bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating health utility score through direct and indirect methods in patients with chronic rhinosinusitis
Authors: Chitsuthipakorn Wirach , Pracharktam Narissara , Phetpong Juthaporn , Kowatanamongkon Patlada , Mongkolkul Kittichai , Snidvongs Kornkiat 
Published: March 2024

AbstractIntroductionEuroQol‐5‐dimensions‐5‐levels (EQ‐5D‐5L), visual analog scale (VAS), time trade‐off (TTO), and standard gamble (SG) are used for the assessment of Health Utility Scores (HUS) of chronic rhinosinusitis (CRS). This study aimed to determine the overall HUS of CRS, the factors which influence the HUS, and the preferable method.MethodsA cross‐sectional study was conducted. Patients with primary CRS were recruited. Clinical and socioeconomic data together with HUS were assessed. Four HUS scores determined from the four different methods were compared.ResultsA total of 335 patients were enrolled. The overall HUS, as measured by EQ‐5D‐5L, VAS, TTO, and SG, was 0.88 ± 0.14, 0.79 ± 0.17, 0.89 ± 0.15, and 0.86 ± 0.16, respectively. The multivariable linear regression revealed that each increasing 22‐item sinonasal outcome test (SNOT‐22) score predicted a reduction of 0.002 to 0.003 in HUS (all methods, p < 0.01). Patients who scheduled for endoscopic sinus surgery had 0.06 to 0.11 HUS lower than other groups in EQ‐5D‐5L and VAS (all p < 0.05). Higher endoscopy score, age, presence of comorbid airway diseases, and lower education correlated with lower HUS (p < 0.05). Given the HUS results and regression models, the EQ‐5D‐5L is likely the preferable choice.ConclusionThe overall HUS of CRS was approximately 0.79–0.89. High SNOT‐22 score and those who failed medications, presence of comorbid AR/asthma, increased age, high endoscopy score, and low education negatively impacted HUS. Our data suggest that EQ‐5D‐5L is a preferable method for measuring HUS in patients with CRS.
Plants as a cost‐effective source for customizable photosynthetic wound dressings: A proof of concept study
Authors: González‐Itier Sergio , Miranda Miguel , Corrales‐Orovio Rocío , Vera Constanza , Veloso‐Giménez Valentina , Cárdenas‐Calderón Camila , Egaña José Tomás 
Published: March 2024

AbstractOxygen is essential for tissue regeneration, playing a crucial role in several processes, including cell metabolism and immune response. Therefore, the delivery of oxygen to wounds is an active field of research, and recent studies have highlighted the potential use of photosynthetic biomaterials as alternative oxygenation approach. However, while plants have traditionally been used to enhance tissue regeneration, their potential to produce and deliver local oxygen to wounds has not yet been explored. Hence, in this work we studied the oxygen‐releasing capacity of Marchantia polymorpha explants, showing their capacity to release oxygen under different illumination settings and temperatures. Moreover, co‐culture experiments revealed that the presence of these explants had no adverse effects on the viability and morphology of fibroblasts in vitro, nor on the viability of zebrafish larvae in vivo. Furthermore, oxygraphy assays demonstrate that these explants could fulfill the oxygen metabolic requirements of zebrafish larvae and freshly isolated skin biopsies ex vivo. Finally, the biocompatibility of explants was confirmed through a human skin irritation test conducted in healthy volunteers following the ISO‐10993‐10‐2010. This proof‐of‐concept study provides valuable scientific insights, proposing the potential use of freshly isolated plants as biocompatible low‐cost oxygen delivery systems for wound healing and tissue regeneration.
Immunomodulation in allergic rhinitis: Insights from Th2 cells and NLRP3/IL‐18 pathway
Authors: Hu Xiaoyan , Liu Shuang , Jing Zhang , He Yuxiao , Qin Gang , Jiang Liang 
Published: March 2024

