bluuebunny/crossref_metadata_2025_split huggingface dataset:
An isoflavone catabolism gene cluster underlying interkingdom interactions in the soybean rhizosphere
Authors: Aoki Noritaka , Shimasaki Tomohisa , Yazaki Wataru , Sato Tomoaki , Nakayasu Masaru , Ando Akinori , Kishino Shigenobu , Ogawa Jun , Masuda Sachiko , Shibata Arisa , Shirasu Ken , Yazaki Kazufumi , Sugiyama Akifumi 
Published: April 2024

Abstract
Plant roots secrete various metabolites, including plant specialized metabolites, into the rhizosphere, and shape the rhizosphere microbiome, which is crucial for the plant health and growth. Isoflavones are major plant specialized metabolites found in legume plants, and are involved in interactions with soil microorganisms as initiation signals in rhizobial symbiosis and as modulators of the legume root microbiota. However, it remains largely unknown the molecular basis underlying the isoflavone-mediated interkingdom interactions in the legume rhizosphere. Here, we isolated Variovorax sp. strain V35, a member of the Comamonadaceae that harbors isoflavone-degrading activity, from soybean roots and discovered a gene cluster responsible for isoflavone degradation named ifc. The characterization of ifc mutants and heterologously expressed Ifc enzymes revealed that isoflavones undergo oxidative catabolism, which is different from the reductive metabolic pathways observed in gut microbiota. We further demonstrated that the ifc genes are frequently found in bacterial strains isolated from legume plants, including mutualistic rhizobia, and contribute to the detoxification of the antibacterial activity of isoflavones. Taken together, our findings reveal an isoflavone catabolism gene cluster in the soybean root microbiota, providing molecular insights into isoflavone-mediated legume–microbiota interactions.
Diplomatic Representation and Online/Offline Interactions: EU Coordination and Digital Sociability
Authors: Hedling Elsa 
Published: April 2024

Abstract
European Union (EU) diplomatic representation in third countries is performed by both the Member States and by the EU Delegation. This hybrid system of representation functions through EU coordination. As social media have become important channels of state representation, coordination also takes place in the domain of digital diplomacy. This article analyzes how the EU Member State embassies and the EU Delegation coordinate EU representation through online and offline interactions. It investigates the practices of coordination and maps routines of digital sociability. The United States’ capital Washington, DC provides a context of both strong bilateral relations and a history of shared EU interests. The study draws on observations on Twitter (later renamed X) between 2019 and 2021 and reflections from diplomats who engage in the coordination of EU representation, collected through an online survey and interviews. By examining the reciprocity between online and offline interactions, the study illuminates how relationships are cultivated, a sense of collective belonging is fostered, and social order is negotiated. The findings enhance our understanding of how digital diplomacy is deeply embedded within diplomatic contexts and their distinctive practices. They contribute to advancing knowledge about the interplay of digital diplomacy, multilateral representation, and the dynamics that shape diplomatic engagements.
Positionality Statements as a Function of Coloniality: Interrogating Reflexive Methodologies
Authors: Gani Jasmine K , Khan Rabea M 
Published: April 2024

Abstracts
Declaration of positionality and the confession of privilege as a way of revealing unequal power dynamics in knowledge production has become an increasingly encouraged reflexive practice in international relations and other disciplines. However, we interrogate the potentially negative implications of this methodology, occurring through a reification of material, assumed, and imagined hierarchies between people, which then is advertised and (re)produced by its utterance. We further query the modernist origins of reflexive methodology, which has inspired the practice of declaring positionality, and argue that its underpinning coloniality has bearings for its use today. We then explore how this coloniality manifests: Thus, first, we consider the extent to which publicly acknowledging privilege paradoxically acts as a means of centering whiteness through the narcissistic gaze and an assertion of legitimacy. Second, we argue positionality statements offer a redemption of guilt for the hegemonic researcher. And lastly, rather than ameliorating unequal power dynamics in the production of knowledge, we contend positionality statements may constitute hidden power moves in which one is able to signal and reinstate one’s authority vis-à-vis people, but especially women, of color. We end with a call for a reparative scholarship that acknowledges these limitations in positionality statements.
On-time denosumab dosing recovered rapidly during the COVID-19 pandemic, yet remains suboptimal
Authors: Rzepka Anna M , Cheung Angela M , Kim Sandra , Gomes Tara , Cadarette Suzanne M 
Published: April 2024

