bluuebunny/crossref_metadata_2025_split huggingface dataset:
AN EXAMINATION OF THE RELATIONSHIP BETWEEN THE CONCEPTS OF PROJECTIVE IDENTIFICATION AND INTERSUBJECTIVITY
Authors: Weaver Carol 
Published: November 2006

ABSTRACT
Projective identification has been described as‘the most fruitful psychoanalytic concept since the discovery of the unconscious’ (Young 1994, p. 120). Many psychoanalysts, including Ogden, have also begun exploring the philosophical concept of intersubjectivity and how it may augment psychoanalytic understanding and practice. Existential psychotherapists include those who believe that intersubjectivity is the basic way in which humans relate. Diamond writes that‘Without a notion of intersubjectivity, psychoanalysis is in difficulty, for it is impossible to envisage how feelings belonging to one individual pass into another’ (Diamond 1998, p. 202).After exploring the concept of projective identification and the claims from various contemporary psychoanalysts that this mechanism is interpersonal rather than purely intrapsychic, the paper explores the philosophical concept of intersubjectivity. The communication of emotion and the implications for therapy are then discussed, before conclusions are drawn about the relationship between the two concepts under examination.
ESTABLISHING PSYCHODYNAMIC PSYCHOTHERAPY WITHIN THE NHS: THE SOUTHERN COUNTIES MODEL
Authors: Maloney Chris , Haigh Rex , Knowles Jane , Rees Jean 
Published: November 2006

ABSTRACT
Development of psychodynamic psychotherapy services has not been a priority in recent years, and existing services have a responsibility to provide impetus for growth and development of provision across the . Southern Counties Psychotherapy is a federation of psychodynamic psychotherapy services providing a Clinical Training in Psychodynamic Psychotherapy within the NHS, linked to an M.Sc. in Psychodynamic Psychotherapy in Health Service Settings. This is a rigorous analytic training, to the standards of the UKCP PPP Section, specifically addressing realities of practice within the NHS and the relationship to broader mental health services. The core philosophy is that good quality psychodynamic psychotherapies can only be available for populations if good quality psychodynamic psychotherapy training is also readily available.We offer this description of the course and its background as encouragement for others who may want to set up similar projects, and to invite collaborators.
THE STATUTORY REGULATORY BODY PERSPECTIVE
Authors: Burley Peter 
Published: November 2006

ABSTRACT
This paper surveys the legislative context for the statutory regulation of psychotherapy as in summer 1999. It looks at the public policy of regulation. The Parliamentary progress of the Health Bill (Health Act, as of 30 June 1999) is examined and its successful outcome for professions. The experience of State Registration for a profession is explored and benefits elaborated. The options for how the profession might take up the new opportunities are presented and a timescale indicated.This is an overview of the topic and cannot attempt to do it justice in detail. Areas such as the history of regulated professions, how educational approvals are conducted, devolution, complaints and conduct procedures and many others will have to be dealt with elsewhere.
GROUP‐ANALYTIC PSYCHOTHERAPY WITH THE ELDERLY
Authors: Canete Maria , Stormont Fiona , Ezquerro Arturo 
Published: November 2006

ABSTRACT
Orthodox psychoanalysis offered the view that mental processes in the elderly are too rigidly established for favourable treatment results. Group psychotherapy with the elderly in general has received little attention, mostly concentrating on inpatient groups. The main focus has been on supportive techniques, often in institutional settings.Two of the authors (Maria Canete and Fiona Stormont) co‐conducted a weekly slow‐open analytic group for elderly people, in a London outpatient NHS clinic. This paper presents clinical material that illustrates some age‐specific issues, as they appear in the group process. For example, issues of competitiveness, rivalry and aggression, which are generally present in the beginning of groups with younger people, tend to be absent, or manifest themselves differently, in the elderly group. Denial of age becomes impossible, which helps these patients to accept approaching death and the process of dying itself. Psychoanalytic group psychotherapy can be especially indicated for this age population.
THERAPY AS MEMORY‐WORK: DILEMMAS OF DISCOVERY, RECOVERY AND CONSTRUCTION
Authors: Burman Erica 
Published: November 2006

