bluuebunny/crossref_metadata_2025_split huggingface dataset:
Contingency traps: the role of form in creative processes
Authors: Kukkonen Karin 
Published: April 2024

AbstractLiterary texts are already written before they get read, and they are therefore not subject to chance in the same way as encounters in everyday life. However, at the same time, these texts often manage to evoke a strong sense in readers that the events they read about could have turned out otherwise. I propose the notion of the “contingency trap” as a conceptual tool to address this theoretical challenge. This article addresses how authors deploy form in the creative process to integrate contingency in their texts and make it available to their readers in reading. Two interviews with Gwenaëlle Aubry about her essay Saint Phalle serve as the first case study, and her account is contrasted and compared with an analysis of Italo Calvino’s reflections on contingency in literary narrative with particular focus on his Il Castello dei destini incrociati (The Castle of Crossed Destinies, 1973). These authors’ insights into the creative process will then be complemented by research on cognitive processes related to literary creativity in order to sketch a more general theoretical understanding of how form works as a contingency trap.
Aqueous TPGS-750-M-mediated synthesis of pyrano[2,3-c]-pyrazoles: a sustainable and efficient approach
Authors: Cetin Adnan , Bayden Mehmet Yasin 
Published: April 2024

AbstractThe article describes a green and efficient synthesis method for pyrano[2,3-c]-pyrazoles, employing DL-alpha-tocopherol methoxypolyethylene glycol succinate solution (TPGS-750-M) as a green and biodegradable surfactant in water. The utilization of water as a reaction medium and TPGS-750-M as a surfactant obviates the necessity for organic solvents, thereby enhancing the environmental sustainability of the synthesis. The compounds synthesized using this novel method was characterized using various spectroscopic techniques, including 1H-NMR, 13C-NMR, and mass spectrometry.
Graphical abstract
Evaluation of traditional and machine learning approaches for modeling volatile fatty acid concentrations in anaerobic digestion of sludge: potential and challenges
Authors: Abubakar Umar Alfa , Lemar Gul Sanga , Bello Al-Amin Danladi , Ishaq Aliyu , Dandajeh Aliyu Adamu , Jagun Zainab Toyin , Houmsi Mohamad Rajab 
Published: April 2024

AbstractThis study evaluates models for predicting volatile fatty acid (VFA) concentrations in sludge processing, ranging from classical statistical methods (Gaussian and Surge) to diverse machine learning algorithms (MLAs) such as Decision Tree, XGBoost, CatBoost, LightGBM, Multiple linear regression (MLR), Support vector regression (SVR), AdaBoost, and GradientBoosting. Anaerobic bio-methane potential tests were carried out using domestic wastewater treatment primary and secondary sludge. The tests were monitored over 40 days for variations in pH and VFA concentrations under different experimental conditions. The data observed was compared to predictions from the Gaussian and Surge models, and the MLAs. Based on correlation analysis using basic statistics and regression, the Gaussian model appears to be a consistent performer, with high R2 values and low RMSE, favoring precision in forecasting VFA concentrations. The Surge model, on the other hand, albeit having a high R2, has high prediction errors, especially in dynamic VFA concentration settings. Among the MLAs, Decision Tree and XGBoost excel at predicting complicated patterns, albeit with overfitting issues. This study provides insights underlining the need for context-specific considerations when selecting models for accurate VFA forecasts. Real-time data monitoring and collaborative data sharing are required to improve the reliability of VFA prediction models in AD processes, opening the way for breakthroughs in environmental sustainability and bioprocessing applications.
Sozialität, Gedächtnis und Demenz: Eine soziologische Studie zum praktischen Vollzug des Erinnerns
Authors: Meier zu Verl Christian 
Published: April 2024

