bluuebunny/crossref_metadata_2025_split huggingface dataset:
Decreased incidence of renal tumors in DMN treated Balb/C mice after orchiectomy
Authors: Noronha Reynold F. X. 
Published: February 2007

AbstractDimethylnitrosamine (DMN) induced a significant incidence (45.5%) of kidney epithelial tumors in adult male Balb/C mice. The proportion of mice with renal tumors orchiectomized after DMN injection was reduced to 25.6%; whereas the proportion of tumor bearing animals at other sites, such as lung, liver, and lymphatic tissue, increased compared to intact DMN treated animals and controls. This experiment confirms other studies in rats and mice showing that androgens play a role in initiation and progression of nitrosamine induced renal cancer, paralleling the finding of increased male susceptibility in human renal cancer.
Acinic cell tumor of the palate
Authors: Deutsch Harold L. , Millard D. Ralph 
Published: February 2007

AbstractA rare acinic cell carcinoma of the soft palate is reported and its potential for recurrence and metastasis discussed. A wide ablation created a speech‐crippling defect that was reconstructed with an island flap from the opposite side and a pharyngeal flap for nasal lining and an island flap from the same side for oral cover. Speech is again normal.
Radical mastectomy for operable breast cancer
Authors: Freund H. , Durst A. L. , Grover N. B. , Komissar G. , Peterburg I. , Saltz N. J. 
Published: February 2007

AbstractThe experience with radical mastectomy in the treatment of 152 cases of operable breast cancer at the Hadassah University Hospital has been analyzed. An overall 5 year survival of 75% and a 10 year survival of 62% are reported and compared with results from other methods of treatment. Based on the excellent survival rates achieved and the low incidence of local recurrence (9.8%), the present study suggests that radical mastectomy is still the most suitable surgical procedure in the treatment of operable breast cancer.
The role of stress factors in the postoperative course of patients with rectal cancer
Authors: Genzdilov A. V. , Alexandrin G. P. , Simonov N. N. , Evtjuhin A. I. , Bobrov U. F. 
Published: February 2007

AbstractThe authors studied 82 patients with rectal cancer who underwent radical surgical treatment at the N. N. Petrov Oncological Research Institute of the Ministry of Health of the USSR in 1974–1975. They defined the markedness of patients' psychogenic disturbances in the pre‐ and postoperative period and measured the level of catecholamines in urine and that of 11‐oxycorticosteroids in blood. The findings showed the highest frequency of postoperative complications (68%) in the group of patients who evidenced severe psychic reactions when they were admitted to the clinic. These data correlated with a higher level of catecholamines in the urine and of 11‐oxycorticosteroids in the blood before surgery, and with a marked decrease of catecholamine exeretion on the sixth day after the operation. This may indicate sympathetic‐adrenal system exhaustion and play a certain part in the development of postoperative complications.
Squamous cell carcinoma of the esophagus: A study of 153 cases
Authors: Takita Hiroshi , Vincent Ronald G. , Caicedo Victor , Gutierrez Alberto C. 
Published: February 2007

AbstractThe incidence of esophageal carcinoma in the United States is relatively low; total estimated cases annually are about 7,000 (Ca, 1975). The overall cure rate, however, is about the worst among all the malignant diseases and is reported to be 3% (Ca, 1975).We reviewed cases of squamous cell carcinoma of the esophagus treated at Roswell Park Memorial Institute to understand the clinicopathologic features in order to improve our therapeutic results.
Serum polyamine alterations in surgical patients with colorectal carcinoma
Authors: Nishioka Kenji , Romsdahl Marvin M. , McMurtrey Marion J. 
Published: February 2007

AbstractPolyamines, by virtue of their regulatory role in the cellular synthesis of DNA, RNA, and protein, are potential indicators of malignant growth. In view of this, serum polyamine levels of patients with colorectal carcinoma or benign bowel disease were examined. Of 53 patients with colorectal carcinoma, 35 (66%) showed elevations of 1 or more polyamines. Nine patients with benign bowel disease (villous adenoma, Gardner's syndrome, familial polyposis, and diverticulitis) showed normal serum polyamine levels except 1 patient with a villous adenoma. Patients with colorectal carcinoma were designated stage A, B, C, or D depending on the progression of their disease. All patients classified as D showed elevation of 1 or more polyamines. Serum polyamines became elevated following surgery in patients with colorectal carcinoma as well as those with benign bowel diseases, suggesting a relationship to the surgical procedure. Preliminary longitudinal studies of patients with colorectal carcinoma (B stage) undergoing curable surgical procedures show normal polyamine levels and no evidence of disease at 15 months.
Estrogen receptor levels in hormonally progressive mammary tumors
Authors: Bronn Donald G. , Kim Untae , Divecchia Loretta , Kibbey William E. , Minton John P. 
Published: February 2007

