bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the Mechanism of KLF15 on the Biological Activity and
Autophagy of Gastric Cancer Cells based on PI3K/Akt/Mtor Signaling
Pathway
Authors: Wang Xu , Liu Jiang , Xi Shihang , Pan Xuan , Fang Xiaosan 
Published: April 2024

Objective:
To explore the mechanism of KLF15 on the biological activity and autophagy
of gastric cancer cells based on the PI3K/Akt/mTOR signaling pathway.

Material and Methods:
The gastric cancer AGS cells were divided into the Con group, pcDNANC
group, pcDNA-KLF15 group, LY294002 group and IGF-1 group. RT-PCR was used to detect
the expression of KLF15 in human gastric mucosal cells and gastric cancer cells; MTT
method to detect cell proliferation; Transwell method to detect cell invasion; flow cytometry to
detect cell apoptosis; Western blotting to detect PI3K, Akt, mTOR in cells, LC3, Beclin1, p62
protein expression.P<0.05 was used to indicate statistical significance.

Results:
Compared with the human gastric mucosal cell line GES-1 cells, the expression of
KLF15 in human gastric cancer cell lines MKN-28, MFC, SCG-7901 and AGS cells was significantly
decreased, And the expression of KLF15 in AGS cells, was the lowest (P=0.006). Compared
with the Con group, The expression of KLF15 in the cells of the PCDNA-KLF15 group
was significantly increased (P=0.018); There was no significant difference in the expression of
KLF15 between the Con group and the PCDNA-NC group (P=0.225). Compared with the Con
group, the proliferation and invasion abilities of the cells in the pcDNA-KLF15 group were significantly
reduced, And the apoptosis ability was significantly increased (P=0.019). The ratio of
LC3II/LC31 and the expression of Beclin1 Protein in the control group were significantly higher
than those in the Con group (P=0.017).

Conclusion:
Overexpression of KLF15 can inhibit the proliferation and invasion of Gastric cancer
cells and promote cell apoptosis and autophagy, and its mechanism may be related to the regulation
of the PI3K/Akt/mTOR signaling pathway.
Alleviating Neurodegenerative Diseases Associated with Mitochondrial
Defects by Therapeutic Biomolecules
Authors: Roy Tanmoy , Padhi Swarupanjali , Mazumder Rupa , Majee Chandana , Das Saumya , Monika  , Mishra Rashmi , Kapoor Bhupinder 
Published: April 2024

Abstract:
Neurodegenerative diseases are emerging as a global health concern in the current scenario,
and their association with mitochondrial defects has been a potential area of research. Mitochondria,
one of the essential organelles of the cell, serve as the cell's powerhouse, producing
energy and ensuring cellular health. Neurodegenerative diseases such as Alzheimer's, Parkinson's,
Huntington's, amyotrophic lateral sclerosis, and Pelizaeus-Merzbacher disease have been found to
be primarily triggered by mitochondrial malfunction. One of the key byproducts of mitochondrial
respiration, reactive oxygen species, also contributes significantly to mitochondrial DNA mutations
that eventually cause mitochondrial breakdown.

:
This review paper comprehensively examines the potential of therapeutic biomolecules, specifically
mitochondria-specific antioxidants, in mitigating the impact of mitochondrial defects on
neurodegenerative diseases. It provides a detailed analysis of the mechanisms involved in mitochondrial
dysfunction, the potential therapeutic targets of these biomolecules, and their structureactivity
relationship information are also discussed in this review.

:
Various research articles and publications were used extensively in compiling the data, and the
structures of biomolecules were prepared using software such as ChemDraw and ChemSketch.

:
Crucial elements triggering mitochondrial abnormalities were identified and a tabular compilation
of bioactive antioxidant compounds along with their therapeutic targets, was presented.

