bluuebunny/crossref_metadata_2025_split huggingface dataset:
Indicators of cure for women living after uterine and ovarian cancers: a population-based study
Authors: Giudici Fabiola , De Paoli Angela , Toffolutti Federica , Guzzinati Stefano , Francisci Silvia , Bucchi Lauro , Gatta Gemma , Demuru Elena , Mallone Sandra , Cin Antonella Dal , Caldarella Adele , Cuccaro Francesco , Migliore Enrica , Gambino Maria Letizia , Ravaioli Alessandra , Puppo Antonella , Ferrante Margherita , Carrozzi Giuliano , Stracci Fabrizio , Musolino Antonino , Gasparotti Cinzia , Cavallo Rossella , Mazzucco Walter , Vitale Maria Francesca , Cascone Giuseppe , Ballotari Paola , Ferretti Stefano , Mangone Lucia , Rizzello Roberto Vito , Sampietro Giuseppe , Mian Michael , Boschetti Lorenza , Galasso Rocco , Bella Francesca , Piras Daniela , Sessa Alessandra , Seghini Pietro , Fanetti Anna Clara , Pinna Pasquala , De Angelis Roberta , Serraino Diego , Maso Luigino Dal ,   AIRTUM working group, Crocetti Emanuele , Rossi Silvia , Tavilla Andrea , Botta Laura , Contiero Paolo , Tagliabue Giovanna , Capocaccia Riccardo , Rugge Massimo , Manneschi Gianfranco , Bruno Danila , Rosso Stefano , Taborelli Martina , Lanzoni Monica , Falcini Fabio , Casella Claudia , Di Prima Alessia , Cirilli Claudia , Bianconi Fortunato , Michiara Maria , Maifredi Giovanni , Frasci Giuseppe , Ravazzolo Barbara , Fusco Mario , Rollo Concetta Patrizia , Giacomazzi Erica , Bisceglia Isabella , Adalgisa Maria , Ghisleni Silvia , Vittadello Fabio , Marguati Stefano , Del Riccio Luciana , Colanino Antonino Ziino , Biddau Giovanna , Merola Maddalena , Prazzoli Rita , Giumelli Paola , Bosu Roberta 
Published: April 2024

Abstract
This study aims to estimate long-term survival, cancer prevalence, and several cure indicators for Italian women with gynecological cancers. Thirty-one cancer registries, representing 47% of the Italian female population, were included. Mixture cure models were used to estimate net survival, cure fraction, time to cure (when 5-year conditional net survival becomes &gt; 95%), cure prevalence (women who will not die of cancer), and already cured (living longer than time to cure). In 2018, 0.4% (121 704) of Italian women were alive after diagnosis of corpus uteri cancer, 0.2% (52 551) after cervical cancer, and 0.2% (52 153) after ovarian cancer. More than 90% of patients with uterine cancers and 83% with ovarian cancer will not die from their neoplasm (cure prevalence). Women with gynecological cancers have a residual excess risk of death &lt;5% at 5 years after diagnosis. The cure fraction was 69% for corpus uteri, 32% for ovarian, and 58% for cervical cancer patients. Time to cure was ≤10 years for women with gynecological cancers aged &lt;55 years; 74% of patients with cervical cancer, 63% with corpus uteri cancer, and 55% with ovarian cancer were already cured. These results can contribute to improving follow-up programs for women with gynecological cancers and supporting efforts against discrimination of already cured ones.
This article is part of a Special Collection on Gynecological Cancers.
Well-spread samples with dynamic sample sizes
Authors: Robertson Blair , Price Chris , Reale Marco 
Published: April 2024

ABSTRACTA spatial sampling design determines where sample locations are placed in a study area so that population parameters can be estimated with relatively high precision. If the response variable has spatial trends, spatially balanced or well-spread designs give precise results for commonly used estimators. This article proposes a new method that draws well-spread samples over arbitrary auxiliary spaces and can be used for master sampling applications. All we require is a measure of the distance between population units. Numerical results show that the method generates well-spread samples and compares favorably with existing designs. We provide an example application using several auxiliary variables to estimate total aboveground biomass over a large study area in Eastern Amazonia, Brazil. Multipurpose surveys are also considered, where the totals of aboveground biomass, primary production, and clay content (3 responses) are estimated from a single well-spread sample over the auxiliary space.
Assessing the utility of natural language processing for detecting postoperative complications from free medical text
Authors: Dencker Emilie Even , Bonde Alexander , Troelsen Anders , Sillesen Martin 
Published: April 2024

