bluuebunny/crossref_metadata_2025_split huggingface dataset:
Significance of the “maturation” of metastases from Wilms' tumor after therapy
Authors: Omar Rawhi , Davidian Marianna M. , Marcus Judith R. , Rose Judith 
Published: February 2007

AbstractSeveral metastatic nodules were discovered in the lungs of a 4‐year‐old boy two years after surgical excision of Wilms' tumor with subsequent chemotheraphy and local irradiation. All these metastatic nodules were composed of differentiated mesenchymal elements similar to those encountered in the primary neoplasm. Similar “mature” metastases have been observed by pathologists in other tumors of embryonic origin. Review of available literature and clinical and experimental data supports the notion that “reversion” of malignant cells into phenotypically benign counterparts may take place spontaneously or under the influence of environmental factors. Anticancer agents (cytostatics, radiation) selectively destroy the more anaplastic cells present in a malignant tumor (or its metastatic implants), thus allowing the “benign” revertants to predominate. Although such lesions are benign‐appearing, it is recommended that they be completely excised; however, but further chemo‐ or radiotherapy may not be necessary.
Symptomatic granular cell tumor of the esophagus
Authors: Sarma Deba P. , Rodriguez Fred H. , Deiparine Erico M. , Weilbaecher Thomas G. 
Published: February 2007

AbstractA case of symptomatic granular cell tumor of the esophagus is described. Another 32 cases collected from the English literature are analyzed. The reported cases have occurred mostly in women of less than 50 years of age presenting with dysphagia. Excision of the lesion is curative.
Proposed method to study the factors affecting local control with combined external beam and interstitial implantation of mobile tongue and floor of mouth
Authors: Hintz Brace L. , Kagan A. Robert , Chan Paul , Rao Aroor R. , Nussbaum Herman , Ryoo Monica C. , Wollin Myron 
Published: February 2007

AbstractTwenty‐seven patients with squamous cell carcinoma of the mobile tongue and floor of the mouth were treated with external beam and interstitial radiation. Good prognostic factors were T1N0, T2N0, superficial tumors, tumor shrinkage by 75% with external beam, and no apparent tumor clinically 2 months after treatment. On the other hand, T3N0, T1‐3N1, and deeply necrotic tumors had a poor prognosis. We recommend using a flexible afterloading system to implant the initial local tumor volume (not just the residual nidus) that does not exceed 45 cm3. The minimum (reference) dose was prescribed to a surface 1/2 cm beyond the most peripheral rim of radioactive sources. For acceptable local control and complication rates, our suggested minimum (reference) doses are ⩽7,500 rads for T1 (or a time‐dose‐fractionation [TDF] of 131‐140), <8,000 rads for T2 (TDF of 131‐140), and probably < 8,500 rads for T3 (TDF of ⩽ 150). These guidelines should be considered preliminary.
What is the value of the computer for the physician?
Authors: Juckett Mark , Spratt John S. 
Published: February 2007

AbstractComputer technology is advancing at an increasingly rapid rate. Although the computer's former role in the health care field was primarily limited to the financial and marketing departments of health care facilities, the computer is moving beyond the managerial departments and into the realm of the practicing physician. Much of this change in the use of computers in this field is due to the pressures of cost containment, DRG requirements, the availability of microcomputers, and the desire for improved health care. In the areas of clinical care, medical research, and medical education, the computer is rapidly becoming an indispensable tool through its technological adaptation. The computer is an obvious adjunct to the problem of improving cost efficiency without compromising the efforts toward better health care.
Carcinoma of the extrahepatic bile ducts: A postmortem study of 65 cases and review of the literature
Authors: Sons H. U. , Borchard F. 
Published: February 2007

AbstractFrom 1950 to 1982, 65 patients with carcinoma of the extrahepatic bile ducts were autopsied in the Institute of Pathology of the University of Düsseldorf. The average age of men was 64.5 years and that of women was 70 years. The ratio of men to women was 1 to 1.71. The greatest number of tumors was found in the common bile duct (40.1 %), followed by the hepatic ducts (29.2%) and the confluence of the common hepatic duct with the cystic duct (27.7%). Adenocarcinomas of various differentiation were found in 96.7% of the cases and anaplastic carcinoma in 3.3%. Metastases were present in 49 cases (75.4%). Cholelithiasis was found in 51 % of the cases. The results of the present postmortem study are compared with the literature.
Lung cancer in men aged 75 or older
Authors: Sarma Deba P. 
Published: February 2007

