bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical characteristics and outcomes of alcohol septal ablation in the era of transcatheter valve interventions
Authors: Engel Gonzalez Pedro , Gregerson Samuel , Mahmood Shazil , Brooks Collin , Villablanca Pedro A. , Frisoli Tiberio M. , Lee James , Wyman Janet F. , Wang Dee Dee , O'Neill William W. , O'Neill Brian P. 
Published: April 2024

AbstractBackgroundThe clinical efficacy and safety of alcohol septal ablation (ASA) for obstructive hypertrophic cardiomyopathy (HCM) have been well‐established; however, less is known about outcomes in patients undergoing preemptive ASA before transcatheter mitral valve replacement (TMVR).AimsThe goal of this study is to characterize the procedural characteristics and examine the clinical outcomes of ASA in both HCM and pre‐TMVR.MethodsThis retrospective study compared procedural characteristics and outcomes in patient who underwent ASA for HCM and TMVR.ResultsIn total, 137 patients were included, 86 in the HCM group and 51 in the TMVR group. The intraventricular septal thickness (mean 1.8 vs. 1.2 cm; p < 0.0001) and the pre‐ASA LVOT gradient (73.6 vs. 33.8 mmHg; p ≤ 0.001) were higher in the HCM group vs the TMVR group. The mean volume of ethanol injected was higher (mean 2.4 vs. 1.7 cc; p < 0.0001). The average neo‐left ventricular outflow tract area increased significantly after ASA in the patients undergoing TMVR (99.2 ± 83.37 mm2 vs. 196.5 ± 114.55 mm2; p = <0.0001). The HCM group had a greater reduction in the LVOT gradient after ASA vs the TMVR group (49.3 vs. 18 mmHg; p = 0.0040). The primary composite endpoint was higher in the TMVR group versus the HCM group (50.9% vs. 25.6%; p = 0.0404) and had a higher incidence of new permanent pacemaker (PPM) (25.5% vs. 18.6%; p = 0.3402). The TMVR group had a higher rate of all‐cause mortality (9.8% vs. 1.2%; p = 0.0268).ConclusionsPreemptive ASA before TMVR was performed in patients with higher degree of clinical comorbidities, and correspondingly is associated with worse short‐term clinical outcomes in comparison to ASA for HCM patients. ASA before TMVR enabled percutaneous mitral interventions in a small but significant minority of patients that would have otherwise been excluded. The degree of LVOT and neoLVOT area increase is significant and predictable.
Device regulation and surveillance in vascular care: Challenges and opportunities
Authors: Pyun Alyssa J. , Goodney Philip P. , Eldrup‐Jorgensen Jens , Wadzinski James , Secemsky Eric A. , Cigarroa Joaquin E. 
Published: April 2024

AbstractCardiovascular devices are essential for the treatment of cardiovascular diseases including cerebrovascular, coronary, valvular, congenital, peripheral vascular and arrhythmic diseases. The regulation and surveillance of vascular devices in real‐world practice, however, presents challenges during each individual product's life cycle. Four examples illustrate recent challenges and questions regarding safety, appropriate use and efficacy arising from FDA approved devices used in real‐world practice. We outline potential pathways wherein providers, regulators and payors could potentially provide high‐quality cardiovascular care, identify safety signals, ensure equitable device access, and study potential issues with devices in real‐world practice.
Successful treatment of severe primary mitral regurgitation due to rheumatic aetiology using a novel‐designed transcatheter edge‐to‐edge repair system
Authors: Xie Chun‐Mei , Zhu Da , Wang Shou‐Zheng , Pan Xiang‐Bin 
Published: April 2024

AbstractThe transcatheter edge‐to‐edge mitral valve repair (TEER) has been recommended as a reliable treatment option for selected patients with severe degenerative and functional mitral regurgitation (MR). Although MR patients with rheumatic etiology were excluded from two significant trials (EVEREST II and COAPT) that established a role for the TEER in degenerative and functional MR. However, it has been reported that the TEER procedure could be safely and effectively performed in carefully selected rheumatic MR patients. Therefore, we share a case report of successfully treating severe rheumatic MR using a novel‐designed TEER system (JensClipTM).
A short note on deep contextual spatial and spectral information fusion for hyperspectral image processing: Case of pork belly properties prediction
Authors: Mishra Puneet , Albano‐Gaglio Michela , Font‐i‐Furnols Maria 
Published: April 2024

