bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGARUH RETURN ON ASSET DAN EARNING PER SHARE TERHADAP PT. CHAROEN POKPHAND INDONESIA Tbk. PERIODE 2010 - 2020
Authors: Yasin Fadli Achmad Agus , Bahari Fajar 
Published: April 2024

ABSTRAK Penelitian ini bertujuan untuk menjelaskan pengaruh Return On Asset sebagai Fariabel bebas X1. dan Earning Per Share sebagai variabel bebas X2 terhadap harga saham sebagai variabel terikat Y. Populasi dalam penelitian ini yaitu laporan keuangan PT Charoen pokphand Indonesia Tbk. dan sampel yang digunakan adalah laporan kas dan laporan laba rugi. Periode 2010 sampai 2021. Jenis Penelitian ini menggunakan metode pengujian hipotesis, dengan teknik statistik yang bersifat kuantitatif deskriptif. Alat analisis yang digunakan adalah regresi linear berganda menggunakan program Statistical Package for the Social Sciences version 21. Hasil uji t parsial menunjukan bahwa Return On Asset berpengaruh positif signifikan terhadap Harga Saham, sedangkan pada variabel Earning Per Share terdapat pengaruh yang signfikan terhadap Harga Saham. Berdasarkan hasil uji f (secara simultan) menunjukan bahwa terdapat pengaruh yang signifikan antara variabel Return On Asset dan Earning Per Share terhadap Harga Saham. Kata Kunci: Return On Asset; Earning Per Share; Harga SahamABSTRAKThis study aims to explain the effect of Return On Asset as the independent variable (X1), and Earning Per Share as the independent variable (X2) on the stock price as the dependent variable (Y). The population in this study were all financial statements of PT Charoen Pokphand Indonesia Tbk. and the samples used are the Consolidated Balance Sheet and Profit and Loss Statements for the period 2010 to 2021. This type of research uses the hypothesis testing method, with statistical techniques that are quantitative descriptive. The analysis tool used is multiple linear regression using the Statistical Package for the Social Sciences program version 21. Based on the results of the t test partial, it shows that the Return On Asset has a significant positive effect on stock prices, while the Earning Per Share variable does not have a significant effect on stock prices. Based on the results of the f test (simultaneously), it shows that there is a significant influence between the variable Return On Asset and Earning Per Share on Stock Prices. Keyword: Return On Asset; Earning Per Share; Harga Saham
ANALISIS BRAND EQUITY PRODUK TEH BOTOL SOSRO BERDASARKAN BRAND ASSOCIATION
Authors: Andriani Ria , Yuniasih Idah 
Published: April 2024

