bluuebunny/crossref_metadata_2025_split huggingface dataset:
Establishment and characterization of conditions required for tumor colonization by intravenously delivered bacteria
Authors: Yu Yong A. , Zhang Qian , Szalay Aladar A. 
Published: January 2008

AbstractIntravenously injected bacteria have the ability to enter and replicate within tumors in mice. Here, we further characterized this dynamic process by investigating the conditions required for tumor colonization by bacteria. We discovered that a broad range of bacteria, including both Gram‐negative and Gram‐positive strains, colonize a panel of syngeneic and xenogeneic tumors, as well as spontaneous tumors in mice. The colonization process is dependent on the stage of tumor development, but independent of tumor type. The entry and replication of bacteria in tumors was consistently achieved in nude mice when approximately 1 × 105 bacteria were injected. The majority of the bacteria were found in the central portion of the tumors, coinciding with the necrotic regions of sectioned tumors. We also found that, although cancer can be characterized as a chronic inflammation, inflammation alone, as seen in cutaneous wounds and in sites artificially induced by Sephadex, was not sufficient to sustain bacterial colonization. Furthermore, we found that “sensitizing” the tumors by oncolytic vaccinia virus colonization prior to bacterial delivery may help to enhance tumor colonization at least twofold by bacteria that were delivered subsequently. Taken together, the data from this and previous studies, lead us to propose the concept that blood‐borne bacteria enter tumors to amplify in the central necrotic region; and that, due to impaired immunosurveillance in the tumors as known previously, the clearance of bacteria is inhibited. Bacterial colonization of tumors could be achieved without any specific gene modifications either in bacteria or in the host. Biotechnol. Bioeng. 2008;100: 567–578. © 2008 Wiley Periodicals, Inc.
Carbohydrate‐Mediated Targeting of Antigen to Dendritic Cells Leads to Enhanced Presentation of Antigen to T Cells
Authors: Adams Eddie W. , Ratner Daniel M. , Seeberger Peter H. , Hacohen Nir 
Published: January 2008

AbstractThe unique therapeutic value of dendritic cells (DCs) for the treatment of allergy, autoimmunity and transplant rejection is predicated upon our ability to selectively deliver antigens, drugs or nucleic acids to DCs in vivo. Here we describe a method for delivering whole protein antigens to DCs based on carbohydrate‐mediated targeting of DC‐expressed lectins. A series of synthetic carbohydrates was chemically‐coupled to a model antigen, ovalbumin (OVA), and each conjugate was evaluated for its ability to increase the efficiency of antigen presentation by murine DCs to OVA‐specific T cells (CD4+ and CD8+). In vitro data are presented that demonstrate that carbohydrate modification of OVA leads to a 50‐fold enhancement of presentation of antigenic peptide to CD4+ T cells. A tenfold enhancement is observed for CD8+ T cells; this indicates that the targeted lectin(s) can mediate cross‐presentation of antigens on MHC class I. Our data indicate that the observed enhancements in antigen presentation are unique to OVA that is conjugated to complex oligosaccharides, such as a high‐mannose nonasaccharide, but not to monosaccharides. Taken together, our data suggest that a DC targeting strategy that is based upon carbohydrate‐lectin interactions is a promising approach for enhancing antigen presentation via class I and class II molecules.
A Library of Chiral Imidazoline–Aminophenol Ligands: Discovery of an Efficient Reaction Sphere
Authors: Arai Takayoshi , Yokoyama Naota , Yanagisawa Akira 
Published: January 2008

AbstractA library of imidazoline–aminophenol ligands was synthesized on solid supports. After immobilization of chiral chloromethylimidazolines 1 and 2 onto the polystyrylsulfonyl chloride, nucleophilic substitution with (R)‐ or (S)‐phenylethylamine (3 and 4) provided four combinations of polymer‐supported imidazoline–amine ligands. Further reductive alkylation using salicylaldehydes 7–10 provided a series of imidazoline–aminophenol ligands (L9–L24). Analysis by solid‐phase catalysis/circular dichroism high‐throughput screening of a copper‐catalyzed Henry reaction revealed that ligand L25, comprising a (S,S)‐diphenylethylenediamine‐derived imidazoline, (S)‐phenylethylamine, and dibromophenol, was highly efficient, thus providing the adduct of nitromethane and benzaldehyde in 95 % ee. The combination of stereogenic centers was crucial in promoting the highly stereoselective reactions. The unique reaction sphere of L25 was also examined in a Friedel–Crafts alkylation of indole and nitroalkene to give the adduct in up to 83 % ee.
