bluuebunny/crossref_metadata_2025_split huggingface dataset:
RNA interaction and expression analysis of UHRF1 in breast cancer, gastric cancer, and colorectal cancer patients: systems biology investigation and experimental validation
Authors: Dayani Dorna , Sharifi Simin , Mohammadi Seyedeh Solmaz , Ghafourzadeh Masoumeh , Bahrami Sheida , Azaripour Melika , Karimi Nasim , Ghaneh Ali , Shirdeli Sayedeh Zahra , Rezaei Mohammad , Azadeh Mansoureh 
Published: April 2024

Abstract
Background
Breast cancer is the most commonly diagnosed cancer in women and ranks as the second most prevalent cancer globally. The prevalence of gastric cancer (GC) varies substantially between men and women, as well as in different countries. Male rates are two to three times higher than female rates. Colorectal cancer ranks as the third most common cancer globally and is the second leading cause of death related to cancer. In this study, our objective was to identify new non-coding biomarkers for breast cancer, gastric cancer, and colorectal cancer.
Method
Microarray analysis was performed to find the central protein-coding gene with the dysregulation in BC, GC, and CRC. Using ENCORI, validation of microarray analysis and survival analysis was utilized. RNA and protein interaction was performed by miRWalk, lncRRIsearch, and STRING. Signaling pathways were identified using Enrichr and Reactome databases. To validate the expression analysis and confirm the biomarker potential of RNAs, a qRT-PCR experiment was conducted.
Results
Based on microarray analysis, UHRF1 has a significant high expression in BC, CC, and GC. UHRF1 modulates DNA methylation and gene expression signaling pathways. lncRNAs EMX2OS and ZNF213-AS1 have interaction with UHRF1 mRNA. miR-4479 suppresses the expression of UHRF1 with interaction to 3’UTR region. qRT-PCR validates bioinformatics expression analysis. Furthermore, ROC analysis suggested that UHRF1, EMX2OS, and ZNF213-AS1 could potentially be used as diagnostic biomarkers for breast cancer, gastric cancer, and colorectal cancer.
Conclusion
miR-4479, lncRNAs EMX2OS, and ZNF213-AS1 regulate the DNA methylation signaling pathway via interaction with UHRF1. UHRF1, EMX2OS, and ZNF213-AS1 may be regarded as potential diagnostic biomarkers for breast cancer, gastric cancer, and colorectal cancer.
Rational development of FMN-based orthogonal riboswitch that functions in response to specific non-cognate ligand
Authors: Rode Ambadas , Ojha Divya 
Published: April 2024

Abstract
Re-engineering natural riboswitches into orthogonal RNA switches by making them functional in response to exogenous ligands but unresponsive to endogenous cognate ligands is a promising yet less explored strategy for developing gene regulatory tools. Herein, we have rationally engineered the aptamer domain of one of the largest and biotechnologically relevant flavin mononucleotide (FMN) riboswitch class, which specifically binds to synthetic ligands with high binding affinity (KD = ~54-75 nM) and regulates gene expression in vitro (EC50 = ~ 1.2 µM) and in E. Coli (EC50 = ~ 2.2 mM) while being unresponsive to FMN. To develop the orthogonal aptamers, we have rationally altered key tertiary interactions, such as A/G minor motifs and base triples located in the periphery of the FMN binding pocket. The biophysical and structural probing analysis of the orthogonal aptamer and synthetic ligand complex shows binding mediated by favorable enthalpic and unfavorable entropic contributions. Collectively, our rational approach can be extended to engineer other riboswitch classes for developing synthetic RNA devices in prokaryotes and eukaryotes for biomedical applications.
Antifungal Activity of Chitosan Nanocomposites against Candida albicans: A Systematic Review
Authors: Shakib Pegah , Fallahi Shirzad , Goudarzi Gholamreza , Ahmadi Somaghian Shahram , Amiri Sana , Nemati Delfan Sirus , Cheraghipour Kourosh 
Published: April 2024

Background:
This investigation aims to explore the potential anti-Candida albicans
effects of Chitosan nanocomposites.

Methods:
Researchers searched several databases, including Scopus, PubMed, Science Direct,
Cochrane, and Ovid, for articles published between 2000 and 2023 using specific keywords.

Results:
Of the 5,600 studies that were first searched in the databases, after removing duplicates
(700 cases) and applying inclusion and exclusion criteria, 43 studies were selected for evaluation
after duplicate removal.

