bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis and Pharmacological Investigation of Novel 1‐Alkyl‐4‐(4‐substituted aryl/heteroaryl)‐1,2,4‐triazolo[4,3‐a]quinazolin‐5(4H)‐ones as a New Class of H1‐Antihistaminic Agents.
Authors: Alagarsamy Veerachamy , Yadav Mangae Ram , Giridhar Rajani 
Published: March 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
An Efficient Route to Thieno[2,3‐d]pyrimidine Derivatives by Tandem [2,3] and [3,3] Sigmatropic Rearrangement.
Authors: Majumdar Krishna C. , Pal Nilasish , Chattopadhyay Sudip K. 
Published: March 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of Tricyclic Pyrazolo[1,5‐a]pyrimidin‐7(4H)‐ones Featuring Regioselective Formation of the Core Structure.
Authors: Parchinsky Vladislav Z. , Ushakova Olga , Kravchenko Dmitry V. , Krasavin Mikhail 
Published: March 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
An Expeditious Synthesis of 1,5‐Benzodiazepine Derivatives Catalyzed by CdCl2.
Authors: Pasha M. A. , Jayashankara V. P. 
Published: March 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
An Enantio‐ and Diastereoselective Synthesis of Fluorinated β‐Aminoalkyloxepin Derivatives Through Mannich and Ring‐Closing Metathesis Reactions.
Authors: Fustero Santos , Esteban Elisabet , Sanz‐Cervera Juan F. , Jimenez Diego , Mojarrad Fatemeh 
Published: March 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Novaxenicins A—D and Xeniolides I—K, Seven New Diterpenes from the Soft Coral Xenia novaebrittaniae.
Authors: Bishara Ashgan , Rudi Amira , Goldberg Israel , Benayahu Yehuda , Kashman Yoel 
Published: March 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Potential Antiallergic ent‐Kaurene Diterpenes from the Bark of Suregada multiflora.
Authors: Cheenpracha Sarot , Yodsaoue Orapun , Karalai Chatchanok , Ponglimanont Chanita , Subhadhirasakul Sanan , Tewtrakul Supinya , Kanjana‐opas Akkharawit 
Published: March 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Alder‐Ene Reaction of 3‐Methyl‐3‐cyanocyclopropene with Monoterpenes.
Authors: Ashirov Roman V. , Balandina Alsu A. , Kharlamov Sergey V. , Appolonova Svetlana A. , Figadere Bruno , Latypov Shamil K. , Plemenkov Vitali V. 
Published: March 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Enantioselective Synthesis of Non‐Proteinogenic 2‐Arylallyl‐α‐amino Acids via Pd/In Catalytic Cascades.
Authors: Grigg Ronald , McCaffrey Shaun , Sridharan Visuvanathar , Fishwick Colin W. G. , Kilner Colin , Korn Stewart , Bailey Kevin , Blacker John 
Published: March 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Janthinolide A and B, Two New 2,5‐Piperazinedione Derivatives from the Endophytic Penicillium janthinellum Isolated from the Soft Coral Dendronephthya sp.
Authors: Xue Chunmei , Li Tian , Deng Zhiwei , Fu Hongzheng , Lin Wenhan 
Published: March 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Cruentaren, a New Antifungal Salicylate‐Type Macrolide from Byssovorax cruenta (Myxobacteria) with Inhibitory Effect on Mitochondrial ATPase Activity. Fermentation and Biological Properties. Part 104. Antibiotics from Gliding Bacteria.
Authors: Kunze Brigitte , Steinmetz Heinrich , Hoefle Gerhard , Huss Markus , Wieczorek Helmut , Reichenbach Hans 
Published: March 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Enzyme‐Assisted Introduction and Cleavage of Protecting Groups in Nucleoside Chemistry
Authors: Santaniello Enzo , Alessandrini Laura , Ciuffreda Pierangela 
Published: March 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Area map of mouse visual cortex
Authors: Wang Quanxin , Burkhalter Andreas 
Published: March 2007

