bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Binding Mode of Petrosaspongiolide M to the Human Group IIA Phospholipase A2: Exploring the Role of Covalent and Noncovalent Interactions in the Inhibition Process
Authors: Monti Maria Chiara , Casapullo Agostino , Cavasotto Claudio N. , Tosco Alessandra , Dal Piaz Fabrizio , Ziemys Arturas , Margarucci Luigi , Riccio Raffaele 
Published: December 2008

AbstractWe report an analysis of the mechanism of human group IIA secretory phospholipase A2(sPLA2‐IIA) inhibition by the natural anti‐inflammatory sesterterpene petrosaspongiolide M (PM). The amphiphilic PM, a γ‐hydroxybutenolide marine terpenoid, selectively reacts with the sPLA2‐IIA Lys67 residue, located near the enzyme–membrane interfacial binding surface, and covalently modifies the enzyme through imine formation. Furthermore, PM is able to target the active site of sPLA2‐IIA through several van der Waals/electrostatic complementarities. The two events cannot co‐occur on a single PLA2molecule, so they may contribute separately to enzyme inhibiton. A more intriguing hypothesis suggests a double interaction of PM with two enzyme molecules, one of them covalently modified and the other contacting the inhibitor through its active site. We have explored the occurrence of this unusual binding mode leading to PM‐induced PLA2supramolecular complexes. These insights could suggest new PLA2‐inhibition‐based therapeutic strategies.
Luminescent Bimetallic Lanthanide Bioprobes for Cellular Imaging with Excitation in the Visible‐Light Range
Authors: Deiters Emmanuel , Song Bo , Chauvin Anne‐Sophie , Vandevyver Caroline D. B. , Gumy Frédéric , Bünzli Jean‐Claude G. 
Published: December 2008

AbstractA series of homoditopic ligands H2LCX(X=4–6) has been designed to self‐assemble with lanthanide ions (LnIII), resulting in neutral bimetallic helicates of overall composition [Ln2(LCX)3] with the aim of testing the influence of substituents on the photophysical properties, particularly the excitation wavelength. The complex species are thermodynamically stable in water (log β23in the range 26–28 at pH 7.4) and display a metal‐ion environment with pseudo‐D3symmetry and devoid of coordinated water molecules. The emission of EuIII, TbIII, and YbIIIis sensitised to various extents, depending on the properties of the ligand donor levels. The best helicate is [Eu2(LC5)3] with excitation maxima at 350 and 365 nm and a quantum yield of 9 %. The viability of cervix cancer HeLa cells is unaffected when incubated with up to 500 μm of the chelate during 24 h. The helicate permeates into the cells by endocytosis and locates into lysosomes, which co‐localise with the endoplasmatic reticulum, as demonstrated by counterstaining experiments. The relatively long excitation wavelength allows easy recording of bright luminescent images on a confocal microscope (λexc=405 nm). The new lanthanide bioprobe remains undissociated in the cell medium, and is amenable to facile derivatisation. Examination of data for seven EuIIIand TbIIIbimetallic helicates point to shortcomings in the phenomenological rules of thumb between the energy gap ΔE(3ππ*–5DJ) and the sensitisation efficiency of the ligands.
Wie akustische Kaltgasfallen wirken. “Tannenbäume” im stehenden Ultraschallfeld
Authors: Tuckermann Rudolf , Bauerecker Sigurd 
Published: December 2008

AbstractDer Kaltgasfalleneffekt ermöglicht den Einfang von kalten (bzw. schweren) Gasen und Aerosolen in starken, stehenden Ultraschallfeldern. Der Effekt kann mit klassischen akustischen Prinzipien verstanden werden. Man kann ihn kontrolliert nutzen, um Temperaturen bis zu –100 °C in den Bereichen der Druckknoten eines stehenden Ultraschallfeldes (und somit in der unmittelbaren Umgebung einer levitierten Probe) zu erzeugen. Diese Kaltgas‐ und Aerosolfallen werden hier mit einem besonders leistungsstarken Levitator generiert. In ihnen lassen sich beispielsweise die Bildung und das Wachstum von Eis‐ und Schneepartikeln aus primärem Eisaerosol untersuchen, ebenso wie Gefrier‐ und Schmelzprozesse an einzelnen berührungsfrei levitierten Wassertropfen. Mit Hilfe von Hochgeschwindigkeitskameras (VIS, IR) lässt sich die schnelle erste Stufe der Eisbildung an schwebenden unterkühlten Tropfen erforschen.
Mit Antikörpern Alzheimer auf der Spur
Authors: Feil Sylvia 
Published: December 2008

