bluuebunny/crossref_metadata_2025_split huggingface dataset:
Carbonic anhydrase IX: A new druggable target for the design of antitumor agents
Authors: Winum Jean‐Yves , Rami Marouan , Scozzafava Andrea , Montero Jean‐Louis , Supuran Claudiu 
Published: September 2007

AbstractCarbonic anhydrases (CAs, EC 4.2.1.1) are a family of enzymes widespread in all life kingdoms. In mammals, isozyme CA IX is highly overexpressed in many cancer types being present in few normal tissues. Its expression is strongly induced by hypoxia present in many tumors, being regulated by the HIF transcription factor and correlated with a poor response to classical chemo‐ and radiotherapies. CA IX was recently shown to contribute to acidification of the tumor environment, by efficiently catalyzing the hydration of carbon dioxide to bicarbonate and protons with its extracellularly situated active site, leading both to the acquisition of metastasic phenotypes and to chemoresistance with weakly basic anticancer drugs. Inhibition of this enzymatic activity by specific and potent inhibitors was shown to revert these acidification processes, establishing a clear‐cut role of CA IX in tumorigenesis. The development of a wide range of potent and selective CA IX inhibitors belonging to diverse chemical classes, such as membrane‐impermeant, fluorescent or metal‐containing such agents, could thus provide useful tools for highlighting the exact role of CA IX in hypoxic cancers, to control the pH (im)balance of tumor cells, and to develop novel diagnostic or therapeutic applications for the management of tumors. Indeed, both fluorescent inhibitors or positively charged, membrane impermeant sulfonamides have been recently developed as potent CA IX inhibitors and used as proof‐of‐concept tools for demonstrating that CA IX constitutes a novel and interesting target for the anticancer drug development. © 2007 Wiley Periodicals, Inc. Med Res Rev, 28, No. 3, 445–463, 2008
Symmetry group classification of ordinary differential equations: Survey of some results
Authors: Mahomed F. M. 
Published: September 2007

AbstractAfter the initial seminal works of Sophus Lie on ordinary differential equations, several important results on point symmetry group analysis of ordinary differential equations have been obtained. In this review, we present the salient features of point symmetry group classification of scalar ordinary differential equations: linear nth‐order, second‐order equations as well as related results. The main focus here is the contributions of Peter Leach, in this area, in whose honour this paper is written on the occasion of his 65th birthday celebrations. Copyright © 2007 John Wiley & Sons, Ltd.
The influence of olive oil on human health: not a question of fat alone
Authors: Pérez‐Jiménez Francisco , Ruano Juan , Perez‐Martinez Pablo , Lopez‐Segura Fernando , Lopez‐Miranda Jose 
Published: September 2007

AbstractOlive oil is the most representative food in the traditional Mediterranean diet and its most important source of MUFA. The healthy benefits of MUFA‐rich diets on plasma cholesterol levels, were the first to generate interest in this dietary model. In addition to the benefits conferred by its lipids, olive oil has other biological effects, some of them also related to MUFA. However, most recent studies have shown that there are a number of properties that depend on, or are potentiated by, the consumption of olive oil, such as virgin olive oil, that is rich in microcomponents. This foodstuff, thanks to its double set of benefits, thus tends to produce a better lipid profile and a less prothrombotic environment, promoting antioxidant and anti‐inflammatory effects, with a greater endothelial protective capacity. In view of these effects, it would appear that when olive oil is the basic source of dietary alimentary fat it has a major antiatherogenic capacity, which is not shared to the same extent by other oils that are rich in oleic acid but lack its characteristic micronutrients.
Mediterranean diet and the metabolic syndrome
Authors: Esposito Katherine , Ciotola Miryam , Giugliano Dario 
Published: September 2007

