bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bowen disease with sebaceous differentiation arising from clonal seborrheic keratosis
Authors: Takayama Eriko , Takai Toshihiro , Fujimoto Masakazu , Yoshioka Akiko 
Published: March 2024

AbstractWe present a rare case of clonal seborrheic keratosis (SK) with focal Bowen disease (BD) (squamous cell carcinoma in situ) accompanied by sebaceous differentiation. An 89‐year‐old woman presented with a pale reddish‐brown plaque on the left buttock. Histopathological examination of the excisional specimen revealed hyperkeratosis, acanthosis, and intraepidermal epithelioma. In some areas of the tumor, we observed proliferation of basaloid keratinocytes within the intraepidermal nests and pseudohorn cysts. This area was diagnosed as clonal SK. However, in other areas, the tumor cells within the intraepidermal nests showed nuclear pleomorphism, abnormal mitoses, dyskeratotic cells, and clumping cells, consistent with BD with a nested/clonal pattern (clonal BD). The SK and BD areas were contiguous with the transitional zone. Some nests within the BD area contained vacuolated cells with bubbly cytoplasm and scalloped nuclei, suggestive of sebaceous differentiation. Therefore, we made the diagnosis of clonal BD with sebaceous differentiation arising from clonal SK. All areas contained intraepidermal nests, which revealed that the lesions were not the result of accidental collision, but that the neoplastic cells in the intraepidermal nests of the SK transformed into BD and underwent sebaceous differentiation.
Taking the Road Less Travelled: How Corpus‐Assisted Discourse Studies Can Enrich Qualitative Explorations of Large Textual Datasets
Authors: Gillings Mathew , Learmonth Mark , Mautner Gerlinde 
Published: March 2024

AbstractHow might interpretivist qualitative researchers tackle large data sets consisting of millions or even billions of words? Corpus‐assisted discourse studies (CADS) is the approach we explore here. Specifically designed for the analysis of voluminous textual data, it offers a recognized empirical approach for making sense of such data. But it does so within an epistemology that understands language to be central in shaping our understanding of the world around us, so that CADS can assist researchers in revealing the social dynamics of the text – including the ideology and power that is latent in many such corpora. Bringing together the training of applied linguists and a management scholar, we discuss the background to CADS and its differences from text‐mining approaches such as topic modelling, which have been more widely used in management studies to date. Focusing on the needs of people who are new to the approach, we then offer a worked example to show CADS’ potential in exploring a management‐related corpus. Our paper concludes with a discussion of the strengths and weaknesses of the approach and its potential for future discursively orientated management research – especially in the context of the rise of ‘big data’.
Exceptionally long‐lasting response to dabrafenib plus trametinib treatment in a patient with lung adenocarcinoma harboring the BRAF V600E mutation with high expression of PD‐L1: A case report
Authors: Inoue Takako , Kunimasa Kei , Tamiya Motohiro , Kawamura Takahisa , Minami Toshiyuki , Nishino Kazumi 
Published: March 2024

AbstractWe present a patient with lung adenocarcinoma showing high PD‐L1 expression and BRAF V600E mutation, who achieved a remarkable long‐term response to the combination therapy of dabrafenib and trametinib (DT treatment) after disease progression on immunotherapy. This case may provide an opportunity for clinicians to consider the order of administration of immunotherapy and molecular targeted therapy for BRAF V600E‐positive lung cancer.
Price support policy and market price dynamics: The case of Indian wheat
Authors: Tripathi Ashutosh K. 
Published: March 2024

AbstractThe study investigates the effect of price support policies on market price distribution and its dynamics in the Indian wheat market. The analysis uses a quantile autoregression model that provides a flexible representation of price dynamics and the 2001–2020 monthly wholesale market price data. The analysis is conducted conditional on the net stock level held in the previous period. The results reveal that the net purchase by the government prevented very low market prices for wheat but resulted in price spikes. It has a price‐enhancing effect as well. The associated moments of price distribution show that public stockholding reduced variation in market price distribution. However, the government's release of stock did not prevent price rises. Findings show that dynamic adjustments tend to be qualitatively different across regimes. Government intervention in the grain market reduced stability through dynamic adjustments in wheat market prices. The results have policy implications for India and other countries in Southeast Asia in the context of the WTO's negotiations on public stockholdings and using public stockholdings as an instrument in addressing price volatility and food shortages.
House dust mite SCIT reduces asthma risk and significantly improves long‐term rhinitis and asthma control—A RWE study
Authors: Jutel Marek , Klimek Ludger , Richter Hartmut , Brüggenjürgen Bernd , Vogelberg Christian 
Published: March 2024

