bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis, crystal structure and in-silico evaluation of arylsulfonamide Schiff bases for potential activity against colon cancer
Authors: Kolade Sherif O. , Aina Oluwafemi S. , Gordon Allen T. , Hosten Eric C. , Olasupo Idris A. , Ogunlaja Adeniyi S. , Asekun Olayinka T. , Familoni Oluwole B. 
Published: March 2024

This report presents a comprehensive investigation into the synthesis and characterization of Schiff base compounds derived from benzenesulfonamide. The synthesis process, involved the reaction between N-cycloamino-2-sulfanilamide and various substituted o-salicylaldehydes, resulted in a set of compounds that were subjected to rigorous characterization using advanced spectral techniques, including 1H NMR, 13C NMR and FT–IR spectroscopy, and single-crystal X-ray diffraction. Furthermore, an in-depth assessment of the synthesized compounds was conducted through Absorption, Distribution, Metabolism, Excretion and Toxicity (ADMET) analysis, in conjunction with docking studies, to elucidate their pharmacokinetic profiles and potential. Impressively, the ADMET analysis showcased encouraging drug-likeness properties of the newly synthesized Schiff bases. These computational findings were substantiated by molecular properties derived from density functional theory (DFT) calculations using the B3LYP/6-31G* method within the Jaguar Module of Schrödinger 2023-2 from Maestro (Schrodinger LLC, New York, USA). The exploration of frontier molecular orbitals (HOMO and LUMO) enabled the computation of global reactivity descriptors (GRDs), encompassing charge separation (E
gap) and global softness (S). Notably, within this analysis, one Schiff base, namely, 4-bromo-2-{N-[2-(pyrrolidine-1-sulfonyl)phenyl]carboximidoyl}phenol, 20, emerged with the smallest charge separation (ΔE
gap = 3.5780 eV), signifying heightened potential for biological properties. Conversely, 4-bromo-2-{N-[2-(piperidine-1-sulfonyl)phenyl]carboximidoyl}phenol, 17, exhibited the largest charge separation (ΔE
gap = 4.9242 eV), implying a relatively lower propensity for biological activity. Moreover, the synthesized Schiff bases displayed remarkeable inhibition of tankyrase poly(ADP-ribose) polymerase enzymes, integral in colon cancer, surpassing the efficacy of a standard drug used for the same purpose. Additionally, their bioavailability scores aligned closely with established medications such as trifluridine and 5-fluorouracil. The exploration of molecular electrostatic potential through colour mapping delved into the electronic behaviour and reactivity tendencies intrinsic to this diverse range of molecules.
A new winding homogenization method based on thermal resistance concept
Authors: Hashemi Ali , Yazdanpanah Qaraei Parsa , Shabanian-Poodeh Mostafa 
Published: March 2024

Purpose
The aim of this paper is to provide a simple yet accurate and efficient geometric method for thermal homogenization of impregnated and non-impregnated coil winding technologies based on the concept of thermal resistance.

Design/methodology/approach
For regular windings, the periodic microscopic cell in the winding space is identified. Also, for irregular windings, the average microscopic cell of the winding is determined. An approximation is used to calculate the thermal resistance of the winding cell. Based on this approximation, the winding insulation is considered as a circular ring around the wire. Mathematical equations are obtained to calculate the equivalent thermal resistance of the cell. The equivalent thermal conductivity of the winding is calculated using equivalent thermal resistance of the cell. Winding thermal homogenization is completed by determining the equivalent thermal properties of the cell.

Findings
The thermal pattern of different windings is simulated and compared with the results of different homogenization methods. The results show that the proposed method is applicable for a wide range of windings in terms of winding scheme, packing factor and winding insulation. Also, the results show that the proposed method is more accurate than other winding homogenization methods in calculating the equivalent thermal conductivity of the winding.

