bluuebunny/crossref_metadata_2025_split huggingface dataset:
The multifunctionCoxiellaeffector Vice stimulates macropinocytosis and interferes with the ESCRT machinery
Authors: Bienvenu Arthur , Burette Melanie , Cantet Franck , Gourdelier Manon , Swain Jitendriya , Cazevieille Chantal , Clemente Tatiana , Sadi Arif , Dupont Claire , Fe Manon Le , Bonetto Nicolas , Bordignon Benoit , Muriaux Delphine , Gilk Stacey , Bonazzi Matteo , Martinez Eric 
Published: March 2024

AbstractIntracellular bacterial pathogens divert multiple cellular pathways to establish their niche and persist inside their host.Coxiella burnetii, the causative agent of Q fever, secretes bacterial effector proteins via its Type 4 secretion system to generate aCoxiella-containing vacuole (CCV). Manipulation of lipid and protein trafficking by these effectors is essential for bacterial replication and virulence. Here, we have characterized the lipid composition of CCVs and discovered that the effector Vice interacts with phosphoinositides and membranes enriched in phosphatidylserine (PS) and lysobisphosphatidic acid (LBPA). Remarkably, eukaryotic cells ectopically expressing Vice present compartments that resemble early CCVs in both morphology and composition. We discovered that the biogenesis of these compartments relies on the double function of Vice. The effector protein initially localizes at the plasma membrane of eukaryotic cells where it triggers the internalization of large vacuoles by macropinocytosis. Then, Vice stabilizes these compartments by perturbing the ESCRT machinery and inhibiting the formation of intraluminal vesicles (ILVs). Collectively, our results reveal that Vice is an essentialC. burnetiieffector protein capable of hijacking two major cellular pathways to shape the bacterial replicative niche.Significance statementCoxiella burnetiiis a unique bacterial pathogen that secretes more than a hundred effector proteins to manipulate cellular processes and establish a replicative niche, theCoxiella-containing vacuole (CCV). Our study identified host cell lipids that are actively recruited by the bacterium to the CCV. Using a library of effector mutants, we identified the protein Vice (for Vacuole-inducingCoxiellaeffector) as the first bacterial effector capable of interacting with lysobisphosphatydic acid-enriched membranes and accumulating this lipid to CCVs. We show that Vice is also capable of stimulating macropinocytosis and inhibiting the ESCRT machinery. Together, our data show how a single bacterial effector can manipulate different cellular processes to favor the biogenesis of a bacterial pathogen’s niche.
A biological model of nonlinear dimensionality reduction
Authors: Yoshida Kensuke , Toyoizumi Taro 
Published: March 2024

AbstractObtaining appropriate low-dimensional representations from high-dimensional sensory inputs in an unsupervised manner is essential for straightforward downstream processing. Although nonlinear dimensionality reduction methods such as t-distributed stochastic neighbor embedding (t-SNE) have been developed, their implementation in simple biological circuits remains unclear. Here, we develop a biologically plausible dimensionality reduction algorithm compatible with t-SNE, which utilizes a simple three-layer feedforward network mimicking the Drosophila olfactory circuit. The proposed learning rule, described as three-factor Hebbian plasticity, is effective for datasets such as entangled rings and MNIST, comparable to t-SNE. We further show that the algorithm could be working in olfactory circuits in Drosophila by analyzing the multiple experimental data in previous studies. We finally suggest that the algorithm is also beneficial for association learning between inputs and rewards, allowing the generalization of these associations to other inputs not yet associated with rewards.
De novoevolution of transmissible tumors in Hydra
Authors: Tissot Sophie , Meliani Jordan , Boutry Justine , Brazier Lionel , Tökölyi Jácint , Roche Benjamin , Ujvari Beata , Nedelcu Aurora M. , Thomas Frédéric , Dujon Antoine M. 
Published: March 2024

