bluuebunny/crossref_metadata_2025_split huggingface dataset:
HEPARIN-BINDING PROTEIN LEVELS PREDICT UNFAVORABLE OUTCOME IN COVID-19 PNEUMONIA: A POST HOC ANALYSIS OF THE SAVE TRIAL
Authors: Kyriazopoulou Evdoxia , Dalekos George N. , Metallidis Symeon , Poulakou Garyphalia , Papanikolaou Ilias C. , Tzavara Vasiliki , Argyraki Katerina , Alexiou Zoi , Panagopoulos Periklis , Samarkos Michael , Chrysos George , Tseliou Aikaterini , Milionis Haralampos , Sympardi Styliani , Vasishta Anil , Giamarellos-Bourboulis Evangelos J. 
Published: March 2024

ABSTRACTWe aimed to evaluate heparin-binding protein (HBP) as a marker of prognosis of unfavorable outcome in COVID-19 pneumonia. This was a post hoc analysis of the SAVE clinical trial investigating anakinra treatment, guided by suPAR (soluble urokinase plasminogen activator receptor) levels ≥6 ng/mL, for the prevention of severe respiratory failure in hospitalized patients with COVID-19 pneumonia. Baseline HBP plasma levels were measured in 534 patients by fluorescence dry quantitative immunoassay using the Jet-iStar 800 analyzer. Concentrations higher than 35 ng/mL predicted 30-day mortality with a moderate specificity of 53.3% and negative predictive value 78.1%; sensitivity was low (29.0%). After multivariate Cox analysis, HBP higher than 35 ng/mL was an independent predictor of 30-day unfavorable outcome (adjusted hazard ratio, 1.77; 95% CI, 1.06–2.94;P= 0.028) and these patients were also at greater risk of death after 90 days (hazard ratio, 1.85; 95% CI, 1.25–2.74;P= 0.002). The cutoff was not predictive of development of severe respiratory failure, septic shock or acute kidney injury. Among patients with baseline HBP levels higher than 35 ng/mL, anakinra treatment was associated with decreased mortality (7.2%)versuscomparators (18.1%;P< 0.001). Results confirm that HBP may be an early biomarker of poor outcome among preselected patients at risk from COVID-19 pneumonia.ClinicalTrials.gov registration NCT04357366.
Long-term Outcomes following Resection of Adenocarcinoma Arising from Intraductal Papillary Mucinous Neoplasm (A-IPMN) versus Pancreatic Ductal Adenocarcinoma (PDAC)
Authors: Lucocq James , Halle-Smith James , Haugk Beate , Joseph Nejo , Hawkyard Jake , Lye Jonathan , Parkinson Daniel , White Steve , Mownah Omar , Zen Yoh , Menon Krishna , Furukawa Takaki , Inoue Yosuke , Hirose Yuki , Sasahira Naoki , Mittal Anubhav , Samra Jas , Sheen Amy , Feretis Michael , Balakrishnan Anita , Ceresa Carlo , Davidson Brian , Pande Rupaly , Dasari Bobby V.M. , Tanno Lulu , Karavias Dimitrios , Helliwell Jack , Young Alistair , Marks Kate , Nunes Quentin , Urbonas Tomas , Silva Michael , Gordon-Weeks Alex , Barrie Jenifer , Gomez Dhanny , van Laarhoven Stijn , Nawara Hossam , Doyle Joseph , Bhogal Ricky , Harrison Ewen , Roalso Marcus , Ciprani Debora , Aroori Somaiah , Ratnayake Bathiya , Koea Jonathan , Capurso Gabriele , Bellotti Ruben , Stättner Stefan , Alsaoudi Tareq , Bhardwaj Neil , Rajesh Srujan , Jeffery Fraser , Connor Saxon , Cameron Andrew , Jamieson Nigel , Soreide Kjetil , Gill Anthony J. , Roberts Keith , Pandanaboyana Sanjay 
Published: March 2024

Objective:
The aim of the present study was to compare long-term post-resection oncological outcomes between A-IPMN and PDAC.

Summary Background Data:
Knowledge of long term oncological outcomes (e.g recurrence and survival data) comparing between adenocarcinoma arising from intraductal papillary mucinous neoplasms (A-IPMN) and pancreatic ductal adenocarcinoma (PDAC) is scarce.

