bluuebunny/crossref_metadata_2025_split huggingface dataset:
Postnatal Development of Lymphocyte Subpopulations in the Intestinal Lymph Nodes in Goats
Authors: Seva J. , Navarro J. A. , Bernabé A. , Gómez M. A. , Sánchez J. , Gómez S. 
Published: June 2007

SummaryThe incidence and location of CD2+, CD4+, CD8+ and γ/δ T lymphocytes and IgM+ B lymphocytes were studied in the intestinal lymph nodes in 1‐week, 1‐month, 3‐month and 7‐month‐old goats, using monoclonal antibodies and immuno‐histochemical methods. The cortical area of the intestinal lymph nodes in 1‐week‐old animals contains only primary follicles occupied by IgM+ B lymphocytes and some CD2+CD4+ T lymphocytes. In goats older than 1 month, secondary follicles, that increased in number and size with age, were observed; the light zone of the germinal centre was occupied by IgM+ lymphocytes and some CD2+ and CD4+ T lymphocytes. In the other compartments of the lymph nodes, B lymphocytes were scarce, their number increasing with age in the medulla and diminishing in the paracortex. The numerous CD2+ T lymphocytes in the interfollicular area increased in number in the paracortical area of the 7‐month‐old goats, simultaneously with an increase in the MHC II+ dendritic cells and the CD4/CD8 ratio, which was greater than 1. The γ/δ T lymphocytes represented a minor subpopulation scattered through the lymph nodes.
Immunohistochemical Localization of the Spermadhesin AWN‐1 in the Equine Male Genital Tract
Authors: Hoshiba H. , Sinowatz F. 
Published: June 2007

SummarySpermadhesins are proteins with various functions in sperm capacitation and zona pellucida binding. In this study the cellular localization of the spermadhesin AWN‐1 has been examined in the equine male genital tract. Results obtained by immu‐nohistochemical methods reveal that in the horse AWN‐1 is synthesized in spermatogonia, in the rete testis, the ductus epi‐didymidis and the seminal vesicles. These findings indicate that the cellular origin of spermadhesins is species‐specific.
Characterization of Lateral Musculature in the Striped Weakfish (Cynoscion striatus Cuvier)
Authors: Devincenti C. V. , Diaz A. O. , Goldemberg A. L. 
Published: June 2007

SummaryHistochemical and ultrastructural studies were performed on lateral musculature from individual female weakfish (Cynoscion striatus Cuvier). Based upon SDH, PhR, Sudan and myosin‐ATPase determinations, different kinds of red, pink and white fibres were discerned at the anterior, medium and posterior regions. Levels of glycolytic activity increased from red to white fibres, being intermediate in the pink ones. Contrarily, oxidative activity decreased from red to pink and white fibres. Histochemical stain showed a complex distribution of fibre types in each layer. A considerable variation in size and distribution was also found among fibres.
Immunohistochemical Study of Endocrine Cells in the Gastrointestinal Tract of the Philippine Carabao (Bubalus bubalis)
Authors: Baltazar E. T. , Kitamura N. , Hondo E. , Yamada J. , Maala C. P. , Simborio L. T. 
Published: June 2007

SummaryThe distribution and frequency of occurrence of endocrine cells in the gastrointestinal tract of the Philippine carabao (Bubalus bubalis) were studied by immunohistochemistry. Fourteen types of immunoreactive (IR) endocrine cells were revealed. Among the cell types, only chromogranin, serotonin, and bovine pancreatic polypeptide (BPP) were present in the entire gut, while the others showed restricted distribution: somatostatin, gastrin, and cholecystokinin in the abomasum and small intestine; methionine‐enkephalin‐Arg6‐Gly7‐Leu8, motilin, neurotensin, secretin, gastric inhibitory peptide, and substance P in the small intestine; peptide tyrosine tyrosine (PYY) in the large intestine: and glucagon in the whole intestinal tract. Most of the cell types showed peak density in the pyloric, duodenal, or rectal region. The highest cell type heterogeneity was observed in the duodenum. The distribution profile of the gut endocrine cells in the carabao is closely related to that in the Holstein cattle. Important findings include the occurrence of BPP‐IR cells in the entire gut and the high frequency of PYY‐IR cells in the large intestine.
HYPERKERATOSIS LENTICULARIS PERSTANS (FLEGEL): REPORT OF A CASE IN WHICH THE APPLICATION OF BETAMETHASONE‐17‐VALERATE CREAM CAUSED COMPLETE CLEARING OF THE LESIONS*
Authors: Donald G. F. , Hunter G. A. 
Published: June 2007

