bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dioxo‐2,5 pipérazines. 1. La synthèse des carboxythiazolo dioxo‐2,5 pipérazines
Authors: Jerumanis Stanislas , Lemieux Alain 
Published: March 2009

AbstractLine route nouvelle et générale pour préparer les carboxythiazolo dioxo‐2,5 pipérazines est decrite. Dansles reactions de formation du cycle de la dioxo‐2,5 pipérazine, la Néthoxycarbonyle éthoxy‐2 dihydro‐1,2 quinoléine (EEDQ) a été utilisée comme agent d'activation. Par cette méthode le butoxycarbonyl‐9 diméthyl‐7,7 dioxo‐2,5 thia‐8 diaza‐1,4 bicyclo[4,3,0]nonane (6) et le car‐boxy‐9 dimèthyl‐8,8 dioxo‐2,5 thia‐7 diaza‐1,4 bicyclo[4,3,0]nonane (8)ont été obtenus, avec un rendement quasi quantitatif, en utilisant la carboxy‐4 butoxycarbonyl‐2 diméthyl‐5,5 thiazolidine (4) comme produit de départ. L'ester 6 a été hydrolysé avec de l'hydroxyde de barium en acide correspondant 7 et l'acide 8 traité avec du diazométhane a donné l'ester 9. L'ester 6 a été synthé‐tisé aussi à partir de l'ester éthylique de la N‐(butoxycarbonyl‐2 carboxy‐4 diméthyl‐5,5 thiazoli‐dine)glycine (10). Les données spectroscopiques sont interprétées pour confirmer les structures de nouveaux produits obtenus.
The synthesis of 11H‐1,2,4‐triazolo[4,3‐b]pyridazino[4,5‐b]indoles,11H‐tetrazolo[4,5‐b]pyridazino[4,5‐b]indoles and 1,2,4‐triazolo[3,4‐f]‐1,2,4‐triazino[4,5‐a]indoles
Authors: Monge Vega A. , Aldana I. , Rabbani M. M. , Fernandez‐Alvarez E. 
Published: March 2009

AbstractThis paper describes the synthesis of the previously unknown 11H‐1,2,4‐triazolo[4,3‐b]pyridazino[4,5‐b]indoles (2) and 11H‐tetrazolo[4,5‐b]pyridazino[4,5‐b]indoles (3) from 4‐hydrazino‐5H‐pyridazino[4,5‐b]indoles (1), as well as the synthesis of 1,2,4‐triazolo[3,4‐f]‐1,2,4‐triazino‐[4,5‐a]indoles (10) from 2‐indolecarbohydrazide (4). Compounds 2 were obtained by acylation of compounds 1, followed of thermal cyclization and compounds 3 by treating compounds 1 with nitrous acid. The reactions of compound 4 with formic acid or ethyl orthoformiate gave 1,2‐dihydro‐1‐oxo‐1,2,4‐triazino[4,5‐a]indole (6). Treating this last compound with phosphorus oxychloride or phosphorus pentasulfide, followed by hydrazine, gave 1‐hydrazino‐1,2,4‐triazino‐[4,5‐a]indole (9). Acylation of this last compound, followed of cyclization gave compounds 10. All the compounds were characterized by elemental analysis and ir and 1H‐nmr spectra.
Studies on sulphur heterocycles. Reactions of 6,7‐dihydrobenzo[b]thiophen‐4(5H)one derivatives and their conversion to 7‐substituted thieno[2,3‐h][1]benzopyran‐8‐ones
Authors: Asprou Chris M. , Brunskill John S. A. , Jeffrey Howard , De Asish 
Published: March 2009

AbstractCyclization of γ‐(2‐thienyl)butryic acid with acid anhydrides gives 2‐acyl derivatives as well as the expected 6,7‐dihydrobenzo[b]thiophen‐4(5H)one. Several reactions of these ketones have been studied including their conversion to 0,0‐diethyl thiophosphonohydrazones. 7‐Substituted thieno[2,3‐h][1]benzopyran‐8‐ones have been prepared via 4‐hydroxybenzo[b]thiophen‐5‐carbaldehydes.
New heterocyclic ring systems from α‐hydroxymethyleneketones. X Thiadiazasteroid‐related compounds
Authors: Brunelli Carlo , Fravolini Arnaldo , Grandolini Giuliano , Cristina Tiralti M. 
Published: March 2009

