bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Design of Chiral Bifunctional Secondary Amine Catalysts for Asymmetric Enamine Catalysis
Authors: Kano Taichi , Maruoka Keiji 
Published: January 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Organocatalytic Enantioselective Reduction of Olefins, Ketones, and Imines
Authors: Kagan Henri B. 
Published: January 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Asymmetric Acyl Transfer Reactions
Authors: Spivey Alan C. , McDaid Paul 
Published: January 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Imino‐C‐disaccharides and Analogues: Synthesis and Biological Activity
Authors: Vogel Pierre , Gerber‐Lemaire Sandrine , Juillerat‐Jeanneret Lucienne 
Published: January 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: 6‐Membered P‐Heterocycles: Ring‐Condensed 1,3,2‐Diheterophosphorinane 2‐Chalcogenides
Authors: Frank Eva , Wolfling Janos 
Published: January 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Advances in the Development of Methods for the Synthesis of Antihypertensive Drugs (Angiotensin AT1 Antagonists)
Authors: Yet Larry 
Published: January 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: 2,3‐Dihydrothiophenes and Derivatives
Authors: Block Eric 
Published: January 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis by Substitution of Hydrogen
Authors: Hartung J. 
Published: January 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Alk‐1‐enyl Phosphorus Compounds
Authors: Gaumont A. C. , Gulea M. 
Published: January 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Consolidated Bioprocessing of Cellulosic Biomass to Ethanol Using Thermophilic Bacteria
Authors: Lynd Lee R. , Currie Devin , Ciazza Nicky , Herring Chris , Orem Nick 
Published: January 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Mechanistic Approaches to Palladium‐Catalyzed Alkene Difunctionalization Reactions.
Authors: Jensen Katrina H. , Sigman Matthew S. 
Published: January 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Simulations of Temperature and Pressure Unfolding of Peptides and Proteins with Replica Exchange Molecular Dynamics
Authors: Garcia Angel E. , Herce Henry , Paschek Dietmar 
Published: January 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Preconcentration and Separation Methods for the Determination of Trace Palladium in Environmental Samples
Authors: Krystyna Pyrzynska 
Published: January 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of 11C, 18F, 15O, and 13N Radiolabels for Positron Emission Tomography
Authors: Miller Philip W. , Long Nicholas J. , Vilar Ramon , Gee Antony D. 
Published: January 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Mass Spectrometry of Carbohydrates: Newer Aspects
Authors: Rodrigues Joao A. , Taylor Adrian M. , Sumpton David P. , Reynolds James C. , Pickford Russell , Thomas‐Oates Jane 
Published: January 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A phase 1/pilot study of radiofrequency ablation for the treatment of recurrent pediatric solid tumors
Authors: Hoffer Fredric A. , Daw Najat C. , Xiong Xiaoping , Anghelescu Doralina , Krasin Matthew , Yan Xiaowei , Davidoff Andrew M. , Furman Wayne L. , Rodriguez‐Galindo Carlos , Spunt Sheri L. 
Published: January 2009

AbstractBACKGROUND:This prospective study was designed to be the first to evaluate the toxicity of radiofrequency ablation (RFA) in patients with recurrent pediatric solid tumors.METHODS:From 2003 through 2008, a phase 1/pilot study of RFA for recurrent pediatric solid tumors was conducted. A multidisciplinary cancer management team selected appropriate candidates for the study. Imaging‐guided RFA was performed percutaneously. Repeat RFA was performed for recurrences when appropriate. Toxicity and imaging response was assessed at 1 month and 3 months prospectively. Accrual stopped in 2006, and data collection stopped in 2008.RESULTS:Sixteen patients (ages 4 years‐33 years; median age, 15 years) and 56 tumor sites were treated in 37 RFA sessions including 38 pulmonary, 11 musculoskeletal, and 7 hepatic lesions (82 lesion‐treatments). Postprocedural pain was moderate (median 5 on a scale from 1 to 10) and lasted a median of 9 days. Prolonged hospitalization (beyond 1 day) occurred 17 times (range, 2 days‐25 days; median, 3 days). Hypoxia supported by supplemental oxygen occurred in 8 of 16 patients and resolved within 1 month after each RFA. No patient had tumor lysis syndrome but myoglobinuria/hemoglobinuria occurred in 6 of 16 patients, all without renal damage. Serious complications from pulmonary RFA included 2 diaphragmatic hernias. Of 82 lesions imaged, 24 (29%) remained ablated at the end of the study.CONCLUSIONS:The toxicity from RFA of recurrent pediatric solid tumors was real but limited, and RFA may offer a local tumor control alternative in carefully selected cases. Cancer 2009. © 2009 American Cancer Society.
The use of reflex high‐risk human papillomavirus testing for atypical squamous cells of undetermined significance interpretations on vaginal specimens
Authors: Kendall Brian S. , Zahn Christopher M. 
Published: January 2009

