bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tuning the Reaction Site for Enzyme‐Free Primer‐Extension Reactions through Small Molecule Substituents
Authors: Rojas Stütz Jan A. , Richert Clemens 
Published: January 2006

AbstractThe replication of genetic information relies on the template‐directed extension of DNA primers catalyzed by polymerases. The active sites of polymerases accept four different substrates and ensure fidelity and processivity for each of them. Because of the pivotal role of catalyzed primer extension for life, it is important to better understand this reaction on a molecular level. Here we present results from primer‐extension reactions performed with chemical systems that show high reactivity in the absence of polymerases. Small molecular caps linked to the 5′‐terminus of templates are shown to enhance the rate and selectivity of primer extension driven by 2‐methylimidazolides as activated monomers for any of the four different templating bases (A, C, G, and T). The most consistent effect is provided by a stilbene carboxamide residue, rather than larger aromatic or aliphatic substituents. Up to 20‐fold rate enhancements were achieved for the reactions at the terminus of the template. The preference for a medium size cap can be explained by competing interactions with both the oligonucleotides and the incoming deoxynucleotide. The data also show that there is no particularly intractable problem in combining promiscuity with fidelity. Exploratory experiments involving a longer template and a downstream‐binding strand with a 5′‐cap show up to 38‐fold rate acceleration over the same reaction templated by a single overhanging nucleotide.
Protonic and Temperature Modulation of Constituent Expression by Component Selection in a Dynamic Combinatorial Library of Imines
Authors: Giuseppone Nicolas , Lehn Jean‐Marie 
Published: January 2006

AbstractThe constitutional recomposition of a dynamic library of imines displays a complex behavior under the effect of two parameters, acidity and temperature. A qualitative analysis of the quantitative data is presented. The results illustrate the response of such a dynamic system to a physical stimulus (temperature) and a chemical effector (H+), thus demonstrating its adaptive behavior under the pressure of external factors. They also point to the possibility of modulating a given functional property (optical, electronic, ionic) by constitutional recomposition induced by a specific trigger. Such features are of great interest for the development of stimuli‐responsive, functional dynamic materials.
A Fluent Transition from Triiodide, I3−, to Tris(trifluoromethyltellurate)(1−), [(TeCF3)3]−—A Structural Study
Authors: Fischer Hendrik T. M. , Naumann Dieter , Tyrra Wieland 
Published: January 2006

AbstractA complete series of compounds with the anions [(TeCF3)3−xIx]− (x=0–2) had been prepared and characterised in the solid state and by NMR spectroscopic methods. Dynamic behaviour in solution can be assumed for [(TeCF3)3]− and [(TeCF3)2I]−, while in the solid state all three bis(triphenylphosphoranyliden)ammonium (PNP) salts resemble structures found in triiodides. The molecular structures of [PNP][(TeCF3)3−xIx]− (x=0–2) are discussed in comparison with [PNP]I3, I2, and Te2(CF3)2. On this basis, the structures of the [(TeCF3)3]− and [(TeCF3)I2]− ions are comparable to symmetric I3− ions, while the [(TeCF3)2I]− ion resembles an asymmetric I3− unit.
Investigation of LaMn2‐xFexSi2 (0 ≤ x ≤ 1.2) by Magnetic Measurements and Neutron Diffraction.
Authors: Dincer I. , Elmali A. , Elerman Y. , Ehrenberg H. , Fuess H. , Daoud‐Aladine A. 
Published: January 2006

AbstractFor Abstract see ChemInform Abstract in Full Text.
Systematic Study of Formation and Crystal Structure of 3d‐Transition Metal Nitrides Synthesized in a Supercritical Nitrogen Fluid under 10 GPa and 1800 K Using Diamond Anvil Cell and YAG Laser Heating.
Authors: Hasegawa Masashi , Yagi Takehiko 
Published: January 2006

AbstractFor Abstract see ChemInform Abstract in Full Text.
High‐Temperature, High‐Pressure Hydrothermal Synthesis, Crystal Structure, and Luminescence Properties of Cs3EuSi6O15, a New Europium(III) Silicate with a Three‐Dimensional Framework Structure.
Authors: Huang Meow‐Yu , Chen Yi‐Hsiu , Chang Bor‐Chen , Lii Kwang‐Hwa 
Published: January 2006

