bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early postoperative pancreatic endocrine function after segmental and pancreaticoduodenal allotransplantation in nonimmunosuppressed primates
Authors: Du Toit Don F. , Heydenrych Jacobus J. , Smit Ben , Louw Gabriel , Zuurmond Theuns , Laker Lida , Els Daniel , Weideman André , Wolfe‐Coote Sonja , Toit Lorraine Du , Davids Henry 
Published: February 2007

AbstractIn this study we evaluated the short‐term hormonal effects of segmental and whole pancreatic allotransplantation on the glucose intolerance produced by hemipancreatectomy in the primate. In hemipancreatectomized animals without grafts the K‐values were reduced to 0.6 ± 0.05, plasma insulin increased from 27.5 ± 2.5 to 63.5 ± 6.3 μU/ml, and glucagon levels declined from 252 ± 29.9 to 216.5 ± 33.0 pg/ml. Hemipancreatectomized segmental allograft recipients rendered K‐values of 0.79 ± 0.05, plasma insulin increased from 19.98 ± 3.43 to 66.0 ± 17.03 μU/ml, and glucagon release declined from 395.6 ± 63.0 to 226.2 ± 37.6 pg/ml during IVGTT postoperatively. Hemipancreatectomized, pancreaticoduodenal allograft recipients rendered K‐values of 0.82 ±0.1, results not significantly different from hemipancreatectomized or segmental allograft recipients. Plasma insulin increased from 29.5 ± 4.0 to 186.0 ± 25.0 μU/ml, and glucagon release declined from 1,087.0 ± 31.6 to 656.0 ± 12.7 pg/ml. In summary, segmental pancreatic allotransplantation could not, in the short‐term, restore the reduced K‐values and hypoinsulinaemia in hemipancreatectomized primates to that of normal, unstressed controls. Although K‐values of hemipancreatectomized recipients were not significantly improved, whole pancreas transplantation resulted in improved insulin release and hyperglucagonaemia during IVGTT when compared to segmental allograft recipients. The unexpected findings of hypoinsulinaemia and hyperglucagonaemia in both transplant groups may only reflect a function of the stressed state of the animals in the immediate postoperative phase.
Augmentation of lymphoproliferative activity of tumor‐bearing BALB/c mice to soluble tumor antigens by surgical manipulation: The possible role of macrophages
Authors: Laing Calbert A. , Japal Knoxley M. , Baker Mark E. 
Published: February 2007

AbstractLymphoproliferative activity was assessed by 3H‐thymidine incorporation in spleen cells of mammary tumor bearing BALB/c mice, mice which had their tumors surgically removed, and mice with sham surgery after stimulation in vitro with a soluble extract of syngeneic tumor antigens. Surgical removal of tumors caused an average of 65 % decline in reactivity at 5 days postoperative as compared to reactivity of animals with their tumors intact. Sham surgery caused an average of 33% elevation in reactivity. Macrophages added to cultures at spleen cell/macrophage ratio of 100: 1 caused an average 171%, 59%, and 12% elevation in the activity of surgery, tumor‐bearing, and sham‐surgery animals, respectively. Surgical manipulation of tumor‐bearing mice, therefore, augmented in situ the ability of spleen cells to exhibit lymphoproliferative activity to a soluble syngeneic antigenic extract in vitro, possibly by a mechanism involving the activation of macrophages and requiring the presence of a sizable antigenic load.
Diagnostic histochemical and immunohistochemical studies in malignant mesothelioma
Authors: Lucas Joel G. , Tuttle Steven E. 
Published: February 2007

AbstractThis study was undertaken to evaluate the relative utility of histochemical and immunohistochemical stains in diagnosing malignant mesothelioma of the thorax. We performed a battery of histochemical stains, including periodic acid Schiff (PAS) with and without diastase, mucicarmine, colloidal iron (Coll Fe) with and without hyaluronidase, and immunohistochemical stains for keratin and carcinoembryonic antigen (CEA) on 12 pleural mesothelioma specimens obtained from 11 patients, five primary pulmonary adenocarcinomas, and one metastatic adenocarcinoma each to pleura and pericardium. All diagnoses were established by autopsy or through clinical and surgical evaluation. The diagnosis of mesothelioma was established following rigid anatomic criteria. All tissue was formalin fixed and paraffin embedded. Commercially available reagents and antisera were used in all cases. Results showed a high rate of positivity for keratin and hyaluronidase‐sensitive Coll Fe in the mesotheliomas while adenocarcinomas were uniformly positive for CEA and keratin and generally positive for PAS‐D (diastase) and mucicarmine. Mesotheliomas were negative for CEA, mucin, and PAS‐D. Positive keratin staining was also seen in the spindle cell components of mesotheliomas. Immunohistochemical stains often added significantly to our ability to establish the diagnosis of mesothelioma with confidence, since they were more frequently and more clearly positive than histochemical stains.
Colorectal carcinoma in young adults: An autopsy study
Authors: Sarma Deba P. 
Published: February 2007

