bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pudgy mouse rib deformities emanate from abnormal paravertebral longitudinal cartilage/bone accumulations
Authors: Shapiro Frederic , Wang Jamie , Flynn Evelyn , Wu Joy Y. 
Published: February 2024

ABSTRACT
The pudgy (pu/pu) mouse, caused by a recessive mutation in the Notch family Delta like-3 gene (Dll3), has severe rib, vertebral body and intervertebral disc abnormalities. Using whole-mount preparations and serial histologic sections we demonstrate: 1) localized paravertebral longitudinal cartilage/bone accumulations (PVLC/BAs) invariably associated with branched, fused and asymmetrically spaced ribs that emanate from it laterally; 2) abnormal rib formation immediately adjacent to abnormal vertebral body and intervertebral disc formation in asymmetric right/left fashion; and 3) patterns of rib deformation that differ in each mouse. Normal BALB/c embryo and age-matched non-affected pu/+ mice assessments allow for pu/pu comparisons. The Dll3 Notch family gene is involved in normal somitogenesis via the segmentation clock mechanism. Although pathogenesis of rib deformation is initially triggered by the Dll3 gene mutation, these findings of abnormal asymmetric costo-vertebral region structure imply that differing patterns cannot be attributed to this single gene mutation alone. All findings implicate a dual mechanism of malformation: the Dll3 gene mutation leading to subtle timing differences in traveling oscillation waves of the segmentation clock and further subsequent misdirection of tissue formation by altered chemical reaction-diffusion and epigenetic landscape responses. PVLC/BAs appear as primary supramolecular structures underlying severe rib malformation associated both with time-sensitive segmentation clock mutations and subsequent reactions.
MATEMÁTICA EDUCATIVA, TRANSVERSALIDAD Y COVID–19
Authors: Cantoral Uriza Ricardo , Ríos Jarquín Wendolyne , Reyes Gasperini Daniela , Cantoral Uriza Enrique A. , Barrios Borges Eleany , Fallas Soto Rodolfo , Castillo Bárcenas David , Cantoral Farfán Emilia , Flores García Rebeca , Galo Alvarenga Selvin , Paredes Cancino Cristian , García Zaragoza Viridiana , Bonilla Solano Antonio 
Published: February 2024

Este artículo relaciona nociones de la Matemática Educativa con la transversalidad de los saberes matemáticos en situaciones de pandemia por coronavirus. Se analiza un fenómeno social en el ámbito de la salud desde una mirada académica para la construcción de diálogos sobre las implicaciones de las acciones de política pública que la población lleva a cabo. Las reflexiones propuestas dejan ver el papel que juega el pensamiento matemático en la comprensión de la situación, las medidas de carácter preventivo y los problemas que de este se deriven; todo ello conlleva a la consideración de la noción de aula extendida. Así, el desarrollo del pensamiento habrá de entenderse más allá que la capacidad de resolución de problemas.
Crisis management in English local government: the limits of resilience
Authors: Arrieta Tania , Davies Jonathan S. 
Published: February 2024

Research on local government in the UK during the era of austerity has shown that the decisions taken by local councils to cope with financial stresses were often narrated through the discourse of ‘resilience’, referencing their capacity to innovate and transform services, while protecting service provision in core areas. This emphasis on ‘resilience’ focused on the deployment of strategies to overcome funding challenges. However, this earlier research did not question the longer-term risks, trade-offs and negative social implications associated with such decisions, and how, even in circumstances where these practices provided some ‘breathing space’, in the longer-term they risked adding even more strain to the system as a whole.
This article fills an important research gap by considering four resilience strategies of two local authorities in England: Leicester and Nottingham. These four strategies are: savings, reserves, collaboration and investment. Applying a meso-level perspective and exploring resilience through the lens of crisis management, it asks in what ways and for whom resilience generates positive, zero and negative-sum outcomes.
This research enhances our understanding of the resilience concept by reflecting on its limitations and the risks it poses for local government. It also reveals that, while the concept of ‘resilience’ has been much criticised for normalising crises and generally operating as part of a de-politicising vocabulary, research is lacking on how the practices of resilience produce positive, zero or negative-sum outcomes.
Educar para el devenir. Desarrollo de la resiliencia generativa y la mentalidad de crecimiento en la educación primaria: estrategias y buenas prácticas basadas en el currículo actual.
Authors: Montesinos Alabau Beatriz 
Published: February 2024

