bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vaccination of hormone‐refractory prostate cancer patients with peptide cocktail‐loaded dendritic cells: Results of a phase I clinical trial
Authors: Fuessel Susanne , Meye Axel , Schmitz Marc , Zastrow Stefan , Linné Clemens , Richter Katja , Löbel Barbel , Hakenberg Oliver W. , Hoelig Kristina , Rieber E. Peter , Wirth Manfred P. 
Published: February 2006

AbstractBackgroundImmunotherapies might represent promising alternatives for the treatment of patients with hormone‐refractory prostate cancer (HRPC). In a Phase I clinical trial, we evaluated a vaccination with dendritic cells (DCs) loaded with a cocktail consisting of HLA‐A*0201‐restricted peptides derived from five different prostate cancer‐associated antigens [prostate‐specific antigen (PSA), prostate‐specific membrane antigen (PSMA), survivin, prostein, transient receptor potential p8 (trp‐p8)].METHODSEight HRPC patients received a total of four vaccinations every other week. Clinical and immunological responses were monitored by the determination of the serum PSA levels and by enzyme linked immunospot (ELISPOT) analyses, respectively.RESULTSApart from local skin reactions no side effects were noted. One patient displayed a partial response (PR; PSA decrease >50%) and three other patients showed stable PSA values or decelerated PSA increases. In ELISPOT analyses, three of four PSA responders also showed antigen‐specific CD8+ T‐cell activation against prostein, survivin, and PSMA.CONCLUSIONSThe described protocol represents a safe and feasible concept for the induction of clinical and immunological responses. The application of a peptide cocktail‐derived from different antigens as a novel treatment modality is supposed to allow for the genetic and biologic heterogeneity of PCa. Prostate © 2006 Wiley‐Liss, Inc.
Renin‐angiotensin system is an important factor in hormone refractory prostate cancer
Authors: Uemura Hiroji , Hasumi Hisashi , Ishiguro Hitoshi , Teranishi Jun‐ichi , Miyoshi Yasuhide , Kubota Yoshinobu 
Published: February 2006

AbstractBackgroundThe aim of this study was to perform a comprehensive evaluation of the renin‐angiotensin system (RAS) in prostate cancer.MethodsWe investigated the expression of RAS components in prostate cancer cells treated with hormonal agents. Real‐time PCR data showed the expression of the AT1 receptor, angiotensin I converting enzyme (ACE), and angiotensin I/II (Ang‐I/II) precursor in all 87 prostate tissue samples.ResultsExpression of these genes in hormone refractory prostate cancer (HRPC) was significantly higher than that in normal prostate tissue and untreated prostate cancer tissue. Western blot showed that protein expression of the AT1 receptor and Ang‐I/II was enhanced in LNCaP cells cultivated in steroid‐free medium. When LNCaP cells were stimulated with dihydrotestosterone (DHT), estradiol (E2), dexamethasone (DEX), or anti‐androgen drugs, protein expression of the AT1 receptor and Ang‐I/II was augmented.ConclusionsThe present data suggest that prostatic RAS is overexpressed in HRPC tissue, and expression of its components is influenced by several kinds of hormonal stimulation. Prostate © 2006 Wiley‐Liss, Inc.
Electronic structures of double perovskites Ba2MnMO6 (M = W and Re) from first‐principles studies
Authors: Cheng J. , Yang Z. Q. 
Published: February 2006

AbstractThe electronic structures of double perovskites Ba2MnWO6 and Ba2MnReO6 are studied by using first‐principles linear muffin‐tin orbital method. The ground magnetic phases for the two compounds are found to be antiferromagnetic and ferrimagnetic, respectively, in agreement with experimental results. Barium atoms in both of the compounds show obvious ionic characters while very strong hybridizations are found among the states of Mn 3d–O 2p–W(Re) 5d. Metallic band structure is obtained for Ba2MnReO6 even though on‐site Coulomb interaction (LSDA+U method) is considered for Mn 3d and Re 5d states. A finite energy gap appears in the compound only when spin–orbital coupling on Re ions is also taken into account. This semiconducting band structure can explain well the curve of resistivity versus temperature observed in experiment for ferrimagnetic Ba2MnReO6. (© 2006 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Effect of dielectric screening on the binding energies and diamagnetic susceptibility of a donor in a quantum well wire
Authors: Latha M. , Rajashabala S. , Navaneethakrishnan K. 
Published: February 2006

