bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of a Two-Step Fuzzy-AHP and TOPSIS Methodology in Urban Access Road Route Selection
Authors: Sulistyorini Rahayu , Yuliyanto Andry , Ekaputra Reza , Setiawan Bima , S Andi 
Published: March 2024

Abstract
Route selection is a critical component in establishing a sustainable infrastructure. The goal of this study is to evaluate and rank alternative access routes based on relevance, and subsequently identify the most efficient route. This process involves an exhaustive literature review and consultations with transportation planning experts to determine the criteria for selection. The Fuzzy Analytic Hierarchy Process (F-AHP) was utilized to determine the weights of these criteria, and the Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS) was implemented in the decision-making process to identify the optimal route. This research focuses on a specific route selection problem between Kunyit Beach and Puri Gading Beach. The findings of the study reveal that area development is the primary criterion for road route selection. The integration of F-AHP and TOPSIS proved to be an effective method for route selection, providing a systematic and quantifiable decision-making tool. These results suggest potential wider applications of the combined F-AHP and TOPSIS methodology in infrastructure planning and sustainable development. Future research should focus on the utilization of this combined method in various contexts and its potential implications in other aspects of transportation engineering. This research contributes to the literature by highlighting the potential benefits of integrating multiple decision-making techniques in route selection, aiming to promote sustainability and efficiency in infrastructure planning.
Glutamine deprivation in glioblastoma stem cells triggers autophagic SIRT3 degradation to epigenetically restrict CD133 expression and stemness
Authors: Xing Zhengcao , Jiang Xianguo , Chen Yalan , Wang Tiange , Li Xiaohe , Wei Xiangyun , Fan Qiuju , Yang Jie , Wu Hongmei , Cheng Jinke , Cai Rong 
Published: March 2024

Abstract

Glioblastoma multiforme (GBM) is a highly malignant brain tumor, and glioblastoma stem cells (GSCs) are the primary cause of GBM heterogeneity, invasiveness, and resistance to therapy. Sirtuin 3 (SIRT3) is mainly localized in the mitochondrial matrix and plays an important role in maintaining GSC stemness through cooperative interaction with the chaperone protein tumor necrosis factor receptor-associated protein 1 (TRAP1) to modulate mitochondrial respiration and oxidative stress. The present study aimed to further elucidate the specific mechanisms by which SIRT3 influences GSC stemness, including whether SIRT3 serves as an autophagy substrate and the mechanism of SIRT3 degradation. We first found that SIRT3 is enriched in CD133+ GSCs. Further experiments revealed that in addition to promoting mitochondrial respiration and reducing oxidative stress, SIRT3 maintains GSC stemness by epigenetically regulating CD133 expression via succinate. More importantly, we found that SIRT3 is degraded through the autophagy–lysosome pathway during GSC differentiation into GBM bulk tumor cells. GSCs are highly dependent on glutamine for survival, and in these cells, we found that glutamine deprivation triggers autophagic SIRT3 degradation to restrict CD133 expression, thereby disrupting the stemness of GSCs. Together our results reveal a novel mechanism by which SIRT3 regulates GSC stemness. We propose that glutamine restriction to trigger autophagic SIRT3 degradation offers a strategy to eliminate GSCs, which combined with other treatment methods may overcome GBM resistance to therapy as well as relapse.
Investigation of serum elements and biochemical variables as a risk factor for female infertility
Authors: Kaur Mandeep , Kaur Rajinder , Kapoor Harmanpreet Singh , Chhabra Kiran , Khetarpal Preeti 
Published: March 2024

Abstract

Essential elements perform variety of cellular functions of the body and are required in trace amounts. However, non-essential elements are harmful even in small quantities. The aim of the present study was to evaluate the serum levels of a) eight essential (Cr, Co, Ni, Fe, Mn, Cu, Zn, Se), and seven non-essential elements (Pb, Cd, As, Ba, Bi, U, V); and b) seven biochemical parameters namely, glucose, cholesterol, triglycerides, high-density lipoprotein (HDL-C), low-density lipoprotein (LDL-C), albumin, total protein. A total of 139 adult women (49 with primary infertility, 32 with secondary infertility, and 58 with healthy pregnancy) were enrolled from the Malwa region of Punjab, India. Serum element levels were evaluated by inductively coupled plasma mass spectrometry and biochemical variables were evaluated by colorimetric methods. Statistical analysis was conducted using software IBM SPSS statistic version 26 (SPSS, Chicago, IL, USA) and R package version 4.1.3. A significant difference was observed for Cr, Co, Ni, Fe, Mn, Zn, Se, U, V, and Bi between the studied groups. Triglyceride and LDL levels are significantly higher among infertile women (p < 0.05). High serum copper levels are associated with elevated triglyceride levels; however, bismuth is negatively correlated with LDL levels. A higher risk of primary and secondary infertility was found with altered Cu, Co, Mn, Zn, Se, U, V, Bi, cholesterol, triglycerides, and LDL levels. Investigation of metals in the patients with infertility may help to understand the pathogenesis of the disease and could also be useful to plan treatment strategies in future.
Effect of Biological shells aggregate on the Mechanical properties and sustainability of concrete
Authors: Wang Xianpeng , LI Fulong , Yu Haoxuan 
Published: March 2024

