bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrative Medicine in Hematology/Oncology: Benefits, Ethical Considerations, and Controversies
Authors: Rosenthal David S. , Dean-Clower Elizabeth 
Published: November 2005

Abstract
Integrative Medicine (IM), a newly emerging field, has evolved from Complementary and Alternative Medicine (CAM). CAM refers to diverse medical and health care systems, practices, and products that are not presently considered part of conventional medicine and generally have limited scientific evidence. In the US, CAM is a multi-billion dollar, unregulated industry with potential benefits and risks to consumers, including cancer patients, who are high utilizers of complementary therapies. Patients’ CAM use often is unsupervised by physicians, yet patients need the advice and guidance of their hematologists/oncologists as part of total cancer care. Ethical and legal issues physicians need to address include inquiring about and educating patients regarding potential interactions (e.g., drug-herb, radiation-antioxidant) or product contaminants, while discussing other therapies that may alleviate symptoms and/or improve quality of life. Administratively, CAM offerings in medical settings require relevant policies and procedures, such as properly credentialing practitioners and providing financial assistance counseling for those who cannot afford fee-for-service. Unlike “Alternative Medicine,” the goal of IM is to combine mainstream medical therapies and CAM therapies (e.g., acupuncture, meditation, music therapy) that have some high-quality scientific evidence of safety and effectiveness. The Society for Integrative Oncology (SIO), a new international organization of oncology professionals studying and integrating effective complementary therapies in cancer care, serves as a forum for presenting scientific data on these therapies while emphasizing the importance of developing infrastructure that promotes IM principles and practices. The ultimate goal is to develop multidisciplinary expertise and therapeutic synergy between conventional and complementary therapies.
Bone Marrow Failure: A Child Is Not Just a Small Adult (But an Adult Can Have a Childhood Disease)
Authors: Alter Blanche P. 
Published: November 2005

Abstract
Aplastic anemia may be inherited or acquired. The distinction between these lies not in the age of the patient, but in the clinical and laboratory diagnoses. Adult hematologists must consider adult presentations of the inherited disorders, in order to avoid incorrect management of their patients. Physicians for adult patients must also realize that children with inherited disorders now survive to transition into their care. The major inherited bone marrow failure syndromes associated with development of pancytopenia include Fanconi anemia, dyskeratosis congenita, Shwachman-Diamond syndrome, and amegakaryocytic thrombocytopenia. The ages at presentation are highly variable, but often include individuals of adult age who have previously undiagnosed Fanconi anemia or dyskeratosis congenita. Many of the genes responsible for these disorders have been identified (12 Fanconi anemia genes, 3 dyskeratosis congenita genes, and 1 each for Shwachman-Diamond syndrome and amegakaryocytic thrombocytopenia). A high index of suspicion and specific testing of children or adults with what appears to be acquired aplastic anemia may identify inherited disorders. Correct classification of patients with aplastic anemia of any age is mandatory for their appropriate management.
Phylogenetic analyses suggest reverse splicing spread of group I introns in fungal ribosomal DNA
Authors: Bhattacharya Debashish , Reeb Valérie , Simon Dawn M , Lutzoni François 
Published: November 2005

Abstract

Background
Group I introns have spread into over 90 different sites in nuclear ribosomal DNA (rDNA) with greater than 1700 introns reported in these genes. These ribozymes generally spread through endonuclease-mediated intron homing. Another putative pathway is reverse splicing whereby a free group I intron inserts into a homologous or heterologous RNA through complementary base-pairing between the intron and exon RNA. Reverse-transcription of the RNA followed by general recombination results in intron spread. Here we used phylogenetics to test for reverse splicing spread in a taxonomically broadly sampled data set of fungal group I introns including 9 putatively ancient group I introns in the rDNA of the yeast-like symbiont Symbiotaphrina buchneri.