AbstractSome thiadiazasteroid analogues have been synthesized by the reaction of 3‐hydroxymethyl‐enebenzo[h]thiochroman‐4‐one with hydrazine and substituted hydrazines, semicarbazide and thiosemicarbazide. Pmr data supporting the structural assignments have been discussed.
On the reaction of methoxide ion with bromoiodothiophenes
Authors: Gronowitz Salo , Hallberg Anders , Glennow Christer 
Published: March 2009

AbstractThe reaction of 3‐bromo‐2‐iodothiophene with sodium methoxide in methanol, pyridine or hexamethylphosphoric triamide and the same reaction of 4‐bromo‐2‐iodo‐ and 4‐bromo‐3‐iodo‐thiophene in pyridine led to a halogen‐dance, giving the same mixture of 3‐bromothiophene, bromo‐iodothiophenes, diiodo‐bromothiophenes and triiodo‐bromothiophenes. The reaction of all three isomeric bromo‐iodothiophenes with sodium methoxide in methanol in the presence of cupric oxide gave 4‐bromo‐2‐methoxythiophene.
Hydrolytic cleavages of 7‐nitro‐2‐phenyl‐1,2‐benzisoxazol‐3‐one. Evidence for the occurrence of a benzidine‐like rearrangement of N,O‐diphenylhydroxylamines
Authors: Sheradsky Tuvia , Avramovici‐Grisaru Schely 
Published: March 2009

AbstractPreparation of the title compound 1 is described. Its treatment with base caused hydrolysis of the amide bond and subsequent benzidine‐like rearrangement to give 4′‐amino‐3‐carboxy‐4‐hydroxy‐5‐nitrobiphenyl (4). Acid treatment caused cleavage of the nitrogen‐oxygen bond and rearrangement to 7‐nitro‐3‐phenylbenzoxazol‐2‐one (6).
Sels d'aziridinium stables C‐fonctionnalisés III: Synthèse et caractérisation d'aziridines protonées épimères à l'azote
Authors: Baret Par Paul , Rivoirard Eve‐Marie , Pierre Jean‐Louis 
Published: March 2009

AbstractLe traitement d'aziridines C‐fonctionnalisées par l'acide fluorosulfurique permet la préparation des sels d'aziridinium N‐protonés correspondants avec des rendements élevés. L'action du fluorosulfate de méthyle sur les aziridines secondaires conduit également aux sels d'aziridinium N‐protonés. Les sels protonés sont isolés et caractérisés par voies chimique et spectroscopique. La configuration des épimères à l'azote est établie par effet Overhauser nucléaire et la stéreéchimie de la réaction est discutée.
Syntheses of fluorescent dyes. IX. New 4‐hydroxycoumarins, 4‐hydroxy‐2‐quinolones, 2H,5H‐Pyrano[3,2‐c]benzopyran‐2,5‐diones and 2H,5H‐Pyrano[3,2‐c]quinoline‐2,5‐diones
Authors: Knierzinger Andreas , Wolfbeis Otto S. 
Published: March 2009

Abstract7‐Substituted 4‐hydroxycoumarins (2a‐e) and 4‐hydroxy‐2‐quinolones (2f‐i) have been synthesized from the appropriate phenols or anilines and were converted to the enamines 3 using triethoxymethane and aniline. Condensation of 3 with nitriles 4a‐h gave substituted 2H,5H‐pyrano[3,2‐c]benzopyran‐2,5‐diones (5a‐r) or 2H,5H‐pyrano[3,2‐c]quinoline‐2,5‐diones (5s‐x), which exhibit both spontaneous and stimulated fluorescence with maxima between 418 and 549 nm. The marked influence of an electron withdrawing 3‐substituent in 5 is demonstrated by the fluorescence spectra of 7a,b (synthesized from 2d,e and ethyl 3‐oxobutyrate), whose maxima are sharply shifted to the blue as compared with compounds 21‐r.
A reinvestigation of the stevens rearrangement of 1,3,4‐trimethyl‐1‐(3,4,5‐trimethoxybenzyl)‐1,2,5,6‐tetrahydropyridinium chloride
Authors: Bosch J. , Domingo A. , Lopez F. , Rubiralta M. 
Published: March 2009

