bluuebunny/crossref_metadata_2025_split huggingface dataset:
TETRACYCLINE MOUTHWASH AS ORAL CAVITY ULCER THERAPY IN PATIENTS WITH A HISTORY OF ALLERGIES
Authors: Lukisari Cane , Setyaningtyas Dwi , Nafi’ah Nafi’ah , Apriasari Maharani Laillyza 
Published: April 2024

Background: One of the allergic reactions in the oral mucosa is ulceration caused by IgE-mediated reactions to food substances or non-IgE-mediated reactions and non-immunological mechanisms. Ulceration is a damage to the epithelium of the oral cavity that affects the nerve endings in the lamina propria layer so that it causes pain or heat that requires treatment and therapy. Objective: To report the occurrence of ulcers due to food allergies and therapy with tetracycline mouthwash 0.25% solution. Case: A 22-year-old female patient came with complaints of a small ulcer on the inside of the gums and the entire upper and lower lips and a numb and dry tongue. The patient always experiences an ulcer every time he eats seafood and certain foods that the patient cannot mention because it happens so often and every time an ulcer appears it will continue to get bigger. Management: Patients are advised to avoid allergens and refer for a complete blood allergy test and Ig E. Tetracycline mouthwash 0.25% solution was given to be rinsed three times a day. And added supportive therapy, giving multivitamins. Conclusion: Tetracycline mouthwash has antimicrobial properties and properties as inhibitors of tissue metalloproteinases (TIMPs) can accelerate healing time and ulceration does not continue to get bigger, reduce taste and pain, according to the theory it can reduce secondary speed limits and duration. inhibits collagenase. Keyword: Allergy, Mouthwash, Tetracycline, Ulcer
RELATIONSHIP OF SMOKING HABITS AND COFFEE CONSUMPTION WITH TEETH DISCOLORATION IN ALALAK BANJARMASIN
Authors: Adhani Rosihan , Putri Rizqi Risfiana , Budipramana Melisa 
Published: April 2024

Background: Teeth discoloration is a problem in dental practice, among others, the occurrence of teeth discoloration in coffee consumers as much as 77.13%, smokers who experience discoloration 76.7%. Based on data from Riskesdas South Kalimantan in 2018, the prevalence of daily smokers in Banjarmasin City is 18.02%. The highest smoking prevalence is in the population aged 30-34 years, which is 30.01%. Teeth discoloration is affected by extrinsic stains through the deposition of chromogenic materials on the teeth surface such as tobacco, tea and coffee. Teeth discoloration can cause discomfort when speaking, smiling and lack of confidence. Purpose: To analyze the relationship between smoking habits and coffee consumption with teeth discoloration in people aged 30-34 years in Alalak Tengah Village. Method: This research is an analytic observational with a cross sectional approach. The sampling technique used is probability sampling technique with a sample size of 87 people. Result: there was a significant relationship between the number of cigarettes and teeth discoloration 0.018 (p<0.05), the relationship between smoking duration and teeth discoloration was 0.006 (p<0.05), a significant relationship between the type of cigarette and teeth discoloration was 0.002 (p<0.05) and vice versa. There is no significant relationship between coffee consumption and duration of drinking coffee with teeth discoloration. Conclusion: Based on the research, there is a relationship between smoking habit and teeth discoloration. Keywords: Cigarettes, Coffee, Teeth Discoloration.
ELSABAGH SCORING SYSTEM FOR ASSESSING SEVERITY AND TREATMENT IMPROVEMENT IN MULTIPLE ORAL LICHEN PLANUS
Authors: Permatasanti Ayu , Hapid M. Hasan , Hidayat Wahyu 
Published: April 2024

