bluuebunny/crossref_metadata_2025_split huggingface dataset:
Theta-frequency medial septal nucleus deep brain stimulation increases neurovascular activity in MK-801-treated mice
Authors: Crown Lindsey M. , Agyeman Kofi A. , Choi Wooseong , Zepeda Nancy , Iseri Ege , Pahlavan Pooyan , Siegel Steven J. , Liu Charles , Christopoulos Vasileios , Lee Darrin J. 
Published: March 2024

IntroductionDeep brain stimulation (DBS) has shown remarkable success treating neurological and psychiatric disorders including Parkinson’s disease, essential tremor, dystonia, epilepsy, and obsessive-compulsive disorder. DBS is now being explored to improve cognitive and functional outcomes in other psychiatric conditions, such as those characterized by reduced N-methyl-D-aspartate (NMDA) function (i.e., schizophrenia). While DBS for movement disorders generally involves high-frequency (&gt;100 Hz) stimulation, there is evidence that low-frequency stimulation may have beneficial and persisting effects when applied to cognitive brain networks.MethodsIn this study, we utilize a novel technology, functional ultrasound imaging (fUSI), to characterize the cerebrovascular impact of medial septal nucleus (MSN) DBS under conditions of NMDA antagonism (pharmacologically using Dizocilpine [MK-801]) in anesthetized male mice.ResultsImaging from a sagittal plane across a variety of brain regions within and outside of the septohippocampal circuit, we find that MSN theta-frequency (7.7 Hz) DBS increases hippocampal cerebral blood volume (CBV) during and after stimulation. This effect was not present using standard high-frequency stimulation parameters [i.e., gamma (100 Hz)].DiscussionThese results indicate the MSN DBS increases circuit-specific hippocampal neurovascular activity in a frequency-dependent manner and does so in a way that continues beyond the period of electrical stimulation.
Impact of the 2022 national formula shortage on clinical decision-making of healthcare providers in switching amino acid formulas for infants with cow’s milk protein allergy: a survey-based study
Authors: Baran Jessica V. , Brown Jerry M. , Farrar Andrew A. , Oliveros Lea V. , Beacker Jesse , Lamos Luke , Florio Jared , Fabbrini Abigail L. , Wilsey Michael J. 
Published: March 2024

BackgroundIn 2022, the United States experienced a national shortage of infant formula due to a global supply chain crisis and a large-scale domestic formula recall. The existing literature on healthcare providers' (HCPs) clinical decision-making during formula shortages is limited. This study aims to analyze the factors influencing pediatric HCP clinical decision-making when switching between amino acid formulas (AAF) for managing cow's milk protein allergy (CMPA) in infants under 24 months of age during an unprecedented national formula shortage.MethodsThe study included pediatric HCPs with experience managing CMPA in infants and toddlers under 24 months during the formula shortage from January 2022 to November 2022. A de-identified survey comprising 26 questions examining driving factors used in clinical decision-making was administered to pediatric HCPs using a real-time mobile data collection tool.ResultsAmong the surveyed pediatric HCPs (n = 75), the factors most frequently considered as “extremely important” when switching to another AAF included safety (85%), tolerability (73%), and efficacy (83%). No statistically significant differences were found in HCP ratings among the listed examined factors of the four AAFs. The availability of specific formulas was the only factor that exhibited a statistically significant difference in perceived performance among pediatric HCPs when comparing the four AAFs (p &lt; 0.05).DiscussionThis study elucidates the crucial aspects that influenced pediatric HCPs' selection of AAFs for CMPA management during the 2022 formula shortage. The findings highlight the significance of safety, tolerability, efficacy, and availability in the pediatric HCP decision-making processes.
Integration of transcriptomics and metabolomics reveals toxicological mechanisms of ZhuRiHeng drop pill in the 180-day repeated oral toxicity study
Authors: Zhang Qian , Wang Fang , Liu Jing , Li Jun , Zhang Wei , Na Shengsang , Lu Jingkun , Wang Yuewu 
Published: March 2024

