bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract LB126: Generation of a novel ROR1 x CD3 bispecific T-cell engager for better tumor killing and minimal cytokine release
Authors: Wu Danqing , Gong Shiyong , Wu Xuan , Naren Gaowa , Dong Liqin , Lensky Stephan , Wu Chengbin 
Published: April 2024

Abstract
Receptor tyrosine kinase-like orphan receptor 1 (ROR1) expression is a highly specific tumor associated antigen expressed in multiple hematological malignancies and solid tumors. EMB-07 is a novel monovalent asymmetrical tandem Fab (MAT-Fab) antibody composed of two different Fab fragments targeting ROR1 and CD3ε respectively, and a “knob-in-hole” Fc fragment maintaining FcRn binding and Ig-like pharmacokinetics in vivo. To avoid light chain miss-pairing, the anti-ROR1 light chain was directly connected to the N-terminus of the anti-CD3 heavy chain. The ROR1 binding arm has a high affinity of 0.52 nM and recognizes a membrane distal epitope, which is different from a reference BiTE molecule currently in clinical trial. In comparison with this BiTE molecule, EMB-07 showed similar tumor killing efficacy to ROR1 expressing tumor cell lines while it induced much lower levels of cytokines both in vitro and in vivo. Moreover, comparing with a clinical stage ROR1-vc-MMAE ADC, EMB-07 demonstrated ~500-fold increased tumor lysis potency in vitro. In PD-1 resistant tumor xenograft mice models, EMB-07 showed potent tumor growth inhibition and synergistic activity in combination with PD-1 blockade. In a preclinical GLP toxicological study, EMB-07 was well tolerated in cynomolgus monkeys with no evidence of lethality, life-threatening toxicity, or obvious EMB-07-related macroscopic and histopathological adverse findings up to 50 mg/kg. By using a highly specific IHC clone, we validated membrane-associated ROR1 expression in multiple tumor types, including triple negative breast cancer, ovarian cancer, endometrial cancer, lung adenocarcinoma, and pancreatic cancer, while the observation of its expression in normal tissues is very limited. This study supports the clinical development of EMB-07 for treating multiple solid tumors with ROR1 expression. A FIH study of EMB-07 in locally advanced/metastatic solid tumors or relapse/refractory lymphoma is currently ongoing (NCT05607498).
Citation Format: Danqing Wu, Shiyong Gong, Xuan Wu, Gaowa Naren, Liqin Dong, Stephan Lensky, Chengbin Wu. Generation of a novel ROR1 x CD3 bispecific T-cell engager for better tumor killing and minimal cytokine release [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 2 (Late-Breaking, Clinical Trial, and Invited Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(7_Suppl):Abstract nr LB126.
Abstract LB150: The effect of a technology-based intervention on various needs for help among Asian American breast cancer survivors
Authors: Im Eun-Ok , Chee Wonshik ,   TICAA Research Team
Published: April 2024

Abstract
Purpose: Asian American breast cancer survivors reportedly have high needs for help during their cancer survivorship process. Especially, the recent COVID19 pandemic with Anti-Asian racism exacerbated their situation with lack of information and support. To address their needs for help, there is a clear necessity for an innovative method of delivering information and coaching/support mainly due to their cultural stigma attached to breast cancer. A technology-based approach would work well for this specific population because of non-face-to-face interactions. Thus, a technology-based information and coaching/support program was developed based on the Bandura’s self-efficacy theory and pilot-tested among this specific population. In this study, the effect of the technology-based program was examined on various needs for help among a larger group of Asian American breast cancer survivors.
Methods: This study used a randomized clinical trial design with repeated measures. The study included 199 participants who were recruited through both online and offline communities/groups for Asian Americans. With multiple measurement scales related to background characteristics and theory-based mediators, the Support Care Needs Survey-34 Short Form (SCNS) was used to measure various needs for help. The SCNS included five subscales on psychological, information, physical, support, and communication needs. Data were analyzed using an intent-to-treat approach and mediation analyses.
Results: All types of needs except support needs decreased over time (p &lt; .001). However, there were no significant group * time effects. Among all the theory-based mediators, only social support significantly mediated the effects of the program on psychological, information, and support needs at the pre-test and the post-1 month.
Conclusions: This study supported significant effects of the technology-based program on various needs for help among Asian American breast cancer survivors. Future research needs to be conducted with other racial/ethnic minority groups of cancer survivors to confirm the findings reported in this presentation.
Citation Format: Eun-Ok Im, Wonshik Chee, TICAA Research Team. The effect of a technology-based intervention on various needs for help among Asian American breast cancer survivors [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 2 (Late-Breaking, Clinical Trial, and Invited Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(7_Suppl):Abstract nr LB150.
Unlocking near-whole-brain, layer-specific functional connectivity with 3D VAPER fMRI
Authors: Chai Yuhui , Morgan A. Tyler , Xie Hua , Li Linqing , Huber Laurentius , Bandettini Peter A. , Sutton Bradley P. 
Published: April 2024

