bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of Rural and Urban Residents’ Implicit and Explicit Attitudes Related to Seeking Medical Care
Authors: Harju Beverly L. , Wuensch Karl L. , Kuhl Emily A. , Cross Natalie J. 
Published: September 2006

ABSTRACT:
Context: The decision whether or not to consult a physician draws from a variety of attitudes within an individual’s health schema. While rural Americans are in greater need of health care, many of them have fewer external resources than urbanites available to them. Purpose: The objective of this study was to elicit implicit and explicit attitudes related to seeking medical treatment for a condition described as fairly serious. Participants were asked to rate how often they comply with treatment regimens and practice good health habits. Methods: The sample of rural (N = 586) and urban (N = 433) North Carolina residents was derived based on random‐digit dialing. Multiple regression analyses were performed to investigate how attitudes associated with perceived compliance and health behaviors. Findings: While rural and urban residents offered very similar responses, the associations between attitudes and behaviors were different. One healthy and 2 unhealthy schema patterns emerged. First, fear of hospitals was associated with effective compliance for rural residents and good health habits for urbanites. Second, affordability concerns were ascribed to rural community residents but seemed to reflect personally relevant implicit attitudes since they were associated with poor health adherence and habits for rural residents. Third, mistrust of doctors predicted low adherence for both groups and was also associated with poorer health habits for urbanites. With inconsistencies among implicit and explicit attitudes and behaviors, some residents seemed to be ambivalent about seeking health care.
Intrinsic Macrolide Resistance in Rapidly Growing Mycobacteria
Authors: Nash Kevin A. , Andini Nadya , Zhang Yansheng , Brown-Elliott Barbara A. , Wallace Richard J. 
Published: September 2006

ABSTRACT

This study reports the discovery of
erm
genes in seven species of rapidly growing mycobacteria (RGM):
Mycobacterium boenickei
,
M. goodii
,
M. houstonense
,
M. mageritense
,
M. neworleansense
,
M. porcinum
, and
M. wolinskyi
. This study further substantiates the role of
erm
genes in intrinsic macrolide resistance in RGM.
Intercomparison of the Southern Ocean Circulations in IPCC Coupled Model Control Simulations
Authors: Russell Joellen L. , Stouffer Ronald J. , Dixon Keith W. 
Published: September 2006

Abstract
The analyses presented here focus on the Southern Ocean as simulated in a set of global coupled climate model control experiments conducted by several international climate modeling groups. Dominated by the Antarctic Circumpolar Current (ACC), the vast Southern Ocean can influence large-scale surface climate features on various time scales. Its climatic relevance stems in part from it being the region where most of the transformation of the World Ocean’s water masses occurs. In climate change experiments that simulate greenhouse gas–induced warming, Southern Ocean air–sea heat fluxes and three-dimensional circulation patterns make it a region where much of the future oceanic heat storage takes place, though the magnitude of that heat storage is one of the larger sources of uncertainty associated with the transient climate response in such model projections. Factors such as the Southern Ocean’s wind forcing, heat, and salt budgets are linked to the structure and transport of the ACC in ways that have not been expressed clearly in the literature. These links are explored here in a coupled model context by analyzing a sizable suite of preindustrial control experiments associated with the forthcoming Intergovernmental Panel on Climate Change’s Fourth Assessment Report. A framework is developed that uses measures of coupled model simulation characteristics, primarily those related to the Southern Ocean wind forcing and water mass properties, to allow one to categorize, and to some extent predict, which models do better or worse at simulating the Southern Ocean and why. Hopefully, this framework will also lead to increased understanding of the ocean’s response to climate changes.
Improving SST Anomaly Simulations in a Layer Ocean Model with an Embedded Entrainment Temperature Submodel
Authors: Zhang Rong-Hua , Busalacchi Antonio J. , Murtugudde Raghuram G. 
Published: September 2006

