bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nucleic acid-sensing-related gene signature in predicting prognosis and treatment efficiency of small cell lung cancer patients
Authors: Liu Qianshi , Li Zhaoshen , Li Na , Liu Junjie , Wu Hong , Chen Jie 
Published: April 2024

IntroductionNucleic acid-sensing (NAS) pathways could induce innate and adaptive immune responses. However, rare evidence exhibited how the core genes of the NAS pathways affected the immune response and prognosis of small cell lung cancer (SCLC) patients.MethodsWe conducted a comprehensive bioinformatic analysis based on the RNA profiles of 114 SCLC patients, including 79 from cBioPortal, 21 from GSE30219, and 14 from our sequencing data. The multiplex immunohistochemistry (mIHC) was used to characterize the role of NAS related genes in the tumor microenvironment (TME) of SCLC.ResultsA prognostic model (7NAS risk model) was constructed based on 7 NAS-related genes which was demonstrated as an independent prognostic index. The low-risk group was identified to have a better prognosis and an immune-activated microenvironment in both the public datasets and our dataset. Intriguingly, mIHC data showed that CD45+ immune cells, CD8+ T lymphocytes, and CD68+ macrophages were prevalently enriched in low-risk SCLC patients and positively correlated with IRF1 expression. Additionally, Patients in the low-risk group might have superior responses to chemotherapy and immunotherapy.ConclusionConclusively, this study created a new risk model based on genes associated with NAS pathways which could predict the prognosis and response of treatment in patients with SCLC.
Hydrogen-rich water supplementation promotes muscle recovery after two strenuous training sessions performed on the same day in elite fin swimmers: randomized, double-blind, placebo-controlled, crossover trial
Authors: Sládečková Barbora , Botek Michal , Krejčí Jakub , Valenta Michal , McKune Andrew , Neuls Filip , Klimešová Iva 
Published: April 2024

Purpose: Molecular hydrogen has been shown to possess antioxidant, anti-inflammatory, ergogenic, and recovery-enhancing effects. This study aimed to assess the effect of molecular hydrogen administration on muscle performance, damage, and perception of soreness up to 24 h of recovery after two strenuous training sessions performed on the same day in elite fin swimmers.Methods: Eight females (mean ± SD; age 21.5 ± 5.0 years, maximal oxygen consumption 45.0 ± 2.5 mL.kg−1.min−1) and four males (age 18.9 ± 1.3 years, maximal oxygen consumption 52.2 ± 1.7 mL.kg−1.min−1) performed 12 × 50 m sprints in the morning session and a 400 m competitive performance in the afternoon session. Participants consumed hydrogen-rich water (HRW) or placebo 3 days before the sessions (1,260 mL/day) and 2,520 mL on the experimental day. Muscle performance (countermovement jump), muscle damage (creatine kinase), and muscle soreness (100 mm visual analogue scale) were measured during the experimental day and at 12 and 24 h after the afternoon session.Results: HRW compared to placebo reduced blood activity of creatine kinase (156 ± 63 vs. 190 ± 64 U.L−1, p = 0.043), muscle soreness perception (34 ± 12 vs. 42 ± 12 mm, p = 0.045), and improved countermovement jump height (30.7 ± 5.5 cm vs. 29.8 ± 5.8 cm, p = 0.014) at 12 h after the afternoon session.Conclusion: Four days of HRW supplementation is a promising hydration strategy for promoting muscle recovery after two strenuous training sessions performed on the same day in elite fin swimmers.Clinical Trial Registration:clinicaltrials.gov, identifier NCT05799911
Parental recovered acute kidney injury causes prenatal renal dysfunction and fetal growth restriction with sexually dimorphic implications for adult offspring
Authors: Hebert Jessica F. , Funahashi Yoshio , Emathinger Jacqueline M. , Nickerson Megan N. , Groat Tahnee , Andeen Nicole K. , Gurley Susan B. , Hutchens Michael P. 
Published: April 2024

