bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of pamphlets for cancer patients in disaster situations based on the study of cancer patients’ care needs
Authors: KAWASAKI Yuko , UCHINUNO Atsuko , MAKINO Sachiko , NUMATA Yasuko , KOBAYASHI Tamami , SAKASHITA Reiko , ARAO Harue 
Published: May 2007

AbstractAim:  The aim of this study is to develop a care package to help cancer patients improve their self‐care abilities and better prepare for a disaster, so that they can continue treatment and perform symptom management strategies in disaster situations.Methods:  In this study, the “Care Package for Cancer Patients in Times of Disaster”, which comprises four pamphlets, was developed through discussions among the eight members of the study group. The care package was produced by making additions and modifications, based on the findings obtained in the above two steps, to the patient education booklets developed in the area of oncology.Results:  Of the areas that cancer patients find difficult in times of disaster, the following six were extracted: difficulty in continuing treatment, the possibility of running out of pain medicines and how to store pain medicines, the possibility of not being able to go to a regular hospital, the shortage of stoma‐care appliances and other products, the possibility of exposure to infections at a shelter, and the necessity of providing care for cancer patients and their families before and after death. By incorporating these pieces of information, we developed the four pamphlets. These pamphlets are posted on the website for public use.Conclusion:  The newly developed pamphlets incorporate information on how to cope with specific situations in times of disaster, based on the findings obtained from the “Survey on Actual Conditions of Treatment and Nursing Care to Cancer Patients in Disaster Situations”.
Fatalistic Beliefs about Cancer Prevention and Three Prevention Behaviors
Authors: Niederdeppe Jeff , Levy Andrea Gurmankin 
Published: May 2007

Abstract
Background: A substantial proportion of US adults hold fatalistic beliefs about cancer prevention. Although evidence suggests that fatalistic beliefs discourage people from engaging in screening behaviors that can reduce their cancer risk, far less is known about associations between cancer fatalism and other prevention behaviors. We examined sociodemographic correlates of these beliefs and their associations with regular exercise, smoking, and fruit and vegetable consumption with a national sample of American adults.
Methods: Data were analyzed from the first wave of the Health Information National Trends Survey (HINTS 2003). HINTS used random-digit dialing to complete phone interviews with adult Americans (N = 6,369).
Results: Nearly half of respondents (47.1%) agreed that “It seems like almost everything causes cancer,” 27.0% agreed that “There's not much people can do to lower their chances of getting cancer,” and 71.5% agreed that “There are so many recommendations about preventing cancer, it's hard to know which ones to follow.” These beliefs were stronger in subjects who were less educated but generally weaker among both African Americans and Hispanics relative to Whites. Fatalistic beliefs about cancer prevention were negatively associated with exercising weekly, not smoking, and eating five or more fruits and vegetables daily in multivariate analysis controlling for sociodemographic characteristics.
Conclusions: Americans who hold fatalistic beliefs about cancer prevention may be at greater risk of cancer because they are less likely to engage in various prevention behaviors. Results have notable implications for future cancer communication and education efforts. (Cancer Epidemiol Biomarkers Prev 2007;16(5):998–1003)
The Intersection of Cancer and Aging: Establishing the Need for Breast Cancer Rehabilitation
Authors: Schmitz Kathryn H. , Cappola Anne R. , Stricker Carrie T. , Sweeney Carol , Norman Sandra A. 
Published: May 2007

Abstract
The increasing success of treatments for common cancers has resulted in growing awareness of the unique health care needs of cancer survivors. Cancer treatments can be toxic and have long-lasting effects on health, potentially accelerating the aging process and producing associated declines in physical function. In this synthesis of the literature, we critically examine the strength of existing evidence that breast cancer diagnosis and treatment are associated with a disproportionate decline in physical function compared with the effects of living without cancer for the same number of years. There is some observational epidemiologic evidence that women treated for breast cancer report greater declines in physical function than their peers. Discerning the factors associated with such declines and their clinical significance remains to be addressed. Physiologic, psychological, and behavioral changes associated with both aging and cancer treatment are reviewed. Parallels are proposed between existing preventive and rehabilitative programs and possibilities for similar interventions aimed at preventing, reversing, or halting declines in physical function in cancer survivors. Finally, a program of research is proposed to evaluate whether there is some subset of breast cancer survivors for whom prevention or rehabilitation of functional status declines is needed, as well as development of targeted, mechanistically driven interventions. (Cancer Epidemiol Biomarkers Prev 2007;16(5):866–72)
Results of European post-marketing surveillance of bosentan in pulmonary hypertension
Authors: Humbert M. , Segal E. S. , Kiely D. G. , Carlsen J. , Schwierin B. , Hoeper M. M. 
Published: May 2007

