bluuebunny/crossref_metadata_2025_split huggingface dataset:
DE CAUSIS LINGUAE LATINAE: EPÍSTOLA INTRODUTÓRIA E ALGUNS COMENTÁRIOS
Authors: Mayne Ribeiro da Silva Marcelle , Frohwein de Salles Moniz Fábio 
Published: March 2024

Apresentamos, neste trabalho, a tradução da epístola introdutória do “De causis linguae latinae” (DCLL), de Júlio César Escalígero (1540). Na epístola, endereçada ao tipógrafo Sebastian Grífio, Escalígero justifica e explica o ineditismo e a necessidade de sua obra; não é só mais um compêndio de gramática, mas uma nova forma de abordagem dos fenômenos gramaticais. Por isso, antecedendo nossa tradução, realizamos um pequeno estudo abordando o contexto sócio-histórico de produção e circulação da obra, além de um resumo do conteúdo geral do DCLL. Aliado a isso, tecemos alguns comentários sobre o texto traduzido, a fim de evidenciarmos não só a importância do DCLL, mas também a do tipógrafo na divulgação e prestígio dela.
Review of Forensic Medicine and Toxicology
Authors: Waghmode Dr. Avinash H. , Bodkha Dr. Pravir , Phad Dr. Laxman G. 
Published: March 2024

This book entitled “Review of Forensic Medicine and Toxicology” based on Recent Competency Based Medical Education (CBME), is specially intended for the undergraduate students and those candidates preparing for NEET PG entrance examination and FMGE examination.
Various colour photographs of Post-mortem changes, Mechanical injury, Weapons and Poisons are incorporated in the book.
This book will strengthen the foundation of undergraduates in 2nd and 3rd phase of MBBS curriculum.
Important facts to remember are added at the end of each chapter.
This book will contain multiple choice questions (MCQ's) asked in AI, NEET PG entrance examinations and various questions (SAQ's and LAQ's) asked in theory examinations of different universities.
This book will be also useful for Medical Officers during their antemortem and post-mortem examination.
This will also provide opportunity for students to do a project and enhance self-directed learning.
Aktivitas Pasar Tradisional Sebagai Inspirasi Motif Fashion Dengan Teknik Digital Printing
Authors: Ariesta Ghina , Kherid Zaitun Y.A , Mudjiati  
Published: March 2024

Perancangan ini bertujuan untuk memvisualisasikan serta penyampaian pesan nilai-nilai positif seperti gotong royong, interaksi sosial, tekun dan gigih mencari nafkah, masyarakat yang multikultural dan nilai positif lainnya di tengah meningkatnya pasar modern dan online yang minim lebih interaksi sosial ke dalam desain motif fashion dengan teknik digital print untuk segmentasi masyarakat perkotaan terutama dengan pergerakan mobilitas yang tinggi dan cepat menyerap informasi. Pesatnya pertumbuhan fashion di Indonesia terutama dengan teknik digital print yakni salah satu jenis desain permukaan dengan penambahan corak di atas kain polos (desain struktur). Berdasarkan tujuan tersebut, penciptaan karya tugas akhir ini menggunakan metode pengumpulan data kualitatif antara lain berdasarkan studi pustaka melalui sumber-sumber bacaan, angket atau kuesioner yang perupa bagikan kepada konsumen dengan segmentasi wanita dewasa awal usia 21-30 tahun yang berdomisili di Jakarta, Bogor, Depok, Tangerang, Bekasi, Bandung dan Yogyakarta, observasi jenis kain serta eksplorasi motif dan desain busana. Secara garis besar, penciptaan motif ini menitikberatkan pada eksplorasi pengembangan karakter, penyusunan tata letak elemen desain dan permainan warna yang diolah sehingga tercipta suatu desain yang harmonis sebagai media penyampaian pesan. Hasil akhir motif tersebut diaplikasikan kedalam empat buat karya busana wanita kasual yang masing-masing memiliki tata letak elemen desain dan warna yang berbeda.
Two-Stage Model of Devonian Basic Magmatism in the Vilyui Paleorift (Siberian Platform)
Authors: Polyansky O.P. , Simonov V.A. , Koroleva O.V. , Prokopiev A.V. , Babichev A.V. , Kotlyarov A.V. , Semenov A.N. 
Published: March 2024

