bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative evaluation of effects of manual and powered tooth brushing on biofilm formation on metal orthodontic brackets and on gingival and periodontal health- an in-vivo study
Authors: Agrawal Surabhi , Chachada Achint , Jain Megha , Golchha Rishabh 
Published: April 2024

To evaluate and compare the effects of manual tooth brushing and powered tooth brushing on biofilm formation on metal orthodontic brackets and on gingival and periodontal health of the patient undergoing orthodontic treatment.This randomized controlled clinical trial comprised a total of 36 patients in the age group 15-25 years, coming to Outpatient Department (OPD) of Orthodontics and Dentofacial Orthopedics and undergoing orthodontic treatment. Periodontal evaluation was performed for each patient at four intervals of time, before oral prophylaxis, 1 week after oral prophylaxis, after 3 months of bonding and after 6 months of bonding which constituted the readings at T, T, T and T, respectively. Patients were instructed to use manual toothbrushes for 3 months after bonding. Post 3 months, the patients were divided into two groups- Group I and II as Group I- patients using powered toothbrush and Group II- patients using manual toothbrush, for next 3 months. At both the intervals (T and T), two brackets were debonded from central incisors and second premolars from each patient and studied under scanning electron microscope for biofilm formation.Powered toothbrushing was more effective in reducing API and SBI scores, statistically high significant difference was seen in API score (P = .004) and SBI score (P &#60; .001) between T & T time intervals on comparing both the groups. Both the manual and powered toothbrushing had equal effect on GI scores, no significant difference was seen in GI score (P = .540) between T & T time intervals on comparing both the groups. On inter group comparison of amount of biofilm formation between T2 & T3 time intervals in anterior and posterior region, higher amount of biofilm formation in both the anterior and posterior regions in group II patients (Anterior region= 12.05±6.90, P = .001, posterior region= 10.32±9.75, P = .001).Powered toothbrushes are more effective in removing plaque and thus reducing gingival inflammation in patients with fixed orthodontic appliances.
Determination of the position of impacted maxillary canine – A panoramic radiographic study
Authors: Shah Deep , Parikh Shilpa , Shah Setu P , Verma Oshin , Shah Shailja , Patel Purv 
Published: April 2024

Maxillary canines are one of the most common impacted teeth. The objective in localization of an impacted canine is to be able to decide such a radiographic technique which has minimal radiation dose, cost and minimum superimpositions. Panoramic radiograph, being a screening radiograph, can satisfy the above needs. Taking this into consideration, the present study was done to evaluate the reliability of panoramic radiograph in localization of impacted permanent maxillary canines, when compared to cone-beam computed tomography.OPG and CBCT images of 100 maxillary impacted canines were included in the study irrespective of site. Each OPG was evaluated for vertical angulation and the data obtained was tabulated and subjected to statistical analysis.In the present study, the female to male ratio was 2.57:1, with a slightly higher prevalence of impacted maxillary canines on left side. The results of the present study show a 100% concordance between OPG and CBCT for palatal and buccal impactions, and 91% for mid-alveolus impactions.Based on the results of the present study, it may be concluded that panoramic radiographs are useful for predicting the location of impacted maxillary canines against the confirmatory radiographic modality like CBCT.
Zaangażowanie środowiska teatralnego w sprawy publiczne w okresie od czerwca 1989 do grudnia 1990 roku. Rekonesans
Authors: Brzuszczak Przemysław 
Published: April 2024

Artykuł podejmuje problematykę zaangażowania środowiska teatru w sprawy publiczne w okresie od wyborów czerwcowych i poprzedzającej je kampanii wyborczej do upadku rządu Tadeusza Mazowieckiego w grudniu 1990 r. Środowiskowi liderzy opinii gremialnie poparli kierunek transformacji systemowej zaproponowany przez rząd „naszego premiera”. Starzy mistrzowie (Gustaw Holoubek, Andrzej Łapicki, Andrzej Szczepkowski, Andrzej Wajda) wystartowali spod szyldu „Solidarności” w wyborach czerwcowych, zaś I. Cywińska – dyrektorka kontestatorskiego Teatru Nowego w Poznaniu – została ministrem kultury i sztuki w gabinecie Mazowieckiego. Czołowe postaci życia teatralnego były zwolennikami tak samego premiera, jak i jego zaplecza politycznego. W artykule uwypuklono przejawy działalności publicznej ludzi sceny, służące do tego środki wyrazu czy też fora, gdzie taką praktykowano. Środowisko teatralne, przyzwyczajone do stylistyki teatru aluzyjnego — tak specyficznej dla PRL, nie do końca umiało odszukać się w warunkach rodzącej się demokracji liberalnej.
Identification of Indigenous Lactobacillus fermentum by 16S rRNA Gene Sequencing Isolated from Two Different Ecosystems: Newborn Infants and Bee’s Intestine
Authors: Bahloul H.A. , Bekenniche N. , Zeriouh I.F. , Hadadji M. , Kihal M. 
Published: April 2024

