bluuebunny/crossref_metadata_2025_split huggingface dataset:
TAMs-derived exosomal Meg8 promotes the EMT and metastasis of SACC by regulating EGFR through sponge absorption of miR-148a-3p
Authors: Gao Wanpeng , Wang Jiale , Shi Mingrui , Zhao Qi , Li Huan , Wang Jun , Huang Junhong , Ren Chenghao , Wei Jianhua , Yang Zihui , Yang Xinjie 
Published: April 2024

Abstract

Tumor-associated macrophages (TAMs) infiltrate extensively in salivary adenoid cystic carcinoma (SACC) tissues. Our previous study found that TAMs were significantly associated with the tumor metastasis and poor patients’ prognosis. However, the role and molecular mechanism of TAMs in SACC metastasis are still to be elucidated. Present study found that TAMs-derived exosomes can be internalized by SACC cells, initiating the epithelial-mesenchymal transition (EMT) process of SACC cells. TAMs-derived exosomal RNA sequencing and metastasis-related SACC tissues RNA sequencing suggested that Lnc-Meg8 was involved in TAMs-SACC interaction. RNA fluorescent in situ hybridization, RNA immunoprecipitation, and other in vitro assays revealed that TAMs-derived exosomes transferred Lnc-Meg8 to SACC cells, which promoted EGFR expression via sponge absorption of miR-148a-3p, thus promoting the EMT process of SACC cells. In vivo fluorescence imaging and immunohistochemical staining confirmed that inhibition of TAMs-derived exosomal Meg8 significantly improved the therapeutic efficacy of EGFR inhibitor cetuximab on the EMT and metastasis of SACC cells. In summary, our results demonstrated that the TAMs-derived exosomes promoted the EMT process of SACC cells via the Lnc-Meg8/miR-148a-3p/EGFR molecular axis. Blocking exosomal Lnc-Meg8 of TAMs may be a potential therapeutic strategy for SACC.
An Epic Advancement in Targeting Macrophages for Cancer Therapy
Approach
Authors: Xiaohong Lu , Qiuxia Fu , Ruie Li , Daijie Wang , Muluh Tobias Achu , Zhang Yan 
Published: April 2024

Abstract:
Macrophages are immune cells with high heterogeneity and plasticity, crucial for recognizing
and eliminating foreign substances, including cancer cells. However, cancer cells can evade
the immune system by producing signals that cause macrophages to switch to a pro-tumor phenotype,
promoting tumor growth and progression. Tumor-associated macrophages, which infiltrate
into tumor tissue, are important immune cells in the tumor microenvironment and can regulate cancer's
growth, invasion, and metastasis by inhibiting tumor immunity. This review article highlights
the characteristics of tumor-associated macrophages and their role in the occurrence and development
of cancer. It outlines how reprogramming macrophages towards an anti-tumor phenotype
can improve the response to cancer therapy. Explore the intricate process of engineered nanoparticles
serving as carriers for immunostimulatory molecules, activating macrophages to instigate
an anti-tumor response. Finally, it summarizes several studies demonstrating targeting
macrophages is a potential in preclinical cancer models. Several challenges must be addressed in
developing effective macrophage-targeted therapies, such as the heterogeneity of macrophage subtypes
and their plasticity. Further research is needed to understand the mechanisms underlying
macrophage function in the tumor microenvironment and identify novel targets for macrophage-directed
therapies. Targeting macrophages is a promising and innovative approach to improving cancer
therapy and patient outcomes.
Prominent Perspective on Existing Biological Hallmarks of Alzheimer’s Disease
Authors: Singh Namrata , Sharma Srishti , Ghosh Kallol K. , Gupta Bhanushree , Kuca Kamil 
Published: April 2024

Abstract::
Biomarkers are the most significant diagnosis tools tending towards unique approaches
and solutions for the prevention and cure of Alzheimer’s Disease (AD). The current report provides
a clear perception of the concept of various biomarkers and their prominent features through
analysis to provide a possible solution for the inhibition of events in AD. Scientists around the
world truly believe that crucial hallmarks can serve as critical tools in the early diagnosis, cure,
and prevention, as well as the future of medicine. The awareness and understanding of such biomarkers
would provide solutions to the puzzled mechanism of this neuronal disorder. Some of the
argued biomarkers in the present article are still in an experimental phase as they need to undergo
specific clinical trials before they can be considered for treatment.
An Innovative Retrofit Design for Energy Efficiency and Emission
Reduction: MAN B&W Marine Engine Slide Fuel Injector
Authors: Li Feifei , Dang Kun , Dong Shiwen 
Published: April 2024

Background::
The fuel injector is one of the most essential parts in marine diesel engines.
For MAN B&W two-stroke engines, the conventional fuel injector, due to the existence of sac volume,
can result in problems such as increased emission and fuel consumption and shortened service
life of combustion chamber components.