Abstract
—We report study results of basic intrusive bodies in the middle Paleozoic Vilyui paleorift (eastern Siberian Platform). Geochemical data for basic sills penetrated by boreholes in the rift’s dike swarms are presented, as well as our data on the time of formation of sills and dikes. We also studied mineral-hosted melt inclusions from a dolerite dike of the Vilyui–Markha dike swarm on the northwestern flank of the Vilyui paleorift. Data on the compositions of homogenous glasses of mineral-hosted melt inclusions yielded the P–T parameters of mantle sources of basic melts responsible for the formation of the Vilyui paleorift gabbro-dolerites. Two depth levels of basic melt generation have been established: 95–65 km at 1480–1400 °C and 55–45 km at 1360–1320 °C. Crystallization of the melts occurred at a shallow depth of 12–4 km with a decrease in temperature from 1185 to 1125 ºС. This occurrence of basic melt sources at two different depths, as well as the heterogeneity of the chemical composition of melt inclusions and their host minerals explains the presence of two pulses of Devonian basic magmatism. Our new numerical thermomechanical model of magma rise during melting of the lithospheric mantle above a mantle plume supports the existence of two chambers at the spinel–garnet peridotite boundary and under the base of the crust, as well as the two-stage nature of Devonian magmatism.
Legal Approaches and Regulatory Methods for Fintech in the Guangdong – Hong Kong – Macao Greater Bay Area
Authors: Kuchina Y. 
Published: March 2024

Objective: To look at the fintech regulatory policy and regulatory system in the Greater Bay Area through the lens of the Trilemma of Innovation doctrine in order to identify the applicability and extrapolation of existing legal models in the zone of accelerated economic and innovation development in Guangdong, Hong Kong and Macau.Methods: The article is based on the comparative legal research of the regulation regarding models, existing within the regulatory framework for fintech. For that matter we conduct a generalization, introducing the classification of methods and systems that, in our opinion, can be recognized as the Lego-like systems of instruments.Results: The research evaluates difficulties that may be faced by the participants within GBA on the way of legal harmonization regarding fintech. Special attention is paid to Hong Kong SAR, being one of the bestknown examples of successful fintech regulation, and to comparing fintech regulation in Mainland China and in SAR (Macau, in particular). The author states that the last amendments to the financial law of Macau SAR also add an element of uncertainty, even though they aim to develop the situation within the framework. The author compares a technocratic approach, according to which fintech regulation is completely national (created only for the domestic market and reflects its structure) and traditional approach to regulation, a part of which is the Trilemma of Innovation. The latter implies the possibility of over-national (international) standardization, including in the form of soft law, which may eliminate the difference in understanding the fintech characteristics, its concepts and scope. Besides, the author analyses the correlation between the concepts of financial regulatory system and financial system of fintech regulation, extrapolation of the existing regulatory framework to the developing market of innovative technological solutions and their various models. The author highlights the regulatory response method, changing during the fintech market evolution, and applied, as a rule, together with other approaches.Scientific novelty: the article presents a comprehensive review of the different systems of fintech legal regulation in the Guangdong – Hong Kong – Macau Greater Bay Area, whose unique experience demonstrates various trajectories of the fintech market development in southern China within the “One Country – Two Systems” concept.Practical significance: the main conclusions and proposals resulting from the study are of significant interest for further research, regulatory policy and fintech regulatory system, as Mainland China and the special administrative regions of the Greater Bay Area use different approaches and methods of legal response that have no analogues in the modern world.
Impact of New Technologies on Economic Behavior and Consumer Freedom of Choice: from Neuromarketing to Neuro-Rights
Authors: Sposini L. 
Published: March 2024

