bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlates of breast reconstruction
Authors: Morrow Monica , Mujahid Mahasin , Lantz Paula M. , Janz Nancy K. , Fagerlin Angela , Schwartz Kendra , Liu Lihua , Deapen Dennis , Salem Barbara , Lakhani Indu , Katz Steven J. 
Published: October 2005

AbstractBACKGROUNDImmediate or early postmastectomy breast reconstruction is performed infrequently. To the authors' knowledge, little is known regarding surgeon or patient perspectives on reconstruction treatment decisions. The purpose of the current study was to identify patient attitudes and preferences associated with breast reconstruction, and whether these differed by race.METHODSA sample of women age ≤ 79 years who were diagnosed with ductal carcinoma in situ and invasive breast carcinoma between December 2001 and January 2003 was identified from the Surveillance, Epidemiology, and End Results (SEER) registries of Detroit and Los Angeles. Eligible subjects completed a questionnaire at a mean of 7 months after diagnosis. The Wald chi‐square test and logistic regression were used for data analysis.RESULTSOf the 1844 respondents, 646 underwent a mastectomy (35.0% of the total sample) and 245 of these patients received breast reconstruction (38.0%; of the mastectomy group). On multivariate analysis, younger patient age, higher educational levels, and earlier stage of disease were found to be significantly associated with breast reconstruction. Although 78.2% of women reported that breast reconstruction was discussed, only 11.2% correctly answered 3 basic knowledge questions regarding the procedure. The desire to avoid more surgery was the most common reason for not undergoing breast reconstruction.CONCLUSIONSThe results of the current study found that the majority of women were aware of breast reconstruction but choose not to undergo the procedure. Lack of knowledge and a greater perception of barriers to the procedure were more common among African‐American patients and women with a lower education level, suggesting a need for improved educational strategies. Cancer 2005. © 2005 American Cancer Society.
Family physician consultation patterns indicate high risk for early‐onset anorexia nervosa
Authors: Lask Bryan , Bryant‐Waugh Rachel , Wright Fiona , Campbell Mari , Willoughby Kate , Waller Glenn 
Published: October 2005

AbstractObjectiveThere is often a delay in the recognition of early‐onset anorexia nervosa. The current study aimed to determine whether there are specific patterns in the frequency and content of family physician consultations that might predict its onset.MethodLifetime number and type of family physician consultations were recorded for three groups: (a) an index group comprising 19 girls with anorexia nervosa, onset under 14; (b) a clinical control group comprising 19 girls with an emotional disorder; and (c) a nonclinical group comprising 19 girls with no history of mental health problems.ResultsBoth clinical groups had an elevated number of consultations, particularly in the 5 years before diagnosis. The index group had a significantly higher number of eating, weight, and shape consultations (especially in the year before diagnosis), whereas the clinical control group had a greater number of psychological consultations.ConclusionA single consultation about eating behaviour or weight and shape concerns is a strong predictor of the subsequent emergence of anorexia nervosa. © 2005 by Wiley Periodicals, Inc.
Advanced anorexia nervosa, associated with pneumomediastinum, pneumothorax, and soft‐tissue emphysema without Esophageal lesion
Authors: Danzer Gerhard , Mulzer Johanna , Weber Gerrit , Lembke Alexander , Kocalevent Rüya , Klapp Burghard F. 
Published: October 2005

AbstractObjectiveWe describe the case of a 20‐year‐old female patient suffering from anorexia nervosa since the age 15 of years. When admitted, she was 168 cm tall with a weight of 35 kg (body mass index [BMI] = 12.4). A week after admission, the patient complained of retrosternal pain, and a few hours later she developed extensive soft‐tissue emphysema.MethodsThe X‐ray picture of her thorax showed left‐hand supraclavicular and infraclavicular emphysema, extensive emphysema in both sides of the soft tissue of the throat, a left‐hand apical pneumothorax (4 mm), and a pneumomediastinum.ResultsWe discuss the extent to which these symptoms are interrelated in the sense of a causal nexus.ConclusionWe ruled out any other differential‐diagnostic etiopathogenic factors and concluded that the cause of our patient's soft‐tissue emphysema, pneumothorax, and pneumomediastinum might well be autodestructive behavior. © 2005 by Wiley Periodicals, Inc.
Seasonally bound ovopathy versus “temperature at conception” as cause for anorexia nervosa and other eating disorders
Authors: Jongbloet Piet Hein , Groenewoud Hans M.M. , Roeleveld Nel 
Published: October 2005

