bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel Human Polyomaviruses Discovered From 2007 to the Present: An Update of Current Knowledge
Authors: Fazeli Mohammad Mehdi , Heydari Sirat Sara , Shatizadeh Malekshahi Somayeh 
Published: February 2025

ABSTRACTHuman polyomaviruses (HPyVs) are a diverse group of viruses that typically establish asymptomatic persistent infections in healthy individuals. However, they can lead to severe diseases in immunocompromised patients. The past 15 years have witnessed significant advancements in understanding HPyVs, leading to the discovery of several novel and highly divergent strains. This surge in knowledge raises critical questions about their evolution, tropism, and potential contributions to various diseases. Although HPyVs are generally benign, certain strains can lead to significant health issues under immunocompromised conditions. Since 2007, several novel PyVs have been isolated from humans: Karolinska Institute Polyomavirus (KIPyV), Washington University Polyomavirus (WUPyV), Merkel cell Polyomavirus (MCPyV), HPyV6, HPyV7, Trichodisplasia spinulosa polyomavirus (TSPyV), HPyV9, HPyV10, Saint Louis polyomavirus (STLPyV), HPyV12, New Jersey Polyomavirus (NJPyV), Lyon IARC polyomavirus (LIPyV), HPyV16 and Quebec polyomavirus (QPyV). This review summarises the available data regarding the biology, tissue tropism, epidemiology, and associated diseases of novel HPyVs discovered from 2007 to the present. While some HPyVs are well‐characterised with clear associations to specific diseases, others remain enigmatic, warranting additional investigation into their biology and clinical implications.
Oxalis corniculata‐Derived Bioactive Compounds Target Hormone Receptors in Breast Cancer: HPLC‐ESI‐MS/MS Analysis, Cytotoxicity, and Computational Studies
Authors: Ahamad Tanveer , Khan Mohsin Ali , Khan Mohd Faheem , Ahmad Rumana , Rahman Mohammad Akhlaquer , Siddiqui Sahabjada 
Published: February 2025

AbstractBreast cancer is the leading global health concern for women. This study aimed to evaluate the antiproliferative property of Oxalis corniculata ethanolic extract, phytochemical identification, and in silico analysis of phytomolecules against estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) associated with breast cancer. Phytochemicals of plant extract were analyzed by HPLC‐ESI‐MS/MS and cytotoxicity was evaluated in human breast cancer cells MCF‐7 and MDA‐MB‐231. A molecular docking study was conducted via AutoDock 4 and AutoDock Vina tools and simulation through GROMACS software. Various phenolic acids and flavonoids were identified in the plant extract. MTT assay showed the IC50 value of the extract against MCF‐7 cells was 111.75 µg/mL and for MDA‐MB‐231 cells; it was 157.42 µg/mL, whereas being less‐toxic to normal Vero cells. The molecular docking data revealed that diosmin, kaempferol‐3‐O‐alpha‐L‐rhamnoside, and orientin showed the lowest binding energy with ER (B.E = −9.278 and −10.52 kcal/mol), HER (B.E = −9.828 kcal/mol), and PR (B.E = −8.938 kcal/mol), respectively. MD simulation analysis showed stable interactions of the biomolecules with receptor proteins. The findings of this study indicated that O. corniculata natural products can be used in the development of anticancer drugs in the management of breast cancer.
Phyto‐mechanochemical Synthesis of Copper Ferrite Nanoparticles: Structural, Magnetic, Photocatalytic, and Antibacterial Properties
Authors: Irshad Zohaib , Javaid Sana , Ali Omar Makram , Khan Muhammad Shahid , AlSulami Fatimah Mohammad H. , Almasoudi Afaf , Al‐Ghamdi Azza A. , Banbela Hadeel M. , Hajjar Dina , Makki Arwa A. , Jabeen Tahira , Taj Muhammad Babar 
Published: February 2025