AbstractBACKGROUND:The use of reflex high‐risk human papillomavirus (hrHPV) testing as a triage method for cervical specimens with an interpretation of atypical squamous cells of undetermined significance (ASC‐US) is well established. To the authors' knowledge, very little has been reported regarding the utility of this approach in vaginal specimens in women with a prior hysterectomy. The current study evaluated the results of hrHPV testing in women with vaginal specimens interpreted as ASC‐US in the authors' laboratory.METHODS:Follow‐up information, including results of hrHPV testing, was sought for all vaginal smears reported as ASC‐US from the authors' cytology laboratory during the calendar years 2005 and 2006.RESULTS:For the 2 years reviewed, 254 ASC‐US vaginal specimens were available for assessment. Reflex hrHPV testing was requested on 236 (92.9%), with sufficient residual material available in 193 specimens. hrHPV was detected in 44 (22.8%). Follow‐up results were available for 136 specimens, with a squamous intraepithelial lesion (SIL, all but 1 of which was low grade) found to be present in 21 (15.4%). SIL was identified in significantly more women in whom hrHPV was detected compared with those in whom hrHPV was not detected (41.9% vs 4.2%; P < .001 by the Fisher exact test).CONCLUSIONS:Rates of detection of squamous abnormalities in women with ASC‐US on vaginal preparations in whom hrHPV was detected were found to be higher than in those without hrHPV. These findings suggest that clinical follow‐up is needed for women in whom hrHPV is detected. hrHPV testing may be clinically useful as a method of triage for women with ASC‐US vaginal smears. Cancer (Cancer Cytopathol) 2009. Published 2009 by the American Cancer Society.
Proliferative rate in endoscopic ultrasound fine‐needle aspiration of pancreatic endocrine tumors
Authors: Alexiev Borislav A. , Darwin Peter E. , Goloubeva Olga , Ioffe Olga B. 
Published: January 2009

AbstractBACKGROUND:The objectives of this study were to evaluate the role of endoscopic ultrasonography (EUS)‐guided fine‐needle aspiration (FNA) in the preoperative diagnosis of pancreatic endocrine tumors (PETs) and to investigate whether the Ki‐67 index determined on cytologic material could help predict their behavior.METHODS:The study included 10 men and 5 women (ratio of men to women, 2:1) with a mean age of 62.4 years (range, 40‐79 years). Diff‐Quik‐ and Papanicolaou‐stained FNA samples were analyzed retrospectively, and immunocytochemical stains were performed for chromogranin A, synaptophysin, vimentin, α‐1‐antitrypsin, and Ki‐67 on cell block sections. The Ki‐67 index was evaluated by using digital image‐analysis software and was correlated with follow‐up (mean, 21.5 months; range, 2‐43 months).RESULTS:The overall survival was rate 86.7% (13 of 15 patients). Seven of 15 patients (46.7%) patients developed lymph node and/or hematogenous metastases. The Ki‐67 index in PETs with no metastases was lower (mean, 6.3%; range, 2%‐13%) than in clinically aggressive (metastatic) tumors (mean, 7.7%; range, 3%‐27%; P = .03). None of the tumors that had a Ki‐67 index ≤2% were metastatic. Both patients who died of disease had a Ki‐67 index of 4%.CONCLUSIONS:Although tumors with metastatic potential tended to exhibit a slightly higher Ki‐67 index, there was a significant overlap with nonmetastatic tumors, and PETs that had a very low proliferative rate still could behave aggressively; therefore, the authors concluded that the Ki‐67 index does not predict the risk of disease progression in patients with PETs. Cancer (Cancer Cytopathol) 2009. © 2009 American Cancer Society.
P63 differentiates subtypes of nonsmall cell carcinomas of lung in cytologic samples
Authors: Jorda Merce , Gomez‐Fernandez Carmen , Garcia Monica , Mousavi Fatemeh , Walker Gail , Mejias Aldo , Fernandez‐Castro Gustavo , Ganjei‐Azar Parvin 
Published: January 2009