AbstractThe effect of the dielectric screening on donor binding energies in a quantum wire has been estimated. Since the screening function is shown to be significant in a few phenomena like carrier transport, and not so in a few cases like the donor binding energy calculations, five different screening functions have been used in the calculations to see their relative merits. It is observed that the dielectric function obtained by Resta using the Thomas–Fermi approximation not only gives lower estimates of the ionization energies for all well widths (L ), but also is shown to vary very rapidly with L . The other functions used are those of Hermanson and Vinsome & Richardson. Using the results of the variational calculations for the finite barrier problem, the diamagnetic susceptibility of a donor as a function of L has also been estimated. Though experimental results are not available, we have compared our results for E ion with other theoretical estimates available in the literature. The agreement is found to be good. (© 2006 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Effects of impurities on polaron dynamics in conjugated polymers: Effective potentials
Authors: Lima Matheus Paes , E Silva Geraldo Magela 
Published: February 2006

AbstractWe study the effects of impurities acting on polarons associated with a description of conducting polymers, using a Su–Schrieffer–Heeger‐type Hamiltonian, extended to include an external electric field, Coulomb interactions, and impurities. With the unrestricted time‐dependent Hartree–Fock approximation, we study the interaction between polarons and impurities in conjugated polymers. In polaron dynamics, an impurity acts on a polaron, attracting or repelling it. The character of attraction or repulsion is determined by the polaron charge and the impurity characteristics: donor or acceptor. When we consider a polaron moving on a chain that contains impurities, the polaron can be trapped, passed, or reflected by an impurity. In the present work, the rules that determine the polaron behavior are described by calculating effective potentials due to impurities. Additionally, the case of polarons trapped on impurities is considered. We show that the imprisonment of polarons by impurities could be temporary. © 2006 Wiley Periodicals, Inc. Int J Quantum Chem, 2006
First principles study of 1,2‐dichlorobenzene adsorption on metallic carbon nanotubes
Authors: Fagan Solange B. , Girão E. C. , Filho J. Mendes , Filho A. G. Souza 
Published: February 2006

AbstractA systematic study of the structural and electronic properties of a 1,2‐dichlorobenzene (DCB) molecule interacting with metallic single‐wall carbon nanotubes is reported. The calculations were performed through ab initio methods using the SIESTA code. The interaction between DCB and nanotube is observed to depend on the diameter and it is larger for metallic nanotubes when compared with semiconducting. The binding energies are small thus suggesting that the interaction is through a physisorption process. © 2006 Wiley Periodicals, Inc. Int J Quantum Chem, 2006
On stabilization of nonlinear systems under data rate constraints using output measurements
Authors: De Persis C. 
Published: February 2006

AbstractWe present a contribution to the problem of semi‐global asymptotic stabilization ofnonlinearcontinuous‐time systems underdata rate constraintswhen onlyoutput measurementsare available. We consider systems which are uniformly observable and we point out that the design of an ‘embedded‐observer’ decoder and a controller which semi‐globally stabilize this class of systems under data‐rate constraints requires an appropriate choice of the observer gainandthe data rate. Copyright © 2006 John Wiley & Sons, Ltd.
Velamentous cord insertion into the lower third of the uterus is associated with intrapartum fetal heart rate abnormalities
Authors: Hasegawa J. , Matsuoka R. , Ichizuka K. , Sekizawa A. , Farina A. , Okai T. 
Published: February 2006