AbstractIm Gehirn von Alzheimer‐Patienten entstehen zwischen den Zellen amyloide Plaques, die aus schwer abbaubaren Fibrillen bestehen. Am Jenaer Fritz‐Lipmann‐Institut (FLI) betreute Marcus Fändrich, jetzt am Max‐Planck‐Institut in Halle, die Suche nach einem Antikörper, der die Konformation zwischen Fibrille und Fibrillenvorstufe unterscheiden kann. Gefunden hat er ihn in Zusammenarbeit mit dem Hans‐Knöll‐Institut in Jena in einer Bibliothek, deren Antikörper ursprünglich aus der Familie der Kamele stammen.
Viren
Authors: Hille‐Rehfeld Annette 
Published: December 2008

AbstractDen Nobelpreis für Physiologie oder Medizin teilt sich im Jahr 2008 Harald zur Hausen (Heidelberg) für den Nachweis, dass Viren Krebs auslösen können, mit Francoise Barré‐Sinoussi und Luc Montagnier (Paris) für die Isolierung des HIV (Human immunodeficiency virus).
Keramikmuseum Westerwald und Porzellanmuseum Schloss Fürstenberg
Authors: Schwedt Georg 
Published: December 2008

AbstractAn den Standorten historischer Manufakturen – in Höhr‐Grenzhausen bzw. Fürstenberg an der Weser – zeigen Museen die Entwicklung der Keramik‐ und Porzellanherstellung, sowohl mit chemisch‐technologischen, wirtschaftlichen als auch kulturgeschichtlichen Aspekten.
Semi‐Synthetic Ecdysteroids as Gene‐Switch Actuators: Synthesis, Structure–Activity Relationships, and Prospective ADME Properties
Authors: Lapenna Silvia , Dinan Laurence , Friz Jennifer , Hopfinger Anton J. , Liu Jianzhong , Hormann Robert E. 
Published: December 2008

AbstractThe ligand‐inducible, ecdysteroid receptor (EcR) gene‐expression system can add critical control features to protein expression in cell and gene therapy. However, potent natural ecdysteroids possess absorption, distribution, metabolism and excretion (ADME) properties that have not been optimised for use as gene‐switch actuators in vivo. Herein we report the first systematic synthetic exploration of ecdysteroids toward modulation of gene‐switch potency. Twenty‐three semi‐synthetic O‐alkyl ecdysteroids were assayed in both a natural insect system (Drosophila BII cells) and engineered gene‐switch systems in mammalian cells using Drosophila melanogaster, Choristoneura fumiferana, and Aedes aegypti EcRs. Gene‐switch potency is maintained, or even enhanced, for ecdysteroids methylated at the 22‐position in favourable cases. Furthermore, trends toward lower solubility, higher permeability, and higher blood–brain barrier penetration are supported by predicted ADME properties, calculated using the membrane‐interaction (MI)‐QSAR methodology. The structure–activity relationship (SAR) of alkylated ecdysteroids indicates that 22‐OH is an H‐bond acceptor, 25‐OH is most likely an H‐bond donor, and 2‐OH and 3‐OH are donors and/or acceptors in network with each other, and with the EcR. The strategy of alkylation points the way to improved ecdysteroidal actuators for switch‐activated gene therapy.
Neuron and glia numbers in the basolateral nucleus of the amygdala from preweaning through old age in male and female rats: A stereological study
Authors: Rubinow Marisa J. , Juraska Janice M. 
Published: December 2008

