bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of mouse hepatitis virus on the growth of human melanoma in the peritoneal cavity of the athymic mouse
Authors: Akimaru Koho , Stuhlmiller Gary M. , Seigler H. F. 
Published: February 2007

AbstractMouse hepatitis virus (MHV) infection was found in 15 of 40 athymic mice (Balb/c nu/nu) used in an experimental model designed to study the effect of cell mediated immunity on target human melanoma cells growing in the peritoneal cavity.Most non‐MHV‐infected mice died of peritoneal tumor within predictable periods following injection of the melanoma cells. Twelve of 15 MHV‐infected mice which showed either poor or no tumor growth died of MHV infection, whereas only 3 showed good tumor growth. Peritoneal marcrophages in the ascites from the MHV‐infected mice were greatly reduced in number compared to those in the ascites from the non‐MHV‐infected mice. Although the fibrohistiocytic reaction was more prominent in the MHV‐infected mice, other aspects of spleen and lymph node lymphocytic reactions exhibited no remarkable differences between the two groups. The possible mechanisms whereby MHV infection influences tumor growth in nude mice are discussed.
Estradiol‐3‐dansylate used as a fluorescent histochemical stain, a possible prognostic aid for nondisseminating prostatic carcinoma
Authors: van Dalen Johan P. R. 
Published: February 2007

AbstractTransperineal biopsies of prostate carcinomas were histochemically stained with estradiol‐3‐dansylate, a fluorescent stain. About half of the carcinomas were stainable but carcinomas with distant metastasis showed a lower staining percentage than carcinomas without distant metastasis. The combination of a positive estradiol‐3‐dansylate staining and a well‐to‐moderate differentiation of the tumor seems to indicate a low chance of developing metastasis in the future. If this correlation could be confirmed in following studies, it would mean that about one‐third of patients with localized prostatic carcinoma may be indicated by a transperineal biopsy with this method, as having a low risk for future metastasis.
Murine erythropoietin in ascitic fluid
Authors: Fredrickson T. N. , Lobue J. , Camiscoli J. F. , Gordon A. S. , Spector D. 
Published: February 2007

AbstractAdministration of 0.2 ml of a 1.25% solution of phenylhydrazine (PHZ) and 500 rads of X‐irradiation to BALB/c mice produced a prompt and severe reduction to hematocrit with a resultant increase in plasma levels of erythropoietin (Ep). By also giving mice treated with PHZ and irradiation an ascites from of a transplantable sarcoma, the amount of recoverable material rich in Ep could be greatly increased because ascitic fluid contained levels of Ep comparable to plasma.
Aneurysmal bone cyst of the mandible: Report of a case
Authors: Saltzman Eric I. , Jun Moo Young 
Published: February 2007

AbstractAneurysmal bone cysts are rare lesions, particularly in the craniofacial bones. After a comprehensive review of the English literature, the fifty fifth case occurring in the craniofacial area, and the twentieth in the mandible is reported. Cryosurgery is recommended as the treatment of choice in the head and neck area because of the low recurrence rate, the excellent cosmetic and functional results, and the lack of untoward sequelae in the long‐term.
Ultrastructural study of membrane glycocalyx in primary and metastatic human and rat mammary carcinoma
Authors: Ghosh Luna , Nassauer Joyce , Faiferman Isidore , Ghosh Bimal C. 
Published: February 2007

AbstractThe glycocalyx of primary and metastatic tumors was compared by ruthenium red staining and electron microscopy. Two systems were studied: human primary and metastatic breast tumors and rat primary and metastatic mammary carcinomas. A considerable diminution in the amount of glycocalyx was detected in both systems when primary tumors were compared with metastases. These results are consistent with observations of others showing that metastatic tumors shed glycoprotein antigens to the circulation; this may provide an immune escape mechanism for tumor cells, allowing their dissemination.
Hormone receptors in male breast carcinoma
Authors: Ruff Stanley J. , Bauer John E. , Keenan Edward J. , Moseley H. Stephens , Fletcher William S. 
Published: February 2007