AbstractBACKGROUND:Bevacizumab in combination with carboplatin and paclitaxel improves overall response and survival in patients with advanced or recurrent nonsmall cell lung carcinoma. However, this drug is not recommended in patients with squamous cell carcinoma or neoplasms with a dominant squamous component. Therefore, identification of squamous cell differentiation has therapeutic implications. In many instances, cytology is the diagnostic tool of choice; however, routine cytomorphology is limited in classification of nonsmall cell carcinomas into squamous and nonsquamous subtypes. The aim of this study was to identify the value of p63 immunocytochemical analysis in this distinction.METHODS:Review of cytology records identified 51 consecutive pulmonary specimens (16 fine needle aspiration samples, 15 washes, 12 brushes, and 8 lavages) with the diagnosis of nonsmall cell lung carcinoma (9 carcinomas with squamous differentiation and 42 carcinomas without squamous differentiation). Histologically, they all proved to be nonsmall cell carcinomas, 26 with squamous differentiation and 25 without squamous differentiation. p63 immunocytochemical stain was performed on archival alcohol‐fixed Papanicolaou‐stained cytology slides using standard immunocytochemical methods.RESULTS:Twenty‐three (88 %) of the 26 histologically proven squamous cell carcinomas were positive for p63 on cytologic smears. By using p63 immunocytochemistry, the authors detected 14 carcinomas with squamous differentiation not identified by cytomorphology. Smears from all histologically proven carcinomas with squamous differentiation were positive for p63. Sensitivity of cytology for the detection of nonsmall cell carcinoma of lung with squamous differentiation increased from 35% to 88% using p63 immunocytochemistry (P = .001; McNemar test). The squamous component in 4 carcinomas was detected only in cytologic and not in corresponding histologic samples when subsequent p63 immunostaining was performed.CONCLUSIONS:The authors concluded that p63 is a useful marker for the detection of nonsmall cell carcinomas of lung with squamous differentiation when used in cytologic pulmonary samples. p63 immunocytochemistry significantly increases the sensitivity for the identification of lung neoplasms with squamous differentiation from 35% to 88% (P = .001). Therefore, p63 immunocytochemistry may be used in pulmonary cytologic samples of nonsmall cell carcinomas to identify squamous differentiation and to improve therapeutic selection of patients with lung cancer. Cancer (Cancer Cytopathol) 2009. © 2009 American Cancer Society.
Connexin57 is expressed in dendro‐dendritic and axo‐axonal gap junctions of mouse horizontal cells and its distribution is modulated by light
Authors: Janssen‐Bienhold Ulrike , Trümpler Jennifer , Hilgen Gerrit , Schultz Konrad , De Sevilla Müller Luis Pérez , Sonntag Stephan , Dedek Karin , Dirks Petra , Willecke Klaus , Weiler Reto 
Published: January 2009

AbstractMouse horizontal cells are coupled by gap junctions composed of connexin57. These gap junctions are regulated by ambient light via multiple neuromodulators including dopamine. In order to analyze the distribution and structure of horizontal cell gap junctions in the mouse retina, and examine the effects of light adaptation on gap junction density, we developed antibodies that detect mouse retinal connexin57. Using immunohistochemistry in retinal slices, flat‐mounted retinas, and dissociated retinal cells, we showed that connexin57 is expressed in the dendrites and axon terminal processes of mouse horizontal cells. No staining was found in retinas of connexin57‐deficient mice. Significantly more connexin57‐positive puncta were found in the distal than in the proximal outer plexiform layer, indicating a higher level of expression in axon terminal processes than in the dendrites. We also examined the gap junctions using immunoelectron microscopy and showed that connexin57 does not form hemichannels in the horizontal cell dendritic tips. Light adaptation resulted in a significant increase in the number of connexin57‐immunoreactive plaques in the outer plexiform layer, consistent with previously reported effects of light adaptation on connexin57 expression in the mouse retina. This study shows for the first time the detailed location of connexin57 expression within mouse horizontal cells, and provides the first ultrastructural data on mouse horizontal cell gap junctions. J. Comp. Neurol. 513:363–374, 2009. © 2009 Wiley‐Liss, Inc.
Expression of somatostatin and neuropeptide Y in the embryonic, postnatal, and adult mouse amygdalar complex
Authors: Real María Angeles , Heredia Raúl , del Carmen Labrador María , Dávila José Carlos , Guirado Salvador 
Published: January 2009

