bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Flexible Total Synthesis of Biphenomycin B.
Authors: Waldmann Herbert , He Yu‐Peng , Tan Hao , Arve Lars , Arndt Hans‐Dieter 
Published: March 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Palladium‐Mediated Cascade Cyclization Approach to the CDE Cores of Rubriflordilactone A and Lancifodilactone G.
Authors: Cordonnier Marie‐Caroline A. , Kan S. B. Jennifer , Anderson Edward A. 
Published: March 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Modular and Organocatalytic Approach to γ‐Butyrolactone Autoregulators from Streptomycetes.
Authors: Elsner Petteri , Jiang Hao , Nielsen Johanne B. , Pasi Filippo , Joergensen Karl Anker 
Published: March 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Cathepsin B Inhibitory Activities of Three New Phthalate Derivatives Isolated from Seahorse, Hippocampus Kuda Bleeler,
Authors: Li Yong , Qian Zhong‐Ji , Kim Se‐Kwon 
Published: March 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Langmuir—Blodgettry of Nanocrystals and Nanowires
Authors: Tao Andrea R. , Huang Jiaxing , Yang Peidong 
Published: March 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: New Aspects of Carrier Multiplication in Semiconductor Nanocrystals
Authors: McGuire John A. , Joo Jin , Pietryga Jeffrey M. , Schaller Richard D. , Klimov Victor I. 
Published: March 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Fullerenes as a New Type of Ligands for Transition Metals
Authors: Sokolov V. I. 
Published: March 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: DTBS Effect: The Unique Sterically Driven Director for α‐Galactosylation
Authors: Imamura Akihiro , Ando Hiromune , Ishida Hideharu , Kiso Makoto 
Published: March 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Recent Advances in Lewis Base‐Catalyzed, Stereoselective, Tandem Aldol β‐ and γ‐Lactonizations
Authors: Purohit Vikram C. , Matla Andrea S. , Romo Daniel 
Published: March 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Transition Metal Mediated Strategies Toward Lignans and Related Natural Compounds
Authors: Bouyssi D. , Monteiro N. , Balme G. 
Published: March 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Connecting Heterocycles via a Catalyzed Lithiation
Authors: Foubelo Francisco , Garcia Daniel , Moreno Benjamin , Yus Miguel 
Published: March 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: ATP‐Noncompetitive Inhibitors of CDK—Cyclin Complexes
Authors: Orzaez Mar , Gortat Anna , Mondragon Laura , Bachs Oriol , Perez‐Paya Enrique 
Published: March 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Cyclodextrins as Drug Carrier Molecule: A Review
Authors: Arun Rasheed , Ashok Kumar C. K. , Sravanthi V. V. N. S. S. 
Published: March 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Exceptional Selectivity in Cyclopropanation Reactions Catalyzed by Chiral Cobalt(II)—Porphyrin Catalysts
Authors: Doyle Michael P. 
Published: March 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Monosaccharides and Analogues. Part 3. Monosaccharides from Simple Achiral Unsaturated Compounds
Authors: Robina Inmaculada , Vogel Pierre 
Published: March 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Glycosyl Oxygen Compounds (Di‐ and Oligosaccharides)
Authors: Demchenko A. V. , De Meo C. 
Published: March 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: MicroRNAs Repress Mainly Through mRNA Decay
Authors: Esslinger Stephanie , Foerstemann Klaus 
Published: March 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Biochemistry of Drug Metabolism — An Introduction. Part 6. Inter‐Individual Factors Affecting Drug Metabolism
Authors: Kraemer Stefanie D. , Testa Bernard 
Published: March 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Nanomedicine—Challenge and Perspectives
Authors: Riehemann Kristina , Schneider Stefan W. , Luger Thomas A. , Godin Biana , Ferrari Mauro , Fuchs Harald 
Published: March 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Fine Tuning the N‐Terminal Residue Excision with Methionine Analogues
Authors: Wiltschi Birgit , Merkel Lars , Budisa Nediljko 
Published: March 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Dynamic Nuclear Polarization: New Experimental and Methodology Approaches and Applications in Physics, Chemistry, Biology and Medicine
Authors: Prisner Thomas , Kockenberger Walter 
Published: March 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Kinesin‐5 in Drosophila embryo mitosis: Sliding filament or spindle matrix mechanism?
Authors: Scholey Jonathan M. 
Published: March 2009

