bluuebunny/crossref_metadata_2025_split huggingface dataset:
Internal Tides in the Southwestern Japan/East Sea
Authors: Park Jae-Hun , Watts D. Randolph 
Published: February 2006

Abstract
This paper investigates the internal tidal energy distribution in the southwestern Japan/East Sea using vertical round-trip travel time (τ) data from 23 pressure-sensor-equipped inverted echo sounders (PIES). The τ records are analyzed by bandpass filtering to separate time-dependent variability of the semidiurnal and diurnal bands. The semidiurnal internal tides exhibit a horizontal beam pattern of high energy, propagating into the open basin. They originate from a restricted portion of the shelf break where the Korea Strait enters the Ulleung Basin. The generation appears to occur at ∼200-m water depth near 35.5°–35.7°N and 130°–131°E, where the slope of bottom topography matches that of the wave characteristics, coinciding with the location where the semidiurnal barotropic cross-slope tidal currents are strongest. Maximum vertical displacement of the thermocline interpreted as a long-wave first baroclinic mode from the measured τ is about 25 m near the generation region. Annual and monthly variations of the propagation patterns and generation energy levels are observed, and these are closely associated with changes in the mesoscale circulation and stratification. Eastward (westward) refraction is observed when a warm (cold) eddy crosses the path of internal tide propagation. Moreover, when the generation region is invaded by cold eddies that spoil the match between shelf break and thermocline depth, the internal tidal energy level decreases by a factor of about 2. A simple geometric optics model is proposed to explain the observed horizontal refraction of the beam of semidiurnal internal tides in which stratification and current shear play essential roles. In contrast, diurnal internal tides are observed to be trapped along the continental slope region around 36°N.
Lagrangian Observations of the Middepth and Deep Velocity Fields of the Northeastern Atlantic Ocean
Authors: Lankhorst Matthias , Zenk Walter 
Published: February 2006

Abstract
The circulation of the northeastern Atlantic Ocean at intermediate depths is characterized by watermass transformation processes that involve Iceland–Scotland Overflow Water (ISOW) from the northeast, Labrador Sea Water (LSW) from the west, and Mediterranean Water from the south. Field observations were carried out with 89 eddy-resolving floats (RAFOS and MARVOR types). The data coverage achieved is remarkably high and enables a comprehensive study of the eastern basins between Iceland and the Azores. The trajectories show typical pathways of the water masses involved and the role that the complex bottom topography plays in defining them. The ISOW paths tend to lean against the slopes of the Reykjanes Ridge and Rockall Plateau. Westward escapes through multiple gaps in the ridge are possible, superimposed on a sustained southward flow in the eastern basin along the Mid-Atlantic Ridge. LSW pathways leading to the eastern basins are subject to high variability in flow direction and eddy activity. In addition to a selection of characteristic trajectories, maps of the horizontal distributions of Lagrangian eddy kinetic energy and integral time scales are presented. These reveal distinct areas of intensified mixing in the Iceland Basin, as well as the sharp contrast between the subpolar and subtropical dynamics. A self-contained eddy detection scheme is applied to obtain statistics on individual eddy properties and their abundance. It is suggested that much of the intensified mixing can be related to cyclonic activity, particularly in the subpolar region.
Globalization and the Logic of Participation: Unions and the Politics of Coalition Building
Authors: Turner Lowell 
Published: February 2006

Global liberalization is driving a ‘logic of participation’, for firms and unions alike. Economic pressures drive managers to innovate across a range of possibilities, from outsourcing and union busting to work reorganization and labor-management partnership. Those same pressures, reflected largely through the strategic choices of employers, also force unions to innovate - from concession bargaining and cooperation to coalition building and international solidarity. Because employers are increasingly tempted by strategies that seek to weaken or marginalize unions, sustained participation for unions arguably requires a new period of activist mobilization. This article explores one significant component of renewed labor mobilization: union coalition building. Based on a case study of coalition efforts in the United States between the United Steelworkers and the Sierra Club from 1999-2004, concepts and causal linkages are suggested for broader analysis. Research findings presented here indicate the following causal processes at work: union strategies, defining moments and spillover combine to drive coalition building processes that include events, campaigns and institution building - ranging from local to national and global levels. Beyond this US-based case, a framework for cross-national comparative analysis is also suggested.
Cross-talk of the renin-angiotensin and kallikrein-kinin systems
Authors: Shen Bing , El-Dahr Samir S. 
Published: February 2006

