bluuebunny/crossref_metadata_2025_split huggingface dataset:
Green hydrogen generation in alkaline solution using electrodeposited Ni-Co-nano-graphene thin film cathode
Authors: Shaarawy Hassan H. , Hussein Hala S. , Attia Adel , Hawash Salwa I. 
Published: April 2024

AbstractGreen hydrogen generation technologies are currently the most pressing worldwide issues, offering promising alternatives to existing fossil fuels that endanger the globe with growing global warming. The current research focuses on the creation of green hydrogen in alkaline electrolytes utilizing a Ni-Co-nano-graphene thin film cathode with a low overvoltage. The recommended conditions for creating the target cathode were studied by electrodepositing a thin Ni-Co-nano-graphene film in a glycinate bath over an iron surface coated with a thin copper interlayer. Using a scanning electron microscope (SEM) and energy-dispersive X-ray (EDX) mapping analysis, the obtained electrode is physically and chemically characterized. These tests confirm that Ni, Co, and nano-graphene are homogeneously dispersed, resulting in a lower electrolysis voltage in green hydrogen generation. Tafel plots obtained to analyze electrode stability revealed that the Ni-Co-nano-graphene cathode was directed to the noble direction, with the lowest corrosion rate. The Ni-Co-nano-graphene generated was used to generate green hydrogen in a 25% KOH solution. For the production of 1 kg of green hydrogen utilizing Ni-Co-nano-graphene electrode, the electrolysis efficiency was 95.6% with a power consumption of 52 kwt h−1, whereas it was 56.212. kwt h−1 for pure nickel thin film cathode and 54. kwt h−1 for nickel cobalt thin film cathode, respectively.
Influence of pH and temperature on the performance and microbial community during the production of medium-chain carboxylic acids using winery effluents as substrate
Authors: Villegas-Rodríguez Sharon B. , Arreola-Vargas Jorge , Buitrón Germán 
Published: April 2024

AbstractWinery effluents containing high ethanol concentrations and diverse organic matter are ideal substrates for producing medium-chain carboxylic acids via fermentation and chain elongation. However, the process needs to be better understood. This study presents novel insights into the bioconversion mechanisms of medium-chain carboxylic acids by correlating fermentation and chain elongation kinetic profiles with the study of microbial communities at different pH (5 to 7) conditions and temperatures (30 to 40 °C). It was found that high productivities of MCCA were obtained using a native culture and winery effluents as a natural substrate. Minor pH variations significantly affected the metabolic pathway of the microorganisms for MCCA production. The maximal productivities of hexanoic (715 mg/L/d) and octanoic (350 mg/L/d) acids were found at pH 6 and 35 °C. Results evidence that the presence of Clostridium, Bacteroides, and Negativicutes promotes the high productions of MCCA. The formation of heptanoic acid was favor when Mogibacterium and Burkholderia were present.
Graphical Abstract
Neurobehavioral dysfunction in a mouse model of Down syndrome: upregulation of cystathionine β-synthase, H2S overproduction, altered protein persulfidation, synaptic dysfunction, endoplasmic reticulum stress, and autophagy
Authors: Panagaki Theodora , Janickova Lucia , Petrovic Dunja , Zuhra Karim , Ditrói Tamás , Jurányi Eszter P. , Bremer Olivier , Ascenção Kelly , Philipp Thilo M. , Nagy Péter , Filipovic Milos R. , Szabo Csaba 
Published: April 2024

