bluuebunny/crossref_metadata_2025_split huggingface dataset:
Photosynthetic nano fibers: Living microalgae packaging into polyvinyl alcohol nanofibers using an electrospinning method
Authors: Haraguchi Ryota , Demura Mikihide , Kawakita Hidetaka , Oishi Yushi , Narita Takayuki 
Published: February 2024

AbstractAlthough microalgae are often studied for their biochemical extracts, utilizing them in a viable state opens new avenues for sustainable oxygenation in various systems. This study addresses the challenges of maintaining system homeostasis and presents an effective method for immobilizing live microalgae within poly(vinyl alcohol) (PVA) nanofibers using electrospinning technology. Characterization techniques, including scanning electron microscopy (SEM), fluorescence microscopy, Fourier‐transform infrared (FTIR) spectroscopy, and differential scanning calorimetry (DSC), were used to validate successful immobilization. Rheological studies were performed to investigate the influence of microalgae on the fiber morphology. Changing the PVA concentration, the fiber diameter could be regulated between 150 and 650 nm in the spinnable range. The addition of microalgae to the solution increased the viscosity of the prepared solution and reduced the resulting fiber diameter by approximately 2/3. Our results show that PVA nanofibers effectively encapsulate living microalgae and allow for sustained transport of nutrients and metabolites. The photosynthetic efficacy of the encapsulated microalgae was evaluated using dissolved oxygen measurements and showed two times higher rates of oxygen production and consumption compared with a film‐based approach. Our results show that PVA nanofibers effectively encapsulated living microalgae and allowed for the sustained transport of nutrients and metabolites. This innovative methodology provides a robust platform for immobilizing living microorganisms, with broad implications for applications ranging from regenerative medicine to sustainable agriculture.
Einfluss rezyklierter Gesteinskörnung auf das Verbundverhalten von Betonstahl in Beton
Authors: Wild Peter , Baudrexler Andreas , Kustermann Andrea , Stengel Thorsten 
Published: February 2024

AbstractDie Verwendung rezyklierter Gesteinskörnung in gängigen Hochbaubetonen wird als vielversprechender Ansatz betrachtet, um natürliche Ressourcen zu schonen. Die vorliegende Studie konzentriert sich darauf, das Verbundverhalten von Bewehrungsstahl in Betonen mit hohen Anteilen rezyklierter Gesteinskörnung aus Betonbruch zu untersuchen. Um einen möglichen Einfluss der Eigenschaften der Gesteinskörnung zu klären, wurden fünf unterschiedliche Körnungen in zwölf Betonen untersucht. Die Ergebnisse der Pull‐out‐Versuche wurden mithilfe eines analytischen Verbundgesetzes ausgewertet, um auf eine resultierende Bemessungsverbundspannung schließen zu können. Eine tendenzielle Abnahme der maximal aufnehmbaren Verbundspannung mit hohen Anteilen an rezyklierter Körnung konnte beobachtet werden. Die daraus resultierenden Bemessungswerte der Verbundfestigkeit liegen niedriger als beim Referenzbeton, jedoch über den Vorgaben des Eurocode 2. Die Abnahme der Bemessungsverbundspannung scheint sowohl über die Volumenanteile rezyklierter Körnung als auch über die Betonrohdichte abschätzbar. Insgesamt zeigt die Studie, dass das Verbundverhalten von Beton mit rezyklierter Gesteinskörnung dem des Normalbetons in Haft‐, Scher‐ und Reibungsverbund ähnelt, wobei die tatsächlichen Auswirkungen auch von den spezifischen Eigenschaften der verwendeten Körnung abhängen.
Women on corporate boards and firm financial performance: Empirical evidence from a multi‐country in Asia
Authors: Tran Thu Huong , Nguyen Thanh Si , Lien Mai Le Truc 
Published: February 2024

AbstractThe purpose of this research is to investigate the relationship between board gender diversity in management teams and financial performance of Asian firms in the transportation and logistics industry. To fulfill the research objectives, a total of 444 firm‐year observations operating in various nations of the Asia region from 2017 to 2020 were used in this present study, which was done by adopting the panel data regression approach. Results from a study demonstrate that the presence of female board members in the management structure will have a positive effect on financial performance of Asian firms in the sector of transportation and logistics at a certain level. Finally, our findings contribute to proposing some governance recommendations to enhance the presence and role of women in management positions in a firm's organizational structure in particular, while also promoting firm performance in the transportation and logistics industry in general.
Examining the impact of corporate social responsibility on customer delight, customer revisit intention and sustainable destination building: An empirical study of the hospitality industry
Authors: Bhat Dada Ab Rouf , Amar Shubam , Sharma Vivek 
Published: February 2024

