bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis of New Cyclopropylisonitriles and Their Applications in Ugi Four‐Component Reactions.
Authors: Osipova Anna , Yufit Dmitrii S. , de Meijere Armin 
Published: April 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
GaCl3‐Catalyzed Addition of Thiols to Glycals: A Facile Synthesis of 2‐Deoxy Thioglycosides.
Authors: Yadav J. S. , Reddy B. V. Subba , Bhasker E. Vijaya , Raghavendra S. , Narsaiah A. V. 
Published: April 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Addition Reaction of O‐Toluamides with Chiral Auxiliary Derived from 2‐Amino‐1,3‐propanediols to Imines.
Authors: Chrzanowska Maria , Dreas Agnieszka 
Published: April 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Suzuki—Miyaura Cross‐Coupling of Unprotected Halopurine Nucleosides in Water—Influence of Catalyst and Cosolvent.
Authors: Collier Alice , Wagner Gerd K. 
Published: April 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Malyngamide X (I): The First (7R)‐Lyngbic Acid that Connects to a New Tripeptide Backbone from the Thai Sea Hare Bursatella leachii
Authors: Suntornchashwej Suchada , Suwanborirux Khanit , Koga Kazushi , Isobe Minoru 
Published: April 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Catalytic Asymmetric Synthesis of Mycocerosic Acid.
Authors: ter Horst Bjorn , Feringa Ben L. , Minnaard Adriaan J. 
Published: April 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Total Synthesis of 4′′‐O‐Acetylmananthoside B. Part 1. Synthesis and Tentative Ozonolysis of a Cyclohexadiene Derivative.
Authors: Zhao Guilong , Jia Jiong , Liu Junzhi , Wang Jianwu 
Published: April 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Diaporthichalasin, a Novel CYP3A4 Inhibitor from an Endophytic Diaporthe sp.
Authors: Pornpakakul Surachai , Roengsumran Sophon , Deechangvipart Suchon , Petsom Amorn , Muangsin Nongnuch , Ngamrojnavanich Nattaya , Sriubolmas Nongluksna , Chaichit Narongsak , Ohta Tomihisa 
Published: April 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Structural and Mechanistic Investigation of Rubidium Ion Exchange in Potassium Zirconium Trisilicate.
Authors: Fewox Christopher S. , Kirumakki Sharath R. , Clearfield Abraham 
Published: April 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
FePt@CoS2 Yolk—Shell Nanocrystals as a Potent Agent to Kill HeLa Cells.
Authors: Gao Jinhao , Liang Gaolin , Zhang Bei , Kuang Yi , Zhang Xixiang , Xu Bing 
Published: April 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Converting Metals into Phosphides: A General Strategy for the Synthesis of Metal Phosphide Nanocrystals.
Authors: Henkes Amanda E. , Vasquez Yolanda , Schaak Raymond E. 
Published: April 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Crystallographic and Structural Analysis of Iron Heterometallic Compounds. Part 1. Heterobinuclear Compounds
Authors: Melnik Milan , Baloghova Zuzana , Ondrejkovicova Iveta , Vancova Vlasta , Holloway Clive 
Published: April 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Dark‐Red O8 Molecules in Solid Oxygen: Rhomboid Clusters, Not S8‐Like Rings
Authors: Steudel Ralf , Wong Ming Wah 
Published: April 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Sulfur‐Containing Chiral Ferrocene Derivatives: Synthesis and Applications
Authors: Bonini Bianca F. , Fochi Mariafrancesca , Ricci Alfredo 
Published: April 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Molecular and Supramolecular C60—Oligophenylenevinylene Conjugates
Authors: Figueira‐Duarte Teresa M. , Gegout Aline , Nierengarten Jean‐Francois 
Published: April 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Palladium‐Based Catalytic Systems for the Synthesis of Conjugated Enynes by Sonogashira Reactions and Related Alkynylations
Authors: Doucet Henri , Hierso Jean‐Cyrille 
Published: April 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Catalytic Aryl—Aryl Coupling via Cleavage of C—H or C—C Bond
Authors: Satoh Tetsuya , Miura Masahiro 
Published: April 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Ball‐, Bowl‐, and Belt‐Shaped Conjugated Systems and Their Complexing Abilities: Exploration of the Concave—Convex π—π Interaction
Authors: Kawase Takeshi , Kurata Hiroyuki 
Published: April 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Thiacalixarenes
Authors: Morohashi Naoya , Narumi Fumitaka , Iki Nobuhiko , Hattori Tetsutaro , Miyano Sotaro 
Published: April 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Biomolecule—Nanoparticle Hybrids as Functional Units for Nanobiotechnology
Authors: Baron Ronan , Willner Bilha , Willner Itamar 
Published: April 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Imatinib compared with chemotherapy as front‐line treatment of elderly patients with Philadelphia chromosome‐positive acute lymphoblastic leukemia (Ph+ALL)
Authors: Ottmann Oliver G. , Wassmann Barbara , Pfeifer Heike , Giagounidis Aristoteles , Stelljes Matthias , Dührsen Ulrich , Schmalzing Marc , Wunderle Lydia , Binckebanck Anja , Hoelzer Dieter 
Published: April 2007