AbstractAutopsy records of ten patients aged 40 or younger with colorectal carcinoma were reviewed. The local and metastatic spread of the cancer was similar to that seen in colorectal cancers occurring in older people. Colorectal cancer in young people is biologically not more aggressive or virulent than that in older patients.
Relationship of nuclear appearance to stromal invasion in human breast cancer
Authors: Bell C. D. , Stadler J. , Michowitz M. , Inbar M. 
Published: February 2007

AbstractTwo biopsies of intraductal and invasive lobular carcinoma of the breast and 11 biopsies of intraductal and invasive carcinoma of the breast were examined by automated micromensurative techniques for mean nuclear area of carcinoma cells in intraductal and in invasive compartments. The nuclei of invasive carcinoma cells tended to be smaller when they invaded stroma as single cells or as “thin strands” than when they invaded as part of large sheets of cells. Cells in direct apposition with the stroma usually had smaller nuclei than cells which were found centrally in large confluent sheets of cells. Intraduct carcinoma cells approached, in size, invasive cells which formed confluent sheets, rather than cancer cells which invaded as single cells. The nuclei of cells which invaded in small groups were usually darker than those of cells in confluent sheets, which were usually more vesicular.
Synchronous and metachronous colon lesions in squamous cell carcinoma of the anal canal
Authors: Klompje Jan , Petrelli Nicholas J. , Herrera Lemuel , Mittelman Arnold 
Published: February 2007

AbstractThe charts of 79 patients with a histologic diagnosis of squamous cell carcinoma of the anal canal were reviewed to determine the incidence of synchronous and/or metachronous colon lesions. Forty‐six patients underwent an adequate preoperative evaluation of the colon and rectum. Ten patients underwent colonoscopy, 33 patients underwent a barium enema, and three patients underwent colonoscopy and a barium enema. In this group six adenomatous polyps and three hyperplastic polyps were discovered. An adenocarcinoma of the sigmoid colon was found in another patient six months prior to the diagnosis of a squamous cell carcinoma of the anal canal. Twenty‐three patients had follow‐up evaluation of the large bowel for metachronous lesions following treatment of the squamous cell carcinoma of the anal canal. Ten patients underwent colonoscopy, three patients had a barium enema, and ten autopsies were available for analysis. In this group metachronous lesions consisted of two adenomatous polyps and one hyperplastic polyp.
Extra‐adrenal paraganglioma and pulmonary chondroma: A case report and review of the literature
Authors: Keyhani‐Rofagha Sedigheh , O'dorisio THOMAS M. , Lucas Joel G. , Fontana Mary Beth , Tuttle Steven E. 
Published: February 2007

AbstractThis report describes the findings of an extra‐adrenal paraganglioma and chondroma of the lung in an elderly man. Tissue analysis of the paraganglioma showed a high level of catecholamines, as well as the presence of somatostatin and small amounts of other peptide hormones. Immunoper‐oxidase staining demonstrated the distribution of peptide hormones in the tumor. This case illustrates two important points. First, it confirms the ability of paraganglionic tissue to secrete peptide hormones. Secondary, it adds yet another case to the unusual group of patients described by Carney.
Breast carcinoma post‐augmentation mammaplasty: Therapy with limited surgery and radiation
Authors: Lafreniere Rene , Ketcham Alfred S. 
Published: February 2007

