bluuebunny/crossref_metadata_2025_split huggingface dataset:
CD133 ligand‐enhanced etoposide‐liposome complex for targeted killing of lung cancer cells
Authors: Nie Shiwei , Zhou Junzheng , Zheng Xiaodong , Wei Xudong , Zhang Jinrui , Shen Xiaojuan , Zhang Weimin 
Published: April 2024

AbstractLung cancer has a high incidence rate and a low cure rate, hence the urgent need for effective treatment methods. Current lung cancer drugs have several drawbacks, including low specificity, poor targeting, drug resistance, and irreversible damage to normal tissues. Therefore, there is a need to develop a safe and effective new drug that can target and kill tumor cells. In this study, we combined nanotechnology and biotechnology to develop a CD133 ligand‐modified etoposide‐liposome complex (Lipo@ETP‐CD133) for targeted therapy of lung cancer. The CD133 ligand targeted lung cancer stem cells, causing the composite material to aggregate at the tumor site, where high levels of ETP liposomes could exert a strong tumor‐killing effect. Our research results demonstrated that this nano‐drug had efficient targeting and tumor‐killing effects, indicating its potential for clinical application.
TA2Viewer: A web‐based browser for Terminologia Anatomica and online anatomical knowledge
Authors: Halle Michael W. , Kikinis Ron , Neumann Paul E. 
Published: April 2024

AbstractTA2Viewer is an open‐access, web‐based application and database for browsing anatomical terms and associated medical information on a computer or mobile device (https://ta2viewer.openanatomy.org/). It incorporates the official digital version of the second edition of Terminologia Anatomica (TA2) as published by the Federative International Programme for Anatomical Terminology (FIPAT), and adopted by the International Federation of Associations of Anatomists (IFAA) and other associations. It provides a dynamic and interactive view of the Latin and English nomenclatures. The organizational hierarchy of the terminology can be navigated by using a scrollable, expandable, and collapsible structured listing. Interactive search includes the official TA2 terms, synonyms, and related terms. TA2Viewer also uses TA2 term information to provide convenient access to other online resources, including Google web and image searches, PubMed, and Radiopaedia. Using cross‐references from Wikidata, which were provided by the Wikipedia community, TA2Viewer offers links to Wikipedia, UBERON, UMLS, FMA, MeSH, NeuroNames, the public domain 20th edition of Gray's Anatomy, and other data sources. In addition, it can optionally use unofficial synonyms from Wikidata to provide multilingual term searches in hundreds of languages. By leveraging TA2, TA2Viewer provides free access to a curated anatomical nomenclature and serves as an index of online anatomical knowledge.
A real‐world retrospective–prospective analysis of efficacy and safety of combined ixazomib, lenalidomide, and dexamethasone in relapsed/refractory multiple myeloma: The northern Italy experience
Authors: Furlan Anna , Cea Michele , Pavan Laura , Galli Monica , Clissa Cristina , Mangiacavalli Silvia , Cafro Anna Maria , Girlanda Stefania , Patriarca Francesca , Minotto Claudia , Bertoldero Giovanni , Barilà Gregorio , Pascarella Anna , Lico Albana , Paolini Rossella , Rabassi Nicholas , Pescosta Norbert , Porrazzo Marika , De Sabbata Giovanni , Pompa Alessandra , Bega Giulia , Cavallin Stefania , Guidotti Francesca , Marcatti Magda , Rupolo Maurizio , Belotti Angelo , Gherlinzoni Filippo , Zambello Renato 
Published: April 2024