AbstractIt is well established that approximately 60% of female breast cancers contain estrogen receptors (ER+). The hormonal receptor status of male breast cancers remains relatively unknown. Tumor tissue from 14 patients has been reviewed at the University of Oregon Health Sciences Center. Specimens of all 14 patients were ER+ with a range of 5.5 to 374 fmol/mg protein. Eight of 12 patients had tumors which also contained progesterone receptors (PR+) with a range of 42 to 1852 fmol/mg protein.Nine patients were treated by modified radical mastectomy, two by radical mastectomy, one by simple mastectomy, and two by biopsies only. Twelve patients remain free of disease with a mean follow‐up of less than 2 years. The two patients who developed metastases both responded to endocrine ablation by orchiectorny and subsequent adrenalectomy.These data suggest that male breast cancer is highly endocrine sensitive and that endocrine ablation can play an integral part in those men unfortunate enough to develop disseminated disease.
Malignant thymoma in an eight‐month‐old boy
Authors: Deshpande Ganesh N. , Fisher John E. , Jewett Theodore C. , Freeman Arnold I. 
Published: February 2007

AbstractA case of locally invasive malignant thymoma is presented. This 8‐month‐old child presented with respiratory distress and superior vena cava syndrome. Histology revealed malignant lymphocytic thymoma infiltrating the great vessels, pericardium, and regional lymph node. He was successfully treated with surgical removal, radiotherapy, and aggressive chemotherapy. We believe he is the youngest child with thymoma reported in medical literature.
Mercury‐induced necrosis of murine renal cell carcinoma
Authors: Herr Harry W. , Kleinert Edward L. , Whitmore Willet F. 
Published: February 2007

AbstractAdministration of the nephrotoxic agent, bichloride of mercury (HgCl2), to BALB/c mice bearing subcapsular renal tumor transplants induced early preferential necrosis of the tumor cells compared with mercury‐treated normal kidney tubular cells and untreated control tumors. The principle is established that a selective proximal tubular poison is also toxic for a tumor of the same cellular origin.
Results of combined chemosurgical therapy for pulmonary metastases
Authors: Blondet R. , Zlatoff P. , Frieh J. Ph , Brunat‐Mentigny M. , Pasini E. , Bobin J. Y. , Mayer M. 
Published: February 2007

AbstractThe authors study the results of the combined surgery and postoperative chemotherapy, for treatment of pulmonary metastases. At Léon‐Bérard Center, 50 patients have been operated on, since 1963. The sites and histologies of the primitive cancers are varied, corresponding to 12 epidermoid cancers, 12 adenocarcinomas, 10 osteogenic sarcomas, 1 Ewing's tumor, 3 malignant melanomas, 6 testicular tumors, and 4 others. The total survival rate is 30% in 4 years. The prognosis is influenced by different factors, which are studied. It depends on the histology of the primitive cancer and the type of the pulmonary excision. It is suggested that postoperative chemotherapy improves the results. It appears that the longer the free interval is between the treatment of the primitive cancer and the discovery of the pulmonary metastasis, the better the prognosis. The correlation between the time lapse of the free interval and the survey after pulmonary excision is studied. The conclusions of the authors are: The association of surgery and chemotherapy improves the results and enforces the indications for surgical excision of pulmonary metastases.
Pap smears: Access to hospital outpatients of nongynecological services
Authors: Kizilbash Mehdi , Mettlin Curtis 
Published: February 2007

AbstractAt a comprehensive cancer center, evaluation of the first year's experience with routine Pap smears offered to 6,851 nongynecological outpatients showed that after exempting those with a recent smear, medical contraindication or preference for their personal physician, 19.5% comprising the underscreened population, was given a smear on the current visit. This approach provided comprehensive access on a cost‐effective basis. Conceivably, primary care community hospitals could also offer routine smears to their underscreened outpatient population in a systematic manner to expand impact on public health.
Primary adenocarcinoma of the esophagus: A review of 12 cases
Authors: Reyes Cesar V. , Wang Taishine 
Published: February 2007

AbstractTo evaluate its true incidence and related clinical characteristics, the definition of primary adenocarcinoma of the esophagus is reemphasized. The tumor constitutes 2% of all esophageal malignancies. Its symptomatology, biologic behavior, and ultimate prognosis appear to be no different from the ordinary squamous cell carcinoma. Our analyses also support the implication of causal relationship between a columnar‐lined lower esophagus (Barrett's epithelium) and the neoplasm.
Long‐term remission of an advanced head and neck tumor following intra‐arterial infusion with cis‐dicholordiammine platinum
Authors: Horn Yoav , Adam Yehuda , Walach Natalio , Ilian Mahmoud 
Published: February 2007