Background: The consumption of functional ferments that have functional characteristic sand contributes enormously to the safety and quality of food by offering several nutritional, technological and health properties. Lactobacillus fermentum (Lb. fermentum) is a Gram-positive bacterium belonging to the genus Lactobacillus and many are said to have the effect of preventing gastro-intestinal infections and improving immunological response. Additionally, Lb. fermentum produces diverse and potent antimicrobial peptides which can be applied as alternatives to antibiotics. Methods: In this study, samples were isolated from two different ecological niches, the first was feces of newborn infants (0-3 months) and the second from bee’s intestine, from south of Algeria : Ghardaïa 32°29'00" North, 3°41'00" East. Two indigenous lactic acid bacteria were isolated and evaluated for their probiotic properties. The isolate identification by sequencing 16S r DNA was performed using the universal primers 27F and 1492R. The NCBI Gen Bank database was used to have similarity of species. Result: The cultures showed good survival in simulated transit fluids as well as high acid and bile tolerance. The isolates also demonstrated antibacterial activity against Escherichia coli and Staphylococcus aureus, the inhibition zone was measured between 10 mm and 20 mm of diameter respectively. Comparing the sequences of the isolates with the Gen Bank database (NCBI), a high percentage with species of Lactobacillus fermentum was shown.
The peri / postoperative analgesic effect of intravenous paracetamol in dogs
Authors: Mckay Laura 
Published: April 2024

PICO Question
In healthy dogs undergoing a surgical procedure, is there improved pain control in dogs receiving intravenous paracetamol in the peri / postoperative period compared to dogs not receiving intravenous paracetamol?

Clinical bottom line
Category of research
Treatment.
Number and type of study designs reviewed
Three randomised, controlled, and blinded studies. Two studies directly address the PICO question whereby postoperative pain assessment was clinically evaluated following intravenous (IV) paracetamol. The third study addressed the question to a lesser extent, whereby the impact on the sevoflurane minimum alveolar concentration (MAC) reduction in response to noxious stimuli was assessed following the administration of IV paracetamol.
Strength of evidence
Weak.
Outcomes reported
The findings of the first two studies presented appear to directly contradict each other. The first study demonstrated a reduction in pain in all groups and found no differences in analgesia between IV paracetamol and other non-steroidal anti-inflammatories drugs (NSAIDs), while the second study reported no analgesia effects from IV paracetamol and was terminated prematurely because a high number of dogs required rescue analgesia. The first study reported sufficient analgesic effects of IV paracetamol and the second study reported no analgesia effects of IV paracetamol. Both were blinded, randomised, controlled studies and directly addressed the PICO question in relation to the peri / postoperative analgesic effects of IV paracetamol. However, their methods and sample sizes were very different. The third study did not demonstrate a clinically relevant sevoflurane MAC reduction after IV paracetamol in dogs.
Conclusion
At present, there is limited and weak evidence to suggest that IV paracetamol provides peri / postoperative analgesia in dogs. However, further studies are required to better assess its efficacy, its duration of action, and the appropriate doses that are necessary to reach therapeutic plasma levels. The reduced incidence of side effects at the currently recommended doses could support its peri / postoperative use, where NSAIDs use is contraindicated.

