bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ternary Rotational Polyanion Coupling Enables Fast Li Ion Dynamics in Tetrafluoroborate Ion Doped Antiperovskite Li2OHCl Solid Electrolyte
Authors: Bian Juncao , Ling Sifan , Deng Bei , Lin Haibin , Zhao Ruo , Kong Long , Yuan Huimin , Zhu Jinlong , Han Songbai , Wang Liping , Zhang Rui‐Qin , Zhao Yusheng , Lu Zhouguang 
Published: April 2024

AbstractLi‐rich antiperovskite (LiRAP) hydroxyhalides are emerging as attractive solid electrolyte (SEs) for all‐solid‐state Li metal batteries (ASSLMBs) due to their low melting point, low cost, and ease of scaling‐up. The incorporation of rotational polyanions can reduce the activation energy and thus improve the Li ion conductivity of SEs. Herein, we propose a ternary rotational polyanion coupling strategy to fasten the Li ion conduction in tetrafluoroborate (BF4−) ion doped LiRAP Li2OHCl. Assisted by first‐principles calculation, powder X‐ray diffraction, solid‐state magnetic resonance and electrochemical impedance spectra, it is confirmed that Li ion transport in BF4− ion doped Li2OHCl is strongly associated with the rotational coupling among OH−, BF4− and Li2−O−H octahedrons, which enhances the Li ion conductivity for more than 1.8 times with the activation energy lowering 0.03 eV. This work provides a new perspective to design high‐performance superionic conductors with multi‐polyanions.
Anion‐Coordination Foldamer‐Based Polymer Network: from Molecular Spring to Elastomer
Authors: Qin Jiangping , Wang Yongming , Wang Tian , Wang Na , Xu Wenhua , Cheng Lin , Yu Wei , Yan Xuzhou , Gao Lingyan , Zheng Bo , Wu Biao 
Published: April 2024

AbstractFoldamer is a scaled‐down version of coil spring, which can absorb and release energy by conformational change. Here, polymer networks with high density of molecular springs were developed by employing anion‐coordination‐based foldamers as the monomer. The coiling of the foldamer is controlled by oligo(urea) ligands coordinating to chloride ions; subsequently, the folding and unfolding of foldamer conformations endow the polymer network with excellent energy dissipation and toughness. The mechanical performance of the corresponding polymer networks shows a dramatic increase from P‐L2UCl (non‐folding), to P‐L4UCl (a full turn), and then to P‐L6UCl (1.5 turns), in terms of strength (2.62 MPa; 14.26 MPa; 22.93 MPa), elongation at break (70 %; 325 %; 352 %), Young's modulus (2.69 MPa; 63.61 MPa; 141.50 MPa), and toughness (1.12 MJ/m3; 21.39 MJ/m3; 49.62 MJ/m3), respectively, which is also better than those without anion centers and the non‐foldamer based counterparts. Moreover, P‐L6UCl shows enhanced strength and toughness than most of the molecular‐spring based polymer networks. Thus, an effective strategy for designing high‐performance anion‐coordination‐based materials is presented.
Fabrication of Large‐Area Multi‐Stimulus Responsive Thin Films via Interfacially Confined Irreversible Katritzky Reaction
Authors: Shu Yuanhong , Luo Yan , Wei Hexi , Peng Lingya , Liang Jingjing , Zhai Binbin , Ding Liping , Fang Yu 
Published: April 2024

AbstractFabrication of large‐area thin films through irreversible reactions remains a formidable task. This study reports a breakthrough strategy for in situ synthesis of large‐area, free‐standing, robust and multi‐stimulus responsive thin films through a catalyst‐free and irreversible Katritzky reaction at a liquid–liquid interface. The as resulted films are featured with adjustable thickness of 1–3 μm and an area up to 50 cm2. The thin films exhibit fast photo‐mechanical motions (a response time of ca 0.1 s), vapor‐mechanical motions, as well as photo‐chromic and solvato‐chromic behaviors. It was revealed that the reason behind the observable motions is proton transfer from the imine groups to the carbonyl structures within the film induced by photo‐ and/or dimethyl sulfoxide‐stimulus. In addition, the films can harvest anionic radicals and the radicals as captured can be efficiently degraded under UV light illumination. This study provides a new strategy for fabricating smart thin films via interfacially confined irreversible Katritzky reaction.
Regulating Sulfur Redox Kinetics by Coupling Photocatalysis for High‐Performance Photo‐Assisted Lithium‐Sulfur Batteries
Authors: Liu Yuhao , Wu Feng , Hu Zhengqiang , Zhang Fengling , Wang Ke , Li Li , Chen Renjie 
Published: April 2024

