bluuebunny/crossref_metadata_2025_split huggingface dataset:
Calcinosis cutis presenting years before other clinical manifestations of juvenile dermatomyositis: Report of two cases
Authors: Wananukul Siriwan , Pongprasit Prapai , Wattanakrai Penpun 
Published: June 2007

SUMMARYCalcinosis cutis in dermatomyositis is dystrophic calcification appearing late in the course of the disease. Two cases are reported here of calcinosis cutis that presented years before other clinical manifestations of juvenile dermatomyositis. The first case was a 14‐year‐old Thai girl who had asymptomatic subcutaneous nodules that spontaneously ruptured, exuding a chalky discharge and healing with an atrophic scar 8 years before the onset of other clinical manifestations of juvenile dermatomyositis; that is, Gottron's papules, proximal muscle weakness grade IV/V with atrophy, slightly elevated serum creatinine phosphokinase level and an abnormal electromyogram compatible with myopathy. The second case was a 15‐year‐old Thai boy who had calcinosis cutis 3 years before the onset of other clinical manifestations of juvenile dermatomyositis, and the calcinosis cutis was so severe that it interfered with the movement of his extremities. Both cases responded well to aluminium hydroxide therapy.
Fixed drug eruption to tartrazine
Authors: Orchard David C , Varigos George A 
Published: June 2007

SUMMARYAn 11‐year‐old girl with a recurrent fixed drug eruption to tartrazine on the dorsum of the left hand is presented. Oral provocation tests to both the suspected food, an artificially coloured cheese crisp, and to tartrazine were positive. This case highlights the need to consider artificial flavours, colours and preservatives as potential culprits in classic‘drug eruptions’.
Rapidly growing cutaneous tumour of the right temple: Orf
Authors: Mayet Anton , Sommer Boris , Heenan Peter 
Published: June 2007

SUMMARYA typical lesion of orf developed on the temple of a 61‐year‐old man who apparently contracted the infection indirectly. In addition to the classical histological features of epidermal hyperplasia, necrosis, ballooning and vesical formation, the lesion also showed florid pseudoneoplastic vascular proliferation and a prominent component of eosinophils in the dermal inflammation.
Bindii dermatitis
Authors: Hogan Peter A 
Published: June 2007

SUMMARYBindii dermatitis is a distinctive eruption involving the palms, soles, elbows and knees. Most patients are young boys engaged in vigorous outdoor activities. The eruption represents a reaction to traumatic impregnation of the skin with the spine of the bindii seed. It can easily be misdiagnosed by dermatologists unfamiliar with the condition.
Hirsutes I: Diagnosis
Authors: Young Richard , Sinclair Rod 
Published: June 2007

SUMMARYHirsutes, the coarse, androgen‐dependent growth of hair in women, is a common problem faced by doctors. Whether a woman presents to a clinician or not depends on cultural and racial factors. The clinician must differentiate normal biological variation from cases of hirsutes. In the vast majority of cases, androgen excess is only found locally at the level of the hair follicle; that is, the hirsutism is idiopathic. Important causes of androgen excess, such as an ovarian tumour, need to be excluded. Part one describes the causes of hirsutism and how to differentiate them using history, examination and investigation.
Epidemic cutaneous sporotrichosis: Report of 16 cases in Queensland due to mouldy hay
Authors: Conias Samantha , Wilson Perry 
Published: June 2007

SUMMARYWe report an epidemic of sporotrichosis in a south‐east Queensland rural community. Sporotrichosis is a fungal infection due to the organism Sporothrix schenckii, typically presenting with cutaneous lesions. Sixteen cases of cutaneous sporotrichosis were seen over a 9 month period in the Darling Downs region of Queensland. All patients had had contact with a batch of mouldy hay presumed to be contaminated by Sporothrix schenckii. Nine of 16 patients were male; the youngest patient was aged 11 and the oldest was 67 years of age. Lymphocutaneous sporotrichosis was seen in 50% of patients; the rest demonstrated the fixed cutaneous form. No cases of disseminated cutaneous or systemic sporotrichosis were seen. One case demonstrated lymphangitis related to sporotrichosis. No apparent difference in the duration to diagnosis was demonstrated to exist between lymphocutaneous or fixed cutaneous types.
Epidermolysis bullosa acquisita in childhood
Authors: Su John C , Varigos George A , Dowling John 
Published: June 2007