AbstractThe Drosophila syncytial embryo uses multiple astral mitotic spindles that are specialized for rapid mitosis. The homotetrameric kinesin‐5, KLP61F contributes to various aspects of mitosis in this system, all of which are consistent with it exerting outward forces on spindle poles. In principle, kinesin‐5 could accomplish this by (i) sliding microtubules (MTs), minus end leading, relative to a static spindle matrix or (ii) crosslinking and sliding apart adjacent pairs of antiparallel interpolar (ip) MTs. Here, I critically review data on the biochemistry of purified KLP61F, its localization and dynamic properties within spindles, and quantitative modeling of KLP61F function. While a matrix‐based mechanism may operate in some systems, the work tends to support the latter “sliding filament” mechanism for KLP61F action in Drosophila embryo spindles. Cell Motil. Cytoskeleton 2009. © 2009 Wiley‐Liss, Inc.
Synthesis, Modelling, and Antimitotic Properties of Tricyclic Systems Characterised by a 2‐(5‐Phenyl‐1H‐pyrrol‐3‐yl)‐1,3,4‐oxadiazole Moiety
Authors: Pinna Gérard A. , Murineddu Gabriele , Murruzzu Caterina , Zuco Valentina , Zunino Franco , Cappelletti Graziella , Artali Roberto , Cignarella Giorgio , Solano Lucrezia , Villa Stefania 
Published: March 2009

AbstractAntitumour activity was observed in a series of tricyclic compounds characterised by a 2‐(1H‐pyrrol‐3‐yl)‐1,3,4‐oxadiazole moiety with various substitutions. Their synthesis and antiproliferative activity toward a panel of human tumour cell lines is described. The most interesting compounds 1 c and 4 c were selected for further evaluation to elucidate their possible mechanism of action.magnified imageInteresting antitumour activity was observed in a series of tricyclic compounds characterised by the presence of a 2‐(1H‐pyrrol‐3‐yl)‐1,3,4‐oxadiazole moiety that is variously substituted. Their synthesis and antiproliferative activity toward a panel of human tumour cell lines is described. The two most interesting compounds were selected for further evaluation to elucidate their possible mechanism of action. Analysis of cell cycle, tubulin polymerisation, modulation of mitotic markers of the M phase, and apoptosis showed that antimitotic activity is the primary mechanism of the cytotoxic effects of these compounds. Experiments performed on isolated tubulin confirmed that the compounds act by inducing tubulin polymerisation, like taxanes. The binding model against tubulin was also examined by molecular modelling and docking. The results support the proposed binding model, which is able to explain the activity of the oxadiazole derivatives on the basis of their docking energy.
Copolymerization of Divinylsilyl‐11‐silicotungstic Acid with Butyl Acrylate and Hexanediol Diacrylate: Synthesis of a Highly Proton‐Conductive Membrane for Fuel‐Cell Applications
Authors: Horan James L. , Genupur Anitha , Ren Hui , Sikora Benjamin J. , Kuo Mei‐Chen , Meng Fanqin , Dec Steven F. , Haugen Gregory M. , Yandrasits Michael A. , Hamrock Steven J. , Frey Matthew H. , Herring Andrew M. 
Published: March 2009

AbstractHighly conducive to high conductivity: Polyoxometalates were incorporated in the backbone of a hydrocarbon polymer to produce proton‐conducting films. These first‐generation materials contain large, dispersed clusters of polyoxometalates. Although the morphology of these films is not yet optimal, they already demonstrate practical proton conductivities and proton diffusion within the clusters appears to be very high.magnified image
Kinetics of CHO AL mutant expression after treatment with γ radiation, EMS, and asbestos
Authors: Keysar Stephen B. , Fox Michael H. 
Published: March 2009

