bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes of Patients with Heavily Pretreated Relapsed/Refractory Multiple Myeloma Receiving Salvage Cytotoxic Therapy with Supportive Stem Cell Boost
Authors: Bangolo Ayrton , Oza Samir , Reich-Slotky Ronit , Chappell Aimee , Siegel David S. , Parmar Harsh , Biran Noa , Vesole David H. , Phull Pooja 
Published: April 2024

Background:
Multiple myeloma (MM) is an incurable hematologic malignancy characterized
by the neoplastic proliferation of plasma cells, which produce monoclonal immunoglobulin
that can cause vital organ damage, subsequently leading to significant morbidity and mortality.
Autologous hematopoietic stem cell transplant (ASCT) is the standard-of-care management of eligible
patients with newly diagnosed MM. Experts recommend collecting enough stem cells upfront
to support a possible tandem transplant, salvage ASCT, or a stem cell “boost” to allow for
the administration of multiagent cytotoxic chemotherapy in patients with relapsed/refractory disease.

Objective:
There is currently a paucity of data on the response rates and outcomes of patients with
relapsed MM who undergo cytotoxic chemotherapy followed by a stem cell boost; this study examines
the outcomes of patients treated with this approach.

Methods:
We conducted a retrospective chart review from two oncologic treatment centers in the
United States of adult patients who underwent a first ASCT between 1999 and 2021 and subsequently
received cytotoxic chemotherapy followed by stem cell boost further on in their disease
course. Survival analysis was carried out using the Kaplan-Meier method, and the log-rank test
was used to compare survival curves.

Results:
We found that the majority (56.6%) of these patients responded to therapy and that
60.6% of these patients were able to receive at least one subsequent line of therapy post-boost.
Furthermore, patients who responded to therapy had significantly longer median overall survival
compared to those who did not respond (323 days vs 93 days, p=0.0045), and age did not affect response
to therapy.

Conclusion:
This data allow clinicians to appropriately implement and inform patients of the therapeutic
uses and clinical outcomes of stem cell boost in patients with multiply relapsed/refractory
MM.
Response of Male Reproductive System against Ionizing Radiation and Available Radio-protective Agents: Cellular and Molecular Insight
Authors: Parashar Ronit , Yadav Sanwar Mal , Meena Priyadarshi , Kumar Raj , Jheeta Kuldeep S , Saini Priya , Patel Dev Dutt 
Published: April 2024

Background:
The reproductive organ, housing spermatogonial stem cells (SSCs),
undergoes ongoing division impacted by the irradiation dosage and exposure duration. Within
the male reproductive organ, germ stem cells (spermatogonia) and somatic cells (Sertoli and
Leydig cells) are present. Lower doses of ionizing (>4-6 Gy) and non-ionizing radiation (radiofrequency
and microwave range 900 MHz - 2.45 GHz) may cause sperm-related issues, while
higher doses (15 Gy) may affect Leydig cells and testosterone production. Response to radiation
varies with age and pubescence. Spermatogonial stem cells, crucial for regenerating the spermatogenic
lineage, express molecular markers like Estrogen receptor, FSH (Follicular Stimulating
Hormone) receptor, TLR-4 (Toll-like Receptor-4), TLR-5 (Toll-like Receptor-5), FGF2 (Fibroblast
Growth Factor-2), KIT (Receptor Tyrosine Kinase), AT-1 (Angiotensin II Type-1 Receptor),
LXRs-γ (Liver X Receptor-γ), TNF-β (Tumor Necrosis Factor-β), and PCNA (Proliferating
Cell Nuclear Antigen), influencing stem cell activity in testes.

Objective:
This study aimed to review the various available radioprotective agents and their efficacy
in targeting the male reproductive system from the available literature.

Result:
Various radioprotective herbal/synthetic/microbial/metallic extracts/formulations/
drugs [Septilin, Silymarin, Organic Turmeric, Oestrogen, Melatonin, Febuxostat, SQGD (Semiquinone
glucoside derivative), Rapamycin, Entolimod, Zinc, Selenium, etc.] have been investigated
up to exposure, but owing to effectiveness issues, they are unable to fulfil the aim to the
fullest of restoring male fertility and normal testosterone levels during such eventuality.