Research limitations/implications
In this paper, the change of electrical resistance of the winding with temperature and thermal contact between the sub-components are ignored. Also, liquid insulators, such as oils, and rectangular wires were not investigated. Research in these topics is considered as future work.

Originality/value
Unlike other homogenization methods, the proposed method can be applied to non-impregnated and irregular windings. Also, compared to other homogenization methods, the proposed method has a simpler formulation that makes it easier to program and implement. All of these indicate the efficiency of the proposed method in the thermal analysis of the winding.
Extractivism and the engendering of disasters: disaster risk creation in the era of the Anthropocene
Authors: Bradshaw Sarah 
Published: March 2024

PurposeThis paper argues that extractivist logic creates the environmental conditions that produce “natural” hazards and also the human conditions that produce vulnerability, which combined create disasters. Disaster Risk Creation is then built into the current global socio-economic system, as an integral component not accidental by-product.Design/methodology/approachAs part of the movement to liberate disasters as discipline, practice and field of enquiry, this paper does not talk disasters per se, but rather its focus is on “extractivism” as a fundamental explanator for the anthropogenic disaster landscape that now confronts us.FindingsApplying a gender lens to extractivism as it relates to disaster, further highlights that Disaster Risk Management rather than alleviating, creates the problems it seeks to solve, suggesting the need to liberate gender from Disaster Risk Management, and the need to liberate us all from the notion of managing disasters. Since to ‘manage’ disaster risk is to accept uncritically the structures and systems that create that risk, then if we truly want to address disasters, our focus needs to be on the extractive practices, not the disastrous outcomes.Originality/valueThe fundamental argument is that through privileging the notion of “disaster” we create it, bring it into existence, as something that exists in and of itself, apart from wider socio-economic structures and systems of extraction and exploitation, rather than recognising it for what it is, an outcome/end product of those wider structures and systems. Our focus on disaster is then misplaced, and perhaps what disaster studies needs to be liberated from, is itself.
Integrating rational and irrational factors towards explicating investment satisfaction and reinvestment intentions: a study in the context of direct residential real estate
Authors: R. Sharmila Devi , Perumandla Swamy , Bhattacharyya Som Sekhar 
Published: March 2024

Purpose
The purpose of this study is to understand the investment decision-making of real estate investors in housing, highlighting the interplay between rational and irrational factors. In this study, investment satisfaction was a mediator, while reinvestment intention was the dependent variable.

Design/methodology/approach
A quantitative, cross-sectional and descriptive research design was used, gathering data from a sample of 550 residential real estate investors using a multi-stage stratified sampling technique. The partial least squares structural equation modelling disjoint two-stage approach was used for data analysis. This methodological approach allowed for an in-depth examination of the relationship between rational factors such as location, profitability, financial viability, environmental considerations and legal aspects alongside irrational factors including various biases like overconfidence, availability, anchoring, representative and information cascade.

Findings
This study strongly supports the adaptive market hypothesis, showing that residential real estate investor behaviour is dynamic, combining rational and irrational elements influenced by evolutionary psychology. This challenges traditional views of investment decision-making. It also establishes that behavioural biases, key to adapting to market changes, are crucial in shaping residential property market efficiency. Essentially, the study uncovers an evolving real estate investment landscape driven by evolutionary behavioural patterns.

Research limitations/implications
This research redefines rationality in behavioural finance by illustrating psychological biases as adaptive tools within the residential property market, urging a holistic integration of these insights into real estate investment theories.

Practical implications
The study reshapes property valuation models by blending economic and psychological perspectives, enhancing investor understanding and market efficiency. These interdisciplinary insights offer a blueprint for improved regulatory policies, investor education and targeted real estate marketing, fundamentally transforming the sector’s dynamics.