AbstractDue to the recent surgical and technical developments in aesthetic surgery and occasional dissatisfaction of women with their external contour, augmentation mammaplasty has become a common occurrence in the surgical practice of the aesthetic surgeon. Breast carcinomas, incidentally associated with augmentation mammaplasty, have been sporadically reported in the literature and have all been treated with a mastectomy when resection was possible. We present a case of breast carcinoma occurring 5 years after augmentation mammaplasty performed with silicone‐gel‐filled implants. Therapy of this carcinoma was achieved through a segmental mastectomy followed by postoperative radiation. The patient remains well 15 months postoperatively. A large number of breast implants are performed each year and the likelihood of a higher incidence of incidental breast carcinomas seen with implants is certainly possible as these patients become older; thought should be given to the notion that possibly not all of these cases need to be managed with radical surgery.
Torre's syndrome in association with premalignant and malignant tumors and suspected familial polyposis
Authors: Maipang Tanaphon , Herrera‐Ornelas L. , Sanford C. , Vasquez Michael , Petrelli Nicholas , Mittelman Arnold 
Published: February 2007

AbstractTorre's syndrome was diagnosed in a patient with the clinical characteristics of familial polyposis coli, an association, that to our knowledge, has not been reported previously.
Bladder cancer detection and surveillance: Carcinoembryonic antigen as a monitor of neoplastic transformation
Authors: Boileau Michel , Swartz Douglas , Schmidt Karmen , Schmidt Waldemar 
Published: February 2007

AbstractRoutine cytopathology of exfoliated urothelial cells will identify only 70% of patients with transitional cell carcinoma (TCC) because most welldifferentiated bladder tumors are not detected. Carcinoembryonic antigen (CEA) was identified on urothelial cancer cells from 66% of patients with grade I TCC, 65% with grade II TCC, 65% with grade III TCC, and 80% of patients with CIS. Immunoperoxidase labelling of CEA can enhance the sensitivity of exfoliative cytology.
Lung cancer classification: The relationship of disease extent and cell type to survival in a clinical trials population
Authors: Mountain Clifton F. , Lukeman John M. , Hammar Samuel P. , Chamberlain Dean W. , Coulson Walter F. , Page David L. , Victor Thomas A. , Weiland Louis H. ,   LUNG CANCER STUDY GROUP PATHOLOGY COMMITTEE
Published: February 2007

AbstractThe staging and histologic cell type of patients in the Lung Cancer Study Group (LCSG) clinical trials program are reviewed and confirmed or resolved at the reference center for anatomic and pathologic classification of lung cancer. A high level of consistency in classification has been achieved through the use of criteria that minimize intraobserver variability. The data obtained from the review project have been used to characterize the relationship of disease extent and cell type to survival in the clinical trials population. Survival characteristics were generated for 1,121 patients who underwent apparent complete resection of nonsmall cell lung cancer and were subsequently entered into various protocols to receive either adjuvant treatment or no further therapy. The end results study provides some insight regarding the biological behavior of squamous cell carcinoma and adenocarcinoma of the lung in terms of the anatomic extent of disease at the time of apparent complete resection. Patients with squamous cell carcinoma had an outcome superior to that of patients with adenocarcinoma in every TNM subset. The differences in survival according to these major cell types were significant overall and in the T1 NO, T1 N1, and T2 N1 subsets but not in the TNM subsets in stage III disease. Histologic cell type and extent of disease are important factors in survival expectations; thus the accuracy and reproducibility of these classifications plays a significant role in the evaluation of differing modalities of treatment.
Malignant peripheral primitive neuroectodermal tumor of the uterus
Authors: Rose Peter G. , O'toole Robert V. , Keyhani‐Rofagha Sedigeh , Qualman Stephen , Boutselis John G. 
Published: February 2007

AbstractPeripheral primitive neuroectodermal tumor (PPNET) is rare, occurring most often in young adults. Approximately 50 cases have been reported, with only four cases involving the female genital tract. We report the fifth patient. The term “PPNET” should be used only for tumors with neuroectodermal elements exclusively that occur at sites outside the central and sympathetic nervous system. The pathologic differential diagnoses include rhabdomyosarcoma, immature malignant teratoma, small cell carcinoma of the cervix, and ganglioneuroma. Therapy for this tumor has varied, and no effective regimen has been established.
Effective management of extremity cancers using cisplatin and etoposide in isolated limb perfusions
Authors: Roseman James M. 
Published: February 2007