Abstract
In this study, an improved sea surface temperature (SST) anomaly (SSTA) solution for the tropical Pacific is presented by explicitly embedding into a layer ocean general circulation model (OGCM) a separate SSTA submodel with an empirical parameterization for the temperature of subsurface water entrained into the ocean mixed layer (Te). Instead of using subsurface temperature directly from the OGCM, Te anomalies for the embedded SSTA submodel are calculated from a historical data-based empirical procedure in terms of sea level (SL) anomalies simulated from the OGCM. An inverse modeling approach is first adopted to estimate Te anomalies from the SSTA equation using observed SST and simulated upper-ocean currents from the OGCM. A relationship between Te and SL anomalies is then obtained by utilizing an empirical orthogonal function (EOF) analysis technique. The empirical Te parameterization optimally leads to a better balanced depiction of the subsurface effect on SST variability by the mean upwelling of anomalous subsurface temperature and vertical mixing in the equatorial Pacific. As compared with a standard OGCM simulation, SSTA simulations from the embedded submodel exhibit more realistic variability, with significantly increased correlation and reduced SSTA errors due to the optimized empirical Te parameterization. In the Niño-3 region (5°S–5°N, 150°–90°W), the anomaly correlation and root-mean-square (RMS) error of the simulated SST anomalies for the period 1963–96 from the standard OGCM are 0.74° and 0.58°C, while from the embedded SSTA submodel they are 0.94° and 0.29°C in the Te-dependent experiment, and 0.86° and 0.41°C in the experiment with one-dependent-year data excluded, respectively. Cross validation and sensitivity experiments to training periods for building the Te parameterization are made to illustrate the robustness and effectiveness of the approach. Moreover, the impact on simulations of SST anomalies and El Niño are examined in hybrid coupled atmosphere–ocean models (HCMs) consisting of the OGCM and a statistical atmospheric wind stress anomaly model that is constructed from a singular value decomposition (SVD) analysis. Results from coupled runs with and without embedding the SSTA submodel are compared. It is demonstrated that incorporating the embedded SSTA submodel in the context of an OGCM has a significant impact on performance of the HCMs and the behavior of the coupled system, with more realistic simulations of interannual SST anomalies (e.g., the amplitude and structure) in the tropical Pacific.
Precipitation Characteristics in Eighteen Coupled Climate Models
Authors: Dai Aiguo 
Published: September 2006

Abstract
Monthly and 3-hourly precipitation data from twentieth-century climate simulations by the newest generation of 18 coupled climate system models are analyzed and compared with available observations. The characteristics examined include the mean spatial patterns, intraseasonal-to-interannual and ENSO-related variability, convective versus stratiform precipitation ratio, precipitation frequency and intensity for different precipitation categories, and diurnal cycle. Although most models reproduce the observed broad patterns of precipitation amount and year-to-year variability, models without flux corrections still show an unrealistic double-ITCZ pattern over the tropical Pacific, whereas the flux-corrected models, especially the Meteorological Research Institute (MRI) Coupled Global Climate Model (CGCM; version 2.3.2a), produce realistic rainfall patterns at low latitudes. As in previous generations of coupled models, the rainfall double ITCZs are related to westward expansion of the cold tongue of sea surface temperature (SST) that is observed only over the equatorial eastern Pacific but extends to the central Pacific in the models. The partitioning of the total variance of precipitation among intraseasonal, seasonal, and longer time scales is generally reproduced by the models, except over the western Pacific where the models fail to capture the large intraseasonal variations. Most models produce too much convective (over 95% of total precipitation) and too little stratiform precipitation over most of the low latitudes, in contrast to 45%–65% in convective form in the Tropical Rainfall Measuring Mission (TRMM) satellite observations. The biases in the convective versus stratiform precipitation ratio are linked to the unrealistically strong coupling of tropical convection to local SST, which results in a positive correlation between the standard deviation of Niño-3.4 SST and the local convective-to-total precipitation ratio among the models. The models reproduce the percentage of the contribution (to total precipitation) and frequency for moderate precipitation (10–20 mm day−1), but underestimate the contribution and frequency for heavy (&gt;20 mm day−1) and overestimate them for light (&lt;10 mm day−1) precipitation. The newest generation of coupled models still rains too frequently, mostly within the 1–10 mm day−1 category. Precipitation intensity over the storm tracks around the eastern coasts of Asia and North America is comparable to that in the ITCZ (10–12 mm day−1) in the TRMM data, but it is much weaker in the models. The diurnal analysis suggests that warm-season convection still starts too early in these new models and occurs too frequently at reduced intensity in some of the models. The results show that considerable improvements in precipitation simulations are still desirable for the latest generation of the world’s coupled climate models.
Topographic Control of Basin and Channel Flows: The Role of Bottom Pressure Torques and Friction
Authors: Jackson Laura , Hughes Chris W. , Williams Richard G. 
Published: September 2006

