bluuebunny/crossref_metadata_2025_split huggingface dataset:
Arterial spin labeled perfusion MRI for the assessment of radiation-treated meningiomas
Authors: Manning Paul , Srinivas Shanmukha , Bolar Divya S. , Rajaratnam Matthew K. , Piccioni David E. , McDonald Carrie R. , Hattangadi-Gluth Jona A. , Farid Nikdokht 
Published: March 2024

PurposeConventional contrast-enhanced MRI is currently the primary imaging technique used to evaluate radiation treatment response in meningiomas. However, newer perfusion-weighted MRI techniques, such as 3D pseudocontinuous arterial spin labeling (3D pCASL) MRI, capture physiologic information beyond the structural information provided by conventional MRI and may provide additional complementary treatment response information. The purpose of this study is to assess 3D pCASL for the evaluation of radiation-treated meningiomas.MethodsTwenty patients with meningioma treated with surgical resection followed by radiation, or by radiation alone, were included in this retrospective single-institution study. Patients were evaluated with 3D pCASL and conventional contrast-enhanced MRI before and after radiation (median follow up 6.5 months). Maximum pre- and post-radiation ASL normalized cerebral blood flow (ASL-nCBF) was measured within each meningioma and radiation-treated meningioma (or residual resected and radiated meningioma), and the contrast-enhancing area was measured for each meningioma. Wilcoxon signed-rank tests were used to compare pre- and post-radiation ASL-nCBF and pre- and post-radiation area.ResultsAll treated meningiomas demonstrated decreased ASL-nCBF following radiation (p &lt; 0.001). Meningioma contrast-enhancing area also decreased after radiation (p = 0.008) but only for approximately half of the meningiomas (9), while half (10) remained stable. A larger effect size (Wilcoxon signed-rank effect size) was seen for ASL-nCBF measurements (r = 0.877) compared to contrast-enhanced area measurements (r = 0.597).ConclusionsASL perfusion may provide complementary treatment response information in radiation-treated meningiomas. This complementary information could aid clinical decision-making and provide an additional endpoint for clinical trials.
Developing outdoor spaces for work and study—an explorative place-making process
Authors: Jansson Märit , Mårtensson Fredrika , Vogel Nina 
Published: March 2024

IntroductionThe development of outdoor spaces for work and study is part of a larger transition toward sustainable communities, which can take advantage of more flexible ways of organizing everyday life. Governance processes supported by physical spatial changes have the potential to bring together various actors and experts for local development. The aim of this study was to explore the possibilities of developing outdoor spaces for work and study in a collaborative process.MethodsThe study involved an upper secondary school, a local government administration, local businesses and research. The process took place in a South-Swedish small town and included developing outdoor areas for tasks traditionally carried out indoors, participatory workshops and meetings followed up through questionnaires and interviews.ResultsOverall, the introduction of outdoor places was positively evaluated, but engagement varied across actors and over time, and a number of obstacles and challenges in the process were identified.DiscussionThe study showed how vital it is to anchor ideas for place-making locally and having key persons in leading positions with allocated time to support the process. It also indicates how decisive spatial changes can be and how important it is that any physical intervention becomes an integrated part of a wider local process in order to make an imprint on local life and pedagogical practice.
Retrospective analysis of the incidence and outcome of late acute and chronic graft-versus-host disease—an analysis from transplant centers across Europe
Authors: Langer Ronja , Lelas Antonela , Rittenschober Michael , Piekarska Agnieszka , Sadowska-Klasa Alicja , Sabol Ivan , Desnica Lana , Greinix Hildegard , Dickinson Anne , Inngjerdingen Marit , Lawitschka Anita , Vrhovac Radovan , Pulanic Drazen , Güneş Sibel , Klein Stefan , Moritz Middeke Jan , Grube Matthias , Edinger Matthias , Herr Wolfgang , Wolff Daniel 
Published: March 2024

