bluuebunny/crossref_metadata_2025_split huggingface dataset:
How does national SOC monitoring on agricultural soils align with the EU strategies? An example using five case studies
Authors: Meurer Katharina H. E. , Hendriks Chantal M. J. , Faber Jack H. , Kuikman Peter J. , van Egmond Fenny , Garland Gina , Putku Elsa , Barancikova Gabriela , Makovníková Jarmila , Chenu Claire , Herrmann Anke M. , Bispo Antonio 
Published: March 2024

AbstractSoil functioning contributes to the delivery of a vast range of ecosystem goods and services, and ecosystem health is therefore reflected by the capacity of the soil to perform underlying functions. Soil organic carbon (SOC) is a key indicator for soil quality as it is an integral driver of many soil functions and associated ecosystem services. Across the globe, SOC stocks are declining due to expanding agriculture and unsustainable practices. Awareness of the fact that soil is a non‐renewable resource and its functioning important for all life on Earth is increasing, especially among policymakers. As such, goals for the preservation and restoration of SOC are formulated in policies under the European Green Deal. However, the evaluation of these goals at the European level is hampered by a non‐harmonized diversity in national SOC monitoring strategies. While some SOC indicators can be useful for the evaluation of most policy goals (i.e., baseline and potential SOC stocks), additional and contrasting SOC data are often required for the evaluation of the goals formulated by the different EU directives. This study provides an overview of five ongoing SOC monitoring programmes across Europe and discusses how national programmes may be aligned to evaluate goals at the EU level. Five countries with very different soil monitoring programmes were included in a case study to illustrate the potential for harmonization and standardization of SOC assessment. Based on this study, we conclude that SOC monitoring strategies can be harmonized, but not standardized. We further suggest five sampling strategies that have potential for harmonization under the proposed Directive on Soil Monitoring and Resilience.
Acetazolamide as an effective treatment for pilomotor seizures in autoimmune encephalitis
Authors: Gilani Kia , Tarazi Apameh , Wennberg Richard 
Published: March 2024

AbstractPilomotor seizures are strongly associated with autoimmune encephalitis (AE), particularly anti‐LGI1 encephalitis. The carbonic anhydrase inhibitor acetazolamide may have special efficacy for treating AE‐associated pilomotor seizures. Six patients with AE (five anti‐LGI1, one seronegative) and temporal lobe pilomotor seizures (five with seizures inducible by hyperventilation) were treated with acetazolamide, administered in a cycling (2‐days‐ON, 4‐days‐OFF) regimen to offset tolerance. Seizures were assessed during epilepsy monitoring unit (EMU) recordings in four inpatients (one of whom also maintained an outpatient seizure diary chronicling 1203 seizures over 1079 days); two outpatients self‐reported seizure frequencies. The extended diary revealed an inverse correlation between acetazolamide and proportion of seizures/day: 6%, 2% (days 1, 2 ON); 3%, 13%, 31%, 45% (days 1, 2, 3, 4 OFF). This patient later developed focal status epilepticus upon wean of antiseizure medications during a seropositive AE relapse that was remarkably aborted with acetazolamide monotherapy. The other three EMU patients averaged .56 seizures/day ON, and 3.81 seizures/day OFF (p = .004). The two outpatients reported seizure reductions from 3–5/day to 2/week, and 15–20/day to none, respectively, after initiation of cycling acetazolamide. Likely related to cerebral CO2/pH sensitivity, acetazolamide can be unusually effective in controlling pilomotor seizures in AE, chronically or in acute settings.
Clinical profile, treatment and quality of life of patients with psoriatic arthritis in Malaysia: A population‐based cross‐sectional study
Authors: Goh Shiau Fui , Wong Siu Bee , Robinson Suganthy , Tang Min Moon 
Published: March 2024

