bluuebunny/crossref_metadata_2025_split huggingface dataset:
Construction of CDKN2A-related competitive endogenous RNA network and identification of GAS5 as a prognostic indicator for hepatocellular carcinoma
Authors: Pan Yong , Zhang Yi-Ru , Wang Ling-Yun , Wu Li-Na , Ma Ying-Qiu , Fang Zhou , Li Shi-Bo 
Published: April 2024

BACKGROUND
Competitive endogenous RNA (ceRNA) is an innovative way of gene expression modulation, which plays a crucial part in neoplasia. However, the intricacy and behavioral characteristics of the ceRNA network in hepatocellular carcinoma (HCC) remain dismal.
AIM
To establish a cyclin dependent kinase inhibitor 2A (CDKN2A)-related ceRNA network and recognize potential prognostic indicators for HCC.
METHODS
The mutation landscape of CDKN2A in HCC was first explored using the cBioPortal database. Differential expression analysis was implemented between CDKN2Ahigh and CDKN2Alow expression HCC samples. The targeted microRNAs were predicted by lncBasev3.0, and the targeted mRNAs were predicted by miRDB, and Targetscan database. The univariate and multivariate analysis were utilized to identify independent prognostic indicators.
RESULTS
CDKN2A was frequently mutated and deleted in HCC. The single-cell RNA-sequencing analysis revealed that CDKN2A participated in cell cycle pathways. The CDKN2A-related ceRNA network-growth arrest specific 5 (GAS5)/miR-25-3p/SRY-box transcription factor 11 (SOX11) was successfully established. GAS5 was recognized as an independent prognostic biomarker, whose overexpression was correlated with a poor prognosis in HCC patients. The association between GAS5 expression and methylation, immune infiltration was explored. Besides, traditional Chinese medicine effective components targeting GAS5 were obtained.
CONCLUSION
This CDKN2A-related ceRNA network provides innovative insights into the molecular mechanism of HCC formation and progression. Moreover, GAS5 might be a significant prognostic biomarker and therapeutic target in HCC.
Risk factors for hepatocellular carcinoma associated with hepatitis C genotype 3 infection: A systematic review
Authors: Farooq Hamzah Z , James Michael , Abbott Jane , Oyibo Patrick , Divall Pip , Choudhry Naheed , Foster Graham R 
Published: April 2024

BACKGROUND
Hepatitis C virus (HCV) is a blood-borne virus which globally affects around 79 million people and is associated with high morbidity and mortality. Chronic infection leads to cirrhosis in a large proportion of patients and often causes hepatocellular carcinoma (HCC) in people with cirrhosis. Of the 6 HCV genotypes (G1-G6), genotype-3 accounts for 17.9% of infections. HCV genotype-3 responds least well to directly-acting antivirals and patients with genotype-3 infection are at increased risk of HCC even if they do not have cirrhosis.
AIM
To systematically review and critically appraise all risk factors for HCC secondary to HCV-G3 in all settings. Consequently, we studied possible risk factors for HCC due to HCV-G3 in the literature from 1946 to 2023.
METHODS
This systematic review aimed to synthesise existing and published studies of risk factors for HCC secondary to HCV genotype-3 and evaluate their strengths and limitations. We searched Web of Science, Medline, EMBASE, and CENTRAL for publications reporting risk factors for HCC due to HCV genotype-3 in all settings, 1946-2023.
RESULTS
Four thousand one hundred and forty-four records were identified from the four databases with 260 records removed as duplicates. Three thousand eight hundred and eighty-four records were screened with 3514 excluded. Three hundred and seventy-one full-texts were assessed for eligibility with seven studies included for analysis. Of the seven studies, three studies were retrospective case-control trials, two retrospective cohort studies, one a prospective cohort study and one a cross-sectional study design. All were based in hospital settings with four in Pakistan, two in South Korea and one in the United States. The total number of participants were 9621 of which 167 developed HCC (1.7%). All seven studies found cirrhosis to be a risk factor for HCC secondary to HCV genotype-3 followed by higher age (five-studies), with two studies each showing male sex, high alpha feto-protein, directly-acting antivirals treatment and achievement of sustained virologic response as risk factors for developing HCC.
CONCLUSION
Although, studies have shown that HCV genotype-3 infection is an independent risk factor for end-stage liver disease, HCC, and liver-related death, there is a lack of evidence for specific risk factors for HCC secondary to HCV genotype-3. Only cirrhosis and age have demonstrated an association; however, the number of studies is very small, and more research is required to investigate risk factors for HCC secondary to HCV genotype-3.
Pathologically successful conversion hepatectomy for advanced giant hepatocellular carcinoma after multidisciplinary therapy: A case report and review of literature
Authors: Chu Ju-Hang , Huang Lu-Yao , Wang Ya-Ru , Li Jun , Han Shi-Long , Xi Hao , Gao Wen-Xue , Cui Ying-Yu , Qian Ming-Ping 
Published: April 2024