A Two‐State Reactivity Rationale for Counterintuitive Axial Ligand Effects on the CH Activation Reactivity of Nonheme FeIVO Oxidants
Authors: Hirao Hajime , Que Lawrence , Nam Wonwoo , Shaik Sason 
Published: January 2008

AbstractThis paper addresses the observation of counterintuitive reactivity patterns of iron–oxo reagents, TMC(L)FeO2+,1+; L=CH3CN, CF3CO2−, N3−, and SR−, in O‐transfer to phosphines versus H‐abstraction from, for example, 1,4‐cyclohexadiene. Experiments show that O‐transfer reactivity correlates with the electrophilicity of the oxidant, but H‐abstraction reactivity follows an opposite trend. DFT/B3 LYP calculations reveal that two‐state reactivity (TSR) serves as a compelling rationale for these trends, whereby all reactions involve two adjacent spin‐states of the iron(IV)–oxo species, triplet and quintet. The ground state triplet surface has high barriers, whereas the excited state quintet surface features lower ones. The barriers, on any single surface, are found to increase as the electrophilicity of TMC(L)FeO2+,1+ decreases. Thus, the counterintuitive behavior of the H‐abstraction reactions cannot be explained by considering the reactivity of only a single spin state but can be rationalized by a TSR model in which the reactions proceed on the two surfaces. Two TSR models are outlined: one is traditional involving a variable transmission coefficient for crossover from triplet to quintet, followed by quintet‐state reactions; the other considers the net barrier as a blend of the triplet and quintet barriers. The blending coefficient (x), which estimates the triplet participation, increases as the quintet–triplet energy gap of the TMC(L)FeO2+,1+ reagent increases, in the following order of L: CH3CN > CF3CO2− > N3− > SR−. The calculated barriers predict the dichotomic experimental trends and the counterintuitive behavior of the H‐abstraction series. The TSR approaches make a variety of testable predictions.
ChemInform Abstract: Magnetic and Electronic Properties of CaCu3Cr4O12 and CaCu3Cr2Sb2O12 by First‐Principles Density Functional Calculation.
Authors: Xiang H. P. , Liu X. J. , Zhao E. J. , Meng J. , Wu Z. J. 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Oxygen‐17 Hyperfine Structures in the Pure Rotational Spectra of SrO, SnO, BaO, HfO and ThO.
Authors: Dewberry Christopher T. , Etchison Kerry C. , Grubbs Garry S. II , Powoski Robert A. , Serafin Michal M. , Peebles Sean A. , Cooke Stephen A. 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Two Ce(SO4)2×4H2O Polymorphs: Crystal Structure and Thermal Behavior.
Authors: Casari Barbara M. , Langer Vratislav 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: New Cobaltite Materials Containing CdI2‐Type Layers: Synthesis and Structures of Ba2Co4ClO7 and Ba2Co4BrO7.
Authors: Kauffmann Matthieu , Tancret Nathalie , Abraham Francis , Roussel Pascal 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Composition‐Induced Phase Transition in Ca14Zn6‐xGa10+xO35+x/2 (x = 0.0 and 0.5).
Authors: Istomin S. Ya. , Chernov S. V. , Antipov E. V. , Dobrovolsky Yu. A. 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Phase Transition Between Two Anhydrous Modifications of NaHSO4 Mediated by Heat and Water.
Authors: Zangmeister Christopher D. , Pemberton Jeanne E. 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis, Crystal Structure, Cationic Mobility, Thermal Evolution and Spectroscopic Study of Cs8(UO2)4(WO4)4 (WO5)2 Containing Infinite Uranyl Tungstate Chains.
Authors: Yagoubi Said , Obbade Said , Benseghir Mohamed , Abraham Francis , Saadi Mohamed 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis, Structure and Magnetic Properties of New Vanadate PbCo2V2O8.
Authors: He Zhangzhen , Ueda Yutaka , Itoh Mitsuru 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Iodine‐Mediated Cyclization of Thiobenzamides to Produce Benzothiazoles and Benzoxazoles.
Authors: Downer‐Riley Nadale K. , Jackson Yvette A. 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Light‐Sensitive Protecting Groups for Amines and Alcohols: The Photosolvolysis of N‐Substituted 7‐Nitroindolines.
Authors: Hassner Alfred , Yagudayev Diana , Pradhan Tarun K. , Nudelman Abraham , Amit Boaz 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: ZrOCl2 Catalyzed Chemoselective Conversion of Aldehydes to geminal‐Diacetates and Their Cleavage: A Mild and Efficient Method.
Authors: Nagaraj Adki , Reddy Cherkupally Sanjeeva 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Smaller Building Blocks Form Larger Assemblies: Aggregation Behavior of Biaryl‐Based Dendritic Facial Amphiphiles.
Authors: Ambade Ashootosh V. , Aathimanikandan Sivakumar V. , van der Poll Derek , Thayumanavan S. 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Enantioselective Benzoylation of α‐Amino Esters Using (S)‐1‐Benzoyl‐2‐(α‐acetoxyethyl)benzimidazole, a Chiral Benzimidazolide.