AbstractThe flow cytometry mutation assay (FCMA) uses hybrid CHO AL cells to measure mutations of the cd59 gene located on human chromosome 11 by the absence of fluorochrome‐conjugated antibody binding to the CD59 surface antigen. Mutant expression peaks between 6 and 12 days, then decreases to a stable plateau, instead of a constant mutant fraction obtained by clonogenic assays. To evaluate this variable mutant expression time, cells were treated with radiation, EMS or asbestos and cell proliferation and survival were measured at times leading up to peak mutant expression. Potential doubling time (Tpot) values increased by at least 75% for each agent by 3 h after treatment but returned to control levels after only 3 days. Survival returned to 90% of control within a week, close to the peak expression day for all three agents. The survival of CD59− cells sorted on the peak day of expression was roughly half that of CD59+ cells. Cloned EMS‐treated CD59− cells had a doubling time of 16.7 vs. 14.1 h for CD59+ cells. Triple mutants (CD59−/CD44−/CD90−) were preferentially lost from the population over time, while the proportion of CD59−/CD90− mutants increased. In conclusion, the peak day of mutant expression occurs only when cells recover from the toxic effects of the mutagen. A fraction of cells originally quantified as mutants are lost over time due to lethal deletions and slower growth. © 2009 International Society for Advancement of Cytometry
Human self‐protein CD8+ T‐cell epitopes are both positively and negatively selected
Authors: Almani Michal , Raffaeli Shai , Vider‐Shalit Tal , Tsaban Lea , Fishbain Vered , Louzoun Yoram 
Published: March 2009

AbstractThe cellular immune system recognizes self‐epitopes in the context of MHC‐I molecules. The immunological general view presumes that these self‐epitopes are just a background, both positively and negatively selecting T cells. We here estimate the number of epitopes in each human protein for many frequent HLA alleles, and a score representing over or under presentation of epitopes on these proteins. We further show that there is a clear selection for the presentation of specific self‐protein types. Proteins presenting many epitopes include, for example, autoimmune regulator (AIRE) upregulated tissue‐specific antigens, immune system receptors and proteins with a high expression level. On the other hand, proteins that may be considered less “useful” for the immune system, such as low expression level proteins, are under‐presented. We combine our epitope estimate with single nucleotide polymorphism (SNP) measures to show that this selection can be directly observed through the fraction of non‐synonymous SNP (replacement fraction), which is significantly higher inside epitopes than outside.
Negative feedback regulation of IL‐32 production by iNOS activation in response to dsRNA or influenza virus infection
Authors: Li Wei , Yang Fang , Liu Yan , Gong Rui , Liu Li , Feng Yong , Hu Pan , Sun Wei , Hao Qian , Kang Lei , Wu Jianguo , Zhu Ying 
Published: March 2009

AbstractiNOS plays an important role in mediating inflammation. In this study, we found that iNOS‐derived NO was increased 2.4‐fold in the serum samples of 101 patients infected with influenza A virus in comparison with samples of 105 healthy individuals. In A549 human lung epithelial cells, infection with influenza A virus or stimulation with poly(I:C)+IFN‐γ resulted in increased mRNA and protein levels of both IL‐32 and iNOS, with subsequent release of NO. Over‐expression of IL‐32 resulted in upregulated iNOS expression with subsequent NO production. Knock down of IL‐32 by IL‐32‐specific siRNA resulted in the inhibition of dsRNA‐induced expression of iNOS and NO release, indicating that IL‐32 is an upstream regulatory factor of dsRNA‐triggered iNOS production. Surprisingly, over‐expression of iNOS resulted in the reduction of IL‐32 expression, and suppression of iNOS by the selective iNOS inhibitor S‐methylisothiourea sulfate stimulated IL‐32 expression, indicating that a negative feedback mechanism operates between the iNOS/NO and IL‐32 systems. These findings suggest that influenza A virus infection activates IL‐32 and iNOS expression by a heretofore unrecognized complex mechanism, in which the two pro‐inflammatory factors regulate each other, involving positive and negative feedback regulatory loops.
Synergy‐inducing chemokines enhance CCR2 ligand activities on monocytes
Authors: Kuscher Katrin , Danelon Gabriela , Paoletti Samantha , Stefano Luisa , Schiraldi Milena , Petkovic Vibor , Locati Massimo , Gerber Basil O. , Uguccioni Mariagrazia 
Published: March 2009

