bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adult‐onset still's disease
Authors: Cush John J. , Medsger Thomas A. , Christy Wallace C. , Herbert David C. , Cooperstein Lawrence A. 
Published: February 2007

AbstractWe reviewed the long‐term natural history of 21 adult‐onset Still's disease patients. Patient subsets were identified according to clinical course patterns. These included monocyclic systemic disease in 4, polycyclic systemic disease in 2, chronic articular monocyclic systemic disease in 10, and chronic articular polycyclic systemic disease in the remaining 5 patients. Functional outcome differed according to course patterns and the extent of articular involvement. Systemic manifestations, per se, did not contribute to poor functional prognosis. Chronic articular disease had the worst outcome: 27% evolved to functional class III status, compared with none in the cyclic systemic groups. Those patients who had a chronic articular pattern or a polyarticular onset and course were at higher risk to develop disabling arthritis. An aggressive approach to therapy, including the early use of remittive agents, should be considered in these patient subsets.
Drug‐induced peripheral neuropathy in a patient with psoriatic arthritis
Authors: Rothenberg Ralph J. , Sufit Robert L. 
Published: February 2007

AbstractA patient with psoriatic arthritis developed a peripheral neuropathy while taking hydroxychloroquine and naproxen. Although it was initially suspected that hydroxychloroquine was responsible for the neuropathy, subsequent rechallenge with naproxen demonstrated that clinical and electrophysiologic findings were related to routine pharmacologic doses of naproxen.
Airways disease in rheumatoid arthritis patients
Authors: Radoux V. , Méanard H. A. , Béagin R. , Déacary F. , Koopman W. J. 
Published: February 2007

AbstractAirflow limitation is a frequent finding in patients with rheumatic diseases. We have previously suggested that it is associated with autoimmune exocrinopathy in Sjögren's syndrome. To compare clinical features of patients with and without airways dysfunction and to further test the hypothesis of a link between airways disease and exocrinopathy, we prospectively studied 2 groups of 15 lifetime nonsmoker female patients with seropositive rheumatoid arthritis (RA). The 2 groups were similar in their clinical and immunologic features, but differed in terms of airways function. Salivary, lacrimal, and sweat gland dysfunction were significantly more prevalent or severe in the group with airways disease. Antinuclear antibodies were also more prominent in the patients with airways disease, but antibodies against RNP, SS‐A, SS‐B, and double‐stranded DNA were not present in these patients. HLA‐DR4 was found in 80% of the RA patients with airways disease and in 57% of those without airways disease. HLA–B8 and DR3 were equivalently distributed in both groups. This prospective study further documents the existence of small airways disease in RA and supports the view that autoimmune exocrinopathy predisposes to its expression.
IgM rheumatoid factor plaque‐forming cells in juvenile rheumatoid arthritis
Authors: Moore Terry L. , El‐Najdawi Eva , Dorner Robert W. 
Published: February 2007

AbstractUsing a direct, plaque‐forming cell (PFC) assay with sensitized sheep erythrocytes, lymphocytes that secrete IgM rheumatoid factors (RF) have been detected in the peripheral blood of patients with juvenile rheumatoid arthritis. Of 15 juvenile rheumatoid arthritis patients tested, 8 were seropositive and 7 were seronegative, but 6 of the seronegative patients had hidden 19S IgM‐RF. Ten patients (5 seropositive and 5 with hidden 19S IgM‐RF) demonstrated RF‐PFC in their peripheral blood (range 15 to >200 RF‐PFC/106 mononuclear cells). Of 11 patients who had active disease, 10 had RF‐PFC, and the 4 patients who had inactive disease had no PFC in their peripheral blood. HLA typing of all 15 patients revealed no correlation between the presence of RF‐PFC and HLA type.
Mseleni disease serum is not harmful to cultured chondrocytes
Authors: Changlong Yu , Fincham John E. , Wright George C. , Taljaard Joshua J. F. , Sokoloff Leon 
Published: February 2007

AbstractThe origins of Mseleni disease, an acquired polyarticular degenerative joint disease, are unknown. We examined sera from 12 patients with the disease, 5 unaffected Mseleni residents, and 5 Durban residents. The effects of sera from the 12 patients with Mseleni disease on DNA or sulfated proteoglycan synthesis by cultured rabbit or human infant articular chondrocytes were no different from those of control sera. Cells derived from 2 children contained no stainable DR antigens; coculture had no impact on either of the above measures of cell function.
Procollagen gene expression by scleroderma fibroblasts in culture. inhibition of collagen production and reduction of proα(i) and proα1(III) collagen messenger RNA steady‐state levels by retinoids
Authors: Ohta Akihide , Uitto Jouni 
Published: February 2007

