bluuebunny/crossref_metadata_2025_split huggingface dataset:
OSW-1 triggers necroptosis in colorectal cancer cells through the RIPK1/RIPK3/MLKL signaling pathway facilitated by the RIPK1-p62/SQSTM1 complex
Authors: Wang Nan , Li Chao-Yang , Yao Teng-Fei , Kang Xiao-Dan , Guo Hui-Shu 
Published: April 2024

BACKGROUND
Necroptosis has emerged as a novel molecular pathway that can be targeted by chemotherapy agents in the treatment of cancer. OSW-1, which is derived from the bulbs of Ornithogalum saundersiae Baker, exerts a wide range of pharmacological effects.
AIM
To explore whether OSW-1 can induce necroptosis in colorectal cancer (CRC) cells, thereby expanding its range of clinical applications.
METHODS
We performed a sequence of functional experiments, including Cell Counting Kit-8 assays and flow cytometry analysis, to assess the inhibitory effect of OSW-1 on CRC cells. We utilized quantitative proteomics, employing tandem mass tag labeling combined with liquid chromatography-tandem mass spectrometry, to analyze changes in protein expression. Subsequent bioinformatic analysis was conducted to elucidate the biological processes associated with the identified proteins. Transmission electron microscopy (TEM) and immunofluorescence studies were also performed to examine the effects of OSW-1 on necroptosis. Finally, western blotting, siRNA experiments, and immunoprecipitation were employed to evaluate protein interactions within CRC cells.
RESULTS
The results revealed that OSW-1 exerted a strong inhibitory effect on CRC cells, and this effect was accompanied by a necroptosis-like morphology that was observable via TEM. OSW-1 was shown to trigger necroptosis via activation of the RIPK1/RIPK3/MLKL pathway. Furthermore, the accumulation of p62/SQSTM1 was shown to mediate OSW-1-induced necroptosis through its interaction with RIPK1.
CONCLUSION
We propose that OSW-1 can induce necroptosis through the RIPK1/RIPK3/MLKL signaling pathway, and that this effect is mediated by the RIPK1-p62/SQSTM1 complex, in CRC cells. These results provide a theoretical foundation for the use of OSW-1 in the clinical treatment of CRC.
Reviewing explore/exploit decision-making as a transdiagnostic target for psychosis, depression, and anxiety
Authors: Lloyd Alex , Roiser Jonathan P. , Skeen Sarah , Freeman Ze , Badalova Aygun , Agunbiade Adeola , Busakhwe Chuma , DeFlorio Carla , Marcu Anna , Pirie Heather , Saleh Romana , Snyder Theresa , Fearon Pasco , Viding Essi 
Published: April 2024

AbstractIn many everyday decisions, individuals choose between trialling something novel or something they know well. Deciding when to try a new option or stick with an option that is already known to you, known as the “explore/exploit” dilemma, is an important feature of cognition that characterises a range of decision-making contexts encountered by humans. Recent evidence has suggested preferences in explore/exploit biases are associated with psychopathology, although this has typically been examined within individual disorders. The current review examined whether explore/exploit decision-making represents a promising transdiagnostic target for psychosis, depression, and anxiety. A systematic search of academic databases was conducted, yielding a total of 29 studies. Studies examining psychosis were mostly consistent in showing that individuals with psychosis explored more compared with individuals without psychosis. The literature on anxiety and depression was more heterogenous; some studies found that anxiety and depression were associated with more exploration, whereas other studies demonstrated reduced exploration in anxiety and depression. However, examining a subset of studies that employed case-control methods, there was some evidence that both anxiety and depression also were associated with increased exploration. Due to the heterogeneity across the literature, we suggest that there is insufficient evidence to conclude whether explore/exploit decision-making is a transdiagnostic target for psychosis, depression, and anxiety. However, alongside our advisory groups of lived experience advisors, we suggest that this context of decision-making is a promising candidate that merits further investigation using well-powered, longitudinal designs. Such work also should examine whether biases in explore/exploit choices are amenable to intervention.
THEFT FROM "SOMEONE ELSE'S POCKET": QUALIFICATION PROBLEMS
Authors: Чернышев Дмитрий Борисович 
Published: April 2024

