bluuebunny/crossref_metadata_2025_split huggingface dataset:
Occurrence of esophageal carcinoma after gastrectomy
Authors: Kuwano Hiroyuki , Matsuda Hiroyuki , Nagamatsu Masaaki , Inoue Tetsuya , Ohno Shinji , Mori Masaki , Sugimachi Keizo 
Published: February 2007

AbstractA review of data on 548 patients with primary squamous cell carcinoma revealed that 24 (4.4%) had had gastrectomy. Although the interval of the gastrectomy due to peptic ulcer or gastric cancer and esophageal cancer was 13.4 ± 7.9 and 5.8 ± 4.2 years, respectively, this difference was thought to be due only to the occurrence of each disease. The incidence of the occurrence of the lower esophageal cancer after gastrectomy was 29.2%, not significantly higher than the 22.4% incidence of lower esophageal cancer in overall cases. Histopathological investigation of the 13 resected esophageal cancer tissues from gastrectomized patients revealed a mild esophagitis in some cases, with no significant histologic characteristics. Thus esophageal squamous cell carcinoma and previous gastrectomy may be incidentally related.
Primary choriocarcinoma of the lung: Report of a case treated with intensive multimodality therapy and review of the literature
Authors: Sridhar Kasi S. , Saldana Mario J. , Thurer Richard J. , Beattie Edward J. 
Published: February 2007

AbstractPrimary choriocarcinomas of the lung are extremely rare. Like choriocarcinomas elsewhere, they possess rapid growth ability and a high propensity to metastasize. There is minimal information available on the treatment of lung choriocarcinoma. In the case reported herein, neoadjuvant chemotherapy with 5‐fluorouracil (5‐FU) infusion, etoposide, and cisplatin induced a partial response permitting complete excision of a massive tumor of the right upper lobe involving the chest wall and superior vena cava. The patient relapsed with a metastasis to the brain that was surgically excised. Contralateral lung metastases were soon noted and responded well to systemic chemotherapy; yet the patient died of a new brain metastasis. To our knowledge, this is the first example of a primary choriocarcinoma of the lung treated with intensive multimodality therapy. The latter seems to offer a potential benefit if certain guidelines are followed.
Isolated soluble fractions from spleen cell culture supernatants induce tumor enhancement
Authors: Eiján Ana María , Jasnis Mariaa Adela , Motta Alicia Beatriz , Oisgold‐Dagá Sara 
Published: February 2007

AbstractSupernatants of spleen cell culture from small‐tumor‐bearing mice, large‐ tumor‐bearing mice, and large‐tumor resected mice were fractionated by Sephadex G‐100. The biological activity on tumor growth of all fractions was tested in vivo. It was found that only one fraction (MW: 220‐250 kD) from spleen cell supernatants of small‐tumor‐bearing mice or large‐tumor resected mice enhanced tumor growth. In spleen cell supernatants from large‐tumor‐bearing mice, two fractions had enhancing activity (MW: 220‐250 and 100‐10 kD). Thus, the surgical resection of large tumor induced disappearance of enhancing activity from the fraction of lower molecular weight.
Plasma cell granuloma of the adrenal gland and the thyroid: Report of two cases
Authors: De Mascarel Antoine , Vergier Béatrice , Merlio Jean‐Philippe , Goussot Jean François , Coindre Jean‐Michel 
Published: February 2007

AbstractThe clinicopathologic features of two rare cases of plasma cell granuloma of the endocrine glands are described and compared with extrapulmonary cases reported in the literature. One was localized in the adrenal gland and was revealed by amenorrhea and a large inflammatory syndrome; it is the first case reported to our knowledge. The other case developed in the thyroid, was asymptomatic, and represents the third case in the literature.
Esophageal metastasis from breast carcinoma associated with pseudoepitheliomatous hyperplasia: An unusual endoscopic diagnosis
Authors: Haim Nissim , Krugliak Pavel , Cohen Yoram , Schwartzman Zvi , Benharroch Daniel 
Published: February 2007

AbstractThe clinicopathologic findings in a patient who developed dysphagia and obstruction of the middle third of the esophagus 12 years after mastectomy for breast carcinoma are presented. Endoscopic biopsy revealed metastatic breast carcinoma with pseudoepitheliomatous hyperplasia of the overlying esophageal mucosa. To the best of our knowledge, the case represents the first reported association between esophageal metastasis and pseudoepitheliomatous hyperplasia of the esophageal squamous epithelium.
Correlation of DNA ploidy and clinical outcome in borrmann type 4 gastric carcinoma
Authors: Yonemura Yutaka , Sugiyama Kazuo , Fujimura Takashi , Kamata Toru , Kosaka Takeo , Fushida Sachio , Yamaguchi Akio , Miwa Koichi , Miyazaki Itsuo 
Published: February 2007

