bluuebunny/crossref_metadata_2025_split huggingface dataset:
Repeated endovascular approaches achieve successful complete remodelling for type IIIb acute aortic dissection
Authors: Matsuura Makoto , Kuroyanagi Satoshi , Kobayashi Masaaki , Komooka Masatoshi 
Published: April 2024

Abstract
Thoracic endovascular repair for type IIIb aortic dissection results in the disappearance of false lumen perfusion in the abdominal aorta in only about 20% of cases, with concern for expansion in the long term. Staged endovascular therapy with intervention on all re-entries can lead to complete false lumen thrombosis and remodelling of the entire aorta. This approach could be an option in cases in which long-term expansion is anticipated.
Evaluating energy, exergy and economic aspects of a CO
2
-free Kalina cycle cogeneration system with various solar collectors
Authors: Rad Hima Nikafshan , Ghasemi Amir , Akrami Mohammad , Golizadeh Farid 
Published: April 2024

Abstract
This study meticulously evaluates a Kalina cycle system, adeptly designed for the simultaneous generation of heat, power and cooling. Examining the system from energy, exergy and economic perspectives, the research analyzes the performance of various solar thermal collectors: parabolic trough collectors (PTCs), linear Fresnel reflector, dish-based systems and vacuum tubes (VTs). Among these, the PTC stands out, excelling in energy and exergy efficiency while ensuring cost-effectiveness and minimal system losses. The research also explores the impact of component adjustments on heat, power and cooling production rates. Notably, it identifies the VT collector as the most prominent in terms of exergy destruction and associated costs, with figures reaching 11.07 MW and 159 100 $/year, respectively, offering valuable insights for enhancing the system’s efficiency and economic viability.
Temporal dynamics of genetic parameters and SNP effects for performance and disorder traits in poultry undergoing genomic selection
Authors: Richter Jennifer , Hidalgo Jorge , Bussiman Fernando , Breen Vivian , Misztal Ignacy , Lourenco Daniela 
Published: April 2024

Abstract
Accurate genetic parameters are crucial for predicting breeding values and selection responses in breeding programs. Genetic parameters change with selection, reducing additive genetic variance and changing genetic correlations. This study investigates the dynamic changes in genetic parameters for residual feed intake (RFI), gain (GAIN), breast percentage (BP), and femoral head necrosis (FHN) in a broiler population that undergoes selection, both with and without the use of genomic information. Changes in single nucleotide polymorphism (SNP) effects were also investigated when including genomic information. The dataset containing 200,093 phenotypes for RFI, 42,895 for BP, 203,060 for GAIN, and 63,349 for FHN was obtained from 55 mating groups. The pedigree included 1,252,619 purebred broilers, of which 154,318 were genotyped with a 60K Illumina Chicken SNP BeadChip. A Bayesian approach within the GIBBSF90 + software was applied to estimate the genetic parameters for single-, two-, and four-trait models with sliding time intervals. For all models, we used genomic-based (GEN) and pedigree-based approaches (PED), meaning with or without genotypes. For GEN (PED), heritability varied from 0.19 to 0.2 (0.31 to 0.21) for RFI, 0.18 to 0.11 (0.25 to 0.14) for GAIN, 0.45 to 0.38 (0.61 to 0.47) for BP, and 0.35 to 0.24 (0.53 to 0.28) for FHN, across the intervals. Changes in genetic correlations estimated by GEN (PED) were 0.32 to 0.33 (0.12 to 0.25) for RFI–GAIN, −0.04 to −0.27 (−0.18 to −0.27) for RFI–BP, −0.04 to −0.07 (−0.02 to −0.08) for RFI–FHN, −0.04 to 0.04 (0.06 to 0.2) for GAIN–BP, −0.17 to −0.06 (−0.02 to −0.01) for GAIN–FHN, and 0.02 to 0.07 (0.06 to 0.07) for BP–FHN. Heritabilities tended to decrease over time while genetic correlations showed both increases and decreases depending on the traits. Similar to heritabilities, correlations between SNP effects declined from 0.78 to 0.2 for RFI, 0.8 to 0.2 for GAIN, 0.73 to 0.16 for BP, and 0.71 to 0.14 for FHN over the eight intervals with genomic information, suggesting potential epistatic interactions affecting genetic trait architecture. Given rapid genetic architecture changes and differing estimates between genomic and pedigree-based approaches, using more recent data and genomic information to estimate variance components is recommended for populations undergoing genomic selection to avoid potential biases in genetic parameters.
Timing of nanocrystalline silver-based dressing application: a retrospective single-center pediatric cohort study
Authors: Thibedeau Marshall , Fish Joel , Kelly Charis , Wenskus Julia , Zuccaro Jennifer , Gus Eduardo 
Published: April 2024

