bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prophylactic and Therapeutic Efficacy of Ultrasonicated Rosmarinus officinalis Ethanolic Extract and its Chitosan-Loaded Nanoparticles Against Eimeria tenella Infected Broiler Chickens
Authors: Kasem Shaimaa M. , Mira Nabila M. , Helal Ibrahim B. , Mahfouz Magdy E. 
Published: March 2024

Abstract
Purpose
The in vivo efficacy of ultrasonicated Rosmarinus officinalis ethanolic extract (UROEE) and its chitosan-loaded nanoparticles (UROEE-CsNPs) was investigated as a dietary prophylactic agent and as a therapeutic treatment against Eimeria tenella infected broiler chickens.

Methods
Chickens were infected with 4 × 104E. tenella oocysts at 21 days old for primary infection and with 8 × 104 oocysts at 35 days old for secondary infection. Eleven experimental groups were conducted. Dietary addition of 100 mg/kg UROEE and 20 mg/kg for CsNPs as well as UROEE-CsNPs were included for prophylactic groups from day 1 to 42. The same doses were used for therapeutic treatment groups for 5 constitutive days. Oocyst output in feces was counted. Histopathological and immunohistochemical studies were conducted. Gene expression of pro-inflammatory cytokines as IFN-γ, IL-1β and IL-6 as well as anti-inflammatory cytokines as IL-10 and TGF-β4 was analyzed using semi-quantitative reverse transcriptase-PCR.

Results
The results showed an efficacy of UROEE, CsNPs and UROEE-CsNPs in reduction of oocyst excretion and improving the cecal tissue architecture. CD4+ and CD8+ T lymphocytes protein expression were reduced. E. tenella infection lead to upregulation of pro-inflammatory cytokines as IFN-γ, IL-1β, IL-6 and anti-inflammatory cytokines as TGF-β4 following primary infection, while their expression was downregulated following secondary infection.

Conclusion
The dietary prophylactic additives and therapeutic treatments with UROEE, CsNPs and UROEE-CsNPs could decrease the inflammatory response to E. tenella as indicated by oocyst output reduction, histopathological improvements, CD4+ and CD8+ T cells protein expression reduction as well as reducing mRNA expression levels of the tested cytokines following primary and secondary infections. Consequently, these results will help to develop better-combating strategies for the control and prevention of coccidiosis on poultry farms as a dietary prophylactic agent or as a therapeutic treatment.

Graphical Abstract
Eating disorders and COVID-19 - different or just more?
Authors: Rafferty Cathal , O’Donnell Angela , Campbell Sally , Sun Bohan , King Jenny , Ali Zeinab , Lynch Diarmuid , Barrett Elizabeth , Richardson Sarah , Clifford Michelle , McNicholas Fiona 
Published: March 2024

Abstract
Background
COVID-19 saw an increase in child mental health presentations internationally. Clinicians analogised the exponential increase in anorexia nervosa to a ‘tsunami’ or ‘outbreak’, raising parallel concerns regarding medical and psychological risks (Marsh in The Guardian, 2021; Leask in NZ Herald, 2021; Monteleone et al. in Eat Weight Disord 26(8):2443–2452, 2021) . It is unclear whether Ireland emulated this picture of increased referrals with increased medical compromise.

Aims
This paper examines both rates and clinical profiles of child eating disorder presentations in the Republic of Ireland (ROI), across different clinical settings.

Methods
Following ethical approval, retrospective chart reviews were conducted in a community eating disorder service and in two paediatric hospital settings. The time frame of the different studies ranged from January 2016 to December 2022.

Results
Community eating disorder services saw significantly higher referral rates post COVID-19 (3.78/month vs. 2.31/month, p = 0.02), with a shorter duration of illness (4.8 months vs. 7.4 months, p = 0.001), but no significant difference in ideal body weight % (IBW%) at referral (85.32% vs. 83.7%, p = 0.1). Both paediatric hospitals witnessed significantly increased referrals post-COVID-19 (hospital 1; 4.38/month vs. 1.93/month, p = 0.0001; hospital 2; 2.8/month vs. 0.92/month, p < 0.0001), but no significant difference in IBW% at assessment (hospital 1; 82.7% vs. 81.39%, p = 0.673; hospital 2; 81.5% vs. 83%, p = 0.563). There was no significant difference in clinical profile, management, or duration of hospital stay.