AbstractFour cases of extremity cancers received effective management with cisplatin and etoposide via isolated limb perfusion. They demonstrated minimal, if any, soft tissue damage. This result counters the theory that a caustic response is a prerequisite for successful therapy. This characteristic allows for simultaneous surgical resection with regional, isolated limb perfusion of potent cytotoxic agents without increased morbidity from tissue necrosis, a common consequence of previously used drugs. There is no apparent affect on wound healing, even in cases involving extensive, radical operative procedures.
Surgery for carcinoma of the breast in women over 70 years of age
Authors: Amsterdam Elazar , Birenfeld Shlomo , Gilad Addi , Krispin Mayer 
Published: February 2007

AbstractA review of 100 women over 70 years of age treated for breast carcinoma is reported. The short‐ and long‐term results of treatment were evaluated with a median follow up of 4. 7 years. Due to our aggressive approach, only 11% of this group died from breast cancer, and the 5‐year survival rate was 51%, including all stages of the disease. The result of this study indicates that elderly women with breast cancer should be treated by surgical methods that offer the best chance of cure, regardless of patient's age.
Diabetes in pancreatectomized baboons: A model for pancreatin transplantation studies
Authors: Toit Don F. Du , Heydenrych Jacobus J. , Louw Gawie , Zuurmond Theuns , Laker Lida , Smit Ben , Els Daniel , Weideman André , Davids Henry , Wolfe‐Coote Sonja , Toit Lorraine Du 
Published: February 2007

AbstractThis study was designed to assess plasma glucose levels (PLG) and insulin release in totally pancreatectomized baboons when challenged with intravenous glucose administration (IVGTT). Ten animals (Pupio ursinus) were used and duodenectomy was intentionally avoided. The PLG at death was 18.0 ∓ mmol/L, and the mean K‐value within 3 days after pancreatectomy was 0.4% ∓ 0.2%, indicating a significant impairment of glucose disappearance from the blood when compared to the control animals (P < 0.01). Plasma insulin levels before and after stimulation with glucose were below the lowest level of insulin assay sensitivity. We conclude that in the primate, as in the dog, surgical pancreatectomy produced a reliable diabetic model, which is uniformly lethal if left untreated.
Prognosis after resection of non‐small cell lung cancer of the right middle lobe
Authors: Peleg Haran , Antkowiak Joseph G. , Lane Warren W. , Regal Anne‐Marie , Takita Hiroshi 
Published: February 2007

AbstractIn a previous study at Roswell Park Memorial Institute, it was noted that in patients whose resected non‐small‐cell lung cancer had originated in the right middle lobe, the prognosis was much worse than when it had originated in any other lobe. A review of a longer period and exclusion of patients who might introduce a bias resulted in a group of 18 patients whose fate was compared to the findings reported in other comparable series. Three out of those are alive at 8‐96 months after operation. Five‐year survival was 22% (30% counting only survivors of the operations). These findings indicate that the results of surgery for non‐small‐cell carcinoma of the right middle lobe fall within the lower range of lung cancer generally.
Phase II trial of cis‐diamminedichloroplatinum (cis‐platinum), vincristine, and peplomycin for advanced squamous cell carcinoma
Authors: Tamura Kazuo , Araki Yasuhiko , Tateyama Hiromichi , Maeda Moritaka , Seita Masashi 
Published: February 2007

AbstractAdvanced squamous cell carcinoma of the head and neck, lung, esophagus, and uterine cervix is still a challenging cancer to the medical practice. We have treated 23 such patients with a combination of cis‐platinum, vincristine, and peplomycin. Cis‐platinum was given at a dose of 60 mg/m2 on day 1, and 1.0 mg/m2 of vincristine was given on day 3, followed 6 hours later by peplomycin 10 mg/day by continuous infusion iv or sc over the next 5 days. This combination was given every 3 weeks. The overall response rate was 71% for 17 evaluable patients, including one complete response. The median duration of response and survival was 2 and 5 months, respectively. Six other patients with esophageal and cervical carcinoma were treated with two cycles of this combination followed by radical radiation therapy or surgery. Five of them achieved significant response prior to radical treatment. Major side effects were nausea, vomiting, alopecia, and mild myelotoxicity, which were acceptable. This regimen, with a high response rate and acceptable toxicity, warrants further investigation.
NB rat bladder cancer model: Evaluation of the subrenal capsular assay system
Authors: Drago Joseph R. , Nesbitt John A. 
Published: February 2007