Abstract
The topographical control of western boundary currents within a basin and zonal jets in a channel is investigated in terms of the potential vorticity (PV) and barotropic vorticity (BV: the curl of the depth-integrated velocity) budgets using isopycnic, adiabatic wind–driven experiments. Along the western boundary, the wind-driven transport is returned across latitude lines by the bottom pressure torque, while friction is only important in altering the PV within an isopycnic layer and in allowing a closed circulation. These contrasting balances constrain the geometry of the flow through integral relationships for the BV and PV. For both homogenous and stratified basins with sloping sidewalls, the northward subtropical jet separates from the western wall and has opposing frictional torques on either side of the jet, which cancel in a zonal integral for BV but alter the PV within a layer streamline. In a channel with partial topographic barriers, the bottom pressure torque is again important in returning wind-driven flows along western boundaries and in transferring BV from neighboring wind-driven gyres into a zonal jet. The depth-integrated flow steered by topography controls where the bottom friction alters the PV, which can lead to different PV states being attained for separate subbasins along a channel.
The Different Nature of the Interdecadal Variability of the Thermohaline Circulation under Mixed and Flux Boundary Conditions
Authors: Arzel Olivier , Huck Thierry , Colin de Verdière Alain 
Published: September 2006

Abstract
The differences between the interdecadal variability under mixed and constant flux boundary conditions are investigated using a coarse-resolution ocean model in an idealized flat-bottom single-hemisphere basin. Objective features are determined that allow one type of oscillation to be distinguished versus the other. First, by performing a linear stability analysis of the steady state obtained under restoring boundary conditions, it is shown that the interdecadal variability under constant flux and mixed boundary conditions arises, respectively, from the instability of a linear mode around the mean stratification and circulation and from departure from the initial state. Based on the budgets of density variance, it is shown next that the two types of oscillations have different energy sources: Under the constant-flux boundary condition (the thermal mode), the downgradient meridional eddy heat flux in the western boundary current regions sustains interdecadal variability, whereas under mixed boundary conditions (the salinity mode), a positive feedback between convective adjustment and restoring surface heat flux is at the heart of the existence of the decadal oscillation. Furthermore, the positive correlations between temperature and salinity anomalies in the forcing layer are shown to dominate the forcing of density variance. In addition, the vertical structure of perturbations reveals vertical phase lags at different depths in all tracer fields under constant flux, while under mixed boundary conditions only the temperature anomalies show a strong dipolar structure. The authors propose that these differences will allow one to identify which type of oscillation, if any, is at play in the more exhaustive climate models.
Analytical Solutions for Circular Stratified Eddies of the Reduced-Gravity Shallow-Water Equations
Authors: Dotsenko Sergey , Rubino Angelo 
Published: September 2006

