bluuebunny/crossref_metadata_2025_split huggingface dataset:
Temporary disability pension recipients: Contextual stress factors
and their effect on return-to-work-intention
Authors: Savvoulidou Dimitra , Kröger Christoph , Kobelt-Pönicke Axel 
Published: April 2024

Abstract
Background and purpose In the last decades, Germany has experienced a vast
increase in the number of individuals applying for or receiving disability
benefit. Only a small proportion of them intends to return to work. The present
study aims to identify and describe the percentage of temporary disability
pensioners, who have the intention to return to working life.
Methods The final sample consisted of 496 insured individuals who were
receiving temporary disability pension from the Regional German Pension
Insurance (DRV) at that time. Participation was voluntary and anonymous. The
following self-report instruments were administered: a. Evaluation of Contextual
Factors; b. German Symptom Validation Test (BEVA); c. German Patient Health
Questionnaire (PHQ-9); d. Readiness for Return-to-Work German Scale (RRTW).
Results The results revealed that approximately 6% of participants were at
the stage of “preparation”, 31.9% at the stage of “contemplation”, and more than
half of the participants were at the stage of “pre-contemplation” according to
the RRTW. Comparing the groups of “pre-contemplation” (Group 1) and
“contemplation+preparation” (Group 2+3), no statistically significant
differences were found, except for age.
Conclusions In conclusion, further research is required to identify
possible factors which could predict the stage of RRTW. New interventions are
needed that can raise the motivation for and success in the return to work of
disability pensioners.
Ultraschalluntersuchungen in der Kinderrheumatologie
Authors: Roth Johannes , Windschall Daniel 
Published: April 2024

ZUSAMMENFASSUNGDas kindliche Handgelenk und die Fingergelenke zeigen eine hohe anatomische Komplexität mit der Möglichkeit einer Pathologie im Bereich zahlreicher synovialer Rezessus, aber auch der verschiedenen Sehnenscheiden, des Paratenons und vieler verschiedener Enthesen, insbesondere im Bereich der Finger. Die Sicherheit und Genauigkeit bei der Diagnosestellung einer rheumatischen Entzündung profitiert deshalb wesentlich vom Ultraschall in Ergänzung zum klinischen Befund. Mehrere Studien der letzten Jahre konnten für diese Region die Überlegenheit des Ultraschalls versus klinischer Untersuchung nachweisen. Mit zunehmendem Einsatz des Gelenkultraschalls verbessern sich die diagnostischen Möglichkeiten bei der Diagnosestellung, Abgrenzung und im Verlaufsmonitoring kindlich rheumatischer Erkrankungen. Wichtige Differenzialdiagnosen können sonografisch ausgeschlossen oder bestätigt werden. Zunehmende Standards helfen bei der praktischen Durchführung, Beurteilung und Quantifizierung des pathologischen Befundes.
Enterovirus Infection in Preterm Quadruplets with Clinical
Presentation of Neonatal Late-Onset Sepsis: a Case Report
Authors: Seifert Viktor , Böck Lena , Wirbelauer Johannes 
Published: April 2024

AbstractThis is the unusual case of concurrent late-onset sepsis caused by enteroviruses
in preterm quadruplets in a neonatal ward. While viral infections are an
important differential diagnosis of bacterial sepsis in the outpatient setting,
the occurrence in a neonatal ward with strict prophylactic hygiene measures is
unusual. In this case, transmission of enteroviruses via breast milk appears
possible.
Auswirkungsanalyse einer neuen, sektorenübergreifenden Erbringung bisher stationärer endoskopischer gastroenterologischer Leistungen entsprechend §115f SGB
V (Hybrid-DRG): Zuordnungsmatrix und Kostenanalyse
Authors: Rathmayer Markus , Belle Sebastian , Heinlein Wolfgang , Dollhopf Markus , Braun Martin , Albert Jörg G. 
Published: April 2024

