bluuebunny/crossref_metadata_2025_split huggingface dataset:
Management of shunt dysfunction using noninvasive intracranial pressure waveform monitoring: illustrative case
Authors: Bertani Raphael , Perret Caio , Koester Stefan , Santa Maria Paulo , Batista Savio , Cavicchioli Sophia de Andrade , Arita Sany Tomomi de Almeida Rocha , Monteiro Ruy , Lucchesi Gianne , Vasconcellos Fernando Augusto , Miranda Matheus , Paiva Wellingson Silva , Pinto Fernando Gomes 
Published: March 2024

BACKGROUND
Normal pressure hydrocephalus (NPH) treatment consists of using valves for drainage, as it is for hydrocephalus in general. Despite this, complications can occur, putting the patient at risk, and neurological monitoring is crucial.

OBSERVATIONS
A 61-year-old male, who had been diagnosed with NPH 3 years prior and was being treated with a ventriculoperitoneal shunt with a programmable valve, presented to the emergency department because of a traumatic brain injury due to a fall from standing height. No previous complications were reported. He had an altered intracranial pressure (ICP) waveform in the emergency room when monitored with the brain4care device, with a P2/P1 ratio of 1.6. Imaging helped to confirm shunt dysfunction. Revision surgery normalized the ratio to 1.0, and the patient was discharged. Upon return after 14 days, an outpatient analysis revealed a ratio of 0.6, indicating improvement.

LESSONS
In selected cases of NPH, noninvasive ICP waveform morphology analysis can be effective as a diagnostic aid, as well as in the pre- and postsurgical follow-up, given the possibility of comparing the values of ICP preoperatively and immediately postoperatively and the outpatient P2/P1 ratio, helping to manage these patients.
نشأة علم اللغة العام بين البحث العلمي والسياسة السائدة
Authors: نسيم بتول عباس 
Published: March 2024

لفتت انتباهي أمور تتعلق بتأسيس علم اللغة العام وازدهاره ، من جهة ، وبالصراعات السياسية والعسكرية من جهة أخرى ، وتوافقهما تاريخا وغايات ، مما دفعني ذلك إلى البحث في هذه القضية ، محاولة فهمها كما هي ، وفي التوصل إلى ما أراه مناسبا فيها ، وهو أن علم اللغة العام في أول تأسيسه كان ثمرة الطموح السلطوي لبعض الدول الأوربية ، ونزعتهم في السيطرة على العالم ، والصراع الطويل بين الدول المتقدمة في تلك السيطرة ، والذي بدا واضحا في الحربين العالميتين الأولى والثانية ، وما أفرزته من دمار شامل ، وخسائر بشرية ومادية ، يندى لها جبين الإنسانية على مر الأحقاب والأزمان .
ولا شك في أن اللغة هي إحدى وسائل السيطرة ، وتحقيق طموح الهيمنة ، إذا ما علمنا أن اللغة مقوم من مقومات الوطن ، ومفردة من مفردات المواطنة ، وهوية المجتمعات .
Concept for Parameter Design and Optimization of Surface Acoustic Wave Devices
Authors: Koigerov A. S. , Korlyakov A. V. 
Published: March 2024

