bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Marrow Penetration on Bone Augmentation Within a Titanium Cap in Rabbit Calvarium
Authors: Min Seiko , Sato Shuichi , Murai Masakazu , Okuno Kenji , Fujisaki Yoshiaki , Yamada Yutaka , Ito Koichi 
Published: October 2007

Background: Some studies have advocated marrow penetration in guided bone augmentation (GBA), whereas others have shown that bone can be generated without marrow penetration. This study examined the effect of marrow penetration and the optimal rate of penetration.Methods: In 10 rabbits, the calvarium was exposed, and circular grooves were prepared bilaterally. Within the circular groove, the external cortical surface of the skull was perforated mechanically using a number 4 round bur (experimental site), whereas the bone surface on the other groove (control site) was left intact. The rate of penetration was standardized as 28% for the experimental site and 0% for the control site. Subsequently, two standardized titanium caps with an inner diameter of 8 mm and an inner height of 4 mm were anchored in the prepared grooves. Five rabbits each were euthanized at 1 and 3 months, and the percent area of newly generated tissue and mineralized bone in the newly generated tissue under the titanium cap was determined.Results: Histomorphometric analysis showed significantly increased bone neogenesis in the experimental site at 3 months. The percent area of mineralized bone in the newly generated tissue was consistently higher in the experimental site at 3 months.Conclusion: In the rabbit calvarium using a titanium cap GBA model, bone augmentation was significantly greater with marrow penetration than without penetration.
Gingival Crevicular Fluid Levels of Neopterin in Healthy Subjects and in Patients With Different Periodontal Diseases
Authors: Pradeep A.R. , Kumar Magesh S. , Ramachandraprasad M.V. , Shikha Chowdhry 
Published: October 2007

Background: Neopterin, a metabolite of guanosine, belongs to the class of chemical compounds known as pteridines and is an early and valuable marker of cellular immunity. Recently, it was shown to be associated with the initiation and progression of periodontal disease. The aim of the present study was to assess the relationship between clinical parameters and concentrations of neopterin within gingival crevicular fluid (GCF) from inflamed gingiva and periodontitis sites before and after the treatment of periodontitis.Methods: Sixty age (35 to 65 years)‐ and gender‐matched (30 males and 30 females) subjects were recruited and divided into the following four groups of 15 subjects each based on gingival index, Ramfjord periodontal disease index, clinical attachment loss (CAL), and radiographic parameters (bone loss): healthy (group 1), gingivitis (group 2), mild periodontitis (group 3), and moderate to severe periodontitis (group 4). A fifth group consisted of the 15 subjects from group 4, 6 to 8 weeks after treatment (scaling and root planing). GCF was collected from each patient, and the neopterin levels were determined by enzyme immunoassay. Results were analyzed statistically.Results: The mean concentration of neopterin in GCF was the highest in group 4 (51 nmol/l) and the lowest in group 1 (1.36 nmol/l). The mean neopterin concentrations in group 2 (9.69 nmol/l) and group 3 (16.58 nmol/l) fell between the highest and lowest values. This suggested a positive correlation between CAL and GCF neopterin concentrations. Neopterin levels in group 4 decreased to 1.77 nmol/l after treatment (group 5).Conclusions: Neopterin increased in parallel with the severity of inflammatory disease. Its levels in GCF may be potentially useful as an indicator of periodontal inflammation and the host response.
Effects of TGF‐β1, PDGF‐BB, and IGF‐1 on the Rate of Proliferation and Adhesion of a Periodontal Ligament Cell Lineage In Vitro
Authors: Sant'Ana Adriana C.P. , Marques Márcia M. , Barroso Emildre C. , Passanezi Euloir , de Rezende Maria Lúcia Rubo 
Published: October 2007

