bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Association Between Social Connectedness and Psychological Well‐Being Among International Students: Social Support Moderates the Mediating Effects of Loneliness and Perceived Stress
Authors: Tang Lingjie , Zhang Chang'an , Cui Yu 
Published: February 2025

ABSTRACTThe current study aimed to investigate the connection between social connectedness and psychological well‐being (PWB), while concurrently exploring the potential mediating roles of loneliness and perceived stress in this relationship among international students in China. Drawing on the literature highlighting the protective effect of social support, this study also sought to explore whether social support played a moderating role in the loneliness‐ and perceived stress‐PWB relationships. The sample comprised 530 students (43.4% of females), aged between 18 and 31 years (M = 24.39, SD = 4.12), and enrolled in various academic disciplines. Findings of the mediation model indicated that loneliness and perceived stress mediated the relationship between social connectedness and students' PWB. Additionally, moderation analyses revealed that social support had a significant moderating effect such that the negative associations between loneliness/perceived stress and PWB became non‐significant or weaker for international students with high levels of social support. Furthermore, the indirect effects of social connectedness on PWB was also found to be significantly moderated by varying social support levels. Limitations and recommendations for future studies as well as implications for practice are also discussed.
Release of ‘Essekerka’, a high yielding winter wheat cultivar with good grain and flour quality
Authors: Spanic Valentina , Hefer Dubravka , Dvojkovic Kresimir 
Published: February 2025

Abstract‘Essekerka’ (Reg. no. CV‐1211, PI 704099), hard red winter wheat (Triticum aestivum L.) was developed by the Agricultural Institute Osijek (Croatia) and released in 2023. Essekerka was derived from the cross ‘Irishka’ × ‘Apache’. It was tested under experimental number Osk.4.354/12‐18 and showed high grain yield with enhanced dough quality in trials (2019–2022) based on farinograph analysis. Essekerka has grain yield comparable to two high‐yielding hard red winter wheat check cultivars (Apache and ‘Kraljica’). Essekerka has higher grain yield than hard red winter wheat cultivar ‘Viktorija’ which is declared as check for quality. Overall, better Fusarium head blight resistance was observed in Essekerka than in ‘Vikotrija’. Compared with one of the parent Apache, in various trials Essekerka matured 2–3 days earlier and was 2‐ to 3‐cm shorter.
Comparative Proteomics of Salinity Stress Responses in Fish and Aquatic Invertebrates
Authors: Leprêtre Maxime , Hamar Jens , Urias Monica B. , Kültz Dietmar 
Published: February 2025

ABSTRACTFluctuating salinity is symptomatic of climate change challenging aquatic species. The melting of polar ice, rising sea levels, coastal surface and groundwater salinization, and increased evaporation in arid habitats alter salinity worldwide. Moreover, the frequency and intensity of extreme weather events such as rainstorms and floods increase, causing rapid shifts in brackish and coastal habitat salinity. Such salinity alterations disrupt homeostasis and ultimately diminish the fitness, of aquatic organisms by interfering with metabolism, reproduction, immunity, and other critical aspects of physiology. Proteins are central to these physiological mechanisms. They represent the molecular building blocks of phenotypes that govern organismal responses to environmental challenges. Environmental cues regulate proteins in a concerted fashion, necessitating holistic analyses of proteomes for comprehending salinity stress responses. Proteomics approaches reveal molecular causes of population declines and enable holistic bioindication geared toward timely interventions to prevent local extinctions. Proteomics analyses of salinity effects on aquatic organisms have been performed since the mid‐1990s, propelled by the invention of two‐dimensional protein gels, soft ionization techniques for mass spectrometry (MS), and nano‐liquid chromatography in the 1970s and 1980s. This review summarizes the current knowledge on salinity regulation of proteomes from aquatic organisms, including key methodological advances over the past decades.
Telerehabilitation of patients with stroke: Initial program theories for successful implementation
Authors: Hasan Mohamed M. , Rafferty Miriam R. , Roth Elliot , Abunaser Sarah , Smith Justin D. , Hirschhorn Lisa R. , Woods Donna 
Published: February 2025

