bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship-centred care for people living with dementia in care homes. A rapid evidence summary
Authors: Gillen Elizabeth , Edwards Deborah , Roberts Seren , Davies Nia , Davies Isobel , Harden Jane 
Published: April 2024

AbstractDementia is a progressive degenerative disease, typically affecting older adults for which there is currently no cure. Dementia is characterised by progressive impairment to several cognitive functions including memory and orientation, practical abilities and mood changes, all of which can impact personality and social relationships. The theory of social death has been explored for people living with dementia as the ability to maintain social interactions are threatened leading to a loss of social identity and exclusion and withdrawal from the wider community.A relationship-centred care approach has been recommended to improve care for older people in long-term care, aiming to create environments conducive to relationships, considering the needs of the person living with dementia and also the staff and family members involved in their care. The ‘Senses Framework’ by Nolan was designed to promote relationships, acknowledging the experiences of all parties across six senses: security, continuity, belonging, purpose, fulfilment and significance. Utilising the Senses Framework has the potential to sustain meaningful relationships by fostering a sense of value and empowerment.This Rapid Evidence Summary aims to explore the evidence assessing the benefits of a relationship triad approach (Senses Framework and other relationship-centred care approaches) in long term care settings (including care homes) for people living with dementia. Nine primary studies and one systematic review were identified.The benefits of using a relationship-centred approach were mapped under each of the senses described within the Senses Framework, detailed separately for people living with dementia, relatives and care home staff. For people living with dementia, interventions using touch and music increased the sense of security and belonging reducing neuropsychiatric conditions such as agitation and aggression. Memory boxes were used to support a sense of significance and continuity and significant moments from the past brought pleasure and enabled meaningful conversations. For relatives and staff, improved communication and relationships increased confidence and trust and by working together they found that they could exert more influence and could develop into a powerful force for change.
Antihypertensive Medication Adherence and Medical Costs, Health Care Utilization, and Labor Productivity among Persons with Hypertension
Authors: Lee Jun Soo , Escano Raul Segura , Therrien Nicole L. , Kumar Ashutosh , Bhatt Ami , Pollack Lisa M. , Jackson Sandra L. , Luo Feijun 
Published: April 2024

AbstractBackgroundHypertension affects nearly half of U.S. adults, yet remains inadequately controlled in over three-quarters of these cases. This study aims to assess the association between adherence to antihypertensive medications and total medical costs, health care utilization, and productivity-related outcomes.MethodsWe conducted a retrospective cohort study using MarketScan databases, which included individuals aged 18–64 with non-capitated health insurance plans in 2019. Adherence was defined as ≥80% Medication Possession Ratio (MPR) for prescribed antihypertensive medications. We used a generalized linear model to estimate total medical costs, a negative binomial model to estimate health care utilization (emergency department visits and inpatient admissions), an exponential hurdle model to estimate productivity-related outcomes (number of sick absences, short-term disability [STD], long-term disability [LTD]), and a two-part model to estimate productivity-related costs in 2019 U.S. dollars. All models were adjusted for age, sex, urbanicity, census region, and comorbidities. We reported average marginal effects for outcomes related to antihypertensive medication adherence.ResultsAmong 379,503 individuals with hypertension in 2019, 54.4% adhered to antihypertensives. Per-person, antihypertensive medication adherence was associated with $1,441 lower total medical costs, $11 lower sick absence costs, $291 lower STD costs, and $69 lower LTD costs. Per 1,000 individuals, medication adherence was associated with lower healthcare utilization, including 200 fewer ED visits and 90 fewer inpatient admissions, and productivity-related outcomes, including 20 fewer sick absence days and 442 fewer STD days.ConclusionsAdherence to antihypertensives was consistently associated with lower total medical costs, reduced healthcare utilization, and improved productivity-related outcomes.
Potentiation of the M1muscarinic acetylcholine receptor normalizes neuronal activation patterns and improves apnea severity inMecp2+/-mice
Authors: Smith Mackenzie , Dodis Grace E. , Vanderplow Amanda M. , Gonzalez Sonia , Rhee Yewon , Gogliotti Rocco G. 
Published: April 2024

