bluuebunny/crossref_metadata_2025_split huggingface dataset:
Secure and lightweight message dissemination framework for internet of vehicles
Authors: Bodkhe Umesh , Tanwar Sudeep 
Published: March 2024

AbstractThe Internet of Vehicles (IoV) revolutionizes vehicle communication in dynamic networks. Message dissemination in IoV involves sharing critical information for the safety and convenience of the IoV network. It is very crucial to secure message dissemination due to potential cyber‐attacks, traffic disruptions, and privacy breaches. Data integrity, authentication, and privacy are vital to maintaining trust and safety in the IoV network. This network consists of resource‐constrained IoV devices with limited resources due to the availability of embedded components in vehicular systems. Therefore, optimizing algorithms and protocols is crucial for efficient vehicle‐to‐everything (V2X) communication, enhancing safety and transportation efficiency. Solutions often include lightweight protocols and secure message exchange. This paper proposes a machine learning (ML) based secure and lightweight message dissemination framework for resource‐constrained IoV. First, we present an ML‐based threat classification model capable of effectively categorizing adversarial and nonadversarial data streams and delivering an optimized model with superior accuracy. Furthermore, we also propose a secure message dissemination scheme using lightweight cryptographic primitives, which significantly reduces computational, communication, and energy overhead. To validate the robustness of our proposed ML‐based secure and lightweight message dissemination framework, we evaluate it using various security parameters and performance measures such as computation cost, communication cost, energy cost, accuracy, precision, recall, and F1‐score. Our contributions promise to significantly enhance the security and efficiency of message dissemination in IoV environments and advance lightweight, secure, and reliable transportation systems for the future.
SoTL in student affairs graduate preparation programs
Authors: Gansemer‐Topf Ann M. , Haber‐Curran Paige , Dean‐Scott Shannon R. , McKenzie Brenda L. , Dunston Emelia , Schrum Kelly , Elliott Diane Cardenas , Lange Alex C. , Bylsma Paul E. , Braxton John M. 
Published: March 2024

AbstractIn the previous article, we defined the scholarship of teaching and learning (SoTL) and the scholarship of practice (SoP) and identified characteristics and qualities related to these topics. In this article, we provide examples of scholars who have conducted a SoTL project related to student affairs. Each of these entries describes the project and gives us insights into why scholars choose to engage in this work and the impact of their work on teaching and learning.
Flexural performance of bamboo fiber‐reinforced concrete mixed with seawater and sea sand
Authors: Li Haitao , Feng Zixian , Sayed Usama , Adjei Patrick , Xue Xin , Wang Ziang , Corbi Ottavia 
Published: March 2024

AbstractIn the face of the huge consumption of fresh water and river sand by the concrete industry and the poor flexural performance of plain concrete, it is theoretically feasible and environmentally friendly to use bamboo fiber as a replacement to reinforce concrete mixed with seawater and sea sand. In this research, taking the volume fraction (0.6%, 1.2%, and 2.4%), aspect ratio (10, 20, and 30) and diameter (1.0, 1.5, and 2.0 mm) of bamboo fibers as parameters, 15 groups of bamboo fiber‐reinforced concrete (BFRC) prisms and one control group of plain seawater sea sand concrete prisms were subjected to four‐point bending test, followed by analyzing the crack pattern, ultimate load, mid‐span deflection and strain. Under the condition of 1.2% volume fraction, 20 aspect ratio, 1.5 mm diameter, and 30 mm length, the maximum increase rate of flexural strength in this research was obtained, and then it was compared with that of flexural strength of concrete prisms reinforced by various natural fibers. In addition, relevant fitting equations and theoretical calculation formulas were derived, laying a foundation for the subsequent research and application of BFRC.
Screening of azo dye biosorption efficacy of free, immobilized, indigenous bacterial strains associated with azo dye contaminated river water—An in vitro study
Authors: Varshan G. S. Amrish , Namasivayam S. Karthick Raja , Viswanathan S. , R Sowmya , Vellaiammal C. Saranya 
Published: March 2024

