bluuebunny/crossref_metadata_2025_split huggingface dataset:
A practice‐based study of relational virtues and alliance correspondence in psychodynamic psychotherapy
Authors: Jankowski Peter J. , Sandage Steven J. , Captari Laura E. , Crabtree Sarah A. , Choe Elise J. , Gerstenblith Judy 
Published: February 2024

AbstractObjectiveTreatment outcome monitoring typically emphasizes pathology. In contrast, we responded to the need to establish psychodynamic psychotherapy as evidence‐based by modeling changes in gratitude and forgiveness.MethodWe utilized a practice‐based research design involving non‐manualized outpatient treatment. We employed a longitudinal mixture modeling approach to evaluate treatment effectiveness. We did so by testing the theorized role for relational virtues (i.e., gratitude, forgiveness) as signs of progress in psychodynamic treatment, with relational virtues referring to the application of character strengths to specific situations. We modeled clients' self‐reported level on the virtues as a joint process over five time points, and examined the influence of early treatment alliance correspondence on patterns of change using a sample of outpatient clients (N = 185; Mage = 40.12; 60% female; 74.1% White).ResultsA 3‐class solution best fit the data, with one class exhibiting growth in gratitude and forgiveness, improved symptoms, and a greater likelihood of symptom improvement relative to well‐being gains. Alliance correspondence predicted the classes of change patterns, with greater similarity between clinicians' and clients' perceptions about the alliance predicting greater likelihood of belonging to the subgroup showing highest levels of virtues and well‐being, lowest symptoms, and improved well‐being.ConclusionClinical implications involve monitoring gratitude and forgiveness as signs of progress and navigating the dialectic between implicit alliance processes and explicit virtue interventions. The former involves nurturing a strong alliance and repairing ruptures, whereas the latter involves direct in‐session conversation and/or the practice of virtue interventions in and/or outside of session.
Bifactor models of psychopathology using multi‐informant and multi‐instrument dimensional measures in the ABCD study
Authors: Jacobs Grace R. , Ameis Stephanie H. , Szatmari Peter , Haltigan John D. , Voineskos Aristotle N. 
Published: February 2024

AbstractBackgroundDue to limitations of categorical definitions of mental illness, there is a need for quantitative empirical investigations of the dimensional structure of psychopathology. Using exploratory bifactor methods, this study investigated a comprehensive and representative structure of psychopathology in children to better understand how psychotic‐like experiences (PLEs), autism spectrum disorder (ASD) symptoms, impulsivity, and sensitivity to reward and punishment, may be integrated into extant general factor models of psychopathology.MethodsWe used seven child‐report and three parent‐report instruments capturing diverse mental health symptoms in 11,185 children aged 9–10 from the Adolescent Brain Cognitive DevelopmentSM (ABCD) Study. We built on previous modeling frameworks by conducting both split sample and full sample factor analytic approaches that harnessed recent methodological advances in bifactor exploratory structural equation modeling (B‐ESEM) to examine a wide range of psychopathology measures not previously integrated into a single analysis. Validity of psychopathology dimensions was examined by investigating associations with sex, age, cognition, imaging measures, and medical service usage.ResultsAll four factor analytic models showed excellent fit and similar structure within informant. PLEs loaded most highly onto a general psychopathology factor, suggesting that they may reflect non‐specific risk for mental illness. ASD symptoms loaded separately from attention/hyperactivity symptoms. Symptoms of impulsivity and sensitivity to reward and punishment loaded onto specific factors, distinct from externalizing and internalizing factors. All identified factors were associated with clinically relevant risk factors, providing preliminary evidence for their construct validity.ConclusionBy integrating diverse child‐report and parent‐report psychopathology measures for children in the ABCD sample, we deliver data on the quantitative structure of psychopathology for an exceptionally large set of measurements and discuss implications for the field.
Global analysis of urinary extracellular vesicle small RNAs in autosomal dominant polycystic kidney disease
Authors: Ali Hamad , Malik Md. Zubbair , Abu‐Farha Mohamed , Abubaker Jehad , Cherian Preethi , Nizam Rasheeba , Jacob Sindhu , Bahbahani Yousif , Naim Medhat , Ahmad Sajjad , Al‐Sayegh Mohammad , Thanaraj Thangavel Alphonse , Ong Albert C. M. , Harris Peter C. , Al‐Mulla Fahd 
Published: February 2024