AbstractPsoriatic arthritis (PsA) is a major comorbidity of psoriasis and may lead to irreversible joint damage and disability. This study aims to describe the clinical profile, treatment and quality of life (QoL) of patients with PsA in Malaysia. This is a multicentre retrospective cross‐sectional study of psoriasis patients who were notified to the Malaysian Psoriasis Registry (MPR) from January 2007 to December 2018. Of 21 735 psoriasis patients, 2756 (12.7%) had PsA. The male to female ratio was 1:1. The mean age of psoriasis onset for PsA patients was 34.73 ± 14.44 years. They had a higher rate of family history of psoriasis (26% vs. 22.4%, p < 0.001), scalp (82.7% vs. 81.0%, p = 0.04) and nail involvement (73.3% vs. 53.3%, p < 0.001), obesity (62.6% vs. 54.4%, p < 0.001), dyslipidaemia (23.8% vs. 15.4%, p < 0.001), hypertension (31.1% vs. 22.7%, p < 0.001) and diabetes mellitus (20.9% vs. 15.2%, p < 0.001) compared to non‐PsA patients. More than half (54.3%) had severe psoriasis [(body surface area >10% and/or Dermatology Life Quality Index (DLQI) >10)]. Most had oligo‐/monoarthropathy (40.3%), followed by distal interphalangeal arthropathy (31.3%), symmetrical polyarthropathy (28.3%), spondylitis/sacroiliitis (8.2%) and arthritis mutilans (3.2%). Nearly 40% of PsA patients received systemic treatment, but only 1.6% received biologic agents. QoL was more significantly affected in PsA than in non‐PsA patients (mean DLQI 10.12 ± 7.16 vs. 9.52 ± 6.67, p < 0.001). One in eight patients with psoriasis in Malaysia had PsA. They had a higher incidence of comorbidities, severe disease, impaired QoL and were more likely to receive systemic and biological treatment compared to non PsA patients.
Analyses of tertiary lymphoid structures observed in cases of Merkel cell carcinoma showing spontaneous regression
Authors: Nakamura Motoki , Yoshimitsu Maki , Magara Tetsuya , Kano Shinji , Kato Hiroshi , Morita Akimichi 
Published: March 2024

AbstractMerkel cell carcinoma (MCC) is a high‐grade skin cancer, but spontaneous regression is observed at a markedly higher frequency than in other carcinomas. Although spontaneous regression is a phenomenon that greatly impacts treatment planning, we still cannot predict it. We previously reported on the prognostic impact of the presence or absence of tertiary lymphoid structures (TLS) and of Merkel cell polyomavirus (MCPyV) infection. To learn more about the spontaneous regression of MCC, detailed analyses were performed focusing on spontaneous regression cases. We collected 71 Japanese patients with MCC including 6 cases of spontaneous regression. Samples were analysed by immunostaining, spatial single‐cell analysis using PhenoCycler, and RNA sequencing using the next‐generation sequencer (NGS). All 6 cases of spontaneous regression were positive for MCPyV. TLS was positive in all 5 cases analysed. Spatial single‐cell analyses revealed that PD‐L1‐positive tumour cells were in close proximity to CD20‐positive B cell and CD3‐, 4‐positive T cells. Gene set enrichment analysis between MCPyV‐positive and TLS‐positive samples and other samples showed significantly high enrichment of “B‐cell–mediated immunity” gene sets in the MCPyV‐positive and TLS‐positive groups. In conclusion, TLS may play an important role in the spontaneous regression of MCC.
Cannabinoids for the treatment of autoimmune and inflammatory skin diseases: A systematic review
Authors: Kuzumi Ai , Yamashita Takashi , Fukasawa Takemichi , Yoshizaki‐Ogawa Asako , Sato Shinichi , Yoshizaki Ayumi 
Published: March 2024

AbstractIn recent years, the medical use of cannabinoids has attracted growing attention worldwide. In particular, anti‐inflammatory properties of cannabinoids led to their emergence as potential therapeutic options for autoimmune and inflammatory disorders. Recent studies have also shown that cannabinoid receptors are widely expressed and have endogenous ligands in the skin, suggesting that the skin has its own endocannabinoid system. The aim of this review is to discuss the potential therapeutic effects of cannabinoids in autoimmune and inflammatory skin diseases. Following an overview of cannabinoids and the endocannabinoid system, we describe the cellular and molecular mechanisms of cannabinoids in skin health and disease. We then review the clinical studies of cannabinoids in autoimmune and inflammatory skin diseases including systemic sclerosis (SSc), dermatomyositis (DM), psoriasis (Pso) and atopic dermatitis (AD). A primary literature search was conducted in July 2023, using PubMed and Web of Science. A total of 15 articles were included after excluding reviews, non‐human studies and in vitro studies from 389 non‐duplicated articles. Available evidence suggests that cannabinoids may be beneficial for SSc, DM, Pso and AD. However, further studies, ideally randomized controlled trials, are needed to further evaluate the use of cannabinoids in autoimmune and inflammatory skin diseases.
Coparenting as a family‐level construct: Parent and child inputs across the first two years
Authors: Bai Liu , Chimed‐Ochir Ulziimaa , Teti Douglas M. 
Published: March 2024

