bluuebunny/crossref_metadata_2025_split huggingface dataset:
A short‐term operational planning model for natural gas production systems
Authors: Selot Ajay , Kuok Loi Kwong , Robinson Mark , Mason Thomas L. , Barton Paul I. 
Published: December 2007

AbstractA short‐term operational planning model for natural gas production systems can help identify a consistent operational policy that satisfies contractual rules and customer specifications. Formulating and solving such a model poses challenges due to nonlinear pressure‐flowrate relations, a multicommodity network and complex production‐sharing contracts (PSC). A production allocation model is presented that can be viewed as a contractual model superimposed on an infrastructure model. The infrastructure model incorporates nonlinear pressure‐flowrate relationships for wells and pipelines, multiple qualities of gas in the trunkline network and models of facilities. The contractual model is a mathematical representation of the PSC and associated operational rules. The model features are inspired by the Sarawak Gas Production System (SGPS) in East Malaysia. A case study similar to the Sarawak Gas Production System (SGPS) is presented. The final formulation is a nonconvex mixed‐integer nonlinear program and is solved with GAMS/BARON to global optimality. A hierarchical multiobjective operational study is also presented. © 2007 American Institute of Chemical Engineers AIChE J, 2008
Wisecrackers: A theory‐grounded investigation of phishing and pretext social engineering threats to information security
Authors: Workman Michael 
Published: December 2007

AbstractThe collection and dissemination of information about people by businesses and governments is ubiquitous. One of the main threats to people's privacy comes from human carelessness with this information, yet little empirical research has studied behaviors associated with information carelessness and the ways that people exploit this vulnerability. The studies that have investigated this im‐portant question have not been grounded in theory. In particular, the extant literature reveals little about social engineering threats and the reasons why people may or may not fall victim. Synthesizing theory from the marketing literature to explain consumer behavior, an empirical field study was conducted to see if factors that account for successful marketing campaigns may also account for successful social engineering attacks.
Pharmacokinetics of riluzole: evidence for glucuronidation as a major metabolic pathway not associated with UGT1A1 genotype
Authors: van Kan H. J. M. , van den Berg L. H. , Groeneveld G. J. , van der Straaten R. J. H. M. , van Vught P. W. J. , Lie‐A‐Huen L. , Guchelaar H.‐J. 
Published: December 2007

AbstractPharmacokinetic studies of riluzole show a large inter‐individual variability of the drug's clearance and serum concentrations. Optimizing the individual dosage of riluzole may have the potential to improve the effect of riluzole treatment on survival of patients with amyotrophic lateral sclerosis (ALS).Limited data are available on thein vivometabolic elimination of riluzole. Fromin vitroexperiments, CYP1A2 seems to be mainly involved in riluzole clearance. However,in vitrostudies suggest that formation of riluzole‐glucuronide plays a role and may determine the drug's pharmacokinetic variability in patients to some extent.In the current study the formation of riluzole‐glucuronide was examined in amyotrophic lateral sclerosis (ALS) patients. It also aimed at relating glucuronidation of riluzole to differential UGT1A1*28 genotypes.The formation of riluzole‐glucuronide was confirmed in serum from a group of 14 ALS patients taking riluzole. Riluzole‐glucuronide concentrations were positively associated with those of riluzole. In a separate group of 131 ALS patients taking riluzole, the UGT1A1*28 genotype was not associated with trough or peak serum concentrations of riluzole.This study provides evidence that thein vivometabolic elimination of riluzole in ALS patients involves glucuronidation. The results do not indicate that glucuronidation of riluzole highly contributes to the drug's inter‐individual pharmacokinetic variability. Copyright © 2007 John Wiley & Sons, Ltd.
Interpretation of skeletal variations for human risk assessment: delayed ossification and wavy ribs
Authors: Carney Edward W. , Kimmel Carole A. 
Published: December 2007

