bluuebunny/crossref_metadata_2025_split huggingface dataset:
ZUR FRAGE EINER MASKULINISIERENDEN WIRKUNG VON ALLYLOESTRENOL
Authors: Mey Rudolf 
Published: December 2008

ABSTRACT
Allyloestrenol, an orally efficient gestagen, shows no effect on genital development in female foetuses of rats by intrauterine masculinization test up to doses of 20 mg (5 mg daily for 4 days). Only with increased doses of 40 mg (10 mg daily for 4 days), 60 mg (10 mg for 6 days), and 80 mg (10 mg for 8 days), 9% of the foetuses show persistent Wolffian tubules as manifestation of a slight masculinization. No other signs of masculinization of the genital tract were seen.
The results of animal experiments up to now are critizised: it is demonstrated that by incorrect evaluation of histological slides by some authors allyloestrenol is falsely supposed to have a strong masculinizing effect. The results of human treatment of threatened or habitual abortion correspond with animal experiments: masculinization of new-born following treatment of the mother with allyloestrenol has not yet been observed.
FACTORS AFFECTING THE BINDING OF CORTISOL BY TRANSCORTIN
Authors: De Moor P. , Steeno O. , Deckx R. 
Published: December 2008

ABSTRACT
By means of a gel filtration on Sephadex columns the plasma corticoids can be separated into two fractions: namely a fraction bound to a macromolecular agent and an unbound fraction. When plasma is overloaded with cortisol before gel filtration, the binding capacity of the macromolecular agent can be evaluated. The bound corticoids can be measured quantitatively either fluorimetrically or colorimetrically. The macromolecular binding agent behaves like transcortin in a series of experiments.
Various exogenous and endogenous steroids are known to influence transcortin activity in vivo. Methylestrenolone and lynestrenol administered orally to normal males or to women with various gynaecological conditions did not significantly increase the cortisol binding capacity. Intravenous administration of Metopirone lowered the cortisol binding capacity in normal subjects but not in a patient with hypophysial insufficiency.
Attempts were made to remove steroids from plasma without destroying transcortin, in order to rule out any possible interference with the cortisol binding process by other steroids. Extraction of plasma with organic solvents either at room temperature or at minus 25° C irreversibly destroyed most of the transcortin. Dialysis of plasma against a 1% solution of bovine albumin (40 volumes) for 12 h at 40° C decreased the unconjugated corticoid level by 63%. This procedure did not alter transcortin activity in the plasma of normal adults, in umbilical cord blood, in pregnancy plasma or in the plasma of obese patients with a low cortisol binding capacity. However, the lowering in C.B.C. observed in the plasma of patients treated with Metopirone could be partly abolished by this procedure.
Although the extraction experiments at low temperature suggested the existence of a lipid-link in the cortisol binding system of human plasma, this could not be demonstrated.
HYPOPHYSEAL GONADOTROPHINS FOLLOWING GONADECTOMY IN MALE AND FEMALE ANDROGENIZED RATS
Authors: Johnson Donald C. , Witschi Emil 
Published: December 2008

ABSTRACT
Male and female rats were androgenized by a single injection of testosterone (17β-hydroxy-androst-4-en-3-one) propionate on the 5th postpartum day. At 30 days of age, iittermates were joined in parabiosis and one partner gonadectomized. Gonadotrophin release by the hypophysis of the gonadectomized member was evaluated by effects upon weight and histology of gonads and sex accessories in the intact partner. A total of 80 pairs in 9 combinations were used. Single animals of the same age served as controls.
The results demonstrate that androgenized males have reduced testes and accessory weights at 60 days. However, the treatment does not adversely affect production or release of hypophyseal FSH or LH following castration. In androgenized females, removal of the ovaries results in increased FSH secretion only.
AN EFFECT OF OESTROGEN ON CHONDROITIN SULPHATE OF RAT SKIN CONNECTIVE TISSUE
Authors: Kvarstein Bernt , Nordbö Håkon , Schultz-Haudt Stig D. 
Published: December 2008

ABSTRACT
The effect of oestrogen on polysaccharides of rat skin has been investigated. Skin homogenates were prepared from normal and oestrogen injected male rats. The contents of the homogenates of hexosamines were determined. Furthermore, homogenates were extracted with 0.14 m NaCl in order to obtain polysaccharides. The extracts were applied to paper for electrophoresis either directly, or after digestion with testicular hyaluronidase, in order to isolate and differentiate the various polysaccharides. On the basis of the results obtained, it is suggested that oestrogen has an inhibitory action on the synthesis of chondroitin sulphate Bn of skin connective tissue.
DIE WIRKUNG HOHER OESTROGEN-GABEN AUF DIE AUSSCHEIDUNG VON ALDOSTERON, CORTISOL SOWIE NATRIUM UND KALIUM
Authors: Stark G. , Pfeifer U. 
Published: December 2008

