bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gold Nanoparticle Delivery of Glut1 SiRNA Facilitates Glucose Starvation Therapy in Lung Cancer
Authors: Li Jiaqi , Yu Jingyuan , Fang Qi , Du Yan , Zhang Xiaojun 
Published: April 2024

AbstractGlucose transporter protein‐1 (Glut1), is highly expressed in many cancer types and plays a crucial role in cancer progression through enhanced glucose transport. Its overexpression is associated with aggressive tumor behavior and poor prognosis. Herein, the nucleic acids modified gold nanoparticles (AuNPs) was synthesized to deliver small interfering RNA (siRNA) against Glut1 by microRNA 21 (miR‐21) triggers toehold‐mediated strand displacement reaction for lung cancer starvation therapy. Overexpression of miR‐21 triggers toehold‐mediated strand displacement, releasing the siRNA to knockdown of Glut1 in cancer cell instead of normal cell. Furthermore, the glucose oxidase‐like activity of the AuNPs accelerates intracellular glucose consumption, promoting cancer cell starvation. The engineered AuNPs@anti‐miR‐21/siGlut1 complex inhibits cancer cell proliferation, xenograft tumor growth and promotes apoptosis through glucose starvation and ROS cascade signaling, underscoring its potential as an effective therapeutic strategy for lung cancer.
B(C6F5)3/CPA‐Catalyzed Aza‐Diels‐Alder Reaction of 3,3‐Difluoro‐2‐Aryl‐3H‐indoles and Unactivated Dienes
Authors: Wei Xing‐Pin , Wang Xin‐Chun , Ma Tao , Qiao Xiu‐Xiu , Li Ganpeng , He Yonghui , Zhao Xiao‐Jing 
Published: April 2024

AbstractHere we report B(C6F5)3/CPA‐catalyzed enantioselective aza‐Diels–Alder reaction of 3,3‐difluoro‐2‐Aryl‐3H‐indoles with unactivated dienes to access chiral 10,10‐difluoro‐tetrahydropyrido[1,2‐a]indoles. This protocol allows the formation of pyrazole‐based C2‐quaternary indolin‐3‐ones with high enantioselectivities and regioselectivities. Moreover, gram‐scale synthesis of the 10,10‐difluoro‐tetrahydropyrido[1,2‐a]indole skeleton was successfully achieved without any reduction in both yield and enantioselectivity.
Tetraanionic Oligo‐Dioxaborines: Strongly Absorbing Near‐Infrared Dyes
Authors: Polishchuk Vladyslav , Kulinich Andrii , Shandura Mykola 
Published: April 2024

AbstractPolymethine dyes of tetraanionic nature comprising 1,3,2‐dioxaborine rings in the polymethine chain and end‐groups of different electron‐accepting abilities have been synthesized. They can be considered as oligomeric polymethines, where a linear conjugated π‐system passes through three 1,3,2‐dioxaborine units and a number of tri‐ and dimethine π‐bridges between two end‐groups. The obtained dyes exhibit near‐infrared absorption and fluorescence, with molar absorption coefficients reaching as high as 564000 M−1 cm−1 in DMF, rendering them among the strongest absorbers known. The novel compounds are bright NIR fluorophores, with fluorescence quantum yields up to 0.13 in DMF. A comparative analysis of the electronic structure of the obtained dyes with respective dianionic and trianionic oligomers was conducted through quantum chemical calculations.
Investigating the CO2 injection and the performance of nanoparticles in preventing formation damage at different pressures and concentrations
Authors: Talebi Alireza , Shafiei Masoud , Escrochi Mehdi , Kazemzadeh Yousef , Riazi Masoud 
Published: April 2024

AbstractAsphaltene deposition is one of the main challenges during CO2 injection (miscible or immiscible) into reservoirs. Asphaltene deposition reduces the porosity and permeability of reservoir rock and changes its wettability to strongly oil‐wet. In this article, to control the asphaltene deposition during CO2 injection the use of direct asphaltene inhibitors (Al2O3 and Fe3O4) in reservoir conditions. In this research, nanoparticle screening (to investigate its significance in reducing asphaltene precipitation) has been done and it can be stated that Al2O3 nanoparticle will perform better effectivity than Fe3O4 nanoparticle. After that, by using effective nanoparticles (Al2O3) in different concentrations (1000 and 2000 ppm), the amount of asphaltene deposition during CO2 injection has been investigated. The obtained results show that increasing the injection pressure (from immiscible to miscible) causes an increase in asphaltene deposition and the use of nanoparticles will reduce the amount of asphaltene deposition.
Anti‐Cancer Activity of Ethanolic Extract from ‘Bao’ Mango (Mangifera indica) Peel and Its Nanoencapsulation Against Triple‐Negative Breast Cancer Cell Lines
Authors: Kumkoon Tipaporn , Chunhavacharatorn Phatchada , Manohong Preeyanuch , Nirmal Nilesh , Benjakul Soottawat , Katewongsa Kanlaya 
Published: April 2024

