bluuebunny/crossref_metadata_2025_split huggingface dataset:
Glymphatic dysfunction and choroid plexus volume increase in older adults with poor sleep quality
Authors: Kikuta Junko , Kamagata Koji , Takabayashi Kaito , Hayakawa Yayoi , Taoka Toshiaki , Saito Yuya , Uchida Wataru , Guo Sen , Yoshida Seina , Yamazaki Keigo , Wada Akihiko , Kaga Hideyoshi , Tamura Yoshifumi , Kawamori Ryuzo , Watada Hirotaka , Aoki Shigeki 
Published: April 2024

Abstract
Objective
This study aimed to explore alterations in diffusion tensor image analysis along the perivascular space (DTI-ALPS) method and choroid plexus volume (CPV), which could be biomarkers of the glymphatic system in older adults with poor sleep quality (PSQ).
Methods
Fifty-two Japanese older adults with Pittsburgh Sleep Quality Index (PSQI) scores > 5 (22 men and 30 women; mean age ± SD = 73.10 ± 5.67 years) and 52 healthy controls (HCs; PSQI score ≤ 5) were included. Diffusion-weighted imaging (DWI) and 3D T1-weighted images were obtained using 3T magnetic resonance imaging. The ALPS index was calculated using preprocessed diffusion-weighted imaging (DWI), and the CPV was calculated using FreeSurfer 6.0. The mean ALPS index was subsequently compared between the PSQ group and HCs by using a general linear model (GLM) adjusted for covariates, including age, sex, years of education, intracranial volume, systolic blood pressure, diastolic blood pressure, hemoglobin A1c, and white matter lesion volume (WMLV). The CPV was also compared between the two groups by using the GLM, adjusting for the same covariates mentioned above. Next, we conducted a partial correlation analysis between the ALPS index and the CPV, Montreal Cognitive Assessment (MoCA), and PSQI scores, adjusting for all the abovementioned covariates.
Results
Compared with HCs, patients in the PSQ group had a significantly lower mean ALPS (p = 0.04, Cohen’s d = − 0.28) and a greater CPV (p = 0.11, Cohen’s d = 0.24). In the PSQ group, the mean ALPS score was significantly negatively correlated with the CPV (r = − 0.35, false discovery rate [FDR]-corrected p = 0.03) but was significantly positively correlated with the MoCA score (r = 0.35, FDR-corrected p = 0.03).
Conclusion
Older adults with PSQ exhibited a decrease in the glymphatic system and an increase in CPV.
Rheological Compatibility of Sulfonated Naphthalene Formaldehyde on Different Mixing Procedures of Activated Slag-based Mixes
Authors: Sengupta Jayashree , Dhang Nirjhar , Deb Arghya 
Published: April 2024

Abstract
This study delves into examining the flow and viscoelastic properties of soda ash and hydrated lime-activated slag mixes with the introduction of sulfonated naphthalene-formaldehyde (SNF) as a superplasticizer. Three different mixing techniques were employed: standard one-part normal-mixing (NM), pre-mixing soda ash in water (PM), and a dry mixture of granulated blast furnace slag (GGBFS) with a NaOH solution (CM). Without SNF, the yield stress followed the order CM < NM < PM. The optimal percentage of SNF varied depending on the mixing technique: 0.75% for NM, 0.5% for PM, and 0.25% for CM. Adding the right amount of SNF reduced the yield stress in all mixing methods. However, it increased the storage modulus, indicating improved structural integrity. None of the samples displayed a distinct low-velocity elastic response (LVER) plateau.
Shared genetic loci between clozapine metabolism and granulocyte counts
Authors: Koch Elise , Parker Nadine , Lock Siobhan K. , Smith Robert L. , Shadrin Alexey A. , Frei Oleksandr , Dale Anders M. , Djurovic Srdjan , Molden Espen , O´Connell Kevin S. , Andreassen Ole A. 
Published: April 2024

