bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anthropogenic Coal Ash as a Contaminant in an Underwater Search. II. Beyond Beryllium, Lanthanum, and Uranium
Authors: Gallardo Patricio A. 
Published: March 2024

Abstract
It has been shown that the Beryllium, Lanthanum and Uranium concentrations in the “BeLaU” spherules are in the expected ranges of coal ash. It is reported that the average elemental concentration of 12 microspherules can be found in the COALQUAL database in 98% (49/50) of the elements examined. The “BeLaU pattern” is found to be not unique, it can be reproduced using a coal ash standard (SRM1633a) and a chondritic normalization. The ratio of rare-earth elements in the “BeLaU” spherules and the SMR1633a sample is of order unity. Comparisons against SRM1633a return only two elements with abundances statistically significantly lower than the coal ash standard of reference (or fractions of order unity), agreeing in 96% (52/54) of the elements tested. No elements show higher abundance than 10× the reference standard. Terrestrial coal ash is curiously very similar to the collected spherules. Origin from a recent meteoritic event remains uncertain.
Lunar Boulder Fields as Indicators of Recent Tectonic Activity
Authors: Nypaver Cole , Watters Thomas , Thomson Bradley , Bramson Ali , Cahill Joshua , Clark Jaclyn , Elder Catherine , Fassett Caleb , Morgan Gareth , Pérez Cortés Santa Lucía , Powell Tyler 
Published: March 2024

Abstract
Wrinkle ridges are the predominant tectonic structure on the nearside lunar maria. Although lunar wrinkle ridge formation began as early as ∼3.9–4.0 Ga, recent investigations have identified wrinkle ridges in the lunar maria that were tectonically active as recently as the Copernican period of lunar geologic history. Some of those geologically young wrinkle ridges were identified by the presence of dense fields of meter-scale boulders on their scarps and topographic crests. Other investigations have identified recently active lunar wrinkle ridges that lack the ubiquitous presence of boulder fields, thereby rendering the presence of boulder fields ambiguous in the search for ongoing tectonic activity on the Moon. Here we assess boulder populations associated with 1116 wrinkle ridge segments on the lunar maria that are inferred to be recently active (<1.5 Ga) based on their crisp morphologies and crosscutting relationships with small impact craters. We utilize data from the Lunar Reconnaissance Orbiter Mini-RF and Diviner Lunar Radiometer Experiment instruments to assess surface rock populations across these recently active structures. Our results indicate that, where present, meter-scale boulder fields are likely indicators of fault-slip-induced ground acceleration given the short lifespan of lunar surface boulders. However, elevated boulder populations are not observed on all recently active ridges analyzed here. This latter observation supports the notion that wrinkle ridge boulder fields are a nonunique indicator of recent tectonic activity. Furthermore, the spatial distribution of those boulder fields indicates that variable mare protolith properties may play a role in boulder field formation.
The Role of Coinhibitory Receptors in B Cell Dysregulation in SARS-CoV-2–Infected Individuals with Severe Disease
Authors: Saito Suguru , Bozorgmehr Najmeh , Sligl Wendy , Osman Mohammed , Elahi Shokrollah 
Published: March 2024

Abstract
Severe SARS-CoV-2 infection is associated with significant immune dysregulation involving different immune cell subsets. In this study, when analyzing critically ill COVID-19 patients versus those with mild disease, we observed a significant reduction in total and memory B cell subsets but an increase in naive B cells. Moreover, B cells from COVID-19 patients displayed impaired effector functions, evidenced by diminished proliferative capacity, reduced cytokine, and Ab production. This functional impairment was accompanied by an increased apoptotic potential upon stimulation in B cells from severely ill COVID-19 patients. Our further studies revealed the expansion of B cells expressing coinhibitory molecules (PD-1, PD-L1, TIM-1, VISTA, CTLA-4, and Gal-9) in intensive care unit (ICU)–admitted patients but not in those with mild disease. The coinhibitory receptor expression was linked to altered IgA and IgG expression and increased the apoptotic capacity of B cells. Also, we found a reduced frequency of CD24hiCD38hi regulatory B cells with impaired IL-10 production. Our mechanistic studies revealed that the upregulation of PD-L1 was linked to elevated plasma IL-6 levels in COVID-19 patients. This implies a connection between the cytokine storm and altered B cell phenotype and function. Finally, our metabolomic analysis showed a significant reduction in tryptophan but elevation of kynurenine in ICU-admitted COVID-19 patients. We found that kynurenine promotes PD-L1 expression in B cells, correlating with increased IL-6R expression and STAT1/STAT3 activation. Our observations provide novel insights into the complex interplay of B cell dysregulation, implicating coinhibitory receptors, IL-6, and kynurenine in impaired B cell effector functions, potentially contributing to the pathogenesis of COVID-19.
ZNAČENJE EDUKACIJE ZA IMPLEMENTACIJU PRAVA DECE U ZDRAVSTVENOJ ZAŠTITI
Authors: Milošević Jasmina 
Published: March 2024

