bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of strong static magnetic fields used in magnetic resonance imaging on insulin‐secreting cells
Authors: Sakurai Tomonori , Terashima Shingo , Miyakoshi Junji 
Published: June 2008

AbstractThe magnetic flux density of MRI for clinical diagnosis has been steadily increasing. However, there remains very little biological data regarding the effect of strong static magnetic fields (SMFs) on human health. To evaluate the effects of strong SMFs on biological systems, we cultured insulin‐secreting cells under exposure to sham and SMF conditions (3–10 T of magnetic flux density, and 0–41.7 T/m of magnetic field gradient) for 0.5 or 1 h, and analyzed insulin secretion, mRNA expression, glucose‐stimulated insulin secretion, insulin content, cell proliferation and cell number. Exposure to SMF with a high magnetic field gradient for 1 h significantly increased insulin secretion and insulin 1 mRNA expression. Exposure to SMF with a high magnetic flux density for 0.5 h significantly enhanced responsiveness to glucose stimulation. Exposure to SMF did not affect the insulin content, cell proliferation or cell number. Our results suggested that MRI systems with a higher magnetic flux density might not cause cell proliferative or functional damages on insulin‐secreting cells, and that SMF with a high magnetic field gradient might be used clinically after thorough in vivo investigations are conducted. Bioelectromagnetics 30:1–8, 2009. © 2008 Wiley‐Liss, Inc.
Age related mitochondrial degenerative disorders in humans
Authors: Reeve Amy K. , Krishnan Kim J. , Turnbull Doug M. 
Published: June 2008

AbstractDisorders caused by mitochondrial respiratory chain deficiency due to mutations in mitochondrial DNA have varied phenotypes but many involve neurological features often associated with cell loss within specific brain regions. These disorders, along with the increasing evidence of decline in mitochondrial function with ageing, have raised speculation that primary changes in mitochondria could have an important role in age‐related neurodegenerative diseases such as Parkinson's disease (PD) and Alzheimer's disease (AD). Evidence supporting a role for mitochondria in common neurodegenerative diseases comes from studies with the toxin MPP+ and familial PD, which has been shown to involve proteins such as DJ‐1 and Pink1 (both of which are predicted to have a role in mitochondrial function and oxidative stress). Mutations within the mitochondrial genome have been shown to accumulate with age and in common neurodegenerative diseases. Mitochondrial DNA haplogroups have also been shown to be associated with certain neurodegenerative conditions. This review covers the primary mitochondrial diseases but also discuss the potential role of mitochondria and mitochondrial DNA mutations in mitochondrial and neurodegenerative diseases, in particular in PD and in AD.
Indirect resolution of baclofen enantiomers from pharmaceutical dosage form by reversed‐phase liquid chromatography after derivatization with Marfey's reagent and its structural variants
Authors: Bhushan Ravi , Kumar Virender 
Published: June 2008

AbstractA high‐performance liquid chromatographic (HPLC) method was developed for chiral assay of baclofen enantiomers in pharmaceutical formulations using an indirect approach. Baclofen enantiomers were derivatized with Marfey's reagent (FDNP‐l‐Ala‐NH2) and its structural variants FDNP‐l‐Phe‐NH2, FDNP‐l‐Val‐NH2, FDNP‐l‐Leu‐NH2 and FDNP‐l‐Pro‐NH2. The resultant diastereomers were separated on RP‐TLC [triethylammonium phosphate buffer (pH 4.0, 50 mm)–acetonitrile, 50:50] and on a C18 column using a linear gradient (45 min) of acetonitrile and 0.01% aqueous trifluoroacetic acid (TFA) with UV detection at 340 nm. The differences in the retention times (ΔtR) of diastereomers due to the five chiral reagents were compared. The maximum and minimum difference in retention times between separated diastereomers was for FDNP‐l‐Leu‐NH2 and FDNP‐l‐Pro‐NH2, respectively. The effect of flow rate, acetonitrile content and TFA concentration on resolution was studied. The method was validated for linearity, repeatability, limit of detection and limit of quantification. Copyright © 2008 John Wiley & Sons, Ltd.
Effects of oral L‐arginine supplementation on blood pressure and asymmetric dimethylarginine in stress‐induced preeclamptic rats
Authors: Altun Zekiye Sultan , Uysal Sezer , Guner Gul , Yilmaz Osman , Posaci Cemal 
Published: June 2008

