bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical characteristics of carriers of pathogenic LDLR and АРОВ mutations
Authors: Kim Z. F. , Galyavich A. S. , Sadykova D. I. , Nurieva L. M. , Kim E. S. 
Published: February 2024

Aim. To analyze the clinical characteristics of carriers of pathogenic LDLR and АРОВ mutations, as well as the prognostic value of Dutch Lipid Clinic Network Score (DLCNS) as applied to carriage of АРОВ or LDLR.Material and methods. The study included 1233 outpatient lipid clinic patients. Biomaterial samples from 421 patients with the hereditary dyslipidemia were studied using Next Generation Sequencing (NGS) to identify carriage of familial hypercholesterolemia (FH)-associated genes (LDLR, АРОВ, PCSK9, LDLRAP1), as well as polymorphism of the APOE gene. Statistical processing was performed using descriptive statistics methods.Results. According to the data obtained, the most significant predictors of pathogenic LDLR mutations are the levels of total cholesterol, low-density lipoprotein cholesterol (LDL-C), family history of coronary artery disease (CAD), and previous coronary artery bypass grafting. The level of LDL-C, family history of cerebrovascular accident or CAD, and arcus senilis were more significant for verifying the carriage of pathogenic АРОВ mutations. Using screening potential carriers of FH using the DLCN or Simon-Broome diagnostic criteria, the probability of FH may be underestimated due to the discrepancy between the scale criteria and the prognostic contribution of clinical or anamnestic data. These scales do not take into account the estrogen status of potential female carriers of FH.Conclusion. Thus, diagnostic criteria for identifying potential FH vary among different patient groups. Their diagnostic significance depends on sex, and in women, on reproductive status. Only part of DLCN and Simon-Broome criteria can be applied to assess the FH likelihood, and to a greater extent for carriage of LDLR, but not АРОВ.
Proksimat dan profil asam amino kerang bulu (Anadara antiquata) asal Desa Ohoiletman Kabupaten Maluku Tenggara
Authors: Kaya Adrianus Orias Willem , Wattimena Martha Loana , Nanlohy Esterlina Elisabeth Elsina Martha , Lewerissa Sherly 
Published: February 2024

Kerang bulu merupakan salah satu organisme laut yang memiliki nilai gizi tinggi tapi belum dikelola dan dimanfaatkan secara optimal di Kabupaten Maluku Tenggara, Provinsi Maluku. Tujuan penelitian adalah menentukan nilai proksimat, morfometrik, rendemen, dan profil asam amino daging kerang bulu. Pengujian sampel penelitian menggunakan uji proksimat, morfometrik, perhitungan rendemen dan jumlah asam amino menggunakan high performance liquid chromatrografi (HPLC). Nilai proksimat kerang bulu, yaitu kadar air 77,79%; protein 13,08%; lemak 5,33%; abu 1,82%; dan karbohidrat 1,98%. Nilai rata-rata morfometrik kerang, yaitu panjang 5,25 cm; lebar 4,58 cm; tinggi 3,48 cm dan berat 46,81 g dengan rendemen 2,53%. Asam amino berjumlah 18 jenis yang terdiri atas 9 asam amino esensial dan 9 asam amino nonesensial dengan jenis asam amino esensial tertinggi, yaitu lisina 5,03%.
Bizitzaren heriotza: dolu gestazionala bizi duten emakumeen haurdunaldiaren eta amatasunaren bizipena
Authors: Sein Lasa Oihana , Izaguirre Choperena Ainhoa 
Published: February 2024

Jarraian aurkezten den ikerlanak heriotza gestazionala bizi duten emakumeek dolu prozesuan pairatzen dituzten ondorio psikologikoak aztertzea du helburu. Hori dela eta, hasteko, heriotza gestazionalaren testuingurua osatzen duten elementuen inguruko informazioa bildu da iturri ez zuzenekoen bidez. Gaia bere kontestuan kokatu eta autore ezberdinen ideien alderaketa egin ostean, ikerketa kualitatiboarekin jarraitu da. Sei emakumeren bizipenak, esperientziak eta iritziak jaso dira bertan. Elkarrizketetan bildutako informazioa eta lehendik landutako autoreen ekarpen teorikoak aztertzeari esker zenbait ideia ondorioztatu dira, dolu gestazionalaren prozesua bestelako bilakatu dezaketenak, beti ere gizarteak emakumeekiko eta gaiarekiko duen begirada aldatuta.
Jasoa: 2023, uztaila 05; Onartua: 2023, abendua 07.
Influence of in situ Biofloc Production on Bio Growth Performance, Physiological Immune Response, Digestive Enzyme Activity, Nutrient Composition and Disease Resistance of Etroplus suratensis
Authors: Jackqulinwino A. , Ahilan B. , Antony Cheryl , Chidambaram P. , Uma A. , Ruby P. 
Published: February 2024