Objective::
The MAN B&W marine engine slide-type fuel injector is a structural retrofit of conventional
injectors, improving diesel engine combustion conditions, fuel efficiency, and emission reduction
in hydrocarbon, NOx, smoke, and particulate matter by eliminating sac volume with patented
technology.

Methods::
This study employed a comparative analysis approach to evaluate the performance of
conventional fuel injectors versus slide-type fuel injectors in MAN B&W two-stroke engines. Data
collection involved practical experiences, onboard operations, and analysis of fuel efficiency, emission
reduction, and combustion improvement. The structural differences and operational advantages
of both injector types were examined to assess the environmental benefits and economic implications
of adopting slide fuel injectors. Recommendations for the gradual replacement of conventional
injectors with slide-type injectors were based on empirical data and industry best practices.

Results::
Slide fuel injectors obtain a reduction of about 75% of the HC emissions at all loads. The
slide fuel injector significantly decreases the smoke emission level at low engine load, at 25% load.
A reduction in PM of up to 50% has been confirmed, and slide fuel injectors can reduce NOx emission
by approximately 15% on average.

result:
The smoke emission level at low engine load, at 25% load in particular, is greatly decreased by slide fuel injector.

Conclusion::
Slide fuel injectors, with a granted patent, are commonly used in marine low-speed
engines due to their advantages.
Towards Effective Measures for Curbing the Illegal Wildlife Trade: A Comprehensive Approach with ARIMA Modeling and Responsible Party Evaluation
Authors: Sun Haiyang , Song Xinjun , Zhang Tianze 
Published: April 2024

Illegal wildlife trade has become an urgent global problem that threatens global ecosystems, biodiversity and sustainable development. This problem requires us to propose comprehensive measures to significantly curb illegal wildlife trade.We used data from government work reports from 2014 to 2023 to establish an evaluation system for the responsible parties, and found that wildlife conservation is very important to the Chinese government using the AHP-Entropy weight method. We developed relevant measures to reduce illegal wildlife trade based on Citespace's literature research method. Then we collected public data from Chinese governmental departments from 2010 to 2023, and used ARIMA model to predict the future of the initiatives we developed to reduce illegal wildlife trade. By collecting public data from the China Wildlife Wildlife Enforcement Agency and fitting the state of wildlife conservation based on China's national conditions over the past 15 years, we evaluated the available resources and found that while the overall trend of the Chinese government can reduce illegal trade practices, the trend is not stable in the short term. China's wildlife protection agencies can continue to increase enforcement of this problem to better reduce the occurrence of illegal wildlife trade behavior.
Pedagogical design as a way to enhance the learning process
Authors: Гришаева Анна Валериевна 
Published: April 2024

