bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of a Modified Dummy Gas Lift Valve for Subsurface Depth-Resolved Microbiological Sampling and 3D Mapping
Authors: McElhinney J. M. W. R. , Gomes J. S. , Hasan A. , Dias J. 
Published: March 2024

Objectives/Scope
This study outlines the development and use of a modified dummy gas lift valve designed to obtain subsurface microbiological samples from a defined depth series across a production well. An overview of the initial field pilot is presented wherein microbiological data from the modified valve will be contrasted with topside samples to evaluate the information yielded from sampling downhole biofilm communities in place of planktonic populations from the well head.

Methods, Procedures, Process
In this approach, the modified dummy gas lift valve, preloaded topside with carbonate plugs and coupons, is deployed at various depths in the well's completion for downhole incubation. This modification allows production fluids to wet the payloads, enabling in situ biofilm colonization by reservoir communities across depth and temperature gradients. Post retrieval using a slickline tool, sample DNA is extracted for metagenomic sequencing, assessing microbial composition and metabolic capabilities (including souring and MIC-related activities). Concurrent production fluid samples from the wellhead will be analyzed for comparison to evaluate any information gained from biofilm over planktonic population sampling.

Results, Observations, Conclusions
Samples from the modified valve are expected to provide sufficient yields of DNA, uncontaminated by non-resident microbes from outside of the producer. Microbial data from downhole biofilms is anticipated to provide a more diverse community makeup than production fluid communities sampled at the wellhead, with a corresponding increase in problematic species associated with MIC and souring. Corrosion coupon analyses will enable conclusions regarding proactive decision-making enablement and extrapolations of 3D projections of microbiological communities between modified valves across the completion column will provide the relationship between in situ conditions, microbial colonization in the context of pore space and risks of unfavourable microbiological activities with potential correlations to known zones of souring and corrosion. Understanding these microbial profiles can directly inform targeted interventions in reservoir management for more efficient and sustainable operations.

Novel/Additive Information
This paper presents a novel approach to in situ microbiological sampling at specific reservoir depths, a procedure not commonly practiced due to significant constraints associated with existing subsurface sampling approaches (such as side wall coring and core drilling operations). The resulting data can provide valuable insights for practicing engineers into the actual communities residing downhole and spatial microbiological heterogeneity of reservoirs, enabling more accurate proactive assessment for reservoir water management and maintenance.
Framework for Optimal Waterflood Design: Guiding the Right Choice – Part I
Authors: Khan M. N. , Dada A. , Maire F. 
Published: March 2024

AbstractThis abstract encapsulates the essence of a series of technical papers dedicated to optimizing waterflooding operations in the petroleum industry. These papers collectively represent a comprehensive guide, addressing the multifaceted dimensions of waterflooding from planning to execution and monitoring, with a focus on enhancing production efficiency while minimizing environmental impacts. This first paper, a key part of the series, offers an in-depth analysis of the waterflood development framework for various types of reservoirs, both offshore and onshore, highlighting the adaptability required for different geological contexts such as carbonate and sandstone fields.The methodology employed in this paper reflects a holistic approach, encompasses a systematic evaluation of waterflood performance across four main factors: reservoir characteristics, water quality, injection and production strategies, and surface facilities. This evaluation strives to integrate advanced technologies and methodologies with the environmental considerations, regulatory compliance, and the diverse technical and operational challenges encountered in waterflooding projects. The associated risks and challenges underscore the complexity and dynamism of waterflooding, emphasizing the need for comprehensive reservoir characterization, appropriate water quality control, flexible strategy adaptation, and robust surface infrastructure.This paper aims to provide appropriate integrated details and evaluation of waterflood development and performance. It provides a valuable resource for the petroleum industry, guiding professionals and researchers in designing and optimizing waterflood projects. By presenting practical, technologically advanced solutions, this paper contributes to the advancement of waterflood technology, the enhancement of oil recovery processes, and the economic and environmental sustainability of waterflood operations. As part of a dynamic series, it reflects the evolving nature of industry practices and technological advancements, aiming to guide strategic, efficient, and profitable waterflood management in oil recovery.
Unlocking Value: Comparative Well Study Shows Energy and Cost Savings via Reduction in Water and Gain in Oil Using Autonomous Inflow Control Valve (AICV) in a Major Brownfield in The Sultanate of Oman
Authors: Al Lawati A. H. , Al Harthi M. , Al Riyami S. , Al Kindi R. , Baqer A. , Al Araimi Y. , Ismail I. M. , Fahmy A. 
Published: March 2024

