bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Comparative Analysis of Transitional Analgesia with Oxycodone and Sufentanil in Patients with Early Esophageal Carcinoma Undergoing Endoscopic Submucosal Dissection
Authors: Gu Meirong , Chen Wenyi , Wu Xiaowen , Wu Tianjun , Zhang Xin , Qian Yiling 
Published: March 2024

Abstract
Background: Postoperative pain management is a critical consideration in patients undergoing endoscopic submucosal dissection (ESD) for early esophageal carcinoma. Conventional transitional analgesia methods involve the administration of either oxycodone or sufentanil. However, the efficacy of oxycodone in the context of patients with early esophageal carcinoma undergoing ESD under general anesthesia remains uncertain. This study aims to compare the postoperative analgesic effects of oxycodone and sufentanil in patients undergoing ESD for early esophageal carcinoma patients under general anesthesia.
Methods: In this randomized double-blind controlled study, 86 patients scheduled for ESD surgery under general anesthesia were enrolled. They were randomly assigned to the oxycodone group (O group, n = 29), sufentanil group (S group, n = 30), or normal saline group (N group, n = 26) using a double-blind method. Thirty minutes before the end of the surgery, patients in the O group received oxycodone (0.1 mg/kg), those in the S group received sufentanil (0.1 μg/kg), and those in the N group received an identical volume of normal saline. Various parameters, including general patient conditions, intraoperative anesthetic medication, vital sign variations throughout the perioperative period, postoperative recovery duration, decannulation time, and adverse reactions during the recovery period were meticulously recorded. Visual Analog Scale (VAS) scores at rest and during movement at 0 h, 12 h, and 24 h post-surgery, along with the incidence of pain relief and malignant vomiting, were also documented.
Results: No statistically significant differences were observed in general patient conditions, intraoperative anesthetic dosages, or vital sign changes among the three groups. However, patients in the O group exhibited significantly prolonged recovery and decannulation times compared to the S and N groups,without impeding overall recovery. Statistically significant differences in adverse reactions during the recovery period were observed (P<0.05). Furthermore, patients in the O group demonstrated decreased VAS scores at 0 h, 12 h, and 24 h post-surgery, regardless of rest or movement, compared to the S and N groups. Although VAS scores in the S group were significantly reduced at postoperative 0 h and 12 h at rest compared to the N group, no significant differences were noted in the reduction of VAS scores during movement. The incidence of severe vomiting did not significantly differ among the three postoperative groups.
Conclusion: When compared with sufentanil, oxycodone exhibited more prolonged and comprehensive analgesic effects in patients undergoing esophageal ESD under general anesthesia, with no significant side effects. These findings contribute to our understanding of transitional analgesia strategies in this specific patient population.
Relationship of Physical Activity to depression：Coping Styles and Loneliness Mediating Effects among College Students
Authors: Fu Huaying , Guo Siqiang , Guo Kelei 
Published: March 2024

Abstract
Purpose: To explore the relationship between physical activity and depression among college students and the mediating role of coping styles and loneliness in the relationship.
Methods: A stratified whole group sampling method was used to survey 1112 college students using the Physical Activity Scale, Depression Scale, Coping Styles Scale, and Loneliness Scale.
Results: (1) Physical activity was significantly negatively correlated with depression (r =-0.51), and the direct path of physical activity on depression was significant (β= -0.21, t= -8.418 , p＜0.01), (2) Physical activity positively predicted coping styles (β= 0.39，t= 14.202，p＜0.01) and negatively predicted loneliness (β= -0.40，t= -15.039，p＜0.01), and Coping styles significantly and negatively predicted depression (β= -0.28，t= -10.281，p＜0.01) and loneliness (β= -0.41，t= -17.187，p＜0.01), and Loneliness significantly and positively predicted depression (β= 0.26，t= 10.289，p＜0.01).
Conclusion: Physical activity can not only directly affect depression, but also indirectly through the separate mediating effects of coping styles and loneliness, as well as the chain mediating effects of the two.
The Influence of Long-Term Football Training on Neural Representation of Action Verb Semantics
Authors: Wang Jian , Mou Hong , Liu Likai , Zhou Chenglin , Wang Yingying 
Published: March 2024

