bluuebunny/crossref_metadata_2025_split huggingface dataset:
Continental Emissions Influence the Sources and Formation Mechanisms of Marine Nitrate Aerosols in Spring Over the Bohai Sea and Yellow Sea Inferred From Stable Isotopes
Authors: Zhao Zhu‐Yu , Zhang Yan‐Lin , Lin Yu‐Chi , Song Wen‐Huai , Yu Hao‐Ran , Fan Mei‐Yi , Hong Yi‐Hang , Yang Xiao‐Ying , Li Han‐Yu , Cao Fang 
Published: March 2024

AbstractThe influence of continental emissions on the origin and formation mechanisms of atmospheric particulate nitrate (ρ‐NO3−) aerosols in the marine boundary layer remains unclear. Here, synchronous observations of nitrogen isotope ratios (δ15N–NO3−) and oxygen isotope anomaly (Δ17O–NO3−) in ρ‐NO3− were conducted across the Yellow Sea and Bohai Sea in Eastern China. Nitrate concentrations, δ15N–NO3− and Δ17O–NO3− exhibited a pronounced north‐to‐south latitudinal gradient. Combined with backward air mass trajectory analysis, the high nitrate concentration and isotopic characteristics in the northern sea area were found to be affected by the continental outflow near China while the low values in the southern sea area were more related to the oceanic inflow. Stable isotope analysis in R (SIAR) indicated that near the northern sea area, the nitrate radicals (NO3) reacted with hydrocarbons (HC) or dimethyl sulfides (DMS) pathway (NO3 + HC/DMS) played a leading role in nitrate production, whereas the NO2 + OH pathway dominated near the southern sea area. Nitrate in the northern seas originated mainly from nitrogen oxides (NOx = NO + NO2, the gaseous precursor of nitrate) emitted from continental sources, especially coal combustion and biomass burning. While closer to the southern seas, the proportion of NOx generated in the marine environment (from ship and biogenic emissions) increased. Overall, the differential relative contributions of continental and marine atmospheric chemistry and NOx sources lead to the spatial distribution characteristics of atmospheric nitrate concentrations and isotopic values over the Yellow and Bohai Seas.
Accounting for Winter Warming Events in the Ecosystem Model LPJ‐GUESS: Evaluation and Outlook
Authors: Pascual D. , Johansson M. , Pongracz A. , Tang J. 
Published: March 2024

AbstractWinter warming events (WWEs) are short‐lasting events of unusually warm weather, occasionally combined with rainfall, which can cause severe ecosystem impacts by altering ground temperatures and water fluxes. Despite their importance, how large‐scale ecosystem models perform in depicting the impacts of WWEs remain largely unknown. The frequency and intensity of WWEs will likely increase further in the future, making it necessary to understand their potential impacts on high‐latitude ecosystems. In this study, we evaluated the ability of the dynamic ecosystem model Lund‐Potsdam‐Jena General Ecosystem Simulator (LPJ‐GUESS) to represent the responses of subarctic ecosystems to future WWEs, and identified model gaps hindering more accurate estimates of these responses. In response to WWEs, the model simulated substantial ground cooling (up to 2°C in winter) due to reduced snow depth (insulation), with rain on snow (ROS) exerting a marginal influence on the ground temperature responses: these modeled responses are in apparent contradiction with the strong ground warming effect of ROS reported in most observational studies. The simulated ground cooling led to changes in biogeochemical fluxes that were substantial and often comparable in magnitude (but often opposite in direction) to those from altered winter climatologies. The mismatch between the modeled and the observed ground temperature responses to WWEs highlights LPJ‐GUESS's current limitations in realistically simulating some of the effects of WWEs. These limitations likely stem from the (a) absence of a surface energy balance, (b) lack of snow‐vegetation interactions, (c) daily time‐step, and (d) simplistic water retention scheme in LPJ‐GUESS.
Reparameterizing Litter Decomposition Using a Simplified Monte Carlo Method Improves Litter Decay Simulated by a Microbial Model and Alters Bioenergy Soil Carbon Estimates
Authors: Juice S. M. , Ridgeway J. R. , Hartman M. D. , Parton W. J. , Berardi D. M. , Sulman B. N. , Allen K. E. , Brzostek E. R. 
Published: March 2024

