bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of Environmental Injustice and Cardiovascular Diseases and Risk Factors in the United States
Authors: Khadke Sumanth , Kumar Ashish , Al‐Kindi Sadeer , Rajagopalan Sanjay , Kong Yixin , Nasir Khurram , Ahmad Javaria , Adamkiewicz Gary , Delaney Scott , Nohria Anju , Dani Sourbha S. , Ganatra Sarju 
Published: March 2024

Background
While the impacts of social and environmental exposure on cardiovascular risks are often reported individually, the combined effect is poorly understood.

Methods and Results
Using the 2022 Environmental Justice Index, socio‐environmental justice index and environmental burden module ranks of census tracts were divided into quartiles (quartile 1, the least vulnerable census tracts; quartile 4, the most vulnerable census tracts). Age‐adjusted rate ratios (RRs) of coronary artery disease, strokes, and various health measures reported in the Prevention Population‐Level Analysis and Community Estimates data were compared between quartiles using multivariable Poisson regression. The quartile 4 Environmental Justice Index was associated with a higher rate of coronary artery disease (RR, 1.684 [95% CI, 1.660–1.708]) and stroke (RR, 2.112 [95% CI, 2.078–2.147]) compared with the quartile 1 Environmental Justice Index. Similarly, coronary artery disease 1.057 [95% CI,1.043‐1.0716] and stroke (RR, 1.118 [95% CI, 1.102–1.135]) were significantly higher in the quartile 4 than in the quartile 1 environmental burden module. Similar results were observed for chronic kidney disease, hypertension, diabetes, obesity, high cholesterol, lack of health insurance, sleep <7 hours per night, no leisure time physical activity, and impaired mental and physical health >14 days.

Conclusions
The prevalence of CVD and its risk factors is highly associated with increased social and environmental adversities, and environmental exposure plays an important role independent of social factors.
Taxonomic notes and new species of Burmomiles and Sanaungulus (Coleoptera, Cantharidae) from northern Myanmar during the late Mesozoic
Authors: Yang Yuxia , Zhao Wei , Liu Haoyu 
Published: March 2024

Abstract
In this study, Poinarelektronmiles Fanti & Damgaard, 2020 is considered as a junior synonym of Burmomiles Fanti, Damgaard & Ellenberger, 2018, since no generic diagnostic differences can be found in their type species except for the elytral length, which is a yet unstable and more ecology-related character. The two hitherto known species of Poinarelektronmiles are transferred to Burmomiles or Sanaungulus Fanti, Damgaard & Ellenberger, 2018, including B. ellenbergeri (Fanti & Damgaard, 2020) comb. nov. and S. cuaroni (Bramanti & Fanti, 2022) comb. nov. Meanwhile, B. dominikiweissbachi (Fanti & Müller, 2022) comb. nov., B. kachinensis (Fanti & Müller, 2022) comb. nov. and B. lethi (Fanti & Damgaard, 2020) comb. nov. are transferred from Sanaungulus. Six Sanaungulus species are suggested to be placed in Cantharidae incertae sedis, including S. electrum Fanti & Müller, 2022, S. franziskaeweissbachae Fanti & Müller, 2022, S. nalae Fanti & Müller, 2022, S. morellii Fanti & Damgaard, 2020, S. rosenzweigi Fanti & Damgaard, 2020 and S. ruicheni (Hsiao & Huang, 2018), due to their absence of antennal appendages in males. The gender identity for S. kirstenaeweissbachae Fanti & Müller, 2022 and S. cuaroni originally defined as females are corrected into males, according to their pectinate antennae. Additionally, four new species, S. marginalis sp. nov., S. longicornis sp. nov., S. elongaticollis sp. nov., and S. undecimus sp. nov., are described and illustrated. These results will significantly complement and expand our knowledge on the Burmite cantharid diversity.
Finding the Right XAI Method—A Guide for the Evaluation and Ranking of Explainable AI Methods in Climate Science
Authors: Bommer Philine Lou , Kretschmer Marlene , Hedström Anna , Bareeva Dilyara , Höhne Marina M.-C. 
Published: March 2024

