bluuebunny/crossref_metadata_2025_split huggingface dataset:
Glucocorticoid-induced hyperglycemia (GIH) in pemphigus vulgaris patient at Bangli District General Hospital: A case report
Authors: Ni Kadek Setyawati  , A. A. I. A. Nindya Sari  , Pande Agung Mahariski  
Published: March 2024

Background: Pemphigus vulgaris (PV) is an autoimmune disease characterized by mucocutaneous blistering and erosion. This is rare, but greatly affects the patient’s life quality and often cause complication of disease and therapy. Hyperglycemia is a complication due to steroid use called glucocorticoid-induced hyperglycemia (GIH). This case report describes hyperglycemia in PV treatment, which later can be a consideration of PV management.
Case: A 44-year-old male patient complained of painful lesions on almost the whole body with a form of bullae, erosion, crusting, brittle, the Nikolsky sign (+), and Asboe-Hansen sign (+). The patient was diagnosed with PV. After he had supportive therapy and high-doses of methylprednisolone, his blood sugar is increased. Patients diagnosed by hyperglycemia state due to steroid use, then given insulin as therapy. The patient diagnosed with PV based on history taking and physical examination, but the histopathologic examination wasn’t done due to lack of modality at the hospital. The steroid was given as an immunosuppressive. Be the main therapy for PV, steroids lead hyperglycemia due to disruption of glucose metabolism, thereby increasing insulin resistance in tissues. The diagnosis of hyperglycemia due to steroid use is made in a patient with a normal sugar level before PV therapy. It occurred within the first 1-2 days of therapy. In these patients, diagnosis confirmed by increasing pre-prandial, 2 h post-prandial, and any-time glucose level, after two days methylprednisolone administration. Collaboration with internal medicine colleagues is needed.
Conclusion: PV treatment with steroids can induce hyperglycemia, which is dangerous. The understanding mechanism is needed to make early detection and provide therapy properly.
Focus on the dabrafenib, vemurafenib, and trametinib in the clinical outcome of melanoma: A systematic review and meta-analysis
Authors: Ida Ayu Widya Anjani  , Anak Agung Bagus Putra Indrakusuma  , I Gede Krisna Arim Sadeva  , Putri Ayu Wulandari  , Luh Made Mas Rusyanti  , Prima Sanjiwani Saraswati Sudarsa  , I Gede Putu Supadmanaba  , Desak Made Wihandani  
Published: March 2024

Background: Melanoma is the most severe lethal skin cancer, affecting melanin producer cells (melanocytes). Surgery is the most common treatment, whereas, for the advanced stage, the development of treatment is recommended. BRAF (Dabrafenib and Vemurafenib) inhibitor or MEK inhibitor (Trametinib) is the most frequently targeted melanoma therapy due to more than 80% of patients with positive BRAF mutation. In this review, those treatments will be investigated systematically to identify their clinical outcome.
Method: This systematic literature review (SLR) was performed from Cochrane, Science Direct, Google Scholar, and Pubmed. Cochrane Risk-of-Bias Tool RoB2 is used to assess RCT studies and New-castle Ottawa Scale Assessment to assess cohort studies by three different assessors. Data analysis was carried out by using Review Manager (RevMan 5.4). Heterogenicity test was assessed by I2 and Chi2 statistic
Result: There are 20 studies used in this article (13 RCT and seven cohorts). The overall survival (OS) and progression-free survival (PFS) of the survey that using targeted therapy (vemurafenib, trametinib, or dabrafenib) compare other treatments (chemotherapy, immunotherapy, etc.) showed risk ratio (RR) was 1.12 (95%CI 1.07,1.17; I2=100%; p<0,00001). The OS and PFS with monotherapy compare of vemurafenib, trametinib, or dabrafenib with combination therapy showed RR was 1.09 (95%CI.06,1.13; I2=99%; p<0,00001).
Conclusion: BRAF and MEK targeted therapy has a good prognosis for a patient with a positive BRAF gene mutation and could be combined with other treatments for better clinical outcomes rather than monotherapy.
Secondary syphilis with stage III HIV in an adolescent deaf male with a history of sexual relationship with men: a case report
Authors: Tritya Mudita  , Ni Made Dwi Puspawati  , I Gusti Ayu Agung Sattwika  , Andrew Yoshihiro Wirya  
Published: March 2024

