bluuebunny/crossref_metadata_2025_split huggingface dataset:
Selective Ring‐Opening Amination of Isochromans and Tetrahydroisoquinolines
Authors: Niu Changhao , Zhang Zheng , Li Qi , Cheng Zengrui , Jiao Ning , Zhang Chun 
Published: March 2024

AbstractThe molecular structure‐editing through selective C−C bond cleavage allows for the precise modification of molecular structures and opens up new possibilities in chemical synthesis. By strategically cleaving C−C bonds and editing the molecular structure, more efficient and versatile pathways for the synthesis of complex compounds could be designed, which brings significant implications for drug development and materials science. o‐Aminophenethyl alcohols and amines are the essential key motifs in bioactive and functional material molecules. The traditional synthesis of these compounds usually requires multiple steps which could generate inseparable isomers and induce low efficiencies. By leveraging a molecular editing strategy, we herein reported a selective ring‐opening amination of isochromans and tetrahydroisoquinolines for the efficient synthesis of o‐aminophenethyl alcohols and amines. This innovative chemistry allows for the precise cleavage of C−C bonds under mild transition metal‐free conditions. Notably, further synthetic application demonstrated that our method could provide an efficient approach to essential components of diverse bioactive molecules.
Self‐Assembled Molecules with Asymmetric Backbone for Highly Stable Binary Organic Solar Cells with 19.7 % Efficiency
Authors: Yu Xueliang , Ding Pengfei , Yang Daobin , Yan Pengyu , Wang Hongqian , Yang Shuncheng , Wu Jie , Wang Zhongqiang , Sun He , Chen Zhenyu , Xie Lin , Ge Ziyi 
Published: March 2024

AbstractThe hole‐transporting material (HTM), poly (3,4‐ethylene dioxythiophene) poly(styrene sulfonate) (PEDOT : PSS), is the most widely used material in the realization of high‐efficiency organic solar cells (OSCs). However, the stability of PEDOT : PSS‐based OSCs is quite poor, arising from its strong acidity and hygroscopicity. In addition, PEDOT : PSS has an absorption in the infrared region and high highest occupied molecular orbital (HOMO) energy level, thus limiting the enhancement of short‐circuit current density (Jsc) and open‐circuit voltage (Voc), respectively. Herein, two asymmetric self‐assembled molecules (SAMs), namely BrCz and BrBACz, were designed and synthesized as HTM in binary OSCs based on the well‐known system of PM6 : Y6, PM6 : eC9, PM6 : L8‐BO, and D18 : eC9. Compared with BrCz, BrBACz shows larger dipole moment, deeper work function and lower surface energy. Moreover, BrBACz not only enhances photon harvesting in the active layer, but also minimizes voltage losses as well as improves interface charge extraction/ transport. Consequently, the PM6 : eC9‐based binary OSC using BrBACz as HTM exhibits a champion efficiency of 19.70 % with a remarkable Jsc of 29.20 mA cm−2 and a Voc of 0.856 V, which is a record efficiency for binary OSCs so far. In addition, the unencapsulated device maintains 95.0 % of its original efficiency after 1,000 hours of storage at air ambient, indicating excellent long‐term stability.
Fabrication of high‐performance acrylate grouting materials from tailor made magnesium acrylate solutions
Authors: Wei Daidong , Zhu Kaipeng , Li Huizhi , Zeng Juanjuan , Li Shiqiang , Xue Wei 
Published: March 2024

AbstractAcrylate grouting (AG) material is a low‐viscosity aqueous solution capable of forming an elastic water‐plugging gel after being injected into seepage cracks. This study highlights the fabrication and performance of AG materials, specifically emphasizing the use of magnesium acrylate (MgDA) as the principal precursor for the polymer gel network. Additionally, 2‐(dimethylamino)ethyl methacrylate (DMAEMA) serves as a bifunction crosslinker and accelerator, while sodium persulfate and potassium ferricyanide act as initiator and retarder, respectively. AG materials are made of these four key ingredients mixed in an aqueous solution, and then polymerized into a highly elastic water‐plugging gel. Our systematic investigation indicated that the MgDA and DMAEMA concentrations significantly influence the performance of the AG material. The optimized AG material formulation containing 24% MgDA and 1.4% DMAEMA, exhibited an elongation at break of 1040%, a water absorption of 67% and a compressive strength of 363 kPa in grouted sand. The gel time could be adjusted from under 20 s to more than 20 min, offering versatility to meet various application requirements. Beyond its good bonding performance and superior extrusion resistance, the AG materials displayed excellent water‐plugging effect. Impressively, even after extending the closed water test to 360 days, the gel displayed no significant change in color or signs of degradation, and the treated crack remained in a deep dry state with no evidence of leakage, confirming the AG material's superior durability. With its advantageous permeability and excellent water‐plugging effect, the AG material is well‐suited for applications in micro‐crack sealing, seepage prevention and stratum reinforcement grouting.
Novel protective coating based on the prepared Cu (II) and Co (II)‐containing linoleic poly(esteramide) as new anticorrosive and antimicrobial binders for industrial applications
Authors: Hamza S. F. , Elsawy M. M. , Abdelsalam Fatma H. , Sharaf Mohamed H. , Abd El‐Wahab H. 
Published: March 2024