Введение: в статье рассматривается проблема квалификации кражи имущества из одежды, сумки или другой ручной клади, находившихся при лице, не являющемся собственником похищенного, то есть не подлежащим признанию потерпевшим. Материалы и методы: материалами явились вступившие в силу решения судов, научные исследования. Методологическую основу исследования составили методы системного анализа российского уголовного законодательства, анализ судебной практики. Результаты исследования: в ходе исследования автором рассмотрена проблема квалификации тайного хищения имущества у лица, не обладающего по отношению к имуществу классической триадой полномочий, образующих право собственности. Установлена проблема невозможности формального признания его потерпевшим согласно существующей редакции п. «г» ч. 2 ст. 158 УК РФ, что препятствует квалификации в соответствии с фактическими обстоятельствами совершенного преступления. Обсуждение и заключение: автором предложено внести изменения в диспозицию п. «г» ч. 2 ст. 158 УК РФ, изложив ее в следующей редакции: «кража, то есть тайное хищение чужого имущества, совершенная из одежды, сумки или другой ручной клади, находящихся при собственнике или ином владельце».
Introduction: the article discusses the difficulties in determining the theft of property from personal belongings such as clothes, bags, or hand luggage that were not owned by the victim. Materials and Methods: the study was based on court decisions that had come into force, as well as scientific studies. The methodological basis of the study was the systematic analysis of Russian criminal legislation and analysis of judicial practice. Results: the author researched the issue of qualifying hidden theft of property from a person who does not possess the classical triad of powers that constitute the right of ownership. It was found that paragraph “d” of Part 2 of Article 158 of the Criminal Code of the Russian Federation poses a problem of impossibility in formal recognition as a victim, which precludes qualification in accordance with the actual circumstances of the crime committed. Discussion and Conclusions: the author proposes an amendment to the disposition of paragraph “d” of Part 2 of Article 158 of the Criminal Code of the Russian Federation. The proposed amendment defines theft as the hidden theft of someone else's property from clothes, bags, or other hand luggage located with the owner or another owner.
THE THREAT OF MURDER OR SEVERE HARM TO HEALTH: GOAL SETTING FEATURES
Authors: Векленко Сергей Владимирович , Шутова Юлия Александровна 
Published: April 2024

Введение: статья посвящена исследованию цели совершения угрозы убийством или причинением тяжкого вреда здоровью. Материалы и методы: при написании статьи использовались результаты собственных эмпирических исследований. Применялись общенаучные и частнонаучные методы исследования, которые позволили проанализировать и обобщить собранные авторами относящиеся к предмету исследования материалы из различных источников. Обзор литературы: применялись труды отечественных ученых в области уголовного права, общей теории права, философии и психологии. Результаты исследования: авторами выявлена сущность цели-результата совершения угрозы убийством или причинением тяжкого вреда здоровью, использование которой отражает идею использования унифицированного понятийно-категориального аппарата в целях создания единообразной правоприменительной практики. Обсуждение и заключение: авторами сформулированы предложения, которые позволят правоприменителям единообразно понимать целеполагание при угрозе убийством или причинением тяжкого вреда здоровью. Обозначенные предложения направлены на повышение эффективности защиты личности от преступных посягательств на психическое и социальное здоровье.
Introduction: the article examines the threat of murder or severe harm to health. Materials and Methods: the authors conducted their own empirical study and used universal and special research methods to analyze and summarize materials from various sources. Literature Review: includes works by Russian criminal law, general theory of law, psychology, and philosophy scientists. Results: the authors have identified the essence of the 'goal-result' of the threat of murder or severe harm to health. Its usage reflects the idea of using a unified conceptual and categorical apparatus to create uniform law enforcement practices. Discussion and Conclusions: the authors provide suggestions to help enforcers understand the goal setting unambiguously concerning threatening to kill or cause serious harm to health.
THE INTERMEDIATE COURT OF APPEAL IN THE FORM OF JUDICIAL CONTROL IN THE RUSSIAN CRIMINAL PROCEEDINGS: GENESIS OF THE PROBLEM
Authors: Ибрагимова Алиса Мансуровна 
Published: April 2024

