bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fluoreszenzbasierte Konfokalmikroskopie – vollständige Digitalisierung der Pathologie
Authors: Loth Andreas G. , Fassl Anne , Chun Felix K. H. , Köllermann Jens , Hartmann Sylvia , Gretser Steffen , Ziegler Paul K. , Flinner Nadine , Schulze Falko , Wild Peter J. , Kinzler Maximilian N. 
Published: March 2024

Zusammenfassung
Hintergrund
Mit Hilfe der fluoreszenzbasierten Konfokalmikroskopie (FCM) lassen sich virtuelle HE-Schnitte in Echtzeit erstellen. Bislang findet die FCM Anwendung in der Derma‑/Uro- und Gynäkopathologie. Die FCM eröffnet die Perspektive eines digitalen Gefrierschnitts, der den herkömmlichen Gefrierschnitt in Zukunft ersetzen könnte.

Ziel der Arbeit (Fragestellung)
Ziel unserer aktuellen Arbeit ist die Implementierung der FCM als Bestandteil vollständig digitalisierter Abläufe im pathologischen Workflow. Hierfür wird der aktuelle Einsatz der FCM in der Transplantationspathologie auf weitere Fachdisziplinen wie Urologie und HNO ausgeweitet.

Material und Methoden
Der Einsatz der FCM-Technik erfolgt aktuell weiterhin prospektiv bei nativen Gewebeproben potenzieller Spenderlebern. Die herkömmliche Schnellschnittdiagnostik in Gefriertechnik wird vergleichend zu virtuellen FCM-Scans angewandt.

Ergebnisse
Die Daten zeigen eine nahezu perfekte Übereinstimmung für den Nachweis von Cholangitis, Fibrose und Malignität sowie ein hohes Maß an Übereinstimmung für z. B. makrovesikuläre Steatose, Entzündung, Steatohepatitis und Nekrose zwischen virtuellem FCM-Scan und herkömmlichen Schnellschnitt.

Schlussfolgerung
Da die Verfügbarkeit der zeit-, und kostenintensiven Schnellschnittdiagnostik im Rahmen der Transplantationspathologie im Dauerbetrieb (24/7) aufgrund eines zunehmenden Fachkräftemangels mittlerweile nur noch an sehr wenigen universitären Zentren in Deutschland etabliert ist, könnte der Einsatz der FCM-Technik ein wichtiger Baustein im aktuellen Prozess hin zu einer vollständig digitalisierten Pathologie sein und sollte somit auf verschiedene Fachdisziplinen ausgeweitet werden.
Die ärztliche Berufsausübungsgemeinschaft nach dem MoPeG
Authors: Schäfer Carsten , Harf Alexandra 
Published: March 2024

ZusammenfassungDas MoPeG verändert das Recht der Personengesellschaften grundlegend. Soweit die ärztliche
Zusammenarbeit in Form einer GbR mit einem auf die speziellen Bedürfnisse zugeschnittenen Gesellschaftsvertrag
erfolgt, hat die Reform gleichwohl kaum Auswirkungen auf den Praxisalltag. Im Detail kann aber Handlungsbedarf
bestehen, insbesondere mit Blick auf das neue Gesellschaftsregister, auf die geänderten Rechtsfolgen
von Kündigung, Tod oder Gesellschafterinsolvenz und das neue Beschlussmängelrecht. Der Beitrag
nimmt daher die neuen Regeln in den Blick und spricht Handlungsempfehlungen aus. Zudem hat §107 Abs.
1 S. 2 HGB die Personenhandelsgesellschaften für Freiberufler geöffnet. Daher fragt der Beitrag
auch, ob eine Ärzte-OHG/KG eine sinnvolle Rechtsformalternative bildet. Nur ein kurzer Blick wird
auf die Partnerschaftsgesellschaft geworden; hier sind kaum Änderungen zu verzeichnen.
Wie viel „BIO“ braucht die Ökohydraulik? – Neue Ansätze und Modellentwicklungen für die integrative Wasserwirtschaft
Authors: Hauer Christoph , Tritthart Michael , Flödl Peter , Holzapfel Patrick , Unfer Günther , Graf Wolfram , Leitner Patrick , Habersack Helmut 
Published: March 2024