Abstract
Recent evidence has demonstrated that silver has anti-inflammatory properties that are independent of the known antimicrobial ones. In our current model of care, nonadherent, nonsilver dressings are applied for acute presentations of pediatric partial-thickness burn injuries. The wounds are re-assessed after the progression phase (48-72 hours after injury), and silver dressings are applied. However, when logistical obstacles prevent re-assessment within the 48- to 72-hour window, nanocrystalline silver-based dressings are applied on presentation. The objective of this study was to test our model of care. We hypothesized that immediate application (&lt;24 hours after injury) of nanocrystalline silver-based dressings would reduce surgical interventions. This was a retrospective single-center cohort study. All patients &lt;18 years old treated at a pediatric burn center for acute partial-thickness burn injuries between January 1, 2020, and December 31, 2021, were included. Multivariable logistic regression was used to compare surgical treatment rates between patients with different timing of nanocrystalline silver-based dressing application. Four hundred and seventy-six patients were included for analysis. One hundred and four patients (21.8%) had nanocrystalline silver-based dressings and 372 (78.2%) had non-silver, non-adherent dressings applied within 24 hours of injury. Multivariable logistic regression identified 3 statistically significant variables as predictors for surgical treatment: age (odds ratio [OR] = 1.14, 95% CI [1.06-1.23]), TBSA (OR = 1.15, 95% CI [1.06-1.25]), and burns to buttocks/lower extremity (OR = 2.39, 95% CI [1.26-4.53]). Immediate (&lt;24 hours after injury) application of nanocrystalline silver-based dressings does not affect surgical treatment rate in pediatric patients with partial-thickness burns.
Age-stage, two-sex life table, and population projection of Ostrinia furnacalis (Lepidoptera: Crambidae) at different temperatures
Authors: Hu Xiaohua , Wang Zhenying , He Kanglai , Xie Haicui , Wang Yueqin 
Published: April 2024

Abstract
Ostrinia furnacalis (Guenée) (Lepidoptera: Crambidae), a highly destructive pest in Asia, poses a significant threat to maize production by causing substantial yield losses. However, there is a lack of information regarding the impact of temperature variations on its population dynamics and the age-stage and two-sex life table. This study aimed to investigate the impact of 4 temperatures (20 °C, 24 °C, 28 °C, 32 °C) on the development, reproduction, and survival of O. furnacalis under controlled laboratory conditions. Our results revealed that O. furnacalis successfully developed, survived, and laid eggs across the tested temperatures (20–32 °C). The shortest developmental duration for all immature stages was observed at 32 °C. Conversely, increasing temperatures led to decreased longevity. Among the temperatures tested, 28 °C proved to be optimal for O. furnacalis, exhibiting the highest intrinsic rate of increase, finite rate of increase, and net reproductive rate. Our findings indicate that O. furnacalis thrives within a wide temperature range of 20–32 °C, with 28 °C being the most favorable for reproduction. These insights are crucial for predicting population dynamics under diverse climatic conditions and developing effective control strategies against O. furnacalis. This study enhances our understanding of O. furnacalis’ life-history traits and provides valuable information for targeted pest management approaches.
Female patent attorneys and movements around the profession: achieving non-gendered decision-making
Authors: Lai Jessica C , Geldenhuys Ronelle , Khajeh Tabari Maryam , Summerfield Mark 
Published: April 2024

