bluuebunny/crossref_metadata_2025_split huggingface dataset:
Loss of human leucocyte antigen class I and gain of class II expression are early events in carcinogenesis: clues from a study of Barrett’s oesophagus
Authors: Rajendra S , Ackroyd R , Karim N , Mohan C , Ho J J , Kutty M K 
Published: February 2006

Background:Human leucocyte antigen (HLA) expression is altered in oesophageal carcinomas compared with normal tissue. It is unclear, however, whether this phenotype precedes malignant transformation or results as a consequence of it.Aim:To investigate HLA class I and II expression in Barrett’s oesophagus and normal squamous oesophageal tissue.Methods:Asian patients with Barrett’s oesophagus (n = 64) and a control group (n = 60) with a normal oesophagus but without reflux symptoms were recruited using endoscopic and histopathological criteria. Tissue samples were stained with monoclonal antibodies specific for HLA-ABC, HLA-DR α chain or HLA-DP/DQ/DR, and scored semiquantitatively. The results of immunohistochemical staining were correlated with clinical and histopathological characteristics of patients.Results:Marked expression of HLA-ABC was observed in 50% of Barrett’s oesophagus sections as compared with 68.3% of controls (p = 0.038). HLA-DR staining was seen in 51.6% of Barrett’s oesophagus samples versus 11.7% of controls (p<0.001). Expression of HLA-DP/DQ/DR was evident in 73.4% of oesophageal intestinal metaplasia tissue as opposed to 18.3% of controls (p<0.001). Importantly, a total loss of HLA-ABC and a concomitant gain of HLA-DP/DQ/DR expression were seen in 37.5% of patients with Barrett’s oesophagus but in none of the controls (p<0.001). Interestingly, this phenotype was associated positively with dysplasia (adjusted p, p* = 0.031) but negatively with non-steroidal anti-inflammatory drug use (p* = 0.004).Conclusions:HLA class I expression is down regulated and class II expression is up regulated in Barrett’s oesophagus. As these changes predate malignant transformation, altered major histocompatibility complex expression may be a key event in disease progression, possibly in facilitating evasion from immune surveillance.
Rectal adenocarcinoma with oncocytic features: possible relationship with preoperative chemoradiotherapy
Authors: Rouzbahman M , Serra S , Chetty R 
Published: February 2006

Background:The introduction of preoperative chemoradiation into the treatment protocol of rectal adenocarcinomas has affected the microscopical morphology in subsequent resection specimens. The constellation of histopathological changes is varied and well documented.Aim:To describe oncocytic change in rectal cancers that have been treated with chemoradiation before surgery.Methods:7 of 54 patients with rectal cancer were identified with a history of chemoradiation, specifically directed to the rectal tumours in fractions of 4500–5000 cGy of radiation and 5-fluorouracil. The rectal tumours in five of these seven patients were composed of oncocytes that constituted 30–80% of the cancers. The patients were three men and two women aged 65–73 years, all with T3 N0 tumours. The intervals between chemoradiation and resection varied from 3 to 12 weeks.Results:The tumour cells conformed to oncocytes morphologically (large size with abundant, granular eosinophilic cytoplasm, vesicular nuclei and prominent acidophilic nucleoli), immunohistochemically (positive for carcinoembryonic antigen, cytokeratin 20 and caudal type homeo box transcription factor 2, but negative for both chromogranin and synaptophysin) and ultrastructurally (large cells showing tight junctions, cytoplasmic engorgement by mitochondria and absence of neurosecretory granules).Conclusions:The changes in these cells differ from those described previously in endocrine cells encountered in pretreated rectal cancers. Oncocytic change in this particular clinical context occurs as a reflection of cytotoxic damage or cellular hypoxia induced by chemoradiation resulting in degeneration of the cell and the oncocytic phenotype. Oncocytic change may be an under-recognised histopathological change in rectal cancers receiving preoperative chemoradiation.
The French National Mesothelioma Surveillance Program
Authors: Goldberg M , Imbernon E , Rolland P , Soit Ilg A Gilg , Savès M , de Quillacq A , Frenay C , Chamming’s S , Arveux P , Boutin C , Launoy G , Pairon J C , Astoul P , Galateau-Sallé F , Brochard P 
Published: February 2006