AbstractAzo dye degradation utilizing microorganisms has acquired significance over the last decades, owing to its beneficial properties such as rapid degradation, economic feasibility, and eco‐friendly. In this work, azo dyes (Methyl red and methylene blue) degradation efficacy using indigenous bacterial strains Pseudomonas sp. and Bacillus sp. as free and immobilized cells were investigated under in vitro batch decolorization setup was carried. Most importantly, the bacterial cells of both strains were immobilized with sodium alginate and the immobilized cells were evaluated for dye decolorization efficacy under laboratory conditions. An eco‐toxic assessment of the degraded products was done using in vitro phytotoxicity tests and in silico analyses. Among the free and immobilized cells, maximum decolorization efficacy was observed in the Pseudomonas sp. immobilized cells which exhibited 74.5% decolorization efficacy, and the maximum decolorization efficacy of free cells was 63% of was observed. Ecotoxicity of the dye‐degraded products was screened by determination of phytotoxicity. Seedlings emergence of groundnut seeds exposed to degraded dye products revealed phytotoxicity. Results indicated that degraded dye products of methyl red derived from Pseudomonas sp. showed 93.0% seedling emergence, and methylene blue‐degraded products Pseudomonas sp. degraded dye products supported 92.0% seedling emergence, respectively. Bacterial cells immobilized with biocompatible polymers can be effectively utilized in wastewater treatment without affecting the ecological components. The findings highlight the value of this work in contributing to the domain of sustainable and eco‐friendly wastewater treatment technology.
Adaptation pathways for effective responses to climate change risks
Authors: Muccione Veruska , Haasnoot Marjolijn , Alexander Peter , Bednar‐Friedl Birgit , Biesbroek Robbert , Georgopoulou Elena , Le Cozannet Gonéri , Schmidt Daniela N. 
Published: March 2024

AbstractClimate related changes are already affecting every area of our world and will increasingly do so as global warming increases, resulting in compounding and cascading risks across multiple locations and sectors. Deliberative processes and anticipatory actions are required to adapt to the associated complex and uncertain systemic risks, with dynamic and long‐term planning needed even where there is limited knowledge of the effectiveness of adaptation. In this focus article, we examine the adaptation pathways developed for the Europe Chapter of the IPCC AR6. We argue that illustrative pathways built on quantitative and qualitative assessment of adaptation effectiveness can inform adaptation planning to manage the increasing severity of risks. We find that as the global warming level increases adaptation pathways can diverge, leading to radically different futures, for example, adaptation responses to sea level rise. We illustrate how adaptation measures for different risks interact resulting in trade‐offs, for example, increasing water scarcity. Although pathways offer a useful framework to address multiple adaptation challenges, other supporting conditions are needed for the successful implementation of adaptation, such as establishing legitimacy and buy‐in through collaboration of various actors and effective governance. Ultimately, adaptation will be increasingly more complex and constrained in a warmer world, increasing risks of losses and damages to people and nature.This article is categorized under:
Vulnerability and Adaptation to Climate Change > Institutions for Adaptation
The Social Status of Climate Change Knowledge > Climate Science and Decision Making
Assessing Impacts of Climate Change > Evaluating Future Impacts of Climate Change
Vulnerability and Adaptation to Climate Change > Learning from Cases and Analogies
Target‐directed microRNA degradation: Mechanisms, significance, and functional implications
Authors: Hiers Nicholas M. , Li Tianqi , Traugot Conner M. , Xie Mingyi 
Published: March 2024

AbstractMicroRNAs (miRNAs) are small non‐coding RNAs that play a fundamental role in enabling miRNA‐mediated target repression, a post‐transcriptional gene regulatory mechanism preserved across metazoans. Loss of certain animal miRNA genes can lead to developmental abnormalities, disease, and various degrees of embryonic lethality. These short RNAs normally guide Argonaute (AGO) proteins to target RNAs, which are in turn translationally repressed and destabilized, silencing the target to fine‐tune gene expression and maintain cellular homeostasis. Delineating miRNA‐mediated target decay has been thoroughly examined in thousands of studies, yet despite these exhaustive studies, comparatively less is known about how and why miRNAs are directed for decay. Several key observations over the years have noted instances of rapid miRNA turnover, suggesting endogenous means for animals to induce miRNA degradation. Recently, it was revealed that certain targets, so‐called target‐directed miRNA degradation (TDMD) triggers, can “trigger” miRNA decay through inducing proteolysis of AGO and thereby the bound miRNA. This process is mediated in animals via the ZSWIM8 ubiquitin ligase complex, which is recruited to AGO during engagement with triggers. Since its discovery, several studies have identified that ZSWIM8 and TDMD are indispensable for proper animal development. Given the rapid expansion of this field of study, here, we summarize the key findings that have led to and followed the discovery of ZSWIM8‐dependent TDMD.This article is categorized under:
Regulatory RNAs/RNAi/Riboswitches > Regulatory RNAs
RNA Turnover and Surveillance > Turnover/Surveillance Mechanisms
RNA in Disease and Development > RNA in Development
Ostarine blunts the effect of endurance training on submaximal endurance in rats
Authors: Vasilev Veselin , Boyadjiev Nikolay , Hrischev Petar , Gerginska Fanka , Delchev Slavi , Arabadzhiyska Desislava , Komrakova Marina , Boeker Kai O. , Schilling Arndt F. , Georgieva Katerina 
Published: March 2024