Abstract

Background
Postoperative complication rates are often assessed through administrative data, although this method has proven to be imprecise. Recently, new developments in natural language processing have shown promise in detecting specific phenotypes from free medical text. Using the clinical challenge of extracting four specific and frequently undercoded postoperative complications (pneumonia, urinary tract infection, sepsis, and septic shock), it was hypothesized that natural language processing would capture postoperative complications on a par with human-level curation from electronic health record free medical text.

Methods
Electronic health record data were extracted for surgical cases (across 11 surgical sub-specialties) from 18 hospitals in the Capital and Zealand regions of Denmark that were performed between May 2016 and November 2021. The data set was split into training/validation/test sets (30.0%/48.0%/22.0%). Model performance was compared with administrative data and manual extraction of the test data set.

Results
Data were obtained for 17 486 surgical cases. Natural language processing achieved a receiver operating characteristic area under the curve of 0.989 for urinary tract infection, 0.993 for pneumonia, 0.992 for sepsis, and 0.998 for septic shock, whereas administrative data achieved a receiver operating characteristic area under the curve of 0.595 for urinary tract infection, 0.624 for pneumonia, 0.571 for sepsis, and 0.625 for septic shock.

Conclusion
The natural language processing approach was able to capture complications with acceptable performance, which was superior to administrative data. In addition, the model performance approached that of manual curation and thereby offers a potential pathway for complete real-time coverage of postoperative complications across surgical procedures based on natural language processing assessment of electronic health record free medical text.
Ectogestation and Humanity’s Whence? An Exploration with Saint Augustine and Karl Barth
Authors: Anderson Matthew Lee 
Published: April 2024

Abstract
This essay explores the theological and anthropological significance of birth, in order to discern what might be lost with the adoption of complete ectogestation (“artificial wombs”). Specifically, it considers both Saint Augustine and Karl Barth’s respective accounts of humanity’s whence—that is, their theological answer to the question of the nature and significance of our origins as individuals. I suggest that Augustine’s account of his origins emphasizes both his epistemic and biological dependency on his mother and nurses, while Barth’s stresses the individual’s immediate derivation from God. Those disparate answers affect how they construe the relationships of parents and children and work themselves throughout their theological visions and imaginations. I conclude that careful consideration of humanity’s whence cannot answer whether we ought to pursue ectogestation; but it does help us account for how our understanding of God and ourselves might be altered if we gestate human life outside the womb.
The Application of the Principle of Common but Differentiated Responsibilities in Environmental Governance on the High Seas
Authors: Yong Wang , Xin Pan 
Published: April 2024

Abstract
As an important principle of international environmental law, the principle of common but differentiated responsibilities (the CBDR principle) is being applied to various international environment protection regimes including environmental governance on the high seas as an important guiding principle in the law of the sea. This may be beneficial for engaging the international community to protect the high seas in solidarity. However, the application of the CBDR principle encounters difficulties, which include obstacles regarding cross-sector application, different understandings of the CBDR principle and difficulties in implementation of international instruments. This article argues that the differentiation should not depend exclusively on the traditional dichotomy of developing and developed countries but must be determined on a fluid and case-by-case basis. This suggests that the details of the differentiated responsibilities should also be context-specific rather than uniform for all States. Moreover, the implementation of the CBDR principle to address environmental problems on the high seas should be based on substantive fairness. Finally, this article makes several observations. First, the demands of developing countries in the field of maritime emission reduction should be considered. Second, obligation of capacity building and the transfer of marine technology prescribed in the BBNJ Agreement should be encouraged and implemented. Third, strengthening international cooperation in plastic pollution control on the high seas is expected. Fourth, the international community should provide developing countries with the financial support and technical assistance in persistent organic pollutants control. All of these may contribute to the protection of the high seas environment and the future realization of the sustainable development of the oceans.
Sharing News Left and Right: Frictions and Misinformation on Twitter
Authors: Ershov Daniel , Morales Juan S 
Published: April 2024

