bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of malting procedure on the isoflavonoid content of soybeans
Authors: Gasiński Alan , Mikulski Dawid , Kłosowski Grzegorz , Kawa-Rygielska Joanna 
Published: March 2024

AbstractThe goal of this study was to analyse, whether malting technique (consisting of seed hydration, germination and drying) can be used to modify concentration of various isoflavonoids in soybean seeds. Seeds of three soybean varieties were germinated by different lengths of time (from 24 to 120 h) and dried by two different methods, typically used to produce so-called ‘light’ and ‘caramel’ malts. It was determined, that malting decreases concentration of 7-O-β-D-glucosides such as daidzin, genisitin and glycitin, while at the same time increasing concentration of aglycones (daidzein, genistein and glycitein). Increasing time of the germination period increased concentration of aglycones. ‘Caramel’ type malts were characterised with higher concentration of most of the isoflavonoids (daidzin, daidzein, genistin, genistein and glycitein) than ‘light’ type malts. Results of this study suggest that soybean malts can be an interesting substrate in the production of various food products with increased aglycone content.
Prognosis and chemotherapy drug sensitivity in liver hepatocellular carcinoma through a disulfidptosis-related lncRNA signature
Authors: Chen Chao , Wang Chaoyang , Li Yi , Jiang Shanshan , Yu Ningjun , Zhou Guofeng 
Published: March 2024

AbstractDisulfidptosis, a new type of regulated cell death associated with the actin cytoskeleton, provides a new therapeutic tool for cancers. The direct relationship between disulfidptosis-related lncRNAs(DRLs) in liver hepatocellular carcinoma(HCC) remains unclear. We acquired transcriptomic data, corresponding clinical data, and tumor mutation data of HCC from the TCGA database. First of all, DRLs were determined through correlation analysis. Then, a prognostic model containing six DRLs was created by adopting univariate Cox regression, LASSO algorithm and multivariate Cox regression analysis. Based on the model, 424 HCC patients were divided into high- and low-risk groups. Next, we structured ROC curves and PCA through combining the model and clinical data. Enrichment analysis and immune infiltration analysis were adopted to further explore the relationship between the model and prognosis. In addition, we explored the relationship between the model and tumor mutation burden (TMB). There were significant differences between high- and low- risk groups, and patients in the high-risk group showed poor prognosis. Enrichment analysis suggested that metabolic progress was obviously different between the two groups. According to the analysis of immune infiltration, there were several differences in immune cells, function, and checkpoints. Patients with high-risk and high TMB demonstrated the least favorable prognosis. The two risk groups both manifested visiblly in chemotherapy drug sensitivity. To sum up, we set up a DRL-based signature and that may provide a predictable value for the prognosis and use of chemotherapy drugs for HCC patients.
Enzymatic activity of cGAS in the presence of three types of DNAs: limited cGAS stimulation by single-stranded HIV-1 SL2 DNA
Authors: Mizuguchi Mineyuki , Kyan Niko , Nishimata Suzuka , Nabeshima Yuko , Obita Takayuki 
Published: March 2024

Abstract
Cyclic GMP-AMP (cGAMP) synthase (cGAS) is activated by binding to DNA. Activated cGAS produces 2′3′-cGAMP, which subsequently binds to the adaptor protein STING (stimulator of interferon genes). This interaction triggers the cGAS/STING signaling pathway, leading to the production of type I interferons. Three types of DNA, namely double-stranded DNA longer than 40 base pairs, a 70-nucleotide single-stranded HIV-1 DNA known as SL2, and Y-form DNA with unpaired guanosine trimers (G3 Y-form DNA), induce interferon production by activating cGAS/STING signaling. However, the extent of cGAS activation by each specific DNA type remains unclear. The comparison of cGAS stimulation by various DNAs is crucial for understanding the mechanisms underlying cGAS-mediated type I interferon production in the innate immune response. Here, we revealed that cGAS produces 2′3′-cGAMP at a significantly lower rate in the presence of single-stranded SL2 DNA than in the presence of double-stranded DNA or G3 Y-form DNA. Furthermore, the guanine-to-cytosine mutations and the deletion of unpaired guanosine trimers significantly reduced the 2′3′-cGAMP production rate and the binding of cGAS to Y-form DNA. These studies will provide new insights into the cGAS-mediated DNA-sensing in immune response.
Study on detecting main ingredients of silicone rubber based on terahertz spectrum
Authors: Mei Hongwei , Li Lanxin , Yin Fanghui , Wang Liming , Farzaneh Masoud 
Published: March 2024

