bluuebunny/crossref_metadata_2025_split huggingface dataset:
Voice quality after CO2 laser cordectomy—What can we really expect?
Authors: Vilaseca Isabel , Huerta Paula , Blanch José Luis , Fernández‐Planas Ana María , Jiménez Conchita , Bernal‐Sprekelsen Manuel 
Published: July 2007

AbstractBackground.Endoscopic management of laryngeal carcinoma has gained popularity among laryngologists based on the good oncologic and functional results. We evaluated the voice quality after laser cordectomy for early glottic cancer in a variety of vocal situations and its relation with the extension of resection and the age.Methods.We conducted a cross‐sectional study of voice quality in 42 consecutive male patients treated for T1 glottic carcinoma with laser cordectomy. Patients were compared with 21 controls. Voice quality was self‐assessed by the patients. Perceptual analysis was done by a speech pathologist on a running speech sample [GRBAS (grade, roughness, breathiness, asthenicity, strain)]. Acoustic analysis included fundamental frequency (F0), jitter, shimmer, noise to harmonic ratio (N/H), and maximum phonation time (MPT) on the sustained vowels /a/ and /i/, and on various running speech voice samples.Results.Distribution of the patients included in the study by T classification was as follows: Tis, n = 2 (4.8%); T1a, n = 35 (83.3%); and T1b, n = 5 (11.9%). Cordectomy types were: (I), 14%; (II), 26%; (III), 21%; and (V), 38%. Voice improved in almost 60% of patients, returning to normal in 45%. GRBAS showed significant differences between patients and controls and correlated with type of cordectomy. Acoustic analysis showed significant differences in F0, and jitter, with smaller differences in shimmer, N/H, and MPT.Conclusion.Voice quality after laser cordectomy differs from controls, but improves in a majority of patients after the surgery, with almost 50% of patients with subjective normal or near normal voice. Voice quality depends on type of cordectomy. © 2007 Wiley Periodicals, Inc. Head Neck, 2008
Reactions of Polycyclic Ketones with Dimethoxycarbene; a Convenient Route for a ‘One‐Pot’ Preparation of Some α‐Hydroxycarboxylic Acid Esters
Authors: Romański Jarosław , Mlostoń Grzegorz , Heimgartner Heinz 
Published: July 2007

AbstractPolycyclic ‘cage’ ketones, such as pentacyclo[5.4.0.02,6.03,10.05,9]undecan‐8‐one (10), pentacyclo[5.4.0.02,6.03,10.05,9]undecane‐8,11‐dione (11), and adamantan‐2‐one (16) were treated with the nucleophilic dimethoxycarbene (DMC; 1), which was generated thermally from 2,5‐dihydro‐2,2‐dimethoxy‐5,5‐dimethyl‐1,3,4‐oxadiazole (4a) in boiling toluene. In this ‘one‐pot’ procedure, the α‐hydroxycarboxylic acid ester 12 or a corresponding derivative 15 or 17 was obtained (Schemes 4–7). Additionally, ‘cage’ thione 21 was treated with DMC under the same conditions yielding dimethoxythiirane 22 (Scheme 8). Subsequent hydrolysis or desulfurization (followed by hydrolysis on silica gel) of 22 gave α‐mercaptocarboxylate 25 and the corresponding desulfurized ester 24, respectively. In all cases, the addition of DMC occurred stereoselectively, and the addition from the exo‐face is postulated to explain the structures of the isolated products.
An Efficient Synthesis of a Potential (−)‐Reserpine Intermediate from (−)‐Shikimic Acid of the Chiral Pool
Authors: Huang Jian , Chen Fen‐Er 
Published: July 2007

AbstractA highly stereoselective route to the polysubstituted chiral octahydrobenzofuran 12, a potential synthon for the E‐ring core in the (−)‐reserpine synthesis, is described. The α‐bromo acetal 11 was obtained from inexpensive (−)‐shikimic acid (3) through a series of highly stereoselective chemical reactions (Scheme). Et3B/Bu3SnH‐Mediated intramolecular radical cyclization of 11 led to compound 12 with the required configuration.
Four New Briarane Diterpenoids from the Gorgonian Coral Junceella fragilis
Authors: Shen Ya‐Ching , Chen Yu‐Hui , Hwang Tsong‐Long , Guh Jih‐Hwa , Khalil Ashraf Taha 
Published: July 2007