AbstractDown syndrome (DS) is a genetic condition where the person is born with an extra chromosome 21. DS is associated with accelerated aging; people with DS are prone to age-related neurological conditions including an early-onset Alzheimer’s disease. Using the Dp(17)3Yey/ + mice, which overexpresses a portion of mouse chromosome 17, which encodes for the transsulfuration enzyme cystathionine β-synthase (CBS), we investigated the functional role of the CBS/hydrogen sulfide (H2S) pathway in the pathogenesis of neurobehavioral dysfunction in DS. The data demonstrate that CBS is higher in the brain of the DS mice than in the brain of wild-type mice, with primary localization in astrocytes. DS mice exhibited impaired recognition memory and spatial learning, loss of synaptosomal function, endoplasmic reticulum stress, and autophagy. Treatment of mice with aminooxyacetate, a prototypical CBS inhibitor, improved neurobehavioral function, reduced the degree of reactive gliosis in the DS brain, increased the ability of the synaptosomes to generate ATP, and reduced endoplasmic reticulum stress. H2S levels in the brain of DS mice were higher than in wild-type mice, but, unexpectedly, protein persulfidation was decreased. Many of the above alterations were more pronounced in the female DS mice. There was a significant dysregulation of metabolism in the brain of DS mice, which affected amino acid, carbohydrate, lipid, endocannabinoid, and nucleotide metabolites; some of these alterations were reversed by treatment of the mice with the CBS inhibitor. Thus, the CBS/H2S pathway contributes to the pathogenesis of neurological dysfunction in DS in the current animal model.
Age and entrepreneurship: Mapping the scientific coverage and future research directions
Authors: Syed Raihan Taqui , Singh Dharmendra , Ahmad Nisar , Butt Irfan 
Published: April 2024

AbstractResearchers’ interest in studying the relationship between age and entrepreneurship has mushroomed in the last decade. While over a hundred articles are published and indexed in the Scopus database alone with varying and fragmented results, there has been a lack of effort in reviewing, integrating, and classifying the literature. This article offers a framework-based systematic review of 174 articles to comprehend the relationship and influencing factors related to an individual's age and entrepreneurship. Bibliographic coupling is used to identify the prominent clusters in the literature on this topic and the most influential articles. Also, the TCCM review framework is adopted to provide a comprehensive insight into dominant theories applied, contexts (geographic regions and industries) incorporated, characteristics (antecedents, consequences, mediating and moderating variables, and their relationships) investigated, and research methods employed in age and entrepreneurship research over the last fifteen (2007–2022). Though the literature covers an array of industries, to better understand the age-entrepreneurship correlation, we need to investigate the new-age technologically driven business sectors further to expand our knowledge. Furthermore, we detect that the Theory of Planned Behavior mostly dominates the literature, with other theories trivially employed. Finally, we apply the TCCM framework to suggest fertile areas for future research.
Neuroentrepreneurship: state of the art and future lines of work
Authors: Juárez-Varón David , Zuluaga Juan Camilo Serna , Recuerda Ana Mengual 
Published: April 2024

AbstractThis study aims to conduct a literature review and examine key research topics within the field of neuroentrepreneurship, categorizing works based on this classification and specifying different directions of research lines. Additionally, it seeks to compile definitions and their evolution regarding the concept of neuroentrepreneurship, contributing a new proposal. The methodology involves identifying keywords related to main themes and their direct relation to all research works encompassed in the entrepreneurship spectrum. Research articles matching the query are extracted from the Web of Science (WoS) and Scopus databases, as they provide a comprehensive citation search and access to multidisciplinary research, adhering to established inclusion-exclusion criteria. Findings allow the classification of contributions to the literature into four themes: Neuroscience and entrepreneurship, the use of neurotechnologies in entrepreneurship research, the neurological profile of the entrepreneur, and ethics in neuroentrepreneurship. Lastly, this study emphasizes its originality by presenting a set of works directly related to neuroentrepreneurship, establishing a classification based on four thematic research lines in neuroentrepreneurship. This allows extracting a limited set of definitions for the concept, classifying them based on themes incorporated in the definition. Finally, the authors provide a comprehensive definition of neuroentrepreneurship, tailored to the four major research blocks in this discipline.
Financial stress and quit intention: the mediating role of entrepreneurs’ affective commitment
Authors: Kleine Anne-Kathrin , Schmitt Antje , Wisse Barbara M. 
Published: April 2024