Introduction: Syphilis is an infection caused by Treponema pallidum of the spirochaete family.
Case: A 19-year-old Balinese came with a complaint of red spots on the palms of the hands and feet one month ago. The patient has a hearing disability and is currently enrolled in a special-needs school in Denpasar. VDRL examination with reactive results with titer 1:256 and TPHA reactive with TPHA titer 1:5120. The patient received benzathine penicillin G 2.4 million units intramuscularly. Significant improvement was obtained, and the serological test was decreased.
Discussion: Syphilis transmits through sexual contact, vertically from pregnant women to their fetuses, through needle sharing. People with hearing disabilities and adolescents are considered vulnerable as objects of harassment and sexual violence.
Conclusion: People with disabilities and adolescents are vulnerable to sexually transmitted diseases. Information on reproductive health and sexually transmitted diseases need to be more readily available for people with disabilities. Secondary syphilis therapy with a single dose of benzathine penicillin is effective from clinical or serological observations.
Low plasma level of insulin-like growth factor – I (IGF-I) is a risk factor for multibacillary type of leprosy
Authors: Luh Made Mas Rusyati  , Made Swastika Adiguna  , Indra Teguh Wiryo  
Published: March 2024

Introduction: Leprosy is one of infectious diseases with complex issues. The previous study showed poverty, malnutrition, lack of proper food and nutrient intake, as well as low income. Recently, many studies reported insulin-like growth factor-I (IGF-I) as an excellent nutrient marker.
Objective: This study aims to prove that low plasma level of insulin-like growth factor-I is a risk factor for the multibacillary type of leprosy.
Material and methods: This case-control study design involved 38 patients with leprosy subjects as cases and 38 control subjects. The sample collection is done by consecutive sampling and has fulfilled the inclusion and exclusion criteria, which matched by age and gender in Dermatovenereology Polyclinic of Sanglah Hospital. The collected data was analyzed using SPSS version 23.0 with Pearson Chi-square test to obtain the odds ratio.
Results: This study showed that IGF-I plasma levels in the case group were significantly lower than the control group (p<0,05) with Odds ratio for IGF-I plasma 34,61 (95% CI= 7,17-167,01, p<0,001)
Conclusion: Low plasma level of insulin-like growth factor-I is a risk factor for the multibacillary type of leprosy.
Identification of stratospheric disturbance information in China based on the round-trip intelligent sounding system
Authors: He Yang , Zhu Xiaoqian , Sheng Zheng , He Mingyuan 
Published: March 2024

Abstract. Assessing the role of physical processes in the stratosphere under climate change has been one of the hottest topics over the past few decades. However, due to the limitations of detection techniques, stratospheric disturbance information from in situ observations is still relatively scarce. The round-trip intelligent sounding system (RTISS) is a new detection technology, developed in recent years, that can capture atmospheric fine-structure information about the troposphere and stratosphere via three-stage (rising, flat-floating, and falling) detection. Based on the structure function and singular measure relationships, we quantify stratospheric small-scale gravity waves (SGWs) over China, using the Hurst and intermittency parameters, and discuss their relationship with inertia-gravity waves (IGWs). The results show that the enhancement of SGWs in the stratosphere is accompanied by weakening of the IGWs below, which is related to the Kelvin–Helmholtz instability (KHI), and is conducive to the transport of ozone to higher altitudes from lower stratosphere. The parameter space (H1, C1) shows sufficient potential in the analysis of stratospheric disturbances and their role in material transport and energy transfer.
Version 8 IMK/IAA MIPAS measurements of CFC-11, CFC-12, and HCFC-22
Authors: Stiller Gabriele P. , von Clarmann Thomas , Glatthor Norbert , Grabowski Udo , Kellmann Sylvia , Kiefer Michael , Laeng Alexandra , Linden Andrea , Funke Bernd , García-Comas Maya , López-Puertas Manuel 
Published: March 2024