AbstractIt is controversial whether mouse extrastriate cortex has a “simple” organization in which lateral primary visual cortex (V1) is adjoined by a single area V2 or has a “complex” organization, in which lateral V1 is adjoined by multiple distinct areas, all of which share the vertical meridian with V1. Resolving this issue is important for understanding the evolution and development of cortical arealization. We have used triple pathway tracing combined with receptive field recordings to map azimuth and elevation in the same brain and have referenced these maps against callosal landmarks. We found that V1 projects to 15 cortical fields. At least nine of these contain maps with complete and orderly representations of the entire visual hemifield and therefore represent distinct areas. One of these, PM, adjoins V1 at the medial border. Five areas, P, LM, AL, RL, and A, adjoin V1 on the lateral border, but only LM shares the vertical meridian representation with V1. This suggests that LM is homologous to V2 and that the lateral extrastriate areas do not represent modules within a single area V2. Thus, mouse visual cortex is “simple” in the sense that lateral V1 is adjoined by a single V2‐like area, LM, and “complex” in having a string of areas in lateral extrastriate cortex, which receive direct V1 input. The results suggest that large numbers of areas with topologically equivalent maps of the visual field emerge early in evolution and that homologous areas are inherited in different mammalian lineages. J. Comp. Neurol. 502:339–357, 2007. © 2007 Wiley‐Liss, Inc.
Early exposure to methylphenidate increases fear responses in an aversive context in adult rats
Authors: Britton Gabrielle B. , Segan Andrew T. , Sejour Jeffrey , Mancebo Silvia E. 
Published: March 2007

AbstractThe effects of methylphenidate hydrochloride (MPH) administration during development on fear acquisition and retention in adulthood were examined using classical fear conditioning. Male Sprague–Dawley rats were administered MPH (2 mg/kg) or saline twice daily from postnatal day (PD) 25 to 39, and were trained and tested on PD 81 and 82. During training, shock unconditioned stimulus (US) presentations were explicitly paired with an auditory conditioned stimulus (CS) or occurred unsignaled in the training context. No effect of MPH treatment was found during fear acquisition when shock was signaled or unsignaled during training, but 24 h retention tests in the training context revealed enhanced fear responses in MPH‐treated animals that received unsignaled training. These results support recent reports of enhanced anxiety‐like behaviors in adult rats caused by early developmental MPH treatment and highlight the need for further research into the long‐term effects of developmental exposure to stimulants aimed at pediatric populations. © 2007 Wiley Periodicals, Inc. Dev Psychobiol 49: 265–275, 2007.
Gain of affinity point mutation in the serotonin receptor gene 5‐HT2Dro accelerates germband extension movements during Drosophila gastrulation
Authors: Schaerlinger B. , Launay J.M. , Vonesch J.l. , Maroteaux L. 
Published: March 2007

AbstractSerotonin (5‐HT) not only works as a neurotransmitter in the nervous system, but also as a morphogenetic factor during early embryogenesis. In Drosophila, a previous report showed that embryos that lack the 5‐HT2Dro receptor locus, display abnormal gastrulation movements. In this work, we screened for point mutations in the 5‐HT2Dro receptor gene. We identified one point mutation that generates a gain of serotonin affinity for the receptor and affects germband extension: 5‐HT2DroC1644. Embryos homozygous for this point mutation display a fourfold increase in the maximal speed of ectodermal cell movements during the rapid phase of germband extension. Homozygous 5‐HT2DroC1644 embryos present a cuticular phenotype, including a total lack of denticle belt. Identification of this gain of function mutation shows the participation of serotonin in the regulation of the cell speed movements during the germband extension and suggests a role of serotonin in the regulation of cuticular formation during early embryogenesis. Developmental Dynamics 236:991–999, 2007. © 2007 Wiley‐Liss, Inc.
Simultaneous identification of natural dyes in the collection of drawings and maps from The Royal Chancellery Archives in Granada (Spain) by CE
Authors: López‐Montes Ana , Blanc García Rosario , Espejo Teresa , Huertas‐Perez José F. , Navalón Alberto , Vílchez José Luis 
Published: March 2007

