bluuebunny/crossref_metadata_2025_split huggingface dataset:
Die kristall und molekulstrük tur des 2,3,7,8‐tetrachlorphenazins
Authors: Riganti Vincenzo , Locchi Stelio , Curti Renato , Bovio Bruno 
Published: March 2009

AbstractDie Kristall‐ und Molekülstruktur des 2, 3, 7, 8‐Tetrachlorphenazins C12H4N2Cl4 wurde roentgenographisch bestimmt. Die Kristalle enviesen sich als omonoklin, Raumgruppe P/c, und ergaben folgende Gitterkonstanten: a0 = 3.85 ± 0.02 Å, b0 = 6. 04 ± 0.02 Å, c0 = 25.33 ω 0.04 Å, β = 91° 46′ ± 15′. Das Molekül ist planar innerhalb der experimentellen Fehlergrenzen; alle intermolekularen Abstände stimmen mit denjenigen aus den van der Waals'schen Radien überein.
Synthesis and properties of fluorine‐containing heterocyclic compounds. I. trifluoromethyl quinolines
Authors: Dey Adrienne Steinacker , Joullié Madeleine M. 
Published: March 2009

AbstractThe condensation of ethyl trifluoroacetoacetate with various aromatic amines, in polyphosphoric acid at 150°, gave substituted 2‐trifluoromethyl‐4‐quinolinols. The structure of these compounds was established from a study of their infrared and ultraviolet spectra and, in some cases, by independent synthesis and cyclization of the intermediate 3‐arylaminocrotonates. The 2‐trifluoromethyl‐4‐quinolinols were converted to 2‐trifluoromethyl‐4‐chloroquinolines which were subjected to hydrogenolysis with Raney nickel to yield 2‐trifluoromethylquinolines and to treatment with an excess of hydrazine to give the corresponding hydrazino derivatives. The diazotization of 2 ‐ trifluoromethyl ‐4‐hydrazinoquinolines yielded azides which were unusually stable. The infrared and ultraviolet spectra of some of the compounds prepared are discussed.
Synthesis and properties of fluorine‐containing heterocyclic compounds. II. trifluoromethyl benzo[h]quinolines, benzo[h]‐1,6‐napthyridines, 1,7‐ and 1,10‐phenanthrolines
Authors: Dey Adrienne Steinacker , Joullié Madeleine M. 
Published: March 2009

AbstractFour heterocyclic rings containing the trifluoromethpl group have been prepared by the reductive, dehalogenation of the corressponding chloro compounds. These were obtained from the hydroxy derivativexs which, in turn, were formed in the condensation of ethyl trifluoroacetoacetate with 1‐naphthylaminc and some substituted aminoquinolines. Spectral data were used to ascertain the position of the hydroxyl group in the hydroxy derivatives. In one case, the position of this group was established by an independent synthesis.
Synthesis of 6, 13‐diazadibenz [a,h] anthracene
Authors: Klemm L. H. , Weisert Annekäte 
Published: March 2009

Abstract6,13‐Diazadibenz[a,h]anthracene (XIa) was synthesized in 15% overall yield for four steps beginning with 2, 5‐diphenyl‐1,4‐benzoquinone. Miscellaneous reactions which led to side products are also described.
Pyridoxine chemistry. VIII. synthesis of 5‐norpyridoxol
Authors: Korytnyk W. , Paul B. 
Published: March 2009

Abstract5‐Norpyridoxol (3,5‐dihydroxy‐4‐hydroxymethyl‐6‐methylpyridine, I) has been synthesized. In contrast to the other two isomeric norpyridoxols (II and III), it proved to be inhibitory to Saccharomyces carlsbergensis. Improved methods of synthesis for some intermediates previously described have been developed.
The preparation of some fluorobenzothiasoles
Authors: Roe Arthur , Tucker William P. 
Published: March 2009

AbstractThe seven possible monofluoro‐2‐phenylbenzothiazoles have been prepared. Each was prepared by potassium hexacyanoferrate(III) oxidation of the appropriately substituted thiobenzanilide. Several were also prepared via a benzyne intermediate through treatment of suitable thiobenzanilides with potassium amide and liquid ammonia.
Quinazolines II. metal hydride reductions
Authors: Smith Richard F. , Briggs Paul C. , Kent Ronald A. , Albright James A. , Walsh Edward J. 
Published: March 2009