AbstractThe purpose of this study is to study the effects of ostarine alone and in combination with endurance training in sexually mature, male Wistar rats. The rats were divided into a treadmill-trained group and a sedentary group. Half of each group received either ostarine or vehicle for 8 weeks (n = 10 each, in total n = 40). We examined some functional, hormonal, and anthropometric parameters and the myogenic gene expression of myostatin, insulin-like growth factor-1 (IGF-1), and vascular endothelial growth factor-A (VEGF-A) in m. gastrocnemius. Ostarine decreased submaximal endurance and increased myogenic gene expression of myostatin but had no effect on maximal time to exhaustion and grip strength. Training increased submaximal endurance, maximal time to exhaustion, and grip strength. Our results indicate that both exercise and ostarine treatment had no significant effects on serum levels of luteinizing hormone, follicle-stimulating hormone, and testosterone, or on the myogenic gene expression of IGF-1 and VEGF-A. Neither ostarine nor the training had a significant effect on the testis, liver, and heart weights. In conclusion, ostarine had no effect on anthropometric and hormonal parameters but increased the myostatin gene expression in muscle. The SARM treatment decreased submaximal endurance without affecting maximal time to exhaustion, and training increased both metrics.
Expression, purification, and characterization of transmembrane protein homogentisate solanesyltransferase
Authors: Xiao Han , Mei Long-Can , Lin Hong-Yan , Chen Zhao , Yu Xin-He , Yang Jun , Tong Qiong , Yang Guang-Fu 
Published: March 2024

Abstract
Homogentisate solanesyltransferase (HST) is a crucial enzyme in the plastoquinone biosynthetic pathway and has recently emerged as a promising target for herbicides. In this study, we successfully expressed and purified a stable and highly pure form of seven times transmembrane protein Chlamydomonas reinhardtii HST (CrHST). The final yield of CrHST protein obtained was 12.2 mg per liter of M9 medium. We evaluated the inhibitory effect on CrHST using Des-Morpholinocarbony Cyclopyrimorate (DMC) and found its IC50 value to be 3.63 ± 0.53 μM, indicating significant inhibitory potential. Additionally, we investigated the substrate affinity of CrHST with two substrates, determining the Km values as 22.76 ± 1.70 μM for FPP and 48.54 ± 3.89 μM for HGA. Through sequence alignment analyses and three-dimensional structure predictions, we identified conserved amino acid residues forming the active cavity in the enzyme. The results from molecular docking and binding energy calculations indicate that DMC has a greater binding affinity with HST compared to HGA. These findings represent substantial progress in understanding CrHST’s properties and potential for herbicide development.

Key points
• First high-yield transmembrane CrHST protein via E. coli system
• Preliminarily identified active cavity composition via activity testing
• Determined substrate and inhibitor modes via molecular docking
Obesity and tobacco smoking are independently associated with poor patient-reported outcomes in SLE: a cross-sectional study
Authors: Gomez Alvaro , Parodis Ioannis , Sjöwall Christopher 
Published: March 2024