Abstract
On 20 October 2020, prior to the US presidential election, Twitter modified its user interface for sharing social media posts. In an effort to reduce the spread of misinformation on the platform, the new interface nudged users to be thoughtful about the content they were sharing. Using data on over 160,000 tweets by US news media outlets, we show that this policy significantly reduced news sharing, but that the reductions varied heterogeneously by political slant: sharing of content fell significantly more for left-wing outlets relative to right-wing outlets. Examining Twitter activity data for news-sharing users, we find that conservatives were less responsive to Twitter’s intervention. Lastly, using web traffic data, we document that the policy significantly reduced visits to news media outlets’ websites.
Variability of human Alpha-1-acid glycoprotein N-glycome in a Caucasian population
Authors: Vučković Frano , Novokmet Mislav , Šoić Dinko , Štambuk Jerko , Kolčić Ivana , Polašek Ozren , Lauc Gordan , Gornik Olga , Keser Toma 
Published: April 2024

Abstract

Aim
Alpha-1-acid glycoprotein (AGP) is a highly glycosylated protein in human plasma and one of the most abundant acute phase proteins in humans. Glycosylation plays a crucial role in its biological functions, and alterations in AGP N-glycome have been associated with various diseases and inflammatory conditions. However, large-scale studies of AGP N-glycosylation in the general population are lacking.

Methods
Using recently developed high-throughput glycoproteomic workflow for site-specific AGP N-glycosylation analysis, 803 individuals from the Croatian island of Korcula were analyzed and their AGP N-glycome data associated with biochemical and physiological traits, as well as different environmental factors.

Results
After regression analysis, we found that AGP N-glycosylation is strongly associated with sex, somewhat less with age, along with multiple biochemical and physiological traits (e.g. BMI, triglycerides, uric acid, glucose, smoking status, fibrinogen).

Conclusion
For the first time we have extensively explored the inter-individual variability of AGP N-glycome in a general human population, demonstrating its changes with sex, age, biochemical, and physiological status of individuals, providing the baseline for future population and clinical studies.
Regulatory role of Prunus mume DAM6 on lipid body accumulation and phytohormone metabolism in the dormant vegetative meristem
Authors: Hsiang Tzu-Fan , Yamane Hisayo , Gao-Takai Mei , Tao Ryutaro 
Published: April 2024

Abstract
Bud dormancy is a crucial process in the annual growth cycle of woody perennials. In Rosaceae fruit tree species, DORMANCY-ASSOCIATED MADS-box (DAM) transcription factor genes regulating bud dormancy have been identified, but their molecular roles in meristematic tissues have not been thoroughly characterized. In this study, molecular and physiological analyses of transgenic apple plants overexpressing the Japanese apricot DAM6 gene (PmDAM6) and Japanese apricot cultivars and F1 individuals with contrasting dormancy characteristics revealed the metabolic pathways controlled by PmDAM6. Our transcriptome analysis and transmission electron microscopy examination demonstrated that PmDAM6 promotes the accumulation of lipid bodies and inhibits cell division in the dormant vegetative meristem by down-regulating the expression of lipid catabolism genes (GDSL ESTERASE/LIPASE and OIL BODY LIPASE) and CYCLIN genes, respectively. Our findings also indicate PmDAM6 promotes abscisic acid (ABA) accumulation and decreases cytokinin (CTK) accumulation in vegetative buds by up-regulating the expression of the ABA biosynthesis gene ARABIDOPSIS ALDEHYDE OXIDASE and the CTK catabolism gene CYTOKININ DEHYDROGENASE, while also down-regulating the expression of the CTK biosynthesis genes ISOPENTENYL TRANSFERASE (IPT) and CYP735A. Additionally, PmDAM6 modulates gibberellin (GA) metabolism by up-regulating GA2-OXIDASE expression and down-regulating GA3-OXIDASE expression. Furthermore, PmDAM6 may also indirectly promote lipid accumulation and restrict cell division by limiting the accumulation of CTK and GA in buds. In conclusion, using our valuable genetic platform, we clarified how PmDAM6 modifies diverse cellular processes, including lipid catabolism, phytohormone (ABA, CTK, and GA) biosynthesis and catabolism, and cell division, in the dormant vegetative meristem.
Between Accountability and Reconciliation: The Making of “the Victim-Centered Approach” at the International Criminal Court
Authors: Shimoyachi Nao 
Published: April 2024