В статье рассматриваются важнейшие направления развития образования в России, особенности и степени цифровизации образования, их влияние на трансформацию процесса обучения. Ставится вопрос о поиске новых способов организации педагогической практики. Дано определение педагогического дизайна как инновационного способа проектирования образовательных программ и курсов. Описаны особенности педагогического дизайна, на которые следует обратить внимание разработчикам программ и курсов. Перечислены основные модели педагогического дизайна, базовые принципы и преимущества педагогического дизайна в контексте современной парадигмы образования и при разработке конкурентоспособных образовательных программ и курсов. Раскрыт потенциал педагогического дизайна для повышения качества обучения в современных условиях цифровизации учебного процесса, анализ учебных активностей обучающихся и их сочетания при построении учебного курса.
The use of new digital tools in education requires a revision of pedagogical approaches and developing of new academic programs. The article discusses the most important direction of Russian education, its features and degrees of digitalization to transform learning process. The raised question is about finding new ways of organizing pedagogical practice. One of these ways is pedagogical design that allows creating educational products to improve the quality. The author analyzes the experience of using pedagogical design in Russian and foreign universities. The definition if classified as a process, a branch of scientific knowledge and technology by various authors in the pedagogical literature. The author deduces the definition of pedagogical design as an innovative way to design educational programs and courses. The lists of model and features are emphasizes to be paid attention to by the developers of programs and courses. In addition, the article notes the basic principles for creating competitive educational programs and courses in the context of the modern educational paradigm. The potential of pedagogical design is revealed in modern conditions of educational digitalization. An analysis is made of the students’ learning activities, corresponding to the nine steps of R. Gagne’s learning and their combinations when building a training course. Examples are given on the material of the training course “Foreign Language” for students majoring in Law. In conclusion the author highlights the role of pedagogical design as a major factor to organize successful teaching and learning.
The specifics of avoiding behavior of students in various situations
Authors: Годунов Михаил Викторович , Ахмедова Сабина Нютвели Кызы , Портнов Евгений Александрович 
Published: April 2024

Целью статьи является представление результатов исследования стратегии избегания как совладающего поведения, как способа урегулирования конфликтов, как модели принятия решений. В батарею тестов включены тест Дж. Амирхана выявления доминирующих копинг-стратегий, тест Томаса – Килманна предрасположенности к конфликтному поведению, Мельбурнский опросник принятия решений, методика Д. А. Леонтьева «Смысложизненные ориентации». Объем выборки 70 человек. Тестирование проводилось одновременно среди двух групп юношей-студентов, получающих юридическое образование: 18-летние студенты 1–2-го курсов (34 человека) и 22-летние студенты 4–5-го курсов (36 человек). Установлено, что 22-летние юноши-студенты более склонны к избеганию стрессовых ситуаций. Однако они менее склонны к стратегии избегания в конфликтах, к избеганию при выборе в неопределенных ситуациях. При этом они демонстрируют большую степень гибкости поведения в стрессовых, конфликтных ситуациях и при выборе в условиях неопределенности, а также большую осмысленность системы жизненных целей, чем 18-летние юноши-студенты.
The article aims to present the results of the study of the characteristics of the avoidance strategy as a coping behaviour, as a way of resolving conflicts, and as a model of decision making. The battery of tests includes the Amirkhan dominant Coping Strategies Identification test (CSI), the Thomas-Kilmann test of predisposition to conflict behaviour (TKI), the Melbourne Decision Making Questionnaire test (MDMQ), D.A. Leontiev Life-purpose orientations test (LPO). Sample size was n=70. Testing was conducted simultaneously among two groups of male students receiving a legal education. The first group consisted of 18-year-old students of 1-2 years of study (n=34). The second group consisted of 22-year-old students of 4-5 years of study (n=36). It was found that 22-year-old students are more prone to es-cape stressful situations. However, they are less inclined to an avoidance strategy in conflicts-to-avoiding when choosing in uncertain situations. At the same time, they demonstrate a greater degree of flexibility of behaviour in stressful, conflict situations and when choosing in conditions of uncertainty, as well as greater comprehension of the system of life goals than 18-year-old students. According to the authors of the article, this is due to the high level of development of the image of the professional world due to the higher level of mastering the chosen profession among 22-year-old students completing their studies, compared to their younger colleagues just starting vocational training.
Psychological transformation of the student’s personality in the conditions of digitalization of education
Authors: Корытова Галина Степановна 
Published: April 2024

