bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bacteriological studies of cardiac tissues obtained at autopsy from eleven patients dying with rheumatic fever
Authors: Watson Robert F. , Hirst George K. , Lancefield Rebecca C. 
Published: February 2007

AbstractBacteriological studies of cardiac tissues obtained at autopsy were made on eleven patients dying with rheumatic fever. Thirty‐four of 44 valves cultured showed evidence of active rheumatic valvulitis. Group A hemolytic streptococci were isolated from only two of these affected valves. The results of this study do not support the view that rheumatic valvulitis is due to direct invasion of the valves by group A hemolytic streptococci.
Studies of Alcaptonuria: A Genetic Study of 58 Cases Occurring in Eight Generations of Seven Inter‐related Dominican Kindreds
Authors: Milch Robert Austin 
Published: February 2007

AbstractA study of the inheritance patterns of the molecular disease alcaptonuria has been conducted in the Dominican Republic. A total of 58 authenticated cases have been observed to date, and additional cases undoubtedly exist. Viewed collectively, all of the observed data, including instances of apparent, though spurious, dominant transmission, appear to be adequately explicable on the assumption that the alcaptonuria allele behaves in these kindreds as if it were a simple, rare autosomal recessive.
A gallery of gout being a miscellany of prints and caricatures from the 16th century to the present day
Authors: Rodnan Gerald P. 
Published: February 2007

AbstractThe prominence of the gout in the annals of medical art and pictorial satire may be looked upon as an interesting by‐product of the centuries old association of the disease with overindulgence in food and drink, in venery, and the „like exhausting passions”︁ of a life of unregulated, oft ill‐gotten luxury.
The role of antinuclear reactions in the diagnosis of systemic lupus erythematosus: A study of 53 cases
Authors: Rothfield Naomi F. , Phythyon James M. , McEwen Currier , Miescher Peter 
Published: February 2007

AbstractFifty‐three patients with symptoms suggestive of S.L.E. were studied clinically and serologically (antinuclear reactions included complement fixation against nucleoprotein, DNA, and histone, tests for rheumatoid arthritis). Clinically and serologically, the patients with (72 per cent) and without (18 per cent) L.E. cell phenomenon did not differ significantly and seem to represent one nosological entity. It is suggested that in the past too much emphasis has been placed on a positive L.E. cell test in establishing the diagnosis of S.L.E. The results clearly indicate that in addition to this test, antinuclear reactions are an indispensable tool in establishing the diagnosis of S.L.E.
Studies of alcaptonuria: Adsorption of homogentisic acid solutions on collagen chromatographic columns
Authors: Milch Robert Austin , Murray Richard A. 
Published: February 2007

AbstractMonomeric and polymeric homogentisic acid solutions were passed through chromomatographic columns of isoelectric and n‐acetylated hide powder collagen. There was no evidence of binding of the unoxidized monomer to the collagen. Autoxidized polymeric homogentisic acid solutions (HGA‐OP), however, were strongly adsorbed. The data are interpreted to indicate that HGA‐OP is a potent tanning agent for hide powder collagen.
Musculoskeletal complaints in an industry annual complaint rate and diagnosis, absenteeism and economic loss
Authors: Brown Robert , Lingg Claire 
Published: February 2007

AbstractAn industry, with a diversity of occupations and many different types of working conditions, was surveyed for the incidence of rheumatic complaints among its employees. The incidence and site of complaint, as well as the varieties of musculoskeletal disorders, were correlated with age, sex and type of work. Estimates were made of the economic loss to the company owing to rheumatic complaints in terms of absenteeism and medical services required.
Studies of relatives of patients with systemic lupus erythematosus
Authors: Morteo O. Garcia , Franklin E. C. , McEwen Currier , Phythyon James , Tanner Martin 
Published: February 2007

AbstractA study of 44 relatives of 19 patients with systemic lupus erythematosus showed that 11 per cent had clinical evidence of a collagen disease. The sera of one third of the asymptomatic relatives contained rheumatoid factor, while the incidence of hypergammaglobulinemia, biologic false positive tests for syphilis and antinuclear antibodies was lower but significantly greater than in the control population. Three quarters of the patients had at least one relative with clinical and/or laboratory abnormalities.
The Latex fixation test in the spinal fluid and urine of patients with rheumatoid arthritis
Authors: Starnes Willard R. , Ulloa Alexander , Holley Howard L. 
Published: February 2007