AbstractTumor samples from 4 different stages of hormonal progression in the MT‐W9 series of rat mammary tumors were analyzed for estrogen receptors by the dextran‐coated charcoal method in order to further explore the clinical implications of the estrogen receptor assay. The findings indicate that although the presence of estrogen receptors is not an exclusive characteristic of hormonal dependency, their absence is indicative of a later stage of hormonal progression which might be of more immediate clinical consequence because hormonally autonomous tumors have faster growth rates than hormonally dependent tumors. It is also suggested that it may be necessary to initiate chemotherapy as an adjuvant to endocrine therapy for metastatic breast cancer patients with hormonally dependent tumors in order to avoid the eventual proliferation of hormonally autonomous tumor cells which are present in hormonally dependent tumors.
Nonsurgical treatment of pelvic rhabdomyosarcoma: A case report
Authors: Brecher Martin L. , Freeman Arnold I. , Thomas P. R. M. , Sinks Lucius F. 
Published: February 2007

AbstractA 2 ½‐year‐old male child with rhabdomyosarcoma of the prostate was treated with radiation to the pelvis, consisting of 5,600 rads in 7 ½ weeks, and combination chemotherapy of Vincristine and Actinomycin D. Surgery had been refused. The child is alive and disease‐free more than 5 years after diagnosis, and over 2 years following the cessation of all therapy. Recent advances in radiotherapy and adjuvant chemotherapy have significantly improved the outlook in this aggressive childhood neoplasm and have made a less aggressive and less mutilating surgical approach often desirable. This, in turn, holds out the prospect of improved quality of survival in children so afflicted.
Cryosurgical treatment of aneurysmal bone cysts
Authors: Oeseburg Harry B. , Rogge Carl W. L. , Koops Heimen Schraffordt , Oldhoff Jan 
Published: February 2007

AbstractAn aneurysmal bone cyst is a benign, locally aggressive bone process which frequently recurs after excochleation. Excochleation can be extended without loss of bone tissue by making use of cryosurgery. This combined technique was used in the treatment of 5 patients, without complications. None of the patients described had a demonstrable recurrence 12–60 (average 35) months after this combined therapy.
The usefulness of pretreatment DNCB in 85 patients with squamous cell carcinoma of the upper aerodigestive tract
Authors: Gilbert Harvey A. , Kagan A. Robert , Miles John , Flores Luis , Nussbaum Herman , Rao Aroor R. , Chan Paul 
Published: February 2007

AbstractPretreatment DNCB skin testing and absolute lymphocyte counts were studied in 85 consecutive head and neck cancer patients. All patients were treated primarily with radiation therapy alone or combined radiation plus surgery. The results of DNCB testing and absolute lymphocyte counts were not sufficiently predictive of outcome, (no evidence of disease after 2 years) to be useful in making treatment decisions on an individual patient. This applied to the good prognosis (T1, T2, N0‐N3) and poor prognosis (T3, T4, N0‐N3) groups.
Response of intramuscular walker 256 rat tumor to sustained‐release cyclophosphamide and ara‐c capsules
Authors: Fu J. C. , Moyer D. L. , Cuevas J. , Cummings L. , Eaton A. , Elshire D. 
Published: February 2007

AbstractRandomly bred Sprague‐Dawley rats with the intramuscular form of Walker 256 tumor growing in the right thigh region were treated with sustained‐release cyclophosphamide capsules as well as with cytosine arabinoside capsules. A disk‐shaped capsule was implanted subcutaneously adjacent to the tumor mass. Tumor regression, weight gain, and prolongation of lifespan were observed in animals treated with cyclophosphamide capsules of 10 mg or 20 mg total drug content each. However, the Walker 256 intramuscular tumor did not respond to ARA‐C capsules implanted, and the animals died at the same rate as the controls, with large ulcerated tumor masses and some metastasis. The in vitro diffusion data of ARA‐C capsules is shown. Gross and histological changes associated with cyclophosphamide administered in this manner are reported.
Anal carcinoma: Basic concepts and management
Authors: Hintz Brace L. , Charyulu Komanduri K. N. , Sudarsanam Anam 
Published: February 2007

