bluuebunny/crossref_metadata_2025_split huggingface dataset:
[123I]iodomethane, a main product in the synthesis of 5‐[123I]iodo‐6‐nitroquipazine by iododestannylation
Authors: Zea‐Ponce Yolanda , Baldwin Ronald M. , Miliust Richard A. , Bakthavachalam Venkatesalu , Innis Robert B. 
Published: October 2006

AbstractRadioiodinated 5‐iodo‐6‐nitroquipazine (2‐piperazinyl‐5‐iodo‐6‐nitroquinoline), a selective serotonin transporter radiotracer, can be prepared by the reaction of its N‐t‐BOC‐5‐trimethylstannyl precursor with [125I] or [123I]NaI in the presence of chloramine‐T, followed by amine deprotection by heating under acidic conditions. However, the labeling reaction is associated with a large and consistent formation of a volatile radioactive reaction product [37 ± 4% (n = 11] for 123I and 40 ± 4% (n = 3) for 125I).The purpose of these experiments was to characterize the volatile radioactive product and to examine the effect of reaction temperature on its formation. The volatile radioactive product was identified as [125I] or [123I]iodomethane by its trapping characteristics and by its retention time in two different HPLC systems. Changing the reaction temperature (22–124°C) did not have a significant effect in the amount of labeled iodomethane produced (n = 13).The conditions chosen for the radioiodination and deprotection were: 50 μg precursor in MeOH, dry Na123I, 50 μl 0.02 M chloramine‐T in glacial HOAc/MeOH, heating at 90°C for 15 min, followed by deprotection with CF3CO2H for 5‐10 min at the same temperature. Purification was achieved by solvent extraction and HPLC.Radiochemical yields for preparations carried out at temperatures between 86°C and 124°C were 24 ± 5% (n = 11) for [123I]‐ and 45 ± 13% (n = 3) for 5‐[125I]iodo‐6‐nitroquipazine; radiochemical purity averaged 95 ± 4% and 99 ± 0% respectively.
Synthesis of carbon‐11 labeled methylcarbamates from [11C]‐methylchloroformate
Authors: Ravert Hayden T. , Mathews William B. , Musachio John L. , Dannals Robert F. 
Published: October 2006

Abstract[11C]‐Methylchloroformate, a novel [11C]‐acylating agent, was generated in situ from [11C]‐methanol and phosgene. To explore the utility of [11C]‐methylchloroformate, this agent was reacted with several amines to yield their corresponding [11C]‐labeled methylcarbamates. The average synthesis (including purification and formulation) required approximately 23 minutes from end of bombardment. The average specific activity was calculated to be approx. 607 mCi/μmole at end of synthesis with an average radiochemical yield of 6%, decay corrected to starting [11C]‐methanol. Preliminary results reveal that [11C]‐methylchloroformate is a useful general reagent for the preparation of [11C]‐methyl carbamates of both primary and secondary amines.
An efficient synthesis of carbon‐14 labelled vigabatrin
Authors: Gill Harpal S. 
Published: October 2006

AbstractVigabatrin‐[6‐14C] ((R, S)‐4‐amino‐5‐hexenoic‐[6‐14C] acid) was synthesized by employing Wittig condensation of 1‐(1‐butenyl)‐2‐oxo‐5‐pyrrolidinecarboxaldehyde with methyl‐[14C]‐triphenylphosphonium iodide as the key step. The synthetic sequence involved 3 steps and produced the title compound in 70% overall yield with a radiochemical purity of 100%.
Synthesis of deterium labeled plant ethylene precursor
Authors: Nam Kye Chun , Rapoport Henry 
Published: October 2006

AbstractSynthetic methods for the preparation of β‐deuterium labeled 2‐keto‐4‐methylbutyric acid were investigated. Vinyl chloride was first reacted with the ethyl oxalyl chloride moiety using aluminum chloride as condensing agent and the addition of methyl mercaptan followed. Deuterium labeling was achieved by using NaBD4 reduction in pyridine.
Preparation and biological evaluation of technetium‐99m‐phenylethylamine complexes
Authors: Vitale Arturo A. , Calviño María Ana , Ferrari Carina C. , Stahl Adriana E. , Pomilio Alicia B. 
Published: October 2006