How to apply this evidence in practice
The application of evidence into practice should take into account multiple factors, not limited to: individual clinical expertise, patient’s circumstances and owners’ values, country, location or clinic where you work, the individual case in front of you, the availability of therapies and resources.
Knowledge Summaries are a resource to help reinforce or inform decision making. They do not override the responsibility or judgement of the practitioner to do what is best for the animal in their care.
Intervenciones urbanas de Regiones Devastada: zona de Levante = Urban interventions of Regiones Devastadas: Levante area
Authors: Portalés Mañanós Ana 
Published: April 2024

ResumenEl final de la Guerra Civil española supone el inicio de toda una serie de actuaciones encaminadas a recomponer el país, siendo una de las más importantes la reconstrucción de las ciudades que habían sido arrasadas por el conflicto bélico. En 1939 se crearon varios organismos de intervención estatal, entre ellos la Dirección General de Regiones Devastadas (DGRD). Este organismo contaba con una distribución administrativa descentralizada en oficinas comarcales que actuaban en los pueblos adoptados, agrupados geográficamente según zonas. El artículo es un extracto de una tesis que tiene por objetivo mostrar la obra promovida por la DGRD en la zona de Levante. Para ello, se expondrán los objetivos del organismo y las intervenciones desarrolladas en los pueblos adoptados en el conjunto del territorio español, así como las desarrolladas en Levante. Se ha recurrido a las fuentes originales de los proyectos a través de archivos públicos y privados, se han realizado visitas de campo a las distintas poblaciones, se ha contado con entrevistas de personajes próximos a los arquitectos participantes, y se ha hecho un vaciado de la revista Reconstrucción. AbstractThe end of the Spanish Civil War marks the beginning of a whole series of actions aimed at rebuilding the country, one of the most important being the reconstruction of the cities that had been devastated by the war. In 1939, several state intervention agencies were created, including the Dirección General de Regiones Devastadas (DGRD). This organization had a decentralized administrative distribution in regional offices that operated in the adopted towns, grouped geographically according to areas. The article is an excerpt from a thesis that aims to show the work promoted by the DGRD in the Levante area. To this end, the objectives of the organization and the interventions developed in the adopted towns throughout the Spanish territory, as well as those developed in the Levant, will be explained. The original sources of the projects have been used through public and private archives, field visits have been made to the different towns, there have been interviews with people close to the participating architects, and an emptying of the Reconstruction magazine.
Analisis Pengaruh Roa, Ekuitas dan Inflasi Terhadap Pendapatan dengan Pembiayaan Musyarakah sebagai Variabel Intervening pada Bank Mega Syariah di Masa Pandemi
Authors: Budianto Achyat , Ferawati Rofiqoh , Prayogo3 Youdhi 
Published: April 2024

Penelitian ini bertujuan untuk mengetahui pengaruh ROA, Ekuitas dan Inflasi terhadap pendapatan dengan pembiayaan Musyarakah sebagai variabel intervening pada Bank Mega Syariah di masa Pandemi. Sampel dalam penelitian ini bersumber dari laporan keuangan Bank Mega Syariah periode tahun 2020 sampai tahun 2022. Data dalam penelitian adalah data sekunder yang berjumlah 35 data. Pengujian hipotesis menggunakan analisis jalur dengan bantuan program Eviews. hasil penelitian menunjukkan variabel pembiayaan musyarakah mampu memediasi ekuitas berpengaruh terhadap pendapatan, Sedangkan ROA dan Inflasi tidak berpengaruh terhadap pendapatan melalui pembiayaan musyarakah
Vitamin D Deficiency Leads to Poorer Health Outcomes and Greater Length of Stay After Total Knee Arthroplasty and Supplementation Improves Outcomes
Authors: Vivek Kavyesh , Kamal Rayan , Perera Edward , Gupte Chinmay M. 
Published: April 2024

Background:
Vitamin D deficiency is increasingly identified as a predictor of poorer outcomes in musculoskeletal disease affecting as many as 1 in 4 people. This study aimed to evaluate the effect of vitamin D supplementation on outcomes after primary total knee arthroplasty (TKA).

Methods:
A targeted search of terms related to vitamin D and TKA outcomes was performed in PubMed, Cochrane Central Register of Controlled Trials, ClinicalTrials.gov, American Academy of Orthopaedic Surgeons, and British Orthopaedic Association databases. The results were analyzed using forest plots with I2 heterogeneity statistics and pooled effects with 95% confidence intervals (CIs) and p values. A p < 0.05 was considered statistically significant.

