bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cadherin-11 Promotes the Metastasis of Prostate Cancer Cells to Bone
Authors: Chu Khoi , Cheng Chien-Jui , Ye Xiangcang , Lee Yu-Chen , Zurita Amado J. , Chen Dung-Tsa , Yu-Lee Li-Yuan , Zhang Sui , Yeh Edward T. , Hu Mickey C-T. , Logothetis Christopher J. , Lin Sue-Hwa 
Published: August 2008

Abstract
Bone is the most common site of metastases from prostate cancer. The mechanism by which prostate cancer cells metastasize to bone is not fully understood, but interactions between prostate cancer cells and bone cells are thought to initiate the colonization of metastatic cells at that site. Here, we show that cadherin-11 (also known as osteoblast-cadherin) was highly expressed in prostate cancer cell line derived from bone metastases and had strong homophilic binding to recombinant cadherin-11 in vitro. Down-regulation of cadherin-11 in bone metastasis–derived PC3 cells with cadherin-11–specific short hairpin RNA (PC3-shCad-11) significantly decreased the adhesion of those cells to cadherin-11 in vitro. In a mouse model of metastasis, intracardiac injection of PC3 cells led to metastasis of those cells to bone. However, the incidence of PC3 metastasis to bone in this model was reduced greatly when the expression of cadherin-11 by those cells was silenced. The clinical relevance of cadherin-11 in prostate cancer metastases was further studied by examining the expression of cadherin-11 in human prostate cancer specimens. Cadherin-11 was not expressed by normal prostate epithelial cells but was detected in prostate cancer, with its expression increasing from primary to metastatic disease in lymph nodes and especially bone. Cadherin-11 expression was not detected in metastatic lesions that occur in other organs. Collectively, these findings suggest that cadherin-11 is involved in the metastasis of prostate cancer cells to bone. (Mol Cancer Res 2008;6(8):1259–67)
Biogeography of Tropical Montane Cloud Forests. Part II: Mapping of Orographic Cloud Immersion
Authors: Nair Udaysankar S. , Asefi Salvi , Welch Ronald M. , Ray D. K. , Lawton Robert O. , Manoharan Vani Starry , Mulligan Mark , Sever Tom L. , Irwin Daniel , Pounds J. Alan 
Published: August 2008

AbstractThis study details two unique methods to quantify cloud-immersion statistics for tropical montane cloud forests (TMCFs). The first technique uses a new algorithm for determining cloud-base height using Moderate Resolution Imaging Spectroradiometer (MODIS) cloud products, and the second method uses numerical atmospheric simulation along with geostationary satellite data. Cloud-immersion statistics are determined using MODIS data for March 2003 over the study region consisting of Costa Rica, southern Nicaragua, and northern Panama. Comparison with known locations of cloud forests in northern Costa Rica shows that the MODIS-derived cloud-immersion maps successfully identify known cloud-forest locations in the United Nations Environment Programme (UNEP) World Conservation Monitoring Centre (WCMC) database. Large connected regions of cloud immersion are observed in regions in which the trade wind flow is directly impinging upon the mountain slopes; in areas in which the flow is parallel to the slopes, a fractured spatial distribution of TMCFs is observed. Comparisons of the MODIS-derived cloud-immersion map with the model output show that the MODIS product successfully captures the important cloud-immersion patterns in the Monteverde region of Costa Rica. The areal extent of cloud immersion is at a maximum during morning hours and at a minimum during the afternoon, before increasing again in the evening. Cloud-immersion frequencies generally increase with increasing elevation and tend to be higher on the Caribbean Sea side of the mountains. This study shows that the MODIS data may be used successfully to map the biogeography of cloud forests and to quantify cloud immersion over cloud-forest locations.
Characterizing Variability of the Urban Physical Environment for a Suite of Cities in Rondônia, Brazil
Authors: Powell Rebecca L. , Roberts Dar A. 
Published: August 2008

