bluuebunny/crossref_metadata_2025_split huggingface dataset:
Eruptive Vellus Hair Cyst
Authors: Hornstein Edmund , Wilcox Carver , Oberlies Dennis , Schott Weldon , Hayne Steven 
Published: May 2007

Eruptive vellus hair cysts (EVHC), first described by Esterly et al. in 1977, present as asymptomatic aggregations of one to four discrete papules, each measuring up to 2 mm.1 These lesions are pigmented and range in color from red‐brown to grey‐black. They are found most commonly on the chest, though they also have been reported on the forearms, thighs, popliteal fossae, forehead, and eyelids.The etiology of EVHC is unknown but may represent an abnormality of the development of vellus hair follicles. This condition does not appear to show a predilection toward either sex, and an autosomal dominant pattern of inheritance has been postulated.2 Arising spontaneously, the lesions are usually found in the young‐to‐middle‐aged patient. Though EVHC have not been responsive to oral vitamin A therapy or keratolytic agents; the cyst may resolve spontaneously in some patients. One author3 suggests this may occur via transepithelial elimination, while another author4 postulates that their resolution is due to an intracutaneous foreign body reaction.Histologic examination reveals that the cysts are found in the middermis. They are lined by several layers of squamous epithelium and contain laminated keratinous material. Vellus hair shafts may be seen within the confines of the cyst at various planes of the section. There often is a rudimentary follicle associated with the wall of the cyst. Vellus hairs, best seen under polarized light, are characteristic of this condition. Unless the integrity of the cyst wall has been violated, there is no evidence of inflammation.
Book Reviews
Authors: BEERMAN HERMAN 
Published: May 2007

METHODS IN SKIN RESEARCH. D. Skerrow and C. J. Skerrow DISEASES OF THE HAIR AND THE SCALP. L. Bartosova, V. Jorda, and Z. Stava THE PHARMACOLOGICAL BASIS OF THERAPEUTICS. Alfred Goodman Gilman, Louis S. Gordon, Theodore W. Rail, and Ferid Murad PORTRAIT OF A ZOO. Robert and Anne Warin THE AUTHOR AND HIS AUDIENCE. TWO HUNDRED YEARS OF PUBLISHING. R. Kenneth Bussy PHILADELPHIA S PUBLISHERS AND PRINTERS: AN INFORMAL HISTORY. R. Kenneth Bussy DERMATOLOGIA NELLA PRATICA CLINICA (IN ITALIAN). Antonio Tosti ENFERMEDADES DE LA BOCA: SEMIOLOGIA, PATOLO‐CIA, CLINICA Y TERAPEUTICA DE LA MUCOSA BUCAL. David A. Crinspan INTERPRETATION OF IMMUNOFLUORESCENT PATTERNS IN SKIN DISEASE. R. Valenzuela, W. F. Bergfeld, and S. Deodhar DERMATOLOGY. Samuel L. Moschella, M.D. and Harry J. Hurley, M.D. MODELS IN DERMATOLOGY: DERMATOLOGY. 374 pages. MODELS IN DERMATOLOGY: DERMATOPHARMACOLOGY AND TOXICOLOGY. 370 pages. H. I. Maibach and N. J. Lowe REGIONAL DERMATOLOGY: A SYSTEM OE DIAGNOSIS. Ervin Epstein, M.D. TRAITE DE MYCOLOGIE MEDICALE (IN FRENCH). D. Grigoriu, J. Delacretaz, and D. Borelli
Systemic Candidiasis in Heroin Abusers Cutaneous Findings
Authors: Bielsa I. , Miro J. M. , Herrero C. , Martin E. , Latorre X. , Mascaro J. M. 
Published: May 2007

