bluuebunny/crossref_metadata_2025_split huggingface dataset:
INFERENCE OF SCALE-FREE NETWORKS FROM GENE EXPRESSION TIME SERIES
Authors: DAISUKE TOMINAGA , HORTON PAUL 
Published: July 2006

Quantitative time-series observation of gene expression is becoming possible, for example by cell array technology. However, there are no practical methods with which to infer network structures using only observed time-series data. As most computational models of biological networks for continuous time-series data have a high degree of freedom, it is almost impossible to infer the correct structures. On the other hand, it has been reported that some kinds of biological networks, such as gene networks and metabolic pathways, may have scale-free properties. We hypothesize that the architecture of inferred biological network models can be restricted to scale-free networks. We developed an inference algorithm for biological networks using only time-series data by introducing such a restriction. We adopt the S-system as the network model, and a distributed genetic algorithm to optimize models to fit its simulated results to observed time series data. We have tested our algorithm on a case study (simulated data). We compared optimization under no restriction, which allows for a fully connected network, and under the restriction that the total number of links must equal that expected from a scale free network. The restriction reduced both false positive and false negative estimation of the links and also the differences between model simulation and the given time-series data.
EISENSTEIN LATTICES, GALOIS RINGS AND QUATERNARY CODES
Authors: GABORIT PHILIPPE , NATIVIDAD ANN MARIE , SOLÉ PATRICK 
Published: July 2006

Self-dual codes over the Galois ring GR(4,2) are investigated. Of special interest are quadratic double circulant codes. Euclidean self-dual (Type II) codes yield self-dual (Type II) ℤ4-codes by projection on a trace orthogonal basis. Hermitian self-dual codes also give self-dual ℤ4-codes by the cubic construction, as well as Eisenstein lattices by Construction A. Applying a suitable Gray map to self-dual codes over the ring gives formally self-dual 𝔽4-codes, most notably in length 12 and 24. Extremal unimodular lattices in dimension 38, 42 and the first extremal 3-modular lattice in dimension 44 are constructed.
An Electrophysiological Investigation of Preparatory Attentional Control in a Spatial Stroop Task
Authors: Stern Emily R. , Mangels Jennifer A. 
Published: July 2006

Abstract
Top-down attentional control is required when subjects must attend to one of multiple conflicting stimulus features, such as in the Stroop task. Performance may be improved when such control is implemented in advance of stimulus presentation, yet few studies have examined this issue. Our investigation employed a spatial Stroop task with a manual response, allowing us to focus on the effects of preparatory attention on verbal processing when it is the less automatic attribute. A letter cue (P or W) presented for 2200 msec instructed subjects to respond on the basis of the position or meaning of a word (up, down, left, right) placed in an incongruent position relative to center. Event-related potentials recorded during pre- and poststimulus periods were analyzed as a function of reaction time to the target stimulus (fast vs. slow) in order to differentiate neural activity associated with more or less successful implementation of control. During the prestimulus period, fast responses to subsequent targets were associated with enhanced slow-wave activity over right frontal and bilateral central-parietal regions. During the poststimulus period, fast word trials were uniquely associated with an enhanced inferior temporal negativity (ITN) from 200 to 600 msec. More importantly, a correlation between frontal prestimulus activity and the poststimulus ITN suggested that frontal preparatory activity played a role in facilitating conceptual processing of the verbal stimulus when it arrived, providing an important link between preparatory attention and mechanisms that improve performance in the face of conflict.
Performance Feedback Drives Caudate Activation in a Phonological Learning Task
Authors: Tricomi Elizabeth , Delgado Mauricio R. , McCandliss Bruce D. , McClelland James L. , Fiez Julie A. 
Published: July 2006

