bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relação da depressão pós parto com o aleitamento materno exclusivo: Uma análise atualizada dos aspectos clínicos e fisiopatológicos
Authors: Almeida Lais de , Alves Maria Clara Borges , Reis Julia dos 
Published: April 2024

Objetivo: O presente estudo teve como objetivo avaliar os aspectos clínicos, epidemiológicos e fisiopatológicos da associação entre a DPP e o aleitamento materno. Materiais e Métodos: O estudo será uma revisão sistemática da literatura, que utilizará as principais bases de dados: Scielo, Lilacs, Pubmed e MedLine. Serão utilizados artigos dos últimos dez anos (2013-2023) e serão utilizados os descritores Depressão Pós-Parto, Aleitamento Materno Predominante, Aleitamento Materno, Período Pós-Parto e Transtorno Depressivo. Tal revisão será organizada e listada no software Microsoft Word®, com posterior organização dos resultados. Resultados e Discussão: Estas pesquisas revelaram que mulheres que possuíam depressão pós parto, apresentaram impacto negativo no que diz respeito ao aleitamento materno e elucidaram que a falta de condições psicológicas no puerpério provocam sentimentos de estresse, medo e tristeza.Conclusão: A associação entre a depressão pós parto e o não adesão ao aleitamento materno já é bem estabelecida na literatura, sendo a queda abrupta dos hormônios gravídicos mais a suscetibilidade biológica fatores suscetíveis para o desequilíbrio no eixo HPA. Para abordar essa temática, são necessárias estratégias e políticas públicas para promover a prevenção e detecção precoce deste transtorno.
Rapid eradication of vancomycin and methicillin-resistant Staphylococcus aureus by MDP1 antimicrobial peptide coated on photocrosslinkable chitosan hydrogel: in vitro antibacterial and in silico molecular docking studies
Authors: Ekhtiari-Sadegh Sarvenaz , Samani Saeed , Barneh Farnoosh , Dashtbin Shirin , Shokrgozar Mohammad Ali , Pooshang Bagheri Kamran 
Published: April 2024

IntroductionAntibiotic resistance and weak bioavailability of antibiotics in the skin due to systemic administration leads to failure in eradication of vancomycin- and methicillin-resistant Staphylococcus aureus (VRSA and MRSA)-associated wound infections and subsequent septicemia and even death. Accordingly, this study aimed at designing a photocrosslinkable methacrylated chitosan (MECs) hydrogel coated by melittin-derived peptide 1 (MDP1) that integrated the antibacterial activity with the promising skin regenerative capacity of the hydrogel to eradicate bacteria by burst release strategy.MethodsThe MECs was coated with MDP1 (MECs-MDP1), characterized, and the hydrogel-peptide interaction was evaluated by molecular docking. Antibacterial activities of MECs-MDP1 were evaluated against VRSA and MRSA bacteria and compared to MECs-vancomycin (MECs-vanco). Antibiofilm activity of MECs-MDP1 was studied by our novel ‘in situ biofilm inhibition zone (IBIZ)’ assay, and SEM. Biocompatibility with human dermal fibroblast cells (HDFs) was also evaluated.Results and DiscussionMolecular docking showed hydrogen bonds as the most interactions between MDP1 and MECs at a reasonable affinity. MECs-MDP1 eradicated the bacteria rapidly by burst release strategy whereas MECs-vanco failed to eradicate them at the same time intervals. Antibiofilm activity of MECs-MDP1 were also proved successfully. As a novel report, molecular docking analysis has demonstrated that MDP1 covers the structure of MECs and also binds to lysozyme with a reasonable affinity, which may explain the inhibition of lysozyme. MECs-MDP1 was also biocompatible with human dermal fibroblast skin cells, which indicates its safe future application. The antibacterial properties of a photocrosslinkable methacrylated chitosan-based hydrogel coated with MDP1 antimicrobial peptide were successfully proved against the most challenging antibiotic-resistant bacteria causing nosocomial wound infections; VRSA and MRSA. Molecular docking analysis revealed that MDP1 interacts with MECs mainly through hydrogen bonds with reasonable binding affinity. MECs-MDP1 hydrogels eradicated the planktonic state of bacteria by burst release of MDP1 in just a few hours whereas MECs-vanco failed to eradicate them. inhibition zone assay showed the anti-biofilm activity of the MECs-MDP1 hydrogel too. These findings emphasize that MECs-MDP1 hydrogel would be suggested as a biocompatible wound-dressing candidate with considerable and rapid antibacterial activities to prevent/eradicate VRSA/MRSA bacterial wound infections.
Delay model for the dynamics of information units in the digital environment
Authors: Pinto Sebastián , Pardo Pintos Alejandro , Balenzuela Pablo , Trevisan Marcos A. 
Published: April 2024