AbstractThe correlation between DNA ploidy pattern and clinical outcome was studied in 76 patients with Borrmann type 4 gastric carcinomas. Twenty‐six tumors were diploid, and 50 tumors were aneuploid. There was no correlation among DNA ploidy and histologic type, lymph‐node status, wall invasion, or clinical stage. The incidence of vascular invasion in the aneuploid tumors was significantly higher than that in the diploid tumors. Five year survival was achieved in 28% of the patients with diploid tumors and 8% of those with aneuploid tumors, respectively. Among the patients undergoing curative resection, 5 year survival rate was 54% in the patients with diploid tumors compared to 28% with aneuploid tumors. There was a significant survival advantage in patients with diploid tumors. These results indicate that DNA ploidy might be an important prognostic factor in Borrmann type 4 gastric carcinomas.
Hyperthermic liver toxicity: A role for oxidative stress
Authors: Skibba Joseph L. , Stadnicka Anna , Kalbfleisch John H. 
Published: February 2007

AbstractRat livers were perfused at 37°C, 41°C, 42°C, 42.5°C, and 43°C for 2 hr. Among perfusate constituents analyzed were urea, total amino acids, N‐acetyl‐β‐glucosaminidase (NAG), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), malonaldehyde (MDA), glutathione (GSH), oxidized glutathione (GSSG), allantoin, potassium, phosphate, and glucose. After perfusion, livers were homogenized and analyzed for xanthine oxidase (XO) activity, GSH content, and lysosomal lability. Perfusate AST, LDH, NAG, potassium, glucose, and phosphate increased significantly with time, and there were significant differences in the final values between 37°C and 42°C, 42.5°C, and 43°C (P < .05). GSH levels increased significantly at all temperatures after 90 and 120 min, whereas GSSG levels differed significantly at 60, 90, and 120 min for 37°C vs. 42°C, 42.5°C, and 43°C (P < .05). Mean MDA levels at 37°C differed from those at 41°C and 43°C (P < .05) at each temperature. Allantoin levels increased significantly with time of perfusion; mean levels at 37°C were significantly different from mean levels at each temperature at 60,90, and 120 min. GSH liver tissue levels decreased with perfusion at hyperthermic temperatures; mean values at 41°C, 42°C, 42.5°C, and 43°C differed from 37°C mean values (P < .01). Type O XO increased after 120 min perfusion from 6.4% ± 2.0% at 37°C to 55% ± 30%, 43% ± 27%, and 63% ± 29% at 42°C, 42.5°C, and 43°C, respectively. Lysosomal lability increased after perfusion at 42.5°C. There was a significant increase in nonsedimentable NAG activity at 42.5°C (P < .05). These data support the premise that hyperthermic toxicity to the liver may be a consequence of oxidative stress brought about by enhanced adenosine triphosphate (ATP) consumption and conversion of XO to type O. Such conversion results in superoxide formation and subsequent depletion of cellular GSH, labilization of the lysosomes, and plasma membrane damage.
Diagnostic value of cervical lymph node biopsy: A pathological study of 596 cases
Authors: Amr Samir S. , Kamal Mohammad F. , Tarawneh Musleh S. 
Published: February 2007

AbstractDuring a 10‐year period (1976‐1985), a total of 596 cervical lymph node biopsies for diagnostic purposes were performed at our institution. Thirty‐five percent of these nodes were involved with malignant lymphoma, and 20.5% showed metastatic deposits. Nondiagnostic reactive hyperplastic changes were noted in 23% of the cases. Several other inflammatory and neoplastic conditions were encountered. Comparison of our data with several series from different countries with review of relevant literature are presented.
Inflammatory pseudotumor of the liver
Authors: Li Guo‐Hui , Li Jiin‐Qing , Lin Yi‐Zhong 
Published: February 2007

AbstractSince the first report of inflammatory pseudotumor of the liver in 1953, 12 cases have been reported in the literature. The authors report herein five cases of inflammatory pseudotumor of the liver in our hospital. These tumors were resected and the diagnosis confirmed pathologically. Three of the patients were male and two female. Four of these patients had been misdiagnosed as having primary liver cancer by sonography and CT scan. Our experience has shown that if the patient had a long clinical course, few clinical symptoms, good general condition, and a negative alphafetoprotein assay, if the tumor was well encapsulated and the liver presented without cirrhosis, the patients should be suspected of having inflammatory pseudotumor of liver. In this series, all five patients underwent hepatectomy. There were no complications after operation. Surgical resection should be considered as the main therapeutic method for inflammatory pseudotumor of liver. If the patient proves unsuitable for surgical treatment, steroid therapy should be the treatment of choice. In this paper 12 cases of inflammatory pseudotumor of liver reported in the literature are reviewed and discussed.
Cystadenocarcinoma of the pancreas: Neo‐adjuvant therapy and CEA monitoring
Authors: Wood Dennis , Silberman Allan W. , Heifetz Laurence , Memsic Leslie , Shabot M. Michael 
Published: February 2007