AbstractChemical investigation of the gorgonian coral Junceella fragilis, collected by scuba diving in Taiwan, resulted in the isolation of four new briarane‐type diterpenoids, frajunolides A–D (1–4), along with three known briaranes. Their structures were elucidated on the basis of spectroscopic studies, especially 1‐ and 2D‐NMR as well as HR‐MS experiments. The inhibitory effect of all isolated metabolites towards superoxide‐anion generation and elastase release by human neutrophils in response to formylmethionyl‐leucyl‐phenylalanine/dihydrocytochalasin B (FMLP/CB) was evaluated.
Four New Schisanartane‐Type Nortriterpenoids from Schisandra propinqua var. propinqua
Authors: Lei Chun , Huang Sheng‐Xiong , Chen Ji‐Jun , Pu Jian‐Xin , Li Li‐Mei , Xiao Wei‐Lie , Liu Jin‐Ping , Yang Li‐Bin , Sun Han‐Dong 
Published: July 2007

AbstractFour new, highly oxygenated nortriterpenoids with the unique schisanartane skeleton, propindilactones A–D (1–4), were isolated from the aerial parts of Schisandra propinqua var. propinqua, together with four known schisanartane‐type compounds. The structures of the new plant constituents were established on the basis of extensive spectroscopic methods.
The use of remotely sensed land cover to derive floodplain friction coefficients for flood inundation modelling
Authors: Wilson M. D. , Atkinson P. M. 
Published: July 2007

AbstractRemotely sensed land cover was used to generate spatially‐distributed friction coefficients for use in a two‐dimensional model of flood inundation. Such models are at the forefront of research into the prediction of river flooding. Standard practice, however, is to use single (static) friction coefficients on both the channel and floodplain, which are varied in a calibration procedure to provide a “best fit” to a known inundation extent. Spatially‐distributed friction provides a physically grounded estimate of friction that does not require fitting to a known inundation extent, but which can be fitted if desired. Remote sensing offers the opportunity to map these friction coefficients relatively straightforwardly and for low cost. Inundation was predicted using the LISFLOOD‐FP model for a reach on the River Nene, UK. Friction coefficients were produced from land cover predicted from Landsat TM imagery using both ML and fuzzy c‐means classifiction. The elevetion data used were from combined contour and differential global positioning system (GPS) elevation data. Predicted inundation using spatially‐distributed and static friction were compared. Spatially‐distributed friction had the greatest effect on the timing of flood inundation, but a small effect on predicted inundation extent. The results indicate that spatially‐distributed friction should be considered where the timing of initial flooding (e.g. for early warning) is important. Copyright © 2007 John Wiley & Sons, Ltd.
Analysis of geomorphologic and hydrological characteristics in watershed saturated areas using topographic‐index threshold and geomorphology‐based runoff model
Authors: Chang Chin‐Hsin , Lee Kwan Tun 
Published: July 2007

AbstractThe objective of this paper is to investigate the variation of geomorphology and runoff characteristics in saturated areas under different partial contributing area (PCA) conditions. Geomorphologic information and hydrologic records from two mid‐size watersheds in northern Taiwan were selected for analysis. The PCA ratio in the watershed during a storm was assumed equal to the ratio of the surface‐flow volume to the direct runoff volume from measured hydrologic data. The extents of PCA regions were then determined by using a topographic‐index threshold. Consequently, the geomorphologic factors in saturated and unsaturated areas could be calculated using a digital elevation model, and these factors could then be linked to a geomorphology‐based IUH model for runoff simulation, which can consider both the surface‐ and subsurface‐flow processes in saturated and unsaturated areas, respectively. The results show that geomorphologic characteristics in the saturated areas vary significantly with different PCA ratios especially for higher order streams. A large PCA ratio results in a sharp hydrograph because the quick surface flow dominates the runoff process, whereas the hydrologic response in a low PCA case is dominated by the delayed subsurface flow. Copyright © 2007 John Wiley & Sons, Ltd.
Bactericidal activity of chlorine‐loaded carbide‐derived carbon against Escherichia coli and Bacillus anthracis
Authors: Gogotsi Yury , Dash Ranjan Kumar , Yushin Gleb , Carroll Beth E. , Altork Susan Rachel , Sassi‐Gaha Sihem , Rest Richard F. 
Published: July 2007