AbstractMango (Mangifera indica) has been one of the most cultivated fruits in Thailand and other South and Southeast Asian countries. ‘Bao’ mango is a distinct petite mango variety that is available all year round. This study aimed to investigate the antioxidant and anti‐breast cancer activities of Bao‐mango peel extract (MPE). The total phenolic content (TPC) of MPE was 280.57 ± 7.95 μg quercetin per g of powder. Based on antioxidant activity analyses, MPE had IC50values of 35.09 and 23.80 ± 0.48 μg/mL for 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH) and 2,2′‐azino‐bis‐3‐ethylbenzthiazoline‐6‐sulphonic acid (ABTS) radical scavenging activities, respectively. Additionally, MPE exerted an inhibitory action against MDA‐MB‐231 breast cancer cells with an IC50of 39.08 ± 5.22 μg/mL. Furthermore, nanoencapsules loaded with MPE using chitosan‐coated poly lactic‐co‐glycolic acid (CS‐PLGA‐(MPE)) were also prepared. It exhibited spherical morphology with an average size of 251.90 ± 19.61 nm. Encapsulation efficiency (EE) of nanoparticles was 30.48 %. Moreover, the CS‐PLGA‐(MPE) exhibited higher anticancer activity by affecting cell viability and inhibiting the cell migration and invasion of MDA‐MB‐231 breast cancer cells, compared to the free MPE. Therefore, these findings indicated that MPE and CS‐PLGA‐(MPE) nanoparticles could be promising alternatives to chemicals used for breast cancer treatment.
h5bench: A unified benchmark suite for evaluating HDF5 I/O performance on pre‐exascale platforms
Authors: Bez Jean Luca , Tang Houjun , Breitenfeld Scot , Zheng Huihuo , Liao Wei‐Keng , Hou Kaiyuan , Huang Zanhua , Byna Suren 
Published: April 2024

SummaryParallel I/O is a critical technique for moving data between compute and storage subsystems of supercomputers. With massive amounts of data produced or consumed by compute nodes, high‐performant parallel I/O is essential. I/O benchmarks play an important role in this process; however, there is a scarcity of I/O benchmarks representative of current workloads on HPC systems. Toward creating representative I/O kernels from real‐world applications, we have created h5bench , a set of I/O kernels that exercise hierarchical data format version 5 (HDF5) I/O on parallel file systems in numerous dimensions. Our focus on HDF5 is due to the parallel I/O library's heavy usage in various scientific applications running on supercomputing systems. The various tests benchmarked in the h5bench suite include I/O operations (read and write), data locality (arrays of basic data types and arrays of structures), array dimensionality (one‐dimensional arrays, two‐dimensional meshes, three‐dimensional cubes), I/O modes (synchronous and asynchronous). In this paper, we present the observed performance of h5bench executed along several of these dimensions on existing supercomputers (Cori and Summit) and pre‐exascale platforms (Perlmutter, Theta, and Polaris). h5bench measurements can be used to identify performance bottlenecks and their root causes and evaluate I/O optimizations. As the I/O patterns of h5bench are diverse and capture the I/O behaviors of various HPC applications, this study will be helpful to the broader supercomputing and I/O community.
Photo‐switchable Collectors for the Flotation of Lithium Aluminate for the Recycling of the Critical Raw Material Lithium
Authors: Zgheib Ali , Fischer Maximilian H. , Namyslo Jan C. , Fittschen Ursula E. A. , Wollmann Annett , Weber Alfred P. , Schmidt Andreas 
Published: April 2024