AbstractBackgroundThe German Therapy Allergen Ordinance (TAO) triggered an ongoing upheaval in the market for house dust mite (HDM) allergen immunotherapy (AIT) products. Three HDM subcutaneous AIT (SCIT) products hold approval in Germany and therefore will be available after the scheduled completion of the TAO procedure in 2026. In general, data from clinical trials on the long‐term effectiveness of HDM AIT are rare. We evaluated real‐world data (RWD) in a retrospective, observational cohort study based on a longitudinal claims database including 60% of all German statutory healthcare prescriptions to show the long‐term effectiveness of one of these products in daily life. Aim of this analysis was to provide a per product analysis on effectiveness of mite AIT as it is demanded by international guidelines on AIT.MethodsSubjects between 5 and 70 years receiving their first (index) prescription of SCIT with a native HDM product (SCIT group) between 2009 and 2013 were included. The exactly 3:1 matched control group received prescriptions for only symptomatic AR medication (non‐AIT group); the evaluation period for up to 6 years of follow‐up ended in February 2017. Study endpoints were the progression of allergic rhinitis (AR) and asthma, asthma occurrence and time to the onset of asthma after at least 2 treatment years.ResultsIn total, 892 subjects (608 adults and 284 children/adolescents) were included in the SCIT group and 2676 subjects (1824 adults and 852 children/adolescents) in the non‐AIT group. During the follow‐up period after at least 2 years of SCIT, the number of prescriptions in the SCIT group was reduced by 62.8% (p < .0001) for AR medication and by 42.4% for asthma medication (p = .0003). New‐onset asthma risk was significantly reduced in the SCIT vs non‐AIT group by 27.0% (p = .0212). The asthma‐preventive effect of SCIT occurred 15 months after start of the treatment. In the SCIT group, the time to onset of asthma was prolonged compared to the non‐AIT group (p = .0010).ConclusionIn this first product based RWD analysis on SCIT with a native HDM product, patients aged 5 to 70 years benefited from AIT in the long term in terms of reduced progression of AR and asthma after at least 2 years of treatment. The effects seemed to last for up to 6 years after treatment termination. A significantly reduced risk of asthma onset was observed, starting after 15 months of treatment.
Equity and fairness in the location of public facilities
Authors: Giovanniello Monica Anna , Tonin Simone 
Published: March 2024

AbstractWe analyze the problem of fairly locating two facilities providing a public good in two spatial models: a city line and a network. Each facility is characterized not only by its location but also by its quality. We introduce new notions of envy‐freeness and fairness that can be applied to spatial settings. We show that the tax scheme adopted to finance the public good has a key role in determining the existence of a spatially fair configuration of facilities.
Inflammatory bowel disease (IBD) patients with impaired quality of life on biologic therapy benefit from the support of an IBD nurse specialist: Results of a randomised controlled trial in Germany (IBDBIO‐ASSIST study)
Authors: Bokemeyer Bernd , Plachta‐Danielzik Sandra , Steiner Isa Maria , Pohlschneider Daniela , Urzica Eugen , Hartmann Petra , Zemke Jennifer , Tappe Ulrich , Schreiber Stefan , Steinkat Nadine , Langbrandtner Jana , Hüppe Angelika , Stargardt Tom 
Published: March 2024