SUMMARYThis case report of an 11‐year‐old girl describes a juvenile form of epidermolysis bullosa acquisita, an autoimmune disease of IgG antibodies to basement membrane type 7 collagen. Our case illustrates an unusually severe, acute inflammatory presentation of this condition with prominent mucosal and constitutional features requiring admission to a paediatric burns unit. The treatment consisted of supportive topical and systemic agents, prednisolone and dapsone. She responded to dapsone alone and the course of the illness was uneventful.
Pellagra in a woman using alternative remedies
Authors: Wood Blair , Rademaker Marius , Oakley Amanda , Wallace Janelle 
Published: June 2007

SUMMARYA young woman presented with pellagra. Dietary intake of niacin was in excess of recommended guidelines. She had a low body mass index and was taking a number of alternative remedies. Resolution was rapid with oral nicotinic acid and discontinuation of the remedies.
Treatment of cutaneous Bowen's disease with particular emphasis on the problem of lower leg lesions
Authors: Ball Sally B , Dawber Rodney PR 
Published: June 2007

SUMMARYBowen's disease has a particular predilection for the lower leg, especially in women. A review of the literature for treating Bowen's disease is presented and the problems associated with treating the lower leg emphasized. Evidence for the various treatment modalities used to treat Bowen's disease largely comes from studies that lack good methodology in terms of standardized techniques, patient controls and adequate follow‐up. In particular the widely accepted recommendation for excision is not supported by evidence that this treatment is superior to other modalities. The choice of treatment for Bowen's disease should take into account the patient's general condition, the site and size of the lesion.
Allergic contact dermatitis to ethoxyquin in a farmer handling chicken feeds
Authors: Rubel Diana M , Freeman Susanne 
Published: June 2007

SUMMARYFarm workers handling animal feeds are exposed to a variety of chemicals, some of which may cause allergic contact dermatitis. A case of allergy to ethoxyquin (a preservative added to chicken feed to inhibit vitamin degradation) in a chicken farmer is presented. Although the offending allergen was identified in this patient, it proved difficult to find ethoxyquin free chicken feed products and the patient's dermatitis persisted. When facing the clinical problem of dermatitis in animal workers, the possibility of allergic contract dermatitis to components in animal feeds must be considered.
Concurrent infection due to Shewanella putrefaciens and Mycobacterium marinum acquired at the beach
Authors: Papanaoum Kelly , Marshmann Gillian , Gordon Lynette A , Lumb Richard , Gordon David L 
Published: June 2007

SUMMARYInfection with marine bacteria is uncommon. A patient with systemic lupus erthematosus who developed concurrent infection with shewanella putrefaciens and Mycobacterium marinum (M. marinum) is described. After bathing leg ulcers in sea water, severe cellulites of the left leg with necrotic areas and extensive bullae developed. Infection due to S. putrefaciens was confirmed and a long course of hospitalization, oral ciprofloxacin and skin grafting was required. During hospitalization, oral ciprofloxacin and skin grafting was required. During hospitalization subcutaneous nodules developed on the other leg. Biopsy revealed acid‐fast bacilli and culture grew M. marinum. These lesions responded to rifampicin and cotrimoxazole. Patients with leg ulcers, peripheral vascular disease, diabetes, or receiving immunosuppressive drugs may acquire unusual infections after salt water exposure.
Antineutrophil cytoplasmic antibody (ANCA)‐positive cutaneous leucocytoclastic vasculitis associated with antithyroid therapy in Graves' disease
Authors: Miller Robert M , Savige Judy , Nassis Labrini , Cominos Belle I 
Published: June 2007

SUMMARYPresented is a case of a 27‐year‐old male with Graves' disease on long‐term proepylthiouracil treatment who, when changed to carbimazole, rapidly developed a petechial and purpuric eruption on the legs, which subsequently flared on treatment with radioiodine. The clinical diagnosis of leucocytoclastic vasculitis was confirmed on skin biopsy. High‐titre antineutrophil cytoplasmic antibodies in a perinuclear pattern (P‐ANCA) were identified. No anti‐myeloperoxidase activity was noted; therefore, the P‐ANGA were classified in the atypical group. The target antigens, as determined by enzyme‐linked immunosorbent assay, were lysozyme, lactoferrin and bactericidal/permeability increasing protein. Propylthiouracil and carbimazole are chemically related antithyroid drugs. There are reports of typical and atypical P‐ANCA ‐positive cutaneous vasculitis due to propylthiouracil. Cutaneous vasculitis associated with atypical P‐ANCA has not been noted previously to be temporally related to carbimazole use. The consideration of thionamides as possible aetiological agents in cases of P‐ANCA‐positive druginduced vasuculitis is suggested.
Partial face‐sparing lipodystrophy (Köbberling‐Dunnigan syndrome): Report of a sporadic case
Authors: Tain Mei Mui , Berger Peter 
Published: June 2007