Conclusions::
According to studies, the anti-Candida albicans properties of chitosan nanocomposites
are more than routine antifungals such as nystatin; therefore, it can be concluded that Chitosan
nanocomposites can be used to deal with Candida albicans.
Eukaryotic Initiation Factor 3C Can Affect the Proliferation and Invasion of Ovarian Cancer by Regulating the p53 Signalling Pathway
Authors: Zhang Jingkaiwen , Yang Hanlin , Wen Fang , Li Qing , Luo Hao , Zi Dan 
Published: April 2024

Background:
Eukaryotic Initiation Factor 3C (EIF3C) represents a pivotal translational
initiation factor in eukaryotes and has been shown to facilitate the progression of various neoplasms.
However, its mechanistic role in ovarian cancer remains elusive.

Methods:
In this research, the expression of EIF3C in ovarian cancer tissues was investigated using
immunohistochemistry. In addition, the assessments were made on changes in cellular proliferation,
invasion, and apoptotic abilities by reducing the expression of EIF3C in ovarian cancer
cells. By utilizing microarray analysis, a comparison was performed between the downregulated
EIF3C group and the control group of ovarian cancer cells, revealing the genes that were expressed
differently. Furthermore, the signalling pathways associated with cellular proliferation
were validated. The functional role of EIF3C in vivo was investigated using a xenograft tumour
model.

Results:
The immunohistochemical analysis showed that elevated levels of EIF3C are linked to a
negative prognosis in patients with ovarian cancer. Suppression of EIF3C greatly hindered the
growth and spread of SK-OV-3 and HO-8910 cells while enhancing cellular programmed cell
death. Following KEGG and GSEA enrichment analyses of differentially expressed genes, the
p53 signalling pathway was found to be associated with EIF3C. Suppression of EIF3C resulted in
the upregulation of the p53 signalling pathway, leading to the inhibition of cell proliferation and
invasion and the promotion of apoptosis. In vivo experiments demonstrated that EIF3C knockdown
suppressed the growth of subcutaneous tumours in nude mice.

Conclusion:
There is a correlation between overexpression of EIF3C in tumour tissues of ovarian
cancer patients and this is associated with a poorer prognosis. By influencing the p53 signaling
pathway, EIF3C facilitates the growth and infiltration of cells in ovarian cancer.
Pharmacogenomics: Importance in Exploration of Target Molecule,
Drug Resistance and Mechanism in Cancer Chemotherapy
Authors: Kumari Pooja , Tengli Anandkumar 
Published: April 2024

Background:
The field of pharmacogenomics investigates the ways in which
genes impact the body's reaction to drugs. Through the integration of genetics and medical
knowledge, it is possible to develop individualised and efficient therapies that are
based on genetic profiles. Specifically, this evaluation focuses on three aspects: Finding
molecular targets and gaining a grasp of their structures is the first step. 2. Using pharmacogenomics
to lessen the harmful effects of drugs 1. 3. Predicting pharmacological
mechanisms based on genetic variances.

Methods:
A systematic review examining pharmacogenomics' role in cancer chemotherapy,
focusing on target molecules, drug resistance, and mechanism, was conducted using
PRISMA-compliant databases. The review included English-published journals from
2000-2023, aiming to reduce bias and ensure all relevant research is found, chosen, and
critically assessed.

Results:
The results show that over the past 20 years, cytotoxic medications and personalized
treatments have significantly improved cancer treatment strategies. Targeted drugs,
small molecule drugs, and pharmacogenomic biomarkers offer targeted treatment for carcinoma
tissues.

Conclusion:
Understanding genetic profiles and drug resistance is crucial for effective
cancer treatment. Combination therapies have advanced treatment for advanced or metastatic
cancers.
ASGE Predictors for the Diagnosis of Choledocholithiasis: Validation in a
Public Hospital of Merida, Yucatan, México
Authors: Aguirre-Sanchez Richard Camilo , Hernan-Herrera-Sanchez Abraham , Perez-Osorio Carlos Enrique , Cardenas-Marrufo Maria Fidelia 
Published: April 2024

Background::
Choledocholithiasis is defined as the presence of calculus in the biliary tract, and is one of the main complications of cholelithiasis. Its prevalence among the Mexican pop-ulation is 14%.

Objective::
To determine the validity of predictors of choledocholithiasis in patients attending the Hospital Agustin O’Horan from January 2019 to December 2020.