:
Mitochondria-specific antioxidant therapy is an innovative and promising strategy for the management
of neurodegenerative diseases associated with mitochondrial defects. This review provides
a thorough summary of the current state of research and promising avenues of research and
development in this field, emphasizing the importance of further investigations and clinical trials
to elucidate their therapeutic benefits.
Quinolone Derivatives as Anticancer Agents: Importance in Medicinal Chemistry
Authors: Azzman Nursyuhada , Anwar Sirajudheen , Syazani Mohamed Wan Ahmad , Ahemad Nafees 
Published: April 2024

Abstract::
Quinolone is a heterocyclic compound containing carbonyl at the C-2 or C-4 positions with nitrogen at the C-1 position. The scaffold was first identified for its antibacterial properties, and the derivatives were known to possess many pharmacological activities, including anticancer. In this review, the quinolin-2(H)-one and quinolin-4(H)-one derivatives were identified to inhibit several various proteins and enzymes involved in cancer cell growth, such as topoisomerase, mi-crotubules, protein kinases, phosphoinositide 3-kinases (PI3K) and histone deacetylase (HDAC). Hybrids of quinolone with curcumin or chalcone, 2-phenylpyrroloquinolin-4-one and 4-quinolone derivatives have demonstrated strong potency against cancer cell lines. Additionally, quinolones have been explored as inhibitors of protein kinases, including EGFR and VEGFR. Therefore, this review aims to consolidate the medicinal chemistry of quinolone derivatives in the pipeline and discuss their similarities in terms of their pharmacokinetic profiles and potential target sites to provide an understanding of the structural requirements of anticancer quinolones.
A Case Report of an Endobronchial Tuberculosis-Challenges in Diagnosis and the Role of High-resolution CT Scans and Bronchoscopic Biopsy
Authors: Hanh Doan Le Minh 
Published: April 2024

Introduction:
Endobronchial tuberculosis is a challenging disease to diagnose, characterized
by infection of the tracheobronchial tree caused by Mycobacterium Tuberculosis. The clinical
presentation of endobronchial tuberculosis is nonspecific and variable, making it difficult to
identify.

Case Report:
This report explores the challenges faced during the diagnosis of endobronchial tuberculosis
by a 63-year-old female patient presented with a chronic cough lasting over two
months. Her chest X-ray revealed an inhomogeneous opacity in the left middle zone, accompanied
by an air-bronchogram. Conventional sputum samples and other tests returned negative results.
A high-resolution chest CT scan was almost complete consolidation in the lingular subsegment.
A comprehensive re-evaluation was recommended in this case due to slow re-solving or
non-resolving pneumonia. The histopathological examination of the biopsy sample revealed granulomatous
inflammation with necrosis and lymphocytic infiltration, strongly indicating bronchial
tuberculosis. The Hain test and MGIT culture confirmed the presence of Mycobacterium tuberculosis.

Conclusion:
Diagnosing endobronchial tuberculosis can be challenging due to its nonspecific and
variable clinical presentation. High-resolution CT scans provide valuable insights, but the absence
of typical findings can complicate the diagnosis. Bronchoscopic biopsy proved to be the most reliable
method for diagnosing endobronchial tuberculosis in this case. Early and accurate diagnosis
is crucial for initiating appropriate treatment and preventing complications.
Design and Implementation of Long Range Wide Area Networks for
Future Industrial IoT Applications
Authors: Mariappan Ramasamy 
Published: April 2024

Background:
The evolution of Long Range Wide Area Networks (LoRaWAN) is a potential
candidate for next generation networks for managing the massive number of devices in the
Industrial Internet of Things (IIoT). LoRaWAN is more suitable for transmitting smaller intermittent
data but using smaller bandwidth over a long distance.

Objective:
This research paper proposes to design a Low Power Wide Area Network (LPWAN) to
provide long-range data transfer for Industrial IoT applications, especially for industrial sensor data.

Methods:
This research work deploys the experimental setup of LoRaWAN devices using LoRa
gateways and Internet of Things network server to evaluate its performance for IIOT applications.

Results:
The deployment of this LoRaWAN has demonstrated its long range, low power, stability
and low deployment cost through extensive performance evaluation carried out. LoRaWAN has
been analyzed for its coverage and throughput performance.

