bluuebunny/crossref_metadata_2025_split huggingface dataset:
Costo de oportunidad en el valor económico del agua superficial para el uso agrícola en el Valle del Río Mala
Authors: Jimenez D. Luis 
Published: April 2024

Se determina el costo de oportunidad de los usos consuntivos y no consuntivos del agua superficial para uso agrícola en el valle de Mala, se aplicaron encuestas a los agricultores, se identificó la curva de demanda y el excedente del consumidor para los usos doméstico, explotación de camarones y recreación. Entre los hallazgos, el 70% de agricultores considera que el problema principal es la deficiente cantidad de agua, por ese motivo, se implementan las "mitas". La superficie agrícola está mayormente dedicada al cultivo del manzano que demanda 9,500 m3 por cosecha de 8 meses. Este cultivo tiene una relación directa con su precio y una relación inversa a la cantidad consumida de agua, existiendo un uso ineficiente. El agua en un huerto de manzana, con tecnología intermedia, tiene un valor, costo del consumo y tarifa de 0.18, 0.10 y 0.02 US$/m3; respectivamente. Calculando los costos de oportunidad, en el uso consuntivo, el agrícola es de US$ 0018/m3 y el doméstico es de US$ 0.032/m3; mientras que en el uso no-consuntivo, la explotación de camarones es de US$ 0.017/m3 y la recreación de US$ 0.016/m3. Llegando a identificar que el uso doméstico es el de mayor valor.
Estudio de las principales características fisicoquímicas y comportamiento del Sanqui (Corryocactus brevistylus subsp. puquiensis (Rauh y Backeberg) Ostolaza) en almacenamiento
Authors: Nolazco C. Diana , Guevara P. Américo 
Published: April 2024

El presente trabajo de investigación, permitió caracterizar físicoquímicamente al sanqui; y determinar su comportamiento en almacenamiento. La pulpa de sanqui presentó la siguiente composición fisicoquímica: humedad 95.2%, proteínas 1.3%, grasa 0.0%, carbohidratos 3.1%, fibra 0.9%, cenizas 0.4%, vitamina C 57.1 mg/100 gr., capacidad antioxidante 474.8 ug. de eq. Trolox/gr., calcio 104.5 ppm, potasio 5566.4 ppm, fósforo 128 ppm, magnesio 145 ppm, acidez 2.3%, pH 2.7, ºBrix 2.9; y la cáscara: humedad 91.6%, proteína 1.4%, grasa 0.0%, carbohidratos 5.6%, fibra 1.7%, cenizas 1.4%, Vitamina C 2.5 mg/100 gr. de fruta, calcio 752 ppm, potasio 1743.9 ppm, fósforo 67 ppm y acidez 0.54%. Se determinó que están presentes las siguientes sustancias fitoquímicas en pulpa: azúcares reductores, lactonas, triterpenos-esteroides, antocianidinas y mucílagos; y en cáscara: azúcares reductores, triterpenos-esteroides y catequinas. De las tres temperaturas de almacenamiento evaluadas: 6ºC, 12ºC y 18°C, se determinó que el sanqui se conserva mejor a 6°C y 90% de H.R.
Estudio de la elaboración de conservas de Trozos de Jurel (Trachurus picturatus murphyi) en aceite vegetal en envases flexibles esterilizables
Authors: Porturas O. Raúl , Juyo V. Víctor 
Published: April 2024

El presente trabajo de investigación trato sobre el procesamiento de jurel (Trachurus picturatus murphyi) bajo la forma de conservas de trozos en aceite vegetal en envases flexibles esterilizables, determinando los principales parámetros de dicho proceso; evaluación de las características sensoriales, químicas y microbiológicas, así como el rendimiento del producto final. La temperatura de cocción fue de 94°C por 30 minutos pasando a un enfriamiento para realizar la respectiva limpieza del pescado cocido y el llenado de los trozos en los envases flexibles esterilizables. En ellos, se agregó el líquido de gobierno que estuvo constituido por 9 g de aceite vegetal, 2.55 g de fibra de trigo, y 1.5 g de sal. El tratamiento térmico se llevó a cabo a un F0 de 6.5 minutos, lo que determinó un tiempo de proceso de 33.45 minutos. Además de ello, se demostró la viabilidad técnica del uso de envases flexibles esterilizables en alimentos marinos, el cual permite obtener un producto con mejores características que los productos tradicionales, como se pudo observar a través de los resultados de las pruebas de preferencia y aceptabilidad realizadas al producto final. La evaluación del producto final dio un producto de buena calidad desde el punto de vista sensorial, químico y microbiológico, obteniéndose un producto innovador para el mercado, que aprovechando un recurso pesquero subexplotado incrementa la oferta exportable del país con productos de alto valor agregado.
Análisis de las exportaciones pesqueras no tradicionales durante 1990 al 2005
Authors: Olaya M. Maria 
Published: April 2024

