bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interstitial wires releasing diffusing alpha emitters combined with chemotherapy improved local tumor control and survival in squamous cell carcinoma‐bearing mice
Authors: Cooks Tomer , Arazi Lior , Efrati Margalit , Schmidt Michael , Marshak Gideon , Kelson Itzhak , Keisari Yona 
Published: February 2009

AbstractBACKGROUND:The objective of this study was to examine the combined effect of diffusing alpha‐emitter radiation therapy (DART) together with the chemotherapeutic agent cisplatin on tumor development.METHODS:BALB/c mice bearing squamous cell carcinoma tumors were treated with radium 224 (224Ra‐)–loaded stainless steel wires, releasing short‐lived, alpha‐emitting atoms from their surface. A concomitant regimen of cisplatin doses (5 mg/kg per dose) was given intravenously for the evaluation of the combined effect. Animals were monitored for tumor growth and survival.RESULTS:First, the authors observed that alpha particles and cisplatin inhibited SQ2 cell proliferation in vitro and promoted apoptosis. Treatment of tumor‐bearing mice indicated that, when a regimen of 2 separate doses of cisplatin was given concomitantly with a single intratumoral 224Ra‐loaded wire, there was moderate tumor growth inhibition relative to what was observed from each treatment alone. When tumors were treated with 2 radioactive wires positioned near the tumor base and a similar drug administration, the growth arrest effect intensified, and there also was a significant increase in survival rates. The combined treatment reduced both local tumor growth and metastatic spread to the lungs.CONCLUSIONS:Antitumor activity and overall survival of metastatic tumor‐bearing mice were improved significantly by the combined treatment. These results highlight the potential benefit of alpha radiation‐based radiotherapy in combination with chemotherapeutic drugs for anticancer treatment. Cancer 2009. © 2009 American Cancer Society.
Optical tools to assess naturalness of cosmetic films
Authors: Maitra Prithwiraj , Balina Angelina , Carlo Steven , Glynn John R. 
Published: February 2009

AbstractDeveloping technologies and cosmetic formulations that mimic the optical properties of healthy, youthful skin is a significant challenge and has been one of the recent key areas of focus in the cosmetic industry. A common tool to assess optical properties of cosmetic formulations involves use of spectrophotometer with an integrating sphere to measure transmittance and opacity. Given that the human face is three‐dimensional and contoured, and that the human eye processes information gathered at many angles, adding a measure that capture the angular behavior of light provides cosmetic scientists with an additional valuable tool. Here we describe addition of wide angle transmittance measurement via goniospectrophotometer to the optical tool kit. Results with soft focus materials and commercially available cosmetic products are reported. © 2009 Wiley Periodicals, Inc. Col Res Appl, 34, 170–172, 2009
A spectrophotometric color matching algorithm for precolored fiber blends
Authors: Li Rong , Song Yang , Gu Feng , Pan Wei 
Published: February 2009

AbstractIn this article, a spectrophotometric color matching algorithm based on Stearns‐Noechel model is proposed. This algorithm was run to predict recipes for 48 viscose blends. Color differences between the original blend samples and the calculated were expressed in CIELAB units (10°standard observer). M (the empirical constant in Stearns‐Noechel model) value was determined by median analysis. When M equals to 0.09, the best fit was obtained for three‐components fiber blends. In that case, the maximum color difference is 1.22 CIELAB units and the average computed color difference is 0.56 CIELAB units for 36 three‐components fiber blends under D65 illuminant. When M is from 0.03 to 0.06, the best fit was obtained for four‐components fiber blends. In that case, the maximum color difference is 4.48 CIELAB units and the average computed color difference is 1.02 CIELAB units for 12 four‐components fiber blends under D65 illuminant. It is demonstrated that the algorithm can be used in color matching of fiber blends. © 2009 Wiley Periodicals, Inc. Col Res Appl, 34, 108–114, 2009
Proposal for selecting two‐color combinations with various affections. Part II: Demonstration of the system
Authors: Sakai Hideki , Nayatani Yoshinobu 
Published: February 2009