Introduction. Bandpass filters on surface acoustic waves (SAW) are important components in frequency selection devices for receiving and transmitting electronic equipment. Among the variety of existing requirements for SAW filters, particular attention is paid to those for the quality of characteristics, including reduction of insertion losses, unevenness in the bandwidth, etc., and those for reducing the development time of the filter. Reduction in the development time along with a simultaneous reduction in expenses can be achieved through the application of preliminary computer simulation. This task can be implemented only through an integrated approach to developing a computer-aided design system capable of solving optimization problems with a large number of degrees of freedom.Aim. Development of a prototype of a fully functional complex for simulating and calculating SAW filters. Approbation of work on the creation of actual frequency filters on the example of resonator SAW filters with low losses on leaky SAWs. Development of a methodological approach to creation of a technology of computer-aided design of SAW filters using optimization algorithms.Materials and methods. The theoretical part of the work was carried out using statistical analysis methods, circuit theory, and coupled mode theory. In the course of the work, mathematical processing and calculation were carried out in the MATLAB environment.Results. A concept for creating a system of automated design of SAW filters with specified frequency characteristics was developed. An original method is proposed for optimizing the topology of SAW filter elements to obtain the maximum achievable frequency responses. The proposed approach was tested when calculating a resonator filter on leaky SAWs at 64° YX-cut lithium niobate.Conclusion. The proposed integrated approach to designing SAW filters allows a rapid and relatively accurate prediction of filter characteristics at the modeling stage, which has a significant advantage compared to conducting numerous real experimental studies or numerical studies in the presence of a large number of degrees of freedom.
Characteristics of the Radiating Element of a Planar Vivaldi Antenna Array with Improved Bandwidth
Authors: Bobkov I. V. , Yukhanov Yu. V. 
Published: March 2024

Introduction. The conventional approach to extending the operating frequency band of Vivaldi antenna arrays consists in increasing the radiating element length. However, this inevitably leads to an increase in the mass of the entire array, and, therefore, to a rapid growth in the cross-polarization level. Recent studies in this field have mainly focused on techniques for reducing the cross-polarization level. At the same time, the possibility of developing Vivaldi antenna arrays with an extended operating frequency band, primarily without changing the overall dimensions of the elements or the antenna array pitch, remains insufficiently studied.Aim. Design and study of the Vivaldi antenna radiating element that ensures operation of the array in a wider operating frequency band without increasing its overall dimensions and weight.Materials and methods. A numerical study of the characteristics of a unit-cell with periodic boundary conditions on the side faces was carried out in the ANSYS HFSS software. A comparative analysis of the unit-cell characteristics of the prototype antenna array and the proposed design was carried out.Results. The design of the Vivaldi antenna radiating element is presented. The influence of some geometric parameters on the characteristics of the antenna array is studied. A comparative analysis of the unit-cell characteristics of two infinite single-polarization antenna arrays based on a regular Vivaldi element and the proposed solution is carried out. The possibility of improving the antenna array bandwidth by 18.6 % and improving cross-polarization by 15 dB on certain frequencies without increasing the overall dimensions or the antenna array pitch is shown.Conclusion. The proposed Vivaldi antenna design makes it possible to extend its operating frequency band without increasing the overall dimensions. The results of the conducted numerical study should be used when developing antenna arrays based on the proposed solution.
Penyalahgunaan Narkotika Sebagai Suatu Tindak Pidana Dalam Tinjauan Kriminilogi Di Wilayah Hukum Polres Bintan
Authors: Hutagalung Evan Ivander , Siahaan Benny Enrico , Hakim Aqila Fikril 
Published: March 2024

Narcotics is like a double-edged knife which can be interpreted that the use of narcotics is good in the field of medicine but wrong when used illegally, causing criminal acts. This research examines the abuse of narcotics in the jurisdiction of Bintan Police based on criminological reviews. This research uses empirical research methods or field research with a descriptive qualitative approach. There are 2 problem formulations in this study, namely: What are the factors that cause narcotics abuse in the jurisdiction of Bintan Police Station? and How are efforts to overcome narcotics abuse in the jurisdiction of Bintan Police Station? The conclusion in this research is that weak self-control, low education, work environment and economic problems are the main factors causing narcotics abuse in the jurisdiction of Bintan Police Station. The countermeasures taken by Bintan Police are repressive efforts or prosecution efforts after the occurrence of criminal acts and preventive efforts, namely by conducting socialization, counseling, and establishing cooperation with community leaders, non-governmental organizations, and BNNK.
PENDAMPINGAN PENERAPAN STRATEGI PEMBELAJARAN TATAP MUKA TERBATAS DI PAUD KASIH IBU RUMBAI
Authors: Putri Azlin Atika , Bastian Adolf , Reswita Reswita 
Published: March 2024