AbstractBackgroundAutosomal dominant polycystic kidney disease (ADPKD) is the most prevalent monogenic renal disease progressing to end‐stage renal disease. There is a pressing need for the identification of early ADPKD biomarkers to enable timely intervention and the development of effective therapeutic approaches. Here, we profiled human urinary extracellular vesicles small RNAs by small RNA sequencing in patients with ADPKD and compared their differential expression considering healthy control individuals to identify dysregulated small RNAs and analyze downstream interaction to gain insight about molecular pathophysiology.MethodsThis is a cross‐sectional study where urine samples were collected from a total of 23 PKD1‐ADPKD patients and 28 healthy individuals. Urinary extracellular vesicles were purified, and small RNA was isolated and sequenced. Differentially expressed Small RNA were identified and functional enrichment analysis of the critical miRNAs was performed to identify driver genes and affected pathways.ResultsmiR‐320b, miR‐320c, miR‐146a‐5p, miR‐199b‐3p, miR‐671‐5p, miR‐1246, miR‐8485, miR‐3656, has_piR_020497, has_piR_020496 and has_piR_016271 were significantly upregulated in ADPKD patient urine extracellular vesicles and miRNA‐29c was significantly downregulated. Five ‘driver’ target genes (FBRS, EDC3, FMNL3, CTNNBIP1 and KMT2A) were identified.ConclusionsThe findings of the present study make significant contributions to the understanding of ADPKD pathogenesis and to the identification of novel biomarkers and potential drug targets aimed at slowing disease progression in ADPKD.
Operative trends following the adoption of nonoperative management of rectal cancer
Authors: Brewer Justin , Kamara Maseray , Huebner Marianne , Taxakis Elias , Grajewski Karen , Ramm Carole , Cleary Robert K. 
Published: February 2024

AbstractBackgroundDifferentiating clinical near‐complete and complete responses (cCR) after neoadjuvant therapy (NT) is challenging in rectal cancer patients. We hypothesized that magnetic resonance imaging staging limitations for low rectal cancers may increase the proportion of abdominoperineal resection (APR) with permanent colostomy for those without a cCR.MethodsSingle institution retrospective analysis of rectal cancer cases before and after adoption of nonoperative “watch and wait” (W&W) pathway. APR as a percentage of rectal resections was the primary outcome.ResultsThere were 76 total mesorectal excisions (TME) in the pre‐W&W group and 98 in the post‐W&W group. NT was significantly more common in the post‐W&W group. There was no significant difference in the APR primary outcome (pre‐W&W APR 33.3% vs. post‐W&W APR 26.5%, p = 0.482). APR patients had fewer complete TME grades (69.2% vs. 46.2%) and more pathologic complete responses (0% vs. 26.9%) in the post‐W&W period. The cCR rate for patients with nonoperative management was 51.4% (n = 37) and 13.5% (n = 5) had regrowths, all of whom underwent salvage surgery.ConclusionAPR for those without a cCR to NT has not increased in the nonoperative management era. Balancing the pathologic complete response rate may require restaging some patients with clinical near‐complete responses.
Microbial diversity drives soil multifunctionality along reclamation chronosequence in an opencast coal mine
Authors: Xu Caicai , Zhang Hong , Li Junjian , Liu Yong , Su Chao 
Published: February 2024