AbstractThe characteristics of the proposed color selection system are shown using several colored figures of two‐color combinations selected by the system. There are four kinds of color feelings in the system, and each feeling is classified into three categories (i.e., high, intermediate, or low). The feelings used are pleasantness, contrast, floridness, and warmth. Users can try the 34 = 81 combinations of feelings by setting the categories for four kinds of feelings. The differences among categories of color feelings are also shown by several colored figures. It is difficult to describe the differences by words. However, it is rather easy to describe by pictures. The proposed color selection system is expected to be a useful tool for assisting color designers. Comments about the proposed system from potential users are reported. © 2009 Wiley Periodicals, Inc. Col Res Appl, 34, 135–140, 2009
The new deviate visual functions improving the instrumental estimation on the visual color difference for the metamers with about 1° field size
Authors: Kuo Wen‐Guey , Wei Yuh‐Chang , Liu Alex , Lin Shang‐Ming , Shu Yi‐Ting 
Published: February 2009

AbstractAlthough the CIE1931 and 1964 color matching functions have been used in color specification for decades, many researchers, from Allen in 1970 to Hu and Houser in 2006, have found that there still exists a great visual mismatch on the discrimination of color difference as in terms of the CIE color matching functions. Hence, some significant error would be made on color specification due to employing the CIE1931 and 1964 color matching functions. Therefore, six color difference formulae developed from different experimental methods are used to derive various deviate visual functions (DVFs) respectively, and to investigate the effect of these DVFs on the performance of the color difference formulae tested in estimating visual color difference. The results indicate that the performance of the color difference formulae in estimating color difference is significantly improved by the deviate visual functions derived in this study. The CIE94 color difference formula has the best performance in predicting the total visual color difference (ΔVT) using the DVFs and DVFIIs having the mean values 29 and 27 in PF/4 unit, respectively, while the CMC(l:c) the worst the ones 37 and 38. © 2009 Wiley Periodicals, Inc. Col Res Appl, 34, 115–127, 2009
Urbanization effects on watershed habitat potential: a multivariate assessment of thresholds and interactions
Authors: Randhir Timothy , Ekness Paul 
Published: February 2009

AbstractA watershed‐based assessment is used to assess the effect of urbanization on vertebrate habitat potential in Westfield River Watershed in Massachusetts, USA. A spatial analysis is used to develop urban indicators and habitat potential for each subbasin in the watershed. It is observed that threshold effect of urbanization on habitat potential of vertebrates is at 10 to 12 percent impervious cover. Amphibian habitat is influenced by available open space and land use disturbance in the watershed. The reptile habitat is sensitive to impervious coverage and land use disturbance, and decreased with fragmentation. The habitat for birds is influenced by land use disturbance, human population densities, size of forest patch, and open space in the watershed. Mammal habitat is influenced by human population density, land use disturbance, and fragmentation. A watershed‐based assessment is useful to identify critical areas of high urban influence. Threshold values and nature of interactions between urbanization and habitat are assessed and used in policy recommendations. Policies and practices that minimize effects of urbanization in the watershed include impervious taxes, zoning policies, and open space protection. The need for provision of education and information on the relationship between urbanization and habitat potential is emphasized for sustainable use of watershed resources. Copyright © 2009 John Wiley & Sons, Ltd.
Synergistic regulation of Pseudomonas aeruginosa‐induced cytokine production in human monocytes by mannose receptor and TLR2
Authors: Xaplanteri Panagiota , Lagoumintzis George , Dimitracopoulos George , Paliogianni Fotini 
Published: February 2009

AbstractThe immune response to pathogen is regulated by a combination of specific PRR, which are involved in pathogen recognition. Pseudomonas aeruginosa, a bacterium that causes life‐threatening disease in immuno‐compromised host, is recognized by distinct members of the TLR family. We have previously shown that viable P. aeruginosa bacteria are recognized by human monocytes mainly through TLR2. Using ligand‐specific blocking antibodies, we herein show that the mannose receptor (MR), a phagocytic receptor for unopsonized P. aeruginosa bacteria, contributes equally to TLR2 in proinflammatory cytokine production by human monocytes in response to P. aeruginosa infection. Synergy of both receptors totally controls the immune response. Viable P. aeruginosa bacteria activate NF‐κB and MAPK pathways and enhance TLR2‐mediated signaling in MR‐transfected human embryonic kidney 293 cells. Moreover, MR follows the same kinetics and colocalizes with TLR2 in the endosome during in vivo infection of human macrophages with P. aeruginosa. The studies provide the first demonstration of a significant role for MR, synergistic with TLR2, in activating a proinflammatory response to P. aeruginosa infection.
Kinetics of Bis(p‐nitrophenyl)phosphate (BNPP) Hydrolysis Reactions with Trivalent Lanthanide Complexes of N‐Hydroxyethyl(ethylenediamine)‐ N,N′,N′‐triacetate (HEDTA)
Authors: Chang C. Allen , Chen Yu‐Ping , Hsiao Chih‐Hsiang 
Published: February 2009