Vivimos en un mundo que cambia aceleradamente. El transhumanismo o post humanismo, la posverdad, el auge de la inteligencia artificial, la crisis climática, etc.…, nos sitúan en un momento clave de la historia de la humanidad, con grandes desafíos y cambios complejos que no pueden ser abordados de una forma simplista.
Ante este panorama, desde el ámbito educativo, no sabemos hacia dónde nos dirigimos exactamente, pero si hay algo por lo que podemos seguir abogando es por cuidar y cultivar en las aulas el tipo de personas y personalidades que puedan abordar estos cambios de la mejor manera posible.
La etapa de educación primaria, junto con la etapa de educación infantil, conforman la base sobre la que se sustentan los cimientos de las personas que llegarán a ser los alumnos. Además de las destrezas y competencias instrumentales básicas que componen los currículos de estas etapas, son claves también un adecuado desarrollo socioemocional, una correcta maduración del autoconcepto y de la autoestima, así como la motivación hacia el aprendizaje a lo largo de toda la vida.
El propósito de este artículo es desarrollar una propuesta pedagógica que incluya la resiliencia generativa y la mentalidad de crecimiento como elementos vertebradores de las competencias personales y sociales que deben adquirir los alumnos.
Esta propuesta se basa científicamente en aquellos aspectos que la neurociencia y la psicología han aportado en los últimos años acerca del funcionamiento de nuestro cerebro. Además, curricularmente se fundamenta en los descriptores operativos de las competencias clave que definen el perfil de salida del alumnado cuando finaliza la etapa de educación primaria, tal y como se recoge en el RD 157/2022 de 1 de marzo, por el que se establecen la ordenación y las enseñanzas mínimas de la Educación Primaria.
Tras el marco teórico que justifica la propuesta se presenta la base curricular de la misma, y como experiencia didáctica se proponen una serie de estrategias educativas para implementarla, así como un ejemplo concreto de programación de aula a partir de una situación de aprendizaje transversal para un nivel de 6º de primaria.
Osteoporosis and its associated factors among patients attending Manakamana Hospital, Chitwan, Nepal
Authors: Dhakal Shankar , Sharma Kalpana , Adhikari Kishor , Joshi Alisha , Poudyal Sunita 
Published: February 2024

Background
Osteoporosis is the most common skeletal disorder that weakens bones and increases their susceptibility to fractures. It is becoming an urgent and serious global epidemic. Early diagnosis and treatment are essential to reduce morbidity and mortality associated with it. This study aimed to find out the prevalence of osteoporosis among patients attending at Manakamana Hospital, Bharatpur, Chitwan, Nepal.

Methods
A cross-sectional study was adopted and 623 patients attending at orthopaedic outpatients department (OPD) of Manakamana Hospital were selected using non-probability consecutive sampling technique. Data were collected from 15th October 2021 to 15th April, 2022, by using interview schedule, chart review and Bone Mineral Density (BMD) measurement through calcaneal ultrasonography. Ethical approval was obtained from Nepal Health Research Council Ethical Review Board prior to study procedures. Obtained data were analysed using descriptive statistics. Association between the variables were measured using chi-square test.