AbstractSurgery has been the mainstay in the management of anal carcinoma. However, anal carcinomas are reasonably sensitive to ionizing radiation. By appropriate combinations of external radiation beams and interstitial implantation techniques, curative therapy with preservation of anal continence can be rendered by radiation alone. Sufficient radiation dose to the draining lymph nodes, both intraabdominal and inguinal, along with intensified dose to the primary lesions, is required for high cure and low complication rates.
Effect of surgery on granulocyte/macrophage colony‐stimulating factor
Authors: Reines Howard D. , Foster Roger S. 
Published: February 2007

AbstractEighteen surgical patients were studied to determine the effect of anesthesia (general or spinal) and surgery on serum and urinary colony‐stimulating factor(s) (CSF). CSF is a leukopoietin that stimulates proliferation of macrophages and granulocytes from bone marrow precursor cells. CSF was assayed by adding aliquots of serum or urine to semisolid agar cultures of bone marrow cells and scoring the number of colonies developing after 7 days of incubation. In all but 1 case, a 3‐ to 30‐fold increase in the 24 hour excretion of urinary CSF was seen on the day of surgery and the first postoperative day. CSF urinary excretion began declining toward normal by the second postoperative day. A parallel increase in granulocyte count, a delayed rise in monocytes, and a decline in absolute lymphocyte counts were also observed.The data suggest that immediately postoperatively there may be a strong stimulus to granulocyte/macrophage proliferation. More rapidly proliferating cells would be anticipated to have increased vulnerability to toxicity from cell cycle‐active chemotherapeutic agents.
Lung resection for metastatic osteogenic sarcoma
Authors: Huang Ming N. , Takita Hiroshi , Douglass Harold O. 
Published: February 2007

AbstractOsteogenic sarcoma, excluding the paraosteal osteosarcoma, has a grave prognosis, half of the patients dying within 1 year following ablative surgery of the primary lesion. Once pulmonary metastasis is detected, most patients do not survive more than 3 years. Various attempts by investigators to prolong patient survival, including surgery, chemotherapy, immunotherapy, radiation therapy, and combined modalities, have met with some success. This report is a summary of 13 patients who underwent lung resections and received adjuvant chemo‐ and/or immunotherapy for metastatic osteogenic sarcoma in our institute in the past 7 years.
Larynx cancer: A therapeutic policy at the Madras cancer institute
Authors: Rangakumar G. , Shanta V. 
Published: February 2007

AbstractWe studied 145 cases of larynx cancer in relation to their etiology, methods of treatment, and results. It was found that better results were obtained with a combination of radiotherapy and surgery. Any postradiational edema of the larynx should subside within 3 months. If this edema persists or progresses, it always means residual disease in the submucosal plane. We have now improved our results by using intravenous Bleomycin concurrently.
Angiographic features in tubular‐papillary adenocarcinoma of the kidney
Authors: Choi S. , Bae C. 
Published: February 2007

AbstractAngiography and nephrotomography are essential in evaluation of avascular or hypovascular space occupying lesions of the kidney. Ultrasound adds another dimension in differentiating solid from cystic masses. Two cases of tubular‐papillary adenocarcinoma were reported. Their angiographic findings consisted of a few neovascularities. Nephrotomography and ultrasonography in the second case showed a solid mass.
An evaluation of the surgical management of melanoma of the brain
Authors: Bremer Alfonso M. , West Charles R. , Didolkar Mukund S. 
Published: February 2007

