bluuebunny/crossref_metadata_2025_split huggingface dataset:
Communication Within Firms: Evidence from CEO Turnovers
Authors: Impink Stephen Michael , Prat Andrea , Sadun Raffaella 
Published: April 2024

This paper uses novel, firm-level communication measures derived from communications metadata several months before and after a CEO transition for 102 firms to study whether and how this organizational event is reflected in employees’ communication flows. We find that CEO turnover is associated with an initial decrease in intrafirm communication (−20% relative to the pre-CEO transition period), followed by a significant increase approximately five months after the CEO turnover (+20% relative to the pre-CEO transition period). The increase in communication is driven primarily by interdepartmental (i.e., communication involving employees of different functional departments) and vertical (i.e., communication among managers and employees) communication flows. This study suggests that communications metadata are a useful tool to examine how organizational change and related uncertainty impact information flows within firms. This paper was accepted by Alfonso Gambardella, business strategy. Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2022.02719 .
Commitment on Volunteer Crowdsourcing Platforms: Implications for Growth and Engagement
Authors: Lo Irene , Manshadi Vahideh , Rodilitz Scott , Shameli Ali 
Published: April 2024

Problem definition: Volunteer crowdsourcing platforms match volunteers with tasks that are often recurring. To ensure completion of such tasks, platforms frequently use a lever known as “adoption,” which amounts to a commitment by the volunteer to repeatedly perform the task. Despite reducing match uncertainty, high levels of adoption can decrease the probability of forming new matches, which in turn can suppress growth. We study how platforms should manage this trade-off. Our research is motivated by a collaboration with Food Rescue U.S. (FRUS), a volunteer-based food recovery organization active in more than 30 locations. For platforms such as FRUS, effectively using nonmonetary levers, such as adoption, is critical. Methodology/results: Motivated by the volunteer management literature and our analysis of FRUS data, we develop a model for two-sided markets that repeatedly match volunteers with tasks. We study the platform’s optimal policy for setting the adoption level to maximize the total discounted number of matches. When market participants are homogeneous, we fully characterize the optimal myopic policy and show that it takes a simple extreme form: depending on volunteer characteristics and market thickness, either allow for full adoption or disallow adoption. In the long run, we show that such a policy is either optimal or achieves a constant-factor approximation. We further extend our analysis to settings with heterogeneity and find that the structure of the optimal myopic policy remains the same if volunteers are heterogeneous. However, if tasks are heterogeneous, it can be optimal to only allow adoption for the harder-to-match tasks. Managerial implications: Our work sheds light on how two-sided platforms need to carefully control the double-edged impacts that commitment levers have on growth and engagement. Setting a misguided adoption level may result in marketplace decay. At the same time, a one-size-fits-all solution may not be effective, as the optimal design crucially depends on the characteristics of the volunteer population. Supplemental Material: The online appendices are available at https://doi.org/10.1287/msom.2020.0426 .
Eliminating sticking effects among fine strokes in micropatterning complex Chinese characters
Authors: Kong Xiangbin , Wei Jingsong , Huang Zhihong , Gao Tianyu 
Published: April 2024

In this work, complex Chinese micropatterns are experimentally inscribed in AgInSbTe thin films through laser writing technique. The overlapping inscription strategy is introduced to reduce the size of complex Chinese micropatterns, and the erosion algorithm is used to eliminate sticking effects among fine strokes in complex Chinese micropatterns. The results show that the size of complex Chinese micropatterns can be reduced to around 15.41µm×15.41µm. The width of the finest stroke is only 0.45 µm. This method can achieve a fidelity of 95%. This work helps with the long-term preservation of massive Chinese character archives.
Transcriptional signatures in human macrophage-like cells infected by Leishmania infantum, Leishmania major and Leishmania tropica
Authors: Diotallevi Aurora , Bruno Federica , Castelli Germano , Persico Giuseppe , Buffi Gloria , Ceccarelli Marcello , Ligi Daniela , Mannello Ferdinando , Vitale Fabrizio , Magnani Mauro , Galluzzi Luca 
Published: April 2024

Background
In the Mediterranean basin, three Leishmania species have been identified: L. infantum, L. major and L. tropica, causing zoonotic visceral leishmaniasis (VL), zoonotic cutaneous leishmaniasis (CL) and anthroponotic CL, respectively. Despite animal models and genomic/transcriptomic studies provided important insights, the pathogenic determinants modulating the development of VL and CL are still poorly understood. This work aimed to identify host transcriptional signatures shared by cells infected with L. infantum, L. major, and L. tropica, as well as specific transcriptional signatures elicited by parasites causing VL (i.e., L. infantum) and parasites involved in CL (i.e., L. major, L. tropica).