AbstractThe following sodium borohydride reductions are reported: 3‐methylquinazolium iodide (I) or its methanolate (II) → Nα, Nα‐dimethyl‐α, 2‐toluenediamine; quinazoline → 3,4‐dihydroquinazoline or 1,2,3,4‐tetrahydroquinazoline (V). The following lithium aluminum hydride reductions are reported: I or II → 3‐methyl‐l,2,3,4‐tetrahydroquinazoline; quinazoline → V + Nα ‐methyl‐α, 2‐toluenediamine (VI); 4 ‐ chloroquinazoline → VI; 2‐chloroquinazoline → VI; 2,4 ‐ dichloroquinazoline → V; 2‐chloro‐4‐phenylquinazo‐ line → 4‐phenyl‐3,4‐dihydroquinazoline; 2‐phenyl‐4‐chloroquinazoline → 2‐phenyl‐3,4‐dihydroquinazoline or Nα ‐ benzyl‐α, 2 ‐ toluenediamine; 4 ‐ methoxyquinazoline → 4‐methoxy‐l,2‐dihydroquinazoline; 4‐phenoxyquinazoline → 4‐phenoxy‐l,2‐dihydroquinazoline; 4‐thiophenoxyquinazoline → VI.
The aldol condensation of aromatic aldehydes with n‐acetyl‐2‐pyrrolidinone: Synthesis of 3‐arylidene‐2‐pyrrolidinones
Authors: Zimmer Hans , Armbruster David C. , Trauth L. J. 
Published: March 2009

AbstractThe synthesis of several 3‐arylidene‐2‐pyrrolidinones (V) by aldol condensation between aromatic aldehydes and N‐acetyl‐2‐pyrrolidinone is reported. The UV‐spectra of structures of type V compounds are discussed and compared with those of the corresponding α ‐arylidene‐γ‐butyrolactones.
Nucleosides XXVIII. 3′‐amino‐3′ ‐deoxyhexopyranosyl nucleosides. Part III. Synthesis of 3′‐amino‐3′‐deoxyhexopyranosyl adenines
Authors: Beránek J. , Friedman H. A. , Watanabe K. A. , Fox J. J. 
Published: March 2009

AbstractTreatment of adenosine with metaperiodate followed by condensation with nitromethane yielded a mixture or 3′‐deoxy‐3′‐nitrohexopyranosyl adenines which were converted to 3′‐amino‐3′‐deoxyhexopyranosyl nucleosides. Separation of this mixture followed by acetylation yielded three crystalline isomeric 9‐(3′‐acetamido‐3′‐deoxy‐2′,4′, 6′‐tri‐O‐acetyl‐β‐D‐hexosyl)adenines which were proved by chemical and n. m. r. studies to be the manno (VII), gulacto (X) and gluco (XIII) derivatives.
The synthesis of various chloroimidazo[4,5‐c]pyridines and related derivatives
Authors: Rousseau Robert J. , Robins Roland K. 
Published: March 2009

AbstractA new and convenient route to the synthesis of 4‐chloroimidazo[4,5‐c]pyridine (IV) has been devised. The preparation of 6‐chloroimidazo[4,5‐c]pyridine (IX) and 4,6‐dichloroimidazo[4, 5‐c]pyridine (XX) has been accomplished for the first time by ring closure of the requisite Chloro‐3.4‐diaminopyridines with ethyl orthoformate and acetic anhydride. Ring closure of 2,4,5‐triaminopyridine (XI) with ethyl orthoformate and acetic anhydride gave 6‐aminoimidazo[4, 5‐c]pyridine (XII). Imidazo[4, 5‐c]pyridine‐4‐thione (XXI has been prepared from 4‐chloroimidazo[4, 5‐c]pyridine.
The synthesis and some reactions of 2‐methyl‐4,5‐pyrimidinediearbonitrile
Authors: Schwan Thomas J. , Tieckelmann Howard 
Published: March 2009