AbstractThis article focused on the preparation of Cu, Co (II)‐containing linoleic‐based poly(ester amide) resin and studied their use as new binders for paint formulation. The metal‐containing LPEA was carried out by in situ condensation polymerization reaction between hydroxyethyl linoleic fatty amide diol (HELA), phthalic anhydride (PA), and Cu, Co acetate. The structure of the prepared resins was confirmed by FTIR and 1H NMR spectral studies. Physicochemical, thermal analysis (TGA), surface morphology (SEM), and elemental composition (EDX) were studied by standard methods. The physicomechanical, antimicrobial, and corrosion/chemical resistance performance tests were also conducted to evaluate their coating properties. These studies revealed that (i) the incorporation of Cu, Co (II) has a significant influence on structural and physicochemical aspects. The paint formulation based on Cu, Co (II) containing LPEA showed very good results according to the corrosion resistant test evalution. (iii) Antimicrobial tests of all prepared resins were performed by agar diffusion method against Staphylococcus aureus, Bacillus cereus, Escherichia coli, Klebsiella pneumonia, and pathogenic fungal strain using standard controlled medication, ciprofloxacin/fluconazole for the comparison. (iv) Cu, Co (II) containing LPEA serve as novel binders and promising candidates for use as binders for protective coating material.
Distribution and diversity of elasmobranchs in the Sea of Marmara: A 2023 status report
Authors: Karadurmuş Uğur , Sarı Mustafa 
Published: March 2024

Abstract
Elasmobranchs, encompassing an array of sharks and rays, confront a threat of extinction on a global scale. The Sea of Marmara (SoM) stands out as a critical refuge for these endangered species.
This study harnesses data derived from comprehensive trawl surveys, representing the first area‐based evaluation of the elasmobranchs inhabiting the SoM. Sampling protocols were carried out at 10 separate stations along the 980‐km coastline of the SoM, each bounded by different ecological characteristics and anthropogenic influences.
A total of eight shark species and six ray species were caught in the towed area of the entire the SoM. Notably, Scyliorhinus canicula and near‐threatened Raja clavata constitute more than 50% of the total abundance. Additionally, rare, and critically endangered species, including the Oxynotus centrina, Squatina squatina, Dipturus batis, and Myliobatis aquila, were documented, expanding our knowledge of their presence in the region.
Spatial distribution heterogeneity was pronounced within species.
Size distributions were species‐specific, and the presence of both juvenile and adult individuals suggested successful reproduction and growth.
Records expand the known size range in the SoM for six shark and three ray species. It also provides first‐size information based on the total length of the S. stellaris and D. batis.
Additionally, the urgent need for field‐based conservation efforts is highlighted, citing a previously unidentified important sensitive areas located in the southern part of the SoM.
Enhancing short‐chain fatty acids production via acidogenic fermentation of municipal sewage sludge: Effect of sludge characteristics and peroxydisulfate pre‐oxidation
Authors: Liu Faxin , Cheng Wen , Xu Jianping , Wan Tian , Wang Min , Ren Jiehui , Ning Maomao , Zhang Hui , Zhou Xiaoping 
Published: March 2024

