bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cilia from a cystic fibrosis patient react to the ciliotoxicPseudomonas aeruginosaII lectin in a similar manner to normal control cilia – a case report
Authors: Adam Elizabeth C. , Schumacher Dietlind U. , Schumacher Udo 
Published: November 2007

AbstractThe ciliary beat frequency measurements taken from a nasal polyp from a cystic fibrosis patient were similar to that of the control nasal polyps. The addition of a ciliotoxic lectin produced byPseudomonas aeruginosastopped the beating of the cilia as in the controls. This reaction could be blocked by the pre-incubation of the lectin with its inhibitor fucose. As in the control, the addition of fucose after the cilia had slowed resulted in a return to normal ciliary beating within 24 hours. This shows that the delta F508 CF mutation observed in this patient does not affect ciliary beating and suggests that treatment with fucose in the early stages of aPseudomonas aeruginosainfection could be advantageous for cystic fibrosis patients.
Autograft ossicle selection in cholesteatomatous ear disease: histopathological considerations
Authors: Rupa V. , Krishnaswami H. , Job A. 
Published: November 2007

AbstractIn order to determine whether selection of autograft ossicles in cholesteatomatous ear disease should be based on upon their apperance under the surgical operating microscope, we studied the histopathological features of 113 such ossicles. We attempted to correlate the extent of erosion of the ossicle, as noted under the surgical operating microscope, with their histopathological apperance. There were 60 mallei and 53 incudes. Seventy-nine ossicles were eroded and 34 were intact. The commonest abnormality noted was erosion of the long process of the incus (75 per cent). Both intact and eroded ossicles had similar histological features. There was no evidence of intra-ossicular cholesteatoma. The results suggest that the extent of erosion of these ossicles as seen under the surgical operating microscope should in no wasy prejudice their use as autografts when required.
Frey's syndrome: treatment with botulinum toxin
Authors: Bjerkhoel A. , Trobbe O. 
Published: November 2007

AbstractFrey's syndrome, i.e. gustatory sweating on the cheek, is a fairly common embarrassment after parotid gland surgery. New surgical techniques have been proposed to avoid this complication, but are not widely in use. Hence, there is need for treatment of Frey's syndrome. All surgical and topical treatments have drawbacks. This study was set up in order to evaluate a recently described treatment. One hundred and two patients were interviewed after parotidectomy. Thirty-one of them had noticed gustatory sweating and 15 patients underwent Minor's starch iodine test before, and after, treatment with intracutaneous injections of botulinum toxin A (Botox®, Allergan Inc., USA). Thirteen of the patients did not experience any gustatory sweating at follow-up (one to 13 months). Minor's starch test showed total disappearance of gustatory sweating in 12 of the 15 treated patients. The only side effect was a discreet, transitory affection of the orbicularis oris muscle in one patient. As this treatment is minimally invasive it could be an attractive treatment for Frey's syndrome if the effect is maintained. Complaints of local hypoaesthesia and pain were also common after parotid surgery.
Cochlear implantation in patients suffering from Cogan's syndrome
Authors: Cinamon Udi , Kronenberg Jona , Hildesheimer Minka , Taitelbaum Riki 
Published: November 2007

AbstractAmong patients who receive cochlear implants, those with Cogan's syndrome make a unique group. On one hand they are part of the post-lingual patients and good results can be anticipated. On the other hand, their basic illness is thought to have an autoimmune aetiology and for that reason more susceptible to complications, especially flap problems. In a series of 60 patients who were implantedat the Sheba Medical Center, three had Cogan's syndrome. No post-operative complications, including flap problems, were observed (followed-up for at least 18 months). Subjective and objective hearing results were very good.
Leishmania braziliensis presenting as a granulomatous lesion of the nasal septum mucosa
Authors: Lohuis P. J. F. M. , Lipovsky M. M. , Hoepelman A. I. M. , Hordijk G. J. , Huizing E. H. 
Published: November 2007

AbstractDifferential diagnosis of granulomatous lesions of the nasal mucosa is difficult. One of the possible causes is an infection with Leishmania braziliensis as reported in this case. Therefore leishmaniasis should be included in the differential diagnosis of granulomatous lesions of the nasal mucosa in patients who have travelled to endemic areas.
Endoscopic ligation or diathermy of the sphenopalatine artery in persistent epistaxis
Authors: Sharp H. R. , Rowe-Jones J. M. , Biring G. S. , Mackay I. S. 
Published: November 2007

