bluuebunny/crossref_metadata_2025_split huggingface dataset:
Response to Food Restriction, but Not Social Information Use, Varies Seasonally in Captive Cardueline Finches
Authors: Cornelius J M , Vernasco B J , Mori N , Watts H E 
Published: April 2024

Synopsis
Temperate winters can impose severe conditions on songbirds that threaten survival, including shorter days and often lower temperatures and food availability. One well-studied mechanism by which songbirds cope with such conditions is seasonal acclimatization of thermal metabolic traits, with strong evidence for both preparative and responsive changes in thermogenic capacity (i.e., the ability to generate heat) to low winter temperatures. However, a bird’s ability to cope with seasonal extremes or unpredictable events is likely dependent on a combination of behavioral and physiological traits that function to maintain allostatic balance. The ability to cope with reduced food availability may be an important component of organismal response to temperate winters in songbirds. Here, we compare responses to experimentally reduced food availability at different times of year in captive red crossbills (Loxia curvirostra) and pine siskins (Spinus pinus)—two species that cope with variable food resources and live in cold places—to investigate seasonal changes in the organismal response to food availability. Further, red crossbills are known to use social information to improve responses to reduced food availability, so we also examine whether the use of social information in this context varies seasonally in this species. We find that pine siskins and red crossbills lose less body mass during time-restricted feedings in late winter compared to summer, and that red crossbills further benefit from social information gathered from observing other food-restricted red crossbills in both seasons. Observed changes in body mass were only partially explained by seasonal differences in food intake. Our results demonstrate seasonal acclimation to food stress and social information use across seasons in a controlled captive environment and highlight the importance of considering diverse physiological systems (e.g., thermogenic, metabolic, digestive, etc.) to understand organismal responses to environmental challenges.
Epidemiology, aetiology and diagnosis of congenital hearing loss via hearing screening of 153 913 newborns
Authors: Yoshimura Hidekane , Okubo Takuya , Shinagawa Jun , Nishio Shin-Ya , Takumi Yutaka , Usami Shin-Ichi 
Published: April 2024

AbstractBackgroundCongenital hearing loss (HL), one of the most common paediatric chronic conditions, significantly affects speech and language development. Its early diagnosis and medical intervention can be achieved via newborn hearing screening. However, data on the prevalence and aetiology of congenital HL in infants who fail newborn hearing screening are limited.MethodsThe sample population included 153 913 infants who underwent newborn hearing screening, and the prevalence of congenital HL, defined as moderate to profound bilateral HL (BHL) or unilateral HL (UHL) (≥40 dB HL), in one prefecture of Japan was measured to minimize the loss-to-follow-up rate, a common factor affecting the screening procedure. Comprehensive aetiological investigation, including physiology, imaging, genetic tests, and congenital cytomegalovirus screening, was performed on children diagnosed with congenital HL.ResultsThe calculated prevalence of congenital HL was 1.62 per 1000 newborns (bilateral, 0.84; unilateral, 0.77). More than half of the cases with congenital bilateral or severe to profound UHL showed genetic aetiology or cochlear nerve deficiency (CND), respectively. Approximately 4% and 6% of the cases of congenital BHL and UHL were associated with congenital cytomegalovirus infection and auditory neuropathy spectrum disorder, respectively.ConclusionsThis is an epidemiological and comprehensive aetiological study of congenital HL, as determined via newborn hearing screening according to its severity and laterality, in a large-scale general population of a developed country. Our findings can serve as a reference for optimizing care and intervention options for children with HL and their families.
Carbon emission measurement of the envelope of a university teaching building in Hefei City
Authors: Gan Shenqi , Feng Jiawang , Fang Bigen , Chen Wenxiang 
Published: April 2024

Abstract
In response to the challenges posed by global warming, China has formulated dual carbon goals. In this context, the construction industry, a key carbon emitter, is vital for implementing energy-saving and emission-reducing strategies. This study zeroes in on the pivotal role of building envelope structures in carbon emissions, with a focus on a university building in Hefei. Commencing with onsite measurements to gather initial data, the study leverages simulation software to conduct an in-depth analysis. Employing orthogonal experimental design and variance analysis, it meticulously assesses the carbon emissions associated with different materials used in exterior walls, roofs and windows, considering both the material production and building operation phases. The research scrutinizes the impact of these materials on carbon emissions, with a special focus on the performance of seven distinct building retrofit schemes. Key findings of the study underscore that the type and thickness of exterior wall materials substantially influence carbon emissions during the production phase. Conversely, the choice of window materials emerges as more critical in reducing emissions during the building operation phase. The implementation of the various retrofit schemes demonstrates a tangible reduction in overall building carbon emissions. Specifically, these schemes yield a yearly reduction in carbon emissions of 2.96–3.62 tons during operation and a substantial decrease of 30.36–165.97 tons in the production phase, compared to the original structure of the case study building. These insights not only offer practical and viable strategies for the construction industry’s low-carbon development but also provide theoretical underpinnings and references for future building designs and retrofits.
National Pride, Economic Evaluation, and Public Support for Economic Sanctions: The Case of Japan’s Economic Sanctions Against South Korea
Authors: Kim Seongjo , Kim Hanna 
Published: April 2024

