bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fluorinated Covalent Organic Framework Membranes Enable High‐Efficiency and Water‐Resistance CO2/N2 Separation
Authors: Zhang Pinyue , Zhang Chi , Zhu Changyan , Dong Junchao , Zhang Hao , Shao Tianci , Ma Dan , Tian Yuyang , Zou Xiaoqin 
Published: February 2025

AbstractMembrane separation is advantageous in mitigating excessive carbon dioxide (CO2) emission of worldwide concern. However, most membranes are vulnerable to water during CO2 separation from combustion disposal gas, resulting in performance deterioration. Water‐resistant covalent organic framework (COF) membranes for efficient CO2 separation from wet gas stream are designed and synthesized. Two COFs termed as COF‐TpPa‐1‐CF3 and COF‐TFBPa‐CF3 are constructed using planar trifluoromethyl‐functionalized monomers; featuring open straight pores, high hydrophobicity, and unique CO2 affinity. Liquid–liquid interfacial polymerization renders the self‐standing COF membranes free of cracks. COF‐TFBPa‐CF3 and COF‐TpPa‐1‐CF3 membranes are able to separate CO2 from N2 under dry and wet conditions; and the former membrane is more resistant against water than the latter one, demonstrated by invariant gas permeation. The COF‐TFBPa‐CF3 membrane exhibits exceptional CO2 permeability (>9000 Barrer) and high CO2/N2 selectivity (>25), superior to other reported COF membranes. Moreover, the selectivity‐permeability product breaks 2008 upper bound. The excellent separation performance, water stability, and high reproducibility promise COF‐TFBPa‐CF3 membrane in practical CO2 separation from post‐combustion gas.
Regulation of Configurational Entropy to Realize Long Cycle Lifespan of High Entropy Alloy Anodes for Potassium Batteries
Authors: Zhang Ruiying , Xue Huichun , Du Daoguang , Shen Yue , Zheng Jia , Li Changwei , Feng Zhongmin , Sun Ting 
Published: February 2025

AbstractHigh entropy alloys (HEAs) with entropy‐driven stabilization are attractive in potassium‐ion batteries (PIBs); however, they suffer from phase segregation due to the disparity of versatile components. Confining multifarious metals into the same lattice using ligands with full‐coordination abilities allows for delicate control at the nanoscale level and thus decreases atom diffusion. This chemical synthesis can suppress phase segregation and realize HEAs for PIB anodes. Herein, a new MnCoNiCuZn‐based HEA nanoparticle encapsulated within nitrogen‐doped carbon (HEA‐NPs@NC) is fabricated for PIB anodes. The flexible chlorhexidine is selected due to its long chain, large steric bulkiness, abundant neutral tetradentate donors, and large coordination ability. The high entropy effect and the “cocktail” effect of HEA‐NPs@NC allow for tailoring electrochemical functionalities, including multiple K+ transport paths, good conductivity, and entropy stability. The HEA‐NPs@NC anode achieves a long lifespan of over 3000 cycles, impressive capacity (513 mAh g−1), and high‐rate performance (202 mAh g−1 at 5 A g−1). The ex situ characterizations and density functional theory calculations elucidated the HEA acts as an “atomic composite” and forms interstitial metallic solid solutions with K due to the interaction of constituent elements.
Precision Molecular Engineering of Carbon Nitride for Efficient and Selective Photoreduction of CO2 to C2H6 in Pure Water
Authors: Chen Zihe , Ding Guixiang , Wang Zhaoqiang , Xiao Yin , Liu Xin , Chen Lihui , Li Chunxue , Huang Hongwei , Liao Guangfu 
Published: February 2025

