bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multiplicative noise induced bistability and stochastic resonance
Authors: Migliorini Giuliano , Fanelli Duccio 
Published: April 2024

Abstract
Stochastic resonance is a well established phenomenon, which proves relevant for a wide range of applications, of broad trans-disciplinary breath. Consider a one dimensional bistable stochastic system, characterized by a deterministic double well potential and shaken by an additive noise source. When subject to an external periodic drive, and for a proper choice of the noise strength, the system swings regularly between the two existing deterministic fixed points, with just one switch for each oscillation of the imposed forcing term. This resonant condition can be exploited to unravel weak periodic signals, otherwise inaccessible to conventional detectors. Here, we will set to revisit the stochastic resonance concept by operating in a modified framework where bistability is induced by the nonlinear nature of the multiplicative noise. A candidate model is in particular introduced which fulfils the above requirements while allowing for analytical progress to be made. Working with reference to this case study, we elaborate on the conditions for the onset of the generalized stochastic resonance mechanism. As a byproduct of the analysis, a novel resonant regime is also identified which displays no lower bound for the frequencies that can be resolved, at variance with the traditional setting.
Efficacy and Safety of Sacubitril/Valsartan in Chronic Type B Aortic Dissection Combined With Mild Hypertension
Authors: Wang Xuelin , Song Feier , Jiang Lujing , Huang Ziling , Luo Songyuan , Li Xin , He Xuyu 
Published: April 2024

Abstract

BACKGROUND
Optimal antihypertensive medication for chronic type B aortic dissection (AD) remains undecided. This study compared the efficacy and safety of sacubitril/valsartan with valsartan to determine suitable antihypertensive drug combinations.

METHODS
In this single-center, open-label, randomized, controlled trial, patients with chronic Stanford type B AD and mild hypertension were randomized to receive sacubitril/valsartan 100/200 mg or valsartan 80/160 mg. The primary endpoint was the reduction in mean sitting systolic blood pressure (msSBP) at week 8 in patients with sacubitril/valsartan vs. valsartan. Key secondary endpoints included changes in (i) mean sitting diastolic blood pressure (msDBP); (ii) pulse pressure (PP); and (iii) mean ambulatory blood pressure (BP) for 24-hour, daytime, and nighttime. Safety assessments included adverse events (AEs) and serious AEs. This trial was registered with the Chinese Clinical Trial Registry, identifier: ChiCTR2300073399.

RESULTS
A total of 315 patients completed the study. Sacubitril/valsartan provided a significantly greater reduction in msSBP than valsartan at week 8 (between-treatment difference: −5.1 mm Hg [95% confidence interval −5.8 to −4.5], P &lt; 0.001). Reductions in msSBP, msDBP, and PP as well as the mean ambulatory BP for 24-hour, daytime, and nighttime, were significantly greater in sacubitril/valsartan compared with valsartan (all P &lt; 0.001). No excessive episodes of AEs occurred in the sacubitril/valsartan group.

CONCLUSIONS
Sacubitril/valsartan and valsartan reduced BP compared with baseline values. However, sacubitril/valsartan improved BP control to a greater extent than valsartan. It may offer a new treatment option for patients with mild hypertension and chronic type B AD.
Pharmacist optimization of lipid therapy in patients with peripheral vascular disease
Authors: Tucker Mary-Ashlyn , Meyer Andrew , Bitonti Michael , Supple Megan , Cain Brandon 
Published: April 2024

Abstract

Purpose
American College of Cardiology/American Heart Association guidelines recommend high-intensity statin therapy and consideration for nonstatin therapy for patients with peripheral vascular disease (PVD); however, utilization rates remain suboptimal. The primary objective of this study was to determine whether pharmacist intervention for patients with PVD could improve the percentage of patients discharged on a high-intensity statin.

Methods
The study used a single-center pre/post design and included patients with PVD who underwent peripheral bypass during their admission. Postintervention patients managed with an order set including a preselected consult for a pharmacy lipid protocol were compared to preintervention patients managed using the order set without the consult. The primary outcome was the percentage of patients discharged on a high-intensity statin. Secondary outcomes included intensification of statin therapy, the addition of ezetimibe, and referral to an outpatient lipid clinic.