Results
Our analyses reveal a complex evolutionary history of the fungal introns with many cases of vertical inheritance (putatively for the 9 introns in S. buchneri) and intron lateral transfer. There are several examples in which introns, many of which are still present in S. buchneri, may have spread through reverse splicing into heterologous rDNA sites. If the S. buchneri introns are ancient as we postulate, then group I intron loss was widespread in fungal rDNA evolution.

Conclusion
On the basis of these results, we suggest that the extensive distribution of fungal group I introns is at least partially explained by the reverse splicing movement of existing introns into ectopic rDNA sites.
Maximal COX-2 and ppRb expression in neurons occurs during early Braak stages prior to the maximal activation of astrocytes and microglia in Alzheimer's disease
Authors: Hoozemans Jeroen JM , van Haastert Elise S , Veerhuis Robert , Arendt Thomas , Scheper Wiep , Eikelenboom Piet , Rozemuller Annemieke JM 
Published: November 2005

Abstract
Neuronal expression of cyclooxygenase-2 (COX-2) and cell cycle proteins is suggested to contribute to neurodegeneration during Alzheimer's disease (AD). The stimulus that induces COX-2 and cell cycle protein expression in AD is still elusive. Activated glia cells are shown to secrete substances that can induce expression of COX-2 and cell cycle proteins in vitro. Using post mortem brain tissue we have investigated whether activation of microglia and astrocytes in AD brain can be correlated with the expression of COX-2 and phosphorylated retinoblastoma protein (ppRb). The highest levels of neuronal COX-2 and ppRb immunoreactivity are observed in the first stages of AD pathology (Braak 0–II, Braak A). No significant difference in COX-2 or ppRb neuronal immunoreactivity is observed between Braak stage 0 and later Braak stages for neurofibrillary changes or amyloid plaques. The mean number of COX-2 or ppRb immunoreactive neurons is significantly decreased in Braak stage C compared to Braak stage A for amyloid deposits. Immunoreactivity for glial markers KP1, CR3/43 and GFAP appears in the later Braak stages and is significantly increased in Braak stage V-VI compared to Braak stage 0 for neurofibrillary changes. In addition, a significant negative correlation is observed between the presence of KP1, CR3/43 and GFAP immunoreactivity and the presence of neuronal immunoreactivity for COX-2 and ppRb. These data show that maximal COX-2 and ppRb immunoreactivity in neurons occurs during early Braak stages prior to the maximal activation of astrocytes and microglia. In contrast to in vitro studies, post mortem data do not support a causal relation between the activation of microglia and astrocytes and the expression of neuronal COX-2 and ppRb in the pathological cascade of AD.
Spectral decomposition of seismic data with continuous-wavelet transform
Authors: Sinha Satish , Routh Partha S. , Anno Phil D. , Castagna John P. 
Published: November 2005

This paper presents a new methodology for computing a time-frequency map for nonstationary signals using the continuous-wavelet transform (CWT). The conventional method of producing a time-frequency map using the short time Fourier transform (STFT) limits time-frequency resolution by a predefined window length. In contrast, the CWT method does not require preselecting a window length and does not have a fixed time-frequency resolution over the time-frequency space. CWT uses dilation and translation of a wavelet to produce a time-scale map. A single scale encompasses a frequency band and is inversely proportional to the time support of the dilated wavelet. Previous workers have converted a time-scale map into a time-frequency map by taking the center frequencies of each scale. We transform the time-scale map by taking the Fourier transform of the inverse CWT to produce a time-frequency map. Thus, a time-scale map is converted into a time-frequency map in which the amplitudes of individual frequencies rather than frequency bands are represented. We refer to such a map as the time-frequency CWT (TFCWT). We validate our approach with a nonstationary synthetic example and compare the results with the STFT and a typical CWT spectrum. Two field examples illustrate that the TFCWT potentially can be used to detect frequency shadows caused by hydrocarbons and to identify subtle stratigraphic features for reservoir characterization.
Acute Chemotherapy-Induced Cardiovascular Changes in Patients With Testicular Cancer
Authors: Nuver Janine , Smit Andries J. , van der Meer Jan , van den Berg Maarten P. , van der Graaf Winette T.A. , Meinardi Martin T. , Sleijfer Dirk Th. , Hoekstra Harald J. , van Gessel Anne I. , van Roon Arie M. , Gietema Jourik A. 
Published: November 2005