ABSTRACT
In this paper I have sought to shift the focus on the construction of memory within psychotherapeutic practice in a number of different directions to draw some more general lessons for the process and status of therapeutic accounts. The precipitating context for the current scrutiny of memory‐making within therapy may have limited its scope and fruitfulness. The fact that this issue was largely prompted by debates about the status of (usually) adult women's recovery of memories of early abuse within therapy is a relevant factor that has been compounded by issues of professional credibility and hierarchy. Clearly, at a cultural level, women's memories of childhood abuse function politically as well as personally, as reflected by the social and legal responses to this challenge.However, guidelines for professional practice cannot legislate for the indeterminacies surrounding the subjectivity of memory, while assumptions underlying the empirical psychological resources drawn upon to inform debates in psychotherapy require critical scrutiny. Clinical and interpretive dilemmas extend beyond the status accorded client memorial reports to therapists’ memory‐making practices as textualized via both supervision and clinical notetaking. Drawing on more recent (including feminist) discussions of memory that identify different political possibilities within third and first person accounts it was suggested that, rather than eschewing the subjectivity of memory, therapists can instead analyse this as a key interpretive and reflexive resource to inform their own practice.
EVALUATION OF OUTCOME IN A DYNAMICALLY ORIENTATED GROUP FOR ADULT MALES WHO HAVE BEEN SEXUALLY ABUSED IN CHILDHOOD
Authors: Morrison Audrey , Treliving Linda 
Published: November 2006

ABSTRACT
At a time when males abused in childhood are coming increasingly to attention of clinical services, we review the literature, describe the process and report on clinical outcomes of a slow open long‐term dynamically orientated group for abused adult males. Twenty‐nine men referred to the local psychotherapy service for consideration for inclusion in the group are discussed along with some of the most prevailing themes, namely identification with the aggressor, self‐esteem, guilt and sexuality. Symptoms were measured using the SCL 90‐R and demonstrate relatively high levels of psychological distress in this group at initial assessment. There is significant improvement in global scores, interpersonal sensitivity, depression and psychoticism in the group of 13 men who engaged in therapy for at least six months compared with those who did not.The authors conclude that symptom measurement provides evidence that group psychotherapy is a useful therapeutic approach in a group of men who might otherwise be considered unsuitable for psychotherapeutic interventions due to symptom severity and personality difficulties.
CONNECTION AND CATASTROPHE, HOPE AND DESPAIR IN OUR BORDERLINE WORLD
Authors: Campling Penelope 
Published: November 2006

ABSTRACT
Despair is the absence of connections or the severance of connections and the consequent sense of emptiness and impotence. Hope is about connecting, relating, being part of a healthy matrix and the consequent sense of agency that can come from this.This talk explores the particular quality of disconnectedness in our more disturbed patients where hope and despair move in cycles without any sense of a functioning centre that can keep hold of the pieces and understand how they fit together. Parallels are drawn between our patients' internal worlds and the external world in which we are located and work.Developing a sense of personal agency within a meaningful social matrix in a therapeutic community is contrasted to the state where the organization is always on the edge of unpredictable catastrophe and patients remain in a condition of despairing helplessness.
ASSESSMENT FOR COUPLE PSYCHOANALYTIC PSYCHOTHERAPY
Authors: Lanman Monica 
Published: November 2006

ABSTRACT
A therapist assessing with a view to couple psychoanalytic psychotherapy needs to hold several potentially conflicting points of view in mind simultaneously. Firstly the therapist attends to the experience of the session as an interaction with the ‘shared internal world’ of the couple, in the present, seeking to understand the dynamic meaning of whatever happens in the course of the meeting. At the same time the assessor needs to explore the question of appropriateness of different possible treatments, which may necessitate explicitly seeking certain kinds of information, relating, for example, to early experience or to risk assessment.The various points of view can be felt to be in conflict with each other, and I suggest that different parts of this complex enterprise are unfamiliar to, and may be neglected by different professional groups.
BODY HATRED
Authors: Parker Rozsika 
Published: November 2006

ABSTRACT
Body dysmorphic disorder is described and extended to cover both acute and mild cases of body hatred, in order to problematize a condition that Western culture normalizes. It is argued that contemporary Western culture does not cause BDD but provides a matrix within which it can flourish. The features of the culture that impact upon the condition are explored with particular emphasis given to the fear both of difference and of heterogeneity.In terms of the individual, the origins of the condition are located in the early imposition of transgenerational shame, elaborated, usually at adolescence, into body hatred. The perceived bodily defect is then experienced as encapsulated unacceptability. It is suggested that the selection of a body part for hatred be understood as a desperate effort to conceal and, paradoxically, to heal shame.The specific challenges in working psychotherapeutically with shame‐driven BDD are discussed; the demands made of the psychotherapist by the rituals associated with BDD, the stress on the psychotherapist's relationship with their own body and the significance of language used in addressing body hatred.
The Tumor Suppressor KLF11 Mediates a Novel Mechanism in Transforming Growth Factor β–Induced Growth Inhibition That Is Inactivated in Pancreatic Cancer
Authors: Buck Anita , Buchholz Malte , Wagner Martin , Adler Guido , Gress Thomas , Ellenrieder Volker 
Published: November 2006

