS-Related Gene, ERG, Predict Adverse Outcome and Improve Molecular Risk-Based Classification of Cytogenetically Normal Acute Myeloid Leukemia: A Cancer and Leukemia Group B Study
Authors: Marcucci Guido , Maharry Kati , Whitman Susan P. , Vukosavljevic Tamara , Paschka Peter , Langer Christian , Mrózek Krzysztof , Baldus Claudia D. , Carroll Andrew J. , Powell Bayard L. , Kolitz Jonathan E. , Larson Richard A. , Bloomfield Clara D. 
Published: June 2007

Purpose To validate ERG overexpression as an adverse predictor and assess its prognostic value in the context of other molecular markers in cytogenetically normal (CN) -acute myeloid leukemia (AML). Patients and Methods Seventy-six adult patients with primary CN-AML, younger than 60 years and treated on Cancer and Leukemia Group B (CALGB) trial 19808, were evaluated for ERG expression by quantitative reverse transcriptase polymerase chain reaction. They were then combined with 72 patients enrolled onto CALGB 9621 for analyses that included other molecular markers. Results Similar to patients enrolled onto CALGB 9621, high ERG expressers on CALGB 19808 had fewer complete remissions (CRs; P = .03) and worse event-free survival (EFS; P = .016) than low ERG expressers. In the combined set, high expressers (n = 55) had fewer CRs (P = .004) and shorter EFS (P < .001) than low expressers (n = 93). High ERG predicted failure to achieve CR (P = .004) after adjusting for BAALC expression (P = .04) and age (P = .008), and EFS (P = .004) after adjusting for FLT3 internal tandem duplication (ITD; P < .001). Among patients without FLT3-ITD (FLT3-ITD negative), only high ERG predicted shorter EFS (P = .001). Among NPM1-mutated (NPM1 positive) patients, high ERG predicted shorter EFS (P = .003), after adjusting for FLT3-ITD (P < .001). When all three markers were considered together, in the favorable FLT3-ITD–negative/NPM1-positive subset, high ERG was the only factor predicting shorter EFS (P = .002). Conclusion We validated ERG overexpression as an adverse predictor in CN-AML. Moreover, by using ERG expression levels, we improved the previously proposed molecular-risk classification of CN-AML based on the presence or absence of FLT3-ITD and NPM1 mutations, given that we identified subsets with different outcome among FLT3-ITD–negative, NPM1-positive, and FLT3-ITD–negative/NPM1-positive patients.
Identifying Stage III Colorectal Cancer Patients: The Influence of the Patient, Surgeon, and Pathologist
Authors: Morris Eva Judith Ann , Maughan Nicola Joanne , Forman David , Quirke Philip 
Published: June 2007

Purpose Nodal yields from resected colorectal cancers vary greatly. This study sought to determine what patient, tumor, and management factors influence the number of nodes retrieved and to determine if the extent of lymphadenectomy affects stage allocation and influences survival. Patients and Methods Retrospective study of the nodal yields of 7,062 surgically resected colorectal cancer patients for whom colorectal pathology minimum data sets had been collected. The percentage of patients diagnosed as stage III was compared across nodal yield categories. A threshold for an adequate lymphadenectomy was defined as retrieval of 12 nodes. Binary logistic regression was used to determine factors associated with obtaining an adequate lymphadenectomy. Results Median nodal yields increased over the study period from 7 (interquartile range [IQR], 4 to 11) in 1995 to 13 (IQR 8 to 19) in 2003. There was no difference in yield by cancer site or sex, but yields were lower in older patients. Yields increased with increasing local invasion and stage of tumor. The percentage of patients diagnosed as stage III increased as yields increased. Five-year survival was lower in those patients who did not have an adequate lymphadenectomy. Adequate lymphadenectomy was significantly more likely in patients with advanced tumors and when the surgery and pathology was undertaken by a specialist. Older patients were significantly less likely to receive an adequate lymphadenectomy. Conclusion Variations in nodal yield are due to idiosyncratic patient and tumor characteristics and differences in the quality of surgery and pathology undertaken. Adequate lymphadenectomy is essential to ensure correct stage allocation and optimal survival.
Weekly Infusional High-Dose Fluorouracil (HD-FU), HD-FU Plus Folinic Acid (HD-FU/FA), or HD-FU/FA Plus Biweekly Cisplatin in Advanced Gastric Cancer: Randomized Phase II Trial 40953 of the European Organisation for Research and Treatment of Cancer Gastrointestinal Group and the Arbeitsgemeinschaft Internistische Onkologie
Authors: Lutz Manfred P. , Wilke Hansjochen , Wagener D.J. Theo , Vanhoefer Udo , Jeziorski Krzysztof , Hegewisch-Becker Susanna , Balleisen Leopold , Joossens Eric , Jansen Rob L. , Debois Muriel , Bethe Ullrich , Praet Michel , Wils Jacques , Van Cutsem Eric 
Published: June 2007

