bluuebunny/crossref_metadata_2025_split huggingface dataset:
Randomized clinical trial of groin hernia repair with titanium-coated lightweight mesh compared with standard polypropylene mesh
Authors: Koch A , Bringman S , Myrelid P , Smeds S , Kald A 
Published: September 2008

Abstract

Background
Groin hernia repair is one of the commonest operations in general surgery. Existing techniques have very low and acceptable recurrence rates, but chronic pain and discomfort remain a problem for many patients. New mesh materials are being developed to increase biocompatibility, and the aim of this study was to compare a new titanium-coated lightweight mesh with a standard polypropylene mesh.

Methods
A randomized controlled single-centre clinical trial was designed, with the basic principle of one unit, one surgeon, one technique (Lichtenstein under general anaesthesia) and two meshes. Pain before and after surgery, and during convalescence (primary outcomes) was estimated in 317 patients. At 1-year clinical follow-up, recurrence, pain, discomfort and quality of life (secondary outcomes) were evaluated.

Results
Patients with the lightweight mesh returned to work after 4 days, compared with 6·5 days for the standard mesh (P = 0·040). The lightweight group returned to normal activity after 7 days, versus 10 days for the standard group (P = 0·005). There was no difference in postoperative pain or recurrence at the 1-year follow-up.

Conclusion
Patients with the lightweight mesh had a shorter convalescence than those with the standard heavyweight mesh. Registration number: ISRCTN36979348 (http://www.controlled-trials.com).
Health-related quality of life in patients treated for enterocutaneous fistula
Authors: Visschers R G J , Damink S W M Olde , van Bekkum M , Winkens B , Soeters P B , van Gemert W G 
Published: September 2008

Abstract

Background
Patients with enterocutaneous fistulas undergo long intensive treatment. The aim of this study was to investigate the long-term health-related quality of life (HRQL) of these patients.

Methods
Consecutive patients treated for enterocutaneous fistula between 1990 and 2005 were eligible for this retrospective study. The Karnofsky Performance Scale (KPS), Short Form 36 (SF-36®) and the Inflammatory Bowel Disease Questionnaire were used to measure HRQL. The SF-36® was matched with results from healthy controls. Patients also gave information on concurrent medical illnesses.

Results
Of 135 patients, 44 died, 14 were lost to follow-up and 12 refused to participate; of the remaining 65, 62 participated (response rate 81 per cent). HRQL was independent of patient characteristics during treatment. Scores for SF-36® domains were lower than in their matched controls (P &lt; 0·050). Concurrent medical illness (cancer, depression and gastrointestinal disease) significantly reduced HRQL (for example with a 40 per cent reduction in vitality). The median KPS score was 80, indicating that activities could be performed with effort and patients had some signs of disease.

Conclusion
HRQL is lower in patients treated for enterocutaneous fistula than in matched controls, particularly in those with concurrent medical illnesses. Patients treated successfully have normal independence in daily functioning.
Randomized clinical trial comparing endovenous laser with cryostripping for great saphenous varicose veins
Authors: Disselhoff B C V M , der Kinderen D J , Kelder J C , Moll F L 
Published: September 2008

Abstract

Background
The aim of this randomized single-centre trial was to compare the 2-year results of endovenous laser ablation (EVLA) and cryostripping for varicose veins.

Methods
A total of 120 patients with uncomplicated great saphenous varicose veins were randomized equally to one of the two treatments. Principal outcomes measures were: freedom from recurrent varicose veins on duplex imaging, and improvement in Venous Clinical Severity Score (VCSS) and Aberdeen Varicose Vein Severity Score (AVVSS) 6, 12 and 24 months after treatment.

Results
Life-table analysis showed overall freedom from recurrent incompetence at 2 years in 77 (95 per cent confidence interval (c.i.) 72 to 78) per cent of patients after EVLA and in 66 (95 per cent c.i. 60 to 67) per cent after cryostripping (P = 0·253). VCSS and AVVSS values improved significantly after treatment, but the differences between the treatments were not significant. EVLA provided significantly more favourable results than cryostripping with respect to duration of operation, postprocedural pain, induration and resumption of normal activity.