AbstractSustainable nanotechnology is becoming more prominent daily, especially in preparing magnetic nanoparticles like CuFe2O4. This work involves the phyto‐mechanochemical (mechanical and green) synthesis of CuFe2O4 NPs by Spinacia oleracea leaf extract. Various spectroscopic and analytical techniques including FTIR, UV–vis, XRD, SEM, VSM, EDX, and BET, confirmed the formation and characterizations of the CuFe₂O₄ NPs with 26 nm diameter. Results from VSM analysis demonstrated ferromagnetism with high saturation magnetization. At the same time UV–vis spectroscopy showed the optical characteristics of these materials. The photocatalytic properties of CuFe₂O₄ NPs were tested through decoloration of the textile industry pollutant congo red (CR) dye. CuFe₂O₄ NPs showed an effective degradation rate of 89% for CR dye during a 90 min incubation period under their best operating conditions. The degradation mechanism was studied through kinetic measurements utilizing first‐order and Langmuir‐Hinshelwood models. The nanoparticle size and bioactive properties enabled them to demonstrate powerful antibacterial capabilities against Streptococcus and Escherichia coli bacteria. Uniformity is a key feature of phyto‐mechanically synthesized CuFe₂O₄ nanoparticle synthesis while demonstrating their potential for environmental remediation and biomedical research.
Synthesis of 2,4‐Diaminoquinazolines and 2‐Amino‐4‐iminoquinazolines via Substrate‐Controlled Annulation of 2‐Aminobenzonitriles and Carbodiimides
Authors: Porashar Bikoshita , Choudhury Chinmayee , Saikia Anil K. 
Published: February 2025

AbstractAn efficient methodology for the synthesis of 2,4‐diaminoquinazolines and 2‐amino‐4‐iminoquinazolines from 2‐aminobenzonitriles and carbodiimides is described. This SnCl4 mediated reaction exhibits substrate driven switchable selectivity in product formation based on the substituents of the carbodiimides used. Aryl and primary alkyl‐substituted carbodiimides predominantly give 2‐amino‐4‐iminoquinazolines, while secondary or tertiary alkyl and benzyl‐substituted carbodiimides yield 2,4‐diaminoquinazolines. Products were also transformed into its oxo‐analogues 2‐aminoquinazolin‐4(3H)‐ones through hydrolysis and into highly fused pentacyclic derivatives through Ru(II)‐catalyzed C─H/N─H annulation reaction with diphenylacetylene.
Engineering of Peptide‐Inserted Base Editors with Enhanced Accuracy and Security
Authors: Chen Qi , Sun Yangning , Yao Jia , Lu Yingfan , Qiu Ruikang , Zhou Fuling , Deng Zixin , Sun Yuhui 
Published: February 2025

AbstractBase editors are effective tools for introducing base conversions without double‐strand breaks, showing broad applications in biotechnological and clinical areas. However, their non‐negligible bystander mutations and off‐target effects have raised extensive safety concerns. To address these issues, a novel method is developed by inserting specific peptide fragments into the substrate binding pocket of deaminases in base editors to modify these outcomes. It is validated that the composition and position of the inserted peptide can significantly impact the performance of A3A‐based cytosine base editor and TadA‐8e‐based adenine base editor, leading to improved editing activity and precision in human HEK293T cells. Importantly, the TadA‐8e variant with DPLVLRRRQ peptide inserted behind S116 residue showed a strong motif preference of Y4A5N6, which can accurately edit the A5 base in targeted protospacer with minimized bystander and off‐target effects in DNA and RNA‐level. By summarizing the regularity during engineering, a set of systematic procedures is established, which can potentially be used to modify other types of base editors and make them more accurate and secure. In addition, the peptide insertion strategy is also proven to be compatible with traditional amino acid changes which have been reported, exhibiting excellent compatibility.
Ferromagnetic Boundary States in the Hydrogenated Graphene/Nickel Moiré Superlattice
Authors: Song Yang , Du Shixuan , Liu Feng , Zhang Lizhi 
Published: February 2025

AbstractZigzag graphene nanoribbons (ZGNRs) exhibit spin‐polarized edge states, which are key elements for designing graphene‐based spintronics devices. The intrinsic ZGNRs have an antiferromagnetic ground state, which can be modified by edge engineering and external field. Here, this work proposes an avenue to realize the zigzag graphene/graphane nanoribbon superlattice (ZGNR‐SL) on Ni(100) by selective hydrogenation of the 1D moiré patterns, based on the first‐principles calculations. The growth mechanism of the ZGNR‐SL is revealed having two steps: first, hydrogen atoms intercalate at the interface of graphene/Ni and form H ribbons in the apex regions of the 1D moiré pattern; second, the intercalated hydrogen ribbons serve as a template for the directed hydrogen adsorption on both sides of the graphene over the hydrogen ribbons. Interestingly, ZGNR‐SL on Ni(100) surface exhibit ferromagnetic boundary states, which may be exploited in potential spintronics device applications.
In Situ Nitric Oxide Generating Nano‐Bioactive Glass‐Based Coatings and Its Therapeutic Ion Release toward Attenuating Implant‐Associated Fibrosis and Infection
Authors: Moses Joseph Christakiran , Sapkota Aasma , Wu Yi , Martinez Isabel , Handa Hitesh , Brisbois Elizabeth J. 
Published: February 2025

