bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Subsurface Structure of the Kīlauea Caldera Before Its 2018 Collapse Inferred From Ground Magnetic, SP, and Temperatures Anomalies
Authors: Gailler Lydie , Bouligand Claire , Kauahikaua Jim , Lénat Jean‐François , Cluzel Nicolas 
Published: April 2024

AbstractThe 2018 crisis of Kīlauea volcano stands as a major event in its evolution with a large down‐rift effusive eruption that drained a shallow magma reservoir at the summit. The characterization of such active magmatic systems and associated hazardous events remains a necessity and a challenge. The summit area is hydrothermally active and strongly altered as indicated by geological mapping. A unique data set of geophysical measurements was collected around Halemaʻumaʻu crater before its collapse. Magnetic data are interpreted here in combination with geological information, temperature anomalies at the surface, self‐potential measurements, and a model of electrical conductivity. 3D forward modeling shows that the main magnetic dipole‐like anomaly observed around the crater is not only caused by the crater topography but suggests the presence of an important volume of weakly magnetic material beneath the crater, which may be caused by higher temperature and/or hydrothermal alteration. 3D inversion of the data allows us to explore the first order geometry of the magnetic structures. We complement this inversion with 2D forward modeling in order to refine the geometry of major structures. This study shows the presence of major geological structures in the 2018 collapsed area that may have been associated with mechanical weaknesses and could have played a role in the geometry of the collapse. Therefore, mapping magnetic anomalies and monitoring their temporal evolution are of great interest for constraining the nature and mechanical properties of the underlying formations and their temporal evolution in order to help predict future behavior.
Mineralogical Characterization of the Lunar South Polar Region: 1. The Artemis Exploration Zone
Authors: Moriarty D. P. , Petro N. E. 
Published: April 2024

AbstractThe lunar south pole is a region of focused scientific and exploration interest, with several crewed and robotic missions to this region planned within the next decade. Understanding the mineralogy of the region is essential to inform landing site characterization and selection and provides the key context for interpreting samples and in situ observations. At high latitudes, extreme illumination conditions (high phase angles) can negatively impact the data quality of orbital instruments. This is especially true for passive near‐infrared spectrometers such as the Moon Mineralogy Mapper (M3) and the Kaguya Spectral Profiler, which measure the spectral properties of the surface using reflected sunlight. Using Moon Mineralogy Mapper data, we observed that the south polar region is associated with a detectable mafic signature consistent with the presence of pyroxenes. The strongest mafic signatures are associated with the South Pole—Aitken Basin, suggesting that impact melt and basin ejecta from the lower crust and upper mantle are present within this region. This observation is validated in several ways: (a) comparisons between M3 data acquired during different mission phases, (b) comparisons between multiple spectral parameters sensitive to the presence of mafic minerals, (c) comparisons between the north and south lunar polar regions, and (d) comparisons with publicly available Kaguya polar mineralogy maps and Lunar Prospector elemental abundances. We also investigate the nature of an anomalous high‐albedo region within 2–3° of the south pole observed in Lunar Orbiter Laser Altimeter reflectance data exhibiting a spatially conflicting apparent FeO abundance pattern between several data sets.
Autocalibration of the E3SM Version 2 Atmosphere Model Using a PCA‐Based Surrogate for Spatial Fields
Authors: Yarger Drew , Wagman Benjamin Moore , Chowdhary Kenny , Shand Lyndsay 
Published: April 2024