Results:
A total of 146,054 patients with 150,107 TKRs were analyzed in 10 studies that complied with the inclusion criteria, of which 3 were suitable for meta-analysis. Of these, 4 of the 10 studies showed that vitamin D deficiency resulted in poorer functional outcome scores (Western Ontario and McMasters Universities Osteoarthritis Index, Knee Society Scoring System, and American Knee Society scores), as well as increased risk of revision surgery, incidence of joint infection, and postoperative stiffness. Meta-analysis of length of hospital stay (LOS) demonstrated a significant increase in LOS in patients with vitamin D deficiency (standardized mean difference, −0.54, 95% CI, −0.69 to −0.38, p < 0.00001). Furthermore, outcomes were improved with vitamin D supplementation in 6 of 10 studies.

Conclusion:
Vitamin D deficiency results in poorer outcomes of primary TKA, with improved outcomes after supplementation. Further studies should examine the role of preoperative vitamin D screening and/or perioperative supplementation in primary TKA and standardize outcome measures to assess their effect.

Level of Evidence:

Level I/II. See Instructions for Authors for a complete description of levels of evidence.
WITHDRAWN: Numerical Study on the Performance Evaluation and Thermal Management of Automotive Exhaust Thermoelectric Generator using Pin fins
Authors: Veer Chander 
Published: April 2024

Abstract
The utilization of thermoelectric power generators presents a viable prospect for the recuperation of waste heat that results from exhaust gases within the automotive sector. The optimal performance of thermoelectric modules in waste heat recovery applications is heavily dependent on the design of the heat exchanger. The current study employs numerical methods to examine the efficacy of pin-fin configurations on the hot-side heat exchanger surface in enhancing heat transfer and thereby improving the conversion efficiency of TEG. Specifically, the study explores the impact of inline, staggered, and progressive arrangements of pin-fins in the direction of the exhaust stream. The heat exchanger is subjected to variations in fin thickness ranging from 10 mm to 18 mm to improve heat transfer in each configuration. The study conducts simulations on every fin configuration, utilizing three distinct inlet velocities (4 m/s, 6 m/s, and 8 m/s) and five different inlet temperatures (423 K, 473 K, 523 K, 573 K, and 623 K). The assessment of the heat exchanger’s performance is conducted by means of the thermalhydraulic performance coefficient (THPC) and the temperature uniformity index. Meanwhile, the evaluation of the TEG device’s performance is carried out by estimating its rated power output and the conversion efficiency of TEG. According to the findings, the staggered fin arrangement exhibits the highest Thermal Hydraulic Performance Coefficient (THPC) and power generation capability, while the progressive and inline fin configurations follow in descending order. The utilization of fins with a thickness of 18 mm in a staggered arrangement yields a peak rated power output of 53.42 W. The implementation of pin fins in a staggered configuration within the heat exchanger amplifies the heat transfer from the exhaust gas to the thermoelectric module. Consequently, there is an increase in the output power with respect to the given temperature difference.
Prenatal manifestation of Transient Abnormal Myelopoiesis in a genotypically normal fetus: case report and review of the literature
Authors: Walasik Izabela , Litwinska-Korcz Ewelina , Szpotańska Monika , Stanirowski Paweł , Księżopolska Aleksandra , Ludwin Artur , Litwinska Magdalena 
Published: April 2024

Abstract
Background: Congenital malignancies are unusual fetal conditions and therefore the data on their prenatal manifestation is limited. Transient abnormal myelopoiesis (TAM) is a hematologic disorder characteristic for babies with trisomy 21 and base on transient appearance of the blast cells in peripheral blood. This paper presents prenatal manifestation of congenital TAM in a genotypically normal newborn and reviews the literature on prenatal manifestation of this disorder.
Case presentation: A pregnant woman in her third pregnancy referred herself to the hospital for reduced fetal movements at 30 weeks of gestation. Admission’s ultrasound scan showed an increased middle cerebral artery peak systolic velocity (MCA PSV) together with hepatomegaly. The patient was admitted to the labor ward for cardiotocography monitoring which showed an acute fetal distress with repeated unprovoked decelerations. An emergency cesarean section was conducted and a phenotypically normal female newborn with low Apgar score was delivered. Further examination of peripheral blood revealed anemia and leukocytosis with high blast proportion. A bone marrow aspirate revealed 70.2% of blasts in a sample with an abnormal karyotype of 47,XX+21. Cytogenetic analysis of blasts with later microarray comparative genomic hybridizationconfirmed the presence of GATA1 mutation. However, the buccal smear showed a normal karyotype in the infant. The disease was classified as TAM. The literature review together with the case presentation showed that increased MCA PSV and hepatosplenomegaly are important risk factors of death in fetuses with TAM.
Conclusions: Our study demonstrates a rare case of prenatal manifestation of TAM in genotypically normal neonate. Obstetricians should pay attention to symptoms like high MCA PSV and hepatosplenomegaly as possible causes of fetal hematological disorders and differentiate it with infection or isoimmunization.
Prognostic role of plasma IL-17a expression and neoadjuvant therapy efficacy in breast cancer
Authors: Yu Liyan , Miao Huilai , Zeng Xiangning , Liu Guoqing , Xie Jiaxin , Liang Zhongzeng , Zhang Yuanqi 
Published: April 2024

