bluuebunny/crossref_metadata_2025_split huggingface dataset:
Annual banned‐substance review: the Prohibited List 2008—analytical approaches in human sports drug testing
Authors: Thevis Mario , Kuuranne Tiia , Geyer Hans , Schänzer Wilhelm 
Published: January 2009

AbstractThe list of prohibited substances and methods of doping issued by the World Anti‐Doping Agency is updated and modified annually based on most recent developments and scientific data. Compounds and methods are maintained, added, or removed from the list, or they are placed in so‐called monitoring programmes that have been established to obtain reliable data on the prevalence of particular substances and methods in‐ and/or out‐of‐competition. Consequently, doping control laboratories continuously update, modify and optimize existing screening and confirmation assays to ensure utmost comprehensiveness in detecting the prohibited and monitored substances as well as chemically and pharmacologically related analogs. The annual banned‐substance review for human sports drug testing critically summarizes recent innovations in analytical approaches supporting the detection of established and newly outlawed substances and methods of doping. Literature from January 2007 through September 2008 as indexed in Medline and Web of Science was screened and articles on detection methods for substances and methods of doping in humans were compiled according to the 2008 Prohibited List of the World Anti‐Doping Agency. Few new approaches were presented for individual doping agents and the majority of reports demonstrated new options for increasing the comprehensiveness of existing doping control assays. In addition, new techniques in separation and/or ionization of analytes complementary to commonly used procedures were described, which, so far, did not meet all requirements of sports drug testing. Copyright © 2009 John Wiley & Sons, Ltd.
A Convenient Approach to Polycyclic Derivatives with a cis‐Fused 2,6‐Dioxabicyclo[4.3.0]nonane System by the Sequence Ring‐Opening/Intramolecular Ring‐Closing Enyne Metathesis/Diels–Alder Reaction
Authors: Aljarilla Ana , Murcia Maria C. , Csákÿ Aurelio G. , Plumet Joaquín 
Published: January 2009

Abstract7‐Oxanorbornene derivatives functionalized with alkyneappendages undergo intramolecular enyne metathesis reactions to give cis‐fused 2,6‐dioxabicyclo[4.3.0]nonane derivatives. These compounds have a diene functionality thatallows their reaction with dienophiles (N‐phenylmaleimide) to yield densely functionalized polycyclic compounds. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Synthesis of β‐(1→2)‐Linked Oligomannosides
Authors: Poláková Monika , Roslund Mattias U. , Ekholm Filip S. , Saloranta Tiina , Leino Reko 
Published: January 2009

Abstractβ‐(1→2)‐Linked oligomannosides constitute an important class of carbohydrate structures located on the cell surface of several Candida species, including C. albicans. As a result of the immunostimulating properties of such compounds, the upscaling of their synthesis is relevant. In this paper, a highly stereoselective synthesis of β‐(1→2)‐linked oligomannosides was performed by further development of and modifications to the methodologies described earlier in the literature. In addition to the synthesis of fully deprotected β‐(1→2)‐linked mannobiose and mannotriose, some preliminary modifications to the oligosaccharide core, resulting in close analogues with biological potential, are presented. The fully deprotected products form potential targets for screening against C. albicans and may also result in new model structures for vaccine development.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Transition‐Metal‐Catalyzed Hydroarylation Reactions of Alkynes Through Direct Functionalization of C–H Bonds: A Convenient Tool for Organic Synthesis
Authors: Kitamura Tsugio 
Published: January 2009

AbstractDirect functionalization of aromatic C–H bonds with alkynes provides an efficient synthetic protocol involving fewer reaction steps without need for prefunctionalization. This microreview presents an overview of the recently developed transition‐metal‐catalyzed hydroarylation reactions of alkynes. Special attention is paid to hydroarylation through alkyne activation processes and through arene activation processes.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Narcissism and well‐being: A longitudinal perspective
Authors: Zuckerman Miron , O'Loughlin Ryan E. 
Published: January 2009