AbstractGlobal Climate Model tuning (calibration) is a tedious and time‐consuming process, with high‐dimensional input and output fields. Experts typically tune by iteratively running climate simulations with hand‐picked values of tuning parameters. Many, in both the statistical and climate literature, have proposed alternative calibration methods, but most are impractical or difficult to implement. We present a practical, robust, and rigorous calibration approach on the atmosphere‐only model of the Department of Energy's Energy Exascale Earth System Model (E3SM) version 2. Our approach can be summarized into two main parts: (a) the training of a surrogate that predicts E3SM output in a fraction of the time compared to running E3SM, and (b) gradient‐based parameter optimization. To train the surrogate, we generate a set of designed ensemble runs that span our input parameter space and use polynomial chaos expansions on a reduced output space to fit the E3SM output. We use this surrogate in an optimization scheme to identify values of the input parameters for which our model best matches gridded spatial fields of climate observations. To validate our choice of parameters, we run E3SMv2 with the optimal parameter values and compare prediction results to expertly‐tuned simulations across 45 different output fields. This flexible, robust, and automated approach is straightforward to implement, and we demonstrate that the resulting model output matches present day climate observations as well or better than the corresponding output from expert tuned parameter values, while considering high‐dimensional output and operating in a fraction of the time.
Effect of pH on Spontaneous Imbibition in Calcareous Rocks
Authors: Pratama Muhammad Andiva , Khan Hasan Javed 
Published: April 2024

AbstractReactive transport in porous media exhibits multifaceted interactions that are dependent on the matrix and fluid properties, and which ultimately alter these properties. A set of calcareous rock samples with unique mineralogy and varying petrophysical properties are selected for this study. A capillary rise experiment is performed in each sample, first with deionized water and then with a dilute, pH 2, HCl solution. Pre‐ and post‐acid petrophysical properties such as porosity, permeability, pore size distribution, and contact angle are measured for each sample along with the capillary rise profile. The latter is tracked by applying image analysis on video recording. The rock mineralogy significantly affects the acidic fluid intrusion into the rock samples. Calcite dissolution is the main reaction that results in the opening of the pore space. This is more prominent in all the carbonate samples where a higher proportion of calcite minerals is present. A higher capillary rise is consistently observed compared to the neutral fluid along with an increase in porosity and the mean pore size. The contact angle also undergoes changes making the carbonate matrix from oil‐wet to neutral‐wet. Coupling capillary interactions with fluid reactivity is often neglected in fluid transport phenomena. This study offers new insights into the relative importance of reactivity at the timescale of spontaneous imbibition. This is important in understanding dissolution and precipitation processes during capillary flow.
Synoptic Moisture Intrusion Provided Heavy Isotope Precipitations in Inland Antarctica During the Last Glacial Maximum
Authors: Kino K. , Cauquoin A. , Okazaki A. , Oki T. , Yoshimura K. 
Published: April 2024

AbstractStable water isotopes in inland Antarctic ice cores are powerful paleoclimate proxies; however, their relationship with dynamical atmospheric circulations remains controversial. Using a water isotope climate model (MIROC5‐iso), we assessed the influence of the Last Glacial Maximum (LGM; ∼21,000 years ago) sea surface temperatures (SST) and sea ice (SIC) on Antarctic precipitation isotopes (δ18Op) through atmospheric circulation. The results revealed that the synoptic circulation mostly maintained southward moisture transport, reaching inland Antarctica. The steepened meridional SST gradient in the mid‐latitudes increased δ18Op in inland Antarctica with the enhanced baroclinic instability and synoptic moisture transport. In contrast, expanded SIC distribution decreased δ18Op over Antarctica by enhanced preferential removal of heavy isotopes during vapor transport due to the increased transport distance and enhanced surface cooling. These findings propose to use Antarctic ice cores to describe the southern hemisphere atmospheric circulation, represented by the westerly jets, during the LGM and other past climates.
Reply to Comment by Poppema and Wüthrich on “Momentum and Energy Predict the Backwater Rise Generated by a Large Wood Jam”
Authors: Follett Elizabeth , Schalko Isabella , Nepf Heidi 
Published: April 2024