AbstractCystadenocarcinoma of the pancreas is generally considered to be unresponsive to chemotherapy and radiation therapy. We present two cases of laparotomy‐proven unresectable cystadenocarcinoma which responded to intravenous 5‐fluorouracil (1,000 mg/m2/24 hr × 5 days × 2) and 4,000 rads of radiation therapy. Both patients had objective response with marked shrinkage of the tumor as determined by clinical examination and computed tomography. At reexploration both tumors had become completely resectable with histologically clear margins and negative lymph nodes. Carcinoembryonic antigen (CEA) levels were elevated in both patients at initial presentation (86 and 71 ng/ml). The CEA levels declined to 19.9 and 66.0 ng/ml, respectively, after neo‐adjuvant therapy, and both fell to normal levels after resection. Although surgical resection has been considered the only curative therapy for patients with pancreatic cystadenocarcinoma, we suggest that preoperative irradiation and chemotherapy may reduce the size of seemingly unresectable tumors. We also recommend serial CEA determinations in patients with levels initially elevated as a marker of the response to neo‐adjuvant and operative therapy.
Immunohistochemical analysis of the relationship between CEA localization and mononuclear cell infiltration in human colorectal carcinoma
Authors: Tanaka Kanji , Nagura Hiroshi , Hamada Yoshinori , Yamamura Manabu , Hioki Koshirou , Watanabe Keiichi , Yamamoto Masakatsu 
Published: February 2007

AbstractThirty cases of colorectal adenocarcinoma were immunohistochemicaliy examined to clarify the relationship between the degree of differentiation of cancer cells reflected by the mode of CEA localization and the infiltration pattern of mononuclear cells in the carcinoma tissues. Leu 1+, Leu 2a+, Leu 3a + 3b+ T lymphocytes, Leu 7+ cells, and IgA‐containing plasma cells tended to be distributed more in areas where CEA was localized over the entire surface of the cancer cells or in their surrounding stroma than where CEA was located along the apical surface or within the cytoplasm. Carcinoma cells with the pattern of CEA staining at the former site were previously shown to be less differentiated than those at the latter. There were also CEA‐containing phagocytes which were often observed where T cells and IgA plasma cells had aggregated. We speculated that the dedifferentiation of cancer cells might cause the host immune response, especially the cellular immunity, in malignant lesions.
Angiosarcoma of the breast with report of unusual site of first metastasis
Authors: Baum Janet K. , Levine Allan J. , Ingold John A. 
Published: February 2007

AbstractAngiosarcoma of the breast accounts for less than 1% of all primary breast lesions. It occurs at all ages, but more frequently in younger women than does primary breast carcinoma. It often has a rapidly progressive clinical course and, as in one of the reported cases, can present with unusual sites of metastases even after a long disease‐free interval.
Enhanced killing of human small cell lung cancer by hyperthermia and lndium‐111‐ bleomycin complex
Authors: Hou De‐Yan , Maruyama And Yosh 
Published: February 2007

AbstractIndium‐111‐bleomycin complex (111 In‐BLMC) is a radiopharmaceutical agent that produces tumor regression in mouse glioma in vivo and kills human small cell lung cancer (SCLC) cells in vitro. The interaction between hyperthermia and 111In‐BLMC against human SCLC (N417) cells was studied for bleomycin (BLM) (15 μ/ml) or 111In‐BLMC (40–50 μCi carried by 15 μg BLM/ml) for 5 min or 1.5, 2, or 4 hr at 37°C or 43°C exposures. Cell survival was determined by colony formation in soft aga‐rose. There was a synergistic effect for 111In‐BLMC and hyperthermia for cell killing. At 37°C, the percent survival of N417 cells for BLM alone was 25.9%, and for 111In‐BLMC it was 13.2%; at 43°C, survival was 5.3% for BLM alone and 1.2% for 111In‐BLMC by a 4 hr treatment. Effectiveness was greater when 111In‐BLMC was combined with hyperthermia.
Sodium‐24 studies in postmastectomy lymphedema
Authors: Scanlon Edward F. , Milland Francisco De P. , Hellman Leon 
Published: February 2007