AbstractThe authors investigated the ingredient detection technique of silicone rubber based on the Terahertz spectrum. For this purpose, 18 diverse high‐temperature vulcanised silicone rubber (HTVSR) formulations were customised, 8 of which are used as calibration set while the rest 10 as prediction set. Based on the Beer‐Lambert Law, the partial‐least‐square (PLS) regression model and the least‐squares support‐vector machines (LS‐SVM) regression model were used to yield the relationships between the absorption spectrums and the content percentages of polydimethylsiloxane (PDMS), alumina trihydrate (ATH), and silica in HTVSR. The results showed that for the formulations tested, the prediction accuracy of all three main ingredients by the PLS regression model could be improved by changing the spectrum range from 0.2–4 to 0.5–2 THz. If the data were pre‐processed by the Savitzky–Golay smoothing method or multiplicative scatter correction method, the prediction accuracy of PDMS could be further enhanced. However, this would lead to a slight decrease in the prediction accuracy of ATH. For the LS‐SVM regression model, the radial basis function (RBF) kernel and the linear kernel were studied. It was found that the prediction accuracy of both kernels was better than that of the PLS regression model. With the LS‐SVM regression model using the RBF kernel, the correlated coefficients of PDMS and ATH in the prediction set could be up to 0.9915 and 0.9742, respectively.
FAUST
Authors: Sabatini G. , Podio L. , Codella C. , Watanabe Y. , De Simone M. , Bianchi E. , Ceccarelli C. , Chandler C. J. , Sakai N. , Svoboda B. , Testi L. , Aikawa Y. , Balucani N. , Bouvier M. , Caselli P. , Caux E. , Chahine L. , Charnley S. , Cuello N. , Dulieu F. , Evans L. , Fedele D. , Feng S. , Fontani F. , Hama T. , Hanawa T. , Herbst E. , Hirota T. , Isella A. , Jímenez-Serra I. , Johnstone D. , Lefloch B. , Le Gal R. , Loinard L. , Liu H. B. , López-Sepulcre A. , Maud L. T. , Maureira M. J. , Menard F. , Miotello A. , Moellenbrock G. , Nomura H. , Oba Y. , Ohashi S. , Okoda Y. , Oya Y. , Pineda J. , Rimola A. , Sakai T. , Segura-Cox D. , Shirley Y. , Vastel C. , Viti S. , Watanabe N. , Zhang Y. , Zhang Z. E. , Yamamoto S. 
Published: March 2024

Context. The origin of the chemical diversity observed around low-mass protostars probably resides in the earliest history of these systems.
Aims. We aim to investigate the impact of protostellar feedback on the chemistry and grain growth in the circumstellar medium of multiple stellar systems.
Methods. In the context of the ALMA Large Program FAUST, we present high-resolution (50 au) observations of CH3OH, H2CO, and SiO and continuum emission at 1.3 mm and 3 mm towards the Corona Australis star cluster.
Results. Methanol emission reveals an arc-like structure at ∼1800 au from the protostellar system IRS7B along the direction perpendicular to the major axis of the disc. The arc is located at the edge of two elongated continuum structures that define a cone emerging from IRS7B. The region inside the cone is probed by H2CO, while the eastern wall of the arc shows bright emission in SiO, a typical shock tracer. Taking into account the association with a previously detected radio jet imaged with JVLA at 6 cm, the molecular arc reveals for the first time a bow shock driven by IRS7B and a two-sided dust cavity opened by the mass-loss process. For each cavity wall, we derive an average H2 column density of ∼7 × 1021 cm−2, a mass of ∼9 × 10−3 M⊙, and a lower limit on the dust spectral index of 1.4.
Conclusions. These observations provide the first evidence of a shock and a conical dust cavity opened by the jet driven by IRS7B, with important implications for the chemical enrichment and grain growth in the envelope of Solar System analogues.
Investigating the scatter origin in CHEX-MATE galaxy cluster X-ray surface brightness profiles
Authors: Bartalucci I. ,   the CHEX-MATE collaboration
Published: March 2024

