bluuebunny/crossref_metadata_2025_split huggingface dataset:
(O-27) PRELIMINARY DATA ON THE USE OF PLATELET-RICH PLASMA IN PENIS FOR ERECTILE DYSFUNCTION OF VASCULAR ORIGIN
Authors: Mayer M , Gioielli A , Valente S 
Published: March 2024

Abstract

Introduction
After conducting an exhaustive review of the literature published to date, we decided to evaluate the effects of acute exposure to autologous PRP on erectile function and assess the impact of this therapeutic strategy in patients with erectile dysfunction of mild-moderate vascular origin.

Materials and methods
All patients who participated in our study completed the IIEF 5 questionnaire prior to the procedure.

Procedure
autologous venous blood was extracted, the sample was processed and activated with 10% calcium chloride solution. After local anesthesia in the trunk of the penis shaft with benzocaine and xylocaine. 8 ml of PRP was applied to 9 patients, with a 25G needle, distributed in 4 applications. 2 applications in each cavernous body, one in the distal region and another in the proximal regionsThe designed protocol indicates: 4 applications spaced by 15 days. The 9 patients complied with all applications.

Results
The average age of the patients was 68.7 years (range 58-77). The IIEF-5 average prior to applications was 14.6.One month after completing the complete protocol, the IIEF-5 score showed a result of 18.9.

Conclusion
This type of procedure, being an autologous treatment and not having relevant complications, could be a promising therapeutic strategy for patients with erectile dysfunction of mild-moderate vascular origin, as long as expectations are explained and health is addressed. integral to avoid the eventual progressive deterioration of the endothelium.

Financing
No conflict.
(O-29) QUALITY OF LIFE AND SELF-ESTEEM IN SPANISH MEN WITH ERECTILE DYSFUNCTION
Authors: Benitez J , Laborda E , Sandoval-Salinas C 
Published: March 2024

Abstract

Introduction
Sexuality is an important aspect for men, so suffering from pathologies such as erectile dysfunction (ED) can affect different areas of their lives beyond sexual health.

Aim
To evaluate the degree of affectation and the factors associated with the self-esteem and quality of life of men with ED.

Methods and patients
Men over 18 years old with ED treated in different cities in Spain participated. The general quality of life (World Health Organization Quality of Life-BREF, WHOQOL-BREF), quality of sexual life (Sexual Life Quality Questionnaire-SLQQ), and the degree of self-esteem (Self-Esteem and Relationship-SEAR) were evaluated, and identified factors associated with these constructs. How ED affects areas and quality of life was qualitatively explored with semi-structured interviews.

Results
356 men participated in the quantitative phase and 21 in the qualitative phase. The average age was 58.2 years old (SD 12.2), 13.2% lived in Madrid, 55.6% worked, 59% lived with their partner, 98% were heterosexual, and 72.2% presented comorbidities related to ED. The mean IIEF was 11.4 (SD 6.6) and the mean time with ED was 5.9 years. In 17.4% the general quality of life was very bad or regular and in 55.3% quite good or very good, with no association found between this value and the quality of the erection or the degree of ED. The average score for the SLQQ questionnaire was 48.7 (SD 1.4) and for the SEAR questionnaire was 36.4 (SD 17.76), with an average score of 37.9 (SD 18.5) on the self-esteem subscale. Time with ED and frequency of sexual relations was associated with low self-esteem and confidence, and the severity of ED was associated with a low score in the social relationships domain (p&lt;0.05). In the qualitative evaluation, few patients considered that ED affects other areas of their lives in addition to their sexual health.

Conclusions
ED can negatively affect the quality of sexual life and self-esteem in Spanish men, but other areas of their lives are not affected.

Financing
Boston Medical Group.
(O-31) ASSOCIATION BETWEEN SEXUAL AGENCY AND SEXUAL SATISFACTION IN BRAZILIAN AND PORTUGUESE UNIVERSITY STUDENTS
Authors: Soster A P , Falcke D , Oliveira A M 
Published: March 2024

Abstract

Aim
This study aimed to verify the association between sexual agency and sexual satisfaction in Portuguese and Brazilian university students.

Method
322 university students, 161 Brazilian and 161 Portuguese, aged between 18 and 29, took part in this cross-sectional study by answering an online questionnaire. The measures used were a sociodemographic questionnaire, the Sexual Attitudes Scale, the New Sexual Satisfaction Scale and the Sexual Assertiveness Scale. The data was analyzed using descriptive statistics and Spearman correlation. Ethical procedures were met.

