bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relação entre a vacinação contra a COVID-19 e a qualidade do sono: Um estudo transversal
Authors: Andre Alba Karine , Santos Ana Beatriz Silva , Silva Cleyton Gomes da , Farias Kelly Soares 
Published: April 2024

Objetivos: avaliar os efeitos da vacinação contra a COVID-19 na percepção da qualidade do sono em indivíduos vacinados e não vacinados. Métodos: estudo transversal, quantitativo e descritivo, direcionado a participantes de ambos os sexos que preencheram um formulário online relacionado a informações sociodemográficas, qualidade do sono, estado de vacinação, e outros fatores ligados à qualidade de vida. Critérios de inclusão envolveram participantes maiores de 18 anos que consentiram com o Termo de Consentimento Livre e Esclarecido. O estudo foi conduzido com a aprovação do Comitê de Ética em Pesquisa da UEPB, com o número do CAAE: 57982422.1.0000.5187. Os dados foram analisados com estatística descritiva e com a matriz de correlação. Resultados: A amostra foi composta por 96 adultos, variando de 19 a 66 anos, a maioria do sexo feminino, abrangendo 77,1% da amostra. Em relação aos efeitos da vacinação sobre o sono, foi notada homogeneidade nos dados, e assim, não houve correlação entre as doses da vacina e a qualidade do sono. Quanto à sensação de tranquilidade e relaxamento após a administração das doses da vacina, 13,5% relataram sentir após a primeira dose, 28,1% após a segunda dose, 22,9% após a terceira dose e 43,8% afirmaram não perceber diferença. A pesquisa indicou que 60,4% dos participantes relataram uma melhora na qualidade de vida pós-vacinação. Considerações Finais: Estes resultados destacam a importância de disseminar os benefícios da vacina que vão além da imunização, influenciando positivamente não só o bem-estar físico, mas também psicológico e social, componentes fundamentais da qualidade de vida.
Análise do perfil de emergências neurológicas e atuação fisioterapêutica no pronto socorro
Authors: Ribeiro Karina Silva , Guimarães Felipe Pinheiro , Arcain Mariane de Freitas , Silva Maria Eduarda Bitencourt da , Zamberlan Natalia Ferreira 
Published: April 2024

As emergências neurológicas se apresentam entre as principais ocorrências em um pronto socorro, destacando a particularidade de se demonstrar a necessidade de um maior período de tempo de permanência no serviço de emergência, taxa de internação, internações em unidades de pacientes críticos, dessa forma se faz indispensável a atuação fisioterapêutica juntamente com a equipe multiprofissional no cuidado desses pacientes. O objetivo do presente estudo foi analisar o perfil de emergências neurológicas e atuação fisioterapêutica, afim de discutir sobre as condutas eficazes no atendimento fisioterapêutico frente a essa demanda no setor do pronto socorro. Trata-se de um estudo observacional, com período de doze meses, onde analisamos a idade, sexo, hipótese diagnóstica neurológica e o tratamento fisioterapêutico que foi realizado. Foram atendidos na unidade de emergência nesse período 1619 pacientes, sendo 192 pacientes apresentavam o perfil de emergências neurológicas, apresentando um percentual de 11,85% em relação ao total. Em relação as patologias encontradas nos pacientes adultos 4 foram mais prevalentes, sendo: Acidente Vascular Cerebral Isquemico (50%), Acidente Vascular Cerebral Hemorrágico (17,7%), Crise Convulsiva (13%) e Traumatismo Cranioencefálico (13%). As abordagens fisioterapêuticas observadas pelo estudo demonstraram um enfoque maior em condutas relacionadas ao sistema respiratório, e uma menor prevalência de atuação voltada ao sistema motor e a mobilização precoce, o que é justificado pelo fato da ocorrência de prioridade em situações de intercorrências que promovem riscos de vida e são comumento prevalentes nesse setor, interferindo diretamente em condutas voltadas para a mobilização precoce.
The Relationship of Parental Support with Student Learning Outcomes in Social Studies Learning Class V at SD Negeri 01 Sri Basuki Way Kanan 2021/2022
Authors: Mustofia Ningrum Anim , Rahma Pratiwi Emy Yunita 
Published: April 2024