AbstractThe authors investigated the bactericidal activity of high‐chlorine‐content nanoporous carbide‐derived carbon (CDC) against the Gram‐positive, spore‐forming bacterium Bacillus anthracis and the common Gram‐negative enteric bacterium Escherichia coli. Chlorine‐loaded nanoporous CDC produced by thermochemical etching of metals and metalloids by chlorination of carbides can retain up to 40 wt % of chlorine. Etching temperature and the structure and composition of carbides allow tuning the porosity of CDC. The CDC chlorine content depends on the synthesis temperature, pore size, and metal carbide used during preparation. It was observed that chlorine‐loaded CDC killed up to 100% of exposed E. coli and B. anthracis spores and vegetative cells in a dose and time‐dependent manner. CDC containing higher concentrations of chlorine killed bacteria to a greater extent and faster than did CDC containing lesser concentrations of chlorine. The results suggest that chlorine‐loaded CDC can be used inseveral commercial, defense, and industrial activities andprocesses to kill bacteria. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2008
Surface modification of medical‐grade polyurethane by cyanurchloride‐activated tetraether lipid (a new approach for bacterial antiadhesion)
Authors: Sateesh Ananthu , Vogel Jürgen , Dayss Evelyn , Fricke Beate , Dölling Karin , Rothe Ulrich 
Published: July 2007

AbstractThe surface of high‐grade medical polyurethane was chemically modified and coated with tetraether lipid, employing cyanurchloride as coupling agent. The surfaces were initially grafted with hexamethylene diisocyanate and subsequently treated with water or hexamethylene diamine to generate free amino groups on the surface. This provides a convenient way for covalent coupling of tetraether lipids. These lipid‐coated surfaces were investigated for bacterial adhesion using Pseudomonas aeruginosa. All lipid‐coated surfaces significantly reduced bacterial adhesion. Surface topology and individual modification steps were controlled by contact angle measurements, attenuated total reflectance infrared spectroscopy, X‐ray photoelectron spectroscopy, confocal laser scanning microscopy, and environmental scanning electron microscopy. This new surface modification approach may reduce the adhesion of bacteria on biomaterials. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2008
Microstructural features in fractured high nitrogen stainless steel hip prostheses: A retrieval study of polished, tapered femoral stems
Authors: Swarts Eric , Kop Alan , Jones Noel , Keogh Cathie , Miller Susan , Yates Piers 
Published: July 2007

AbstractSix fractured high nitrogen stainless steel (HNSS), polished, tapered hip stems have been reviewed for analysis. Clinical data suggests that poor proximal support (loosening), varus positioning, and canal morphology are implicated in the failure of these stems. Metallurgical assessment reveals a number of microstructural deficiencies contributing to failure. Of significance is poor grain homogeneity and larger grain size near the surface of the fractured stems. It appears some polished, tapered HNSS stems are at risk when combinations of these clinical and metallurgical features occur. As the control of grain size, microstructural uniformity, and inclusion content are critical for optimum mechanical performance, it is important the manufacturers review processing methods to further minimize the risk of component failure. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res 84A: 753–760, 2008
Monitoring the quality of innovation processes and innovation successes
Authors: Vrakking Willem J. , Cozijnsen Anton J. 
Published: July 2007

AbstractOrganizations that want to survive in an increasingly demanding situation are forced into continuous innovation of their products, services and production processes. Safeguarding the quality of innovation processes is a prerequisite for quality improvement. In this article, the authors present the main insights required for effective and successful innovation in practice. Key concepts are ‘planning’ and ‘control’. They discuss planning concepts, integral innovation and the issue of simple or complex innovations; they outline a step‐by‐step plan to help achieve a systematic approach to innovation management; finally, they focus on the importance of monitoring the entire innovation process and innovation progression effectively. All of this should result in a quality guarantee of successful innovation.
A contingency view of strategy choice problems: Experiences of Swedish companies in Germany
Authors: Pehrsson Anders 
Published: July 2007

AbstractThe contingency view of business strategy has become popular in research. Differences in strategy problems between companies mainly offering separate products and systems of products are, however, less understood. This article presents an exploratory empirical study that seeks differences between the company categories. Using a cross‐sectional methodological approach and multivariate analysis, the study focuses on Swedish subsidiaries in Germany. The companies offer metal goods, machines and electrotechnical products. According to the results of the study, choices of product qualities are more complex for ‘system’ companies. The balance between customization of a system and standardization in order to reach reproducibility is a dominating problem for this company category. ‘Product’ companies in general are more exposed to price competition, which means that choice of cost levels is representative of a strategy choice problem for this category.
Planned change and organizational success
Authors: Nutt Paul C. 
Published: July 2007

