bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diacylglycerol kinase is downregulated in the Drosophila Seizure Mutant during Spaceflight
Authors: Samson Fiona , Bhat Aadya , Sayyah Zachary , Reinsch Sigrid , Blaber Elizabeth 
Published: March 2024

Abstract
Accelerated aging in space is detrimental to long-term space missions. The environmental conditions in space (e.g., microgravity and radiation) cause harmful effects similar to those seen during aging. As the mechanistic pathways underlying accelerated aging in spaceflight are not fully understood, the identification of critical targets for promoting longevity in spaceflight remains challenging. We analyzed genomics data from the GLDS-207 project to identify potential targets related to longevity. Analysis of RNA-seq data from four Drosophila variants using the GeneLab Galaxy platform indicated that spaceflight significantly affected differential gene expression in the heads of flies, specifically in the seizure (sei) mutant, which alters the voltage gated potassium channels in the cell membrane. Spaceflight induced a significant decrease in the expression of the retinal degeneration A gene (rdgA) in mutant flies that survived the 30-day space mission. This gene encodes for the protein diacylglycerol kinase (DGK), which modulates the activation of the mechanistic target of the rapamycin (mTOR) signaling pathway, known to negatively regulate aging. Therefore, DGK may be a potential target for promoting longevity in space conditions. Further investigation of the effects of decreased rdgA expression on the lifespan of other organisms under spaceflight conditions will clarify the role of DGK in promoting longevity.
Redetection and description of the European dagger nematode Xiphinema diversicaudatum on peach (Prunus persica L.) in Canada
Authors: Akanwari Jerry , Yu Qing , Sultana Tahera 
Published: March 2024

Abstract
The study reports the detection of Xiphinema diversicaudatum in a peach field in Ontario, Canada. Comprehensive population characterization involved morphological and molecular analyses using 18S and 28S rDNA sequences. Morphological and molecular analysis demonstrated a close relationship between the Ontario population and those from Central Europe. This is the first report of X. diversicaudatum from peaches (Prunus persica) in Canada and in North America.
WWP2 protects against sepsis-induced cardiac injury through inhibiting cardiomyocyte ferroptosis
Authors: Li Zhi , Wu Boquan , Chen Jie , Ye Ning , Ma Rui , Song Chunyu , Sun Yingxian , Zhang Xingang , Sun Guozhe 
Published: March 2024

Abstract

Background and Objectives
Cardiac injury plays a critical role in contributing to the mortality associated with sepsis, a condition marked by various forms of programmed cell deaths. Previous studies hinted at the WW domain-containing E3 ubiquitin protein ligase 2 (WWP2) involving in heart failure and endothelial injury. However, the precise implications of WWP2 in sepsis-induced cardiac injury, along with the underlying mechanisms, remain enigmatic.

Methods
Sepsis induced cardiac injury were constructed by intraperitoneal injection of lipopolysaccharide. To discover the function of WWP2 during this process, we designed and performed loss/gain-of-function studies with cardiac-specific vectors and WWP2 knockout mice. Combination experiments were performed to investigate the relationship between WWP2 and downstream signaling in septic myocardium injury.

Results
The protein level of WWP2 was downregulated in cardiomyocytes during sepsis. Cardiac-specific overexpression of WWP2 protected heart from sepsis induced mitochondrial oxidative stress, programmed cell death and cardiac injury, while knockdown or knockout of WWP2 exacerbated this process. The protective potency of WWP2 was predominantly linked to its ability to suppress cardiomyocyte ferroptosis rather than apoptosis. Mechanistically, our study revealed a direct interaction between WWP2 and acyl-CoA synthetase long-chain family member 4 (FACL4), through which WWP2 facilitated the ubiquitin-dependent degradation of FACL4. Notably, we observed a notable reduction in ferroptosis and cardiac injury within WWP2 knockout mice after FACL4 knockdown during sepsis.

Conclusions
WWP2 assumes a critical role in safeguarding the heart against injury induced by sepsis via regulating FACL4 to inhibit LPS-induced cardiomyocytes ferroptosis.
Seasonal variations of arrhythmias and their impact on mortality in cancer patients with health disparities: A propensity score adjusted machine learning analysis of over 100 million hospitalizations across 3 years
Authors: Park Jong Kun , Monlezun Dominique , Kim Jin Wan , Going James , Khalaf Shaden , Honan Kevin , Ali Abdelrahman , Liu Victor , Barout Ahmad , Boone David , Safavi-Naeini Payam , Koutroumpakis Efstratios , Cilingiroglu Mehmet , Marmagkiolis Konstantinos , Iliescu Cezar , Karimzad Kaveh , Madjid Mohammad 
Published: March 2024

Abstract

Title
Seasonal Variations of Arrhythmias and Their Impact on Mortality in Cancer Patients with Health Disparities: A Propensity Score Adjusted Machine Learning Analysis of over 100 Million Hospitalizations Across 3 Years

Background
Arrhythmias are observed to increase during high influenza activity seasons (HIA, December to February) with significant clinical impact among high-risk patients, so their outcomes may be optimized through closer monitoring of these populations. It is unknown if cancer is such a risk factor.