Zusammenfassung
Hintergrund Mit Einführung des §115f SGB V ist die Voraussetzung für eine „spezielle sektorengleiche Vergütung“ (‚Hybrid-DRG‘) geschaffen. In einer Auswirkungsanalyse haben wir bisher stationäre Gastroenterologisch-endoskopische (GAEN)-Fälle in einer Matrix der zukünftigen Hybrid-DRG vs. dem ambulanten Operieren (AOP) oder einer stationären Behandlung zugeordnet.
Methoden In ausgewählten DRGs (G47B, G67A, G67B, G67C, G71Z, H41D, H41E) wurde eine Zuordnungsmatrix von GAEN-Fällen medizinisch begründet erstellt. Leistungsgruppen des DGVS-Leistungskatalogs wurden hierfür durch eine Expertengruppe anhand des Positionspapiers der DGVS den Gruppen Hybrid-DRG, AOP und Stationär zugeordnet. Kostendaten aus dem DGVS-DRG-Projekt des Datenjahres 2022 aus 36 InEK-Kalkulationskrankenhäusern mit insgesamt 232.476 GAEN-Fällen wurden ausgewertet.
Ergebnisse 26 Leistungsgruppen des DGVS-Leistungskatalogs wurden der Gruppe „Hybrid-DRG“, 24 der Gruppe „stationär“, 12 der Gruppe „AOP“ zugeordnet. 7 Leistungsgruppen wurden „abhängig vom OPS-Kode“ gesplittet und auf dieser Ebene eingestuft. Fälle mit Zusatzentgelten wurden von einer Hybrid-DRG ausgeschlossen, da diese dort nicht vereinbart werden können.Die Kostenanalyse zeigt, dass Leistungen, die bereits im AOP sind, ein ähnliches Kostenniveau haben, wie Leistungen, die als „Hybrid-DRG“ eingestuft wurden. Mit der Kostenkalkulation konnte für die gebildeten Hybrid-DRG ein Kostenniveau dargestellt werden.
Schlussfolgerung Auf Basis von klar definierten strukturellen, prozeduralen und personellen Voraussetzungen können Leistungen aus geeigneten DRGs in eine Hybrid-DRG überführt werden. Eine Zuordnung von Leistungen ohne die Einbeziehung von Fachexperten erscheint dabei äußerst schwierig. Die Fallzuordnung anhand willkürlicher Kontextfaktoren erhöht die Komplexität, ohne die Qualität der Zuordnung nachweislich zu erhöhen und müssen weiterentwickelt werden. Eine Kostenanalyse kann aus den bekannten stationären Kosten abgeleitet werden und muss als Grundlage für den Hybrid-DRG-Katalog 2025 dienen.
Clinical Pathways and Outcomes of Andexanet Alfa Administration for the Reversal of Critical Bleeding in Patients on Oral Direct Factor Xa Inhibitors
Authors: Goldin Mark , Smith Kolton , Koulas Ioannis , Leung Tungming , Ravi Mayuri , Parhar Sanjit , Shah Sejal , Floyd Kayla , Ohanesian Lori , Bain Rachel , Defonte Daniella , Ochani Kanta , Lin Amanda , Patel Bhumi , Tsaftaridis Nikolaos , Jnani Jack , Spyropoulos Alex C. 
Published: April 2024

Abstract
Background Andexanet is U.S. Food and Drug Administration (FDA) approved for the reversal of critical bleeding from factor Xa inhibitors and off-label for surgical reversal. Data are lacking on andexanet administration processes.
Methods We retrospectively studied patients at a 23-hospital system who received andexanet from November 2019 to March 2023. Abstractors coded demographics, comorbidities, anticoagulant use, andexanet indication, and process times. The primary outcome was presentation-to-andexanet time; diagnosis, ordering, and administration times were calculated. Secondary outcomes included in-hospital postandexanet major thromboembolism/bleeding and mortality.
Results In total, 141 patients were analyzed. Andexanet indications were predominantly neurologic bleeding (85.8%). Twenty-four patients (17.0%) were transferred from nontertiary/academic centers to tertiary/academic centers. The median presentation-to-administration time was 192.5 minutes (interquartile range [IQR]: 108.0–337.0 minutes). Components were as follows: 72.5 minutes (IQR: 39.0–137.5 minutes) for bleeding diagnosis; 35.5 minutes (IQR: 0–96.5 minutes) for andexanet ordering; and 53.0 minutes (IQR: 38.5–78.5 minutes) for administration, which was longer at tertiary/academic hospitals (ratio 1.5, 95% confidence interval [CI]: 1.2–2.0, p = 0.002). Gastrointestinal or other critical bleeding (ratio 2.59, 95% CI: 1.67–4.02, p < 0.001), and tertiary/academic center treatment (ratio 1.58, 95% CI: 1.15–2.18, p = 0.005), were associated with increased time. Major thromboembolism, bleeding, and mortality occurred in 10.6, 12.0, and 22.9% of patients, respectively.
Conclusions In our cohort, the median presentation-to-administration time was over 3 hours. Cumulative times were longer at tertiary/academic hospitals and for gastrointestinal/other bleeding. Postandexanet major thromboembolism/bleeding occurred more at tertiary/academic hospitals, possibly related to transfers. Prospective studies may elucidate clinical decision-making bottlenecks.
Efficient Synthesis of N-(Difluoropropenyl)amides/Amines from Fluorinated Olefins under Base Promotion
Authors: Li Yang , Li Xin-Yue , Shi Yi-Ran , Li Zhi-Bo , Li Hong , Zhu Wen-Qing , Fan Qiang-Wei 
Published: April 2024