Abstract
Female patent attorneys face multiple layers of bias and discrimination. This article uses qualitative and quantitative data to analyse the experiences of female patent attorneys in Australia and New Zealand and their movements around the profession. Through interviews with 53 patent attorneys and an analysis of over 5 years of data on registered patent attorneys, we examine the experiences of women and how this can affect their decision to move to in-house roles, set up their own entities or move to smaller firms. While noting that women appear to face bias regardless of where they practice, the article concludes that the particular issues mothers face represent a key factor in why women are disproportionately over-represented in in-house roles. The issues also constitute a motivation for many women to set up their own entities and to move firms (though not necessarily from a larger to a smaller firm).
Farmers’ perceptions of integrated desert locust management: a case study in Isiolo and Meru Counties of Kenya
Authors: Lumumba Brian Omondi , Otieno David Jakinda , Nyikal Rose Adhiambo 
Published: April 2024

Abstract
The destructive nature of desert locust invasions in terms of reduced food security and loss of agricultural income necessitates effective control strategies. While chemical spraying is effective, it is harmful to the environment, human, and animal health. Therefore, an alternative is the implementation of an integrated desert locust management (IDLM) approach that entails surveillance and early warning systems, rational combination of chemicals, biological measures, and indigenous control methods. Adopting IDLM depends on an understanding of human behavior and perceptions as an avenue for disseminating information for effective control. However, there is limited knowledge of the drivers of farmers’ perceptions of IDLM. This study sought to fill the above knowledge gap by applying the principal component analysis method to develop a composite index that was subsequently used in a regression analysis of data collected from a sample of 391 farmers in Isiolo and Meru counties in Kenya. Descriptive results showed that informal sources and channels were the main sources of desert locust information, and most farmers held positive or neutral perceptions. The regression analysis results highlighted the role of formal and informal sources of information, private land ownership, and previous shocks in influencing farmers’ perceptions of integrated desert locust management. The study recommends targeted messaging of desert locust management approaches through coordinated surveillance and timely response by national and international agencies, empowering community leaders as the key entry point, and building local capacity for accurate observation and timely reporting of invasions as measures towards sustainable desert locust control efforts.
Organic management of the invasive swede midge (Diptera: Cecidomyiidae) on Brassica vegetables: multiple dead ends necessitate novel approaches
Authors: Hodgdon Elisabeth A , Stratton Chase A , Hoepting Christine A , Campbell Andrea E M , Gradish Angela E , Evans Braden G , Hallett Rebecca H , Chen Yolanda H 
Published: April 2024

Abstract
The distinctive biology and ecology of the invasive swede midge, Contarinia nasturtii Kieffer (Diptera: Cecidomyiidae), render organic management in North America particularly challenging, necessitating the search for novel out-of-the box approaches to control it. Native to Eurasia, this pest was first confirmed in North America in 2000 and has since spread to several states and provinces in the United States and Canada. As a galling midge, swede midge feeding causes distorted growth in Brassica (Brassicales: Brassicaceae) vegetables, resulting in major losses of marketable produce. While conventional growers typically use systemic insecticides for plant protection early in the season, equivalent approaches for organic production do not exist. The lack of effective organic management approaches for swede midge has resulted in devastating losses for heading Brassica vegetables, which are the most sensitive to midge feeding. Here, we review over 2 decades of research focused on developing organic approaches to manage swede midge. To encourage more rapid progress on swede midge management, we believe that it is important to review the widest array of work, including recent publications as well as our unpublished research. We conclude by highlighting the most promising strategies that should be utilized on farms and explored further for organic management of swede midge in vegetable crops.
VIBES: a workflow for annotating and visualizing viral sequences integrated into bacterial genomes
Authors: Copeland Conner J , Roddy Jack W , Schmidt Amelia K , Secor Patrick R , Wheeler Travis J 
Published: April 2024