Objective: to identify the possibilities for an adequate response of the existing legal regime to the various challenges posed to European law by artificial intelligence systems underlying neuromarketing techniques.Methods: the study is based on the risk-oriented approach, formal-logical, formal-legal and comparative-legal methods, as well as on the method of legal forecasting, in order to identify the problems of legislation caused by the emerging technologies capable of recognizing human emotions and using them to control consumer behavior, and to propose ways to solve them.Results: the conducted research provides a brief overview of the most widely used neuromarketing techniques used by algorithms and machine learning. These allow identifying points of cognitive and emotional vulnerability, collecting and processing data, and then building the most effective marketing techniques that push a consumer to choose a certain product or service. Ethical problems are analyzed which arise from the use of neuromarketing techniques in relation to some basic values such as individual independence, human dignity, and freedom of choice. The subtle line is shown between techniques that manipulate consumer behavior (manipulation technique) and those that, on the contrary, have a persuasive effect, which in itself does not make them illegal (persuasion technique). An overview of the existing legal framework is presented, as well as case law from both the European Court of Justice and national courts of member states with a particular focus on the Unfair Commercial Practices Directive, the EU General Regulation on the Protection of Personal Data (hard law), and codes of ethics (soft law).Scientific novelty: the paper points out the transformation of traditional legal categories and important problem points of the existing regulation due to the growing recognition of the potential of neuromarketing as a tool capable of explaining and predicting consumer behavior, as well as influencing the economic behavior of the subjects of relations.Practical significance: the obtained conclusions and proposals can be taken into account in improving the regulation of artificial intelligence in terms of its safety and reliability, increasing trust in the system, given the need to protect ethical principles and maintain fundamental values.
Funding and its impact on the administration and organisational efficiency of technical vocational education and training institutions
Authors: Mack Abede 
Published: March 2024

Abstract

In the present study, the author examines how the lack of funding can impact the administration and the organisational efficiency of technical vocational education and training (TVET) institutions (I). The research examines human capital development and TVET as instruments for propelling growth and development and contributing to Trinidad and Tobago’s (T&T) economic and social advancements. The study explored how TVETIs can be a central pillar in the progress of T&T’s development. The research material consists of 10 interviews with educational experts from four postsecondary TVETIs in T&T and the chief executive of T&T TVET’s regulatory body. Focus groups and individual interviews were conducted with the leading regulator, instructors, managers, and a curriculum expert. The author utilised thematic analysis in the research by adopting a deductive approach. The data revealed several challenges that engulf the administration and management of TVETI in T&T, mainly because of financial woes. Three themes emerged from the data: Funding for Administration, Funding for Human Capital Development and Funding for Organisational Efficiency. Insightful revelations were unearthed from the educational experts, which were generated from the data which provide an in-depth perspective on the administration and management of TVET in T&T. The results show that T&T’s education experts see funding as a significant challenge. Many argue that a lack of funding severely impacts their institutions, which erodes human capital development growth. The study concludes that a lack of funding can severely and has impacted TVET in several ways. An absence or a lack of funding brought the closure of top-notch schools used in the training and growth of teachers for the educational system. Human capital development and TVET were also highlighted as essential tools for economic and social deprivation. However, a better approach is needed to finance TVET moving forward.
A comparative whole genome comparison analysis of Helicobacter pylori from gastric cancer and gastritis in China setting
Authors: Kong Pengfei , Yan Yong-hao , Duan Yan-tao , Fang Yan-tian , Dou Yi , Xu Yong-hu , Xu Da-zhi 
Published: March 2024

Abstract
Background: This study aimed to explore and compare the differences in the genomics and pathogenicity of Helicobacter pylori (H. pylori) strains derived from the gastric cancer (GC) and gastritis (GI) in the Chinese population.
Methods: We sequenced 12 H. pylori from GC and GI patients in china by whole genome sequencing. 20 H. pylori sequencing data from other regions of the world were obtained from the public platform as reference genes. Then, the evolutionary tree was drawn based on multi-omics, and the differences of virulence factors (VF) and gene function were analyzed
Results: In GC stains, the 1544-1640 coding genes, with a total length of 1,549,790-1,605,249 bp, were predicted. In GI stains, the 1552-1668 coding genes, with a total length of 1,552,426-1,665,981 bp, were identified. In addition, the average length of coding genes in GC and GI strain, was approximately 1594 (90.91%) and 1589 genes (90.81%), respectively. We found that the VFs predicted by the two cohort strains had high consistency, but their cagA status was significantly different. Additionally, the clustering results indicated that there were significant differences in core Single Nucleotide Polymorphism (SNP) between GC and GI strains, but no significant differences in homologous proteins and gene island prediction between the two strains. Subsequently, the results of pan-genomic and Average Nucleotide Identity (ANI) analyses suggested that GC, GI and other reference H. pylori strains had high homology consistency. Furthermore, the gene function annotation results suggested that the H. pylori strains of GC and GI also had high similarity in gene function, and their specific gene functions were mainly concentrated in the process of metabolism, transcription and repair.
Conclusions: GC and GI patient-derived H. pylori have some differences in VF and SNP, but they also have high homologous consistency at other level of the genome in Chinese population.
Repetitive stability study of Remdesivir/Cyclodextrin complex on ISS
Authors: Dormán György , Buchholcz Balázs , Puskás István , Szabó Pál , Varga Erzsébet , Szente Lajos , Keserű György M. , Darvas Ferenc 
Published: March 2024