AbstractWhile most cancers are not transmissible, there are rare cases where cancer cells have acquired the ability to spread vertically or horizontally to other individuals, and sometimes species, causing epidemics in their hosts. However, as these transmissible cancers are usually detected once they are relatively well disseminated in host populations, the conditions associated with their origin remain poorly understood. Using the freshwater cnidarianHydra oligactis, which exhibits spontaneous tumor development that in some strains became vertically transmitted, this study presents the first experimental observation of the evolution of a transmissible tumor. Specifically, we assessed the initial vertical transmission rate of spontaneous tumors and explored the potential for optimizing this rate through artificial selection. One of the hydra strains, which evolved transmissible tumors over five generations, was characterized by analysis of cell type and microbiome, as well as assessment of life-history traits. Our findings indicate that tumor transmission can be immediate for some strains and can be enhanced by selection. The resulting tumors are characterized by overproliferation of large interstitial stem cells and, in contrast with other transmissible tumors on Hydra, are not associated with a specific microbiome. Furthermore, although tumor transmission has only been established over 5 generations, it was sufficient to alter life-history traits in the host, suggesting a compensatory response. This work, therefore, makes the first contribution to understanding the conditions of transmissible cancer emergence and their short-term consequences for the host.
Maglev for dark matter: Dark-photon and axion dark matter sensing with levitated superconductors
Authors: Higgins Gerard , Kalia Saarik , Liu Zhen 
Published: March 2024

Ultraprecise mechanical sensors offer an exciting avenue for testing new physics. While many of these sensors are tailored to detect inertial forces, magnetically levitated (Maglev) systems are particularly interesting, in that they are also sensitive to electromagnetic forces. In this work, we propose the use of magnetically levitated superconductors to detect dark-photon and axion dark matter through their couplings to electromagnetism. Several existing laboratory experiments search for these dark-matter candidates at high frequencies, but few are sensitive to frequencies below 1 kHz (corresponding to dark-matter masses mDM≲10−12  eV). As a mechanical resonator, magnetically levitated superconductors are sensitive to lower frequencies, and so can probe parameter space currently unexplored by laboratory experiments. Dark-photon and axion dark matter can source an oscillating magnetic field that drives the motion of a magnetically levitated superconductor. This motion is resonantly enhanced when the dark matter Compton frequency matches the levitated superconductor’s trapping frequency. We outline the necessary modifications to make magnetically levitated superconductors sensitive to dark matter, including specifications for both broadband and resonant schemes. We show that in the Hz≲fDM≲kHz frequency range our technique can achieve the leading sensitivity among laboratory probes of both dark-photon and axion dark matter.

Published by the American Physical Society
2024
Spin-Orbit Excitons in a Correlated Metal: Raman Scattering Study of
Sr2RhO4
Authors: Wang Lichen , Liu Huimei , Zimmermann Valentin , Yogi Arvind Kumar , Isobe Masahiko , Minola Matteo , Hepting Matthias , Khaliullin Giniyat , Keimer Bernhard 
Published: March 2024

Using Raman spectroscopy to study the correlated 4d-electron metal Sr2RhO4, we observe pronounced excitations at 220 meV and 240 meV with A1g and B1g symmetries, respectively. We identify them as transitions between the spin-orbit multiplets of the Rh ions, in close analogy to the spin-orbit excitons in the Mott insulators Sr2IrO4 and α−RuCl3. This observation provides direct evidence for the unquenched spin-orbit coupling in Sr2RhO4. A quantitative analysis of the data reveals that the tetragonal crystal field Δ in Sr2RhO4 has a sign opposite to that in insulating Sr2IrO4, which enhances the planar xy orbital character of the effective J=1/2 wave function. This supports a metallic ground state, and suggests that c-axis compression of Sr2RhO4 may transform it into a quasi-two-dimensional antiferromagnetic insulator.