Background: ZhuRiHeng Drop Pill (ZRH) is a traditional Mongolian medicinal preparation. Despite its long history of use for the treatment of coronary heart disease, there have been few toxicological studies of the safety profile of ZRH.Purpose: In order to comprehensively elucidate the underlying mechanisms behind the observed toxicity of ZRH on rat livers in the 180-day repeated oral toxicity study, we conducted a comprehensive analysis by integrating transcriptomic and metabolomic data.Methods: High-resolution mass spectrometry was conducted to evaluate the constituents of ZRH. For the acute oral toxicity study, mice were administered a dose of 32 g/(kg·d) of ZRH, while rats were instead orally administered 0.934, 1.868, or 3.736 g/(kg·d) of ZRH over a 180-day period in a 180-day repeated oral toxicity study. Conventional index and organ weights/histology were then monitored to detect any potential ZRH treatment-related toxicity. To identify key genes and metabolites involved in ZRH toxicological processes, we performed transcriptomic and metabolomic analyses of liver tissue upon ZRH treatment using RNA-seq techniques, qPCR and liquid chromatography-mass spectrometry analyses.Results: A total of 60 compounds in ZRH were identified and speculated in positive and negative ion modes. Mice in the acute toxicity study exhibited no signs of ZRH-related toxicity. In a protracted oral toxicity investigation spanning 180 days, discernible elevations in liver ratios were noted in both male and female rats across all three dose cohorts, relative to the control group (p &lt; 0.05 or p &lt; 0.01). Upon subjecting to ZRH treatment, our transcriptomic and qPCR analyses unveiled notable upregulation of crucial genes, exemplified by Abcb1b and Cyp2b2, known for theirs involvement in liver drug transport and metabolism function. Furthermore, our untargeted metabolomic analysis provided supplementary insights, revealing significant regulation in pyrimidine metabolism, as well as alanine, aspartate, and glutamate metabolism pathways.Conclusion: Our study unveils a panoramic understanding of the temporal, dosage-specific, and gene dimensions surrounding the metabolic and transcriptional shifts induced by ZRH exposure. As we peer into the future, recommendations emerge for further exploration, encompassing aspects such as time dynamics, dosage considerations, and gene-centric avenues to enhance therapeutic efficacy.
Long-term benefits of EPs® 7630 in patients with acute sinusitis: a real-world cohort study
Authors: Tisch Matthias , Roháč Lubomír , Reineke Thorsten , Burkart Martin , Kostev Karel 
Published: March 2024

Background: We evaluated whether EPs® 7630 prescription in patients with acute sinusitis (AS) is associated with less frequent recurrence of AS, occurrence of chronic sinusitis or nasal polyps, or fewer antibiotic prescriptions.Methods: This retrospective cohort study used electronic medical records from the IQVIA Disease Analyzer database. Associations between initial therapy [EPs® 7630, antibiotics, intranasal corticosteroid (INCS), or corticosteroid-free nasal spray within 3 days of AS diagnosis] and AS recurrence, incidence of chronic sinusitis or nasal polyps or rate of antibiotic prescription were studied using multivariable Cox or logistic regression models, adjusting for sex, age, insurance status, month of diagnosis, and comorbidity.Results: A total of 216,360 patients were analyzed. INCS prescription was associated with a higher risk of recurrent AS (HR: 1.40; 95% CI: 1.01–1.92) and a higher incidence of chronic sinusitis or nasal polyp diagnosis (HR: 1.39; 95% CI: 1.01–1.92) compared to EPs® 7630. Initial antibiotic therapy was significantly associated with higher risk of new antibiotic prescription in the period of 31–365 days after the index date compared to EPs® 7630 (OR: 2.20; 95% CI: 1.66–2.92).Conclusion: EPs® 7630 prescription is associated with long-term benefits in AS patients. EPs® 7630 can help to reduce inappropriate antibiotic use and might reduce the risk of chronic sinusitis or nasal polyps.
Information literacy in the digital age: information sources, evaluation strategies, and perceived teaching competences of pre-service teachers
Authors: Trixa Jessica , Kaspar Kai 
Published: March 2024