Methods
This is a retrospective analysis of arrhythmia-related mortality and the effect of health disparities in patients with cancer during HIA and non-HIA seasons in a nationally representative database. Machine learning-augmented propensity score adjusted multivariable regression (ML-PSr) was performed using the 2016-2018 National Inpatient Sample (NIS), the United States’ largest all-payer hospitalized dataset.

Results
A number of 16,795,379 (18.48%) patients presented with arrhythmia of whom 3,214,914 (19.14%) were during HIA. In ML-PSr, HIA did not significantly increase the odds of arrhythmia for cancer patients (OR 1.01, 95%CI 0.99-1.03, p=0.37), but the odds of arrhythmia-related mortality were higher during HIA seasons (OR 1.19, 95%CI 1.12-1.27, p<0.001) compared to non-HIA seasons (OR 1.17, 95%CI 1.13-1.22, p<0.001). Primary malignancies with the highest prevalence of arrhythmias during HIA were that of the lung (19.60%), leukemia (11.49%), non-Hodgkin lymphoma (NHL) (8.24%), prostate (8.15%), and multiple myeloma (MM) (6.21%) (p<0.001). HIA increased arrhythmia-related mortality most for the following primary malignancies by year: gastrointestinal in 2016 (OR 1.15, 95%CI 1.01-1.32, p=0.039), leukemia in 2017 (OR 1.31, 95%CI 1.10-1.54, p=0.002), GI in 2018 (OR 1.14, 95%CI 1.01-1.29, p=0.029), and renal in 2018 (OR 1.54, 95%CI 1.06-2.23, p=0.025). Among patients with active cancer and arrhythmia, African Americans had significantly greater mortality than Caucasians (OR 1.13, 95%CI 1.03-1.23, p=0.013), independent of socioeconomic and clinical confounders.

Conclusion
This study suggests arrhythmia-related mortality was higher during HIA seasons compared to non-HIA seasons in cancer patients and showed notable disparities by race and worse outcomes by primary malignancy.
The Effect of Mindfulness Meditation Based on Spiritual Care with Rose Aromatherapy on Stress and Blood Pressure in Type 2 Diabetes Mellitus (DM) Patients
Authors: Hasina Siti Nur , Shodiq M. , Misutarno  , Putri Rahmadaniar Aditya , Noventi Iis , Rohmawati Riska 
Published: March 2024

Background: Uncontrolled blood sugar levels in patients with type 2 diabetes mellitus can trigger various complications, one of which is macroangiopathy, which is a complication of large blood vessels that affects changes in blood pressure. Stress is considered a psychological factor that can increase blood pressure. Stressful conditions in patients with diabetes mellitus can affect the control of blood sugar levels.

Aim: The purpose of this study was to analyze the effect of Mindfulness Meditation based on spiritual care with rose aromatherapy on stress and blood pressure in Type 2 Diabetes Mellitus (DM) sufferers.

Methods: The design of this study used Quasy Experimental design with pre test and post test with control group . The population in this study were all type 2 Diabetes Mellitus sufferers. Sampling was done by purposive sampling. The total number of respondents in this study was 102, divided into 51 intervention groups and 51 control groups. The independent variables in this study were mindfulness meditation based on care and rose aromatherapy and the dependent variables in this study were stress and blood pressure. The instrument used in this study was the DASS 42 questionnaire and measuring blood pressure with a digital spygmomanometer and stethoscope. data analysis using paired t test and independent t test. The hypothesis is accepted if the p value <0.05.

Results: statistical test on stress levels obtained a p value of 0.000 in the intervention group and obtained a p value of 0.003 in the control group. For systolic blood pressure, a p value of 0.000 was obtained in the intervention group and and p value of 0.011 was obtained in the control group. For diastolic blood pressure, a p value of 0.000 was obtained in the intervention group and a p value of 0.042 was obtained in the control group.