Published by the American Physical Society
2024
Emotions, empathy and social justice education
Authors: Smagorinsky Peter 
Published: March 2024

Purpose
This study aims to consider the role of emotions, especially those related to empathy, in promoting a more humane education that enables students to reach out across kinship chasms to promote the development of communities predicated on a shared value on mutual respect. This attention to empathy includes a review of the rational basis for much schooling, introduces skepticism about the façade of rational thinking, reviews the emotionally flat character of classrooms, attends to the emotional dimensions of literacy education, argues on behalf of taking emotions into account in developmental theories and links empathic connections with social justice efforts. The study’s main thrust is that empathy is a key emotional quality that does not come naturally or easily to many, yet is important to cultivate if social justice is a goal of education.

Design/methodology/approach
The author clicked Essay and Conceptual Paper. Yet the author required to write the research design.

Findings
The author clicked Essay and Conceptual Paper. Yet the author required to write the research design.

Research limitations/implications
The author clicked Essay and Conceptual Paper. Yet the author required to write the research design.

Originality/value
The paper challenges the rational emphasis of schooling and argues for more attention to the ways in which emotions shape thinking.
A review on textile-based humidity sensors for wearable physical monitoring
Authors: Baysal Gülçin 
Published: March 2024

PurposeThe aim of this review is to present together the studies on textile-based moisture sensors developed using innovative technologies in recent years.Design/methodology/approachThe integration levels of the sensors studied with the textile materials are changing. Some research teams have used a combination of printing and textile technologies to produce sensors, while a group of researchers have used traditional technologies such as weaving and embroidery. Others have taken advantage of new technologies such as electro-spinning, polymerization and other techniques. In this way, they tried to combine the good working efficiency of the sensors and the flexibility of the textile. All these approaches are presented in this article.FindingsThe presentation of the latest technologies used to develop textile sensors together will give researchers an idea about new studies that can be done on highly sensitive and efficient textile-based moisture sensor systems.Originality/valueIn this paper humidity sensors have been explained in terms of measuring principle as capacitive and resistive. Then, studies conducted in the last 20 years on the textile-based humidity sensors have been presented in detail. This is a comprehensive review study that presents the latest developments together in this area for researchers.
Institutional quality, FDI inflows, human capital development and poverty: a case of Indonesia
Authors: Goh Lim Thye , Trinugroho Irwan , Law Siong Hook , Rusdi Dedi 
Published: March 2024

PurposeThe objective of this paper is to investigate the impact of institutional quality, foreign direct investment (FDI) inflows and human capital development on Indonesia’s poverty rate.Design/methodology/approachThe quantile regression on data ranging from 1984 to 2019 was used to capture the relationship between the impact of the independent variables (FDI inflows, institutional quality and human capital development) on Indonesia’s poverty rate at different quantiles of the conditional distribution.FindingsThe empirical results reveal that low-quantile institutional quality is detrimental to poverty eradication, whereas FDI inflows and human capital development are significant at higher quantiles of distribution. This implies that higher-value FDI and advanced human capital development are critical to lifting Indonesians out of poverty.Practical implicationsPolicymakers should prioritise strategies that advance human capital development, create an enticing investment climate that attracts high-value investments and improve institutional quality levels.Originality/valueThis study contributes to the existing literature because, compared to previous studies that focussed on estimating the conditional mean of the explanatory variable on the poverty rate. It rather provides a more comprehensive understanding of the quantiles of interest of FDI inflows and institutional quality on the Indonesian poverty rate, allowing for more targeted policies.Peer reviewThe peer review history for this article is available at: https://publons.com/publon/10.1108/IJSE-09-2023-0733
Research data management practices of faculty members in Ghanaian universities
Authors: Arthur Beatrice , van der Walt Thomas 
Published: March 2024

