bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of clinical and surgical‐pathologic staging in patients with endometrial carcinoma
Authors: Ayhan Ali , Yarali Hakan , Urman Bülent , Yüce Kunter , Günalp Serdar , Ayhan Ayşe , Havlioǧlu Samim 
Published: February 2007

AbstractIn that accurate staging is essential to proper management of patients with endometrium cancer, preoperative clinical staging was compared with surgical‐pathological staging in 160 patients with endometrium cancer. One hundred fifty‐two patients had clinical stage I, and eight had clinical stage II disease. Overall, the clinical stage was changed in 26.9% of patients. The incidence of inaccurate staging was 25% for clinical stage I and 62.5% for clinical stage II disease. Endocervical curettage was found to have a 12.5% false‐positive rate and an 8.6% false‐negative rate. The extent of malignant disease for endometrium cancer (clinical stages I‐II) cannot be adequately and accurately assessed with clinical staging because there is a high rate of discordance between clinical and surgical‐pathologic staging.
Invasive colorectal adenomas: Surgery versus colonoscopic polypectomy
Authors: Pines Amos , Bat Leon , Shemesh Eliahou , Ron Elaine , Horowitz Ada , Chetrit Angela , Bubis Jose J. 
Published: February 2007

AbstractOf 6,426 colonoscopies performed in 1978–1987, 66 invasive colorectal adenomatous polyps were removed in 58 examinations. The study group included 36 (62%) men and 22 (38%) women with an age range of 42–96 years. Forty‐three patients had invasive pedunculated polyps and 15 had invasive sessile polyps. Following the colonoscopic polypectomy, secondary surgical resection was done in 19 patients with pedunculated polyps and in 13 patients with sessile polyps. The operative specimens showed that the colonoscopic polypectomy removed the entire cancerous focus in all patients with pedunculated polyps, including those with stalk invasion. In contrast, most cases with sessile polyps turned out on operation to be Dukes' B or C carcinoma. Follow‐up (mean 4.4 years) was available for 53 (93%) patients: none of 24 unoperated patients with pedunculated polyps suffered from local recurrence. We conclude that colonoscopic polypectomy is sufficient for invasive pedunculated polyps, provided that histology shows that the resection margins are free of tumoral cells. Surgery is recommended for all invasive sessile polyps.
Malignant struma ovarii: Report of two cases and selected review of the literature
Authors: Zakhem Antoine , Aftimos George , Kreidy Raghid , Salem Philip 
Published: February 2007

AbstractMalignant struma ovarii is an extremely rare tumor. Two new cases are described and current perspectives provided. Both cases are examples of the mixed form of the disease, and both were treated by surgery alone. One patient underwent total hysterectomy and bilateral salpingo‐oophorectomy; the other had unilateral salpingo‐oophorectomy. Both patients remained free of recurrent disease at 20 and 33 months from diagnosis. The controversies relating to therapy and diagnosis are discussed in detail.
Do adrenal metastases from lung cancer develop by lymphogenous or hematogenous route?
Authors: Károlyi Peter 
Published: February 2007

AbstractIn order to analyse the possible mode and pathways of adrenal metastases from lung cancer, the frequency of adrenal metastases ipsilateral and contralateral to the site of the primary cancer was investigated based on autopsied lung cancer cases. In 405 of 1,607 such cases, adrenal metastases could be found: on both sides, 234; ipsilateral only, 105: contralateral only, 66 cases. In the early stages of tumor progression, a striking difference can be seen between the two sides. Ipsilateral metastases were of significantly higher incidence in early metastatic tumor stages, but later, in cases having six or more involved organs, the ipsilateral/contralateral quotient reaches 1. It is postulated that in the early stages adrenal metastases from lung cancer probably develop mainly by lymphogenous, but later mainly by hematogenous routes.
Dormancy and breast cancer
Authors: Meltzer Adolph 
Published: February 2007

AbstractA case is presented in which multiple nodules of recurrent cancer appeared about the scar 25 years after radical mastectomy. They were accompanied by an inflammatory reaction. Breast cancers may recur as long as 50 years after surgery. Such late recurrence is accomplished by the cancer cell entering a “dormant” state in which little or no de novo DNA transcription occurs and only enough RNA is translated into proteins to maintain the vegetative functions that sustain cell viability. Features favoring the evolvement of dormancy are discussed as well as the nature of the cocoon‐like shell which affords such cancer cells protection from the host's cellular and serological defenses. Speculation, promoted by the new cellular biology, as to the cause of secondary inflammatory cancers, is presented. A possible mechanism for the reactivation of these quiescent cells is suggested. The altered immune reactions of host and cancer cells provide an explanation for the controversies plaguing surgeons regarding the treatment and prognosis of breast cancer.
Role of brachytherapy in malignant melanoma: A preliminary report
Authors: Chadha Manjeet , Hilaris Basil , Nori Dattatreyudu , Shiu Man H. , Anderson Lowel L. 
Published: February 2007