Abstract
This study addresses a research gap by exploring the impact of emotional factors, specifically national pride, on public support for economic sanctions, which has received relatively limited attention compared to the strategic aspects of sanctions. Our proposal posits that citizens’ national pride, acting as a symbolic motivation, particularly in the context of hostile national competition, can result in increased support for economic sanctions. Furthermore, we suggest that among individuals with strong national pride, the likelihood of supporting economic sanctions tends to rise as their economic perceptions improve. To investigate this relationship, we analyzed data from Japan Electoral Study VI, conducted during Japan’s economic sanctions against South Korea in 2019. These findings reveal that national pride significantly shapes public opinion on economic sanctions and that among individuals with strong national pride, positive perceptions of economic conditions act as a catalyst, strengthening their support for economic sanctions.
Reckoning with Colonial Legacies of Harm: Victoria’s Yoorrook Justice Commission
Authors: Bracka Jeremie M 
Published: April 2024

ABSTRACT
Australia’s colonial era is formally over. Yet the legacies of structural inequality, dispossession, exploitation and racism against Indigenous Australia remain alive and well. In 2021, Victoria established the Yoorrook Justice Commission, culminating in a formal truth-telling and treaty process. Seeking to address harm since colonization, the state process is unprecedented both nationally and abroad. This article considers the relevance of the commission to truth recovery, accountability and structural reform in Australia. To date, national efforts to deal with the colonial past have been piecemeal and relatively ineffective. The Yoorrook Justice Commission departs from previous single-issue inquiries as well as from reconciliation policies driven by white-Australian federal institutions. While the Commission is not a panacea for resolving colonial injustice, it provides an important means of relational and structural truth-telling towards more just relations and righting racial wrongs. Ultimately, the Yoorrook Justice Commission sets a valuable precedent for Australia and other postcolonial nations. Its level of Indigenous ownership, its authority as a Royal Commission and the breadth of its inquiry make it a significant transitional justice project.
The Costs of Caring: Quantifying Compassion Fatigue and Compassion Satisfaction in Burn Therapists
Authors: Yelvington Miranda L , Corson Tyler , Hu Jiale , Wood Rachel E , Reynolds Stacey 
Published: April 2024

Abstract
Recovery from a severe burn injury requires early and aggressive therapy, which is often painful and distressing to the patient. Burn therapists who guide these interventions may be prone to experiencing secondary trauma and compassion fatigue through repeated exposure to difficult situations. At the same time, therapists may gain a sense of purpose and altruism from their work, fostering compassion satisfaction. Despite being well documented in other health professions, compassion fatigue and compassion satisfaction have not been sufficiently explored among burn therapists. This study aimed to quantify and characterize burn therapists’ compassion fatigue and satisfaction using the Professional Quality of Life scale and to answer the question of what job-related factors may impact these outcomes. A total of 143 burn therapists participated in this study. Results revealed compassion fatigue subsale scores of burnout and secondary traumatic stress in the low or moderate range and compassion satisfaction scores in the moderate or high ranges for all participants. This study presents new knowledge for the field of burn care in its quantification of professional quality of life in burn therapists. While burn therapists experienced moderate-to-high levels of compassion satisfaction in their work, burnout and stress also approached moderate levels. Years of practice was a significant predictor of compassion. Although the reasons for this are not clear, it may be related to increased competence or confidence in practice and may suggest a need for different support strategies for practitioners at each stage of their burn therapy career.
Submarine cable detection using an end-to-end neural network-based magnetic data inversion
Authors: Liu Yutao , Wu Yuquan , Li Gang , Abbas Aqeel , Shi Taikun 
Published: April 2024

Abstract
To process magnetic anomaly data, appropriate parameters for field separation, denoising, and Euler deconvolution must be manually selected. The traditional workflow is inefficient and cannot fulfill the rapid detection of submarine cables due to complex processing and manual parameter tuning. This study presents an end-to-end deep learning approach for the identification and positioning of submarine cables based on magnetic anomalies. The proposed approach effectively establishes a direct mapping correlation between the magnetic field data and the position of the submarine cable. Synthetic tests suggest that our method performs better in terms of positioning accuracy than the conventional Euler method. Our results for the field data are comparable to those obtained using conventional techniques. Furthermore, the proposed method achieves an optimal solution by employing a clustering technique and selecting the solution with the maximum confidence, which avoids spurious solutions associated with traditional methods. The proposed method can directly determine the position of the submarine cables using the raw magnetic field data. Contrary to the traditional processing workflow, field separation and denoising are not necessary in this novel approach, resulting in higher processing efficiency and a simpler processing process.
Gian Giacomo Poldi Pezzoli and Florence
Authors: Giacomelli Luca 
Published: April 2024