Conclusion: Mindfulness Meditation therapy based on Spiritual Care with Rose Aromatherapy can reduce stress and systolic and diastolic blood pressure. So this research is highly recommended for nurses in carrying out independent assignments, especially in providing nonpharmacological therapy.
Cilvēka dabiskais stāvoklis Hobsa, Loka un Ruso skatījumā
Authors:   Rīgas Stradiņa universitātes Humanitāro zinātņu katedra, Graudiņa Elīna 
Published: March 2024

Elīna Graudiņa in her article “The Natural State of Human According to Hobbes, Locke and Rousseau” examines the views and visions of Enlightenment thinkers on the position of an individual and society in relation to the State, society and each other. Hobbes describes the natural human condition as a selfish desire for self-preservation, characterised by a spirit of competition, distrust and fear. It is the development of “natural law” according to which a man is free to do whatever they like, and “the state of war of all against all” begins. In his natural state, man has both external freedom of action and internal freedom of will, and therefore a natural right to everything. A state where duties and rights are based on contract is a system in which the individual’s selfishness is overridden by his duty to himself, to his neighbour and to the state at large. John Locke argues that there is no innate knowledge in the individual and that man is born as a “blank slate”. He believed that an individual’s personality, knowledge and character are formed as a result of the influences of the world around him. All human beings are free, equal and independent by nature. Thomas Hobbes’s social contract theory was further developed and simultaneously criticized by Jean Jacque Rousseau. He describes transition from the state of nature to the state of citizenship. This transition brings about a remarkable change in man, replacing instinct with justice in their behaviour, giving their actions a moral meaning. What man loses with the social contract is their natural freedom, limited only by the forces of an individual. It must be distinguished from civil liberty, which is limited by the general will and property. Rousseau defends the thesis that man is good by nature and only society corrupts them morally. The philosopher cites a faulty education as one of the reasons for this, and therefore calls for an immediate reform of pedagogy, replacing traditional methods of education with “natural education”. The reform in question is based on precise knowledge of the nature of the child. Several centuries have passed since Hobbes’s conclusions on the selfishness of human nature, but this does not change the fact that the “natural state” of man has not really changed, emphasises Elīna Graudiņa. / Elīna Graudiņa rakstā “Cilvēka dabiskais stāvoklis T. Hobsa, Dž. Loka un Ž. Ž. Ruso skatījumā” aplūko apgaismības laika domātāju redzējumu un uzskatus par indivīda un sabiedrības stāvokli attiecībā pret valsti, sabiedrību, citam pret citu. Atslēgvārdi: Cilvēka dabiskais stāvoklis; valsts; sabiedrība; T. Hobss; Dž. Loks; Ž. Ž. Ruso; apgaismība; vara.
Farmer’s mental health and well-being: Qualitative findings on protective factors
Authors: Saju Sayujya , Reddy Shanivaram K. , Bijjal Somashekhar , Annapally Sadananda Reddy 
Published: March 2024

Objectives:
Agriculture is associated with various physical and mental health risks. There has been growing concern about the psychological hazards associated with farming including high stress levels, depression, anxiety, and increasing rates of suicide. To bolster resilience and overall survival within the farmers, it is imperative to gain a comprehensive understanding of the protective factors that contribute to mental and psychological well-being.

Materials and Methods:
The study followed an explorative research design and used purposive sampling to select samples from Chikkaballapur District in Karnataka. Nine farmers were interviewed based on inclusion and exclusion criteria. The interview schedule was prepared based on the literature review. Experts in the field did content and face validation. The transcribed data were coded using the free version of QDA Miner. The thematic analysis approach was used for data analysis,

Results:
Three broader themes and 15 sub-themes emerged: (1) Personal protective factors: feeling of autonomy, purpose in life, passion for work, problem-solving skills, positive mindset and building resilience, learning new skills, and spiritual and religious beliefs; (2) social protective factors: friends and peer group, belongingness, family, and social engagements; and (3) environmental protective factors: lifestyle and being physically active, rural environment, government/institutional support, and recognition in the society.

Conclusion:
The study successfully emerged three overarching protective factors that farmers perceived as significant for their mental health and well-being, entitled personal, social, and environmental. The study findings provide valuable insights for social work practitioners, guiding them in developing interventions and strategies to support the mental health and well-being of the farming population.
Pseudorandom Binary Generator Based on the Combination of Linear Feedback Shift Registers with Nonlinear Filtering Function
Authors: Debnath Narayan , Farías Andrés Francisco , Farías Andrés Alejandro , Garis Ana Gabriela , Riesco Daniel , Montejano Germán Antonio 
Published: March 2024