After the approval of bosentan for the treatment of pulmonary arterial hypertension (PAH), European authorities required the introduction of a post-marketing surveillance system (PMS) to obtain further data on its safety profile.A novel, prospective, internet-based PMS was designed, which solicited reports on elevated aminotransferases, medical reasons for bosentan discontinuation and other serious adverse events requiring hospitalisation. Data captured included demographics, PAH aetiology, baseline functional status and concomitant PAH-specific medications. Safety signals captured included death, hospitalisation, serious adverse events, unexpected adverse events and elevated aminotransferases.Within 30 months, 4,994 patients were included, representing 79% of patients receiving bosentan in Europe. In total, 4,623 patients were naïve to treatment; of these, 352 had elevated aminotransferases, corresponding to a crude incidence of 7.6% and an annual rate of 10.1%. Bosentan was discontinued due to elevated aminotransferases in 150 (3.2%) bosentan-naïve patients. Safety results were consistent across subgroups and aetiologies.The novel post-marketing surveillance captured targeted safety data (“potential safety signals”) from the majority of patients and confirmed that the incidence and severity of elevated aminotransferase levels in clinical practice was similar to that reported in clinical trials. These data complement those from randomised controlled clinical trials and provide important additional information on the safety profile of bosentan.
Neuropsychological patterns in systemic lupus erythematosus patients with depression
Authors: Kozora Elizabeth , Arciniegas David B , Zhang Lening , West Sterling 
Published: May 2007

AbstractThirteen patients with systemic lupus erythematosus and depression (Depressed-SLE), 10 Depressed-Control subjects, and 25 Healthy Control subjects completed cognitive testing and self-report questionnaires of pain, depression, and fatigue. The Depressed-SLE group scored higher on the American College of Rheumatology Neuropsychological Battery for systemic lupus erythematosus cognitive impairment index compared to Depressed-Control and Healthy Control subjects (p < 0.05 and p < 0.02, respectively). No correlations between cognitive impairment and pain, fatigue, or perceived cognitive failures were observed in the Depressed-SLE participants. Moderate agreement (86.4%) was found between a comprehensive neuropsychology battery cognitive impairment index and the ACR-SLE impairment index in the Depressed-SLE patients. Overall, the magnitude and pattern of cognitive impairment in Depressed-SLE patients cannot be explained by depression alone.
Acute and long-term survival in chronically critically ill surgical patients: a retrospective observational study
Authors: Hartl Wolfgang H , Wolf Hilde , Schneider Christian P , Küchenhoff Helmut , Jauch Karl-Walter 
Published: May 2007

Abstract
Introduction
Various cohort studies have shown that acute (short-term) mortality rates in unselected critically ill patients may have improved during the past 15 years. Whether these benefits also affect acute and long-term prognosis in chronically critically ill patients is unclear, as are determinants relevant to prognosis.

Methods
We conducted a retrospective analysis of data collected from March 1993 to February 2005. A cohort of 390 consecutive surgical patients requiring intensive care therapy for more than 28 days was analyzed.

Results
The intensive care unit (ICU) survival rate was 53.6%. Survival rates at one, three and five years were 61.8%, 44.7% and 37.0% among ICU survivors. After adjustment for relevant covariates, acute and long-term survival rates did not differ significantly between 1993 to 1999 and 1999 to 2005 intervals. Acute prognosis was determined by disease severity during ICU stay and by primary diagnosis. However, only the latter was independently associated with long-term prognosis. Advanced age was an independent prognostic determinant of poor short-term and long-term survival.