Results
A total of 175 patients were included in the analysis, with 94 patients in the preintervention group and 81 patients in the postintervention group. The primary outcome met statistical significance, with an increase in the percentage of patients discharged on a high-intensity statin in the postintervention group (70.4%) compared to the preintervention group (38.3%) (P &lt; 0.001; 95% confidence interval, 1.37-2.46). Secondary outcomes that met statistical significance included an increase in the percentage of patients with any increase in statin intensity (35.8% vs 20.2%; P = 0.02).

Conclusion
The addition of a pharmacist consult led to an increase in the percentage of patients discharged on a high-intensity statin and an increase in overall statin intensification.
Risks and Complications Rate in Liposuction: A Systematic Review and Meta-Analysis
Authors: Comerci Alexander J , Arellano Jose Antonio , Alessandri-Bonetti Mario , Mocharnuk Joseph W , Marangi Giovanni F , Persichetti Paolo , Rubin J Peter , Egro Francesco M 
Published: April 2024

Abstract

Liposuction is a surgical procedure used to remove localized excess adipose tissue. According to The Aesthetic Society's latest annual report, liposuction is the most commonly performed cosmetic procedure. Despite its popularity, the existing literature lacks a unified understanding of the risks associated with liposuction. The aim of this study was to measure complications of liposuction. A systematic review and meta-analysis was reported according to PRISMA guidelines and registered on the PROSPERO database (CRD42023471626). The primary outcome was overall complication rate. The absolute risk for individual complications was also assessed. From 2957 articles, 39 studies were selected for analysis. In total, 29,368 patients were included, with a mean age of 40.62 years and mean BMI of 26.36 kg/m2. Overall, the rate of any complication was 2.62 (95% CI, 1.78-3.84). The most common complication was contour deformity, with a prevalence of 2.35% (95% CI, 1.05%-5.16%). The prevalence of hyperpigmentation was 1.49% (95% CI, 1.12%-1.99%), seroma 0.65% (95% CI, 0.33%-1.24%), hematoma 0.27% (95% CI, 0.12%-0.60%), superficial burn 0.25% (95% CI, 0.17%-0.36%), allergic reaction 0.16% (95% CI, 0.050%-0.52%), skin necrosis 0.046% (95% CI, 0.013%-0.16%), generalized edema 0.041% (95% CI, 0.0051%-0.32%), infection 0.020% (95% CI, 0.010%-0.050%), venous thromboembolism 0.017% (95% CI, 0.0060%-0.053%), and local anesthesia toxicity 0.016% (95% CI, 0.0040%-0.064%). Liposuction is a safe procedure with low complications, of which contour deformity is the most common. Raising awareness of specific risks can enhance surgical outcomes and improve patient-physician understanding.

Level of Evidence: 3
Solubilization and stabilization of lipoic acid trisulfide by creation of various β-cyclodextrin clathrates
Authors: Tomonaga Shoichiro , Ishimaru Hiroaki , Isobe Takahiro , Ohshima Etsuo , Kitagaki Shinji 
Published: April 2024

Abstract
Lipoic acid trisulfide, a sulfane sulfur-containing trisulfide of α-lipoic acid, holds promise in pharmaceuticals, yet knowledge gaps persist regarding its synthesis, properties, and stability. Here, we synthesized the lipoic acid trisulfide with a purity exceeding 99% from α-lipoic acid on a gram scale and obtained novel β-cyclodextrin clathrates (84%-95% yield). Differential scanning calorimetry confirmed the inclusion of lipoic acid trisulfide in β-cyclodextrins. The resulting β-cyclodextrin clathrates exhibited significant improvements in water solubility and thermal stability. This pioneering study demonstrated a novel approach to the practical preparation of trisulfide and its β-cyclodextrin clathrates as active ingredients, paving the way for clinical development.
POCP-nf: an automatic Nextflow pipeline for calculating the percentage of conserved proteins in bacterial taxonomy
Authors: Hölzer Martin 
Published: April 2024

Abstract

Summary
Sequence technology advancements have led to an exponential increase in bacterial genomes, necessitating robust taxonomic classification methods. The Percentage Of Conserved Proteins (POCP), proposed initially by Qin et al. (2014), is a valuable metric for assessing prokaryote genus boundaries. Here, I introduce a computational pipeline for automated POCP calculation, aiming to enhance reproducibility and ease of use in taxonomic studies.

