bluuebunny/crossref_metadata_2025_split huggingface dataset:
A ten year statistical follow‐up of 1142 consecutive cases of cholesteatoma: The closedvs. The open technique
Authors: Brown James S. 
Published: October 2006

AbstractCholesteatoma has long been a formidable adversary to the otologic surgeon. The surgical treatment has been basically by two methods, open and closed. It was felt that a study should be undertaken to compare the results obtained over a long period of time, utilizing these two methods. A need for this study existed as the same number of new cases of cholestentoma was presenting each year.In reviewing the literature, it is found that new advancements have not yet been made in the prevention of the disease and the medical and surgical management has remained essentially the same.The ideal goal of successful surgery, namely an ear without disease, with normal hearing, and an intact drum and posterior canal wall, has been difficult to achieve in a high percentage of cases. To achieve this goal, two main surgical methods have evolved: the classical “open method,” and the more recent “closed method.”In the open method cases, the hearing results were often poor and the cavity presented a management problem. In the closed method there has been a fairly high occurrence of residual, and/or recurrent cholesteatoma which necessitated a second procedure. These two methods were compared by reviewing a large number of histologically proved cholesteatoma cases 10 years after surgery, to determine the incidence of recurrence of cholesteatoma and the residual hearing function.The results of this study show conclusively that the hearing was better using the closed method, but the recurrence rate was considerably higher.This paper presents a practical method of approach to the management of all presenting cases of cholesteatoma.
Co2 laser myringotomy
Authors: Goode Richard L. 
Published: October 2006

AbstractCO2 laser myringotomies were performed in 4 temporal bone specimens, 10 cat ears, and 11 patient ears. The method in cats produced a hole that remained open 3 to 6 weeks and healed without excessive scarring. In the patient ears, 9 of 11 laser myringotomies (82%) healed within 6 weeks. One myringotomy 4 mm in diameter did not heal and one 2 mm myringotomy made through a monomeric membrane did not heal.
Rhabdomyosarcoma of the head and neck
Authors: Feldman Bruce A. 
Published: October 2006

AbstractRhnbdomyosarcoma is an uncommon neoplasm that is seen in the head and neck area. Since the symptoms of rhabdomyosarcoma, such as aural discharge and nasal obstruction Mimic common disease states, the clinical diagnosis is often delayed. Case reports and a literature review are presented to emphasize the clinical and roentgenological findings in rhabdomyosarcoma.Misinterpretation of microscopic findings can delay the histological diagnosis. Cross‐striations, the “hallmark” of rhabdomyosarcoma, are not always found, while “racquet” and “spindle” cells may be seen. Special stains and electron microscopy can assist the pathologist. The pathological findings of the different variants of rhabdomyosarcoma and a review of cases accessioned by the A.F.I.P. Otolaryngic Registry are presented.Early diagnosis of rhabdomyosarcoma is important because the disease, once inevitably fatal, can now be controlled and apparently cured in most cases by a combination of surgery, radiation, and multidrug chemotherapy. This therapeutic approach, its results, complications, and support measures are considered.
Comparison of photosensitizers in saline and liposomes for tumor photodynamic therapyand skin phototoxicity
Authors: Davos R. Kim , Kereszti Zsolt , Straght Richard 
Published: October 2006