AbstractPurposeTelerehabilitation has proven effective for stroke survivors, yet it is slowly implemented. We developed Initial Program Theories (IPTs) that focus on the telerehabilitation of stroke survivors in the United States to uncover the possible causal relationship between implementation strategies and outcomes.MethodsWe created a conceptual framework to steer the development of IPTs. Then, we extracted concepts from theoretical frameworks reported in telemedicine implementation literature combined with feedback meetings with stakeholders with relevant experience.ResultsWe developed a framework for implementing telerehabilitation that includes implementation levels, contextual domains, telerehabilitation technology, implementation phases, actors, targets, mechanisms, and outcomes. We created 27 IPTs that specify telerehabilitation interventions, implementation strategies, actors, targets, context, implementation mechanisms, and outcomes. The IPTs were refined and validated through feedback meetings.ConclusionsThis study adds to the relatively scarce literature on IPT development. For each IPT, we elaborated on the implementation mechanism and how it could facilitate or hinder telerehabilitation implementation, an essential insight for researchers and professionals to plan successful implementation strategies. Understanding causal mechanisms helps identify implementation strategies that will work in the U.S. context and improve weak implementation strategies that are potentially significant or commonly used.
Periselectivity, Chemoselectivity, and Regioselectivity of the Cycloaddition Reaction of Aza‐Oxyallyl Cations With Cinnamaldehyde: A Density Functional Theory Study
Authors: Adusei Godfred Boakye , Aniagyei Albert , Menkah Elliot , Kwawu Caroline R. , Amankwah Gabriel , Arhin Richmond , Osman Hawa , Adei Evans 
Published: February 2025

ABSTRACTThis study theoretically investigates the factors controlling the periselectivity, chemoselectivity, and regioselectivity of the [3 + 2] cycloaddition reaction of aza‐oxyallyl cation with cinnamaldehyde to form oxazolidinone. The research utilizes hybrid density functional theory (DFT) method at the B3LYP‐D3, B3LYP, M06, and M062X coupled with the 6‐311G (d, p) level of theories to explain that the [3 + 2] chemoselective addition of aza‐oxyallyl cation across the carbonyl bond of cinnamaldehyde through its C and N reactive sites is more favorable than any other plausible mechanism. Generally, electron‐donating groups (EDGs) on aza‐oxyallyl cation decrease the activation barriers, whereas electron‐withdrawing groups (EWGs) increase the activation barrier. The GEDT values predict a very low polar reaction for the [3 + 2] cycloaddition reaction.
Multi‐Responsive Nanogels Based on Sulfoxide Polymethacrylates for Biomedical Applications
Authors: Stauber Hannah Elodie , López‐Iglesias Clara , Kanwal Sidra , Quaas Elisa , Klinger Daniel 
Published: February 2025

ABSTRACTNanogels for biomedical applications require polymeric building blocks that show high hydrophilicity and (thermo‐)responsive properties without immune response risks. Polysulfoxides offer these advantages but have not yet been translated to 3‐dimensional colloidal materials. To examine their potential as alternatives to established systems, we developed a synthetic platform with synthetic control and chemical versatility. For this, we utilize the thermo‐responsive properties of a polymethacrylate with propyl sulfoxide side groups, that is, poly(2‐(n‐propyl‐sulfoxide)ethyl methacrylate) (P(nPr‐SEMA)). Its phase transition near body temperature enables nanogel preparation via conventional precipitation polymerization in an all‐aqueous system. To fully assess this approach's potential, we first demonstrate control over colloidal properties like size, size distribution, and crosslinking density. We examine the influence of these parameters on the temperature‐dependent swelling profiles and develop a standard synthetic protocol. Second, we examine synthetic versatility to introduce additional stimuli‐responsiveness. For this, we introduce methacrylic acid (MAA) as pH‐responsive co‐monomer and examine resulting double‐sensitive swelling. Third, we add network degradability through reduction‐cleavable crosslinker bis(2‐methacryloyloxyethyl) disulfide (DSDMA). Fourth, we demonstrate that multi‐responsive nanogels exhibit low cytotoxicity and high colloidal stability in biologically relevant media. Overall, this systematic study establishes P(nPr‐SEMA)‐based nanogels as versatile alternatives to established temperature‐responsive nanogels for biomedical applications, for example, drug delivery.
Effect of Symptom Burden on Demoralization in Chinese Lung Cancer Patients: The Mediating Roles of Family Function, Resilience, and Coping Behaviors
Authors: Zhang Chenxing , Wang Fangfang , Kang Zhixuan , Hong Yuting , Arbing Rachel , Chen Wei‐Ti , Huang Feifei 
Published: February 2025