AbstractSixty‐seven cases of lung cancer occurring in men aged 75 or older were examined at autopsy. There is a similar incidence of epidermoid and small cell carcinoma, but a lower incidence of adenocarcinoma and a slightly higher incidence of large cell carcinoma in this elderly group of patients compared to the incidence of various histologic types occurring in patients of all ages. The various organs involved by metastatic tumor are similar to those seen in lung cancer in general; the overall metastatic disease is less widespread in the older group.
Malignant fibrous histiocytoma of the breast with axillary lymph node involvement
Authors: Van Niekerk J. L. M. , Wobbes Th. , Holland R. , Van Haelst U. J. G. 
Published: February 2007

AbstractThis case history describes a 70‐year‐old female patient with a malignant fibrous histiocytoma (MFH) of the breast with secondary involvement of the skin and axillary lymph node metastases. We think that in die case of a MFH of the breast a radical or modified radical mastectomy should be pursued instead of a simple mastectomy.
Primary choriocarcinoma of mediastinum with immunohistochemical study and review of the literature
Authors: Kathuria Satinder , Jblokow Victor R. 
Published: February 2007

AbstractPrimary germinal tumors of the mediastinum are extremely rare. Most germ cell tumors in that location occur as metastasis from testis. A case report with immunocytochemical studies is described. Histologically, the tumor had features of choriocarcinoma and with immunoperoxidase technique stained positively for Beta human chorionic gonadotropin (BHCG). The patient is alive and asymptomatic 2 years post surgery and chemotherapy.
The effect of ionizing radiation on the primate pancreas: An endocrine and morphologic study
Authors: Du Toit Don F. , Heydenrych Jacobus J. , Smit Ben , Zuurmond Theuns , Louw Gabriel , Laker Lida , Els Daniel , Weideman André , Wolfe‐Coote Sonja , Du Toit Lorraine B. , Davids Henry , Groenewald Wilhelm A. , van der Merwe Emuel , Pistorius Stephen 
Published: February 2007

AbstractIn this study we evaluated the endocrine, biochemical, and haematological derangements as well as pancreatic and histological changes of the bone‐marrow in the primate following external fractionated subtotal marrow irradiation without bonemarrow reconstitution. The irradiation was administered in preparation for pancreatic transplantation. Two groups of animals (ten in each group) received 800 rad (8 Gy) and 1,000 rad (10 Gy) respectively over 4 to 5 weeks. A maximum of 200 rads (2 Gy) were administered weekly as photons from a 6 MV linear accelerator. During irradiation the animals remained normoglycaemic in the presence of transiently elevated liver enzymes and serum amylase values, which returned to normal on completion of the irradiation. Insulin release was significantly reduced in both groups during irradiation and was associated with minimally decreased K‐values in the presence of mild glucose intolerance. Pancreatic light morphologic changes included structural changes of both exocrine and endocrine elements and included necrosis of the islet cells and acinar tissue. Islet histology demonstrated striking cytocavitary network changes of alpha and beta cells, including degranulation, vacuolization, mitochondrial destruction, and an increase in lysosomes. A hypoplastic bonemarrow ranging from moderate to severe was observed in all irradiated recipients. Near total fractionated body irradiation in the primate is therefore associated with elevated liver enzymes, pancytopenia, transient hyperamylasaemia, hypoinsulinaemia, a varying degree of pancreatitis, and bonemarrow hypoplasia.
Shoulder flap for head and neck reconstruction: An alternative when everything else fails
Authors: Cohen Mimis 
Published: February 2007

AbstractThe use of axial and free flaps made the use of delayed random flaps for the reconstruction of the head and neck almost obsolete. Immediate reconstruction of intraoral defects using the pectoralis major musculocutaneous flap primarily, as well as other axial or free flaps, has become a common practice. However, in some selected cases due to failure of previous operations or complications of radiation and recurrence, the reconstructive surgeon is left with very little choice. The purpose of this paper is not to advocate the use of the shoulder flap as a primary reconstructive procedure, but to call attention to its availability for certain complicated cases and briefly described the details of the technique.
Diagnostic evaluation and survival analysis of colorectal cancer patients with liver metastases
Authors: De Brauw L. M. , Van de Velde C. J. H. , Bouwhuis‐Hoogerwerf M. L. , Zwaveling A. 
Published: February 2007

