bluuebunny/crossref_metadata_2025_split huggingface dataset:
TpPa‐1 COFs‐Enhanced Zwitterion Hydrogel for Efficient Harvesting of Atmospheric Water
Authors: Liu Yueli , Fu Jingchao , Zhu Yuhao , Chen Wen 
Published: March 2024

AbstractZwitterionic hydrogel, serving as carriers for hygroscopic salts, holds significant potential in atmospheric water harvesting. However, their further application is limited by structural collapse in high‐concentration salt solution and poor photothermal conversion performance. Herein, the graded pore structure of poly‐3‐[dimethyl‐[2‐(2‐methylprop‐2‐enoyloxy)ethyl]azaniumyl]propane‐1‐sulfonate (PDMAPS) zwitterionic hydrogel/TpPa‐1 covalent organic frameworks (COFs)/LiCl composite (named as PCL composite hydrogel) is proposed, which leads to the accelerated diffusion effect for water molecules. As a result, the vapor adsorption capacity of the optimal composite hydrogel (PCL‐42) reaches 2.88 g g−1 within 12 hours under conditions of 25 °C and 90 % RH. Simultaneously, the maximum temperature of PCL‐42 composite could reach 53.9 °C after 9 minutes under a simulated solar intensity of 1.0 kW m−2, releasing 91 % of the adsorbed water in 3 hours, providing a promising prospect for efficient solar‐driven atmospheric water harvesting. One cycle could collect 7.55 g of fresh water under outdoor conditions, and the maximum daily water production may reach 2.71 kg kg−1. The reason lies in that TpPa‐1 COFs lead hydrogel to form a gradient pore structure, which may accelerate the transport of water molecules, increase the loading capacity of LiCl and enhance the photothermal property.
Cytomorphological features of sebaceous carcinoma of the breast
Authors: Misawa Ken , Kobayashi Mikiko , Yamamoto Tomoko , Sato Atsushi 
Published: March 2024

AbstractSebaceous carcinoma of the breast is an extremely rare histological subtype of breast cancer, with fewer than 30 cases reported to date. Because of its extremely rare histological presentation, there are few case reports that highlight its cytological findings. In this case report, the cytomorphological features of a sebaceous carcinoma of the breast are described in detail. Cytomorphological analysis revealed atypical cells presenting predominantly as loose clusters. No tubular or papillary structures were evident in the clusters and no mucin production was observed. The diagnosis of sebaceous carcinoma of the breast requires prominent sebaceous differentiation of cells. In Papanicolaou‐stained smears, the differentiated tumor cells were found within the yellowish clusters. When these yellowish clusters were observed at high magnification and shifted out of focus, the sebaceous differentiation of tumor cells could be recognized. This finding is an advantage of observing Papanicolaou‐stained specimens. Like previous reports, some individual cells showing sebaceous differentiation were also observed. In cases where many yellowish clusters appear, close observation of the interior of the clusters can confirm the presence of sebaceous differentiation of tumor cells and serve as a diagnostic clue for the cytological diagnosis of sebaceous carcinoma of the breast.
Electroclinical features of myoclonic‐tonic and spasm‐tonic seizures in childhood
Authors: Taha Mohamed , Nordli Douglas R. , Kacker Shawn , Oetomo Audrey , Phitsanuwong Chalongchai , Nordli Douglas R. 
Published: March 2024

AbstractMyoclonic‐tonic (MT) and spasm‐tonic (ST) seizures represent distinctive features in late infantile epileptic encephalopathy (LIEE). This commentary aims to delineate the electroclinical characteristics of MT and ST seizures, setting them apart from other seizure types. Our analysis encompasses 211 ST and MT seizures observed in 31 patients diagnosed with LIEE, providing a comprehensive overview of video‐EEG features and polygraphic signatures. In MT seizures, EEG findings reveal a high‐voltage diffuse spike/polyspike and wave discharge, often succeeded by diffuse electrodecrements. The amplitude‐integrated EEG (aEEG) signature is described as a “reversed checkmark.” Conversely, ST seizures exhibit EEG findings such as a vertex positive deflection after a slow‐wave and relative electrodecrement, with intermixed epileptiform discharges. In comparison to MT seizures, polygraphic characteristics in ST seizures appear more distinct, featuring a brief rhomboid shape corresponding to the spasm, followed by a lengthier rectangular shape indicative of the tonic phase of the ST seizure. While the pathophysiology of ST and MT seizures remains inadequately understood, their concurrent occurrence and association with other seizure types (tonic, epileptic spasm, myoclonic) within the temporal context of LIEE and other epileptic encephalopathies prompt us to anticipate advancements in our understanding through future research. We hope that this study serves as a foundation for unraveling these complexities in the times to come.
Adaptive fuzzy energy management strategy for range‐extended electric vehicles integrated with deep learning
Authors: Nie Jinquan , Chen Chen , Wei Changyin , Wang Ao , Liu Yuan 
Published: March 2024

