bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tri‐Metallic Catalyst for Oxygen Evolution Reaction Enables Continuous Operation of Anion Exchange Membrane Electrolyzer at 1A cm−2 for Hundreds of Hours
Authors: Abdelhafiz Ali , Mohammed Mona H. , Abed Jehad , Lee Dong‐Chan , Chen Mengjie , Helal Ahmed S. , Ren Zhichu , Alamgir Faisal , Sargent Edward , Kohl Paul A. , Elsaidi Sameh K. , Li Ju 
Published: March 2024

AbstractAlthough numerous efforts are made to synthesize active electrocatalysts for green hydrogen production; catalyst stability, and facile synthesis to scale up the production are still challenging. Herein, the production of novel non‐PGM catalysts for the oxygen reduction reaction (OER) in an alkaline aqueous medium is reported, which is based on the synthesis of a trimetallic metal–organic framework (MOF) precursors. Fine‐tuning of the composition of the metal centers (Ni, Co, and Fe) shows a great effect on OER activity after the MOF undergoes dynamic chemical and structural transformations under OER conditions. In situ characterization reveals the origin of OER activity enhancement as metals’ oxidation state increases, inducing compressive mechanical strain on metal centers, enhancing the electronic conductivity through the formation of oxygen vacancies, and stronger metal–oxygen covalency. Catalysts are used in membrane electrode assembly (MEA) setup within an industrial full‐cell anion exchange membrane electrolyzer (AEMEC), showing a stable performance for 550 h without noticeable decay at 750 and 1000 mA cm−2 industrial level current densities.
Light‐induced Delivery of Charged Species using Ion‐selective Core–Shell Nanoparticles
Authors: la Asunción‐Nadal Víctor de , Crespo Gastón A. , Cuartero María 
Published: March 2024

AbstractControlled release systems have gained considerable attention owing to their potential to deliver molecules, including ions and drugs, in a customized manner. We present a light‐induced ion‐transfer platform consisting of a dispersion of nanoparticles (NPs, ~300 nm) with the conductive polymer poly(3‐octylthiophene‐2,5‐diyl) (POT) in the core and a potassium (K+)‐selective membrane in the shell. Owing to the photoactive nature of POT, POT NPs can be used for a dual purpose: as a host for positively charged species and as an actuator to trigger the subsequent release. POT0 and doped POT+ coexist in the core, allowing K+ encapsulation in the shell. As POT0 is photo‐oxidized to POT+, K+ is released to the (aqueous) dispersion phase to preserve the neutrality of the NPs. This process is reversible and can be simultaneously assessed using the native fluorescence of POT0 and via potentiometric measurements. The NP structure and its mechanism of action were thoroughly studied with a series of control experiments and complementary techniques. Understanding the NP and its surrounding interactions will pave the way for other nanostructured systems, facilitating sophisticated applications. The delivery of ionic drugs and interference/pollutant catching for advanced sensing/restoration will be considered in future research.
Dual‐Strategy Tailoring Molecular Structures of Dopant‐Free Hole Transport Materials for Efficient and Stable Perovskite Solar Cells
Authors: Xie Gang , Wang Jing , Yin Shungao , Liang Aihui , Wang Wei , Chen Ziming , Feng Chuizheng , Yu Jianxin , Liao Xunfan , Fu Yuang , Xue Qifan , Min Yonggang , Lu Xinhui , Chen Yiwang 
Published: March 2024

AbstractDopant‐free hole transport materials (HTMs) are ideal materials for highly efficient and stable n‐i‐p perovskite solar cells (PSCs), but most current design strategies for tailoring the molecular structures of HTMs are limited to single strategy. Herein, four HTMs based on dithienothiophenepyrrole (DTTP) core are devised through dual‐strategy methods combining conjugate engineering and side chain engineering. DTTP‐ThSO with ester alkyl chain that can form six‐membered ring by the S⋅⋅⋅O noncovalent conformation lock with thiophene in the backbone shows good planarity, high‐quality film, matching energy level and high hole mobility, as well as strong defect passivation ability. Consequently, a remarkable power conversion efficiency (PCE) of 23.3 % with a nice long‐term stability is achieved by dopant‐free DTTP‐ThSO‐based PSCs, representing one of the highest values for un‐doped organic HTMs based PSCs. Especially, the fill factor (FF) of 82.3 % is the highest value for dopant‐free small molecular HTMs‐based n‐i‐p PSCs to date. Moreover, DTTP‐ThSO‐based devices have achieved an excellent PCE of 20.9 % in large‐area (1.01 cm2) devices. This work clearly elucidates the structure‐performance relationships of HTMs and offers a practical dual‐strategy approach to designing dopant‐free HTMs for high‐performance PSCs.
New Schiff's base derivative and their nano‐sized Cr (III), Fe (III), Ru (III), and Ir (III) complexes: Preparation, DFT, characterization, bio‐catalytic, DNA interactions, cytotoxicity, and docking studies
Authors: Almashnowi Majed Y. A. , Alamier Waleed M. , Alaghaz Abdel‐Nasser M. A. , Ibrahim Diaa A. 
Published: March 2024