Conclusion:
Further study is needed to optimize these tactics and fill knowledge gaps. Also, the
effective components of herbal, synthetic drugs, etc., should be isolated and tested up to clinical
levels, paving the way for successful radioprotection and radiomitigation strategies in the male
reproductive system.
Epidemiological Characteristics of Varicella in Anhui Province, China, 2012-2021: Surveillance Study
Authors: Xuan Kun , Zhang Ning , Li Tao , Pang Xingya , Li Qingru , Zhao Tianming , Wang Binbing , Zha Zhenqiu , Tang Jihai 
Published: April 2024

Background
Varicella is a mild, self-limited disease caused by varicella-zoster virus (VZV) infection. Recently, the disease burden of varicella has been gradually increasing in China; however, the epidemiological characteristics of varicella have not been reported for Anhui Province.

Objective
The aim of this study was to analyze the epidemiology of varicella in Anhui from 2012 to 2021, which can provide a basis for the future study and formulation of varicella prevention and control policies in the province.

Methods
Surveillance data were used to characterize the epidemiology of varicella in Anhui from 2012 to 2021 in terms of population, time, and space. Spatial autocorrelation of varicella was explored using the Moran index (Moran I). The Kulldorff space-time scan statistic was used to analyze the spatiotemporal aggregation of varicella.

Results
A total of 276,115 cases of varicella were reported from 2012 to 2021 in Anhui, with an average annual incidence of 44.8 per 100,000, and the highest incidence was 81.2 per 100,000 in 2019. The male-to-female ratio of cases was approximately 1.26, which has been gradually decreasing in recent years. The population aged 5-14 years comprised the high-incidence group, although the incidence in the population 30 years and older has gradually increased. Students accounted for the majority of cases, and the proportion of cases in both home-reared children (aged 0-7 years who are not sent to nurseries, daycare centers, or school) and kindergarten children (aged 3-6 years) has changed slightly in recent years. There were two peaks of varicella incidence annually, except for 2020, and the incidence was typically higher in the winter peak than in summer. The incidence of varicella in southern Anhui was higher than that in northern Anhui. The average annual incidence at the county level ranged from 6.61 to 152.14 per 100,000, and the varicella epidemics in 2018-2021 were relatively severe. The spatial and temporal distribution of varicella in Anhui was not random, with a positive spatial autocorrelation found at the county level (Moran I=0.412). There were 11 districts or counties with high-high clusters, mainly distributed in the south of Anhui, and 3 districts or counties with high-low or low-high clusters. Space-time scan analysis identified five possible clusters of areas, and the most likely cluster was distributed in the southeastern region of Anhui.

Conclusions
This study comprehensively describes the epidemiology and changing trend of varicella in Anhui from 2012 to 2021. In the future, preventive and control measures should be strengthened for the key populations and regions of varicella.
Effects of a Serious Smartphone Game on Nursing Students' Theoretical Knowledge and Practical Skills in Adult Basic Life Support: Randomized Wait List–Controlled Trial
Authors: Fijačko Nino , Masterson Creber Ruth , Metličar Špela , Strnad Matej , Greif Robert , Štiglic Gregor , Skok Pavel 
Published: April 2024

Background
Retention of adult basic life support (BLS) knowledge and skills after professional training declines over time. To combat this, the European Resuscitation Council and the American Heart Association recommend shorter, more frequent BLS sessions. Emphasizing technology-enhanced learning, such as mobile learning, aims to increase out-of-hospital cardiac arrest (OHCA) survival and is becoming more integral in nursing education.

Objective
The aim of this study was to investigate whether playing a serious smartphone game called MOBICPR at home can improve and retain nursing students’ theoretical knowledge of and practical skills in adult BLS.

Methods
This study used a randomized wait list–controlled design. Nursing students were randomly assigned in a 1:1 ratio to either a MOBICPR intervention group (MOBICPR-IG) or a wait-list control group (WL-CG), where the latter received the MOBICPR game 2 weeks after the MOBICPR-IG. The aim of the MOBICPR game is to engage participants in using smartphone gestures (eg, tapping) and actions (eg, talking) to perform evidence-based adult BLS on a virtual patient with OHCA. The participants’ theoretical knowledge of adult BLS was assessed using a questionnaire, while their practical skills were evaluated on cardiopulmonary resuscitation quality parameters using a manikin and a checklist.