IntroductionInformation literacy has become indispensable in navigating today’s fast-paced media environment, with teachers playing a pivotal role in fostering reflective and critical digital citizenship. Positioned as future gatekeepers, pre-service teachers are the key to teaching media skills and especially information literacy to future generations of pupils. Given the particular challenges facing educators today compared to previous generations, it is important to determine whether the next generation of teachers feel adequately prepared and perceive themselves as competent to pass on these skills to their future pupils. However, previous research has highlighted deficiencies in formal learning opportunities at universities, underscoring the need for further investigation into pre-service teachers’ information acquisition, evaluation practices as well as their perceived relevance to teaching, and person-related factors associated with their perceived competence in teaching information literacy.MethodAn online questionnaire was presented to participants, employing a mixed-method approach. We qualitatively examined the sources of information used by pre-service teachers and the evaluation strategies they employ, while quantitatively analyzing relationships between pre-service teachers’ person-related factors and their perceived teaching competence. Participants assessed their perceived teaching competence, perceived learning opportunities, self-efficacy (general and related to information assessment), perceived informedness, selective exposure, need for cognition, need for cognitive closure, and mistrust in media coverage.ResultsData from 371 participants revealed digital media dominance in information acquisition over traditional sources, albeit with a prevalence of surface-level evaluation strategies over reflective approaches. Two distinct dimensions of perceived competence in teaching information literacy emerged: one focusing on information assessment while the other centers on the understanding of news creation processes. Perceived competence in teaching information literacy was significantly associated with self-efficacy in information assessment, perceived informedness, selective exposure to information as well as perceived learning opportunities focusing on information evaluation. Moreover, pre-service teachers employing diverse information evaluation strategies demonstrated a heightened sense of perceived competence in teaching information assessment.DiscussionOur results provide valuable insights into the multifaceted nature of pre-service teachers’ perceived competence in teaching information literacy. Theoretical implications for future research as well as practical implications for teacher education and the structure of future curricula are discussed.
PTSD prevalence and factors in intern nursing students after COVID-19 full liberalization in China: a cross-sectional study
Authors: Sun Yuanhao , Li Xiangdong , Liu Hairong , Li Xiaoping , Sun Lu , Zhang Lin , Wang Congzhi , Li Jing , Liu Mingming , Zhang Dongmei , Lei Yunxiao , Yuan Ting 
Published: March 2024

ObjectiveThis study aimed to assess the prevalence of post-traumatic stress disorder (PTSD) and its influencing factors among intern nursing students after the full liberalization of the COVID-19 prevention and control policy in China.MethodsParticipants completed the online survey from January 14 to January 19, 2023. A demographic questionnaire, COVID-19 and internship-related questionnaire, the Fear of COVID-19 scale, the Primary Care PTSD Screen, and the Connor-Davidson Resilience Scale were used to conduct the online survey.ResultsOf 438 participants, 88.4% tested positive for COVID-19 in the last 6 months. The prevalence of fear, resilience, and PTSD was 16.9, 15.5, and 11.2%, respectively. Direct care of COVID patients in hospital (OR = 2.084, 95%CI 1.034 ~ 4.202), the experience of occupational exposure (OR = 2.856, 95%CI 1.436 ~ 5.681), working with an experienced team (OR = 2.120, 95%CI 1.070 ~ 4.198), and fear COVID-19 (OR = 8.269, 95%CI 4.150 ~ 16.479) were significantly and positively associated with PTSD in nursing internship students.ConclusionAfter COVID-19 full liberalization in China, intern nursing students still experienced pandemic-related mental distress, which can bring PTSD. Adequate support and counseling should be provided, as needed, to intern nursing students who are about to enter the workforce and have experienced severe PTSD symptoms related to COVID-19. Our findings indicated that should understand the importance of screening, formulate intervention strategies and preventive measures to address psychosocial problems, and provide coping skills training to intern nursing students.
“I’m pulling through because of you”: injured workers’ perspective of workplace factors supporting return to work under the Saskatchewan Workers’ Compensation Board scheme
Authors: Lewis Ian , Houdmont Jonathan 
Published: March 2024

BackgroundResearch demonstrates sustained return to work (RTW) by individuals on medical leave is influenced by personal and job resources and job demands. Relatively few studies have been conducted in the workers’ compensation context that is known to have longer absence durations for RTW.AimsThis study sought to illuminate workers’ experience as they returned to work following a work injury that was either psychological in nature or involved more than 50 days of disability, with a focus on the co-worker, supervisor, and employer actions that supported their return.MethodsWorkers in Saskatchewan, Canada, with a work-related psychological or musculoskeletal injury, subsequent disability, and who returned to work in the last three years, were invited to complete an online survey comprising of free-text questions. Thematic analysis was used to explore participants’ experiences.ResultsResponses from 93 individuals were analysed. These revealed that persistent pain, emotional distress, and loss of normal abilities were present during and beyond returning to work. Almost two-thirds indicated that the supervisors’ and co-workers’ support was critical to a sustained return to work: their needs were recognized and they received autonomy and support to manage work demands. By contrast, one-third indicated that the support they expected and needed from supervisors and employers was lacking.ConclusionsWorkers returning to work lacked personal resources but co-workers’ and supervisors’ support helped improve confidence in their ability to RTW. Supervisors and employers should acknowledge workers’ experiences and offer support and autonomy. Likewise, workers can expect challenges when returning to work and may benefit from cultivating supportive relationships with co-workers and supervisors.
Estudio bibliométrico sobre conciencia ambiental en tratamiento de residuos sólidos en PubMed
Authors: Palacios Garay Jessica Paola , Teves Quispe Julia , Robalino Sanchez Karla 
Published: March 2024