BACKGROUND
Hepatocellular carcinoma (HCC) is one of the leading causes of death due to its complexity, heterogeneity, rapid metastasis and easy recurrence after surgical resection. We demonstrated that combination therapy with transcatheter arterial chemoembolization (TACE), hepatic arterial infusion chemotherapy (HAIC), Epclusa, Lenvatinib and Sintilimab is useful for patients with advanced HCC.
CASE SUMMARY
A 69-year-old man who was infected with hepatitis C virus (HCV) 30 years previously was admitted to the hospital with abdominal pain. Enhanced computed tomography (CT) revealed a low-density mass in the right lobe of the liver, with a volume of 12.9 cm × 9.4 cm × 15 cm, and the mass exhibited a “fast-in/fast-out” pattern, with extensive filling defect areas in the right branch of the portal vein and an alpha-fetoprotein level as high as 657 ng/mL. Therefore, he was judged to have advanced HCC. During treatment, the patient received three months of Epclusa, three TACE treatments, two HAIC treatments, three courses of sintilimab, and twenty-one months of lenvatinib. In the third month of treatment, the patient developed severe side effects and had to stop immunotherapy, and the Lenvatinib dose had to be halved. Postoperative pathological diagnosis indicated a complete response. The patient recovered well after the operation, and no tumor recurrence was found.
CONCLUSION
Multidisciplinary conversion therapy for advanced enormous HCC caused by HCV infection has a significant effect. Individualized drug adjustments should be made during any treatment according to the patient's tolerance to treatment.
Primary pancreatic peripheral T-cell lymphoma: A case report
Authors: Bai Yan-Liang , Wang Li-Jie , Luo Hui , Cui Ya-Bin , Xu Jin-Hui , Nan Hui-Jie , Yang Pei-Yao , Niu Jun-Wei , Shi Ming-Yue 
Published: April 2024

BACKGROUND
Primary pancreatic lymphoma (PPL) is an exceedingly rare tumor with limited mention in scientific literature. The clinical manifestations of PPL are often nonspecific, making it challenging to distinguish this disease from other pancreatic-related diseases. Chemotherapy remains the primary treatment for these individuals.
CASE SUMMARY
In this case study, we present the clinical details of a 62-year-old woman who initially presented with vomiting, abdominal pain, and dorsal pain. On further evaluation through positron emission tomography-computed tomography, the patient was considered to have a pancreatic head mass. However, subsequent endoscopic ultrasonography-guided fine needle aspiration (EUS-FNA) revealed that the patient had pancreatic peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS). There was a substantial decrease in the size of the pancreatic mass after the patient underwent a cycle of chemotherapy comprised of brentuximab vedotin, decitabine, and oxaliplatin (brentuximab vedotin and Gemox). The patient had significant improvement in radiological findings at the end of the first cycle.
CONCLUSION
Primary pancreatic PTCL-NOS is a malignant and heterogeneous lymphoma, in which the clinical manifestations are often nonspecific. It is difficult to diagnose, and the prognosis is poor. Imaging can only be used for auxiliary diagnosis of other diseases. With the help of immunostaining, EUS-FNA could be used to aid in the diagnosis of PPL. After a clear diagnosis, chemotherapy is still the first-line treatment for such patients, and surgical resection is not recommended. A large number of recent studies have shown that the CD30 antibody drug has potential as a therapy for several types of lymphoma. However, identifying new CD30-targeted therapies for different types of lymphoma is urgently needed. In the future, further research on antitumor therapy should be carried out to improve the survival prognosis of such patients.
The 2023 Dengue Outbreak in Bangladesh: Exploring the Epidemiology in Hospitalized Patients
Authors: Anika Urby Saraf , Islam Muna , Mou Fatema E Nur , Saha Mrinal , Deb Aparna , Tui Rubaiya Rahman , Manzoor Joarder Rakeen , Jesmin Afroza , Martuja Ayesha , Fardous Jannatul , Sharif Mohiuddin , Rafi Md. Abdur , Hasan Mohammad Jahid 
Published: April 2024

