bluuebunny/crossref_metadata_2025_split huggingface dataset:
Screening for Conscientiousness at Start of Residency: Early Detection of Professionalism Concerns
Authors: Haymaker Christopher M. , VanDerKolk Kristi , Rhodes Megan , Young Jeff , Graves Lisa 
Published: April 2024

Introduction: Early identification of residents who may require remediation could help prevent problems for both individual residents and their programs. Our aim in this project was to identify whether residents prone to challenges with professionalism could be identified early.
Methods: For 3 years we tracked onboarding tasks completed by residents between official match and the first day of residency to develop a tool that would help identify residents who may be at risk for problems with timely chart completion and subsequent remediation. We compared residents’ “at risk” scores with in-training exam (ITE) scores to differentiate between professionalism (task completion issues) and medical knowledge.
Results: Our at-risk tool successfully predicted timely chart completion rates and need for remediation within our residency program (Fischer’s exact P&lt;.001), but was not predictive of ITE scores.
Discussion: Using readily accessible information, we can identify residents at risk for poor task completion performance, who may benefit from extra support and development in the area of organizational skill. Early identification may increase opportunities for early intervention.
Multi-Omics Panoramic Analysis of HBV Integration, Transcriptional Regulation, and Epigenetic Modifications in PLC/PRF/5 Cell Line
Authors: Guan Guiwen , Abulaiti Abudurexiti , Chen Chia-Chen , Gu Zhiqiang , Yang Jing , Zhang Ting , Chen Xiaojie , Zhou Zhao , Lu Fengmin , Chen Xiangmei 
Published: April 2024

Background: The clearance or transcriptional silencing of
integrated HBV DNA is crucial for achieving a functional cure in
patients with chronic hepatitis B (CHB) and reducing the risk of
hepatocellular carcinoma (HCC) development. The PLC/PRF/5 cell line is
commonly used as an in vitro model for studying HBV integration. In this
study, we employed a range of multi-omics techniques to gain a panoramic
understanding of the characteristics of HBV integration in PLC/PRF/5
cells and to reveal the transcriptional regulatory mechanisms of
integrated HBV DNA.
Methods: Transcriptome long-read sequencing (ONT) was conducted
to analyze and characterize the transcriptional activity of different
HBV DNA integration sites in PLC/PRF/5 cells. Additionally, we collected
data related to epigenetic regulation, including whole-genome bisulfite
sequencing (WGBS), histone chromatin immunoprecipitation sequencing
(ChIP-seq), and assays for transposase-accessible chromatin using
sequencing (ATAC-seq), to explore the potential mechanisms involved in
the transcriptional regulation of integrated HBV DNA.
Result: Long-read RNA sequencing analysis revealed significant
transcriptional differences at various integration sites in the
PLC/PRF/5 cell line, with higher HBV DNA transcription levels at
integration sites on chr11, chr13, and the chr13/chr5 fusion chromosome
t (13:5). Combining long-read DNA and RNA sequencing results, we found
that transcription of integrated HBV DNA generally starts downstream of
the SP1, SP2, or XP promoters. ATAC-seq data confirmed that chromatin
accessibility has limited influence on the transcription of integrated
HBV DNA in the PLC/PRF/5 cell line. Analysis of whole-genome bisulfite
sequencing data showed that the methylation intensity of integrated HBV
DNA was highly negatively correlated with its transcription level
(r = -0.8929, p = 0.0123). After AzaD treatment, the
transcription level of integrated HBV DNA significantly increased,
especially for the integration chr17, which had the highest level of
methylation. Through ChIP-seq data, we observed the association between
histone modification of H3K4me3 and H3K9me3 with the transcription of
integrated HBV DNA.
The Effect of Pure Audit Firms, Nonprovision of Nonaudit Services to Audit Clients, and a Statutory Fee Schedule on Audit Quality Perceptions
Authors: Pappert Nicolas , Quick Reiner 
Published: April 2024