Background: Considering the role of growth factors in periodontal regeneration, the aim of this study was to evaluate the influence of platelet‐derived growth factor (PDGF)‐BB, insulin‐like growth factor (IGF)‐1, and transforming growth factor‐beta 1(TGF‐β1), alone or in combination, on the rate of proliferation and adhesion of periodontal ligament (PDL) cells in vitro.Methods: After establishment and characterization of a primary culture of PDL cells, 72 culture dishes were plated with 103 cells distributed among four test groups and a control group. Test groups had PDGF‐BB, TGF‐β1, IGF‐1, or a combination of all three added to the culture medium, whereas the control group received no growth factor. The samples were counted in triplicate 1, 3, 5, and 7 days after seeding. For the adhesion assay, 14 patients provided 30 root fragments distributed among 10 groups: scaling and root planing (SRP), SRP + growth factors, SRP + citric acid plus tetracycline (CA+T), and SRP + (CA+T) + growth factors. The data were evaluated statistically by analysis of variance complemented by Tukey, Dunnett, and Student‐Newman‐Keuels methods.Results: Maximum rates of proliferation were observed at day 3 for all groups. TGF‐β1 induced a 344.17% ± 58.80% increased proliferation rate over control (P <0.05), followed by the combination (277.5% ± 29.38%), PDGF‐BB (238.79% ± 5.79%), and IGF‐1 (233.16% ± 19.19%). Groups treated by (CA+T) showed increased numbers of cells attached to root fragments, especially SRP + (CA+T) + combination (13.25 ± 1.79), with significant differences (P <0.05) from groups treated only by SRP.Conclusion: This combination of growth factors stimulated a mitogenic response and favored the adhesion of PDL cells in vitro, suggesting its possible role in periodontal regeneration.
Early Soft Tissue Healing Around One‐Stage Dental Implants: Clinical and Microbiologic Parameters
Authors: DeAngelo Samuel J. , Kumar Purnima S. , Beck Frank M. , Tatakis Dimitris N. , Leblebicioglu Binnaz 
Published: October 2007

Background: Despite the potential significance of early soft tissue healing to long‐term outcomes, this aspect of one‐stage dental implants has not been investigated. The purpose of this prospective study was to characterize clinical and microbiologic parameters of early soft tissue healing around dental implants placed following a one‐stage protocol.Methods: Twenty‐one patients (11 females and 10 males, aged 18 to 78 years; two smokers) needing a single implant were included. Clinical parameters included probing depth, buccal flap thickness, papilla height, and bleeding on probing. Subgingival plaque samples were obtained pre‐ and postoperatively and analyzed using molecular techniques.Results: The newly formed peri‐implant sulcus probing depth remained fairly stable from 4 to 12 weeks (P >0.05). There was no statistically significant association between flap thickness or papillary height and number of implant bleeding sites at 12 weeks (P >0.05). Detection of known periodontal pathogens was rare. Fusobacterium nucleatum was present in 17 patients prior to surgery, and 71% of them became carriers of this bacterium at the implant site by the second postoperative week. The number of F. nucleatum–positive subjects around the implant was significantly lower than the number of F. nucleatum–positive subjects around teeth (P <0.05).Conclusions: Peri‐implant soft tissue clinical maturity may be established as early as 4 weeks following implant placement by a one‐stage surgical protocol; neither preexisting flap thickness nor papillary height seemed to influence newly forming peri‐implant sulcus depth or bleeding on probing prevalence. For the most part, the newly created peri‐implant crevices were colonized by specific bacteria within 2 weeks.
Denervation and High-Fat Diet Reduce Insulin Signaling in T-Tubules in Skeletal Muscle of Living Mice
Authors: Lauritzen Hans P.M. Mortensen , Ploug Thorkil , Ai Hua , Donsmark Morten , Prats Clara , Galbo Henrik 
Published: October 2007