AbstractUrban environments are characterized by high spectral and spatial heterogeneity and, as a consequence, most urban pixels in moderate-resolution imagery contain multiple land-cover materials. Despite these complexities, virtually all urban land cover can be generalized as a combination of vegetation, impervious surfaces, and soil (V–I–S components), in addition to water. Previous work has demonstrated the potential of multiple endmember spectral mixture analysis (MESMA) to model the subpixel abundance of V–I–S components. Here, the authors test whether the technique is sufficiently robust to map V–I–S components for a diverse set of cities, selecting 10 urban centers in the state of Rondônia, Brazil, to represent a range of populations, development histories, and economic activities. For each urban sample, a 20 km × 20 km region centered over the built-up area was subset from Landsat Enhanced Thematic Mapper Plus (ETM+) imagery. MESMA was applied to all subscenes using the same spectral library, model constraints, and selection rules. Accuracy of the modeled V–I–S fractions was assessed using high-resolution images mosaicked from digital aerial videography. Modeled fractions and reference fractions were highly correlated, with R2 values exceeding 0.75 for all materials in multiple cities across a region. Model complexity, or the number of endmembers required to accurately model each pixel, was correlated with the degree of human impact on the landscape. Built-up areas, as delineated by model complexity, exhibited a strong fit to the well-established relationship between the built-up area of a settlement and its population. Finally, this work demonstrates that the V–I–S components as modeled by MESMA can capture both inter- and intraurban variability, suggesting that these data products could contribute to comparative studies of urbanizing areas through time and across regions.
Tropical Atmosphere–Ocean Interactions in a Conceptual Framework
Authors: Jansen Malte F. , Dommenget Dietmar , Keenlyside Noel 
Published: August 2008

Abstract
Statistical analysis of observations (including atmospheric reanalysis and forced ocean model simulations) is used to address two questions: First, does an analogous mechanism to that of El Niño–Southern Oscillation (ENSO) exist in the equatorial Atlantic or Indian Ocean? Second, does the intrinsic variability in these basins matter for ENSO predictability? These questions are addressed by assessing the existence and strength of the Bjerknes and delayed negative feedbacks in each tropical basin, and by fitting conceptual recharge oscillator models, both with and without interactions among the basins.
In the equatorial Atlantic the Bjerknes and delayed negative feedbacks exist, although weaker than in the Pacific. Equatorial Atlantic variability is well described by the recharge oscillator model, with an oscillatory mixed ocean dynamics–sea surface temperature (SST) mode present in boreal spring and summer. The dynamics of the tropical Indian Ocean, however, appear to be quite different: no recharge–discharge mechanism is found. Although a positive Bjerknes-like feedback from July to September is found, the role of heat content seems secondary.
Results also show that Indian Ocean interaction with ENSO tends to damp the ENSO oscillation and is responsible for a frequency shift to shorter periods. However, the retrospective forecast skill of the conceptual model is hardly improved by explicitly including Indian Ocean SST. The interaction between ENSO and the equatorial Atlantic variability is weaker. However, a feedback from the Atlantic on ENSO appears to exist, which slightly improves the retrospective forecast skill of the conceptual model.
The Control of Polar Haloclines by Along-Isopycnal Diffusion in Climate Models
Authors: Sijp Willem P. , England Matthew H. 
Published: August 2008

Abstract
Increasing the value of along-isopycnal diffusivity in a coupled model is shown to lead to enhanced stability of North Atlantic Deep Water (NADW) formation with respect to freshwater (FW) perturbations. This is because the North Atlantic (NA) surface salinity budget is dominated by upward salt fluxes resulting from winter convection for low values of along-isopycnal diffusivity, whereas along-isopycnal diffusion exerts a strong control on NA surface salinity at higher diffusivity values. Shutdown of wintertime convection in response to a FW pulse allows the development of a halocline responsible for the suppression of deep sinking. In contrast to convection, isopycnal salt diffusion proves a more robust mechanism for preventing the formation of a halocline, as surface freshening leads only to a flattening of isopycnals, leaving at least some diffusive removal of anomalous surface FW in place. As a result, multiple equilibria are altogether absent for sufficiently high values of isopycnal diffusivity. Furthermore, the surface salinity budget of the North Pacific is also dominated by along-isopycnal diffusion when diffusivity values are sufficiently high, leading to a breakdown of the permanent halocline there and the associated onset of deep-water formation.
Polarimetric and Dual-Doppler Radar Observations of the Lipscomb County, Texas, Supercell Thunderstorm on 23 May 2002
Authors: Frame Jeffrey , Markowski Paul , Richardson Yvette , Straka Jerry , Wurman Joshua 
Published: August 2008

