bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lung volume reduction surgery by intra-bullous fibrin sealant application using thoracoscopy, an alternative in the management of vanishing lung syndrome
Authors: Zuo Ling , Wang Kaige , Li Weimin , Shi Jingyu , Tan Fen , Liu Dan , Luo Fengming 
Published: March 2024

Abstract
Background: To investigate the efficacy of lung volume reduction surgery (LVRS) through the application of intra-bullous fibrin sealant using thoracoscopy in patients diagnosed with vanishing lung syndrome(VLS).
Methods: A retrospective analysiswas conducted on the clinical data of patients with VLS who were admitted to the West China Hospital of Sichuan University between March 2022 and September 2023. Patients who met the inclusion criteria underwent LVRS and were followed up to evaluate the efficacy and safety of the technique.
Results: A total of seven male patients were included, with a median age of 61 years. The patients' post-operative activity tolerance, as assessed by the chronic obstructive pulmonary disease assessment test (CAT) score and the 6-minute walk test (6-MWT), showed continuous significant improvement. Besides, five patients injected with at least 20 mL of fibrin sealant underwent successful reduction and received double-lumen endotracheal intubation while under anesthesia. The operation failed in two patients with fibrin sealant injection volume less than 12 mL. However, no significant postoperative complications were observed except for one patient with 20 mL pleural hemorrhage and a maximum of 28 days of postoperative air leakage.
Conclusion: The application of intra-bullous fibrin sealant through thoracoscopy is a safe and effective approach for managing VLS, resulting in minimal wound and fewer complications. The success of this strategy depends on using dual lumen tracheal intubation to block lung ventilation and applying the appropriate amount of fibrin sealant.
Retrospective trial registration: (Chinese Clinical Trial Center, registration number: ChiCTR2300078038, registered 2023-11-27)
Primary extrauterine endometrial stromal sarcoma with multiple organ invasion: A case report
Authors: Xu Yan , Niu Jumin , Zhou Yang , Nie Xiaocui , Liu Yansong 
Published: March 2024

Abstract
Background: Primary extrauterine endometrioid stromal sarcoma (EESS) are rarer tumors that occur outside the uterus and do not involve the uterus.
Case presentation: We report a case of low-grade extrauterine endometrial stromal sarcoma of the pelvic and colorectum. A 46-year-old woman, who complained of diarrhea with yellow mucus-like or elongated stools for more than 2 months, came to our hospital with colonoscopy and CT results that raised suspicion of colorectal cancer but also pathological examination results indicative of endometriosis. As the intraoperative pathology of the omentum and ovary revealed endometrial stromal sarcoma, and part of the sigmoid and rectum were obviously thickened and stiff, we performed cytoreductive surgery including removal of the uterus, bilateral fallopian tubes, bilateral ovaries, part of the colorectum, omentum majus, and metastatic lesions. Postoperative pathology revealed that the pelvic mass and segments from the colorectum were consistent with low-grade endometrial stromal sarcoma. Long-term oral administration of Letrozole, 2.5mg/day and Farlutal, 500mg/day was prescribed. During follow-up of the patient, the pelvic peritoneal examination results were negative, and has remained disease-free at 48-months post-surgery.
Conclusion: We report a rare case of simultaneous endometrial stromal sarcoma of the pelvic and colorectum.
High hyperdiploid karyotype with ≥49 chromosomes represents a heterogeneous subgroup of acute myeloid leukemia with differential TP53 mutation status and prognosis: a single-center study from China
Authors: Zhang Zhiyu , Fu Chunmei , Sun Yingxin , Liu Yizi , Wang Qian , Yan Wanhui , Wu Chunxiao , Wang Qinrong , Zeng Zhao , Wen Lijun , Shen Hongjie , Yao Li , Liu Dandan , Chen Su-ning , Pan Jinlan 
Published: March 2024