AbstractSeven patients were studied with 24Na to determine the relative disappearance time of the isotope from the postmastectomy lymphedematous arm as compared to the normal side. The results tend to confirm previously held convictions that the edema is usually confined to the subcutaneous fat and skin. The disappearance time (T1/2) of the radioactive sodium from the muscle of the edematous side was usually comparable to that of the control side. The data also indicate that the impairment of fluid drainage from other areas, such as the lateral chest wall, that normally drain into the axilla, is impaired similarly to that of the subcutaneous fat of the arm. Operative procedures designed to relieve the edema of the arm by providing an alternate route of drainage should provide a conduit for the fluid to an area that does not normally drain to the axilla of the affected side.
Malignant fibrous histiocytoma of bone
Authors: Kumar Rekha V. , Mukherjee Geetashree , Bhargava M. Krishna 
Published: February 2007

AbstractMalignant fibrous histiocytoma (MFH) of bone is a malignant primary bone tumour that is being increasingly recognised, as more details emerge in the literature regarding its natural history and precise (although sometimes diverse) histological appearance. When the whole bulk of a malignant bone tumour fits the criteria laid down, the designation of MFH seems appropriate. Seven cases of MFH of bone were encountered from a total of 220 primary malignant bone tumours in our files over a 4‐year period. The metaphyses of long bones were the most common sites harbouring the tumour, and a wide age range was represented. Amputation was the treatment of choice in all cases. The relevant literature is reviewed.
Cecal carcinoma: A different colon malignancy?
Authors: Leenen Loek P. H. , Wobbes Theo , Hoekstra Harold J. , Werken Chris Van Der 
Published: February 2007

AbstractCecal carcinoma has been associated with a poorer prognosis than other colon carcinomas because of the presumed longstanding obscure symptoms. In a combined study of three Dutch hospitals, a total of 166 patients with cecal carcinoma were evaluated after right hemicolectomy. Special emphasis was placed on clinical symptoms related to advanced tumor growth, e.g., pain, anemia, and palpable mass. These factors and clinicopathological staging were evaluated with aid of the Cox regression model. Ninety percent of the resected specimens contained a Dukes' B or C carcinoma. Only 5% were found to have widespread metastatic disease. Overall 5 year survival rate was found to be 0.57. No statistically significant relation to pain or palpable mass was found. Anemia, however, was related to a better survival, especially in patients with a Dukes' B carcinoma. Clinicopathological staging according to Dukes' is closely related to survival. It is concluded that carcinoma of the cecum behaves similarly to other colon malignancies.
Adjuvant chemotherapy and scar irradiation in breast cancer
Authors: Içli Fikri , Dinçol Dilek , Isikman Erdoĝan , Ünal Muttalip 
Published: February 2007

AbstractTwenty‐three consecutive premenopausal patients with breast cancer who had four or more positive axillary nodes were treated with six cycles of CMFP followed by irradiation limited to the mastectomy scar (CT‐SRT). The relapse‐free survival (RFS) rate was compared with a group of 15 patients who were treated with chemotherapy alone (CT). Following an average follow‐up of 30 months, the relapse rates for the CT‐SRT and CT groups were 30.4% vs. 73.2%, respectively (P < 0.05).
Symptomatic pericardial effusion in lung cancer patients: The role of fluid cytology
Authors: Edoute Yehouda , Malberger Ehud , Kuten Abraham , Moscovitcz Marian , Ben‐Haim Shlomo A. 
Published: February 2007

AbstractDuring the years 1975‐1988, twenty lung cancer patients with symptomatic pericardial effusion were treated conservatively at our center. Echocardiography demonstrated small pericardial effusion in 2 patients, medium size effusion in 3 patients and large amount of fluid in 15 patients. Fifteen patients developed cardiac tamponade; in three of these patients, this was the presenting manifestation of lung cancer. Pericardiocentesis resulted in prompt, though temporary, symptomatic relief in all patients. Fluid cytology demonstrated suspected malignant cells in 2 patients and malignant cells in 13 patients. Based on cytology, the diagnosis of adenocarcinoma was established in six patients, small cell carcinoma in three patients, and epidermoid carcinoma in one patient. All patients were dead within 9 months from the time of diagnosis of pericardial effusion; 17 died within less than 3 months. It is concluded that pericardial effusion in lung cancer is indicative of rapid tumor progression and short survival. Fluid cytology provides an immediate and accurate means of diagnosis.
Preoperative cell‐mediated immune function and the prognosis of patients with gastric carcinoma
Authors: Akiyoshi Tsuyoshi , Koba Fumio , Arinaga Shinya , Ueo Hiroaki 
Published: February 2007

