bluuebunny/crossref_metadata_2025_split huggingface dataset:
Searching for ringdown higher modes with a numerical relativity-informed post-merger model
Authors: Gennari Vasco , Carullo Gregorio , Del Pozzo Walter 
Published: March 2024

AbstractRobust measurements of multiple black hole vibrational modes provide a unique opportunity to characterise gravity in extreme curvature and dynamical regimes, to better investigate the nature of compact objects and search for signs of new physics. We use a numerically-tuned quasicircular non-precessing ringdown model, , and the analysis infrastructure to perform a time-domain spectroscopic analysis of the third catalog of transient gravitational-wave signals, GWTC-3, searching for higher angular modes. The model effectively includes non-linearities in the early post-merger signal portion, and carries information about the progenitors parameters through time-dependent excitation amplitudes of the black hole quasinormal modes. Such a strategy allows us to accurately model the full post-merger emission, recovering higher signal-to-noise ratios compared to templates based on more agnostic superpositions of damped-sinusoids. We find weak evidence for the presence of$$(l,m)=(3,3)$$(l,m)=(3,3)[$$(l,m)=(2,1)$$(l,m)=(2,1)] mode in several events, with the largest Bayes factor in favour of this mode being$${\mathcal {B}} \simeq 2.6$$B≃2.6[$${\mathcal {B}} \simeq 1.2$$B≃1.2] within the support of the peak time distribution. For GW190521, we observe$$ {\mathcal {B}} \simeq 5.1$$B≃5.1, but only for times outside the peak time support reconstructed using the highly accurate model, indicating significant systematics affecting such putative detection. Allowing for deviations from general relativity under the assumption of the presence of two modes, we find tentative support for the Kerr “final state conjecture”. Our work showcases a systematic methodology to robustly identify and characterise higher angular modes in ringdown-only signals, highlighting the significant impact of modelling assumptions and peak time uncertainty on spectroscopic measurements, at current signal-to-noise ratios.
Plasma Proteomic Signature Predicts Myeloid Neoplasm Risk
Authors: Tran Duc , Beeler J. Scott , Liu Jie , Wiley Brian , Chan Irenaeus C.C. , Xin Zilan , Kramer Michael H. , Batchi-Bouyou Armel L. , Zong Xiaoyu , Walter Matthew J. , Petrone Giulia E.M. , Chlamydas Sarantis , Ferraro Francesca , Oh Stephen T. , Link Daniel C. , Busby Ben , Cao Yin , Bolton Kelly L. 
Published: March 2024

Abstract

Purpose:
Clonal hematopoiesis (CH) is thought to be the origin of myeloid neoplasms (MN). Yet, our understanding of the mechanisms driving CH progression to MN and clinical risk prediction of MN remains limited. The human proteome reflects complex interactions between genetic and epigenetic regulation of biological systems. We hypothesized that the plasma proteome might predict MN risk and inform our understanding of the mechanisms promoting MN development.

Experimental Design:
We jointly characterized CH and plasma proteomic profiles of 46,237 individuals in the UK Biobank at baseline study entry. During 500,036 person-years of follow-up, 115 individuals developed MN. Cox proportional hazard regression was used to test for an association between plasma protein levels and MN risk.

Results:
We identified 115 proteins associated with MN risk, of which 30% (N = 34) were also associated with CH. These were enriched for known regulators of the innate and adaptive immune system. Plasma proteomics improved the prediction of MN risk (AUC = 0.85; P = 5×10–9) beyond clinical factors and CH (AUC = 0.80). In an independent group (N = 381,485), we used inherited polygenic risk scores (PRS) for plasma protein levels to validate the relevance of these proteins toMNdevelopment. PRS analyses suggest that most MN-associated proteins we identified are not directly causally linked toMN risk, but rather represent downstream markers of pathways regulating the progression of CH to MN.