AbstractFor Abstract see ChemInform Abstract in Full Text.
2,6‐Dicarboxypyridinium Fluorochromate: A Mild and Efficient Reagent for Oxidative Deprotection of Trimethylsilyl Ethers to Their Corresponding Carbonyl Compounds.
Authors: Hosseinzadeh Rahman , Tajbakhsh Mahmood , Ramzanian‐Lehmali Farhad , Sadatshahabi Marzieh 
Published: January 2006

AbstractFor Abstract see ChemInform Abstract in Full Text.
An Efficient Stereoselective Synthesis of 4,5‐trans‐1,5‐cis‐3‐Oxabicyclo[3.1.0]hexan‐2‐ones via the Iodolactonization of Alkylidenecyclopropyl Esters.
Authors: Ma Shengming , Lu Lianghua 
Published: January 2006

AbstractFor Abstract see ChemInform Abstract in Full Text.
An Efficient Synthesis of 5‐Silyl‐2,3‐dihydrofurans via Acid‐Catalyzed Ring‐Enlargement of Cyclopropyl Silyl Ketones and Their Functionalization.
Authors: Honda Mitsunori , Naitou Tomoyuki , Hoshino Hiromitsu , Takagi Seiji , Segi Masahito , Nakajima Tadashi 
Published: January 2006

AbstractFor Abstract see ChemInform Abstract in Full Text.
High‐Temperature Synthesis of Thiophene from Bis(2‐chloroethyl) Sulfide.
Authors: Voronkov M. G. , Levanova E. P. , Sukhomazova E. N. , Russavskaya N. V. , Deryagina E. N. , Korchevin N. A. 
Published: January 2006

AbstractFor Abstract see ChemInform Abstract in Full Text.
Novel Indole α‐Methylene‐γ‐lactones as Potent Inhibitors for AKT‐mTOR Signaling Pathway Kinases.
Authors: Ding Huasheng , Zhang Chao , Wu Xihan , Yang Chunhao , Zhang Xiongwen , Ding Jian , Xie Yuyuan 
Published: January 2006

AbstractFor Abstract see ChemInform Abstract in Full Text.
Palladium‐Catalyzed Amination and Amidation of Benzo‐Fused Bromine‐Containing Heterocycles.
Authors: Sergeev A. G. , Artamkina G. A. , Velezheva V. S. , Fedorova I. N. , Beletskaya I. P. 
Published: January 2006

AbstractFor Abstract see ChemInform Abstract in Full Text.
Novel 3,4‐Diarylpyrazolines as Potent Cannabinoid CB1 Receptor Antagonists with Lower Lipophilicity.
Authors: Lange Jos H. M. , van Stuivenberg Herman H. , Veerman Willem , Wals Henri C. , Stork Bob , Coolen Hein K. A. C. , McCreary Andrew C. , Adolfs Tiny J. P. , Kruse Chris G. 
Published: January 2006

AbstractFor Abstract see ChemInform Abstract in Full Text.
Versatile Access to C‐4‐Substituted 2‐Amino‐1,3‐azoles from Hydropyridines in Oxidative Conditions.
Authors: del Rayo Sanchez Salvatori Maria , Abou‐Jneid Robert , Ghoulami Said , Martin Marie‐Therese , Zaparucha Anne , Al‐Mourabit Ali 
Published: January 2006

AbstractFor Abstract see ChemInform Abstract in Full Text.
New Tandem Reactions of Metal Carbenoids. Intermolecular Formation of Azomethine Ylide from Methyl 2‐Diazo‐2‐phenylacetate and Schiff Base: Intramolecular 1,3‐Dipolar Cycloaddition.
Authors: Khlebnikov A. F. , Novikov M. S. , Bespokoev A. A. , Kostikov R. R. , Kopf J. , Starikova Z. A. , Antipin M. Yu. 
Published: January 2006

AbstractFor Abstract see ChemInform Abstract in Full Text.
Ring‐Closing Metathesis for the Synthesis of 2H‐ and 4H‐Chromenes.
Authors: van Otterlo Willem A. L. , Ngidi E. Lindani , Kuzvidza Samuel , Morgans Garreth L. , Moleele Simon S. , de Koning Charles B. 
Published: January 2006

AbstractFor Abstract see ChemInform Abstract in Full Text.
Thiophene‐Fused Quinoline Analogues: Facile Synthesis of 3‐Amino‐2‐cyanothieno[2,3‐b]quinolines from 2‐Chloro‐3‐cyanoquinolines.
Authors: Srivastava Ambika , Chandra Atish , Singh R. M. 
Published: January 2006

