bluuebunny/crossref_metadata_2025_split huggingface dataset:
PEMANTAUAN DAN EVALUASI TEKNOLOGI INFORMASI DI PEMERINTAH KABUPATEN GRESIK BERDASARKAN PERATURAN MENTERI PAN-RB NOMOR 59 TAHUN 2020
Authors: Dewi Renny Sari , Astiarasanti Amelia Hayyu , Fahmi Fiqih Zulfikar 
Published: March 2024

Abstract
Central government agencies until the current local government have started to implement an electronic-based governance system (SPBE). SPBE is a government organization that utilizes information and communication technology to provide services to SPBE Users. The government has established SPBE guidelines stipulated in Presidential Regulation No. 95 of 2018 on SPBE and to ensure the implementation of SPBE can run to achieve its objectives to realize an integrated and comprehensive government set forth The Ministerial Regulation of PAN-RB No. 5 of 2018 concerning SPBE Evaluation Guidelines. In 2019, the Ministry of PAN-RB conducted SPBE evaluation activities through the SPBE self-assessment method and obtained SPBE index results worth 3.14 on a scale of 0-5 and entered into the GOOD predicate. From these results, the Gresik district government needs to improve the quality of SPBE. In September 2020 the Government again established The Ministerial Regulation of PAN-RB No. 59 of 2020 concerning the monitoring and evaluation of SPBE. The regulation has been listed 4 Domains, 8 Aspects, and 47 indicators to assess the maturity level of SPBE. The result of the evaluation maturity level of SPBE evaluation of Gresik district government based on Regulation of the Minister of PAN-RB Number 59 of 2020 is 2.54. Interpretation of the value of maturity level is included in the Predicate Enough is the level of maturity of the process capability occupied level 2 (managed) and the level of service capability occupied level 2 (Interaction).
Keywords: SPBE; Monitoring and Evaluation; IT Audit; Ministerial Regulation of PAN-RB Number 59 of 2020
ANALISIS DAN DESAIN SISTEM APLIKASI KANTIN ELEKTRONIK (E-CANTEEN) BAGI MAHASISWA DAN STAFF UNIVERSITAS
Authors: Cahyani Putri Rigita , Maylinasari Lely , Ambami Sinta Aisyah , Putra Bagaskara Rahadi 
Published: March 2024

The E-Canteen application is an innovative solution that aims to change the traditional way of managing canteens into a more efficient and practical process through digital technology. This application allows students and staff to order food online via mobile devices or computers. In managing traditional canteens, there are often long queues and a waste of time in ordering food. In addition, sometimes, there is a mismatch between the available food stock and the user's wishes. The E-Canteen application is here to solve these problems by providing efficient and practical solutions.
Artrite Psoriática e o seu Desafio Diagnóstico: Relato de Caso
Authors: Garuta Ina , Barros Cardoso Sérgio , Terroso Lira Luís , Magalhães Alice , Cerqueira Marcos , Paulo Costa Luís 
Published: March 2024

A artrite psoriática (AP) apresenta-se, habitualmente, como uma oligoartrite ou monoartrite, e pode constituir um desafio diagnóstico na ausência de história de psoríase.Relata-se o caso de um paciente de 57 anos que recorreu ao Médico de Família (MF) após um ano de evolução de sinais inflamatórios e onicólise do 3º dedo da mão direita. Os exames iniciais mostravam sinais inflamatórios dos tecidos peri-ungueais até à articulação interfalângica distal, e parâmetros inflamatórios analíticos negativos. O quadro foi interpretado em contexto infecioso e, posteriormente, como osteoartrose, não tendo existido melhoria com os tratamentos instituídos. A doença e o atraso no diagnóstico tiveram significativo impacto psicológico e profissional no paciente.Este caso relata uma apresentação rara de AP, podendo aumentar a suspeição diagnóstica desta entidade nos Cuidados de Saúde Primários, e evidencia o papel do MF no acompanhamento holístico e gestão das expectativas do paciente, além da articulação com as outras especialidades.
Um Caso de Delírio de Infestação nos Cuidados de Saúde Primários
Authors: João Sara , Albuquerque Rui Pedro , Lemos Inês 
Published: March 2024