SummaryBackgroundIBDBIO‐ASSIST was a randomised controlled trial assessing the efficacy of care provided by IBD nurse specialists in Germany in improving health‐related quality of life (QoL) in IBD patients on biologic therapy.AimTo evaluate patient‐related outcomes and economic consequences associated with integrating IBD nurses into usual care.MethodsWe randomly assigned 1086 patients with IBD on biologic therapy to a control group (CG) receiving usual care or an intervention group (IG) receiving additional care from an IBD nurse specialist. The primary outcome was disease‐specific QoL (sIBDQ) assessed at 6, 12 and 18 months.ResultsAt baseline, patients in both groups were highly satisfied with their treatment situation and had relatively high sIBDQ values (range: 1–7; CG: 5.12; IG: 4.92). In the intention‐to‐treat (ITT) analysis of the overall sample, there was no significant difference in sIBDQ between groups at the assessment time points. However, a per‐protocol analysis of patients with impaired QoL at baseline (EQ‐VAS < 75 [median]), showed improvement in sIBDQ over 6 months that became significant at month 12 and remained significant through month 18 (baseline: IG 4.24; CG 4.31; 18 months: IG 5.02; CG 4.76; p = 0.017).ConclusionHigh baseline satisfaction of IBD patients with treatment and the relatively high baseline sIBDQ values may have contributed to the lack of significant difference in sIBDQ scores for the overall sample. However, patients with impaired QoL derived significant benefit from additional care provided by an IBD nurse specialist, leading to meaningful improvements in sIBDQ over the long term.
Effectiveness and safety of a third‐line rescue treatment for acute severe ulcerative colitis refractory to infliximab or ciclosporin (REASUC study)
Authors: García María José , Riestra Sabino , Amiot Aurelien , Julsgaard Mette , García de la Filia Irene , Calafat Margalida , Aguas Mariam , de la Peña Luisa , Roig Cristina , Caballol Berta , Casanova María José , Farkas Klaudia , Boysen Trine , Bujanda Luis , Cuarán Camila , Dobru Daniela , Fousekis Fotios , Gargallo‐Puyuelo Carla Jerusalén , Savarino Edoardo , Calvet Xavier , Huguet José María , Kupcinskas Limas , López‐Cardona Julia , Raine Tim , van Oostrom Joep , Gisbert Javier P. , Chaparro María 
Published: March 2024

SummaryBackgroundThe advent of new therapeutic agents and the improvement of supporting care might change the management of acute severe ulcerative colitis (ASUC) and avoid colectomy.AimsTo evaluate the colectomy‐free survival and safety of a third‐line treatment in patients with ASUC refractory to intravenous steroids and who failed either infliximab or ciclosporin.MethodsMulticentre retrospective cohort study of patients with ASUC refractory to intravenous steroids who had failed infliximab or ciclosporin and received a third‐line treatment during the same hospitalisation. Patients who stopped second‐line treatment due to disease activity or adverse events (AEs) were eligible. We assessed short‐term colectomy‐free survival by logistic regression analysis. Kaplan–Meier curves and Cox regression models were used for long‐term assessment.ResultsAmong 78 patients, 32 received infliximab and 46 ciclosporin as second‐line rescue treatment. Third‐line treatment was infliximab in 45 (58%), ciclosporin in 17 (22%), tofacitinib in 13 (17%) and ustekinumab in 3 (3.8%). Colectomy was performed in 29 patients (37%) during follow‐up (median 21 weeks). Of the 78 patients, 32 and 18 were in clinical remission at, respectively, 12 and 52 weeks. At the last visit, 25 patients were still on third‐line rescue treatment, while 12 had stopped it due to clinical remission. AEs were reported in 26 (33%) patients. Two patients died (2.6%), including one following colectomy.ConclusionThird‐line rescue treatment avoided colectomy in over half of the patients with ASUC and may be considered a therapeutic strategy.
Real‐world use of thrombopoietin receptor agonists for the management of immune thrombocytopenia in adult patients in the United Kingdom: Results from the TRAIT study
Authors: Cooper Nichola , Scully Marie , Percy Charles , Nicolson Phillip L. R. , Lowe Gillian , Bagot Catherine N. , Thachil Jecko , Grech Henri , Nokes Tim , Hill Quentin A. , Bradbury Charlotte , Talks Kate , Dutt Tina , Evans Gillian , Pavord Sue , Wexler Sarah , Charania Asad , Collington Sarah J. , Ervin Andrew , Ramscar Nicholas , Provan Drew 
Published: March 2024

SummaryFew studies have reported the real‐world use of both romiplostim and eltrombopag in immune thrombocytopenia (ITP). TRAIT was a retrospective observational study aimed to evaluate the platelet responses and adverse effects associated with the use of these thrombopoietin receptor agonists (TPO‐RAs) in adult patients with ITP in the United Kingdom. Of 267 patients (median age at diagnosis, 48 years) with ITP (primary ITP [n = 218], secondary ITP [n = 49]) included in the study, 112 (42%) received eltrombopag and 155 (58%) received romiplostim as the first prescribed TPO‐RA. A platelet count ≥30 × 109/L was achieved in 89% of patients with the first TPO‐RA treatments, while 68% achieved a platelet count ≥100 × 109/L. Treatment‐free response (TFR; platelet count ≥30 × 109/L, 3 months after discontinuing treatment) was achieved by 18% of the total patients. Overall, 61 patients (23%) switched TPO‐RAs, most of whom achieved platelet counts ≥30 × 109/L with the second TPO‐RA (23/25 who switched from eltrombopag to romiplostim [92%]; 28/36 who switched from romiplostim to eltrombopag [78%]). TFR was associated with secondary ITP, early TPO‐RA initiation after diagnosis, the presence of comorbidity and no prior splenectomy or treatment with steroids or mycophenolate mofetil. Both TPO‐RAs had similar efficacy and safety profiles to those reported in clinical studies.
Geophagy by a large herbivore (capybara, Hydrochoerus hydrochaeris) driven by a human sodium supply
Authors: Duvall Ethan S. , Hoeneisen Naia Andrade , Suárez Esteban , Flecker Alexander S. 
Published: March 2024