Abstract1,3,3‐Trimethyl‐2‐(3,4,5‐trimethoxyphenyl)‐4‐methylenepiperidine (XI) is prepared in an unambiguous way which involves the Refortmatsky reaction followed by ethanolysis on the N‐(3,4,5‐trimethoxybenzylidene)methylamine, later treatment of the resulting aminoester with ethyl acrylate, ring closure by Dieckmann reaction with decarbalkoxylation and, finally, a Wittig reaction on the piperidone obtained. The resulting methylenepiperidine XI differs in its physical and spectroscopic data from the methylene derivative IIIa obtained by the Stevens rearrangement of the 1,3,4‐trimethyl‐1‐(3,4,5‐trimethoxybenzyl)‐1,2,5,6‐tetrahydropyridinium chloride, whose structure must be reviewed.
Nouvelle synthèse des pyrido[4,3‐b]quinoléines substituées sur leur sommet 1
Authors: Rivalle Christian , Bisagni Emile 
Published: March 2009

AbstractOn décrit une nouvelle synthèse de pyrido[4,3‐b]quinoléines diversement substituées sur leur sommet 1 qui comporte seulement trois étapes. Ainsi, les hydroxy‐2 arylamino‐4 pyridines sont transformées dans les conditions de la réaction de Vilsmeir‐Haack en donnant directement les oxo‐1 dihydro‐1,2 pyrido[4,3‐b]quinoléines; la chloration de ces dernières engendre ensuite les chloro‐1 pyrido[4,3‐b]quinoléines qui sont aisément substituées par des amines variées.
A new procedure for the cyclization of 2‐indole‐ and 3‐indolecarbohydrazones to 5H‐pyridazino[4,5‐b]indole derivatives
Authors: Vega A. Monge , Palop J. A. , Martínez M. T. , Alvarez E. Fernández 
Published: March 2009

AbstractA new procedure for the cyclization of 2‐indolecarbohydrazones (5) to 1,2,3,4‐tetrahydro‐4‐oxo‐5H‐pyridazino[4,5‐b]indoles (6) and for the cyclization of 3‐indolecarbohydrazones (7) to 1‐oxo‐1,2,3,4‐tetrahydro‐5H‐pyridazino[4,5‐b]indoles (8 and 9) is described. The hydrazones (5 or 7) were treated with an acyl halide (acetyl or benzoyl chlorides) and triethylamine in ethyl acetate of chloroform as solvents to give the compounds 6 (20–70%) from the compounds 5, and the compounds 8 (20–60%) from the compounds 7. Through refluxing with ethanol‐hydrochloric acid the compounds 8a‐8f selectively separate the acetyl group on N5 to give the respective compounds, 9a‐9f. The ir and 1H‐nmr spectra of all the compounds 5, 6, 7, 8 and 9 and the uv, mass and 13C‐nmr spectra of the compounds 7h, 7i, 8h and 8i are discussed.
v‐triazolines. Part XIV . 1‐aryl‐5‐dialkylaminomethyl‐4‐methylene‐4,5‐dihydro‐v‐triazoles
Authors: Pocar Donato , Rossi Luisa Maria , Trimarco Pasqualina 
Published: March 2009

AbstractThe cycloaddition of arylazides to 1‐methyl‐ and 1‐benzyl‐2,5‐dihydropyrrole affords pyrrolo[3,4‐d]‐v‐triazole derivatives which react with methyl iodide, yielding the corresponding quaternary ammonium salts. On base‐catalyzed elimination 1‐aryl‐5‐dialkyl‐aminomethyl‐4‐methylene‐4,5‐dihydro‐v‐triazoles are formed. Their structure and behaviour toward methoxide and secondary amines are discussed.
A synthesis of hydrothiopyran‐3‐ones. The intramolecular cyclization of allylthiopropionyl and propargylthioacetyl chlorides
Authors: Ichikawa Kazuo , Inoue Seiichi , Sato Kikumasa 
Published: March 2009