AbstractLitter decomposition determines soil organic matter (SOM) formation and plant‐available nutrient cycles. Therefore, accurate model representation of litter decomposition is critical to improving soil carbon (C) projections of bioenergy feedstocks. Soil C models that simulate microbial physiology (i.e., microbial models) are new to bioenergy agriculture, and their parameterization is often based on small datasets or manual calibration to reach benchmarks. Here, we reparameterized litter decomposition in a microbial soil C model (CORPSE ‐ Carbon, Organisms, Rhizosphere, and Protection in the Soil Environment) using the continental‐scale Long‐term Inter‐site Decomposition Experiment Team (LIDET) dataset which documents decomposition across a range of litter qualities over a decade. We conducted a simplified Monte Carlo simulation that constrained parameter values to reduce computational costs. The LIDET‐derived parameters improved modeled C and nitrogen (N) remaining, decomposition rates, and litter mean residence times as compared to Baseline parameters. We applied the LIDET litter decomposition parameters to a microbial bioenergy model (Fixation and Uptake of Nitrogen – Bioenergy Carbon, Rhizosphere, Organisms, and Protection) to examine soil C estimates generated by Baseline and LIDET parameters. LIDET parameters increased estimated soil C in bioenergy feedstocks, with even greater increases under elevated plant inputs (i.e., by increasing residue, N fertilization). This was due to the integrated effects of plant litter quantity, quality, and agricultural practices (tillage, fertilization). Collectively, we developed a simple framework for using large‐scale datasets to inform the parameterization of microbial models that impacts projections of soil C for bioenergy feedstocks.
Magnetic Fingerprints for the Paleoenvironmental Evolutions Since the Last Deglaciation: Evidence From the Northwestern South China Sea Sediments
Authors: Sun Qishun , Jiang Zhaoxia , Xiao Chunfeng , Chen Long , Liu Wanxin , He Kuang , Guan Yulong , Zhang Yuzhen , Wang Haosen , Chen Liang , Yin Zhengxin , Li Sanzhong 
Published: March 2024

AbstractRapid global changes since the last deglaciation can be well documented in marginal sea sediments, while isolating individual paleoenvironmental signals is still challenging. Here, we identified magnetic minerals and unmixed their variations in sediments from the northwestern South China Sea to decipher environmental variations since the last deglaciation. The variation in the hematite to goethite ratio indicates a relatively drier mid‐Holocene and a wetter early and late Holocene in the Red River catchment. The position shift and intensity variation of Western Pacific Subtropical High may account for the Holocene precipitation changes. A higher chemical weathering intensity accompanied by a relatively more fine‐grained magnetite input during the last deglaciation suggests decoupling of the Asian Summer Monsoon and chemical weathering in the catchment, which might have been caused by the shelf exposure during the deglaciation. In addition, the relative abundance of biogenic magnetite increased with the sea level and possible deep‐water temperature rise. Therefore, magnetic minerals such as hematite, goethite, detrital and biogenic magnetite are markedly potential fingerprints for continent‐ocean environmental changes.
Significant Midlatitude Bubble‐Like Ionospheric Super‐Depletion Structure (BLISS) and Dynamic Variation of Storm‐Enhanced Density Plume During the 23 April 2023 Geomagnetic Storm
Authors: Aa Ercha , Zhang Shun‐Rong , Zou Shasha , Wang Wenbin , Wang Zihan , Cai Xuguang , Erickson Philip J. , Coster Anthea J. 
Published: March 2024

AbstractThis paper investigates the midlatitude ionospheric disturbances over the American/Atlantic longitude sector during an intense geomagnetic storm on 23 April 2023. The study utilized a combination of ground‐based observations (Global Navigation Satellite System total electron content and ionosonde) along with measurements from multiple satellite missions (GOLD, Swarm, Defense Meteorological Satellite Program, and TIMED/GUVI) to analyze storm‐time electrodynamics and neutral dynamics. We found that the storm main phase was characterized by distinct midlatitude ionospheric density gradient structures as follows: (a) In the European‐Atlantic longitude sector, a significant midlatitude bubble‐like ionospheric super‐depletion structure (BLISS) was observed after sunset. This BLISS appeared as a low‐density channel extending poleward/westward and reached ∼40° geomagnetic latitude, corresponding to an APEX height of ∼5,000 km. (b) Coincident with the BLISS, a dynamic storm‐enhanced density plume rapidly formed and decayed at local afternoon in the North American sector, with the plume intensity being doubled and halved in just a few hours. (c) The simultaneous occurrence of these strong yet opposite midlatitude gradient structures could be mainly attributed to common key drivers of prompt penetration electric fields and subauroral polarization stream electric fields. This shed light on the important role of storm‐time electrodynamic processes in shaping global ionospheric disturbances.
Targeting the innate immune system in pediatric and adult AML
Authors: Perzolli Alicia , Koedijk Joost B. , Zwaan C. Michel , Heidenreich Olaf 
Published: March 2024

