bluuebunny/crossref_metadata_2025_split huggingface dataset:
Leaking Pipes Recharge Ground Water
Authors: Lerner David N. 
Published: May 2007

ABSTRACTWater is piped beneath cities in water mains, sewers, and storm drains. Most, if not all, of these pipe networks leak. Evidence from a ground‐water resources study for Lima, Peru and a slope stability study in Hong Kong is presented to show that leakage losses recharge ground water. The contribution of leakage to recharge is shown by ground‐water levels, ground‐water chemistry, and by water balance and ground‐water modeling studies. Estimates of the leakage quantities involved can be developed from water balance and modeling studies, and from analysis of conventional leakage detection tests carried out by water‐supply authorities. In Lima, about 40% of the average supply became recharge. Maximum areal rates of recharge for both cities were about 3000 mm/yr.
Philosophical Issues Arising from Experimental Economics
Authors: Ernst Zachary 
Published: May 2007

AbstractHuman beings are highly irrational, at least if we hold to an economic standard of ‘rationality’. Experimental economics studies the irrational behavior of human beings, with the aim of understanding exactly how our behavior deviates from the Homo economicus, as ‘rational man’ has been called. Insofar as philosophical theories depend upon rationality assumptions, experimental economics is the source of both problems and (at least potential) solutions to several philosophical issues. This article offers a programmatic and highly biased survey of some of these issues, with the hope of convincing the reader that experimental economics is well‐deserving of careful study by philosophers.
The Search for Neural Correlates of Consciousness
Authors: Hohwy Jakob 
Published: May 2007

AbstractThe science of consciousness begins with the search for the neural correlates of consciousness. I explain this notion and give examples of research in the field. I then discuss how differentconceptionsof consciousness may influence the search for the neural correlates. This includes the distinctions between access and phenomenal consciousness, and between conscious states and unified conscious fields, as well as phenomenological conceptions. Finally, I discuss what finding the neural correlates may imply for themetaphysicsof consciousness, in particular for the theory that conscious states are identical to brain states.
Changes in attitudes toward wildlife and wildlife meats in Hunan Province, central China, before and after the severe acute respiratory syndrome outbreak
Authors: YANG Daode , DAI Xiaofeng , DENG Yiping , LU Weiquan , JIANG Zhigang 
Published: May 2007

AbstractTwo surveys of opinions about wildlife conservation were carried out in Hunan Province, China, before and after the severe acute respiratory syndrome (SARS) epidemic. Hunan is the northern neighbor of Guangdong Province, where the first SARS case was reported. The custom of consuming wild meat was not common in Hunan 30 years ago. However, in recent years, consumption of wildlife such as snakes has spread to northern China. We handed out 1300 questionnaires between 22 February and 10 May 2002, before the SARS epidemic. Survey sites included the provincial capital, major cities, towns, and villages in Hunan. Another 1300 questionnaires were distributed between 10 March and 10 May 2004, after the SARS epidemic. The 2004 survey covered the same sites as the 2002 survey. Questionnaire recovery rates for the 2002 and 2004 surveys were 81.2% and 84.6%, respectively. The valid return rate was 73.0%. Frog, snake, hare, and pheasant were the wild meats most frequently eaten by local people. At the time of the first survey, more than 80% of interviewees claimed to have eaten frogs. That number had reduced to 60% by the time of the second survey. Monkey, Chinese pangolin, and bear paw were the wild meats least frequently eaten. Although palm civet was suspected to be the carrier of SARS, it was interesting to note that, after the SARS epidemic, the proportion of people surveyed who ate palm civets had declined only slightly. The results of the surveys indicate a low level of conservation consciousness; however, after the SARS and bird flu epidemics, there were obvious changes in the conservation consciousness of people in Hunan Province. We recommend some measures that could be taken to change the habits of people who consume wildlife.
Temporal Phase Pluralism*
Authors: BRADDON‐MITCHELL DAVID , WEST CAROLINE 
Published: May 2007