SummaryThe distinctive clinical and histological features of an extensive case of hyperkeratosis lenticularis perstans and the rapid and complete response to topical applications of betamethasone‐17‐valerate are recorded. No previous record of effective treatment has been described in the four male cases previously recorded in the literature.A 57 year old female has also been studied with a twenty year old history of an unremitting progressive eruption showing the clinical and histological features of hyperkeratosis lenticularis perstans. In this patient initial response to topical therapy with betamethasone‐17‐valerate is most gratifying, and is the first treatment to influence the signs and symptoms of the disease state.
SKIN ELASTIC TISSUE FROM A STUDY OF A CONNECTIVE TISSUE NAEVUS AND RECENT WORK ON CONNECTIVE TISSUES
Authors: Musso L. A. 
Published: June 2007

SummaryThe molecular as well as the electronmicroscopic appearance of elastic tissue is reviewed. The findings in the connective tissue naevus reported in this paper of parallel, partly granular fibrils, with the granules to some extent opposite each other, in the abnormal elastic fibres are described. Their significance for the fine structure of normal skin elastic fibres is discussed.With the aid of the suggested mode of formation of a similar elastomer, resilin, as well as what constitutes form in biological tissue, the implication of the above findings for the formation of elastic tissue in the skin is considered.
Short‐Term Observations in the Use of Intravenous Methotrexate in the Treatment of Psoriasis*
Authors: Land W. A. 
Published: June 2007

SummaryThe mechanism of folic acid antagonist drugs in the treatment of psoriasis is discussed The effects of therapy with one of these drugs, intravenous methotrexate, are reported One fatality is described, all the remaining patients being cleared by treatment, for an average period, of about one month. Apart from the fatality in a patient with renal damage not detected by laboratory tests, side effects of therapy were minimal.
Extravascular Tissue Factors in Purpura*
Authors: Kocsard B. 
Published: June 2007

SummaryStudy of the extravascular tissue factors contributing to purpuric manifestations of dermatoses might be of some help in their understanding, and could give hints of differential diagnostic importance. The various macroscopic and microscopic tissue factors contributing to the manifestations of dermatological purpuras are reviewed. While the importance of the vessel fragility factor is often stressed when the pathogenesis of dermatological purpuras is considered, the extravascular tissue factor is very often neglected. Although this tissue fragility factor is intimately bound up with the vessel fragility factor, one should strive to dissociate the two. Intracutaneous injections of the patient's own blood or of dye solutions may be of help in doing so.
Aspects of Carcinogenesis in Solar Damaged Skin
Authors: Mitchell R. E. 
Published: June 2007

SUMMARYA light and electronmicroscopical study has been made of 16 premalignant and malignant lesions arising in solar damaged skin. Cells which differ from normal basal keratinocytes and melanocytes, and from definitive cancer cells, have been seen in basal regions of the epidermis in premalignant conditions, and at the periphery of cancers. Changes in the basement membrane and in the superficial dermis which were peculiar to the individual lesions also occurred and their significance is discussed. A similarity in the fine structure of premalignant lesions arising in solar damaged skin and in the early stages of experimental chemical skin carcinogenesis is noted. These observations support the theory that cancers in solar damaged skin develop from a gradual and sometimes a multicentric change in the epidermal cells.
Cutaneous Manifestations of Systemic Lupus Erythematosus
Authors: Tay C. H. 
Published: June 2007

SUMMARYSixty two cases of SLE were studied in a Medical Unit for a period of 4 years. Four different aspects of the cutaneous manifestations were analyzed and discussed. Butterfly rash, alopecia and photosensitive lesions were slightly more common than in Western series, whereas, Raynaud's phenomenon, discoid lesions and others were rarely found. Some other uncommon lesions, especially one case with bullae formation, one with gangrene of toe and another with subcutaneous calcinosis, were observed. Psoriasiform lesions and hyperkeratotic lesions were also found in this series.Skin lesions secondary to systemic disorders and therapy were also studied and the findings discussed.
Death from Coronary Calcinosis Occurring in the Baby of a Mother Presenting with Pseudoxanthoma Elasticum*
Authors: Hamilton‐gibbs J. S. 
Published: June 2007

SUMMARYThis paper reports the case of a baby with coronary calcinosis born to a mother suffering from pseudoxanthoma elasticum.The aetiology of infantile coronary calcification is discussed, and the point is made that the dystrophic type is a disease of elastic tissue.Both conditions are rare genetic diseases and show dystrophic changes of the elastic tissue.
Mammary and Extramammary Paget's Disease
Authors: Mitchell Ruth E. 
Published: June 2007