AbstractDiethyl ethoxymethyleneoxalacetate and acetamidine gave 2‐methyl‐4,5‐bis(carbethoxy)‐pyrimidine. The ester was converted to 2‐methyl‐4, 5‐pyrimidinedicarbonitrile which gave 2‐methyl‐4‐methoxy‐5‐pyrimidinecarbonitrile when treated with methanol at room temperature. Attempts to hydrogenate the dinitrile in the presence of nucleophiles led to displacement at C‐4. Attempted hydrogenation of the dinitrile in dimethylformamide gave 2,2′‐dimethyl‐5, 5′‐dicyano‐4, 4′‐bipyrimidine.
Intramolecular diels‐alder cyclization into the thiophene ring
Authors: Kiemm L. H. , Gopinath K. W. 
Published: March 2009

AbstractTrans‐3‐(2‐ and 3‐thienyl)allyl alcohols have been prepared from the corresponding acroleins. The esters of these alcohols with phenylpropiolic acid underwent intramolecular Diels‐Alder reactions to give the substituted dihydrothianaphthene lactones Va and Vb, respectively.
Characterization of Nx,Ny‐Disubstituted adenines by ultraviolet absorption spectra
Authors: Leonard Nelson J. , Carraway Kermit L. , Helgeson John P. 
Published: March 2009

AbstractBy the synthesis of representative Nx,Ny‐dibenzyladenines and determination of their ultraviolet absorption spectra in acidic, basic and neutral solution we have assembled a body of spectral characteristics which makes it possible to distinguish among possible N,N‐disubstituted adenines.
Synthesis of thiophene isosters of benzacridines and dibenzacridines from hydroxy‐ and amino‐thianaphthenes
Authors: Ricci A. , Buu‐Hoi N. P. , Jacquignon P. , Dufour M. 
Published: March 2009

AbstractIn the Ullmann‐Fetvadjian synthesis of dibenzacridines (thermal condensation of a naphthol with a naphthylamine in the presence of paraformaldehyde), 5‐hydroxy‐3‐methyl‐thianaphthene and 3‐phenyl‐5‐aminothianaphthene behave like β‐naphthol and β‐naphthylamine respectively; several analogs of the carcinogenic dibenzacridines, bearing both nitrogen‐ and sulfur‐heteroatoms, have thus been prepared. 3‐Hydroxythianaphthene, which fails to undergo an Ullmann‐Fetvadjian reaction with aniline, readily does so with 4‐aminobiphenyl.
Organic fluoronitrogens. IV. Halo‐Diazirines
Authors: Mitsch Ronald A. , Neuvar Erwin W. , Koshar Robert J. , Dybvig Douglas H. 
Published: March 2009

AbstractThe physical and spectral properties of five previously undisclosed diazirines substituted with electron‐withdrawing groups are described. The halo‐diazirines yield the respective divalent carbon species and nitrogen on pyrolysis. The cyanofluoro‐, fluoro‐methoxy‐ and fluorodifluoramino‐carbenes form the respective cyclopropanes with tetra‐fluoroethylene. The intramolecular reactions of difluoramino‐substituted carbenes are also discussed. The ultraviolet spectra are presented.
Heterocyclic azonia derivatives including new spiro ring systems
Authors: Cossar Bernard C. , Reynolds Delbert D. 
Published: March 2009

AbstractA variety of heterocyclic azonia derivatives have been prepared by reaction of alkoxy‐methylamines with haloalcohols and haloalkylthiols. Many of these represent new heterocyclic azoniaspiro ring systems. Evidence has been presented for structural assignments.
Pyridazines. III. The synthesis of substituted pyridazines
Authors: Castle Raymond N. , Kaji Kenji 
Published: March 2009

AbstractA series of pyridazines and pyridazones have been prepared substituted with alkyl, alkoxyl, halogen, mercapto, substituted mercapto, phenyl, morpholino, piperidino, styryl, substituted styryl and pyridylethenyl groups as potential antitumor agents. The compounds possessing antitumor or tissue culture activity are recorded in Table VI.
The preparation and reduction of 5‐cyano‐3‐indolylketones. Synthesis of 5‐cyanotryptamines
Authors: Degraw Joseph I. , Kennedy Jill G. , Skinner W. A. 
Published: March 2009