Strategi pembelajaran sebagai segala usaha guru dalam menerapkan berbagai metode pembelajaran untuk mencapai tujuan yang diharapkan. Sebagai Mitra Dalam Pelaksanaan Program PKM ini adalah PAUD Kasih Ibu Kecamatan Rumbai. Berdasarkan analisis situasi dapat teridentifikasi beberapa permasalahan yang dihadapai oleh mitra, yaitu: Kurangnya pengetahuan pendidik dalam menerapkan strategi pembelajaran tatap muka terbatas. belum adanya pendampingan penerapan strategi pembelajaran tatap muka terbatas. Oleh sebab itu, kami tergerak untuk memberikan pendampingan penerapan strategi pembelajaran tatap muka terbatas agar Pendidik PAUD tersebut memiliki pengetahuan. Adapun mekanisme pelaksanaan Program Kemitraan Masyarakat ini memeiliki beberapa langkah yang terdiri dari 4 tahapan kegiatan; perencanaan, pelaksanaan, monitoring kegiatan, dan evaluasi. Setelah mengikuti kegiatan pengabdian masyarakat ini peserta mendapatkan wawasan dan pengetahuan yang lebih banyak lagi khususnya penerapan strategi pembelajaran tatap muka terbatas.
Effects of different rehabilitation modality on cardiopulmonary function in patients with acute coronary syndrome after revascularization
Authors: Chen Wanping , Feng Yan , Yu Meili , Zhang Zhaoguo , Wu Jiahui , Liu Wenxian , Gu Wei 
Published: March 2024

ObjectiveTo investigate the effects of different rehabilitation modalities on cardiopulmonary function in patients with acute coronary syndrome after revascularization.MethodsTwo randomized controlled trials were conducted. All patients were stable for more than 48 h and less than 1 week after revascularization for acute coronary syndrome and were randomly assigned to Group A (home-based rehabilitation group) or Group B (center guided home-based rehabilitation group). The cardiopulmonary exercise test was mainly performed before and 3 months after cardiac rehabilitation (at the end of intervention). The primary endpoints of the study were peak oxygen uptake (VO2peak), and the secondary endpoints were maximum metabolic equivalents (METs), anaerobic threshold exercise load (Load AT), maximal workload (Load max), and anaerobic threshold oxygen uptake (VO2 AT).ResultsA total of 106 patients were included in the study, with 47 patients in Group A (with 6 losses) and 50 patients in Group B (with 3 losses). There were no significant difference between the two groups in terms of age, gender, body mass index (BMI), left ventricular ejection fraction(LVEF), low-density lipoprotein cholesterol(LDL-C),cardiovascular risk factors. In Group A, no significant differences in CPET indices were observed before and after the intervention. In Group B, values of maximum metabolic equivalents (METs), peak heart rate (PHR), anaerobic threshold exercise load (Load AT), maximal workload (Load max), maximum ventilation per minute (VE max), peak oxygen uptake (VO2peak), anaerobic threshold oxygen uptake (VO2 AT) and maximum oxygen pulse (VO2/HRmax) were higher than those before the intervention (P &lt; 0.05). In addition, METs (max), Load AT, Load max, VO2 AT, and VO2peak in Group B were higher than those in group A (P &lt; 0.05). The change rates of VO2peak, METs(max), PHR, Load max, VO2 AT, VE max, VO2/HR(max) in the two groups were significantly different before and after intervention (P &lt;  0.05).ConclusionCardiac exercise rehabilitation is helpful for improving patients’ cardiopulmonary endurance and quality of life. Moreover, rehabilitation modalities with regular hospital guidance can improve cardiopulmonary function in a shorter period,which seems to be more effective than a complete home-based rehabilitation model.
Clinical Trial Registrationhttp://www.chictr.org.cn, identifier (ChiCTR2400081034).
Artificial intelligence based prediction model of in-hospital mortality among females with acute coronary syndrome: for the Jerusalem Platelets Thrombosis and Intervention in Cardiology (JUPITER-12) Study Group
Authors: Loutati Ranel , Perel Nimrod , Marmor David , Maller Tommer , Taha Louay , Amsalem Itshak , Hitter Rafael , Mohammed Manassra , Levi Nir , Shrem Maayan , Amro Motaz , Shuvy Mony , Glikson Michael , Asher Elad 
Published: March 2024