Abstract
Neuroscientific investigations at the cortical layer level not only enrich our knowledge of cortical micro-circuitry in vivo, but also help bridge the gap between macroscopic (e.g., conventional fMRI, behavior) and microscopic (e.g., extracellular recordings) measures of brain function. While laminar fMRI studies have extensively explored the evoked cortical response in multiple subsystems, the investigation of the laminar component of functional networks throughout the entire brain has been hindered due to constraints in high-resolution layer-fMRI imaging methodologies. Our study addresses this gap by introducing an innovative layer-specific 3D VAPER (integrated VASO and Perfusion contrast) technique in humans at 7 T, for achieving fMRI at high resolution (800 µm isotropic), high specificity (not biased toward unspecific vein signals as BOLD), high sensitivity (robust measurement at submillimeter resolution), high spatial accuracy (analysis in native fMRI space), near-whole-brain coverage (cerebellum not included), and eventually extending layer fMRI to more flexible connectivity-based experiment designs. To demonstrate its effectiveness, we collected 0.8-mm isotropic fMRI data during both resting-state and movie-watching scenarios, established a layer-specific functional connectivity analysis pipeline from individual to group levels, and explored the role of different cortical layers in maintaining functional networks. Our results revealed distinct layer-specific connectivity patterns within the default mode, somatomotor, and visual networks, as well as at the global hubness level. The cutting-edge technique and insights derived from our exploration into near-whole-brain layer-specific connectivity provide unparalleled understanding of the organization principles and underlying mechanisms governing communication between different brain regions.
Reduced cortical complexity in ventromedial prefrontal cortex is associated with a greater preference for risky and immediate rewards
Authors: Bergström Fredrik , Lerman Caryn , Kable Joseph W. 
Published: April 2024

Abstract
In our everyday lives, we are often faced with situations in which we make choices that involve risky or delayed rewards. However, the extent to which we are willing to accept larger risky (over smaller certain) or larger delayed (over smaller immediate) rewards varies across individuals. Here, we investigated the relationship between cortical complexity in the medial prefrontal cortex and individual differences in risky and intertemporal preferences. We found that reduced cortical complexity in left ventromedial prefrontal cortex (vmPFC) was associated with a greater preference for risky and immediate rewards. In addition to these common structural associations in left vmPFC, we also found associations between lower cortical complexity and a greater preference for immediate rewards that extended into the left dorsomedial prefrontal cortex and right vmPFC. Furthermore, these structural associations occurred in a context where a preference for risky rewards was correlated with a preference for delayed rewards across individuals. These results suggest that risk and intertemporal preferences are distinct but related, and likely influenced by multiple neurocognitive processes, with cortical complexity in vmPFC reflecting one shared aspect possibly related to impulsiveness in terms of risky and impatient economic choice. Future work should elucidate the complex relationships between brain structure and behavioral preferences.
Reward Reinforcement Creates Enduring Facilitation of Goal-directed Behavior
Authors: Ballard Ian C. , Waskom Michael , Nix Kerry C. , D’Esposito Mark 
Published: April 2024