Abstract
Timely administration of denosumab every 6 mo is critical in osteoporosis treatment to avoid multiple vertebral fracture risk upon denosumab discontinuation or delay. This study aimed to estimate the immediate and prolonged impact of the COVID-19 pandemic on the timing of denosumab doses. We identified older adults (≥66 yr) residing in the community who were due to receive denosumab between January 2016 and December 2020 using Ontario Drug Benefit data. We completed an interrupted time-series analysis to estimate the impact of the COVID-19 pandemic (March 2020) on the monthly proportion of on-time denosumab doses (183 +/−30 d). Analyses were stratified by user type: patients due for their second dose (novice users), third or fourth dose (intermediate users), or ≥5th dose (established users). In additional analyses, we considered patients living in nursing homes, switching to other osteoporosis drugs, and reported trends until February 2022. We studied 148 554 patients (90.9% female, mean [SD] age 79.6 [8.0] yr) receiving 648 221 denosumab doses. The average pre-pandemic proportion of on-time therapy was steady in the community, yet differed by user type: 64.9% novice users, 72.3% intermediate users, and 78.0% established users. We identified an immediate overall decline in the proportion of on-time doses across all user types at the start of the pandemic: −17.8% (95% CI, −19.6, −16.0). In nursing homes, the pre-pandemic proportion of on-time therapy was similar across user types (average 83.5%), with a small decline at the start of the pandemic: −3.2% (95% CI, −5.0, −1.2). On-time therapy returned to pre-pandemic levels by October 2020 and was not impacted by therapy switching. Although on-time dosing remains stable as of February 2022, approximately one-fourth of patients in the community do not receive denosumab on-time. In conclusion, although pandemic disruptions to denosumab dosing were temporary, levels of on-time therapy remain suboptimal.
Factor IV Estimation in Conditional Moment Models with an Application to Inflation Dynamics
Authors: Antoine Bertille , Sun Xiaolin 
Published: April 2024

Abstract
In a conditional moment model, we develop a new integrated conditional moment (ICM) estimator which directly exploits factor-based conditional moment restrictions without having to first parametrize, or estimate such restrictions. We focus on a time series framework where the large number of available instruments and associated lags is driven by a relatively small number of unobserved factors. We build on the ICM principle originally proposed by Bierens (1982) and combine it with information reduction methods to handle the large number of potential instruments which may exceed the sample size. Under the maintained validity of the true factors, but not that of observed instruments, and standard regularity assumptions, our estimator is consistent, asymptotically normally distributed, and easy to compute. In our simulation studies, we document its reliability and power in cases where the underlying relationship between the endogenous variables and the instruments may be heterogeneous, non-linear, or even unstable over time. Our estimation of the New Keynesian Phillips curve with U.S. data reveals that forward- and backward-looking behaviors are quantitatively equally as important, while the driver’s role is nil.
Anterior insula is more vulnerable than posterior insula to TDP-43 pathology in common dementias and ALS
Authors: Lochner Riley H , Arumanayagam Anithachristy S , Powell Suzanne Z , Masdeu Joseph C , Pascual Belen , Cykowski Matthew D 
Published: April 2024