AbstractIntroductionIxazomib, lenalidomide, and dexamethasone (IRd) have been approved for the treatment of relapsed/refractory multiple myeloma (RRMM) based on the results of the TOURMALINE‐MM1.Objectives and MethodsWe conducted a retrospective–prospective analysis of 106 RRMM patients (pts) treated with IRd in 21 centers in Northern Italy, with the aim to evaluate the efficacy and safety of IRd in real life.ResultsAt IRd initiation, 34% of pts were aged ≥75 (median 72.5), 8.5% had an ECOG performance status ≥2, 54.7% of evaluable pts carried high‐risk cytogenetic abnormalities [del17p and/or t(4;14) and/or t(14;16) and/or 1 g gain/amp], 60.2% had received ≥2 prior lines of therapy (pLoT), 57.5% were lenalidomide (Len)‐exposed (including both Len‐sensitive and Len‐refractory pts), and 22% were Len‐refractory. Main G ≥3 adverse events (AEs) were thrombocytopenia (16%) and neutropenia (12.3%). G ≥3 non‐hematologic AEs included infections (9.4%) and GI toxicity (diarrhea 5.7%, hepatotoxicity 2.8%), VTE, skin rash, and peripheral neuropathy were mainly G1‐2. The overall response rate was 56.4% (≥VGPR 30%). With a median follow‐up of 38 m, median PFS (mPFS) was 16 m and the 1‐year OS rate was 73%. By subgroup analysis, an extended PFS was observed for pts achieving ≥VGPR (mPFS 21.2 m), time from diagnosis to IRd ≥5 years (26.2 m), 1 pLoT (34.4 m), Len‐naïve (NR), age ≥70 (20 m). In pts exposed to Len, non‐refractory in any prior line and immediately prior to IRd, mPFS was 16 and 18 m, respectively. An inferior PFS was seen in Len‐refractory pts (4.6 m). By multivariate analysis, independent predictors of PFS were age ≥70 (HR 0.6), time from diagnosis ≥5 years (HR 0.32), refractoriness to Len in any prior line (HR 3.33), and immediately prior (HR 4.31).ConclusionIRd might be effective and safe in RRMM pts with an indolent disease, in early lines of treatment, and who proved Len‐sensitive, independent of age, and cytogenetic risk.
Gendered capital in psychotherapy: A thematic analysis of patients' experiences of the therapists' gender
Authors: Schweitzer Erwin , Schaffler Yvonne , Jesser Andrea , Probst Thomas , Humer Elke , Schigl Brigitte 
Published: April 2024

AbstractBackgroundThe impact of therapists' and patients' gender on therapy processes and outcomes remains a subject of intense debate in psychotherapy research.AimsThis article explores the role of gender in psychotherapy from the patients' perspective.MethodBy conducting semi‐structured interviews with 20 patients undergoing individual psychotherapy in private practices in Austria, the influence of the therapist's gender was investigated. The data collected were subjected to qualitative thematic analysis.FindingsThe authors adopted a Bourdieusian feminist perspective to interpret the results, revealing that patients perceived female psychotherapists as possessing unique resources not found in male therapists. These resources encompassed knowledge, skills, traits perceived as ‘female’, and shared body and life experiences. Referred to as ‘female gender capital’, these resources influenced the preferences of most female and one male patient, leading them to favour female psychotherapists.ConclusionGiven the strong perceptions and preferences around gender observed in this study, gender identity and gendered practices should be critically reflected on by individual therapists as well as in psychotherapy training programmes.
Exploration of Some Heterocyclic Compounds Containing Trifluoromethylpyridine Scaffold as Insecticides Toward Aphis gossypii Insects
Authors: Gad Mohamed A. , Bakry Moustafa M. S. , Tolba Eman F. M. , Alkhaibari Abeer M. , Mashlawi Abadi M. , Thabet Marwa A. , Al‐Taifi Elham A. , Bakhite Etify A. 
Published: April 2024

