bluuebunny/crossref_metadata_2025_split huggingface dataset:
WITHDRAWN: Performance evaluation of an automated Terminal Aerodrome Forecast verification tool over Indian Meteorological Watch Offices
Authors: Singh Neeti , Mishra Anoop Kumar , Tomar C. S. , Kumar Gajendra 
Published: March 2024

Abstract

This paper focuses on performance evaluation of an automated Aviation Forecast Verification System (AFVS) over Indian Meteorological Watch Offices, verification has been carried out for TAF as per ICAO (International Civil Aviation Organization) guidelines for four MWO (Meteorological Watch Office) stations viz. Delhi, Chennai, Mumbai, and Kolkata. This automated tool is customized as per International Civil Aviation Organization (ICAO) guidelines. The performance evaluation of the tool has been carried out for six meteorological parameters including wind direction, wind speed, visibility, precipitation, cloud amount and cloud height for the years 2017, 2018, 2019, 2020 and 2021 against Meteorological Aerodrome Report (METAR). Validation results with METAR observations show the verification percentage of 93.62%, 99.56%, 99.11%, 83.62%, 67.59%, 54.77% for precipitation, cloud amount, cloud height, wind speed, visibility, and wind direction, respectively. This performance is as per ICAO standard except for wind direction and visibility. Non-compliance of TAF accuracy against ICAO threshold for wind direction and visibility may be attributed to the dynamic nature of these parameters. Furthermore, it has been reported that wind speed, precipitation, cloud amount, and cloud height provide better verification results than ICAO recommended values. Results reported in this study highlights the importance of implementation of an automated verification tool for the efficient verification of TAF for the application in flight management system.
Computational Drug Discovery for Novel Small Molecule Inhibitors Targeting LRRK2 in Parkinson's Disease Treatment
Authors: emmanuel adetobi , oluwamayowa akinsuyi , victoria Oladosu , babtunde shofolu , ogunmola temitope , moses ohi 
Published: March 2024

Abstract
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons in the brain, leading to motor and non-motor symptoms. The development of novel pharmacotherapies targeting specific molecular pathways implicated in PD pathogenesis is crucial for disease management. Leucine-rich repeat kinase 2 (LRRK2) has emerged as a promising therapeutic target due to its involvement in both familial and sporadic forms of PD. In this study, we employed computational drug discovery techniques to identify potential small molecule inhibitors targeting LRRK2 for PD treatment. The binding affinities of virtual test compounds with the LRRK2 drug target were assessed, revealing a range of affinities from − 6.8 to -10.2 kcal/mol. Lead compounds, including Compound 7, 14, and 15, exhibited the highest binding affinities (-10.2, -10.1, and − 10.1 kcal/mol, respectively), surpassing those of standard ligands. Molecular docking analysis elucidated the inhibitory properties of selected lead compounds, with C7, C14, and C15 identified as the most potent LRRK2 inhibitors. These compounds demonstrated favorable interactions with specific amino acid residues within the LRRK2 receptor, indicating their potential therapeutic efficacy. The validation of the docking protocol confirmed the accuracy of the computational methodology employed, ensuring reliable predictions of ligand-receptor interactions. Furthermore, the ADMET profile analysis provided insights into the drug-like characteristics and pharmacokinetic properties of selected lead compounds. Despite variations in lipophilicity, water solubility, and bioavailability scores, most test compounds exhibited moderate to high GI absorption potential and skin permeation values, suggesting their suitability for oral administration and blood-brain barrier penetration. Toxicity profile predictions highlighted potential hepatotoxicity and mutagenicity risks associated with selected lead compounds, emphasizing the importance of further experimental validation and optimization. Overall, this study contributes to the identification and characterization of novel small molecule inhibitors targeting LRRK2 for PD treatment, offering valuable insights into the rational design of potential disease-modifying therapies.
Primary outcomes of robot-assisted mediastinal surgery in the early postoperative period: Its advantage in large mediastinal masses at early stage
Authors: Dong Zheng , Liu Daoquan , Cheng Nitao , Wang Xianguo , Huang Jingyu , Li Changsheng , Liu Jun , Hu Weidong 
Published: March 2024