Availability and implementation
The POCP-nf pipeline uses DIAMOND for faster protein alignments, achieving similar sensitivity to BLASTP. The pipeline is implemented in Nextflow with Conda and Docker support and is freely available on GitHub under https://github.com/hoelzer/pocp. The open-source code can be easily adapted for various prokaryotic genome and protein datasets. Detailed documentation and usage instructions are provided in the repository.
Focused stimulation of dorsal versus ventral subthalamic nucleus enhances action–outcome learning in patients with Parkinson’s disease
Authors: Willett Andrew , Wylie Scott A , Bowersock Jessica L , Dawant Benoit M , Rodriguez William , Ugiliweneza Beatrice , Neimat Joseph S , van Wouwe Nelleke C 
Published: April 2024

Abstract
Deep brain stimulation of the subthalamic nucleus is an effective treatment for the clinical motor symptoms of Parkinson’s disease, but may alter the ability to learn contingencies between stimuli, actions and outcomes. We investigated how stimulation of the functional subregions in the subthalamic nucleus (motor and cognitive regions) modulates stimulus–action–outcome learning in Parkinson’s disease patients. Twelve Parkinson’s disease patients with deep brain stimulation of the subthalamic nucleus completed a probabilistic stimulus–action–outcome task while undergoing ventral and dorsal subthalamic nucleus stimulation (within subjects, order counterbalanced). The task orthogonalized action choice and outcome valence, which created four action–outcome learning conditions: action–reward, inhibit–reward, action–punishment avoidance and inhibit–punishment avoidance. We compared the effects of deep brain stimulation on learning rates across these conditions as well as on computed Pavlovian learning biases. Dorsal stimulation was associated with higher overall learning proficiency relative to ventral subthalamic nucleus stimulation. Compared to ventral stimulation, stimulating the dorsal subthalamic nucleus led to a particular advantage in learning to inhibit action to produce desired outcomes (gain reward or avoid punishment) as well as better learning proficiency across all conditions providing reward opportunities. The Pavlovian reward bias was reduced with dorsal relative to ventral subthalamic nucleus stimulation, which was reflected by improved inhibit–reward learning. Our results show that focused stimulation in the dorsal compared to the ventral subthalamic nucleus is relatively more favourable for learning action–outcome contingencies and reduces the Pavlovian bias that could lead to reward-driven behaviour. Considering the effects of deep brain stimulation of the subthalamic nucleus on learning and behaviour could be important when optimizing stimulation parameters to avoid side effects like impulsive reward-driven behaviour.
External magnetic field-driven circularly polarized luminescence and circularly polarized electroluminescence from optically inactive magnesium phthalocyanine luminophore
Authors: Suzuki Seika , Suzuki Daiya , Suzuki Satoko , Shikura Ryuta , Yamamoto Yuta , Yagi Shigeyuki , Imai Yoshitane 
Published: April 2024

Abstract
This article reports that an achiral optically inactive magnesium(II) phthalocyanine with fluorescent emission properties in the near-infrared region emits far-red-to-near-infrared circularly polarized luminescence (far-red-to-NIR-CPL) when photoexcited under an external magnetic field. Furthermore, the development of an external magnetic field-driven circularly polarized electroluminescence (CPEL) device by embedding the luminophore in the emission layer is detailed. The rotational direction of the optically inactive magnesium(II) phthalocyanine-derived CPL and CPEL can be completely controlled by Faraday geometrical inversion of the applied magnetic field.
Anisotropic adhesive interface formed by the spontaneous orientation behavior of liquid crystal polymers
Authors: Kondo Mizuho , Nagata Tatsuki , Hyodo Yukitaka , Okai Daisuke , Adachi Hiroki , Kawatsuki Nobuhiro 
Published: April 2024

Abstract
Adhesive layers were prepared using photoreactive polymer liquid crystals and their application as dismantled adhesives, based on the change in thermal properties associated with photoisomerization, was investigated. Anisotropy in adhesive strength was successfully achieved by controlling the alignment of the liquid crystal using a polyimide alignment film. Furthermore, anisotropy in the adhesive strength due to photoalignment was investigated using the axis-selective photoreactivity of polymer liquid crystals to linearly polarized light.
IBDTransDB: a manually curated transcriptomic database for inflammatory bowel disease
Authors: Avram Victor , Yadav Shweta , Sahasrabudhe Pranav , Chang Dan , Wang Jing 
Published: April 2024

