bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between polymorphisms in cell cycle genes and advanced prostate carcinoma
Authors: Kibel Adam S. , Jin Carol H. , Klim Aleksandra , Luly Jason , A. Roehl Kimberly , Wu William S. , Suarez Brian K. 
Published: May 2008

AbstractBackgroundSingle nucleotide polymorphisms (SNPs) have been associated with a variety of malignancies including prostate carcinoma (PCa). Since a high percentage of PCa patients have low risk disease, of particular interest is not whether SNPs are associated with localized PCa, but whether they are associated with aggressive, potentially lethal disease. Herein, we explored the role of SNPs in cell cycle genes to determine if they were associated with advanced PCa.MethodsNine previously implicated SNPs in six cell cycle genes were evaluated in a European‐American cohort of 186 patients with advanced PCa and 222 cancer‐free controls. All patients received hormone ablation and had either a PSA >50 ng/ml or documented metastatic disease. Controls were all 75 years of age or older, had a negative DRE and had a PSA <4.0 ng/ml. All genotypes were determined using Pyrosequencing™ assays.ResultsOne of nine (CDKN1A c10791t) was statistically different (P < 0.05) and an additional two of nine (CCND1 a870g and MDM2 tSNP309g) approached significance (P < 0.1). Analysis of genotypes revealed that presence of at least one copy of the t allele of MDM2 tSNP309g was associated with an increased risk of advanced PCa (OR 2.26: 95% CI = 1.15–4.46) which was particularly strong in androgen‐independent disease (OR 2.28: 95% CI = 1.01–5.12) and younger age of diagnosis (OR 2.61: 95% CI = 1.05–6.46).ConclusionThese results suggest that in a European‐American population, SNPs within cell cycle genes are promising markers for aggressive PCa. Larger studies will be needed to confirm these findings. Prostate 68: 1179–1186, 2008. © 2008 Wiley‐Liss, Inc.
Expression of microRNAs and protein‐coding genes associated with perineural invasion in prostate cancer
Authors: Prueitt Robyn L. , Yi Ming , Hudson Robert S. , Wallace Tiffany A. , Howe Tiffany M. , Yfantis Harris G. , Lee Dong. H. , Stephens Robert M. , Liu Chang‐Gong , Calin George A. , Croce Carlo M. , Ambs Stefan 
Published: May 2008

AbstractBackgroundPerineural invasion (PNI) is the dominant pathway for local invasion in prostate cancer. To date, only few studies have investigated the molecular differences between prostate tumors with PNI and those without it.MethodsTo evaluate the involvement of both microRNAs and protein‐coding genes in PNI, we determined their genome‐wide expression with a custom microRNA microarray and Affymetrix GeneChips in 50 prostate adenocarcinomas with PNI and 7 without it. In situ hybridization (ISH) and immunohistochemistry was used to validate candidate genes.ResultsUnsupervised classification of the 57 adenocarcinomas revealed two clusters of tumors with distinct global microRNA expression. One cluster contained all non‐PNI tumors and a subgroup of PNI tumors. Significance analysis of microarray data yielded a list of microRNAs associated with PNI. At a false discovery rate (FDR) <10%, 19 microRNAs were higher expressed in PNI tumors than in non‐PNI tumors. The most differently expressed microRNA was miR‐224. ISH showed that this microRNA is expressed by perineural cancer cells. The analysis of protein‐coding genes identified 34 transcripts that were differently expressed by PNI status (FDR < 10%). These transcripts were down‐regulated in PNI tumors. Many of those encoded metallothioneins and proteins with mitochondrial localization and involvement in cell metabolism. Consistent with the microarray data, perineural cancer cells tended to have lower metallothionein expression by immunohistochemistry than nonperineural cancer cells.ConclusionsAlthough preliminary, our findings suggest that alterations in microRNA expression, mitochondrial function, and cell metabolism occur at the transition from a noninvasive prostate tumor to a tumor with PNI. Prostate 68: 1152–1164, 2008. Published 2008 Wiley‐Liss, Inc.
Excitons in motion: universal dependence of the magnetic moment on kinetic energy
Authors: Kochereshko V. P. , Smith L. C. , Davies J. J. , Cox R. T. , Platonov A. , Wolverson D. , Boukari H. , Mariette H. , Cibert J. , Wiater M. , Wojtowicz T. , Karczewski G. 
Published: May 2008