Abstract
N-(Difluoropropenyl)amides/amines are an important class of fluorinated compounds. Here, we report an efficient method for synthesizing these compounds without the use of transition metals. Under simple base-promoted conditions, 3-bromo-3,3-difluoroprop-1-ene reacts with N-methylanilines or N-arylacrylamides, with the elimination of one molecule of HBr, to give the target compound. Another efficient method for synthesizing difluoroalkenes is the reaction of 2-bromo-3,3,3-trifluoroprop-1-ene with indole or its analogues.
The Clinical Translation of α-humulene – A Scoping Review
Authors: Dalavaye Nishaanth , Nicholas Martha , Pillai Manaswini , Erridge Simon , Sodergren Mikael H. 
Published: April 2024

Abstractα-humulene, a sesquiterpene found in essential oils of various plant species, has garnered interest due to its potential therapeutic applications. This scoping review aims to consolidate α-humuleneʼs evidence base, informing clinical translation, and guiding future research directions. A scoping review was conducted of EMBASE, MEDLINE, and PubMed databases up to 14th July 2023. All studies describing original research on α-humulene extraction, as well as pre-clinical and clinical research, were included for review. Three hundred and forty articles were analysed. α-humulene yields ranged from negligible to 60.90% across plant species. In vitro experiments demonstrated cytotoxicity against adenocarcinomas (such as colorectal, pulmonary, breast, prostatic, lung, and ovarian), with varying responses in other cell models. Mechanistic insights revealed its involvement in mitochondrial dysfunction, diminished intracellular glutathione levels, and the induction of oxidative stress. In rodent studies, oral administration of α-humulene at 50 mg/kg reduced inflammation markers in paw oedema and ovalbumin-induced airway inflammation. Intraperitoneal administration of α-humulene (50 – 200 mg/kg) exhibited cannabimimetic properties through cannabinoid 1 and adenosine A2a receptors. α-humulene also exhibited a multitude of properties with potential scope for therapeutic utilisation. However, there is a paucity of studies that have successfully translated this research into clinical populations with the associated disease. Potential barriers to clinical translation were identified, including yield variability, limited isolation studies, and challenges associated with terpene bioavailability. Consequently, rigorous pharmacokinetic studies and further mechanistic investigations are warranted to effectively uncover the potential of α-humulene.
Transition-Metal-Catalyzed Direct Arylation of Ammonia
Authors: Song Geyang , Dong Jianyang , Xue Dong , Song Jiameng , Li Gang 
Published: April 2024

AbstractIn the past few decades, transition-metal-catalyzed direct amination of aryl halides with ammonia has attracted significant attention from chemists because of its broad substrate scope, good functional group compatibility, and high reaction selectivity. Herein, recent examples of transition-metal-catalyzed syntheses of aniline derivatives starting from aryl halides are reviewed.1	Introduction2	Heat-Driven Transition-Metal-Catalyzed Amination of Aryl Electrophiles2.1	Palladium-Catalyzed Amination2.2	Copper-Catalyzed Amination2.3	Nickel-Catalyzed Amination3	Light-Driven Transition-Metal-Catalyzed Amination of Aryl Electrophiles4	Conclusion and Outlook
A Comparison of Perioperative Complications and Outcomes in Patients Undergoing Cerebral Aneurysm Clipping Performed Ultra-Early (≤ 24 hours) versus Late (> 24 hours): A 7-Year Retrospective Study of 302 Patients
Authors: Muangman Saipin , Raksakietisak Manee , Vacharaksa Kamheang , Manomatangkul Kattiya , Chankaew Ekawut , Kotchasit Chayasorn , Deepinta Penpuk , Phoowanakulchai Sirima 
Published: April 2024