Conclusions:
These data highlight the role of immune cell regulation in the progression of CH to MN and the promise of leveraging multi-omic characterization of CH to improveMN risk stratification.
See related commentary by Bhalgat and Taylor, p. 3095
Patient-Derived Tumor Xenograft Study with CDK4/6 Inhibitor Plus AKT Inhibitor for the Management of Metastatic Castration-Resistant Prostate Cancer
Authors: Kase Adam M. , Gleba Justyna , Miller James L. , Miller Erin , Petit Joachim , Barrett Michael T. , Zhou Yumei , Parent Ephraim E. , Cai Hancheng , Knight Joshua A. , Orme Jacob , Reynolds Jordan , Durham William F. , Metz Thomas M. , Meurice Nathalie , Edenfield Brandy , Alasonyalilar Demirer Aylin , Bilgili Ahmet , Hickman Peyton G. , Pawlush Matthew L. , Marlow Laura , Wickland Daniel P. , Tan Winston , Copland John A. 
Published: March 2024

Abstract
Metastatic castration-resistant prostate cancer (mCRPC) is an aggressive malignancy with poor outcomes. To investigate novel therapeutic strategies, we characterized three new metastatic prostate cancer patient derived-tumor xenograft (PDTX) models and developed 3D spheroids from each to investigate molecular targeted therapy combinations including CDK4/6 inhibitors (CDK4/6i) with AKT inhibitors (ATKi).
Metastatic prostate cancer tissue was collected and three PDTX models were established and characterized using whole-exome sequencing. PDTX 3D spheroids were developed from these three PDTXs to show resistance patterns and test novel molecular-targeted therapies. CDK4/6i's were combined with AKTi's to assess synergistic antitumor response to prove our hypothesis that blockade of AKT overcomes drug resistance to CDK4/6i. This combination was evaluated in PDTX three-dimensional (3D) spheroids and in vivo experiments with responses measured by tumor volumes, PSA, and Ga-68 PSMA-11 PET-CT imaging.
We demonstrated CDK4/6i's with AKTi's possess synergistic antitumor activity in three mCRPC PDTX models. These models have multiple unique pathogenic and deleterious genomic alterations with resistance to single-agent CDK4/6i's. Despite this, combination therapy with AKTi's was able to overcome resistance mechanisms. The IHC and Western blot analysis confirmed on target effects, whereas tumor volume, serum PSA ELISA, and radionuclide imaging demonstrated response to therapy with statistically significant SUV differences seen with Ga-68 PSMA-11 PET-CT.
These preclinical data demonstrating antitumor synergy by overcoming single-agent CDK 4/6i as well as AKTi drug resistance provide the rational for a clinical trial combining a CDK4/6i with an AKTi in patients with mCRPC whose tumor expresses wild-type retinoblastoma 1.
Political Natural Law and Human Dignity: an Empiricist Perspective
Authors: Zhang Qianfan , Wei Xiaoyang 
Published: March 2024

Abstract
This article argues that observing natural laws is crucial for preserving peace in nations across the world. Traditional natural law theories are, however, flawed and outdated. To truly modernize natural law, we propose a new concept, “political natural law” (PNL), which has the capacity of curing these flaws. We then substantiate the PNL s from the result of analyzing the institutional causes of civil wars since 1800, and link them to human dignity. Drawing partly on the Confucian scholarship on natural law and human dignity, we argue that the mutual respect of human dignity is essential to building and sustaining global peace.
Similarities and Differences between Religious Communities in Addressing Climate Change
Authors: Albareda-Tiana Silvia , Fernández-Morilla Mónica , Guitián Gregorio , Pérez-Madrid Francisca , Hernández Serret Joan , Chuvieco Emilio 
Published: March 2024

Abstract
This study explores: a) what is being done by religions present in Catalonia (Spain) to address climate change; b) what the worldviews of the different religions are with regard to climate change, and, c) if commonalities exist between religions, which elements they have in common when addressing climate change. We focus on SDG 12 (sustainable consumption) and 13 (climate action), two of the 17 global goals that represent an urgent call for action. We employ a qualitative phenomenological methodology involving discussion groups of fourteen different religions present in Catalonia. The results show that the religions implement good practices that contribute to climate action, and all of them have laid down principles to take care of the planet. All groups hold that a change in values is required to address the climate crisis, and translate it into action. Moreover, a clear intention to establish interfaith partnerships for climate action is observed.
“Give Us This Day Our Daily Bread”
Authors: Amarkwei Charles 
Published: March 2024