AbstractThis research empirically investigates the impact of corporate social responsibility on customer delight and revisit intention of customers in the hospitality and tourism industry. Moreover, it investigates the impact of corporate social responsibility on the sustainable destination building. In order to achieve the set targets, data were sought through questionnaires from 282 guests visiting luxury hotels rendering services in Jammu and Kashmir and Delhi, India. To examine the link between the hypotheses, various normality tests, exploratory/confirmatory factor analysis and structural equation modeling were employed. The results show a strong correlation between all of the integrated model's elements and offer insightful managerial advice and implications for the hospitality sector.
Kurarinone targets JAK2‐STAT3 signaling in colon cancer‐stem‐like cells
Authors: Prajapati Kumari Sunita , Kumar Shashank 
Published: February 2024

AbstractNatural compounds are known to regulate stemness/self‐renewal properties in colon cancer cells at molecular level. In the present study, we first time studied the colon cancer stem‐like cells targeting potential of Kurarinone (KU) and explored the underlying mechanism. Cytotoxic potential of KU was checked in colon cancer cells. Colonosphere formation assay was performed to check the spheroid formation reduction potential of KU in HCT‐116 cells by using phase‐contrast microscopy. Stemness/self‐renewal marker expression was studied at mRNA and protein levels in colonosphere. The qRT‐PCR, western blot analysis, and flow cytometer techniques were used to assess the effect of KU treatment on cell cycle progression and apoptosis induction in colon cancer cells and colonosphere. Further, effect of KU treatment on pSTAT3 status and its nuclear translocation was also studied. KU treatment significantly decreased HCT‐116 cell proliferation and reduced sphere formation potential at IC30 (8.71 µM) and IC50 (20.34 µM) concentrations compared to respective vehicle‐treated groups, respectively. KU exposure significantly reduced the expression of CD44, c‐Myc, Bmi‐1, and Sox2 stemness/self‐renewal markers in colonosphere in a dose‐dependent manner. KU treatment inhibits JAK2‐STAT3 signaling pathway by reducing pSTAT3 levels and its nuclear translocation in HCT‐116 cells and colonosphere at IC50 concentration. KU treatment significantly decreased the expression of CCND1 and CDK4 cell cycle‐specific markers and arrested the HCT‐116 cells and colonosphere in G1‐phase. Further, KU treatment increased Bax/Bcl‐2 ratio, apoptotic cell population, cleaved caspase 3, and PARP‐1 in HCT‐116 cells and colonosphere. In conclusion, KU treatment decreases stemness/self‐renewal, induces cell cycle arrest and apoptosis in HCT‐116 colonosphere by down‐regulating CD44‐JAK2‐STAT3 axis. Thus, targeting stemness/self‐renewal and other cancer hallmark(s) by KU through CD44/JAK2/STAT3 signaling pathway might be a novel strategy to target colon cancer stem‐like cells.
Disseminated Aspergillus citrinoterreus and concurrent localized dermal phaeohyphomycosis in an immunosuppressed dog
Authors: Sender David , Hulsey Benjamin , Cañete‐Gibas Connie , Wiederhold Nathan , Lee Jung Keun , Finley Abigail , Cruz Catherine , White Mary E. 
Published: February 2024

Key Clinical messageWe report on a dog with immune‐mediated hemolytic anemia (IMHA) treated with immunomodulatory therapy that developed phaeohyphomycosis and Aspergillus citrinoterreus infections. This is the first reported case of A. citrinoterreus in dogs. It details cytological and microbiological findings leading to diagnosis and highlights the importance of investigating new lesions in immunocompromised patients.AbstractA 5‐year‐old Staffordshire terrier mix treated with immunosuppressive therapy for IMHA was diagnosed with concurrent disseminated A. citrinoterreus and localized Curvularia lunata infections. This case highlights the potential development of multiple concurrent opportunistic fungal infections and is the first reported case of A. citrinoterreus infection in a dog.
A rare case of thyrotoxic periodic paralysis revealing Graves' disease in a young Malian
Authors: Dembélé Mohamed Emile , Yalcouyé Abdoulaye , Cissoko Mamadou , Cissé Lassana , Guinto Cheick Oumar , Landouré Guida 
Published: February 2024