AbstractA 65‐year‐old man with squamous cell carcinoma of the head and neck was initially treated with radiation therapy and systemic chemotherapy resulting in a complete remission. Recurring tumor, 2½ years later, caused advanced destruction of most left hemi‐face tissues. Intraarterial infusion with cis‐dichlorodiammine platinum (CDDP) to a total dose of 125 mg resulted in a complete remission of 15 months duration.The value of the use of the intra‐arterial route in treating advanced head and neck tumors with CDDP is discussed.
The primary and secondary prevention of cancer
Authors: Spratt John S. 
Published: February 2007

AbstractPrevention of cancer is now divided into primary and secondary prevention. Primary prevention is that set of interventions that keeps a cancerous process from ever developing and includes health counseling and education, environmental controls, and product safety as examples. Secondary prevention is that set of interventions leading to the discovery and control of cancerous or precancerous processes while localized, i.e., screening, early detection, and effective treatment. Risk is lifelong for all, though it may vary in intensity among different groups. Jointly, primary and secondary prevention must be synthesized into optimum life time strategies that are best understood and evaluated under certain basic concepts of the epidemiology of cancer and operations research. The purpose of this report is to provide a brief review of these concepts applied to primary and secondary prevention of human cancer. Improved understanding of these concepts is essential for planning, implementation, and evaluation of prevention programs.
Purification of antigens from urine of a sarcoma patient by affinity chromatography
Authors: Huth James F. , Gupta Rishab K. , Morton Donald L. 
Published: February 2007

AbstractPrevious publications from our laboratory have demonstrated the presence of antigens in the urine of cancer patients detectable by the complement fixation (CF) assay. The purpose of this study was to develop a methodology for purification of these tumor‐associated antigen(s) using xenogeneic antisera as a specific immunoabsorbent. Urine possessing high antigen titer by CF was collected from sarcoma patients. Xenoantiserum to the urinary antigens was prepared by injection of concentrated, dialyzed urine mixed with complete Freund's adjuvant into rabbits. Control xenoantisera were obtained by injection of pooled human normal urine in an identical manner. The antisarcoma urine xenoantisera were absorbed with human normal liver and insolubilized human normal serum to remove cross‐reacting antibodies to normal human components. The immunoglobulin fraction of the xenoantisera was isolated by ammonium sulfate precipitation and covalently linked to Sepharose 4B beads. Urine from a sarcoma patient was reacted with the immunobeads, and the affinity absorbed antigen(s) were eluted with 3.5 M potassium thiocyanate. The affinity purified urinary antigen had a CF titer of 1:128 against xenoantisera that had been quantitatively absorbed with human normal liver cells and the insolubilized normal human serum. Absorption of the xenoantiserum with cultured allogeneic sarcoma cells removed all activity against the affinity purified antigen(s). The results suggest that the cultured sarcoma cells expressed antigens immunologically similar to those present in the urine of sarcoma patients, and that these antigens can be isolated from urine of cancer patients and purified by affinity chromatography. The affinity purified antigens(s) was labeled with 125I by the vapor phase chloramine‐T method, and a radioimmunoassay was developed. By radioimmunoassay, antisarcoma urine xenoantiserum absorbed with human normal liver and insolubilized serum had a titer of 1:4000 against the affinity purified antigen. Xenoantisera to pooled normal human urine treated similarly showed no reactivity to the affinity purified antigen. Polyacrylamide gel electrophoresis of the radiolabeled antigen(s) showed a single peak in the 40,000‐ to 50,000‐ dalton range.
Exploratory thoracotomy on a patient with previous malignancy—“metastasis” or “new primary” or “unrelated lesion”
Authors: Vyas J. J. , Desai P. B. , Rao Nagaraj D. 
Published: February 2007