Backgroud: The present experiment was conducted to investigate the effects of insitu jaggery based biofloc on biogrowth performance, physiological immuno response, digestive enzyme activity, nutrient composition and disease resistance of Etroplus suratensis. Method: The fingerlings of pearlspot, E. suratensis with an average body weight of 5.67±0.08 g was stocked at the rate of 150/m3 in treatment and control system. The insitu biofloc was produced in 2.4 ton capacity outdoor tanks using jaggery as carbon source at two different C: N ratio of viz, 10: 1 (B1) and 20:1 (B2), where clear brackishwater system and without carbon source as control. Result: The levels of ammonia nitrogen, nitrite–nitrogen and nitrate–nitrogen were reduced in the insitu biofloc compared to control while TSS and TS were increased significantly in all insitu biofloc compared to control. The physiological immuno responses such as Respiratory burst test, Myeloperoxidase, serum lysozyme and antioxidant enzymes activity Superoxide dismutase and catalase were found to be significantly higher in B2 at end of the trial. Stress parameters glucose and cortisol were significantly lower in jaggery based biofloc system especially in (B2) C: N 20:1 compared to control. The fishes from the jaggery based biofloc groups possessed significantly (P less than 0.05) higher immune status as compared to control. The digestive enzymes activity such as amylase protease and lipase, of fish was higher in biofloc treatment and lower in control. Compare to control the nutrient composition of E. suratensis was significantly higher in the treatment groups. Moreover, jaggery based insitu fishes showed the lower cumulative mortality rate and Enhanced relative levels of protectio after experimental challenge with A. hydrophila compared to control.
CORRELATION BETWEEN FEMALE JUNIOR HIGH SCHOOL STUDENTS KNOWLEDGE AND BREAST SELF EXAMINATION BEHAVIOR
Authors: Karni Winda Ayu Juwita , Rostianingsih Dewi , Sirait Lenny Irmawaty 
Published: February 2024

Background : Breast cancer is a painless lump, can develop and invade surrounding breast tissue then spread to nearby lymph nodes or to other organs in the body. The high mortality rate of breast cancer is due to a lack of knowledge about breast cancer and early detection so that it comes to health services at late stage. As recommended by the government, the most effective screening method is Breast Self Examination which is very easy but many teenagers do not know this method. The aim of this study is to know correlation between students knowledge and Breast Self Examination Behavior. Method : Descriptive quantitative reasearch through a cross sectional approach. Population in this study were 218 female students at Ananda Junior High School Bekasi City West Java in 2022 with 141 students for sample using simple random sampling technique. Research instruments using questionnaires about knowledge of pathophysiology and breast cancer prevention as independent variable and Breast Self Examination behavior as a dependent variable using the chi square statistical test. Results : Majority as many 91.5% of Ananda Junior High School students had never done Breast Self Examination, had poor knowledge about the pathophysiology of breast cancer (93.6%) and breast cancer prevention (83.7%). Then obtained a p value of 0.000 (p < 0.05) which means that there is a significant correlation between knowledge about the pathophysiology and breast cancer prevention with Breast Self Examination behavior. Conclusion : The proportion of Breast Self Examination behaviour of Ananda Bekasi junior high school students is very low (8.5%). Most respondents had less knowledge about the pathophysiology of breast cancer (93.6%) and breast cancer prevention (83.7%). Suggestions: Conduct ongoing research to see any changes in respondent behavior in the future.
FACTORS RELATED TO INCIDENCE OF MALNUTRITION IN UNDER FIVE CHILDREN
Authors: Okta Jaa Oktafa Once , Mustafa Annasari , Yudianti Ika 
Published: February 2024