AbstractOne primary reason why entrepreneurs abandon their entrepreneurial goals is due to pressing financial difficulties. In one experimental and two field studies, we investigated the relationship between entrepreneurs’ financial stress and their intention to quit their businesses. In line with the challenge–hindrance stressor (CHS) framework, all three studies showed a positive link between financial stress and quit intention, both concurrently and over time. Furthermore, drawing on self-determination theory (SDT), we found support for affective commitment (but not continuance commitment) to the entrepreneurial endeavors as a mediator of the relationship. The findings provide novel insights into financial stress as a relevant entrepreneurial hindrance stressor and the role of the emotional bond formed (and dissolved) between entrepreneurs and their jobs as the mediating mechanism. Practical suggestions include considering the affective commitment levels of entrepreneurs to enhance consultancy and decision-making in entrepreneurship.
Development of an LC–MS/MS method for the determination of five psychoactive drugs in postmortem urine by optimization of enzymatic hydrolysis of glucuronide conjugates
Authors: Matsuo Tomohito , Ogawa Tadashi , Iwai Masae , Kubo Katsutoshi , Kondo Fumio , Seno Hiroshi 
Published: April 2024

Abstract
Purpose
Toxicological analyses of biological samples play important roles in forensic and clinical investigations. Ingested drugs are excreted in urine as conjugates with endogenous substances such as glucuronic acid; hydrolyzing these conjugates improves the determination of target drugs by liquid chromatography–tandem mass spectrometry (LC–MS/MS). In this study, we sought to improve the enzymatic hydrolysis of glucuronide conjugates of five psychoactive drugs (11-nor-9-carboxy-Δ9-tetrahydrocannabinol, oxazepam, lorazepam, temazepam, and amitriptyline).

Methods
The efficiency of enzymatic hydrolysis of glucuronide conjugates in urine was optimized by varying temperature, enzyme volume, and reaction time. The hydrolysis was performed directly on extraction columns. This analysis method using LC–MS/MS was applied to forensic autopsy samples after thorough validation.

Results
We found that the recombinant β-glucuronidase B-One® quantitatively hydrolyzed these conjugates within 3 min at room temperature directly on extraction columns. This on-column method saved time and eliminated the loss of valuable samples during transfer to the extraction column. LC–MS/MS-based calibration curves processed with this method showed good linearity, with r2 values exceeding 0.998. The intra- and inter-day accuracies and precisions of the method were 93.0–109.7% and 0.8–8.8%, respectively. The recovery efficiencies were in the range of 56.1–104.5%. Matrix effects were between 78.9 and 126.9%.

Conclusions
We have established an LC–MS/MS method for five psychoactive drugs in urine after enzymatic hydrolysis of glucuronide conjugates directly on extraction columns. The method was successfully applied to forensic autopsy samples. The established method will have broad applications, including forensic and clinical toxicological investigations.
Use of industrial wastes for stabilizing expansive clays in pavement applications: durability and microlevel investigation
Authors: Zimar Z. , Robert D. , Giustozzi F. , Zhou A. , Setunge S. , Kodikara J. 
Published: April 2024

AbstractExpansive clays feature high compressibility and large swelling-shrinkage potential, which may cause significant damage to the infrastructures, including pavements. This study investigates the potential use of industrial waste ash generated from municipal solid waste incineration (MSWI) as a more sustainable treatment method to treat expansive soils compared to the use of conventional coal fly ash. A series of tests was conducted to study the mechanical, durability, and environmental performance of the MSWI fly ash in comparison with the coal fly ash. The study reveals that the compressive strength and resilient modulus of 20% MSWI fly ash treated sample increased to 0.86 MPa and 213 MPa respectively, depicting an increase of 150% and 240% of the control clay specimen. Results also indicate that MSWI treated expansive clay shows better performance during the soaked California bearing ratio (CBR) testings, moisture susceptibility and cyclic wetting–drying tests compared to coal fly ash treated samples. Microlevel investigations reveal that the influence of cation exchange is more decisive in the MSWI-treated clays due to the presence of higher Ca2+ ions, during the early stages, and the influence of hydration is stronger at the later stage of stabilisation. X-ray diffraction (XRD) results show that gismondine, albite, calcite, portlandite, andradite, and ettringite are the main crystalline phases formed during the stabilization. Heavy metal concentrations after the stabilisation are within the allowable limit defined by state regulations. Applying MSWI fly ash as a ground treatment for expansive clays can reduce the consumption of natural resources, promoting a “zero landfill” policy.
Particle size distribution (PSD) estimation using unmanned aerial vehicle (UAV) photogrammetry for rockfill shear strength characterization
Authors: Arrieta Marco , Zhang Zong-Xian 
Published: April 2024