AbstractThe uptake and distribution, skin phototoxicity, and direct tumor ablative potential of three porphyrin photosensitizers: hematoporphyrin derivative (HPD), dye hemato‐porphyrin ether (DHE), polyhematoporphyrin esters (PHE), and of Rhodamine‐123 (Rh‐123) have been studied in the AJ‐CR inbred albino female mouse implanted with C‐1300 neu‐roblastoma. Photosensitizer delivery was studied using saline and liposome carriers.The ratio of tumor uptake of the porphyrin compounds compared to the tumor‐bed musculature and skin was favorable with both saline and liposome delivery. Rhodamine‐123 precipitated in saline but was delivered effectively throughout the body in liposomes. There was no selective uptake by tumor cells of Rh‐123 in this tumor model.Skin phototoxicity with the porphyrin compounds was mildly decreased using liposomes carriers while Rh‐123 demonstrated no skin phototoxicity. DHE had the greatest tumoricidal effect among the porphyrin compounds. PHE has the potential of increased effect due to the ability to use higher light dosages in the activation of this porphyrin. Rhodamine‐123 had no tumor effect in this animal model. Clinical implications of phototherapy with these four compounds are addressed.
Nasopharyngeal carcinomas and malignant lymphomas: An immunohistochemical analysis of 74 cases
Authors: Sugimoto Takuya , Hashimoto Hiroshi , Enjoji Munetomo 
Published: October 2006

AbstractSeventy‐four cases of nasopharyngeal malignant neoplasms were analyzed immunohistochemically and classified into 16 lymphomas and 58 carcinomas. Eight lymphomas were of T‐cell origin and eight were of B‐cell origin. Although there were no significant differences in prognoses between patients with carcinoma and those with lymphomn, T‐cell lymphomas resulted in a worse outcome. Five‐year survival rates of T‐cell and B‐cell Iymphoma were 12.5% and 75%, respectively. Polyclonal keratin and tissue polypeptide antigen were more sensitive and specific than other epithelial markers, and were positive in 97% (56 of 58) and 93% (54 of 58) of carcinomas, respectively. With regard to immunophenotypic analysis of malignant lymphomas, L26 to B‐cells (88%) and UCHL1 to T‐cells (100%) led to a satisfactory effect. Immunohistochemical investigations made possible differentiation of malignant lymphomas from a carcinoma and also aided in typing the latter.
Pediatric penetrating head and neck trauma
Authors: Stephen Martin W. , Gussack Gerald S. 
Published: October 2006

AbstractPenetrating head and neck trauma in children causes uncommon and potentially life‐threatening injuries. We reviewed the charts of 21 patients who sustained penetrating injuries to the face or upper neck. Seventeen males and 4 females, aged 32 weeks' gestation to 19 years (mean = 10.2 years) comprised the study population. There were 15 gunshot wounds, 1 shotgun injury, and 5 stab wounds. Significant problems included 7 vascular injuries, 6 central nervous system injuries, 5 ocular injuries, 3 airway compromises, 2 facial nerve injuries, 1 cervical esophageal penetration, and 2 cases of pneumothorax. Three deaths occurred, but the majority of the patients survived and sustained minimal permanent disability. Included in this review is a unique case of an intrauterine gunshot wound to the face at approximately 32 weeks' gestation. The treatment protocol, differences from adult patients, and management highlights are reviewed.
Selective management of early glottic cancer
Authors: Kim Davis R. , Kelly Steven M. , Parkin James L. , Stevens Michael H. , Johnson Leland P. 
Published: October 2006

AbstractSeventy patients with stage I and II glottic cancer were treated at the University of Utah School of Medicine hospitals from 1980 through 1987. Forty‐four patients had stage I cancer and 26 patients had stage II. The overall survival in the stage I group was 82%. Primary site control was 93% with only three deaths due to laryngeal cancer. Local control rates were 93% with CO2 laser excision, 80% with CO2 laser and irradiation, and 67% with radiation alone.Stage II glottic patients had an overall survival of 61.5% with a local control rate of 76%. Twenty‐one of 24 patients were treated by full‐course irradiation. Of the eight patients who recurred at the primary site, all were irradiation failures who had initial bulky disease and impaired vocal cord mobility.Selective CO2 laser excision was highly effective, whereas radiation therapy results were somewhat disappointing. Open partial laryngectomy should be considered in bulky stage II disease patients.
The melanocyte and melanoma
Authors: Conley John 
Published: October 2006