La conciencia ambiental es multidimensional está conformada por cuatro dimensiones definidas: afectiva, cognitiva, conativa y activa. El objetivo de este trabajo es analizar la producción científica sobre la conciencia ambiental en tratamiento de residuos sólidos en PubMed en el período de 2012-2023. La investigación fue desarrollada bajo un diseño observacional, retrospectivo. Fueron utilizadas las palabras claves conciencia ambiental y residuos sólidos. La búsqueda se realizó desde la plataforma de análisis de datos biométricos Bibliometrix () y Biblioshiny app. Se encontraron un total de 159 artículos de 59 fuentes y 699 autores. Se concluye que existe un claro interés de la comunidad científica en el tema de los residuos sólidos, avalado por los trabajos publicados en revistas indexadas en la base PubMed en la década del 2012 al 2023. Sin embargo, no tan claro aparece el tema de la conciencia ambiental referida al manejo de los residuos sólidos.
Pengaruh Green Place Dan Green Promotion Terhadap Keputusan Pembelian Produk Wikstea Pada Mahasiswa Fakultas Kehutanan Universitas Sumatera Utara
Authors: Panjaitan Hendrikson R 
Published: March 2024

This research aims: (1) To determine the influence of green places on purchasing decisions for Wikstea products among students at the Faculty of Forestry, University of North Sumatra. (2) To determine the effect of green promotion on purchasing decisions for Wikstea products among students at the Faculty of Forestry, University of North Sumatra. This research method This type of research is quantitative research and is associative in nature. The results of this research; (1) From the green place statement, in the future the procurement of Wikstea stands/outlets can be further increased to reach new consumers. (2) green promotion statement, it is hoped that the Wikstea company can make advertisements or promotions about the importance of using products that are friendly to living creatures and the environment.

Keywords: Influence, Green Place, Green Promotion.
High tolerant design of athermal Si wavelength filter using Mach–Zehnder interferometer
Authors: Sato Takanori , Maeda Kengo , Sawada Yusuke , Mitarai Takuya , Hiratani Takuo , Okimoto Takuya , Ishikawa Tsutomu , Fujiwara Naoki , Yagi Hideki , Saitoh Kunimasa 
Published: March 2024

Abstract
A design method for the athermal Mach–Zehnder wavelength filter, which is available in the Si-on-insulator platform, is proposed. We can obtain much higher fabrication-tolerant characteristics by introducing a condition, minimizing the dependence of the waveguide width on the athermal condition, to the wavelength filter design. Our design has the arm waveguides divided into four sections, and each section is appropriately designed to exploit athermal characteristics. We also reveal the relationship between the arm length (corresponding to the footprint) and the waveguide width (relating to the propagation loss) from the formularized equations for the wavelength filter design. One example of the Mach–Zehnder interferometer filter designed by the proposed method has lower spectral shift characteristics less than 1 pm K−1 entire C band even if the waveguide width errors occur, compared with the conventional design.
Implementasi Alat Evaluasi Pendidikan Matematika
Authors: Saragih Jessica Dwi Gracia 
Published: March 2024

Abstract

To find out the success of learning, it is necessary to conduct an evaluation, in conducting an evaluation, preparation is needed such as an evaluation tool. An evaluation tool is a tool used to facilitate someone in carrying out a task or achieving a goal more effectively and efficiently. Technological advances are increasingly rapid in an increasingly advanced era. Demand the public to be able to take advantage of information and communication technology. The use of applications in conducting evaluations is of interest to students in the evaluation process. The application can be used as a tool in the learning process so that learning becomes interesting. Some examples of online applications that can be used by educators in the mathematics learning process are the Kahoot application, Ispring Suite 8, Sowfer jeruq.com and Quizizz. These applications are media in the form of web-based interactive learning applications that can be used to create simple quizzes and games, can be accessed by connecting to the internet network and can be used as learning media. This research is a qualitative research with descriptive analysis technique with library research. Based on this literature study, it can be concluded that the use of the application as an evaluation tool has a positive impact on students and teachers in the classroom.