Abstract

To solve waste bio-shell and put them into recycle, the researchers proposed using waste bio-shells as aggregate matrix for concrete. In order to determine the substitution amount of shells, the researchers used the orthogonal experimental method, and designed shell concrete experiments with gradient substitution rates at 10%, 30% and 50%, with a total of 78 groups of specimens. By analyzing the tensile, bending and frost resistance of these specimens, the experimental data show that adding shells as aggregate at 10%, 30% or 50% can improve the mechanical properties of the concrete, the maximum flexural strength can be increased by 3.96Mpa, the maximum compressive strength can be increased by 2.5Mpa, but with a degradation of frost resistance. With the investigate of economic performance, it was found that the costs of frame-shear structure, frame structure, and tube-in-tube structure were reduced by 10.2%, 10%, and 10.3% respectively. In the carbon environmental assessment, the carbon reduction of a single specimen with 10%, 30%, and 50% shell addition were 0.003, 0.0010, and 0.0015 kg respectively. In summary, compared with ordinary concrete materials, it is very possible to use waste bio-shells as a substitute for aggregates to develop the sustainable recycling development of concrete materials.
Using Multi-Point Activity Surveys for identification of bat commuting routes and selection of candidate urban dark corridor sites
Authors: Hughes Morgan , Brown Scott K , Redfern Tamar , Perry Rebecca , Maddock Simon T , Young Christopher H 
Published: March 2024

Abstract

Context. In the complex balance between the landscapes of energy and fear, urban artefacts impact the routes taken by commuting bats. Little is known about the movements of urban bats, with mitigation efforts seldom being evidence-based. Knowledge of existing bat movements to inform urban sustainability is crucial.
Objectives. We applied the Multi-Point Activity Survey (MultiPAS) method in two case studies to quantify the use of nightly commuting routes used by bats in an urban landscape and to use those data to select candidate dark corridor sites and key points for retention of vegetation at crossing points.
Methods. Two models of MultiPAS were tested on urban canals, comprising one 2.8 km linear site and five canal junctions in the West Midlands, UK.
Results. The linear model identified important bat ingress and egress points, and a key candidate dark corridor site through a residential area. The junction survey model yielded candidate dark corridors at three junctions, and a crossing point for the retention of vegetation. The combined data also identified two major feeding areas for bats.
Conclusions. The knowledge of existing commuting routes and crossing points is invaluable in urban planning for bat conservation. The knowledge gained by using MultiPAS methods would allow local authorities to select appropriate dark corridor sites in effective, evidence-based and landscape-scale conservation efforts.
Exploring Technology Adoption Trends Among Entrepreneurial Start-ups on the Digital Frontier
Authors: Cooper Mason 
Published: March 2024

Abstract
In the dynamic landscape of the digital frontier, entrepreneurial start-ups play a pivotal role in driving innovation and leveraging technology to disrupt industries and create new markets. Understanding the patterns of technology adoption among these ventures is crucial for both academic research and practical implications. This qualitative research delves into the nuanced factors influencing technology adoption decisions among entrepreneurial start-ups, aiming to shed light on the motivations, challenges, and strategies driving digital innovation in the entrepreneurial ecosystem. Through semi-structured interviews and thematic analysis, this study explores the experiences and perspectives of founders, executives, and technology leaders within start-up ventures. The findings reveal several key themes shaping technology adoption patterns. Firstly, the innovation imperative emerges as a primary driver, with start-ups recognizing the strategic importance of embracing digital solutions to maintain competitiveness and drive innovation. Secondly, resource constraints pose significant challenges, with limited financial resources and technical expertise hindering technology adoption efforts, particularly for early-stage ventures. Furthermore, risk perception varies among start-ups, influencing their technology adoption decisions. While some entrepreneurs are willing to embrace disruptive technologies despite uncertainties, others prioritize risk mitigation and opt for more established solutions. Additionally, the broader entrepreneurial ecosystem exerts significant influence on technology adoption patterns, with external pressures and expectations shaping strategic choices. The insights generated from this research contribute to a deeper understanding of the complex dynamics of technology adoption in the entrepreneurial context. By uncovering the motivations, challenges, and strategies driving technology adoption among start-ups, this study offers valuable implications for scholars, policymakers, and practitioners seeking to navigate the digital frontier and foster innovation in the entrepreneurial ecosystem.
Lysine-Cysteine-Serine-Tryptophan Inserted into the DNA-Binding Domain of Human Mineralocorticoid Receptor Increases Transcriptional Activation by Aldosterone
Authors:   Yoshinao Katsu1, Zhang Jiawen , Baker Michael 
Published: March 2024