ZusammenfassungDieser Beitrag präsentiert eine soziologische Perspektive, die die neuropsychologische Perspektive von Demenz als individuelle Gedächtnisstörung und individuellen Wissensverlust nicht übernimmt, sondern einen eigenständigen Blick auf das Soziale der Demenz entwickelt. Dabei wird die These vertreten, dass Demenz nicht zu einem allgemeinen Verlust von Sozialität und sozialem Wissen führt, sondern dass es zu Verschiebungen von Sozialitätsformen kommt und individuelle Verluste in sozialen Interaktionen durch die Interaktionspartner:innen mit und ohne Demenz teilweise kompensiert werden können. Empirisch werden dazu unterschiedliche Interaktionen im Kontext der Pflege untersucht, in denen die Interaktionspartner:innen gemeinsam handeln, um zu erinnern. Im Detail kann nachverfolgt werden, wie Interaktionspartner:innen unter den Bedingungen einer Alzheimer-Krankheit Praktiken und Handlungen wechselseitig koordinieren und diese als lokal verfügbare Ressourcen für ihr soziales Erinnern nutzen. Mit Blick auf die Progredienz der Demenz lässt sich dabei eine Verschiebung der Sozialitätsformen vom inhaltlichen Gespräch über Erinnerungen hin zu körperlich-affektiven Formen des Erinnerns beobachten.
Immunomodulatory and antioxidant properties of Sarcophaga argyrostoma larval hemolymph: utilizing the Biomphalaria alexandrina snail as a model
Authors: Mashaal Alya , Abo Elqasem Asmaa A. , Abou El-Khashab Lina A. , El-Menyawy Hend M. , Abou El-Nour Basma M. , Abdullah Eman M. , Abdalkareem Asmaa M. , Al-gebaly Rawda A. , El-sayed Asmaa M. , Mabrok Ghada R. , Mahmoud Rawda R. , Ali Dina A. , Mohamed Alaa R. , Ali Hiba H. , Bishop Suhaylah Y. , Merai Nada M. , Abdullah Nadia M. , Shahata Tuqa M. , Mahmoud Fatma H. , Shukry Rofada H. , Fathy Esraa A. , Sadek Al-Shaimaa Mohsen 
Published: April 2024

AbstractIn recent years, there has been a growing interest in exploring novel natural sources for antioxidant and anti-inflammatory agents, driven by the need for alternative therapeutic strategies with fewer side effects. This study investigates the potential of the Biomphalaria alexandrina snail as a valuable model organism to evaluate the antioxidant and anti-inflammatory properties of Sarcophaga argyrostoma larval hemolymph. The choice of B. alexandrina snails as a model is based on its ecological relevance and physiological similarities to other organisms, supporting well-established use in ecological and physiological research, as well as it provides a valuable platform for such investigations. Ultimately, this study may open avenues for the development of innovative and sustainable therapeutic interventions rooted in the rich biodiversity of the natural world. The experimental design involves the extraction of hemolymph from S. argyrostoma larvae, followed by a comprehensive analysis of its antioxidant capacity and anti-inflammatory effects using adult snails. Various biochemical assays, including total antioxidant capacity, immunomodulatory markers and histological investigation, will be employed to assess the bioactive potential of the hemolymph. The outcomes of this research can be attributed to the identification of the anti-oxidant and anti-inflammatory effects of hemolymph. This effect was observed through the reduction of oxidative stress and proinflammatory mediators, impacting the biological activities of the snails. The study is the first to shed light on the potential benefits of S. argyrostoma larval hemolymph using an animal model, showcasing its ability to mitigate oxidative and inflammatory responses within the biological context of the snails.
Active Learning and Bayesian Optimization: A Unified Perspective to Learn with a Goal
Authors: Di Fiore Francesco , Nardelli Michela , Mainini Laura 
Published: April 2024

AbstractScience and Engineering applications are typically associated with expensive optimization problem to identify optimal design solutions and states of the system of interest. Bayesian optimization and active learning compute surrogate models through efficient adaptive sampling schemes to assist and accelerate this search task toward a given optimization goal. Both those methodologies are driven by specific infill/learning criteria which quantify the utility with respect to the set goal of evaluating the objective function for unknown combinations of optimization variables. While the two fields have seen an exponential growth in popularity in the past decades, their dualism and synergy have received relatively little attention to date. This paper discusses and formalizes the synergy between Bayesian optimization and active learning as symbiotic adaptive sampling methodologies driven by common principles. In particular, we demonstrate this unified perspective through the formalization of the analogy between the Bayesian infill criteria and active learning criteria as driving principles of both the goal-driven procedures. To support our original perspective, we propose a general classification of adaptive sampling techniques to highlight similarities and differences between the vast families of adaptive sampling, active learning, and Bayesian optimization. Accordingly, the synergy is demonstrated mapping the Bayesian infill criteria with the active learning criteria, and is formalized for searches informed by both a single information source and multiple levels of fidelity. In addition, we provide guidelines to apply those learning criteria investigating the performance of different Bayesian schemes for a variety of benchmark problems to highlight benefits and limitations over mathematical properties that characterize real-world applications.
Navigating Breast Cancer Oligometastasis and Oligoprogression: Current Landscape and Future Directions
Authors: Yoon Stephanie M. , Bazan Jose G. 
Published: April 2024

