bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reconstruction of the lower lip
Authors: Wilson J. S. P. , Walker E. P. 
Published: February 2007

AbstractCarcinoma of the lip arises in the strip of exposed mucosa between the mucocutaneous junction and the point of contact of the lips. Removal of the entire area at risk usually prevents recurrence or the development of a second primary tumor. A classification of lower lip involvement is presented, the various modes of treatment are reviewed, and surgical techniques for providing a pouting lower lip vermilion are described.
Combination chemotherapy for advanced squamous cell carcinoma of the head and neck
Authors: Coker Donald D. , Elias E. George , Chretien Paul B. , Gray William C. , Coleman John J. , Zentai Theresa A. , Didolkar Mukund S. , Morris Don M. , Viravathana Thavinsakdi , Hebel John R. 
Published: February 2007

AbstractFifty‐one patients (32 previously untreated, 19 previously treated) with advanced squamous cell carcinoma of the head and neck received a single course of combination chemotherapy consisting of high dose cis‐platinum (DDP), bleomycin (Bleo), ± high dose methotrexate (MTX). Thirty‐three (65%) patients responded to therapy; 5 (10%) of these patients had a complete response. Previously untreated patients and those who received the three drugs (DDP, Bleo and MTX) had the highest response rates. The duration of response was 8 to 12 weeks. Seven (15%) patients showed a two‐year survival rate. All nonresponders were dead of disease within two years. Three (56%) of the five complete‐response patients and 4 (21%) of the partial‐response patients survived for two years. The role of preoperative chemotherapy in head and neck cancer is yet to be conclusively defined.
Nuclear medicine in diagnosis and treatment of diseases of the head and neck: II
Authors: Blahd William H. , Rose Judith G. 
Published: February 2007

AbstractThe advent of both improved imaging systems and new radioactive agents has increased the effectiveness of nuclear medicine in diagnosing and treating diseases of the head and neck. In this second of two articles, we discuss radionuclide bone imaging and the role of nuclear medicine in the management of thyroid disease. Radionuclide bone imaging is useful in the differential diagnosis of sinusitis, the early detection of head and neck fracture, the assessment of temporomandibular joint disease, and the identification of local extension of primary head and neck carcinoma. In the management of thyroid disease, radionuclide technology is uniquely helpful in the diagnostic evaluation of the thyroid nodule and radioactive iodine continues to play a major role in thyroid cancer therapy.
Osteosarcoma of the nasal bone in a child
Authors: Singh Jagdev , Gluckman Jack L. , Kaufman Robert A. , Wakely Paul E. 
Published: February 2007

AbstractOsteosarcoma commonly arises in the metaphyses of the long bones and rarely appears in other parts of the long bones or in flat bones. In the head and neck, 6.5% of all osteosarcomas occur in the jaws. A very rare case is presented in which an osteosarcoma developed in the nasal bones of a 4‐year 9‐month‐old girl without any predisposing cause. The literature pertaining to osteosarcomas of the head and neck, particularly in children, also is reviewed.
Paranasal sinus radiology, Part IA: Introduction and the frontal sinuses
Authors: Dolan Kenneth D. 
Published: February 2007

AbstractThe radiologic techniques of plain film roentgenography, tomography, and computerized tomography are important supplements to patient history and physical examination in the diagnosis of diseases of the paranasal sinuses. Background historical information regarding these radiologic modalities is presented, and the development and anatomy of the sinuses and roentgenographic views are discussed. The development and anatomy of the frontal sinuses are discussed, and inflammatory disease of the frontal sinuses as it appears in various roentgenographic modalities is described and illustrated.
Paranasal sinus radiology, part 2B: Ethmoidal sinuses
Authors: Dolan Kenneth D. 
Published: February 2007

AbstractThe clinician must have a high level of suspicion in order to detect ethmoidal sinus disease. Survey plain film radiographic examination may provide information about gross changes in ethmoidal sinus transparency and the sinus walls. Conventional tomographic study will often aid evaluation of the ethmoidal sinus walls which may be obscured by overlying structures on plain films. Computerized tomography adds a new dimension to ethmoidal sinus study. By revealing not only bone changes but soft‐tissue abnormality as well, more complete understanding of the disease process is gained. Computerized tomography is particularly useful in evaluating orbital structural change due to ethmoidal sinus abnormality.
Olfactory neuroblastoma: A retrospective clinicopathologic study
Authors: Appelblatt Nancy Haley , McClatchey Kenneth D. 
Published: February 2007