ABSTRACT
An ongoing debate revolves around instruments for enhancing the audit quality perceptions of financial statements users. Therefore, we investigate two measures that lack empirical evidence, but could theoretically improve perceived audit quality. These are a nonprovision of NAS (either by pure audit firms, or a nonprovision of NAS to audit clients) and a statutory fee schedule. We conduct an experiment with German bankers and nonprofessional investors. The results indicate that a nonprovision of NAS to audit and to all clients (i.e., pure audit case) increases perceived audit quality only if the audit firm sets audit fees internally. Moreover, a statutory fee schedule only increases perceptions of audit quality in the case of a simultaneous provision of audit services and NAS. Consequently, instead of full-banning NAS, an alternative approach would be to introduce a statutory fee schedule that would still permit the provision of NAS while adhering to existing caps.
JEL Classifications: M42; M48.
β-Cell Function, Incretin Effect, and Glucose Kinetics in Response to a Mixed Meal in Patients With Type 2 Diabetes Treated With Dapagliflozin Plus Saxagliptin
Authors: Daniele Giuseppe , Tura Andrea , Brocchi Alex , Saba Alessandro , Campi Beatrice , Sancho-Bornez Veronica , Dardano Angela , Del Prato Stefano 
Published: April 2024

OBJECTIVE
To explore the complementary effects of a combination of dipeptidyl peptidase 4 and sodium–glucose cotransporter 2 inhibitors added to metformin on hormonal and metabolic responses to meal ingestion.

RESEARCH DESIGN AND METHODS
Forty-five patients (age 58 ± 8 years; HbA1c 58 ± 6 mmol/mol; BMI 30.7 ± 3.2 kg/m2) with type 2 diabetes uncontrolled with metformin were evaluated at baseline and 3 and 28 days after 5 mg saxagliptin (SAXA), 10 mg dapagliflozin (DAPA), or 5 mg saxagliptin plus 10 mg dapagliflozin (SAXA+DAPA) using a mixed-meal tolerance test (MMTT) spiked with dual-tracer glucose to assess glucose metabolism, insulin secretion, and sensitivity.

RESULTS
At day 3, fasting and mean MMTT glucose levels were lower with SAXA+DAPA (−31.1 ± 1.6 and −91.5 ± 12.4 mg/dL) than with SAXA (−7.1 ± 2.1 and −53 ± 10.5 mg/dL) or DAPA (−17.0 ± 1.1 and −42.6 ± 10.0 mg/dL, respectively; P &lt; 0.001). Insulin secretion rate (SAXA+DAPA +75%; SAXA +11%; DAPA +3%) and insulin sensitivity (+2.2 ± 1.7, +0.4 ± 0.7, and +0.4 ± 0.4 mg ⋅ kg−1⋅ min−1, respectively) improved with SAXA+DAPA (P &lt; 0.007). Mean glucagon-like peptide 1 (GLP-1) was higher with SAXA+DAPA than with SAXA or DAPA. Fasting glucagon increased with DAPA and SAXA+DAPA but not with SAXA. Fasting endogenous glucose production (EGP) increased with SAXA+DAPA and DAPA. During MMTT, EGP suppression was greater (48%) with SAXA+DAPA (vs. SAXA 44%; P = 0.02 or DAPA 34%; P = 0.2). Metabolic clearance rate of glucose (MCRglu) increased more with SAXA+DAPA. At week 4, insulin secretion rate, β-cell glucose sensitivity, and insulin sensitivity had further increased in the SAXA+DAPA group (P = 0.02), with no additional changes in GLP-1, glucagon, fasting or MMTT EGP, or MCRglu.