ABSTRACT: Systemic candidiasis in intravenous drug abusers (IVDA) is a new syndrome caused by Candida albicans and characterized by the sequential development of skin, eye, and osteoarticular lesions, which together form a typical clinical picture. We studied 30 patients with suggestive skin lesions: papules, nodules, and pustules in hair‐bearing areas, particularly the scalp and beard area, associated with hair invasion by candiadal hyphae.Ocular and osteoarticular involvement and presence of candidemia in some of the patients suggested blood‐borne colonization of C. albicans. The infection has been related to “brown” heroin. The origin of C. albicans and the reasons for its exclusive localization in the skin and these organs are discussed The characteristic clinical picture is widely different from that of classic disseminated candidiasis in immunodeficient patients. Therapy is also discussed.
Electron Microscopic Observation on Infected Hairs of Kerion Caused by Microsporum nanum
Authors: Wenyan Zhu , Mingyu Xia , LI Huang , Shaoxi Wu , Qing Zhong , Bian Zhao 
Published: May 2007

ABSTRACTMicrosporum nanum can afflict human hair, al‐though pigs are the usual focus of infection. Although this dermatophyte was thought to invade hair as an endothrix, electron microscopic studies show it to cause ectothrix infection due to its keratinolytic activities.
Effects of Nordihydroguaiaretic Acid, Phloretin, and Phloridzin on the Activity of Adenylate Cyclase, Lipoxygenase and Hexose Transport, and Growth of Cultured Keratinocytes
Authors: Wilkinson David I. , Orenberc Elaine K. 
Published: May 2007

ABSTRACTCompounds related to the flavonoid group of natural products may have potential as antipsoriatic drugs. The dihydrochalcone phloretin, its glycoside derivative phloridzin. and the structurally related compound nordihydroguaiaretic acid (NDCA) were selected for study, Phloretin and NDGA strongly inhibited keratinocyte growth hut had no effect on isoproterenol‐stimulated adenylate cyclase; phloridzin had no effect on growth hut potentiated the response of the enzyme. None had any effect on phosphodiesterase. Neither phloretin or phoridzin inhibited lipoxygenase or, surprisingly, decreased deoxyglucose transport. Phloretin and NDCA should he considered antipsoriatic agents.
Atrophoderma (Pasini‐Pierini)
Authors: Berman Alexander , Berman Gary D. , Winkelmann Richard K. 
Published: May 2007

ABSTRACT A patient with atrophoderma (Pasini‐Pierini) was studied. Microscopic examination showed small collections of mononuclear cells around dermal blood vessels. Electron microscopic study demonstrated macrophages and lymphocytes around vessels and between fibers in the dermis; the epidermis, dermis, collagen, and elastic fibers appeared normal. Monoclonal antibody studies of the cells in the perivascular infiltrate demonstrated cells reacting with anti‐Leu‐1 (pan‐T‐cell antibody), anti‐Leu‐3a (the helper/inducer T‐cell antibody), and OKM 1 antibody‐reacting cells (macrophages). Direct, immunofluorescent studies showed IgM and C3 staining in the small blood vessels of the papillary dermis, scattered IgM cytoids at the basement membrane, and focal fibrinogen in the mid‐dermis.Mononuclear cells in the perivascular infiltrate, similar in type and percentage concentration, have been demonstrated also in patients with anetoderma, another rare atrophic cutaneous disorder. Macrophages and T lymphocytes around papillary dermal blood vessels may play a role in the pathogenesis of atrophoderma and anetoderma.
Book Reviews
Authors: BEERMAN HERMAN 
Published: May 2007

Book review in this article: COMMON PROBLEMS IN DERMATOLOGY. Kenneth E. Greer. DERMATOLOGICAL SIGNS OF INTERNAL DISEASE. J. P. Callen, J. Jorizzo, K. E. Greer, N. Penneys, W. Piette, J. J. Zone. SURGICAL ANATOMY OF THE SKIN. Stuart J. Salache, Gerald Bernstein, Mickey Senkarik. ESSAYS ON LEPROSY. Terence J. Ryan, A. Colin McDougall, Editors.
A Preliminary Study on the Link Between PUVA and Skin Cancer
Authors: Chuang Tsu‐Yi , Tse Jimson , Cripps Derek J. 
Published: May 2007

ABSTRACTOne hundred four psoriatic patients who had 8‐methoxypsoralen‐ultraviolet light A (PUVA) treatment between 1975–1987 were investigated to determine if skin cancer had ever occurred during or after the therapeutic period. Incidence data of skin cancer was applied to this group of patients to measure the expected number of patients with skin cancer. The significance of observed number versus expected of PUVA‐treated patients with skin cancer was analyzed. The authors did not observe a significant increase of patients with skin cancer.
Drug‐Induced Toxic Epidermal Necrolysis Treated with Cyclosporin
Authors: Renfro Lisa , Grant‐Kels Jane M. , Daman Lauren A. 
Published: May 2007