Conclusions
This study supports the growing consensus of a pandemic specific increase in eating disorder referrals to both medical and psychiatry services. However, there was little to indicate a change in clinical profile or severity. Ongoing monitoring of referrals is necessary to ensure adequate service availability and expertise.
JAK-STAT Signaling and Beyond in the Pathogenesis of Spondyloarthritis and Their Clinical Significance
Authors: Raychaudhuri Siba P. , Shah Ruchi J. , Banerjee Sneha , Raychaudhuri Smriti K. 
Published: March 2024

Abstract
Purpose of Review
Janus kinase–signal transducers and activators of transcription cell signaling proteins (JAK-STATs) play a key regulatory role in functioning of several inflammatory cytokines. JAK-STAT signaling proteins are the key regulators of the cytokine/cytokine receptor system involved in the pathogenesis of various autoimmune disease including spondyloarthritis (SpA). This article mainly highlights the JAK-STAT signaling system, its association with the relevant cytokine/cytokine-receptor system, and its regulatory role in pathogenesis of SpA. Also, we have briefly addressed the principle for the use JAKi in SpA and the current status of use of JAK inhibitors (JAKi) in SpA.

Recent Findings
Recent developments with newer JAK molecules as well as other molecules beyond JAK inhibitors are now an exciting field for the development of novel therapies for autoimmune diseases and various malignant conditions. In this article, we have provided a special emphasis on how various cell signaling systems beyond JAK/STAT pathway are relevant to SpA and have provided a comprehensive review on this upcoming field in respect to the novel TYK2 inhibitors, RORγT inhibitors, mTOR inhibitors, NGF inhibitors, and various STAT kinase inhibitors.

Summary
SpA are a group of autoimmune diseases with multifactorial etiologies. SpA is linked with genetic predisposition, environmental risk factors, and the immune system-mediated systemic inflammation. Here, we have provided the regulatory role of JAK/STAT pathway and other intracellular signaling system in the pathogenesis of SpA and its therapeutic relevance.
The Sources of Happiness in Preadolescence and Adolescence: A Multi-Method and Multi-Informant Perspective
Authors: Izzo Flavia , Saija Edoardo , Pallini Susanna , Ioverno Salvatore , Baiocco Roberto , Pistella Jessica 
Published: March 2024

AbstractResearch on happiness in preadolescence and adolescence has been limited regarding the sources of happiness. The present study aims to explore such sources in preadolescents and adolescents through a multi-method and multi-informant approach. Semi-structured interviews were conducted with 77 family triads: children (age range: 11–19; M = 13.90, SD = 2.70; 61% female), mothers (M = 47.50, SD = 4.35), and fathers (M = 50.53, SD = 5.30). The triads were asked to define happiness from children’s perspective, describe what makes children happy, and indicate children’s levels of happiness. Using quantitative data, preadolescents exhibited higher individual happiness levels than adolescents, and fathers reported higher levels of children’s happiness than mothers. Through Thematic Analysis, five primary sources of happiness emerged: Social relationships, Family relationships, Personal interests, Achievement, and Entertainment. Social relationships was the most recurring theme across the narratives of both preadolescents/adolescents and parents. The second most recurring theme was Personal interests for preadolescents/adolescents and Family relationships for parents. Parents notably more frequently mentioned Achievement than children. Males displayed a higher propensity to report the Entertainment theme than females, while females reported the Family relationships and Social relationships themes more frequently. Preadolescents exhibited a higher occurrence of the Entertainment and Family relationships themes than adolescents. Regarding the concordance of themes between children and their parents, low overall levels of agreement were observed, all below 40%. The highest levels of concordance were found between mothers and fathers rather than between parents and children. The results could provide valuable insights to parents and educators on how to help youth promote their happiness.
Annular impinging jets controlled by synthetic jets inducing a swirling flow character
Authors: Devani Y. , Antošová Z. , Trávníček Z. 
Published: March 2024