AbstractTwenty‐one cases of olfactory neuroblastoma treated at The University of Michigan Hospitals between 1945 and 1981 were reviewed with emphasis on the method of treatment and outcome. Staging of the cases by the method of Kadish and co‐workers was done. The clinical course was not predictable on the basis of the histologic criteria. Local recurrences were common (61%). Metastatic spread of the neoplasms occurred in 28% of the cases. The recurrence‐free interval decreased in those patients treated initially with radiation as compared with those treated with surgery alone. This study does not support the premise that radiation treatment is as good as surgery in early disease. Craniofacial resection combined with radiation treatment for recurrence is the preferred treatment.
Paranasal sinus radiology, part 3A: Sphenoidal sinus
Authors: Dolan Kenneth D. 
Published: February 2007

AbstractThis article describes the complex anatomy of the sphenoid bone. The development and size of the sphenoidal sinuses are quite variable and complete analysis of the sinus walls requires several views. The essential plain film projections and use of tomography and CT scans are described. Sphenoidal sinus inflammatory disease produces changes similar to those already discussed in the articles in this series on the frontal sinus and the ethmoidal sinus. Illustrations of sphenoidal sinus inflammatory disease are provided.
Rapid percutaneous cervical esophagostomy
Authors: Macht Steven D. , Fisher Jack 
Published: February 2007

AbstractOur technique of percutaneously inserting a No. 16 gauge long Bard Angiocath when performing a cervical esophagostomy is described. This has been a safe and rapid technique, and its only disadvantage is the inability to adequately suction the stomach immediately after the procedure.
The management of hemangiomas of the eyelid and orbit
Authors: Pasyk Krystyna A. , Dingman Reed O. , Argenta Louis C. , Sandall Gary S. 
Published: February 2007

AbstractThe growth of hemangiomas of the orbital region varies greatly; it is unpredictable. Most lesions never reach sufficient size to impair vision; a few, however, may grow sufficiently to cause disastrous complications. Nine children with complete or partial occlusion of the vision by hemangioma of one eye are reported. (Functional vision was preserved only in those patients who had early subtotal excision of the eyelid hemangioma.) Two children with complete occlusion developed amblyopia in the involved eye. One had optic nerve atrophy. One of the four children with partial occlusion of vision had a permanent decrease in visual acuity. Of the remaining three children with normal vision, two had been operatively treated early, and one had unusually rapid involution of the hemangioma. We recommend that when a child has complete or partial visual occlusion due to hemangioma, subtotal or total excision of the hemangioma should be carried out within 1 week of the onset of visual occlusion to prevent amblyopia.
A new instrument: The goiter extractor
Authors: Sacre Robert 
Published: February 2007

AbstractIn order to simplify the extraction of large intrathoracic goiters and to avoid dramatic surgical problems, the author developed a simple instrument to extract goitric masses. The extractor was used 17 times (approximately 10% of the thyroidectomy procedures performed during 3 years). Its effectiveness was proven in 16 cases.
A study of whole organ cancerous larynges to determine resectability by conservation surgery
Authors: Robbins K. Thomas , Michaels Leslie 
Published: February 2007

AbstractSixty‐two extirpated whole larynges containing squamous cell carcinoma were examined by a transverse slicing method to determine whether a partial laryngeal resection would have been feasible. The epithelial origin and sites of invasion of each tumor were recorded. The observations suggested that in one third of the specimens conservation laryngeal surgery could have achieved complete removal of the cancer.
Permanent tracheostomy
Authors: Eliachar Isaac , Zohar Shmuel , Golz Avishai , Joachims Henry‐Zvi , Goldsher Moshe 
Published: February 2007

AbstractA technique designed to create a permanent, wide open, and stable tracheal stoma is based on two corresponding U‐shaped flaps: one from the anterior tracheal wall, the other from the skin in the suprasternal notch. The method described in this article has proved to be efficient, practical, well tolerated, and readily reversible. Its applications when indicated may reduce the side effects and complications associated with tracheostomy. Our clinical experience with this technique covers eight patients who tolerated the procedure well. The follow‐up period exceeds 2 years.
Internal jugular phlebectasia
Authors: Matsuba Howard M. , Thawley Stanley E. , Smith Peter G. 
Published: February 2007

