bluuebunny/crossref_metadata_2025_split huggingface dataset:
New approach to heart failure: Integrated traditional Chinese with Western medicine
Authors: Wang Qiao , Cao Hongshuai , Li Peizhao , Li Chunyan , Shi Zaixiang , Ren Jingyi 
Published: March 2024

AbstractHeart failure (HF) is a major global healthcare problem leading to substantial deterioration of prognosis. The current clinical guidelines in HF have begun to emphasize the importance of traditional Chinese medicine (TCM). TCM has been utilized in clinical practice for over 2000 years and is capable of treating a variety of HF pathogenic issues. This review summarizes the classification, pathophysiology, and treatment of HF from three perspectives: Western medicine, TCM, and integrated traditional Chinese and Western medicine (ITCWM). Emphasizing the most recent evidence, this review consolidates knowledge on ITCWM treatments for HF pertaining to different TCM syndromes, including TCM decoctions, oral patent Chinese medicine, TCM injections, as well as therapies like acupuncture and moxibustion. Additionally, this review explores TCM approaches to HF prevention, such as tai chi, Baduanjin exercise, and Sanfu acupoint herbal patching. The findings of this study suggest that ITCWM holds promise for the treatment and rehabilitation of HF. However, further research is warranted to elucidate the underlying mechanisms.
2020 feels slow, long, and far away: Time distortion due to the COVID‐19 pandemic
Authors: Castellà Judit , Ueno Taiji , Allen Richard J. 
Published: March 2024

AbstractThe COVID pandemic has been an unforeseen situation in which uncertainty, social distance, loss of stability, and significant changes have proven to have detrimental effects on people's well‐being and on mental health. The aim of the present study is to determine changes in subjective time speed, duration, and time distance, and to consider the factors that may have contributed to this subjective distortion. A questionnaire was designed to explore time perception along with autobiographical recollection, mental and physical activity, and mood before, during, and after the pandemic. Analysis revealed that the pandemic period differed from before and after on every scale; subjects reported relatively lower values on autobiographical memory for the pandemic period; felt this time period to be further away, slower, and longer; were less active; and had a more negative mood. A structural equation model revealed that mood was the main predictor of subjective time distortion.
Synergistic Osteogenic and Antiapoptotic Framework Nucleic Acid Complexes Prevent Diabetic Osteoporosis
Authors: Bai Long , Feng Maogeng , Zhang Qiuwen , Cai Zhengwen , Li Qiumei , Li Yong , Ma Chuan , Xiao Jingang , Lin Yunfeng 
Published: March 2024

AbstractDiabetes mellitus (DM) is characterized by elevated blood glucose and advanced glycation end product (AGEs) levels. Increased AGEs in bone tissue inhibit osteogenic differentiation by bone marrow mesenchymal stem cells (BMSCs), leading to bone loss and osteoporosis in diabetic patients. Enhancing the osteogenic differentiation capacity of BMSCs in the presence of abundant AGEs can improve bone health and prevent osteoporosis in DM patients. The flavonoid, Quercetin, has anti‐inflammatory, antibacterial, and antitumor properties; however, it is insoluble in water and thus not easily absorbed by the body. Nanodrug delivery systems such as tetrahedral framework nucleic acids (tFNAs) exhibit excellent biocompatibility, efficient cell uptake, and drug piggybacking. In the present study, tFNAs with quercetin is complexed to form a novel nanodrug (tFNAs/Que) that combined the features of both components. tFNAs/Que promote osteogenic differentiation by BMSCs in an in vitro AGEs‐rich environment, maintain bone mass, and prevent diabetic osteoporosis in DM mice in vivo. The mechanism of tFNAs/Que against AGEs may be related to the JNK signaling pathway. In conclusion, it is shown that tFNAs/Que has a dual regulatory role by promoting osteogenic differentiation and inhibiting apoptosis. Such a feature is promising for the prevention and treatment of diabetic osteoporosis.
Reconfigurable Sensing‐Memory‐Processing and Logical Integration Within 2D Ferroelectric Optoelectronic Transistor for CMOS‐Compatible Bionic Vision
Authors: Wang Yang , Zhou Ting , Cui Yi , Xu Minyi , Zhang Miao , Tang Kai , Chen Xinrui , Tian Haoxiang , Yin Chujun , Huang Jianwen , Yan Chaoyi , Wang Xianfu 
Published: March 2024