AbstractBiological and chemical characteristics of 99mTc‐phenethylamines complexes are presented. 2‐(4,5‐Dimethoxy‐2‐nitrophenyl)ethylamine, 2‐(3,4‐dimethoxyphenyl)ethylamine and 2‐(2‐amino‐4,5‐dimethoxyphenyl)‐ethylamine were used as ligands. A preliminary evaluation of these 99mTc‐complexes as dopamine receptor radioligands was also performed. Net charges at each atom were also calculated by a semiempirical ZINDO/1 method for comparison of free ligands' parameters with those of the respective technetium‐complexes.
Preparation of [14C]Musk Xylol
Authors: Lewin Anita H. , Ramesh Usha 
Published: October 2006

AbstractCarbonation of the aryl lithium obtained from 5‐t‐butyl‐3‐iodotoluene with carbon‐14 labeled carbon dioxide, followed by reduction gave [ArCH3‐14C]‐5‐t‐butyl‐m‐xylene. Nitration of this material gave [ArCH3‐14C]‐5‐t‐butyl‐2,4,6‐ trinitro‐m‐xylene, known as Musk Xylol. The overall yield was 32% and the product had specific activity 19.8 mCi/mmol (66 mCi/mg) and was > 99% pure.
Carbon‐11 labelled analogs of alanine by the strecker synthesis
Authors: Prenant Christian , Theobald Annemarie , Siegel Thilo , Joachim Jürgen , Weber Klaus , Haberkorn Uwe , Oberdorfer Franz 
Published: October 2006

AbstractDerivatives of alanine, α‐[2‐11C]aminoisobutyric acid 1a and α‐(N‐methyl)‐[2‐11C]aminoisobutyric acid 1b were prepared for the in‐vivo study of amino acid transport phenomena by positron‐emission‐tomography (PET). Compounds 1a and 1b were obtained by a Zelinski‐Stadnikoff variant of the Strecker α‐amino acid synthesis from in‐situ formed [11C]acetone in presence of sodium cyanide and either ammonium sulfate (for 1a) or methylamine hydrochloride (for 1b). The complete preparation required 50 min from the end of [11C]CO2 production, and delivered 1.2 ‐ 2 GBq of labelled product for application (2.4 ‐ 4%; not corrected for decay; related to trapped [11C]CO2). The specific activity of the labelled products was 16 to 20 GBq·μmol−1. The radiochemical and chemical purity of the preparations was greater than 98%.
Synthesis of 1‐[13CD3]‐9‐cis‐retinoic acid
Authors: Bennani Youssef L. 
Published: October 2006

Abstract1‐[13CD3]‐9‐cis‐Retinoic acid was prepared in 8 steps from 2,6‐dimethylcyclohexanone. Alkylation of 2,6‐dimethylcyclohexanone under LiHMDS/MnBr2/13CD3I gave the corresponding labeled 2‐[13CD3]‐2,2,6‐trimethylcyclohexanone 4 in good yield. Further functionalization of 4 to 6‐[13CD3]‐β‐cyclocitral 6 proceeded through a Shapiro reaction. Aldehyde 6 was condensed with ethyl 3,3‐dimethylacrylate to afford the corresponding bicyclic pyranone 7. Reduction of 7 to lactol 8, followed by acid‐catalyzed ring opening gave the 9‐cis‐aldehyde 9. Wittig‐Horner olefination and saponification afforded the title compound in good overall yield and in excellent isotopic purity.
Synthesis of H‐3 labeled 5‐fluoro‐3‐[3‐[4‐(5‐methoxy‐4‐pyrimidinyl)‐1‐piperazinyl]propyl]‐1H‐indole, a serotonergic agent with potential antidepressant activity
Authors: Dischino Douglas D. , Combrink Keith D. , Doweykos Lidia , Morimoto Hiromi , Pearce Bradley C. , Williams Philip G. , Yevich Joseph P. 
Published: October 2006