AbstractAllergic rhinitis (AR) is characterized by nasal symptoms such as rubbing and sneezing, often triggered by allergen exposure. The purpose of this study is to dissect the roles of NLRP3‐mediated immune modulation and macrophage pyroptosis in modulating T cell differentiation within the context of ovalbumin (OVA)‐induced AR in mice. OVA‐induced AR was established in mice, evaluating nasal symptoms, macrophage infiltration, cytokine levels, and T cell differentiation. Manipulations using NLRP3−/−, ASC−/− mice, clodronate liposome treatment, and NLRP3 inhibitor MCC950 were performed to assess their impact on AR symptoms and immune responses. Following OVA stimulation, increased nasal symptoms were observed in the OVA group along with augmented GATA3 expression and elevated IL‐4 and IL‐1b levels, indicative of Th2 polarization and cellular pyroptosis involvement. NLRP3−/− and ASC−/− mice exhibited reduced CD3+ T cells post OVA induction, implicating cellular pyroptosis in AR. Macrophage depletion led to decreased IgE levels, highlighting their involvement in allergic responses. Further investigations revealed enhanced macrophage pyroptosis, influencing Th1/Th2 differentiation in AR models. IL‐18 released through NLRP3‐mediated pyroptosis induced Th2 differentiation, distinct from IL‐1b. Additionally, MCC950 effectively mitigated AR symptoms by modulating Th2 responses and reducing macrophage infiltration. This comprehensive study unravels the pivotal role of NLRP3‐mediated immune modulation and macrophage pyroptosis in Th1/Th2 balance regulation in OVA‐induced AR. Targeting NLRP3 pathways with MCC950 emerged as a promising strategy to alleviate AR symptoms, providing insights for potential therapeutic interventions in AR management.
Experimental investigation on the rock breaking mechanism of electrode bit by high‐voltage electric pulses
Authors: Liu Weiji , Zhang Youjian , Zhu Xiaohua , Hu Hai 
Published: March 2024

AbstractBecause of the low rate of penetration (ROP) and high cost of traditional rotary rock breaking, it is important to explore some unconventional new rock breaking methods. High‐voltage electrical pulse (HVEP) drilling has attracted much attention because of its advantages such as environmental protection, good borehole wall quality, and high rock breaking efficiency. This paper independently designs and builds a complete indoor experimental platform of HVEP electric breakdown, and selects the self‐designed classic coaxial type and cross‐type electrode bits to carry out laboratory experiments of HVEP rock‐breaking, to truly reveal the rock breaking mechanism of HVEP drilling and further promote its industrial application. The influence of the anode structure of electrode bit, liquid insulation medium, drilling fluid circulation condition, and pulse voltage on rock breaking mechanism are investigated. The findings indicate that the bottom‐hole morphology of the rock sample is related to the electrode bit structure. The S‐type electrode bit has a certain discharge blind area, which is not conducive to the rock breaking of HVEP. With the increase of pre‐charging voltage, the effective discharge rate (EDR) of both electrode bits increases gradually, trending towards 100% as the pre‐charging voltage grows. Under non‐circulating working conditions, greater conductivity of liquid medium results in a lower EDR of electrode bits. In all kinds of liquid media, under low voltage (pre‐charging voltage <15 kV), the single pulse penetration depth (SPPD) under the non‐circulating working condition is larger than that of the circulating condition, in contrast, at a higher voltage (pre‐charging voltage >15 kV), the SPPD under the circulating condition is larger than that the non‐circulating condition. To further observe the generation of plasma channel and the rock damage characterization of HVEP, this paper also establishes a three‐dimensional numerical model of dynamic electrical breakdown of red sandstone to reproduce the generation of plasma channel, which can be mutually confirmed by indoor experimental results. The research results are essential for a deeper understanding of the rock breaking mechanism by electric pulse and for providing some theoretical guidance for the industrial application of electric pulse drilling technology.
Testing for galactic cosmic ray warming hypothesis using the notion of block‐exogeneity
Authors: Triacca Umberto 
Published: March 2024