Abstract. The Michelson Interferometer for Passive Atmospheric Sounding (MIPAS) on Envisat provided infrared limb emission spectra, which were used to infer global distributions of CFC-11, CFC-12, and HCFC-22. Spectra were analysed using constrained non-linear least-squares fitting. Changes with respect to earlier data versions refer to the use of version 8 spectra, the altitude range where the background continuum is considered, details of the regularization and microwindow selection, and the occasional joint fitting of interfering species, the use of new spectroscopic data, the joint fit of a tangent-height-dependent spectral offset, and the use of 2D temperature fields. In the lower stratosphere the error budget is dominated by uncertainties in spectroscopic data, while above this measurement noise is the leading error source. The vertical resolution of CFC-11 and CFC-12 is 2–3 km near the tropopause, about 4 km at 30 km altitude, and 6–10 km at 50 km. The vertical resolution of HCFC-22 is somewhat coarser, 3–4 km at the tropopause and 10–12 km at 35 km altitude. In the altitude range of interest, the horizontal resolution is typically limited by the horizontal sampling of the measurements, not by the smearing of the retrievals. Horizontal information displacement does not exceed 150 km, which can become an issue only for comparisons with model simulations with high horizontal resolution or localized in situ observations. Along with the regular data product, an alternative representation of the data on a coarser vertical grid is offered. These data can be used without consideration of the averaging kernels. The new data version provides improvement with respect to reduction of biases and improved consistency between the full- and reduced-resolution mission period of MIPAS.
Regional assessment and uncertainty analysis of carbon and nitrogen balances at cropland scale using the ecosystem model LandscapeDNDC
Authors: Sifounakis Odysseas , Haas Edwin , Butterbach-Bahl Klaus , Papadopoulou Maria P. 
Published: March 2024

Abstract. The assessment of cropland carbon and nitrogen (C and N) balances plays a key role in identifying cost-effective mitigation measures to combat climate change and reduce environmental pollution. In this paper, a biogeochemical modelling approach is adopted to assess all C and N fluxes in a regional cropland ecosystem of Thessaly, Greece. Additionally, the estimation and quantification of the modelling uncertainty in the regional inventory are realized through the propagation of parameter distributions through the model, leading to result distributions for modelling estimations. The model was applied to a regional dataset of approximately 1000 polygons, deploying model initializations and crop rotations for the five major crop cultivations and for a time span of 8 years. The full statistical analysis on modelling results (including the uncertainty ranges given as ± values) yields for the C balance carbon input fluxes into the soil of 12.4 ± 1.4 t C ha−1 yr−1 and output fluxes of 11.9 ± 1.3 t C ha−1 yr−1, with a resulting average carbon sequestration of 0.5 ± 0.3 t C ha−1 yr−1. The averaged N influx was 212.3 ± 9.1 kg N ha−1 yr−1, while outfluxes of 198.3 ± 11.2 kg N ha−1 yr−1 were estimated on average. The net N accumulation into the soil nitrogen pools was estimated to be 14.0 ± 2.1 kg N ha−1 yr−1. The N outflux consists of gaseous N fluxes composed of N2O emissions of 2.6 ± 0.8 kg N2O–N ha−1 yr−1, NO emissions of 3.2 ± 1.5 kg NO–N ha−1 yr−1, N2 emissions of 15.5 ± 7.0 kg N2–N ha−1 yr−1 and NH3 emissions of 34.0 ± 6.7 kg NH3–N ha−1 yr−1, as well as aquatic N fluxes (only nitrate leaching into surface waters) of 14.1 ± 4.5 kg NO3–N ha−1 yr−1 and N fluxes of N removed from the fields in yields, straw and feed of 128.8 ± 8.5 kg N ha−1 yr−1.
Harmonized European Union subnational crop statistics can reveal climate impacts and crop cultivation shifts
Authors: Ronchetti Giulia , Nisini Scacchiafichi Luigi , Seguini Lorenzo , Cerrani Iacopo , van der Velde Marijn 
Published: March 2024

