bluuebunny/crossref_metadata_2025_split huggingface dataset:
Simultaneous presentation of relapsing Hodgkin's disease and treatment‐related non‐Hodgkin's lymphoma
Authors: Perri Robert T. , Allen John I. , Oken Martin M. , Limas Catherine , Kay Neil E. 
Published: February 2007

AbstractA 55‐year‐old white man was diagnosed in 1975 with Hodgkin's disease stage IIA, mixed cellularity. He was treated with 4,500 rads to an inverted‐Y field followed by six cycles of MOPP and remained in complete remission. In 1983 a right axillary lymph node biopsy showed recurrent Hodgkin's disease, mixed cellularity. While receiving his initial chemotherapy he developed persistent epigastric distress. Endoscopic gastric biopsy demonstrated a diffuse large‐cell non‐Hodgkin's lymphoma. Surface marker studies confirmed the separate identity of these two malignant lymphoproliferative processes. This represents the first reported simultaneous occurrence of relapsing Hodgkin's disease with treatmentrelated non‐Hodgkin's lymphoma.
Adjuvant therapy of cutaneous malignant melanoma: A critical review
Authors: Koh Howard K. , Sober Arthur J. , Harmon David C. , Lew Robert A. , Carey Robert W. 
Published: February 2007

AbstractThe emergence of revised definitions for the high‐risk patient with cutaneous malignant melanoma prompts us to re‐examine the current status of adjuvant therapy in this disease. We wish to address the question, “once a cutaneous melanoma is surgically removed and the patient is currently free of disease but at high risk for metastases, what can be done to prevent recurrence”?
Multicentric reticulohistiocytosis and cancer: A case report and review of the literature
Authors: Nunnink Johannes C. , Krusinski Paul A. , Yates Jerome W. 
Published: February 2007

AbstractMulticentric reticulohistiocytosis (MR) is a syndrome characterized by papulonodular skin lesions, a debilitating polyarthritis, and characteristic histologic findings. It is a rare disorder with only 82 cases reported. Twenty‐eight percent had an associated neoplasm. Hematologic malignancies (four) and neoplasms arising from the breast (four), cervix (three), stomach (three), ovary (two), colon (two), lung (one), pleura (one), and from an unknown source (two) were all seen associated with MR. Eleven cases (including our own) were available for review. The papulonodular skin involvement was the initial manifestation (alone or concurrent with the polyarthritis) in 90% of our cases. The diagnosis of MR preceded that of the associated neoplasm in 73% of the cases. A case report is presented illustrating the relapse of MR before the clinical relapse of the associated tumor, and the response of both the tumor and MR to combination chemotherapy with cyclophosphamide, methotrexate, 5‐fluorouracil, and prednisone when prednisone and aspirin alone failed to relieve the symptoms of MR. Steroids were not beneficial in the patients reviewed. The best management of MR associated with a neoplasm is the best management of the primary neoplasm. Cytotoxic chemotherapy including cyclophosphamide should be considered if there is progression of the MR in order to control the symptoms of MR and prevent a progressive debilitating arthritis.
Salvage treatment for patient with multiple myeloma refractory to alkylating agents
Authors: Gomez German A. , Han Tin , Ozer Howard , Henderson Edward S. 
Published: February 2007

AbstractSixteen patients with multiple myeloma refractory to alkylating agents were treated with vincristine 0.25 mg/m2 i.v. on days 1 to 4 and prednisone 1 gm/m2 on days 1 and 3. Chemotherapy was repeated every 2 weeks. Of 15 evaluable patients, five achieved a partial response and four stable disease. Three patients with partial response and three with stable disease relapsed at 6, 7, and 16 and at 5, 9, and 10 months, respectively. The median survival for all patients was 10 1/2 months and it ranged from 1 to 21 + months. The median survival in responders was not reached at 13 months. Onset of antitumor effect was observed within the first 2 weeks. Symptomatic relief of bone pain was noted within 48 hours in responders and nonresponders. Improvement in bone marrow cellularity and decrease in plasma cell infiltration was documented in more than one‐half of the responders. Tolerance to the treatment was good. No hematologic or other significant toxicity was observed.
The use of chemotherapy for extraocular retinoblastoma
Authors: Pratt Charles B. , Crom Deborah B. , Howarth Cathryn 
Published: February 2007