In social studies learning at the basic education level such as elementary school (SD), good social interaction and mutual support between parents and children are needed. However, there are still many parents who do not provide support or tutoring for their children so that their children do not get proper learning outcomes as expected. This study aims to determine the relationship between parental support and student learning outcomes in Social Studies learning in Class V at SD Negeri 01 Sri Basuki Way Kanan. This type of research is correlational research with quantitative methods. The sample in this study amounted to 40 fifth grade students of SD Negeri 01 Sri Basuki in the 2021/2022 academic year. The instruments in this study were questionnaires and documentation. Data collection techniques using questionnaires and documentation. The data analysis technique uses the "Product Moment Correlation" formula. The results of hypothesis testing obtained that the calculated r value is greater than the r table value, then the hypothesis proposed by the researcher is accepted, so it can be concluded that there is a significant positive relationship between parental support and student learning outcomes in social studies learning class V at SD Negeri 01 Sri Basuki Way Kanan.

Keywords: Learning Outcomes, Parental Support, Social Studies
Pengaruh Model Pembelajaran Two Stay Two Stray (Tsts) Terhadap Hasil Belajar Siswa Pada Materi Pkn Kelas III SDN Kesamben 2 Ngoro Jombang
Authors: Kamelia Liza , Rahma Pratiwi Emy Yunita , Dwinata Anggara 
Published: April 2024

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Currently there are still many teachers who use the lecture method, to use the two stray two stay learning model is still minimally used during learning. In this study, researchers wanted to find out whether the two stay two stray learning model had an effect on the learning outcomes of these students, this was the purpose of the study. This study used quantitative methods with a type of one-group pretest-postest design. The sample of this study was 16 students. Data collection methods are tests, questionnaires and documentation. The results of this study showed that before being given the action obtained an average value of 66.88 and after getting the action increased to 86.25. This study has a significant effect of 0.000. A significant value indicating 0.000 < 0.05 so that Hâ‚€ is rejected and Hâ‚ is accepted. This means that there is a positive influence and response from the use of the Two Stay Two Stray (TSTS) learning model on student learning outcomes in Class III PKN material at SDN Kesamben 2 Ngoro Jombang.
The Effectiveness of Learning Number Heads Together on Critical Thinking of Class IV Students Learning PPKn
Authors: Fatimah Siti 
Published: April 2024

The general learning objectives as well as the members of the study group's social, physical, and mental characteristics are all part of the effectiveness of learning. Students' critical thinking abilities may be improved by learning number heads collectively. The capacity for critical thinking entails the capacity for reasoned, reasonable thought as well as the capacity for problem-solving. Students can develop their personalities and be able to articulate their ideas by using critical thinking. The type of research that was employed was descriptive quantitative research, and the purpose of this study was to describe and describe in a factual, methodical, and precise manner the usefulness of using number heads alongside learning to foster critical thinking in elementary school kids. It is well known that the t-count, which is 6,007 > 2,093, exceeds the t-table. with a 2-tailed sig. value of 0.000. H1 is accepted and H0 is denied because it can be observed that the significant value of 0.000 is less significant than the significance of 0.05 (0.000 0.05). This indicates that there is a considerable difference in the effectiveness of teaching pupils to think critically before and after using number heads together.
PENGARUH RETURN ON EQUITY DAN DEBT TO EQUITY RATIO TERHADAP NILAI PERUSAHAAN DENGAN KEBIJAKAN DIVIDEN SEBAGAI VARIABEL MODERASI
Authors: Pinandita Candra Pramula 
Published: April 2024

The purpose of this research was to know the influence of the financial performance of firm value with dividend policy as moderating variables. The variables used were Return On Equity, Debt to Equity Ratio as independent variable, Firm Value as dependent variable and Dividend Policy as moderating variable. Sampling method used purposive sampling in manufacturing companies listed LQ-45 index from 2011-2015 and it was obtained 10 companies of them are used as the samples. This study used secondary data with documentation as collect data method. This study used simple regression and absolute residual as data analysis. The result showed that ROE had significant positive effect on PBV, DPR had significant positive effect on relationship between ROE and PBV, DER had significant positive effect on PBV, DPR had significant positive effect on relationship between ROE and PBV. The results of this research are expected to help management consider investment opportunities company in the future
Case Report of a Hidden Intruder—Extremely Rare Presentation of Hydatidosis as a Nuchal Tumoural Mass
Authors: Voicu Dragoș F. , Popazu Constantin , Râșnoveanu Delia Mihaela , Mihalache Daniela , Toma Alexandra 
Published: April 2024