Results
In total, 43 nursing students participated in the study, 22 (51%) in MOBICPR-IG and 21 (49%) in WL-CG. There were differences between the MOBICPR-IG and the WL-CG in theoretical knowledge (P=.04) but not in practical skills (P=.45) after MOBICPR game playing at home. No difference was noted in the retention of participants’ theoretical knowledge and practical skills of adult BLS after a 2-week break from playing the MOBICPR game (P=.13). Key observations included challenges in response checks with a face-down manikin and a general neglect of safety protocols when using an automated external defibrillator.

Conclusions
Playing the MOBICPR game at home has the greatest impact on improving the theoretical knowledge of adult BLS in nursing students but not their practical skills. Our findings underscore the importance of integrating diverse scenarios into adult BLS training.

Trial Registration
ClinicalTrials.gov (NCT05784675); https://clinicaltrials.gov/study/NCT05784675
Pemanfaatan Chromebook dengan Model Project Based Learning Terintegrasi Tri-N Pada Pendidikan Pancasila Sekolah Dasar
Authors: Rahmawati Arini , Wibawa Sutrisna 
Published: April 2024

AbstractEducation is an effort to foster and develop human personality spiritually and physically. This study aims to assess the efficiency of employing Chromebooks with the Project-Based Learning model integrated with Tri N Teachings while examining the challenges faced and initiatives taken in Civic Education for fourth-grade elementary school students. This research adopts a descriptive qualitative approach and involves teachers and students from Class IV at Pakem Kalasan State Elementary School in Sleman Regency. Data collection encompasses interviews, observations, and documentation. Based on the research results, it can be seen that 1) learning activities that utilize Chromebooks in integrated PjBL model Pendidikan Pancasila Learning with Tri N Teachings in Class IV of Pakem Kalasan Elementary School, Sleman Regency provide deeper understanding and experience and foster creativity in students, 2) obstacles in carrying out activities learning that utilizes Chromebooks in integrated PjBL model PKN Learning Tri N Teachings, namely the lack of teacher knowledge in utilizing Chromebooks that are available in educational units as well as the lack of teachers in implementing innovative learning models in the classroom, and 3) Efforts have been undertaken through the organization of In-House Training (IHT) sessions for teachers with the aim of enhancing their competence in effectively utilizing and implementing diverse and innovative teaching methods within the classroom.-------------Abstrak Pendidikan adalah usaha membina dan mengembangkan kepribadian manusia baik dibagian rohani atau dibagian jasmani. Tujuan penelitian ini adalah untuk mengetahui efektivitas pemanfaatan chromebook dengan model Project Based Learning terintegrasi Ajaran Tri N, hambatan dan usaha yang dilakukan pada mata pelajaran Pendidikan Pancasila di Kelas IV siswa Sekolah Dasar. Penelitian ini merupakan penelitian kualitatif deskriptif. Subjek penelitian adalah guru dan siswa kelas IV Sekolah Dasar Negeri Pakem Kalasan Kabupaten Sleman. Teknik pengumpulan data melalui wawancara, observasi dan dokumentasi. Berdasarkan hasil penelitian dapat dilihat bahwa 1) aktivitas pembelajaran yang memanfaatkan Chromebook pada Pembelajaran Pancasila model PjBL terintegrasi Ajaran Tri N di Kelas IV SD Negeri Pakem Kalasan Kabupaten Sleman memberikan pemahaman dan pengalaman yang lebih mendalam serta menumbuhkan kreativitas pada siswa, 2) hambatan dalam melaksanakan kegiatan pembelajaran yang memanfaatkan Chromebook pada Pembelajaran Pendidikan Pancasila model PjBL terintegrasi Ajaran Tri N yaitu kurangnya pengetahuan guru dalam memanfaatkan chromebook yang telah tersedia di satuan pendidikan serta kurangnya guru dalam menerapkan model pembelajaran inovatif di dalam kelas, dan 3) usaha yang dilakukan adalah dengan mengadakan IHT (In House Training) kepada guru guna meningkatkan kompetensi dalam memanfaatkan dan menerapkan pembelajaran inovatif dan bervariatif di dalam kelas.
LEXIQUES ET CORPUS AU SERVICE DE LA LITTÉRATIE OCÉANIQUE : PROPRIÉTÉS ET RELATIONS LEXICALES DANS LE DOMAINE DE LA FAUNE MARINE
Authors: ZOLLO Silvia Domenica 
Published: April 2024