Background: Malnutrition is one of the main nutritional problems in Indonesia and East Java. Malnutrition is the cause of more than 1/3 of 9.2 million deaths in children under the age of 5 in the world. Toddlers are a very vulnerable group related to nutrition in society. If the nutrition of children under five is not fulfilled continuously it will cause stunting. Method: This study uses descriptive analysis to overview of the problem of factors related to the incidence of undernutrition in children under five at Posyandu Randugading, Tajinan District, Malang Regency. The sample consisted of 36 children under five using a total sampling technique. This data was obtained from the nutritional status report of the Tajinan Community Health Center which met the nutritional criteria of less than -3 SD to <-2 SD based on the z-score formula. This research instrument used a questionnaire, data collection was carried out by interviews to obtain data on variables Frequency of giving MP-ASI, Infectious diseases, Exclusive breastfeeding, Mother's weight gain during pregnancy, and Number of siblings. The data collection period was carried out on 18 April 2023–25 April 2023. Result: from 36 children showed that 30.55% giving MP-ASI at most was according to the child’s request, children who have had history of an infectious disease 58.33%, exclusive breastfeeding was 50 %, weight gain during pregnancy less as it shouls was 50%, children who have siblirng is more than 2 was 63.89%. Conclusion: Malnutrition children under five year old in Posyandu Randugading, Tajinan District, Malang Regency have characteristic related to feeding meals was most of them according to the child’s request, majority children have history of an infectious disease, Mother wight gain during pregnancy lower as it should, majority children have more than 2 sibling.
Diagenesis and Hydrocarbon Generation in the Monterey Formation, Huasna
Basin, California
Authors: Kablanow Raynold I. , Surdam Ronald C. 
Published: February 2024

Abstract
The Huasna Basin, and adjacent basins developed along the San Luis Obispo transform, a major branch of the San Andreas fault system. The cessation of Gorda Plate subduction and the initiation of transform fault motion between the Pacific and North American plates at the triple junction greatly influenced the thermal history of coastal California. As a consequence of this tectonic framework, abnormally high heat flow persisted for several million years in the Huasna Basin, creating a thermal regime capable of producing hydrocarbons. The diagenesis and hydrocarbon generation in the Monterey Formation in the context of this tectonic and thermal history are the subject of this paper.
Four main diagenetic relationships are observed: 1) the transformation of biogenic opal to quartz has occurred in the basin center, but not at the margins; 2) mixed layer expandable clays decrease with increasing depth of burial; 3) authogenic kaolinite and migrated hydrocarbons have nearly a 1:1 correlation; 4) feldspar grains are etched at all depths in the subsurface, whereas the feldspar in surface sections shows intense dissolution.
Conventional organic geochemical techniques such as pyrolysis, thermal alteration indices and elemental analysis indicate immature to low levels of thermal maturity. However, thermal models developed for the basin demonstrate that the Monterey Formation has been in the liquid window for several million years. This apparent irreconcilable difference can be explained if either 1) the early hydrocarbons generated are mainly long chained (“heavy”) hydrocarbons and/or 2) the light hydrocarbon fraction has escaped. Asphaltic seeps at the margins of the basin and oil shows encountered during drilling suggest that hydrocarbons have been and probably still are being generated in the Huasna Basin.
Zero Knowledge Bi-Party Computation Using Oblivious Transfers for Recommender Systems
Authors: Rajagopalan Anirudh , Singh Kunwar , Jayashrri Balaji , John Anu E 
Published: February 2024

Abstract
Behavioural recommendations, utilizing data collected from online activity, is invaluable in helping advertisers reach the most suitable audience for their products. However, user privacy could be better protected if it could be accomplished without collecting a particular individual’s data. \\
We provide a generic construction to leverage the classical Zero-Knowledge (ZK) protocol into a composable oblivious transfer (OT) protocol, preserving the ZK protocol's round-complexity properties and security guarantees in the resulting OT protocol. Incorporating Fuzzy Logic, this amalgamation ensures that users’ sensitive, personal and private data is always kept secure when communicating with the recommender systems while not compromising the capacity of these systems to create cohorts of similar individuals.
Generative AI in Academic Research: A Descriptive Study on Awareness, Gender Usage, and Views among Pre-Service Teachers
Authors: Nyaaba Matthew , Kyeremeh Patrick , Majialuwe Eric Kojo , Owusu-Fordjour Collins , Asebiga Esther , A-ingkonge Barnabas 
Published: February 2024