Abstract
The debate on whether sensorimotor experience can modulate the neural representation of action verbs is ongoing. This study investigated whether extensive football training alters the neural patterns representing action verbs in sensorimotor and related regions, focusing on effector-specific changes. Specifically, we assessed if training experiences of specific effectors influence semantic neural representation patterns in corresponding sensorimotor areas. Employing functional magnetic resonance imaging (fMRI), subjects (both football experts and novices) engaged in an implicit reading task, silently reading action verbs and identifying the involved body part. We used multivariate pattern analyses (MVPA) to classify effector-related information and assess decoding accuracy in the right paracentral gyrus (PCG) and left postcentral gyrus (PoCG) associated with action execution, and the left inferior parietal lobule (IPL) and left precentral gyrus (PrG) linked to action observation. Our findings revealed that both experts and novices could decode effector information from action verbs across all regions of interest. Notably, distinct activation patterns between experts and novices were observed in execution regions (PCG and PoCG), but not in observation regions (IPL and PrG), highlighting a specialized neural adaptation in PCG and PoCG. Furthermore, a significant correlation between decoding accuracy and training duration was found among football experts. Univariate analysis showed that experts exhibited higher activation intensity when processing foot-related verbs. In summary, our results suggest that long-term football training effector-specifically modulates the neural representation of action verbs in sensorimotor and related areas, predominantly driven by motor rather than sensory experience.
Land use changes and climate parameters assessments in a tropical highland region of Cameron Highlands, Malaysia
Authors: Arumugam Agilambigai , Sigid Muhammad Fikri , Ab Rahman Azimah , Fadhullah Widad 
Published: March 2024

ABSTRACT

Tropical highland regions are susceptible to climate change and natural disasters due to their geographical location and hilly terrain. The objectives of this study are to determine land use land cover (LULC) changes in the Cameron Highlands and analyse the climatic parameters of the Cameron Highlands. This study integrates LULC analysis using remote sensing techniques and 10-year climatic parameters data to evaluate the impact of climate variability on the sustainability of the Cameron Highlands. Based on the validation results, the overall accuracy of LULC was 95.42% in 2016, 96.60% in 2018, and 97.40% in 2020. The results show an 18% rise in agriculture, a 16% increase in urban growth, and an 8.14% decline in forest coverage in Tanah Rata and Ringlet, Cameron Highlands, from 2016 to 2020. The Mann -Kendall and Sen slope indicated a statistically significant increasing trend in rainfall (Kendall's Tau, z = 0.102, p &lt; 0.0001 and Sen value= 0.131, p &lt; 0.001, respectively) and temperature (Kendall's Tau, z = 0.151, p &lt; 0.001 and Sen value = 0.294, p &lt; 0.001, respectively) from 2012 to 2021, increasing the area's susceptibility towards climate change impact and natural disasters. This study highlights the vulnerability of the Cameron Highlands to natural disasters, emphasizing the crucial need for efficient land management in slope areas.
Marine Microalgae Schizochytrium sp. S31: Potential Source for New
Antimicrobial and Antibiofilm Agent
Authors: Hammadi Al-Ogaidi Doaa Abdullah , Karaçam Sevinç , Gurbanov Rafig , Vardar-Yel Nurcan 
Published: March 2024

Background:
The rise of antibiotic-resistant bacteria necessitates the discovery of
new, safe, and bioactive antimicrobial compounds. The antibacterial and antibiofilm activity of
microalgae makes them a potential candidate for developing natural antibiotics to limit microbial
infection in various fields.

Objective:
This study aimed to analyze the antibacterial effect of the methanolic extract of
Schizochytrium sp. S31 microalgae by broth microdilution and spot plate assays.

Methods:
The antibacterial effects of Schizochytrium sp. S31 extract was studied on gramnegative
pathogens, Pseudomonas aeruginosa, Escherichia coli 35218, Klebsiella pneumonia,
which cause many different human infections, and the gram-positive pathogen Streptococcus
mutans. At the same time, the antibiofilm activity of the Schizochytrium sp. S31 extract on Pseudomonas
aeruginosa and Escherichia coli 35218 bacteria were investigated by crystal violet
staining method.

