bluuebunny/crossref_metadata_2025_split huggingface dataset:
ARTIS Pheno®: a potential tool for cochlear implant surgery
Authors: Schmidt S. , Tisch M. , Bahr-Hamm K. , Matthias C. , Overhoff D. , Waldeck S. 
Published: April 2024

Abstract
Purpose
Cochlear implantation is a standard approach to hearing rehabilitation and encompasses three main stages: appropriate patient selection, a challenging surgical procedure, which should be as atraumatic as possible and preserve cochlear structures, and lifelong postoperative follow-up. Computed tomography (CT) is performed to assess postoperative implant position. The Siemens Advanced Radar Target Identification System (ARTIS) Pheno provides fluoroscopic imaging during surgery and has so far been mainly used by cardiologists, neurosurgeons and trauma surgeons.

Methods
Six patients with difficult anatomy or a challenging medical history were selected for a surgical procedure, during which we planned to use the ARTIS Pheno to accurately position and assess implant position under fluoroscopy during and immediately after surgery. In all six cases, the ARTIS Pheno was used directly in the surgical setting. The procedures were performed in cooperation with the neuroradiology department in an interdisciplinary manner.

Results
In all six patients, fluoroscopy was used to visualise the procedure at different stages of surgery. In five patients, the procedure was successfully completed. This approach allowed us to finally assess implant position and confirm the correct and complete insertion of the electrode while the patient was still under anaesthesia.

Conclusion
These cases showed positive surgical outcomes. Although the procedure is more complex than a standard approach, patients can be managed in a safe, effective and appropriate manner. The assessment of implant position in real time during surgery leads to greater patient and surgeon satisfaction. The approach presented here ensures a high quality of cochlear implant surgery even in difficult surgical situations and meets the requirements of modern surgery.
Omphacite breakdown: nucleation and deformation of clinopyroxene-plagioclase symplectites
Authors: Zertani Sascha , Morales Luiz F. G. , Menegon Luca 
Published: April 2024

AbstractThe breakdown of omphacite plays an important role in the exhumation and retrogression of eclogites. Additionally, metamorphic reactions associated with grain size reduction have the potential to significantly impact deformation mechanisms and the rheology of crustal rocks. We analyze the breakdown reaction omphacite → diopsidic clinopyroxene + plagioclase ± amphibole and associated microstructures by electron backscatter diffraction. The reaction results in the formation of (diopsidic) clinopyroxene-plagioclase symplectites. Samples were chosen from localities on Holsnøy (western Norway) and Lofoten (northern Norway), that are representative of vermicular symplectites, partly recrystallized symplectites, and deformed symplectites. Interphase misorientation analysis based on the electron backscatter diffraction results reveals that the nucleation of (diopsidic) clinopyroxene-plagioclase symplectites was crystallographically controlled, with the diopside copying the lattice orientation of the omphacite, and the plagioclase growing along diopside planes with favorable, i.e., similar, interplanar spacing. Deformation of the (diopsidic) clinopyroxene-plagioclase symplectites occurred by fracturing, transitioning into grain boundary sliding accommodated by diffusion creep. The results indicate that the formation of vermicular symplectites is not associated with enhanced permeability and fluid flow. Subsequent recrystallisation and grain-size sensitive deformation of the symplectites facilitates fluid redistribution and weakening of the retrogressed eclogites.
Utilization and quality of palliative care in patients with hematological and solid cancers: a population-based study
Authors: Gebel Cordula , Ditscheid Bianka , Meissner Franziska , Slotina Ekaterina , Kruschel Isabel , Marschall Ursula , Wedding Ullrich , Freytag Antje 
Published: April 2024

Abstract
Background
Palliative care (PC) contributes to improved end-of-life care for patients with hematologic malignancies (HM) and solid tumors (ST) by addressing physical and psychological symptoms and spiritual needs. Research on PC in HM vs. ST patients is fragmented and suggests less use.

