bluuebunny/crossref_metadata_2025_split huggingface dataset:
Learning mathematics with recursive computer programs
Authors: Peelle Howard A. 
Published: November 2005

Recursion is a powerful idea*—with correspondingly powerful implications for learning and teaching mathematics. Computer scientists have previously pointed out that the use of recursion often permits more lucid and concise descriptions of algorithms [1]; mathematicians know that recursion is a fundamental concept upon which entire systems of mathematics can be built [11]; and, the theory of recursive functions is now developing into an area of mathematics whose importance has been compared with that of geometry and algebra [3].
The purposes of this paper are to illuminate the fundamentals of recursion; to illustrate several recursive computer programs which provide perspicuous representations of certain mathematical procedures; and to invite students and teachers of mathematics to reach greater understandings by trying them.
Computer graphics as an aid to teaching geometric transformations
Authors: McAdams Joseph K. , DeKock Arlan R. 
Published: November 2005

During the past several years, there has been much discussion and controversy over what should be taught in high school mathematics, in general, and in high school geometry, in particular. Numerous mathematicians have encouraged the teaching of transformations as part of the standard high school mathematics curriculum[l-4,6-9]. The results of a recent survey of high school teachers of mathematics indicate that 19% have taught geometric transformations, 26% feel adequately prepared to teach such a topic, and 50% would like to teach the topic if materials were available for the average college prep student[5].
The topic of transformations is important because transformations are a unifying factor in algebra and geometry. Algebra and geometry are essentially the same material taught from different approaches. In particular, the abstract algebraic concept of a group can be conveyed in purely geometric terms by groups of transformations.
How much cai is hidden in commercial software?
Authors: Sobel Helen L. 
Published: November 2005

It is somewhat astonishing to find that a well-developed software package designed for business uses provides an extremely interesting teaching instrument with an as yet unrealized potential
For many years report generating systems such as REPORTER have been extensively used as work horses in business and industry. Administrators in these areas require up-to-date information presented in an understandable, well-organized form. The business executive may need a daily, weekly, or monthly report of the sales records of the company's employees, listing for each sales representative the number of items sold in each category, the amount of income produced, the number of items returned in each category, etc.

The Burroughs
REPORT
writ
ER
is based upon an entirely different premise which not only permits but encourages user involvement and understanding. The programs which create each REPORT are accessible, small, modular in structure, and limited to the specific options requested by the user. While it can be easily used in a non-technical manner, and need not be explored in any depth, there are no formidable barriers to a more intelligent mastery of this tool.

The unique characteristic of the Burroughs REPORTER is its production of an independent COBOL program for each set of specifications entered. It
Computing science courses - training or education?
Authors: Willis Neil 
Published: November 2005

The debate about the usefulness or otherwise of Computing Science degrees has raged for some time.
Critics of these degree courses have stated that the courses do not satisfy the needs of commercial and industrial users; that they do not train the graduate to be of immediate use or that the subject is developing too rapidly for degrees to impart any lasting knowledge and so on.

It may be (and is) argued by some, that an Institute of Higher Education (be it College, Polytechnic* or University) should not aim to train students to be of immediate use to industry. However there is obviously a demand for trained personnel in the computing field, as demonstrated by the proliferation of courses run by manufacturers, various professional bodies and commercial organizations, and it is to satisfy this demand that a number of Polytechnics in England, and Sheffield Polytechnic in particular, have designed courses aimed at
educating
students in the field of computing.
A computer-aided flow diagram teaching system
Authors: Koffman Elliot B. , Friedman Frank L. 
Published: November 2005

This paper describes a system intended to aid beginning computer science students develop a systematic approach towards problem solution using structured flow diagrams. The student is carefully monitored during the specification of an initial flow diagram and through successive stages of refinement. As each new flow diagram symbol is entered, the system checks to see that the student is being consistent with earlier work and has not introduced potential errors.
The flow diagram is an intermediate level representation of an algorithm which is independent of the particular programming language chosen for implementation. When the structured flow diagram has been completely refined, the final translation to a programming language is relatively automatic. To test the program logic, the resultant source code should be executed. The student can modify the flow diagram, generate new code, and re-execute until the program runs correctly.
A unique graduate program in computer science at Jackson State University
Authors: Iynengar S. Sitharama , Lewis Jesse C. 
Published: November 2005

