bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kualitas hidup ODHA di Klinik VCT RSUD Raden Mattaher Jambi
Authors: Ersa Chytra Bertdiana , Fitria Najmiatul , Almasdy Dedy 
Published: March 2024

Implementasi terapi Antiretroviral (ARV) dikatakan berhasil apabila kualitas hidup Orang dengan HIV/AIDS (ODHA) menjadi lebih baik (Wu, 2000). Tujuan penelitian ini adalah untuk memberikan gambaran tentang kualitas hidup ODHA di Klinik VCT RSUD Raden Mattaher Jambi berdasarkan lama penggunaan terapi ARV dan rejimen yang digunakan. Penelitian ini dilakukan secara prospektif mulai Januari hingga April 2023 di klinik VCT RSUD Raden Mattaher Jambi. Kami mengumpulkan data dari pasien klinik VCT RSUD Raden Mattaher Jambi yang memenuhi kriteria inkllusi dan eksklusi sebagai responden. Kuesioner terstruktur, instrument EQ-5D-5L dan EQ-VAS digunakan sebagai instrumen pengumpulan data. Data dianalisis menggunakan Uji Mann Whitney, Kruskall Wallis, Korelasi Spearman. Dari 349 populasi ODHA usia dewasa (≥ 18 tahun) yang terdata di klinik VCT RSUD Raden Mattaher Jambi, 152 (43,55%) diantaranya bersedia menjadi Responden penelitian dan sejumlah 143 (94%) dari total sampel yang dapat dianalisis. Hasil penelitian ini menunjukkan secara sosiodemografi tidak terdapat perbedaan bermakna nilai kualitas hidup pada variabel usia, jenis kelamin, domisili, pekerjaan, pendidikan dan status pernikahan (p<0,05) akan tetapi terdapat perbedaan bermakna nilai kualitas hidup pada faktor resiko penularan dan ada tidaknya penyakit lain (p<0,05). Ditemukan perbedaan bermakna nilai kualitas hidup pada lama penggunaan terapi ARV dimana kelompok responden yang menggunakan terapi ARV ≤ 2 tahun memiliki perbedaan bermakna dibandingkan dengan responden yang telah menggunakan terapi ARV >2 tahun (p<0,05). Tidak terdapat perbedaan bermakna pada kelompok yang menggunakan terapi ARV >2 – 5 tahun, >5 – 10 tahun maupun > 10 tahun (p>0,05). Tidak ada perbedaan nilai kualitas hidup secara bermakna pada 8 kelompok rejimen terapi ARV (p>0,05). Analisis korelasi menunjukkan terdapat hubungan positif antara nilai UEQ-5D dan UEQ-VAS dengan dengan tingkat cukup (koefisien korelasi 0,348).
Direct Admission Program Implementation: A Qualitative Analysis of Variation Across Health Systems
Authors: Taylor Jordan A. , McDaniel Corrie E. , Stevens Cathryn A. , Jacob-Files Elizabeth , Acquilano Stephanie C. , Freyleue Seneca D. , Bode Ryan , Erdem Guliz , Felman Kristyn , Lauden Stephanie , Bruce Martha L. , Leyenaar JoAnna K. 
Published: March 2024

OBJECTIVES
Direct admission (DA) to the hospital has the potential to improve family satisfaction and timeliness of care by bypassing the emergency department. Using the RE-AIM implementation framework, we sought to characterize variation across health systems in the reach, effectiveness, adoption, and implementation of a DA program from the perspectives of parents and multidisciplinary clinicians.

METHODS
As part of a stepped-wedge cluster randomized trial to compare the effectiveness of DA to admission through the emergency department, we evaluated DA rates across 69 clinics and 3 health systems and conducted semi-structured interviews with parents and clinicians. We used thematic analysis to identify themes related to the reach, effectiveness, adoption, and implementation of the DA program and applied axial coding to characterize thematic differences across sites.

RESULTS
Of 2599 hospitalizations, 171 (6.6%) occurred via DA, with DA rates varying 10-fold across health systems from 0.9% to 9.3%. Through the analysis of 137 interviews, including 84 with clinicians and 53 with parents, we identified similarities across health systems in themes related to perceived program effectiveness and patient and family engagement. Thematic differences across sites in the domains of program implementation and clinician adoption included variation in transfer center efficiency, trust between referring and accepting clinicians, and the culture of change within the health system.