AbstractObjectiveA preponderance of births between April and June in patients with anorexia nervosa (AN) and other eating disorders (EDs) has recently been explained by a higher environmental temperature at conception. This hypothesis, however, does not explain some other irregularities in the month of birth distribution in contrast to the seasonal preovulatory overripeness ovopathy (SPrOO) and seasonal optimally ripened oocytes (SOptRO) hypotheses.MethodThe month of birth distribution of 408 patients with EDs from Southeast England and of 199 patients from Australia has been reassessed in relation to previously determined high‐risk and low‐risk months based on a priori knowledge from mammals and on the physiologic birth peaks and troughs in humans at population level. The differences between high‐risk and low‐risk months were assessed by conventional chi‐square analyses and by relative risks (RRs) with 95% confidence intervals (CI).ResultsIn England, fewer AN patients (n = 259) were born at the peaks of the total birth pattern, that is, during the 2 low‐risk months, and more were born during the transitional stages, that is, during the remaining 10 high‐risk months (p = .004; RR = 1.66 [95% CI = 1.13–2.41]). After the addition of 149 other ED patients (n = 408), this result remained (p = .005; RR = 1.47 [95% CI = 1.10–1.97]). Similar results were found in 199 ED patients from Australia (p = .009; RR =1.70 [95% CI = 1.09–2.64]).ConclusionED patients appear to be more frequently conceived during the transitional stages of the ovulatory pattern due to SPrOO and less frequently at the ovulatory peaks due to SOptRO. The pathophysiologic processes of oocyte maturation in estrous animals and the circumstantial evidence of similar phenomena in humans are more appropriate to explain these coincidences than the temperature at conception hypothesis. © 2005 by Wiley Periodicals, Inc.
Parents' reports of the body shape and feeding habits of 36‐month‐old children: An investigation of gender differences
Authors: Holm‐Denoma Jill M. , Lewinsohn Peter M. , Gau Jeffrey M. , Joiner Thomas E. , Striegel‐Moore Ruth , Otamendi Ainhoa 
Published: October 2005

AbstractObjectiveThe current study examined parental perception of offspring body shape, differential reporting of offspring eating behaviors by mothers and fathers, and gender‐specific patterns of offspring feeding habits.MethodsParents of a community sample of 36‐month‐old children (N = 93) completed measures regarding their offspring's feeding patterns and body shape.ResultsResults revealed noteworthy correlates (e.g., concerns about their child's appetite) of parental perception of offspring weight status. They further suggested that mothers and fathers often differed in their accounts of their child's eating habits, and that parents report certain eating behaviors differently depending on the gender of their child.ConclusionClinical and theoretical implications are discussed. © 2005 by Wiley Periodicals, Inc.
Can we simultaneously work toward the prevention of obesity and eating disorders in children and adolescents?
Authors: Neumark‐Sztainer Dianne 
Published: October 2005

AbstractBecause of the growing prevalence of obesity among children and adolescents, increased attention is being directed toward its prevention. An important question is: Can we simultaneously work toward the prevention of obesity and eating disorders? To address this question, we need to determine (a) if there is a need for integrated approaches; (b) if we can bridge the fields of obesity and eating disorders; (c) if we can foster the development of environments that promote healthy eating and physical activity choices and the acceptance of diverse body shapes and sizes; and (d) if we can work toward the development of interventions that have relevance to a broad spectrum of weight‐related conditions and behaviors. © 2005 by Wiley Periodicals, Inc.
Microarray‐based CGH of sporadic and syndrome‐related pheochromocytomas using a 0.1–0.2 Mb bacterial artificial chromosome array spanning chromosome arm 1p
Authors: Aarts Marieke , Dannenberg Hilde , deLeeuw Ronald J. , van Nederveen Francien H. , Verhofstad Albert A. , Lenders J. W. , Dinjens Winand N. M. , Speel Ernst Jan M. , Lam Wan L. , de Krijger Ronald R. 
Published: October 2005

