bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exercise promotes osteogenic differentiation by activating the long non-coding RNA H19/microRNA-149 axis
Authors: Zhou Xu-Chang , Wang Dong-Xue , Zhang Chun-Yu , Yang Ya-Jing , Zhao Ruo-Bing , Liu Sheng-Yao , Ni Guo-Xin 
Published: April 2024

BACKGROUND
Regular physical activity during childhood and adolescence is beneficial to bone development, as evidenced by the ability to increase bone density and peak bone mass by promoting bone formation.
AIM
To investigate the effects of exercise on bone formation in growing mice and to investigate the underlying mechanisms.
METHODS
20 growing mice were randomly divided into two groups: Con group (control group, n = 10) and Ex group (treadmill exercise group, n = 10). Hematoxylin-eosin staining, immunohistochemistry, and micro-CT scanning were used to assess the bone formation-related indexes of the mouse femur. Bioinformatics analysis was used to find potential miRNAs targets of long non-coding RNA H19 (lncRNA H19). RT-qPCR and Western Blot were used to confirm potential miRNA target genes of lncRNA H19 and the role of lncRNA H19 in promoting osteogenic differentiation.
RESULTS
Compared with the Con group, the expression of bone morphogenetic protein 2 was also significantly increased. The micro-CT results showed that 8 wk moderate-intensity treadmill exercise significantly increased bone mineral density, bone volume fraction, and the number of trabeculae, and decreased trabecular segregation in the femur of mice. Inhibition of lncRNA H19 significantly upregulated the expression of miR-149 and suppressed the expression of markers of osteogenic differentiation. In addition, knockdown of lncRNA H19 significantly downregulated the expression of autophagy markers, which is consistent with the results of autophagy-related protein changes detected in mouse femurs by immunofluorescence.
CONCLUSION
Appropriate treadmill exercise can effectively stimulate bone formation and promote the increase of bone density and bone volume in growing mice, thus enhancing the peak bone mass of mice. The lncRNA H19/miR-149 axis plays an important regulatory role in osteogenic differentiation.
Different Assessment Methods in a Civil Engineering Course
Authors: Hellum Vidar 
Published: April 2024

Due to the outbreak of Covid-19, there has been a need for exploring different assessment methods and approaches to teaching. The purpose of the present paper is to share the experiences and discuss three different assessment methods that have been used in the same university course within civil engineering studies over the last three years. The three assessment methods which have been explored are (i) a conventional four-hour unseen exam with calculation tasks performed at the campus, (ii) a 24-hour home exam with calculation tasks and (iii) a portfolio-based assessment with an additional oral exam.
The choice of assessment method clearly influenced the grades where the portfolio-based assessment with the additional oral exam produced more than a grade higher average than the two other assessment methods. Interestingly, there were no indications of gender differences between the assessment methods. Females and males achieved similar average grades in all the introduced modes of assessments.
Based on comparisons between the portfolio results and the following oral exam there are indications that the improved grades were not only a function of an “easier assessment method” but might also be because of better performance which may partly be induced by the mode of assessment.
O LÓGICO-HISTÓRICO NA ORGANIZAÇÃO DO ENSINO: UMA SITUAÇÃO DESENCADEADORA DA APRENDIZAGEM ACERCA DO CONCEITO DE FUNÇÃO
Authors: Silva Maria Marta da , Silvestre Bruno Silva 
Published: April 2024