AbstractClinical features and their prognostic value were evaluated in 83 colorectal cancer patients with liver metastasis. The clinical features analysed included presenting symptoms and signs, liver function tests, extent of liver involvement, associated extrahepatic tumor growth, and physical condition of the patients. Overall median survival time after diagnosis of liver metastases was 8.4 months. Prognostic factors related to survival were symptoms, when referable to liver metastasis, and 5′ Nt. Information is supplied to survey what selection of patients should be considered for various treatment options. A predominance of the patients showed bilobar liver involvement (79.6%), extrahepatic tumor growth (49.4%), or had an unresectable primary tumor (30.1%), thus leaving only 6% of the patients with liver metastases for surgical treatment with the intention of cure.
Pulmonary blastoma in childhood
Authors: Jimenez Jorge F. 
Published: February 2007

AbstractPulmonary blastoma (PB) has been considered a very rare primary lung malignant neoplasm. In children, it is one of the rarest cancers reported. To my knowledge, there are only 24 pediatric cases of PB in patients ranging from 2 months to 15 years of age, representing one‐fourth of all reported cases in the literature. The association of PB with an underlying abnormal pulmonary morphogenesis, characterized by “cystic lesions,” suggests that there is a teratogenic‐oncogenic relationship. Review of me literature and the clinical and pathologic features of PB in a 2‐1/2‐year‐old white female are discussed.
Serum vitamin B12 levels in patients with primary hepatocellular carcinoma during treatment with CB3717
Authors: Buamah Paul K. , James Oliver F. W. , Skillen Andrew W. , Harris Adrian L. 
Published: February 2007

AbstractElevated Serum B12 levels were found at diagnosis in five of eleven patients with primary hepatocellular carcinoma. During chemotherapy either with CB3717 or VP16 the serum B12 rose dramatically, in one case reaching levels ten times the upper limit of normal. However, the serum LD activities did not change in parallel with the serum B12 levels suggesting that there was little necrosis of the tumour or the liver. With two out of five patients with other types of cancer the serum B12 levels also increased but less markedly. This data seems to suggest that the serum B12 level may not be as good a tumour marker for hepatocellular carcinoma as has been suggested and indeed may be influenced by the chemotherapeutic agent.
Uterine sarcoma: A retrospective study
Authors: Wen B‐Chen , Tewfik Ferial A. , Tewfik Hamed H. , Long Jeffrey P. , Anderson Barrie 
Published: February 2007

AbstractFrom 1965 to 1982, 86 analyzable patients with uterine sarcoma were treated. Nineteen patients (22%) presented with advanced disease. For the patients with curable diseases (67 patients), the disease‐free survivals with a median follow‐up of 4.5 years are 40% (surgery only), 53% (surgery + chemotherapy), 46% (surgery + radiation ± chemotherapy). The local failure rates are 43%:32%:33%, respectively. There is no statistical significance. The most important prognostic factor is the clinical extent of the tumor. The role of radiation therapy and chemotherapy will be discussed.
Effect of route of administration on the selectivity of hematoporphyrin derivative for tumor tissue
Authors: Elmer Edward B. , Wood William C. , Cohen Alfred M. , Bamberg Michael 
Published: February 2007

AbstractHematoporphyrin derivative (HPD) has the ability to localize with moderate selectivity to tumor tissue, where it can be activated by visible light and produce singlet oxygen‐mediated damage to cellular biomolecules. However, HPD is less than ideal as an agent for tumor photoradiation therapy because it produces a period of photosensitivity that can last 30 days or more, and it can be toxic to surrounding tissues such as skin when used in the treatment of subcutaneous metastases. The usefulness of intra‐arterial injection for refining the selectivity of HPD was investigated in this work. Intraarterial administration of HPD was not found to provide higher tumor levels of HPD, nor was it able to increase significantly the concentration of HPD relative to surrounding tissues, such as skin and muscle. However, fluorescence microscopy findings suggested that some fluorescent HPD component is rapidly accumulated in tumor macrophages following intraarterial injection.
Selection of optimal therapy for neuroblastoma: A Study of the Immunomodulatory Effects of Surgery and Irradiation in the Murine C1300 Neuroblastoma Model
Authors: Topalian Suzanne L. , Ziegler Moritz M. 
Published: February 2007

