bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of sustainable investment policies for housing demand in Qatar via hybrid quantum fuzzy decision-making model
Authors: Fetais Alanoud , Dincer Hasan , Yüksel Serhat , Aysan Ahmet 
Published: April 2024

PurposeThis study aims to evaluate sustainable investment policies for housing in Qatar.Design/methodology/approachThis paper proposes a new model for analyzing sustainable investment policies for housing demand in Qatar via a hybrid quantum fuzzy decision-making model. The study processed the criteria with the facial expression-based Quantum Spherical fuzzy DEMATEL and ranked the alternatives with the facial expressions-based quantum spherical fuzzy TOPSIS. Four factors were determined due to a comprehensive literature review (Environment, Housing Design, Building Design, and Surrounding the building), with five sustainable investment policy alternatives (Electricity production with renewable energies, Recycling systems and materials in construction, Transport with less carbon emission, Biodiversity for residents, and Resilience to natural disasters).FindingsThe analysis indicates that the design of the building is the most important factor (0.254), while the environment is the most influencing factor (0.253) regarding housing demand in Qatar. Transport with less carbon emission and electricity production with renewable energies are the most critical alternative investment policies.Originality/valueThis study provides useful insights for regulators, policymakers, and stakeholders in Qatar’s sustainable investment policies for housing demand. The main motivation of this study is that there is a need for a novel model to evaluate the sustainable investment policies for housing demand. The main reason is that existing models in the literature are criticized due to some issues. In most of these models, emotions of the experts are not taken into consideration. However, this situation has a negative impact on the appropriateness of the findings. Because of this situation, in this proposed model, facial expressions of the experts are considered. With the help of this issue, uncertainties in the decision-making process can be handled more effectively.
Harvesting insights: a qualitative exploration of facilitators, inhibitors and information seeking in family-based sustainable organic farm businesses
Authors: Lone Aashiq Hussain , Rashid Irfana 
Published: April 2024

PurposeThis study aims to investigate the landscape of family-based organic farm businesses in the Kashmir Valley, India, analyzing the factors that either facilitate or hinder their adoption. The research also intends to uncover sources of information seeking. The primary purpose is to provide qualitative evidence to address existing knowledge gaps and offer insights for promoting sustainable farm practices in the region.Design/methodology/approachThe research employs a qualitative approach, drawing on focus group interviews. The study thoroughly explores the background and relevant literature, utilizing a comprehensive research framework. Data is collected from family based farmers engaged in organic farming practices in the Kashmir Valley. The data is analyzed using content analysis ensuring a robust and thorough exploration of the subject matter.FindingsThis study reveals a notable transition in the agricultural landscape of the Kashmir Valley, showcasing a widespread adoption of organic farming on considerable land. The study reveals that key facilitators for organic farming among family-based farms are farm productivity, entrepreneurial intention, governance, environmental consciousness, and health concerns. The exchange of information, both through formal and informal channels, is found to be a crucial factor influencing the adoption of organic farming. The study also unveiled significant inhibitors that hinder the adoption of organic farming on commercial scales, including on-farm challenges such as difficulties in acquiring inputs and facing reduced yields, market-related concerns, and a lack of support and assistance from government agencies.Originality/valueThis research contributes significantly to the existing literature by advancing the understanding of organic farm business and agri-entrepreneurship. It unveils key factors that either support or hinder family-based organic farms, identifying crucial information sources and presenting valuable insights for policymakers. Furthermore, this study provides practical guidance for overcoming obstacles, enhancing infrastructure, and translating identified facilitators into successful agri-ventures in the Kashmir region.
Using semantic differential method to evaluate users’ olfactory perceptions in academic library
Authors: Yu Yingying , Su Wencheng , Lu Zhangping , Liu Guifeng , Ni Wenjing 
Published: April 2024