AbstractPlantation reclamation can improve soil microbial diversity and soil multifunctionality in the reclaimed coal mine. However, with the reclamation years, how restoration of microbial communities promotes restoration of soil multifunctionality is not clear. Here, we investigated the microbial diversity and soil physicochemical properties and soil enzyme activities of different reclamation years in the reclaimed coal mine afforested with Chinese pine (Pinus tabuliformis). We chose six soil physicochemical properties (soil BD, pH, TC, TN, soil labile carbon [LC1], and [LC2]) pools and four soil enzyme activities (invertase, dehydrogenase, polyphenol oxidase, and urease) as soil multifunctionality indicators. Firstly, we compared the difference of soil microbial alpha diversity and soil physicochemical properties and soil enzyme activities of the different reclamation years and studied the changes of soil multifunctionality with the reclamation years. Secondly, the relationship between soil microbial diversity and soil multifunctionality was compared by fitting five different functions (logarithmic, linear, M‐M, power, and exponential). Thirdly, we analyzed the driving effects of soil microbial diversity on soil multifunctionality at different threshold levels. Finally, the important driving factors on soil multifunctionality were explored. The results confirmed there were significant differences in soil microbial alpha diversity of different reclamation years, and the later stage was significantly higher than the initial stage of reclamation. Soil multifunctionality increased significantly with the reclamation years, and the soil multifunctionality related to carbon and nitrogen cycle increased more significantly. Microbial communities have strong driving effects on soil multifunctionality. Bacterial diversity was positively correlated with soil carbon cycle and nitrogen cycle function and soil multifunctionality in a nonredundant fashion. Random forest and structural equation modeling analyses showed that bacterial diversity was the most important biotic factor. Reclamation years had indirect effects on soil multifunctionality by affecting microbial communities. Soil microbial diversity had strong driving effects on soil multifunctionality. The results provided empirical evidence that the protection of biodiversity is crucial for maintaining ecosystem functions in reclaimed coal mine ecosystem.
Novel variants in TNRC6B cause global developmental delay with speech and behavioral abnormalities, short stature, low body weight, café‐au‐lait spots, and metabolic abnormality
Authors: Yang Qi , Ou Shan , Zhou Xunzhao , Yi Sheng , Lin Li , Yi Shang , Zhang Shujie , Qin Zailong , Luo Jingsi 
Published: February 2024

AbstractBackgroundTNRC6B deficiency syndrome, also known as global developmental delay with speech and behavioral abnormalities (MIM 619243), is a rare autosomal dominant genetic disease mainly characterized by facial dysmorphism, developmental delay/intellectual disability (DD/ID), speech and language delay, fine and motor delay, attention deficit and hyperactivity disorder (ADHD), and variable behavioral abnormalities. It is caused by heterozygous variant in the TNRC6B gene (NM_001162501.2, MIM 610740), which encodes the trinucleotide repeat‐containing adaptor 6B protein.MethodsIn this study, two Chinese patients with TNRC6B deficiency syndrome were recruited, and genomic DNA extraction from peripheral blood leukocytes of these parents and their family members was extracted for whole‐exome sequencing and Sanger sequencing.ResultsHere, we report two unrelated Chinese patients diagnosed with TNRC6B deficiency syndrome caused by novel de novo likely pathogenic or pathogenic TNRC6B variants c.335C>T (p.Pro112Leu) and c.1632delC (p.Leu546fs*63), which expands the genetic spectrum of TNRC6B deficiency syndrome. The clinical features of the patients were DD/ID, delayed speech, ADHD, behavioral abnormalities, short stature, low body weight, café‐au‐lait spots, metabolic abnormalities, and facial dysmorphism including coarse facial features, sparse hair, frontal bossing, hypertelorism, amblyopia, strabismus, and downslanted palpebral fissures, which expands the phenotype spectrum associated with TNRC6B deficiency syndrome.ConclusionThis study expands the genotypic and phenotypic spectrum of TNRC6B deficiency syndrome. Our findings indicate that patients with TNRC6B deficiency syndrome should be monitored for growth and metabolic problems and therapeutic strategies should be developed to address these problems. Our report also suggests the clinical diversity of TNRC6B deficiency syndrome.
Technical note: TIGRE‐DE for the creation of virtual monoenergetic images from dual‐energy cone‐beam CT
Authors: Keeler Andrew , Lehmann Mathias , Luce Jason , Kaur Mandeep , Roeske John , Kang Hyejoo 
Published: February 2024

