bluuebunny/crossref_metadata_2025_split huggingface dataset:
Should adjuvant radiotherapy to the supraclavicular fossa be routinely given in patients with breast conservative treatment?
Authors: Wang Chun‐Wei , Kuo Wen‐Hong , Chang King‐Jen , Huang Chiun‐Sheng , Cheng Jason Chia‐Hsien 
Published: April 2007

AbstractBackgroundTo analyze the overall outcome, supraclavicular fossa (SCF) recurrence rate, and pattern of failure in breast cancer patients treated with conservative surgery and adjuvant radiotherapy excluding SCF treatment.MethodsA total of 143 patients were enrolled in the study. Ninety‐two percent of patients were stages I and II, and 8% were stage III. The median age was 44 years, and 31% of patients were ≤40 years old. Radiotherapy was delivered to the ipsilateral breast excluding the SCF.ResultsThe 5‐year overall survival rate of the cohort was 95%, and disease‐free survival rate was 91%. The cumulative incidence of SCF recurrence was 18% in patients with involved axillary nodes (N) ≥ 4, and 0.8% in patients with N < 4. The 5‐year SCF‐recurrence‐free survival in patients with N ≥ 4 and N < 4 was 80% and 99%, respectively (P < 0.001). N ≥ 4 was the only independent predictor for locoregional control (P = 0.045), disease‐free survival (P = 0.001), and overall survival (P = 0.008) in multivariate analysis.ConclusionsWomen with N ≥ 4 have a significantly higher risk of SCF recurrence and poorer survival. The SCF might be safely spared in patients with N < 4, but should be routinely included in the radiotherapy design for those with N ≥ 4. J. Surg. Oncol. 2007;96:144–150. © 2007 Wiley‐Liss, Inc.
Clinical impact of the surgical margin status in hepatectomy for solitary mass‐forming type intrahepatic cholangiocarcinoma without lymph node metastases
Authors: Shimada Kazuaki , Sano Tsuyoshi , Sakamoto Yoshihiro , Esaki Minoru , Kosuge Tomoo , Ojima Hidenori 
Published: April 2007

AbstractBackground and ObjectivesThe clinical impact of the surgical margin status in macroscopic curative hepatectomy for intrahepatic cholangiocarcinoma (ICC) has not yet been fully investigated.MethodsThe data of 57 consecutive patients with mass‐forming (MF) type ICC who underwent macroscopic curative hepatectomy during a 10‐year period were retrospectively examined, and the relationship between the surgical margin status and patient survival was analyzed.ResultsLymph node metastases were found to be independently associated with poor survival. The overall 5‐year survival rates and the median survival term in the 38 patients without lymph node metastases were 56.8% and 62 months, respectively. Among these 38 patients, the survival rate was better in the negative surgical margin group as compared with that in the positive surgical margin group. However, there was no statistically significant difference between the narrow and wide surgical margin groups.ConclusionsNegative surgical margin had a definite favorable impact on the survival of patients with a solitary ICC without lymph node metastases. Surgery should be conducted in patients without lymph node metastases even if a wide surgical margin cannot be obtained, but careful attention should be paid not to expose tumors during hepatic dissection. J. Surg. Oncol. 2007;96:160–165. © 2007 Wiley‐Liss, Inc.
Surgical management of carcinoma of the cervical esophagus
Authors: Daiko Hiroyuki , Hayashi Ryuichi , Saikawa Masahisa , Sakuraba Minoru , Yamazaki Mitsuo , Miyazaki Masakazu , Ugumori Toru , Asai Masahiro , Oyama Waichiro , Ebihara Satoshi 
Published: April 2007

AbstractObjectivesThe aim of the present study was to clarify the clinicopathological characteristics, reconstruction methods after resection, and prognosis of cervical esophageal squamous cell carcinoma.MethodsSeventy‐four with squamous cell carcinomas of the cervical esophagus not previously treated who underwent cervical esophagectomy or total esophagectomy with or without laryngectomy were retrospectively analyzed.ResultsThe operative morbidity and in‐hospital mortality rates were 34% (25 patients) and 4% (3 patients), respectively. Alimentary continuity was achieved with free jejunal transfer (50 patients), gastric pull‐up (19 patients), and other procedures (5 patients). The frequencies of postoperative complications and death did not differ between free jejunal transfer and gastric pull‐up. The overall 3‐ and 5‐year survival rates were 42% and 33%, respectively. The significant clinicopathological factors affecting survival were patient gender, high T factor, lymph node involvement, palpable cervical lymph nodes, vocal cord paralysis, lymphatic invasion, and extracapsular invasion. The pattern of first failure was most often locoregional (82%, 36 patients).ConclusionThe choice of free jejunal transfer or gastric pull‐up for reconstruction after surgical resection of cervical esophageal carcinoma depends on the degree of tumor extension. Adverse factors affecting survival should be considered when candidates for the surgery are selected. J. Surg. Oncol. 2007;96:166–172. © 2007 Wiley‐Liss, Inc.
Prognostic impact of positive lymph node ratio in gastric carcinoma
Authors: Celen Orhan , Yildirim Emin , Berberoglu Uğur 
Published: April 2007