Methods
We analyzed claims data of all deceased members of a large German health insurance provider for the year before death. First, we analyzed the frequency and the beginning of different types of PC and compared patients with HM vs. ST. Second, we analyzed the adjusted impact of PC use on several end-of-life quality outcomes in patients with HM vs. ST. We performed simple and multiple (logistic) regression analysis, adjusted for relevant covariates, and standardized for age and sex.

Results
Of the 222,493 deceased cancer patients from 2016 to 2020, we included 209,321 in the first analysis and 165,020 in the second analysis. Patients with HM vs. ST received PC less often (40.4 vs. 55.6%) and later (34 vs. 50 days before death). PC use significantly improved all six quality indicators for good end-of-life care. HM patients had worse rates in five of the six indicators compared with ST patients. Interaction terms revealed that patients with ST derived greater benefit from PC in five of six quality indicators than those with HM.

Conclusion
The data highlight the need to integrate PC more often, earlier, and more effectively into the care of patients with HM.
The use of interventional procedures for cancer pain. A brief review
Authors: Lee Yi-Ching , Brake Timothy , Zhao Emma , Dumitrescu Alix , Lee Wei , Tassie Benjamin , Khor Kok-Eng , Wang Andy Yi-Yang 
Published: April 2024

Abstract
Context
Pain is a common experience in people living with cancer. Concerns around opioid prescribing have seen a move toward a multi-modality management approach, which includes interventional pain procedures.

Purpose
In this paper we discuss the interventional pain procedures used to treat cancer pain at two major tertiary centers in Australia.

Methods and results
This expert review provides practical insights on cancer pain management from healthcare providers in different specialties. These insights can be used to guide the management of a wide range of cancer pain types.

Conclusions
Furthermore, this review identifies the need for a systematic and comprehensive approach to the management of cancer pain that is broader than that of a single specialty. With recent advances in pain management procedures, an interdisciplinary approach is essential in order to provide an up to date, patient tailored approach to pain management.
This review will help inform the development of a cancer pain intervention registry.
Testing for periodicity at an unknown frequency under cyclic long memory, with applications to respiratory muscle training
Authors: Beran Jan , Näscher Jeremy , Pietsch Fabian , Walterspacher Stephan 
Published: April 2024

AbstractA frequent problem in applied time series analysis is the identification of dominating periodic components. A particularly difficult task is to distinguish deterministic periodic signals from periodic long memory. In this paper, a family of test statistics based on Whittle’s Gaussian log-likelihood approximation is proposed. Asymptotic critical regions and bounds for the asymptotic power are derived. In cases where a deterministic periodic signal and periodic long memory share the same frequency, consistency and rates of type II error probabilities depend on the long-memory parameter. Simulations and an application to respiratory muscle training data illustrate the results.
First-line pembrolizumab plus chemotherapy for advanced/metastatic esophageal cancer: 1-year extended follow-up in the Japanese subgroup of the phase 3 KEYNOTE-590 study
Authors: Kato Ken , Kojima Takashi , Hara Hiroki , Tsuji Akihito , Yasui Hisateru , Muro Kei , Satoh Taroh , Ogata Takashi , Ishihara Ryu , Goto Masahiro , Baba Hideo , Nishina Tomohiro , Han ShiRong , Iwakami Keiichi , Yatsuzuka Naoyoshi , Doi Toshihiko 
Published: April 2024

Abstract
Background
First-line pembrolizumab plus chemotherapy (pembrolizumab–chemotherapy) demonstrated improved efficacy and a manageable safety profile versus placebo plus chemotherapy (placebo–chemotherapy) in the subgroup analysis of Japanese patients with advanced/metastatic esophageal cancer in KEYNOTE-590 at a median follow-up of 24.4 months. Longer-term data from the Japanese subgroup analysis of KEYNOTE-590 are reported.

Methods
Patients were randomly assigned 1:1 to pembrolizumab 200 mg or placebo every 3 weeks for ≤ 35 cycles plus chemotherapy (cisplatin 80 mg/m2 and 5-fluorouracil 800 mg/m2/day). Endpoints included overall survival (OS) and progression-free survival (PFS; investigator-assessed per RECIST v1.1; dual primary) and safety (secondary). Early tumor shrinkage (ETS) and depth of response (DpR) were assessed post hoc.