AbstractWe investigated associations of obesity and tobacco smoking with health-related quality of life (HRQoL), pain, fatigue, and functional impairment in systemic lupus erythematosus (SLE). Furthermore, we explored whether there was an effect modification between these two factors. We included adult SLE patients from the Linköping University Hospital (n = 325) in the present cross-sectional analysis. We further included population-based controls and performed cardinality matching to balance age and sex distributions with cases (n = 224). HRQoL was assessed with the EQ-5D index score; pain, fatigue, and overall SLE-related health state with visual analogue scales (VAS; 0 [best] to 100 [worst]); and functional impairment with the HAQ-DI. Unacceptable outcomes were defined as VAS scores corresponding to the 90th percentile derived from the matched controls. SLE patients reported worse scores than controls in all measures, and approximately 30% experienced unacceptable outcomes. When compared with normal-weight, obese SLE patients reported lower HRQoL, and greater functional impairment and risk of unacceptable pain (OR: 3.2; 95% CI 1.6–6.7) and fatigue (OR: 2.1; 95% CI 1.0–4.3). Similarly, the current smokers reported higher levels of functional impairment and a greater risk of unacceptable pain (OR: 3.8; 95% CI 1.8–8.2) and fatigue (OR: 2.8; 95% CI 1.3–5.9) than never smokers. The associations were independent of age, sex, disease duration, disease activity, and organ damage. There was no evidence of a synergistic effect between increased BMI and smoking on any outcome. In summary, obesity and smoking are risk factors for unacceptable patient-reported outcomes in SLE, regardless of clinical activity.
Efficacy of lifestyle interventions in the management of systemic lupus erythematosus: a systematic review of the literature
Authors: Tsoi Alexander , Gomez Alvaro , Boström Carina , Pezzella Denise , Chow Jun Weng , Girard-Guyonvarc’h Charlotte , Stamm Tanja , Arnaud Laurent , Parodis Ioannis 
Published: March 2024

AbstractWe performed a systematic review to explore existing evidence regarding the efficacy of lifestyle interventions for the management of systemic lupus erythematosus (SLE). The search was conducted on the 22nd of June 2021 for publications between 1st of January 2000 and the date of search. Additional articles within the aforementioned timeframe and until December 2023 were added by hand searching. Databases utilized were Medline, Embase, Web of Science, and Cinahl. Lifestyle interventions were defined as any intervention encompassing one or more of the following: physical exercise, diet and nutrition, mental health, harmful exposures, sleep, and social relations. The Joanna Briggs Institute critical appraisal tools were used for risk of bias assessment. The search yielded 11,274 unique records, we assessed the full text of 199 records, and finally included 102 studies. Overall, the quality of the evidence is limited, and there were multiple sources of heterogeneity. The two domains most extensively researched were mental health (40 records) and physical exercise (39 records). Psychological interventions had a positive effect on depressive symptoms, anxiety, and health-related quality of life (HRQoL), whereas physical exercise improved fatigue, depressive symptoms, aerobic capacity, and physical functioning. Studies on diet and nutrition (15 records) support that low fat intake and Mediterranean diet may be beneficial for reducing cardiovascular risk, but large interventional studies are lacking. Studies on harmful exposures (7 records) support photoprotection and use of sunscreen. While studies imply benefits regarding disease burden and drug efficacy in non-smokers and regarding HRQoL in normal-weight patients, more survey is needed on tobacco smoking and alcohol consumption, as well as weight control strategies. Studies on social relations (1 record) and sleep (no records) were sparse or non-existent. In conclusion, psychosocial interventions are viable for managing depressive symptoms, and exercise appears essential for reducing fatigue and improving aerobic capacity and physical function. Photoprotection should be recommended to all patients. Lifestyle interventions should be considered a complement, not a substitute, to pharmacotherapy.
Long-term experiences with high-energy shock wave therapy in the management chronic phase Peyronie’s disease using two different electromagnetic lithotripters
Authors: Rassweiler Jens J. , Scheitlin W. , Goezen A. S. , Radecke F. 
Published: March 2024

Abstract
Background
Extracorporeal shock wave lithotripsy represents one option for the non-surgical management of Peyronie’s disease. Despite promising results, several questions are still pending. We want to present the long-term results of a retrospective study using high-energy extracorporeal shock wave lithotripsy.

Material and methods
We evaluated retrospectively 110 patients treated between 1996 and 2020 at the Department of Urology, SLK Kliniken Heilbronn for chronic phase Peyronie’s disease using two electromagnetic lithotripters (Siemens Lithostar Plus Overhead Module, Siemens Lithoskop) applying high-energy shock waves under local anesthesia and sonographic or fluoroscopic control. A standardized questionnaire focused on the change in pain, curvature, sexual function and the need of penile surgery.

Results
In 85 of the 110 patients (mean age 54 years) we had sufficient data for evaluation. The median follow-up was 228 (6–288) months. There were no significant complications. Pain reduction was achieved in all patients, 65 (76%) patients were free of pain. Improvement of penile curvature was achieved in 43 patients (51%) ranging from 25% improvement (deflected angle < 30°) to 95% (angle 30–60°). 59 patients (69%) reported problems with sexual intercourse, 40 of those (68%) reported improvement. Only 9 (10.5%) patients underwent surgical correction. We did not observe any significant differences between both electromagnetic devices with stable long-term results.