AbstractThe finding of an abnormal macroglobulin in the serum of patients with rheumatoid arthritis has been isolated and characterized by several groups of investigators. A study was undertaken to study other biological fluids as to the presence of this abnormal globulin. Spinal fluids and urines were obtained from patients with arthritis. The patients were divided into three groups: (1) ankylosing spondylitis; (2) osteoarthritis; and (3) rheumatoid arthritis, active, untreated. The serum of patients with rheumatoid arthritis gave positive latex fixation test. Latex fixation test on the spinal fluids from the three groups gave a negative latex agglutination. The urines and spinal fluids were concentrated to a known volume with polyvinyl pyrrolidone (P.V.P.). There was found an increase in the total protein bound hexoses in the three latex positive urine concentrates.
Effect of heat on the rheumatoid factor precipitation reaction with human Gamma‐Globulin
Authors: Epstein Wallace V. , Ross Margaret 
Published: February 2007

AbstractTo determine the heat lability of rheumatoid factor, rheumatoid serum was heated to 56° C. for 30 minutes. This amount of heat reduced precipitating ability and caused a concurrent loss of hemagglutinating activity in the supernatant, as measured by the F II hemagglutination system.
Osteolytic vertebral lesions as a manifestation of rheumatoid arthritis and related disorders
Authors: Lorber Arthur , Pearson Carl M. , Rene Robert M. 
Published: February 2007

AbstractThree patients, whose presenting clinical complaints were back pain, had rheumatoid arthritis or ankylosing spondylitis. Destructive vertebral lesions were present in each case and biopsy specimens from the spine in two patients revealed rheumatoid nodules in one and chronic inflammation and invasive fibrosis in the second. Vertebral and disc lesions are rare in rheumatoid arthritis and relatively common in spondylitis. In the latter disease the lesion may be mistaken for a tuberculous abscess.
The Behavior of rheumatoid marrow in culture
Authors: Jeffrey Maurice R. 
Published: February 2007

AbstractHemopoietic marrow from patients with rheumatoid arthritis and controls was cultured in various substrate sera. The normal and some rheumatoid marrows were sensitive to the different iron concentrations of normal and rheumatoid sera. In rheumatoid patients with hypochromic anemia, the response of marrow to added iron in vitro agreed with the therapeutic response to intravenous iron. Patients with refractory normochromic anemia showed slightly abnormal erythropoiesis, but there was no evidence that their serum differed from that of non‐anemic patients. By this technic, evidence for stimulation of marrow by batyl alcohol or other agents was equivocal.
The protein and carbohydrate‐protein complexes of synovial fluids
Authors: Blair Mary Grace , Pigman Ward , Holley Howard L. 
Published: February 2007

AbstractDialysis of normal and arthritic human synovial fluids at low ionic strength produced precipitates resembling the euglobulins of blood but often containing hyaluronic acid. Their compositions demonstrated the ability of hyaluronic acid to form insoluble complexes with globulins between pH 5.5 and 6.4, and with albumin at pH 5.5 when the concentration of globulins was low. Hyaluronic acid precipitated quantitatively at pH 4.4, but the percentage of hyaluronic acid increased with diminishing amounts of total precipitate between pH 4.4 and 2.6.
High dosage steroid therapy for systemic lupus erythematosus
Authors: Dubois Edmund L. 
Published: February 2007

AbstractThe amount of corticosteroid required for the treatment of systemic lupus erythematosus varies with the severity of the illness. Four cases of lupus crisis are presented demonstrating the probable life‐saving effectiveness of massive dosages in three of them. One required 2300 mg. daily of cortisone for five days and another 2100 mg. daily for fifteen days to control exacerbations associated with central nervous system involvement. Following such treatment remissions as long as eight years occurred.
Tietze's syndrome: Report of two cases and review of the literature
Authors: Levey Gerald S. , Calabro John J. 
Published: February 2007

AbstractTietze's syndrome, a nonsuppurative, tender swelling of the anterior chest wall, is a disorder of uncertain etiology and pathology, unassociated with constitutional disturbances, and of a prolonged fluctuating course. Familiarity with the uniform clinical manifestations of this relatively frequent entity makes its recognition fairly simple. The therapeutic approach includes reassurance of the patient as to the benign nature of this condition, along with supportive measures chiefly to allay pain.
Studies on the Gm factors: Comparison of the agglutinators in serum from patients with rheumatoid arthritis and in serum from healthy donors
Authors: Steinberg Arthur G. 
Published: February 2007