CONCLUSIONS
The DA program was adopted variably, highlighting unique challenges and opportunities for implementation in different hospital systems. These findings can inform future quality improvement efforts to improve transitions to the hospital.
Curcumin mitigates ochratoxin A-induced oxidative stress and alters gene expression in broiler chicken liver and kidney
Authors: Kövesi Benjámin , Worlanyo Adanu Paul , Kulcsár Szabina , Ancsin Zsolt , Erdélyi Márta , Zándoki Erika , Mézes Miklós , Balogh Krisztián 
Published: March 2024

AbstractThe study aimed to evaluate the effect of curcumin (CURC) supplementation on broiler chickens exposed to ochratoxin A (OTA), by examining biochemical parameters and the expression of glutathione redox system genes and their regulation. OTA reduced glutathione content in the liver while increasing glutathione peroxidase activity. CURC showed no significant effects. Kidney parameters remained mostly unaffected. Gene expression analysis revealed OTA-induced upregulation of KEAP1, NRF2, AHR, GPx4 and GSR genes in the liver. CURC supplementation led to the upregulation of GPx4 and AHR genes with OTA+CURC treatment, resulting in the downregulation of GPx4, KEAP1, NRF2 and AHR genes compared to OTA treatment alone. In the kidney, GPx4 was downregulated, and NRF2 and AHR were upregulated as an effect of OTA, while CURC upregulated the NRF2 gene only. OTA+CURC treatment led to the downregulation of GPx4, GSS and AHR genes compared to the control and downregulation of NRF2 and AHR genes compared to OTA. The results suggested that CURC is partly effective against OTA-induced oxidative stress and that the effect of OTA and CURC on the antioxidant response is regulated through the KEAP1-NRF2-ARE and AHR pathways.
Crafting scenes
Authors: Healey Brett 
Published: March 2024

Effective narrative writers create immersive reader experiences through precise linguistic choices. Teachers can support effective linguistic choice-making in young writers through the process of imaginative embodiment, a method of narrative thinking framed by cognitive stylistics concepts and their embodied effects. In this article, I assess the effects of an imaginative embodiment pedagogy on fifth grade writers’ narratives by examining how their linguistic choices contribute to immersion. As part of the study, four Grade 5 teachers attended a training session on imaginative embodiment and applied the approach throughout a nine-week narrative writing unit with 12 students via one-on-one writing conferences. To study the effects of the approach, a linguistic analysis was conducted on student writing completed before and after the writing unit. The analysis was driven by a stylistic checklist that codes grammatical features to embodied effects, as well as an interpretive analysis of these features’ overall effectiveness on immersion. Findings suggested that students’ linguistic choices changed in response to learning the process of imaginative embodiment. Specifically, choices were characterized by their embodied effects, contributing to greater textual immersion. This suggests that teaching imaginative embodiment can improve writers’ narratives by affording them specific strategies for expressing meaning.
Implementasi Program Desa Berwawasan Pendidikan di Desa Betoyokauman Kecamatan Manyar Kabupaten Gresik
Authors: Abdurrahman Marzuki  
Published: March 2024

Tulisan ini mencoba mengambarkan tentang implementasi program desa berwawasan pendidikan di Desa Betorokauman Kecamaatan Manyar Kabupaten Gresik. Penelitian ini menggunakan metode kualitatif deskriptif. Dengan tahap-tahap Prapenelitian, Pekerjaan lapangan dan mengumpulkan data. kemudian validitas data dengan menggunakan trianggulasi dengan 3 cara yaitu membandingkan data hasil penelitian dengan hasil wawancara, membandingkan apa yang dikatakan dengan apa yang ada di lapangan dan membandingkan pendapat masing-masing informan seperti kepala desa, Tim pelaksana program dan masyarakat Desa Betoyokauman. Setelah itu peneliti menganalisis data dengan cara menggunakan teorinya Dedy mulyadi tentang 6 tahapan implementasi yaitu 1.) pengesahan program, 2.) Pelaksanaan Program oleh Instansi Pelaksana 3.) Kesediaan Kelompok sasaran 4.) Dampak nyata keputusan 5.) Dampak yang diharapkan oleh instansi 6.) Upaya perbaikan atas kebijakan atau peraturan perundangan. Adapun hasil penelitian tentang Program Desa Berwawasan Pendidikan sebagai berikut : Pertama Implementasi Program desa berwawasan pendidikan sudah terlaksana dengan baik sesuai dengan 6 tahapan implementasi . Kedua Dampak dari Program Desa Berwawasan Pendidikan dinilai baik oleh masyarakat Desa betoyokauman. Peneliti menemukan lebih banyak dampak positif daripada dampak negatif.
Penggunaan Media Sosial dalam Kampanye Pilpres 2024 untuk Memperebutkan Suara Generasi Muda
Authors: Noer Zulfa Jauhariyah  , Muhammad Lazuardi Ilham  , Zahratunisa  , Nurlaili Rahmawati  
Published: March 2024