AbstractRecent studies have demonstrated that retinoids (synthetic vitamin A analogs) can modulate connective tissue metabolism in human skin fibroblast cultures. In this study, we examined the effects of 3 retinoids, all‐trans‐retinoic acid (RA), 13‐cis‐RA, and an aromatic retinoid, RO‐10–9359, on collagen gene expression in scleroderma fibroblast cultures and matched control fibroblast cultures. The results indicated that all‐trans‐RA and 13‐cis‐RA significantly reduced procollagen production both in control and scleroderma fibroblast cultures in a dose‐dependent manner. The reduction in procollagen production was paralleled by a similar decrease in steady‐state levels of type I and type III procollagen messenger RNAs, which suggests that there is coordinate inhibition on the transcriptional level. In contrast, RO‐10–9359 elicited only limited effects on collagen production, and such effects were variable. The results suggest that further development of retinoids might provide an effective means to counteract tissue deposition of collagen in scleroderma and other fibrotic diseases.
Successful joint arthroplasty following proteus morganii (morganella morganii) septic arthritis: a four‐year study
Authors: Katz Linda M. , Lewis Randall J. , Borenstein David G. 
Published: February 2007

AbstractProteus morganii (Morganella morganii) is an uncommon cause of septic arthritis. We describe a 53‐year‐old woman with severely deforming rheumatoid arthritis, who developed an indolent septic arthritis secondary to infection with this organism. She was treated with antibiotics and closed drainage, and subsequently, underwent successful arthroplasty. She continues to do well 4.5 years later. This patient's disease course shows that gram‐negative septic arthritis, effectively treated, does not preclude successful total joint arthroplasty.
Rheumatoid nodules of the spine: case report and review of the literature
Authors: Pearson Mark E. , Kosco Mary , Huffer William , Winter William , Engelbrecht James A. , Steigerwald James C. 
Published: February 2007

AbstractWe present the case of a patient who had rheumatoid nodules of the vertebrae, which had resulted in bony destruction of the spine at 3 levels. Although there have been only 3 previous reports of such findings with confirmation by histologic analysis, we believe the condition is more common than has been thought. From a review of the literature, we found that similar clinical and radiographic features, as well as descriptions of rheumatoid granulation tissue invading the disc spaces, have been described in several subjects.
Stimulation of b cell differentiation by adherent mononuclear cells in systemic lupus erythematosus
Authors: Jandl Robert C. , Adirim Terry A. , Schur Peter H. 
Published: February 2007

AbstractWe studied B cell proliferation and differentiation in response to factors released by adherent monocytes in patients with systemic lupus erythematosus (SLE). Adherent cell supernatants (ACS) were added to peripheral blood mononuclear cells, and the effects on IgG synthesis, the number of Ig‐secreting cells (ISC), and proliferation were determined. Exposure of SLE mononuclear cells to autologous ACS caused an increase (approximately twofold) in IgG production and ISC numbers. In contrast, exposure of normal mononuclear cells to autologous ACS did not significantly increase IgG production or ISC numbers. Addition of SLE ACS to cultures of normal mononuclear cells did not stimulate ISC production. There was no significant level of 3H‐thymidine uptake by cultures of SLE or normal mononuclear cells in response to either SLE or normal ACS. In the presence of an excess number of autologous T cells, ACS stimulation of IgG synthesis was further enhanced. These findings indicate that adherent monocytes contribute to B cell hyperactivity in SLE by stimulating B cell differentiation. SLE mononuclear cells appear to be more responsive to ACS stimulation than are normal mononuclear cells.
Histopathology of arthritis induced in rats by active immunization to mycobacterial antigens or by systemic transfer of t lymphocyte lines. a light and electron microscopic study of the articular surface using cationized ferritin
Authors: Stanescu Ritta , Lider Ofer , Eden Willem Van , Holoshitz Joseph , Cohen Irun R. 
Published: February 2007

