bluuebunny/crossref_metadata_2025_split huggingface dataset:
A non-zero Doppler amplitude is not enough: revisiting the putative radial velocity detection of sub-Venus exoplanet L 98-59b
Authors: Rajpaul Vinesh M , Barragán Oscar , Zicher Norbert 
Published: March 2024

ABSTRACT
L 98-59b is a transiting exoplanet with radius ${0.85^{+0.061}_{-0.047}}$R⊕ and orbital period ${2.2531136^{+1.2e-06}_{-1.5e-06}}$ d. In 2021, a Doppler detection of  L 98-59b was announced, with radial velocity (RV) semi-amplitude $K_{\rm b}=0.46^{+0.20}_{-0.17}$$\textrm {m}\, \textrm {s}^{-1}$ inferred from 164 High Accuracy Radial velocity Planet Searcher and 66 Échelle SPectrograph for Rocky Exoplanets and Stable Spectroscopic Observation RVs. This translated into a mass $M_{\rm b}=0.40^{+0.16}_{-0.15}$M⊕, or half the mass of Venus, making  L 98-59b then (by far) the lowest mass planet with a putative RV detection. To illuminate the difficulties in securely detecting &lt;1 $\textrm {m}\, \textrm {s}^{-1}$ signals, we argue here that the published RV detection of  L 98-59b is not supported by sufficient statistical evidence. We show, under the published modelling assumptions, that Bayesian model comparison (BMC) suggests an $\sim 50~{{\ \rm per\ cent}}$ false-detection probability. We also often infer ∼40 $\textrm {cm}\, \textrm {s}^{-1}$ semi-amplitudes for Keplerians with periods not corresponding to any known planet; importantly, though, BMC rejects all these ‘detections’. By implementing a more sophisticated stellar activity model and more realistic parameter priors, we infer a mass Mb = 0.47 ± 0.14M⊕ from semi-amplitude Kb = 0.56 ± 0.16 $\textrm {m}\, \textrm {s}^{-1}$, with BMC now indicating substantial yet still not decisive evidence for the detection. Definitive detection and characterization may require many additional RVs, alongside careful modelling and stringent statistical analysis. Our case study has implications for current extreme-precision RV campaigns and the longer term quest to discover the first Earth-twins.
ALMA reveals a compact and massive molecular outflow driven by the young AGN in a nearby ULIRG
Authors: Holden Luke R , Tadhunter Clive , Audibert Anelise , Oosterloo Tom , Ramos Almeida Cristina , Morganti Raffaella , Pereira-Santaella Miguel , Lamperti Isabella 
Published: March 2024

ABSTRACT
The ultraluminous infrared galaxy F13451+1232 is an excellent example of a galaxy merger in the early stages of active galactic nucleus (AGN) activity, a phase in which AGN-driven outflows are expected to be particularly important. However, previous observations have determined that the mass outflow rates of the warm ionized and neutral gas phases in F13451+1232 are relatively modest, and there has been no robust detection of molecular outflows. Using high-spatial resolution Atacama Large Millimeter/submillimeter Array CO(1–0) observations, we detect a kiloparsec-scale circumnuclear disc, as well as extended (r ∼ 440 pc), intermediate-velocity (300 &lt; |v| &lt; 400 km s−1) cold molecular gas emission that cannot be explained by rotational disc motions. If interpreted as AGN-driven outflows, the mass outflow rates associated with this intermediate-velocity gas are relatively modest ($\dot{M}_\mathrm{out}=22$–27 M⊙ yr−1); however, we also detect a compact (rout &lt; 120 pc), high-velocity (400 &lt; v &lt; 680 km s−1) cold molecular outflow near the primary nucleus of F13451+1232, which carries an order of magnitude more mass ($\dot{M}_\mathrm{out}$ ∼ 230 M⊙ yr−1) than (and several times the kinetic power of) the previously detected warmer phases. Moreover, the similar spatial scales of this compact outflow and the radio structure indicate that it is likely accelerated by the small-scale (r ∼ 130 pc) AGN jet in the primary nucleus of F13451+1232. Considering the compactness of the nuclear outflow and intermediate-velocity non-rotating gas that we detect, we argue that high-spatial resolution observations are necessary to properly quantify the properties of AGN-driven outflows and their impacts on host galaxies.
Navigating through the Reefs An Engaged Ethno-Archaeology Study of Torres Strait Islander Gidhal
Authors: Wright Duncan , Mitchell Rod , Repu Cygnet 
Published: March 2024