Pemilihan Presiden selalu menarik perhatian masyarakat, terutama Pilpres tahun 2024. Pemilu Tahun 2024 merupakan pemilu yang istimewa karena dilakukan serentak dan hampir 60% Daftar Pemilih Tetap adalah generasi muda yang dekat dengan media sosial. Penelitian ini merupakan penelitian normatif dengan menggunakan pendekatan sosial. Hasil dari penelitian ini adalah Penggunaan media sosial oleh masyarakat bisa memberikan perubahan terhadap kondisi sosial politik di Indonesia, selain itu juga bisa mempengaruhi partisipasi para pemilih. Semakin banyaknya kampanye yang dilakukan di Media sosial, bisa menjadi suatu daya tarik bagi para pemilih. Oleh sebab itu, para kontestan pilpres 2024 harus memanfaatkan media sosial yang ada dengan membuat konten yang menarik untuk memperebutkan suara generasi muda dan memenangkan Pilpres 2024.
Focal motor seizure with automatisms in a newborn
Authors: Vecchi Marilena , Suppiej Agnese , Mastrangelo Massimo , Boniver Clementina 
Published: March 2024

ABSTRACT
Continuous synchronized video‐EEG‐polygraphic recordings allow us to better define the electroclinical patterns of epileptic events and to study the semiological features of neonatal seizures. Recently, complex behaviours and motor automatisms in newborns have been reported as being epileptic in nature. However, the debate on physiopathology (cortical or brainstem release phenomena) is ongoing. We present the synchronized video‐EEG documentation of epileptic complex motor behaviours in a newborn male. Our case contributes to the discussion regarding the semiological classification of the neonatal seizures.

[Published with video sequences]
Complex partial status epilepticus is an unrecognised feature in SESA syndrome: new insights into its pathophysiology
Authors: Fernández‐Torre José L. , Hernández‐Hernández José L. , Jiménez‐Bonilla Julio , González‐Mandly Andrés , García‐Regata Oscar 
Published: March 2024

ABSTRACT
We report a patient diagnosed as having subacute encephalopathy with frequent seizures in alcoholics (SESA syndrome), in which recurrent, non‐convulsive seizures of frontal origin contributed significantly to the alteration of the mental state. Our case suggests that the occurrence of episodes of complex partial status epilepticus (CPSE) may contribute greatly to the origin and pathophysiology of the confusional state in this rare, epileptic entity.
A case of congenital bilateral perisylvian syndrome due to bilateral schizencephaly
Authors: Vinayan K. Puthenveettil , Terada Kiyohito 
Published: March 2024

ABSTRACT
A case of congenital bilateral perisylvian syndrome (CBPS) associated with bilateral perisylvian schizencephaly in a 24‐year‐old woman is reported. She presented the classical clinical triad of CBPS, which included congenital facio‐masticatory diplegia, epilepsy and only mild mental retardation, despite the presence of bilateral, open‐lip clefts in the perisylvian region. We hypothesize that the minimal loss of cortical tissue, along with the possible sparing of vital white matter association fibers and neuronal plasticity might have contributed to the better functional outcome in this patient.
Charles Bonnet syndrome in hemianopia, following antero‐mesial temporal lobectomy for drug‐resistant epilepsy
Authors: Contardi Sara , Rubboli Guido , Giulioni Marco , Michelucci Roberto , Pizza Fabio , Gardella Elena , Pinardi Federica , Bartolomei Ilaria , Tassinari Carlo Alberto 
Published: March 2024

ABSTRACT
Charles Bonnet syndrome (CBS) is a disorder characterized by the occurrence of complex visual hallucinations in patients with acquired impairment of vision and without psychiatric disorders. In spite of the high incidence of visual field defects following antero‐mesial temporal lobectomy for refractory temporal lobe epilepsy, reports of CBS in patients who underwent this surgical procedure are surprisingly rare. We describe a patient operated on for drug‐resistant epilepsy. As a result of left antero‐mesial temporal resection, she presented right homonymous hemianopia. A few days after surgery, she started complaining of visual hallucinations, such as static or moving “Lilliputian” human figures, or countryside scenes, restricted to the hemianopic field. The patient was fully aware of their fictitious nature. These disturbances disappeared progressively over a few weeks. The incidence of CBS associated with visual field defects following epilepsy surgery might be underestimated. Patients with post‐surgical CBS should be reassured that it is not an epileptic phenomenon, and that it has a benign, self‐limiting, course which does not usually require treatment.
Ipsilateral blinking seizures during left fronto‐temporal ictal pattern on scalp EEG
Authors: Pestana Elia M. , Gupta Ajay 
Published: March 2024