AbstractWhile the introduction of T cell-based immunotherapies has improved outcomes in many cancer types, the development of immunotherapies for both adult and pediatric AML has been relatively slow and limited. In addition to the need to identify suitable target antigens, a better understanding of the immunosuppressive tumor microenvironment is necessary for the design of novel immunotherapy approaches. To date, most immune characterization studies in AML have focused on T cells, while innate immune lineages such as monocytes, granulocytes and natural killer (NK) cells, received less attention. In solid cancers, studies have shown that innate immune cells, such as macrophages, myeloid-derived suppressor cells and neutrophils are highly plastic and may differentiate into immunosuppressive cells depending on signals received in their microenvironment, while NK cells appear to be functionally impaired. Hence, an in-depth characterization of the innate immune compartment in the TME is urgently needed to guide the development of immunotherapeutic interventions for AML. In this review, we summarize the current knowledge on the innate immune compartment in AML, and we discuss how targeting its components may enhance T cell-based- and other immunotherapeutic approaches.
Advanced construction strategies to obtain nanocomposite hydrogels for bone repair and regeneration
Authors: Ding Wang , Ge Yuxiang , Zhang Tikai , Zhang Cheng , Yin Xiaofan 
Published: March 2024

Abstract
Bone tissue engineering is pivotal in facilitating bone reconstruction by promoting persistent angiogenesis and osteogenesis. Initially, the hot gel composite hydrogel scaffold technique was employed. However, to address various limitations, numerous gel structures have since been developed, including osteogenic gellan gels, semi-interpenetrating network hydrogels, photoinduced crosslinking methacrylate gels, and supramolecular hydrogels. This review examines the mechanisms, formation principles, and medical benefits of these gel structures. In addition, novel bioengineering techniques to regulate human bone growth are expected to emerge in the future. This work is expected to significantly expedite the advancement of hydrogel membranes in the field of bone repair.
Mediterranean-style dietary interventions in adults with cancer: a systematic review of the methodological approaches, feasibility, and preliminary efficacy
Authors: McHugh Aoife , O’Connell Ellie , Gurd Bridie , Rae Paige , George Elena S. , Kleckner Amber S. , Baguley Brenton J. 
Published: March 2024

Abstract
Background
Cancer and its treatments can lead to excess body fat, decreases in lean mass, cardiotoxicity, and other side effects. The Mediterranean diet (MED-diet) has the potential to improve clinical and supportive care outcomes. The aim of this systematic review was to evaluate the feasibility, safety, and efficacy of the MED-diet on health outcomes in adults with cancer.

Methods
Three databases were searched from inception to February 2023. Eligible studies included randomised controlled trials testing a MED-diet intervention among adults with cancer. Within- and between-group differences for adherence, dietary intake and health outcomes were extracted.

Results
Fifteen studies describing fourteen interventions were included, and there were considerable differences in study design and implementation of the MED-diet. Studies were predominately in women with a history of breast cancer. The MED-diet was safe with no adverse events reported, and feasible with high adherence and/or increases in MED-diet-compliant foods. The MED-diet when applied with an energy restriction below estimated requirements for weight loss demonstrated reductions in body weight (range: −3.9 kg to −0.7 kg). Interventions that showed significant reductions in body weight also improved quality of life. There is limited evidence to evaluating the MED-diet on cardiovascular and inflammatory markers, and heterogenous MED-diet prescriptions impede definitive conclusions on these health outcomes.

