bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structural insights into physiological activation and antagonism of melanin-concentrating hormone receptor MCHR1
Authors: Ye Xiaofan , Liu Guibing , Li Xiu , He Binbin , Tao Yuyong , Liu Haiping , Gong Weimin 
Published: March 2024

AbstractMelanin-concentrating hormone (MCH) is a 19-amino-acid neuropeptide playing crucial roles in energy homeostasis, sleep, and various physiological processes. It acts through two G protein-coupled receptors, MCHR1 and MCHR2, with MCHR1 being universally present in mammals and a potential target for treating metabolic and mental health conditions. However, drug development efforts have been impeded by the lack of structural information. Here, we present the cryo-EM structures of MCHR1 in its active state complexed with MCH and Gi1, as well as in its inactive state bound to a selective antagonist SNAP-94847. Structural and mutagenesis analyses disclosed the recognition mechanisms for both MCH and SNAP-94847, the activation mechanism and antagonism of MCHR1, and the determinants of ligand specificity. These findings are expected to accelerate the development of better drugs targeting the MCH system.
Metabolism of FAD, FMN and riboflavin (vitamin B2) in the human parasitic blood flukeSchistosoma mansoni
Authors: Da’dara Akram A. , Nation Catherine S. , Skelly Patrick J. 
Published: March 2024

SummarySchistosomiasis is a parasitic disease caused by trematode worms of the genusSchistosoma.The intravascular worms acquire the nutrients necessary for their survival from host blood. Since all animals are auxotrophic for riboflavin (vitamin B2), schistosomes too must import it to survive. Riboflavin is an essential component of the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD); these support key functions of dozens of flavoenzymes. In this work we focus on the biochemistry of riboflavin and its metabolites inSchistosoma mansoni. We show that when schistosomes are incubated in murine plasma, levels of FAD decrease over time while the levels of FMN increase. We show that live schistosomes can cleave exogenous FAD to generate FMN and this ability is significantly blocked when expression of the surface ectoenzyme SmNPP5 is suppressed using RNAi. Recombinant SmNPP5 cleaves FAD with a Km of 178 ± 5.9 µM. The FAD-dependent enzyme IL-4I1 drives the oxidative deamination of phenylalanine to produce phenylpyruvate and H2O2in the extracellular environment. Since schistosomes can be damaged by H2O2, we determined if SmNPP5 could impede H2O2production by blocking IL-4I1 actionin vitro. We found that this was not the case, suggesting that covalently bound FAD on IL-4I1 is inaccessible to SmNPP5. We also report here that live schistosomes can cleave exogenous FMN to generate riboflavin and this ability is significantly impeded when expression of a second surface ectoenzyme (alkaline phosphatase, SmAP) is suppressed. Recombinant SmAP cleaves FMN with a Km of 3.82 ± 0.58 mM. Thus, the sequential hydrolysis of FAD by tegumental ecto-enzymes SmNPP5 and SmAP can generate free vitamin B2 around the worms from where it can be conveniently imported by, we hypothesize, the recently described schistosome riboflavin transporter SmaRT. In this work we also identifiedin silicoschistosome homologs of enzymes that are involved in intracellular vitamin B2 metabolism. These are riboflavin kinase (SmRFK) as well as FAD synthase (SmFADS); cDNAs encoding these two enzymes were cloned and sequenced. SmRFK is predicted to convert riboflavin to FMN while SmFADS could further act on FMN to regenerate FAD in order to facilitate robust vitamin B2-dependent metabolism in schistosomes.
Energy dependence of
J/ψ
production in
pp
collisions from the PACIAE model
Authors: Ye Kai-Fan , Wang Qiang , Shi Jia-Hao , Qin Zhi-Ying , Zhang Wen-Chao , Lei An-Ke , She Zhi-Lei , Yan Yu-Liang , Sa Ben-Hao 
Published: March 2024