AbstractThis study demonstrates a new approach to process hyperspectral images where both the contextual spatial information as well as the spectral information are used to predict sample properties. The deep contextual spatial information is extracted using the deep feature extraction from pretrained resnet‐18 deep learning architecture, while the spectral information was readily available as the average pixel values. To fuse the information in a complementary way, a multiblock modeling approach called sequential orthogonalized partial least squares was used. The sequential model guarantees that the information learned is complementary from spatial and spectral domains. The potential of the approach is demonstrated to predict several physical and chemical properties in pork bellies.
Hollow UiO‐66‐NH2 Encapsulated Pd Catalysts for Highly Selective Hydrogenation of Furfural to Furfuryl Alcohol
Authors: Zhao Bo , Yao Yao , Huang Kexin , Li Jiaxin , Chen Minjie , Liu Chao , Xu Hongjian , Zhao Xinyu , Chang Ganggang 
Published: April 2024

AbstractThe selective hydrogenation of furfural (FFA) to furfuryl alcohol (FA) is regarded as attractive transformation to achieve the sustainable synthesis of value‐added chemicals from biomass resources. However, the conventional supported catalysts are significantly restricted by their narrow pore size, ununiform dispersion and easy leaching or aggregation of catalytic sites. Herein, we designed hollow UiO‐66‐NH2 as the support to encapsulate Pd nanoparticles (Pd@H‐UiO‐66‐NH2) to achieve the highly active and selective conversion of FFA to FA. Benefiting from the void‐confinement effect and substrate enrichment of hollow structure, as well as the surface wrinkles, the as‐prepared catalyst Pd@H‐UiO‐66‐NH2 exhibited 96.8 % conversion of FFA with satisfactory selectivity reaching up to 92.4 % at 80 °C, 0.5 MPa H2 in isopropanol solvent within 6 h. More importantly, as‐prepared Pd@H‐UiO‐66‐NH2 catalyst exhibited excellent long‐term stability, as well as good universality toward a series of hydrogenation of unsaturated hydrocarbons.
The recycling of sulphur in waste and conversion to manganese sulphate: Process optimization, kinetic study, mechanistic insights
Authors: Yan Hao , Tong Wenhua , Wang Jiepeng , Li Panyu , Wang Xuqian , Zhang Yongkui 
Published: April 2024

AbstractWaste sulphur produced in industrial processes is often exposed to the air, and its diffusion and combustion in the environment can produce harmful substances, posing a significant risk to ecological safety and human health. Herein, a novel method for the direct treatment of solid sulphur with manganese dioxide based on a simple sealed reactor is proposed. Significantly, the developed sulphur treatment technology could prepare high purity manganese sulphate at the same time. Under the optimum conditions of the reaction temperature of 187.2°C, reaction time of 21.6 h, sulphuric acid loading of 1.00 mol ∙ L−1, and manganese dioxide dosage of 4.00 mol ∙ mol‐S−1 derived by the response surface method (RSM), the removal efficiency of sulphur could reach near 100%, and the purity of the manganese sulphate product obtained was more than 98%. Kinetic model fitting analysis and several characterization methods were adopted to confirm that the reaction process between sulphur and manganese dioxide follows the unreacted nuclear model controlled by surface chemical reaction, and the transformation paths of Mn and S elements were proposed. This study provides a novel method for the resource treatment of waste sulphur and the preparation of high purity manganese sulphate.
Developing Low Molecular Weight PET and SPECT Imaging Agents
Authors: Xue Lian , Jie Caitlin V. M. L. , Desrayaud Sandrine , Auberson Yves P. 
Published: April 2024

AbstractImaging agents for positron emission tomography (PET) and single‐photon emission computerized tomography (SPECT) have shown their utility in many situations, answering clinical questions related to drug development and medical considerations. The discovery and development of imaging agents follow a well‐understood process, with variations related to available starting points and to the envisaged imaging application. This article describes the general development path leading from the expression of an imaging need and project initiation to a clinically usable imaging agent. The definition of the project rationale, the design and optimization of early leads, and the assessment of the imaging potential of an imaging agent candidate are followed by preclinical and clinical development activities that differ from those required for therapeutic agents. These include radiolabeling with a positron emitter and first‐in‐human clinical studies, to rapidly evaluate the ability of a new imaging agent to address the questions it was designed to answer.
Synthesis of Silver Nanostructures on Different Supports: From Nanoparticle Decoration to a Complete Shell Growth
Authors: Macchione Micaela A. , Moiraghi Raquel , Passarelli Nicolas , Coronado Eduardo A. , Pérez Manuel A. 
Published: April 2024