Abstract

Due to alternative splicing in the DNA-binding domain (DBD) of the mineralocorticoid receptor (MR), humans contain two almost identical MR transcripts with either 984 amino acids (MR-984) or 988 amino acids (MR-988), in which their DBDs differ by only four amino acids, Lys,Cys,Ser,Trp (KCSW). Human MRs also contain mutations at two sites, codons 180 and 241, in the amino terminal domain (NTD). Together, there are five human MR genes in GenBank. Human MR-984, which was cloned in 1987, has been extensively studied. Human MR-988, cloned in 1995, contains KCSW in its DBD. Neither this human MR-988 nor the other human MR-988 genes have been studied for their response to aldosterone and other corticosteroids. Here, we report that transcriptional activation of human MR-988 by aldosterone is increased by about 50% compared to activation of human MR-984 in HEK293 cells transfected with the TAT3 promoter, while the half-maximal response (EC50) is similar for aldosterone activation of MR-984 and MR-988. The physiological responses in humans with MR genes containing KCSW and with differences in the NTD warrant investigation.
NEW MEANING OF I'JÂZ AL-QUR`ÂN IN M. QURAISH SHIHAB'S THINKING
Authors: Musyafa Mochamad Choirul , Abidin Ahmad Zainal 
Published: March 2024

Abstract
The meaning of I’jaz underwent development in the hand of Quran believers. Quraish Shihab, one of Indonesia mufassir said that the Holy Quran and its miracles do not know the limit of time and space. In ‘Ulûm al-Qur`ân, the speciality which is owned by the Holy Quran is its miracle’s aspects. Those aspects include the spects of its literary, law and creed, science and unseen signals. According to Quraish Shihab, the speciality of the Holy Quran is divided into two; miracles and privileges. For him, the miracle’s aspects of the Holy Quran are literary aspects, scientific and unseen signals. While the privilege of the Holy Koran are another things which are not included in the Holy Koran’s miracles. The things under consideration to say about the miracle of the Holy Quran is that the Prophet Muhammad is an ummî, social circumstances of the Arab community when The Holy Koran was revealed and the type of the Holy Quran’s gradual revelation in some years.
Keywords: I’jaz, Miracle, Privilege, Ummi

Abstrak
Makna I'jaz mengalami perkembangan di tangan orang-orang yang mengimani Al-Quran. Quraish Shihab sebagai salah satu mufassir Indonesia mengatakan bahwa Alquran dan mukjizatnya tidak menegenal batas waktu dan ruang. Dalam ‘Ulûm Al-Quran, kekhasan yang dimiliki oleh Al-Quran adalah aspek i’jaz-nya. Aspek itu meliputi sastra, hukum dan kepercayaan, sains dan isyarat gaib. Menurut Quraish Shihab, kekhasan atau spesialisasi Al-Quran dibagi menjadi dua; keajaiban dan hak istimewa. Baginya, aspek mukjizat Al-Quran adalah aspek sastra, ilmiah dan berita gaib. Sementara keistimewaan Alquran adalah aspek lain yang tidak termasuk dalam mukjizat Alquran. Hal-hal yang mesti dipertimbangkan untuk mengatakan tentang realitas mukjizat Al-Quran adalah bahwa Nabi Muhammad SAW tidak bisa baca tulis (ummî), keadaan sosial jahiliyyah masyarakat Arab ketika Al-Quran diturunkan dan pola pewahyuan Al-Quran bertahap dalam beberapa tahun.
Kata kunci: I'jaz, Keajaiban, Keistimewaan, Ummi
JIHAD GLOBAL
Authors: Fata Ahmad Khoirul , Khamdan Muh. 
Published: March 2024