Results
The mean age of the patients was 43.5 (±14.26) years. Nearly half (44%, n = 274) were middle aged adults, 59.7% were female and 56.0% were involved in agriculture and household chores. Nearly half of the patients (45.7%) were overweight/ obese, 7.9% were smokers and 13.5% had habit of alcohol use. Osteopenia or low bone density was detected in 58.9% patients and 19.4% had osteoporosis. The prevalence of osteoporosis was significantly associated with age group (p = <0.001) and educational status (p = 0.013) of the patients.

Conclusions and recommendations
Osteoporosis and osteopenia are prevalent in patients attending in the hospital. Hence, awareness, early screening, and treatment are necessary for the hospital attended patients to enhance their health and, minimize the risk of osteoporosis and the consequences associated with it.
Asymmetric changes in foot anthropometry with pregnancy may be related to onset of lower limb and low back pain
Authors: Casto Erica M. , Mancinelli Corrie , Meszaros Petronela , McCrory Jean L. 
Published: February 2024

Introduction
Fifty percent of pregnant females experience pain with 20% reporting long-term pain post-partum. Pregnant females undergo changes in foot anthropometry, lower extremity alignment, and joint laxity. It is unknown if asymmetric alterations may be related to development of pain. The purpose of this study was twofold: 1) to compare asymmetric alignment in pregnant females with and without pain during pregnancy and in nulliparous controls and 2) to assess the relationship between asymmetric alignment and pain severity in all participants.

Methods
Ten pregnant females in their third trimester and nine nulliparous controls participated. Bilateral asymmetry of foot length, width, arch index, arch height index, arch rigidity index, arch drop, rearfoot angle, and pelvic obliquity were determined. Joint laxity and musculoskeletal pain were also assessed. ANOVAs were utilized to compare asymmetries between pregnant females reporting pain (n = 5), those not reporting pain (n = 5), and controls. Spearman’s Rho correlations were used to relate asymmetry to pain magnitude (α = 0.05).

Results
No statistical differences (p>0.05) were found between pregnant females with or without pain and controls for any of the metrics. Negative correlations were found between arch index asymmetry and low back pain (p = 0.005), foot length asymmetry and lower leg pain (p = 0.008), and pelvic obliquity and lower leg pain (p = 0.020). Positive correlations were found between foot width asymmetry and knee pain (p = 0.028), as well as arch drop asymmetry and upper leg (p = 0.024), knee (p = 0.005), and lower leg pain (p = 0.019).

Conclusions
This study was successful in identifying potential targets for prevention and treatment of pain in pregnancy. Furthermore, because pain during pregnancy may be predictive of pain post-partum, it is important to conduct future research to determine both if interventions such as footwear or exercise can prevent or treat these asymmetries and prevent post-partum pain.
“Are all referrals necessary?” Experiences and perceptions of maternity healthcare providers on emergency intrapartum referrals in Dar es Salaam, Tanzania
Authors: Selemani Shekha , Mwakyusa Michael O. , Bashiri Selemani , Ezekiel Mangi J. , Mwakawanga Dorkasi L. , Alwy Al-beity Fadhlun M. , Pembe Andrea B. 
Published: February 2024

Background
Intrapartum continuity of care to reduce maternal morbidity and mortality relies heavily on a functional and effective referral system between tiers of care. Capacity building of providers in managing intrapartum referrals is expected to improve the efficiency of the referral system, but this does not always work in practice. This study explored the experiences and perceptions of maternity healthcare providers on emergency intrapartum referrals in Dar es Salaam, Tanzania.

Methods
An exploratory qualitative study was conducted at Amana Regional Referral Hospital and Muhimbili National Hospital in Dar es Salaam. Maternity healthcare providers were purposively recruited based on cadre, working experience of more than three years in the maternity wards. An in-depth interview guide which involved questions and probes was used to conduct eleven interviews. Data was thematically analyzed.

Results
Three major themes emerged, namely: 1) causes of referrals are beyond medical indications; 2) limited maternity healthcare provider capability at referring facilities; and 3) limited communication between referring and receiving facilities. According to maternity healthcare professionals, referrals were seen as a way to minimize blame and a clinical management tool to prevent difficulties. They advocated for more understanding of the skill set among maternity healthcare providers, but some had negative perceptions towards performing their responsibilities.