В условиях цифровизации современной системы образования происходит психологическое развитие и трансформация личности обучающегося. Проблемные вопросы цифровизации российского образования относятся к числу наиболее активно обсуждаемых в современном психолого-педагогическом сообществе. Глобальная цифровизация привносит в образовательный процесс много новых возможностей, но ее последствия также представляют собой серьезные социальные и психологические проблемы. Цифровизация образования, применение новейших цифровых образовательных технологий, пребывание обучающегося в виртуальной среде оказывают существенное влияние на психологическое развитие ребенка, приводят к трансформациям его поведения, формированию специфической цифровой личности. В статье приведены результаты эмпирического исследования представлений педагогических работников о личностных и поведенческих особенностях современных обучающихся. Показано, что современные обучающиеся обладают психологическими свойствами и качествами, присущими представителям цифрового поколения.
In the conditions of digitalization of the modern education system, the psychological development and transformation of the student’s personality takes place. Problematic issues of digitalization of education are among the most actively discussed in the modern psychological and pedagogical community. The study of specific psychological characteristics of the personality of representatives of the digital generation (modern schoolchildren) is very relevant, since psychological scientists today are actively discussing how to build effective strategies for interpersonal communication and behavioral interaction with the digital generation. Global digital improvisation brings many new opportunities to the educational process, but its consequences also pose serious social and psychological problems. Digitalization of education, the use of the latest digital educational technologies, the student’s stay in a virtual environment have a significant impact on the psychological development of the child, lead to transformations of his behavior, the formation of a specific digital personality. The article presents the results of an empirical study of the ideas of teaching staff about the personal and behavioral characteristics of modern students. The results of the prototypical analysis of empirical data obtained during a remote survey of practicing teachers allow us to conclude that the modern student, as well as his personal properties and individual psychological characteristics, are statistically reliably associated with the attributes of digitalization and digital space. It is shown that modern students have the properties and qualities inherent in representatives of the digital generation.
Organization of phenological observations in geography at school
Authors: Ершова Татьяна Владимировна , Шмырова Дарья Евгеньевна , Петрова Елена Юрьевна 
Published: April 2024

Рассматривается проблема внедрения фенологических наблюдений в школе. Описана история фенологических наблюдений и России и Томске. Приведены примеры использования фенологических наблюдений в сельском хозяйстве. Проведен сравнительный анализ собственных фенологических наблюдений по 15 показателям за весенний период с 2021 по 2023 г. с результатами прошлых лет других авторов. Проанализировано содержание школьных учебников географии на наличие в них заданий по фенологии. Описывается участие одного из авторов в разработке заданий для Областного фенологического конкурса «Календарь природы» в Томской области. Методически разработаны и проведены четыре занятия в школе, которые направлены на формирование познавательных универсальных учебных действий и развитие мотивации к исследовательской деятельности. Показаны способы формирования у обучающихся навыков наблюдений за сезонными изменениями в природе в ходе урочных и внеурочных занятий по географии. Цель статьи состоит в популяризации фенологических наблюдений среди школьников Томской области.
The problem of the introduction of phenological observations in school is considered. The basic terms of phenology are given. A review of the literature on the use of phenological observations in agriculture is carried out. The history of phenological observations in Russia and Tomsk is described. The state of phenology in Russia and Tomsk at the beginning of the XXI century is described. The authors have developed 15 indicators of observations of phenological phenomena in Tomsk for the spring period. A comparative analysis of their own phenological observations for the period from 2021 to 2023 with the results of previous years by other authors is given. The importance of popularization of phenological observations among schoolchildren is actualized. The content of school geography textbooks is analyzed for the presence of phenology tasks in them. Methodically developed and conducted four classes at school in the section “Phenology”, which are aimed at the formation of cognitive universal learning activities and the development of motivation for research activities. The ways of forming students’ skills of observing seasonal changes in nature during scheduled and extracurricular geography classes are shown. It describes the participation of one of the authors of the article in the development of tasks for the Regional phenological competition “Nature Calendar” in the Tomsk region. 32 people from Tomsk, Pervomaisky, Molchanovsky, Chainsky, Kargasoksky, Verkhneketsky region, as well as from the city of Strezheva took part in the “Nature Calendar” competition. The purpose of the article is to popularize phenological observations among schoolchildren of the Tomsk region.
MATERI TARI GANDRUNG BANYUWANGI MENGGUNAKAN MULTIMEDIA BERBASIS WEB GOOGLE SITES
Authors: Anggraini Estu Candra , Sabri Indar , Suryandoko Welly 
Published: April 2024