AbstractFrom August 1979 to May 1986, various brachytherapy techniques were applied at Memorial Sloan Kettering Cancer Center (MSKCC) in an adjuvant setting with/without surgery and external radiation therapy in the management of advanced malignant melanoma. Thirty‐three patients underwent brachytherapy procedures. The patients' ages ranged from 35 to 82 years, with a median age of 56 years. Fourteen patients had disease localized to the implant site, whereas 19 patients also had disseminated disease elsewhere. The indications for implant were residual gross disease (21), microscopically positive margins (3), and histologically negative but clinically close margins of resection (9). Local control at the implant site was noted in 80% of patients at 6 months and 42% of patients at 1 year; two patients had reached 54 months and 72 months with no evidence of disease. Local control was 100% (9/9) in patients with histologically negative but clinically close margins of resection, and 48% (11/23) with microscopically positive margins and/or gross residual disease. Complications were seen as follows: delay in wound healing (1). wound infections (4), radiation enteritis (1), small bowel obstruction (1). The present study suggests that brachytherapy combined with surgery can achieve a good local control in patients with negative but clinically close margins of resection. In patients with gross residual disease who are at a high risk for local recurrence, approximately one‐half can be locally controlled with this approach. These preliminary results should be tested in a prospective controlled study.
Pancreatic somatostatinoma: A case report and review of the literature
Authors: Konomi Kohki , Chijiiwa Kazuo , Katsuta Toshiro , Yamaguchi Kohji 
Published: February 2007

AbstractA 56‐year‐old man underwent distal pancreatectomy, splenectomy, and partial resection of the splenic flexure of the colon because of tumor in the tail of pancreas and the splenic hilus. The patient presented with symptoms of general malaise, anorexia, weight loss, mild diarrhea, and borderline diabetes mellitus, although there was no cholelithiasis. The diagnosis remained unclear until immunohistochemical studies of the resected specimen revealed somatostatin and synaptophysin, suggesting a somatostatinoma. Twenty‐three reported cases of pancreatic somatostatinoma are reviewed and their clinical features discussed. The role of immunohistochemical studies in the diagnosis of somatostatinoma is described.
Fine‐needle aspiration cytology of abdominal masses
Authors: Khanna Ajay Kumar , Misra Mahendra Kumar , Khanna Anuradha , Misra Vijay Kumar , Khanna Sushila 
Published: February 2007

AbstractAn investigation of the role of blind fine‐needle aspiration cytology (FNAC) in the assessment of palpable abdominal masses was carried out on 196 patients: 124 hepatic, 30 retroperitoneal, and 42 other masses. All of the smears were stained either by Papanicolaou stain or by hematoxylin and eosin stain. The results of FNAC were confirmed by further investigations in all cases. FNAC correctly diagnosed 166 (84.6%) cases. Twenty (10.2%) reports were false negative, and 10 (5.1%) smears were unsatisfactory for any diagnosis. Of 124 hepatic masses, the correct diagnosis was obtained in 106 (85.4%), false‐negative reports in 14 (11.2%), and unsatisfactory smears in 4 (3.2%). There were no false‐positive reports. For all of the lesions, the sensitivity of FNAC was 87.8%; specificity, 100%; positive predictive value, 100%; and negative predictive value, 52.4%. Five (2.5%) patients had considerable pain after the procedure.
Somatostatin analogue and tissue cultures in the study of a human malignant glucagonoma
Authors: Ahlman Håkan , Åhlund Lars , Dahlström Annica , Grimelius Lars , Theodorsson Elvar 
Published: February 2007

