bluuebunny/crossref_metadata_2025_split huggingface dataset:
Entropy Stabilized Medium High Entropy Alloy Anodes for Lithium‐Ion Batteries
Authors: Alvi Sajid , Black Ashley P. , Jozami Ignacio , Escudero Carlos , Akhtar Farid , Johansson Patrik 
Published: March 2024

AbstractOne often proposed route to improved energy density for lithium‐ion batteries is to use alloy anodes, such as silicon, able to store large amounts of lithium. Mechanical instability caused by the large expansion and contraction associated with (de)lithiation, and hence bad cyclability, has, however, so far hindered progress. As proof‐of‐concept of a remedy, we here present BiSbSe1.5Te1.5, a medium high‐entropy alloy with improved cycling stability for conversion‐alloying (de)lithiation reactions. We attain five to twenty times more stable cycles than previously reported for comparable metal‐Se and ‐Te‐based anodes, with a very good reversible capacity (464 mAh g−1) for up to 110 cycles‐ and this without using any carbonaceous materials to create a composite. Altogether, this highlights how alloy engineering and increased entropy materials can stabilize conversion‐alloying electrodes.
Limb–body wall complex: Literature review and case report
Authors: Cortés‐Enríquez Omar Daniel , Tapia‐Fonseca Claudia Vanessa , Torres‐Fuentes María Angelina , Torres‐Riojas Paola Berenice , Raya‐Garza Laura Patricia 
Published: March 2024

AbstractIntroductionBody wall anomalies comprise a wide range of malformations. Limb–Body wall complex (LBWC) represents the most severe presentation of this group, with life threatening malformations in practically all the cases, including craniofacial, body wall defects, and limb anomalies. There is no consensus about its etiology and folding and gastrulation defects have been involved. Also, impaired angiogenesis has been proposed as a causative process.Case ReportWe present the case of a masculine stillborn, product of the first pregnancy in a 15‐year‐old, apparently healthy mother. He was delivered at 31 weeks of gestation due to an early rupture of membranes. He presented with multiple malformations including a wide body wall defect with multiple organ herniation and meromelia of the lower right limb.Discussion and ConclusionsLBWC represents a severe and invariably fatal pathology. There are no described risk factors, nevertheless, this case presented in a teenage mother, a well‐described risk factor for other body wall anomalies. Its diagnosis allows us to discriminate between other pathologies that require prenatal or postnatal specialized treatment.
The role of ncRNAs‐mediated pyroptosis in diabetes and its vascular complications
Authors: Feng Xinyao , Yang Xiaoxu , Zhong Yancheng , Cheng Xihua 
Published: March 2024

AbstractOver the past decade, the prevalence of diabetes has increased significantly worldwide, leading to an increase in vascular complications of diabetes (VCD), such as diabetic cardiomyopathy (DCM), diabetic nephropathy (DN), and diabetic retinopathy (DR). Noncoding RNAs (ncRNAs), such as microRNAs (miRNAs), long Noncoding RNAs (lncRNAs), and circular RNAs (circRNAs), play a key role in cellular processes, including the pathophysiology of diabetes and VCD via pyroptosis. ncRNAs (e.g., miR‐17, lnc‐MEG3, and lnc‐KCNQ1OT1) can regulate pyroptosis in pancreatic β cells. Some ncRNAs are involved in VCD progression. For example, miR‐21, lnc‐KCNQ1OT1, lnc‐GAS5, and lnc‐MALAT1 were reported in DN and DCM, and lnc‐MIAT was identified in DCM and DR. Herein, this review aimed to summarize recent research findings related to ncRNAs‐mediated pyroptosis at the onset and progression of diabetes and VCD.
A Dual‐Gene Reporter‐Amplifier Architecture for Enhancing the Sensitivity of Molecular MRI by Water Exchange
Authors: Huang Yimeng , Chen Xinyue , Zhu Ziyue , Mukherjee Arnab 
Published: March 2024