IntroductionDespite ongoing efforts to minimize sex bias in diagnosis and treatment of acute coronary syndrome (ACS), data still shows outcomes differences between sexes including higher risk of all-cause mortality rate among females. Hence, the aim of the current study was to examine sex differences in ACS in-hospital mortality, and to implement artificial intelligence (AI) models for prediction of in-hospital mortality among females with ACS.MethodsAll ACS patients admitted to a tertiary care center intensive cardiac care unit (ICCU) between July 2019 and July 2023 were prospectively enrolled. The primary outcome was in-hospital mortality. Three prediction algorithms, including gradient boosting classifier (GBC) random forest classifier (RFC), and logistic regression (LR) were used to develop and validate prediction models for in-hospital mortality among females with ACS, using only available features at presentation.ResultsA total of 2,346 ACS patients with a median age of 64 (IQR: 56–74) were included. Of them, 453 (19.3%) were female. Female patients had higher prevalence of NSTEMI (49.2% vs. 39.8%, p &lt; 0.001), less urgent PCI (&lt;2 h) rates (40.2% vs. 50.6%, p &lt; 0.001), and more complications during admission (17.7% vs. 12.3%, p = 0.01). In-hospital mortality occurred in 58 (2.5%) patients [21/453 (5%) females vs. 37/1,893 (2%) males, HR = 2.28, 95% CI: 1.33–3.91, p = 0.003]. GBC algorithm outscored the RFC and LR models, with area under receiver operating characteristic curve (AUROC) of 0.91 with proposed working point of 83.3% sensitivity and 82.4% specificity, and area under precision recall curve (AUPRC) of 0.92. Analysis of feature importance indicated that older age, STEMI, and inflammatory markers were the most important contributing variables.ConclusionsMortality and complications rates among females with ACS are significantly higher than in males. Machine learning algorithms for prediction of ACS outcomes among females can be used to help mitigate sex bias.
Cardiometabolic biomarker patterns associated with cardiac MRI defined fibrosis and microvascular dysfunction in patients with heart failure with preserved ejection fraction
Authors: Siggins Connor , Pan Jonathan A. , Löffler Adrián I. , Yang Yang , Shaw Peter W. , Balfour Pelbreton C. , Epstein Frederick H. , Gan Li-Ming , Kramer Christopher M. , Keeley Ellen C. , Salerno Michael 
Published: March 2024