Conclusion
The MED-diet was feasible and safe for adults with cancer. There were reported benefits for weight loss following a MED-diet when an energy restriction was applied, however further evaluation to determine the effects on cardiometabolic biomarkers and other outcomes are required.
Demonstration and imaging of cryogenic magneto-thermoelectric cooling in a van der Waals semimetal
Authors: Völkl T. , Aharon-Steinberg A. , Holder T. , Alpern E. , Banu N. , Pariari A. K. , Myasoedov Y. , Huber M. E. , Hücker M. , Zeldov E. 
Published: March 2024

AbstractAttaining viable thermoelectric cooling at cryogenic temperatures is of considerable fundamental and technological interest for electronics and quantum materials applications. In-device temperature control can provide more efficient and precise thermal environment management compared with conventional global cooling. The application of a current and perpendicular magnetic field gives rise to cooling by generating electron–hole pairs on one side of the sample and to heating due to their recombination on the opposite side, which is known as the Ettingshausen effect. Here we develop nanoscale cryogenic imaging of the magneto-thermoelectric effect and demonstrate absolute cooling and an Ettingshausen effect in exfoliated WTe2 Weyl semimetal flakes at liquid He temperatures. In contrast to bulk materials, the cooling is non-monotonic with respect to the magnetic field and device size. Our model of magneto-thermoelectricity in mesoscopic semimetal devices shows that the cooling efficiency and the induced temperature profiles are governed by the interplay between sample geometry, electron–hole recombination length, magnetic field, and flake and substrate heat conductivities. The observations open the way for the direct integration of microscopic thermoelectric cooling and for temperature landscape engineering in van der Waals devices.
A small-molecule TNIK inhibitor targets fibrosis in preclinical and clinical models
Authors: Ren Feng , Aliper Alex , Chen Jian , Zhao Heng , Rao Sujata , Kuppe Christoph , Ozerov Ivan V. , Zhang Man , Witte Klaus , Kruse Chris , Aladinskiy Vladimir , Ivanenkov Yan , Polykovskiy Daniil , Fu Yanyun , Babin Eugene , Qiao Junwen , Liang Xing , Mou Zhenzhen , Wang Hui , Pun Frank W. , Torres-Ayuso Pedro , Veviorskiy Alexander , Song Dandan , Liu Sang , Zhang Bei , Naumov Vladimir , Ding Xiaoqiang , Kukharenko Andrey , Izumchenko Evgeny , Zhavoronkov Alex 
Published: March 2024

Abstract
Idiopathic pulmonary fibrosis (IPF) is an aggressive interstitial lung disease with a high mortality rate. Putative drug targets in IPF have failed to translate into effective therapies at the clinical level. We identify TRAF2- and NCK-interacting kinase (TNIK) as an anti-fibrotic target using a predictive artificial intelligence (AI) approach. Using AI-driven methodology, we generated INS018_055, a small-molecule TNIK inhibitor, which exhibits desirable drug-like properties and anti-fibrotic activity across different organs in vivo through oral, inhaled or topical administration. INS018_055 possesses anti-inflammatory effects in addition to its anti-fibrotic profile, validated in multiple in vivo studies. Its safety and tolerability as well as pharmacokinetics were validated in a randomized, double-blinded, placebo-controlled phase I clinical trial (NCT05154240) involving 78 healthy participants. A separate phase I trial in China, CTR20221542, also demonstrated comparable safety and pharmacokinetic profiles. This work was completed in roughly 18 months from target discovery to preclinical candidate nomination and demonstrates the capabilities of our generative AI-driven drug-discovery pipeline.
Internal stress transfer characteristics of coal–rock medium under concentrated force based on particle flow method
Authors: Wu Yongping , Tang Yepeng , Xie Panshi , Hu Bosheng , Lang Ding , Wang Hongwei 
Published: March 2024