The two key elements of decision-making in today's environment are (i)efficient information processing and management and (ii) a degree of maturity in effective use of a broad range of analytical tools and techniques which pass under the general label of Mathematical Sciences.
The Department of Computer Science at Jackson State University started a Graduate Program during the 1974 academic year which offers a unique interdisciplinary program leading to a Master's Degree in Computer Science. This program emphasizes in programming languages, systems programming, operating systems, information systems analysis and design, the role of the computer as an integral part of the decision-making process, and the computer applications in the areas of statistics and management science. Advanced placement may be given via examination or acceptable certificate presentation from traditional or non-traditional institutions such as IBM Corporation. The students are presently using both the interactive and the batch capability of our IBM 360/40 for their course and project works. The university is upgrading to an IBM 370/145 during the spring semester (1976).
A video disc oriented educational system
Authors: Michalopoulos Demetrios A. 
Published: November 2005

One of the challenging fields of computer science is the computer graphics field which, because of its relatively high cost, has not been used extensively for educational purposes. Recent hardware developments in the graphics technology and price breakthroughs in digital equipment are beginning to influence the educational uses of computer graphics. If “a picture is worth a thousand words” and if the cost is not at this ratio, one can provide the student, not necessarily of computer sciences, with the possibility of a continuous interaction in which the student can see the results of his decision and thus allows him to experiment and practice with ideas not completely understood yet.
This paper presents a design for an interactive educational system incorporating the recent development of the video-disc.
Suppression of Urokinase Receptor Expression by Thalidomide Is Associated with Inhibition of Nuclear Factor κB Activation and Subsequently Suppressed Ovarian Cancer Dissemination
Authors: Kobayashi Hiroshi , Yagyu Tatsuo , Kondo Toshiharu , Kurita Noriyuki , Inagaki Kiyokazu , Haruta Shoji , Kawaguchi Ryuji , Kitanaka Takashi , Sakamoto Yoshiharu , Yamada Yoshihiko , Kanayama Naohiro , Terao Toshihiko 
Published: November 2005

AbstractThalidomide has been used to treat a variety of diseases ranging from alleviation of autoimmune disorders to prevention of metastasis of cancers. It has been shown previously that increased levels of urokinase-type plasminogen activator receptor (uPAR) correlate well with higher invasive phenotype. We examined whether thalidomide is able to suppress the expression of uPAR mRNA and protein in human ovarian cancer cell line HRA and human chondrosarcoma cell line HCS-2/8. Here, we show that: (a) thalidomide suppresses the expression of constitutive and transforming growth factor-β1 (TGF-β1)–induced uPAR mRNA and protein; (b) a nuclear factor κB (NF-κB) activation system (phosphorylation of IκB-α and degradation of IκB-α) is necessary for the TGF-β1-induced increase in uPAR expression, because l-1-tosylamido-2-phenylethyl chloromethyl ketone, a NF-κB inhibitor, reduced the uPAR production as well as mRNA expression; (c) thalidomide failed to further strengthen l-1-tosylamido-2-phenylethyl chloromethyl ketone's action; (d) the once-daily i.p. administration of thalidomide (400 μg/g body weight/d) decreased progressive growth of HRA tumors and ascites formation in an in vivo animal model; and (e) the once-daily i.p. administration of thalidomide in combination with paclitaxel (i.p., 100 μg/20 g at days 2 and 5) significantly decreased progressive growth of HRA cells in a synergistic fashion. We conclude that thalidomide down-regulates constitutive and TGF-β1-stimulated uPAR mRNA and protein expression possibly through suppression of NF-κB activation. Furthermore, combination therapy with thalidomide plus paclitaxel may be an effective way to markedly reduce i.p. tumor growth and ascites in ovarian cancer dissemination.
Magnetic Resonance Imaging Visualization of Hyaluronidase in Ovarian Carcinoma
Authors: Shiftan Liora , Israely Tomer , Cohen Miriam , Frydman Veronica , Dafni Hagit , Stern Robert , Neeman Michal 
Published: November 2005