Abstract
Purpose
We examine the potential for curative approaches among metastatic breast cancer (MBC) patients by exploring the recent literature on local ablative therapies like surgery and stereotactic body radiation therapy (SBRT) in patients with oligometastatic (OM) breast cancer. We also cover therapies for MBC patients with oligoprogressive (OP) disease.

Key Findings
Surgery and SBRT have been studied for OM and OP breast cancer, mainly in retrospective or non-randomized trials. While many studies demonstrated favorable results, a cooperative study and single-institution trial found no support for surgery/SBRT in OM and OP cases, respectively.

Conclusion
While there is interest in applying local therapies to OM and OP breast cancer, the current randomized data does not back the routine use of surgery or SBRT, particularly when considering the potential for treatment-related toxicities. Future research should refine patient selection through advanced imaging and possibly explore these therapies specifically in patients with hormone receptor-positive or HER2-positive disease.
A New Strategy for a Separate Manufacture of Arabinooligosaccharides and Oligogalacturonides by Hydrothermal Treatment of Sugar Beet Pulp
Authors: Martínez-Gómez Sergio , Yáñez Remedios , Alonso José L. 
Published: April 2024

AbstractSugar beet pulp (SBP) samples were subjected to a two-step non-isothermal autohydrolysis process in order to obtain mixtures enriched in oligogalacturonides (OGalA) and arabinooligosaccharides (AOS) in separate streams. Operating at a maximum temperature of 130 °C, mixtures containing up to 30.4% oven-dry basis (o.d.b.) of OGalA with an OGalA/AOS ratio of 5.0 g/g were obtained during the first stage. Then, the treated solids were subjected to a second treatment at temperatures in the range 160–175 °C. When those solids were treated up to 175 °C, a mixture mainly made up of AOS (37.5% o.d.b.) with an AOS/OGalA ratio of 3.91 g/g was obtained as an effluent from the reactor. In order to increase their purity, both streams were then subjected to different refining steps. A product enriched in highly methylated and partially acetylated OGalA (42.5% o.d.b., degree of methylation (DM) = 69.2% mol/mol and degree of acetylation (DA) = 36.4% mol/mol), containing 17.2% o.d.b. of non-volatile non-identified compounds, was obtained by membrane filtration of the first-stage liquors, whereas a second one, mainly made up of AOS and galactooligosaccharides (GalOS) (55.0% AOS o.d.b., 13.8% GalOS o.d.b., and 13.3% non-volatile non-identified compounds, o.d.b.), was manufactured after an ion exchange treatment followed by membrane filtration of the second-stage liquors. This strategy was demonstrated to be a suitable and scalable alternative for the separate production of refined mixtures rich in OGalA or neutral pectic-oligosaccharides. Both types of products can result in different effects on the intestinal microbiota: AOS and GalOS show a significant bifidogenic effect and they could be consumed alone or combined with selected probiotic strains of Bifidobacteria for improving an unbalanced microbiota, whereas OGalA has been demonstrated to have a variety of biological properties and can promote the growing of some bacteria such as Faecalibacterium prausnitzii, a butyrate-producing microorganism underrepresented in patients with active IBD and infectious colitis.
Neuronal Mitochondrial Calcium Uniporter (MCU) Deficiency Is Neuroprotective in Hyperexcitability by Modulation of Metabolic Pathways and ROS Balance
Authors: Bierhansl Laura , Gola Lukas , Narayanan Venu , Dik Andre , Meuth Sven G. , Wiendl Heinz , Kovac Stjepana 
Published: April 2024