AbstractBACKGROUNDElderly patients with Philadelphia chromosome‐positive acute lymphoblastic leukemia (Ph+ALL) have a poor prognosis, with a low complete remission (CR) rate, high induction mortality, and short remission duration. Imatinib (IM) has a favorable toxicity profile but limited antileukemic activity in advanced Ph+ALL. Imatinib in combination with intensive chemotherapy has yielded promising results as front‐line therapy, but its value as monotherapy in newly diagnosed Ph+ALL is not known.METHODSPatients with de novo Ph+ALL were randomly assigned to induction therapy with either imatinib (IndIM) or multiagent, age‐adapted chemotherapy (Indchemo). Imatinib was subsequently coadministered with consolidation chemotherapy.RESULTSIn all, 55 patients (median age, 68 years) were enrolled. The overall CR rate was 96.3% in patients randomly assigned to IndIM and 50% in patients allocated to Indchemo (P = .0001). Nine patients (34.6%) were refractory and 2 patients died during Indchemo; none failed imatinib induction. Severe adverse events were significantly more frequent during Indchemo (90% vs 39%; P = .005). The estimated overall survival (OS) of all patients was 42% ± 8% at 24 months, with no significant difference between the 2 cohorts. Median disease‐free survival was significantly longer in the 43% of patients (21 of 49 evaluable) in whom BCR‐ABL transcripts became undetectable (18.3 months vs 7.2 months; P = .002).CONCLUSIONSIn elderly patients with de novo Ph+ALL, imatinib induction results in a significantly higher CR rate and lower toxicity than induction chemotherapy. With subsequent combined imatinib and chemotherapy consolidation, this initial benefit does not translate into improved survival compared with chemotherapy induction. Cancer 2007. © 2007 American Cancer Society.
Infectious complications of monoclonal antibodies used in cancer therapy
Authors: Rafailidis Petros I. , Kakisi Ourania K. , Vardakas Konstantinos , Falagas Matthew E. 
Published: April 2007