Nano‐sized trivalent metal complexes of Cr (III), Fe (III), Ru (III), and Ir (III) were synthesized and characterized of the form [M (FMAVIEP)Cl2] where FMAVIEP = ligand (C14H11N2O2) and M = Cr (III), Fe (III), Ru (III), and Ir (III). Several spectral techniques studies were used to assess our trivalent metal complexes. The trivalent metal complexes' XRD results revealed sharp and intense diffraction peaks, signifying their crystalline properties at nanoscale particle size. Further evidence was obtained from images captured through techniques such as SEM, TEM, energy‐dispersive X‐ray, and AFM. These images confirmed the homogeneous distribution of the trivalent metal complexes over the surface of the complex. DFT studies were used to study the nano‐sized metal (III) complexes via the DFT\B3LYP computational approach, employing a 6–311G* correlation consistent basis set. The energy gap of synthesized complexes was inspected. The obtained data exhibited a strong correlation with the experimental ones, implying the bio‐efficiency of the Ru (III) complex. The absorption measurements for the nano‐sized complexes' interaction with CT‐DNA signify that nano‐sized metal (III) complexes bind through an intercalation mechanism. This conclusion is supported by the observed intrinsic binding constant (Kb) 3.33 × 105–5.84 × 105 M−1.
Metal‐Organic Frameworks‐Derived Nanocarbon Materials and Nanometal Oxides for Photocatalytic Applications
Authors: Ye Jun‐Qing , Xu Shu‐Ying , Liang Qian , Dai Yan‐Zi , He Ming‐Yang 
Published: March 2024

AbstractHarnessing low‐density solar energy and converting it into high‐density chemical energy through photocatalysis has emerged as a promising avenue for the production of chemicals and remediation of environmental pollution, which contributes to alleviating the overreliance on fossil fuels. In recent years, metal‐organic frameworks (MOFs) have gained widespread application in the field of photocatalysis due to their photostability, tunable structures, and responsiveness in the visible light range. However, most MOFs exhibit relatively low response to light, limiting their practical applications. MOFs‐derived nanomaterials not only retain the inherent advantages of pristine MOFs but also show enhanced light adsorption and responsiveness. This review categorizes and summarizes MOFs‐derived nanomaterials, including nanocarbons and nanometal oxides, providing representative examples for the synthetic strategies of each category. Subsequently, the recent research progress on MOFs‐derived materials in photocatalytic applications are systematically introduced, specifically in the areas of photocatalytic water splitting to H2, photocatalytic CO2 reduction, and photocatalytic water treatment. The corresponding mechanisms involved in each photocatalytic reaction are elaborated in detail. Finally, the review discusses the challenges and further directions faced by MOFs‐derived nanomaterials in the field of photocatalysis, highlighting their potential role in advancing sustainable energy production and environmental remediation.
Combination MEG3 lncRNA and Ciprofloxacin dramatically decreases cell migration and viability as well as induces apoptosis in GC cells in vitro
Authors: Najafi Dena , Siri Goli , Sadri Maryam , Yazdani Omid , Esbati Romina , Karimi Parvin , Keshavarz Ali , Mehmandar‐Oskuie Amirreza , Ilktac Mehmet 
Published: March 2024