Methodology/Principal findings
U937 cells differentiated into macrophage-like cells were infected with L. infantum, L. major and L. tropica for 24h and 48h, and total RNA was extracted. RNA sequencing, performed on an Illumina NovaSeq 6000 platform, was used to evaluate the transcriptional signatures of infected cells with respect to non-infected cells at both time points. The EdgeR package was used to identify differentially expressed genes (fold change > 2 and FDR-adjusted p-values < 0.05). Then, functional enrichment analysis was employed to identify the enriched ontology terms in which these genes are involved. At 24h post-infection, a common signature of 463 dysregulated genes shared among all infection conditions was recognized, while at 48h post-infection the common signature was reduced to 120 genes. Aside from a common transcriptional response, we evidenced different upregulated functional pathways characterizing L. infantum-infected cells, such as VEGFA-VEGFR2 and NFE2L2-related pathways, indicating vascular remodeling and reduction of oxidative stress as potentially important factors for visceralization.

Conclusions
The identification of pathways elicited by parasites causing VL or CL could lead to new therapeutic strategies for leishmaniasis, combining the canonical anti-leishmania compounds with host-directed therapy.
Prevalence of cardiometabolic risk factors according to urbanization level, gender and age, in apparently healthy adults living in Gabon, Central Africa
Authors: Mengome Mérédith Flore Ada , Kono Héléna Noéline , Bivigou Elsa Ayo , M’bondoukwe Noé Patrick , Ngomo Jacques-Mari Ndong , Ditombi Bridy Moutombi , Ngondza Bedrich Pongui , Bisseye Cyrille , Mawili-Mboumba Denise Patricia , Bouyou Akotet Marielle Karine 
Published: April 2024

Background
The prevalence of cardiometabolic risk factors (CMRFs) is increasing in sub-Saharan Africa and represents a serious public health issue. Accurate data are required to implement adapted prevention programs and healthcare strategies. Thus, the aim of this study was to estimate the prevalence rates of CMRFs according to the level of urbanization, age and gender in Gabon.

Methods
A cross-sectional study was conducted in northern (Bitam), western coast (Libreville, Melen) and southeast (Koulamoutou) areas of Gabon using the World Health Organization’s (WHO) stepwise approach for the surveillance of chronic disease risk factors. Participants over 18 years of age, without known underlying disease, living in rural and urban areas of Gabon were included. Sociodemographic, biological, and behavioral data were collected. Univariate and multivariate analysis were used to identify the CMRFs.

Results
Of the 978 participants, 499 lived in urban and 479 in rural areas. Their median age was 38[28–50] years. Tobacco (26.1% vs 6.2%; p < 0.01) and excessive alcohol consumption (19.4% vs 9.6%; p < 0.01) predominated in rural than in urban areas, respectively. Urban dwellers had more often insufficient physical activity than rural people (29.5% vs 16.3%; p < 0.01). In total, 79.9% of participants aged under 54 years had a high blood pressure;10.6% of the younger participants had pre-hypertension. Metabolic syndrome was more frequent in women (21.7%) than in men (10.0%) (p < 0.01); 6.4% of men and 2.5% of women had a high Framingham score (p = 0.03). Finally, 54.0% of the participants had three or four CMRFs. The multivariate analysis showed that men were more likely to be smokers and to be at risk of pre-hypertension or high blood pressure (p < 0.01). Women were more likely to be obese or to have a metabolic syndrome (p < 0.01). Living in urban areas was also a risk factor for hypertension, diabetes, metabolic syndrome and high LDL cholesterol level.

