bluuebunny/crossref_metadata_2025_split huggingface dataset:
Flesh‐coloured micropapules on the face and upper trunk
Authors: Kossard Steven , Zagarella Sam 
Published: June 2007

SUMMARYThe following case report is of a 49 year old man who presented with a 20 year history of small asymptomatic flesh coloured firm papules which were concentrated on his face, neck and upper trunk. The diagnosis of multiple fibrofolliculomas of the familial type was reached.
Sweet's syndrome associated with Behçet's disease
Authors: Lee May‐Sen , Barnetson Ross St C 
Published: June 2007

SUMMARYA case of acute febrile neutrophilic dermatosis (Sweet's syndrome) associated with Behçet's disease occurring in a 48 year old woman is reported. She fulfilled the diagnostic criteria for both Sweet's syndrome and Behçet's disease. There have been several reports of this association. Herpes simplex virus was isolated from a genital ulcer in our patient. The possible role of herpes simplex virus in this interesting association of Behçet's disease and Sweet's syndrome is discussed and a review of the literature is made.
Scalp dermatitis, ectodermal dysplasia and cleft lip and palate: Rapp–Hodgkin or AEC syndrome
Authors: Rowan Darion M 
Published: June 2007

SUMMARYA female infant with ectodermal dysplasia, bilateral cleft lip and palate and a recalcitrant scalp dermatitis is presented. She had features of both Rapp–Hodgkin syndrome and AEC syndrome. It has recently been suggested in the literature that these two syndromes are the same condition and this case report supports this viewpoint.
Combination carbon dioxide laser vermilionectomy and wedge excision of the lip
Authors: Vinciullo Carl 
Published: June 2007

SUMMARYDermatologic surgeons are very familiar with the use of the carbon dioxide (CO2) laser for treating actinic cheilitis. When squamous cell carcinoma is proven or suspected in the affected lip, then combined CO2 laser vermilionectomy and wedge excision as a one stage procedure has significant advantages for the patient.
β‐1, 3‐D‐glucan gel in the treatment of solar keratoses
Authors: Tong David W , Barnetson Ross StC 
Published: June 2007

SUMMARYβ‐1, 3‐D‐glucans are yeast‐derived carbohydrate polymers which have been shown to be potent immunoresponse modulators which promote the regression of certain tumours. To date there is no published data concerning the efficacy of topical β‐1, 3‐D‐glucan in the treatment of solar keratoses. This randomized double‐blind prospective pilot study of 20 patients was performed to investigate the efficacy and skin tolerance of β‐1, 3‐D‐glucan gel versus placebo in the treatment of solar keratoses. The results of this study showed no significant benefit in using β‐1, 3‐D‐glucan gel over placebo in reducing counts of solar keratoses. No adverse effects were reported by any patient at any stage of the trial.
Acquired C1‐esterase inhibitor deficiency: Three case reports and commentary on the syndrome
Authors: Lipscombe TK , Orton DI , Bird AG , Wilkinson JD 
Published: June 2007

SUMMARYAcquired C1‐esterase inhibitor deficiency is a rare syndrome which usually presents with episodes of angioedema. Most patients have an underlying lymphoproliferative disorder. It is important to gastroenterologists, haematologists, immunologists and dermatologists, as these are the more likely specialties to which the patient will present. Recognition of the syndrome is important not only for diagnostic purposes but for investigating and treating any associated underlying lymphoproliferative disorders. In some instances the angioedema may precede the lymphoma by many years. Optimal patient management requires that both angioedema and the underlying lymphoma be recognized and treated.
Dressed to heal: New options for graft site dressing
Authors: Wilson Perry R 
Published: June 2007

SUMMARYTo ensure the close apposition and immobilization required for survival of full thickness skin grafts, the traditional method is to use pexing sutures or tie‐over pressure dressings.In certain areas, such as around the eye, other methods are required because either a concave or convex surface prevents adequate pressure, or the use of sutures as ties produces distortion of anatomical free margins.Alternative dressing methods include: telfa chips kept in place by a pressure pad; calcium alginate (which has the advantages of assisting haemostasis and absorbing serous discharge) under a pressure pad; and extra thin hydrocolloid dressings which decrease slough and are less conspicuous than other dressings.
Toxic epidermal necrolysis
Authors: Weightman Warren 
Published: June 2007