ABSTRACT.
For the past two decades, Bangladesh has faced recurrent dengue outbreaks, with the most recent occurring in 2023. We investigated the socioeconomic, clinical, and laboratory aspects of patients diagnosed with dengue during this outbreak. This observational study was conducted from July to September 2023 at Dhaka Medical College Hospital and Chittagong Medical College Hospital, and included 450 confirmed cases of dengue. Sociodemographic information was collected via face-to-face interviews, clinical examinations, and laboratory testing, which was done within 24 hours of admission. Dengue severity was classified according to the 2009 WHO dengue guidelines. Notably, 17% of patients experienced severe dengue, and 89% of those with nonsevere cases exhibited at least one warning sign. Most patients were young adults (mean age, 33 years), with a nearly equal male-to-female ratio. Common clinical presentations included fever (95%), myalgia (62%), and headache (58%), whereas warning signs such as vomiting (54%) and abdominal pain (39%) were prevalent. Plasma leakage indicators, including ascites, pleural effusion, and edema, were found predominantly in severe cases. Laboratory findings revealed leukopenia, thrombocytopenia, and elevated hepatic enzymes (alanine aminotransferase and aspartate aminotransferase) in nearly half the patients. An elevated hematocrit level was associated with severe dengue. We report that a substantial number of patients developed severe dengue during the epidemic in 2023, and provide detailed clinical–epidemiological profiles of the patients, offering valuable insight into management of dengue cases.
Прогностичне оцінювання ефективності розробленої функціонально-організаційної моделі збереження здоров’я та професійної працездатності військовослужбовців у воєнний та мирний (повоєнний) час
Authors: Tkalenko О. М. 
Published: April 2024

Мета дослідження. Узагальнити результати незалежної експертної оцінки прогностичної ефективності обґрунтованої, розробленої та впровадженої за більшістю компонентів функціонально-організаційної моделі збереження здоров’я та професійної працездатності військовослужбовців у воєнний та в мирний (повоєнний) час.
Матеріали та методи дослідження. Експертна група включала 22 висококваліфікованих фахівців у сфері військової охорони здоров’я. Експертне оцінювання проводилось шляхом заповнення спеціально розробленої анкети, з використанням п’ятибальної оціночної шкали елементів моделі, з дотриманням принципу анонімності експерта. Отримані від експертів анкети підлягали обробці та аналізу по кожному складовому елементу системи, який оцінювався. Підраховувались середньоарифметичні значення оцінок в балах, середньоквадратичні відхилення, стандартна похибка середньої величини та коефіцієнт варіації.
Результати дослідження. За результатами незалежної експертної оцінки встановлено високу прогностичну ефективність запропонованій моделі за кожним представленим до розгляду критерієм: орієнтованість на підвищення якості медичної допомоги військовослужбовцям – 4,1±0,11; впровадження стандартів НАТО – 4,0±0,12; спрямованість на вчасне виявлення та лікування розладів психіки у комбатантів – 4,2±0,15; орієнтованість на покращення поінформованості та залученню військовослужбовців до відповідального ставлення до здоров’я – 4,3±0,15; спрямованість на удосконалення післядипломної освіти військових лікарів – 4,4±0,17; забезпечення раціонального використання ресурсів – 3,7±0,17.
Висновки. Узгоджена оцінка залучених експертів щодо прогностичної ефективності розробленої та впровадженої за більшістю компонентів функціонально-організаційної моделі збереження здоров’я та професійної працездатності військовослужбовців у воєнний та в мирний (повоєнний) час обґрунтовує доцільність її практичного використання.
Нові похідні 1,2,4-Триазолу як протигрибкові агенти (огляд літератури)
Authors: Prytula R. L. , Shmatenko O. P. , Bushueva I. V. , Parchenko V. V. , Yerenko O. K. , Drozdov D. V. 
Published: April 2024