Methods::
This was an observational, analytical, and retrospective study. It included patients with a diagnosis of choledocholithiasis, and it evaluated the sensitivity, specificity, as well as positive and negative predictive values for risk criteria of the American Society for Gastrointestinal Endoscopy (ASGE)

Results::
Ninety-six medical histories were analyzed. Ninety were from women and six from males (94% and 6% respectively), and the average age was 40 years. The registry shows an increase of serum ALP, AST, and ALT in 98% of the reports, and elevated levels of bilirubin in 19% by 1.3-4 mg/dl, and 76% by >4mg/dl of them. Moreover, the records showed pancreatitis and cholangitis (8% each one). The ultrasound reports indicates that 96% of the patients had a choledochal cyst higher than 5 mm, while 54% had a choledochal litho. Sensitivity and specificity of ASGE criteria for the diagnosis of choledocholithiasis was 96.6% and 45.5% respectively, and a Positive Predictive Value of 16% and a Negative Predictive Value of 99%.

Conclusion::
It is considered that the diagnostic accuracy test of the ASGE criteria for the diagnosis of choledocholithiasis is high.
The Therapeutic Potency of Silver/Chitosan, Silver/Saponin and Chitosan/ Saponin Nanocomposites on Ethanol-induced Gastric Ulcers in Wistar Rats
Authors: Hassan Maha Ahmed Taha , Soliman Amel M. , Mohamed Ayman Saber 
Published: April 2024

Background:
The annual incidence of peptic ulcer disease is estimated to be four
million cases worldwide, with an average lifetime risk of 7.5% in individuals of all ages. Polymer
nanocomposites have novel prospects in the field of modern medicine.

Objective:
The present research endeavors to assess the therapeutic efficacy of nanoparticles
composed of silver/chitosan, silver/saponin, and chitosan/saponin against gastric ulcers induced
by ethanol in Wistar rats.

Methods:
Forty-eight rats were randomly split into eight groups of the same size. Oral ethanol
(5 ml/kg of body weight) was given to all rat groups except the control one for 1 hour before
treatment. Control and ulcer groups of rats were given distilled water orally. The rats in the other
groups were given orally 1/10 LD50 of each treatment as follows: AgNPs, chitosan NPs, Saponin,
AgNPs-Chitosan NPs, AgNP-Saponin, and chitosan-Saponin NPs.

Results:
NP-treated groups showed a significant increase in the gastric juice pH, glutathione
reduced, catalase, and nitric oxide while gastric juice volume, ulcer index, and malondialdehyde
levels decreased compared with the ulcer group. Histopathological investigation of stomach
showed improvement in NPs groups specially in the chitosan-Saponin NPs group.

Conclusion:
The current study revealed that silver-chitosan, silver-saponin and chitosansaponin
nanocomposites effectively treat gastric ulcers. Chitosan-Saponin nanoparticles showed
high therapeutic effectiveness against gastric ulcer in rats.
The Association between use of Renin-Angiotensin-Aldosterone System Inhibitors and the Risk and Mortality of Pancreatic Cancer: A Systematic Review and Meta-Analysis
Authors: Rahimi Rasoul , Hashemi Rafsanjani Seyed Mahmood Reza , Heidari-Soureshjani Saeid , Sherwin Catherine Mary Turner , Kasiri Karamali 
Published: April 2024

Background:
Pancreatic Cancer (PC) is one of the most malignant tumors and highly invasive
neoplasms around the world.

Objective:
This systematic review and meta-analysis aims to study the relationship between the use
of renin-angiotensin-aldosterone system inhibitors and the incidence and mortality of PC.

Methods:
The electronic search was conducted systematically until October 10, 2023. in databases,
including Scopus, Web of Science (WOS), PubMed/MEDLINE, Cochrane Library, and Embase.
The required data were extracted from the articles and were analyzed by Stata 15 using statistical
tests (Chi-square and I2), Forest plots, and publication bias tests (Begg's and Egger's tests).

Results:
A total of four studies (2011-2019; n=314,856) investigated the relationship between RAS
antagonists and PC risk. No significant associations were found between angiotensin receptor
blockers (ARBs) (OR=0.94, 95% CI: 0.77-1.14, p=0.513), angiotensin-converting enzyme inhibitors
(ACEIs) (OR=0.96, 95% CI: 0.84-1.09, p=0.505), or combination therapy (ARBs + ACEIs)
(OR=0.97, 95% CI: 0.87-1.09, p=0.627) and PC risk. Also, nine studies (2010-2023; n=20,483) examined
the association between renin-angiotensin-aldosterone system inhibitors and PC mortality.
Significant reductions in PC mortality were found for ARBs (OR=0.81, 95% CI: 0.66-0.98,
p=0.032), ACEIs (OR=0.89, 95% CI: 0.80-0.99, p=0.038), and combination therapy (OR=0.83,
95% CI: 0.70-0.97, p=0.022). No evidence of publication bias was found in the study results.