IntroductionChronic graft-versus-host disease (cGvHD) is a serious late complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT).MethodsThis multicenter analysis determined the cumulative incidence (CI) of cGvHD and late acute GvHD (laGvHD) and its impact on transplantation-related mortality (TRM), relapse (R), and overall survival (OS) in 317 patients [296 adults, 21 pediatrics (&lt;12 years of age)] who underwent their first allo-HSCT in 2017.ResultsThe CI of laGvHD was 10.5% in adults and 4.8% in pediatrics, and the CI of cGvHD was 43.0% in all adult transplant patients and 50.2% in the adult at-risk cohort at the study end. The onset of cGvHD was de novo in 42.0% of patients, quiescent in 52.1%, and progressive in 5.9%. In adults, prophylactic use of antithymocyte globulin or posttransplant cyclophosphamide was associated with a significantly lower incidence of cGvHD (28.7%) vs. standard prophylaxis with calcineurin inhibitors (30.6%) and methotrexate/mycophenolate mofetil (58.4%) (all p &lt; 0.01). TRM was significantly higher in patients with aGvHD (31.8%) vs. cGvHD (12.6%) and no GvHD (6.3%) (all p = 0.0001). OS in the adult at-risk cohort was significantly higher in patients with cGvHD (78.9%) vs. without (66.2%; p = 0.0022; HR 0.48) due to a significantly lower relapse rate (cGvHD: 14.5%; without cGvHD: 27.2%; p = 0.00016, HR 0.41). OS was also significantly higher in patients with mild (80.0%) and moderate (79.2%) cGvHD vs. without cGvHD (66.2%), excluding severe cGvHD (72.7%) (all p = 0.0214).DiscussionThe negative impact of severe cGvHD on OS suggests a focus on prevention of severe forms is warranted to improve survival and quality of life.
Green synthesis of silver and iron nano composites using aqueous extract of zanthoxylum armatum seeds and their application for removal of acid black 234 dye
Authors: Bashir Nadia , Gulzar Saba , Shad Salma 
Published: March 2024

Green nanotechnology has gained attraction in recent years due to the growing awareness of the environmental and health risks associated with traditional methods of nanomaterial synthesis. In the present study, nanocomposite (NCs) of silver and Iron were prepared using Zanthoxylum Armatum seeds aqueous extract which acts as a reducing, stabilizing, and capping agent. The synthesized NCs were characterized using UV/Vis Spectroscopy, powder X-ray diffraction (XRD), Scanning Electron Microscopy (SEM), and EDX. The UV/Vis spectroscopy analysis of the NCs revealed the presence of a surface plasmonic resonance band occurring at 420 nm. Examination of the NCs through SEM demonstrated that they exhibited a nearly spherical morphology, with an average particle diameter measuring 54.8 nm. The crystalline nature of these NCs was verified through X-ray diffraction (XRD), and the calculation of crystallite size using the Scherrer-Debye equation yielded a value of 12.6 nm. The adsorption ability of newly synthesized nanocomposites was investigated against Acid Black 234 Dye. The results showed that a 0.5 g of NCs dose at pH 4 removed 99.3% of 10 mg/L of Acid Black 234 Dye within 60 min. Based on the findings of this research, it can be inferred that the that Ag-Fe NCs synthesized from Zanthoxylum Armatum seeds aqueous extract hold significant potential for addressing environmental pollution caused by Acid Black 234 Dye. The NCs were used as adsorbent for the removal of Acid Black 234 dye from the wastewater sample and showed 98% removal of dye from the commercial sample within 60 min. In this context, the research highlights that the environmentally friendly synthesis of Ag-Fe nanocrystals (Ag-Fe NCs) using Zanthoxylum Armatum as a mediator offers an efficient and cost-effective solution for mitigating environmental pollution.
Descriptive Anatomy of the Porcine Ventral Abdominal Wall as a Basis for Training Ventral Hernia Repair Techniques
Authors: Vierstraete Maaike , Van Der Vekens Nicky , Beckers Roel , Renard Yohann , Muysoms Filip 
Published: March 2024

Background: In recent times there has been a surge in innovative techniques concerning complex abdominal wall surgery. The availability of simulation models for comprehensive training and skill set development remains limited.Methods: Cadaveric dissections of the porcine abdominal wall were conducted to assess the suitability of anesthetized porcine models for training in both minimally invasive and open surgical procedures.Results: The panniculus carnosus, a typical muscular layer in mammals, is the outermost layer covering the anterolateral abdominal wall. Beneath it, there are four main pairs of abdominal wall muscles, mirroring the human anatomy. The rectus abdominis muscle runs straight along the linea alba and is surrounded by the rectus sheath, which is formed by the fusion of the lateral abdominal wall muscles and differs along the different regions of abdominal wall. The orientation of the muscle fibers in the lateral abdominal wall muscles, i.e., musculus obliquus externus, internus and transversus, is comparable to human anatomy. Although the transition lines between their muscular and aponeurotic part differ to some extent. Relevant for the adoption of surgical techniques, the transversus abdominis muscle is well-developed and resembles a bell curve shape as it transitions from its muscular to aponeurotic part.Conclusion: Despite minor differences in abdominal wall anatomy between pigs and humans, the porcine model provides a high level of fidelity in terms of both anatomical features and the development of skill sets relevant to hernia surgery.
IMPACT OF STATE SUPPORT ON THE DEVELOPMENT OF DAIRY CATTLE FARMING IN THE IN THE NON-BLACK EARTH REGION OF RUSSIA
Authors: СУРОВЦЕВ В.Н. 
Published: March 2024