AbstractSporadic thyrotoxic periodic paralysis (TPP) is a rare muscle disorder that manifests with abrupt muscle weakness and hypokalemia associated with hyperthyroidism. It is mostly reported in the Asian population, and rare in Caucasians. Only few cases have been reported in people with black ancestry. Here, we report a rare case of thyrotoxic periodic paralysis revealing Graves' disease in a young Malian. A 17‐year‐old man was admitted in the Neurology clinic with rapid proximal tetraplegia that started after strenuous physical activities at the school. Clinical examination confirmed the proximal weakness. In addition, he had bilateral ptosis, exophthalmia, and horizontal ophthalmoplegia. Laboratory testing showed normal serum potassium and creatinine, low calcium and TSH levels. However, CK, FT4, thyroid stimulating hormone antibody, and acetylcholine receptor antibody levels were high. In addition, electrocardiogram was normal while thyroid Doppler‐ultrasound showed heterogeneous, hypoechogenic, hypertrophic, and hyper vascularized gland. Patient had completely recovered his limb weakness within the following hours with symptomatic treatment. The clinical findings were consistent with Graves' disease, and he was put on Neomercazole. He did not present another episode of paralysis after 4‐years of follow up. This is a first case of thyrotoxic periodic paralysis reported in Mali and one of the rare cases in sub‐Saharan Africa. Despite its scarcity, all patients with acute weakness consecutive to effort, whether recurring or not, should be screened for TPP.
An Organocatalytic Highly Enantioselective Stereospecific Synthesis of 1,1‐Disubstituted‐1,3‐Dihydroisobenzofurans
Authors: Kamilya Chandan , Gorad Sachin S. , Ghorai Prasanta 
Published: February 2024

AbstractHerein, we disclosed the asymmetric construction of an oxa‐quaternary stereocenter via an intramolecular oxa‐Michael (IOM) reaction in β‐substituted ortho‐hydroxymethyl chalcone by the formation of 1,1‐disubstituted‐1,3‐dihydroisobenzofuran using cinchona alkaloid‐based chiral amino‐squaramide catalyst. Both the (E‐ and Z)‐β‐substituted ortho‐hydroxymethyl chalcone provide (S)‐ and (R)‐enantiomers of the 1,1‐disubstituted‐1,3‐dihydroisobenzofuran with excellent stereospecificity. In general, excellent yields (up to 95 %) and enantioselectivity (up to 98 % ee) were obtained. Furthermore, the resulting 1,1‐disubstituted isobenzofuran or phthalan was converted to corresponding chiral 3,3‐disubstituted phthalides without losing the enantioselectivity. This methodology provides the core moiety of the (S)‐citalopram drug.
NiCo‐LDH coupled with 2D ZIF‐derived Co nitrogen doped carbon nanosheet arrays as a self‐supporting electrocatalyst for detection of formaldehyde
Authors: Ling Chengshuang , Xu Li , Ou Lian , Wu Jiaying , Tan Chao , Zhu Liping , Xiong Xiaoli 
Published: February 2024

AbstractFormaldehyde is susceptible to illegal addition to foodstuffs to extend their shelf life due to its antimicrobial, preservative and bleaching properties. In this study, a self‐supporting “nanosheet on nanosheet” arrays electrocatalyst with core‐shell heterostructure was prepared in situ by coupling NiCo layer double hydroxide with 2D ZIF derived Co‐nitrogen‐doped porous carbon on carbon cloth (Co−N/C@NiCo‐LDH NSAs/CC). Co−N/C nanosheet arrays act as a scaffold core with good electrical conductivity, providing more NiCo‐LDH nucleation sites to avoid NiCo‐LDH agglomeration, thus having fast mass/charge transfer performance. While the NiCo‐LDH nanosheet arrays shell with high specific surface area provide more active sites for electrochemical reactions. As an electrocatalytic sensing electrode, Co−N/C@NiCo‐LDH NSAs/CC has a wide linear range of 1 μM to 13 mM for formaldehyde detection, and the detection limit is 82 nM. Besides, the sensor has been applied to the detection of formaldehyde in food samples with satisfactory results.
An Efficient Probe for Bacterial Nitroreductase Imaging and Detection Based on NanoLuc‐Furimazine Bioluminescent Pair
Authors: Shi Ximeng , Wang Yumeng , Yu Jiaoyang , Yang Yating , Jin Zecheng , Wang Hanghang , Wu Dalei , Chen Wei , Guo Jianming , Zhang Yinan 
Published: February 2024

