bluuebunny/crossref_metadata_2025_split huggingface dataset:
Female Corporeality, Magic, and Gender in the Babylonian Talmud
Authors: Murray Michele 
Published: December 2008

AbstractFor the rabbis, female corporeality – and the control of the female body through rules and regulations – was the locus for (decidedly male) rabbinic piety, and a means for the rabbis to workout what constituted ideal maleness. In their constructions of what constituted "male" and "female," the rabbis created a hierarchy in which males – in particular rabbinic males – were at the top of the hierarchy, and females were at the bottom. The focus of this article is the rabbinic taxonomy of human beings as found in the Babylonian Talmud, a multi-layered and edited corpus of Jewish literature dating from the third to the sixth or seventh centuries CE, redacted in its final form in Babylonia. Using what I call a "taxonomical continuum" as a heuristic tool, I explore how the rabbis employed the label of magic in their discourse as a means of expressing gender. I suggest that "male," which for the rabbis was the form of the ideal human being, was at one end of the continuum. The further from the "male" pole a person was placed along the continuum, the less perfect and less ideal – and the more "female" – was that person. I argue that magic was employed as a mechanism for expressing rabbinic perceptions of gender, since the term "magic" has both positive and negative connotations in the Babylonian Talmud. The valence of the term depended on where the individual who performed the supra-natural action in question was found along the rabbinic taxonomic continuum.
Alignment of Hurricane-like Vortices on f and β Planes
Authors: Jones Robert W. , Willoughby Hugh E. , Montgomery Michael T. 
Published: December 2008

Abstract
A nonlinear, two-layer, vortex-tracking semispectral model (i.e., Fourier transformed in azimuth only) is used to study the evolution of dry, but otherwise hurricane-like, initially tilted vortices in quiescent surroundings on f and β planes. The tilt projects onto vorticity asymmetries that are dynamically vortex Rossby waves.
Since the swirling wind in the principal mean vortex used here decays exponentially outside the eyewall, it has an initial potential vorticity (PV) minimum. The resulting reversal of PV gradient meets the necessary condition for inflectional (i.e., barotropic or baroclinic) instability. Thus, the vortex may be inflectionally stable or unstable. On an f plane, the tilt precesses relatively slowly because the critical radius, where the phase speeds of the waves match the mean swirling flow, is far from the center. An alternative Gaussian-like PV monopole that has a monotonic outward decrease of PV is stable to inflectional instability. It has a smaller critical radius and rapid tilt precession. Generally, vortices with fast tilt precession are more stable, as are stronger vortices in higher latitudes.
On a β plane, the interaction between the symmetric vortex and the planetary PV gradient induces β gyres that push the vortex poleward and westward. The interaction between the β gyres and the planetary PV gradient may either create a PV minimum or intensify a minimum inherited from the initial condition. Thus, the nonlinear β effect reduces the ability of the vortex to recover from initial tilt, relative to the same vortex on an f plane. This result contrasts with previous studies of barotropic vortices on f planes, where the linear and nonlinear solutions were nearly identical.
Orographic Enhancement of Precipitation inside Hurricane Dean
Authors: Smith R. B. , Schafer P. , Kirshbaum D. , Regina E. 
Published: December 2008

Abstract
On 17 August 2007, the center of Hurricane Dean passed within 92 km of the mountainous island of Dominica in the West Indies. Despite its distance from the island and its category 1–2 state, Dean brought significant total precipitation exceeding 500 mm and caused numerous landslides. Four rain gauges, a Moderate Resolution Imaging Spectroradiometer (MODIS) image, and 5-min radar scans from Guadeloupe and Martinique are used to determine the storm’s structure and the mountains’ effect on precipitation. The encounter is best described in three phases: (i) an east-northeast dry flow with three isolated drifting cells; (ii) a brief passage of the narrow outer rainband; and (iii) an extended period with south-southeast airflow in a nearly stationary spiral rainband. In this final phase, from 1100 to 2400 UTC, heavy rainfall from the stationary rainband was doubled by orographic enhancement. This enhancement pushed the sloping soils past the landslide threshold. The enhancement was caused by a modified seeder–feeder accretion mechanism that created a “dipole” pattern of precipitation, including a dry zone over the ocean in the lee. In contrast to normal trade-wind conditions, no terrain triggering of convection was identified in the hurricane environment.
The Response of a Weakly Stratified Layer to Buoyancy Forcing
Authors: Pedlosky Joseph 
Published: December 2008