AbstractAmong the 114 children with retinoblas‐toma seen at St. Jude Children's Research Hospital 1962–1984, 11 have received treatment with chemotherapy for measurable extraocular disease which was present at diagnosis (seven patients) or developed later during the subsequent course of their disease (four patients). Metastatic disease involved the brain and spinal fluid of four persons, the orbit of five, the bone marrow of five, lymph nodes of four, and soft tissues of three individuals at the time of their treatments. Single agents or combinations were used. Two patients with orbital extension of primary retinoblastoma developed complete responses following chemotherapy and subsequently received orbital irradiation, and have had long‐term disease‐free survival. Additional responses developed in patients who received vincristine, cyclophosphamide, adriamycin, cisplatin, VM‐26, and ifosfamide, singly or in combination. With future identification of effective chemotherapy, new studies may be focused upon patients with localized disease to reduce radiation dosage or the need for immediate surgical resection of all involved eyes.
Combination chemotherapy with mitomycin‐C, cisplatin, and vinblastine in the treatment of non‐small‐cell lung cancer
Authors: Niell Harvey B. , Griffin John P. 
Published: February 2007

AbstractThe drug combination of mitomycin‐C, cis‐platin, and vinblastine was administered to 30 patients with stage III non‐small‐cell lung cancer. All patients had a performance status of 50% or greater, had evaluable disease, and had not received previous chemotherapy. The overall response rate was 37% with responses seen in 7 of 18 (39%) squamous cell and 3 of 11 (27%) patients with adenocarcinoma of the lung. Mean survival was greater by 2 months in those patients with an objective response to chemotherapy (8.1 vs 5.5). Drug‐associated gastrointestinal toxicity was the most common side effect observed. This three‐drug combination appears to be an active regimen in the treatment of non‐small‐cell broncho‐genie carcinoma; however, altered dosage schedules should be examined in order to decrease drug‐related toxicity.
Chemotherapy‐associated Raynaud's phenomenon in a two‐year‐old girl
Authors: McGuire Warren A. , Passo Murray H. , Weetman Robert M. 
Published: February 2007

AbstractRaynaud's phenomenon occurred in a 2‐year‐old girl 17 months after starting multi‐agent chemotherapy for an endodermal sinus tumor of the vagina. Symptoms began 2 months after receiving her final dose of bleo‐mycin, and gradually resolved over a 6‐month period despite continuing vinblastine. Chemotherapy‐associated Raynaud's phenomenon appears to be unusual in young children, although mild episodes of vasospasm may not be reported by children or their parents. Specific questions regarding symptoms of Raynaud's phenomenon should be asked of all children receiving vinblastine and bleomycin therapy.
Natural history of histiocytosis X: A pediatric oncology group study
Authors: Berry D. H. , Gresik Mary V. , Humphrey G. Bennett , Starling Kenneth , Vietti Teresa , Boyett James , Marcus Robert 
Published: February 2007

AbstractThe best therapy for patients with histiocytosis X with disease involvement other than isolated bone lesions but without organ dysfunction is unclear. This retrospective study was undertaken to define the natural history of this group of patients.In 25 of the 92 studied patients, there was no progression of the disease after diagnosis. In 53 surviving patients, the disease either continuously progressed (40) or recurred intermittently (13), The onset of last disease activity was 24 months or less for 55% of these children. A fatal outcome occurred in 14 children. All of these children developed organ dysfunction and 11/14 died during or before the second year of disease. These three different outcomes could not be predicted from the parameters evaluated; however, the disease that never abated but was continuously active was associated with a suboptimal outcome, and the development of organ dysfunction was a grave prognostic sign.
Education in cancer prevention for primary care clinicians
Authors: Love Richard R. , Stone Howard L. , Hughes Barbara 
Published: February 2007

AbstractIn response to increased public interest in cancer prevention and rapidly escalating health care costs, the National Cancer Institute supported the development of cancer prevention courses for health professionals. A multidisciplinary group of physicians, behavioral scientists, and educators developed, field‐tested, revised, and evaluated a 12‐module, 24‐classroom‐hour clinical preventive oncology course for primary care physicians. A rationale for education in cancer prevention is presented, the new clinical discipline of preventive oncology is defined, and contributory disciplines are identified. A curriculum based upon detailed learning objectives is described, short‐term evaluation data are presented, and a methodology for incorporating a didactic course into a residency program is suggested. The positive reception given to this course by residents warrants optimism concerning application of a biopsychosocial or self‐regulative model rather than the traditional biomedical one to clinical medicine and its teaching.
Legionnaires' disease in patients with cancer
Authors: Nunnink Johannes C. , Gallagher James G. , Yates Jerome W. 
Published: February 2007