CONCLUSIONS
SAXA+DAPA provided superior glycemic control compared with DAPA or SAXA, with improved β-cell function, insulin sensitivity, GLP-1 availability, and glucose clearance.
PURIFICATION OF KROSOK SALT (CRUDE SOLAR SALT) THROUGH RECRYSTALLIZATION METHOD WITH ADDITION OF DIFFERENT CONCENTRATIONS OF SLAKED LIME (Ca(OH2))
Authors: Spanton Perdana Ixbal , Anggraeni Dewi 
Published: April 2024

Purifying krosok salt (crude solar salt) is an essential step in the food and pharmaceutical industry to ensure product quality. One of the methods used for the purification of krosok salt in this study was recrystallization, involving the addition of slaked lime (Ca(OH)2) at various concentrations. Recrystallization entails dissolving salt crystals in water, followed by filtration to separate impurities from the clean salt solution. This purified salt solution is then heated to produce purer salt crystals. The aim of this study was to analyze the quality content of salt in the yielded pure salt. The significance of this research lies in its contribution of new knowledge regarding simple traditional salt processing methods, which can yield higher-quality salt with significant economic value. In this process, Ca(OH)2 was added at concentrations of 0.1%, 0.08%, and 0.06% to assess its effect on krosok salt purification. The research methodology employed experimental methods. The study's results indicated that the NaCl level test yielded an average value of 96.7% with a C concentration of 0.06%. The highest avera-ge value of 97.686% for the degree of whiteness was observed at a C concentration of 0.1%. Magnesium content averaged 0.07% at a C concentration of 0.06%, while calcium content averaged 0.058% at the same concentration. Keywords: Krosok salt, recrystallization, betel lime, salt quality.
Simple, inexpensive, and rapid approach to detect changes in the structure of soil free-living nematodes
Authors: Semprucci F. , Catani L. , Grassi E. , Jakubcsiková M. , Čerevková A. 
Published: April 2024

Summary
A general limitation of ecological investigations based on nematodes is related to the difficult and time-consuming taxonomic identification of species. Therefore, nematologists are investing many efforts to develop alternative approaches as proxies applicable in biomonitoring assessment. Recently, an alternative method that combines morpho-functional traits was proposed for detecting assemblage changes of marine nematodes. In view of the promising results, it was tested the same approach to document taxonomic structure changes of soil free-living and plant parasitic nematodes. Specifically, this attempt was carried out using three data sets that include studies from various European regions and different types of ecosystems: forests, grasslands and maize crops. Multivariate statistical analysis revealed that the simple combination of the four traits (i.e., buccal cavity cuticularization occurrence, amphideal fovea size and shape, morphology of the cuticle and pharynx) in a single code number perfectly mirrors the taxonomic structure trends of the nematode assemblage at genus level. Therefore, we predict that similar results can be also obtained by directly encoding nematode specimens with the selected traits and we point to new important advances if this procedure can be coupled with advanced machine learning.
Analysis of Pothole Detection Accuracy of Selected Object Detection Models Under Adverse Conditions
Authors: Frnda Jaroslav , Bandyopadhyay Srijita , Pavlicko Michal , Durica Marek , Savrasovs Mihails , Banerjee Soumen 
Published: April 2024

Abstract
Potholes detection is an essential aspect of road safety and road infrastructure maintenance. Potholes, which are typically caused by a combination of heavy traffic and weather, are depressions or holes in the road surface that can cause damage to specific parts of a vehicle. Autonomous vehicles, in particular, must be capable of detecting and avoiding them. Hitting a deep or sharp-edged pothole at high speed can lead to loss of control or even an accident. This makes pothole detection all the more important. The accuracy of pothole detection systems installed in autonomous vehicles may be significantly impaired by adverse weather and bad light conditions. Therefore, the classification accuracy of selected well-known computer vision models for pothole detection under these specific conditions has been investigated. The results were then compared with state-of-the-art methods. Our findings showed that we outperformed many of them when used under adverse weather and low light situations. This paper presents valuable insights into the precision of various computer vision models for potholes detection. It may aid in selecting the optimal model for a specific application.
Adiksi Smartphone dengan Postur Forward Head pada Siswa SMA: Studi Observasional
Authors: Putra Ketut Sutirama Cagi , Utama Anak Agung Gede Eka Septian , Winaya I Made Niko , Antari Ni Komang Ayu Juni 
Published: April 2024