AbstractBackground and objectivesTo evaluate the prognostic value of metastatic lymph node ratio in gastric carcinoma.MethodsOne hundred and sixty four patients who underwent D2dissection for gastric carcinoma at Ankara Oncology Hospital were reviewed retrospectively. The prognostic factors including Japanese classification, AJCC/UICC TNM classification and metastatic lymph node ratio (1–10% and >10%) were evaluated in univariate and multivariate Cox regression analysis.ResultsThe multivariate analysis showed that Borrmann classification, pN–category of AJCC/UICC classification and metastatic lymph node ratio were the most significant prognostic factors and a higher hazard ratio was obtained for metastatic lymph node ratio than pN category of AJCC/UICC classification (4.5 vs. 11.4). When the metastatic ratio groups of 1–10% and >10% were subdivided into pN1, pN2and pN3categories of the AJCC/UICC classification, there was no statistical difference between survival curves. When pN1, pN2and pN3categories of the AJCC/UICC classification were subdivided into the ratio groups of 1–10% and >10%, the survival rate of ratio group 1–10% was better than ratio group >10%.ConclusionWith its simplicity and reproducibility, metastatic lymph node ratio can be used as a reliable prognostic indicator. J. Surg. Oncol. 2007;96:95–101. © 2007 Wiley‐Liss, Inc.
Complex liver resection for a large intrahepatic cholangiocarcinoma in a Jehovah's witness: A strategy to avoid transfusion
Authors: Barakat Omar , Cooper John R. , Riggs Shirley A. , Hoef John W. , Ozaki Claire F. , Wood R. Patrick 
Published: April 2007

AbstractAlthough morbidity and mortality after liver resection have improved over the last two decades, complex liver resections still require perioperative blood transfusions. In this report, we describe the use of a combined left trisegmentectomy and caudate lobectomy, along with resection of the inferior vena cava, to treat a large intrahepatic cholangiocarcinoma in a Jehovah's Witness. To our knowledge, this is the first report of major liver resection for a large malignant tumor in this patient population. We also discuss the perioperative strategy and surgical technique we used to minimize blood loss and avoid transfusion. This approach could be a safe alternative for use in all patients with complex liver tumor, regardless of their religious beliefs, to reduce the risks and cost associated with blood transfusion. J. Surg. Oncol. 2007;96: 249–253. © 2007 Wiley‐Liss, Inc.
Combined brief psychosexual intervention after mastectomy: Effects on sexuality, body image, and psychological well‐being
Authors: Kalaitzi Chrisanthi , Papadopoulos Vassilios P , Michas Konstantinos , Vlasis Konstantinos , Skandalakis Panagiotis , Filippou Dimitris 
Published: April 2007

AbstractBackgroundMastectomy poses a severe threat to body image and sexuality, interfering with the psychological well‐being of both the patient and her partner. Although many psychotherapeutic approaches have been assessed and found effective in such patients, few studies have assessed couple or sex therapy in mastectomy patients.MethodsWe report on a structured combination of brief couples and sex therapy (CBPI) used in 20 women with in situ breast cancer and mastectomy and their partners. An equal number of mastectomy patients were used as controls.ResultsCBPI patients showed significant improvement in depression and state anxiety scores, as well as in body image, satisfaction with relationship, presumed attractiveness to their partner, orgasm frequency and communicating their desire.Discussion/ConclusionsCBPI can be used as an effective alternative to individual or group psychotherapy for mastectomy patients. J. Surg. Oncol. 2007;96: 235–240. © 2007 Wiley‐Liss, Inc.
Effect of time interval between surgery and preoperative chemoradiotherapy with 5‐fluorouracil or 5‐fluorouracil and oxaliplatin on outcomes in rectal cancer
Authors: C.M. Dolinsky , N.N. Mahmoud , R. Mick , W. Sun , R.W. Whittington , L.J. Solin , D.G. Haller , B.J. Giantonio , P.J. O'Dwyer , E.F. Rosato , R.D. Fry , J.M. Metz 
Published: April 2007