Abstract

Aims
Current study aims to assess the safety and efficacy of robot-assisted thoracoscopic surgery (RATS) for sizable mediastinal masses with a minimum diameter ≥ 6 cm, compared with video-assisted thoracoscopic surgery (VATS) and open surgery.
Method
This study enrolled 273 patients with non-invasion mediastinal tumors in Zhongnan Hospital, Wuhan University, including 54 patients who underwent RATS, 167 patients who underwent VATS and 52 patients who underwent open surgery. After classifying based on mass size and whether it has invaded or not, we compared their clinical characteristics and perioperative outcomes.
Results
There was no significant difference in age, gender, mass size, myasthenia gravis, mass location, pathological types and presence of invasion (p > 0.05) in three groups. No obvious difference was discovered in the average postoperative length of stay, operation duration, chest tube duration and average postoperative day 1 drainage output between RATS group and VATS group (p > 0.05), while intraoperative blood loss in RATS group was significantly lower than VATS group (p = 0.022). Moreover, the postoperative length of stay, operation duration, chest tube duration and intraoperative blood loss in RATS group were significantly lower than open surgery group (p < 0.001).
Conclusion
RATS is a secure and efficient approach for removing large mediastinal masses at early stage. In comparison with VATS, RATS is associated with lower intraoperative blood loss. Compared with open surgery, RATS is also associated with shorter postoperative length of stay, operation duration, chest tube duration and intraoperative blood loss.
Assessment of crop water requirement and irrigation scheduling for selected crops in the Kohima district, Nagaland, India
Authors: Patle Ghanshyam T. , Panggeng Tome 
Published: March 2024

Abstract

This study was done to examine agricultural water and irrigation schedules for key crops grown in Kohima area of Nagaland, India, which has a humid subtropical climate. Climatic data over 16 years (2006–2021) were used to estimate crop water requirements using CROPWAT 8.0 model. Rice, maize, soybean, potato, cabbage, dry bean, ginger, and naga chili are the most common crops. ET0 was calculated using the FAO Penman–Monteith method and ranged from 1.41 to 3.65 mm/day. The USDA SCS approach calculated effective rainfall. The average annual ETC for rice, maize, ginger, soybean, bean (dry), potato, cabbage, and naga chili were 537.1, 305.7, 342.7, 292.2, 288.1, 364.3, 190.6, and 141 mm, respectively. Rice, maize, ginger, soybean, bean (dry), potato, cabbage, and naga chili require an average of 251.7, 54.9, 26, 73.1, 21.3, 21.9, 121.9, and 14.5 mm of irrigation each year, respectively. The crop irrigation schedules were created with 70% efficiency. The study emphasizes that irrigation must be adjusted to each crop's individual needs, whether through strategic scheduling or modifying net and gross irrigation volumes, to enhance water management and maximize crop production in the region.
Adsorption of the fungicide carbendazim on activated carbon: analysis of isotherms, kinetics, rapid small-scale column tests, and impacts of the presence of organic matter
Authors: Almeida Ian Rocha de , Keller Geovana Eliza Maria , Tavares Lígia Conceição , da Silva Salatiel Wohlmuth , Benetti Antônio Domingues 
Published: March 2024

Abstract

The adsorption of the fungicide carbendazim (CBZ) on granular activated carbon (GAC) made from bovine bone was investigated in deionized water (DW) and DW with the addition of natural organic matter (DWNOM). The study included tests of isotherms, kinetics, and rapid small-scale column tests (RSSCT). The Freundlich model represented better the adsorption of the fungicide in both matrices, while the pseudo-second-order model fitted better in DW. The isotherm and kinetic studies showed the interference of NOM in the adsorption of CBZ through changes in the parameters of the applied models. In RSSCT, the breakthrough time was faster in DWNOM than in DW. Nevertheless, the CBZ concentrations of both matrices were considered statistically similar for most contact times in RSSCT. In the fixed-bed experiments, the organic matter did not cause significant changes in the adsorption of CBZ in GAC. The NOM presence may have improved the efficiency of GAC in adsorbing CBZ in kinetic and RSSCT tests. There is no knowledge of a similar approach to studying the adsorption of CBZ on GAC in Brazil, mainly using fixed-bed studies. In this way, the present work contributes to a better understanding of the adsorption of carbendazim through the methods used.
The Hepatoprotective Effects of Ginsenoside from Ginseng: A Review of
Molecular Mechanisms and Therapeutic Potentials
Authors: Taha Seyed Reza , Fazlollahpour-Naghibi Andarz , Zadeh Mahdieh Shariat , Bagheri Kimia , Youshanlouei Hamed Rahmani , Mosaddeghi-Heris Reza , Hejazian Seyyed Sina , Khalaji Amirreza , Alavi Seyedeh Shaghayegh , Fattahi Payam , Mehrtabar Saba 
Published: March 2024