AbstractFlotation of the mineral lithium aluminate by application of the natural product punicine from Punica granatum and some derivatives as collectors is examined. Punicines, 1‐(2',5'‐dihydroxyphenyl)‐pyridinium compounds, are switchable molecules whose properties can be changed reversibly. They exist as cations, neutral mesomeric betaines, anions, and dianions depending on the pH. In light, they form radicals. Five punicine derivatives were prepared which possess β‐methyl, β‐chlorine, γ‐tert.‐butyl, and γ‐acetyl groups attached to the pyridinium ring, and a pyrogallol derivative. On the other hand, LiAlO2 reacts with water to give species such as LiAl2(OH)7 on its surface. Flotations were performed applying the punicines in daylight (3000 lux), in darkness (<40 lux) and under UV‐irradiation (4500 lux, 390–400 nm). The pH of the suspension, the collector's concentration, the conditioning time as well as the flotation time were varied. The recovery rates strongly depend on these parameters. For example, the recovery rate of lithium aluminate was increased by 116 % on changing the lighting condition from daylight to darkness, when the pyrogallol derivative of punicine was applied. UV, FTIR, TGA and zeta potential measurements as well as DFT calculations were performed in order to gain insight into the chemistry of punicines on the surface of LiAlO2 and LiAl2(OH)7 in water which influence the flotation's results.
Modification of Visible‐Light‐Responsive Pb2Ti2O5.4F1.2 with Metal Oxide Cocatalysts to Improve Photocatalytic O2 Evolution toward Z‐Scheme Overall Water Splitting
Authors: Tamura Yoshitaka , Okazaki Megumi , Ueki Hiroto , Aihara Kenta , Kanazawa Tomoki , Fan Dongxiao , Haruki Rie , Iwase Akihide , Nozawa Shunsuke , Ishiwari Fumitaka , Sugimoto Kunihisa , Saeki Akinori , Maeda Kazuhiko 
Published: April 2024

AbstractThe development of a highly active photocatalyst for visible‐light water splitting requires a high‐quality semiconductor material and a cocatalyst, which promote both the migration of photogenerated charge carriers and surface redox reactions. In this work, a cocatalyst was loaded onto an oxyfluoride photocatalyst, Pb2Ti2O5.4F1.2, to improve the water oxidation activity. Among the metal oxides examined as cocatalysts, RuO2 was found to be the most suitable, and the O2 evolution activity depended on the preparation conditions for Ru/Pb2Ti2O5.4F1.2. The highest activity was obtained with RuCl3‐impregnated Pb2Ti2O5.4F1.2 heated under a flow of H2 at 523 K. The H2‐treated Ru/Pb2Ti2O5.4F1.2 showed an O2 evolution rate an order of magnitude higher than those for the analogues without the H2 treatment (e. g., RuO2/Pb2Ti2O5.4F1.2). Physicochemical analyses by X‐ray absorption fine‐structure spectroscopy, X‐ray photoelectron spectroscopy, scanning electron microscopy, and time‐resolved microwave conductivity measurements indicated that the optimized photocatalyst contained partially reduced RuO2 species with a particle size of ~5 nm. These partially reduced species effectively trapped the photogenerated charge carriers and promoted the oxidation of water into O2. The optimized Ru/Pb2Ti2O5.4F1.2 could function as an O2‐evolving photocatalyst in Z‐scheme overall water splitting, in combination with an Ru‐loaded, Rh‐doped SrTiO3 photocatalyst.
Continuous and Scalable Synthesis of Prussian Blue Analogues with Tunable Structure and Composition in Surfactant‐Free Microreactor for Stable Zinc‐Ion Storage
Authors: Wang Mingli , Ma Jingkang , Lu Ke , Lu Songtao , Zhang Hong 
Published: April 2024

AbstractWe represent a segmented flow surfactant‐free microfluidic strategy for continuous synthesis of Prussian blue analogues (PBAs) with high dispersity and high crystallization. Representative zinc hexacyanoferrate (ZnHCF) nanocubes were successfully synthesized in a microfluidic reactor within a few minutes via the cooperation method and possessed lower contents of crystal water and Fe(CN)63− vacancies than that of synthesis in bulk solution. The nucleation and particle growth process can be precisely controlled by the exploration of different flow rates and reaction temperatures during the formation of ZnHCF nanocubes in segmented flow microfluidic reactors. High crystallinity, low crystal water and vacancies in the ZnHCF structure were presented at relatively high temperatures for the crystal growth process. High‐quality ZnHCF with a low content of crystal water showed excellent electrochemical activity and stability towards zinc‐ion storage. The continuous and scalable synthesis approach can be extended to the fabrication of other PBAs such as NiHCF, CoHCF, MnHCF, and CuHCF with high dispersity without using any surfactants. The controllable construction of PBAs with tunable properties in microfluidic reactors provides a promising direction to minimize the gap between commercial reality and laboratory research.
An integrated common ground‐based grid‐connected current‐fed switched inverter
Authors: Ravitheja Rage , Sahoo Manoranjan , Thirumala Karthik 
Published: April 2024