AbstractPhotocatalytic CO2 reduction into high‐value C2+ products such as C2H6 is of great importance but challenging due to their multi‐electron steps and high energy barrier of C─C coupling. Moreover, improving its solar‐to‐chemical (STC) energy conversion efficiency in pure water beyond the current 1% empirical value is also a significant challenge. Herein, graphite carbon nitride (g‐C3N4) nanosheets with controllable carbon (C) doping and nitrogen (N) vacancies (PCCN‐x) are designed through a biochar‐tailored protocol for efficiently and selectively photo‐converting CO2 into C2H6. The optimal PCCN‐10 photocatalyst enables the achievement of an exceptional C2H6 activity of 99.14 µmol g−1 h−1 with C2H6 selectivity of 80.33% over 20 h in pure water. A record STC efficiency of ≈1.13% for solar fuel production from CO2 and H2O vapor is also achieved without any other energy inputs. Outdoor tests also demonstrated an impressive CO2‐to‐C2H6 photo‐conversion rate of 43.17 µmol g−1 h−1 in pure water, with stable activity over 50 h period. Critically, experimental and theoretical calculations further confirm the pivotal role of bridged C sites and N vacancies in activating CO2 molecules and promoting the formation of C─C coupling intermediate (*OCCO), which is very beneficial for the production of C2H6. The impressive performance of this work in the photocatalytic conversion of CO2 to high‐value C2H6 fuels paves the way for large‐scale fuel production and broader sustainable applications.
A Self‐Detection Mechanism Toward Stable Multiple Perception of Ionic Skins
Authors: Shen Shuting , Liu Chengfei , Fan Wenxin , Sui Kunyan 
Published: February 2025

AbstractIonic skins (I‐skins) hold significant potential for mimicking the complex sensory functions of human skin. However, they suffer from unstable sensing performance because the water content and temperature of I‐skins are susceptible to the surrounding environment. Here, a self‐detection sensing mechanism designed to address this critical issue, ensuring stable perception of multiple stimuli in I‐skins, is introduced. It is demonstrated that gradient polyelectrolyte (GP) conductors possess two parameters—resistance and self‐induced potential—that are responsive to temperature and water content. Through establishing the functional relations of resistance and potential against temperature and water content based on the Nernst−Planck and Arrhenius equations, respectively, the temperature and water content of resulting GP I‐skins can be self‐detected/calculated in real‐time from the measured resistance and potential signals. Such self‐detection capability allows GP I‐skins not only to self‐calibrate their sensing parameters for accurate detection of mechanical stimuli across varying environmental conditions but also to discern surrounding temperature and humidity in accordance with Flory−Rehner theory. This self‐detection sensing mechanism offers a powerful tool for developing I‐skins capable of stable perception of multiple stimuli in changing environments without complex and undesired encapsulation.
Engineering Novel DNA Nanoarchitectures for Targeted Drug Delivery and Aptamer Mediated Apoptosis in Cancer Therapeutics
Authors: Dwivedy Abhisek , Baskaran Dhyanesh , Sharma Gaurav , Hong Wei , Gandavadi Dhanush , Krissanaprasit Abhichart , Han Joonsu , Liu Yusheng , Zimmers Zack , Mafokwane Tshepo , Hayah Ichrak , Chauhan Neha , Zheng Mengxi , Yao Sherwood , Fraser Keith , Decker John S. , Jin Xiaohe , Wang Hua , Friedman Adam D. , Wang Xing 
Published: February 2025