Abstract
Gian Giacomo Poldi Pezzoli visited Florence repeatedly throughout his life, starting in childhood, when he accompanied his mother, Rosina Trivulzio (1800–1859). Drawing on a number of documented visits, such as one that took in the Italian National Exhibition of 1861 and another to the Dante celebrations of 1865, the aim of this essay is to examine Poldi Pezzoli’s relationship with the artistic environment, the collections and the important art market of Florence.
Multi-modular metabolic engineering and efflux engineering for enhanced lycopene production in recombinant Saccharomyces cerevisiae
Authors: Huang Guangxi , Li Jiarong , Lin Jingyuan , Duan Changqing , Yan Guoliang 
Published: April 2024

Abstract

Lycopene has been widely used in the food industry and medical field due to its antioxidant, anti-cancer, and anti-inflammatory properties. However, achieving efficient manufacture of lycopene using chassis cells on an industrial scale remains a major challenge. Herein, we attempted to integrate multiple metabolic engineering strategies to establish an efficient and balanced lycopene biosynthetic system in Saccharomyces cerevisiae. First, the lycopene synthesis pathway was modularized to sequentially enhance the metabolic flux of the mevalonate pathway, the acetyl-CoA supply module, and lycopene exogenous enzymatic module. The modular operation enabled the efficient conversion of acetyl-CoA to downstream pathway of lycopene synthesis, resulting in a 3.1-fold increase of lycopene yield. Second, we introduced acetate as an exogenous carbon source and utilized an acetate-repressible promoter to replace the natural ERG9 promoter. This approach not only enhanced the supply of acetyl-CoA but also concurrently diminished the flux toward the competitive ergosterol pathway. As a result, a further 42.3% increase in lycopene production was observed. Third, we optimized NADPH supply and mitigated cytotoxicity by overexpressing ABC transporters to promote lycopene efflux. The obtained strain YLY-PDR11 showed a 12.7-fold increase in extracellular lycopene level compared to the control strain. Finally, the total lycopene yield reached 343.7 mg/L, which was 4.3 times higher than that of the initial strain YLY-04. Our results demonstrate that combining multi-modular metabolic engineering with efflux engineering is an effective approach to improve the production of lycopene. This strategy can also be applied to the overproduction of other desirable isoprenoid compounds with similar synthesis and storage patterns in S. cerevisiae.

One-Sentence Summary
In this research, lycopene production in yeast was markedly enhanced by integrating a multi-modular approach, acetate signaling-based down-regulation of competitive pathways, and an efflux optimization strategy.
Limbic-predominant age-related TDP-43 encephalopathy (LATE-NC): Co-pathologies and genetic risk factors provide clues about pathogenesis
Authors: Nelson Peter T , Fardo David W , Wu Xian , Aung Khine Zin , Cykowski Matthew D , Katsumata Yuriko 
Published: April 2024

AbstractLimbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) is detectable at autopsy in more than one-third of people beyond age 85 years and is robustly associated with dementia independent of other pathologies. Although LATE-NC has a large impact on public health, there remain uncertainties about the underlying biologic mechanisms. Here, we review the literature from human studies that may shed light on pathogenetic mechanisms. It is increasingly clear that certain combinations of pathologic changes tend to coexist in aging brains. Although “pure” LATE-NC is not rare, LATE-NC often coexists in the same brains with Alzheimer disease neuropathologic change, brain arteriolosclerosis, hippocampal sclerosis of aging, and/or age-related tau astrogliopathy (ARTAG). The patterns of pathologic comorbidities provide circumstantial evidence of mechanistic interactions (“synergies”) between the pathologies, and also suggest common upstream influences. As to primary mediators of vulnerability to neuropathologic changes, genetics may play key roles. Genes associated with LATE-NC include TMEM106B, GRN, APOE, SORL1, ABCC9, and others. Although the anatomic distribution of TDP-43 pathology defines the condition, important cofactors for LATE-NC may include Tau pathology, endolysosomal pathways, and blood-brain barrier dysfunction. A review of the human phenomenology offers insights into disease-driving mechanisms, and may provide clues for diagnostic and therapeutic targets.
Are prophylactic antibiotics required for combined intracavitary and interstitial brachytherapy of gynecologic cancers?
Authors: Kumazawa Takuya , Ohkubo Yu , Mochida Keishiro , Kondo Saori , Oguchi Osamu , Yoshida Daisaku 
Published: April 2024