The digital revolution has transformed the exchange of information between people, blurring the traditional roles of sources and recipients as active and passive entities. To study this, we build on a publicly available database of quotes, organized as units of information flowing through media and blogs with minimal distortion. Building on this, we offer an innovative interpretation of the observed temporal patterns through a minimal model with two ingredients: a two-way feedback between sources and recipients, and a delay in the media’s response to activity on blogs. Our model successfully fits the variety of observed patterns, revealing different attention decays in media and blogs, with rebounds of information typically occurring between 1 and 4 days after the initial dissemination. More important perhaps, the model uncovers a functional relationship between the rate of information flow from media to blogs and the decay of public attention, suggesting a simplification in the mechanisms of information exchange in digital media. Although further research is required to generalize these findings fully, our results demonstrate that even a bare-bones model can capture essential mechanisms of information dynamics in the digital environment.
High adherence to intermittent and continuous use of a contraceptive vaginal ring among women in a randomized controlled trial in Kigali, Rwanda
Authors: Kestelyn Evelyne , Van Nuil Jennifer Ilo , Umulisa Marie Michelle , Umutoni Grace , Uwingabire Alice , De Baetselier Irith , Uwineza Mireille , Agaba Stephen , Crucitti Tania , Delvaux Thérèse , van de Wijgert Janneke H. H. M. 
Published: April 2024

BackgroundThe introduction of female-initiated drug-delivery methods, including vaginal rings, have proven to be a promising avenue to address sexually transmitted infections and unintended pregnancies, which disproportionally affects women and girls in sub-Saharan Africa. Efficient uptake of existing and new technologies such as vaginal rings requires in depth understanding of product adherence. This remains a major challenge as data on adherence to vaginal rings from African countries is limited. In this study, we explored adherence of contraceptive vaginal ring (NuvaRing®) use in Kigali, Rwanda using a mixed methods approach.MethodsWe collected quantitative and qualitative data at multiple time points from women participating in a clinical trial exploring the safety and acceptability of either intermittent or continuous use of the NuvaRing®. Various adherence categories were used including monthly and cumulative adherence measurement. The quantitative data were analysed using R and the qualitative data were analysed using a deductive, content-analytical approach based on categories related to the quantitative adherence measures. All data were compared and triangulated.ResultsData from 120 enrolled participants showed that self-reported adherence was high at every study visit in both study groups. At first study visit 80% of the intermittent ring users and 79.7% of the continuous ring users reported perfect adherence (assessed as “the ring was never out”). Reporting of ring expulsions and removals were highest (28.3%) at the beginning of the trial. Self-reported perfect ring adherence increased during the study and reports of ring expulsions and removals declined as familiarity with this contraceptive method increased. The percentage of women with perfect cumulative adherence was non-significantly higher in the intermittent (61.7%) than in the continuous use group (54.3%). The low rate of discrepant adherence data after triangulation (6%) is in line with the perception of the participants as adherent throughout the study.ConclusionsSelf-reported adherence in both study groups was high with removals and expulsions being within the expected product range. Comprehensive adherence data triangulation allowed for a deeper understanding of context-driven behaviour that shaped adherence patterns and challenges. Our data categorisation and triangulation approach has shown potential for implementation in future vaginal ring studies aiming to better understand and measure adherence.
The predictive value of next generation sequencing for matching advanced hepatocellular carcinoma patients to targeted and immunotherapy
Authors: Du Jiajia , Zhang Erlei , Huang Zhiyong 
Published: April 2024