AbstractInternal jugular phlebectasia or abnormal fusiform dilatation of the jugular venous system usually presents as a neck mass that increases in size with maneuvers, which increase intrathoracic pressure. We present a case of internal jugular phlebectasia in which, due to an atypical presentation, the diagnosis was confirmed only by surgical exploration. The pathophysiology and radiologic evaluation are discussed to determine the role reserved for surgery in the management of this entity.
Pain in the head and neck cancer patient: Changes over treatment
Authors: Keefe Francis J. , Manuel Gerdenio , Brantley Alton , Crisson James 
Published: February 2007

AbstractThe incidence, severity, and location of pain was evaluated in 30 head and neck cancer patients prior to treatment after the first phase of their treatment and upon the completion of treatment. The incidence of pain was relatively high (40%–70%) and tended to increase slightly over treatment. Patients having advanced disease (stage III or IV) had a higher incidence of pain. Pain severity ratings were stable over treatment. Pain was located close to tumor or incision sites, and a trend for patients to report a greater number of pain sites over treatment was noted. While medical status variables (disease stage and site) were found to predict pain status after the initial phase of cancer treatment, initial pain measurements were more likely to predict pain status at the completion of treatment.
Total Synthesis of a Natural Cerebroside from Euphorbiaceae
Authors: Cateni Francesca , Zacchigna Marina , Zilic Jelena , Di Luca Gabriella 
Published: February 2007

AbstractThe regioselective total synthesis of the natural cerebroside (2R,15Z)‐N‐{(1S,2S,3R,4R,5Z)‐1‐[(β‐D‐glucopyranosyloxy)methyl]‐2,3,4‐trihydroxyheptadec‐5‐en‐1‐yl}‐2‐hydroxytetracos‐15‐enamide (2), originally isolated from Euphorbiaceae, is reported in full detail.
Chemotherapy as definitive treatment of stage I‐II large cell and diffuse mixed lymphomas
Authors: Cabanillas Fernando 
Published: February 2007

AbstractCombination chemotherapy with adriamycin‐containing regimens is effective in the management of advanced lymphomas. In view of this, we treated 43 patients with clinical stage I‐II large cell or diffuse mixed lymphoma with chemotherapy. Routine staging laparotomies were not done and radiotherapy was not used in these patients. The CR rate for the combined stage I‐II presentations is 90%. Of 11 patients with stage I presentations, only one has relapsed (at 64 months), and he expired 11 months after the recurrence. Of the 28 patients with stage II presentations who achieved a CR, seven have relapsed but three of these have achieved a second CR and remain in remission. Late relapses were common in this group of stage I‐II presentations. Four of eight relapses occurring in patients who achieved disease‐free status took place > 24 months after initiation of therapy. Chemotherapy alone appears to be adequate for treatment of stage I large cell lymphoma, although larger numbers of patients might be required to definitely make this conclusion. Close to 2/3 of patients with stage II presentations appear to have been cured with the use of chemotherapy alone. The failures occurred mostly in those with bulky disease. It is possible that radiotherapy given after chemotherapy could consolidate these bulky areas of disease and thus prevent local relapses.
The role of radiation therapy in the treatment of early stage large cell lymphoma
Authors: Levitt Seymour H. , Lee Chung K. K. , Bloomfield Clara D. , Frizzera Glauco 
Published: February 2007

AbstractNineteen patients with localized non‐Hodgkin's lymphoma large cell type classified by the international formulation in group D (5) and group G (14) were treated with extended field radiation therapy. These patients have been followed for 168 months with range from 12 to 168 months from initiation of treatment. In G category of the formulation, the overall survival is 83 per cent at 5 and 10 years and recurrence‐free survival is 75 per cent at 10 years. Sixteen of the patients were stage I and three were stage II. Two patients died without evidence of recurrence. Four patients recurred and two of these died of disease. Thirteen of the 19 patients are alive and recurrence free. Bulk of disease had no apparent influence on the response to irradiation. We believe that the early pathological stage large cell lymphoma of the G and D type international formulation are appropriate candidates for radical radiation therapy and benefit from this approach to treatment.
Bone marrow examination in small cell carcinoma of the bronchus: An unnecessary procedure?
Authors: Mead G. M. , Williams C. J. , Thompson J. , Smith A. G. , Whitehouse J. M. A. 
Published: February 2007

