bluuebunny/crossref_metadata_2025_split huggingface dataset:
Major Clinical Adverse Events of Breast Implant in the Manufacturer and User Facility Device Experience Database
Authors: Su Bing , Chen Lichuan , Zhang Bohan , Wang Hong , Zhou Jie , Du Benjun 
Published: April 2024

Objective
Search the Manufacturer and User Facility Device Experience database to collect information on adverse events of breast implant. We analyzed the local complications and the breast implant illness (BII) of silicone breast implants, as well as saline breast implants separately, aim to provide a reference for women who want to breast augmentation.

Materials and Methods
The Manufacturer and User Facility Device Experience database was queried for events reports related to the breast implant between July 1, 2012, and June 30, 2022. Event year and reporting year were summarized. Patient problem was collected and analyzed to distinguish between local complications and BII.

Results
A total of 108,728 adverse events in the past 3 years were analyzed, silicone breast implants accounted for 62.1% and saline breast implants accounted for 37.9%. The most common local complication of women receiving silicone breast implants was “Capsular Contracture,” accounting for 48.73%. However, the incidence of “capsular contracture” in women who received saline breast implants was only 17.49%. The most common BII was “fatigue/weakness” in both women receiving 2 different breast implants, 17.20% in women receiving silicone breast implants and 24.71% in women receiving saline breast implants. Of note, in all the reports, there was a wide variation in the timing of reporting as compared with the timing of the adverse event.

Conclusions
Although the adverse events of breast implant cannot completely be determined from this study, we provide a reference for women who want to get breast implants, so that they can choose breast implants more carefully. In addition, a better understanding of BII may allow them to think further about whether the benefits of breast implants outweigh the risks.
HIV combined with skin infection of Nocardia brasiliensis: A rare case report
Authors: XING YUN , Li Shilu 
Published: April 2024

Introduction. The HIV virus can attack and gradually damage the human immune system, causing the host to be unprotected when infected. Nocardia is a type of opportunistic pathogenic bacteria that can easily cause infections in patients with chronic wasting diseases, immune dysfunction, and the use of immunosuppressants. Nocardia can invade various tissues and parts of the body, causing corresponding clinical symptoms. There are few reports of HIV patients being infected with Brazilian Nocardia.

Case presentation. This article reports a case of an HIV patient with concurrent infection with Brazilian Nocardia. A patient with HIV developed a lump on the surface of their left skin without any obvious cause. Due to improper disinfection and treatment methods, the condition worsened, and they subsequently sought medical attention at our hospital. A series of laboratory related tests are conducted clinically based on the patient's medical history, symptoms, and signs. Based on the test results, a reasonable treatment plan was adopted clinically, ultimately achieving satisfactory treatment outcomes for patients.

Conclusion . HIV patients are prone to various types of infections, even rare bacteria, as their immune function decreases. With the popularity of new identification methods such as mass spectrometry, laboratories should pay attention to traditional staining methods and use microscopes to detect pathogens.
Potent and reversible open-channel blocker of NMDA receptor derived from dizocilpine with enhanced membrane-to-channel inhibition
Authors: Misiachna Anna , Konecny Jan , Kolcheva Marharyta , Ladislav Marek , Prchal Lukas , Netolicky Jakub , Kortus Stepan , Barackova Petra , Langore Emily , Novak Martin , Hemelikova Katarina , Hermanova Zuzana , Hrochova Michaela , Pelikanova Anezka , Odvarkova Jitka , Pejchal Jaroslav , Kassa Jiri , Karasova Jana Zdarova , Korabecny Jan , Soukup Ondrej , Horak Martin 
Published: April 2024