AbstractConventional methods of arterial ligation in persistent epistaxis often involve significant surgical morbidity, as well as failure due to arterial anastomosis.We have performed endoscopic intranasal end ligation or diathermy of 11 sphenopalatine arteries in 10 patients with no complications and with no further episodes of epistaxis, with an average follow-up period of nine months.
Epstein-Barr virus BHRF1 prohibits the cells of nasopharyngeal carcinoma from apoptosis
Authors: Huang H. , Zhou J. H. , Zhou S. M. , Hu J. H. , Pan X. H. , Kong X. T. , Yu L. , Sun X. Y. , Wu W. 
Published: November 2007

AbstractEpstein-Barr virus (EBV) is associated with nasopharyngeal carcinoma (NPC). The BHRF1 EBV protein is expressed at high levels in productively infected cells and certain latently infected cells. In order to investigate the effect of expression of BHRF1 on the biological behaviour of NPC cells, we constructed the BHRF1 high expression vector and transfected it into the NPC cell line, CNE2. Then, the alteration of proliferation and apoptotic rates in the cells were tested before and after camptothecin treatment. After treatment by camptothecin, BHRF1-CNE2cells could constantly and slowly proliferate and its apoptotic rate was less than in control groups, and the number of cells in the G phase decreased and in the S phase increased. So, it suggests that BHRF1 expression can enhance the resistibility of CNE2cells to DNA damaging agents that cause apoptosis.
Acute food bolus impaction: aetiology and management
Authors: Lacy Peter D. , Donnelly Martin J. , McGrath Joseph P. , Byrne Patrick J. , Hennessy Thomas P. J. , Timon Conrad V. I. 
Published: November 2007

AbstractA prospective study into the aetiology of acute food bolus obstruction (AFBO) was carried out on 17 consecutive patients who presented with this complaint. There were nine males and eight females. Twelve patients (71 per cent) had symptoms of oesophageal disease and 10 patients (59 per cent) had prior food bolus obstruction. Investigations included endoscopy, barium swallow, oesophageal pH and manometry studies. Evidence of oesophageal pathology was found in 12/14 (86 per cent) of patients investigated. No patients had malignancy and the most common abnormality, gastroesophageal reflux (GOR) was found in eight out of 14 (57 per cent) of cases. Oesophageal dysmotility was seen in five out of 12 (42 per cent) patients who had manometric studies.With such a high incidence of recurrence of AFBO, we suggest that patients with this condition be investigated to exclude malignancy and to identify benign oesophageal pathology using techniques such as oesophageal pH and manometry. Appropriate treatment of oesophageal disease may help prevent recurrence of this distressing condition.
Asphyxial death caused by a laryngeal schwannoma: a case report
Authors: Gardner Patrick M. , Jentzen Jeffrey M. , Komorowski Richard A. , Harb Joseph M. 
Published: November 2007

AbstractNeurogenic tumours of the larynx are unusual, with approximately 115 cases reported in the literature to date. Most of these lesions are benign, solitary submucosal nodules which present with hoarseness and are amenable to surgical resection. We present a case of a large pedunculated schwannoma arising in the aryepiglottic fold associated with sudden asphyxial death in an otherwise healthy young female.
More about pain in the neck: thyroid cartilage and mastoid process syndromes
Authors: Hefer Tsila , Nir Dan , Joachims Henry Zvi 
Published: November 2007

AbstractEight patients with cervical pain were examined. The only positive finding was an impressive tenderness over the thyroid cartilage (in seven patients) or over the area of the insertion of the sternocleidomastoid muscle to the mastoid process (in one patient). The diagnosis of thyroid cartilage syndrome and mastoid process syndrome were suggested and the patients were treated with oral and topical non-steroidal anti-inflammatorydrugs (NSAIDs) which reduced the symptoms. These syndromes are rare. The thyroid cartilage syndrome has been previously reported only once in the literature and this is the firstreport on the mastoid process syndrome. These syndromes, although rare, should be included in the list of causes for cervical pain and better recognition of the syndromes will save patients from undergoing unnecessary investigation and inappropriate treatment.
Otolaryngological treatments in hagiographical Byzantine texts (324–1453 A.D.): miracles or reality?
Authors: Lascaratos John , Poulacou-Rebelacou E. , Yiotakis John 
Published: November 2007