Abstract
Explainable artificial intelligence (XAI) methods shed light on the predictions of machine learning algorithms. Several different approaches exist and have already been applied in climate science. However, usually missing ground truth explanations complicate their evaluation and comparison, subsequently impeding the choice of the XAI method. Therefore, in this work, we introduce XAI evaluation in the climate context and discuss different desired explanation properties, namely, robustness, faithfulness, randomization, complexity, and localization. To this end, we chose previous work as a case study where the decade of annual-mean temperature maps is predicted. After training both a multilayer perceptron (MLP) and a convolutional neural network (CNN), multiple XAI methods are applied and their skill scores in reference to a random uniform explanation are calculated for each property. Independent of the network, we find that XAI methods such as Integrated Gradients, layerwise relevance propagation, and input times gradients exhibit considerable robustness, faithfulness, and complexity while sacrificing randomization performance. Sensitivity methods, gradient, SmoothGrad, NoiseGrad, and FusionGrad, match the robustness skill but sacrifice faithfulness and complexity for the randomization skill. We find architecture-dependent performance differences regarding robustness, complexity, and localization skills of different XAI methods, highlighting the necessity for research task-specific evaluation. Overall, our work offers an overview of different evaluation properties in the climate science context and shows how to compare and benchmark different explanation methods, assessing their suitability based on strengths and weaknesses, for the specific research problem at hand. By that, we aim to support climate researchers in the selection of a suitable XAI method.

Significance Statement
Explainable artificial intelligence (XAI) helps to understand the reasoning behind the prediction of a neural network. XAI methods have been applied in climate science to validate networks and provide new insight into physical processes. However, the increasing number of XAI methods can overwhelm practitioners, making it difficult to choose an explanation method. Since XAI methods’ results can vary, uninformed choices might cause misleading conclusions about the network decision. In this work, we introduce XAI evaluation to compare and assess the performance of explanation methods based on five desirable properties. We demonstrate that XAI evaluation reveals the strengths and weaknesses of different XAI methods. Thus, our work provides climate researchers with the tools to compare, analyze, and subsequently choose explanation methods.
Nurses’ Anxiety Mediates the Relationship between Clinical Tolerance to Uncertainty and Antibiotic Initiation Decisions in Residential Aged-Care Facilities
Authors: Singh Saniya , Degeling Chris , Drury Peta , Montgomery Amy , Caputi Peter , Deane Frank P. 
Published: March 2024

Aim. Diagnostic uncertainty, risk perceptions, time constraints, and pressure from resident/family members and nurses have been identified as potential barriers to reducing antibiotic prescribing in residential aged-care facilities. The current study investigated the relationship between nurses’ anxiety, clinical tolerance of uncertainty, and behaviors that favor antimicrobial initiation. Methods. A cross-sectional online survey was used to present a clinical vignette with measures of situational anxiety, clinical tolerance to uncertainty using the Physicians Reactions to Uncertainty Scale (adapted for nurses), and self-reported behavior on the Immediate Assessment and Antibiotics scale. The vignette described a hypothetical resident with a potential upper respiratory tract infection. Incremental information was provided with varying levels of symptoms, input from aged-care staff, and the availability of test results. Results. A total of 157 registered and enrolled nurses completed the survey from August 2021 to August 2022. Nurses’ anxiety fully mediated on the relationship between clinical tolerance of uncertainty and perceived need for antibiotics and immediate assessment ( P = 0.004), with 6% of variation explained by the model. Significant effects of clinical tolerance of uncertainty on anxiety ( P < 0.001) and anxiety on antibiotic initiation ( P = 0.002) were found, but there was no significant direct effect between clinical tolerance of uncertainty and antibiotic initiation ( P = 0.34). Conclusions. This is the first study that links perceived need for antibiotics and assessment to nurses’ anxiety and clinical tolerance of uncertainty. Thus, it may be that providing strategies for the management of anxiety related to uncertainty could nullify some processes contributing to inappropriate prescribing in aged-care settings Highlights The impact of non-clinical factors (e.g., resident and family preferences) on prescribing is well-established. There is a gap in the literature regarding the mechanisms through which these preferences are experienced as pressure by prescribers within the unique context of residential aged-care facilities (RACFs). A significant relationship was found between nurses’ anxiety, clinical tolerance of uncertainty, and the perceived need for antibiotics and assessment. As such, there is a need to expand stewardship beyond education alone to include interventions that help nurses manage uncertainty and anxiety and include other stakeholders (e.g., family members) when making clinical decisions in the RACF setting.
Scratching beneath the surface: An evaluation of the management of scabies 2017–2023
Authors: Broster Bryony , Clarke Amanda , Iwuji Collins , Soni Suneeta 
Published: March 2024