Abstract
The purpose of this study is to evaluate the need for prophylactic antibiotic treatment prior to combined intracavitary and interstitial (hybrid) brachytherapy for gynecologic cancer. A total of 105 gynecologic cancer patients received 405 brachytherapy sessions, including 302 sessions of intracavitary brachytherapy and 103 sessions of hybrid brachytherapy. Prophylactic antibiotics were administered before 35% of the hybrid brachytherapy sessions. The incidence of postbrachytherapy fever and the frequency of subsequent antibiotic use for infection were compared between treatment groups. Among patients treated with hybrid brachytherapy, fever ≥37.5°C occurred in 16.4% of those not receiving prophylactic antibiotics and 16.7% of those receiving prophylactic antibiotics (P &gt; 0.05). Similarly, fever ≥38.0°C occurred in 4.9% of patients not receiving prophylactic antibiotics and 2.4% of those receiving prophylactic antibiotics (P &gt; 0.05). Additional antibiotics were used to treat postbrachytherapy infections in 4.8% of the group receiving prophylactic antibiotics and 0% of those not receiving prophylactic antibiotics, again without statistically significant difference. There were also no significant differences in posttreatment fever incidence and antibiotics use for infection between intracavitary brachytherapy and hybrid brachytherapy sessions. In conclusion, the incidences of infection and fever are low following hybrid brachytherapy, so prophylactic antibiotics are generally unnecessary.
The Individuated, Messianic Servant of OG Isaiah 41–45
Authors: Martin Michael Wade 
Published: April 2024

Abstract
The study examines the servant oracles of Isaiah 41–45, which in the MT present a collectivist, national understanding of the figure, but in the OG are rendered so that the servant is individuated, both in the sense that he is granted clearly the quality of individuality, and in the sense that he is distinguished clearly from the collective nation he serves. The servant is also thereby rendered messianic, as Israel’s eschatological rule is transferred to this individual, along with God’s epithet, ‘your king’, and as intertextual references identify this figure as one and the same with the Davidic king of Isaiah 9 and 11. Thus OG Isaiah 41–45 attests the emergence of individualist interpretation of the servant well before the common era. These chapters also show the place of messianism in the Septuagint and in second century Alexandria.
Probing and imaging phospholipid dynamics in live cells
Authors: Wu Zhongsheng , Du Yongtao , Kirchhausen Tom , He Kangmin 
Published: April 2024

Abstract
Distinct phospholipid species display specific distribution patterns across cellular membranes, which are important for their structural and signaling roles and for preserving the integrity and functionality of the plasma membrane and organelles. Recent advancements in lipid biosensor technology and imaging modalities now allow for direct observation of phospholipid distribution, trafficking, and dynamics in living cells. These innovations have markedly advanced our understanding of phospholipid function and regulation at both cellular and subcellular levels. Herein, we summarize the latest developments in phospholipid biosensor design and application, emphasizing the contribution of cutting-edge imaging techniques to elucidating phospholipid dynamics and distribution with unparalleled spatiotemporal precision.
The EBLM project – XIII. The absolute dynamical masses of the circumbinary planet host TOI-1338/BEBOP-1, and applications to the study of exoplanet atmospheres
Authors: Sebastian D , Triaud A H M J , Brogi M , Baycroft Thomas A , Standing Matthew R , Maxted Pierre F L , Martin David V , Sairam Lalitha , Nielsen Martin B 
Published: April 2024

ABSTRACT
High-contrast eclipsing binaries with low mass M-dwarf secondaries are precise benchmark stars to build empirical mass–radius relationships for fully convective low-mass ($\rm M_{\star } \lt 0.35\, M_{\odot }$) dwarf stars. The contributed light of the M-dwarf in such binaries is usually much less than one per cent at optical wavelengths. This enables the detection of circumbinary planets from precise radial velocity measurements. High-resolution cross-correlation techniques are typically used to detect exoplanet atmospheres. One key aspect of these techniques is the post-processing, which includes the removal of telluric and spectral lines of the host star. We introduce the application of such techniques to optical high-resolution spectra of the circumbinary planet-host TOI-1338/BEBOP-1, turning it effectively into a double-lined eclipsing binary. By using simulations, we further explore the impact of post-processing techniques for high-contrast systems. We detect the M-dwarf secondary with a significance of 11σ and measure absolute dynamical masses for both components. Compared to previous model-dependent mass measurements, we obtain a four times better precision. We further find that the post-processing results in negligible systematic impact on the radial velocity precision for TOI-1338/BEBOP-1 with more than $96.6\,$ per cent (1σ) of the M-dwarf’s signal being conserved. We show that these methods can be used to robustly measure dynamical masses of high-contrast single-lined binaries providing important benchmark stars for stellar evolution particularly near the bottom of the main sequence. We also demonstrate how to retrieve the phase curve of an exoplanet with high-resolution spectroscopy using our data.