Las exportaciones pesqueras no tradicionales representaron en promedio el 3.1% del valor nacional durante el periodo de 1990 al 2005. Las exportaciones pesqueras no tradicionales han crecido en el orden del 5% por año habiendo generado 322.5 millones de dólares en el 2005. La jibia, calamar y pota congelada fueron los productos pesqueros no tradicionales que generaron la mayor cantidad de divisas. A los principales países que se exportó fueron: Estados Unidos (20%), España (15%) y Francia (9%). Las exportaciones pesqueras no tradicionales de Chile fueron 6.05 veces más que el Perú en el 2005
Identification and Functional Characterization of Essential Genes Related to Gefitinib Sensitivity in Lung Adenocarcinoma
Authors: Wang Rui , Zhang Lu 
Published: April 2024

Aims:
This study aimed to determine the molecular markers related to gefitinib sensitivity
for guiding the prognosis of lung adenocarcinoma (LUAD) and providing new evidence for
promoting the precise treatment of LUAD.

background:
The World Health Organization stressed the need for molecular markers as diagnostic criteria for lung cancer in 2015 and 2021.

Background:
Lung adenocarcinoma (LUAD) is a prevalent lung cancer subtype with inferior survival
outcomes. However, gefitinib is the first molecular targeted drug approved by Food and
Drug Administration (FDA) to treat advanced LUAD. Gefitinib sensitivity-related gene targets for
LUAD are rarely studied.

objective:
This study was designed to determine the potential molecular markers related to the sensitivity of Gefitinib in lung adenocarcinoma (LUAD), and to study their relationship with tumor biological traits.

Objective:
This study was designed to probe the potential molecular markers related to the sensitivity
of gefitinib in LUAD.

Methods:
The gene expression profiles of LUAD cells in the Genomics of Drug Sensitivity in Cancer
(GDSC) database were used for Weighted Gene Co-expression Network Analysis (WGCNA)
to select the modules most related to gefitinib sensitivity. The Cancer Genome Atlas (TCGA)
database was used to compare the expression of LUAD and para-cancerous tissues. Differentially
expressed genes (DEGs) were then filtered and intersected with the highly linked genes in the module
relevant to gefitinib sensitivity. Univariate Cox regression analysis was conducted to identify
prognostically related genes to LUAD. The correlation between genes and drug IC50 was calculated
by Spearman correlation analysis. Quantitative RT-PCR and immunofluorescence detection
validated hub genes FAM13B and PFKP expressions.

Results:
Among the 10 modules divided by WGCNA, the module with the most significant positive
correlation and the most significant negative correlation with gefitinib sensitivity were found.
FAM13B, PFKP, FGD3, RNASE1, MUC16, GJB5, and GJB3 were hub genes related to gefitinib
sensitivity in LUAD. Significantly, the low expressed FAM13 in LUAD tissues positively correlated
with immune response. At the same time, overexpressed PFKP in the LUAD cohort was related
to an unfavorable prognosis, cell proliferation, and cell cycle. We also found that FAM13B and
PFKP expressions were enhanced in LUAD cell lines.

Conclusions:
This study identified 7 critical genes related to gefitinib sensitivity in LUAD. Functionally,
genes positively correlated with gefitinib sensitivity might regulate the progression of LUAD
through the immune, cell cycle, and metabolic pathways and showed potential effects in predicting
sensitivity to different drugs. These findings help offer a theoretical direction for personalized
treatment of LUAD.
In-vitro Lipolysis, Stability and Pharmacodynamic Study of Cilnidipine Loaded Self-emulsifying Drug Delivery System
Authors: Kadian Renu , Nanda Arun 
Published: April 2024

Aims:
The aim of this research work was to investigate the potential ability of cilnidipine-
loaded-Self-Emulsifying Drug Delivery System (SEDDS) to improve the solubility and oral
bioavailability of cilnidipine.

Background:
The therapeutic value of drugs is constrained by the low oral bioavailability of BCS
class II drugs. In order to improve the solubility and oral bioavailability of poorly water-soluble
drugs, SEDDS are frequently utilised.