Abstract
Based on the anatomic proximity, connectivity, and functional similarities between the anterior insula and amygdala, we tested the hypothesis that the anterior insula is an important focus in the progression of TDP-43 pathology in LATE-NC. Blinded to clinical and neuropathologic data, phospho-TDP (pTDP) inclusion pathology was assessed in paired anterior and posterior insula samples in 105 autopsied patients with Alzheimer disease, Lewy body disease, LATE-NC and hippocampal sclerosis (HS), amyotrophic lateral sclerosis (ALS), and other conditions. Insular pTDP pathology was present in 34.3% of the study cohort, most commonly as neuronal inclusions and/or short neurites in lamina II, and less commonly as subpial processes resembling those described in the amygdala region. Among positive samples, pTDP pathology was limited to the anterior insula (41.7%), or occurred in both anterior and posterior insula (58.3%); inclusion density was greater in anterior insula across all diseases (p &lt; .001). pTDP pathology occurred in 46.7% of ALS samples, typically without a widespread TDP-43 proteinopathy. In LATE-NC, it was seen in 30.4% of samples (mostly LATE-NC stages 2 and 3), often co-occurring with basal forebrain pathology and comorbid HS, suggesting this is an important step in the evolution of this pathology beyond the medial temporal lobe.
Allelopathic potentials of surrounding vegetation on seedling establishment of alpine cushion Arenaria polytrichoides
Authors: Chen Xu-Fang , Qian Li-Shen , Shi Hong-Hua , Zhang Ya-Zhou , Song Min-Shu , Sun Hang , Chen Jian-Guo 
Published: April 2024

Abstract
When facilitating other species and sustaining plant community structures and biodiversity, alpine cushion plants simultaneously experience negative feedback effects from surrounding vegetation. However, the impact of surrounding vegetation on cushion dynamics remains poorly understood, particularly in terms of allelopathic potentials. To investigate the allelopathic potentials of surrounding vegetation on seedling establishment of the typical cushion plant Arenaria polytrichoides Edgew. along an elevational gradient, we extracted potential allelopathic compounds and tested their impacts on seed germination and seedling growth of A. polytrichoides. In addition, exclusion experiments using activated carbon were conducted to further elucidate these effects. Our results demonstrate that surrounding vegetation exhibits certain allelopathic potentials on A. polytrichoides seedling establishment, with variations observed based on elevation, source and concentration of allelopathy compounds, as well as growing season. Specifically, low-elevation vegetation exerts pronounced suppression on seedling establishment. Conversely, higher-elevation vegetation generally shows no effect on seed germination but stimulates seedling growth through allelopathy mechanisms. Moreover, aboveground vegetation predominantly inhibits both seed germination and seedling growth in low-elevation communities; however, the effects of belowground vegetation depend on elevation and extract concentration levels. The identified allelopathic potentials of surrounding vegetation significantly influence the population dynamics of cushion A. polytrichoides by potentially accelerating population degeneration in lower-elevation communities while ensuring consistent population recruitment and expansion in higher-elevation communities.
Off-label Use of Long-Acting Injectable Antiretroviral Therapy: A Single Center Retrospective Review of Youth Living With HIV With Detectable HIV RNA Starting Injectable Therapy
Authors: Rousseau Alison , McGrath Eric , Benjamins Laura , Cockern Salome , Meade Jill , Houston Keshaum , Breaux Melina , Secord Elizabeth 
Published: April 2024

Abstract
Nineteen youth living with HIV (YLWH) opted for injectable cabotegravir and rilpivirine without oral lead in and without achieving an undetectable HIV viral load (VL) for the 3 months prior to initiation. All achieved undetectable status within 3 months (3 injections) and maintained an undetectable status through 6–12 months of therapy.
How do perceptions, fears, and experiences of violence and conflict affect considerations of moving internally and internationally?
Authors: Hagen-Zanker Jessica , Rubio Marcela G , Erdal Marta Bivand 
Published: April 2024

Abstract
This article draws on cross-country survey and qualitative data for local areas within Afghanistan, Ethiopia, Nigeria, and Somalia to explore how perceptions, fears, and experiences of violence affect how young adults consider whether or not to move, internally, within their own countries, or internationally. We shed new light on how different forms and intensities of violence and conflict, ranging from tribal violence in Northern Nigeria to the encroachment of the Taliban in Afghanistan, affect these considerations. We show that, in most cases, perceiving insecurity, fearing, or having experienced violence does not result in people considering moving. However, where significant, it is specific fears and experiences that affect considerations, rather than general perceptions of insecurity. We observe distinct patterns across the local areas, related to the duration, intensity, and nature of the conflict, underscoring the salience of sub-national-level data to better understand the interplay of conflict and mobility.
Covariate-adaptive randomization inference in matched designs
Authors: Pimentel Samuel D , Huang Yaxuan 
Published: April 2024