Abstract
c-myc promoter silencing is a key step in epithelial cell growth inhibition by transforming growth factor β (TGFβ). During carcinogenesis, however, epithelial cells escape from c-myc repression and consequently become refractory to TGFβ-mediated antiproliferation. Here, we assessed the role of the repressor, KLF11, in TGFβ-induced growth inhibition in normal epithelial as well as pancreatic carcinoma cells. Endogenous KLF11 was stably down-regulated by RNA interference technology, and the functional consequences were studied by proliferation assays, reporter assays, DNA binding studies, and expression analyses. Coimmunoprecipitation and glutathione S-transferase pulldown assays were conducted to define KLF11-Smad3 interaction and U0126 was administered to examine the effects of the extracellular signal-regulated kinase (ERK)–mitogen-activated protein kinase on complex formation and c-myc promoter binding of KLF11 and Smad3 in pancreatic cancer cells. In TGFβ-stimulated normal epithelial cells, nuclear KLF11, in concert with Smad3, binds to and represses transcription from the core region of the TGFβ-inhibitory element (TIE) of the c-myc promoter. Disruption of KLF11-Smad3 interaction or small interfering RNA–mediated knockdown of endogenous KLF11 strongly diminishes Smad3-TIE promoter binding and repression, and consequently impairs TGFβ-mediated growth inhibition. In pancreatic cancer cells with oncogenic Ras mutations, hyperactive ERK counteracts TGFβ-induced c-myc repression and growth inhibition through at least two mechanisms, i.e., via disruption of KLF11-Smad3 complex formation and through inhibition of KLF11-Smad3 binding to the TIE element. Together, these results suggest a central role for KLF11 in TGFβ-induced c-myc repression and antiproliferation and identifies a novel mechanism through which ERK signaling antagonizes the tumor suppressor activities of TGFβ in pancreatic cancer cells with oncogenic Ras mutations. (Mol Cancer Res 2006;4(11):861–72)
Lipocalin 2 Antagonizes the Proangiogenic Action of Ras in Transformed Cells
Authors: Venkatesha Shivalingappa , Hanai Jun-ichi , Seth Pankaj , Karumanchi S. Ananth , Sukhatme Vikas P. 
Published: November 2006

Abstract
Lipocalin 2 is an iron-binding secreted protein that converts embryonic kidney mesenchyme to epithelia. Previously, we reported that lipocalin 2 could revert 4T1-ras-transformed mesenchymal tumor cells to a more epithelial phenotype, increase E-cadherin expression, and suppress cell invasiveness in vitro and in vivo, indicating that lipocalin 2 is a metastasis suppressor. Here, we show that lipocalin 2 can suppress the ras-induced expression of vascular endothelial growth factor in 4T1 cells via down-regulation of ras mitogen-activated protein kinase and ras phosphatidylinositol-3-kinase signaling. In addition, the expression of thrombospondin-1 (an antiangiogenic molecule) was increased in tumors formed by 4T1-ras cells into which lipocalin 2 was stably introduced. Tumor angiogenesis, assessed via an intradermal tumor angiogenesis assay, was also suppressed by lipocalin 2. We also show that caveolin-1 is a critical mediator of this activity. These data provide new insights into the action of lipocalin 2 and raise the possibility that the administration of lipocalin 2 may be useful for inhibiting tumor angiogenesis, in addition to suppressing tumor metastasis, in cancers which show ras activation. (Mol Cancer Res 2006;4(11):821–9)
Enhanced Expression of LKB1 in Breast Cancer Cells Attenuates Angiogenesis, Invasion, and Metastatic Potential
Authors: Zhuang Zhi-Gang , Di Gen-Hong , Shen Zhen-Zhou , Ding Jian , Shao Zhi-Ming 
Published: November 2006