ABSTRACTA 35‐year‐old woman developed toxic epidermal necrolysis secondary to phenytoin. Because the life‐threatening eruption was resistant to prednisone and high‐dose methylprednisolone therapy, cyclosporine therapy was initiated. Within 24–48 hours, the eruption stabilized and the patient improved.
Clinical Evaluation of an After‐Pediculicide Nit Removal System
Authors: Defelice Janet , Rumsfield Jean , Bernstein Joel E. , Roshal Jay Y. 
Published: May 2007

ABSTRACTA significant problem in the management of pediculosis is the removal of nits from the hair after pediculicide treatment. This study describes use of a nit removal system incorporating a creme rinse containing formic acid that loosens' the bond between the nit and hair. Twenty‐four children with pediculosis capitis, age 4 to 12 years, were evaluated. Sections of hair with equivalent numbers of nits were identified as control or test sites. Combing for 5 minutes after use of the formic acid rinse removed 93.5% of nits compared with a 27.6% reduction in the control section (p < 0.0001). These results demonstrate that use of this nit removal system greatly facilitates nit removal.
Giant Cell Tumor of Tendon Sheath
Authors: Sapra Sheetal , Prokopetz Robert , Murray A. H. 
Published: May 2007

ABSTRACT:The giant cell tumor of tendon sheath (localized nodular tenosynovitis) is the second most common tumor involving the hand but is only rarely reported in the dermatologic literature. A case of giant cell tumor and a review of the clinical and pathologic records of 111 patients are discussed.
Dermal Leishmaniasis and Rifampicin
Authors: Joshi Ravi Kumar , Nambiar P. M. K. 
Published: May 2007

ABSTRACT:In an uncontrolled study, the effectiveness of rifampicin was assessed in cutaneous leishmaniasis. Twelve of 15 patients (80%) showed good response. The treatment ranged from 2 to 12 weeks. Tolerance of the drug was excellent and apart from red discolouration of the urine, no other side effects were encountered. Rifampicin appears to have a place in the management of cutaneous leishmaniasis.
Sporotrichosis in Nepal
Authors: Rajendran C. , Ramesh V. , Misra R. S. , Kandhari S. 
Published: May 2007

Abstract:The first case of sporotrichosis from Nepal is reported in a 25–year‐old man from a village about 60 km east of Kathmandu. He never travelled outside of Nepal before and had acquired the lymphocutaneous form of the disease after an accidental injury to the right foot while cutting wood. The diagnosis of the case was made by culturing Sporothrix schenckii from the lesions, proving the dimorphic character of the fungus in vitro, its pathogenicity in mice, and its serology. Oral potassium iodide therapy resulted in complete cure.
Psychiatric Aspects of the Treatment of Mild to Moderate Facial Acne
Authors: Gupta Madhulika A. , Gupta Aditya K. , Schork Nicholas J. , Ellis Charles N. , Voorhees John J. 
Published: May 2007

Abstract:The improvement of acne appears to be associated with decreased depression and anxiety and greater satisfaction with aspects of body image that are generally unrelated to the appearance of the skin, ie, body shape and weight. The latter emphasizes the profound effect of the appearance of the skin upon the patient's overall body image. Our preliminary findings underline the need for larger controlled studies of psychosomatic factors among patients with mild to moderate acne.
Superficial Migratory Thrombophlebitis and the Lupus Anticoagulant
Authors: Blum Fredric , Gilkeson Gary , Greenberg Charles , Murray John 
Published: May 2007