Abstract. The availability of coherent time series of crop statistics is essential for better analyzing the past, understanding the present, and predicting future trends in yield, area, and production. Importantly, such data also underpin assessments and subsequent policy actions that can shape future food systems that are more resilient in the face of climate change and that are sustainable in terms of resource use efficiency. In the European Union (EU), there currently is no legal obligation for EU countries to provide subnational crop statistics. However, such data could improve in-season crop forecasts, climate change impacts and adaption need assessments, and evaluation of agri-environmental schemes. The dataset described in this paper includes a harmonized collection of subnational crop statistics on area, production, and yield, collected for the EU from National Statistical Institutes (NSIs) and the EUROSTAT REGIO database – subnational crop statistics voluntarily contributed by EU countries. The crops considered are wheat (including soft and durum wheat), barley (including winter and spring barley), grain maize, sunflower, and sugar beet. All data are harmonized towards the hierarchical structure of the EUROSTAT legend and the regional classification of NUTS (Nomenclature of Territorial Units for Statistics) version 2016, to provide coherent time series. A total of 344 282 records is presented here (115 974 for wheat, 122 705 for barley, 35 274 for grain maize, 34 916 for sugar beet, and 35 413 for sunflower) for a total of 961 regions in 27 EU countries. Statistics are reported from 1975 to 2020, with a median time-span range of 21 years. A flagging system details, for each data record, information on data sources, processing steps, and quality-checking results. This includes consistency checks between reported values for area, yield and production, identification of null values, missing and calculated data, information on crop legend matching, and NUTS versioning. We illustrate the value of this dataset by analyzing impacts on crops and production zone shifts in Europe due to climatic and economic factors. Recommendations and future developments of collecting subnational statistics at the EU level are briefly discussed. The dataset is accessible with European Commission Authentication Service (ECAS) login at https://doi.org/10.2905/685949ff-56de-4646-a8df-844b5bb5f835 (Ronchetti et al., 2023b).
QUALITY PROPERTIES OF GLUTEN-FREE BOZA PRODUCED WITH BUCKWHEAT (Fagopyrum esculentum) AND TEFF (Eragrostis tef) FLOUR
Authors: GÖNCÜ Ali , KUZUMOGLU Yasemin , ÇELIK Ilyas , YILDIRIM VARDIN Asli 
Published: March 2024

Boza is a traditional Turkish fermented cereal beverage and typically can be produced from wheat, corn, rice, or millet. This paper aims to significant contribution to the limited availability of gluten-free boza. Gluten-free boza was obtained from buckwheat and teff flour as natural gluten-free ingredients, instead of wheat flour in this study. The results showed that gluten-free boza has more dietary fiber, protein, potassium, magnesium, manganese, phosphorus, and zinc. Substituting gluten-free flour decreased the boza’s viscosity, yet this decrease did not affect the sensory analysis results (p> 0.05). Also, the results of microbiological analyses of boza demonstrated that BUB had the highest number of LABs of all the gluten-free boza. According to the results of the sensory analysis, panelists rated the gluten-free boza with buckwheat and teff flour highest in terms of flavor and general taste characteristics. We conclude that these gluten-free flours can be effectively used in boza production.
PENYULUHAN TENTANG PENANGANAN STROKE HEMORAGIK
Authors: Merry Merry 
Published: March 2024