Abstract
The renin-angiotensin (RAS) and kallikrein-kinin (KKS) systems play a key role in multiple physiological and pathophysiological conditions, including growth and development, inflammation, blood pressure regulation and control of renal function. In many instances, kinins and angiotensin II work together, e.g., during development, whereas they oppose each other's actions in the regulation of vascular tone and renal function. The RAS and KKS systems also interact at multiple levels, so that changes in the activity of one system greatly impact the activity of the other. The purpose of this brief review is to highlight recent knowledge regarding interactions at the cellular and molecular levels between the two systems, with an emphasis on the coordinate developmental regulation of these phylogenetically conserved vasoactive systems.
Anti-inflammatory effects of kinins via microglia in the central nervous system
Authors: Noda Mami , Kettenmann Helmut , Wada Keiji 
Published: February 2006

Abstract
Kinins are important biologically active peptides that are up-regulated after lesions in both the peripheral and central (CNS) nervous systems. Microglia are immune cells in the CNS and play an important role in the defense of the neuronal parenchyma. In cultured murine microglia, bradykinin (BK) induces mobilization of intracellular Ca2+, microglial migration, and increases the release of nitric oxide and prostaglandin E2. On the other hand, BK attenuates lipopolysaccharide-activated TNF-α and IL-1β release. These results suggest that BK functions as a signal in brain trauma and may have an anti-inflammatory role in the CNS.
The role of bradykinin B1 receptor on cardiac remodeling in stroke-prone spontaneously hypertensive rats (SHR-SP)
Authors: Moniwa Norihito , Agata Jun , Hagiwara Makoto , Ura Nobuyuki , Shimamoto Kazuaki 
Published: February 2006

AbstractAn angiotensin-converting enzyme inhibitor (ACE-I) reduces cardiac remodeling and a bradykinin B2 receptor (B2R) antagonist partially abolishes this ACE-I effect. However, bradykinin has two different types of receptor, the B1 receptor (B1R) and B2R. Although B1R is induced under several pathological conditions, including hypertension, the role of cardiac B1R in hypertension is not clear. We therefore investigated the role of cardiac B1R in stroke-prone spontaneously hypertensive rats (SHR-SP) and Wistar-Kyoto (WKY) rats. The B1R mRNA expression level in the heart was significantly higher in SHR-SP than in WKY rats. Chronic infusion of a B1R antagonist for 4 weeks significantly elevated blood pressure and left-ventricular weight of SHR-SP. Morphological analysis indicated that cardiomyocyte size and cardiac fibrosis significantly increased after administration of the B1R antagonist. The phosphorylation of mitogen-activated protein (MAP) kinases, including ERK, p38, and JNK, was significantly increased in the hearts of SHR-SP rats receiving the B1R antagonist. The TGF-β1 expression level was significantly increased in SHR-SP rats treated with the B1R antagonist compared to that in WKY rats. The B1R antagonist significantly increased phosphorylation of Thr495 in endothelial nitric oxide synthase (eNOS), which is an inhibitory site of eNOS. These results suggest that the role of B1R in the heart may be attenuation of cardiac remodeling via inhibition of the expression of MAP kinases and TGF-β1 through an increase in eNOS activity in a hypertensive condition.
Molecular identification and pharmacological profile of the bovine kinin B1 receptor
Authors: Morissette Guillaume , Marceau François 
Published: February 2006

AbstractTo support the study of kinin pharmacology in bovine models of cultured endothelial cells (ECs), the Bovine Genome Project was searched for a B1receptor (B1R) gene ortholog (BDKRB1). A contig complementary to an intronless coding nucleotide sequence was found. The sequence was amplified from bovine EC DNA, further cloned into pcDNA3 and expressed in COS-1 cells. The bovine B1R sequence was confirmed and extended. A putative Zn2+-binding motif HEXXH is not present (replaced by HDAWP). The receptor binds [3H]Lys-des-Arg9-bradykinin in a saturable manner (Kd0.36 nM) and exhibits a pharmacological profile similar to that of human B1R.
Measurement of glycated hemoglobin (HbA1c) with an automated POCT instrument in comparison with HPLC and automated immunochemistry method: evaluation of the influence of hemoglobin variants
Authors: Haliassos Alexander , Drakopoulos Ioannis , Katritsis Demosthenes , Chiotinis Nikolaos , Korovesis Socrates , Makris Konstantinos 
Published: February 2006