AbstractThe title compound was prepared by the LiAlT4 reduction of 5‐fluoro‐3‐[3‐[4‐(5‐methoxy‐4‐pyrimidinyl)‐1‐piperazinyl]‐3‐oxopropyl]‐1H‐indole. The radiochemical purity of the product was 98.9% and the specific activity was calculated as 53.0 Ci/mmol from HPLC analyses and 55.6 Ci/mmol from 3H NMR measurements.
Synthesis of 6‐[18F]fluorodopamine, 6‐[18F]fluoro‐m‐tyramine and 4‐[18F]fluoro‐m‐tyramine+
Authors: Namavari Mohammad , Satyamurthy N. , Barrio Jorge R. 
Published: October 2006

AbstractA new method for the preparation of 6‐[18F]fluorodopamine (3) and [18F]fluorinated analogs of m‐tyramine based on a regioselective radiofluorodestannylation reaction has been developed. The radiofluorodestannylation of 6‐trimethylstannyldopamine derivative 1 was carried out with [18F]F2 to give the corresponding [18F]fluoro intermediate 2. Acid deprotection of 2 with 48% HBr followed by HPLC purification afforded 6‐[18F]fluorodopamine (3) in 18% radiochemical yield. Similarly, 6‐ and 4‐[18F]fluoro‐m‐tyramines (6a and 6b) were prepared from their corresponding trimethylstannyl‐m‐tyramine derivatives in 25 and 8% radiochemical yields, respectively. In all cases, after HPLC purification of the final products, tin concentrations were found to be <15 ppb.
Carbon‐14 labelled nitrogen heterocycles; the syntheses of three phosphodiesterase inhibitors
Authors: Lawrie Kenneth W M , Novelli Christine E A , Saunders David , Coates William J 
Published: October 2006

AbstractThe syntheses of three heterocyclic phosphodiesterase inhibitors are described from a common radiolabelled precursor, namely 2‐propoxybenzo[cyano‐14C]nitrile. Conversion of the nitrile to the corresponding methyl ketone or amidine allows elaboration of the heterocycles radiolabelled within the ring systems.
Synthesis of [14C]KT3‐671, 2‐Propyl‐8‐oxo‐1‐[ (2′‐(1H‐[14C] tetrazole‐5‐yl) biphenyl‐4‐yl) methyl]‐4,5,6, 7‐tetrahydro‐cycloheptimidazole, a novel potent nonpeptide angiotensin II receptor antagonist
Authors: Ueyama Naoto , Yanagisawa Takashi , Tomiyama Tsuyoshi 
Published: October 2006

Abstract2‐Propyl‐8‐oxo‐1‐[(2′‐(1H‐tetrazole‐5‐yl) biphenyl‐4‐yl)methyl]‐4, 5, 6, 7‐tetrahydrocyclohept imidazole (KT3‐671), which has been found to be a potent and selective angiotesin II receptor antagonist, was synthesized in 14C‐labelled form by using potassium[14C]‐cyanide. [14C](KT3‐671) 9 with a specific activity of 1.74GBq/mmol was prepared in four steps in 29.8% overall radio‐chemical yield from potassium[14C]‐cyanide.
Synthesis, resolution and radioiodination of S(−)trans‐5‐hydroxy‐2‐[N‐n‐propyl‐N‐(3′‐iodo‐2′‐propenyl)amino]tetralin‐S(−)trans‐5‐OH‐PIPAT: A new dopamine D2‐like receptor ligand
Authors: Chumpradit Sumalee , Kung Mei‐Ping , Vessotskie Janet , Kung Hank F. 
Published: October 2006