AbstractThis study used a longitudinal design to examine both concurrent and prospective relations between narcissism and several indicators of well‐being in a non‐clinical population. Consistent with previous research, the concurrent analyses showed that (1) narcissism was related to greater well‐being with self‐esteem fully mediating the association, and (2) narcissism was related to greater self‐esteem contingency on negative interpersonal events. The prospective analyses showed that greater well‐being predicted an increase in narcissism; however, higher narcissism did not predict changes in well‐being. Lower affective reactivity to negative interpersonal events also predicted an increase in narcissism. The “would‐be” narcissist appears to be a person reporting feeling well and not overly concerned by an aversive social environment. However, narcissism does not appear to predict future benefits for one's well‐being. Copyright © 2009 John Wiley & Sons, Ltd.
PMS2 involvement in patients suspected of Lynch syndrome
Authors: Niessen Renée C. , Kleibeuker Jan H. , Westers Helga , Jager Paul O. J. , Rozeveld Dennie , Bos Krista K. , Boersma‐van Ek Wytske , Hollema Harry , Sijmons Rolf H. , Hofstra Robert M. W. 
Published: January 2009

AbstractIt is well‐established that germline mutations in the mismatch repair genes MLH1, MSH2, and MSH6 cause Lynch syndrome. However, mutations in these three genes do not account for all Lynch syndrome (suspected) families. Recently, it was shown that germline mutations in another mismatch repair gene, PMS2, play a far more important role in Lynch syndrome than initially thought. To explore this further, we determined the prevalence of pathogenic germline PMS2 mutations in a series of Lynch syndrome‐suspected patients. Ninety‐seven patients who had early‐onset microsatellite instable colorectal or endometrial cancer, or multiple Lynch syndrome‐associated tumors and/or were from an Amsterdam Criteria II‐positive family were selected for this study. These patients carried no pathogenic germline mutation in MLH1, MSH2, or MSH6. When available, tumors were investigated for immunohistochemical staining (IHC) for PMS2. PMS2 was screened in all patients by exon‐by‐exon sequencing. We identified four patients with a pathogenic PMS2 mutation (4%) among the 97 patients we selected. IHC of PMS2 was informative in one of the mutation carriers, and in this case, the tumor showed loss of PMS2 expression. In conclusion, our study confirms the finding of previous studies that PMS2 is more frequently involved in Lynch syndrome than originally expected. © 2009 Wiley‐Liss, Inc.
Synovial sarcoma of the Eustachian tube
Authors: Lin Hsin‐Ching , Friedman Michael , Kuo Fang‐Ying , Huang Hsuan‐Ying 
Published: January 2009

AbstractBackgroundSynovial sarcoma is a rare, aggressive high‐grade neoplasm with poor prognosis. Synovial sarcoma is usually encountered in the lower extremities of young adults; only a few cases have been reported in the head and neck region.MethodsWe describe a case of a 44‐year‐old man seen with a 3‐month history of progressive nasal obstruction. Nasoendoscopy revealed a pink polypoid mass filling in the entire right posterior nasal cavity. CT and MRI studies showed that a hyperintense mass on the right nasopharynx extending to the nasal cavity anteriorly and the oropharynx inferiorly. During the operation, the mass was noted as originating from the lower portion of anterior cushion of the right Eustachian tube. We endoscopically removed the tumor and part of the anterior cushion of the right Eustachian tube. Because of the large tumor size (7.0 × 3.5 cm), we took the tumor out transorally.ResultsThe histopathology and genetic analysis confirmed the diagnosis of monophasic synovial sarcoma prominent myxoid pattern. The patient then underwent adjuvant irradiation to 64.8 Gy, and he was free of recurrence and distant metastasis in the 5‐year follow‐up.ConclusionTo our knowledge, this is the first case report of synovial sarcoma of the Eustachian tube. Synovial sarcoma should be included in the differential diagnosis when managing the Eustachian tube region mass. Recommended treatment is surgery and postoperative adjuvant radiotherapy. © 2009 Wiley Periodicals, Inc. Head Neck, 2009
Effectiveness of salvage selective and modified radical neck dissection for regional pathologic lymphadenopathy after chemoradiation
Authors: van der Putten Lisa , van den Broek Guido B. , de Bree Remco , van den Brekel Michiel W. M. , Balm Alfons J. M. , Hoebers Frank J. P. , Doornaert Patricia , Leemans C. René , Rasch Coen R. N. 
Published: January 2009