AbstractA novel framework for adaptive energy management, rooted in deep learning principles, is proposed to minimize fuel consumption in extended‐range electric vehicles amidst intricate driving scenarios. This innovative approach integrates a long short‐term memory (LSTM) network for pattern recognition across three driving patterns and an adaptive fuzzy controller. To mitigate the impact of poor hyperparameter selection on recognition accuracy, Gray Wolf Optimization is employed to optimize the hidden layer nodes, training times, and learning rate of the LSTM. Simultaneously, a genetic algorithm is utilized to optimize the vertex coordinates of the fuzzy control membership function, enabling the adaptive adjustment of parameters in the fuzzy energy management strategy. The condition recognition model accurately identifies the vehicle's driving status and seamlessly transitions to an energy management strategy tailored to the present conditions. This ensures optimal operation, enhancing overall fuel efficiency and performance. The simulation results robustly validate the efficacy of this approach: the GWO‐LSTM network achieves an impressive 97.7% accuracy in recognizing working conditions, surpassing the 88.9% accuracy of the traditional LSTM network. Furthermore, the fuel consumption reduction achieved by the adaptive fuzzy energy management strategy amounts to 11.9% compared with the conventional fuzzy energy management approach. This outcome underscores the tangible enhancement in vehicle fuel economy resulting from the seamless integration of deep learning techniques.
The effects of dental hygienist autonomy on dental care utilization
Authors: Chen Jie , Meyerhoefer Chad D. , Timmons Edward J. 
Published: March 2024

AbstractWe investigate the effects of regulations governing the practice autonomy of dental hygienists on dental care use with the 2001–2014 Medical Expenditure Panel Survey. We measure the strength of autonomy regulations by extending the Dental Hygiene Professional Practice Index to the years 2001–2014, allowing us to capture changes in regulations within states over time. Using a difference‐in‐differences framework applied to selected states, we find that relaxing supervision requirements to provide dental hygienists moderate autonomy results in an increase in total dental visits due to greater use of preventive dental care. However, the use of dental treatment decreases when states adopt the highest level of autonomy. Both sets of estimates increase in magnitude when we subset the sample to dental care provider shortage areas. In support of these findings, we show that dental visits shift to dental hygienists in shortage areas when states expand the scope of practice of hygienists, and that there is an increase in tasks performed by hygienists, such as cleanings and dental exams.
Drought propagation across meteorological, hydrological and agricultural systems in the Lancang‐Mekong River Basin
Authors: Li Yu , Feng Yunfei , Zhang Bingyao , Zhang Chi 
Published: March 2024

AbstractDrought produces cross‐system impacts, and these interactions between multiple systems are also referred to as drought propagation. However, the complex natural processes and anthropogenic disturbances lead to the drought propagation process being non‐linear and systems feedback, which is still lack of knowledge in large‐scale basins. To address these challenges, we propose a hydro‐economic coupled model and investigate drought propagation across meteorological‐hydrological‐agricultural systems. The results from the Lancang‐Mekong River Basin show that drought propagates from the meteorological system to the hydrological system and is weakened by the basin buffer and storage capacity. This propagation process shows spatial heterogeneity caused by basin characteristics, highlighting that the upstream (CS location) and downstream (KR and KC locations) are more prone to hydrological drought vulnerability. As drought further propagates to the agricultural system, water abstraction behaviours can alleviate the drought situation, leading to crop yield increases ranging from 4.6% to 39.2% through irrigation pathways. Unfortunately, irrigation behaviour also worsens hydrological drought in a feedback loop, where downstream VT (annual discharge decreases by around 1346 m3/s) shows more intense variation than upstream LP (annual discharge decreases by almost 135 m3/s), illustrating the feedback among multi‐systems and accumulation in spatial. Moreover, upstream hydropower and downstream agricultural water use show synergistic relationships, revealing that efficient anthropogenic interventions can positively mitigate the impact of drought on human well‐being. This paper provides an in‐depth understanding of the complex drought propagation process in nature‐human highly coupled Lancang‐Mekong, which may help policymakers and basin managers to better cope with drought.
ADAR2 deficiency ameliorates non‐alcoholic fatty liver disease and muscle atrophy through modulating serum amyloid A1
Authors: Kung Mei‐Lang , Yang Tai‐Hua , Lin Chia‐Chi , Ho Jia‐Yun , Hung Tzu‐Chi , Chang Chih‐Hsiang , Huang Kuan‐Wen , Chen Chien‐Chin , Chen Yun‐Wen 
Published: March 2024