ZusammenfassungDie Modellierung von aquatischen Lebensräumen gewinnt durch die verschiedenen Zielvorgaben auf europäischer und somit auch nationaler Ebene immer mehr an Bedeutung. Neben den Vorgaben der Wasserrahmenrichtlinie und den Zielen zum Ausbau der erneuerbaren Energieträger, inkl. Wasserkraft, sind es auch die neuen Strategien zur Biodiversität und die RED III-Verordnung, die eine integrative Betrachtung der Nutzung aber auch der Sanierung von Fließgewässern zwingend erforderlich machen. Ziel der vorliegenden Arbeit ist es, neue Ansätze der integrativen Modellierung von Lebensräumen in Bezug auf den Einfluss unterschiedlicher Aspekte der Wasserkraftnutzung zu präsentieren. Die Ergebnisse der numerischen Modelle zeigen, dass hier sowohl für Fragen des Sedimentmanagements bei Stauhaltungen von Kleinwasserkraftanlagen als auch bei Spülungen von Feinsedimenten generell ökologische Optimierungen bzw. Abschätzungen der ökologischen Folgen möglich sind. Weiters liefern neue Habitatbewertungsmethoden die Möglichkeit, die Auswirkungen flussbaulicher Maßnahmen oder morphologischer Eigenschaften quantitativ in Bezug auf Schwall-Sunk-Einflüsse zu bewerten. Obwohl diese Prognosemodelle immer ausgereifter sind und immer mehr Prozesse abbilden können, zeigt die Gesamtdiskussion, dass es vor allem weiterhin Grundlagenforschung im Feld, als auch im Experiment braucht, um die integrative Modellierung mit den maßgeblichen biologischen Informationen auszustatten.
Effects of Intravenous Infusion of Iodine Contrast Media on the Tracheal Diameter and Lung Volume Measured with Deep Learning-Based Algorithm
Authors: Yasaka Koichiro , Saigusa Hiroyuki , Abe Osamu 
Published: March 2024

AbstractThis study aimed to investigate the effects of intravenous injection of iodine contrast agent on the tracheal diameter and lung volume. In this retrospective study, a total of 221 patients (71.1 ± 12.4 years, 174 males) who underwent vascular dynamic CT examination including chest were included. Unenhanced, arterial phase, and delayed-phase images were scanned. The tracheal luminal diameters at the level of the thoracic inlet and both lung volumes were evaluated by a radiologist using a commercial software, which allows automatic airway and lung segmentation. The tracheal diameter and both lung volumes were compared between the unenhanced vs. arterial and delayed phase using a paired t-test. The Bonferroni correction was performed for multiple group comparisons. The tracheal diameter in the arterial phase (18.6 ± 2.4 mm) was statistically significantly smaller than those in the unenhanced CT (19.1 ± 2.5 mm) (p < 0.001). No statistically significant difference was found in the tracheal diameter between the delayed phase (19.0 ± 2.4 mm) and unenhanced CT (p = 0.077). Both lung volumes in the arterial phase were 4131 ± 1051 mL which was significantly smaller than those in the unenhanced CT (4332 ± 1076 mL) (p < 0.001). No statistically significant difference was found in both lung volumes between the delayed phase (4284 ± 1054 mL) and unenhanced CT (p = 0.068). In conclusion, intravenous infusion of iodine contrast agent transiently decreased the tracheal diameter and both lung volumes.
Manufacturer’s optimal distribution strategy in the platform supply chain: Bundling or add-on?
Authors: Wang Junbin , Wang Shanshan , Shi Yangyan , Venkatesh V. G. , Paul Sanjoy Kumar 
Published: March 2024

AbstractThis study delves into the realm of distribution strategies employed in retail markets, particularly focusing on the widely utilized bundle-and-add-on strategy. Three distinct distribution strategies are examined: bundled-by-the-base-manufacturer (BBBM), bundled-by-the-platform, and the add-on approach within a platform supply chain context. Through comprehensive analysis, this paper investigates the optimal distribution strategy for manufacturers. Significantly, our research reveals that in cases where only bundling is feasible, base manufacturers can reap benefits from a self-bundling strategy when both the platform’s commission rate and the marginal cost of the bundled product are low. Additionally, the platform stands to gain from this approach when the commission rate is low, and the marginal cost of the bundled product is either moderate or very high. Notably, win–win scenarios can emerge for both manufacturers and platforms through specific bundling or platform bundling strategies under specific conditions. Furthermore, the study demonstrates that the price of bundles under the add-on strategy will be lower, attracting more consumers, especially when the commission rate is low. Intriguingly, when the marginal cost of the base product is low, the add-on strategy consistently emerges as the optimal choice; as costs escalate, BBBM might be optimal, especially when the commission rate is low, showcasing a nuanced understanding of the interplay between costs and strategic choices in distribution. The major contribution of this paper lies in its nuanced analysis of these strategies and their implications for both manufacturers and platforms in the retail landscape.
The Role of MicroRNA-206 in the Regulation of Diabetic Wound Healing via Hypoxia-Inducible Factor 1-Alpha
Authors: Bai Zeming , Zhou Dapeng , Tao Kai , Lin Feng , Wang Hongyi , Sun Haiwei , Liu Ruidi , Li Zhe 
Published: March 2024