AbstractWe analyzed the histopathologic findings of arthritis in 3 rat models: adjuvant arthritis induced by active immunization to Mycobacterium tuberculosis (MT) antigens, arthritis produced by passive transfer of an intrinsically arthritogenic line of anti‐MT T lymphocytes, and bystander arthritis produced by intra‐articular injection of a foreign antigen, ovalbumin, into rats with T lymphocyte line cells specific for the ovalbumin antigen. The histopathology of the tibiotarsal and knee joints was studied by light microscopy and the articular surface of the cartilage by electron microscopy after labeling with cationized ferritin. The lesions in the 3 models of arthritis were compared. In active adjuvant arthritis, inflammatory lesions and cartilage destruction were found as early as 9 days after immunization, and persisted for as long as 11 months. Similar, but somewhat milder, lesions were found in arthritis produced by transfer of anti‐MT T lymphocytes. Inflammatory signs were present at 4 days, when there was no evidence of joint edema. Severe inflammatory lesions were found in arthritis induced by transfer of anti‐ovalbumin T lymphocytes that was followed by ovalbumin injection into the knee. Pathologic changes were found to be similar in all 3 models. Thus, the changes could be attributed to the action of T lymphocytes, irrespective of whether the target antigen was intrinsic to the joint.
High levels of in vitro igm rheumatoid factor synthesis correlate with hla–dr4 in normal individuals
Authors: Olsen Nancy J. , Stastny Peter , Jasin Hugo E. 
Published: February 2007

AbstractThe association between the HLA–DR4 histocompatibility antigen and in vitro synthesis of IgM and IgM rheumatoid factor (IgM‐RF) by blood mononuclear cells was investigated in 35 normal subjects. In vitro cultures of T and B cells were stimulated with pokeweed mitogen, and the secreted IgM‐RF, tetanus antibody, and total IgM protein were measured by solid‐phase radioimmunoassay. In cultures containing unseparated T cells, IgM‐RF production in the DR4+ and DR4–subgroups was not significantly different. However, depletion of OKT8+ cells containing T suppressor cells resulted in significantly higher IgM and IgM‐RF synthesis in the DR4+ subgroup. Moreover, 6 of the 8 highest levels of IgM‐RF were produced by DR4+ individuals, while only 7 of the remaining 27 individuals were DR4+ (P = 0.035). Ratios of secreted IgM‐RF : IgM indicated that there was a relative enrichment for IgM‐RF–specific B cell precursors in DR4+ high responders, although total numbers of circulating B cells were not increased. High responder B cells had high levels of responsiveness when mixed with T helper cells from low responders, whereas low responder B cells consistently produced low responses, even when cocultured with T helper cells from high responder donors. The data suggest that a subset of normal individuals has a pokeweed mitogen–responsive lymphocyte population that contains a B cell subpopulation specific for IgM‐RF synthesis and that this condition is associated with HLA–DR4. In certain individuals who have the DR4 type, there may be a component of a susceptible genetic background, upon which other factors act to induce IgM‐RF synthesis and which may produce clinical manifestations of rheumatoid arthritis.
Peripheral blood and synovial fluid monocyte activation in inflammatory arthritis. ii. low levels of synovial fluid and synovial tissue interferon suggest that γgm‐interferon is not the primary macrophage activating factor
Authors: Firestein Gary S. , Zvaifler Nathan J. 
Published: February 2007

AbstractBecause synovial fluid monocytes (SFM) in patients with inflammatory arthritis bear an activated phenotype (i.e., high expression of HLA–DR and low expression of the monocyte differentiation antigen Mo2), we assessed the role of γ‐interferon (γ‐IFN) in the activation of these cells. Sensitive and specific radioimmunoassays detected only 0.40 ± 0.20 units/ml of γ‐IFN in the SF of patients with rheumatoid arthritis (RA) and 0.61 ± 0.67 units/ml of γ‐IFN in the SF of patients with other forms of chronic inflammatory arthritis. There was no detectable α‐IFN in any SF studied by radioimmumoassay. Bioassays failed to detect nonimmunoreactive IFN. Synovial tissue (ST) explants produced very little γ‐IFN (0.14 ± 0.091 units/ml), and production was not increased by the presence of indomethacin in the cultures or by removal of adherent cells. However, γ‐IFN was produced if ST was cultivated in the presence of phytohemagglutinin. In SF and ST supernatants, γ‐IFN‐mediated induction of HLA–DR on monocytes was inhibited, even though the amount of immunoreactive IFN was not affected. Prostaglandin E2 was shown to be one possible inhibitor. We demonstrated that a factor that induces HLA–DR on some individuals' peripheral blood monocytes, and cannot be neutralized by monoclonal anti–γ‐IFN antibody, is present in SF and ST supernatants. These data suggest that activation of SFM may occur by mechanisms other than γ‐IFN.
Plasma from rheumatoid arthritis patients does not contain abnormally high levels of α2‐macroglobulin–proteinase complexes
Authors: Davies M. Elisabeth , Coughlan R. , Barrett Alan J. 
Published: February 2007