Purpose After cisplatin- and bleomycin-containing chemotherapy for testicular cancer, part of the patient population will develop acute or long-term cardiovascular toxicity. It is largely unknown whether standard tests can be used to assess chemotherapy-induced cardiovascular changes. Patients and Methods In 65 testicular cancer patients (median age, 27 years; range, 18 to 48 years), we measured the following cardiovascular parameters before and within 10 weeks after completion of cisplatin-based chemotherapy: platelet numbers, plasma levels of hemostatic and fibrinolytic factors, 24-hour ambulatory blood pressure, baroreflex sensitivity, intima-media thickness of the common carotid artery, and flow-mediated vasodilation of the brachial artery. Results Compared with prechemotherapy values, the intima-media thickness of the carotid artery and plasma von Willebrand factor levels increased significantly after treatment. Platelet numbers and plasma levels of other hemostatic and fibrinolytic factors did not appear to change significantly. Blood pressure decreased significantly, but flow-mediated vasodilation and baroreflex sensitivity did not change. Conclusion In testicular cancer patients treated with cisplatin-based chemotherapy, we found an increase in plasma von Willebrand factor levels and in the intima-media thickness of the carotid artery. These changes may indicate chemotherapy-induced vascular damage and be of prognostic significance for the development of cardiovascular complications in the long term.
Simulation der zerebralen Hämodynamik zur präoperativen Risikoeinschätzung (Simulation of Cerebral Hemodynamics for Preoperative Risk-estimation)
Authors: Roessler Florian C. , Reith Wolfgang , Siegel Günter 
Published: November 2005

Abstract
Vorgestellt wird ein Verfahren zur präoperativen, nichtinvasiven Risikoabschätzung von Gefäßverschlüssen bei neuroradiologischen oder neurochirurgischen Interventionen. Es basiert auf einer computergestützten, zeitvarianten, pulsatilen, nichtlinearen und individuellen Simulation der Hämodynamik intrakranieller Gefäßsysteme. Auf diese Weise sollen riskante, invasive Diagnoseverfahren ersetzt werden.
Ein Ansatz zur dynamischen Modellierung der Genexpression mit Shegalkin-Polynomen (An Appraoch to Dynamic Modelling of Gene Expression by Zhegalkin Polynomials)
Authors: Lichtenberg Gerwald , Faisal Saadia , Werner Herbert 
Published: November 2005

Abstract
Der Beitrag beschreibt einen neuen Ansatz zur Modellierung des dynamischen Verhaltens der Genexpression. Im Gegensatz zu bekannten Modellbildungsmethoden können mit Hilfe der vorgestellten Methode sowohl diskrete biologische Regeln, wie z.B. die kanalisierende Eigenschaft der Gen-Wechselwirkung als auch kontinuierliche Messdaten berücksichtigt werden. Dies wird ermöglicht durch die Anwendung kontinuierlicher Shegalkin-Polynome, die Boole'sche Funktionen repräsentieren können.
Self-Reports of Psychosocial Functioning among Children and Young Adults with Cleft Lip and Palate
Authors: Hunt Orlagh , Burden Donald , Hepper Peter , Stevenson Mike , Johnston Chris 
Published: November 2005