Abstract

This study investigated the engagement of Pre-Service Teachers (PSTs) with Generative AI (GAI) tools in their research projects, focusing on their awareness, source of awareness, usage pattern based on gender, and views of GAI tools in academic research. We adopted a descriptive survey method to collect data from one hundred and four PSTs across five institutions in Ghana using a five-point Likert-type survey instrument, which included an open-ended question for data collection. The quantitative data were analyzed using means, frequencies, percentages, standard deviations, and an independent samples t-test. The findings revealed that PSTs are familiar with GAI tools, especially ChatGPT and Google Bard. They learned about these tools through personal searches, recommendations from friends, and social media platforms. The PSTs used these tools in writing all chapters of their research projects, with theIntroduction Chapterbeing the most common area of application, followed by theDiscussion and Findings Chapter, theLiterature Review Chapter,Methodology, andSummary and Conclusion. We also identified a significant gender disparity in the use of GAI tools, with male PSTs exhibiting a higher frequency of use compared to their female counterparts. Nonetheless, both genders expressed a positive attitude towards GAI tools in academic research, noting among other benefits that these tools provided them with confidence and independence in their research writing. However, they also recognized inaccuracies in the information provided by GAI tools, which led to skepticism about relying solely on these tools for their research projects. Consequently, they expressed a preference for support from their research supervisors, highlighting the importance of a balanced approach that combines the use of GAI tools with human supervision in academic research. Therefore, we recommend integrating GAI tools into teacher education programs. However, this integration should be complemented with comprehensive guidance on how these tools can be effectively used by PSTs to conduct original and advanced research.
Ecological dynamics of anoxygenic phototrophs in stably redox-stratified waters: Intra and inter-seasonal variability of Lake Cadagno
Authors: Storelli Nicola , Steiner Oscar Sepúlveda , Nezio Francesco Di , Roman Samuele , Buetti-Dinh Antoine , Bouffard Damien 
Published: February 2024

Abstract

Lake Cadagno differs from typical alpine lakes as it is stratified into two water layers that never vertically mix. This stratification creates a niche for the development of primordial anoxygenic phototrophs, which thrive in the chemocline of the lake, forming a characteristic bacterial layer (BL). Yet, the relationship between the temporal variation of meteorological factors that regulate stratification and the development of the BL remains unclear. Here, we explored the intra- and inter-seasonal stability of the water column stratification and ecological dynamics of the anoxygenic phototroph community of the BL over three years. Our continuous monitoring showed that the meromixis of the lake is highly stable, with density stratification seemingly unaffected by external meteorological factors. Further reanalysis of the lake’s recent history substantiated this remarkable stability. In contrast, the community of anoxygenic phototrophs showed significant intra- and inter-seasonal variability, modulated by weather events that primarily impacted light penetration. In fact, an exceptional intra-seasonal light increases in September 2020 led to an overgrowth of purple sulfur bacteria compared to commonly dominant, green ones. At the inter-seasonal level, there is a difference in BL development in July 2021, which was characterized by much precipitation and less light, compared with that in 2019/2020.
A Solvent-free Processed Low-temperature Tolerant Adhesive
Authors: Lan Ya-Qian , Xie Xiaoming , Li Run-Han , Yao Xiaoman , Zhang Jiaqi , Zhang Zilin , Huang Taoping , Jiang Yulian , Chen Yifa , Li Shunli 
Published: February 2024

Abstract

Ultra-low temperature resistant adhesive is highly desired yet scarce for material adhesion for the potential usage in Arctic/Antarctic or outer space exploration. Here we develop a solvent-free processed low-temperature tolerant adhesive with excellent adhesion strength and organic solvent stability, wide tolerable temperature range (i.e. -196 to 55°C), long-lasting adhesion effect (> 60 days, -196°C) that exceeds the classic commercial hot melt adhesives. Notably, manufacturing at scale can be easily achieved by the facile scale-up solvent-free processing, showing much potential towards practical application in Arctic/Antarctic or planetary exploration. One Sentence Summary: We have designed a kind of solvent-free adhesive with excellent low temperature resistance up to -196°C and can be readily scale-up manufactured on a kilogram scale through a solvent-free heat-assisted process.
A Study on Source Identification of Contaminated Soil with total Petroleum Hydrocarbons (Aromatic and Aliphatic) in the Ahvaz Oil Field
Authors: Kazemi Ali , Parvaresh Hossein , Qanateghestani Mohsen Dehghani , Ghasemi Saber 
Published: February 2024