Abstract
It is common to conduct causal inference in matched observational studies by proceeding as though treatment assignments within matched sets are assigned uniformly at random and using this distribution as the basis for inference. This approach ignores observed discrepancies in matched sets that may be consequential for the distribution of treatment, which are succinctly captured by within-set differences in the propensity score. We address this problem via covariate-adaptive randomization inference, which modifies the permutation probabilities to vary with estimated propensity score discrepancies and avoids requirements to exclude matched pairs or model an outcome variable. We show that the test achieves type I error control arbitrarily close to the nominal level when large samples are available for propensity score estimation. We characterize the large-sample behaviour of the new randomization test for a difference-in-means estimator of a constant additive effect. We also show that existing methods of sensitivity analysis generalize effectively to covariate-adaptive randomization inference. Finally, we evaluate the empirical value of combining matching and covariate-adaptive randomization procedures using simulations and analyses of genetic damage among welders and right-heart catheterization in surgical patients.
Long-term variability in debris transiting white dwarfs
Authors: Aungwerojwit Amornrat , Gänsicke Boris T , Dhillon Vikram S , Drake Andrew , Inight Keith , Kaye Thomas G , Marsh T R , Mullen Ed , Pelisoli Ingrid , Swan Andrew 
Published: April 2024

ABSTRACT
Combining archival photometric observations from multiple large-area surveys spanning the past 17 years, we detect long-term variability in the light curves of ZTF J032833.52−121945.27 (ZTF J0328−1219), ZTF J092311.41+423634.16 (ZTF J0923+4236), and WD 1145+017, all known to exhibit transits from planetary debris. ZTF J0328−1219 showed an overall fading in brightness from 2011 through to 2015, with a maximum dimming of ≃0.3 mag, and still remains ≃0.1 mag fainter compared to 2006. We complement the analysis of the long-term behaviour of these systems with high-speed photometry. In the case of ZTF J0923+4236 and WD 1145+017, the time-series photometry exhibits vast variations in the level of transit activity, both in terms of numbers of transits, as well as their shapes and depths, and these variations correlate with the overall brightness of the systems. Inspecting the current known sample of white dwarfs with transiting debris, we estimate that similar photometric signatures may be detectable in one in a few hundred of all white dwarfs. Accounting for the highly aligned geometry required to detect transits, our estimates imply that a substantial fraction of all white dwarfs exhibiting photospheric metal pollution from accreted debris host close-in planetesimals that are currently undergoing disintegration.
Evidence that Eddington ratio depends upon a supermassive black hole’s mass and redshift: implications for radiative efficiency
Authors: Aggarwal Yash 
Published: April 2024

ABSTRACT
Presently, it is unclear whether the Eddington ratio (λ) and radiative efficiency (ε) depend on a supermassive black hole’s (SMBH’s) redshift z and mass MBH. We attempt to resolve this issue using published data for 132 000 SMBHs with MBH ≥ 107 Msun (solar masses) at ∼0.1 &lt; z &lt; 2.4 covering ∼10 billion years of cosmic time, with MBH determined using Mg ii lines and bolometric luminosities Lbol based on a weighted mean of Lbol from two or more monochromatic luminosities and a single uniformly applied correction factor. The SMBHs are sorted into seven MBH bins separated from each other by half an order of magnitude. The λ and z data in each bin are subjected to spline regression analysis. The results unambiguously show that for similar-size SMBHs, λ decreases as z decreases, and that for a given redshift, larger SMBHs have a lower λ. These findings require that either an SMBH’s accretion rate and/or its radiative efficiency be a function of z and MBH and, in the context of the Bondi accretion model, imply that radiative efficiency is an inverse function of z and MBH. These findings suggest that SMBHs become less efficient (higher ε) in accreting gases as the ambient gas density decreases with z and that larger SMBHs are more efficient (lower ε) than smaller ones. The results leave little doubt that the current widespread practice of assigning ε a standard value is untenable and gives erroneous estimates of accretion rates and growth times of SMBHs.
Pushing the limits of near-infrared photometry with the Gemini Multi-Conjugate Adaptive Optics System: study of crowded fields in the globular cluster M5
Authors: Kumar Tarun , Turri Paolo , Venn Kim A , Andersen David R , Stetson Peter B , McConnachie Alan W , Taheri Mojtaba 
Published: April 2024