ABSTRAK Penelitian ini bertujuan untuk mengetahui nilai tambah dari suatu merek Teh Botol Sosro dengan menggunakan elemen Brand Association. Metode penelitian yang digunakan dalam penelitian adalah kuantitatif dengan jumlah sampel sebanyak 60 responden dengan metode pengambilan sampel purposive sampling. Analisis data yang digunakan peneliti menggunakan uji Cochranâ€™s Q dengan pengolah data SPSS versi 25. Hasil penelitian menunjukan Brand Association merek Teh Botoh Sosro memiliki asosiasi yang postif dimata konsumen. Hasil statistik yang dilakukan sebanyak 3 tahap pengujian menunjukan H0 diterima dengan nilai statistik sebesar 2,667. Elemen Brand Association yang digunakan adalah Teh Botol Sosro terkenal karena rasanya yang enak dan segar, serta kemasannya yang praktis dan mudah dibawa ke mana-mana (Terkenal), Teh Botol Sosro diproduksi dengan menggunakan bahan-bahan berkualitas dan proses produksi yang aman, sehingga memenuhi standar kesehatan dan keamanan pangan yang diperlukan, sehingga aman untuk dikonsumsi (aman dikonsumsi), ketersediaan Teh Botol Sosro yang luas di pasaran membuat konsumen lebih mudah untuk mendapatkannya (mudah ditemukan) Teh Botol Sosro adalah merek yang terpercaya dan dapat diandalkan sebagai minuman teh botol berkualitas di Indonesia (Terpercaya). Kata-kata Kunci: Brand Equity, Brand Association ABSTRACT This study aims to determine the added value of a brand Teh Botol Sosro by using the Brand Association element. The research method used in this research is quantitative with a total sample of 60 respondents with purposive sampling method. Data analysis used by researchers used the Cochran's Q test with SPSS data processor version 25. The results showed that the Brand Association for the Teh Botoh Sosro brand had positive associations in the eyes of consumers. The statistical results that were carried out in 3 stages of the test showed that H0 was accepted with a statistical value of 2.667. The Brand Association element used is Teh Botol Sosro, known for its delicious and fresh taste, as well as its practical and easy-to-carry packaging (Famous). Teh Botol Sosro is produced using quality ingredients and a safe production process, so that it meets health and food safety standards required, so that it is safe for consumption (safe to consume), the wide availability of Sosro Bottle Tea on the market makes it easier for consumers to obtain it (easy to find) Sosro Bottle Tea is a trusted and reliable brand as a quality bottled tea drink in Indonesia (Trusted). Keywords: Brand Equity, Brand Association
Monitoring of individual indicators of safety and quality of water and fish of Khadzhibey estuary
Authors: Holubenko O. O. , Tarasenko L. O. 
Published: April 2024

Water significantly influences the quality and safety of fish because it is the environment for the life and cultivation of fish. A study of hydrochemical and microbiological indicators of the water of Khadzhibey estuary was conducted; the content of heavy metals in it was determined. In the Khadzhibey estuary, from 2022 to 2023, the water acidity indicator was stable, did not exceed the established hygienic standards for fish farms, and was within the range of 7.6 ± 0.4–8.4 ± 0.3 mg/L, which completely meets the requirements for fish farming. The maximum salinity in the estuary is observed in summer and is 15 % higher compared to winter and spring indicators. The water type of the estuary is mixed with moderate mineralization. It was established that the zinc content in water samples from the estuary exceeds the maximum permissible concentration by 2.6 %. The content of Cadmium, Lead, Copper, and Mercury is constant and does not exceed the maximum allowable concentration for fish farms. An increase in zinc content in water is a stress factor and affects the quality of fish meat. The research results showed that the content of mesophilic aerobic and facultative anaerobic organisms does not exceed the maximum permissible level in muscle tissue cultures of common carp and round bull caught by commercial fishing from the Khadzhibey estuary. Escherichia coli bacteria, Staphylococcus aureus, Listeria monocytogenes, and pathogenic microorganisms were not detected in the samples of the fish subject to the study. According to the microbiological indicators of water and fish, common carp and Round goby caught by industrial fishing in the Khadzhibey estuary are safe and allowed for further consumption by humans and animals.
Return Of Martin Guerre, Teaching History In Images, History In Words
Authors: Voeltz Richard 
Published: April 2024

The Return of Martin Guerre received rave reviews from historians and history teachers when it was first released in this country in 1983. The distinguished Princeton University historian Natalie Zemon Davis had acted as historical consultant to the producers of the film while at the same time researching and writing her book, The Return of Martin Guerre (Cambridge: Harvard University Press, 1983). Critics and historians especially praised the film for its sensitive renderings of daily life in sixteenth-century France, of the mentalité of the period, i.e., how people actually view their world. Therefore, if for no other reason, the film is a significant learning resource for students of history from secondary to upper-level college courses.1 By acquainting students with the concept of mentalités, in this instance common reference points and symbols of an historical era, the entire concept of periodization in history, with its inherent artificiality, becomes a subject of suspicion to inquiring minds. And no era in history needs further reconsideration in terms of periodization than the Renaissance and Reformation.
Development and application of one-step multiplex Real-Time PCR for detection of three main pathogens associated with bovine neonatal diarrhea
Authors: Wang Chaonan , Wang Fang , Chang Jitao , Jiang Zhigang , Han Yuxin , Wang Meixi , Jing Bo , Zhao Aiyun , Yin Xin 
Published: April 2024

