bluuebunny/crossref_metadata_2025_split huggingface dataset:
الصّورة الذهنية لفرنسا لدى الرأي العام الأردني بعد الرّسومات المسيئة للرسول(ص)
Authors: الحمّاد خلف لافي , العليمات فرحان راشد , حمود هديل 
Published: February 2024

تهدف هذه الدّراسة إلى التعرف على الصّورة الذهنية لفرنسا لدى الرأي العام الأردني، خاصة بعد نشر الرّسوم المسيئة للرسول محمّد (ص). وتُعَدّ هذه الدّراسة من الدراسات الوصفية. وفي إطارها تم الاعتماد على المنهج المسحي، واستخدمت أداة الاستبانة الإلكترونية لجمع المعلومات من عيّنة الدّراسة البالغة (370) مفردة من الرأي العام الأردني. وقد توصلت الدّراسة إلى النتائج الآتية:

تبيّن أن صورة فرنسا الذهنية سلبية، خاصة بعد نشر الصّورة المسيئة للرسول (ص)، وأن صورة فرنسا الذهنية الإيجابية لدى الرأي العام الأردني تقلصت بعد حادثة نشر الرّسوم المسيئة.
تبيّن أن الرّسوم المسيئة للرسول (ص) تركت أثراً سلبياً في العلاقات الأردنية الفرنسية في مختلف المجالات، خاصة الاقتصادية.
تبيّن أن هنالك تأثيراً قويّا جداً للحملات الرافضة للرسوم المسيئة للرسول (ص) من وجهة نظر الرأي العام الأردني.
تبيّن أن أفضل الطرق للدفاع عن الرسول (ص) تمثل بمقاطعة منتَجات الدول، وبضائعها التي تسمح بنشر الرّسوم المسيئة للرسول (ص).
تبيّن أن الوسائل الإعلامية العربية هي أكثر الوسائل متابعةً لقضية الرّسوم المسيئة للرسول (ص).
تبيّن أن مواقع التواصل الاجتماعي هي أكثر الوسائل الإعلامية والاتصالية التي تم الاعتماد عليها في التعرف على قضية نشر الرّسوم المسيئة للرسول (ص).
Harnessing Digital Health Solutions to Enhance Medication Adherence in Patients With Depression
Authors: Okoye Victor , Okoye Godwin , Appiah Daniel 
Published: February 2024

ABSTRACT
The growth of digital health solutions is rapidly advancing, and mental health care is rapidly changing due to the enormous explosion of digital technology infrastructure and processes. Digital technology is poised to dramatically alter patient care delivery, thanks to the adoption of artificial intelligence, big data, wearable mobile technology, and network information. This review covers the uptake and implementation of digital solutions for medication adherence in major depressive disorder and explores potential barriers to access.
Factors that Influence the Need to Start Adaptive Radiotherapy
Authors: Roby Nouran Muhammed , Hassan Mohamed , Aboelkasem Mohamed A. , Kamaleldin Maha , Ali Ahmed S. 
Published: February 2024

ABSTRACT

Introduction
Adaptive radiotherapy (ART) is an essential approach to account for anatomical and biological uncertainties. Adaptive radiotherapy is, however, time-consuming, and it is unclear which patients are eligible or when is the best time to start ART.

Methods
This prospective study was conducted at Kasr El-Aini Center of Clinical Oncology and Nuclear Medicine, Cairo, Egypt from January 2019 to December 2020. Thirty patients with pathologically proven, limited-stage small cell or stage I-II non–small cell lung cancer who were either not fit for or refused surgery or had stage III disease were recruited and underwent treatment planning to receive 60 Gy on a conventional 3D conformal radiation schedule with platinum-based chemotherapy. All patients underwent computed tomography (CT) planning within 2 and 4 weeks of starting radiation therapy to assess the need for adaptation. Pulmonary function test and echocardiography findings were assessed at the end of treatment and at 3 and 6 months after treatment, and were compared to the baseline.

Results
We found a significant reduction in mean value of the planning target volume (PTV) in the CT scans at the second (331 cm3) and fourth (257 cm3) weeks of treatment as compared to baseline (342 cm3) (p-value &lt; 0.0001). Adaptation decreased the dose to the organ at risk with statistical significance and with improvement of the target coverage. At week 2 of radiotherapy, the need for adaptation was correlated to the conformity index (p = 0.0473), esophageal V35 (p = 0.0488), esophageal V50 (p = 0.0295), and its mean dose (p = 0.0087). At week 4 it was correlated to forced expiratory volume in 1 second (FEV1) (p = 0.0303), ratio between the forced expiratory volume in 1 second and the forced vital capacity (FEV1/FVC) (p = 0.0024), and echocardiography (p = 0.0183).

