bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic utility of biopsy-based PTEN and ERG status on biochemical progression and overall survival after SBRT for localized prostate cancer
Authors: Repka Michael C. , Sholklapper Tamir , Zwart Alan L. , Danner Malika , Ayoob Marilyn , Yung Thomas , Lei Siyuan , Collins Brian T. , Kumar Deepak , Suy Simeng , Hankins Ryan A. , Kishan Amar U. , Collins Sean P. 
Published: March 2024

Introduction/backgroundPhosphatase and tensin homolog (PTEN) genomic deletions and transmembrane protease, serine 2/v-ets avian erthyroblastosis virus E26 oncogene homolog (ERG) rearrangements are two of the most common genetic abnormalities associated with prostate cancer. Prior studies have demonstrated these alterations portend worse clinical outcomes. Our objective is to evaluate the impact of biopsy-determined PTEN losses and TMPRSS2-ERG fusion on biochemical progression-free survival (bPFS) and overall survival (OS) in patients who receive SBRT for localized prostate cancer.Methods/materialsPatients received SBRT for localized prostate cancer on a prospective quality-of-life (QoL) and cancer outcomes study. For each patient, the single biopsy core with the highest grade/volume of cancer was evaluated for PTEN and ERG abnormalities. Differences in baseline patient and disease characteristics between groups were analyzed using ANOVA for age and χ2 for categorical groupings. bPFS and OS were calculated using the Kaplan Meier (KM) method with Log-Rank test comparison between groups. Predictors of bPFS and OS were identified using the Cox proportional hazards method. For all analyses, p &lt;0.05 was considered statistically significant.ResultsNinety-nine consecutive patients were included in the analysis with a median follow-up of 72 months. A statistically significant improvement in bPFS (p = 0.018) was observed for wild type ERG patients with an estimated 5-year bPFS of 94.1% vs. 72.4%. Regarding PTEN mutational status, significant improvements in were observed in both bPFS (p = 0.006) and OS (p &lt; 0.001), with estimated 5-year bPFS rates of 91.0% vs. 67.9% and 5-year OS rates of 96.4% vs. 79.4%. When including both ERG and PTEN mutational status in the analysis, there were statistically significant differences in both bPFS (p = 0.011) and OS (p &lt; 0.001). The estimated 5-year bPFS rates were 100%, 76.6%, 72.9%, and 63.8% for patients with ERG+/PTEN+, ERG-/PTEN+, ERG+/PTEN-, and ERG-/PTEN- phenotypes respectively. The estimated 5-year OS rates were 93.9%, 100%, 80.0%, and 78.7% for patients with ERG+/PTEN+, ERG-/PTEN+, ERG+/PTEN-, and ERG-/PTEN- phenotypes respectively.ConclusionERG rearrangements and PTEN deletions detected on biopsy samples are associated with poorer oncologic outcomes in prostate cancer patients treated with SBRT and merit further study in a dedicated prospective trial.
Early Childhood in Marginalized Roma Communities: Health Risks and Health Outcomes
Authors: Filakovska Bobakova Daniela , Dankulincova Veselska Zuzana 
Published: March 2024

Objectives:This study aims to compare selected early childhood health risks and health outcomes of children from marginalized Roma communities (MRCs) in Slovakia with those of the majority.Methods:We obtained cross-sectional data from mother-child dyads from the majority (N = 109) and MRCs (N = 143) via questionnaires and from medical records. Socioeconomic status, health risks and health outcomes were compared using chi-square and Mann-Whitney U tests in SPSS.Results:Mothers from MRCs reported significantly worse socioeconomic status. Air quality in the households in MRCs was significantly worse, affected by heating with stoves, burning fresh wood and indoor smoking. The diet composition of children from MRCs was characterized by shorter breastfeeding and unhealthy diet composition less fresh fruits and vegetables, more processed meat products, and sweet and salty snacks. Children from MRCs more often suffered from respiratory and diarrheal diseases, used antibiotics and were hospitalized.Conclusion:The health and healthy development of children living in MRCs is endangered by various poverty-related factors. Persistent differences in exposures and health in early childhood should be a priority goal of the state’s social and health policies.
PRACTICAL CLASSES AS A FORM OF COMPETITIVE PHARMACY SPECIALIST TRAINING
Authors: Sholoyko N. 
Published: March 2024