AbstractIntramolecular cyclization of 2‐(allylthio)propionyl chloride (3a) effected by aluminum chloride gave two dihydrothiopyran‐3‐ones (5a,6a) and 5‐chloro‐2‐methyltetrahydrothiopyran‐3‐one (7a). Treatment of propargylthioacetyl chloride (4a) with aluminum chloride afforded 5‐chloro‐3,6‐dihydro‐2H‐thiopyran‐3‐one (10a). The cyclization reactions of related compounds were also studied.
The oxidation of a series of phthalyl alcohols
Authors: Bhattacharjee Debkumar , Popp Frank D. 
Published: March 2009

AbstractA series of phthalyl alcohols containing methoxy and methyl substituents were prepared by lithium aluminum hydride reduction of phthalides. Oxidation of the phthalyl alcohols with activated manganese dioxide or with barium manganate gave phthalaldehydes or phthalides depending on the position of the ring substituents.
Conformations privilegiees de dithieno[c,e]dihydro azepines, oxepinnes et thiepinnes: Etude par spectroscopie d'absorption electronique
Authors: Meunier P. , Arriau J. 
Published: March 2009

AbstractL'étude comparative des spectres d'absorption électronique (uv) de dithiéno[c,e]dihydro “épinnes” et des bithiophènes correspondants permet de conclure à 1′existence privilégiée en solution d'une forme “croisée” pour les composés cycliques étudies. Cette conclusion est confirmee, d'une part par 1′analyse des résultats théoriques (CNDO/S) et, d'autre part, par l'étude de dérives stériquement encombrés.
Sur diverses possibilités de formation de pyrimidines à partir de formyl‐3 chromone
Authors: Pene Cécile , Hubert‐Habart Michel 
Published: March 2009

AbstractLa guanidine transforme: la formyl‐3 chromone en un mélange d'amino‐2 (hydroxy‐2 benzoyl)‐5 pyrimidine et d'amino‐2 hydroxy‐5 5H(1) benzopyranno[4–3‐d]pyrimidine; le diacétate de méthylidyne‐3 chromone en amino‐2 hydroxy‐5 5H(1) benzopyranno[4,3‐d]pyrimidine, et l'ox‐ime de la formyl‐3 chromone en amino‐2 5H(1)benzopyranno[4,3‐d]pyrimidinone‐5. La thiourée, l'acetamidine et la nitroguanidine sont également capables d'engendrer des pyrimidines du měme type avec la formyl‐3 chromone, le diacétate de méthylidyne‐3 chromone ou la (dioxolanne‐1,3 yl‐2)‐3 chromone.
O‐carbamoyl oximes as potential analgesics
Authors: Evenson Gerald N. , Moffett Robert Bruce 
Published: March 2009

AbstractPreparation of oxadiazinones 2, from α‐anilinoacetophenone oximes and O‐carbamoyl‐2,3‐dihydro‐4‐quinolinone oximes 3, from quinolinones are described.
Studies on chemotherapeutics I. Synthesis of 5‐substituted‐4‐oxo‐1,4‐dihydro‐3‐pyridinecarboxylic acid derivatives
Authors: Balogh MÁRia , Hermecz István , Mészaros Zoltán , Simon KÁLman , Pusztay Levente , Horváth GÁBor , Dvortsak Peter 
Published: March 2009

AbstractEthyl 5‐substituted‐4‐oxo‐1,4‐dihydro‐3‐pyridinecarboxylates were synthetized by reacting 1,3,5‐triazine with 4‐substituted ethyl acetoacetate derivatives in ethanol, in the presence of sodium ethoxide. The l‐alkyl‐5‐substituted‐4‐oxo‐1,4‐dihydro‐3‐pyridinecarboxylic acids required for the antimicrobial studies were prepared by N‐alkylation (with triethyl phosphate or alkyl halides) and alkaline hydrolysis of the pyridone esters.
2,3,5,6‐tetramethylmorpholine. V. Mechanism study of cyclization of 3,3′‐iminobis‐2‐butanols
Authors: Hernestam Sven , Stenvall Gillis 
Published: March 2009