Введение: в статье раскрывается проблема межотраслевой конкуренции норм уголовно-процессуального законодательства и законодательства об административном судопроизводстве, посвященных обжалованию действий (бездействия) и решений участников уголовного судопроизводства, наделенных уголовно-процессуальными полномочиями, в порядке судебного контроля. Материалы и методы: эмпирическую базу исследования составили материалы прокурорско-следственной и судебной практики. Методологическую основу исследования составили общенаучный метод диалектики, а также такие частнонаучные методы познания, как системный, сравнительно-правовой, формально-юридический методы познания, индукция и дедукция. Результаты исследования: проведенное автором исследование позволило выявить противоречия в правовом регулировании между нормами уголовно-процессуального права и нормами об административном судопроизводстве, обосновать и предложить изменения в действующее законодательство, сформулировать понятие межотраслевого правового института обжалования в форме судебного контроля в уголовном судопроизводстве. Обсуждение и заключение: автором приводится теоретическое обоснование способов решения проблемы межотраслевых противоречий в рамках исследуемого института, а также предлагается внесение изменений в действующее законодательство, излагается авторская редакция некоторых положений статьи 1 Кодекса административного судопроизводства Российской Федерации.
Introduction: the article examines the issue of intersectoral competition between criminal procedural law and administrative procedural law. In particular, it focuses on the challenge to acts (or omissions) and decisions of participants in criminal proceedings who have criminal procedural powers, and the challenges that arise in the context of judicial review. Materials and Methods: the empirical basis of the study consists of prosecution and investigation materials as well as court records. The study was based on the universal scientific research method of dialectics, as well as specific research methods of cognition, including systemic, comparative and legal cognition, and the legal method of cognition, as well as induction and deduction. Results: the results revealed contradictions in the legal regulation between the norms of criminal procedure and the Administrative Procedure Act. The author has justified and proposed changes in the current law. The author defined the concept of an interbranch legal institution of appeal by way of judicial review in criminal proceedings. Discussion and Conclusions: the author provides a theoretical justification for addressing intersectoral contradictions within the studied institution. In addition, the author proposes amendments to the current legislation and outlines their version of certain provisions of Article 1 of the Code of Administrative Procedure of the Russian Federation.
Inertial Waves in a Nonlinear Simulation of the Sun's Convection Zone and Radiative Interior
Authors: Blume Catherine C. , Hindman Bradley W. , Matilsky Loren I. 
Published: April 2024

Abstract
Recent observations of Rossby waves and other more exotic forms of inertial oscillations in the Sun’s convection zone have kindled the hope that such waves might be used as a seismic probe of the Sun's interior. Here, we present a 3D numerical simulation in spherical geometry that models the Sun’s convection zone and upper radiative interior. This model features a wide variety of inertial oscillations, including both sectoral and tesseral equatorial Rossby waves, retrograde mixed inertial modes, prograde thermal Rossby waves, the recently observed high-frequency retrograde (HFR) vorticity modes, and what may be latitudinal overtones of these HFR modes. With this model, we demonstrate that sectoral and tesseral Rossby waves are ubiquitous within the radiative interior as well as within the convection zone. We suggest that there are two different Rossby-wave families in this simulation that live in different wave cavities: one in the radiative interior and one in the convection zone. Finally, we suggest that many of the retrograde inertial waves that appear in the convection zone, including the HFR modes, are in fact all related, being latitudinal overtones that are mixed modes with the prograde thermal Rossby waves.
High-cadence Timing of Binary Pulsars with CHIME
Authors: Tan Chia Min , Fonseca Emmanuel , Crowter Kathryn , Dong Fengqiu Adam , Kaspi Victoria M. , Masui Kiyoshi W. , McKee James W. , Meyers Bradley W. , Ransom Scott M. , Stairs Ingrid H. 
Published: April 2024

Abstract
We performed near-daily observations of the binary pulsars PSR J0218+4232, PSR J1518+4904, and PSR J2023+2853 with the Canadian Hydrogen Intensity Mapping Experiment (CHIME). For the first time, we detected the Shapiro time delay in all three pulsar binary systems, using only 2–4 yr of CHIME/Pulsar timing data. We measured the pulsar masses to be

1.49

−
0.20

+
0.23

M
⊙,

1.470

−
0.034

+
0.030

M
⊙, and

1.50

−
0.38

+
0.49

M
⊙, respectively. The companion mass to PSR J0218+4232 was found to be

0.179

−
0.016

+
0.018

M
⊙. We constrained the mass of the neutron star companion of PSR J1518+4904 to be

1.248

−
0.029

+
0.035

M
⊙, using the observed apsidal motion as a constraint on the mass estimation. The binary companion to PSR J2023+2853 was found to have a mass of

0.93

−
0.14

+
0.17

M
⊙; in the context of the near-circular orbit, this mass estimate suggests that the companion to PSR J2023+2853 is likely a high-mass white dwarf. By comparing the timing model obtained for PSR J0218+4232 with previous observations, we found a significant change in the observed orbital period of the system of

P

b

̇

=
0.14
(
2
)
×

10

−
12

; we determined that this variation arises from “Shklovskii acceleration” due to the relative motion of the binary system, and used this measurement to estimate a distance of d = (6.7 ± 1.0) kpc to PSR J0218+4232. This work demonstrates the capability of high-cadence observations, enabled by the CHIME/Pulsar system, to detect and refine general-relativistic effects of binary pulsars over short observing timescales.
Constraints on the Origins of the Galactic Neutrino Flux Detected by IceCube
Authors: Desai Abhishek , Vandenbroucke Justin , Anandagoda Samalka , Thwaites Jessie , Romfoe M. J. 
Published: April 2024

