bluuebunny/crossref_metadata_2025_split huggingface dataset:
Duodenal duplication cyst at the second part of the duodenum with congenital duodenal position anomaly completely resected by laparoscopic partial duodenectomy: a case report
Authors: Nakagawa Yoichi , Uchida Hiroo , Makita Satoshi , Tainaka Takahisa , Hinoki Akinari , Shirota Chiyoe , Sumida Wataru , Amano Hizuru , Yasui Akihiro , Kano Yoko , Maeda Takuya , Kato Daiki , Gohda Yousuke 
Published: March 2024

Abstract
Background
Duodenal duplication cysts (DDC) are rare duplications of the alimentary tract. Their treatment depends on their size and location. A radical treatment is total resection, if possible. However, partial excision, puncture, and marsupialization can be selected to prevent surgical injury to the pancreaticobiliary tract despite the risk of recurrence. There are some reports of pancreaticoduodenectomy for DDC because of the risk of recurrent symptoms and malignancy. However, this is considered excessively invasive for DDC, particularly in pediatric cases, because of its extremely low rate of malignancy and high morbidity and mortality rates. We encountered a case of DDC with a congenital duodenal position anomaly occurring in the second part of the duodenum. Taking advantage of the congenital duodenal position anomaly, the DDC was completely resected without injuring the pancreaticobiliary duct.

Case presentation
A 6-year-old boy was diagnosed with a duodenal duplication cyst with obstruction. There was a congenital duodenal position anomaly. The distal second part of the duodenum was the dorsal side of the proximal second part of the duodenum and ascended upward from the proximal second part of the duodenum. The third and fourth parts of the duodenum ran downward to the left and posterior parts of the portal vein, forming the ligament of Treitz. Complete laparoscopic resection of the duodenal duplication cyst and the second to fourth parts of the duodenum, and duodenojejunostomy with retrocolic reconstruction was performed because the duodenum was easily mobilized to the ligament of Treitz owing to the duodenal position anomaly. The duodenojejunostomy with retrocolic reconstruction achieved a more physiologically normal appearance compared to what would have been achieved with a Roux-en-Y reconstruction. The patient was discharged on postoperative day 12 without any complications.

Conclusions
The procedure used in this case might not be easily applied in all laparoscopy cases. However, it could be an option for duodenal duplication cysts with congenital duodenal position anomalies.
Relationship between fintech by Google search and bank stock return: a case study of Vietnam
Authors: Pham Tien Phat , Pavelkova Drahomira , Popesko Boris , Hoang Sinh Duc , Huynh Hoc Thai 
Published: March 2024

AbstractDue to the ongoing global debate regarding the relationship between fintech and banks, including developing countries, this study aims to investigate this relationship in the case of Vietnam, an emerging nation. The study analyzes the relationship between fintech search and bank stock returns, which are measures of fintech and banks, respectively. The time series data for fintech and bank stock returns were obtained from Google Trends and Vietstock, respectively. Exploratory factor analysis was utilized to derive the fintech variables, while the bank stock return variable was calculated using a basket of eight listed banks from 2017w46 to 2021w46. The results were estimated using the vector autoregression and Granger causality method and validated with the copula method. A key finding of this study is the presence of a simultaneous negative change and bidirectional causality between bank stock returns and fintech lending. Furthermore, several other interesting findings were discovered: (1) the causal relationship from fintech to bank stock returns is weaker compared with the opposite direction; (2) unidirectional causality exists between different types of fintech, such as influence from FinFintech to FinLending, from FinPayment to FinLending and FinWallet, from FinMoney to FinFintech, from FinWallet to FinLending, and from FinProduct to FinFintech; and (3) there is an equal occurrence of simultaneous increase or decrease between bank stock returns and certain types of fintech, specifically between BankReturn and FinPayment, BankReturn and FinLending, as well as BankReturn and FinWallet. These findings shed light on the complex relationship between fintech and banks, offering insights that contribute to our understanding of this dynamic interplay in the context of Vietnam’s emerging fintech landscape.
Multi-country case study on school health policy and its implementation in relation to COVID-19 control in Micronesia Small Islands Developing States
Authors: Shibuya Fumiko , Hattori-Uchima Margaret , Dacanay Paul , Peter Florence , Ngirmang Tarmau Terry , Dacanay Rudelyn , Takeuchi Rie , de los Reyes Calvin , Kobayashi Jun 
Published: March 2024