Abstract
While clozapine is the most effective antipsychotic drug, its use is limited due to hematological side effects involving reduction of granulocyte counts with potential life-threatening agranulocytosis. It is not yet possible to predict or prevent the risk of agranulocytosis, and the mechanisms are unknown, but likely related to clozapine metabolism. Genome-wide association studies (GWASs) of clozapine metabolism and clozapine-induced agranulocytosis have identified few genetic loci. We used the largest available GWAS summary statistics of clozapine metabolism (clozapine-to-norclozapine ratio) and clozapine-induced agranulocytosis, applying the conditional false discovery rate (condFDR) method to increase power for genetic discovery by conditioning on granulocyte counts variants. To investigate potential causal effects of shared loci, we performed Mendelian Randomization analyses. After conditioning on granulocyte counts, we identified two novel loci associated with clozapine-to-norclozapine ratio. These loci were associated with clozapine metabolism in a validation sample of 392 clozapine-treated individuals. For clozapine-induced agranulocytosis, five loci were identified after conditioning on granulocyte counts. Genetic liability to slow clozapine metabolism (high clozapine-to-norclozapine ratio) showed evidence of a causal effect on reduced neutrophil counts, and genetic liability to low neutrophil counts exhibited weak evidence of a causal effect on clozapine-induced agranulocytosis. Our findings of shared genetic variants associated with clozapine metabolism and granulocyte counts may form the basis for developing prediction models for clozapine-induced agranulocytosis.
Intervention of IT in Rog Nidan Evum Vikriti Vigyan - An Explorative Review
Authors: Nimisha Mishra  , Prof. Satya Deo Pandey  
Published: April 2024

Introduction: Going by the trend, the Indian traditional medicine system Ayurveda is observing a paradigm shift in its growth, and in the era of technology AI (Artificial Intelligence) is one of the main factors behind it. Be it the discovery of new medicines, implementation of a new drug discovery model, getting its global acceptance through patents, or the delivery of the final product through AI equipped supply chain model system, the intervention of technology cannot be ruled out. Methodology: The literature survey was done through Google Scholar database, PubMed, and Web of Science. The dig out information about the use of IT in Medical fields and, use of technology in Ayurveda were screened for relevant studies synthesis. Result: At last, we have sorted out the areas of Rog-Nidan that need to be taken care of from a research point of view with the help of information technology. Discussion: In this research paper, an effort has been made to review the areas where technology can play its role, especially in Rog-Nidan. Additionally, the approaches that are being used in Ayurveda where it is being presented as wellness therapy and preventive care have been studied along with identifying the gaps that can be addressed with efficient use of IT-based technologies.
Concept of Deshaviparyaya w.s.r. to Migration - A Literary Review
Authors: Gouri M. Wariyar  , Arhanth Kumar K  , Vidyalakshmi K  
Published: April 2024

Desha (geographical distribution) is one of the important principles linked with health of individual. The characteristics of the Desha impart certain physical, physiological, psychological attributes in inhabitants. There is another term Deshaviparyaya which is not much understood. This factor is one main cause for many diseases prevailing nowadays. A comprehensive exploration can be done between Deshaviparyaya and migration. Through a multidisciplinary lens, this work aims to provide insights into complex interplay between geographical disorientation and health effects on people’s health. Aims & Objectives: Literary review on basic concepts of Desha & Satmya (Habituation) & understanding concepts of Deshaviparyaya in view of migration. Materials & Methods: Ayurvedic literatures containing all details about Desha, Satmya & Deshaviparyaya were studied and literary material was critically reviewed. Discussion: Effect of migration and on sleep, integumentary system and generation of stress has been discussed with its Ayurvedic treatment. Conclusion: Migration has impact on different systems of human body. This article can be hypothesized that Desha & Satmya should be considered for successful administration of therapeutics.
Evaluating the Digital Health Experience for Patients in Primary Care: Mixed Methods Study
Authors: Choy Melinda Ada , O'Brien Kathleen , Barnes Katelyn , Sturgiss Elizabeth Ann , Rieger Elizabeth , Douglas Kirsty 
Published: April 2024