AbstractReasons for geophagy (soil consumption) by herbivorous animals have long been debated. We provide direct evidence of artificial sodium (Na) enrichment driving geophagy by capybaras (Hydrochoerus hydrochaeris), a large herbivore in western Amazonia.Abstract in Spanish is available with online material.
Whole‐transcriptome sequencing in advanced gastric or gastroesophageal cancer: A deep dive into its clinical potential
Authors: Hashimoto Tadayoshi , Nakamura Yoshiaki , Mishima Saori , Nakayama Izuma , Kotani Daisuke , Kawazoe Akihito , Kuboki Yasutoshi , Bando Hideaki , Kojima Takashi , Iida Naoko , Shibuki Taro , Imai Mitsuho , Fujisawa Takao , Nagamine Michiko , Sakamoto Naoya , Kuwata Takeshi , Yoshino Takayuki , Shitara Kohei 
Published: March 2024

AbstractAdvanced gastric and gastroesophageal junction cancers (GC/GEJCs) harbor diverse molecular signatures, highlighting the need for intricate evaluations to identify potential therapeutic targets. Although whole‐transcriptome sequencing (WTS) has emerged as a useful tool for understanding these molecular intricacies, its clinical implications have yet to be fully elucidated. This study evaluated the correlation between immunohistochemistry (IHC) and WTS, compared their clinical significance, and identified potential therapeutic targets undetectable through IHC alone. We enrolled 140 patients with advanced GC/GEJC and assessed them using IHC for six pivotal biomarkers: claudin‐18 (CLDN18), human epidermal growth factor receptor 2 (HER2), multiple receptor tyrosine kinases (RTKs), and programmed death ligand 1 (PD‐L1). Concurrently, WTS was employed as part of the analyses in MONSTAR‐SCREEN‐2, a multicenter multiomics study. IHC analysis revealed 16.4% HER2, 39.3% CLDN18 (2+/3 + ≥75%), and 15.8% PD‐L1 (combined positive score ≥ 10) positivity, among other molecular markers. Significant correlations were observed between IHC and WTS for all six pivotal biomarkers. Among nineteen HER2 IHC‐positive patients treated with anti‐HER2 therapeutics, ERBB2 status in WTS was significantly associated with progression‐free survival (ERBB2‐high vs. ‐low: median 9.0 vs. 5.6 months, log‐rank p = 0.046). IHC‐based molecular profiling revealed significantly high expression of CLDN18 in RTK‐negative patients, with 78.4% positive for either CLDN18 or PD‐L1. Additionally, WTS revealed elevated expression of pivotal biomarkers in patients displaying negative targetable biomarkers via IHC. Our findings highlighted the significant correlation between IHC and WTS, reinforcing the clinical utility of WTS. A subset with IHC‐negative but WTS‐positive status may benefit from specific biomarker‐targeted therapies.
Is the NHS low‐calorie diet programme delivered as planned? An observational study examining adherence of intervention delivery to service specification
Authors: Marwood Jordan , Kinsella Karina , Homer Catherine , Drew Kevin J. , Brown Tamara , Evans Tamla S. , Dhir Pooja , Freeman Charlotte , Jones Susan , Bakhai Chirag , Ells Louisa J. 
Published: March 2024