Abstract
Stimulus–response habits benefit behavior by automatizing the selection of rewarding actions. However, this automaticity can come at the cost of reduced flexibility to adapt behavior when circumstances change. The goal-directed system is thought to counteract the habit system by providing the flexibility to pursue context-appropriate behaviors. The dichotomy between habitual action selection and flexible goal-directed behavior has recently been challenged by findings showing that rewards bias both action and goal selection. Here, we test whether reward reinforcement can give rise to habitual goal selection much as it gives rise to habitual action selection. We designed a rewarded, context-based perceptual discrimination task in which performance on one rule was reinforced. Using drift-diffusion models and psychometric analyses, we found that reward facilitates the initiation and execution of rules. Strikingly, we found that these biases persisted in a test phase in which rewards were no longer available. Although this facilitation is consistent with the habitual goal selection hypothesis, we did not find evidence that reward reinforcement reduced cognitive flexibility to implement alternative rules. Together, the findings suggest that reward creates a lasting impact on the selection and execution of goals but may not lead to the inflexibility characteristic of habits. Our findings demonstrate the role of the reward learning system in influencing how the goal-directed system selects and implements goals.
Neural Tracking of Perceived Parent, but Not Peer, Norms Is Associated with Longitudinal Changes in Adolescent Attitudes about Externalizing Behaviors
Authors: Do Kathy T. , Prinstein Mitchell J. , Lindquist Kristen A. , Telzer Eva H. 
Published: April 2024

Abstract
Adolescents' perceptions of parent and peer norms about externalizing behaviors influence the extent to which they adopt similar attitudes, yet little is known about how the trajectories of perceived parent and peer norms are related to trajectories of personal attitudes across adolescence. Neural development of midline regions implicated in self–other processing may underlie developmental changes in parent and peer influence. Here, we examined whether neural processing of perceived parent and peer norms in midline regions during self-evaluations would be associated with trajectories of personal attitudes about externalizing behaviors. Trajectories of adolescents' perceived parent and peer norms were examined longitudinally with functional neuroimaging (n = 165; ages 11–16 years across three waves; 86 girls, 79 boys; 29.7% White, 21.8% Black, 35.8% Latinx, 12.7% other/multiracial). Behavioral results showed perceived parent norms were less permissive than adolescents' own attitudes about externalizing behaviors, whereas perceived peer norms were more permissive than adolescents' own attitudes, effects that increased from early to middle adolescence. Although younger adolescents reported less permissive attitudes when they spontaneously tracked perceived parent norms in the ventromedial and medial pFCs during self-evaluations, this effect weakened as they aged. No brain–behavior effects were found when tracking perceived peer norms. These findings elucidate how perceived parent and peer norms change in parallel with personal attitudes about externalizing behaviors from early to middle adolescence and underscore the importance of spontaneous neural tracking of perceived parent norms during self-evaluations for buffering permissive personal attitudes, particularly in early adolescence.
Multi-hierarchy Network Configuration Can Predict Brain States and Performance
Authors: Wang Bin , Yuan Yuting , Yang Lan , Huang Yin , Zhang Xi , Zhang Xingyu , Yan Wenjie , Li Ying , Li Dandan , Xiang Jie , Yang Jiajia , Liu Miaomiao 
Published: April 2024

Abstract
The brain is a hierarchical modular organization that varies across functional states. Network configuration can better reveal network organization patterns. However, the multi-hierarchy network configuration remains unknown. Here, we propose an eigenmodal decomposition approach to detect modules at multi-hierarchy, which can identify higher-layer potential submodules and is consistent with the brain hierarchical structure. We defined three metrics: node configuration matrix, combinability, and separability. Node configuration matrix represents network configuration changes between layers. Separability reflects network configuration from global to local, whereas combinability shows network configuration from local to global. First, we created a random network to verify the feasibility of the method. Results show that separability of real networks is larger than that of random networks, whereas combinability is smaller than random networks. Then, we analyzed a large data set incorporating fMRI data from resting and seven distinct tasking conditions. Experiment results demonstrates the high similarity in node configuration matrices for different task conditions, whereas the tasking states have less separability and greater combinability between modules compared with the resting state. Furthermore, the ability of brain network configuration can predict brain states and cognition performance. Crucially, derived from tasks are highlighted with greater power than resting, showing that task-induced attributes have a greater ability to reveal individual differences. Together, our study provides novel perspectives for analyzing the organization structure of complex brain networks at multi-hierarchy, gives new insights to further unravel the working mechanisms of the brain, and adds new evidence for tasking states to better characterize and predict behavioral traits.
Early Electrophysiological Correlates of Perceptual Consciousness Are Affected by Both Exogenous and Endogenous Attention
Authors: Doradzińska Łucja , Bola Michał 
Published: April 2024

