bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of fractals in determining the malignancy degree of lung nodules
Authors: Amador-Legon Noel Victor , Perez-Diaz Marlen 
Published: March 2024

IntroductionA Computer-Assisted Detection (CAD) System for classification into malignant-benign classes using CT images is proposed.MethodsTwo methods that use the fractal dimension (FD) as a measure of the lung nodule contour irregularities (Box counting and Power spectrum) were implemented. The LIDC-IDRI database was used for this study. Of these, 100 slices belonging to 100 patients were analyzed with both methods.ResultsThe performance between both methods was similar with an accuracy higher than 90%. Little overlap was obtained between FD ranges for the different malignancy grades with both methods, being slightly better in Power spectrum. Box counting had one more false positive than Power spectrum.DiscussionBoth methods are able to establish a boundary between the high and low malignancy degree. To further validate these results and enhance the performance of the CAD system, additional studies will be necessary.
Associations between the burdens of comorbid sleep problems, central sensitization, and headache-related disability in patients with migraine
Authors: Suzuki Keisuke , Suzuki Shiho , Haruyama Yasuo , Funakoshi Kei , Fujita Hiroaki , Sakuramoto Hirotaka , Hamaguchi Mai , Kobashi Gen , Hirata Koichi 
Published: March 2024

ObjectiveSleep disturbances are common in migraine patients and affect quality of life. Central sensitization (CS) is likely to play a role in the increased severity and chronicity of migraine. We hypothesized that the number of comorbid sleep problems would affect headache-related disability through the effects of central sensitization (CS).MethodsWe performed a cross-sectional study including 215 consecutive patients with migraine. Insomnia was defined as a Pittsburgh Sleep Quality Index (PSQI) global score greater than 5. Probable REM sleep behavior disorder (pRBD) was defined as an RBD screening score of 5 or greater. Excessive daytime sleepiness (EDS) was defined as an Epworth Sleepiness Scale score of 10 or higher. Suspected sleep apnea (SA) was defined as patients with snoring or sleep apnea witnessed 3 or more nights a week. CS was assessed by the Central Sensitization Inventory (CSI).ResultsRestless legs syndrome, insomnia, EDS, SA and pRBD were observed in 25.6%, 71.6%, 34.4%, 10.2%, and 21.4%, respectively, of the patients. At least one sleep problem was present in 87.0% of the patients. According to the results of the multinomial logistic regression analysis with no sleep problems as a reference, after we corrected for adjustment factors, the Migraine Disability Assessment (MIDAS) score significantly increased when three or more comorbid sleep problems were present. According to our mediation analysis, an increased number of sleep problems had a direct effect on the MIDAS score after we adjusted for other variables, and the CSI score was indirectly involved in this association.ConclusionThe present study showed an association between migraine-related disability and the burden of multiple sleep problems, which was partially mediated by CS.
Estimating preferences and willingness to pay for pharmacogenetic testing in populations who are medically underserved: a discrete choice experiment
Authors: Gawronski Brian E. , Salloum Ramzi G. , Duarte Julio D. 
Published: March 2024

Background: The implementation of pharmacogenetic (PGx) testing may contribute to health disparities if access to testing is inequitable, as medically underserved patients are prescribed higher rates of drugs with PGx guidelines and often experience the benefits of emerging health technologies last. Limited research has evaluated potential implementation of PGx testing in populations who are medically underserved and none have evaluated their preferences regarding PGx test characteristics and cost. Our study endeavored to assess the willingness to pay for PGx testing and key PGx test preferences in a nationwide cohort of medically underserved respondents.Methods: A survey was developed to assess willingness to pay and preferences for PGx testing through a discrete choice experiment (DCE). Five attributes of PGx tests were included in the DCE: doctor recommendation, wait time, number of actionable results, benefit of the test (avoid a side effect or address a health problem), and out-of-pocket cost. A convenience sample of U.S. adults with an average yearly household income of $42,000 or less was collected utilizing an online survey fielded by Qualtrics Research Services (Provo, UT). For the DCE analysis, conditional logit and mixed-logit regression models were utilized to determine relative utility of attributes and levels, conditional relative importance for each attribute, and marginal willingness to pay.Results: Respondents completed the survey with an 83.1% response completion rate. Following quality control procedures, 1,060 respondents were included in the final nationwide cohort. Approximately, 82% of respondents were willing to pay less than $100 for PGx testing, and a strong price ceiling was identified at $200. Out-of-pocket cost was the attribute identified as having the greatest relative importance on choice, while wait time had the lowest importance. Greater utility was observed if the PGx test was doctor recommended, had a higher number of actionable results, and resolved major or minor health problems compared with avoiding side effects.Conclusion: This first-of-its-kind study provides important insights into the willingness to pay for PGx testing and PGx test preferences of a large medically underserved population. Applying these findings can potentially lead to improvements in the successful implementation of PGx testing in this population.
Sex-specific colonic mitochondrial dysfunction in the indomethacin-induced rat model of inflammatory bowel disease
Authors: Hoang Ngoc , Brooks Karen , Edwards Kristin 
Published: March 2024