AbstractIn this work, we investigate a complete strategy to obtain supported silver nanostructures (AgNSs) which can be used for different applications such as catalysis, optoelectronics, and biomedical devices. Given the poor wetting of silver on many support materials, the anchorage of silver nanoparticles (AgNPs) to the substrate (decoration) is achieved by employing an oxide precipitation‐decomposition method. This protocol is optimized to obtain rapid and homogeneous decoration of AgNPs on different substrates such as silica, titania, and hydroxyapatite with a negligible production of free‐standing silver nanoparticles. Going a step further, we have also studied the growth of AgNPs attached to silica spheres (SiO2NPs) using a seed‐mediated growth strategy. The interplay of different processes like growth, corrosion, coalescence, and sintering determines the morphological features of the grown nanoparticles. Therefore, the substrate coverage and nanoparticle morphology can be qualitatively modified by varying the composition of the growth bath. The observed growth is consistent with a radial growth mechanism which, in most experimental conditions, allows for the production of anisotropic AgNSs onto silica surface. In addition, if the corrosion effects are minimized, the coalescence process of neighboring particles can lead to high surface coverages.
What are the drivers of female success in food‐deceptive orchids?
Authors: Wróblewska Ada , Ostrowiecka Beata , Kotowicz Jarosław , Jermakowicz Edyta , Tałałaj Izabela , Szefer Piotr 
Published: April 2024

AbstractA large suite of floral signals, and environmental and biotic characteristics influence the behavior of pollinators, affecting the female success of food‐deceptive orchids. In this study, we examined the many factors shaping the reproductive output of three orchid taxa: Dactylorhiza majalis, D. incarnata var. incarnata, and D. fuchsii. We applied a statistical model to correlate female success (number of fruit sets) with individual characteristics (plant and inflorescence height, number of flowers, and spur length), number of pollinaria removed, flowering time, and density of floral units of co‐flowering rewarding plants. Our findings suggested that the broad spectrum of variations in Dactylorhiza's morphological traits, floral display, and flowering phenology within different environmental contexts has a significant impact on their reproductive success. The number of fruits increased with an increase in the number of pollinaria removed in the studied Dactylorhiza taxa. In contrast, a higher number of flowers per inflorescence and higher inflorescences in relation to individual height always decreased fruit set. We observed that low number of co‐flowering rewarding plants in populations could affect the Dactylorhiza reproductive output as magnets and competitor plants. The synchronization of flowering, or lack thereof, between Dactylorhiza and rewarding plants can limit reproductive success. This demonstrates that the food deception strategy is multidirectional, and reproductive output can vary considerably both spatially and temporally within the context of this strategy.
Representativeness of the PIONEER‐HF and PARAGLIDE‐HF in patients hospitalized with acute heart failure
Authors: Chen Dong‐Yi , Chen Chun‐Chi , Lee Cheng‐Hung , Tseng Chi‐Nan , Chen Shao‐Wei , Chang Shang‐Hung , Chen Tien‐Hsing , Chu Pao‐Hsien , Hsieh I‐Chang , Wen Ming‐Shien , Tsai Ming‐Lung , Hsieh Ming‐Jer 
Published: April 2024

AbstractAimsThe PIONEER‐HF and PARAGLIDE‐HF trials aimed to determine the efficacy and safety of the in‐hospital initiation of sacubitril/valsartan in patients hospitalized for AHF. However, whether the inclusion and exclusion criteria of the trials apply to patients encountered in real‐world routine care is unclear. This study aimed to investigate the applicability of the PIONEER‐HF and PARAGLIDE‐HF trials to real‐world AHF patients.Methods and resultsWe identified 28 293 AHF hospitalized patients between August 2008 to August 2017 from the Chang Gung Research Database and classified them into four groups based on left ventricular ejection fraction (LVEF) and trial criteria. Cox proportional hazards models were used to compare the risk of HF hospitalization and cardiovascular (CV) death. We defined PIONEER‐HF eligible (n = 3683) and non‐eligible (n = 3502) patients with an LVEF ≤40%, and PARAGLIDE‐HF eligible (n = 5191) and non‐eligible (n = 5832) patients with an LVEF >40%. Over a mean follow‐up of 3.5 years, the PIONEER‐HF non‐eligible and eligible groups exhibited similar rates of HF hospitalization and CV death (41.1% vs. 41.8%, adjusted hazard ratio [aHR]: 0.95; 95% CI: 0.88–1.04). No significant difference was found in the composite outcome between PARAGLIDE‐HF non‐eligible and eligible groups (36.7% vs. 38.6%; aHR: 0.97; 95% CI: 0.90–1.04).ConclusionsUsing trial criteria, only 31.3% of AHF patients were eligible for sacubitril–valsartan. Yet, non‐eligible patients demonstrated similar outcomes to eligible patients, indicating a need for further evaluation of sacubitril–valsartan benefits in non‐eligible AHF patients.
Circulating miRNA in functional tricuspid regurgitation. Unveiling novel links to heart failure: A pilot study
Authors: Hinojar Rocio , Moreno‐Gómez‐Toledano Rafael , Conde Elisa , Gonzalez‐Gomez Ariana , García‐Martin Ana , González‐Portilla Paz , Fernández‐Golfín Covadonga , García‐Bermejo Maria Laura , Zaragoza Carlos , Zamorano Jose Luis 
Published: April 2024