Conclusion
The prevalence of CMRFs was high in the study population. Disparities were observed according to urban and rural areas, gender and age. National prevention and healthcare strategies for cardiometabolic diseases in Gabon should consider these observed differences.
Impact of improved dead time correction on the quantification accuracy of a dedicated BrainPET scanner
Authors: Issa Ahlam Said Mohamad , Scheins Jürgen , Tellmann Lutz , Brambilla Cláudia Régio , Lohmann Philipp , Rota-Kops Elena , Herzog Hans , Neuner Irene , Shah N. Jon , Lerche Christoph 
Published: April 2024

Objective
Quantitative values derived from PET brain images are of high interest for neuroscientific applications. Insufficient DT correction (DTC) can lead to a systematic bias of the output parameters obtained by a detailed analysis of the time activity curves (TACs). The DTC method currently used for the Siemens 3T MR BrainPET insert is global, i.e., differences in DT losses between detector blocks are not considered, leading to inaccurate DTC and, consequently, to inaccurate measurements masked by a bias. However, following careful evaluation with phantom measurements, a new block-pairwise DTC method has demonstrated a higher degree of accuracy compared to the global DTC method.

Approach
Differences between the global and the block-pairwise DTC method were studied in this work by applying several radioactive tracers. We evaluated the impact on [11C]ABP688, O-(2-[18F]fluoroethyl)-L-tyrosine (FET), and [15O]H2O TACs.

Results
For [11C]ABP688, a relevant bias of between -0.0034 and -0.0053 ml/ (cm3 • min) was found in all studied brain regions for the volume of distribution (VT) when using the current global DTC method. For [18F]FET-PET, differences of up to 10% were observed in the tumor-to-brain ratio (TBRmax), these differences depend on the radial distance of the maximum from the PET isocenter. For [15O]H2O, differences between +4% and -7% were observed in the GM region. Average biases of -4.58%, -3.2%, and -1.2% for the regional cerebral blood flow (CBF (K1)), the rate constant k2, and the volume of distribution VT were observed, respectively. Conversely, in the white matter region, average biases of -4.9%, -7.0%, and 3.8% were observed for CBF (K1), k2, and VT, respectively.

Conclusion
The bias introduced by the global DTC method leads to an overestimation in the studied quantitative parameters for all applications compared to the block-pairwise method.

Significance
The observed differences between the two DTC methods are particularly relevant for research applications in neuroscientific studies as they affect the accuracy of quantitative Brain PET images.
COCCOS study: Developing a transition program for adolescents with chronic conditions using Experience-Based Co-Design. A study protocol
Authors: Janssens Natwarin , Van Wilder Lisa , Van Hecke Ann , Van Hoorenbeeck Kim , Vanden Wyngaert Karsten , De Smedt Delphine , Goossens Eva 
Published: April 2024

Background
During adolescence, adolescents and young adults (AYAs) are expected to transfer their care from the pediatric environment towards an adult-focused setting. To prevent an abrupt transfer of care, it is recommended to provide AYAs with chronic conditions an adequate transition program. The aim of this paper is to describe the study protocol for the development of a transition program for AYAs with common chronic conditions (COCCOS study), using the Experience-Based Co-Design (EBCD) methodology.

Methods and analysis
A qualitative, participatory study is conducted in Flanders (Belgium). Study participants are AYAs (n≥15, 14–25 years old, diagnosed with type 1 diabetes, asthma, or obesity), their families, and healthcare providers (n≥15). The study is composed of eight EBCD stages: clinical site observations, in-depth interviews, trigger film, healthcare providers’ feedback event, AYAs’ feedback event, joint event, co-design workshops, and a celebration event. Photovoice will take place as a starting point of EBCD. Data will be analyzed using thematic analysis.

Results
Data collection has started in January 2023 and is expected to be completed in May 2024. As of August 2023, over 15 clinical site observations have been conducted. A total of 18 AYAs, two parents, six healthcare providers have been enrolled and a total of 20 interviews have been conducted.

Conclusion
Advancing transitional care is essential for tackling negative health outcomes. Applying the innovative participatory EBCD methodology will reveal key elements of transitional care for AYAs with common chronic conditions in the development of a person-centered transition program.