Pendahuluan: Siswa SMA merupakan salah satu kelompok masyarakat yang aktif menggunakan teknologi, termasuk penggunaan smartphone. Penggunaan smartphone yang tidak terkendali dan berkelanjutan dapat mengakibatkan kondisi adiksi smartphone. Adiksi atau kecanduan smartphone adalah kondisi di mana seseorang sangat terikat pada penggunaan smartphone dan sulit untuk menghentikannya. Kondisi kecanduan ini dapat berdampak negatif, salah satunya terkait dengan keluhan postur seperti Forward Head Posture (FHP).
Metode: Penelitian ini menggunakan metode analitik observasional dengan pendekatan cross-sectional. Subjek penelitian ditentukan dengan menggunakan teknik simple random sampling. Jumlah subjek penelitian ini sebanyak 60 orang yang telah disesuaikan dengan kriteria inklusi dan eksklusi. Data penelitian yang dikumpulkan mencakup tingkat adiksi smartphone yang diukur dengan kuesioner Smartphone Addiction Scale-Short Version (SAS-SV), serta pengukuran derajat Craniovertebra Angle (CVA) untuk menentukan FHP, yang diukur menggunakan teknik fotogrametri.
Hasil: Uji hipotesis chi-square digunakan untuk menganalisis hubungan antara tingkat adiksi smartphone dan kejadian FHP pada siswa SMA Negeri 1 Semarapura. Hasil uji menunjukkan nilai p sebesar 0,025 (p < 0,05), menunjukkan adanya hubungan yang signifikan.
Simpulan: Dapat disimpulkan bahwa terdapat hubungan yang signifikan antara tingkat adiksi smartphone dan kejadian FHP pada siswa SMA Negeri 1 Semarapura.

Kata Kunci: adiksi, smartphone, forward head posture, siswa, SMA
Kelincahan Pemain Futsal dengan Latihan Ladder Drill Icky Shuffle: Studi Pre-Eksperimental
Authors: Desinta Dhaneswari Anak Agung Sagung , Parwata I Made Yoga , Wahyudi Antonius Tri , Larashati Ni Putu Dwi 
Published: April 2024

Pendahuluan: Futsal merupakan varian modifikasi dari sepak bola, dengan kelincahan sebagai komponen fisik utama yang diperlukan dalam permainan ini. Kelincahan adalah kemampuan individu untuk melakukan gerakan dengan memperlambat, mempercepat, mengubah arah, atau mengubah posisi tubuh tanpa kehilangan keseimbangan. Faktor-faktor internal seperti umur, jenis kelamin, dan Indeks Massa Tubuh (IMT), serta faktor eksternal seperti suhu dan kelembaban relatif, dapat memengaruhi kelincahan. Tujuan penelitian ini adalah untuk mengamati pengaruh latihan ladder drill icky shuffle terhadap peningkatan kelincahan pada pemain futsal di Universitas Dhyana Pura.
Metode: Penelitian ini termasuk dalam kategori pre-eksperimental dengan desain one group pre-test dan post-test. Penelitian dilaksanakan selama 4 minggu dengan melibatkan 19 sampel. Data dikumpulkan dengan mengukur kelincahan menggunakan shuttle run test.
Hasil: Hasil analisis deskriptif menunjukkan bahwa nilai kelincahan pada sampel sebelum menjalani latihan ladder drill icky shuffle adalah 20,12, berada dalam kategori kurang sekali. Setelah latihan, nilai rerata kelincahan meningkat menjadi 13,80, menandakan bahwa kelincahan berada dalam kategori baik. Uji hipotesis menggunakan Paired Sample t-test menunjukkan nilai p<0,05, menunjukkan adanya pengaruh positif dari latihan ladder drill icky shuffle terhadap peningkatan kelincahan.
Simpulan: Latihan ladder drill icky shuffle memiliki pengaruh yang signifikan terhadap peningkatan kelincahan pada pemain futsal. Oleh karena itu, latihan ini dapat dijadikan solusi untuk menjaga dan meningkatkan kelincahan.