Abstract
Polarimetric and dual-Doppler observations of a supercell observed by the National Center for Atmospheric Research (NCAR) S-band Polarimetric (SPOL) radar, two Doppler-On-Wheels (DOW) radars, and the Greek XPOL radar on 23 May 2002 during the International H2O Project (IHOP) are presented. The polarimetric radar observations began as the storm organized into a supercell and continued for over an hour while the storm was in its mature phase. The hydrometeor distribution within the mature storm was retrieved using a fuzzy logic hydrometeor classification algorithm. The dual-Doppler radar observations began around the time that the polarimetric radar observations concluded, and they covered the end of the mature phase and much of the dissipation phase of the storm. The dual-Doppler wind syntheses are used to evaluate the importance of the forward-flank outflow in augmenting the horizontal vorticity field near the storm above 400 m. In this case, having a relatively weak low-level mesocyclone, the parcel trajectories and the horizontal vorticity field observed within the forward-flank outflow are not what one would likely expect based on prior numerical studies (having generally stronger low-level mesocyclones) that have emphasized an important dynamical role for forward-flank downdrafts in terms of their horizontal vorticity generation. Instead, the observed trajectories could not be traced from the forward-flank outflow toward the storm’s updraft and the horizontal vorticity vectors within the forward-flank outflow generally did not point (westward) toward the storm’s updraft.
Microphysical and Thermodynamic Structure and Evolution of the Trailing Stratiform Regions of Mesoscale Convective Systems during BAMEX. Part I: Observations
Authors: Smith Andrea M. , McFarquhar Greg M. , Rauber Robert M. , Grim Joseph A. , Timlin Michael S. , Jewett Brian F. , Jorgensen David P. 
Published: August 2008

Abstract
This study used airborne and ground-based radar and optical array probe data from the spiral descent flight patterns and horizontal flight legs of the NOAA P-3 aircraft in the trailing stratiform regions (TSRs) of mesoscale convective systems (MCSs) observed during the Bow Echo and Mesoscale Convective Vortex Experiment (BAMEX) to characterize microphysical and thermodynamic variations within the TSRs in the context of the following features: the transition zone, the notch region, the enhanced stratiform rain region, the rear anvil region, the front-to-rear flow, the rear-to-front flow, and the rear inflow jet axis. One spiral from the notch region, nine from the enhanced stratiform rain region, and two from the rear anvil region were analyzed along with numerous horizontal flight legs that traversed these zones. The spiral performed in the notch region on 29 June occurred early in the MCS life cycle and exhibited subsaturated conditions throughout its depth. The nine spirals performed within the enhanced stratiform rain region exhibited saturated conditions with respect to ice above and within the melting layer and subsaturated conditions below the melting layer. Spirals performed in the rear anvil region showed saturation until the base of the anvil, near −1°C, and subsaturation below. These data, together with analyses of total number concentration and the slope to gamma fits to size distributions, revealed that sublimation above the melting layer occurs early in the MCS life cycle but then reduces in importance as the environment behind the convective line is moistened from the top down. Evaporation below the melting layer was insufficient to attain saturation below the melting layer at any time or location within the MCS TSRs. Relative humidity was found to have a strong correlation to the component of wind parallel to the storm motion, especially within air flowing from front to rear.
Low-Level Thermodynamic, Kinematic, and Reflectivity Fields of Hurricane Guillermo (1997) during Rapid Intensification
Authors: Sitkowski Matthew , Barnes Gary M. 
Published: August 2008