AbstractThe specific and potent delivery of anticancer drugs to targeted cancer stem cells (CSCs) remains a critical need to maximize on‐target, on‐tumor effects while minimizing on‐target, off‐tumor toxicities. Herein, the designer DNA architecture (DDA)‐templated drug conjugates (DDA‐DCs) customized are presented to deliver daunorubicin (Dau) specifically and potently to a subset of CSCs: acute myeloid leukemia (AML) leukemic stem cells (LSCs) that often maintain minimal residual disease (MRD) and cause relapse. These DDA‐DCs target LSCs via CD117‐ and CD123‐binding aptamers: aptamers that when used alone disrupts the MAP Kinase and apoptosis signaling pathways, leading to a 40% reduction in cell viability over 72 h. These aptamers, when loaded with dsDNA‐intercalating Dau and docked to DDA platforms, exhibit potent and selective cytotoxicity against CD117+/CD123+ AML cells, achieving a reduction in effective drug dosage by 500‐fold ex vivo and up to 10‐fold in vivo AML models. These DDA‐DC strategy confers many advantages over other targeted therapies, such as selective cell targeting based on cell surface biomarker profiles (not just individual biomarkers that are often expressed by healthy tissues), titratable affinity, pattern matching, multiplexing, multidrug delivery, and target cell drug sensitization. The combination of these features yields superior anticancer efficacies with minimal off‐target effects.
Continuous‐Wave Pumped Self‐Assembled Colloidal Topological Lasers
Authors: Duan Rui , Zhang Qiang , Thung Yi Tian , Zhou Xuehong , Yin Tingting , Ao Yutian , Xiao Lian , Zhang Zitong , Lee Calvin Xiu Xian , Ren Tianhua , Demir Hilmi Volkan , Lew Wen Siang , Zhang Baile , Sun Handong 
Published: February 2025

AbstractThe field of optoelectronic integrated circuits is actively developing reliable and efficient room‐temperature continuous‐wave (CW) lasers. CW‐pumped lasers combine the economical and simple manufacturing processes of colloidal semiconductor lasers with the efficient and stable output of continuous pumping, enabling them to significantly impact the field of semiconductor lasers. However, development is still severely challenged by limitations such as gain materials and cavity structures. Consequently, as a compromise, most colloidal semiconductor lasers proposed to date have relied on another pulsed laser as the pumping source. In this study, a self‐assembled colloidal topological laser is proposed that benefits from CW pumping at room temperature. By utilizing an interfacial self‐assembly strategy, nanoplatelets (NPLs) are managed to control the collective orientation (face‐down or edge‐up), achieving controlled polarization of amplified spontaneous emission for the first time. Furthermore, precise control over the thickness of a single NPL layer is demonstrated, which enables the laser system to offer extensive wavelength tunability (over 50 nm), ultra‐high polarization (over 95%), and good temporal stability. These metrics signify the optimal performance level of colloidal semiconductor lasers, marking a new era in solution processing systems for the optoelectronic integrated circuit field.
Interpretable Radiomics Model Predicts Nanomedicine Tumor Accumulation Using Routine Medical Imaging
Authors: Tang Jiajia , Zhang Jie , Li Yang , Hu Yongzhi , He Doudou , Ni Hao , Zhang Jiulou , Wu Feiyun , Tang Yuxia , Wang Shouju 
Published: February 2025

AbstractAccurately predicting nanomedicine accumulation is critical for guiding patient stratification and optimizing treatment strategies in the context of precision medicine. However, non‐invasive prediction of nanomedicine accumulation remains challenging, primarily due to the complexity of identifying relevant imaging features that predict accumulation. Here, a novel non‐invasive method is proposed that utilizes standard‐of‐care medical imaging modalities, including computed tomography and ultrasound, combined with a radiomics‐based model to predict nanomedicine accumulation in tumor. The model is validated using a test dataset consisting of seven tumor xenografts in mice and three sizes of gold nanoparticles, achieving an area under the receiver operating characteristic curve of 0.851. The median accumulation levels of tumors predicted as “high accumulators” are 2.69 times greater than those predicted as “low accumulators”. Analysis of this machine‐learning‐driven interpretable radiomics model revealed imaging features that are strongly correlated with dense stroma, a recognized biological barrier to effective nanomedicine delivery. Radiomics‐based prediction of tumor accumulation holds promise for stratifying patient and enabling precise tailoring of nanomedicine treatment strategies.
Ultra‐Sensitive Short‐Wave Infrared Single‐Photon Detection Using a Silicon Single‐Electron Transistor
Authors: Sudha Pooja , Miyagawa Shogo , Samanta Arup , Moraru Daniel 
Published: February 2025