AbstractN-methyl-D-aspartate receptors (NMDARs) play a significant role in developing several central nervous system (CNS) disorders. Currently, memantine, used for treating Alzheimer’s disease, and ketamine, known for its anesthetic and antidepressant properties, are two clinically used NMDAR open-channel blockers. However, despite extensive research into NMDAR modulators, many have shown either harmful side effects or inadequate effectiveness. For instance, dizocilpine (MK-801) is recognized for its powerful psychomimetic effects due to its high-affinity and nearly irreversible inhibition of the GluN1/GluN2 NMDAR subtypes. Unlike ketamine, memantine and MK-801 also act through a unique, low-affinity “membrane-to-channel inhibition” (MCI). We aimed to develop an open-channel blocker based on MK-801 with distinct inhibitory characteristics from memantine and MK-801. Our novel compound, K2060, demonstrated effective voltage-dependent inhibition in the micromolar range at key NMDAR subtypes, GluN1/GluN2A and GluN1/GluN2B, even in the presence of Mg2+. K2060 showed reversible inhibitory dynamics and a partially trapping open-channel blocking mechanism with a significantly stronger MCI than memantine. Using hippocampal slices, 30 µM K2060 inhibited excitatory postsynaptic currents in CA1 hippocampal neurons by ∼51%, outperforming 30 µM memantine (∼21% inhibition). K2060 exhibited No Observed Adverse Effect Level (NOAEL) of 15 mg/kg upon intraperitoneal administration in mice. Administering K2060 at a 10 mg/kg dosage resulted in brain concentrations of approximately 2 µM, with peak concentrations (Tmax) achieved within 15 minutes. Finally, applying K2060 with trimedoxime and atropine in mice exposed to tabun improved treatment outcomes. These results underscore K2060’s potential as a therapeutic agent for CNS disorders linked to NMDAR dysfunction.
NSm is a critical determinant for bunyavirus transmission between vertebrate and arthropod hosts
Authors: Terhzaz Selim , Kerrigan David , Almire Floriane , Szemiel Agnieszka M , Palmarini Massimo , Kohl Alain , Shi Xiaohong , Pondeville Emilie 
Published: April 2024

ABSTRACTBunyaviralesis a very large order including viruses infecting a variety of taxonomic groups such as arthropods, vertebrates, plants, and protozoan. Some bunyaviruses are transmitted between vertebrate hosts by blood-sucking arthropods and cause major diseases in humans and animals. It is not understood why only some bunyaviruses have evolved the capacity to be transmitted by arthropod vectors. Here we show that only vector-borne bunyaviruses express a non-structural protein, NSm, whose function has so far remained largely elusive. Using as experimental system Bunyamwera virus (BUNV) and its invertebrate host,Aedes aegypti, we show that NSm is dispensable for viral replication in mosquito cellsin vitrobut is absolutely required for successful infection in the female mosquito following a blood meal. More specifically, NSm is required for cell-to-cell spread and egress from the mosquito midgut, a known barrier to viral infection. Notably, the requirement for NSm is specific to the midgut; bypassing this barrier by experimental intrathoracic infection of the mosquito eliminates the necessity of NSm for virus spread in other tissues, including the salivary glands. Overall, we unveiled a key evolutionary process that allows the transmission of vector-borne bunyaviruses between arthropod and vertebrate hosts.
Leadership empowerment behavior and employee referrals: chain mediation of perceived challenge stress and employee experience
Authors: Li Teng , Yi Lingfeng 
Published: April 2024

Purpose
Internal employees of firms are a reliable source of information for potential job seekers. However, few studies have focused on why internal employees actively recommend their firms. Based on the social exchange theory, this study aims to construct a chain mediation model using perceived challenge stress and employee experience as mediators to explore how leadership empowerment behavior affects employee referrals.

Design/methodology/approach
Bootstrap repeated sampling analysis was conducted on a sample of 307 employees collected through two-time points.

Findings
Leadership empowerment behavior is positively related to employee referrals; perceived challenge stress and employee experience mediate the effect of leadership empowerment behavior on employee referrals, respectively; in addition, perceived challenge stress and employee experience play a chain mediating role between leadership empowerment behavior and employee referrals.

Originality/value
The findings can help provide insight into the drivers of employee referrals and can effectively guide organization reputation management.
The effectiveness of corporate diversity training from the trainers' perspective: results of a qualitative study in Germany
Authors: Rybnikova Irma , Weigel Annkathrin 
Published: April 2024

PurposeOrganizational diversity training is designed to enhance employees' skills and competencies regarding diversity and its management. The question of its effectiveness, and the conditions under which it thrives, remains a matter of debate. Unlike previous studies that have predominantly focused on the perspective of training participants, this study shifts the lens to the viewpoints of diversity training providers in Germany – a country where the formal requirement for diversity management was implemented relatively recently. The primary objective is to ascertain the critical factors influencing training effectiveness from the providers' perspective.Design/methodology/approachThis research draws upon case studies based on document analysis and qualitative interviews with diversity training providers across Germany.FindingsThe investigation reveals that the effectiveness of diversity training, as perceived by providers, hinges on several key factors: the organizational environment (including the widespread recognition of diversity issues and the presence of an organizational diversity framework), the attributes of diversity trainers (notably their personal familiarity with diversity) and the setting and design of the training (such as venue, duration and a blend of instructional approaches). A notable barrier to achieving effective training outcomes is the lack of supportive conditions within client companies, exemplified by limited training budgets, which impedes the accurate assessment of training effectiveness.Originality/valueThis study marks a novel contribution to the field by explicitly focusing on the perspective of diversity training providers in Germany. It provides new insights into the importance of the organizational context surrounding diversity education within the private sector.
Prediction of students’ performance in online learning using supervised machine learning
Authors: Khor Ean Teng , Darshan Dave 
Published: April 2024