Abstract
The response of a weakly stratified layer of fluid to a surface cooling distribution is investigated with linear theory in an attempt to clarify recent numerical results concerning the sinking of cooled water in polar ocean boundary currents.
A channel of fluid is forced at the surface by a cooling distribution that varies in the down-channel as well as the cross-channel directions. The resulting geostrophic flow in the central region of the channel impinges on its boundaries, and regions of strong downwelling are observed. For the parameters of the problem investigated, the downwelling occurs in a classical Stewartson layer but the forcing of the layer leads to an unusual relation with the interior flow, which is forced to satisfy the thermal condition on the boundary while the geostrophic normal flow in the interior is brought to rest in the boundary layer.
As a consequence of the layer’s dynamics, the resulting long-channel flow exhibits a nonmonotonic approach to the interior flow, and the strongest vertical velocities are limited to the boundary layer whose scale is so small that numerical models resolve the region only with great difficulty. The analytical model presented here is able to reproduce key features of the previous nonlinear numerical calculations.
Additive Noise for Storm-Scale Ensemble Data Assimilation
Authors: Dowell David C. , Wicker Louis J. 
Published: December 2008

Abstract
An “additive noise” method for initializing ensemble forecasts of convective storms and maintaining ensemble spread during data assimilation is developed and tested for a simplified numerical cloud model (no radiation, terrain, or surface fluxes) and radar observations of the 8 May 2003 Oklahoma City supercell. Every 5 min during a 90-min data-assimilation window, local perturbations in the wind, temperature, and water-vapor fields are added to each ensemble member where the reflectivity observations indicate precipitation. These perturbations are random but have been smoothed so that they have correlation length scales of a few kilometers. An ensemble Kalman filter technique is used to assimilate Doppler velocity observations into the cloud model. The supercell and other nearby cells that develop in the model are qualitatively similar to those that were observed. Relative to previous storm-scale ensemble methods, the additive-noise technique reduces the number of spurious cells and their negative consequences during the data assimilation. The additive-noise method is designed to maintain ensemble spread within convective storms during long periods of data assimilation, and it adapts to changing storm configurations. It would be straightforward to use this method in a mesoscale model with explicit convection and inhomogeneous storm environments.
Bow Echo Mesovortices. Part II: Their Genesis
Authors: Atkins Nolan T. , St. Laurent Michael 
Published: December 2008

Abstract
This two-part study examines the damaging potential and genesis of low-level, meso-γ-scale mesovortices formed within bow echoes. This was accomplished by analyzing quasi-idealized simulations of the 10 June 2003 Saint Louis bow echo event observed during the Bow Echo and Mesoscale Convective Vortex Experiment (BAMEX). In Part II of this study, mesovortex genesis was investigated for vortices formed at different stages of convective system evolution. During the early “cellular” stage, cyclonic mesovortices were observed. The cyclonic mesovortices formed from the tilting of baroclinic horizontal vorticity acquired by downdraft parcels entering the mesovortex. As the convective system evolved into a bow echo, cyclonic–anticyclonic mesovortex pairs were also observed. The vortex couplet was produced by a local updraft maximum that tilted baroclinically generated vortex lines upward into arches. The local updraft maximum was created by a convective-scale downdraft that produced an outward bulge in the gust front position. Cyclonic-only mesovortices were predominantly observed as the convective system evolved into the mature bow echo stage. Similar to the early cellular stage, these mesovortices formed from the tilting of baroclinic horizontal vorticity acquired by downdraft parcels entering the mesovortex. The downdraft parcels descended within the rear-inflow jet. The generality of the mesovortex genesis mechanisms was assessed by examining the structure of observed mesovortices in Doppler radar data. The mesovortex genesis mechanisms were also compared to others reported in the literature and the genesis of low-level mesocyclones in supercell thunderstorms.
PAI-1 and functional blockade of SNAI1 in breast cancer cell migration
Authors: Fabre-Guillevin Elizabeth , Malo Michel , Cartier-Michaud Amandine , Peinado Hector , Moreno-Bueno Gema , Vallée Benoît , Lawrence Daniel A , Palacios José , Cano Amparo , Barlovatz-Meimon Georgia , Charrière-Bertrand Cécile 
Published: December 2008