Abstract
Adults have difficulty discriminating nonnative phonetic contrasts, but under certain circumstances training can lead to improvement in this ability. Despite the ubiquitous use of performance feedback in training paradigms in this and many other domains, the mechanisms by which feedback affects learning are not well understood. In this event-related functional magnetic resonance imaging study, we examined how performance feedback is processed during perceptual learning. Thirteen Japanese speakers for whom the English phonemes [r] and [l] were nondistinct performed an identification task of the words “road” and “load” that has been shown to be effective in inducing learning only when performance feedback is present. Each subject performed alternating runs of training with and without feedback, followed by performance of a card-guessing task with monetary reward and punishment outcomes. We found that the caudate nucleus was more robustly activated bilaterally when performing the perceptual identification task with feedback than without feedback, and the right caudate nucleus also showed a differential response to positive and negative feedback. Moreover, using a within-subjects design, we found that the caudate nucleus also showed a similar activation pattern to monetary reward and punishment outcomes in the card-guessing task. These results demonstrate that the caudate responds to positive and negative feedback during learning in a manner analogous to its processing of extrinsic affective reinforcers and indicate that this region may be a critical moderator of the influence of feedback on learning. These findings impact our broader understanding of the mechanisms underlying nondeclarative learning and language acquisition.
Functional Specialization within Rostral Prefrontal Cortex (Area 10): A Meta-analysis
Authors: Gilbert Sam J. , Spengler Stephanie , Simons Jon S. , Steele J. Douglas , Lawrie Stephen M. , Frith Christopher D. , Burgess Paul W. 
Published: July 2006

AbstractOne of the least well understood regions of the human brain is rostral prefrontal cortex, approximating Brodmann's area 10. Here, we investigate the possibility that there are functional subdivisions within this region by conducting a meta-analysis of 104 functional neuroimaging studies (using positron emission tomography/functional magnetic resonance imaging). Studies involving working memory and episodic memory retrieval were disproportionately associated with lateral activations, whereas studies involving mentalizing (i.e., attending to one's own emotions and mental states or those of other agents) were disproportionately associated with medial activations. Functional variation was also observed along a rostral-caudal axis, with studies involving mentalizing yielding relatively caudal activations and studies involving multiple-task coordination yielding relatively rostral activations. A classification algorithm was trained to predict the task, given the coordinates of each activation peak. Performance was well above chance levels (74% for the three most common tasks; 45% across all eight tasks investigated) and generalized to data not included in the training set. These results point to considerable functional segregation within rostral prefrontal cortex.
Fractionating the Neural Mechanisms of Cognitive Control
Authors: Kopp Bruno , Tabeling Sandra , Moschner Carsten , Wessel Karl 
Published: July 2006

Abstract
Modifications of the Wisconsin Card Sorting Test were established. In these new task variants, participants were asked to exert sequential control over attentional sets or over intentional sets (task domain factor). Attentional set shifting requires changing the priorities by which sensory stimuli are selected, whereas intentional set shifting requires changing the priorities by which motor responses are selected. Auditory stimuli that signaled to maintain or shift set were presented immediately before (precuing) or after (postcuing) the selection of cards (cue timing factor). Twenty-four healthy young individuals participated. Performance data (response times, error percentages) indicated that intentional tasks were easier to perform than attentional tasks. The electroencephalogram was recorded during task performance, and the N1, medial frontal negativity (MFN), P3a, and sustained potential (SP) components of the cue event-related brain potentials (ERPs) were analyzed. Irrespective of the task domain, shift precues led to increased N1 amplitudes compared to shift postcues. When intentional sets had to be shifted, the MFNs in the postcuing condition were more pronounced than in the precuing condition. On the other hand, shifts of attentional sets resulted in a more prominent P3a in response to postcues compared to precues. Irrespective of the task domain, the shift effect that was evident in SPs was more pronounced in precue ERPs compared to postcue ERPs. We conclude that ERPs provide valid measures to empirically constrain theories about the neural mechanisms of cognitive control. The domain hypothesis of the fractionation of the neural mechanisms of cognitive control is introduced.
Common-onset Visual Masking in Infancy: Behavioral and Electrophysiological Evidence
Authors: Kotsoni Eleni , Mareschal Denis , Csibra Gergely , Johnson Mark H. 
Published: July 2006

