bluuebunny/crossref_metadata_2025_split huggingface dataset:
Theoretical Boundaries of Annual Flood Risk for Single-Family Homes Within the 100-Year Floodplain
Authors: Al Assi Ayat , Mostafiz Rubayet Bin , Friedland Carol J. , Rohli Robert V. 
Published: March 2024

AbstractSpecial flood hazard areas (SFHAs), defined as having an annual probability of occurrence of 1 percent or above, are used by U.S. Federal Emergency Management Agency (FEMA) to demarcate areas within which flood insurance purchase is required to secure a mortgage. However, quantifying flood risk within SFHAs can be challenging due to the lack of modeled flood depth data for all return periods. To address this issue, this research quantifies flood risk indicated by average annual loss (AAL) within the A Zone—the subset of the SFHA where wave heights can potentially range from 0 to 3 feet. The methodology resolves the Gumbel quantile function for four distinct flooding cases (i.e., locations flooded at return periods exceeding 1.58-, 10-, 25-, and 50-year return period events) and generates synthetic flood hazard parameters for these cases within the 100-year floodplain, as well as with additional elevation above the base flood elevation (BFE), known as freeboard, for single-family homes with different attributes. The results indicate that for single-family homes in the A Zone, with the lowest floor elevated to the BFE, the AAL ranges from 0.3 to 1 percent of the building replacement cost value. Adding one foot of freeboard reduces flood risk by over 90% if the annual flood risk is between the minimum and 25th percentiles and the 100-year flood depth is less than two feet. The demonstrated approach helps enhance flood resilience in the A Zone, demonstrating the feasibility of proactive measures to protect communities.
Enhancing flame and electrical surface discharge resistance in silicone rubber composite insulation through aluminium hydroxide, clay, and glass fibre additives
Authors: Nazir M. Tariq , Khalid Arslan , Wang Cheng , Kabir Imrana , Yeoh Guan H. , Phung B. Toan 
Published: March 2024

AbstractSilicone rubber (SR) is a leading polymer used in electrical outdoor insulation applications due to its superior hydrophobic characteristics. However, the low flame and electrical surface discharge resistance of SR limit its broad viability and challenge its integrity in severe outdoor working conditions. This work attempts to explore the flame retardancy and surface discharge characteristics of SR co-filled with aluminium hydroxide (ATH), nanoclay montmorillonite (MMT), and chopped glass fibre (GF). Results indicate that the incorporation of ATH/MMT/GF could assist in improving the fire and surface discharge resistance of the SR material. It is noted that the maximum average rate of heat emission (MARHE) and total smoke production (TSP) are measured at 24.93 kW/m2 and 0.48 m2 in SRE, relative to 61.29 kW/m2 and 6.02 m2 in SRB. Using finite element analysis (FEA), the maximum electric field strength is computed at 4.66 × 106 V/m in the air gap coupled with a high-voltage (HV) plate and sample. SRE exhibits a higher partial discharge inception voltage (PDIV) value of 2.32 kVrms than its counterparts, while the maximum discharge magnitude (Qmax) is computed at 7095 pC, relative to 7746 pC in SRB. SRE emerges as a preferable SR composite to be used in electrical insulation applications with excellent flame and surface discharge resistance characteristics.
Secondary metabolite gene clusters from the phytopathogenic fungus Gaeumannomyces tritici
Authors: Geremia Felipe , Paim Igor , da Silva Camargo Matheus , Schrank Augusto , Sbaraini Nicolau 
Published: March 2024