Introduction: Lichen planus (LP) is a mucocutaneous, chronic, autoimmune disease, with various clinical manifestations, often involving the oral mucosa, and commonly occurs in adults 30-60 years old. Among the various scoring systems for oral lichen planus, the Elsabagh scoring system is valid, accurate, relatively easier to teach, relatively faster to master, and does not require complex calculations.Objective: This paper aimed to report and evaluate the successful therapy given based on using the Elsabagh scoring system in oral lichen planus. Case: A 53-years-old woman came to the Department of Oral Medicine with a main complaint of pain in the upper gums and lower right left a year ago. The pain got worse when eating highly spiced and spicy foods. She felt pain when brushing her teeth. Extra oral examination revealed multiple white plaques on the vermilion border. Intra-oral examination revealed erosive, erythema, accompanied by white plaques mesh-like shaped, irregular, and painful, on the upper labial, right and left buccal mucosa, posterior teeth of the mandible that extend into the mucobuccal fold, and gingiva, palate, and posterior gingiva of the right and left maxillae. Amalgam fillings were found on teeth 37 and 46 with plaque and calculus. Based on clinical features, the patient was diagnosed with Multiple Oral Lichen Planus of Erosive and Reticular type. Case management: The patient received topical and systemic corticosteroids, mouthwashes, and supplements. She was advised to stop eating highly spiced and spicy foods, replace amalgam filling with tooth-colored filling, scaling, and replace removable dentures with permanent dentures. The evaluation result using the Elsabagh scoring system showed an improvement from the value of 8 on the initial visit to 3 on the last visit. There was an improvement in the patient's condition after treatment based on evaluation using the Elsabagh scoring system in this case. The Elsabagh scoring system can correlate disease severity with subjective symptoms, allowing comparisons between the initial evaluation of lesions and treatment efficacy or disease progression in oral lichen planus. Keywords: Autoimmune, Elsabagh Scoring System, Oral Lichen Planus
ENDODONTIC TREATMENT ON FRACTURED MANDIBULAR ANTERIOR TOOTH WITH CROWN DOWN TECHNIQUE
Authors: Putri Lesmana Raisya Aurellia , Fatriadi Fajar 
Published: April 2024

Background: Trauma involving the dento-alveolar area often occurs and tends to cause tooth fractures. Fractured teeth can be at risk of infection which can lead to pain and tooth necrosis. In necrotic tooth cases, root canal treatment is one of the most common procedures to be performed to preserve the tooth. Case: A 36-year-old female patient came to RSGM Unpad with chief complaint of a broken mandibular anterior tooth. This complaint occurred 3 months ago. The patient did not complain of any pain. Previously, the tooth that the patient complained about had been restored but fell out again a month ago. History of systemic disease, family disease, and allergies was denied. Patients want their complaints to be resolved. Case Management: The treatment carried out in this case is root canal treatment. Root canal treatment consists of three main stages, namely biomechanical preparation of the root canal, root sterilization with calcium hydroxide, and obturation. The preparation technique used is crown down. The main aim of the crown down root canal preparation technique is to minimize or eliminate the amount of extruded necrotic tissue towards the apical foramen during preparation. Conclusion: Establishing a good diagnosis, as well as the use of good instrumentation in root canal treatment with a crown down preparation technique followed by single cone obturation can be an option for treating crown fracture teeth. Further follow-up is required in this case. Keywords: crown down, fracture, nonvital, root canal treatment
Antibacterial activity of Cassia alata stems ethanol extract against Staphylococcus aureus
Authors: Mar'ie Ahmad Mahdi , Zamzani Irfan , Nashihah Siti 
Published: April 2024

Background: Cassia alata leaves, also known as petai cina or gelinggang in Indonesia, are commonly used to treat skin ailments.
Objective: The purpose of this study is to test whether stem of C. alata has antibacterial activity against Staphylococcus aureus.
Methods: C. alata stems were extracted using an ultrasound-assisted extraction method. For antibacterial activity, disc diffusion was used with extract concentrations of 25%, 50%, 75%, and 100%.
Results: The inhibition zones of the ethanol extract of C. alata stems at 25%, 50%, and 75% concentrations were 17.6 mm, 21 mm, and 22.6 mm, respectively, with the highest inhibition zone at 100% concentration at 25 mm.
Conclusion: The ethanolic extract of C. alata stems has a strong inhibitory effect on Staphylococcus aureus.
Cempedak leaf extract (Artocarpus champeden) as a novel ingredient in antibacterial peel-off gel face masks
Authors: Putri Faizah Alivia , Widia Widia , Syarmila Syarmila , Mahardika Robby Gus 
Published: April 2024