AbstractChallenges such as shuttle effect have hindered the commercialization of lithium‐sulfur batteries (LSBs), despite their potential as high‐energy‐density storage devices. To address these issues, we explore the integration of solar energy into LSBs, creating a photo‐assisted lithium‐sulfur battery (PA‐LSB). The PA‐LSB provides a novel and sustainable solution by coupling the photocatalytic effect to accelerate sulfur redox reactions. Herein, a perovskite quantum dot‐loaded MOF material serves as a cathode for the PA‐LSB, creating built‐in electric fields at the micro‐interface to extend the lifetime of photo‐generated charge carriers. The band structure of the composite material aligns well with the electrochemical reaction potential of lithium‐sulfur, enabling precise regulation of polysulfides in the cathode of the PA‐LSB system. This is attributed to the selective catalysis of the liquid‐solid reaction stage in the lithium‐sulfur electrochemical process by photocatalysis. These contribute to the outstanding performance of PA‐LSBs, particularly demonstrating a remarkably high reversible capacity of 679 mAh g−1 at 5 C, maintaining stable cycling for 1500 cycles with the capacity decay rate of 0.022 % per cycle. Additionally, the photo‐charging capability of the PA‐LSB holds the potential to compensate for non‐electric energy losses during the energy storage process, contributing to the development of lossless energy storage devices.
Ethylenedioxythiophene‐Based Small Molecular Donor with Multiple Conformation Locks for Organic Solar Cells with Efficiency of 19.3 %
Authors: Xie Qian , Deng Xiangmeng , Zhao Chaowei , Fang Jie , Xia Dongdong , Zhang Yuefeng , Ding Feng , Wang Jiali , Li Mengdi , Zhang Zhou , Xiao Chengyi , Liao Xunfan , Jiang Lang , Huang Bin , Dai Runying , Li Weiwei 
Published: April 2024

AbstractTernary organic solar cells (T‐OSCs) represent an efficient strategy for enhancing the performance of OSCs. Presently, the majority of high‐performance T‐OSCs incorporates well‐established Y‐acceptors or donor polymers as the third component. In this study, a novel class of conjugated small molecules has been introduced as the third component, demonstrating exceptional photovoltaic performance in T‐OSCs. This innovative molecule comprises ethylenedioxythiophene (EDOT) bridge and 3‐ethylrhodanine as the end group, with the EDOT unit facilitating the creation of multiple conformation locks. Consequently, the EDOT‐based molecule exhibits two‐dimensional charge transport, distinguishing it from the thiophene‐bridged small molecule, which displays fewer conformation locks and provides one‐dimensional charge transport. Furthermore, the robust electron‐donating nature of EDOT imparts the small molecule with cascade energy levels relative to the electron donor and acceptor. As a result, OSCs incorporating the EDOT‐based small molecule as the third component demonstrate enhanced mobilities, yielding a remarkable efficiency of 19.3 %, surpassing the efficiency of 18.7 % observed for OSCs incorporating thiophene‐based small molecule as the third component. The investigations in this study underscore the excellence of EDOT as a building block for constructing conjugated materials with multiple conformation locks and high charge carrier mobilities, thereby contributing to elevated photovoltaic performance in OSCs.
Photoswitching Reagent for Super‐Resolution Fluorescence Microscopy
Authors: Go Ga‐eun , Jeong Uidon , Park Hyunbum , Go Seokran , Kim Doory 
Published: April 2024

AbstractSingle‐molecule localization microscopy (SMLM) has revolutionized optical microscopy by exceeding the diffraction limit and revealing previously unattainable nanoscale details of cellular structures and molecular dynamics. This super‐resolution imaging capability relies on fluorophore photoswitching, which is crucial for optimizing the imaging conditions and accurately determining the fluorophore positions. To understand the general on and off photoswitching mechanisms of single dye molecules, various photoswitching reagents were evaluated. Systematic measurement of the single‐molecule‐level fluorescence on and off rates (kon and koff) in the presence of various photoswitching reagents and theoretical calculation of the structure of the photoswitching reagent‐fluorophore pair indicated that the switch‐off mechanism is mainly determined by the nucleophilicity of the photoswitching reagent, and the switch‐on mechanism is a two‐photon‐induced dissociation process, which is related to the power of the illuminating laser and bond dissociation energy of this pair. This study contributes to a broader understanding of the molecular photoswitching mechanism in SMLM imaging and provides a basis for designing improved photoswitching reagents with potential applications extending to materials science and chemistry.
Biobased and biodegradable imine vitrimers from epoxidized soybean oil as packaging
Authors: Safarpour Milad , Zych Arkadiusz , Najafi Maedeh , Tedeschi Giacomo , Ceseracciu Luca , Marini Lara , Perotto Giovanni , Athanassiou Athanassia 
Published: April 2024