Objective: A cross-sectional study was employed to determine the psychosocial effects of cleft lip and/or palate among children and young adults, compared with a control group of children and young adults without cleft lip and palate. Participants: The study comprised 160 children and young adults with cleft lip and/or palate and 113 children and young adults without cleft lip and/or palate. All participants were between 8 and 21 years of age. Outcome measures: Psychological functioning (anxiety, self-esteem, depression, and behavioral problems) was assessed using validated psychological questionnaires. Happiness with facial appearance was rated using a visual analog scale. Social functioning, including experience of teasing/bullying and satisfaction with speech, was assessed using a semistructured interview. Results: Participants with cleft lip and/or palate reported greater behavioral problems (p < .001) and more symptoms of depression (p < .01); they were teased more often (p < .001) and were less happy with their facial appearance (p < .01) and speech (p < .001), compared with controls. There were no significant difference between subjects with cleft lip and/or palate and subjects without cleft lip and/or palate in terms of anxiety (p > .05) or self-esteem (p > .05). Having been teased was a significant predictor of poor psychological functioning, more so than having a cleft lip and/or palate per se (p < .001). Conclusions: Teasing was greater among participants who had cleft lip and/ or palate and it was a significant predictor of poorer psychosocial functioning. Children and young adults with cleft lip and/or palate require psychological assessment, specifically focusing on their experience of teasing, as part of their routine cleft care.
Gender differences in the pharmacokinetics of DA‐6034, a derivative of flavonoids, in rats
Authors: Yang Si H. , Bae Soo K. , Kwon Jong W. , Yoo Moohi , Lee Myung G. 
Published: November 2005

AbstractGender differences in the pharmacokinetics of DA‐6034 were evaluated after intravenous and oral administration at a dose of 50 mg/kg to male and female Sprague–Dawley rats. After intravenous administration to male rats, although the total area under the plasma concentration–time curve from time zero to time infinity of DA‐6034 was not significantly different between male and female rats, the plasma concentrations of DA‐6034 were lower from 30 min to 480 min, the mean residence time was significantly shorter (6.28 versus 12.2 min), the percentage of intravenous dose of DA‐6034 excreted in 24h urine as unchanged drug was significantly greater (14.4% versus 10.5% of intravenous dose). After oral administration, the pharmacokinetic parameters of DA‐6034 were not significantly different between male and female rats. Copyright © 2005 John Wiley & Sons, Ltd.
Influence of secondary reactions on the synthetic efficiency of DHAP‐aldolases
Authors: Suau Trinitat , Álvaro Gregorio , Benaiges M. Dolors , López‐Santín Josep 
Published: November 2005

AbstractThe effect of secondary reactions on DHAP‐dependent aldolase stereoselective synthesis yields is reported. The fuculose‐1‐phosphate aldolase catalyzed synthesis between DHAP and Cbz‐S‐alaninal has been chosen as case study. It has been demonstrated that DHAP is not only chemically degraded in the reaction medium, but also enzymatically. The last reaction has been shown to take place when type II aldolases are used as biocatalysts. In order to minimize the effect of non‐desired reactions, temperature reduction has been shown to be favorable, and operation at 4°C has been chosen as appropriate. On the other hand, the fed‐batch addition of DHAP also increased the synthesis yields and, combined with low temperature, led to almost quantitative conversion. © 2005 Wiley Periodicals, Inc.
Design and performance of a 24‐station high throughput microbioreactor
Authors: Harms Peter , Kostov Yordan , French Joseph A. , Soliman Mohammed , Anjanappa M. , Ram Arun , Rao Govind 
Published: November 2005

AbstractTwo prototype 24‐unit microbioreactors are presented and reviewed for their relative merits. The first used a standard 24‐well plate as the template, while the second consisted of 24‐discrete units. Both systems used non‐invasive optical sensors to monitor pH and dissolved oxygen. The systems were used to cultivate Escherichia coli. Both designs had their merits and the results obtained are presented. In addition, dissolved oxygen control was demonstrated at the milliliter scale and 24 simultaneously monitored fermentations were successfully carried out. These results demonstrated high quality high throughput bioprocessing and provide important insights into operational parameters at small scale. © 2005 Wiley Periodicals, Inc.
Ir‐Catalysed Asymmetric Hydrogenation: Ligands, Substrates and Mechanism
Authors: Källström Klas , Munslow Ian , Andersson Pher G. 
Published: November 2005