Background: Phenolic compounds in plants act as natural antioxidants, with cempedak (Artocarpus champeden) leaf extract showing promise due to its high phenolic content and potential antibacterial properties against Propionibacterium acnes.
Objective: This study explores the effectiveness of cempedak leaf extract as an active ingredient in peel-off gel face masks for antibacterial purposes.
Methods: Cempedak leaf extract was analyzed for phenolic content and Fourier transform infrared (FTIR). Its antibacterial activity was tested against P. acnes using agar diffusion, comparing inhibition zones with positive control. A peel-off gel face mask was formulated with cempedak leaf extract, undergoing physical and an irritation test.
Results: Cempedak leaf extract contained a total phenolic content of 342.35 mg EAG/g and exhibited significant antibacterial activity. The face mask formulation with cempedak leaf extract showed promising physical properties and did not irritate, meeting the peel-off gel face mask standards.
Conclusion: Cempedak leaf extract has potent antibacterial properties, making it an effective ingredient in peel-off gel face masks for treating acne. Further research could explore its commercial potential in skincare products.
Antifungal activity of Calophyllum soulattri leaf extract on fungal isolate of coconut neera
Authors: Rachmani Eka Prasasti Nur , Baroroh Hanif Nasiatul , Rehana Rehana , Rahmawati Novia Ayu 
Published: April 2024

Background: Coconut neera is susceptible to fungus contamination. Some plants, such as Calophyllum soulattri, can function as natural preservatives with antifungal properties.
Objective: This study aimed to evaluate the antifungal activity of C. soulattri leaf extract as measured by minimum inhibitory concentration (MIC) and minimum killing concentration (MKC).
Methods: A dilution method was used to isolate the fungus that contaminated coconut neera. MIC and MKC antifungal activity were then evaluated using the liquid dilution method.
Results: The results indicated that the contaminant fungi found in coconut neera belonged to the genus Penicillium. The MIC was 12.5%, while the MKC was 18.75%.
Conclusion: C. soulattri leaf extract has the potential to be developed as an antifungals for food preservation.
Cost-effectiveness analysis of lopinavir, ritonavir, and nevirapine toward HIV AIDS patients as antiretroviral: a systematic review
Authors: Pratama Anggara Martha , Pramestutie Hananditia Rachma , Krisnadewi Kadek Ida , Pratiwi Hening 
Published: April 2024

Background: The mobilization of resources to prevent and treat human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS) is unparalleled in the history of public health. Nevirapine resistance may decrease the effectiveness of viral suppression with nevirapine-based HIV in women infected with human immunodeficiency virus (HIV) with previous exposure to single-dose nevirapine. However, the alternative lopinavir/ritonavir–based antiretroviral therapy (ART) regimen is more expensive.
Objective: Our objectives were to project the tradeoffs regarding the cost-effectiveness of ART regimens for nevirapine-exposed and lopinavir/ritonavir.
Methods: A thorough literature search was conducted using PubMed and SAGE databases, employing search terms such as “cost-effectiveness analysis,” AND “HIV AIDS,” AND “lopinavir,” OR “ritonavir,” AND “nevirapine.” Additionally, hand searches were carried out on Google Scholar with various combinations of these terms to ensure comprehensive coverage of relevant studies.
Results: Six studies met the our inclusion criteria and were reviewed. The analysis confirms that both nevirapine and lopinavir/ritonavir-based ART regimens are cost effective in a range of settings, despite differences in their relative efficacy and contexts in which they are used.
Conclusion: This systematic review collates recent studies on the cost-effectiveness of nevirapine and lopinavir/ritonavir in ART. It showed that in this finding, there are cost effective but this article had wide variation with comparison therapy. Cost-effectiveness results depended on the relative efficacy of lopinavir/ritonavir and nevirapine in both first-line and second-line ART.
Synthesis of Some New Amino Carbonyl Compounds by Mannich Reaction
Authors: Dawood Nagham , Saeed Banan , Saeed Zainab 
Published: April 2024

Beta-aminocarbonyl compounds are important intermediates produced from Mannich condensation. In this research, benzaldehyde, para-hydroxy acetophenone or para-nitro acetophenone were reacted with a various of primary aromatic amines to give compounds (1-7) and (8-14), respectively. The chemical formulas of the synthesized compounds were confirmed by conducting some physical and spectroscopic measurements, such as, melting points, IR and H1-NMR spectrum. After testing the biological activity of some of the synthesized compounds (8,10,11,13) using Gram-positive (Streptococcus, and Staphylococcus aureus), Gram-negative (Klebsiella spp., and Escherichia coli) bacteria, as well as yeast strains, were chosen for this investigation (candidan albicans). Isolated bacteria were identified using standard methods of isolation and identification, including direct assays and culture on various media. Some theoretical tests have also been carried out such as SwissADME and cardioToxCSM prediction on all prepared compounds to predict their activity in terms of pharmacokinetic properties (ADME) and also predict their cardiotoxicity on some heart functions such as arrhythmia, cardiac failure, heart block, hERG toxicity, Hypertension (HT), and Myocardial Infarction (MI).