AbstractPheochromocytomas (PCC) are relatively rare neuroendocrine tumors, mainly of the adrenal medulla. They arise sporadically or occur secondary to inherited cancer syndromes, such as multiple endocrine neoplasia type II (MEN2), von Hippel‐Lindau disease (VHL), or neurofibromatosis type I (NF1). Loss of 1p is the most frequently encountered genetic alteration, especially in MEN2‐related and sporadic PCC. Previous studies have revealed three regions of common somatic loss on chromosome arm 1p, using chromosome‐based comparative genomic hybridization (CGH) and LOH analysis. To investigate these chromosomal aberrations with a higher resolution and sensitivity, we performed microarray‐based CGH with 13 sporadic and 11 syndrome‐related (10 MEN2A‐related and 1 NF1‐related) tumors. The array consisted of 642 overlapping bacterial artificial chromosome (BAC) clones mapped to 1p11.2‐p36.33. Chromosomal deletions on 1p were detected in 18 of 24 cases (75%). Among 9 tumors with partial 1p loss, the deleted region was restricted to 1cen‐1p32.3 in six cases (25%), indicating a region of genetic instability. The consensus regions of deletion in this study involved 1cen‐1p21.1, 1p21.3‐1p31.3, and 1p34.3‐1p36.33. In conclusion, these data strongly suggest that chromosome arm 1p is the site for multiple tumor suppressor genes, although the potential candidate genes CDKN2C and PTPRF/LAR are not included in these regions. © 2005 Wiley‐Liss, Inc.
Structure and growth of ultrasmall protein microcrystals by synchrotron radiation: II. µGISAX and microscopy of lysozyme
Authors: Pechkova Eugenia , Nicolini Claudio 
Published: October 2005

AbstractThe early steps of growth and nucleation of the lysozyme microcrystals by classical and nanotemplate‐based hanging vapor diffusion methods are studied using µGISAXS at the European Synchrotron Radiation Facility (ESRF) in Grenoble, France. Out‐of‐plane cuts in the Yoneda regions of the 2D scattering profiles point to the detection of ultrasmall lysozyme crystals by µGISAXS quite before than by light microscopy. Furthermore lysozyme crystal formation occurs quite earlier with the nanotemplate than with the classical method. Our data are compatible with two distinct modes of crystal nucleation and growth for P450sc and lysozyme. J. Cell. Biochem. © 2005 Wiley‐Liss, Inc.
Knocking down PML impairs p53 signaling transduction pathway and suppresses irradiation induced apoptosis in breast carcinoma cell MCF‐7
Authors: Bao‐Lei Tian , Zhu‐Zhong Mei , Yi Song , Jun‐Jie Qian , Yan Dong , Hua Liu , Bin Liu , Guo‐Wei Zhao , Zhi‐Xian Sun 
Published: October 2005

AbstractThe promyelocytic leukemia (PML) can selectively and dynamically recruit a number of proteins including p53 to form a sub‐nuclear multiprotein chamber named PML‐NBs. In DNA damage response, p53 is recruited into PML‐NBs and modified by phosphorylations and acetylations, which in turn potentiate its transcriptional and pro‐apoptotic activities. In contrast, in carcinoma cells, the role of PML in the irradiation induced p53‐mediated apoptosis is not precisely understood. In this study, we have used the breast carcinoma cell line, MCF‐7, and stably suppressed the expression of PML. Inhibition of PML expression had no detectable effect on the expression of endogenous p53 at the mRNA level; however, a significant decrease of p53 protein was observed. There was also an increase in the p53–MDM2 complexes, which may facilitate p53 protein degradation by the ubiquitin‐proteasome pathway, also in irradiation treated cells. The p53 transcriptional activity was attenuated both in unstressed and 10 Gy irradiation treated cells. Moreover, inhibition of PML expression in MCF‐7 cells significantly reduced p53 downstream genes, cell cycle arrest gene p21WAF/cip−1 and pro‐apoptotic gene Bax expression, then irradiation‐induced apoptosis. These results suggest that PML is a key regulator in the irradiation activated p53 apoptotic pathway in breast carcinoma cells. J. Cell. Biochem. © 2005 Wiley‐Liss, Inc.
MAP kinases p38 and JNK are activated by the steroid hormone 1α,25(OH)2‐vitamin D3 in the C2C12 muscle cell line
Authors: Buitrago Claudia G. , Ronda Ana C. , Boland Ana Russo de , Boland Ricardo 
Published: October 2005