Conclusion
Acute and long-term prognosis in chronically critically ill surgical patients has remained unchanged throughout the past 12 years. After successful surgical intervention and intensive care, long-term outcome is reasonably good and is mainly determined by age and underlying disease.
A distance difference matrix approach to identifying transcription factors that regulate differential gene expression
Authors: De Bleser Pieter , Hooghe Bart , Vlieghe Dominique , van Roy Frans 
Published: May 2007

AbstractWe introduce a method that considers target genes of a transcription factor, and searches for transcription factor binding sites (TFBSs) of secondary factors responsible for differential responses among these targets. Based on the distance difference matrix concept, the method simultaneously integrates statistical overrepresentation and co-occurrence of TFBSs. Our approach is validated on datasets of differentially regulated human genes and is shown to be highly effective in detecting TFBSs responsible for the observed differential gene expression.
The Catechol-O-Methyltransferase Met158 Low-Activity Allele and Association with Nonvertebral Fracture Risk in Elderly Men
Authors: Stolk Lisette , van Meurs Joyce B. J. , Jhamai Mila , Arp Pascal P. , van Leeuwen Johannes P. T. , Hofman Albert , de Jong Frank H. , Pols Huibert A. P. , Uitterlinden André G. 
Published: May 2007

AbstractContext: Because sex steroids play an important role in bone development, variants in genes encoding proteins involved in estrogen synthesis and metabolism could contribute to interindividual variation in bone parameters and fracture risk. An example is catechol-O-methyltransferase (COMT), an estrogen-degrading enzyme involved in inactivation of catechol-estrogens. Its gene contains a functional valine to methionine substitution at codon 158.Objective: The aim of our study was to determine whether this polymorphism is associated with bone parameters and fracture risk in elderly subjects.Methods: COMT genotypes were determined using TaqMan allelic discrimination in 2515 men and 3554 women from the Rotterdam Study, a population-based cohort study of individuals aged 55 and older. Associations with bone mineral density (BMD) and bone loss were analyzed using ANOVA or analysis of covariance, whereas fracture risk was analyzed using Cox’s proportional hazard regression analysis. COMT mRNA expression in three osteoblastic cell lines (SaOS, MG63, and SVHFO) was analyzed by RT-PCR.Results: Male carriers of the Met158 allele had an increased risk for osteoporotic fractures (hazard ratio = 1.6; 95% confidence interval, 1.0–2.4) and for fragility fractures (hazard ratio = 2.7; 95% confidence interval, 1.3–5.9), with evidence for a dominant effect. Adjustments for age, height, weight, and BMD did not change the risk estimates. In women, this association was weaker and not significant. BMD was not significantly associated with the variant in either men or women. COMT mRNA was expressed in all three osteoblastic cell lines tested.Conclusion: The COMT Val158Met polymorphism is associated with fracture risk in elderly men, through a mechanism independent of BMD.
Metformin Suppresses Interleukin (IL)-1β-Induced IL-8 Production, Aromatase Activation, and Proliferation of Endometriotic Stromal Cells
Authors: Takemura Yuri , Osuga Yutaka , Yoshino Osamu , Hasegawa Akiko , Hirata Tetsuya , Hirota Yasushi , Nose Emi , Morimoto Chieko , Harada Miyuki , Koga Kaori , Tajima Toshiki , Yano Tetsu , Taketani Yuji 
Published: May 2007

Abstract
Context: Metformin, a widely used treatment for diabetes that improves insulin sensitivity, also has both antiinflammatory properties and a modulatory effect on ovarian steroid production, two actions that have been suggested to be efficacious in therapy for endometriosis.
Objective: To determine whether metformin may be effective for the treatment of endometriosis, we evaluated the effects of this agent on inflammatory response, estradiol production, and proliferation of endometriotic stromal cells (ESCs).
Design: ESCs derived from ovarian endometriomas were cultured with various concentrations of metformin.
Main Outcome Measures: IL-8 production, mRNA expression and aromatase activity, and 5-bromo-2′-deoxyuridine incorporation in ESCs were measured.
Results: Metformin dose-dependently suppressed IL-1β-induced IL-8 production, cAMP-induced mRNA expression and aromatase activity, and 5-bromo-2′-deoxyuridine incorporation in ESCs.
Conclusion: These results suggest that further investigation into the unique therapeutic potential of metformin as an antiendometriotic drug is warranted.
Genomic Checkpoints for Exon 10 Usage in the Luteinizing Hormone Receptor Type 1 and Type 2
Authors: Gromoll Jörg , Lahrmann Lisa , Godmann Maren , Müller Thomas , Michel Caroline , Stamm Stefan , Simoni Manuela 
Published: May 2007