PurposeSpatial olfactory design in the library appears to be a practical approach to enhance the coordination between architectural spaces and user behaviors, shape immersive activity experiences and shape immersive activity experiences. Therefore, this study aims to explore the association between the olfactory elements of library space and users’ olfactory perception, providing a foundation for the practical design of olfactory space in libraries.Design/methodology/approachUsing the olfactory perception semantic differential experiment method, this study collected feedback on the emotional experience of olfactory stimuli from 56 participants in an academic library. From the perspective of environmental psychology, the dimensions of pleasure, control and arousal of users’ olfactory perception in the academic library environment were semantically and emotionally described. In addition, the impact of fatigue state on users’ olfactory perception was analyzed through statistical methods to explore the impact path of individual physical differences on olfactory perception.FindingsIt was found that users’ olfactory perception in the academic library environment is likely semantically described from the dimensions of pleasure, arousal and control. These dimensions mutually influence users’ satisfaction with olfactory elements. Moreover, there is a close correlation between pleasure and satisfaction. In addition, fatigue states may impact users’ olfactory perception. Furthermore, users in a high-fatigue state may be more sensitive to the arousal of olfactory perception.Originality/valueThis article is an empirical exploration of users’ perception of the environmental odors in libraries. The experimental results of this paper may have practical implications for the construction of olfactory space in academic libraries.
Administration mode matters for 5‐fluorouracil therapy: Physiologically based pharmacokinetic evidence for avoidance of myelotoxicity by continuous infusion but not intravenous bolus
Authors: Chao Chih‐Jia , Gardner Iain , Lin Chun‐Jung , Yeh Kun‐Huei , Lu Wan‐Chen , Abduljalil Khaled , Ho Yunn‐Fang 
Published: April 2024

AimsPre‐emptive prediction to avoid myelosuppression and harmful sequelae is difficult given the complex interplay among patients, drugs and treatment protocols. This study aimed to model plasma and bone marrow concentrations and the likelihood of myelotoxicity following administration of 5‐fluorouracil (5‐FU) by diverse intravenous (IV) bolus or continuous infusion (cIF) regimens.MethodsUsing physicochemical, in vitro and clinical data obtained from the literature consisting of various regimens and patient cohorts, a 5‐FU physiologically based pharmacokinetic (PBPK) model was developed. The predicted and observed PK values were compared to assess model performance prior to examining myelotoxicity potential of IV bolus vs. cIF and DPYD wild type vs. genetic variant.ResultsThe established model was verified by utilizing 5‐FU concentration–time profiles of adequate heterogeneity contributed by 36 regimens from 15 studies. The study provided corroborative evidence to explain why cIF (vs. IV bolus) had lower myelotoxicity risk despite much higher total doses. The PBPK model was used to estimate the optimal dosage in patients heterozygous for the DPYD c.1905 + 1G > A allele and suggested that a dose reduction of at least 25% was needed (compared to the dose in wild‐type subjects).ConclusionA verified PBPK model was used to explain the lower myelotoxicity risk of cIF vs. IV bolus administration of 5‐FU and to estimate the dose reduction needed in carriers of a DPYD variant. With appropriate data, expertise and resources, PBPK models have many potential uses in precision medicine application of oncology drugs.
Thirst and drugs: A study in the World Health Organization's pharmacovigilance database
Authors: Montastruc Jean‐Louis 
Published: April 2024

AbstractThirst is a complex physiological compensatory mechanism but could also be associated with drugs. This association was poorly investigated previously. Using the WHO global pharmacovigilance database, Vigibase®, disproportionality analyses potential associations between exposure to drugs and thirst reports were performed. All reports of thirst in adults between 01/01/2000 and 31/12/2023 were included. Results are expressed as reporting odds ratio (ROR). Analysis of the 3186 reports of thirst (978 ‘serious’) allowed, first, to confirm the association between thirst and exposure to vasopressin antagonists (tolvaptan), lithium, gliflozins (dapagliflozin, empagliflozin), pregabalin and antimuscarinic drugs (glycopyronium, oxybutynin, tiotropium). Second, new safety signals were described with monoamine reuptake inhibitors (antidepressants: duloxetine, venlafaxine; anti‐obesity agent: sibutramine), antipsychotic (olanzapine), glucocorticoid (prednisolone), diuretic (furosemide) drugs as well with ribavirin or sodium oxybate. This study is the first to offer a list of drugs associated with thirst in humans.
A cryptic syngameon withinBetulashrubs revealed: Implications for conservation in changing subarctic environments
Authors: Touchette Lyne , Godbout Julie , Lamothe Manuel , Porth Ilga , Isabel Nathalie 
Published: April 2024