Introduction Possible resistance to recommended treatments for scabies has emerged recently. In response to anecdotal reports of a recent increase in treatment failure with permethrin, the British Association for Sexual Health and HIV (BASHH) released a statement alerting members to this. Aims To examine attendances and the treatment pathways for scabies cases seen at local sexual health clinics. Methodology A case note review of scabies attendances between January 2017 and December 2023 was conducted. Data collected included patient demographics, clinical information, and scabies treatment histories. Statistical analysis was performed. Results 143 patients attended with scabies. The number of scabies cases did not appear to increase significantly from 2017 to 2023 ( p = .09). There was significant increase in median number of treatments per case per year over time ( p = .013). The number of individuals needing second-line treatments increased significantly over time ( p-trend < 0.001). Discussion Individuals with scabies are requiring more treatments to clear infection. Use of ivermectin has risen in the last year suggesting that second-line treatment is increasingly needed for eradication. Whilst treatment failure may be due to non-compliance with treatment and decontamination efforts for both index and contacts, the more recent change in findings could be attributed to a fall in permethrin efficacy.
Glaucoma awareness, anxiety and its impact on patients undergoing visual field testing and optical coherence tomography
Authors: Maheshwari Devendra , Pillai Madhavi Ramanatha , George Koshy T Nithin , Nagdev Nimrita , Gunaselvi D Ranitha , Uduman Mohammed Sithiq , Kader Mohideen Abdul , Ramakrishnan Rengappa 
Published: March 2024

Purpose To assess the effect of Glaucoma awareness, knowledge, and anxiety on patients under visual field analysis by Humphrey's visual field analyzer (HFA) and optical coherence tomography(OCT) Methods This prospective comparative cohort study included glaucoma patients undergoing HFA (Group A)( n = 150) and OCT(Group B) ( n = 150). Each group consisted of 75 newly diagnosed patients and 75 patients who were on follow-up. Participants completed State trait anxiety inventory form Y2(STAI) before and after the test to assess pre-test and intra-test anxiety. Another validated and structured questionnaire was used to assess patient awareness and knowledge of glaucoma. Anxiety scores were used to make correlations and comparisons between the two groups and also against visual field reliability indices. The impact of awareness on anxiety scores and its correlation with reliability indices were also determined. Results Overall pretest and intratest anxiety scores in patients undergoing HFA were 52.39(9.5) and 52.45(8.6)and OCT 53.04(8.0) and 53.83(8.2) respectively.Pretest anxiety was less in follow-up patients of both groups(Group A-51.04,Group B-52.72).There was no statistically significant difference between the groups(pretest p = 0.52,Intratest p = 0.15). Anxiety score was found to be significantly high in female participants(54.07, p = 0.01)and those without awareness( p < 0.001). Patients with education of graduation and above in group B had significantly lower anxiety scores( p = 0.007). Conclusion Anxiety levels induced by both diagnostic modalities HFA and OCT appear to be similar and it does not affect the reliability indices.Anxiety score was higher in female participants and participants lacking disease awareness.
Effects of Eccentric Versus Concentric Strengthening in Patients With Subacromial Pain Syndrome: A Randomized Controlled Trial
Authors: Karabay Damla , Yeşilyaprak Sevgi Sevi , Erduran Mehmet , Ozcan Cem 
Published: March 2024