Lexicons and Corpora Serving Ocean Literacy: Properties and Lexical Relations in the Field of Marine Fauna. In this article, we present the first steps of the Ocean Literacy project, which aims to promote the creation and processing of a comparable medium-sized specialised corpus (French-Italian) in the field of marine fauna as well as the creation of a lexicographic resource to describe the lexical relations between the terminological units (TUs) of the field in question, using the theoretical framework of Explanatory and Combinatorial Lexicology. After describing the methodological and theoretical choices made when compiling and processing the ZooCor (fr-it) corpus, we will proceed to the analysis of the French term candidates resulting from semi-automatic extraction using TermoStat software. We will then describe the general architecture of the lexicographic resource ZooTerm which is currently under development, and explain, with the help of a terminographical data model and concrete examples, why we chose to use lexical functions to systematically encode the relations between terms associated with the marine fauna domain. Finally, we will discuss the results and the main theoretical issues raised from this exploratory work.
Lexicoane și corpusuri în slujba alfabetizării oceanice: proprietăți și relații lexicale în domeniul faunei marine. În acest articol, prezentăm primele etape ale proiectului Ocean Literacy, care are ca scop promovarea creării și prelucrării unui corpus specializat comparabil de dimensiuni medii (franceză-italiană) în domeniul faunei marine și crearea unei resurse lexicografice pentru a descrie relațiile lexicale dintre unitățile terminologice (UT) din domeniul în cauză, utilizând cadrul teoretic al lexicologiei explicative și combinatorii. După ce vom descrie alegerile metodologice și teoretice făcute la compilarea și prelucrarea corpusului ZooCor (fr-it), vom trece la analiza termenilor francezi candidați rezultați în urma extragerii semiautomate cu ajutorul programului TermoStat. Vom detalia apoi arhitectura generală a resursei lexicografice ZooTerm în curs de dezvoltare și vom explica, cu ajutorul unui model de fișă terminografică și a unor exemple concrete, motivele care ne-au determinat să folosim funcțiile lexicale pentru a codifica în mod sistematic relațiile dintre termenii asociați cu domeniul faunei marine. În cele din urmă, vom discuta rezultatele și principalele probleme teoretice care decurg din această activitate exploratorie.
Cuvinte-cheie: lexicon, corpus, alfabetizare oceanică, faună marină, relații lexicale
Article history: Received 06 October 2023; Revised 15 December 2023; Accepted 31 January 2024; Available online 27 March 2024; Available print 27 March 2024.
Leash-related injuries associated with dog walking: an understudied risk for dog owners?
Authors: Rosa Rodrigo , Buckley Richard E. 
Published: April 2024

Abstract
The topic of dog-walking injuries has recently gained notoriety through major media outlets in North America, including the Washington Post, NPR, and US News and World Report. In this review, we have compiled data from the main studies published in the past 2 decades that assess the incidence, demographics, and injury patterns related to dog leash walking. The available papers indicate that dog leash–related injuries have increased, particularly among women over 65. The most common causes of injury are dog-pulling behavior, which can result in tripping or tangling, with or without a fall, as well as upper extremity injuries. However, there is a lack of information regarding dog size, breed, training status, the type of leash used at the time of injury, and the role each factor may have in the incidence of injuries. The available data did not allow for evaluation of the impact of weather conditions on injury incidence. Information about the involved dogs, type of lead device, and weather conditions could be useful in identifying risk factors associated with dog ownership and guide prospective pet owners and their families to mitigate the risk of injuries.
Influences of Environment Context and E-Business Adoption on Business Performance of The Retail Ready-Made Garment Business
Authors: Siriwatpatara Rapeepun , Rojniruttikul Nuttawut 
Published: April 2024

Purpose: The objective of this research was to study the influences that affect the business performance of the retail ready-made garment businesses.

Method: The study focused on the use of a quantitative method with a questionnaire as the tool for data collection from a sample of 240 retail ready-made garment businesses. Data analyses included descriptive statistics and the Structural Equation Model (SEM).