In this work we investigate the J/ψ production in proton-proton collisions at the center-of-mass energy (s) equal to 2.76, 5.02, 7, 8, and 13 TeV with the parton and hadron cascade model PACIAE 2.2a. It is based on PYTHIA but extended considering the partonic and hadronic rescatterings before and after hadronization, respectively. In the PYTHIA sector the J/ψ production quantum chromodynamics processes are selected specially and a bias factor is proposed correspondingly. The calculated total cross sections, the transverse momentum differential, and the rapidity differential cross sections of J/ψ in the forward rapidity region reproduce the corresponding experimental measurements reasonably well. In the mid-rapidity region, the double-differential cross sections at s=5.02, 7, and 13 TeV are also in a good agreement with the experimental data. Moreover, we interpolate the double-differential cross section as well as the total cross section of J/ψ in the mid-rapidity region at s=8 TeV, which could be validated if the experimental data are available.

Published by the American Physical Society
2024
Complementary LHC searches for UV resonances of the
0νββ
decay operators
Authors: Li Gang , Yu Jiang-Hao , Zhao Xiang 
Published: March 2024

We investigate the quark-level effective operators related to the neutrinoless double beta (0νββ) decay process and their ultraviolet completions relevant to chiral enhancement effects at the hadronic level. We have classified several kinds of leptoquark models, matching to different standard model effective operators. Assuming weakly coupled new physics, we find the ongoing 0νββ decay experiments are sensitive to new physics scale at around 2–4 TeV, which is in the reach of LHC searches. We discuss the discovery potential of such resonances in the same-sign dilepton channels at the LHC. Therefore, the direct LHC searches and indirect 0νββ decay searches are complementary to each other in testing the UV completions of the effective operators for 0νββ decay.

Published by the American Physical Society
2024
Inhomogeneous condensation in the Gross-Neveu model in noninteger spatial dimensions
1≤d<3
. II. Nonzero temperature and chemical potential
Authors: Koenigstein Adrian , Pannullo Laurin 
Published: March 2024

We continue previous investigations of the (inhomogeneous) phase structure of the Gross-Neveu model in a noninteger number of spatial dimensions (1≤d<3) in the limit of an infinite number of fermion species (N→∞) at (non)zero chemical potential μ [L. Pannullo, Inhomogeneous condensation in the Gross-Neveu model in noninteger spatial dimensions 1≤d<3, ]. In this work, we extend the analysis from zero to nonzero temperature T. The phase diagram of the Gross-Neveu model in 1≤d<3 spatial dimensions is well-known under the assumption of spatially homogeneous condensation with both a symmetry broken and a symmetric phase present for all spatial dimensions. In d=1 one additionally finds an inhomogeneous phase, where the order parameter, the condensate, is varying in space. Similarly, phases of spatially varying condensates are also found in the Gross-Neveu model in d=2 and d=3, as long as the theory is not fully renormalized, i.e., in the presence of a regulator. For d=2, one observes that the inhomogeneous phase vanishes, when the regulator is properly removed (which is not possible for d=3 without introducing additional parameters). In the present work, we use the stability analysis of the symmetric phase to study the presence (for 1≤d<2) and absence (for 2≤d<3) of these inhomogeneous phases and the related moat regimes in the fully renormalized Gross-Neveu model in the μ, T-plane. We also discuss the relation between “the number of spatial dimensions” and “studying the model with a finite regulator” as well as the possible consequences for the limit d→3.