Abstract
A set of new analytical nonstationary solutions of the nonlinear, reduced-gravity shallow-water equations on an f plane in a vertically stably stratified active environment is presented. The solutions, which describe the dynamics of inertially pulsating surface as well as intermediate lens-like stratified vortices, represent an extension of previous analytical solutions to more realistic vortex shapes and structures of the vortex swirl velocity fields in the presence of an arbitrary stable vertical stratification within the active environment. To elucidate aspects of the novelty of the new set of solutions, examples are presented referring to a vertically stratified surface vortex and to a vertically stratified intermediate vortex, both characterized by azimuthal velocity fields that are nonlinear functions of the radius and by layer shapes that largely deviate from paraboloidal shapes. First, a solution describing a five-layer surface “warm core” eddy is analyzed and characteristics resembling characteristics observed in geophysical surface vortices are revealed: Within each layer, the obtained azimuthal velocity shows a realistic distribution, as its maximum is located far from the vortex rim, where it is negligible. Moreover, the obtained azimuthal velocity is largest in the surface layer and decreases monotonically toward the deeper layers. Integral properties of the new stratified solutions significantly differ from the corresponding properties of equivalent, known homogeneous solutions. Significant differences are found, for instance, between the shape of a five-layer vortex and that of its homogenous counterpart having the same mean azimuthal velocity structure. Second, a solution referring to a five-layer intermediate “meddy like” vortex is analyzed: while in each layer the obtained azimuthal velocity is maximum in the interior part of the vortex and decreases toward its center and its periphery, its magnitude is largest in the intermediate layer and it decreases toward the surface and toward the bottom layer, which are characteristics resembling characteristics of observed meddies. The quoted examples demonstrate that the new solutions add substantial realism to the analytical description of oceanic nonlinear geophysical vortices. In the context of the nonlinear reduced-gravity shallow-water equations on an f plane they seem to represent the most general analytical features achievable, which refer to vertically stratified circular vortices characterized by linear radial velocity fields.
Seconding healthcare assistants to a pre-registration nursing course
Authors: Gould Dinah , Carr Graham , Kelly Daniel 
Published: September 2006

Attrition from traditional pre-registration nursing programmes in the United Kingdom continues to be substantial and, once qualified, new staff nurses experience a number of challenges in adapting to their new role. A possible solution, strongly favoured by the current government, is to second existing healthcare assistants onto pre-registration programmes. The premise is that, because of their previous caring experience and exposure to work in the National Health Service, secondees will be more committed to complete training and will undergo role transition more effectively. This paper presents an in-depth, qualitative study concerning the role transition of newly qualified staff nurses who had previously been employed as healthcare assistants. Uptake of the scheme had been substantially lower than anticipated, with only a small number of secondees eventually returning to their original wards. Secondees, their ward managers, percerptors and clinical practice facilitators were interviewed and the data were analysed employing the sequence for qualitative data analysis described by Miles and Huberman (1994). Findings suggest that healthcare-assistant secondment may not offer a ready solution to increasing the qualified nursing workforce. Contributory factors include: the length of time required for each newly qualified practitioner to qualify via the secondment route; the degree of commitment required on the part of secondees and university staff; the apparently limited benefits of previous healthcare-assistant experience; and personal costs to the secondees. Secondees described how they had been afraid of not completing the course successfully because of the public nature of failure if they were obliged to return to their original workplaces in the same role as before. This additional pressure has not been anticipated by proponents of secondment schemes and may help to explain why so few eligible candidates applied for secondment.
PI3K regulates pleckstrin-2 in T-cell cytoskeletal reorganization
Authors: Bach Tami L. , Kerr Wesley T. , Wang Yanfeng , Bauman Eve Marie , Kine Purnima , Whiteman Eileen L. , Morgan Renell S. , Williamson Edward K. , Ostap E. Michael , Burkhardt Janis K. , Koretzky Gary A. , Birnbaum Morris J. , Abrams Charles S. 
Published: September 2006

Abstract
Pleckstrin-2 is composed of 2 pleckstrin homology (PH) domains and a disheveled–Egl-10–pleckstrin (DEP) domain. A lipid-binding assay revealed that pleckstrin-2 binds with greatest affinity to D3 and D5 phosphoinositides. Pleckstrin-2 expressed in Jurkat T cells bound to the cellular membrane and enhanced actin-dependent spreading only after stimulation of the T-cell antigen receptor or the integrin α4β1. A pleckstrin-2 variant containing point mutations in both PH domains failed to associate with the Jurkat membrane and had no effect on spreading under the same conditions. Although still membrane bound, a pleckstrin-2 variant containing point mutations in the DEP domain demonstrated a decreased ability to induce membrane ruffles and spread. Pleckstrin-2 also colocalized with actin at the immune synapse and integrin clusters via its PH domains. Although pleckstrin-2 can bind to purified D3 and D5 phosphoinositides, the intracellular membrane association of pleckstrin-2 and cell spreading are dependent on D3 phosphoinositides, because these effects were disrupted by pharmacologic inhibition of phosphatidylinositol 3-kinase (PI3K). Our results indicate that pleckstrin-2 uses its modular domains to bind to membrane-associated phosphatidylinositols generated by PI3K, whereby it coordinates with the actin cytoskeleton in lymphocyte spreading and immune synapse formation.
Prophylactic human granulocyte colony-stimulating factor after induction therapy in pediatric acute myeloid leukemia
Authors: Lehrnbecher Thomas , Zimmermann Martin , Reinhardt Dirk , Dworzak Michael , Stary Jan , Creutzig Ursula 
Published: September 2006