AbstractTitration and absorption studies of the agglutinators used to detect genetically determined human γ‐globulin groups showed that (a) the agglutinators in rheumatoid arthritis serum and in normal serum are probably the same, (b) the inhibition of R.A. sera by Gm (−) serum is due to a non‐specific reaction, and (c) R.A. sera have at least two kinds of β2M molecules, those with rheumatoid factor activity and those with both rheumatoid and gamma group activity.
Chronic arthritis with splenomegaly and leukopenia
Authors: Denko Charles W. , Zumpft Charles W. 
Published: February 2007

AbstractCurrently, the adult patient with chronic arthritis, leukopenia, and splenomegaly is classified as having a variant of rheumatoid arthritis or systemic lupus erythematosus, or is regarded as having a distinct clinical entity known as Felty's syndrome. Twenty‐four such patients were studied with clinical, pathologic and laboratory features to substantiate our hypothesis that these persons have two diseases, one to explain the polyarthritis, and another to explain the hypersplenism. The features of rheumatoid arthritis were present in eighteen patients, while osteoarthritis occurred in five, and gout was found in one. Evaluation of the histopathologic changes in the spleens removed in treatment indicated that most patients had the fibrosis characteristic of systemic lupus erythematosus, while the others had various splenic disorders such as Hodgkin's disease and leukemia.
Lupus erythematosus and avascular bone necrosis: A clinical study of three cases and review of the literature
Authors: Siemsen Jan K. , Brook Jack , Meister Lester 
Published: February 2007

AbstractAvascular necrosis of the femoral head was observed in two patients with systemic lupus erythematosus and one patient with facial discoid lupus erythematosus and equivocal evidence of dissemination. Histologic studies in one case suggested widespread vasculitis. One of the patients had never received corticosteroid treatment. Therefore, it seems somewhat more likely that the avascular necrosis is due to lupus erythematosus than to steroid‐induced vasculitis.
The autoradiographic localization and distribution of neutron activated gold (Au198) in skeletal tissues and synovia of mice
Authors: Tonna Edgar A. , Brecher George , Cronkite Eugene P. , Schwartz Irving L. 
Published: February 2007

AbstractThe localization and distribution of neutron activated radioactive gold in the long bones and knee joints of mice was determined autoradiographically following treatment of animals with gold thioglucose and thiomalate. Gold was found 1 or 2 months later at the surface of the synovium, the osteogenic layer of the perichondrial periosteum, reticuloendothelial cells of the marrow and osteogenic cells along the surface of the metaphyseal trabeculae and secondary centers of ossification. Gold was not seen in cartilage.
Immunologic studies of the proteins of human synovial fluid
Authors: Schur Peter H. , Sandson John 
Published: February 2007

AbstractSynovial fluid and serum were compared by immunoelectrophoresis. The quantity of the large molecular weight proteins (beta 2 macroglobulin, beta lipoprotein, alpha 2 macroglobulin) was markedly reduced in normal synovial fluid. Small molecular weight proteins were present in all synovial fluids. Using an antiserum to synovial fluid, a protein (beta 2F) was detected in inflammatory synovial fluids. This protein appears to be a degradation product of fibrinogen, and was not present in either normal synovial fluid or serum.
Studies in latex agglutination: An approach to the determination of optimum conditions for discrimination between rheumatoids and normals
Authors: Brooks George W. , Cobb Sidney 
Published: February 2007

AbstractOptimum conditions for latex agglutination by rheumatoid factors have been investigated with respect to pH, ionic strength, gamma globulin concentration and heat of inactivation. A large number of sero‐negative cases of rheumatoid arthritis was studied. Best discrimination between rheumatoids and normals was found at pH 8.4 instead of at pH 8.2, with 0.6 per cent instead of 1.0 per cent sodium chloride, without gamma globulin and without heat except for 15 minutes inactivation at 56 C.
A double‐blind comparison of the anti‐rheumatic properties of amopyroquin‐HCl (Propoquin) and chloroquine‐diphosphate
Authors: Lansbury John , Menduke Hyman 
Published: February 2007

AbstractPropoquin and chloroquine were given in equal doses to 25 rheumatoid patients for 3 to 5 months. No clinically or statistically significant difference between the two drugs was detected. Both appeared to have an anti‐rheumatic effect. No serious toxicity was encountered. Neither disease of long duration nor concomitant corticosteroid administration appeared to influence the responses.
Localization of “fibrinoid” deposit in lupus nephritis: An electron microscopic demonstration of glomerular endothelial cell phagocytosis
Authors: Browne John T. , Hutt Martin P. , Reger James F. , Smith Stuart W. 
Published: February 2007