Abstract
Introduction
The COVID-19 pandemic caused school closures and rises in mental illness and non-communicable disease among school children worldwide. The Pacific Small Islands Developing States (SIDS) were also affected, but school health activities, which can effectively reduce negative effects of COVID-19, were not widely implemented compared to other Asia-Pacific countries. This study examined current school health implementation and related policies at national, local, and school levels in the Micronesia SIDS according to phases of COVID-19 control.

Methods
Multi-country case study targeted the Federated States of Micronesia (FSM), Republic of the Marshall Islands (RMI), and Republic of Palau (ROP). These studies focused on school health implementation periods according to the PPR (Prevention, Preparedness, and Response) concept: Phase #1: prevention/preparedness, #2: early phase response, and #3: chronic phase response/recovery phase. Data were collected through policy document reviews that identified school health policies related to COVID-19 controls in the three phases and key informant interviews (KIIs) with 44 key informants (FSM, n = 14; RMI, n = 18; ROP, n = 12) whose work related to school health. The collected data were analyzed using content analysis methods according to the conceptual framework in this study.

Results
This study identified three factors of school health implementation related to COVID-19 controls: promotion of decentralized education (FSM), implementation of COVID-19 controls in the school community (RMI), and disaster management for the protection of students including response to infectious disease (ROP). In Phase #1, no country had established a school health policy. In Phase #2, three enablers were identified in FSM and ROP, as reflected in COVID-19 controls by the education and health sectors. In Phase #3, RMI implemented COVID-19 controls in the school community. Documents on youth policy and disaster management in ROP were updated to reflect the chronic phase response and response to future public health crises.

Conclusions
A decentralized education was instrumental in immediately implementing COVID-19 control measures in schools at national and local levels for coordination between education and health sectors. Despite each county’s multi-sectoral approach to engage COVID-19 controls in schools, local government organization requires strengthening and implementation of the formulated school health policy. In preparation for the next public health crisis, school health should be promoted that is integrated into both infection control and disaster management.
Time series of chicken stool metagenomics and egg metabolomics in changing production systems: preliminary insights from a proof-of-concept
Authors: Rosch Michael E. G. , Rehner Jacqueline , Schmartz Georges P. , Manier Sascha K. , Becker Uta , Müller Rolf , Meyer Markus R. , Keller Andreas , Becker Sören L. , Keller Verena 
Published: March 2024

Abstract
Background
Different production systems of livestock animals influence various factors, including the gut microbiota.

Methods
We investigated whether changing the conditions from barns to free-range chicken farming impacts the microbiome over the course of three weeks. We compared the stool microbiota of chicken from industrial barns after introducing them either in community or separately to a free-range environment.

Results
Over the six time points, 12 taxa—mostly lactobacilli—changed significantly. As expected, the former barn chicken cohort carries more resistances to common antibiotics. These, however, remained positive over the observed period. At the end of the study, we collected eggs and compared metabolomic profiles of the egg white and yolk to profiles of eggs from commercial suppliers. Here, we observed significant differences between commercial and fresh collected eggs as well as differences between the former barn chicken and free-range chicken.

Conclusion
Our data indicate that the gut microbiota can undergo alterations over time in response to changes in production systems. These changes subsequently exert an influence on the metabolites found in the eggs. The preliminary results of our proof-of-concept study motivate larger scale observations with more individual chicken and longer observation periods.
The prediction value of lipiodol retention pattern on post-TACE CT scan for local progression of HCC after complete response
Authors: Grace Marie Nader , Mahmoud Bahaa Eldin , Abdel-Latif Asmaa Mohamed Hussein , Elkholy Shaima Fattouh , Saleh Mahmoud Mohamed 
Published: March 2024

Abstract
Background
Hepatocellular carcinoma (HCC) is classified as the sixth commonest cancer over the world and the fourth common in Egypt, representing the third leading cause of cancer-related mortality. Trans-arterial chemoembolization (TACE) is considered as one of the most effective treatment option for intermediate stage HCC. Lesions showing complete response (CR) after TACE can be classified according to their lipiodol retention pattern into complete (C-Lip, covering the entire tumor volume) or incomplete (I-Lip). The purpose of this study was to assess the prediction value of post-TACE lipiodol retention pattern on the local disease progression after complete response and thus to decide which patient should be carefully observed and considered to be incompletely treated.