AbstractThe International Criminal Court is the first international court to have incorporated the newly recognized right of victims to redress. However, there remains considerable skepticism about how the ICC and, more broadly, international criminal justice serve the purposes of victim redress. This article examines the development of the ICC’s reparations policy from the standpoint of how constitutive rules of international criminal justice have been changed. It illustrates how conflicting views regarding victim reparations have formed different preferences within the institution, even among the judiciary. Unlike existing studies that tend to regard the ICC as a monolithic law enforcement institution, this article demonstrates that the victim-centered approach to reparations at the ICC is a compromise between two models: an accountability model that tries to confine the scope of reparations within the clearly defined liability of the convicted person; and a reconciliation model that aims at reaching a large number of victims to facilitate the rehabilitation of the community. The finding has two implications. First, although the study reveals severe tensions between individual accountability and social reconciliation, the tensions can be reconciled through creative judgments. Second, related to the first implication, the ICC is not just a law enforcement institution, but also a policymaking institution, which has considerable leeway in designing reparations policy.
Loss-of-function OGFRL1 variants identified in autosomal recessive cherubism families
Authors: Kittaka Mizuho , Mizuno Noriyoshi , Morino Hiroyuki , Yoshimoto Tetsuya , Zhu Tianli , Liu Sheng , Wang Ziyi , Mayahara Kotoe , Iio Kyohei , Kondo Kaori , Kondo Toshio , Hayashi Tatsuhide , Coghlan Sarah , Teno Yayoi , Doan Andrew Anh Phung , Levitan Marcus , Choi Roy B , Matsuda Shinji , Ouhara Kazuhisa , Wan Jun , Cassidy Annelise M , Pelletier Stephane , Nampoothiri Sheela , Urtizberea Andoni J , Robling Alexander G , Ono Mitsuaki , Kawakami Hideshi , Reichenberger Ernst J , Ueki Yasuyoshi 
Published: April 2024

Abstract
Cherubism (OMIM 118400) is a rare craniofacial disorder in children characterized by destructive jawbone expansion due to the growth of inflammatory fibrous lesions. Our previous studies have shown that gain-of-function mutations in SH3 domain-binding protein 2 (SH3BP2) are responsible for cherubism and that a knock-in mouse model for cherubism recapitulates the features of cherubism, such as increased osteoclast formation and jawbone destruction. To date, SH3BP2 is the only gene identified to be responsible for cherubism. Since not all patients clinically diagnosed with cherubism had mutations in SH3BP2, we hypothesized that there may be novel cherubism genes and that these genes may play a role in jawbone homeostasis. Here, using whole exome sequencing, we identified homozygous loss-of-function variants in the opioid growth factor receptor like 1 (OGFRL1) gene in 2 independent autosomal recessive cherubism families from Syria and India. The newly identified pathogenic homozygous variants were not reported in any variant databases, suggesting that OGFRL1 is a novel gene responsible for cherubism. Single cell analysis of mouse jawbone tissue revealed that Ogfrl1 is highly expressed in myeloid lineage cells. We generated OGFRL1 knockout mice and mice carrying the Syrian frameshift mutation to understand the in vivo role of OGFRL1. However, neither mouse model recapitulated human cherubism or the phenotypes exhibited by SH3BP2 cherubism mice under physiological and periodontitis conditions. Unlike bone marrow-derived M-CSF-dependent macrophages (BMMs) carrying the SH3BP2 cherubism mutation, BMMs lacking OGFRL1 or carrying the Syrian mutation showed no difference in TNF-ɑ mRNA induction by LPS or TNF-ɑ compared to WT BMMs. Osteoclast formation induced by RANKL was also comparable. These results suggest that the loss-of-function effects of OGFRL1 in humans differ from those in mice and highlight the fact that mice are not always an ideal model for studying rare craniofacial bone disorders.
Virtual-Trim: A parametric geometric modeling method for heterogeneous strut-based lattice structures
Authors: Li Zhuangyu , Xiao Wenlei , Zhao Gang , Zhou Ziqi , Chen Shulin , Xiong Changri 
Published: April 2024