Abstract
Bacteriophages are viruses that infect bacteria. Many bacteriophages integrate their genomes into the bacterial chromosome and become prophages. Prophages may substantially burden or benefit host bacteria fitness, acting in some cases as parasites and in others as mutualists. Some prophages have been demonstrated to increase host virulence. The increasing ease of bacterial genome sequencing provides an opportunity to deeply explore prophage prevalence and insertion sites. Here we present VIBES (Viral Integrations in Bacterial genomES), a workflow intended to automate prophage annotation in complete bacterial genome sequences. VIBES provides additional context to prophage annotations by annotating bacterial genes and viral proteins in user-provided bacterial and viral genomes. The VIBES pipeline is implemented as a Nextflow-driven workflow, providing a simple, unified interface for execution on local, cluster and cloud computing environments. For each step of the pipeline, a container including all necessary software dependencies is provided. VIBES produces results in simple tab-separated format and generates intuitive and interactive visualizations for data exploration. Despite VIBES’s primary emphasis on prophage annotation, its generic alignment-based design allows it to be deployed as a general-purpose sequence similarity search manager. We demonstrate the utility of the VIBES prophage annotation workflow by searching for 178 Pf phage genomes across 1072 Pseudomonas spp. genomes.
Teams in Transition: Increasing Role of Advanced Practice Providers in Antimicrobial Use and Infectious Diseases Consultation
Authors: Perez Reinaldo , Yarrington Michael E , Deri Connor R , Smith Michael J , Hayes Jillian , Wrenn Rebekah H , Moehring Rebekah W 
Published: April 2024

Abstract

Background
Advanced practice providers (APPs) have taken on increasing responsibilities as primary team members in acute care hospitals, but the impact of this practice shift on antimicrobial prescribing and infectious diseases (ID) consultation requests is unknown. Here we describe longitudinal trends in antimicrobial days of therapy (DOT) and ID consultation by attributed provider type in 3 hospitals.

Methods
We performed a retrospective time series analysis of antimicrobial use and ID consultation from July 2015 to June 2022 at a major university hospital and 2 community hospitals. We evaluated antimicrobial DOT and ID consultation over time and assessed attribution to 3 groups of providers: attending physicians, trainees, and APPs. We used multinomial logistic regression to measure changes in percentage of DOT and ID consultation across the clinician groups over time using physicians as the referent.

Results
Baseline distribution of antimicrobial DOT and ID consultation varied by practice setting, but all subgroups showed increases in the proportion attributable to APPs. Large increases were seen in the rate of ID consultation, increasing by &gt;30% during the study period. At our university hospital, by study end &gt;40% of new ID consults and restricted antimicrobial days were attributed to APPs.

Conclusions
Hospitals had differing baseline patterns of DOT attributed to provider groups, but all experienced increases in DOT attributed to APPs. Similar increases were seen in changes to ID consultation. APPs have increasing involvement in antimicrobial use decisions in the inpatient setting and should be engaged in future antimicrobial stewardship initiatives.
Real-World Effectiveness of Intravenous and Oral Antibiotic Stepdown Strategies for Gram-Negative Complicated Urinary Tract Infection With Bacteremia
Authors: Veillette John J , May Stephanie S , Alzaidi Sameer , Olson Jared , Butler Allison M , Waters C Dustin , Jackson Katarina , Hutton Mary A , Webb Brandon J 
Published: April 2024

Abstract

Background
Robust data are lacking regarding the optimal route, duration, and antibiotic choice for gram-negative bloodstream infection from a complicated urinary tract infection source (GN-BSI/cUTI).

Methods
In this multicenter observational cohort study, we simulated a 4-arm registry trial using a causal inference method to compare effectiveness of the following regimens for GN-BSI/cUTI: complete course of an intravenous β-lactam (IVBL) or oral stepdown therapy within 7 days using fluoroquinolones (FQs), trimethoprim-sulfamethoxazole (TMP-SMX), or high-bioavailability β-lactams (HBBLs). Adults treated between January 2016 and December 2022 for Escherichia coli or Klebsiella species GN-BSI/cUTI were included. Propensity weighting was used to balance characteristics between groups. The 60-day recurrence was compared using a multinomial Cox proportional hazards model with probability of treatment weighting.