AbstractThis study was carried out to elucidate the role of asymmetric dimethylarginine (ADMA) and nitric oxide (NO) in preeclampsia development, and to investigate the effect of L‐arginine supplementation in rats. Preeclampsia was induced in pregnant rats using a stress model. L‐arginine was administered orally and ADMA, urinary nitrate, and protein levels were measured on the 20th day of pregnancy. Compared with the group of rats that are normally pregnant, the levels of blood pressure (BP), protein excretion, and ADMA were significantly increased in preeclampsia which returned to normal levels following the supplementation of L‐arginine. Both group of rats had similar urine nitrate levels. Arginine–ADMA–NO pathway is affected in preeclampsia. L‐arginine supplementation decreased hypertension (HT), proteinuria, and ADMA levels indicating that taking L‐arginine may be beneficial in preeclampsia treatment. Copyright © 2008 John Wiley & Sons, Ltd.
Generation of Novel Pikromycin Antibiotic Products Through Mutasynthesis
Authors: Gupta Shuchi , Lakshmanan Venkatraman , Kim Beom Seok , Fecik Robert , Reynolds Kevin A. 
Published: June 2008

AbstractThe pikromycin polyketide synthase (PKS) of S. venezuelae, which consists of one loading module and six extension modules, is responsible for the formation of the hexaketide narbonolide, a key intermediate in the biosynthesis of the antibiotic pikromycin. S. venezuelae strains in which PikAI, which houses the loading domain and first two modules of the PKS, is either absent or catalytically inactive, produce no pikromycin product. When these strains are grown in the presence of a synthetically prepared triketide product, activated as the N‐acetylcysteamine thioester, pikromycin yields are restored to as much as 11 % of that seen in the wild‐type strain. Feeding analogues of the triketide intermediate provides pikromycin analogues bearing different alkyl substituents at C13 and C14. One of these analogues, Δ15,16‐dehydropikromycin, exhibits improved antimicrobial activity relative to pikromycin.
Theoretical Exploration of the Oxidative Properties of a [(trenMe1)CuO2]+ Adduct Relevant to Copper Monooxygenase Enzymes: Insights into Competitive Dehydrogenation versus Hydroxylation Reaction Pathways
Authors: de la Lande Aurélien , Parisel Olivier , Gérard Hélène , Moliner Vicente , Reinaud Olivia 
Published: June 2008

AbstractSinglet and triplet H‐transfer reaction paths from CH and NH bonds were examined by means of DFT and spin‐flip TD‐DFT computations on the [(trenMe1)CuO2]+ adduct. The singlet energy surfaces allow its evolution towards H2O2 and an imine species. Whereas NH cleavage appears to be a radical process, CH rupture results in a carbocation intermediate stabilized by an adjacent N atom and an electrostatic interaction with the [CuIOOH] metal core. Upon injection of an additional electron, the latter species straightforwardly forms a hydroxylated product. Based on these computational results, a new mechanistic description of the reactivity of copper monooxygenases is proposed.
Observation of Contraction and Expansion in a Bis(peptide)‐Based Mechanical Molecular Actuator
Authors: Schafmeister Christian E. , Belasco Laura G. , Brown Patrick H. 
Published: June 2008

AbstractA novel, bis(peptide) based molecular actuator (1) has been synthesized. It is demonstrated to undergo contraction and expansion controlled by the addition and removal of Cu2+; this is demonstrated by the direct observation of a change in hydrodynamic properties by using sedimentation analysis and size exclusion chromatography. The molecule undergoes a large change in sedimentation coefficient, axial ratio, and size exclusion chromatography elution time when it binds copper. The demonstration of a controlled change in the mechanical properties of 1 make it a good starting point for the development of molecular devices that will harness changes in molecular shape and size to create molecular devices such as sensors or valves.
Phosphotungstic Acid as a Versatile Catalyst for the Synthesis of Fragrance Compounds by α‐Pinene Oxide Isomerization: Solvent‐Induced Chemoselectivity
Authors: da Silva Rocha Kelly A. , Hoehne Juliana L. , Gusevskaya Elena V. 
Published: June 2008

AbstractThe remarkable effect of the solvent on the catalytic performance of H3PW12O40, the strongest heteropoly acid in the Keggin series, allows direction of the transformations of α‐pinene oxide (1) to either campholenic aldehyde (2), trans‐carveol (3), trans‐sobrerol (4 a), or pinol (5). Each of these expensive fragrance compounds was obtained in good to excellent yields by using an appropriate solvent. Solvent polarity and basicity strongly affect the reaction pathways: nonpolar nonbasic solvents favor the formation of aldehyde 2; polar basic solvents favor the formation of alcohol 3; whereas in polar weakly basic solvents, the major products are compounds 4 a and 5. On the other hand, in 1,4‐dioxane, which is a nonpolar basic solvent, both aldehyde 2 and alcohol 3 are formed in comparable amounts. The use of very low catalyst loading (0.005–1 mol %) and the possibility of catalyst recovery and recycling without neutralization are significant advantages of this simple, environmentally benign, and low‐cost method. This method represents the first example of the synthesis of isomers from α‐pinene oxide, other than campholenic aldehyde, with a selectivity that is sufficient for practical usage.
Direct Observation of Mixed‐Valence and Radical Cation Dimer States of Tetrathiafulvalene in Solution at Room Temperature: Association and Dissociation of Molecular Clip Dimers Under Oxidative Control
Authors: Chiang Pinn‐Tsong , Chen Nai‐Chia , Lai Chien‐Chen , Chiu Sheng‐Hsien 
Published: June 2008