AbstractThe acylation of indoles under acidic conditions has been studied. Stannic chloride was shown to be an effective catalyst for the preparation of some 3‐acylindoles, notably 5‐cyano‐3‐indolylketones. The various 5‐cyano ‐3 ‐ indolylketones were reduced with sodium borohydride to yield either the 5‐cyano‐3‐carbinols or 5‐cyano‐3‐alkylindoles. 5‐Cyanotryptamines were obtained by reduction of appropriate α‐dialkylamino and α‐azidoketones. A cleavage reaction of the carbinols involving loss of the 3‐side chain to yield 5‐cyanoindole is also described.
The action of organolithium compounds on phthalazine and I (2H)‐phthalazinone
Authors: Hisrch A. , Orphanos D. G. 
Published: March 2009

AbstractPhthalazine and 1(2H)‐phthalazinone undergo 1,2‐addition of organolithium compounds to C = N to give, following hydrolysis, 1 ‐ substituted ‐ 1,2 ‐ dihydrophthalazines and 4‐substituted‐3,4‐dihydro‐1(2H)‐phthalazinones respectively. These dihydro‐derivatives may be easily autoxidized to the corresponding 1‐substituted phthalazines and 4‐substituted‐1(2H)‐phthalazinones.
Synthetic furocoumarins. Xanthotoxin and methylxanthotoxins
Authors: De Souza Noël J. , Nayak P. Vathsala , Secco Ella 
Published: March 2009

AbstractThe synthesis of 4‐methylxanthotoxin (X), 4,5′‐dimethylxanthotoxin (XXIV) and the hitherto unknown 5′‐methylxanthotoxin (XXIII) are described, using 6‐allyl‐7‐hydroxy‐8‐methoxycoumarin (XV) and its 4‐methyl derivative (XVII) as intermediates.
Synthesis of alkylaminoethanethiolsulfuric acids substituted with heterocyclic moieties
Authors: Singerman Gary M. , Kimura Ryuichi , Riebsomer J. L. , Castle Raymond N. 
Published: March 2009

AbstractSeveral alkylaminoethanethiolsulfurie acids substituted with heterocyclic moieties have been synthesized to determine their effectiveness as radiation protection agents. These compounds are represented by the structure R(CH2)3NH(CH2)2S2O3H, where R is 8‐quinoly‐oxy (V), 8‐quinaldyloxy (IX), 5‐quinolyloxy (XII), 4‐pyridyl (XVI), and 4‐pyridylmethyl (XXIII). The diheterocyclic‐substituted compound, 2‐[bis‐(2‐phenyl‐1, 2, 3, 2H‐triazol‐4‐ylmethyl)amino]ethanethiolsulfuric acid (XIV) was also synthesized.
The thermal decomposition of 3‐azido‐4‐benzylideneamino‐s‐triazoles
Authors: Takimoto H. H. , Denault G. C. , Hotta S. 
Published: March 2009

AbstractThe synthesis and thermal decomposition of a series of 3‐azido‐4‐benzylideneamino‐s‐triazoles are described. The decompositions resulted in a loss of nitrogen and intra‐molecular cyclization at the carbon atom of the azomethine linkage to produce 1H‐2‐aryl‐s‐triazolo‐[3,2‐c]‐s‐triazoles.
Synthesis of vitamin B6derivatives I. Preparation of some isopyridoxamine derivatives from isopyridoxal
Authors: Brooks Houston G. , Laakso J. W. , Metzler David E. 
Published: March 2009

AbstractImproved syntheses of isopyridoxal and isopyridoxamine are described. New 5‐N‐substituted isopyridoxamine derivatives resulting from condensation followed by reduction of the carbonyl group of isopropylideneisopyridoxal with aniline, 2‐aminothiazole and benzylamine are also reported.
Mass spectrometry of 10‐chloro‐5, 10‐dihydrophenarsazine (adamsite) and 10‐methyl‐5, 10‐dihydrophenarsazine
Authors: Buu‐Hoi N. P. , Mangane M. , Jacquignon P. 
Published: March 2009