Methods:
Patients undergoing pancreatic resection (2010-2020) for A-IPMN were identified retrospectively from 18 academic pancreatic centres and compared with PDAC patients from the same time-period. Propensity-score matching (PSM) was performed and survival and recurrence were compared between A-IPMN and PDAC.

Results:
459 A-IPMN patients (median age,70; M:F,250:209) were compared with 476 PDAC patients (median age,69; M:F,262:214). A-IPMN patients had lower T-stage, lymphovascular invasion (51.4%vs. 75.6%), perineural invasion (55.8%vs. 71.2%), lymph node positivity (47.3vs. 72.3%) and R1 resection (38.6%vs. 56.3%) compared to PDAC(P<0.001). The median survival and time-to-recurrence for A-IPMN versus PDAC were 39.0 versus19.5months (P<0.001) and 33.1 versus 14.8months (P<0.001), respectively (median follow-up,78 vs.73 months). Ten-year overall survival for A-IPMN was 34.6%(27/78) and PDAC was 9%(6/67). A-IPMN had higher rates of peritoneal (23.0 vs. 9.1%, P<0.001) and lung recurrence (27.8% vs. 15.6%, P<0.001) but lower rates of locoregional recurrence (39.7% vs. 57.8%; P<0.001). Matched analysis demonstrated inferior overall survival (P=0.005), inferior disease-free survival (P=0.003) and higher locoregional recurrence (P<0.001) in PDAC compared to A-IPMN but no significant difference in systemic recurrence rates (P=0.695).

Conclusions:
PDACs have inferior survival and higher recurrence rates compared to A-IPMN in matched cohorts. Locoregional recurrence is higher in PDAC but systemic recurrence rates are comparable and constituted by their own distinctive site-specific recurrence patterns.
Gummatous mitral valve endocarditis from tertiary syphilis
Authors: George Nisha , Pan Daniel , Sze Shirley , Williams Caroline , El-Dean Zein , Zlocha Victor , Webb Elizabeth , Pareek Manish 
Published: March 2024

A 50-year old Romanian gentleman presented with fever, myalgia and 30kg weight loss. He was treated for syphilis previously, after acquiring it from his ex-wife 16 years ago. On examination, there was a pansystolic murmur in the axilla, and the patient had an ataxic gait. Blood tests showed raised inflammatory markers. However, standard investigations for infective endocarditis, including multiple blood cultures, serological titres for fastidious organisms and antibody tests were negative.

CT of the chest, abdomen and pelvis demonstrated hepatosplenomegaly with multiple splenic infarcts. MRI of the head with contrast showed multiple punctate enhancement in the bilateral hemispheres with leptomeningeal enhancement. Transthoracic echocardiogram demonstrated large vegetation leading to severe mitral regurgitation. Serum treponemal antibodies were positive; TPPA was positive at 1:1280 and RPR: 1:4 Treponemal IgM was negative; lumbar puncture syphilis serology was negative. The patient was treated with an extensive period of intravenous antibiotics, in addition to a prosthetic metallic valve replacement, where unusual ragged calcified valvular tissue was observed.

Tertiary syphilis is a difficult diagnosis to confirm, since it can often be indolent and occur in areas of the body where they may go unnoticed. In our case, a diagnosis of syphilitic endocarditis was made from a combination of the history, an initial increase in size of the lesion following antibiotic therapy and observation of likely gumma on the mitral valve during surgery. In such cases, surgery in addition to optimal antimicrobial therapy is necessary for effective treatment.
The PRC2.1 Subcomplex Opposes G1 Progression through Regulation of CCND1 and CCND2
Authors: Longhurst Adam D. , Wang Kyle , Suresh Harsha Garadi , Ketavarapu Mythili , Ward Henry N. , Jones Ian R. , Narayan Vivek , Hundley Frances V. , Hassan Arshia Zernab , Boone Charles , Myers Chad L. , Shen Yin , Ramani Vijay , Andrews Brenda J. , Toczyski David P. 
Published: March 2024