Abstract
Children with acute myelogenous leukemia (AML) have a high risk of infectious complications that might be reduced by prophylactic granulocyte colony-stimulating factor (G-CSF). However, G-CSF could induce AML blast proliferation. The prospective randomized trial AML-BFM 98 investigated the impact of G-CSF on hematopoetic recovery and infectious complications (primary endpoints) and on outcome (secondary endpoint) in children (aged 0-18 years) with de novo AML. Patients with more than 5% blasts in day-15 bone marrow or with FAB M3 were not included. Between 1998 and 2003, 161 children with AML were randomized to receive G-CSF after inductions 1 and 2, whereas 156 patients were assigned to the control group. Time of neutropenia after inductions 1 and 2 was significantly shorter in the G-CSF group (23 vs 18 days and 16 vs 11 days; P = .02 and = .001, respectively). G-CSF did not decrease the incidence of febrile neutropenia (72 and 36 patients vs 78 and 37 patients, respectively), microbiologically documented infections (27 and 25 patients vs 36 and 19 patients, respectively) and infection-associated mortality (5 vs 2 patients). Both groups had similar 5-year event-free survival (EFS; 59% ± 4% vs 58% ± 4%). Since G-CSF does not influence the risk of infectious complications or outcome in children undergoing therapy for AML, one cannot advocate the routine use of G-CSF in this patient group.
Gefitinib monotherapy in advanced nonsmall cell lung cancer: a large Western community implementation study
Authors: van Puijenbroek R. , Bosquée L. , Meert A-P. , Schallier D. , Goeminne J-C. , Tits G. , Collard P. , Nackaerts K. , Canon J-L. , Duplaquet F. , Galdermans D. , Germonpré P. , Azerad M-A. , Vandenhoven G. , De Greve J. , Vansteenkiste J. 
Published: September 2006

Epidermal growth factor receptor tyrosine kinase inhibitors represent a new treatment option for patients with advanced nonsmall cell lung cancer (NSCLC). This retrospective study examined to what extent previous clinical trial experience matches large-scale Western community implementation of this treatment.In the Belgian expanded access programme, the data from 513 patients with advanced or metastatic NSCLC, not suitable for further chemotherapy and receiving oral gefitinib 250 mg·day-1until disease progression, death or unacceptable toxicity, were analysed.The median (range) duration of gefitinib treatment was 2.3 months (0.0–32.7). Its use was predominantly in second- or third-line treatment. The overall response and disease control rates were 8.9 and 41.2%, respectively. In univariate analysis, response was more common in females and never-smokers. In multivariate analysis, female sex was the only significant predictive factor (odds ratio (OR) (95% confidence interval (CI)) 0.329 (0.129–0.839)). Symptom improvement was reported in 108 patients of whom 32 (29.6%) had an objective response, 66 (61.1%) experienced disease stabilisation and 10 (9.3%) progressed. Gefitinib was well tolerated; only 7.8% of the patients reported grade 3 or 4 toxicity. The overall median survival was 4.7 months, with a 1-yr survival rate of 21%. Survival was strongly influenced by a better performance status (PS) (good PS: hazard ratio (HR) (95%CI) 0.110 (0.077–0.157)) and adenocarcinoma with bronchioloalveolar carcinoma features histology (HR (95%CI) 0.483 (0.279–0.834)).In conclusion, the activity of gefitinib was confirmed in the present large Western community implementation study. Response, present in a small subgroup, led to a rewarding survival and could be predicted by sex only. Baseline performance status and adenocarcinoma with bronchioloalveolar carcinoma features histology were significant factors for survival.