Abstract
The goal of this paper is to present a Christian mission of hunger and poverty alleviation through a life in communion with the trinity and in the context of the Ga celebration of homowo in Ghana. It is in the hope of the renewal of all things at the end of the world. It is to appreciate the essence of homowo in order to appropriate it for a Christian mission. The paper seeks to achieve this goal of mission by connecting the hunger and poverty alleviation and life-giving essence as well as the sense of unity embedded in the homowo feast to the mission of the triune God in the cosmos and with the “give us this day our daily bread” statement of Jesus Christ. Although the Kpelelogical method seems to be easily understood because it is mutually critical and connects seamlessly with the praxis of Christianity among Ga Christians, it has previously not been adopted as a theological method, as it is in this article. It is the paradoxical Ga Christian articulation of the Christian faith whereby the Christian faith is enlightened by the Kpele homowo and yet transforms the Kpele homowo after rejecting it. At the end of the engagement, Jesus in the homowo celebration is seen as the Okpelejen Wulormor Homoyiwolor ker Naanowalahalor (the cosmic priest, king, prophet who jeers at hunger, and giver of eternal life).
Tropical Atmospheric Intraseasonal Oscillations Leading to Sea Level Extremes in Coastal Indonesia during Recent Decades
Authors: Kamp William , Han Weiqing , Zhang Lei , Kido Shoichiro , McCreary Julian P. 
Published: March 2024

Abstract
Coastal flooding induced by sea surface high extreme (HEX) events is an increasing risk to human society and infrastructure as both urban growth in coastal areas and anthropogenic sea level rise continue, especially for island nations like Indonesia. This paper investigates the role of atmospheric intraseasonal oscillations (ISOs), which are dominated by the Madden–Julian oscillation (MJO), in forcing HEXs on the coasts of Indonesia bordering the Indian Ocean. We use satellite altimetry data from 1993 to 2021 and tide gauge observations to detect HEXs, and modeling experiments using both the Regional Ocean Modeling System and a Bayesian dynamic linear model to understand the forcing and processes. We find that HEXs exhibit strong seasonality, with most events occurring during boreal winter (December–February) and spring (March–May) that are dominated by seasonal-to-decadal and intraseasonal variability respectively. In 32% of the 56 HEX events detected, the amplitude of ISO-induced sea level anomalies (SLAs) exceeds that of seasonal-to-decadal SLAs. Surface wind stress associated with atmospheric ISOs is the major forcing for intraseasonal SLAs, and both the remote westerly wind stress from the Indian Ocean equator and northwesterly longshore wind stress at the Indonesian coasts play important roles in driving the HEXs. The MJO is the dominant cause of ISO-dominated HEXs and its impact shows strong seasonal differences. Spring MJOs are associated with stronger convective anomalies over the eastern Indian Ocean equator that drive stronger zonal winds across the equatorial basin that lead to more HEX events compared to winter MJOs when the convection is shifted southward.
Intervening Effect of Maladaptive Personality on the Relationship Between Defense Styles and Psychiatric Symptoms Among Prisoners
Authors: Ishfaq Nimrah , Kamal Anila 
Published: March 2024

Background: Prison settings are stress-inducing environments that make individuals more vulnerable to psychopathology. Defense styles and personality traits have long been associated with psychopathology. The current study aimed to explain the intervening role of maladaptive personality domains on the relationship between defense styles and psychiatric symptoms among male convicts imprisoned in nine Central Jails of Punjab, Pakistan. Method: Through cross-sectional design, data was collected through purposive sampling. 509 respondents (who were serving their sentence for the crime committed) with a Mean age of 35 years (10.21) provided data on self-reported translated versions of the Cross-Cutting Symptoms Measure, Personality Inventory for DSM 5 - Adult version (Short Form), and Defense Style Questionnaire. Results: Findings of the mediation analysis showed that negative affectivity, disinhibition, and psychoticism mediated the relationship between immature defense style and psychiatric symptoms whereas moderation analysis showed a significant interactional effect of antagonism with mature and neurotic defense style on psychiatric symptoms exclusively. Confusions: Findings have highlighted that defense styles and certain personality domains intervene to have a combined indirect effect on psychiatric symptoms. The study also contributes to the literature by specifying the interactional effect of antagonism and mature defense style on predicting psychiatric symptoms.
Correlates of early breastfeeding cessation and breastmilk expression in Uganda: a case–control study
Authors: Du Yu , Onyango-Makumbi Carolyn , Walia Bhavneet , Owor Maxie , Musoke Phillipa , Owora Arthur H. 
Published: March 2024