AbstractA new dopamine D2‐like receptor ligand, (R,S)trans‐5‐hydroxy‐2‐[N‐n‐propyl‐N‐(3′‐iodo‐2′‐propenyl)amino]tetralin ((R,S)trans‐5‐OH‐PIPAT, 3), based on high affinity dopamine receptor agonist 5‐hydroxy‐2‐[N,N‐(di‐n‐propyl)‐2‐amino]tetralin (5‐OH‐DPAT, 1). was prepared. The synthesis was achieved by a reductive amination of 5‐methoxy‐2‐tetralone with n‐propylamine, followed by N‐alkylation, to afford 5‐methoxy‐N‐propyl‐N‐2′‐propynyl‐2‐aminotetralin, 7. Reduction of 7 with tributyltin hydride gave the tri‐n‐butyl tin derivative, 8, which was converted to 9 by an iododemetalation reaction. Demethylation of 9 gave the desired compound, (R,S)trans‐5‐OH‐PIPAT, 3. The resolved (R) and (S)trans‐5‐OH‐PIPAT, 3 were also quantitatively prepared. In vitro binding studies showed the stereoselectivity of this new compound for binding to dopamine D2‐like receptors. S(‐)‐3 displayed high binding affinity, with inhibition constants (Ki) of 0.38, 0.09 and 0.67 nM for dopamine D2H (expressed in HEK293 cells), D3 (expressed in Sf9 cells) and D4H receptors (expressed in CHO cells), respectively. Using the same binding assays, the less active R(+) isomer displayed Ki values of 7.29, 4.87 and 16.44 nM for D2H, D3 and D4H receptors, respectively. In addition, radiolabeling was successfully performed, either with the racemic tin derivative, (R,S)‐11, or using the optically resolved tin derivatives R(+)‐or S(‐)‐111, to give the final radiolabeled product, [125I]R(+) or S(‐)‐3.
Synthesis of two series of cysteine‐specific spin labels containing a 15N substituted nitroxide
Authors: Wu Ge 
Published: October 2006

AbstractSynthesis of two series of spin labels with a cysteine‐reactive group, either maleimide or methanethiosulfonate, and a 15N substituted nitroxide separated at variable distance is reported. In the synthesis, the cysteine‐reactive groups were first incorporated into the target molecule and the 15N substituted nitroxide was introduced in the last step via a mild reaction without destroying the cysteine‐reactive groups. The synthetic routes described here are applicable to the synthesis of spin labels with either 15N substituted or “normal” 14N nitroxide. Spin labeling of cysteine residues in rhodopsin by the newly synthesized spin labels was also demonstrated.
Mechanism of steroidal enol ether formation. Configuration of tritium at C‐6 of estra‐1, 3, 5(6)‐trien‐3‐OL‐17‐one‐6,7‐3H as established during the synthesis of 19‐nor‐17α‐pregna‐3, 5‐dien‐20‐yn‐17‐OL‐7‐3H 17‐acetate
Authors: Merrill Edward J. , Vernice Gerald G. 
Published: October 2006

AbstractThe nature of the reactions involved in the synthesis of 3‐cyclopentyloxy‐19‐nor‐17α‐pregna‐3, 5‐dien‐20‐yn‐17‐ol‐7‐3H 17‐acetate, allowed the determination of the stereochemistry of the tritium atoms at C‐6 in some of the precursors. One of these precursors was estra‐1, 3, 5 (6)‐trien‐3‐ol‐17‐one‐6, 7‐3H in which 82% of the tritium was in the 6α position and 18% in the 68 position.Supportive evidence for the mechaniam of enol ether formation was obtained, also. Acid catalysed enol ether formation, stereospecifically removed the triton form the 68 position. On hydrolysis of the enol ether, the proton stereospecifically entered the 68 position. Equilibration with base completed the removal of the tritium from the C‐6 position.
The synthesis of 14C‐labelled 1‐(4‐chlorophenyl) ‐2‐methyl‐2‐amino‐propane hydrochloride (chlorphentermine, Desopimon®)
Authors: Engler J. , Pallos L. 
Published: October 2006

AbstractThe preparation of 14C labelled 1‐(4‐chlorophenyl)‐2‐methy 1‐2‐aminopropane hydrochloride is described. The radioactive carbon was introduced into the central position of the aminopropyl group in order to study the pharmacological properties and mode of action of the anorexigenic drug. The synthesis started from Ba14CO3, involved 3 steps, and a radiochemical yield of 23% was obtained. The chemical and radiochemical purity of the end‐product was proved by thin layer chromatography and autoradiography.
Synthesis of carbon‐14 and tritium labeled glyburide
Authors: Hsi R. S. P. 
Published: October 2006