SUMMARYTwo cases of mammary and one case of vulval Paget's disease are studied histologically and electronmicroscopically. There are no substantial morphological differences between those two types.The Paget cell has a characteristic fine structure: it lacks tonofibrils and shows many of the features of apocrine cells. Less highly differentiated keratinocytes lie adjacent to Paget cells and desmosomes exist between them. These observations suggest that Paget cells differentiate in situ from epidermal cells.
Cutaneous Manifestations of Arsenic Poisoning Due to Certain Chinese Herbal Medicine*
Authors: Tay C. H. 
Published: June 2007

SUMMARYCertain brands of Chinese herbal preparations, especially those employed for the treatment of bronchial asthma, were found in Singapore to contain toxic amount of inorganic arsenical compounds, and were responsible for 74 recent cases of acute, subacute and chronic poisonings.The majority (92%) of these cases demonstrated cutaneous manifestations, chief of which were generalized hyperpigmentation of the trunk (85%), hyperkeratoses of the palms and soles (65%),‘raindrop’ depigmentation (31%), and hyperhidrosis of the palms and soles (31%). Localized areas of pigmentation on the hands, feet, elbow, neck and face were found in 17 milder cases. Severe cases with long‐standing illness had multiple pigmented keratoses on the trunk and limbs (23%) and five patients (6%) eventually developed cutaneous malignancies in the form of multiple pigmented basal cell carcinomata or Bowen's disease (5%) and one squamous cell carcinoma (1%). Four of the cases also demonstrated multiple visceral cancers affecting the lungs, vocal chord, gallbladder and liver. Uncommon skin lesions found included hypersensitivity rashes (16%), mucous membrane irritation (8%), and alopecia (5%). In addition 19 patients with atopic dermatitis, four with corticosteroid skin eruptions from simultaneous systemic steroid administration prescribed by the ‘sinsehs’ and two with cutaneous side‐effects from dimercaprol therapy, were seen.
PHOTOSENSITIVE BULLOUS ERUPTION ASSOCIATED WITH CHRONIC RENAL FAILURE*
Authors: Rotstein Harvey 
Published: June 2007

SummaryEight patients with chronic renal failure developed blisters similar to those seen in porphyria cutanea tarda. However, porphyrin studies were normal and neither scarring nor milia were seen in these patients. Blistering appeared to be induced by minor trauma to light exposed areas on the dorsa of the hands and feet, and intensity of sunlight seemed more related to blister production than either the type or severity of renal disease or the patient's medication. The blisters were produced by a split at the dermo‐epidermal junction just above the PAS basement membrane zone. The upper dermal blood vessels within the region were thickened by the accumulation of PAS positive material. Although there was little cellular infiltrate, many degranulated mast cells were present in the mid‐dermis. Deviating calciphylaxis may have been associated with these changes.
ACQUIRED JUVENILE HYPOTHYROIDISM PRESENTING WITH NAIL CHANGES
Authors: Keipert James A. , Kelly Robert 
Published: June 2007

SummaryOnycholysis and other nail changes are occasionally found in association with hypothyroidisin in adults, but no previous report has been found of nail changes as a presenting feature of primary acquired hypothyroidism n a child (who also has a unique combination of endocrinopathies and other disorders).
THE INVESTIGATION OF PATIENTS WITH LIVER DISEASE AND THE ROLE OF NEW INVESTIGATIONS*
Authors: Cooksley W. G. E. 
Published: June 2007

SummaryThe investigation of patients with suspected liver disease requires a logical approach to diagnostic decision making. Answers to the following questions are needed‐Is hepatobiliary disease present? What is the diagnosis? What is the prognosis? A sequential approach to investigation is advocated including a two step process for the elucidation of the diagnosis. The principles expounded are readily applied to new investigations and their current role is discussed.
A NEW SUCCESSFUL APPROACH TO TRACE METAL THERAPY AND ITS RELEVANCE TO THE AETIOLOGY OF VARIOUS SKIN DISORDERS*
Authors: Bauer F. 
Published: June 2007

SummaryPatients with dermatitis herpetiformis, chronic prurigo of adults and bullous pemphigoid reported in this study have responded more effectively to their specific drug therapy if trace metal supplement were provided. A lesser dosage requirement or even final elimination of drugs like dapsone or corticosteroids, resulted. Most frequently, a zinc and magnesium mixture was prescribed, although zinc only or magnesium only mixture was given in some patients. The plasma zinc and plasma magnesium levels in these patients were frequently below normal or in the low normal range.
TOPICAL STEROIDS AND HYPOTHALAMO‐PITUITARY‐ADRENAL SUPPRESSION: A REVIEW*
Authors: Bartley Paul C. 
Published: June 2007