ABSTRACT
Following the administration of large doses of oestrogens for 18 days (2 × 100 mg oestradiol-undecylat, Progynon-Dépot »Schering« in two days) the urinary excretion of aldosterone, cortisol, sodium and potassium was estimated in 15 women.
The excretory values of the hormones and electrolytes did not exceed the normal limit (10 μg aldosterone per day as well as 20 μg cortisol per day) and showed no significant changes as compared with the pre-test period.
It is therefore unlikely that the increased production of oestrogens in pregnancy has an effect upon the excretion of aldosterone, cortisol, sodium and potassium in pregnant women.
EFFECT OF METOPIRONE IN A PATIENT WITH ADRENAL CORTICAL CARCINOMA
Authors: Daniels H. , van Amstel W. J. , Schopman W. , van Dommelen C. 
Published: December 2008

ABSTRACT
The effect of metopirone® (SU-4885)* in a patient with metastatic adrenal cortical carcinoma was studied. The intention was to depress the symptoms of Cushing's syndrome, due to a high glucocorticoid production by the carcinoma. The excretion of 17-KS, 17-KGS, 11-oxo(y)-17-OHCS and 11-desoxy-17-OHCS was followed for seven weeks. The steroid excretion was variable. The 11-oxo(y)-17-OHCS showed a significant decrease during treatment with SU-4885 for seven weeks. The ratio 11-oxo(y)-17-OHCS: 11-desoxy-17-OHCS fell from 1.7 to 0.1 during this period. The excessive glucocorticoid production of the metastatic adrenal carcinoma was suppressed as long as treatment continued. It was not possible to judge the clinical effect of SU-4885 because of the progressive nature of the disease.
INTRAUTERINE ANTIMASKULINE BEEINFLUSSUNG VON RATTENFETEN DURCH EIN STARK GESTAGEN WIRKSAMES STEROID
Authors: Hamada H. , Neumann F. , Junkmann K. 
Published: December 2008

ABSTRACT
The genitalia of male rat foetuses whose mother animals had been treated from the 16th to the 19th day of pregnancy with 6-chloro-/6-1,2α-methylene-17α-hydroxyprogesterone-acetate, a synthetic steroid with high progestational effect, were underdeveloped. The changes are irreversible.
HAEMODYNAMIC CHANGES AND ADRENAL FUNCTION IN MAN DURING INDUCED HYPOGLYCAEMIA
Authors: Arner B. , Hedner P. , Karlefors T. , Westling H. 
Published: December 2008

ABSTRACT
Observations were made on healthy volunteers during insulin induced hypoglycaemia (10 cases) and infusion of adrenaline (3 cases) or cortisol (1 case). In all cases a rise in the cardiac output was registered during insulin hypoglycaemia. The mean arterial blood pressure was relatively unchanged and the calculated peripheral vascular resistance decreased in all cases. A temporary rise in plasma corticosteroids was observed. After infusion of adrenaline similar circulatory changes were observed but no rise in plasma corticosteroids was found. Infusion of cortisol caused an increased plasma corticosteroid level but no circulatory changes. It is concluded that liberation of catechol amines and increased adrenocortical activity following hypoglycaemia are not necessarily interdependent.
EFFECT OF RESERPINE ON PITUITARY PROLACTIN CONTENT AND ITS HYPOTHALAMIC SITE OF ACTION IN THE RABBIT
Authors: Kanematsu S. , Hilliard J. , Sawyer C. H. 
Published: December 2008

ABSTRACT
A single intravenous dose of reserpine (0.5 mg/kg) lowers the level of pituitary prolactin and induces lactation in ovariectomized, oestrogen-primed rabbits. These effects can also be produced by placing a discrete electrolytic lesion in the basal tuberal hypothalamus, and following such a lesion, reserpine exerts no further effects on pituitary prolactin or mammary gland activation. In contrast, when reserpine is administered to rabbits bearing lesions elsewhere in the hypothalamus, depletion of pituitary prolactin and lactation ensues. These results suggest that reserpine-induced prolactin depletion of the pituitary gland, with subsequent lactation, is mediated by a system within the basal tuberal hypothalamus.
A DIRECT ACTION OF PARATHYROID HORMONE ON DEAD BONE IN VITRO
Authors: Gordan Gilbert S. 
Published: December 2008

