bluuebunny/crossref_metadata_2025_split huggingface dataset:
One‐Step Formed Janus Hydrogel with Time‐Space Regulating Properties for Suture‐Free and High‐Quality Tendon Healing
Authors: Ouyang Chenguang , Tu Tian , Yu Haojie , Wang Li , Ni Zhipeng , Yang Jian , Dong Yanzhao , Zou Xiaodi , Zhou Weijie , Liu Jinyi , Chen Dingning , Wang Yu , Wu Xudong , Yi Hong , Yuan Xunchun , Liu Zhenfeng , Lu Hui 
Published: February 2025

AbstractJanus hydrogels have promising applications in tendon healing and anti‐peritendinous adhesions. However, their complicated preparation methods, weak mechanical properties, and unstable adhesion interfaces have severely limited their application in suture‐free and high‐quality tendon healing. In this work, by controlling the interfacial distribution of free ‐COOH groups and cationic‐π structures on both sides of the hydrogels, a series of PZBA‐EGCG‐ALC Janus hydrogels with varying degrees of asymmetric properties are successfully prepared using a simple and efficient one‐step synthesis method. The tensile strength and elongation at the break of the Janus hydrogel are as high as 0.51 ± 0.04 MPa and 922.89 ± 28.59%. In addition, the Janus hydrogel can achieve a high difference in adhesion strength (nearly 20‐fold) while maintaining a strong adhesion strength on their bottom sides (up to 524.8 ± 33.1 J m−2). In the spatial dimension, its excellent mechanical compliance and one‐sided adhesion behavior can provide effective mechanical support and physical barriers for the injured Achilles tendons. More importantly, the Janus hydrogel can also minimize early inflammation generation in the time dimension via its ROS‐responsive PZBA‐EGCG prodrug macromolecules. This study provided a more effective and convenient suture‐free strategy for constructing Janus hydrogels to promote high‐quality tendon healing.
Data‐Driven Theoretical Modeling of Centrifugal Step Emulsification and Its Application in Comprehensive Multiscale Analysis
Authors: Wang Xin , Cai Xiaolu , Wan Chao , Yuan Huijuan , Li Shunji , Zhang Yiwei , Zhao Ran , Qin Yuxi , Li Yiwei , Liu Bi‐Feng , Chen Peng 
Published: February 2025

AbstractTailored droplet generation is crucial for droplet microfluidics that involve samples of varying sizes. However, the absence of precise predictive models forces droplet platforms to rely on empiricism derived from extensive experiments, underscoring the need for comprehensive modeling analysis. To address this, a novel customized assembled centrifugal step emulsifier (CASE) is presented by incorporating a “jigsaw puzzles” design to efficiently acquire large‐scale experimental data. Numerical simulations are utilized to analyze fluid configurations during step emulsification, identifying a key connection tube that determines droplet size. By training and verifying with the experimental and simulation datasets, a comprehensive theoretical model is established that allows for the preliminary design of the droplet size and generation frequency with an average error rate of 4.8%, successfully filling a critical gap in existing field. This predictive model empowers the CASE to achieve all‐in‐one functionality, including droplet pre‐design, generation, manipulation, and on‐site detection. As a proof of concept, multiscale sample analysis ranging from nanoscale nucleic acids to microscale bacteria and 3D cell spheroids is realized in the CASE. In summary, this platform offers valuable guidance for customized droplet generation by centrifugal step emulsifiers and promotes the adoption of droplet microfluidics in biochemical assays.
Targeting the E Prostanoid Receptor EP4 Mitigates Cardiac Fibrosis Induced by β‐Adrenergic Activation
Authors: Xu Hu , Mao Xiuhui , Wang Yali , Zhu Chunhua , Liang Bo , Zhao Yihang , Zhou Mengfei , Ye Lan , Hong Mengting , Shao Huishu , Wang Yashuo , Li Haonan , Qi Yinghui , Yang Yongliang , Chen Lihong , Guan Youfei , Zhang Xiaoyan 
Published: February 2025