We present the statistical properties and the investigation on the origin of the scatter within the spatially resolved emission measure profiles of the CHEX–MATE sample, formed by 118 galaxy clusters selected via the SZ effect. These objects cover a wide mass, MYSZ500 = [2-15]×1014M⊙, and redshift, z=[0.02, 0.6], range. They have been observed by XMM-Newton with a dedicated program that ensures an unprecedented homogeneous and high quality data. We leveraged this exceptional data set by studying the statistical properties of the surface brightness and emission measure radial profiles. We found that there is a critical scale, R~ 0.4RYSZ500, within which the most morphologically relaxed and disturbed object profiles diverge. Above that radius these differences tend to be within 20%.
We complemented the CHEX–MATE clusters with a twin sample drawn from the The Three Hundred suite of cosmological simulations. Leveraging this sample, we were able for the first time to investigate separately the scatter due to projection effects and the one due to cluster-to-cluster differences. We found that projection effects have a smaller impact on the scatter compared to object-to-object differences across all scales. Building on this, we found that below 0.4RYSZ500, the scatter is of the order of 110% reflecting the wide plethora of gas distribution in cluster cores. The scatter is at its minimum, 0.56, in the intermediate range, [0.4-0.8]RYSZ500, despite their morphological status suggesting that clusters are close to the self-similar scenario within this radial range.
Lower Gastrointestinal Bleed in Children: Safety, Utility, and Yield of Colonoscopy: an Experience from a Large Tertiary Referral Endoscopy Center
Authors: Irtaza Mohd , Sundaram Sridhar , Gopan Amrit , Patra Biswa Ranjan , Rao Praveen Kumar , Kumar Sanjay , Kale Aditya P. , Shukla Akash 
Published: March 2024

Abstract
Objective: There is paucity of data on lower gastrointestinal bleed (LGIB) in the pediatric population. We aimed to retrospectively review the endoscopy findings in patients younger than 18 years, presenting with lower gastrointestinal (GI) bleed and undergoing colonoscopy.
Materials and Methods: Retrospective review of the endoscopy database at the department of gastroenterology at a tertiary care center from Western India was conducted between June 2017 until December 2021. Patients ≤18 years with LGIB, who underwent colonoscopy within 7 days of onset of bleed, were included in the study. Demographic details, endoscopic findings, and complications were noted.
Results: In all, 55 patients were included in study (65% males; median age: 13 years [range: 1–18 years]). The most common endoscopic findings were polyps in 26 (47.2%) patients, colitis in 15 (27.2%) patients, solitary rectal ulcer syndrome (SRUS) in 6 (11.3%) patients, and hemorrhoids in 3 (5.4%) patients. Five (9%) patients had normal colonoscopy in whom the cause remained unidentified on further evaluation. However, no repeat episode was documented on a follow-up of 30 days. The most common location of a polyp was the rectum (64%). Two patients had multiple polyps (2 each). All the patients underwent a successful polypectomy. Pathology reported juvenile polyps in 25 biopsies. Four were diagnosed as inflammatory bowel disease (IBD), while 11 had acute infective colitis. Patients with infectious colitis as compared to IBD had higher incidence of fever (55 vs. 0%) and lesser incidence of previous similar events (22 vs. 66%). Those with polyps were younger than those without polyps (9.1 vs. 14.3 years; p = 0.000). Polyps were significantly more common in boys (84%; 22/26; p = 0.014) than in girls. No complications occurred in this cohort of patients.
Conclusions: Polyps are the most common cause of LGIB in patients ≤18 years, followed by colitis. Polyps were more common in younger males.
Identification of Repurposed FDA Drugs by Targeting Sclerostin via the Wnt Pathway for Alveolar Bone Formation
Authors: Yadalam Pradeep K. , Anegundi Raghavendra V. , Ramadoss Ramya , Shrivastava Deepti , Alruwaili Awsaf Murdhi , Faheemuddin Muhammad , Srivastava Kumar Chandan 
Published: March 2024