OBJECTIVE—Insulin stimulates muscle glucose transport by translocation of GLUT4 to sarcolemma and T-tubules. Despite muscle glucose uptake playing a major role in insulin resistance and type 2 diabetes, the temporal and spatial changes in insulin signaling and GLUT4 translocation during these conditions are not well described.
RESEARCH DESIGN AND METHODS—We used time-lapse confocal imaging of green fluorescent protein (GFP) ADP-ribosylation factor nucleotide-binding site opener (ARNO) (evaluation of phosphatidylinositide 3-kinase activation) and GLUT4-GFP–transfected quadriceps muscle in living, anesthetized mice either muscle denervated or high-fat fed. T-tubules were visualized with sulforhodamine B dye. In incubated muscle, glucose transport was measured by 2-deoxy-d-[3H]-glucose uptake, and functional detubulation was carried out by osmotic shock. Muscle fibers were immunostained for insulin receptors.
RESULTS—Denervation and high-fat diet reduced insulin-mediated glucose transport. In denervated muscle, insulin-stimulated phosphatidylinositol 3,4,5 P3 (PIP3) production was abolished in T-tubules, while PIP3 production at sarcolemma was increased 2.6-fold. Correspondingly, GLUT4-GFP translocation to T-tubules was abolished, while translocation to sarcolemma was increased 2.3-fold. In high fat–fed mice, a ∼65% reduction in both insulin-induced T-tubular PIP3 production and GLUT4-GFP translocation was seen. Sarcolemma was less affected, with reductions of ∼40% in PIP3 production and ∼15% in GLUT4-GFP translocation. Access to T-tubules was not compromised, and insulin receptor distribution in sarcolemma and T-tubules was unaffected by denervation or high-fat feeding. Detubulation of normal muscle reduced basal and abolished insulin-induced glucose transport.
CONCLUSIONS—Our findings demonstrate, for the first time, that impaired insulin signaling and GLUT4 translocation is compartmentalized in muscle and primarily localized to T-tubules and not sarcolemma during insulin resistance.
Multiple Superoxide Dismutase 1/Splicing Factor Serine Alanine 15 Variants Are Associated With the Development and Progression of Diabetic Nephropathy
Authors: Al-Kateb Hussam , Boright Andrew P. , Mirea Lucia , Xie Xinlei , Sutradhar Rinku , Mowjoodi Alireza , Bharaj Bhupinder , Liu Michelle , Bucksa Jean M. , Arends Valerie L. , Steffes Michael W. , Cleary Patricia A. , Sun Wanjie , Lachin John M. , Thorner Paul S. , Ho Michael , McKnight Amy Jayne , Maxwell A. Peter , Savage David A. , Kidd Kenneth K. , Kidd Judith R. , Speed William C. , Orchard Trevor J. , Miller Rachel G. , Sun Lei , Bull Shelley B. , Paterson Andrew D. ,   the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group
Published: October 2007

BACKGROUND— Despite familial clustering of nephropathy and retinopathy severity in type 1 diabetes, few gene variants have been consistently associated with these outcomes.
RESEARCH DESIGN AND METHODS— We performed an individual-based genetic association study with time to renal and retinal outcomes in 1,362 white probands with type 1 diabetes from the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study. Specifically, we genotyped 1,411 SNPs that capture common variations in 212 candidate genes for long-term complications and analyzed them for association with the time from DCCT baseline to event for renal and retinal outcomes using multivariate Cox proportion hazards models. To address multiple testing and assist interpretation of the results, false discovery rate q values were calculated separately for each outcome.
RESULTS— We observed association between rs17880135 in the 3′ region of superoxide dismutase 1 (SOD1) and the incidence of both severe nephropathy (hazard ratio [HR] 2.62 [95% CI 1.64–4.18], P = 5.6 × 10−5, q = 0.06) and persistent microalbuminuria (1.82 [1.29–2.57], P = 6.4 × 10−4, q = 0.46). Sequencing and fine-mapping identified additional SOD1 variants, including rs202446, rs9974610, and rs204732, which were also associated (P &lt; 10−3) with persistent microalbuminuria, whereas rs17880135 and rs17881180 were similarly associated with the development of severe nephropathy. Attempts to replicate the findings in three cross-sectional case-control studies produced equivocal results. We observed no striking differences between risk genotypes in serum SOD activity, serum SOD1 mass, or SOD1 mRNA expression in lymphoblastoid cell lines.
CONCLUSIONS— Multiple variations in SOD1 are significantly associated with persistent microalbuminuria and severe nephropathy in the DCCT/EDIC study.
Fatty Acids and Insulin Modulate Myocardial Substrate Metabolism in Humans With Type 1 Diabetes
Authors: Peterson Linda R. , Herrero Pilar , McGill Janet , Schechtman Kenneth B. , Kisrieva-Ware Zulfia , Lesniak Donna , Gropler Robert J. 
Published: October 2007