O delírio de infestação é uma perturbação que se caracteriza pela crença persistente de infestação por organismos vivos ou inanimados na ausência de evidência para tal. Perante as queixas é frequente os doentes recorrerem primeiramente ao médico de família ou a um dermatologista, ao invés de um psiquiatra, por não acreditarem que os seus sintomas são delirantes.Descrevemos o caso de uma doente de 86 anos que recorreu aos cuidados de saúde primários com história de ideias delirantes de infestação, acompanhadas de alucinações visuais e cenestésicas.Após investigação etiológica, o caso foi discutido com um colega de Psiquiatria do hospital da área de residência. Assumido o diagnóstico de delírio de infestação, foi iniciada terapêutica com risperidona, verificando-se a remissão completa dos sintomas.Este caso pretende alertar para a necessidade de os médicos de família reconhecerem esta patologia de forma a poderem orientá-la corretamente. Reforça ainda a importância da comunicação entre várias especialidades na gestão de perturbações semelhantes, que envolvem diagnósticos menos comuns, mas cuja abordagem inicial pode ser feita nos cuidados de saúde primários, desde que haja validação pela especialidade em questão.
Learning Disabilities and Epilepsy: About a Clinical Case
Authors: Freitas Fernandes Carolina , Ferreira Gonçalves Carolina , Rego Sousa Paulo 
Published: March 2024

Landau-Kleffner syndrome (LKS) is an epilepsy syndrome of childhood, characterized by auditory verbal agnosia and severe electroencephalographic abnormalities. It happens between 3-7 years of age, 20% without seizures. A 6-years-old boy, with normal psychomotor development, who begins to experience difficulties in understanding the meaning of words, sometimes with incoherent speech and writing difficulties (irregular handwriting, spelling mistakes). Neurological evaluation showed loss of comprehensive language with auditory verbal agnosia, difficulties in fine motor skills and in graphomotor coordination. After clinical suspicion, the diagnosis of SLK was confirmed by night video-electroencephalogram (EEG): abundant paroxysmal activity of bilateral and independent fronto-center-temporal spikes and spike-wave activity, with an almost continuous exacerbation during sleep. Initially treated with valproate and clobazam, without improvement, he started prednisolone, with improvement in language, writing and normalization of the EEG. Knowledge of this syndrome is important for differential diagnosis with other neurological disorders, especially learning difficulties.
Hyperbaric Oxygen Therapy as a Complementary Treatment for Osteoradionecrosis of the Mandible: Useless or Useful? - A Literature Review
Authors: Alpuim Costa Diogo , Arana Ribeiro Joana , D'Espiney Amaro Carla 
Published: March 2024

Radiotherapy (RT) is a key component of managing head and neck cancer patients. However, despite the emer gence and improvement of new RT techniques, late complications may occur, such as osteoradionecrosis of the mandible (ORNM). The diagnosis is based on clinical/radiological criteria. In the established ORNM, the chronic process does not solve spontaneously, and optimal management still needs to be established. Over the last decades, a broad therapeutic spectrum has been considered, including hyperbaric oxygen therapy (HBOT). Al though, the clinical impact of HBOT varies according to the literature, which is why there is a current controversy regarding its benefits. Further prospective and randomised studies are needed to validate its effectiveness in the ‘real-world’ clinical practice. This article aims to synthesise the existing data, analyse previous studies´ results, identify gaps in knowledge, and discuss ORNM’ management, including a proposal for an algorithm, with a par t icular focus on HBOT.
Ensino remoto de educação em saúde na pós-graduação em saúde coletiva: possibilidades no contexto da pandemia de covid-19
Authors: Pereira Deborah Santana , Morais Ana Patrícia Pereira , Pequeno Alice Maria Correia , Guimarães José Maria Ximenes 
Published: March 2024

O ensino remoto emergencial ocasionou mudanças no processo de ensino-aprendizagem, requisitando criatividade e incorporação de novas estratégias pedagógicas. Objetivou-se relatar experiência de ensino-aprendizagem de “Educação em Saúde”, num Programa de Pós-Graduação em Saúde Coletiva. Trata-se de um relato de experiência sobre o ensino remoto de Educação em Saúde na pós-graduação strito senso em Saúde Coletiva, de uma Universidade pública cearense, no período letivo 2021.1. A disciplina foi ministrada por meio da plataforma Google Meet®, com a adoção de estratégias ativas de ensino-aprendizagem. Evidenciou-se que os conteúdos foram relevantes, estabelecendo-se articulação teórico-prática e respeitando-se aos saberes prévios dos pós-graduandos. Buscou-se superar o modelo tradicional de ensino, com vistas a promover aprendizagem significativa. Os desafios e as possibilidades identificadas permitem a reflexão sobre a práxis docente, no que tange o estímulo à participação e engajamento discente em ambiente virtual, além da incorporação de estratégias ativas de ensino, sobretudo no ensino remoto.
Some aspects of laboratory diagnostics of ophthalmodemodecosis
Authors: Popova D. A. , Kursakova Yu. V. 
Published: March 2024

