bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative endoscopic study of primary gastric lymphoma vs. gastric carcinoma
Authors: Swaroop V. Santhi , Mohandas K. M. , Swaroop V. Durga , Soman C. S. , Krishnamurthi S. , Nagral Aabha , Jagannath P. , Desouza L. J. 
Published: February 2007

AbstractThe endoscopic records of 56 patients with primary gastric lymphoma and 120 patients with gastric adenocarcinoma (matched for age and sex) were compared with respect to site, extent, and type of tumor by endoscopy and biopsy results. Diagnosis of lymphoma was suspected on the basis of gross endoscopic appearance in 30 patients with 96% sensitivity. The endoscopic findings that achieved statistical significance in favor of lymphoma were extensive disease involving whole stomach, proximal stomach involvement, extension of tumor into duodenum, and the presence of volcano crater‐like ulcers on polypoid lesions. Endoscopic biopsies were positive for lymphoma in 92% patients. Immunoperoxidase staining for leucocyte common antigen was positive in all the 24 patients with lymphoma where it was performed. We conclude that lymphoid origin of the stomach tumor may be suspected in one‐half of the cases of primary gastric lymphoma by gross endoscopic findings. Multiple endoscopic biopsies are safe and highly sensitive and specific in the diagnosis of primary gastric lymphoma. © 1994 Wiley‐Liss, Inc.
Regional chemotherapy in the canine liver
Authors: Zografos George C. , Kanter Peter , Sharma Satya D. , Driscoll Deborah L. , Blumenson Leslie E. , Karakousis Constantine P. 
Published: February 2007

AbstractUsing a fluorometric assay, mean drug levels of Adriamycin were significantly higher in the normal canine liver following bolus injection of this drug via the hepatic artery or portal vein as compared to hepatic tissue levels following systemic intravenous administration (P < 0.001). However, the variations in tissue levels observed after hepatic artery (± 16.8 mcg/gm tissue) or portal vein (± 21.1 mcg/gm) infusion were significantly wider than those observed after systemic (± 1.3 mcg/gm) administration (P = 0.03). Using C14‐labeled drugs, regional infusion of Adriamycin through the hepatic artery or portal vein resulted in significantly higher mean drug levels in the liver than after systemic intravenous administration, but the difference was more pronounced with bolus infusion of the drug than 1‐hour infusion. 5‐FU bolus or 1‐hour infusion in the hepatic artery resulted in significantly higher mean drug levels in the liver compared to peripheral intravenous administration, but this was not so with the 3‐hour infusion.The above experiments confirm previous studies that regional chemotherapy results in higher drug levels in the regional tissues compared to systemic administration. They also: (1) demonstrate the spotty drug distribution in the regional tissues after regional administration, a potentially correctable problem, and (2) suggest that the advantage of intra‐arterial infusion may be more pronounced within a certain range of infusion times. © 1994 Wiley‐Liss, Inc.
Esophageal carcinoma simultaneously associated with gastric carcinoma: Analysis of clinicopathologic features and treatments
Authors: Kato Hoichi , Tachimori Yuji , Watanabe Hiroshi , Mizobouchi Shunji , Igaki Hiroyasu , Yamaguchi Hajime , Ochiai Atsushi 
Published: February 2007

AbstractAmong 1,420 patients with throacic esophageal carcinoma, 85 (6.1%) had synchronous gastric carcinoma. Seventy‐two patients (84.7%) underwent esophagectomy. Their operative mortality and prognosis were similar to those without gastric carcinoma. Among them, 25 patients, of whom the majority had advanced gastric carcinoma, underwent transthoracic esophagectomy with total gastrectomy (group A); eight died of esophageal cancer and four of gastric cancer. Forty‐six patients, of whom the majority had gastric carcinoma in an early stage, underwent esophagectomy and esophagogastric anastomosis following partial gastrectomy or local treatment for gastric carcinoma (group B). None of the group B patients had recurrent gastric carcinoma. The operative burden was larger in group A. The 5‐year survival rate for groups A and B were 38.8% and 23.0%, respectively. Esophagectomy and esophagogastric anastomosis after limited treatment for gastric carcinoma is an adequate treatment for the majority. However, esophagectomy and total gastrectomy are recommended for patients with advanced gastric carcinoma. © 1994 Wiley‐Liss, Inc.
Effect of the combination of hyperthermia and irradiation on human colon cancer cells
Authors: Tur Gennady E. , Sato Yasuhiko , Fukuoka Takemi , Andoh Hideaki , Kotanagi Hitoshi , Koyama Kenji 
Published: February 2007