Objective To identify the correlates of early breastfeeding (BF) cessation and breastmilk expression (BE) among mothers 12 months after childbirth. Methods We used a case-control study design to compare characteristics between mothers who stopped BF and expressed breastmilk 12 months after childbirth in Uganda. BF practices were determined in 12-month follow-up interviews using an adapted World Health Organization infant feeding questionnaire. Univariate and bivariate logistic regression models identified correlates of early BF cessation and BE as distinct but related outcomes. Results The odds of early BF cessation were higher among mothers who expressed breastmilk irrespective of maternal age (adjusted odds ratio: 2.82; 95% confidence interval: 1.39, 5.68). Mothers who stopped BF and did not express breastmilk were more likely to be older than those who continued BF and did not express breastmilk during the first 12 postpartum months. Conclusion Mothers living with human immunodeficiency virus infection have disproportionately high odds of early BF cessation that may contribute to disparities in child health outcomes. Promotion of safe BF practices coupled with family and social support could be a viable preventive strategy for attenuating such disparities, especially among young mothers at risk of early BF cessation.
Induction and Characterization of Tetraploids from Astragalus membranaceus (Fisch.) Bge. Seeds
Authors: Zhang Shu-ling , Zhang Xin , Wang Meng , Dong Li-jun , Liu Gui-xia 
Published: March 2024

Background Astragalus membranaceus (Fisch.) Bge., as a Traditional Chinese Medicine, not only has ornamental and medicinal value but also plays a role in the effect of sand fixation. At present, the resources of wild A. membranaceus are exhausted with the deterioration of the ecological environment and the increase in market demand. Moreover, there are no excellent varieties for the artificial cultivation of A. membranaceus to meet the market demand. Objectives To establish a method to create an efficient induction of tetraploids by colchicine technique in A. membranaceus. Materials and Methods The germinating seeds were soaked in different concentrations of colchicine solution and exposure times to induce tetraploids in A. membranaceus, and the induced plants were identified by morphological characteristics comparison and root-tip chromosome determination. The contents of polysaccharides, saponins, and flavonoids and the activity of superoxide dismutase (SOD), peroxidase (POD), and catalase (CAT) were measured in diploid and tetraploid plants. Results The results showed that the highest tetraploid induction ratio of germinating seeds in A. membranaceus is obtained from the 0.2% (w/v) colchicine treatment for 36 h, and the chromosome number of tetraploid seedlings was 2n = 4x = 32. The morphological traits and anatomical structure characteristics of leaves from tetraploid plants exhibited significant differences from the diploid plants. The contents of polysaccharides, saponins, and flavonoids and the activity of SOD, POD, and CAT are also increased in tetraploid plants. Conclusion In summary, our study provided an effective method to induce A. membranaceus polyploidy, which could be used to develop new germplasm innovations for improving the medicinal value of A. membranaceus.
Direct induction onto high-dose long-acting injectable buprenorphine: A case series
Authors: Naren Thileepan , Cook Jon , MacCartney Paul 
Published: March 2024

Introduction This case series reports on five patients with opioid use disorder (OUD) who were commenced directly onto high-dose long-acting injectable buprenorphine (LAIB). Method A retrospective audit and manual review of the electronic medical record at cohealth Innerspace was conducted for patients who had been directly inducted onto high-dose LAIB. Results Five cases were identified on retrospective manual file review. All patients identified were males aged between 33 and 60 years old and were treated with either high-dose Buvidal Weekly and Monthly preparations. No immediate significant adverse effects were noticed and 4 out of 5 remain engaged with treatment. Conclusion This case series shows it is possible to directly induct patients with OUD onto high-dose LAIB preparations without significant side effects or harm to the patient and could be considered a viable option in the treatment of patients with OUD.
Management of symblepharon with Gore-tex as a novel treatment option for ocular chemical burns
Authors: Venugopal Anitha , Gurnani Bharat , Ravindran Meenakshi , Uduman Mohammed Sithiq 
Published: March 2024