AbstractFollett et al. (2020, https://doi.org/10.1029/2020gl089346) demonstrated that a large wood jam can be modeled as a porous obstruction with momentum loss proportional to the number, size, and packing density of the logs and jam length. Poppema and Wüthrich (2024, https://doi.org/10.1029/2023gl106348) incorporated uniform flow Froude number, broadening the scope of our work. Here, we demonstrate that Froude number can be directly introduced to equations in the main body of Follett et al. (2020, https://doi.org/10.1029/2020gl089346), without requiring uniform flow. Based on this, we show that a managed increase in upstream depth is possible for conditions below a critical discharge, in which equilibrium upstream depth over uniformly distributed jams can be adjusted with inter‐jam spacing. This design could retain water in low flow conditions, allowing jams to act independently above critical discharge. Finally, we suggest that log orientation can be included in our model by varying both drag coefficient and frontal area perpendicular to the flow.
Organic and Inorganic Carbon Sinks Reduce Long‐Term Deep Carbon Emissions in the Continental Collision Margin of the Southern Tibetan Plateau: Implications for Cenozoic Climate Cooling
Authors: Wang Yingchun , Quan Sanyu , Tang Xin , Hosono Takahiro , Hao Yinlei , Tian Jiao , Pang Zhonghe 
Published: April 2024

AbstractThis paper aims to update our understanding of the carbon cycle in the Himalayas, the most intense collisional orogeny globally, by providing new insight into its impact on Cenozoic climate cooling through the use of isotopic variations in both organic and inorganic carbon and an isotopic mass balance model. Our results from 20 selected hot springs show that the relative contributions of dissolved carbon from the mantle, metamorphic decarbonization, aqueous dissolution, and soil organic matter are approximately 2%, 82%, 6%, and 10%, respectively. Approximately 87% ± 5% of CO2 generated in the deep crust precipitates as calcite, while approximately 5.5% ± 1% of this carbon is converted to biomass through microbial chemosynthesis at depths less than 2 km. Our random forests approach yielded a metamorphic carbon flux from the entire Himalayan orogenic belt of approximately 2.7 ∼ 4.5 × 1012 mol/yr. The minor CO2 released into the atmosphere (2.5 ∼ 4.2 × 1011 mol/yr) is comparable to the carbon consumption driven by Himalayan weathering. This paper provides new insights into deep carbon cycling, notably that approximately 93% of deeply sourced carbon is trapped in the shallow crust, rendering orogenic processes carbon neutral and possibly acting as one of the major triggers of long‐term climate cooling in the Cenozoic.
Exosomes derived from mesenchymal stem cells in diabetes and diabetic complications
Authors: Jiao Yu-Rui , Chen Kai-Xuan , Tang Xiang , Tang Yu-Long , Yang Hai-Lin , Yin Yu-Long , Li Chang-Jun 
Published: April 2024

AbstractDiabetes, a group of metabolic disorders, constitutes an important global health problem. Diabetes and its complications place a heavy financial strain on both patients and the global healthcare establishment. The lack of effective treatments contributes to this pessimistic situation and negative outlook. Exosomes released from mesenchymal stromal cells (MSCs) have emerged as the most likely new breakthrough and advancement in treating of diabetes and diabetes‐associated complication due to its capacity of intercellular communication, modulating the local microenvironment, and regulating cellular processes. In the present review, we briefly outlined the properties of MSCs-derived exosomes, provided a thorough summary of their biological functions and potential uses in diabetes and its related complications.
The relationship between the network of non-coding RNAs-molecular targets and N6-methyladenosine modification in tumors of urinary system
Authors: Li Ruiming , Zhu Chunming , Wang Yuan , Wang Xia , Wang Yibing , Wang Jiahe , Wang Kefeng 
Published: April 2024

AbstractN6-methyladenosine (m6A) methylation, a prevalent eukaryotic post-transcriptional modification, is involved in multiple biological functions, including mediating variable splicing, RNA maturation, transcription, and nuclear export, and also is vital for regulating RNA translation, stability, and cytoplasmic degradation. For example, m6A methylation can regulate pre-miRNA expression by affecting both splicing and maturation. Non-coding RNA (ncRNA), which includes microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), does not encode proteins but has powerful impacts on transcription and translation. Conversely, ncRNAs may impact m6A methylation by affecting the expression of m6A regulators, including miRNAs targeting mRNA of m6A regulators, or lncRNAs, and circRNAs, acting as scaffolds to regulate transcription of m6A regulatory factors. Dysregulation of m6A methylation is common in urinary tumors, and the regulatory role of ncRNAs is also important for these malignancies. This article provides a systematic review of the role and mechanisms of action of m6A methylation and ncRNAs in urinary tumors.
Survival and rapid resuscitation permit limited productivity in desert microbial communities
Authors: Imminger Stefanie , Meier Dimitri V. , Schintlmeister Arno , Legin Anton , Schnecker Jörg , Richter Andreas , Gillor Osnat , Eichorst Stephanie A. , Woebken Dagmar 
Published: April 2024