AbstractSustained β‐adrenergic activation induces cardiac fibrosis characterized by excessive deposition of extracellular matrix (ECM). Prostaglandin E2 (PGE2) receptor EP4 is essential for cardiovascular homeostasis. This study aims to investigate the roles of cardiomyocyte (CM) and cardiac fibroblast (CF) EP4 in isoproterenol (ISO)‐induced cardiac fibrosis. By crossing the EP4f/f mice with α‐MyHC‐Cre or S100A4‐Cre mice, this work obtains the CM‐EP4 knockout (EP4f/f‐α‐MyHCCre+) or CF‐EP4 knockout (EP4f/f‐S100A4Cre+) mice. The mice of both genders are subcutaneously injected with ISO (5 mg kg−1 day−1) for 7 days. Compared to the control mice, both EP4f/f‐α‐MyHCCre+ and EP4f/f‐S100A4Cre+ mice show a significant improvement in cardiac diastolic function and fibrosis as assessed by echocardiography and histological staining, respectively. In the CMs, inhibition of EP4 suppresses ISO‐induced TGF‐β1 expression via blocking the cAMP/PKA pathway. In the CFs, inhibition of EP4 reversed TGF‐β1‐triggers production of ECM via preventing the formation of the TGF‐β1/TGF‐β receptor complex and blocks CF proliferation via suppressing the ERK1/2 pathway. Furthermore, double knockout of the CM‐ and CF‐EP4 or administration of EP4 antagonist, grapiprant, markedly improves ISO‐induced cardiac diastolic dysfunction and fibrosis. Collectively, this study demonstrates that both CM‐EP4 and CF‐EP4 contribute to β‐adrenergic activation‐induced cardiac fibrosis. Targeting EP4 may offer a novel therapeutic approach for cardiac fibrosis.
Wearable Self‐Powered Pressure Sensors Based on alk‐Ti3C2Tx Regulating Contact Barrier Difference for Noncontact Motion Object Recognition
Authors: Xiao Yanan , Pu Qi , Wang Chenxing , Jia Xiaoteng , Sun Shixiang , Jin Quan , Wang Xiaolong , Wang Bin , Sun Peng , Liu Fangmeng , Lu Geyu 
Published: February 2025

AbstractWearable self‐powered pressure sensors present tremendous potential for object recognition. However, the fluctuated approach speed and distance may compromise the device output, thus affecting the recognition accuracy. Herein, a wearable self‐powered pressure sensor with high sensitivity (1.48 V kPa−1), high output (130.5V), and high permeability (259.98 mm s−1) are developed where the contact barrier difference and triboelectric charge density of the triboelectric layer surface are dynamically regulated by modulating the surface groups resulting in a lower dielectric loss and higher output. The sensor leverages the polarity difference between the target object and the sensitive material to generate electrical signals at different speeds and distances through an electrostatic induction mechanism. With the assistance of the Transformer model with a self‐attention mechanism, an average recognition accuracy of 94.3% is achieved by acquiring sensing signals at different speeds and distances. Simulating the ability of human vision, enables visually impaired people to acclimate to their surroundings more easily and independently and provides a critical advancement in the assistance of the blind with daily life.
A Rapid Cortical Learning Process Supporting Students’ Knowledge Construction During Real Classroom Teaching
Authors: Feng Xiaodan , Xu Xinran , Meng Zhaonan , Jiang Jiahao , Pei Miao , Zheng Yonghe , Lu Chunming 
Published: February 2025

