bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reducing the effective dose of cisplatin using cobalt modified silver nano-hybrid as a carriers on MCF7 and HCT cell models
Authors: Faid Amna H. , Ramadan Marwa A. 
Published: April 2024

AbstractCancer is a deadly illness with a convoluted pathogenesis. The most prevalent restrictions that frequently result in treatment failure for cancer chemotherapy include lack of selectivity, cytotoxicity, and multidrug resistance. Thus, considerable efforts have been focused in recent years on the establishment of a modernistic sector termed nano-oncology, which offers the option of employing nanoparticles (NPs) with the objective of detecting, targeting, and treating malignant disorders. NPs offer a focused approach compared to conventional anticancer methods, preventing negative side effects. In the present work, a successful synthetic process was used to create magnetic cobalt cores with an AgNPs shell to form bimetallic nanocomposites CoAg, then functionalized with Cis forming novel CoAg@Cis nanohybrid. The morphology and optical properties were determined by TEM, DLS, FTIRs and UV–vis spectroscopy, furthermore, anticancer effect of CoAg and CoAg@Cis nanohybrids were estimated using MTT assay on MCF7 and HCT cell lines. Our results showed that Co@Ag core shell is about 15 nm were formed with dark CoNPs core and AgNPs shell with less darkness than the core, moreover, CoAg@Cis has diameter about 25 nm which are bigger in size than Co@Ag core shell demonstrating the loading of Cis. It was observed that Cis, CoAg and CoAg@Cis induced a decline in cell survival and peaked at around 65%, 73%and 66% on MCF7 and 80%, 76%and 78% on HCT at 100 µg/ml respectively. Compared to Cis alone, CoAg and CoAg@Cis caused a significant decrease in cell viability. These findings suggest that the synthesized CoAg can be used as a powerful anticancer drug carrier.
Graphical Abstract
Neuroinflammation increases oxygen extraction in a mouse model of Alzheimer’s disease
Authors: Liu Chang , Cárdenas-Rivera Alfredo , Teitelbaum Shayna , Birmingham Austin , Alfadhel Mohammed , Yaseen Mohammad A. 
Published: April 2024

Abstract
Background
Neuroinflammation, impaired metabolism, and hypoperfusion are fundamental pathological hallmarks of early Alzheimer’s disease (AD). Numerous studies have asserted a close association between neuroinflammation and disrupted cerebral energetics. During AD progression and other neurodegenerative disorders, a persistent state of chronic neuroinflammation reportedly exacerbates cytotoxicity and potentiates neuronal death. Here, we assessed the impact of a neuroinflammatory challenge on metabolic demand and microvascular hemodynamics in the somatosensory cortex of an AD mouse model.

Methods
We utilized in vivo 2-photon microscopy and the phosphorescent oxygen sensor Oxyphor 2P to measure partial pressure of oxygen (pO2) and capillary red blood cell flux in cortical microvessels of awake mice. Intravascular pO2 and capillary RBC flux measurements were performed in 8-month-old APPswe/PS1dE9 mice and wildtype littermates on days 0, 7, and 14 of a 14-day period of lipopolysaccharide-induced neuroinflammation.

Results
Before the induced inflammatory challenge, AD mice demonstrated reduced metabolic demand but similar capillary red blood cell flux as their wild type counterparts. Neuroinflammation provoked significant reductions in cerebral intravascular oxygen levels and elevated oxygen extraction in both animal groups, without significantly altering red blood cell flux in capillaries.

Conclusions
This study provides evidence that neuroinflammation alters cerebral oxygen demand at the early stages of AD without substantially altering vascular oxygen supply. The results will guide our understanding of neuroinflammation’s influence on neuroimaging biomarkers for early AD diagnosis.
Factors associated with adverse outcome among children with sickle cell disease admitted to the pediatric intensive care unit: an observational cohort
Authors: Levy Michaël , Naudin Jérôme , Geslain Guillaume , Maroni Arielle , Koehl Bérengère , Le Bourgeois Fleur , Poncelet Géraldine , Chomton Maryline , Deho Anna , Julliand Sébastien , Dauger Stéphane , Sommet Julie 
Published: April 2024

Abstract
Background
Sickle cell disease (SCD) is one of the most frequent inherited diseases in the world. Over the last decades, in high-income countries, an important decrease in mortality have been observed due to the improvement of care. However, children with SCD can become critically ill and require admission in Pediatric Intensive Care Units (PICU). The purpose of this study was to describe the epidemiology of children with SCD admitted to PICU for acute crisis and to identify factors associated with adverse outcome (AO).