AbstractThis study first employed a combined pretreatment of low‐dose peroxy‐disulfate (PDS) and initial pH 10 to promote short‐chain fatty acids (SCFAs) production via acidogenic fermentation using different types of sewage sludge as substrates. The experimental results showed that the yield of maximal SCFAs and acetate proportion after the combined pretreatment were 1513.82 ± 28.25 mg chemical oxygen demand (COD)/L and 53.64%, and promoted by 1.28 and 1.56 times higher, respectively, compared to the sole initial pH 10 pretreatment. Furthermore, in terms of the disintegration degree of sewage sludge, it increased by more than 18% with the combined pretreatment compared to the pretreatment of sole initial pH 10. Waste‐activated sludge (WAS) from A2/O and Bardenpho processes were more biodegradable, explained by the 1.47‐ and 1.35‐times higher disintegration rate than those from oxidation ditch and they favored acetate dominant fermentation. Correlation analysis revealed a strong correlation (p ≤ 0.01) between SCFAs production and soluble COD, total proteins, proteins in soluble‐extracellular polymeric substances (SEPS), total polysaccharides, and polysaccharides in SEPS. Mechanism explorations showed that preoxidation with PDS enhanced the solubilization and biodegradability of complex substrates, and altered the microbial community structure during the fermentation process. Firmicutes and Tetrasphaera were proven to play a key role in improving SCFA production, especially in promoting acetate production by converting additional SCFAs into acetate. Additionally, the addition of PDS greatly promoted sulfur and iron‐related metabolic activities. Finally, the combined pretreatment was estimated to be a cost‐effective solution for reutilizing and treating Fe‐sludge.
How online data informs forensic mental health evaluations of sexual behavior: An overview
Authors: Morgan Camille , Klein Carolina 
Published: March 2024

AbstractThe Internet plays a pervasive role in modern life including the expression of human sexuality and sexual offending. A range of online sexual activities may be of interest in forensic mental health evaluations (FMHE), including those which are clearly illegal or those which are legal but functionally problematic. Online sexual offenses will clearly prompt forensic evaluators to consider the role of the Internet in these offending behaviors. The Internet may also be relevant in forensic evaluations of contact sexual offending including informing on history of mixed or cross‐over offending, and Internet‐facilitated contact offenses. A review of Internet‐data may span several online domains, many of which provide the user with substantial anonymity and would likely not be available to the evaluator unless provided through the process of discovery. Early guidelines for the review of Internet‐data in FMHEs have been proposed and support the Internet as a useful source of collateral data in the conduct of forensic evaluations of sexual behavior.
Global burden, risk factors, and trends of non‐Hodgkin lymphoma: A worldwide analysis of cancer registries
Authors: Huang Junjie , Chan Sze Chai , Lok Veeleah , Zhang Lin , Lucero‐Prisno Don Eliseo , Xu Wanghong , Zheng Zhi‐Jie , Elcarte Edmar , Withers Mellissa , Wong Martin C. S. 
Published: March 2024

AbstractBackgroundNon‐Hodgkin lymphoma (NHL) accounts for 90% of all malignant lymphomas. This study aimed to evaluate the global incidence, mortality, associated risk factors, and temporal trends of NHL by sex, age, and country.MethodsData from 185 countries globally were used for analysis. NHL incidence and mortality were collected via the GLOBOCAN (2020), CI5 series I‐X, WHO mortality database, the Nordic Cancer Registries, and the SEER Program. The WHO Global Health Observatory provided country‐level, age‐standardized prevalence of lifestyle and metabolic risk factors. Trends were examined and reported based on average annual percentage change (AAPC) calculated using Joinpoint regression analysis. Incidence and AAPC are based on data for the last 10 years across countries.ResultsGlobally, age‐standardized incidence and mortality rates for NHL were recorded at 5.8 and 2.6 per 100,000 individuals, respectively. At country‐level, NHL incidence was significantly associated with various factors, including HDI (Human Development Index), GDP per capita, prevalence of tobacco and alcohol consumption, sedentary lifestyle, obesity, hypertension, diabetes and hypercholesterolaemia. Rising trend in NHL incidence was observed, with the highest increase recorded in Estonia (AAPCmale = 4.15, AAPCfemale = 5.14), Belarus (AAPCfemale = 5.13), and Lithuania (AAPCfemale = 4.68). While overall NHL mortality has been decreasing, certain populations experienced increased mortality over the decade. In Thailand, AAPC for mortality was 31.28% for males and 30.26% for females. Estonia saw an AAPC of 6.46% for males, while Slovakia experienced an AAPC of 4.24% for females. Colombia's AAPC was 1.29% for males and 1.51% for females.ConclusionsThis study indicates a rising trend of NHL incidence over the past decade‐ particularly in developed countries, older males, and younger populations. Further research should investigate deeper insights into specific etiology and prognosis of NHL across subtypes, and potential contributors towards these epidemiologic trends.
α‐Glucosidase Inhibitory Components from Garcinia pedunculata Fruits
Authors: Zou Deli , Liu Lei , Liu Fangshen , Li Dahong , Hua Huiming 
Published: March 2024