Conclusion:
Through performance analysis, potential enhancements have been identified to overcome
its shortcomings. This paper concludes the feasibility of deploying LoRaWAN technology for
the future generation IIOT applications.
Prediction of LncRNA-protein Interactions Using Auto-Encoder,
SE-ResNet Models and Transfer Learning
Authors: Huiwen Jiang , Kai Song 
Published: April 2024

Background:
Long non-coding RNA (lncRNA) plays a crucial role in various biolog-ical processes, and mutations or imbalances of lncRNAs can lead to several diseases, including cancer, Prader-Willi syndrome, autism, Alzheimer's disease, cartilage-hair hypoplasia, and hear-ing loss. Understanding lncRNA-protein interactions (LPIs) is vital for elucidating basic cellular processes, human diseases, viral replication, transcription, and plant pathogen resistance. Despite the development of several LPI calculation methods, predicting LPI remains challenging, with the selection of variables and deep learning structure being the focus of LPI research.

Methods:
We propose a deep learning framework called AR-LPI, which extracts sequence and secondary structure features of proteins and lncRNAs. The framework utilizes an auto-encoder for feature extraction and employs SE-ResNet for prediction. Additionally, we apply transfer learning to the deep neural network SE-ResNet for predicting small-sample datasets.

Results:
Through comprehensive experimental comparison, we demonstrate that the AR-LPI ar-chitecture performs better in LPI prediction. Specifically, the accuracy of AR-LPI increases by 2.86% to 94.52%, while the F-value of AR-LPI increases by 2.71% to 94.73%.

Conclusion:
Our experimental results show that the overall performance of AR-LPI is better than that of other LPI prediction tools.
Environmentally Compatible Poly (Vinyl Alcohol)/Banana Peel Nano Crystals/Bentonite Clay-based Composites Films: Influence of Nano Filler on Biodegradation Behavior
Authors: Kohli Deepak , Panwar D.S. , Tudu Balraj , Mehta Jigesh , Shah Vishal , Patel Jigna , Patel Bital , Oza Ankit D. , Gupta Ravi , Singh Laxman 
Published: April 2024

Objective:
The present work shows the effect of Bentonite Clay (BC) on the biodegradation
behavior of Poly Vinyl Alcohol (PVA)/Banana Peel Nano Crystals (BPNC) composite films.

Method:
Biodegradation studies were conducted using soil burial and bacterial degradation method.
The prepared composite films were characterized by scanning electron microscopy.

Results:
Biodegradation studies reported that the composite films were more degradable in bacterial
environment as compared to natural soil burial. The addition of Bentonite Clay (BC) had negative
effect on degradation rate of composite films.

Conclusion:
PVA/BPNC/BC composite film showed less weight loss (%) as compared to
PVA/BPNC composite films because BC had stabilizing effect against the microbial attack which
prevents biodegradation.
An Engineering Alternative to Lockdown During COVID-19 and Other Airborne Infectious Disease Pandemics: Feasibility Study
Authors: Fujii Yusaku 
Published: April 2024

Background
Now and in the future, airborne diseases such as COVID-19 could become uncontrollable and lead the world into lockdowns. Finding alternatives to lockdowns, which limit individual freedoms and cause enormous economic losses, is critical.

Objective
The purpose of this study was to assess the feasibility of achieving a society or a nation that does not require lockdown during a pandemic due to airborne infectious diseases through the mass production and distribution of high-performance, low-cost, and comfortable powered air purifying respirators (PAPRs).

Methods
The feasibility of a social system using PAPR as an alternative to lockdown was examined from the following perspectives: first, what PAPRs can do as an alternative to lockdown; second, how to operate a social system utilizing PAPR; third, directions of improvement of PAPR as an alternative to lockdown; and finally, balancing between efficiency of infection control and personal freedom through the use of Internet of Things (IoT).

Results
PAPR was shown to be a possible alternative to lockdown through the reduction of airborne and droplet transmissions and through a temporary reduction of infection probability per contact. A social system in which individual constraints imposed by lockdown are replaced by PAPRs was proposed, and an example of its operation is presented in this paper. For example, the government determines the type and intensity of the lockdown and activates it. At that time, the government will also indicate how PAPR can be substituted for the different activity and movement restrictions imposed during a lockdown, for example, a curfew order may be replaced with the permission to go outside if wearing a PAPR. The following 7 points were raised as directions for improvement of PAPR as an alternative method to lockdown: flow optimization, precise differential pressure control, design improvement, maintenance method, variation development such as booth type, information terminal function, and performance evaluation method. In order to achieve the effectiveness and efficiency in controlling the spread of infection and the individual freedom at a high level in a social system that uses PAPRs as an alternative to lockdown, it was considered effective to develop a PAPR wearing rate network management system utilizing IoT.