Introduction: The parasitic tapeworm impersonated by the larvae of Echinococcus granulosus represents the aetiology of the hydatid pathology. The predilect site of invasion is the liver, but there are other cases of different localization all over the body, regardless of the type of invaded tissue. Soft tissue hydatidosis can be a real challenge for the clinician in terms of the diagnosis, and it might generate various complications such as anaphylactic shock. The aim of the present work is to illustrate a unique case of primary hydatidosis located in the nuchal region.Case Report: We report the case of a 68-year-old male patient, a zootechnic, who presented at the hospital with a tumoural mass (dimension: about 12/10 cm) located in the nuchal region. The complex approach needed consisted of surgical therapy along with histopathological confirmation of the diagnostic and antiparasitic medication, which led to a complete recovery with a low probability of recurrence.Discussion: Encounters with patients with primary soft tissue hydatidosis are exceptionally rare, but the surgeon must take into consideration this clinical diagnosis, especially for patients located in an endemic region with occupations that might have exposed the patient to this type of parasite.
Characterization of polyamine metabolism predicts prognosis, immune profile, and therapeutic efficacy in lung adenocarcinoma patients
Authors: Li Zhouhua , Wu Yue , Yang Weichang , Wang Wenjun , Li Jinbo , Huang Xiaotian , Yang Yanqiang , Zhang Xinyi , Ye Xiaoqun 
Published: April 2024

BackgroundPolyamine modification patterns in lung adenocarcinoma (LUAD) and their impact on prognosis, immune infiltration, and anti-tumor efficacy have not been systematically explored.MethodsPatients from The Cancer Genome Atlas (TCGA) were classified into subtypes according to polyamine metabolism-related genes using the consensus clustering method, and the survival outcomes and immune profile were compared. Meanwhile, the geneCluster was constructed according to the differentially expressed genes (DEGs) of the subtypes. Subsequently, the polyamine metabolism-related score (PMRS) system was established using the least absolute shrinkage and selection operator (LASSO) multivariate regression analysis in the TCGA training cohort (n = 245), which can be applied to characterize the prognosis. To verify the predictive performance of the PMRS, the internal cohort (n = 245) and the external cohort (n = 244) were recruited. The relationship between the PMRS and immune infiltration and antitumor responses was investigated.ResultsTwo distinct patterns (C1 and C2) were identified, in which the C1 subtype presented an adverse prognosis, high CD8+ T cell infiltration, tumor mutational burden (TMB), immune checkpoint, and low tumor immune dysfunction and exclusion (TIDE). Furthermore, two geneClusters were established, and similar findings were observed. The PMRS, including three genes (SMS, SMOX, and PSMC6), was then constructed to characterize the polyamine metabolic patterns, and the patients were divided into high- and low-PMRS groups. As confirmed by the validation cohort, the high-PMRS group possessed a poor prognosis. Moreover, external samples and immunohistochemistry confirmed that the three genes were highly expressed in tumor samples. Finally, immunotherapy and chemotherapy may be beneficial to the high-PMRS group based on the immunotherapy cohorts and low half-maximal inhibitory concentration (IC50) values.ConclusionWe identified distinct polyamine modification patterns and established a PMRS to provide new insights into the mechanism of polyamine action and improve the current anti-tumor strategy of LUAD.
Economy of scale for green hydrogen-derived fuel production in Nepal
Authors: Thapa Biraj Singh , Pandey Bishnu , Ghimire Rahul 
Published: April 2024