Purpose This multicentric, randomized, two-stage phase II trial evaluated three simplified weekly infusional regimens of fluorouracil (FU) or FU plus folinic acid (FA) and cisplatin (Cis) with the aim to select a regimen for future phase III trials. Patients and Methods A total of 145 patients with advanced gastric cancer where randomly assigned to weekly FU 3,000 mg/m2/24 hours (HD-FU), FU 2,600 mg/m2/24 hours plus dl-FA 500 mg/m2 or l-FA 250 mg/m2 (HD-FU/FA), or FU 2000 mg/m2/24 hours plus FA plus biweekly Cis 50 mg/m2, each administered for 6 weeks with a 1-week rest. The primary end point was the response rate. Results Confirmed responses were observed in 6.1% (two of 33) of the eligible patients treated with HD-FU, in 25% (12 of 48, including one complete remission [CR]) with HD-FU/FA, and in 45.7% (21 of 46, including four CRs) with HD-FU/FA/Cis. The HD-FU arm was closed after stage 1 because the required minimum number of responses was not met. The median progression-free survival of all patients in the HD-FU, HD-FU/FA, and HD-FU/FA/Cis arm was 1.9, 4.0, and 6.1 months, respectively. The median overall survival was 7.1, 8.9, and 9.7 months, and the survival rate at 1 year was 24.3%, 30.3%, and 45.3%, respectively. Grade 4 toxicities were rare. The most relevant grade 3/4 toxicities were neutropenia in 1.9%, 5.4%, and 19.6%, and diarrhea in 2.7%, 1.9%, and 3.9% of the cycles in the HD-FU, HD-FU/FA, and HD-/FU/Cis arms, respectively. Conclusion Weekly infusional FU/FA plus biweekly Cis is effective and safe in patients with gastric cancer.
Hydrogen Production and Morphological Change of Chrysotile Asbestos in the Radiolysis of Aqueous Solutions
Authors: Aoyagi Noboru , Nagaishi Ryuji , Esaka Fumitaka , Yamada Reiji 
Published: June 2007

Abstract
A high yield of H2 gas was unprecedentedly produced by the radiolysis of water-containing asbestos while the morphology of them turned fibrous bundles into nonfibrous particles in 0.40 M H2SO4 solution over 2.0 MGy dose of irradiation.
A Dye-sensitized Solar Cell Using a Red Ruthenium(II) Complex with 9,9-Bis(4-methoxyphenyl)-4,5-diazafluorene
Authors: Ono Katsuhiko , Tanaka Hiromitsu , Shiozawa Masahito , Motohiro Tomoyoshi , Kunikane Shigemitsu , Saito Katsuhiro 
Published: June 2007

Abstract
A ruthenium(II) complex containing a 4,5-diazafluorene moiety as a polypyridyl ligand was synthesized and its properties were investigated. A solar cell using the complex as a dye sensitizer showed a solar energy-to-electricity conversion efficiency of η=7.3% under irradiation with AM 1.5 solar light; the value was slightly higher than that of red dye N719 (η=7.0%).
Novel Route to Synthesize Nanosized β-Zeolite with High Surface Area
Authors: Sakthivel Ayyamperumal , Komura Kenichi , Sugi Yoshihiro 
Published: June 2007