SummaryObesity and Type 2 Diabetes Mellitus (T2DM) are chronic conditions with significant personal, societal, and economic impacts. Expanding on existing trial evidence, the NHS piloted a 52‐week low‐calorie diet programme for T2DM, delivered by private providers using total diet replacement products and behaviour change support. This study aimed to determine the extent to which providers and coaches adhered to the service specification outlined by NHS England. An observational qualitative study was conducted to examine the delivery of both one‐to‐one and group‐based delivery of programme sessions. Observations of 122 sessions across eight programme delivery samples and two service providers were completed. Adherence to the service specification was stronger for those outcomes that were easily measurable, such as weight and blood glucose, while less tangible elements of the specification, such as empowering service users, and person‐centred delivery were less consistently observed. One‐to‐one sessions were more successful in their person‐centred delivery, and the skills of the coaches delivering the sessions had a strong impact on adherence to the specification. Overall, the results show that there was variability by provider and delivery mode in the extent to which sessions of the NHS Low‐Calorie Diet Programme reflected the intended service specification. In subsequent programmes it is recommended that one‐to‐one sessions are used, with accompanying peer support, and that providers improve standardised training and quality assurance to ensure specification adherence.
Protecting alpine biodiversity in the Middle East from climate change: Implications for high‐elevation birds
Authors: Ahmadi Mohsen , Nawaz Muhammad Ali , Asadi Hamed , Hemami Mahmoud‐Reza , Naderi Morteza , Shafapourtehrany Mahyat , Shabani Farzin 
Published: March 2024

AbstractAimsThe Middle East, located in the arid belt of the Earth, is home to a diverse range of biodiversity, with its mountain ecosystems being the most important centres of species diversity and endemism. In this study, the impact of climate change on alpine bird species in the Middle East was assessed across five mountain systems: Alborz–Kopet‐Dagh, Caucasus–Pontic, Levant–Taurus, Sarawat–Hijaz and Zagros–Central Iran.LocationMiddle East.MethodsUsing species distribution models (SDMs), 38 native alpine bird species were analysed under different climate change scenarios. We also identified future multispecies in situ and ex situ climate refugia and assessed the efficiency of the current protected areas (PAs) system in protecting them.ResultsThe results indicated that, on average, habitat suitability for these species is projected to decline by 36.83% (2050, SSP2‐4.5) to 60.10% (2070, SSP5‐8.5) with an upward range shift. Based on stacking range change of the species, Levant–Taurus, Zagros–Central Iran and Alborz–Kopet–Dagh mountain ranges will experience the highest amount of habitat loss, respectively, with Caucasus–Pontic being least affected. The gap analysis showed that the existing PAs system covers only 13% and 10% of the in situ and ex situ climatic refugia, respectively.ConclusionsOur findings underscore the significance of mountainous regions in the Middle East for the persistence of alpine bird species and the urgent need to prioritize climate refugia in transboundary and participatory conservation plans. It is crucial to prevent habitat degradation and alteration resulting from human activities in these areas to ensure the persistence of alpine species and their habitats.
Measuring functional hand use in children with unilateral cerebral palsy using accelerometry and machine learning
Authors: Mathew Sunaal P. , Dawe Jaclyn , Musselman Kristin E. , Petrevska Marina , Zariffa José , Andrysek Jan , Biddiss Elaine 
Published: March 2024

AbstractAimTo investigate wearable sensors for measuring functional hand use in children with unilateral cerebral palsy (CP).MethodDual wrist‐worn accelerometry data were collected from three females and seven males with unilateral CP (mean age = 10 years 2 months [SD 3 years]) while performing hand tasks during video‐recorded play sessions. Video observers labelled instances of functional and non‐functional hand use. Machine learning was compared to the conventional activity count approach for identifying unilateral hand movements as functional or non‐functional. Correlation and agreement analyses compared the functional usage metrics derived from each method.ResultsThe best‐performing machine learning approach had high precision and recall when trained on an individual basis (F1 = 0.896 [SD 0.043]). On an individual basis, the best‐performing classifier showed a significant correlation (r = 0.990, p < 0.001) and strong agreement (bias = 0.57%, 95% confidence interval = −4.98 to 6.13) with video observations. When validated in a leave‐one‐subject‐out scenario, performance decreased significantly (F1 = 0.584 [SD 0.076]). The activity count approach failed to detect significant differences in non‐functional or functional hand activity and showed no significant correlation or agreement with the video observations.InterpretationWith further development, wearable accelerometry combined with machine learning may enable quantitative monitoring of everyday functional hand use in children with unilateral CP.What this paper adds

Wearable (wrist‐worn) accelerometry with machine learning shows potential for measuring functional hand use in children with unilateral cerebral palsy.
Traditional activity count accelerometry cannot distinguish functional from non‐functional hand use.