Some theories of personal identity allow some variation in what it takes for a person to survive from context to context; and sometimes this is determined by the desires of person‐stages or the practices of communities.This leads to problems for decision making in contexts where what is chosen will affect personal identity.‘Temporal Phase Pluralism’ solves such problems by allowing that there can be a plurality of persons constituted by a sequence of person stages. This illuminates difficult decision making problems when persons have to choose between different life‐altering choices.
Postmodernism's Use and Abuse of Nietzsche
Authors: GEMES KEN 
Published: May 2007

I focus on Nietzsche's architectural metaphor of self‐construction in arguing for the claim that postmodern readings of Nietzsche misunderstand his various attacks on dogmatic philosophy as paving the way for acceptance of a self characterized by fundamental disunity. Nietzsche's attack on essentialist dogmatic metaphysics is a call to engage in a purposive self‐creation under a unifying will, a will that possesses the strength to reinterpret history as a pathway to “the problem that we are”. Nietzsche agrees with the postmodernists that unity is not a pre‐given, however he would disavow their rejection of unity as a goal. Where the postmodernists celebrate “the death of the subject” Nietzsche rejects this valorization of disunity as a form of Nihilism and prescribes the creation of a genuine unified subjectivity to those few capable of such a goal. Postmodernists are nearer Nietzsche's idea of the Last Man than his idea of the Overman.I define postmodernism as incredulity towards meta‐narratives.Jean‐François Lyotard. The Postmodern Condition.When the past speaks it always speaks as an oracle: only if you are an architect of the future and know the present will you understand it.Friedrich Nietzsche, “On the Use and Abuse of History for Life.”
Practical Identities and Autonomy: Korsgaard's Reformation of Kan's Moral Philosophy
Authors: GOWANS CHRISTOPHER W. 
Published: May 2007

Kant has long been taxed with an inability to explain the detailed normative content of our lives by making universalizability the sole arbiter of our values. Korsgaard addresses one form of this critique by defending a Kantian theory amended by a seemingly attractive conception of practical identities. Identities are dependent on the contingent circumstances of each person's world. Hence, obligations issuing from them differ from Kantian moral obligations in not applying to all persons. Still, Korsgaard takes Kantian autonomy to mean the normativity of all obligations is rooted in universalizability. The wealth of values informing our lives is thus said to be accommodated within a Kantian framework.After briefly explaining Korsgaard's understanding of practical identities and their role in her reformation of Kant's moral philosophy, I argue that she gives an inadequate explanation of how the obligations that arise from a person's practical identities derive their authority from the person's will. I then consider how her position might be developed to meet this objection in accordance with her allegiance to “constructivism” and I argue that the epistemic commitments of people's actual identities makes it unlikely that such a development could preserve Kantian autonomy as she interprets it.
The Good Life: A Defense of Attitudinal Hedonism
Authors: FELDMAN FRED 
Published: May 2007

What makes a life go well for the one who lives it? Hedonists hold that pleasure enhances the value of a life; pain diminishes it. Hedonism has been subjected to a number of objections. Some are (a) based on the claim that hedonism is a form of “mental statism”. Others are (b) based on the claim that some pleasures are base or degrading. Yet others are (c) based on the claim that when a bad person enjoys a pleasure, his receipt of that pleasure seem not to make the world better.It is important to keep in mind that hedonism is a theory about the value of a person's life for the person who lives it, and not for the world or for others. It is also important to distinguish between sensory hedonism and attitudinal hedonism.“Desert Adjusted Intrinsic Attitudinal Hedonism” appears to be immune to objections (a) and (b). A variant appears to be immune to all of them. Perhaps it is the answer to the question about the value of a life.
Islam and Loyalty in the Saudi Hijaz, 1926-1939
Authors: Ochsenwald William 
Published: May 2007