SUMMARYA sporadic case is presented of a 20‐year‐old female with partial face‐sparing lipodystrophy, also know as the köbberling‐Dunuigan syndrome with the Type 1 clinical plienotype. This disorder affects the limbs and spares the face. The trunk is spared in the Type 1 phenotype hut is affected in the Type 2 phenotype. The patient had the associated features of this syndrome including hyperinsulinaemia. acanthosis nigricans and mildly raised triglycerides, but not diabetes mellitus.
Adult cutaneous Langerhans cell histiocytosis
Authors: Conias Samantha , Strutton Geoffrey , Stephenson Graham 
Published: June 2007

SUMMARYA 24‐year‐old male presented with a 4 year history of a crusted erythematous popular eruption of the scalp and external auditory meati and a 12 month history of painful perianal ulceration. A diagnosis of Langherhans cell histiocytosis was made and confirmed by skin histology. Extensive investigation revealed no systematic involvement. Rapid improvement occurred after intravenous 2‐chlorodeoxyadenosine but relapse of perianal lesions occurred within 3 months. Local radiotherapy to the perianal region resulted in a complete remission sustained over 12 months.
Idiopathic multiple miliary osteomas of the face
Authors: Novak Csilla , Siller Greg , Wood Dominic 
Published: June 2007

SUMMARYA case of multiple military osteomas of the face arising In a 43‐year‐old Caucasian female with no history of Skin disease is reported Spontaneous development of Numerous asymptomatic, skin‐ coloured facial papules Had occurred over a 3 year period. Originally described In association with long standing acne vulgaris, Multiple military osteomas of the face has recently been Reported in patients without prior skin disease. The Pathogenesis, classification and treatment of this rare Condition are discussed.
Variable presentation of parvovirus B19 in a family
Authors: Leahy Sean T , Marshman Gillian 
Published: June 2007

ABSTRACTThis case report of the sequential presentation of parvovirus B19 in a family deseribes a 38‐year‐oid woman initially presenting with gloves and socks' syndrome; along with her husband and five children who also were affected. A high clinical attack fate with. prolonged illness and/unable clinical presentations was demonstrated, including polyarthritis, erythema infectiosum and symptoms of a respiratory tract infection. In addition, the range of syndromes and clinical features of parvovirus B19 are presented.
A continuum of neutrophilic disease occurring in a patient with ulcerative colitis
Authors: Salmon P , Rademaker M , Edwards L 
Published: June 2007

SUMMARYA case of Sweet's syndrome (acute febrile neutrophilic dermatosis) occurring concurrently with bullous pyoderma gangrenosum is reported to emphasize the close relationship between these two disorders, Aiypical pyoderma gangrenosum and Sweet's syndrome have been described as occurring simultaneously in haematological) dyscrasias but not. to our knowledge, in ulcerative colitis. It has been proposed that pyoderma gangrenosum,; Sweet's syndrome, erythema elevatum diutinum and. subcorneal pustular dermatosis may represent manifestations along a continuum of neutrophilic dermatoses.
Hirsutes II: Treatment
Authors: Young Richard , Sinclair Rod 
Published: June 2007

SUMMARYThe treatment of hirsutes includes cosmetic measures, such as bleaching, plucking, electrical epilation and, more recently, laser epilation. Pharmacological therapy consists of anti‐androgens and includes the androgen receptor blockers spironolactone and eyproterone acetate. Other drugs reducing androgen expression include oral contraceptives and corticosteroids. A new follicular 5α reductase inhibitor, finasteride, is currently under evaluation, as is the anti‐androgen flutamide. Gonadotroph in ‐releasing hormone agonists reduce androgen expression and show early promise in the treatment of hirsutes.
Axillary granular parakeratosis
Authors: Kossard Steven , White Anthony 
Published: June 2007

SUMMARYA 54‐year‐old woman had a 3year history of a recurrent bilateral axillary rash during the summer months. Both axillae showed hyperkeratolic, fissured and cobblestone plaques. Skin biopsy showed the histology previously defined as axillary granular parakeratosis. This finding may indeed represent an unusual contact reaction In anti‐perspirants interfering with epidermal keratinization.
Acquired scalp alopecia. Part I: A review
Authors: Sullivan John R , Kossard Steven 
Published: June 2007