AbstractSurgical resection of a solitary pulmonary metastasis is an established procedure. A medical generation ago when such a shadow appeared on chest roentgenogram of a patient who had known cancer elsewhere in body, it was assumed to be “metastasis” from an extrathoracic site. With increasing advances in knowledge, the occurrence of second primary or new lesion is now no more curiosity in clinical practice. To one's surprise, the lesions that are assumed to be metastatic have often turned out to be “fresh” lesion or even unrelated benign, granulomatous, inflammatory, or parasitic lesion. This paper analyses 66 patients during a period of 20 years who underwent thoracotomy for such solitary pulmonary lesions, and emphasizes the role of diagnostic‐cum‐therapeutic‐thoracotomy in such a clinical situation where in prethoracotomy tissue diagnosis is not forthcoming.
Clonal growth of normal and malignant human breast epithelia
Authors: Lan Sam , Smith Helene S. , Stampfer Martha R. 
Published: February 2007

AbstractWe have developed an efficient method for the growth of colonies from single breast epithelial cells derived from nonmalignant [6], primary [7], and metastatic [1] surgical specimens. The immediate sources of the cells were primary and secondary mass cultures. An enriched culture medium and fibroblast feeder layers were used. A linear relationship between the number of cells cultured and the number of colonies obtained was found. Efficiency of colony formation was higher for those derived from nonmalignant specimens (mean 24%) than those derived from malignant specimens (mean 11%). Fibroblast feeder layers increased the efficiency of colony formation and also supported extended growth of colonies.
Synovial sarcoma of the abdominal wall: A case report and study of its fine structure
Authors: Al‐Dewachi H. S. , Sangal B. C. , Zakaria M. A. K. 
Published: February 2007

AbstractA case of synovial sarcoma in the abdominal wall of a 50‐year‐old Iraqi female is reported. The ultrastructure of the tumor has been studied. Eight other cases of synovial sarcoma in the abdominal wall which were reported in the English literature up to 1978 have been reviewed. Synovial sarcomas in the abdominal wall tend to occur with a much greater frequency in females in contrast to such tumors in the extremities or the neck which tend to occur with a much greater frequency in males. No ultrastructure studies of abdominal wall synovial sarcomas could be found in the English literature. Ultrastructure characteristics of this tumor were similar to those arising in the usual sites and in the neck. However, the present study has indicated that the light and dark cells reported by earlier workers are not solely limited to the epitheloid areas but are also present in the spindle cell zones.
Immunogenicity and cross‐protection among b16 melanoma variants with differing proclivities to metastasize
Authors: Harte Paul J. , Steele Glenn , Munroe Alelia E. , Rayner Anthony A. , Wang Bosco S. , Wilson Richard E. , Mannick John A. 
Published: February 2007

AbstractWe report here the lack of any relationship between immunogenicity and the potential to metastasize among four B16 melanoma variants. Groups of C57BL/6J mice were immunized with one of four B16 variant lines (maintained by serial IM passage) that were shown in separate experiments to produce the following incidences of pulmonary metastases four to six weeks after isograft excision: M1, 10%–15%; M2, 10%–20%; M3, 75%–80%; and M4, 75%–90%. After immunization, mice were challenged with one of the four variant lines in a crisscross fashion. Two challenge doses for each line were chosen on the basis of earlier experiments showing 100% and 50% challenge tumor take in nonimmunized animals. Despite earlier work published from this laboratory showing that splenocytes harvested from immunized mice could distinguish antigenic differences among the B16 variants, we could find no significant difference in immunogenicity or cross‐protection among the lines regardless of their metastatic potential. We conclude that no correlation exists between the antigenic differences shown by in vitro splenocyte‐mediated cytotoxicity assays among the B16 variants and in vivo immunogenicity or cross‐protection experiments. Furthermore, the relationship (if any) between immunogenicity and the ability to metastasize among these B16 variants is not straightforward.
Gastric leiomyosarcoma: Clinical and pathological review of fifty patients
Authors: Lindsay Philip C. , Ordonez Nelson , Raaf John H. 
Published: February 2007

AbstractFifty patients with gastric leiomyosarcoma seen at M.D. Anderson Hospital between 1957 and 1978 were reviewed. Symptoms included weakness, gastrointestinal bleeding, and epigastric pain. An upper abdominal mass or tenderness was the most frequent physical finding. Laparotomy was performed in all patients, with gastric resection in 86%, and resection for cure in 68%. Survival after distal subtotal gastric resection (mean: 62 months) was longer than after proximal subtotal (30 months) or wedge resection (46 months). The five‐year survival was 19% for all patients, and 32% for those operated on for cure. A favorable prognosis was predicted by mild atypia or few mitoses (grade 1). No differences in survival were demonstrated between patients with tumors of different cell types (epithelioid, spindle, or pleomorphic). No lymph node in any patient contained metastatic tumor, suggesting a lymph node dissection need not be performed. Commonly, tumor spread was to liver or lungs or by direct invasion of contiguous tissue or organs. Radiotherapy and chemotherapy are of limited value in treating unresectable disease. If possible, both the primary lesion and recurrent rumor should be widely resected.
Effect of alkali metal salts on sarcoma I in A/J mice
Authors: El‐Domeiri Ali A. , Messiha Fathy S. , Hsia Wen‐Cheng 
Published: February 2007