Abstract
Fields in the South of Oman house a variety of complexities ranging from geological to operational. Three sandstones reservoirs exist, each with their own properties and recovery mechanisms; however, the commonality they share is the issues with water production. Dozens of wells have been completed in this field, but non-uniform fluid influx causes wells to produce over nine barrels of water to around one barrel of oil. This goes without saying the requirements to handle the water, which are large and costly. The effects of these are also found in CO2 emissions, which continue to be a detriment to not only the environment but the industry. Therefore, the need for technology to combat these issues is critical. As a result, the operator decided to complete wells with the Autonomous Inflow Control Valve (AICV).
The valve is designed to shut off for unwanted fluid, like water, and open for oil, unlocking the avenue to sustainable production and cost-effectiveness. The AICV can detect the fluid flowing through it via its properties like density and viscosity and react based on its mechanical properties. This paper will describe this in detail, along with explanations of the AICV completion and flow characteristics.
As the fields were drilled by the operator and completed with and without AICVs, there was a difference in performance, which meant different results. Therefore, a study was conducted to quantify them and compare between AICV and nearby wells, offering valuable insights. From 2019 to 2023, comparing between 79 AICV wells and 100 nearby, wire-wrap screen (WWS) wells, AICV wells, on average, have demonstrated an increase in oil by two-fold and a decrease in water by 42% compared to nearby wells. This gain in oil meant higher revenue, which was also more than double. The reduction in water meant less CO2 emissions by 71%, energy output by 42% and cost by 28%.
The results are positive indications towards industry and environment, aiding in the commitments towards tackling water issues while ensuring sustainable and green operations. This field-proven technology has shown that in brownfields with aging reservoirs, untapped oil can be produced, increasing recovery while elongating well life.
Response Strategies of Five Common Warm Temperate Species to Insect Defoliation
Authors: Wang Ning , Li Qiang , Wu Pan , Yi Shijie , Wen Xuehong , Liu Xiao 
Published: March 2024

Abstract

Under the background of global climate change, the insect herbivory phenomenon has been frequent, which significantly affects the growth, survival, and regeneration of forest plants in the warm temperate zone of China. Plants can adopt defense responses to adapt to insect defoliation. Therefore, field experiments were conducted on five common warm temperate species, Quercus acutissima, Quercus serrata, Quercus aliena, Quercus dentata, and Robinia pseudoacacia. We measured the leaf traits of healthy trees and insect defoliated trees, to explore the response strategies of common species in warm temperate zones to insect defoliation. Our results showed that native species stored more carbon in extreme environments for survival rather than growth, while alien species tended to adopt active resource acquisition strategies and were more inclined towards growth. Then the content of tannins and flavonoids in the alien species R. pseudoacacia did not significantly increase after leaf damage, while the content of secondary metabolites such as tannins, flavonoids, and total phenols in the native species Q. acutissima, Q. serrata, Q. aliena, Q. dentata increased significantly after leaf damage. This indicated that compared to alien species, native species would invest more resources in defense, which might reduce resource allocation for growth. Thus, the native Quercus species have stronger resistance than the alien species R. pseudoacacia after insect defoliation.
Improving generalizability and data efficiency for MHC-I binding peptide predictions through structure-based geometric deep learning
Authors: Xue Li , Marzella Dario , Crocioni Giulia , Radusinović Tadija , Lepikhov Daniil , Severin Heleen , Bodor Dani , Rademaker Daniel , Lin ChiaYu , Georgievska Sonja , Renaud Nicolas , Kessler Amy , Lopez-Tarifa Pablo , Buschow Sonja , Bekkers Erik 
Published: March 2024