Introduction: Acute kidney injury (AKI) is rapidly increasing in global incidence and a healthcare burden. Prior maternal AKI diagnosis correlates with later pregnancy complications. As pregnancy influences developmental programming, we hypothesized that recovered parental AKI results in poor pregnancy outcomes, impaired fetal growth, and adult offspring disease.Methods: Using a well-characterized model of rhabdomyolysis-induced acute kidney injury (RIAKI), a form of AKI commonly observed in young people, we confirmed functional renal recovery by assessing glomerular filtration rate (GFR) 2 weeks following RIAKI. We bred sham and recovered RIAKI sires and dams in timed, matched matings for gestational day (GD) 16.5 and offspring (birth–12 weeks, 6 months) study.Results: Despite a normal GFR pre-pregnancy, recovered RIAKI dams at GD16.5 had impaired renal function, resulting in reduced fetoplacental ratios and offspring survival. Pregnant RIAKI dams also had albuminuria and less renal megalin in the proximal tubule brush border than shams, with renal subcapsular fibrosis and higher diastolic blood pressure. Growth-restricted offspring had a reduced GFR as older adults, with evidence of metabolic inefficiency in male offspring; this correlated with reduced renal AngII levels in female offspring from recovered RIAKI pairings. However, the blood pressures of 6-month-old offspring were unaffected by parental RIAKI.Conclusions: Our mouse model demonstrated a causal relationship among RIAKI, gestational risk, and developmental programming of the adult-onset offspring GFR and metabolic dysregulation despite parental recovery.
Cognitive, emotional, and social factors promoting psychosocial adaptation: a study of latent profiles in people living in socially vulnerable contexts
Authors: Carriedo Nuria , Rodríguez-Villagra Odir A. , Moguilner Sebastián , Morales-Sepulveda Juan Pablo , Huepe-Artigas Daniela , Soto Vicente , Franco-O’Byrne Daniel , Ibáñez Agustín , Bekinschtein Tristan A. , Huepe David 
Published: April 2024

IntroductionSocial adaptation is a multifaceted process that encompasses cognitive, social, and affective factors. Previous research often focused on isolated variables, overlooking their interactions, especially in challenging environments. Our study addresses this by investigating how cognitive (working memory, verbal intelligence, self-regulation), social (affective empathy, family networks, loneliness), and psychological (locus of control, self-esteem, perceived stress) factors interact to influence social adaptation.MethodsWe analyzed data from 254 adults (55% female) aged 18 to 46 in economically vulnerable households in Santiago, Chile. We used Latent profile analysis (LPA) and machine learning to uncover distinct patters of socioadaptive features and identify the most discriminating features.ResultsLPA showed two distinct psychosocial adaptation profiles: one characterized by effective psychosocial adaptation and another by poor psychosocial adaptation. The adaptive profile featured individuals with strong emotional, cognitive, and behavioral self-regulation, an internal locus of control, high self-esteem, lower stress levels, reduced affective empathy, robust family support, and decreased loneliness. Conversely, the poorly adapted profile exhibited the opposite traits. Machine learning pinpointed six key differentiating factors in various adaptation pathways within the same vulnerable context: high self-esteem, cognitive and behavioral self-regulation, low stress levels, higher education, and increased social support.DiscussionThis research carries significant policy implications, highlighting the need to reinforce protective factors and psychological resources, such as self-esteem, self-regulation, and education, to foster effective adaptation in adversity. Additionally, we identified critical risk factors impacting social adaptation in vulnerable populations, advancing our understanding of this intricate phenomenon.
First validation of the technical and administrative staff quality of life at work tool (TASQ@work) in academia
Authors: Bruno Andreina , Buono Carmela , Falco Alessandra , Brondino Margherita , Capone Vincenza , Dell’Aversana Giuseppina , Giancaspro Maria Luisa , Gilardi Silvia , Girardi Damiano , Guglielmi Dina , Ingusci Emanuela , Miglioretti Massimo , Pace Francesco , Platania Silvia , Signore Fulvio , Spagnoli Paola 
Published: April 2024

IntroductionBased on the job demands-resources (JD-R) model, the present study aimed to validate “The Technical and Administrative Staff Quality of Life At Work” (TASQ@work), a new tool to assess the quality of life at work in academia focused on technical and administrative staff.MethodsThis tool was developed by the QoL@Work research team, a group of expert academics in the field of work and organizational psychology affiliated with the Italian Association of Psychologists. The TASQ@work was elaborated in different steps. The first phase was aimed at the identification of the dimensions of the tool. The second phase was aimed to assess the psychometric properties of the tool. The validation process involved confirmatory analysis and measurement invariance of the various constructs selected. The analyses were performed in a convenience sample of two Italian universities in different regions (one in the Northwest and the second in Central Italy).ResultsThe sample was composed of 1820 Administrative Staff, comprising 69.4% from University 1 (N = 1,263) and 30.6% from University 2 (N = 557). The TASQ@work presented satisfactory psychometric properties (normality of the items, reliability and content, construct and nomological validity) and measurement invariance across gender, seniority, and Athenaeum.DiscussionThe results indicate that the tool can be considered a reliable and valid instrument to assess job demands, job resources, and outcomes in the working life of technical and administrative academic staff. In this perspective, the present study represents the first contribution to the debate on the psychosocial risks in academic contexts by presenting a new tool, the TASQ@work, aimed at contextualizing the JD-R model to understand the role played by psychosocial aspects in affecting the well-being of the academic employees.
Trans narratives on school experiences—This is how we feel
Authors: Etxebarria-Perez-de-Nanclares Olatz , Vizcarra Morales Maria Teresa , López-Vélez Ana Luisa , Gamito Gómez Rakel 
Published: April 2024