Results:
Schizochytrium sp. S31 extract at a 60% concentration for 8 hours displayed the highest
antibacterial activity against P. aeruginosa, E. coli 35218, and K. pneumonia, with a decrease of
87%, 92%, and 98% in cell viability, respectively. The experiment with Streptococcus mutans
revealed a remarkable antibacterial effect at a 60% extract concentration for 24 hours, leading to
a notable 93% reduction in cell viability. Furthermore, the extract exhibited a dose-dependent
inhibition of biofilm formation in P. aeruginosa and E. coli 35218. The concentration of 60%
extract was identified as the most effective dosage in terms of inhibition.

Conclusion:
This research emphasizes the potential of Schizochytrium sp. S31 as a natural antibacterial
and antibiofilm agent with promising applications in the pharmaceutical sectors. This is
the first study to examine the antibacterial activity of Schizochytrium sp. S31 microalgae using
broth microdilution, spot plate assays, and the antibiofilm activity by a crystal staining method.
The findings of this study show that Schizochytrium sp. S31 has antibacterial and antibiofilm
activities against critical bacterial pathogens.
Formulation and Evaluation of Hard Lozenges by Using Garlic Tincture
Authors: Popli Anmol , Handa Uditi , Kumar Kuldeep , Sharma Prerna , Guarve Kumar , Parmar Ishika , Chhabra Lavish , Nagpal Kajal , Rani Nidhi , Verma Inderjeet 
Published: March 2024

Background:
Lozenges are one of the more well-liked and inventive oral confectionery
products in the market. The lozenges also act as solid medications that are flavored, sweetened, and
meant to be sucked into the mouth/pharynx or held over that cavity. Garlic contains anti-microbial
agents which help to reduce the impact of cough and reduce it.

Aims:
The goal of the current research is to formulate and investigate herbal lozenges by using garlic
tinctures with their antimicrobial action to cure the infection caused by microbes.

Methods:
Hard lozenges were prepared by Heating and congealing techniques and statistical analysis
was done by using one sample chi-square test (IBM SPSS version 20).

Results:
Hard lozenges were formulated by using garlic tinctures with minimum excipients. According
to ICH recommendations, stability experiments were conducted. According to the stability investigations,
there were no major changes noticed during the period after the one-month stability test. The antimicrobial
activity was studied under different time intervals after 8-72 hours. The inhibition zone
value for the test sample was found to be 0.1-0.5 mm and for the standard sample was noticed from
0.5-0.8 mm, respectively. The statistical test outcome revealed, no remarkable difference shown between
the prepared and the marketed formulation (p>0.05).

Conclusion:
From the present work, it was concluded that the prepared lozenges have similar result
with minimum ingredients as compared to the marketed formulation (Tulsi-ginger lozenges). Hence,
the formulation, testing, and antimicrobial activity for oral use in garlic lozenges were effective.
siRNA Targeting ECE-1 Partially Reverses Pulmonary Arterial Hypertensionassociated
Damage in a Monocrotaline Model
Authors: Blancas-Napoles Citlali Margarita , Cabrera-Becerra Sandra Edith , Sierra-Sánchez Vivany Maydel , Ocampo-Ortega Sergio Adrian , Garcia-Rubio Vanessa Giselle , Romero-Nava Rodrigo , Huang Fengyang , Hong Enrique , Aguilera-Méndez Asdrúbal , Villafaña Santiago 
Published: March 2024

Aims:
The aim of this study was to develop a possible treatment for pulmonary arterial hypertension.

Background:
Pulmonary arterial hypertension (PAH) is a rare disease characterised by a pulmonary arterial pressure greater than 20 mmHg. One of the factors
that contribute to PAH is an increase in the production of endothelin-1, a polypeptide that increases vascular resistance in the pulmonary arteries,
leading to increased pulmonary arterial pressure and right ventricular hypertrophy.

Objective:
The objective of this study was to design, synthesize, and evaluate two siRNAs directed against endothelin-1 in a rat model of PAH induced with
monocrotaline.