AbstractN‐[4‐]2‐(5‐Chloro ‐2‐methoxybenzamido) ethyl phenylsulfonyl N′ ‐cyclohexylurea, IXc, or glyburide, has been labeled with tritium and carbon‐ 14. The tritium label is located in the C‐3 position of the 5‐chloro ‐2‐methoxybenzoyl portion of the molecule, while the carbon‐14 label is incorporated into the C‐2 position of the 2‐phenlethylamine moiety in the compound.The specific activities of the tritium and carbon‐14 labeled products are 8.50 mCi/mM and 3.66 mCi/mM, respectively.
Synthesis of 2, 7‐bis [2‐(diethylamino) ethoxy] fluoren‐9 14C‐one. 2HCL; (tilorone‐914C hydrochloride
Authors: Gaur V. P. , Wacker A. 
Published: October 2006

AbstractTilorone hydrochloride bis‐deae‐fluorenone‐914C) labelled with carbon‐14 in position 9 was synthesized in 8 steps on 0.5 millimolar scale. Starting from biphenyl‐2‐carboxylic‐14C‐acid (I), fluorenone‐914C (II) and fluoren‐914C (III) were prepared by established radiochemical procedures [1, 2, 3]. Sulfonation of III gave fluoren‐914C‐2, 7‐disulfonic acid (IV), which was converted to its potassium salt and oxidized with KMnO4 to obtain 9‐oxo‐914C‐disulfonic acid dipotassium salt (V) in yields of 60% and 80% respectively. This was fused with NaOH at 325°C to get 4,4′‐dihydroxybiphenyl‐2‐carboxylic‐14C‐acid (IV) in 67% yield. VI on dehydration with ZnCl2 gave 2, 7‐dihydroxy‐9‐oxo‐fluoren‐914C (VII) with 82% yield.Condensation of VII with 2‐diethylaminoethyl chloride in presence of KOH resulted in the synthesis of the title compound in overall yield of 15% based on the amount of I used.Characterisation data to establish the chemical and radiochemical purity are included. The labelled preparation showed the same biological activity [16] as an authentic specimen [23] of the inactive compound.
A convenient enzymatic‐chemical method for degradation of microamounts of glucose
Authors: Hetey Laszlo , Konitzer Klaus , Voigt Siegfried 
Published: October 2006

AbstractA convenient method for degradation of 1 micromole of glucose is described. The hexose is split enzymatically to triose phosphate. In one half of this solution glyceraldehyde‐3‐phosphate is converted enzymatically to alkali stable 3‐phosphoglycerate, in the other half, dehydroxyacetone phosphate to alkali stable glycerol‐3‐phosphate. In each sample the enzymatically unconverted triose phosphate is hydrolized by alkali to lactic acid which is oxidized by ceriumIV to acetaldehyde and carbon dioxide. Acetaldehyde is degraded further to iodo form and formic acid. The latter is oxidized to carbon dioxide.The omitting laborious chromatographic separation procedurs as well as the isolation of degradation products by two step microdiffusion in a single vessel and their trapping by reagents directly applicable for photometric quantification and measurement of radioactivity makes the procedure time saving and easily performable. These advantages compensate for the loss of 50% of glucose carbon.
Synthesis of some symmetrically deuterated cyclohexanones
Authors: Lompa‐Krzymien Ludmila , Leitch L. C. 
Published: October 2006

AbstractThe series of deuterated cyclohexanones shown in Fig. 1 were synthesized for spectroscopic needs. The NMR spectra of the intermediates employed were measured and the assignments of the various CH2 groups have been made.
A synthesis of 25‐hydroxycholecalciferol‐(26, 27‐3H)
Authors: Bell Philip A. , Scott W. Peter 
Published: October 2006