AbstractFive types of heterocyclic compounds containing trifloromethylpyridine scaffold namely; 3‐cyano‐2‐(N‐phenyl)carbamoylmethylthio‐6‐(thiophen‐2‐yl)‐4‐trifluoromethyl‐pyridine (6a), thieno[2,3‐b]pyridines 3–5 and 7a–c, pyrido[3′,2′:4,5]thieno[3,2‐d] pyrimidines 8–13 and 15a–c, pyrido[3′,2′:4,5]thieno[3,2‐d][1,2,3]triazines 16a,b, and 9‐(thiophen‐2‐yl)‐7‐(trifluoromethyl) pyrido [3′,2′:4,5]thieno[2,3‐e][1,2,4]triazolo[1,5‐c]pyrimidine (14) were synthesized in excellent yields and very pure state. The structures of these compounds were confirmed by elemental and spectral analyses. Most of the synthesized compounds were evaluated as insecticidal agents toward Aphis gossypii insects and promising results obtained. Among all tested compounds, only 6, 7a, 7c and 15c being the most potent compounds against nymphs and adults of Aphis gossypii and their activities are nearly to that of acetamiprid as a reference. The effect of 6a compounds 7a, 7c and 15c on the Aphis digestive system from histological point of view was also included.
Epidermoid cyst of the testis: A report of three cases
Authors: Usui Kimitsugu , Yamashita Ryo , Sakura Yuma , Nakamura Masafumi , Shinsaka Hideo , Matsuzaki Masato , Niwakawa Masashi 
Published: April 2024

Key Clinical MessageTesticular epidermoid cysts have characteristic findings. Testicular tumor markers are negative in patients with epidermoid cysts. Clear margins and sole and small testicular tumors (20 mm or less) suggest the possibility of epidermoid cyst. Testicular‐sparing surgery with intraoperative frozen section examination should be performed when suspecting epidermoid cysts. Testicular epidermoid cysts are rare tumors that account for 1% of all testicular tumors and are often clinically misdiagnosed as malignant lesions. We report three cases of epidermoid cysts. The chief manifestations were scrotal induration in two patients and pruritus scrotum in one. The median age of the patients was 23 years (18–30). All tumors were determined to be sole lesions (<20 mm in diameter). Testing for tumor markers in all patients revealed negative results. We could not rule out malignancy; hence, we performed high inguinal orchiectomy in all cases. Histologically, the inner walls of the cysts were lined with stratified squamous epithelium; their contents were keratinized. All patients were diagnosed with epidermoid cysts.
Extrapulmonary tuberculosis presenting as hemorrhagic pleuro‐pericardial effusions with pericardial mass
Authors: Abdelghani Mohammad S. , Chapra Ammar , Al‐Qudah Bara , Bishawi Ahmed , Shebani Ahmed , Obeidat Ibrahim , Habib Mhd Baraa 
Published: April 2024

Key Clinical MessageTuberculosis (TB) pericarditis, while uncommon, should be considered in patients with pericardial masses and effusion. Timely recognition and treatment with anti‐TB medications are crucial for a successful outcome.AbstractTB pericarditis presenting as a pericardial mass is an unusual and rare manifestation of this disease. We report a 59‐year‐old South Asian male who presented with a 1‐week history of dyspnea and cough. He was found to have a hemorrhagic pericardial mass with a massive pericardial effusion. Pleural fluid analysis was positive for TB. The patient was successfully treated with anti‐TB medications. Although rare, tuberculous pericardial involvement should be suspected in patients presenting with symptoms of pericardial masses and effusion.
Adult colorectal intussusception caused by giant lipoma—A case report
Authors: Heng Vouchly , Oh Suk‐Kyu , Leng Hour , Chhun Vireak , Lee Young Don 
Published: April 2024