ABSTRACT
In the presence of human serum albumin, three preparations of parathyroid hormone release radiocalcium from boiled, dried, 45Ca-labelled adult mouse bones. β- or γ-globulin do not replace whole serum or albumin for this effect. The action is not abolished by heating serum to 55° C, indicating that calcium release is not the result of activation of phosphatases or other thermolabile substances. Concentration-action relation is arithmetically linear from 0.07 to 6.7 IU/ml. Under the conditions used, higher concentrations produce no significant further release of radiocalcium. ACTH, α-MSH, β-MSH, ι-thyroxine and cortisol do not release radiocalcium in this system. Sera of patients with hyperparathyroidism have osteolytic activity equal to that of 2.9 ± 0.15 IU of parathyroid peptide per ml. Following surgical cure, and during postoperative hypocalcaemia tetany, the value falls to normal, but not below. Sera of women with disseminated breast cancer have osteolytic activity greater than that of 6.7 IU/ml. It is suggested that this physicochemical action of parathyroid peptide may explain some of its biologic functions as a result of binding of divalent cations by an albumin-parathyroid peptide complex.
ALDOSTERONE AND CORTICOSTERONE SECRETION RATES IN RATS WITH EXPERIMENTAL RENAL HYPERTENSION
Authors: Singer Bertha , Losito Carine , Salmon Sheila 
Published: December 2008

ABSTRACT
In animals with one renal artery clip hypertension was associated with a highly significant increase in aldosterone but not corticosterone secretion rate. In unilaterally nephrcctomized animals with a clip on the remaining renal artery, hypertension was not associated with a significant change in the secretion rates of aldosterone or corticosterone. Experiments designed to determine whether this difference in the groups was due to the fact that in the first group the 'clipped' kidney was still in the circulation during blood collection while in the second it was not have yielded essentially negative results. It is concluded that the increase in aldosterone secretion in renal hypertension is related to the response of the untouched kidney to the clamping of the renal artery of the other kidney.
IN VIVO STUDIES ON THE DEHYDROGENATION OF 3β-HYDROXY-ANDROST-5-EN-17-ONE-3α-3H IN MAN
Authors: Bradlow H. Leon , Fukushima David K. , Zumoff Barnett , Hellman Leon , Gallagher T. F. 
Published: December 2008

ABSTRACT
Studies have been carried out on the metabolism of 3β-hydroxy-androst-5-en-17-one-3α-3H in two subjects. Rapid oxidation of the 3β-hydroxyl group appears to be the primary reaction occurring after the administration of dehydroepiandrosterone-3H with a substantial portion of the 3H appearing in the body water pool. Reduction to epiandrosterone does not occur to any significant extent before oxidation of the hydroxyl group. A small amount of 3H was found in androsterone and epiandrosterone indicating that some of the liberated 3H may be incorporated during the reduction of the double bond.
INCREASE OF β-GLUCURONIDASE ACTIVITY ON INCUBATION OF NORMAL AND TESTOSTERONE-STIMULATED MICE KIDNEY PREPARATIONS
Authors: Varma T. N. R. , Brodie Harry J. , Kwass George , Hayano Mika , Dorfman Ralph I. 
Published: December 2008

ABSTRACT
Preliminary investigations establishing a standard assay procedure for β-glucuronidase in mice kidneys were carried out. Using this procedure, the effect of incubation of several mice kidney preparations on the enzyme activity was measured. Kidney slices from untreated mice showed an average increase of about 25 % of the enzyme activity during incubations for 4.5 hours (P < 0.0125). Under identical conditions, the kidney slices of testosterone-treated mice increased in activity by about 9 % (P < 0.0125). No increase of activity was observed with kidney half-sections or homogenates, with kidney slices incubated anaerobically and with kidney slices of sesame oil-treated and sham-injected mice. Studies on the rate of increase of activity with time with kidney slices of untreated mice showed an increase of about 7 % in 0.75 hour, 13 % in 1.5 hours, 25% in 4.5 hours and 33 % in 7.5 hours, whereas with testosterone-treated mice kidney slices, the increase was about 8 % in 0.75 hour and 9.5 % in 1.5 hours with a slight decrease up to 7.5 hours.
ALTERATIONS OF THYROXINE-BINDING PROTEIN IN CLINICALLY HYPO- AND HYPERTHYROID PATIENTS WITH NORMAL PBI LEVEL
Authors: Lemarchand-Béraud Th. , Assayah M.-R. , Vannotti A. 
Published: December 2008