SUMMARYToxic epidermal necrolysis (TEN) is a rare, drug‐induced, life‐threatening syndrome with widespread epidermal loss and mucosal erosions. The classification, pathophysiology, clinical features and treatment are discussed in this review. Prognosis has improved as admission to a burns unit and early treatment of infection has become standard management. The role of corticosteroids in treatment is still controversial.
A pilot study on the percutaneous absorption of microfine titanium dioxide from sunscreens
Authors: Tan Mei‐Heng , Commens Chris A , Burnett Leslie , Snitch Peter J 
Published: June 2007

SUMMARYMany Australians are being advised to apply microfine titanium dioxide sunscreen daily from the cradle to the grave. However, there is a surprising lack of data on the percutaneous absorption of microfine titanium dioxide. A prospective pilot study was conducted to analyse the percutaneous absorption of microfine titanium dioxide from sunscreens. Selected patients scheduled to have skin surgery, applied titanium dioxide sunscreen to the skin daily for 2–6 weeks prior to their operation. After excision, the stratum corneum of the sample was stripped and the titanium concentration of the remaining epidermis and dermis was measured by inductively coupled plasma‐mass spectrometry. The results from this pilot study showed that levels of titanium in the epidermis and dermis of subjects who applied microfine titanium dioxide to their skin were higher than the levels of titanium found in controls. Studies with larger cohorts are necessary to establish if this absorption is statistically significant.
A comparative immunohistochemical study of lichen planus and discoid lupus erythematosus
Authors: Lee May‐Sen , Wilkinson Barbara , Doyle John A , Kossard Steven 
Published: June 2007

SUMMARYA comparative immunohistochemical study was performed on skin biopsies from 10 patients with lichen planus and 10 patients with discoid lupus erythematosus (DLE). A panel of antibodies against T lymphocytes (UCHL‐1, OPD‐4, CD8, CD45), B lymphocytes (L‐26), granulocytes (Leu‐M1), activation markers (Ki‐1, LN‐3), macrophages, fibroblasts and dendritic cells (FXIIIa, S‐100, Mac‐387, K.P‐1, vimentin), endothelial cells (CD34), and epithelial cells (epithelial membrane antigen) was employed using a peroxidase‐anti‐peroxidase technique. The recently released CD8 antiserum required microwave antigen retrieval of formalin‐fixed, paraffin‐embedded tissue to label lymphocytes. The results showed many similarities in the lymphocyte subsets and macrophages between lichen planus and discoid lupus erythematosus. The most important differences between the two conditions were statistically significant increases in the number of S‐100+ cells in the epidermis and dermis, FXIIIa+ cells in the dermis and CD34+ vessels within the inflammatory infiltrate in lichen planus.
Subcutaneous granuloma annulare in a patient with rheumatoid arthritis and diabetes mellitus
Authors: Tam Mei Mui , Meehan Cornelius J 
Published: June 2007

SUMMARYA case is reported of multiple subcutaneous nodules over the forehead and scalp of a 67‐year‐old male with moderately severe seropositive rheumatoid arthritis and corticosteroid‐induced diabetes mellitus. The histology was initially reported as consistent with a rheumatoid nodule, but on review, was regarded as typical of subcutaneous granuloma annulare (SCGA). The nodules resolved spontaneously within 4 months, which is also in keeping with SCGA. A brief review of the relevant literature is presented.
Human T lymphotropic virus‐1 infection
Authors: Kanzaki Tamotsu , Setoyama Mitsuru , Katahira Yoshihiko 
Published: June 2007

SUMMARYHuman T lymphotropic virus‐1 (HTLV‐1) is a retrovirus which infects T lymphocytes (CD4+) to cause adult T cell leukaemia/lymphoma (ATL), tropical spastic paraparesis and several other HTLV‐1 associated disorders. ATL has been reported worldwide but areas of high incidence include Japan (particularly the south‐west), Central and South America, northern Iran, West and Central Africa and Melanesia. In the general Japanese population, HTLV‐1 carriage is 0.1% but this can be as high as 30% in endemic areas. Six per 10000 carriers are estimated to progress to ATL each year. The three major routes of infection are mother to baby through breastfeeding, sexual intercourse and blood transfusion. There is a lengthy latency period of up to 40 years before the development of ATL. Up to 50% of ATL patients present with a cutaneous eruption. Diagnosis is established by the detection in lymphocytes of monoclonal integration of HTLV‐1 proviral DNA. Even with aggressive treatment, ATL patients generally have a poor prognosis.
Treatment of B cell lymphoma of the skin
Authors: Kikuchi Arata 
Published: June 2007

