bluuebunny/crossref_metadata_2025_split huggingface dataset:
PARKİNSON HASTALIĞI İLE TIRAP GEN POLİMORFİZMİ ARASINDAKİ İLİŞKİNİN ARAŞTIRILMASI
Authors: KIR KAYAN Merve , ŞAHİN CALAPOĞLU Nilüfer 
Published: March 2024

Amaç
Parkinson hastalığı (PH), beyinde dopamin üreten
hücrelerin kaybıyla ilerleyen bir hastalıktır. PH’li hastaların
beyin dokularında α-sinüklein adlı bir protein
birikir ve nöroinflamasyona neden olur. Nöroinflamasyon,
beyindeki bağışıklık sistemi hücrelerinin aktivasyonu
ve iltihaplanma ile ilgili moleküllerin salınımını
içerir. Bu süreçte rol oynayan Toll Like Reseptör
(TLR)’ler patojenleri ve hasarlı hücreleri tanıyarak
bağışıklık yanıtını başlatır. Bu çalışmada, TLR sinyal
yolağında yer alan bir adaptör protein olan Toll/IL-1
reseptör ilişkili protein (TIRAP) gen bölgesi üzerindeki
polimorfik allelin PH’li hastalarda ve kontrol grubunda
karşılaştırmalı olarak ilişkisini araştırmayı amaçladık.
Gereç ve Yöntem
Çalışmaya 39 PH hastası ve 40 sağlıklı kişi katıldı.
Katılımcılardan kan örnekleri alınarak DNA izolasyonu
yapıldı. TIRAP rs8177374 (975C/T) polimorfizmi
PCR ve RFLP yöntemleri ile belirlendi.
Bulgular
T allel frekansı PH hastalarında 0,218; kontrol grubunda
ise 0,200 olarak bulundu. C allel frekansı ve
CC genotip frekansı her iki grupta da yüksek bulundu.
F değeri PH hastalarında 0,128; kontrol grubunda
ise 0,250 olarak bulundu. OR değeri 1,115; CI değeri
ise [0,517-2,402] olarak bulundu. Total OR=1,508;
P=0,758 olarak bulundu.
Sonuç
TIRAP polimorfizmi ile PH arasında istatistiksel olarak
anlamlı bir ilişki bulunmadı. TIRAP polimorfizminin PH
hastalarında risk faktörü olmadığı sonucuna varıldı.
YENİ NESİL BİLGİSAYAR DESTEKLİ SİMÜLASYON MAKETİNDE KARDİYOPULMONER RESÜSİTASYON EĞİTİMİNİN ASİSTAN EĞİTİMİNDEKİ ETKİNLİĞİ
Authors: ÖZDEN Eyyüp Sabri , ÖZCAN Mustafa Soner , KARABACAK Pınar , KAPLAN Burcu , ALKAYA Filiz , KIRDEMİR Pakize 
Published: March 2024

Amaç
Kardiyopulmoner resüsitasyon (KPR) uygulamalarında,
lisans ve lisansüstü tıp eğitiminde simülasyon
teknolojisi kullanımı giderek artmaktadır. Sürekli eğitimin
bir parçası olan resüsitasyon eğitiminde yeni nesil
bilgisayar destekli simülasyon maketi (YNBDSM)
kullanımı ile asistanların bilgi düzeylerinin gelişimi
araştırıldı.
Gereç ve Yöntem
Eğitime 21 klinikten 192 asistan çağrıldı. Toplam 125
asistan eğitime katıldı. 10 kişilik gruplar halinde toplam
3 makette 3 eğitimci ile 2 saat süre ile KPR eğitimi
verildi. Eğitim öncesi katılımcılara 50 soruluk doğru/
yanlış testi yapıldı. 100 puan üzerinden değerlendirildi.
2 saatlik uygulamada asistanlar birebir YNBDSM
üzerinde havayolu açma manevraları, solunum, kompresyon
ve defibrilasyon gibi resüsitasyon aşamalarını
uyguladı. Tüm asistanlar YNBDSM tabletinde
uygun kompresyon derinliğini gösteren gösterge ile
hastaya etkin kompresyon yapıldığı anlaşılarak resüsitasyonu
uyguladı. Maketin monitöründe şoklanabilir
ve şoklanamaz tüm ritimler gösterilerek, senaryolar
oluşturularak ileri yaşam desteği algoritması uygulandı.
Eğitim sonrası katılımcılara aynı doğru/yanlış testi
verildi. İlk ve son test karşılaştırması cinsiyet, klinik ve
asistan eğitim yıllarına göre yapıldı.
Bulgular
Resüsitasyon öncesi test (RÖT) ve resüsitasyon sonrası
test (RST) puanlarının karşılaştırılmasında anlamlı
farklılık gözlenmiştir. 0-1 yıl, 2-3 yıl ve 3 yıldan
fazla çalışanlarda RÖT ve RST puanları arasında istatistik
olarak anlamlı farklılık gözlendi. RÖT ile RST
puanları ve RST ile RÖT-RST farkı arasında istatistik
olarak anlamlı pozitif bir korelasyon, RÖT ile RÖTRST
farkı arasında istatistik olarak anlamlı negatif korelasyon
tespit edilmiştir.
Sonuç
Çalışmalarda resüsitasyon eğitiminde simülasyonun
kullanılması eğitim sonuçlarını iyileştirdiği, resüsitasyon
yönergelerine daha iyi uyum sağlandığı gösterilmiştir.
Yeni nesil bilgisayar destekli simülasyon maketinde
asistanların görerek ve uygulayarak yaptığı KPR
eğitiminin bilgi düzeylerini geliştirmede etkin olduğu
kanısındayız.
THE EFFECT OF VOLUME STATUS ON QUALITY OF LIFE, ANXIETY, DEPRESSION AND SLEEP QUALITY IN HEMODIALYSIS PATIENTS
Authors: ÇELİKDELEN Selma Özlem 
Published: March 2024