AbstractA simple and rapid capillary electrophoretic method with UV detection (CE–UV) has been developed for the identification of five natural dyes namely, carmine, indigo, saffron, gamboge and Rubia tinctoria root. The separation was performed in a fused‐silica capillary of 64.5 cm length and 50 μm id. The running buffer was 40 mM sodium tetraborate buffer solution (pH 9.25). The applied potential was 30 kV, the temperature was 25°C and detections were performed at 196, 232, 252, 300 and 356 nm. The injections were under pressure of 50 mbar during 13 s. The method was applied to the identification of carminic acid, gambogic acid, crocetin, indigotin, alizarin and purpurin in the collection of drawings and maps at the Royal Chancellery Archives in Granada (Spain). The method was validated by using HPLC as a reference method.
Does perinatal antiretroviral therapy create an iatrogenic cancer risk?
Authors: Wogan Gerald N. 
Published: March 2007

AbstractAntiretroviral therapy is highly effective in reducing vertical transfer of HIV infection, sparing many thousands of children premature death from AIDS. However, accumulating evidence indicates that perinatal exposure to antiretroviral agents may place them at elevated risk of developing cancer later in life, owing to potential carcinogenic effects of the agents. An initial experimental evaluation clearly demonstrated that AZT was a genotoxin and transplacental carcinogen of intermediate potency in CD‐1 mice. This issue of Environmental and Molecular Mutagenesis contains reports of recent studies designed to confirm and extend earlier findings, and to provide further perspective that will facilitate development of strategies through which the adverse effects might be mitigated. The studies focused on various aspects of the genotoxicity and carcinogenicity of antiretroviral agents, including: mutagenesis in several in vitro experimental systems; mutations and clastogenic effects induced by transplacental administration in mice; transplacental carcinogenesis and mutations in oncogenes and tumor suppressor genes in tumors of mice; and genotoxicity and clastogenicity following perinatal exposure of HIV‐infected mothers and their uninfected infants. Collectively, the results obtained provide convincing biological plausibility for the postulate that perinatal exposure to nucleoside analogs puts children at elevated risk of developing cancers later in life. They further emphasize the importance of continued surveillance of these children for increased cancer risk and indicate a need for efforts to develop less genotoxic alternative agents. Environ. Mol. Mutagen., 2007. © 2007 Wiley‐Liss, Inc.
Vibration of cylindrical shells with clamped ends
Authors: Warburton G. B. , Higgs J. 
Published: March 2007

AbstractA general method is outlined for the determination of natural frequencies of cylindrical shells with any boundary conditions when the effects of rotatory inertia and transverse shear deformation are included in the analysis. This is applied to cylindrical shells with both ends clamped. It is shown that the inclusion of these effects tends to have a greater effect upon frequencies of cylindrical shells with clamped ends than it does for corresponding shells with simply supported ends, for which numerical results are available. The authors suggest an empirical relation, which together with the latter results enables rapid estimates to be made of the effects of rotatory inertia and shear deformation on the frequencies of a wide range of cylindrical shells with clamped ends. An assessment of the accuracy of the theory with these effects included is made by comparing frequencies with values from a three‐dimensional elasticity theory, but this comparison has to be restricted to cylindrical shells with simply supported ends.
On increasing the structural damping of a steel chimney
Authors: Johns D. J. , Britton J. , Stoppard G. 
Published: March 2007

AbstractExperimental results of a study which was commissioned to investigate the possible benefit of added structural damping in reducing the susceptibility of a steel chimney to wind‐excited swaying vibrations are presented and discussed. The experimental and analytical techniques used are briefly described.The results indicated a significant increase in structural damping when pads of a special damping material were incorporated into the foundation structure of the chimney.
The dynamic response of gravity platforms
Authors: Dungar R. , Eldred P. J. L. 
Published: March 2007