AbstractThis paper reviewed some of the interesting biological aspects of melanocytes and their relationship to the nevus and to melanoma. It also proposed a rationale for “adequate” surgery in the management of melanoma according to level, depth, margins, and trends in treatment. These propositions were derived from an analysis of 995 cases of melanoma of the head and neck.
Allograft tympanoplasty: Predictive value of preoperative status
Authors: Claes J. , Van De Heyning P. H. , Koekelkoren E. , Van Laer C. , De Saegher D. , Graff A. , Creten W. 
Published: October 2006

AbstractThe functional and anatomical results of a series of 181 consecutive allograft tympanoplasties for ears with drum perforation and an intact ossicular chain were retrospectively reviewed and related to preoperative factors. Drum closure was realized in 92% (166 of 181 cases evaluated 1 year after surgery), and 96.6% of the reconstructed drums were still intact 3 years after surgery (118 cases evaluated). An air‐bone gap of less than 21 dB was reached in 79.6% (of a total of 162 cases) 1 year after surgery, and in 78% (of a total of 118 cases) 3 years after surgery. Age, contralateral pathology, the wet or dry status of the ear preoperatively, and the preoperative air‐bone gap had no influence on anatomical results. The preoperative air‐bone gap did not predict the postoperative air‐bone gap. The influence of age and existence of contralateral pathology on hearing gain was only visible in some of the strictly defined patient groups. The wet preoperative status of the ear generally predicted lower functional gain.
Isolated congenital stapes ankylosis: Surgical results in 32 ears and a review of the literature
Authors: Teunissen Bert , Cremers W. R. J. , Huygen Patrick L. M. , Pouwels Ton P. B. M. 
Published: October 2006

AbstractIsolated congenital stapes ankylosis is described in 32 operated ears from 28 patients. In 27 ears, a regular sta‐pedectomy was performed. In the remaining 5 ears, 2 had stapes gushers, 2 had bony stapedial tendons, and 1 had an aberrant facial nerve crossing the oval window.The average individual hearing gain was 20 dB. The mean hearing gain for the 24 successful stapedectomies was 29 dB.In 24 of 32 ears (75%), an essential hearing gain of at least 15 dB Fletcher's index hearing threshold could be achieved. A Fletcher's index not exceeding 30 dB could be achieved in 19 of 32 ears (60%), in spite of several cases with a sensori‐neural component in the hearing loss.A review of the literature and overview of longer series with isolated congenital stapes ankylosis is presented.
Effect of Enzyme Replacement Therapy With Imiglucerase on BMD in Type 1 Gaucher Disease
Authors: Wenstrup Richard J , Kacena Katherine A , Kaplan Paige , Pastores Gregory M , Prakash-Cheng Ainu , Zimran Ari , Hangartner Thomas N 
Published: October 2006