Purpose To assess the clinical outcomes of symblepharon release in patients with ocular surface chemical injury using Gore-Tex as a novel treatment option. Methods This was a retrospective analysis of 23 eyes of 22 chemical injury patients done during a period of January 2014 to December 2021 at a tertiary eye care centre in South India. All patients underwent symblepharon lysis along with Gore-Tex application over the sclera with minimum 1 year follow up. The patients were assessed for demographic details, visual acuity, intraocular pressure, anterior and posterior segment details, photographic documentation, preoperative diagnosis, previous surgical details in recurrent cases, surgical procedures, final visual acuity, surgical outcomes, and complications. The clinical outcomes were assessed and outcomes were defined as success, partial success, or failure. Results The median age was 17 years (IQR, 12–39 years). Among them 10 eyes with symblepharon had grade 3 length, 12 eyes grade 3 width and 12 eyes had grade 3 loss of palisades of Vogt. The success was achieved in 52.2% of the patients; partial success in 34.8% and 13.3% had failure. The mean duration of recurrence was 6.75 ± 3.6 months. Failure was noted in young patients with mean age 9.75years and with grade 3c symblepharon. There was no sight threatening complications noted. Conclusion The study showed very good results with Gore-Tex as a novel treatment option for chemical injury patient with symblepharon formation. It can be easily employed to prevent the symblepharon recurrence of various ocular surface disorders.
Increasing primary care capacity and referral efficiency: A case study of a telehealth centre eConsult service in Brazil
Authors: Catapan Soraia de Camargo , Bruckmann Guilherme , Nilson Luana Gabrielle , Caffery Liam J , Kelly Jaimon T. , Calvo Maria Cristina Marino , Boing Antonio Fernando 
Published: March 2024

Introduction eConsults are asynchronous digital communications for primary care professionals to seek timely specialist advice. Potential benefits include increased primary healthcare capacity and referral efficiency. Santa Catarina Telehealth Centre in Brazil has offered eConsults for an increasing number of specialties since 2008. This study described the characteristics of this service, including referral efficiency, sustainability, and satisfaction. Methods Retrospective longitudinal analysis of eConsults activity data from 2015 to 2022 with three domains of the Model for Assessment of Telemedicine Applications used to structure the analysis. Results Characteristics of the application: The total number of eConsults performed in 2015 was 4764, reaching 41,178 in 2022. While 30.3% of eConsults were synchronous in 2015, only asynchronous communication remained from 2021. Clinical effectiveness: eConsults requested to refer patients to specialist care resulting in primary care management remaining above 30% of the total for all specialties from 2019 to 2022, with hematology having the highest percentage (>52%). Organizational aspects: Established workflows with local specialists responding to eConsults (cardiology, endocrinology, hematology and orthopaedics) kept a constant or increasing number of eConsults and maintained the proportion of primary care management from 2019 to 2022, once recovered from COVID-19 and funding restrictions-related reductions. Over 90% of primary care professionals are either satisfied or very satisfied with the eConsult service. Conclusion Over 8 years, 223,734 consultations were conducted, with high satisfaction, demonstrating the substantial potential for increased primary care-sensitive conditions management. Hiring local specialists, fostering integrated care, and enabling sustainable workflows are key to eConsults’ success.
Trends in social inequality in breastfeeding duration in Denmark 2002–2019
Authors: Carlsson Rikke R. , Pommerencke Lis Marie , Pant Sofie W. , Jørgensen Sanne E. , Madsen Katrine R. , Bonnesen Camilla T. , Kierkegaard Lene , Pedersen Trine P. 
Published: March 2024

Aims: The aim of the present study was to analyse trends in full breastfeeding for at least 4 months across socioeconomic position in Denmark over a 17-year-long period from 2002 to 2019 using parental education as the indicator of socioeconomic position. Methods: The study used data on full breastfeeding collected between 2002 and 2019 by community health nurses in the collaboration Child Health Database, n=143,075. Data were linked with five categories of parental education from population registers. Social inequality was calculated as both the relative (odds ratio) and absolute social inequality (slope index of inequality). A trend test was conducted to assess changes in social inequality over time. Results: A social gradient in full breastfeeding was found for the entire study period. The odds ratio for not being fully breastfed for at least 4 months ranged from 3.30 (95% confidence interval 2.83–3.84) to 5.09 (95% confidence interval 4.28–6.06) during the study period for infants of parents with the lowest level of education (primary school) compared with infants of parents with the highest level of education (5+ years of university education). The slope index of inequality was between −38.86 and −48.81 during the entire study period, P=0.80. This indicated that both the relative and absolute social inequality in full breastfeeding to at least 4 months of age was unchanged in the study period from 2002 to 2019. Conclusions: This study showed a persistent relative and absolute social inequality in full breastfeeding for at least 4 months from 2002 to 2019 in Denmark.