AbstractKinetic studies of hydrolysis reactions of BNPP [sodium bis(p‐nitrophenyl)phosphate] with trivalent lanthanide (Ln3+) complexes of HEDTA [HEDTA = N‐hydroxyethyl(ethylenediamine)‐N,N′,N′‐triacetate] were performed at pH 6.96–11.34 and 25 °C by a spectrophotometric method and by HPLC analysis. The reaction rates increase with increasing atomic number of lanthanide and solution pH from PrHEDTA to EuHEDTA and then decrease for heavier LnHEDTA complexes. Plots of pseudo‐first‐order rate constants (kobs) vs. pH could be fitted to the equation kobs = kLnL(OH)[LnL]T/{1 + exp[–2.303(pH – pKh)]}, where kLnL(OH) is the rate constant for the reaction of LnHEDTA(OH)– with BNPP, Kh is the hydrolysis constant of LnHEDTA, and [LnL]T is the total concentration of LnHEDTA. The pKh values obtained by the kinetic method are in the range 8.2–10.3 and are similar to those measured by potentiometric methods. At [LnL]T = 10–70 mM and pH 10.5, most of the observed pseudo‐first‐order rate constants could be fitted to a simple saturation kinetic model, kobs = k1K[LnHEDTA(OH)–]/{1 + K[LnHEDTA(OH)–]}, where K is the equilibrium constant for the formation for LnHEDTA(OH)–BNPP and is in the range 2–147 M–1. The k1 values are in the range 1.12 × 10–5–2.71 × 10–3 s–1. The kobs data for TbHEDTA and HoHEDTA were fitted to a quadratic equation. It was observed that the dinuclear species are more reactive. ESI mass spectrometry confirmed that the reaction between BNPP and EuHEDTA is a simple hydrolysis but not a transesterification, presumably because the three inner‐sphere coordinated water molecules are far away from the coordinated hydroxyethyl group. Hydrolysis is likely to occur by proton transfer from one inner‐sphere coordinated water molecule to the deprotonated ethyl oxide group followed by nucleophilic attack of the resulting hydroxide ion on the bonded BNPP anion.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Solvothermal Syntheses of Two New Thiostannates and an In‐Situ Energy Dispersive X‐ray Scattering Study of Their Formation
Authors: Pienack Nicole , Näther Christian , Bensch Wolfgang 
Published: February 2009

AbstractTwo new thiostannates, (DBNH)2Sn3S6 (1) and (DBNH)2Cu6Sn2S8 (2), were synthesized under solvothermal conditions using Cu, Sn, S and DBN (DBN = 1,5‐diazabicyclo[4.3.0]non‐7‐ene). Compound 1 is a rare example of a mixed‐valent thiostannate. The SnII center exists in the rare trigonal pyramidal coordination environment, whereas SnIV is tetrahedrally coordinated. The chain‐anion is composed of alternating Sn3S4 semi‐cubes and Sn2S2 rings. The structure of 2 consists of undulated anionic layers with amine molecules between the layers. The layers may be viewed as a heteroatom 63 graphene layer constructed of condensed CuS3 triangles and SnS4 tetrahedra. The two thiostannates coexist, and this was investigated with in‐situ energy dispersive X‐ray scattering under solvothermal conditions. Prior to the formation of 1 and 2, a crystalline intermediate appears, which disappears after 60 min. Then reflections of 2 start to grow, and reflections of 1 appear some time later. The appearance of a thiostannate(IV) species followed by the crystallization of a mixed‐valent thiostannate(II,IV) species suggests that complex redox reactions are occurring under the solvothermal conditions. Syntheses without Cu in the reaction slurry lead to the formation of 1 within a very short time period. The results of the in‐situ studies clearly indicate that the presence of Cu species in solution retards the nucleation and crystallization of 1. The crystalline intermediate was quenched with ex‐situ experiments. All syntheses performed with this intermediate do not lead to the crystallization of 1 or 2, i.e., there is no direct relation between these three crystalline compounds. The spectroscopic and thermal properties of 1 and 2 are also discussed. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Guanine‐Containing DNA Minor‐Groove Binders
Authors: Pulido Daniel , Sánchez Albert , Robles Jordi , Pedroso Enrique , Grandas Anna 
Published: February 2009