Abstract
The effect of ERT with imiglucerase on BMD in type 1 GD was studied using BMD data from the International Collaborative Gaucher Group Gaucher Registry. Data were analyzed for 160 untreated patients and 342 ERT-treated patients. Imiglucerase significantly improves BMD in patients with GD, with 8 years of ERT leading to normal BMD.
Introduction: The objective was to determine the effect of enzyme replacement therapy (ERT; Cerezyme, imiglucerase) on BMD in type 1 Gaucher disease (GD).
Materials and Methods: The study population included all adults (men, 18–70 years; women, 18–50 years) enrolled in the International Collaborative Gaucher Group (ICGG) Gaucher Registry for whom lumbar spine BMD measurements were available. BMD data with up to 8 years of follow-up were analyzed for 160 patients who received no ERT and 342 patients treated with ERT alone. BMD was assessed by DXA of the lumbar spine. Z scores for patients with GD were compared with a reference population. From the model's estimate, percent of patients by age and sex with osteoporosis (T score ⩽ −2.5) were calculated.
Results: DXA Z scores for patients with GD in the no ERT (untreated) group were significantly below normal (y intercept = −0.80 Z score units, p &lt; 0.001) and remained ˜1 SD below the reference population over time (slope = −0.010 Z score units per year, p = 0.68). The DXA Z scores for patients with GD who received ERT at a dose of 60 U/kg/2 weeks were significantly lower than the reference population at baseline (y-intercept = −1.17 Z score units, p &lt; 0.001), but improved significantly over time (slope = +0.132 Z score units per year, p &lt; 0.001). A significant dose–response relationship was noted for the ERT group, with the slopes for the three main dosing groups of 15, 30, and 60 U/kg/2 weeks of +0.064, +0.086, and +0.132 Z score units per year, respectively. The BMD of patients with GD treated with ERT increased to −0.12 (60 U/kg/2 weeks), −0.48 (30 U/kg/2 weeks), and −0.66 (15 U/kg/2 weeks) SD of the mean of the reference population after 8 years of ERT, approaching the reference population. Estimated risk of osteoporosis of this GD population, if left untreated, ranged from ˜10 to 30% in women and 10% to 25% in men.
Conclusions: ERT with imiglucerase (Cerezyme) may increase BMD in patients with GD. Response to treatment with imiglucerase is slower for BMD than for hematologic and visceral aspects of GD. A normal (age- and sex-adjusted) BMD should be a therapeutic goal for patients with type 1 GD.
Inhibition of the ubiquitin-proteasome system: a new avenue for atherosclerosis
Authors: Tan Chunjiang , Li Yuguang , Tan Xuerui , Pan Hongxin , Huang Wen 
Published: October 2006

Abstract

Background: The ubiquitin-proteasome system (UPS) is thought to be functionally active in atherosclerosis (AS) lesions. Aspirin was found to be a potent inhibitor of the UPS in some tumour studies; however, its effect on AS remains to be demonstrated in vivo.

Methods: New Zealand rabbits were placed on a normal diet (N) or on a normal diet with aspirin (NI) or on an atherogenic diet without (H) or with aspirin (HI) for 12weeks. Proteasome activity, concentrations of plasma lipids and levels of peroxidation were determined. Ubiquitin/ubiquitin-conjugates (Ub), IκBα, phosphorylated IκB (pIκBα) and p65 were investigated by Western blotting or immunochemistry.

Results: Concentrations of plasma lipids and peroxidation levels were higher in H or HI vs. N or NI. Histological analysis showed that atheroma was increased in H. Ub and IκBα were mainly localised in subendothelium and media vascular smooth muscle cells. Western blots revealed that Ub, IκBα, and pIκBα were increased, whereas p65 was lower in HI vs. H. The activity of the 20S proteasome was functionally active in H vs. N, NI or HI, while the 26S proteasome was not affected in any of the groups.

Conclusions: Aspirin can attenuate the pathogenesis of atheroma formation, the degradation of IκBα and pIκBα, and lower the expression of p65, indicating that its therapeutic effects on AS may be via inhibition of the UPS.
Clin Chem Lab Med 2006;44:1218–25.
Multicentre evaluation of a new point-of-care test for the determination of NT-proBNP in whole blood
Authors: Zugck Christian , Nelles Manfred , Katus Hugo A. , Collinson Paul O. , Gaze David C. , Dikkeschei Bert , Gurr Eberhard , Hayen Wiebke , Haass Markus , Hechler Christoph , van Hoof Viviane , Guerti Khadija , van Waes Carl , Printzen Gert , Klopprogge Kai , Schulz Ilse , Zerback Rainer 
Published: October 2006

AbstractClin Chem Lab Med 2006;44:1269–77.
Paraoxonase-1 (PON1) activity, but not PON1Q192R phenotype, is a predictor of coronary artery disease in a middle-aged Serbian population
Authors: Kotur-Stevuljevic Jelena , Spasic Slavica , Stefanovic Aleksandra , Zeljkovic Aleksandra , Bogavac-Stanojevic Natasa , Kalimanovska-Ostric Dimitra , Spasojevic-Kalimanovska Vesna , Jelic-Ivanovic Zorana 
Published: October 2006