Keywords: Secondary amines, aldehyde, Mannich condensation, antimicrobial activity.
Clinical, electrical, and functional changes following CRT-P implantation: short-term results in patients with non-ischaemic cardiomyopathy
Authors: Mostafa S. A. , Abdelmoneim A. М. , Ramadan H. , Elkeshk E. S. 
Published: April 2024

Aim. Assessment of the correlation between cardiac remodeling, functional status and electrical remodeling after cardiac resynchronisation therapy (CRT) in patients with non-ischaemic cardiomyopathy.Material and methods. A single center, prospective, observational study included 50 patients with non-ischaemic cardiomyopathy who were candidate for CRT implantation. All patients prior to CRT and then 3 months after implantation had standard 12-lead surface ECGs to assess QRSd for assessment electrical response, for assessment of left ventricular ejection fraction (LVEF) and volumes (left ventricular end diastolic and systolic volume, LVEDV and LVESV), mitral regurgitation (degree of mitral regurgitation), pulmonary artery systolic pressure (for diagnosis of pulmonary hypertension), NYHA class and 6 minute walk test (6MWT) to assess patient’s functional capacity.Results. 50 patients with CRT were included (35 males and 15 females, mean age 54.88±7.48 years). All patients were in sinus rhythm with QRS duration (QRSd) ≥120 ms, EF<35% and left bundle branch block. After 3 months; there was significant improvement in QRSd in 82% of the cases (145.3±16.3 ms vs 133.3±17.2 ms, p<0.001). NYHA class improved at least one class in 78% and 6 min walk test improved in 80% (168.5 [131.0; 181.0] m vs 280.0 [237.0; 297.0] m, p<0.001). LVEF increased significantly in 74% of study cases (28.6±2.7 vs 34.5±3.1, p value 0.001) also there were statistically significant improvement in LVEDV (267.0±45.7 to 221.8±41.9 ml, p=0.002) and LVESV (137.43±47.19 to 105.03±42.7 ml, p=0.003). There was statistically significant correlation between QRSd and NYHA class (r=0.392, p=0.005), QRSd and 6MWT (r=0.323, p=0.022) and QRSd with LVEF (r=0.672 with p<0.001). Only seven patients showed improvement in the 3 parameters: LVESV, QRS duration and 6 min walk test.Conclusion. The CRT-pacemaker implantation was associated with significant improvement in QRSd, NYHA class, 6MWT and LV volumes in the short-term period. QRSd improvement was significantly correlated with functional status and LV EF.
Femoroacetabular Variations Are Predisposing Factors for Traumatic Posterior Hip Dislocation
Authors: Regenbogen Stephan , Shafizadeh Sven , Märdian Sven , Blum Philipp , Osten Philipp , Fuchs Thomas , Jaecker Vera 
Published: April 2024

Background:
Although high-energy trauma mechanisms are generally considered to cause traumatic posterior hip dislocations, femoroacetabular variations are assumed to contribute to low-impact hip dislocations. Thus, the present study aimed to identify morphologic femoral and acetabular risk factors that may also contribute to posterior hip dislocations in high-energy trauma mechanisms.

Methods:
The acetabular and femoral morphology of 83 hips with a traumatic posterior dislocation following a high-energy trauma mechanism were analyzed and matched to a control group of 83 patients who sustained high-energy trauma without a hip injury. The lateral center-edge angle, acetabular index, acetabular depth/width ratio, cranial and central acetabular version angles, and the anterior and posterior acetabular sector angles were measured on computed tomography to quantify femoroacetabular impingement (FAI) morphology, acetabular version, and coverage. The caput-collum-diaphyseal angle and the alpha angles in the coronal and axial planes were measured to detect cam-type FAI deformity. A receiver operating characteristic curve was utilized to determine threshold values for an increased risk of hip dislocation.

Results:
Acetabular retroversion and posterior acetabular undercoverage were significantly increased in patients with hip dislocations compared with controls (p < 0.001). The central acetabular version angle and posterior acetabular sector angle that indicated an increased risk of hip dislocation were ≤9° and ≤90°, respectively. Cam-type FAI deformity and coxa valga were significantly increased in the dislocation group (p < 0.001). The anterolateral alpha angle that indicated an increased dislocation risk was ≥47°.