AbstractThe mass spectrograms of 10‐chloro‐ and 10‐methyl‐5,10‐dihydrophenarsazine have been determined. These spectrograms show the following main characteristics of fragmentation behavior for these heterocycles: (a) a relative stability, in both compounds, of the arsenic atom within the heterocyclic framework; (b) an exceptionally facile splitting of the As‐Cl bond, contrasting with the behavior of the As‐CH3 bond; and (c) an easy formation of the phenarsazine species from 10‐chloro‐5,10‐dihydrophenarsazine.
A new synthesis of alkyl and aryl 2‐aminoimidazoles
Authors: Lancini Gian Carlo , Lazzari Ettore 
Published: March 2009

AbstractThe condensation of cyanamide with α‐aminocarbonyl compounds has been studied as a method of synthesizing alkyl and aryl 2‐aminoimidazoles. Starting fromN‐alkylamino‐aldehydes, 1,5‐dialkyl‐2‐aminoimidazoles have been prepared. Starting from suitable aminoketones a variety of monosubstituted and disubstituted derivatives were obtained.
The mass spectra of oxygen heterocycles (III) . An examination of simple lignans
Authors: Pelter Andrew , Stainton A. P. , Barber M. 
Published: March 2009

AbstractThe mass spectra of some simple lignans containing the tetrahydrofuran nucleus have been examined. The fragmentation patterns of various types have been defined and shown not to be sensitive to the stereochemistry of the substituents. Positional isomers however give very different mass spectra.
The synthesis of 1‐(2‐dialkylaminoethyl)‐5 (and 6)‐methoxy‐2‐methyl (and H)‐benzimidazoles
Authors: Burch Homer A. , Herbst Robert M. 
Published: March 2009

AbstractThe syntheses of twenty 1‐(2‐dialkylaminoethyl)‐5 (and 6)‐methoxy‐2‐methyl (and H)‐benzimidazoles in which the dialkylamino groups are dimethylamino, diethylamino, pyrrolidino, piperidino and morpholino, are presented. These compounds failed to show any significant biological activity.
Morphanthridines III. 6‐Basic substituted morphanthridines
Authors: Drukker Alexander E. , Judd Claude I. , Dusterhoft Donald D. 
Published: March 2009

AbstractThe reaction of hydrazines and amines with 6‐chloromorphanthridine was investigated. Grignard coupling of aminoalkyl halides with 6‐chloromorphanthridine afforded 6‐amino‐alkylmorphanthridines. Cyclization of 6‐(2‐chloroethylamino)morphanthridine yielded the new ring system 5′H‐imidazo[5, 6‐a]dibenz[b, ejazepine, which was aminoalkylated by generation of the 11‐position anion with butyllithium, followed by treatment with a tertiary aminoalkyl halide.
Electron‐bombardment and pyrolysis of meso‐ and dl‐hydrobenzoin cyclic sulfites
Authors: Pritchard J. G. , Funke Phillip T. 
Published: March 2009

AbstractOnly a minor yield of sulfur dioxide positive ions is eliminated from the meso‐ and dl‐hydrobenzoin cyclic sulfite molecules under electron bombardment. Among the principal fragmentation products for both sulfites are very similar yields of ions with m/e 154 and 126, which contain sulfur most probably attached to a phenyl ring. Positive ions apparently corresponding to those of diphenylacetaldehyde, desoxybenzoin, and stilbene are minor products of the positive‐ion fragmentation process of the sulfites. These three compounds along with sulfur dioxide are the products of the pyrolysis of the sulfites at 240‐250°. The principal product from the meso‐sulfite is desoxybenzoin, and from the dl‐sulfite it is diphenylacetaldehyde. Mechanistic details are discussed.
The chemistry of heterocycles. IV. 2H‐pyrido[4,3‐e]‐1,3‐oxazine‐2,4(3H)‐dione, its precursors and some 3‐substituted derivatives.
Authors: Crum J. D. , Fuchsman C. H. 
Published: March 2009