Abstract
From 0600 UTC 2 August to 1200 UTC 3 August Hurricane Guillermo (1997) deepened by 54 hPa over the eastern North Pacific Ocean, easily exceeding the thresholds that define rapid intensification (RI). The NOAA WP-3Ds observed a portion of this RI with similar two-aircraft missions on consecutive days. The aircraft jettisoned 70 successful global positioning system (GPS) dropwindsondes (or GPS sondes), which reveal how conditions in the lower troposphere on the octant to quadrant scale evolved within 250 km of the eye. Reflectivity fields demonstrate that the deepening is correlated with a spiraling in of the northern eyewall that reduces the eye diameter by 10 km. This behavior contrasts the more uniform contraction witnessed during eyewall replacement cycles. Mixing between the lower eye and eyewall, as detailed by other investigators, appears to have triggered the reduction in the eye diameter. After RI the eyewall remains asymmetrical with the tallest echo tops and heaviest rain rates located on the east or trailing side of the hurricane and to the left of the deep-layer shear vector. Net latent heat release within 60 km of the circulation center increases 21% from 2 to 3 August and is matched by a 30% increase in the inflow below 2 km at the 100-km radius. The GPS sondes, combined with aircraft in situ data for the eyewall region, reveal that the tropical cyclone (TC) establishes an annulus adjacent to and under the eyewall where the tangential wind component and equivalent potential temperature increase substantially. The radial extent of this annulus is constrained by the rainbands that remain robust throughout RI. The results support the argument that RI is controlled by processes within 100 km of the circulation center, and in particular within the eyewall.
Evaluation of Short-Range Quantitative Precipitation Forecasts from a Time-Lagged Multimodel Ensemble
Authors: Yuan Huiling , Lu Chungu , McGinley John A. , Schultz Paul J. , Jamison Brian D. , Wharton Linda , Anderson Christopher J. 
Published: August 2008

Abstract
Short-range quantitative precipitation forecasts (QPFs) and probabilistic QPFs (PQPFs) are investigated for a time-lagged multimodel ensemble forecast system. One of the advantages of such an ensemble forecast system is its low-cost generation of ensemble members. In conjunction with a frequently cycling data assimilation system using a diabatic initialization [such as the Local Analysis and Prediction System (LAPS)], the time-lagged multimodel ensemble system offers a particularly appealing approach for QPF and PQPF applications. Using the NCEP stage IV precipitation analyses for verification, 6-h QPFs and PQPFs from this system are assessed during the period of March–May 2005 over the west-central United States. The ensemble system was initialized by hourly LAPS runs at a horizontal resolution of 12 km using two mesoscale models, including the fifth-generation Pennsylvania State University–National Center for Atmospheric Research Mesoscale Model (MM5) and the Weather Research and Forecast (WRF) model with the Advanced Research WRF (ARW) dynamic core. The 6-h PQPFs from this system provide better performance than the NCEP operational North American Mesoscale (NAM) deterministic runs at 12-km resolution, even though individual members of the MM5 or WRF models perform comparatively worse than the NAM forecasts at higher thresholds and longer lead times. Recalibration was conducted to reduce the intensity errors in time-lagged members. In spite of large biases and spatial displacement errors in the MM5 and WRF forecasts, statistical verification of QPFs and PQPFs shows more skill at longer lead times by adding more members from earlier initialized forecast cycles. Combing the two models only reduced the forecast biases. The results suggest that further studies on time-lagged multimodel ensembles for operational forecasts are needed.
The Gridding of MOS
Authors: Glahn Bob , Gilbert Kathryn , Cosgrove Rebecca , Ruth David P. , Sheets Kari 
Published: August 2008