AbstractObjectivesTo evaluate the accuracy of sonographic identification of the site of umbilical cord insertion (CI) at 18–20 weeks of gestation, to compare the sensitivities for detection of a velamentous cord insertion (VCI) secondary to a CI into the anterior, posterior or fundal wall, and to compare the intrapartum complications secondary to VCI into the upper, middle or lower third of the uterus.MethodsAs part of the routine ultrasound scan at 18–20 weeks' gestation we evaluated abnormal CI (VCI and marginal CI) and the location of the CI in the uterus in 3446 pregnancies. In cases of abnormal CI, the location of the CI was further classified as being in the upper, middle or lower third of the uterus. After delivery, the placenta and the umbilical cord were examined and intrapartum complications were compared with the location of the CI.ResultsThe values for antenatal detection of VCI were: sensitivity, 25 of 40 (62.5%); positive predictive value, 25 of 25 (100%); and negative predictive value, 3406 of 3421 (99.6%). The sensitivity for cases in which the CI was located on the anterior wall was 12 of 13 (92.3%); when it was located on the posterior wall, the sensitivity was 11 of 22 (50.0%); and when it was fundal the sensitivity was 2 of 5 (40.0%). Variable decelerations were frequently observed with a VCI. In lower VCI cases, non‐reassuring fetal heart rate patterns and emergency Cesarean sections occurred with a higher frequency than in cases with upper or middle VCI (P < 0.01). After delivery, the length of the aberrant vessels in cases of VCI by pathologic examination was 3.9 ± 3.3 cm in the upper third, 4.7 ± 4.6 cm in the middle third, and 10.6 ± 6.8 cm in the lower third; thus, the aberrant vessel length was significantly greater when the CI was in the lower third of the uterus (P = 0.024).ConclusionWe have demonstrated that VCI with a lower CI site and with longer aberrant vessels is associated with various intrapartum complications. This finding has the potential for improving perinatal outcome. Copyright © 2006 ISUOG. Published by John Wiley & Sons, Ltd.
Intermittent non‐ketotic dicarboxylic aciduria in two siblings with hypoglycaemia: An apparent defect in β‐oxidation of fatty acids
Authors: Naylor E. W. , Mosovich L. L. , Guthrie R. , Evans J. E. , Tieckelmann H. 
Published: February 2006

AbstractTwo siblings with intermittent hypoglycaemia, lethargy and coma associated with fatty infiltration of the liver are reported. Urine contained C6 to C14‐dicarboxylic acids.
Argininosuccinic acid synthetase deficiency in a hamster cell line and its complementation of argininosuccinic aciduria human fibroblasts
Authors: González‐Noriega A. , Verduzco J. , Prieto E. , Velázquez A. 
Published: February 2006

AbstractUnlike normal human cells, cultured fibroblasts from patients with argininosuccinic aciduria cannot synthesize arginine from citrulline because they have a deficiency of argininosuccinic acid lyase (ASL). We have found that V79, a Chinese hamster cell line, cannot grow on citrulline. Although these cells show a normal uptake of citrulline and have levels of ASL comparable to a human cell line (HeLa) which can grow in citrulline‐containing medium, V79 cells have less than 5% of the argininosuccinic acid synthetase (ASS) activity of HeLa and cannot convert citrulline to argininosuccinate and thence to arginine. When heterokaryocytes are formed between V79 and a human cell line derived from a patient with ASL deficiency, complementation takes place and citrulline is incorporated into cell protein, presumably after having been converted to arginine. This is the first time that a genetic defect of the urea cycle has been corrected in human cells.
Biochemical studies in a patient with defects in the metabolism of acyl‐CoA and sarcosine: Another possible case of glutaric aciduria type II
Authors: Gregersen N. , Kølvraa S. , Rasmussen K. , Christensen E. , Brandt N. J. , Ebbesen F. , Hansen F. H. 
Published: February 2006

AbstractThe clinical and biochemical abnormalities in a neonate, who died in coma accompanied by severe hypoglycaemia at the age of 3 days, are described. The study of the urinary metabolic profiles of organic acids and amino acids revealed that the excretion rates of glutaric acid, isovaleric acid, isovalerylglycine, 3‐hydroxyisovaleric acid and isobutyric acid were very high. Increased excretion rates were also found for 2‐methylbutyric acid, adipic acid, caproylglycine, 5‐hydroxycaproic acid, caproic acid and butyric acid. The amino acid, sarcosine, was excreted in enhanced amounts and the patient had lactic aciduria, whereas the excretion of 3‐hydroxybutyric acid was only moderately increased. This abnormal excretion pattern is consistent with a defect in the metabolism of acyl‐CoAs and sarcosine. Normal activity of glutaryl‐CoA dehydrogenase was found, excluding glutaryl‐CoA dehydrogenase deficiency (glutaric aciduria type I).
Uptake of lysosomal enzymes by human fibroblasts: Lack of uptake of fungal or plant glycosidases in comparison with a mammalian enzyme
Authors: Dooley K. C. , Applegarth D. A. 
Published: February 2006