Conclusions
Skills gaps among maternity healthcare providers at referring hospitals influenced referral decision-making and service provision. There was hostility between referring and receiving hospitals. Capacity-strengthening strategies such as ongoing skills training and changes in attitudes toward referrals require improvements. The referring hospital should only consider referrals as a last resort after other case management has been completed.
‘I do hope more people can benefit from it.’: The qualitative experience of individuals living with osteoarthritis who participated in the GLA:D™ program in Alberta, Canada
Authors: Kania-Richmond Ania , Beaupre Lauren A. , Jessiman-Perreault Geneviève , Tribo Danika , Martyn Jason , Hart David A. , Robert Jill , Slomp Mel , Jones C. Allyson 
Published: February 2024

Introduction
The Good Life with osteoArthritis: Denmark (GLA:DTM) is an evidence-based program designed for individuals with symptomatic hip and knee osteoarthritis (OA). This program has reported improvement in pain, quality of life and self-efficacy, as well as delays in joint replacement surgery for adults with moderate to severe hip or knee OA. Evaluations of GLA:DTM implementation in several countries have focused on effectiveness, training, and feasibility of the program primarily from the provider perspective. Our objective was to examine how the GLA:DTM program was perceived and experienced by individuals with hip and knee OA to inform on-going program refinement and implementation.

Methods
Thirty semi-structured telephone interviews were conducted with participants who completed the GLA:DTM program in Alberta. An interpretive description approach was used to frame the study and thematic analysis was used to code the data and identify emergent themes and sub-themes associated with participants’ experience and perception of the GLA:DTM program.

Results
Most participants had a positive experience of the GLA:DTM program and particularly enjoyed the group format, although some participants felt the group format prevented one-on-one support from providers. Three emergent themes related to acceptability were identified: accessible, adaptable, and supportive. Participants found the program to be accessible in terms of location, cost, and scheduling. They also felt the program was adaptable and allowed for individual attention and translatability into other settings. Finally, most participants found the group format to be motivating and fostered connections between participants.

Conclusion
The GLA:DTM program was perceived as acceptable by most participants, yet the group format may not be useful for all individuals living with OA. Recommended improvements included adapting screening to identify those suited for the group format, providing program access earlier in the disease progression trajectory, modifying educational content based on participants’ knowledge of OA and finally, providing refresher sessions after program completion.
Effect of online intervention based on life skills for mental health, self-efficacy and coping skills among Arab adolescents in the Klang Valley, Malaysia: A cluster randomised controlled trial protocol
Authors: Sherif Yosra , Fattah Azman Ahmad Zaid , Said Salmiah Md , Siddiqah Alimuddin Aishah , Awang Hamidin , Mohammadzadeh Marjan 
Published: February 2024

Background
Migrant children and adolescents face a significantly increased risk of mental health issues. Focusing on this population’s mental health issues is fundamental and requires more attention to detect and reduce these burdens in adulthood. Nevertheless, life skills intervention can improve mental health. Its effects on Arab migrant adolescents have not been tested. Here, an evaluation protocol of the effect of an online life skills-based intervention for improving depression, anxiety, stress, self-efficacy, and coping skills among Arab adolescents in Malaysia will be examined.

Material and methods
This cluster randomised controlled trial (RCT) will involve 207 Arab students (14–18 years old) from 12 Arabic schools in the Klang Valley. The schools will be assigned randomly to an intervention (online life skills programme) or control group at a 1:1 ratio. The researcher will deliver eight one-hour sessions to the intervention group weekly. The control group will receive the intervention at the evaluation end. Both groups will complete assessments at baseline, and immediately and three months after the intervention. The primary outcome is anxiety, depression, and stress [Depression Anxiety and Stress Scale-21 (DASS-21)]. The secondary outcomes are self-efficacy (General Self-Efficacy Scale) and coping skills (Brief COPE Inventory). Data analysis will involve the Generalised Estimation Equation with a 95% confidence interval. P < .05 will indicate significant inter- and intra-group differences.