AbstractProgression through the G1 phase of the cell cycle is the most highly regulated step in cellular division. We employed a chemogenetic approach to discover novel cellular networks that regulate cell cycle progression. This approach uncovered functional clusters of genes that altered sensitivity of cells to inhibitors of the G1/S transition. Mutation of components of the Polycomb Repressor Complex 2 rescued proliferation inhibition caused by the CDK4/6 inhibitor palbociclib, but not to inhibitors of S phase or mitosis. In addition to its core catalytic subunits, mutation of the PRC2.1 accessory protein MTF2, but not the PRC2.2 protein JARID2, rendered cells resistant to palbociclib treatment. We found that PRC2.1 (MTF2), but not PRC2.2 (JARID2), was critical for promoting H3K27me3 deposition at CpG islands genome-wide and in promoters. This included the CpG islands in the promoter of the CDK4/6 cyclins CCND1 and CCND2, and loss of MTF2 lead to upregulation of both CCND1 and CCND2. Our results demonstrate a role for PRC2.1, but not PRC2.2, in antagonizing G1 progression in a diversity of cell linages, including CML, breast cancer and immortalized cell lines.
Electroantennography Responses of African Meliponine Bee Species (Hymenoptera: meliponini) to Hetero-Specific Trail Pheromones: Glandular Sequestration of Terpenyl Esters
Authors: Bobadoye Bridget O. , Nganso Beatrice T. , Kiatoko N 
Published: March 2024

ABSTRACTPreliminary studies of electroantennographic responses of African meliponine bees to trail pheromones were performed using four meliponine species;Hypotrigona gribodoi, Meliponula ferruginea(black),Meliponula ferruginea(reddish brown) andMelipona bocandei. Experiments withMeliponula ferruginea(black) and (reddish brown) revealing antennae responses to pentane extracts containing the nasonov gland and tarsal glands respectively. Because the glandular origin of pheromone marks deposited by African meliponine bee’s species has not yet been investigated, we first confirmed if these species carry out scent marking and recruitment behavior at floral sources. Secondly we tested if either nasonov or tarsal gland secretions elicited trail-following behavior in newly recruited bees by means of chemical and electrophysiological analyses as well as with bio-assays testing both natural extracts and synthetic pheromone compounds from both glands. A significantly higher proportion of foragers from the four species were attracted and recruited additional foragers to floral resources baited with natural extracts from their own tarsal and nasonov glands. The dominant compound from postpharyngeal gland extracts detected by the chemo-receptors on the foragers’ antennae from these four species belongs to the chemical class of terpenoid esters, with (E)-β Farnesene constituting a dominant part of this trail pheromone in all four species. This terpenoid could potentially be a singular olfactory cue with dual functionality for resource partitioning and competition avoidance between con-specific and hetero-specific foragers on floral resources, which commonly occurs when foragers from different colonies are scouting for food sources in overlapping foraging areas.
Navigating the Multiverse: A Hitchhiker’s Guide to Selecting Harmonisation Methods for Multimodal Biomedical Data
Authors: Magateshvaren Saras Murali Aadhitya , Mitra Mithun K. , Tyagi Sonika 
Published: March 2024

AbstractIntroductionThe application of machine learning (ML) techniques in classification and prediction tasks has greatly advanced our comprehension of biological systems. There is a notable shift in the trend towards integration methods that specifically target the simultaneous analysis of multiple modes or types of data, showcasing superior results compared to individual analyses. Despite the availability of diverse ML architectures for researchers interested in embracing a multimodal approach, the current literature lacks a comprehensive taxonomy that includes the pros and cons of these methods to guide the entire process. Closing this gap is imperative, necessitating the creation of a robust framework. This framework should not only categorise the diverse ML architectures suitable for multimodal analysis but also offer insights into their respective advantages and limitations. Additionally, such a framework can act as a guide for selecting an appropriate workflow for multimodal analysis. This comprehensive taxonomy would furnish a clear guidance and aid in informed decision-making within the progressively intricate realm of biomedical and clinical data analysis, and is imperative for advancing personalised medicine.ObjectiveThe aims of the work are to comprehensively study and describe the harmonisation processes that are performed and reported in the literature and present a working guide that would enable planning and selecting an appropriate integrative model.ResultsWe present harmonisation as a dual process of representation and integration, each with multiple methods and categories. The taxonomy of the various representation and integration methods are classified into six broad categories and detailed with the advantages, disadvantages and examples. A guide flowchart that describes the step-by-step processes that are needed to adopt a multimodal approach is also presented along with examples and references.ConclusionsThis review provides a thorough taxonomy of methods for harmonising multimodal data and introduces a foundational 10-step guide for newcomers to implement a multimodal workflow.
Precision Electroconvulsive Therapy (PET) project: tackling (cost) effectiveness and patient’s perspectives
Authors: van Eijndhoven Philip , Tendolkar Indira , Loef Dore , Rovers Jordy , Somers Metten , Spaans Harm Pieter , van Waarde Jeroen , Schut Bart , Wijnen Ben , Verwijk Esmée , Dols Annemieke 
Published: March 2024