AbstractA current‐fed switched inverter and its derivatives are gaining more attention in solar PV grid‐connected applications. In these inverters, the absence of galvanic isolation generates the leakage current, leading to the injection of harmonics and the degradation of solar PV panel life span. This paper proposes an integrated common ground‐based grid‐connected current‐fed switched inverter. The common ground between the input DC source and output AC grid eliminates the leakage current and makes the inverter immune to high‐frequency common‐mode voltage variations. It utilizes the shoot‐through state to boost the input DC voltage and obtain the rated AC output voltage. Moreover, as compared to the contemporary common ground‐based inverter topologies, the number of passive reactive elements and active switches is less. Thereby, the size, cost of the system, and associated power loss are reduced. The proposed inverter's continuous input current and buck–boost nature make it suitable for applications like solar PV systems. The steady‐state analysis of the proposed inverter is validated using the MATLAB Simulink tool, and furthermore, the simulation results during grid‐tied mode have been cross‐verified with the help of real‐time simulator OPAL‐RT. Further, the power loss and thermal loss analysis are carried out using the PLECS software. Finally, the performance of the inverter and simulation results are verified with the experimental results.
A pilot study evaluating online training for therapist delivery of interpersonal psychotherapy for eating disorders
Authors: Karam Jones Anna M. , Fitzsimmons‐Craft Ellen E. , D'Adamo Laura , Eichen Dawn M. , Graham Andrea K. , Kolko Conlon Rachel P. , Balantekin Katherine N. , Welch R. Robinson , Agras W. Stewart , Wilson G. Terence , Wilfley Denise E. 
Published: April 2024

AbstractObjectiveIndividuals with eating disorders (EDs) often do not receive evidence‐based care, such as interpersonal psychotherapy (IPT), partly due to lack of accessible training in these treatments. The standard method of training (i.e., in‐person workshops) is expensive and time consuming, prompting a need for more scalable training tools. The primary aim of this pilot and open trial was to examine the effects of an IPT online training platform on training outcomes (i.e., IPT fidelity, knowledge, and acceptance) and, secondarily, whether online training was different from in‐person training (using a comparative sample from a separate study) in terms of training outcomes and patient symptoms.MethodParticipants were therapists (N = 60) and student patients (N = 42) at 38 college counseling centers. Therapists completed baseline questionnaires and collected data from a student patient with ED symptoms. Therapists then participated in an IPT online training program and completed post‐training assessments.ResultsFollowing online training, acceptance of evidence‐based treatments, therapist knowledge of IPT, therapist acceptance of IPT, and treatment fidelity increased; acceptance of online training was high at baseline and remained stable after training. Using the 90% confidence interval on outcome effect sizes, results suggested IPT online training was not different from in‐person training on most outcomes. Results are based on 60% of therapists who originally enrolled due to high dropout rate of therapist participants.ConclusionsFindings from this preliminary pilot study support the use of IPT online training, which could increase access to evidence‐based ED treatment and improve patient care.Public significanceLack of accessible therapist training has contributed to many therapists not delivering, and therefore many patients not receiving, evidence‐based treatment. This study evaluated a highly disseminable online training and compared outcomes to traditional in‐person training and found that training and patient outcomes were not different. Online training has the potential to enhance access to evidence‐base care, which could in turn optimize patient outcomes.
Novel Ferrocenyl‐azole Derivatives: Synthesis, DFT Calculation and Unlocking the Anticancer Potential
Authors: Tomar Vijesh , Kumar Parveen , Sharma Deepak , Singh Tejveer , Nemiwal Meena , Joshi Raj Kumar 
Published: April 2024

AbstractHerein, a series of novel ferrocenyl/phenyl/thiophenyl‐azoles was disclosed by vinylic amination of ferrocenyl/phenyl/thiophenyl substituted β‐chloro cinnamaldehydes and acrylonitriles. A highly economical and robust chalcogen‐stabilized iron selenide carbonyl cluster Fe3Se2(CO)9 worked as an efficient catalyst under aerobic conditions. The amination of ferrocenyl/phenyl/thiophenyl substituted β‐chloro‐vinylic Csp2‐Cl with azole derivatives was fully established and fabrication of the Csp2‐N bond was completely supported by various spectral analysis. Moreover, wide range of substrates with functionally different azoles were investigated for the present reaction and good to excellent transformation was recorded. Some of the selected ferrocenated azole derivatives were screened for anti‐cancer activity against the prostate cancer cells (PC‐3) and found to be highly active at low concentration of 5.77 μM with IC50 value. Furthermore, HOMO and LUMO levels and energy gap of some selected compounds were calculated by the density functional theory (DFT).
Transfer Hydrogenolysis of O‐ and N‐Benzyl Groups in Water with Tetrahydroxydiboron by Using an Amphiphilic Polymer‐Supported Nano‐Palladium Catalyst
Authors: Zhang Kaili , Okumura Shintaro , Uozumi Yasuhiro 
Published: April 2024

