bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interchannel Error Correlation Associated with AIRS Radiance Observations: Inference and Impact in Data Assimilation
Authors: Garand Louis , Heilliette Sylvain , Buehner Mark 
Published: July 2007

Abstract
The interchannel observation error correlation (IOEC) associated with radiance observations is currently assumed to be zero in meteorological data assimilation systems. This assumption may lead to suboptimal analyses. Here, the IOEC is inferred for the Atmospheric Infrared Radiance Sounder (AIRS) hyperspectral radiance observations using a subset of 123 channels covering the spectral range of 4.1–15.3 μm. Observed minus calculated radiances are computed for a 1-week period using a 6-h forecast as atmospheric background state. A well-established technique is used to separate the observation and background error components for each individual channel and each channel pair. The large number of collocations combined with the 40-km horizontal spacing between AIRS fields of view allows robust results to be obtained. The resulting background errors are in good agreement with those inferred from the background error matrix used operationally in data assimilation at the Meteorological Service of Canada. The IOEC is in general high among the water vapor–sensing channels in the 6.2–7.2-μm region and among surface-sensitive channels. In contrast, it is negligible for channels within the main carbon dioxide absorption band (13.2–15.4 μm). The impact of incorporating the IOEC is evaluated from 1D variational retrievals at 381 clear-sky oceanic locations. Temperature increments differ on average by 0.25 K, and ln(q) increments by 0.10, where q is specific humidity. Without IOEC, the weight given to the observations appears to be too high; the assimilation attempts to fit the observations nearly perfectly. The IOEC better constrains the variational assimilation process, and the rate of convergence is systematically faster by a factor of 2.
Modeling the Variability of Drop Size Distributions in Space and Time
Authors: Lee Gyu Won , Seed Alan W. , Zawadzki Isztar 
Published: July 2007

Abstract
The information on the time variability of drop size distributions (DSDs) as seen by a disdrometer is used to illustrate the structure of uncertainty in radar estimates of precipitation. Based on this, a method to generate the space–time variability of the distributions of the size of raindrops is developed. The model generates one moment of DSDs that is conditioned on another moment of DSDs; in particular, radar reflectivity Z is used to obtain rainfall rate R. Based on the fact that two moments of the DSDs are sufficient to capture most of the DSD variability, the model can be used to calculate DSDs and other moments of interest of the DSD. A deterministic component of the precipitation field is obtained from a fixed R–Z relationship. Two different components of DSD variability are added to the deterministic precipitation field. The first represents the systematic departures from the fixed R–Z relationship that are expected from different regimes of precipitation. This is generated using a simple broken-line model. The second represents the fluctuations around the R–Z relationship for a particular regime and uses a space–time multiplicative cascade model. The temporal structure of the stochastic fluctuations is investigated using disdrometer data. Assuming Taylor hypothesis, the spatial structure of the fluctuations is obtained and a stochastic model of the spatial distribution of the DSD variability is constructed. The consistency of the model is validated using concurrent radar and disdrometer data.
An Efficient Route to Cyclic Polymers by ATRP–RCM Process
Authors: Hayashi Shotaro , Adachi Kaoru , Tezuka Yasuyuki 
Published: July 2007

Abstract
An efficient synthetic route to cyclic polymers has been demonstrated through atom-transfer radical polymerization (ATRP) and subsequent ring-closing metathesis (RCM) reaction. Thus, telechelic poly(methyl acrylate) (PMA) having allyl groups was synthesized by ATRP of methyl acrylate with a difunctional initiator and the subsequent end-capping reaction with allyltributyltin. The following RCM reaction proceeded even under dilution in the presence of the Grubbs catalyst to give a cyclic PMA in a high yield.
Plastic Shottky Barriers Fabricated by a Line Patterning Technology
Authors: Yan Hu , Endo Shunsuke , Hara Yusuke , Okuzaki Hidenori 
Published: July 2007

Abstract
Plastic Shottky barriers were fabricated using poly(3,4-ethylenedioxythiophene) doped with poly(4-styrenesulfonate) (PEDOT:PSS) and aluminum as the p-type semiconductor and the metal, respectively, by a facile line-patterning technology in which multiple-line-patterning was utilized for the designed patterns. Based on the measurements of current–voltage and capacitance–voltage characteristics, various electrical parameters of the Shottky barriers were extracted. As a result, the barrier height, work function of the PEDOT:PSS and rectification ratio were 0.78, 4.8 eV and 1.6×102, respectively.
Synthesis, Structure, and Properties of Three- and Six-Membered Metallacycles Composed of Iron, Germanium, and Sulfur Atoms
Authors: Okazaki Masaaki , Kimura Hiromitsu , Komuro Takashi , Okada Hiroshi , Tobita Hiromi 
Published: July 2007