Results
The study included 45 HCC lesions treated with TACE and showed complete response in the first follow-up CT performed 4–6 weeks after the procedure; 23 cases showed incomplete lipiodol retention pattern and 22 with complete lipiodol retention pattern which was carefully assessed on non-contrast CT images done 4 to 6 weeks after treatment. Follow-up CT was then performed every 3 months for at least 12 months or until local progression occurred. On the follow-up CT studies, 20 out of the 45 lesions showed persistent complete response (i.e., no local progression), while 25 of them showed local progression. Among the 25 cases with disease progression upon correlation with their lipiodol retention pattern, it was found that local progression occurred in 31.8% of tumors showed CR with complete lipiodol retention, as opposed to 78.2% of tumors showed CR with incomplete lipiodol retention with significant statistical difference and p value 0.010.

Conclusions
Lipiodol retention pattern of HCC after TACE can predict the potential tumor local outcome. Lesions with incomplete lipiodol retention are at a higher risk of local tumor progression and therefore should probably observed and can be retreated; on the other hand, tumors with complete lipiodol retention have a much lower risk of local disease tumor progression.
Antiproliferative effect of Saraca asoca methanol bark extract on triple negative breast cancer (TNBC)
Authors: Pareeth Chennattu M. , Hussan K. P. Safna , Anu Davis , Meera Nair , Mathew Deepu , Valsalan Ravishankar , Thayyil Mohamed Shahin , Thara Kannoor M. , Raghavamenon Achuthan C. , Babu Thekkekara D. 
Published: March 2024

Abstract
Background
Saraca asoca (Asoka) is reported to possess phytoestrogenic components with anticancer properties. The phytoestrogens are recognized as natural agonists for ERβ, which acts as an antagonist to ERα. Despite the absence of ERα, studies have identified ERβ in 50–80% of triple negative breast cancers (TNBC). Thus, the present study is intended to reveal the role of phytoestrogens of Asoka on TNBC. The cytotoxic effect of Asoka methanol bark extract was analyzed on different breast cancer cell lines by MTT assay. Estrogen-screen assay was employed to determine the proliferative/antiproliferative effect. Identification of phytoestrogens in Asoka was accomplished using LC-MS analysis and in silico docking studies were performed to investigate possible interactions of phytoestrogens with ERα and β.

Results
The extract of Asoka was found to be cytotoxic against TNBC cell line, MDAMB-231 with IC50 of 70.22 ± 1.89 μg/mL and towards HER+ breast cancer cell line, SKBR3 with IC50 of 98.41 ± 2.31 μg/mL, respectively. Whereas the extract did not show any cytotoxicity towards ERα cell line, MCF-7 even up to the concentration 300 μg/mL. Estrogen-screen assay emphasized an estrogenic effect of the extract on MCF-7 and an anti-estrogenic/antiproliferative effect on MDAMB-231 cells. LC–MS analysis identified phytoestrogens such as β-sitosterol, quercetin, kaempferol and others. The docking results revealed good binding efficacy of phytoestrogens with ERβ than ERα and quercetin shows more affinity with the highest docking score of − 9.220. Strikingly, it was found that the S. asoca methanol extract was preferentially cytotoxic to TNBC cells.