AbstractThe rat basolateral nucleus of the amygdala continues to develop connectivity with the frontal cortex through the periadolescent period and even into young adulthood. Although neuronal loss in the prefrontal cortex has been found during the periadolescent period, prior literature has not examined whether neuron number in the basolateral amygdala is stable through this period. In addition, aging of the rat basolateral nucleus is accompanied by significant increases in the dendritic tree of its principal neurons, but whether this occurs in the context of neuronal death has not been previously explored. In the present study, a stereological examination of neuron and glia numbers in the rat basolateral amygdalar nucleus was undertaken in male and female hooded rats at four ages across the lifespan. Our findings indicate 1) a significant decrease in the number of neurons and glia in the basolateral nucleus between adolescence and adulthood; and 2) the number of glia, as well as the volume of the basolateral nucleus, increases between adulthood and old age, whereas neuron number remains stable. These findings provide an important cellular context for interpretation of the neurochemical and other alterations documented in developmental and age‐related literature on the rat basolateral amygdala, and underline the substantial development of this brain area during adolescence, as well as its comparative preservation during aging. J. Comp. Neurol. 512:717–725, 2009. © 2008 Wiley‐Liss, Inc.
Morphological heterogeneity of layer VI neurons in mouse barrel cortex
Authors: Chen Chia‐Chien , Abrams Svetlana , Pinhas Alex , Brumberg Joshua C. 
Published: December 2008

AbstractUnderstanding the basic neuronal building blocks of the neocortex is a necessary first step toward comprehending the composition of cortical circuits. Neocortical layer VI is the most morphologically diverse layer and plays a pivotal role in gating information to the cortex via its feedback connection to the thalamus and other ipsilateral and callosal corticocortical connections. The heterogeneity of function within this layer is presumably linked to its varied morphological composition. However, so far, very few studies have attempted to define cell classes in this layer using unbiased quantitative methodologies. Utilizing the Golgi staining technique along with the Neurolucida software, we recontructed 222 cortical neurons from layer VI of mouse barrel cortex. Morphological analyses were performed by quantifying somatic and dendritic parameters, and, by using principal component and cluster analyses, we quantitatively categorized neurons into six distinct morphological groups. Additional systematic replication on a separate population of neurons yielded similar results, demonstrating the consistency and reliability of our categorization methodology. Subsequent post hoc analyses of dendritic parameters supported our neuronal classification scheme. Characterizing neuronal elements with unbiased quantitative techniques provides a framework for better understanding structure–function relationships within neocortical circuits in general. J. Comp. Neurol. 512:726–746, 2009. © 2008 Wiley‐Liss, Inc.
Robust gender and age estimation under varying facial pose
Authors: Takimoto Hironori , Mitsukura Yasue , Fukumi Minoru , Akamatsu Norio 
Published: December 2008

AbstractThis paper presents a method for gender and age estimation which is robust to changing facial pose. We propose a feature point detection method, called the adapted retinal sampling method (ARSM), and a feature extraction method. A basic concept of the ARSM is to add knowledge about the facial structure to the retinal sampling method. In this method, feature points are detected on the basis of seven points corresponding to facial organs from a facial image. The reason why we used seven points as the basis of feature point detection is that facial organs are conspicuous in the facial region, and are comparatively easy to extract. As features robust to changing facial pose, skin texture, hue, and the Gabor jet are used for gender and age estimation. For classification of gender and estimation of age, we use a multilayered neural network. We also examine the left– right symmetry of faces in connection with gender and age estimation by the proposed method. © 2008 Wiley Periodicals, Inc. Electron Comm Jpn, 91(7): 32– 40, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/ecj.10125
Fingerprint sensor based on interior optical characteristics of the finger
Authors: Sano Emiko , Maeda Takuji , Matsushita Masahito , Shikai Masahiro , Sasakawa Koichi , Ohmi Masato , Haruna Masamitsu 
Published: December 2008