AbstractThe take-all disease is one of the most important maladies in cereals and grasses, being caused by the fungus Gaeumannomyces tritici. Secondary metabolites are known to perform critical functions during the infection process of various phytopathogens. However, the current understanding of the biosynthesis of secondary metabolites in G. tritici is limited. Similarly, comprehensive analyses of the expression, conservation, and evolution of these biosynthesis-related genes are crucial for enhancing our knowledge of the molecular mechanisms that drive the development of the take-all disease. Here we have performed a deep survey and description of secondary metabolite biosynthetic gene clusters in G. tritici, analyzed a previously published RNA-seq of a mimicked infection condition, and assessed the conservation among 10 different Magnaporthales order members. Notably, the majority of the 35 putative gene clusters identified were conserved among these species, with GtPKS1, GtPKS3, and GtTERP4 uniquely identified in G. tritici. In the mimicked infection condition, seven gene clusters, including the GtPKS1 cluster, exhibited upregulated expression. Through comparative genomic analysis, GtPKS1 was associated with the production of dichlorodiaporthin, a metabolite with cytotoxic and antifungal activity. In addition, GtPKS10 and GtPKSNRPS3 showed similarities to already characterized biosynthetic pathways involved in the synthesis of ACR-toxin (phytotoxic) and trichosetin (phytotoxic and antibiotic), respectively. These three gene clusters were further scrutinized through phylogenetic inference, which revealed the distribution of orthologous sequences across various plant-associated fungi. Finally, the detailed identification of several genes enrolled in secondary metabolite biosynthesis provides the foundation for future in-depth research, supporting the potential impact of several small molecules on G. tritici lifecycle and host interactions.
Assessing the impact of missing data on water quality index estimation: a machine learning approach
Authors: Sierra-Porta David 
Published: March 2024

AbstractDespite the regulations and controls implemented worldwide by governments and institutions to ensure the availability and quality of water resources, many water sources remain susceptible to contamination. This contamination poses significant risks to human health and can lead to substantial economic losses. One of the challenges in this context is the presence of missing or incomplete data, which can arise from various factors such as the methodology used or the expertise of personnel involved in sample collection and analysis. The existence of such data gaps hampers the accurate analysis that can be conducted. To address this issue and estimate a water quality index from the available samples, it is crucial to handle missing information appropriately to avoid biased calculations. This study focuses on the application of machine learning methods for imputing missing data in water samples. Furthermore, it quantifies the performance of different models based on the distribution of the obtained data. By applying 10 distinct methods to a sample of water quality data, the most effective approaches, namely Bayesian Ridge, Gradient Boosting, Ridge, Support Vector Machine, and Theil-Sen regressors, were identified. The selection of these models was based on the evaluation of two estimation error metrics: average percent bias (PBIAS) and Kling-Gupta Efficiency statistic (KGEss). The respective metric values for the aforementioned methods are as follows: $$\langle \hbox {PBIAS}\rangle _{0.5}=14.665, 19.555, 14.300, 15.380, 15.920$$

⟨
PBIAS
⟩

0.5

=
14.665
,
19.555
,
14.300
,
15.380
,
15.920

and $$\langle \hbox {KGEss}\rangle _{0.5}=0.670, 0.585, 0.655, 0.620, 0.595$$

⟨
KGEss
⟩

0.5

=
0.670
,
0.585
,
0.655
,
0.620
,
0.595

. The results obtained from these models have been utilized to establish unbiased relationships among physical, chemical, and biological parameters based on the information retrieved through the applied imputation methods.
A residential property appreciation and bank financing feasibility for acquisition in Hermosillo, Sonora
Authors: Ramirez-Uribe Gerardo , Imam Ayman , de la Cruz Arturo Ojeda , Corella Marco Ramos , Pacheco Jesus Quintana 
Published: March 2024

AbstractThis study focuses on the Capital Gain of residential housing and its feasibility through bank financing in Hermosillo, Sonora. The purpose is to analyze the evolution of capital gain in the residential market and assess its possibility of acquisition through bank financing in the region. The main methodology includes a historical analysis of housing prices and a comprehensive evaluation of the current financing conditions provided by local banks. Key findings highlight a sustained increase in the capital gain of residential properties in Hermosillo. Economic and developmental factors have contributed to this constant growth. Furthermore, it has been proven that bank financing is a viable alternative for those interested in acquiring homes in this area. The capital gain in Hermosillo presents a promising outlook for both investors and buyers alike. The upward trend in housing prices, supported by favorable conditions in the local economy and urban development, highlights the potential for investment in the region. The availability of bank financing further facilitates access to the acquisition of residential properties, making it appealing for those seeking to invest in real estate in Hermosillo. In conclusion, this study underscores the viability of acquiring residential properties through bank financing and emphasizes the importance of considering capital gain as a valuable indicator in real estate decision-making in Hermosillo, Sonora.
Asymptotic expansions relating to the distribution of the length of longest increasing subsequences
Authors: Bornemann Folkmar 
Published: March 2024