In the article, in line with the tasks of forming the organizational and managerial culture of masters of pharmacy based on the concept of the development of the pharmaceutical industry as an integral component of the country’s health care system, the goal is realized. It is to clarify the role of practical classes as the leading organizational form of the educational process of training highly qualified personnel who develop and implements a modern system of ensuring the quality of medicinal products, has not only fundamental knowledge of physics, chemistry, biology, scientific management, special disciplines, but also has an extensive system of practical skills and professional activity skills.
On the basis of the general pedagogical principle of the unity of theory and practice, practical training is characterized as the leading organizational form of the educational process of professional training of pharmacy managers, which has its own objectives, intended for the development of students’ professional and practical skills necessary for specialists to perform their duties relationships and formation of professional and business qualities of graduates of the master’s level of education.
The works of Ukrainian scientists in terms of types, structure, methods of conducting, specifics of training teachers and students for practical classes of various forms and types are adapted to the needs of a specific field of specialist training.
It was concluded that the intensification of the educational process stimulates the use of advanced learning technologies accumulated by practice by teachers in practical classes. Practical classes are conducted using the elements of discussion, business game, "brainstorming", dyadic form of work of applicants (performance of tasks to consolidate the material in pairs, control of knowledge, evaluation of completed actions and tasks), etc. The summary of the results of a practical session with future pharmacists is often in the form of a colloquium, where the candidates announce their written results and briefly explain them. You can participate in the discussion of the proposed decision by expressing your opinion, motivating and arguing it.
DEVELOPMENT OF PROFESSIONAL CULTURE OF COLLEGE STUDENTS CULTURE AND ARTS WHEN STUDYING DISCIPLINES DECORATIVE AND APPLIED ARTS
Authors: Tetianin I. , Cherniavska O. 
Published: March 2024

Analysis of culture as an anthropological phenomenon shows that culture is congruent with human beings. Historically, the cultural phenomenon has always reflected processes related to education, enlightenment, formation, and development of a person. Without education and training, without the active transmission of new achievements of human culture to new generations, the movement of history would be impossible. Therefore, the article updates the expediency of using profile subjects from the specialty «Decorative and Applied Arts» as a component of attracting first-year students of art educational institutions to the formation of their own professional culture.
The main art subjects and tasks (from simple to complex) are introduced into the educational context of future artist-decorative and applied arts teacher training are considered. Students are involved in working on the material together with the teacher. The student learns all the subtleties of mastery in practical work. In the mentioned direction, the concepts of «competence» and «mastery» are distinguished. It is stated that professional skill involves comprehensive knowledge of production or any other professional process, the ability to implement it, to set it in motion.
Since the development of culture and education are processes that are carried out mainly in parallel, synchronously, and interconnected, the essence of the meaning of the technology of situational learning (case method), which consists in modeling a specific situation that occurs in regional professional practice, has been clarified. Based on that, a didactic package of tasks for solving a certain issue is developed. The case method for first-year students is specific learning situations that are specially developed based on actual material for further study in classes.
ACTUAL ASPECTS OF MODERNIZATION OF PROFESSIONAL EDUCATION OF MILITARY PERSONNEL OF THE DEFENSE FORCES IN THE PERIOD OF MARTIAL LAW
Authors: Bukhun A. 
Published: March 2024

The study updates the aspects of modernization of military education in Ukraine, which is determined by the military and political situation in the country, the need to increase the efficiency of the defense forces and the Armed Forces, reforming the national legislative framework for the professional training of military personnel in the context of joining the standards of the North Atlantic Treaty Organization (NATO).
The purpose of the article is to find out the social need for joint professional training of military personnel of the defense forces (the Armed Forces, law enforcement units, units of the State Border Service, the National Guard, the Security Service of Ukraine, etc.) and the possibilities of implementing its objectives by means of building integration models and technologies of the educational process.
The research has been conducted using the following theoretical methods: systematic analysis, comparison, induction and deduction, and usage of the methodological and theoretical tools of the competence-based scientific approach.
The following conclusions have been made: taking into account the integration processes of the field of military education in Ukraine, related to the liberation war and the country’s entry into the international security environment, the tasks caused by the modernization of the military education system are crucial. They must take into account the experience of a modern full-scale war, when the Armed Forces of Ukraine, the National the Guard of Ukraine and the State Border Service perform joint defense functions. It means that they need specialists who directly participate in defense and stabilization operations and have the appropriate professional competence.
At the same time, the lack of a united content system of professional military education and training, which contributes to the establishment of cooperation between the components of the defense forces within the framework of the implementation of tasks to ensure the defense of the state, is a particular problem. It has a negative impact on the interaction of the defense forces in the process of fulfilling the tasks provided for by the legislation. Therefore, the development of models of continuous education of military personnel for implementation by all law enforcement agencies in order to improve the quality of training of the social group of military professionals vital for the country is determined to be promising.
Perkawinan Beda Agama Pasca Keluarnya Surat Edaran Mahkamah Agung (SEMA) Nomor 2 Tahun 2023 Ditinjau dari Perspektif Maqashid Syariah
Authors: Khairina Safira Nafa , Hidayati Tri Wahyu 
Published: March 2024