Objective Natural wingless-related integration site (Wnt) pathway antagonist sclerostin (SOST) has attracted much attention because unusual bone illnesses characterized by the increased bone mass result from its absence of action. The Wnt ligand is prevented from attaching to the Frizzled family receptor when SOST is present. In the active destruction complex, -catenin is phosphorylated. -Catenin molecules do not enter the nucleus and are broken down by a proteasome. As a result, Wnt-responsive genes are not activated, which lowers bone formation and raises bone resorption. A humanized monoclonal antibody called romosozumab binds to and inhibits SOST with significant cardiac side effects. As a result, the current study's objective is to find and screen Food and Drug Administration (FDA) medications that target SOST.
Materials and Methods SOST's structure was retrieved from Protein Data Bank (PDB) (ID: 6l6r). Pharmacophore modeling and molecular operating environment-based virtual testing of FDA-approved medicines. Using the Desmond program, docking and molecular dynamics simulations were performed.
Results Our findings revealed medications with FDA approval (ZINC000253387843) Amphotericin B. The stability and receptor–ligand interactions are pretty substantial, as demonstrated by the findings of docking and Molecular dynamics simulations, which have a docking score of −7.3 k/mol and root mean square deviation stability at 40 nanoseconds, respectively.
Conclusion The suggested pharmacological therapy shows promise since it uses the Wnt pathway to target the primary bone formation mechanism. However, additional prospective studies are required to apply the available data to clinical practice.
Risks and Benefits of Device-Assisted Treatment of Pulmonary Embolism
Authors: Kim Sofia , Kim Michael , Kodra Arber 
Published: March 2024

AbstractPulmonary embolism (PE) is a common disease associated with significant morbidity and mortality. Despite the familiarity with this disease, the best treatment remains undefined. Traditionally, treatment of PE has involved a choice of anticoagulation, thrombolysis, or surgery. However, the debate over pharmacologic versus mechanical treatment of acute PE reared up again with the advent of user-friendly mechanical and aspiration thrombectomy technologies. This is especially true for submassive PE, which is an area for potential growth both for understanding the pathophysiology of the disease process and management. Multiple devices are available for treatment of PE. Understanding the risks and benefits of each device is paramount in the complex management of PE.
Experimental realization of near-critical-density laser wakefield acceleration: Efficient pointing 100-keV-class electron beam generation by microcapillary targets
Authors: Mori Michiaki , Barraza-Valdez Ernesto , Kotaki Hideyuki , Hayashi Yukio , Kando Masaki , Kondo Kiminori , Kawachi Tetsuya , Strickland Donna , Tajima Toshiki 
Published: March 2024

We experimentally demonstrated the generation of a pointing stable, low-divergence, low-energy electron beam driven by near-critical-density laser wakefield acceleration using a moderate low-intensity laser pulse. Electron beams with a half-beam divergence angle of ∼30 mrad were generated at laser intensities of 4 × 1016–1 × 1018 W/cm2 from a microcapillary hole. The pointing fluctuation of the electron beam was 1.8 mrad (root-mean-square) at the maximum laser intensity of 1 × 1018 W/cm2. The energies of the electron beam were up to 400 keV at 1 × 1018 W/cm2 and 50 keV even at 1 × 1016 W/cm2. We confirmed that the peak energy of the hump or cutoff energy of the electron beams was reproduced in particle-in-cell simulation. Such low divergence electron beam generation at sub-relativistic intensity (1016 to 1017 W/cm2 order) will lead to various applications of laser-driven keV-class electron beams, such as advanced radiotherapy.
Physical meaning of conditionally convergent series: the calculation of the Madelung constant
Authors: Etxebarria J 
Published: March 2024

Abstract
Conditionally convergent series are infinite series whose result depends on the order of the sum. One of the most famous examples of conditionally convergent series of interest in Physics is the calculation of Madelung’s constant α in ionic crystals. The appearance of this type of series is quite disturbing to students and often causes misunderstandings. In this work we analyze the physical meaning of the conditional convergence from a pedagogical point of view. The problem is posed using a toy model of ionic crystal in which the lattice sums can be calculated explicitly for various forms of expansion of the crystal about a central core. It is seen directly how the Coulomb series does not converge to α when there are charge accumulations on the surfaces. Therefore, it becomes clear what the appropriate strategy should be when choosing the order of summation to arrive at the correct value of α.
Parametric imaging based on horizontally normalized weight-adjustable Shannon entropy for tissue characterization
Authors: Zhang Xinyu , Li Xinze , Gu Yang , Jiao Yang , Dong Fenglin , Cui Yaoyao 
Published: March 2024