AbstractDelayed (or incomplete) ossification of developing fetal bones and wavy ribs are some of the most common skeletal variations encountered in regulatory guideline developmental toxicity studies. Although they tend to be regarded as minor effects, they can be quite sensitive and consequently may influence the study lowest‐observed‐adverse‐effect levels (LOAELs), and thus, impact classification, labeling, and risk assessment. In this study, we review the underlying mechanisms of these skeletal variations, evaluate different scenarios in which they have been observed, offer guidance for their interpretation, and comment on their use for risk assessment. Both minor delays in ossification and wavy ribs seem to be readily repairable via postnatal skeletal remodeling, are not mechanistically linked to malformation, and often are seen in the presence of maternal or fetal toxicity. As such, these minor variations would not generally be considered adverse in and of themselves but should be interpreted in the context of other maternal and fetal findings, information available on normal skeletogenesis patterns, mode of action of the test agent, and historical control incidence using a weight of evidence approach. Birth Defects Res 80:473–496, 2007. © 2007 Wiley‐Liss, Inc.
Multi‐way models for sensory profiling data
Authors: Bro Rasmus , Qannari El Mostafa , Kiers Henk A. L. , Næs Tormod , Frøst Michael Bom 
Published: December 2007

AbstractOne of the problems in analyzing sensory profiling data is to handle the systematic individual differences in the assessments from different panelists. It is unavoidable that different persons have, at least to a certain degree, different perceptions of the samples as well as a different understanding of the attributes or of the scales used for quantifying the assessments. Hence, any model attempting to describe sensory profiling data needs to deal with individual differences; either implicitly or explicitly. In this paper, a unifying family of models is proposed based on (i) the assumption that latent variables are appropriate for sensory data, and (ii) that individual differences occur. Based on how individual differences occur, various mathematical models can be constructed, all aiming at modeling simultaneously the sample‐specific variation and the panelist‐specific variation. The model family includes Principal Component Analysis (PCA) and PARAllel FACtor analysis (PARAFAC). The paper can be viewed as extending the latent variable approach commonly based on PCA to multi‐way models that specifically take certain panelist‐variations into account. The proposed model family is focused on analyzing data from quantitative descriptive analysis with fixed vocabulary, but it also provides a foundation upon which comparisons, extensions and further developments can be made. An example is given which shows that even for well‐working data, models handling individual differences can shed important light on differences between the quality of the data from individual panelists. Copyright © 2007 John Wiley & Sons, Ltd.
ST‐PLS: a multi‐directional nearest shrunken centroid type classifier via PLS
Authors: Sæbø Solve , Almøy Trygve , Aarøe Jørgen , Aastveit Are H. 
Published: December 2007

AbstractThe nearest shrunken centroid (NSC) Classifier is successfully applied for class prediction in a wide range of studies based on microarray data. The contribution from seemingly irrelevant variables to the classifier is minimized by the so‐called soft‐thresholding property of the approach. In this paper, we first show that for the two‐class prediction problem, the NSC Classifier is similar to a one‐component discriminant partial least squares (PLS) model with soft‐shrinkage of the loading weights. Then we introduce the soft‐threshold‐PLS (ST‐PLS) as a general discriminant‐PLS model with soft‐thresholding of the loading weights of multiple latent components. This method is especially suited for classification and variable selection when the number of variables is large compared to the number of samples, which is typical for gene expression data. A characteristic feature of ST‐PLS is the ability to identify important variables in multiple directions in the variable space. Both the ST‐PLS and the NSC classifiers are applied to four real data sets. The results indicate that ST‐PLS performs better than the shrunken centroid approach if there are several directions in the variable space which are important for classification, and there are strong dependencies between subsets of variables. Copyright © 2007 John Wiley & Sons, Ltd.
Repeated stress alters dendritic spine morphology in the rat medial prefrontal cortex
Authors: Radley Jason J. , Rocher Anne B. , Rodriguez Alfredo , Ehlenberger Douglas B. , Dammann Mark , McEwen Bruce S. , Morrison John H. , Wearne Susan L. , Hof Patrick R. 
Published: December 2007