Conclusions
Conformity index and esophageal dose constraints can predict the need for adaptation at week 2, whereas baseline pulmonary function parameters and echocardiography can predict the need for adaptation at week 4 of radiotherapy.
O que as revisões sistemáticas dizem sobre o impacto da cirurgia robótica na neurocirurgia?
Authors: Merotto Filipe Faedo , Teixeira Igor Luis Lins , Correia Tarciso Rusivel Rodrigues , Guerra Carine Fontes , Alexandre Kallinka Carneiro , Fernandes Hawand Mousinho seba Salomão , Gonçalves Diana Alves de Oliveira , Sartorio Mallu Mignoni Mazolli , Karoline Petricio Martins  , Feitosa Randyston Brenno , Maurício Matheus Souza de Magalhães , Lessa Adryan Emanuel Cavalcante , Santos Josefa Lívia Matias dos , Camello Caio Calheiros , Silva João Pedro Mello da 
Published: February 2024

Introdução: A neurocirurgia, com suas complexidades intricadas e demandas por precisão extrema, tem sido moldada e transformada ao longo dos anos pela constante evolução da tecnologia médica.
Metodologia: A metodologia adotada para este trabalho compreendeu uma revisão sistemática de literatura, focada em descritores MESH específicos, realizada no banco de dados PUBMED. O período considerado para a busca de artigos abrangeu de 2017 a 2023, visando capturar as mais recentes contribuições à temática. Os descritores MESH selecionados para delinear a pesquisa foram "Robotic Surgical Procedures", "Neurosurgery" e "Minimally Invasive Surgical Procedures".
Resultado: As revisões sistemáticas apresentam um panorama abrangente dos avanços recentes na cirurgia robótica e suas aplicações em diversas áreas. O cenário promissor delineado por essas análises não apenas valida os progressos alcançados, mas também ressalta a necessidade contínua de pesquisa e desenvolvimento para aprimorar ainda mais as práticas cirúrgicas.
Conclusão: A curva de aprendizado, a necessidade de treinamento especializado e as considerações econômicas são aspectos cruciais que moldam a implementação prática da cirurgia robótica no cenário neurocirúrgico.
Implementación de Estrategias Didácticas para la Enseñanza de las Ciencias Naturales (Santivañez, 2017) en el Grado 5° de la Institución Educativa Mercedes Romero de Quintero- El Totumo, La Guajira – Colombia
Authors: Bermudez Argote Fabrina Keyta 
Published: February 2024

En el contexto educativo las estrategias didácticas son un conjunto de técnicas, actividades y recursos, que desarrollan las habilidades de aprendizaje de los estudiantes. El objetivo de esta investigación es analizar la incidencia de la implementación de estrategias didácticas, propuestas por Santivañez (2017), en las prácticas de enseñanza de las Ciencias Naturales en el grado 5° de la IE Mercedes Romero de Quintero corregimiento del Totumo, municipio de San Juan del Cesar la Guajira – Colombia. Con el fin de establecer un aprendizaje relevante en los estudiantes, favoreciendo sus procesos y convirtiéndose en un instrumento pedagógico de apoyo en las prácticas educativas, en el marco de la enseñanza para el desarrollo de competencias prácticas, actitudinales, y cognitivas que les permita poner en evidencia su capacidad de dar respuesta positiva a los procesos. Metodológicamente se orientó bajo el enfoque cualitativo con un diseño de investigación que corresponde a la Investigación Acción Participativa, empleando como técnicas de recolección de la información la entrevista, encuestas, la rúbrica de observación directa y diarios de campo. Para la muestra representativa, se tomaron 15 participantes, los cuales dan respuesta a categorías como: aspectos metodológicos didácticos y pedagógicos, espíritu científico, y la percepción de los estudiantes frente a la propuesta pedagógica. Se espera que el estudio contribuya a implementar estrategias didácticas para la enseñanza de las ciencias naturales en los estudiantes de grado quinto, evaluando la efectividad de la teoría mencionada en mejora de un aprendizaje significativo.
Correlation of plasma D-dimers with stages of liver cirrhosis and its complications
Authors: Volkanovska Anche , Dejanova Violeta , Andreevski Vladimir , Trajkovska Meri , Labudovikj Danica 
Published: February 2024