Conclusions:
Acetabular retroversion, posterior acetabular undercoverage, and cam-type FAI morphology may be risk factors contributing to traumatic posterior hip dislocation in high-energy trauma mechanisms.

Level of Evidence:
Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
AOA Critical Issues: Promoting Leadership Development Among Orthopaedic Faculty
Authors: Burger Evalina , Ghanayem Alexander , Mulcahey Mary K. 
Published: April 2024

Abstract:
All orthopaedic surgeons are leaders in the operating room and clinic, and many orthopaedic surgeons choose to pursue other formal leadership roles. Effective leaders are proficient communicators, have high emotional intelligence, have a growth mindset, create structure, and facilitate teamwork. Participating in formal leadership training offered through the American Orthopaedic Association, the American Academy of Orthopaedic Surgeons, or advanced degree programs can facilitate the development of leadership skills. By setting goals, being aware of available leadership positions, and promoting diversity, senior leaders may help orthopaedic faculty to achieve senior leadership roles. Maxwell’s leadership hierarchy, which consists of 5 levels of leadership (position, permission, production, people development, and pinnacle), provides a framework for the promotion and mentorship of junior partners by senior leaders. Seeking out and promoting leadership will encourage an environment of leaders and improve the field of orthopaedic surgery.
TAPHONOMIC ANALYSIS OF AN ARTICULATED BALEEN WHALE (CETACEA; MYSTICETI) FROM UPPER MIOCENE INNER SHELF DEPOSITS OF PENÍNSULA VALDÉS, PATAGONIA, ARGENTINA
Authors: FARRONI NICOLÁS DANIEL , CUITIÑO JOSÉ IGNACIO , LAZO DARÍO GUSTAVO , BUONO MÓNICA ROMINA 
Published: April 2024

Abstract
Fieldwork at Península Valdés (Chubut, Argentina) in the Puerto Madryn Formation (Late Miocene) resulted in the discovery of a well-preserved, almost fully articulated, baleen whale (Cetacea, Mysticeti). This specimen, one of the most complete balaenid skeletons known from the Neogene of Argentina and worldwide, was the focus of a taphonomic analysis employing a multidisciplinary approach, integrating taxonomic, sedimentological, stratigraphic, and ichnological analyses, with the aim of reconstructing the taphonomic processes and the paleoenvironmental conditions that controlled preservation of the specimen. The skeleton belongs to the family Balaenidae (right whales). It displays a high degree of articulation, moderate pre-burial fragmentation, and relatively high completeness. Our results suggest that after death, the balaenid suffered a brief biostratinomic phase that can be summarized in four stages: (1) death at sea, with initial decomposition and positive buoyancy of the carcass; (2) internal accumulation of putrefaction gases, re-orientation, then gas loss; (3) sinking and deposition in a ventral-up position on the sea floor of the inner shelf; and (4) lateral re-orientation of the postcranial region due to physical and biological processes. The high degree of articulation and association of the skeletal elements, and the presence of both mandibles, indicate no lateral transport on the seabed and excludes refloating of the carcass at any stage. Finally, the data indicate a low-energy shelf environment with normal marine benthic oxygenation and salinity conditions, characterized by a soft bottom and a moderate sedimentation rate. The last, combined with high bioturbation, plus scour-induced self-burial, resulted in rapid burial of the carcass.
Unique Multicomponent Fe, Mn, Ti, V Mineralization in Laterite Profiles of Weathered Carbonatites: New Prospects
Authors: Lapin A.V. , Tolstov A.V. , Nabelkin O.A. , Kulikova I.M. 
Published: April 2024

Abstract
—Data from the Chuktukon, Tomtor (Russia), and Morro dos Seis Lagos (Brazil) mineral deposits demonstrate that the mineral potential of laterite produced by weathering of carbonatites can be extended with Fe, Mn, Ti, and V, which are commonly beyond the conventional ore production. Several previously unknown factors have been revealed, which control the mineral potential of laterite: reduction of weathering products, composition and ore contents of carbonatite, lateral and vertical migration of elements, as well as liquid fractionation of colloids in upper zones of weathering profiles. The reported study provides additional arguments for the idea that laterite derived from carbonatites stores unique multicomponent mineralization of heavy lanthanides, Y, Sc, Fe, Mn, Ti, V, Sr, Ba, Al, and Ga, besides the common target commodities of Nb, La, Ce, and P.