AbstractNeuromorphic ferroelectric transistors integrating sensing and memory capabilities for photoelectric stimuli have provided a remarkable platform for multifunctional bionic vision. However, most hardware demonstrations utilizing ferroelectric transistors cannot implement multiple bio‐visual functions simultaneously under a small operating voltage with scalable material systems, which reduces the compatibility with complementary metal‐oxide‐semiconductor (CMOS) technology and blocks further bio‐visual applications. Herein, an optoelectronic transistor gated is constructed with ferroelectric LiNbO3, which exhibits sensing‐memory‐processing functions and logic integration simultaneously under a low operating voltage (≈1.5 V). Benefiting from the programmable photoinduction and strong ferroelectric polarization, the reliable and highly controllable synaptic characteristics and the bio‐visual selective learning behavior are successfully demonstrated. A high recognition accuracy (≈94.5%) in simulations is also achieved due to the unique linear synaptic plasticity. Furthermore, based on dual‐wavelength modulation, the full‐optical logics “AND” and “OR” are established within the same device. This work provides novel opportunities for the complex multifunctional bionic vision and toward large‐scale integration compatible with silicon‐based CMOS processes.
Patterning of Hybrid Metal Halide Perovskite via Printed Molecular Templates
Authors: Kessel Amit , Moon Josh , Benitez‐Rodriguez Juan F , Deng Hao , Mao Wenxin , Alan Tuncay , Bach Udo , Jasieniak Jacek 
Published: March 2024

AbstractPatterning metal halide perovskite thin films is a necessary pathway to expand their optoelectronic applications. However, developing a suitable patterning technique is challenging as conventional lithographic processes are either detrimental to the perovskite layer or lack compatibility with scalable fabrication processes used in the manufacturing of printed electronics. In this work, a complete bottom‐up patterning method is proposed based on de‐wetting from a hydrophobic molecular template, which constrains the perovskite ink to directly crystallize in selected hydrophilic regions. Octadecylphosphonic acid molecules are used as the hydrophobic template and are effectively transferred onto metal‐oxide substrates via micro‐contact printing. This allows for a low‐cost, rapid, and scalable micron‐scale patterning of perovskite thin films. Facile control over light transmittance is demonstrated by adjusting the amount of exposed area and the corresponding spectral shape changes shift the film's appearance toward being color‐neutral. Finally, the method's scalability and versatility are shown by fabricating 25 cm2 patterned films over rigid and flexible substrates.
High‐Efficiency Flexible Cs2AgBiBr6‐Based Visible Photodetector with Transferable TiO2 Nanorod Electron‐Transport Layer
Authors: Jeong Seongmin , Ha Juyun , Li Xin , Jung Uijin , Kim Sangmin , Park Jinsub 
Published: March 2024

AbstractIn this work, a flexible perovskite photodetector is demonstrated with a transferable TiO2 nanorod (NR) as an electron transport layer (ETL). The TiO2 NRs are grown by the hydrothermal method on Ni metal buffer layer/Si (100) substrates. During the growth process of TiO2 NRs in solution, the Ni sacrificial buffer layer is removed by hydrochloric acid in the initial stage. The resulting suspended seed layer can then sustain the growth of TiO2 NRs in both the top and bottom directions. The successfully grown TiO2 NRs are now transferred onto an ITO‐coated PET substrate as an ETL for the flexible Cs2AgBiBr6 perovskite photodetectors. The fabricated photodetector operates under a wavelength of 405 nm, and at an external bias voltage of −0.3 V, it exhibits an outstanding performance with an on/off ratio of 1.23 × 104, photoresponsivity (R) of 0.666 A W−1, and a detectivity (D*) of 9.29 × 1012 Jones. In terms of flexibility, the optoelectronic performance of each device is well kept within 5% after 300 bending test cycles with a radius of 1 cm. The suggested transferable TiO2 NRs can improve the efficiency of flexible optoelectronic devices that require synergistic electron transfer effects by using heterostructures with TiO2 nanostructures.
Mobility and Fate of Potentially Toxic Elements in Soil Environment
Authors: Duan Jingtao , Biswal Basanta Kumar , Balasubramanian Rajasekhar 
Published: March 2024