AbstractThirty‐two patients with histologically proved metastatic malignant melanoma of the brain were evaluated. Intracranial surgery was performed in 19 and was considered not indicated in 13 patients. Following intracranial surgery, satisfactory improvement in neurologic deficits was observed in 14 (74%) patients. The median survival after occurrence of brain metastases was 5–6 months (1 – 15 months) for the surgical group; and for the nonsurgical group, patients with multiple brain metastases and multiple visceral involvement did not survive beyond a median of 1 month (range 0.5–6 months). Intratumor hemorrhage with substantial intracerebral hematoma was present in 7 (41%) out of 17 craniotomies. The overall incidence of intratumor hemorrhage found at autopsy was 59% for the entire series. Among ail the cases with intratumor hemorrhage, only 2 patients who received chemotherapy after craniotomy developed thrombocytopenia with fatal intracranial hemorrhage. The latter cause‐and‐effect correlation could not be assessed in the other patients.As a result of this retrospective study, we have observed that patients with malignant melanoma and evidence of single brain metastasis without multiple visceral involvement seemed to benefit more from palliative surgery. Moreover, intratumor hemorrhage was a frequent occurrence and should be considered in the differential diagnosis of a patient with malignant melanoma and rapid deterioration of neurologic deficits.
Intermittent occlusion of the abdominal aorta: A conceptual approach in treating below‐diaphragm tumors (a preliminary report)
Authors: Pascal Oscar , Wajsman Zew , Jennings E. C. 
Published: February 2007

AbstractA modified form of tumor strangulation as a possible treatment modality is considered. Intermittent intra‐aortic occlusion by means of specially designed catheters and equipment is described. As a preliminary feasibility study, occlusion in non‐tumor‐bearing animals has begun, with projection for future human cases anticipated. Theoretical concepts of substances from the occlusion process resulting in cure and specific immunity in experimental animals are evaluated, and the belief in the development of modified antigens and antibodies as a consequence of restriction of a growing tumor's proliferating blood supply is discussed.
Preliminary observations on the use of corynebacterium parvum in patients with primary intracranial tumors: Effect on intracranial pressure
Authors: Selker Robert G. , Wolmark Norman , Fisher Bernard , Moore Pearl 
Published: February 2007

AbstractIt has been observed that patients with metastatic brain lesions developed neurologic symptoms when given Corynebacterium parvum. To obtain more information in patients with intracranial mass lesions, intracranial pressures (ICP) were measured or observed in six patients undergoing C. parvum therapy.All patients except two (one previously shunted, one recently operated) demonstrated a profound increase in ICP. It is presumed that either edema is formed within brain and tumor tissue (inasmuch as neurologic deterioration has not been observed in patients without an intracranial lesion) or transient increases in cerebral blood flow adversely alter an already compromised intracranial volume. Surgical decompression of tumor volume or use of Lasix® may abort this response to C. parvum infusion.
Three mice, two blind
Authors: Strong Leonell C. 
Published: February 2007

AbstractIn a closed colony of approximately one million mice which had been rigidly pedigreed (brother to sister) from a few original mice, three unusual mice have appeared. These three have obviously deviated from what would be expected according to the accepted laws of inbreeding geneity. Thus three unexpected incidences of increased variability have occurred three times in addition to the occasional appearance of new mutations (approximately one in 26,000 mice).The first mouse developed a sudden increase in susceptibility to spontaneous tumors of mammary origin. She became the mother of the well‐known C family used extensively in cancer research.The second mouse clearly exhibited, among clear‐cut altered biological characteristics, several somatic mutations, thus indicating an unstable genetic condition.The third mouse developed a highly significant capacity to regress and eliminate spontaneous tumor tissue.The conclusion is reached that unstable biological states arise occasionally during the process of inbreeding.
Surgical adjuvant immunotherapy for colorectal cancer
Authors: Enker Warren E. , Jacobitz Janet L. , Craft Karen , Wissler Robert W. 
Published: February 2007

AbstractOne hundred forty‐four Wistar‐Furth rats in 12 therapeutic groups have been studied in a long‐term comparison of the effectiveness of nonspecific immunotherapy with MER (methanol extraction residue) vs active‐specific immunotherapy with neuraminidase‐modified tumor cells. Six months after surgical adjuvant immunotherapy a 100% improvement in survival was achieved with MER immunotherapy compared to untreated control animals. In addition, the use of MER enhanced the value of active‐specific immunotherapy where both modalities were combined in sequence. The predicted value of MER‐BCG (Bacillus Calmette‐Guerin) for the immunotherapy of solid tumors was borne out by these results suggesting that present ongoing clinical trials of MER as adjuvant therapy for large bowel cancer should prove to be successful if properly controlled. The pattern of survival in these experiments suggests that surgical adjuvant immunotherapy is cytostatic rather than cytocidal, and implies the need for long‐term, repeated immunizations.
Leiomyosarcomas of the extremities: Angiography as a diagnostic aid
Authors: Park Jung Ja , Park Hyung Chan , Choi Sung H. 
Published: February 2007