AbstractBackgroundThe objective of this study was to evaluate the effectiveness and safety of our careful observational strategy and neck dissections and the accuracy of ultrasound‐guided fine‐needle aspiration cytology, and to determine the prognostic factors for outcome and regional control after primary chemoradiation. Diagnostic evaluation of the regional status after concurrent chemoradiation for advanced head and neck cancer remains difficult, and the indications for a salvage neck dissection and its extent are not clearly defined.MethodsIn a series of 540 patients, there was suspicion of regional residual or recurrent disease after chemoradiation in 61 patients who underwent 68 salvage neck dissections and 68 patients who were considered unresectable. For the patients with salvage neck dissection, the accuracy of ultrasound‐guided fine‐needle aspiration cytology was determined. Disease control in the neck, disease‐specific and overall survival, and parameters that may have prognostic value for the outcome were evaluated.ResultsNeck dissection specimens contained viable tumor in 26 (43%) patients. Of these, 13 had selective neck dissections and 13 modified radical neck dissections. Ultrasound‐guided fine‐needle aspiration cytology had a sensitivity of 80% and specificity of 42%. Nine patients developed a regional recurrence after salvage neck dissection (5 located in contralateral neck). Five‐year regional control and overall survival rates were 79% and 36%, respectively. Significant prognostic factors for overall survival were surgical margins and “residual versus recurrent disease” in multivariate analysis.ConclusionConsidering the good regional control rate and the high rate of unnecessary neck dissections with a theoretical planned neck dissection strategy, we conclude that a careful observational strategy is worthwhile and safe. For the evaluation of radiation treatment response, ultrasound‐guided fine‐needle aspiration cytology has a low specificity. © 2009 Wiley Periodicals, Inc. Head Neck, 2009
Endoscopic laser surgery of early glottic cancer: Involvement of the anterior commissure
Authors: Rödel Ralph M. W. , Steiner Wolfgang , Müller Roland M. , Kron Martina , Matthias Christoph 
Published: January 2009

AbstractBackgroundEarly glottic cancer can be cured with transoral laser resection, but in cases with anterior commissure involvement, there is still controversy concerning the best treatment modality.MethodsThe impact of anterior commissure involvement on local control was analyzed in a retrospective review of 444 patients with early glottic cancer (pT1a–pT2a) treated between 1986 and 2004 with transoral laser microsurgical resection.ResultsThe anterior commissure was involved in 153 cases; the 5‐year local control rate with and without anterior commissure involvement was 73% versus 89% for T1a and 68% versus 86% for T1b tumors. For T2a lesions, the 5‐year local control rate was 76%, irrespective of anterior commissure involvement.ConclusionIn early glottic cancer treated by transoral laser microsurgery, a decrease in local control is evident in case of anterior commissure involvement for T1a and T1b but not for T2a tumors. © 2009 Wiley Periodicals, Inc. Head Neck, 2009
Alternative reconstructive choices for anterolateral thigh flap dissection in cases in which no sizable skin perforator is available
Authors: Hsieh Ching‐Hua , Yang Johnson Chia‐Shen , Chen Chien‐Chang , Kuo Yur‐Ren , Jeng Seng‐Feng 
Published: January 2009

AbstractBackgroundAlternative choices were proposed to facilitate a successful reconstruction when no sizable skin perforator is encountered in anterolateral thigh (ALT) flap dissection.MethodsAlternative choices such as harvest of a tensor fascia latae (TFL) flap, elevation of an anteromedial thigh (AMT) flap, use of a free muscle component with full‐thickness skin graft coverage, and use of another donor flap were performed.ResultsBetween August 1995 and December 2006, 10 of 923 patients underwent ALT flap elevation with no sizable perforators. Of them, each of the 4 patients received reconstruction with a free TFL flap, 3 with an AMT flap, 2 with a free muscle flap, and 1 with a radial forearm flap. There was 1 TFL flap failure due to postoperative venous thrombosis, and the defect was repaired by an AMT flap.ConclusionWhen no sizable perforator is encountered, successful reconstruction could still be achieved by the proposed alternative choices. © 2009 Wiley Periodicals, Inc. Head Neck, 2009
Positive personal changes in the aftermath of head and neck cancer diagnosis: A qualitative study in patients and their spouses
Authors: Ruf Michelle , Büchi Stefan , Moergeli Hanspeter , Zwahlen Roger A. , Jenewein Josef 
Published: January 2009