Conclusion
The study demonstrates selective anticancer properties of S. asoca methanol extract on TNBC, which indicates a selective impact on ER subtypes. The identification of phytoestrogens, such as β-sitosterol, quercetin and kaempferol, in the Asoka methanol bark extract provides a molecular basis for its observed effects. In silico studies further support the view that these phytoestrogens may preferentially interact with ERβ rather than ERα. Quercetin, in particular, demonstrated the highest binding efficacy with ERβ, suggesting its potential role in mediating the anticancer effects observed in TNBC cells. Further research is warranted to explore the full therapeutic potential of phytoestrogens in breast cancer treatment.
Design, synthesis, and evaluation of anxiolytic activity of 2-(4-phenylpiperazin-1-yl)-1H-benz[d]imidazole and 2-(4-phenylpiperazin-1-methyl)-1H-benz[d]imidazole derivatives
Authors: Mahajan Bhavna Sunil , Kawale Laxman A. , Nade Vandana S. , Unavane Supriya , Sajimon Lida , Kapadnis Prajakta 
Published: March 2024

Abstract
Background
In contemporary society, anxiety has become a widespread disorder leading to compromised well-being and heightened depressive states. Extensive literature reviews indicate the diverse biological effects of benzimidazole and piperazine derivatives, notably their impact on the central nervous system. This study aimed to design, molecularly dock, synthesize, and assess the anxiolytic potential of six derivatives of 2-(4-phenylpiperazin-1-yl)-1H-benz[d]imidazole and 2-(4-phenylpiperazin-1-methyl)-1H-benz[d]imidazole.

Results
In the present study, an attempt was made to synthesize benzimidazole derivatives conventionally. The benzimidazole nuclei are condensed with various substituted piperazines to obtain targeted benzimidazole–piperazine hybrids. Their anxiolytic activity is determined using the Elevated Plus Maze test and hole board test in mice. All compounds have shown good docking scores and in vivo anxiolytic activity.

Conclusion
Out of all the derivatives synthesized, compounds 5b, 5c, and 5f exhibited outstanding anxiolytic efficacy in both computational simulations and live subjects. Compound 5b demonstrated a remarkable docking score relative to the ligand, suggesting its potential as a promising candidate warranting further exploration.
The Glucocorticoid Receptor: Isoforms, Functions, and Contribution to Glucocorticoid Sensitivity
Authors: Lockett Jack , Inder Warrick J , Clifton Vicki L 
Published: March 2024

Abstract
Glucocorticoids exert pleiotropic effects on all tissues to regulate cellular and metabolic homeostasis. Synthetic forms are used therapeutically in a wide range of conditions for their anti-inflammatory benefits, at the cost of dose and duration-dependent side effects. Significant variability occurs between tissues, disease states, and individuals with regard to both the beneficial and deleterious effects. The glucocorticoid receptor (GR) is the site of action for these hormones and a vast body of work has been conducted understanding its function. Traditionally, it was thought that the anti-inflammatory benefits of glucocorticoids were mediated by transrepression of pro-inflammatory transcription factors, while the adverse metabolic effects resulted from direct transactivation. This canonical understanding of the GR function has been brought into question over the past 2 decades with advances in the resolution of scientific techniques, and the discovery of multiple isoforms of the receptor present in most tissues. Here we review the structure and function of the GR, the nature of the receptor isoforms, and the contribution of the receptor to glucocorticoid sensitivity, or resistance in health and disease.
Market Liquidity and Competition Among Designated Market Makers
Authors: Bellia Mario , Pelizzon Loriana , Subrahmanyam Marti G. , Yuferova Darya 
Published: March 2024

Do competition and incentives offered to designated market makers (DMMs) improve market liquidity? We employ data from NYSE Euronext Paris to show that exogenous changes in contract design lead to significant decreases in quoted and effective spreads. In particular, market liquidity increases the most for stocks with the largest increase in competition among DMMs. Our analysis shows that competition among DMMs is an important aspect of contract design, along with elements such as rebates and requirements. This paper was accepted by Kay Giesecke, finance. Funding: M. G. Subrahmanyam thanks the Alexander von Humboldt Foundation for generous financial support via the Anneliese Maier Award. L. Pelizzon thanks the Leibniz Institute for Financial Research SAFE for financially sponsoring this research and Italian Ministry for University and Research [MIUR–2017RSMPZZ]. This work was also supported by the Deutsche Forschungsgemeinschaft [Grant 329107530]. Supplemental Material: The Internet Appendix and data files are available at https://doi.org/10.1287/mnsc.2022.01801 .
Nano-Titanium Dioxide: Antioxidant Activity and Cytotoxicity Against Human Lung Cancer Cell Line
Authors: Blessymol B  , V. Kalaiselvi  , P. Yasotha  , S. Gopi  , S. Ramanathan  
Published: March 2024

