bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neuroprotective Mechanisms and Metabolomics Analysis of Jiedu Yizhi Formula in Alzheimer's Disease
Authors: Li Yunqiang , Yan Jing , Cui Tingting , Chen Dongxue , Zhu Xiaoting , Wang Jie , Zhang Xinyue , Wang Qi , Feng Lina , Zhang Pengqi , Fang Limei , Li Mingquan 
Published: April 2024

Abstract

Aim of the study：We studied the metabolites in the brain tissue of Alzheimer's Disease (AD) transgenic mice to investigate how Jiedu Yizhi Formula (JDYZF) protects against AD and to validate the scientific basis of the prescription using the "Marrow deficiency and toxin damage" theory.
Materials and methods: The effect of JDYZF treatment on cognitive dysfunction was evaluated using the Morris water maze test in the APP/PS1 transgenic mouse model. Furthermore, the impact of JDYZF on typical AD pathology was assessed through Hematoxylin-eosin staining. Additionally, the protective effect of JDYZF on AD neurons was studied using Nissl staining. Moreover, potential mechanisms of action were analyzed through LC-MS/MS-based untargeted metabolomics of mouse brain tissue.
Results: The administration of JDYZF significantly ameliorated memory deficits and mitigated typical histopathological changes in AD mice. Upon comparison of the differential metabolites between the model control group and the blank control group with those between the JDYZF group and the model control group, 17 endogenous metabolites, including 1-methyluric acid, were found to be significantly different. These differential metabolites were primarily involved in the pathways of caffeine metabolism and glycerophospholipid metabolism.
Conclusion: In this study, we have effectively illustrated the neuroprotective effect of JDYZF on AD through experimentation with the APP/PS1 transgenic mouse model. The findings indicate that the utilization of JDYZF can ameliorate the metabolic disruptions in brain tissue and serve as a viable therapeutic intervention for AD.
Effects of inhalation of the hydrogen-rich gas before sleep on fatigue recovery in healthy adults
Authors: Li Qian , Li Yiting , Liu Haochong , Wang Yubo , Bao Dapeng , Liu Haoyang , Zhou Junhong 
Published: April 2024

Abstract

Our objective was to examine if inhalation of hydrogen-rich gas before sleep can help alleviate fatigue and improve physical performance after waking up in healthy adults. We included 100 healthy adults with no sleep disorders. All participants completed two study visits with a 7-day break. On each of the two, they randomly inhaled either hydrogen-rich (HS) or control gas (CS) for 20 minutes. Each participant completed the assessment of fatigue (e.g., quick recovery, Karolinska Sleepiness scale (KSS)) and functional performance (e.g., Countermovement jump (CMJ), Maximum voluntary isometric contraction (MVIC) and muscle force perception) before inhaling gas and after waking up. No significant difference in the percent change of HRV paraments (i.e., LF/HF, RMSSD, SDNN, LF average, HF average, VLF average) and KSS scale from night to morning were observed between CS and HS (p > 0.67). Similarly, no significant difference in the percent change of CMJ (p = 0.12, Z = 1.55) was observed between CS and HS. Compared to CS, the percent change of MVIC (F = 4.95, p = 0.03, η²=0.03) and muscle force perception (p = 0.01, Z=-2.50) were significantly lower in HS. Inhaling hydrogen-rich gas before sleep can accelerate the recovery of muscle strength and muscle proprioception on the next day in healthy adults.
Self-assembled rectorite films with remarkable mechanical performance: preparation, structural characterization and properties
Authors: Atanasova Maria , Focke Walter W. , Loots Theodor 
Published: April 2024