Abstract
Ultraviolet irradiation of Cp∗(CO)2FeGeMe2SPh in the presence of acetone afforded trans-[Cp∗Fe(CO){μ-κ2Ge,S-GeMe2SPh}]2, while the introduction of a bulkier substituent on the sulfur atom allowed selective formation of the three-membered metallacycle Cp∗(CO)Fe{κ2Ge,S-GeMe2SMes} (Mes = 2,4,6-C6H2Me3).
Comparison of Different Intravenous Bisphosphonate Regimens for Paget's Disease of Bone
Authors: Merlotti Daniela , Gennari Luigi , Martini Giuseppe , Valleggi Fabrizio , De Paola Vincenzo , Avanzati Annalisa , Nuti Ranuccio 
Published: July 2007

AbstractThis randomized study compared different intravenous bisphosphonates in PDB. Zoledronate was superior with respect to pamidronate in achieving biochemical remission, with therapeutic response maintained in most patients at 15 mo. Single neridronate and zoledronate infusion showed a similar efficacy in up to 90% of patients nonresponders to pamidronate.Introduction: Intravenous bisphosphonates represent a common therapy for Paget's disease of bone (PDB). However, there have been few head to head randomized trials comparing intravenous bisphosphonates.Materials and Methods: We performed a 15-mo, randomized study comparing different intravenous bisphosphonates in 90 subjects with active PDB. At baseline, patients were randomly assigned to receive pamidronate (30 mg, IV, for 2 consecutive days every 3 mo; n = 60) or zoledronate (4 mg, IV; n = 30). After 6 mo, nonresponders to pamidronate were crossed over to zoledronate or neridronate (100 mg, IV, for 2 consecutive days). The primary efficacy endpoint was therapeutic response at 6 mo, defined as normalization of alkaline phosphatase (ALP) or a reduction of at least 75% in total ALP excess.Results: At 6 mo, 97% of patients receiving zoledronate had a therapeutic response compared with 45% of patients receiving pamidronate. Normalization of ALP was achieved in 93% of patients in the zoledronate group and in 35% of patients in the pamidronate group. ALP normalization was maintained in 79% and 65% of zoledronate-treated patients after 12 and 15 mo, respectively; loss of therapeutic response was observed in 2 of 30 (6%) at 12 and 15 mo. At 6 mo, 27 patients showing therapeutic response to pamidronate continued the treatment, whereas nonresponders were crossed-over to neridronate (n = 15) or zoledronate (n = 18). Among these subjects, 14 of 15 (93%) in the neridronate group and 17 of 18 (94%) in the zoledronate group achieved a therapeutic response. Similar normalization rates were observed between neridronate- (80%) and zoledronate- (83%) treated subjects. Normalization and therapeutic response were maintained at 9 mo from treatment (corresponding to 15 mo from the baseline visit) in either neridronate or zoledronate groups.Conclusions: Single neridronate and zoledronate infusion showed a similar efficacy in achieving biochemical remission in up to 90% of patients nonresponders to pamidronate. Therapeutic response to zoledronate seems to be maintained in most patients at 15 mo.
Cytotype Regulation by TelomericPElements inDrosophila melanogaster: Evidence for Involvement of an RNA Interference Gene
Authors: Simmons Michael J , Ryzek Don-Felix , Lamour Cecile , Goodman Joseph W , Kummer Nicole E , Merriman Peter J 
Published: July 2007