AbstractBackground and ObjectivesPreoperative chemoradiotherapy for locally advanced rectal cancer is now considered “standard of care.” However, the optimal time interval for resection after neoadjuvant therapy is unknown.MethodsBetween 11/90 and 11/04, 107 patients with rectal adenocarcinoma underwent preoperative chemo/RT at the University of Pennsylvania. Fifty‐six percent had LAR and 40% had APR. Chemotherapy consisted of 5‐FU/oxaliplatin in 28% and 5‐FU in 72% of patients. All patients received preoperative RT.ResultsA longer time interval between chemo/RT and surgery was associated with tumor downstaging (OR 1.24, P = 0.02). A longer time interval was not associated with: nodal downstaging (OR 1.00, P = 0.98); pathologic complete response (PCR) (OR 0.97, P = 0.80); likelihood of performing an LAR (OR 0.90, P = 0.47); improved disease free survival (DFS), local control, or distant control (HR 1.05, P = 0.49; HR 1.14, P = 0.22; HR 1.06, P = 0.52, respectively). The PCR rate was 34.5% in the 5‐FU/oxaliplatin/radiation group, and 13.7% in the 5‐FU/radiation group. If patients with microscopic CR were excluded, then the PCR rate for 5FU/OX was 21.4% and for 5‐FU was 12.2%.ConclusionsTime interval between surgery and chemo/RT appeared to have little effect on PCR or LAR rates. Patients receiving 5 FU/oxaliplatin/RT had a high PCR rate. A prospective randomized trial to test superiority of 5 FU/oxaliplatin is warranted. J. Surg. Oncol. 2007;96: 207–212. © 2007 Wiley‐Liss, Inc.
CLIC4, skin homeostasis and cutaneous cancer: Surprising connections
Authors: Suh Kwang S. , Malik Mariam , Shukla Anjali , Yuspa Stuart H. 
Published: April 2007

AbstractChloride intracellular channel 4 (CLIC4) is a putative chloride channel for intracellular organelles. CLIC4 has biological activities in addition to or because of its channel activity. In keratinocytes, CLIC4 resides in the mitochondria and cytoplasm, and CLIC4 gene expression is regulated by p53, TNF‐α, and c‐Myc. Cytoplasmic CLIC4 translocates to the nucleus in response to cellular stress conditions including DNA damage, metabolic inhibition, senescence, and exposure to certain trophic factors such as TNF‐α and LPS. Nuclear translocation is associated with growth arrest or apoptosis, depending on the level of expression. In the nucleus CLIC4 interacts with several nuclear proteins as demonstrated by yeast two‐hybrid screening and co‐immunoprecipitation. Nuclear CLIC4 appears to act on the TGF‐β pathway, and TGF‐β also causes CLIC4 nuclear translocation. In human and mouse cancer cell lines, CLIC4 levels are reduced, and CLIC4 is excluded from the nucleus. CLIC4 soluble or membrane‐inserted status is dependent on redox state, and redox alterations in cancer cells could underly the defect in nuclear translocation. CLIC4 is reduced and excluded from the nucleus of many human epithelial neoplasms. Paradoxically, CLIC4 is reciprocally upregulated in tumor stroma in conjunction with the expression of α‐smooth muscle actin in the fibroblast to myofibroblast transition. Overexpression of CLIC4 in cancer cells inhibits tumor growth in vivo. Conversely, overexpression of CLIC4 in tumor stromal cells stimulates tumor growth in vivo. Thus, CLIC4 participates in normal and pathological processes and may serve as a useful target for therapies in disturbances of homeostasis and neoplastic transformation. © 2007 Wiley‐Liss, Inc.
Sunlight and skin cancer: Lessons from the immune system
Authors: Ullrich Stephen E. 
Published: April 2007