AbstractA patient with metastasizing glucagonoma producing multiple molecular forms of glucagon is reported. The patient responded to symptomatic treatment with a somatostatin analogue (SMS 201–995). Glucagonoma tumour cells were studied in two tissue culture systems: intraocular transplants of immunosuppressed rats and long‐term cell cultures. In both systems, several region‐specific glucagon antisera gave a positive immunoreaction with tumour cells indicating synthesis of multiple molecular species. Intraocular tumour transplants released glucagon into the chamber fluid. In animals with unilateral transplants, glucagon was also detected in the contralateral eye chamber, indicating passage from the transplants via unknown mechanisms. Treatment of tumour cells during culture with SMS 201–995 inhibited rapidly the spontaneous release of glucagon without evident cytotoxic effects. The inhibitory effect decreased with time.
Pdn‐21: Possible tumor marker for medullary thyroid carcinoma
Authors: Takami Hiroshi , Shikata Jun‐Ichi , Horie Hitoshi , Sekine Kyouichi , Ito Kunihiko 
Published: February 2007

AbstractThe plasma level of PDN‐21 was measured by RIA in 10 patients with medullary thyroid carcinoma (MTC). All 10 patients with MTC had extremely elevated PDN‐21 levels. The correlations between PDN‐21, calcitonin gene‐related peptide, and calcitonin, (all of which are calcitonin gene products) were significant (P < .001) in the 10 MTC patients. This study suggests that PDN‐21, as well as calcitonin, may be a useful marker for the detection of patients with MTC.
Expression of Lewisa, Lewisb, and sialated Lewisa antigens in early and advanced human gastric cancers
Authors: Inagaki Hiroshi , Sakamoto Junichi , Nakazato Hiroaki , Bishop Anne E. , Yura Jiro 
Published: February 2007

AbstractAn immunohistochemical analysis of the expression of Lewisa, Lewisb, and sialated Lewisa blood group antigens was performed on specimens of human non‐involved stomach (n = 91), early gastric cancers (n = 41), and advanced gastric cancers (n = 50). In non‐involved stomach, Lewisa and Lewisb were detected mainly in surface epithelium, although sialated Lewisa was scarcely expressed. These blood group‐related antigens were rarely observed in deep glands. In gastric cancers, Lewisa showed a tendency to be expressed in well or moderately differentiated carcinomas, and this was observed to be more marked in advanced tumors. There was no obvious difference in positive ratios of Lewisb between degrees of differentiation of the cancers. Sialated Lewisa was not detected in early cancers, and its frequent expression in well‐ or moderately differentiated, advanced carcinomas suggested an association with both cancer differentiation and progression. These results indicate that knowledge of the expression of blood group antigens may help interpret the antigenic alterations occurring in the course of carcinogenesis, differentiation, and progression of gastric cancers.
Fine needle aspiration biopsy in clinical management of head and neck tumors
Authors: Flynn Michael B. , Wolfson Stewart E. , Thomas Steven , Kuhns James G. 
Published: February 2007

AbstractNinety‐five percent (195) of 203 fine needle aspiration biopsies (FNAB) of head and neck specimens contained adequate tissues for histologic evaluation. No complications or needle tract recurrences were identified. Out of 135 patients whose surgical excision followed FNAB, 5% (7/135) of the biopsies were nondiagnostic. Correlation of cytologic and histologic findings of the remaining 128 FNAB revealed a sensitivity rate of 82% (46/56), a specifity rate of 99% (71/72), and a positive predictive of value of 98% (46/47). The diagnostic accuracy of FNAB was better with salivary gland and cervical node specimens than with thyroid, skin, and subcutaneous specimens. Fine needle aspiration biopsy may be considered as the first diagnostic step in the evaluation of the mass of the head and neck region, if the nondiagnostic aspiration rate is low and the diagnostic accuracy is high.
Adenocarcinoma of the vermiform appendix
Authors: Harris Gary J. , Urdaneta Luis F. , Mitros Frank A. 
Published: February 2007

AbstractPrimary adenocarcinoma of the appendix is rare. Eleven patients with this rare neoplasm have been evaluated at our institution over a 50‐year period. We have reviewed the presentation and clinical course of these patients, and have compared them with those described in the literature. The presenting signs and symptoms, physical findings, and treatment were similar to those described in the literature. However, the 5‐year survival of 20% is lower than most series, and reflects the advanced stage of disease at the time of diagnosis in this group of patients. Despite the low 5‐year survival, we feel that aggressive therapy (right hemicolectomy) is necessary to obtain long‐term survival.
Establishment of an esophageal squamous cell carcinoma tumor line and development of serum squamous cell carcinoma‐related antigen in athymic nude mice
Authors: Terashima Masanori , Ikeda Kenichiro , Ishida Kaoru , Saito Kazuyoshi 
Published: February 2007