AbstractWe have observed remarkable changes in the magnetic properties of excitons as they acquire kinetic energy. In particular, the Zeeman splittings and diamagnetic shifts of excitonic transitions when magnetic fields are applied along the growth direction of (001) wide quantum wells of CdTe, ZnSe, ZnTe and GaAs are found to to have a strong dependence on the translational wavevector Kz. The behaviour of the Zee‐man splittings corresponds to enhancement of the magnetic moments of the excitons. This enhancement is particularly marked when their translational kinetic energy becomes comparable with the exciton Rydberg and can be described by what appears to be a universal function of Kz. A model for the behaviour is outlined which involves motionally‐induced mixing between the 1S hydrogenic exciton ground state and excited nP states. The observations imply that there are significant changes in the structure of the exciton as its translational kinetic energy increases. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Rare Earth Metal‐Rich Magnesium Compounds RE4IrMg (RE = Y, La, Pr, Nd, Sm, Gd, Tb, Dy) and RE23Ir7Mg4 (RE = La, Ce, Pr, Nd)
Authors: Rodewald Ute Ch. , Tuncel Selcan , Chevalier Bernard , Pöttgen Rainer 
Published: May 2008

AbstractThe rare earth metal–rich compounds RE4IrMg (RE = Y, La, Pr, Nd, Sm, Gd, Tb, Dy) and RE23Ir7Mg4 (RE = La, Ce, Pr, Nd) were synthesized from the elements in sealed tantalum tubes in an induction furnace. Several structures were investigated on the basis of X‐ray single crystal diffraction: P63mc, Z = 2, a = 1001.2(7), c = 2257.2(5) pm, wR2 = 0.0441, 2402 F2 values, 74 variables for Pr23Ir6.81Mg4, Gd4RhIn type, $F{\bar 4}{\rm 3}m$, Z = 16, a = 1438.3(2) pm, wR2 = 0.0490, 542 F2 values, for La4IrMg, a = 1405.6(2) pm, wR2 = 0.0368, 451 F2 values, for Nd4IrMg, a = 1381.2(2) pm, wR2 = 0.0541, 480 F2 values, for Gd4IrMg, a = 1370.7(2) pm, wR2 = 0.0377, 392 F2 values, for Tb4IrMg with 19 variables per refinement. All other compounds have been characterized by X‐ray powder diffraction data. Pr23Ir6.81Mg4 crystallizes with a new structure type. The three crystallographically independent iridium atoms have trigonal prismatic praseodymium coordination with short Ir–Pr distances ranging from 285 to 300 pm. The trigonal prisms are condensed to a three‐dimensional network via common edges and corners. Voids in the network are filled by the coordination polyhedra of the Pr4 and Pr6 atoms and Mg4 tetrahedra (312‐317 pm Mg–Mg). Similar structural motifs occur in the compounds RE4IrMg, however, with a different connectivity of the building groups. The crystal chemistry of both structure types is comparatively discussed.
Synthesis and Spectroscopic Characterization of Azolium Picrate Salts
Authors: Klapötke Thomas M. , Sabaté Carles Miró 
Published: May 2008

AbstractTetrazoles are valuable intermediates for the synthesis of energetic materials and combined with energetic anions such as azide, dinitramide, nitrate or picrate give compounds with interesting energetic properties. Azolium picrate salts with the following cations were prepared in high yields and purities: 1‐methyl‐5‐amino‐1H‐tetrazolium (1a), 1,4‐dimethyl‐5‐amino‐1H‐tetrazolium (2a), 1‐methylguanazinium (3a) and 1,3‐dimethyl‐5‐amino‐1H‐tetrazolium (4a). The compounds were fully characterized by elemental analysis, mass spectrometry and vibrational and multinuclear NMR (1H, 13C and 15N) spectroscopies. The thermal behavior of the picrate salts was assessed by DSC (Differential Scanning Calorimetry) measurements revealing high thermal stabilities. In addition, the long‐term stabilities of compounds 1a and 4a was assessed by TSC (Thermal Safety Calorimetry). Lastly, all compounds described here are stable to water and can easily be prepared on a large scale from cheap starting materials, making them of interest as new energetic compounds.
1‐D Supramolecular Arrangement of [{C6H5NNN(O)C6H5}V(O)2(C5H5N)] and [{O2NC6H4NNN(O)C6H5}V(O)2(C5H5N)] through Hydrogen Bonding – Stabilization of cis‐Dioxovanadium(V)(Pyridyne) Fragments with 1,3‐Disubstituted Triazenido 1‐Oxide Anions as Ligands
Authors: Hörner Manfredo , Iglesias Bernardo Almeida , Martins Paulo Roberto , Mendes Villis Paulo Cesar , do Canto Visentin Lorenzo 
Published: May 2008