AbstractAimSevere functional tricuspid regurgitation (FTR) is associated with high risk of cardiovascular events, particularly heart failure (HF) and mortality. MicroRNAs (miRNAs) have been recently identified as novel biomarkers in different cardiovascular conditions, but no studies have focused on FTR. We sought to (1) to identify and validate circulating miRNAs as regulators of FTR and (2) to test association of miRNA with heart failure and mortality in FTR.Methods and resultsConsecutive patients with isolated severe FTR (n = 100) evaluated in the outpatient Heart Valve Clinic and age‐ and gender‐matched subjects with no TR (controls, n = 50) were prospectively recruited. The experimental design included (1) a screening phase to identify candidate miRNA differentially expressed in FTR (n = 8) compared with controls (n = 8) through miRNA array profiling of 192 miRNAs using quantitative reverse transcription PCR arrays [qRT‐PCR]) and (2) a validation phase in which candidate miRNAs identified in the initial screening were selected for further validation by qRT‐PCR in a prospectively recruited cohort of FTR (n = 92) and controls (n = 42). Bioinformatics analysis was used to predict their potential target genes and functional pathways elicited. A combined endpoint of hospital admission due to heart failure (HF) and all‐cause mortality was defined. Initial screening identified 16 differentially expressed miRNAs in FTR compared with controls, subsequently confirmed in the validation phase (n = 16 were excluded due to significant haemolysis). miR‐186‐5p, miR‐30e‐5p, and miR‐152‐3p identified FTR with high predictive value [AUC of 0.93 (0.88–0.97), 0.83 (0.75–0.91) and 0.84 (0.76–0.92), respectively]. During a median follow‐up of 20.4 months (IQR 8–35 months), 32% of FTR patients reached the combined endpoint. Patients with low relative expression of miR‐15a‐5p, miR‐92a‐3p, miR101‐3p, and miR‐363‐3p, miR‐324‐3p, and miR‐22‐3p showed significantly higher rates of events (log‐rank test for all P < 0.01). Both miR‐15a‐5p [hazard ratio: 0.21 (0.06–0.649, P = 0.007) and miR‐92a‐3p (0.27 (0.09–0.76), P = 0.01] were associated with outcomes after adjusting for age, gender, and New York Heart Association functional class.ConclusionsCirculating miRNAs are novel diagnostic and prognostic biomarkers in severe FTR. The quantification of miR‐186‐5p, miR‐30e‐5p, and miR‐152‐3p held strong diagnostic value, and the quantification of miR‐15a‐5p and miR‐92a‐3p are independently associated with outcomes. The recognition of specific miRNAs offers a novel perspective for TR evaluation.
Exercise limitation in hypertrophic cardiomyopathy: combined stress echocardiography and cardiopulmonary exercise test
Authors: Erez Yonatan , Ghantous Eihab , Shetrit Aviel , Zamanzadeh Ryan S. , Zahler David , Granot Yoav , Sapir Orly Ran , Laufer Perl Michal , Banai Shmuel , Topilsky Yan , Havakuk Ofer 
Published: April 2024