AbstractThe preparation of 2H‐pyrido[4, 3‐e]‐1, 3‐oxazine‐2, 4(3H)‐dione (II) and the anisoyl, benzoyl, 4‐chlorobenzoyl, trans‐cinnamoyl, 3, 5‐dinitrobenzoyl, 2‐furoyl, and 2‐naphthoyl derivatives substituted at position 3 of II together with their infrared and ultraviolet spectra are described. The 3‐substituted 2 and 4‐(2‐pyridylethyl) and hydroxymethyl derivatives of quinolinimide and cinchomeronimide were also prepared and their spectra recorded.
The synthesis of substituted 8‐quinolinols
Authors: Kolobielski Marjan 
Published: March 2009

Abstract2‐Isopropyl‐8‐quinolinol was prepared by alkylation of 8‐methoxyquinoline followed by demethylation. The 7‐isopropyl‐8‐quinolinol was prepared in three steps from o‐isopropylphenol. The reaction of 5‐chloromethyl‐8‐quinolinol hydrochloride with alcohols, amines, ethylene glycols and ether‐alcohols gave the corresponding 5‐substituted derivatives of 8‐quinolinol.
Nuclear magnetic resonance of benzobisheterocyclic compounds
Authors: Grandolini Giuliano , Ricci Adolfo , Martani Alfio , Delle Monache Franco 
Published: March 2009

AbstractThe nuclear magnetic resonance spectra of forty‐nine benzobisheterocyclic compounds, containing various heterocycles, were determined. The observed spectral data made possible the elucidation of the structure and also clarified the influences of the heterocyclic substituents and of heterocyclic rings on chemical shift values of the aromatic protons.
Aldol and claisen condensations with 1‐(3,4‐dichlorophenyl)‐2‐pyrrolidinone
Authors: Seidel Michael C. , Cook Richard S. 
Published: March 2009

Abstract1‐(3,4‐Dichlorophenyl)‐2‐pyrrolidinone (I) has been condensed at the 3‐position with a series of aldehydes, ketones and esters.
Synthesis of 6‐substituted pyrimidines by the wittig reaction. III . Via 2‐amino‐4‐hydroxy‐5‐phenylbutyl‐6‐pyrimidylmethyl triphenyl phosphonium bromide
Authors: Baker B. R. , Jordaan Johannes H. 
Published: March 2009

Abstract2‐Amino‐6‐bromomethyl‐5‐phenylbutyl‐4‐pyrimidinol (IV) smoothly alkylated triphenyl phosphine, resulting in a 95% yield of the phosphonium salt (V). This Wittig reagent (V) readily condensed with p‐nitrobenzaldehyde, p‐nitrocinnamaldehyde, or cinnamalde‐hyde in N,N‐dimethylformamide to give the 6‐(p‐nitrostyryl) (X), 6‐(p‐nitrophenyl‐1,3‐butadien‐1‐yl) (VIH), and 6‐(phenyl‐1,3‐butadien‐1‐yl) (IX) pyrimidinols in 72, 67 and 44% yields, respectively. Catalytic reduction of VIII and IX afforded the corresponding 6‐(p‐aminophenylethyl) (XII) and 6‐(p‐aminophenylbutyl) (XI) 4‐pyrimidinols.
Synthesis of 1,3,4‐thiadiazoles containing the trifluoromethyl group
Authors: Lalezari I. , Sharghi N. 
Published: March 2009

AbstractThe following compounds have been synthesized: 2‐Amino‐5‐trifluoromethyl‐1,3,4‐thiadiazole; N‐(5‐trifluoromethyl ‐ 1,3,4‐thiadizol‐2‐yl)benzenesulfonamide; N1‐(5‐trifluoromethyl‐1,3,4‐thiadiazol‐2‐yl)sulfanilamide, its N4‐acetyl, N4‐succinyl, and N4‐pathalyl derivatives; o ‐ m ‐ and p‐trifluoromethylbenzoylthiosemicarbazide, their corresponding 2‐amino‐1,3,4‐thiadiazoles, their corresponding sulfanilamides, their N4‐acetyl, N4‐succinyl and N4‐phthalyl derivatives; 3‐o‐trifluoromethylphenyl‐4H‐1,2,4‐triazole‐5‐thiol. Preliminary in‐vitro assays show that synthesized sulfanilamide derivatives have antibacterial activity against Staphylococcus aureus.
New reactions of pyrroles. I. pyridylethylpyrroles
Authors: Archibald John L. 
Published: March 2009