AbstractFor Abstract see ChemInform Abstract in Full Text.
An Efficient Protocol for the Synthesis of Quinoxaline Derivatives at Room Temperature Using Molecular Iodine as the Catalyst.
Authors: Bhosale Rajesh S. , Sarda Swapnil R. , Ardhapure Suresh S. , Jadhav Wamanrao N. , Bhusare Sudhakar R. , Pawar Rajendra P. 
Published: January 2006

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis of Chiral Nonracemic Polyimine Macrocycles from Cyclocondensation Reactions of Biaryl and Terphenyl Aromatic Dicarboxaldehydes and (1R,2R)‐Diaminocyclohexane.
Authors: Kuhnert Nikolai , Patel Chirag , Jami Fatemeh 
Published: January 2006

AbstractFor Abstract see ChemInform Abstract in Full Text.
Microwave‐Assisted One‐Pot Synthesis of 8‐Methyl‐3,6,9‐triphenyl‐5,6‐dihydro‐9H‐pyrazolo[3,4‐e][1,2,4]triazolo [3,4‐b][1,3,4]thiadiazepine.
Authors: Nandeshwarappa B. P. , Kumar D. B. Aruna , Naik H. S. Bhojya , Vaidya V. P. , Mahadevan K. M. 
Published: January 2006

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis and Bioactivity of Some New 2‐Substituted‐3,4‐dihydro‐3‐(3′‐chloro‐4′‐fluorophenyl)‐2H‐ [1,3,2]benzoxazaphosphorin 2‐Oxides.
Authors: Kiran Y. B. , Kasthuraiah M. , Nagaraju C. , Gunasekar D. , Babu S. V. S. Madhu , Reddy C. Devendranath 
Published: January 2006

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis and Evaluation of 3‐Anilino‐quinoxalinones as Glycogen Phosphorylase Inhibitors.
Authors: Dudash Joseph Jr. , Zhang Yongzheng , Moore John B. , Look Richard , Liang Yin , Beavers Mary Pat , Conway Bruce R. , Rybczynski Philip J. , Demarest Keith T. 
Published: January 2006

AbstractFor Abstract see ChemInform Abstract in Full Text.
2‐(2‐Furanyl)‐7‐phenyl[1,2,4]triazolo[1,5‐c]pyrimidin‐5‐amine Analogues as Adenosine A2A Antagonists: The Successful Reduction of hERG Activity. Part 2.
Authors: Matasi Julius J. , Caldwell John P. , Zhang Hongtao , Fawzi Ahmad , Higgins Guy A. , Cohen‐Williams Mary E. , Varty Geoffrey B. , Tulshian Deen B. 
Published: January 2006

AbstractFor Abstract see ChemInform Abstract in Full Text.
1‐(4‐Amino‐phenyl)‐pyrrolidin‐3‐yl‐amine and 6‐(3‐Amino‐pyrrolidin‐1‐yl)‐pyridin‐3‐yl‐amine Derivatives as Melanin‐Concentrating Hormone Receptor‐1 Antagonists.
Authors: Zhu Yun‐Fei , et al. et al. 
Published: January 2006

AbstractFor Abstract see ChemInform Abstract in Full Text.
Identification of a Potent and Selective 5‐HT1B Receptor Antagonist.
Authors: Wyman Paul A. , Marshall Howard R. , Flynn Sean T. , King Ron J. , Thompson Mervyn , Smith Paul W. , Hadley Michael S. , Price Gary W. , Scott Claire M. , Dawson Lee A. 
Published: January 2006

AbstractFor Abstract see ChemInform Abstract in Full Text.
N‐Arylalkanamides, Ynamides, Enamides, Dienamides, and Allenamides
Authors: Tracey M. R. , Hsung R. P. , Antoline J. , Kurtz K. C. M. , Shen L. , Slafer B. W. , Zhang Y. 
Published: January 2006

AbstractFor Abstract see ChemInform Abstract in Full Text.
Enhanced viral and tumor immunity with intranodal injection of canary pox viruses expressing the melanoma antigen, gp100
Authors: Spaner David E. , Astsaturov Igor , Vogel Thorsten , Petrella Teresa , Elias Ileana , Burdett‐Radoux Susan , Verma Shailendra , Iscoe Neill , Hamilton Paul , Berinstein Neil L. 
Published: January 2006