AbstractHyaluronan, a high molecular weight, negatively charged polysaccharide, is a major constituent of the extracellular matrix. High molecular weight hyaluronan is antiangiogenic, but its degradation by hyaluronidase generates proangiogenic breakdown products. Thus, by expression of hyaluronidase, cancer cells can tilt the angiogenic balance of their microenvironment. Indeed, hyaluronidase-mediated breakdown of hyaluronan correlates with aggressiveness and invasiveness of ovarian cancer metastasis and with tumor angiogenesis. The goal of this work was to develop a novel smart contrast material for detection of hyaluronidase activity by magnetic resonance imaging (MRI). Gadolinium-diethylenetriaminepentaacetic acid (GdDTPA) covalently linked to hyaluronan on the surface of agarose beads showed attenuated relaxivity. Hyaluronidase, either purified from bovine testes or secreted by ES-2 and OVCAR-3 human epithelial ovarian carcinoma cells, activated the hyaluronan-GdDTPA-beads by rapidly altering the R1 and R2 relaxation rates. The change in relaxation rates was consistent with the different levels of biologically active hyaluronidase secreted by those cells. Hyaluronan-GdDTPA-beads were further used for demonstration of MRI detection of hyaluronidase activity in the proximity of s.c. ES-2 ovarian carcinoma tumors in nude mice. Thus, hyaluronan-GdDTPA-beads could allow noninvasive molecular imaging of hyaluronidase-mediated tilt of the peritumor angiogenic balance.
Mutation of the PIK3CA Gene in Anaplastic Thyroid Cancer
Authors: García-Rostán Ginesa , Costa Angela M. , Pereira-Castro Isabel , Salvatore Giuliana , Hernandez Radhames , Hermsem Mario J.A. , Herrero Agustin , Fusco Alfredo , Cameselle-Teijeiro Jose , Santoro Massimo 
Published: November 2005

Abstract
The phosphatidylinositol 3′-kinase (PI3K) pathway is frequently activated in thyroid carcinomas through the constitutive activation of stimulatory molecules (e.g., Ras) and/or the loss of expression and/or function of the inhibitory PTEN protein that results in Akt activation. Recently, it has been reported that somatic mutations within the PI3K catalytic subunit, PIK3CA, are common (25-40%) among colorectal, gastric, breast, ovarian cancers, and high-grade brain tumors. Moreover, PIK3CA mutations have a tendency to cluster within the helical (exon 9) and the kinase (exon 20) domains. In this study, 13 thyroid cancer cell lines, 80 well-differentiated thyroid carcinomas of follicular (WDFC) and papillary (WDPC) type, and 70 anaplastic thyroid carcinomas (ATC) were investigated, by PCR-direct sequencing, for activating PIK3CA mutations at exons 9 and 20. Nonsynonymous somatic mutations were found in 16 ATC (23%), two WDFC (8%), and one WDPC (2%). In 18 of the 20 ATC cases showing coexisting differentiated carcinoma, mutations, when present, were restricted to the ATC component and located primarily within the kinase domain. Three cell lines of papillary and follicular lineage (K1, K2, and K5) were also found mutated. In addition, activation of Akt was observed in most of the ATC harboring PIK3CA mutations. These findings indicate that mutant PIK3CA is likely to function as an oncogene among ATC and less frequently well-differentiated thyroid carcinomas. The data also argue for a role of PIK3CA targeting in the treatment of ATC patients.
HLA-G Proteins in Cancer: Do They Provide Tumor Cells with an Escape Mechanism?
Authors: Rouas-Freiss Nathalie , Moreau Philippe , Ferrone Soldano , Carosella Edgardo D. 
Published: November 2005

Abstract
Convincing clinical evidence indicates that the limited success of T-cell–based immunotherapy of malignant diseases is caused, at least in part, by the ability of malignant cells to escape from immune recognition and destruction. Among the multiple escape mechanisms identified, a major role is played by changes in the expression and/or function of HLA antigens expressed by tumor cells, because they may markedly affect tumor cell-host's immune system interactions. In this article, we review the data about the aberrant expression of the nonclassical HLA class I antigen HLA-G by tumor cells. Furthermore, we discuss the possible reasons for the conflicting information in the literature about HLA-G antigen expression by malignant cells. Lastly, in light of the well-documented immunotolerant function of HLA-G, we discuss the potential role of these antigens in the escape of tumor cells from immune recognition and destruction and in the clinical course of malignant diseases.
Laminin α5 Chain Metastasis- and Angiogenesis-Inhibiting Peptide Blocks Fibroblast Growth Factor 2 Activity by Binding to the Heparan Sulfate Chains of CD44
Authors: Hibino Suguru , Shibuya Masahiko , Hoffman Matthew P. , Engbring Jean A. , Hossain Rydhwana , Mochizuki Mayumi , Kudoh Shoji , Nomizu Motoyoshi , Kleinman Hynda K. 
Published: November 2005