AbstractRecent developmental studies indicate that distinct neuronal subpopulations in the amygdala, including somatostatin (SOM)‐containing neurons, originate from progenitor domains in the anterior entopeduncular area, thus suggesting a different origin from subpallial territories for amygdalar versus cortical SOM‐expressing interneurons, the latter derived from the dorsal part of the medial ganglionic eminence. In this context, we carried out an immunohistochemical study analyzing spatiotemporal expression patterns for SOM‐ and neuropeptide Y (NPY)‐containing neurons in the embryonic, postnatal, and adult mouse amygdala. Our results indicate that SOM‐ and NPY‐immunoreactive cells are present in the amygdalar complex from embryonic day (E)12.5, and that these peptidergic cells seem to arise from the anterior entopeduncular area progenitor domain. From E12.5 on there was a notable increase in the number and immunoreactivity of cells containing these peptides in distinct territories of the amygdalar complex, reaching a peak around birth. The distribution pattern for NPY neurons was very similar to that of SOM neurons in most nuclei of the amygdala, although the number of NPY neurons was always lower than that of SOM. At postnatal ages a reduction in the number of immunoreactive cells is observed in most amygdalar nuclei, remaining then similar from P14 to the adult. We interpret this reduction of the number of immunoreactive neurons in relation to the increased immunoreactivity for axons that occurs postnatally. We also suggest that the anterior entopeduncular area‐derived SOM‐ and NPY‐containing neurons in pallial and subpallial amygdaloid nuclei become local interneurons and projection neurons, respectively. J. Comp. Neurol. 513:335–348, 2009. © 2009 Wiley‐Liss, Inc.
Regional differences in olfactory epithelial homeostasis in the adult mouse
Authors: Vedin Viktoria , Molander Marie , Bohm Staffan , Berghard Anna 
Published: January 2009

AbstractThe olfactory sensory neurons in the nasal cavity of the adult mouse are organized into a few regions that differ in their molecular properties, as several classes of genes show regional expression. Most renowned is the fact that expression of each of hundreds of different odorant receptor genes is limited to one such region, or zone, of the olfactory neuroepithelial sheet. Zone differences are in place at birth, as exemplified here by the expression of neuronal progenitor marker Foxg1. We herein describe that an adult pattern showing regional differences in neurogenesis develops during the first few weeks of postnatal life which, e.g., is reflected in the temporal and regional regulation of the neuronal progenitor marker Ascl1. The most dorsomedial zone shows significantly fewer cells in S‐phase in the adult but not in newborn mice by two different measures. Moreover, we show that there are regional differences in the relative differentiation, cell survival, and thickness of the olfactory epithelium. These findings are compatible with the view that zones are inherently distinct and that such differences contribute to generate regional differences in cellular homeostasis that in turn may modulate the capacity of a region to adjust to extrinsic influence. J. Comp. Neurol. 513:375–384, 2009. © 2009 Wiley‐Liss, Inc.
β‐amyloid cortical deposits are accompanied by the loss of serotonergic neurons in the dog
Authors: Bernedo Vanessa , Insua Daniel , Suárez María‐Luisa , Santamarina Germán , Sarasa Manuel , Pesini Pedro 
Published: January 2009

AbstractDogs may naturally suffer an age‐related cognitive impairment that has aroused a great deal of interest, even beyond the field of the veterinary clinic. This canine senile dementia reproduces several key aspects of Alzheimer's disease (AD), including the presence of β‐amyloid (Aβ) deposits in the cerebral cortex, neurodegeneration, and learning and memory impairments. In the present study, we have used unbiased stereological procedures to estimate the number of the dorsal and median raphe nuclei (DRN and MRN, respectively) serotonergic neurons immunolabeled with an anti‐tryptophan hydroxylase (TrH) monoclonal antibody in young and aged dogs without Aβ cortical deposits and in aged dogs with Aβ cortical deposits. The estimated total number of TrH‐labeled neurons (mean ± SD) was 94,790 ± 26,341 for the DRN and 40,404 ± 8,692 for the MRN. The statistical analyses revealed that aged dogs with Aβ cortical pathology had 33% fewer serotonergic neurons in the DRN and MRN than aged dogs without Aβ cortical deposits (108,043 ± 18,800 vs. 162,242 ± 39,942, respectively;P= 0.01). In contrast, no significant variations were found between young and aged dogs without Aβ cortical deposits. These results suggest that degeneration of the serotonergic neurons could be involved in the cognitive damage that accompanies Aβ cortical pathology in the dog and reinforce the use of the canine model for exploring the potential mechanisms linking the cortical Aβ pathology and serotonergic neurodegeneration that occurs during the course of AD. J. Comp. Neurol. 513:417–429, 2009. © 2009 Wiley‐Liss, Inc.