Background
The digital health divide for socioeconomic disadvantage describes a pattern in which patients considered socioeconomically disadvantaged, who are already marginalized through reduced access to face-to-face health care, are additionally hindered through less access to patient-initiated digital health. A comprehensive understanding of how patients with socioeconomic disadvantage access and experience digital health is essential for improving the digital health divide. Primary care patients, especially those with chronic disease, have experience of the stages of initial help seeking and self-management of their health, which renders them a key demographic for research on patient-initiated digital health access.

Objective
This study aims to provide comprehensive primary mixed methods data on the patient experience of barriers to digital health access, with a focus on the digital health divide.

Methods
We applied an exploratory mixed methods design to ensure that our survey was primarily shaped by the experiences of our interviewees. First, we qualitatively explored the experience of digital health for 19 patients with socioeconomic disadvantage and chronic disease and second, we quantitatively measured some of these findings by designing and administering a survey to 487 Australian general practice patients from 24 general practices.

Results
In our qualitative first phase, the key barriers found to accessing digital health included (1) strong patient preference for human-based health services; (2) low trust in digital health services; (3) high financial costs of necessary tools, maintenance, and repairs; (4) poor publicly available internet access options; (5) reduced capacity to engage due to increased life pressures; and (6) low self-efficacy and confidence in using digital health. In our quantitative second phase, 31% (151/487) of the survey participants were found to have never used a form of digital health, while 10.7% (52/487) were low- to medium-frequency users and 48.5% (236/487) were high-frequency users. High-frequency users were more likely to be interested in digital health and had higher self-efficacy. Low-frequency users were more likely to report difficulty affording the financial costs needed for digital access.

Conclusions
While general digital interest, financial cost, and digital health literacy and empowerment are clear factors in digital health access in a broad primary care population, the digital health divide is also facilitated in part by a stepped series of complex and cumulative barriers. Genuinely improving digital health access for 1 cohort or even 1 person requires a series of multiple different interventions tailored to specific sequential barriers. Within primary care, patient-centered care that continues to recognize the complex individual needs of, and barriers facing, each patient should be part of addressing the digital health divide.
Preference-Based Implementation of Video Consultations in Urban and Rural Regions in Outpatient Care in Germany: Protocol for a Mixed Methods Study
Authors: Kleinschmidt Lara , Walendzik Anke , Wasem Jürgen , Höfer Klemens , Nauendorf Beatrice , Brittner Matthias , Brandenburg Paul , Aeustergerling André , Schneider Udo , Wadeck Anja , Sehlen Stephanie , Liersch Sebastian , Schwarze Katharina , Schwenke Carsten , Hüer Theresa 
Published: April 2024

Background
Particularly in rural regions, factors such as lower physician density and long travel distances complicate adequate outpatient care. However, urban regions can also be affected by deficits in care, for example, long waiting times. One model of care intending to improve the situation is the implementation of video consultations. The study protocol presents the methodology of the research project titled “Preference-based implementation of the video consultation in urban and rural regions” funded by the German Federal Joint Committee (funding number 01VSF20011).

Objective
This study aims to identify existing barriers to the use of video consultation and the preferences of insured individuals and physicians as well as psychotherapists in order to optimize its design and thus increase acceptance and use of video consultations in urban and rural regions.

Methods
Built on a mixed methods approach, this study first assesses the status quo of video consultation use through claims data analysis and carries out a systematic literature review on barriers and promoting factors for the use of video consultations. Based on this preliminary work, focus groups are conducted in order to prepare surveys with insureds as well as physicians and psychotherapists in the second study phase. The central element of the survey is the implementation of discrete choice experiments to elicit relevant preferences of (potential) user groups and service providers. The summarized findings are discussed in a stakeholder workshop and translated into health policy recommendations.