ABSTRACT
We present the deepest J −Ks near-infrared photometry of the globular cluster M5 (NGC 5904) from observations taken with the Gemini South Adaptive Optics Imager in tandem with the Gemini Multi-conjugate adaptive optics System (GeMS) on the 8.1-m Gemini South telescope. Point spread function (PSF) photometry was carried out using a spatially variable PSF, zero-point calibrations based on correlations to a standard photometric catalogue, colour corrections, and crowding corrections. The latter corrections provided a new challenge given the field variations of the adaptive optics corrections in the central crowded regions of this cluster. The final photometric precision in our J− Ks colour–magnitude diagram exposes a dispersion among the lower main-sequence stars of M5 for the first time. This dispersion occurs below a main-sequence knee due to variations in the helium and CNO (carbon, nitrogen, and oxygen) abundances from multiple stellar populations, consistent with results from the bright evolved stars in this cluster from ultraviolet to near-infrared Hubble Space Telescope photometry and ground-based spectroscopy. This paper completes our original GeMS quality analysis programme, providing insights into adaptive optics analyses in crowded fields.
PHL 5038AB: is the brown dwarf causing pollution of its white dwarf host star?
Authors: Casewell S L , Debes J , Dupuy T J , Dufour P , Bonsor A , Rebassa-Mansergas A , Murillo-Ojeda R , French J R , Alexander R D , Xu Siyi , Martin E , Manjavacas E 
Published: April 2024

ABSTRACT
We present new results on PHL 5038AB, a widely separated binary system composed of a white dwarf and a brown dwarf, refining the white and brown dwarf parameters and determining the binary separation to be $66^{+12}_{-24}$ au. New spectra of the white dwarf show calcium absorption lines suggesting that the hydrogen-rich atmosphere is weakly polluted, inferring the presence of planetesimals in the system, which we determine are in an S-type orbit around the white dwarf in orbits closer than 17–32 au. We do not detect any infrared excess that would indicate the presence of a disc, suggesting that all dust present either has been totally accreted or is optically thin. In this system, we suggest that the metal pollution in the white dwarf atmosphere can be directly attributed to the presence of the brown dwarf companion disrupting the orbits of planetesimals within the system.
Tracing the evolving X-ray reverberation lags within an individual AGN light curve
Authors: Nakhonthong N , Chainakun P , Luangtip W , Young A J 
Published: April 2024

ABSTRACT
We present the Granger causality (GC) test for the X-ray reverberation analysis of Active Galactic Nuclei (AGNs). If the light curves in the continuum-dominated band help predict (Granger cause) those dominated by reflection, the Granger lags that associate to the intrinsic reverberation lags can be inferred. We focus on six AGNs observed by XMM–Newton, including the sources well-known to exhibit clear X-ray reverberation lags (IRAS 13224−3809 and 1H 0707−495) and those in which reverberation signatures are not well confirmed (MCG–6-30-15, IZW1, Mrk 704, and Mrk 1040). We employ the sliding-window algorithm and estimate the Granger (intrinsic) Fe-L lags along the light curve as the window moves through. This reveals the evolving lags towards the end of some individual observations, suggesting that the corona varies progressively. Occasionally, we observe two clearly separate lags that suggest an extended corona consisting of two zones while producing competing reverberation of two lags. While the GC test is purely hypothetical and might not explain true causality, our conclusion is that the lags are present and could be understood as reverberation lags. Assuming the lags changing solely with the corona, we find that the IRAS 13224−3809 corona varies between ∼10 and 25 rg and sometimes move to ≳50 rg. The corona of 1H 0707−495 and MCG–6-30-15 may be analogous to that of IRAS 13224−3809, while in IZw1, Mrk 704, and Mrk 1040, a more compact corona is expected.