Conclusion
EVLA and cryostripping were similarly effective in patients with varicose veins, but patients favoured EVLA because of less pain and postoperative morbidity, and quicker return to normal activity. Registration number: ISRCTN33832691 (http://www.controlled-trials.com).
Vicarious and post‐memory practices in adopting families: The re‐production of the past through photography and narrative
Authors: Brookfield Helen , Brown Steven D. , Reavey Paula 
Published: September 2008

AbstractIn this paper, we explore how adoptive parents manage and order visual information relating to their adoptive child's birth or foster family. More specifically, our task is to make sense of the ways in which the memories that children have of their past families are (re)constructed and managed within the context of present adoptive parental concerns. Life story books have become a dominant way in which narratives of the child's past family are formed. The aim of this book is to provide the child with relevant information, objects, possessions and images of the past and to create a coherent narrative between the past and the present. Parents are encouraged to make use of visual images, consisting mainly of photographs of birth families and foster carers to order the autobiography of the child. To date, there is no research that has examined how the process is experienced by parents and children. In order to examine how parents made use of visual information in particular, we carried out two focus groups with adoptive parents who participated in an adoption agency support group. A social remembering approach informed the questions asked, and a discursive analysis of the data was developed. The main analytical focus in this paper is on how photographs, objects and places serve as active participants in the production of the adoptive children's memory. Copyright © 2008 John Wiley & Sons, Ltd.
But‐3‐ene‐1,2‐diol: A Mechanism‐Based Active Site Inhibitor for Coenzyme B12‐Dependent Glycerol Dehydratase
Authors: Pierik Antonio J. , Graf Torsten , Pemberton Louise , Golding Bernard T. , Rétey János 
Published: September 2008

AbstractCoenzyme B12‐dependent glycerol dehydratase is a radical enzyme that catalyses the conversion of glycerol into 3‐hydroxypropanal and propane‐1,2‐diol into propanal via enzyme‐bound intermediate radicals. The substrate analogue but‐3‐ene‐1,2‐diol was studied in the expectation that it would lead to the 4,4‐dihydroxylbut‐2‐en‐1‐yl radical, which is stabilised (allylic) and not reactive enough to retrieve a hydrogen atom from 5′‐deoxyadenosine, thereby interrupting the catalytic cycle. Racemic and enantiomerically pure but‐3‐ene‐1,2‐diols and their [1,1‐2H2], [2‐2H] and [4,4‐2H2] isotopomers were synthesised and characterised by NMR spectroscopy. (S)‐[4‐14C]but‐3‐ene‐1,2‐diol was also prepared. Kinetic measurements showed but‐3‐ene‐1,2‐diol to be a competitive inhibitor of glycerol dehydratase (Ki=0.21 mM, ki=5.0×10−2 s−1). With [4‐14C]but‐3‐ene‐1,2‐diol it was demonstrated that species derived from the diol become tightly bound to the enzyme's active site, but not covalently bound, because the radioactivity could be removed upon denaturation of the enzyme. EPR measurements with propane‐1,2‐diol as substrate generated sharp signals after 10 s that disappeared after about 1 min. In contrast, EPR resonances appeared and disappeared more slowly when but‐3‐ene‐1,2‐diol was incubated with the enzyme. Among the deuterated isotopomers, only [1,1‐2H2]but‐3‐ene‐1,2‐diol showed a significantly different EPR spectrum from that of the unlabelled diol; this indicated that coupling between the unpaired electron and a deuterium at C‐1 was stronger than with deuterium at C‐2 or C‐4. The experiments suggest the formation of the 1,2‐dihydroxybut‐3‐en‐1‐yl radical, which decomposes to unidentified product(s).
Synthesis and Conformational Analysis of Stevastelin C3 Analogues and Their Activity Against the Dual‐Specific Vaccina H1‐Related Phosphatase
Authors: Bisek Nicola , Wetzel Stefan , Arndt Hans‐Dieter , Waldmann Herbert 
Published: September 2008

AbstractThe biological activity of macrocyclic natural products depends on their conformational properties. For both the elucidation of enzyme binding affinities as well as the development of selective drugs, rigid macrocyclic scaffolds carry high potential. In this study, 13‐membered cyclodepsipeptides based on the structure of naturally occurring stevastelins were studied in detail. Six diastereomeric stevastelin C3 analogues and four phosphorylated derivatives were synthesized. The synthesis of linear precursors was achieved on solid support by starting from stereoisomerically pure 2‐methyl‐3‐hydroxy acids. Subsequent macro‐lactamization gave the cyclic depsipeptides in very good yields (36–62 %). The conformational space of these stevastelin C3 analogues was computationally investigated. On the basis of NMR spectroscopic data, homogeneous conformations were determined for each benzylated depsipeptide and the influence of phosphorylation on the overall conformation was investigated. Importantly, phosphorylation was found to significantly weaken the conformational preferences of the 13‐membered depsipeptides. Finally, the cyclic depsipeptides were tested for activity against phosphatases. Inhibitory activity on vaccina H1‐related phosphatase was observed depending on the derivatization of the cycles. The activity profiles are discussed in the light of the structural data.
Organocatalytic Enantioselective Synthesis of Highly Functionalized Polysubstituted Pyrrolidines
Authors: Ruiz Nerea , Reyes Efraím , Vicario Jose L. , Badía Dolores , Carrillo Luisa , Uria Uxue 
Published: September 2008