AbstractClassroom teaching is essential for cognitive development and cultural evolution, yet its neurocognitive mechanisms remain unclear. Here, this is explored in a university graduate course by combining wearable functional near‐infrared spectroscopy (fNIRS) and machine learning models. The results show that blended teaching involving both students’ recalling and teachers’ lecturing leads to better learning outcomes than lecturing alone. Moreover, during the same lecturing phase, blended teaching induces knowledge construction in the middle frontal cortex (MFC), while lecturing alone induces knowledge representation in the right temporoparietal junction (TPJ), with the former significantly correlating with the final learning outcomes. Additionally, the MFC's construction begins during earlier recalling but is significantly facilitated by later lecturing. Finally, when teacher's TPJ activity precedes that of students’ MFC, significant teacher–student neural synchronization is observed during lecturing of blended teaching and is correlated with learning outcomes. These findings suggest that, in the real classroom teaching, the MFC serves as a hub of a rapid cortical learning process, supporting knowledge construction through a projection from the teacher's TPJ.
The Origin of Li2S2 Reduction Mechanism Modulated by Single‐Atom Catalyst for all Solid‐State Li‐S Batteries
Authors: He Miao , Fan Yuxing , Liu Shen , Wang Shuying , Wu Tongwei , Chen Dongjiang , Hu Anjun , Yan Chaoyi , Yan Yichao , Long Jianping , Hu Yin , Lei Tianyu , Li Peng , Chen Wei 
Published: February 2025

AbstractAll solid‐state lithium‐sulfur batteries (ASSLSBs) demonstrate tremendous potential in the next‐generation energy storage system. Nevertheless, the incomplete conversion of Li2S2 to Li2S within the sulfur electrode imposes a substantial impediment on the capacity release. Herein, the nickel single‐atom catalyst (NiNC) materials are employed to ameliorate the sluggish reaction kinetics of polysulfides. Moreover, the unknown origin of the catalytic activity of NiNC materials on the ASSLSBs is revealed by using the ligand‐field theory. The results show that the orbital of Ni exhibits a significant vertical hybridization phenomenon from the inert dsp2 hybridization state to the active d2sp3 hybridization state, which exerts a catalytic effect on the reduction of Li2S2 to Li2S. As a result, the assembled ASSLSBs attain a capacity release of 1506.9 mAh g−1 at 0.05 C and more than 70% retention ratio after 600 cycles at a high rate of 2 C. The in‐depth study of the d‐orbitals of nickel single‐atom catalysts in this work offers deep insights into the relationship between the catalytic substrate and active substance and a novel perspective for the realization of ASSLSB with high energy density.
Reversible adsorption and sieving of trace NH3 from NH3‐H2 fuel cells systems using sulfonated porous polydivinylbenzene
Authors: Qu Yongfang , Zhang Wentao , Zhong Shouchao , Zhuo Linyu , Wang Xi , Fang Huihuang , Lin Changkai , Zheng Yong , Liu Fujian , Jiang Lilong 
Published: February 2025

AbstractTrace ammonia reversible adsorption and sieving using solid adsorbents present a critical challenge in the practical deployment of ammonia‐hydrogen fuel cells. Herein, we design porous polydivinylbenzene (P‐PDVB) through one‐pot solvothermal polymerization without additional templates. Subsequently, solvent‐induced network swelling was performed to achieve deep sulfonation of the P‐PDVB using chlorosulfonic acid, resulting in P‐PDVB‐SO3H‐x, which possess large specific surface areas, abundant micro‐mesoporosity, and high acid site densities. Notably, P‐PDVB‐SO3H‐x demonstrate superior performance for the selective capture and sieving of NH3 from an N2/H2/NH3 mixture, outperforming most previously reported NH3 adsorbents. Thus, P‐PDVB‐SO3H‐x can serve as an efficient adsorbent for the selective removal of trace ammonia from ammonia‐hydrogen fuel cell systems, significantly improving both the efficiency and longevity of the fuel cells. This work highlights the potential of P‐PDVB‐SO3H‐x as a promising candidate for enhancing ammonia‐hydrogen fuel cell performance, paving the way for further exploration of advanced adsorbent materials in energy applications.
Palladium‐Catalyzed Decarboxylative Coupling of Alkynoic Acids with 2‐Alkynylanilines in Ionic Liquid
Authors: Lai Yin‐Long , Xiong Xun , Zhao Ting , Li Jianxiao , Zhong Rui‐Min , Xiong Wenfang , Jiang Huanfeng 
Published: February 2025