Authors: Karnik Anil V. , Kamath Suchitra S. 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Prolinol tert‐Butyldiphenylsilyl Ether as Organocatalyst for the Asymmetric Michael Addition of Cyclohexanone to Nitroolefins.
Authors: Liu Fengying , Wang Shiwen , Wang Ning , Peng Yungui 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Ligand‐Bridged and Bis‐Ligand‐Coordinated Titanium Complexes: Synthesis, Structure and Relevance to Phenylacetylene Hydroanilination Catalysis.
Authors: Han Xiao‐Yu , Li Ya‐Hong , Wei Hua , Zhang Yong 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Trimethylsilyl Trifluoromethanesulfonate as a Metal‐Free, Homogeneous and Strong Lewis Acid Catalyst for Efficient One‐Pot Synthesis of α‐Aminonitriles and Their Fluorinated Analogues
Authors: Prakash G. K. Surya , Panja Chiradeep , Do Clement , Mathew Thomas , Olah George A. 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: N‐Heterocyclic Carbene Catalyzed Aza‐Morita—Baylis—Hillman Reaction of Cyclic Enones with N‐Tosylarylimines.
Authors: He Lin , Jian Teng‐Yue , Ye Song 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Facile Stereoselective Synthesis of (E)‐ and (Z)‐α‐Substituted Cinnamates: Stereospecific Dehydration Reaction with 1‐Ethyl‐3‐(3‐dimethylaminopropyl)carbodiimide (EDC) and Copper(II) Chloride.
Authors: Sai Hiroshi , Ogiku Tsuyoshi , Ohmizu Hiroshi 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Iodinane‐ and Metal‐Free Synthesis of N‐Cyano Sulfilimines: Novel and Easy Access of NH‐Sulfoximines.
Authors: Garcia Mancheno Olga , Bistri Olivia , Bolm Carsten 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Heterogeneous Pd/C‐Catalyzed Ligand‐Free Suzuki—Miyaura Coupling Reaction Using Aryl Boronic Esters.
Authors: Kitamura Yoshiaki , Sakurai Ai , Udzo Takahiro , Maegawa Tomohiro , Monguchi Yasunari , Sajiki Hironao 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Valsartan via Decarboxylative Biaryl Coupling.
Authors: Goossen Lukas J. , Melzer Bettina 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Ligand‐Free Stille Cross‐Coupling Reaction Using Pd/CaCO3 as Catalyst Reservoir.
Authors: Coelho Aline V. , de Souza Andrea Luzia F. , de Lima Paulo G. , Wardell James L. , Antunes O. A. C. 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: An Efficient and Practical Process for Pd/Cu Cocatalyzed Homocoupling Reaction of Terminal Alkynes Using Sodium Percarbonate as a Dual Reagent in Aqueous Media.
Authors: Zhou Lei , Zhan Hai‐Ying , Liu Hai‐Ling , Jiang Huan‐Feng 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: 1‐Chloro‐4,5,6,7‐tetraalkyldihydroindene Formation by Reaction of Bis(cyclopentadienyl)titanacyclopentadienes with Titanium Chloride.
Authors: Takahashi Tamotsu , Song Zhiyi , Sato Kimihiko , Kuzuba Yuichi , Nakajima Kiyohiko , Kanno Ken‐ichiro 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of 1‐Arylmethyl‐2‐(2‐cyanoethyl)aziridines and Their Rearrangement into Novel 2‐(Aminomethyl)cyclopropanecarbonitriles.
Authors: D'hooghe Matthias , Vervisch Karel , De Kimpe Norbert 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Novel Cyclization Reaction Between 2,3‐Bis(trimethylsilyl)buta‐1,3‐diene and Acyl Chlorides with Straightforward Formation of Polysubstituted Furans.
Authors: Babudri Francesco , Cicco Stefania R. , Farinola Gianluca M. , Lopez Linda C. , Naso Francesco , Pinto Vita 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Nef Reaction of Nitropyrrolidines: Novel Synthesis of Hydroxypyrrolidine Derivatives.
Authors: Pak Chwang Siek , Nyerges Miklos 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Tandem Reductive Cyclization of Diethyl 2‐(2‐Nitro‐1‐arylethyl)malonate by Zinc and Ammonium Chloride in Aqueous Medium.
Authors: Jayapradha S. R. , Muthusubramanian S. 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Comparison of Benzene, Nitrobenzene, and Dinitrobenzene 2‐Arylsulfenylpyrroles.
Authors: Garabatos‐Perera Jose R. , Rotstein Benjamin H. , Thompson Alison 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: An Efficient Process for the Bromolactamization of Unsaturated Acids.
Authors: Yeung Ying‐Yeung , Corey E. J. 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Chemistry of Pyrrolo[1,2‐a]indole‐ and Pyrido[1,2‐a]indole‐Based Quinone Methides. Mechanistic Explanations of Differences in Cytostatic/Cytotoxic Properties.
Authors: Khdour Omar , Skibo Edward B. 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.