AbstractWe measured the levels of α2‐macroglobulin (α2M)–proteinase complexes in the plasma of 18 patients with classic rheumatoid arthritis, 11 age‐matched patients with noninflammatory back pain and osteoarthritis, and 8 healthy volunteers. In contrast with previous reports, we found no evidence of α‐proteinase complexes in the plasma samples from individuals in any of the groups. In our assays, all activity that might have been the result of the presence of such complexes in the plasma samples proved instead to be an artifact attributable to contamination of the anti–α2M antibody immobilized on the AffiGel solid phase with a trypsin‐like proteinase. When the contaminating activity was eliminated by pretreatment of the antibody with 1 mM diisopropyl fluorophosphate, no degradation of substrate was detected with any of the plasma samples. However, the ability of the solid‐phase assay to detect and quantitate α2M‐proteinase complexes when they are present was confirmed in control experiments with plasma samples to which preformed α2M‐trypsin complexes had been added, or in which α2M‐kallikrein complexes had been generated by activation of Hageman factor (coagulation factor XII). We therefore conclude that neither normal plasma nor that from rheumatoid arthritis patients contains measurable amounts of α2M‐proteinase complexes.
A low molecular weight, heat‐labile factor enhances neutrophil fc receptor–mediated lysosomal enzyme release and phagocytosis
Authors: Blackburn Warren D. , Heck Louis W. , Koopman William J. , Gresham Hattie D. 
Published: February 2007

AbstractWhen exposed to solid‐phase immune complexes, polymorphonuclear neutrophils (PMN) degranulate and release proteases capable of degrading the major structural macromolecules of the joint. Evidence indicates that the PMN response to such activators may be modified by factors present at the sites of inflammation. We have evaluated the effects of a low molecular weight factor present in synovial fluid from rheumatoid arthritis (RA) patients on Fc receptor‐mediated PMN degranulation and phagocytosis. Synovial fluid samples from 11 RA patients were studied; 10 of them contained factor(s) which augmented phagocytosis and degranulation mediated through the Fc receptor. This factor(s) alone, however, did not initiate neutrophil degranulation: its MW is less than 10,000 daltons and it is unstable when heated to 56°C. We also examined supernatants that were produced by coculturing adherent human mononuclear cells stimulated by IgG‐coated sheep red blood cells with autologous nonadherent mononuclear cells. A factor(s) with properties similar to those found in the synovial fluids (i.e., heat‐labile at 56°C and capable of augmenting Fc receptor‐mediated degranulation and phagocytosis) was found in the stimulated human mononuclear cell culture supernatants. Filtration studies indicated that the MW of this factor(s) is between 2,000 and 10,000 daltons. No such activity was detected in culture supernatants of unstimulated mononuclear cells. Production of the cytokine was blocked by cycloheximide, indicating that protein synthesis was necessary. This factor(s), by enhancing PMN degranulation, may augment PMN‐mediated tissue destruction in diseases such as RA.
Sudden quadriplegia complicating ossification of the posterior longitudinal ligament and diffuse idiopathic skeletal hyperostosis
Authors: Pouchot Jacques , Watts Craig S. , Esdaile John M. , Hill Ross O. 
Published: February 2007

AbstractThe association of ossification of the posterior longitudinal ligament (OPLL) and diffuse idiopathic skeletal hyperostosis (DISH) has been recently described. It may result in devastating compressive myelopathy. We report a case of quadriplegia complicating OPLL in a patient with DISH. In addition, we present a brief review of the literature on OPLL. This report illustrates the importance of appropriate neurologic and radiologic evaluation of persons with DISH, to help prevent severe neurologic complications.
Effects of psychological therapy on pain behavior of rheumatoid arthritis patients. treatment outcome and six‐month followup
Authors: Bradley Laurence A. , Young Larry D. , Anderson Karen O. , Turner Robert A. , Agudelo Carlos A. , Mcdaniel Lisa K. , Pisko Edward J. , Semble Elliott L. , Morgan Timothy M. 
Published: February 2007