Abstract
Ultrasonic B-mode imaging provides real-time and non-invasive imaging for soft tissue diagnosis in clinical use, but its limited contrast leads to the challenge of detection accuracy. Quantitative ultrasound techniques have been proposed as a promising method for soft tissue characterization and reflecting the microstructure of lesions. This study proposed a novel entropy called horizontally normalized weight-adjustable Shannon entropy (hNWASE). An adjustable weight factor was added to this entropy, so that the entropy value can be changed and the imaging performance can be adjusted to lesions according to different positions and acoustic characteristics. The relationship between the adjustable parameter n and the imaging performance was explored. Moreover, the performance of the proposed hNWASE imaging was compared with weighted Shannon entropy (WSE) imaging, and horizontally normalized Shannon entropy (hNSE) imaging by both simulations and clinical data. hNSE imaging obtained a Matthews correlation coefficient (MCC) of 0.68 ± 0.11 in the thyroid nodule diagnostic tests, which underestimated the periphery of the nodule. WSE imaging got the largest area difference of 3.70 ± 1.4 mm2 between the ground truth and predicted area, which indicated that the delineation of the nodule boundary by the WSE was too large. hNWASE imaging got superior lesion area prediction with the MCC of 0.81 ± 0.06, F1 score of 0.81 ± 0.07, and generalized contrast-to-noise ratio of 0.98 ± 0.03. These findings suggested that hNWASE imaging could improve image quality and be a promising technique for tissue characterization.
Determination of diethylstilbestrol in environmental water based on electrochemical senser modified with vanadium based metal organic framework material composite
Authors: Zeng Wanpen , Wang Keli , Zhou Yuan , Deng Xiang , Xu Ruichao , Chen Wen 
Published: March 2024

Abstract
In this research, the MIL-47/ACET/Nafion/GCE electrochemical senser for the determination of diethylstilbestrol (DES) was prepared with vanadyl sulfate (VOSO4·nH2O) and terephthalic acid (H2BDC) as the main raw materials, compounded with acetylene black (ACET) and perfluorosulfonic acid polymer (Nafion). The compound DES belongs to the category of estrogens, and prolonged exposure to the environment can have detrimental effects on the physiological functioning of both humans and animals. Due to the strong DES enrichment performance of MIL-47(V-MOFs) with large specific surface area, in addition to the excellent conductivity and electrocatalysis of composite materials, this modified senser had good electrochemical response to DES. With differential pulse voltammetry, in optimum condition of 0.1 M NaH2PO4–Na2HPO4 at pH = 7.0, potential interval of −1.0 to 1.0 V, enrichment time of 120 s and enrichment potential of 0.2 V, there was a good linear relationship between peak current and the concentration of DES over the range of 0.1 and 50 μM, and the limit of detection was 0.008 μM. The sensor accurately detected DES in actual water samples, with recovery rates ranging from 89.21% to 105.3%. The electrochemical sensor was simple to prepare and had practical significance for the detection of DES in water. The research results of the sensor provide another alternative analytical means for the sensitive detection of DES in the environment, which is important for maintaining public health.
Harmonization of three different accelerometers to classify the 24 h activity cycle
Authors: Boudreaux Benjamin D , Frederick Ginny M , O’Connor Patrick J , Evans Ellen M , Schmidt Michael D 
Published: March 2024

Abstract
Increasing interest in measuring key components of the 24 h activity cycle (24-HAC) [sleep, sedentary behavior (SED), light physical activity (LPA), and moderate to vigorous physical activity (MVPA)] has led to a need for better methods. Single wrist-worn accelerometers and different self-report instruments can assess the 24-HAC but may not accurately classify time spent in the different components or be subject to recall errors. Objective. To overcome these limitations, the current study harmonized output from multiple complimentary research grade accelerometers and assessed the feasibility and logistical challenges of this approach. Approach. Participants (n = 108) wore an: (a) ActiGraph GT9X on the wrist, (b) activPAL3 on the thigh, and (c) ActiGraph GT3X+ on the hip for 7–10 d to capture the 24-HAC. Participant compliance with the measurement protocol was compared across devices and an algorithm was developed to harmonize data from the accelerometers. The resulting 24-HAC estimates were described within and across days. Main results. Usable data for each device was obtained from 94.3% to 96.7% of participants and 89.4% provided usable data from all three devices. Compliance with wear instructions ranged from 70.7% of days for the GT3X+ to 93.2% of days for the activPAL3. Harmonized estimates indicated that, on average, university students spent 34% of the 24 h day sleeping, 41% sedentary, 21% in LPA, and 4% in MVPA. These behaviors varied substantially by time of day and day of the week. Significance. It is feasible to use three accelerometers in combination to derive a harmonized estimate the 24-HAC. The use of multiple accelerometers can minimize gaps in 24-HAC data however, factors such as additional research costs, and higher participant and investigator burden, should also be considered.