Abstract
LKB1 (also known as STK11) is a recently identified tumor suppressor gene whose mutation can lead to Peutz-Jeghers syndrome, which is characterized by gastrointestinal polyps and cancers of different organ systems. Approximately 30% of sporadic breast cancer samples express low levels of LKB1. This suggests that the LKB1 gene may be related to the tumorigenesis of breast cancer. We reintroduced LKB1 into MDA-MB-435 breast cancer cells that lack the LKB1 gene to investigate how overexpression of LKB1 affects tumor invasiveness and metastasis. Overexpression of the LKB1 protein in breast cancer cells resulted in significant inhibition of in vitro invasion. In vivo, LKB1 expression reduced tumor growth in the mammary fat pad, microvessel density, and lung metastasis. LKB1 overexpression was associated with down-regulation of matrix metalloproteinase-2, matrix metalloproteinase-9, vascular endothelial growth factor, and basic fibroblast growth factor mRNA and protein levels. Overexpression of the LKB1 protein in human breast cancer is significantly associated with a decrease in microvessel density. Our results indicate that LKB1 plays a negative regulatory role in human breast cancer, a finding that may lead to a new therapeutic strategy. (Mol Cancer Res 2006;4(11):843–9)
Down Syndrome Candidate Region 1 Isoform 1 Mediates Angiogenesis through the Calcineurin-NFAT Pathway
Authors: Qin Liuliang , Zhao Dezheng , Liu Xin , Nagy Janice A. , Hoang Mien Van , Brown Lawrence F. , Dvorak Harold F. , Zeng Huiyan 
Published: November 2006

Abstract
Down syndrome candidate region 1 (DSCR1) is one of more than 50 genes located in a region of chromosome 21 that has been implicated in Down syndrome. DSCR1 can be expressed as four isoforms, one of which, isoform 4 (DSCR1-4), has recently been found to be strongly induced by vascular endothelial growth factor A (VEGF-A165) and to provide a negative feedback loop that inhibits VEGF-A165-induced endothelial cell proliferation in vitro and angiogenesis in vivo. We report here that another DSCR1 isoform, DSCR1-1L, is also up-regulated by VEGF-A165 in cultured endothelial cells and is strongly expressed in several types of pathologic angiogenesis in vivo. In contrast to DSCR1-4, the overexpression of DSCR1-1L induced the proliferation and activation of the transcription factor NFAT in cultured endothelial cells and promoted angiogenesis in Matrigel assays in vivo, even in the absence of VEGF-A. Similarly, small interfering RNAs specific for DSCR1-1L and DSCR1-4 had opposing inhibitory and stimulatory effects, respectively, on these same functions. DSCR1-4 is thought to inhibit angiogenesis by inactivating calcineurin, thereby preventing activation and nuclear translocation of NFAT, a key transcription factor. In contrast, DSCR1-1L, regulated by a different promoter than DSCR1-4, activates NFAT and its proangiogenic activity is inhibited by cyclosporin, an inhibitor of calcineurin. In sum, DSCR1-1L, unlike DSCR1-4, potently activates angiogenesis and could be an attractive target for antiangiogenesis therapy. (Mol Cancer Res 2006;4(11):811–20)
MUC1 Oncoprotein Functions in Activation of Fibroblast Growth Factor Receptor Signaling
Authors: Ren Jian , Raina Deepak , Chen Wen , Li Guilan , Huang Lei , Kufe Donald 
Published: November 2006

AbstractActivation of the fibroblast growth factor (FGF) receptor 3 (FGFR3) has been linked to the development of human cancers by mechanisms that are not well understood. The MUC1 oncoprotein is aberrantly overexpressed by certain hematologic malignancies and most human carcinomas. The present studies show that MUC1 associates with FGFR3. Stimulation of cells with FGF1 increased the interaction between MUC1 and FGFR3. FGF1 stimulation also induced c-Src-dependent tyrosine phosphorylation of the MUC1 cytoplasmic domain on a YEKV motif. FGF1-induced tyrosine phosphorylation of MUC1 was associated with increased binding of MUC1 to β-catenin and targeting of MUC1 and β-catenin to the nucleus. FGF1 also induced binding of MUC1 to the heat shock protein 90 (HSP90) chaperone by a mechanism dependent on phosphorylation of the YEKV motif. Notably, β-catenin and HSP90 compete for binding to the MUC1 cytoplasmic domain, indicating that MUC1 forms mutually exclusive complexes with these proteins. The results also show that inhibition of HSP90 with geldanamycin or 17-(allylamino)-17-demethoxygeldanamycin attenuates FGF1-induced binding of MUC1 to HSP90 and targeting of MUC1 to the mitochondrial outer membrane. These findings indicate that FGF1 induces phosphorylation of MUC1 on YEKV and thereby activates two distinct pathways: (a) nuclear localization of MUC1 and β-catenin and (b) delivery of MUC1 to mitochondria by HSP90. (Mol Cancer Res 2006;4(11):873–83)
Regulation of Thromboxane Receptor Trafficking Through the Prostacyclin Receptor in Vascular Smooth Muscle Cells
Authors: Wilson Stephen J. , Dowling Jennifer K. , Zhao Lei , Carnish Erin , Smyth Emer M. 
Published: November 2006