AbstractExperimental research was conducted on an annular air jet. The active flow control was introduced by means of tangentially arranged synthetic jets. Flow visualization and measurements of the flow velocity and stagnation pressure on an impingement wall were performed. Tests were carried out with Reynolds numbers ranging from 4000 to 10,000 (evaluated from the outer exit diameter of the annular nozzle). Bistability and hysteretic effects were revealed, because two alternative flow field patterns (A and B) were identified under the same boundary conditions. In the A pattern, a small recirculation area (bubble) of separated flow was attached to the nozzle centerbody. In the B pattern, a large recirculation area of separated flow bridged the entire nozzle-to-wall distance. The effect of the Reynolds number was evaluated: the hysteresis and bistability were not observed for Re ≥ 9000. Concerning the effect of flow control, it was concluded that a moderate swirling effect can effectively suppress the hysteresis and bistability.
Graphical abstract
Detection of upper limb abrupt gestures for human–machine interaction using deep learning techniques
Authors: Digo Elisa , Polito Michele , Pastorelli Stefano , Gastaldi Laura 
Published: March 2024

AbstractIn the manufacturing industry the productivity is contingent on the workers’ well-being, with operators at the center of the production process. Moreover, when human–machine interaction occurs, operators’ safety is a key requirement. Generally, typical human gestures in manipulation tasks have repetitive kinetics, however external disturbances or environmental factors might provoke abrupt gestures, leading to improper interaction with the machine. The identification and characterization of these abrupt events has not yet been thoroughly studied. Accordingly, the aim of the current research was to define a methodology to ready identify human abrupt movements in a workplace, where manipulation activities are carried out. Five subjects performed three times a set of 30 standard pick-and-place tasks paced at 20 bpm, wearing magneto-inertial measurement units (MIMUs) on their wrists. Random visual and acoustic alarms triggered abrupt movements during standard gestures. The recorded signals were processed by segmenting each pick-and-place cycle. The distinction between standard and abrupt gestures was performed through a recurrent neural network applied to acceleration signals. Four different pre-classification methodologies were implemented to train the neural network and the resulting confusion matrices were compared. The outcomes showed that appropriate preprocessing of the data allows more effective training of the network and shorter classification time, enabling to achieve accuracy greater than 99% and F1-score better than 90%.
Elastic Stable Intramedullary Nailing Versus Plate Internal Fixation for Pediatric Diaphyseal Femur Fractures: A Systematic Review and Meta-analysis
Authors: Liu Wanlin , Li Wenqiang , Bai Rui , Xu Xiangyu , Zhao Zhenqun , Wang Yan 
Published: March 2024

Abstract
Background
Elastic stable intramedullary nailing (ESIN) and plates are currently the main internal fixation for treating Pediatric Diaphyseal Femur Fractures (PDFF), and the optimal choice of internal fixation is controversial. The purpose of this meta-analysis is to compare the surgical outcomes and complications of the two fixation methods.

Materials and Methods
MEDLINE, Embase, and the Cochrane Library were systematically searched for studies published up to March, 2023, that compared ESIN and plate fixation techniques for treating PDFF. Pooled analysis identified differences in surgical outcomes between ESIN and plate, mainly regarding surgical outcomes and postoperative complications, such as time at surgery, fracture healing time, blood loss and related complications.

Results
We included 10 studies with 775 patients with PDFF in our review. Of these, 428 and 347 were treated with ESIN and Plate, respectively. In terms of postoperative complications, ESIN led to a shorter surgery time [MD = − 28.93, 95% CI (− 52.88 to − 4.98), P < 0.05], less blood loss [MD = − 66.94, 95% CI (− 87.79 to − 46.10), P < 0.001] and more fracture healing time [MD = 2.65, 95% CI (1.22–4.07), P < 0.001]. In terms of postoperative complications, ESIN led to fewer fections (RR = 0.77, 95% CI 0.37, 1.60, P = 0.48), fewer angulation deformities (RR = 0.80, 95% CI 0.35, 1.83, P = 0.60) and more prominent implants (RR = 3.36, 95% CI 1.88, 6.01, P < 0.001), more delayed unions (RR = 4.06, 95% CI 0.71, 23.06, P = 0.11).

Conclusions
ESIN and Plate have similar rates of complications besides a prominent implant rate, while ESIN has a shorter period of operation and less intraoperative bleeding. Although both options are suitable, the results of this study support the use of ESIN rather than plates in the treatment of PDFF in terms of complication rates. In clinical applications, surgeons should choose the appropriate treatment method according to the actual situation.
Satellite NO2 Trends and Hotspots Over Offshore Oil and Gas Operations in the Gulf of Mexico
Authors: Fedkin Niko M. , Stauffer Ryan M. , Thompson Anne M. , Kollonige Debra E. , Wecht Holli D. , Elguindi Nellie 
Published: March 2024