AbstractOur study evaluates a fast and easy way to perform point-of-care testing (POCT) measurements of glycated hemoglobin HbA
Inhibiting radiolysis of BTP molecules by addition of nitrobenzene
Authors: Nilsson M. , Andersson Sofie , Ekberg C. , Foreman M. R. S. , Hudson M. J. , Skarnemark G. 
Published: February 2006

Summary
Autoradiolysis of extraction systems sometimes occurs during reprocessing of spent fuel, which may result in a change in the extraction behaviour of the system. In the work reported here, an aromatic heterocyclic nitrogen bearing tridentate extraction agent, 2,6-di(5,6-diethyl-1,2,4-triazin-3-yl)pyridine (a BTP), was irradiated using a 60Co source. The investigation focused on the effect of changing the organic diluent in the extraction system in order to protect the extracting agent from degradation.
A relationship between the distribution ratio and extracting agent concentration was determined, and it was found that the extraction efficiency decreased with increasing irradiation dose.
The effect on extraction of the degradation products from the organic diluents was also considered.
Preparation of [61Cu]pyruvaldehyde-bis (N
4-methylthiosemicarbazone) complex as a possible PET radiopharmaceutical
Authors: Jalilian A.R. , Rowshanfarzad P. , Sabet M. 
Published: February 2006

Summary
Copper-61 (T1/2= 3.33 h) produced via the natZn(p,x) 61Cu nuclear reaction using natural zinc target, was separated from the irradiated target material by a two-step method developed in our laboratory and was used for the preparation of [61Cu]-pyruvaldehyde- bis (N4-methylthiosemicarbazone) ([61Cu]-PTSM) using an in house-made PTSM ligand. An electroplated natural zinc layer on a gold-coated copper backing (zinc and gold layer thicknesses were 80 and 50 μm respectively) was irradiated with 22 MeV; protons (22−12 MeV; on the target). 61Cu was separated by a two-step chromatography method using a cation and an anion exchange column which gave satisfactory results. After 180 μA irradiation of the target for 3.2 hours, about 6.006 Ci of 61Cu2+ was obtained with a radiochemical separation yield of more than 95% and a radionuclidic purity of more than 99% (60Cu as impurity). Colorimetric methods showed that traces of chemical impurities in the product were below the accepted limits. The solution of [61Cu]-PTSM was prepared with a radiochemical yield of higher than 80%, radiochemical purity of better than 98% and specific activity of about 246 Ci/mmol.
Measurement of fission neutron spectrum averaged cross sections of some threshold reactions on zinc: small-scale production of no-carrier-added 64Cu in a nuclear reactor
Authors: Abbasi I. A. , Zaidi Jamshed H. , Arif M. , Subhani Muhammad Sadiq 
Published: February 2006

Summary
Fission neutron spectrum averaged cross sections of some threshold reactions like (n,p), (n, α) and (n,2n) on zinc were measured using the activation technique in combination with radiochemical separations and high-resolution γ-ray spectroscopy. Special attention was paid to the formation of 64Cu via the 64Zn(n,p) 64Cu reaction since 64Cu labeled compounds are potentially important radiopharmaceuticals. At a fast neutron flux density of 7.5 × 1013 cm-2s-1 and using a 100% enriched 64Zn target, 35 GBq activity of no-carrier-added 64Cu per batch could be produced. The process seems to be interesting from the medical application viewpoint, if a cyclotron is not available. A fast neutron source, on the other hand, would lead to significantly higher yield of 64Cu.
Interaction of neptunium(V) with picolinic, nicotinic and isonicotinic acids
Authors: Budantseva Nina A. , Andreev Grigory B. , Fedoseev Alexander M. , Antipin Mikhail Yu. , Krupa Jean-Claude 
Published: February 2006

