bluuebunny/crossref_metadata_2025_split huggingface dataset:
Norms for the mini‐mental state examination from a sample of Sri Lankan older people
Authors: De Silva Ranil , Disanayaka Sarada , De Zoysa Nayomi , Sanjeewanie Niluka , Somaratne S. , Foster Jonathan , Srikanth S. , Kathriarachchi Samudra T. , Martins Ralph M. 
Published: January 2009

AbstractObjectiveTo derive norms for the Mini Mental State Examination (MMSE) based on age, gender and level of formal education among the elderly in Sri Lanka.MethodA validated Sinhalese version of the MMSE was administered to people aged 55 years and above residing in 14 randomly selected elders' homes. Effects of age, gender and level of formal education on MMSE scores were compared using multiple linear regression analysis.ResultsA total of 446 subjects [male/female = 136/320] formed the final sample. Level of education and gender exerted a significant influence on MMSE scores, but not age. The median and 10th percentile scores on the Sinhalese MMSE for the education groups were as follows: education <5 years = 19 and 12; education >5 years = 24 and 16, respectively.ConclusionThe findings confirm the influence of level of education on MMSE scores among the elderly living in care homes in Sri Lanka, and suggest that education stratified cut‐off scores should be used while screening for cognitive impairment in this population. Copyright © 2009 John Wiley & Sons, Ltd.
Elective neck dissection for the management of the N0 neck in early cancer of the oral tongue: Need for a randomized controlled trial
Authors: D'Cruz Anil K. , Siddachari Ravichand C. , Walvekar Rohan R. , Pantvaidya Gouri H. , Chaukar Devendra A. , Deshpande Mandar S. , Pai Prathamesh S. , Chaturvedi Pankaj 
Published: January 2009

AbstractBackgroundThe aim of this study is to determine the need for a randomized controlled trial in order to define the role of an elective neck dissection (END) in the treatment of early tongue cancers.MethodsWe present a large retrospective analysis of patients with T1‐2 N0 squamous cell cancers of the oral anterior tongue treated at a single institution. A total of 359 eligible patients with early tongue cancers were divided into 2 groups: END and wait and watch (WW). An analysis for survival outcomes and prognostic factors was conducted.ResultsThe estimated 3‐ and 5‐year disease‐free survival for the END group was 76% and 74% versus 71% and 68% for the WW group, respectively (p = .53). The 3‐ and 5‐year overall survival (OS) rate for the END group was 69% and 60% versus 62% and 60% for the WW group, respectively (p = .24). Tumor grade and perineural invasion were independent predictors of recurrence.ConclusionEND did not impact disease‐free or OS. Current literature still remains divided on this issue emphasizing the need for a randomized controlled trial. © 2009 Wiley Periodicals, Inc. Head Neck 2009
Extramammary myofibroblastoma in the head and neck region
Authors: Hox Valerie , Poorten Vincent Vander , Delaere Pierre R. , Hermans Robert , Debiec‐Rychter Maria , Sciot Raf 
Published: January 2009

AbstractBackgroundMammary myofibroblastoma is a benign mesenchymal tumor of the breast. Extramammary location is very rare and usually occurs along the embryonic milk‐line.Methods and ResultsIn this article, we present a case of a woman with an infra‐auricular swelling. A diagnosis could not be made on CT scans, so the mass was surgically removed. Histological examination showed spindle cells in clusters, with CD34, desmin, and actin expression. The diagnosis of extramammary myofibroblastoma was made.ConclusionWe describe this case because of the unusual location of this rare tumor. Furthermore, we want to highlight the possible relationship between (extra)mammary myofibroblastoma and spindle cell lipoma (SCL). SCL has a predilection site in the posterior neck. Both tumors show the same clinical behavior, a close histological resemblance, and their cells are both immunoreactive for CD34 and CD10. The loss of RB/13q14 and FKHR/13q14 loci, which is typically found in SCL cells, was also shown in this case. © 2009 Wiley Periodicals, Inc. Head Neck, 2009
Radiotherapy for perineural invasion in cutaneous head and neck carcinomas: Toward a risk‐adapted treatment approach
Authors: Jackson James E. , Dickie Graeme J. , Wiltshire Kirsty L. , Keller Jacqui , Tripcony Lee , Poulsen Michael G. , Hughes Mary , Allison Roger W. , Martin Jarad M. 
Published: January 2009

AbstractBackgroundWe retrospectively reviewed outcomes in patients treated with radiotherapy (RT) for cutaneous head and neck carcinoma with perineural invasion (PNI), with the aim of developing risk‐adapted treatment guidelines.MethodsA total of 118 patients were treated with RT between April 1992 and July 2000. Ninety‐seven patients had PNI discovered through histology (pPNI) and 21 patients had symptoms/signs of PNI (cPNI). All received RT (median dose, 55 Gy; range, 17–74): 114 postoperatively and 4 definitively. Median follow‐up was 84 months (range, 4–201).ResultsThe 5‐year local control (LC) rates were 90% with pPNI and 57% with cPNI (p < .0001). The pPNI and cPNI groups also differed in relapse‐free survival (76% vs 46%, p = .003), disease‐specific survival (90% vs 76%, p = .002), and overall survival (69% vs 57%, p = .03). pPNI patients with BCC histology (n = 42) had better LC (97% vs 84%, p = .02) than pPNI SCC (n = 55).ConclusionSurgery plus RT provides a high rate of LC in patients with pPNI, particularly those with BCC. Therapeutic improvements are needed for patients with cPNI. © 2009 Wiley Periodicals, Inc. Head Neck, 2009
Evaluation of treatment results with regard to initial anterior commissure involvement in early glottic carcinoma treated by external partial surgery or transoral laser microresection
Authors: Sachse Florian , Stoll Wolfgang , Rudack Claudia 
Published: January 2009

AbstractBackgroundModalities of surgical treatment of early glottic carcinoma include transoral laser microresection and external partial surgery.MethodsThis is a retrospective analysis of 119 glottic carcinomas treated by external partial surgery (57 pT1a, 1 pT1b, 10 pT2) or transoral laser microresection (46 pT1a, 4 pT1b, 1 pT2) with special regard to initial anterior commissure involvement.ResultsLocal recurrence in external partial surgery was 12%. Three‐ and 5‐year local control was 86%. Local recurrence in transoral laser microresection was 16%. Three‐ and 5‐year local control was 88% and 70%, respectively. No significant correlation was found between local control and surgical approach. An analysis of all 119 tumor revealed that anterior commissure involvement significantly decreased local control.ConclusionInitial anterior commissure involvement was associated with a higher risk of local recurrence. Overall, treatment of glottic carcinoma involving the anterior commissure requires much experience and advanced surgical skills regardless which technique is preferred. © 2009 Wiley Periodicals, Inc. Head Neck 2009
Expression modes and clinical manifestations of latent membrane protein 1, Ki‐67, cyclin‐B1, and epidermal growth factor receptor in nonendemic nasopharyngeal carcinoma
Authors: Taheri‐Kadkhoda Zahra , Magnusson Bengt , Svensson Marie , Mercke Claes , Björk‐Eriksson Thomas 
Published: January 2009

AbstractBackgroundWe aimed to identify clinical significance of latent membrane protein 1 (LMP1), Ki‐67, cyclin‐B1, and epidermal growth factor receptor (EGFR), in nonendemic nasopharyngeal carcinoma (NPC).MethodsThe relation between expression of the markers in 45 NPC specimens and clinicopathological and survival variables was statistically analyzed.ResultsLMP1 was present in 33% of the tumors, and its presence was associated with advanced nodal and disease stages. Overexpression was defined as labeling index ≥ median value for Ki‐67, ≥ 15% for cyclin‐B1, and ≥50% for EGFR, and it was displayed in 50%, 55%, and 80% of the specimens, respectively. Strong EGFR staining intensity and not overexpression of the 3 markers was the variable with statistically significant impact on treatment outcomes in terms of worse local and locoregional tumor control rates.ConclusionsOur results suggest that the evaluation of EGFR staining intensity in patients with NPC may identify a subgroup of patients with poor prognosis. © 2009 Wiley Periodicals, Inc. Head Neck, 2009
Functional analysis of neurovascular adaptations to exercise in the dentate gyrus of young adult mice associated with cognitive gain
Authors: Clark Peter J. , Brzezinska Weronika J. , Puchalski Emily K. , Krone David A. , Rhodes Justin S. 
Published: January 2009

AbstractThe discovery that aerobic exercise increases adult hippocampal neurogenesis and can enhance cognitive performance holds promise as a model for regenerative medicine. This study adds two new pieces of information to the rapidly growing field. First, we tested whether exercise increases vascular density in the granular layer of the dentate gyrus, whole hippocampus, and striatum in C57BL/6J mice known to display procognitive effects of exercise. Second, we determined the extent to which new neurons from exercise participate in the acute neuronal response to high levels of running in B6D2F1/J (F1 hybrid of C57BL/6J female by DBA/2J male). Mice were housed with or without a running wheel for 50 days (runner vs. sedentary). The first 10 days, they received daily injections of BrdU to label dividing cells. The last 10 days, mice were tested for performance on the Morris water maze and rotarod and then euthanized to measure neurogenesis, c‐Fos induction from running and vascular density. In C57BL/6J, exercise increased neurogenesis, density of blood vessels in the dentate gyrus and striatum (but not whole hippocampus), and enhanced performance on the water maze and rotarod. In B6D2F1/J, exercise also increased hippocampal neurogenesis but not vascular density in the granular layer. Improvement on the water maze from exercise was marginal, and no gain was seen for rotarod, possibly because of a ceiling effect. Running increased the number of c‐Fos positive neurons in the granular layer by fivefold, and level of running was strongly correlated with c‐Fos within 90 min before euthanasia. In runners, ∼3.3% (±0.008 S.E.) of BrdU‐positive neurons in the middle of the granule layer displayed c‐Fos when compared with 0.8% (±0.001) of BrdU‐negative neurons. Results suggest that procognitive effects of exercise are associated with increased vascular density in the dentate gyrus and striatum in C57BL/6J mice, and that new neurons from exercise preferentially function in the neuronal response to running in B6D2F1/J. © 2009 Wiley‐Liss, Inc.
Religion and spirituality in psychotherapy: a practice‐friendly review of research
Authors: Post Brian C. , Wade Nathaniel G. 
Published: January 2009

AbstractThe role of religion and spirituality in psychotherapy has received growing attention in the last two decades, with a focus on understanding the ways that religion and spirituality relate to therapists, clients, and treatment methods. The authors reviewed recent empirical research on religion and spirituality in psychotherapy to inform practitioners about effective ways to incorporate the sacred into their clinical work. Three main areas are covered: religion/spirituality and therapists, religion/spirituality and clients, and religious/spiritual interventions. Research indicates that therapists are open to religious/spiritual issues, that clients want to discuss these matters in therapy, and that the use of religious/spiritual interventions for some clients can be an effective adjunct to traditional therapy interventions. © 2009 Wiley Periodicals, Inc. J Clin Psychol: In Session 65:131–146, 2009.
A Theistic spiritual treatment for women with eating disorders
Authors: Richards P. Scott , Smith Melissa H. , Berrett Michael E. , O'Grady Kari A. , Bartz Jeremy D. 
Published: January 2009

AbstractThe authors describe a psychological treatment for women with eating disorders who have theistic spiritual beliefs and illustrate its application with a case report. They begin by briefly summarizing a theistic view of eating disorders. Then they illustrate how a theistic approach can complement traditional treatment by describing the processes and outcomes of their work with a 23‐year‐old Christian woman receiving inpatient treatment for an eating disorder not otherwise specified and a major depressive disorder (recurrent severe). © 2009 Wiley Periodicals, Inc. J Clin Psychol: In Session 65:172–184, 2009.
Religiously oriented mindfulness‐based cognitive therapy
Authors: Hathaway William , Tan Erica 
Published: January 2009

AbstractThe interface of religiously accommodative and oriented treatments and the cognitive–behavioral tradition is explored. In terms of Hayes' characterization of the evolution of the cognitive–behavioral tradition through three waves, considerable theoretical, clinical, and empirical work emerged to support a religiously accommodative cognitive–behavioral therapy (CBT) during the second‐generation CBTs. Rather than including religion and spirituality, the third‐wave CBT traditions have engaged in spiritual themes inspired heavily from Eastern religious traditions. The authors discuss the application of a religiously congruent third‐wave cognitive therapy with a depressed conservatively Christian client. Some conceptual challenges and rationales for adopting such treatments with Christian or other theist clients are described. © 2009 Wiley Periodicals, Inc. J Clin Psychol: In Session 65:158–171, 2009.
The KK‐Periome database for transcripts of periodontal ligament development
Authors: Saito Masahiro , Nishida Eisaku , Sasaki Takashi , Yoneda Toshiyuki , Shimizu Nobuyoshi 
Published: January 2009

AbstractThe periodontal ligament (PDL) is a strong connective tissue that surrounds the tooth root, absorbs occlusal forces, and functions as a sense organ. PDL originated from dental follicle (DF), which possessed mesenchymal progenitors in the developing tooth germ. However, as specific marker genes for PDL and DF are currently unavailable, the molecular mechanisms of PDL development are yet to be clarified. To facilitate the identification of such genes, we have previously established a transcriptome database of the human PDL (the KK‐Periome database) and screened for specific genes expressed during PDL development. Initial screening of the database revealed two marker genes for distinguishing DF and PDL. The KK‐Periome database thus appears to offer a useful resource for investigating genes involved in PDL development. J. Exp. Zool. (Mol. Dev. Evol.) 312B:495–502, 2009. © 2009 Wiley‐Liss, Inc.
Spermiogenic nuclear protein transitions and chromatin condensation. Proposal for an ancestral model of nuclear spermiogenesis
Authors: Kurtz Kathryn , Saperas Núria , Ausió Juan , Chiva Manel 
Published: January 2009

AbstractWe have chosen three species (Sparus aurata, Dicentrarchus labrax, and Monodonta turbinata) that represent different transition patterns in the composition and structure of spermiogenic nuclei. The transition patterns of these species are representative of spermiogenesis in a large number of animal species. We analyze: (a) nuclear protein exchange; (b) chromatin condensation pattern; and (c) histone acetylation during spermiogenic development. In the simplest spermiogenesis histones and nucleosomes remain in mature sperm. Chromatin of spermatids is organized into 20 nm granules, simultaneous with a nuclear volume reduction. The granules coalesce in the final stage of spermiogenesis. Granular chromatin is correlated with acetylation of histones H3 and H4, whereas final coalescence is associated with histone deacetylation. We also studied two other spermiogenesis where a basic protein substitutes histones. Each species has a very different substituting protein. One has a typical protamine of 34 amino acids; the other has a sperm nuclear basic proteins (SNBP) of 106 amino acids. In both, the structural transitions and histone acetylation pattern are similar: in early spermiogenesis chromatin is organized into 20 nm granules, and histones are significantly acetylated, while the nuclear volume decreases. Subsequently, acetylated histones are displaced by the protamine or SNBP. Histone substitution causes chromatin remodelling and additional reduction in nuclear volume. We analyze these three cases together with earlier works and propose that the formation of 20 nm granules containing acetylated H3 and H4 accomplishes the minimum functional requirement to be considered the most evolutionarily ancestral chromatin conformation preceding condensation in animal spermiogenesis. J. Exp. Zool. (Mol. Dev. Evol.) 312B:149–163, 2009. © 2009 Wiley‐Liss, Inc.
Synthesis and biodistribution in mice of 99mTcN–DBODC–DMSEt
Authors: Yang Shuye , Wang Xuebin , Guo Haixun , Liu Jian , Wang Fenglong , Zhang Xianzhong 
Published: January 2009

AbstractNitrido technetium(V)‐mixed ligand complex of 99mTcN–DBODC–DMSEt [DMSEt: Monoethyl ester of (meso) 2,3‐dimercaptosuccinic acid, DBODC: bis(2‐ethoxyethyl)carbamodithioate] has been prepared in a two‐step procedure by first reaction of 99mTcO with succinic dihydrazede in the presence of stannous chloride as a reducing agent and propylenediamine tetraacetic acid as a complexant, followed by the addition of DMSEt and DBODC. The complex was stable over 6 h at room temperature. The partition coefficient indicated that it was a hydrophilic complex. Biodistribution in mice demonstrated that the complex accumulated mainly in liver, lungs and kidneys. Copyright © 2009 John Wiley & Sons, Ltd.
Transition metals as electron traps. I. Structures, energetics, electron capture, and electron‐transfer‐induced dissociations of ternary copper–peptide complexes in the gas phase
Authors: Tureček František , Jones Jace W. , Holm Anne I. S. , Panja Subhasis , Nielsen Steen Brøndsted , Hvelplund Preben 
Published: January 2009