Abstract

Cohesive flexible rectorite clay films with good mechanical performance were prepared by a simple casting method through self-assembly of exfoliated natural clay from aqueous dispersions. The multi-layered microstructure of the films consisted of continuous layers of aligned clay platelets parallel to the casting surface. Layers overlap randomly in lateral direction (plane) and join vertically in irregular manner by edge to face cross-linkages (bridging) to form coherent multi-layered nanostructured films with platelet-void microstructure. The films with highest mechanical properties had thickness below 30 µm. Overall films from rectorite clay with monovalent interlayer content exibited a higher experimental tensile strengths ranging up to 44 MPa and Young’s modulus up to 56 GPa. The corresponding experimental values for films with divalent interlayer cations were 23 MPa for strength and 25 GPa for modulus. The highest experimental values for strength and modulus for neat Na-Ca-rectorite films were 25 MPa and 50 GPa respectively. The mechanical property values of the rectorite-based clay films compare favourably with values featured by polymer films typically used for packaging applications.
Knockdown of Integrin α3 (ITGA3)-mediated proliferation and invasive activity by regulating the expression of N-cadherin and cyclin D1 in glioblastoma cells
Authors: Fan Wen-Chieh , Tzou Rong-Dar , Lee Kuan-Ting , Huang Tzuu-Yuan , Rau Kun-Ming , Hsu Yi-Chiang , Tsai Tai-Hsin 
Published: April 2024

Abstract

The cell membrane protein Integrin α3 (ITGA3) acts as a crucial cell surface adhesion molecule and has emerged as a potential molecular marker across various cancers. Our study aimed to explore the biological role of ITGA3 in human Glioblastoma (GBM), an area yet to be thoroughly investigated. Initially, we assessed ITGA3 expression in glioma TMA tissue samples through immunohistochemistry analysis. Subsequently, we employed short interfering RNA (siRNA) to silence ITGA3 expression in different GBM cell lines and examined its impact on proliferation, invasion, adhesion, and migration assays. Furthermore, we conducted western blot analyses to gauge the expression levels of ITGA3, N-cadherin, and Cyclin D1 signaling molecules in glioma cells. Our findings revealed a significant correlation between elevated ITGA3 expression and poorer survival rates in patients with astrocytoma and glioma compared to those with low ITGA3 expression. Notably, silencing ITGA3 curbed cell proliferation and hindered cell mobility in glioma, potentially by impeding N-cadherin and Cyclin D1 signaling pathways. Collectively, our results pinpoint ITGA3 as an oncogenic biomarker, with its knockdown showcasing a potential to restrain the metastatic capabilities of GBM cells.
Distributed Hybrid Quantum-Classical Performance Prediction for Hyperparameter Optimization
Authors: Wulff Eric , Amboage Juan Pablo Garcia , Aach Marcel , Gislason Thorsteinn Eli , Ingolfsson Thorsteinn Kristinn , Ingolfsson Tomas Kristinn , Pasetto Edoardo , Delilbasic Amer , Riedel Morris , Sarma Rakesh , Girone Maria , Lintermann Andreas 
Published: April 2024

Abstract

Hyperparameter Optimization of neural networks is a computationally expensive procedure, which requires a large number of different model configurations to be trained. To reduce such costs, this work presents a distributed, hybrid workflow, that runs the training of the neural networks on multiple Graphics Processing Units (GPUs) on a classical supercomputer, while predicting the configurations' performance with Quantum Support Vector Regression on a Quantum Annealer (QA). The workflow is shown to run on up to 50 GPUs and a QA at the same time, completely automating the communication between the classical and the quantum system. The approach is evaluated extensively on several benchmarking datasets from the Computer Vision, High Energy Physics, and Natural Language Processing domains. Results show that resource savings of up to approximately 9% can be achieved while obtaining similar, and in some cases even better, accuracy, highlighting the potential of hybrid quantum-classical machine learning algorithms. The workflow code is made available open-source to foster adoption in the community.
How does entrepreneurial curiosity lead to Chinese undergraduates’ new venture idea: the mediation of promotion focus and the moderation of entrepreneurial education
Authors: Li Caiyun , Hu Rui 
Published: April 2024