Uvod: Implementacija prava dece u zdravstvenoj zaštiti u smislu pravilne primene u praksi predstavlja uvođenje novih standarda i potrebu za dodatnom edukacijom zdravstvenih profesionalaca, dece i njihovih roditelja.
Cilj: Cilj ovog istraživačkog rada je ukazivanje na neophodnost svakodnevne primene dečijih prava u pedijatrijskoj praksi.
Metodologija: Uzorak je činilo 104 roditelja dece-pacijenata i 69 zdravstvenih radnika i saradnika koji rade sa decom pri KBC „Dr Dragiša Mišović-Dedinje“.
Rezultati: Rezultati istraživanja o informisanosti roditelja o pravima dece u sistemu zdravstvene zaštite ukazuju da veoma veliki procenat roditelja, čak 77,9%, nema adekvatnu informisanost o pravima dece u sistemu zdravstvene zaštite. Podaci o potrebi edukovanja dece i roditelja, pokazuju da 91,3% roditelja smatra da je edukacija potrebna dok njih 3,8% ima mišljenje da takva vrsta edukacije nije potrebna. Može se uočiti da velika većina zdravstvenih radnika i saradnika, 78,3% nema adekvatna znanja o pravima dece pacijenata.
Zaključak: Naše istraživanje dečijih prava i pravnog položaja dece u sistemu zdravstvene zaštite u Republici Srbiji u ovom radu ukazuje na značaj i potreba za uvođenjem novih standarda, dodatnu edukaciju dece, njihovih roditelja i zdravstvenih radnika i saradnika.
THE FISCAL POLICY OF GREECE AND ITS MACROECONOMIC PERFORMANCE WITHIN THE FRAMEWORK OF THE EUROPEAN ECONOMIC UNION
Authors: Antonopoulou Konstantina 
Published: March 2024

<p>This study aims to approach Greece's fiscal policy and its macroeconomic performance within the framework of the European Economic Union. In economics and political science fiscal and monetary policy are the basic tools used by the government and the central bank of a country respectively for the effective exercise of power, the promotion of economic goals, and the economic development of the country. The methodology followed was the review of international and domestic literature and the econometric analysis in the form of multiple linear regression between the GDP as a dependent variable and the remaining fundamental macroeconomic variables as independent variables for Greece for the period 1995-2022. The results can contribute to drawing useful conclusions about the effect of the main macroeconomic variables in particular inflation, unemployment, public debt, government expenditure, and total tax revenues on the Greek GDP.</p><p> </p><p><strong>JEL</strong>: Ε62; Η5; Η6; Ο11; Ο23</p><p> </p><p><strong> Article visualizations:</strong></p><p><img src="/-counters-/soc/0155/a.php" alt="Hit counter" /></p>
EXPLORING MORAL AND ETHICAL PRINCIPLES THROUGH DRAMA: A STUDY OF IFEYINWA UZONDU'S WHICH WAY IS RIGHT?
Authors: Akaenyi Nkiruka Jacinta 
Published: March 2024