AbstractIn chick skeletal muscle cell primary cultures, we previously demonstrated that 1α,25(OH)2‐vitamin D3 [1α,25(OH)2D3], the hormonally active form of vitamin D, increases the phosphorylation and activity of the extracellular signal‐regulated mitogen‐activated protein (MAP) kinase isoforms ERK1 and ERK2, their subsequent translocation to the nucleus and involvement in DNA synthesis stimulation. In this study, we show that other members of the MAP kinase superfamily are also activated by the hormone. Using the muscle cell line C2C12 we found that 1α,25(OH)2D3 within 1 min phosphorylates and increases the activity of p38 MAPK. The immediately upstream mitogen‐activated protein kinase kinases 3/6 (MKK3/MKK6) were also phosphorylated by the hormone suggesting their participation in p38 activation. 1α,25(OH)2D3 was able to dephosphorylate/activate the ubiquitous cytosolic tyrosine kinase c‐Src in C2C12 cells and studies with specific inhibitors imply that Src participates in hormone induced‐p38 activation. Of relevance, 1α,25(OH)2D3 induced in the C2C12 line the stimulation of mitogen‐activated protein kinase activating protein kinase 2 (MAPKAP‐kinase 2) and subsequent phosphorylation of heat shock protein 27 (HSP27) in a p38 kinase activation‐dependent manner. Treatment with the p38 inhibitor, SB203580, blocked p38 phosphorylation caused by the hormone and inhibited the phosphorylation of its downstrean substrates. 1α,25(OH)2D3 also promotes the phosphorylation of c‐jun N‐terminal protein kinases (JNK 1/2), the response is fast (0.5–1 min) and maximal phosphorylation of the enzyme is observed at physiological doses of 1α,25(OH)2D3 (1 nM). The relative contribution of ERK‐1/2, p38, and JNK‐1/2 and their interrelationships in hormonal regulation of muscle cell proliferation and differentiation remain to be established. J. Cell. Biochem. 97: 698–708, 2006. © 2005 Wiley‐Liss, Inc.
Tandem affinity purification revealed the hypusine‐dependent binding of eukaryotic initiation factor 5A to the translating 80S ribosomal complex
Authors: Jao David Li‐En , Chen Kuang Yu 
Published: October 2005

AbstractEukaryotic initiation factor 5A (eIF5A) is the only protein in nature that contains hypusine, an unusual amino acid formed post‐translationally in two steps by deoxyhypusine synthase and deoxyhypusine hydroxylase. Genes encoding eIF5A or deoxyhypusine synthase are essential for cell survival and proliferation. To determine the physiological function of eIF5A, we have employed the tandem affinity purification (TAP) method and mass spectrometry to search for and identify the potential eIF5A‐interacting proteins. The TAP‐tag was fused in‐frame to chromosomal TIF51A gene and eIF5A‐TAP fusion protein expressed at its natural level was used as the bait to fish out its interacting partners. At salt concentrations of 150 mM, deoxyhypusine synthase was the only protein bound to eIF5A. As salt concentrations were lowered to 125 mM or less, eIF5A interacted with a set of proteins, which were identified as the components of the 80S ribosome complex. The eIF5A–ribosome interaction was sensitive to RNase and EDTA treatments, indicating the requirement of RNA and the joining of 40S and 60S ribosomal subunits for the interaction. Importantly, a single mutation of hypusine to arginine completely abolished the eIF5A–ribosome interaction. Sucrose gradient sedimentation analysis of log versus stationary phase cells and eIF3 mutant strain showed that the endogenous eIF5A co‐sedimented with the actively translating 80S ribosomes and polyribosomes in an RNase‐ and EDTA‐sensitive manner. Our study demonstrates for the first time that eIF5A interacts in a hypusine‐dependent manner with a molecular complex rather than a single protein, suggesting that the essential function of eIF5A is mostly likely mediated through its interaction with the actively translating ribosomes. © 2005 Wiley‐Liss, Inc.
Cytoprotective effect of phloroglucinol on oxidative stress induced cell damage via catalase activation
Authors: Kang Kyoung Ah , Lee Kyoung Hwa , Chae Sungwook , Zhang Rui , Jung Myung Sun , Ham Young Min , Baik Jong Seok , Lee Nam Ho , Hyun Jin Won 
Published: October 2005

AbstractWe investigated the cytoprotective effect of phloroglucinol, which was isolated fromEcklonia cava(brown alga), against oxidative stress induced cell damage in Chinese hamster lung fibroblast (V79‐4) cells. Phloroglucinol was found to scavenge 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH) radical, hydrogen peroxide (H2O2), hydroxy radical, intracellular reactive oxygen species (ROS), and thus prevented lipid peroxidation. As a result, phloroglucinol reduced H2O2induced apoptotic cells formation in V79‐4 cells. In addition, phloroglucinol inhibited cell damage induced by serum starvation and radiation through scavenging ROS. Phloroglucinol increased the catalase activity and its protein expression. In addition, catalase inhibitor abolished the protective effect of phloroglucinol from H2O2induced cell damage. Furthermore, phloroglucinol increased phosphorylation of extracellular signal regulated kinase (ERK). Taken together, the results suggest that phloroglucinol protects V79‐4 cells against oxidative damage by enhancing the cellular catalase activity and modulating ERK signal pathway. © 2005 Wiley‐Liss, Inc.
Increased expression of δCaMKII isoforms in skeletal muscle regeneration: Implications in dystrophic muscle disease
Authors: Abraham S. Thomas , Shaw Carisa 
Published: October 2005