Konsep Maqashid Syariah untuk mewujudkan kemaslahatan harus tetap diperjuangkan dan diaplikasikan hingga saat ini, Meskipun teks Al-Quran telah berhenti namun permasalahan yang kita hadapi akan terus berkembang, maka Maqashid Syariah datang sebagai pintu untuk menyelesaikan masalah hukum-hukum Islam, Fenomena Perkawinan beda agama masih menjadi isu yang kontroversial dikarenakan terkabulnya permohonan perkawinan beda agama di Pengadilan Negeri Jakarta Pusat dalam putusan perkara nomor 155/Pdt.P/2023/PN.Jkt.Pst. Dengan demikian maka Mahkamah Agung mengeluarkan SEMA Nomor 2 Tahun 2023 yang ditujukan kepada Ketua/Kepala Pengadilan Tinggi Banding dan Ketua/Kepala Pengadilan Tingkat Pertama. Jenis penelitian ini merupakan penelitian kualitatif dengan pendekatan yuridis normatif yaitu menggali data dari aspek kepustakaan. Dengan dikeluarkanya SEMA No. 2 Tahun 2023 diharapkan dapat menjawab atas ketidakpastian hukum yang selama ini diresahkan masyarakat serta menjadi akhir dari polemik perkawinan beda agama dan diharapkan semua Hakim tunduk pada SEMA tersebut. Agar prinsip-prinsip maqashid syariah tetap terjaga.
Strategi Prinsip Ekonomi Islam dalam Meningkatkan Ketahanan Ekonomi Keluarga Muslim Di Kabupaten Demak
Authors: Lia Sari Risti 
Published: March 2024

This research aims to find out the principles of Islamic Economics in increasing the economic resilience of Muslim families in Demak Regensy and to find out what strategies the principles of Islamic Economics have in creasing the economic resilience of Muslim in Demak Regency. The Urgency or priority of this research was carried out in the hope that the Islamic Economic Principles strategy could help in increasing the economic resilience of Muslim families in Demak Regency. Tools / Intruments This research is a type of field research with qualitative research methods. The result of thisresearch are the principles of Islamic Economics in increasing the economic resilience of Muslim families in Demak Regency, including by balancing sources of incoming and asset ownership, estabilishing cooperation or syirkah, equitable social security, the role of government
Keywords : Islamic Economic, Principles, family economic security
Faktor-Faktor Yang Mempengaruhi Konsumen Dalam Mengambil Keputusan Jual Beli Emas Di Kalinyamatan Jepara Dalam Perspektif Islam
Authors: ANWARUSSAID  , Susilo Edi , Aminnudin Moch 
Published: March 2024

Masyarakat Kalinyamatan Jepara dominan beragama islam. Sebagai seorang muslim, hendaknya dalam melakukan kegiatan transaksi jual beli perlu dilandasi perilaku yang baik sesuai dengan ajaran Islam. Penelitian ini bertujuan untuk menguji adanya faktor faktor yang mempengaruhi konsumen dalam pengambilan keputusan jual beli emas di Kalinyamatan Jepara. Penelitian ini merupakan penelitian kuantitatif deskkriptif. Populasi dalam penelitian ini adalah masyarakat Kalinyamatan Jepara yang melakukan transaksi jual beli emas dan sampel yang diambil sebanyak 100 responden dengan menggunakan teknik simple random sampling. Metode pengumpulan data melalui penyebaran kuesioner. Teknik analisis data menggunakan regresi berganda dengan bantuan analisis menggunakan program SPSS versi 25.
Variabel independen dalam penelitian ini adalah perilaku konsumen (X1), jual beli (X2), dan faktor pengambilan keputusan (X3) variabel dependen pengambilan keputusan (Y). Hasil dari penelitian ini dapat disimpulkan bahwa secara parsial hanya perilaku konsumen yang berpengaruh signifikan terhadap perilaku pedagang dengannilai thitung sebesar 1,966 dan nilai probabilitas signifikansi 0.050, sedangkan jual beli dan faktor prngambilan keputusan tidak berpengaruh signifikan terhadap pengambilan keputusan. Kemudian berdasarkan Uji F perilaku konsumen, jual beli, faktor pengambilan keputusan secara simultan (bersama-sama) berpengaruh signifikan terahadap variabel pengambilan keputusan.
L’espace analytique des groupes thérapeutiques
Authors: Lucas Pierre 
Published: March 2024