AbstractAnatomical alterations in the medial prefrontal cortex (mPFC) are associated with hypothalamopituitary adrenal (HPA) axis dysregulation, altered stress hormone levels, and psychiatric symptoms of stress‐related mental illnesses. Functional imaging studies reveal impairment and shrinkage of the mPFC in such conditions, and these findings are paralleled by experimental studies showing dendritic retraction and spine loss following repeated stress in rodents. Here we extend this characterization to how repeated stress affects dendritic spine morphology in mPFC through the utilization of an automated approach that rapidly digitizes, reconstructs three dimensionally, and calculates geometric features of neurons. Rats were perfused after being subjected to 3 weeks of daily restraint stress (6 hours/day), and intracellular injections of Lucifer Yellow were made in layer II/III pyramidal neurons in the dorsal mPFC. To reveal spines in all angles of orientation, deconvolved high‐resolution confocal laser scanning microscopy image stacks of dendritic segments were reconstructed and analyzed for spine volume, surface area, and length using a Rayburst‐based automated approach (8,091 and 8,987 spines for control and stress, respectively). We found that repeated stress results in an overall decrease in mean dendritic spine volume and surface area, which was most pronounced in the distal portion of apical dendritic fields. Moreover, we observed an overall shift in the population of spines, manifested by a reduction in large spines and an increase in small spines. These results suggest a failure of spines to mature and stabilize following repeated stress and are likely to have major repercussions on function, receptor expression, and synaptic efficacy. J. Comp. Neurol. 507:1141–1150, 2008. © 2007 Wiley‐Liss, Inc.
Adaptive finite element approximation of multiphysics problems
Authors: Larson Mats G. , Bengzon Fredrik 
Published: December 2007

AbstractSimulation of multiphysics problems is a common task in applied research and industry. Often a multiphysics solver is built by connecting several single‐physics solvers into a network. In this paper, we develop a basic adaptive methodology for such multiphysics solvers. The adaptive methodology is based on a posteriori error estimates that capture the influence of the discretization errors in the different solvers on a given functional output. These estimates are derived using duality‐based techniques. Copyright © 2007 John Wiley & Sons, Ltd.
Cytogenetic analysis of 101 skull base tumors
Authors: Gil Ziv , Orr‐Urtreger Avi , Voskoboinik Nadia , Trejo‐Leider Leonor , Shomrat Ruth , Fliss Dan M. 
Published: December 2007

AbstractBackground.Skull base tumors are rare neoplasms and the cytogenetic data on these tumors are limited. The authors cytogenetically analyzed a large series of tumors and compared the findings with patients' pathologic data.Methods.The karyotypes of pathologically confirmed samples of 101 patients, who were operated for oncological extirpation of tumors, were analyzed using G‐banding and spectral‐karyotyping techniques.Results.Of the 67 malignant tumors, 32 (48%) had chromosomal aberrations, some with complex numerical and structural chromosomal anomalies. Recurrent chromosomal breakpoints were identified in squamous cell carcinomas, adenoid cystic carcinomas (ACCs), sinonasal undifferentiated carcinomas, chordomas, and sarcomas. Specific breakpoints established the diagnosis of various soft tissue sarcomas. Novel chromosomal aberrations were found in various other malignant and benign tumors.Conclusion.This study highlights the value of cytogenetic analysis for diagnosis of skull base tumors. The data add further information on the biological behavior of these rare neoplasms. © 2007 Wiley Periodicals, Inc. Head Neck, 2008
Determinants of public satisfaction with the National Health Insurance in South Korea
Authors: Lee Sang‐Yi , Suh Nam Kyu , Song Jung‐Kook 
Published: December 2007

AbstractTo explore the determinants of public satisfaction with the National Health Insurance, this study re‐analyzed the 2004 public satisfaction survey with the Korean National Health Insurance (KNHI) conducted by Korean National Health Insurance Corporation (KNHIC). One thousand samples were selected with probability proportional to population size (by region/sex/age). The data collected by home‐visit interview were transformed into the final data set by matching them to the insured's benefit database and the qualification database. The results showed that metropolitan residence, insured type, relationship between respondent and householder, subjective health status, benefit–cost ratio, and attitudes toward KNHI were direct determinants of satisfaction with KNHI. In addition, various demographic and socioeconomic variables and the health status of the respondent's family indirectly influenced satisfaction with KNHI. Among these variables, the attitude toward KNHI was the most vital factor to determine public satisfaction. The study results show that equity in monthly contributions and an enhanced quantity and quality of medical services are required to improve public satisfaction with KNHI. Furthermore, it is important to improve the public perception of social values and solidarity for increased public satisfaction with KNHI. Copyright © 2007 John Wiley & Sons, Ltd.
Quantifying the supply‐side benefits from forward contracting in wholesale electricity markets
Authors: Wolak Frank A. 
Published: December 2007