AbstractThe organocatalytic conjugate addition of different aldehydes to β‐nitroacrolein dimethyl acetal, generating the corresponding highly functionalized nitroaldehydes in high yields and with high stereoselectivities, has been studied in detail. These transformations have been achieved by using both readily available starting materials in a 1:1 ratio as well as commercially available catalysts at a 10 mol % catalyst loading. Furthermore, a very short and efficient protocol has been devised for the preparation of highly enantioenriched pyrrolidines containing two or three contiguous stereocenters starting from the obtained Michael adducts. 3,4‐Disubstituted pyrrolidines have been obtained in a single step by Zn‐mediated chemoselective reduction of the nitro group followed by intramolecular reductive amination, and trisubstituted homoproline derivatives have been prepared by means of an olefination reaction and a cascade process involving chemoselective reduction of the nitro group followed by a fully diastereoselective intramolecular aza‐ Michael reaction.
Recent Advances in “Formal” Ruthenium‐Catalyzed [2+2+2] Cycloaddition Reactions of Diynes to Alkenes
Authors: García‐Rubín Silvia , Varela Jesús A. , Castedo Luis , Saá Carlos 
Published: September 2008

Abstract“Formal” and standard RuII‐catalyzed [2+2+2] cycloaddition of 1,6‐diynes to alkenes gave bicyclic 1,3‐cyclohexadienes in relatively good yields. When terminal 1,6‐diynes 1 were used, two isomeric bicyclic 1,3‐cyclohexadienes 4 or 6 were obtained, depending on the acyclic or cyclic nature of the alkene partner. When unsymmetrical substituted 1,6‐diynes 7 were used, the reaction with acyclic alkenes took place regio‐ and stereoselectively to afford bicyclic 1,3‐cyclohexadienes 8. A cascade process that behaves as a “formal” RuII‐catalyzed [2+2+2] cycloaddition explained these results. Initially, a Ru‐catalyzed linear coupling of 1,6‐diynes 1 and 7 with acyclic alkenes occurs to give open 1,3,5‐trienes of type 3, which after a thermal disrotatory 6e− π‐electrocyclization led to the final 1,3‐cyclohexadienes 4 and 8. When disubstituted 1,6‐diyne 10 was used with electron‐deficient alkenes, new exo‐methylene cyclohexadienes 12 arose from a competitive reaction pathway.
ChemInform Abstract: Crystal Structure of the Quaternary Alloy CuTaInSe3.
Authors: Delgado G. E. , Mora A. J. , Grima‐Gallardo P. , Duran S. , Munoz M. , Quintero M. 
Published: September 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Superconductivity at 43 K in SmFeAsO1‐xFx.
Authors: Chen X. H. , Wu T. , Wu G. , Liu R. H. , Chen H. Chen H. , Fang D. F. 
Published: September 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Two‐Band Superconductivity in LaFeAsO0.89F0.11 at Very High Magnetic Fields.
Authors: Hunte F. , Jaroszynski J. , Gurevich A. , Larbalestier D. C. , Jin R. , Sefat A. S. , McGuire M. A. , Sales B. C. , Christen D. K. , Mandrus D. 
Published: September 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Gold(III) Chloride‐Catalyzed Diastereoselective Alkylation Reactions with Chiral Benzylic Acetates.
Authors: Rubenbauer Philipp , Bach Thorsten 
Published: September 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Efficient Catalysis of Ullmann‐Type Arylation Reactions by a Novel Trinuclear Copper(I) Complex with a Chelating Tricarbene Ligand.
Authors: Tubaro Cristina , Biffis Andrea , Scattolin Elena , Basato Marino 
Published: September 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Efficient Base Catalyzed Alkylation Reactions with Aziridine Electrophiles.
Authors: Moss Thomas A. , Alba Aurelie , Hepworth David , Dixon Darren J. 
Published: September 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Diketones and ω‐Hydroxy Ketones from Methyl Ketones and α,ω‐Diols by an [IrCl(cod)]2/PPh3/KOH System.