Results
The measures of individual sexual satisfaction (BR 0.446/PT 0.499), relational sexual satisfaction and in sexual satisfaction of sexual activity (BR 0.375/PT 0.363), and total sexual satisfaction (BR 0.454/PT 0.458), showed significant (p&lt;0.01) moderate positive associations with the dimension of sexual assertiveness initiation, related to sexual agency to initiate sexual relations and communicate desires to the partner in both groups. This is a finding that contradicts the rules associated with traditional sexual scripts, which advocate that women tend to behave passively in relation to their partner's desires.

Conclusion
The association between initiative and sexual satisfaction demonstrates the need to go against traditional sexual scripts, encouraging women to recognize and communicate their desires, and to validate the right to pleasure and sexual satisfaction. Expanding communication and listening to desires, opening up to different ways of giving and receiving physical pleasure, can increase the feeling of desire and the possibility of feeling desired, favoring the possibility of individual and shared pleasure and satisfaction.

Financing
No conflict.
(O-38) SEXUAL FUNCTION OF WOMEN WITH NORMAL WEIGHT, OVERWEIGHT AND OBESITY FROM 18 TO 50 YEARS OLD
Authors: Castiglione M , Silva Cardoso E , De Avila V , Maas Soldi N , Marques Nicastro D , Moura Rodrigues S , Benetti F , Estevão A , Lie Utiyamada N , Glina S 
Published: March 2024

Abstract

Introduction
Female sexual dysfunctions (FSD) can influence physical and mental health, causing limitations in the ability to respond to or enjoy sexual pleasure. Studies show that overweight and obesity can lead to the onset of FSD, but the evidence found remains conflicting.

Objective
To investigate and compare the sexual function of women between 18 and 50 years old, obese, overweight and eutrophic.

Materials and methods
Observational and comparative study. A link to the questionnaire was sent through social networks to women between 18 and 50 years old, sexually active in the last four weeks before answering the questionnaire, after agreeing to participate in the study and signing the consent form, they filled out a form. with demographic data and the Female Sexual Function Index questionnaire, postmenopausal women were excluded from the survey. This study was approved by the ethics and research committee of the FMABC University Center with opinion number: 4,229,411.

Results
325 women participated in the study, with an average age of 28 years, where 186 were classified as obese (49.60%), 109 as overweight (29.07%) and 80 as obese (21.33%, the majority married in a stable union). . union (50.13%) or single (42.93%).In the total score of the FSFI questionnaire (median), non-obese participants obtained 16.4 points, overweight participants obtained 16.4 points, and obese participants they obtained 17.1, without significant difference. in the comparison of DSF according to BMI classification (p=0.887).

Conclusions
There were no statistically significant results on sexual function in obese, overweight and normal weight women in the study.

Financing
No conflict.
(O-40) THERAPEUTIC GROUPS FOR MEN WITH PENILE OR TESTICULAR CANCER
Authors: Silva I M , Naccarato A M E P , Fiolo B , Denardi F , Matheus W E , Ferreira U 
Published: March 2024

Abstract

The incidence of cancer in the world population in 2002 was estimated at 11 million new cases, in 2020 this estimate is approximately 20 million. Cancer is a global public health problem. Testicular cancer (TC) mainly affects men aged 15 to 40 years, and the incidence is about 5/100,000. Typically, tumors are aggressive and cause a great psychological impact on patients.
Penile cancer (PC) represents 2% of all types of tumors that affect men in Brazil. The majority of the affected population are elderly men. Normally the tumor is identified at an advanced stage, when the only available treatment is total or partial penectomy, causing great emotional impact.
This work aims to evaluate the impact of psychotherapy, in an open group, on the Quality of Life Related to Health and Sexuality in patients with CT and CP who have been diagnosed, are undergoing treatment or are being monitored after treatment. Data are collected through an initial interview (Identification, Anamnesis, Health Anamnesis, Degree of Satisfaction with Life and Sexuality, Affective-Emotional Assessment and Treatment Data), SF-36 questionnaire and IIEF-5 short form, in patients who were diagnosed, underwent treatment or are being monitored at the outpatient clinic, and reapplied at the end of 12 sessions. At each session, 5 questions are answered regarding the perception of the previous session. The group is available once a week for 12 weeks. Sessions last 90 minutes, led by the same psychologist.
The research is being developed considering the ethical principles of secrecy, privacy and confidentiality. At the beginning of the process, the Free and Informed Consent Form is delivered as well as details regarding the research. It is also explained that participation is voluntary and that the participant may leave the research at any time, without this affecting their treatment and follow-up.