SUMMARYIn this two‐part series we review the acquired scalp alopecias. A broad spectrum of diseases result in alopecia. In this first part we provide a framework for the assessment and diagnosis of scalp hair loss, and begin covering the individual conditions. The non‐scarring alopecias covered include effluvium, andro‐genetic alopecia, alopecia areata, trichotillomania, and loose anagen syndrome. The scarring alopecias cause permanent pilosebaceous follicle loss; the lymphocyte‐associated scarring alopecia described encompasses lichen planopilaris, discoid lupus erythematosus, pseudopelade, and follicular mucinosis. Part II will cover the neutrophil‐associaled and infiltrative processes causing scarring alopecia followed by the medical management of alopecia. There is particular reference to newly described conditions and progress in the understanding of older conditions. More recently characterized conditions include the loose anagen syndrome, chronic telogen effluvium, and the frontal fibrosing variant of lichen planopilaris.
A review of the epidemiology of psoriasis vulgaris in the community
Authors: Plunkett Anne , Marks Robin 
Published: June 2007

SUMMARYStandard diagnostic criteria for epidemiological studies of psoriasis are currently lacking. In their absence, clinical examination and diagnosis of psoriasis by dermatologists provides the gold standard to underpin epidemiological research in psoriasis. The methods of data collection used most frequently include cross‐sectional studies, case‐control studies, cohort studies, and surveys of hospital and private practice attendance. Estimates of psoriasis prevalence made in cross‐sectional studies employing clinical examinations as the survey instrument have ranged from 0.3 to 2.5%. Psoriasis incidence has been estimated at 60.4 per 100 000 person years in one cohort study. Several factors have been identified as being associated either with causation of psoriasis or with triggering exacerbations or remissions, including genetic determinants, racial and regional variation, injury and infection, cigarette smoking, alcohol, diet and other diseases.
Familial Kaposi's sarcoma and Paget's disease of bone
Authors: Hale Lloyd R , Kelly John VV 
Published: June 2007

SUMMARYFamilial Kaposi's sarcoma and familial Paget's disease of bone have not previously been reported to occur in the one patient or the one family. We report on an 82‐year‐old female of Lebanese descent who was recently diagnosed with Kaposi's sarcoma and Paget's disease. Of the patient's eight siblings, seven had Paget's disease and two of these also had Kaposi's sarcoma. Histocompatibility leucocyte antigen (HLA) class I and II typing of the patient showed: A2, A3; B35, Bx; Bw6; Cw4; DRβ1*1101 (an HLA‐DR5 subtype) DRβ3 and DQβ1*0301. Previous reports have described possible associations of familial Kaposi's sarcoma with HLA‐DR5 and Paget's disease with DR2, DRβ1*1104, DPβ1*04and DQw1. Genetic factors and possible viral aetiologies fur each condition are reviewed.
Pretibial myxoedema presenting as a scar infiltrate
Authors: Tong David W , Ho Kenneth K 
Published: June 2007

SUMMARYA 41‐year‐old man developed pretibial myxoedema localized to soars following treatment for hyperthyroidism. Pre‐existing scars on both lower legs, present for more than 20 years, were infiltrated with firm and nonpitting nodules and plaques over his shins. The clinical presentation of this patient highlights pretibial myxoedema as a cause of scar infiltration. The pathogenesis or pretibial myxoedema is reviewed.
Auricular ossification
Authors: Yeatman Josephine M , Varigos George A 
Published: June 2007

SUMMARYA patient with extensive bilateral auricular ossification presented with chondrodermatitis nodularis helicis on one side. The condition was otherwise asymptomatic. Ossification was delected on radiological and histological examination. Underlying medical conditions were nut Pound. We believe this developed as a eon‐sequence of cold injury. Auricular ossification is an unusual cause of the so‐called petrified external ear, in which the subcutaneous tissue is stony hard, it is more commonly caused by dystrophic calcification. Calcification and ossification are clinically identical and histological examination is required to definitively differentiate them.
Acquired self‐healing Blaschko dermatitis in an adult
Authors: Betti Roberto , Vergani Raffaella , Gualandri Lorenzo , Crosti Carlo 
Published: June 2007