Kata Kunci: futsal, kelincahan, ladder drill icky shuffle
Optimasi Keseimbangan Dinamis Atlet: Kombinasi Latihan Star Excursion dan Kinesiotaping pada Instabilitas Ankle
Authors: Wibawa Ari , Negara Anak Agung Gede Angga Puspa , Andayani Ni Luh Nopi 
Published: April 2024

Pendahuluan: Atlet yang intensif menggunakan ekstremitas bawah sering mengalami cedera, termasuk fungsional ankle instability. Ini dapat disebabkan oleh cedera pergelangan kaki berulang dan dapat mengganggu performa olahraga. Kelemahan ligamen sebagai penstabil pasif dapat menyebabkan rasa nyeri dan ketidakstabilan saat beraktivitas, mengurangi tonus postural, kekuatan otot, serta fungsi proprioceptive, stabilitas, dan keseimbangan. Salah satu pendekatan terapeutik yang dapat digunakan adalah kombinasi latihan star excursion balance dan kinesiotaping.
Tujuan: Penelitian ini bertujuan untuk menguji efektivitas kombinasi latihan star excursion balance dan kinesiotaping dalam meningkatkan keseimbangan dinamis pada atlet dengan fungsional ankle instability.
Metode: Penelitian ini merupakan penelitian praeksperimental dengan desain one pretest-posttest group, di mana kelompok sampel menjalani latihan star excursion balance dan kinesiotaping tiga kali seminggu selama enam minggu (total 18 sesi). Tingkat fungsional ankle instability diukur menggunakan Cumberland Ankle Instability Tool (CAIT), sedangkan keseimbangan dinamis diukur dengan Star Excursion Balance Test (SEBT).
Hasil: Hasil penelitian menunjukkan adanya perbedaan yang signifikan antara nilai pretest dan posttest pada kedua pengukuran SEBT dan CAIT, dengan nilai p <0,05.
Simpulan: Penelitian ini mendukung bahwa kombinasi latihan star excursion balance dan kinesiotaping efektif dalam meningkatkan keseimbangan dinamis pada atlet dengan fungsional ankle instability.

Kata Kunci: ankle instability, keseimbangan dinamis, atlet, kinesiotaping
HUBUNGAN DUKUNGAN KELUARGA DENGAN KECEMASAN PASIEN YANG MENJALANI HEMODIALISIS DI RS ROEMANI SEMARANG
Authors: Anggraini Merry Tiyas 
Published: April 2024

Latar belakang: Hemodialisis merupakan pengobatan pada penderita penyakit ginjal kronis stadium terminal. Terapi hemodialisis yang dilakukan secara terus menerus akan mengakibatkan adanya dampak psikologis seperti kecemasan. Salah satu faktor yang mempengaruhi kecemasan pasien hemodialisis yaitu dukungan keluarga. Oleh karena itu, diperlukannya dukungan pada pasien hemodialis yang bermanfaat sebagai strategi preventif untuk mengurangi kecemasan sehingga membuat pandangan hidup pasien menjadi luas. Penelitian ini bertujuan untuk mengetahui hubungan dukungan keluarga dengan kecemasan pasien yang menjalani hemodialisis di RS Roemani Semarang. Metode: Penelitian observasional analitik dengan pendekatan cross sectional dengan sampel yang memenuhi kriteria inklusi sebanyak 80 responden pada RS Roemani iSemarang dengan Teknik Total Sampling. Data diambil menggunakan instrumen kuesioner yang kemudian diuji dengan menggunakan rank spearman dengan bantuan software komputer. Hasil: Mayoritas responden memiliki kecemasan ringan sebesar 78,8% dan mayoritas responden memiliki dukungan keluarga baik sebesar 81,3%. Hasil uji menggunakan rank spearman didapatkan hasil p=0.001 dan nilai r = -i0,925. Kesimpulan: Terdapat hubungan yang signifikan antara dukungan keluarga dengan kecemasan pasien yang menjalani hemodialisis di RS Roemani Semarang, semakin tinggi dukungan keluarga semakin rendah tingkat kecemasan pasien dan sebaliknya.
POTENSI EKSTRAK DAUN SAMBILOTO (Andrographis paniculata) SEBAGAI LARVASIDA TERHADAP LARVA NYAMUK Aedes aegypti
Authors: Pratisthita Sukadana I Made Ananda Prajna , Sudarmaja I Made , Swastika I Kadek , Damayanti Putu Ayu Asri 
Published: April 2024