AbstractThe synthesis of 25‐hydroxycholecaleiferol‐(26, 27‐3H) is described. 25‐Oxo‐27‐norcholesta‐5, dien‐3β‐yl acetate is converted photochemically to 25‐oxo‐27‐norcholecalciferol‐3‐acetate, which is then reacted with tritiated methylmagnesium iodide and subsequently saponified to give 25‐hydroxycholecalciferol‐(26, 27‐3H).
Synthese von DL‐1‐(3′‐hydroxyphenyl)‐2‐aminoäthanol‐hydrochlorid‐(2‐14C [norfenefrin HCL, novadral®]
Authors: Vollmer K.‐O , Liedtke B. 
Published: October 2006

AbstractDL‐1‐(3′‐Hydroxyphenyl)‐2‐aminoäthanol‐hydrochlorid‐ (2‐14C) wurde ausgehend von Kupfercyanid‐14C in einer 2‐Stufen‐Synthese mit guter Ausbeute dargestellt.Dieser Syntheseweg ist auch zur 14C‐Markierung anderer 1‐Aryl‐2‐aminoäthanole in Position 2 gut geeignet.
A simplified biological synthesis of labeled cholesteryl esters
Authors: Kothari Himanshu V. , Carlton Janet S. , Kritchevsky David 
Published: October 2006

AbstractA simplified procedure is described for the synthesis and purification of labelled cholesteryl esters. The esters are synthesized enzymatically from (4‐14C) cholesterol and free fatty acids.The separation of the lipids from aqueous medium is simplified by lyophilizing the reaction mixture at equilibrium. The lipid components of the freeze‐dried powder are separated by silicic acid chromatography. The radiochemical purity of the product was shown to be greater than 98%.
Synthesis of tritium and carbon‐14 labeled 1, 3‐dioxolanes
Authors: Hsi Richard S. P. , Thomas Richard C. 
Published: October 2006

AbstractCondensation of dimethoxdipheny Lmethane14C (III) with the levortatory (IIa) and dextrorotatory (IIb) isomers of 2‐(2‐piperidyl) ‐1, 2‐ethamediol hydrochloride, obtained respectively by hydrolysis from the d and 2 isomers (Ia and Ib) of the lower melting racemate of 2, 2‐diphenyl‐4‐(2‐piperidyl)‐1, 3‐dioxolane hydrochloride, produces the carbon‐14 labeled dioxolanee Ic and Id with retention of configruation at the asymetric carbon atoms. Stepwise reduction of 2,2‐dipheny 1‐4‐(1‐benzyl‐1‐2‐pyridy 1)‐1, 3‐dioxolane. The lower melting racemate was isolated as ists di‐tartaric acid salt (If) and resolved to give optically active tritium‐labeled dixolanes Ig and Ih.
Synthesis of carbon‐14 labeled 1, 4‐benzodiazepines
Authors: Hsi Richard S. P. 
Published: October 2006

AbstractReaction of 7‐chloro‐1, 3‐dihydro‐5‐phenyl‐2H‐1, 4‐benzodiazepine ‐2‐thione (Ia) and 7‐chloro‐5‐(2‐chlorophenyl)‐1, 3‐dihydro‐2H, 1, 4‐benzodiazepine‐2‐thione (Ib) with hydrazine produces. respectively, 7‐chloro‐5‐phenyl‐3H‐1, 4‐benzo‐diazepin‐2‐yl hydrazin (IIa) and 7‐chloro‐5(2‐chlorphenyl)‐3H‐1, 4‐benzodiaze‐pin‐d‐ylhydrazine (IIb). Acetylation of IIa and IIb with N‐acetyl ‐ 114C‐imida‐zole affords acetic acid‐1‐14C 2‐(7‐chloro‐5‐phenyl‐3H‐1, 4‐benzodiazenpin‐2‐yl) hydrazide (IIIa) and acetic acid‐1‐14C 2‐[7‐chloro‐5‐(2‐chlorphenyl) ‐3H‐1, 4‐benzodiazepine‐2‐yl] hydrazide (IIIb). Compounds IIIa and IIIb are thermally cyclised to give 8‐chloro‐1‐methyl‐6‐phenyl‐4H‐s‐triazol [4, 3] [1, 4] benzodiase‐pine‐1‐14c (IVa) and 8‐chloro‐6 (2‐chlorophenyl)‐1‐methyl‐4H‐s‐trizolo[4, 3‐a] ‐[1, 4] benzodiazepine ‐1‐14C (IVb).
A simple synthesis of 2, 6‐diaminopimelic‐/ 1, 7‐ 14C/acid
Authors: Arendt A. , Kolodziejczyk A. 
Published: October 2006