Methods
We conducted a retrospective study in a Tertiary Hospital in France including all consecutive children with SCD admitted to PICU between January 1st, 2009 and December 31, 2019. We collected baseline patient’s characteristics, clinical and biological data as well as treatments and life sustaining therapies used in the PICU. Patients were defined as experiencing AO in case of death during stay and/or need for invasive mechanical ventilation (MV) and/or for non-invasive ventilation (NIV) for more than 3 days and/or need for vasopressors and/or need for renal replacement therapy.

Results
We included 579 admissions in 395 patients, mainly of SS genotype (90%) with a median age of 9.2 years [5.5–13.4] and a median baseline hemoglobin of 8.0 g/dl (7.5–8.8). The two main reasons for admission were acute chest syndrome (ACS) (n = 331, 57%) and vaso-occlusive crisis refractory to first line therapy (n = 99, 17%). Half of patients required NIV and 47 (8%) required MV. The overall length of stay was 3 days [1–4] and seven (1%) patients died during PICU stay.There was a total of 113 (20%) admissions with AO and on multivariable analysis, baseline hemoglobin < 8 g/dL, history of bronchial obstruction and admission for ACS were associated with AO. There was no difference in the proportion of hydroxyurea treatment or exchange transfusion program between patients with AO and the other patients.

Conclusions
Baseline hemoglobin < 8 g/dL, history of bronchial obstruction and admission for ACS were the strongest risk factors for severe evolution in SCD children admitted to PICU. These factors could be taken into consideration when choosing the adequate therapeutic options.
Oxygenation management during veno-arterial ECMO support for cardiogenic shock: a multicentric retrospective cohort study
Authors: Winiszewski Hadrien , Vieille Thibault , Guinot Pierre-Grégoire , Nesseler Nicolas , Le Berre Mael , Crognier Laure , Roche Anne-Claude , Fellahi Jean-Luc , D’Ostrevy Nicolas , Ltaief Zied , Didier Juliette , Arab Osama Abou , Meslin Simon , Scherrer Vincent , Besch Guillaume , Monnier Alexandra , Piton Gael , Kimmoun Antoine , Capellier Gilles 
Published: April 2024

AbstractBackgoundHyperoxemia is common and associated with poor outcome during veno-arterial extracorporeal membrane oxygenation (VA ECMO) support for cardiogenic shock. However, little is known about practical daily management of oxygenation. Then, we aim to describe sweep gas oxygen fraction (FSO2), postoxygenator oxygen partial pressure (PPOSTO2), inspired oxygen fraction (FIO2), and right radial arterial oxygen partial pressure (PaO2) between day 1 and day 7 of peripheral VA ECMO support. We also aim to evaluate the association between oxygenation parameters and outcome. In this retrospective multicentric study, each participating center had to report data on the last 10 eligible patients for whom the ICU stay was terminated. Patients with extracorporeal cardiopulmonary resuscitation were excluded. Primary endpoint was individual mean FSO2during the seven first days of ECMO support (FSO2 mean (day 1−7)).ResultsBetween August 2019 and March 2022, 139 patients were enrolled in 14 ECMO centers in France, and one in Switzerland. Among them, the median value for FSO2 mean (day 1−7)was 70 [57; 79] % but varied according to center case volume. Compared to high volume centers, centers with less than 30 VA-ECMO runs per year were more likely to maintain FSO2≥ 70% (OR 5.04, CI 95% [1.39; 20.4],p = 0.017). Median value for right radial PaO2 mean (day 1−7)was 114 [92; 145] mmHg, and decreased from 125 [86; 207] mmHg at day 1, to 97 [81; 133] mmHg at day 3 (p < 0.01). Severe hyperoxemia (i.e. right radial PaO2≥ 300 mmHg) occurred in 16 patients (12%). PPOSTO2, a surrogate of the lower body oxygenation, was measured in only 39 patients (28%) among four centers. The median value of PPOSTO2 mean (day 1−7)value was 198 [169; 231] mmHg. By multivariate analysis, age (OR 1.07, CI95% [1.03–1.11],p < 0.001), FSO2 mean (day 1−3)(OR 1.03 [1.00-1.06],p = 0.039), and right radial PaO2 mean (day 1−3)(OR 1.03, CI95% [1.00-1.02],p = 0.023) were associated with in-ICU mortality.ConclusionIn a multicentric cohort of cardiogenic shock supported by VA ECMO, the median value for FSO2 mean (day 1−7)was 70 [57; 79] %. PPOSTO2monitoring was infrequent and revealed significant hyperoxemia. Higher FSO2 mean (day 1−3)and right radial PaO2 mean (day 1−3)were independently associated with in-ICU mortality.
Provably secure data selective sharing scheme with cloud-based decentralized trust management systems
Authors: Velmurugan S. , Prakash M. , Neelakandan S. , Radhakrishnan Arun 
Published: April 2024