This study delves into the exploration of moral and ethical principles through the dramatic lens, with a specific focus on Ifeyinwa Uzondu's play titled Which Way is Right? In contemporary society, the erosion of moral principles has become a pressing concern. The decline in ethical values, societal norms, and the erosion of moral boundaries have led to various social issues, impacting individuals, families, and communities. Literature, particularly drama, has often been a medium through which society reflects on its values and seeks to restore or reshape them. Ifeyinwa Uzondu's play, Which Way is Right?, explores themes related to moral dilemmas, societal norms, and the consequences of one's actions. The theoretical framework employed in this research draws from moral philosophy, ethical theories, and dramatic literature analysis. By examining the intricacies of Uzondu's play, the study aims to elucidate how drama serves as a powerful medium to engage with and interrogate moral and ethical dilemmas. The methodology involves a comprehensive textual analysis of Which Way is Right? to identify and dissect key moral and ethical themes. The findings illuminate the effectiveness of Uzondu's artistic choices in conveying complex moral dilemmas to the audience. In conclusion, this research makes a noteworthy contribution to knowledge by expanding our understanding of the moral dimensions of dramatic literature and the capacity of theatre to foster ethical awareness. It underscores the importance of engaging with art as a means of grappling with and understanding the intricacies of moral decision-making.<p> </p><p><strong> Article visualizations:</strong></p><p><img src="/-counters-/edu/0758/a.php" alt="Hit counter" /></p>
THE PHILOSOPHY OF BAUDLER'S POETRY
Authors: Peruničić Andrea 
Published: March 2024

This paper explores the poetics of Charles Baudelaire, one of the key figures of French symbolism, through the analysis of his poetic actions, themes, and influences. Baudelaire, known for his vision of a modern world shrouded in dark melancholy and despair, creates a poetic universe that transcends traditional aesthetic norms and lays the foundations of symbolist aesthetics. Through the analysis of Baudelaire's verses, we discover the complex relationship between beauty and evil, as well as the deep melancholy that permeates his poetry. Baudelaire's relationship to man and his view of human nothingness and conflict with the world are also explored, and thus we mark the inseparable connection between poetry and philosophy. Through the use of symbolic language and metaphors, Baudelaire creates poetic images that express existential anxiety and the inner struggle of man with himself. In addition, we analyze the role of poets in the development of Marxist aesthetics and political thought. Through it all, his poetry is a complex, deeply introspective, and universally relevant body of art, as summarized in the book Flowers of Evil, which continues to inspire and provoke readers around the world.<p> </p><p><strong> Article visualizations:</strong></p><p><img src="/-counters-/soc/0758/a.php" alt="Hit counter" /></p>
DEVELOPING HUMAN RESOURCES OF ETHNIC MINORITIES IN MOUNTAINOUS AREAS OF VIETNAM FACING THE CHALLENGES OF THE 4.0 INDUSTRIAL REVOLUTION
Authors: Nguyen Tran Cao , Giap Le Van , Hanh Tran Thi 
Published: March 2024

Developing human resources for ethnic minorities is essential to successfully carry out socio-economic development tasks for mountainous and ethnic minority areas. The development of modern technologies in the fourth industrial revolution has fragmented the labor market with increasing demands for the quality of the workforce if they need to be better equipped to acquire new skills - creative skills. Training human resources to meet the requirements of the 4.0 industrial revolution has become an urgent issue that many countries worldwide are concerned about, including the human resources of ethnic minorities. Therefore, developing human resources for ethnic minorities in mountainous areas of Vietnam is an urgent issue that requires feasible strategies and solutions to meet the requirements and challenges of the revolution industry 4.0.<p> </p><p><strong> Article visualizations:</strong></p><p><img src="/-counters-/lit/0756/a.php" alt="Hit counter" /></p>
E-GOVERNANCE IN REVENUE COLLECTION AND CUSTOMS ADMINISTRATION IN SIERRA LEONE – A SURVEY
Authors: Akinyosoye-Gbonda Oludolapo O. 
Published: March 2024