AbstractIn this article, we consider the notion of block‐exogeneity and establish a characterization of it. We use this characterization to propose a procedure to test for block‐exogeneity in a trivariate system. The proposed procedure has been applied to test the so‐called galactic cosmic ray warming hypothesis. The galactic cosmic ray warming hypothesis suggests the existence of an indirect solar influence on Earth's climate. Our results seem to imply that this hypothesis does not hold. In particular, we find that the global temperature is block‐exogenous with respect to both sunspot numbers (a measure of the solar activity) and galactic cosmic rays. This implies that the supposed indirect causal link from solar activity to temperature (through cosmic rays), postulated by the galactic cosmic ray warming hypothesis, does not appear to exist.
Compound probiotics microcapsules improve milk yield and milk quality of dairy cows by regulating intestinal flora
Authors: Wu Rina , Chang Shihan , Zhang Henan , Yang Xujing , Gu Ruixia , Wang Shuo , Liu Xiaoyu , Liu Xiaoyan , Bat‐Ochir Munkhdelger , Wu Junrui 
Published: March 2024

AbstractTo address the issues of probiotic activity loss during storage and feeding, as well as the limited efficacy of single probiotics, a solution was devised by embedding a mixture of Bacillus coagulans SN‐8 (SN‐8) and Saccharomyces boulardii SN‐6 (SN‐6) in a gel. The initial step involved screening the probiotic microcapsules' preparation method and wall material. Using sodium alginate and β‐cyclodextrin as composite wall material and chitosan as the outer coating material allowed for an embedding rate of 82.11% in composite probiotic microcapsules prepared by the air atomization method. Next, in vitro, simulated digestion experiments were conducted to determine the number of viable bacteria and the release rate of the microcapsules. The results showed that compared to the free strain, the mixed probiotic microcapsules retained a survival rate of 67.5% after 3 h of simulated gastric juice exposure and 70.56% after 42 days of storage at 4°C. This demonstrated higher survival rates and storage stability. The prepared probiotic microcapsules were then administered to dairy cows. 16S rDNA gene sequencing showed that consumption of the microcapsules reduced the number of harmful bacteria, such as Paeniclostridium, in the intestinal tract of dairy cows while accelerating the growth of beneficial bacteria, such as Bifidobacterium. In particular, this resulted in a significant improvement in the lactation performance of the cows, with a 4.5% increase in milk fat content, a 92.5% increase in milk protein content, and a 3.5% increase in milk urea nitrogen content (6.75 mL/dL). In conclusion, probiotic microcapsules can effectively regulate intestinal flora, improving milk production, and quality in dairy cows.
Doubly sequenceable groups
Authors: Javaheri Mohammad 
Published: March 2024

AbstractGiven a sequence in a finite group with , let be the sequence of consecutive quotients of defined by and for . We say that is doubly sequenceable if there exists a sequence in such that every element of appears exactly twice in each of and . We show that if a group is abelian, odd, sequenceable, R‐sequenceable, or terraceable, then it is doubly sequenceable. We also show that if is an odd or sequenceable group and is an abelian group, then is doubly sequenceable.
Pediatric palliative care for metabolic diseases: 20‐year epidemiological survey of outpatients at a Brazilian quaternary hospital
Authors: Spolador Gustavo Marquezani , Bueno Clarissa , Polastrini Rita Tiziana Verardo , Zoboli Ivete , Henrique Ana Cristina , Freitas Elaine , do Nascimento Andréa Gislene , Pugliese Camila , Kok Fernando , Barbosa Silvia Maria de Macedo 
Published: March 2024

AbstractThe interface between pediatric palliative care (PPC) and inborn metabolic diseases (IMD) remains incipient, though these conditions fill the state of art of complex chronic diseases, eligible to this health approach. We analyzed the medical records of PPC clinic during the years 2001 to 2021 and the IMD outpatients. We established a parallel with the world scientific literature concerning the epidemiology of PPC and IMD. Among outpatients, 14% were diagnosed with IMD, which were referred to the PPC service earlier compared to Non‐IMD cases. The Group 3 (complex molecules) was the most frequent (64.7%), following by Group 1 representing by small molecules (21.6%), the latter having a lower median age at diagnosis when compared to the former (0.7 vs. 5.2 years, p = 0.001). The sphingolipidoses were the pathologies most frequent in our cohort, in line with what was observed in the literature. There were no differences between IMD groups in terms of diagnosis and PPC referral age, however in Non‐IMD conditions, the age of diagnosis were earlier than IMD. Nevertheless, IMD group showed lower age of referral to PPC. The IMD comprises large fraction of outpatients in the PPC setting, thus further studies are needed in this field.
Predictable Synthesis of 3D Polymer Networks Using Crystal Component‐Linking
Authors: Anan Shizuka , Kokado Kenta , Sada Kazuki 
Published: March 2024