AbstractA convenient method of synthesis of 2, 6‐diaminopinelic / 1, 7 14C / acid / DAP / has been elaborated. Glutaric aldehyde and K14CN produced the dicyanhydrine which was converted without izolation into the dihydantoine derivative of DAP by treatment with NH4HCO3. Hydrolisis /H2So4 / and removal of sulphate ions gave the crystalline, chromatographically pure DAP /1, 7‐14C/ of spec. activity 4, 42 mCi / mole. The radichemical yield of the synthesis was 56%.
Markierte verbindunagen XV(1). Hexachlor‐cyclopentadien‐(14C) aus hexachlorpropen‐(1, 3‐14C) und cis‐1, 2‐dichlorathylen
Authors: Zörkendörfer Eckhard 
Published: October 2006

AbstractStarting with Hexachloropropene‐(1, 3‐14C) and cis‐1.2‐Dichloroethylene Hexachloro‐cyclopentadiene‐(1. 2. 3. 4. 5‐14C) is synthesized.
The study of gamma‐radiolysis and beta‐autoradiolysis of aqueous solutions of thymidine and uridine
Authors: Kopoldova J. , Dedkova V. 
Published: October 2006

AbstractThe effect of external gamma‐ and internal beta ‐irradiation on the aqueous solutions of unlabelled and 3H labelled preparations of thymidine and uridine was investigated within the concentration range 10−4 ‐ 2.10−2M. From these investigations corresponding D/50 and Gi(‐M) values of labelled and unlabelled preparations obtained in very dilute solutions (up to 5.103 ‐ 10−2M) were discussed.
Enzymic reactions in heterogeneous phase, preparation of 17a, 20β, 21‐trihydroxypregn‐4 [14C] en‐3, 11‐dione
Authors: Cremonesi Pietro , Casellato Maria Maddalena 
Published: October 2006

AbstractThe preparation of 17a, 208, 21‐trihydroxypregn‐4 [14C] en‐3, 11‐dione, in quantitative yields, has been achieved u‐sing enzymic reduction of cortisone [14C] in water‐organic solvent heterogeneous system. Since small volumes and little amount of enzyme are required to carry out the reaction, as comppared to the enzymic preparation using an homogeneous aqueous phase, the methodology is useful for preparative purposes.
Synthese et marouage radiactif de stilbenes triaziniques substitues a caractere lymphataope
Authors: Madelmont J. C. , Veyre A. 
Published: October 2006

AbstractLe marquage par 125I et 131I de stilbènes triaziniques à caractère lymphotrope a été réalisé par fixation de l'acide iodo‐5, amino‐2, benzoique au cours de la synthèse. Les substances préparées permettent de réaliser l'exploration dynamique du système lymphatique et d'obtenir de manière simple des lymphographies indirectes.
Synthesis of 1‐4′ ‐ethylphenoxy‐ 14C (U) ‐6,7 ‐epoxy‐ 3,7 ‐dimethyl‐2 ‐octene. A juvenile hormone analog
Authors: Kalbfeld J. , Hoffman L. J. , Chan J. H. , Hermann D. A. 
Published: October 2006

AbstractThe preparation of 1‐4′ ethylphenoxy‐ 14C(U)‐6, 7‐ epoxy ‐ 3, 7‐dimthyl‐2‐octene (1, 2) involved a single reaction wherein 4‐ethlphenol‐14C(U) (3) was mixed with 1‐chloro‐6, 7‐epoxy‐3, 7‐dimithyl‐2‐octene in an acetone water solution at reflux lu‐sing potassium carbonate as a hydrogen chloride acceptor. Althoug this juvenile hormone analog (JHA) normally shows good shelf stabilety, the quality of the labeled material which had been purified by Colum Chromatography deterio‐rated significantly when stored neat for a period of 17 days.