PurposeThe purpose of this study is to investigate the current research data management practices among researchers in Ghana and their impact on data reuse and collaborative research. The study aims to identify the methods used by researchers to store and preserve their research data, as well as to determine the extent to which researchers share their data with others.Design/methodology/approachThe study uses a mixed-method research strategy to blend qualitative and quantitative data and is conducted at two public and two private universities in Ghana.FindingsThe study revealed that researchers in Ghana currently store and preserve their research data using personal devices, such as laptops, CDs and external flash drives, rather than keeping the data in university data repositories. They also do not share their research data with others, which negatively affects collaborative research. The current practice of storing data on personal devices and not sharing data with others hinders collaborative research. The study recommends that universities in Ghana revise their research policy documents to address RDM-related issues such as data storage, data preservation, data sharing and data reuse.Research limitations/implicationsThe study was conducted at two public and two private universities in Ghana, but the findings were placed in a wider context through appropriate references.Practical implicationsThis study emphasises the need for sound research data management procedures to support research collaboration and data reuse in Ghana. Universities should provide incentives to academics to disclose their data to encourage data sharing and collaboration.Social implicationsThe government and management of universities should consciously invest in the needed technologies and equipment to implement research data management in their universities.Originality/valueThis study looks at how researchers in Ghana manage their research data and how it affects data reuse and collaborative research.
From bonus to burden: The cost of ruling from a new(s) perspective
Authors: THESEN GUNNAR , GREEN‐PEDERSEN CHRISTOFFER , MORTENSEN PETER 
Published: March 2024

AbstractStudies have repeatedly documented the cost of ruling: governing parties generally suffer electoral defeats. We approach this empirical law of political science from the perspective of another empirical law: the incumbency bonus, the fact that incumbents get more media attention than the opposition. Our claim is that the bonus constitutes an electoral liability because it reflects the critical approach of media to government power. News featuring incumbents is therefore associated with a more negative tone than news featuring the opposition. This incumbency burden in turn affects government support negatively. Empirically, we draw on an extensive news corpus covering four European countries over two decades, combined with monthly poll data. Analyses show that the incumbency burden in political news is an empirical reality, and that variations in the burden contribute substantially to predictions of government support. Finally, the negative burden effect is stronger for single‐party cabinets, but stable throughout government tenure.
Long noncoding RNA LRG modulates Drosophila locomotion by sequestering Synaptotagmin 1 protein
Authors: Cui Ming‐Yang , Xu Meng‐Bo , Wang Ying‐Xuan , Bai Bao‐Yan , Chen Run‐Sheng , Liu Li , Li Mei‐Xia 
Published: March 2024

AbstractApparently, the genomes of many organisms are pervasively transcribed, and long noncoding RNAs (lncRNAs) make up the majority of cellular transcripts. LncRNAs have been reported to play important roles in many biological processes; however, their effects on locomotion are poorly understood. Here, we presented a novel lncRNA, Locomotion Regulatory Gene (LRG), which participates in locomotion by sequestering Synaptotagmin 1 (SYT1). LRG deficiency resulted in higher locomotion speed which could be rescued by pan‐neuronal overexpression but not by limited ellipsoid body, motoneuron or muscle‐expression of LRG. At the molecular level, the synaptic vesicles (SVs) release and movement‐related SYT1 protein was recognized as LRG‐interacting protein candidate. Furthermore, LRG had no effects on SYT1 expression. Genetically, the behavioral defects in LRG mutant could be rescued by pan‐neuronal knock‐down of Syt1. Taken together, all the results suggested LRG exerts regulatory effects on locomotion via sequestering SYT1 thereby blocking its function without affecting its expression. Our work displays a new function of lncRNA and provides insights for revealing the pathogenesis of neurological diseases with motor disorders.
Competition, cooperation, and parental effects in larval aggregations formed on carrion by communally breeding beetles Necrodes littoralis (Staphylinidae: Silphinae)
Authors: Lis Natalia , Mądra‐Bielewicz Anna , Wydra Jędrzej , Matuszewski Szymon 
Published: March 2024