Abstrak: Radikalisme atas nama Islam kembali marak di Dunia Islam kontemporer. Gerakan ini mewujud dalam berbagai aksi kekerasan dan perlawanan terhadap kelompok-kelompok yang dianggap sebagai musuh Islam. Faktor politik, ekonomi, dan ketidakadilan global yang dbungkus dengan sentimen keagamaan menjadi pendorong kebangkitan gerakan ini. Dengan ideologi “jihad”-nya, mereka menyebarkan pahamnya ke berbagai belahan dunia, tak terkecuali Indonesia. Dengan pendekatan sosio-politik, kajian ini hendak mengkaji ideologi gerakan Jihad Global, pengaruh, dan jaringannya di Indonesia. Dari kajian ini terlihat bahwa gerakan Jihad Global memiliki kaitan erat dengan gerakan reformasi Islam yang merupakan respons atas kemunduran Dunia Islam berhadapan dengan Dunia Barat. Pengembangan ide ini oleh Sayyid Quthb membuat gerakan reformasi bukan sekedar sebagai otokritik atas kondisi umat, namun juga mengeras menjadi ideologi perlawanan terhadap sistem yang dianggap menindas. Ideologi perlawanan inilah yang kemudian mengilhami berbagai gerakan ekstrem di Indonesia pasca reformasi.
Abstract: Radicalism in the name of Islam is re-emerging in the contemporary Islamic world. This movement manifested in various acts of violence and resistance against “enemies of Islam”. Political, economic, and global injustice factors wrapped in religious sentiments are the driving forces for the revival of this movement. With ideology of "jihad", they spread their understanding to various parts of the world, including Indonesia. With a socio-political approach, this study aims to examine the ideology of the Global Jihad movement, its influence, and its network in Indonesia. From this study, it can be seen that the Global Jihad movement is closely related to the Islamic reform movement which is a response to the decline of the Islamic world in dealing with the West. The development of this idea by Sayyid Qutb made the reform movement not only as an autocritic of the condition of the ummah, but also hardened into an ideology of resistance to a system that is considered oppressive. This ideology of resistance then inspired various extreme movements in post-reform Indonesia.
THE STORY OF THE PROPHET YUSUF IN THE QUR'AN: JULIA KRISTEVA'S INTERTEXTUAL APPROACH
Authors: Purnama Rizal Faturohman 
Published: March 2024

This article discusses the story of the Prophet Joseph in the Qur'an. As the story of the Qur'an and the Bible, the story of the Prophet Joseph is very important to find out the difference between the two. Therefore, the approach used is intertextual initiated by Julia Kristeva who seeks to compare the two. By using this approach. There are a lot of differences. In terms of the structure of the Qur'an many simplifications, so the principle of haplology becomes dominant in every fragment. The most fundamental difference between the two is in terms of the theme to be raised, the story of the Prophet Joseph in the Qur'an is themed around the teachings of tawhid, while in the Bible themed power.
Keywords: Prophet Joseph, al-Qur'an, Intertextual

Abstrak
Artikel ini membahas tentang kisah Nabi Yusuf dalam al-Qur’an. Sebagai kisah yang termuat dalam al-Qur’an dan Alkitab, kisah Nabi Yusuf sangat penting untuk ditemukan letak perbedaan antara keduanya. Oleh karena itu, pendekatan yang digunakan adalah intertekstual yang digagas oleh Julia Kristeva yang berusaha untuk membandingkan keduanya. Dengan menggunakan pendekatan ini. Ditemukan banyak perbedaan. Dari segi struktur al-Qur’an banyak melakukan penyederhanaan, sehingga prinsip haplology menjadi dominan dalam setiap fragmen. Perbedaan yang paling mendasar antara keduanya adalah dari segi tema yang hendak dimunculkan, kisah Nabi Yusuf dalam al-Qur’an bertemakan ajaran tauhid, sedangkan dalam Alkitab bertema kekuasaan.
Kata Kunci: Nabi Yusuf, al-Qur’an, Intertekstual
THE MEANING OF THE BODY IN OF DEATH TERROR
Authors: Hudda Safaat Ariful , Najib Abdul 
Published: March 2024