BackgroundTargeted and Immunotherapy has emerged as a new first-line treatment for advanced hepatocellular carcinoma (aHCC). To identify the appropriate targeted and immunotherapy, we implemented next generation sequencing (NGS) to provide predictive and prognostic values for aHCC patients.MethodsPretreatment samples from 127 HCC patients were examined for genomic changes using 680-gene NGS, and PD-L1 expression was detected by immunohistochemistry. Demographic and treatment data were included for analyses of links among treatment outcomes, drug responses, and genetic profiles. A prognostic index model for predicting benefit from treatment was constructed, taking into account of biomarkers, including TP53, TERT, PD-L1, and tumor mutation burden (TMB) as possible independent prognostic factors.ResultsThe multivariate Cox regression analyses showed that PD-L1≥1% (HR 25.07, 95%CI 1.56 - 403.29, p=0.023), TMB≥5Mb (HR 86.67, 95% CI 4.00 - 1876.48, p=0.004), TERT MU (HR 84.09, 95% CI 5.23 - 1352.70, p=0.002) and TP53 WT (HR 0.01, 95%CI 0.00 - 0.47, p=0.022) were independent risk factors for overall survival (OS), even after adjusting for various confounders. A prognostic nomogram for OS was developed, with an area under the ROC curve of 0.91, 0.85, and 0.98 at 1-, 2-, and 3- year, respectively, and a prognostic index cutoff of 1.2. According to the cutoff value, the patients were divided into the high-risk group (n=29) and low-risk group (n=98). The benefit of targeted and immunotherapy in the low-risk group was not distinguishable according to types of agents. However, treatment of Atezolizumab and Bevacizumab appeared to provide longer OS in the high-risk group (12 months vs 9.2, 9, or 5 months for other treatments, p&lt;0.001).ConclusionThe prognostic model constructed by PD-L1, TMB, TERT, and TP53 can identify aHCC patients who would benefit from targeted and immunotherapy, providing insights for the personalized treatment of HCC.
The predictive value of T-cell chimerism for disease relapse after allogeneic hematopoietic stem cell transplantation
Authors: Li Zhipeng , Wang Jing , Deng Lei , Liu Ximin , Kong Fanjun , Zhao Yuerong , Hou Yixi , Zhou Fang 
Published: April 2024

IntroductionChimerism is closely correlated with disease relapse after allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, chimerism rate is dynamic changes, and the sensitivity of different chimerism requires further research.MethodsTo investigate the predictive value of distinct chimerism for relapse, we measured bone marrow (BM), peripheral blood (PB), and T-cell (isolated from BM) chimerism in 178 patients after allo-HSCT.ResultsReceiver operating characteristic (ROC) curve showed that T-cell chimerism was more suitable to predict relapse after allo-HSCT compared with PB and BM chimerism. The cutoff value of T-cell chimerism for predicting relapse was 99.45%. Leukemia and myelodysplastic syndrome (MDS) relapse patients’ T-cell chimerism was a gradual decline from 2 months to 9 months after allo-HSCT. Higher risk of relapse and death within 1 year after allo-HSCT. The T-cell chimerism rates in remission and relapse patients were 99.43% and 94.28% at 3 months after allo-HSCT (P = 0.009), 99.31% and 95.27% at 6 months after allo-HSCT (P = 0.013), and 99.26% and 91.32% at 9 months after allo-HSCT (P = 0.024), respectively. There was a significant difference (P = 0.036) for T-cell chimerism between early relapse (relapse within 9 months after allo-HSCT) and late relapse (relapse after 9 months after allo-HSCT) at 2 months after allo-HSCT. Every 1% increase in T-cell chimerism, the hazard ratio for disease relapse was 0.967 (95% CI: 0.948–0.987, P&lt;0.001).DiscussionWe recommend constant monitoring T-cell chimerism at 2, 3, 6, and 9 months after allo-HSCT to predict relapse.
A practical guide to the management of immune thrombocytopenia co-existing with acute coronary syndrome
Authors: Rahhal Alaa , Provan Drew , Ghanima Waleed , González-López Tomás José , Shunnar Khaled , Najim Mostafa , Ahmed Ashraf Omer , Rozi Waail , Arabi Abdulrahman , Yassin Mohamed 
Published: April 2024

IntroductionImmune thrombocytopenia (ITP) management with co-existing acute coronary syndrome (ACS) remains challenging as it requires a clinically relevant balance between the risk and outcomes of thrombosis and the risk of bleeding. However, the literature evaluating the treatment approaches in this high-risk population is scarce.Methods and ResultsIn this review, we aimed to summarize the available literature on the safety of ITP first- and second-line therapies to provide a practical guide on the management of ITP co-existing with ACS. We recommend holding antithrombotic therapy, including antiplatelet agents and anticoagulation, in severe thrombocytopenia with a platelet count &lt; 30 × 109/L and using a single antiplatelet agent when the platelet count falls between 30 and 50 × 109/L. We provide a stepwise approach according to platelet count and response to initial therapy, starting with corticosteroids, with or without intravenous immunoglobulin (IVIG) with a dose limit of 35 g, followed by thrombopoietin receptor agonists (TPO-RAs) to a target platelet count of 200 × 109/L and then rituximab.ConclusionOur review may serve as a practical guide for clinicians in the management of ITP co-existing with ACS.
Accuracy of toric intraocular lens power calculation depending on different keratometry values using a novel network based software platform
Authors: Ramsauer Michaela , Luft Nikolaus , Vounotrypidis Efstathios , Priglinger Siegfried G. , Mayer Wolfgang J. 
Published: April 2024