AbstractThe combination of hyperthermia and radiation is considered to have a synergistic effect on mammalian cells, which depends on temperature and duration of time of the hyperthermia and on the sequence in which the modalities are given. The response of cultured colon cancer cells to hyperthermia and ionizing radiation was evaluated using the flow cytometry method by measuring DNA damage. The enhanced DNA damage after combined treatment with hyperthermia and irradiation was recognized after both sequences: heat followed by radiation as well as radiation followed by heat. The results demonstrated that the sequence of radiation plus heat produced more DNA damage on colon cancer cells than did the reverse order. The clinical application of these results is discussed. © 1994 Wiley‐Liss, Inc.
Munchausen's syndrome and cancer
Authors: Bruns Alan D. , Fishkin Paul A. , Johnson Eric A. , Lee Yeu‐Tsu Margaret 
Published: February 2007

AbstractMunchausen's syndrome is a chronic factitious disorder characterized by frequent hospitalizations, self‐inflicted injuries, and dramatic medical histories. People with this condition assume the role of a sick patient and submit to unnecessary invasive, painful, and even dangerous medical procedures. In review of the literature, there have been four reports of patients feigning oncological disease. We admitted a 27‐year‐old woman who had undergone operative insertion of a Port‐A‐Cath and multiagent chemotherapy for “advanced ovarian cancer.” Physicians should be aware of Munchausen's syndrome in order to avoid costly medical procedures and unnecessary operations and to stop the patient's vicious circle of pathological lying and self‐inflicted injury. © 1994 Wiley‐Liss, Inc.
Flow cytometry of liver fine needle aspirates
Authors: Fuhr Joseph E. , Kattine Anthony A. , Nelson H. Sperry 
Published: February 2007

AbstractFine needle aspiration analysis of intraabdominal masses is increasing in frequency. This study was designed to evaluate whether flow cytometry could be of value in the cytopathology interpretation of such specimens. Over a 4‐year time span, 129 consecutive liver fine needle aspirates were evaluated by flow cytometry for DNA content, ploidy, and proliferation rate. Only excess cells remaining in the needle after cytology samples were prepared were included in this study. Overall sensitivity was 75% and specificity was 94%. In addition, flow cytometry results were pivotal for at least two specimens in achieving the appropriate diagnosis. For these reasons, it was concluded that flow cytometry could be a valuable adjunctive technology to the cytopathologist in the interpretation of liver fine needle aspirates. © 1994 Wiley‐Liss, Inc.
Surgical treatment of pulmonary metastases from soft tissue sarcomas: A retrospective study in the Netherlands
Authors: van Ceel Albert N. , Van Coevorden Frits , Blankensteijn Jan D. , Hoekstra Harald J. , Schuurman Bart , Bruccink Erik D. M. , Taat Carlo W. , Theunissen Evert B. M. 
Published: February 2007

AbstractSixty‐seven of 87 patients with soft tissue sarcoma underwent complete resection of the metastases in the lung. In this retrospective study, follow‐up was for a median of 24 months. The 5‐year overall, crude, and disease‐free survival was 38%, 45%, and 41%, respectively. Twentyseven (40%) patients developed a recurrence in the lung. Of the six prognostic variables, the only factor significantly related to disease‐free survival was grade. It is concluded that surgery for lung metastases of soft tissue sarcoma should be considered as standard therapy when preoperative evaluation predicts a complete resection. By adding chemotherapy to surgery, an improvement of prognosis probably can be achieved. © 1994 Wiley‐Liss, Inc.
Effect of trauma of implantation of metastatic tumor in bone in mice
Authors: Lee Jin Yong , Murphy Satya M. , Scanlon Edward F. 
Published: February 2007

AbstractWe studied the influence of surgical trauma to the iliac bone on the implantation of I. V. injected tumor cells, which formed tumor in the surgical wounds of 27/84 mice (32%). None of these mice or nonsurgical mice developed tumor in the opposite or uninjured pelvic bone (P < 0.0001). When different numbers (105, 5 × 105, and 10 × 105) of TA3Ha cells were injected I. V. immediately after surgery, the frequency of tumor formation showed an increase (respectively, 32%, 63%, 71%). As the interval between induction of trauma and tumor cell injection was increased from 0 to 15 days, the frequency of tumor formation declined from 32% to 0%. These results suggest that the healing wound is a privileged site for experimental metastasis, particularly in the early stages. It is likely that the proteins in the blood clotting cascade are involved in local tumor implantation. © 1994 Wiley‐Liss, Inc.
Malignant germ cell tumors in childhood
Authors: Nair Reena , Pai Suresh K. , Saikia Tapan K. , Nair Chandrika N. , Kurkure Purna A. , Gopal Ramakrishnan , Sampat Mridula S. , Advani Suresh H. 
Published: February 2007