AbstractGastric cancer (GC) is a prominent cause of cancer‐related mortality worldwide. Long noncoding RNA (lncRNA) maternal expression gene3 (MEG3) participates in numerous signaling pathways by targeting the miRNA‐mRNA axis. Studies on human tumors have demonstrated that the antibiotic Ciprofloxacin induces cell cycle changes, programmed cell death, and growth suppression. In this study, we transfected MEG3 lncRNA and Ciprofloxacin into the MKN‐45 GC cell line. qRT‐PCR was employed to evaluate the effects on the specific microRNA and mRNA. The wound healing test, MTT assay, and flow cytometry were used to assess the impact of their administration on cell migration, viability, and apoptosis, respectively. Research showed that miR‐147 expression fell even more after MEG3 lncRNA transfection, leading to an increase in B‐cell lymphoma 2 (BCL‐2) levels. Ciprofloxacin transfection did not significantly affect the axis, except for MEG3, which led to its slight upregulation. MEG3 lncRNA inhibited the migration of MKN‐45 cells compared to the control group. When MEG3 lncRNA was coupled with Ciprofloxacin, there was a significant reduction in cell migration compared to untreated groups and controls. MTT assay and flow cytometry demonstrated that MEG3 lncRNA decreased cell viability and triggered apoptosis. Simultaneous administration of MEG3 lncRNA and Ciprofloxacin revealed a significant reduction in cell viability caused by increased apoptosis obtained from MTT or flow cytometry assays. Modulating the miR‐147‐BCL‐2 axis decreases cell migration and survival while promoting cell death. In conclusion, combining MEG3 lncRNA with Ciprofloxacin may be an effective therapeutic approach for GC treatment by influencing the miR‐14‐BCl‐2 axis, resulting in reduced cell viability, migration, and increased apoptosis.
Serum metabolomics analysis combined with network pharmacology reveals possible mechanisms of postoperative cognitive dysfunction in the treatment of Mongolian medicine Eerdun Wurile basic formula
Authors: Li Yan , Wang Jiaxin , Qiao Yun , Li Huiru , Wang Zhe , Tian Mengke , Che Limuge , Du Yiri 
Published: March 2024

AbstractThis study analyzed the endogenous metabolites and metabolic pathways in the serum of Sprague–Dawley (SD) rats gavaged with the Eerdun Wurile basic formula (EWB) using metabolomics methods and network pharmacology to explore the possible mechanism of action of the EWB in improving postoperative cognitive dysfunction (POCD). SD rats were divided into the basic formula group, which received the EWB, and the control group, which received equal amounts of distilled water. The blood was collected from the abdominal aorta and analyzed for metabolite profiles using ultra‐high‐performance liquid chromatography–mass spectrometry (UHPLC–MS). Network pharmacology predicts the targets of the differential metabolites and disease targets; takes the intersection and constructs a “metabolite‐disease‐target” network; and performs protein–protein interaction, Gene Ontology, and Kyoto Encyclopedia of Genes and Genomes analyses. A total of 56 metabolites were selected for significant differences between the groups, mainly affecting amphetamine addiction, alcoholism, and regulation of lipolysis in adipocytes. A total of 177 potential targets for differential metabolite action in POCD were selected. The PI3K‐Akt pathway, the HIF‐1 pathway, and the FoxO pathway were in key positions. The studies have shown that EWB could improve POCD through multicomponents, multitargets, and multipathways, providing new possibilities and reference values for the treatment of POCD.
Exploring contemporary challenges and prospective solutions for women's empowerment: Does women's empowerment impact achieving sustainable development goal five?
Authors: Hossain Md. Shahadat , Hosen Mosharrof , Pek Chuen‐Khee , Loh Yue Fang 
Published: March 2024

AbstractExisting literature on women's empowerment (aligned with SDG 5) overlooks the diverse experiences and obstacles faced by women from various racial, ethnic, and socioeconomic backgrounds. This lack of intersectionality within women's empowerment studies hinders our understanding of the unique challenges encountered by marginalized women and limits the effectiveness of policies and interventions aimed at fostering their empowerment. To address this gap, this study delves into the challenges and processes of empowering women in Bangladesh. Qualitative data were gathered through semi‐structured interviews with 12 working women. Thematic analysis of the qualitative data revealed that women face numerous challenges, including lack of education, family support, and economic freedom, as well as complicated processes to access government support and adapt to technological changes. Furthermore, the study identified several potential processes for empowering women, including free education, and training, government support, awareness development, technological support, and mentorship. The study concludes with discussions, policy implications, limitations, and future research directions.
Toward sustainable automobility: Insights from a stewardship literature review of the industry
Authors: Dodd Tracey , Cheong Chee Seng , Hoffmann Arvid , Zurbruegg Ralf 
Published: March 2024