AbstractOne hundred and thirty‐seven patients with small cell carcinoma of the bronchus underwent bone marrow trephine and/or aspirate examination as part of their clinical staging. Twenty‐four patients (17.5 per cent) were found to have malignant marrow infiltration. In no case was this an isolated finding of metastatic disease, indeed most patients had gross metastatic spread to liver and/or bone. Marrow infiltration has not been shown to be a major prognostic factor in response to chemotherapy or survival in previous studies. We recommend that this staging procedure be discontinued in routine clinical practice, and instead be confined to specific indications in clinical trials.
Adenosine deaminase in plasma of patients with adult T‐cell leukemia (ATL): Correlation between enzyme activity and the ATL subtypes
Authors: Oda Tetsuya , Kagimoto Tadashi , Aso Norio , Yamaguchi Kazunari , Tomino Shinhachiro , Takatsuki Kiyoshi 
Published: February 2007

AbstractAdenosine deaminase (ADA) was assayed in plasma from 14 patients with adult T‐cell leukemia (ATL) (eight with acute ATL and six with smoldering or chronic ATL), 20 male family members (ten were anti‐ATLA antibody positive and the other ten negative), and 25 normal individuals. ADA activity was uniformly higher in plasma from patients with ATL than normal controls. This enzyme activity significantly increased in acute ATL in comparison to smoldering or chronic ATL. In families of ATL patients, no statistical difference in ADA activity between the anti‐ATLA antibody‐positive group and ‐negative group could be discerned. The enzyme activity in a patient with acute ATL, after a bone‐marrow transplant, rapidly increased as leukemic cells increased in peripheral blood. These findings indicate that the levels of ADA activities in plasma from ATL patients reflect the condition of this disease. Thus, measurement of this enzyme activity offers a further parameter to distinguish subtypes of ATL, and is of prognostic and therapeutic value.
Characterization of myeloid leukemias with monoclonal antibodies 3C5 and MY9
Authors: Matutes Estela , Rodriguez Bendjhui , Polli Nicoletta , de Castro J. Tavares , Parreira A. , Andrews Carolyn , Griffin J. D. , Tindle R. W. , Catovsky D. 
Published: February 2007

AbstractThe expression of two membrane antigens identified by the monoclonal antibodies (McAb) My9 and 3C5 has been investigated in cells from 80 acute leukemias. My9 was positive in the blasts of 33 out of the 38 (87 per cent) cases of acute myeloid leukemia (AML) tested, regardless of FAB subtype, and in 13 of 18 (72 per cent) cases of chronic granulocytic leukemia (CGL) in myeloid blast crisis. The reactivity of 3C5 was confined to myeloblastic (M1) AML, 85 per cent of cases, and to lymphoblastic leukemia (ALL) of B‐lineage, 70 per cent of cases, including CGL in lymphoid transformation. My9 was negative in ALL except for an unusual case. The phenotype My9+, 3C5+ was seen exclusively in M1 (69 per cent) and M2 (14 per cent) AML. Ultrastructural analysis with the immunogold method in combination with the myeloperoxidase (MPO) reaction showed that expression of My9 increased in parallel with MPO activity whereas 3C5 was expressed mainly in myeloblasts with little MPO content. We conclude that the use of these two McAb will contribute to the diagnosis and classification of AML and may throw some light to the pathogenesis of biphenotypic acute leukemias, including TdT + AML.
Adolescent and adult lymphoblastic leukaemia: Prognostic factors and response to treatment
Authors: Fraser G. G. , Hart D. N. J. , Heaton D. C. , Hamer J. W. , Allen J. , Beard M. E. J. 
Published: February 2007

AbstractThirty consecutive patients with acute lymphoblastic leukaemia (ALL) who received treatment at Christchurch Hospital between 1972 and 1982 were reviewed. Complete remission (CR) was achieved in 80 per cent with a median survival of 65 weeks. Eleven of 30 patients had one or more of the following features—B cell ALL, a mediastinal mass, the Philadelphia chromosome (Ph1) and age 60 years or older at diagnosis. Although CR was obtained in 8 of these patients none survived three years. The remaining 19 patients were regarded as ‘good risk’ and treated by moderate intensity chemotherapy schedules. CR was obtained in 16 of these patients (84 per cent) and the estimated 5 year survival was 62 per cent with 6 patients remaining in remission from 5 to 9 years from diagnosis.These results demonstrate the value of objective and reproducible clinical and laboratory findings in defining a subset of ALL patients which may not require high intensity chemotherapy schedules.
Human t‐cell leukemia virus: Causative roles in development of adult t‐cell leukemia and provirus integration into leukemic cell DNA
Authors: Yoshida M. , Seiki M. 
Published: February 2007