Originality/value
Unlike previous studies, the research uniquely integrates human cognitive behaviour theories from psychology and business studies, specifically in the context of residential property investment. This interdisciplinary approach offers a more nuanced understanding of investor behaviour.
Impact of inventory management on SME performance: a systematic review
Authors: Panigrahi Rashmi Ranjan , Shrivastava Avinash K. , Nudurupati Sai Sudhakar 
Published: March 2024

PurposeEffective inventory management is crucial for SMEs due to limited resources and higher risks like cash flow, storage space, and stockouts. Hence, the aim is to explore how technology and know-how can be integrated with inventory practices and impact operational performance.Design/methodology/approachThe basis of the analysis was collecting papers from a wide range of databases, which included Scopus, Web of Science, and Google Scholar. In the first phase of the process, a search string with as many as nine related keywords was used to obtain 175 papers. It further filtered them based on their titles and abstracts to retain 95 papers that were included for thorough analysis.FindingsThe study introduced innovative methods of measuring inventory practices by exploring the impact of know-how. It is the first of its kind to identify and demonstrate how technical, technological, and behavioral know-how can influence inventory management practices and ultimately impact the performance of emerging SMEs. This study stands out for its comprehensive approach, which covers traditional and modern inventory management technologies in a single study.Research limitations/implicationsThe study provides valuable insights into the interplay between technical, technological, and behavioral know-how in inventory management practices and their effects on the performance of emerging SMEs in Industry 5.0 in the light of RBV theory.Originality/valueThe RBV theory and the Industry 5.0 paradigm are used in this study to explore how developing SMEs' inventory management practices influence their performance. This study investigates the effects of traditional and modern inventory management systems on business performance. Incorporating RBV theory with the Industry 5.0 framework investigates firm-specific resources and technological advances in the current industrial revolution. This unique technique advances the literature on inventory management and has industry implications.
The effects of knowledge base characteristics on patent pledge financing: the moderating effects of technological munificence and dynamism
Authors: Zhang Zhiqun , Yang Xia , Yang Xue , Gu Xin 
Published: March 2024

Purpose
This study aims to examine how the knowledge breadth and depth of a patent affect its likelihood of being pledged. It also seeks to explore whether these relationships change diversely in different technological environments.

Design/methodology/approach
A complementary log-log model with random effects was conducted to test the hypotheses using a unique data set consisting of 348,927 invention patents granted by the China National Intellectual Property Administration from 1985 to 2015 belonging to 74,996 firms.

Findings
The findings reveal that both knowledge breadth and depth of a patent positively affect its likelihood of being pledged. Furthermore, the knowledge breadth and depth entail different degrees of superiority in different technological environments.

Research limitations/implications
This study focuses on the effect of an individual patent’s knowledge base on its likelihood of being selected as collateral. It does not consider the influence of the overall knowledge characteristics of the selected patent portfolio.

Practical implications
Managers need to pay attention to patents’ knowledge characteristics and the changes in technological environments to select the most suitable patents as collateral and thus improve the success rate of pledge financing.

Originality/value
This study explores the impact of multidimensional characteristics of knowledge base on patent pledge financing within a systematic theoretical framework and incorporates technological environments into this framework.
An integrated QFD framework for smart city strategy development
Authors: Kamvysi Konstantina , Tsironis Loukas K. , Gotzamani Katerina 
Published: March 2024

PurposeIn this study, the deployment of an integrated Quality Function Deployment (QFD) decision framework is presented to help cities design targeted strategies to become “smart”. Arguably smart cities leverage advanced technologies to enhance their smartness to improve everyday urban life. To this end, a QFD – Analytic Hierarchy Process – Analytic Network Process (QFD-AHP-ANP) framework is proposed to deliver guidance for selecting the appropriate mix of smart technologies based on the specific smart needs of each city.Design/methodology/approachThe AHP and ANP methods are incorporated into QFD to enhance its methodological robustness in formulating the decision problem. AHP accurately captures and translates the “Voice of the Experts” into prioritized “Smart City” dimensions, while establishing inter-relationships between these dimensions and “Smart City Technologies”. Meanwhile, ANP explores tradeoffs among the technologies, enabling well-informed decisions. The framework’s effectiveness is evaluated through an illustrative application in the city of Thessaloniki.FindingsApplying the framework to this real-world context confirms its practicality and utility, demonstrating its ability to particularize local, social, political, environmental and economic trends through the resulting mix of technologies in smart urban development strategies.Originality/valueThe importance of this study lies in several aspects. Firstly, it introduces a novel QFD decision framework tailored for smart city strategic planning. Secondly, it contributes to the operationalization of the smart city concept by providing guidance for cities to effectively adopt smart technologies. Finally, this study represents a new field of application for QFD, expanding its scope beyond its traditional domains.
Emigration and radical right populism
Authors: Dancygier Rafaela , Dehdari Sirus H. , Laitin David D. , Marbach Moritz , Vernby Kåre 
Published: March 2024