Проведена оценка влияния размера и структуры государственной поддержки молочного скотоводства за период 2016—2021 гг. на основные производственные результаты в молочном скотоводстве в 9 регионах Нечерноземной зоны, расположенных в Северо-Западном и Центральном федеральных округах. Сравнительный анализ размеров господдержки и производственных показателей регионов Нечерноземья и Воронежской области — одного из лидеров молочного животноводства в Черноземной зоне выявил углубление диспропорций в распределении этой помощи между регионами, что усиливает межрегиональные диспропорции в развитии отрасли. Определено, что одной из основных причин подобных различий является несовершенство системы государственной поддержки отрасли, направления и формы которой преимущественно ориентированы на реализацию крупных инвестиционных проектов, эффективный размер которых в большинстве регионов Нечерноземья ограничен объективными агроклиматическими условиями. Обоснованы предложения по совершенствованию направлений и форм поддержки государством молочного скотоводства с целью формирования адаптивного производства, реализации абсолютных и сравнительных преимуществ в производстве молока в Нечерноземной зоне России на основе цифровой трансформации.
The impact of the size and structure of state support for dairy cattle breeding for the period 2016-2021 on the main production results in dairy cattle farming in nine regions of the Non-black earth region of Russia located in the North-Western and Central Federal Districts was assessed. A comparative analysis of the amount of state support and the production indicators of the regions of the Non-black earth region and the Voronezh region, one of the leaders of dairy farming in the Chernozem region, revealed a deepening of the disproportions in the distribution of state support between the regions, which strengthens interregional imbalances in the development of dairy farming. It is determined that one of the main reasons for such imbalances is the imperfection of the system of state support for the agricultural sector, the directions and forms of which are mainly focused on the implementation of large investment projects. However, the implementation of the scale effect in dairy farming in most regions of the Non-black earth region is limited by objective agro-climatic conditions. The proposals for improving the directions and forms of state support for dairy cattle breeding are substantiated in order to form adaptive production, realize the absolute and comparative advantages of milk production in Non-Black Earth region of Russia through digital transformation.
Chloramdinone Acetate: Balance of Contraceptive and Therapeutic Effects in Adolescence and Early Reproductive Age
Authors: Иванишкина-Кудина О. Л. 
Published: March 2024

Распространенность гиперандрогении на фоне нарушений менструального цикла, дисменореи среди женщин молодого возраста и подростков крайне высока. Своевременная диагностика позволяет выбрать обоснованную патогенетическую терапию, которая поможет совместить высокую контрацептивную эффективность с одновременно максимально широким использованием лечебных эффектов прогестеронового компонента контрацептивных препаратов и при этом снизить нежелательные медикаментозные и гормональные нагрузки при длительной терапии заболевания. В проведенном нами исследовании установлены высокий терапевтический и контрацептивный эффект, достоверная коррекция клинико-лабораторных проявлений эндокринопатий и гиперандрогенных состояний у девочек-подростков и молодых женщин при назначении препарата Белара, содержащего 2 мг хлормадинона ацетата и 30 мкг этинилэстрадиола.
The prevalence of hyperandrogenism against the background of menstrual disorders, dysmenorrhea among young women and adolescents is extremely high. Timely diagnosis allows you to choose a reasonable pathogenetic therapy that will allow you to combine high contraceptive efficacy and at the same time make the most of the therapeutic effects of the progesterone component of contraceptive drugs and at the same time reduce unwanted drug and hormonal loads during long-term therapy of the disease. Our study established a high therapeutic and contraceptive effect, a reliable correction of clinical and laboratory manifestations of endocrinopathies and hyperandrogenic conditions in adolescent girls and young women when prescribing the drug Belara containing 2 mg of chloramdinone acetate and 30 mcg of ethinyl estradiol.
Interrelation Between Psychoemotional State of Women and the Results of In Vitro Fertilization
Authors: Исмайлова М.К. , Курбанова Дж.Ф. 
Published: March 2024