AbstractSoil pollution, caused by potentially toxic elements (PTEs), is a significant problem worldwide. This study has investigated the key factors that control the mobility and fate of six PTEs (Pb, Cd, Cr, Cu, Zn, and Ni) which are frequently detected in contaminated soils. The findings of this study demonstrate that smaller particles present in soil show stronger adsorption capacity compared to larger particles because of the higher specific surface area. Moreover, soil with higher organic matter content (e.g., humic acid) exhibits stronger adsorption capacity due to the presence of abundant functional groups namely hydroxyl (─OH) and carboxyl (─COOH). Notably, these functional groups possess high affinity for Pb adsorption, followed by Cd > Cu > Cr > Zn > Ni. The adsorption of most of the PTEs by soil with and without humic acid is better described by the Langmuir isotherm model and pseudo‐second‐order kinetic model. Overall, the experimental results illustrate that soil with high contents of humic acid can restrict the mobility of PTEs. This mechanistic evaluation predicts how soils with different organic matter contents respond to PTEs pollution. This study outcome will be helpful in developing sustainable remediation strategies to tackle pollution caused by PTEs in the soil environment.
Fluorescent Solvatochromic Probes for Long‐Term Imaging of Lipid Order in Living Cells
Authors: Tanaka Takuya , Matsumoto Atsushi , Klymchenko Andery S. , Tsurumaki Eiji , Ikenouchi Junichi , Konishi Gen‐ichi 
Published: March 2024

AbstractHigh‐resolution spatio‐temporal monitoring of the cell membrane lipid order provides visual insights into the complex and sophisticated systems that control cellular physiological functions. Solvatochromic fluorescent probes are highly promising noninvasive visualization tools for identifying the ordering of the microenvironment of plasma membrane microdomains. However, conventional probes, although capable of structural analysis, lack the necessary long‐term photostability required for live imaging at the cellular level. Here, an ultra‐high‐light‐resistant solvatochromic fluorescence probe, 2‐N,N‐diethylamino‐7‐(4‐methoxycarbonylphenyl)‐9,9‐dimethylfluorene (FπCM) is reported, which enables live lipid order imaging of cell division. This probe and its derivatives exhibit sufficient fluorescence wavelengths, brightness, polarity responsiveness, low phototoxicity, and remarkable photostability under physiological conditions compared to conventional solvatochromic probes. Therefore, these probes have the potential to overcome the limitations of fluorescence microscopy, particularly those associated with photobleaching. FπCM probes can serve as valuable tools for elucidating mechanisms of cellular processes at the bio‐membrane level.
Design and Synthesis of Transferrable Macro‐Sized Continuous Free‐Standing Metal‐Organic Framework Films for Biosensor Device
Authors: Zhao Zhe , Ke Xinyi , Huang Jiayuan , Zhang Ziyu , Wu Yue , Huang Gaoshan , Tan Ji , Liu Xuanyong , Mei Yongfeng , Chu Junhao 
Published: March 2024

AbstractMetal organic framework (MOF) films have attracted abundant attention due to their unique characters compared with MOF particles. But the high‐temperature reaction and solvent corrosion limit the preparation of MOF films on fragile substrates, hindering further applications. Fabricating macro‐sized continuous free‐standing MOF films and transferring them onto fragile substrates are a promising alternative but still challenging. Here, a universal strategy to prepare transferrable macro‐sized continuous free‐standing MOF films with the assistance of oxide nanomembranes prepared by atomic layer deposition and studied the growth mechanism is developed. The oxide nanomembranes serve not only as reactant, but also as interfacial layer to maintain the integrality of the free‐standing structure as the stacked MOF particles are supported by the oxide nanomembrane. The centimeter‐scale free‐standing MOF films can be transferred onto fragile substrates, and all in one device for glucose sensing is assembled. Due to the strong adsorption toward glucose molecules, the obtained devices exhibit outstanding performance in terms of high sensitivity, low limit of detection, and long durability. This work opens a new window toward the preparation of MOF films and MOF film‐based biosensor chip for advantageous applications in post‐Moore law period.
Optimizing nitrogen application rates for winter canola in Mississippi
Authors: Gajula Praveen , Singh Gurbir , Kaur Gurpreet , Dhillon Jagmandeep 
Published: March 2024

AbstractThe production of canola (Brassica napus L.) in the United States is low, whereas the demand is high. Most US canola research is centered in the Midwest, with minimal to no research in Southern states including Mississippi. Therefore, a study was conducted in Mississippi to assess the feasibility of canola as a double crop with soybean (Glycine max L.) rotation and determine its optimum nitrogen (N) requirement. After canola was harvested, soybean was planted within the same experimental plots. In total, six N treatments (0 [control], 34, 67, 101, 135, and 168 kg N ha−1) were applied to canola and replicated four times across all site‐years in a randomized complete block design. The application of N increased seed yield, aboveground biomass, and N content compared to the control in canola. Across all site‐years, the highest seed yield was 1726 kg ha−1 at 168 kg N ha−1. Moreover, N uptake, plant height, and test weight were highest at 135 kg N ha−1, which were 76%, 21%, and 44% greater than control, respectively. Oil content and seed weight were inversely related to N rates indicating dilution with increased N. Overall, 141 kg N ha−1 was found to be the agronomic optimum nitrogen rate, and no further supplementation was deemed necessary to maximize canola yield in Mississippi. Additionally, the following soybean crop benefitted from the N applied to canola and produced greater yields. This study establishes that canola has the potential for double cropping without adversely affecting subsequent soybean yield, provided optimum N rates are applied.
Novel drag and Nusselt number models based on direct numerical simulations of a bidisperse gas–solid system
Authors: Wang Dong , Wang Shuai , Jin Tai , Luo Kun , Fan Jianren 
Published: March 2024