AbstractHuman neuroblastoma is an immunogenic tumor for which therapy directed in an immunologic context may offer some advantage over conventional treatment. This study examines the immunomodulatory effects of surgery and irradiation in the murine C1300 neuroblastoma model. In vivo studies of primary tumor growth characteristics after treatment demonstrated no superiority of either therapeutic modality in control of local tumor or prolongation of host survival. However, irradiated hosts showed an increased ability to reject a secondary tumor challenge, compared to their surgical counterparts. That this phenomenon may be immune‐related is suggested by in vitro studies of T lymphocyte function utilizing mixed lymphocyte‐tumor cell cultures and PHA lymphoblastogenesis.
Classification of vacuolated cells in the gastric mucosa
Authors: Rubio C. A. , Kato Y. 
Published: February 2007

AbstractFive different types of vacuolated cells occurring in the gastric mucosa were described. In haematoxylin‐eosin stained preparations, one type was characterized by supranuclear clear vacuoles, the other by supranuclear dark vacuoles, another by usually supranuclear vacuoles and cilia, a fourth type by subnuclear clear vacuoles centered by a lymphocyte, and the fifth type by subnuclear empty vacuoles. In the latter three types, a battery of mucous stains were negative. The significance of some of these vacuolated cell types remains to be elucidated.
Tumor stabilization after hyperthermia: An important criterion of response to thermal therapy
Authors: Storm F. Kristian , Scanlon Edward F. , Baker Harvey W. , Roe Denise , Morton Donald L 
Published: February 2007

AbstractSeveral investigators have indicated that changes in tumor size may not occur after hyperthermia therapy even with substantial tumor cell kill, because of early edema and subsequent fibrosis of background stroma, suggesting that “tumor stabilization” might be an important benefit of thermal therapy. Recently, 9 institutions completed a national cooperative study of localized hypetthermia for patients with advanced, recurrent, or metastatic solid cancer that evaluted the potential significance of this response variable in a standardized clinical trial. Of 960 evaluable patients who completed at least one course of hyperthermia, thermoradiotherapy, or thermochemotherapy, 85 (9%) had complete responses for 1‐34 months, 173 (18%) had partial responses for 1‐39 months, 95 (10%) had minimal responses for 1‐15 months, and 313 (33%) had disease stabilization for 1‐32 months. Of 313 patients who had no change (i.e., ± 25%) in the size of their tumors after hyperthermia, the response lasted only 1‐3 months in 170 (54%) patients, a finding of questionable clinical significance. However, disease stabilization was observed for more than 3 months in 143 (46%), for more than 6 months in 67 (21 %), more than 9 months in 33 (10%), and more than 12 months in 16 (5%). Disease stabilization was also associated with improved activity for 1‐22 months in 79 (25%) of these patients, and improved pain for 1‐22 months in 100 (32%). Disease stabilization appeared to be independent of tumor histology, location, or depth within the body, size, or minimum treatment temperature, but was somewhat more frequent after hyperthermia combination therapy. There is sufficient accumulative data to suggest that tumor stabilization after hyperthermia should not be dismissed as a placebo effect. This response variable well may be a unique and potentially important criterion of response to localized hyperthermia therapy.
Diagnosis of pulmonary nodules in the cancer patient: The role for routine culture and an unusual application of the human tumor colony‐forming assays
Authors: Friedman Howard M. , Johnston Michael , Macher Abe M. , Glaubiger Daniel 
Published: February 2007

AbstractMany solid tumors that occur in humans tend to metastasize to the lungs. The etiology of pulmonary nodules in cancer patients, therefore, presents a diagnostic problem that can be resolved only by histologic evaluation or resection. We present two cases of cancer patients with preoperative and intraoperative diagnoses of metastatic lung tumors. Tissue culture using the Human Tumor Colony‐Forming Assay (HTCFA), a procedure that predicts chemosensitivity patterns of tumors, was employed to successfully diagnose those nodules as fungal infections. In one case, results using the HTCFA were crucial in the identification of the opportunistic, organism. These cases stress the importance of routine culture of all pulmonary nodules and present an unusual but noteworthy application of the HTCFA system.
Liposarcoma of the spermatic cord: Case report and review of the literature
Authors: Torosian Michael H. , Wein Alan J. 
Published: February 2007