AbstractWe study the distribution of the length of longest increasing subsequences in random permutations ofnintegers asngrows large and establish an asymptotic expansion in powers of$n^{-1/3}$. Whilst the limit law was already shown by Baik, Deift and Johansson to be the GUE Tracy–Widom distributionF, we find explicit analytic expressions of the first few finite-size correction terms as linear combinations of higher order derivatives ofFwith rational polynomial coefficients. Our proof replaces Johansson’s de-Poissonization, which is based on monotonicity as a Tauberian condition, by analytic de-Poissonization of Jacquet and Szpankowski, which is based on growth conditions in the complex plane; it is subject to a tameness hypothesis concerning complex zeros of the analytically continued Poissonized length distribution. In a preparatory step an expansion of the hard-to-soft edge transition law of LUE is studied, which is lifted to an expansion of the Poissonized length distribution for large intensities. Finally, expansions of Stirling-type approximations and of the expected value and variance of the length distribution are given.
Changing sustainable diet behaviours during the COVID-19 Pandemic: inequitable outcomes across a sociodemographically diverse sample of adults
Authors: Ludwig-Borycz Elizabeth , Baylin Ana , Jones Andrew D. , Webster Allison , Stratton Anne Elise , Bauer Katherine W. 
Published: March 2024

Abstract
The objective of this study was to describe changes in sustainable dietary behaviours (those that support environmental, economic, and physical health) among a sample of US adults during the COVID-19 pandemic and to examine differences in changes by individuals’ race/ethnicity and socioeconomic status. Therefore, a cross-sectional online survey study was conducted in April 2021 (N = 1,488, mean age = 42.7 (SD = 12.6)) receiving outpatient care from Michigan Medicine, the University of Michigan health system. Enrolment quotas were established to ensure a diverse sample—one-third of participants identified as African American/Black, one-third Hispanic/Latino, one-third White, and one-third low-income. Participants reported engaging in more behaviours that are supportive of a sustainable diet one year into the COVID-19 pandemic compared to before. This is particularly true regarding ecologically and economically sustaining behaviours such as taking fewer trips to the grocery store, increased use of home grocery delivery, increased cooking at home, and greater consumption of healthy foods. Not all behaviour changes promoted sustainable food systems; namely, the use of farmer’s markets and Community Supported Agriculture (CSAs) declined. White and high-income participants were more likely than African American/Black, Hispanic/Latino, and low-income individuals to engage in ecologically and economically sustainable dietary behaviours during the pandemic. Meanwhile, African American/Black participants reported large increases in physical health sustainable dietary behaviours. To support the continuation of greater engagement with sustainable diets, policies that increase access to public transportation, limit the frequency with which consumers have groceries delivered, increase work-from-home options, and improve access for low-income populations should be prioritised.
Instant memories of the Russian war against Ukraine – mapping the virtual Meta History: Museum of War
Authors: Graf Sebastian 
Published: March 2024

Abstract
This paper explores how Ukrainian virtual museums of war are embedded in today's connective environment of humans, codes and algorithms. In particular, I examine the ways virtuality as a mode of memory-making is deployed by the Meta History: Museum of War to shape the mediation and remembering of the full-scale Russian war against Ukraine as it unfolds. Using digital methods and digital ethnography, this study maps the emerging assemblage of the Meta History: Museum of War to grasp how the museum is contributing to efforts to repel the Russian invasion through its artistic and material engagement with the war. By exploring the network of exhibitions and the museum's virtual infrastructure, the study illustrates how the museum generates affective instant memories in order to wield influence over events that will in turn be exhibited in the future. Consequently, it adds valuable insights into the production of virtual engagement with war.
Ethics Within the Divine Order – Why Oliveira’s Symmetry Challenge Fails
Authors: Luke Sean 
Published: March 2024