ABSTRAK
Demam berdarah dengue (DBD) merupakan suatu penyakit endemik yang tidak asing bagi masyarakat Indonesia bahkan menjadi masalah kesehatan dunia. DBD disebabkan oleh virus RNA rantai tunggal, yaitu dengue virus1 yang penyebarannya mengalami pola perubahan dari siklik menjadi tidak teratur sehingga berdampak pada peningkatan kasus DBD itu sendiri2. Pemerintah berupaya mencegah penyebaran kasus DBD dengan memutus rantai perkembangbiakan nyamuk aedes aegypti dengan menggunakan insektisida sintetik atau kimia. Namun, pencegahan menggunakan metode ini memberikan dampak buruk bagi lingkungan maupun kesehatan manusia. Oleh karena itu perlu dilakukan penelitian untuk mengkaji potensi ekstrak daun sambiloto sebagai larvasida nabati terhadap larva nyamuk aedes aegypti. Penelitian ini merupakan studi eksperimental sesungguhnya dengan rancangan randomized posttest only control group design. Populasi dalam penelitian ini adalah seluruh larva aedes aegyptiyang dikembangbiakan di Laboratorium Parasitologi Fakultas Kedokteran Universitas Udayana dengan besar sampel sebanyak 600 sampel larva yang terbagi menjadi 400 sampel kelompok uji (P1, P2, P3, dan P4) serta 200 sampel kelompok kontrol (P0 dan P5). Hasil analisis ANOVA dan chi square menunjukkan bahwa ekstrak etanol daun Sambiloto (Andrographis paniculata) aktif sebagai larvasida pada konsentrasi efektif 1,390% dengan waktu kontak 24 jam. Daun Sambiloto aktif sebagai larvasida karena mengandung senyawa golongan fenolat, alkaloid, flavonoid, dan terpenoid.

Kata kunci: Demam Berdarah Dengue, Ekstrak Sambiloto, Konsentrasi aktif
Agroecology: A Promising Path Towards the Sustainable Transition of Food Systems
Authors: Martins Ingryd Rodrigues , Pereira Fabiana de Oliveira , Coelho Roberta de Fátima Rodrigues , Sousa Romier da Paixão , Martins Luiza Helena da Silva , Joele Maria Regina Sarkis Peixoto 
Published: April 2024

Objective: Uncover the transformative potential of agroecology in shaping sustainable food systems, with a particular focus on its pivotal role in transitioning from conventional systems to sustainable practices rooted in agroecological principles.

Theoretical Framework: The current scenario presents alternatives to industrial agriculture, which prioritizes mass food production for global markets. In this context, agroecology emerges as a beacon of hope, championing short marketing circuits, fair trade, and a deep respect for local culture and the environment. The sharing of agroecological experiences, particularly in the context of family farming, offers a promising path toward agricultural systems that diverge from the traditional industrial model.

Method: The systematic review used scientific articles published between 2011 and 2023, selected from the Web of Science and ScienceDirect databases.

Results and Discussion: Agroecological production systems present themselves as a viable alternative to industrial agriculture, demonstrating that agroecological principles have the potential to promote healthier and more sustainable agri-food systems. Family farming plays a crucial role in this context, meeting the goals of agroecology.

Research Implications: It highlights the promising role of agroecology in promoting family farming by achieving sustainable food production and supporting the demand for healthier foods.

Originality/Value: This paper contributes to understanding the relationship between agroecology and agri-food systems, providing insights into agroecological practices, including sustainability in food production.