AbstractThe strength of rockfills and waste materials is significantly influenced by their particle size distribution (PSD). For large waste rockfills, PSD is fundamental to determine the shear behavior. Traditionally, PSD for rockfill, used in materials like coarse-grained aggregates, has been obtained through physical sieving. However, the particle sizes in hard rockfills can vary significantly from small particles (< 20 cm diameter) to large blocks or boulders over 100 cm, with the maximum size limited by the in situ ground conditions and blasting performance. Essentially, the sieving process is impractical, considering the scale of the mine waste dumps and the time required. Therefore, in this study, a workflow using digital detection to estimate the PSD is presented, aiming to quantify the waste dump shear strength using Barton–Kjaernsli empirical criterion. PSD from UAV is validated using manual field measurements of individual boulders. The error for coarse characteristic size prediction ranges within ± 4 mm, and the increase in the data collection frequency, area covered, and resolution of fragmentation measurement for rockfills and waste dumps using UAV allows to improve the statistical reliability of the PSD and fragmentation measurement.
Comparing patient-reported outcomes and lifestyle factors before and after the COVID-19 pandemic among Black and Hispanic breast cancer survivors in New Jersey
Authors: Sánchez-Díaz Carola T. , Zeinomar Nur , Iyer Hari S. , Perlstein Marley , Gonzalez Brian D. , Hong Chi-Chen , Bandera Elisa V. , Qin Bo 
Published: April 2024

Abstract
Purpose
The impact of the COVID-19 pandemic restrictions in the US since March 2020 on cancer survivorship among Black and Hispanic breast cancer (BC) survivors remains largely unknown. We aimed to evaluate associations of the pandemic with participant characteristics, patient-reported outcomes (PROs), and lifestyle factors among Black and Hispanic BC survivors in the Women’s Circle of Health Follow-Up Study and the New Jersey BC Survivors Study.

Methods
We included 447 Black (npre = 364 and npost = 83) and 182 Hispanic (npre = 102 and npost = 80) BC survivors who completed a home interview approximately 24 months post-diagnosis between 2017 and 2023. The onset of the pandemic was defined as March 2020. The association of the pandemic with binary outcomes was estimated using robust Poisson regression models.

Results
Hispanic and Black BC survivors recruited after the onset of the pandemic reported higher socioeconomic status and fewer comorbidities. Black women in the post-pandemic group reported a higher prevalence of clinically significant sleep disturbance (prevalence ratio (PR) 1.43, 95% CI 1.23, 1.68), lower sleep efficiency, and lower functional well-being, compared to the pre-pandemic group. Hispanic women were less likely to report low health-related quality of life (vs. high; PR 0.62, 95% CI 0.45, 0.85) after the onset of the pandemic.

Conclusions
Ongoing research is crucial to untangle the impact of the pandemic on racial and ethnic minorities participating in cancer survivorship research, as well as PROs and lifestyle factors.

Implications for Cancer Survivors
This study highlights the importance of considering the impact of the pandemic in all aspects of research, including the interpretation of findings.
Operationalization of coopetition performance: challenge accepted
Authors: Klimas Patrycja , Gadomska-Lila Katarzyna , Sachpazidu Karina 
Published: April 2024

AbstractIt is indisputable that coopetition exerts an influence on firm performance. However, a critical question persists: How should we comprehensively measure the performance of coopetition itself?. This paper addresses the inconsistencies in understanding coopetition performance by proposing a comprehensive and multi-dimensional approach to its operationalization. The methodology employed to develop an operationalization framework covered field and desk research implemented sequentially. The first stage used a meta-systematic literature review to identify how coopetition performance has been operationalized and measured in quantitative studies to date. The second stage used online focus group interviews to verify and develop the findings from the desk research. This stage aimed to gain a shared approach to the understanding and operationalization of coopetition performance based on discussion and confrontation of the literature with the (consistent, inconsistent, but also contradictory) opinions of experienced coopetition researchers. This study offers a noteworthy contribution by presenting a definition and five specific recommendations for the operationalization of coopetition performance, and highlighting approaches to be avoided. These findings enhance our comprehension of the coopetition performance construct, thereby advancing the knowledge in the field.
Application of Cold Plasma Technology on the Postharvest Preservation of In-Packaged Fresh Fruit and Vegetables: Recent Challenges and Development
Authors: Nikzadfar Mehrad , Kazemi Amirali , Abooei Reyhane , Abbaszadeh Rouzbeh , Firouz Mahmoud Soltani , Akbarnia Abbas , Rashvand Mahdi 
Published: April 2024