Results
Overall, 141 patients were enrolled in Japan. As of July 9, 2021, median follow-up was 36.6 months (range, 29.8–45.7). Pembrolizumab–chemotherapy showed a trend toward favorable OS (hazard ratio [HR], 0.70; 95% confidence interval [CI] 0.47–1.03) and PFS (0.57; 0.39–0.83) versus placebo–chemotherapy. In the pembrolizumab–chemotherapy group, patients with ETS ≥ 20% (55/74; 74.3%) versus < 20% (19/74; 25.7%) had favorable OS (HR, 0.23; 95% CI 0.12–0.42) and PFS (0.24; 0.13–0.43). Patients with DpR ≥ 60% (31/74; 41.9%) versus < 60% (43/74; 58.1%) had favorable OS (HR, 0.37; 95% CI 0.20–0.68) and PFS (0.24; 0.13–0.43). Grade 3–5 treatment-related adverse events occurred in 55/74 patients (74.3%) with pembrolizumab–chemotherapy and 41/67 patients (61.2%) with placebo–chemotherapy.

Conclusions
With longer-term follow-up of Japanese patients with advanced/metastatic esophageal cancer, efficacy continued to favor pembrolizumab–chemotherapy compared with placebo–chemotherapy, with no new safety signals observed.
Clinical trial registration: ClinicalTrials.gov, NCT03189719.
Evaluation of novel PCR-based method to assess gill injuries in fish caused by the cnidarian Ectopleura larynx
Authors: Bloecher Nina , Østevik Liv , Floerl Oliver , Sivertsgård Rolf , Aas Marianne , Kvaestad Bjarne , Ribičić Deni , Netzer Roman 
Published: April 2024

AbstractGill disease is a major threat to aquaculture of Atlantic salmon, with an unknown and likely underestimated contribution from cnidarians such as jellyfish and biofouling hydroids. To better understand the risk and thus enable mitigation, technology for the certain identification of cnidarian-related gill damage is needed. We used the hydroid Ectopleura larynx in a case study to determine whether the exposure of salmon to nematocyst-bearing hydrozoans can be deducted via non-destructive PCR-based methods. In a field experiment, we evaluated (i) whether swabbing the inside of the gill operculum in farmed Salmo salar and subsequent PCR analysis can provide quantifiable information about the presence of E. larynx material in the gill chamber and, if so, (ii) whether the screening results correlate with histological assessments of gill damage. The developed PCR methods were able to detect the presence of biofouling hydroids in ambient water. However, despite exposure to suspended hydroid particle concentrations that did result in gill damage in some salmon, quantitative PCR results did not correlate with histological gill assessments. For opercular swabs to serve as a diagnostic tool for detecting biofouling-mediated gill damage in live salmon, increased specificity of genetic markers and improved sampling methods are needed.Animal trial permit no. 24252 (granted 06.07.2020, Norwegian Food Safety Authority).
Different phenological behaviour of native and exotic grasses extends the period of pollen exposure with clinical implications in the Madrid Region, Spain
Authors: Galán Díaz Javier , Romero-Morte Jorge , Cascón Ángel , Gutiérrez-Bustillo Adela Montserrat , Cervigón Patricia , Rojo Jesús 
Published: April 2024

AbstractExotic allergenic species constitute an important element of global change and are an emergent health issue in Europe due to their potential allergenicity. The grass pollen season is of great importance from the allergic point of view because it includes pollen from ubiquitous species which are responsible for high sensitization rates. In this study, we used flowering phenology data for dominant grass species in the city of Madrid (Spain) and airborne pollen data to explore differences between native and exotic species and their potential contribution to the observed peaks of pollen exposure. We found that exotic grasses flowered later than Mediterranean native grasses, and that ornamental grass species (such as Cortaderia selloana and Pennisetum villosum) cause an unusual second pollen season in autumn with implications for public health. These results support the need to coordinate the efforts of plant ecologists and aerobiologists to protect the population by identifying sources of allergenic pollen and sustain the appropriate urban plans.
Microarray-based detection and expression analysis of drug resistance in an animal model of peritoneal metastasis from colon cancer
Authors: Yagublu Vugar , Bayramov Bayram , Reissfelder Christoph , Hajibabazade Javahir , Abdulrahimli Shalala , Keese Michael 
Published: April 2024