AbstractBackgroundDual‐energy (DE)‐CBCT represents a promising imaging modality that can produce virtual monoenergetic (VM) CBCT images. VM images, which provide enhanced contrast and reduced imaging artifacts, can be used to assist in soft‐tissue visualization during image‐guided radiotherapy.PurposeThis work reports the development of TIGRE‐DE, a module in the open‐source TIGRE toolkit for the performance of DE‐CBCT and the production of VM CBCT images. This module is created to make DE‐CBCT tools accessible in a wider range of clinical and research settings.MethodsWe developed an add‐on (TIGRE‐DE) to the TIGRE toolkit that performs DE material decomposition. To verify its performance, sequential CBCT scans at 80 and 140 kV of a Catphan 604 phantom were decomposed into equivalent thicknesses of aluminum (Al) and polymethyl‐methylacrylate (PMMA) basis materials. These basis material projections were used to synthesize VM projections for a range of x‐ray energies, which were then reconstructed using the Feldkamp‐Davis‐Kress (FDK) algorithm. Image quality was assessed by computing Hounsfield units (HU) and contrast‐to‐noise ratios (CNR) for the material inserts of the phantom and comparing with the constituent 80 and 140 kV images.ResultsAll VM images generated using TIGRE‐DE showed good general agreement with the theoretical HU values of the material inserts of the phantom. Apart from the highest‐density inserts imaged at the extremes of the energy range, the measured HU values agree with theoretical HUs within the clinical tolerance of ±50 HU. CNR measurements for the various inserts showed that, of the energies selected, 60 keV provided the highest CNR values. Moreover, 60 keV VM images showed average CNR enhancements of 63% and 66% compared to the 80 and 140 kV full‐fan protocols.ConclusionsTIGRE‐DE successfully implements DE‐CBCT material decomposition and VM image creation in an accessible, open‐source platform.
Greenery hypothesis: An evolutionary explanation for why presence/absence of green affects humans
Authors: Fukano Yuya , Soga Masashi 
Published: February 2024

Abstract

A growing body of empirical evidence shows that experiences of nature provide people with diverse psychological benefits, including improved cognitive function and mental health. While our understanding of the proximate causes of these positive psychological responses of humans to nature has advanced, the ultimate (evolutionary) drivers behind them remain poorly understood.

In this study, we provide a summary of several widely accepted evolutionary hypotheses originating from Biophilia, reviewing their challenges and limitations. Subsequently, we propose a new evolutionary psychological hypothesis—the greenery hypothesis—that integrates recent findings in evolutionary psychiatry with many experimental results unexplained by existing hypotheses/theories.

Our proposed hypothesis states that humans have adapted to periodic severe drought and re‐watering cycles by developing both negative and positive psychological responses to the absence or presence of greenery within the landscape as cues to optimise their own behavioural activity.

The greenery hypothesis holds the potential to yield several insights into the fundamental understanding of human psychological responses to nature exposure with significant implications for various related fields, including psychiatry, urban planning, and biodiversity conservation and restoration.

Read the free Plain Language Summary for this article on the Journal blog.
Effect of polydiborosiloxane on the mechanical properties of silicone rubber foam with dual network structure
Authors: Ma Xinguo , Luo Chao , Zeng Hongwen , Peng Yan , Zhao Lijuan , Zhang Fengshun 
Published: February 2024

AbstractA silicone rubber foam is prepared by introducing polydiborosiloxane (PDBS) into silicone rubber, and using expandable microspheres as blowing agents. The influences of the dual network structure with dynamic cross‐linking network on the silicone rubber foam is characterized by the cell size, mechanical properties and impact resistance. The cell size increases from 77 to 93 μm due to the introduction of a dynamic cross‐linking network which reduces foaming resistance. The elongation at break elevates from 277% to 574%, and the yield strength gradually decreases. The dynamic cross‐linking network also enhances the internal damping characteristic and energy absorption capacity of the foam. The impact resistance of silicone rubber foam is improved because of the synergistic effect of the dual network structure and the bubble structure. The research improves the performance of silicone rubber foam.
Studies on graphene oxide modified corn oil‐based polyester‐urea nanocomposite coating for anticorrosive application
Authors: Alam Manawwer , Wahab Rizwan , Ahmed Mukhtar , Altaf Mohammad 
Published: February 2024