AbstractFingerprints are widely used as a method of personal authentication because they have the best balance among authentication performance, cost, device size, and ease of use. However, conventional fingerprint sensors have problems: the quality of the fingerprint pattern is sometimes not good due to the condition of the finger surface, such as moisture or wrinkles. These problems are caused by the operating principle of the sensors. Most fingerprint sensors detect a fingerprint pattern from the presence or absence of convexities and concavities of the finger surface. To solve these problems, we have devised a new kind of fingerprint sensor, which detects a fingerprint pattern by the use of optical characteristics inside the finger. This method is based on the new scientific discovery that a layer of skin inside the finger has a transmittance distribution corresponding to the pattern of the concavities and convexities of the finger surface. Therefore, this method can detect stable fingerprint images at all times regardless of the finger surface conditions (moisture, wrinkles). In this paper, we describe the principle of a new type of fingerprint sensor and demonstrate the effectiveness of the proposed sensor by examples. © 2008 Wiley Periodicals, Inc. Electron Comm Jpn, 91(7): 48–56, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/ecj.10127
New control for HVDC system connected to large windfarm
Authors: Tanomura Kenichi , Arai Junichi , Noro Yasuhiro , Takagi Kikuo , Kato Masakazu 
Published: December 2008

AbstractHVDC consisting of self‐commutated inverters is able to be applied for power transmission connecting from a remote large windfarm to a weak AC system. Most self‐commutated HVDC is applied for connection between two AC systems that have synchronous power sources, but it is not suitable for a windfarm that consists of induction generators without synchronous power source. This paper presents new control for the self‐commutated HVDC system connected to a large windfarm of induction generators. The effect of the proposed control is shown by EMTP simulation. ©2008 Wiley Periodicals, Inc. Electr Eng Jpn, 166(4): 31–39, 2009; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/eej.20539
Synthesis and Characterization of Thiolate‐Oxo Ligated Zinc Alkyl Derivatives for Production of Zn‐Based Nanoparticles
Authors: Boyle Timothy J. , Pratt Harry D. , Alam Todd M. , Headley Thomas , Rodriguez Mark A. 
Published: December 2008

AbstractA series of mercapto‐oxo containing reagents [3‐mercaptopropionic acid (H2‐3MPA), 4‐mercaptophenol (H2‐4MP), 2‐mercaptopyridine N‐oxide (H‐2MPO)] was treated with diethylzinc (ZnEt2) in hexanes/pyridine (py) to yield {(μ4‐3MPA)[Zn(Et)(py)]4}∞ (1), [(py)2(Et)Zn(μ3‐4MP)Zn(Et)(py)]2 (2), and (2MPO)Zn(Et)py (3). For polymeric 1, each of the functional sites of the 3MPA was bound to four tetrahedral (Td) coordinated Zn(Et)(py) subunits. The sulfur of the 3MPA bridges two of the Zn(Et)(py) subunits, which are also bridged by the two carboxylate oxygens of another 3MPA to propagate the chain. In contrast, 2 forms a discrete tetranuclear species consisting of two Zn(Et)(py) moieties bridged by the oxygens of two 4MP ligands with the thiolate sites of each terminated by Zn(Et)(py)2 moieties. Compound 3 adopts a monomeric species using a chelating 2MPO, a terminal Et, and a bound py to fill the Td coordination of the Zn metal center. Compounds 1–3 were then used to generate nanoparticles via solution precipitation and solvothermal routes to determine the effect these precursors have on the morphology and composition of the final materials produced. Compounds 1–3 were found to form zincite, zinc metal, or mixed zincite/wurtzite phases from solution precipitation or solvothermal routes; however, no routes yielded the mixed anion (i.e., ZnOxSy) materials. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Binuclear Copper(II) Chelates with Heptadentate Ligands: Synthesis, Structure, Magnetic Properties, DFT Studies, and Catecholase and Hydrolytic DNA Cleavage Activity
Authors: Banerjee Atanu , Singh Reena , Colacio Enrique , Rajak Kajal Krishna 
Published: December 2008