AbstractThe Outer Continental Shelf of the Gulf of Mexico (GOM) is populated with numerous oil and natural gas (ONG) platforms which produce NOx (NOx = NO + NO2), a major component of air pollution. The Bureau of Ocean Energy Management (BOEM) is mandated to ensure that the air quality of coastal states is not degraded by these emissions. As part of a NASA‐BOEM collaboration, we conducted a satellite data‐based analysis of nitrogen dioxide (NO2) patterns and trends in the GOM. Data from the OMI and TROPOMI sensors were used to obtain 18+ year records of tropospheric column (TrC) NO2 in three GOM regions: (a) Houston urban area, (b) near shore area off the Louisiana coast, and a (c) deepwater area off the Louisiana coast. The 2004–2022 time series show a decreasing trend for the urban (−0.027 DU/decade) and near shore (−0.0022 DU/decade) areas, and an increasing trend (0.0019 DU/decade) for the deepwater area. MERRA‐2 wind and TROPOMI NO2 data were used to reveal several NO2 hotspots (up to 25% above background values) under calm wind conditions near individual platforms. The NO2 signals from these deepwater platforms and the high density of shallow water platforms closer to shore were confirmed by TrC NO2 anomalies of up to 10%, taking into account the monthly TrC NO2 climatology over the GOM. The results presented in this study establish a baseline for future estimates of emissions from the ONG hotspots and provide a methodology for analyzing NO2 measurements from the new geostationary TEMPO instrument.
Impact of Direct Radar Reflectivity Data Assimilation on the Simulation of Mesoscale Descending Inflow and Secondary Eyewall Formation in Hurricane Matthew (2016)
Authors: Li Tsung‐Han , Wang Xuguang , Lu Xu 
Published: March 2024

AbstractThe impact of assimilating ground‐based radar reflectivity on the rainband structure and secondary eyewall formation (SEF) of Hurricane Matthew (2016) is investigated within the framework of the Hurricane Weather Research and Forecasting model and its hybrid three‐dimensional ensemble‐variational data assimilation (DA) system. Compared to the control experiment (no radar reflectivity DA), the radar reflectivity DA experiment shows a clear signal of concentric eyewall and eyewall replacement cycle. Results demonstrate that radar reflectivity DA improves the stratiform rainband analysis, resulting in the mid‐level cooling associated with mesoscale descending inflow (MDI). The MDI further contributes to the low‐level acceleration maximum with boundary layer dynamics and triggers new convective updrafts in the SEF region. Momentum budget analysis also suggests that the mean vertical advection of absolute angular momentum plays an important role in the local momentum tendency in the SEF region in Hurricane Matthew (2016).
Regime Shifts in Lake Oxygen and Temperature in the Rapidly Warming High Arctic
Authors: Klanten Yohanna , MacIntyre Sally , Fitzpatrick Cameron , Vincent Warwick F. , Antoniades Dermot 
Published: March 2024

AbstractGlobal warming is destabilizing the cryosphere, with consequences for glaciers, permafrost, sea ice and lake ice. Polar lakes have short ice‐free seasons, and small changes in ice cover duration have the potential to provoke alterations to ecosystem structure. However, these lakes are understudied, and the consequences for mixing regimes, thermal structures and biogeochemical processes remain unclear. We measured three annual cycles of dissolved oxygen, temperature and specific conductivity in a lake at ∼83°N to investigate limnological processes and their interannual variability. There were sharp interannual contrasts in lake dynamics, with state shifts in mixing, stratification and oxygen regimes due to air temperature variability and meteorological events. We also observed unusual thermal profiles that were associated with solute gradients. These striking differences underscore the sensitivity of high Arctic lakes to interannual variations in meteorological forcing, and their susceptibility to regime shifts in response to ongoing global change.
Sediment Freeze‐On and Transport Near the Onset of a Fast‐Flowing Glacier in East Antarctica
Authors: Franke Steven , Wolovick Michael , Drews Reinhard , Jansen Daniela , Matsuoka Kenichi , Bons Paul D. 
Published: March 2024