Key Clinical MessageAdult intussusception commonly has a leading point. In the colon, malignancy is a prevalent etiology for the leading point; however, benign tumors should also be considered. We present a case of colorectal intussusception caused by a giant lipoma.AbstractIntussusception in adults is comparatively infrequent in contrast to children, and in adult colonic intussusception, malignancy is the predominant cause of the leading point. Lipoma, an uncommon tumor in the gastrointestinal tract, rarely induces colonic intussusception in adults. We present the case of a 55‐year‐old Cambodian man experiencing cramping abdominal pain. He presented with mild abdominal distension with tenderness in the lower abdomen. On the rectal examination a large palpable mass was detected three to four centimeters from the anal verge. Abdominal computerized tomography revealed a collapsed sigmoid colon with mesenteric fat invaginated into the lumen of the upper rectum. Emergency laparotomy was performed and during the surgery the sigmoid intussusception spontaneously reduced. A mass was identified in the mid‐sigmoid colon, leading to the decision for segmental resection of the sigmoid colon with the mass and subsequent end‐to‐end anastomosis. Histological examination results confirmed the mass as a lipoma. Colorectal intussusception in adults due to a lipoma is a relatively rare, with only a few reported cases in the literature.
NiFe Catalysts for Oxygen Evolution Reaction: Is There an Optimal Thickness for Generating a Dynamically Stable Active Interface?
Authors: Ciambriello Luca , Alessandri Ivano , Gavioli Luca , Vassalini Irene 
Published: April 2024

AbstractHere we investigated the dynamics of OER activity of NiFe (90/10) catalysts over 1000 potential sweep cycles as a function of their mass loading. Over twenty different films with mass loading in the 10 ng/cm2–30 μg/cm2 range were deposited by Supersonic Cluster Beam Deposition (SCBD), allowing to study the progress of OER in sub‐monolayer, monolayer and multilayer regimes. Upon prolonged potential sweeps the electrocatalytic performances of multilayers decreased, while those of monolayers were significantly improved. The best balance in terms of catalytic efficiency and stability in working conditions is found for mass loadings corresponding to a NiFe monolayer, corresponding to a mass loading around 1 μg/cm2 and a thickness of about 3 nm.
Fluid Flow Study in a 3D‐Printed Heterogeneous Porous Medium Filled with Carbonate Rock Particles
Authors: Sapucaia da Silva Junior Elivaldo , Fontana Eliton , de Lima Luz Junior Luiz Fernando 
Published: April 2024

AbstractA significant aspect of fluid flow in a porous medium is its properties' variation which affects velocity and pressure fields. This work evaluates fluid flow in a 3D‐printed porous medium structure filled with rocky particles. The experimental data were used to propose a pressure drop model and evaluate the accuracy of a pseudohomogeneous approximation. A porous medium with permeability of 8.95 × 10−10 m2 was used in both experiments and simulations. Parameters for the model were estimated and compared to the simulation results. The deviation between experimental and simulated pressure drop across the bed was within 6.00 % for laminar flow regimes, while for transition flow regimes more significant deviations were observed.
On the Impact of Non‐CHO Elements on Fuel Properties in Waste Incineration
Authors: Förtsch Dieter 
Published: April 2024

AbstractIncineration is and will remain a proven technology for the safe and sustainable destruction of environmentally hazardous substances. The behavior of non‐CHO elements during combustion plays an important role in the design of incinerators for hazardous waste since they drive the selection and design of the process sequence and of the single equipment. This contribution presents an overview on impacts of the presence of non‐CHO compounds in waste incinerators and provides correlations to estimate the product distribution of sulfur‐ and halogen‐containing compounds as well as for the important fuel properties oxygen demand and heat of combustion of material containing non‐CHO elements.
Multi‐Scale Simulation of a Novel Integrated Reactor for Hydrogen Production by Ammonia Decomposition
Authors: Blauth Sebastian , Damay Julie , Osterroth Sebastian , Leithäuser Christian , Hofmann Christian , Kolb Gunther , Wichert Martin , Steiner Konrad , Bortz Michael 
Published: April 2024