AbstractThe reaction of 1,3‐bis(phenyl)triazene 1‐oxide with VOSO4·5H2O in the presence of potassium ethanolate in ethanol yields yellow vitreous crystals of [{C6H5NNN(O)C6H5}V(O)2(C5H5N)] (1) and [{O2NC6H4NNN(O)C6H5}V(O)2(C5H5N)] (2) after recrystallization from acetone/pyridine. 1 and 2 complex molecules are associated to [{C6H5NNN(O)C6H5}V(O)2(C5H5N)]2 and [{O2NC6H4NNN(O)C6H5}V(O)2(C5H5N)]2 dimeric units through centrosymmetric C–H···O interactions, respectively. The centrosymmetric dimers – related to each other by translation – are connected to on‐dimensional chains along to the crystallographic direction [010] in the case of 1, and along to the crystallographic direction [100] in the case of 2, generating a supramolecular 1‐D arrangement, respectively. The single‐crystal X‐ray structural analysis of 1 and 2 are the first reported in the literature bearing a triazenido 1‐oxide anion stabilizing a cis‐dioxovanadium(V) fragment.
Supramolecular Structure Formed by Directed Intermolecular Interactions in a Lead(II) Complex
Authors: Marandi Farzin , Fun Hoong‐Kun 
Published: May 2008

AbstractTo investigate the interactions between noncovalent bond donor and acceptor giving rise to three dimensional networks, compound [Pb(tfpb)2]n (Htfpb = 4,4,4‐trifluoro‐1‐phenyl‐1,3‐butanedione) has been prepared and characterized by elemental analysis, IR, 1H NMR, and 13C NMR spectroscopy and its crystal structure was investigated. The single‐crystal structure of the compound show the coordination number of Pb(II) to be eight with six O‐donor atoms from a “tfpb” ligand and two F‐donors from the anionic ligands. The supramolecular structure of 1 is realized by weak directional C–F···F–C and π–π stacking interactions.
Synthetic, Structural and Magnetic Studies on Chromium Orthoborate
Authors: Öztürk Ömer F. , Zümreoglu‐Karan Birgül , Can Musa M. 
Published: May 2008

AbstractEffects of various Cr and B sources and preheating conditions on the high temperature synthesis of chromium orthoborate were studied. Precursors were mixed, ground, heated at 1000 °C and reground. The obtained products were checked by XRD, vibrational and electronic spectroscopy, SEM and density measurements. Some characteristic properties were redetermined and compared with the earlier data. The reaction between hydrated Cr(III) sulfate and boric acid (or hydrated ammonium borate salts) was found to be the most effective in providing nanosize crystallites of calcite‐type CrBO3 with 99 % purity. Finally, temperature dependent magnetic properties were investigated and paramagnetic to antiferromagnetic transition was observed at 12 K.
Synthesis and Characterization of [(C2H8NO)2Zn5(HPO3)6(H2O)2]·(H2O)2: a New 2D Hybrid Zinc Phosphite with Neutral Framework
Authors: Wang Guo‐Ming , Li Jin‐Hua , Li Zeng‐Xin , Xue Shu‐Yun , Li Hui 
Published: May 2008

AbstractA new layered inorganic‐organic hybrid zinc phosphite, [(HEA)2Zn5(HPO3)6(H2O)2]·(H2O)2 (EA = ethanolamine), has been hydrothermally synthesized and structurally characterized by single crystal X‐ray diffraction, FTIR, elemental analysis, powder X‐ray diffraction and thermogravimetric analysis. The compound crystallizes in the triclinic system, space group $P{\bar 1}$ (No. 2), a = 8.6068(2) Å, b = 10.1061(2) Å, c = 10.2804(4) Å, α = 117.680(3)°, β = 95.917(2)°, γ = 101.716(2)°, V = 755.00(2) Å3, and Z = 1. The structure consists of ZnO4 tetrahedra, ZnO4(OH)2 octahedra and HPO3 pseudopyramids which are linked together through their vertexes forming neutral sheet‐like architecture. The adjacent layers are stably packed together and exhibit interesting 3‐D supramolecular framework through multipoint hydrogen bonds between the neutral framework and the extra‐framework water molecules.
The Fluorinated Lithiumalkoxide LiORF (RF = C(CF3)2Mes), the Alcohol RFOH and Attempts to use them as Precursors for New Weakly Coordinating Anions (WCAs)
Authors: Müller Lutz O. , Scopelitti Rosario , Krossing Ingo 
Published: May 2008