Financing
No conflict.
(PM-07) EVALUATION OF SEXUAL HEALTH EDUCATION IN THE FACULTY OF MEDICAL SCIENCES OF THE UNIVERSITY OF CAMPINAS: SEXUAL COMMUNICATION IN PATIENT-DOCTOR RELATIONSHIP APPROACH
Authors: Ribeiro M L , Naccarato A , Negreiros M E , Barbuio M E , Silva I m , Matheus W E 
Published: March 2024

Abstract

Introduction/objectives
Sexual dysfunction, present in 43% of women and 31% of men, is the result of several pathological conditions and must be properly investigated and treated. About 50 to 72% of physicians experience difficulty and do not regularly investigate their patients' sexual health.
The study investigates the teaching and approach to sexual health in the medical graduation at the Faculty of Medical Sciences of the State University of Campinas, in order to detect gaps that justify the difficulty in discussing this aspect.

Materials and Methods
Descriptive and transversal study is in progress, including medical students that are above 18 years old and are in the fifth or sixth year of their graduation. Anonymously and after reading the Informed Consent Form, the online questionnaire, composed of questions related to the theoretical and practical approaches in sexuality and the knowledge that they have been receiving in medical school, can be answered.

Results
The online questionnaire was answered by 64 students in the fifth and sixth year of graduation (1.6% and 98.4%, respectively). 43.5% denied being effectively prepared and confident, 35.5% are uncertain and only 21% feel prepared to discuss the subject with their patients.
The main theme approached involves mostly the female sexuality, being the reproductive focus (85.2%), abortion (85.2%) and sexual violence (83.6%) the most discussed subjects. Only 4 students indicate that they understand male dysfunctions. A minority of participants (21.9%) felt safe to address sexual issues with their patients.

Conclusions
Most of the students do not feel comfortable or confident and lack specific knowledge and skills to deal with questions related to sexuality.
More time should be dedicated to education, theoretical and practical classes, concerning human sexuality and its cultural, societal, and health aspects in the graduation during medical school.

Financing
No conflict.
(PM-15) THE EFFECT OF A PELVIC FLOOR TRAINING PROGRAM APPLIED IN PREGNANT WOMEN WITH URINARY INCONTINENCE
Authors: Lohane da Silva Muniz E , Pereira Ribeiro da Silva I , Estevão A , Castiglione M 
Published: March 2024

Abstract

Introduction
Urinary incontinence is a common symptom during pregnancy, the most common type of incontinence in pregnant women is SUI. Stress urinary incontinence affects 54% of all pregnant women. These symptoms are usually experienced during pregnancy and postpartum and can negatively affect quality of life, interfering with social, professional and family activities. Pelvic floor muscle training supervised by a therapist is an effective treatment for UI in women and has been shown to be effective; However, there is still clinical uncertainty about the application of these exercises in pregnant women.

Objective
The objective of this study is to conduct a review of the literature and present the effect of pelvic floor exercise in pregnant women with urinary incontinence, in order to validate whether there are benefits or not.

Methods
An integrative review of the literature was carried out, surveys were carried out in the electronic databases PubMed and PEDro, using the descriptors “Exercise”, “Physical Activities”, “Urinary Incontinence” and “Pregnant Women”. Only randomized clinical trials were selected and the search was carried out between April and May 2022.

Results
71 studies were found, only 10 met the established criteria and agreed with the objective of the present review.

Conclusion
An integrative review of the literature was carried out and it was observed that pelvic muscle training helps reduce urinary incontinence in pregnant women and promotes a better quality of life, without associated risks.

Financing
No conflict.
(PM-17) THE ROLE OF PHOSPHODIESTERASE-5 INHIBITORS IN THE TREATMENT OF COMPLEX PENILE WOUNDS: A CASE REPORT AND LITERATURE REVIEW
Authors: de Oliveira C , Fregonesi A , Costa de Salles L , Chahade Sibanto Simões G , Pereira de Souza A B , Degani Ottaiano A , Canettieri Rubez A , Ricardo Di Domenico B , Franco de Oliveira Júnior F , Akel Ferruccio A , Destro Saad R 
Published: March 2024

Abstract

Introduction/Objective
Phosphodiesterase-5 inhibitors (PDE5i) are traditionally employed for the management of erectile dysfunction and lower urinary tract symptoms. However, their role in the healing of complex penile wounds remains scarcely discussed. This study aims to describe the case of a 27-year-old man who suffered from penile strangulation, treated with sildenafil. Additionally, a literature review concerning the use of PDE5i for the treatment of complex penile injuries will be conducted.