AbstractThe expression of δ isoforms of calcium‐calmodulin/dependent protein kinase II (CaMKII) has been reported in mammalian skeletal muscle; however, their functions in this tissue are largely unknown. This study was conducted to determine if δCaMKII expression was altered during regeneration of skeletal muscle fibers in two distinct models. In the first model, necrosis and regeneration were induced in quadriceps of normal mice by intramuscular administration of 50% glycerol. Immunostaining and confocal microscopy revealed that δCaMKII expression was clearly enhanced in fibers showing centralized nuclei. The second model was the mdx mouse, which undergoes enhanced muscle necrosis and regeneration due to a mutation in the dystrophin gene. sern blot analysis of hind leg extracts from 4 to 6 week old mdx mice revealed that δCaMKII content was decreased when compared to age‐matched control mice. This loss in δ kinase content was seen in myofibrillar and membrane fractions and was in contrast to unchanged δCaMKII levels in cardiac and brain extracts from dystrophic mice. Confocal microscopy of mdx quadriceps and tibialis muscle showed that δCaMKII expression was uniformly decreased in most fibers from dystrophic mice; however, enhanced kinase expression was observed in regenerating muscle fibers. These data support a fundamental role for δCaMKII in the regeneration process of muscle fibers in normal and mdx skeletal muscle and may have important implications in the reparative process following muscle death. © 2005 Wiley‐Liss, Inc.
Job stress, incivility, and counterproductive work behavior (CWB): the moderating role of negative affectivity
Authors: Penney Lisa M. , Spector Paul E. 
Published: October 2005

AbstractThe current study was designed to replicate findings from previous research regarding the relationships between job stressors, negative affectivity, and counterproductive work behavior (CWB) using peer‐reported data and to assess the effects of workplace incivility on employee satisfaction and CWB. Results indicate that incivility, organizational constraints, and interpersonal conflict were negatively related to job satisfaction and positively related to CWB. Support was also found for the role of negative affectivity as a moderator of the relationship between job stressors and CWB, although only one significant moderator was found using peer‐reported CWB. In general, the relationships between job stressors and CWB were stronger for individuals high in negative affectivity than for individuals low in negative affectivity. Copyright © 2005 John Wiley & Sons, Ltd.
Thau, S., Bennett, R. J., Stahlberg, D., & Werner, J. M. Why should I be generous when I have valued and accessible alternatives? Alternative exchange partners and OCB. Journal of Organizational Behavior Volume 25, 607–625
Authors: Thau Stefan 
Published: October 2005

AbstractThe original article to which this Erratum refers was published in Journal of Organizational Behavior 25(5) 2005, 607–625.
Alumina particles influence the interactions of cocultured osteoblasts and macrophages
Authors: Rodrigo A. , Vallés G. , Saldaña L. , Rodríguez M. , Martínez M. E. , Munuera L. , Vilaboa N. 
Published: October 2005

AbstractThe purpose of the current study was to evaluate the effects of alumina particles on secretion of several cytokines involved in bone resorption in cocultures of macrophages and osteoblasts. To distinguish the contribution of each individual cell type, we have established a heterologous in vitro system that makes use of mouse J774 cells and primary cultured human osteoblasts. J744 cells decreased the production of TNF‐α when they were cocultured with osteoblasts. Treatment of J744 cells with alumina particles increased TNF‐α secretion, but the induction was lower when cells were cocultured with osteoblasts. Secretion of IL‐6 by J744 cells was very low, and increased in the presence of osteoblasts. Alumina particles were only able to stimulate the release of IL‐6 by J744 cells when cells were cocultured with osteoblasts. On the other hand, incubation of osteoblasts with alumina particles enhanced the release of IL‐6 and GM‐CSF. Coculturing osteoblasts with J744 cells induced them to release IL‐6 and GM‐CSF, and treatment with alumina further increased the secretion of both mediators by osteoblasts. According to these in vitro results, it seems rather plausible that alumina particles are able to initiate an inflammatory response in vivo. © 2005 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res