AbstractThe development of genetic reporters for magnetic resonance imaging (MRI) is essential for investigating biological functions in vivo. However, current MRI reporters have low sensitivity, making it challenging to create significant contrast against the tissue background, especially when only a small fraction of cells express the reporter. To overcome this limitation, we developed an approach for amplifying the sensitivity of molecular MRI by combining a chemogenetic contrast mechanism with a biophysical approach to increase water diffusion through the co‐expression of a dual‐gene construct comprising an organic anion transporting polypeptide, Oatp1b3, and a water channel, Aqp1. We first show that the expression of Aqp1 amplifies MRI contrast in cultured cells engineered to express Oatp1b3. We demonstrate that the contrast amplification is caused by Aqp1‐driven increase in water exchange, which provides the gadolinium ions internalized by Oatp1b3‐expressing cells with access to a larger water pool compared with exchange‐limited conditions. We further show that our methodology allows cells to be detected using approximately 10‐fold lower concentrations of gadolinium than that in the Aqp1‐free scenario. Finally, we show that our approach enables the imaging of mixed‐cell cultures containing a low fraction of Oatp1b3‐labeled cells that are undetectable on the basis of Oatp1b3 expression alone.
Posterior reversible encephalopathy syndrome associated with dengue fever induced intrauterine death: A case report
Authors: Biswas Himel Kumar , Ibu Khadija Tanbil Ishaque , Biswas Rama , Ahmed Md Nasir Uddin 
Published: March 2024

Key Clinical MessageIn recent years dengue fever has become a major health concern specifically due to its diverse presentation and adverse outcome. Progression from mild febrile illness to a severe systemic illness may occur in dengue fever including neurological disorder. Here, we report an unusual and rare case of a 20‐year‐old mother who developed posterior reversible encephalopathy syndrome (PRES) following dengue fever induced intrauterine death and septic shock.
Ulcerative sarcoidosis: An atypical cause of leg ulcers
Authors: Miyaue Kazuki , Hoshi Tetsuya , Isono Hiroki 
Published: March 2024

Key Clinical MessageWe present the case of an 83‐year‐old woman with leg ulcers who was diagnosed with sarcoidosis. This case highlights the importance for clinicians to consider ulcerative sarcoidosis when encountering patients with leg ulcers along with hilar adenopathy, uveitis, elevated serum angiotensin‐converting enzyme, and histopathological findings of epithelioid cell granulomas.
An application of psychology of working theory to chronic health issues: Importance of decent work
Authors: Raque Trisha L. , Wright Orphea D. , Duffy Ryan D. 
Published: March 2024

AbstractThis paper presents psychology of working theory (PWT) as a framework for addressing career concerns faced by those with chronic health issues. PWT is a relevant framework for contextualizing the lived experiences of clients navigating work and chronic illness. Specifically, individuals with chronic health conditions may face additional barriers to their career development and are at risk for higher incidences of workplace discrimination, job stress, and job loss. Core elements of PWT outlined in this paper are applied to a case study of a client with breast cancer. More specifically, the constructs of decent work, critical consciousness, and career adaptability are applied at the level of the individual and systemic interventions. Issues of equity, access, intersectionality, power, and privilege are highlighted as they relate to the context of work. We offer suggestions for advocacy for career counselors working with clients with chronic illness navigating work and careers.
PROTOCOL: Effectiveness of public‐private partnerships on educational access and quality of primary and secondary schooling in low‐ and middle‐income countries: A systematic review
Authors: Ali Sajid , Bhutta Sadia Muzaffar , Ahmad Sohail , Ansari Aisha Naz , Ahmed Afaq , Qadir Yasir 
Published: March 2024

AbstractThis protocol serves as a guiding source for a Campbell registered systematic review aiming to assess the effectiveness of Public‐Private Partnerships (PPPs) in education in Low‐ and Middle‐Income Countries (LMICs). The primary question for this review is: What is known about the impact of PPPs on improving access (i.e., enrolment, attendance, drop‐out, and completion) and quality (i.e., students’ learning outcomes and teachers’ teaching practices) of primary and secondary schooling in LMICs? Using a predefined search query, we will retrieve studies from various databases including Scopus, Campbell Library, EBSCO Education Research Complete, NBER, Dissertation and Theses Global (ProQuest), along with other sources of grey literature. Covidence will be used for screening and extraction. A bias assessment tool will be used for the included studies. A standardised mean difference (SMD) effect size of Hedges’ g will be calculated for the outcome variables using RevMan.This review will provide updated evidence about the impact of PPP in school education across LMICs, which will be instrumental for policy and practice level decisions for education improvement.
Pathologic classification of a late‐onset peripheral neuropathy in a spontaneous Labrador retriever dog model
Authors: Anderson Ryan S. , Chu Alexander K. , Rylander Helena , Binversie Emily E. , Duncan Ian D. , Baker Lauren , Salamat Shahriar , Patterson Margaret M. , Gruel Jordan , Kohler Nyah L. , Kearney Hannah K. , Ale Shelby M. , Momen Mehdi M. , Muir Peter , Svaren John P. , Johnson Rebecca , Sample Susannah J. 
Published: March 2024