SUMMARYTen patients with B cell lymphoma of the skin have been treated in a 5 year period at the Keio University Hospital, Tokyo. Most present with an asymptomatic solitary nodule or multiple tumours of the skin but limitation to the skin is rare. Histopathology showed medium to large lymphoid cells in the dermis and subcutis. Radiotherapy was given for cutaneous lesions in conjunction with chemotherapy if there were metastases.
The frequency and nature of skin conditions seen in a private dermatology practice in Central Victoria, 1991–95
Authors: Kilkenny Monique F , Marks Robin 
Published: June 2007

SUMMARYA dermatology diagnostic database was established in order to determine the frequency and nature of skin conditions in a private dermatological practice in Central Victoria, Australia. Between August 1991 and June 1995, a total of 3346 dermatological diagnoses were recorded for 3000 new patient presentations.More women (58.9%) were seen than men (41.1%). Dermatitis and tumours of the skin accounted for 50% of new consultation(s), the highest attendance being for solar keratoses (11.9%). The frequency of patients seen was comparable to the previous 1970s survey of private dermatological practice in Australia, with the exception of melanocytic naevi, which was seen with twice the frequency compared to previously.The proportion of patients presenting with dermatitis was higher in the colder seasons of the year (winter and spring compared with summer and autumn). The proportion of people seen with melanocytic naevi was higher in summer and autumn compared with winter and spring.These results illustrate the usefulness of recording clinical patient data in practice as a way of recording patterns of referral as well as having a role in determining causation of disease.
Pulsed dye laser treatment of spider telangiectasia
Authors: Tan Ernest , Vinciullo Carl 
Published: June 2007

SUMMARYSpider telangiectasia is a common benign vascular malformation which can be a source of cosmetic concern for the patient A retrospective review of 30 adults and children with spider telangiectasia treated by the flashlamp‐pumped pulsed dye laser was undertaken. There was complete clearance of treated spider telangiectasia in 93% of patients after a single treatment There were no reported permanent adverse effects with purpura being the only transient problem. Most patients were satisfied with the eventual results of treatment and would recommend treatment to other people with a similar problem. This laser should be considered as the treatment of choice for spider telangiectasia.
Hypomelanosis of Ito: A syndrome requiring a multisystem approach
Authors: Failla Pinella , Romano Corrado , Schepis Carmelo 
Published: June 2007

SUMMARYHypomelanosis of Ito can be defined as a syndrome providing a cutaneous epiphenomenon with a peculiar pattern of distribution, usually associated with disorders of the nervous system, skeleton and eyes. Four further patients are reported and the literature reviewed. The diagnostic criteria and the differences with other pigmentary diseases distributed along Blaschko's lines are highlighted. The main histopathological features are reported and the high frequency of the associated abnormalities are emphasized. The chromosomal findings and main genetic hypotheses are discussed. The suggested follow‐up aims not only at the knowledge of the natural history of this condition, but also at its better delineation.
An organic refrigerant for cryosurgery: Fact or fiction?
Authors: Gaspar Zoran S , Dawber Rodney PR 
Published: June 2007

SUMMARYDimethylether/propane is an organic substance used as a refrigerant in a new cryodelivery system marketed for the treatment of warts. The objective was first to determine the temperatures achieved by mis delivery system, both at the end of the applicator and in the tissues and, second, to compare with liquid nitrogen delivered via standard cryospray equipment (CryAC). Temperature probes were used to measure temperatures 1 mm below the epidermis of pig trotters after freezing with the two delivery systems for 20 and 40 s. After freezing with dimethylether/propane, results showed tissue temperatures were 3°C at 20 s and 0°C at 40 s. Freezing with liquid nitrogen achieved −20°C at 20 s and −57°C at 40 s. It was concluded that dimethylether/ propane does not achieve tissue temperatures below 0°C and is not recommended in the use of malignant or premalignant lesions.
Cutaneous vascular response to calcitonin gene‐related peptide in psoriasis and normal subjects
Authors: Artemi Phillip , Seale Paul , Satchell Paul , Ware Sandra 
Published: June 2007