AbstractTwo binucleating heptadentate ligands 2,6‐bis[{[(2‐hydroxybenzyl)(N,N‐(dimethylamino)ethyl]amino}methyl]‐4‐methylphenol (H3L1) and 2,6‐bis[{(2‐hydroxybenzyl)(N‐(2‐pyridylmethyl)amino}methyl]‐4‐methylphenol (H3L2) were used to synthesize the two new copper(II) complexes [Cu2(L1)(N3)]·2H2O (1·2H2O) and [Cu2(HL2)(O2CPh)(H2O)]PhCO2·H2O (2·H2O). X‐ray diffraction studies disclose that 1 is made up from bridging phenoxido and azido group in an equatorial fashion, whereas 2 is bridged axially–equatorially through a central cresolato and syn–syn benzoate moiety. The geometry around the copper(II) centers is distorted square pyramid in both cases. Variable‐temperature magnetic susceptibility data reveals that 1 is moderately antiferromagnetically coupled (J = –119 cm–1) and 2 is very weakly antiferromagnetic (J = –1.0 cm–1). The structural features, as well as the presence of orbital countercomplementary effects, are associated with the magnetic behavior. Theoretical calculations with the use of broken symmetry density functional theory also establish the experimental values of the exchange coupling constants (J). In our case, only 2 exhibits catalytic activity in the oxidation of 3,5‐di‐tert‐butylcatechol (3,5‐DTBC) at pH 9.5 and hydrolytic cleavage of plasmid DNA in the absence of any added cofactor, whereas complex 1 cannot display catecholase activity or DNA interaction as a result of strong CuII–azido binding.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
The Reactions of Silver, Zirconium, and Hafnium Fluorides with Liquid Ammonia: Syntheses and Crystal Structures of Ag(NH3)2F·2NH3, [M(NH3)4F4]·NH3 (M = Zr, Hf), and (N2H7)F
Authors: Kraus Florian , Baer Sebastian A. , Fichtl Matthias B. 
Published: December 2008

AbstractBy reaction of the tetrafluorides MF4 or the ternary silver fluorides Ag3M2F14 (M = Zr, Hf) with dry liquid ammonia at –40 °C, the pentaammoniates [M(NH3)4F4]·NH3 (1, M = Zr; 2, M = Hf) were obtained, and these compounds represent hitherto unknown molecular inorganic Zr and Hf compounds that simultaneously bear nitrogen and fluorine ligands. The compounds crystallize isotypically in the shape of colorless needles in the tetragonal space group P4/ncc. As a further product [NH4(NH3)]F (3) was isolated in the form of colorless cubes in the orthorhombic space group Pca21. It is the first ammoniate of ammonium fluoride. Ag(NH3)2F·2NH3 (4) can be synthesized either from AgF or AgF2 in liquid ammonia. The compound crystallizes merohedrally twinned in the orthorhombic space group Pnna and represents the first crystallographically characterized diamine silver(I) halide complex. In the latter two structures, free fluoride anions are encountered. The ammoniates are highly temperature‐sensitive and decompose at temperatures above –30 °C due to their ammonia pressure.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Spin‐Crossover 2D Metal–Organic Frameworks with a Redox‐Active Ligand: [Fe(ttf‐adpy)2M(CN)4]·nH2O (ttf‐adpy = 4‐Tetrathiafulvalenylcarboxamidopyridine; MII = Ni, Pd, Pt)
Authors: Martínez Víctor , Gaspar Ana Belén , Muñoz M. Carmen , Ballesteros Rafael , Ortega‐Villar Norma , Ugalde‐Saldívar Víctor M. , Moreno‐Esparza Rafael , Real José Antonio 
Published: December 2008