Метою нашого дослідження було систематизувати дані наукової літератури про протигрибкову активність похідних 1,2,4-триазолу та, на основі системного аналізу наукових джерел, визначити найперспективніший напрямок для подальших наукових досліджень.
Матеріали і методи дослідження. Було проведено інформаційний пошук наукових джерел, що описують протигрибкову активність похідних 1,2,4-триазолу, аналіз даних наукових джерел для визначення спектра протигрибкової дії похідних 1,2,4-триазолу, їх механізмів дії, а також сфери їх застосування, застосовано бібліосемантичний метод (вивчення та аналіз термінології, понять та категорій, що використовуються в науковій літературі для опису протигрибкової активності похідних 1,2,4-триазолу), системний метод (дослідження протигрибкової активності похідних 1,2,4-триазолу як цілісної системи, з урахуванням взаємозв'язків між різними її елементами), описовий метод (опис та систематизація даних про протигрибкову активність похідних 1,2,4-триазолу), та проведено узагальнення результатів дослідження та формулювання висновків. У якості матеріалів дослідження було використано наукові статті, монографії, патенти, дисертації, що містять інформацію про протигрибкову активність похідних 1,2,4-триазолу та сфери їх застосування.
Висновки. Похідні 1,2,4-триазолу є перспективним класом протигрибкових сполук. Подальші дослідження в цій галузі можуть призвести до розробки нових ефективних протигрибкових препаратів. Токсичність, резистентність до ліків і випадкова відсутність бажаної ефективності ліків викликають нагальну потребу в дослідженні та розробці нових протигрибкових ліків. Відповідно, проведений аналіз літературних джерел може надати наступні стратегії щодо розширення сфери застосування «хімічних каркасів» як протигрибкових засобів: розробка нових хімічних речовин для селективної грибкової мішені.. Перепрофілювання доступних препаратів як протигрибкових засобів. Комбінована терапія. Розробка гібридних протигрибкових агентів, що вражають дві або більше грибкових мішеней.
Foundation Treatment, Reinforcement and Design Optimization for Oil Storage Tanks at TAZAMA Pipelines Limited (Ndola, Copperbelt Province, Zambia)
Authors: Lupunga Mwansa Andrew , Huang Liang , Li Haotian 
Published: April 2024

Addressing foundation soil consolidation and subsoil treatment/reinforcement pertaining to oil storage tanks is essential for ensuring their long-term structural stability and minimizing risks associated with ground movement. This study will specifically revolve around investigating Foundation Treatment, Reinforcement and Design Optimization for Oil Storage Tanks at TAZAMA Pipelines Limited Ndola Site, (a key player in the transportation of petroleum products between Zambia and Tanzania). Key content of article: - Through systematic analysis of survey data of the target area, the engineering characteristics and distribution patterns of soft soil foundations in site area was analysed and appropriate foundation treatment and reinforcement methods of oil storage tanks within the area was taken into consideration.- Demonstrated significance of applying chosen method of optimization to address the soil consolidation issues; i.e. presented through level for level analysis of application model.- Considered a 50,000m3 floating roof oil storage tank foundation for soil consolidation optimization, analysing practicality and feasibility of study.The main author of this article served as a Civil Engineering Intern at TAZAMA Pipelines Limited.
impacto das fake news nas eleições presidenciais de 2018 e 2022
Authors: Curi Junior Aribelco , Alfaya Natalia Maria Ventura da Silva 
Published: April 2024

Este artigo destaca o crescente debate em torno dos limites da liberdade de expressão, que se intensificou nos últimos anos. Examina-se como esse princípio jurídico fundamental tem sido distorcido, especialmente por grupos extremistas, entre os quais se destaca o "gabinete do ódio". Além disso, oferece uma análise detalhada das principais fake news disseminadas durante as últimas eleições presidenciais por esses grupos. Ao examinar essas informações falsas, busca-se compreender como tais práticas influenciaram o processo eleitoral, destacando a importância de enfrentar os desafios associados à desinformação e preservar a integridade do sistema democrático. Destaca-se a relevância desse debate no contexto atual, considerando os impactos dessas distorções no panorama político e social.
Análisis biomecánico de la voz y percepción de la capacidad vocal como herramientas para la detección de dificultades vocales en el alumnado y profesorado universitario y de interpretación vocal
Authors: García Escudero Fernando , Gutiérrez Fonseca Raimundo , Rodríguez Caravaca Gil , Fernández-Baillo y Rodríguez de Sacristana Roberto , González Díaz Alba , Durán Poveda Manuel 
Published: April 2024

La demanda comunicativa oral aumenta diariamente en el ejercicio de funciones laborales en las que la voz es necesaria para el desempeño del trabajo diario. Profesores, cantantes, actores, teleoperadores, comunicadores, taquilleros, sanitarios, entre otras profesiones, se encuentran sometidos a una carga vocal muy elevada ya que utilizan su voz en alta intensidad durante amplios periodos de tiempo, presentando una mayor predisposición e incidencia de desarrollar patología vocal.
El objetivo del presente estudio es analizar las diferencias en cuanto a dificultades vocales entre un grupo de Educación Artística (GE-A) y un grupo de Educación no Artística (GE-NA) mediante un procedimiento de cribado basado del análisis biomecánico de la voz junto con el cuestionario discapacidad vocal del VHI-10.
La hipótesis sugiere que los integrantes del grupo GE-A presentan mayor grado de alteración funcional que el GE-NA motivado por la sobrecarga diaria que genera la alta demanda vocal propia de la especialidad.
Se recogieron muestras de 182 participantes, 80 hombres y 102 mujeres. Los datos del cribado por análisis biomecánico de las cuerdas vocales revelan un perfil con mayor desequilibrio en la dinámica de los pliegues vocales durante la fonación en el GE-A. Estos resultados podrían estar asociados a una mayor demanda vocal en los GE-A y justificaría implementar medidas periódicas de diagnóstico y prevención, así como tratamientos específicos de rehabilitación logopédica en el presente grupo.
Breaking the Silence: A Quantitative Analysis of Challenges among Orphaned Children in Sargodha District Orphanages
Authors: Asif Rashna , Gilani Tahira , Iqbal Mateen , Imran Muhammad 
Published: April 2024