IntroductionThe school environment remains unsafe for many trans people, where they are victims of discrimination, aggression, and bullying, resulting in socioemotional and physical harm to trans individuals. Intersectionality and minority stress are contributing factors in this already challenging education environment. In many cases, the voices of trans people are not heard or listened to at school; therefore, this study aims to listen to their school experiences in order to identify key areas for improvement.MethodThis study implemented a narrative research approach where six in-depth interviews were completed with trans participants from the Basque Country, Europe, and the United States of America that focused on five dimensions: being a trans, the role of school, lack of teacher education and training, segregation by gender, and socioemotional wellbeing. The transcriptions of these interviews were coded using Nvivo software in categorical systems in a deductive and inductive way.ResultsThe results clearly showed that the binary society has a negative impact on trans people. In addition, the educational environment is still hostile for most of them, in which the lack of teacher training and gender identity content in the curriculum has a negative impact on trans people and their experiences at school.DiscussionThe findings support the idea that socially ingrained binarism is detrimental to all those who step outside the norm. It can also be said that the earlier the transition is made, the better the effect (clinical as well as socioemotional) on their personal lives. For this early transition to occur, it is necessary to have access to information from an early age.
A Surface Hydrothermal Source of Nitriles and Isonitriles
Authors: Rimmer Paul B. , Shorttle Oliver 
Published: April 2024

Giant impacts can generate transient hydrogen-rich atmospheres, reducing atmospheric carbon. The reduced carbon will form hazes that rain out onto the surface and can become incorporated into the crust. Once heated, a large fraction of the carbon is converted into graphite. The result is that local regions of the Hadean crust were plausibly saturated with graphite. We explore the consequences of such a crust for a prebiotic surface hydrothermal vent scenario. We model a surface vent fed by nitrogen-rich volcanic gas from high-temperature magmas passing through graphite-saturated crust. We consider this occurring at pressures of 1–1000bar and temperatures of 1500–1700 ∘C. The equilibrium with graphite purifies the leftover gas, resulting in substantial quantities of nitriles (0.1% HCN and 1ppm HC3N) and isonitriles (0.01% HNC) relevant for prebiotic chemistry. We use these results to predict gas-phase concentrations of methyl isocyanide of ∼1 ppm. Methyl isocyanide can participate in the non-enzymatic activation and ligation of the monomeric building blocks of life, and surface or shallow hydrothermal environments provide its only known equilibrium geochemical source.
Efeito crônico do pré-condicionamento isquêmico na função vascular: revisão sistemática
Authors: Lima Souza Pedro , Cunha Nascimento Amaral Thamara , Martins Coelho Marcelo , Fernandes Trevizan Patrícia , Camaroti Laterza Mateus , Martinez Daniel Godoy 
Published: April 2024