Abstract
It has been proposed that visual awareness negativity (VAN), which is an early ERP component, constitutes a neural correlate of visual consciousness that is independent of perceptual and cognitive mechanisms. In the present study, we investigated whether VAN is indeed a specific marker of phenomenal awareness or rather reflects the involvement of attention. To this end, we reanalyzed data collected in a previously published EEG experiment in which awareness of visual stimuli and two aspects that define attentional involvement, namely, the inherent saliency and task relevance of a stimulus, were manipulated orthogonally. During the experimental procedure, participants (n = 41) were presented with images of faces that were backward-masked or unmasked, fearful or neutral, and defined as task-relevant targets or task-irrelevant distractors. Single-trial ERP analysis revealed that VAN was highly dependent on attentional manipulations in the early time window (140–200 msec), up to the point that the effect of awareness was not observed for attentionally irrelevant stimuli (i.e., neutral faces presented as distractors). In the late time window (200–350 msec), VAN was present in all attentional conditions, but its amplitude was significantly higher in response to fearful faces and task-relevant face images than in response to neutral ones and task-irrelevant ones, respectively. In conclusion, we demonstrate that the amplitude of VAN is highly dependent on both exogenous (stimulus saliency) and endogenous attention (task requirements). Our results challenge the view that VAN constitutes an attention-independent correlate of phenomenal awareness.
Research and Creative Activity in the Design Field: Intersections of Science, Art, and Engineering
Authors: Gryshchenko Ivan , Yezhova Olga , Pashkevich Kalina , Biryukova Yulia 
Published: April 2024

Abstract
This case study assesses the development of research competence among graduate design students through a Ukrainian–Chinese English-language remote learning program. The quasi-experimental study included one group of 19 students who enrolled in the course, titled “Research Methodology and Modern Technology of Design Activity.” The extent to which the course improved their confidence in using the English language and their self-assessed readiness to engage in professional activities at the intersection of science, design, and engineering were used as the outcome measures. After 3 weeks of the program, all students reported improved readiness to participate in the scientific community through the English language, demonstrating their ability to perform research and creative activity in the field of design.
History of Error: Jacob Taubes’s Apocalyptic Interpretation of Martin Heidegger’s Vom Wesen der Wahrheit
Authors: Styfhals Willem 
Published: April 2024

Abstract
Through a close reading of the opening pages of Occidental Eschatology, this paper analyzes how Jacob Taubes relied on Martin Heidegger’s philosophy to understand the nature of eschatology. Taubes implemented Heidegger’s notions of truth, error, and history from his seminal essay “On the Essence of Truth,” (mis)interpreting the essay by ascribing an eschatological meaning to it. This surprisingly allowed him to find in Heidegger a model to come to terms with the Jewish experience of history. In order to fully understand this untimely use of Heidegger’s work, the paper turns its attention to the correspondence of Jacob Taubes with his first wife, Susan Taubes. The conclusion asks to what extent Jacob Taubes’s uncritical use of Heidegger’s thinking plays into the latter’s notorious antisemitism.
Hermeneutics before Ontology: How Later Levinas Better Understands Heidegger
Authors: Lapidot Elad 
Published: April 2024