AbstractThis study examined the effects of infant negative affectivity (NA) and maternal and paternal depressive symptoms on fathers' and mothers' perceptions of coparenting across the first 2 years following an infant's birth. A total of 147 two‐parent families (most couples were White, married, and living together) with healthy, full‐term infants were recruited. At each time point, fathers and mothers separately reported their coparenting perceptions via the Coparenting Relationship Scale and their depressive symptoms using the depression subscale of Symptom Checklist‐90‐Revised. Mothers also reported their children's NA via the Infant Behavior Questionnaire‐Revised at 3 to 12 months and the Early Child Behavior Questionnaire at 18 and 24 months. Findings from growth curve models in an actor–partner interdependence model framework suggested that among parents with higher depression, there were steeper declines in coparenting quality reported by parents and their spouses across 3–24 months. In addition, three separate two‐way interactions between variables including higher‐than‐usual parental and spousal depression, as well as higher‐than‐usual infant NA predicted poorer‐than‐usual coparenting experiences. Findings indicate that coparenting is a dynamically unfolding construct that is impacted by ongoing changes in the parents' social‐ecological niche and suggest the need to consider both parent and child characteristics, and to include spousal influences, to get a comprehensive, whole‐family understanding of levels and changes in coparenting relationships. The findings also confirm that coparenting dynamics may benefit from interventions engaging both couples and addressing multiple risk factors from both parents (e.g., depression) and children (e.g., NA).
OnabotulinumtoxinA as a promising treatment for primary trochlear headache: A retrospective case series
Authors: Jaimes Alex , Gómez Andrea , Pajares Olga , Rodríguez‐Vico Jaime 
Published: March 2024

AbstractObjectivesTo report the efficacy of onabotulinumtoxinA (BoNTA) injections in relieving pain in patients with primary trochlear headache (PRTH).MethodsExamination of medical records for patients diagnosed with PRTH according to the International Classification of Headache Disorders, 3rd edition criteria and treated with BoNTA. Data were collected for variables related to pain relief, duration of effectiveness, and adverse effects.ResultsSix patients were included in the study. All had previously undergone standard care interventions, including infiltrations or oral treatments, yet experienced treatment failure or symptom recurrence. All patients received 20 units of BoNTA, administered in the corrugator and procerus muscles. Subsequent to the BoNTA injections, all six patients reported substantial pain relief, with five achieving complete remission of symptoms. The analgesic effect persisted for a duration of 3 months. No adverse events were reported in any of the cases.ConclusionsOur case series presents the first evidence of the potential of BoNTA as a safe and effective treatment option for PRTH. From a clinical standpoint, having a safer alternative is of paramount significance for patients with limited treatment options, such as those with PRTH. Further research is warranted to validate these findings and explore the long‐term efficacy of BoNTA in PRTH management.
Green synthesis of silver nanoparticles using Houttuynia cordata Thunb rhizome extracts and their antibacterial potential against common foodborne pathogens
Authors: Maimaiti Xiayidan , Bassey Anthony Pius , Liu Xiaoli , Zhu Yongsheng , Fan Linlin , Rahman Nurgul , Luo Runmeng , Wang Fan , Wang Ying 
Published: March 2024

SummaryThe biological synthesis of functionalised nanoparticles using plant materials is considered more cost‐effective and eco‐friendly than chemical and physical methods. Hence, this study demonstrated the synthesis of silver nanoparticles (AgNPs) using Houttuynia cordata Thunb rhizome (HCR). The extract, prepared with distilled water, provided the required phytochemical components, such as flavonoids, terpenoids, phenols, proteins and other essential bio‐reducing agents. The AgNPs were exposed to reaction conditions, such as temperatures, pH values and AgNO3 concentrations, to identify the optimum synthesis condition and explore their impacts on particle size and antibacterial action against Gram‐positive (Staphylococcus aureus) and Gram‐negative (Salmonella enterica and Shigella dysenteriae) foodborne pathogens. The formation of AgNPs was indicated by specific surface plasmon resonance (SPR) intensity at 440–450 nm and colour changes under different reaction conditions. The structure and size distribution characterised by SEM and TEM revealed that the AgNPs exhibited a spherical‐shaped structure with irregular contours, regular distribution and aggregation. Although the average particle size ranged from 2 to 100 nm, relatively smaller sizes were detected at 10 mM (54.30), 80 °C (49.50 nm) and pH 6 (60.16 nm) conditions. The FTIR spectrum and EDX spectral signals affirmed the presence of reducing and stabilising agents in HCR extract, following the reduction of AgNPs from Ag+ to Ag0. AgNPs also exhibited excellent antibacterial activity against S. aureus, S. enterica and Sh. dysenteriae, indicating a broad spectrum for various applications in the food and pharmaceutical industries.
Sustainable energy consumption behaviour with smart meters: The role of relative performance and evaluative standards
Authors: Wendt Charlotte , Kosin Dominick , Adam Martin , Benlian Alexander 
Published: March 2024