AbstractSolid‐phase procedures have been used to prepare six dipyrrole‐containing DNA ligands that combine (guanin‐9‐yl)acetyl, (guanin‐7‐yl)acetyl or acetyl moieties at the N‐terminal end and two lysines or a (dimethylamino)propyl group at the C terminus. Inspection of their DNA‐stabilizing properties by UV‐monitored thermal denaturation experiments showed that the ligand incorporating the (guanin‐9‐yl)acetyl group and the (dimethylamino)propyl tail had the highest duplex‐stabilizing effects.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Novel Large‐Ring 1,3‐Bridged 2‐Azetidinones as Potential Inhibitors of Penicillin‐Binding Proteins
Authors: Urbach Allan , Dive Georges , Marchand‐Brynaert Jacqueline 
Published: February 2009

AbstractNovel bicyclic 2‐azetidinones, in which the β‐lactam moiety is embedded in a 1,3‐bridging large ring, have been studied experimentally and theoretically. The compounds were prepared from (3S,4R)‐3‐[(1R)‐1‐(tert‐butyldimethylsilyloxy)ethyl]‐4‐propyl‐2‐azetidinone (3) by sequential N1 and O5 functionalization with ω‐alkenyl chains by acylation and/or alkylation reactions. Cyclization by ring‐closing metathesis (RCM) gave a series of 12‐ and 13‐membered‐ring compounds 7, 12b,c, 17b,c and 24 featuring the internal HC=CH double bond with a preferential (E) configuration, and then the corresponding saturated 1,3‐bridged bicycles 8, 13b,c, 18b,c and 25 after hydrogenation. Bridges of 9–11 atoms were inaccessible and bridges of 12 atoms appeared favoured over those with 13 atoms according to ab initio quantum chemistry calculations. This was confirmed experimentally because ω‐alkenyl double‐bond migration occurred in competition with the RCM reaction in the case of 13‐atom precursors, leading to a mixture of 12‐ and 13‐membered rings. Modelling of the reactivity of our 1,3‐bridged 2‐azetidinones, towards hydrolysis and processing by serine enzymes, highlighted the important roles of geometrical and conformational factors and predicted a modest “acylating power” in comparison with classical penam compounds (antibiotics). Biochemical evaluation against the R39 bacterial enzyme (D,D‐peptidase) revealed a weak inhibition effect of the 13‐membered‐ring 1,3‐bridged O,N‐bis(acylated) azetidinones 7 and 8.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
First Stereoselective Synthesis of (1R,2R,4R)‐ and (1S,2R,4S)‐2‐Substituted‐1‐azabicyclo[2.2.1]heptanes
Authors: Etayo Pablo , Badorrey Ramón , Díaz‐de‐Villegas María D. , Gálvez José A. 
Published: February 2009

AbstractThe first stereoselective synthesis of two diastereomeric 1‐azabicyclo[2.2.1]heptanes substituted at the 2‐position from an easily accessible (R)‐2‐substituted‐4‐piperidone is reported. The synthetic route involves the asymmetric one‐carbon homologation of a chiral ketone followed by an intramolecular SN2‐type cyclisation and led to target compounds in high overall yield by using a simple procedure in which purification of the intermediate compounds is not required. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Two dimensions of interpersonal attitudes: Liking depends on communion, respect depends on agency
Authors: Wojciszke Bogdan , Abele Andrea E. , Baryla Wiesław 
Published: February 2009

AbstractLiking and respect are proposed as two dimensions of interpersonal attitudes. Whereas liking–disliking reflects personal preferences, respect–disrespect reflects deference. Four studies involving a variety of samples and target persons showed that: (1) liking is more strongly influenced by communal than agentic qualities of the target, (2) respect is more strongly influenced by agentic than communal qualities of the target, (3) influence of communal information on liking is mediated by the perceived benevolence of the target, (4) influence of agentic information on respect is mediated by the inferred status potential of the target person. Copyright © 2009 John Wiley & Sons, Ltd.
Retributive versus compensatory justice: Observers' preference for punishing in response to criminal offenses
Authors: van Prooijen Jan‐Willem 
Published: February 2009