Abstract
This paper examines Emmanuel Levinas’s philosophical development from Totality and Infinity to Otherwise than Being as a self-critique and revised understanding of Martin Heidegger. It focuses on later Levinas’s analysis of language in terms of the difference between Saying and Said. For Levinas, the Said represents the betrayal of ethical Saying into ontological essence. This echoes Heidegger’s notion of the forgetfulness of Being in beings. However, Levinas critiques Heidegger’s own philosophy as remaining within the Said. The paper explores three strategies of “unsaying” that Levinas discerns in Western philosophy to disrupt ontological Said: ontology itself, skepticism, and philosophical conversation. It argues that Levinas ultimately seeks an alternative “prophetic” mode of language beyond philosophy that enacts difference, which the paper relates to Talmud. The paper claims that the later Levinas no longer simply opposes Greek to Jewish thought, but rather seeks to deploy a specifically Jewish form of language to interrupt Western metaphysics from within.
Elective Affinity: the Geist of Israel in Heidegger’s Free Use of the German National
Authors: Fagenblat Michael 
Published: April 2024

Abstract
This article examines the way Heidegger’s account of the unique spiritual mission of the German people is haunted by certain conceptions of the election of Israel. I argue that Heidegger’s political ontology is informed by three conceptions of the mission of Israel: biblical salvation history, kabbalistic panentheism, and Germany literary Hebraism. To link these disparate historical phenomena to Heidegger’s account of the mission of being German, I develop a methodological approach for understanding Heidegger’s “free use of the national” that accounts for the way it binds different sources into a new figure that is haunted by the spirit of Israel.
Greek and Latin Texts on the Harp and Similar Instruments in Byzantine Times
Authors: Najock Dietmar 
Published: April 2024

Abstract
In Byzantine sources, both literary and iconographic, the harp occurs surprisingly seldom. Harpa as a term for a musical instrument is first encountered in Venantius Fortunatus. It is usually translated as ‘harp’, but at that time it most likely meant a lyre. Since the Carolingian Renaissance – when in the West often the harp, in Byzantium the psaltery gradually took the place of the lyre – the old name apparently passed to the new instrument, as similarly in the cases of cithara and ψαλτήριον. The name harpa was apparently adopted into Greek only at the end of the 14th century under Italian influence. Πλινθίον probably referred to the rectangular psaltery in Byzantium. Ἀχιλλιακόν may have meant a rare instrument in Byzantium, probably due to a misunderstanding of our Fortunatus passage.
Not So Vats: How Early Is Too Early in the Operative Management of Patients with Traumatic Hemothorax?
Authors: Uma Chinweotuto V. , Risinger William B. , Nath Suhail , Pera Samuel J. , Smith Jason W. 
Published: April 2024

Background Video-assisted thoracoscopic surgery (VATS) is a practical resource in the management of traumatic hemothorax. However, it carries inherent risks and should be mobilized cost-effectively. In this study, we investigated the ideal VATS timing using cost analysis. Methods 617 cases of unilateral traumatic hemothorax from 2012 to 2022 were identified in our trauma database. We extracted encounter cost, length of stay (LOS), and operative cost information. Using Kruskal-Walli’s test, we compared the cost and LOS for patients who underwent VATS or continued nonoperative management in the first 7 days of admission. Additionally, we computed the daily proportion of patients initially managed nonoperatively but ultimately underwent VATS. P-values <.05 were considered significant. Results The median encounter cost of cases managed operatively before hospital day 4 (HD4) was higher than those managed nonoperatively. This difference was $63k on HD2 ( P-value .07) and was statistically significant for HD3 (difference of $65k, P-value .02). The median LOS with operational management on HD2 and 3 was 7 and 6 respectively vs median LOS of 2 and 3 with nonoperative management on those days ( P-value <.001, .01 respectively). The proportion of patients who failed nonoperative management did not change from baseline until HD4 (23% (95% CI 19.7, 26.3) vs 33.9% (95% CI 28.3, 39.6), P-value <.001). Discussion Early mobilization of VATS before hospital day 4 increases the overall hospital cost without offering any length of stay benefit. Continuing nonoperative management longer than 4 days is associated with a high failure rate and a costlier operation.