SummaryPotent topical corticosteroids have been documented as causing Cushing's syndrome and hypothalamo‐pituitary‐adrenal suppression. This can be minimized by restriction of potent preparations to specialists and by using these compounds for a minimum, but effective period. If potent corticosteroids are used for prolonged periods, then hypothalamo‐pituitary suppression should be excluded or confirmed by a metyrapone test.
THE EFFECT OF BETAMETHASONE DIPROPIONATE CREAM 0.05% (DIPROSONE) ON ADRENOCORTICAL FUNCTION
Authors: Downie D. A. W. , Cains G. D. , Peek R. D. 
Published: June 2007

SummaryThis study was conducted with 16 subjects to determine whether the topical application of betamethasone dipropionate (Diprosone) 0.05% cream, in amounts of 30 or 60 g daily for a period of four weeks, would lead to adrenocortical suppression. Five patients were given 60 g daily, six patients given 30 g daily and five normal subjects 30 g daily. Adrenocortical function was assessed weekly by means of plasma cortisol levels. The results showed that transient adrenocortical suppression may follow the use of betamethasone dipropionate 0.05% cream daily at these dosage levels and this may be a function of heightened absorption in some individuals.It is intended to carry out a further trial using both plasma cortisol determination and insulin‐induced hypoglycaemia as a measure of hypothalamus‐pituitary‐adrenal axis suppression, as it is believed that minor and moderate degrees of adrenal suppression may not become obvious from plasma cortisol determinations.
NAIL GROWTH IN ANTARCTIC REGIONS
Authors: Gormly P. J. , Ledinghamf J. E. 
Published: June 2007

SummaryFinger nail and great toe nail growth was observed in 42 subjects: 28 over 11 months of an expedition at an Antarctic Station and 14 over 10 months on a Sub‐antarctic island. The mean rates of finger nail growth were 109.8μm per day and 106.4 μm per day respectively, and great toe nail growth was approximately half the finger nail growth at both locations.These findings confirm that nail growth in Antarctic regions is comparable to that in temperate climates with no significant differences during colder months or in different cold locations. The relatively high rate of toe nail growth may be due to a hot‐house effect from almost constant use of insulating footwear.
MULTICENTRIC RETICULOHISTIOCYTOSIS: A LIGHT AND ELECTRON MICROSCOPIC STUDY
Authors: Heenan Peter J. , Quirk Christopher J. , Spagnolo Dominic V. 
Published: June 2007

SummaryMulticentric reticulohistiocytosis (MR) with typical skin lesions and arthritis developed in a 51 year old woman. The cutaneous papules and nodules contained a dermal infiltrate of histiocytes and giant cells with ground‐glass cytoplasm. Invagination of elastin and collagen by MR cells was demonstrated by both light and electron microscopy. The patient responded well to treatment with chlorambucil but was subsequently found to have a rapidly disseminating carcinoma of the breast.
A PILOT STUDY OF A SUPPORT GROUP FOR PARENTS OF CHILDREN WITH ECZEMA
Authors: Skimming Jose Mc , Gleeson Louise , Sinclair Merrianne 
Published: June 2007

SUMMARYThe parents of children with atopic dermatitis often require considerable encouragement and support to help them cope with this distressing and potentially disabling condition. Over a period of two months a time limited support group was established for parents of children with eczema at the Royal Alexandra Hospital for Children in response to a perceived need for parental support, self help and the alleviation of feelings of isolation and not coping.
BULLOUS PEMPHIGOID: CLINICO‐EPIDEMIOLOGICAL STUDY OF PATIENTS SEEN AT A SINGAPORE SKIN HOSPITAL
Authors: Tham S. N. , Thirumoorthy T. , Rajan V. S. 
Published: June 2007

SummaryA retrospective study of 37 patients with bullous pemphigoid was conducted at the Middle Road Hospital. The mean age of onset was 58.4 years. There was no significant difference in the incidence between males and females. Singaporeans of Indian origin had a higher incidence of bullous pemphigoid. There was no significant association with internal malignancy.The commonest immunoreactant detected at the basement membrane zone (BMZ) was C3 (87.8 %). There was no correlation between the titre of serum anti BMZ antibody and the clinical activity of the disease. There were nine deaths in this group (24 %). Only two patients (22%) had active skin lesions at the time of death.
REVERSE HALO NAEVUS
Authors: Paver Ken , Salmon Robert 
Published: June 2007