AbstractThe metabolic syndrome (also referred to as syndrome X or the insulin resistance syndrome) has emerged as an important cluster of risk factors for atherosclerotic disease. Patients with the syndrome also are at increased risk for developing type 2 diabetes mellitus. Common features are central (abdominal) obesity, insulin resistance, hypertension, and dyslipidemia. Weight reduction deserves first priority in individuals with abdominal obesity and the metabolic syndrome. Both weight reduction and maintenance of a lower weight are best achieved by a combination of reduced caloric intake and increased physical activity. Dietary patterns close to the Mediterranean diet and rich in fruit and vegetables, and high in monounsaturated fats are negatively associated with features of the metabolic syndrome. Some recent studies dealing specifically with the effect of interventions on the resolution of the metabolic syndrome have demonstrated a 25% net reduction in the prevalence of the syndrome following lifestyle changes mainly based on nutritional recommendations. Similar rates of resolution have been obtained with drugs, such as rosiglitazone and rimonabant. The favourable benefit/hazard ratio makes Mediterranean‐style diets particularly promising to reduce the cardiovascular burden associated with the metabolic syndrome.
Olive oil and the haemostatic system
Authors: Lopez‐Miranda Jose , Delgado‐Lista Javier , Perez‐Martinez Pablo , Jimenez‐Gómez Yolanda , Fuentes Francisco , Ruano Juan , Marin Carmen 
Published: September 2007

AbstractInterest in the Mediterranean diet (MD) has grown worldwide due to its link with greater longevity and lower cardiovascular disease rate, cancer and age cognitive decline. Despite the high complexity of its nutrients composition, olive oil emerges as its principal food, since it provides the higher percent of energy and a lot of bioactive compounds. In this review we will discuss the benefits of diets enriched in virgin olive oil, whose effects are probably due not only to its oleic acid content but also to its other potentially health‐promoting components. Traditionally, the benefits of MD were linked to its effect on lipoprotein metabolism but today we realise that there exists a whole sheaf of other benefits, including the components of haemostasis: platelet function, thrombogenesis and fibrinolysis. A diet enriched in virgin olive oil can reduce the sensitivity of platelets to aggregation, decreasing von Willebrand and tromboxane B2plasma levels. Moreover a particular interest has arisen about its capacity to decrease fasting Factor VII plasma levels and to avoid or modulate its postprandial activation. Also Tissue Factor expression in mononuclear cells could be reduced with the chronic intake of virgin olive oil and finally, studies performed in different experimental situation have shown that it could also increase fibrinolytic activity, reducing plasma concentration of Plasma Activator Inhibitor type‐1.
Intervention studies on Mediterranean diet and cardiovascular risk
Authors: Lairon Denis 
Published: September 2007

AbstractThe traditional Mediterranean diet, as studied in the 1950s to 1960s in the South of Europe, is characterized by moderate energy intake, low animal fat, high olive oil, high cereals, high legumes, nuts and vegetables, and regular and moderate wine. A Mediterranean‐type diet is being developed to mimic the traditional one and fit with present life style. While numerous epidemiological studies have supported the concept that adherence to the traditional Mediterranean diet is beneficial for health and particularly protects against cardiovascular disease, the limited number of intervention studies in this field have not yet provided major support. Nevertheless, the dietary interventions performed until now have demonstrated that adoption of a Mediterranean‐type diet reduces several cardiovascular risk factors in subjects at risk (primary prevention) and/or cardiovascular events or mortality in patients after a first cardiac event (secondary prevention). Among numerous foodstuffs characterizing the Mediterranean diet, virgin olive oil has been shown to display beneficial effects on a wide range of risk factors.
Olive oil and longevity
Authors: Trichopoulou Antonia , Dilis Vardis 
Published: September 2007

AbstractSeveral lines of evidence point to olive oil and the olive oil‐centered Mediterranean diet as conducive to longevity. The evidence stems from ecological, as well as analytic epidemiological studies assessing olive oil, monounsaturated lipids or the Mediterranean dietary pattern in relation to the incidence of, or mortality from, major common diseases, or overall mortality. Mechanistic considerations are addressed by biochemical studies, whereas randomized clinical trials provide further support to the evidence generated from observational investigations. The content of olive oil in several microcomponents with antioxidant potential, as well as its high content in monounsaturated lipids appear to be essential for the beneficial effect of this food.
Molecular mechanisms of the effects of olive oil and other dietary lipids on cancer
Authors: Escrich Eduard , Moral Raquel , Grau Laura , Costa Irmgard , Solanas Montserrat 
Published: September 2007