AbstractThe automotive industry is actively pursuing a course of sustainable development; however, to date, progress has been limited. This is because a truly sustainable future requires a substantial and transformative approach to automobility. Some scholars argue that this transformative approach might be found by exploring an industry transition based on stewardship rather than the current status quo of incremental change. Hence, as a way of offering new insights to stimulate action for sustainability, this study presents the first comprehensive review of stewardship in the automotive sector. From an analysis of 161 peer‐reviewed articles published between 1990 and 2022, we identified two underconceptualized forms of stewardship—environmental and social—both of which have an interconnected relationship. Environmental stewardship involves actions that address ecological challenges, while social stewardship pertains to broader, positive impacts on communities. We argue that understanding the interplay between these different forms of stewardship is crucial for achieving comprehensive sustainability outcomes. Additionally, this research identifies gaps in the literature and outlines areas for future research to help both managers and society navigate the complex sustainability issues facing the automotive industry.
A Comprehensive Examination of Heterocyclic Scaffold Chemistry for Antitubercular Activity
Authors: Bendi Anjaneyulu , Yadav Priyanka , Saini Komal , Singh Bhathiwal Anirudh , Raghav Neera 
Published: March 2024

AbstractTuberculosis is a communicable disease which affects humans particularly the lungs and is transmitted mainly through air. Despite two decades of intensive research aimed at understanding and combating tuberculosis, persistent biological uncertainties continue to hinder progress. Nowadays, heterocyclic compounds have proven themselves in effective treatment of tuberculosis because of their wide range of biological and pharmacological activities. Antituberculosis or antimycobacterial agents encompass a broad array of compounds utilized singly or in conjunction to combat Mycobacterium infections, spanning from tuberculosis to leprosy. Here, we summarize the synthesis of various heterocyclic compounds which includes the greener synthetic route as well as use of nano compounds as catalyst along with their anti TB activities.
Influence of electrical polarization on thrombogenicity of titania nanotubes
Authors: Muralidhar Jyorthana Rajappa , Sakthivel Kabilan , Sridharan Madanagurusamy , Kikuchi Masanori 
Published: March 2024

AbstractThe development of hemocompatible biomaterials with antithrombogenic surface coatings remains a challenge in cardiovascular applications. There is interest in negatively charged surfaces that inhibit thrombus formation through electrostatic repulsion between the biomaterial surface and negatively charged platelets. Hence, the present study investigated the influence of electrical polarization on the thrombogenicity of titania nanotubes (TNT), which are promising candidates for inhibiting thrombogenicity via surface modification. TNTs were formed on commercially pure titanium plate by the electrochemical anodization technique using platinum as a counter electrode at 60 V for 24 h with two kinds of electrolytes (hydrofluoric acid diluted with dimethyl sulfoxide [D‐TNT] or ethylene glycol [E‐TNT]) followed by an annealing at 540°C for 3 h in air. Both TNTs were mixture of anatase and rutile, and the D‐TNT had a diameter of 108.76 ± 2.55 nm and the E‐TNT, 53.833 ± 2.42 nm. The TNTs were electrically polarized at 100 V of DC field and 400°C for 1 h. Water contact angle measurements showed that the non‐polarized (0‐) TNT surface was hydrophilic whereas the positively (P‐) or negatively (N‐) polarized TNT surfaces showed high‐hydrophilicity. Antithrombogenicity was evaluated using the thrombus coverage area ratio (TCAR) after soaking the TNTs in bovine whole blood. The TCARs for 0‐polarized E‐ and D‐TNTs were 5.30 ± 4.34% and 36.3 ± 5.8% and for P‐polarized E‐TNT and D‐TNT were 1.50 ± 0.77% and 2.76 ± 1.07%, whereas no thrombus formation (0 ± 0%) for N‐polarized E‐TNT and very few thrombus formation (0.12 ± 0.22%) for N‐polarized D‐TNT. The electrostatic repulsion between the N‐polarized E‐TNTs and platelets completely inhibits thrombus formation, which cannot be achieved by the nanomorphology and high‐hydrophilicity of other TNTs. Hence, N‐TNTs formed by electrical polarization are potential candidates for cardiovascular devices, such as artificial heart valves with long‐term hemocompatibility.
Comparison of Measurements for Enhanced Diffusion Problem in Chemical Reaction Systems
Authors: Jee Ah‐Young , Wen Ziyang , Wang Huan 
Published: March 2024