IntroductionNeonatal calf diarrhea (NCD) is one of the most common diseases in calves, causing huge economic and productivity losses to the bovine industry worldwide. The main pathogens include bovine rotavirus (BRV), bovine coronavirus (BCoV), and Enterotoxigenic Escherichia coli (ETEC) K99. Since multiple infectious agents can be involved in calf diarrhea, detecting each causative agent by traditional methods is laborious and expensive.MethodsIn this study, we developed a one-step multiplex Real-Time PCR assay to simultaneously detect BRV, BCoV, and E. coli K99+. The assay performance on field samples was evaluated on 1100 rectal swabs of diseased cattle with diarrhea symptoms and compared with the conventional gel-based RT-PCR assay detect BRV, BCoV, and E. coli K99+.ResultsThe established assay could specifically detect the target pathogens without cross-reactivity with other pathogens. A single real-time PCR can detect ~1 copy/µL for each pathogen, and multiplex real-time PCR has a detection limit of 10 copies/µL. Reproducibility as measured by standard deviation and coefficient of variation were desirable. The triple real-time PCR method established in this study was compared with gel-based PT-PCR. Both methods are reasonably consistent, while the real-time PCR assay was more sensitive and could rapidly distinguish these three pathogens in one tube. Analysis of surveillance data showed that BRV and BCoV are major enteric viral pathogens accounting for calves’ diarrhea in China. DiscussionThe established assay has excellent specificity and sensitivity and was suitable for clinical application. The robustness and high-throughput performance of the developed assay make it a powerful tool in diagnostic applications and calf diarrhea research. ​
Cardioprotective effects of high-altitude adaptation in cardiac surgical patients: a retrospective cohort study with propensity score matching
Authors: Lei Li , Liu Mengxue , Ma Die , Lei Xia , Zeng Si , Li Peng , Huang Keli , Lyu Juanjuan , Lei Qian 
Published: April 2024

BackgroundThe cardioprotective effect of remote ischemia preconditioning in clinical studies is inconsistent with experimental results. Adaptation to high-altitude hypoxia has been reported to be cardioprotective in animal experiments. However, the clinical significance of the cardioprotective effect of high-altitude adaptation has not been demonstrated.MethodsA retrospective cohort study with propensity score matching was designed to compare the outcomes of cardiac surgery between highlanders and lowlanders in a tertiary teaching hospital. The data of adult cardiac surgical patients from January 2013 to December 2022, were collected for analysis. Patients with cardiopulmonary bypass and cardioplegia were divided into a low-altitude group (&lt;1,500 m) and a high-altitude group (≥1,500 m) based on the altitude of their place of residence.ResultsOf 3,020 patients, the majority (87.5%) permanently lived in low-altitude regions [495 (435, 688) m], and there were 379 patients (12.5%) in the high-altitude group [2,552 (1,862, 3,478) m]. The 377 highlander patients were matched with lowlander patients at a ratio of 1:1. The high-altitude group exhibited a 44.5% reduction in the incidence of major adverse cardiovascular events (MACEs) compared with the low-altitude group (6.6% vs. 11.9%, P = 0.017). The patients in the moderate high-altitude subgroup (2,500–3,500 m) had the lowest incidence (5.6%) of MACEs among the subgroups. The level of creatinine kinase muscle-brain isoenzymes on the first postoperative morning was lower in the high-altitude group than in the low-altitude group (66.5 [47.9, 89.0] U/L vs. 69.5 [49.3, 96.8] U/L, P = 0.003).ConclusionsHigh-altitude adaptation exhibits clinically significant cardioprotection in cardiac surgical patients.
Left atrial remodeling and voltage-guided ablation outcome in obese patients with persistent atrial fibrillation
Authors: Marzak Halim , Fitouchi Simon , Labani Aïssam , Hammann Justine , Ringele Romain , Kanso Mohamad , Cardi Thomas , Schatz Alexandre , Ohlmann Patrick , Morel Olivier , Jesel Laurence 
Published: April 2024