Abstract

The interaction between peptides and major histocompatibility complex (MHC) molecules is pivotal for tissue transplantation, pathogen recognition and autoimmune disease treatments. Recent advances in cancer immunotherapies demand for more accurate computational prediction of MHC-bound peptides. We address the generalizability challenge of MHC-bound peptide predictions, revealing limitations in current sequence-based approaches. Our solution employs structure-based methods leveraging geometric deep learning (GDL), yielding up to 8% improvement in generalizability across unseen MHC alleles. We tackle data efficiency by introducing a self-supervised learning approach surpassing sequence-based methods, even without being trained on binding affinity data. Finally, we demonstrate the resilience of structure-based GDL methods to biases in binding data on an Hepatitis B virus vaccine design case study. This study highlights structure-based methods’ potential to enhance generalizability and data efficiency, with implications for data-intensive fields like T-cell receptor specificity predictions, paving the way for enhanced comprehension and manipulation of immune responses.
Atomic-scale insights into topotactic transformations in extra-large pore silicate zeolites using time-resolved 3D electron diffraction
Authors: Zou Xiaodong , Luo Yi , Xu Hao , Han Yue , Tong Wen , Jiao Meichen , Wang Naihong , Jiang Jingang , Wu Peng 
Published: March 2024

Abstract

Understanding the atomic scale structural dynamics of phase transformations is crucial for developing new materials and tailoring the properties of the materials. However, many materials are obtained as polycrystalline powders with large unit cells and/or complex structures, making it challenging to investigate detailed structural changes using conventional X-ray diffraction techniques. Here, we employ time-resolved 3D electron diffraction (3D ED) to unravel the topotactic reactions and transformations of extra-large pore silicate zeolites ECNU-45 to ECNU-46. Notably, ECNU-45 features 3D interconnecting 24×10×10-ring channels, while ECNU-46 exhibits 1D 24-ring channels connected to 10-ring pockets. ECNU-45 and ECNU-46 are the first reported examples of pure silicate zeolites with pores larger than 22-rings. Our findings showcase detailed changes at six distinct tetrahedral Si sites, involving atom displacement, addition, and removal of framework atoms through bond breakage and formation. This work not only presents the discovery of novel zeolites but also provides unprecedented atomic-level insights into the dynamic processes of topotactic reactions. Our results have significant implications for advancing materials engineering and understanding complex solid-state reactions at an atomic scale.
Psychological Impact of the earthquake 2023 in Turkey
Authors: Kizilhan Jan Ilhan , Neumann Johanna , Aslan Siyabend , Aladag Erdal , Dogan Abdulsamet , Mese Abdullativ , Bekisoglu Ahmet , Wenzel Thomas 
Published: March 2024

Abstract

Background
The Turkish and Syrian earthquake on February 6th 2023 was the deadliest earthquakes in the last decade. It affected approximately 26 million people and left at least 50.000 dead. In this paper, we analyzed the psychological impact and the relationship between mental health factors, earthquake related experiences and stressors and resources related to the earthquake, four months after the event
Methods
We conducted an analytical cross-sectional study, applying a survey to 320 adults (1–93 years old) in Adiyaman, Turkey. PTSD-Symptoms, general psychiatric morbidity, suicidality and drug abuse, as well as post traumatic growth were assessed via the PC-PTSD, GHQ-12 together with questions focusing on the earthquake experience, related stressors and support received.
Results
We found a high prevalence of general mental health symptoms including those of PTSD. Fear of aftershocks and the loss of close family members were found to be risk factors for such symptoms. We didn’t find significant differences in the GHQ or the PTSD symptom scores when considering ethnicity, religion or income.
Conclusions
High levels of psychiatric stress and PTSD symptoms were found four months after the earthquake, as could be expected, and need to be addressed in all groups independent from religious, social or ethnic background. Results indicate a large psychiatric and material burden on the entire sample and indicated some priority needs.
A Revisit on Lead in Decorative and Industrial Paints in Nigeria
Authors: Akindele Ajoke Fehintola Idayat , Osibanjo Oladele 
Published: March 2024