Abstract:
Treatment of hepatic diseases presents a significant challenge due to their diverse
nature. Ginsenosides, bioactive compounds derived from the root of Panax ginseng and widely
used in traditional Chinese medicine, offer multifaceted protection to various organs in the body.
Their versatile effects, including antioxidant, anti-inflammatory, anti-apoptotic and more, make
them a promising approach for addressing hepatic disorders. This review explores the intricate
molecular mechanisms and properties of ginsenosides in the prevention and treatment of liver
ailments, from mild conditions to severe damage and liver fibrosis. Given the increasing prevalence
of hepatic disorders, this article sheds light on the significant pharmaceutical potential of
ginsenosides in the realm of hepatic disease management.
An Insight into Herbal Interventions for Breast Cancer: A Comprehensive
Review
Authors: Shukla Nishi , Usmani Shazia , Siddiqui Sahabjada , Prakash Om , Wahab Shadma , Khatoon Shabana 
Published: March 2024

Abstract:
New therapies for life-threatening ailments like breast carcinoma are urgently required to
relieve the ever-increasing burden of the mortality associated with it. The very specific feature associated
with life-giving natural products is their lesser toxicity concerning existing strategies viz
chemotherapy or adjuvant modalities. In our review, we have tried to compile the existing data on
exploring herbal extracts and bio-actives through various in vitro and in vivo techniques. An attempt
has been made to accumulate data for a scrupulous literature review retrieved via pertinent keywords
in authentic records. Web of Science, Scopus, and Science Direct. The major keywords included
herbal extract, in vitro, anticancer, and metastasis. A comprehensive exploration unveiled an imperative
role against malignancies of various tissues, but we focussed on breast cancer cell lines. Still,
extensive reports on herbal alternatives and their bio-active mechanism are highly implicated in tapping
their potential as standardized regimens. Scientific evidence, correlations, and proper safety data
may substantiate interventions in cancer therapy.
Clinical Application of Automatic Assessment of Scoliosis Cobb Angle Based on
Deep Learning
Authors: Ni Lixin , Zhang Zhehao , Zou Lulin , Wang Jianhua , Guo Lijun , Qian Wei , Xu Lei , Xu Kaiwei , Zeng Yingqing 
Published: March 2024

Introduction:
A recently developed deep-learning-based automatic evaluation model provides reliable and efficient Cobb angle measurements for scoliosis
diagnosis. However, few studies have explored its clinical application, and external validation is lacking. Therefore, this study aimed to explore the
value of automated assessment models in clinical practice by comparing deep-learning models with manual measurement methods.

Methods:
The 481 spine radiographs from an open-source dataset were divided into training and validation sets, and 119 spine radiographs from a private
dataset were used as the test set. The mean Cobb angle values assessed by three physicians in the hospital's PACS system served as the reference
standard. The results of Seg4Reg, VFLDN, and manual measurement were statistically analyzed. The intra-class correlation coefficients (ICC) and
the Pearson correlation coefficient (PCC) were used to compare their reliability and correlation. The Bland-Altman method was used to compare
their agreement. The Kappa statistic was used to compare the consistency of Cobb angles at different severity levels.

Results:
The mean Cobb angle values measured were 35.89° ± 9.33° with Seg4Reg, 31.54° ± 9.78° with VFLDN, and 32.23° ± 9.28° with manual
measurement. The ICCs for the reliability of Seg4Reg and VFLDN were 0.809 and 0.974, respectively. The PCC and MAD between Seg4Reg and
manual measurements were 0.731 (p<0.001) and 6.51°, while those between VFLDN and manual measurements were 0.952 (p<0.001) and 2.36°.
The Kappa statistic indicated VFLDN (k= 0.686, p< 0.001) was superior to Seg4Reg and manual measurements for Cobb angle severity
classification.