AbstractClin Chem Lab Med 2006;44:1206–13.
Role of serum S100B as a predictive marker of fatal outcome following isolated severe head injury or multitrauma in males
Authors: da Rocha Adriana Brondani , Schneider Rogerio Fett , de Freitas Gabriel R. , André Charles , Grivicich Ivana , Zanoni Caroline , Fossá Aline , Gehrke Junia T. , Pereira Jotz Geraldo , Kaufmann Mauro , Simon Daniel , Regner Andrea 
Published: October 2006

AbstractClin Chem Lab Med 2006;44:1234–42.
Apolipoprotein B gene 3′VNTR polymorphism: association with plasma lipids and coronary heart disease in Han Chinese
Authors: Yan Sheng-kai , Song Yao-hong , Zhu Wen-ling , Yan Xiao-wei , Xue Hong , Du Hong , Chen Bao-sheng 
Published: October 2006

AbstractClin Chem Lab Med 2006;44:1199–205.
Frequency of a single nucleotide (A2317G) and 56-bp variable number of tandem repeat polymorphisms within the deoxyribonuclease I gene in five ethnic populations
Authors: Fujihara Junko , Yasuda Toshihiro , Shiwaku Kuninori , Takeshita Haruo 
Published: October 2006

AbstractClin Chem Lab Med 2006;44:1188–91.
The importance of metrological traceability on the validity of creatinine measurement as an index of renal function: International Federation of Clinical Chemistry and Laboratory Medicine (IFCC)
Authors: Panteghini Mauro , Myers Gary L. , Miller W. Greg , Greenberg Neil 
Published: October 2006

AbstractThe glomerular filtration rate (GFR) is currently considered the best overall index of kidney function. The possibility that laboratories might routinely report an estimated GFR has become practically feasible with the development of a formula, the “four-variable” Modification of Diet in Renal Disease study (MDRD) equation that uses age, sex, race, and serum creatinine parameters. However, a limitation of this equation for general implementation in healthcare is related to the use of differently calibrated creatinine measurement procedures among laboratories. The only way to achieve universal implementation of the GFR prediction equation, with the associated clinical benefits for patients, is, therefore, to promote worldwide standardization of methods to determine creatinine, together with the introduction of a revised GFR-estimating equation appropriate for use with standardized creatinine methods.Clin Chem Lab Med 2006;44:1287–92.
Symmetry reduction and cation ordering in solid solution of stronium-lead and barium-lead nitrates
Authors: Shtukenberg Alexander G. , Euler Harald , Kirfel Armin , Popov Dmitry Yu. 
Published: October 2006

Abstract
Kinetic ordering of the cations in (Sr,Pb)(NO3)2 and (Ba,Pb)(NO3)2 solid solutions with anomalous birefringence was studied by means of single crystal X-ray diffraction. The crystal structures of two samples of (Sr0.62Pb0.38)(NO3)2 and (Ba0.20Pb0.80)(NO3)2, respectively, taken from the {111} growth sectors as well as of two samples of (Sr0.62Pb0.38) (NO3)2 taken from the {100} growth sector were refined in the ideal structure space group Pa-3 and in two of its subgroups – trigonal R-3 and triclinic P-1 with R = 0.009 — 0.027. The final choice of trigonal symmetry for the samples from the {111} growth sectors is based on the analysis of the diffraction patterns and of the cation distributions over the crystallographic sites, which reflects the different orientations of the cation coordination polyhedra with respect to the (111) growth face (cubic setting). The observed optical indicatrices were successfully reproduced in the point-dipole approximation.
The crystal structures of polymorphic SUZ-4
Authors: Strohmeier Karl G. , Afeworki Mobae , Dorset Douglas L. 
Published: October 2006