Abstract

High hyperdiploid karyotype with ≥49 chromosomes (which will be referred to as HHK) is rare in acute myeloid leukemia (AML). The European leukemia network (ELN) excluded those harboring only numerical changes (with ≥3 chromosome gains) from CK and listed them in the intermediate risk group, while the UK National Cancer Research Institute Adult Leukaemia Working Group classification defined ≥4 unrelated chromosome abnormalities as the cutoff for a poorer prognosis. Controversies occurred among studies on the clinical outcome of HHK AML, and their molecular characteristics remained unstudied. We identified 1.31% (133/10131) HHK cases within our center, among which 48 cases only had numerical changes (NUM), 42 had ELN defined adverse abnormalities (ADV) and 43 had other structural abnormalities (STR). Our study demonstrated that: (1) No statistical significance for overall survival (OS) was observed among three cytogenetic subgroups (NUM, STR and ADV) and HHK AML should be assigned to the adverse cytogenetic risk group. (2) The OS was significantly worse in HHK AML with ≥51 chromosomes compared with those with 49-50 chromosome. (3) Gaining of chromosome 11 alone was associated with a poorer prognosis in ADV subgroup. (4) The clinical characteristics were similar between NUM and STR group compared to ADV group. The former two groups had higher white blood cell counts and blasts, higher percentage of M5 and mutations associated with signaling, while the ADV group exhibited older age, higher chromosome counts, higher percentage of myelodysplastic syndrome (MDS) history, and a dominant TP53 mutation.
Inhalation motion analysis and visualization of error areas using two IMU sensors
Authors: Hasegawa Atsushi , Shimono Tomoyuki , Masaki Katsunori , Takano Shunya , Nakada Hideo , Hakamata Jun , Kabata Hiroki , Miyata Jun , Fukunaga Koichi 
Published: March 2024

Abstract
This paper proposes an inhaler-use behavior evaluation method that uses inertial sensors to monitor patients with bronchial asthma and chronic obstructive pulmonary disease (COPD). COPD is common disease, and the accurate use of inhalers is vital to controlling its symptoms. However, many patients improperly use their inhalers. Hence, by augmenting an Ellipta™ inhaler with inertial measurement units, this study evaluates patient inhalation motions using the acquired motion data. Compared with conventional methods, ours is less affected by external factors, such as sound and temperature, and it can be applied outside clinical settings. Specifically, a linear discriminant analysis algorithm is provided for selecting characteristic variables for each error type, and a judgment method using these variables is proposed. A dynamic programming matching algorithm is then applied to determine correctness. Experimental results show that our method provides high discriminant accuracy, and it accounts for the similarity of waveforms, which allows us to visualize errors, unlike contemporary methods. We expect that our inhalation method and the accompanying dataset will offer valuable guidance for future research as well as useful feedback to patients.
The influence of nickel electrode's morphology on glucose detection
Authors: Hu Hailong , Ma Guohua , Guo Baogang , Zhang Xingquan , Xie Ruishi , Liu Haifeng , Huang Heyan 
Published: March 2024

Abstract
Different morphology metal nickel nanoelectrodes, such as nano spikes, layered nanosheets, layered flat particles, and hierarchical nanosheets were prepared on FTO glass by hydrothermal method, and were used to determine glucose concentration in aqueous solution under alkaline condition. All electrodes exhibit different electrochemical catalytic characteristics such as surface area, mass transfer, and catalytic rate in the progress of glucose oxidation. It was to note, larger surface area can produce a larger redox current in the absence of glucose, and a larger current noise, longer response time in the present of glucose. All of the electrodes have a similar surface coverage, and electrodes with larger surfaces have more Ni2+/Ni3+ redox couples and yield more redox current in alkaline solution. However, poor catalytic rate for glucose can result in low sensitivity for glucose detection for electrodes. That means not all of the redox couples on the electrodes surface involved in the glucose oxidation, even if the electrodes have large glucose coverage and more redox couples. Furthermore, electrodes with a larger surface area have larger surface roughness, which decreases glucose diffusion and results in a longer response time in amperometric detection.
PBP-A, a cyanobacterial DD-peptidase with high specificity for amidated muropeptides, exhibits pH-dependent promiscuous activity harmful to Escherichia coli
Authors: Dorrazehi Gol Mohammad , Winkle Matthias , Desmet Martin , Stroobant Vincent , Tanriver Gamze , Degand Hervé , Evrard Damien , Desguin Benoît , Morsomme Pierre , Biboy Jacob , Gray Joe , Mitusińska Karolina , Góra Artur , Vollmer Waldemar , Soumillion Patrice 
Published: March 2024