AbstractIn the current paper, the author examines whether independent observers of criminal offenses have a relative preference for either retributive justice (i.e., punishing the offender) or compensatory justice (i.e., compensating the victim for the harm done). In Study 1, results revealed that participants recommended higher sums of money if a financial transaction was framed as offender punishment (i.e., the offender would pay money to the victim) than if it was framed as victim compensation (i.e., the victim would receive money from the offender). In Study 2, participants were asked to gather information about court trials following three severe offenses to evaluate whether justice had been done in these cases. Results revealed that participants gathered more information about offender punishment than about victim compensation. In Study 3 these findings were extended by investigating whether observers' relative preference for punishing is moderated by emotional proximity to the victim. Results revealed that the relative preference for punishing only occurred among participants who did not experience emotional proximity to the victim. It is concluded that observers prefer retributive over compensatory justice, provided that they do not feel emotionally close to the victim. Copyright © 2009 John Wiley & Sons, Ltd.
Ideological orientation and social context as moderators of the effect of terrorism: The case of Israeli‐Jewish public opinion regarding peace
Authors: Sharvit Keren , Bar‐Tal Daniel , Raviv Amiram , Raviv Alona , Gurevich Ronit 
Published: February 2009

AbstractThe study investigated the effect of severe terror attacks on Israeli‐Jewish public opinion regarding peace in a context of progress toward peace (1994–1997) compared to a context of conflict escalation (2001–2002). We hypothesized that ideological orientations supporting peace (doves) or opposing it (hawks), as well as the social context in which terror occurs, would moderate its effects. We used the database of Peace Index polls, administered monthly to representative samples of Israeli Jews. Polls pose three recurring questions regarding peace. We selected eight polls conducted within a week or less following a severe terror attack, and matched each to a “control” poll, taken at the nearest available time and not preceded by terror. Findings showed that during the 1990s, hawks' opinions regarding peace became less favorable following terror, whereas doves exhibited minimal opinion change. During 2001–2002, however, doves' opinions regarding peace became less favorable following terror, whereas hawks' support for peace increased while their belief in peace did not change. This suggests that the effect of terror on opinions regarding peace varies according to ideological orientations and the transitional context in which terror occurs, implying that contextual factors from multiple levels may interact to affect individuals' opinions. Copyright © 2009 John Wiley & Sons, Ltd.
A Novel Hydrogen Peroxide Biosensor Based on the Synergistic Effect of Gold‐Platinum Alloy Nanoparticles/Polyaniline Nanotube/Chitosan Nanocomposite Membrane
Authors: Wang Xueliang , Yang Tao , Feng Yuanyuan , Jiao Kui , Li Guicun 
Published: February 2009

AbstractBased on the immobilization of horseradish peroxidase (HRP) in chitosan(CS) on a glassy carbon electrode (GCE) modified with the Au‐Pt alloy nanoparticles (NPs) / polyaniline nanotube (nanoPAN) nanocomposite film, a novel hydrogen peroxide biosensor was constructed. The modified processes of GCE were monitored by cyclic voltammetry and electrochemical impedance spectroscopy. Au‐PtNPs/nanoPAN/CS had a better synergistic electrochemical effect than did AuNPs/nanoPAN/CS or PtNPs/nanoPAN/CS. The amperometric response of the biosensor towards H2O2 was investigated by successively adding aliquots of H2O2 to a continuous stirring phosphate buffer solution under the optimized conditions. Because Au‐PtNPs have unique catalytic properties and good biocompatibility, and especially Au‐PtNPs and nanoPAN have synergistic augmentation for facilitating electron‐transfer, the biosensor displayed a fast response time (<2 s) and broad linear response to H2O2 in the range from 1.0 to 2200 μmol L−1 with a relatively low detection limit of 0.5 μmol L−1 at 3 times the background noise. Moreover, the biosensor can be applied in practical analysis and exhibited high sensitivity, good reproducibility, and long‐term stability.
Electrochemiluminescence Characterization of Poly(luminol‐benzidine) Composite Films and Their Analytical Application
Authors: Li Guixin , Zheng Xingwang , Song Ling 
Published: February 2009

AbstractA composite film of poly(luminol‐benzidine) was prepared on the graphite electrode surface by electropolymerizing luminol and benzidine in acidic medium. It was found that the poly(luminol‐benzidine) composite film presented better electrochemiluminescence (ECL) analytical performances for H2O2 than that of the polyluminol film. Based on these findings, a more sensitive ECL sensor for H2O2 was developed. At the same time, our investigating results on this composite film revealed that, as a real ECL luminophor in this composite film, the polymeric 3‐aminophthalate presented higher fluorescence quantum yield than that in the pure polyluminol film, which suggested that the excellent ECL performances of the composite film may originate from the enhancement of the ECL luminophor quantum yield. Based on these results, a new method to improve the ECL analytical performances of the polymeric luminol was also proposed.