OBJECTIVE—Normal human myocardium switches substrate metabolism preference, adapting to the prevailing plasma substrate levels and hormonal milieu, but in type 1 diabetes, the myocardium relies heavily on fatty acid metabolism for energy. Whether conditions that affect myocardial glucose use and fatty acid utilization, oxidation, and storage in nondiabetic subjects alter them in type 1 diabetes is not well known.
RESEARCH DESIGN AND METHODS—To test the hypotheses that in humans with type 1 diabetes, myocardial glucose and fatty acid metabolism can be manipulated by altering plasma free fatty acid (FFA) and insulin levels, we quantified myocardial oxygen consumption (MVo2), glucose, and fatty acid metabolism in nondiabetic subjects and three groups of type 1 diabetic subjects (those studied during euglycemia, hyperlipidemia, and a hyperinsulinemic-euglycemic clamp) using positron emission tomography.
RESULTS—Type 1 diabetic subjects had higher MVo2 and lower myocardial glucose utilization rate/insulin than control subjects. In type 1 diabetes, glucose utilization increased with increasing plasma insulin and decreasing FFA levels. Myocardial fatty acid utilization, oxidation, and esterification rates increased with increasing plasma FFA. Increasing plasma insulin levels decreased myocardial fatty acid esterification rates but increased the percentage of fatty acids going into esterification.
CONCLUSIONS—Type 1 diabetes myocardium has increased MVo2 and is insulin resistant during euglycemia. However, its myocardial glucose and fatty acid metabolism still responds to changes in plasma insulin and plasma FFA levels. Moreover, insulin and plasma FFA levels can regulate the intramyocardial fate of fatty acids in humans with type 1 diabetes.
Nanostructured Titanium Oxynitride Porous Thin Films as Efficient Visible‐Active Photocatalysts
Authors: Martínez‐Ferrero E. , Sakatani Y. , Boissière C. , Grosso D. , Fuertes A. , Fraxedas J. , Sanchez C. 
Published: October 2007

AbstractNanocrystalline mesoporous N‐doped titania films have been prepared for the first time. The introduction of nitrogen into the anatase structure starts at 500 °C, with N bonding to titanium via oxygen substitution. Increasing the treatment temperature leads to the formation of TiN (TiN1–xOx) and N‐doped rutile showing mixed‐valence Ti states. Microstructural characterization shows that the ordered mesoporosity is maintained until 700 °C, where TiN (TiN1–xOx) begins to form. Optical characterization shows that the discrete introduction of N is able to shift the titania absorption edge. The photocatalytic tests give the best results under visible light excitation for the film nitrided at 500 °C. At this temperature the concentration of nitrogen in the structure is optimal since oxygen vacancies are still not important enough to promote the recombination of the photogenerated electrons and holes.
Polymer Microstructure Control in Catalytic Polymerization Exclusively by Electronic Effects of Remote Substituents
Authors: Bastero Amaia , Göttker‐Schnetmann Inigo , Röhr Caroline , Mecking Stefan 
Published: October 2007