BackgroundObesity is a risk factor for atrial fibrillation (AF). Data regarding left atrial (LA) remodeling in obese patients are scarce. Whether obesity favors AF recurrence after catheter ablation (CA) is still controversial. We assessed the distribution of epicardial atrial fat on computed tomography (CT), LA bipolar voltage, low-voltage zone (LVZ) extent, and the outcome of voltage-guided ablation of persistent AF in obese and non-obese patients.MethodsA total of 139 patients with persistent AF undergoing a first voltage-guided ablation were enrolled and divided into two groups: 74 were non-obese and 65 were obese. Epicardial adipose tissue (EAT) was assessed on a CT scanner. LA endocardial voltage maps were obtained using a 3D mapping system in sinus rhythm. LVZ was defined as a bipolar peak-to-peak voltage amplitude &lt;0.5 mV.ResultsLA volume, voltage, and EAT amount were similar in the two groups. LVZ was less frequent in obese patients [12 (18.8%) vs. 26 (35.1%), p = 0.05], particularly on the anterior wall. The posterior and lateral EATs were correlated with posterior and lateral LVZ extent, respectively, in obese patients. After 36 months of follow-up, the AF-free survival rate was similar. Lateral EAT [odds ratio (OR) 1.21, 95% confidence interval (CI) 1–1.4, p = 0.04] and P-wave duration (OR 1.03, 95% CI 1–1.05, p = 0.03), but not body mass index (BMI), were predictors of AF recurrence after CA.ConclusionIn obese patients, LVZ was less marked than in non-obese patients with similar LA volumes, voltage, and EAT amounts. In obese patients, posterior and lateral EATs were correlated with posterior and lateral LVZ extents. Obese patients had a similar and favorable 36-month outcome after AF ablation. BMI was not predictive of AF recurrence.
MicroRNA analysis of medium/large placenta extracellular vesicles in normal and preeclampsia pregnancies
Authors: Awoyemi Toluwalase , Jiang Shuhan , Rahbar Maryam , Logentherian Prasanna , Collett Gavin , Zhang Wei , Cribbs Adam , Cerdeira Sofia , Vatish Manu 
Published: April 2024

BackgroundPreeclampsia (PE) is a hypertensive disorder of pregnancy, affecting 2%–8% of pregnancies worldwide, and is the leading cause of adverse maternal and fetal outcomes. The disease is characterized by oxidative and cellular stress and widespread endothelial dysfunction. While the precise mechanisms are not entirely understood, the pathogenesis of PE is closely linked to placental dysfunction and, to some extent, syncytiotrophoblast extracellular vesicle release (STB-EVs). These vesicles can be divided into the less well-studied medium/large EVs (220–1,000 nm) released in response to stress and small EVs (&lt;220 nm) released as a component of intercellular communication. The previously described production of m/lSTB-EVs in response to cellular stress combined with the overwhelming occurrence of cellular and oxidative stress in PE prompted us to evaluate the microRNAome of PE m/lSTB-EVs. We hypothesized that the microRNAome profile of m/lSTB-EVs is different in PE compared to normal pregnancy (NP), which might permit the identification of potential circulating biomarkers not previously described in PE.Methods/study designWe performed small RNA sequencing on medium/large STB-EVs isolated from PE and NP placentae using dual-lobe ex vivo perfusion. The sequencing data was bioinformatically analyzed to identify differentially regulated microRNAs. Identified microRNAs were validated with quantitative PCR analysis. We completed our analysis by performing an in-silico prediction of STB-EV mechanistic pathways.ResultsWe identified significant differences between PE and NP in the STB-EVs micro ribonucleic acid (microRNA) profiles. We verified the differential expression of hsa-miR-193b-5p, hsa-miR-324-5p, hsa-miR-652-3p, hsa-miR-3196, hsa-miR-9-5p, hsa-miR-421, and hsa-miR-210-3p in the medium/large STB-EVs. We also confirmed the differential abundance of hsa-miR-9-5p in maternal serum extracellular vesicles (S EVs). In addition, we integrated the results of these microRNAs into the previously published messenger RNA (mRNA) data to better understand the relationship between these biomolecules.ConclusionsWe identified a differentially regulated micro-RNA, hsa-miR-9-5p, that may have biomarker potential and uncovered mechanistic pathways that may be important in the pathophysiology of PE.
Low rates of myocardial fibrosis and ventricular arrhythmias in recreational athletes after SARS-CoV-2 infection
Authors: Miljoen Hielko , Favere Kasper , Van De Heyning Caroline , Corteville Ben , Dausin Christophe , Herbots Lieven , Teulingkx Tom , Bekhuis Youri , Lyssens Malou , Bogaert Jan , Heidbuchel Hein , Claessen Guido 
Published: April 2024