Цель. Оценка психоэмоционального статуса женщин, прошедших экстракорпоральное оплодотворение (ЭКО), в зависимости от успешности процедуры. Материалы и методы. Были обследованы 311 женщин с бесплодием, обратившихся в Центральную клинику города Баку для прохождения процедуры ЭКО. Все пациенты были разделены на 2 группы: группа А – 145 женщин, у которых беременность в результате ЭКО наступила, и группа В – 166 женщин с ненаступившей беременностью. Всем пациентам была проведена оценка психоэмоционального статуса с помощью анкеты Спилбергера и Бека. В качестве метода экспресс-диагностики уровня стресса использовалась шкала психологического стресса Ридера. Различия считались достоверными при р<0,05. Результаты и обсуждение. Статистически значимых различий между женщинами исследуемых групп в частоте и характере проявлений психоэмоциональных нарушений выявлено не было. Отмечается тенденция к повышению частоты тревожного, тревожно-депрессивного и депрессивного типов психики в группе В и невротического и нормального типов в группе А. У женщин с отрицательным исходом ЭКО значительно чаще зафиксирован высокий уровень стресса – 45,2% в сравнении с женщинами с положительным исходом ЭКО, где частота его равнялся 9,0% (р<0,01). Заключение. Проведенные исследования показали важное значение стрессового фактора в лечении бесплодия в программе вспомогательных технологий, что требует комплексного подхода с применением соответствующей коррекции пациентов до и при проведении экстракорпорального оплодотворения.
The purpose. To assess the psycho-emotional status of women who underwent in vitro fertilization (IVF) depending on the success of the procedure. Materials and methods. 311 women with infertility who applied to the Central Clinic of Baku to undergo the IVF procedure were examined. All patients were divided into 2 groups: group A – 145 women who became pregnant, and group B – 166 women who did not become pregnant. All patients underwent an assessment of the psycho-emotional status of women using the Spielberg and Beck questionnaire. The Reader Psychological Stress Scale was used as a method for express diagnostics of stress levels. Differences were considered significant at p<0.05. Results and discussion. There were no statistically significant differences between the women of the study groups in the frequency and nature of manifestations of psycho- emotional disorders. There is a tendency to increase the frequency of anxious, anxious- depressive and depressive mental types in group B and neurotic and normal types in group A. Women with a negative IVF outcome were significantly more likely to have a high level of stress (45.2%) compared to women with a positive outcome IVF, where its frequency was 9.0% (p<0.01). Conclusion. Thus, the studies have shown the importance of the stress factor in the treatment of infertility in the assisted technology program, which requires an integrated approach using appropriate correction of patients before and during in vitro fertilization.
El final de Bin Laden
Authors: Ilivitzky Matías 
Published: March 2024

Este trabajo busca comprender cómo la operación que finalizó con la vida de Osama Bin Laden, creador de la red terrorista al-Qaeda, puede ser entendida a partir de las razones utilizadas por Hannah Arendt en su obra “Eichmann en Jerusalén” para abordar las problemáticas ligadas al secuestro de Adolf Eichmann en Argentina en 1960, efectuado por el servicio secreto israelí. Sosteniendo que esta operación era legítima debido a que el país sudamericano probablemente nunca habría accedido a su extraditación, la autora también señala que su ejecución fue un castigo justo debido a que Eichmann era un hostis humani generis, es decir, un enemigo de la humanidad.
Las similitudes entre ambos casos aquí abordados permiten realizar este tipo de comparación teórica. El 2 de mayo de 2011 un grupo de fuerzas especiales estadounidenses ejecuta a Bin Laden en un complejo residencial en Pakistán. Esta operación encubierta tuvo lugar en el marco de una gran tensión y desconfianza entre ambas naciones, al igual que las que existieran entre Israel y Argentina en 1960. Los nexos entre ambas situaciones permiten en consecuencia indagar sobre cómo Hannah Arendt podría haber entendido lo acontecido en 2011 a la luz de su parecer sobre lo sucedido cincuenta años antes.
Las medidas de protección para víctimas de género durante el aislamiento por Covid-19
Authors: Arias-Mendoza Janeth Alexandra , Merizalde-Avilés María Lorena , Romero-Fernández Ariel José , Saquicela-Rodas Iván 
Published: March 2024