AbstractAn extensive literature links the rise of populist radical right (PRR) parties to immigration. We argue that another demographic trend is also significant: emigration. The departure of citizens due to internal and international emigration is a major phenomenon affecting elections via two complementary mechanisms. Emigration alters the composition of electorates, but also changes the preferences of the left behind. Empirically, we establish a positive correlation between PRR vote shares and net‐migration loss at the subnational level across Europe. A more fine‐grained panel analysis of precincts in Sweden demonstrates that the departure of citizens raises PRR vote shares in places of emigration and that the Social Democrats are the principal losers from emigration. Elite interviews and newspaper analyses explore how emigration produces material and psychological grievances on which populists capitalize and that established parties do not effectively address. Emigration and the frustrations it generates emerge as important sources of populist success.
Organizational dehumanization fuelling opportunistic behaviour: A social exchange perspective
Authors: Bibi Afshan , Al Hassan Sidrah , Zahur Hafsah 
Published: March 2024

AbstractOrganizations generally treat their employees as tools for attaining maximum efficiency to achieve their production targets. In this regard, it is important to note that the global post‐pandemic era spiced up with technological advent has further catalysed the existing mechanistic approach towards the workforce. Moreover, the investigation of organizational dehumanization in the Asian region has its unique significance. This pervasive phenomenon needs scholarly attention to realize its deleterious outcomes. Therefore, this study aimed to investigate the relationship between organizational dehumanization and opportunistic behaviour. Moreover, the underlying mechanism of calculative commitment was proposed along with the negative reciprocity norms moderating the indirect effect of organization dehumanization to opportunistic behaviour through calculative commitment. The proposed model was grounded on the assumptions of social exchange theory. The survey method was utilized to collect from the service sector organizations operating in both private and public sector organizations in the twin cities of Rawalpindi and Islamabad, Pakistan. The data were collected in three‐time lags (2 weeks), with peer‐reported opportunistic behaviour. The CFA was done, followed by the utilization of model 4 and model 7 to test hypotheses. The results established a positive relationship between organizational dehumanization and opportunistic behaviour. Moreover, the mediation of calculative commitment was proven empirically with the high levels of negative reciprocity norms strengthening the indirect effect of organizational dehumanization to opportunistic behaviour through calculative commitment.
Exploring sexual function in adrenal insufficiency: findings from the Dual RElease hydrocortisone versus conventionAl glucocorticoid replaceMent therapy in hypocortisolism (DREAM) trial
Authors: Hasenmajer Valeria , De Alcubierre Dario , Ferrari Davide , Minnetti Marianna , Bonaventura Ilaria , Pofi Riccardo , Simeoli Chiara , Tomaselli Alessandra , Sciarra Francesca , Bottillo Grazia , Angelini Francesco , Cozzolino Alessia , Venneri Mary Anna , Jannini Emmanuele A. , Gianfrilli Daniele , Pivonello Rosario , Isidori Andrea M. 
Published: March 2024