Results
Of 2571 patients screened, 759 (30%) were included. Characteristics were similar between groups. Compared with IVBLs, we did not observe a difference in effectiveness for FQs (adjusted hazard ratio, 1.09 [95% confidence interval, .49–2.43]) or TMP-SMX (1.44 [.54–3.87]), and the effectiveness of TMP-SMX/FQ appeared to be optimal at durations of &gt;10 days. HBBLs were associated with nearly 4-fold higher risk of recurrence (adjusted hazard ratio, 3.83 [95% confidence interval, 1.76–8.33]), which was not mitigated by longer treatment durations. Most HBBLs (67%) were not optimally dosed for bacteremia. Results were robust to multiple sensitivity analyses.

Conclusions
These real-world data suggest that oral stepdown therapy with FQs or TMP-SMX have similar effectiveness as IVBLs. HBBLs were associated with higher recurrence rates, but dosing was suboptimal. Further data are needed to define optimal dosing and duration to mitigate treatment failures.
BCAR4 facilitates trastuzumab resistance and EMT in breast cancer via sponging miR‐665 and interacting with YAP1
Authors: Ye Xingming , Liu Qinying , Qin Xin , Ma Yijing , Sheng Qingsong , Wu Xiufeng , Chen Shanshan , Huang Lijie , Sun Yang 
Published: April 2024

AbstractBreast cancer antiestrogen resistance 4 (BCAR4) has been suggested that can modulate cell behavior, resulting in tumorigenesis and chemoresistance. However, the underlying mechanisms of BCAR4 in trastuzumab resistance (TR) is still elusive. Here, we explored the function and the underlying mechanism of BCAR4 involving in TR. We found that BCAR4 is significantly upregulated in trastuzumab‐resistant BC cells. Knockdown of BCAR4 could sensitize the BC cells to trastuzumab and suppress epithelial–mesenchymal transition (EMT). Mechanically, BCAR4 promotes yes‐associated protein 1 (YAP1) expression by competitively sponging miR‐665, to activated TGF‐β signaling. Reciprocally, YAP1 could occupy the BCAR4 promoter to enhance its transcription, suggesting that there exists a positive feedback regulation between YAP1 and BCAR4. Targeting the BCAR4/miR‐665/YAP1 axis may provide a novel insight of therapeutic approaches for TR in BC.
Hypobaric hypoxia aggravates osteoarthritis via the alteration of the oxygen environment and bone remodeling in the subchondral zone
Authors: Li Qianhao , Yang Zhouyuan , Zhu Mengli , Zhang Wanli , Chen Liyile , Chen Hongying , Kang Pengde 
Published: April 2024

AbstractA high prevalence of osteoarthritis (OA) has been observed among individuals living at high altitudes, and hypobaric hypoxia (HH) can cause bone mass and strength deterioration. However, the effect of HH on OA remains unclear. In this study, we aimed to explore the impact of HH on OA and its potential mechanisms. A rat knee OA model was established by surgery, and the rats were bred in an HH chamber simulating a high‐altitude environment. Micro‐computed tomography (Micro‐CT), histological analysis, and RNA sequencing were performed to evaluate the effects of HH on OA in vivo. A hypoxic co‐culture model of osteoclasts and osteoblasts was also established to determine their effects on chondrogenesis in vitro. Cartilage degeneration significantly worsened in the HH‐OA group compared to that in the normoxia‐OA (N‐OA) group, 4 weeks after surgery. Micro‐CT analysis revealed more deteriorated bone mass in the HH‐OA group than in the N‐OA group. Decreased hypoxia levels in the cartilage and enhanced hypoxia levels in the subchondral bone were observed in the HH‐OA group. Furthermore, chondrocytes cultured in a conditioned medium from the hypoxic co‐culture model showed decreased anabolism and extracellular matrix compared to those in the normoxic model. RNA sequencing analysis of the subchondral bone indicated that the glycolytic signaling pathway was highly activated in the HH‐OA group. HH‐related OA progression was associated with alterations in the oxygen environment and bone remodeling in the subchondral zone, which provided new insights into the pathogenesis of OA.