Introdução: O pré-condicionamento isquêmico (PCI) tem demostrado efeito protetor aos tecidos contra danos isquêmicos subsequentes, já que aparenta estar relacionado aos mecanismos vasodilatadores vasculares. Sabe-se que uma sessão aguda de PCI traz efeitos vasodilatadores endotélio dependente. Objetivo: Revisar sistematicamente o efeito crônico da realização do PCI sobre a função vascular. Métodos: Foi realizada pesquisa bibliográfica nas bases de dados eletrônicas Medline, Cochrane, Embase, Lilacs, SciElo, Web of Science e Scopus, sendo considerados ensaios clínicos controlados publicados até fevereiro de 2022. As buscas foram realizadas utilizando os descritores: Ischemic preconditioning; Preconditioning, Ischemic; Ischemic Pre-Conditioning; Ischemic Pre Conditioning; Pre-Conditioning, Ischemic; regional blood flow; Vascular Endothelium; Vasodilatation; Endothelium, vascular. Os artigos incluídos após análise de elegibilidade tiveram sua qualidade metodológica avaliada por meio da escala de classificação Downs and Black. Resultados: Foram encontrados 622 artigos dos quais apenas 11 preencheram os critérios de elegibilidade. Os 11 artigos possuíam uma população heterogênea composta por jovens saudáveis, pessoas com diagnóstico de diabetes Mellitus, doença arterial coronariana, hipertensão arterial sistêmica e acidente vascular encefálico, além de tabagistas. Foi demonstrado melhora da função vascular após a aplicação do protocolo de PCI de forma crônica. Adicionalmente, cinco desses artigos demostraram a melhora da função vascular por via dependente do endotélio, três por via endotélio independente e outros três estudos melhora tanto de forma dependente quanto independente. Conclusão: O PCI aplicado de forma crônica parece melhorar a função vascular, tanto por via endotélio dependente como independente.
Custo do tratamento fisioterapêutico no pós-operatório de reconstrução do ligamento cruzado anterior em um Hospital Universitário de Minas Gerais
Authors: Monteiro Veras Priscila , Fontes Loures Liliany , De Paiva Loures Alan , Gabriella De Vasconcelos Novaes Rosana , Simões Fonseca Diogo , Barbosa Vieira Bruno , De Moura Reboredo Maycon 
Published: April 2024

Introdução: As lesões do ligamento cruzado anterior são recorrentes em praticantes de atividade esportiva. O tratamento cirúrgico apresenta custo benefício adequado, porém ao adicionar o tratamento fisioterapêutico pós- operatório o impacto para o sistema de saúde se torna mais elevado. Os custos na área de saúde são relevantes, pois é essencial que a gestão domine e conheça os processos dos dispêndios. Objetivo: Avaliar os custos envolvidos no processo de reabilitação após cirurgia de reconstrução do LCA em um Hospital Universitário e comparar esses custos com o valor acordado com o gestor público local para tratamento fisioterapêutico. Materiais e Métodos: Estudo observacional e retrospectivo. Os dados foram coletados analisando os prontuários eletrônicos do Sistema Aplicativo de Gestão para Hospitais Universitários do Ambulatório de Fisioterapia, sendo a amostra por conveniência. Resultados: Nove pacientes foram elegíveis para este estudo. O custo médio por sessão de fisioterapia foi de R$ 100,30. Assim, o custo total médio da reabilitação pós-operatória do LCA por paciente foi de R$ 2.507,50, correspondendo a um período médio de intervenção de 25 sessões. Conclusão: O custo médio por intervenção fisioterapêutica no pós-operatório de reconstrução do LCA foi de R$ 100,30, valor muito superior ao acordado com o gestor local.
Preparação alcoólica para antissepsia cirúrgica das mãos
Authors: De Brito Ângelo Bárbara Helena , Facundes Érika Michelle do Nascimento , Paiva Giselle Souza de , Nascimento Kheyla Santos , Nascimento Lúcia Reis do , Silva Naélia Vidal de Negreiros , Cavalcanti Nara Gualberto , Cunha Rayssa Berenguer de Araújo 
Published: April 2024

Introdução: A infecção de sítio cirúrgico é um processo infeccioso que apresenta correlação com falhas na antissepsia cirúrgica das mãos dos profissionais da equipe cirúrgica. Objetivo: Analisar o conhecimento científico a respeito da eficácia da antissepsia cirúrgica das mãos de profissionais de saúde com preparação alcoólica em comparação com a tradicional técnica de lavagem das mãos. Material e Métodos: Revisão integrativa a partir de ensaios clínicos randomizados, estudos quase-experimentais e revisões sistemáticas (com ou sem meta-análise). O processo de busca foi realizado por um pesquisador, que utilizou os seguintes descritores e termos correlatos em português e inglês: “antissepsia” OR “desinfecção das mãos” OR “higiene das mãos” AND “controle de infecções” AND “centros cirúrgicos” OR “cirurgia”. Foram consultadas as bases de dados Medical Literature Analysis and Retrievel System Online (MEDLINE/PubMed), Cochrane Database of Systematic Reviews, Literatura Latino-Americana e do Caribe em Ciências da Saúde (Lilacs) e Base de Dados de Enfermagem (BDENF). Outras fontes consultadas foram os sites da Rede Brasileira de Avaliação Tecnologias em Saúde (Rebrats), National Institute for Clinical Excellence (Nice), UpToDate, Registro Brasileiro de Ensaios Clínicos (ReBEC) e Google Acadêmico. Resultados: Os dados analisados indicaram não haver diferença estatisticamente significativa entre as taxas de infecção de sítio cirúrgico nos estudos que compararam a fricção das mãos com solução alcoólica em relação à lavagem com o comparador à base de polivinil pirrolidona iodo ou clorexidina. Conclusão: Apesar da análise dos resultados dos estudos incluídos na amostra não demonstrarem diferença estatisticamente significativa na contagem de unidades formadoras de colônias, a antissepsia cirúrgica das mãos por fricção é recomendada por apresentar fácil aplicação, menor consumo de tempo, baixos níveis de irritações cutâneas e melhor tolerância dérmica.
La qualification de l’emploi, instrument d’une nouvelle politique sociale
Authors: Ducray Gabriel 
Published: April 2024