death. Its highly contagious nature makes this disease difficult to treat. This condition forces everyone to rely on their own body’s immune system to survive. However, the negative perspective on the body, that is as an object, often makes people fall into panic, so that it can be fatal. Thus, this article was written in context to give a reflective meaning to the body with the philosophical investigation. The body itself is a facticity for "being" together with the soul (mind) and spirit. By understanding the body as the subject’s mode of existence, that is as being-in-the-world, humans can prepare themselves for any eventuality that may occur, including death.
Keywords: Covid-19, Body, Death
Abstrak
Pandemi Covid-19 saat ini menghadirkan teror kepada manusia berupa kematian massal. Sifatnya yang sangat menular membuat penyakit ini sulit diobati. Kondisi ini memaksa setiap orang untuk mengandalkan sistem kekebalan tubuhnya sendiri untuk bertahan hidup. Namun, cara pandang negatif terhadap tubuh, yaitu sebagai objek, seringkali membuat orang menjadi panik, sehingga bisa berakibat fatal. Dalam konteks inilah artikel ini ditulis yaitu untuk memberi makna reflektif terhadap tubuh menggunakan perspektif filosofis. Tubuh sendiri merupakan sebuah faktisitas bagi “ada” bersama dengan jiwa (akal budi) dan ruh. Dengan memahami tubuh sebagai cara keberadaan subjek, yaitu sebagai eksistensi di dunia (being in the world), manusia dapat mempersiapkan diri untuk segala kemungkinan yang mungkin terjadi, termasuk kematian.
Kata Kunci: Covid-19, Tubuh, Kematian
Patriotic education as a necessary factor for Russian statehood
Authors: Aksenov A. A. , Fofanova A. Yu 
Published: March 2024

The article examines the term “patriotism” and the significance of its meaning, drawing attention to the changes taking place in society and patriotic activities being conducted in Voronezh and Murmansk Regions in order to promote patriotism among young people.The presented material proves the need for constant work on promoting patriotism in society as a factor in the development of civic engagement among the citizens of the country, readiness to selflessly serve their country, and respect for law and order, which is a mobilizing resource for the development of modern Russian society.
Deformable Vesicles with Edge Activators for the Transdermal Delivery of
Non-Psychoactive Cannabinoids
Authors: Vettorato Elisa , Fiordelisi Marisa , Ferro Silvia , Zanin Desirè , Franceschinis Erica , Marzaro Giovanni , Realdon Nicola 
Published: March 2024

Background:
Transdermal delivery of highly lipophilic molecules is challenging due to the strong
barrier function of the skin. Vesicles with penetration enhancers are safe and efficient systems that could improve
the transdermal delivery of non-psychoactive cannabinoids such as cannabidiol and desoxy-cannabidiol.
In the last decades, research interest in desoxy-cannabidiol as a potent drug with anti-nociceptive properties
has risen. Still, its scarce market availability poses a limit for both research and clinical applications. Therefore,
it is necessary to improve the synthesis to produce sufficient amounts of desoxy-cannabidiol. Moreover,
also the formulation aspects for this drug are challenging and require to be addressed to meet an efficient delivery
to the patients.

Objective:
This work aimed to develop innovative phospholipid-based vesicles with propylene glycol (PG),
oleic acid (OA), or limonene as edge activators, for the transdermal delivery of highly lipophilic drugs such as
non-psychoactive cannabinoids. In particular, desoxy-cannabidiol was selected thanks to its anti-nociceptive
activity, and its synthesis was improved enhancing the stereoselectivity of its synthon's production.

Methods:
Desoxy-cannabidiol was synthesized by Lewis acid-mediated condensation of p-mentha-2,8-dien-
1-ol and m-pentylphenol, improving the stereoselectivity of the first synthon's production. Transethosomes
containing 20-50% w/w PG, 0.4-0.8% w/w OA, or 0.1-1% w/w limonene were optimized and loaded with
cannabidiol or desoxy-cannabidiol (0.07-0.8% w/w, 0.6-7.0 mg/mL). Ex-vivo studies were performed to assess
both the skin permeation and accumulation of the cannabinoids, as well as the penetration depth of fluorescein-
loaded systems used as models.

Results:
An enantioselective bromination was added to the pathway, thus raising the production yield of pmentha-
2,8-dien-1-ol to 81% against 35%, and the overall yield of desoxy-cannabidiol synthesis from 12% to
48%. Optimized transethosomes containing 0.6 mg/mL cannabinoids were prepared with 1:10 PG:lipid weight
ratio, 0.54 OA:lipid molar ratio, and 0.3 limonene:lipid molar ratio, showing good nanometric size (208 ± 20.8
nm - 321 ± 26.3 nm) and entrapment efficiency (> 80%). Ex-vivo tests showed both improved skin permeation
rates of cannabinoids (up to 21.32 ± 4.27 μg/cm2 cannabidiol), and skin penetration (depth of fluorescein up to
240 μm, with PG).

Conclusion:
Desoxy-cannabidiol was successfully produced at high yields, and formulated into transethosomes
optimized for transdermal delivery. Loaded vesicles showed improved skin penetration of desoxy-cannabidiol,
cannabidiol and a lipophilic probe. These results suggest the potential of these carriers for the transdermal
delivery of highly lipophilic drugs.