AbstractThe cell‐mediated immune function of 83 patients with gastric carcinoma was assessed preoperatively and the results were compared to that of 52 patients with benign lesions. The data were subjected to an analysis in order to evaluate their prognostic significance. The abilities to induce allogeneic cytotoxicity and to produce interleukin 2 (IL 2) in patients with stage IV carcinoma were significantly depressed, as compared to those in patients with benign lesions, whereas natural killer (NK) cell activity was not significantly impaired. There was no significant correlation among these immune functions. When the patients were stratified into two groups, those who had high (greater than the mean value in patients with benign lesions) and low (less than the same value) values of these immune reactivities, the survival of patients with high NK activity (⩾43%) was significantly better, as compared to that of patients with low cytotoxicity (< 43%). However, there was no correlation between the survival and allogeneic cytotoxicity in these patients. The high ability to produce IL 2 (⩾1.3 U/ml) correlated with the better survival in the patients, but not in the group of patients who underwent curative resection.
Small cell lung carcinoma: Clinicopathological, immunohistochemical, and ultrastructural study
Authors: Shy Shya‐Wen , Lee Wei‐Hwa , Chou Ming‐Chih , Lai Yieh‐Shyong , Tu Yen‐Chang 
Published: February 2007

AbstractSixty‐seven cases of small cell lung carcinoma (SCLA) in Tri‐Service General Hospital (TSGH) during the past 16 years were studied. For patients with extensive stage of disease, the mean survival time and 2‐year survival rate were 7.2 months and 3.1% versus 13.4 months and 16.7% for patients with limited stage. A better prognosis was obtained by treatment with a combination of intensive chemotherapy and radiotherapy. Immu‐nohistochemical studies were performed by the peroxidase‐antiperoxidase method. The positive rates in descending order were bombesin (80%), synaptophysin (74.3%), neurofilament (68.6%), neuron‐specific enolase (60%), low molecular weight cytokeratin (54.3%), high molecular weight cytokeratin (25.7%), chromogranin‐A (22.9%), adrenocorticotrophic hormone (0). Seven cases were examined and found to be ultrastructure; only 3 cases were found to contain neurosecretory granules. We emphasize that electron microscopy is not necessary as a routine diagnostic procedure, while light microscopy should be employed whenever possible; the immunohistochemical study should be considered within this context.
Enhanced immunoglobulin levels correlate with infectious complications after surgery in esophageal cancer
Authors: Saito Takao , Kuwahara Akihiko , Shimoda Katsuhiro , Kinoshita Tadahiko , Shigemitsu Yuji , Miyahara Masaki , Kobayashi Michio 
Published: February 2007

AbstractSevere septic complications account for the high mortality of patients with esophageal cancer. We examined the levels of immunoglobulins and complements together with infection‐related complications in a large number of patients. Enhancements of IgG, IgA, C3, C4, and CH50 were evident in patients with esophageal cancer and were more predominant compared to findings in cases of gastric cancer. Average levels of IgG and IgA immediately before surgery were significantly higher in esophageal cancer patients with postoperative septic complications than in those without such problems. Preoperative radiation therapy and total parenteral nutrition did not significantly alter the levels of immunoglobulins and complements. It would thus appear that the enhancement of IgG and IgA is associated with the occurrence of infectious complications following surgery for patients with esophageal cancer.
Subrenal capsule assay as a chemosensitivity test for primary esophageal squamous cell carcinoma
Authors: Sunagawa Masakatsu , Suzuki Tomoyuki , Ito Kinichi , Endo Mitsuo 
Published: February 2007

AbstractThe efficiency of the subrenal capsule assay (SRCA) was studied with fresh tissue of esophageal squamous cell carcinoma. The day‐to‐day changes in 10 carcinoma cases were evaluated for 9 days. The cancer cells continued to proliferate from the 3rd to the 7th day after the implantation and then decreased. The host reaction was recognized histologically from the 3rd or 4th day to the 9th day. However, the immune reaction did not significantly influence the evaluation of SRCA until the 7th day. The immunohistochemical staining with anti‐bromodeoxyuridine monoclonal antibody revealed the existence of cancer cells at the DNA synthesizing stage (S stage) in the graft until the 7th day. In chemosensitivity test by SRCA, 21 patients were studied, and all were evaluable. 5‐FU administration produced a response in 8/21 cases (38.1%), VDS in 8/21 (38.1%), and CDDP in 3/21 (14.3%). Used in combination, CDDP + VDS was effective in 7/18 cases (38.9%) and CDDP + BLM in 6/18 cases (33.3%).