Abstract
Nanosized β-zeolite was synthesized in presence of two templates viz., tetraethylammonium hydroxide and cetyltrimethylammonium bromide by steaming dry-gel precursors.
Preparation of GaN Powder by Mechanochemical Treatment of Gallium under Ammonia Gas Environment
Authors: Kano Junya , Jenfeng Lu , Kang In-Cheol , Tongamp William , Kobayashi Eiko , Saito Fumio 
Published: June 2007

Abstract
A new route for synthesizing GaN from gallium metal by grinding in NH3 gas atmosphere is proposed in this paper. The proposed route is to grind Ga metal under ammonia gas atmosphere by using a planetary mill with unisized ZrO2 balls. The grinding, which induces mechanochemical reaction between the two, has been conducted. The formation of GaN was confirmed in XRD patterns, and the peak intensity of GaN increases with grinding time.
Anion Incorporation-induced Cage Deformation in 12CaO·7Al2O3 Crystal
Authors: Nomura Takatoshi , Hayashi Katsuro , Kubota Yoshiki , Kamiya Toshio , Hirano Masahiro , Takata Masaki , Hosono Hideo 
Published: June 2007

Abstract
Effects of O2− or OH− ion incorporation on the cage geometry in 12CaO·7Al2O3 (C12A7) crystals are examined by the maximum entropy method (MEM)/Rietveld analyses of synchrotron powder X-ray diffraction data. Presence of an extraframework anion in a cage causes inward displacements of two Ca2+ ions axially coordinating to the anion. The OH− ion locates at the cage center and induces smaller symmetric displacements of the two Ca2+ ions, while the O2− ion likely locates on off-axis positions and induces larger asymmetric Ca2+ ion displacements.
Measurements of Ammonium and Sodium salt Aerosol Particles Using a Laser-ionization Single-particle Aerosol Mass Spectrometer
Authors: Narukawa Masahiro , Matsumi Yutaka , Takahashi Kenshi , Yabushita Akihiro 
Published: June 2007

Abstract
Using a laser-ionization single-particle aerosol mass spectrometer (LISPA-MS), mass spectra of ammonium and sodium salt particles were obtained. In the negative-ion mass spectra, HSO4−, and NO2− and NO3− were dominant ions for (NH4)2SO4 and NH4NO3 particles, respectively, while ions with sodium were also dominant for Na2SO4 and NaNO3 particles. The chemical compositions of such salt aerosol particles can be inferred from the distribution of ions in those negative-ion mass spectra obtained using the LISPA-MS.
A Self-template Method for Mesoporous Organosilica Particles
Authors: Koo Sang Man , Hah Hoe Jin , Han Dong Il , Jung Chan Yoon 
Published: June 2007

Abstract
Mesoporous organosilica particles with large internal pores were prepared by a self-template, self-assembly process using homo- and heterocondensation of silane mixture, and extraction of highly soluble, homocondensed PTMS. This method not only provides a simple synthetic route without using an expensive template but also endows chemical flexibility to mesoporous particles owing to alkyl and aryl functional groups in organosilanes.
Complexant-assisted Fabrication of Flowery Assembly of Hexagonal Close-packed Cobalt Nanoplatelets
Authors: Ni Xiaomin , Li Dongguo , Zhang Yongfeng , Zheng Huagui 
Published: June 2007

Abstract
Flowery assembly of hexagonal close-packed (hcp) cobalt nanoplatelets was fabricated in high yield via a simple one-pot method without any surfactants. The process involved the reduction of the precursor of cobalt dimethylglyoximate with hydrazine in a basic medium. Thus-prepared cobalt flowers exhibited a ferromagnetic characteristic with the coercivity of 308 Oe at room temperature, much higher than that of bulk counterpart.
Renal transplantation in the rabbit: a model for preservation studies
Authors: Jacobsen I. A. 
Published: June 2007