AbstractThe chloride salts of lithium (Li+) and cesium (Cs+) were evaluated for their ability to influence the growth of Sarcoma I implants in A/J mice. The administration of daily doses of either 1 or 3 mEq/kg CsCl to these mice reduced the incidence and size of tumor implants. This effect was not apparent in animals receiving a smaller dose (0.5 mEq/kg) of the same drug. At the time of sacrifice the serum level of Cs+ in this latter group was approximately half that recorded in animals receiving the higher doses of CsCl. No effect on tumor incidence or rate of growth was observed in animals receiving different doses of LiCl. Because of the similarities that existed between cesium and potassium, it was postulated that the effect of cesium was due to alterations in the intracellular composition of the tumor cells. Also, the possible role of cytotoxic agents in potentiating the inhibitory effect of cesium on tumors was discussed.
Perforation complicating carcinoma of colon
Authors: Micbowitz M. , Avnieli D. , Lazarovici I. , Solowiejczyk M. 
Published: February 2007

AbstractEight hundred thirty‐six patients with carcinoma of colon and rectum were treated surgically in the Ichilov Medical Center from 1968 to 1975. Forty‐five patients (5.38%) suffering from perforative carcinoma were followed up. It was found that the treatment of choice for perforative carcinoma of the descending colon is primary resection without primary anastomosis. In ascending colon perforation the treatment of choice is primary resection with primary anastomosis. Thus aggressive surgical procedures afford the patient the best chance for smoother postoperative course and recovery. In patients surviving the operation, the survival time is not influenced by the type of perforation but by the stage of tumor invasion.
Hypoglycemia and hodgkin's disease with hyperinsulinemia
Authors: Smith Noel L. , Janelli Donald E. , Madariaga Juan , Mishriki Yousri 
Published: February 2007

AbstractA case report is presented here in which Hodgkin's disease with persistent hypoglycemia and hyperinsulinemia was present requiring constant 10% glucose infusions to prevent symptoms. Subtotal pancreatectomy with excision of adjacent Hodgkin's disease has relieved hypoglycemia and hyperinsulinemia.
The application of tissue adhesives in small bowel anastomoses
Authors: Petrelli Nicholas J. , Cohen Howard , Derisi Dwicht , Ambrus Julian L. , Williams Phyllis 
Published: February 2007

AbstractOne layer everted end‐to‐end anastomosis was performed on the small bowel of mongrel dogs. Cultures of Serratia marcescens were injected into the lumen. Twenty‐four hours later the animals were reexplored, and peritoneal cultures were observed. In animals where Fibrin Seal (consisting of fibrinogen, cold insoluble globulin, factor XIII, platelet growth factor, antiplasmin, thrombin, and calcium chloride) was applied to the suture line, negative cultures were found except for two experiments in which dehiscence or contamination from the Serratia injection site occurred.
Further evaluation by ultrasound of mammographically determined breast dysplasia
Authors: Frazier Thomas G. , Cole‐Beuglet Catherine , Kurtz Alfred B. , Goldberg Barry B. , Ryan Sally M. 
Published: February 2007

AbstractEvaluation of 135 consecutive patients was made for breast masses by the same surgeon and the patients were subsequently referred for ultrasound mammography of the breast after xeromammography revealed a “dysplastic” (DY) pattern only, with no evidence of malignancy. Three patients had carcinoma of the breast detected by ultrasound mammography that had been missed by xeromammography. Two of the three cancers were similarly diagnosed by fine‐needle aspiration cytology. All patients with a normal ultrasound examination have now been followed for a minimum of 15 months without evidence of developing breast cancer. This study confirms the importance of using additional diagnostic modalities for evaluating patients with dysplastic breasts and strongly suggests the value of ultrasound mammography in this group of patients.