AbstractThirteen cases of leiomyosarcomas of the extremities are reported. Most of the cases were operated on without information concerning benignancy or malignancy. Plain radiographs showed amorphous calcification in two cases. Three cases had angiographic study and all revealed malignant neovascularity. In no literature that we reviewed was angiography mentioned in the cases of leiomyosarcomas of the extremities. Venography alone has been done in many reported cases. The leiomyosarcoma of the extremities looks often benign but is notorious for local recurrences and distant metastases.
Chromosomal evidence for the transplantability of the shay chloroleukemia
Authors: Derelanko M. J. , Moorthy A. S. , Lobue J. , Meagher R. C. , Gordon A. S. , Mitra J. , Fredrickson T. N. 
Published: February 2007

AbstractChloroma cells, which were shown to contain the X and Y chromosomes, were used to induce Shay chloroleukemia (SCL) in female recipients. Karyotype analyses of leukemic myeloblasts which appeared in the peripheral blood of the female recipients during blast crisis demonstrated invariably the presence of the X and Y chromosomes. These results directly demonstrate that transmission of SCL is the result of donor cell colonization and therefore SCL can be considered a true transplantable leukemia. Reports by other workers of viral association with this dissease are discussed in light of our results.
Pancreas cancer — duct cell adenocarcinoma: Survival in relation to site, size, stage and type of therapy
Authors: Cubilla Antonio L. , Fitzgerald Patrick J. , Fortner Joseph G. 
Published: February 2007

AbstractThe records of 508 patients with cancer of the pancreas admitted to Memorial Hospital in New York from 1949 through 1972 were examined. Ten distinctive morphological types were delineated and the pathological features and response to various modes of therapy of the most common type — duct adenocarcinoma — were studied in 380 patients. Median survival was related to: the site of the cancer — it was longer with tumors of the head than those of the body or tail; the size of the tumor — cancers smaller than 3 cm were associated with over twice the survival of those with large tumors; the stage — stage I patients had over twice the survival of those of stages II and III; and the type of therapy employed. Actuarial survival rate at one year was: with no specific therapy, 0%; with chemotherapy, 1%; after palliative by‐pass surgery, 3%; following radiation therapy, 9%; and after all types of “curative” surgery, 21%. The only survivors at five years were in the “curative” surgery group, but these represented only 1% of all patients. Revolutionary changes in diagnosis and therapy will have to occur if significant increase in survival rate is to be achieved.
Retarded tumor growth and greater longevity in mice after fetal irradiation by 2450‐MHz microwaves
Authors: Preskorn Sheldon H. , Edwards William D. , Justesen Don R. 
Published: February 2007

AbstractIn the first of two studies, 48 mice of the conventional CFW strain were sham‐radiated or radiated in utero for 20 minutes daily by 2,450‐MHz microwaves at a dose rate, respectively, of 0 or 35 mW/g during days 11–14 of gestation. All 48 mice were implanted with a homogenate of a lymphoreticular cell sarcoma on the 16th day postpartum and then, commencing on the 19th day, they underwent a series of 36 daily exposures to the sham‐ or to the microwave‐radiation. Fetal exposure to radiation, which elevated dams colonic temperatures by an average of 2.24°C, was associated with a lower incidence of tumors (13% vs 46% for fetally sham‐radiated mice) as verified histologically at necropsy on the 93rd day postpartum. In the second study, 84 CFW mice received the four radiation treatments in utero; 60 mice were sham‐radiated in utero and served as controls. Postnatal radiation was not administered. All 144 mice were implanted with the homogenate on the 16th day postpartum and then were observed for nearly 36 months for development of palpable tumors and for longevity. Tumors initially developed at a lower rate in fetally radiated mice and 2.5 months after implantation the respective percentages of “takes” in sham‐ and microwave‐irradiated mice were comparable to those observed at termination of the first study. Subsequently the rate of tumor induction in radiated mice accelerated, and after the fourth month the final percentage of radiated mice with tumors (46%) slightly exceeded that of controls (40%). Both tumor‐bearing and tumor‐free animals that had been radiated as fetuses lived longer on the average than respective controls. Long‐term augmentation of immunocompetency by in utero hyperthermia is believed to be responsible for the delayed induction of tumors and for enhancement of survival.