AbstractBackgroundThere is increasing evidence that serious and life‐threatening illnesses such as malignant tumors not only can lead to increased psychological stress, but also can lead to positive changes.MethodsIn this qualitative study, 31 patients with head and neck cancer and 25 women partners were interviewed with regard to positive personal changes (posttraumatic growth). The audiotaped responses were analyzed using qualitative context analysis.ResultsA total of 25 patients (81%) and their women partners (84%) reported positive changes. Qualitative content analysis revealed 3 different categories of growth: attitudes toward life, personal strength, and relationships. Partners reported significantly more positive changes in relationships, especially, within the partnership. The total amount of positive change was almost equal.ConclusionPositive personal changes are frequently reported by patients and by significant others. The total amount of positive change is almost equal in patients and their women partners, but wives experience more positive changes within the partnership. © 2009 Wiley Periodicals, Inc. Head Neck 2009
A non‐randomized study to investigate the effects of the atypical antipsychotic aripiprazole on the steady‐state pharmacokinetics of lamotrigine in patients with bipolar I disorder
Authors: Schieber Frank C , Boulton David W , Balch Alfred H , Croop Robert , Mallikaarjun Suresh , Benson Jeannine , Carlson Berit X 
Published: January 2009

AbstractObjectiveTo determine the effect of aripiprazole on steady‐state pharmacokinetics of lamotrigine in patients with bipolar I disorder who were clinically stable on lamotrigine (100–400 mg/day) for ≥4 weeks.MethodsIn this open‐label study, aripiprazole was administered at 10 mg/day for 3 days, 20 mg/day for 3 days, then 30 mg/day for 8 days. Blood samples were collected on Days –1 and 14 for determination of lamotrigine steady‐state pharmacokinetic parameters. Safety and tolerability were assessed.ResultsEighteen patients were administered aripiprazole in combination with lamotrigine. Geometric mean (GM) values for lamotrigine maximum plasma concentration were similar for lamotrigine alone (26 ng/mL) and with co‐administered aripiprazole (23 ng/mL). GM values for plasma lamotrigine area under the concentration–time curve (AUCτ) were comparable for lamotrigine alone (434 ng/h/mL) and with co‐administered aripiprazole (394 ng/h/mL). MedianTmaxof lamotrigine alone and combined with aripiprazole was 1.98 and 0.77 h, respectively. No changes to lamotrigine dose‐normalized plasma trough concentrations were observed with co‐administered aripiprazole. Sixteen patients (88.9%) experienced ≥1 adverse event (AE), the most common of which was insomnia (n = 6).ConclusionsAripiprazole had no meaningful effect on lamotrigine steady‐state pharmacokinetics in patients with bipolar I disorder. No dosage adjustment of lamotrigine is required and the combination was generally safe and well tolerated. Copyright © 2009 John Wiley & Sons, Ltd.
Clinical psychology training in sleep and sleep disorders
Authors: Meltzer Lisa J. , Phillips Cindy , Mindell Jodi A. 
Published: January 2009

AbstractThere is growing evidence to suggest that clinical psychologists would benefit from more training in sleep and sleep disorders. Sleep disturbances are commonly comorbid with mental health disorders and this relationship is often bidirectional. In addition, psychologists have become integral members of multidisciplinary sleep medicine teams and there are not enough qualified psychologists to meet the clinical demand. The purpose of this study was to evaluate the current education on sleep and sleep disorders provided to clinical psychology predoctoral students and interns. Directors of graduate programs and internships (N=212) completed a brief online survey on sleep education in their program. Only 6% of programs offers formal didactic courses in sleep, with 31% of programs offering training in the treatment of sleep disorders. There are few programs with sleep faculty (16%), and most reported that their institutions were ineffective in providing sleep education. Thirty‐nine percent of training directors reported they would implement a standard curriculum on sleep, if available. The findings from this study suggest that more opportunities are needed for trainees in clinical psychology to gain didactic and clinical experience with sleep and sleep disorders. © 2009 Wiley Periodicals, Inc. J Clin Psychol: In Session 65:1–14, 2009.
Next steps for clinicians in religious and spiritual therapy: an endpiece
Authors: Aten Jamie D. , Worthington Everett L. 
Published: January 2009