AbstractThe mechanism of cyclization of 3,3′‐iminobis‐2‐butanols to 2,3,5,6‐tetramethylmorpholines in sulfuric acid is studied. Contrary to our prior suggestions, the ring closure seems to be exclusively a normal S‐type substitution. The partial inversion before the cyclization is discussed.
Reaction between 2,2′ ‐dithiodianiline and acetylenic ketones or esters. A new synthesis of 4H‐1,4‐benzothiazines
Authors: Liso Gaetano , Trapani Giuseppe , Berardi Vincenza , Marchini Paolo 
Published: March 2009

AbstractThe title compounds (3a‐c) together with the benzothiazolines (4b‐c) were obtained by reaction between 2,2′ ‐dithiodianiline (1) and acetylenic ketone (2a) or esters (2b‐c). A possible pathway involving the formation and subsequent cyclization to 3 of enamine intermediates A and/or B, is suggested.
The synthesis of some 4‐nitroisothiazoles as potential antifungal agents
Authors: Albert Anthony H. , O'Brien Darrell E. , Robins Roland K. 
Published: March 2009

Abstract5‐Chloro‐3‐methyl‐4‐nitroisothiazole (III) was prepared by nitration of 5‐chloro‐3‐methyliso‐thiazole. Compound III was found to exhibit significant antifungal activity in vitro against a wide spectrum of fungi. The synthesis of 3‐methyl‐4‐nitro‐5‐nitroamino, 5‐carboxamido, 5‐N,N‐dimethylamino and 5‐β‐hydroxyethylaminoisothiazole are here reported. The synthesis of 3‐methyl‐4‐nitroso‐5‐ethylthioisothiazole (IX) is reported via an unusual reaction of 5‐bromo‐3‐methyl‐4‐nitroisothiazole (I) and sodium ethyl mercaptide. 5‐Bromo‐4‐nitroisothiazole was prepared by nitration of 5‐bromoisothiazole. The nitro group was shown to be essential for antifungal activity.
A novel ring transformation of uracil into the benzene ring system
Authors: Hirota Kosaku , Kitade Yukio , Senda Shigeo 
Published: March 2009

AbstractReaction of 5‐formyl‐1,3‐dimethyluracil with some active methylene compounds in the presence of base causes novel ring transformations to give the p‐hydroxybenzoates and the nicotinate.
Benzolactams. II. Synthesis of tetrahydrobenz[d]indeno‐[1,2‐b]azepines and their 12‐Oxo derivatives
Authors: Orito Kazuhiko , Kaga Harumi , Itoh Mitsuomi , De Silva S. Osmund , Manske Richard H. , Rodrigo Russel 
Published: March 2009

AbstractAromatic methoxy and/or methylenedioxy substituted 7‐methyltetrahydrobenz[d]indeno[1,2‐b]‐azepines 7 and their 12‐oxo derivatives 8 were efficiently synthesized by the general method consisting of two types of intramolecular dehydrative cyclizations, as follows. N‐Methyl‐N‐β‐phenethylacetamides 1 were cyanomethylated in the two‐step process of chloromethylation and treatment of the resultant benzyl chlorides with sodium cyanide. The condensation of the benzyl cyanides 2 with the appropriate benzaldehydes, followed by reduction of the benzylidene function, gave α,β‐diphenylpropionitriles 3. Successively, hydrolysis to the amino acids 4 and the thermal cyclization converted 3 to the benzylbenzazepinones 5, which were also prepared by benzylation of the benzazepinones 6 smoothly by heating of 5 with phosphoryl chloride to afford the title azepines 7. Further, these tetracyclic enamines 7 underwent autoxidation to the corresponding 12‐oxo derivatives 8, on exposure to oxygen in the presence of Triton B.
Synthesis of 2‐and 6‐chloro‐3‐(5‐methyl‐1,3,4‐oxadiazol‐2‐yl)pyridines
Authors: Ponticello Gerald S. , Engelhardt Edward L. , Baldwin John J. 
Published: March 2009

AbstractA convenient synthesis of 2‐ and 6‐chloro‐3‐(5‐methyl‐1,3,4‐oxadiazol‐2‐yl)pyridines, 3 and 10, utilizing the readily available amide 7 is described. Incorporation of the 3‐t‐butylamino‐2‐hydroxypropoxy side chain onto 3 provided 2, a potential bioisostere of 1. The antihypertensive activities of 2 and 12 were evaluated in the spontaneously hypertensive rat model.
Synthesis of 1,3,4,6,7,11b‐hexahydro‐9,10‐dimethoxy‐11b‐methyl [1,4]thiazino[3,4‐a]isoquinoline derivatives
Authors: Jirkovsky I. , Noureldin R. 
Published: March 2009