Transplantation is necessary for evaluation of kidney preservation procedures, and a model using a small laboratory animal is desirable. The rabbit was found to be a suitable animal for this purpose. Even long periods of anaesthesia without artificial respiration were safely achieved. Hydration and serum electrolytes could be maintained within normal ranges with intravenous injections of isotonic saline and dextrose during and after the operation. The kidneys were implanted by anastomosing the artery and vein end-to-side to the abdominal aorta and the posterior vena cava respectively. The ureter was implanted into the bladder over a nylon stent. In a recent 100 transplantations the incidence of vascular thrombosis was low (4%), but rather more (10%) mainly late ureteral complications were encountered. Transplanted kidneys showed good function with mean peak serum creatinines of 285 μmol/l and normal macroscopic and histological appearance at autopsy.
Pox infection in white rats
Authors: Marennikova Svetlana S. , Shelukhina Emma M. , Fimina Valentina A. 
Published: June 2007

2 pox outbreaks among white rats in a breeding colony are described. The infection occurred in 3 different forms: pulmonary, dermal and mixed. Apparently healthy animals appeared to be virus carriers. The virus isolated belonged to the genus Orthopoxvirus of Poxviridae family, and was very close to cowpox virus. It differed from reference strains of cowpox virus in having a lower ceiling temperature and a higher pathogenicity for white rats.
Comparison of alkaline phosphatase and horseradish peroxidase conjugated antisera in the ELISA test for antibodies to reovirus 3, mouse hepatitis and Sendai viruses
Authors: Carthew P. , Gannon J. , Whisson I. 
Published: June 2007

The method of enzyme-linked immunoadsorbent assay (ELISA) has been applied to the detection of antibodies to reovirus 3, Sendai virus and mouse hepatitis virus (type 1), and the serological response of mice after infection has been followed for 28 days to investigate the earliest appearance of ELISA titres. This has been compared to the appearance of haemagglutination-inhibiting and complement-fixing antibodies. Alkaline phosphatase conjugated antiserum produces the most sensitive and convenient ELISA for the murine viruses examined.
Comparative feeding trials of 2 maintenance diets containing different crude protein levels
Authors: Connell Dorothea I. , Street W. , Pendry R. Ann , Yeboah J. , Godfrey A. 
Published: June 2007

2 commercially-produced maintenance diets containing crude protein levels of 14-15 and 21% were offered to normal mice and normal and thymectomized rats for 48-52 weeks. Both sexes of 2 strains of mouse, CBA/Ca and BALB/c, and 2 strains of rat, Wistar males and Lister Hooded females, were used, starting at 8-10 weeks of age. Results indicated that the diet containing 14-15% crude protein was an acceptable substitute for the 21% protein diet and could reduce the dietary cost by 30-40%.
The effect of diet on the incidence of pituitary tumours in female Wistar rats
Authors: Pickering R. G. , Pickering C. Elizabeth 
Published: June 2007