Demodicosis occupies a leading position among all dermatoses. According to ICD-10, it is not distinguished as a separate disease; it belongs to the class of parasitic diseases. The relevance of studying the problem of ophthalmodemodecosis is caused by its high prevalence and contagiousness, chronic course, an open issue of the role of the Demodex mite in the occurrence of inflammatory eye diseases, as well as the lack of effective methods for treating and preventing this pathology. In addition, Demodex causes discomfort and contributes to the occurrence of cosmetic defects, which in turn worsens the patient’s quality of life.The aim. To present a review of the literature data and our own results of laboratory diagnostics of ophthalmodemodecosis.Materials and methods. The article presents clinical cases of demodectic eyelid lesions with different disease outcomes in case of similar treatment. Laboratory diagnostics included drawing up an acarogram. Epilated eyelashes were used as a material for detecting mites on eyelids. Counting of individuals was carried out using light microscopy; all forms of mite development were taken into account. The work presents the statistics on the frequency of examination of patients with suspected demodicosis at different times of the year, confirming the seasonality of this disease. The literature review included data on the history of studying the Demodex mite, existing hypotheses and theories about its pathogenesis, as well as the information on domestic and foreign methods of treating ophthalmodecosis, including modern hardware techniques.Results. Demodex mites play a significant role in the development of blepharitis and blepharoconjunctivitis. It is important to consider that demodicosis can occur against the background of inflammatory eye diseases of another etiology. Therapy for ophthalmodemodecosis currently remains complex, lengthy and ineffective. When assessing the results of an acarogram, any detected stages of a mite are clinically significant, and there isn’t a direct relationship between the number of detected mites and the severity of clinical manifestations in all cases.
Organizational aspects of medical rehabilitation of patients with respiratory tuberculosis
Authors: Siraeva T. V. , Komissarova O. G. , Romanov V. V. 
Published: March 2024

Background. Despite the visible successes of domestic phthisiology at the present time, the problem of medical rehabilitation of patients with tuberculosis remains relevant. In recent years, approaches to medical rehabilitation of patients with various diseases have changed significantly, which entail the need to consider a complex of rehabilitation measures for patients with tuberculosis from the perspective of the Procedures for organizing medical rehabilitation in adults and children and their integration into phthisiatric practice.The aim. To study the organizational aspects of medical rehabilitation of patients with respiratory tuberculosis in the world and the Russian Federation.Methods. We carried out an analysis of domestic and foreign literature, regulatory documents on the organization of rehabilitation for tuberculosis patients for 2018–2023 in electronic databases PubMed/Medline, Google Scholar using terms “tuberculosis, pulmonary/rehabilitation” in English and Russian languages.The results show a growing amount of factual information demonstrating the positive effect of pulmonary rehabilitation in patients with respiratory diseases, including tuberculosis. The analysis revealed defects in the organization of the medical rehabilitation system in the structure of medical care for tuberculosis patients in the Russian Federation. This concerns problems of routing, phasing, organizational models, human and material resources, standardization of the main components of the rehabilitation process, the significance and effectiveness of certain rehabilitation measures, which leads to low availability of rehabilitation care for tuberculosis patients. Deficiencies in the regulatory framework prevent the integration of medical rehabilitation into the practice of TB services.Conclusion. Modern issues of organizing rehabilitation care for patients with tuberculosis require further study and improvement. The development of a system of medical rehabilitation of patients with tuberculosis helps to increase the effectiveness of treatment, to reduce the number of complications, disability, mortality due to tuberculosis, and to increase the duration and quality of life of patients.
Lysophosphatidic acid and itsreceptors: Role in bronchial asthma pathogenesis
Authors: Kytikova O. Yu. , Novgorodtseva T. P. , Denisenko Yu. K. 
Published: March 2024