Abstract
Recently, we reported that the laminin α5 synthetic peptide A5G27 (RLVSYNGIIFFLK, residues 2,892-2,904) binds to the CD44 receptor of B16-F10 melanoma cells via the glycosaminoglycans on CD44 and inhibits tumor cell migration, invasion, and angiogenesis in a dominant-negative manner. Here, we have identified the potential mechanism of A5G27 activity using WiDr human colorectal carcinoma cells. WiDr cells bound to the laminin A5G27 peptide via the heparin-like and chondroitin sulfate B glycosaminoglycan side chains of CD44. Cell binding to fibroblast growth factor (FGF2) was blocked by laminin peptide A5G27 but not by either a scrambled version of this peptide or by another laminin peptide known to bind cell surface proteoglycans. FGF2 signaling involving tyrosine phosphorylation was also blocked by laminin peptide A5G27 but was not affected by peptide controls. Finally, we have shown that peptide A5G27 directly blocks FGF2 binding to heparin. Peptide A5G27 has sequence homology to a region on FGF2 that binds heparin and the FGF receptor and is important in FGF2 central cavity formation. We conclude that peptide A5G27 inhibits metastasis and angiogenesis by blocking FGF2 binding to the heparan sulfate side chains of CD44 variant 3, thus decreasing FGF2 bioactivity.
Expression Microarray Analysis and Oligo Array Comparative Genomic Hybridization of Acquired Gemcitabine Resistance in Mouse Colon Reveals Selection for Chromosomal Aberrations
Authors: van de Wiel Mark A. , Costa Jose L. , Smid Kees , Oudejans Cees B.M. , Bergman Andries M. , Meijer Gerrit A. , Peters Godefridus J. , Ylstra Bauke 
Published: November 2005

Abstract
Gemcitabine is a commonly used therapy for many solid tumors. Acquired resistance to this nucleoside analogue, however, diminishes the long-term effectiveness in a majority of patients. To better define the molecular background of gemcitabine resistance, a mouse colon tumor was selected during successive rounds of transplantation with continued treatment of gemcitabine. Expression microarray analysis was applied to determine which genes are consistently and highly overexpressed or underexpressed in the resistant versus the nonresistant tumor. For the statistical interpretation of the microarray data, a parametric model was implemented, which returns model-based differential gene expression (log-) ratios and their uncertainties. This defined a set of 13 genes, putatively responsible for the gemcitabine resistance in solid tumors. One of these, RRM1, was previously identified as an important marker for gemcitabine resistance in human cell lines. Five of the 13 genes, including RRM1, are located within a 3 Mb region at chromosome 7E1 of which four are highly overexpressed, suggesting a chromosomal amplification. Therefore, chromosomal copy number changes were measured, using oligo array comparative genomic hybridization. A narrow and high amplification area was identified on 7E1 that encompassed all five genes. In addition, reduced RNA expression of two other genes at 8E1 encoding COX4I1 and RPL13 could be explained by a decrease in chromosomal copy number on chromosome 8. In conclusion, the array comparative genomic hybridization biologically validates our statistical approach and shows that gemcitabine is capable to select for chromosomally aberrant tumor cells, where changed gene expression levels lead to drug resistance.
Interleukin-8 Differentially Regulates Migration of Tumor-Associated and Normal Human Brain Endothelial Cells
Authors: Charalambous Christiana , Pen Ligaya B. , Su Yuzhuang S. , Milan Johanna , Chen Thomas C. , Hofman Florence M. 
Published: November 2005