AbstractThe outlook for patients with germ cell tumors was poor before the advent of effective chemotherapy. In this study the outcome of multiagent chemotherapy in children treated for germ cell tumor is assessed. Between January 1984 and December 1990, 107 patients were diagnosed to have germ cell tumors. Postsurgical therapy was based on tumor site, stage, and histology. Combination chemotherapy was employed in patients with Stages I and II disease with postoperative raised tumor markers and all patients with Stages III and IV. Between 1984–1988, patients received cisplatin, vinblastin, bleomycin, and methotrexate (PVB‐M), and thereafter between 1988–1990, they received bleomycin, etoposide, and cisplatin (BEP). Of 34 patients treated with PVB‐M and 27 treated with BEP, the complete remission rate was 40% and 85%, respectively, and the overall survival was 30% at 5 years for PVB‐M and 80% at 3 years for BEP. We conclude that etoposide with cisplatin is superior to vinblastin with cisplatin in the treatment of advanced germ cell tumors because of greater efficacy, decreased toxicity, and better compliance in children. © 1994 Wiley‐Liss, Inc.
Neurilemmoma of the diaphragm
Authors: Urschel John D. , Antkowiak Joseph G. , Takita Hiroshi 
Published: February 2007

AbstractDiaphragmatic neurilemmomas are rare tumors. We report here such a case and also review five cases from the English‐language medical literature. Neurilemmomas of the diaphragm are benign tumors that display slow, progressive growth. They remain encapsulated and do not invade adjacent structures. Surgical resection is both diagnostic and therapeutic. Thoracotomy is the operative approach of choice. © 1994 Wiley‐Liss, Inc.
Antibody response correlates with septic complications following esophagectomy for cancer
Authors: Kinoshita Tadahiko , Saito Takao , Shigemitsu Yuji , Katsuta Takeshi , Kobayashi Michio 
Published: February 2007

AbstractCorrelations between preoperative antibody response and postoperative septic complications were examined in patients with esophageal cancer. Thirty‐three patients and 9 age‐matched controls were immunized with 23‐valent pneumococcal polysaccharide (PPS) vaccine, and serum anti‐PPS IgG, IgA, and IgM were measured. Of 28 patients undergoing transthoracic esophagectomy, 9 had postoperative septic complications (SCP) and 19 did not (SCN). Median titers of anti‐PPS IgG‐producing capacity were 158 ELISA units (EU) (interquartile range, 71‐1,862 EU) in the SCP group and 1,349 EU (interquartile range, 741‐2,95 1 EU) in the SCN group (P = 0.01). No significant differences in anti‐PPS IgA and IgM were found between the two groups. These results indicated that low antibody response to polysaccharides is associated with the occurrence of postoperative septic complications in patients with esophageal cancer. Thus, a preoperative evaluation of antibody‐producing capacity may serve to predict these complications. © 1994 Wiley‐Liss, Inc.
Flow cytometry as a prognostic predictor in gastric linitis plastica
Authors: Candel Al , Green Linda , Castelli Melanie , Abraham Kurian , Aranga Gerard , Gattuso Paolo 
Published: February 2007

AbstractGastric linitis plastica (GLP) is a diffusely infiltrating carcinoma of the stomach that is usually diagnosed in an advanced stage and associated with poor prognosis. Recent studies to evaluate ploidy of these tumors are not conclusive. We undertook a retrospective study of 43 surgically treated patients with GLP (27 males, 16 females, mean age 65 years) to see if ploidy could be used to predict outcome. Flow cytometric DNA analysis was performed on paraffin‐embedded tissue using the modified Hedley technique. Mean follow‐up interval was 11 months (1–72 months) with 18 (42%) alive at end of study. The remaining 25 (58%) died with a mean survival of 7 months. Lymph node status was positive in 31 (70%) and negative in 12 (30%) of patients. Twenty‐nine (67%) of tumors were diploid; 14 (33%) were aneuploid. Statistical analysis revealed overall surcvival correlated significantly (P = 0.04) only with lymph node status. Diploid tumors had 18 (60%) positive and 11 (40%) negative lymph nodes, whereas aneuploid tumors had 13 (93%) positive and 1 (7%) negative nodes. DNA content correlated significantly (P = 0.05) with lymph node status, but not with overall survival. Tumors with positive lymph nodes were 18 (51%) diploid and 13 (42%) aneuploid; tumors with negative nodes were 11 (92%) diploid and 1 (8%) aneuploid. Conclusions: The majority of GLP tumors manifest diploid characteristics, and the presence or absence of lymph node metastasis is a major determinant in overall survival. © 1994 Wiley‐Liss, Inc.
Randomized trial comparing postoperative chemotherapy with vindesine and cisplatin plus thoracic irradiation with irradiation alone in stage III (N2) non‐small cell lung cancer
Authors: Pisters K. M. W. , Kris M. G. , Gralla R. J. , Hilaris B. , McCormack P. M. , Bains M. S. , Martini N. 
Published: February 2007