Abstract
Introduction
Snail, a family of transcriptional repressors implicated in cell movement, has been correlated with tumour invasion. The Plasminogen Activation (PA) system, including urokinase plasminogen activator (uPA), its receptor and its inhibitor, plasminogen activator inhibitor type 1(PAI-1), also plays a key role in cancer invasion and metastasis, either through proteolytic degradation or by non-proteolytic modulation of cell adhesion and migration. Thus, Snail and the PA system are both over-expressed in cancer and influence this process. In this study we aimed to determine if the activity of SNAI1 (a member of the Snail family) is correlated with expression of the PA system components and how this correlation can influence tumoural cell migration.

Methods
We compared the invasive breast cancer cell-line MDA-MB-231 expressing SNAI1 (MDA-mock) with its derived clone expressing a dominant-negative form of SNAI1 (SNAI1-DN). Expression of PA system mRNAs was analysed by cDNA microarrays and real-time quantitative RT-PCR. Wound healing assays were used to determine cell migration. PAI-1 distribution was assessed by immunostaining.

Results
We demonstrated by both cDNA microarrays and real-time quantitative RT-PCR that the functional blockade of SNAI1 induces a significant decrease of PAI-1 and uPA transcripts. After performing an in vitro wound-healing assay, we observed that SNAI1-DN cells migrate more slowly than MDA-mock cells and in a more collective manner. The blockade of SNAI1 activity resulted in the redistribution of PAI-1 in SNAI1-DN cells decorating large lamellipodia, which are commonly found structures in these cells.

Conclusions
In the absence of functional SNAI1, the expression of PAI-1 transcripts is decreased, although the protein is redistributed at the leading edge of migrating cells in a manner comparable with that seen in normal epithelial cells.
Tight perioperative glucose control is associated with a reduction in renal impairment and renal failure in non-diabetic cardiac surgical patients
Authors: Lecomte Patrick , Van Vlem Bruno , Coddens Jose , Cammu Guy , Nollet Guy , Nobels Frank , Vanermen Hugo , Foubert Luc 
Published: December 2008

Abstract
Introduction
Acute renal failure after cardiac surgery increases in-hospital mortality. We evaluated the effect of intra- and postoperative tight control of blood glucose levels on renal function after cardiac surgery based on the Risk, Injury, Failure, Loss, and End-stage kidney failure (RIFLE) criteria, and on the need for acute postoperative dialysis.

Methods
We retrospectively analyzed two groups of consecutive patients undergoing cardiac surgery with cardiopulmonary bypass between August 2004 and June 2006. In the first group, no tight glycemic control was implemented (Control, n = 305). Insulin therapy was initiated at blood glucose levels > 150 mg/dL. In the group with tight glycemic control (Insulin, n = 745), intra- and postoperative blood glucose levels were targeted between 80 to 110 mg/dL, using the Aalst Glycemia Insulin Protocol. Postoperative renal impairment or failure was evaluated with the RIFLE score, based on serum creatinine, glomerular filtration rate and/or urinary output. We used the Cleveland Clinic Severity Score to compare the predicted vs observed incidence of acute postoperative dialysis between groups.

Results
Mean blood glucose levels in the Insulin group were lower compared to the Control group from rewarming on cardiopulmonary bypass onwards until ICU discharge (p < 0.0001). Median ICU stay was 2 days in both groups. In non-diabetics, strict perioperative blood glucose control was associated with a reduced incidence of renal impairment (p = 0.01) and failure (p = 0.02) scoring according to RIFLE criteria, as well as a reduced incidence of acute postoperative dialysis (from 3.9% in Control to 0.7% in Insulin; p < 0.01). The 30-day mortality was lower in the Insulin than in the Control group (1.2% vs 3.6%; p = 0.02), representing a 70% decrease in non-diabetics (p < 0.05) and 56.1% in diabetics (not significant). The observed overall incidence of acute postoperative dialysis was adequately predicted by the Cleveland Clinic Severity Score in the Control group (p = 0.6), but was lower than predicted in the Insulin group (1.2% vs 3%, p = 0.03).