SummaryThe interaction of Np(V) with all isomers of pyridinemonocarboxylic acid has been investigated, stability constants have been calculated using NIR spectroscopy. Single crystals of [NpO2(Pic)(H2O)2] (1), Cs[NpO2(Pic)2(HPic)]·3H2O (2), [NpO2(Nic)(H2O)] (3), and [NpO2(iso-Nic)(H2O)] (4) have been synthesized. Compound1contains infinite chains; compound2consists of isolated Cs+, [NpO2(Pic)2(HPic)]-groups and water molecules. In both3and4neptunoyl-ion NpO2acts as monodentate ligand with one of the O atoms of NpO2group entering in coordination polyhedron of the adjacent Np atom. Compounds3and4have layered and three-dimensional topologies, respectively. Crystallographic data: [NpO2(Pic)(H2O)2], space groupP¯1, triclinic,a= 6.380(2),b= 7.733(2),c= 10.700(4) Å, α = 96.49(3), β = 106.78(3), γ = 103.83(3)°, andZ= 2 (1); Cs[NpO2(Pic)2(HPic)]·3H2O, space groupP¯1, triclinic,a= 8.707(2),b= 9.777(2),c= 14.640(3) Å, α = 76.633(15), β = 78.75(2), γ = 86.55(2)°, andZ= 2 (2); [NpO2(Nic)(H2O)], space groupP21/n, monoclinic,a= 11.901(4),b= 5.5628(15),c= 12.124(3) Å, β = 101.05(2)°, andZ= 4 (3); [NpO2(iso-Nic)(H2O)], space groupP212121, orthorhombic,a= 5.742(3),b= 8.550(5),c= 18.512(10) Å, andZ= 4 (4). Electron and IR spectra of solid compounds have been measured.
Sorption of radionuclides from complexone solutions in liquid CO2
Authors: Shafikov D. , Kamachev V. , Murzin A. , Babain V. A. , Shadrin A. 
Published: February 2006

Summary
Sorption of 241Am and 137Cs on ion-exchange resins with different functional groups from complexone solutions in liquid CO2 was investigated. It was shown that more than 99% of radionuclides could be recovered from liquid CO2 by using strongly acidic resins or H2C2O4·2H2O. Ion-exchange capacity of KU2-8 (analog of DOWEX-50-8) in liquid CO2 was estimated.
Photochemical behaviour of Tc2OCl10
4– and TcnOy
4n–2y+ in chloride media
Authors: Poineau Frédéric , Fattahi Massoud , Grambow Bernd 
Published: February 2006

Summary
The stabilities of the technetium polymers Tc2OCl10
4− and TcnOy
4n−2y+ have been studied under light irradiation in 3 M chloride media with a pH range from 0 to 1.3. It has been shown that under irradiation, Tc2OCl10
4− is not stable and undergoes dissociation to TcCl5(H2O)- at pH = 0 and pH = 0.3. At pH = 1, irradiation of Tc2OCl10
4− leads to a stationary state involving TcCl5(H2O)- and Tc2OCl10
4−. At pH = 1.3, TcnOy
4n−2 y+ remains stable under irradiation. Under light irradiation, the predominance diagram of Tc(IV) species obtained from Tc2OCl10
4− aquation in a pH range from 0 to 1 is drawn.
The chemical behaviour of Tc2OCl10
4− and the influence of the light on the condensation of Tc(IV) and solubility of TcO2· x H2O are discussed.
A Discrete Time Model for Pricing Treasury Bills, Forward, and Futures Contracts
Authors: Morgan I.G. , Neave E.H. 
Published: February 2006

AbstractThis paper develops a discrete time model for valuing treasury bills and either forward or futures contracts written against them. It provides formulae for bill prices, forward prices, futures prices, and their conditional variances and risk premiums. The interest rate process is described by a multiplicative binomial random walk whose features conform to some principal characteristics of observed processes. Initial forward rates are constrained to match initially observed term structure data.
A Class of Conjugate Priors with Applications to Excess-of-Loss Reinsurance
Authors: Hesselager Ole 
Published: February 2006

AbstractWe consider the problem of forecasting the total cost of claims in excess-of-loss reinsurance. The number of claims reported to the direct insurer is assumed to follow a Poisson law, and the claim severities are modelled by a Pareto distribution. The Poisson frequency as well as the Pareto parameter will be considered as random parameters in a Bayesian setting. We derive the class of conjugate joint prior distributions, which turn out to specify a (prior) dependence between the two parameters. The use of conjugate priors facilitates the mathematical analysis, and it also makes it easy to interpret the parameters of the prior distribution.
Unilateral uveitis in a dog with uveodermatologic syndrome
Authors: Sigle Kelly J. , McLellan Gillian J. , Haynes Joseph S. , Myers Ronald K. , Betts Daniel M. 
Published: February 2006