AbstractThis article examines the complex process by which the Hijaz and its holy cities were partially integrated with the central province of Najd to create the beginning of unity for Saudi Arabia even before the advent of large oil revenues drastically affected the Kingdom. Religion was one of the most important elements in this process as seen in the successful Saudi management of the pilgrimage and the rigorous application of numerous regulations designed to forbid evil and promote good while also securing the rule of the Saudi dynasty. The Najdi ulamā's extreme zeal offended many Hijazis, but it was ameliorated by the ruling family's more lenient implementation of policies intended to lessen the severity of the now-dominant interpretation of Islam. Saudi rule also depended upon such secular factors as military capacity, the lack of viable alternatives, and attempts to unify social customs and identity. By 1939 Hijazis and Najdis still regarded themselves as separate, with Najdi control often resented, but most of the people living in the urban centers had accepted Saudi political rule while still remaining somewhat unconvinced about many of the religious and social changes associated with it.
Induction of lung lesions in Wistar rats by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and its inhibition by aspirin and phenethyl isothiocyanate
Authors: Ye Bo , Zhang Yu-Xia , Yang Fei , Chen Hong-Lei , Xia Dong , Liu Ming-Qiu , Lai Bai-Tang 
Published: May 2007

Abstract

Background
The development of effective chemopreventive agents against cigarette smoke-induced lung cancer could be greatly facilitated by suitable laboratory animal models, such as animals treated with the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). In the current study, we established a novel lung cancer model in Wistar rats treated with NNK. Using this model, we assessed the effects of two chemopreventive agents, aspirin and phenethyl isothiocyanate (PEITC), on tumor progression.

Methods
First, rats were treated with a single-dose of NNK by intratracheal instillation; control rats received iodized oil. The animals were then sacrificed on the indicated day after drug administration and examined for tumors in the target organs. PCNA, p63 and COX-2 expression were analyzed in the preneoplastic lung lesions. Second, rats were treated with a single-dose of NNK (25 mg/kg body weight) in the absence or presence of aspirin and/or PEITC in the daily diet. The control group received only the vehicle in the regular diet. The animals were sacrificed on day 91 after bronchial instillation of NNK. Lungs were collected and processed for histopathological and immunohistochemical assays.

Results
NNK induced preneoplastic lesions in lungs, including 33.3% alveolar hyperplasia and 55.6% alveolar atypical dysplasia. COX-2 expression increased similarly in alveolar hyperplasia and alveolar atypical dysplasia, while PCNA expression increased more significantly in the latter than the former. No p63 expression was detected in the preneoplastic lesions. In the second study, the incidences of alveolar atypical dysplasia were reduced to 10%, 10% and 0%, respectively, in the aspirin, PEITC and aspirin and PEITC groups, compared with 62.5% in the carcinogen-treated control group. COX-2 expression decreased after dietary aspirin or aspirin and PEITC treatment. PCNA expression was significantly reduced in the aspirin and PEITC group.

Conclusion
(1) A single dose of 25 mg/kg body weight NNK by intratracheal instillation is sufficient to induce preneoplastic lesions in Wistar rat lungs. (2) COX-2 takes part in NNK-induced tumorigenesis but is not involved in proliferation. (3) Aspirin and PEITC have protective effects in the early stages of tumor progression initiated by NNK.
An exploration of key information models and their relationships in global manufacturing decision support
Authors: Liu Shaofeng , Young R I M 
Published: May 2007

Global manufacturing businesses are beginning to benefit from the information and knowledge support provided by modern IT tools such as Product Lifecycle Management (PLM), Enterprise Resource Planning (ERP), and Customer Relations Management (CRM). Many types of information and knowledge, from customer requirements through product information to global enterprise manufacturing capability are involved in global manufacturing decisions. Understanding the appropriate structures and relationships for this information and knowledge is a significant issue if effective wide-ranging support is to be provided. This paper focuses on global manufacturing decision support and explores three key types of information and knowledge relationship: (a) relationships between information and knowledge elements within a single information and knowledge model; (b) relationships between different information and knowledge models at one organizational level; (c) relationships between different information and knowledge models at different organizational levels. The corresponding information and knowledge structures have been presented with Unified Modelling Language (UML) to show the multiplicity of relationship required, and these are explored with an experimental system based on Rational Unified Process, Visual C++, and object-oriented DBMS ObjectStore. A case study has been pursued to explore the application of the information and knowledge models to a real industry environment.
Position control of flexible manipulator using non-linear H∞ with state-dependent Riccati equation
Authors: Shawky A. M. , Ordys A. W. , Petropoulakis L , Grimble M. J. 
Published: May 2007