Abstract
Successful wound healing in diabetic patients is hindered by dysregulated miRNA expression. This study aimed to investigate the abnormal expression of miRNAs in diabetic wound healing and the potential therapeutic role of modulating the miR-206/HIF-1α pathway. MicroRNA assays were used to identify differentially expressed miRNAs in diabetic wound sites and adjacent areas. In vitro models and a rat diabetic model were established to evaluate the effects of miR-206 on HIF-1α regulation and wound healing. The study revealed differential expression of miR-206 in diabetic wound tissues, its interaction with HIF-1α, and the inhibitory effect of miR-206 on cell growth under high glucose conditions. Modulating the miR-206/HIF-1α pathway using miR-206 antagomir promoted HIF-1α, CD34, and VEGF expression, ultimately enhancing diabetic wound healing.
Cognitive Reappraisal Moderates the Longitudinal Relationship between Adolescents’ Peer Victimization and Self-Esteem. A Latent Interaction Model
Authors: Spyropoulou Elli , Giovazolias Theodoros 
Published: March 2024

AbstractPoor self-esteem relates closely to youth maladjustment and appears to be predicted by peer victimization experiences. However, not all peer victimized adolescents face the same risk for self-esteem erosion over time. Drawing upon the Bi-Dimensional Framework for resilience and extant research, the present study examined the potential moderating role of cognitive reappraisal in the prospective relationship from peer victimization to self-esteem. To increase precision of findings the long-term impact of self-esteem on peer victimization was also tested. Self-reported data were collected from 285 early adolescents (Mage = 10.53 years, SD = 0.16; 54.0% girls) at two waves, spaced 1-year. Latent moderated structural equation analysis showed that peer victimization was negatively related to later self-esteem, but only for youth displaying low levels of cognitive reappraisal. For adolescents with high levels of cognitive reappraising, peer victimization was not found to predict any changes in self-esteem over time. The long-term impact of self-esteem on peer victimization was not supported. Overall the present study suggests that enhancing cognitive reappraisal could be a promising avenue for lowering risk for poor self-esteem in young individuals experiencing peer victimization.
Intentional astrobiological signaling and questions of causal impotence
Authors: Haramia Chelsea 
Published: March 2024

AbstractMy focus is on the contemporary astrobiological activity of Messaging ExtraTerrestrial Intelligence (METI). This intentional astrobiological signaling typically involves embedding digital communications in powerful radio signals and transmitting those signals out into the cosmos in an explicit effort to make contact with extraterrestrial others. Some who criticize METI express concern that contact with technologically advanced extraterrestrial life could be seriously harmful to Earth or humanity. One popular response to this critique of messaging is an appeal to causal impotence sometimes referred to as the ‘Barn Door’ Argument—we are already engaged in many other detectable activities not intended for cosmic communication. If the Barn Door Argument is correct, then those who engage in messaging arguably have a moral excuse. They are permitted to continue messaging because there is no point in abstaining. I develop three ways in which the claim of causal impotence in the Barn Door Argument could be understood. I evaluate each of these in turn and demonstrate that only one is appropriate to contemporary messaging. However, this interpretation does not generate the moral excuse on which the proponents of the Barn Door Argument rely; thus, the argument fails. Finally, I entertain and respond to candidate objections.
The 2022 Goesan earthquake of the moment magnitude 3.8 along the buried fault in the central Korean Peninsula
Authors: Lim Hobin , Cho Chang Soo , Son Minkyung 
Published: March 2024

AbstractOn October 28, 2022, a moment magnitude (Mw) 3.8 earthquake occurred in Goesan, South Korea, typically characterized as a stable continental region. Herein, we analyze 42 earthquakes, including the Mw 3.8 earthquake, the largest foreshock (Mw 3.3), which preceded the mainshock by 17 s, and the largest aftershock (Mw 2.9). The primary aim of this study is to identify interactions among the seismic events. To this end, we utilized the permanent seismic networks with the closest station at 8.3 km from the epicenter, and the temporary network deployed eight hours after the mainshock’s occurrence. Relocation results delineate that the mainshock occurred at the southeastern tip of the hypocenter distribution of three foreshocks, trending west-northwest–east-southeast. The aftershocks form an overall spatially diffused seismic pattern that propagates toward both ends of the inferred lineament in the downdip direction. The rupture directivity of the mainshock, along with waveform similarity across the mainshock and foreshocks, confirms the inferred geometry, corresponding well with the focal mechanisms of the mainshock and the largest foreshock. We demonstrate that the change in Coulomb failure stress (ΔCFS) by the largest foreshock was positive where the mainshock occurred and that the mainshock generated ΔCFS capable of triggering the propagation of the aftershocks.
Adventure and contingency in literary theory
Authors: Stockhammer Robert 
Published: March 2024