AbstractTo conclude this issue of the Journal of Clinical Psychology: In Session, the authors identify several next steps for clinicians interested in religious and spiritual therapy. They call for more clinically useful definitions of religion and spirituality and suggest that new methods of clinical practice that employ both Western and Eastern religion and spirituality need to be developed and tested. The need for more clinically focused religious and spiritual assessments is highlighted. They recommend greater clergy–psychotherapist collaboration and propose that clinicians lead and collaborate with researchers to further meaningful research on religion and spirituality. Finally, the authors identify areas of graduate training that require strengthening and provide corresponding guidelines. © 2009 Wiley Periodicals, Inc. J Clin Psychol: In Session 65:1–6, 2009.
Crown formation during tooth development and tissue engineering
Authors: Nait Lechguer Adnane , Kuchler‐Bopp Sabine , Lesot Herve 
Published: January 2009

AbstractConsidering tooth crown engineering, three main parameters have to be taken into account: (1) the relationship between crown morphology and tooth functionality, (2) the growth of the organ, which is hardly compatible with the use of preformed scaffolds, and (3) the need for easily available nondental competent cell sources. In vitro reassociation experiments using either dental tissues or bone marrow‐derived cells (BMDC) have been designed to get information about the mechanisms to be preserved in order to allow crown engineering. As the primary enamel knot (PEK) is involved in signaling crown morphogenesis, the formation and fate of this structure was investigated (1) in heterotopic reassociations between embryonic day 14 (ED14) incisor and molar enamel organs and mesenchymes, and (2) in reassociations between ED14 molar enamel organs and BMDC. A PEK formed in cultured heterotopic dental tissue reassociations. The mesenchyme controls the fate of the EK cells, incisor or molar‐specific using apoptosis as criterion, and functionality to drive single/multiple cusps tooth development. Although previous investigations showed that they might differentiate as odontoblast‐ or ameloblast‐like cells, BMDC reassociated to an enamel organ could not support the development of multicusp teeth. These cells apparently could neither maintain nor stimulate the formation of a PEK. J. Exp. Zool. (Mol. Dev. Evol.) 312B:399–407, 2009. © 2009 Wiley‐Liss, Inc.
Synthesis of [3H]ABT‐518, a matrix metalloproteinase inhibitor (MMPI) labeled in the phenyl rings
Authors: Raja Shirish N. , Surber Bruce W. , Du Jia , Cross Jeffrey L. 
Published: January 2009

AbstractA novel matrix metalloproteinase inhibitor, ABT‐518, [S‐(R*, R*)]‐N‐[1‐(2, 2‐dimethyl‐1,3‐dioxol‐4‐yl)‐2‐[[4‐[4‐(trifluoromethoxy)‐phenoxy]phenyl]sulfonyl]ethyl]‐N‐hydroxyformamide, was labeled with tritium in two phenyl rings in a seven‐step synthesis. The overall radiochemical yield of [3H]ABT‐518 in seven steps starting from 1‐(methylsulfonyl)‐4‐[4‐(trifluoromethoxy)phenoxy]benzene was 6.2% with the radiochemical purity of 99.4%. Copyright © 2009 John Wiley & Sons, Ltd.
Gene cloning and utility phophorylation assay of a protein‐fused substrate for a highly sensitive detection of cdc2 protein kinase using a radioisotope detection technique for the development of a protein biochip
Authors: Ko Kyong‐Cheol , Choi Mi Hee , Park Sang Hyun 
Published: January 2009

AbstractThe prototype of the cdc2 protein kinase in mammalian cells regulates its entry into mitosis by phosphorylating a group of key proteins in the major cell cycle transitions. In this study, using the mep45 gene encoding the 45 kDa major envelope protein (Mep45) of Selenomonas ruminantium, a rumen bacteria, a Mep45‐fused substrate (PKTPKKAKKL‐Mep45, MFS‐cdc2) was cloned to detect the activity of cdc2 protein kinase. We report here on a strategy for the detection of a phosphorylation of a substrate catalyzed by cdc2 protein kinase by using a radioisotope detection technique. It is possible to constantly obtain a reasonable quantity of MFS‐cdc2 for the cdc2 protein kinase assay and its cost can be as low as a synthesized peptide. Results of the study indicate that the Mep45‐fused protein can be used effectively as a substrate for detecting the activity of cdc2 protein kinase and it can be used in developing a protein biochip for a high‐throughput screening and also for studying protein–protein interactions. Copyright © 2009 John Wiley & Sons, Ltd.