AbstractCancer is one of the main causes of mortality worldwide. Geographical differences in incidence rates suggest a key effect of environmental factors, especially diet, in its aetiology. Epidemiologic and experimental studies have found a role of dietary lipids in cancer, particularly breast, colorectal, and prostate cancers. Their incidence in the Mediterranean countries, where the main source of fat is olive oil, is lower than in other areas of the world. Human studies about the effects of dietary lipids are little conclusive, probably due to methodological issues. On the other hand, experimental data have clearly demonstrated that the influence of dietary fats on cancer depends on the quantity and the type of lipids. Whereas a high intake of n‐6 PUFA and saturated fat has tumor‐enhancing effects, n‐3 PUFA, conjugated linoleic acid and γ‐linolenic acid have inhibitory effects. Data regarding MUFA have not always been conclusive, but high olive oil diets seem to have protective effects. Such effects can be due to oleic acid, the main MUFA in olive oil, and to certain minor compounds such as squalene and phenolic compounds. This work aims to review the current knowledge about the relationship between dietary lipids and cancer, with a special emphasis on olive oil, and the molecular mechanisms underlying these effects: modifications on the carcinogenesis stages, hormonal status, cell membrane structure and function, signal transduction pathways, gene expression, and immune system.
Erratum: Dual and triple‐band PIFA design for WLAN applications
Authors: Sim Chow‐Yen‐Desmond 
Published: September 2007

AbstractOriginally published Microwave Opt Technol Lett 49: 2159–2162, 2007. © 2007 Wiley Periodicals, Inc. Microwave Opt Technol Lett 49: 3192, 2007; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.22885
Effect of a finite ground plane on Peano fractal loaded monopole antenna
Authors: Yan‐min Yu , Yi‐ming Tang , Wen Wu 
Published: September 2007

AbstractThe effect of a finite ground plane on Peano monopole antenna is investigated. Simulated and measured data indicate that when the size of ground plane decreases, impedance bandwidth and gain of the antenna will decrease, H‐plane pattern will change little, 3‐dB beam width will become wider and elevation angle will be smaller in E‐plane. © 2007 Wiley Periodicals, Inc. Microwave Opt Technol Lett 49: 3087–3090, 2007; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.22891
A compact ultra‐wideband slot antenna with multiple notch frequency bands
Authors: Ding Jiechen , Lin Zhili , Ying Zhinong , He Sailing 
Published: September 2007

AbstractA compact printed ultra‐wideband slot antenna with superior multiple band‐notched characteristics is presented. The size of the UWB slot antenna is minimized, and multiple split ring resonators are printed inside the inner patch to achieve multiple notch frequency bands. As a practical example, a UWB antenna (working from 2.4 to 10.1 GHz) etched with two sets of split ring resonators are fabricated and its VSWR and radiation patterns are measured. The measured results agree well with the simulation, and the two notch frequency bands are centered at 3.65 and 5.75 GHz. © 2007 Wiley Periodicals, Inc. Microwave Opt Technol Lett 49: 3056–3060, 2007; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.22892
An extremely compact dual‐band branch‐line coupler
Authors: Yuan Shih‐Yi , Shiau Miin‐Shyue , Liao Shry‐Sann , Sun Pou‐Tou , Ho Chia‐Tai 
Published: September 2007

AbstractIn this article, an extremely compact dual‐band branch‐line coupler is presented. The miniaturized design saved 74% circuit dimension comparing to the original dual‐band branch‐line coupler. Several design methods and miniaturization techniques were involved in this study to achieve the criteria, including stepped‐impedance resonators (SIR) structure, symmetrical T‐shape structure, bended and folded of transmission lines, and the coupling effect of microstrip‐lines. Good agreements between the simulated and measured results were also observed. Furthermore, no lumped elements, via‐holes, and bonding wires are necessary for this miniaturized coupler, making it very useful for the modern wireless communication systems. © 2007 Wiley Periodicals, Inc. Microwave Opt Technol Lett 49: 3011–3014, 2007; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.22895
Harmonics suppression microstrip diplexer for 3G wireless communication system using fractal‐shaped geometry
Authors: Liang Jian‐Gang , Chen Wen‐Ling , Wang Guang‐Ming 
Published: September 2007