AbstractAlternative splicing is a hallmark of glycoprotein hormone receptor gene regulation, but its molecular mechanism is unknown. The LH receptor (LHR) gene possesses 11 exons, but exon 10 is constitutively skipped in the New World monkey lineage (LHR type 2), whereas it is constitutively spliced in the human (LHR type 1). This study identifies the regulatory elements of exon 10 usage. Sequencing of genomic marmoset DNA revealed that the cryptic LHR exon 10 is highly homologous to exon 10 from other species and displays intact splice sites. Functional studies using a minigene approach excluded the contribution of intronic, marmoset-specific long interspersed nucleotide-1 elements to exon 10 skipping. Sequencing of the genomic regions surrounding exon 10 from several primate lineages, sequence comparisons including the human and mouse LHR gene, revealed the presence of unique nucleotides at 3′-intronic position −19 and −10 and at position +26 within exon 10 of the marmoset LHR. Exon trap experiments and in vitro mutagenesis of these nucleotides resulted in the identification of a composite regulatory element of splicing consisting of cis-acting elements represented by two polypyrimidine tracts and a trans-acting element within exon 10, which affect the secondary RNA structure. Changes within this complex resulted either in constitutive exon inclusion, constitutive skipping, or alternative splicing of exon 10. This work delineates the molecular pathway leading to intronization of exon 10 in the LHR type 2 and reveals, for the first time, the essential function of regulatory and structural elements involved in glycoprotein hormone receptor splicing.
Dialectic Behaviour Therapy: A 12-Month Collaborative Program in a Local Community Setting
Authors: Prendergast Nicole , McCausland Jean 
Published: May 2007

AbstractThis study focuses on examining the efficacy of dialectic behaviour therapy (DBT) on female clients who meet the criteria of borderline personality disorder (BPD) within a community setting. A clinical sample of 11 women with BPD was provided with a 6-month DBT program that was collaboratively developed and delivered by Logan Women's Health service and Logan Central Adult Mental Health. Results indicate that DBT is an effective treatment for parasuicidal behaviour and decreased the frequency of medically severe suicide attempts. In addition, the duration of telephone contact, face-to-face contact and number and duration of hospital admissions decreased during the DBT program. The participants' psychological, social and occupational functioning improved. Of significance, depression levels also decreased on completion of the program. Future studies would benefit from a larger sample and a control group. This study demonstrates that DBT is an effective treatment for BPD clients within an Australian community setting and has many clinical benefits.
Changes in Functional Behaviour of Adults With Brain Injury and Spouse-Caregiver Burden With In-Home Neurobehavioural Intervention
Authors: Palmisano Barbara , Arco Lucius 
Published: May 2007

AbstractA within-participant multiple baseline experiment evaluated effects of in-home neurobehavioural interventions on functional behaviour of 3 persons with brain injury, and their spouses' burden of care. The 6-week individualised interventions included in-home and telephone consultations. Measures consisted of functional behaviour of the injured persons, spouses' burden of care using the QRS-SF at preand postintervention and at 1 month follow-up, and social validity. Results show interventions were efficacious in improving functional behaviour, but effects on burden of care and social validity were mixed. One caregiver who presented with high levels of burden at preintervention reported reduced burden, while the other 2 who presented with low to moderate burden reported no changes.
Reinnervation of Late Postnatal Purkinje Cells by Climbing Fibers: Neosynaptogenesis without Transient Multi-Innervation
Authors: Letellier Mathieu , Bailly Yannick , Demais Valérie , Sherrard Rachel M. , Mariani Jean , Lohof Ann M. 
Published: May 2007