Abstract

Penicillin binding proteins (PBPs) are involved in biosynthesis, remodeling and recycling of peptidoglycan (PG) in bacteria. PBP-A from Thermosynechococcus elongatus belongs to a cyanobacterial family of enzymes sharing close structural and phylogenetic proximity to class A b-lactamases. With the aim of converting PBP-A into a b-lactamase, we expressed the enzyme in the periplasm of Escherichia coli but failed in directed evolution experiments and observed growth defect associated with the enzyme activity. To further explore the molecular origins of this harmful effect, we decided to characterize deeper the activity of PBP-A both in vitro and in vivo. We found that PBP-A is an enzyme endowed with DD-carboxypeptidase and DD-endopeptidase activities, featuring high specificity towards muropeptides amidated on the D-iso-glutamyl residue. We also show that a low promiscuous activity on non-amidated peptidoglycan deteriorates E. coli’s envelope, which is much higher under acidic conditions where substrate discrimination is mitigated. Besides expanding our knowledge of the biochemical activity of PBP-A, this work also highlights that promiscuity may depend on environmental conditions and how it may hinder rather than promote enzyme evolution in nature or in the laboratory.
Evaluation of Transformer-Based Neural Language Models for Writing Feedback and Automated Essay Scoring
Authors: Abraha Temesgen , Nazir Amril 
Published: March 2024

Abstract

Writing remains a challenging skill for many students due to inadequate feedback tools. There is a need to develop more effective tools for supporting students’ writing skill development. This study aims to evaluate the effectiveness of transformer-based neural language models for assessing and automatically scoring argumentative essays written by 8th-12th grade English Language Learners (ELLs). The students’ English essays were assessed and scored based on six criteria, including cohesion, syntax, vocabulary, phraseology, grammar, and conventions. The models were trained on real teacher feedback from 2700 scored essays. We also compared various transformer-based neural language models to find the most effective model. Several metrics were used for evaluation, with the root mean square error (RMSE) as the primary measure. The results show that a specific model, DeBERTa-v3-large, outperforms others in most categories. In conclusion, this study suggests that transformer-based neural language models, especially when using the DeBERTa-v3-large model, hold significant promise in improving automated essay scoring and feedback, potentially leading to enhanced writing skills among English language learners.
A study on the relative motion trajectory of lumbar pedicles under physiological loads in vivo
Authors: Huang Caiyun , Wen Wangqiang , Wu Jincheng , Chen Tao , Li Guojun , Tang Songjie , He Xiaoyuan , Chen Huanxiong 
Published: March 2024

Abstract

Purpose: There are limited data on the natural kinematics of the lumbar pedicle in vivo. This study investigated the range of motion of the lumbar pedicle screw insertion point when normal subjects moved under physiological loads.
Methods: Ten healthy volunteers aged 25 to 39 years were recruited. A combination of a dual fluoroscopic imaging system (DFIS) and CT technology was used. With computer assistance, a three-dimensional reconstructed model of each segment of the lumbar spine was created by using the subject's lumbar spine CT and matched to dual oblique X-ray fluoroscopic images of the lumbar spine in different active positions captured by the DFIS. The combination can accurately reproduce the three-dimensional motion state of lumbar intervertebral bodies under physiological load. By measuring the changes in the three-dimensional coordinate system of the simulated pedicle screw insertion point, the in-body kinematic data of adjacent lumbar pedicles under physiological load were finally obtained.
Results: During flexion and extension, the lumbar pedicle screw insertion point deviated <3 mm along the cranial axis (P<0.05) and rotated <4° around the mediolateral axis (P<0.05). During left–right bending movements, the lumbar pedicle screw insertion point deviated along the mediolateral and cranial axes (P<0.05), with the largest deviation (<2.5 mm) on the mediolateral axis at the L3–4 segment, and rotated <5° around the anterior–posterior axis (P<0.05). During left–right rotation, the lumbar pedicle screw insertion point deviated <2 mm along the cranial axis (P<0.05). Its primary rotation axis was the cranial axis, <3° around the coupling axis and the anterior-posterior axis (P<0.05). There were differences in the deviation measurement of the left and right sides during flexion-extension and bending, as well as in the true distance of the pedicle screw insertion point during bending (p<0.05).
Conclusion: The movement patterns of the lumbar pedicles are inconsistent under different postures, and there is left and right asymmetric movement. Coupling will occur during complex movements.
Estrogen receptor (ER)- and progesterone receptor (PR)-dependent expression of NINJ1, a cell-surface executioner of active cell rupture, in breast cancer, with implications in prognosis
Authors: BERKEL CAGLAR 
Published: March 2024