This work develops the procedure for the construction of a pseudorandom binary generator based in a structure made up of two blocks of four Linear Feedback Shift Register (LFSR) each, which have attached non-linear filtering functions, which deliver binary sequences that are combined by a block that contains the combination devices.The process includes: characteristics of the LFSR, definition of the model, choice of the different LFSR, selection of Boolean functions based on their optimal cryptographic properties, composition of the generator with the selected elements, key and the procedure to generate them, choice of tests statistics to be used and the criteria for analyzing the results, putting it into operation and carrying out the necessary randomness tests on the sequences obtained.
Factores que establecen la adaptación del Smartphone en el ámbito universitario. Percepción docente
Authors: Niño-Rodríguez Claudia Ivonne , Brosig-Rodríguez Mayra Elizabeth , Cantú-Rodríguez Jesús 
Published: March 2024

La incorporación de las tecnologías de la información y la comunicación, han evolucionado y transformado a la educación y a el sistema educativo en general, aportando flexibilidad a los procesos mediante la implementación de nuevas herramientas pedagógicas y acceso a diferentes escenarios educativos; por lo cual la presente investigación tiene como propósito analizar el perfil del docente que utiliza el Smartphone en el proceso de Enseñanza-Aprendizaje -Evaluación, para determinar los factores principales en las dimensiones de conocimiento, uso por lugar, uso por frecuencia, importancia, introducción pautada, iniciativa personal, y de formación. Se realizó un análisis descriptivo de los ítems que componen el cuestionario en lo referente al Smartphone, en la docencia e investigación, así como un análisis de consistencia mediante el alfa de Cronbach, para determinar la fiabilidad de cada dimensión y un análisis factorial confirmatorio de primer orden para comprobar la validez del constructo, a través del análisis de datos se muestra que los docentes cuentan con conocimiento de aplicaciones que les son útiles en su función, además de disposición para conocer más sobre este dispositivo aplicado a los procesos educativos; y como dificultades la interrupción en las sesiones, la expresión escrita y gasto adicional de internet.
Creatividad en el emprendimiento universitario: una perspectiva de género el caso ITSON
Authors: Valdez-Juárez Luis Enrique , Ruiz-Zamora José Alonso , Rubio-Alvarado Karla Berenice 
Published: March 2024

El presente estudio tiene como propósito analizar el efecto de las barreras para la creatividad en las habilidades creativas y en las intenciones emprendedoras de los estudiantes universitarios del Instituto Tecnológico de Sonora (ITSON) en México. Además, se analizan las diferencias significativas existentes entre el género (hombres y mujeres) de los estudiantes con respecto a las barreras para la creatividad, las habilidades creativas y las intenciones emprendedoras. Para la recolección de la información se utilizó una encuesta electrónica enviada a los participantes a través de correo electrónico con el uso de Google forms. El estudio es de corte cuantitativo fundamentado en el muestreo estratificado. La muestra del estudio es de 764 estudiantes universitarios. Para el análisis de los datos se utilizó la técnica de ecuaciones estructurales basada en la varianza con apoyo en el método de mínimos cuadrados parciales (PLS). Los resultados revelan que las habilidades creativas influyen fuertemente en las intenciones emprendedoras y que las barreras para la creatividad no han sido una limitante para el desarrollo de la creatividad y la intención hacia el emprendimiento. El estudio pone de manifiesto que el género femenino presenta mayor percepción positiva en las habilidades creativas y en las intenciones emprendedoras.
Total Factor Productivity and Economic Growth in Pakistan: A Five-Decade Overview
Authors: Omer Siddique  
Published: March 2024

This paper traces Pakistan’s TFP and GDP growth from 1972 to 2021. The analysis shows that Pakistan’s TFP and economic growth have declined over time. The sectoral—agriculture, industry, and services—trends are also not different. The TFP and GDP growth rates of the total economy and the three sectors were the highest in the 1980s. In general, whenever TFP growth has increased, Pakistan’s economic growth has also increased. The analysis further shows that whenever attempts were made to deregulate and liberalise the economy, it resulted in higher TFP growth and consequently higher GDP growth. Similarly, macroeconomic and political stability also seems to be important factors in higher TFP and GDP growth. The comparison with other countries shows that Pakistan’s TFP growth performance has been reasonable, especially when compared with India. At the same time, however, the experience of other countries shows that to achieve GDP growth above 8 percent, Pakistan needs to enhance its productivity growth to 3 percent or above.
Pelatihan Daur Ulang Limbah Organik Dapur Menjadi Eco Enzyme Bagi Ibu Rumah Tangga
Authors: Lustiyati Elisabeth Deta , Untari Jati , Rosali Wiwin , Dewi Desita 
Published: March 2024