AbstractAn efficient and reliable NHC‐palladium‐catalyzed cascade decarboxylative coupling of alkynoic acids with 2‐alkynylanilines for the rapid and straightforward assembly of synthetically valuable 3‐alkynylindole derivatives in eco‐friendly medium is described. Control experiments revealed that NHC−Pd catalysts and base were all essential for this catalytic system. More importantly, this approach features mild reaction conditions, excellent functional group compatibility, and reasonable to excellent yields.
Expert Consensus on Surgical Management of Primary Diffuse Type 2‐Dominant Chronic Rhinosinusitis
Authors: Blauwblomme Manon , Georgalas Christos , Ahmed Shahzada , Alobid Isam , Battaglia Paolo , Castelnuovo Paolo , Constantinidis Jannis , Dallan Iacopo , Eeckels Anne‐Sophie , Ferrari Marco , Gevaert Philippe , Grayson Jessica , Harvey Richard , Herman Philippe , Konstantinidis Iordanis , Lubbe Darlene , Meco Cem , Palmer James , Patel Zara M. , Strzembosz Agnieszka , Verillaud Benjamin , Woodworth Bradford A. , Van Zele Thibaut 
Published: February 2025

ABSTRACTBackgroundChronic rhinosinusitis (CRS) poses significant challenges in surgical management due to the lack of clear guidelines, particularly in type 2 CRS. This review focuses on surgical approaches for primary diffuse type 2‐dominant CRS, emphasizing preoperative and intraoperative strategies.MethodsA consensus group, comprising experts from Europe, United Kingdom, Australia, South Africa, North and South America, was assembled. Using a modified Delphi method, 67 statements were formulated following a literature review, with an additional statement added in the second iteration. Final recommendations were discussed during a consensus meeting in Santorini, Greece, in October 2023.ResultsOut of the 68 proposed statements, consensus was achieved on 45. Most (34) statements received a median score of 7 (strongly agree), and 11 had a median score of 6 (agree). The finalized recommendations cover the indications, timing, extent of surgery, and intraoperative management for both primary and revision surgery in primary diffuse type 2‐dominant CRS. A key focus is on complete sinus surgery, which involves creating a neo‐sinus cavity by removing bone partitions in the ethmoid and opening the frontal and sphenoidal sinuses as needed. Adequate primary and revision surgery includes clearing all nasal polyps and diseased mucosa while ensuring ideal conditions for topical therapy. Additionally, there was consensus on performing complete sinus surgery before considering monoclonal antibody therapies, unless contraindicated.ConclusionThese 45 consensus statements, derived from both current evidence and expert opinion, provide valuable guidance for clinicians in the surgical management of primary diffuse type 2‐dominant CRS.
Travel Costs and Carbon Savings Associated With Telemedicine in a Tertiary Care Rhinology Center
Authors: Kellerman Hunter , Mace Jess C. , Detwiller Kara Y. , Geltzeiler Mathew , Smith Timothy L. , Pandrangi Vivek C. 
Published: February 2025

ABSTRACTObjectiveHealthcare‐associated costs as well as carbon dioxide (CO2) emissions are rising, and identifying means to mitigate these may provide direct benefits to patients as well as overall population health, especially among patients with chronic sinonasal disease. This study aimed to assess potential personal travel costs and CO2 emissions saved due to telemedicine visits.MethodsThis was a retrospective review of patients within Oregon presenting for telemedicine visits at a tertiary rhinology center from July 2022 to July 2023. Distance from patient's address to clinic (miles), as well as estimated average travel time (min), travel costs (USD), and CO2 emissions (kg), were calculated per round trip prevented by providing care at a distance. Area deprivation indices (ADI) were obtained based on nine‐digit zip codes.ResultsAmong 354 included visits, the mean ± standard deviation (SD) age was 57.03 ± 16.58 years. Chronic rhinosinusitis (CRS) was the most common diagnosis (55.4%). The majority of visits were follow‐up (65.5%) or preoperative (26.8%). Approximately 64,977.00 miles and 66,988.67 min (∼1,116 h) of roundtrip travel were saved, reducing CO2 emissions by 26,705.55 kg (equivalent to 3,005 gallons of gasoline consumed or 5.6 homes’ electricity use for 1 year). Patients within the highest ADI quartile (Q), indicating highest socioeconomic disadvantage, had the highest travel costs saved (median [interquartile range]; Q1, $12.24 [$18.36]; Q2, $134.33 [$274.38]; Q3, $256.69 [$191.52]; Q4, $364.42 [$154.28]; p < 0.001).ConclusionsTelemedicine may facilitate reduction in the carbon footprint associated with healthcare as well as reduce indirect healthcare costs associated with travel.
A new experimental model for studying peripheral nerve regeneration in dual innervated facial reanimation
Authors: Bayezid K. Can , Macek Jan , Kubíčková Lucie , Bretová Karolína , Joukal Marek , Streit Libor 
Published: February 2025