AbstractThe assumption of expected profit‐maximizing bidding behavior in a multi‐unit, multi‐period auction with step‐function supply curves is used to estimate cost functions for electricity generation units and derive tests of expected profit‐maximizing behavior. Applying these techniques to data from the National Electricity Market in Australia reveals statistically significant evidence of output‐dependent marginal costs within and across half‐hours of the day, but no evidence against the hypothesis of expected profit‐maximizing behavior. These cost function estimates quantify the economic significance of output‐varying costs and how forward financial contract obligations impact the amount of these costs the generation unit owner incurs. This supplier's existing obligations imply average daily production costs that are 8% lower than the profit‐maximizing pattern of output with no forward contract obligations. Copyright © 2007 John Wiley & Sons, Ltd.
Finite sample inference methods for dynamic energy demand models
Authors: Bernard Jean‐Thomas , Idoudi Nadhem , Khalaf Lynda , Yélou Clément 
Published: December 2007

AbstractThis paper considers finite sample motivated inference methods in dynamic energy demand models, in which case commonly used econometric methods remain asymptotic. We focus on structural stability, and on exact confidence set estimation of elasticities. We account for intractable and nuisance parameter dependant distributions through Monte Carlo test procedures. For long‐run elasticities which depend on parameter ratios, we assess available asymptotic and exact methods with Fieller based alternatives. Fieller based and exact methods invert approximate and exact relevant test criteria (respectively) and may lead to unbounded set estimates. Our empirical results underscore the importance of using identification‐robust inference methods. Copyright © 2007 John Wiley & Sons, Ltd.
Estimating market power in a two‐sided market: The case of newspapers
Authors: Argentesi Elena , Filistrucchi Lapo 
Published: December 2007

AbstractThe newspaper industry is a two‐sided market: the readers market and the advertising market are closely linked by inter‐market network externalities. We estimate market power in the Italian newspaper industry by building a structural model which encompasses a demand estimation for differentiated products on both sides of the market and where profit maximization by the publishing firms takes into account the interaction between them. The question that we address is whether the observed price pattern is consistent with profit‐maximizing behaviour by competing firms or is instead driven by some form of (tacit or explicit) coordinated practice. Copyright © 2007 John Wiley & Sons, Ltd.
Bone vascular supply in monitor lizards (Squamata: Varanidae): Influence of size, growth, and phylogeny
Authors: de Buffrénil Vivian , Houssaye Alexandra , Böhme Wolfgang 
Published: December 2007

AbstractBone vascular canals occur irregularly in tetrapods; however, the reason why a species has or lacks bone canals remains poorly understood. Basically, this feature could depend on phylogenetic history, or result from diverse causes, especially cortical accretion rate. The Varanidae, a monophyletic clade that includes species with impressive size differences but similar morphologies, is an excellent model for this question. Cortical vascularization was studied in 20 monitor species, on three bones (femur, fibula, and tibia) that differ in their shaft diameters, and in the absolute growth speed of their diaphyseal cortices. In all species smaller than 398 mm SVL (133–397 mm in sample), bone cortices lack vascular canals, whereas all larger species (460–1,170 mm in sample) display canals. The size 398–460 mm SVL is thus a threshold for the appearance of the canals. The distribution of vascular and avascular bone tissues among species does not precisely reflect phylogenetic relationships. When present, vascular canals always occur in the femur and tibia, but are less frequent, sparser, and thinner in the fibula. Vascular density increases linearly with specific size but decreases exponentially during individual growth. In most species, canal orientation varies between individuals and is diverse in a single section. No clear relationship exists between canal orientation and vascular density. These results suggest that: a) the occurrence and density of bone vascular canals are basically dependant on specific size, not phylogenetic relationships; b) vascular density reflects the absolute growth rates of bone cortices; c) the orientation of vascular canals is a variable feature independent of phylogeny or growth rate. J. Morphol., 2008. © 2007 Wiley‐Liss, Inc.
Functional anatomy of the limbs of erethizontidae (Rodentia, Caviomorpha): Indicators of locomotor behavior in Miocene porcupines
Authors: Candela Adriana M. , Picasso Mariana B.J. 
Published: December 2007