Methods:
To develop the cilnidipine-loaded-SEDDS formulation, Canola oil as the oil phase, tween
80 as the surfactant, and PEG 300 as the co-surfactant were used. The SEDDS formulation was
evaluated based on stability study per ICH guidelines, drug precipitation during in-vitro lipolysis
study under fasted and fed state, and in vivo pharmacodynamic study in Wistar rats. The content of
the drug was determined by assay of SEDDS formulation using the official method of cilnidipine.

Results:
The pharmacodynamic study demonstrated that cilnidipine-loaded SEDDS formulation
significantly produced a rapid antihypertensive effect (within 2 h) that lasted for 24 h in comparison
to drug suspension. During the in vitro lipolysis study, the concentration of the drug recovered from
the aqueous phase under both fasted and fed state was more than 90% after 10 minutes, with a minute
amount of drug involved in precipitation. At stability conditions of 30 ± 2°C/65 ± 5%RH for a
duration of six months, the SEDDS formulation was found to be stable. The content of cilnidipine
in the SEDDS formulation was found to be 98.4%.

Conclusion:
A BCS class-II drug's oral bioavailability and dissolution might be improved using the
self-emulsifying drug delivery method.
Development and Outlook for the FDM Printed Nozzle Structure
Authors: Zhang Yuan , Lu Shuai , Yang Yupeng , Zhou Enwen 
Published: April 2024

Abstract::
The nozzle is one of the parts of a 3D printer that cannot be missed because of its widespread
popularity in recent years. The nozzle's structure determines the quality of the printed product;
therefore, selecting a suitable nozzle structure is crucial.
With the advancement of 3D printing technology in recent years, 3D printers have progressively
come under investigation. Examining the design of the nozzle, feeding mechanism, and printing
platform can help to increase the quality of the prints. The design and enhancement of the nozzle
structure are beneficial to the advancement of 3D printing technology since it is one of the key elements
influencing print quality.
Using the research methods, research content, and invention structure of the most recent representative
patents on this nozzle structure, the features and operating principle of the 3D printed nozzle
structure are illustrated.
To classify and examine the nozzle temperature and nozzle clogging that impact the nozzles, a patent
analysis of various types of 3D printing nozzle structures is carried out. Future trends in 3D printing
nozzle structures are also covered.
The issues caused by nozzle work can be resolved to increase product quality and precision by comparing
various 3D printing nozzle structures. This will also lead to the invention of more relevant
patents in the future, including those about printing numerous nozzles and high-strength metals.
Research Progress on Nonlinear Modeling of Electro-Hydraulic Servo Systems and Innovative Applications of Control Strategies
Authors: LI Jianying , Li Donglai , Chen Shuxin , Rong Wang 
Published: April 2024

Abstract:
In various specific application domains, electro-hydraulic servo systems are widely
adopted due to their high power-to-volume ratio, superior dynamic response performance, and extremely
high control accuracy. However, the inevitable presence of nonlinear factors in the system
poses a series of challenges for precise mathematical modeling and the design and application of
different forms of control strategies. This article aims to explore how various control strategies are
specifically implemented to address the nonlinear characteristics of electro-hydraulic servo systems,
building upon the research progress in modeling these systems considering nonlinear factors. Subsequently,
the article summarizes their innovative applications in electro-hydraulic servo systems.
Simultaneously, relevant patents and technologies were reviewed and summarized. The paper provides
a detailed comparison and analysis of various nonlinear modeling methods, with a particular
focus on the significance of neural networks and fuzzy logic control in enhancing the performance of
electro-hydraulic servo systems. The article reveals significant advancements in modern control
strategies in dealing with uncertainties and disturbances within the system, offering new perspectives
and ideas for improving system efficiency and achieving energy resource conservation with technological
progress. The review provides a series of practical recommendations aimed at optimizing the
performance of electro-hydraulic servo systems. Despite progress in multiple research endeavors,
future research should focus on further enhancing system performance and applying these strategies
to a broader range of scenarios.
Green Synthesis of Ag-Doped CuO Nanocomposites Using Honey Solution for Evaluation of their Antimicrobial and Antioxidant Activities
Authors: Gebremichael Tekileab Engida , Muleta Gutta Gonfa , Tadele Kirubel Teshome 
Published: April 2024

Background:
The rise of infectious diseases especially due to drug-resistant microbes
and free radicals has caused a serious threat to public health worldwide. Green synthesized nanomaterials
(NMs) have emerged as promising candidates to minimize the damage due to these problems.
Doping the bioactive and stable silver atom into the biocompatible CuO by capping the nanoparticles
with phytochemicals from honey enhanced the biological activity. The present study aimed
to synthesize Ag- CuO NCs using the honey solution for antimicrobial and antioxidant activity evaluation.