Objectives:The French National Mesothelioma Surveillance Program (NMSP) was established in 1998 by the National Institute for Health Surveillance (InVS). Its objectives are to estimate the trends in mesothelioma incidence and the proportion attributable to occupational asbestos exposure, to help improve its pathology diagnosis, to assess its compensation as an occupational disease, and to contribute to research.Methods:The NMSP records incident pleural tumours in 21 French districts that cover a population of approximately 16 million people (a quarter of the French population). A standardised procedure of pathological and clinical diagnosis ascertainment is used. Lifetime exposure to asbestos and to other factors (man made mineral fibres, ionising radiation, SV40 virus) is reconstructed, and a case-control study was also conducted. The proportion of mesothelioma compensated as an occupational disease was assessed.Results:Depending on the hypothesis, the estimated number of incident cases in 1998 ranged from 660 to 761 (women: 127 to 146; men: 533 to 615). Among men, the industries with the highest risks of mesothelioma are construction and ship repair, asbestos industry, and manufacture of metal construction materials; the occupations at highest risk are plumbers, pipe-fitters, and sheet-metal workers. The attributable risk fraction for occupational asbestos exposure in men was 83.2% (95% CI 76.8 to 89.6). The initial pathologist’s diagnosis was confirmed in 67% of cases, ruled out in 13%, and left uncertain in the others; for half of the latter, the clinical findings supported a mesothelioma diagnosis. In all, 62% applied for designation of an occupational disease, and 91% of these were receiving workers’ compensation.Conclusions:The NMSP is a large scale epidemiological surveillance system with several original aspects, providing important information to improve the knowledge of malignant pleural mesothelioma, such as monitoring the evolution of its incidence, of high risk occupations and economic sectors, and improving pathology techniques.
HIGH PRECISION RING LOCATION FOR A NEW ROTATIONALLY SYMMETRIC TRIANGULATION SENSOR
Authors: GAO JUN , WANG XIAOJIA , ECKSTEIN JOHANNES , OTT PETER 
Published: February 2006

For a growing range of optical measurement task, like gap measurement in automotive industry, traditional triangulation sensors have several disadvantages due to the fact that the measurement result is dependent on the orientation of the sensor because of the non-rotational symmetry of the optics. Consequently a design method was proposed recently for a new class of rotationally symmetric triangulation sensors. Such designs can be realized with aspheric reflection optics and area detectors, such as CCD or CMOS. The optics of the sensor can be extended by an imaging optics which allows at the same time image capturing and distance measurement. In this paper we show the first prototype. This system is based on an optical system of one part manufactured by commercially available diamond turning. The layout of the optical system for distance measurement consists of two reflecting aspheric surfaces. The high precision algorithm for ring location was needed because the performance of the sensor is based on the detection of ring, especially the radius of the ring. In this paper, we try to give the different evaluation function for high precision location of ring. Then we used various methods to solve it and got optimized result. The comparison of algorithms for simulation was listed in the paper. And the measurement result for the real image got by the prototype was also presented. It seems the algorithm meets the precision demand of the sensor.
Locating Nganiyo: Divination as Intentional Space
Authors: Graw Knut 
Published: February 2006

AbstractIn Senegal and Gambia, the main reason for divinatory consultation is seen not in misfortune or uncertainty but in the client's intention, longing and desire (nganiyo). To locate this intention is the diviner's first task. Successfully executed, it is the proof of his/her divinatory capacities. Drawing on the phenomenological and semantic analysis of Senegambian divinatory praxis, especially among Mandinka speakers, it is argued that Senegambian divination should not be seen as an abstract search for knowledge but as a performative praxis constituting an intentional and empowering cultural space that allows the subject to engage actively with his current situation. In a parallel analysis, it is shown that the notions and concepts underlying the divinatory process form in themselves a highly instructive theory of intentionality and affliction.
Coexistence and/or Confrontation?: Towards a Reappraisal of Christian-Muslim Encounter in Contemporary Ethiopia
Authors: Ahmed Hussein 
Published: February 2006