Abstract
For over a century Torres Strait Islander Elders’ accounts about the adventures of reforming ancestors have been recorded. The pathways of these muruygul integrate a chain of Torres Strait islands, neighboring Papua New Guinea, and northern Cape York Peninsula (Australia). According to Islanders, these narratives (each segment of which is owned by different communities) encode important information about cross-community cohesion in the past and present; a mythological geography commemorated through stories, songs, ceremonies, and art. In this chapter, Cygnet Repu describes the process by which he routinely “navigat[es] between the reefs” to “read” these multistage stories, using various cultural data sets. This method of detailed assessment of oral histories, archaeology, and language is applied herein to a gidha (important story, legend, myth) sequence relating to the wandering cultural heroes, Naga and Waiat (Wayath, called Waiet in Meriam Mìr, Waiati in Mawata-Daru Kiwai). We demonstrate how greater than 700-year-old story-line pathways taken by these cultural heroes are marked by transportation of loanwords and songs, artistic endeavors and ceremonial exchange. Excavation results are presented for community-wide celebrations and rites of passage associated with Waiat in Western and Eastern Torres Strait. Finally, we reassess past human activities within this region and the important role living saga traditions may play within broader understanding of saga histories and storytelling.
MORE FLORET1 controls anther development by negatively regulating key tapetal genes in both diploid and tetraploid rice
Authors: Lu Zijun , Zhu Lianjun , Liang Guobin , Li Xiaoxia , Li Qihang , Li Yajing , He Shengbo , Wu Jinwen , Liu Xiangdong , Zhang Jingyi 
Published: March 2024

Abstract
Polyploid hybrid rice (Oryza sativa) has great potential for increasing yields. However, hybrid rice depends on male fertility and its regulation, which is less well studied in polyploid rice than in diploid rice. We previously identified an MYB transcription factor, MORE FLORET1 (MOF1), whose mutation causes male sterility in neo-tetraploid rice. MOF1 expression in anthers peaks at anther Stage 7 (S7) and progressively decreases to low levels at S10. However, it remains unclear how the dynamics of MOF1 expression contribute to male fertility. Here, we carefully examined anther development in both diploid and tetraploid mof1 rice mutants, as well as lines ectopically expressing MOF1 in a temporal manner. MOF1 mutations caused delayed degeneration of the tapetum and middle layer of anthers and aberrant pollen wall organization. Ectopic MOF1 expression at later stages of anther development led to retarded cytoplasmic reorganization of tapetal cells. In both cases, pollen grains were aborted and seed production was abolished, indicating that precise control of MOF1 expression is essential for male reproduction. We demonstrated that 5 key tapetal genes, CYP703A3 (CYTOCHROME P450 HYDROXYLASE 703A3), OsABCG26 (O. sativa ATP BINDING CASSETTE G26), PTC1 (PERSISTENT TAPETAL CELL1), PKS2 (POLYKETIDE SYNTHASE 2), and OsABCG15 (O. sativa ATP BINDING CASSETTE G15), exhibit expression patterns opposite to those of MOF1 and are negatively regulated by MOF1. Moreover, DNA affinity purification sequencing (DAP-seq), luciferase activity assays, and electrophoretic mobility shift assays indicated that MOF1 binds directly to the PKS2 promoter for transcriptional repression. Our results provide a mechanistic basis for the regulation of male reproduction by MOF1 in both diploid and tetraploid rice. This study will facilitate the development of polyploid male sterile lines, which are useful for breeding of polyploid hybrid rice.
Patterns of reproductive health in inflammatory rheumatic diseases and other immune-mediated diseases: a nationwide registry study
Authors: Kerola Anne M , Palomäki Antti , Laivuori Hannele , Laitinen Tarja , Färkkilä Martti , Eklund Kari K , Ripatti Samuli , Perola Markus , Ganna Andrea , Lindbohm Joni V , Mars Nina 
Published: March 2024

Abstract

Objectives
Rheumatic diseases may impair reproductive success and pregnancy outcomes, but systematic evaluations across diseases are lacking. We conducted a nationwide cohort study to examine the impact of rheumatic diseases on reproductive health measures, comparing the impacts with those of other immune-mediated diseases (IMDs).