AbstractBACKGROUNDThe route of administration and extent of helper T‐cell activation are factors that are likely to be important for the development of effective cancer vaccines. In order to optimize CD8+ cytotoxic T‐lymphocyte (CTL) responses, the immunologic effects of direct lymph node (LN) injections of canary pox virus (ALVAC) vectors (expressing the melanoma antigen, gp100) and immunogenic gp100 peptides, along with concomitant injections of the helper adjuvant, tetanus toxoid, were studied in high‐risk HLA‐A*0201+ patients.METHODSForty‐two patients were vaccinated using six different protocols. Twenty‐three patients were ‘primed’ with ALVAC(2)‐gp100m and ‘boosted’ with gp100 peptides, either subcutaneously or into an LN. Intranodal (IN) peptides, alone, were administered to six patients. Thirteen patients were given tetanus toxoid initially, and with each gp100 vaccination. Toxicity was recorded and immunologic responses were determined in 35 patients by enzyme‐linked immunospot (ELISPOT) and gp100‐tetramer binding assays and anti‐ALVAC(2) enzyme‐linked immunosorbent assays (ELISAs).RESULTSAll vaccine protocols were tolerated well. Using stringent criteria for immunologic response, 8 of 18 patients responded to the viral vaccines, in striking contrast to peptides only (0 of 6 patients) or with help in trans from tetanus‐reactive T‐cells (1 of 11 patients). Changes in gp100‐reactive CTL frequencies and ALVAC antibodies were greatest when viruses were injected directly into LNs.CONCLUSIONSIN injections of ALVAC(2)‐gp100m viruses are feasible, safe, and may be a superior method of vaccination in humans. CTL responses to this vaccine were not enhanced by tetanus toxoid. Cancer 2006. © 2006 American Cancer Society.
K‐ras mutations and N‐ras mutations in childhood acute leukemias with or without mixed‐lineage leukemia gene rearrangements
Authors: Liang Der‐Cherng , Shih Lee‐Yung , Fu Jen‐Fen , Li Huei‐Ying , Wang Hsiu‐I , Hung Iou‐Jih , Yang Chao‐Ping , Jaing Tang‐Her , Chen Shu‐Huey , Liu Hsi‐Che 
Published: January 2006

AbstractBACKGROUNDIt is believed that Ras mutations drive the proliferation of leukemic cells. The objective of this study was to investigate the association of Ras mutations with childhood acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) with special reference to the presence or absence of mixed‐lineage leukemia gene (MLL) rearrangements.METHODSBone marrow samples from 313 children with B‐precursor ALL and 130 children with de novo AML were studied at diagnosis. Southern blot analysis was used to detect MLL rearrangements, and reverse transcriptase‐polymerase chain reaction (RT‐PCR) analysis was used to detect common MLL fusion transcripts. Complementary DNA panhandle PCR was used to identify the infrequent or unknown MLL partner genes. DNA PCR or RT‐PCR followed by direct sequencing was performed to detect mutations at codons 12, 13, and 61 of the N‐Ras and K‐Ras genes.RESULTSTwenty of 313 patients with B‐precursor ALL and 17 of 130 patients with de novo AML had MLL rearrangements. N‐Ras mutations were detected in 2 of 20 patients with MLL‐positive ALL and in 27 of 293 patients with MLL‐negative ALL (P = 1.000). N‐Ras mutations were detected in 2 of 17 patients with MLL‐positive AML and in 14 of 113 patients with MLL‐negative AML (P = 1.000). K‐Ras mutations were present in 8 of 20 patients with MLL‐positive ALL compared with 32 of 293 patients with MLL‐negative ALL (P = 0.001). K‐Ras mutations were detected in 3 of 17 patients with MLL‐positive AML compared with 5 of 113 patients with MLL‐negative AML (P = 0.069).CONCLUSIONSRas mutations were detected in 20.8% of patients with childhood B‐precursor ALL and in 17.7% of patients with childhood AML. MLL‐positive B‐precursor ALL was associated closely with Ras mutations (50%), especially with K‐Ras mutations (40%), whereas MLL‐positive AML was not associated with Ras mutations. Cancer 2006. © 2006 American Cancer Society.
Vitamin D3 down‐regulates monocyte TLR expression and triggers hyporesponsiveness to pathogen‐associated molecular patterns
Authors: Sadeghi Kambis , Wessner Barbara , Laggner Ute , Ploder Martin , Tamandl Dietmar , Friedl Josef , Zügel Ullrich , Steinmeyer Andreas , Pollak Arnold , Roth Erich , Boltz‐Nitulescu George , Spittler Andreas 
Published: January 2006