AbstractNitric oxide (NO) is a potent gasotransmitter that exhibits a pleiotropic effect in regulating homeostasis and pathophysiology. Though it is a versatile biomaterial, silicone‐based devices are still challenged by implant‐associated infections and fibrous capsule formation complications. Here, a NO‐generating (NOgen) interface is developed from copper or strontium‐doped mesoporous bioactive glass‐based coating on silicone substrates to facilitate metal‐ion catalysis of endogenous S‐nitrosothiols. The copper or strontium‐based interfaces can generate physiologically relevant NO levels, which have bactericidal and antithrombotic effects to combat implant‐associated early onsite infection and thrombosis. The NO generated in tandem with the low therapeutic release of strontium ions from the NOgen interface regulates cellular fate pertaining to fibroblasts, macrophages, and endothelial cells. Strontium suppresses the collagen expression and migration of activated fibroblasts while favoring M2 phenotype bias in macrophages. Differential NO flux observed over time from NOgen interfaces helps switch macrophages from proinflammatory M1 phenotype to M2 anti‐inflammatory phenotype. Moreover, the synergistic effect of leachate and NO generated by the silicone substrate demonstrates a proangiogenic effect by aiding endothelial network maturation in vitro. Thus, the multifunctional features of the developed strontium‐doped bioactive glass‐based coating hold promise in regulating local immune‐micromilieu and attenuating implant‐associated fibrosis of silicone‐based implantable devices.
Identification of Protein Content of Immature Canine Oocytes
Authors: Cerbón‐Gutierrez José Luis , Balcázar‐Sánchez Juan Alberto , Guerrero‐Netro Hilda Morayma 
Published: February 2025

ABSTRACTThe use of biotechnologies in wild canids, such as in vitro oocyte maturation (IVM) and fertilization (IVF), has received little attention. One of the main reasons is the difficulty in finding a relevant in vitro model, and domestic dogs (Canis lupus familiaris) may be a viable alternative. In vitro oocyte maturation in dogs is not well established, but canine oocytes can spontaneously restart meiosis through adaptations of bovine IVM protocols resulting in maturation rates of 10%–39%. To continue with the development of IVM and IVF protocols, the use of analytical techniques is necessary, but they require a minimum amount of protein. Oocyte protein content has been previously reported in different species. Unfortunately, the protein content in the canine oocyte remains unknown. In the present study, two different Bradford‐based assays were used to determine the protein content in the immature oocyte of the domestic canines. To determine the protein content, 1500 immature oocytes were recovered from the ovaries of bitches and analyzed with Pierce 660 nm Protein Assay and Quant‐iT Protein Assay Kit. Oocyte protein content average with Pierce 660 nm assay was 0.222 µg/oocyte, while for the Quant‐iT Protein Assay Kit, the average was 0.205 µg/oocyte. Knowledge of the amount of protein contained in the canine immature oocyte will favour the design and development of experimental work with greater certainty and efficiency, as well as making efficient use of the samples, which will favour progress in the knowledge of the IVM of canine oocytes.
Does Mammography Density Change the Response to Neoadjuvant Chemotherapy and Predict a Pathological Complete Response Rate?
Authors: Kumar Upander , Mishra Anand Kumar , Singh Kul Ranjan , Parihar Anit , Raja Nancy , Raam Mithun , Rahalkar Ashwinee , Ramakant Pooja 
Published: February 2025