Conclusion:
In summary, while renin-angiotensin-aldosterone system inhibitors did not appear to
impact PC risk, their use was associated with lower PC mortality based on this meta-analysis of the
current evidence. More rigorous and well-designed studies are required to validate and support these
findings.
Challenges of E-waste Management in Sabah: A systematic review
Authors: Mohd Rahman Dayang Masleha , Dusim Haidy Henry , Kassim Asiyah 
Published: April 2024

E-waste management is becoming more complex as society's reliance on technology grows. Due to the effects on the environment and human health, proper disposal is essential. Through systematic review of 25 articles using PRISMA methodology, this paper explores the e-waste challenges in Sabah, Malaysia. The study discovered that among the challenges are things like poor infrastructure, informal recycling, and little knowledge and awareness. This discovery offers insightful information that will help stakeholders, including policymakers, researchers, and researchers, develop sustainable solutions to the e-waste problems in Sabah in particular.
Pengaruh Capital Intensity, Investment Opportunity Set dan Corporate Social Responsibility terhadap Konservatisme Akuntansi: Studi Empiris pada Perusahaan Food and Beverage yang Terdaftar di Bursa Efek Indonesia tahun 2018-2022
Authors: Zelvira Rahma , Honesty Fiola Finomia , Honesty Helga Nuri , Pebriyani Dewi 
Published: April 2024

This study will examine the relationship between capital intensity, investment opportunities and corporate social responsibility on accounting conservatism. The scope of this research includes food and beverage companies with a total sample of 24 companies spanning a period of 5 years, namely from 2018-2022, so the total research sample is 120 food & beverage companies using a purposive sampling method based on certain criteria. The data in this research uses secondary data using the eviews analysis method. The research results show that capital intensity, investment opportunities and corporate social responsibility have no effect on accounting conservatism.
Examining the Synthesis of Islamic Commercial Principles and Local Customary Practices: A Case Study of Nyambut Sawah Traditions in Tejamari, Banten
Authors: Jamaluddin Jamaluddin , Hayat Milatul , Masduki Masduki , Mukarromah Oom , Jamaludin Jamaludin 
Published: April 2024

The influence stemming from the intersection of local traditions and religious percept manifests itself in the practice of nyambut sawah (paddy cultivation) among the Tejamari community. This practise resembles the utilisation of agricultural land (muzāra’ah) in Islamic commercial law (fiqh mu’āmalah), wherein landowners provide agricultural land to cultivators for cultivation with a profit-sharing system. This article aims to analyse the extent to which the practice of nyambut sawah adopts the principles of Islamic commercial law. This study employs a normative-empirical approach, conducting observations and interviews with eighteen informants. The research finds that the nyambut sawah tradition practiced by the Tejamari community reflects the muzāra’ah contract in fiqh mu’āmalah. The muzāra’ah contract is reflected in five models of profit-sharing systems, wherein the division of tasks, responsibilities, profits, and risks has been mutually agreed upon. Despite differences in opinion regarding the responsibility for the cost of rice milling (ngeprik padi), this practice still maintains values of mutual assistance between landowners and cultivators in overcoming economic difficulties. This article argues that local traditions and religious values can together provide solutions for the sustainability of agricultural activities.
[Pengaruh interaksi tradisi lokal dengan agama tampak dalam praktik nyambut sawah di kalangan masyarakat Tejamari. Praktik ini menyerupai pemanfaatan lahan pertanian (muzāra’ah) dalam fikih muamalah, di mana pemilik tanah menyediakan lahan pertanian kepada penggarap untuk ditanami dengan sistem bagi hasil. Artikel ini bertujuan untuk menganalisis sejauh mana praktik nyambut sawah mengadopsi prinsip-prinsip hukum bisnis Islam. Studi ini menggunakan pendekatan normatif-empiris, melakukan observasi dan wawancara dengan delapan belas informan. Penelitian menunjukkan bahwa tradisi nyambut sawah yang dipraktikkan oleh masyarakat Tejamari mencerminkan kontrak muzāra’ah dalam fikih muamalah. Kontrak muzāra’ah tercermin dalam lima model sistem bagi hasil, di mana pembagian tugas, tanggung jawab, keuntungan, dan risiko telah disepakati secara bersama. Meskipun terdapat perbedaan pendapat mengenai tanggung jawab atas biaya ngeprik padi (penggilingan padi), praktik ini tetap mempertahankan nilai-nilai saling tolong-menolong antara pemilik lahan dan penggarap dalam mengatasi kesulitan ekonomi. Artikel ini berargumen bahwa tradisi lokal dan nilai-nilai agama dapat bersama-sama memberikan solusi untuk keberlanjutan kegiatan pertanian.]
Sociology of power P.E. Kazansky: unlimited and self-limited autocracy
Authors: Smolin M. B. 
Published: April 2024