AbstractFlow and heat transfer in a bidisperse gas–solid system with freely moving spheres are simulated by particle‐resolved direct numerical simulation (PR‐DNS). Gas–solid coupling is enforced by the direct‐forcing immersed boundary method. Compard with the DNS database, it is found that the existing polydisperse drag correction model developed from static systems combined with various monodisperse drag models underestimates the drag force on dynamic arrays of particles. The existing Nusselt number correction model developed from static systems combined with various monodisperse models overestimates the Nusselt number of dynamic arrays of particles. Sensitivity analysis indicates that the effects of the granular temperature on the drag force and Nusselt number are negligible. Novel polydisperse drag and Nusselt number models are derived based on the database. The advantages of the derived polydisperse drag and Nusselt number models are demonstrated and confirmed by comparing the results of the computational fluid dynamics–discrete element method using various drag and Nusselt number models with experimental or additional PR‐DNS data.
Kinetics and mechanistic insights into selective hydrogenation of furfural to furfuryl alcohol over Ni–Ga intermetallics
Authors: Sun Weixiao , Ge Xiaohu , Du Wei , Zeng Jianrong , Ma Jianbo , Chen Wenyao , Qian Gang , Cao Yueqiang , Duan Xuezhi , Zhou Xinggui , Zhang Jing 
Published: March 2024

AbstractFurfural was mainly used to produce furfuryl alcohol, which is a monomer of furan resins with a global market of ~$0.3 billion/year. Industrial production of furfuryl alcohol is via selective hydrogenation over toxic copper chromate under harsh conditions. Therefore, the search for active and non‐toxic alternatives is highly desired. Here, kinetics studies revealed an inhibitive effect caused by strong furfural adsorption on Ni‐based catalysts, resulting in sites blocking and undesired ring hydrogenation. Such an inhibitive effect can be alleviated over Ni‐Ga intermetallic surfaces by tuning the Ni coordination number, from which the Ni1Ga1 showed markedly enhanced furfuryl alcohol yield (~99%) at milder conditions comparing to the referred Ni catalyst. It is found that isolated Ni sites by Ga on the Ni1Ga1 enabled a tilted adsorption configuration through the carbonyl of furfural. In contrast, the stronger flat‐lying adsorption of furfural was favored on the contiguous Ni sites of the referred catalyst.
Neopolyploidy‐induced changes in giant duckweed (Spirodela polyrhiza) alter herbivore preference and performance and plant population performance
Authors: Assour Hannah R. , Ashman Tia‐Lynn , Turcotte Martin M. 
Published: March 2024

AbstractPremisePolyploidy is a widespread mutational process in angiosperms that may alter population performance of not only plants but also their interacting species. Yet, knowledge of whether polyploidy affects plant–herbivore dynamics is scarce. Here, we tested whether aphid herbivores exhibit preference for diploid or neopolyploid plants, whether polyploidy impacts plant and herbivore performance, and whether these interactions depend on the plant genetic background.MethodsUsing independently synthesized neotetraploid strains paired with their diploid progenitors of greater duckweed (Spirodela polyrhiza), we evaluated the effect of neopolyploidy on duckweed's interaction with the water‐lily aphid (Rhopalosiphum nymphaeae). Using paired‐choice experiments, we evaluated feeding preference of the herbivore. We then evaluated the consequences of polyploidy on aphid and plant performance by measuring population growth over multiple generations.ResultsAphids preferred neopolyploids when plants were provided at equal abundances but not at equal surface areas, suggesting the role of plant population surface area in driving this preference. Additionally, neopolyploidy increased aphid population performance, but this result was dependent on the plant's genetic lineage. Lastly, the impact of herbivory on neopolyploid vs. diploid duckweed varied greatly with genetic lineage, where neopolyploids appeared to be variably tolerant compared to diploids, sometimes mirroring the effect on herbivore performance.ConclusionsBy experimentally testing the impacts of polyploidy on trophic species interactions, we showed that polyploidization can impact the preference and performance of herbivores on their plant hosts. These results have significant implications for the establishment and persistence of plants and herbivores in the face of plant polyploidy.
Comparison of waist circumference and waist‐to‐height ratio as predictors of clustering of cardiovascular risk factors among middle‐aged people in rural Khanh Hoa, Vietnam
Authors: Shrestha Rachana Manandhar , Pham Thuy Thi Phuong , Yamamoto Shohei , Nguyen Chau Que , Fukunaga Ami , Danh Phan Cong , Hachiya Masahiko , Le Huy Xuan , Do Hung Thai , Mizoue Tetsuya , Inoue Yosuke 
Published: March 2024