Introduction: Inflammatory bowel disease (IBD) is characterized by chronic inflammation of the gastrointestinal tract and encompasses Crohn’s Disease and Ulcerative Colitis. Women appear to have more severe and recurring symptoms of IBD compared to men, most likely due to hormonal fluctuations. Studies have shown that mitochondrial dysfunction plays a role in the development of inflammation and there is evidence of colon mitochondrial alterations in IBD models and patients. In this study we have identified the presence of sex-specific colon mitochondrial dysfunction in a rat model of IBD.Methods: Eight-week-old male and female rats were treated with indomethacin to induce IBD and mitoTEMPO was administered daily either after or before induction of IBD and until euthanasia. Colons were collected for histology and mitochondrial experiments. Intact mitochondrial respiration, reactive oxygen species (mtROS), the activities of the individual electron transport complexes and the activities of the antioxidant enzymes were measured to assess mitochondrial function.Results: IBD male rats showed a decrease in citrate synthase activity, cardiolipin levels, catalase activity and an increase in mtROS production. IBD females show a decrease in intact colon mitochondrial respiration, colon mitochondria respiratory control ratio (RCR), complex I activity, complex IV activity, and an increase in mtROS. Interestingly, control females showed a significantly higher rate of complex I and II-driven intact mitochondrial respiration, MCFA oxidation, complex II activity, complex III activity, and complex IV activity compared to control males. The use of a mitochondrial-targeted therapy, mitoTEMPO, improved the disease and colon mitochondrial function in female IBD rats. However, in the males there was no observed improvement, likely due to the decrease in catalase activity.Conclusion: Our study provides a better understanding of the role mitochondria in the development of IBD and highlights sex differences in colon mitochondrial function. It also opens an avenue for the development of strategies to re-establish normal mitochondrial function that could provide more options for preventive and therapeutic interventions for IBD.
Exercise, weight maintenance, and nonalcoholic fatty liver disease risk: a Chinese cohort study
Authors: Yang Chao , Yan Peijing , Deng Jiaqi , Li Yujuan , Jiang Xia , Zhang Ben 
Published: March 2024

Background: Exercise has been reported to be associated with a reduced risk of nonalcoholic fatty liver disease (NAFLD), but there is no consensus on the role of weight changes in this association. This study aims to investigate whether the impact of exercise on NAFLD is mainly dependent on weight changes or is inherent to exercise itself.Methods: The study recruited 1671 Chinese NAFLD-free adults in 2019, and collected their exercise habits as well as 3 years of medical examination data including anthropometric measurements, blood biochemistry parameters, and liver ultrasound results. Univariate and multivariate logistic regression models were employed to examine the impact of exercise habits on NAFLD risk, with mediation analysis utilized to estimate the magnitude of the role of weight maintenance in the association between exercise and NAFLD.Results: After adjusting for confounders, moderate to high-intensity exercisers were 1.56 times (95% CIs = 1.09–2.22) more likely to successfully control their body weight, and therefore the weight-controlled group had a lower NAFLD risk of 34.9% (95% CIs = 21.8%–56.0%) compared to the weight-gain group. Mediation analysis reveals that exercise can significantly reduce the risk of NAFLD both through weight maintenance (37.1%) and independent of weight maintenance (62.9%).Conclusion: It might be more crucial to emphasize the adoption of regular moderate to high-intensity exercise for preventing NAFLD in the general population, rather than solely focusing on weight maintenance.
Mindfulness, self-efficacy, and self-regulation as predictors of psychological well-being in EFL learners
Authors: Fan Lijuan , Cui Feng 
Published: March 2024