Abstract
Objectives The intracerebral aneurysm with subarachnoid hemorrhage (SAH) has a high morbidity and mortality rate. This study aimed to compare the incidences of perioperative complications in ultra-early surgery (within 24 hours) with those in late surgery (> 24 hours).
Methods Retrospective data were reviewed for 302 patients who underwent craniotomies with aneurysm clipping between January 2014 and December 2020. Perioperative data were obtained from the medical records and reviewed by the investigators. The complications were compared between ultra-early and late operations. We were interested in major complications such as delayed ischemic neurologic deficit (DIND), intraoperative aneurysm rupture (IAR), and anesthesia-related complications. The short-term (in hospital) and long-term (1 year) outcomes in patients with or without DIND and IAR were compared. The collected data was statistically analyzed.
Results Three hundred and two patients were analyzed, and 264 patients had completed follow-up. The ultra-early cases (150 patients) had a higher American Society of Anesthesiologists physical status, a lower Glasgow Coma Scale, and higher Hunt and Hess scales. The surgeons operated on more cases of the anterior cerebral artery as ultra-early operations. The incidence rates of DIND, IAR, severe hemodynamic instability, and cardiac arrest were 5.6, 8.3, 6.3, and 0.3%, respectively, which were not different between groups. However, the reintubation rate was higher in the ultra-early surgery cases (0 vs. 3.3%, p = 0.023). The DIND and IAR patients had poorer short-term (in hospital) outcomes.
Conclusions There were no differences in major complications between ultra-early and late craniotomy with aneurysm clipping. However, the reintubation rate was strikingly higher in the ultra-early group. Patients with major complications had early, unfavorable outcomes.
Prenatal Diagnosis of a Case of Asyndromic Tessier Class-7 Bilateral Complete Transverse Facial Cleft: Case Report with Review of Literature
Authors: Vikraman Seneesh Kumar , Yandamuri Shasmita , Desai Jay 
Published: April 2024

AbstractTransverse or lateral facial clefts are atypical and rare forms of facial clefts identified as Tessier type 7 in the classification system for orofacial clefts. They have an overall incidence of 1 in 60,000 to 300,000 live births. We report a case diagnosed at 22 weeks of gestation. The two-dimensional (2D) ultrasound examination revealed a single live fetus with a persistently open mouth, failure of visualization of lateral commissures, and mild retrognathia. The three-dimensional (3D) surface rendering of the fetal face demonstrated a bilateral horizontal facial cleft that extended from the lateral commissures to the ears. No additional anomalies were identified. Fetal karyotype and whole exome sequencing reports did not reveal any genomic imbalances. The case highlights the importance of 2D oblique and 3D imaging of the fetal face when subtle findings are detected in routine 2D views. A review of the literature is provided to enhance the understanding of the entity.
Congenital Hallux Varus: A Rare Prenatal Detection and Postnatal Management
Authors: Aloorkar Prajakta , Vemavarapu Gayathri , T. Venkatram , R. Shantisree 
Published: April 2024

AbstractCongenital hallux varus (CHV) is an uncommon anomaly of the forefoot where the big toe is positioned medially at the metatarsophalangeal joint, accompanied by a significant gap between the first and second toes. CHV is associated with difficulty in wearing clothes and footwear. CHV can cause pain that hampers the quality of life and can often be aesthetically displeasing.Although prenatal presentation is rare, CHV can be detected by antenatal ultrasound with appropriate foot examination and a high index of suspicion. Early detection and management are recommended for optimizing antenatal and postnatal management as they may reduce the chance of permanent deformity.We are herewith reporting a prenatally detected case of a CHV with polysyndactyly and its management. This is one of the few prenatally reported cases of isolated unilateral foot abnormalities.
Humeral Condylar Fractures in French Bulldogs: Prevalence of Contralateral Intracondylar Fissure, Treatment, and Outcome
Authors: Lopez de la Oliva Paula , Arnott Luke , Roses Leonor , Marshall William , Arnott Davinia 
Published: April 2024

Abstract
Objective The aim of this study was to report (1) the prevalence of contralateral humeral intracondylar GAP/HIF (HIF) in French Bulldogs with humeral condylar fractures (HCF) and (2) treatment and short- and long-term outcome in French Bulldogs with HCF.
Materials and Methods Medical records of French Bulldogs treated surgically for HCF between January 2011 and November 2022 were reviewed. Perioperative imaging, surgical technique, complications, and long-term outcome were assessed.
Results Eighty-nine dogs with HCF were included and 36/89 were diagnosed with HIF. Surgical repair was performed in all HCF and a prophylactic transcondylar screw was placed in 20/36 HIF. For prophylactic transcondylar screw placement, two dogs required immediate revision surgery. Complications occurred in 12/89 HCF, and there were major complications in 6/89 HCF. Long-term outcome evaluated by owner questionnaire (n = 27) was rated as being excellent in 18/27 dogs, good in 8/27 dogs, and fair in 1/27 dogs.
Clinical Significance Forty percent of French Bulldogs with HCF had a contralateral HIF. HIF as a cause of HCF should be considered in the French Bulldog, and a computed tomography (CT) scan of both elbows may be advisable prior to HCF repair. The complication rate of HCF surgery in the French Bulldog is significant.
Prognostic Implications of Early Prediction in Posttraumatic Epilepsy
Authors: Chen Yilun , Cappucci Stefanie P. , Kim Jennifer A. 
Published: April 2024