AbstractInterleukin-8 (IL-8) is a chemokine involved in angiogenesis, a process vital to tumor growth. Previously, we showed that endothelial cells derived from human tumor tissue have different functional and phenotypic properties compared with normal endothelial cells. This study analyzes the role of IL-8 in regulating angiogenesis of tumor-associated brain endothelial cells (TuBEC). Results show that TuBECs have a higher baseline migration rate compared with normal brain endothelial cells (BEC). TuBECs are unaffected when stimulated with IL-8 whereas BECs are activated. This lack of response of TuBECs to IL-8 is due to the constitutive production of IL-8. Endogenously produced IL-8 activates TuBECs in an autocrine manner as shown by IL-8 receptor inhibition. Blocking either CXCR1 or CXCR2 partially reduces TuBEC migration, whereas blocking both receptors further reduces migration. Treatment with antibody against vascular endothelial growth factor (VEGF) shows that production of IL-8 by TuBECs is dependent on VEGF. Transforming growth factor-β1 (TGF-β1), shown to down-regulate IL-8 production in BECs, does not inhibit IL-8 production in TuBECs. In summary, these studies show that TuBECs constitutively secrete IL-8 and autocrine activation by IL-8 is the result of VEGF stimulation. Furthermore, TuBECs do not respond to the feedback inhibition normally induced by TGF-β1. These data emphasize the functional uniqueness of TuBECs. Understanding the functions and regulatory processes of tumor-associated endothelial cells is critical for developing appropriate antiangiogenic therapies.
Transforming Growth Factor-β Activation of Phosphatidylinositol 3-Kinase Is Independent of Smad2 and Smad3 and Regulates Fibroblast Responses via p21-Activated Kinase-2
Authors: Wilkes Mark C. , Mitchell Hugh , Penheiter Sumedha Gulati , Doré Jules J. , Suzuki Kaori , Edens Maryanne , Sharma Deepak K. , Pagano Richard E. , Leof Edward B. 
Published: November 2005

Abstract
Transforming growth factor-β (TGF-β) stimulates cellular proliferation and transformation to a myofibroblast phenotype in vivo and in a subset of fibroblast cell lines. As the Smad pathway is activated by TGF-β in essentially all cell types, it is unlikely to be the sole mediator of cell type–specific outcomes to TGF-β stimulation. In the current study, we determined that TGF-β receptor signaling activates phosphatidylinositol 3-kinase (PI3K) in several fibroblast but not epithelial cultures independently of Smad2 and Smad3. PI3K activation occurs in the presence of dominant-negative dynamin and is required for p21-activated kinase-2 kinase activity and the increased proliferation and morphologic change induced by TGF-β in vitro.
Uncoupling between Epidermal Growth Factor Receptor and Downstream Signals Defines Resistance to the Antiproliferative Effect of Gefitinib in Bladder Cancer Cells
Authors: Kassouf Wassim , Dinney Colin P.N. , Brown Gordon , McConkey David J. , Diehl Alan J. , Bar-Eli Menashe , Adam Liana 
Published: November 2005

AbstractActivation of the epidermal growth factor receptor (EGFR) and downstream signaling pathways, such as phosphatidylinositol-3 kinase/Akt and Ras/mitogen-activated protein kinase (MAPK), have been implicated in causing resistance to EGFR-targeted therapy in solid tumors, including the urogenital tumors. To investigate the mechanism of resistance to EGFR inhibition in bladder cancer, we compared EGFR tyrosine kinase inhibitor (Gefitinib, Iressa, ZD1839) with respect to its inhibitory effects on three kinases situated downstream of EGFR: MAPK, Akt, and glycogen synthase kinase-3β (GSK-3β). We found that the resistance to the antiproliferative effects of gefitinib, in vitro as well as in vivo in nude mice models, was associated with uncoupling between EGFR and MAPK inhibition, and that GSK-3β activation and degradation of its target cyclin D1 were indicators of a high cell sensitivity to gefitinib. Further analysis of one phenotypic sensitive (253J B-V) and resistant (UM-UC13) cell lines revealed that platelet-derived growth factor receptor-β (PDGFRβ) activation was responsible for short circuiting the EGFR/MAPK pathway for mitogenic stimuli. However, invasion as well as actin dynamics were efficiently reduced by EGFR inhibition in UM-UC13. Chemical disruption of signaling pathways or of PDGFR kinase activity significantly reduced the inactive pool of cellular GSK-3β in UM-UC13 cells. In conclusion, our data show that the uncoupling of EGFR with mitogenic pathways can cause resistance to EGFR inhibition in bladder cancer. Although this uncoupling may arise through different mechanisms, we suggest that the resistance of bladder cancer cells to EGFR blockade can be predicted early in the course of treatment by measuring the activation of GSK-3β and of nuclear cyclin D1.