Objectives
To determine the volume status of patients undergoing
hemodialysis using the bioimpedance method and to
investigate the relationship of volume status with the
patients’ quality of life, anxiety, depression, and sleep
quality.
Material and Method
This cross-sectional study included a total of 100
patients undergoing hemodialysis at the Hemodialysis
Unit in March 2016. The volume status of the patients
was determined using bioelectrical impedance
analysis (BIA) performed with a body composition
monitor before their mid-week hemodialysis sessions.
The quality of life was evaluated using the 36-item
Short Form Survey, sleep quality was assessed using
the Pittsburg Sleep Quality Index (PSQI), depression
screening was performed with the Beck Depression
Inventory, and anxiety screening was undertaken with
the Beck Anxiety Inventory. The patients were divided
into three groups according to the extracellular fluid/
total body fluid (ECF/TBF) ratio, which is one of the
BIA parameters: Group 1,
ÇOCUKLUK DÖNEMİNDE ANAFİLAKSİ: TEK MERKEZ DENEYİMİ
Authors: MASLAK İbrahim Cemal 
Published: March 2024

Amaç
Anafilaksi ani başlangıçlı, hayatı tehdit eden, sistemik
alerjik bir reaksiyondur. Bu çalışmada anafilaksi tanısı
ile takip ettiğimiz olguların demografik özelliklerini,
klinik bulgularını, anafilaksi tetikleyicilerini ve ilk basamak
tedavide adrenalin kullanım durumunu değerlendirmeyi
amaçladık.
Gereç ve Yöntem
Mayıs 2021- Ekim 2023 tarihleri arasında çocuk alerji
bölümünde anafilaksi tanısı ile takip edilen 0-18 yaş
arasındaki hastalar incelendi. Anafilaksi tanısı alan
olguların demografik özellikleri ve anafilaksi tanı ve
tedavi kayıt bilgileri değerlendirildi.
Bulgular
Toplam 46 anafilaksi hastası değerlendirildi. Hastaların
28’i (%61) erkek olup, ortanca yaş 3,5 (ÇAU: 1-10)
yıl idi. Tüm yaş gruplarında en sık 3 tetikleyici sırasıyla
besin (%61), ilaç (%20) ve böcek zehiri (%20)
idi. Süt, besinler içinde anafilaksiden en çok sorumlu
tetikleyici idi (%22). Olguların %28’ i ağır anafilaksi tanısı
ile takip ediliyordu. Birinci basamak tedavisinde
adrenalin kullanım oranı %52 idi.
Sonuç
Besinler erken çocukluk döneminde anafilaksiden en
çok sorumlu olan tetikleyicilerdir. İlk başvuruda adrenalin
kullanım oranı oldukça düşüktür. Anafilaksi tanı
ve tedavisine yönelik tüm sağlık çalışanlarına yönelik
eğitim programları verilmelidir.
From the Labrador Sea to the Lincoln Sea: territorial and boundary disputes between Canada and Denmark (1970-2020s)
Authors: Volodin Dmitry 
Published: March 2024