AbstractThe Li alkoxides [LiORF]4 (1), [LiORF]4[LiF]2 (2) and the solvent coordinated Li‐gallate Li(C2H4Cl2)[Ga(ORF)2(Br)2] (RF = C(CF3)2Mes) (3) were prepared by reacting a stoichiometric amount of Mes‐Li·OEt2 and gaseous (CF3)2CO giving 1. Subsequently, 2 was formed in 28 % yield in a poorly understood sequence by addition of AlBr3 to 1. Upon addition of GaBr3 to four equivalents of 1 compound 3 formed. The Li alkoxide 1 forms a puckered eight membered (Li–O)4 ring and compound 2 forms an almost ideal double heterocubane with a complexed Li2F2 four membered ring in the center. The Li‐gallate 3 contains the tetrahedral anion [Br2Ga(ORF)2]− and coordinates a Li(Cl2C2H4)+ cation by two contacts to the oxygen atoms of the alkoxide. The latter describes the first account of a Li‐chloroalkane complex. 1 to 3 were characterized by multinuclear NMR, IR and Raman spectroscopy as well as by their single‐crystal X‐ray structures. It appears that the steric bulk of the ORF alkoxide is too large to allow for the desired synthesis of the weakly coordinating anions [M(ORF)4]− (M = Al, Ga). In agreement with this, the also prepared new fluorinated alcohol HO–RF did neither react with LiAlH4 (various solvents) nor could electrochemically be reduced with H2 formation (CV).
Synthesis, Structural Characterization and Luminescent Properties of a Mixed Valence Hexavanadate Cluster
Authors: Zhang Gui‐Ling , Li Yan‐Tuan , Luo Xu‐Qiang , Wu Zhi‐Yong 
Published: May 2008

AbstractAn inorganic‐organic vanadate compound [V6O12(OCH3)4(dmbpy)4·2H2O] (dmbpy = 4,4′‐dimethyl‐2,2′‐bipyridine) has been synthesized and characterized by elemental analyses, IR, UV spectra and single crystal X‐ray diffraction. The compound crystallizes in monoclinic system, space group P21/n (No. 14), a = 11.317(2) Å, b = 18.557(3) Å, c = 14.630(3) Å, β = 101.58(4)°, V = 3012.5(9) Å3, and Z = 2. The crystal structure consists of a new hexavanadate cluster and four dmbpy groups which directly coordinated to vanadium through nitrogen atoms. The hydrogen bonds contribute to the formation of the three‐dimensional supramolecular structure. Fluorescent analyses show that it exhibits intense blue photoluminescence in DMF solution at room temperature.
A New Anderson‐type Heteropolyanion‐Supported Transition Metal Complex: [Himi]2[Ni(imi)3(H2O){Ni(OH)6Mo6O18}]·2H2O
Authors: Li Jing , Zhang Lan‐Cui , Sun Zhen‐Gang , Tian Cui‐Hua , Zhu Zai‐Ming , Zhao Yan , Zhu Yan‐Yu , Zhang Jing , Zhang Na , Liu Lei , Lu Xin 
Published: May 2008

AbstractA new Anderson‐type heteropolyanion‐supported nickel imidazole complex, [Himi]2[Ni(imi)3(H2O){Ni(OH)6Mo6O18}]·2H2O (imi = imidazole) (1) has been prepared by conventional aqueous solution synthesis and structurally characterized by single‐crystal X‐ray diffraction as well as by infrared spectroscopy, elemental and thermogravimetric analysis. Compound 1 possesses a one‐dimensional (1D) wave‐like infinite chain structure composed of Anderson‐type heteropolyanion [Ni(OH)6Mo6O18]4− covalently linked by [Ni(imi)3(H2O)]2+ unit. Furthermore, the chains are extended into a 2D supramolecular framework in the ac plane via hydrogen‐bonding interactions.
Syntheses, Structures and Reactivity of Novel Hydrates of ortho‐Sulfidostannte Salts
Authors: Ruzin Eugen , Jakobi Stephan , Dehnen Stefanie 
Published: May 2008