Conclusions
This study shows that using PAPR with infection control ability and with less economic and social damage as an alternative to nationwide lockdown is possible during a pandemic due to airborne infectious diseases. Further, the efficiency of the government’s infection control and each citizen’s freedom can be balanced by using the PAPR wearing rate network management system utilizing an IoT system.
Associations of Dietary Cholesterol Consumption With Incident Diabetes and Cardiovascular Disease: The Role of Genetic Variability in Cholesterol Absorption and Disease Predisposition
Authors: Shi Shuxiao , Dong Ying , Wang Sujing , Du Xihao , Feng Nannan , Xu Lan , Zhong Victor W. 
Published: April 2024

OBJECTIVE
Whether genetic susceptibility to disease and dietary cholesterol (DC) absorption contribute to inconsistent associations of DC consumption with diabetes and cardiovascular disease (CVD) remains unclear.

RESEARCH DESIGN AND METHODS
DC consumption was assessed by repeated 24-h dietary recalls in the UK Biobank. A polygenetic risk score (PRS) for DC absorption was constructed using genetic variants in the Niemann-Pick C1-Like 1 and ATP Binding Cassettes G5 and G8 genes. PRSs for diabetes, coronary artery disease, and stroke were also created. The associations of DC consumption with incident diabetes (n = 96,826) and CVD (n = 94,536) in the overall sample and by PRS subgroups were evaluated using adjusted Cox models.

RESULTS
Each additional 300 mg/day of DC consumption was associated with incident diabetes (hazard ratio [HR], 1.17 [95% CI, 1.07–1.27]) and CVD (HR, 1.09 [95% CI, 1.03–1.17]), but further adjusting for BMI nullified these associations (HR for diabetes, 0.99 [95% CI, 0.90–1.09]; HR for CVD, 1.04 [95% CI, 0.98–1.12]). Genetic susceptibility to the diseases did not modify these associations (P for interaction ≥0.06). The DC-CVD association appeared to be stronger in people with greater genetic susceptibility to cholesterol absorption assessed by the non-high-density lipoprotein cholesterol-related PRS (P for interaction = 0.04), but the stratum-level association estimates were not statistically significant.

CONCLUSIONS
DC consumption was not associated with incident diabetes and CVD, after adjusting for BMI, in the overall sample and in subgroups stratified by genetic predisposition to cholesterol absorption and the diseases. Nevertheless, whether genetic predisposition to cholesterol absorption modifies the DC-CVD association requires further investigation.
CONNECTING THE DOTS THROUGH INTERDISCIPLINARY LITERARY STUDIES: PSYCHOANALYSIS, COSMOPOLITANS, MENTAL HEALTH, POVERTY, AND URBANISM. BOOK REVIEW: ANKHI MUKHERJEE’S UNSEEN CITY: THE PSYCHIC LIVES OF THE URBAN POOR, 2021, OXFORD UNIVERSITY PRESS. 263 PAGES.
Authors: Tong Chong Seng , Abd Rahman Ahmad Zufrie , Abu Bakar Roslina 
Published: April 2024

This paper reviews the conceptual and theoretical framework propounded by Ankhi Mukherjee. Her framework is developed through rigorous analyses of literary texts from diverse genres. It is philosophically underpinned in psychoanalysis and postcolonial studies. The interdisciplinary framework is eclectic in nature and it can be used in trauma studies, ageing population, mental health, health communication, and urban studies. This paper delineates the development of the framework and its application.

Keywords: Psychoanalysis, postcolonialism, interdisciplinary analysis, population studies, urbanism.