O artigo apresenta-se na temática da formação inicial de professores de matemática na perspectiva de organizar um ensino capaz de superar a racionalidade técnica por meio do movimento lógico-histórico dos conceitos. Nessa perspectiva, apresenta-se como questão de pesquisa: quais os indícios elucidados por um coletivo de professores de Matemática em formação acerca da apropriação do conceito de função, a partir do desenvolvimento de uma Situação Desencadeadora da Aprendizagem (SDA)abalizada no movimento lógico-histórico? Conexo à questão, tem-se o objetivo de: investigar os indícios dados por um coletivo de professores de Matemática em formação acerca da apropriação do conceito de função, a qual está alicerçada numa proposta de organização do ensino e aprendizagem desse conceito, firmada a partir do desenvolvimento de uma situação desencadeadora de aprendizagem fundamentada no movimento lógico-histórico. A metodologia de pesquisa se desenvolve por meio de um experimento formativo que teve como foco o desenvolvimento de uma SDA que foi planejada durante a disciplina: Organização do ensino dos conceitos matemáticos a partir dos pressupostos da teoria histórico cultural. A referida disciplina fazia parte da matriz curricular de uma Especialização Lato Sensu sediada na mesma Instituição de Ensino Superior onde se encontrava a turma de Pré-Cálculo da licenciatura em Matemática, que teve seus trinta alunos como sujeitos de pesquisa durante o desenvolvimento da SDA. Uma das tarefas propostas nessa disciplina era que os grupos de alunos elaborassem uma SDA que abordasse um conceito matemático. Um dos grupos organizou uma SDA no formato de uma história virtual denominada ‘O Código de Turake’, sendo que a mesma abordava o conceito de função. Todo o desenvolvimento da SDA foi registrado de forma audiovisual e, posteriormente, serviu para montarmos nossa estrutura de análise que foi composta de unidade, cenas e flashes. A análise dos dados dá indícios de que a organização do ensino de conceitos matemáticos que valoriza o movimento lógico-histórico pode aportar-se teórico-metodologicamente na propositura de SDAs, as quais possuam em seu seio a essência do conceito. Também mostra sinais de que os sujeitos admitem a lógica do conceito em unidade com a produção histórico-humana desse conhecimento, onde a unidade lógico-histórica possibilitou compreender o processo de construção do conceito de função a partir de sua estrutura interna.
UMA PROPOSTA DE SEQUÊNCIA DE ENSINO INVESTIGATIVA PARA O ENSINO DE ELETRODINÂMICA
Authors: Da Silva Fernanda Batista , Denardin Luciano 
Published: April 2024

Este trabalho tem como objetivo propor uma Sequência de Ensino Investigativa sobre Eletrodinâmica, com vistas a promover a alfabetização científica em estudantes do Ensino Médio. As atividades foram elaboradas a partir dos elementos do Ensino por Investigação proposto por Carvalho (2013) e nos eixos estruturantes e indicadores de alfabetização científica apresentado por Sasseron (2008). Foram elaboradas 24 atividades sobre os tópicos: aparelhos elétricos, energia elétrica, plugues e tomadas, entre outros assuntos. As atividades foram divididas em três blocos, contemplando todos os eixos estruturantes da alfabetização científica propostos por Sasseron (2008). Em conclusão, são inúmeras as possibilidades de trabalhar com o ensino por investigação, desde que o estudante seja protagonista do aprendizado e construa conhecimento científico a partir da reflexão e argumentação feitas com base nos dados e evidências obtidos ao investigar uma situação-problema.
Long-term solar radiation forecasting based on LSTM and attention mechanism: a case study in Algeria
Authors: Teta Ali , Medkour Maissa , Rabehi Abdelaziz , Korich Belkacem , Bakria Derradji 
Published: April 2024

The growing adoption of photovoltaic (PV) energy in urban areas underscores its capability to meet energy demands effectively. The accurate forecasting of meteorological parameters, particularly global solar radiation, is paramount for the efficient management and utilization of solar energy resources. Solar radiation forecasting methods typically fall into two main categories: cloud imagery combined with physical approaches, and Artificial Intelligence (AI) based methods. Due to the non-stationary nature of solar radiation and the high nonlinearity of atmospheric conditions, conventional forecasting approaches often exhibit poor accuracy. Artificial intelligence based approaches, such as machine learning and deep learning algorithms, are extensively employed in global solar radiation forecasting research, demonstrating impressive accuracy. In this respect, this paper presents a novel approach for long term monthly forecasting of global solar radiation using a Bidirectional Long Short-Term Memory (LSTM) architecture augmented with an attention mechanism that includes a Squeeze and Excitation (SE) block (SE-BiLSTM). The effectiveness of this model is extensively evaluated for long-term monthly solar radiation forecasting using meteorological data collected over a 20-year period (from Jan 2001 to Dec 2020) from the National Aeronautics and Space Administration (NASA). The proposed SE-BiLSTM model is compared with well-established forecasting models including Naïve, Autoregressive Moving Average (ARMA), Multi-layer Perceptron (MLP), LSTM, and Bidirectional LSTM. Through rigorous simulation tests, our model demonstrates superior performance, achieving the lowest mean absolute percentage error (MAPE) of 4.52% and mean absolute error (MAE) of 7.89 kW/m2. This advancement holds significant promise for enhancing solar energy forecasting accuracy and its practical application in renewable energy systems.
Risk Factors Associated with Thromboembolic Complications After total Hip Arthroplasty: An Analysis of 1,129 Pulmonary Emboli
Authors: Liu Kevin C. , Bagrodia Neelesh , Richardson Mary K. , Piple Amit S. , Kusnezov Nicholas , Wang Jennifer C. , Lieberman Jay R. , Heckmann Nathanael D. 
Published: April 2024