AbstractA flexible and stretchable vitrimer was synthesized using exclusively biobased building blocks and following green chemistry principles. Epoxidized soybean oil (ESO), vanillin, the biobased diamine, Priamine®, and oleic acid were used to create a material that can replace fossil‐derived, non‐biodegradable packaging. Vanillin and Priamine® were used to develop a crosslinker that could react with the epoxide groups of ESO without the need for solvents, with a catalyst‐free synthesis that does not generate any waste or byproducts. Oleic acid was incorporated, to tune the properties of the final material, since it can react with ESO and control the crosslink density. The vitrimers produced in this work showed excellent reprocessability and recyclability. They possess the ability to be molded, and they can also strongly adhere on surfaces. Moreover, they exhibited oxygen and water vapor barrier comparable to low density polyethylene, while showing very low migration into food simulant, which position them as a promising material for flexible food and general packaging market. The vitrimers showed also the capability of biodegradation in seawater, providing a safe end of life in case of mismanagement.
Perceptions regarding the recreational cobia fishery in relation to manta ray conservation
Authors: Braun Raquel , Wester Julia , Macdonald Catherine , Pate Jessica H. 
Published: April 2024

Abstract

Understanding fisheries requires not only traditional modelling approaches but also the incorporation of local ecological knowledge (LEK) which can provide other types of essential contextualizing knowledge.
Recreational anglers within the cobia fishery on the east coast of central and northern Florida target cobia by seeking out the manta rays cobia often follow and associate with, and casting at or near them. Results suggest this fishery poses a threat of entanglement, injury and disturbance to mantas in the region, especially associated with the practices and behaviours of inexperienced anglers.
Expert angler responses in interviews described changes in manta and cobia habitat use and reductions in cobia abundance
Experienced anglers pointed to social media as a key driver of the expansion of this fishery and as an explanation for their perception of the growing presence of novice anglers engaged in these practices. Respondents proposed best practices and potential management interventions and generally supported conservation action, including through willingness to engage with researchers and support management and enforcement measures related to the fishery.
Identification of Suitable Mesh Size of Commercial Stainless‐Steel for Electrochemical Oxygen Evolution Reaction
Authors: Hardianto Yuda Prima , Aziz Md. Abdul , Mohamed Mostafa M. , Yamani Zain H. 
Published: April 2024

AbstractThe study examines the oxygen evolution reaction (OER) electrocatalytic efficiency of various stainless‐steel mesh (SSM) sizes in electrolytic cells. Stainless steel is chosen due to its widespread availability and stability, making it an economically viable option. The primary objective of this investigation is to determine the optimal stainless‐steel mesh size among those currently widely available on the market. The classification of stainless‐steel mesh sizes as SS304 is confirmed by the minimal compositional variations observed across all mesh sizes through electron dispersive X‐ray (EDX) spectra and X‐ray fluorescence (XRF) analyses. Remarkably, CV experiments carried out at different scan rates indicate that SSM 200 has the maximum specific electrochemical surface area (ECSA). As a result, SSM 200 demonstrates superior performance in terms of current density response and shows the lowest overpotential in the alkaline medium compared to other stainless‐steel mesh sizes. Furthermore, the SSM 200 exhibits a low overpotential of 337 mV at a current density of 10 mA/cm2 and a Tafel slope of 62.2 mV/decade, surpassing the performance of several previously reported electrodes for the OER. Stability tests conducted under constant voltage further confirm the remarkable stability of SSM 200, making it an ideal anode for electrolytic cell applications. These findings emphasize the cost‐effectiveness and high stability of SSM 200, presenting intriguing possibilities for future research and advancements in this field.
Stabilization of coupled delayed nonlinear time fractional reaction diffusion systems using sampled‐in‐space sensing and actuation
Authors: Chen Tiane , Chen Juan , Zhuang Bo 
Published: April 2024