Opportunity for future green hydrogen development in Nepal comes with end-use infrastructural challenges. The heavy reliance of industries on fossil fuels (63.4%) despite the abundance of hydroelectricity poses an additional challenge to the green transition of Nepal. The presented work aims to study the possibility of storing and utilizing spilled hydroelectricity due to runoff rivers as a compatible alternative to imported petroleum fuels. This is achieved by converting green hydrogen from water electrolysis and carbon dioxide from carbon capture of hard-to-abate industries into synthetic methane for heating applications via the Sabatier process. An economy-of-scale study was conducted to identify the optimal scale for the reference case (Industries in Makwanpur District Nepal) for establishing the Synthetic Natural Gas (SNG) production industry. The techno-economic assessment was carried out for pilot scale and reference scale production unit individually. Uncertainty and sensitivity analyses were performed to study the project profitability and the sensitivity of the parameters influencing the feasibility of the production plant. The reference scale for the production of Synthetic Natural Gas was determined to be 40 Tons Per Day (TPD), with a total capital investment of around 72.15 Million USD. Electricity was identified as the most sensitive parameter affecting the levelized cost of production (LCOP). The 40 TPD plant was found to be price competitive to LPG when electricity price is subsidized below 3.55 NPR/unit (2.7 c/unit) from 12 NPR/unit (9.2 c/unit). In the case of the 2 TPD plant, for it to be profitable, the price of electricity must be subsidized to well below 2 NPR/kWh. The study concludes that the possibility of SNG production in Nepal is profitable and price-competitive at large scales and at the same time limited by the low round efficiency due to conversion losses. Additionally, it was observed that highly favorable conditions driven by government policies would be required for the pilot-scale SNG project to be feasible.
Single-cell RNA sequencing and ATAC sequencing identify novel biomarkers for bicuspid aortic valve-associated thoracic aortic aneurysm
Authors: Liu Xu-Wen , Wang Pei , Zhang Li , Zhu Yu , Zhai Jun-Yu , Wang Chang-Nan , Li Jun , Xiao Jian 
Published: April 2024

IntroductionBicuspid aortic valve (BAV) is the most prevalent congenital cardiovascular defect and known to cause thoracic aortic aneurysms (TAAs). To improve our understanding of BAV pathogenesis, we characterized the cellular composition of BAV tissues and identified molecular changes in each cell population.MethodsTissue samples from two patients with BAV and two heart transplant donors were analyzed using single-cell RNA sequencing, assay for transposase-accessible chromatin using sequencing, and weighted gene coexpression network analysis for differential gene analysis. TAA-related changes were evaluated by comparing the proportion of each cell type and gene expression profiles between TAA and control tissues. Further, by combining our single-cell RNA sequencing data with publicly available data from genome-wide association studies, we determined critical genes for BAV.ResultsWe found 20 cell subpopulations in TAA tissues, including multiple subtypes of smooth muscle cells, fibroblasts, macrophages, and T lymphocytes. This result suggested that these cells play multiple functional roles in BAV development. Several differentially expressed genes, including CD9, FHL1y, HSP90AA1, GAS6, PALLD, and ACTA2, were identified.DiscussionWe believe that this comprehensive assessment of the cellular composition of TAA tissues and the insights into altered gene expression patterns can facilitate identification of novel diagnostic biomarkers and therapeutic targets for BAV-associated TAA.
Expression profiling of ALOG family genes during inflorescence development and abiotic stress responses in rice (Oryza sativa L.)
Authors: Liu Zhiyuan , Fan Zhenjiang , Wang Lei , Zhang Siyue , Xu Weichen , Zhao Sijie , Fang Sijia , Liu Mei , Kofi Sackitey Mark , Zhang Shuangxi , Kang Ningning , Ai Hao , Li Ruining , Feng Tingting , Wei Shuya , Zhao Heming 
Published: April 2024