AbstractAimsThe study aims to investigate exercise‐limiting factors in hypertrophic cardiomyopathy (HCM) using combined stress echocardiography and cardiopulmonary exercise test.Methods and resultsA symptom‐limited ramp bicycle exercise test was performed in the semi‐supine position on a tilting dedicated ergometer. Echocardiographic images were obtained concurrently with gas exchange measurements along predefined stages of exercise. Oxygen extraction was calculated using the Fick equation at each activity level. Thirty‐six HCM patients (mean age 67 ± 6 years, 72% men, 18 obstructive HCM) were compared with age and sex‐matched 29 controls. At rest, compared with controls, E/E′ ratio (6.26 ± 2.3 vs. 14 ± 2.5, P < 0.001) and systolic pulmonary artery pressures (SPAP) (22.6 ± 3.4 vs. 34 ± 6.2 mmHg, P = 0.023) were increased. Along with the stages of exercise (unloaded; anaerobic threshold; peak), diastolic function worsened (E/e′ 8.9 ± 2.6 vs. 13.8 ± 3.6 P = 0.011; 9.4 ± 2.3 vs. 18.6 ± 3.3 P = 0.001; 8.7 ± 1.9 vs. 21.5 ± 4, P < 0.001), SPAP increased (23 ± 2.7 vs. 33 ± 4.4, P = 0.013; 26 ± 3.2 vs. 40 ± 2.9, P < 0.001; 26 ± 3.5 vs. 45 ± 7 mmHg, P < 0.001), and oxygen consumption (6.6 ± 1.7 vs. 6.8 ± 1.6, P = 0.86; 18.1 ± 2.2 vs. 14.6 ± 1.5, P = 0.008; 20.3 ± 3 vs. 15.1 ± 2.1 mL/kg/min, P = 0.01) was reduced. Oxygen pulse was blunted (6.3 ± 1.8 vs. 6.2 ± 1.9, P = 0.79; 10 ± 2.1 vs. 8.8 ± 1.6, P = 0.063; 12.2 ± 2 vs. 8.2 ± 2.3 mL/beat, P = 0.002) due to an insufficient increase in both stroke volume (92.3 ± 17 vs. 77.3 ± 14.5 P = 0.021; 101 ± 19.1 vs. 87.3 ± 15.7 P = 0.06; 96.5 ± 12.2 vs. 83.6 ± 16.1 mL, P = 0.034) and oxygen extraction (0.07 ± 0.03 vs. 0.07 ± 0.02, P = 0.47; 0.13 ± 0.02 vs. 0.10 ± 0.03, P = 0.013; 0.13 ± 0.03 vs. 0.11 ± 0.03, P = 0.03). Diastolic dysfunction, elevated SPAP, and the presence of atrial fibrillation were associated with reduced exercise capacity.ConclusionsBoth central and peripheral cardiovascular limitations are involved in exercise intolerance in HCM. Diastolic dysfunction seems to be the main driver for this limitation.
Magnetic Single‐Ion Anisotropy and Curie‐Weiss Behaviour of Mg3V4(PO4)6
Authors: Schwarz Björn , Fu Qiang 
Published: April 2024

AbstractDirect current (DC) magnetometry data obtained for polycrystalline Mg3V4(PO4)6 were fitted by various magnetic models based on angular momentum basis states. As a result, single‐ion anisotropy of the magnetic V 3+ ions could be identified to decisively determine the magnetic properties of Mg3V4(PO4)6 and not antiferromagnetic exchange interaction between V ions as supposed in literature. It could be demonstrated analytically, by utilization of the Van Vleck equation, that also single‐ion anisotropy can lead to a linear and origin shifted inverse susceptibility curve in the high temperature region. The Weiss constant obtained from a Curie‐Weiss fit to such a susceptibility curve might falsely be ascribed to antiferromagnetic exchange interactions if additional low temperature magnetic properties are not considered for verification.
An experimental comparison of thermal energy storage in directly and indirectly radiated adsorbent beds integrated with solar thermal collectors
Authors: Narwal Kapil , Massah Fatemeh , Kempers Roger , O'Brien Paul G. 
Published: April 2024

AbstractAdsorbents heated using solar energy can be used to achieve thermal energy storage and sorption refrigeration with low environmental impacts. This research compares two different methods of heating adsorbents with solar energy to store thermal energy: (1) by exposing the adsorbents to incident light transmitted through a solar collector window, and (2) by heating a highly absorbing solar collector cover, and then transferring the heat from this solar absorber to adsorbents located beneath it. To carry out this comparison experiments are conducted for three cases of adsorbent beds using zeolite 13X and water as the adsorbent‐adsorbate pair. In the first case, the top of the adsorbent bed is a polycarbonate sheet, and the zeolites are heated directly by solar‐simulated light transmitted through this sheet. In the second case, a blackened aluminum sheet is placed beneath the polycarbonate sheet to generate heat by absorbing incident light. For the third case, the blackened aluminum absorber is placed directly on top of the zeolite beads and the absorber is isolated from the walls of the reactor to avoid heat losses. The outcomes reveal an energy storage density (ESD) of 43.6 kWh/m3 (63.4 Wh/kg) when light is directly incident onto the zeolite 13X and an ESD of 33.3 kWh/m3 (48.4 Wh/kg) when light is incident onto a blackened absorber plate that transfers heat to Zeolite beads residing beneath it. However, ESD values were improved to 48.9 kWh/m3 (71.0 Wh/kg) when the blackened absorber plate was thermally insulated from the walls of the adsorbent bed. These results demonstrate the importance of an optimal absorber arrangement in enhancing the adsorption process for the purpose of elevating energy storage densities.