ABSTRACTBackgroundPathological complete response (PCR) is the surrogate marker of the outcome of a breast cancer patient. Breast cancer (BC) patients have variable responses to neoadjuvant chemotherapy (NACT). The effect of chemotherapy on mammographic density (MD) is unclear in the literature. Also, MD and PCR correlation is not extensively studied. The aim of the present study is to find MD's potential as a PCR predictor in a resource‐constrained setting.MethodsThe study included all patients of BC‐related surgery from January 2018 to June 2021 with follow‐up till June 2023. MD was classified by the American College of Radiology (ACR) (classes A–D) based on breast composition. The chi‐square test and logistic regression analysis were used to calculate p‐values.ResultsOut of 557 patients, 554 were female with a mean age 46.8 years (premenopausal 54.5%). ACR grades of MD A, B, C, and D were 18.1% (n = 101), 56% (n = 312), 21.5% (n = 120), and 4.3% (n = 24), respectively. The odds of having PCR with MD B, C, and D were 0.51, 0.04, and 0.03, respectively, with respect to MD A. There was a significant inverse association of PCR and Ki‐67 with MD on multivariate analysis. HER2 positive, TNBC, Ki 67 > 15%, and grade 3 had significantly high PCR.ConclusionMD had an inverse correlation with PCR and Ki‐67. Low MD, HER2 positive, TNBC, high Ki‐67 subtypes, and grade 3 were good predictors for PCR.
Long‐Term Outcomes of Sigmoid, Rectosigmoid, and Rectal Cancers: A Matched Analysis
Authors: Benlice Cigdem , Elhan Atilla Halil , Gorgun Emre , Kuzu Mehmet Ayhan 
Published: February 2025

ABSTRACTBackgroundTo determine a population‐based comparative matched overall survival analysis for patients undergoing curative resection for sigmoid, rectosigmoid, and rectal cancers stage by stage.MethodsPatients who underwent curative surgery for nonmetastatic adenocarcinoma of the sigmoid, rectosigmoid, and rectum between 2000 and 2020 were identified using the US SEER cancer registry data. Each anatomical subsegment was matched in a 1:1 ratio based on age, sex, time of surgery, grade of differentiation, and histopathological stage. Multivariate (MV) Cox regression analysis was conducted.ResultsA total of 19,607 patients fulfilled the criteria per group. Whereas chemotherapy rates were comparable among groups, radiotherapy rates were significantly higher in the rectum. Compared to the initial time period (2000–2005), there was a significant improvement in 3‐ and 5‐year overall survival rates for each stage in the time period of 2016–2020. During the study period, a 10% improvement was observed for Stage‐2 and Stage‐3 patients for each site (p < 0.05). MV analysis showed that sex (p < 0.001), primary cancer site (p < 0.001), year category (p < 0.001), age (p < 0.001), stage (p < 0.001), degree of differentiation (p < 0.001), and CTx status (p < 0.001) were independently associated with overall survival.ConclusionThis large population‐based, comprehensive registry study demonstrates significant survival differences among sigmoid, rectosigmoid, and rectal cancers. Further studies defining distinct landmarks between rectal and colon cancers may improve treatment approaches, cancer care, and survival.
Knowledge, Uncertainty, and Ignorance Around Health Risks
Authors: Burton-Jeangros Claudine 
Published: February 2025

Abstract
This chapter examines how continuously extending evidence about risks is produced, circulated, and received in society. The capacity to calculate odds has been socially valued since it offers a framework promoting social order and a contract for living together which would seem a priori favorable to all. However, across a range of health risks, including lifestyles, genetic or cancer screening, exposure to environmental threats, and infectious diseases, the authority of formal risk knowledge is recurrently challenged. In addition to the difficulties reported by people who have to make decisions based on predicted risks, the logic of risk continues to expand the scope of possible actions. I consider that as a consequence, opportunities for conflicts across contrasted views about the best way to protect health increase. In addition, social influences affecting the production and circulation of knowledge, or its manipulation to serve specific interests, reveal that multiple filters take place between risk knowledge and measures advocated to protect individual and public health. With this chapter, I intend to show how, in recent decades, the proliferation of risk has contributed to transforming the relationships between science and society.
Anxiety, Fear, and Panic: The Role of Emotions in Prevention
Authors: Burton-Jeangros Claudine 
Published: February 2025

Abstract
In risk management, anxiety, fear, and panic are associated with disorder and considered to bias decisions. Indeed, the idea of risk emphasizes control over adverse situations; it has thus been expected to eliminate fear in human activities. However, emotions, beyond their psychological expression, are inherent to risk experiences. Against the prevailing cultural background of pessimism and anxiety, I claim that they shape views on what ought to be done to avert danger across society. This chapter thus discusses the ambivalent role of fear or panic in the prevention of health risks since efforts to discard such emotions with preventive measures are constantly counterbalanced through their amplification by professionals, policy-makers, and the media. Overall, I discuss how recurrent references to risk, rather than alleviating fear, contribute to unsettle everyday experiences of health.
Introduction to Unifying Sustainability Information
Authors: Aebi Carol 
Published: February 2025