AbstractBackgroundNon‐alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide. Sarcopenia is a syndrome characterized by progressive and generalized loss of skeletal muscle mass and strength, which is commonly associated with NAFLD. Adenosine‐to‐inosine editing, catalysed by adenosine deaminase acting on RNA (ADAR), is an important post‐transcriptional modification of genome‐encoded RNA transcripts. Three ADAR gene family members, including ADAR1, ADAR2 and ADAR3, have been identified. However, the functional role of ADAR2 in obesity‐associated NAFLD and sarcopenia remains unclear.MethodsADAR2+/+/GluR‐BR/R mice (wild type [WT]) and ADAR2−/−/GluR‐BR/R mice (ADAR2 knockout [KO]) were subjected to feeding with standard chow or high‐fat diet (HFD) for 20 weeks at the age of 5 weeks. The metabolic parameters, hepatic lipid droplet, grip strength test, rotarod test, muscle weight, fibre cross‐sectional area (CSA), fibre types and protein associated with protein degradation were examined. Systemic and local tissues serum amyloid A1 (SAA1) were measured. The effects of SAA1 on C2C12 myotube atrophy were investigated.ResultsADAR2 KO mice fed with HFD exhibited lower body weight (−7.7%, P < 0.05), lower liver tissue weight (−20%, P < 0.05), reduced liver lipid droplets in concert with a decrease in hepatic triglyceride content (−24%, P < 0.001) and liver injury (P < 0.01). ADAR2 KO mice displayed protection against HFD‐induced glucose intolerance, insulin resistance and dyslipidaemia. Skeletal muscle mass (P < 0.01), muscle strength (P < 0.05), muscle endurance (P < 0.001) and fibre size (CSA; P < 0.0001) were improved in ADAR2 KO mice fed with HFD compared with WT mice fed with HFD. Muscle atrophy‐associated transcripts, such as forkhead box protein O1, muscle atrophy F‐box/atrogin‐1 and muscle RING finger 1/tripartite motif‐containing 63, were decreased in ADAR2 KO mice fed with HFD compared with WT mice fed with HFD. ADAR2 deficiency attenuates HFD‐induced local liver and skeletal muscle tissue inflammation. ADAR2 deficiency abolished HFD‐induced systemic (P < 0.01), hepatic (P < 0.0001) and muscular (P < 0.001) SAA1 levels. C2C12 myotubes treated with recombinant SAA1 displayed a decrease in myotube length (−37%, P < 0.001), diameter (−20%, P < 0.01), number (−39%, P < 0.001) and fusion index (−46%, P < 0.01). Myogenic markers (myosin heavy chain and myogenin) were decreased in SAA1‐treated myoblast C2C12 cells.ConclusionsThese results provide novel evidence that ADAR2 deficiency may be important in obesity‐associated sarcopenia and NAFLD. Increased SAA1 might be involved as a regulatory factor in developing sarcopenia in NAFLD.
Psychological factors may affect the quality of life in irritable bowel syndrome patients more than the gut itself? A multicenter cross‐sectional study
Authors: Xie Xiaotian , He Jing , Xu Shu , Xu Zhiyue , Long Yanqin , Duan Zhijun , Yang Jie , Zhang Zhifeng , Wu Jun , Cai Lianying , Liang Liexin , Dai Ning , Zhang Jun , Bai Tao , Hou Xiaohua 
Published: March 2024