Orphans represent a significant population worldwide, and orphan homes are responsible for providing support for holistic development in the lives of children. The purpose of the study was to investigate the psychological, social, and educational challenges faced by orphan children in orphan homes. The theoretical framework of the current study was based on the Attachment Theory by Bowlby, which states how early caregiver relationships influence the psychological, social, and educational development of orphan children in orphan homes. All of the orphan children in SOS Children Village district Sargodha made up the population of the current study. A sample of 206 orphan children was selected randomly from SOS Children Village district Sargodha. Reliable data were gathered using a quantitative survey study design, and the instrument's reliability was confirmed by Cronbach's Alpha, which was found to be 0.89. The obtained data were analyzed using descriptive statistics such as mean, standard deviations, frequency percentages, and inferential statistics, for instance, the t-test. The results showed that gender was found to be significant regarding psychological, social, and educational challenges. In addition, female orphan children have a greater mean score as compared to males concerning psychological and social challenges. While, concerning educational challenges male orphans have a greater mean score as compared to female orphan children. However, to overcome these challenges it is suggested that it is essential to create efficient programs that can recognize and tackle the emotional, social, and academic difficulties orphaned children confront.
Expansion analysis of urban microdrainage in Sergipe cities
Authors: Santos Neris Carolaine , Cristine Gomes de Araujo Laline , Caetano Vieira Zacarias 
Published: April 2024

We aim to explore the criteria surrounding urban microdrainage, as well as analyze its expansion in the state of Sergipe. The investigation was carried out based on data made available by the National Sanitation Information System (SINIS), using the years 2017 to 2021 as a reference. The growth in the number of public roads and data on variations in the number of gutter inlets will be analyzed in each of the 75 municipalities in Sergipe. To survey and analyze the development in each municipality of Sergipe, EXCEL was used to organize the data and create graphs for analysis.
P.E. OSTROVSKIKH'S ETHNOGRAPHIC STUDIES OF THE KHAKASS IN 1894
Authors: Чертыков В.К. 
Published: April 2024

Студент Санкт-Петербургского университета П. Е. Островских летом 1894 г. по заданию Академии наук занимался сбором этнографических предметов и древностей у хакасов - коренного населения Минусинского округа Енисейской губернии. Исследования он проводил в основном на территории Абаканской инородной управы, и частично - в Сагайской Степной думе. Результаты его работы нашли отражение в статье «Этнографические заметки о тюрках Минусинского края». В статье дается анализ результатов исследования П. Е. Островских.
In the summer of 1894, a student of Saint Petersburg University,on the assignment of the Academy of Sciences, P. E. Ostrovskikh was engaged in collecting ethnographic objects and antiquities from the Khakass - the indigenous population of the Minusinsk Region of the Yenisei Governorate. He conducted research mainly on the territory of the Abakan Indigenous Council, and partly in the Sagai Steppe Duma. The results of his work are reflected in the article «Ethnographic notes on the Turks of the Minusinsk Region». The article analyzes the results of P.E. Ostrovskikh's research.
COLLECTIVIZATION IN BURYATIA: SEARCH FOR AN EFFECTIVE FORM
Authors: Маншеев Д.М. 
Published: April 2024

В статье на основе известных и новых опубликованных архивных источников по истории коллективизации в Бурятии проведена попытка выявления компонентов процесса поиска эффективной модели организации сельского хозяйства в СССР. Исследование показало, что работающая модель коллективного хозяйства в виде сельскохозяйственных артелей была сформирована большевиками за короткий срок на практике путем проб и ошибок.
Based on known and new published archival sources on the history of collectivization in Buryatia, the article made an attempt to identify the components of the process of searching for an effective model of organizing agriculture in the USSR. The study showed that the working model of collective farming in the form of agricultural artels was formed by the Bolsheviks within a short time in practice by trial and error.