Abstract

Stability assessment of drugs in space is particularly important for future missions., In space there are multiple factors, such as the variability of the conditions (radiation, microgravity, vacuum etc.) that could affect the reliability and reproducibility of the data. Therefore, we investigated the stability of an anti-Covid drug formulation, Remdesivir (RDV) sulfobutylether-beta-cyclodextrin (SBECD) complex, in two separate flight experiments on the International Space Station (ISS). While HPLC/MS studies revealed no degradation of the cyclodextrin excipient in any of the samples investigated in both missions, RDV purity analysis of the RDV/SBECD complex after the first mission revealed different stabilities and altered degradation in space and on Earth. This latter interesting finding was not supported by the second mission, where no differences in the drug stabilities were identified. This anomaly highlighted the importance of standardization together with increased control of the variable parameters during the entire space missions and the terrestrial control experiments.
Estimation of water saturation based on optimized models in tight gas sandstone reservoirs: A case study of Triassic Xujiahe Formation in northwestern Sichuan Basin
Authors: Xia Xiaoyong , Han Bing , Xie Bing , Lai Qiang , Wang Yuexiang , Zhu Shaowu 
Published: March 2024

Abstract
Water saturation estimation faced a great challenge in tight gas sandstone reservoirs because of the effect of pore structure and strong heterogeneity to rock resistivity. The classic Archie’s equation cannot be always well used. To quantify the effect of pore structure to rock resistivity in tight gas sandstones, taking the Triassic Xujiahe Formation of northwestern Sichuan Basin as an example, 35 core samples were recovered and applied for resistivity experiments in laboratory under the simulated formation temperature and pressure environment, and 18 of them were simultaneously applied for nuclear magnetic resonance (NMR) and high-pressure mercury injection (HPMI) experimental measurements. Relationships between rock pore structure and resistivity parameters were analyzed. The results clearly illustrated that cementation exponent (m) and saturation exponent (n) were heavily affected by pore structure. Rocks with superior pore structure contained relative higher cementation exponent and lower saturation exponent, and vice versa. Afterwards, we raised a parameter of pore size index, which was defined as the ration of macropore and micropore percentage contents, to reflect rock pore structure, and established a model to calculate optimal saturation exponent from NMR data. Meanwhile, various cementation exponent prediction model was also raised by combining with porosity and irreducible water saturation (Swirr). By combining with calculated cementation exponent and saturation exponent, we optimized the Archie’s equation to predict water saturation in our target tight gas sands. Field examples illustrated that the predicted cementation exponent and saturation exponent matched well with core-derived results. The absolute errors between predicted cementation exponent and saturation exponent with core-derived results were lower than 0.05 and 0.07, separately. By using the optimized Archie’s equation, water saturations were precisely predicted from well logging data in our target tight gas sandstone reservoirs.
Prevalence and epidemic pattern of ecdemic multidrug-resistant tuberculosis during 2012- 2022 in Hangzhou, China: implication for public health strategies
Authors: Li Qingchun , Wu Yifei , Cheng Qinglin , Lu Min , Huang Yinyan , Bai Xuexin , Jia Qingjun , Fang Zijian , Ai Liyun , Jiang Nan , Lao QiuFeng , Xie Li , Chen Junfang 
Published: March 2024