AbstractThis article deals with the genesis and development of Christian-Muslim relations in Ethiopia from the earliest times to the present, with an emphasis on the post-1974 developments in the country. It seeks to demonstrate that these relations were both consensual and conflictual, and that the conventional over-emphasis on the former has obscured—and marginalized and distorted—the occasional confrontational aspects of the relations that also need to be historicized, contextualized and assessed. Examples of both aspects of relations are presented and discussed, and their relevance to the contemporary situation analyzed. In summary, the paper challenges the validity of the concept of peaceful coexistence as the only defining feature of the relations between the Christian and Muslim communities of Ethiopia.
The Hidden Order of Preformation: Plans, Functions, and Hierarchies in the Organic Systems of Louis Bourguet, Charles Bonnet and Georges Cuvier
Authors: Cheung Tobias 
Published: February 2006

AbstractIn eighteenth-century French natural history, the notion of preformation was not only a model for a small preexisting embryo that gradually extended its shape through the influx of particles, but also for an order that coordinated the dynamic relation between organic parts. Preformation depended therefore also on a hidden order behind the continuity of visible forms. Louis Bourguet, Charles Bonnet, and Georges Cuvier distinguished three organizational levels: First, the synchronic or functional order of organic systems; second, the diachronic order of the initiation of mechanical processes; and third, the hierarchical order that regulates the interaction of organic parts. In this essay, I reconstruct and compare the three organizational levels in the writings of Bourguet, Bonnet and Cuvier, relate their models of organic unity to the principle of perfection, and contrast these models with Georges Buffon's critique of system theories.
Who Invented 'Avicenna's Gilded Pills'?
Authors: Bela Zbigniew 
Published: February 2006

AbstractThis article questions the belief expressed in various histories of pharmacy that the tenth-century Arab physician Avicenna introduced the tradition of coating pills with gold and silver. Although an examination of his Canon documents Avicenna's interest in the medicinal application of gold and silver, no mention is made of coating pills. Nor do other Islamic physicians seem to have been familiar with this practice, any more than such medieval European authors as Arnaldus of Villanova, Raymund Lull or Johannes de Rupescissa. The same is true of medicinal compendia representative of later periods, such as the Ortus sanitatis, Valerius Cordus' Dispensatorium or the Secrets of Alessio Piemontese. The earliest known mention of coating pills with precious metals occurs in a non-medical book, The Golden Fleece (London, 1626), and the earliest mention in the professional literature seems to appear only in the second half of the seventeenth century. The practice of coating pills with gold and silver was to be practiced in Europe into the first half of the twentieth century.
Ludwig Edelstein at the Crossroads of 1933. On the Inseparability of Life, Work, and Their Reverberations
Authors: Rütten Thomas 
Published: February 2006

AbstractThis article takes some first steps towards the establishment of the intellectual biography of the medical historian, classicist, and moral philosopher Ludwig Edelstein (1902-1965). Based on scattered archival records, it sheds light on Edelstein's early career in Germany, the decisions he was forced to make in 1933 when he left Germany and the events that led to his appointment as associate professor at Baltimore's Johns Hopkins University in the autumn of 1934. The representative nature of Edelstein's case will be highlighted in terms of both the history of exile and the history of the academic disciplines involved (medical history and classics); in doing so, the article attempts to reinscribe Edelstein's achievements and influence back into their respective discourses.
A Mechanism for Abrupt Climate Change Associated with Tropical Pacific SSTs*
Authors: Vavrus Steve , Notaro Michael , Liu Zhengyu 
Published: February 2006