AbstractLate‐onset peripheral neuropathy (LPN) is a heritable canine neuropathy commonly found in Labrador retrievers and is characterized by laryngeal paralysis and pelvic limb paresis. Our objective was to establish canine LPN as a model for human hereditary peripheral neuropathy by classifying it as either an axonopathy or myelinopathy and evaluating length‐dependent degeneration. We conducted a motor nerve conduction study of the sciatic and ulnar nerves, electromyography (EMG) of appendicular and epaxial musculature, and histologic analysis of sciatic and recurrent laryngeal nerves in LPN‐affected and control dogs. LPN‐affected dogs exhibited significant decreases in compound muscle action potential (CMAP) amplitude, CMAP area, and pelvic limb latencies. However, no differences were found in motor nerve conduction velocity, residual latencies, or CMAP duration. Distal limb musculature showed greater EMG changes in LPN‐affected dogs. Histologically, LPN‐affected dogs exhibited a reduction in the number of large‐diameter axons, especially in distal nerve regions. In conclusion, LPN in Labrador retrievers is a common, spontaneous, length‐dependent peripheral axonopathy that is a novel animal model of age‐related peripheral neuropathy that could be used for fundamental research and clinical trials.
Bigger is not Better for Indolino‐Oxazoline Photochemical Properties
Authors: Ayoub Augustin , Le Bras Laura , Leriche Philippe , Champagne Benoît , Sanguinet Lionel 
Published: March 2024

AbstractIndolino‐oxazolidine derivatives are a new and pretty confidential family of multimodal molecular switches. Indeed, acid, electrochemical potential, and UV light irradiation can be used to convert these compounds form their colorless closed form to a colorful open form. In this publication, we have investigated the influence of the extension of the π‐conjugated system beared by the indolino moiety on their halo‐, electro‐ and photochromic properties. In this context, we have demonstrated that only their photochemical properties are strongly affected by this structural modification. Moreover, quantum chemistry calculations have allowed to rationalize our experimental observations and, noticeably, evidenced an oxidative quenching process in presence of chlorobenzene, which enhances their photoreactivity.
Cocrystallization for Improving Anticancer Activity of Drugs
Authors: Alvani Amin , Shayanfar Ali 
Published: March 2024

AbstractCocrystallization can change the physicochemical and pharmacokinetic properties of active pharmaceutical ingredients (API) and improve biological activities. This study focuses on the documented biological activities of APIs in cocrystal form, specifically those with anticancer properties. Additionally, the mechanisms by which these APIs exhibit modified anticancer effects are discussed. Generally, this technique can change anticancer activity through solubilization, enhancing dissolution rate, permeability improvement, stabilization, producing a slow‐release form, and retaining transient in solution and interaction with receptors.
Geochemical and microbiological variability of aerobic and anaerobic sediments along a bifurcated sulphate‐saturated brine spring in western Canada
Authors: Broughton Paul L. 
Published: March 2024