AbstractBackgroundDepression puts a great burden on both patients, relatives and society as a whole. Electroconvulsive therapy (ECT) is regarded as a safe and effective treatment for severe and chronic depressive episodes, even when other interventions such as psychotherapy or psychopharmacology have failed. Despite its superior efficacy, use of ECT for depressed patients is surprisingly low in most European countries as exemplified in a recent Dutch study. This low application rate is possibly due to (1) limited knowledge on the optimal position of ECT in the treatment algorithms, (2) a lack of knowledge on cost-effectiveness, (3) fear for (cognitive) side-effects in patients, relatives and professionals, and (4) the outdated representation of ECT in the media and society at large.MethodsThe present study will overcome the aforementioned limitations and setup a large database of merged clinical and research cohorts of ECT-patients (N=±1500) and an observational prospective cohort study, in order to analyze aspects of (cost-) effectiveness and side-effects of ECT in retro- and prospective Dutch data. Using these results and together with qualitative information from patients and their relatives, we will disseminate the gained knowledge and develop with a decision-making tool that will guide future patients and their family members referred for ECT.DiscussionOur project will further clarify the position of ECT in treatment algorithms for depression based on scientific data, including data on cost-effectiveness, cognitive side-effects and needs of the patients in the decision-making process. By these means, it will contribute to the development of successful personalized treatment and preventive strategies also in other countries in cooperation with stakeholders such as national and international commissions.
Redirecting the pioneering function of FOXA1 with covalent small molecules
Authors: Won Sang Joon , Zhang Yuxiang , Reinhardt Christopher J. , MacRae Nicole S. , DeMeester Kristen E. , Njomen Evert , Hargis Lauren M. , Remsberg Jarrett R. , Melillo Bruno , Cravatt Benjamin F. , Erb Michael A. 
Published: March 2024

SummaryPioneer transcription factors (TFs) exhibit a specialized ability to bind to and open closed chromatin, facilitating engagement by other regulatory factors involved in gene activation or repression. Chemical probes are lacking for pioneer TFs, which has hindered their mechanistic investigation in cells. Here, we report the chemical proteomic discovery of electrophilic small molecules that stereoselectively and site-specifically bind the pioneer TF, FOXA1, at a cysteine (C258) within the forkhead DNA-binding domain. We show that these covalent ligands react with FOXA1 in a DNA-dependent manner and rapidly remodel its pioneer activity in prostate cancer cells reflected in redistribution of FOXA1 binding across the genome and directionally correlated changes in chromatin accessibility. Motif analysis supports a mechanism where the covalent ligands relax the canonical DNA binding preference of FOXA1 by strengthening interactions with suboptimal ancillary sequences in predicted proximity to C258. Our findings reveal a striking plasticity underpinning the pioneering function of FOXA1 that can be controlled by small molecules.
Fear of being replaced: The dark side of employee ambassadorship on social media
Authors: Sossini Alessandra , Heide Mats 
Published: March 2024

PurposeThis study problematizes the prevailing normative and managerial-dominated view of self-initiated employee ambassadorship on social media from a power perspective. The aim is to provide a more nuanced and critical understanding of the negative aspects of this phenomenon.Design/methodology/approachThe empirical material encompasses qualitative interviews with employees from 14 organizations and Foucault’s concept of disciplinary discursive power to analyze which and how discourses exert power over employee communication on social media and what role visibility plays in it.FindingsThis study indicates that employee ambassadors’ social media communication is governed by two discourses that create complex tensions, where ambassadors constantly must negotiate between self-branding requirements and an authenticity paradox. These tensions intensify through visibility on social media, where employees strategize and situationally silence their communication through self-monitoring and self-surveillance practices. Conclusively, the findings also outline the need for further critical research to offer a deeper understanding of power relations that influence the communication practices of organizational members.Research limitations/implicationsThe paper contributes to a more nuanced understanding of self-initiated employee ambassadorship on social media and highlights disciplinary power relations that go beyond organizational borders.Practical implicationsThe findings underscore that organizations need to address the critical aspects of self-initiated employee ambassadorship and act as facilitators to support employees in their navigation process.Originality/valueThis paper contributes a new critical power perspective on employee ambassadorship on social media.
Can ChatGPT exceed humans in construction project risk management?
Authors: Nyqvist Roope , Peltokorpi Antti , Seppänen Olli 
Published: March 2024