AbstractRett syndrome (RTT) is a neurodevelopmental disorder that is caused by loss-of-function mutations in themethyl-CpG binding protein 2(MeCP2) gene. RTT patients experience a myriad of debilitating symptoms, which include respiratory phenotypes that are often associated with lethality. Our previous work established that expression of the M1muscarinic acetylcholine receptor (mAchR) is decreased in RTT autopsy samples, and that potentiation of the M1receptor improves apneas in a mouse model of RTT; however, the population of neurons driving this rescue is unclear. Loss of Mecp2 correlates with excessive neuronal activity in cardiorespiratory nuclei. Since M1is found on cholinergic interneurons, we hypothesized that M1-potentiating compounds decrease apnea frequency by tempering brainstem hyperactivity. To test this,Mecp2+/-andMecp2+/+mice were screened for apneas before and after administration of the M1positive allosteric modulator (PAM) VU0453595 (VU595). Brains from the same mice were then imaged for c-Fos, ChAT, and Syto16 using whole-brain light-sheet microscopy to establish genotype and drug-dependent activation patterns that could be correlated with VU595’s efficacy on apneas. The vehicle-treatedMecp2+/-brain exhibited broad hyperactivity when coupled with the phenotypic prescreen, which was significantly decreased by administration of VU595, particularly in regions known to modulate the activity of respiratory nuclei (i.e. hippocampus and striatum). Further, the extent of apnea rescue in each mouse showed a significant positive correlation with c-Fos expression in non-cholinergic neurons in the striatum, thalamus, dentate gyrus, and within the cholinergic neurons of the brainstem. These results indicate thatMecp2+/-mice are prone to hyperactivity in brain regions that regulate respiration, which can be normalized through M1potentiation.
OrgaMeas: A pipeline that integrates all the processes of organelle image analysis
Authors: Baba Taiki , Inoue Akimi , Tanimura Susumu , Takeda Kohsuke 
Published: April 2024

AbstractAlthough image analysis has emerged as a key technology in the study of organelle dynamics, the commonly used image-processing methods, such as threshold-based segmentation and manual setting of regions of interests (ROIs), are error-prone and laborious. Here, we present a highly accurate high-throughput image analysis pipeline called OrgaMeas for measuring the morphology and dynamics of organelles. This pipeline mainly consists of two deep learning-based tools: OrgaSegNet and DIC2Cells. OrgaSegNet quantifies many aspects of different organelles by precisely segmenting them. To further process the segmented data at a single-cell level, DIC2Cells automates ROI settings through accurate segmentation of individual cells in differential interference contrast (DIC) images. This pipeline was designed to be low cost and require less coding, to provide an easy-to-use platform. Thus, we believe that OrgaMeas has potential to be readily applied to basic biomedical research, and hopefully to other practical uses such as drug discovery.
KleTy: integrated typing scheme for core genome and plasmids reveals repeated emergence of multi-drug resistant epidemic lineages in Klebsiella worldwide
Authors: Li Heng , Liu Xiao , Li Shengkai , Rong Jie , Xie Shichang , Gao Yuan , Zhong Ling , Jiang Quangui , Jiang Guilai , Ren Yi , Sun Wanping , Hong Yuzhi , Zhou Zhemin 
Published: April 2024