ABSTRACT
We report an infant with left eye blinking seizures accompanying a left (ipsilateral) fronto‐temporal scalp EEG ictal pattern. The epileptogenic lesion was a left frontal encephalomalacia along the ventriculo‐peritoneal shunt tract. The shunt was inserted for treatment of communicating hydrocephalus. This case illustrates the lateralizing value of the ictal blinking. Review of the literature suggests that seizures with unilateral blinking are likely to be produced by activation of ipsilateral trigeminal fibers innervating subdural intracranial structures and pial vessels in temporal and frontal lobes. Ipsilateral blinking could also be produced by activation of the ipsilateral cerebellar hemisphere.
Granular cell dispersion and bilamination: two distinct histopathological patterns in epileptic hippocampi?
Authors: Silva Alexandre V. , Houzel Jean‐Christophe , Croaro Ingrid , Yacubian Elza Márcia Targas , Stavale João Norberto , Centeno Ricardo Silva , Cavalheiro Esper Abrão 
Published: March 2024

ABSTRACT

Cytoarchitectural modifications of the dentate gyrus are among the most obvious abnormalities observed in the hippocampal sclerosis associated with refractory epilepsy. Here, we examined the morphological changes of granular cells (dispersion, bilamination and cell loss) in sclerotic hippocampi from nine TLE patients, comparing abnormal and preserved areas. A total of 2 577 granular cells were analyzed with respect to four different histopathological patterns: areas with bilamination (n = 936), areas with dispersion (n = 905), areas with neuronal loss (n = 279), and preserved areas (n = 457). Quantitative parameters included somatic perimeter
(P)
, area
(A)
and form factor
(ff)
.Although different patterns were often observed in the same patient, highly significant differences were observed (p < 0.0001) when patterns were compared to one another. Since granular cell dispersion and bilamination have different morphological aspects in sclerotic hippocampi from TLE patients, we suggest that these patterns should be considered separately. Future studies are needed to determine the frequency with which these patterns occur in the general population and whether each one can interfere with seizure susceptibility.
Epilepsia partialis continua: semiology and differential diagnoses
Authors: Bien Christian G. , Elger Christian E. 
Published: March 2024

ABSTRACT

Epilepsia partialis continua (EPC) is a rare form of focal status epilepticus. It may have vascular, immune‐mediated, neoplastic or metabolic‐toxic causes. The origin of EPC has been linked with the motor cortex. This has been solidly supported by sophisticated electrophysiological studies. Here, a series of video sequences from patients with EPC (due to Rasmussen encephalitis, early‐stage multiple sclerosis, and steroid responsive encephalopathy with autoimmune thyroiditis), and other cases with repetitive myoclonic jerks or movement disorders (myoclonic epilepsy associated with ragged‐red fibers, Jacksonian march, myoclonic seizures in other types of frontal lobe or idio‐pathic generalized epilepsies, and different types of tremor) is presented.
[Published with video sequences].
Ictal asystole in temporal lobe epilepsy before and after pacemaker implantation
Authors: Strzelczyk Adam , Bauer Sebastian , Knake Susanne , Oertel Wolfgang H. , Hamer Hajo M. , Rosenow Felix 
Published: March 2024

ABSTRACTEvents of ictal bradycardia or asystole may be of relevance in epilepsy patients presenting with ictal falls, and are a potential contributor to SUDEP. The literature on ictal bradycardia or asystole is anecdotal and consists of case reports and small case series. There are no guidelines for the care of patients with ictal arrythmias. Insertion of cardiac pacemakers may prevent life‐threatening cardiac arrest, syncope and trauma.We report the case of a 41‐year‐old man who presented with refractory partial seizures resulting in syncope leading to severe head trauma, as the only ictal semiology. During presurgical video‐EEG monitoring, two episodes of ictal bradycardia followed by asystole and syncope were recorded. A cardiac pacemaker was implanted. At the nine‐month follow‐up, the patient reported no overt seizures, syncopes or traumatic falls. Our case demonstrates that implantation of a cardiac pacemaker while continuing AEDs may render a patient free from ictal symptoms and prevent ictal syncope and subsequent trauma.[Published with video sequences].
Periodic eye opening and swallowing movements associated with post‐anoxic burst‐suppression EEG pattern
Authors: Fernández‐Torre José L. , Calleja Jesús , Infante Jon 
Published: March 2024