AbstractThe smart collection and sharing of data is an important part of cloud-based systems, since huge amounts of data are being created all the time. This feature allows users to distribute data to particular recipients, while also allowing data proprietors to selectively grant access to their data to users. Ensuring data security and privacy is a formidable task when selective data is acquired and exchanged. One potential issue that emerges is the risk that data may be transmitted by cloud servers to unauthorized users or individuals who have no interest in the particular data or user interests. The prior research lacks comprehensive solutions for balancing security, privacy, and usability in secure data selective sharing schemes inside Cloud-Based decentralized trust management systems. Motivating factors for settling this gap contain growing concerns concerning data privacy, the necessity for scalable and interoperable frameworks, and the increasing dependency on cloud services for data storage and sharing, which necessitates robust and user-friendly mechanisms for secure data management. An effective and obviously secure data selective sharing and acquisition mechanism for cloud-based systems is proposed in this work. We specifically start by important a common problematic related to the selective collection and distribution of data in cloud-based systems. To address these issues, this study proposes a Cloud-based Decentralized Trust Management System (DTMS)-connected Efficient, Provably Secure Data Selection Sharing Scheme (EPSDSS). The EPSDSS approach employs attribute-based encryption (ABE) and proxy re-encryption (PRE) to provide fine-grained access control over shared data. A decentralized trust management system provides participant dependability and accountability while mitigating the dangers of centralized trust models. The EPSDSS-PRE paradigm would allow data owners to regulate granular access while allowing users to customize data collection without disclosing their preferences. In our strategy, the EPSDSS recognizes shared data and generates short fingerprints for information that can elude detection before cloud storage. DTMS also computes user trustworthiness and improves user behaviour administration. Our research demonstrates that it’s able to deliver trustworthy and safe data sharing features in cloud-based environments, making it a viable option for enterprises seeking to protect sensitive data while maximizing collaboration and utilization of resources.
Unilateral abnormality of initial motor-evoked potential in the upper limb detected during lumbar spine surgery: a case report
Authors: Phoowanakulchai Sirima , Hayashi Hironobu , Oi Ayako , Takeshima Yasuhiro , Takatani Tsunenori , Kawaguchi Masahiko 
Published: April 2024

Abstract
Background
We present a case with abnormal findings of initial motor-evoked potential (MEP) in the left upper limb after prone positioning during lumbar spine surgery.

Case presentation
A 71-year-old man with bilateral lower extremity numbness without a history of preexisting motor weakness underwent L3–5 spinal fenestration. Initial MEP monitoring after prone positioning revealed markedly prolonged latency and lower amplitude in the left abductor pollicis brevis (APB). Because the left upper limb somatosensory-evoked potentials had normal values, a position-related impending peripheral nerve injury located between the neck and the forearm was excluded. Postoperative examination revealed that MEP abnormality in the left APB was caused by carpal tunnel syndrome.