The scope of this study is to synthesize titanium dioxide nanoparticles by chemical method and to assess their antioxidant and anticancer properties. Titanium isopropoxide was employed as a precursor in the production of the nanoparticles of titanium dioxide. The sample was analyzed using a variety of characterization techniques, including X-ray diffraction, Ultraviolet-Visible Spectroscopy, Fourier Transform Infrared Spectroscopy, Field Emission Scanning Electron Microscopy, Energy Dispersive X-ray analysis. Further, their antioxidant and anticancer activities have been investigated. The crystallite size of titanium dioxide nanoparticles was revealed by X-ray diffraction, and the functional groups were confirmed by Fourier Transform Infrared Spectroscopy. Field emission scanning electron microscopy and energy dispersive X-ray analysis reveal the structure of the nanoparticles and the presence of titanium, carbon, and oxygen molecules, respectively. The antioxidant activity indicates that as the concentration of the TiO2 nanoparticles increases, it reaches the activity of ascorbic acid (standard). The sample shows good cytotoxic effect against A549 human lung cancer cell lines.
High-efficiency reflective terahertz cross-polarization converter with broadband and wide-angle response
Authors: Yang Jun , Li Kaiwen , Zha Xiaojie , Zhang Guozhen , Xi Hongzhu , Deng Guangsheng , Li Ying , Yin Zhiping 
Published: March 2024

In this paper, a broadband terahertz metasurface dedicated to cross-polarization conversion was designed, fabricated, and assessed. The metasurface, comprising two nested double-split rings, features an inherent insensitivity to the angle of incidence. Simulations reveal that the converter achieves a >99% polarization conversion efficiency across the 90–140 GHz range. Moreover, it maintains a >90% polarization conversion ratio (PCR), even at a 50° incidence angle. The sample, featuring 50×70 arrays, was fabricated, and the relevant experimental results align closely with the simulated outcomes. The metasurface characteristics can markedly enhance the performance of cross-polarization converters operating in the terahertz range.
‘The illness isn’t the end of the road’—Patient perspectives on the initiation of and early participation in a multi-disease, community-based exercise programme
Authors: Regan-Moriarty Joanne , Hardcastle Sarah , McCallion Maire , Youell Azura , Collery Audrey , McCarren Andrew , Moyna Niall , Kehoe Brona 
Published: March 2024

Background
Exercise is the cornerstone of cardiac rehabilitation (CR). Hospital-based CR exercise programmes are a routine part of clinical care and are typically 6–12 weeks in duration. Following completion, physical activity levels of patients decline. Multi-disease, community-based exercise programmes (MCEP) are an efficient model that could play an important role in the long-term maintenance of positive health behaviours in individuals with cardiovascular disease (CVD) following their medically supervised programme.

Aim
To explore patients experiences of the initiation and early participation in a MCEP programme and the dimensions that facilitate and hinder physical activity engagement.

Methods
Individuals with established CVD who had completed hospital-based CR were referred to a MCEP. The programme consisted of twice weekly group exercise classes supervised by clinical exercise professionals. Those that completed (n = 31) an initial 10 weeks of the programme were invited to attend a focus group to discuss their experience. Focus groups were transcribed and analysed using reflexive thematic analysis.

Results
Twenty-four (63% male, 65.5±6.12yrs) patients attended one of four focus groups. The main themes identified were ‘Moving from fear to confidence’, ‘Drivers of engagement,’ and ‘Challenges to keeping it (exercise) up’.

Conclusion
Participation in a MCEP by individuals with CVD could be viewed as a double-edged sword. Whilst the programme clearly provided an important transition from the clinical to the community setting, there were signs it may breed dependency and not effectively promote independent exercise. Another novel finding was the use of social comparison that provided favourable valuations of performance and increased exercise confidence.