AbstractArctic and subarctic ecosystems are rapidly transforming due to global warming, emphasizing the need to understand the genetic diversity and adaptive strategies of northern plant species for effective conservation. This study focuses onBetula glandulosa, a native North American tundra shrub known as dwarf birch, which demonstrates an apparent capacity to adapt to changing climate conditions. To address the taxonomic challenges associated with shrub birches and logistical complexities of sampling in the northernmost areas where species' ranges overlap, we adopted a multicriteria approach. Incorporating molecular data, ploidy level assessment and leaf morphology, we aimed to distinguishB. glandulosaindividuals from other shrub birch species sampled. Our results revealed three distinct species and their hybrids within the 537 collected samples, suggesting the existence of a shrub birch syngameon, a reproductive network of interconnected species. Additionally, we identified two discrete genetic clusters within the core species,B. glandulosa, that likely correspond to two different glacial lineages. A comparison between the nuclear and chloroplast SNP data emphasizes a long history of gene exchange between different birch species and genetic clusters. Furthermore, our results highlight the significance of incorporating interfertile congeneric species in conservation strategies and underscores the need for a holistic approach to conservation in the context of climate change, considering the complex dynamics of species interactions. While further research will be needed to describe this shrub birches syngameon and its constituents, this study is a first step in recognizing its existence and disseminating awareness among ecologists and conservation practitioners. This biological phenomenon, which offers evolutionary flexibility and resilience beyond what its constituent species can achieve individually, may have significant ecological implications.
Combined use of radiomics and artificial neural networks for the three‐dimensional automatic segmentation of glioblastoma multiforme
Authors: de los Reyes Alexander Mulet , Lord Victoria Hyde , Buemi Maria Elena , Gandía Daniel , Déniz Luis Gómez , Alemán Maikel Noriega , Suárez Cecilia 
Published: April 2024

AbstractGlioblastoma multiforme (GBM) is the most prevalent and aggressive primary brain tumour that has the worst prognosis in adults. Currently, the automatic segmentation of this kind of tumour is being intensively studied. Here, the automatic three‐dimensional segmentation of the GBM is achieved with its related subzones (active tumour, inner necrosis, and peripheral oedema). Preliminary segmentations were first defined based on the four basic magnetic resonance imaging modalities and classic image processing methods (multithreshold Otsu, Chan–Vese active contours, and morphological erosion). After an automatic gap‐filling post processing step, these preliminary segmentations were combined and corrected by a supervised artificial neural network of multilayer perceptron type with a hidden layer of 80 neurons, fed by 30 selected radiomic features of gray intensity and texture. Network classification has an overall accuracy of 83.9%, while the complete combined algorithm achieves average Dice similarity coefficients of 89.3%, 80.7%, 79.7%, and 66.4% for the entire region of interest, active tumour, oedema, and necrosis segmentations, respectively. These values are in the range of the best reported in the present bibliography, but even with better Hausdorff distances and lower computational costs. Results presented here evidence that it is possible to achieve the automatic segmentation of this kind of tumour by traditional radiomics. This has relevant clinical potential at the time of diagnosis, precision radiotherapy planning, or post‐treatment response evaluation.
Shared Placement and Parenting Stress Among Low‐Income Noncustodial Fathers
Authors: Costanzo Molly A. , Kim Yoona , Meyer Daniel R. 
Published: April 2024