AbstractUltra‐sensitive short‐wave infrared (SWIR) photon detection is a crucial aspect of ongoing research in quantum technology. However, developing such detectors on a CMOS‐compatible silicon technological platform has been challenging due to the low absorption coefficient for silicon in the SWIR range. In this study, a codoped silicon‐based single‐electron transistor (SET) in a silicon‐on‐insulator field‐effect transistor (SOI‐FET) configuration is fabricated, which successfully detects single photons in the SWIR range with ultra‐high sensitivity. The detection mechanism is evidenced by the shift in the onset of the SET current peaks and by the occurrence of random telegraph signals (RTS) under light irradiation, as compared to the dark condition. The calculated sensitivity of our device, in terms of noise equivalent power (NEP), is ≈10−19 W Hz−1/2.
Realization of Non‐Equilibrium Wurtzite Structure in Heterovalent Ternary MgSiN2 Film Grown by Reactive Sputtering
Authors: Kageyama Sotaro , Okamoto Kazuki , Yasuoka Shinnosuke , Ide Keisuke , Hanzawa Kota , Hiranaga Yoshiomi , Hsieh Pochun , Hazra Sankalpa , Suceava Albert , Saha Akash , Yokota Hiroko , Shigematsu Kei , Azuma Masaki , Gopalan Venkatraman , Uchida Hiroshi , Hiramatsu Hidenori , Funakubo Hiroshi 
Published: February 2025

AbstractThe piezoelectric and ferroelectric applications of heterovalent ternary materials are not well explored. Epitaxial MgSiN2 films are grown at 600 °C on (111)Pt//(001)Al2O3 substrates by the reactive sputtering method using metallic Mg and Si under the N2 atmosphere. Detailed X‐ray diffraction measurements and transmission electron microscopy observations revealed that the epitaxially grown films on the substrates have a hexagonal wurtzite structure with c‐axis out‐of‐plane orientation. The random occupation of this structure by Mg and Si differs from that of the previously reported structure in which these two cations periodically occupy the cationic sites. However, the lattice spacings closely approximate those that are previously reported, irrespective of the ordering, and they are almost comparable with those of (Al0.8Sc0.2)N. The wide bandgap of >5.0 eV in deposited MgSiN2 is compatible with that of AlN and suggests durability against the application of strong external electric fields, possibly to induce polarization switching. In addition, MgSiN2 is shown to have piezoelectric properties with an effective d33 value of 2.3 pm V−1 for the first time. This work demonstrates the compositional expansion of hexagonal wurtzite to heterovalent ternary nitrides for novel piezoelectric materials, whose ferroelectricity is expected.
Outcomes of Relapsed or Refractory Diffuse Large B‐Cell Lymphoma Treated With R‐GemOx: A Multicenter Cohort Study
Authors: Yamshon Samuel , Koff Jean L. , Larson Melissa C. , Kahl Brad S. , Casulo Carla , Lossos Izidore S. , Haddadi Sara , Stanchina Michele , Chihara Dai , Ayers Amy , Habermann Thomas M. , Wang Yucai , Khurana Arushi , Nowakowski Grzegorz S. , Reicks Tanner W. , Farooq Umar , Link Brian K. , Cohen Jonathon B. , Martin Peter , Li Jia , Shewade Ashwini , Batlevi Connie Lee , Lo‐Rossi Andrea , Fox David , Masaquel Anthony , Mun Yong , Cerhan James R. , Flowers Christopher R. , Maurer Matthew J. , Nastoupil Loretta J. 
Published: February 2025