AbstractToll‐like receptors (TLR) represent an ancient front‐line defence system that enables the host organism to sense the presence of microbial components within minutes. As inducers of inflammation, TLR act as important triggers of distinct entities such as sepsis or autoimmune disease exacerbation. We report here that vitamin D3 [1α,25‐dihydroxycholecalciferol, 1,25(OH)2D3] suppresses the expression of TLR2 and TLR4 protein and mRNA in human monocytes in a time‐ and dose‐dependent fashion. Despite 1,25(OH)2D3‐induced up‐regulation of CD14, challenge of human monocytes with either LPS or lipoteichoic acid resulted in impaired TNF‐α and procoagulatory tissue factor (CD142) production, emphasizing the critical role of TLR in the induction of inflammation. Moreover, reduced TLR levels in 1,25(OH)2D3‐treated phagocytes were accompanied by impaired NF‐κB/RelA translocation to the nucleus and by reduced p38 and p42/44 (extracellular signal‐regulated kinase 1/2) phosphorylation upon TLR‐ligand engagement. Both TLR down‐regulation and CD14 up‐regulation were substantially inhibited by the vitamin D receptor (VDR) antagonist ZK 159222, indicating that the immunomodulatory effect of 1,25(OH)2D3 on innate immunity receptors requires VDR transcription factor activation. Our data provide strong evidence that 1,25(OH)2D3 primes monocytes to respond less effectively to bacterial cell wall components in a VDR‐dependent mechanism, most likely due to decreased levels of TLR2 and TLR4.
Low‐avidity CD8lo T cells induced by incomplete antigen stimulation in vivo regulate naive higher avidity CD8hi T cell responses to the same antigen
Authors: Maile Robert , Pop Shannon M. , Tisch Roland , Collins Edward J. , Cairns Bruce A. , Frelinger Jeffrey A. 
Published: January 2006

AbstractWe have previously reported that multiple injections of soluble MHC class I tetramers assembled with wild‐type HY peptide induces unresponsiveness to male skin grafts in naive female C57BL/6 (B6) mice. Induction of unresponsiveness is dependent on a population of unresponsive allospecific CD8lo T cells. Reduced expression of CD8 acts to limit a T cell response to HY peptide by limiting the avidity window of effective signal transduction. We and others have demonstrated that CD8lo T cells are an alternative stable phenotype of CD8αβ+ T cells in vitro and in vivo after antigen stimulation. We show here that CD8lo T cells can suppress naive CD8+ T cell responses to HY antigen in vitro and male skin graft rejection in vivo after adoptive transfer into female recipients. These novel regulatory T cells express surface TGF‐β1 and secrete T cytotoxic 2 cytokines after antigen‐specific stimulation. Anti‐TGF‐β antibody and latency‐associated peptide inhibit the suppressive effects in vitro. We also show that HY‐specific memory CD8+ T cells overcome regulation by CD8lo T cells. These data define a novel peripheral regulatory CD8+ T cell population that arises after repeated antigen encounter in vivo. These cells have implications in the maintenance of tolerance and memory.See accompanying commentary http://dx.doi.org/10.1002/eji200535797
The zinc finger protein Gfi1 acts upstream of TNF to attenuate endotoxin‐mediated inflammatory responses in the lung
Authors: Jin Jianmin , Zeng Hui , Schmid Kurt‐Werner , Toetsch Martin , Uhlig Stefan , Möröy Tarik 
Published: January 2006

AbstractGfi1 is a 55‐kD nuclear zinc finger protein that is differentially expressed in lymphoid and myeloid cells. Gfi1–/– mice show a very strong systemic response to the endotoxin LPS and die rapidly within 36 h with symptoms of septic shock. Here we report that the pathohysiological processes for this exaggerated inflammatory response take place in the lung. After LPS treatment, lungs of Gfi1–/– mice showed a rapid accumulation of mononuclear cells and a significant overproduction of inflammatory cytokines such as TNF, IL‐1β and IL‐6. Increased cytokine production was also observed in blood‐free perfused lungs from Gfi1–/– mice exposed to either LPS or overventilation. Alveolar macrophages but not airway epithelial cells from Gfi1–/– mice were found to be responsible for the enhanced cytokine production. Strikingly, when the TNF gene was deleted, Gfi1–/– animals were completely rescued from LPS hypersensitivity and had significantly lower IL‐1β and IL‐6 levels. We conclude that the unrestrained endotoxin response of Gfi1–/– mice occurs mainly in the lung and that Gfi1 represents a novel factor limiting the inflammatory immune response of this organ, and propose that Gfi1 exerts its regulatory function in alveolar macrophages downstream of the LPS receptor (TLR4) and upstream of TNF.
The osteopontin – CD44 pathway is superfluous for the development of autoimmune myocarditis
Authors: Abel Brian , Kurrer Michael , Shamshiev Abdijapar , Marty Rene R. , Eriksson Urs , Günthert Ursula , Kopf Manfred 
Published: January 2006