AbstractAggregations of juveniles are dominant forms of social life in some insect groups. Larval societies are shaped by competitive and cooperative interactions of the larvae, in parallel with parental effects. Colonies of necrophagous larvae are excellent systems to study these relationships. Necrodes littoralis (Staphylinidae: Silphinae), a carrion beetle that colonizes cadavers of large vertebrates, forms massive juvenile aggregations. By spreading over carrion anal and oral exudates, the beetles form the feeding matrix, in which the heat is produced and by which adults presumably affect the fitness of the larvae. We predict that exploitative competition shapes the behavior of N. littoralis larvae in their aggregations. However, cooperative interactions may also operate in these systems due mainly to the benefits of collective exodigestion. Moreover, indirect parental effects (i.e., formation of the feeding matrix) probably modulate larval interactions within the aggregations. By manipulating parental effects (present/absent) and larval density (0.02−1.9 larvae/g of meat), we found a strong negative group‐size effect on fitness components of N. littoralis, in colonies with parental effects over almost the entire density range, and in colonies without parental effects for densities larger than 0.5 larva/g. This was accompanied by positive group‐size effects in terms of development time (it shortened with larval density) and thermogenesis (it increased with larval density). A pronounced positive group‐size effect on juvenile fitness was found only in colonies without parental effects and only in the low‐density range. These results support the hypothesis that larval societies of N. littoralis are shaped by exploitation competition.
Epistemic competition in global governance: The case of pharmaceutical patents
Authors: Couette Cynthia 
Published: March 2024

AbstractExpert consensus helps policymakers solve complex problems by identifying and legitimizing policy solutions. Yet, persistent hesitation remains among policymakers regarding the technically adequate policy solution despite the existence and mobilization of epistemic communities. This paper contends that more attention should be given to studying the epistemic competition that may arise when multiple epistemic communities grapple with the same problem but have divergent understandings of its technical nature and its adequate policy solutions. Building on Science and Technology Studies and on the literature on polarization, this paper suggests that two social dynamics, namely the mobilization of resources and increased polarization, may complexify the technical disagreement among experts. In turn, these dynamics may lead to a deadlock in the debates, negatively impacting the institutional context where they take place. To illustrate this, this paper analyzes the case of the pharmaceutical innovation system, which has been prone to tensions between experts arguing for strong patent protection and experts arguing for greater flexibility to meet public health needs. This paper builds on a mixed method combining a social network analysis of experts invited to provide their expertise in the WHO‐WTO‐WIPO Trilateral Cooperation events and on semi‐structured interviews with 24 of these experts.
General practitioner prescription patterns for atopic eczema in children—Are they affected by telemedicine advice?
Authors: Ying Geoffrey , Koch Karen 
Published: March 2024

AbstractTraditionally, patients presenting to primary care with severe eczema would be referred to a dermatology clinic for an in‐person specialist appointment. With the rise of teledermatology, dermatologists are instead dispensing tailored written advice based on information provided in the referral. However, there is currently minimal literature assessing whether this advice translates into relevant prescriptions. This clinical audit examines GP prescribing practices and how they correlate to dermatologist recommendations with the objective of assessing whether this form of teledermatology is a viable method of providing care to paediatric eczema patients.
Mechanisms underlying the relations between parents' perfectionistic tendencies and young children's mathematical abilities
Authors: Cheung Sum Kwing , Chan Winnie Wai Lan , Fong Ricci Wai‐tsz 
Published: March 2024

AbstractBackgroundParents' high academic expectations are positively associated with young children's mathematical abilities. However, minimal attention has been devoted to whether, and how, different ways of conveying the performance targets would result in different outcomes.AimsThe current study investigated whether and how parents' perfectionistic strivings and concerns were associated with young children's mathematical abilities through home mathematical activities, children's approach motivation to learn mathematics, and children's avoidance motivation to learn mathematics.SampleParticipants included 211 kindergarteners in Hong Kong and their parents.MethodsData were collected through individual child tests and parent questionnaires.ResultsStructural equation modelling revealed that parents' perfectionistic strivings had a direct positive link with children's mathematical abilities, an indirect link via approach motivation to learn mathematics, and an indirect link via home mathematical activities, and then approach motivation. Parents' perfectionistic concerns had a direct negative link with children's mathematical abilities, an indirect link via approach motivation to learn mathematics, and an indirect link via avoidance motivation to learn mathematics.ConclusionsEarly childhood practitioners are recommended to raise parents' awareness of how to communicate high‐performance targets to children in a constructive manner.