Abstractα‐Galactosidase from human placenta was actively taken up by cultured fibroblasts from patients with Fabry's disease whereas the enzyme from the fig was not absorbed. α‐Glucosidase from two microbiological sources,A. fumigatus andA. niger, was not taken up by cultured fibroblasts from patients with Pompe's disease.
Oxygen isotope composition of annually banded modern and mid-Holocene travertine and evidence of paleomonsoon floods, Grand Canyon, Arizona, USA
Authors: O'Brien Gary R. , Kaufman Darrell S. , Sharp Warren D. , Atudorei Viorel , Parnell Roderic A. , Crossey Laura J. 
Published: February 2006

AbstractHolocene and modern travertine formed in spring-fed Havasu Creek of the Grand Canyon, Arizona, was studied to determine the factors governing its oxygen-isotope composition. Analysis of substrate-grown travertine indicates that calculated calcite-formation temperatures compare favorably with measured water temperatures, and include silt-rich laminae deposited by monsoon-driven floods. Ancient spring-pool travertine is dated by U-series at 7380 ± 110 yr and consists of 14 travertine-silt couplets of probable annual deposition. One hundred eighty high-resolution δ18O analyses of this mid-Holocene sample average −11.0‰ PDB. The average value for modern travertine is ∼0.5‰ lower, perhaps because mid-Holocene temperature was higher or there was proportionally greater summer recharge. δ18O cyclicity in the mid-Holocene travertine has average amplitude of 1.9 ± 0.5‰ PDB, slightly less than the inferred modern-day annual temperature range of Havasu Creek. The annual temperature range might have been reduced during the 14-yr interval compared to present, although other non-temperature factors could account for the muted annual variation. Silt-rich laminae within isotopically lower calcite in the modern and mid-Holocene travertine verifies the seasonal resolution of both samples, and suggests that similar temperature-precipitation conditions, as well as monsoon-generated summer floods, prevailed in the mid-Holocene as they do throughout the Grand Canyon region today.
Episodic Late Holocene dune movements on the sand-sheet area, Great Sand Dunes National Park and Preserve, San Luis Valley, Colorado, USA
Authors: Forman S.L. , Spaeth M. , Marín L. , Pierson J. , Gómez J. , Bunch F. , Valdez A. 
Published: February 2006

AbstractThe Great Sand Dunes National Park and Preserve (GSDNPP) in the San Luis Valley, Colorado, contains a variety of eolian landforms that reflect Holocene drought variability. The most spectacular is a dune mass banked against the Sangre de Cristo Mountains, which is fronted by an extensive sand sheet with stabilized parabolic dunes. Stratigraphic exposures of parabolic dunes and associated luminescence dating of quartz grains by single-aliquot regeneration (SAR) protocols indicate eolian deposition of unknown magnitude occurred ca. 1290–940, 715 ± 80, 320 ± 30, and 200–120 yr ago and in the 20th century. There are 11 drought intervals inferred from the tree-ring record in the past 1300 yr at GSDNPP potentially associated with dune movement, though only five eolian depositional events are currently recognized in the stratigraphic record. There is evidence for eolian transport associated with dune movement in the 13th century, which may coincide with the “Great Drought”, a 26-yr-long dry interval identified in the tree ring record, and associated with migration of Anasazi people from the Four Corners areas to wetter areas in southern New Mexico. This nascent chronology indicates that the transport of eolian sand across San Luis Valley was episodic in the late Holocene with appreciable dune migration in the 8th, 10–13th, and 19th centuries, which ultimately nourished the dune mass against the Sangre de Cristo Mountains.
Late Quaternary paleosols, stratigraphy and landscape evolution in the Northern Pampa, Argentina
Authors: Kemp Rob A. , Zárate Marcelo , Toms Phillip , King Matthew , Sanabria Jorge , Arguello Graciella 
Published: February 2006