Conclusions
In non-diabetic patients, tight perioperative blood glucose control is associated with a significant reduction in postoperative renal impairment and failure after cardiac surgery according to the RIFLE criteria. In non-diabetics, tight blood glucose control was associated with a decreased need for postoperative dialysis, as well as 30-day mortality, despite of a relatively short ICU stay.
Bridge helix and trigger loop perturbations generate superactive RNA polymerases
Authors: Tan Lin , Wiesler Simone , Trzaska Dominika , Carney Hannah C , Weinzierl Robert OJ 
Published: December 2008

Abstract
Background
Cellular RNA polymerases are highly conserved enzymes that undergo complex conformational changes to coordinate the processing of nucleic acid substrates through the active site. Two domains in particular, the bridge helix and the trigger loop, play a key role in this mechanism by adopting different conformations at various stages of the nucleotide addition cycle. The functional relevance of these structural changes has been difficult to assess from the relatively small number of static crystal structures currently available.

Results
Using a novel robotic approach we characterized the functional properties of 367 site-directed mutants of the Methanocaldococcus jannaschii RNA polymerase A' subunit, revealing a wide spectrum of in vitro phenotypes. We show that a surprisingly large number of single amino acid substitutions in the bridge helix, including a kink-inducing proline substitution, increase the specific activity of RNA polymerase. Other 'superactivating' substitutions are located in the adjacent base helices of the trigger loop.

Conclusion
The results support the hypothesis that the nucleotide addition cycle involves a kinked bridge helix conformation. The active center of RNA polymerase seems to be constrained by a network of functional interactions between the bridge helix and trigger loop that controls fundamental parameters of RNA synthesis.
Olanzapine for the treatment of borderline personality disorder: variable dose 12-week randomised double-blind placebo-controlled study
Authors: Schulz S. Charles , Zanarini Mary C. , Bateman Anthony , Bohus Martin , Detke Holland C. , Trzaskoma Quynh , Tanaka Yoko , Lin Daniel , Deberdt Walter , Corya Sara 
Published: December 2008

BackgroundDespite the prevalence and clinical significance of borderline personality disorder, its treatment remains understudied.AimsTo evaluate treatment with variably dosed olanzapine in individuals with borderline personality disorder.MethodIn this 12-week randomised, double-blind trial, individuals received olanzapine (2.5–20 mg/day;n=155) or placebo (n=159) (trial registry: NCT00091650). The primary efficacy measure was baseline to end-point change on the Zanarini Rating Scale for Borderline Personality Disorder (ZAN–BPD) using last-observation-carried-forward methodology.ResultsBoth olanzapine and placebo groups showed significant improvements but did not differ in magnitude at end-point (76.56v. 76.25,P=0.661). Response rates (50% reduction in ZAN–BPD) were 64.7% with olanzapine and 53.5% with placebo (P=0.062); however, time to response was significantly shorter for olanzapine (P=0.022). Weight gain was significantly greater (2.86v. 70.35 kg, P50.001), with higher incidence of treatment-emergent abnormal high levels of prolactin for the olanzapine group.ConclusionsIndividuals treated with olanzapine and placebo showed significant but not statistically different improvements on overall symptoms of borderline personality disorder. The types of adverse events observed with olanzapine treatment appeared similar to those observed previously in adult populations.
Immigrants and borderline personality disorder at a psychiatric emergency service
Authors: Pascual J. C. , Malagón A. , Córcoles D. , Ginés J. M. , Soler J. , García-Ribera C. , Pérez V. , Bulbena A. 
Published: December 2008