Abstract
Galactic and extragalactic objects in the Universe are sources of high-energy neutrinos that may contribute to the astrophysical neutrino signal seen by IceCube. Recently, a study done using cascade-like events seen by IceCube reported neutrino emission from the Galactic plane with >4σ significance. In this work, we put a lower limit on the number of Galactic sources required to explain this emission. To achieve this, we use a simulation package created to simulate point sources in the Galaxy along with the neutrino and gamma-ray flux emissions originating from them. Along with using past IceCube discovery potential curves, we also account for Eddington bias effects due to Poisson fluctuations in the number of detected neutrino events. We present a toy Monte Carlo simulation to show that there must be at least eight sources, each with luminosity less than 1.6 × 1035 erg s−1, responsible for the Galactic neutrino emission. Our results constrain the number of individual point-like emission regions, which apply both to discrete astrophysical sources and to individual points of diffuse emission.
Reconnaissance with JWST of the J-region Asymptotic Giant Branch in Distance Ladder Galaxies: From Irregular Luminosity Functions to Approximation of the Hubble Constant
Authors: Li Siyang , Riess Adam G. , Casertano Stefano , Anand Gagandeep S. , Scolnic Daniel M. , Yuan Wenlong , Breuval Louise , Huang Caroline D. 
Published: April 2024

Abstract
We study stars in the J-regions of the asymptotic giant branch (JAGB) of near-infrared color–magnitude diagrams in the maser host NGC 4258 and four hosts of six Type Ia supernovae (SNe Ia): NGC 1448, NGC 1559, NGC 5584, and NGC 5643. These clumps of stars are readily apparent near 1.0 < F150W − F277W < 1.5 and m
F150W = 22–25 mag with James Webb Space Telescope NIRCam photometry. Various methods have been proposed to assign an apparent reference magnitude to this recently proposed standard candle, including the mode, median, sigma-clipped mean, or a modeled luminosity function parameter. We test the consistency of these by measuring intrahost variations, finding differences of up to ∼0.2 mag that significantly exceed statistical uncertainties. Brightness differences appear intrinsic, and are further amplified by the nonuniform shape of the JAGB luminosity function, also apparent in the LMC and SMC. We follow a “many methods” approach to measure consistently JAGB magnitudes and distance moduli to the SN Ia host sample calibrated by NGC 4258. We find broad agreement with distance moduli measured from Cepheids, tip of the red giant branch, and Miras. However, the SN host mean distance modulus estimated via the JAGB method necessary to estimate H
0 differs by ∼0.19 mag among the above definitions, the result of different levels of luminosity function asymmetry. The methods yield a full range of 71−78 km s−1 Mpc−1, i.e., a fiducial result of H
0 = 74.7 ± 2.1(stat) ± 2.3(sys, ±3.1 if combined in quadrature) km s−1 Mpc−1, with systematic errors limited by the differences in methods. Future work may seek to standardize and refine this promising tool further, making it more competitive with established distance indicators.
Mapping the Chemodynamics of the Galactic Disk Using the LAMOST and APOGEE Red Clump Stars
Authors: Sun Weixiang , Shen Han , Jiang Biwei , Liu Xiaowei 
Published: April 2024

Abstract
A detailed measurement is made of the metallicity distributions, kinematics, and dynamics of the thin and thick disks across a large disk volume (5.0 ≤ R ≤ 15.0 kpc and ∣Z∣ ≤ 3.0 kpc) by using the LAMOST–APOGEE red clump stars. The metallicity distribution results show that the radial metallicity gradient Δ[Fe/H]/ΔR of the thin disk weakens with ∣Z∣ from −0.06 dex kpc−1 at around ∣Z∣ < 0.25 kpc to −0.02 dex kpc−1 at around ∣Z∣ > 2.75 kpc, while the thick disk displays a global weak positive Δ[Fe/H]/ΔR that is generally weaker than 0.01 dex kpc−1. The vertical metallicity gradient Δ[Fe/H]/Δ∣Z∣ steadily weakened from −0.36 dex kpc−1 at R ∼ 5.5 kpc to −0.05 dex kpc−1 at around R > 11.5 kpc for the thin disk, while the thick disk presents an almost constant value (nearly −0.06∼−0.08 dex kpc−1) for all the R bins. These results indicate the contribution of the radial migration to the disk evolution, and the obvious north–south asymmetry in [Fe/H] may be linked to disk warp and/or disk perturbation events. The oscillations in the corrected Δ[Fe/H]/Δ∣Z∣ with R likely arise from the resonances with the Galactic bar. Our detailed measurements of ΔV