AbstractBackground and AimBoth intestinal symptoms and comorbidities exist in irritable bowel syndrome (IBS) patients and influence their quality of life (QOL). More research is needed to determine how these variables impact the QOL of IBS patients. This study aimed to determine which specific factors had a higher influence on QOL and to further compare the effects of intestinal symptoms and comorbidities on QOL.MethodsIBS patients were recruited from six tertiary hospitals in different regions of China. QOL, gastrointestinal symptoms, and comorbidities were assessed by different scales. Correlation analysis, multiple linear regression, and mediation model were used for statistics.ResultsFour hundred fifty‐three IBS patients (39.7% women, mean age 45 years) were included and no significant differences in QOL were found across demographic characteristics. Abnormal defecation (r = −0.398), fatigue (r = −0.266), and weakness (r = −0.286) were found to show higher correlation with QOL. More than 40% of IBS patients were found to suffer from varying degrees of anxiety or depression, and anxiety (r = −0.564) and depression (r = −0.411) were significantly negatively correlated with QOL (P < 0.001). Psychological factors showed the strongest impact (β′ = −0.451) and play a strong mediating role in the impact of physiological symptoms on QOL. Anxiety was found to be the strongest factor (β′ = −0.421).ConclusionCompared with other symptoms, psychological symptoms, particularly anxiety, are more common and have a more negative influence on QOL. The QOL of IBS patients is also significantly impacted by abnormal defecation, abdominal distension, and systemic extraintestinal somatic symptoms. In the treatment of IBS patients with unhealthy mental status, psychotherapy might be prioritized.
Synthesis and characterization of novel biheterocyclic compounds from 3‐alkoxy‐1H‐pyrazole‐4‐carbaldehydes via multicomponent reactions
Authors: Savickienė Viktorija , Bieliauskas Aurimas , Belyakov Sergey , Šačkus Algirdas , Arbačiauskienė Eglė 
Published: March 2024

AbstractSeveral series of novel biheterocyclic compounds have been synthesized starting from 3‐alkoxy‐1H‐pyrazole‐4‐carbaldehydes and employing different types of multicomponent reactions. The structures of the obtained 4‐(pyrazol‐4‐yl)pyrano[2,3‐c]pyrazole, 4‐(pyrazol‐4‐yl)pyrazolo[4′,3′:5,6]pyrano[2,3‐b]quinoline, 4‐(pyrazol‐4‐yl)pyridine, and 4‐[(pyrazol‐4‐yl)methylidene]‐1,2‐oxazole derivatives were thoroughly characterized and confirmed using detailed nuclear magnetic resonance spectroscopy (NMR), high‐resolution mass spectrometry (HRMS), infrared spectroscopy (IR), and X‐ray analysis.
Design, synthesis, antimicrobial evaluation, molecular docking studies, and in silico prediction of ADME properties for novel pyrazolo[1,5‐a]pyrimidine and its fused derivatives
Authors: Eldeen Fathi B. Nour , Mousa Sayed A. S. , Othman Ismail M. M. , El‐Qaliei Mohamed I. H. 
Published: March 2024

AbstractDienamine 2 was synthesized by reacting 5‐aminopyrazole 1 with two moles of (DMF DMA). Enamine 2 underwent subsequent reactions with various reagents in different reaction media, leading to the formation of distinct compounds. In an acidic environment, enamine 2 reacted with acetyl acetone, benzoyl acetone, dimedone, and ethyl acetoacetate, resulting in the synthesis of compounds 9a, 9b, 13, and 17, respectively. Conversely, in a basic medium, dienamine 2 combined with malononitrile, ethyl cyanoacetate, and malononitrile dimer, yielding compounds 21a, 21b, and 25. Moreover, by reacting with ammonium acetate in acetic acid, dienamine 2 produced compounds 28. The synthesized compounds underwent in vitro testing against various bacterial and fungal strains, revealing significant antibacterial activity against hazardous bacterial strains. To identify potential bacterial targets, an in‐silico study was initiated. Molecular docking investigations indicated that compound 25 exhibited the highest binding affinity toward dihydrofolate reductase and penicillin‐binding proteins. Furthermore, compound 25 demonstrated robust physiochemical properties, bioavailability, and drug‐like characteristics. These results collectively suggest the potential of compound 25 as a promising antibacterial agent with favorable drug properties.
Multicenter prospective observational study to clarify the current status and clinical outcome in Japanese patients who have an indication for implantable cardioverter defibrillator (ICD) or wearable cardioverter defibrillator (WCD) (TRANSITION JAPAN‐ICD/WCD study): Rationale and design of a prospective, multicenter, observational, comparative study
Authors: Ikeya Yukitoshi , Okumura Yasuo , Kogawa Rikitake , Nagashima Koichi , Nakai Toshiko , Yokoyama Katsuaki , Iso Kazuki , Kato Takeshi , Tsuda Toyonobu , Tachibana Eizo , Hayashida Satoshi , Fukaya Hidehira , Ishizue Naruya , Hayashi Hidemori , Kuroda Shunsuke , Sonoda Kazumasa , Nakahara Shiro , Hori Yuichi , Harada Masahide , Murakami Masato , Iwasaki Yu‐Ki , Aizawa Yoshiyasu , Shimizu Wataru , Fukamizu Seiji , Takami Mitsuru , Kusano Kengo , Ishibashi Kohei , Harada Tomoo , Nakajima Ikutaro , Tabuchi Haruna , Kunimoto Mitsuhiro , Shoda Morio , Higuchi Satoshi , Morishima Itsuro , Kanzaki Yasunori , Kato Ritsushi , Ikeda Yoshifumi , Makimoto Hisaki , Kabutoya Tomoyuki , Kario Kazuomi , Arimoto Takanori , Ninomiya Yuichi , Yoshimoto Issei , Sasaki Shingo , Kondo Yusuke , Chiba Toshinori , Yamashita Kennosuke , Mizuno Yosuke , Inoue Masaru , Ueyama Takeshi , Koyama Jyunjiro , Tsurugi Takuo , Orita Yoshiya , Asano Taku , Shinke Toshiro , Tanno Kaoru , Murotani Kenta ,   For the TRANSITION JAPAN‐ICD/WCD study
Published: March 2024