Abstract
Background
Breast cancer (BC) is a common and highly malignant disease. Recently, IL-17a was found to be associated with several human malignancies. This study aims to investigate plasma IL-17a expression in BC and explore its role in disease progression and its interaction with neoadjuvant therapy efficacy.
Methods
Plasma IL-17a expression in BC tissue samples from 54 patients who received neoadjuvant therapy were analyzed and assessed using immunohistochemistry.
Results
Statistical analysis showed that a high expression of IL-17a before and after neoadjuvant therapy was positively correlated to poor responses (stable disease and progressive disease) (SD + PD). Conversely, IL-17a was significantly decreased in patients with good responses (complete response and pathologic partial response) (CR + PR) compared with patients with poor responses. Moreover, IL-17a was more easily decreased in patients with earlier stages. Furthermore, plasma IL-17a was positively correlated with poor prognosis (PFS) after treatment.
Conclusions
IL-17a is a potential biomarker of neoadjuvant therapy for BC.
Etiological Exploration of Enamel Defects: A cross-sectional study to Unravel Maternal, Prenatal, and Early Childhood Influences
Authors: Jeghami Rania Al , Al-Nerabieah Zuhair , Dashash Mayssoon 
Published: April 2024

Abstract
Background
Enamel developmental defects (EDs) significantly impact pediatric dental health. This cross-sectional study in Damascus explores the prevalence and etiological factors of EDs in Syrian children (ages 7 to 12).
Methods
Adopting a cross-sectional observational design, the study adhered to STROBE guidelines. A total of 2000 participants underwent clinical examination using the Enamel Defect Index (EDI). Phone interviews with families aimed to uncover etiological factors.
Results
Prevalence of EDs was 16.1%, with Localized Enamel Defects (LEDS) and Molar-Incisor Hypomineralization (MIH) being most common. Regional variations, parental education, and consanguineous marriage correlated with ED occurrence. MIH prevailed in higher economic strata.
Conclusion
This study sheds light on the prevalence and factors influencing EDs in Syrian children. While not establishing direct links with maternal health conditions, it underscores the intricate interplay of genetic and environmental factors. Further investigations are crucial for a nuanced understanding, informing preventive and intervention strategies in pediatric dental health.
Identification of a new HIV-1 circulating recombinant form (CRF159_01103) derived from CRF103_01B and CRF01_AE in Hebei Province, China
Authors: Fan Weiguang , Zhang Zhen , Shi Haoxi , Jia Jianru , Shi Penghui , Chen Sisi , Lu Xinli 
Published: April 2024

Abstract

Recombinant HIV-1 genomes identified in three or more epidemiological unrelated individuals are defined as circulating recombinant forms (CRFs). CRFs can further recombine with other pure subtypes or recombinants to produce secondary recombinants. In this study, a new HIV-1 intersubtype CRF, designated CRF159_01103, isolated from three men who have sex with men (MSM) with no epidemiological linkage, was identified in Baoding city, Hebei Province, China. CRF159_01103 was derived from CRF103_01B and CRF01_AE. Bayesian molecular clock analysis was performed on the CRF01-AE and CRF103_01B regions of CRF159_01103. The time of origin of CRF159_01103 was predicted to be 2018–2019, indicating that it is a recent recombinant virus. The emergence of CRF159_01103 has increased the complexity of the HIV-1 epidemic in Hebei Province.