BackgroundSeveral studies have suggested that immigrants have higher rates of psychiatric emergency service use and a higher risk of mental disorders such as schizophrenia than indigenous populations.AimsTo compare the likelihood that immigrants (immigrant group) v. indigenous population (indigenous group) will be diagnosed with borderline personality disorder in a psychiatric emergency service and to determine differences according to area of origin.MethodA total of 11 578 consecutive admissions over a 4-year period at a tertiary psychiatric emergency service were reviewed. The collected data included socio-demographic and clinical variables and the Severity of Psychiatric Illness rating score. Psychiatric diagnosis was limited to information available in the emergency room given that a structured interview is not usually feasible in this setting. The diagnosis of borderline personality disorder was based on DSM–IV criteria. Immigrants were divided into five groups according to region of origin: North Africa, sub-Saharan Africa, South America, Asia and Western countries.ResultsMultivariate statistical logistic regression analysis showed that all subgroups of immigrants had a lower likelihood of being diagnosed with borderline personality disorder than the indigenous population independently of age and gender. Furthermore, the rates of borderline personality disorder diagnosis were considerably lower in Asian and sub-Saharan subgroups than in South American, North African, Western or native subgroups.ConclusionsOur results showed that in the psychiatric emergency service borderline personality disorder was diagnosed less frequently in the immigrant group v. the indigenous group. Our results do not support the concept of migration as a risk factor for borderline personality disorder.
Adults with untreated phenylketonuria: out of sight, out of mind
Authors: Murphy Glynis H. , Johnson Sally M. , Amos Allayne , Weetch Eleanor , Hoskin Rosemary , Fitzgerald Brian , Lilburn Maggie , Robertson Lesley , Lee Philip 
Published: December 2008

SummarySome people with phenylketonuria who were born before screening began were never treated and are still alive. Here we report that far fewer people with untreated phenylketonuria were detected than are thought to exist (about 2000). The majority of those traced had high support needs, challenging behaviour and other symptoms of phenylketonuria. No significant differences were found between those who had or had not tried the phenylalanine-restricted diet. A randomised controlled trial is required to examine the effect of trying the low-phenylalanine diet for people with untreated phenylketonuria.
A survey of memory clinic practice in Scotland
Authors: Foy Jane 
Published: December 2008

Aims and MethodA questionnaire survey of all memory clinics in Scotland to obtain information about clinic characteristics, assessment techniques and prescribing practice.ResultsMemory clinics are a common component of old age psychiatry services within Scotland. There is variability in clinic characteristics, assessment techniques and treatment approaches. Most clinicians appear to rely on their own clinical judgement rather than national guidelines when making decisions about investigations and the prescription of anti-dementia medications.Clinical ImplicationsThere is considerable variation in memory clinic practice across the country. Would standardisation of practice ensure equity in service provision/patient care? However, would such standardisation be at the cost of clinical autonomy?
Can trainees contribute to recruitment into specialty training?
Authors: Jauhar Sameer , Bartos Martin , Hacker Thomas , Srireddy Pavan 
Published: December 2008

Aims and MethodsFollowing the 2007 Modernising Medical Careers process, an online survey of applicants for psychiatry training posts in Scotland was undertaken. Views on short-listing, interview, communication and future recruitment were sought, qualitative and quantitative analyses being employed.ResultsOf 200 doctors, 115 responded, representing all regions and grades. Over 75% (n=84) expressed lack of confidence in short-listing. There was no significant difference between responses of successful and unsuccessful candidates (χ2=3.66, d.f.=2, P > 0.05). A total of 45% perceived interviews as invalid (n=55). About two-thirds (66%, n=69) felt communication was poor. Constructive suggestions for 2008 were made.Clinical ImplicationsAlthough highlighting inadequacies in the 2007 process, trainees offered valid suggestions for future recruitment into specialty training, information being obtained quickly and efficiently.
Psychiatric intensive care and low secure units: where are we now?
Authors: Beer M. Dominic 
Published: December 2008

SummaryThe last decade has seen clinicians and policy makers develop psychiatric intensive care units and low secure units from the so-called ‘special care wards’ of the 1980s and 1990s. Psychiatric intensive care units are for short-term care, while low secure units are for care for up to about 2 years. Department of Health standards have been set for these units. A national survey has shown that there are two main patient groups in the low secure units: patients on forensic sections coming down from medium secure units and those on civil sections who are transferred from general psychiatric facilities. Recent clinical opinion has emphasised the important role both psychiatric intensive care units and low secure units play in providing a bridge between forensic and general mental health services.