AbstractAlkylation of the 2‐mercaptoacetamide 4a with chloropropanone afforded the ketoamide 10 which on direct acid‐catalyzed cyclization furnished 12. The cyclization can be arrested at the stage of the enamide 11. Periodate oxidation of 12 gave the equatorial sulfoxide 14. Reduction of 12 with diborane led to 13 which was oxidized to yield a mixture of sulfoxides 17 and 18. The configuration of 12, 14, 17, and 18 was established on the basis of nmr data. Compounds 12, 14, and 18 showed an interesting degree of antihypertensive activity.
9‐β‐D‐ribopyranosylhypoxanthine, a minor component produced by streptomyces antibioticus
Authors: Kern D. L. , Cook P. D. , French J. C. 
Published: March 2009

Abstract9‐β‐d‐Ribopyranosylhypoxanthine was isolated from fermentation broths of Streptomyces antibioticus. Its structure was proved by synthesis.
Sur les orthoamino formyl quinoléines, nouveaux synthons hétérocycliques
Authors: Godard Alain , Quéguiner Guy 
Published: March 2009

AbstractLes quatre ortho amino formyl quinoléines substituées sur le cycle pyridinique ont été synthétisées par oxydation des amino hydroxyméthyl quinoléines correspondantes. Parmi toutes les méthodes envisagées, seule cette dernière a permis la préparation de l'amino‐3 formyl‐2 quinoléine, composé relativement peu stable. Ces nouveaux composés bifonctionnels dérivés de la quinoléine constituent des synthons particulièrement intéressants pour l'élaboration de certains hétérocycles.
Folate antagonists. 17. Synthesis and biological properties of a 2,4‐diamino‐6‐thioquinazoline analog of aminopterin
Authors: Werbel Leslie M. , Newton Linda , Elslager Edward F. 
Published: March 2009

AbstractA multistep route for the synthesis of N‐[4‐[(2,4‐diamino‐6‐quinazolinyl)thio]benzoyl]‐L‐glutamic acid (2) from 4‐mercaptobenzoic acid and 5‐chloro‐2‐nitrobenzonitrile is described. Although this aminopterin analog lacked significant antimalarial activity, it was a potent inhibitor of dihydrofolate reductase from Trypanosoma cruzi. The pteroic ester analog 11, however, was active against Plasmodium berghei infections in mice at high doses.
4‐Substituted‐3‐alkyl‐3,4‐dihydro‐2H‐1,3‐benzoxazin‐2‐ones. IV (2‐4). Keto‐Enol tautomerism of β‐keto ester derivatives. Reaction of β‐dicarbonyl compounds with diamines
Authors: Bobowski George , Shavel John 
Published: March 2009

AbstractA series of α‐[3‐alkyl‐3,4‐dihydro‐2‐oxo‐2H‐1,3‐benzoxazin‐4‐yl]‐β‐keto ester derivatives 1 (Table I) were synthesized by the condensation of 3‐alkyl‐3,4‐dihydro‐4‐hydroxy‐2H‐1,3‐benzoxazine‐2‐ones 3 (2) with β‐keto esters 4 in the presence of traces of mineral acids under azeotropic conditions. Condensation of 1 with hydrazines 5 gave pyrazolone derivatives 2 (Table II). Condensation of β‐diketone derivatives 6 with hydrazines 5 and with 1,2‐benzenediamine (8) resulted in the formation of pyrazoles (7a‐c) and diazepine derivatives 12 (Table III) and 13, respectively.
Selenium heterocycles. XXXI. Reaction of ethyl propiolate with 5‐phenyl‐2‐thioxo‐1,3‐thiaselenole and 4‐phenyl‐2‐thioxo‐1,3‐dithiole
Authors: Shafiee A. , Assadi F. 
Published: March 2009