AbstractHagiographical texts of the Byzantine period contain a significant number of miraculous treatments of several diseases of the ear, nose and throat. The comparison of the conservative treatments referred to as well as the often concealed surgical interventions of these texts with those known from the medical texts of the eminent Byzantine physicians, lead the writers to conclude that a series of real treatments were carried out in the churches or in the Xenones (hospitals) of Byzantium.
ENT day surgery in England and Wales – an audit by the Royal College of Surgeons (Eng.) Comparative Audit Service
Authors: Brown Peter M. , Fowler Sarah , Ryan Rowena , Rivron Raymond 
Published: November 2007

AbstractAn audit of day surgery was carried out by the Royal College of Surgeons (Eng.) Comparative Audit service. Data from 121 respondents on over 3 962 day cases were analysed from both retrospective information and from prospective individual patient proformas. The day surgery rate is 31 per cent. The variability of facilities for day-surgery, the timing of lists, type of anaesthetic used and case-mix are discussed. Outcome and the reasons for admission to an overnight bed are analysed. The overall admission rate was found to be 2.8 per cent (range 0.6–19.5 per cent between consultants). Seventy per cent of ENT day-surgery was performed on morning lists which have a lower admission rate than afternoon lists. The main reasons for admission are vomiting 30 per cent, haemorrhage 20 per cent and inadequate recovery from anaesthetic 22 per cent. A more detailed analysis of reasons for admission were given for tonsillectomy, adenoidectomy, FESS, and grommets. Recommendations are given which might increase the scope of safe day-surgery and reduce admission rate.
Craniofacial necrotizing fasciitis secondary to sinusitis
Authors: Raboso Eduardo , Llavero Maria T. , Rosell Antonio , Martinez-Vidal Antonio 
Published: November 2007

AbstractNecrotizing fasciitis is a rare condition which usuallyaffects the trunk, perineum and limbs. Head and neck involvement is very uncommon and in most cases it is secondary to orbital or dental infection. We report a case of craniofacial necrotizing fasciitis (CNF) secondary to a maxillary sinusitis. The patient was treated intensively with antibiotics, surgical procedures and life-support measures.Despite all efforts, the patient died one week after admission. This case highlights early diagnosis and aggressive management as decisivefactors for the outcome of the patient.
Oncogenic osteomalacia: case report and review of head and neck associated tumours
Authors: Gonzalez-Compta X. , Mañós-Pujol M. , Foglia-Fernandez M. , Peral E. , Condom E. , Claveguera T. , Dicenta-Sousa M. 
Published: November 2007

AbstractOncogenic osteomalacia is an uncommon syndrome characterized by mineral metabolism abnormalities that disappear after the resection of an associated tumour. Head and neck is the second most frequent location of these tumours. We describe a case with an ethmoido-frontal phosphaturic mesenchymal tumour and review oncogenic osteomalacia-associated tumours. Among 21 cases found, 57 per cent affected the sinonasal area and 20 per cent the mandible. The diagnosis of the tumour lasted a mean of 4.7 years from the onset of osteomalacia, and most of them showed a significant vascular component. An aggressive surgical approach is recommended.
A qualitative assessment of randomized controlled trials in otolaryngology
Authors: Ah-See K. W. , Molony N. C. 
Published: November 2007

AbstractIn 1996 the CONSORT statement made recommendations on the strict reporting of randomized controlled trials (RCT). This will facilitate the future assessment of such trials and will highlight those trials that have been performed suboptimally and whose results may be biased.We have devised a scoring system, based on CONSORT, to assess RCT quality and by reading each original paper in full we have now assessed the quality of trials published from 1966 to 1995.The mean score for trials identified was 7.3 out of a maximum 12 points. No one journal was significantly better than the others. Trials in rhinology are reported better than head and neck oncology trials (mean scores 7.6 and 6.5 respectively). The past 30 years has not seen an improvement in the quality of the trials.The reporting of RCTs in the ENT literature is poor. CONSORT guidelines now exist and trialists are encouraged to adopt them when conducting future clinical trials.
Carbon dioxide laser stomaplasty for tracheostomal stenosis
Authors: Sani A. 
Published: November 2007