IntroductionMindfulness, self-efficacy, and self-regulation play vital roles in shaping the psychological well-being of English as a Foreign Language (EFL) learners. This study investigates the interconnections among these constructs and their implications for the psychological well-being of 527 Chinese EFL learners.MethodsA cross-sectional study was conducted among Chinese EFL learners enrolled in a university in China. Participants were recruited through a non-probability convenience sampling method from English language courses. They completed validated self-report questionnaires assessing mindfulness, self-efficacy, self-regulation, and psychological well-being. Structural Equation Modeling (SEM) and mediation analysis were employed to explore the relationships among these constructs.ResultsThe study found that mindfulness and self-efficacy independently and directly predicted psychological well-being among Chinese EFL learners. Additionally, self-regulation emerged as a significant mediator in the relationship between mindfulness and psychological well-being, suggesting that mindfulness enhances well-being indirectly through improved self-regulation skills.DiscussionThese findings underscore the critical roles of mindfulness practices, self-efficacy beliefs, and self-regulation skills in promoting psychological well-being among EFL learners. The implications of this study extend to mindfulness-based interventions and programs designed. However, the study’s cross-sectional design limits causal inference, and the use of self-report measures may introduce biases. Moreover, the sample’s limited diversity and homogeneous demographic profile, attributed to the convenience sampling from a single university, may constrain the generalizability of the findings. Future research could adopt longitudinal designs and diverse participant samples to further elucidate these relationships and enhance the robustness of the findings.
Competitive organizational climate and artificial intelligence (AI) acceptance: the moderating role of leaders’ power construal
Authors: Fousiani Kyriaki , Michelakis Georgios , Minnigh Pieter A. , De Jonge Kiki M. M. 
Published: March 2024

IntroductionThe incorporation of Artificial Intelligence (AI) in organizations is pivotal to deal with work-related tasks and challenges effectively, yet little is known about the organizational factors that influence AI acceptance (i.e., employee favorable AI attitudes and AI use). To address this limitation in the literature and provide insight into the organizational antecedents influencing AI acceptance, this research investigated the relationship between competitive organizational climate and AI acceptance among employees. Moreover, given the critical role of a leader in employee attitude and behavior, we examined the moderating role of leaders’ power construal as responsibility or as opportunity in this relationship.MethodsStudy 1 was a three-wave field study among employees (N = 237, Mage = 38.28) working in various organizations in the UK. The study measured employees’ perception of a competitive organizational climate at Time 1, leaders’ power construal (as perceived by employees) at Time 2, and employee attitudes towards AI and their actual use of AI in the workplace at Times 2 and 3. Study 2 was a 2 (climate: highly competitive vs. low competitive) by 2 (power construal: responsibility vs. opportunity) experiment among employee participants (N = 150, Mage = 37.50).ResultsStudy 1 demonstrated a positive relationship between competitive climate and employee AI use over time. Furthermore, both studies revealed an interaction between competitive climate and leader’s power construal in the prediction of employee AI acceptance: In Study 1, competitive climate was negatively related to AI acceptance over time when leaders construed power as opportunity. In Study 2 competitive climate was positively related to AI acceptance when leaders construed power as responsibility rather than as opportunity.DiscussionThese results underscore the organizational factors that are required in order for employees to shape favorable attitudes towards AI and actually use AI at work. Importantly, this research expands the limited body of literature on AI integration in organizations.
Participatory intention and behavior towards riparian peri-urban forests management; an extended theory of planned behavior application
Authors: Maleknia Rahim , ChamCham Jyran 
Published: March 2024

IntroductionPeri-urban forests play crucial role in quality of life and environment for citizens. To effectively utilize the services provided by these forests, it is essential to establish an integrated forest management system that aims to achieve a balance of all ecosystem services. This can be accomplished through a participatory approach that involves key citizen stakeholders. Mountaineers shape a specific group which have showed high pro-environmental behaviors to protect natural resources. This research aimed to examine the influencing factors on mountaineers’ intention to participate and their actual behavior in the management of riparian peri-urban forests in this field using extended theory of planned behavior.MethodsEnvironmental values and perceived barriers were added to original model as additional components to enhance its explanatory power. A sample size of 416 individuals was surveyed using a questionnaire. Data was analyzed using Smart-PLS.ResultsThe findings of the analysis revealed that the developed model accounted for 75.2% of the variance in mountaineers’ intention and 67.8% of behavior. The results demonstrated that three main components of model including attitudes, subjective norms and perceived behavioral control significantly influenced individuals’ intentions to participate in peri-urban forests management. Furthermore, intentions were cleared to have a positive influence on actual behavior in this context. Additionally, environmental values were found to be positively correlated with individuals’ intentions but not statistically significant behavior toward participate in urban forest management. Perceived barriers were found to have a negative impact on individuals’ intentions toward participate in urban forest management. The perceived barriers and behavior had not statistically significant relationship.ConclusionThe results of study provide valuable insights for the development of effective management strategies to promote mountaineers’ participation in riparian PUFs management. The study emphasizes the importance of environmental education and awareness campaigns targeted at mountaineers.
Association between hs-CRP and depressive symptoms: a cross-sectional study
Authors: Ji Yewei , Wang Jinmin , Chen Huaqin , Li Jiawen , Chen Mingyang 
Published: March 2024