Comprehensive SummaryThe detection of critical endogenous species, such as bacteria in microenvironments in the body, requires better imaging tools for visualization and monitoring of biological events. Bioluminescence imaging is the most popular strategy for obtaining real‐time in living cells and organisms. Herein, we introduced a nitroaryl group on the C‐3 position and a hydroxy group at the C‐6 phenyl ring on furimazine to report the first bioluminescent probe (7) based on NanoLuc‐furimazine bioluminescent pair for the detection of nitroreductase in bacteria. The probe, which possessed up to 560‐fold intensity increase with a low detection limit of 16 ng/mL of nitroreductase, has the most efficient uncage efficiency in comparison with other bioluminescent congeners, thus enabling highly selective and sensitive visualization of NTR activity in a panel of clinical priority pathogens. Additionally, imaging of the recombinant strain as well as the NTR from mouse feces indicated the potential of this probe in the application of different mouse disease models.
Misalignment of social support in the social media posts of young adult cancer caregivers
Authors: Bybee Sara G. , Waters Austin R. , Smith Keely , Warner Echo L. 
Published: February 2024

AbstractBackgroundCompared with older cancer caregivers, young adult cancer caregivers (YACC) experience greater stress and depression during the first 6 months of caregiving. Social support can buffer the negative psychological effects associated with cancer caregiving. However, the misalignment of social support is associated with increased distress and worse emotional well‐being. As YACC are more likely to utilize social media (SM) to seek social support compared with older cancer caregivers, they may be at greater risk of experiencing the misalignment of social support and related negative outcomes.ObjectiveThe purpose of this study was to identify ways that SM posts containing support for YACC's were potentially misaligned with the social support desired by YACC.MethodsIn this secondary analysis, cancer‐related SM posts (N = 760) from 34 YACC's SM accounts were extracted for 6 months following the day of cancer diagnosis and imported into NVivo qualitative analysis software. Open coding of posts from four YACC identified a pattern of SM posts containing responses that may misalign with social support requests, and could be perceived as dismissive of YACC's emotions. Similar posts were grouped together, forming categories which were used to create a codebook and applied in coding all posts from the remaining 30 YACC.ResultsContent analysis identified three categories of social support misalignment originating from YACC's SM posts: supplications (n = 251, 33%), prevailing (n = 7, 10.1%), and consolations (n = 16, 2.1%). Supplications involved prayer or trust in god, prevailing posts compared dealing with cancer to a fight and suggested that the person would overcome cancer, and consolations used quotes, song lyrics, and or general reassurances in SM posts.ConclusionsFindings suggest that when YACC use SM during cancer experiences, they may interpret SM posts as social support or as misalignment of social support requests, which in turn can lead to either improved quality of life or additional distress (respectively). This study adds to the body of knowledge regarding how YACC use social media for social support and may inform future interventions designed to match YACC's desired support with support offered.
A Liouville‐type theorem for cylindrical cones
Authors: Edelen Nick , Székelyhidi Gábor 
Published: February 2024

AbstractSuppose that is a smooth strictly minimizing and strictly stable minimal hypercone (such as the Simons cone), , and a complete embedded minimal hypersurface of lying to one side of . If the density at infinity of is less than twice the density of , then we show that , where is the Hardt–Simon foliation of . This extends a result of L. Simon, where an additional smallness assumption is required for the normal vector of .
CRISPR‐based gene therapy for wet age‐related macular degeneration in mouse model
Authors: Xie Dongchun , Chen Yuxi , Hu Sihui , Huang Li , Huang Junjiu 
Published: February 2024

AbstractWet age‐related macular degeneration (AMD) is a common cause of vision loss in the elderly. It is characterised by choroidal neovascularisation (CNV), caused by overexpression of vascular endothelial growth factor (VEGF), resulting in abnormal vessel proliferation. Current clinical management predominantly relies on anti‐VEGF agents, which require frequent and costly injections. Clustered regularly interspaced short palindromic repeats (CRISPR) technology has emerged as a promising strategy for permanently suppressing angiogenesis by targeting the VEGF‐related pathway. Increased research suggests that disrupting this pathway holds potential for preventing CNV progression. This review provides an overview of the aetiology, classification and pathophysiology of wet AMD, followed by a concise summary of current gene editing research using the CRISPR/Cas system via viral vector delivery strategies to target ocular pro‐angiogenic factors, including Hif‐1α, VEGF and VEGFR. The importance of timely targeting of VEGFA is emphasised and the challenges associated with gene editing therapies are also highlighted.
Targeting KDM4 family epigenetically triggers antitumour immunity via enhancing tumour‐intrinsic innate sensing and immunogenicity
Authors: Sun Mayu , Han Xiaoyu , Li Jinyang , Zheng Jiali , Li Jingquan , Wang Hui , Li Xiaoguang 
Published: February 2024