Aim of the study: To investigate plasma D-dimer levels in correlation with Child-Pugh-Turcotte (CTP) and Model for End-Stage Liver Disease (MELD) scores in patients with liver cirrhosis (LC) of different severity, as well as the correlation with LC-associated clinical, biochemical parameters and complications. Material and methods: Fifty patients with LC were divided in three groups according to LC severity using the CTP Score (CTP-A, CTP-B, CTP-C). The levels of D-dimer were measured in sodium-citrate plasma on Siemens, BCS XP Blood Coagulometer. Kruskal-Wallis test was used to compare D-dimer levels between the groups. Mann-Whitney U test was used to evaluate the difference of D-dimer levels in groups with different MELD score, and to evaluate the difference in D-dimer levels in patients with presence or absence of ascites and the difference of D-dimer levels in patients with or without spontaneous bacterial peritonitis (SBP). Pearson’s coefficient of correlation was used to evaluate the correlation between D-dimer levels with MELD score and the correlation between D-dimer levels and the concentration of LC-associated biochemical, clinical parameters and complications. Results: D-dimer levels increased with severity of the disease as assessed with CTP and MELD scores, with a statistically significant difference between the groups (p=.0000 and p=.0001, respectively). Group CTP-C demonstrated the highest D-dimer levels, followed by groups B and A. Patients with SBP had significantly higher levels of D-dimers than patients without SBP (p=.0006). A significant positive correlation between D-dimers and CTP and MELD score was detected (r= 0.74 and r=0.44, respectively; p<.001). A correlation between D-dimer levels and several biochemical parameters characterizing progressive liver dysfunction was observed. From all investigated biochemical parameters, the highest significant correlation was detected between D-dimer levels and the concentration of serum albumin (r= -0.65, p<.001). Conclusions: Plasma D-dimer levels are tightly correlated with the degree of liver dysfunction and LC-associated complications. Therefore, D-dimer levels could be utilized as a prognostic stratification marker and adjunctive diagnostic marker in LC-associated complications.
Effect of vaccination and number of doses on disease severity and mortality in Covid -19 positive hospitalized patients
Authors: Dimitrov Ivica , Sazdov Darko 
Published: February 2024

The COVID-19 pandemic, caused by the novel SARS-CoV-2 virus, started in December 2019 in the city Wuhan, province Hubei in the Republic of China. The disease quickly became pandemic and infected 48.539.872 people and had a mortality of 1.232.791 in 215 countries all over the world resulting in economic and healthcare collapse. On 11-th of March the World Health Organisation declared COVID 19 as pandemic. SARS-CoV-2 (severe form of acute respiratory syndrome coronavirus 2) as the cause of COVID 19 is the member of the coronavirus family along with MERS-CoV and SARS-CoV-1which cause severe respiratory infections that are highly contagious and have very high mortality. The pandemic character, the high morbidity and mortality and rehabilitation resulted in a massive vaccine production as an attempt to control the spread of the SARS CoV-2 virus and reduce the morbidity and mortality, especially in the most vulnerable population groups. The aim of the study was to evaluate the association between vaccination status, number of doses and disease severity, length of hospital stay and mortality. Material and Methods: In this case-control study we included 230 male and female patients admitted in the Covid Centre in Acibadem Clinical Hospital in Skopje from March 2021 to February 2022. Patients were divided in two groups according to their vaccination status. Data about patients demographics, comorbidities, vaccination, number of doses received, type of oxygen and ventilation support, length of stay and patient outcome were collected. Results: A total of 230 COVID-19 positive hospitalized patients participated in the study. 50.4% of them were vaccinated, of which 86.2% received two doses, 11.2% received one and 2.6% received three doses of vaccines. A significant association was registered between lethal outcome and vaccination (PearsonChi-square: 5.32523, p=.0210), association with number of doses of vaccination (PearsonChi-square: 7.66262, p=.043524), association with type of ventilation - NIV, HFO, IMV (PearsonChi-square: 177.399, df=3, p=0.000), associationwithcomorbidity (3.90770, p=.0480). Conclusion: Vaccination against Covid-19 and number of doses have a significant impact on disease severity, progression and outcome of the disease.
Effectiveness of an online parenting program for childhood anxiety in North Macedonia
Authors: Kunovski Ivo , Raleva Marija 
Published: February 2024