AbstractA serially transplantable tumor line (IMEs‐1) derived from human esoph‐ageal squamous cell carcinoma (SCC) of a 71‐year‐old female was established in nude mice. The histology of IMEs‐1 closely resembled that of the original tumor and tumor doubling time was 3.2 days. Production of SCC‐related antigen (SCCRA) and carcinoembrionic antigen (CEA) in the serum of tumor‐bearing mice was observed.To evaluate the usefulness of SCCRA for esophageal cancer, the relationship between the serum levels of SCCRA and tumor burden in athymic nude mice bearing IMEs‐1 was studied.The mean serum levels of SCCRA, as determined by radioimmunoassay, gradually rose in direct proportion to the tumor growth gauged by tumor volume.However, the serum levels of CEA did not increase until the last few weeks of the assay. These results suggest the possibility of using SCCRA as a tumor marker for esophageal SCC. In addition, this nude mouse assay system will provide a theoretical model to study the usefulness of SCCRA.
Characterization of four newly established human colorectal adenocarcinoma cell lines from chinese patients
Authors: Cheng Jhy‐Young , Meng Ching‐Liang , Lin Iih‐Chang , Tzeng Ching‐Cherng , Chin Li‐Te , Shen Kuo‐Liang 
Published: February 2007

AbstractFour colon adenocarcinoma cell lines, CC‐M2, CC‐M3, CC‐M4, and CC‐M2NM, have been established from surgical specimens of 18 unselected patients without the use of “feeder” cells and additional growth factors (e.g., insulin, hydrocortisone, etc.) in the culture medium. The methods of primary cultivation of tissue explants are described. Studies of determination of morphology, growth curve, plating efficiency, chromosomal analysis, CEA and beta‐HCG synthesis, and tumorigenicity, were done to characterize the cell lines. Significant variations have been found in one of the four cell lines, both in vitro and in vivo studies. There are distinct phenotypes in the established cell lines which may be useful in studying the cell differentiation and progression of colorectal cancer.
Changes in the DNA ploidy patterns of human colorectal carcinomas, subsequent to culture or xenografting
Authors: McA. Foster Hamish , Tay Diana L. M. , Whitehead Robert H. 
Published: February 2007

AbstractDNA ploidy patterns were measured by flow cytometry in 7 human carcinomas and compared with the DNA histograms of 3 cell lines and 25 xenografts and derived from them. Four of the carcinomas showed DNA ploidy changes on initial xenografting or early passaging, while 2 carcinomas showed stable ploidy patterns over several xenograft passages. One xenograft derived from a cell line showed a marked, but stable, increase in DNA content over the original human carcinoma. Two of the 3 cell lines were DNA aneuploid, and at least 1 line was apparently derived from a minor subpopulation in the original carcinoma. The possible mechanisms and implications of these changes are discussed.
Cyclophosphamide and ifosfamide combination as neoadjuvant chemotherapy for locally advanced nonsmall‐cell lung cancer: A meta‐analytic review
Authors: Rosell Rafael , Moreno Isabel , Maestre José , Olazabal Angel , Carles Joan , Barnadas Augustin , Abad‐Esteve Albert , Ribelles Nuria , Canela Mercedes 
Published: February 2007

AbstractTwenty‐three patients with marginally resectable and unresectable nonsmall‐cell lung cancer (stages IIIA and IIIB) were treated by neoadjuvant chemotherapy. All patients received three cycles of preoperative chemotherapy with two alkylating agents, cyclophosphamide 2.5 g/m2 intravenously (i.v.) and ifosfamide 3.5 g/m2 i.v., mesna 12 g/m2 was given additionally to prevent drug hematuria. Six of 23 patients (26%) had partial response. Of the seven patients who underwent thoracotomy, two were completely resected, but with macroscopic residual disease. Mean time to progression for the whole group was 7 months. Fifteen patients had progression of disease, with local metastases only in six, and distant metastases in eight. After administering 52 chemotherapy cycles, cyclophosphamide‐ifosfamide doses were cut down, as eight of 16 patients required hospitalization for fever during neutropenia nadirs. This two‐ alkylating (non‐cisplatin) regimen, unlike cisplatin‐based regimens, was ineffective, and further trials are not recommended.
Adjuvant chemotherapy enhances long‐term survival of patients with advanced gastric cancer following curative resection
Authors: Maehara Yoshihiko , Moriguchi Sunao , Sakaguchi Yoshihisa , Emi Yasunori , Kohnoe Shunji , Tsujitani Shunichi , Sugimachi Keizo 
Published: February 2007