AbstractThe introduction of monoclonal antibodies (MoAbs) into the treatment of cancer has led to improvements in patient survival. However, to the authors' knowledge, little attention has been paid to the infectious complications associated with their use. The authors performed a systematic review of the literature to identify randomized controlled trials (RCTs) that included in their outcomes a comparison of the infectious complications of a MoAb plus chemotherapy or radiotherapy versus the therapy regimen given without the addition of a MoAb. Twenty RCTs with relevant data regarding the use of MoAbs in patients with hematologic malignancies (10 RCTs) and solid tumors (10 RCTs) were retrieved. Six RCTs compared rituximab in conjunction with the combination of cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) versus CHOP alone for the treatment of B‐cell non‐Hodgkin lymphoma (NHL). No significant increase in the incidence of infections was observed with the addition of rituximab to chemotherapy (based on data from 5 RCTs). However, in patients who were seropositive for the human immunodeficiency virus (HIV), a 12% increase in infection‐related deaths and a rate of higher opportunistic infections was associated with the rituximab‐containing regimen (data taken from 1 RCT). Five RCTs either compared trastuzumab plus chemotherapy versus chemotherapy alone or trastuzumab monotherapy versus observation in patients with breast cancer. The addition of trastuzumab to the various chemotherapy regimens was found to cause a slight increase in the frequency of high‐grade infections while bevacizumab caused a negligible increase in Grade III/IV infections compared with the same regimens given of chemotherapy alone. Based on a single trial, a higher comparable increase in the rate of high‐grade infections was noted with the use of cetuximab in addition to chemotherapy compared with chemotherapy alone. MoAbs added to chemotherapy appear to have infectious complications that are comparable to the chemotherapy‐alone regimen when administered for the treatment of NHL, with the exception of HIV‐seropositive patients. Trastuzumab, which is reported to have a clear benefit in the prognosis of breast cancer patients, was found to cause a small increase in Grade III/IV infectious complications; however, there was no apparent difference in the rate of infection‐related death. Cancer 2007. © 2007 American Cancer Society.
On the scattering frequencies of the laplace operator for exterior domains
Authors: Lax Peter D. , Phillips Ralph S. 
Published: April 2007

AbstractIn this paper we show that the so‐called scattering frequencies of the Laplace operator over an exterior domain, subject to Robin or Dirichlet boundary condition, cannot lie in certain portions of the upper half‐plane. The excluded sets depend only on the type of boundary condition and the radius of the smallest sphere containing the scattering obstacle.
A Combined Experimental and Computational Study on the Ionization Energies of the Cyclic and Linear C3H Isomers
Authors: Kaiser Ralf I. , Belau Leonid , Leone Stephen R. , Ahmed Musahid , Wang Yimin , Braams Bastiaan J. , Bowman Joel M. 
Published: April 2007

AbstractFor the first time, two hydrogen‐deficient hydrocarbon radicals are generated in situ via laser ablation of graphite and seeding the ablated species in acetylene gas, which acts as a carrier and reactant simultaneously. By recording photoionization efficiency curves (PIE) and simulating the experimental spectrum with computed Franck–Condon (FC) factors, we can reproduce the general pattern of the PIE curve of m/z=37. We recover ionization energies of 9.15 eV and 9.76 eV for the linear and cyclic isomers, respectively. Our combined experimental and theoretical studies provide an unprecedented, versatile pathway to investigate the ionization energies of even more complex hydrocarbon radicals in situ, which are difficult to prepare by classical synthesis, in future experiments.
WC1+ γδ T cell memory population is induced by killed bacterial vaccine
Authors: Blumerman Seth L. , Herzig Carolyn T. A. , Baldwin Cynthia L. 
Published: April 2007

AbstractLimited studies have addressed the ability of γδ T cells to become memory populations. We previously demonstrated that WC1.1+ γδ T cells from ruminants vaccinated with killed Leptospira borgpetersenii proliferate and produce IFN‐γ in recall responses. Here we show that this response is dependent upon antigen‐responsive CD4 T cells, at least across transwell membranes; this requirement cannot be replaced by IL‐2. The response was also dependent upon in vivo priming, since γδ T cells from leptospira vaccine‐naive animals did not respond to antigen even when co‐cultured across membranes from antigen‐responsive PBMC. γδ T cells were the major antigen‐responding T cell population for the first 4 wks following vaccination and replicated more rapidly than CD4 T cells. Primed WC1+ γδ T cells circulated as CD62Lhi/CD45ROint/CD44lo, characteristics of TCM cells. When stimulated with antigen, they decreased CD62L, increased CD44 and CD25, and had no change in CD45RO expression. These changes paralleled those of the leptospira antigen‐responsive CD4 T cells but differed from those of γδ T cells proliferating to mitogen stimulation. This system for in vivo γδ T cell priming is unique, since it relies on a killed antigen to induce memory and may be pertinent to designing vaccines that require type 1 pro‐inflammatory cytokines.
Enhanced immunogenicity of CTL antigens through mutation of the CD8 binding MHC class I invariant region
Authors: Wooldridge Linda , Lissina Anna , Vernazza Jonathan , Gostick Emma , Laugel Bruno , Hutchinson Sarah L. , Mirza Fareed , Dunbar P. Rod , Boulter Jonathan M. , Glick Meir , Cerundolo Vincenzo , van den Berg Hugo A. , Price David A. , Sewell Andrew K. 
Published: April 2007