Discussion
This will be the first cluster RCT of an online life skills education programme involving Arab adolescent migrants in Malaysia. The results could support programme effectiveness for improving the participants’ mental health problems (depression, anxiety, stress), increasing their self-efficacy, and enhancing their coping skills. The evidence could transform approaches for ameliorating migrant children and adolescents’ mental well-being.

Trial registration
The study is registered with the Clinical Trial Registry (Identifier: NCT05370443).
Acinar Cystic Transformation of the Pancreas With Main Pancreatic Duct Dilation and Distal Pancreatic Atrophy
Authors: Ahmed Nehaal , Cao Troy , Chen Wei , Krishna Somashekar G. 
Published: February 2024

ABSTRACT
We report a rare case of a large, slowly progressive acinar cystic transformation (ACT) of the pancreas with main duct dilation and atrophy of the upstream pancreas. The diagnosis was made through endoscopic ultrasound-guided through-the-needle biopsy and histological identification of cuboidal acinar epithelium and characteristic immunohistochemistry findings. Distal pancreatectomy and splenectomy were performed because of elevated carcinoembryonic antigen levels, atypical cells on biopsy, and an increase in cyst size. Owing to the benign nature of this case, postresection surveillance was not necessary.
Inflammatory and neutrophil activation markers in Behcet's disease
Authors: Nurbaeva K. S. , Reshetnyak T. M. , Goloeva R. G. , Lila A. M. , Nasonov E. L. 
Published: February 2024

Behcet's disease (BD) is a systemic vasculitis characterized by recurrent episodes of inflammation with aphthous stomatitis, genital ulcers, skin, joint and internal organ involvement. Currently, there are no reliable laboratory markers that can be used to monitor BD activity. Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) have low sensitivity, so the search for new biomarkers continues. Neutrophil reactivity intensity (NEUT-RI), neutrophil granularity intensity (NEUT-GI), immature granulocytes (IG), neutrophil-to-lymphocyte ratio (NLR), systemic immune inflammation index (SII) are new inflammatory indicators whose role in BD is not well studied.Objective: to evaluate and compare the efficacy of the determination of NEUT-RI, NEUT-GI, IG, SII, NLR, ESR and CRP in the diagnosis of active BD.Material and methods. 84 patients with a reliable diagnosis of BD and 38 healthy controls were included in the study. BD activity was assessed using the Behcet’s Disease Current Activity Form (BDCAF). Patients with BD were divided into two groups according to activity: Group I included 41 patients with high activity (BDCAF >5) and Group II included 43 patients with low activity (BDCAF ≤5). A complete blood count with determination of NEUT-RI, NEUT-GI, IG, SII and NLR was performed in all patients and healthy donors using the Sysmex XN 1000 automated haematology analyzer (Sysmex Сorp, Japan). ESR was determined using the Westergren method. High-sensitivity serum CRP level was determined in all patients with BD (normal range ≤5) by immunonephelometric method.Results and discussion. Patients with active BD had significantly higher levels of neutrophils, SII, NLR, NEUT-RI, IG, ESR and CRP compared to patients with low disease activity. ROC analysis was performed to compare the significance of these inflammatory markers in the assessment of BD activity. The SII had the largest area under the ROC curve (AUC =0.816). The sensitivity and specificity of the SII at a value of 509.75 or higher for determining the active form of BD were 79.4% and 71.8%, respectively.Conclusion. The new inflammatory parameters (SII, NLR, NEUT-RI and IG) and the traditional inflammatory parameters (ESR, CRP, neutrophils) can serve as laboratory markers for BD activity. SII is the most informative parameter to determine BD activity with optimal sensitivity and specificity.