Abstract

Background
New venture idea is an “imagined future venture”, it’s more valuable and practical than entrepreneurial opportunity which has been widely studied before for undergraduates’ entrepreneurship. Based on the regulatory focus theory, this study aims to explore how two different types of entrepreneurial curiosity (I-type entrepreneurial curiosity and D-type entrepreneurial curiosity) affect the undergraduates’ new venture idea through promotion focus, as well as the moderating effect of entrepreneurial education.
Methods
With a sample of 650 undergraduates in Chinese universities through questionnaire star platform, this study used a PLS-SEM to test hypotheses.
Results
The results indicated that promotion focus played a full mediating effect between D-type entrepreneurial curiosity and new venture idea, and a partial mediating effect between I-type entrepreneurial curiosity and new venture idea. In addition, entrepreneurial education moderated those mediating effects.
Conclusions
The results highlighted the importance of stimulating undergraduates’ entrepreneurial curiosity so as to form more new venture ideas. Also, it suggested that universities need to improve undergraduates’ promotion focus by optimizing the teaching strategies and contexts of entrepreneurial education, as well as create a good atmosphere of entrepreneurial support.
Effectiveness of Thought Stopping in Treating Obsessive-Compulsive and Compulsive
Authors: Aldahadha Basim , Shdouh Ala , Alnawiseh Mubin 
Published: April 2024

Abstract

The present study aimed to identify the effectiveness of a counseling program based on thought stopping among female students suffering from obsessive-compulsive disorder (OCD) and compulsive hoarding disorder (CHD). The sample consisted of 40 students distributed equally and randomly to the treatment group and waiting list group. OCD and CHD scales and a program based on cognitive behavioral therapy in thought stopping were applied. The results showed that there were significant differences between the treatment and waiting list groups in OCD and CHD in favor of the treatment group on the post measurements. The results also showed the effectiveness of the program in thought stopping on the post measurements and at follow-up a month after program termination. There is the effectiveness of thought-stopping in alleviating the symptoms of OCD and HCD. Attention should be given to early intervention of thought-stopping to reduce CHD by raising awareness of the roles of nurturing and the environment in which this disorder grows and how to prevent it.
Guidance of Hope: The Link of Social Support Influences the Career Educational Response of Senior High School Students
Authors: Ling Hairong , Fang Yanling , Yu Qi , Wu Jing , Song Chunze 
Published: April 2024

Abstract

Background: This research aims to investigate the relationships between social support, hope, career exploration, career adaptability, and reactions to career education among Chinese high school students. The study sample consists of 418 Chinese high school students. Various instruments were utilized to assess the variables, including the Child and Adolescent Social Support Scale, the Hope Scale, the High School Students' Career Exploration Scale, the Career Adapt-Ability Scale-Short Form, and the Reactions to Career Education Scale.
Methods: The study utilized a sample of 418 Chinese high school students to examine the relationships between social support, hope, career exploration, career adaptability, and reactions to career education. The variables were assessed using the instruments. Smart-PLS and SPSS analyses were employed to determine the correlations among the variables.
Results: The analysis revealed a positive correlation between social support, hope, career exploration, career adaptability, and reactions to career education among Chinese high school students. Additionally, evidence suggests that hope, career exploration, and career adaptability act as mediators, indicating the presence of a multi-mediation model.
Conclusions: The findings of this research contribute to the understanding of the relationships between social support, hope, career exploration, career adaptability, and reactions to career education among Chinese high school students. These findings support the development of career education strategies for Chinese senior high schools and provide a basis for assessing the effectiveness of such programs.
Effects of the S1P/S1PR1 signaling pathway on high glucose-induced NRK-52E epithelial- mesenchymal transdifferentiation via regulation of ROS/NLRP3
Authors: Tian Jihua , Chen Jingshu , Sun Qiuyue , Huang Taiping , Xu Huanyu , Wang Jing , Ma Zhijie 
Published: April 2024