AbstractObjectiveWe examine the relationship between shared placement and parenting stress for low‐income fathers.BackgroundShared placement (joint physical custody), a living arrangement in which children whose parents live apart spend a significant amount of time living with each, has increased among families in the United States. Little is known about how this placement affects fathers' well‐being, especially fathers with lower incomes and who have had a nonmarital birth.MethodOur sample included 5,755 noncustodial fathers who enrolled in the National Child Support Noncustodial Parent Employment Demonstration. Using regression approaches, we estimate associations between measures of self‐reported placement and parenting stress.ResultsWe found that shared placement was statistically significantly associated with lower parenting stress levels (estimated magnitude of 5%–10%) compared with fathers without shared placement. This held for fathers with equal placement and those with substantial, but not equal, time. These results were consistent when accounting for confounding characteristics, suggesting the association may not be fully explained by selection into shared placement.ConclusionShared placement is associated with lower levels of parenting stress for low‐income noncustodial fathers compared with those fathers without it. We find that this holds true for any shared placement, equal placement, mother primary shared placement, and father primary shared placement.ImplicationsGiven the potential benefits of shared care, examining whether policy and practice are supporting this for lower resourced families may be particularly important. Fatherhood and other family‐strengthening programs can support fathers in navigating potential stress driven by shared parenting arrangements.
Fillers impacting follicles: the emerging complication of filler‐induced alopecia
Authors: Pulumati Anika , Algarin Yanci , Jaalouk Dana , Latta Steven , Nouri Keyvan 
Published: April 2024

AbstractFiller‐induced alopecia is a transient alopecia characterized by localized hair loss and often attributed to vascular compromise following dermal filler injections in facial regions. Although an uncommon phenomenon, the rising incidence of filler‐induced alopecia underscores the importance of understanding and managing this condition. We performed an extensive PubMed review of articles reporting filler‐induced alopecia and summarizing the implicated filler types, injection areas, hair loss patterns, symptom onset, course progression, treatments, and prognosis. Hyaluronic acid injections were the most implicated in filler‐induced alopecia cases, with calcium hydroxylapatite and autologous fat less frequently associated. No cases involved other dermal filler types. Although recovery times varied depending on the treatment, hyaluronidase (HAase) injections rapidly restored near‐normal hair density within 3–4 months. Minoxidil and platelet‐rich plasma play a more minor role in restoring hair growth but may be used as adjuncts with HAase to facilitate hair growth. Finally, alternative interventions like intralesional triamcinolone, warm compresses, and nitroglycerin warrant exploration, given limited robust clinical data. Our study promotes awareness of filler‐induced alopecia's rising incidence and offers practical insights and evidence‐based recommendations for effective management. By equipping dermatologists with this knowledge, our aim is to improve patient outcomes and reduce adverse events in filler‐based procedures.
Mimicking the cellular environment does not cause monocyte‐derived macrophages to become phenotypically similar to Kupffer cells
Authors: Elchaninov Andrey , Vishnyakova Polina , Kuznetsova Maria , Lokhonina Anastasiya , Soboleva Anna , Trofimov Dmitry , Fatkhudinov Timur , Sukhikh Gennady 
Published: April 2024

AbstractResident macrophages of various mammalian organs are characterized by several distinctive features in their gene expression profile and phenotype, including involvement in the regulation of organ functions, as well as reduced sensitivity to proinflammatory activation factors. The reasons for the formation of such a specific phenotype remain the subject of intensive research. Some papers emphasize the role of the origin of organ macrophages. Other studies indicate that monocytes that develop in the red bone marrow are also able to form resident macrophages with a phenotype characteristic of a particular organ, but this requires appropriate microenvironmental conditions. In this article, we studied the possibility of differentiation of monocyte‐derived macrophages into cells with a Kupffer‐like phenotype under the influence of the main stromal components of Kupffer cells macrophage niche: Ito cells, liver sinusoid endotheliocytes and hepatocyte growth factor (HGF). It was found that Kupffer cells are characterized by several features, including increased expression of transcription factors Spic and Id3, as well as MUP family genes, Clusterin and Ngp genes. In addition, Kupffer cells were characterized by a higher proliferative activity. The expression of marker genes of Kupffer cells (i.e. Id3, Spic, Marco and Timd4) increased in monocyte‐derived macrophages during coculture with Ito cells, liver sinusoid endothelial cells, macrophage colony–stimulating factor and HGF cells only by 3 days. However, the expression level of these genes was always higher in Kupffer cells. In addition, a complete coincidence of the expressed gene profile in monocyte‐derived macrophages and Kupffer cells did not occur even after 3 days of culturing.
RETRACTED: An in‐depth analysis of wound incidence and injury status among professional athletes: A comprehensive review
Authors: Huang Xiaoqi , Wu Yuqing , Li Xin , Zhang Ming , Liu Yixiang 
Published: April 2024