AbstractChemotherapy drugs efficiently eradicate rapidly dividing differentiated cells by inducing cell death, but poorly target slowly dividing cells, including cancer stem cells and dormant cancer cells, in the later course of treatment. Prolonged exposure to chemotherapy results in a decrease in the proportion of apoptotic cells in the tumour mass. To investigate and characterize the molecular basis of this phenomenon, microarray-based expression analysis was performed to compare tHcred2-DEVD-EGFP-caspase 3-sensor transfected C-26 tumour cells that were harvested after engraftment into mice treated with or without 5-FU. Peritoneal metastasis was induced by intraperitoneal injection of C-26 cells, which were subsequently reisolated from omental metastatic tumours after the mice were sacrificed by the end of the 10th day after tumour injection. The purity of reisolated tHcred2-DEVD-EGFP-caspase 3-sensor-expressing C-26 cells was confirmed using FLIM, and total RNA was extracted for gene expression profiling. The validation of relative transcript levels was carried out via real-time semiquantitative RT‒PCR assays. Our results demonstrated that chemotherapy induced the differential expression of mediators of cancer cell dormancy and cell survival-related genes and downregulation of both intrinsic and extrinsic apoptotic signalling pathways. Despite the fact that some differentially expressed genes, such as BMP7 and Prss11, have not been thoroughly studied in the context of chemoresistance thus far, they might be potential candidates for future studies on overcoming drug resistance.
Working Retirees? A Liberal Case for Retirement as Free Time
Authors: Valente Manuel Sá 
Published: April 2024

AbstractRetirement is often viewed as a reward for a working life. While many have reason to want a work-free retirement, not everyone does. Should working retirees have to give up their retirement pension and, consequently, their status as retirees? The answer, I argue, boils down to whether we conceive of retirement as free time (need-free) or as leisure (work-free). In this article, I put forward a liberal case in favour of free time, despite whether our liberalism leans towards perfectionism or neutralism, with social primary goods being a case in point. Applying this case for free time to retirement yields two significant policy implications. First, it demands “free synchronic combination” – that retirees may use their retirement pensions however they see fit, including to work. Second, it also yields “free diachronic combination” – that, within limits, individuals have discretionary control over how to combine retirement and work across time – thus challenging the idea that retirement should be available only in old age and not earlier in life. So far, the literature on free time focused only on narrow temporal units, such as hours and days, but there is much to gain by extending the concept into retirement.
How do Children with Intellectual Disabilities Empathize in Comparison to Typically Developing Children?
Authors: Simon Poline , Nader-Grosbois Nathalie 
Published: April 2024

Abstract
Objectives
Two studies were conducted to better understand how children with intellectual disabilities (ID) empathize with the feelings of others during social interactions. The first study tested hypotheses of developmental delay or difference regarding empathy in 79 children with ID by comparing them with typically developing (TD) children, matched for developmental age or chronological age. The second study examined specific aspects of empathy in 23 children with Down syndrome (DS), compared with 23 nonspecific ID children, matched for developmental age, and TD children, matched for developmental age or chronological age.

Method
An empathy task was administered to the children while their parents completed the French versions of the Empathy Questionnaire and the Griffith Empathy Measure.

Results
The first study showed that ID children showed delayed empathy development but were perceived by their parents as deficient in cognitive empathy. The second study showed that DS children were perceived as being more attentive to the feelings of others than TD children and non-specific ID children, matched for developmental age, and as having affective empathy that was similar to that of TD children matched for chronological age.