AbstractThis report describes a patient with liposarcoma of the spermatic cord. The clinical presentation, pathogenesis, and prognosis of this unusual sarcoma are reviewed. The low‐grade malignant potential and irregular growth characteristics of this liposarcoma render preoperative diagnosis difficult. The role of radical orchiectomy, retroperitoneal lymph node dissection, radiation therapy, and chemotherapy in the treatment of spermatic cord sarcomas is discussed.
Oncocytic pleomorphic adenoma of the parotid gland
Authors: Pulitzer Donald R. , Reitmeyer William J. 
Published: February 2007

AbstractA rare case of salivary gland pleomorphic adenoma, in which the majority of cells were oncocytic, is reported. The patient, a 53‐year‐old man, presented with a parotid gland mass that was otherwise asymptomatic. Surgical treatment consisted of a superficial parotid lobectomy. The specimen was prepared in standard fashion and studied by light and electron microscopy. The microscopic features were characteristic of salivary gland pleomorphic adenomas, however, both epithelial and “mesenchymal” elements were oncocytic. Such changes may occur focally in pleomorphic adenomas, but we were unable to find documentation of a wholly oncocytic variant in a review of the medical literature. From our clinical data and previous reports of pleomorphic adenomas with focal oncocytosis, it is concluded that such changes likely do not alter prognosis in affected patients. The possible significance of this lesion in regard to the histogenesis of salivary gland pleomorphic adenomas is discussed.
Nail‐bed melanoma
Authors: Klausner Joseph M. , Inbar Moshe , Cutman Mordechay , Weiss Gerald , Skornick Yehuda , Chaichik Samario , Rozin Ronald R. 
Published: February 2007

AbstractIn our series of 348 patients treated over a 10‐year period, six (1.7%) had their primary lesions in the nail bed. Five of the subungual melanomas occurred in the toes and one in the thumb. Four of the lesions were of the acral lentiginous type. The delay in diagnosis was 7 months to 6 years. Four of the patients presented with advanced, neglected tumors. One had distant metastases at diagnosis. The treatment was mainly surgical. Digital amputation was carried out for local control. Five patients underwent lymph node dissection and in three of them regional metastases were found. Of the four patients with regional and distant metastases at the time of diagnosis, three died within 6 to 60 months and the fourth is alive with metastatic spread. Of the two patients with melanoma confined to the nail bed, one is free of disease 50 months following diagnosis and the other suffered from a local recurrence and has been free of disease for 30 months following wide excision and limb perfusion.
Bronchial carcinoid with multiple aerogenous implanted foci
Authors: Suzuki Keiko , Kimula Yuji , Ogata Takesaburo , Nakagawa Haruo 
Published: February 2007

AbstractA case of bronchial carcinoid with intrapulmonary dissemination was demonstrated. A right upper lobectomy was performed because of an abnormal shadow in the lung detected by an X‐ray mass survey. A carcinoid tumor originated from the spur region of the right upper lobe bronchus. The tumor protruded into the bronchial lumen and also extensively expanded into the surrounding alveolar tissue. The tumor showed typical histological features of bronchial carcinoid with a mixed insular, trabecular, and glandular pattern. Multiple implanted foci of tumor cells were found in the periphery of the lobe. The implanted tumor cells replaced the alveolar epithelium without destruction of the alveolar structure, which suggests the possibility of aergenous spread of bronchial carcinoid. This is the first report on bronchial carcinoid with aerogenous spread.
Solitary pulmonary metastasis: An enigma
Authors: Salsali Morteza 
Published: February 2007

AbstractLung metastases, which are an expression of the new phase of the underlying neoplastic disorder, have been treated in the recent years by multiple disciplinary approach. When the metastases to the lungs are multiple, it is indicative of extensive tumor burden, and the organ plays an insignificant role in the distribution of the metastases in the different lobes of the lungs. However, when the pulmonary metastases appear after a prolonged disease‐free interval it becomes an enigma; when the metastases are solitary, the majority (over 80% in this series) are located in the upper zone of the lungs. This study of 28 patients with solitary lung metastases explores the possible etiology of this clinical observation and proposes that the pattern of perfusion and anatomopathological features of the upper lobes are the main reasons why these lobes are prevalently the sites for solitary lung metastases.