AbstractRenal biopsies from two patients with active lupus nephritis showed Feulgenpositive “fibrinoid” forming glomerular capillary “wire loops.” Electron microscopy demonstrated this material on the endothelial side of basement membrane, within endothelial cell vesicles, and in the capillary lumen. This localization suggests that “wire loop” pathogenesis involves formation in the glomerular capillary lumen of a complex DNA‐containing precipitate which undergoes endothelial cell phagocytosis and deposition on the subendothelial side of the basement membrane.
Separation of rheumatoid factors of different specificities using columns conjugated with gamma‐globulin
Authors: Williams Ralph C. , Kunkel Henry G. 
Published: February 2007

AbstractPolyaminostyrene columns diazotized to human Fr II, aggregated human Fr II, and rabbit γ‐globulin, were used to separate rheumatoid factors of three general types. One group showed primary specificity for human γ‐globulin; the second, for rabbit γ‐globulin; and the third showed reactivity with both rabbit and human γ‐globulin systems.
Rheumatoid arthritis with serologic evidence suggesting systemic lupus erythematosus: Clinical, serologic and chromatographic studies
Authors: Willkens Robert F. , Decker John L. 
Published: February 2007

AbstractFourteen patients with antinuclear activity demonstrable in their serum were studied in detail. All had severe, deforming rheumatoid arthritis with visceral manifestations, and eight had chronic leg ulcers. Serum protein chromatography provided evidence that, in these patients, macromolecular globulins comprised a greater proportion of the antinuclear activity than was true in systemic lupus erythematosus. The factors were considered to be a manifestation of rheumatoid arthritis possibly provoked by chronic bacterial infection.
The occurrence of the mucocutaneous lesions of reiter's syndrome (“keratosis blennorrhagica”) in a patient with classical rheumatoid arthritis
Authors: Shalit Ivan E. , Wilske Kenneth R. , Decker John L. , Ford Denys K. , Lever Walter F. , Ragan Charles 
Published: February 2007

AbstractA case developing manifestations of Reiter's syndrome eight years after the onset of classical rheumatoid arthritis is reported. Clinical and histological study revealed features of both diseases. The uniqueness of this combination emphasizes that Reiter's syndrome is not a variant of rheumatoid arthritis and, indeed, suggests that the two tend to be mutually exclusive.
Effect of chloroquine on the sulfhydryl group and the denaturation of bovine serum albumin
Authors: Gerber Donald A. 
Published: February 2007

AbstractChloroquine diphosphate was demonstrated to be capable of blocking the sulfhydryl disulfide interchange reaction that ordinarily occurs during the denaturation of bovine serum albumin by either heat or urea. Chloroquine was also shown to inhibit the reduction of ferricyanide by cysteine, and to bind to certain sulfhydryl groups of human serum protein when present in concentrations found in patients taking the compound for rheumatoid arthritis.
Excretion of tryptophan metabolites by patients with rheumatoid arthritis
Authors: Flinn John H. , Price J. M. , Yess Norma , Brown R. R. 
Published: February 2007

AbstractThe urinary excretion of tryptophan metabolites was measured in control subjects, in patients with active rheumatoid arthritis, and in patients with related disorders. After tryptophan loading, 12/15 female patients and 4/5 male patients with active rheumatoid arthritis and a positive latex test had significantly elevated levels of one or more of the tryptophan metabolites measured. Hydroxykynurenine and kynurenine were the metabolites most frequently elevated. Although excretion of 4‐pyridoxic acid was in the normal range in these subjects, administration of supplements of pyridoxine restored tryptophan metabolism toward normal in a group of 11 female patients in which this was studied. The data suggests that a high percentage of these patients have a functional pyridoxine deficiency demonstrable in tryptophan metabolism only by means of a tryptophan loading test.
The costovertebral joints. Anatomical‐clinical observations in arthritis
Authors: Nathan H. , Weinberg H. , Robin G. C. , Aviad I. 
Published: February 2007