Conclusions
Abnormal initial MEP from the upper limb was unexpectedly detected after prone positioning during lumbar spine surgery. The condition was caused by preexisting carpal tunnel syndrome.
A Challenging Case of Diabetes in a Patient With XXYY Syndrome
Authors: Bernacet Rivera Luisa M , Aftab Hassaan B , Mirza Faryal S 
Published: April 2024

Abstract
48 XXYY syndrome is a rare polyploidy often compared with Klinefelter syndrome because of shared features such as tall stature, neurocognitive diseases, hypogonadism, and cardiac malformations. This population is believed to be predisposed to type 2 diabetes because of the presence of hypogonadism and central adiposity. We present a patient with XXYY syndrome who had an atypical and difficult-to-manage diabetes presentation. The patient was nonadherent to medication regimen with poorly controlled diabetes and hemoglobin A1c ranging from 12% to 14% (16.5-19.6 mmol/L). He lacked history of diabetes ketoacidosis, raising the question of maturity-onset diabetes of the young. Workup was negative for glutamic acid decarboxylase-65 and pancreatic islet cell antibody testing. Genetic testing for 5-gene panel for maturity-onset diabetes of the young was also negative. Distinct parts of his presentation make an accurate diabetes diagnosis very challenging. Clinicians should be aware of diabetes associations in patients with XXYY syndrome for optimization of care.
Managing Catecholamine Release Syndrome During and Following Lu-177-DOTATATE in High-Risk Pheochromocytoma Patients
Authors: Phelps Tim E , del Rivero Jaydira , Chertow Daniel S , Rosing Douglas , Pacak Karel , Lin Frank I 
Published: April 2024

Abstract
Pheochromocytomas and paragangliomas (PPGLs) are rare catecholamine-producing tumors that express somatostatin receptors (SSTR) that can be treated with lutetium-177 DOTATATE (Lu-177-TRT); however, treatment can be associated with life-threatening cardiovascular events. A patient case with management strategies for high-risk PPGL patients receiving Lu-177-TRT is described. The 78-year-old patient with metastatic paraganglioma was enrolled and treated under NCT03206060. Deemed to be at high risk, the patient was preemptively admitted to the intensive care unit (ICU) with central line access placed. Due to comorbidities, a reduced dose of 100 mCi x 4 cycles was used for this patient. Vital signs, blood work, and serum catecholamine levels were obtained at various time points. Despite reduced dosing, the patient still developed a severe hypertensive reaction with systolic blood pressure of 240 mmHg within minutes of Lu-177-TRT infusion, which was controlled with an intravenous nicardipine drip. The patient remained in the ICU for 24 hours post Lu-177-TRT before moving to an inpatient ward for an additional 24 hours. All subsequent infusions were performed using reduced doses with elective ICU admissions and were well-tolerated. Despite the increased risk, metastatic PPGL patients can be safely treated with proper staff training, monitoring, and preparation for intravenous medications, especially nicardipine.
A Longitudinal Theory-Based Investigation of How Environmental Aesthetics Predicts Home-Based Exercise
Authors: KAUSHAL NAVIN , NEMATI DONYA , KEITH NICOLE , HAGGER MARTIN 
Published: April 2024

ABSTRACT

Introduction
Environmental aesthetics is a recognized macro environmental correlate of physical activity participation. Extrapolating this effect, we hypothesize this variable to also function as a determinant of exercise participation in the microenvironment, such as the home. Specifically, we predict that the environmental aesthetics of the location of cardio and resistance training equipment will predict determinants of exercise participation within the integrated behavior change model.

Methods
Adult owners of exercise equipment (N = 231) completed measures on the environmental aesthetics of their cardio and resistance training equipment, exercise time, and constructs from the integrated behavior change model across three consecutive monthly surveys. Study hypotheses were tested using multilevel structural equation modeling with participants (level 2) nested within time (level 1).