AbstractA novel reactor concept for ammonia decomposition utilizing tail gas from a purification unit as heat supply is presented. The designed micro‐structured reactor integrates both endothermic ammonia decomposition and exothermic tail gas combustion. The reactor and corresponding process are simulated using a mathematical multi‐scale model, which combines the results of multiple detailed computational fluid dynamics simulations into a fast surrogate model. The latter is coupled with a process simulation software via a so‐called container to simulate the entire process. The efficiency of the presented reactor concept is determined and benefits over alternative approaches are highlighted.
Comparison of the Prediction of the Temperature Profile in an Ohmic Reactor on Different Modeling Scales
Authors: Geitner Christian , Iliev Oleg , Matschuk Kimberley , Menne Andreas , Nakos Philippos , Osterroth Sebastian , Peters Martin , Steiner Konrad , Zausch Jochen 
Published: April 2024

AbstractTo predict the temperature profile in an ohmic reactor, it is essential to know the thermal and electrical conductivity of the reactor geometry. Those properties can be considered on different modeling scales: On the detailed (resolved) scale, the reactor consists of a packed bed structure, where the properties of each substance are considered. On the effective (continuum) scale, the packed bed is considered as effective medium with composite properties. In this contribution, we consider both scales and compare the results. Based on the detailed description with a resolved microstructure, the bed's effective thermal and electrical conductivity are computed. These properties are compared with analytical formulas. The electrical conductivity is the basis for the electrical field and the current density. Finally, these properties are used to evaluate the ohmic heating of the packed bed exposed to flow and to compute the temperature distribution within the reactor.
Prediabetes and major adverse cardiac events after acute coronary syndrome: An overestimated concept
Authors: Behnoush Amir Hossein , Maleki Saba , Arzhangzadeh Alireza , Khalaji Amirmohammad , Pezeshki Parmida Sadat , Vaziri Zahra , Esmaeili Zahra , Ebrahimi Pouya , Ashraf Haleh , Masoudkabir Farzad , Vasheghani‐Farahani Ali , Hosseini Kaveh , Mehrani Mehdi , Hernandez Adrian V. 
Published: April 2024

AbstractBackgroundUnlike diabetes, the effect of prediabetes on outcomes in patients with acute coronary syndrome (ACS) who underwent percutaneous coronary intervention (PCI) is not much investigated. We investigated the association between fasting glycemic status and major adverse cardiovascular and cerebrovascular events (MACCE) in patients with ACS undergoing PCI and had mid to long‐term follow‐up after coronary stenting.MethodsRegistry‐based retrospective cohort study included ACS patients who underwent PCI at the Tehran Heart Center from 2015 to 2021 with a median follow‐up of 378 days. Patients were allocated into normoglycemic, prediabetic, and diabetic groups. The primary and secondary outcomes were MACCE and its components, respectively. Unadjusted and adjusted Cox models were used to evaluate the association between glycemic status and outcomes.ResultsAmong 13 682 patients, 3151 (23%) were prediabetic, and 5834 (42.6%) were diabetic. MACCE risk was significantly higher for diabetic versus normoglycemic (adjusted hazard ratio [aHR]: 1.22, 95% confidence interval [CI]: 1.06–1.41), but nonsignificantly higher for prediabetic versus normoglycemic (aHR: 0.95, 95% CI: 0.78–1.10). All‐cause mortality risk was significantly higher in diabetic versus normoglycemic (aHR: 1.42, 95% CI: 1.08–1.86), but nonsignificantly higher for prediabetic versus normoglycemic (aHR: 1.15, 95% CI: 0.84–1.59). Among other components of MACCE, only coronary artery bypass grafting was significantly higher in diabetic patients, and not prediabetic, compared with normoglycemic.ConclusionsPrediabetic ACS patients undergoing PCI, unlike diabetics, are not at increased risk of MACCE and all‐cause mortality. While prediabetic patients could be regarded as having the same risk as nondiabetics, careful consideration to provide more intensive pre‐ and post‐PCI care in diabetic patients is mandatory.
On the utilization of the adjoint method in microwave tomography
Authors: Soydan Damla Alptekin , Top Can Barış , Gençer Nevzat G. 
Published: April 2024