Background: Subacromial pain syndrome (SPS) is the most common cause of shoulder pain. Therapeutic exercise is the first-line treatment for SPS; however, the ideal exercise type remains unclear. Here, we compared the effects of eccentric and concentric strengthening in patients with SPS. Hypothesis: Adding isolated eccentric strengthening to a multimodal physiotherapy program (MPP) would lead to greater improvements in outcomes compared with either MPP alone or adding isolated concentric strengthening to the MPP. Study Design: Randomized controlled trial. Level of Evidence: Level 2. Methods: A total of 45 patients were randomized to eccentric strengthening (ESG), concentric strengthening (CSG), and control (CG) groups; all groups received the MPP. The strengthening groups also performed group-specific strengthening. Shoulder pain, abduction and external rotation (ER) strength, joint position sense (JPS), the Constant-Murley Score (CMS), and the Disabilities of the Arm, Shoulder and Hand score were collected at baseline, after 12 weeks of treatment, and at week 24. Results: For CMS, ESG exhibited a greater, but not clinically meaningful, improvement than CSG and CG ( P < 0.05). Eccentric abduction strength increased in ESG compared with CG. From baseline to follow-up, abduction strength increased in ESG compared with CSG and CG. Eccentric abduction strength increased in CSG compared with CG. JPS at abduction improved in the ESG compared with CG. Other between-group comparisons were not significant ( P > 0.05). Conclusion: In SPS, eccentric strengthening provided added benefits, improving shoulder abduction strength and JPS at abduction, and was superior to concentric strengthening for improving shoulder abduction strength. Neither strengthening approach had an additional effect on shoulder function, pain, ER strength, or rotational JPS. Clinical Relevance: Clinicians could implement eccentric strengthening as a motor control retraining for strength and proprioception gain rather than for pain relief and reducing disability.
Practice patterns in reporting and documentation of Charles Bonnet syndrome: a retrospective review following COVID-19
Authors: Abdulhussein Dalia , Jones Lee , Dintakurti Sri Harsha , Moosajee Mariya 
Published: March 2024

Background: Charles Bonnet syndrome (CBS) is characterized by visual hallucinations occurring in people with visual impairment. CBS can negatively impact psychological well-being, and the COVID-19 pandemic period was associated with an exacerbation of symptoms. Objectives: To compare clinical practice patterns and reporting of CBS at a tertiary eye care center between an interval prior to the COVID-19 pandemic and an interval during the pandemic. Design: Retrospective chart review. Methods: A search of electronic medical records for all suspected CBS cases was conducted between 1 March 2019 and 29 February 2020 (prior pandemic interval) and between 1 September 2020 and 29 August 2021 (peri-pandemic interval). Data retrieved from records included patient demographics, visual acuity at the time of CBS onset, type of hallucinations, reporting healthcare professional, management strategies and patient-reported impact of hallucinations. Results: In total, 223 appointments referred to CBS in 156 patients at the prior interval, while 239 appointments referred to CBS in 155 patients at the peri-pandemic interval, representing 0.07% and 0.09% of all hospital attendance, respectively. Clinical subspecialty where CBS was most commonly reported was medical retina, and a greater proportion of patients at both time intervals were female. Types of hallucinations, management strategies and patient-reported impact were seldom reported, although documentation improved at the latter interval. Conclusion: Practice patterns and patient characteristics were similar between the two intervals; however, subtle differences suggest a growing awareness of CBS. Targeted interventions in high-burden clinical subspecialties may encourage reporting and improve documentation of CBS.
A multicenter study of venetoclax-based treatment for patients with Richter transformation of chronic lymphocytic leukemia
Authors: Hampel Paul J. , Swaminathan Mahesh , Rogers Kerry A. , Parry Erin M. , Burger Jan A. , Davids Matthew S. , Ding Wei , Ferrajoli Alessandra , Hyak Jonathan M. , Jain Nitin , Kenderian Saad S. , Wang Yucai , Wierda William G. , Woyach Jennifer A. , Parikh Sameer A. , Thompson Philip A. 
Published: March 2024