IntroductionHigh rates of cardiac involvement were reported in the beginning of the coronavirus disease 2019 (COVID-19) pandemic. This led to anxiety in the athletic population. The current study was set up to assess the prevalence of myocardial fibrosis and ventricular arrhythmias in recreational athletes with the recent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.MethodsConsecutive adult recreational athletes (≥18 years old, ≥4 h of mixed type or endurance sports/week) underwent systematic cardiac evaluation after a prior confirmed COVID-19 infection. Evaluation included clinical history, electrocardiogram (ECG), 5-day Holter monitoring, and cardiac magnetic resonance (CMR) imaging with simultaneous measurement of high-sensitive cardiac Troponin I. Data from asymptomatic or mildly symptomatic athletes (Group 1) were compared with those with moderate to severe symptoms (Groups 2–3). Furthermore, a comparison with a historical control group of athletes without COVID-19 (Master@Heart) was made.ResultsIn total, 35 athletes (18 Group 1, 10 female, 36.9 ± 2.2 years, mean 143 ± 20 days following diagnosis) were evaluated. The baseline characteristics for the Group 1 and Groups 2–3 athletes were similar. None of the athletes showed overt myocarditis on CMR based on the updated Lake Louise criteria for diagnosis of myocarditis. The prevalence of non-ischemic late gadolinium enhancement [1 (6%) Group 1 vs. 2 (12%) Groups 2–3; p = 0.603] or ventricular arrhythmias [1 Group 1 athlete showed non-sustained ventricular tachycardia (vs. 0 in Groups 2–3: p = 1.000)] were not statistically different between the groups. When the male athletes were compared with the Master@Heart athletes, again no differences regarding these criteria were found.ConclusionIn our series of recreational athletes with prior confirmed COVID-19, we found no evidence of ongoing myocarditis, and no more detection of fibrosis or ventricular arrhythmias than in a comparable athletic pre-COVID cohort. This points to a much lower cardiac involvement of COVID-19 in athletes than originally suggested.
Diversity, spatial distribution and evolution of inactive and weakly active hydrothermal deposits in the TAG hydrothermal field
Authors: Pelleter Ewan-Loiz , Principaud Mélanie , Alix Anne-Sophie , Boissier Audrey , Cheron Sandrine , Besson Florian , Altorffer Vincent , Guérin Charline , Gaillot Arnaud , Pierre Delphine , Rospabé Mathieu , Giunta Thomas , Grenet Léa , Cathalot Cecile , Cambon Marie-Anne , Fouquet Yves 
Published: April 2024