AbstractWe have observed the mixed‐valence and radical cation dimer states of a glycoluril‐based molecular clip with tetrathiafulvalene (TTF) sidewalls at low concentration (1 mM) at room temperature. This molecular clip has four consecutive anodic steps in its cyclic voltammogram, which suggests a sequential oxidation of these TTF sidewalls to generate species existing in several distinct charge states: neutral monomers, mixed‐valence dimers, radical cation dimers, and fully oxidized tetracationic monomers. The observation of characteristic NIR spectroscopic absorption bands at approximately 1650 and 830 nm in spectroelectrochemistry experiments supports the presence of intermediary mixed‐valence and radical cation dimers, respectively, during the oxidation process. The stacking of four TTF radical cations in the dimer led to the appearance of a charge‐transfer band at approximately 946 nm. Nanoelectrospray ionization mass spectrometry was used to verify the tricationic state and confirm the existence of other different charged dimers during the oxidation of the molecular clip.
Solid‐Phase Organic Tagging Resins for Labeling Biomolecules by 1,3‐Dipolar Cycloaddition: Application to the Synthesis of a Fluorescent Non‐Peptidic Vasopressin Receptor Ligand
Authors: Bonnet Dominique , Riché Stéphanie , Loison Stéphanie , Dagher Rania , Frantz Marie‐Céline , Boudier Laure , Rahmeh Rita , Mouillac Bernard , Haiech Jacques , Hibert Marcel 
Published: June 2008

AbstractTwo novel solid‐phase organic tagging (SPOrT) resins were synthesized to facilitate the labeling of peptides and small organic compounds with a fluorescent probe. Both resins were obtained from the commercially available backbone amide linker (BAL) resin. Following the solid‐phase synthesis of model compounds, a tripeptide and benzazepine, the fluorescent probe derived from Lissamine Rhodamine B was incorporated through CuI‐catalyzed 1,3‐dipolar cycloaddition. Final cleavage in acidic media enabled access to both types of molecules in good yield with high purity. The SPOrT resin was successfully applied to the preparation of the first non‐peptidic fluorescent compound with a nanomolar affinity for the human vasopressin V2 receptor (V2R) subtype. This molecule will find application in binding assays that use polarization or fluorescence resonance energy‐transfer (FRET) techniques. The SPOrT resins are also well suited for other tags and the parallel synthesis of a fluorescently tagged library for protein screening.
Factors Controlling the Alkyne Prins Cyclization: The Stability of Dihydropyranyl Cations
Authors: Miranda Pedro O. , Ramírez Miguel A. , Martín Víctor S. , Padrón Juan I. 
Published: June 2008

AbstractThe relative stability of the intermediates involved in the alkyne Prins cyclization and the competitive 2‐oxonia‐[3,3]‐sigmatropic rearrangement was studied. This rearrangement was shown to occur slowly under typical alkyne Prins cyclization conditions when the allenyl oxocarbenium ion that results from the rearrangement is similar to or higher in energy than the starting alkynyl oxocarbenium ion. The formal 2‐oxonia‐[3,3]‐sigmatropic rearrangement may be disfavored by destabilizing the resultant allenyl oxocarbenium ion or by stabilizing an intermediate dihydropyranyl cation. The trimethylsilyl group as a substituent at the alkyne and electron‐withdrawing groups (CH2Cl and CH2CN) located at the α‐position to the carbinol center are shown to be effective. DFT calculations suggest that these substituents stabilize the dihydropyranyl cations, thus leading to a more uniform reorganization of the electronic density in the ring, and do not have a direct effect on the formally positively charged carbon atom.
On the Mechano‐Chiral Effect of Vortical Flows on the Dichroic Spectra of 5‐Phenyl‐10,15,20‐tris(4‐sulfonatophenyl)porphyrin J‐Aggregates
Authors: El‐Hachemi Zoubir , Arteaga Oriol , Canillas Adolf , Crusats Joaquim , Escudero Carlos , Kuroda Reiko , Harada Takunori , Rosa Mònica , Ribó Josep M. 
Published: June 2008