AbstractEpilepsy is one of the most common neurological disorders in the world. Common epileptic drugs generally affect ion channels or neurotransmitters and prevent the emergence of seizures. However, up to a third of the patients suffer from drug-resistant epilepsy, and there is an urgent need to develop new therapeutic strategies that go beyond acute antiepileptic (antiseizure) therapies towards therapeutics that also might have effects on chronic epilepsy comorbidities such as cognitive decline and depression. The mitochondrial calcium uniporter (MCU) mediates rapid mitochondrial Ca2+ transport through the inner mitochondrial membrane. Ca2+ influx is essential for mitochondrial functions, but longer elevations of intracellular Ca2+ levels are closely associated with seizure-induced neuronal damage, which are underlying mechanisms of cognitive decline and depression. Using neuronal-specific MCU knockout mice (MCU−/−ΔN), we demonstrate that neuronal MCU deficiency reduced hippocampal excitability in vivo. Furthermore, in vitro analyses of hippocampal glioneuronal cells reveal no change in total Ca2+ levels but differences in intracellular Ca2+ handling. MCU−/−ΔN reduces ROS production, declines metabolic fluxes, and consequently prevents glioneuronal cell death. This effect was also observed under pathological conditions, such as the low magnesium culture model of seizure-like activity or excitotoxic glutamate stimulation, whereby MCU−/−ΔN reduces ROS levels and suppresses Ca2+ overload seen in WT cells. This study highlights the importance of MCU at the interface of Ca2+ handling and metabolism as a mediator of stress-related mitochondrial dysfunction, which indicates the modulation of MCU as a potential target for future antiepileptogenic therapy.
The relationship between physical activity and depression in college students: the chain mediating role of mindfulness and meaning in life
Authors: Zhao Hongbo , Zhang Beier , Liu Wei , Jiang Yong 
Published: April 2024

AbstractIn order to explore the chain mediating effect of mindfulness and meaning in life between physical exercise and depression, 954 college students were investigated by physical exercise rating scale, self-rating depression questionnaire, mindfulness scale and meaning in life questionnaire. The results show that: (1) Physical exercise can significantly positively predict mindfulness and meaning in life, and significantly negatively predict depression; (2) The direct effect of physical exercise on depression of college students is not significant, but the indirect effect is significant. It can significantly predict depression of college students through the independent mediating effect of mindfulness and meaning in life, and can also significantly predict depression of college students through the chain mediating effect of mindfulness and meaning in life.
An ex vivo Approach in European Seabass Leucocytes Supports the in vitro Regulation by Postbiotics of Aip56 Gene Expression of Photobacterium damselae subsp. piscicida
Authors: Domínguez-Maqueda Marta , Espinosa-Ruíz Cristóbal , Esteban María Ángeles , Alarcón Francisco Javier , Tapia-Paniagua Silvana T. , Balebona María Carmen , Moriñigo Miguel Ángel 
Published: April 2024

AbstractShewanella putrefaciens Pdp11 (SpPdp11) is a probiotic strain assayed in aquaculture; however, its postbiotic potential is unknown. Postbiotics are bacterial metabolites, including extracellular products (ECPs) that improve host physiology and immunity. Their production and composition can be affected by different factors such as the growing conditions of the probiotics. Photobacterium damselae subsp. piscicida strain Lg 41/01 (Phdp) is one of the most important pathogens in marine aquaculture. The major virulent factor of this bacterium is the exotoxin aip56, responsible for inducing apoptosis of fish leucocytes. Viable SpPdp11 cells have been reported to increase resistance to challenges with Phdp. This work aimed to evaluate the effect of two ECPs, T2348-ECP and FM1548-ECP, obtained from SpPdp11 grown under different culture conditions that previously demonstrated to exert different degradative and non-cytotoxic activities, as well as the effect on pathogens biofilm formation. These SpPdp11-ECPs were then analyzed by their effect on the viability, phagocytosis, respiratory burst and apoptogenic activity against European sea bass leucocytes infected or not with Phdp supernatant. Both ECPs, T2348-ECP and FM1548-ECP, were not cytotoxic against leucocytes and significantly reduced their apoptosis. Phagocytosis and respiratory burst of leucocytes were significantly reduced by incubation with Phdp supernatant, and not influenced by incubation with T2348-ECP or FM1548-ECP. However, both activities were significantly increased after leucocyte incubation with combined T2348-ECP and FM1548-ECP with Phdp supernatant, compared to those incubated only with Phdp supernatant. Finally, both T2348-ECP and FM1548-ECP significantly reduced the relative in vitro expression of the Phdp aip56 encoding gene.
Pore throat distributions and movable fluid occurrences in different diagenetic facies of tight sandstone reservoirs in the Triassic Chang 6 reservoirs, Wuqi Area, Ordos Basin, China
Authors: Li Pan , Ou Yangcheng , Chen Hualin , Li Qiang , Zhao Lei , Yan Jian 
Published: April 2024