AbstractDebenzylation of O‐ and N‐benzyl groups was achieved under safe and mild conditions by using B2(OH)4 as an alternative to gaseous hydrogen in the presence of an amphiphilic polystyrene‐poly(ethylene glycol) resin‐supported nano‐palladium catalyst (ARP−Pd) in water. Benzyl groups of a variety of benzylic ethers, esters, carbamates, and amines, including benzyl‐protected carbohydrates and amino acids, were reductively removed in high yields. ARP−Pd was recovered by simple filtration and reused seven times without a significant loss of its catalytic activity.
Basin‐scale responses of groundwater‐resource quality to drought and recovery, San Joaquin Valley, California
Authors: Levy Zeno F. , Jurgens Bryant C. , Faulkner Kirsten E. , Harkness Jennifer S. , Fram Miranda S. 
Published: April 2024

AbstractGroundwater‐resource quality is assumed to be less responsive to drought compared to that of surface water due to relatively long transit times of recharge to drinking‐supply wells. Here, we evidence dynamic perturbations in aquifer pressure dynamics during drought and subsequent recovery periods cause dramatic shifts in groundwater quality on a basin scale. We used a novel application of time‐series clustering on annual nitrate anomalies at >450 public‐supply wells (PSWs) across California's San Joaquin Valley during 2000–22 to group sub‐populations of wells with similar water‐quality responses to drought. Additionally, we statistically evaluated the direction and magnitude of multi‐constituent water‐quality changes across the San Joaquin Valley using a broader dataset of >3000 PSWs with data during two select hydrologic stress periods representing an extreme drought (2012–16) and subsequent recovery (2016–19). Results of time‐series clustering and stress‐period change analyses corroborate a predominant regional response to pumping stress characterized by increased concentrations of anthropogenic constituents (nitrate, total dissolved solids) and decreased concentrations of geogenic constituents (arsenic, fluoride), which largely reversed during recovery. Cluster analysis also identified a secondary, less commonly occurring group of PSWs where nitrate decreased during drought, but explanatory factor analysis was not able to discern hydrogeologic drivers for these two divergent response patterns. Long‐term tracer data support the hypothesis that the predominant regional signal of nitrate increase during drought is caused by enhanced capture of modern‐aged groundwater by PSWs during periods of pumping stress, which can drive rapid changes in water quality on seasonal and multiannual timescales. Pumping‐induced migration of modern, oxic groundwater to depth during drought may affect geochemical conditions in deeper portions of regional aquifers controlling the mobility of geogenic contaminants over the long term.
Expectations and basic knowledge in ultrasound screening among pregnant women: A questionnaire survey
Authors: Agostinho David Daniela , Pires Rafaela , Fonseca Maria João , Xavier Miguel , Branco Miguel 
Published: April 2024

AbstractObjectiveThis study aimed to evaluate the disparity of the expectations and basic knowledge of prenatal ultrasound (US) screening among pregnant women and make a comparison with the current scientific knowledge and national recommendations. We hypothesize that sociodemographic factors, including age, education, and professional occupation, may be associated with different levels of knowledge.MethodsThis was a cross‐sectional study performed in 2021 of 336 women aged 18 to 46 years in a maternity facility in a tertiary hospital in Portugal. The main outcome measures were questionnaire data from questions divided into four categories (sociodemographic, expectations, knowledge, and final considerations/suggestions). The data were grouped according to the sociodemographic factors (age, educational level, and professional occupation) and analyzed and compared as a function of the social groups as well as overall tendencies.ResultsOur data confirmed a significant discrepancy between the expectations and general knowledge of pregnant women regarding prenatal US when compared with the current scientific knowledge. Importantly, we found that both depended greatly on sociodemographic factors, particularly educational level. This reiterated the importance of conducting effective dissemination actions of current scientific knowledge, focusing on the main objectives of US screening as well as the limitations of the existing technology.ConclusionThis study will help in defining strategies for future dissemination actions aiming to improve current practice and lead to a higher synchrony of expectations towards US between couples and practitioners.