Abstract
Common-onset visual masking (COVM) occurs when a mask and a target have common onset but delayed offset, with the mask persisting beyond the duration of the target [Di Lollo, V., Enns, J. T., & Rensink, R. A. Competition for consciousness among visual events: The psychophysics of reentrant visual events. Journal of Experimental Psychology: General, 129, 481–507, 2000]. We report the first behavioral and electrophysiological evidence of COVM in infants. An initial behavioral study included a familiarization phase during which a visual pattern (the target) surrounded by four black dots (the mask) was flashed 15 times to the infant. In the “unmasked” condition, the mask disappeared with the target. In the “masked” condition, the mask remained on the screen after deletion of the target for a further 93 msec. During the test phase, the familiar target pattern was paired with a new pattern. Infants in the unmasked condition showed a significant familiarity preference, suggesting that they had encoded the target during familiarization, whereas those in the masked condition showed no preference, suggesting that they had not encoded the target during familiarization. In the second experiment, high-density event-related potentials were used to investigate the electrophysiological pattern of activity that accompanies COVM. Six-month-old infants viewed both masked and unmasked conditions. Electrophysiological data indicated that over posterior channels the masked condition elicited a larger amplitude positive wave around 300 msec after stimulus onset than trials in the unmasked condition.
A Comparison of Abstract Rules in the Prefrontal Cortex, Premotor Cortex, Inferior Temporal Cortex, and Striatum
Authors: Muhammad Rahmat , Wallis Jonathan D. , Miller Earl K. 
Published: July 2006

Abstract
The ability to use abstract rules or principles allows behavior to generalize from specific circumstances. We have previously shown that such rules are encoded in the lateral prefrontal cortex (PFC) and premotor cortex (PMC). Here, we extend these investigations to two other areas directly connected with the PFC and the PMC, the inferior temporal cortex (ITC) and the dorsal striatum (STR). Monkeys were trained to use two abstract rules: “same” or “different”. They had to either hold or release a lever, depending on whether two successively presented pictures were the same or different, and depending on which rule was in effect. The rules and the behavioral responses were reflected most strongly and, on average, tended to be earlier in the PMC followed by the PFC and then the STR; few neurons in the ITC reflected the rules or the actions. By contrast, perceptual information (the identity of the pictures used as sample and test stimuli) was encoded more strongly and earlier in the ITC, followed by the PFC; they had weak, if any, effects on neural activity in the PMC and STR. These findings are discussed in the context of the anatomy and posited functions of these areas.
Relationship between Hippocampal Structure and Memory Function in Elderly Humans
Authors: Schiltz K. , Szentkuti A. , Guderian S. , Kaufmann J. , Münte T. F. , Heinze H. J. , Düzel E. 
Published: July 2006

AbstractWith progressing age, the ability to recollect personal events declines, whereas familiarity-based memory remains relatively intact. It has been hypothesized that age-related hippocampal atrophy may contribute to this pattern because of its critical role for recollection in younger humans and after acute injury. Here, we show that hippocampal volume loss in healthy older persons correlates with gray matter loss (estimated with voxel-based morphometry) of the entire limbic system and shows no correlation with an electrophysiological (event-related potential [ERP]) index of recollection. Instead, it covaries with more substantial and less specific electrophysiological changes of stimulus processing. Age-related changes in another complementary structural measure, hippocampal diffusion, on the other hand, seemed to be more regionally selective and showed the expected correlation with the ERP index of recollection. Thus, hippocampal atrophy in older persons accompanies limbic atrophy, and its functional impact on memory is more fundamental than merely affecting recollection.
Brain Basis of Developmental Change in Visuospatial Working Memory
Authors: Scherf K. Suzanne , Sweeney John A. , Luna Beatriz 
Published: July 2006