AbstractRecently, Luis R. G. Oliveira has developed the ‘symmetry challenge’ as follows:
(1)If God exists, then for all actual instances of evil e, God has justifying moral reasons for allowing e (the ‘reasons’ thesis).(2)If God has justifying moral reasons for allowing e, then we have justifying moral reasons for allowing e as well (symmetry thesis).(3)So, if God exists, then for all actual instances of e, we have justifying moral reasons for allowing e (Oliveira, 2023).Thus, per Oliveira, given God’s sovereignty over evil, there is no ethical asymmetry which would compel a moral agent to prevent rather than permit a preventable evil. In this paper, I will defend the asymmetry claim and argue that Oliveira’s argument ultimately fails. First, I will sketch Oliveira’s argument. Then, I will briefly articulate a broadly Reformed-Thomistic model of providence which I will deploy in this article. Third, I will argue that this model of providence and the ethical aim of the Christian life generate two distinct yet inter-related reasons to hold to the asymmetry claim. Finally, I will canvas several theodicies my model rules out and anticipate several objections.
Transnational Activism through the Prism of Anarchism, and Vice Versa
Authors: Bantman Constance 
Published: March 2024

AbstractChapter Four of Daniel Laqua's Activism across Borders, on “Class, Revolution and Social Justice”, opens stimulating avenues for reflection with its cross-partisan approach, over an ambitious chronological span – from the post-1848 wave of revolutionary exile to the contemporary global justice movement. From the perspective of a historian of pre-1914 transnational anarchism, this brief review essay considers three prominent aspects of this chapter: historiographic perspectives on socialist activisms; the modalities of transnational activism; and borders and boundaries.
Dark Futures: Toward a Philosophical Archaeology of Hope
Authors: Taylor Paul C. 
Published: March 2024

AbstractEarly in World War I, Virginia Woolf wrote these words: ‘The future is dark, which is on the whole, the best thing the future can be […]’. It is tempting to assume that darkness simply hides the unknown and the threatening. It is more challenging to think of it as Woolf did: rich with possibility in even the most desperate times.We live in what many would readily describe as dark times. These times have brought (among much else) a once-in-a-century public health crisis, the continued redemption of toxic white supremacy, declining trust in and support for public institutions, and growing evidence of impending climate devastation. ‘Dark Futures’ will consider some of the scenes of this devastation and mine them for insights into our predicaments and our prospects.
Assessment of trophic segregation amongst gentoo penguin (Pygoscelis papua) individuals in Antarctica using a non-invasive methodology
Authors: Rabinovich-Larrechea Lucía , Naya Daniel E. , Cosse Mariana , Bou Nadia , Franco-Trecu Valentina 
Published: March 2024

AbstractIndividual trophic specialization (ITS) refers to the trophic diversification amongst individuals within a population. The gentoo penguin (Pygoscelis papua) is considered a trophic generalist at the population level, but little is known about its individual trophic differentiation. We assessed the degree of ITS at one of its main breeding colonies: Ardley Island, South Shetland Islands. We used skin from 19 dead individuals to determine species and sex by molecular methods and a nail for stable isotope analysis of δ15N and δ13C. Isotopic niche metrics and ITS were estimated for the population and for each sex. We found a moderately high degree of ITS associated with the trophic position of the resources consumed (δ15N) for the population and both sexes, as well as a moderate degree of ITS in the foraging habitat (δ13C) for the population and females. Females showed a higher exclusive niche area, suggesting that they use resources and foraging areas that males do not, probably related to reproductive energy demands. Given the high population density of this species, ITS could function as a mechanism to decrease intraspecific competition. This combination of genetic and isotopic tools allowed us to provide relevant information on the trophic ecology of the gentoo penguin without manipulating animals or using invasive methods.
Sex differences in adipose insulin resistance are linked to obesity, lipolysis and insulin receptor substrate 1
Authors: Arner Peter , Viguerie Nathalie , Massier Lucas , Rydén Mikael , Astrup Arne , Blaak Ellen , Langin Dominique , Andersson Daniel Peter 
Published: March 2024

Abstract
Background/Objective
Insulin resistance is more prominent in men than women. If this involves adipose tissue is unknown and was presently examined.

Subjects/Methods
AdipoIR (in vivo adipose insulin resistance index) was measured in 2344 women and 787 men. In 259 of the women and 54 of the men, insulin induced inhibition of lipolysis (acylglycerol breakdown) and stimulation of lipogenesis (glucose conversion to acylglycerols) were determined in subcutaneous adipocytes; in addition, basal (spontaneous) lipolysis was also determined in the fat cells. In 234 women and 115 men, RNAseq expression of canonical insulin signal genes were measured in subcutaneous adipose tissue. Messenger RNA transcripts of the most discriminant genes were quantified in 175 women and 109 men.