Abstract
The tropical Pacific’s response to transiently increasing atmospheric CO2 is investigated using three ensemble members from a numerically efficient, coupled atmosphere–ocean GCM. The model is forced with a 1% yr−1 increase in CO2 for 110 yr, when the concentration reaches 3 times the modern concentration. The transient greenhouse forcing causes a regionally enhanced warming of the equatorial Pacific, particularly in the far west. This accentuated equatorial heating, which is slow to arise but emerges abruptly during the last half of the simulations, results from both atmospheric and oceanic processes. The key atmospheric mechanism is a rapid local increase in the super–greenhouse effect, whose emergence coincides with enhanced convection and greater high cloud amount once the SST exceeds an apparent threshold around 27°C. The primary oceanic feedback is greater Ekman heat convergence near the equator, due to an anomalous near-equatorial westerly wind stress created by increased rising (sinking) air to the east (west) of Indonesia. The potential dependence of these results on the specific model used is discussed.
The suddenness and far-ranging impact of the enhanced, near-equatorial warming during these simulations suggests a mechanism by which abrupt climate changes may be triggered within the Tropics. The extratropical atmospheric response in the Pacific resembles anomalies during present-day El Niño events, while the timing and rapidity of the midlatitude changes are similar to those in the Tropics. In particular, a strengthening of the Pacific jet stream and a spinup of the wintertime Aleutian low seem to be forced by the changes in the tropical Pacific, much as they are in the modern climate.
Dipole Anomaly in the Winter Arctic Atmosphere and Its Association with Sea Ice Motion
Authors: Wu Bingyi , Wang Jia , Walsh John E. 
Published: February 2006

Abstract
This paper identified an atmospheric circulation anomaly–dipole structure anomaly in the Arctic atmosphere and its relationship with winter sea ice motion, based on the International Arctic Buoy Program (IABP) dataset (1979–98) and datasets from the National Centers for Environmental Prediction (NCEP) and the National Center for Atmospheric Research (NCAR) for the period 1960–2002. The dipole anomaly corresponds to the second-leading mode of EOF of monthly mean sea level pressure (SLP) north of 70°N during the winter season (October–March) and accounts for 13% of the variance. One of its two anomalous centers is stably occupied between the Kara Sea and Laptev Sea; the other is situated from the Canadian Archipelago through Greenland extending southeastward to the Nordic seas. The dipole anomaly differs from one described in other papers that can be attributed to an eastward shift of the center of action of the North Atlantic Oscillation. The finding shows that the dipole anomaly also differs from the “Barents Oscillation” revealed in a study by Skeie. Since the dipole anomaly shows a strong meridionality, it becomes an important mechanism to drive both anomalous sea ice exports out of the Arctic Basin and cold air outbreaks into the Barents Sea, the Nordic seas, and northern Europe.
When the dipole anomaly remains in its positive phase, that is, negative SLP anomalies appear between the Kara Sea and the Laptev Sea with concurrent positive SLP over from the Canadian Archipelago extending southeastward to Greenland, there are large-scale changes in the intensity and character of sea ice transport in the Arctic basin. The significant changes include a weakening of the Beaufort gyre, an increase in sea ice export out of the Arctic basin through Fram Strait and the northern Barents Sea, and enhanced sea ice import from the Laptev Sea and the East Siberian Sea into the Arctic basin. Consequently, more sea ice appears in the Greenland and the Barents Seas during the positive phase of the dipole anomaly. During the negative phase of the dipole anomaly, SLP anomalies show an opposite scenario in the Arctic Ocean and its marginal seas when compared to the positive phase, with the center of negative SLP anomalies over the Nordic seas. Correspondingly, sea ice exports decrease from the Arctic basin flowing into the Nordic seas and the northern Barents Sea because of the strengthened Beaufort gyre.
The finding indicates that influences of the dipole anomaly on winter sea ice motion are greater than that of the winter AO, particularly in the central Arctic basin and northward to Fram Strait, implying that effects of the dipole anomaly on sea ice export out of the Arctic basin become robust. The dipole anomaly is closely related to atmosphere–ice–ocean interactions that influence the Barents Sea sector.
A prospective study of the natural history of transient leukemia (TL) in neonates with Down syndrome (DS): Children's Oncology Group (COG) study POG-9481
Authors: Massey Gita V. , Zipursky Alvin , Chang Myron N. , Doyle John J. , Nasim Suhail , Taub Jeffrey W. , Ravindranath Yaddanapudi , Dahl Gary , Weinstein Howard J. 
Published: February 2006