AbstractThe ultraviolet (UV) radiation in sunlight induces skin cancer development. Skin cancer is the most common form of human neoplasia. Estimates suggest that in excess of 1.5 million new cases of skin cancer (www.cancer.org/statistics) will be diagnosed in the United States this year. Fortunately, because of their highly visible location, skin cancers are more rapidly diagnosed and more easily treated than other types of cancer. Be that as it may, approximately 10,000 Americans a year die from skin cancer, and the cost of treating skin cancer in the United States (both melanoma and non‐melanoma skin cancer) is estimated to be in excess of $2.9 billion a year. In addition to causing skin cancer, UV radiation is also immune suppressive. In fact, data from studies with both experimental animals and biopsy proven skin cancer patients suggest that there is an association between the immune suppressive effects of UV radiation and its carcinogenic potential. Recent studies in my laboratory have focused on understanding the initial molecular events that induce immune suppression. We made two novel observations: First UV‐induced keratinocyte‐derived platelet activating factor plays a role in the induction of immune suppression. Second, cis‐urocanic acid, a skin‐derived immunosuppressive compound mediates immune suppression by binding to serotonin receptors on target cells. Recent findings suggest that blocking the binding of these compounds to their receptors not only inhibits UV‐induced immune suppression but it also interferes with skin cancer induction. © 2007 Wiley‐Liss, Inc.
Estimating negotiator performance without preference information
Authors: Vetschera Rudolf 
Published: April 2007

AbstractIn empirical studies of negotiation support systems, it is often not possible to elicit utility functions from experimental subjects, since this would lead to undesired interventions into their behaviour. The present paper develops several methods to evaluate the performance of negotiators in multi‐issue negotiations without referring to their utility functions. Data collected in negotiation experiments with the NSS Inspire is used to empirically test the match of these measures to the performance measured by utility functions elicited from the subjects. Main results of this empirical analysis are: (1) the possibilities of outside observers to evaluate the performance of negotiators without knowing their utility functions are rather limited; (2) measures using only ordinal information perform as well as measures using cardinal information; (3) taking into account observed behaviour during negotiation does not improve the fit to utilities. These results can in part be attributed to the fact that actual behaviour observed during the negotiation is incompatible with utility functions elicited in Inspire. Copyright © 2007 John Wiley & Sons, Ltd.
Elucidation and decisional risk in a multi‐criteria decision based on a Choquet integral aggregation—a cybernetic framework
Authors: Montmain J. , Mauris G. , Akharraz A. 
Published: April 2007

AbstractThe authors are developing multi‐criteria Decision‐making support systems (DMSS) for project teams in charge of selecting a technical solution among alternatives. They propose a cybernetic framework to emphasize the link between decision‐making (DM) and knowledge management processes in such projects. These DMSSs rely on the tracking of the accompanying knowledge production of long‐term decisional processes by a collective with many actors. Based on knowledge‐production management, this paper explains how to design decisional risk evaluation, monitoring and control aids and traceability functions for strategic choices and logical argumentation. The DMSS is seen as a recommender system for the project manager. Each possible solution involved in the decision‐making process (DMP) is evaluated by means of a set of criteria. The evaluation results from an interpretation of the knowledge items in terms of satisfaction scores of the solutions according to the considered criteria. Aggregating these partial scores provides a ranking of all the possible solutions by order of preference. As criteria are sometimes interacting, the aggregation has to be based on adapted operators, i.e. Choquet integrals. Evaluating possible solutions by the knowledge contained in the knowledge base (KB) opens the way to automating the argumentation of the project team's decisions: the argumentation principle underlying this approach is based naturally on coupling a knowledge dynamical management system (KDMS) with the DMSS. The DMSS also evaluates the decisional risk that reflects the eventuality of a wrong selection due to the insufficiency of available knowledge at a given time in order to adopt a reliable solution. Decisional risk assessment corresponds to sensitivity analyses. These analyses are then exploited to control the decisional risk in time: they enable to identify the crucial information points for which additional and deeper investigations would be of great interest to improve the stability of the selection in the future.The knowledge management of a collective project is represented as a control loop: the KDMS is the actuator, the risk accompanying the decision is the controlled variable and is strongly linked to the entropy of the KB managed by the KDMS. Each of the three phases—intelligence, design, choice—of the DMP is identified to a function of the control loop: actuator, process and regulator. This cybernetic framework for decision has its origin in knowledge management activities for a great‐scale project—the EtLD project of the French Atomic Commission (CEA) that concerns the management of high‐level long‐life radioactive waste in France. Copyright © 2007 John Wiley & Sons, Ltd.
Is focal task‐specific dystonia limited to the hand and face?
Authors: Lo Steven E. , Frucht Steven J. 
Published: April 2007