Introduction: Although, there is an increasing focus on inactive or extinct seafloor massive sulfide (SMS) deposits driven by the possibility of marine mining, only few studies have been devoted to them so far. The Trans-Atlantic Geotraverse (TAG) hydrothermal field is probably one of the best-studied hydrothermal systems even if the relict SMS deposits known since the mid-1980s have not been thoroughly explored.Objectives: The main objective of this study was to describe the characteristics of these so-called inactive sites.Methods: During four different expeditions, we acquired high-resolution acoustic data and performed numerous human occupied vehicle (HOV) dive operations including extensive rock sampling and in-situ temperature measurements.Results and Discussion: We discovered thirteen new hydrothermal mounds including six large (i.e. &gt; 5,000 m2) deposits making the TAG hydrothermal field one of the largest accumulation of hydrothermal materials (21.1 Mt) known on the seafloor. However, copper and zinc grades of the largest SMS deposits remain low (i.e. &lt; 1.4 wt%) even compared to on-land volcanogenic massive sulfide deposits. Additionally, eight areas of diffuse hydrothermal fluid flow were identified challenging the presumed inactivity of these SMS deposits and, for the first time, emphasizing the importance of low temperature (LT) hydrothermal activity in whole the TAG field. Inactive and weakly active SMS deposits exhibit a large diversity of surface mineralization (e.g. sulfides, Fe-Mn mineralization, jasper) illustrating complexity of hydrothermal activities but also different ageing history. Several mounds no longer have visible sulfide chimneys and are covered by a widespread layer of manganese and iron oxyhydroxides attesting the longevity of diffuse fluid flow at specific locations even long after last high-temperature (HT) hydrothermal activity has ceased. This contrasts with SMS deposits that are devoid of extensive LT precipitates but characterized by standing or topped sulfide chimney indicating a relatively abrupt cessation of HT hydrothermal activity.Conclusion: Together these results allow us to propose evolution models to explain the diversity of active, weakly active and inactive SMS deposits in the TAG hydrothermal field.
Turning the tides: achieving rapid and safe glucose control in adolescents with suboptimally controlled type 1 diabetes using advanced hybrid closed loop systems
Authors: Castorani Valeria , Rigamonti Andrea , Frontino Giulio , Morotti Elisa , Sandullo Federica , Scialabba Francesco , Arrigoni Francesca , Dionisi Benedetta , Foglino Riccardo , Morosini Camilla , Olivieri Gabriele , Bonfanti Riccardo 
Published: April 2024

AimMany adolescents with T1D experience a decline in metabolic control due to erratic eating habits and subpar adherence to treatment regimens. The objective of our retrospective observational study was to assess the effect of the Tandem Control IQ (CIQ) advanced hybrid closed-loop (AHCL) system on a cohort of adolescents with suboptimal glucose control.MethodsWe retrospectively evaluated 20 non-adherent patients with T1D, who were inconsistently using Multiple Daily Injections (MDIs) and flash glucose monitoring and were subsequently started and on CIQ. Glucometrics and the Glucose Risk Index were assessed at baseline and after 2 weeks, 1 month, and 6 months of CIQ use.ResultsThe study included 20 adolescents with T1D (HbA1c: 10.0% ± 1.7). Time in range (TIR) increased from 27.1% ± 13.7 at baseline to 68.6% ± 14.2 at 2 weeks, 66.6% ± 10.7 at 1 month, and 60.4% ± 13.3 at 6 months of CIQ use. Time above range (TAR) &gt;250 mg/dL decreased from 46.1% ± 23.8 to 9.9% ± 9.5 at 2 weeks, 10.8% ± 6.1 at 1 month, and 15.5% ± 10.5 at 6 months of AHCL use. Mean glucose levels improved from 251 mg/dL ± 68.9 to 175mg/dL ± 25.5 after 6 months of CIQ use. The Glucose Risk Index (GRI) also significantly reduced from 102 to 48 at 6 months of CIQ. HbA1c also improved from 10.0% ± 1.7 at baseline to 7.0% ± 0.7 after 6 months. Two patients experienced a single episode of mild diabetic ketoacidosis (DKA).ConclusionsAHCL systems provide a significant, rapid, and safe improvement in glucose control. This marks a pivotal advancement in technology that primarily benefited those who were already compliant.