IntroductionHeart failure with preserved ejection fraction (HFpEF) is a complex disease process influenced by metabolic disorders, systemic inflammation, myocardial fibrosis, and microvascular dysfunction. The goal of our study is to identify potential relationships between plasma biomarkers and cardiac magnetic resonance (CMR) imaging markers in patients with HFpEF.MethodsNineteen subjects with HFpEF and 15 age-matched healthy controls were enrolled and underwent multiparametric CMR and plasma biomarker analysis using the Olink® Cardiometabolic Panel (Olink Proteomics, Uppsala, Sweden). Partial least squares discriminant analysis (PLS-DA) was used to characterize CMR and biomarker variables that differentiate the subject groups into two principal components. Orthogonal projection to latent structures by partial least squares (OPLS) analysis was used to identify biomarker patterns that correlate with myocardial perfusion reserve (MPR) and extracellular volume (ECV) mapping.ResultsA PLS-DA could differentiate between HFpEF and normal controls with two significant components explaining 79% (Q2 = 0.47) of the differences. For OPLS, there were 7 biomarkers that significantly correlated with ECV (R2 = 0.85, Q = 0.53) and 6 biomarkers that significantly correlated with MPR (R2 = 0.92, Q2 = 0.32). Only 1 biomarker significantly correlated with both ECV and MPR.DiscussionPatients with HFpEF have unique imaging and biomarker patterns that suggest mechanisms associated with metabolic disease, inflammation, fibrosis and microvascular dysfunction.
Optimising high-throughput sequencing data analysis, from gene database selection to the analysis of compositional data: a case study on tropical soil nematodes
Authors: Wang Simin , Schneider Dominik , Hartke Tamara R. , Ballauff Johannes , de Melo Moura Carina Carneiro , Schulz Garvin , Li Zhipeng , Polle Andrea , Daniel Rolf , Gailing Oliver , Irawan Bambang , Scheu Stefan , Krashevska Valentyna 
Published: March 2024

IntroductionHigh-throughput sequencing (HTS) provides an efficient and cost-effective way to generate large amounts of sequence data, providing a very powerful tool to analyze biodiversity of soil organisms. However, marker-based methods and the resulting datasets come with a range of challenges and disputes, including incomplete reference databases, controversial sequence similarity thresholds for delimitating taxa, and downstream compositional data analysis. MethodsHere, we use HTS data from a soil nematode biodiversity experiment to explore standardized HTS data processing procedures. We compared the taxonomic assignment performance of two main rDNA reference databases (SILVA and PR2). We tested whether the same ecological patterns are detected with Amplicon Sequence Variants (ASV; 100% similarity) versus classical Operational Taxonomic Units (OTU; 97% similarity). Further, we tested how different HTS data normalization methods affect the recovery of beta diversity patterns and the identification of differentially abundant taxa.ResultsAt this time, the SILVA 138 eukaryotic database performed better than the PR2 4.12 database, assigning more reads to family level and providing higher phylogenetic resolution. ASV- and OTU-based alpha and beta diversity of nematodes correlated closely, indicating that OTU-based studies represent useful reference points. For downstream data analyses, our results indicate that loss of data during subsampling under rarefaction-based methods might reduce the sensitivity of the method, e.g. underestimate the differences between nematode communities under different treatments, while the clr-transformation-based methods may overestimate effects. The Analysis of Compositions of Microbiome with Bias Correction approach (ANCOM-BC) retains all data and accounts for uneven sampling fractions for each sample, suggesting that this is currently the optimal method to analyze compositional data.DiscussionOverall, our study highlights the importance of comparing and selecting taxonomic reference databases before data analyses, and provides solid evidence for the similarity and comparability between OTU- and ASV-based nematode studies. Further, the results highlight the potential weakness of rarefaction-based and clr-transformation-based methods. We recommend future studies use ASV and that both the taxonomic reference databases and normalization strategies are carefully tested and selected before analyzing the data.
Dietary Salicornia ramosissima improves the European seabass (Dicentrarchus labrax) inflammatory response against Photobacterium damselae piscicida
Authors: Machado Marina , Cruz Francisco , Cunha André , Ramos-Pinto Lourenço , Laranjeira Adriana , Pacheco Mário , Rocha Rui J. M. , Costas Benjamín 
Published: March 2024