Results
The model revealed predictive effects of intention, habit, and planning on exercise participation over time. The findings indicated a total effect of autonomous motivation on intention and habit. In addition, environmental aesthetics of cardio and strength training equipment predicted autonomous motivation, along with habit and intention when accounting for indirect effects. Finally, planning moderated the intention–behavior relationship, indicating that participants who scored higher on planning were more likely to translate their intentions to behavior.

Conclusions
These findings provide informative notes for designing effective home-based exercise programs, which have increased in popularity over the past recent years. Specifically, experimental studies that provide exercise equipment should ensure that the location of the equipment is appealing to the participant to increase the likelihood equipment use and exercise engagement.
Broadband intelligent programmable metasurface with polarization-modulated self-adaptive electromagnetic functionality switching
Authors: Li Ximing , Xu Rui , Sun Xiaofeng , Zhao Yuan , Yang Zhao , Du Guohong 
Published: April 2024

Programmable metasurfaces have received a great deal of attention due to their ability to dynamically manipulate electromagnetic (EM) waves. Despite the rapid growth, most of the existing metasurfaces require manual control to switch among different functionalities, which poses severe limitations on practical applications. Here, we put forth an intelligent metasurface that has self-adaptive EM functionality switching in broadband without human participation. It is equipped with polarization discrimination antennas (PDAs) and feedback components to automatically adjust functionalities for the different incident polarization information. The PDA module can first perceive the polarization of incident EM waves, e.g., linear or circular polarization, and then provide the feedback signal to the controlling platform for switching the EM functionality. As exemplary demonstrations, a series of functionalities in the 9–22 GHz band has been realized, including beam scanning for x-polarization, specular reflection for y-polarization, diffuse scattering for left-handed circular polarization (LCP), and vortex beam generation for right-handed circular polarization (RCP) waves. Experiments verify the good self-adaptive reaction capability of the intelligent metasurface and are in good agreement with the designs. Our strategy provides an avenue toward future unmanned devices that are consistent with the ambient environment.
Severe leptospirosis in tropical and non-tropical areas: A comparison of two french, multicentre, retrospective cohorts
Authors: Allyn Jérôme , Miailhe Arnaud-Félix , Delmas Benjamin , Marti Lucas , Allou Nicolas , Jabot Julien , Reignier Jean 
Published: April 2024

Background
Leptospirosis is an anthropozoonosis that occurs worldwide but is more common in tropical regions. Severe forms may require intensive care unit (ICU) admission. Whether the clinical patterns and outcomes differ between tropical and non-tropical regions with similar healthcare systems is unclear. Our objective here was to address this issue by comparing two cohorts of ICU patients with leptospirosis managed in mainland France and in the overseas French department of Réunion, respectively.

Methodology/Principal findings
We compared two retrospective cohorts of patients admitted to intensive care for severe leptospirosis, one from Reunion Island in the Indian Ocean (tropical climate) and the other from metropolitan France (temperate climate). Chi-square and Student’s t tests were used for comparisons. After grouping the two cohorts, we also performed multiple correspondence analysis and hierarchical clustering to search for distinct clinical phenotypes. The Réunion and Metropolitan France cohorts comprised 128 and 160 patients respectively. Compared with the Réunion cohort, the metropolitan cohort had a higher mean age (42.5±14.1 vs. 51.4±16.5 years, p<0.001). Severity scores, length of stay and mortality did not differ between the two cohorts. Three phenotypes were identified: hepato-renal leptospirosis (54.5%) characterized by significant hepatic, renal and coagulation failure, with a mortality of 8.3%; moderately severe leptospirosis (38.5%) with less severe organ failure and the lowest mortality rate (1.8%); and very severe leptospirosis (7%) manifested by neurological, respiratory and cardiovascular failure, with a mortality of 30%.

Conclusions/Significance
The outcomes of severe leptospirosis requiring ICU admission did not differ between tropical and temperate regions with similar healthcare access, practices, and resources, despite some differences in patient characteristics. The identification of three different clinical phenotypes may assist in the early diagnosis and management of severe leptospirosis.