The willingness of taxpayers to comply with their obligations depends to a large extent upon the perception that the funds collected are put to good use. It also depends on how easy and convenient it is for the taxpayer to comply. Hence getting taxpayers to voluntarily pay their correct taxes at the right time is the dream of every government. The four key research objectives are: to find out whether the implementation of ICT will improve the performance of public enterprises; to investigate whether there is a link between the tax filing system and revenue collection; to determine the significance of tax compliance and performance of the National Revenue Authority (NRA) and to examine the relationship between tax administration and revenue collection. Data was collected through questionnaires from selected tax administrators and taxpayers in Freetown and two provincial locations, Bo and Makeni, using convenience sampling. Descriptive statistical analysis techniques were employed for data analysis. Findings from the study revealed that a vast majority of the respondents believe that the implementation of ICT results in better performance of public enterprises; and that there is a link between the tax filing system and revenue collection which allows refunds to be deposited directly into taxpayers' bank accounts; the level of tax compliance is significant to the performance of the National Revenue Authority; and adoption of ICT has positive impact on a country’s tax collection rate. The paper recommends that the Government of Sierra Leone should embark on public sensitisation on the benefits of the adoption and use of ICT infrastructure that aids easy tax administration and collection in the other rural regions of the country.<p> </p><p><strong> Article visualizations:</strong></p><p><img src="/-counters-/soc/0758/a.php" alt="Hit counter" /></p>
MODEL OF CHEATING IN A ROMANTIC RELATIONSHIP
Authors: Gono Jr. Exequiel R. 
Published: March 2024

This study aimed to investigate the likelihood of cheating in a romantic relationship using predictive modeling techniques. The researchers collected data from 500 respondents who completed the Hendrick and Hendrick's Theory of Love survey questionnaire. The results indicated that friendship love received the highest mean score, while possessive love received the lowest. Sex, religion, and education are significantly associated with cheating. The researchers utilized the age and types of love as predictors in an empirical analysis of cheating in a romantic relationship. The model demonstrated a good fit and accurately represented the data. Age and altruistic love were significant predictors of cheating, while passionate and friendship love reduced the likelihood of cheating. Altruistic love contributed the most to cheating among the types of love. The findings suggest that individuals who are older and have a stronger inclination towards altruistic love are more likely to cheat in a romantic relationship. Conversely, those with a greater degree of friendship and passionate love are less likely to engage in cheating. These results underscore the importance of understanding the different types of love in predicting infidelity in a romantic relationship.<p> </p><p><strong> Article visualizations:</strong></p><p><img src="/-counters-/soc/0718/a.php" alt="Hit counter" /></p>
Effect of Mentorship on Performance of Mission Hospitals in Kenya
Authors: Awino Peter , Juma Dennis , Eshiteti Stephen 
Published: March 2024

Purpose: Those who employ creative leadership tend to do so by creating conditions which promote creativity. Creating such conditions are described as psychological, material, and/or social supports that trigger, enable, and sustain creative thinking in others. The study sought to establish the effect of mentorship creative leadership practice on performance of mission hospitals in Kenya and to establish the moderating effect of perceived organizational support on the effect of mentorship creative leadership practice on performance of mission hospitals in Kenya.
Methodology: The study was grounded on servant leadership theory and Transactional Leadership Theory. The cross-sectional survey design was used as the study design with the positivist philosophy also being adopted. The sample populations comprised 285 Mission hospital staff at middle or lower levels of employment selected through census. Questionnaire was the main data collection instruments. This was tested for validity and reliability before being used for the study. Collected data was analyzed quantitatively using SPSS 24th version software and was presented in the form of descriptive and inferential results. Descriptive statistics involved percentages, means and means of Standard deviations while inferential involved linear regression analysis. The study results were presented through use of tables and figures
Findings: The findings of the study underscore the substantial influence of effective mentorship in enhancing both individual and organizational performance in the context of Mission hospitals in Kenya. The strong agreement among respondents on the various aspects of mentorship, combined with the significant statistical correlation between mentorship and improved hospital performance, underscores the value of investing in robust mentorship programs. Perceived organizational support moderates the effect of mentorship on performance of Mission hospitals in Kenya.
Unique Contribution to Theory, Practice and Policy: The study recommends that healthcare institutions prioritize the development and enhancement of mentorship programs. These programs should focus on leadership development, skill acquisition, and professional growth, tailored to the diverse needs of individual employees. From the study, Mentorship could explain upto 63.1% of the performance of mission hospitals in Kenya. This study therefore recommends further study on other factors affecting performance of mission hospitals in Kenya.
Comprehending Qualifying Payment Amount (QPA) and the No Surprise Act in Healthcare
Authors: Koranchirath Nithin Narayan 
Published: March 2024