AbstractThe 6th member of the Triassic Yanchang Formation, hereafter referred to as Chang 6 reservoir, in the Wuqi area of the Ordos Basin presents formidable obstacles for efficient tight oil development. This reservoir is known for its tight lithology, strong heterogeneity, inadequate oil saturation, and abnormally low reservoir pressure, which collectively contribute to the highly differentiated mobility of tight oil within the formation. To overcome these challenges, a comprehensive understanding of the factors influencing oil mobility is essential. This study investigates the occurrence characteristics of movable fluids in different diagenetic facies and the corresponding influential factors by employing various microscopic experiments, including high-pressure mercury intrusion, constant-rate mercury intrusion, nuclear magnetic resonance test, scanning electron microscopy, pore-casted thin section analysis, and X-ray diffraction measurement. There is a weaker correlation between the pore-throat radius ratio and the movable fluid saturation in reservoirs of various diagenetic facies (R2 = 0.6104), whereas there is a stronger correlation between movable fluid saturation and throat radius (R2 = 0.9415). Among the seven types of diagenetic facies, chlorite membrane cementation-intergranular pore facies (Facies I) and chlorite and illite membrane cementation-intergranular pore facies (Facies II) have the best-developed throats and the highest coordination number. Illite cementation-intergranular pore facies (Facies III) and illite and chlorite membrane cementation-dissolution facies (Facies IV) demonstrate smaller pore-throat radii and moderate to poor reservoir connectivity. The other three facies, namely illite cementation-dissolution facies (Facies V), illite cementation facies (Facies VI), and carbonate tight cementation facies (Facies VII) exhibit underdeveloped pore structures and lower recovery rates. Pore-throat radius emerges as the principal factor influencing reservoir permeability and storage capacity. The distribution of favorable diagenetic facies is influenced by depositional environments, diagenetic processes, and microscopic pore-throat characteristics. This study significantly enhances our understanding of the differential occurrence characteristics of fluids in different diagenetic facies in the Chang 6 reservoir, providing valuable insights for future exploration and production endeavors aimed at optimizing oil recovery in tight sandstone reservoirs.
Chordoma cells possess bone-dissolving activity at the bone invasion front
Authors: Kawaai Katsuhiro , Oishi Yumiko , Kuroda Yukiko , Tamura Ryota , Toda Masahiro , Matsuo Koichi 
Published: April 2024

Abstract
Purpose
Chordomas are malignant tumors that destroy bones, compress surrounding nerve tissues and exhibit phenotypes that recapitulate notochordal differentiation in the axial skeleton. Chordomas recur frequently, as they resist radio-chemotherapy and are difficult to completely resect, leading to repeated bone destruction and local expansion via unknown mechanisms. Here, using chordoma specimens and JHC7 chordoma cells, we asked whether chordoma cells possess bone-dissolving activity.

Methods
CT imaging and histological analysis were performed to evaluate the structure and mineral density of chordoma-invaded bone and osteolytic marker expression. JHC7 cells were subjected to immunocytochemistry, imaging of cell fusion, calcium dynamics and acidic vacuoles, and bone lysis assays.

Results
In patients, we found that the skull base invaded by chordoma was highly porous, showed low mineral density and contained brachyury-positive chordoma cells and conventional osteoclasts both expressing the osteolytic markers tartrate-resistant acid phosphatase (TRAP) and collagenases. JHC7 cells expressed TRAP and cathepsin K, became multinucleated via cell-cell fusion, showed spontaneous calcium oscillation, and were partly responsive to the osteoclastogenic cytokine RANKL. JHC7 cells exhibited large acidic vacuoles, and nonregulatory bone degradation without forming actin rings. Finally, bone-derived factors, calcium ions, TGF-β1, and IGF-1 enhanced JHC7 cell proliferation.

Conclusion
In chordoma, we propose that in addition to conventional bone resorption by osteoclasts, chordoma cells possess bone-dissolving activity at the tumor-bone boundary. Furthermore, bone destruction and tumor expansion may occur in a positive feedback loop.