Methods:
The nanoparticles (NPs) and nanocomposites (NCs) were successfully synthesized using
the honey solution and characterized by spectroscopic techniques such as XRD, UV-Vis, FTIR, and
SEM. The role of the secondary metabolites in honey solution is to stabilize the fabricated NMs by
capping.

Results:
The red shift observed with the addition of Ag dopant indicates the narrowing of the CuO
band gap. FT-IR characterization confirmed the presence of various functional group bands in the
synthesized NMs. The spectral band between 900–500 cm−1 displays the presence of metal-oxygen
and metal-metal bonds, confirming the production of pure CuO NPs and Ag-CuO NCs. The fabricated
CuO NPs and Ag-CuO NCs have crystalline structures with crystallite sizes of 14.14 and 17.40
nm respectively. SEM data showed that CuO NPs are spherical and Ag-CuO NCs have a mixture of
spherical and cubic shapes. The NMs displayed concentration-dependent biological activities.

Conclusion:
The successful incorporation of silver into the crystal lattice of CuO integrated with
the presence of secondary metabolites on the surface improved the potential. Hence, the prepared
NMs may have pharmaceutical applications in the future with some modifications for the enhancement
of their potential.
The Application Theory of Planned Behavior to Predict an Indonesian Muslim Student’s Intention to Buy Halal Foods in Taiwan
Authors: Ardiyanto Anang Nur , Lin Chun-Nan , Maulidah Silvana , Moh. Shadiqur Rahman  , Shaleh Mohammad Ilyas 
Published: April 2024

There are many of foreign students who studying abroad are certainly present an opportunity in it self. Food business become one of the emerging opportunities yet have to address consumer needs. An international student who wants to buy food surely have their own criteria. It is not only about the type and taste of the food but also the other aspect that they need to pay attention the most related to the status of halal food for them who become a Muslim. Halal food are those any kinds of various foods that are allowed to be eaten and drunk as long as it is suit with the provisions of Islamic law. This study uses Theory of Planned Behaviors to find out the best variables in predicting the purchase intention of halal foods in Taiwan specifically for an Indonesian Muslim students in Taiwan. Online questionnaire using Google Forms was used to predict for amount 342 an Indonesian Muslim students participate as the research sampling. This research used SEM PLS analysis using WarpPLS 7.0 software. For the result, Theory of Planned Behavior able to be used as a variable to predict the level of purchase intention in halal foods. The Attitude and Subjective Norm has significant result yet the perceived behavioral control has strongly significant results. The last one is about the religiosity that could be used by examine the purchase intention for halal foods as an intervening or mediating variable for this research.
Relación médico/paciente: factores que la han distorsionado
Authors: C E Rougier 
Published: April 2024

Antes de analizar los mismos aclaro que no sé si los factores que considero están dispuestos en el mejor orden y quizás también hay algún otro factor que no he considerado.
Dicho esto, refiero lo siguiente
El advenimiento de la tecnología caló muy hondo en el quehacer médico y su aporte para alcanzar un diagnóstico de manera rápida y también efectiva tentó a los colegas a obviar o abreviar, en la consulta, los pasos habituales de la misma. Los médicos de antaño, sin estas posibilidades, se veían obligados a transitar el camino de la semiología clásica donde el primer elemento de este recorrido era y sigue siendo la anamnesis. Si la misma fue realizada de manera exhaustiva, aún hoy, se dice que con sólo esta herramienta se alcanza, en los actos médicos, un diagnóstico certero hasta en el sesenta por ciento de los mismos. A mí se me antoja pensar, que una anamnesis llevado a cabo con esas características vendría a representar el principal objetivo que se propone incentivar lo que ahora, se ha dado en llamar medicina narrativa.
Strategi Literasi Budaya dan Kewargaan Melalui Peningkatan Variasi Sumber Belajar di Desa Budaya Bangunjiwo
Authors: Setyawati Adella Puspa , Aulia Syifa Siti 
Published: April 2024