AbstractBackgroundDonor nerve selection is a crucial factor in determining clinical outcomes of facial reanimation. Although dual innervation approaches using two neurotizers have shown promise, there is a lack of evidence‐based comparison in the literature. Furthermore, no animal model of dual reinnervation has yet been published. This study aimed to establish such a model and verify its technical and anatomical feasibility by performing dual‐innervated reanimation approaches in Wistar rats.MethodsFifteen Wistar rats were divided into four experimental groups and one control group. The sural nerve was exposed and used as a cross‐face nerve graft (CFNG), which was then anastomosed to the contralateral buccal branch of the facial nerve through a subcutaneous tunnel on the forehead. The CFNG, the masseteric nerve (MN), and the recipient nerve were coapted in one or two stages. The length and width of the utilized structures were measured under an operating microscope. Return of whisker motion was visually confirmed.ResultsNine out of the eleven rats that underwent surgery survived the procedure. Whisker motion was observed in all experimental animals, indicating successful reinnervation. The mean duration of the surgical procedures did not differ significantly between the experimental groups, ensuring similar conditions for all groups.ConclusionsOur experimental study confirmed that the proposed reanimation model in Wistar rats is anatomically and technically feasible, with a high success rate, and shows good prospects for future experiments.
Structural Regulation of Three‐Dimensional Covalent Organic Frameworks for Efficient Photoredox Catalysis toward Atom Transfer Radical Polymerization
Authors: Niu Sheng , Hu Zhenyang , Xu Xiaoyi , Xiong Zuping , Chen Hongzheng , Jen Alex K.‐Y. , Huang Ning 
Published: February 2025

AbstractCovalent organic frameworks (COFs) have emerged as a thriving class of photocatalysts in various chemical transformations. However, the utilization of COFs as photoredox catalysts for atom transfer radical polymerization is rarely known. Herein, we designed and synthesized a series of phenazine‐based functional 3D COFs with the dia topology. Structural regulation over interpenetration folds and energy levels of COFs was implemented through the substituent effects. These COFs can work as effective photoredox catalysts toward atom transfer radical polymerization. Notably, DADP‐CF3‐COF with trifluoromethyl group exhibits much higher catalytic activity than other COFs, allowing the efficient synthesis of polymers with controllable molecular weights, low dispersity, and high conversion. This work not merely realizes the structural regulation of 3D COFs through substituent effects, but also exhibits brilliant prospects for the utilization of COFs as efficient catalysts in a bunch of challenging chemical transformations.
Sulfur Conversion to Donor‐Acceptor Ladder Polymer Networks through Mechanochemical Nucleophilic Aromatic Substitution for Efficient CO2 Photoreduction
Authors: Yang Na , Zhou Zi‐Jian , Zhu Xiang , Wu Jiwei , Zhang Yifan , Wang Tao , Wu Xin‐Ping , Tian Chengcheng , Jiang Xia , Dai Sheng 
Published: February 2025