AbstractMicrostrip diplexer using Koch fractal shape is proposed for the first time. By constructing the microstrip coupled‐lines in Koch fractal shapes, the second harmonic of the fractal microstrip diplexer can be significantly suppressed and, higher the iteration order of the fractals, the more apparent this effect becomes. In this paper, a fractal‐shaped microstrip diplexer for 3G wireless communication system is designed, fabricated, and measured; the measurement results verified the proposed method. © 2007 Wiley Periodicals, Inc. Microwave Opt Technol Lett 49: 2973–2975, 2007; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.22897
Stimulated Brillouin scattering and Rayleigh cooperative process in 300 km optical transmission
Authors: Zhang Dechao , Zhang Xiaoru , Li Xiaolin , Xu Anshi , Wang Ziyu , Zhang Fan , Chen Zhangyuan 
Published: September 2007

AbstractThe generation of high‐order Brillouin Stokes is experimentally demonstrated in 300 km all‐Raman transmission with normal Raman pumps and without mirror reflection, and a longest ever fiber laser is implemented at the same time. The OSNRs of the two Brillouin Stokes after 300 km are both higher than 29 dB. © 2007 Wiley Periodicals, Inc. Microwave Opt Technol Lett 49: 2939–2941, 2007; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.22899
Millimetre wave signal generation using resonant tunneling diodes NLTL‐resonators
Authors: Jaeger Irina , Kalinowski D. , Stöhr A. , Stiens Johan , Vounckx Roger , Jäger Dieter 
Published: September 2007

AbstractWe present a novel approach of millimetre wave power generation using active microstructured nonlinear transmission line (NLTL) oscillators consisting of a periodic array of resonant tunneling diodes (RTDs). RTD‐NLTLs resonators have been measured to operate as distributed oscillators up to 50 GHz with power output up to −10 dBm. © 2007 Wiley Periodicals, Inc. Microwave Opt Technol Lett 49: 2907–2909, 2007; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.22902
Fast all modes (FAM) method combined with NMSP for evaluating spatial domain layered medium Green's functions of moderate thickness
Authors: Wu Boping , Tsang Leung , Ong Chong‐Jin 
Published: September 2007

AbstractAn efficient and novel approach, the fast all modes (FAM) method, was developed to locate all modes precisely on the entire complex plane for a single layered media. The modes include surface wave modes, leaky wave modes, and improper modes. For the case where the layer thickness is 1 wavelength, the pre‐processing FAM requires 0.34 s for computing 500 mode locations of both TE and TM modes using a Pentium IV 3.2 GHz PC running Matlab. To justify our FAM method, we use the numerical modified steepest‐descent path (NMSP) method to evaluate spatial domain Green's functions for mixed potentials GA and GV. The NMSP method computes the steepest descent integral with all the pole proximities extracted and replaced by incomplete error functions. The CPU per distance point based on the FAM/NMSP method takes less than 6 mss for all distance ranges. All computed results are accurate to within 0.2% of the conventional half space extraction method. © 2007 Wiley Periodicals, Inc. Microwave Opt Technol Lett 49: 3112–3118, 2007; Published online in Wiley Inter‐Science (www.interscience.wiley.com). DOI 10.1002/mop.22907
Transmission characteristics of multiple ellipticle ridge wavequide
Authors: Li Guojian , Xu Fuyong , Ma Aning 
Published: September 2007

AbstractA new kind of multiple elliptical ridge waveguide is presented. The design data for the air‐filled and dielectric‐loaded double, quadruple, and sextuple elliptical ridge waveguide are presented by finite element method for the first time. Variations of the cut‐off wavelength, single‐mode bandwidth with the ridge dimensions for different values of dielectric constant are investigated in detail. The correctness of the numerical results is verified. The results provide an extension to the existing design data for ridge waveguide and considered helpful in practical applications. © 2007 Wiley Periodicals, Inc. Microwave Opt Technol Lett 49: 3082–3085, 2007; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.22909
Second‐order accurate FDTD equations at dielectric interfaces
Authors: Chu Qing‐Xin , Ding Hai 
Published: September 2007