AbstractGravity platforms, together with associated regions of foundation and fluid, are idealized using the finite element method. Radiation of wave energy away from the platform region is modelled by appropriate damping applied to the boundary of the foundation mesh. Response results, due to sinusoidally applied forces, are calculated for seven platform‐foundation configurations. Of particular interest are those results for various assumed foundation conditions, including the presence of stiff soil layers. The response of these platforms due to North Sea storm conditions is also estimated. It is concluded that a simple static analysis of the platform‐foundation system does not necessarily give an accurate prediction of the response under extreme loading conditions. It is proposed that each prototype platform must be assessed on its individual merits, particular attention being given to prevailing geotechnical conditions.
A mathematical model to predict the inelastic response of a steel frame: Establishment of parameters from shaking table experiments
Authors: Matzen Vernon C. , McNtven Hugh D. 
Published: March 2007

AbstractThe purpose of this research is to use data from experiments to formulate a mathematical model that will predict the non‐linear response of a single‐storey steel frame to an earthquake input. The process used in this formulation is system identification.In experiments performed on a shaking table, the frame was subjected to two earthquake motions at several intensities. In each case the frame underwent severe inelastic deformation. A computer program which incorporates the concepts of system identification makes use of the recorded data to establish four parameters in a non‐linear mathematical model. When different amounts of data are used in the program, parameter sets are established which give the best model response for that amount of test data. The resulting sets of parameters reflect the way in which the properties of the structure change during the excitation. However, when the full durations of the different excitations are used, the sets of parameters are almost identical. For each of these sets of parameters, the correlation of the computed accelerations with the measured is excellent, and the shape of the computed displacement response compares very well with the measured response, although the permanent offset of the displacements is not computed exactly.Suggestions are given on how to overcome this deficiency in the mathematical model.
Quality of life in dementia: care recipient and caregiver perceptions of quality of life in dementia: the LASER‐AD study
Authors: Hoe Juanita , Katona Cornelius , Orrell Martin , Livingston Gill 
Published: March 2007

AbstractBackgroundQuality of Life (QoL) is a key outcome in dementia.AimTo compare care recipients' (CR) and caregivers' (CG) views on CRs' QoL and identify determinants.MethodsCRs and CGs completed the Quality of Life ‐ Alzheimer's Disease (QOL‐AD) scale.ResultsOne hundred and ninety‐one CR/CG dyads were interviewed. There were differences between determinants of the CRs and CGs views about QoL. Family‐CGs rated CRs' QoL higher when CRs had fewer depressive symptoms, less irritability, less apathy, less daily living impairment and lived at home. Fewer depressive symptoms, living at home and taking acetylcholinesterase‐inhibitors (AChEI) predicted higher CR rated QoL.ConclusionProxy ratings in dementia do not replicate CRs' views of QoL. This is the first study to employ a validated QoL measure for people with dementia taking AChEIs. Randomised controlled trials are needed before drawing conclusions about their effect on QoL. Interpretation of correlations between QoL and symptoms should be cautious as QoL is designed to reflect the impact of psychological and physical symptoms. Copyright © 2007 John Wiley & Sons, Ltd.
Solitary necrotic nodule of the liver: Contrast‐enhanced sonography
Authors: Wang Yang , Yu Xiaoling , Tang Jie , Li Hua , Liu Liping , Gao Yongyan 
Published: March 2007

AbstractPurpose.To report contrast‐enhanced sonography (CEUS) for solitary necrotic nodule (SNN) of the liver and to assess its clinical value.Methods.CEUS was performed in 17 patients with pathologically proven SNN. Contrast pulse sequencing and the contrast agent SonoVue were used to depict lesion vascularity at a low mechanical index. The enhancement patterns were evaluated in real time.Results.Lesions were depicted as perfusion defects throughout all phases on CEUS.Conclusions:CEUS can be a convenient imaging modality for the differential diagnosis of SNN and may obviate the need for further imaging studies. © 2007 Wiley Periodicals, Inc. J Clin Ultrasound, 2007
Multiparametric high‐resolution imaging of barley embryos by multiphoton microscopy and magnetic resonance micro‐imaging
Authors: Stark Martin , Manz Bertram , Ehlers Alexander , Küppers Markus , Riemann Iris , Volke Frank , Siebert Uta , Weschke Winfriede , König Karsten 
Published: March 2007