Introduction:
Venous thromboembolism (VTE) remains a dangerous complication after total hip arthroplasty (THA), despite advances in chemoprophylactic measures. This study aimed to identify risk factors of developing pulmonary embolism (PE) and deep vein thrombosis (DVT) after THA using a modern cohort of patients reflecting contemporary practices.

Methods:
The Premier Healthcare Database was queried for primary, elective THAs from January 1st, 2015, to December 31st, 2021. Patients who developed PE or DVT within 90 days of THA were compared with patients who did not develop any postoperative VTE. Differences in patient demographics, comorbidities, hospital factors, perioperative medications, chemoprophylactic agents, and allogeneic blood transfusion were compared between cohorts. Multivariable logistic regression models were used to identify independent risk factors of PE and DVT. In total, 544,298 THAs were identified, of which 1,129 (0.21%) developed a PE and 1,799 (0.33%) developed a DVT.

Results:
Patients diagnosed with a PE had significantly higher rates of in-hospital death (2.6% vs 0.1%, P < 0.001) compared with those without a PE. Age (adjusted odds ratio: 1.02 per year, 95% confidence interval [CI]: 1.01 to 1.03) and Black race (aOR: 1.52, 95% CI: 1.24 to 1.87) were associated with an increased risk of PE. Comorbidities associated with increased risk of PE included chronic pulmonary disease (aOR: 1.58, 95% CI: 1.36 to 1.84), pulmonary hypertension (aOR: 2.06, 95% CI: 1.39 to 3.04), and history of VTE (aOR: 2.38, 95% CI: 1.98 to 2.86). Allogeneic blood transfusion (aOR: 2.40, 95% CI: 1.88 to 3.06) was also associated with an increased risk of PE while dexamethasone utilization was associated with a reduced risk (aOR: 0.83, 95% CI: 0.73 to 0.95).

Discussion:
Increasing age; Black race; allogeneic blood transfusion; and comorbidities, including chronic pulmonary disease, pulmonary hypertension, and history of VTE, were independent risk factors of PE after THA. Given the increased mortality associated with PE, patients should be carefully evaluated for these factors and managed with an appropriate chemoprophylactic regimen.
Pernyataan Iman Menurut Roma 10:9 dan Relevansinya bagi Kaum Difabel Kategori Tunawicara
Authors: Wicaksono Arif , Sumisu Laurens Ruben 
Published: April 2024