Methods
A 27-year-old man presented to the emergency room after a self-induced penile strangulation using a ring placed at the base of the penis. Extensive necrosis of the corpus cavernosum was identified through magnetic resonance imaging. Considering the psychosocial implications of penile amputation, organ preservation was chosen, and conservative treatment with sildenafil and daily local dressings was initiated. Thirty days after admission, Doppler ultrasound revealed symmetrical corpus cavernosum with normal echogenicity and usual blood flow patterns. Subsequently, the patient underwent superficial necrotic tissue debridement followed by partial skin grafting in a second stage, leading to hospital discharge after 55 days of hospitalization.

Results
PDE5 inhibitors enhance nitric oxide bioavailability, promoting vasodilation and improved tissue oxygenation, thereby facilitating various phases of the healing process. Evidence indicates their benefit in microvascular perfusion in skin and soft tissues. Reports suggest satisfactory outcomes of topical PDE5i application in radiation-induced lesions, implying their role in epidermal cell expansion, reduction of inflammatory infiltrates, enhanced vascularization, and decreased collagen deposition.

Conclusion
This study presents a successful case of sildenafil use in treatment of a complex penile wound, shedding light on an unconventional application of PDE5i.

Financing
No conflict.
(PM-18) EXPLORING THE CONNECTIONS BETWEEN HYPERSEXUALITY AND SEX HORMONE: A PRELIMINARY STUDY IN BRAZILIAN MEN
Authors: O  Ferreira B , Talib L , T  Scanavino M 
Published: March 2024

Abstract

Introduction
Compulsive sexual behavior disorder (CSBD) or hypersexual behavior has gained global attention due to its adverse impact on health. However, there is just a few data on sex hormones of people reporting CSBD/hypersexual behavior.

Objective
Here, we investigate correlations between CSBD/hypersexual behavior and sex hormone in a sample of 34 Brazilian men who met the diagnostic criteria for CSBD/hypersexual disorder.

Methods
After ethical approval, participants provided informed consent and were assessed through the Instrument of Investigation of CSBD Diagnostic Criteria – ICD11, Hypersexual Disorder Screening Inventory (HDSI), Compulsive Sexual Behavior Inventory (CSBI), Sexual Compulsivity Scale (SCS), and Childhood Trauma Questionnaire (CTQ). Additionally, participants' basal blood levels were evaluated.

Results
The sample had a mean age of 38.2 years (SD ± 10.05). The median hormone levels of total testosterone 484 ng/dL [356;560], free testosterone 372 pmol/L [285;472], prolactin 9.50 ng/mL [8.30;13.4], estradiol 23.9 pg/mL [23.9;27.5], SHBG 26.7 nmol/L [21.8;33.5], FSH 4.10 IU/L [2.8;5.3], and LH 2.90 IU/L [2.18;3.85]. Mean scores for HDSI, CSBI, SCS, and CTQ were 23.2 (SD ± 3.80), 66.3 (SD ± 8.26), 33.7 (SD ± 4.14), and 37.6 (SD ± 8.03), respectively. Spearman's correlation analyses showed a positive correlation between total with free testosterone levels (Rho: 0.87); Total testosterone levels with SHBG (Rho: 0.59); a negative correlation between total and free testosterone levels with SCS score (Rho: –0.38; Rho: –0.35, respectively); a negative correlation between LH levels and CTQ total scores (Rho: –0.63); a negative correlation between CSBI with SCS scores (Rho: –0.58).

Conclusion
Our data shows the first exploration between hypersexuality and sex hormones in a Brazilian men sample, supporting previous findings about a relationship of testosterone levels with SCS scores in hypersexual individuals.