ABSTRACT
Six patients, clinically hypothyroid in spite of a normal or elevated protein-bound iodine (PBI) level, and six hyperthyroid patients with a low level of PBI are described. In these patients, a probable modification of the transport of the thyroid hormones is revealed by means of in vitro uptake of T3 by erythrocytes (Hamolsky's test) and by the determination of the binding capacity of the thyroxine-binding protein (TBP or TBG). In the first group, the labelled triiodothyronine uptake by the erythrocytes is low and the TBP-binding capacity is higher than normal. In the second group, the elevated percentage of free hormones and the low TBP-binding capacity may partly explain the hyperthyroidism despite the low PBI level. PBI concentration in the thyrotoxic range with high TBP binding capacity, is also demonstrated in infectious hepatitis. The meaning of these results is discussed.
A FLUORESCENT REACTION FOR MONOAMINES IN THE INSULIN PRODUCING CELLS OF THE GUINEA-PIG
Authors: Falck Bengt , Hellman Bo 
Published: December 2008

ABSTRACT
Certain catecholamines and tryptamines condense in freeze-dried tissues with formaldehyde to form intensely fluorescent products. A distinct fluorescence has recently been demonstrated in the islets of Langerhans from several species with this sensitive and specific technique. The fluorescent reaction of the islets has been studied in more detail in the guineapig. Using a combination of fluorescence microscopy with subsequent silver impregnation and granule staining on the same section it was found that the fluorescent cells were identical with the B cells. The B cells exhibited no, or only weak, fluorescence after administration of reserpine. The colour of the emitted fluorescent light suggests that the B cells contain a tryptamine rather than a catecholamine. Since the fluorescent material was distributed in fine cytoplasmic granules the amine may be associated with the aldehyde-fuchsin positive granules which are regarded as the storage site for insulin or some insulin precursor. No support was found for the previous concept of an adrenergic parenchymatous innervation of the islets of Langerhans.
CORRELATION BETWEEN ANTIDIURETIC HORMONE EFFECT AND THE RENAL EXCRETION OF MAGNESIUM AND CALCIUM IN MAN
Authors: Nielsen Bent 
Published: December 2008

ABSTRACT
The effect of injection of physiological doses of commercial preparations of lysine- or arginine-vasopressin on the renal excretion of magnesium and calcium was studied in 20 hydrated normal subjects.
In the majority of the experiments the injections were followed by a rise in the rate of excretion of magnesium as well as of calcium.
In 3 subjects endogenously induced antidiuresis produced similar effects.
In 1 case no changes were revealed during antidiuresis.
The most probable explanation of these results would seem to be that the antidiuretic hormone exerts an inhibitory effect on the renal tubular reabsorption of magnesium and calcium.
THE MAXIMUM TUBULAR REABSORPTION OF PHOSPHATE IN ACROMEGALY
Authors: Cattaneo C. , Martini P. F. , Modica A. 
Published: December 2008

ABSTRACT
The glomerular filtration rate and the maximum tubular reabsorption of phosphate were determined in 5 patients with acromegaly. In 4 cases these functions were increased proportionally. In the fifth case they were normal.
The findings are discussed in relation to present knowledge of the nephrotropic action of growth hormone.
PLASMA ANDROGENS IN WOMEN
Authors: Dignam W. J. , Pion R. J. , Lamb E. J. , Simmer H. H. 
Published: December 2008

ABSTRACT
Plasma levels of conjugated DHEA, conjugated androsterone (modified method of Migeon & Plager) and testosterone (method of Finkelstein et al.) were determined in a group of 20 patients with polycystic ovaries and hirsutism or virilism, before and after intravenous HCG stimulation and ACTH-suppression with dexamethasone.
Mean values for testosterone, conjugated DHEA and androsterone were.34 ±.24 μg/100 ml, 50.9 ± 28.3 μg/100 ml and 31.4 ± 19.4 μg/100 ml respectively, all significantly higher than levels found in normal women. In all, but 3 cases, testosterone values were above the 2-sigma range of normal women in contrast to the frequent overlapping observed for conjugated DHEA and androsterone. HCG stimulation led to a significant rise in the mean value of testosterone (.61 ±.22 μg/100 ml) but little change was seen in those of the conjugates. While dexamethasone caused a marked decrease of testosterone in only 2 patients, it led to a pronounced fall in DHEA values and a lesser but significant drop in androsterone concentrations in most patients. In patients with a unilateral polycystic or with bilateral polycystic ovaries but without hirsutism or virilism similar values were noted. Two patients with arrhenoblastomas, 4 patients with adrenal disorders and 13 patients with hirsutism of unknown origin were studied and their findings presented. All patients with hirsutism or virilism had a higher mean value of testosterone than did normal women. The testosterone levels did not parallel the severity, although a correlation did seem to exist in the mildly and moderately hirsute patients. Plasma androgen determinations in general and plasma testosterone studies, in particular, while helpful in elucidating the clinical manifestations of masculinization do not allow the investigator to differentiate an adrenal from an ovarian source. Adjunctive studies, utilizing HCG and dexamethasone, are helpful, but not conclusive.
FAILURE TO INDUCE DECIDUAL CELL REACTION IN LACTOGENIC HORMONE TREATED AND PSEUDOPREGNANT RATS
Authors: Herlyn U. , Geller H. F. , von Berswordt-Wallrabe Ilse 
Published: December 2008