Authors: Maeda Kensaku , Obora Yasushi , Sakaguchi Satoshi , Ishii Yasutaka 
Published: September 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Effective Amidation of Carboxylic Acids Using (4,5‐Dichloro‐6‐oxo‐6H‐pyridazin‐1‐yl)phosphoric Acid Diethyl Ester.
Authors: Kang Seung‐Beom , Yim Heung‐Seop , Won Ju‐Eun , Kim Min‐Jung , Kim Jeum‐Jong , Kim Ho‐Kyun , Lee Sang‐Gyeong , Yoon Yong‐Jin 
Published: September 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Chemoselective and Efficient Method for Deprotection of THP and Silyl Ethers with H2O2/Mn(III) Schiff‐Base Complex.
Authors: Tajbakhsh Mahmood , Hosseinzadeh Rahman , Golchoubian Hamid , Razavian Raheleh 
Published: September 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Stereoselective Nickel‐Catalyzed Cycloisomerization of 1,6‐Dienes.
Authors: Boeing Christian , Hahne Julia , Francio Giancarlo , Leitner Walter 
Published: September 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Direct Allylation of Aldimines Catalyzed by C2‐Symmetric N,N′‐Dioxide‐Sc(III) Complexes: Highly Enantioselective Synthesis of Homoallylic Amines.
Authors: Li Xing , Liu Xiaohua , Fu Yingzi , Wang Lijia , Zhou Lin , Feng Xiaoming 
Published: September 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Stereoselective Synthesis of β,γ‐Unsaturated Ketones by Acid‐Mediated Julia‐Type Transformation from 2‐(1‐Hydroxyalkyl)‐1‐alkylcyclopropanols.
Authors: Nomura Kenichi , Matsubara Seijiro 
Published: September 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Diastereo‐ and Enantioselective Synthesis of α‐Substituted syn‐α,β‐Diamino Acids.
Authors: Singh Anand , Johnston Jeffrey N. 
Published: September 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Regioselective Markovnikov Hydrochalcogenation of Terminal Alkynes with Indium(III) Benzenechalcogenolates.
Authors: Peppe Clovis , de Castro Lierson Borges , Mello Melina de Azevedo , Barros Olga Soares do Rego 
Published: September 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Arenium Cation as the Key Intermediate of the Electrosynthesis of N‐(2,5‐Dimethoxyphenyl)azoles. A New Approach to the Synthesis of N‐(Dimethoxyphenyl)azoles.
Authors: Petrosyan V. A. , Burasov A. V. 
Published: September 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: 2,5‐Dimethoxy‐2,5‐dihydrofuran Chemistry: A New Approach to 2(5H)‐Furanone Derivatives.
Authors: Garzelli R. , Samaritani S. , Malanga C. 
Published: September 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Facile Formation of Tetrahydrofurans with Multiple Chiral Centers Using Double Iodoetherification of σ‐Symmetric Diene Acetals: Short Asymmetric Total Synthesis of Rubrenolide (VIII) and Rubrynolide (IX).
Authors: Fujioka Hiromichi , Ohba Yusuke , Hirose Hideki , Nakahara Kenji , Murai Kenichi , Kita Yasuyuki 
Published: September 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Regioselective Reductive Opening of Substituted Phthalans: Synthetic Applications.
Authors: Garcia Daniel , Foubelo Francisco , Yus Miguel 
Published: September 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of 6‐Oxacyclopropa[a]indene Derivatives Starting from Baylis—Hillman Adducts via Pd‐Mediated C(sp3)—H Activation.
Authors: Kim Hoo Sook , Gowrisankar Saravanan , Kim Sung Hwan , Kim Jae Nyoung 
Published: September 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Functionalized 5‐Oxo‐2,5‐dihydro‐1H‐pyrroles from Primary Alkylamines, Oxalyl Chloride, and Dimethyl Acetylenedicarboxylate.
Authors: Yavari Issa , Souri Sanaz 
Published: September 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Polysubstituted Pyrroles from Sulfinimines (N‐Sulfinyl Imines).
Authors: Davis Franklin A. , Bowen Kerisha A. , Xu He , Velvadapu Venkata 
Published: September 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.