Abstract
This chapter presents introduces a new unifying framework for harmonizing social sustainability data across various sectors, including businesses, governments, and social organizations. This chapter introduces a Conceptual Model for a Stigmergic Information System Network designed to effectively measure and support decision-making to manage social impacts. This model integrates systems thinking, dynamics, and stigmergic systems into a framework that operates across micro to macro scales within dynamic social environments. The model was developed through a doctoral research project applying the Inductive Top-Down Theory Building Approach. This research synthesizes existing literature to develop a flexible and resilient model that adapts to technological and social changes. This chapter describes that the book chapters are organized in a format that reflects the conceptual theory-building process.
Unveiling Challenges in Migrating from 5G to 6G: Insights from Wireless Communication Networks
Authors: Farhat Shaista , Shaikh Sumaiya , Jabbar M. A. , Farhat Shagufta 
Published: February 2025

Abstract
The evolution from 5G to 6G wireless communication networks signals the dawn of a transformative era in technological innovation and connectivity. However, this evolution is fraught with multifaceted challenges that extend beyond mere technological upgrades. This paper unveils the hidden obstacles that must be navigated to achieve a seamless migration to 6G. Key challenges include the integration of advanced technologies such as terahertz communication, quantum computing, and artificial intelligence, which necessitate unprecedented levels of research and development. Additionally, the requirement for ultra-low latency, massive connectivity, and enhanced security introduces complexities in network architecture and design. Regulatory and standardization issues, alongside the need for substantial infrastructural investments, further complicate the migration process. Socio-economic factors, including digital divide concerns and the environmental impact of new infrastructure, also play critical roles. By discussing these challenges, this paper provides a comprehensive understanding of the prerequisites for successful 6G deployment, laying the groundwork for future research and policy development aimed at overcoming these obstacles.
Research on Cybersecurity System of Scientific Research Institutions Based on National Cybersecurity Classified Protection 2.0: Take the Chinese Academy of Agricultural Sciences as an Example
Authors: Wang Dan , Tu Yuanyuan , Sun Yang , Xie Hui , Wang Jian , Wan Feng , Wang Yanjun 
Published: February 2025

Abstract
In recent years, various agricultural research institutions in China have begun to increase the investment in informatization construction, so informatization brings great convenience to scientific research and management, but corresponding cybersecurity issues have become more and more important. Relying on the cybersecurity classified protection work, in-depth analysis of each weak link in the cyber system construction of agricultural scientific research institutions, to improve the information system security and avoid information security incidents has been placed in the prominent position of agricultural research institutions.[Method/Process] This article discusses the content of strengthening the cybersecurity management of agricultural scientific research institutions based on National Cybersecurity Classified Protection 2.0. First of all, this article introduces the importance of cybersecurity classified protection. Secondly, the difference between National Cybersecurity Classified Protection 2.0 standard and National Cybersecurity Classified Protection 1.0 standard is analyzed. Thirdly, the system of cybersecurity management and the content of cybersecurity management technology of Chinese Academy of Agricultural Sciences were analyzed in detail. Finally, it discusses and summarizes the effective strategies to strengthen the information security construction of agricultural research institutions. [Results/Conclusions] Taking the Chinese Academy of Agricultural Sciences as an example, this paper discusses its related practices in detail, hope to provide reference for agricultural research institutions to carry out cybersecurity level protection and security construction.
Analysis of Spatial-Temporal Evolution of Water Surface Area in DaSuGan Lake Based on Multi-source Satellite Images and Computer Vision Technology
Authors: Shang Liping , Du Yu′e , Liu Baokang 
Published: February 2025

Abstract
Lakes are sensitive indicators of climate change, and obtaining the information of lake water quickly and accurately is of great significance for regional climate change research, the protection and governance of ecological environment. This article is based on multi-source satellite images such as Landsat and GF-6, and uses the method of empirical threshold and single band threshold and water index and other methods to extract the water area of DaSuGan lake. Based on the accuracy evaluation results, the optimal water identification model is selected, and the spatial-temporal evolution law of the water area of DaSuGan lake is analyzed from 1991 to 2020. The results show that: