bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modulation of Tropical Convection‐Circulation Interaction by Aerosol Indirect Effects in Convective Self‐Aggregation Simulations of a Gray Zone Global Model
Authors: Su Chun‐Yian , Wu Chien‐Ming , Chen Wei‐Ting , Peters John M. 
Published: March 2024

AbstractDisentangling the response of tropical convective updrafts to enhanced aerosol concentrations has been challenging. Leading theories for explaining the influence of aerosol concentrations on tropical convection are based on the dynamical response of convection to changes in cloud microphysics, neglecting possible changes in the environment. In recent years, global convection‐permitting models (GCPM) have been developed to circumvent problems arising from imposing artificial scale separation on physical processes associated with deep convection. Here, we use a global model in the convective gray zone that partially simulates deep convection to investigate how enhanced concentrations of aerosols that act as cloud condensate nuclei (CCN) impact tropical convection features by modulating the convection‐circulation interaction. Results from a pair of idealized non‐rotating radiative‐convective equilibrium simulations show that the enhanced CCN concentration leads to weaker large‐scale circulation, the closeness of deep convective systems to the moist cluster edges, and more mid‐level cloud water at an equilibrium state in which convective self‐aggregation occurred. Correspondingly, the enhanced CCN concentration modulates how the physical processes that support or oppose convective aggregation maintain the aggregated state at equilibrium. Overall, the enhanced CCN concentration facilitates the development of deep convection in a drier environment but reduces mean precipitation. Our results emphasize the importance of allowing atmospheric phenomena to evolve continuously across spatial and temporal scales in simulations when investigating the response of tropical convection to changes in cloud microphysics.
CloudSat Observations Show Enhanced Moisture Transport Events Increase Snowfall Rate and Frequency Over Antarctic Ice Sheet Basins
Authors: Rendfrey Tristan S. , Pettersen Claire , Bassis Jeremy N. , Mateling Marian E. 
Published: March 2024

AbstractElevated moisture transport over the Antarctic ice sheet can increase snowfall and ice mass. Previous studies used ground‐based observations, reanalysis products, and atmospheric models to evaluate the relationship between extreme moisture transport and snowfall properties. Here, we build on previous studies by combining reanalysis and CloudSat radar snowfall retrievals to examine impacts of extreme moisture intrusions on changes in snowfall frequency and intensity over glacier basins on the Antarctic ice sheet. We examine the impacts of enhanced moisture transport events on snowfall frequency and intensity over two different regions on the Antarctic ice sheet: the Amery Ice Shelf of East Antarctica and the Thwaites and Pine Island glacier basins of West Antarctica. We determine when the median integrated water vapor transport from reanalysis exceeds the 95th percentile within the glacier basins of interest to define enhanced moisture transport events. We then use CloudSat radar snowfall retrievals to evaluate differences between snowfall frequency and intensity during enhanced water vapor transport events compared to the seasonal means for 2007–2010. We find that enhanced moisture transport events over the Amery Ice Shelf and Thwaites and Pine Island glacier basins coincide with higher snowfall frequency and intensity. These enhanced moisture transport events have the potential to alter surface mass balance within glacier basins, with implications for future rates of sea level rise.
Weathering Incongruence in Mountainous Mediterranean Climates Recorded by Stream Lithium Isotope Ratios
Authors: Golla Jon K. , Bouchez Julien , Kuessner Marie L. , Druhan Jennifer L. 
Published: March 2024

AbstractLithium isotope ratios (δ7Li) of rivers are increasingly serving as a diagnostic of the balance between chemical and physical weathering contributions to overall landscape denudation rates. Here, we show that intermediate weathering intensities and highly enriched stream δ7Li values typically associated with lowland floodplains can also describe small upland watersheds subject to cool, wet climates. This behavior is revealed by stream δ7Li between +22.4 and +23.5‰ within a Critical Zone observatory located in the Cévennes region of southern France, where dilute stream solute concentrations and significant atmospheric deposition otherwise mask evidence of incongruence. The water‐rock reaction pathways underlying this behavior are quantified through a multicomponent, isotope‐enabled reactive transport model. Using geochemical characterization of soil profiles, bedrock, and long‐term stream samples as constraints, we evolve the simulation from an initially unweathered granite to a steady state weathering profile which reflects the balance between (a) fluid infiltration and drainage and (b) bedrock uplift and soil erosion. Enriched stream δ7Li occurs because Li is strongly incorporated into actively precipitating secondary clay phases beyond what prior laboratory experiments have suggested. Chemical weathering incongruence is maintained despite relatively slow reaction rates and moderate clay accumulation due to a combination of two factors. First, reactive primary mineral phases persist across the weathering profile and effectively “shield” the secondary clays from resolubilization due to their greater solubility. Second, the clays accumulating in the near‐surface profile are relatively mature weathering byproducts. These factors promote characteristically low total dissolved solute export from the catchment despite significant input of exogenous dust.
A Push in the Right Direction: Exploring the Role of Zealandia Collision in Eocene Pacific‐Australia Plate Motion Changes
Authors: Sandiford Dan , Betts Peter , Whittaker Joanne , Moresi Louis 
Published: March 2024

AbstractThe Pacific Plate underwent a significant change in motion during the early Eocene. This change has been linked to plate boundary reconfiguration, particularly in relation to subduction margins. The reconfiguration also resulted in a new Pacific‐Australian plate boundary section transecting Zealandia. Following the Eocene transition, the relative rotation axis was located within continental Zealandia, and it has been hypothesized that this region acted as a pivot point. Here we investigate the extent to which collision resistance along the intra‐continental Zealandia margin (length ∼1,000 km) might have impacted the motion of the Pacific Plate, which is characterized by trench lengths more than an order of magnitude greater. We first highlight the relatively large radial component in the Pacific Plate absolute rotation during the period ca. 47 and 32 Ma (i.e., the spin around the plate centroid axis). We then consider how parameterized plate boundary forces impact the tangential and radial components of the net torque (i.e., the fictitious and true torque components). We show that during this period, both the Zealandia and Izu‐Bonin‐Marianas (IBM) margins of the Pacific Plate were well‐oriented in terms of partitioning boundary normal forces into counter‐clockwise (CCW) radial torques. This analysis is supported by results from recent global‐scale numerical models. The role of Zealandia cannot be established unambiguously, based on our analysis, but effects can be quantified under different assumptions. Collision resistance along the Zealandia margin could plausibly constitute a “first order” effect on Eocene Pacific Plate rotation, albeit only on the radial component.
AURKA emerges as a vulnerable target for KEAP1-deficient non-small cell lung cancer by activation of asparagine synthesis
Authors: Deng Bing , Liu Fang , Chen Nana , Li Xinhao , Lei Jie , Chen Ning , Wu Jingjing , Wang Xuan , Lu Jie , Fang Mouxiang , Chen Ailin , Zhang Zijian , He Bin , Yan Min , Zhang Yuchen , Wang Zifeng , Liu Quentin 
Published: March 2024

AbstractAURKA is an established target for cancer therapy; however, the efficacy of its inhibitors in clinical trials is hindered by differential response rates across different tumor subtypes. In this study, we demonstrate AURKA regulates amino acid synthesis, rendering it a vulnerable target in KEAP1-deficient non-small cell lung cancer (NSCLC). Through CRISPR metabolic screens, we identified that KEAP1-knockdown cells showed the highest sensitivity to the AURKA inhibitor MLN8237. Subsequent investigations confirmed that KEAP1 deficiency heightens the susceptibility of NSCLC cells to AURKA inhibition both in vitro and in vivo, with the response depending on NRF2 activation. Mechanistically, AURKA interacts with the eIF2α kinase GCN2 and maintains its phosphorylation to regulate eIF2α-ATF4-mediated amino acid biosynthesis. AURKA inhibition restrains the expression of asparagine synthetase (ASNS), making KEAP1-deficient NSCLC cells vulnerable to AURKA inhibitors, in which ASNS is highly expressed. Our study unveils the pivotal role of AURKA in amino acid metabolism and identifies a specific metabolic indication for AURKA inhibitors. These findings also provide a novel clinical therapeutic target for KEAP1-mutant/deficient NSCLC, which is characterized by resistance to radiotherapy, chemotherapy, and targeted therapy.
FANCJ promotes PARP1 activity during DNA replication that is essential in BRCA1 deficient cells
Authors: Cong Ke , MacGilvary Nathan , Lee Silviana , MacLeod Shannon G. , Calvo Jennifer , Peng Min , Nedergaard Kousholt Arne , Day Tovah A. , Cantor Sharon B. 
Published: March 2024

AbstractThe effectiveness of poly (ADP-ribose) polymerase inhibitors (PARPi) in creating single-stranded DNA gaps and inducing sensitivity requires the FANCJ DNA helicase. Yet, how FANCJ relates to PARP1 inhibition or trapping, which contribute to PARPi toxicity, remains unclear. Here, we find PARPi effectiveness hinges on S-phase PARP1 activity, which is reduced in FANCJ deficient cells as G-quadruplexes sequester PARP1 and MSH2. Additionally, loss of the FANCJ-MLH1 interaction diminishes PARP1 activity; however, depleting MSH2 reinstates PARPi sensitivity and gaps. Indicating sequestered and trapped PARP1 are distinct, FANCJ loss increases PARPi resistance in cells susceptible to PARP1 trapping. However, with BRCA1 deficiency, the loss of FANCJ mirrors PARP1 loss or inhibition, with the detrimental commonality being loss of S-phase PARP1 activity. These insights underline the crucial role of PARP1 activity during DNA replication in BRCA1 deficient cells and emphasize the importance of understanding drug mechanisms for enhancing therapeutic response.
The role of mountains in shaping the global meridional overturning circulation
Authors: Yang Haijun , Jiang Rui , Wen Qin , Liu Yimin , Wu Guoxiong , Huang Jianping 
Published: March 2024

AbstractThe meridional overturning circulation (MOC) in the ocean is a key player in the global climate system, while continental topography provides an essential backdrop to the system. In this study, we design a series of coupled model sensitivity experiments to investigate the influence of various mountain ranges on the global thermohaline circulation. The results highlight the influence of the Tibetan Plateau (TP) on the global thermohaline circulation. It emerges as a requisite for establishing the Atlantic MOC (AMOC) and a determining factor for the cessation of the Pacific MOC (PMOC). Additionally, the Antarctic continent plays a vital role in facilitating the TP to form the AMOC. While the formation of the AMOC cannot be attributed to any single mountain range, the TP alone can inhibit the PMOC’s development. By modifying the global hydrological cycle, the TP is likely to have been crucial in molding the global thermohaline circulation.
High-security learning-based optical encryption assisted by disordered metasurface
Authors: Yu Zhipeng , Li Huanhao , Zhao Wannian , Huang Po-Sheng , Lin Yu-Tsung , Yao Jing , Li Wenzhao , Zhao Qi , Wu Pin Chieh , Li Bo , Genevet Patrice , Song Qinghua , Lai Puxiang 
Published: March 2024

AbstractArtificial intelligence has gained significant attention for exploiting optical scattering for optical encryption. Conventional scattering media are inevitably influenced by instability or perturbations, and hence unsuitable for long-term scenarios. Additionally, the plaintext can be easily compromised due to the single channel within the medium and one-to-one mapping between input and output. To mitigate these issues, a stable spin-multiplexing disordered metasurface (DM) with numerous polarized transmission channels serves as the scattering medium, and a double-secure procedure with superposition of plaintext and security key achieves two-to-one mapping between input and output. In attack analysis, when the ciphertext, security key, and incident polarization are all correct, the plaintext can be decrypted. This system demonstrates excellent decryption efficiency over extended periods in noisy environments. The DM, functioning as an ultra-stable and active speckle generator, coupled with the double-secure approach, creates a highly secure speckle-based cryptosystem with immense potentials for practical applications.
Tunable anisotropic van der Waals films of 2M-WS2 for plasmon canalization
Authors: Xing Qiaoxia , Zhang Jiasheng , Fang Yuqiang , Song Chaoyu , Zhao Tuoyu , Mou Yanlin , Wang Chong , Ma Junwei , Xie Yuangang , Huang Shenyang , Mu Lei , Lei Yuchen , Shi Wu , Huang Fuqiang , Yan Hugen 
Published: March 2024

AbstractIn-plane anisotropic van der Waals materials have emerged as a natural platform for anisotropic polaritons. Extreme anisotropic polaritons with in-situ broadband tunability are of great significance for on-chip photonics, yet their application remains challenging. In this work, we experimentally characterize through Fourier transform infrared spectroscopy measurements a van der Waals plasmonic material, 2M-WS2, capable of supporting intrinsic room-temperature in-plane anisotropic plasmons in the far and mid-infrared regimes. In contrast to the recently revealed natural hyperbolic plasmons in other anisotropic materials, 2M-WS2 supports canalized plasmons with flat isofrequency contours in the frequency range of ~ 3000-5000 cm−1. Furthermore, the anisotropic plasmons and the corresponding isofrequency contours can be reversibly tuned via in-situ ion-intercalation. The tunable anisotropic and canalization plasmons may open up further application perspectives in the field of uniaxial plasmonics, such as serving as active components in directional sensing, radiation manipulation, and polarization-dependent optical modulators.
Image rectangling network based on reparameterized transformer and assisted learning
Authors: Yang Lichun , Tian Bin , Zhang Tianyin , Yong Jiu , Dang Jianwu 
Published: March 2024

AbstractStitched images can offer a broader field of view, but their boundaries can be irregular and unpleasant. To address this issue, current methods for rectangling images start by distorting local grids multiple times to obtain rectangular images with regular boundaries. However, these methods can result in content distortion and missing boundary information. We have developed an image rectangling solution using the reparameterized transformer structure, focusing on single distortion. Additionally, we have designed an assisted learning network to aid in the process of the image rectangling network. To improve the network’s parallel efficiency, we have introduced a local thin-plate spline Transform strategy to achieve efficient local deformation. Ultimately, the proposed method achieves state-of-the-art performance in stitched image rectangling with a low number of parameters while maintaining high content fidelity. The code is available athttps://github.com/MelodYanglc/TransRectangling.
Imaging of 3 bright terrestrial gamma-ray flashes by the atmosphere-space interactions monitor and their parent thunderstorms
Authors: van der Velde Oscar A. , Navarro-González Javier , Fabró Ferran , Reglero Víctor , Connell Paul , Chanrion Olivier , López Jesús A. , Montanyà Joan , Neubert Torsten , Østgaard Nikolai 
Published: March 2024

AbstractThe Atmosphere-Space Interactions Monitor (ASIM) on the International Space Station (ISS) includes an instrument designed to geolocate Terrestrial Gamma-ray Flashes (TGF) produced by thunderstorms. It does so with a coded aperture system shadowing the pixelated Low Energy Detector of the Modular X- and Gamma-ray Sensor (MXGS). Additionally, it locates associated lightning flashes with the Modular Multispectral Imaging Array (MMIA). Here we present 3 bright TGFs with very similar duration, fluency and observation distance. The innovative imaging capabilities allow us to determine the TGF position and correlate the TGF-lightning parent event in time and position simultaneously. The accurate position determination and distance to the observer allow us to perform a comparative study of TGF characteristics. These TGFs were produced in association with lightning flashes below the highest cloud tops of developing to mature convective cells. In one event, GLM (Geostationary Lightning Mapper) cloud flash rates were slowing down after the TGF while negative cloud-to-ground flashes suddenly ceased from 10 to 5 min before the TGF. An 8-stroke (strongest: -93 kA) cloud-to-ground flash occurred 31 s before the TGF. Vertical profiles from the ERA5 reanalysis data suggest TGFs may be produced in variety of tropical environments.
Lentiviral mediated delivery of CRISPR/Cas9 reduces intraocular pressure in a mouse model of myocilin glaucoma
Authors: Patil Shruti V. , Kaipa Balasankara Reddy , Ranshing Sujata , Sundaresan Yogapriya , Millar J. Cameron , Nagarajan Bhavani , Kiehlbauch Charles , Zhang Qihong , Jain Ankur , Searby Charles C. , Scheetz Todd E. , Clark Abbot F. , Sheffield Val C. , Zode Gulab S. 
Published: March 2024