Abstract

Background
To assess the prevalence and epidemic pattern of multidrug-resistant tuberculosis in Hangzhou City, Zhejiang Province, China during 2012–2022.
Methods
All the tuberculosis cases undergoing drug susceptibility testing during 2012–2022 were included in this study. De-identified information was extracted from the electronic database Tuberculosis Information Management System for analysis of drug resistance prevalence in Hangzhou and ecdemic multidrug-resistant tuberculosis which originated from other regions. Chi-square tests were used to compare drug resistance rates between different groups, while Chi-square tests for trend were used to evaluate the change of drug resistance rates over the years of 2012–2022. The sources and destinations of ecdemic multidrug-resistant tuberculosis were illustrated using a Sankey diagram.
Results
Of 21,127 cases included in this study, 1119 (5.3%) were multidrug-resistant tuberculosis. A significant decline in multidrug-resistant tuberculosis rates was observed during 2012–2022. There was a significant difference in multidrug-resistant tuberculosis rates among immigrant population and local residents in Hangzhou City. Of 1119 multidrug-resistant tuberculosis cases, 515(46%) were ecdemic multidrug-resistant tuberculosis cases, of which 277(53.8%) were from other parts of Zhejiang Province and 238(46.2%) were from other provinces in China. Anhui, Jiangxi and Sichuan were among top three provinces which were the source of ecdemic multidrug-resistant tuberculosis cases. Three districts including Xiaoshan, Shangcheng and Linping districts had the most cases in Hangzhou. The proportion of ecdemic multidrug-resistant tuberculosis cases in Binjiang, Xiaoshan, Qiantang and Linping districtalso exceeded 30% of total cases.
Conclusions
Multidrug-resistant tuberculosis prevalence has been declining in Hangzhou. Migrant population contributed to a significant potion of cases in Hangzhou. Interventions should be tailed to local and migrant residents.
Effects of walking on epigenetic age acceleration: a Mendelian randomization study
Authors: Chen Guanyi , Liu Chao , Xia Yu , Wang Pingxiao , Zhao Ziyue , Li Ao-yu , Zhou Chuqiao , Xiang Cheng , Zhang Jialin , Zeng Yi , Gu Peng , Li Hui 
Published: March 2024

Abstract

Introduction
: Walking stands as the most prevalent physical activity in the daily lives of individuals and is closely associated with physical functioning and the aging process. Nonetheless, the precise cause-and-effect connection between walking and aging remains unexplored. The epigenetic clock emerges as the most promising biological indicator of aging, capable of mirroring the biological age of the human body and facilitating an investigation into the association between walking and aging. Our primary objective is to investigate the causal impact of walking with epigenetic age acceleration (EAA).
Methods
We conducted a two-sample two-way Mendelian randomization (MR) study to investigate the causal relationship between walking and EAA. Walking and Leisure sedentary behaviour data were sourced from UK Biobank, while EAA data were gathered from a total of 28 cohorts. The MR analysis was carried out using several methods, including the inverse variance weighted (IVW), weighted median, MR-Egger, and Robust Adjusted Profile Score (RAPS). To ensure the robustness of our findings, we conducted sensitivity analyses, which involved the MR-Egger intercept test, Cochran’s Q test, and MR-PRESSO, to account for and mitigate potential pleiotropy.
Results
The IVW MR results indicate a significant impact of usual walking pace on GrimAge (BETA = -1.84, 95% CI (-2.94, -0.75)), PhenoAge (BETA = -1.57, 95% CI (-3.05, -0.08)), Horvath (BETA = -1.09 (-2.14, -0.04)), and Hannum (BETA = -1.63, 95% CI (-2.70, -0.56)). Usual walking pace is significantly associated with a delay in Epigenetic Aging Acceleration (EAA) (P < 0.05). Moreover, the direction of effect predicted by the gene remained consistent across RAPs outcomes and sensitivity MR Analyses. There is a lack of robust causal relationships between other walking conditions, such as walking duration and walking frequency, on EAA (P > 0.05).
Conclusion
Our evidence demonstrates that a higher usual walking pace is associated with a deceleration of the acceleration of all four classical epigenetic clocks acceleration.