AbstractBackgroundClinically important lineages inKlebsiella, especially those expressing multi-drug resistance (MDR), pose severe threats to public health worldwide. They arose from the co-evolution of the vertically inherited core genome and horizontal gene transfers by plasmids, which has not been systematically explored.ResultsWe designed KleTy, which consists of dedicated typing schemes for both the core genome and plasmids inKlebsiella. We demonstrated the superior performance of KleTy over many state-of-the-art pipelines using both simulated and real data. We used both schemes to genotype 33,272Klebsiellagenomes, categorising them into 1,773 distinct populations and predicting the presence of 87,410 plasmids from 837 clusters (PCs). Notably,Klebsiellais the center of the plasmid-exchange network within Enterobacteriaceae. Our results associated the international emergence of prevalentKlebsiellapopulations with only four carbapenem-resistance (CR) PCs, two hypervirulent PCs, and two hvCR-PCs encoding both carbapenemase and hypervirulence. Furthermore, we observed the ongoing international emergence ofblaNDM, accompanied by the replacement of the previously dominant population,blaKPC-encoding HC1360_8 (CC258), during 2003-2018, with the emergingblaNDM-encoding HC1360_3 (CC147) thereafter. Additionally, expansions of carbapenem-resistantKlebsiella pneumoniae(hvCRKP) were evidenced in both populations, driven by plasmids of MDR-hypervirulence convergences.ConclusionsThe study illuminates how the global genetic landscape ofKlebsiellahas been shaped by the co-evolution of both the core genome and the plasmids, underscoring the importance of surveillance and control of the dissemination of plasmids for curtailing the emergence of hvCRKPs.
Ectopic Reconstitution of a Spine-Apparatus Like Structure Provides Insight into Mechanisms Underlying Its Formation
Authors: Falahati Hanieh , Wu Yumei , De Camilli Pietro 
Published: April 2024

AbstractThe endoplasmic reticulum (ER) is a continuous cellular endomembrane network that displays focal specializations. Most notable examples of such specializations include the spine apparatus of neuronal dendrites, and the cisternal organelle of axonal initial segments. Both organelles exhibit stacks of smooth ER sheets with a narrow lumen and interconnected by a dense protein matrix. The actin-binding protein synaptopodin is required for their formation. Here, we report that expression in non-neuronal cells of a synaptopodin construct targeted to the ER is sufficient to generate stacked ER cisterns resembling the spine apparatus with molecular properties distinct from the surrounding ER. Cisterns within these stacks are connected to each other by an actin-based matrix that contains proteins also found at the spine apparatus of neuronal spines. These findings reveal a critical role of a synaptopodin-dependent actin matrix in generating cis-ternal stacks. These ectopically generated structures provide insight into spine apparatus morphogenesis.
The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube
Authors: Zhang Isabel , Boezio Giulia LM , Cornwall-Scoones Jake , Frith Thomas , Jiang Ming , Howell Michael , Lovell-Badge Robin , Sagner Andreas , Briscoe James , Delás M Joaquina 
Published: April 2024

AbstractThe vertebrate neural tube generates a large diversity of molecularly and functionally distinct neurons and glia from a small progenitor pool. While the role of spatial patterning in organising cell fate specification has been extensively studied, temporal patterning, which controls the timing of cell type generation, is equally important. Here we define a global temporal programme operating in progenitors throughout the vertebrate nervous systems that governs cell fate choices by regulating chromatin accessibility. Perturbation of this cis-regulatory programme affects sequential cell fate transitions in neural progenitors and the identity of their progeny. The temporal programme operates in parallel to spatial patterning, ensuring the timely availability of regulatory elements for spatial determinants to direct cell-type specific gene expression. These findings identify a chronotopic spatiotemporal integration strategy in which a global temporal chromatin programme determines the output of a spatial gene regulatory network resulting in the temporally and spatially ordered allocation of cell type identity.
Moments of nucleon unpolarized, polarized, and transversity parton distribution functions from lattice QCD at the physical point
Authors: Rodekamp Marcel , Engelhardt Michael , Green Jeremy R. , Krieg Stefan , Liuti Simonetta , Meinel Stefan , Negele John W. , Pochinsky Andrew , Syritsyn Sergey 
Published: April 2024

The second Mellin moments ⟨x⟩ of the nucleon’s unpolarized, polarized, and transversity parton distribution functions are computed. Two lattice QCD ensembles at the physical pion mass are used: these were generated using a tree-level Symanzik-improved gauge action and 2+1 flavor tree-level improved Wilson Clover fermions coupling via 2-level HEX-smearing. The moments are extracted from forward matrix elements of local leading twist operators. We determine renomalization factors in RI-(S)MOM and match to MS¯ at scale 2 GeV. Our findings show that operators that exhibit vanishing kinematics at zero momentum can have significantly reduced excited-state contamination. The resulting polarized moment is used to quantify the longitudinal contribution to the quark spin-orbit correlation. All our results agree within two sigma with previous lattice results.