AbstractCD8+ cytotoxic T lymphocytes (CTL) are key determinants of immunity to intracellular pathogens and neoplastic cells. Recognition of specific antigens in the form of peptide‐MHC class I complexes (pMHCI) presented on the target cell surface is mediated by T cell receptor (TCR) engagement. The CD8 coreceptor binds to invariant domains of pMHCI and facilitates antigen recognition. Here, we investigate the biological effects of a Q115E substitution in the α2 domain of human leukocyte antigen (HLA)‐A*0201 that enhances CD8 binding by ∼50% without altering TCR/pMHCI interactions. Soluble and cell surface‐expressed forms of Q115E HLA‐A*0201 exhibit enhanced recognition by CTL without loss of specificity. These CD8‐enhanced antigens induce greater CD3 ζ chain phosphorylation in cognate CTL leading to substantial increases in cytokine production, proliferation and priming of naive T cells. This effect provides a fundamental new mechanism with which to enhance cellular immunity to specific T cell antigens.
Expression of CTLA‐4 and FOXP3 in cis protects from lethal lymphoproliferative disease
Authors: Chikuma Shunsuke , Bluestone Jeffrey A. 
Published: April 2007

AbstractBoth CTLA‐4‐deficient and FoxP3‐deficient mice exhibit a short life span due to massive lymphoproliferation (LP) and a systemic autoimmune‐like syndrome. Although it has been postulated that both diseases result from regulatory T cell (Treg) defects, there have been no direct complementation studies to elucidate their relationship in homeostatic lymphocyte proliferation during the neonatal period. In this study, reconstitution of sublethally irradiated RAG KO mice with either CTLA‐4‐deficient or FoxP3‐deficient bone marrow (BM) resulted in LP disease similar to that observed in CTLA‐4 KO or Scurfy mice, respectively. Although co‐injection of BM from wild‐type mice inhibited the activation of CTLA‐4‐deficient or FoxP3‐deficient T cells and ameliorated LP disease through extrinsic regulatory mechanisms by Treg cells, mice that had received the BM mixture of Scurfy and CTLA‐4 KO BM eventually died of incomplete protection. These results suggest common attributes of both diseases, but expression of both CTLA‐4 and FoxP3 on the same cell subset is essential to fully prevent LP disease.
Catechol‐Bearing Dipyrazinylpyridine Complexes of Ruthenium(II)
Authors: Al‐mutlaq Fahad A. , Potvin Pierre G. , Philippopoulos Athanassios I. , Falaras Polycarpos 
Published: April 2007