AbstractBy the synthesis of single‐crystalline K+, Rb+, Cs+ and Ba2+ salts of the ortho‐sulfidostannate anion, using an efficient, three‐step fusing/extraction/evaporation method, all of the “missing links” in the table of ortho‐sulfidostannates that can be prepared by this method, were added. The resulting hydrate compounds have the general composition [An(H2O)m][SnS4] and represent useful starting materials for the synthesis of transition metal complexes with [SnS4]4− groups as binary main group elemental ligands. A quaternary salt [Cs10(H2O)18][Mn4(μ4‐S)(SnS4)4] results from a reaction of the ternary Cs+ salt with MnCl2·4H2O. [K4(H2O)4][SnS4] (1), [Rb4(H2O)4][SnS4] (2), [Cs4(H2O)3][SnS4] (3), [Ba2(H2O)11][SnS4] (4), and [Cs10(H2O)18][Mn4(μ4‐S)(SnS4)4] (5) were characterized by means of X‐ray diffractometry and optical absorption spectroscopy.
C6N7H3O3·H2N(CH3)2Cl·H2O – a Dimethylammonium Chloride Adduct of Cyameluric Acid – Synthesis, Structure and Properties
Authors: Sattler Andreas , Schnick Wolfgang 
Published: May 2008

AbstractThe dimethylammonium chloride adduct hydrate of cyameluric acid was obtained by slow hydrolytic decomposition of cyameluric chloride C6N7Cl3 dissolved in N,N‐dimethylformamide. Single crystals of C6N7H3O3·H2N(CH3)2Cl·H2O have been obtained after evaporation of the solvent. The structure has been determined by single‐crystal XRD (P 21/c, a = 6.0908(12), b = 22.710(5), c = 9.821(2) Å, β = 105.63(3)°, V = 1308.2(5) Å3, Z = 4, T = 130 K). In the solid, only the all‐keto tautomere of cyameluric acid occurs. The molecular entities are interconnected by an extensive hydrogen bonding network. Vibrational and thermal properties of the compound have been investigated.
Mg[ZnPO4(H2O)]2·10H2O – a Layered Hydrous Zinc Phosphate Retrieved from an Industrial Filter Cake Residual
Authors: Kahlenberg V. , Tessadri R. , Többens D. M. , Wertl W. , Rössler A. 
Published: May 2008

AbstractA phase analysis of an industrial filter cake residual based on X‐ray powder diffraction data gave evidence for the existence of a previously unknown hydrous magnesium zinc phosphate. An optical investigation of the sample indicated the presence of milky white crystals (intergrown with polycrystalline rutile) with a maximum diameter of about 150 μm. Aided by an EDX‐analysis, a single crystal diffraction study performed at −100 °C proofed that the material represents a phase with composition Mg[ZnPO4(H2O)]2·10H2O. Basic crystallographic data are as follows: monoclinic symmetry, space group P21/c, a = 10.702(1), b = 7.4740(9) Å, c = 11.444(1) Å, β = 104.09(1)°, V = 887.8(2) Å3, Z = 2, (R(|F|) = 0.048). From a structural point of view the new compound is based on [ZnPO4(H2O)]− layers containing ZnO3(H2O)‐ and PO4‐tetrahedra arranged at the vertices of a 4.82 net. The layers are parallel to (100) and alternate with sheets of isolated Mg(H2O)62+‐octahedra and additional interstitial water molecules. Linkage between the tetrahedral and octahedral sheets is provided by hydrogen bonding. The topology and geometry of the tetrahedral layers are very similar to those observed in the minerals veszelyite, herderite and kipushite. According to the DTA‐measurements the present compound is stable up to 89 °C, where dehydration to an amorphous product occurs.
Synthesis and Characterization of the First 1‐D Borate Templated by Transition Metal Complex
Authors: Wang Guo‐Ming , Li Jin‐Hua , Li Zeng‐Xin , Wang Pei , Li Hui 
Published: May 2008

AbstractA novel decaborate compound, [Ag(py)2]2[B10O14(OH)4] (py = pyridine) (1), has been hydrothermally synthesized and structurally characterized by single crystal X‐ray diffraction, FTIR, elemental analysis, and thermogravimetric analysis. The compound crystallizes in the monoclinic system, space group P21/c (No. 14), a = 15.7115(7), b = 13.1477(6), c = 16.9463(8) Å, β = 105.2690(2)°, V = 3377.0(3) Å3, and Z = 4. The structure of the compound consists of infinite unusual wave‐like borate chains constructed from large [B10O14(OH)4]2− groups. It represents the first example of a one‐dimensional borate templated by a transition metal complex. Adjacent borate chains are further linked together by extensive hydrogen bonds to form a 3D supramolecular network with regular cyclic‐ and ellipse‐like channels, in which the transition metal templates [Ag(py)2]+ reside.
Synthesis and Crystal Structure of Silver Nesosilicate, Ag4SiO4
Authors: Klein Wilhelm , Jansen Martin 
Published: May 2008