Methods
Out of all of the 5 339 804 Finnish citizens, individuals born 1964–1984 and diagnosed with any of the 19 IMDs before age 30 (women) or 35 (men) were matched with 20 controls by birth year, sex, and education. We used data from nationwide health registers to study the impact of IMDs on reproductive health measures, such as reproductive success and, for women, ever having experienced adverse maternal and perinatal outcomes.

Results
Several of the rheumatic diseases, particularly SLE, JIA, and seropositive RA, were associated with higher rates of childlessness and fewer children. The risks for pre-eclampsia, newborns being small for gestational age, preterm delivery, non-elective Caesarean sections, and need of neonatal intensive care were increased in many IMDs. Particularly, SLE, SS, type 1 diabetes, and Addison’s disease showed &gt;2-fold risks for some of these outcomes. In most rheumatic diseases, moderate (1.1–1.5-fold) risk increases were observed for diverse adverse pregnancy outcomes, with similar effects in IBD, celiac disease, asthma, ITP, and psoriasis.

Conclusion
Rheumatic diseases have a broad impact on reproductive health, with effects comparable with that of several other IMDs. Of the rheumatic diseases, SLE and SS conferred the largest risk increases on perinatal adverse event outcomes.
Motivation–opportunity–ability–behaviour of community members and program implementers towards mass drug administration for lymphatic filariasis elimination in India: a systematic review and implementation priority
Authors: Sinha Abhinav , Mohapatra Sumegha , Sahoo Krushna Chandra , Mohanty Shubhashisha , Sahoo Banamber , Pati Sanghamitra , Sahoo Prakash Kumar 
Published: March 2024

Abstract
Lymphatic filariasis (LF) is a significant public health issue in India. Despite 10–15 rounds of mass drug administration (MDA) in India, the global LF elimination target of 2030 appears challenging. To strengthen the program, community and provider perspectives on ways to bridge a gap in MDA are needed. Through the motivation–opportunity–ability–behaviour (MOAB) lens, we systematically reviewed the facilitators and barriers encountered in LF elimination in India. We followed Preferred Reporting Items for Systematic Review and Meta-Analysis guidelines. We searched PubMed, Embase, ProQuest and Google Scholar databases to explore factors related to MDA program implementation in India through 30 June 2021. We analysed the data using a thematic framework. We identified 576 studies; of these, 20 studies were included. This review revealed that the public health system for distributing MDA drugs in India created a better enabling environment, including zero out-of-pocket expenditure, door-step distribution of medicines and ample capacity-building training and follow-up. However, community members were unaware of the rationale for drug consumption, leading to a gap in drug distribution and consumption. Motivation is required among community members, which suggests capacity-building training for service providers to counsel the community.
VIPERA: Viral Intra-Patient Evolution Reporting and Analysis
Authors: Álvarez-Herrera Miguel , Sevilla Jordi , Ruiz-Rodriguez Paula , Vergara Andrea , Vila Jordi , Cano-Jiménez Pablo , González-Candelas Fernando , Comas Iñaki , Coscollá Mireia 
Published: March 2024

AbstractViral mutations within patients nurture the adaptive potential of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during chronic infections, which are a potential source of variants of concern. However, there is no integrated framework for the evolutionary analysis of intra-patient SARS-CoV-2 serial samples. Herein, we describe Viral Intra-Patient Evolution Reporting and Analysis (VIPERA), a new software that integrates the evaluation of the intra-patient ancestry of SARS-CoV-2 sequences with the analysis of evolutionary trajectories of serial sequences from the same viral infection. We have validated it using positive and negative control datasets and have successfully applied it to a new case, which revealed population dynamics and evidence of adaptive evolution. VIPERA is available under a free software license at https://github.com/PathoGenOmics-Lab/VIPERA.
Risk Factors and Frequency of Foot Ulceration in Patients Receiving Chronic Hemodialysis Treatment
Authors: Özdemir Vacide Aşik , Nural Nesrin 
Published: March 2024

ABSTRACT

OBJECTIVE
To determine the prevalence and risk factors of foot ulceration in patients receiving hemodialysis treatment.

METHODS
A total of 180 patients who received hemodialysis treatment in two state hospitals and a private health center between April 2017 and September 2017 were included in the study. The researchers collected data using a patient information form and by conducting physical evaluation of the lower extremities. They used the diabetic foot risk assessment algorithm to classify risk according to the data obtained.