Lysophosphatidic acid (LPA) is a biologically active lipid mediator that regulates a number ofsignaling pathways involved in the pathogenesis of bronchial asthma. Attention to studying the relationship of LPA with LPA receptors (LPARs) and ion channels with transient receptor potential (TRP) is caused by their role in the initiation and development of bronchial obstruction, which suggests the development of new effective strategies for the treatment of bronchial asthma through blocking LPA synthesis and/or regulation of the activity of the ligand-receptor relationship.The aim of the review. To summarize ideas on the role of lysophosphatidic acid and its receptors in the pathogenesis of bronchial asthma based on the analysis of articles published in English in 2020–2023 from the PubMed database.Conclusion. The review summarizes recent literature data on the chemical structure, biosynthetic pathways and LPA receptors. It presents the information on the role of LPA, LPARs andTRP channels inthepathogenesis of bronchial asthma; summarizes the bronchial asthma therapeutic strategies targeting LPA, LPARs, andTRP channels. The review highlights not only a new perspective on understanding the mechanisms of initiation of asthmatic reactions, but also possible ways to manage them at the stage of correction of their development.
Restoration of adaptive cardioprotection impaired by metabolic syndrome in rats by the PPARα activation
Authors: Naryzhnaya N. V. , Derkachev I. A. , Kurbatov B. K. , Sirotina M. A. , Kilin M. , Maslov L. N. 
Published: March 2024

Background. It is known that the protective effect of adaptation and conditioning influence is weakened in animals with metabolic syndrome. Metabolic syndrome may be the basis for the failure of cardioprotection in clinical settings.The aim of the study. To identify the relationship between disorder in carbohydrate and lipid metabolism and a decrease in the effectiveness of the infarct-limiting effect of moderate chronic normobaric hypoxia; to check the possibility of correcting reduced cardioprotection by normalizing carbohydrate and lipid metabolism.Methods. The study included 64 Wistar rats. Metabolic syndrome was induced by feeding animals a high-carbohydrate, high-fat diet for 84 days. Chronic normobaric hypoxia was carried out for 21 days in the following mode: 12 % O2 : 0.3 % CO2. Metformin at a dose of 200 mg/kg/day or PPARα agonist WY14643 at a dose of 1 mg/kg/day were added to the drinking water of rats with metabolic syndrome during adaptation period to hypoxia. A 45-minute coronary occlusion and 120-minute reperfusion were performed, and the infarct size was determined. Indicators of lipid and carbohydrate metabolism, leptin, and adiponectin were studied in the blood serum.Results. The infarct-limiting effect of chronic normobaric hypoxia was weakened in animals with metabolic syndrome. Infarct size showed a direct correlation with decreased glucose tolerance and serum triglyceride levels. Using metformin therapy did not lead to the restoration of the infarct-limiting effect of chronic normobaric hypoxia, while the normalization of lipid metabolism with the use of the PPARα agonist WY14643 corrected the impairment of adaptive cardioprotection in rats with metabolic syndrome.Conclusion. The lack of cardioprotection at chronic normobaric hypoxia in rats with metabolic syndrome is associated with impaired carbohydrate and lipid metabolism. The PPARα agonist restores impaired lipid metabolism and adaptive cardioprotection.
Prevention and correction of behavioral disorders in rats with metabolic syndrome using a complex phytoadaptogen
Authors: Dzampaeva Zh. V. , Datieva F. S. , Takoeva E. A. , Nartikoeva M. I. 
Published: March 2024