The paper is concerned with the control of the tip position of a single-link flexible manipulator. The non-linear model of the manipulator is derived and tested, assuming the number of model shape functions to be two. It is known that the assumed modes method introduces uncertainty to the model by neglecting higher-order dynamics. There are other sources of uncertainty, such as friction. In addition, the model is non-linear. Therefore, for the next task, which is the controller design, the H∞ approach is proposed to deal efficiently with uncertainties, and the non-linear nature of the problem is addressed by the use of the state-dependent Riccati equation (SDRE) technique. Following the SDRE approach, the state-feedback non-linear control law is derived, which minimizes a quadratic cost function. This solution is then mapped into the H∞ optimization problem. The resulting control law has been tested with the simulation model of the flexible manipulator and the results are discussed in the paper.
Early hyponatraemia after pituitary surgery: cerebral salt-wasting syndrome
Authors: Guerrero R , Pumar A , Soto A , Pomares M A , Palma S , Mangas M A , Leal A , Villamil F 
Published: May 2007

Hyponatraemia is a common complication in patients undergoing neurosurgery. It can be caused either by the syndrome of inappropriate secretion of antidiuretic hormone or by the cerebral salt-wasting syndrome (CSWS). CSWS frequently occurs in patients suffering from subarachnoid haemorrhage and brain injury, but it is rare after pituitary tumour surgery. However, this diagnostic possibility should be considered as these disorders require specific treatment and have different prognoses.
In this article, we present a case of acute and early hyponatraemia caused by CSWS after pituitary tumour surgery. We also revise the aetiology, mechanisms, differential diagnosis and treatment of hyponatraemia after pituitary surgery.
Changes in calf muscle elasticity in hypogonadal males before and after testosterone substitution as monitored by magnetic resonance elastography
Authors: Brauck Katja , Galbán Craig J , Maderwald Stefan , Herrmann Burkhard L , Ladd Mark E 
Published: May 2007

Purpose: We sought to determine whether differences in muscle elasticity between healthy age-related controls and patients with hypogonadism could be measured by a new, non-invasive method termed magnetic resonance elastography (MRE).
Materials and methods: Twelve hypogonadal (21–68 years) and twenty-seven healthy age-related men (20–76 years) were examined. In the hypogonadism group, serum testosterone levels were compared and MRE was conducted prior to and after 6 months of therapy in 6 of the 12 patients. MRE was performed by mechanically exciting the soleus muscle that was used because of its uniformly distributed muscle fibers, size, and accessibility, with a custom designed piezoelectric-actuator using a modified phase-contrast sequence. For mechanical excitation the actuator lever was placed on the anterior surface of the calf. The subjects had to maintain a force of 0–20% of their maximum voluntary contraction against a home-built footplate that was mounted on the MR table. All images were phase unwrapped and reconstructed into shear modulus elastograms using the local frequency estimation technique.
Results: Testosterone levels were significantly higher after 6 months of treatment. A statistical difference in the shear modulus was observed prior to and after 6 months of testosterone therapy and was nearly the same as in the healthy age-related control group.
Conclusion: MRE seems to be a promising technique for the evaluation of therapeutic effects in patients with hypogonadism and possibly in other diseases with muscular effects.
Superiority of skinfold measurements and waist over waist-to-hip ratio for determination of body fat distribution in a population-based cohort of Caucasian Dutch adults
Authors: Ketel Iris J G , Volman Mariken N M , Seidell Jacob C , Stehouwer Coen D A , Twisk Jos W , Lambalk Cornelis B 
Published: May 2007