SUMMARYTo determine whether cutaneous blood vessels in subjects with psoriasis possess a generalized inherently abnormal response to neuropeptides, the effect of three doses of intradermally injected calcitonin gene‐related peptide (CGRP) on skin blood flow in normal subjects (n= 10), and on clinically normal skin (greater than 5 cm from psoriatic lesions) in subjects with psoriasis (n= 9) was measured using a laser Doppler technique. Calcitonin gene‐related peptide caused a dose‐dependent increase in local blood flow in both psoriatic and normal subjects, which was not statistically different between the two groups. This study has shown that the cutaneous vasculature at sites distant from lesions of psoriasis (> 5 cm) is not inherently different from normal skin in its response to CGRP.
Allergic contact dermatitis to multiple sawdust allergens
Authors: Cook David K , Freeman Susanne 
Published: June 2007

SUMMARYA 73‐year‐old man presented with an 8‐year history of a dermatitis affecting his face, dorsum of hands, and forearms. He was a retired cabinet maker but still carried out some timber work at home. He was patch tested and found to be positive to colophony and sawdust samples from four different timbers: Silky Oak, Queensland Hoop Pine, Radiata Pine and Australian red cedar.
Necrotizing cutaneous infection caused by Curvularia brachyspora in an immunocompetent host
Authors: Torda Adrienne J , Jones Philip D 
Published: June 2007

SUMMARYA case of necrotizing cutaneous infection in an immunocompetent host caused by the dematiaceous fungus, Curvularia brachyspora is presented. A 58‐year‐old man was transferred to the Prince Henry Hospital for treatment of necrotizing cellulitis involving both thighs that developed following cryotherapy. The patient did not respond to antibacterial therapy and hyperbaric oxygen. He was empirically commenced on intravenous amphotericin B and began to respond even before the pathogen C. brachyspora was identified.
Tinea due to Trichophyton violaceum in Victoria, Australia
Authors: Maslen Mary M , Andrew Peter J 
Published: June 2007

SUMMARYFrom 1963 to 1995, twenty isolates of Trichophyton violaceum from cases of tinea capitis and tinea corporis were referred to the Mycology Reference Laboratory of the Microbiological Diagnostic Unit at The University of Melbourne (Parkville, Victoria, Australia). The patients had presented at clinics in metropolitan Melbourne and country towns in the state of Victoria, Australia. Most patients were immigrants from the Mediterranean region or were Australian Aborigines. The most recent isolates of T. violaceum came from Ethiopian immigrants. Details of these twenty case histories are presented. The changing global distribution of infections due to T. violaceum is noted. The literature recording infections due to T. violaceum in Australia is reviewed.
Allergic contact dermatitis to plants: An analysis of 68 patients tested at the Skin and Cancer Foundation
Authors: Cook David K , Freeman Susanne 
Published: June 2007

SUMMARYAllergic contact dermatitis to plant allergens is a common problem in Australia. We present the cumulative experience of the Contact Dermatitis Clinic of the Skin and Cancer Foundation (Darlinghurst, NSW, Australia) a tertiary referral clinic. Results from a series of 68 patients with positive patch tests to 88 plant allergens are reported. We found that Grevillea species, Compositae, Rhus, Alstroemeria and various timber sawdusts were the most common plant allergens.
Successful use of ivermectin in the treatment of endemic scabies in a nursing home
Authors: Sullivan John R , Watt Geoffrey , Barker Brent 
Published: June 2007

SUMMARYIvermectin, an antiparasitic agent, was successfully used as a sole agent to combat endemic scabies in a closed 33‐bed ward of a rural nursing home. Previous topical therapies, including multiple applications of permethrin, ‐γ‐benzene hexachloride, benzyl benzoate and precipitated sulfur in white soft paraffin, had failed. Several patients exhibited hyperkeratotic crusted scabies with head and neck involvement and all residents except one recently arrived resident had evidence of active infestation. All residents were treated with 200 μg/kg of ivermectin and this dose was repeated 2 weeks later in all subjects. Four weeks after the first dose of ivermectin there was no evidence of active scabies and all rashes were totally resolved by 6 weeks. The action of ivermectin, its safety and its indications are discussed.
Allergic contact dermatitis to adhesive tape and contrived disease
Authors: Dwyer Phillip , Freeman Susanne 
Published: June 2007

SUMMARYA case of allergic contact dermatitis, caused by colophony in an orthopaedic tape, is presented. This failed to heal, despite removal of the allergen. Only after a period of observation in hospital and, finally, gentle confrontation with the patient, did it become clear that the perpetuation of the dermatitis was an example of contrived disease.
Lichenoid reaction to hepatitis B vaccination
Authors: Saywell Christina A , Wittal Richard A , Kossard Steven 
Published: June 2007