AbstractTo solve the problem that the macroscopic deformation and failure of coal–rock medium under external loads are easy to be observed while the internal stress transfer mode and path are unclear. Based on the discrete element idea, the numerical models for pure coal or rock samples and coal–rock combination samples with different lithologies and combination methods under concentrated force are established by PFC2D software. Then the influence of coal or rock strength and combination methods on the internal stress transfer law and distribution evolution characteristics of coal–rock medium are discussed from the perspectives of macroscopic stress and mesoscopic force chain, respectively. The results showed that under concentrated load, the macroscopic stress transfer paths within pure coal or rock samples and coal–rock combination samples are primarily in the form of ‘point source radiation’. However, when transferring between coal–rock interfaces, there is a certain interface effect. For pure coal or rock samples, differences in lithology does not change the transfer rules and macro distribution patterns of internal stress, but it can cause changes in internal unit transfer stress value and local area transfer direction. For coal–rock combination samples, the greater the difference in lithology between the two sides of the interface, the more likely the interface effect will occur. In addition, the internal stress transfer is also influenced by the relative stratigraphic relationships of coal and rock. When the stress is transferred from a higher-strength rock to a lower-strength coal mass, the interface effect will be more significant. However, regardless of the combination pattern, the locations where significant stress surges occur are always within the higher strength rock mass near the interface. The findings are helpful to understand the mechanical properties and failure mechanism of mining coal and rock mass, and provide a theoretical basis for the study of the mining-induced mechanical behavior of the floor under the action of the coal pillar.
Role of klotho and fibroblast growth factor 23 in arterial calcification, thickness, and stiffness: a meta-analysis of observational studies
Authors: Wungu Citrawati Dyah Kencono , Susilo Hendri , Alsagaff Mochamad Yusuf , Witarto Bendix Samarta , Witarto Andro Pramana , Pakpahan Cennikon , Gusnanto Arief 
Published: March 2024

AbstractThis meta-analysis was conducted to clarify the role of klotho and fibroblast growth factor 23 (FGF-23) in human arterial remodeling across recent studies, in terms of arterial calcification, thickness, and stiffness. A systematic literature search was conducted on five databases for articles up to December 2023. Arterial calcification, thickness, and stiffness were determined using the calcification score and artery affected, carotid intima–media thickness (CIMT), and pulse wave velocity (PWV), respectively. Sixty-two studies with a total of 27,459 individuals were included in this meta-analysis. Most studies involved chronic kidney disease patients. Study designs were mostly cross-sectional with only one case–control and nine cohorts. FGF-23 was positively correlated with arterial calcification (r = 0.446 [0.254–0.611], p < 0.0001 and aOR = 1.36 [1.09–1.69], p = 0.006), CIMT (r = 0.188 [0.02–0.354], p = 0.03), and PWV (r = 0.235 [0.159–0.310], p < 0.00001). By contrast, Klotho was inversely correlated with arterial calcification (r = − 0.388 [− 0.578 to − 0.159], p = 0.001) and CIMT (r = − 0.38 [− 0.53 to − 0.207], p < 0.00001). In conclusion, FGF-23 and Klotho were associated with arterial calcification, thickness, and stiffness, clarifying their role in arterial remodeling processes.
Estrogen receptor activation remodels TEAD1 gene expression to alleviate hepatic steatosis
Authors: Sommerauer Christian , Gallardo-Dodd Carlos J , Savva Christina , Hases Linnea , Birgersson Madeleine , Indukuri Rajitha , Shen Joanne X , Carravilla Pablo , Geng Keyi , Nørskov Søndergaard Jonas , Ferrer-Aumatell Clàudia , Mercier Grégoire , Sezgin Erdinc , Korach-André Marion , Petersson Carl , Hagström Hannes , Lauschke Volker M , Archer Amena , Williams Cecilia , Kutter Claudia 
Published: March 2024

AbstractSex-based differences in obesity-related hepatic malignancies suggest the protective roles of estrogen. Using a preclinical model, we dissected estrogen receptor (ER) isoform-driven molecular responses in high-fat diet (HFD)-induced liver diseases of male and female mice treated with or without an estrogen agonist by integrating liver multi-omics data. We found that selective ER activation recovers HFD-induced molecular and physiological liver phenotypes. HFD and systemic ER activation altered core liver pathways, beyond lipid metabolism, that are consistent between mice and primates. By including patient cohort data, we uncovered that ER-regulated enhancers govern central regulatory and metabolic genes with clinical significance in metabolic dysfunction-associated steatotic liver disease (MASLD) patients, including the transcription factor TEAD1. TEAD1 expression increased in MASLD patients, and its downregulation by short interfering RNA reduced intracellular lipid content. Subsequent TEAD small molecule inhibition improved steatosis in primary human hepatocyte spheroids by suppressing lipogenic pathways. Thus, TEAD1 emerged as a new therapeutic candidate whose inhibition ameliorates hepatic steatosis.