AbstractThe new silver silicate Ag4SiO4 has been obtained by solid state reactions starting from stoichiometric amounts of the binary oxides at elevated temperatures and oxygen pressures. Ag4SiO4 crystallizes in space group P42/n (No. 86) with a = 7.3169(3), c = 4.9595(4) Å, V = 265.52(3) Å3, Z = 2; the structure refinement was based on 343 independent reflections and resulted in R1 = 2.70 %, wR2 = 5.85 %. The crystal structure consists of isolated SiO4 tetrahedra which are linked by Ag cations. The Ag atoms are almost linearly coordinated by two oxygen atoms. The AgO2 dumbbells form chains, and every two of these chains are wound around each other forming double helices running along [001]. This arrangement of Ag and O atoms corresponds to a section of the Ag2O structure. Ag4SiO4 is photosensitive and decomposes within a few weeks into silver, SiO2 and oxygen.
New Nitrosyl Bis‐o‐iminobenzosemiquinonato Complexes of M(ISQ)2(NO) Type
Authors: Poddel'sky Andrey I. , Bubnov Michail P. , Fukin Georgy K. , Cherkasov Vladimir K. , Abakumov Gleb A. 
Published: May 2008

AbstractThe tetracoordinate bis‐o‐iminobenzosemiquinonato cobalt and iron complexes, Co(ISQ‐Pri)2 (1), Co(ISQ‐Me)2 (2), Fe(ISQ‐Pri)2 (3), Fe(ISQ‐Me)2 (4), (ISQ‐Pri is 4,6‐di‐tert‐butyl‐N‐(2,6‐di‐iso‐propylphenyl)‐o‐iminobenzosemiquinone and ISQ‐Me is 4,6‐di‐tert‐butyl‐N‐(2,6‐dimethylphenyl)‐o‐iminobenzosemiquinone, respectively) react with nitrogen(II) oxide to form the pentacoordinate nitrosyl derivatives M(ISQ‐R)2(NO) 5–8 (M = Co, R = Pri (5), R = Me (6); M = Fe, R = Pri (7), R = Me (8)). NO binding is reversible. Complexes have been characterized by IR, UV‐vis spectroscopy, EPR and Mössbauer (for 7) spectroscopy. The molecular structure of cobalt nitrosyl complex 6 was determined by X‐ray diffraction analysis. The spectroscopic and X‐ray structural features of the complexes are consistent with the {Co‐NO}8 and {Fe‐NO}7 formulations. The nitrosyl ligand in cobalt complexes 5 and 6 is coordinated in a bent fashion. In the case of iron complexes 7 and 8, neutral NO· ligand is coordinated to low‐spin iron(II).
Twenty‐five years of Zoo Biology: a publication analysis
Authors: Anderson Ursula S. , Kelling Angela S. , Maple Terry L. 
Published: May 2008

AbstractTo expand on earlier publication analyses of the journal Zoo Biology, information from 991 articles published within the journal's first 25 years was compiled and evaluated. Most articles were applied, descriptive accounts that included inferential statistics and/or biological analyses. In addition, most articles focused on captive animals and concentrated on the behavior and reproduction of mammals, with particular emphasis on primates. With respect to authors, the majority of first authors were affiliated with zoos or universities within the United States and collaborated with co‐authors at different institutions. Nearly two‐fifths of articles acknowledged receiving external funding and external funding increased over the years, however, collaboration did not significantly change receipt of external funding. In addition, first authors with zoo affiliations published more descriptive, applied science articles and acknowledged receipt of external funding significantly less often than first authors with university affiliations. Publication latency was comparable to other scientific journals and increased significantly over the 25‐year publication period. Longitudinal trends indicated that experimental, applied science, diet and nutrition, and collaborative articles also increased significantly, whereas descriptive, basic science, behavior, and population biology articles decreased significantly. By describing historical trends in zoo research through an analysis of papers published in Zoo Biology, this article may help to bridge gaps and identify new opportunities. Zoo Biol 27:444–457, 2008. © 2008 Wiley‐Liss, Inc.