AbstractPolyester‐urea coatings were synthesized from corn oil with the help of a series of reactions in three different compositions by varying the amount of urea. Out of all the synthesized compositions, the best composition was optimized based on various parameters. The optimized composition was used as a matrix and graphene oxide (GO) was incorporated in three ratios, for the formulation of corn oil‐based CPEUr@GO nanocomposites. Fourier transform infrared spectroscopy was used to confirm all the reactions. The physico‐mechanical properties of CPEUr2 coating were found to be the best among all the compositions. Therefore, CPEUr2 was selected as a matrix for the inclusion of GO nanosheets to prepare CPEUr2@GO nanocomposites. Thermogravimetric analysis results showed that incorporation of GO enhanced the thermal stability of CPEUr2 up to 325°C. The anticorrosive studies revealed the high impedance value of 6.5 × 105 Ω.cm2 in case of CPEUr2@GO0.5. Furthermore, it can be concluded that the inclusion of 0.5 wt% GO proved to be the optimized amount to produce sustainable CPEUr2 coatings with good performance. These CPEUr@GO nanocomposite coatings can be used for various protective purposes owing to their excellent physico‐mechanical thermal as well as anticorrosive performance.Highlights
Corn oil‐based polyester‐urea, CPEUr, coatings were synthesized in three different compositions.
The best composition was used as a matrix for the formulation of CPEUr@GO nanocomposites.
Graphene oxide of 0.5 wt% was found to be the optimum quantity required to modify CPEUr matrix.
Thermal stability, mechanical durability as well as corrosion resistance performances were enhanced.
The environment friendly approach is suitable for the development of corrosion protective coatings.
Polymer/iron oxide nanocomposites as magnetic resonance imaging contrast agents: Polymer modulation and probe property control
Authors: Gu Haojie , Fu Shengxiang , Cai Zhongyuan , Ai Hua 
Published: February 2024

AbstractSuperparamagnetic iron oxide nanoparticles (SPIONs) are commonly used as magnetic resonance imaging (MRI) probes/contrast agents in clinical diagnosis because they can significantly improve the sensitivity of MRI. Polymers including natural and synthetic polymers with good biosafety and abundant surface groups are ideal surface coating for SPIONs to overcome their drawbacks such as poor colloidal stability, low relaxivity, and lack of functionality. Several SPIONs' structural properties such as crystal shape and size, charge, shell thickness, and cluster determine their relaxivity, biosafety, and in vivo imaging effect. Therefore, the rational design of SPIONs probes must explore the relationship between polymer structure and SPION properties. In this review, key structural properties of polymers such as surface groups, molecular weight, hydrophilicity, and grafting density are discussed for their effects on key properties of SPIONs. Additionally, some special polysaccharides, polypeptides, and antibodies can be used as targeting molecules to improve the imaging specificity of SPIONs, which is also briefly discussed in this review.
Design of new zwitterionic microparticles with intrinsic antibacterial activity
Authors: Trofin Marin‐Aurel , Racovita Stefania , Avadanei Mihaela Iuliana , Stoica Iuliana , Rosca Irina , Vasiliu Ana‐Lavinia , Mihai Marcela , Vasiliu Silvia 
Published: February 2024

AbstractThe crosslinked porous microparticles based on glycidyl methacrylate, N‐vinylimidazole, and triethylene glycol dimethacrylate (molar ratio between monomers 40:30:30) obtained in the presence of three porogenic agents (toluene, n‐butyl acetate, and toluene:n‐butyl acetate mixture, 1:1, v/v) are used as precursors in the polymer analogous reactions with some betainizing agents (sodium monochloroacetate, acrylic acid, methacrylic acid and 1,3–propane sultone) in order to introduce the carboxybetaine/sulfobetaine groups to the tertiary nitrogen atom from the imidazole ring. ATR–FTIR spectroscopy is used to highlight the presence of carboxybetaine/sulfobetaine groups on the structure of the microparticles, but also to calculate the degree of betainization (55.91%–90.2%) The zwitterionic microparticles are characterized by scanning electron and atomic force microscopies, equilibrium swelling ratio as a function of pH values, swelling kinetics, ion exchange capacities and particle size distribution. Also, the parameters of porous structure (pore diameter, pore volume, porosity, and specific surface area) are determined by mercury porosimetry. The antibacterial properties of Gram‐positive (Enterococcus faecalis and Staphylococcus aureus) and Gram‐negative (Escherichia coli and Klebsiella pneumoniae) bacteria are evaluated. It is found that the zwitterionic structures containing a shorter length alkyl chain between ionic groups exhibit excellent antibacterial activity of about 80%–92%.