Penelitian ini merupakan sebuah pengembangan dan penerapan berupa sebuah produk multimedia berbasis web google sites yang bertujuan memberi dan menyebarluaskan pengetahuan tentang Tari Gandrung Banyuwangi ditinjau dari berbagai elemen. Multimedia ini juga bertujuan sebagai upaya kecil pelestarian tari tradisional Banyuwangi yang bersifat pengenalan dan penyebarluasan informasi. Metode penelitian yang digunakan dalam pengumpulan dan analisis data yaitu kualitatif deskriptif dengan pengembangan produk menggunakan model ADDIE. Pengumpulan data dilakukan dengan observasi dan wawancara, sedangkan analisis data dilakukan dengan reduksi, penyajian data, dan penegasan simpulan. Model pengembangan produk yang digunakan yaitu analisis, desain, pengembangan, dan implementasi. Hasil penelitian menjelaskan bahwa produk ini dapat menambah pengetahuan pembelajar terkait berbagai elemen pendukung Tari Gandrung karena berisi materi secara kompleks, yaitu : sejarah perkembangan, jenis tari, ragam gerak, alat musik, iringan gendhing, busana dan beragam video jenis Tari Gandrung Banyuwangi. Selain digunakan pada pendidikan nonformal, multimedia ini juga dapat digunakan secara fleksibel pada pendidikan formal sebagai pelengkap pembelajaran.
BAHAN AJAR TARI OLANG BALEGO DALAM MEDIA DIGITAL CANVA UNTUK SEKOLAH MENENGAH ATAS
Authors: Rahmalia Siti , Heniwaty Yusnizar 
Published: April 2024

Aplikasi Canva adalah salah satu aplikasi yang banyak digunakan dalam pembelajaran, dikarenakan memberikan kemudahan bagi siswa untuk mempelajari materi yang diberikan oleh guru. Penelitan ini mendeskripsikan bagaimana materi tari dalam pembelajaran seni budaya dengan memanfaatkan aplicasi canva sebagai bahan ajar. Materi yang disusun merujuk pada KD 3.1 dan KD 4.1 berisi konsep teknik dan prosedur dalam ragam gerak tari tradisi yaitu tari Olang Balego. Metode penelitian menggunakan penelitian pengembangan oleh Borg & Gall dengan 10 tahapan yang dikelompokkan menjadi 5 tahapan yaitu: 1) Identifikasi Potensi Masalah, 2) Pengumpulan Data, 3) Desain Produk, 4) Validasi, dan 5) Revisi Desain. Sampel penelitian adalah Tari Olang Balego sbagai materi, dan 2 orang penari dari Prodi Pendidikan Tari, sebagai peraga. Hasil penelitian diketahui bahwa, avlikasi canva memiliki daya tarik berdasarkan kemasan yang dibuat dengan mendesain gambar, teks, warna, bentuk, dan audio, dari Tari Olang Balego sesuai KD. Sehingga hasil kemasan menjadi menarik untuk digunakan sebagai bahan ajar. Selain itu kelyakan dari hasil kemasan dibuktikan dari validasi oleh ahli media dengan kelayakan rata-rata 4,9 dan ahli materi dengan kelayakan rata-rata 4,7.
Převoditelnost práva stavby
Authors:   University of West Bohemia, Knaizl Zdeněk 
Published: April 2024

The contribution subject of the construction right was re-introduced into our legal system with effect of the Act No. 89/2012 Civil Code. The right of construction, as the only institute, allows the builder to implement a construction on someone else‘s land without this construction becoming part of it, thereby breaking the principle of superficio solo cedit. This post focuses on the transferability of building rights and the possibility of limiting the transferability. In particular, the issue of negotiating a ban on transferability is currently considered a controversial issue, and this contribution aims to map the current legal regulation and, based on the analysis, present arguments aimed at resolving this issue.
Ochrana proti bossingu ve světle aktuální judikatury
Authors:   University of West Bohemia, Kulawiak Petr 
Published: April 2024

The paper discusses a recently published decision in the Collection of Judicial Decisions and Opinions of the Supreme Court under No. 84, which dealt with the issue of unequal treatment of employees and the relevant circumstances in assessing the adequacy of monetary compensation for non-pecuniary damage. The value of the decision can be found not only in the fact that, in a legal sentence published in the Collection of Judicial Decisions and Opinions, it resolved the question of what legal regulation governs the legal means of protection against unequal treatment of employees, and at the same time contributed to further interpretative aspects in assessing the question of the adequacy of compensation for non-pecuniary damage, but also in the fact that it defined in fact the types of behaviour of an employer towards an employee which may have the characteristics of bossing.