AbstractWe examined the effectiveness of postoperative adjuvant chemotherapy with mitomycin C (MMC), 1‐(2‐tetrahydrofuryl)‐5‐fluorouracil (tegafur), plus PSK, an immunomodulator, for patients with advanced gastric cancer who underwent histological curative resection. The effect of chemotherapy on prognostic serosal (ps) invasion [ps(−) or ps(+)] and lymph node metastasis [n(−) or n(+)] was examined. One hundred eighteen patients were in the no‐chemotherapy group and 137 were on the drugs. The median follow‐up time for the 86 survivors at the time of analysis was 13.8 years. With regard to prognostic factors, there were no differences between the two groups. Generalized Wilcoxon test of the two survival patterns revealed a P value of .0351, and the survival rate for 15 years was 45.7% for patients in the no‐chemotherapy group and 56.9% for those of the chemotherapy group. In particular, adjuvant chemotherapy was effective for patients with ps(−)n(+) (P <.05) and ps(+)n(−) ( P <.05), but not for those with ps(−)n(−) and ps(+)n(+).Our findings show that the concomitant prescription of MMC, tegafur, and PSK improves the 15‐year survival rate for patients with advanced gastric cancer, following curative resection. As the survival rate is low for the patients with ps(+)n(+), an even more aggressive postoperative chemotherapy is recommended.
Complications of stapled anastomoses in anterior resection for rectal carcinoma: Colorectal anastomosis versus coloanal anastomosis
Authors: Burke Emmett R. C. , Welvaart Kees 
Published: February 2007

AbstractPostoperative results of 48 patients who underwent anterior resection using the EEA‐stapler were evaluated. In all but 2 cases the indication for surgery was colorectal carcinoma. In 24 patients an anastomosis was created above the 5 cm level (above the anal verge: colorectal anastomosis) and in 24 at the 0‐5 cm level (coloanal anastomosis). There was no perioperative mortality. The only complication observed in the colorectal anastomosis group was one case of late anastomotic stenosis. In the coloanal anastomosis group there were 4 cases with early anastomosis leaks, 3 cases with late stenosis and 5 cases with various degrees of late fecal incontinence, ultimately resulting in a permanent diverting stoma in 5 (10.4%) patients.We conclude that for rectal tumors the EEA‐stapled anterior resection provides excellent functional results in most cases. Stapled coloanal anastomoses more often demonstrate various (early and late) complications. Nevertheless in spite of chronic discomfort, many patients still prefer their complaints to a permanent stoma.
Immune‐competent cells of regional lymph nodes in colorectal cancer patients: II. Immunohistochemical analysis of leu‐7+ cells
Authors: Adachi Wataru , Usuda Nobuteru , Sugenoya Akira , Iida Futoshi 
Published: February 2007

AbstractDistribution of Leu‐7+ cells in cancer tissues and regional lymph nodes was immunohistochemically examined to estimate the role of NK cells in colorectal cancer patients. Leu‐7+ cells were rarely observed both in the primary and distant metastatic lesions, but the number of these cells was large in the germinal center of the lymph nodes. Studies of Leu‐7+ cell population in the lymph node indicated that intermediate nodes in n0 and n1 groups showed significantly higher values than those in the control group. Comparative study of the population in identical patients revealed a significantly higher rate in the intermediate nodes than in the paracolic nodes both in n0 and n1 groups.These data suggest that Leu‐7+ cells might be related to the defense mechanism of regional lymph nodes against tumor.
Long survival and prognostic factors in hepatocellular carcinoma
Authors: Zhao Guolong , Su Suey , Borek Deborah , Friesen Stanley , Holmes Frederick 
Published: February 2007

AbstractWe studied survival and prognostic factors in all cases of hepatocellular carcinoma seen at a Midwestern teaching hospital from 1947 through 1986. Of the 70 cases, 56 were diagnosed during life and 14 at autopsy. There were 47 males and 23 females with age at diagnosis ranging from 14 to 88. Median survival for the 56 patients diagnosed during life was 106 days. Only 11 patients lived longer than one year. Two patients were long survivors and presumed cured, one living 27 years after diagnosis and surgical treatment and the other 19 years. Cox regression model showed young age at diagnosis and low stage of disease at diagnosis to be significant predictors of long survival. White patients survived nearly twice as long as black patients but the difference was not significant. Gender and year of diagnosis did not appear to be important determinants of survival. Pathologic material was still available for one of the two long survivors and the histology was that of fibrolamellar carcinoma of young adults.