Published by the American Physical Society
2024
Cited by how many? Using Google Scholar for print monograph collection analysis at a small academic library
Authors: Dudash Andrew , Gordon Jacob E. 
Published: April 2024

Purpose
The purpose of this case study was to complement existing weeding and retention criteria beyond the most used methods in academic libraries and to consider citation counts in the identification of important scholarly works.

Design/methodology/approach
Using a small sample of items chosen for withdrawal from a small liberal arts college library, this case study looks at the use of Google Scholar citation counts as a metric for identification of notable monographs in the social sciences and mathematics.

Findings
Google Scholar citation counts are a quick indicator of classic, foundational or discursive monographs in a particular field and should be given more consideration in weeding and retention analysis decisions that impact scholarly collections. Higher citation counts can be an indicator of higher circulation counts.

Originality/value
The authors found little indication in the literature that Google Scholar citation counts are being used as a metric for identification of notable works or for retention of monographs in academic libraries.
Women on boards and ESG performance: empirical evidence before and during the COVID-19 pandemic in Indonesia and Malaysia
Authors: Agustina Rahayu Putri , Barokah Zuni 
Published: April 2024

Purpose
This study aims to investigate whether the presence of women in the boardroom influences companies’ environmental, social and governance (ESG) performance. Furthermore, it examines whether the COVID-19 pandemic and family control affect the relationship.

Design/methodology/approach
This study uses nonfinancial firms listed on the Indonesia and Malaysia Stock Exchange during 2018-2021. Thomson Reuters’ database is used to collect the ESG scores. Using 312 firm-year observations, the authors apply multiple regressions and sensitivity testing to ensure the robustness of the results.

Findings
This study provides empirical evidence that the presence of women in the boardroom improves companies’ ESG and family control weakens the relationship. Meanwhile, there is no support on the moderating effect of the COVID-19 pandemic. The authors also conducted additional tests using ESG pillars (i.e. environment, social and governance pillars) as the dependent variable. The findings are robust to alternative samplings.

Research limitations/implications
This research is limited to Indonesia and Malaysia, thus affecting the generalizability of the results to all developing countries. The sample size is relatively small due to data limitations related to the availability of ESG scores.

Practical implications
The findings of this study provide a basis for the government to establish mandatory regulations regarding sustainability performance. The positive relationship between women on boards and better ESG performance suggests that encouraging gender diversity in corporate leadership can improve sustainability practices. The government may consider implementing gender quota regulations to increase women's representation on corporate boards.

Social implications
Shareholders can pursue investment portfolios in socially responsible companies, prioritizing ESG performance. In addition, investors should consider the presence of women in the company’s boardroom and whether family control exists when making investment decisions.

Originality/value
Overall, the originality and significance of this research lie in its comprehensive examination of the moderating factors, the inclusion of different governance systems in the sample, and the exploration of psychological aspects, contributing to a deeper and more nuanced understanding of the relationship between women on boards and ESG performance in the context of developing countries.
Place branding as rural development policy in China: the case of Guangshan county
Authors: Zhang Yingju , Liu Saimin , Baldi Giovanni 
Published: April 2024

Purpose
This paper aims to explore the rationale, the process and the outcomes and risks of place branding in rural China.

Design/methodology/approach
An in-depth case study analysis, including interviews, has been conducted.

Findings
Place branding in the case of China is practiced and dominated through administrative entities by using subsidies and regional development programs to coordinate, organize and promote local agricultural resources. Although this government-led place branding has effective effects on rural development, it is unsustainable and unstable because it lacks sufficient market and stakeholder participation.

Research limitations/implications
The effectiveness of place branding in China has been examined and proved.

Practical implications
The government’s role in place branding in China should be adjusted. The government should position itself as a service and auxiliary role. Simultaneously, it should strengthen market-oriented operations and stakeholder participation in place branding.