Parmi les éléments fondamentaux de la politique économique et sociale contemporaine s’est imposée, dans les années soixante, la nécessité de l'éducation permanente. Ainsi la France s’est trouvée dotée d’un système juridique très élaboré qui, avec l’accord interprofessionnel du 9 juillet 1970 et les lois du 16 juillet 1971, a inscrit, dans le prolongement de la loi du 3 décembre 1966, la formation des adultes dans la réalité des relations professionnelles et des conditions de travail. Mais ce remarquable instrument de formation se heurte à un obstacle majeur : pour le formateur, le monde de l'emploi est une inconnue. Il s'agissait donc d’améliorer la connaissance de la prévision de l’emploi : la qualification de l’emploi s’est révélée un des instruments de travail indispensable pour y parvenir. Elle permet une démarche originale susceptible de s’appliquer à trois niveaux : les secteurs économiques, les entreprises, le marché du travail.
Afin d’adapter les méthodes et les contenus des enseignements à l’évolution de la société, le formateur doit pouvoir appréhender les évolutions structurelles par une observation qualitative de l’emploi. En effet, celle-ci permet d’une part de procéder à un repérage des emplois grâce à la mise au point d’un véritable «répertoire», d’autre part d’identifier des facteurs d’évolution, d’en apprécier les effets sur l’activité des hommes et des femmes et par là de déterminer les zones critiques.
Mais il faut rendre également les situations de travail compréhensibles aux formateurs dans le contexte de l’entreprise, car ce sont les évolutions des unes et des autres qui détermineront les besoins de formation. En considérant l’entreprise comme milieu socio-technique, en dégageant la notion d’équipe fonctionnelle, en analysant le langage technologique, support des connaissances utilisées, le Centre d'études et de recherches sur les qualifications s’est appliqué à mettre au point un instrument d’analyse capable de relier les compétences utilisées aux formations.
Enfin, la qualification du marché du travail doit préciser l'importance et le degré des phénomènes souvent dénoncés d’inadaptation des capacités des demandeurs d’emploi aux compétences recherchées par les entreprises. Trois sources d’information ne sont pas à cet égard suffisamment exploitées : les offres, les demandes d’emploi et les placements réalisés. Disposant de ces informations l'Agence Nationale pour l’Emploi pourrait renforcer ses actions en prenant simultanément en considération les caractéristiques de la formation et les besoins de l’entreprise.
Ainsi la qualification de l’emploi, à laquelle est attaché le CEREQ, se révèle capable de mobiliser la force créatrice de la formation professionnelle au service d’une politique de l’emploi.
Les choix professionnels d’élèves de classe terminale Premiers résultats d’une enquête
Authors: Larcebeau Solange 
Published: April 2024

Nous avons lancé en 1977, auprès d’un échantillon d’élèves de classe Terminale, une enquête longitudinale d’une durée minimum de trois ans, cet intervalle devant permettre à ceux des sujets qui entreprendraient des études post-secondaires d’achever le premier cycle de l’enseignement supérieur.
L’objectif de cette recherche est l’étude des projets professionnels d’élèves de Terminale et des relations entre projets et motivation à entreprendre et à poursuivre des études supérieures.
L’article présente les premiers dépouillements de l’enquête effectuée en classe Terminale concernant le choix professionnel et les raisons du choix, et leurs variations en fonction du sexe et de la section.
A travers les réponses des élèves, on a tenté de préciser le degré de décision, de réalisme et de cohérence de leurs projets, le niveau d’organisation de leurs intérêts et de leurs valeurs, afin d’éprouver les hypothèses des théories du développement «vocationnel» assimilant à la période de transition vers le stade «réaliste» l’âge moyen des sujets de notre échantillon.