SUMMARYLiver disease is now a well recognized association with lichen planus. Recent reports suggest that the hepatitis viruses may play a central role in this association. The present report describes a case of a lichenoid reaction to hepatitis B vaccination, which has only been rarely documented previously. A 16‐year‐old male developed a widespread pruritic erythematous eruption 5 weeks after receiving his second dose of hepatitis B vaccine. The eruption evolved to produce strikingly blue macules before spontaneously disappearing. A skin biopsy showed an intense lichenoid reaction. The hepatitis B surface antigen component of the vaccine is probably responsible for this reaction as well as for other rare immunologically mediated reactions to hepatitis B vaccination. These reactions may provide insight into the pathogenesis of the cutaneous features of natural hepatitis B infection.
Extensive vesiculobullous eruption following limited ruby laser treatment for incontinentia pigmenti: A case report
Authors: Nagase Takashi , Takanashi Masanori , Takada Hiroko , Ohmori Kitaro 
Published: June 2007

SUMMARYA 3‐year‐old girl with incontinentia pigmenti was referred for treatment of pigmented whorled macules on the trunk and limbs. Initially ruby laser therapy was only given to the legs. Wound healing was delayed. Two months later the patient developed extensive vesicles and erosions restricted to pigmented macules in both treated and untreated areas. Conservative treatment, including 2 weeks hospitalization, improved acute inflammation, but the remaining pigmentation was darker than originally seen. The apparent reappearance of an early cutaneous manifestation of this syndrome, seemingly triggered by laser therapy, would suggest such treatment is contraindicated.
Pruritic follicular facial rash: Eosinophilic folliculitis
Authors: Kossard Steven , Saywell Laura 
Published: June 2007

SUMMARYThe authors describe a 30‐year‐old woman who over 2 years had a persistent papulopustular follicular eruption on the face. Skin biopsy showed eosinophilic folliculitis and there was a rapid response to indomethacin.
Serum and blister fluid cytokines and complement proteins in a patient with Henoch Schönlein purpura associated with a bullous skin rash
Authors: Bansal Amolak S , Dwivedi Naveen , Adsett Michael 
Published: June 2007

SUMMARYA case is presented of an adult with Henoch Schönlein purpura (HSP) with widespread bullous skin lesions in whom serum and bullous fluid (BF) cytokines and complement proteins were analysed. In both serum and BF the total haemolytic complement was subnormal. Soluble CD23 (sCD23), which is important in B cell activation and proliferation, was over 13 times higher in the BF compared with serum. The serum and BF levels of interleukin (IL) 1, IL6, IL10, tumour necrosis factor α and interferon γ were within the normal serum range of 30 healthy control subjects simultaneously analysed. The raised levels of sCD23 in BF suggest dysregulated humoral immunity in the cutaneous lesions of HSP.
Caterpillar dermatitis
Authors: Dunlop Katharine , Freeman Susanne 
Published: June 2007

SUMMARYA 3‐year‐old girl presented with recurrent urticarial eruptions presumed due to infestation of her garden with Euproctis edwardsi. Euproctis edwardsi, the mistletoe browntail moth, is a variety of hairy caterpillar widely distributed in south‐eastern Australia. They are often called‘woolly bears’by children. These caterpillars possess barbed hairs that fragment readily and are difficult to extract from the skin in one piece. Itching, urticarial wheals and papular eruptions can follow contact with the caterpillars or their detached hairs. The hairlets may be identified by microscopy from skin scrapings and can be removed by tape stripping or with the aid of fine forceps. The skin lesions are treated symptomatically with calamine lotion, sodium bicarbonate solution and antihistamines. Infestation with Euproctis edwardsi can be minimized by removal of mistletoe from eucalyptus trees and by spraying affected areas with white oil or carbaryl 0.1%.
Generalized pustular psoriasis responsive to PUVA and oral cyclosporin therapy
Authors: Hunt Michelle J , Lee Simon H , Salisbury Elizabeth LC , Wills Edward J , Armati Richard 
Published: June 2007

SUMMARYA patient with acute generalized pustular psoriasis was successfully treated with a combination of oral cyclosporin (6 mg/kg per day) and photochemotherapy (PUVA). Although early inpatient treatment with weak topical steroids and PUVA produced initial improvement, the patient's clinical condition fluctuated, with the subsequent development of erythroderma. The addition of oral cyclosporin produced dramatic improvement within 1 week of its commencement. The patient remained in remission 12 months following cessation of therapy.