Abstract

No thanks to the injurious levels of lead in paints reported in the past. This study seeks to revisit the concentrations of lead in paints from different sectors, brand and types in the Nigerian markets. The study was investigated to check the marketed paints for improved and healthy formulation. The analysis showed Pb levels (µg/g in dry weight) in the samples across different manufacturers ranged from 2,220 − 91,500 in a cream (water-based) and black (oil-based) coloured decorative paints. The levels of Pb in oil-based paint ranged from 4,490 − 91,500 with mean of 38100 and 2,220 − 91,500 with mean of 21,800 in water-based paints. The Pb level in the paint samples is 50 times the 600 µg/g and 500 fold the 90 µg/g recommended by the US EPA and CPSC for paints. The main Principal Component Analysis accounted for upto 70% indicating that lead compounds, are majorly used as pigment to improve the quality of paints by paint manufacturers. Lead, has continuously been reported for its toxicity and no safe levels for children. This study is so revealing. Therefore, there is a major challenge to abate lead in all paint sectors by the government and this, should be done in good time.
Acceptability and effectiveness of empathy-based provider training and community-level awareness activities on self-injectable contraceptive use in Niger, Lagos, and Oyo States, Nigeria: A mixed methods program evaluation
Authors: Ontiri Susan , Rothschild Claire W. , Tariq Fauzia , Adeleke Oluwaseun , Titus Michael , Raji Mopelola , Njogu Julius , Gibbs Susannah , Swearingen Robin , Edet Fidelis 
Published: March 2024

Abstract

Background: Interventions aimed to increase healthcare provider empathy and capacity to deliver person-centered care have been shown to improve healthcare seeking and outcomes. In the context of self-injectable contraceptive service delivery, empathetic counseling and hands-on coaching are promising approaches for addressing “fear of the needle” among clients interested in using subcutaneous depot medroxyprogesterone (DMPA-SC). In Nigeria, the Delivering Innovation for Self-Care (DISC) project developed and evaluated an empathy-based in-service training and supportive supervision intervention for public sector family planning providers, which was implemented in conjunction with community-based sensitization.
Methods: The DISC intervention was evaluated using a quasi-experimental mixed methods design. Effectiveness of the intervention on DMPA-SC service delivery, including DMPA-SC self-injection (SI) and provider administration (PA), was assessed using a single-group interrupted time series design that leveraged phased implementation in 36 study facilities. Service delivery data were extracted from the Nigerian Health Information System for the pre-intervention period and using program monitoring tools for the intervention and post-intervention maintenance period. Outcomes were modeled using linear generalized estimating equations. In-depth interviews were conducted with trained providers.
Results: Mean DMPA-SC service provision increased by 28 (95% confidence interval [CI] 18.0-38.3) visits on average per facility in the first month of implementation, relative to a pre-intervention data strengthening phase. The intervention was associated with an increase in mean facility-level DMPA-SC SI service delivery of 25.6 visits (95% CI 15.3-35.4). The intervention was associated with overall increases in FP service delivery. Trained providers reported substantial increases in client demand for DMPA-SC SI, coupled by increased provider feelings of confidence and capacity to counsel and train clients to self-inject. While providers indicated that stockouts of intramuscular DMPA (DMPA-IM) resulted in shifts towards DMPA-SC, we did not observe group-level decreases in DMPA-IM or long-acting reversible contraception provision. Increases in DMPA-SC service provision were sustained in the post-intervention maintenance period.
Discussion: Our findings demonstrate the effectiveness and acceptability of project implementing combined supply-and demand-side interventions aimed at expanding awareness and access to self-injectable contraception in Nigeria. In this context, family planning providers highly valued in-service training and ongoing support that built capacity for empathetic client engagement.
Testing support models for implementing an evidence-based digital intervention for alcohol use disorder: results of a pragmatic hybrid implementation-effectiveness trial
Authors: Quanbeck Andrew , Chih Ming-Yuan , Park Linda , Li Xiang , Xie Qiang , Pulvermacher Alice , Voelker Samantha , Lundwall Rachel , Eby Katherine , Barrett Bruce , Brown Randy 
Published: March 2024