Conclusion
These studies have drawn attention to delays or differences in different dimensions of empathy in children with ID and DS, which need to be taken into account in interventions.
Age-Differential Effects of Proactive Control in Dual Tasking: The Moderating Effect of Task Difficulty
Authors: Hu Yue , Fung Helene H. , Gong Xianmin 
Published: April 2024

AbstractDual tasking refers to the ability to perform two concurrent tasks. Using the psychological refractory period (PRP) paradigm, two experiments examined whether providing a prompt that facilitated proactive control could benefit dual-task performance among younger and older adults. In Experiment 1, difficulty-related prompt words (“difficult,” “easy,” or null) were presented before easier dual tasks with a longer stimulus onset asynchrony (SOA) of 800 ms or harder tasks with a shorter SOA of 100 ms. Experiment 2 extended the investigation by presenting these prompts (“difficult” or “easy”) before dual tasks with a fixed SOA of 150 ms. It also examined the moderating effects of actual task difficulty by manipulating task congruency. Both experiments suggested that proactive control triggered by difficulty-related prompts facilitated dual-task performance in both age groups. Notably, prompts benefited younger adults’ dual-task performance only when the actual task difficulty was relatively higher, but they benefited older adults’ dual-task performance regardless of the actual task difficulty. These findings contribute to our understanding of proactive control and the different effects of prompts on cognitive performance among younger and older adults.
Broad Perspectives of the Experience of Romantic Relationships and Sexual Education in Neurodivergent Adolescents and Young Adults
Authors: Smusz Magdalena , Allely Clare S. , Bidgood Amy 
Published: April 2024

AbstractNeurodivergent young people tend to struggle with building and maintaining their romantic relationships. Despite this, there appears to be a lack of appropriate sexuality education delivered to them. This review aims to present and discuss the most current literature (conducted between 2015 and current) on romantic relationships and sexuality education in young people with Autism Spectrum Disorder (ASD), Attention-Deficit/Hyperactivity Disorder (ADHD), and ASD co-occurring with ADHD. Six internet-based bibliographic databases were used for the present review that followed the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines. Thirty-one studies were identified in this review. Twenty-six studies investigated the topic in the autistic young population. Four studies explored qualitatively and 11 quantitatively young people’s perspectives of their romantic relationship experiences. One study investigated qualitatively and three quantitatively young people’s perspectives on sexuality education. One study explored qualitatively and five quantitatively young people’s romantic relationship experiences and two explored qualitatively and three quantitatively sexuality education from caregivers’ perspectives. Five studies (all quantitative, self-reports) investigated romantic relationship experiences in the young population with ADHD. The studies conducted on the topic from the educational professionals’ perspectives were absent in the literature. The literature was also non-existent on the topic in the population with ASD co-occurring with ADHD. To the researchers’ knowledge, this is the first review exploring romantic relationships and sexuality education in three groups of neurodivergent young people (with ASD, ADHD, and ASD co-occurring with ADHD).
Punishing Women for Miscarriage: The role of Political Orientation and Hostile Sexism
Authors: Chalmers Jocelyn , Woodford Leif , Sutton Robbie M. 
Published: April 2024

AbstractWomen’s reproductive autonomy is an ideologically divisive issue, and this divisiveness goes beyond just attitudes toward abortion to include other outcomes such as miscarriage. Previous research has established that hostile sexism is positively associated with punitive attitudes toward pregnant women who flout conventional pregnancy proscriptions. Across three studies (N1 = 296; N2 = 580, N3 = 308) we conceptually replicated this research while shifting the focus from abstract attitudes to concrete policies punishing women for miscarriage, and moving beyond hostile sexism to examine the role of political orientation (including libertarianism). In all three studies, hostile sexism remained a significant positive predictor of support for punishing women for miscarriage even after controlling for political orientation. Conservative and libertarian self-identification were positively associated with support for punishment at zero-order, and in multiple regressions adjusting for sexism and demographic variables, conservatism remained significantly positively related to support for punishment in two studies. Libertarianism was no longer a significant predictor of support for punishment after adjusting for sexism; with this in mind, we conducted mediation analyses and found significant indirect paths from libertarian identification through hostile sexism in two of the three studies. These findings provide evidence for the role of sexism and political ideology in the increasingly punitive post-Roe vs. Wade United States.