Practice implications
Study findings will apply key elements of transitional care of AYAs with chronic conditions in the development of an adequate transition program.
Effects of fecal microbiota transfer on blood pressure in animal models: A systematic review and meta-analysis
Authors: Lin Lingyu , Xu Shurong , Cai Meiling , Li Sailan , Chen Yaqin , Chen Liangwan , Lin Yanjuan 
Published: April 2024

Background
Numerous recent studies have found a strong correlation between intestinal flora and the occurrence of hypertension. However, it remains unclear whether fecal microbiota transfer might affect the blood pressure of the host. This study aimed to quantify both associations.

Methods
An electronic search was conducted in PubMed, EMBASE, Cochrane Library, Web of Science, China National Knowledge Infrastructure (CNKI), WanFang database, Weipu, Embase, and SinoMed to retrieve relevant studies. The final search was completed on August 22, 2022. Two authors independently applied the inclusion criteria, extracted data, and assessed the risk of bias assessment. All data were analyzed using RevMan 5.4.

Results
A total of 5 articles were selected for final inclusion. All studies were assessed as having a high risk of bias according to the SYRCLE risk of bias tool. The meta-analysis results showed that transplantation of fecal bacteria from the hypertensive model can significantly improve the host’s systolic pressure (MD = 18.37, 95%CI: 9.74~26.99, P<0.001), and diastolic pressure (MD = 17.65, 95%CI: 12.37~22.93, P<0.001). Subgroup analyses revealed that the increase in systolic pressure in the hypertension model subgroup (MD = 29.56, 95%CI = 23.55–35.58, P<0.001) was more pronounced than that in the normotensive model subgroup (MD = 12.48, 95%CI = 3.51–21.45, P<0.001).

Conclusion
This meta-analysis suggests a relationship between gut microbiota dysbiosis and increased blood pressure, where transplantation of fecal bacteria from the hypertensive model can cause a significant increase in systolic pressure and diastolic pressure in animal models.
Catheter ablation of atrial arrhythmias in cardiac amyloidosis: Impact on heart failure and mortality
Authors: Maury Philippe , Sanchis Kevin , Djouadi Kamila , Cariou Eve , Delasnerie Hubert , Boveda Serge , Fournier Pauline , Itier Romain , Mondoly Pierre , Voglimacci-Stephanopoli Quentin , Beneyto Maxime , Dhanjal Tarvinder S. , Rollin Anne , Damy Thibaud , Lairez Olivier , Lellouche Nicolas 
Published: April 2024

Background
Atrial arrhythmias (AA) commonly affect patients with cardiac amyloidosis (CA) and are a contributing risk factor for the development of heart failure (HF). This study sought to investigate the long-term efficacy and impact of catheter ablation on HF progression in patients with CA and AA.

Methods
Thirty-one patients with CA and AA undergoing catheter ablation were retrospectively included (transthyretin—ATTR CA 61% and light chain—AL CA 39%). AA subtypes included atrial fibrillation (AFib) in 22 (paroxysmal in 10 and persistent in 12), atrial flutter (AFl) in 17 and atrial tachycardia (AT) in 11 patients. Long-term AA recurrence rates were evaluated along with the impact of sinus rhythm (SR) maintenance on HF and mortality.

Results
AA recurrence was observed in 14 patients (45%) at a median of 3.5 months (AFib n = 8, AT n = 6, AFl = 0). Post-cardioversion, medical therapy or catheter ablation, 10 patients (32%) remained in permanent AA. Over a median follow-up of 19 months, all-cause mortality was 39% (n = 12): 3 with end-stage HF, 5 due to late complications of CA, 1 sudden cardiac death, 1 stroke, 1 COVID 19 (and one unknown). With maintenance of SR following catheter ablation, significant reductions in serum creatinine and natriuretic peptide levels were observed with improvements in NYHA class. Two patients required hospitalization for HF in the SR maintenance cohort compared to 5 patients in the AA recurrence cohort (p = 0.1). All 3 patients with deaths secondary to HF had AA recurrence compared to 11 out of the 28 patients whom were long-term survivors or deaths not related to HF (p = 0.04). All-cause mortality was not associated with AA recurrence.