AbstractObjectiveGiven the population‐level variation in stature, a universal cut‐off for waist circumference (WC) may not be appropriate for some populations. We compared the performance of WC and waist‐to‐height ratio (WHtR) to detect the clustering of cardiovascular disease (CVD) risk factors in rural Vietnam.MethodsWe obtained data from a baseline survey of the Khanh Hoa Cardiovascular Study comprising 2942 middle‐aged residents (40–60 years). We used areas under the receiver operating characteristics curve (AUROC), net reclassification index (NRI), and integrated discrimination improvement (IDI) to compare the performance of WC and WHtR in predicting CVD risk clustering (≥2 of the following risk factors: hypertension, diabetes, dyslipidemia, and elevated C‐reactive protein).ResultsThe optimal cut‐off values for WC were 81.8 and 80.7 cm for men and women, respectively. Regarding the clustering of CVD risk factors, the AUROC (95% CI) of WC and WHtR were 0.707 (0.676 to 0.739) and 0.719 (0.689 to 0.749) in men, and 0.682 (0.654 to 0.709) and 0.690 (0.663 to 0.717) in women, respectively. Compared with WC, WHtR had a better NRI (0.229; 0.102–0.344) and IDI (0.012; 0.004–0.020) in men and a better NRI (0.154; 0.050–0.257) in women.ConclusionsThe optimal WC cut‐off for Vietnamese men was approximately 10 cm below the recommended Asian cut‐off. WHtR might perform slightly better in predicting the clustering of CVD risk factors among the rural population in Vietnam.
Losing lemurs: Declining populations and land cover changes over space and time
Authors: Narváez‐Torres Pamela R. , Guthrie Nicola K. , Brichieri‐Colombi Typhenn A. , Razafindravelo Cressant P. , Jacobson Zachary S. , Tera Fredo , Rafidimanana Daniel V. , Rahasivelo Zé‐Elinah , Petersen Melody A. , Ramangason Hasinala , Randall Lea , McPherson Jana M. , Frasier Cynthia L. , Moehrenschlager Axel , Holmes Sheila M. , Louis Edward E. , Johnson Steig E. 
Published: March 2024

AbstractForest loss and degradation due to land cover changes imperil biodiversity worldwide. Subtropical and tropical ecosystems experience high deforestation rates, negatively affecting species like primates. Madagascar's endemic lemurs face exceptionally high risks of population declines and extirpation. We examined how short‐term land cover changes within a fragmented landscape in southeastern Madagascar impacted the density of lemur species. Using line transects, we assessed density changes in nine lemur species across five forest fragments. Diurnal surveys were conducted monthly from 2015 to 2019 on 35 transects (total effort = 1268 km). Additionally, 21 transects were surveyed nocturnally in 2015 and 2016 (total effort = 107.5 km). To quantify forest cover changes, we generated land use/land cover (LULC) maps from Sentinel‐2 imagery using supervised classification for each year. For the LULC maps, we overlayed species‐specific buffers around all transects and calculated the proportion of land cover classes within them. We observed declines in the annual densities of four diurnal and cathemeral lemur species between 2015 and 2019, with species‐specific declines of up to 80% (Varecia variegata). While the density of two nocturnal species decreased, one increased fivefold (Cheirogaleus major) between 2015 and 2016. By 2019, Grassland was the dominant land type (50%), while Paddy Fields had the smallest coverage (1.03%). Mature Agricultural Land increased the most (63.37%), while New Agricultural Land decreased the most (–66.36%). Unexpectedly, we did not find evidence that higher forest cover supported a higher lemur population density within sampled areas, but we found support for the negative impact of degraded land cover types on three lemur species. Our study underscores the urgent need to address land‐use changes and their repercussions for primate populations in tropical ecosystems. The diverse responses of lemur species to modified habitats highlight the complexity of these impacts and emphasize the importance of targeted conservation efforts.