AbstractA tufa mound developed at La Saline Lake, an oxbow of the Athabasca River in the Athabasca Oil Sands deposit of north‐east Alberta, is characterised by an unusual emplacement of a gypsum caprock. This two‐tiered architecture resulted from the bicarbonate‐saturated groundwater flow along Upper Devonian limestone being redirected deeper and encountering the halite–anhydrite dissolution trend within the underlying Middle Devonian Prairie Evaporite Formation, 175 to 200 m below. Migrations up‐section of sulphate‐saturated brine resulted in the gypsum caprock on the tufa mound and discharge of a sulphate‐saturated brine spring with total dissolved solids of ca 80,000 mg/L. The brine spring is bifurcated with flows to the south‐west and north‐west. Calcite–gypsum thrombolytic bottom sediments along the south‐western branch were covered by a halite deposit and subsequently a gypsum crust with a microbial community dominated by the cyanobacteria Coleofasciculus chthonoplastes. The thrombolite contact zone with the halite–gypsum encrustation has a more diversified community with the cyanobacteria Dactylococcopsis. Cyanobacterial mats that wrap around the bulbous gypsum crust protuberances distributed along the brine pool bottom surfaces have significant eukaryotic diversity, represented by the heterotrophic Ochrophyte Paraphysomonas. In contrast, sediments accumulated along the adjacent spring branch flow to the north‐west were thicker and clogged by abundant decomposed and fermented floral debris, unlike the deposit accumulated along the south‐western branch. This resulted in an oxygen‐depleted anaerobic environment dominated by sulphate‐reducing bacteria resulting in a calcite‐rich and sulphate‐starved anaerobic sediment with ca 20% elemental sulphur and emanation of H2S gas.
Three cases of collared owlet depredation on the green‐backed tit within nest boxes
Authors: Bibi Nehafta , Yuan Qingmiao , Chen Caiping , Chen Shaolian , Duan Yubao , Luo Xu 
Published: March 2024

AbstractThe main cause of the reproductive failure of cavity‐nesting birds is nest predation, even though cavity nests protect from numerous predators. To study the breeding biology of the green‐backed tit (Parus monticolus) and to promote the reproduction of some other avian cavity breeders, we placed 245 nest boxes in the Zixi Mountain, southwest China. We collected breeding data by regularly checking the artificial nest boxes, three cases of green‐backed tits being predated by collared owlet (Glaucidium brodiei) were confirmed by the video recordings. Larger mammals, chipmunks, squirrels, sparrowhawks, jays, and snakes have been identified as common predators of cavity‐nesting birds in high‐latitude regions of the northern hemisphere. Limited research in tropical and subtropical regions, particularly in Asia, has demonstrated squirrels and snakes as common predators of cavity‐nesting birds. A gap in avian predators to cavity‐nesting birds exists in the current knowledge. Hence the three cases of collared owlet's depredation reveal a new danger to green‐backed tits, broadening our knowledge of the dynamics of cavity‐nesting birds. In all three cases, the artificial box's entrance hole was only 5 × 5 cm in size and has not been expanded or poked. These findings provided evidence that the collared owlet is the predator of nestlings and adult green‐backed tit breeding in artificial boxes, which emphasized a reevaluation of predator–prey interactions. Therefore, for effective breeding of the green‐backed tit, we suggest to choose a hole size of 3 × 3 cm that is appropriate for its body size.
Food resource richness increases seed disperser visitations and seed rain richness
Authors: Holdgrafer James P. , Mason David S. , Coleman Tyler Steven , Lashley Marcus A. 
Published: March 2024

AbstractWithin the context of global change, seed dispersal research often focuses on changes in disperser communities (i.e., seed dispersers, such as birds, in an area) resulting from habitat fragmentation. This approach may not be completely illustrative due to certain seed disperser communities being more robust to fragmentation. Additionally, this top‐down approach overlooks how changing food resources on landscapes impacts resource tracking and, subsequently, seed dispersal. We hypothesized resource tracking may promote diffuse plant–animal dispersal mutualisms if resource richness is positively linked to disperser and seed rain richness. We predicted increasing food resource richness attracts more visits and species of avian dispersers, resulting in higher counts and greater species richness of seeds deposited at sites (i.e., seed rain). We tested this mechanism in two replicated field experiments using a model system with bird feeders positioned above seed traps. In the first experiment, we demonstrated resource presence skews seed rain. In the second experiment, we explored how species richness of food resources (0, 4, 8, or 12 species) affected the species richness and visitation of avian seed dispersers at feeders and in subsequent seed rain. Collectively, we observed a positive relationship between available food resources and seed rain, likely mediated by resource tracking behavior of avian dispersers. Our findings underscore a potential key mechanism that may facilitate ecological diversity, whereby accumulating species richness in the plant community attracts a more diverse seed disperser community and indirectly promotes more species in seed rain. Importantly, the resource tracking mechanism driving this potential positive feedback loop may also result in negative ecosystem effects if global change diminishes resource availability through homogenization processes, such as invasive species colonization. Future research should explore the bottom‐up effects of global change on food resources and seed disperser behavior to complement the literature on changing disperser communities.
Validating hidden Markov models for seabird behavioural inference
Authors: Akeresola Rebecca A. , Butler Adam , Jones Esther L. , King Ruth , Elvira Víctor , Black Julie , Robertson Gail 
Published: March 2024