Conclusion
This study demonstrates moderate long-term efficacy of SR maintenance with catheter ablation for AA in patients with CA. Improvements in clinical and biological status with positive trends in HF mortality are observed if SR can be maintained.
Preclinical evaluation of Tc-99m p5+14 peptide for SPECT detection of cardiac amyloidosis
Authors: Kennel Stephen J. , Jackson Joseph W. , Stuckey Alan , Richey Tina , Foster James S. , Wall Jonathan S. 
Published: April 2024

Introduction
Amyloid deposition is a cause of restrictive cardiomyopathy. Patients who present with cardiac disease can be evaluated for transthyretin (TTR)-associated cardiac amyloidosis using nuclear imaging with 99mTc-labeled pyrophosphate (PYP); however, light chain-associated (AL) cardiac amyloid is generally not detected using this tracer. As an alternative, the amyloid-binding peptide p5+14 radiolabeled with iodine-124 has been shown to be an effective pan-amyloid radiotracer for PET/CT imaging. Here, a 99mTc-labeled form of p5+14 peptide has been prepared to facilitate SPECT/CT imaging of cardiac amyloidosis.

Method
A synthesis method suitable for clinical applications has been used to prepare 99mTc-labeled p5+14 and tested for peptide purity, product bioactivity, radiochemical purity and stability. The product was compared with99mTc-PYP for cardiac SPECT/CT imaging in a mouse model of AA amyloidosis and for reactivity with human tissue sections from AL and TTR patients.

Results
The 99mTc p5+14 tracer was produced with >95% yields in radiopurity and bioactivity with no purification steps required and retained over 95% peptide purity and >90% bioactivity for >3 h. In mice, the tracer detected hepatosplenic AA amyloid as well as heart deposits with uptake ~5 fold higher than 99mTc-PYP. 99mTc p5+14 effectively bound human amyloid deposits in the liver, kidney and both AL- and ATTR cardiac amyloid in tissue sections in which 99mTc-PYP binding was not detectable.

Conclusion
99mTc-p5+14 was prepared in minutes in >20 mCi doses with good performance in preclinical studies making it suitable for clinical SPECT/CT imaging of cardiac amyloidosis.
Endoscopic Ultrasound–Guided Choledochoduodenostomy With Lumen-Apposing Metal Stent Through Duodenal Stent, a Success Case, and a Salvage Case
Authors: Elmassry Marawan , Haché Billie , Thongpiya Jerapas , Shiratori Yasutoshi , Rateb George 
Published: April 2024

ABSTRACT
Endoscopic ultrasound–guided choledochoduodenostomy (EUS-CD) has become a feasible alternative technique in cases of malignant bile duct obstruction, especially when the endoscopic retrograde cholangiopancreatography is not feasible or has failed. In the case of duodenal obstruction, when a duodenal stent has been initially placed, performing endoscopic retrograde cholangiopancreatography could be quite difficult with a low success rate. Thus, EUS-CD could be a good alternative. In this study, we present 2 particularly challenging endoscopic cases in which EUS-CD was performed with a lumen-apposing metal stent inserted through a previously placed duodenal stent.
Queer Desi Kinships: Reaching Across Partition
Authors: Bahrainwala Lamiyah , Nautiyal Jaishikha 
Published: April 2024

Abstract
This article develops the notion of “queer desi kinships” as a disaporic balm to counter the ravages of Partition, the 1947 separation of India and Pakistan by British imperialism. The term “desi” refers to ethnically South Asian individuals, but broadly translates to “countryperson”—a translation that emphasizes kinship over nation. The two authors offer autoethnographic accounts of their own estrangement from each other in white and Western contexts within academia, and trace its roots to Partitioning that relies on anti-Muslim and anti-queer sentiment, Hindutva, and casteism. In retelling these accounts, the authors tease out queerly desi ways of performing kinship–khamoshi, gham, raazdari–in ways that center non-Western understandings of queerness, and to refuse the whitening and Westernness of queer studies.