Results and Discussions: The findings revealed that the Chi-square = 60.175, df = 44, CMIN/DF = 1.770, GFI=.963, CFI=.992, AGFI=.914, and RMSEA= .055 The structural equation model demonstrated that the environment context and e-business adoption influence the business performance of retail ready-made garment businesses with statistical significance. The variance of the business performance to use was affected by all two factors 74% (R2 = .74) while the remainder was affected by other factors. Nevertheless, it was also revealed that, in the operation of retail ready-made garment businesses, the value chain for e-businesses includes business performance, production, logistics, the infrastructure of human resources, and finance. E-business adoption influences business performance by beneficially leading to efficient operations and the sustainable growth of organizations.

Research Implications: Nowadays, the direction of the market and consumers' behavior changes continuously. Naturally, fashion products run in competition with customer demand. At the same time, the duration of sales is starting to shorten due to the faster changing social conditions than in the past. Moreover, the purchasing tendency of customers changes and the product price starts to be lower. However, they focus on buying mix and match garments according to the fashion trend and at a friendly price. Furthermore, the lifestyle of a customer in the new age builds a bond with technology access, such as internet access/ online social via communication devices. These devices are elevated to major roles in modern lifestyles, such as smartphones. It affects alertness in online shopping and greatly influences daily shopping. Entrepreneurs must adjust strategies and business management to be more efficient and effective.

Originality/Value: Therefore, the retail ready-made garment business has changed from the past in a high number, in terms of consumption behaviors of target customers, patterns of business administration, and marketing strategy.
Factors Influencing Behavioral Intention to Use Intelligent Maintenance Systems: A Study of a Petrochemical Company in Map Ta Phut Industrial Estate
Authors: Chantraporn Puck , Thaweepaiboonwong Jutamard 
Published: April 2024

Purpose: This study aimed to explore the factors influencing the intention to use an intelligent maintenance system by employees who work at the maintenance function in a petrochemical company located in Map Ta Put Industrial Estate, Thailand.

Method: This study is survey research collecting data by a questionnaire from 205 employees selected by simple random method. Data was analyzed by descriptive and inferential statistics. Hypotheses were tested by confirmatory factor analysis (CFA) and structural equation modeling (SEM). In order to determine the factors that affected employees' intentions to use the intelligent maintenance system, Davis's Technology Acceptance Model (TAM) was implemented.

Result and Discussion: The result showed Technology Self-efficacy, Perceived Ease of Use, and Attitude toward Use have direct and indirect influences on employees’ intentions to use an intelligent maintenance system. The model explained 73.5% of the variation in employees’ intentions to use an intelligent maintenance system.

Research Implications: The result explains useful implications for management who relate to the use of intelligent maintenance systems in petrochemical companies.

Originality/Value: The findings are beneficial to the petrochemical company in making an intention to use an intelligent maintenance system by employees who work at the maintenance function in located in Map Ta Put Industrial Estate, Thailand.
Methodology for Assessing Retrofitted Hydrogen Combustion and Fuel Cell Aircraft Environmental Impacts
Authors: Alsamri Khaled , De la Cruz Jessica , Emmanouilidi Melody , Huynh Jacqueline , Brouwer Jack 
Published: April 2024

Hydrogen ([Formula: see text]) combustion and solid oxide fuel cells (SOFCs) can potentially reduce aviation-produced greenhouse gas emissions compared to kerosene propulsion. This paper outlines a methodology for evaluating performance and emission tradeoffs when retrofitting conventional kerosene-powered aircraft with lower-emission [Formula: see text] combustion and SOFC hybrid alternatives. The proposed framework presents a constant-range approach for designing liquid hydrogen fuel tanks, considering insulation, sizing, center of gravity, and power constraints. A lifecycle assessment evaluates greenhouse gas emissions and contrail formation effects for carbon footprint mitigation, while a cost analysis examines retrofit implementation consequences. A Cessna Citation 560XLS+ case study shows a 5% mass decrease for [Formula: see text] combustion and a 0.4% mass decrease for the SOFC hybrid, at the tradeoff of removing three passengers. The lifecycle analysis of green hydrogen in aviation reveals a significant reduction in [Formula: see text] emissions for [Formula: see text] combustion and SOFC systems, except for natural-gas-produced [Formula: see text] combustion, when compared to Jet-A fuel. However, this environmental benefit is contrasted by an increase in fuel cost per passenger-km for green [Formula: see text] combustion and a rise for natural-gas-produced [Formula: see text] SOFC compared to kerosene. The results suggest that retrofitting aircraft with alternative fuels could lower carbon emissions, noting the economic and passenger capacity tradeoffs.