Results
The methodological approach used in this study is the focus of this paper. The study is still ongoing and will continue until March 2024. The first study phase has already been completed, in which preliminary work has been done on potential applications and hurdles for the use of video consultations. Currently, the survey is being conducted and analyses are being prepared.

Conclusions
This study is intended to develop a targeted strategy for health policy makers based on actual preferences and perceived obstacles to the use of video consultations. The results of this study will contribute to further user-oriented development of the implementation of video consultations in German statutory health insurance. Furthermore, the iterative and mixed methods approach used in this study protocol is also suitable for a variety of other research projects.

International Registered Report Identifier (IRRID)
DERR1-10.2196/50932
Association Between Prosuicide Website Searches Through Google and Suicide Death in the United States From 2010 to 2021: Lagged Time-Series Analysis
Authors: Kelsall Nora Clancy , Gimbrone Catherine , Olfson Mark , Gould Madelyn S , Shaman Jeffrey , Keyes Katherine 
Published: April 2024

Background
The rate of suicide death has been increasing, making understanding risk factors of growing importance. While exposure to explicit suicide-related media, such as description of means in news reports or sensationalized fictional portrayal, is known to increase population suicide rates, it is not known whether prosuicide website forums, which often promote or facilitate information about fatal suicide means, are related to change in suicide deaths overall or by specific means.

Objective
This study aimed to estimate the association of the frequency of Google searches of known prosuicide web forums and content with death by suicide over time in the United States, by age, sex, and means of death.

Methods
National monthly Google search data for names of common prosuicide websites between January 2010 and December 2021 were extracted from Google Health Trends API (application programming interface). Suicide deaths were identified using the CDC (Centers for Disease Control and Prevention) National Vital Statistics System (NVSS), and 3 primary means of death were identified (poisoning, suffocation, and firearm). Distributed lag nonlinear models (DLNMs) were then used to estimate the lagged association between the number of Google searches on suicide mortality, stratified by age, sex, and means, and adjusted for month. Sensitivity analyses, including using autoregressive integrated moving average (ARIMA) modeling approaches, were also conducted.

Results
Months in the United States in which search rates for prosuicide websites increased had more documented deaths by intentional poisoning and suffocation among both adolescents and adults. For example, the risk of poisoning suicide among youth and young adults (age 10-24 years) was 1.79 (95% CI 1.06-3.03) times higher in months with 22 searches per 10 million as compared to 0 searches. The risk of poisoning suicide among adults aged 25-64 was 1.10 (95% CI 1.03-1.16) times higher 1 month after searches reached 9 per 10 million compared with 0 searches. We also observed that increased search rates were associated with fewer youth suicide deaths by firearms with a 3-month time lag for adolescents. These models were robust to sensitivity tests.

Conclusions
Although more analysis is needed, the findings are suggestive of an association between increased prosuicide website access and increased suicide deaths, specifically deaths by poisoning and suffocation. These findings emphasize the need to further investigate sites containing potentially dangerous information and their associations with deaths by suicide, as they may affect vulnerable individuals.
Institutional Regulation of the CIS Observer Mission in Election Campaigns and Coverage of Its Activities in the Media
Authors: Malinina S. A. 
Published: April 2024