AbstractUnderstanding the material properties and physical conditions of basal ice is crucial for a comprehensive understanding of Antarctic ice‐sheet dynamics. Yet, direct data are sparse and difficult to acquire. Here, we employ ultra‐wideband radar to map high‐backscatter zones near the glacier bed within East Antarctica's Jutulstraumen drainage basin. Our backscatter analysis reveals that the basal ice in an area of ∼10,000 km2 is composed of along‐flow oriented sediment‐laden basal ice units connected to the basal substrate, extending up to several hundred meters thick. Three‐dimensional thermomechanical modeling supports that these units form via basal freeze‐on of subglacial water that originated from further upstream. Our findings suggest that basal freeze‐on, and the entrainment and transport of subglacial material play a significant role in an accurate representation of material, physical, and rheological properties of the Antarctic ice sheet's basal ice, ultimately enhancing the accuracy and reliability of ice‐sheet modeling.
The Impact of Serial Cyclone Clustering on Extremely High Sea Levels in the Baltic Sea
Authors: Rantanen Mika , van den Broek Daan , Cornér Joona , Sinclair Victoria A. , Johansson Milla M. , Särkkä Jani , Laurila Terhi K. , Jylhä Kirsti 
Published: March 2024

AbstractIn the Baltic Sea, sea level variations are often very pronounced. During the winter season, storm surges caused by strong extratropical cyclones (ETCs) can have major societal impacts on coastal cities. In this study, using reanalysis‐based cyclone tracks and in‐situ tide gauge records, we show that serial cyclone clustering (SCC) leads to higher sea levels in the Baltic Sea than situations where only one ETC passes the tide gauge. Consequently, almost half of extreme sea level events in the Baltic Sea are associated with cyclone clustering periods. For example, in Helsinki, 45% of the extreme sea level events coincided with SCC periods of three or more ETCs, while only 6% of the events coincided with a single ETC. Our study represents a significant advance in the understanding of the factors influencing sea level variations in the Baltic Sea.
Slow Slip Events in New Zealand: Irregular, yet Predictable?
Authors: Truttmann S. , Poulet T. , Wallace L. , Herwegh M. , Veveakis M. 
Published: March 2024

AbstractCurrent earthquake forecasting approaches are mainly based on probabilistic assumptions, as earthquakes seem to occur randomly. Such apparent randomness can however be caused by deterministic chaos, rendering deterministic short‐term forecasts possible. Due to the short historical and instrumental record of earthquakes, chaos detection has proven challenging, but more frequently occurring slow slip events (SSE) are promising candidates to probe for determinism. Here, we characterize the SSE signatures obtained from GNSS position time series in the Hikurangi Subduction Zone (New Zealand) to investigate whether the seemingly random SSE occurrence is governed by chaotic determinism. We find evidence for deterministic chaos for stations recording shallow SSEs, suggesting that short‐term deterministic forecasting of SSEs, similar to weather forecasts, might indeed be possible over timescales of a few weeks. We anticipate that our findings could open the door for next‐generation SSE forecasting, adding new tools to existing probabilistic approaches.
Along‐Strike Variations of Alaska Subduction Zone Structure and Hydration Determined From Amphibious Seismic Data
Authors: Li Zongshan , Wiens Douglas A. , Shen Weisen , Shillington Donna J. 
Published: March 2024

AbstractWe develop a 3‐D isotropic shear velocity model for the Alaska subduction zone using data from seafloor and land‐based seismographs to investigate along‐strike variations in structure. By applying ambient noise and teleseismic Helmholtz tomography, we derive Rayleigh wave group and phase velocity dispersion maps, then invert them for shear velocity structure using a Bayesian Monte Carlo algorithm. For land‐based stations, we perform a joint inversion of receiver functions and dispersion curves. The forearc crust is relatively thick (35–42 km) and has reduced lower crustal velocities beneath the Kodiak and Semidi segments, which may promote higher seismic coupling. Bristol Bay Basin crust is relatively thin and has a high‐velocity lower layer, suggesting a dense mafic lower crust emplaced by the rifting processes. The incoming plate shows low uppermost mantle velocities, indicating serpentinization. This hydration is more pronounced in the Shumagin segment, with greater velocity reduction extending to 18 ± 3 km depth, compared to the Semidi segment, showing smaller reductions extending to 14 ± 3 km depth. Our estimates of percent serpentinization from VS reduction and VP/VS are larger than those determined using VP reduction in prior studies, likely due to water in cracks affecting VS more than VP. Revised estimates of serpentinization show that more water subducts than previous studies, and that twice as much mantle water is subducted in the Shumagin segment compared to the Semidi segment. Together with estimates from other subduction zones, the results indicate a wide variation in subducted mantle water between different subduction segments.