Synaptic partner selection and refinement of projections are important in the development of precise and functional neuronal connections. We investigated the formation of new synaptic connections in a relatively mature system to test whether developmental events can be recapitulated at later stages (i.e., after the mature synaptic organization has been established), using a model of postlesional reinnervation in the olivo-cerebellar pathway.During the development of this pathway, synaptic connections between climbing fibers (CFs) and Purkinje cells (PCs) are diffuse and redundant before synapse elimination refines the pattern. The regression of CFs during the first 2 postnatal weeks in the rat leads to mono-innervation of each PC. After unilateral transection of the rat olivo-cerebellar pathway and intracerebellar injection of BDNF 24 h after lesion, axons from the remaining inferior olive can sprout into the deafferented hemicerebellum and establish new contacts with denervated PCs at later developmental stages. We found that these contacts are first established on somatic thorns before the CFs translocate to the PC dendrites, recapitulating the morphological steps of normal CF–PC synaptogenesis, but on a relatively mature PC.However, electrophysiology of PC reinnervation by transcommissural CFs in these animals showed that each PC is reinnervated by only one CF. This mono-innervation contrasts with the reinnervation of grafted immature PCs in the same cerebellum. Our results provide evidence that relatively mature PCs do not receive several olivary afferents during late reinnervation, suggesting a critical role of the target cell state in the control of CF–PC synaptogenesis. Thus, synapse exuberance and subsequent elimination are not a prerequisite to reach a mature relationship between synaptic partners.
Stephen Weber Long. Caring for People with Challenging Behaviors: Essential Skills and Successful Strategies in Long-Term Care. Baltimore, MD: Health Professions Press, 2005.
Authors: Wilson Donna 
Published: May 2007

RÉSUMÉCaring for People with Challenging Behaviors: Essential Skills and Successful Strategies in Long-Term Carerenferme de l'information éminemment utile pour quiconque dispense des soins à des personnes présentant des comportements difficiles. Quoique les prestataires de soins puissent être aux prises avec de telles personnes dans d'autres milieux de soins, le DrLong précise que c'est le cas de 80 pour cent des résidents en établissement de soins de longue durée, et que ces comportements sont pour beaucoup le principal motif d'admission dans l'établissement. L'ouvrage se révèle un guide précieux dans le relevé des causes internes ou externes des comportements problématiques et dans la détermination des moyens de prévenir ou de prendre en charge ces comportements.
The Functional Transitions Model: Maximizing Ability in the Context of Progressive Disability Associated with Alzheimer's Disease
Authors: Slaughter Susan , Bankes Jane 
Published: May 2007

ABSTRACTThe Functional Transitions Model (FTM) integrates the theoretical notions of progressive functional decline associated with Alzheimer's disease (AD), excess disability, and transitions occurring intermittently along the trajectory of functional decline. Application of the Functional Transitions Model to clinical practice encompasses the paradox of attempting to minimize excess disability while anticipating the progressive functional decline associated with AD. It is suggested that times of functional transition are times of decision making and opportunities for interdisciplinary collaboration to identify and minimize excess disability, for revision of goals and expectations, and for provision of support to patients and caregivers. The model also is applicable as a conceptual framework for education and research.
CsAl(H2AsO4)2(HAsO4): A New Monoclinic Protonated Arsenate with Decorated Kroehnkite‐Like Chains.
Authors: Schwendtner Karolina , Kolitsch Uwe 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Competing Hydrogen‐Bond Acceptors in Ethylenediammonium Oxotrithiotungstate(VI).
Authors: Srinivasa Bikshandarkoil R. , Naik Ashish R. , Naether Christian , Bensch Wolfgang 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Phase Diagram of the TbBr3—RbBr Binary System: Thermodynamic and Transport Properties of the Rb3TbBr6 Compound.
Authors: Rycerz Leszek , Gaune‐Escard Marcelle 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Rare‐Earth Metal‐Rich Antimonides: Syntheses, Structures, and Properties of Tm3Sb and Lu7Sb3.
Authors: Gupta Shalabh , Chen Ling , Ganguli Ashok K. , Corbett John D. 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.