El espacio analitico en los grupos terapeuticos.
El lugar del analista esta en estrecha relacion con la especificidad de los grupos. Particularmente, este no puede ser percibido y comprendido sino es en relacion con todo lo que constituye el encuadre.
El proyecto aqui es relativamente limitado : saber si el concepto de “espacio analitico” elaborado por S. Viderman como fundamental para la cura puede aclararnos sobre el trabajo del grupo como trabajo psicoanalitico. Este concepto aparece como vinculado al espacio psiquico e igualmente a los dispositivos y modos de funcionamiento, es decir al encuadre.
En cuanto al grupo, el proyecto terapeutico y la preocupacion psicoanalitico nos ha conducido a releer la introduccion de “Psicologia de las masas y analisis del yo” desde un angulo particular. El encuadre del grupo del cual hablamos aquí, nos apareció como un punto culminante del cuar la mirada podia ir, ya hacia todos los fenomenos que nos la muestran como una pequeña maso, ya hacia lo que parece constituir un circulo limitado de la primeras relaciones, tales como las que coda uno esta acostumbrado a encontrar.
Le destin de représentations buts
Authors: Levental Jean-Yves 
Published: March 2024

La possibilité de représentation sur la scène de psychodrame implique le niveau de convergence des préoccupations de chaque individu et la «poussée» respective des membres pour amener et interroger ces préoccupations dans le groupe. Plusieurs étapes se dessinent :
— chaque individu se soumet à un travail de promotion de représentation dans son intra-psychisme ;
— il conduit ses représentations dans le groupe, il s’en fait le «représentant » ;
— le groupe réagit selon divers degrés de tolérance vis-à-vis de la ou des personnes représentantes et des idées qu’elles apportent.
Pour aborder ces dimensions, j’ai choisi certaines moments de psychodrame dans des groupes qui comptent des patients psychotiques. C’est dans le sens où je pose l’effectivité de la représentation dans ses relais de l'intra-individuel à l'intra-groupal que je m’autorise à peindre ces moments groupaux comme autant de dispositions d’une entité psychique.
Les archétypes de la famille et les espaces de l’inconscient
Authors: Miermont Jacques 
Published: March 2024

Los arquetipos de la familia y los espacios del inconsciente.
Las relaciones entre procesos conscientes e inconscientes seron debatidas a la luz de los desarrollos teoricos y pragmaticos contemporaneos :
En el regis tro teorico, despues de los modelos ciberbeticos, respuestas nuevas han sido aportadas por las investigaciones sobre la auto-referencia (G. Spencer-Brown, F. Varela), y por los modelos topologicos y catastroficos (E. C. Zeeman, R. Thom, J. Petitot).
En el registro de cierto control experimental en ciencias humanas, los diferentes abordajes de la terapia familiar demuestran los efectos de la pragmatica de las communicaciones sobre las estructuraciones psiquicas, y la importancia de las implicaciones e imbricaciones multipersonales, individuates y colectivas, tanto materiales como ficticias en dichas estructuraciones.
A la luz de las teorias de R. Thom sobre la morphogenese, proponemos una tentativa de considerar la existencia de formas familiares arqui-grupales, inconscientes qui estabilizan para el nino y mas tarde para el adulto el sentido de las palabras, de los afectos, de las esperiencias. Inversamente dificultades de estructuracion de las morfologias familiares pueden desestabilisar las adquisiciones semanticas.
Fantasmes précoces dans un groupe d’enfants
Authors: Resnik Salomon 
Published: March 2024