AbstractThe field properties, micromorphology, grain-size, geochemistry, and optically stimulated luminescence (OSL) ages of two late Quaternary sections have been used to reconstruct the sequence of pedosedimentary processes and to provide insights into landscape evolution in part of the Northern Pampa of Argentina. Paleosols developed in paludal sediments adjacent to the Paraná river at Baradero and in loess at Lozada can both be correlated and linked to other sites, thus enabling for the first time the tentative recognition and tracing of a diachronous soil stratigraphic unit that probably spans the equivalent of at least part of marine oxygen isotope stage (OIS) 5. The paleosol at Lozada was truncated and buried beneath fluvial sediments during the time span of OIS 4 and 3. Eolian gradually replaced paludal inputs at Baradero over this period, and there were also two clearly defined breaks in sedimentation and development of paleosols. The period corresponding to OIS 2 was marked by significant loess accumulation at both sites with accretion continuing into the mid-Holocene only at Lozada. The more developed nature of the surface soil at Baradero probably reflects a combination of a moister climate and a longer soil-forming interval.
Incidence of complementary therapy use in patients undergoing vestibular assessment
Authors: Baguley David M , Humphriss Rachel L , Butler Katy , Knight Richard , Dawson Lisa , Vickers Fiona , Mitchell Alice 
Published: February 2006

Objectives: To determine the incidence of use of complementary therapies in patients with vestibular symptoms undergoing vestibular assessment.Design: A prospective, questionnaire-based study.Setting: A UK university hospital department of audiology with secondary and tertiary referrals.Participants: A consecutive series of 80 patients seen for vestibular assessment between November 2004 and May 2005.Main outcome measures: Use of complementary therapies; actual therapies used and patients' subjective opinion of efficacy.Results: Thirteen patients (16 per cent) had tried some form of complementary therapy for their vestibular symptoms. Ginkgo biloba and acupuncture were the two most popular treatments. Seven patients made their decision as to which treatment to try on the basis of personal recommendation. Six of the 13 patients (46 per cent) reported that their choice of treatment(s) helped them.Conclusions: Sixteen per cent of patients seen for vestibular assessment had tried some form of complementary therapy for their vestibular symptoms. Clinicians should be aware of this and of the potential interactions between complementary therapies and conventional medicine.
Dialogue act recognition under uncertainty using Bayesian networks
Authors: KEIZER SIMON , AKKER RIEKS OP DEN 
Published: February 2006

AbstractIn this paper we discuss the task of dialogue act recognition as a part of interpreting user utterances in context. To deal with the uncertainty that is inherent in natural language processing in general and dialogue act recognition in particular we use machine learning techniques to train classifiers from corpus data. These classifiers make use of both lexical features of the (Dutch) keyboard-typed utterances in the corpus used, and context features in the form of dialogue acts of previous utterances. In particular, we consider probabilistic models in the form of Bayesian networks to be proposed as a more general framework for dealing with uncertainty in the dialogue modelling process.
Including lameness and mastitis in a profit index for dairy cattle
Authors: Stott A. W. , Coffey M. P. , Brotherstone S. 
Published: February 2006

The objective of this work was to establish economic values (EVs) of mastitis and lameness in order to enhance the current UK dairy profit index (£PLI) by including these health traits. The EVs of traits currently in £PLI were also re-evaluated to account for changes in costs/returns over time and to determine their sensitivity to changes in some of the basic assumptions used in their derivation.Predicted transmitting abilities (PTAs) for mastitis are not available in the UK. Instead, PTAs for somatic cell count (SCC), which has a strong genetic correlation with clinical mastitis, were used to predict clinical mastitis. Similarly, PTAs for locomotion and (for bulls with no locomotion PTA) the ‘legs and feet’ composite were used to predict lameness.The EV of mastitis was estimated at £0·83 per percent incidence, giving an index weight for SCC PTA of £0·20. The EV of lameness was estimated at £0·99 per percent incidence, giving an index weight for locomotion PTA of £1·28. The associated index weight for the ‘legs and feet’ composite was estimated to be £1·50. Economic values for all traits (production, lifespan, mastitis and lameness) were found to be sensitive to their associated price assumption but not to price assumptions of other traits in the index or to other production parameters in the model.Better information is needed on the influence of cow age (parity) on incidence of disease and on the probability of involuntary culling to determine the appropriate balance between the EVs for longevity and health. Currently, 16% of the weight in £PLI is attributable to non-production traits. In our revised index this weight increased to 23%. Even so, selection using this index is still predicted to result in an increase in mastitis and lameness, albeit at a very low rate. This situation may be changed by the introduction of fertility into £PLI and through better information about health traits. Incorporation of consumer preference into £PLI may require traits associated with health and welfare of the cow to receive more weight than their EV would suggest in order to maintain or improve health traits in national selection programmes.