AbstractRelatively air and moisture tolerant cationic iridium complexes, with chiral non‐racemic N,P‐ligands and weakly coordinating counter ions, are efficient catalysts in the asymmetric hydrogenation of olefins. Unfunctionalised olefins are particularly difficult substrates because, in general, a polar group adjacent to the alkene bond is required for high catalytic activity and enantioselectivity. The applicability towards a variety of substrates and choice of ligands reported thus far in the literature, as well as the mechanism, selectivity issues and the importance of the anion are also discussed.
Ruthenium‐Cluster‐Mediated Activation of All Bonds of a Methyl Group of 6,6′‐Dimethyl‐2,2′‐bipyridine and 2,9‐Dimethyl‐1,10‐phenanthroline: Transformation of the Latter into a 2‐Alkenyl‐9‐methyl‐1,10‐phenanthroline Ligand
Authors: Cabeza Javier A. , del Río Ignacio , Martínez‐Méndez Lorena , Miguel Daniel 
Published: November 2005

AbstractThe treatment of [Ru3(CO)12] with 6,6′‐dimethyl‐2,2′‐bipyridine (Me2bipy) or 2,9‐dimethyl‐1,10‐phenanthroline (Me2phen) in THF at reflux temperature gives the trinuclear dihydride complexes [Ru3(μ‐H)2(μ3‐L1)(CO)8] (L1=HCbipyMe 1 a, HCphenMe 1 b), which result from the activation of two CH bonds of a methyl group. The hexa‐, hepta‐, and pentanuclear derivatives [Ru6(μ3‐H)(μ5‐L2)(μ‐CO)3(CO)13] (L2=CbipyMe 2 a, CphenMe 2 b), [Ru7(μ3‐H)(μ5‐L2)(μ‐CO)2(CO)16] (L2=CbipyMe 3 a, CphenMe 3 b), and [Ru5(μ‐H)(μ5‐C)(μ‐L3)(CO)13] (L3=bipyMe 4 a, phenMe 4 b) can also be obtained by treating 1 a and 1 b with [Ru3(CO)12]. Compounds 2 a and 2 b have a basal edge‐bridged square‐pyramidal metallic skeleton with a carbyne‐type C atom capping the four Ru atoms of the pyramid base. The structures of 3 a and 3 b are similar to those of 2 a and 2 b, respectively, but an additional Ru atom now caps a triangular face of the square‐pyramidal fragment of the metallic skeleton. The most interesting feature of 2 a, 2 b, 3 a, and 3 b is that their carbyne‐type C atoms were originally bound to three hydrogen atoms in Me2bipy or Me2phen and, therefore, they arise from the unprecedented activation of all three CH bonds of C‐bound methyl groups. The pentanuclear compounds 4 a and 4 b contain a carbide ligand surrounded by five Ru atoms in a distorted trigonal‐bipyramidal environment. They are the products of a series of processes that includes the activation of all bonds (three CH and one CC) of organic methyl groups, and are the first examples of complexes having carbide ligands that arise from C‐bonded methyl groups. The alkenyl derivatives [Ru5(μ5‐C)(μ‐p‐MeC6H4CHCHphenMe)(CO)13] (5 b), [Ru5(μ‐H)(μ5‐C)(μ‐p‐MeC6H4CHCHphenMe)(p‐tolC2)(CO)12] (6 b), and [Ru5(μ‐H)(μ5‐C)(μ‐PhCHCHphenMe)(PhC2)(CO)12] (7 b) have been obtained by treating 4 b with p‐tolyl‐ and phenylacetylene, respectively. Their heterocyclic ligands contain an alkenyl fragment in the position that was originally occupied by a methyl group. Therefore, these complexes are the result of the formal substitution of an alkenyl group for a methyl group of 2,9‐dimethyl‐1,10‐ phenanthroline.
Nucleic Acid Intercalators and Avidin Probes Derived from Luminescent Cyclometalated Iridium(III)–Dipyridoquinoxaline and –Dipyridophenazine Complexes
Authors: Lo Kenneth Kam‐Wing , Chung Chi‐Keung , Zhu Nianyong 
Published: November 2005