AbstractThe growing adoption of smart meters enables the measurement of households' energy consumption, influenced not solely by building characteristics such as thermal insulation but also by residents' behavioural patterns, such as heating and ventilation practices. To motivate residents to adopt more sustainable behaviours, user interfaces on smartphones and laptops are increasingly using consumption data from households' smart meters to enable effective goal‐setting. In contrast to previous research largely focusing on goal‐setting in isolation, this study examines the role of specific social comparison‐related design features that future research and practitioners can consider along with goal‐setting to stimulate sustainable behaviours. Specifically, we look into the influence of residents' perception of their relative performance (i.e., whether their behaviour was better or worse than a reference group) on their ambition to act (i.e., targeted improvement goal) and their actual energy consumption behaviour. Moreover, we investigate the influence of a goal's evaluative standard (i.e., whether the goal refers to one's own or other's performance) on the relationship between relative performance, ambition to act, and energy consumption behaviour. Drawing on social comparison theory, we conducted a framed field experiment with 152 households. We find that a goal's evaluative standard influences residents' awareness of their relative performance, affecting their ambition to act and, ultimately, their energy consumption behaviour. More specifically, we find that whereas other‐ (vs. self‐) referencing goals encourage residents from worse‐than‐average performing households more strongly to improve their energy consumption behaviour, they discourage better‐than‐average ones. Overall, our study provides novel insights into the interplay between relative performance and evaluative standards as a means of fostering social comparison in smart meter‐facilitated goal‐setting, highlighting their crucial role in effectively supporting sustainable behaviours.
Effect of platelet‐rich plasma on healing of lower extremity diabetic skin ulcers: A meta‐analysis
Authors: Fang Xiansong , Wang Xiaoling , Hou Ya , Zhou Liang , Jiang Yingjie , Wen Xiaoyun 
Published: March 2024

AbstractThe aim of this research is to explore the therapeutic efficacy of platelet‐rich plasma (PRP) on the cutaneous ulceration of diabetes mellitus (DM). From the beginning of the database until January 2024, we looked through several databases to obtain randomised, controlled PRP studies to treat the wound healing of DM in adult patients. The Cochrane Collaboration's Risk‐Of‐Bias Instrument was used to evaluate the risk of bias in randomised, controlled studies. Funnel plots, sensitivity analyses and Egger regression tests were employed to determine the reliability and effectiveness of the meta‐analyses. Depending on the degree of heterogeneity, a fixed or random effect model has been used. The statistical significance was determined to be below 0.05. Altogether 281 trials were collected from the database and entered into Endnote Software for screening, and 15 trials were analysed. It was found that PRP was associated with a higher rate of wound healing (OR, 3.23; 95% CI, 2.42, 4.31 p < 0.0001). PRP was associated with a reduction in the risk of post‐operative wound infection (OR, 0.46; 95% CI, 0.21, 0.99 p = 0.05). PRP was associated with a reduction in the risk of amputations amongst those with DM (OR, 0.50; 95% CI, 0.30, 0.84 p = 0.009). Overall, PRP treatment for DM is expected to improve the rate of wound healing, decrease the risk of wound infection and decrease the risk of amputations.
The beguiling behaviour of narcissistic CEOs: Evidence from repurchase announcements
Authors: Boamah Evans O. , Banerjee Shantanu 
Published: March 2024