ABSTRACT:The lupus anticoagulant is an antiphospholipid antibody found in association with systemic lupus erythematosus and in a variety of other diseases, as well as in healthy individuals. In the laboratory, the antibody interferes with the conversion of prothrombin to thrombin and prolongs the partial thromboplastin time. In vivo, it exerts a procoagulant effect resulting in thrombosis, mainly of the larger veins and arteries. The case of a young woman who developed superficial migratory thrombophlebitis in association with a high titer lupus anticoagulant is presented. Her diagnosis was initially missed because the partial thromboplastin time was not elevated. This appears to have resulted from the use of a specific thromboplastin relatively insensitive to the presence of the antibody. Retesting with a more sensitive reagent showed a markedly prolonged partial thromboplastin time.
Penicillamine‐Induced Pemphigus Erythematosus
Authors: Willemsen Maria J. , De Coninck Arlette L. , De Raeve Linda E. , Roseeuw Diane I. 
Published: May 2007

ABSTRACT:Pemphigus erythematosus occured in a patient with rheumatoid arthritis who was treated with D‐penicilla‐mine. The skin lesions appeared 4 months after the onset of D‐penicillamine treatment and persisted 14 years after cessation of this drug. Topical betamethasone dipropionate applications resulted in complete regression of the cutaneous lesions.
Myelofibrosis Discovered After Diagnosis of Sweet's Syndrome
Authors: Su W. P. Daniel , Alecre Victor A. , White William L. 
Published: May 2007

ABSTRACT:Multiple edematous plaques and nodules suddenly developed on the face and neck of a 26–year‐old man whose physical examination was said to be normal. Because the patient's condition fulfilled the diagnostic criteria of Sweet's syndrome, a further general medical examination and hematologic evaluation were performed. Extensive myelofibrosis was revealed by bone marrow biopsy. This case supports the belief that Sweet's syndrome is a reactive phenomenon. Because myelofibrosis was discovered in this patient after Sweet's syndrome was diagnosed, the importance of having the diagnostic criteria of Sweet's syndrome is emphasized. Careful systemic evaluation is indicated, especially when cutaneous lesions are severe or hematologic values are abnormal.
Pig Handler's Itch
Authors: Chakrabarti Amalendu 
Published: May 2007

ABSTRACT:Forty‐six humans who contacted pigs infested with Sarcoptes scabiei were investigated. Thirty (65.2%) had symptoms of sarcoptes scabies, and S. scabiei mites could be recovered from 20 (66.6%) skin scrapings. Itching was the main symptom. People within the age group of 26–35 years were infested the most. Hands and legs were the most common sites of the lesions, which subsided within 2–3 weeks when the infested pigs were treated and the intimate contact with the pigs was prevented.
Once‐Daily Naftifine Cream 1% in the Treatment of Tinea Cruris and Tinea Corporis
Authors: Jordon Robert E. , Rapini Ronald P. , Rex Ira H. , Katz H. Irving , Hickman Janet G. , Bard James W. , Medansky Roland S. , Lew‐Kaya Deborah A. , Sefton John , DeGryse Ronald E. , Killey Frank P. 
Published: May 2007

ABSTRACT:Seventy patients with tinea cruris or tinea corporis were treated with naftifine cream 1% or vehicle once daily (or 4 weeks in this double‐blind, randomized study. After two weeks, the patients using naftifine had a significantly higher mycologic cure rate than the vehicle‐treated patients (79% vs. 31 %, p < 0.001), and they showed significantly better resolution of signs and symptoms. Statistically significant differences favoring naftifine over its vehicle were found throughout the treatment period and 2 weeks posttreatment.
Psychotherapy and Neurotic Excoriations
Authors: Fruensgaard Kjeld 
Published: May 2007

ABSTRACT:During the period from 1979 to 1985, 22 patients with the primary forms of neurotic excoriations (NE) accepted referral to the author. Twenty of them completed a psychotherapy program which was eclectic in form and allowed for individual weighting of its single elements. At the follow‐up, on average after 5 years, valid evidence was found of a positive effect of goal‐directed psychotherapy in NE patients.
GRANULOMA INGUINALE: THREE CASES DIAGNOSED IN TORONTO, CANADA
Authors: HACKER PETER , FISHER BENJAMIN K. , DEKOVEN JOEL , SHIER R. MICHAEL 
Published: May 2007