Hasil capaian pembangunan Kabupaten Sleman terkait pengelolaan sampah sebagian besar 58,9% dilakukan dengan penanganan TPA. Pengelolaan sampah masih bergantung kepada kelompok yaitu TPS3R dan pengepul. Keluarga sebagai sumber awal sampah perlu melakukan usaha pengelolaan sampah rumah tangga secara mandiri. Salah satu metode pengolahan sampah organik yang mudah dilakukan di skala rumah tangga adalah pembuatan eco enzyme. Kegiatan pengabdian masyarakat ini bertujuan untuk meningkatkan pengetahuan dan keterampilan ibu rumah tangga kelompok BKR Padukuhan Tanjungsari untuk pengolahan sisa organik rumah tangga menjadi eco-enzyme. Intervensi dalam kegiatan ini menggunakan metode penyuluhan, praktik, pre-test dan post-test. Pelaksanaan kegiatan dilakukan pada Desember 2021 bertempat di Balai Bina Keluarga Remaja (BKR) Tanjungsari. Peserta kegiatan pelatihan ini adalah ibu rumah tangga kader BKR Tanjungsari sejumlah 17 orang. Hasil analisis data didapatkan bahwa rerata nilai tes peserta sesudah penyuluhan lebih tinggi daripada sebelum penyuluhan. Berdasarkan analisis data menggunakan uji-t tidak berpasangan (paired t-test) terdapat perbedaan yang signifikan skor rerata antara sebelum dan sesudah penyuluhan (p<0,05). Berdasarkan hasil evaluasi peserta menunjukkan bahwa seluruh kegiatan pada pengabdian ini telah dilaksanakan seluruhnya dengan baik.
PENGARUH INHALER STICK AROMATERAPI KOMBINASI PEPPERMINT DAN JAHE TERHADAP MUAL MUNTAH IBU HAMIL TRIMESTER I DI PUSKESMAS SUNGAI DURIAN KABUPATEN KUBU RAYA
Authors: Lepita Lepita Lepita 
Published: March 2024

Latar Belakang: Ibu hamil pada awal kehamilan sering mengalami mual muntah, ketidaknyamanan dalam masa kehamilan berhubungan dengan peningkatan Hormon Chorionic Gonadotropin (HCG). Salah satu penatalaksanaan mual muntah secara non farmakologi adalah dengan aromaterapi. Pada penelitian ini menggunakan inhaler stick aromaterapi kombinasi peppermint dan jahe. Tujuan: Untuk mengetahui pengaruh pemberian inhaler stick aromaterapi kombinasi peppermint dan jahe dengan komposisi yang berbeda terhadap mual muntah ibu hamil Trimester I. Metode: Penelitian ini menggunakan rancangan penelitian quasy eksperimen dengan desain two group pretest dan posttest, jumlah sampel sebanyak 46 orang menggunakan teknik non probability sampling dan menggunakan kuesioner PUQE. Hasil: Terdapat perbedaan skala mual muntah pada pemberian inhaler stick aromaterapi kombinasi peppermint 7 ml dan jahe 3 ml dengan pemberian inhaler stick aromaterapi kombinasi peppermint 3 ml dan jahe 7 ml terhadap ibu hamil trimester I, pada uji independent t-test diperoleh p-value 0,048. Kesimpulan: Inhaler stick aromaterapi kombinasi peppermint 7ml dan jahe 3ml lebih efektif terhadap penurunan mual muntah ibu hamil trimester I dibandingkan dengan kelompok inhaler stick aromaterapi kombinasi peppermint 3ml dan jahe 7ml.
Pengaruh Lingkungan Kerja dan Konflik Kerja terhadap Turnover Intention Karyawan pada PT Tayoh Sarana Sukses
Authors: Tungga Buana Irfana  , Asna Oktavi Dismarani  , Tungga Buana Diana  
Published: March 2024

This study aims to determine how much influence the work environment and work conflict have on employee turnover intention at PT. Tayoh Sarana Sukses. The population in this study were employees of PT.Tayoh Sarana Sukses. Sampling method using Sampling in this study using purposive sampling technique (sample considerations), namely the sampling unit selected based on certain considerations with the aim of obtaining a sampling unit that has characteristics. With the slovin formula technique. The sample used in this study were 92 employees. This study uses quantitative methods with multiple linear regression analysis, hypothesis testing using t test and f test with a significance level of 5%. Based on the t-test the work environment has a significant effect on turnover intention and work conflict has a significant effect on turnover intention. And based on the f test, the work environment and work conflict together have a significant effect on turnover intention.