AbstractWe study whether Chief Executive Officer (CEO) narcissism affects a firm's share repurchase announcements and their implementations. Using signature characteristics as a measure of narcissism, we find that US firms with narcissist CEOs are more likely to make repurchase announcements and announce higher repurchase dollar amounts. However, these firms are less likely to follow through. Actual repurchases by these firms are less frequent, and they use a smaller amount of cash for share buyback because they have a higher cashflow sensitivity of cash. Narcissist CEOs’ repurchase announcements are less driven by market timing and have a lower announcement effect compared to those by other CEOs. The higher rate and amount of repurchase announcements are more pronounced in poorly governed firms with narcissistic CEOs. These results are robust to various specifications including a difference‐in‐difference set‐up using CEOs’ exogenous turnover, controlling for other CEO traits and using an alternative measure of narcissism based on pronoun usage in CEO communications. Collectively, the results presented in this study demonstrate that narcissist CEOs play a critical role in the intensity of share repurchase announcements and their executions, particularly for firms with weaker governance structures.
Does corporate governance matter in competitive industries? Evidence from brokerage mergers and closures
Authors: Guo Savannah (Yuanyuan) , Saha Pritam , You Leyuan , Zheng Michael 
Published: March 2024

AbstractWe document that firms in competitive industries experience significantly more deterioration in financial reporting quality after a reduction in analyst coverage due to brokerage closures or mergers, as compared to firms in noncompetitive industries. Most of the effects are mainly driven by firms with smaller initial analyst coverage, lower institutional ownership and greater financial constraints. Importantly, we further show that after brokerage exits, managerial slack increases more for firms in noncompetitive than competitive industries. Consistent with the notion that agency manifestation can take different forms, we provide evidence that competition may curtail some agency issues, such as managerial slack, while also exacerbating other agency issues, such as financial misreporting.
First in man right atrial appendage implantation of a Micra leadless pacemaker
Authors: Pinon Pauline , Iserin Laurence , Hachem Fatma , Waldmann Victor 
Published: March 2024

AbstractIntroductionPacemaker implantation can be challenging in patients with congenital heart disease.Methods and ResultsIn a patient with Ebstein disease and symptomatic sinus node dysfunction, despite multiple attempts, the Micra® pacemaker could not be implanted in the severely dilated right ventricle. In that context, and after iodine injection to confirm the appropriate location, the Micra® pacemaker was successfully implanted in the right appendage at the first attempt.ConclusionDespite the recent development of dedicated dual‐chamber leadless pacemaker, to the best of our knowledge, this case is the first off‐label Micra® implantation in a right appendage.
The impact of handgrip strength and waist circumference on glycemic control: Prospective, observational study using outpatient clinical data in Japanese patients with type 2 diabetes mellitus
Authors: Nakanishi Shuhei , Shimoda Masashi , Kimura Tomohiko , Sanada Junpei , Fushimi Yoshiro , Iwamoto Yuichiro , Iwamoto Hideyuki , Dan Kazunori , Mune Tomoatsu , Kaku Kohei , Kaneto Hideaki 
Published: March 2024

ABSTRACTIntroductionLoss of muscle mass and the accumulation of visceral fat are known risk factors for the deterioration of glycemic control in type 2 diabetes mellitus. This study looked at the effects of such factors on glycemic control in Japanese patients with type 2 diabetes mellitus in the form of handgrip strength (HGS) and waist circumference (WC).Materials and MethodsIn this prospective, observational study, 233 patients with type 2 diabetes mellitus and a HbA1c level of ≥7.0% were followed for around 1 year, during which time they were studied for an understanding of the association between handgrip strength, waist circumference, and glycemic control (HbA1c <7.0%). Hazard ratios (HRs) and 95% confidence intervals (CIs) for glycemic control improvement by Cox hazards models were analyzed for handgrip strength and waist circumference.ResultsCompared with the low tertile, patients in the middle and high tertiles of handgrip strength when adjustment was carried out for waist circumference were 2.117 (1.142–3.924) and 4.670 (2.526–8.632), respectively. The HRs of patients in the middle and high tertiles of WC when adjustment was made for HGS were 0.442 (0.269–0.725) and 0.339 (0.191–0.604), respectively. Within the low, middle, and high HGS tertiles, the HRs for WC were 0.863 (0.797–0.934), 0.940 (0.899–0.982), and 1.009 (0.984–1.035), respectively, although the HRs for HGS within each WC tertile remained significant.ConclusionsHandgrip strength and waist circumference demonstrated independent associations for glycemic control, but the effect of waist circumference appeared to be at least partially canceled out by increased handgrip strength. The data suggest that handgrip strength might help to mitigate the negative impact of waist circumference on glycemic control.