AbstractA 4‐year experience with Legionella pneumophila (LD) diagnosed in 36 patients with cancer was reviewed. Cancer patients represented 24% of the total population of patients acquiring LD during that time. Hematologic neoplasms (42%) and lung cancer (22%) accounted for the majority of afflicted patients. Nosocomial infections occurred in 42% of the patients evaluated. Several risk factors were assessed, and only neutropenia, and previous steroid therapy played a causal role (p < .05) when assessed in a retrospective case control fashion. Overall mortality in oncology patients with LD (53%) was high and underscores the need rapidly to diagnose and treat this entity. This mortality decreased after 1977 when an effective antibiotic was utilized. Mixed infections also played a major role in outcome and occurred in 31% of the 36 patients studied. The mortality in these cancer patients was 73%, and this emphasizes the need to exclude and treat concomitant bacterial or fungal infections.
Successful chemotherapeutic decompression of epidural malignant germ cell tumor
Authors: Gale Gordon B. , O'Connor Dennis M. , Chu Jen‐Yih , Tantana Supranee , Weber Thomas R. 
Published: February 2007

AbstractA patient with a sacrococcygeal malignant germ cell tumor developed epidural spinal cord compression syndrome 32 days after surgical resection of tumor. Rapid resolution of symptoms was observed after chemotherapy with vinblastine, bleomycin, and cisplatinum. There was no radiation therapy or laminectomy for spinal compression. The patient had an excellent neurological recovery without any sequelae from spinal compression. Chemotherapy alone is an excellent approach to the management of epidural compression by malignant germ tumor.
The clinical significance of blast cell morphology in childhood lymphoblastic leukaemia
Authors: Lilleyman J. S. , Hann I. M. , Stevens R. F. 
Published: February 2007

AbstractThe morphological classification of ALL based on the FAB co‐operative group's criteria is capable of identifying 10–15% of children with L2 disease who, given similar treatment, will fare less well than the 85–90% with the L1 variant. The significant features defining L2 morphology are a low cellular nuclear: cytoplasmic ratio and the presence of nucleoli.Children with L2 disease do not have higher leucocyte counts but are older, have “common” ALL less frequently, and more often have well‐preserved marrow function at diagnosis. Their poor outlook is manifest not only by their higher relapse rate but also by a higher proportion failing to remit in the first instance. L2 morphology does not necessarily “breed true” and can arise in a small proportion of patients with previous L1 disease at the time of relapse.Other striking morphological features of lymphoblasts, including azurophil granules, vacuoles and “hand mirror” cells, have yet to have their significance defined, though the latter feature may be an unfavourable finding.
Procarbazine‐induced interstitial pneumonitis with a normal chest X‐ray: A case report
Authors: Garbes Isosceles D. , Henderson Edward S. , Gomez German A. , Bakshi Suraj P. , Parthasarathy K. L. , Castillo Nieva B. 
Published: February 2007

AbstractPulmonary toxicity due to cytotoxic drugs is well described in the literature. This is most commonly described in association with bleomycin, busulfan, and methotrexate. This report presents a case of interstitial pneumonitis with a normal chest x‐ray that is most certainly due to procarbazine. In addition, the role of gallium‐67 citrate scintigraphy in early diagnosis is discussed. This is especially important since discontinuation of the drug before radiographic manifestations of pulmonary toxicity become evident may prevent permanent pulmonary injury and its sequelae.
Factors associated with psychological distress in cancer patients
Authors: Cassileth Barrie R. , Lusk Edward J. , Brown Lorraine L , Cross Patricia A. , Walsh William P. , Hurwitz Shelley 
Published: February 2007