AbstractPyrroles with unsubstituted 2‐ and/or 5‐positions are found to react with 4‐vinyl‐pyridine, giving hitherto unreported 2‐ and 2,5‐di‐ pyridylethylpyrroles. Pyrrole‐2‐carboxylic acids can also react to give the same products by displacement of the carboxyl group. Pyridylethylation at an available 3‐ and/or 4‐position was not observed. Catalytic reductions and alkylations of the resulting piperidylethylpyrroles are also reported.
Deuterium exchange of 4‐pyrimidones and 4‐pyrimidthiones
Authors: Wright George E. , Bauer Ludwig , Bell Charles L. 
Published: March 2009

AbstractThe hydrogen‐deuterium exchange of H‐2 in 4‐pyrimidone, a number of 1‐ and 3‐alkyl‐4‐pyrimidones and several of their thione analogs in deuterium oxide at moderate temperatures is reported. This reaction is apparently not susceptible to acid or base catalysis. Cations of the 4‐pyrimidones were found not to exchange H‐2 at all in acid media. Catalytic amounts of bases do not alter the exchange rates whereas more concentrated alkali decompose the pyrimidone. However, 1,4(3,4)‐dihydro‐1,3‐dimethyl‐4‐oxopyrimidinium iodide (and its 6‐methyl analog) exchange H‐2 quite rapidly in neutral deuterium oxide, almost instantly when triethylamine is added as a catalyst, and very slowly in dilute solutions of deuterium chloride in deuterium oxide. Mechanisms are proposed to account for these phenomena.
4‐Amino‐2‐oxazolidinones
Authors: Strumza Jacob , Ben‐Ishai Dov 
Published: March 2009

AbstractThermal cyclization of β‐haloalkylidenebisbenzylcarbamates (III) and subsequent hydro‐genolysis of the intermediate 4‐carbobenzoxyamino‐2‐oxazolidinones (IV) afford 4‐amino‐2‐oxazolidinones (V). Some of the chemical properties of the aminooxazolidinones are also described.
Synthesis of isatin‐N‐mannich bases
Authors: Varma Rajendra S. , Nobles W. Lewis 
Published: March 2009

AbstractThe synthesis of a series of isatin‐N‐Mannich bases derived from isatin, 5‐methyl and 5‐bromoisatins as the active hydrogen component and dimethylamine, diethylamine, morpholine, piperidine, N‐ethylcyclohexylamine, 3‐azabicyclo[3.2.2]nonane and 3‐aza‐bicyclo[3.2.1]octane as the secondary amine moiety is described. These compounds are to be screened for their pharmacological properties.
N‐Heteroaralkyl substituted α‐amidinium thiolsulfates
Authors: Parulkar Anilkumar P. , Bauer Ludwig 
Published: March 2009

AbstractThe syntheses of a number of N‐substituted α‐amidinium thiolsulfates, CH2(S2O3−)‐C(=NH2+)NH(CH2)nR are described, where n was varied from 1 to 3 and R represents such heteroaryl groups as 2‐furyl, 2‐thienyl, 3‐indolyl and 2‐, 3‐ and 4‐pyridyl. The preparation of S‐(2‐imidazolinemethyl)thiolsulfuric acid, as an example of an N, N'‐disubstituted α‐amidinium thiolsulfate, is also reported.
Heterocyclic steroids. X. 2‐Aza‐4‐oxa‐steroid analogs
Authors: Piatak D. M. , Caspi E. 
Published: March 2009

AbstractTwo 2‐aza‐4‐oxa steroids have been synthesized from acid Ia. In addition the Beckmann rearrangement of the C‐1 amide Ij has been explored.
Synthesis of some N‐methylated pteridines related to 7,8‐dihydroxanthopterin
Authors: Zondler Helmut , Forrest H. S. , Lagowski J. M. 
Published: March 2009

AbstractSeven methylated pteridines have been synthesized by condensation of a 4‐chloro‐5‐nitropyrimidine with a β‐ketoamine (or a blocked derivative), reduction of the nitro group, and subsequent ring closure. This scheme provides a new route to dihydroxanthopterin. Several cases are reported, however, in the uracil series where ring closure could not be effected.