AbstractThe relation between adventure and contingency is an ambivalent one. This ambivalence can be described by using a distinction of two aspects already tied together in âventiure (as a French foreign word in German), distinguished by Jacob Grimm as “begebenheit” versus “erzählte geschichte selbst,” rendered as ‘type of event’ versus ‘narrative pattern’ in the terminology of the Munich research group Philology of Adventure. On the one hand, it seems obvious that for an adventure, as a type of event, a contingent element is a crucial precondition. An adventurous agent must willingly expose himself to this contingent event and interpret it as a ‘Chance’ (using a French foreign word in German, again), i.e. as opportunity to gain by risking, be it simply capital—as in the economic usage of the word, from English ‘Merchant Adventurers’ to contemporary ‘Venture Capital’—, or be it fame or prestige—as in Medieval and Early Modern adventure epics and novels. On the other hand, adventure, as a narrative pattern, tends to reduce contingencies in order to ‘make sense’. Even if adventure tales tolerate and actually support episodic structures, these episodes must, after all, be motivated and integrated into a plot. In other words: Writing an adventure story always already implies to tame (or perhaps rather frame) the very contingency it is based on. Adventure stories are therefore typical cases of “eliminat[ing] the contingent part of the literary phenomena it deals with” (Duprat and Jordan, introduction to the present special issue). This tension is, however, rarely acknowledged in the history of literary theory—here taken in the longue durée, starting with Early Modern poetics. The present essay discusses some steps from the history of relevant theories, with a particular emphasis on Giorgio Agamben's recent eulogy of adventure.
Legitimising capital: parent organisations and their resistance to testing in England
Authors: Holloway Jessica , Santori Diego 
Published: March 2024

AbstractThis paper presents findings from a year-long network ethnography into the strategies, networks, and outcomes of More Than a Score (MTAS)—a campaign against standardised testing in UK primary schools. Focusing specifically on the parent-based groups of the organisation, we use theorisations of symbolic capital to challenge traditional understandings of how capital can be leveraged for group advancement. We argue that MTAS frames itself as a grassroots organisation, using this image to promote its agenda amongst possible allies. Parent groups serve a critical role in accentuating the ‘grassroots’ image, as they bring a level of credibility to this claim. At the same time, the individuals who run these groups also bring technical skills, professional experiences, and connections that provide logistical and expert capital to the range of MTAS’s strategies and agendas. In doing so, their political and social capital as ‘parents’ provide a sort of legitimising capital to MTAS.
Domain Generalization with Small Data
Authors: Chen Kecheng , Gal Elena , Yan Hong , Li Haoliang 
Published: March 2024

AbstractIn this work, we propose to tackle the problem of domain generalization in the context of insufficient samples. Instead of extracting latent feature embeddings based on deterministic models, we propose to learn a domain-invariant representation based on the probabilistic framework by mapping each data point into probabilistic embeddings. Specifically, we first extend empirical maximum mean discrepancy (MMD) to a novel probabilistic MMD that can measure the discrepancy between mixture distributions (i.e., source domains) consisting of a series of latent distributions rather than latent points. Moreover, instead of imposing the contrastive semantic alignment (CSA) loss based on pairs of latent points, a novel probabilistic CSA loss encourages positive probabilistic embedding pairs to be closer while pulling other negative ones apart. Benefiting from the learned representation captured by probabilistic models, our proposed method can marriage the measurement on the distribution over distributions (i.e., the global perspective alignment) and the distribution-based contrastive semantic alignment (i.e., the local perspective alignment). Extensive experimental results on three challenging medical datasets show the effectiveness of our proposed method in the context of insufficient data compared with state-of-the-art methods.
Dynamic Effects of a Regulating Valve in the Assessment of Water Leakages in Single Pipelines
Authors: Coronado-Hernández Oscar E. , Pérez-Sánchez Modesto , Arrieta-Pastrana Alfonso , Fuertes-Miquel Vicente S. , Coronado-Hernández Jairo R. , Quiñones-Bolaños Edgar , Ramos Helena M. 
Published: March 2024