ABSTRACT
The decidual cell reaction (DCR) was studied in intact rats under influence of exogenous and/or endogenous (by induction of pseudopregnancy) lactogenic hormone (LGH).
No or a very small DCR occurred in rats traumatized on day 6 of the experiment after 5 days of LGH treatment, starting at the time of late vaginal oestrus, or after 5 days of pseudopregnancy, induced by glass rod stimulation during vaginal oestrus. All the rats, killed on day 10, had ovaries with active corpora lutea.
The absence of DCR after trauma on day 6 is due to a temporal factor, which prevents the endometrium reacting even in presence of active corpora lutea.
ISOLIERUNG OESTROGENER STEROIDE AUS KÖRPERFLÜSSIGKEITEN LANDWIRTSCHAFTLICHER NUTZTIERE DURCH MIKROSUBLIMATION
Authors: Rommel P. 
Published: December 2008

ABSTRACT
From the chromogenic compounds, being highly concentrated after separation, we got (by repeated column-chromatographic rectification with Al2O3 and fractionation of the resulting extracts, as well as by reiterate transsublimation of the crystalline residues) crystals, the shapes of which were typical of the different oestrogenic fractions (oestrone, 17α-oestradiol and 17β-oestradiol). They were identified by microscopical determination of their melting points.
We succeeded in isolating
oestrone and 17β-oestradiol from the urine of pregnant mares, oestrone from the urine of highly pregnant cows and pregnant sows, oestrone and 17α-oestradiol from the amniotic liquor of the cow, oestrone from the amniotic liquor of swine, and oestrone from the urine and the bile of pig-foetuses.
EFFECTS OF CERTAIN HORMONES ON THE METABOLISM OF BULL SPERMATOZOA
Authors: Mounib M. Said 
Published: December 2008

ABSTRACT
17β-Oestradiol, progesterone, testosterone, PMS and HCG were tested for their possible effects on the metabolism of washed bull spermatozoa when incubated in Krebs-Ringer phosphate medium at 37° C.
Steroid hormones suppressed the oxygen uptake of the spermatozoa, and this was particularly evident with progesterone and testosterone the addition of which led also to a rise in substrate (glucose and pyruvate) utilization and in lactate production. Steroid hormones (1 mg/4 ml suspension) produced their effects when they were added to the medium as crystals or after they had been dissolved in propylene glycol, but more effectively in the latter case. The anaerobic glycolysis of spermatozoa, however, was not influenced by steroid hormones.
PMS and HCG at the doses used (20 IU/4 ml suspension) did not affect the metabolism of spermatozoa.
The results are discussed in relation to the possibility that steroid hormones may play a direct part in regulating the metabolic pattern of spermatozoa, which may be, in turn, associated with a shift from the epididymal to the ejaculated and then to the capacitated pattern.
17-HYDROXYCORTICOIDS IN MOUSE ADRENAL INCUBATES
Authors: Varon H. H. , Touchstone J. C. 
Published: December 2008

ABSTRACT
Cortisol and a steroid identified tentatively as a 17-hydroxycorticoid are abundant components in adrenal incubates of young male mice but are suppressed after sexual maturation. These data suggest that the mouse adrenal can elaborate large quantities of 17-hydroxycorticoids and that production of these compounds may be inhibited by androgens.
HYPOPHYSEO-ADRENAL FUNCTION IN DIABETIC ANGIOPATHY
Authors: Szücs S. , Csapó G. 
Published: December 2008

ABSTRACT
It has been demonstrated that alterations in the corticotrophin-glucocorticoid system follow the extreme changes in carbohydrate metabolism which occur in diabetic patients. In acidosis and hypoglycaemia there is a transitory pathological increase in the plasma cortisol level and in the urinary 17-OHCS excretion. If the diabetes is satisfactorily controlled – even in labile patients – the average values are normal. In satisfactorily controlled angiopathic patients a pathologically increased hormone production cannot be demonstrated. In the uraemic phase of the Kimmelstiel-Wilson syndrome the function of the adrenal cortex deteriorates.