The statement of faith according to Romans 10:9 is a call to confess Jesus Christ as Lord and accept His resurrection from the dead. This verse emphasizes the importance of verbal confession of the Christian faith and belief in the heart in the truth of Christ's resurrection as the basis for salvation. For disabled people in the speech category, who may face communication challenges. In order to find the relevance of this confession of faith to the faith of the Speech Impaired, the author uses a literature study approach. Based on research conducted, confession does not always have to be verbal. Confession of faith can be done in a deep heart and awareness of the universal gift of salvation, not limited by communication limitations. The relevance of Romans 10:9 for the deaf category lies in their ability to experience, express, and celebrate the Christian faith through various forms of communication, while the Church provides support and inclusivity to ensure their safety and spiritual growth.ABSTRAKPernyataan iman menurut Roma 10:9 adalah panggilan untuk mengakui Yesus Kristus sebagai Tuhan dan mempercayai kebangkitan-Nya dari antara orang mati. Ayat ini menekankan pentingnya pengakuan verbal terhadap iman Kristen dan keyakinan dalam hati akan kebenaran kebangkitan Kristus sebagai dasar keselamatan. Bagi kaum difabel kategori tunawicara, yang mungkin menghadapi tantangan komunikasi. Guna menemukan relevansi pengakuan iman ini terhadap keimanan kaum Tuna wicara penulis menggunakan pendekatan studi pustaka. Berdasarkan penelitian yang dilakukan pengakuan tidak selalu harus bersifat verbal. Pengakuan iman dapat dilakukan dalam hati yang mendalam serta kesadaran akan anugerah keselamatan yang universal, tidak terbatas oleh keterbatasan komunikasi. Relevansi Roma 10:9 bagi kaum difabel kategori tunawicara terletak pada kemampuan mereka untuk mengalami, menyatakan, dan merayakan iman Kristen melalui berbagai bentuk komunikasi, sementara gereja memberikan dukungan dan inklusivitas untuk memastikan keselamatan dan pertumbuhan rohani mereka.. Kata-kata kunci: Difabel, Pernyataan Iman, Roma 10:9, Tunawicara.
Studi Pengembangan Konseling Kristen dalam Memengaruhi Penerimaan Diri
Authors: Deak Victor , Geovani Loveilia 
Published: April 2024

This research focuses on the role of Christian Cognitive-Behavioral Therapy (C-CBT) in the self-acceptance process during young adulthood, by integrating aspects of Christian counseling and Christian identity formation. The study proposes that the integration of cognitive-behavioral principles with Christian values and teachings can offer a unique and effective approach to addressing self-acceptance issues. The research methodology employs a qualitative approach. Results indicate that C-CBT significantly contributes to improved self-acceptance, achieved through self-reflection driven by Christian values, understanding, and reinterpretation of beliefs about oneself in the light of Christian faith. It was also found that the process of Christian identity formation, reinforced through C-CBT, plays an important role in supporting self-acceptance. The integration of cognitive-behavioral and Christian counseling elements offers a valuable and effective approach in supporting self-acceptance during young adulthood. ABSTRAKPenelitian ini berfokus pada peranan terapi kognitif-perilaku Kristen (Christian Cognitive-Behavioral Therapy, C-CBT) dalam proses penerimaan diri pada masa dewasa muda, dengan mengintegrasikan aspek konseling Kristen dan formasi identitas Kristen. Kajian ini mengusulkan integrasi prinsip-prinsip kognitif-perilaku dengan nilai-nilai dan ajaran Kristen yang dapat menawarkan pendekatan unik dan efektif untuk mengatasi masalah penerimaan diri. Metodologi penelitian ini menggunakan pendekatan kualitatif. Hasil penelitian menunjukkan bahwa C-CBT secara signifikan berkontribusi terhadap peningkatan penerimaan diri, dicapai melalui refleksi diri yang didorong oleh nilai-nilai Kristen, pemahaman dan reinterpretasi keyakinan tentang diri sendiri dalam cahaya iman Kristen. Ditemukan juga bahwa proses formasi identitas Kristen, yang diperkuat melalui C-CBT, memainkan peran penting dalam mendukung penerimaan diri. Integrasi kognitif-perilaku dan elemen-elemen konseling Kristen menawarkan pendekatan yang berharga dan efektif dalam mendukung penerimaan diri pada masa dewasa muda. Kata-kata kunci: Konseling Kristen; Penerimaan Diri; Pengembangan Identitas; Krisis; Emerging Adulthood
A IMPORTÂNCIA DA MONITORIA PARA APRENDIZAGEM DOS FUNDAMENTOS DA EDUCAÇÃO NO CURSO DE LICENCIATURA EM EDUCAÇÃO FÍSICA
Authors: Alves João Fillype Vasconcelos Viana , Santos Francisco Xavier dos , Lima Isael João de , Silva Liliane Farias Cabral Borges da , Barreto Magna Sales , Ferreira Monica Maria do Carmo , Silva João Lucas Ferreira Bonifacio e , Nascimento Eduarda Vitória de Melo , Santana José Daniel Barbosa de 
Published: April 2024