Abstract

This paper reports results of a hybrid effectiveness-implementation randomized trial that systematically varied levels of human oversight required to support implementation of a digital medicine intervention for persons with mild to moderate alcohol use disorder (AUD). Participants were randomly assigned to three groups representing possible digital health support models within a health system: self-monitored use (n = 185), peer-supported use (n = 186), or a clinically integrated model (n = 187). Across all three groups, percentage of risky drinking days dropped from 38.4% at baseline (95%CI [35.8%, 41%]) to 22.5% (19.5%, 25.5%) at 12 months. The clinically integrated group showed significant improvements in mental health quality of life compared to the self-monitoring group (p = 0.011). However, higher rates of attrition in the clinically integrated group warrants consideration in interpreting this result. Results suggest that making a self-guided digital intervention available to patients may be a viable option for health systems looking to promote alcohol risk reduction.
A Novel Role for Lupeol in Hepatocellular Carcinoma Treatment via Promoting Autophagy to Suppress Exosome Secretion
Authors: CHEN Kehan , ZHANG Xin , LIU Xiang , GAO Zhan-Wang , ZHAO Yu , LU Shu-Ru , LIAO Dai-yuan , LIU Wen , WANG Jian-Song , WANG Lingli 
Published: March 2024

Abstract

Malignant hepatocellular carcinomas (HCC) are among the most lethal malignancies globally, posing a significant challenge for treatment due to the scarcity of viable therapeutic interventions. This study aims to explore the potential anti-tumor properties of lupeol, a naturally occurring triterpenoid found in diverse vegetables, fruits, and herbs. Initially, it was discovered that lupeol demonstrates significant in vitro anti-proliferative and anti-metastatic properties. Furthermore, the presence of lupeol resulted in a decrease in exosome levels, while the restoration of exosome levels subsequently led to the resµMption of cell proliferation and migration capabilities. In addition, the investigation of intrinsic mechanisms demonstrated that lupeol may inhibit exosome levels by inducing autophagy, while investigation of intrinsic mechanisms has demonstrated that lupeol may inhibit exosome levels by inducing autophagy. The current investigation elucidated the anti- HCC mechanism of lupeol, thereby proposing its potential as an alternative therapeutic approach or dietary supplement for HCC. Additionally, this study offers novel perspectives on the importance of autophagy and exosome involvement in HCC progression.
Lymphatic Markers in Kaposiform Hemangioendothelioma: Implications for Tumor Invasiveness and β-blockers efficacy
Authors: Yu Lu , Wei Li , Qiu Lei , Ma Lin , Li Li 
Published: March 2024

Abstract

Background: Kaposiform hemangioendothelioma (KHE) is a rare vascular tumor that usually expresses lymphatic markers. PROX1 can increase the local invasiveness of KHE in mice.
Objectives: To evaluate whether the expression of lymphatic markers in KHE patients increases their invasiveness and decreases the efficacy of β-blockers (propranolol or atenolol).
Methods: The tumor tissues of 3 patients with KHE were collected for transcriptomics. The clinical data of 15 patients were collected to analyze the correlation between PROX1, invasiveness and β-blockers’ efficacy. Overexpression PROX1 in EOMAs, cell viability assay, apoptosis, cell cycle, migration, and β-blockers’ efficacy were analyzed in vitro. Tumor invasiveness was analyzed in vivo.
Results: PROX1 might increase local invasiveness of the KHE due to impact cell motility, locomotion, and migration. The nearly complete resolution rate (>75%) of β-blockers (propranolol or atenolol) in the treatment of KHE was 40 %. There was no significant correlation between the positive rate of PROX1 and the efficacy of β-blockers’ treatment.
Limitations: Due to small numbers, the effect of PROX1 on the efficacy of propranolol needs further study.
Conclusion: Our study showed the higher positive rate of PROX1 in the tumor, the more prone the local invasiveness of the KHE patients. There was no significant correlation between the positive rate of PROX1 and the efficacy of 10 patients with β-blockers treatment.