AbstractIn microwave imaging, the adjoint method is widely used for the efficient calculation of the update direction, which is then used to update the unknown model parameter. However, the utilization and the formulation of the adjoint method differ significantly depending on the imaging scenario and the applied optimization algorithm. Because of the problem‐specific nature of the adjoint formulations, the dissimilarities between the adjoint calculations may be overlooked. Here, we have classified the adjoint method formulations into two groups: the direct and indirect methods. The direct method involves calculating the derivative of the cost function, whereas, in the indirect method, the derivative of the predicted data is calculated. In this review, the direct and indirect adjoint methods are presented, compared, and discussed. The formulations are explicitly derived using the two‐dimensional wave equation in frequency and time domains. Finite‐difference time‐domain simulations are conducted to show the different uses of the adjoint methods for both single source‐multiple receiver, and multiple transceiver scenarios. This study demonstrated that an appropriate adjoint method selection is significant to achieve improved computational efficiency for the applied optimization algorithm.
The synergistic effects of green innovation strategies on sustainable innovative performance with the mediation of green innovative competitive advantage
Authors: Hayat Khizar , Qingyu Zhang 
Published: April 2024

AbstractThis study offers valuable insights into the factors underpinning the cultivation of green innovation competitive advantage (GICA) and the stimulation of sustainable innovative firm performance (SIFP). While previous research has predominantly fixated on assessing the financial ramifications of green innovation endeavors, the current discourse of governmental and non‐governmental authorities, has witnessed a surge in discussions surrounding green innovation strategies (GIS) to address climate change. We contend that constructing GICA through innovative products rather than traditional ones poses a formidable challenge. To address this lacuna, our research dissects GIS into three dimensions (i.e., green product, process, and service innovation) to enhance GICA and SIFP. To probe these intricate relationships, we meticulously examined data from 545 Chinese firms, seeking to unravel the complex connections between GIS, GICA, SIFP and moderation of CSR. We constructed a comprehensive model grounded in established theories, resource‐based theory (RBT), and the theory of competitive advantage. Structural equation modeling via SPSS and AMOS was employed to analyze the data rigorously. Our findings unequivocally underscore the pivotal role of GIS in nurturing GICA. As a moderating factor, firms that integrate GIS into their CSR initiatives are strategically positioned to secure a substantial competitive edge. Moreover, the primary impetus for businesses to adopt GIS lies in their pursuit of gaining a competitive edge while concurrently sustaining innovative performance over the long haul. These findings underscore the allure of GIS as an avenue to attain SIFP.
Oxygen‐Deficient FeNbO4‐x In‐Situ Growth in Honey‐Derived N‐Doping Porous Carbon for Overall Water Splitting
Authors: Fu Hongliang , Bai Yongqing , Lian Yue , Hu Yongfeng , Zhao Jing , Zhang Huaihao 
Published: April 2024

AbstractIt is still a great challenge to reasonably design green, low cost, high activity and good stability catalysts for overall water splitting (OWS). Here, we introduce a novel catalyst with ferric niobate (FeNbO4) in‐situ growing in honey‐derived porous carbon of high specific surface area, and its catalytic activity is further enhanced by micro‐regulation (oxygen vacancy and N‐doping). From the experimental results and density functional theory (DFT) calculations, the oxygen vacancy in catalyst FeNbO4‐x@NC regulates the local charge density of active site, thus increasing conductivity and optimizing hydrogen/oxygen species adsorption energy. FeNbO4 in‐situ grows within N‐doping honey‐derived porous carbon, which can enhance active specific surface area exposure, strengthen gaseous substances escape rate, and accelerate electrons/ions transfer and electrolytes diffusion. Moreover, in‐situ Raman also confirms O‐species generation in oxygen evolution reaction (OER). As a result, the catalyst FeNbO4‐x@NC shows good electrochemical performance in OER, HER and OWS.