AbstractSix luminescent cyclometalated iridium(III)–dipyridoquinoxaline and –dipyridophenazine complexes [Ir(ppy)2(N‐N)](PF6) (Hppy=2‐phenylpyridine; N‐N=dipyrido[3,2‐f:2′,3′‐h]quinoxaline, dpq (1); 2‐n‐butylamidodipyrido[3,2‐f:2′,3′‐h]quinoxaline, dpqa (2); 2‐((2‐biotinamido)ethyl)amidodipyrido[3,2‐f:2′,3′‐h]quinoxaline, dpqB (3); dipyrido[3,2‐a:2′,3′‐c]phenazine, dppz (4); benzo[i]dipyrido[3,2‐a:2′,3′‐c]phenazine, dppn (5); 11‐((2‐biotinamido)ethyl)amidodipyrido[3,2‐a:2′,3′‐c]phenazine, dppzB (6)) have been designed as luminescent intercalators for DNA and probes for avidin. The structure of complex 4 has been studied by X‐ray crystallography. The photophysical and electrochemical properties of the complexes have also been investigated. The binding of these complexes to double‐stranded calf thymus DNA and synthetic double‐stranded oligonucleotides poly(dA)⋅poly(dT) and poly(dG)⋅poly(dC) has been investigated by spectroscopic titrations. The interactions between the two biotin‐containing complexes and avidin have been studied by 4′‐hydroxyazobenzene‐2‐carboxylic acid (HABA) assays and emission titrations.
A New Polymorph of FeAlO3 at High Pressure.
Authors: Nagai Takaya , Hamane Daisuke , Devi P. Sujatha , Miyajima Nobuyoshi , Yagi Takehiko , Yamanaka Takamitsu , Fujino Kiyoshi 
Published: November 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis of Ferromagnetic CsCuCr Prussian Blue Analogue with a Tetragonal Structure.
Authors: Kosaka Wataru , Ishihara Tohru , Yashiro Hisashi , Taniguchi Yayoi , Hashimoto Kazuhito , Ohkoshi Shin‐ichi 
Published: November 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Facile Synthesis of α,β‐Acetylenic Ketones and 2,5‐Disubstituted Furans: Consecutive Activation of Triple and Double Bond with ZnBr2 Toward the Synthesis of Furan Ring.
Authors: Lee Ka Young , Lee Mi Jung , Kim Jae Nyoung 
Published: November 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
A Reaction for sp3—sp3 C—C Bond Formation via Cooperation of Lewis Acid‐Promoted/Rh‐Catalyzed C—H Bond Activation.
Authors: Shi Lei , Tu Yong‐Qiang , Wang Min , Zhang Fu‐Min , Fan Chun‐An , Zhao Yu‐Ming , Xia Wu‐Jiong 
Published: November 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Highly Regioselective Lipase‐Catalyzed Acetylation and Hydrolysis of Acyclic α,α′‐Alkenediols and Their Diacetates.
Authors: Hisano Takaya , Onodera Kotoko , Toyabe Yasuhiro , Mase Nobuyuki , Yoda Hidemi , Takabe Kunihiko 
Published: November 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
A Baylis—Hillman/Ozonolysis Route Towards (.+‐.) 4,5‐Dihydroxy‐2,3‐pentanedione (DPD) and Analogues.
Authors: Frezza Marine , Soulere Laurent , Queneau Yves , Doutheau Alain 
Published: November 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Efficient Two‐Step Synthesis of 3‐Halo‐3‐enals or 2‐Halo‐2‐alkenyl Ketones from Propargylic Bromides via a Unique Cationic 1,2‐Aryl or Proton Shift in Electrophilic Addition Reaction of 2,3‐Allenols with X+.
Authors: Fu Chunling , Li Jing , Ma Shengming 
Published: November 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis of β‐Amino Esters by Regioselective Amination of Allyl Bromides with Aryl and Alkyl Amines.
Authors: Chen Hung‐Yang , Patkar Laxmikant N. , Ueng Shau‐Hua , Lin Chun‐Cheng , Lee Adam Shih‐Yuan 
Published: November 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.