AbstractA unique transient leukemia (TL) has been described in newborns with Down syndrome (DS; or trisomy 21 mosaics). This leukemia has a high incidence of spontaneous remission; however, early death and subsequent development of acute megakaryoblastic leukemia (AMKL) have been reported. We prospectively evaluated 48 infants with DS and TL to determine the natural history and biologic characteristics of this disease, identify the clinical characteristics associated with early death or subsequent leukemia, and assess the incidence of subsequent leukemia. Blast cells associated with TL in DS infants exhibited FAB M7 morphology and phenotype. Most infants (74%) had trisomy 21 (or mosaicism) as the only cytogenetic abnormality in the blast cells. Most children were able to spontaneously clear peripheral blasts (89%), normalize blood counts (74%), and maintain a complete remission (64%). Early death occurred in 17% of infants and was significantly correlated with higher white blood cell count at diagnosis (P < .001), increased bilirubin and liver enzymes (P < .005), and a failure to normalize the blood count (P = .001). Recurrence of leukemia occurred in 19% of infants at a mean of 20 months. Development of leukemia was significantly correlated with karyotypic abnormalities in addition to trisomy 21 (P = .037). Ongoing collaborative clinical studies are needed to determine the optimal role of chemotherapy for infants at risk for increased mortality or disease recurrence and to further the knowledge of the unique biologic features of this TL.
Cul4A targets p27 for degradation and regulates proliferation, cell cycle exit, and differentiation during erythropoiesis
Authors: Li Binghui , Jia Nan , Kapur Reuben , Chun Kristin T. 
Published: February 2006

AbstractAs erythroid progenitors differentiate into precursors and finally mature red blood cells, lineage-specific genes are induced, and proliferation declines until cell cycle exit. Cul4A encodes a core subunit of a ubiquitin ligase that targets proteins for ubiquitin-mediated degradation, and Cul4A-haploinsufficient mice display hematopoietic dysregulation with fewer multipotential and erythroid-committed progenitors. In this study, stress induced by 5-fluorouracil or phenylhydrazine revealed a delay in the recovery of erythroid progenitors, early precursors, and normal hematocrits in Cul4A+/– mice. Conversely, overexpression of Cul4A in a growth factor-dependent, proerythroblast cell line increased proliferation and the proportion of cells in S phase. When these proerythroblasts were induced to terminally differentiate, endogenous Cul4A protein expression declined 3.6-fold. Its enforced expression interfered with erythrocyte maturation and cell cycle exit and, instead, promoted proliferation. Furthermore, p27 normally accumulates during erythroid terminal differentiation, but Cul4A-enforced expression destabilized p27 and attenuated its accumulation. Cul4A and p27 proteins coimmunoprecipitate, indicating that a Cul4A ubiquitin ligase targets p27 for degradation. These findings indicate that a Cul4A ubiquitin ligase positively regulates proliferation by targeting p27 for degradation and that Cul4A down-regulation during terminal erythroid differentiation allows p27 to accumulate and signal cell cycle exit.
Cytokine-induced IL-10–secreting CD8 T cells represent a phenotypically distinct suppressor T-cell lineage
Authors: Noble Alistair , Giorgini Angela , Leggat Jamie A. 
Published: February 2006

AbstractPopulations of regulatory T cells (Tregs) control autoimmune and allergic immunopathology induced by self or foreign antigens. Several types of CD4+ MHC class II–restricted Treg populations have been characterized, but the biology of CD8+, MHC class I–restricted Tregs is less understood. We show here that CD8+ Tregs are rapidly generated in the presence of IL-4 and IL-12, produce IL-10, and exhibit a unique cell-surface phenotype with coexpression of activation and naive cell-associated markers. They block activation of naive or effector T cells and suppress IgG/IgE antibody responses and graft-versus-host disease in vivo. Suppression is dependent on cell contact and mediated by direct T-cell–T-cell interaction that antagonizes T-cell–receptor (TCR) signals. The data establish the existence of a CD8 T-cell suppressor effector subset distinct in both phenotype and function from T cytotoxic 1 (Tc1) and Tc2 cells. Production of such CD8 Tregs has potential for cell-based therapy of CD4 or CD8 T-cell–mediated disease.