Originality/value
This paper is one of the first contributions to examine the impact of place branding as a rural development policy tool in China, and the in-depth case study examines and proves the effectiveness of place branding in rural China.
Breaking the inequality reproduction circle in the NHS: the importance of senior management team's actions (SMTA)
Authors: Wang Wen , Seifert Roger , Bamber Matthew 
Published: April 2024

PurposeThis study examines potential ways to break the inequality reproduction circle faced by ethnic minority health workers and sustained by key performance indicators (KPIs)-centred management in the National Health Service (NHS) in England. It does so through the lens of signalling theory.Design/methodology/approachThree years panel data for 2018–2020 covering 207 hospitals was compiled from the annual NHS staff survey and matched with relevant administrative records. Structural equation modelling was used to test the proposed hypotheses at the organisational level.FindingsThe moderated mediating model reveals that persistent racial discrimination by managers and coworkers can disadvantage the career progression of ethnic minority health workers, which in turn reinforces and reproduces economic and health inequalities among them. More importantly, we show how the collective agreement that the senior management team acts (SMTA) on staff feedback can break this vicious circle.Research limitations/implicationsWhile our research focuses on the not-for-profit health care sector, it opens important opportunities to extend the proposed model to understand organisational inequality and how to address it.Practical implicationsPerceived SMTA can send strong signals to reduce deep-rooted discrimination (race, gender, age, etc.) through resource allocations and instrumental functions. This is also a way to address the current staff burnout and shortage issues in the healthcare sector.Social implicationsThis article reveals why the purpose of organisations that provide public service to reduce social inequality was comprised during their business-like operations and more importantly, how to reflect their foundational purpose through management practice.Originality/valueThis study offers a way forward to resolve one of the unintended consequences of KPI-centred management in the not-for-profit sector through unpacking the process of inequality reproduction and, more importantly, how it is possible to break this vicious circle.
Impedance control for force tracking of a dual-arm cooperative robot based on particle swarm optimization
Authors: Li Li , Huang Tong , Pan Chujia , Pan J.F. , Su Wenbin 
Published: April 2024

Purpose
The purpose of this paper aims to investigate the adaptive impedance control and its optimized PSO algorithm for force tracking of a dual-arm cooperative robot. Because the dual-arm robot is directly in contact with external environment, controlling the mutual force between robot and external environment is of great importance. Besides, a high compliance of the robot should be guaranteed.

Design/methodology/approach
An impedance control based on Particle Swarm Optimization (PSO) algorithm is designed to track the mutual force and achieve compliance control of the robot end.

Findings
The experimental results show that the impedance control coefficients can be automatically tuned converged by PSO algorithm.

Originality/value
The system can reach a steady state within 0.03 s with overshoot convergence, and the force fluctuation range at the steady state decreases to about ±0.08 N even under the force mutation condition.
Climate consciousness: assessing climate change awareness in Gurugram, India
Authors: Manchanda Rimple 
Published: April 2024

PurposeThe objective of this study is to explore the level of understanding and actions taken by the people of Gurugram (erstwhile Gurgaon) to mitigate the impact of climate change, given its critical importance as a global issue.Design/methodology/approachUsing a qualitative approach, primary data were collected through in-depth interviews by means of semi-structured interview methods.FindingsThe findings indicate that while people are aware of climate change, the information is deficient for them to translate their knowledge into effective action. Some of the major challenges identified are lack of appropriate understanding, resources, education, motivation and government initiatives, as well as the old habits, peer influence, feeling of incapability and limited media exposure. To bridge the intention-action gap, it is recommended that people should be empowered to act desirably. There is a change need for awareness and education on ways to mitigate the effects of climate change. The study has implications for researchers, environmentalists, policymakers, non-government organizations and local residents of Gurugram.Originality/valueThis study provides unique insights into the understanding of climate change by the general public and challenges faced in taking pro-environment actions. It emphasizes the urgent need to create awareness and educate individuals about ways to mitigate the impact of climate change.