PurposeThis study leverages social network analysis (SNA) to visualise the way students interacted with online resources and uses the data obtained from SNA as features for supervised machine learning algorithms to predict whether a student will successfully complete a course.Design/methodology/approachThe exploration and visualisation of the data were first carried out to gain a better understanding of the students, the course(s) each student was enrolled in and each course’s virtual learning resources. Following this, the construction of the social network graphs was performed to depict how each student behaved online before the degree centralities were computed for each of the nodes in a social network graph. Data pre-processing to assign labels based on the final result a student obtained in a course was then performed before we trained and tested models to predict which students did or did not graduate.FindingsThe study’s findings demonstrate that the constructed predictive model has good performance, as shown by the accuracy, precision, recall and f-measure metrics. The outcomes also showed that students’ use of online resources is a crucial element that influences how well they perform in their academics.Originality/valueThe similarity index is as low as 9%.
Navigating the challenges of AI-enabled circular economy in the food and beverage sector: strategies for sustainable transformation
Authors: Ajmera Deval , Kharub Manjeet , Krishna Aparna , Gupta Himanshu 
Published: April 2024

PurposeThe pressing issues of climate change and environmental degradation call for a reevaluation of how we approach economic activities. Both leaders and corporations are now shifting their focus, toward adopting practices and embracing the concept of circular economy (CE). Within this context, the Food and Beverage (F&B) sector, which significantly contributes to greenhouse gas (GHG) emissions, holds the potential for undergoing transformations. This study aims to explore the role that Artificial Intelligence (AI) can play in facilitating the adoption of CE principles, within the F&B sector.Design/methodology/approachThis research employs the Best Worst Method, a technique in multi-criteria decision-making. It focuses on identifying and ranking the challenges in implementing AI-driven CE in the F&B sector, with expert insights enhancing the ranking’s credibility and precision.FindingsThe study reveals and prioritizes barriers to AI-supported CE in the F&B sector and offers actionable insights. It also outlines strategies to overcome these barriers, providing a targeted roadmap for businesses seeking sustainable practices.Social implicationsThis research is socially significant as it supports the F&B industry’s shift to sustainable practices. It identifies key barriers and solutions, contributing to global climate change mitigation and sustainable development.Originality/valueThe research addresses a gap in literature at the intersection of AI and CE in the F&B sector. It introduces a system to rank challenges and strategies, offering distinct insights for academia and industry stakeholders.
Approaches to education for sustainability leadership development in higher education: an international comparative study in the Asia Pacific region
Authors: Ghasemy Majid , Elwood James A. , Scott Geoffrey 
Published: April 2024

Purpose
This study aims to focus on key approaches to education for sustainability (EfS) leadership development in the context of Malaysian and Japanese universities. The authors identify key indicators of effective EfS leadership development approaches using both descriptive and inferential analyses, identify and compare the preferred leadership learning methods of academics and examine the impact of marital status, country of residence and administrative position on the three EfS leadership development approaches.

Design/methodology/approach
The study is quantitative in approach and survey in design. Data were collected from 664 academics and analysed using the efficient partial least squares (PLSe2) methodology. To provide higher education researchers with more analytical insights, the authors re-estimated the models based on the maximum likelihood methodology and compared the results across the two methods.

Findings
The inferential results underscored the significance of four EfS leadership learning methods, namely, “Involvement in professional leadership groups or associations, including those concerned with EfS”, “Being involved in a formal mentoring/coaching program”, “Completing formal leadership programs provided by my institution” and “Participating in higher education leadership seminars”. Additionally, the authors noted a significant impact of country of residence on the three approaches to EfS leadership development. Furthermore, although marital status emerged as a predictor for self-managed learning and formal leadership development (with little practical relevance), administrative position did not exhibit any influence on the three approaches.

Practical implications
In addition to the theoretical and methodological implications drawn from the findings, the authors emphasize a number of practical implications, namely, exploring the applicability of the results to other East Asian countries, the adaptation of current higher education leadership development programmes focused on the key challenges faced by successful leaders in similar roles, and the consideration of a range of independent variables including marital status, administrative position and country of residence in the formulation of policies related to EfS leadership development.