In the 1970s two territorial disputes arose between Canada and Denmark in the Arctic: about the ownership of Hans Island and about the boundary in the Lincoln Sea. In 2005 the two countries agreed to avoid provocative actions in negotiations over Hans Island. In 2012 Canada and Denmark reached a tentative agreement on the boundary in the Lincoln Sea, which was formed on an equidistance principle. In 2022 the two countries agreed to divide Hans Island and also resolved the issue that arose in the 2010s over the delimitation of the continental shelf in the Labrador Sea. An important role in the successful resolution of these disputes was played by the Canadian-Danish Task Force on boundary issues.
Hand Function and Hand-Eye Coordination in Cervical Conditions – A Cross Sectional Study
Authors: Kumar B Senthil , R Arunachalam 
Published: March 2024

Background of the study: Cervical Conditions are most common orthopaedic condition that may affect a large number of people. It compresses the nerve roots and may cause muscle weakness, numbness and loss of fine movements of the upper limbs. Hand Functions are movements of the hand and Hand eye coordination is the coordination of motor and visual inputs to produce a movement. This study helps to find out whether the hand function and hand eye coordination are affected in Cervical Conditions.
Aim: Aim of this study is to find whether the hand function and hand eye coordination are affected in Cervical Conditions.
Method: A total number of 212 subjects with cervical pain were screened for the study inclusion criteria and 132 subjects were selected for the study. The assessment of hand function, hand-eye coordination skills and shoulder disability were carried out for all the Subjects. NDI scale was used to evaluate the subject’s severity of pain and the associated disability among the samples. Hand function we evaluated using Purdue pegboard. Ball Tossing Task and Wall Ball Bounce Task were done to assess the Hand eye coordination.
Results: On assessing the correlation between NDI and PURDUE, the results obtained on analysis is -0.108, which shows a negative relationship between the variables. The non-parametric correlation analysis using the spearman’s rho between the Neck disability index (NDI) with the PURDUE is -0.053, which shows a negative relationship between the variables. On assessing the correlation between NDI and Hand-Eye Task-1, the results obtained on analysis is -0.0081, which shows a negative relationship between the variables and the non-parametric correlation analysis is -0.162, which shows a negative relationship between the variables. On assessing the correlation between NDI and Hand-Eye Task-2, the results obtained on analysis is -0.023, which shows a negative relationship between the variables and the non-parametric correlation analysis is -0.092, which shows a negative relationship between the variables.
Discussion: The purpose of the study is to find whether the hand function and hand eye coordination are affected in Cervical Conditions.
Conclusion: This study concludes that the hand function and hand eye coordination are not affected in Cervical Conditions.
The Content and Interrelations of the Concepts of Crime Prevention (Prophylaxis and Prevention) by an Investigator
Authors: Homenko I. V. , Derishev Yu. V. 
Published: March 2024

At the present stage of the development of science, there is no consensus on the relationship between the concepts of “prevention/prophylaxis” and “prevention”/preduprezhdenie (Russian) of crimes, even despite a large number of studies on certain aspects of preventive activities of the investigator. At present, there are three main approaches to the correlation of the terms under consideration: prophylaxis and prevention as identical notions, preventive/prophylactic activity has a function of prevention, and vice versa, preventive activity acts as a generic concept for the function of prophylaxis. Crime prevention in terms of informing, warning, includes prophylaxis, prevention and suppression of crime. All these elements are the stages. And prophylaxis is the first stage of preventive activity, as it affects the causes and conditions of illegal, criminally punishable human behavior. Prophylaxis is aimed at eliminating an intent to commit a socially dangerous act by eliminating the causes and conditions that contribute to this. Prevention is aimed at inducing a person who has the intent to commit a crime to refrain from the illegal type of behavior planned by him. The suppression of a crime is aimed at stopping the implementation of a criminal plan, that is, the criminal activity that has already taken place, as well as at minimizing the criminal result. At the same time, all these elements of preventive activity take place at different points in time. However, prophylaxis can be carried out both during the investigation of a specific crime or out of it through the investigator’s talks to employees, schoolchildren, students, through studies containing information about criminal cases. The lack of a unified approach to the ratio of prophylactic and preventive activities is also due to the lack of codification of these notions. Despite the fact that the legislator focuses on the prophylaxis and prevention of specific types of crimes such as terrorism, extremism in certain regulatory legal acts, there is still no clear distinction between them.
Reservoir characteristics of the middle Eocene Avanah Formation in Erbil governorate, northern Iraq: Integration of outcrop and subsurface data
Authors: MAMASENI Wrya J. , ASAAD Irfan Sh. , AL-JUBOURY Ali I. 
Published: March 2024