RESULTS
Of the patients receiving hemodialysis treatment, 6.7% had foot ulceration, 19.4% had a history of foot ulceration, and 8.3% had a history of hospitalization associated with ulceration in a lower extremity. Infected foot ulceration was the most common (6.1%) cause of hospitalizations. In the group with current or past foot ulceration, diabetic nephropathy was the most common etiologic factor of end-stage kidney disease (48.6%); there was a significant between-group difference in diabetic nephropathy (P < .05). Etiologic factors had a significant effect on foot ulcerations: As determined by univariate logistic regression, diabetes (odds ratio [OR], 2.727; P < .05), presence of neuropathy (OR, 4.208; P < .05), low-density lipoprotein cholesterol (OR, 1.013; P < .05), and serum albumin (OR, 0.302; P < .036) all had a statistically significant effect on the presence of foot ulcerations.

CONCLUSIONS
Patients receiving hemodialysis treatment are at high risk for foot ulceration. Therefore, patient awareness strategies should be expanded to include individuals with end-stage renal disease regardless of diabetes status. Clinical and dialysis nurses should educate these patients about foot ulcerations and foot health to prevent ulcer development.
Exploring the Experiences of Patients with Autoimmune Skin Diseases During the COVID-19 Pandemic
Authors: Dehghan Nayeri Nahid , Fooladzadeh Dehghan Mohsen 
Published: March 2024

ABSTRACT

OBJECTIVE
To explore the experiences of patients with an autoimmune disease during the COVID-19 pandemic.

METHODS
A total of 12 patients with autoimmune skin disease who were hospitalized in dermatology wards between 2021 and 2022 participated in this qualitative study. The researchers conducted in-depth, semi-structured interviews, which they analyzed using conventional content analysis.

RESULTS
Data analysis revealed three main themes: changes in mental/psychological status, social impacts and financial problems, and physical consequences. These patients reported changes in mental/psychological status as their most important experiences.

CONCLUSIONS
During a pandemic, it is important to manage the therapeutic course of patients who are at risk of infection, especially patients with autoimmune skin diseases, via appropriate planning.
Healthcare Utilization Among Adults With Vestibular Vertigo in the United States
Authors: Matthews Jacob C. , Agrawal Yuri , Qian Z. Jason , Wei Eric X. 
Published: March 2024

Objectives:
Vestibular vertigo has been shown to have a high lifetime prevalence. Previous studies have described the increased morbidities associated with vestibular vertigo.

Design:
In this cross-sectional study of the 2016 National Health Interview Study, we sought to explore whether individuals with vestibular vertigo were more likely to utilize healthcare resources compared with those without vestibular vertigo. We characterized utilization of specific healthcare resources including general doctors, specialist doctors, emergency departments, mental health professionals, and others among individuals with vestibular vertigo to better understand how individuals with vertigo interact with the US healthcare system.

Results:
In multivariable analyses, participants with vestibular vertigo had an increased number of nights in the hospital in the last 12 months (mean difference = 0.67 days, 95% confidence interval [CI] = 0.37 to 0.97), increased odds of receiving healthcare 10 or more times in the last 12 months (odds ratio = 2.22, 95% CI = 1.99 to 2.48) and increased number of visits to a healthcare professional in the last 2 weeks (mean difference = 0.17 visits, 95% CI = 0.14 to 0.21). In addition, participants with vestibular vertigo had increased odds of visiting both general doctors, specialist doctors, and other healthcare professionals.

Conclusions:
These findings characterize how individuals with vestibular vertigo utilize and interact with healthcare resources compared with those without vestibular vertigo.
Does Scheduled Low-Dose Short-Term NSAID (Ketorolac) Modulate Cytokine Levels Following Orthopaedic Polytrauma? A Secondary Analysis of a Randomized Clinical Trial
Authors: Foster Jeffrey A. , Hawk Gregory S. , Landy David C. , Griffin Jarod T. , Bernard Andrew C. , Oyler Douglas R. , Southall Wyatt G.S. , Muhammad Maaz , Sierra-Arce Carlos R. , Mounce Samuel D. , Borgida Jacob S. , Xiang Lusha , Aneja Arun 
Published: March 2024

OBJECTIVES:
To determine whether scheduled low-dose, short-term ketorolac modulates cytokine concentrations in orthopaedic polytrauma patients.