SUMMARYA 24‐year‐old woman with a 3 year history of Blasehkitis is presented. The dermatosis consisted of erythematous vesicular papules following Blasehko's lines on her left trunk. A moderate itching was described by the patient initially. Resolution occurred spontaneously after 3 months with hypopigmentation. Histological examination demonstrated a perivascular inflammatory infiltrate in the subpapillary dermis with lymphocytic exocytosis.
Desmoplastic trichoepithelioma
Authors: Zuccati Giuliano , Massi Daniela , Mastrolorenzo Antonio , Urbano Francesco G , Paoli Simone , Reali Umberto M 
Published: June 2007

SUMMARYA 20‐year‐old male presented with a 4 year history of a solitary nodule, 8 mm in diameter on the left temple. It was covered by normal skin, with a central depression and elevated borders. Histopathology showed numerous born cysts amidst nests and strands of basaloid cells surrounded by a dense fibrous stroma. The clinical and histopathological features were characteristic of desmoplastic trichoepithelioma.
Are non‐absorbable indicators of comparable value in the human stomach made abnormal by taurocholic acid?
Authors: Ivey K. J. , Parsons C. 
Published: June 2007

SUMMARY1. The substances chromium‐51 (51CrCl3) and phenolsulphonphthalein (phenol red; PR) were compared as non‐absorbable indicators in the human stomach after alteration of ionic permeability by taurocholic acid.2. Control and test solutions containing 10 mm taurocholic acid and indicators at pH 1 were instilled into the stomach and sampled immediately and after 15 min. The ratios of the initial and final concentrations of the indicators (Ci/Cf) were compared.3. Correlation coefficients of the Ci/Cf ratios for the two indicators were 0·91 in control studies and 0·75 after taurocholic acid instillation; there was no significant difference between either indicator. During taurocholic acid instillation, Ci/Cf values tended to fall compared to controls.4. In a smaller number of subjects in whom polyethylene glycol (PEG) was also measured as a non‐absorbable indicator, results were similar to those obtained with 51Cr and PR.5. 51Cr, PR and PEG are comparable indicators in the normal human stomach and when it is made abnormal by a lipid‐soluble agent such as unionized taurocholic acid, though the correlation between indicators is reduced in the abnormal stomach.6. No evidence of increased absorption of any indicator was found in spite of the increased ionic permeability produced by taurocholic acid.
Pressure‐flow relationships in the peripheral circulation of the dog with isoprenaline
Authors: Green Jerry Franklin 
Published: June 2007

SUMMARY1. The effects of isoprenaline on the pressure‐flow relationships in the peripheral circulation were studied in five anaesthetized dogs during right heart bypass procedures.2. Isoprenaline (1 μg/kg per min) produced a significant drop in arterial pressure and arterial resistance.3. There was a significant decrease in the resistance to venous return which resulted in a significant increase in venous return.4. The findings suggest that the increase in cardiac output produced by isoprenaline results in large part from dilatation of venous resistance vessels.
Structural requirements for angiotensin analogues to accumulate cyclic AMP and release vasopressin from the incubated rat neurohypophysis
Authors: Gagnon D. J. , Sirois P. , Park W. K. 
Published: June 2007

SUMMARY1. Angiotensin I, a decapeptide, stimulated the accumulation of cyclic 3',5'‐AMP (cyclic AMP) and the release of vasopressin from incubated rat neurohypophyses.2. Various octapeptides related to angiotensin II were capable of producing similar neurohypophyseal effects.3. Longer incubation periods were needed with peptides having alterations or omission (e.g. heptapeptide 2–8) at position 1 of the parent molecule to evoke similar effects to those of angiotensin II.4. Our results suggest strongly that physiological doses of angiotensin‐related molecules stimulate the secretion of vasopressin through cyclic AMP, and that the neurohypophyseal receptor responsible for these effects is similar to that involved in their peripheral actions.
Plasma and tissue iron changes in the rat after acute administration of ethionine
Authors: Loh T. T. , Archdeacon J. W. 
Published: June 2007

SUMMARY1. Ethionine administered acutely to the adult female rat markedly elevates and then lowers plasma iron concentration over several days. Liver iron undergoes a reverse cycle.2. Ethionine does not cause changes in the blood parameters, including total plasma iron‐binding capacity and plasma iron clearance. Erythrocytes of rats injected with ethionine show altered responses to hypertonicity.3. Increased reticulo‐endothelial activity of the spleen, indicated by increased uptake of 59Fe‐labelled erythrocytes by liver and spleen, apparently contributes to plasma iron elevation. Also the liver releases iron which further raises plasma iron.