PurposeTo compare different corneal keratometry readings (swept-source-OCT-assisted biometry and Scheimpflug imaging) with a novel software platform for calculation of toric intraocular lenses.SettingDepartment of Ophthalmology, Ludwig-Maximilians-University, Munich, Germany.DesignRetrospective, non-randomized, clinical trial.MethodsTwenty-three eyes undergoing toric intraocular lens implantation were included. Inclusion criteria were preoperative regular corneal astigmatism of at least 1.00 D, no previous refractive surgery, no ocular surface diseases and no maculopathies. Lens exchange was performed with CALLISTO eye (Zeiss). For each patient, the expected postoperative residual refraction was calculated depending on three different corneal parameters of two different devices: standard K-front (K) and total keratometry (TK) obtained by a swept-source-OCT-assisted biometry system (IOL Master 700, Zeiss) as well as total corneal refractive power (TCRP) obtained by a Scheimpflug device (Pentacam AXL, Oculus). Barrett’s formula for toric intraocular lenses was used for all calculations within a novel software platform (EQ workplace, Zeiss FORUM®). Results were statistically compared with postoperative refraction calculated according to the Harris dioptric power matrix.ResultsThe standard K values (mean PE 0.02 D ± 0.45 D) and TK values (mean PE 0.09 D ± 0.43 D) of the IOL Master 700 reached similar results (p = 0.96). 78% of eyes in both K and TK groups achieved SE within ±0.5 D of attempted correction and all eyes (100%) were within ±1.0 D of attempted correction in both groups. By contrast, the prediction error in the IOL calculation using the TCRP of the Scheimpflug device was significantly greater (mean PE −0.56 D ± 0.49 D; p = 0.00 vs. standard K and p = 0.00 vs. TK) with adjusted refractive indices. Thirty-nine and Ninety-one percentage of eyes in the TCRP group achieved SE within ±0.5 D (p = 0.008 K vs. TCRP and p = 0.005 TK vs. TCRP) and ± 1.0 D (p = 0.14 vs. TCRP) of attempted correction, respectively.ConclusionAll three corneal parameters (standard K, TK, TCRP) performed well in calculating toric IOLs. The most accurate refractive outcomes in toric IOL implantation were achieved by IOL calculations based on swept-source-OCT-assisted biometry. The SS-OCT-based K-front and TK values achieve comparable results in the calculation of toric IOLs.
Real-world evidence on tagraxofusp for blastic plasmacytoid dendritic cell neoplasm – collected cases from a single center and case reports
Authors: Faustmann Philipp , Schroeder Jan C. , Mix Lucas , Harland Lennart , Riedel Andreas , Vogel Wichard , Lengerke Claudia , Wirths Stefan 
Published: April 2024

IntroductionBlastic plasmacytoid dendritic cell neoplasia (BPDCN) is a rare, aggressive hematologic malignancy. Until recently, the only curative treatment consisted of intensive chemotherapy, followed by hematopoietic cell transplantation (HCT) in eligible adult cases. Tagraxofusp, a CD123-targeted protein-drug conjugate and the first approved targeted treatment for BPDCN, might enhance outcomes especially in patients not eligible for intensive therapies.MethodsHere, we report real-world outcomes of five male patients with a median age of 79 years who received tagraxofusp as first-line treatment for BPDCN.ResultsTagraxofusp was found to be well-tolerated in this elderly cohort, with only one patient requiring discontinuation. Three patients responded to the treatment (two patients achieved a CR and one patient achieved a partial response), of which two subsequently underwent allogeneic (allo) HCT. One patient is alive and well after ≥ 4 years after alloHCT, and one patient shows sustained CR after now 13 cycles of tagraxofusp. The other three patients died of progressive disease 4-11 months after initiation of treatment.DiscussionIn line with results from 13 published cases outside clinical trials in the literature, sustained responses were associated with CR after tagraxofusp treatment and subsequent alloHCT. Our results provide real-world evidence for safety and efficacy of tagraxofusp as first-line treatment for BPDCN.
The Simplified Medication Adherence Questionnaire: validation of a Brazilian-Portuguese version in hypertensive adults
Authors: Soares Simony M. , Diniz Mirela Q. de Almeida , Davino Dilcy Morgana B. M. C. , Albieri Fernanda B. , Santos Adriano S. , Jesus Elisdete M. S. , Lyra-Junior Divaldo P. , Neves Sabrina J. , Oliveira-Filho Alfredo D. 
Published: April 2024