SummaryAn occult naevus associated with a halo of depigmentation is described in a ten year old boy. The development of three lesions in this boy supports the concept that the development progressed from leucoderma to halo naevus to normal pigmented naevus instead of the progression from pigmented naevus to halo naevus to leucoderma as is normally found.
PORPHYRIA CUTANEA TARDA IN A SEVEN YEAR OLD CHILD
Authors: Rogers M. , Kamatht K.R. , Poulost V. 
Published: June 2007

SummaryA case of porphyria cutanea tarda in a seven year old child is reported. This was demonstrated to be a familial type by uroporphyrinogen decarboxylase estimations in the patient and her family. Treatment of the patient with chloroquin is described.
CATECHOLAMINE EXCRETION IN PATIENTS WITH PSORIASIS*
Authors: Ellis Vivienne M. 
Published: June 2007

SummaryThe twenty‐four hour urinary excretions of the catecholamines were measured in 39 psoriatic patients and compared with the results obtained for 97 healthy volunteers from a previously published study using a similar technique. The psoriatic patients showed significantly lower adrenalin levels (p<0.001) and significantly higher noradrenalin (0.001<p<0.01) and dopamine levels (p<0.001). A significant positive correlation (p<0.05) was found between adrenalin excretion and % skin involvement. These preliminary findings lend further support to the theory of cyclic nucleotide axis involvement in the aetiology of psoriasis.
BENEFICIAL EFFECT OF CORTICOSTEROID THERAPY IN MICROSPORUM CANIS KERION
Authors: Keipert James A. 
Published: June 2007

SummaryOral corticosteroid therapy has been reported to produce a rapid recovery in trichophyton kerion. In this paper three children are described with kerion due to Microsporum canis. The inflammatory changes responded dramatically to oral corticosteroid therapy with rapid healing of the kerions. The immunological basis for kerion formation and the response to corticosteroid therapy is discussed.
MULTIPLE HAMARTOMA SYNDROME WITH TRICHOEPITHELIOMAS AND BASAL CELL CARCINOMAS
Authors: Cowen P. , Connors T. 
Published: June 2007

SUMMARYA patient with multiple hamartomas developed severe disfiguring trichoepitheliomas on her face. Some years later she developed multiple basal cell carcinomas.The occurrence of trichoepitheliomas with multiple hamartoma syndrome has not previously been reported.This patient with trichoepitheliomas developed undoubted basal cell carcinomas without the other major features of basal cell naevus syndrome. There do, however, appear to be some similarities between basal cell naevus syndrome and multiple hamartoma syndrome and this issue is addressed.
TRAUMATIC NASAL LEUCODERMA IN CHILDHOOD
Authors: Keipert James A. 
Published: June 2007

SUMMARYFour children have been seen with a white line across the nose due to leucoderma in a transverse nasal crease, both of which are due to the habit of pushing up the tip of the nose with the palm or fingers. The parents are usually worried about the cosmetic defect but often have not realised the relation between the habit and the white line, or had not registered that the child had the habit, so that recognition and reassurance depend on appreciation of the cause, which may not be suggested by the history.
MULTIFOCAL FIBROSCLEROSIS: CUTANEOUS ASSOCIATIONS
Authors: Fischer G. O. , de Launey W. E. 
Published: June 2007

SummaryThere is a group of disorders characterized by simultaneous and progressive fibrosis of several discrete regions of the body. This disease complex, “multifocal fibrosclerosis”, most commonly involves the retroperitoneal and mediastinal compartments and may be accompanied by cutaneous lesions. In most cases the aetiology is unknown but there is good evidence, supported by the patient we describe, for a vasculitic origin in a significant proportion of patients.We report a case of multifocal fibrosclerosis associated with cutaneous lesions. These included livedo reticularis and recurrent, painful nodules and pustules on the legs and feet, which progressed to chronic ulceration. Histologically there was evidence of an underlying necrotising vasculitis.A review of the cutaneous changes that have been reported in association with multifocal fibrosclerosis allows speculation regarding the aetiology of the disease process.
FIXED DRUG ERUPTION DUE TO METHAQUALONE
Authors: Heng Madalene C. Y. 
Published: June 2007

SummaryA patient with a fixed drug eruption due to methaqualone ingestion is described. Attention is focused on the involvement of identical areas of the skin in two previous episodes, on the progressive increase in extent and severity with each episode, and on the shortening of the time interval between the ingestion of the drug and the development of clinical symptoms and lesions. These findings, together with the pain which preceded the appearance of the clinical lesions, and the presence of many neutrophils in the dermal infiltrate, support the current theory of antibody‐dependent cytotoxic mechanisms in the pathogenesis of fixed drug eruptions.