Abstract

Diabetic nephropathy (DN) ranks as the predominant complication among diabetics, culminating in renal fibrosis. A variety of processes play a role in its pathophysiology, with the epithelial-mesenchymal transition (EMT) in renal tubular cells being intimately linked to renal fibrosis. Sphingosine 1-phosphate (S1P) functions via G protein-coupled receptors and is involved in multiple signal transmission pathways. Research has demonstrated that the S1P/S1PR pathway controls fibrosis and inflammation. However, the interaction between S1P/S1PR and the pathophysiology of EMT remains ambiguous. The objective of this research was to explore the function of the S1P/S1PR pathway in EMT triggered by high glucose (HG) and how it operates. Employing varied glucose levels for cell treatment, we discovered that HG markedly increased the S1P and EMT marker levels in renal tubular epithelial cells. In vitro, inhibition of S1P1 by FTY720 resulted in a marked decrease in renal tissue EMT. Activation of oxidative stress (OS) can lead to diabetes, with the NLRP3 inflammasome contributing to the inflammation linked to diabetes. Research indicates that blocking reactive oxygen species (ROS) can prevent the NLRP3 inflammasome produced. This investigation examined S1P expression, revealing that blocking S1PR1 led to a reduction in both ROS and NLRP3 inflammasome metrics, it indicates the role of S1P in initiating and advancing HG-induced EMT. The combination of S1P/S1PR1 suppresses HG-induced EMT through the modulation of the ROS/NLRP3 pathway.
Dietary Restriction Promote Sperm Remodeling in Aged Roosters Based on Transcriptome Analysis
Authors: liang wenjie , he yuehua , zhu tingqi , zhang binbin , liu shuangxing , guo haishan , liu pingquan , liu huayuan , liu donghua , kang xiangtao , sun guirong , li wenting 
Published: April 2024

Abstract

Background:
The breeder rooster has played an important role in poultry production by providing high-quality semen. In general, the fertility peaks of breeder roosters between 30 and 40 weeks of age and declines rapidly from 45 to 55 weeks of age. The exploration of improving fertility in aging roosters would help to extend the useful life of roosters. At present, researchers have made some progress, but improving fertility in aging roosters has become an important issue that needs to be addressed.
Methods:
To identify the genes related to promoting sperm remodeling in aged Houdan roosters, we combined changes in testis and semen quality with transcriptome sequencing (RNA-seq) to analyze the synchrony of semen quality and testis development. In this study, 350-day-old Houdan breeder roosters were selected for RNA-seq analysis in testis tissues from induced molting roosters (D group) and non-induced molting roosters (47DG group). All analyses of differentially expressed genes (DEGs) and functional enrichment were performed. Finally, we selected six DEGs to verify the accuracy of the sequencing by qPCR.
Results:
Sperm motility, sperm density, and testis weight were significantly increased in roosters in the fasted-induced molting group compared with the control group (P < 0.05). Further RNA-seq analysis of the testis between the D group and 47DG group identified 61 DEGs, with 21 up-regulated and 40 down-regulated. Functional enrichment analysis showed that the DEGs were primarily enriched in the cytokine-cytokine receptor interaction, Wnt signaling pathway, MAPK signaling pathway, TGF-β signaling pathway, and focal adhesion pathway. The qRT-PCR results showed that the expression trend of these genes was consistent with the sequencing results. WNT5A, FGFR3, AGTR2, TGFβ2, ROMO1, and SLC26A7 may play a role in testis development and spermatogenesis. This study provides fundamental data to enhance the reproductive value of aging roosters.
Comparison of side effects of short-acting inhaled bronchodilators in patients with asthma and chronic obstructive pulmonary disease
Authors: Najeeb Muhammad , AlBardan Housam 
Published: April 2024