Background and aimHigh-sensitivity C-reactive protein (hs-CRP) is a sensitive measure of low-grade inflammation and appears superior to conventional blood tests in assessing cardiovascular disease. The purpose of this investigation was to explore the link between high-sensitivity CRP and depressive symptoms among adults.Methods and resultsMultiple logistic regression and smoothed curve fitting were used to investigate the association between hs-CRP and depressive symptoms based on data from the, 2017-2020 National Health and Nutrition Examination Survey (NHANES). Subgroup analyses and interaction tests were used to assess the stability of this relationship across populations. The study comprised 6,293 non-clinical participants, which included 549 individuals with depressive symptoms. The prevalence of depressive symptoms was found to increase with increasing levels of hs-CRP. This trend persisted even after quartetting hs-CRP levels. In the fully adjusted model, each unit increase in hs-CRP was associated with a 10% increase in the odds of depressive symptoms (OR=1.10,95%CI:1.01-1.21). Participants in the highest quartile of hs-CRP had a 39% higher prevalence of depressive symptoms compared to those in the lowest quartile (OR=1.39,95%CI:1.01-1.92). Additionally, this positive correlation was more pronounced in men.ConclusionsIn adult Americans, there exists a positive association between elevated hs-CRP levels and depressive symptoms, with a more prominent manifestation of this association observed in males.
Model of structural equations on the perception of aspects of school life and substance consumption as predictors of problem behavior in adolescents
Authors: Villanueva-Blasco Víctor J. , González Amado Bárbara , Colomo Magaña Ernesto , Puig-Perez Sara 
Published: March 2024

IntroductionProblematic behavior and drug use are behaviors of social concern, especially in adolescence. There are school factors that can contribute to their development or prevent them. The objective was to establish explanatory models of the relationship between various school variables with the consumption of alcohol, tobacco and cannabis; determining its direct and/or indirect relationship with problematic behaviors.Materials and methodsThe study was cross-sectional with a sample of 346 students (Main Age=14.81; 54% women) from secondary education. Structural Equation Model (SEM) were carried to analyze the relationship between the dimensions of the Scale of perception of aspects of school life and alcohol, tobacco and cannabis consume with the presence of Problematic Behavior.ResultsProblem behavior was predicted by alcohol, tobacco and cannabis consume, and binge drinking. Different aspects of school life differentially predicted problem behavior and drug use. Sense of challenge was observed as having a reciprocal predictive relationship with problem behavior. Perception of oneself at school predicts both alcohol and tobacco use; while the value given to school predicts binge drinking.DiscussionThese findings suggests that, when addressing problem behavior and drug use that affect minors in school and have repercussions on class dynamics and academic outcomes, we should not focus exclusively on these problem areas, but rather take a more integrated approach that includes modifying different school-related aspects that act as risk factors for these types of problems.
Utilizing symbiotic relationships and assisted migration in restoration to cope with multiple stressors, and the legacy of invasive species
Authors: Markovchick Lisa M. , Belgara-Andrew Abril , Richard Duncan , Deringer Tessa , Grady Kevin C. , Hultine Kevin R. , Allan Gerard J. , Whitham Thomas G. , Querejeta José Ignacio , Gehring Catherine A. 
Published: March 2024

IntroductionClimate change has increased the need for forest restoration, but low planting success and limited availability of planting materials hamper these efforts. Invasive plants and their soil legacies can further reduce restoration success. Thus, strategies that optimize restoration are crucial. Assisted migration and inoculation with native microbial symbiont communities have great potential to increase restoration success. However, assisted migrants can still show reduced survival compared to local provenances depending on transfer distance. Inoculation with mycorrhizal fungi, effective if well-matched to plants and site conditions, can have neutral to negative results with poor pairings. Few studies have examined the interaction between these two strategies in realistic field environments where native plants experience the combined effects of soil legacies left by invasive plants and the drought conditions that result from a warming, drying climate.MethodsWe planted two ecotypes (local climate and warmer climate) of Populus fremontii (Fremont cottonwoods), in soils with and without legacies of invasion by Tamarix spp. (tamarisk), and with and without addition of native mycorrhizal fungi and other soil biota from the warmer climate.ResultsFour main results emerged. 1) First year survival in soil legacies left behind after tamarisk invasion and removal was less than one tenth of survival in soil without a tamarisk legacy. 2) Actively restoring soil communities after tamarisk removal tripled first year cottonwood survival for both ecotypes, but only improved survival of the warmer, assisted migrant ecotype trees in year two. 3) Actively restoring soil communities in areas without a tamarisk history reduced first year survival for both ecotypes, but improved survival of the warmer, assisted migrant ecotype trees in year two. 4) By the second year, inoculated assisted migrants survived at five times the rate of inoculated trees from the local ecotype.DiscussionResults emphasize the detrimental effects of soil legacies left after tamarisk invasion and removal, the efficacy of assisted migration and restoring soil communities alongside plants, and the need to thoughtfully optimize pairings between plants, fungi, and site conditions.