Purpose: This article investigates the No Surprise Act, a pivotal piece of legislation designed to protect consumers from unexpected out-of-network healthcare charges, emphasizing the Qualifying Payment Amount (QPA) mechanism.
Methodology: Through a comprehensive literature review, analysis of legislative texts, and examination of case studies, this study elucidates the Act's origins, objectives, and operational framework of the QPA. It also explores the challenges of implementing the Act, its impact on various stakeholders (patients, healthcare providers, and insurers), and the broader implications for the U.S. healthcare system. Despite its intentions to curb surprise billing practices, the No Surprise Act and its QPA component face several implementation challenges, including administrative burdens, disputes over payment calculations, and unintended consequences on insurance premiums and healthcare market dynamics. This article leverages recent data, expert opinions, and comparative analysis with other healthcare models to provide a nuanced evaluation of the Act's effectiveness and areas for improvement.
Findings: The findings suggest that while the No Surprise Act represents a significant step forward in patient financial protection, ongoing adjustments and policy refinements are essential for achieving its intended outcomes without compromising the sustainability of healthcare providers and insurers.
Unique Contributor to Theory, Policy and Practice: Study and policy recommendations aims to contribute to the ongoing dialogue and efforts to enhance patient protection and healthcare affordability in the U.S., ensuring that the No Surprise Act lives up to its promise and potential..
FORMULATION, DEVELOPMENT AND IN VITRO EVALUATION OF TASTE MASKING MOUTH DISSOLVING TABLET OF LEVOCETIRIZINE DIHYDROCHLORIDE
Authors: Agarwal Shivendra , Misra Raghvendra , Gautam Girendra Kumar 
Published: March 2024

Levocetirizine dihydrochloride is a selective, long acting peripheral H1receptor antagonist. Allergic rhinitis is a symptomatic disorder of the nose induced by inflammation mediated by immunoglobulin E (IgE) in the membrane lining the nose after allergen exposure. Thus formulating Levocetirizine into an mouth dissolving tablet dosage form would provide fast relief. The Levocetirizine is bitter in taste so the Kyron T-114 (ion exchange resin) was used to mask the taste and to formulate an mouth dissolving tablet dosage form using drug resin complex. The tablets were evaluated for the drug content, weight variation, water absorption ratio, wetting time, in vitro disintegration, dispersion time, hardness, friability, thickness uniformity. The tablets disintegrated in vitro within 22 to 66 seconds complete drug were released from tablet within 10 minutes.
An overview of Quinazolines: Applicability of molecular docking in Cancer therapy
Authors: Yadav Manoj Kumar , Prasad Triloki , Rathi Rubal , Kushwaha Vivek Kumar , Kumar Vinay , Yadav Sachin Kumar , Kumar Deepak , Rai Satyam 
Published: March 2024

Medicinal chemistry is distracted with the elaboration, discovery, confirmation of physical and chemical approaches, and the synthesis in laboratory. Quinazoline derivatives occupy crucial positions in modern medicinal chemistry and possess established application as medicine. Several researches have been accomplished on derivatives of the quinazoline for different many pharmacological activity are reported recently. The most important process molecular docking modification is the preliminary step in the drug designing of novel drugs. The main aim of this review is to quiz or examine recently molecular docking strategies used in medicinal chemistry and in the drug discovery, Investigating the advancement in the field of computer aided drug design, and important role play through the ligand-based method. The drug discovery and the field of CADD is fast flourishing area that has seen various successes. Several giant pharmaceutical industries, in additionally to academia, adopt computer aided drug design and discovery for drug lead discovery.
Quality By Design: Concept and Applications
Authors: Raikwar Ankita 
Published: March 2024

Quality by design it is an approach in order to achieve quality of product in terms of customer satisfaction for pharmaceuticals. By this review we just summarised concept of quality, which is basically concerned with reliability, timely performance and economic of product. According to Sir Joseph Moses Juran “Quality could be planned and most quality associated problems have their origin in the way in which quality was planned in first place. It is based on ICH guidelines Q8 for pharmaceutical development, Q9 for quality risk management,Q10 for pharmaceutical quality system. It also compares between product quality by end product testing and by quality design. USFDA has consistently working on this matter in order to implement them on pharmaceutical industry. QbD advantages involves robustness of process, successful completion, scope for invention, enhanced understanding of method besides advantages, several disadvantages associated are internal unwillingness of industries, lack of belief in business core more time to file for generic products lack of technology to implemen