AbstractFrom Garcinia pedunculata Roxb. fruits, two undescribed aromatic compounds including a benzofuran and a depsidone derivative, and a new natural product, together with four known compounds were isolated. Through the analysis of spectroscopic data, high resolution mass spectrum and calculated nuclear magnetic resonance, their structures were determined. The α‐glucosidase inhibitory activity of the isolates was evaluated. And compound 3 exhibited a moderate inhibitory effect on α‐glucosidase. The molecular docking of compound 3 was performed to elucidate the interaction with α‐glucosidase.
Research Progress on the Assembly of Large DNA Fragments
Authors: Tan Wei , Miao Qing , Jia Xuemei , Liu Ying , Li Shuai , Yang Dayong 
Published: March 2024

AbstractSynthetic biology, a newly and rapidly developing interdisciplinary field, has demonstrated increasing potential for extensive applications in the wide areas of biomedicine, biofuels, and novel materials. DNA assembly is a key enabling technology of synthetic biology and a central point for realizing fully synthetic artificial life. While the assembly of small DNA fragments has been successfully commercialized, the assembly of large DNA fragments remains a challenge due to their high molecular weight and susceptibility to breakage. This article provides an overview of the development and current state of DNA assembly technology, with a focus on recent advancements in the assembly of large DNA fragments in Escherichia coli, Bacillus subtilis, and Saccharomyces cerevisiae. In particular, the methods and challenges associated with the assembly of large DNA fragment in different hosts are highlighted. The advancements in DNA assembly have the potential to facilitate the construction of customized genomes, giving us the ability to modify cellular functions and even create artificial life. It is also contributing to our ability to understand, predict, and manipulate living organisms.
Secondary syphilis presenting as fever of unknown origin
Authors: Wilding Hannah Eloise , Hays Amy 
Published: March 2024

Key Clinical MessageA thirty‐eight year‐old male presented with a seven‐week history of persistent fever accompanied by recurrent night sweats, chills, arthralgias, headache, and chest tightness.Initial laboratory testing showed non‐specific elevation of inflammatory markers, but was otherwise unremarkable.A palmar rash developed one week later, prompting testing for syphilis. Fluorescent treponemal antibody absorption (FTA‐ABS) and rapid plasma reagin (RPR) tests were both positive.Penicillin G was administered and the patient recovered uneventfully.Our case emphasizes the need for increased syphilis screening to ensure proper diagnosis and prompt treatment.
Walking ability after resection of soft tissue sarcoma of the thigh and the sciatic nerve
Authors: Isobe Mizuki , Hakozaki Michiyuki , Kaneuchi Yoichi , Ogawa Itaru , Suzuki Takeo , Sasaki Nobuyuki , Kameda Takuya , Matsumoto Yoshihiro 
Published: March 2024

Key Clinical MessageWalking ability may be fairly well maintained after sciatic nerve resection combined with wide resection of soft tissue sarcoma, therefore, surgeons should not hesitate to perform sciatic nerve resection to achieve an adequate surgical margin.
Multiple renal angiomyolipomas with asymptomatic nontraumatic pulmonary fat embolus: A case report
Authors: Soleimani Hourieh , Pezeshki Rad Masoud , Farrokh Donya , Hassannejad Ehsan , Payandeh Asma , Zahedi Sepideh , Karimabadi Neda 
Published: March 2024

Key Clinical MessageAlthough retroperitoneal bleeding and massive hematuria are potential complications of angiomyolipoma (AML), the pulmonary embolism as a presenting symptom is extremely rare. It is important to be aware that benign AMLs can present with pulmonary fat embolism.
Progressive multifocal leukoencephalopathy in a lung transplant recipient
Authors: Sakizadeh Jason , Davis Michael J. , Fontana Lauren 
Published: March 2024

Key Clinical MessageProgressive multifocal leukoencephalopathy (PML) is a rare and fatal demyelinating disease of the central nervous system (CNS). The case we describe highlights the importance of considering a diagnosis of PML early (<1 year) after lung transplant.
A symphony of anomalies: Isolated pulmonary artery agenesis meets congenital lung hypoplasia
Authors: Ansari Nida , Ozgur Sacide S. , Alcantara Alan , Sultana Yasmeen 
Published: March 2024

Key Clinical MessageIsolated agenesis of pulmonary arteries with congenital lung hypoplasia is rare. It can be found in childhood or adulthood if asymptomatic. We present a patient with congenital right lung hypoplasia with an absent right pulmonary artery.
Efficient Electrocatalytic H2 Production by Immobilized Co(III)‐myoglobin
Authors: Meglioli Mirco , Di Rocco Giulia , Ranieri Antonio , Bortolotti Carlo Augusto , Sola Marco , Battistuzzi Gianantonio , Borsari Marco 
Published: March 2024