AbstractA randomized clinical trial was performed to evaluate a psychological treatment intervention and a social support program, compared with a control program in which no adjunct treatment was rendered, and their effects upon pain behavior, affect, and disease activity of 53 patients with rheumatoid arthritis. The psychological intervention produced significant reductions in patients' pain behavior and disease activity at posttreatment. Significant reductions were also observed in trait anxiety at posttreatment and 6‐month followup. Relaxation training may have been the most important component of the psychological intervention. The social support program produced a significant reduction in trait anxiety only at posttreatment. This is the first well‐controlled study to demonstrate reduced pain behavior, disease activity, and trait anxiety following psychological treatment.
The “chronic, active epstein‐barr virus infection” syndrome and primary fibromyalgia
Authors: Buchwald Dedra , Goldenberg Don L. , Sullivan John L. , Komaroff Anthony L. 
Published: February 2007

AbstractFifty patients with primary fibromyalgia who had been followed in an academic rheumatology practice frequently reported symptoms thought to be typical of “chronic Epstein‐Barr virus infection,” but not of fibromyalgia: recurrent sore throat (54%), recurrent rash (47%), chronic cough (40%), recurrent adenopathy (33%), and recurrent low‐grade fevers (28%). In 55% of the patients, illness had begun suddenly, with what seemed to be a viral syndrome. Antibody titers to Epstein‐Barr virus in the patients with fibromyalgia, however, were not significantly different from those in age‐ and sex‐matched “healthy” and “unhealthy” control subjects.
Arthritis in hereditary hemochromatosis
Authors: Mathews Jeffrey L. , Williams H. James 
Published: February 2007

AbstractSeven pedigrees with 45 members were evaluated for arthropathy associated with hereditary hemochromatosis (HC). Patients with symptomatic extraarticular disease were compared with asymptomatic patients who had evidence of HC on laboratory findings, and with normal subjects. Patients who were homozygous for HC were compared with heterozygous patients and normal subjects. HC arthritis does not appear to be an early predictor of disease, and chondrocalcinosis is a late manifestation of HC arthropathy.
An unusual syndrome of a devastating noninflammatory vasculopathy associated with anticardiolipin antibodies: report of two cases
Authors: Ingram Shirley B. , Goodnight Jr. Scott H. , Bennett Robert M. 
Published: February 2007

AbstractWe describe 2 patients with marked elevations of anticardiolipin antibodies who developed multiple‐organ disease characterized by a noninflammatory vasculopathy. Their cases were remarkable for the fulminant nature of their thrombotic diathesis, which was heralded by a prominent livedo reticularis of the extremities. Both patients had a serologic profile and salivary gland biopsy findings that were consistent with a diagnosis of primary Sjögren's syndrome.
A comparison of changes seen on radiographs of rheumatoid arthritis patients in australia and in china
Authors: Moran Helen , Chen Shun‐Le , Muirden Kenneth D. , Jiang Shao‐Ji , Gu Yue‐Ying , Hopper John , Jiang Pei‐Lin , Lawler Gary , Bai Mark Xu Jung 
Published: February 2007

AbstractTo test the hypothesis that rheumatoid arthritis in patients in China is milder in severity than that in patients in a western country, a comparison was made of 2 series of consecutive outpatients with definite or classic rheumatoid arthritis who were attending referral centers in Melbourne, Australia and Shanghai, China. This paper reports the findings on radiographs of the wrists and hands. Making allowances for age and duration of disease, changes were more frequent and severe in the Australian patient series, particularly at the meta‐carpophalangeal joints.
Idiopathic periosteal hyperostosis with dysproteinemia (goldbloom's syndrome): case report and review of the literature
Authors: Cameron Bonnie J. , Laxer Ronald M. , Wilmot Dan M. , Greenberg Mark L. , Stein Leonard D. 
Published: February 2007

AbstractIdiopathic subperiosteal new bone formation is uncommon in childhood. We report a case of diffuse periostitis in association with hypergammaglobulinemia and hypoalbuminemia in a 12‐year‐old boy. In 1966, 2 cases of idiopathic periosteal hyperostosis with accompanying dysproteinemia were documented. This report serves as a review of this unique and perplexing problem in clinical diagnosis.