ϕ
/Δ[Fe/H] indicate an inside-out and upside-down star formation scenario for the thick disk. The results of eccentricity distributions and [α/Fe]–velocity dispersion relations are likely to suggest that thick-disk stars require an obvious contribution from other heating mechanisms, such as mergers and accretion, or are born in the chaotic mergers of gas-rich systems and/or the turbulent interstellar medium.
Over 25 Years of Hope: Development of Lymphatic Filariasis Patient Support Groups in Haiti
Authors: Beau De Rochars Valery Madsen , Coreil Jeannine , Désir Martha , Mayard Gladys , Michel Marie Carmel , Milord Marie Denise , Carpenter Rand , Streit Thomas G. , Désir Luccène , Noland Gregory S. , Addiss David G. 
Published: April 2024

ABSTRACT.
Support groups can create environments that are conducive to healing and well-being, particularly for persons with stigmatizing chronic diseases. In 1998, the support group concept was adapted in Haiti for persons with disabling lymphedema caused by lymphatic filariasis (LF). The project was developed with the expectation that the support group model conceived in the developed world be interpreted and modified by persons affected with lymphedema in the Haitian setting. Initiated with modest financial support within a research initiative to eliminate LF, a total of 50 “Hope Clubs” were formed from 1998 to 2023 across seven communes (districts) located in 3 of Haiti’s 10 regional Departments. Documented benefits of the support groups included improved limb self-care, decreased incidence of inflammatory episodes (adenolymphangitis), enhanced self-efficacy, economic benefit through microenterprise, and improved quality of life. Despite challenges of funding shortfalls, natural disasters, and political insecurity, persistence of LF support groups in Haiti highlights the crucial role of group ownership by affected persons and the freedom to reinvent the support group concept in light of local social, cultural, and economic conditions.
PENDAMPINGAN PENYUSUNAN DOKUMEN PERENCANAAN PEMBANGUNAN SANITASI PADA MASA PANDEMI COVID-19
Authors: Rizani Mohammad Debby , Rahayu Teguh Imam , Dirman Eris Nur 
Published: April 2024

Abstract: Layanan sanitasi adalah salah satu bentuk pelayanan dasar yang wajib didapatkan oleh masyarakat. Dalam rangka mewujudkan peran pemerintah daerah untuk mengetahui capaian layanan sanitasi dan menentukan target layanan sanitasi layak dan aman, maka diperlukan penyusunan dokumen perencanaan pembangunan sanitasi. Kegiatan penyusunan dokumen tersebut menjadi tanggung jawab pemerintah daerah dalam mewujudukan pengelolaan sanitasi yang baik. Pada realita di daerah, dikarenakan masing-masing dinas mempunyai kegiatan rutin mengakibatkan proses penyusunan dokumen perencanaan pembangunan sanitasi tidak sesuai yang diharapkan. Oleh karena itu diperlukan pendampingan dalam penyusunan dokumen perencanaan pembangunan sanitasi dengan menggunakan pendekatan pembelajaran pada pemerintah daerah. Metode pembelajaran yang digunakan pada masa pandemi covid dengan melakukan pelatihan termoderasi. Pelatihan termoderasi merupakan metode dengan melibatkan pemateri dan fasilitator kelas dalam menyampaikan materi ajar pada peserta pelatihan melalui daring/luring. Tujuan pembelajaran di mulai dari tingkat pemahaman awal sampai dengan tingkat pemahaman yang mampu dicapai oleh peserta serta disusun sesuai substansi yang diajarkan, singat, jelas dan terukur. Upaya pencapaian tujuan dari pembelajaran secara optimal, perlu direncanakan dan ditentukan peserta sebagai target pelatihan, tujuan pembelajaran, ruang lingkup materi, kanal pelatihan (daring/luring), agenda pelatihan, serta pemateri dan fasilitator. Total alokasi waktu metode belajar dengan pelatihan termoderasi menjadi hal penting yang harus diperhatikan. Pelatihan termoderasi pada masa pandemi covid dengan perpaduan daring dan luring sangatlah efektif dalam proses tukar pengetahuan, pemahaman substansi materi dan dapat memotivasi dalam meningkatkan kapasitas peserta pelatihan, serta diharapkan pasca pelatihan, peserta dapat menyusun dokumen SSK yang berkualitas dan implementatif.