Cite as: Chong, S. T., Abd Rahman, A. Z., & Abu Bakar, R. (2024). Connecting the dots through interdisciplinary literary studies: Psychoanalysis, cosmopolitans, mental health, poverty, and urbanism. (Book review). Journal of Nusantara Studies, 9(1), 139-142. http://dx.doi.org/10.24200/jonus.vol9iss1pp139-142
THE RISE OF VIRTUAL BANKS: FACTORS INFLUENCING ITS ADOPTION USING TRUTAUT FRAMEWORK
Authors: Mohamad Yusof Nurul Afidah , Anthonysamy Lilian 
Published: April 2024

Background and Purpose: In 2022, the Malaysian central bank granted five licenses to run virtual banks. Despite the high online banking usage in Malaysia, virtual banking is still considered a new experience to potential users and may present challenges as individuals may exhibit resistance and hesitance to adopt. Hence, understanding the factors influencing the intention to adopt virtual banking is crucial for its successful implementation and widespread acceptance. The objective of this study is twofold: 1) to examine the current technology readiness of customers, and 2) to examine the factors influencing customers’ intention to adopt virtual banking in Malaysia.

Methodology: This study adopts a quantitative method where questionnaires were distributed to bank customers as the target population. Data gathered from 157 respondents was analysed using variance-based partial least squares structural equation modelling (PLS-SEM) method.

Findings: The findings of this study revealed that optimism and innovativeness are significant motivators to shape an individual’s positive perception of the use of technology. Meanwhile, bank reputation, performance expectancy, and facilitating conditions have a significant influence on the intention to adopt virtual banking.

Contributions: In light of the inaugural award of digital banking licenses by Bank Negara Malaysia, this study offers valuable insights to the virtual banks to effectively promote the adoption of virtual banking in Malaysia. By combining Technology Readiness (TR) and Unified Theory of Acceptance and Use of Technology (UTAUT) into one research framework, this study employs an integrated model (TRUTAUT) which will provide a more in-depth understanding of the factors influencing customers to adopt the new virtual banking phenomenon in Malaysia. This integrated model posits that both personality dimensions and system-specific dimensions, as represented by TR and UTAUT respectively, have a significant bearing on the customers’ propensity to adopt new technology. In addition, this study also introduces bank reputation construct, which is believed to be important in influencing customer intention to adopt virtual banking.

Keywords: Virtual bank, digital transformation, Technology Readiness (TR), Unified Theory of Acceptance and Use of Technology (UTAUT).

Cite as: Mohamad Yusof, N. A., & Anthonysamy, L. (2024). The rise of virtual banks: Factors influencing its adoption using TRUTAUT framework. Journal of Nusantara Studies, 9(1), 148-173. http://dx.doi.org/10.24200/jonus.vol9iss1pp148-173
FACTORS INFLUENCING ONLINE SHOPPING BEHAVIOUR OF YOUTH CUSTOMERS IN MALAYSIA AFTER COVID-19 PANDEMIC
Authors: Binti Rahlin Nor Azma , Jas Ozzy , Mohamad Fauzi Siti Nadhirah , @ Siti Aisyah Bahkia Ayu Suriawaty 
Published: April 2024

Background and Purpose: The Movement Control Order (MCO) requires a higher demand for online services. In light of recent events in the business environment, it is becoming challenging to ignore online channels, including online shopping platforms. The current study investigates the impact of customer satisfaction, convenience, social media influence, and website on online shopping behaviour.

Methodology: Two hundred respondents were selected based on the convenience sample. Online questionnaires were distributed to young Kota Kinabalu, Sabah, Malaysia customers. This case study was conducted after the Covid-19 pandemic in Kota Kinabalu, Sabah. Harman's Single Factor Test, Validity test, and Partial Least Square Structural Equation Model were used to validate the model of this study and the relationship between constructs.

Findings: The results reveal that customer satisfaction, convenience, and social media influence are significantly related to the online shopping behaviour of youth in Malaysia after Covid-19 pandemic. Furthermore, the relationship between customer satisfaction and online shopping behaviour is higher than that between other factors in this study model.
Contributions: In theory, this study contributes to understanding Malaysian youth customers' online shopping behaviour. Businesses must take full advantage of e-commerce platforms to ensure customer satisfaction and build customer trust through online shopping services.

Keywords: Convenience, customer satisfaction, online shopping behaviour, youth customers, social media influence.

Cite as: Rahlin, N. A., Jas, O., Fauzi, S. N. M., & Bahkia, A. S. S. A. (2024). Factors influencing online shopping behaviour of youth customers in Malaysia after Covid-19 pandemic. Journal of Nusantara Studies, 9(1), 193-223. http://dx.doi.org/10.24200/jonus.vol9iss1pp193-223