The ALOG (Arabidopsis LSH1 and Oryza G1) family proteins, namely, DUF640 domain-containing proteins, have been reported to function as transcription factors in various plants. However, the understanding of the response and function of ALOG family genes during reproductive development and under abiotic stress is still largely limited. In this study, we comprehensively analyzed the structural characteristics of ALOG family proteins and their expression profiles during inflorescence development and under abiotic stress in rice. The results showed that OsG1/OsG1L1/2/3/4/5/6/7/8/9 all had four conserved helical structures and an inserted Zinc-Ribbon (ZnR), the other four proteins OsG1L10/11/12/13 lacked complete Helix-1 and Helix-2. In the ALOG gene promoters, there were abundant cis-acting elements, including ABA, MeJA, and drought-responsive elements. Most ALOG genes show a decrease in expression levels within 24 h under ABA and drought treatments, while OsG1L2 expression levels show an upregulated trend under ABA and drought treatments. The expression analysis at different stages of inflorescence development indicated that OsG1L1/2/3/8/11 were mainly expressed in the P1 stage; in the P4 stage, OsG1/OsG1L4/5/9/12 had a higher expression level. These results lay a good foundation for further studying the expression of rice ALOG family genes under abiotic stresses, and provide important experimental support for their functional research.
Gut microbiome, T cell subsets, and cytokine analysis identify differential biomarkers in tuberculosis
Authors: Chai Yinghui , Liu Xin , Bai Guangliang , Zhou Nannan , Liu Danfeng , Zhang Xiaomeng , Li Min , Li Kang , Lei Hong 
Published: April 2024

IntroductionThe gut microbiota, T cell subsets, and cytokines participate in tuberculosis (TB) pathogenesis. To date, the mechanisms by which these factors interactively promote TB development at different time points remain largely unclear. In the context of this study, We looked into the microorganisms in the digestive tract, T cell types, and cytokines related to tuberculosis.MethodsAccording to QIIME2, we analyzed 16SrDNA sequencing of the gut microbiome on the Illumina MiSeq. Enzyme-linked immunosorbent assay was used to measure the concentrations of cytokines.ResultsWe showed the presence of 26 identifiable differential microbiomes in the gut and 44 metabolic pathways between healthy controls and the different time points in the development of TB in patients. Five bacterial genera (Bacteroides, Bifidobacterium, Faecalibacterium, Collinsella, and Clostridium) were most closely associated with CD4/CD8, whereas three bacterial taxa (Faecalibacterium, Collinsella, and Clostridium) were most closely associated with CD4. Three bacterial taxa (Faecalibacterium, Ruminococcus, and Dorea) were most closely associated with IL-4. Ruminococcus was most closely associated with IL-2 and IL-10.ConclusionDiverse microorganisms, subsets of T cells, and cytokines, exhibiting varying relative abundances and structural compositions, were observed in both healthy controls and patients throughout distinct phases of tuberculosis. Gaining insight into the function of the gut microbiome, T cell subsets, and cytokines may help modulate therapeutic strategies for TB.
Peripheral CD4+ T cells correlate with response and survival in patients with advanced non-small cell lung cancer receiving chemo-immunotherapy
Authors: Yang Xin , Li Qiao , Zeng Tianyang 
Published: April 2024

BackgroundThe aim of the present study was to explore the potential of peripheral immune cells in predicting the response and prognosis of patients with advanced non-small cell lung cancer (NSCLC) receiving anti-PD-1 immunotherapy and platinum-based chemotherapy.Participants and MethodsWe utilized flow cytometry to examine the levels and dynamics of blood immune cells in 79 advanced NSCLC patients treated with the chemoimmunotherapy between December 2019 and January 2022. The pre- and post-treatment blood samples were collected within 3 days prior to the initiation of the first and third cycle of combination treatment, respectively. Progression-free survival (PFS) and overall survival (OS) analyses were conducted using Kaplan-Meier method and Cox regression models.ResultsThe pre-treatment CD4+/Total T cells ratio was significantly higher in responders than non-responders (P &lt; 0.05). The levels of pre-treatment total lymphocytes (P = 0.012), total B lymphocytes (P = 0.025), and NK cells (P = 0.022), and post-treatment NK cells (P = 0.011) and NKT cells (P = 0.035) were significantly associated with OS. Post-treatment CD8+/Total T cells ratio was positively correlated with OS (P = 0.038). In multivariate analysis, post-treatment NK cells and post-treatment CD4+CD8+/Total T cells ratio were negatively associated with OS (hazard ratio [HR] = 10.30, P = 0.038) and PFS (HR = 1.95, P = 0.022), respectively. Notably, significantly positive correlations were observed between CD4+/Total T cells ratio and prognosis both before and after treatment (P &lt; 0.05).ConclusionTo summarize, our finding reveals that high CD4+/total T cells ratio was associated with favorable response and prognosis, highlighting its potential as a predictive biomarker to guide the selection of likely responders to platinum and anti-PD-1 combination therapy.