Each of 5 groups of 50 weanling Wistar-derived female rats was fed a different diet ad libitum for 2 years. The diets included 3 commercial maintenance diets (R and M No. 1, R and M No. 491 and RDM 22), a purified or semi-synthetic diet (LJ 80) and the diet (LAD 2) normally used in this laboratory. A weighed amount of LAD 2 diet (less than would be consumed under ad libitum conditions) was fed each day to a 6th group of rats. The survivals of the groups of rats fed either the standard diet (LAD 2) in restricted amount or the maintenance diet (RDM 22) were 62% and 66% respectively and were significantly better than the 40% survival of the group fed LAD 2 ad libitum. The survivals of the groups fed either Rand M No. 491 or LJ 80 were 40-42%, and the group fed Rand M No. 1 had a survival of 52%. At the end of 2 years the 2 groups with the best (>60%) survivals weighed significantly less than the group fed LAD 2 ad libitum. The groups fed either LAD 2 in restricted amount or RDM 22 had the least gross pathological lesions for the majority of the organs. These same groups also had fewer pituitary tumours per group (72% and 66%) than the group fed LAD 2 ad libitum (90%). The group fed RDM 22 also had the largest % (26%) of normal pituitaries of all the groups in the study. There were some significant differences between the haematological and clinical chemistry results of the group fed LAD 2 ad libitum and the other groups but none of the changes was considered adverse, although the groups fed either RDM 22 or Rand M No. 491 had significantly increased mean aminotransferase (AST and ALT) values with large variations which were adjudged undesirable. There was less protein in the urine of the groups fed either RDM 22 or LAD 2 (restricted).
Performance Bounds for Flexible Systems Requiring Setups
Authors: Singh Mahender P. , Srinivasan Mandyam M. 
Published: June 2007

Many organizations use product variety as one possible strategy for increasing their competitiveness. They have installed flexible manufacturing systems because these systems offer a powerful means for accommodating production and assembly of a variety of products. However, increased product variety comes at a cost. For instance, if the resource requires to be set up each time it switches to operate on a new product, the resulting delays and costs could negate the intended benefits of increased product variety. Analyzing these flexible resources for optimal design and operation is therefore very important. To address such issues, we model a flexible resource, serving multiple products, using a queueing model—more precisely, a polling model. In this model, a single server attends to multiple service centers (queues) at which requests arrive and queue up for service, performing a setup at a polled queue only if that queue is nonempty. This is the state dependent (SD) polling model. Exact analysis of the SD polling model is inherently very complex. This paper presents a very efficient procedure to compute a hierarchy of successively improving bounds on the values of performance measures obtained from the SD polling model with the exact solution as its limit. This procedure can be applied to quickly estimate performance measures for large SD polling models previously deemed analytically intractable.
Dense near octagons with four points on each line, II
Authors: De Bruyn Bart 
Published: June 2007

Abstract
This is the second paper in a series of three dealing with the classification of the dense near octagons of order (3, t). In [B. De Bruyn, Dense near octagons with four points on every line, I. Ann. Combin., to appear.], we determined all dense near octagons of order (3, t) with a big hex. In the present paper, we will obtain a partial classification of the valuations of the dense near hexagons of order (3, t). We shall use this classification to obtain some classification results regarding dense near polygons of order (3, t) containing exceptional hexes. The classification of the valuations will be used in [B. De Bruyn, Dense near octagons with four points on every line, III. Preprint.] to show that almost all dense near octagons of order (3, t) have a big hex.
On the Hermitian curvature of symplectic manifolds
Authors: Vezzoni Luigi 
Published: June 2007

Abstract
In this paper we give conditions for the integrability of almost complex structures calibrated by symplectic forms. We show that in the symplectic case the Newlander–Nirenberg theorem reduces to

and we give integrability conditions in terms of the curvature and the Hermitian curvature of the induced metric.
Compact Tits quadrangles as Lie geometries of topological Laguerre spaces
Authors: Margraf Marian , Rosehr Nils 
Published: June 2007

Abstract
We prove that the Lie geometry of a locally compact connected Laguerre space forms a compact connected generalized quadrangle. Moreover, if the geometric dimension of such a Laguerre space is at least three, this generalized quadrangle is isomorphic to a generalized quadrangle of Tits type; all compact connected generalized quadrangles of Tits type arise from Laguerre spaces.
On the roots of the Steiner polynomial of a 3-dimensional convex body
Authors: Hernández Cifre M. A , Saorín E 
Published: June 2007

Abstract
In this paper we study the geometric meaning of the roots of the Steiner polynomial in the 3-dimensional space. We give a complete characterization of the convex bodies in ℝ3 depending on the type of roots of their Steiner polynomials. Furthermore, we show that these roots are also related to the famous Blaschke problem and the Teissier conjecture.