AbstractReaction of ethyl propiolate with 4‐phenyl‐2‐thioxo‐1,3‐dithiole afforded 4‐carbethoxy‐2‐thioxo‐1,3‐dithiole in high yield. Reaction of ethyl propiolate with 5‐phenyl‐2‐thioxo‐1,3‐thiaselenole gave 4‐carbethoxy‐2‐thioxo‐1,3‐thiaselenone (IX), 4‐carbethoxy‐2‐selenoxo‐1,3‐dithiole (X) and 5‐carbethoxy‐2‐thioxo‐1,3‐thiaselenole (XI). A possible mechanism for the formation of these compounds is given.
Triphenylphosphonium‐alloxan betaines
Authors: Adams William E. , Heindel Ned D. 
Published: March 2009

AbstractAlloxan and 1,3‐dimethylalloxan react with triarylphosphines to generate zwitterionic adducts involving the phosphorus and the C‐5 carbonyl oxygen atoms of alloxan. The adducts, unlike alloxan, did not induce permanent hyperglycemia but one analog did effect a transient rise in blood glucose.
Dihydrothiazolopurines
Authors: Montgomery John A. , Thomas H. Jeanette 
Published: March 2009

AbstractReaction of 1,2‐dibromoethane with 2‐mercaptoadenine gave both 4‐amino‐7,8‐dihydrothiazolo[2,3‐b]purine (2) and the isomeric 3,6,7,9‐tetrahydro‐9‐iminothiazolo[3,2‐a]purine (3). These tricyclic structures were identified by Raney nickel reduction to the corresponding 3‐ and 1‐ethyladenines.
The synthesis of 2‐methylchromone‐3‐carboxylic acid
Authors: Charlton J. L. , Lypka G. , Sayeed V. 
Published: March 2009

AbstractA new synthesis of 2‐methyl‐4‐oxo‐4H‐1‐benzopyran‐3‐carboxylic acid (2‐methylchromone‐3‐carboxylic acid from salicyloyl chloride and the enamine of ethyl acetoacetate, is described and compared with the classical synthesis.
Studies on the oxidation of phenothiazine derivatives
Authors: Anderson E. L. , Post A. , Staiger D. S. , Warren R. 
Published: March 2009

AbstractThe sulfoxides of pharmacologically active phenothiazine derivatives have been widely studied as biological transformation products in body fluids and tissue (1,2). The majority of the work has been devoted to the development of analytical techniques for detection of these products (2,3,4).
Synthesis and absolute configuration of 3‐ethyl and 3‐n‐propylpyrrolidine
Authors: Bettoni Giancarlo , Cellucci Carla , Berardi Francesco 
Published: March 2009

AbstractOptically active 3‐ethyl and 3‐n‐propylpyrrolidine were prepared by two independent routes from their corresponding succinic acids and the absolute configurations were assigned. Maximum optical rotation was also established through evaluation of the degree of racemization of the products obtained via both synthetic routes.
A convenient and general synthesis of 2‐amino‐1,3,4‐thiadiazoles. Dehydration of acylthiosemicarbazides with methanesulfonic acid
Authors: Kress Thomas J. , Costantino Silvio M. 
Published: March 2009

Abstract2‐Amino‐5‐alkyl and 2‐amino‐5‐aryl‐1,3,4‐thiadiazoles were prepared by the dehydration of 2‐acylthiosemicarbazides with molar equivalents of methanesulfonic acid in refluxing toluene. The synthesis appears to be general.
A benzofuran analog of chloramphenicol
Authors: Bevinakatti Hanamanthsa S. , Badiger Virupax V. 
Published: March 2009

AbstractPreparation of dl‐threo‐2‐dichloroacetamido‐1‐(2‐benzofuranyl)propane‐1,3‐diol (VI), adopting the method of Sorm, et al, has been described. The structures of the final compound (VI) as well as of the two precursors (V and IV) have been confirmed by ir, nmr and mass spectral studies.
The use of 3,5‐dimethyl‐4‐nitroisoxazole for the preparation of α,β‐unsaturated aromatic acids
Authors: Sarti‐Fantoni P. , Donati D. , Fiorenza M. , Moschi E. , Dal Piaz V. 
Published: March 2009

AbstractA series of α,β‐unsaturated aromatic acids were prepared by alkaline hydrolysis of 3‐methyl‐4‐nitro‐5‐styrylisoxazoles.