PurposeThe objective of this research is to investigate the capabilities of the ChatGPT GPT-4 model, a form of artificial intelligence (AI), in comparison to human experts in the context of construction project risk management.Design/methodology/approachEmploying a mixed-methods approach, the study draws a qualitative and quantitative comparison between 16 human risk management experts from Finnish construction companies and the ChatGPT AI model utilizing anonymous peer reviews. It focuses primarily on the areas of risk identification, analysis, and control.FindingsChatGPT has demonstrated a superior ability to generate comprehensive risk management plans, with its quantitative scores significantly surpassing the human average. Nonetheless, the AI model's strategies are found to lack practicality and specificity, areas where human expertise excels.Originality/valueThis study marks a significant advancement in construction project risk management research by conducting a pioneering blind-review study that assesses the capabilities of the advanced AI model, GPT-4, against those of human experts. Emphasizing the evolution from earlier GPT models, this research not only underscores the innovative application of ChatGPT-4 but also the critical role of anonymized peer evaluations in enhancing the objectivity of findings. It illuminates the synergistic potential of AI and human expertise, advocating for a collaborative model where AI serves as an augmentative tool, thereby optimizing human performance in identifying and managing risks.
The evolution of integrated popular financial reporting: toward a digital-driven collaborative approach using sentiment analysis tool
Authors: Biancone Paolo , Brescia Valerio , Chmet Federico , Lanzalonga Federico 
Published: March 2024

PurposeThe research aims to provide a longitudinal case study to understand how digital transformation can be embedded in municipal reporting frameworks. The central role of such technology becomes increasingly evident as citizens demand greater transparency and engagement between them and governing institutions.Design/methodology/approachUtilising a longitudinal case study methodology, the research focusses on Turin’s Integrated Popular Financial Report (IPFR) as a lens through which to evaluate the broader implications of digital transformation on governmental transparency and operational efficiency.FindingsDigital tools, notably sentiment analysis, offer promising avenues for enhancing governmental efficacy and citizenry participation. However, persistent challenges highlight the inadequacy of traditional, inflexible reporting structures to cater to dynamic informational demands.Practical implicationsEmbracing digital tools is an imperative for contemporary public administrators, promoting streamlined communication and dismantling bureaucratic obstructions, all while catering to the evolving demands of an informed citizenry.Originality/valueDifferent from previous studies that primarily emphasised technology’s role within budgeting, this research uniquely positions itself by spotlighting the transformative implications of digital tools during the reporting phase. It champions the profound value of fostering bottom-up dialogues, heralding a paradigmatic shift towards co-creative public management dynamics.
Friction and wear performances of 7075 aluminum alloy surface with V-shaped microtexture via numerical simulation and experimental characterizations
Authors: Ding Cong , Qiao Zhizhao , Piao Zhongyu 
Published: March 2024

Purpose
The purpose of this study is to design and process the optimal V-shaped microstructure for 7075 aluminum alloy and reveal its wear resistance mechanism and performance.

Design/methodology/approach
The hydrodynamic pressure lubrication models of the nontextured, V-shaped, circular and square microtextures are established. The corresponding oil film pressure distributions are explored. The friction and wear experiments are conducted on a rotating device. The effects of the microstructure shapes and sizes on the wear mechanisms are investigated via the friction coefficients and surface morphologies.

Findings
In comparison, the V-shaped microtexture has the largest oil film carrying capacity and the lowest friction coefficient. The wear mechanism of the V-shaped microtexture is dominated by abrasive and adhesive wear. The V-shaped microtexture has excellent wear resistance under a side length of 300 µm, an interval of 300 µm and a depth of 20 µm.

Originality/value
This study is conductive to the design of wear-resistant surfaces for friction components.