AbstractThis review aims to synthesize current knowledge on the incidence, characteristics and management of wounds and injuries among professional ice hockey athletes, with the specific focus on the emerging population of Chinese female players. An extensive literature search was conducted across several databases to gather data on injury patterns and wounds, causes, severity and prevention strategies in ice hockey. Special attention was given to studies involving female athletes and unique challenges faced by players in developing regions like China. The review also examined the impact of training modalities, protective equipment and medical interventions on injury rates. The findings reveal a significant seasonal fluctuation in wound incidence, with marked reduction following the preseason period. This trend underscores the effectiveness of adjusted training programmes and essential role of medical teams in injury prevention and rehabilitation. Analysis did not show significant difference in wound rates between technical and physical training sessions, suggesting that injuries are pervasive risk across all training activities. Skating, collisions and inadequate warm‐ups were identified as the leading causes of wounds, highlighting areas for targeted preventive measures. The distribution of wounds across various body regions pointed to knee, lower back and wrist as the most vulnerable sites, necessitating focused protection and training adjustments. Ice hockey, particularly among female athletes in China, presents complex injury landscape characterized by the wide range of wounds. The study emphasizes the necessity of comprehensive, multidisciplinary approach to injury prevention that includes training modifications, enhanced protective gear and strategic medical oversight. By addressing the specific causes and patterns of injuries identified, stakeholders can better protect athletes from the inherent risks of the sport, promote safer play and extend career longevity.
The contribution of small heterodimer partner to the occurrence and progression of cholestatic liver injury
Authors: Wei Shizhang , Wang Ruilin , Chen Lisheng , Jing Manyi , Li Haotian , Zheng Ruimao , Zhu Yun , Zhao Yanling 
Published: April 2024

AbstractBackground and AimSmall heterodimer partner (SHP, encoded by NR0B2) plays an important role in maintaining bile acid homeostasis. The loss of the hepatic farnesoid X receptor (FXR)/SHP signal can cause severe cholestatic liver injury (CLI). FXR and SHP have overlapping and nonoverlapping functions in bile acid homeostasis. However, the key role played by SHP in CLI is unclear.MethodsIn this study, an alpha‐naphthylisothiocyanate (ANIT)‐induced cholestasis mouse model was established. The effect of SHP knockout (SHP‐KO) on liver and ileal pathology was evaluated. 16S rRNA gene sequencing analysis combined with untargeted metabolomics was applied to reveal the involvement of SHP in the pathogenesis of CLI.ResultsThe results showed that ANIT (75 mg/kg) induced cholestasis in WT mice. No significant morphological changes were found in the liver and ileal tissue of SHP‐KO mice. However, the serum metabolism and intestinal flora characteristics were significantly changed. Moreover, compared with the WT + ANIT group, the serum levels of ALT and AST in the SHP‐KO + ANIT group were significantly increased, and punctate necrosis in the liver tissue was more obvious. The ileum villi showed obvious shedding, thinning, and shortening. In addition, SHP‐KO‐associated differential intestinal flora and differential biomarkers were significantly associated.ConclusionIn this study, we elucidated the serum metabolic characteristics and intestinal flora changes related to the aggravation of CLI in SHP‐KO mice induced by ANIT.