AbstractDespite the remarkable clinical efficacy of cancer immunotherapy, considerable patients fail to benefit from it due to primary or acquired resistance. Tumours frequently hijack diverse epigenetic mechanisms to evade immune detection, thereby highlighting the potential for pharmacologically targeting epigenetic regulators to restore the impaired immunosurveillance and re‐sensitise tumours to immunotherapy. Herein, we demonstrated that KDM4‐targeting chemotherapeutic drug JIB‐04, epigenetically triggered the tumour‐intrinsic innate immune responses and immunogenic cell death (ICD), resulting in impressive antitumour effects. Specifically, JIB‐04 induced H3K9 hypermethylation through specific inhibition of the KDM4 family (KDM4A–D), leading to impaired DNA repair signalling and subsequent DNA damage. As a result, JIB‐04 not only activated the tumour‐intrinsic cyclic GMP‐AMP synthase (cGAS)‐STING pathway via DNA‐damage‐induced cytosolic DNA accumulation, but also promoted ICD, releasing numerous damage‐associated molecular patterns. Furthermore, JIB‐04 induced adaptive resistance through the upregulation of programmed death‐ligand 1 (PD‐L1), which could be overcome with additional PD‐L1 blockade. In human tumours, KDM4B expression was negatively correlated with clinical outcomes, type I interferon signatures, and responses to immunotherapy. In conclusion, our results demonstrate that targeting KDM4 family can activate tumour‐intrinsic innate sensing and immunogenicity, and synergise with immunotherapy to improve antitumour outcomes.
Association of CSF biomarkers with MRI brain changes in Alzheimer's disease
Authors: Seidu Nazib M , Kern Silke , Sacuiu Simona , Sterner Therese Rydberg , Blennow Kaj , Zetterberg Henrik , Lindberg Olof , Ferreira Daniel , Westman Eric , Zettergren Anna , Skoog Ingmar 
Published: February 2024

AbstractThe relation between cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) and magnetic resonance imaging (MRI) measures is poorly understood in cognitively healthy individuals from the general population. Participants’ (n = 226) mean age was 70.9 years (SD = 0.4). CSF concentrations of amyloid beta (Aβ)1‐42, total tau (t‐tau), phosphorylated tau (p‐tau), neurogranin, and neurofilament light, and volumes of hippocampus, amygdala, total basal forebrain (TBF), and cortical thickness were measured. Linear associations between CSF biomarkers and MRI measures were investigated. In Aβ1‐42 positives, higher t‐tau and p‐tau were associated with smaller hippocampus (P = 0.001 and P = 0.003) and amygdala (P = 0.005 and P = 0.01). In Aβ1‐42 negatives, higher t‐tau, p‐tau, and neurogranin were associated with larger TBF volume (P = 0.001, P = 0.001, and P = 0.01). No associations were observed between the CSF biomarkers and an AD signature score of cortical thickness. AD‐specific biomarkers in cognitively healthy 70‐year‐olds may be related to TBF, hippocampus, and amygdala. Lack of association with cortical thickness might be due to early stage of disease.
Clinical classification of memory and cognitive impairment with multimodal digital biomarkers
Authors: Banks Russell , Higgins Connor , Greene Barry R. , Jannati Ali , Gomes‐Osman Joyce , Tobyne Sean , Bates David , Pascual‐Leone Alvaro 
Published: February 2024

AbstractINTRODUCTIONEarly detection of Alzheimer's disease and cognitive impairment is critical to improving the healthcare trajectories of aging adults, enabling early intervention and potential prevention of decline.METHODSTo evaluate multi‐modal feature sets for assessing memory and cognitive impairment, feature selection and subsequent logistic regressions were used to identify the most salient features in classifying Rey Auditory Verbal Learning Test‐determined memory impairment.RESULTSMultimodal models incorporating graphomotor, memory, and speech and voice features provided the stronger classification performance (area under the curve = 0.83; sensitivity = 0.81, specificity = 0.80). Multimodal models were superior to all other single modality and demographics models.DISCUSSIONThe current research contributes to the prevailing multimodal profile of those with cognitive impairment, suggesting that it is associated with slower speech with a particular effect on the duration, frequency, and percentage of pauses compared to normal healthy speech.