Keyword: Evaluation tools, Tehnology, Learning aplications.

Abstrak

Untuk mengetahui keberhasilan dari pembelajaran perlu melakukan evaluasi, dalam melakukan evaluasi diperlukan persiapan seperti alat evaluasi. Alat evaluasi adalah suatu alat yang digunakan untuk memudahkan seseorang dalam melaksanakan tugas atau mencapai suatu tujuan secara lebih efektif dan efisien. Kemajuan teknologi yang semakin pesat di zaman yang semakin maju. Menuntut masyarakat untuk bisa memanfaatkan teknologi informasi dan komunikasi. Penggunaan aplikasi dalam melakukan evaluasi menjadi ketertarikan bagi siswa dalam proses evaluasi. Aplikasi tersebut dapat dijadikan alat dalam proses pembelajaran agar pembelajaran menjadi menarik. Beberapa contoh aplikasi online yang dapat digunakan pendidik dalam proses pembelajaran matematika adalah aplikasi Kahoot,Ispring Suite 8, Sowfer jeruq.com dan Quizizz. Aplikasi-aplikasi tersebut merupakan media dalam bentuk aplikasi pembelajaran interaktif yang berbasis web yang dapat digunakan untuk membuat kuis dan game sederhana ,dapat diakses dengan tersambung oleh jaringan internetdan dapat menjadi media belajar. Penelitian ini merupakan penelitian kualitatif dengan teknik analisis deskriptif dengan kajian kepustakaan (library research). Berdasarkan studi literatur ini, dapat disimpulkan bahawa penggunaan aplikasi sebagai alat evaluasi berdampak postif bagi siswa dan guru di kelas.

Kata Kunci: Alat Evaluasi, Teknologi. Aplikasi Pembelajaran.
PREVALENSI EKTOPARASIT PADA IKAN NILA (Oreochromis niloticus) YANG DIPELIHARA DALAM KARAMBA DI KELURAHAN PAHANDUT SEBERANG KOTA PALANGKA RAYA
Authors: Rosita Rosita , Matling Matling , Gunawan Irawadi , Gunawan Melky 
Published: March 2024

Penelitian ini bertujuan untuk menganalisis indeks prevalensi ektoparasit pada ikan nila (Oreochromis niloticus) yang dipelihara dalam karamba di Kelurahan Pahandut Seberang Kota Palangka Raya. Penelitian ini dilaksanakan tanggal 1-30 Agustus 2023 Metode yang digunakan adalah metode observasi dengan teknik pengambilan sampel secara purposive sampling dengan interval Sampling dilakukan 1 minggu dengan jumlah sampel 20 ekor ikan sehingga total jumlah ikan sampel 60 ekor. Identifikasi ektoparasit dilakukan di Laboratorium Stasiun Karantina Ikan Pengendalian Mutu dan Keamanan Hasil Perikanan (SKIPM) Kota Palangka Raya, Prov. Kalimantan Tengah. Hasil identifikasi ditemukan 3 jenis ektoparasit dari dua golongan yaitu dari golongan metazoa (Gyrodactylus sp) dan protozoa (Chilodonella sp dan Vorticella sp.). Kisaran prevalensi ektoparasit sebesar 40%-60% dengan tingkat prevalensi yang paling tinggi ditemukan pada sampling I dengan nilai prevalensi sebesar 60% dengan ektoparasit Gyrodctylus sp 17 ind/ekor, Vortycella sp 2 ind/ekor dan Chilodonella sp 14 ind/ekor, prevalensi yang paling rendah ditemukan pada Sampling II dengan nilai prevalensi sebesar 40% dengan jumlah ektoparasit Gyrodctylus sp 8 sel, Vortycella sp 9 sel dan Chilodonella sp 18 sel. Pada organ target kisaran prevalensi ektoparasit sebesar 40%-80% dimana prevalensi ektoparasit tertinggi pada organ insang sebesar 80% dan terendah pada sirip ekor sebesar 40%. Kisaran prevalensi individu parasit berkisar antara 90%-66,7% dimana prevalensi ektoparasit tertinggi adalah parasit Chilodonella sp sebesar 90% dan yang terendah adalah Vorticella sp sebesar 66,7%.