The current work investigate the petrophysical characteristics of the Middle Eocene Avanah Formation in the Erbil Governorate using IP software to analyze the well data, integrated with the
petrographic investigation of the formation in the nearest outcrop in the Gomaspan section. Well logging data revealed that the main lithology of the formation is limestone and dolostone while the lithology in the Gomaspan section is composed of limestone, dolomitic limestone, marly dolomitic limestone, and thin beds of shale. The lower dolomitic unit in the subsurface section of the formation is believed to be the most suitable reservoir unit due to good petrophysical characteristics including, low water saturation, high porous medium, and the presence of movable hydrocarbon. To measure porosities, a variety of well logging techniques were used in this study. The investigated formation was divided into Avanah dense (limestone unit) and Avanah porous (dolostone unit) based on their porous components. The petrographic study shows that most pore types of the formation are secondary and represented mainly by vuggy, moldic, intercrystalline, and fracture types. Most of the fractures in the upper limestone units are filled by calcite cement. The study claimed that the lower part of the formation (dolostone unit) in both sections is considered a good reservoir.
Development of digital financial instruments and their use in the activities of entities of the pharmaceutical industry of Ukraine
Authors: Manoylenko Oleksandr , Kuznetsova Svitlana 
Published: March 2024

The pharmaceutical industry of Ukraine is an important component of its economy and the health of its population. At all stages of its development, it was and remains the centre of innovations, where the scientific and technological potential of the region is concentrated.
Theoretical and practical aspects of the development of innovative digital financial instruments and financial support were investigated and on their basis the activities of enterprises of the pharmaceutical industry in the conditions of the digital economy and electronic commerce as the most perspective segment of the modern market in the conditions of restrictions on direct contacts and the movement of people due to measures to combat the pandemic have been studied, military actions and security of people have been studied. It was determined that financial instruments can be conditionally divided into traditional and digital. They have similar content, functions, and features, however, they have different spheres of manifestation, advantages, disadvantages, and risks. At the same time, the implementation of digital financial instruments allows to significantly save the time of entrepreneurs and customers or services; it also saves cash; simplifies administration and, as a result, it increases the profitability of enterprises, in particular, the pharmaceutical industry.
The study shows wide opportunities for the development and application of embedded finance in the pharmaceutical sphere with the aim of increasing business profitability by saving time, premises and other means of providing and implementing financial activities; and economic benefits to consumers and partners; optimization of business processes and management of activities in general; promotion of innovation, investment and integration processes.
Redesain Pengisian Kekosongan Jabatan Wakil Presiden Menurut Konstitusi
Authors: Susanto Antono Adhi , Sujatnika Ghunarsa 
Published: March 2024

AbstractThe regulation of the period for filling the vacant position of Vice President as stipulated in Article 8 paragraph (2) of the 1945 Constitution of the Republic of Indonesia (Constitution) only governs the duration of People’s Consultative Assembly (MPR) sessions. Nonetheless, it does not govern the appointment of the elected Vice President. Therefore, it left problems in the effectiveness and efficiency of electing the Vice President. This research focused on two issues, the practice of filling the Vice President’s vacant position in Indonesia and its ideal concept in Indonesia. This research applies normative legal research method with a comparative approach to provisions related to the Vice President’s vacant position in several countries. In the end, the conclusion shows two findings. First, after the amendment to the Constitution, a mechanism for filling the vacant position of Vice President has been regulated, supported by two factors, Vice President is a constitutional position, also because of the effectiveness and efficiency of the elections through the MPR. Second, Article 8 paragraph (2) of the Constitution needs to be revised by requiring one candidate, limiting the period for the Vice President’s election to seven days, as well as amending MPR’s authority to approve and fill the position of interim Vice President. Keywords: Redesign; Filling Post; Vice President.
AbstrakPengaturan jangka waktu pengisian kekosongan jabatan Wakil Presiden dalam Pasal 8 ayat (2) Undang-Undang Dasar Negara Republik Indonesia Tahun 1945 hanya mengatur waktu sidang MPR dan bukan mengatur penetapan Wakil Presiden terpilih, sehingga masih terdapat permasalahan efektivitas dan efisiensi terpilihnya Wakil. Penelitian ini mengkaji dua hal, yaitu praktik pengisian kekosongan jabatan Wakil Presiden di Indonesia dan konsep ideal pengisian kekosongan jabatan wakil presiden di Indonesia. Penelitian ini menggunakan metode penelitian hukum normatif dengan pendekatan perbandingan pengaturan kekosongan jabatan Wakil Presiden pada konstitusi beberapa negara. Hasil penelitian menyimpulkan, Pertama, pasca amendemen UUD 1945 telah diatur mekanisme pengisian kekosongan jabatan Wakil Presiden karena Wakil Presiden merupakan jabatan konstitusional dan mempertimbangkan faktor efektivitas dan efisien dengan pemilihan melalui MPR. Kedua, Pasal 8 ayat (2) UUD 1945 perlu diperbaiki dengan mengatur satu orang calon, pembatasan waktu terpilihnya Wakil Presiden menjadi tujuh hari, perubahan peran MPR untuk melakukan persetujuan dan pengisian jabatan Wakil Presiden sementara.Kata Kunci: Redesain; Pengisian Jabatan; Wakil Presiden.
Analisis keaktifan belajar ditinjau dari gaya belajar peserta didik selama masa pandemi covid-19 pada peserta didik kelas V SDN Joho 01 tahun pelajaran 2021/2022
Authors: Rosyana Kurniasari Elsya , Riyadi Riyadi , Sriyanto M. Ismail 
Published: March 2024