Originality/value
This study represents an inaugural international comparative analysis that specifically examines EfS leadership learning methods. The investigation uses the research approach and conceptual framework used in the international Turnaround Leadership for Sustainability in Higher Education initiative and uses the PLSe2 methodology to inferentially pinpoint key learning methods and test the formulated hypotheses.
PR capacity on corporate boards: claiming the CSR and ESG responsibility?
Authors: Penning Timothy 
Published: April 2024

PurposeThe modern corporation is evaluated by many measures that go beyond profit, which was the emphasis for years previously. Today’s corporation is weighed against expectations of many stakeholders, including not just customers but employees, investors, the government and even the public at large with no discernible financial or other tie to a company. As such, corporate boards necessarily must be concerned with more than financial performance, including corporate social responsibility (CSR) and the increasing emphasis on environmental, social and governance (ESG) metrics. Given that public relations scholars and practitioners have long been concerned with stakeholder relationships, social responsibility and other non-financial indicators, it would make sense that public relations has a more obvious presence on corporate boards.Design/methodology/approachThis study examined the 25 companies in the Fortune Modern Board 25 to determine how many board members had a background or expertise in public relations that would contribute to the leadership necessary for the concerns of the modern corporation, and whether the boards had a committee designated to public relations or related functions.FindingsResults show that there are few corporate boards that have public relations represented prominently in either their members or committees. The same is true for executive leadership teams. Public relations or communications executives do appear to play some role in ESG, CSR and DEI reporting, but often there are staff members with those specific titles and roles.Research limitations/implicationsThe study was limited to 25 corporations on a Forbes list that ranked them as best in communicating ESG, CSR and DEI. The method examined publicly available literature which was revealing to the research questions, but more could be learned by interview or survey with CCOs.Practical implicationsThe study shows the current presence of public relations capacity in terms of members of corporate boards, corporate committees and among the C-suite is not significant. Also, rather than PR as a function owning modern concerns of DEI, ESG and CSR, there are professionals with specific expertise in those areas who are responsible for those corporate issues.Social implicationsCorporate social responsibility (CSR), ESG (environmental, social, governance) and DEI (diversity, equity and inclusion) have recently been stressed as important for corporations to measure and report. The role of the public relations profession in managing and/or communicating in these areas is important to consider in terms of public expectations and satisfaction of communication on these subjects.Originality/valueThis paper is unique in integrating public relations theory and practice with board theory and the current management concerns with ESG, CSR and DEI. Little if any previous research has considered which professions are in charge of communicating on these concerns.
Rural entrepreneurship and inequality: exploring trends in emerging economies through the lens of Lebanon
Authors: Baalbaki Chadi , El Khoury Aliaa 
Published: April 2024

Purpose
Limited research exists on the role of information access as a key success factor for rural entrepreneurs. The purpose of this study is to examine the importance of information access, among other inequality forms, in shaping entrepreneurial outcomes.

Design/methodology/approach
The authors used a qualitative, inductive research methodology. They conducted interviews with rural entrepreneurs and gained insights into the role of information access and basic tangible resources in shaping their ventures.

Findings
The authors identified two critical factors that impact rural entrepreneurs: inequalities in access to information and basic tangible resources. They found that inequalities in rural entrepreneurship are often interrelated, rather than isolated. The authors demonstrated that the relationship between entrepreneurship and inequality is not solely characterized by a positive or negative correlation but is a dynamic interplay where certain inequality forms may create barriers to opportunities for some individuals while creating opportunities for others.

Practical implications
The authors uncovered key barriers in rural entrepreneurship and constructed a roadmap to effectively address these challenges, providing valuable insights to policymakers and support initiatives and enabling the target of high-impact resources. This research supports efforts to provide rural entrepreneurs with equal opportunities to grow and succeed.

Originality/value
This research significantly contributes to the field by examining the complexities of entrepreneurship in emerging economies, with a particular focus on rural areas. The authors introduced a comprehensive conceptual model linking inequality and entrepreneurship, explored the challenges faced by rural entrepreneurs and offered strategic policy recommendations for development initiatives.
Implementation and sustainability of student peer-led physical activity programs in a school community
Authors: Lockyer Peggy , Le Fevre Deidre , Vickers Mark 
Published: April 2024

PurposeThis study sets out to investigate the elements of the collaborative culture required for the successful implementation and sustainability of programs in schools. It draws on a case study of a student peer-led physical activity (PA) program implemented within the complex and dynamic environment of school communities in New Zealand. The article outlines four key components needed to effectively implement and impact long term sustainability of a program within the school context.Design/methodology/approachThis qualitative case study examines the implementation of a new peer-led PA program introduced across eight New Zealand schools. Data were collected from semi-structured interviews with senior leaders, teachers and parents and analyzed through a complexity theory lens.FindingsEffective and sustainable program implementation requires a strategic, collaborative approach through actively engaging with and resourcing four key interacting components: student choice, voice and agency; collective responsibility; shared understanding of purpose; and curriculum coherence.Originality/valueThis research offers a pragmatic approach to developing collaborative school communities that can effectively implement change by highlighting key areas of focus that policymaker, school leaders and program designers can plan for.