AbstractA new ttf (tetrathiofulvalene) ligand containing an amidopyridine moiety was synthesized and characterized. The electrochemical study of the 4‐tetrathiofulvalenylcarboxamidopyridine (ttf–adpy) ligand showed two reversible oxidation processes at EI′1/2 = 0.08 V/Fc+–Fc and EII′1/2 = 0.26 V/Fc+–Fc. The crystal structure of [(ttf–adpyH)2Pt(CN)4] (1) was solved at 293 K, where 1 displays the triclinic space group P$\bar {1}$. The ttf–adpyH+ molecule is planar, and the bond lengths within the ttf core are in the usual range for neutral ttf moieties. The ttf–adpyH+ molecules and the [Pt(CN)4]2– anions organize in a three‐dimensional network by means of hydrogen bonds and short S···S contacts. In the network, the ttf–adpy molecules order following the pattern ‐D‐A‐D‐A‐ (D = donor, pyridine; A = acceptor, ttf moieties). Reaction of the Fe(BF4)2·6H2O salt, ttf–adpy ligand and the [M(CN)4]2– coordinating counterions led to the 2D Hofmann‐like polymers {Fe(ttf–adpy)2[M(CN)4]}·nH2O [M = NiII; n = 1.5 (2), 0 (5); PdII; n = 2 (3), 0 (6); PtII n = 2 (4), 0 (7)]. A 2D structure for 2–7 was proposed on the basis of analytical data. Compounds 2–4 present a complete thermally induced two‐step spin transition. It is observed in the temperature interval from 100 to 200 K for 2; whereas for 3 and 4 it occurred in the interval of 200–250 K. The spin‐transition properties of 2–4 were found to be strongly dependent on the water content, as nonhydrated materials 5–7 are paramagnetic in the studied temperature range (5–350 K). The thermodynamic parameters associated with the spin transition estimated from DSCmeasurements are: ΔH1 = 5.7 kJ mol–1 (3), 6.2 kJ mol–1 (4),ΔH2 = 6.5 kJ mol–1 (3), 7.2 kJ mol–1 (4) and ΔS1 = 24 J K–1 mol–1 (3), 26.6 J K–1 mol–1 (4), ΔS2 = 30.4 J K–1 mol–1 (3) and32.8 J K–1 mol–1(4).(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Hybrid Assembly of Layered Double Hydroxide Nanocrystals with Inorganic, Polymeric and Biomaterials from Micro‐ to Nanometer Scales (Eur. J. Inorg. Chem. 36/2008)
Authors: Lee Jong Hyeon , Nam Hye Jin , Rhee Seog Woo , Jung Duk‐Young 
Published: December 2008

AbstractThe cover picture shows a wide range of hybrid assemblies; caged proteins (nanometer), polymer beads (hundreds nm) and zeolite crystals (micrometer scale) are self‐assembled onto highly ordered monolayers of layered double hydroxide (LDH) nanocrystals by the electrostatic attraction between the negatively charged particles and the positively charged LDH surface. The various composite materials of polymer beads and LDH nanocrystals are also discussed in the article by D.‐Y. Jung et al. on p. 5573 ff.
o‐Benzenedisulfonimide as a Reusable Brønsted Acid Catalyst for Ritter‐Type Reactions
Authors: Barbero Margherita , Bazzi Stefano , Cadamuro Silvano , Dughera Stefano 
Published: December 2008

AbstractReactions between various benzyl alcohols or tert‐butyl alcohol and nitriles were carried out in the presence of catalytic amounts (usually 10–20 mol‐%) of o‐benzenedisulfonimide as a Brønsted acid catalyst; the reaction conditions were mild and the yields of amides were good. The catalyst was easily recovered and purified, ready to be used in further reactions, with economic and ecological advantages.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Reciprocal Donor–Acceptor Selectivity: the Influence of the Donor O‐2 Substituent in the Regioselective Mannosylation of myo‐Inositol Orthopentanoate
Authors: Uriel Clara , Gómez Ana M. , López J. Cristóbal , Fraser‐Reid Bert 
Published: December 2008

AbstractThe regioselectivity in the glycosylation of myo‐inositol orthopentanoate with an n‐pentenyl orthoester (NPOE) and an armed thioglycoside as glycosyl donors has been examined. The NPOE displayed higher regioselectivity and its preferred site for glycosidation coincided with that for selective acylation with RCOCl/pyridine. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)