AbstractA method of treating tracheostomal stenosis post-laryngectomy is described. The carbon dioxide (CO2) laser is used to fashion and ablate two triangular areas lateral to the stenosed stoma to provide an immediate enlarged stoma for comfortable breathing. This simple procedure is done under local anaesthesia, is almost bloodless, safe and takes just 10 minutes. Over the last five years eight patients underwent this procedure and seven had a satisfactory stoma without the need to use a tracheostomy tube.
Excision and low-dose radiotherapy for refractory laryngeal granuloma
Authors: Mitchell G. , Pearson C. R. , Henk J. M. , Rhys-Evans P. 
Published: November 2007

AbstractLaryngeal granulomas are uncommon lesions of an inflammatory origin. They are conventionally managed by simple excision with the occasional use of adjuvant treatment depending on the aetiological factors. Unfortunately, recurrences can occur, requiring repeated excision. Some lesions are refractory to this approach and alternative management approaches include excision and immediate adjuvant radiotherapy. The use of radiotherapy in the management of benign disease can be limited by the risk of induction of late malignancy and informed consent of a patient must include an assessment of this risk. We describe a case of refractory laryngeal granuloma successfully treated by excision and immediate radiotherapy in a patient occupationally dependent upon his voice.
How long should ears be bandaged after otoplasty?
Authors: Bartley J. 
Published: November 2007

AbstractA firm head dressing is usually applied after otoplasty. Some surgeons recommend that the patient should wear the bandage for up to 10 days after surgery. However, these bandages are frequently displaced or come off. Patients complain of reduced hearing, itch and the smell of old blood in the bandages. A case series of 52 patients undergoing bilateral otoplasty who had a head bandage on for only 24 hours was audited prospectively. Minor complications occurred in two patients. A head bandage does not need to remain on for more than 24 hours after otoplasty.
Closure of the nasal vestibule in atrophic rhinitis – a new non-surgical technique
Authors: Lobo C. J. , Hartley C. , Farrington W. T. 
Published: November 2007

AbstractA new technique is described for closing the nasal vestibule in cases of secondarily-acquired atrophic rhinitis. This involves occlusion of the nasal vestibule with an obturator made from dimethylpolysiloxane. Being a non-invasive method it is specifically indicated in the management of cases of secondarily-acquired atrophic rhinitis where any surgical treatment is contra-indicated. We describe its use in a case each of unilateral and bilateral secondary atrophic rhinitis.
The management of massive pneumocephalus and cerebrospinal fluid rhinorrhoea as a consequence of biopsy in a patient with inverted papilloma
Authors: Kale U. S. , Raje S. G. , Wight R. G. 
Published: November 2007

AbstractNasal polypectomy is a common ENT operation. Cerebrospinal fluid (CSF) rhinorrhoea and pneumocephalus are rare complications. We present a patient who developed both these complications after biopsy of nasal polyps which subsequently proved to be an inverted papilloma. He had a defect in the ethmoid roof, which was repaired.Whilst endoscopic repair of CSF leak is increasing in popularity, in this patient because of his pathology and difficulty of access a more traditional lateral rhinotomy approach was made with a successful outcome. An overview of the management of these complications is presented.
Intralaryngotracheal thyroid – ectopic thyroid or invasive carcinoma?
Authors: See Andrew C. H. , Patel Snehal G. , Montgomery Paul Q. , Evans Peter H. Rhys , Fisher Cyril 
Published: November 2007

AbstractIntralaryngotracheal thyroid is a rare clinical condition with only about 125 cases described so far in the literature. We present an unusual case of intralaryngotracheal thyroid which had many clinical features of malignancy and yet appeared benign on histology. As in this case, well-differentiated thyroid cancer can present with locally aggressive clinical features and can pose a dilemma in management if treatment decisions are guided solely by histological features.
Teratocarcinosarcoma of the nasal cavity and ethmoid
Authors: Sharma Hari Shankar , Abdullah Jafri Malin , Othman Nor Hayati , Muhamad Mahayidin 
Published: November 2007

AbstractSinonasal teratocarcinosarcoma is very unusual malignant neoplasm histologically consisting of an epithelial element and one or more mesenchymal components. This is a report of teratocarcinosarcoma, in a 74-year-old male, involving the right nasal cavity and ethmoids with intracranial extension. The tumour was totally resected via the craniofacial approach and the patient was given post-operative chemotherapy. Extensive tumour necrosis, rapid growth and local destruction are the prominent features of this tumour. The clinical presentation, pathological features and clinical course of this rare malignancy are discussed with a review of the literature.
Epithelial atypia and squamous metaplasia in nasal polyps
Authors: Baird A. R. , Hilmi O. , White P. S. , Robertson A. J. 
Published: November 2007