Published by the American Physical Society
2024
Electrostatic Trapping of
N2
Molecules in High Rydberg States
Authors: Rayment M. H. , Hogan S. D. 
Published: March 2024

N2 molecules traveling in pulsed supersonic beams have been excited from their X Σg+1 ground electronic state to long-lived Rydberg states with principal quantum numbers between 39 and 48 using a resonance-enhanced two-color three-photon excitation scheme. The Rydberg states populated had static electric dipole moments exceeding 5000 D which allowed deceleration of the molecules to rest in the laboratory-fixed frame of reference and three-dimensional trapping using inhomogeneous electric fields. The trapped molecules were confined for up to 10 ms, with effective trap decay time constants increasing with principal quantum number, and ranging from 450 to 700  μs. These observations, and comparison with the results of similar measurements with He atoms, indicate that the decay dynamics of the trapped Rydberg N2 molecules are dominated by spontaneous emission and do not exhibit significant contributions from effects of intramolecular interactions that lead to non-radiative decay.

Published by the American Physical Society
2024
Does culture moderate the innovation input–output relationship? A two-stage configurational analysis
Authors: Duarte Marcelo Pereira , Carvalho Fernando Manuel P.O. 
Published: March 2024

PurposeThis study analyses configurations of national culture as boundary conditions of countries’ national systems of innovation (NSI). Drawing from the NSI approach, we argue that culture’s role is that of a contingency factor shaping the relationship between investments in innovation and national innovation outputs.Design/methodology/approachWe assessed the moderation effect of national culture through a systematic, two-stage approach using fuzzy-set Qualitative Comparative Analysis (fsQCA), which allows the analysis of changes induced by the moderator variables. Analyses were conducted with a diverse sample of 61 countries over a period spanning 12 years, from 2011 to 2022.FindingsFindings reveal that investments in innovation, but not individual cultural dimensions, is a necessary condition for high innovation outputs. Furthermore, several configurations of cultural dimensions were identified as moderators of the relationship between investments in innovation and innovation outputs.Originality/valueThis study provides insights into cross-national innovation research by exposing the role of cultural configurations, rather than just individual cultural dimensions, as boundary conditions involved in the achievement of high levels of innovation.
Uniform diffracted fields of the extended theory of BDW from the circular aperture on a perfectly magnetic conductive surface
Authors: Altınel Mustafa , Yalçın Uğur 
Published: March 2024

Purpose
This paper aims to examine the uniform diffracted fields from a perfectly magnetic conductive (PMC) surface with the extended theory of boundary diffraction wave (BDW) approach.

Design/methodology/approach
Miyamoto and Wolf’s symbolic expression of the vector potential was used in the extended theory of BDW integral. This vector potential is applied to the problem, and the nonuniform field expression found was made uniform. Here, the expression is made uniform, using the detour parameter with the help of the asymptotic correlation of the Fresnel function. The BDW theory for the PMC surface extended the diffracted fields, and the uniform diffracted fields were calculated.

Findings
The field expressions obtained were interpreted with the graphs numerically for different aperture radii and observation distances. It has been shown that the BDW is continuous behind the diffracting aperture. There does not exist any discontinuity at the geometrically light-to-shadow transition boundary, as is required by the theory.

Originality/value
The results were graphically compared with diffracted fields for other surfaces. As far as we know, the uniform diffracted fields from the circular aperture on a PMC surface were calculated for the first time with the extended theory of the BDW approach.
Multichannel relational communication strategy: does one-sized strategy fit all customers?
Authors: Ramos Carla , Bruscato Bortoluzzo Adriana , Claro Danny P. 
Published: March 2024

Purpose
This study aims to capture how the association between a multichannel relational communication strategy (MRCS) and customer performance is contingent upon such customer performance (low- versus high-performance customers) and to reconcile past contradictory results in this marketing-related topic. To this end, the authors propose and validate the method of quantile regression as an unconventional, yet effective, means to proceed to that reconciliation.

Design/methodology/approach
This study collected data from 4,934 customers of a private pension fund firm and accounted for both firm- and customer-initiated relational communication channels (RCCs) and for customer lifetime value (CLV). This study estimated a generalized linear model and then a quantile regression model was used to account for customer performance heterogeneity.