AbstractPhase‐modulated ellipsometry of the J‐aggregates of the title porphyrin shows that the material gives a true CD signal. This confirms that there is a real chiral transfer by mechanical forces, mediated by shear gradient flows, from the macroscopic to the electronic transition level. Dislocations in the structure of the aggregate could justify the formation of chirality at the level of the electronic transitions once the mesophases can be sculptured by hydrodynamic gradient flows.
ChemInform Abstract: Instability of the Al42‐ “All‐Metal Aromatic” Ion and Its Implications.
Authors: Lambrecht Daniel S. , Fleig Timo , Sommerfeld Thomas 
Published: June 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Crystal Chemistry of Perovskite‐Type Hydride NaMgH3: Implications for Hydrogen Storage.
Authors: Wu Hui , Zhou Wei , Udovic Terrence J. , Rush John J. , Yildirim Taner 
Published: June 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Tantalum(IV) Iodide, TaI4: A Molecular Solid Consisting of Dimers of Dimers, Ta4I16.
Authors: Meyer Gerd , Wiglusz Rafal , Pantenburg Ingo , Mudring Anja‐Verena 
Published: June 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Well‐Ordered Crystals of TaI5. The Formation of the Ternary Iodide CsTaI6.
Authors: Habermehl Katja , Pantenburg Ingo , Held Peter , Meyer Gerd 
Published: June 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of a Multinary Nitride, Eu‐Doped CaAlSiN3, from Alloy at Low Temperatures.
Authors: Li Jinwang , Watanabe Tomoaki , Sakamoto Naonori , Wada Hiroshi , Setoyama Tohru , Yoshimura Masahiro 
Published: June 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Thermoluminescence and Kinetics of Persistent Luminescence of Vacuum‐Sintered Tb3+‐Doped and Tb3+,Ca2+‐Codoped Lu2O3 Materials.
Authors: Trojan‐Piegza Joanna , Niittykoski Janne , Hoelsae Jorma , Zych Eugeniusz 
Published: June 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Formation and Transformation of Five Different Phases in the CaSO4—H2O System: Crystal Structure of the Subhydrate β‐CaSO4×0.5H2O and Soluble Anhydrite CaSO4.
Authors: Christensen Axel Noerlund , Olesen Maja , Cerenius Yngve , Jensen Torben R. 
Published: June 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Lithium Insertion into Nanophase MgTi2O5 with Pseudo‐Brookite Structure.
Authors: Reddy M. Anji , Kishore M. Satya , Pralong V. , Caignaert V. , Varadaraju U. Venkata , Raveau B. 
Published: June 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Cs2Hg27, the Mercury‐Richest Amalgam with Close Relationship to the Bergman Phases.
Authors: Hoch Constantin , Simon Arndt 
Published: June 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Amine‐Catalyzed Cyclizations of Tethered α,β‐Unsaturated Carbonyl Compounds.
Authors: de Figueiredo Renata Marcia , Froehlich Roland , Christmann Mathias 
Published: June 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Enantioselective Catalytic Carbonyl—Ene Cyclization Reactions.
Authors: Grachan Melissa L. , Tudge Matthew T. , Jacobsen Eric N. 
Published: June 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of New Perhydroindole Derivatives and Their Evaluation in Ruthenium‐Catalyzed Hydrogen Transfer Reduction.
Authors: Liegault Benoit , Tang Xiaoping , Bruneau Christian , Renaud Jena‐Luc 
Published: June 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Cyclic Acetals as Precursors of Substituted Isochromans and Naphthoxepines.
Authors: Garcia Daniel , Foubelo Francisco , Yus Miguel 
Published: June 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Stereospecific and Stereoselective Alkyl and Silylcyclopropanation of α,β‐Unsaturated Amides.
Authors: Concellon Jose M. , Rodriguez‐Solla Humberto , Mejica Carmen , Blanco Elena G. , Garcia‐Granda Santiago , Diaz M. Rosario 
Published: June 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Clay Entrapped Nickel Nanoparticles as Efficient and Recyclable Catalysts for Hydrogenation of Olefins.
Authors: Dhakshinamoorthy Amarajothi , Pitchumani Kasi 
Published: June 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Hydrogen‐Transfer Reduction of Carbonyl Compounds Catalyzed by Nickel Nanoparticles.
Authors: Alonso Francisco , Riente Paola , Yus Miguel 
Published: June 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Intermolecular Cope‐Type Hydroamination of Alkenes and Alkynes.
Authors: Beauchemin Andre M. , Moran Joseph , Lebrun Marie‐Eve , Seguin Catherine , Dimitrijevic Elena , Zhang Lili , Gorelsky Serge I. 
Published: June 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.