AbstractFifteen routine nasal polypectomy specimens submitted to our laboratory over an eight-month period were noted to show marked atypia within areas of squamous metaplasia to a degree suggestive of dysplasia. Reviewing the literature revealed little published work in this area, especially recently. Further nasal polyp cases from this, and a similar previous time period, were re-examined, and possible causes for these changes discussed.
Angiolymphoid hyperplasia with eosinophilia of the parapharyngeal space
Authors: Backhouse S. S. , Shone G. R. , Douglas-Jones A. G. 
Published: November 2007

AbstractAngiolymphoid hyperplasia with eosinophilia (ALHE) is an uncommon benign condition characterized by cutaneous nodules with a predeliction for the head and neck region. Extracutaneous involvement is rare. We report a 44-year-old woman who had a large submucosal ALHE tumour in the parapharyngeal space. Our patient is of interest because of the unusual, and as far as we are aware from the literature, unique site and presentation of her lesion.
Mucoceles of the paranasal sinuses: uncommon location
Authors: Arrué P. , Kany M. Thorn , Serrano E. , Lacroix F. , Percodani J. , Yardeni E. , Pessey J. J. , Manelfe C. 
Published: November 2007

AbstractMucoceles are the most common lesions causing expansion of the paranasal sinuses. The sinuses most commonly involved are, in decreasing order of frequency, frontal sinus, ethmoid sinuses, maxillary sinus and sphenoid sinus. We reviewed 46 cases of surgically proven mucoceles and the purpose of this study was to report five cases of mucoceles in an uncommon location.
Needle myringotomy: a useful technique with the increased prevalence of the human immunodeficiency virus
Authors: Thorp M. A. 
Published: November 2007

AbstractMyringotomy is one of the most common procedures performed by ENT surgeons. Use of the tip of a hypodermic needle not only provides a neat and precise incision into the tympanic membrane, but is also a cheap and disposable means of doing so. Sterility is virtually guaranteed avoiding any possibility of cross contamination between consecutive patients.
Histological features and prognosis of patients with mucoepidermoid carcinoma of the parotid gland
Authors: Suzuki Masashi , Ichimiya Issei , Matsushita Futoshi , Mogi Goro 
Published: November 2007

AbstractHistological features and prognosis of patients with mucoepidermoid carcinoma of the parotid gland were analysed. Tumours from 13 patients were classified according to histological grades and immunoreactivity for HEK-2/neu. Surgical resection of the tumour was performed for all patients, and the overall five-year survival rate was 69 per cent. The patients whose histological grades were 1 or 2 showed a 100 per cent five-year survival rate, but no patient with grade 3 survived five years. Also, patients who had tumours that overexpressed HER-2/new had a lower survival rate (25 per cent) than patients with tumours that had weaker immunostaining (89 per cent). We considered tumours classified as grade 3 plus strong HER-2/neu expression to be ‘high malignancy’, and compared them with ‘low malignancy’ tumours that were grade 1 or 2 and had weaker HER-2/new staining. Patients with high malignancy tumours had shorter recurrence-free intervals and shorter overall survival than patients with low malignancy tumours. The overall survival period of the low malignancy cases was much longer than the recurrence-free interval; unlike that in the high malignancy tumour patients. These results suggest that the combination of histological grades and expression of HER-2/neu may be a useful predictor of the prognosis for mucoepidermoid carcinomata.
Sudden hearing loss in a patient hepatitis C virus (HCV) positive on therapy with alpha-interferon: a possible autoimmune-microvascular pathogenesis
Authors: Cadoni G. , Marinelli L. , De Santis A. , Romito A. , Manna R. , Ottaviani F. 
Published: November 2007

AbstractAlpha interferon (α-IFN) is used for the treatment of various systemic disorders. Side-effects of α-IFN therapy can involve numerous organ systems, but sudden hearing loss has only once been recorded. We report a case of sudden hearing loss occurring in a patient with chronic hepatitis C treated with α-IFN and recovered five days after the discontinuation of this agent. This is the first record of anti-endothelial cell antibodies detection in a patient with sudden hearing loss. The finding of anti-endothelial cell antibodies suggests an association between sudden hearing loss and microvascular damage during interferon therapy.