The aim of the study. To assess the possibility of correction and prevention of behavioral disorders in rats with metabolic syndrome using a complex phytoadaptogen (CPA).Material and methods. The experiment was carried out on 30 male Wistar rats randomized into 3 groups: group 1 – control; group 2 – metabolic syndrome (MS); group 3 – treatment of metabolic syndrome using CPA. In groups 2 and 3, animals were on a high-carbohydrate and high-fat diet for 16 weeks. Group 3 received CPA for 14 days in drinking water after 16 weeks of a diet. CPA consists of official tinctures of Glycyrrhiza glabra, Rhodiola rosea, Acantopanax senticosus at a ratio of 1:2:1. Behavior was analyzed through the “open field” test using Realtimer software (Open Science, Russia). Data were analyzed using GraphPad Prism 8.03 software (GraphPad, USA).Results. The experiment proved that metabolic syndrome is accompanied by increased anxiety (decreased horizontal (p = 0.017) and vertical (p = 0.017) motor activity) and fear (increased periods of immobility (p = 0.011)) in the open field. When corrected with a complex phytoadaptogen, the time spent in the open and closed arms of the maze did not differ statistically significantly from the values of similar control indicators.Conclusion. Based on the data obtained in the group 3 (no statistically significant differences with control) – decreased manifestations of fear and anxiety (increased orientation and research activity) – we can talk about the effectiveness of complex phytoadaptogens as an anxiolytic. The mechanisms underlying this result remain to be explored, emphasizing the role of the autonomic nervous system, leptin and ghrelin in behavior and the influence of complex phytoadaptogens on them.
Association of FoxP3<sup>+</sup> T regulatory lymphocytes with epicardial adipose tissue thickness in patients with coronary heart disease
Authors: Kologrivova I. V. , Kharitonova O. A. , Dmitriukov A. A. , Kravchenko E. S. , Koshelskaya O. A. , Suslova T. E. 
Published: March 2024

Background. Increase ofthe epicardial adipose tissue (EAT) thickness isassociated with development of inflammation and cardiovascular complications, however, there is no data on the relationship between EAT thickening and the number of immunosuppressive regulatory T lymphocytes.The aim. To study the number of circulating T regulatory lymphocytes and nuclear translocation ofthe FoxP3 transcription factor in patients with stable coronary heart disease (CHD) depending on the epicardial adipose tissue thickness.Materials and methods. We examined 30 patients with chronic stable CHD. The EAT thickness was measured by echocardiography. Patients were divided into groups depending on the presence and absence of EAT thickening above 5 mm (groups 1 and 2, respectively). Imaging flow cytometry was used to determine the number of T regulatory lymphocytes and the level of FoxP3 nuclear translocation. The concentration of cytokines and high sensitivity C-reactive protein (hsCRP) was determined using enzyme-linked immunosorbent assay in blood serum.Results. Anthropometric indicators of obesity and the severity of atherosclerosis were comparable between groups. In group 2, there was an increase in low-density lipoprotein cholesterol concentration (p = 0.043), ratio of low-density lipoprotein cholesterol tohigh-density lipoprotein cholesterol (p = 0.017) and the concentration ofhsCRP (p = 0.044) andIL-1β (p = 0.005), adecrease in the number and relative count of Tregulatory lymphocytes (p = 0.020 andp = 0.026, respectively), aswellas thenumber of cells withFoxP3 nuclear translocation (p = 0.018) compared togroup1. According tomultiple logistic regression, the concentration ofhsCRP, IL-1β and T regulatory lymphocytes relative count in total were the predictors of EAT thickening (accuracy 80 %; sensitivity 75 %; specificity 84,6 %; AUC = 0.89).Conclusions. Thickening of epicardial adipose tissue inpatients withcoronary heart disease is associated with a decrease in the number of T regulatory lymphocytes andFoxP3 nuclear translocation inthem in presence of comparable anthropometric parameters of obesity and the severity of coronary atherosclerosis.
Governance And Digital Transformation: Analisis Ruang Kerja Virtual Melalui Perspektif E-Government Pada Pemerintahan Provinsi Bali
Authors: Ni Putu Kartika Cahyani  , I Putu Adi Permana Putra  
Published: March 2024

Digital transformation in the government sector is a form of public service innovation. Since the COVID-19 pandemic, various digital-based innovations have emerged as solutions to the problems that occur. This effort was made to provide services to the community during the pandemic. One of them is the presence of a virtual office as a work space platform that supports efficiency in providing public services. Virtual offices are a manifestation of an electronic-based government system (SPBE), administering government by utilizing technology, information, and communication. This system exists to realize effective, efficient, transparent, and accountable government governance. This article focuses on reviewing virtual offices as a digital-based public service from an e-government perspective. The study uses a qualitative descriptive approach with data collection techniques through literature studies, such as books, journal articles, websites, and other documents related to the research topic. The results of this research show that virtual offices are a form of government governance through digital transformation. A review from an e-government perspective shows that this system has demonstrated key elements in achieving successful e-government implementation. Among them are support, capacity, and value. Apart from that, the concept of dynamic governance shows that the virtual office is a form of transformational government governance that is able to answer the challenges of technological and information development. This supports dynamic government towards good governance.