IntroductionModern fish farming faces challenges in sourcing feed ingredients, most related with their prices, 21 availability, and specifically for plant protein sources, competition for the limited cultivation space for 22 vegetable crops. In that sense, halophytes have the added value of being rich in valuable bioactive compounds and salt tolerant. This study assessed the inclusion of non-food fractions of S. ramosissima in European seabass diets.MethodsDifferent levels (2.5%, 5%, and 10%) were incorporated into seabass diets, replacing wheat meal (diets ST2.5, ST5, and ST10) or without inclusion (CTRL). Experimental diets were administered to seabass juveniles (8.62 ± 0.63 g) for 34 and 62 days and subsequent inflammatory responses to a heat-inactivated Photobacterium damselae subsp. piscicida (Phdp) were evaluated in a time-course manner (4, 24, 48, and 72 h after the challenge). At each sampling point, seabass haematological profile, plasma immune parameters, and head-kidney immune-related gene expression were evaluated.ResultsAfter both feeding periods, most parameters remained unaltered by S. ramosissima inclusion; nonetheless, seabass fed ST10 showed an upregulation of macrophage colony-stimulating factor 1 receptor 1 (mcsf1r1) and cluster of differentiation 8 (cd8β) compared with those fed CTRL after 62 days of feeding. Regarding the inflammatory response, seabass fed ST10 showed lower plasma lysozyme levels than their counterparts fed ST2.5 and ST5 at 24 h following injection, while 4 h after the inflammatory stimulus, seabass fed ST10 presented higher numbers of peritoneal leucocytes than fish fed CTRL. Moreover, at 4 h, fish fed ST2.5, ST5, and ST10 showed a higher expression of interleukin 1β (il1β), while fish fed ST5 showed higher levels of ornithine decarboxylase (odc) than those fed CTRL. An upregulation of macrophage colony-stimulating factor 1 receptor 1 (mcsf1r1) and glutathione peroxidase (gpx) was also observed at 72 h in fish fed ST10 or ST5 and ST10 compared with CTRL, respectively.DiscussionIn conclusion, incorporating up to 10% of the non-food fraction S. ramosissima in feed did not compromise seabass growth or immune status after 62 days, aligning with circular economy principles. However, S. ramosissima inclusion improved the leucocyte response and upregulated key immune-related genes in seabass challenged with an inactivated pathogen.
Determinants of immunoglobulin G responses to respiratory syncytial virus and rhinovirus in children and adults
Authors: Guillien Alicia , Niespodziana Katarzyna , Mauclin Marion , Boudier Anne , Varraso Raphäelle , Leynaert Bénédicte , Dumas Orianne , Le Moual Nicole , Schlederer Thomas , Bajic Maja , Borochova Kristina , Errhalt Peter , Vernet Raphaël , Nadif Rachel , Bousquet Jean , Bouzigon Emmanuelle , Valenta Rudolf , Siroux Valérie 
Published: March 2024

IntroductionExposure to respiratory viruses is a significant cause of morbidity and affects virus-specific antibody levels. Little is known about determinants associated with immune response to these viruses. We aimed to investigate the determinants of respiratory syncytial virus (RSV)- and rhinovirus (RV)- specific IgG responses in both children and adults.MethodsThe study is based on the EGEA cohort, composed of 530 samples of children in EGEA1 (1991-95) and 1241 samples of adults in EGEA2 (2003-07). Cumulative RV-specific IgG levels (species A, B and C) and IgG levels to RSV-G protein were measured by using micro-array technoloy. Multiple linear mixed models (random effect to account for familial dependence) were performed to assess associations between age, sex, body mass index (BMI), tobacco smoke exposure and season of blood sampling with RSV-and RV-specific IgG levels.ResultsIn children (11.1 ± 2.8 years old, 57% boys), higher RV-specific IgG levels were associated with older age (only for RV-B), female sex and lower BMI, while only older age was associated with higher RSV-specific IgG levels. In adults (43.5 ± 16.7 years old, 48% men), younger age, female sex, lower BMI, active smoking and all seasons except summer were associated with higher RV-specific IgG levels. Older age, active smoking and all seasons except summer were associated with higher RSV-specific IgG levels.ConclusionPersonal and seasonal determinants of RSV- and RV-specific IgG levels seem to vary according to the respiratory virus type and between children and adults, suggesting different patterns of responses along the life course.