AbstractWe studied the mental health of 1,278 patients with cancer and 645 family members of patients with cancer to delineate clinical and demographic characteristics associated with poor psychological status. For both patients and their matched relatives, there was a direct relationship between poorer mental health scores and younger age. Highly significant age differences emerged as well for subscale scores of anxiety, depression, and general positive affect in patients, and for depression, emotional ties, and loss of control in relatives. Treatment status, performance status, and sex also contributed significantly to mental health scores. Patients at greatest risk for psychological problems are young, female, receiving palliative or active treatment as opposed to follow‐up care, and symptomatic or not fully ambulatory. Clinicians should be alert to the potential for psychological problems among patients in these categories.
The staging of childhood acute lymphoblastic leukemia: Strategies of the childrens cancer study group and a three‐dimensional technic of multivariate analysis
Authors: Bleyer W. Archie , Sather Harland , Coccia Peter , Lukens John , Siegel Stuart , Hammond G. Denman 
Published: February 2007

AbstractIn childhood acute lymphoblastic leukemia, univariate analyses have identified more than thirty clinical and laboratory prognostic factors. Multivariate analysis is used to sort out the most independent and predictive of these factors, but the methods used are mathematically and conceptually complex.In this report, we depict the interactions between multiple variables graphically using 3‐dimensional data displays. This approach helps conceptualize the multivariate process and provides an alternative method. We applied the method to the 2,987 children in the CCC‐160 series of studies, and specifically to the “high‐risk” subgroups: initial white cell count (WBC) greater than >50,000/μl; white count > 50,000/μl in conjunction with a mediastinal mass; age at diagnosis less than 1 year; and, central nervous system (CNS) leukemia at diagnosis. Analyzed in this fashion, T‐cell immunophenotype, the presence of a large mediastinal mass, CNS leukemia, and the lymphomatous pattern lose their prognostic value when outcome is stratified by age and WBC. The 3‐dimensional method confirms the mathematical analyses and provides graphic evidence for the conclusions.
Streptococcus bovis bacteremia and underlying gastrointestinal neoplasms
Authors: Friedman Eitan , Elian Dan , Eisenstein Zemach 
Published: February 2007

AbstractTwo patients are described in whom Streptococcus bovis bacteremia was the only clue to the presence of a colonic neoplasm. A third patient had the rare association of gastric carcinoma and Streptococcus bovis bacteremia that followed an operation for the carcinoma. The need for both complete gastrointestinal survey in patients with Streptococcus bovis bacteremia and administration of appropriate antibiotic prophylaxis during surgical manipulation is emphasized.
Hepatocellular carcinoma in thalassemia major
Authors: Borgna‐Pignatti Caterina , De Stefano Piero , Sessa Fausto , Avato Franco 
Published: February 2007

AbstractThe occurrence of hepatocellular carcinoma in a 22‐year‐old man with thalassemia major is reported. As a result of transfusional hemochromatosis, this patient had already developed diabetes, hypogonadism, heart failure, and the sicca syndrome; he was serum and tissue HBsAg negative. Liver iron concentration measured postmortem was found to be 50 times normal.Multiply transfused patients are at risk of developing hepatocellular carcinoma. Serial measurements of serum alpha‐fetoprotein should permit early detection of the tumor and reduce mortality. Preventive measures include early immunisation against hepatitis B virus and prevention of iron accumulation by intensive use of desferrioxamine. Treatment of hemochromatosis‐associated hypogonadism with androgens should be considered with caution.
Extraneural metastases from medulloblastoma: Long‐term survival after sequentially scheduled chemotherapy and radiotherapy
Authors: Mahoney Donald H. , Steuber C. Philip , Sandbach John F. , Fernbach Donald J. 
Published: February 2007

AbstractExtraneural relapse of medulloblastoma is an uncommon event which has typically been associated with a fatal outcome. We present a case of a 2 1/2‐year‐old male who developed extensive bone marrow and bone metastases 19 months after diagnosis and treatment of a medulloblastoma. This patient was successfully treated with a sequentially scheduled combination of vincristine, cyclophosphamide, and doxorubicin and remained free of disease for more than 5 years from the time of relapse.
Squamous cell carcinoma of the thymus: A case report of rapid response to cyclophosphamide, doxorubicin, cisplatin, and prednisone
Authors: Umsawasdi Theera , Chong Clayton , Weedn Victor W. , McKenna Robert J. , Barkley H. Thomas , Chiuten Delia F. 
Published: February 2007