AbstractCold plasma, an emerging and versatile non-thermal technology, has gained substantial attention, particularly in the domain of surface modification, specifically within the context of packaging films. Recent developments in cold plasma technology have unveiled its potential to improve various aspects of packaged films, including chemical composition, physical attributes, structural characteristics, and overall functionality. These enhancements encompass surface roughness, contact angles, flexibility, thermal stability, barrier properties, and antimicrobial efficacy. The imperative for the advancement and expansion of decay-control technologies is crucial, not only for preserving the quality of fresh fruits and vegetables but also for mitigating biological risks throughout postharvest, processing, and storage. This, in turn, extends the shelf life of these products. This review aims to comprehensively outline the various systems utilized in in-package cold plasma (CP) treatments and their interactions with key parameters that significantly influence the efficacy of the process on fruits and vegetables. In this order, the review furnishes a comprehensive understanding of the mechanisms through which cold plasma impacts the quality characteristics of diverse fruits and vegetables. The review paper examines the potential of cold plasma technology in inhibiting spoilage and pathogenic microorganisms, deactivating enzymes, and altering the physical, mechanical, and chemical characteristics of fresh fruits and vegetables during packaging. Furthermore, It deals with the effect of cold plasma technology on increasing the quality and characteristics of edible films, alongside its utilization as an antimicrobial agent in food packaging.
Enhanced Biocompatibility by Evaluating the Cytotoxic and Genotoxic Effects of Magnetic Iron Oxide Nanoparticles and Chitosan on Hepatocellular Carcinoma Cells (HCC)
Authors: Fahmy Heba M. , Shekewy Samar , Elhusseiny Fathi A. , Elmekawy Ahmed 
Published: April 2024

AbstractHepatocellular carcinoma (HCC), the fifth most prevalent cancer worldwide, is influenced by a myriad of clinic-pathological factors, including viral infections and genetic abnormalities. This study delineates the synthesis, characterization, and the biological efficacy of iron oxide nanoparticles (Fe3O4) and chitosan-coated iron oxide nanoparticles (Fe3O4-CS) against HCC. Analytical methods confirmed the successful synthesis of both nanoparticles, with Fe3O4-CS demonstrating a smaller, uniform spherical morphology and distinct surface and magnetic properties attributable to its chitosan coating. The prepared materials were analyzed using various techniques, and their potential cytotoxic effects on HepG2 cancer cells line for HCC were investigated. In biological evaluations against HepG2 cells, a notable distinction in cytotoxicity was observed. Fe3O4 showed modest anticancer activity with an IC50 of 383.71 ± 23.9 µg/mL, whereas Fe3O4 exhibited a significantly enhanced cytotoxic effect, with a much lower IC50 of 39.15 ± 39.2 µg/mL. The Comet assay further evidenced Fe3O4-CS potent DNA damaging effect, showcasing its superior ability to induce apoptosis through extensive DNA fragmentation. Biochemical analyses integrated into our results reveal that Fe3O4-CS not only induces significant DNA damage but also markedly alters oxidative stress markers. Compared to control and Fe3O4-treated cells, Fe3O4-CS exposure significantly elevated levels of oxidative stress markers: superoxide dismutase (SOD) increased to 192.07 U/ml, catalase (CAT) decreased to 0.03 U/L, glutathione peroxidase (GPx) rose dramatically to 18.76 U/gT, and malondialdehyde (MDA) levels heightened to 30.33 nmol/gT. These results underscore the potential of Fe3O4-CS nanoparticles not only in inducing significant DNA damage conducive to cancer cell apoptosis but also in altering enzymatic activities and oxidative stress markers, suggesting a dual mechanism of action that may underpin their therapeutic advantage in cancer treatment. Our findings advocate for the further exploration of Fe3O4-CS nanoparticles in the development of anticancer drugs, emphasizing their capability to trigger oxidative stress and enhance antioxidant defense mechanisms.