Abstract
Inflammatory Bowel Disease (IBD) therapies are ineffective in at least 40% patients, and transcriptomic datasets have been widely used to reveal the pathogenesis and to identify the novel drug targets for these patients. Although public IBD transcriptomic datasets are available from many web-based tools/databases, due to the unstructured metadata and data description of these public datasets, most of these tools/databases do not allow querying datasets based on multiple keywords (e.g. colon and infliximab). Furthermore, few tools/databases can compare and integrate the datasets from the query results. To fill these gaps, we have developed IBDTransDB (https://abbviegrc.shinyapps.io/ibdtransdb/), a manually curated transcriptomic database for IBD. IBDTransDB includes a manually curated database with 34 transcriptomic datasets (2932 samples, 122 differential comparisons) and a query system supporting 35 keywords from 5 attributes (e.g. tissue and treatment). IBDTransDB also provides three modules for data analyses and integration. IBDExplore allows interactive visualization of differential gene list, pathway enrichment, gene signature and cell deconvolution analyses from a single dataset. IBDCompare supports comparisons of selected genes or pathways from multiple datasets across different conditions. IBDIntegrate performs meta-analysis to prioritize a list of genes/pathways based on user-selected datasets and conditions. Using two case studies related to infliximab treatment, we demonstrated that IBDTransDB provides a unique platform for biologists and clinicians to reveal IBD pathogenesis and identify the novel targets by integrating with other omics data.
Database URL: https://abbviegrc.shinyapps.io/ibdtransdb/
Effects of host plants on spotted lanternfly (Hemiptera: Fulgoridae) nymphal survival and development
Authors: Madalinska Katarzyna , Nielsen Anne L 
Published: April 2024

Abstract
Spotted lanternfly, Lycorma delicatula (White), is an invasive planthopper from China, which was first detected in Berks County, PA, in 2014 and has since spread to adjacent states including New Jersey in 2018. Lycorma delicatula is a polyphagous species that gregariously feeds on over 172 known hosts. We investigated development on key host plants Ailanthus altissima (Miller) (Sapindales: Simaroubaceae), Juglans nigra (L.) (Fagales: Juglandaceae), Acer rubrum (L.) (Sapindales: Sapindaceae), and Vitis vinifera (L.) (Vitales: Vitaceae) for each instar to elucidate potential host use throughout the season and target monitoring efforts. Our study indicated significant differences in survivorship and time spent in each nymphal life stage between host plants. We applied a host suitability index as a function of survivorship and development for each host plant and instar, which indicated A. altissima and J. nigra as suitable hosts for all 4 nymphal instars. Vitis vinifera was highly suitable for first and second instars but had low indices for the third and fourth instars, although suitability of V. vinifera may have varied based on variety and age of the vine. Lycorma delicatula nymphs had the lowest survivorship and longest development time on A. rubrum across all 4 life stages, despite this being a preferred oviposition host. Host had a significant effect on the morphometrics we measured within the first and second instars.
An artificial intelligence–enabled Holter algorithm to identify patients with ventricular tachycardia by analysing their electrocardiogram during sinus rhythm
Authors: Gendelman Sheina , Zvuloni Eran , Oster Julien , Suleiman Mahmoud , Derman Raphaël , Behar Joachim A 
Published: April 2024

Abstract

Aims
Ventricular tachycardia (VT) is a dangerous cardiac arrhythmia that can lead to sudden cardiac death. Early detection and management of VT is thus of high clinical importance. We hypothesize that it is possible to identify patients with VT during sinus rhythm by leveraging a continuous 24 h Holter electrocardiogram and artificial intelligence.

Methods and results
We analysed a retrospective Holter data set from the Rambam Health Care Campus, Haifa, Israel, which included 1773 Holter recordings from 1570 non-VT patients and 52 recordings from 49 VT patients. Morphological and heart rate variability features were engineered from the raw electrocardiogram signal and fed, together with demographical features, to a data-driven model for the task of classifying a patient as either VT or non-VT. The model obtained an area under the receiving operative curve of 0.76 ± 0.07. Feature importance suggested that the proportion of premature ventricular beats and beat-to-beat interval variability was discriminative of VT, while demographic features were not.