Abstract

Background: Excessive use of short-acting inhaled bronchodilators indicates poor asthma control and adverse health outcomes. The research aims to study the side effects of short-acting inhaled bronchodilators in patients with asthma and chronic obstructive pulmonary disease.
Study design:Retrospective, cross-sectional observational study, location. Study: Patients admitted to the Internal Thoracic Division, Damascus Hospital (Al-Mujtahid Hospital), in Damascus, Syria.
Duration of the study: 4 years between 2020 and 2024.
Inclusion criteria: All patients with asthma and obstructive pulmonary disease admitted to the Internal Thoracic Division, Damascus Hospital (Al-Mujtahid Hospital) whose ages range from 18 to 80 years.
Exclusion criteria: Patients with other chronic lung diseases (cancers, tuberculosis), patients taking long-acting bronchodilators, patients taking systemic bronchodilators, patients with cachexia.
Data analysis was performed using SPSS-28 software.
Results: Patients’ ages ranged from 18 to 18 years. -80 years, and the most common age group is 60-80 years, and 61% of patients are male. Headaches, nervous tension, lack of appetite, pharyngeal pain, stomach pain, and muscle spasms were most common among patients treated with short-acting beta-2 analogues, with rates of 82.6% and 75%. 66.6%, 82.6%, and 80%, respectively, while hand tremors, allergic reaction, vomiting, runny nose, agitation, and contractile convulsions were more common in patients treated with short-acting antimuscarinics, with rates of 100%, 66.7%, 100%, 100%, 100%, 100%, respectively.
Conclusion: The use of short-acting bronchodilators was accompanied by a group of side effects, as headache and pharyngeal pain were common in all types, while stomach pain, muscle spasms, nervous tension, and lack of appetite were common in those who used to short-act beta agonists, and allergic reaction, hand tremors, and vomiting. Rhinorrhea, irritability, and constriction were more common among patients using short-acting antimuscarinics, and the occurrence of symptoms was associated with increasing dose and duration of use.
Problems and Barriers Related to the Use of mHealth Apps From the Perspective of Patients: Focus Group and Interview Study
Authors: Giebel Godwin Denk , Abels Carina , Plescher Felix , Speckemeier Christian , Schrader Nils Frederik , Börchers Kirstin , Wasem Jürgen , Neusser Silke , Blase Nikola 
Published: April 2024

Background
Since fall 2020, mobile health (mHealth) apps have become an integral part of the German health care system. The belief that mHealth apps have the potential to make the health care system more efficient, close gaps in care, and improve the economic outcomes related to health is unwavering and already partially confirmed. Nevertheless, problems and barriers in the context of mHealth apps usually remain unconsidered.

Objective
The focus groups and interviews conducted in this study aim to shed light on problems and barriers in the context of mHealth apps from the perspective of patients.

Methods
Guided focus groups and individual interviews were conducted with patients with a disease for which an approved mHealth app was available at the time of the interviews. Participants were recruited via self-help groups. The interviews were recorded, transcribed, and subjected to a qualitative content analysis. The content analysis was based on 10 problem categories (“validity,” “usability,” “technology,” “use and adherence,” “data privacy and security,” “patient-physician relationship,” “knowledge and skills,” “individuality,” “implementation,” and “costs”) identified in a previously conducted scoping review. Participants were asked to fill out an additional questionnaire about their sociodemographic data and about their use of technology.

Results
A total of 38 patients were interviewed in 5 focus groups (3 onsite and 2 web-based) and 5 individual web-based interviews. The additional questionnaire was completed by 32 of the participants. Patients presented with a variety of different diseases, such as arthrosis, tinnitus, depression, or lung cancer. Overall, 16% (5/32) of the participants had already been prescribed an app. During the interviews, all 10 problem categories were discussed and considered important by patients. A myriad of problem manifestations could be identified for each category. This study shows that there are relevant problems and barriers in the context of mHealth apps from the perspective of patients, which warrant further attention.

Conclusions
There are essentially 3 different areas of problems in the context of mHealth apps that could be addressed to improve care: quality of the respective mHealth app, its integration into health care, and the expandable digital literacy of patients.