AbstractThe migration of monocytes to sites of inflammation is largely determined by their response to chemokines. Although the chemokine specificities and expression patterns of chemokine receptors are well defined, it is still a matter of debate how cells integrate the messages provided by different chemokines that are concomitantly produced in physiological or pathological situations in vivo. We present evidence for one regulatory mechanism of human monocyte trafficking. Monocytes can integrate stimuli provided by inflammatory chemokines in the presence of homeostatic chemokines. In particular, migration and cell responses could occur at much lower concentrations of the CCR2 agonists, in the presence of chemokines (CCL19 and CCL21) that per se do not act on monocytes. Binding studies on CCR2+ cells showed that CCL19 and CCL21 do not compete with the CCR2 agonist CCL2. Furthermore, the presence of CCL19 or CCL21 could influence the degradation of CCL2 and CCL7 on cells expressing the decoy receptor D6. These findings disclose a new scenario to further comprehend the complexity of chemokine‐based monocyte trafficking in a vast variety of human inflammatory disorders.
Efficient Asymmetric Synthesis of Planar‐Chiral Bisferrocenes
Authors: Enders Dieter , Jonas Eric Alexander , Klumpen Thomas 
Published: March 2009

AbstractSAMP auxiliary‐derived monosubstituted diferrocenyl ketones have been subjected to ortho‐metalation/functionalization reactions to prepare chiral disubstituted bisferrocenes. The reactions proceeded in low to moderate yields (20–54 %) and excellent stereoselectivities (97 – ≥ 99 % ee, ≥ 96 % de), however low regio‐selectivities were obtained in several cases. Monosubstituted bisferrocenes, containing only a planar‐chiral element, were excellent substrates in the same ortho‐metalation/functionalization reaction affording disubstituted bisferrocenes in moderate to excellent yields (39–99 %) and generally excellent levels of asymmetric induction (≥96 % de) with complete regiocontrol. The synthesis of related methylene‐bridged mono‐ and di‐substituted diferrocenyl ligands containing N‐, O‐, P‐ and/or S‐donor atoms is also described.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Sensitivity of runoff and soil erosion to climate change in two Mediterranean watersheds. Part I: model parameterization and evaluation
Authors: Nunes J. P. , Seixas J. , Keizer J. J. , Ferreira A. J. D. 
Published: March 2009

AbstractClimate change is expected to effect storm runoff and erosion processes in Mediterranean watersheds at multiple spatial scales. Models are typically applied to estimate these impacts; however, the scarcity of spatially distributed data for parameterization, calibration and validation often prevents application of these models, particularly for larger catchments. This report, the first part of a two‐part article, presents an application and evaluation of the MEFIDIS model for two Mediterranean meso‐scale watersheds (115 and 290 km2) in a data‐scarce environment. A multi‐scale assessment method was used that combines quantitative validation and qualitative evaluation, consisting of three steps: (1) calibration at the small (field) scale using results from rainfall simulation experiments; (2) calibration and validation for catchment‐scale results while changing catchment‐scale parameters only (channel roughness and a parameter controlling the distribution of saturated areas); and (3) qualitative evaluation of within‐watershed erosion processes using empirical estimates of sediment delivery ratio and gully location. The results indicate that calibrating MEFIDIS at the field scale can provide reasonable results for catchment runoff and sediment export and for within‐watershed erosion processes. Copyright © 2009 John Wiley & Sons, Ltd.
Metallation and reaction of 4,5‐dicyanoimidazoles with alkyllithium reagents
Authors: Apen Paul G. , Rasmussen Paul G. 
Published: March 2009

AbstractThe conditions required for selective lithiation at the 2‐position of 4,5‐dicyanoimidazoles are described in detail. The course of the reaction of alkyllithium reagents with 4,5‐dicyanoimidazoles depends on the temperature, the number of equivalents of alkyllithium and whether the 1‐nitrogen is protected. Under certain circumstances, the alkyllithium reagent adds to one of the cyano groups giving cyanoimidazole ketones.
Studies on pyridonecarboxylic acids . 2. Synthesis and antibacterial activity of 8‐substituted‐7‐fluoro‐5‐oxo‐5H‐thiazolo[3,2‐a]quinoline‐4‐carboxylic acids
Authors: Segawa Jun , Kitano Masahiko , Kazuno Kenji , Tsuda Masami , Shirahase Ichiro , Ozaki Masakuni , Matsuda Masato , Kise Masahiro 
Published: March 2009

AbstractA series of 8‐substituted‐7‐fluoro‐5‐oxo‐5H‐thiazolo[3,2‐a]quinoline‐4‐carboxylic acids was prepared and evaluated for antibacterial activity. These compounds were synthesized from ethyl 2‐mercaptoquinoline‐3‐carboxylates 17 which were obtained from anilines 11 by a route involving an intramolecular cyclization reaction.