AbstractThis paper is considered with the asymptotic stabilization of coupled delayed nonlinear time fractional reaction diffusion systems (FRDSs) governed by fractional parabolic partial differential equations (PDEs) with space‐dependent coefficients under sampled‐data in space control. It is assumed that state measurements can be averaged measurements (AMs) or point measurements (PMs), and a finite number of sensing and actuation devices are located in a spaced manner along the spatial domain of the interest. With the proposed sampled‐data in space controller, the closed‐loop
stability is obtained. Tuning rules of system parameters and control parameters are derived using the fractional Halanay's inequality and the fractional Lyapunov method. Subsequently, the dual problem of observer design is formulated. Fractional examples are used to valid the theoretical result. Discussions on the extension of sampled‐data boundary feedback stabilization are provided finally.
Fluid shear force and hydrostatic pressure jointly promote osteogenic differentiation of BMSCs by activating YAP1 and NFAT2
Authors: Zhou Yi , Guo Pan , Jin Ziyang , Chai Miaomiao , Zhang Shuhong , Wang Xianwei , Tan Wen‐Song , Zhou Yan 
Published: April 2024

AbstractNatural bone tissue features a complex mechanical environment, with cells responding to diverse mechanical stimuli, including fluid shear stress (FSS) and hydrostatic pressure (HP). However, current in vitro experiments commonly employ a singular mechanical stimulus to simulate the mechanical environment in vivo. The understanding of the combined effects and mechanisms of multiple mechanical stimuli remains limited. Hence, this study constructed a mechanical stimulation device capable of simultaneously applying FSS and HP to cells. This study investigated the impact of FSS and HP on the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and examined the distinctions and interactions between the two mechanisms. The results demonstrated that both FSS and HP individually enhanced the osteogenic differentiation of BMSCs, with a more pronounced effect observed through their combined application. BMSCs responded to external FSS and HP stimulation through the integrin‐cytoskeleton and Piezo1 ion channel respectively. This led to the activation of downstream biochemical signals, resulting in the dephosphorylation and nuclear translocation of the intracellular transcription factors Yes Associated Protein 1 (YAP1) and nuclear factor of activated T cells 2 (NFAT2). Activated YAP1 could bind to NFAT2 to enhance transcriptional activity, thereby promoting osteogenic differentiation of BMSCs more effectively. This study highlights the significance of composite mechanical stimulation in BMSCs' osteogenic differentiation, offering guidance for establishing a complex mechanical environment for in vitro functional bone tissue construction.
Pediatric traumatic brain injury and early age multiple sclerosis in Finland: A nationwide register‐based cohort study
Authors: Laaksonen Juho , Ponkilainen Ville , Kuitunen Ilari , Möttönen Julius , Mattila Ville M. 
Published: April 2024

AbstractObjectiveExamine the link between pediatric traumatic brain injury (pTBI) and early‐onset multiple sclerosis in Finland.MethodsConducted nationwide register study (1998−2018) with 28,750 pTBI patients (< 18) and 38,399 pediatric references with extremity fractures. Multiple sclerosis diagnoses from Finnish Social Insurance Institution. Employed Kaplan−Meier and multivariable Cox regression for probability assessment, results presented with 95% CI.ResultsOf 66 post‐traumatic multiple sclerosis cases, 30 (0.10%) had pTBI, and 36 (0.09%) were in the reference group. Cumulative incidence rates (CIR) in the first 10 years were 46.5 per 100,000 (pTBI) and 33.1 per 100,000 (reference). Hazard ratio (HR) for pTBI was 1.10 (95% CI: 0.56−1.48).Stratified by gender, women's CIR was 197.9 per 100,000 (pTBI) and 167.0 per 100,000 (reference) after 15 years. For men, CIR was 44.6 per 100,000 (pTBI) and 34.7 per 100,000 (reference). In the initial 3 years, HR for female pTBI was 1.75 (95% CI: 0.05−6.32), and between years 3 and 20, it was 1.08 (95% CI: 0.51−1.67). For male patients, HR was 1.74 (95% CI: 0.69−4.39).SignificanceWe did not find evidence of an association between pTBI and early‐onset multiple sclerosis 20 years post‐initial trauma.
MAPK4 facilitates angiogenesis by inhibiting the ERK pathway in non‐small cell lung cancer
Authors: Chen Jing , Yang Jing , Liu Yufang , Zhao Xu , Zhao Juanjuan , Tang Lin , Guo Mengmeng , Zhou Ya , Chen Chao , Li Dongmei , Wen Zhenke , Liang Guiyou , Xu Lin 
Published: April 2024