Objective: To determine which anthropometric measurement is the most reliable alternative for fat distribution as measured by dual-energy X-ray absorptiometry (DXA).
Design: Population-based survey carried out in Amsterdam, The Netherlands.
Subjects and methods: A total of 376 individuals (200 women) with a mean age of 36.5 years and mean body mass index (BMI) of 24.0 (±3.1) kg/m2 underwent various anthropometric and DXA measurements of central (CFM) and peripheral fat mass (PFM). Furthermore, for the assessment of apple-shaped body composition, CFM-to-PFM ratio was calculated. Anthropometric measurements were waist and hip circumference, waist-to-hip ratio (WHR), BMI, waist/length and the skinfold thickness of biceps, triceps, suprailiacal (SI), subscapular (SS) and upper leg. We determined whether equations of combined anthropometrics were even more reliable for the assessment of fat mass.
Results: In both women and men, reliable alternatives for CFM are central skinfolds and waist (Pearson’s correlation (r) ≥ 0.8). Peripheral skinfolds are the best predictors of PFM (r ≥ 0.8). In contrast, WHR correlated only marginally with any of the DXA measurements. Equations based on several anthropometric variables correlate with CFM even better (R2 ≥ 0.8). CFM-to-PFM ratio has the highest correlation with the ratio (SS+SI)/BMI in women (r = 0.66) and waist/length in men (r = 0.71). Equations are reasonable alternatives of CFM-to-PFM ratio (R2 ≥ 0.5).
Conclusion: Waist and skinfolds are reliable alternatives for the measurement of body fat mass in a cohort of Caucasian adults. WHR is not appropriate for the measurement of fat distribution.
Co-localisation of the Kir6.2/SUR1 channel complex with glucagon-like peptide-1 and glucose-dependent insulinotrophic polypeptide expression in human ileal cells and implications for glycaemic control in new onset type 1 diabetes
Authors: Nielsen Lotte B , Ploug Kenneth B , Swift Peter , Ørskov Cathrine , Jansen-Olesen Inger , Chiarelli Francesco , Holst Jens J , Hougaard Philip , Pörksen Sven , Holl Reinhard , de Beaufort Carine , Gammeltoft Steen , Rorsman Patrik , Mortensen Henrik B , Hansen Lars , _ _ 
Published: May 2007

Objective: The ATP-dependent K+-channel (KATP) is critical for glucose sensing and normal glucagon and insulin secretion from pancreatic endocrine α- and β-cells. Gastrointestinal endocrine L- and K-cells are also glucose-sensing cells secreting glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotrophic polypeptide (GIP) respectively. The aims of this study were to 1) investigate the expression and co-localisation of the KATP channel subunits, Kir6.2 and SUR1, in human L- and K-cells and 2) investigate if a common hyperactive variant of the Kir6.2 subunit, Glu23Lys, exerts a functional impact on glucose-sensing tissues in vivo that may affect the overall glycaemic control in children with new-onset type 1 diabetes.
Design and methods: Western blot and immunohistochemical analyses were performed for expression and co-localisation studies. Meal-stimulated C-peptide test was carried out in 257 children at 1, 6 and 12 months after diagnosis. Genotyping for the Glu23Lys variant was by PCR-restriction fragment length polymorphism.
Results: Kir6.2 and SUR1 co-localise with GLP-1 in L-cells and with GIP in K-cells in human ileum tissue. Children with type 1 diabetes carrying the hyperactive Glu23Lys variant had higher HbA1C at bdiagnosis (coefficient = 0.61%, P = 0.02) and 1 month after initial insulin therapy (coefficient = 0.30%, P = 0.05), but later disappeared. However, when adjusting HbA1C for the given dose of exogenous insulin, the dose-adjusted HbA1C remained higher throughout the 12 month study period (coefficient = 0.42%, P = 0.03).
Conclusions: Kir6.2 and SUR1 co-localise in the gastrointestinal endocrine L- and K-cells. The hyperactive Glu23Lys variant of the KATP channel subunit Kir6.2 may cause defective glucose sensing in several tissues and impaired glycaemic control in children with type 1 diabetes.