AbstractMicrobial activity in drylands tends to be confined to rare and short periods of rain. Rapid growth should be key to the maintenance of ecosystem processes in such narrow activity windows, if desiccation and rehydration cause widespread cell death due to osmotic stress. Here, simulating rain with 2H2O followed by single-cell NanoSIMS, we show that biocrust microbial communities in the Negev Desert are characterized by limited productivity, with median replication times of 6 to 19 days and restricted number of days allowing growth. Genome-resolved metatranscriptomics reveals that nearly all microbial populations resuscitate within minutes after simulated rain, independent of taxonomy, and invest their activity into repair and energy generation. Together, our data reveal a community that makes optimal use of short activity phases by fast and universal resuscitation enabling the maintenance of key ecosystem functions. We conclude that desert biocrust communities are highly adapted to surviving rapid changes in soil moisture and solute concentrations, resulting in high persistence that balances limited productivity.
A cfDNA methylation-based tissue-of-origin classifier for cancers of unknown primary
Authors: Conway Alicia-Marie , Pearce Simon P. , Clipson Alexandra , Hill Steven M. , Chemi Francesca , Slane-Tan Dan , Ferdous Saba , Hossain A. S. Md Mukarram , Kamieniecka Katarzyna , White Daniel J. , Mitchell Claire , Kerr Alastair , Krebs Matthew G. , Brady Gerard , Dive Caroline , Cook Natalie , Rothwell Dominic G. 
Published: April 2024

AbstractCancers of Unknown Primary (CUP) remains a diagnostic and therapeutic challenge due to biological heterogeneity and poor responses to standard chemotherapy. Predicting tissue-of-origin (TOO) molecularly could help refine this diagnosis, with tissue acquisition barriers mitigated via liquid biopsies. However, TOO liquid biopsies are unexplored in CUP cohorts. Here we describe CUPiD, a machine learning classifier for accurate TOO predictions across 29 tumour classes using circulating cell-free DNA (cfDNA) methylation patterns. We tested CUPiD on 143 cfDNA samples from patients with 13 cancer types alongside 27 non-cancer controls, with overall sensitivity of 84.6% and TOO accuracy of 96.8%. In an additional cohort of 41 patients with CUP CUPiD predictions were made in 32/41 (78.0%) cases, with 88.5% of the predictions clinically consistent with a subsequent or suspected primary tumour diagnosis, when available (23/26 patients). Combining CUPiD with cfDNA mutation data demonstrated potential diagnosis re-classification and/or treatment change in this hard-to-treat cancer group.
Engineering a synthetic gene circuit for high-performance inducible expression in mammalian systems
Authors: De Carluccio Giuliano , Fusco Virginia , di Bernardo Diego 
Published: April 2024

AbstractInducible gene expression systems can be used to control the expression of a gene of interest by means of a small-molecule. One of the most common designs involves engineering a small-molecule responsive transcription factor (TF) and its cognate promoter, which often results in a compromise between minimal uninduced background expression (leakiness) and maximal induced expression. Here, we focus on an alternative strategy using quantitative synthetic biology to mitigate leakiness while maintaining high expression, without modifying neither the TF nor the promoter. Through mathematical modelling and experimental validations, we design the CASwitch, a mammalian synthetic gene circuit based on combining two well-known network motifs: the Coherent Feed-Forward Loop (CFFL) and the Mutual Inhibition (MI). The CASwitch combines the CRISPR-Cas endoribonuclease CasRx with the state-of-the-art Tet-On3G inducible gene system to achieve high performances. To demonstrate the potentialities of the CASwitch, we apply it to three different scenarios: enhancing a whole-cell biosensor, controlling expression of a toxic gene and inducible production of Adeno-Associated Virus (AAV) vectors.
Correlation-driven nonequilibrium exciton site transition in a WSe2/WS2 moiré supercell
Authors: Kim Jinjae , Park Jiwon , Choi Hyojin , Kim Taeho , Cha Soonyoung , Lee Yewon , Watanabe Kenji , Taniguchi Takashi , Kim Jonghwan , Jo Moon-Ho , Choi Hyunyong 
Published: April 2024