AbstractBackgroundAngiogenesis plays an important role in the occurrence and development of non‐small cell lung cancer (NSCLC). The atypical mitogen‐activated protein kinase 4 (MAPK4) has been shown to be involved in the pathogenesis of various diseases. However, the potential role of MAPK4 in the tumor angiogenesis of NSCLC remains unclear.MethodsAdult male C57BL/6 wild‐type mice were randomly divided into the control group and p‐siMAPK4 intervention group, respectively. The cell proliferation was analyzed with flow cytometry and immunofluorescence staining. The vascular density in tumor mass was analyzed by immunofluorescence staining. The expressions of MAPK4 and related signaling molecules were detected by western blot analysis and immunofluorescence staining, and so on.ResultsWe found that the expression of MAPK4, which was dominantly expressed in local endothelial cells (ECs), was correlated with tumor angiogenesis of NSCLC. Furthermore, MAPK4 silencing inhibited the proliferation and migration abilities of human umbilical vein ECs (HUVECs). Global gene analysis showed that MAPK4 silencing altered the expression of multiple genes related to cell cycle and angiogenesis pathways, and that MAPK4 silencing increased transduction of the extracellular regulated protein kinases 1/2 (ERK1/2) pathway but not Akt and c‐Jun n‐terminal kinase pathways. Further analysis showed that MAPK4 silencing inhibited the proliferation and migration abilities of HUVECs cultured in tumor cell supernatant, which was accompanied with increased transduction of the ERK1/2 pathway. Clinical data analysis suggested that the higher expression of MAPK4 and CD34 were associated with poor prognosis of patients with NSCLC. Targeted silencing of MAPK4 in ECs using small interfering RNA driven by the CD34 promoter effectively inhibited tumor angiogenesis and growth of NSCLC in vivo.ConclusionOur results reveal that MAPK4 plays an important role in the angiogenesis and development of NSCLC. MAPK4 may thus represent a new target for NSCLC.
Identifying Potential SOS1 Inhibitors via Virtual Screening of Multiple Small Molecule Libraries against KRAS‐SOS1 Interaction
Authors: Ikram Saima , Sayyah Ehsan , Durdağı Serdar 
Published: April 2024

AbstractThe RAS‐MAPK signaling pathway, crucial for cell proliferation and differentiation, involves key proteins KRAS and SOS1. Mutations in the KRAS and SOS1 genes are implicated in various cancer types, including pancreatic, lung, and juvenile myelomonocytic leukemia. There is considerable interest in identifying inhibitors targeting KRAS and SOS1 to explore potential therapeutic strategies for cancer treatment. In this study, advanced in silico techniques were employed to screen small molecule libraries at this interface, leading to the identification of promising lead compounds as potential SOS1 inhibitors. Comparative analysis of the average binding free energies of these predicted potent compounds with known SOS1 small molecule inhibitors revealed that the identified compounds display similar or even superior predicted binding affinities compared to the known inhibitors. These findings offer valuable insights into the potential of these compounds as candidates for further development as effective anti‐cancer agents.
Monomeric Far‐red and Near‐infrared Fluorescent Biliproteins of Ultrahigh Brightness
Authors: Jiang Xiang‐Xiang , Hou Ya‐Nan , Lu Li‐Wen , Zhao Kai‐Hong 
Published: April 2024

AbstractFar‐red and near‐infrared fluorescent proteins have regions of maximum transmission in most tissues and can be widely used as fluorescent biomarkers. We report that fluorescent phycobiliproteins originating from the phycobilisome core subunit ApcF2 can covalently bind biliverdin, named BDFPs. To further improve BDFPs, we conducted a series of studies. Firstly, we mutated K53Q and T144A of BDFPs to increase their effective brightness up to 190 % in vivo. Secondly, by homochromatic tandem fusion of high‐brightness BDFPs to achieve monomerization, which increases the effective brightness by up to 180 % in vivo, and can effectively improve the labeling effect. By combining the above two approaches, the brightness of the tandem BDFPs was much improved compared with that of the previously reported fluorescent proteins in a similar spectral range. The tandem BDFPs were expressed stably while maintaining fluorescence in mammalian cells and Caenorhabditis elegans. They were also photostable and resistant to high temperature, low pH, and chemical denaturation. The tandem BDFPs advantages were proved in applications as biomarkers for imaging in super‐resolution microscopy.