AbstractFocal task‐specific dystonia (FTSD) of the hand and face have been well described; however, FTSD of the leg is exceedingly rare. We describe and demonstrate by videotape 2 patients with FTSD affecting the leg, in both cases triggered specifically by walking down steps. Walking on a level surface, up steps, and down steps backward, and sideways were normal. An interoceptive sensory trick (imagining walking in a different modality) led to temporary improvement. Our patients appear to demonstrate that task‐specificity in focal dystonia may not be limited to skilled, rehearsed actions and that FTSD may occur in an activity that is relatively automatic. © 2007 Movement Disorder Society
Geste antagonistes in idiopathic lower cranial dystonia
Authors: Lo Steven E. , Gelb Michael , Frucht Steven J. 
Published: April 2007

AbstractGeste antagonistes, or sensory tricks, are well described in focal dystonia affecting the neck, hand, and face. Improvement in dystonic movements is typically maintained while the trick is performed, but disappears when the geste ends. We investigated the phenomenological features of geste antagoniste maneuvers in 19 patients with idiopathic lower cranial dystonia who were prospectively evaluated over a period of 6 years. Of the 19, 10 were men, mean age of onset was 49.8 years, and the most commonly involved lower cranial area was the jaw (10 patients). In most patients, dystonia was task‐specific. Taking advantage of the improvement with a sensory geste, we manufactured oral appliances that mimicked the geste in 8 patients, and 3 continue to use it. © 2007 Movement Disorder Society
Dopamine levels after repetitive transcranial magnetic stimulation of motor cortex in patients with Parkinson's disease: Preliminary results
Authors: Khedr Eman M. , Rothwell John C. , Shawky Ola A. , Ahmed Mohammed A. , Foly K Nageh , Hamdy Ahmed 
Published: April 2007

AbstractBackground: Repeated sessions of repetitive transcranial magnetic stimulation (rTMS) over motor cortex have been reported to produce significant improvement of motor performance in patients with Parkinson's disease (PD). In addition, it is known that a single session of rTMS over motor cortex transiently increases DA in striatum. Here, we test whether repeated sessions of rTMS increase serum dopamine in PD patients and whether this correlates with changes in clinical rating scales. Material and Methods: Twenty untreated PD patients with moderate to severe symptoms (Hoehn & Yahr stage III–V 1967) were assessed on the Unified Parkinson's Disease Rating Scale (UPDRS), and with an enzyme immunoassay for quantitative determination of plasma dopamine before and after six daily sessions of 25 Hz rTMS with 3,000 stimuli over the right and left hand and leg motor cortex. Results: There was significant improvement in UPDRS compared with the baseline. Serum dopamine level also was significantly elevated ever the same interval. There was a significant correlation between UPDRS and serum dopamine level before and after treatment. Conclusion: Improved motor performance in PD after repeated sessions of rTMS may be related to an elevation of serum dopamine concentration. © 2007 Movement Disorder Society
Levodopa response in long‐term bilateral subthalamic stimulation for Parkinson's disease
Authors: Piboolnurak Panida , Lang Anthony E. , Lozano Andres M. , Miyasaki Janis M. , Saint‐Cyr Jean A. , Poon Yu‐Yan W. , Hutchison William D. , Dostrovsky Jonathan O. , Moro Elena 
Published: April 2007

AbstractSubthalamic nucleus deep brain stimulation (STN‐DBS) is effective in advanced Parkinson's disease (PD), but its effects on the levodopa response are unclear. We studied the levodopa response after long‐term STN‐DBS, STN‐DBS efficacy and predictive value of preoperative levodopa response to long‐term DBS benefit in 33 PD patients with bilateral STN‐DBS. Patients were assessed using the Unified Parkinson's Disease Rating Scale preoperatively (with and without medications) and postoperatively (without medications or stimulation, with only medications or stimulation, and with both medications and stimulation). Levodopa response significantly decreased postoperatively by 31.1% at 3 years and 32.3% at 5 years, possibly related to the reduction in medication requirement, direct STN stimulation effect or PD progression. STN‐DBS alone significantly improved motor scores (37.2% at 3 years and 35.1% at 5 years) and activities of daily living scores (27.1% at 3 years and 19.2% at 5 years). Anti‐PD drugs were significantly reduced by 47.9% at 3 years and 39.8% at 5 years. However, the magnitude of the preoperative response to levodopa did not predict DBS benefit at 3 and 5 years. © 2007 Movement Disorder Society