Abstract
NINJ1 (Ninjurin 1) mediates plasma membrane rupture (PMR) during lytic phase in response to inducers of different programmed cell death mechanisms such as pyroptosis, which leads to release of inflammatory molecules such as HMGB1 and LDH. However, NINJ1 has not been studied in the context of breast cancer. Here, I found that NINJ1 transcript levels are higher in breast tumors than in non-malignant breast tissue. Estrogen receptor (ER)-positive or progesterone (PR)-positive breast cancer cells have higher expression of NINJ1 than ER-negative or PR-negative breast cancer cells, respectively; and, this is independent of menopausal status. In contrast, NINJ1 expression does not differ based on HER2 status, another molecular marker used to define breast cancer subtypes. Lowest expression of NINJ1 is observed in triple negative breast cancer (TNBC). Tumor stage and race might also influence NINJ1 mRNA expression levels in breast cancer. More importantly, breast cancer patients with high NINJ1 expression have a more favorable prognosis than those with low NINJ1 expression. Higher NINJ1 levels in hormone receptor (HR)-positive (ER-positive and PR-positive) breast cancer might contribute to better survival rates observed in this patient group compared to breast cancer patients with HR-negative status. Mechanistic details of how NINJ1 influence antitumor immunity and patient outcomes in breast cancer remains to be studied.
Body composition, strength and muscle power indices at the different competitive levels of Futsal
Authors: Marques Catarina , Rebelo Miguel , Crisóstomo Rute , Batista Marco , Paulo Rui , Duarte-Mendes Pedro , Honorio Samuel , Serrano João 
Published: March 2024

Abstract

Background: The aim was to verify the differences in physical condition (body composition, power and muscle strength) in futsal players from three competitive levels.
Methods: Sixty-eight (24.26 ± 4.63 years) Portuguese futsal players participated in the study, divided into: elite, sub-elite and amateur. We used the Inbody270, the counter movement jump and the isokinetic dynamometer to assess physical condition, and the Kruskal-Wallis test to compare variables between groups.
Results: There were no differences in body composition between groups. Elite players had higher countermovement jump heights than amateur players (p < 0.001). There were significant differences in the isokinetic muscle strength of the knee flexors, with the elite players showing more strength than the amateur players (p = 0.047).
Conclusions: The elite players had higher physical condition parameters (more lower limb power and more flexor muscle strength) compared to the amateur players. We would point out that all groups had a high probability of lower limb muscle injury (H/Q ratio < 60%) at this stage of the sports season, alerting training professionals to the importance of individualised physical condition analysis.
Integrated Production-Maintenance Strategy considering energy consumption and recycling constraints in dry machining
Authors: Guendouli El Mehdi , Mifdal Lahcen , Dellagi Sofiene , Kibbou El Mehdi , Moufki Abdelhadi 
Published: March 2024

Abstract

The current challenge for industrial companies, involved in improving CNC - Computer Numerical Control - mechanical manufacturing machines, consists in integrating production decision aid adapted to the constraints associated with dry machining processes. This tool provides the best choice of appropriate production parameters for dry machining, which has a direct impact on productivity, system degradation and the quality of the final product. The proposed study develops an integrated production-maintenance policy which considers simultaneously several parameters related to production process and manufacturing system environment. In fact, our goal consists in determining an economical integrated production maintenance strategy that minimize the total cost including raw materials, production, recycling and maintenance. Considering two types of raw materials (steel and aluminum) and requesting to a random demand over a finite horizon dissociated to subperiods, the economical integrated maintenance-production, which is obtained by minimizing the total cost, is illustrated by the processing time of each type of raw materials for each subperiod and the optimal preventive maintenance time. The impact of the type of raw material with regard to some parameters like cutting speed, recycle cost, and the degradation system is taken into account in the determination of the economic plan. An analytical model expressing the objective function, the total cost, according to the variable decisions is developed. A numerical solving procedure, a numerical example and a sensitivity study are proposed in order to prove the developed analytical model.
Black or white, color aberrations on Rufous-collared Sparrow Zonotrichia capensis
Authors: Cadena-Ortiz Héctor , Greenfield Paul , Salagaje Luis , Piñán Diego , Narváez Rafael , Grouw Hein van 
Published: March 2024