METHODS:

Design:
Secondary analysis of a double-blinded, randomized controlled trial.

Setting:
Single Level I trauma center from August 2018 to October 2022.

Patient Selection Criteria:
Orthopaedic polytrauma patients between 18-75 years with a New Injury Severity Score greater than 9 were enrolled. Participants were randomized to receive 15 mg of intravenous (IV) ketorolac every 6 hours for up to 5 inpatient days or 2 mL of IV saline similarly.

Outcome Measures and Comparisons:
Daily concentrations of prostaglandin E2 (PGE2), interleukin (IL)-1a, IL-1b, IL-6, and IL-10. Clinical outcomes included hospital and intensive care unit (ICU) length of stay (LOS), pulmonary complications, and acute kidney injury (AKI).

RESULTS:
Seventy orthopaedic polytrauma patients were enrolled, with 35 participants randomized to the ketorolac group and 35 to the placebo group. The overall IL-10 trend over time was significantly different in the ketorolac group (p = 0.043). IL-6 was 65.8% higher at enrollment compared to Day 3 (p < 0.001) when aggregated over both groups. There was no significant treatment effect for PGE2, IL-1a, or IL-1b (p > 0.05). There were no significant differences in clinical outcomes between groups (p > 0.05).

CONCLUSIONS:
Scheduled low-dose, short-term, IV ketorolac was associated with significantly different mean trends in IL-10 concentration in orthopaedic polytrauma patients with no significant differences in PGE2, IL-1a, IL-1b, or IL-6 levels between groups. The treatment did not have an impact on clinical outcomes of hospital or ICU LOS, pulmonary complications, or AKI.

LEVEL OF EVIDENCE:
Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence.
Distal Femoral Stress Fractures Has High Operation Rates in Adolescent and Young Adult Athletes
Authors: DeFoor Mikalyn T. , Mullin Edmund P. , Cuenca Rachel A. , Pierrie Sarah N. 
Published: March 2024

Background:
Although stress fractures of the distal femur are rare, symptoms can overlap with other peri-articular knee pathology, delaying diagnosis. Untreated stress fractures have the potential to progress into completed fractures with a higher likelihood for requiring surgery and longer recovery times in otherwise healthy adolescents and young adults. This case series represents the largest cohort of adolescent athletes with distal femoral stress fractures who presented with activity-related knee pain.

Methods:
Patients treated nonoperatively and operatively for metaphyseal distal femur stress fractures at a tertiary referral center over a four-year period were retrospectively identified from the medical record.

Results:
Eight patients (mean age 16.8 y; range 14 to 22 y; 87.5% male; mean body mass index [BMI] 20.9) with a total of 10 distal femur stress fractures were identified. All patients were involved in competitive sports or military training. There was an average of 3.8 encounters with a medical provider between presentation with activity-related knee pain and diagnosis with distal femur stress fracture. All except 1 patient (87.5%) were initially incorrectly diagnosed with another type of peri-articular knee pathology. Six stress fractures (60%) were treated conservatively with protected weight bearing, activity modification, and gradual return to activity. Four completed stress fractures (40%) required operative fixation—3 healed uneventfully, while 1 had an asymptomatic delayed union. Vitamin D insufficiency (<30 ng/mL) was identified in 7 of 8 patients (87.5%) and 3 patients (37.5%) had an underweight BMI (<18.5). The mean clinical follow-up was 13.1 weeks (range, 2.8 to 32.0 wk).

Conclusions:
High clinical suspicion for distal femoral stress fractures is needed to avoid misdiagnosis or delayed diagnosis in young, active individuals with activity-related knee pain refractory to conservative management. In this patient population, activity-related knee pain recalcitrant to activity modification, rest, and physical therapy warrants further workup with magnetic resonance imaging and orthopaedic evaluation. Though rare, misdiagnosis can result in catastrophic fractures with prolonged rehabilitation needs. An open line of communication and streamlined access for referral between primary care providers and orthopaedic surgeons is critical in preventing misdiagnosis and delayed treatment. Furthermore, the treatment of concomitant metabolic disorders and nutritional deficiency should not be neglected when treating distal femoral stress fractures.

Level of Evidence:
Level—IV (case series).