AbstractThis prospective randomized trial was performed to determine whether postoperative chemotherapy with vindesine and cisplatin could lengthen time to progression and overall survival in stage III (T1‐3N2MO) non‐small cell lung cancer (NSCLC) patients. Seventy‐two patients were entered; 36 were randomized to receive chemotherapy. Patients were stratified by extent of resection (complete vs. incomplete) and histology (squamous vs. nonsquamous). All had surgery and mediastinal irradiation 6–7 weeks post‐thoracotomy. Incompletely resected patients had intraoperative 125I and/or 192Ir implantation. Vindesine (3 mg/m2) weekly × 5, then every 2 weeks × 8, and cisplatin (120 mg/m2) days 1, 29, 71, 113 were planned for those randomized to chemotherapy. No difference in time to progression (median 9.2 months for radiation + chemotherapy vs. 9.0 months for radiation, P = 0.35) or overall survival (16.3 months for radiation + chemotherapy vs. 19.1 months for radiation, P = 0.42) was found. Postoperative vindesine and cisplatin did not prolong time to progression or survival in this population of stage III NSCLC. © 1994 Wiley‐Liss, Inc.
Synergistic antitumor activity of combination chemotherapy with mitomycin C and cisplatin against human gastric cancer xenografts in nude mice
Authors: Saikawa Yoshiro , Kubota Tetsuro , Kuo Tsong‐Hong , Furukawa Toshiharu , Kase Suguru , Tanino Hirokazu , Isobe Yo , Watanabe Masahiko , Ishibiki Kyuya , Arimori Masaki , Kitajima Masaki 
Published: February 2007

AbstractA new combined cancer chemotherapy regimen of mitomycin C (MMC) and cisplatin (DDP) showed synergistic antitumor activity against human gastric cancer xenografts St‐40 and SC‐1‐NU in BALB/c nu/nu mice. The drugs were administered intraperitoneally at doses of 2 or 4 mg/kg for MMC and 3 or 6 mg/kg for DDP, respectively. To clarify the schedule‐dependent antitumor activity of MMC and DDP against St‐40 and SC‐1‐NU, different sequential therapies were conducted. Simultaneous administration of these agents showed the highest antitumor activity against SC1‐NU among the three regimens used, whereas the sequence of MMC followed by DDP showed higher antitumor activity than the reverse sequence against St‐40. The intratumoral concentration of platinum was significantly increased in St‐40 treated with the sequence MMC to DDP, in comparison with the sequence DDP to MMC. The maximum tolerated dose (MTD) of this combination was 4 mg MMC plus 6 mg DDP per kg in all the combinations, and these MTDs were 2/3 of the corresponding values for their single use. Since this combination increased the antitumor activity of each single agent without any increase in their toxicity, it would appear to be useful clinically. © 1994 Wiley‐Liss, Inc.
Effect of cholecystokinin analogue caerulein and cholecystokinin antagonist lorglumide on pancreatic carcinogenesis in the rat
Authors: Sperti Cosimo , Militello Carmelo , Behboo Roubik , Khajeturian Edwin , Pedrazzoli Sergio , Perasole Antonio , Alaggio Rita , Rovati Lucio 
Published: February 2007