AbstractWater losses in water distribution systems are typically analysed using extended period simulations, where its numerical resolution is commonly achieved using the gradient method. These models assume that adjustments to regulating valves occur, either manually or automatically, over an extended period of time, then the system inertia can be neglected. This research introduces the development of a rigid water column model for analysing water leakages in single pipelines, which can be employed to account for regulation valve adjustments in shorter time periods, thereby providing greater accuracy when assessing water losses. The application to a case study is presented to analyse pressure variations and leakage flow patterns over 30, 60, and 180 s. A comparison between the extended period simulation and rigid water column model is presented in order to note the order of magnitude on leakages when the system inertia is not considered. The results confirm that is crucial for water utilities the consideration of inertial system to simulate adequately opening and closure manoeuvres in water distribution systems, since according to the case study the extended period simulation can overestimated or underestimated the total leakage volume in percentages of 37.1 and 55.2 $$\%$$
%
, respectively.
Circulating N-lactoyl-amino acids and N-formyl-methionine reflect mitochondrial dysfunction and predict mortality in septic shock
Authors: Rogers Robert S. , Sharma Rohit , Shah Hardik B. , Skinner Owen S. , Guo Xiaoyan A. , Panda Apekshya , Gupta Rahul , Durham Timothy J. , Shaughnessy Kelsey B. , Mayers Jared R. , Hibbert Kathryn A. , Baron Rebecca M. , Thompson B. Taylor , Mootha Vamsi K. 
Published: March 2024

Abstract
Introduction
Sepsis is a highly morbid condition characterized by multi-organ dysfunction resulting from dysregulated inflammation in response to acute infection. Mitochondrial dysfunction may contribute to sepsis pathogenesis, but quantifying mitochondrial dysfunction remains challenging.

Objective
To assess the extent to which circulating markers of mitochondrial dysfunction are increased in septic shock, and their relationship to severity and mortality.

Methods
We performed both full-scan and targeted (known markers of genetic mitochondrial disease) metabolomics on plasma to determine markers of mitochondrial dysfunction which distinguish subjects with septic shock (n = 42) from cardiogenic shock without infection (n = 19), bacteremia without sepsis (n = 18), and ambulatory controls (n = 19) – the latter three being conditions in which mitochondrial function, proxied by peripheral oxygen consumption, is presumed intact.

Results
Nine metabolites were significantly increased in septic shock compared to all three comparator groups. This list includes N-formyl-l-methionine (f-Met), a marker of dysregulated mitochondrial protein translation, and N-lactoyl-phenylalanine (lac-Phe), representative of the N-lactoyl-amino acids (lac-AAs), which are elevated in plasma of patients with monogenic mitochondrial disease. Compared to lactate, the clinical biomarker used to define septic shock, there was greater separation between survivors and non-survivors of septic shock for both f-Met and the lac-AAs measured within 24 h of ICU admission. Additionally, tryptophan was the one metabolite significantly decreased in septic shock compared to all other groups, while its breakdown product kynurenate was one of the 9 significantly increased.

Conclusion
Future studies which validate the measurement of lac-AAs and f-Met in conjunction with lactate could define a sepsis subtype characterized by mitochondrial dysfunction.
Rassifizierende Humandifferenzierung. Ein Plädoyer für spezifizierende Vergleiche statt ethno–zentrischer Subsumtion
Authors: Hirschauer Stefan , Krings Matthias 
Published: March 2024

ZusammenfassungLoic Wacquant ist zuzustimmen, dass „Rassen“ für die Soziologie nur eine ethnosoziologische Kategorie einer rassifizierenden Praxis sein können und dass international gebräuchliche Begriffe von Race implizit auf einem ethnozentrischen Begriff der US-Gesellschaft beruhen. Dort wird Race freilich auch von den Dominierten substanzialisiert und essenzialisiert. Für den konzeptuellen Rassismus ist eine Reifikationsallianz sozialer Bewegungen und kritischer Soziologie verantwortlich. Eine große Schwäche der Agenda Wacquants liegt darin, dass seine Subsumtion von Race unter einen vagen Begriff von Ethnizität diesen ethno–zentrisch überdehnt. Sie macht es unmöglich zu bestimmen, was allgemein und was spezifisch ist an Race. Stattdessen braucht es spezifizierende Vergleiche von Formen der Humandifferenzierung: Race, Ethnizität, Konfession, Sprache und Staatsbürgerschaft sollten erstens analytisch klar separiert werden, bevor man zweitens darangeht, im Vergleich mit weiteren Unterscheidungen (wie Geschlecht, Klasse, Alter, Disability) ihre Familienähnlichkeiten zu bestimmen, und drittens ihre empirischen Interferenzen mit anderen Unterscheidungen untersucht.