Findings
This study finds that specific RCCs present different levels of association with performance for low- versus high-performance customers, where outcome customer performance is the dependent variable. For example, the relation between firm-initiated communication (FIC) and performance is stronger for low-CLV customers, whereas the relation between customer-initiated communication (CIC) and performance is increasingly stronger for high-CLV customers but not for low-CLV ones. This study also finds that combining different forms of FIC can result in a negative association with customer performance, especially for low-CLV customers.

Research limitations/implications
The authors tested the conceptual model in one single firm in the specific context of financial services and with cross-sectional data, so there should be caution when extrapolating this study’s findings.

Practical implications
This study offers nuanced and precise managerial insights on recommended resource allocation along with relational communication efforts, showing how managers can benefit from adopting a differentiated-customer performance approach when designing their MRCS.

Originality/value
This study provides an overview of the state of the art of MRCS, proposes a contingency analysis of the relationship between MRCS and performance based on customer performance heterogeneity and suggests the quantile method to perform such analysis and help reconcile past contradictory findings. This study shows how the association between RCCs and CLV varies across the conditional quantiles of the distribution of customer performance. This study also addresses a recent call for a more holistic perspective on the relationships between independent and dependent variables.
Built environment professionals’ perspective on digital technology skills
Authors: Balogun Teslim Bamidele 
Published: March 2024

PurposeThis study aims to explore the opinions of Built Environment Professionals (BEP) on the usage of fourth-generation digital technologies in the construction industry.Design/methodology/approachThis study adopts a qualitative research approach and conducts semi-structured interviews with Black, Asian and Minority Ethnic (BAME) professionals to explore the adoption and utilisation of fourth-generation digital technologies in the construction industry. The semi-structured interviews allowed the participants to elaborate on their experiences, and thematic analysis was employed to identify and analyse significant themes related to the topic.FindingsAccounts from BAME construction professionals reveal that the increased popularity of fourth-generation digital technologies, also known as Industry 4.0 technologies, does not necessarily result in increased usage. This is because many of these new technologies have not been embraced and are unpopular in certain circles. A more significant revelation is the impact of BAME community settings on determining the career pathways of most individuals, which often do not support the construction or digital technology pathways within the construction industry.Research limitations/implicationsResearch targeting ethnic minorities may not necessarily yield a large response due to the sensitivity of the issues raised. However, conducting a nationwide research with a larger sample size drawn from various locations in the UK could achieve more robust findings and uncover additional issues. Meanwhile, the results of this research can serve as a framework for more extensive investigations.Practical implicationsThe research offers valuable recommendations to industry and academia regarding the need to address the specific challenges faced by the BAME community in terms of digital technology adoption. These issues are often overlooked in most discussions about digital technology.Originality/valueThe study provides critical recommendations that are relevant to Further and Higher Education (HE) institutions, industries, construction organisations, government bodies, etc. Recommendations include a call for collaboration between educational institutions, industry partners and local communities to facilitate awareness and orientation programmes within the community.
Does bankruptcy law affect the relation between leverage and firm performance?
Authors: Rastogi Nikhil , Kumar Satish 
Published: March 2024

Purpose
The purpose of this paper is to examine the impact of bankruptcy reform in the year 2016 on the relation between leverage and firm performance for Indian firms, separately for business group and standalone firms.

Design/methodology/approach
Fixed effects panel regression is used to understand the role of bankruptcy reform on firm-level data to examine the relationship between leverage and firm performance after controlling for size, growth, age, liquidity and promoter shareholding. The authors also apply the generalized method of moments (GMM) to control for the endogeneity concerns.

Findings
The authors show that the introduction of the insolvency and bankruptcy code (IBC) positively moderates the relation between leverage and firm performance such that the extent of negative relation between leverage and firm performance is less in the post-IBC period. The positive impact of IBC on the relation between leverage and firm performance holds only for firms not affiliated to business groups and for firms with higher debt in their capital structure.