Anxiety is considered a basic and adaptive emotion. However, anxiety problems are one of the most prevalent mental health problems, with multiple negative effects and a tendency to worsen with age. The high prevalence rates and their negative consequences accent the importance of developing timely and effective prevention strategies. The aim of the study was to evaluate the effectiveness of an online parenting program in reducing anxiety symptoms in young children in the Republic of North Macedonia. Materials and methods: A controlled randomized controlled study was conducted including parents of children aged 2-9 years old in North Macedonia. Eligible parents were assessed at baseline and post-intervention, using self-report questionnaires on sociodemographic characteristics and childhood anxiety (CBCL anxiety scale, CBCL-A; CBCL anxiety/depression scale, CBCL-AD). Parents were assigned to five group sessions of a parenting program, as the intervention group, or a structured group presentation, as a control group. Results: A total of 288 parents were included in the study. The findings showed significant reductions in childhood anxiety symptoms reported by parents in both the parenting program and the active control condition. However, between-group comparisons showed no significant differences between the two conditions. Conclusions:The study is the first to evaluate the effectiveness of an online group parenting program in reducing anxiety symptoms in young children in North Macedonia. The findings demonstrate that it is possible to achieve a significant change in child anxiety problems, using technology-assisted methods of intervention delivery in the country.
Energetic solutions to rate-independent large-strain elasto-plastic evolutions driven by discrete dislocation flow
Authors: Rindler Filip 
Published: February 2024

This work rigorously implements a recent model of large-strain elasto-plastic evolution in single crystals where the plastic flow is driven by the movement of discrete dislocation lines. The model is geometrically and elastically nonlinear, that is, the total deformation gradient splits multiplicatively into elastic and plastic parts, and the elastic energy density is polyconvex. There are two internal variables: The system of all dislocations is modeled via one-dimensional boundaryless integral currents, whereas the history of plastic flow is encoded in a plastic distortion matrix-field. As our main result, we construct an energetic solution in the case of a rate-independent flow rule. Besides the classical stability and energy balance conditions, our notion of solution also accounts for the movement of dislocations and the resulting plastic flow. Because of the path-dependence of plastic flow, a central role is played by so-called “slip trajectories”, that is, the surfaces traced out by moving dislocations, which we represent as integral 2-currents in space-time. The proof of our main existence result further crucially rests on careful a priori estimates via a nonlinear Gronwall-type lemma and a rescaling of time. In particular, we have to account for the fact that the plastic flow may cause the coercivity of the elastic energy functional to decay along the evolution, and hence the solution may blow up in finite time.
Phospholipase A2 enzymes PLA2G2A and PLA2G12B as potential diagnostic and prognostic biomarkers in cholangiocarcinoma
Authors: Qiu Chen , Xiang Yu-Kai , Da Xuan-Bo , Zhang Hong-Lei , Kong Xiang-Yu , Hou Nian-Zong , Zhang Cheng , Tian Fu-Zhou , Yang Yu-Long 
Published: February 2024

BACKGROUND
Phospholipase A2 (PLA2) enzymes are pivotal in various biological processes, such as lipid mediator production, membrane remodeling, bioenergetics, and maintaining the body surface barrier. Notably, these enzymes play a significant role in the development of diverse tumors.
AIM
To systematically and comprehensively explore the expression of the PLA2 family genes and their potential implications in cholangiocarcinoma (CCA).
METHODS
We conducted an analysis of five CCA datasets from The Cancer Genome Atlas and the Gene Expression Omnibus. The study identified differentially expressed genes between tumor tissues and adjacent normal tissues, with a focus on PLA2G2A and PLA2G12B. Gene Set Enrichment Analysis was utilized to pinpoint associated pathways. Moreover, relevant hub genes and microRNAs for PLA2G2A and PLA2G12B were predicted, and their correlation with the prognosis of CCA was evaluated.
RESULTS
PLA2G2A and PLA2G12B were discerned as differentially expressed in CCA, manifesting significant variations in expression levels in urine and serum between CCA patients and healthy individuals. Elevated expression of PLA2G2A was correlated with poorer overall survival in CCA patients. Additionally, the study delineated pathways and miRNAs associated with these genes.
CONCLUSION
Our findings suggest that PLA2G2A and PLA2G12B may serve as novel potential diagnostic and prognostic markers for CCA. The increased levels of these genes in biological fluids could be employed as non-invasive markers for CCA, and their expression levels are indicative of prognosis, underscoring their potential utility in clinical settings.
Influence of donor age on liver transplantation outcomes: A multivariate analysis and comparative study
Authors: Bezjak Miran , Stresec Ivan , Kocman Branislav , Jadrijević Stipislav , Filipec Kanizaj Tajana , Antonijević Miro , Dalbelo Bašić Bojana , Mikulić Danko 
Published: February 2024