AbstractCostovertebral arthritis was found to be a frequent condition in a study of 346 skeletons and 100 roentgenograms. It followed a definite pattern of distribution, which seems to be related to the anatomical characteristics of the joints and the ribs involved at the different thoracic levels. No differences were found between the races and sexes. In a few patients in which the diagnosis of costovertebral arthritis was established, local treatment was tried with good results.
Calcinosis universalis complicating dermatomyositis‐its treatment with Na2EDTA. Report of two cases in children
Authors: Herd J. Kenneth , Vaughan John H. 
Published: February 2007

AbstractThe treatment of calcinosis by chelation in two children with dermatomyositis is described. The amount of calcium in skin, muscle and fascia was chemically determined before and after chelation in one child. The amount in fascia was strikingly less after chelation than before chelation, though still elevated. Neither child showed clinical improvement. Treatment of calcinosis with chelating agents might be more effective if the drug were given over more prolonged periods.
Enzymatic degradation of chondromucoprotein by cell‐free extracts of human cartilage
Authors: Fessel Jon Michael , Chrisman O. Donald 
Published: February 2007

AbstractNormal and fibrillated human articular cartilage contains significant levels of an agent which reduces the viscosity of cartilage protein‐polysaccharides. This agent is cyanide and heat sensitive and has typical enzyme behavior. It splits the mucoprotein at or near the P‐P bond. This enzyme may initiate the degradation of ground substance seen in early osteoarthritis.
Aseptic necrosis in systemic lupus erythematosus. Report of a case involving six joints
Authors: Ruderman Mark , McCarty Daniel J. 
Published: February 2007

AbstractAseptic necrosis involving 6 joints (shoulders, hips, one knee and one ankle) is described in a young woman with systemic lupus erythematosus (SLE) treated with systemic corticosteroids. This is the largest number of joints involved by this process in a single case yet reported. Vasculitis, with ischemia of bone, is thought to be the pathogenesis of the necrotic changes observed.
Renal lesions associated with gold therapy light and electron microscopic studies
Authors: Lee John C. , Dushkin Miriam , Eyring E. J. , Engleman E. P. , Hopper James 
Published: February 2007

AbstractLight and electron microscopic studies were performed on renal biopsies of three patients who developed proteinuria following injections of gold in the treatment of rheumatoid arthritis. The renal lesions were shown to be lipoid nephrosis in one patient and membranous glomerulonephritis in two patients. One of the three cases developed a typical nephrotic syndrome. In the cases presented, gold was felt to be the antigenic stimulus promoting the development of the renal lesion.
Iron metabolism in rheumatoid arthritis
Authors: Raymond F. Douglas , Bowie Morris A. , Dugan Ann 
Published: February 2007

AbstractPatients with rheumatoid arthritis were found to have a rapid plasma clearance of iron, a low serum iron, and a diminished absorption of iron from the gastrointestinal tract. These abnormalities appear to be manifestations of an abnormal iron metabolism which is probably present in all patients with rheumatoid arthritis. Anemia represents the end result of the more severe degrees of the abnormality. Chronic blood loss, hemolysis, increased blood volume, and bone marrow depression represent secondary complications superimposed on the underlying abnormality.
Staphylococcus suppurative arthritis occurring in neuropathic knee joints a report of four cases with a discussion of the mechanisms involved
Authors: Martin John R. , Root Howard S. , Kim Soon Ok , Johnson Louis G. 
Published: February 2007

AbstractSuppurative arthritis in a Charcot's joint is rare. Four patients with this complication were observed; in all of them infection was due to Staphylococcus pyogenes. Both knees were infected in one patient but in the other three the process was monoarticular. The infection appears to have been born by the lymphatic or vascular channels to the joint with the possible exception of one knee of the patient with bilateral involvement where invasion from neighboring tissues could not be excluded.
Diagnostic specificity and possible pathogenetic significance of inclusions in synovial leucocytes
Authors: Astorga Gonzalo , Bollet Alfred Jay 
Published: February 2007

AbstractSynovial fluid leucocytes from 70 patients with rheumatoid arthritis contained cytoplasmic inclusions; homogenates of these cells gave positive tests for rheumatoid factor in 66 (94 per cent), including 15 who had no demonstrable rheumatoid factor in serum or synovial fluid. Similar inclusions were seen in 14 of 71 patients with other rheumatic diseases, but only 3 (4 per cent) gave positive tests for rheumatoid factor. The inclusions apparently consisted of phagocytized precipitates containing rheumatoid factor; in vitro phagocytosis of rheumatoid factor‐fraction II precipitates activated lysosomal enzymes.