Results
Men had higher AdipoIR values than women but only when obesity (body mass index 30 kg/m2 or more) was present (p < 0.0001). The latter sex dimorphism was found among physically active and sedentary people, in those with and without cardiometabolic disease and in people using nicotine or not (p = 0.0003 or less). In obesity, adipocyte insulin sensitivity (half maximum effective hormone concentration) and maximal antilipolytic effect were tenfold and 10% lower, respectively, in men than women (p = 0.005 or less). Basal rate of lipolysis was two times higher in men than women (p > 0.0001). Sensitivity and maximum effect of insulin on lipogenesis were similar in both sexes (p = 0.26 and p = 0.18, respectively). When corrected for multiple comparison only RNAseq expression of insulin receptor substrate 1 (IRS1) was lower in men than women (p < 0.0001). The mRNA transcript for IRS1 was 60% higher in women than men (p < 0.0001).

Conclusions
In obesity, adipose tissue insulin resistance is more pronounced in men than in women. The mechanism involves less efficient insulin-mediated inhibition of adipocyte lipolysis, increased basal rate of lipolysis and decreased adipose expression of a key element of insulin signaling, IRS1.
Differential in vivo roles of Mpl cytoplasmic tyrosine residues in murine hematopoiesis and myeloproliferative disease
Authors: Behrens Kira , Kauppi Maria , Viney Elizabeth M. , Kueh Andrew J. , Hyland Craig D. , Willson Tracy A. , Salleh Liam , de Graaf Carolyn A. , Babon Jeffrey J. , Herold Marco J. , Nicola Nicos A. , Alexander Warren S. 
Published: March 2024

AbstractThrombopoietin (Tpo), which binds to its specific receptor, the Mpl protein, is the major cytokine regulator of megakaryopoiesis and circulating platelet number. Tpo binding to Mpl triggers activation of Janus kinase 2 (Jak2) and phosphorylation of the receptor, as well as activation of several intracellular signalling cascades that mediate cellular responses. Three tyrosine (Y) residues in the C-terminal region of the Mpl intracellular domain have been implicated as sites of phosphorylation required for regulation of major Tpo-stimulated signalling pathways: Mpl-Y565, Mpl-Y599 and Mpl-Y604. Here, we have introduced mutations in the mouse germline and report a consistent physiological requirement for Mpl-Y599, mutation of which resulted in thrombocytopenia, deficient megakaryopoiesis, low hematopoietic stem cell (HSC) number and function, and attenuated responses to myelosuppression. We further show that in models of myeloproliferative neoplasms (MPN), where Mpl is required for pathogenesis, thrombocytosis was dependent on intact Mpl-Y599. In contrast, Mpl-Y565 was required for negative regulation of Tpo responses; mutation of this residue resulted in excess megakaryopoiesis at steady-state and in response to myelosuppression, and exacerbated thrombocytosis associated with MPN.
A review of real-world evidence on preemptive pharmacogenomic testing for preventing adverse drug reactions: a reality for future health care
Authors: Chenchula Santenna , Atal Shubham , Uppugunduri Chakradhara Rao S 
Published: March 2024

AbstractAdverse drug reactions (ADRs) are a significant public health concern and a leading cause of hospitalization; they are estimated to be the fourth leading cause of death and increasing healthcare costs worldwide. Carrying a genetic variant could alter the efficacy and increase the risk of ADRs associated with a drug in a target population for commonly prescribed drugs. The use of pre-emptive pharmacogenetic/omic (PGx) testing can improve drug therapeutic efficacy, safety, and compliance by guiding the selection of drugs and/or dosages. In the present narrative review, we examined the current evidence of pre-emptive PGx testing-based treatment for the prevention of ADRs incidence and hospitalization or emergency department visits due to serious ADRs, thus improving patient safety. We then shared our perspective on the importance of preemptive PGx testing in clinical practice for the safe use of medicines and decreasing healthcare costs.