AbstractThe thermodynamics and kinetics of heterogeneous electron transfer (ET) for Co‐substituted horse myoglobin (Co−Mb) and its derivatives with ammonia and imidazole as heme axial ligands were studied with cyclic voltammetry on a pyrolytic graphite electrode along with their ability to mediate the electro‐catalytic production of H2. All the proteins experience a non‐diffusive electrochemical regime as electrode‐bound species. The adsorbed Co−Mb construct carries out the electro‐catalytic reduction of water protons to H2 with a good efficiency under anaerobic conditions thus yielding a simple and tunable system for H2 production. Replacement of H2O as Co axial ligand by ammonia and imidazole significantly lowers the catalytic currents for H3O+/H2O reduction to H2. The E°’ values of the Co(III)/Co(II) redox couple for all species are mainly determined by the enthalpic contribution. Differences were found in the kinetics of ET for the different protein adducts due to changes in the activation enthalpies. However, all species share the same distance of about 14 Å from the electrode surface to the Co(III)/Co(II) center determined using the Marcus model, consistent with a non‐denaturing adsorption of the protein.
Surface Topological Glycosylation‐Mediated Mucoadhesion of Bacteria†
Authors: Kuang Xiao , Liu Xiaobing , Chen Ju , Lv Wenyan , Zhang Mengmeng , Chen Huan , Wu Feng , Liu Jinyao 
Published: March 2024

Comprehensive SummarySugar moieties present on bacterial surface serve as pivotal regulators of bacterial activity. Precisely adjusting the abundance and distribution of surface sugar moieties can offer an important approach to manipulating bacterial behavior, but has been proven to be difficult. Herein, surface topological glycosylation is reported to mediate the interaction of bacteria with mucous layer. Alkynes functionalized by sugar moieties with different branching are synthesized through iterative Michael addition and amide condensation reactions. By a copper‐catalyzed azide‐alkyne cycloaddition, the resulting compounds with different branching structures can be attached onto bacterial surface that is modified with azido groups. As a proof‐of‐concept study, a set of topologically glycosylated probiotics (TGPs) is prepared using linear, two‐branched, and tetra‐branched compounds, respectively. The interaction between mucin and TGPs was studied and the results demonstrate that, compared to unmodified bacteria, TGPs exhibit an enhanced adhesive capacity to mucin, which increases with the branching numbers. Similar binding trend is observed in ex vivo colonic mucus adhesion experiments and bacteria glycosylated with tetra‐branched compounds display the highest binding efficiency. This work proposes a chemical method to tune the abundance and distribution of sugar moieties on bacteria, providing unique significant insights into the manipulation of bacterial behavior through surface modification.
Biochemical characterization of cardiac α‐actin mutations A21V and D26N implicated in hypertrophic cardiomyopathy
Authors: Greve Johannes N. , Schwäbe Frederic V. , Taft Manuel H. , Manstein Dietmar J. 
Published: March 2024

AbstractFamilial hypertrophic cardiomyopathy (HCM) affects .2% of the world's population and is inherited in an autosomal dominant manner. Mutations in cardiac α‐actin are the cause in 1%–5% of all observed cases. Here, we describe the recombinant production, purification, and characterization of the HCM‐linked cardiac α‐actin variants p.A21V and p.D26N. Mass spectrometric analysis of the initially purified recombinant cardiac α‐actin variants and wild‐type protein revealed improper N‐terminal processing in the Spodoptera frugiperda (Sf‐9) insect cell system, compromising the labeling of the protein with fluorescent probes for biochemical studies. Therefore, we produced N‐terminal deletion mutants lacking the N‐terminal cysteine (ΔC2). The ΔC2 wild‐type construct behaved similar to porcine cardiac α‐actin purified from native Sus scrofa heart tissue and all ΔC2 constructs showed improved fluorescent labeling. Further analysis of untruncated and ΔC2 constructs showed that while neither the A21V nor the D26N mutation affects nucleotide binding, they cause a similar slowing of the rate of filament formation as well as a reduction in the thermal stability of monomeric and filamentous cardiac α‐actin. In vitro motility assays and transient‐kinetic studies probing the interaction of the actin variants with cardiac β‐myosin revealed perturbed actomyosin interactions and a reduced motile activity for the p.D26N variant. Addition of the small molecule effector EMD 57033, which targets cardiac β‐myosin, rescued the approximately 40% drop in velocity observed with the p.D26N constructs and activated the motile activity of wild‐type and p.D26N to the same level of 1100 nm s−1.