BACKGROUND
The growing disparity between the rising demand for liver transplantation (LT) and the limited availability of donor organs has prompted a greater reliance on older liver grafts. Traditionally, utilizing livers from elderly donors has been associated with outcomes inferior to those achieved with grafts from younger donors. By accounting for additional risk factors, we hypothesize that the utilization of older liver grafts has a relatively minor impact on both patient survival and graft viability.
AIM
To evaluate the impact of donor age on LT outcomes using multivariate analysis and comparing young and elderly donor groups.
METHODS
In the period from April 2013 to December 2018, 656 adult liver transplants were performed at the University Hospital Merkur. Several multivariate Cox proportional hazards models were developed to independently assess the significance of donor age. Donor age was treated as a continuous variable. The approach involved univariate and multivariate analysis, including variable selection and assessment of interactions and transformations. Additionally, to exemplify the similarity of using young and old donor liver grafts, the group of 87 recipients of elderly donor liver grafts (≥ 75 years) was compared to a group of 124 recipients of young liver grafts (≤ 45 years) from the dataset. Survival rates of the two groups were estimated using the Kaplan-Meier method and the log-rank test was used to test the differences between groups.
RESULTS
Using multivariate Cox analysis, we found no statistical significance in the role of donor age within the constructed models. Even when retained during the entire model development, the donor age's impact on survival remained insignificant and transformations and interactions yielded no substantial effects on survival. Consistent insignificance and low coefficient values suggest that donor age does not impact patient survival in our dataset. Notably, there was no statistical evidence that the five developed models did not adhere to the proportional hazards assumption. When comparing donor age groups, transplantation using elderly grafts showed similar early graft function, similar graft (P = 0.92), and patient survival rates (P = 0.86), and no significant difference in the incidence of postoperative complications.
CONCLUSION
Our center's experience indicates that donor age does not play a significant role in patient survival, with elderly livers performing comparably to younger grafts when accounting for other risk factors.
Laparoscopic left hemihepatectomy guided by indocyanine green fluorescence: A cranial-dorsal approach
Authors: Wang Xing-Ru , Li Xiao-Ju , Wan Dan-Dan , Zhang Qian , Liu Tian-Xi , Shen Zong-Wen , Tong Hong-Xing , Li Yan , Li Jian-Wei 
Published: February 2024

BACKGROUND
Advancements in laparoscopic technology and a deeper understanding of intrahepatic anatomy have led to the establishment of more precise laparoscopic hepatectomy (LH) techniques. The indocyanine green (ICG) fluorescence navigation technique has emerged as the most effective method for identifying hepatic regions, potentially overcoming the limitations of LH. While laparoscopic left hemihepatectomy (LLH) is a standardized procedure, there is a need for innovative strategies to enhance its outcomes.
AIM
To investigate a standardized cranial-dorsal strategy for LLH, focusing on important anatomical markers, surgical skills, and ICG staining methods.
METHODS
Thirty-seven patients who underwent ICG fluorescence-guided LLH at Qujing Second People's Hospital between January 2019 and February 2022 were retrospectively analyzed. The cranial-dorsal approach was performed which involves dissecting the left hepatic vein cephalad, isolating the Arantius ligament , exposing the middle hepatic vein, and dissecting the parenchyma from the dorsal to the foot in order to complete the anatomical LLH. The surgical methods, as well as intra- and post-surgical data, were recorded and analyzed. Our hospital’s Medical Ethics Committee approved this study (Ethical review: 2022-019-01).
RESULTS
Intraoperative blood loss during LLH was 335.68 ± 99.869 mL and the rates of transfusion and conversion to laparotomy were 13.5% and 0%, respectively. The overall incidence of complications throughout the follow-up (median of 18 months; range 1-36 months) was 21.6%. No mortality or severe complications (level IV) were reported.
CONCLUSION
LLH has the potential to become a novel, standardized approach that can effectively, safely, and simply expose the middle hepatic vein and meet the requirements of precision surgery.