AbstractCultural and civic literacy is very important in the era of globalization to maintain the local culture that becomes the identity of the nation. However, cultural and civic literacy is considered less competitive and studies are still minimal in its development. Bangunjiwo Village as a cultural village status is one example of the implementation of cultural and civic literacy. The type of research used is qualitative which uses data as material for analysis and is the narrative and descriptive approach. Data collection of observations, interviews, and documentation then triangulate techniques. The results of research on cultural and civic literacy strategies through increasing the variety of quality learning resources are as follows: 1) Access to library reading with facilities. 2) Digital media as a learning resource using websites, youtube, and instagram, 3) Site visits and history with traditional ceremonial activities and new ways of conveying historical stories through dances such as Ambangunjiwo Goa Wurung historical traces from Prince Diponegoro, 4) Traditional games and art exercises by means of children's dolanan festivals become unique events in conveying the diversity of traditional games packaged into dances. 5) Translation of supporting materials through spatial naming using Javanese script.---------------------------AbstrakLiterasi budaya dan kewargaan sangat penting untuk menghadapi era globalisasi untuk menjaga budaya lokal yang menjadi identitas bangsa. Akan tetapi, literasi budaya dan kewargaan dianggap kurang kompetitif serta kajian yang masih minim dalam pengembangannya. Desa Bangunjiwo sebagai status desa budaya menjadi salah satu contoh dalam implementasi literasi budaya dan kewargaan. Jenis penelitian yang digunakan adalah kualitatif yang menggunakan data sebagai bahan analisis dan bersifat naratif dan pendekatan deskriptif. Pengumpulan data cara observasi, wawancara, dan dokumentasi kemudian melakukan triangulasi teknik. Hasil penelitian strategi literasi budaya dan kewargaan melalui peningkatan variasi ragam sumber belajar bermutu, sebagai berikut: 1) Akses bacaan perpustakaan dengan fasilitas. 2) Media digital sebagai sumber belajar menggunakan website, youtube, dan instagram, 3) Kunjungan situs dan sejarah dengan kegiatan upacara adat dan cara baru menyampaikan kisah sejarah melalui tarian seperti Ambangunjiwo Goa Wurung jejak sejarah dari Pangeran Diponegoro, 4) Permainan tradisional dan latihan seni dengan cara festival dolanan anak menjadi acara yang unik dalam menyampaikan keberagaman permainan tradisional dikemas menjadi tarian. 5) Penerjemahan bahan penunjang melalui cara penamaan tata ruang menggunakan aksara jawa.
Developing Citizenship Attitudes and Skills For Civil Engineering Graduates Through Problem-Based Learning Model Approach
Authors: Frans Pieter Lourens , Abdin Maslan , Jakob Juvrianto Chrissunday 
Published: April 2024

AbstrakSikap dan keterampilan kewarganegaraan merupakan hal yang krusial dalam menghadapi tantangan dunia kerja. Dengan pendekatan Model Problem-Based Learning lulusan Teknik Sipil Politeknik Negeri Ambon dapat mengembangkan sikap dan keterampilan secara konkret melalui pengalaman praktis. Dengan demikian, penelitian ini memiliki relevansi yang signifikan untuk mempersiapkan lulusan dalam menghadapi perubahan zaman dan tuntutan dunia kerja yang semakin dinamis. Penelitian menggunakan pendekatan mixed method yaitu penggabungan data penelitian kuantitatif dan kualitatif, Hasil penelitian yang didapat yaitu dari 19 mahasiswa yang mengikuti pembelajaran nilai rata-rata (Mean) hasil belajar mahasiswa pada variabel sikap sebesar 3,47 selanjutnya variabel keterampilan sebesar 3,53. pembelajaran dengan pendekatan model project based learning menunjukkan dampak positif dengan penilaian baik dan baik sekali, pada sikap mahasiswa mampu menggagas alternatif solusi, kontribusi dan menunjukkan integritas. Pada keterampilan mahasiswa mampu membangun jejaring merefleksikan hal-hal selama proses, memiliki semangat untuk terus memperbaiki lebih baik, mengimplementasikan solusi dan memiliki inisiatif untuk perbaikan bersama.--------------------AbstractHaving the right attitudes and abilities related to citizenship is essential when it comes to dealing with the problems of the professional sphere. The Problem-Based Learning Model enables Civil Engineering graduates from Politeknik Negeri Ambon to cultivate tangible attitudes and abilities via hands-on experience. Therefore, this research holds great importance in equipping graduates to confront the evolving circumstances and the progressively dynamic requirements of the professional sphere. The study employed a hybrid methodological approach, specifically integrating both quantitative and qualitative research data. The research findings were derived from a sample of 19 participants who participated in the study. The mean value of student learning outcomes for the attitude variable was 3.47, while for the skill variable it was 3.53. Implementing a project-based learning paradigm has been found to have a favourable effect on students' attitudes, as evidenced by their ability to provide innovative ideas, actively contribute, and demonstrate integrity, leading to positive assessments. Regarding talents, students possess the ability to establish connections, engage in reflective thinking, have a persistent drive for self-improvement, effectively execute solutions, and exhibit proactive behaviour towards mutual enhancement.