Abstract
Although brain changes associated with the acquisition of cognitive abilities in early childhood involve increasing localized specialization, little is known about the brain changes associated with the refinement of existing cognitive abilities that reach maturity in adolescence. The goal of this study was to investigate developmental changes in functional brain circuitry that support improvements in visuospatial working memory from childhood to adulthood. We tested thirty 8- to 47-year-olds in an oculomotor delayed response task. Developmental transitions in brain circuitry included both quantitative changes in the recruitment of necessary working memory regions and qualitative changes in the specific regions recruited into the functional working memory circuitry. Children recruited limited activation from core working memory regions (dorsal lateral prefrontal cortex [DLPFC] and parietal regions) and relied primarily on ventromedial regions (caudate nucleus and anterior insula). With adolescence emerged a more diffuse network (DLPFC, anterior cingulate, posterior parietal, anterior insula) that included the functional integration of premotor response preparation and execution circuitry. Finally, adults recruited the most specialized network of localized regions together with additional performance-enhancing regions, including left-lateralized DLPFC, ventrolateral prefrontal cortex, and supramarginal gyrus. These results suggest that the maturation of adult-level cognition involves a combination of increasing localization within necessary regions and their integration with performance-enhancing regions.
The Neural Correlates of Phonological Short-term Memory: A Repetitive Transcranial Magnetic Stimulation Study
Authors: Romero L. , Walsh V. , Papagno C. 
Published: July 2006

Abstract
Neuropsychological reports and activation studies by means of positron emission tomography and functional magnetic resonance imaging have suggested that the neural correlates of phonological short-term memory are located in the left hemisphere, with Brodmann's area (BA) 40 being responsible for short-term storage, and BA 44 for articulatory rehearsal. However, a careful review of the literature on the role of left BA 40 shows that the data are equivocal. We tested these hypotheses by means of repetitive transcranial magnetic stimulation (rTMS). Participants performed four tasks: two phonological judgements, thought to require only articulatory rehearsal without the contribution of short-term storage; a digit span, which involves both, short-term storage and articulatory rehearsal; and a pattern span, this last being the control task. The sites of stimulation were left BA 40, left BA 44 and the electrode location vtx, plus a baseline without TMS. Reaction times increased and accuracy decreased in the case of the phonological judgements and digit span after stimulation of both left sites, suggesting that BA 40, in addition to BA 44, is involved in phonological judgements. Possible explanations are discussed, namely, the possibility that (i) the neural correlates of rehearsal are not limited to BA 44 and (ii) phonological judgements involve processes other than rehearsal. We also consider the effects of using different tasks and responses to resolve some of the discrepancies in the literature.
Recent Developments in German Health Law
Authors: Hart Dieter 
Published: July 2006

AbstractHealth law provides the regulatory constitution for the medical and healthcare system. It covers individual medical treatment as well as public healthcare provision and is insofar medical law as well as social security law (statutory health insurance law). The medical and health sciences (public health sciences) are the main complementary disciplines of health law. This article gives an account of some representative developments in both fields which have taken place in the last three years.
Recent Developments in Health Law in Belgium
Authors: Nys Herman 
Published: July 2006

AbstractAfter the turbulent years 2002, 2003 and 2004 the Belgian health law seems to have reached calmer water. Indeed, after a quiet 2005, 2006 does not seem to have much to offer either. However, as will be shown in this article, this may be a wrong impression. There is a growing uneasiness with two important pieces of legislation that have been approved by Parliament in 2002: the act on euthanasia and the act on the rights of patients. This has resulted in debates and discussions that may finally lead to new legislation in the coming years.
Developments in Medical Law in the United Kingdom in 2005 and 2006
Authors: Harmon Shawn , Gertz Renate , Pradella Geoff , Laurie Graeme 
Published: July 2006