Abstract
Case Description—A 7-year-old Siberian Husky-type dog with heterochromia irides was evaluated because of signs of pain associated with the right eye.
Clinical Findings—Unilateral panuveitis, iris bombé, and secondary glaucoma were detected in the right eye. Tear production was low bilaterally. Facial and truncal poliosis and vitiligo were also evident; skin biopsy specimens were obtained from the nasal planum. Uveodermatologic syndrome was diagnosed on the basis of histopathologic findings of a lichenoid interface dermatitis and pigmentary incontinence within the dermis. Immunohistochemical analysis was performed on skin samples retrospectively, and findings were inconclusive.
Treatment and Outcome—Treatment involved topical (ocular) and oral administration of corticosteroids, oral administration of azathioprine, and topical (ocular) administration of a carbonic anhydrase inhibitor and a lacrimostimulant. The secondary glaucoma was refractory to treatment, and the right eye was enucleated. Uveodermatologic syndrome was confirmed via histologic examination of ocular tissues. The left eye remained free of inflammation 16 months after the initial diagnosis. The periocular skin and skin of the nose partially regained pigment, but the hair did not.
Clinical Relevance—Some breeds in which uveodermatologic syndrome has been reported (eg, Siberian Huskies, Old English Sheepdogs, Australian Shepherds, and Shetland Sheepdogs) often have heterochromia irides. This case highlights the fact that dogs with asymmetric uveal pigmentation may have unilateral ocular changes; therefore, uveodermatologic syndrome should not be excluded as a differential diagnosis on the basis of unilateral clinical signs.
The Biologically Active Biopolymer Silk: The Antibacterial Effects of Solubilized Bombyx mori Silk Fibroin with Common Wound Pathogens
Authors: Egan Gemma , Hannah Aiden J. , Donnelly Sean , Connolly Patricia , Seib F. Philipp 
Published: February 2024

AbstractAntibacterial properties are desirable in wound dressings. Silks, among many material formats, have been investigated for use in wound care. However, the antibacterial properties of liquid silk are poorly understood. The aim of this study is to investigate the inherent antibacterial properties of a Bombyx mori silk fibroin solution. Silk fibroin solutions containing ≥ 4% w/v silk fibroin do not support the growth of two common wound pathogens, Staphylococcus aureus and Pseudomonas aeruginosa. When liquid silk is added to a wound pad and placed on inoculated culture plates mimicking wound fluid, silk is bacteriostatic. Viability tests of the bacterial cells in the presence of liquid silk show that cells remain intact within the silk but could not be cultured. Liquid silk appears to provide a hostile environment for S. aureus and P. aeruginosa and inhibits growth without disrupting the cell membrane. This effect can be beneficial for wound healing and supports future healthcare applications for silk. This observation also indicates that liquid silk stored prior to processing is unlikely to experience microbial spoilage.
Ferroptosis in Glaucoma: A Promising Avenue for Therapy
Authors: Zhu Jingyun , Chen Hui , Wu Jian , Li Sen , Lin Wanying , Wang Ningli , Bai Lang 
Published: February 2024

AbstractGlaucoma, a blind‐leading disease largely since chronic pathological intraocular high pressure (ph‐IOP). Hitherto, it is reckoned incurable for irreversible neural damage and challenges in managing IOP. Thus, it is significant to develop neuroprotective strategies. Ferroptosis, initially identified as an iron‐dependent regulated death that triggers Fenton reactions and culminates in lipid peroxidation (LPO), has emerged as a focal point in multiple tumors and neurodegenerative diseases. Researches show that iron homeostasis play critical roles in the optic nerve (ON) and retinal ganglion cells (RGCs), suggesting targeted treatments could be effective. In glaucoma, apart from neural lesions, disrupted metal balance and increased oxidative stress in trabecular meshwork (TM) are observed. These disturbances lead to extracellular matrix excretion disorders, known as sclerotic mechanisms, resulting in refractory blockages. Importantly, oxidative stress, a significant downstream effect of ferroptosis, is also a key factor in cell senescence. It plays a crucial role in both the etiology and risk of glaucoma. Moreover, ferroptosis also induces non‐infectious inflammation, which exacerbate glaucomatous injury. Therefore, the relevance of ferroptosis in glaucoma is extensive and multifaceted. In this review, the study delves into the current understanding of ferroptosis mechanisms in glaucoma, aiming to provide clues to inform clinical therapeutic practices.