AbstractControlled synthesis of 3D polymer networks presents a significant challenge because of the complexity of the polymerization reaction in solution. In this study, a polymerization system that facilitates the prediction of a polymer network structure via percolation simulations is realized. The most significant difference between general percolation simulations and experimental polymerization systems is the mobility of the molecules during the reaction. A crystal component‐linking method that connects the precisely arranged monomer as a supramolecular crystalline state to imitate the simple percolation theory is adopted. The percolation simulation based on the crystal structure of the arranged monomers is used to accurately calculate the gelation point, gel fraction, degree of swelling, and atomic formula, which correspond with the experimental results. This suggests that the network structures polymerized via the crystal component‐linking method can be predicted precisely by a simple percolation simulation. Further, the percolation simulation predicts the structures of the loop, branched polymer, and crosslinking point, which are difficult to measure experimentally. The polymerization of precisely‐arranged immobilized monomers in supramolecular structures is promising in synthesizing precisely controlled polymer networks.
Nutrition, endocannabinoids, and the use of cannabis: An overview for the nutrition clinician
Authors: Russell Lindsey , Condo Kayla , DeFlorville Tiffany 
Published: March 2024

AbstractThe endocannabinoid system (ECs) is composed of multiple signaling compounds and receptors within the central and peripheral nervous system along with various organs, including the gut, liver, and skeletal muscle. The ECs has been implicated in metabolism, gut motility, and eating behaviors. The ECs is altered in disease states such as obesity. Recent studies have clarified the role of the gut microbiome and nutrition on the ECs. Exogenous cannabinoid (CB) use, either organic or synthetic, stimulates the ECs through CB1 and CB2 receptors. However, the role of CBs is unclear in regard to nutrition optimization or to treat disease states. This review briefly summarizes the effect of the ECs and exogenous CBs on metabolism and nutrition. With the increased legalization of cannabis, there is a corresponding increased use in the United States. Therefore, nutrition clinicians need to be aware of both the benefits and harm of cannabis use on overall nutrition status, as well as the gaps in knowledge for future research and guideline development.
When rationality meets intuition: A research agenda for software design decision‐making
Authors: Pretorius Carianne , Razavian Maryam , Eling Katrin , Langerak Fred 
Published: March 2024

AbstractAs society's reliance on software systems escalates over time, so too does the cost of failure of these systems. Meanwhile, the complexity of software systems, as well as of their designs, is also ever‐increasing, influenced by the proliferation of new tools and technologies to address intended societal needs. The traditional response to this complexity in software engineering and software architecture has been to apply rationalistic approaches to software design through methods and tools for capturing design rationale and evaluating various design options against a set of criteria. However, research from other fields demonstrates that intuition may also hold benefits for making complex design decisions. All humans, including software designers, use intuition and rationality in varying combinations. The aim of this article is to provide a comprehensive overview of what is known and unknown from existing research regarding the use and performance consequences of using intuition and rationality in software design decision‐making. To this end, a systematic literature review has been conducted, with an initial sample of 3909 unique publications and a final sample of 26 primary studies. We present an overview of existing research, based on the literature concerning intuition and rationality use in software design decision‐making and propose a research agenda with 14 questions that should encourage researchers to fill identified research gaps. This research agenda emphasizes what should be investigated to be able to develop support for the application of the two cognitive processes in software design decision‐making.
Development of membrane protein‐based vaccine against lumpy skin disease virus (LSDV) using immunoinformatic tools
Authors: Salauddin Md. , Kayesh Mohammad Enamul Hoque , Ahammed Md. Suruj , Saha Sukumar , Hossain Md. Golzar 
Published: March 2024