AbstractBackgroundDespite the positive impact of implantable cardioverter defibrillators (ICDs) and wearable cardioverter defibrillators (WCDs) on prognosis, their implantation is often withheld especially in Japanese heart failure patients with reduced left ventricular ejection fraction (HFrEF) who have not experienced ventricular tachycardia (VT) or ventricular fibrillation (VF) for uncertain reasons. Recent advancements in heart failure (HF) medications have significantly improved the prognosis for HFrEF. Given this context, a critical reassessment of the treatment and prognosis of ICDs and WCDs is essential, as it has the potential to reshape awareness and treatment strategies for these patients.MethodsWe are initiating a prospective multicenter observational study for HFrEF patients eligible for ICD in primary and secondary prevention, and WCD, regardless of device use, including all consenting patients. Study subjects are to be enrolled from 31 participant hospitals located throughout Japan from April 1, 2023, to December 31, 2024, and each will be followed up for 1 year or more. The planned sample size is 651 cases. The primary endpoint is the rate of cardiac implantable electronic device implementation. Other endpoints include the incidence of VT/VF and sudden death, all‐cause mortality, and HF hospitalization, other events. We will collect clinical background information plus each patient's symptoms, Clinical Frailty Scale score, laboratory test results, echocardiographic and electrocardiographic parameters, and serial changes will also be secondary endpoints.ResultsNot applicable.ConclusionThis study offers invaluable insights into understanding the role of ICD/WCD in Japanese HF patients in the new era of HF medication.
Evaluating the Alaska Blocking Index as an indicator of wildfire potential in Alaska's central eastern interior
Authors: Ballinger Thomas J. , Lader Rick T. , Bieniek Peter A. , Strader Heidi , Ziel Robert , Bhatt Uma S. , Borries‐Strigle Cecilia , Hostler Joshua , Stevens Eric , Waigl Christine F. , York Alison 
Published: March 2024

AbstractIncreased Arctic air temperatures and evaporative fluxes have coincided with more frequent and destructive high‐latitude wildfires. Arctic fires impact ecosystems and people, especially at the community‐level by degrading air quality, destroying agriculture, and threatening life and property. Central Eastern Interior (CEI) Alaska is one such region that has recently experienced the effects of wildfire activity related to warming air temperatures. To improve our ability to identify fire weather events and assess their potential for extreme outbreaks at actionable lead times relevant to fire weather forecasters and managers, new metrics and approaches need to be established and applied toward understanding the physical mechanisms underlying such wildland fire characteristics. Our study uses a new, regional atmospheric circulation metric, the Alaska Blocking Index (ABI), to describe midtropospheric air pressure around Alaska, which is subsequently related to CEI fire weather conditions at the Predictive Service Area (PSA) scale in climatological and extreme events frameworks. Of note, during years of high fire activity, Build‐Up Index (BUI) values tend to be anomalously high during the duff and drought phases across the CEI PSAs, though comparatively lower BUI values are still associated with high fire activity in the Tanana Zone‐South (AK03S) PSA. Likewise, extreme BUI values are strongly tied to high ABI values and well‐defined upper‐air ridging circulation patterns in the duff and drought periods. The statistical skill of mean daily ABI values in the 6–10 day period preceding extreme duff period BUI values is modest (τ2 > 14%) in the Upper Yukon Valley (AK02) PSA, a hotbed of wildland fire activity. Extremes in ABI and CEI BUI often occur in tandem, yielding regional predictability of upper‐air weather patterns and extremes and underlying surface weather conditions, by statistical and/or dynamical forecast models, imperative for local community and governmental organizations to effectively manage and allocate Alaska's fire weather resources.