Conclusion
This original study demonstrates the feasibility of VT identification from sinus rhythm in Holter.
‘Slavic Irishness’ and the Fluidity of National Identity in Finnegans Wake
Authors: Mccreedy Jonathan 
Published: April 2024

ABSTRACT
This article adopts a sociolinguistic approach to multilingualism within James Joyce’s Finnegans Wake (1939), paying attention to how, in Book 2, Chapter 3, two Irish soldiers called Butt and Taff extensively code-switch into numerous Slavonic languages (for which Bulgarian serves as the focus of this study), and how they do so for the purposes of bonding (through humour) and expressing their complex identities as ‘Slavic Irishmen’. The study looks in depth at the Wake’s extreme levels of multilingualism (with more than 70 languages present within the work) and how a sociolinguistic approach to reading it – one which specifically employs terminology and research drawn from the academic field of sociolinguistics – can provide fresh and intriguing academic perspectives on it. Within this article, I argue that this unique approach may ‘humanize’ Butt and Taff for the reader and that these figures may even be seen to acquire identities akin to ‘real-life’ personas through their use of code-switching. This makes them unlike the ‘avatars’ or ‘siglas’ that critics in Wake studies normally identify in the work.
Multi-omic Analyses Shed Light on The Genetic Control of High-altitude Adaptation in Sheep
Authors: Li Chao , Chen Bingchun , Langda Suo , Pu Peng , Zhu Xiaojia , Zhou Shiwei , Kalds Peter , Zhang Ke , Bhati Meenu , Leonard Alexander , Huang Shuhong , Li Ran , Cuoji Awang , Wang Xiran , Zhu Haolin , Wu Yujiang , Cuomu Renqin , Gui Ba , Li Ming , Wang Yutao , Li Yan , Fang Wenwen , Jia Ting , Pu Tianchun , Pan Xiangyu , Cai Yudong , He Chong , Wang Liming , Jiang Yu , Han Jian-Lin , Chen Yulin , Zhou Ping , Pausch Hubert , Wang Xiaolong 
Published: April 2024

Abstract
Sheep were domesticated in the Fertile Crescent and then spread globally, where they have been encountering various environmental conditions. The Tibetan sheep has adapted to high altitudes on the Qinghai-Tibet Plateau over the past 3000 years. To explore genomic variants associated with high-altitude adaptation in Tibetan sheep, we analyzed Illumina short-reads of 994 whole genomes representing ∼ 60 sheep breeds/populations at varied altitudes, PacBio High fidelity (HiFi) reads of 13 breeds, and 96 transcriptomes from 12 sheep organs. Association testing between the inhabited altitudes and 34,298,967 variants was conducted to investigate the genetic architecture of altitude adaptation. Highly accurate HiFi reads were used to complement the current ovine reference assembly at the most significantly associated β-globin locus and to validate the presence of two haplotypes A and B among 13 sheep breeds. The haplotype A carried two homologous gene clusters: (1) HBE1, HBE2, HBB-like, and HBBC, and (2) HBE1-like, HBE2-like, HBB-like, and HBB; while the haplotype B lacked the first cluster. The high-altitude sheep showed highly frequent or nearly fixed haplotype A, while the low-altitude sheep dominated by haplotype B. We further demonstrated that sheep with haplotype A had an increased hemoglobin–O2 affinity compared with those carrying haplotype B. Another highly associated genomic region contained the EGLN1 gene which showed varied expression between high-altitude and low-altitude sheep. Our results provide evidence that the rapid adaptive evolution of advantageous alleles play an important role in facilitating the environmental adaptation of Tibetan sheep.
Experimental and computational validation of thermal performance of an active greenhouse solar dryer in no-load conditions
Authors: Kumar Lalan , Prakash Om , Ahmad Asim , Salik Md , Pandey Shatrudhan , Hasnain S M Mozammil , Ragab Adham E , Deifalla Ahmed Farouk 
Published: April 2024

Abstract
This study focused on developing a finite element (FE) model using COMSOL Multiphysics to simulate the active mode of a greenhouse dryer under no-load conditions in Ranchi humid subtropical climate. The model visualized the temperature and humidity distribution within the dryer and was validated against real-world experimental results. Under unloaded conditions, the performance assessment revealed a 29.14% efficiency for the proposed dryer and a maximum overall convective heat transfer coefficient of 5.0 W/m2 °C. The internal temperature ranged from 50°C to 70°C, while the relative humidity hovered between 30% and 45%. The COMSOL Multiphysics-based FE model demonstrated close agreement between experimental and predicted results, with minimal statistical error. Overall, the findings suggest that the active mode of the greenhouse dryer could be a valuable tool for crop drying in humid subtropical climates. Additionally, the FE model presents a promising approach for future research and development.