AbstractIntroductionLumpy skin disease, an economically significant bovine illness, is now found in previously unheard‐of geographic regions. Vaccination is one of the most important ways to stop its further spread.AimTherefore, in this study, we applied advanced immunoinformatics approaches to design and develop an effective lumpy skin disease virus (LSDV) vaccine.MethodsThe membrane glycoprotein was selected for prediction of the different B‐ and T‐cell epitopes by using the immune epitope database. The selected B‐ and T‐cell epitopes were combined with the appropriate linkers and adjuvant resulted in a vaccine chimera construct. Bioinformatics tools were used to predict, refine and validate the 2D, 3D structures and for molecular docking with toll‐like receptor 4 using different servers. The constructed vaccine candidate was further processed on the basis of antigenicity, allergenicity, solubility, different physiochemical properties and molecular docking scores.ResultsThe in silico immune simulation induced significant response for immune cells. In silico cloning and codon optimization were performed to express the vaccine candidate in Escherichia coli. This study highlights a good signal for the design of a peptide‐based LSDV vaccine.ConclusionThus, the present findings may indicate that the engineered multi‐epitope vaccine is structurally stable and can induce a strong immune response, which should help in developing an effective vaccine towards controlling LSDV infection.
Regulation and function of transposable elements in cancer genomes
Authors: Lee Michael , Ahmad Syed Farhan , Xu Jian 
Published: March 2024

AbstractOver half of human genomic DNA is composed of repetitive sequences generated throughout evolution by prolific mobile genetic parasites called transposable elements (TEs). Long disregarded as “junk” or “selfish” DNA, TEs are increasingly recognized as formative elements in genome evolution, wired intimately into the structure and function of the human genome. Advances in sequencing technologies and computational methods have ushered in an era of unprecedented insight into how TE activity impacts human biology in health and disease. Here we discuss the current views on how TEs have shaped the regulatory landscape of the human genome, how TE activity is implicated in human cancers, and how recent findings motivate novel strategies to leverage TE activity for improved cancer therapy. Given the crucial role of methodological advances in TE biology, we pair our conceptual discussions with an in-depth review of the inherent technical challenges in studying repeats, specifically related to structural variation, expression analyses, and chromatin regulation. Lastly, we provide a catalog of existing and emerging assays and bioinformatic software that altogether are enabling the most sophisticated and comprehensive investigations yet into the regulation and function of interspersed repeats in cancer genomes.
Prospects of molecular hydrogen in cancer prevention and treatment
Authors: Zhou Wenchang , Zhang Jie , Chen Wankun , Miao Changhong 
Published: March 2024

AbstractGas signaling molecules, including carbon monoxide (CO), nitric oxide (NO), and hydrogen sulfide (H2S), have been shown to have cancer therapeutic potential, pointing to a new direction for cancer treatment. In recent years, a series of studies have confirmed that hydrogen (H2), a weakly reductive gas, also has therapeutic effects on various cancers and can mitigate oxidative stress caused by radiation and chemotherapy, reducing tissue damage and immunosuppression to improve prognosis. Meanwhile, H2also has immunomodulatory effects, inhibiting T cell exhaustion and enhancing T cell anti-tumor function. It is worth noting that human intestinal flora can produce large amounts of H2daily, which becomes a natural barrier to maintaining the body’s resistance to diseases such as tumors. Although the potential anti-tumor mechanisms of H2are still to be investigated, previous studies have shown that H2can selectively scavenge highly toxic reactive oxygen species (ROS) and inhibit various ROS-dependent signaling pathways in cancer cells, thus inhibiting cancer cell proliferation and metastasis. The ROS scavenging ability of H2may also be the underlying mechanism of its immunomodulatory function. In this paper, we review the significance of H2produced by intestinal flora on the immune homeostasis of the body, the role of H2in cancer therapy and the underlying mechanisms, and the specific application of H2to provide new ideas for the comprehensive treatment of cancer patients.