AbstractBackgroundData on sexual function in patients with adrenal insufficiency are scarce and largely controversial.ObjectivesTo investigate sexual dysfunction in patients with primary and secondary adrenal insufficiency and the effects of switching to once‐daily dual‐release hydrocortisone on sexual function in outcome assessors blinded, randomized, multicenter, active comparator clinical trial.Materials and methodsEighty‐nine adrenal insufficiency patients on conventional, multiple daily doses of glucocorticoid replacement, enrolled in the Dual RElease hydrocortisone versus conventionAl glucocorticoid replaceMent in hypocortisolism (DREAM) trial, were randomly assigned to continue their therapy or to switch to an equivalent dose of dual‐release hydrocortisone. Sixty‐three patients (34 women) consented to sex steroid measurements and questionnaires completion for quality of life (Addison's disease‐specific quality‐of‐life questionnaire) and sexual function evaluation (female sexual function index for women, International Index of Erectile Function‐Erectile Function for men) at baseline and 24 weeks after randomization.ResultsAt baseline, sexual dysfunction was observed in 41% of women and 59% of men with adrenal insufficiency. In both sexes, no associations were found between sexual function and hormone levels, whereas Addison's disease‐specific quality‐of‐life questionnaire total and fatigue domain scores positively correlated with total female sexual function index and International Index of Erectile Function‐Erectile Function scores. At 24 weeks, there was no significant difference either in sexual function or sex steroid levels between study groups. In the dual‐release hydrocortisone group, the variation in the female sexual function index desire domain score was positively associated with the change in Addison's disease‐specific quality‐of‐life questionnaire's symptom domain score (ρ = 0.478, p = 0.045).DiscussionSexual dysfunction is common in adrenal insufficiency patients and is likely explained by multiple factors. dual‐release hydrocortisone treatment is not directly associated with sexual function improvement, but an indirect effect mediated by quality‐of‐life amelioration cannot be excluded.
Method for evaluating milk production in mouse mammary gland
Authors: Sakai Hibiki , Kamikawa Akihiro 
Published: March 2024

AbstractLactation is a characteristic physiological function of mammals and is important for nourishing infants and the dairy industry; however, the molecular mechanisms underlying the function remain to be elucidated. A technique to directly evaluate the quantity and quality of milk in mice is necessary for the study of the lactation mechanism in vivo. By measuring the changes in milk amount after different durations of milk accumulation (0–24 h) using a ductal cannulation technique and oxytocin supplementation, we estimated the milk production rate at a single mammary gland level. In addition, collected milk was available to assess milk quality, including creamatocrit, osmolarity, and concentrations of ions, lactose, and total protein. Moreover, as a proof of principle, the effects of intraductal administration of a hypertonic solution to the abdominal mammary gland were examined. This stimulation increased milk amount, possibly by osmosis, compared with the contralateral control gland. These results demonstrated that this method is useful for examining the lactation ability and mechanisms in vivo. Studies using this method will contribute to the further understanding of lactation mechanisms in mammals.
Assessing the value orientation preferences and the importance given to principled moral reasoning of Generation Zs: A cross‐generational comparison
Authors: Weber James 
Published: March 2024

AbstractWithin the past few years, a new generation has joined the ranks of business managers or is preparing to become business managers: Generation Z (Gen Z), described as individuals born between 1995 and 2010. This paper has two aims: (1) to assess the Gen Z cohort framed by their value orientation preferences (VOP) and the importance given to principled moral reasoning (PMR) using values and cognitive moral reasoning theories and (2) to compare this information about the Gen Z cohort to prior generations. Using the Rokeach Value Survey and the Moral Reasoning Inventory, we uncovered support for our expectations that Gen Zs would have a balanced set of VOP—that is, similar preferences for a personal and a social value orientation and similar preferences for a competence and moral value orientation. Further, Gen Z preferences are unlike prior generations. The importance given to principled moral reasoning to resolve ethical dilemmas is lower than Baby Boomers and Gen Xers but surprisingly higher than Millennials as found in prior studies. Implications of these discoveries and suggestions for future research are presented.