Conclusion:
The deep-learning-based automatic scoliosis Cobb angle assessment model is feasible in clinical practice. Specifically, the keypoint-based VFLDN
is more valuable in actual clinical work with higher accuracy, transparency, and interpretability.
Effects of Intermittent Fasting on Gastrointestinal Health: A Mini Review
Article
Authors: Khayyat Yasir M , Aljahdali Salma M , Alzahrani Shroq H , Jaha Rahaf K , Kalifih Ola A , Malayoo Baraah O 
Published: March 2024

Introduction::
Intermittent fasting (IF) is a popular topic in the medical and fitness
fields because it helps reduce weight, improve metabolic health, and protect against diseases. In
this short review, we summarized some of the current aspects of IF in relation to the gastrointestinal
tract and highlighted the knowledge gap that may outline possible future research in this
field.

Methods::
The PubMed database was used to conduct narrative research of studies related to humans
and mice regarding IF and its effect on five different aspects.

Results::
First, the studies reported conflicting results; some supported the role of IF in promoting
weight loss, while others concluded that the intervention, rather than IF itself, leads to weight
reduction. Second, IF was shown to positively affect secretory immunoglobulin A, cell regeneration,
and the gut microbiome. Third, IF was shown to improve the immune response. Fourth, IF
was shown to promote stem cell-based regeneration; fifth, studies showed that IF has no effect
on gastric or stool pH levels. We also mentioned normal gut motility and the migrating motor
complex.

Conclusion::
In conclusion, these results suggest that IF has a positive effect on these different
aspects, even though there is a lack of human trials, which would be a fruitful area for further
studies.
The Regional Labor Market in the Field of Tourism and the Hotel Industry in the Context of the Transformation of the Russian Economy
Authors: Tomakova I. A. , Fedorova A. R. , Bredikhin V. V. 
Published: March 2024

The relevance. The departure of foreign companies, combined with the growth of domestic demand, has created positive prerequisites for the development of domestic hotel chains and domestic tourism. These objective processes have led to the need to assess the labor market in the tourism and hotel industry in order to identify problems and ways to solve them with the increasing demand of enterprises in this field for qualified specialists. The purpose of the study is to study and analyze the current situation and problems in the labor market in the tourism and hotel industry of the Kursk region. The objectives were to assess the job market in the region, requests and offers from employers, the structure of vacancies and the activity of applicants. Methodology. The research methodology is based on the analysis of statistical information contained in the all-Russian federal database of vacancies and resumes of specialists in the tourism and hotel industry. Results. The data of Russian online recruitment platforms are analyzed and systematized. Based on the results of the analysis of the composition and structure of the labor market of specialists in the hospitality sector, the comparison of supply and demand indicators in it, the analysis of wages in the field under consideration and the dynamics of its change, measures were proposed, the implementation of which will ensure the sustainable development of the industry. Conclusions. Despite some problems and shortcomings in the hospitality sector of the Kursk region, this industry continues to develop and grow. With the growing number of tourists and an increase in the volume of services provided, the labor market in this area is becoming more competitive and attractive for qualified specialists. Regular monitoring of the labor market and analysis of changes in personnel qualification requirements will improve the quality of services provided and meet the growing demand for hospitality workers.
Efficacy of Internet-Based Cognitive Behavioral Therapy for Subthreshold Depression Among Older Adults in Institutional Long-Term Care Settings: Pragmatic Randomized Controlled Trial
Authors: Kong Fanqian , Yu Libo , Hou Yanbin , Zhu Lijie , Zhou Jing , Huang Lingjie , Lv Yueer , Wang Li , Zhang Li , Yang Yiling , Ying Yuchen 
Published: March 2024

Background
Subthreshold depression (sD) is prevalent in older populations in long-term care (LTC) settings, but psychological therapy in LTC settings in China is not readily available. Thus, internet-based cognitive behavioral therapy (ICBT) may be suitable for this population, but research on the efficacy of ICBT for older adults with sD, especially those living in LTC settings, is limited.

Objective
This study aimed to evaluate the efficacy and acceptability of ICBT treatment for sD among LTC residents in China. We also examined whether ICBT is as effective as group-based cognitive behavioral therapy (CBT) for treating sD in this population.

Methods
We conducted a pragmatic randomized controlled trial, which included 18 LTC institutions. A total of 354 participants were randomized to ICBT, group-based CBT, or a waiting list and were followed up for 12 months. The primary outcome was self-reported depressive symptoms on the Center for Epidemiological Studies Depression Scale (CES-D). Secondary outcomes were the scores of the Patient Health Questionnaire–9 (PHQ-9), Generalized Anxiety Disorder 7-Item (GAD-7), and Geriatric Depression Scale (GDS). A mixed-effects model was used to assess the efficacy of ICBT.