ABSTRACT

We report a video‐electroencephalogram study of a 50‐year‐old woman who developed a clinical picture consisting of stereotyped periodic eye opening followed by eye closing, with or without swallowing movements, after a prolonged cardiopulmonary arrest. These movements were associated with a burst‐suppression pattern on the electroencephalogram.
[Published with video sequences]
Poor presurgical performance on both verbal and visual memory measures is associated with low risk for memory decline following left temporal lobectomy for intractable epilepsy
Authors: Busch Robyn M. , Chapin Jessica S. , Umashankar Gopalan , Diehl Beate , Harvey Daniel , Naugle Richard I. , Nair Dileep , Najm Imad M. 
Published: March 2024

ABSTRACT
Studies have shown a lower risk for verbal memory decline following dominant anterior temporal lobectomy (ATL) among patients with poor, presurgical verbal memory scores. It is unclear however, if the risk of decline is increased in patients who also have reduced visual memory. Objective and subjective memory outcome following left ATL was examined in twelve patients with reduced presurgical visual and verbal memory scores. Only one patient demonstrated a meaningful decline in memory scores, with a decline in visual memory following surgery. Presurgically, this patient demonstrated poor memory bilaterally on Wada testing and small discrepancy in hippocampal volumes. She was also one of two patients who continued to have seizures post‐surgery. This preliminary study suggests that patients with unilateral, left TLE and poor verbal and visual memory are unlikely to show meaningful memory declines following left ATL, particularly if they demonstrate expected patterns on Wada testing, hippocampal volume discrepancy (left < right), and postsurgical seizure‐freedom.
Cough syncope misinterpreted as epileptic seizure
Authors: Gelisse Philippe , Genton Pierre 
Published: March 2024

ABSTRACT

Cough syncopes are rare but may be one of the cause of sudden loss of consciousness. We recorded under video‐EEG monitoring a typical syncope triggered by voluntary coughing (video) and Valsava maneuvre in a patient referred for the diagnosis of generalized tonic‐clonic seizures. There were no signs of active epilepsy. The attacks were associated with overweight, obstructive sleep apnea and heavy consumption of cigarettes.
[Published with video sequences]
Absence status epilepticus in monozygotic twins with Jeavons syndrome
Authors: Yang Tianhua , Liu Yonghong , Liu Ling , Yan Bo , Zhang Qin , Zhou Dong 
Published: March 2024

ABSTRACT
As a generalized form of nonconvulsive status epilepticus (NCSE), absence status epilepticus is the most common form. It manifests as prolonged, confusional states of varying severity, and continuous or repetitive generalized discharges of spikes, multiple spikes, and slow waves on EEG. Jeavons syndrome (JS) is a new type of epilepsy syndrome. Hitherto, only four sets of monozygotic twin with JS have been reported. Absence status epilepticus occurring in monozygotic twins with JS have not been reported. Here we report on monozygotic male twins of Chinese origin with JS. Both of them presented with status epilepticus with eyelid myoclonia and absences.

[Published with video sequences]
Anatomo‐electro‐clinical correlations: the University of Cleveland, USA Case Report Case 03‐2008: Medically intractable seizures originating from the primary somatosensory hand area
Authors: Koubeissi Mohamad Z. , Maciunas Robert J. , Tanner Adriana , Lüders Hans O. 
Published: March 2024

ABSTRACT

[Case records of
Epileptic Disorders.
Anatomo‐electro‐clinical correlations. Case 03‐2008]

A 33‐year‐old woman had begun having intractable somatosensory seizures affecting the left hand since the age of 13 years. Occasionally, her seizures progressed to left arm posturing followed by secondary generalization. Scalp EEG revealed interictal epileptiform discharges in the right posterior quadrant, but with no ictal EEG correlates. Brain MRI showed a right temporal encephalomalacia, sparing mesial temporal structures, suggestive of a perinatal vascular insult. Ictal electrocorticogram, electrical stimulation mapping, and somatosensory evoked potentials localized the ictal onset to the hand area of the postcentral gyrus. Resection of that area resulted in total resolution of seizures with no significant lasting deficits. Potential complications of resecting the primary somatosensory hand area can be severe, as proprioceptive sensory loss may be permanent, resulting in significant disability. Such deficits may be temporary however, and the literature continues to report conflicting results regarding postsurgical outcome. Cortical plasticity may explain recovery of sensory deficits after partial resection of the primary somatosensory hand area. Multiple subpial transections of that area are sometimes performed to minimize functional deficits, but seizure control may be less optimal than with cortical resection.