This study is aimed at studying the institutional, organizational and legal problems of interaction between the media and international observers during elections and referendums in the member states of the Commonwealth of Independent States. The issue of countering foreign interference in the electoral process was not considered in the work.Aim. Eliminate methodological problems in defining the content of the term “international observation”, and proving the need to institutionalize the process of covering the activities of international observers in the media.Tasks. Identify the necessary areas of media activity when covering the activities of international observers during elections and referendums.Methods. The state of the modern election monitoring environment indicates the existence of a fine line between the need to ensure openness of electoral processes and the inadmissibility of interference in the internal affairs of states. It is necessary to identify restrictive thresholds for the activities of the media when covering the processes of international observation of elections and referendums and their institutionalization in relevant advisory documents based on the presumed impartiality of both international observers and the media.Results. The study showed that the most important task of the process of legitimizing the electoral process is to ensure its full coverage of the activities of all its subjects in the media. International monitoring media coverage should cover a wide range of issues throughout the entire electoral process from start to finish, including; activities of observers during the official election campaign before the start of voting; on election day and during the vote counting process; in the period after the elections from the moment the official results are announced until the formation of new authorities. At the same time, at all stages, coverage should cover a wide range of issues of the essence of the electoral process and its management; legal regulation of elections and referendums and existing institutional structures to support the process.Conclusions. Media coverage of the activities of international observers should be considered not only as one of the most important modes of political communication, but also as a means of countering selective absenteeism. Objective and impartial coverage of the activities of international observers in the media can undoubtedly contribute to both the internal political mobilization of the population and the international recognition of the state.
Resultados en la caracterización de la tasa de repetición de imágenes radiográficas convencionales en un hospital pediátrico
Authors: Niño Torres Carlos Fernando , Martínez Polo Gloria Marissa 
Published: April 2024

Hablar de radiología convencional es referirse a imágenes diagnósticas obtenidas mediante radiación ionizante que pueden visualizarse en películas radiográficas o en pantallas de alta resolución. Estas deben cumplir con altos estándares de calidad radiográfica para que el médico radiólogo haga un diagnóstico oportuno y certero. En pacientes pediátricos, al adquirir imágenes, es indispensable observar mayor rigurosidad con el propósito de evitar repetir algún estudio, ya que dicha población es más sensible a la radiación ionizante por tener mayor cantidad de células inmaduras y proliferantes, además por su edad tienen posibilidad de presentar efectos tardíos a lo largo de su vida. Por eso la protección radiológica es importante en esta población y la repetición de imágenes radiográficas debe ser revisada cuidadosamente para evitar daños irreparables.
El propósito de esta investigación fue caracterizar las causales de repetición de imágenes radiográficas tomadas a pacientes pediátricos en una Institución Prestadora de Salud en Bogotá, por medio de un análisis pormenorizado de las causas que originan repetición. En un servicio de radiología que procura prestar servicios de salud con garantía de calidad es necesario tener en cuenta que su finalidad es producir imágenes radiográficas de óptima calidad sin afectar innecesariamente al paciente y al menor costo posible. Por lo anterior, es importante mencionar que, en la implementación del programa de garantía de calidad en radiodiagnóstico, es imprescindible comenzar con la evaluación de imágenes radiográficas que se repiten por no contar con calidad necesaria para el diagnóstico, estableciendo pormenorizadamente sus causas y porcentajes de estas.
Supervised multilabel classification techniques for categorising customer requirements during the conceptual phase in the new product development
Authors: Sutrilastyo  , Astanti Ririn Diar 
Published: April 2024

Abstract
The research aims to provide the decision-maker with a framework for determining customer requirements during product development. The proposed framework is based on sentiment analysis and supervised multilabel classification techniques. Therefore, the proposed technique can categorise customer reviews based on the “product design criteria” label and the “sentiment of the review” label. To achieve the research goal, the research presented in this article uses the existing product development framework presented in the literature. The modification is conducted especially in the conceptual stage of product development, in which the voice of the customer or a customer review is obtained from the scraping, and a multilabel classification technique is performed to categorise customer reviews. The proposed framework is tested by using the set data on women’s clothing reviews from an e-commerce site downloaded from www.kaggle.com based on data by Agarap (2018). The result shows that the proposed framework can categorise customer reviews. The research presented in this paper has contributed by proposing a technique based on sentiment analysis and multilabel classification that can be used to categorise customers during product development. The research presented in this paper answers one of the concerns in the categorisation of needs raised by Shabestari et al. (2019), namely, the unclear rules or main attributes of a requirement that make these needs fall into certain categories. Categorising customer requirements allows decision-makers to determine the direction of product development to meet customer needs.