AbstractPlanning identifies activities that create possibilities and change indicates the steps taken to implement a preferred plan. Recognizing the interdependency of of planning and changes is essential. In successful organizations, these activities are merged into a process that is managed by someone with authority. This paper discusses the benefits of ‘planned change’ and the difficulties that arise during planned change. Cases are used to illustrate essential steps in a successful planned change effort.
Taphonomy and zooarchaeology of the Upper Palaeolithic cave of Dzudzuana, Republic of Georgia
Authors: Bar‐Oz G. , Belfer‐Cohen A. , Meshveliani T. , Djakeli N. , Bar‐Yosef O. 
Published: July 2007

AbstractWe present the results of a detailed taphonomic and zooarchaeological study of the faunal remains from the Upper Palaeolithic layers of Dzudzuana Cave, Republic of Georgia. This study presents the first carefully analysed Upper Palaeolithic faunal assemblage from the southern Caucasus and thus serves as a significant point of reference for inter‐regional studies of Upper Palaeolithic subsistence in Eurasia. A series of intra‐site taphonomic comparisons are employed to reconstruct the depositional history of the bone assemblages within the different occupational phases at the site and to investigate subsistence, meat procurement and bone‐processing strategies. Caucasian tur (Capra caucasica), aurochs (Bos primigenius) and steppe bison (Bison priscus) were the major prey species throughout the Upper Palaeolithic. Their frequencies do not change significantly over time, and nor does bone preservation vary by layer. The assemblage is characterised by significant density‐mediated biases, caused by both human bone‐processing behaviours andin situpost‐burial bone attrition. Bone marrow extraction produced large numbers of unidentified bone fragments, many exhibiting green bone fractures. The density and size of bone assemblages and the extent of fragmentation indicate that Dzudzuana Cave was repeatedly occupied by Upper Palaeolithic foragers over many years. Skeletal part representation and butchery marks from all stages of carcass processing suggest that prey occasionally underwent field butchery. Intra‐site taphonomic comparisons highlight uniform patterns of cultural and economic behaviours related to food procurement and processing strategies. Copyright © 2007 John Wiley & Sons, Ltd.
Bailey‐Boushay House: Passion, politics, and the art of public‐private fundraising
Authors: Silha Stephen 
Published: July 2007

AbstractRaising $7.8 million to build a controversial AIDS nursing facility in less than five years took an extraordinary mix of the right personalities, fortuitous timing, grass–roots support, crackerjack lawyers and grant proposal writers, connections with the business and political communities, carefully planned groundwork, and passion.
In pursuit of major gifts: Nondevelopment personnel in fundraising
Authors: Winfree Walter R. “Win” 
Published: July 2007

AbstractA study of the effective utilization of the president, trustees, private citizens, and staff and faculty in the solicitation of major gifts is presented here. In different steps of the major‐gift process, the relative importance of each of these four groups was found to change; moreover, these groups were influential with major‐gift donor prospects both for the same and for different reasons.
Protein‐inhibitor flexible docking by a multicanonical sampling: Native complex structure with the lowest free energy and a free‐energy barrier distinguishing the native complex from the others
Authors: Kamiya Narutoshi , Yonezawa Yasushige , Nakamura Haruki , Higo Junichi 
Published: July 2007