The article is devoted to the concept of power of the professor of the Imperial Novorossiysk University Pyotr Evgenievich Kazansky (1866–1947), described in the capital study “The Power of the All-Russian Emperor. Essays on the Current Russian Law” (Odessa, 1913).This study was devoted to the supreme power, which, under any political principle, always exists alone in the state. The study deals with the supreme state power, its manifestations in various areas of public administration during the Duma monarchy. The book is devoted to the tradition of Russian state power, the clarification of its historical place in society and the state and its power activities. Professor P.E. Kazansky claims that the emperor possessed not only executive, legislative or judicial power, but also the Supreme Power of the Empire, which directed the activities of all subordinate departments.
University Didactic 4.0 for Professionals of the 21st Century
Authors: Acuñar Edwin Gerardo Acuña 
Published: April 2024

Objective: This study investigates the impact of transitioning towards "University 4.0" on shaping professionals capable of addressing the 21st-century challenges. It highlights the integration of advanced technologies and innovative pedagogical approaches in higher education.

Theoretical Framework: The study focuses on the necessity for higher education to adapt to advanced methodologies and technologies to meet the demands of the knowledge society and the digital economy. It emphasizes the importance of ICT in educational transformation and the evolution of the teacher's role towards a learning facilitator.

Method: Descriptive analysis based on bibliographic review and surveys conducted with students and teachers, exploring emerging pedagogical practices and the integration of telelearning resources and ICT in educational environments.

Results and Discussion: A significant transformation towards more interactive and student-centered learning is revealed. The advantages of digital technologies in teaching and the challenges related to accessibility and equity are discussed.
Research Implications: Suggests the need for a holistic approach that integrates technical, cognitive, and social competencies to properly prepare future professionals. It underlines the importance of overcoming technological and pedagogical barriers for a more inclusive and effective education.

Originality/Value: Provides a comprehensive perspective on the evolution of university didactics towards education 4.0, emphasizing the need to adapt to technological and sociocultural changes to form competent and versatile professionals in the global and technologically advanced context of the 21st century.
The Effects of Work-Family Conflict and Work-Family Support on Job Performance of Chinese Grassroots Civil Servants
Authors: Jia Li , Phawitpiriyakliti Chaithanaskorn , Terason Sid 
Published: April 2024

Objective: As an important and special professional group in Chinese society, the career development of grassroots civil servants has received much attention. With the development of information technology and the strengthening of workplace competition, new conflicts between work and family continue to intensify, and their conflict issues have received widespread attention.

Theoretical framework: This study focuses on grassroots civil servants and explores the impact of work family relationships on job performance. Theoretical assumptions are proposed based on management science theory and previous research on the relationship between variables.

Method: Obtain survey data and interview response texts through questionnaire surveys and semi-structured interviews. The proposed hypothesis was validated based on quantitative and qualitative analysis methods.

Results and Conclusion: The empirical results indicate that the quality and balance of work family relationships have a significant impact on job performance, and work engagement and job burnout play a mediating role in the influencing process.

Implication of the Study: The research results enrich the systematic exploration of the specific context of work family relationships and the impact of groups on work behavior, which is conducive to improving humanized and organized management mechanisms, providing guidance for the practice of work family coordination and division of labor within the grassroots civil servant team.

Originality/Value: The study aims to improve the living and development environment of grassroots civil servants, and stimulating deep work motivation.
A Model for Determining CO2 Emission Reduction Targets in China's Oil and Gas Industry
Authors: Lyu C. , Lv Y. , Zhang J. 
Published: April 2024

Abstract
The climate disasters caused by extreme climate change have brought great harm to humanity. This article attempts to propose a balanced CO2 emission perspective by constructing a CO2 emission reduction tolerance function and cost function. Using China's CO2 emission data of China's Oil and Gas Industry over the past 20 years, data on the losses caused by CO2 emission accumulation to the environment and society, and national income data, empirical analysis is conducted on the constructed function to determine a reasonable CO2 emission amount and provide a scientific basis for the country to formulate a scientific and reasonable CO2 emission reduction ratio.