Results
The ICBT group showed a significant improvement in self-reported depressive symptoms, which was maintained at the 12-month follow-up (all P<.001). The ICBT group exhibited a significantly larger reduction in the scores of the CES-D (Cohen d=0.07, 95% CI 0.04-0.09; P=.01), PHQ-9 (d=0.30, 95% CI 0.28-0.33; P<.001), GDS (d=0.10, 95% CI 0.08-0.13; P<.001), and GAD-7 (d=0.19, 95% CI 0.17-0.22; P<.001) compared with a waiting list at postintervention. ICBT had significantly stronger effects than CBT on the PHQ-9 and GAD-7 at postintervention (d=0.15, 95% CI 0.13-0.17; P<.001 and d=0.21, 95% CI 0.19-0.23; P<.001, respectively), 6-month follow-up (d=0.18, 95% CI 0.16-0.21; P<.001 and d=0.18, 95% CI 0.15-0.21; P<.001, respectively), and 12-month follow-up (d=0.15, 95% CI 0.11-0.19; P<.001 and d=0.18, 95% CI 0.14-0.21; P<.001, respectively).

Conclusions
ICBT is a relatively effective and acceptable intervention for reducing depressive symptoms among Chinese LTC residents with sD. These findings indicate the usefulness of ICBT application for sD in LTC settings.

Trial Registration
Chinese Clinical Trial Registry ChiCTR2000030697; https://www.chictr.org.cn/showproj.aspx?proj=50781
Adaptive Robust Tracking Control of Robotic Manipulator based on SMC and Fuzzy Control Strategy
Authors: Mary Ali Hussien , Al-Talabi Ahmad , Kara Tolgay , Muneam Dina Saadi , Almuhanna Mohammad Yahya , Mayyahi Laith Awda Kadhim 
Published: March 2024

In recent years, robotic systems have been widely used in different applications, and this has motivated researchers to develop different control methods. A model-free, intelligent, robust control method for a nonlinear robotic manipulator system is proposed in this work. This paper presents a novel solution for the major drawbacks of the sliding mode control scheme, which are chattering. Prior knowledge is needed about the dynamic model of the controlled system and the upper bound of uncertainty. In this paper, a fuzzy-like PD controller with SMC (FLPDSM) is proposed. The fuzzy-like PD controller was designed according to fuzzy rules and membership functions based on the nominal model of the robot manipulator. A robust control term was added to the control signal to compensate for the system uncertainty, and external disturbances are compensated by adding an auxiliary robust term to the SMC control law. Two methods for designing robust control terms are proposed. The first proposed method assumes that the upper bound of system uncertainty is known although it cannot be exactly determined due to external disturbances and uncertainty. Hence, a second method was proposed that assumes this bound to be unknown, and an adaptive gain based on Lyapunov theory was used to derive the adaptation law. The Lyapunov second method was used to ensure the stability of the closed loop system. Performance tests on the proposed methods were implemented through simulation studies for the two-link robotic manipulator, and the test results were compared with the standard SMC to verify the effectiveness of the proposed method. A good trajectory tracking with a high robustness against parameter variations and external disturbances was observed under the presented control scheme.
Susurros del agua: ecos del urbanismo mesoamericano resonando en el presente. El caso de Coatetelco, Morelos y su Diosa-Serpiente
Authors: Bustos Garduño Ma. del Carmen 
Published: March 2024

La espina dorsal de este ensayo está enfocada en el pensamiento de Coatetelco, Morelos a través de la oralidad, por lo que se comienza por evocar la peculiar sonoridad de la palabra susurro. De ahí se sigue hacia la dilucidación de los mitos como narrativas sustentantes de la sabiduría de los pueblos, particularmente en la mitología ginocéntrica ancestral que pervive en la comunidad con el objetivo de situar esta mitopoiesis como las voces generatrices que dieron forma a lo urbano y arquitectónico.
Por último, se realiza una hermenéutica de los mitos coatetelquenses con relación a lo urbano-arquitectónico con el propósito de presentarlos como una base filosófica esperanzadora que pueda aportar nuevos conceptos a la ciudad contemporánea y sus arquitecturas. En especial, se busca fomentar un habitar convivencial imbuido de espiritualidad y erotismo.