ABSTRACTObjectiveThis study aimed to elucidate the mechanisms by which symptom burden affects demoralization in Chinese lung cancer patients, with a focus on the roles of family functionality, resilience, and coping strategies. The study also explored differences in these pathways between two distinct demoralization categories.MethodsA cross‐sectional survey was conducted among 567 lung cancer patients who completed questionnaires assessing symptom burden, family functioning, resilience, coping strategies, and demoralization. Data were analyzed using partial least squares structural equation modeling (PLS‐SEM), with multigroup structural equation modeling (MG‐SEM) employed to compare pathways between the psychological distress‐subjective incompetence group (PDSIG) and the low demoralization‐emotional disturbance group (LDEDG).ResultsPLS‐SEM analysis demonstrated a good model fit. Symptom burden (β = 0.26), confrontation coping (β = 0.11), and acceptance‐resignation coping (β = 0.41) had positive direct effects on demoralization, whereas resilience (β = −0.19) and family function (β = −0.27) had negative direct effects. Additionally, family function, resilience, and acceptance‐resignation coping mediated the relationship between symptom burden and demoralization. MG‐SEM revealed that, in the PDSIG, symptom burden (β = 0.47) and family function (β = −0.46) had similarly strong impacts on demoralization, with stronger family function associated with lower demoralization. In contrast, resilience (β = −1.02) was the most significant factor in the LDEDG.ConclusionsThese findings highlight the importance of screening for demoralization, particularly among lung cancer patients with a high symptom burden, maladaptive resignation coping, family dysfunction, and low resilience. Effective strategies should focus on symptom management, family support, resilience building, and fostering positive coping mechanisms. Tailored interventions based on demoralization subtypes are essential to improve psychological well‐being in this population.
Genomics and morphometry of herbarium specimens elucidate the origin of the Cape Verde date palm (Phoenix atlantica A.Chev.) and highlight its agronomic potential
Authors: Cid‐Vian Jerónimo , Pérez‐Escobar Oscar A. , Baker William J. , Bonhomme Vincent , Ferrand Sylvie , Ivorra Sarah , Kaczmarek Thomas , Pagnoux Clémence , Terral Jean‐Frédéric , Wales Nathan , Purugganan Michael D. , Creer Simon , Papadopulos Alexander S. T. , Bellot Sidonie , Gros‐Balthazard Muriel 
Published: February 2025

Societal Impact StatementAs climate change accelerates, breeding resilient crops is urgent. The date palm (Phoenix dactylifera L.), a crucial 18 billion USD fruit crop, underpins North African and West Asian oasis agroecosystems. This study investigates the genetics and morphology of its closest wild relative, the endemic and endangered Cape Verde date palm (Phoenix atlantica A.Chev.). We reveal that the latter originated through a feralisation process from domesticated date palms, evolving back into a wild state with unique genetic diversity. This highlights the need to protect its distinctiveness and opens the possibility of enhancing date palm resilience through its inclusion in breeding programs.Summary
The date palm (Phoenix dactylifera L.). is a major crop but its sustainability is threatened by climate change. This challenge could be mitigated by breeding with wild relatives or feral populations. The endangered and endemic Cape Verde date palm (Phoenix atlantica A.Chev.) is thought to be among the closest relatives of the date palm, but its origin and taxonomic status remain unclear, with studies having recovered it either as a separate species or a feral date palm. Better understanding the differentiation of P. atlantica and P. dactylifera is needed to fully unlock the potential of the Cape Verde date palm as a candidate for date palm improvement.
In this study, we employ an integrative approach to clarify the origin of P. atlantica. Specifically, we investigate the phylogenetic placement, genetic structure, and seed morphology of P. atlantica by generating extensive genomic and seed morphology datasets from expert‐verified historical and modern specimens of Phoenix, including the type specimen of P. atlantica.
Our findings indicate that P. atlantica is monophyletic but nested within P. dactylifera. Its genetic diversity overlaps substantially but not completely with North African date palm varieties, and its seeds share characteristics with those of cultivated and feral date palms, notably elongation, a trait linked to domestication.
These results suggest that P. atlantica may be an incipient species that originated from a date palm feralisation event. We emphasise the need for conserving its natural genetic variation and the traditional knowledge associated with its name to support breeding programs.
Mesoscopic Damage Evolution of Hydroxyl‐Terminated Polybutadiene Propellants under Biaxial Tension
Authors: Yuan Bin , Qiang Hongfu , Wang Xueren , Chen Tiezhu , Yue Chunguo 
Published: February 2025