AbstractA series of (κ2‐N,O)salicylaldiminato nickel methyl pyridine complexes 8a–h‐pyr bearing 2,6‐di‐(4‐R′‐phenyl)phenyl groups on the imine nitrogen and varying in the remote substituents [R′=C8F17 (a), CF3 (b), F (7c), H (d), Me (e), tert.‐butyl (f), OMe (g), and NMe2 (h)] were studied as precatalysts for ethylene polymerization. Complexes 8a–h‐pyr catalyze the polymerization of ethylene to low molecular weight polyethylene. Decreasing molecular weight and increasing degrees of branching are observed in the order R′=C8F17≈CF3>F>H>Me>MeO>tert‐butyl>NMe2. X‐Ray diffraction analysis of complex 8c‐pyr and polymerization results obtained with complexes 8‐pyr indicate that it is not the sterics but the electronics of the R′ group that control the polymer microstructure. This is a rare example of a polymerization catalyst in which substituents effects can clearly be traced to electronics exclusively.
Creation of a Monomeric Ruthenium Species on the Surface of Micro‐Size Copper Hydrogen Phosphate: An Active Heterogeneous Catalyst for Selective Aerobic Oxidation of Alcohols
Authors: Liu Junhua , Wang Fang , Sun Kunpeng , Xu Xianlun 
Published: October 2007

AbstractA new micro‐size copper hydrogen phosphate (CHP) synthesized by the emulsion method combined with a monomeric ruthenium species was found to be a very effective catalyst for the selective oxidation of alcohols. Several kinds of alcohols were transformed into the corresponding aldehydes or ketones over the RuCHP catalyst by oxygen under very mild conditions. The results showed that the CHP material was perfect as a catalyst support due to its high ion‐exchange ability and adsorption capacity.
Aerobic, Chemoselective Oxidation of Alcohols to Carbonyl Compounds Catalyzed by a DABCO‐Copper Complex under Mild Conditions
Authors: Mannam Sreedevi , Alamsetti S. Kumar , Sekar G. 
Published: October 2007

AbstractA DABCO‐copper(I) chloride complex (5 mol %) together with TEMPO (5 mol %) in nitromethane as solvent has been used as an efficient catalytic system for the selective oxidation of benzylic and allylic alcohols into the corresponding carbonyl compounds at room temperature where molecular oxygen acts as an ultimate, stoichiometric oxidant and water is the only by‐product. The solid‐state structure determination of the DABCO‐copper complex shows that the copper is in the +II oxidation state with trigonal bipyramidal geometry and exists in a linear polymeric structure due to strong hydrogen bonding.
Highly Selective Synthetic Method for 1,6‐Diols Bearing Enyne Functions: Development of 3,6‐Dianion Reagent of 1,2‐Hexadien‐4‐yne Using 1,6‐Dibromo‐2,4‐hexadiyne and Indium
Authors: Kim Sundae , Lee Kooyeon , Seomoon Dong , Lee Phil Ho 
Published: October 2007

AbstractThe reaction of aldehydes and ketones with an organoindium reagent generated in situ from indium and 1,6‐dibromo‐2,4‐hexadiyne in the presence of lithium iodide in tetrahydrofuran (THF) selectively produced 1,6‐diols linked to an allenyne unit with complete regioselectivity and chemoselectivity through 1,2‐hexadien‐4‐yn‐3,6‐ylation, indicating that the organoindium acted as the 3,6‐dianion reagent of 1,2‐hexadien‐4‐yne.
Economic evaluation of shelf‐space management in grocery stores
Authors: Chung Chanjin , Schmit Todd M. , Dong Diansheng , Kaiser Harry M. 
Published: October 2007

AbstractRecently, many commodity groups have shifted promotion expenditures from generic advertising to non‐advertising activities such as in‐store promotion programs. Accordingly, corresponding evaluation methods need to be developed to identify the benefits of these non‐advertising programs. We develop a general framework to assess product sales performance of in‐store shelf‐space management programs in retail stores. The framework was applied to the evaluation of dairy case management programs in the Northwestern Hudson Valley market, New York. Simulation results on fluid milk product sales indicate that preferred product locations vary between smaller convenience stores and larger supermarket retailers. On average, the dairy case management program was estimated to improve product sales 6 to 10% at the retailer level. [Econlit subject codes: M300, Q130] © 2007 Wiley Periodicals, Inc. Agribusiness 23: 583–597, 2007.
Soluble TWEAK is markedly elevated in hemophagocytic lymphohistiocytosis
Authors: Nagasawa Masayuki , Yi Zhu , Imashuku Shinsaku , Nonoyama Shigeaki , Ogawa Kazuyuki , Okumura Ko , Mizutani Shuki 
Published: October 2007