ABSTRACTRituximab, gemcitabine, and oxaliplatin (R‐GemOx) is a commonly used chemoimmunotherapy regimen for relapsed or refractory (R/R) diffuse large B‐cell lymphoma (DLBCL), but there are limited real‐world data. In a multicenter retrospective study from a cohort of eight US academic centers (LEO CReWE), we evaluated 183 patients with R/R DLBCL and high‐grade B cell lymphoma treated with R‐GemOx, including subgroups treated without intent for consolidation with autologous stem cell transplant (ASCT) or chimeric antigen receptor (CAR) T cell therapy (n = 100), those utilizing R‐GemOx as a bridge to ASCT or CAR T (n = 83), and those aged 70 and older (n = 71). Overall response rates (ORRs) for all patients treated with R‐GemOx were 45% with a complete response (CR) rate of 29%. The median event‐free survival (EFS) was 2.3 months, and the median overall survival (OS) was 13.5 months. Patients receiving R‐GemOx without intent for ASCT or CAR T had ORR and CR rates of 33% and 18%, respectively, with median EFS and OS of 2.0 and 9.5 months, respectively. Patients receiving R‐GemOx as a bridge to ASCT or CAR T had ORR and CR rates of 57% and 36%, respectively, with median EFS and OS of 3.5 and 17.4 months, respectively. Patients receiving R‐GemOx aged 70 and older had ORR and CR rates of 53% and 33%, respectively, with median EFS and OS of 2.2 and 13.9 months, respectively. These data provide a benchmark for R‐GemOx in the rapidly evolving landscape of R/R DLBCL therapies.
Establishment and characterization of liver‐specific Apoa4‐Cre and Cyp2c11‐Cre rat models in juvenile and adult stages
Authors: Dong Wei , Gao Xiang , Guan Feifei , Pan Jirong , Chen Wei , Zhang Li , Zhang Lianfeng 
Published: February 2025

AbstractBackgroundLiver diseases are a major contributor to both morbidity and mortality. Conditional knockout animals are always produced through crossing floxed animals with a tissue‐specific Cre animal. The use of floxed rat resource has rapidly increased, but the liver‐specific Cre rat lines for studying liver diseases and interested genes are limited, especially in a spatially and temporally restricted manner.MethodsRNA sequencing and real‐time polymerase chain reaction (PCR) were used to screen and confirm the presence of liver‐specific genes. Apoa4‐Cre rats and Cyp2c11‐Cre rats were produced by CRISPR/Cas9 knockin. Rosa26‐imCherry rats were employed to hybridize with the Cre rats to obtain the Apoa4‐Cre/Rosa26‐imCherry and Cyp2c11‐Cre/Rosa26‐imCherry rats. The temporal and spatial patterns of Cre expression were determined by the observation of red fluorescence on tissue sections. Hematoxylin–eosin stain was used to evaluate the liver histopathologic changes. The blood biochemical analysis of several liver enzymes and liver lipid profile was performed to evaluate the liver function of Cre rats.ResultsApoa4 and Cyp2c11 were identified as two liver‐specific genes. Apoa4‐Cre and Cyp2c11‐Cre rats were produced and hybridized with Rosa26‐imCherry rats. The red fluorescence indicated that the Cre recombinases were specially expressed in the juvenile and adult liver and not in other organs of two hybridized rats. All the blood biochemical parameters except low‐density lipoprotein (LDL) did not change significantly in the Cre rats. No histological alterations were detected in the livers of the Cre rats.ConclusionsLiver‐specific Apoa4‐Cre and Cyp2c11‐Cre rats have been established successfully and could be used to study gene knockout, specifically in juvenile and adult liver.
Barrierless Electron Transfer in a Photosynthetic Reaction Center Model
Authors: Ullrich Tobias , Ramírez‐Wierzbicki Ivana , Slep Leonardo D. , Cadranel Alejandro 
Published: February 2025

AbstractVibrational spectroscopy is the ultimate tool to reveal whether any donor‐acceptor system is truly delocalized and therefore characterized by a single‐welled potential energy surface, or if it is marginally localized with a barrier that defines two minima. Our femtosecond IR absorption investigations on cyanide‐bridged mixed valence systems show a broad, intense and downshifted CN vibration signature, revealing, for the first time, an asymmetric, fully delocalized Class III photoinduced mixed valence system.
Permeability of 3D Printed Acrylate Rubbers
Authors: Stovall Benjamin J. , Rafalko Charles J. , Cassady Harrison J. , Zimudzi Tawanda J. , Nyoni Hlengilizwe , Hickner Michael A. 
Published: February 2025