<p class="Abstract"><em>This study aims to describe the student’s learning agility based on their learning styles category (visual, auditory, kinesthetic) and the challenges in learning agility of </em><em>fifth grade</em><em> students of Joho 01</em><em> Elementary School</em><em> during the Covid-19 pandemic. The type of research used in this study was qualitative-descriptive with a case study approach. Techniques for collecting data include surveys, observations, interviews, and documentation. The data validity test technique employs both time and technological triangulation. The data analysis utilizes Miles and Huberman techniques such as gathering data, decreasing data, presenting data and drawing conclusions.</em><em> </em><em>The result of this study shows that each learning styles category has varied learning agility. Students with visual learning have a moderate level of learning agility with difficulties in listening</em><em>, speaking</em><em> and motoric indicators</em><em>.</em><em> </em><em>S</em><em>tudents with auditory learning styles have a high level of learning agility with difficulties in problem-solving indicators, while students with kinesthetic learning styles have both high and moderate levels of active learning with difficulties in visual, auditory and emotional indicators. The learning style with the highest level of agility in students of g</em><em>rade V</em><em> SD Negeri Joho 01 is the auditory learning style.</em></p>
Hubungan antara kompetensi profesional guru dan disiplin belajar terhadap hasil belajar IPA materi panas dan perpindahannya kelas V sekolah dasar
Authors: Mahmudah Nurul , Rintayati Peduk , Adi Fadhil Purnama 
Published: March 2024

<p><em>The purpose of this research is to 1) determine whether there is a relationship between teacher professional competence and science learning outcomes; 2) the relationship between learning discipline and science learning outcomes; 3) the relationship between teacher professional competence and learning discipline together with science learning outcomes. The method used is a correlational method. The sample is 86 students in grade 5<sup>th</sup> of 3 elementary schools. Data collection techniques use tests in the form and questionnaires. The data analysis technique used in this research is simple correlation analysis and double correlation analysis. Based on the results of data analysis, it can be concluded that 1) there is a significant relationship between teacher professional competence and science learning outcomes, namely the correlation coefficient r<sub>count</sub> (0.457) &gt; r<sub>table</sub> (0.217) with a significance of t<sub>count</sub> (4.712) &gt; t<sub>table</sub> (1.988); there is a significant relationship between learning discipline and science learning outcomes with a correlation coefficient of r<sub>count </sub>(0.642) &gt; r<sub>table</sub> (0.217) with a significance of t<sub>count</sub> (7.67) &gt; t<sub>table </sub>(1.988); there is a significant relationship between teacher professional competence and learning discipline together with science learning outcomes, namely </em><em> (0.687) &gt; r<sub>table</sub> (0.217), the significance of F<sub>count</sub> (37.0037) &gt; F</em><sub>table </sub><em>(3.1065)</em></p>
Tingkat kemampuan literasi digital peserta didik kelas V SD se-Kecamatan Laweyan
Authors: Nafisah Ainun , Atmojo Idam Ragil Widianto , Ardiansyah Roy 
Published: March 2024

<p class="15">The purpose of this study was to determine the level of digital literacy of fifth grade elementary school students in Laweyan District. The research method used is quantitative. The sample of this study was 86 students from 4 elementary schools in Laweyan District, class V. The data collection technique used is a test. Data analysis used descriptive statistical analysis. The results of this study are that the digital literacy level of fifth grade elementary school students in Laweyan District is mostly in the high category, which is 50%. Meanwhile students with very high category were 31.4%, low category were 1.2%, medium category were 17.4%. This research can be used as a reference to measure the level of digital literacy of students.</p><p> </p>