AbstractGranuloma inguinale (GI) is a sexually transmitted disease seldom seen in the United States and Canada. We are reporting three cases recently seen in Toronto, Ontario, two in immigrants, and one in a native born Canadian who had an intimate relationship with a foreign visitor. The basic features of the disease are discussed.
RECESSIVE DYSTROPHIC EPIDERMOLYSIS BULLOSA TREATED WITH PHENYTOIN
Authors: ABAHUSSEIN ABDULAZIZ A. , AL‐ZAYIR AHMAD A. , MOSTAFA WEDAD Z. , OKORO ANEZI N. 
Published: May 2007

AbstractThree patients with severe recessive dystrophic epidermolysis bullosa were treated with oral phenytoin and palliative and supportive measures for variable periods. Their progress was compared with that of three milder cases managed only with palliative and supportive measures. The phenytoin‐treated group showed marked decrease in blister count, increase in trauma tolerance, a rise in hemoglobin level, and considerable weight gain. The results support earlier reports that collagenase inhibitors are useful in controlling blister formation in recessive dystrophic epidermolysis bullosa.
POST‐KALA‐AZAR DERMAL LEISHMANIASIS IN THE SUDAN: PERIPHERAL NEURAL INVOLVEMENT
Authors: ELHASSAN AHMED M. , ALI MOHAMED S. , ZIJLSTRA EDWARD , ELTOUM ISAM A. , GHALIB HASHIM W. , AHMED HYDER M.A. 
Published: May 2007

AbstractFour patients developed post‐kala‐azar dermal leishmaniasis and neuritis (PKDL) 1 to 6 months following apparently successful treatment of kala‐azar. The duration of the lesion varied between 1 month and nearly 5 years. The lesions were macules, papules, or nodules affecting the face, extremities, and trunk. The diagnosis was made by demonstration of the parasite in slit smear and biopsies and by a positive direct agglutination test (DAT). Histologically, the patients were found to have neuritis affecting the cutaneous nerves in the lesion only. The nerves showed a lymphohistiocytic infiltration and occasionally parasites. There was no impairment of sensation. Response to sodium stibogluconate was good. PKDL may simulate leprosy both clinically and pathologically.
WORLDWIDE STRATEGY FOR SKIN HEALTH CARE IN A FINANCIAL STRAIT‐JACKET
Authors: RYAN TERENCE J. 
Published: May 2007

AbstractIn consideration of the year 2000, dermatologists must take up the challenge of “Health for All.” This paper draws attention to the scope of dermatology, the nature of its work force, the qualifications that are desirable, and the deficiencies and impediments that characterize dermatologic solutions worldwide. It suggests that the future of dermatology depends on achieving appropriate and essential staffing, technology, drugs, and learning materials, within available financial resources. To achieve this, dermatologists must talk more persuasively to those who govern and some centralization of resources into regional training centers may be desirable. Delegation of skin care to purpose‐trained auxiliaries, nurses, or medical assistants is essential if costs are to be contained while enlarging the work force.
CHRONIC CUTANEOUS LEISHMANIASIS: LEISHMANIA PARASITES IN BLOOD
Authors: NUWAVRI‐SALTI NUHA , MU'ATASSEM DIA , SALMAN SALAH , IZZEDINE NAZIK , GHANI KIBBI ABDEL 
Published: May 2007

AbstractTwo patients with chronic cutaneous leishmaniasis had positive blood cultures. The diagnosis was established by the clinical picture, skin biopsy, and culture for Leishmania major and tropica.
MALIGNANT ATROPHIC PAPULOSIS (DEGOS' SYNDROME)
Authors: DEMITSU TOSHIO , NAKAJIMA KAZUYUKI , OKUYAMA RYUHEI , TADAKI TAKAYOSHI 
Published: May 2007

AbstractA 29‐year‐old Japanese man with malignant atrophic papulosis had a 1‐year history of scattered, asymptomatic, whitish or skin‐colored papules, as well as erythematous papules with central atrophy showing a porcelain‐like appearance on the trunk and extremities. Histologic examination revealed lymphocyte‐mediated necrotizing vasculitis with considerable deposition of mucin in the dermis. The wedge‐shaped necrosis of the dermis was not detected. Based on a review of the literature we think that this case represents the histologic features of the early skin lesions of malignant atrophic papulosis.
ACQUIRED PERFORATING DISEASE ASSOCIATED WITH CHRONIC RENAL FAILURE
Authors: CHANG PATRICIA , FERNANDEZ VICTOR 
Published: May 2007