AbstractP elements inserted at the left telomere of the X chromosome evoke the P cytotype, a maternally inherited condition that regulates the P-element family in the Drosophila germline. This regulation is completely disrupted in stocks heterozygous for mutations in aubergine, a gene whose protein product is involved in RNA interference. However, cytotype is not disrupted in stocks heterozygous for mutations in two other RNAi genes, piwi and homeless (spindle-E), or in a stock heterozygous for a mutation in the chromatin protein gene Enhancer of zeste. aubergine mutations exert their effects in the female germline, where the P cytotype is normally established and through which it is maintained. These effects are transmitted maternally to offspring of both sexes independently of the mutations themselves. Lines derived from mutant aubergine stocks reestablish the P cytotype quickly, unlike lines derived from stocks heterozygous for a mutation in Suppressor of variegation 205, the gene that encodes the telomere-capping protein HP1. Cytotype regulation by telomeric P elements may be tied to a system that uses RNAi to regulate the activities of telomeric retrotransposons in Drosophila.
A Dense Single-Nucleotide Polymorphism-Based Genetic Linkage Map of Grapevine (Vitis viniferaL.) Anchoring Pinot Noir Bacterial Artificial Chromosome Contigs
Authors: Troggio Michela , Malacarne Giulia , Coppola Giuseppina , Segala Cinzia , Cartwright Dustin A , Pindo Massimo , Stefanini Marco , Mank Rolf , Moroldo Marco , Morgante Michele , Grando M Stella , Velasco Riccardo 
Published: July 2007

AbstractThe construction of a dense genetic map for Vitis vinifera and its anchoring to a BAC-based physical map is described: it includes 994 loci mapped onto 19 linkage groups, corresponding to the basic chromosome number of Vitis. Spanning 1245 cM with an average distance of 1.3 cM between adjacent markers, the map was generated from the segregation of 483 single-nucleotide polymorphism (SNP)-based genetic markers, 132 simple sequence repeats (SSRs), and 379 AFLP markers in a mapping population of 94 F1 individuals derived from a V. vinifera cross of the cultivars Syrah and Pinot Noir. Of these markers, 623 were anchored to 367 contigs that are included in a physical map produced from the same clone of Pinot Noir and covering 352 Mbp. On the basis of contigs containing two or more genetically mapped markers, region-dependent estimations of physical and recombinational distances are presented. The markers used in this study include 118 SSRs common to an integrated map derived from five segregating populations of V. vinifera. The positions of these SSR markers in the two maps are conserved across all Vitis linkage groups. The addition of SNP-based markers introduces polymorphisms that are easy to database, are useful for evolutionary studies, and significantly increase the density of the map. The map provides the most comprehensive view of the Vitis genome reported to date and will be relevant for future studies on structural and functional genomics and genetic improvement.
Synthetic Lethality of Drosophila in the Absence of the MUS81 Endonuclease and the DmBlm Helicase Is Associated With Elevated Apoptosis
Authors: Trowbridge Kirsten , McKim Kim , Brill Steven J , Sekelsky Jeff 
Published: July 2007

Abstract
Mus81-Mms4 (Mus81-Eme1 in some species) is a heterodimeric DNA structure-specific endonuclease that has been implicated in meiotic recombination and processing of damaged replication forks in fungi. We generated and characterized mutations in Drosophila melanogaster mus81 and mms4. Unlike the case in fungi, we did not find any role for MUS81-MMS4 in meiotic crossing over. A possible role for this endonuclease in repairing double-strand breaks that arise during DNA replication is suggested by the finding that mus81 and mms4 mutants are hypersensitive to camptothecin; however, these mutants are not hypersensitive to other agents that generate lesions that slow or block DNA replication. In fungi, mus81, mms4, and eme1 mutations are synthetically lethal with mutations in genes encoding RecQ helicase homologs. Similarly, we found that mutations in Drosophila mus81 and mms4 are synthetically lethal with null mutations in mus309, which encodes the ortholog of the Bloom Syndrome helicase. Synthetic lethality is associated with high levels of apoptosis in proliferating tissues. Lethality and elevated apoptosis were partially suppressed by a mutation in spn-A, which encodes the ortholog of the strand invasion protein Rad51. These findings provide insights into the causes of synthetic lethality.
A Gain-of-Function Screen for Genes That Influence Axon Guidance Identifies the NF-κB Protein Dorsal and Reveals a Requirement for the Kinase Pelle in Drosophila Photoreceptor Axon Targeting
Authors: Mindorff Elizabeth N , O'Keefe David D , Labbé Alain , Yang Jennie Ping , Ou Yimiao , Yoshikawa Shingo , van Meyel Donald J 
Published: July 2007