AbstractThe effects of the cholecystokinin (CCK)‐analogue, caerulein, and CCK‐receptor antagonist lorglumide (CR‐1409) on pancreatic carcinogenesis induced by 7,12‐dimethylbenz(a)anthracene (DMBA) were studied. One hundred thirty rats were divided into the following 10 treatment groups: group 1, DMBA (2–3 mg); group 2, DMBA + caerulein (5 μg/kg); group 3, DMBA + caerulein + CR‐1409 (12 mg/kg); group 4, caerulein + DMBA; group 5, caerulein + CR‐1409 + DMBA; group 6, DMBA + CR‐1409; group 7, CR‐1409 + DMBA; group 8, caerulein; group 9, CR‐1409; and group 10, sham operation + saline. DMBA was surgically implanted into the pancreas. Caerulein and/or CR‐1409 was administered twice daily for 15 days after (in groups 2, 3, and 6) or before (in groups 4, 5, and 7) DMBA implantation. Six months after carcinogen administration, all rats were sacrificed and autopsied. The incidence of pancreatic cancer appeared significantly (P < 0.001) increased when caerulein was administered following DMBA implantation. CR‐1409 significantly inhibited (P < 0.02) caerulein effects and reduced tumor growth when injected after carcinogen exposure. © 1994 Wiley‐Liss, inc.
Univariate and multivariate analyses of the prognostic significance of discontinuous intramural metastasis in patients with esophageal cancer
Authors: Kuwano Hiroyuki , Watanabe Masayuki , Sadanaga Noriaki , Kamakura Tatsuro , Nozoe Tadahiro , Yasuda Mitsuhiro , Mimori Koshi , Mori Masaki , Sugimachi Keizo 
Published: February 2007

AbstractA review of 167 cases of esophageal carcinoma without preoperative treatment revealed 24 (14.4%) to have intramural metastasis (IM) within the esophagus. Among the clinicopathologic factors, the length of the lesions (P< 0.01), lymph node metastasis (P< 0.001), and the depth of the invasion of the tumor (P< 0.0001) were found to be statistically significant different factors between the two groups of patients both with and without intramural metastasis. The survival curve for patients with IM was significantly lower than that for patients without IM (P< 0.0001). A univariate analysis revealed that the depth of invasion, lymph node metastasis, IM (P< 0.0001), and the length of the lesion (P< 0.001) all had a significant correlation with the prognosis. Moreover, in a multivariate analysis, the depth of the invasion (<0.001), length of the lesion (0.001), and IM (0.049) were all determined to be significant prognostic factors. Therefore, IM is considered to be one of the independent significant prognostic factors for predicting a poor prognosis in esophageal cancer. © 1994 Wiley‐Liss, Inc.
Circadian rhythm modulated 5‐FUdR infusion with megace in the treatment of advanced pancreatic cancer
Authors: de W. Marsh Robert , Manyam Vani , Bewsher Carol , Youngblood Margaret 
Published: February 2007

AbstractThirteen patients with advanced pancreatic carcinoma were treated with circadian rhythm modulated infusion of 5‐FUdR and Megace. Treatment was initiated at a dose of 0.15 mg/kg/day for 14 days every 28 days and was increased or decreased by 0.025 mg/kg/day with each subsequent cycle until maximum tolerated dose (MTD) was achieved. Megace (200 mg) was administered daily in divided doses. One‐third of the patients were able to complete ⩾6 cycles of treatment, one‐half could only complete ⩽2 cycles, and the remainder managed 3–4 cycles. No patients had regression of disease, but a small number, who were able to receive 6–7 months of treatment, achieved stable disease in the short term. In conclusion, treatment was fairly well tolerated. However, increased dose intensity by this method did not significantly increase response rate. In only a few patients was disease stabilized for a brief period. Megace did not materially improve nutritional status. CA‐19‐9 levels did not correlate well with disease activity. © 1994 Wiley‐Liss, Inc.
Pleural dissemination in non‐small cell lung cancer: Results of radiological evaluation and surgical treatment
Authors: Akaogi Eiichi , Mitsui Kiyofumi , Onizuka Masataka , Ishikawa Shigemi , Tsukada Hiroshi , Mitsui Toshio 
Published: February 2007

AbstractThe aims of this study are to evaluate the diagnostic ability of chest computed tomography (CT) in the early detection of pleural disease and to analyze the results of surgical treatment for lung cancer with pleural dissemination. Twenty‐three non‐small cell lung cancer patients with pleural dissemination, but without distant metastasis, underwent pleuropulmonary resection during the past 15 years. Chest CT scans were obtained preoperatively in 21 of those patients. In eight patients without pleural effusion, small pleural nodules, about 3–5 mm in size, were found in their chest CT. However, during surgery, small nodules were more frequently observed on the parietal pleura than on the visceral pleura in five of them. Therefore, early detection of the dissemination by chest CT seemed limited to only those of the visceral pleura. In the survival curve after resection, there was no difference among the patients with n2 disease, but there was a significant difference between the patients without n2 disease and those with it (P < 0.05). The presence of n2 disease appeared to be a poor prognostic sign in this form of advanced lung cancer. © 1994 Wiley‐Liss, Inc.