AbstractNonlinear optical microscopy and magnetic resonance imaging (MRI) address different properties of the sample and operate on different geometrical scales. MRI maps density and mobility of molecules tracking specific molecular signatures. Multiphoton imaging profits from the nonlinear absorption of light in the focus of a femtosecond laser source stimulating the autofluorescence of biomolecules. As this effect relies on a high light intensity, the accessible field of view is limited, but the resolution is very high (a few hundred nanometers). Here, we aim to link the different accessible scales and properties addressed in the different techniques to obtain a synoptic view. As model specimen we studied embryos of barley. Multiphoton stimulated autofluorescence images and images of second harmonic generation are achieved even down to low magnification (10×), low numerical aperture (N.A. 0.25) conditions. The overview images allowed morphological assignments and fluorescence lifetime imaging provides further information to identify accumulation of endogenous fluorophores. The second, complementary contribution from high‐resolution MR images provides a 3D model and shows the embedding of the embryo in the grain. Images of the proton density were acquired using a standard 3D spin‐echo imaging pulse sequence. Details directly comparable to the low magnification optical data are visible. Eventually, passing from the MR images of the whole grain via low magnification to high resolution autofluorescence data bridges the scale barrier, and might provide the possibility to trace transport and accumulation of, e.g., nutrients from large structure of the plant to the (sub‐) cellular level. Microsc. Res. Tech., 2007. © 2007 Wiley‐Liss, Inc.
MR flow quantification using race: Clinical application to the carotid arteries
Authors: Möller Harald E. , Klocke Hans‐Kristian , Bongartz Georg M. , Peters Peter E. 
Published: March 2007

AbstractReal time MR flow quantification was performed with real time acquisition and evaluation of motion (RACE) in a rigid phantom under steady flow conditions and in the common carotid arteries of 43 subjects aged 24–78 years. Hemodynamic information included the intraluminal velocity distribution during the complete cardiac cycle, the distensibility of the arterial wall, and age‐dependent changes of the flow curves. Systolic peak velocities of 51 ± 33 cm/s and time‐averaged volume flow rates of 4.3 ± 2.0 ml/s were measured in healthy subjects. Flow rates below 3.0 ml/s and the observation of abnormal flow patterns indicated stenoses greater than 70% in the region of the bifurcation (sensitivity: 83.3%; specificity: 93.7%; accuracy: 71.4%). Improvements may be achieved from a combination with MR angiography, providing both functional and morphologic vascular information noninvasively within one observer‐independent examination. MR imaging, therefore, has a strong potential for the diagnosis of critical stenoses in symptomatic patients.
Physiologic motion phantom for MRI applications
Authors: Drangova Maria , Bowman Brett , Pelc Norbert J. 
Published: March 2007

AbstractTo address the need for a complex physiologic motion phantom for use in MR applications, such as the verification of techniques for measuring myocardial motion dynamics and motion insensitive pulse sequences, a computer‐controlled motion phantom has been designed. The phantom, which consists of a deformable silicone gel annulus mounted on a translation stage, can undergo a range of bulk motions and deformations. Available motions include bulk rotation and translation, rotational shear, axial shear, and combinations of some or all of these motions. In this paper, the capability of the phantom to produce accurate constant and time‐varying waveforms is demonstrated. In the current implementation, peak linear translation and rotation rates are 175 mm s−1 and 10 rad s−1, respectively. Cycle‐to‐cycle reproducibility is excellent, with variations of less than .003 radians over the period of hours while under‐going rotational shear. The phantom has been designed in a flexible fashion so that various test objects can be scanned while undergoing bulk translation and can be adapted to produce different deformations.