Abstract

Oil industry in Khuzestan province (Southwest Iran) is one of the main reasons contributing to pollution of the environment in this area. Total petroleum hydrocarbons, including both aromatic and aliphatic compounds, are important parameters in creating pollution. The present study aimed to investigate and source of soil contamination by total petroleum hydrocarbons (aromatic and aliphatic) in the Ahvaz oil field in 2022. The soil samples collected from four oil centers (an oil exploitation unit, an oil desalination unit, an oil rig, and a pump oil center). An area outside the oil field was determined as control area. 10 samples with three replicates were taken from each area according to the Standard Methods. Aromatic and Aliphatic compounds were measured by HPLC and GC methods. The PMF model was used to determine the source apportionment of aromatic compounds in soil samples. ERL and ERM indices were also used to assess the level of ecological risk of petroleum compounds in the soil samples. The results showed that Benzo.b.fluoranthene had the highest concentration with an average of 5667.7 ug/kg in soil samples in the Ahvaz oil field. The highest average was found in samples from the pump oil center area at 7329.48 ug/kg, while the lowest was found in control samples at 1919.4 ug/kg. The highest level of aliphatic components was also found in the pump oil center, with a total of 3649 mg/kg. The results of source apportionment of petroleum compounds in soil samples showed that oil activities accounted for 51.52% of the measured aromatic compounds in soil. 38.3% of other measured compounds had anthropogenic origins, and only 10.18% of these compounds were of biotic origin. The analysis of ecological risk indices resulting from the release of aromatic compounds in the environment showed that, except for Fluoranthene, other aromatic compounds in the oil exploitation unit area were above the ERM level (moderate risk range) and at high risk. The results of the study showed that soil pollution by total petroleum hydrocarbons, both aromatic and aliphatic, is at a high level, which is mainly caused by human activities, particularly oil activities.
Hoist missions and seasonal influences on air rescue service helicopters: A descriptive study based on three German helicopters
Authors: Werner Daniel , Dahlmann Philipp , Elsenbast Christian , Schwietring Jens 
Published: February 2024

Abstract

Background
In the German emergency medical services, 67 rescue helicopters and 12 helicopters for rescue and intensive care transport missions provide their services mostly under visual flight conditions. Of these, 10 helicopters are equipped with a rescue hoist. There is limited data on the frequency of hoist operations, tracer diagnoses, and influences such as weather and vacation periods. This study examines hoist deployment frequencies, tracer diagnostics, and the influence of vacation season at three German helicopter sites.
Methods
In the period from 01 Feb. 2018 to 31 Dec. 2021, a total of 1340 hoist missions were retrospectively examined descriptively for the helicopters Christoph 15 (n = 196), Christoph 1 (n = 316), and Christoph Murnau (n = 828) using their electronic mission documentation.
Results
56.89% of the hoist missions were flown during the summer months, with vacation periods having a small effect on Christoph 1 only. Traumatological diagnoses clearly predominated on all three helicopters, with 75.0% on Christoph 15, 78.8% on Christoph 1, and 52.17% on Christoph Murnau. Among the traumatological indications, extremity trauma (39.29%) was the most frequent, followed by spinal injuries (10.71%), traumatic brain injuries (8.67%), and polytrauma (4.59%). Among internal medicine emergencies, collapse/syncope (5.61%) and cardiovascular arrest (3.06%) were the most common, followed by acute coronary syndromes, anaphylaxis, and hypothermia (2.55% each).
Conclusions
Despite the predominance of extremity injuries and syncope/collapse, where risk stratification was the primary concern and complex medical care was usually not required, there were also dynamic and complex emergency events, e.g., cardiovascular arrests, traumatic brain injuries, and anaphylaxis. Not even the Covid-19 pandemic led to a significant shift in distribution. Surprisingly, the influence of vacation periods on the frequency of operations was less pronounced even in tourism-oriented regions. For future research, other aspects need to be studied, such as the impact of severe weather on helicopter operations in the context of climate change, as well as personnel strategy (e.g., 3-person vs. 4-person crews).