AbstractMutations in myocilin (MYOC) are the leading known genetic cause of primary open-angle glaucoma, responsible for about 4% of all cases. Mutations in MYOC cause a gain-of-function phenotype in which mutant myocilin accumulates in the endoplasmic reticulum (ER) leading to ER stress and trabecular meshwork (TM) cell death. Therefore, knocking out myocilin at the genome level is an ideal strategy to permanently cure the disease. We have previously utilized CRISPR/Cas9 genome editing successfully to target MYOC using adenovirus 5 (Ad5). However, Ad5 is not a suitable vector for clinical use. Here, we sought to determine the efficacy of adeno-associated viruses (AAVs) and lentiviruses (LVs) to target the TM. First, we examined the TM tropism of single-stranded (ss) and self-complimentary (sc) AAV serotypes as well as LV expressing GFP via intravitreal (IVT) and intracameral (IC) injections. We observed that LV_GFP expression was more specific to the TM injected via the IVT route. IC injections of Trp-mutant scAAV2 showed a prominent expression of GFP in the TM. However, robust GFP expression was also observed in the ciliary body and retina. We next constructed lentiviral particles expressing Cas9 and guide RNA (gRNA) targeting MYOC (crMYOC) and transduction of TM cells stably expressing mutant myocilin with LV_crMYOC significantly reduced myocilin accumulation and its associated chronic ER stress. A single IVT injection of LV_crMYOC in Tg-MYOCY437H mice decreased myocilin accumulation in TM and reduced elevated IOP significantly. Together, our data indicates, LV_crMYOC targets MYOC gene editing in TM and rescues a mouse model of myocilin-associated glaucoma.
Optimising the manufacturing of a β-Ti alloy produced via direct energy deposition using small dataset machine learning
Authors: Brooke Ryan , Qiu Dong , Le Tu , Gibson Mark A. , Zhang Duyao , Easton Mark 
Published: March 2024

AbstractSuccessful additive manufacturing involves the optimisation of numerous process parameters that significantly influence product quality and manufacturing success. One commonly used criteria based on a collection of parameters is the global energy distribution (GED). This parameter encapsulates the energy input onto the surface of a build, and is a function of the laser power, laser scanning speed and laser spot size. This study uses machine learning to develop a model for predicting manufacturing layer height and grain size based on GED constituent process parameters. For both layer height and grain size, an artificial neural network (ANN) reduced error over the data set compared with multi linear regression. Layer height predictions using ANN achieved an R2 of 0.97 and a root mean square error (RMSE) of 0.03 mm, while grain size predictions resulted in an R2 of 0.85 and an RMSE of 9.68 μm. Grain refinement was observed when reducing laser power and increasing laser scanning speed. This observation was successfully replicated in another α + β Ti alloy. The findings and developed models show why reproducibility is difficult when solely considering GED, as each of the constituent parameters influence these individual responses to varying magnitudes.
Theory of mind in chronic migraine with medication overuse assessed with the MASC
Authors: Bottiroli Sara , Rosi Alessia , Lecce Serena , Sances Grazia , Allena Marta , De Icco Roberto , Vecchi Tomaso , Tassorelli Cristina , Cavallini Elena 
Published: March 2024

AbstractTheory of Mind (ToM) is the ability to infer one's own and others' mental states. Growing research indicates that ToM is impaired in Chronic Migraine with Medication Overuse (CM + MO). However, the research in this field has been conducted using static scenario-based tasks, often failing to test mentalization in everyday situations and measuring only performance accuracy. We filled this gap by administering the Movie for the Assessment of Social Cognition (MASC) to subjects with CM + MO compared to episodic migraine (EM). This test allows us to assess both affective and cognitive ToM and which, in addition to being accurate, also analyzes the type of error in attribution of mental states, distinguishing between hypo-mentalization and hyper-mentalization. Thirty patients suffering from CM + MO and 42 from EM were enrolled. Results showed that CM + MO patients were less accurate in mental state attribution than EM. In addition, compared to EM, CM + MO individuals were more impaired in the affective ToM dimensions and committed more errors of hypo-mentalization. In conclusion, the application of MASC in patients with CM + MO allowed for the detection of an alteration in their ability to correctly draw conclusions about other people's mental states. This latter contributes critically to appropriate social reactions and also, possibly, to satisfactory social interactions.