AbstractA woman with unresectable squamous cell carcinoma of the thymus was treated with combination chemotherapy consisting of cyclophosphamide, adriamycin, cisplatin, and prednisone. Rapid tumor response and hyper‐uricemia occurred within 10 days after the first course of chemotherapy. Mediastinal irradiation was given after two courses of chemotherapy. Chemotherapy was continued until the total dose of adriamycin reached 450 mg/m2. The patient is alive and well in remission more than 111 weeks after therapy was begun and more than 63 weeks after treatment was discontinued. Further study of this chemotherapeutic regimen in squamous cell carcinoma of the thymus is needed. Monitoring of serum uric acid levels may be required.
Prolonged echo viral meningitis in a cancer patient with normal serum immunoglobulins
Authors: Watanabe Masayo , Cho Cheng T. , Trueworthy Robert C. , Saving Kay L. 
Published: February 2007

AbstractThis is a report of prolonged meningitis caused by echovirus type 20 in a patient with rhabdomyosarcoma. It represents one of the few documented cases of delayed clearance of echovirus in the cerebrospinal fluid in a patient with normal serum immunoglobulins. The case illustrates the prolonged clinical course of echoviral meningitis in a patient receiving cytotoxic drug therapy, and it suggests that factor(s) other than humoral antibodies may be involved in the elimination of echovirus from the central nervous system.
Radiation myelopathy: A review
Authors: Goldwein Joel W. 
Published: February 2007

AbstractRadiation myelopathy is a serious potential complication associated with radiation therapy to the spinal cord. Its exact cause is unknown. It represents a spectrum of syndromes, the most common of which are acute transient radiation myelopathy and chronic progressive radiation myelitis. A review of the literature indicates that cord damage is related to a number of controllable factors including dose fraction size, treatment time, total dose, length of cord irradiated, technical and clerical errors. Other less well understood factors that appear to contribute to the risk such as combined chemoradiotherapy effects and hyperthermia should also be recognized. A better awareness and understanding of these factors should ultimately lead to safer and more effective treatments.
Radioimmunodetection of neuroblastoma with antineuroblastoma monoclonal antibody
Authors: Etoh Takao , Takahashi Hideyo , Ohnuma Naomi , Maie Masahiko , Tanabe Masahiro , Kuriyama Yutaka 
Published: February 2007

AbstractThe Antineuroblastoma monoclonal antibody CNM‐5 was submitted to preclinical studies and then used for tumor imaging with following results.1. CNM‐5 is an antibody which belongs to the IgM fraction and has a molecular weight of 900 kilodaltons. Its protein concentration was found to be 17.99 mg/dl.2. The 131l‐labeled antibody was injected into nude mice transplanted with human neuroblastoma, and imaging was performed by a gamma camera. Accumulation of 131l in the tumor was relatively clearly seen.Various organs were removed and examined for 131l uptake. Radioactivity was easily detected in the tumor, suggesting that CNM‐5 is effective for use in imaging diagnosis of neuroblastoma.
Metaiodobenzylguanidine (MIBG) labeled with 123I/131I in neuroblastoma diagnosis and follow‐up treatment with a review of the diagnostic results of the international workshop of pediatric oncology held in Rome, september 1986
Authors: Feine U. , Müller‐Schauenburg W. , Treuner J. , Klingebiel T H. 
Published: February 2007

AbstractOur experience in scintigraphic diagnosis using 123l/131l‐metaiodobenzylguanidme (MIBG) on 37 children with neuroblastomas stage III‐IV is reported and discussed, together with the results obtained by other authors on MIBG diagnosis at the International Workshop of Pediatric Oncology held in Rome in September 1986.In our own investigation, 49 examinations were undertaken with 123l‐MIBG and 66 with 131l‐MIBG partly under therapy conditions with high‐activity doses of 131I‐MIBG. There were 29 neuroblastomas, 3 ganglioneuromas, and 3 ganglioneuroblastomas.The localization of all primary tumors was over 90%; for neuroblastomas with a high level of catecholamine excretion, over 95%. The specificity was about 100%.The sensitivity with respect to tumor relapse and all localization of metastasis and bone‐marrow tumor infiltration in the followup‐phase approaches was 70% during or after therapy. What emerges from the experience of most investigators is that 123l‐MIBG is the agent best suited to detect tumor relapse and metastasis, especially in the bone marrow. MIBG examinations are of great value in follow‐up studies for detecting tumor relapse and bone marrow infiltrations, especially before the onset of clinical symptoms and other indications.