Methods:
Wistar rats were administered monocrotaline (60 mg/kg) to induce a PAH model. Following two weeks of PAH evolution, the siRNAs were
administered, and after two weeks, right ventricular hypertrophy was evaluated using the RV/LV+S ratio, blood pressure, weight, and relative
expression of ECE-1 (Endothelin-converting enzyme-1) mRNA (messenger RNA) by RT-PCR (real-time PCR).

Results:
The monocrotaline group showed an increase in the hypertrophy index and in ECE-1 mRNA, as well as a significant decrease in weight compared
to the control group, while in the monocrotaline + siRNA group, a significant decrease was observed in the relative expression of ECE-1 mRNA,
as well as in right ventricular hypertrophy.

Conclusions:
Based on the above information, we conclude that the administration of siRNAs directed to ECE-1 decreases the damage associated with PAH.
Guiding Principles for Adolescent Web-Based Portal Access Policies: Interviews With Informatics Administrators
Authors: Sisk Bryan , Antes Alison L , Bereitschaft Christine , Enloe Madi , Bourgeois Fabienne , DuBois James 
Published: March 2024

Background
Web-based patient portals are tools that could support adolescents in managing their health and developing autonomy. However, informatics administrators must navigate competing interests when developing portal access policies for adolescents and their parents.

Objective
We aimed to assess the perspectives of informatics administrators on guiding principles for the development of web-based health care portal access policies in adolescent health care.

Methods
We interviewed informatics administrators from US hospitals with ≥50 dedicated pediatric beds. We performed a thematic analysis of guiding principles for developing and implementing adolescent portal access policies.

Results
We interviewed 65 informatics leaders who represented 63 pediatric hospitals, 58 health care systems, 29 states, and 14,379 pediatric hospital beds. Participants described 9 guiding principles related to three overarching themes: (1) balancing confidentiality and other care needs, (2) balancing simplicity and granularity, and (3) collaborating and advocating. Participants described the central importance of prioritizing the health and safety of the adolescent while also complying with state and federal laws. However, there were differing beliefs about how to prioritize health and safety and what role parents should play in supporting the adolescent’s health care. Participants also identified areas where clinicians and institutions can advocate for adolescents, especially with electronic health record vendors and legislators.

Conclusions
Informatics administrators provided guiding principles for adolescent portal access policies that aimed to balance the competing needs of adolescent confidentiality and the usefulness of the portal. Portal access policies must prioritize the adolescent’s health and safety while complying with state and federal laws. However, institutions must determine how to best enact these principles. Institutions and clinicians should strive for consensus on principles to strengthen advocacy efforts with institutional leadership, electronic health record vendors, and lawmakers.
MENINGKATKAN MINAT BELAJAR SISWA TERHADAP PEMBELAJARAN IPA MELALUI BUKU DIGITAL FLIPBOOK
Authors: Rajagukguk Suryana , Lubis Wirda Hayatina , Pohan Ade Hermansyah , Ginting Susanna , Silaban Saronom 
Published: March 2024

Kajian ini bermaksud untuk meningkatkan minat belajar siswa dengan menerapkan buku digital flipbook sebagai alternatif belajar yang bersifat inovatif sebagai upaya memanfaatkan minat belajar siswa pada pelajaran IPA terkhusus materi sumber energi. Selain itu, kajian ini juga bermaksud dapat mengurangi beban guru dalam menyajikan informasi dalam pembelajaran karena diwakili dengan adanya buku digital flipbook, dapat mengefektifkan dan mengefisienkan waktu pembelajaran karena tidak harus membawa banyak buku bacaan yang berat, dan dapat membantu memudahkan siswa belajar karena fitur multimedia dapat menjadi tutor. Kajian ini merupakan kajian kuantitatif dengan siswa kelas IV SDN 064992 Kec. Medan Amplas sebanyak 20 sebagai subyek penelitian, data dikumpulkan melalui angket minat belajar siswa yang kemudian dianalisis dengan analisa data kuantitatif. Data kuantitatif yang didapat dari hasil angket minat belajar siswa. Selaras hasil penelitian diperoleh bahwa penggunaan buku digital flipbook mampu meningkatkan minat belajar siswa pada pembelajaran IPA dengan persenatse rerata 90,8% dan kategori sangat baik.
Lo scavo-scuola 2022
Authors: Adornato Gianfranco 
Published: March 2024