AbstractThe development of synthetic methods capable of converting elemental sulfur into conjugated porous sulfur‐rich polymers remains a great challenge, although direct utilization of this readily available feedstock can significantly enrich its uses and circumvent environmental problems during sulfur storage. We report herein mechanochemical (MC) nucleophilic aromatic substitution (SNAr) that enables sulfur conversion into thianthrene‐bridged porous ladder polymer networks with dense donor‐acceptor (D−A) molecular junctions. We demonstrate that the key lies in the generation of bent thianthrene units through a solid‐state ball‐milling condensation reaction between 1,2‐dihaloarenes and elemental sulfur. We also show that the assembling of D−A structural motifs into porous networks affords efficient visible‐light‐driven photocatalytic reduction of carbon dioxide (CO2) with water (H2O) vapor, in the absence of any additional photosensitizer, sacrificial agents or cocatalysts. Exceptional photoinduced charge separation along with boosted exciton dissociation results in a high‐performance of carbon monoxide (CO) production rate of 306.1 μmol g−1 h−1 with near 100 % CO selectivity, which is accompanied by H2O oxidation to O2, as confirmed by both experimental and theoretical results. We anticipate this novel MC SNAr approach will advance processing techniques for direct sulfur utilization and facilitate new possibilities for the synthesis of D−A ladder polymer networks with promising potential in photocatalysis.
A Novel Z‐Scheme Ag3PO4/SrTiO3 Heterojunction for Highly Efficient Photocatalytic Degradation
Authors: Zheng Yanzhi , Sun Yu , Yang Zihan , Liu Yuqing , Sun Xiaotong , Li Lixia , Cao Wanning , Yang Jingkai 
Published: February 2025

ABSTRACTThere are still challenges to eliminate and reduce the harmful persistent organic pollutants (POPs) in the water, especially the dye‐based POPs. Two big obstacles the Ag3PO4 photocatalyst faces are serious carrier recombination and photocorrosion, which presents a limitation for its application in water purification. Therefore, in this work, a novel Ag3PO4/SrTiO3 heterojunction was synthesized by a simple in situ deposition method. Ag3PO4/SrTiO3 10:1 exhibits the highest photocatalytic activity with rhodamine B (RhB) degradation of 98.8% in only 20 min and methyl orange (MO) degradation of 97.5% in 80 min under simulated sunlight irradiation, which is much higher than that of pure Ag3PO4 and the mixed photocatalysts. During the photocatalytic reaction, h+ and •O2− are the main active species, and the charge transfer path is satisfied with the Z‐scheme mechanism. Additionally, the possible degradation pathways of RhB and MO were proposed by analyzing the intermediate products via HPLC‐MS.
Rapid Synthesis of Molybdenum Disulfide@Ferric Oxide Nanomaterials Using Gamma Rays for the Efficient Improvement of the Flame Retardancy and Mechanical Properties of EVA/Magnesium Hydroxide Composites
Authors: Qin Huijie , Zhang Tongwei , Bao Lihong , Dang Bo , Li Jianxi 
Published: February 2025

ABSTRACTIn this research, iron tetroxide (Fe₃O₄) nanoparticles were in situ synthesized on the surface of molybdenum disulfide (MoS2) via a radiation technique to fabricate a MoS₂@Fe₃O₄ hybrid. Notably, the tensile strength and elongation at break of ethylene vinyl acetate (EVA)/magnesium hydroxide (MH) composites were enhanced by 62.5% and 59.1%, respectively, with the addition of one part of the MoS₂@Fe₃O₄ hybrid, attributed to its excellent reinforcing effect. Simultaneously, the peak heat release rate (pHRR) and total heat release of the EVA/MH composite decreased by 45.9% and 14.4%, respectively, while the residue content increased to 43.4%. Furthermore, EVA/MH/MoS₂@Fe₃O₄ composites with one part of the MoS₂@Fe₃O₄ hybrid generated significantly fewer toxic gases (such as CO) compared to EVA/MH composites, demonstrating enhanced fire safety. This study underscores the potential of creating noble metal‐free layered composites by integrating cost‐effective and eco‐friendly Fe₃O₄ co‐catalysts, such as MoS₂@Fe₃O₄ hybrids, to improve the fire safety of EVA composites.