Abstract
Patients with chronic lymphocytic leukemia (CLL) who develop Richter transformation (RT) have a poor prognosis when treated with chemoimmunotherapy regimens used for de novo diffuse large B-cell lymphoma. Venetoclax, a BCL2 inhibitor, has single-agent efficacy in patients with RT and is potentially synergistic with chemoimmunotherapy. In this multicenter, retrospective study, we evaluated 62 patients with RT who received venetoclax-based treatment outside of a clinical trial, in combination with a Bruton tyrosine kinase inhibitor (BTKi; n=28), rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone (R-CHOP) (n=13), or intensive chemoimmunotherapy other than R-CHOP (n=21). The best overall and complete response rates were 36%/25%, 54%/46%, and 52%/38%, respectively. The median progression-free and overall survival estimates for the same treatment groups were 4.9/14.3 months, 14.9 months/not reached, and 3.3/9 months, respectively. CLL with del(17p) was associated with a lower complete response rate in the total cohort (odds ratio [OR] 0.15; 95% confidence interval [CI] 0.04-0.6; p=0.01) and venetoclax-naïve subgroup (OR 0.13; 95%CI 0.02-0.66; p=0.01). TP53 mutated CLL was associated with a lower complete response rate (OR 0.15; 95%CI 0.03-0.74; p=0.02) and shorter progression-free survival (hazard ratio 3.1; 95%CI 1.21-7.95; p=0.02) only in venetoclax-naïve subgroup. No other clinical or baseline characteristics, including prior venetoclax treatment for CLL, showed statistically significant association with outcomes. Grade 3-4 neutropenia and thrombocytopenia events were most frequent with intensive chemoimmunotherapy + venetoclax; grade 3-4 infection rates were similar across treatment groups. In this difficult-to-treat RT patient population, venetoclax-based combination regimens achieved high response rates, with durable remission and survival observed in a subset of patients.
The effects of flow settings during high-flow nasal cannula oxygen therapy for neonates and young children
Authors: Li Jie , Deng Ni , He Wan Jia Aaron , Yang Cui , Liu Pan , Albuainain Fai A. , Ring Brian J. , Miller Andrew G. , Rotta Alexandre T. , Guglielmo Robert D. , Milési Christophe 
Published: March 2024

BackgroundDuring neonatal and paediatric high-flow nasal cannula therapy, optimising the flow setting is crucial for favourable physiological and clinical outcomes. However, considerable variability exists in clinical practice regarding initial flows and subsequent adjustments for these patients. Our review aimed to summarise the impact of various flows during high-flow nasal cannula treatment in neonates and children.MethodsTwo investigators independently searched PubMed, Embase, Web of Science, Scopus and Cochrane forin vitroandin vivostudies published in English before 30 April 2023. Studies enrolling adults (≥18 years) or those using a single flow setting were excluded. Data extraction and risk of bias assessments were performed independently by two investigators. The study protocol was prospectively registered with PROSPERO (CRD42022345419).Results38 406 studies were identified, with 44 included.In vitrostudies explored flow settings’ effects on airway pressures, humidity and carbon dioxide clearance; all were flow-dependent. Observational clinical studies consistently reported that higher flows led to increased pharyngeal pressure and potentially increased intrathoracic airway pressure (especially among neonates), improved oxygenation, and reduced respiratory rate and work of breathing up to a certain threshold. Three randomised controlled trials found no significant differences in treatment failure among different flow settings. Flow impacts exhibited significant heterogeneity among different patients.ConclusionIndividualising flow settings in neonates and young children requires consideration of the patient's peak inspiratory flow, respiratory rate, heart rate, tolerance, work of breathing and lung aeration for optimal care.
Decoding epitranscriptomic regulation of viral infection: mapping of RNA N6-methyladenosine by advanced sequencing technologies
Authors: Fan Xiangdong , Zhang Yitong , Guo Ruiying , Yue Kuo , Smagghe Guy , Lu Yongyue , Wang Luoluo 
Published: March 2024

AbstractElucidating the intricate interactions between viral pathogens and host cellular machinery during infection is paramount for understanding pathogenic mechanisms and identifying potential therapeutic targets. The RNA modification N6-methyladenosine (m6A) has emerged as a significant factor influencing the trajectory of viral infections. Hence, the precise and quantitative mapping of m6A modifications in both host and viral RNA is pivotal to understanding its role during viral infection. With the rapid advancement of sequencing technologies, scientists are able to detect m6A modifications with various quantitative, high-resolution, transcriptome approaches. These technological strides have reignited research interest in m6A, underscoring its significance and prompting a deeper investigation into its dynamics during viral infections. This review provides a comprehensive overview of the historical evolution of m6A epitranscriptome sequencing technologies, highlights the latest developments in transcriptome-wide m6A mapping, and emphasizes the innovative technologies for detecting m6A modification. We further discuss the implications of these technologies for future research into the role of m6A in viral infections.
Graphical Abstract