La campagna di scavo 2022 si è concentrata sul settore occidentale del santuario, al fine di definire meglio i limiti e le strutture del lato nord occidentale del tempio: la trincea di fondazione dei blocchi corre parallela al lato settentrionale dell'edificio sacro, sebbene il posizionamento dei blocchi sia oggi leggermente diverso. La struttura funge da muro di contenimento e terrazzamento. Nuovi dati archivistici e grafici ci hanno spinto a rivolgere l'attenzione al tempio e alla definizione dello spazio interno: sembra plausibile individuare una sorta di adyton nella parte occidentale della cella; le scale e lo spazio sacro sono stati concepiti fin dalla prima fase dell'edificio. I materiali archeologici provenienti dalla trincea presso l'altare hanno fornito dati significativi sulla cronologia del santuario; inoltre, l'indagine nel settore nord-orientale dell'altare ha fornito ulteriori informazioni sulla tecnica e sulla sequenza di lavorazione del monumento.
Vertebral heart size and vertebral left atrial size reference ranges in healthy Miniature Schnauzers
Authors: Murphy Lisa , Piscitelli Nicole , Solomon Jessica , Szlosek Donald , Nakamura Reid K 
Published: March 2024

Abstract

OBJECTIVE
The inclusion of vertebral heart score (VHS) and, more recently, the inclusion of the vertebral left atrial size (VLAS) in radiographic evaluation have become important screening tools for identifying dogs with occult cardiac disease. Several recent papers have shown there are interbreed variations in the VHS reference range. Our hypothesis is that the Miniature Schnauzer would also have a higher reference range for its VHS.

ANIMALS
The electronic medical records of IDEXX Telemedicine Consultants were searched for Miniature Schnauzers undergoing thoracic radiographs between March 1, 2022, and February 28, 2023.

METHODS
Dogs were included if they had 3 view thoracic radiographs performed and no evidence of cardiopulmonary disease was detected. Dogs with incomplete radiographic studies or cardiac or extracardiac disease were excluded. The VHS and VLAS measurements were performed by 2 board-certified cardiologists independent of one another.

RESULTS
A total of 1,000 radiographs were obtained of which 272 were included for the study. The overall range for the VHS in this cohort was 9.68 to 12.07 with a median of 10.9. For VLAS measurements, a range of 1.71 to 2.4 was documented with a median of 2.0.

CLINICAL RELEVANCE
The VHS for Miniature Schnauzers without cardiac disease was confirmed to be higher than the canine reference range.
Novel presentation of a feline patient with visceral and cervical lymph node hemangiosarcoma
Authors: Goddard Alexandra , Walters Kristine , Campbell Katy 
Published: March 2024

Abstract

OBJECTIVE
To report a novel presentation of feline hemangiosarcoma.

ANIMALS
A 14-year-old spayed female feline patient diagnosed with hemangiosarcoma of the spleen and a cervical lymph node.

CLINICAL PRESENTATION, PROGRESSION, AND PROCEDURES
The patient presented to the emergency service following a 1-week history of lethargy and hiding. Abdominal ultrasound revealed splenomegaly with multiple nodules and peritoneal fluid that was consistent with hemorrhagic effusion.

TREATMENT AND OUTCOME
The patient underwent a routine splenectomy and was started on doxorubicin. Histopathologic evaluation of the spleen confirmed visceral hemangiosarcoma. When the disease showed signs of progression, combination chemotherapy with cyclophosphamide and vincristine was initiated. Four months following presentation, a submandibular lymph node was removed and found to have metastatic hemangiosarcoma. From presentation to euthanasia, the patient survived 205 days.

CLINICAL RELEVANCE
Hemangiosarcoma is a rare cancer in feline patients, with a lack of veterinary literature on its presentation and chemotherapy protocols. The subject of this case report had a novel presentation of hemangiosarcoma and responded favorably to a chemotherapy protocol not previously described for this disease.