AbstractMoiré superlattices of transition metal dichalcogenides offer a unique platform to explore correlated exciton physics with optical spectroscopy. Whereas the spatially modulated potentials evoke that the exciton resonances are distinct depending on a site in a moiré supercell, there have been no clear demonstration how the moiré excitons trapped in different sites dynamically interact with the doped carriers; so far the exciton-electron dynamic interactions were presumed to be site-dependent. Thus, the transient emergence of nonequilibrium correlations are open questions, but existing studies are limited to steady-state optical measurements. Here we report experimental fingerprints of site-dependent exciton correlations under continuous-wave as well as ultrashort optical excitations. In near-zero angle-aligned WSe2/WS2 heterobilayers, we observe intriguing polarization switching and strongly enhanced Pauli blocking near the Mott insulating state, dictating the dominant correlation-driven effects. When the twist angle is near 60°, no such correlations are observed, suggesting the strong dependence of atomic registry in moiré supercell configuration. Our studies open the door to largely unexplored nonequilibrium correlations of excitons in moiré superlattices.
Stereoretentive enantioconvergent reactions
Authors: Bennett Steven H. , Bestwick Jacob S. , Demertzidou Vera P. , Jones David J. , Jones Helen E. , Richard François , Homer Joshua A. , Street-Jeakings Rosie , Tiberia Andrew F. , Lawrence Andrew L. 
Published: April 2024

AbstractEnantioconvergent reactions are pre-eminent in contemporary asymmetric synthesis as they convert both enantiomers of a racemic starting material into a single enantioenriched product, thus avoiding the maximum 50% yield associated with resolutions. All currently known enantioconvergent processes necessitate the loss or partial loss of the racemic substrate’s stereochemical information, thus limiting the potential substrate scope to molecules that contain labile stereogenic units. Here we present an alternative approach to enantioconvergent reactions that can proceed with full retention of the racemic substrate’s configuration. This uniquely stereo-economic approach is possible if the two enantiomers of a racemic starting material are joined together to form one enantiomer of a non-meso product. Experimental validation of this concept is presented using two distinct strategies: (1) a direct asymmetric coupling approach, and (2) a multicomponent approach, which exhibits statistical amplification of enantiopurity. Thus, the established dogma that enantioconvergent reactions require substrates that contain labile stereogenic units is shown to be incorrect.
CryoEM structures reveal how the bacterial flagellum rotates and switches direction
Authors: Singh Prashant K. , Sharma Pankaj , Afanzar Oshri , Goldfarb Margo H. , Maklashina Elena , Eisenbach Michael , Cecchini Gary , Iverson T. M. 
Published: April 2024

AbstractBacterial chemotaxis requires bidirectional flagellar rotation at different rates. Rotation is driven by a flagellar motor, which is a supercomplex containing multiple rings. Architectural uncertainty regarding the cytoplasmic C-ring, or ‘switch’, limits our understanding of how the motor transmits torque and direction to the flagellar rod. Here we report cryogenic electron microscopy structures for Salmonella enterica serovar typhimurium inner membrane MS-ring and C-ring in a counterclockwise pose (4.0 Å) and isolated C-ring in a clockwise pose alone (4.6 Å) and bound to a regulator (5.9 Å). Conformational differences between rotational poses include a 180° shift in FliF/FliG domains that rotates the outward-facing MotA/B binding site to inward facing. The regulator has specificity for the clockwise pose by bridging elements unique to this conformation. We used these structures to propose how the switch reverses rotation and transmits torque to the flagellum, which advances the understanding of bacterial chemotaxis and bidirectional motor rotation.