AbstractFlexible docking between a protein (lysozyme) and an inhibitor (tri‐N‐acetyl‐D‐glucosamine, tri‐NAG) was carried out by an enhanced conformational sampling method, multicanonical molecular dynamics simulation. We used a flexible all‐atom model to express lysozyme, tri‐NAG, and water molecules surrounding the two bio‐molecules. The advantages of this sampling method are as follows: the conformation of system is widely sampled without trapping at energy minima, a thermally equilibrated conformational ensemble at an arbitrary temperature can be reconstructed from the simulation trajectory, and the thermodynamic weight can be assigned to each sampled conformation. During the simulation, exchanges between the binding and free (i.e., unbinding) states of the protein and the inhibitor were repeatedly observed. The conformational ensemble reconstructed at 300 K involved various conformational clusters. The main outcome of the current study is that the most populated conformational cluster (i.e., the cluster of the lowest free energy) was assigned to the native complex structure (i.e., the X‐ray complex structure). The simulation also produced non‐native complex structures, where the protein and the inhibitor bound with different modes from that of the native complex structure, as well as the unbinding structures. A free‐energy barrier (i.e., activation free energy) was clearly detected between the native complex structures and the other structures. The thermal fluctuations of tri‐NAG in the lowest free‐energy complex correlated well with the X‐ray B‐factors of tri‐NAG in the X‐ray complex structure. The existence of the free‐energy barrier ensures that the lowest free‐energy structure can be discriminated naturally from the other structures. In other words, the multicanonical molecular dynamics simulation can predict the native complex structure without any empirical objective function. The current study also manifested that the flexible all‐atom model and the physico‐chemically defined atomic‐level force field can reproduce the native complex structure. A drawback of the current method is that it requires a time consuming computation due to the exhaustive conformational sampling. We discussed a possibility for combining the current method with conventional docking methods. Proteins 2008. © 2007 Wiley‐Liss, Inc.
Identifying novel peroxisomal proteins
Authors: Hawkins John , Mahony Donna , Maetschke Stefan , Wakabayashi Mark , Teasdale Rohan D. , Bodén Mikael 
Published: July 2007

AbstractPeroxisomes are small subcellular compartments responsible for a range of essential metabolic processes. Efforts in predicting peroxisomal protein import are challenged by species variation and sparse sequence data sets with experimentally confirmed localization.We present a predictor of peroxisomal import based on the presence of the dominant peroxisomal targeting signal one (PTS1), a seemingly wellconserved but highly unspecific motif. The signal appears to rely on subtle dependencies with the preceding residues. We evaluate prediction accuracies against two alternative predictor services, PEROXIP and the PTS1 PREDICTOR. We test the integrity of prediction on a range of prokaryotic and eukaryotic proteomes lacking peroxisomes. Similarly we test the accuracy on peroxisomal proteins known to not overlap with training data. The model identified a number of proteins within the RIKEN IPS7 mouse protein dataset as potentially novel peroxisomal proteins. Three were confirmedin vitrousing immunofluorescent detection of myc‐epitope‐tagged proteins in transiently transfected BHK‐21 cells (Dhrs2, Serhl, and Ehhadh).The final model has a superior specificity to both alternatives, and an accuracy better than PEROXIP and on par with PTS1 PREDICTOR. Thus, the model we present should prove invaluable for labeling PTS1 targeted proteins with high confidence. We use the predictor to screen several additional eukaryotic genomes to revise previously estimated numbers of peroxisomal proteins. Available athttp://pprowler.itee.uq.edu.au. Proteins 2007. © 2007 Wiley‐Liss, Inc.
Investigating the structural stability of the Tup1‐interaction domain of Ssn6: Evidence for a conformational change on the complex
Authors: Palaiomylitou Maria , Tartas Athanassios , Vlachakis Dimitrios , Tzamarias Dimitris , Vlassi Metaxia 
Published: July 2007

AbstractSsn6, a tetratricopeptide repeat (TPR) containing protein, associates with the Tup1 repressor to form a global transcriptional co‐repressor complex, which is conserved across species. The three N‐terminal TPR repeats of Ssn6, out of a total of 10, are involved in this particular interaction. Our previously reported 3D‐modeling and mutagenesis data suggested that the structural integrity of TPR1 and its correct positioning relatively to TPR2 are crucial for Tup1 binding. In this study, we first investigate the structural stability of the Tup1 binding domain of Ssn6, in pure form, through a combination of CD spectroscopy and limited proteolysis mapping. The obtained data were next combined with molecular dynamics simulations and disorder/order predictions. This combined study revealed that, although competent to fold, in the absence of Tup1, TPR1 is partially unfolded with its helix B being highly dynamic exposing an apolar surface to the solvent. Subsequent CD spectroscopy on this domain complexed with a Tup1 fragment comprising its Ssn6 binding region provided strong evidence for a conformational change consisting of acquisition of α‐helical structure with simultaneous stabilization of a coiled‐coil configuration upon complex formation. We propose that this conformational change occurs largely in the TPR1 of Ssn6 and is in accord with the concept of folding coupled to binding, proposed for other TPR domains. A possible implication of the structural flexibility of Ssn6 TPR1 in Tup1 recognition is discussed and a novel mode of interaction is proposed for this particular TPR‐mediated complex. Proteins 2008. © 2007 Wiley‐Liss, Inc.