Abstract
Geometric modeling has been integral to the design process with the introduction of Computer-Aided Design. With additive manufacturing (AM), design freedom has reached new heights, allowing for the production of complex lattice structures not feasible with traditional manufacturing methods. However, there remains a significant challenge in the geometric modeling of these lattice structures, especially for heterogeneous strut-based lattice structures. Current methods show limitations in accuracy or geometric control. This paper presents the Virtual-Trim, a novel method for the geometric modeling of heterogeneous strut-based lattice structures that is both efficient and robust. Virtual-Trim begins with user-defined wireframe models and geometric information to create STL (STereoLithography) models ready for AM, eliminating the need for labor-intensive Boolean operations. The fundamental principles and steps involved in Virtual-Trim are extensively described within. Additionally, various models using Virtual-Trim method are designed, and the performance of Virtual-Trim in terms of generation time and model size is analyzed. The successful printing of these models attests to the method’s excellent manufacturability.
How AI challenges the medical device regulation: patient safety, benefits, and intended uses
Authors: Onitiu Daria , Wachter Sandra , Mittelstadt Brent 
Published: April 2024

Abstract
This article examines whether the EU Medical Device Regulation (MDR) adequately addresses the novel risks of AI-based medical devices (AIaMDs), focusing on AI medical imaging tools. It examines two questions: first, does the MDR effectively deal with issues of adaptability, autonomy, bias, opacity, and the need of trustworthiness of AIaMD? Second, does the manufacturer’s translation of the MDR’s requirements close a discrepancy between an AIaMDs’ expected benefit and the actual clinical utility of assessing device safety and effectiveness beyond the narrow performance of algorithms? While the first question has previously received attention in scholarly literature on regulatory and policy tensions on AIaMD generally, and work on future technical standard setting, the second has been comparatively overlooked. We argue that effective regulation of AIaMD requires framing notions of patient safety and benefit within the manufacturer’s articulation of the device’s intended use, as well as reconciling tensions. These tensions are on (i) patient safety and knowledge gaps surrounding fairness, (ii) trustworthiness and device effectiveness, (iii) the assessment of clinical performance, and (iv) performance updates. Future guidance needs to focus on the importance of translated benefits, including nuanced risk framing and looking at how the limitations of AIaMD inform the intended purpose statement in the MDR.
Advances in imaging modalities for spinal tumors
Authors: Takamiya Soichiro , Malvea Anahita , Ishaque Abdullah H , Pedro Karlo , Fehlings Michael G 
Published: April 2024

Abstract
The spinal cord occupies a narrow region and is tightly surrounded by osseous and ligamentous structures; spinal tumors can damage this structure and deprive patients of their ability to independently perform activities of daily living. Hence, imaging is vital for the prompt detection and accurate diagnosis of spinal tumors, as well as determining the optimal treatment and follow-up plan. However, many clinicians may not be familiar with the imaging characteristics of spinal tumors due to their rarity. In addition, spinal surgeons might not fully utilize imaging for the surgical planning and management of spinal tumors because of the complex heterogeneity of these lesions. In the present review, we focus on conventional and advanced spinal tumor imaging techniques. These imaging modalities include computed tomography, positron emission tomography, digital subtraction angiography, conventional and microstructural magnetic resonance imaging, and high-resolution ultrasound. We discuss the advantages and disadvantages of conventional and emerging imaging modalities, followed by an examination of cutting-edge medical technology to complement current needs in the field of spinal tumors. Moreover, machine learning and artificial intelligence are anticipated to impact the application of spinal imaging techniques. Through this review, we discuss the importance of conventional and advanced spinal tumor imaging, and the opportunity to combine advanced technologies with conventional modalities to better manage patients with these lesions.