Background:Self-reported adherence scales are widely used in research and practice because they are low in cost and easy to apply. A free version in Brazilian-Portuguese of the Simplified Medication Adherence Questionnaire (SMAQ) can be a useful alternative for determining the adherent behavior of hypertensive patients.Purpose:To translate and evaluate the psychometric properties of the Brazilian-Portuguese version of the SMAQ therapeutic adherence scale for patients with arterial hypertension.Patients and methods:A multicenter, cross-sectional study was conducted in five outpatient units in Maceió-AL and Aracaju-SE between January and July 2019. A total of 117 patients aged over 18 years using antihypertensive drugs were recruited. The cross-cultural adaptation followed international methodological recommendations. Internal consistency (Cronbach’s alpha) was tested as a reliability parameter. Criterion and construct validity were verified by concurrent validation, exploratory factor analysis (EFA), and validation by known groups.Results:The participants had a mean age of 56.6 years (SD = 10.7 years); most were female (72.6%). The mean number of antihypertensives prescribed per patient was 1.87 (SD = 0.87). There were 79.5% (n = 86) of patients considered non-adherent. Internal consistency was satisfactory (Cronbach’s alpha = 0.63). A satisfactory correlation coefficient was verified with the Morisky–Green–Levine test as an external criterion (r = 0.56, p &lt; 0.001). The scale’s sensitivity measured through known group validity was 75.3%, specificity 29.5%, positive predictive value 63.9%, and negative predictive value 41.9%. We identified two factors of the instrument’s construct from EFA: specific medication-taking behaviors and barriers to adherence. The initial KMO measure of sampling adequacy was 0.691, and Bartlett’s test of sphericity was significant (χ2 = 118.342, p &lt; 0.001).Conclusion:The Brazilian-Portuguese version of the SMAQ scale proved valid and reliable for determining adherence to the pharmacotherapy in hypertensive patients. It showed more ability to detect non-adherent patients but with low specificity, possibly influenced by high social desirability.
Terawatt-class femtosecond long-wave infrared laser
Authors: Pogorelsky Igor. V. , Polyanskiy Mikhail N. , Babzien Marcus , Simmonds Andrew , Palmer Mark A. 
Published: April 2024

We utilized a nonlinear post-compression technique to generate 675-fs, 9.2-μm CO2 laser pulses with a peak power of 1.6 TW. This achievement represents the highest peak power ever attained in the femtosecond pulse format within the long-wave infrared (LWIR) spectral range. The successful implementation of this post-compression technique opens avenues for the development of few-cycle, multi-terawatt 9–10 μm lasers, crucial for applications currently relying on near-infrared solid-state lasers, and which stand to benefit from the scaling of laser wavelengths into the long-wave infrared region.
The association between uncertainty intolerance, perceived environmental uncertainty, and ego depletion in early adulthood: the mediating role of negative coping styles
Authors: Li Xiao , Song Jingjing 
Published: April 2024

IntroductionUncertainty intolerance and perceived environmental uncertainty can influence an individual’s emotions and behavioral responses. Previous research showed that high uncertainty intolerance and high perceived environmental uncertainty were both negatively associated with an individual’s life satisfaction. We explored the interaction effects of uncertainty intolerance and perceived environmental uncertainty on ego depletion of early adulthood and its mechanisms.MethodsInvestigating 292 college students using an uncertainty intolerance scale, a perceived environmental uncertainty scale, a negative coping style questionnaire, and an ego depletion scale. The correlations among all variables were calculated using Pearson’s product-moment correlation coefficient, and then we used the PROCESS macro (model 8) in SPSS to test the conditional process model in the relationship between uncertainty intolerance and ego depletion.ResultsThe results showed that the interaction terms of uncertainty intolerance and perceived environmental uncertainty were significantly associated with negative coping styles. Only in the high perceived environmental uncertainty situations, uncertainty intolerance was positively associated with negative coping styles, and negative coping styles were positively associated with ego depletion.DiscussionIn general, compared with perceived environmental uncertainty, participants’ cognition towards environmental uncertainty was much more associated with individual’s coping styles and psychological state, individuals with high uncertainty intolerance would face great stress and experience more emotional problems. Our results suggest that it is important for individuals’ mental health to gain a sense of control in an uncertain environment and improve the tolerance of uncertainty. Future research needs to pay attention to the intervention strategy of decreasing uncertainty intolerance.