O programa de monitoria tem como finalidade proporcionar uma experiência enriquecedora no processo de formação, onde destaca-se a participação do aluno monitor na função de aprendiz docente, como forma de produção de saberes e experiências enriquecedoras durante o desenvolvimento do processo de ensino e aprendizagem da monitoria no curso de Licenciatura em Educação Física. O presente trabalho, trata-se de relato de experiência a partir da vivência dos discentes/monitores na disciplina de fundamentos da educação, ministrada no curso de graduação Licenciatura em Educação Física na Universidade Federal de Pernambuco no Centro Acadêmico da Vitória de Santo Antão, disciplina ofertada no 1⁰ período. Tal experiência ocorreu durante o período presencial pós-pandemia no semestre letivo 2022.1 a 2022.2 com duração de 4 meses. Sendo possível, aprofundar nos conhecimentos teóricos dos movimentos que constituíram a Educação brasileira, tais como movimento iluminista, movimento positivista e o movimento escolanovista, elencando os principais teóricos que são referência na efetivação desses movimentos e correlacionando os principais conceitos com a Educação Física escolar. Pode-se considerar neste processo de formação docente, as funções didático-pedagógicas desempenhadas pelos monitores na qual consistiu no apoio aos estudantes na disciplina, na elaboração e resolução de exercícios, em desenvolvimento de projetos didáticos acadêmicos, produção de seminários, compreensão da bibliografia básica da disciplina, orientação quanto às dúvidas dos conteúdos ministrados em sala de aula e ainda, em situações na qual o professor orientador necessitou de auxílio. Podemos afirmar que, a experiência da monitoria possibilitou um desenvolvimento de habilidades de pesquisa, de produção acadêmica de trabalhos para eventos e discussões sobre conceitos importantes tais como Ensino, Educação e Aprendizagem e prática pedagógica refletindo a partir das conexões os conceitos e relação teoria e prática para compreensão de uma sociedade sábia a partir de questionamentos teóricos, didáticos e educativos, contribuindo na constituição de profissionalização docente dos monitores.
ĐÁNH GIÁ NGUY CƠ NGÃ Ở NGƯỜI BỆNH CAO TUỔI SAU ĐỘT QUỴ
Authors: Nguyễn Thị Thu Hương , Nguyễn Ngọc Tâm , Trần Viết Lực 
Published: April 2024

Mục tiêu: đánh giá nguy cơ ngã và một số yếu tố liên quan trên người bệnh cao tuổi sau đột quỵ. Đối tượng và phương pháp: Nghiên cứu mô tả cắt ngang trên 107 người bệnh ³ 60 tuổi được chẩn đoán đột quỵ não khám và điều trị tại Bệnh viện Lão Khoa Trung ương từ tháng 07-11/2021. Nguy cơ ngã được đánh giá bằng bảng đánh giá nguy cơ ngã 21 câu hỏi. Kết quả: Tỉ lệ người bệnh có nguy cơ ngã cao là 69,2%. Tỉ lệ nguy cơ ngã cao ở nam là 70,4% và ở nữ là 67,9%. Tuổi càng cao thì nguy cơ ngã càng cao. Tuổi trung bình của nhóm nguy cơ ngã cao cao hơn có ý nghĩa thống kê so với ở nhóm nguy cơ ngã thấp. Triệu chứng liệt nửa người, đột quỵ nhồi máu não và mức độ di chứng sau đột quỵ càng nặng có mối liên quan có ý nghĩa thống kê với nguy cơ ngã (p<0,05). Không có sự khác biệt có ý nghĩa thống kê giữa nguy cơ ngã và giới, chỉ số khối cơ thể, một số bệnh đồng mắc, số lần đột quỵ và thời gian chẩn đoán đột quỵ não. Kết luận: cứ hai trong ba người bệnh cao tuổi sau đột quỵ có nguy cơ ngã cao. Nguy cơ ngã có mối liên quan với tuổi cao, triệu chứng liệt nửa người, đột quỵ nhồi máu não và mức độ di chứng sau đột quỵ.
TÌNH TRẠNG RỐI LOẠN GIẤC NGỦ VÀ ĐẶC ĐIỂM LÃO KHOA TRÊN NGƯỜI BỆNH SAU ĐỘT QUỴ
Authors: Nguyễn Thị Hoài Thu , Nguyễn Ngọc Tâm , Hoàng Cúc , Trần Viết Lực 
Published: April 2024