AbstractFunctional analysis of the limb bones of the erethizontid Steiromys duplicatus, one of the most abundant Miocene porcupines from Patagonia, provides evidence to infer their locomotor behavior. Remains of the giant Neosteiromys pattoni (Late Miocene of Northeast Argentina) are also analyzed. Osteological and myological features of extant porcupines were evaluated and used as a model to interpret the functional significance of Miocene species' limbs. Several features in erethizontids are compatible with the ability to climb: the low humeral tuberosities indicate a mobile gleno‐humeral joint; the prominent and distally extended deltopectoral crest indicates a powerful pectoral muscle, which is particularly active when climbing; the humero‐ulnar and humero‐radial joints are indicative of pronation‐supination movements; the well‐developed lateral epicondylar ridge and the medially protruding entepicondyle are in agreement with an important development of the brachioradialis, supinator, flexor digitorum profundus, and pronator teres muscles, acting in climbing and grasping functions; the mechanical advantage of the biceps brachii would be emphasized because of its distal attachment on the bicipital tuberosity. As with extant porcupines, in Miocene species, the large femoral head would have permitted a broad range of abduction of the femur, and the medially protruding lesser trochanter would have emphasized the abduction and outward rotation of the femur by the action of the ilio‐psoas complex. In S. duplicatus, the shape of the hip, knee, and cruro‐astragalar, calcaneo‐astragalar, and astragalo‐navicular joints would have allowed lateral and rotational movements, although probably to a lesser degree than in extant porcupines. Foot features of S. duplicatus (e.g., great medial sesamoid bone, medial astragalar head, complete hallux) indicate that this species would have had grasping ability, but would not have achieved the high degree of specialization of Coendou. Steiromys duplicatus would have been a semiarboreal dweller, resembling Erethizon dorsatum. J. Morphol., 2008. © 2007 Wiley‐Liss, Inc.
Double common bile duct: Curved‐planar reformatted computed tomography (CT) and gadobenate dimeglumine–enhanced MR cholangiography
Authors: Park Mi‐Suk , Kim Byung Chang , Kim Tae il , Kim Myeong‐Jin , Kim Ki Whang 
Published: December 2007

AbstractWe present the case of a 61‐year‐old female with double common bile duct (CBD) with an opening into the lesser curvature of the stomach. We discuss the role of curved‐planar reformatted computed tomography (CT) and gadobenate dimeglumine (Gd‐BOPTA)–enhanced T1‐weighted MRI in confirming the diagnosis of this uncommon disease. J. Magn. Reson. Imaging 2008;29:209–211. © 2007 Wiley‐Liss, Inc.
Anger, hostility, and aggression among Iraq and Afghanistan war veterans reporting PTSD and subthreshold PTSD
Authors: Jakupcak Matthew , Conybeare Daniel , Phelps Lori , Hunt Stephen , Holmes Hollie A. , Felker Bradford , Klevens Michele , McFall Miles E. 
Published: December 2007

AbstractIraq and Afghanistan War veterans were grouped by level of posttraumatic stress disorder (PTSD) symptomatology and compared on self‐report measures of trait anger, hostility, and aggression. Veterans who screened positive for PTSD reported significantly greater anger and hostility than those in the subthreshold‐PTSD and non‐PTSD groups. Veterans in the subthreshold‐PTSD group reported significantly greater anger and hostility than those in the non‐PTSD group. The PTSD and subthreshold‐PTSD groups did not differ with respect to aggression, though both groups were significantly more likely to have endorsed aggression than the non‐PTSD group. These findings suggest that providers should screen for anger and aggression among Iraq and Afghanistan War veterans who exhibit symptoms of PTSD and incorporate relevant anger treatments into early intervention strategies.