ABSTRACTThe versatility of vat photopolymerization additive manufactured (VPAM) elastomers garners much interest in the production of medical supplies and microfluidic devices. However, little research has characterized the liquid barrier properties and chemical resistance specifically related to these emerging acrylate‐based VPAM polymers. Herein, we describe a systematic approach to studying the structure–property relationships for a series of 3D printable elastomers from commonly used monomers and crosslinkers, including n‐butyl acrylate (BA) and 2‐hydroxyethyl acrylate (HEA). Polymer samples showed elongations‐to‐break between 200%–400% and Young's moduli between 0.4–0.6 MPa. The study helps to develop a picture of the chemical space inhabited by these model systems via permeability experiments and relation to Hansen solubility parameters (HSPs). The permeability of the tested solvents dimethyl sulfoxide (DMSO), dimethylformamide (DMF), pyridine, isopropanol (IPA), and tetrahydrofuran (THF) was related to the composition and increased water uptake of the materials. As the weight percent of HEA increased in the polymer composition, the permeability of all solvents increased. The magnitude of the permeability depended on solvent interactions with water, quantified by HSPs, and was independent of polymer composition. THF exhibited the highest permeability through the polymer membranes due to its low HSP. The formulated elastomers represent modular VPAM materials accessible with current commercial 3D printing technology that can be deployed for specific applications.
A Transparent, Abrasion‐Resistant Anti‐Fog Coating on Glass Substrates
Authors: Yang Sijia , Song Xiao , Wei Ran , Zhou Chuanjiang , Wu Zhaoqiang , Chen Hong 
Published: February 2025

ABSTRACTThe formation of fog on the surface of transparent glass severely reduces its transmittance, which limits its application in medical devices, optical instruments, and other industries that require high transmittance. A new transparent, water‐resistant, and abrasion‐resistant PVA anti‐fog coating based on polyvinyl alcohol (PVA), 5‐sulfosalicylic acid (SAD), and ammonium persulfate (APS) was developed in this study. The hydroxyl, carboxyl, and sulfonic acid groups in the SAD molecule can form dense hydrogen bonds with the hydroxyl groups on the PVA side chain, which increases the water resistance of the coating. APS, as a free radical initiator, can produce sulfate radicals during the thermal curing of the coating and eventually form a cross‐linked structure of the PVA main carbon chain, thereby further improving the water resistance, friction resistance, and thermal stability of the coating. The experimental results show that the transparent glass surface modified by the coating not only has excellent light transmittance and anti‐fog performance but also has good abrasion resistance and thermal stability. In addition, the preparation method of the transparent hydrophilic anti‐fog coating is simple and convenient, and nontoxic and environmentally friendly water is used as the solvent, which is expected to be used in large‐scale industrial production.
Self‐Healing Waterborne Polyurethane With Enhanced Mechanical Properties Based on Nano‐Silica
Authors: Zhao Kaiyang , Zhou Chao , Liu Li , Wu Guangfeng 
Published: February 2025

ABSTRACTWaterborne polyurethanes with self‐healing damage and restore mechanical properties became widely used. The self‐healing performance was closely related to good chain segment mobility, but loose chain segments could weaken mechanical properties. High mechanical performance and high self‐healing performance were contradictory. Therefore, research on how to ensure high self‐healing while improving the mechanical properties of materials became one of the research directions for self‐healing materials. In this work, waterborne polyurethanes with disulfide bonds were first prepared, and then nano‐silica was dispersed through mechanical stirring to obtain silica‐modified self‐healing waterborne polyurethane (SWPU‐SiX). The effect of nano‐silica content on the properties of SWPU‐SiX were studied. It was found that the tensile strength of the prepared material reached 16.58 MPa, and the toughness reached 67.51 MJ/m3representing increases of 397.57% and 150.43% compared to SWPU, respectively. It could be almost completely healed at 80C. The enhancement of these properties provides a new method for the research of self‐healing materials.