AbstractOsteopontin (OPN) and CD44 have been implicated in the development of autoimmune diseases, including arthritis and multiple sclerosis, as well as chronic inflammatory diseases, such as atherosclerosis and colitis. To investigate their roles in autoimmune myocarditis induced by immunization with heart alpha‐myosin (MyHC‐α), a mouse model of human cardiomyopathy, we analyzed mice lacking OPN or CD44v6/v7, a CD44 isoform that binds OPN. Both, OPN–/– and CD44v6/v7–/– mice developed myocarditis with the same prevalence and severity as BALB/c wild‐type controls. Furthermore, treatment of BALB/c mice with a pan‐neutralizing anti‐CD44 antibody did not affect the disease outcome. Consistently, expansion of MyHC‐α‐specific autoimmune CD4+ T cells and MyHC‐α autoantibody responses from either CD44v6/v7–/– mice or OPN–/– mice was indistinguishable from their wild‐type controls. Thus, OPN and CD44v6/v7 are merely spectators rather than protagonists in autoimmune myocarditis.
Mono‐ versus Binuclear Copper(II) Complexes in Phosphodiester Hydrolysis
Authors: Selmeczi Katalin , Giorgi Michel , Speier Gábor , Farkas Etelka , Réglier Marius 
Published: January 2006

AbstractMono‐ and dinuclear copper(II) complexes [Cu(L1OH)](CF3SO3)2 (1) and [Cu2(L2O)](CF3SO3)3 (2) have been synthesized and characterized by X‐ray crystallography. Complexes 1 and 2 were then tested as catalysts for the hydrolysis of bis(p‐nitrophenyl)phosphate (BNPP). At pH 6, the dinuclear complex 2 was found to be 20‐fold more active than complex 1 and the reaction up to 600‐fold faster than the un‐promoted reaction. On the basis of potentiometric studies, we were able to demonstrate that the bis(aqua)copper complex was the active species by the formation of a ternary complex in which one copper atom binds to a hydroxide and the second, to the substrate. We also propose that BNPP reacts with the bis(aqua)copper complex to give a stable, hydrolytically inactive BNPP‐2 complex (3). (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)
Absence of Dichroism in Dinuclear Rhenium Complexes with Sterically Hindered μ2‐(η2‐N,O)‐Nitrosobenzene Ligands
Authors: Krinninger Christoph , Wirth Stefan , Klüfers Peter , Mayer Peter , Lorenz Ingo Peter 
Published: January 2006

AbstractThe substitution reactions of [Re(CO)5X] (X = Cl, Br) with 2,6‐dihalo‐substituted nitrosobenzene derivatives C6H2YZ2NO (Y = H, Cl, Br; Z = Cl, Br) leads to the formation of dinuclear μ2‐η2‐N,O‐nitrosobenzene‐bridged complexes of the type [{(CO)3Re(μ‐X)}2ONC6H2YZ2] (6a,b, 7a,b, 8a,b, 9a). The turquoise coloured solutions of the complexes in CH2Cl2 show only one UV/Vis absorption of medium intensity in the region 670–710 nm, depending on the halogen bridges X and substituents Z. Single crystals of the complexes do not exhibit any dichroic properties. This may be due to the almost perpendicular orientation of the phenyl ring towards the Re–O–N–Re plane. The molecular structures of six compounds, as determined by single‐crystal X‐ray analyses, show two face‐joined octahedra with Re centres that are bridged by two halogens X and one NO group. NO coordinates in a nonsymmetrical η2‐like fashion with N‐ or O‐linkage to each Re centre. The phenyl rings do not lie within the symmetry plane containing the atoms Re, N and O, but are almost perpendicular to this (torsion angle O–N–C–C = 83.5–85.4°) because of the 2,6‐dihalogen substituents Z. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)