ABSTRACTThis study conducted systematic in‐situ tensile scanning tests on hydroxyl‐terminated polybutadiene (HTPB) propellant under biaxial tensile conditions. It successfully acquired in‐situ experimental data at different tensile ratios. Through in‐depth analysis of the experimental data, the study elucidated the damage evolution mechanism of HTPB propellant specimens during the biaxial tensile process. The research utilized advanced imaging techniques to visually analyze the mesoscopic damage evolution process of two‐dimensional slices of the solid fuel, with porosity being used as a key indicator of damage variables for the quantitative description of the damage process under biaxial tensile. The study combined statistical principles with damage theory to derive a damage evolution equation describing the change of porosity with strain. A detailed comparative analysis between the theoretical model and experimental results validated the correctness and feasibility of the damage evolution equation, providing a new theoretical basis and method for damage assessment of solid propellants under complex stress states. This study enriches the understanding of the mechanical behavior of HTPB propellants and offers significant experimental data and theoretical models for research in related fields.
The Crystal Structure of the Domain of Unknown Function 1480 (DUF1480) From Klebsiella pneumoniae
Authors: Patel Dhruvin H. , Watanabe Nobuhiko , Savchenko Alexei , Semper Cameron 
Published: February 2025

ABSTRACTDomains of unknown function (DUFs) continue to comprise a significant portion of bacterial proteomes, with more than 20% of bacterial proteins remaining annotated as DUFs. The characterization of their molecular structure can provide valuable insight that is not captured by the primary sequence analysis, thus providing a segue into the identification of the molecular function of DUF representatives. Here, we present the crystal structure of KPN_02352 from Klebsiella pneumoniae subsp. pneumoniae, a DUF1480 domain‐containing protein, which was determined to be 1.75 Å resolution. Representatives of the DUF1480 family are found broadly across Enterobacterales and have been previously shown to contribute to the antibiotic response. Our structural analysis suggests that DUF1480 is comprised of a six‐stranded split barrel fold featuring a small alpha helix that is positioned to cap one end of the split barrel. DUF1480 was found to be monomeric in solution, and harbors structural similarity to response regulators. The crystal structure of DUF1480 is the first experimental insight into the molecular structure of this conserved protein family, revealing several conserved features that may be functionally relevant.
Sources, identification, and behavioral significance of oviposition‐deterring pheromones in insects
Authors: Zhang Xiaxuan , Wang Guirong 
Published: February 2025

AbstractOviposition is a pivotal activity for female insects, significantly influencing their fitness and the survival of their offspring. Selecting an optimal oviposition site ensures the successful development of progeny and minimizes inter‐ and intraspecific competition. This selection process relies heavily on multimodal sensory inputs, with olfaction cues playing a central role. Among these chemical signals, oviposition‐deterring pheromones (ODPs) have garnered considerable attention for their ability to modulate oviposition behaviors and facilitate both inter‐ and intraspecific communication. ODPs, secreted by insects from various orders such as Lepidoptera, Coleoptera, and Diptera, are key regulators of population density, resource competition, and ecological balance. These pheromones also assist parasitic wasps in host location, targeting eggs or larvae. Given their profound impact on insect behavior, ODPs present promising applications in pest management strategies and are expected to be used for the development of new pest control methods. This review examines the sources, chemical composition, and biological significance of ODPs across insect species and explores their potential in controlling insect populations. © 2025 Society of Chemical Industry.
Exploring the influence of habitat, ground refugia and behavioral strategies on the overwintering success of Drosophila suzukii, Matsumura
Authors: Shrestha Binita , Stockton Dara G , Hesler Stephen P , Loeb Gregory M 
Published: February 2025