Financing
FAPESP.
(PM-19) INSIGHTS INTO THE PATHOPHYSIOLOGY OF HYPERSEXUALITY: A COMPREHENSIVE LITERATURE EXPLORATION
Authors: O  Ferreira B , J  Teixeira B , Talib L , T  Scanavino M 
Published: March 2024

Abstract

Introduction
Hypersexuality or Compulsive Sexual Behavior Disorder (CSBD) is characterized by a spectrum of sexual behaviors and fantasies marked by compulsion, obsession, and impulsivity. The pathophysiology of CSBD remains poorly understood despite the arousing of articles exploring the potential biomarkers associated with hypersexuality.

Objective
We aimed to review the literature regarding the investigation on CSBD pathophysiology from a neuroimaging, neuroendocrine and molecular perspective.

Methods
We raised papers related on neuroimaging, neuroendocrine and molecular biomarkers investigated in individuals that reached diagnosis of CSBD or similar, written in English language in the last 10 years, through PubMed, Scopus, and Web of Science with biomarkers and compulsive sexual behavior/hypersexuality key terms.

Results
Neuroimaging studies revealed the activation of the anterior cingulate cortex, ventral striatum, and amygdala, in individuals with CSBD. Neuroendocrine markers revealed abnormalities in the hypothalamic-pituitary-adrenal (HPA) axis, including elevated adrenocorticotropic hormone (ACTH) levels and non-suppression of dexamethasone. Findings concerning the hypothalamic-pituitary-gonadal (HPG) axis, responsible for sexual function regulation, varied among CSBD individuals, including testosterone and luteinizing hormone (LH) levels. Oxytocin levels have been noted to rise in CSBD individuals and subsequently decrease following psychotherapy. Genetic and epigenetic markers associated with CSBD suggest involvement of addiction-related genes and epigenetic modifications near the corticotropin-releasing hormone (CRH) gene.

Conclusion
Most of the findings point to HPA axis alterations. Molecular analysis is in the beginning, as well as more research on the HPG axis is needed. The exploration of CSBD biomarkers potentially will provide insights into its pathophysiology, diagnosis, and treatment.

Financing
FAPESP.
The Impact of a Pandemic on a Military Oral and Maxillofacial Pathology Biopsy Service
Authors: Miller Trevor E , Dickens Noel E , Rehmel Matthew R , Jones Bradley E , Hamlin Nicholas J , Robbins Quinn C 
Published: March 2024

ABSTRACT

Introduction
Coronavirus disease 2019 (COVID-19) and the resulting societal reaction presented new challenges to the medical community by limiting patient access to care in 2020 and 2021. The Navy Postgraduate Dental School (NPDS) oral and maxillofacial pathology biopsy service is dependent on in-office physician or dentist appointments and patient biopsies. The purpose of this study was to understand the regulatory and societal impacts of COVID-19 restrictions on biopsy service submissions by assessing NPDS biopsy submission quantities and disease distribution.

Materials and Methods
All NPDS oral and maxillofacial pathology biopsy submissions from calendar years 2015 to 2016 and 2019 to 2021 were evaluated, and patient demographics and biopsy diagnoses were recorded in a biopsy registry. Data collected included age, sex, biopsy site, and diagnosis. Data from 2015, 2016, and 2019 were defined as pre-COVID and 2020 and 2021 as COVID. Biopsy reports for each year were organized in quarters. Diagnoses were categorized as malignant, pre-malignant, or benign. Categorical and continuous data were evaluated and presented as counts with percentages and means or medians with standard deviations, respectively. Significant differences in proportions or means were assessed using chi-square analysis or Student t-test, respectively. Cases were aggregated by quarter and year and assessed for temporal trends using linear regression analysis.

Results
The study evaluated 9,351 biopsy submission reports. The annual pre-COVID count mean (± standard deviation) and yearly counts for 2020 and 2021 were 2,063 ± 33.3, 1,421, and 1,742, respectively. The mean (± standard deviation) percentage of diagnoses classified as malignant from pre-COVID, 2020, and 2021 were 2.46 ± 0.005%, 3.59%, and 3.04%, respectively. Case counts and representation as a percentage of all biopsy diagnoses for Human Papillomavirus (HPV)-associated squamous cell carcinoma increased significantly during COVID compared to pre-COVID years (P &lt; .05).

Conclusions
Overall, preventative COVID-19 health measures and protocols resulted in a reduction in biopsy submission frequency, particularly during the second quarter (April to June) of 2020. However, case counts for malignant biopsies remained consistent between pre-COVID and COVID time intervals, suggesting that the identification and analysis of cases requiring follow-on care were unaffected by COVID-19 protocols.