Kegiatan webinar kefarmasian merupakan salah satu program pengabdian kepada masyarakat yang dilakukan oleh mahasiswa Apoteker Universitas 17 Agustus 1945 Jakarta secara daring karena terkendala pandemik COVID-19. Pengabdian kepada masyarakat ini bertujuan agar dapat memberikan informasi dan mengaplikasikan ilmu yang didapatkan kepada masyarakat mengenai penyakit “Stroke Hemoragik”.Kegiatan ini dilakukan dengan memanfaatkan teknologi digital, yaitu Zoom Meeting dengan total pendafrat 139 orang. Webinar ini dilaksanakan pada tanggal 15 November 2021 pukul 09:00 Wib sampai 10:30 Wib. Metode kegiatan : Penyuluhan acara webinar online ini berbentuk penyampaian materi dan pencegahan penyakit Stroke Hemoragik dengan metode presentasi melalui zoom meeting. Indikator keberhasilan dari webinar ini didapat dari hasil perbandingan antara pengisian pre-test dan pengisian post test melalui google form oleh peserta. Hasil : Peserta mengikuti webinar kefarmasian tentang “Stroke Hemoragik” dengan aktif dan sangat antusias sampai dengan selesai. Farmasis memiliki peran penting untuk memberikan informasi mengenai penyakit stroke hemoragik yang diharapkan dapat mencegah dan mengurangi faktor penyebab stroke hemoragik. Kiranya semua materi yang diberikan dapat bermanfaat bagi kita semua. Kata kunci : Jurnal pengabdian, Stroke Hemoragik
PENYULUHAN PERILAKU HIDUP BERSIH DAN SEHAT (PHBS) DI WARGA RW 04 KELURAHAN KALIBARU KECAMATAN CILINCING JAKARTA UTARA
Authors: Christian Yulius Evan , Sari Dini Permata 
Published: March 2024

ABSTRACTPHBS is a health behavior that is carried out on awareness so that family members help themselves in the field of health and play an active role in health activities in the community. It is one of the main pillars of a healthy Indonesia and is one of the strategies to reduce the burden on the state, government, and society towards health financing. Healthy conditions can be achieved by changing behavior from unhealthy to healthy and creating a healthy environment; therefore, health needs to be maintained and improved by every member of the household and fought for by all parties. But at this time, there are still many who are attacked by disease due to not implementing clean and healthy living behaviors in the household. The purpose of the study was to determine the level of community knowledge about clean and healthy living behaviors in households. This socialization activity amounted to 19 adults aged 25–60 years in RW 04 Kalibaru Village, Cilincing, North Jakarta. The method of this activity is carried out by means of material presentation, discussion, question and answer, pre-test, and post-test. The results of filling out the pre-test and post-test obtained pre-test results of 61.60% and post-test results of 83.00%. Based on the results of the activity, it can be concluded that there was an increase in the knowledge of the participants, which can be seen from the results of the pre-test and post-test. There was an increase in results from 61.60% to 83.00%. Keywords: Healthy living; Health; Behavior; PHBS
КЫТАЙ ТИЛИНДЕГИ ЖАПАЙЫ КАНАТТУУЛАРГА БАЙЛАНЫШКАН ФРАЗЕОЛОГИЯЛЫК БИРДИКТЕРДИ КЫРГЫЗ ТИЛИНЕ КОТОРУУ МАСЕЛЕЛЕРИ
Authors: Аманбек кызы Нурпейил , Бекмурзаева Асел , Эмильбекова Эльдана 
Published: March 2024

Макалада фразеологизмдерди кытай тилинен кыргыз тилине которуудагы метафораларды жана фразеологиялык бирдиктерди берүү ыкмалары талданат. Тактап айтканда кытай тилинде кездешкен жапайы канаттууларга байланыштуу фразеологизмдердин кыргыз тилине которулушу жана кыргыз тилиндеги эквивалентин аныктоо маселеси каралат. Андан сырткары кытай жана кыргыз элдеринин тил казынасындагы жапайы канаттууларга байланышкан фразеологиялык бирдиктердин окшоштугу жана алардын улуттук өзгөчөлүктөрү каралды.
Effect of Cyanobacteria-Enriched Compost on Maize (Zea mays. L) Growth and Yield and Nutrient Uptake in Inceptisols
Authors: Oktaviyani Trias , Tamad Tamad , Purwani Jati 
Published: March 2024