A 48‐vear‐old man, in a chronic hemodialysis program, had numerous skin lesions develop that consisted of follicular papules and small hyperkeratotic nodules, located on the trunk, hips, and upper and lower extremities (where the lesions were more numerous). The nodules measured 3 to 5 mm and had a dark discoloration (Figs 1 and 2). Four months previously, the patient noticed the appearance of disseminated papular and pruritic lesions. The lesions did not improve with the prescribed local nonspecific treatment.The patient had chronic renal failure during the previous 10 years, secondary to renal vein thrombosis. As a result, he has had periodic hemodialysis for 18 months. The clinical diagnosis of the skin lesion was Kyrle disease, and a skin biopsy was performed on a nodular lesion from the thigh. The histologic sections showed skin with hyperkeratosis, an invagination of the epithelium filled with keratin and amorphous material. In some sections, the invagination appeared to be a cyst, which in serial sections, showed partial rupture of the lateral wall. No evidence of hair was found inside the invagination.
IMMUNOHISTOCHEMICAL STUDY ON THE PATTERN OF 50 KD CYTOKERATIN IN PSORIASIS
Authors: FEDI ANNA MARIA , LOTTI TORELLO , MEO ANNA LAURA , RIZZO ANGELA , LEONCINI PAOLO 
Published: May 2007

AbstractThree biopsies of normal skin and 15 biopsies collected from patients with psoriasis vulgaris were analyzed for the expression of the 50 kd cytokeratin using direct immunofluorescence and ABC technique before and after local treatment with anthralin 0.1% in a petroiatum base, with 0.05% betamethasone dipropionate cream, and finally, after PUVA treatment. Antiserum against the 50 kd anticytokeratin reacted with tissue sections of normal skin, staining cells in the basal layer, while the psoriatic skin sections before the various treatments showed a staining concerning the whole thickness of the epidermis. After the various therapies, the 50 kd cytokeratin immunoreactivity was observed only in the basal layer of those psoriatic skin sections that showed complete clinical clearing, while it was observed in the whole thickness of psoriatic patches that did not clear. These data suggest that the normalization of the 50 kd cytokeratin expression pattern can be considered as a marker of clinical remission of psoriasis.
DIFFERENTIATION OF BULLOUS PEMPHIGOID FROM EPIDERMOLYSIS BULLOSA ACQUISITA ON FROZEN SKIN BIOPSIES
Authors: VALESKI J. EDWARD , KUMAR VIJAY , BEUTNER ERNST H. , CARTONE CARMELA , KASPRZYK KATHERINE 
Published: May 2007

AbstractPatients with bullous pemphigoid and epidermolysis bullosa acquisita may have similar clinical, histologic, and routine immunohistologic features. These two diseases can be distinguished by routine diagnostic studies either on a patient's serum tested by indirect immunofluorescence on salt‐split normal skin or by obtaining a fresh perilesional skin biopsy, inducing a split at the lamina lucida, and testing for the site of IgG deposition by direct immunofluorescence. Often the serum studies are negative, while direct immunofluorescent studies yield the characteristic linear IgG staining of the basement membrane zone. To eliminate the need for a repeat biopsy to make a laboratory differential diagnosis, we studied the efficacy of salt‐splitting perilesional skin biopsies that had been previously submitted and frozen for routine direct immunofluorescent studies. The biopsies were thawed, salt‐split, and processed for direct immunofluorescence. Three epidermolysis bullosa acquisita biopsies and seven bullous pemphigoid biopsies examined demonstrated IgG staining at sites consistent with their respective diagnoses. The IgG appeared in the dermal side of the split biopsies in epidermolysis bullosa acquisita and predominantly, or exclusively, in the epidermal side in bullous pemphigoid. Thus the direct immunofluorescent study of previously frozen and subsequently salt‐split skin biopsies may be used for the differential diagnosis of bullous pemphigoid from epidermolysis bullosa acquisita. In most cases, it may eliminate the need for a repeat biopsy.