Practical implications
The study’s findings will help the regulators appreciate the effectiveness of bankruptcy reforms resulting from IBC implementation in terms of sound bankruptcy process and leading to safeguard the interests of minority shareholders.

Originality/value
The authors provide the only study to examine the role of bankruptcy law in moderating the relation between leverage and firm performance across a sample of business group and standalone firms.
Cross ownership and merger under technology adoption
Authors: Mukherjee Arijit 
Published: March 2024

Purpose
This paper aims to consider the effects of a merger on technology adoption and welfare in the presence of passive cross ownership. Merger increases investments in process technology and may increase welfare. The results are important for antitrust policies and suggest that the antitrust authorities may not need to be too concerned about mergers in industries with cross ownership.

Design/methodology/approach
Game-theoretic analysis.

Findings
Merger increases investments in process technology and may increase welfare.

Originality/value
To the best of the author’s knowledge, this study is original.
Perceptions of religious Israeli high school principals regarding school climate after the COVID-19 pandemic, and its connection to their management style
Authors: Ben Harush Eli 
Published: March 2024

PurposeThe global COVID-19 crisis posed many managerial and leadership challenges for principals. More specifically, after the crisis passed noticeable changes in school climate manifested and affected principal management style. The present study examined perceptions of principals regarding school climate and its impact on management style. The research literature clearly affirms the profound impact of school climate in terms of the relationship between students and school leaders. The study focused solely on religious high schools because, in Israel, the negative impact of the pandemic was most marked there.Design/methodology/approachThe study was qualitative in nature, and included semi-structured interviews with 10 religious school principals in Israel. Study participants were asked about the existing school climate and their management style in light of the COVID-19 period.FindingsThis study indicated that positive school climate and interpersonal relationships between principals and students were affected by the COVID-19 crisis. Study participants reported that principals had to work arduously in the post-COVID-19 period to restore and improve positive school climate and consequently their management style also needed altering. Specifically, restoring open lines of communication and a sense of belonging as the main components of the school climate were the main foci of principal work. The principals' management style had to be more open and inclusive to restore a sense of belonging and security among students.Originality/valueThe study highlights the importance of an open and inclusive management style to restore positive school climate after crises.
Quantifying BIM investment value: a systematic review
Authors: Gharaibeh Lina , Eriksson Kristina , Lantz Björn 
Published: March 2024

Purpose
Perceived benefits of building information modelling (BIM) have been discussed for some time, but cost–benefit benchmarking has been inconsistent. The purpose of this paper is to investigate BIM feasibility and evaluate investment worth to elucidate and develop the current understanding of BIM merit. The aim of the study is to propose a research agenda towards a more holistic perspective of BIM use incorporating quantifying investment return.

Design/methodology/approach
An in-depth examination of research patterns has been conducted to identify challenges in the assessment of the investment value and return on investment (ROI) for BIM in the construction industry. A total of 75 research articles were considered for the final literature review. An evaluation of the literature is conducted using a combination of bibliometric analysis and systematic reviews.

Findings
This study, which analysed 75 articles, unveils key findings in quantifying BIM benefits, primarily through ROI calculation. Two major research gaps are identified: the absence of a standardized BIM ROI method and insufficient exploration of intangible benefits. Research focus varies across phases, emphasizing design and construction integration and exploring post-construction phases. The study categorizes quantifiable factors, including productivity, changes and rework reduction, requests for information reduction, schedule efficiency, safety, environmental sustainability and operations and facility management. These findings offer vital insights for researchers and practitioners, enhancing understanding of ’BIM’s financial benefits and signalling areas for further exploration in construction.

Originality/value
The ’study’s outcomes offer the latest insights for researchers and practitioners to create effective approaches for quantifying ’BIM’s financial benefits. Additionally, the proposed research agenda aims to improve the current limited understanding of BIM feasibility and investment worth evaluation. Results of the study could assist practitioners in overcoming limitations associated with BIM investment and economic evaluations in the construction industry.