AbstractThis article highlights and summarises the key developments in medical law in the jurisdictions of the United Kingdom in 2005 and to April 2006. Topics are mental health and mental capacity, data protection, freedom of information and the impact on health data, the Human Tissue Act, genetic research databanks, Human Fertilisation and Embryology Act – Review of the legislation, consultations and related case law, developments in embryo and embryonic stem cell research, clinical trials and human subject research, medical futility, and physician assisted dying.
Decorrelation Scales of High-Resolution Turbulent Fluxes at the Ocean Surface and a Method to Fill in Gaps in Satellite Data Products
Authors: Romanou Anastasia , Rossow William B. , Chou Shu-Hsien 
Published: July 2006

Abstract
In the first part of the paper, a high space–time resolution (1° latitude/longitude and daily) dataset of the turbulent fluxes at the ocean surface is used to estimate and study the seasonal to annual near-global maps of the decorrelation scales of the latent and sensible heat fluxes. The decorrelation scales describe the temporal and spatial patterns that dominate the flux fields (within a bandpass window) and hence reveal the dominant variability in the air–sea interaction. Regional comparison to the decorrelation scales of the flux-related variables such as the wind stress, the humidity difference, and the SST identifies the main mechanism responsible for the variability in each flux field.
In the second part of the paper, the decorrelation scales are used to develop a method for filling missing values in the dataset that result from the incomplete satellite coverage. Weight coefficients in a linear regression function are determined from the spatial and temporal decorrelations and are functions of zonal and meridional distance and time. Therefore they account for all spatial and temporal patterns on scales greater than 1 day and 1° latitude/longitude and less than 1 yr and the ocean basin scale. The method is evaluated by simulating the missing-value distribution of the Goddard Satellite-Based Surface Turbulent Fluxes, version 2 (GSSTF2) dataset in the NCEP SST, the International Satellite Climatology Project (ISCCP)-FD (fluxes calculated using D1 series) surface radiation, and the Global Precipitation Climatology Project (GPCP) datasets and by comparing the filled datasets to the original ones. Main advantages of the method are that the decorrelation scales are unrestricted functions of space and time; only information internal to the flux field is used in the interpolation scheme, and the computation cost of the method is low enough to facilitate its use in similar large datasets.
Soluble triggering receptor expressed on myeloid cells-1 in acute respiratory infections
Authors: Phua J. , Koay E. S. C. , Zhang D. , Tai L. K. , Boo X. L. , Lim K. C. , Lim T. K. 
Published: July 2006

Levels of the soluble form of the triggering receptor expressed on myeloid cells (sTREM)-1 are elevated in severe sepsis. However, it is not known whether sTREM-1 measurements can distinguish milder bacterial infections from noninfectious inflammation. The present authors studied whether serum sTREM-1 levels differ in community-acquired pneumonia, exacerbations of chronic obstructive pulmonary disease (COPD), asthma and controls, and whether sTREM-1 may be used as a surrogate marker for the need for antibiotics.Serum sTREM-1 levels in 150 patients with pneumonia, COPD and asthma exacerbations and 62 healthy controls were measured.Serum sTREM-1 levels were significantly elevated in pneumonia (median 295.2 ng·mL-1), COPD (280.3 ng·mL-1) and asthma exacerbations (184.0 ng·mL-1) compared with controls (83.1 ng·mL-1). Levels were higher in pneumonia and Anthonisen type 1 COPD exacerbations than in type 2 and 3 COPD and asthma exacerbations. The area under the receiver operating characteristics curve for sTREM-1 as a surrogate marker for the need for antibiotics was 0.77.Serum levels of the soluble form of the triggering receptor expressed on myeloid cells-1 were elevated predominantly in pneumonia and Anthonisen type 1 COPD exacerbationsversustype 2 and 3 chronic obstructive pulmonary disease exacerbations, asthma and controls. Serum levels of the soluble form of the triggering receptor expressed on myeloid cells-1 has moderate but insufficient accuracy as a surrogate marker for the need for antibiotics in lower respiratory tract infections.