AbstractElectron‐induced dissociations of gas‐phase ternary copper‐2,2′‐bipyridine complexes of Gly‐Gly‐Gly and Gly‐Gly‐Leu were studied on a time scale ranging from 130 ns to several milliseconds using a combination of charge‐reversal (+CR−) and electron‐capture‐induced dissociation (ECID) measured on a beam instrument and electron capture dissociation (ECD) measured in a Penning trap. Charge‐reduced intermediates were observed on the short time scale in the +CR− and ECID experiments but not in ECD. Ion dissociations following electron transfer or capture mostly occurred by competitive bpy or peptide ligand loss, whereas peptide backbone fragmentations were suppressed in the presence of the ligated metal ion. Extensive electron structure theory calculations using density functional theory and large basis sets provided optimized structures and energies for the precursor ions, charge‐reduced intermediates, and dissociation products. The Cu complexes underwent substantial structure changes upon electron capture. Cu was calculated to be pentacoordinated in the most stable singly charged complexes of the [Cu(peptide − H)bpy]+ • type where it carried a ∼+ 1 atomic charge. Cu coordination in charge‐reduced [Cu(peptide − H)bpy] intermediates depended on the spin state. The themodynamically more stable singlet states had tricoordinated Cu, whereas triplet states had a tetracoordinated Cu. Cu was tricoordinated in stable [Cu(peptide − H)bpy]− • products of electron transfer. [Cu(peptide)bpy]2 + • complexes contained the peptide ligand in a zwitterionic form while Cu was tetracoordinated. Upon electron capture, Cu was tri‐ or tetracoordinated in the [Cu(peptide)bpy]+ charge‐reduced analogs and the peptide ligands underwent prototropic isomerization to canonical forms. The role of excited singlet and triplet electronic states is assessed. Copyright © 2009 John Wiley & Sons, Ltd.
Statistical‐dynamical prediction of the Madden–Julian oscillation using NCEP Climate Forecast System (CFS)
Authors: Seo Kyong‐Hwan 
Published: January 2009

AbstractThe predictive performance of the Madden–Julian Oscillation (MJO) in the National Centers for Environmental Prediction's (NCEP's) operational coupled, Climate Forecast System (CFS) model is assessed and statistical‐dynamical hybrid models are developed based on this numerical model to improve forecasting skill. By projecting ENSO‐removed variables onto the principal patterns of the MJO convection and upper‐ and lower‐level circulations, MJO‐related signals in the dynamical model forecasts are extracted. It is found that the coupled model exhibits useful predictability out to 2 and 3 pentads when the initial MJO convection is located over the Maritime Continent and the Indian Ocean, respectively. The first hybrid model (HYBRID1) developed is a lagged multiple linear regression scheme, where the previous values of the first two leading principal components (PCs) from the coupled model are used as predictors along with the latest observed PC values. The other hybrid model (HYBRID2) is constructed to fit the predicted PC time series from the coupled model to the observed PCs at each lead time using 13 years of training data fields. HYBRID2 does not produce persistent improvement in forecast skill compared to CFS, whereas for HYBRID1, the resulting correlation coefficient and root mean square (RMS) skills are considerably enhanced due to the incorporation of lagged correlation information between the two PCs. The skill improvement of HYBRID1 ranges from 15 to 50% relative to the CFS forecast and the improvement in the correlation skill is greater than the RMS error correction. When the MJO convection is located initially over the Maritime Continent during the northern summer, the CFS forecast skill is as small as the persistence forecast, whereas HYBRID1 demonstrates the greatest skill improvement. During ENSO winters, the forecast skill is enhanced by ∼30% by HYBRID1. In particular, the skill improvement in La Niña years is noticeably greater than in El Niño years. Copyright © 2009 Royal Meteorological Society
Length change patterns of the extensor retinaculum and the effect of total knee replacement
Authors: Ghosh Kanishka M. , Merican Azhar M. , Iranpour‐Boroujeni Farhad , Deehan David J. , Amis Andrew A. 
Published: January 2009

AbstractPatellofemoral dysfunction following total knee replacement (TKR) is a significant clinical problem, but little information exists on the mechanics of the patellofemoral retinacula or the effects of TKR on these structures. We hypothesized that TKR would cause significant elongation of the retinacula. Retinacular length changes were measured by threading sutures along the retinacula, fixing the sutures to the patella and the iliotibial band (ITB), and attaching the femoral ends to displacement transducers. The intact knee was flexed‐extended while the quadriceps and ITB were tensed and the retinacular length change patterns were recorded. The measurements were repeated post‐TKR. The medial patellofemoral ligament (MPFL) was close to isometric, stretching 2 mm in terminal knee extension, whereas the lateral retinaculum slackened 8 mm from 110° to 0° flexion. TKR did not cause significant elongation of either of the retinacula, the largest change being 3 mm elongation of the MPFL around 40°, which stretched the MPFL by 1.4 mm above its maximum natural length. Thus, this work did not support the hypothesis that TKR causes significant elongation of the retinacula sufficient to affect knee function. © 2009 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 27: 865–870, 2009