Fantasmas precoces en un grupo de niños.
En este trabajo queria discutir algunos aspetos de la dinámica grupal en un grupo de niños.
La aceleración y los cambios de ritmo, así como la acentuación del fenómeno de regresión en el grupo, forman parte de un languaje et de una samántica complejas. El problema de identidad del individuo en el grupo y del grupo mismo de una parte y las visicitudes de la transferencia (doble transfer encia) por otra, prestan une multiplicidas de significados que dada la diversidad de la experiencia misma requiere prudencia y rigor a la vez.
Para ilustrar mi punto de vista he elegido este grupo de ninos a causa de la riqueza y plasticidad, que a través del juego o de la dificultad de jugar, dado su grado de violencia pulsional, permite por otra parte comprender y confirmar cierto tipo de ansiedades precoces, tal como Mélanie Klein las ha descrito y formulado. Trato también de transmitir las alternativas espaciales que se «juegan» en la transferencia y sus diversos significados : la proyección de limites o la necesidad de fronteras del cuerpo grupal ; la necesidad de contención de las pulsiones destructivas y el modo como el terapeuta mismo vive «el campo de juego», donde a su vez proyectará su propio sistema referencial e ideológico (espacio-temporal). Para poder investigar «vividamente» sus propias intenciones y teorias. Toda interpretación es «une teoria» de lo que ocurre, une hipóteis sobre fenómenos taies corne envidia y celos, pero también partes de un proceso conservativo «en juego» que permitira elaborar adecuadamente la ansiedad grupal et propender al desarollo de la capacidad integrative del Yo grupal e individual.
Relaxation psychothérapique individuelle ou groupale dans le traitement des troubles digestifs fonctionnels
Authors: Peter Daniel 
Published: March 2024

Individual or group psychotherapeutic relaxation for the treatment of functional digestive disorders.
Psychotherapic relaxation is now a method of choice in addressing functionnal disorders that often puzzled both physicians and psychiatrists. The choice of this technique over conventional ones is largely dictated by the actual interaction patient/ therapist rather that by finding a specific psychiatric pathology. Several clinical cases of patients, suffering digestive fonctional disorders and treated by psychotherapic relaxation, are shown to highlight the relationships between somatization and consciousness, external and internal conflicts.
De la représentation du mythe à la reconstruction de l’histoire
Authors: Gaudriault Martine , Héry Philippe , Levental Jean-Yves , Prochasson Jean , Cunha Roberto 
Published: March 2024

De la representación del mito a la reconstrucción de la historia.
El psicodrama de grupo permite el paso de una narración a-histórica, mitica (el «representar Diós» de Moreno) hacia la emergencia de un sujeto anclado en su dimensión corporal, en su historicidad y en su confrontación à la alteridad. Eso se vuelve posible gracias al hecho de «hacer como si» que va inscribir un acto de palabra en un tiempo, en un espacioyen una interlocución Yo-Tu. Pero el psicodrama no podrá lograr plenamente sus metas si el juego entre yo y el otro, presentado en la escena grupal, no es escuchado y retomado en todas sus dimensiones in tertransferenciales.
Pourquoi le groupe ?
Authors: Gilliéron Edmond 
Published: March 2024

Porqué el grupo ?
Discusión del proceso que conduce a la indicación de una psicoterapia de grupo. Existe allí un sistema de interacción dinámico en el que las necesidades de apoyo objetal del sujeto estan en juego. Las primeras interpretaciones deben permitir una toma de conciencia del carácter intrasubjetivo de los conflictos que conducen el paciente a la consulta.
Indications pour la psychothérapie de groupe
Authors: Brown Dennis 
Published: March 2024

Indicaciones para la psicoterapia de grupo.
Se discute sobre las indicaciones de Psicoterapia Analítica de Grupo, tomando en cuenta el contexto clínico del asesor ; las investigaciones recientes ; las formas altemativas de terapia ; la evaluación clínica del paciente ; sus problemas y su potencial y, finalmente, la red terapéutica y la variedad de grupos disponibles y los terapeutas adecuados para coda paciente asesorado. Se describen un encuadre y un método : el del Grup Analytic Practice de Londres.
Hospitalisation du psychodrame
Authors: Gaudriault Martine 
Published: March 2024

Hospitalisation of psychodrama.
Our practice is concerned with a psychiatric hospitalization center in which a groupanafytic psychodrama takes place. Considering our very institution, we make some theoretic focals of a so called psychodrama/hospital working alliance. Why a group psychodrama indication ? What sorts of pathologies may be abble to take part ? What are the benefits we anticipate in using dramatization and groupal patterns ? What is the setting we improved ? What impediments could be met with ?