AbstractTumor necrosis factor‐like weak inducer of apoptosis (TWEAK) is a newly identified monocyte derived cytokine, which has weak apoptosis inducing function against sensitive tumor cell lines in vitro. Also, TWEAK has been reported to have proangiogenic and proinflammatory activities in vivo. However, its functions in pathological situation remain to be elucidated. Here, we analyzed soluble TWEAK in serum of 24 patients with hemophagocytic lymphohistiocytosis (HLH) in combination with interferon‐γ (IFN‐γ) and killer‐specific secretory protein of 37 kDa (Ksp37). Soluble TWEAK was not detected in serum of healthy individuals. Soluble TWEAK was markedly elevated in all six primary HLH patients and 12 of 18 secondary HLH patients. Serum IFN‐γ, which is an only known mediator to stimulate TWEAK production in monocyte in vitro, was not elevated despite elevated serum TWEAK in three of six primary HLH patients, although IFN‐γ was markedly elevated in other cases. Ksp37 was only slightly increased in HLH patients. These results indicate that TWEAK may be involved in pathogenesis of HLH and is useful as a clinical marker. Am. J. Hematol., 2008. © 2007 Wiley‐Liss, Inc.
Superficial venous thrombosis associated with congenital absence of the inferior vena cava and previous episode of deep venous thrombosis
Authors: Evanchuk Darren M. , Von Gehr Ann , Zehnder James L. 
Published: October 2007

AbstractCongenital malformations of the inferior vena cava (IVC) are uncommon and may be associated with an increased risk of venous thrombosis. We report the case of a man with congenital absence of the IVC and remote history of deep venous thrombosis who now presents with severe abdominal wall superficial thrombophlebitis. To our knowledge, this is the first report of a patient with IVC absence who has developed both deep and superficial venous thromboses. Am. J. Hematol., 2008. © 2007 Wiley‐Liss, Inc.
Mortality among workers at the Savannah River Site
Authors: Richardson David B. , Wing Steve , Wolf Susanne 
Published: October 2007

AbstractBackgroundWorkers employed at the Savannah River Site (SRS) were potentially exposed to a range of chemical and physical hazards, many of which are poorly characterized. We therefore compared the observed deaths among workers to expectations based upon death rates for referent populations.MethodsThe cohort included 18,883 SRS workers hired between 1950 and 1986. Vital status and cause of death information were ascertained through 2002. Sex‐specific standardized mortality ratios (SMR) were computed using U.S. and South Carolina mortality rates. SMRs were tabulated separately for monthly‐, weekly‐, and hourly‐paid men.ResultsMales had fewer deaths from all causes [SMR = 0.80, 90% confidence interval (CI): 0.78, 0.82], all cancers (SMR = 0.85, 90% CI: 0.81, 0.89), and lung cancer (SMR = 0.88, 90% CI: 0.82, 0.95) than expected based upon US mortality rates. The SMR for cancer of the pleura was 4.25 (90% CI: 1.99, 7.97) for men. The SMR for leukemia was greater than unity for monthly‐paid (SMR = 1.33, 90% CI: 0.88, 1.93) and hourly‐paid (SMR=1.36, 90% CI: 1.02, 1.78) men. Female workers had fewer deaths from all causes (SMR = 0.75, 90% CI: 0.69, 0.82) than expected, but more deaths than expected from cancer of the kidney (SMR = 2.58, 90% CI: 1.21, 4.84) and skin (SMR = 3.90, 90% CI: 2.11, 6.61).ConclusionsWhile the observed numbers of deaths in most categories of cause of death were less than expected, there are greater than expected numbers of deaths due to cancer of the pleura and leukemia, particularly among hourly‐paid male workers. It is plausible that occupational hazards, including asbestos and ionizing radiation, contribute to these excesses. Am. J. Ind. Med. 50:881–891, 2007. © 2007 Wiley‐Liss, Inc.