El objetivo general de la investigación fue analizar jurídicamente las medidas de protección para víctimas de género durante el aislamiento por Covid-19. El método empleado en la investigación, se basó en el enfoque cualitativo, manejando la recolección y análisis de una tipología documental-bibliográfica. La técnica de investigación aplicada fue la entrevista. Generándose un proceso analítico–reflexivo, contribuyendo a la generación de la extensión del estado del arte. Se concluye que, la violencia contra la mujer y miembros del núcleo familiar ha incrementado considerablemente durante el estado de excepción a consecuencia de la emergencia sanitaria Covid-19; evidenciándose índices preocupantes con mayor presencia en las zonas rurales del país, por lo que se requiere de parte del Estado ecuatoriano implementar una política pública de acción coordinada, efectiva y eficiente a fin de lograr una disminución del índice delictivo en materia de violencia de género y violencia intrafamiliar.
Pengembangan Bahan Ajar Digital Berbasis Software 3D Pageflip Professional pada Materi Pokok Larutan Elektrolit dan Non Elektrolit untuk SMA/MA Kelas X
Authors: Syamsudin Fitria K , Bandu Sudirman , Lalang Arvinda C. , Lestarani Dewi , Lantik Vinsensius 
Published: March 2024

Ilmu kimia tidak hanya sekedar memecahkan soal-soal tetapi kita harus mempelajari deskripsi seperti fakta kimia, aturan-aturan kimia dan bahan atau materi yang dipelajari dalam ilmu kimia sangat banyak. Banyaknya bahan yang harus dipelajari sehingga tidak sedikitnya siswa yang tidak suka dengan pelajaran kimia. Akibatnya hasil belajar siswa banyak yang tidak tuntas. Salah satu upaya untuk mengatasi hal ini adalah dengan mengembangkan bahan ajar yang menarik. Maka penelitian ini bertujuan untuk mengetahui wujud hasil pengembangan dan kelayakan bahan ajar digital menggunakan 3D Pageflip Profesional. Penelitian pengembangan ini menggunakan model ADDIE. Hasil penelitian diperoleh wujud pengembangan bahan ajar digital menggunakan 3D Pageflip Profesional pada materi larutan elektrolit dan non elektrolit yaitu terdiri dari cover, pengantar, petunjuk modul, tampilan utama (pendahuluan, materi, rangkuman materi, soal evaluasi), dan halaman akhir yang memuat nama pengembang. Produk bahan ajar ini juga memuat gambar, dan video pendukung pembelajaran yang membantu siswa dalam memahami materi larutan elektrolit dan non elektrolit serta video tutorial pemakaian bahan ajar digital. Sementara hasil uji kelayakan penilaian ahli materi memiliki kategori baik dengan presentase keidealan 79,84% dan penilaian ahli media memiliki kategori sangat baik degan presentase yaitu 95,29. Hasil uji coba dalam hal uji respon siswa memiliki kategori sangat baik dengan persentase keidealan masing-masing pada uji coba kelompok kecil sebesar 97,36 dan pada uji coba kelompok besar sebesar 97,21. Berdasarkan hasil penilaian ahli materi, ahli media dan uji respon siswa yang terdiri dari uji coba kelompok kecil dan kelompok besar yang dilakukan tersebut maka dapat disimpulkan bahwa bahan ajar ini layak di gunakan dalam pembelajaran.
Perancangan Bahan Ajar Elektronik Berbasis Android Guna Meningkatkan Literasi Peserta Didik
Authors: Sudirman Sudirman , Maran Bibiana Rume , Christianto Heru , Parera Lolita A. M. 
Published: March 2024

Research has been carried out with the title Designing Android-Based Electronic Teaching Materials to Improve Student Literacy. This study aims to determine: (1) the form of android-based electronic teaching materials on chemical equilibrium materials, (2) the level of validity of android-based electronic teaching materials on chemical equilibrium materials, and (3) student responses to the development of android-based electronic teaching materials on chemical equilibrium material. The development model used is the ADDIE model. The android-based electronic teaching material product that has been developed is in .apk format with a capacity of 74.6 megabytes named “Chemical equilibrium”. The results of the assessment of material and media experts on the level of validity of these electronic teaching materials have a very valid category with the percentage of overall validity being 96.19% and 90.20%, respectively. Meanwhile, the response of students to this electronic teaching material when the trial was carried out on average showed a very good response by getting the overall percentage was 97.78% in the small group trial and 96.33% in the large group trial. Thus, this android-based electronic teaching material on chemical equilibrium material is suitable for use in chemistry learnin activities as a source of independent learning and learning media.
Keywords: Electronic Teaching Materials, Android, ISpring Suite 10, Website 2 APK Builder, Chemical Equilibrium