Increased production of food crops has various obstacles, including soil fertility, which is also caused by the price of inorganic fertilizers, which is burdensome for farmers. Organic and biofertilizers can reduce the use of inorganic fertilizers and the level of degradation of soil fertility. The research was conducted in the greenhouse of Indonesia Soil Research Institute in Bogor from October 2021 to March 2022. The treatments were laid out in a randomized block design consisting of 12 treatments with three replications, consisting of level doses of NPK combined with compost, cyanobacteria, and (Cyanobacteria-enriched compost). (NPK75%+compost) treatment gave the highest corn cobs and grain yield by 209.86 g plant-1 (8.55%) and 163.49 g plant-1 (6.42%), respectively compared to NPK100%. The treatment of (NPK75%+compost) gave a similar grain yield with 100% NPK and can scale down NPK used by 25%. (NPK50%+cyanobacteria-enriched compost) treatment increased N uptake by 48.81% compared to NPK100%. The treatment of (NPK50%+cyanobacteria-enriched compost) increased P uptake by 0.8 mg plant-1 or 17.0% compared to NPK50%+compost. At NPK50%+cyanobacteria, K uptake increased by about 31.46% compared to NPK50%.
Crianças e adolescentes: olhar sobre a pobreza, a qualidade de vida e o bem-estar subjetivo
Authors: Abate Elizabete Aparecida Bragatto , Stoltz Tania , D’Aroz Marlene Schüssler , Asinelli-Luz Araci , Bianchi Alessandra Sant’Anna 
Published: March 2024

Acredita-se que a posição do indivíduo na vida, especialmente no contexto cultural e nos sistemas de valores, define a sua qualidade de vida e bem-estar. Investigou-se a qualidade de vida e o bem-estar subjetivo de crianças e adolescentes entre 10 e 12 anos, socioeconomicamente desfavorecidos, e a sua percepção de pobreza. Trata-se de estudo Quanti-Quali, utilizando o questionário Kidscreen-52 e entrevista acerca do entendimento sobre pobreza. Realizou-se análise estatística descritiva (quantitativo) e foram criadas categorias considerando as entrevistas (qualitativo). Nos resultados do Kidscreen-52, as dimensões sentimentos e auto percepção tiveram as maiores pontuações, indicando bons sentimentos e satisfação em relação a si mesmos. Em contrapartida, a dimensão estado emocional teve o menor valor, sendo maior apenas que aspectos financeiros. Ainda assim, os resultados mostram que os participantes quase sempre estão bem emocionalmente, embora o desvio padrão elevado indique uma oscilação importante na amostra, uma vez que o menor resultado está relacionado com o sentimento de tristeza. Quanto à percepção de pobreza, foram encontradas três categorias: a aparência exterior determina a condição financeira ou de vida; a identificação com o outro está relacionada à aparência externa e o consumo diferencia o rico do pobre. Os participantes avaliaram as situações de pobreza e riqueza, considerando suas impressões do mundo, algumas vezes, movidos por estereótipos e, outras, pela própria observação das condições de vida, as quais estão submetidos; conseguem visualizar situações positivas em suas vidas, como o convívio com os pais e o sustento atendido por eles, observando-os como principal meio para conquistar aquilo que desejam. Concluiu-se que a qualidade de vida e o bem-estar subjetivo de crianças e adolescentes estão relacionados à percepção da pobreza, sendo necessário um novo olhar que valorize os aspectos físicos, econômicos e psicológicos, baseado na percepção dos próprios protagonistas.