Abstract

A review of the color aberrations in Rufous-collared Sparrow (Zonotrichia capensis) is presented, adding 62 individuals with aberrations. A full white individual and a family of four melanistic individuals were monitored in Ecuador, the first relevant for living for a considerable time with his condition and the second case for the evidence of reproduction, and the inheritance of his condition. In addition, we found 29 individuals that are documented in previous papers and another 28 from online citizen science databases (eBird and iNaturalist), covering the species’ broad distribution. We re-identified and identified the aberrations, and found individuals’ representative of seven kinds of commonest aberrations (Leucism, Progressive Greying, Albinism, Brown, Ino, Dilution, and Melanism), Progressive Greying was the most common condition encountered, with 39 individuals. Ecuador was the country with the most records, with 25 individuals. This paper aims to contribute to properly identifying color aberrations using as an example this common species and to motivate the continued formal publication of these records that have relevant implications as we discuss.
Laparoscopic hepatectomy using clamp-crush technique with non- coagulation: a retrospective study
Authors: Kitagawa Akihiro , Nakahira Shin , Maeda Sakae , Ogawa Hisataka , Kishimoto Tomoya , Ushimaru Yuki , Ohara Nobuyoshi , Miyake Yuichiro , Kawabata Ryohei , Nishikawa Kazuhiro , Noura Shingo , Irei Toshimitsu , Inoue Masashi , Miyamoto Atsushi , Hatanaka Nobutaka , Ohzato Hiroki 
Published: March 2024

Abstract

Background and aims
There is no current consensus regarding the best practices for techniques and devices in laparoscopic hepatic parenchymal transection. To compare the safety, efficacy, and outcomes between coagulation and non-coagulation while using the clamp-crush technique in modern parenchymal transections.
Methods
The clinical outcomes of patients who underwent laparoscopic liver resection for hepatocellular carcinoma and liver metastasis by coagulation with a Biclamp (n=74) and non-coagulation with a Harmonic ACE (n=92), using the clamp-crush technique, were evaluated. Additionally, we checked the fluid collection at the cut surface by obtaining a CT scan 1 month post-hepatectomy.
Results
There were no statistically significant differences in patient characteristics between the groups, except a history of liver resection, and the operative duration and frequency of the Pringle maneuver being shorter and more in the non-coagulated group. The non-coagulation group had significantly lower postoperative serum AST, ALT, and total bilirubin levels, except for serum ALT on the first postoperative day, regardless of the significantly higher preoperative serum AST and ALT levels (P<0.05). There were three cases of bile leakage in the coagulated group, but no such cases in the non-coagulated group (not statistically significant). Fluid collections of > 3 cm in diameter was significantly less in the non-coagulated group.
Conclusions
The clamp-crush technique with non-coagulation may improve the clinical outcomes of laparoscopic hepatectomy, including postoperative fluid collection at the cut liver surface.
Neuroleptic malignant syndrome in a patient with COVID-19 and the possible role of SARS-CoV-2 in its manifestation. Case report and overview of published cases
Authors: SKRONT Tomas , SAGAN Jiri , HYZA Martin 
Published: March 2024

Abstract
Background: The manifestationof severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is more complex than that of pulmonary infection, and neuropsychiatric symptoms play a role in this complexity. In this paper, we present the case of a 29-year-old schizophrenic patient who suffered from neuroleptic malignant syndrome (NMS) that developed during coronavirus disease 2019 (COVID-19) infection, with an emphasis on the possible connection between these two conditions. Additionally, we provide an overview of published NMS cases in patients with COVID-19 or after vaccination against SARS-CoV-2.
Case presentation: A 29-year-old patient treated for schizophrenia was admitted to the hospital for agitation and aggressivity; shortly after arrival at the hospital, laryngospasm and hypoxia occurred. The patient tested positive for SARS-CoV-2, and later, he developed pneumonia. After continuing restlessness, haloperidol was administered, and a few days later, neuroleptic malignant syndrome occurred. He was treated with bromocriptine and recovered.
Conclusions: As SARS-CoV-2 is known to interact with angiotensin-converting enzyme 2 and DOPA-decarboxylase is known to be coexpressed with this receptor, we hypothesized that COVID-19 infection might playa substantial role in the development of NMS.