Conclusions
High-energy shock wave therapy delivered by two standard electromagnetic lithotripters is safe and efficient providing stable long-term results. In cases with significant plaque formation, the concept of high-energy ESWT should be considered in future studies.
Surgical outcomes of very-early-onset ulcerative colitis: retrospective comparative study with older pediatric patients
Authors: Fumita Takashi , Terui Keita , Shibata Ryohei , Takenouchi Ayako , Komatsu Shugo , Oita Satoru , Yoshizawa Hiroko , Hirano Yuichi , Yoshino Yusaku , Saito Takeshi , Hishiki Tomoro 
Published: March 2024

Abstract
Purpose
The study compares the surgical outcomes of very-early-onset ulcerative colitis (VEO-UC), which is a rare disease diagnosed in pediatric patients < 6 years, with those of older pediatric patients with ulcerative colitis (UC).

Methods
A retrospective observational study of 57 pediatric patients with UC was conducted at a single center. The study compared surgical complications and postoperative growth between the two groups.

Results
Out of the 57 patients, 6 had VEO-UC, and 5 of them underwent total colectomy. Compared with the surgical cases of older patients with UC (n = 6), the rate of postoperative complications in patients with VEO-UC (n = 5) was not significantly different, except for high-output ileostomy (80% vs. 0% at 3 weeks postoperatively, p = 0.02). The rate of postoperative central venous catheter (CVC) placement at > 90 days was higher in patients with VEO-UC (100% vs. 17%, p = 0.02). The median change in the Z-score of height before and 2 years after colectomy was not significantly different between VEO-UC and older patients (1.1 vs. 0.3, p = 0.13).

Conclusion
With regard to complications and outcomes, total colectomy for VEO-UC patients and that for older pediatric UC patients is comparable. However, high-output ileostomy and the long duration of CVC placement may pose management challenges.
New Zealand blackcurrant extract modulates the heat shock response in men during exercise in hot ambient conditions
Authors: Conrad Nathan J. , Heckler Emerson P. , Lee Ben J. , Hill Garrett W. , Flood Tessa R. , Wheeler Lucy E. V. , Costello Rianne , Walker Ella F. , Gillum Trevor L. , Willems Mark E. T. , Kuennen Matthew R. 
Published: March 2024

Abstract
Purpose
To determine if 7d of New Zealand blackcurrant (NZBC) extract alters the heat shock, inflammatory and apoptotic response during prolonged exertional-heat stress.

Methods
Ten men (Age: 29 ± 2 years, Stature: 1.82 ± 0.02 m, Mass: 80.3 ± 2.7 kg, V̇O2max: 56 ± 2 mL·kg−1·min−1) ingested two capsules of CurraNZ™ (NZBC extract: 210 mg anthocyanins·day−1) or PLACEBO for 7d prior to 1 h treadmill run (65% V̇O2max) in hot ambient conditions (34 °C/40% RH). Blood samples were collected before (Pre), immediately after (Post), 1 h after (1-Post), and 4 h after (4-Post) exercise. Heat shock proteins (HSP90, HSP70, HSP32) were measured in plasma. HSP and protein markers of inflammatory capacity (TLR4, NF-κB) and apoptosis (BAX/BCL-2, Caspase 9) were measured in peripheral blood mononuclear cells (PBMC).

Results
eHSP32 was elevated at baseline in NZBC(+ 31%; p < 0.001). In PLACEBO HSP32 content in PBMC was elevated at 4-Post(+ 98%; p = 0.002), whereas in NZBC it fell at Post(− 45%; p = 0.030) and 1-Post(− 48%; p = 0.026). eHSP70 was increased at Post in PLACEBO(+ 55.6%, p = 0.001) and NZBC (+ 50.7%, p = 0.010). eHSP90 was increased at Post(+ 77.9%, p < 0.001) and 1-Post(+ 73.2%, p < 0.001) in PLACEBO, with similar increases being shown in NZBC (+ 49.0%, p = 0.006 and + 66.2%, p = 0.001; respectively). TLR4 and NF-κB were both elevated in NZBC at PRE(+ 54%, p = 0.003 and + 57%, p = 0.004; respectively). Main effects of study condition were also shown for BAX/BCL-2(p = 0.025) and Caspase 9 (p = 0.043); both were higher in NZBC.

Conclusion
7d of NZBC extract supplementation increased eHSP32 and PBMC HSP32 content. It also increased inflammatory and apoptotic markers in PBMC, suggesting that NZBC supports the putative inflammatory response that accompanies exertional-heat stress.