Abstract
To identify novel regulators of nervous system development, we used the GAL4-UAS misexpression system in Drosophila to screen for genes that influence axon guidance in developing embryos. We mobilized the Gene Search (GS) P element and identified 42 lines with insertions in unique loci, including leak/roundabout2, which encodes an axon guidance receptor and confirms the utility of our screen. The genes we identified encode proteins of diverse classes, some acting near the cell surface and others in the cytoplasm or nucleus. We found that one GS line drove misexpression of the NF-κB transcription factor Dorsal, causing motor axons to bypass their correct termination sites. In the developing visual system, Dorsal misexpression also caused photoreceptor axons to reach incorrect positions within the optic lobe. This mistargeting occurred without observable changes of cell fate and correlated with localization of ectopic Dorsal in distal axons. We found that Dorsal and its inhibitor Cactus are expressed in photoreceptors, though neither was required for axon targeting. However, mutation analyses of genes known to act upstream of Dorsal revealed a requirement for the interleukin receptor-associated kinase family kinase Pelle for layer-specific targeting of photoreceptor axons, validating our screen as a means to identify new molecular determinants of nervous system development in vivo.
Synteny and Chromosome Evolution in the Lepidoptera: Evidence From Mapping in Heliconius melpomene
Authors: Pringle Elizabeth G , Baxter Simon W , Webster Claire L , Papanicolaou Alexie , Lee Siu F , Jiggins Chris D 
Published: July 2007

Abstract
The extent of conservation of synteny and gene order in the Lepidoptera has been investigated previously only by comparing a small subset of linkage groups between the moth Bombyx mori and the butterfly Heliconius melpomene. Here we report the mapping of 64 additional conserved genes in H. melpomene, which contributed 47 markers to a comparative framework of 72 orthologous loci spanning all 21 H. melpomene chromosomes and 27 of the 28 B. mori chromosomes. Comparison of the maps revealed conserved synteny across all chromosomes for the 72 loci, as well as evidence for six cases of chromosome fusion in the Heliconius lineage that contributed to the derived 21-chromosome karyotype. Comparisons of gene order on these fused chromosomes revealed two instances of colinearity between H. melpomene and B. mori, but also one instance of likely chromosomal rearrangement. B. mori is the first lepidopteran species to have its genome sequenced, and the finding that there is conserved synteny and gene order among Lepidoptera indicates that the genomic tools developed in B. mori will be broadly useful in other species.
A Clonal Genetic Screen for Mutants Causing Defects in Larval Tracheal Morphogenesis in Drosophila
Authors: Baer Magdalena M , Bilstein Andreas , Leptin Maria 
Published: July 2007

AbstractThe initial establishment of the tracheal network in the Drosophila embryo is beginning to be understood in great detail, both in its genetic control cascades and in its cell biological events. By contrast, the vast expansion of the system during larval growth, with its extensive ramification of preexisting tracheal branches, has been analyzed less well. The mutant phenotypes of many genes involved in this process are probably not easy to reveal, as these genes may be required for other functions at earlier developmental stages. We therefore conducted a screen for defects in individual clonal homozygous mutant cells in the tracheal network of heterozygous larvae using the mosaic analysis with a repressible cell marker (MARCM) system to generate marked, recombinant mitotic clones. We describe the identification of a set of mutants with distinct phenotypic effects. In particular we found a range of defects in terminal cells, including failure in lumen formation and reduced or extensive branching. Other mutations affect cell growth, cell shape, and cell migration.
Temporal Control of Cell-Specific Transgene Expression inCaenorhabditis elegans
Authors: Bacaj Taulant , Shaham Shai 
Published: July 2007

AbstractCell-specific promoters allow only spatial control of transgene expression in Caenorhabditis elegans. We describe a method, using cell-specific rescue of heat-shock factor-1 (hsf-1) mutants, that allows spatial and temporal regulation of transgene expression. We demonstrate the utility of this method for timed reporter gene expression and for temporal studies of gene function.
Comparative Analyses Between Lolium/Festuca Introgression Lines and Rice Reveal the Major Fraction of Functionally Annotated Gene Models Is Located in Recombination-Poor/Very Recombination-Poor Regions of the Genome
Authors: King Julie , Armstead Ian P , Donnison S Iain , Roberts Luned A , Harper John A , Skøt Kirsten , Elborough Kieran , King Ian P 
Published: July 2007