AbstractSince 1978 this laboratory unit has evaluated the Nb rat prostate adenocarcinoma model. More recently, over a 15‐month period we have studied the Nb rat number one bladder tumor, a spontaneously appearing tumor in an aged female noble rat. Initial chemotherapeutic experiments have been carried out, revealing activity of this tumor to cyclophosphamide. Herein we report the feasibility of utilizing the subrenal capsular assay in this model. The advantage of this system is that one is able to determine the effect of chemotherapy in a very short time, i.e., 7 days. This method may save considerable expense and may serve as a useful projector for potential future chemotherapeutic trials of bladder cancer. In this assay system, cyclophosphamide, adriamycin, and cis‐platinum and methotrexate did result in a significant decrease in tumor volume change. This change paralleled the results that we had seen in the past from the use of chemotherapy with cyclophosphamide alone in treatment of subcutaneous tumor nodules of bladder carcinoma. Further exploration of this method is warranted from a time efficiency as well as from a cost standpoint.
Solitary malignant schwannoma of the pancreas: Report of a case and ultrastructural examination
Authors: Eggermont Alexander , Vuzevski Vojislav , Huisman Margriet , De Jong Koert , Jeekel Johannes 
Published: February 2007

AbstractPrimary malignant schwannoma of the pancreas is rare. The reported patient, a 40‐year‐old white female, presented with obstructive jaundice and a large palpable mass in the upper abdomen. A Whipple procedure was performed. Electron microscopic examination of the tumor established the Schwann cell origin of the neoplasm by demonstrating basement membranes, junctional complexes, and interdigitating cytoplasmic extensions infested with basal lamina, dense neurosecretory‐like granules, and axon‐like structures. The inadequacy of light microscopic examination alone for establishing the diagnosis with certainty is discussed. Review of the literature revealed only one case of a malignant schwannoma of the pancreas that was not resected. This is the first report confirmed by ultrastructural examination.
Prognostic significance of lymph vessel involvement in gastric cancer
Authors: Kawasumi Hiroki , Makino Masato , Takebayashi Masataka , Yurugi Eiichi , Okamoto Tsuneyuki , Kimura Osamu , Nishidoi Hideaki , Kaibara Nobuaki , Koga Shigemasa 
Published: February 2007

AbstractWe studied the prognostic significance of lymph vessel involvement in the gastric wall in 226 patients with advanced gastric cancer. There was no close correlation between the gross morphology of the cancer and the incidence of lymph vessel invasion. However, the more severe the degree of lymph vessel involvement, the higher was the incidence of lymph node metastasis. Severe lymph vessel invasion was found most frequently in poorly differentiated adenocarcinoma of the medullary type. Among patients with scirrhous carcinoma there were some in whom lymph vessel involvement was overlooked on routine histologic examination. Because the depth of lymph vessel invasion of the gastric wall was significantly related to the clinical course, we consider this to be of supplementary predictive value.
Postradiation slipped capital femoral epiphyses (SCFE)
Authors: Sabio Hernan , Sussman Michael , Levien Michael 
Published: February 2007

AbstractThis study details the case reports of two children who developed slipped capital femoral epiphyses (SCFE) after receiving external irradiation. The clinical and diagnostic features of postradiation SCFE are reviewed and discussed. Guidelines for the management of children who receive pelvic irradiation are presented.
Cellular blue nevus simulating metastatic melanoma: Report of an unusually large lesion associated with nevus‐cell aggregates in regional lymph nodes
Authors: Sterchi J. Michael , Muss Hyman B. , Weidner Noel 
Published: February 2007

AbstractA young Caucasian woman had a large area of blue‐gray discoloration on the flank and palpable axillary lymph nodes. The discolored area had enlarged during a recent pregnancy, contained multiple subcutaneous nodules, demonstrated increased cellularity and mitotic activity, and was associated with an axillary lymph node containing black streaks within the capsule. Although the lesion was initially considered to be a metastatic malignant melanoma, re‐evaluation showed it to be a benign cellular blue nevus with benign nevus‐cell aggregates within a regional lymph node. We report this case to emphasize how cellular blue nevus can simulate malignant melanoma and to increase physician awareness of this benign variant of melanocytic nevus so that inappropriate surgery and chemotherapy can be avoided.