AbstractUnderstanding animal movement and behaviour can aid spatial planning and inform conservation management. However, it is difficult to directly observe behaviours in remote and hostile terrain such as the marine environment. Different underlying states can be identified from telemetry data using hidden Markov models (HMMs). The inferred states are subsequently associated with different behaviours, using ecological knowledge of the species. However, the inferred behaviours are not typically validated due to difficulty obtaining ‘ground truth’ behavioural information. We investigate the accuracy of inferred behaviours by considering a unique data set provided by Joint Nature Conservation Committee. The data consist of simultaneous proxy movement tracks of the boat (defined as visual tracks as birds are followed by eye) and seabird behaviour obtained by observers on the boat. We demonstrate that visual tracking data is suitable for our study. Accuracy of HMMs ranging from 71% to 87% during chick‐rearing and 54% to 70% during incubation was generally insensitive to model choice, even when AIC values varied substantially across different models. Finally, we show that for foraging, a state of primary interest for conservation purposes, identified missed foraging bouts lasted for only a few seconds. We conclude that HMMs fitted to tracking data have the potential to accurately identify important conservation‐relevant behaviours, demonstrated by a comparison in which visual tracking data provide a ‘gold standard’ of manually classified behaviours to validate against. Confidence in using HMMs for behavioural inference should increase as a result of these findings, but future work is needed to assess the generalisability of the results, and we recommend that, wherever feasible, validation data be collected alongside GPS tracking data to validate model performance. This work has important implications for animal conservation, where the size and location of protected areas are often informed by behaviours identified using HMMs fitted to movement data.
Effect of long‐term tafamidis treatment on health‐related quality of life in patients with transthyretin amyloid cardiomyopathy
Authors: Grogan Martha , Davis Margot K. , Crespo‐Leiro Maria G. , Sultan Marla B. , Gundapaneni Balarama , Stedile Angeli Franca , Hanna Mazen 
Published: March 2024

AbstractAimsTo evaluate the effect of long‐term tafamidis treatment on health‐related quality of life (HRQoL) in patients with transthyretin amyloid cardiomyopathy (ATTR‐CM) enrolled in the Tafamidis in Transthyretin Cardiomyopathy Clinical Trial (ATTR‐ACT) and long‐term extension (LTE) study.Methods and resultsWe examined change from baseline in Kansas City Cardiomyopathy Questionnaire overall summary (KCCQ‐OS) and clinical summary (KCCQ‐CS) scores in patients who received tafamidis meglumine 80 mg for 30 months in ATTR‐ACT and tafamidis (meglumine 80 mg or bioequivalent free acid 61 mg) for 30 months in the LTE study, and in patients who received placebo for 30 months in ATTR‐ACT and tafamidis for 30 months in the LTE study. In ATTR‐ACT, 176 and 177 patients were randomized to tafamidis 80 mg and placebo, respectively. Patients who continuously received tafamidis had a 6‐ to 7‐point reduction in least squares (LS) mean (standard error) KCCQ‐OS and KCCQ‐CS scores at month 30 (−6.25 [1.53] and −7.48 [1.39]), with little or no further decline over the next 30 months (−5.92 [1.77] and −9.21 [1.88] at month 60). Patients who received placebo in ATTR‐ACT had a 20‐point reduction in LS mean KCCQ‐OS and KCCQ‐CS scores at month 30 (−19.60 [1.94] and −19.90 [2.01]), but the decline slowed after initiating tafamidis (−24.70 [3.04] and −25.30 [3.36] at month 60).ConclusionTafamidis reduced HRQoL decline in patients with ATTR‐CM. Patients continuously treated with tafamidis for 60 months demonstrated stabilized HRQoL. In patients who initially received placebo in ATTR‐ACT, tafamidis reduced the decline in HRQoL during the LTE study.