Abstract
Publication of the rice genome sequence has allowed an in-depth analysis of genome organization in a model monocot plant species. This has provided a powerful tool for genome analysis in large-genome unsequenced agriculturally important monocot species such as wheat, barley, rye, Lolium, etc. Previous data have indicated that the majority of genes in large-genome monocots are located toward the ends of chromosomes in gene-rich regions that undergo high frequencies of recombination. Here we demonstrate that a substantial component of the coding sequences in monocots is localized proximally in regions of very low and even negligible recombination frequencies. The implications of our findings are that during domestication of monocot plant species selection has concentrated on genes located in the terminal regions of chromosomes within areas of high recombination frequency. Thus a large proportion of the genetic variation available for selection of superior plant genotypes has not been exploited. In addition our findings raise the possibility of the evolutionary development of large supergene complexes that confer a selective advantage to the individual.
Successful Intermittent Prophylaxis With Trimethoprim/Sulfamethoxazole 2 Days per Week for Pneumocystis carinii (jiroveci) Pneumonia in Pediatric Oncology Patients
Authors: Lindemulder Susan , Albano Edythe 
Published: July 2007

OBJECTIVE. This study was conducted to determine the efficacy of dosing trimethoprim/sulfamethoxazole on 2 consecutive days per week for the prevention of Pneumocystis carinii (jiroveci) pneumonia in a pediatric leukemia and lymphoma population and to determine whether trimethoprim/sulfamethoxazole contributes to neutropenia during maintenance therapy.
METHODS. Charts were reviewed for all pediatric patients with leukemia and lymphoma diagnosed between January 1, 1993, and December 31, 2002. Data were collected through April 1, 2004.
RESULTS. A total of 575 charts were reviewed; 529 patients were included in the analysis. A total of 482 (345 leukemia, 137 lymphoma) patients were evaluated on trimethoprim/sulfamethoxazole dosed 2 consecutive days per week for 268074 patient-days. No breakthrough cases were documented in compliant patients; 2 noncompliant patients developed P carinii pneumonia. A total of 238 patients who were on trimethoprim/sulfamethoxazole prophylaxis and 13 patients who were receiving an alternative medication prophylaxis were evaluated for neutropenia during maintenance therapy. The median number of maintenance days on trimethoprim/sulfamethoxazole was 605.5 days and on alternative drug was 617 days. The median number of neutropenic maintenance days on trimethoprim/sulfamethoxazole was 15.5 days and on the alternative drug was 16 days. The median proportion of neutropenic days per patient was 0.029 on trimethoprim/sulfamethoxazole and 0.022 on the alternative drug.
CONCLUSIONS. Intermittent dosing of trimethoprim/sulfamethoxazole on 2 consecutive days per week is an effective alternative prophylactic regimen for P carinii pneumonia in pediatric patients with leukemia and lymphoma. This analysis does not support a difference in neutropenia during maintenance therapy between patients who are treated with trimethoprim/sulfamethoxazole versus an alternative drug.
Is Victimization From Bullying Associated With Medicine Use Among Adolescents? A Nationally Representative Cross-sectional Survey in Denmark
Authors: Due Pernille , Hansen Ebba Holme , Merlo Juan , Andersen Anette , Holstein Bjørn E. 
Published: July 2007

OBJECTIVE. The goal was to examine whether being a victim of bullying was associated with medicine use, taking into account the increased prevalence of physical and psychological symptoms.
METHODS. The study population included all students in grades 5, 7, and 9 (mean ages: 11.6, 13.6, and 15.6 years, respectively) in a random sample of schools in Denmark (participation rate: 88.5%; N = 5205). The students reported health problems, medicine use, bullying, and a range of psychosocial conditions in an anonymous standardized questionnaire. The outcome measure was self-reported medicine use for headache, stomachache, difficulties in getting to sleep, and nervousness. The determinant was frequency of exposure to bullying, measured with 1 item.
RESULTS. In multivariate models adjusted for age and social class, we found that adolescent victims of bullying used medicine for pains and psychological problems more often than did adolescents who were not bullied. The increased odds of using medicine were not explained by the higher prevalence of symptoms among the bullied children.
CONCLUSIONS. We found victimization from bullying to be associated with medicine use, even when we controlled for the higher prevalence of symptoms among bullied victims. The medications that adolescents use can have adverse effects, in addition to the potentially health-damaging effects of bullying. Policy makers, health care professionals, and school staff should be aware that the adolescent victims of bullying are prone to excess use of medicine, and preventive actions should be taken to decrease the level of bullying as well as the use of medicine among adolescents.