Abstract
SUZ-4 is an aluminosilicate zeolite originally synthesized at British Petroleum and known to be related somehow to ferrierite. Although a model had been suggested for the framework structure no quantitative proof of its existence has been given in previous work. It is now found to be polymorphic. The originally identified ambient, hydrated form crystallizes in space group Imma where a = 18.882(1), b = 14.872(1), c = 14.211(1) Å. A model constructed by trial and error refines by Rietveld methods to give Rwp
= 0.1643, R(F
2) = 0.1665. Powder data collected at 100 °C, on the other hand, correspond to the Cmmm model proposed earlier by Lawton et al., where a = 18.790(1), b = 14.2305(8), c = 7.4511(4) Å. The Rietveld match gives Rwp
= 0.1473, R(F
2) = 0.1508. Although the two forms crystallize in different space groups, the framework topology remains the same, as revealed by vertex symbols and coordination sequences. Evidence is seen for potassium ions that cannot be completely removed by ammonium exchange. Later, the origin of the polymorphic change was discovered to be hydration of microporous channels rather than a thermal effect. Solid-state NMR measurements of the hydrated and anhydrous forms show that a more symmetric environment around the Al species is observed without affecting the coordination of the Al sites. Synchrotron powder data collected at room temperature from anhydrous material conformed to the Cmmm structural model, where a = 18.8064(4), b = 14.2298(3), c = 7.4548(2) Å. Rietveld refinement, including three potassium sites gives R
wp = 0.1127, R(F
2) = 0.1296. (Elemental analysis indicates a stoichiometric assembly: K4T36O72; the Rietveld refinement finds 3.86 of the 4.00 potassium atoms.) The material represents a one-dimensional 10-membered ring framework.
A crystallographic and spectroscopic study on the imine-amine tautomerism of 2-hydroxyaldimine compounds
Authors: Nazir Hasan , Arici Cengiz , Emregül Kaan C. , Atakol Orhan 
Published: October 2006

Abstract
The molecular structures of N-(2-hydroxy ethyl)-3,5-dinitrosalicylaldimine and N-N′-bis(acetophe-nylketimine)-1,4-diaminobuthane were determined using X-ray diffraction. It was established using the difference Fourier map that the phenolic hydrogens were situated on the iminic nitrogen. Identical observations of the molecular structure were made for similar Schiff bases in literature, and it was established that this situation was not in agreement with the IR and NMR results. The molecular structure of N-(4-hydroxylphenyl)-benzaldimine was determined using X-ray diffraction for comparison. Similar compounds were prepared and their FTIR spectra were investigated.
Long-term Follow-up after Maxillary Distraction Osteogenesis in Growing Children with Cleft Lip and Palate
Authors: Huang Chiung-Shing , Harikrishnan Pandurangan , Liao Yu-Fang , Ko Ellen W. C. , Liou Eric J. W. , Chen Philip K. T. 
Published: October 2006

Objective: To evaluate the changes in maxillary position after maxillary distraction osteogenesis in six growing children with cleft lip and palate. Design: Retrospective, longitudinal study on maxillary changes at A point, anterior nasal spine, posterior nasal spine, central incisor, and first molar. Setting: The University Hospital Craniofacial Center. Main Outcome Measure: Cephalometric radiographs were used to measure the maxillary position immediately after distraction, at 6 months, and more than 1 year after distraction. Results: After maxillary distraction with a rigid external distraction device, the maxilla (A point) on average moved forward 9.7 mm and downward 3.5 mm immediately after distraction, moved backward 0.9 mm and upward 2.0 mm after 6 months postoperatively, and then moved further backward 2.3 mm and downward 6.8 mm after more than 1 year from the predistraction position. Conclusion: In most cases, maxilla moved forward at distraction and started to move backward until 1 year after distraction, but remained forward, as compared with predistraction position. Maxilla also moved downward during distraction and upward in 6 months, but started descending in 1 year. There also was no further forward growth of the maxilla after distraction in growing children with clefts.