Mục tiêu: Đánh giá tình trạng rối loạn giấc ngủ và các đặc điểm lão khoa trên người bệnh cao tuổi sau đột quỵ.
Phương pháp nghiên cứu: Nghiên cứu mô tả cắt ngang thực hiện trên người cao tuổi sau đột quỵ tại bệnh viện Lão khoa Trung ương. Chúng tôi sử dụng thang điểm The Pittsburgh Sleep Quality Index (PSQI) để đánh giá tình trạng rối loạn giấc ngủ. Đặc điểm lão khoa bao gồm hoạt động hàng ngày, tình trạng dinh dưỡng, mệt mỏi, đa bệnh lý và trầm cảm. Nghiên cứu sử dụng SPSS 22.0 để phân tích số liệu.
Kết quả: Tổng số 138 bệnh nhân trong nghiên cứu với độ tuổi trung bình là 74,59 (độ lệch chuẩn là 8,45). Tỉ lệ rối loạn giấc ngủ là 75,4%. Tỉ lệ bệnh nhân phụ thuộc là 82,6% với 114 người. Nhóm có nguy cơ suy dinh dưỡng là 60 bệnh nhân với 43,5%. Bệnh nhân có từ 5 bệnh lý trở lên chiếm 30,4%. Điểm trung bình của mệt mỏi là 4,73±1,66.
Kết luận: Tỉ lệ rối loạn giấc ngủ trên người bệnh sau đột quỵ khá cao. Cần sàng lọc rối loạn giấc ngủ cho bệnh nhân sau đột quỵ để cải thiện chất lượng cuộc sống của đối tượng trên.
Psychiatric outcomes in outpatients affected by long COVID: A link between mental health and persistence of olfactory complaint
Authors: Metelkina-Fernandez Victoria , Dumas Louise-Emilie , Vandersteen Clair , Chirio David , Gros Auriane , Fernandez Arnaud , Askenazy Florence , Manera Valeria 
Published: April 2024

BACKGROUND
Anosmia was one of the main symptoms of coronavirus disease 2019 (COVID-19). A psychiatric history (i.e., depression) may be an independent contributor to the risk of COVID-19 diagnosis, and COVID-19 survivors appear to have an increased risk of neuropsychiatric sequelae (bidirectional association).
AIM
To compare the rate of psychiatric disorder among post-COVID patients without anosmia vs patients with persistent olfactory complaints.
METHODS
We conducted a prospective case control study from March 2020 to May 2021. Patients recruited at the ENT department of Nice University Hospital had a subjective olfactory complaint (visual analogue scale) for over 6 wk and a molecular or CT-proven severe acute respiratory syndrome coronavirus 2 diagnosis confirmed by serology. Post-COVID patients without persistent olfactory disorders were recruited at the university hospital infectiology department. Psychiatric medical histories were collected by a psychiatrist during the assessments.
RESULTS
Thirty-four patients with post-COVID-19 olfactory complaints were included in the first group of the study. Fifty percent of the patients were female (n = 17). The group’s mean age was 40.5 ± 12.9 years. The control group included 32 participants, of which 34.4% were female (n = 11), and had a mean age of 61.2 ± 12.2 years. The rate of psychiatric disorder among post-COVID patients with olfactory complaints was significatively higher (41.7%) than among patients without (18.8%) (χ 2 = 5.9, P = 0.015).
CONCLUSION
The presence of a psychiatric history may constitute a potential risk factor for the development of long COVID due to persistent anosmia. It therefore seems important to establish reinforced health monitoring after a COVID 19 infection in at-risk patients. Further prospective, translational, and collaborative studies are needed to extrapolate these results to the general population.