AbstractPosttraumatic epilepsy (PTE) is a complication of traumatic brain injury that can increase morbidity, but predicting which patients may develop PTE remains a challenge. Much work has been done to identify a variety of risk factors and biomarkers, or a combination thereof, for patients at highest risk of PTE. However, several issues have hampered progress toward fully adapted PTE models. Such issues include the need for models that are well-validated, cost-effective, and account for competing outcomes like death. Additionally, while an accurate PTE prediction model can provide quantitative prognostic information, how such information is communicated to inform shared decision-making and treatment strategies requires consideration of an individual patient's clinical trajectory and unique values, especially given the current absence of direct anti-epileptogenic treatments. Future work exploring approaches integrating individualized communication of prediction model results are needed.
A Single Standard Polyvinyl Chloride 3D Skull Model to Create the Polymethyl Methacrylate Cranioplasty Flap: A Novel and Low-Cost Technique
Authors: Prajapati Hanuman Prasad , Singh Deepak Kumar 
Published: April 2024

Abstract
Background Although, cranioplasty is a commonly performed neurosurgical procedure worldwide, the cost of available cranioplasty implants is a major issue in a low-income country like India. The aims of this study were to introduce a novel and low-cost technique using a single standard three-dimensional (3D) skull model to guide the polymethyl methacrylate (PMMA) cranioplasty flap production and to evaluate the functional and cosmetic outcomes.
Methods We retrospectively evaluated 47 cases of PMMA cranioplasty in the period from February 2019 to June 2022. A single standard 3D skull model was used to make the PMMA cranioplasty flaps. The overall cost of this PMMA implant was compared with that of other available cranioplasty implants. The functional and cosmetic outcomes were evaluated postoperatively.
Results The mean age of our patients was 37.17 ± 13.83 years and the age range was 17 to 63 years. The primary cause of surgery was trauma in the majority of cases (n = 31, 65.96%). The mean operative time was 78.55 ± 19.82 minutes. The cosmetic results were very satisfying in 46 of 47 (97.87%) patients and moderately satisfying in 1 (2.12%) patient. Overall, there were three (6.38%) complications.
Conclusion Our technique provides excellent functional and cosmetic outcomes. The overall surgical cost of these PMMA implants was lower than that of the other available cranioplasty implants. This technique is currently the most cost-effective option for cranioplasty.
Feasibility and Safety of Bridging Antiplatelet Therapy with Cangrelor in Neuro-Oncology: A Preliminary Experience
Authors: Bertolini Giacomo , Belli Laura , Mazza Stefania , Ugolotti Pietro Tito , Tadonio Iacopo , Ceccarelli Patrizia , Rossi Sandra , Ippolito Salvatore 
Published: April 2024

AbstractAntiplatelet therapy is mandatory for prevention of thrombotic events in patients with a recent history of acute coronary syndromes and/or percutaneous coronary interventions. However, if an urgent surgery is required during antiplatelet therapy, a compromise between the ischemic/thrombotic and hemorrhagic risk has to be reached. Different bridging schemes are reported in the literature, but there is no clear consensus on the optimal treatment strategy in terms of efficacy and safety. Although some indications about the perioperative management of antiplatelet therapy regarding specific surgical specializations are available, balancing the thrombotic and hemorrhagic risk on an individual basis, no evidence referring to neurosurgical or neuro-oncologic procedures is reported. Herein, we present our preliminary experience in the perioperative management of a patient who underwent a neurosurgical procedure for the resection of a primary malignant brain tumor using an intravenous P2Y12 inhibitor (cangrelor) as bridging therapy after a recent acute myocardial infarction treated with primary percutaneous coronary intervention and stenting. The oral P2Y12 inhibitor (clopidogrel) was withdrawn 5 days prior to the surgical procedure and continuous infusion of cangrelor was started 3 days before the surgery at a dose of 0.75 μg/kg/min. Cangrelor was discontinued 2 hours before surgery and resumed 72 hours after tumor resection for further 60 hours. Neither cangrelor-related bleeding nor cardiac ischemic events were observed in the perioperative period and the following 90 days, supporting data regarding the feasibility and safety of this bridging scheme. Further studies are needed to confirm our promising results.