AbstractThe rigorous second‐order accurate finite‐difference time‐domain method equations at dielectric interfaces are straightforwardly derived though the discretization of the integral forms of Maxwell's curl equations on the nonuniform Yee's lattice and Taylor series extending of continuous field components over finite volumes including the interfaces. It is shown that to obtain second‐order accuracy, we not only require to construct proper effective permittivities in the grids containing the dielectric interfaces, but also to choose nonuniform Yee's grids available in the vicinity of the interface. The attempts in the past are not appropriate for this purpose based on the uniform Yee's lattice. © 2007 Wiley Periodicals, Inc. Microwave Opt Technol Lett 49: 3007–3011, 2007; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.22912
Dual butler matrix active antenna system
Authors: Rahim Sharul Kamal Abdul , Gardner Peter 
Published: September 2007

AbstractThis article describes a smart antenna system that employs low noise amplifiers and two cascaded Butler Matrices. The output signals from the first Butler Matrix, which acts as a beamforming network, have high gain and narrowbeam width for long distance communication while the outputs from the second Butler Matrix, which acts as a mirror of the first Butler Matrix, reconstructing the antenna patterns of the individual radiating elements, have high linearity and broad beam width that can be used for short distance communication. Switching or selecting between the two sets of beams allows reception to be optimized for either vehicle to vehicle or vehicle to roadside beacon communications. © 2007 Wiley Periodicals, Inc. Microwave Opt Technol Lett 49: 3004–3007, 2007; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.22913
SNR measurement in a beamforming network
Authors: Rahim Sharul Kamal Abdul , Gardner Peter 
Published: September 2007

AbstractArray antennas with integrated low noise amplifiers have been combined with a butler matrix (BM) to form a beamforming network that can improve the performance of wireless communication systems. The performance of a four‐element array with and without the low noise amplifiers and with and without the BM have been evaluated, in terms of the measured signal to noise ratio (SNR) at each output port. These SNR output signals are then combined to calculate and compare the diversity gains available with selection combining and maximal ratio combining. The results show that selecting the strongest output from the BM gives SNR performance comparable with that of maximal ratio combining, when LNAs are used to compensate for the BM loss. © 2007 Wiley Periodicals, Inc. Microwave Opt Technol Lett 49: 2968–2973, 2007; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.22914
Calculation of optimized parameters of rectangular microstrip patch antenna using particle swarm optimization
Authors: Yilmaz A. Egemen , Kuzuoglu Mustafa 
Published: September 2007

AbstractIn this letter, the particle swarm optimization has been applied to calculate the optimized length and width of rectangular microstrip antennas. The inputs to the problem are the dielectric constant and thickness of the substrate; together with the desired resonant frequency; the outputs are the optimized length and width; where the antennas are considered to be electrically thin. The results are in good agreement with the results (experimental and calculated by other heuristics) in the literature. © 2007 Wiley Periodicals, Inc. Microwave Opt Technol Lett 49: 2905–2907, 2007; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.22918
Characterization of on‐chip miniature multilayer spiral inductors for RFICS
Authors: Xie Jian‐Yong , Yin Wen‐Yan , Shi Jinglin , Kang Kai , Chen Zhizhang David 
Published: September 2007

AbstractSeveral existing closed‐form equations for calculating DC inductance and resistance of single‐spiral inductors are examined at first, and the most accurate formula is chosen for characterizing the DC inductance of multilayer spiral inductors. The partial element equivalent circuit (PEEC) method is implemented for computing their frequency‐dependent (AC) resistance and inductance. To validate our calculated results, we designed and fabricated some multilayer spiral inductors using standard 0.18 μm CMOS technology. The on‐chip measurements are carried out so as to obtain two‐port S‐parameters of these inductors. Excellent agreements are obtained between the calculated and experimental results, which include DC and low‐frequency inductances of three‐, four‐, and fiver‐layer spiral inductors, respectively. © 2007 Wiley Periodicals, Inc. Microwave Opt Technol Lett 49: 3180–3184, 2007; Published online in Wiley InterScience (www.interscience.wiley.com).DOI 10.1002/mop.22920