AbstractModel output statistics (MOS) guidance forecasts have been produced at stations and provided to National Weather Service forecasters and private entities for over three decades. As the numerical weather prediction models became more accurate, MOS followed that trend. Up until a few years ago, the MOS produced at observation locations met the basic need for guidance. With the advent of the Interactive Forecast Preparation System and the National Digital Forecast Database, gridded MOS forecasts became needed as guidance for forecasters. One method of providing such grids is to objectively analyze the MOS forecasts for points.A basic successive correction method has been extended to analyze MOS forecasts and surface weather variables. This method is being applied to MOS forecasts to provide guidance for producing grids of sensible weather elements such as temperature, clouds, and snow amount. Guidance forecasts have been implemented for the conterminous United States for most weather elements contained in routine weather forecasts. This paper describes the method applied to daytime maximum temperature over the conterminous United States and gives example results.
A decade of genome-wide gene expression profiling in acute myeloid leukemia: flashback and prospects
Authors: Wouters Bas J. , Löwenberg Bob , Delwel Ruud 
Published: August 2008

AbstractThe past decade has shown a marked increase in the use of high-throughput assays in clinical research into human cancer, including acute myeloid leukemia (AML). In particular, genome-wide gene expression profiling (GEP) using DNA microarrays has been extensively used for improved understanding of the diagnosis, prognosis, and pathobiology of this heterogeneous disease. This review discusses the progress that has been made, places the technologic limitations in perspective, and highlights promising future avenues
SBML-SAT: a systems biology markup language (SBML) based sensitivity analysis tool
Authors: Zi Zhike , Zheng Yanan , Rundell Ann E , Klipp Edda 
Published: August 2008

Abstract

Background
It has long been recognized that sensitivity analysis plays a key role in modeling and analyzing cellular and biochemical processes. Systems biology markup language (SBML) has become a well-known platform for coding and sharing mathematical models of such processes. However, current SBML compatible software tools are limited in their ability to perform global sensitivity analyses of these models.

Results
This work introduces a freely downloadable, software package, SBML-SAT, which implements algorithms for simulation, steady state analysis, robustness analysis and local and global sensitivity analysis for SBML models. This software tool extends current capabilities through its execution of global sensitivity analyses using multi-parametric sensitivity analysis, partial rank correlation coefficient, SOBOL's method, and weighted average of local sensitivity analyses in addition to its ability to handle systems with discontinuous events and intuitive graphical user interface.

Conclusion
SBML-SAT provides the community of systems biologists a new tool for the analysis of their SBML models of biochemical and cellular processes.
Targeted disruption of the mouse Csrp2gene encoding the cysteine- and glycine-rich LIM domain protein CRP2 result in subtle alteration of cardiac ultrastructure
Authors: Sagave Julia F , Moser Markus , Ehler Elisabeth , Weiskirchen Sabine , Stoll Doris , Günther Kalle , Büttner Reinhard , Weiskirchen Ralf 
Published: August 2008

Abstract

Background
The cysteine and glycine rich protein 2 (CRP2) encoded by the Csrp2 gene is a LIM domain protein expressed in the vascular system, particularly in smooth muscle cells. It exhibits a bimodal subcellular distribution, accumulating at actin-based filaments in the cytosol and in the nucleus. In order to analyze the function of CRP2 in vivo, we disrupted the Csrp2 gene in mice and analysed the resulting phenotype.

Results
A ~17.3 kbp fragment of the murine Csrp2 gene containing exon 3 through 6 was isolated. Using this construct we confirmed the recently determined chromosomal localization (Chromosome 10, best fit location between markers D10Mit203 proximal and D10Mit150 central). A gene disruption cassette was cloned into exon 4 and a mouse strain lacking functional Csrp2 was generated. Mice lacking CRP2 are viable and fertile and have no obvious deficits in reproduction and survival. However, detailed histological and electron microscopic studies reveal that CRP2-deficient mice have subtle alterations in their cardiac ultrastructure. In these mice, the cardiomyocytes display a slight increase in their thickness, indicating moderate hypertrophy at the cellular level. Although the expression of several intercalated disc-associated proteins such as β-catenin, N-RAP and connexin-43 were not affected in these mice, the distribution of respective proteins was changed within heart tissue.

Conclusion
We conclude that the lack of CRP2 is associated with alterations in cardiomyocyte thickness and hypertrophy.