AbstractBACKGROUNDThe overwintering biology of Drosophila suzukii is poorly understood. While thermal tolerance studies suggest that winter morphotype females likely survive harsh winters given physiological changes that lead to cold‐hardening, additional factors such as habitat selection are likely important but poorly understood. In the present study, we conducted a field study at three vineyard sites to investigate winter habitat selection, a semi‐field study to measure survival outcomes depending on various ground refugia, and a laboratory study to evaluate vertical movement in response to simulated flood conditions often observed in winter.RESULTSOur results showed three things. First, Drosophila suzukii was most abundant in wooded areas of vineyards and near pomace piles. Few were captured in the vineyard itself and even fewer were captured in the winery facilities. Second, insulating ground cover such as straw was beneficial to improving survivability. Third, while insulating ground cover was beneficial during stable periods below freezing, during warm‐up periods where snow melts and subsequently floods the ground, fly mobility and vertical movement was critical for survival.CONCLUSIONCold acclimated flies are active participants in their environment, even at freezing temperatures, navigating changing landscape features and adjusting their position in response to temperature and ground conditions. Our data showed for the first time that cold acclimated flies are capable of vertical movement even at freezing temperatures as water levels rise at the ground level during thaw events. Thus, the overwintering behavior and ecology of D. suzukii is more complex than previously thought, and there are likely several factors in addition to physiological cold hardening that contribute to overwintering success. © 2025 Society of Chemical Industry.
The Potential Mechanism of Soy Isoflavones in Treating Osteoporosis: Focusing on Bone Metabolism and Oxidative Stress
Authors: Zhou Yuanyuan , Su Zhan , Liu Gang , Hu Siwang , Chang Jiang 
Published: February 2025

ABSTRACTOsteoporosis is divided into primary and secondary types. Primary osteoporosis may result from estrogen deficiency in postmenopausal women, imbalanced bone remodeling in the elderly, or imbalanced adolescent—type bone development. Secondary osteoporosis can be caused by factors like long—term glucocorticoid treatment, chronic kidney disease (CKD), estrogen deprivation, oxidative stress, diabetes, and obesity. This review focuses on the therapeutic potential of soy isoflavones for osteoporosis. At the cellular level, soy isoflavones, as natural plant extracts and phytoestrogens, are crucial for osteoblastogenesis and differentiation, osteoclastogenesis, osteoclast mineralization, and bone marrow mesenchymal stromal cell differentiation. They also maintain calcium homeostasis by regulating extracellular calcium and vitamin D levels. In terms of oxidative stress, soy isoflavones mitigate it in the endoplasmic reticulum and mitochondria, thus regulating cellular senescence, autophagy, and bone remodeling processes. Moreover, soy isoflavones can relieve symptoms related to CKD and inhibit glucocorticoid secretion, which directly or indirectly benefits the treatment of osteoporosis. Overall, soy isoflavones have the potential to treat osteoporosis by enhancing bone health, regulating metabolism, and alleviating oxidative stress. Future research should explore the potential of soy isoflavones as phytoestrogens for treating osteoporosis. This exploration should focus on clarifying the safety, identifying potential side effects, determining the optimal dosage regimen, and developing strategies to mitigate any adverse reactions. In addition, further large‐scale, multicenter human clinical trials are necessary to accurately evaluate the actual therapeutic effect of soy isoflavones on osteoporosis.
Endobronchial Lipoma Causing Almost Completely Trachea Obstruction
Authors: He Gaoyan , Zhao Jie , Wu Xiaojuan , Li Bo , Luo Xiaobin , Zhu Tao 
Published: February 2025

ABSTRACTEven though endobronchial lipoma is rare, it can mimic malignancy and lead to significant complications such as progressive dyspnea and subsequent lung infections related to endobronchial obstruction. We present a case of endobronchial lipoma located in the trachea causing almost complete tracheal obstruction. The patient's dyspnea disappeared after undergoing bronchoscopic excision of the mass.