AbstractThe new tridentate ligand 4‐(3,4‐methylenedioxyphenyl)‐2,6‐dipyrazinylpyridine (2) was prepared in good yield in a one‐pot reaction. The RuII complexes [Ru(2)2](PF6)2 and [Ru(1)(2)](PF6)2 [1 is 2,6‐dipyrazinyl‐4‐(4‐tolyl)pyridine] were prepared in good yields and tested as photosensitizers against [Ru(1)2](PF6)2 and [Ru(ttpy)2](PF6)2 [ttpy is 4′‐(4‐tolyl)‐2,2′:6′,2″‐terpyridine]. The photosensitization ability follows the order [Ru(1)2](PF6)2 > [Ru(1)(2)](PF6)2 > [Ru(2)2](PF6)2 >> [Ru(ttpy)2](PF6)2, which is explainable in terms of mechanism and driving force. Hydrolysis of the methylene acetal function affords the catechol‐appended complexes [Ru(3)2](PF6)2 and [Ru(1)(3)](PF6)2 [3 is 4‐(3,4‐dihydroxyphenyl)‐2,6‐dipyrazinylpyridine] in excellent yields. These insoluble, paramagnetic precipitates when tested as photosensitizers in homogeneous solution and in one case adsorbed on titania are able to generate photocurrents in a photovoltaic cell, albeit more weakly compared to the so‐called N719 dye. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
Palm oil markets and future supply
Authors: Carter Claire , Finley Willa , Fry James , Jackson David , Willis Lynn 
Published: April 2007

AbstractThis article considers the recent trends in the palm oil market balance and the future prospects for palm oil fundamentals. The article finds that there exists potential for the demand for palm oil and its products to increase quite steeply, partly due to emerging demand as a relatively cheap biofuel (whether as palm biodiesel or for direct burning), and partly due to its price advantages in edible applications. In terms of supply, as long as there is willingness to plant more area with oil palm in environmentally sensitive areas, there will be continued growth in the oil palm industry. This development is likely to be led primarily by Indonesia with increasing areas planted with oil palm, notably in Kalimantan, and by continued yield improvements in Malaysia.
Ruthenium Complexes of Electronically Coupled Cyclopentadienone Ligands – Catalysts for Transformations of Propargyl Alcohols
Authors: Haak Edgar 
Published: April 2007

AbstractA series of donor‐ and acceptor‐substituted ruthenium cyclopentadienone complexes were synthesized and their catalytic activities towards propargyl alcohols focused on amination reactions have been investigated. It is shown that the substituents of the cyclopentadienone ligand determine the mode of activation of propargyl alcohols by these complexes leading to different central intermediates in catalytic cycles. Catalytic transformations of propargyl alcohols to α‐ or β‐amino ketones, enamino ketones, α,β‐unsaturated imines, ketones, alkenes and conjugated enynes could be achieved. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
CE‐MS of antihistamines using nonvolatile phosphate buffer
Authors: Chien Chiu‐Tang , Li Fu‐An , Huang Ju‐Li , Her Guor‐Rong 
Published: April 2007

AbstractAntihistamines were analyzed by CE‐ESI‐MS using phosphate buffer. The separation was performed in an acidic environment so that phosphate ions had a net velocity flowing toward the inlet reservoir instead of the ESI source. To further reduce the effect of ion suppression, the sodium ion in sodium phosphate was replaced with an ammonium ion. Furthermore, with the combination of reducing the concentration of acid added to the sheath liquid and the use of a low‐flow interface, phosphoric acid could be added to the sheath liquid. Because of the use of the same counterion (phosphate ion) in running buffer and in sheath liquid, the separation integrity (resolution, elution order, and peak shape) was preserved. In addition, ion suppression was also greatly alleviated because a minimal amount of phosphate flowed into the ESI source.
CE – a multifunctional application for clinical diagnosis
Authors: Sniehotta Maike , Schiffer Eric , Zürbig Petra , Novak Jan , Mischak Harald 
Published: April 2007

AbstractCE has been used widely as an analytical tool with high separation power taking advantage of size, charge‐to‐size ratio, or isoelectric point of various analytes. In combination with detection methods, such as UV absorption, electrochemical detection, fluorescence, or mass spectrometry (MS), it allows the separation and detection of inorganic and organic ions, as well as complex compounds, such as polypeptides, nucleic acids, including PCR amplicons from viruses or bacteria. Recent interest in identification of biomarkers of diseases using body fluids leads to development of CE‐MS techniques. These applications allowed identification of new potential biomarkers for clinical diagnosis and monitoring of therapeutic interventions. In this report, we present a technical overview of various CE techniques and discuss their applications in clinical medicine.