Comprehensive SummaryThe problem of molecular diffusion in the soup of chemical reactions attracts mounting interest across fields ranging from chemistry to biophysics to material science. Chemical reactions involve bond breakup and formation, whose time scale is typically on the orders of fs to ps, while molecular diffusion occurs at time scales of μs to ms. The two processes are often considered orthogonal, given the vastly different scales. The serial results show that the enzyme's diffusion is enhanced in a substrate‐dependent manner, which was further extended to small molecule reaction systems, challenging this classical paradigm. However, the results from different groups using different techniques do not quantitatively agree, and a general mechanism is yet to be understood. We summarize experimental studies on diffusion problems and seek to reconcile the interpretation with understanding the limits of measurement tools and the chemical nature of reaction systems. Understanding molecular diffusion in chemical reactions will provide fresh thoughts in designing chemical systems such as molecular machines that harvest work at the nanoscale in a controllable manner.
Hatching plasticity is associated with a more advanced stage at hatching in an Ambystoma with terrestrial eggs
Authors: Treadaway Kimberly D. , Hale Rebecca E. 
Published: March 2024

AbstractHatching plasticity allows animals to initiate hatching in response to environmental cues including predation, flooding, and hypoxia. In species with terrestrial eggs but aquatic larvae, hatching plasticity often manifests as extended development of embryos when water is not available. Although these effects are taxonomically widespread, little attention has focused on differences in plasticity across closely related species with terrestrial and aquatic embryos. We propose that the terrestrial embryonic environment favors slower and prolonged development and, consequently, that we should see differences in development between closely related species that differ in where they lay their eggs. We test this hypothesis by comparing embryonic development between two mole salamanders, Ambystoma opacum and A. annulatum. Most Ambystoma lay eggs submerged in ponds but A. opacum lays its eggs on land, where hatching is triggered when eggs are submerged by rising pond levels. Embryos of both species were reared under common laboratory conditions simulating both aquatic and terrestrial nest sites. Consistent with our hypothesis, we found that A. opacum embryos exhibited slower development and took longer to hatch than A. annulatum embryos in both rearing environments. Furthermore, we observed in A. opacum a plasticity in hatching stage that was absent in A. annulatum. Our results indicate that the terrestrial‐laying A. opacum has evolved slower and prolonged development relative to its aquatic‐laying congener and suggest that embryonic survival in the unpredictable terrestrial environment may be facilitated by developmental plasticity.
Assessing the impact of haemodynamic monitoring with CardioMEMS on heart failure patients: a cost–benefit analysis
Authors: Codina Pau , Vicente Gómez José Ángel , Hernández Guillamet Guillem , Ricou Ríos Laura , Carrete Andrea , Vilalta Victoria , Estrada Oriol , Ara Jordi , Lupón Josep , Bayés‐Genís Antoni , López Seguí Francesc 
Published: March 2024

AbstractAimsThe objective of this study was to perform a cost–benefit analysis of the CardioMEMS HF System (Abbott Laboratories, Abbott Park, IL, USA) in a heart failure (HF) clinic in Spain by evaluating the real‐time remote monitoring of pulmonary artery pressures, which has been shown to reduce HF‐related hospitalizations and improve the quality of life for selected HF patients. Particularly, the study aimed to determine the value of CardioMEMS in Southern Europe, where healthcare costs are significantly lower and its effectiveness remains uncertain.Methods and resultsThis single‐centre study enrolled all consecutive HF patients (N = 43) who had been implanted with a pulmonary artery pressure sensor (CardioMEMS HF System); 48.8% were females, aged 75.5 ± 7.0 years, with both reduced and preserved left ventricular ejection fraction; 67.4% of them were in New York Heart Association Class III. The number of HF hospitalizations in the year before and the year after the sensor implantation was compared. Quality‐adjusted life years gained based on a literature review of previous studies were calculated. The rate of HF hospitalizations was significantly lower at 1 year compared with the year before CardioMEMS implantation (0.25 vs. 1.10 events/patient‐year, hazard ratio 0.22, P = 0.001). At the end of the first year, the usual management outperformed the CardioMEMS HF System. By the end of the second year, the CardioMEMS system is estimated to reduce costs compared with usual management (net benefits of €346).ConclusionsBased on the results, we suggest that remote monitoring of pulmonary artery pressure with the CardioMEMS HF System represents a midterm and long‐term efficient strategy in a healthcare setting in Southern Europe.