Background—Prostacyclin (PGI2) and thromboxane (TxA2) effect disparate outcomes for atherogenesis and the response to vascular injury; PGI2, a vasodilator and inhibitor of platelet aggregation, limits the deleterious actions of TxA2, a vasoconstrictor and platelet activator. Dimerization of their G protein-coupled receptors, IP and TP, evokes a modified cellular response through which IP/TP counter-balance may be effected. We examined the consequence of IP/TP interaction for the regulatory pathways of both receptors.Methods and Results—TPα overexpressed in HEK293 cells or expressed endogenously in aortic smooth muscle cells (ASMCs) was internalized after selective activation of either TP or IP. Homologous trafficking of TP was unaltered by coexpression of IP. Heterologous sequestration of TPα required the physical presence of activated IP, in transfected and native cells, but was independent of IP signaling to adenylyl cyclase. Reciprocal heterologous regulation of IP, via activated TP, was evident in both HEK293 cells and ASMCs. Homologous TP internalization led to receptor retention and degradation. In contrast, when internalization was IP-induced, TPα was recycled to the cell surface in coexpressing HEK293 cells, but not in ASMCs, in accord with the postendocytotic pathway of IP.Conclusions—IP/TPα interaction permits reciprocal regulation of receptor endocytosis via the trafficking pathway determined by the activated dimeric partner.
Expression of a non–DNA-binding isoform of Helios induces T-cell lymphoma in mice
Authors: Zhang Zheng , Swindle C. Scott , Bates John T. , Ko Rose , Cotta Claudiu V. , Klug Christopher A. 
Published: November 2006

AbstractHelios is a zinc-finger protein belonging to the Ikaros family of transcriptional regulators. It is expressed, along with Ikaros, throughout early stages of thymocyte development where it quantitatively associates with Ikaros through C-terminal zinc-finger domains that mediate heterodimerization between Ikaros family members. To understand the role of Helios in T-cell development, we used a retroviral vector to express full-length Helios or a Helios isoform that lacked the N-terminal DNA-binding domain in hematopoietic progenitor cells of reconstituted mice. Constitutive expression of full-length Helios resulted in an inhibition of T-cell development at the double-negative stage within the thymus. Although expression of the DNA-binding mutant of Helios did not contribute to developmental abnormalities at early times after transplantation, 60% of animals that expressed the Helios DNA-binding mutant developed an aggressive and transplantable T-cell lymphoma 4 to 10 months after transplantation. These results demonstrate a vital function for Helios in maintaining normal homeostasis of developing T cells and formally show that non–DNA-binding isoforms of Helios are lymphomagenic if aberrantly expressed within the T-cell lineage.
Granulocyte-stimulating factor and severe aplastic anemia: a survey by the European Group for Blood and Marrow Transplantation (EBMT)
Authors: Socie Gerard , Mary Jean-Yves , Schrezenmeier Hubert , Marsh Judith , Bacigalupo Andrea , Locasciulli Anna , Fuehrer Monica , Bekassy Albert , Tichelli Andre , Passweg Jakob 
Published: November 2006

Abstract
Previous studies suggested a link between the use of G-CSF and increased incidence of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) after immunosuppressive therapy (IST) for severe aplastic anemia (SAA). This European survey included 840 patients who received a first-line IST with (43%) or without (57%) G-CSF. The incidences of MDS/AML in patients who did or did not receive G-CSF were 10.9% and 5.8%, respectively. A significantly higher hazard (1.9) of MDS/AML was associated with use of G-CSF. Relapse of aplastic anemia was not associated with a worse outcome in patients who did not receive G-CSF as first therapy, whereas relapse was associated with a significantly worse outcome in those patients who received G-CSF. These results emphasize the necessity of the current European randomized trial comparing IST with or without G-CSF and to alert physicians that adding G-CSF to IST is currently not standard treatment for SAA.