AbstractHuman T‐cell leukemia virus (HTLV) was isolated from a cutaneous T‐cell lymphoma patient by Gallo and his colleagues (Poiesz et al., 1980) and adult T‐cell leukemia virus (ATLV) was isolated from patients with adult T‐cell leukemia (ATL) in Japan (Yoshida et al., 1982). Originally, these two viral isolates were thought to be different since they were isolated from apparently different tumors. However, we have shown that HTLV in the Caribbean and ATLV in Japan are the same virus (Watanabe et al., 1983, 1984) and the patient from which HTLV was isolated was identified as an atypical case of ATL (Bunn et al., 1983).
Malignant lymphomas in Japan: Epidemiological analysis on adult t‐cell leukemia/lymphoma
Authors: Tajima Kazuo , Tominaga Suketami , Suchi Taizan 
Published: February 2007

AbstractAccording to the Vital Statistics Japan Series in 1950–1981, the age‐adjusted death rate for malignant lymphomas (ICDs, 200–202) in Japan has increased in recent years. A geographical clustering of malignant lymphomas in the Kyushu districts was observed both in the period 1969–1971 and more recently in 1979–1981. The excessive rate of malignant lymphomas in Kyushu was due to the high incidence of adult T‐cell leukemia/lymphoma (ATLL). The distribution of healthy carriers of ATLV, a human retrovirus which is almost identical to HTLV, was closely related to that of patients with ATLL in Japan. Epidemiological features of the infectious mode of ATLV suggested two main routes of natural transmission, one from mother to child and the other from husband to wifeATLV is considered to be a main causative agent of ATLL from virological and epidemiological evidence, but infection by this virus alone may not result in ATLL because the incidence of ATLL among ATLV carriers was apparently not very high even in endemic areas of ATLL. Thus, some risk factors other than ATLV, such as environmental and genetic factors, may contribute to the development of ATLL.
lymphoma type adult T‐cell leukemia—a clinicopathologic study of HTLV related T‐cell type malignant lymphoma
Authors: Yamaguchi Kazunari , Yoshioka Ritsuko , Kiyokawa Tetsuyuki , Seiki Motoharu , Yoshida Mitsuaki , Takatsuki Kiyoshi 
Published: February 2007

AbstractThe clinical and pathological features of T‐cell type malignant lymphoma related to human T‐cell leukemia virus (HTLV) were investigated in eight patients presenting lymphadenopathy. Biopsy of lymph nodes showed an histology of diffuse non‐Hodgkin's lymphoma. All patients were positive for anti‐ATLA antibody and HTLV proviral DNA in the lymph node cells. Most patients showed pronounced hypercalcemia and high serum levels of lactic dehydrogenase. All patients died between 3 and 17 months (mean 8 months) after the onset of diseaseHTLV‐related malignant lymphoma should be added to the spectrum of ATL, being classified as a lymphoma type ATL.
The effect of vinblastine on CFU‐E IN normal and W anaemic mice
Authors: Chervinsky David S. , Tebbi Cameron , Williams Douglas , Orsini Frank , Fitzpatrick John , Freeman Arnold I. 
Published: February 2007

AbstractUsing a plasma clot technique, we studied the comparative levels of in vitro erythroid colony forming units (CFU‐E) of normal and W anaemic mice following intravenous (IV) injection of 6·25 mg/kg of vinblastine (VBL). Mice used in this study were C57B1/6J, WBB6F,1, (+/+, WVv/+ and W/Wv). CFU‐E content was looked at on day 0, 1, 3, 5, 7 and 10 following IV VBL. The CFU‐E content of bone marrow (BM) and spleen was adequate prior to VBL treatment in all four mouse strains tested. We found IV VBL resulted in a significant rebound of CFU‐E production in spleens of all four mouse strains. Most CFU‐E production occurred on days 7 and 10 post VBL. The total CFU‐E content of BM was not significantly affected by VBL in C57B1/6J, WBB6F1, +/+ and Wv/+ mice. However, a significant reduction of total CFU‐E was seen in the BM of WBB6F1, W/Wv mice. This plus the fact that increased CFU‐E is seen in the spleen of all mouse strains including W/Wv suggests that there may be differing cellular or environmental factor(s) in different hematological organs controlling CFU‐E of the W/Wv mouse.