bluuebunny/crossref_metadata_2025_split huggingface dataset:
Melanoma of the external ear
Authors: Cole David J. , Mackay Gregory J. , Walker Bruce F. , Wooden William A. , Murray Douglas R. , Coleman John J. 
Published: February 2007

AbstractManagement of melanoma of the external ear is controversial. Thirty‐one patients treated for this disease were identified at our institution between January 1, 1974 and December 31, 1989. Follow‐up was an average of 7.12 years (range 1–15). Local therapy performed included 16 wedge resections, 3 split thickness skin grafts after excision to the perichondrium, 10 partial and 2 total amputations. There were two local recurrences, four metachronous cervical metastases, and four distant metastases. Three elective and five therapeutic neck dissections were performed. Survivors at 1, 5, and 10 years were 93, 77, and 47%, respectively. There was no relationship between DNA ploidy, local surgical therapy, and eventual recurrence. Clinical stage and tumor thickness demonstrated a statistically significant correlation with likelihood of recurrence (P = .02 and .05). There is no evidence that melanoma of the ear has a poorer prognosis or different prognostic factors than melanoma at other cutaneous sites. In selected cases, local disease can be controlled by excision and skin graft rather than the more aggressive current procedures. © 1992 Wiley‐Liss, Inc.
Prognostic significance of dna measurement determined by image analysis in human breast carcinoma
Authors: Mir Rabia , Johnson Houston , Margolis Melissa , Teplitz Steven , Wise Leslie 
Published: February 2007

AbstractThe nuclear DNA of human breast carcinoma cells was studied by image analysis using archival paraffin‐blocked tissues from two groups of patients with breast cancers. One group had survived > 10 years (N = 20) and the other <3 years (N = 26) after the initial diagnosis. Cellular preparations were made from pepsin‐digested deparaffinated sections. The nuclear DNA was stained with Feulgen stain and measured by a computerized image analysis system. The data show that in addition to nodal status the pattern of DNA histograms obtained from image analysis can provide powerful prognostic information in breast carcinoma. The prognostic value of DNA histogram patterns may be independent of nodal status. © 1992 Wiley‐Liss, Inc.
Cancer of the esophagus in young adults
Authors: Patil Prakash K. , Patel Snehal G. , Mistry Rajesh C. , Deshpande Raman K. , Desai Prafulla B. 
Published: February 2007

AbstractClinicopathological features and survival data of squamous cell carcinoma of the esophagus were analyzed from the viewpoint of age differences in 453 patients treated at the Tata Memorial Hospital, Bombay, India. Two groups were studied: group A, aged 35 years or less; and group B, aged above 35 years. There was no significant difference among the two groups with regard to sex distribution, site and length of the tumor, operability, morphology, histological grade, vascular and lymphatic invasion, and lymph node metastasis. The primary lesion was more advanced and the rate of incomplete resections was higher in younger patients. The incidence of cardiopulmonary complications and postoperative deaths was significantly lower in younger patients. Recurrence of the disease following complete resection was more frequent in the younger age group (chi2 = 2.61; P = .1063), although the pattern of recurrence remained the same in both groups. Disease‐free survival in younger patients following complete resection of the tumor was poorer as compared to the older patients, but the difference is statistically not significant (chi2 = 1.882; P = .1701). These findings suggest either a delayed diagnosis or a biologically sinister disease in the younger group; further studies of the two groups vis‐a‐vis their biologic parameters (DNA ploidy, etc.) are in progress and will form the subject of another communication. © 1992 Wiley‐Liss, Inc.
Serum squamous cell carcinoma antigen levels in invasive squamous vulvar cancer
Authors: Rose Peter G. , Nelson Beth E. , Fournier Lawrence , Hunter Richard E. 
Published: February 2007

AbstractSquamous cell carcinoma (SCC) antigen levels were studied in 34 patients with primary (N = 27) or recurrent (N = 7) SCC of the vulva. In primary disease, the SCC antigen level was greater than 2.5 ng/ml in only four patients (15%). Elevated antigen levels ranged from 2.7–18.0 ng/ml. All of these patients had advanced disease by either clinical or surgical staging systems. Four of twelve patients with inguinal metastasis had elevated SCC antigen levels. In two of these patients the inguinal nodes were abnormal to palpation. No association of the SCC level and the degree of tumor differentiation was observed. SCC antigen levels were increased slightly (2.7–4.5 ng/ml) in three of six patients with locally recurrent disease. In one patient with distant recurrence the SCC antigen was 15.3 ng/ml. In both primary and recurrent disease all elevated SCC antigen levels decreased with effective therapy. Vulvar cancer is primarily a local disease that is easily assessed by physical examination. An effective tumor marker in vulvar cancer would benefit only the rare patient with distant but not local disease. © 1992 Wiley‐Liss, Inc.
Schedule dependent inhibition of thymidylate synthase and tumor growth by 5‐fluorouracil in yoshida sarcoma bearing rats
Authors: Tsujinaka Md Toshimasa , Kido Yoshihiro , Shiozaki Hitoshi , Mori Takesada , Karakousis Constantine P. 
Published: February 2007

AbstractSchedule dependent inhibition of thymidylate synthase (TS) and tumor growth by 5‐fluorouracil (FUra) was examined in Yoshida sarcoma (YS) bearing Donryu rats. After implantation of YS cells (1 × 104), FUra (20 mg/kg/day) was continuously (group C) or daily bolus injection (group B) administered for 6 days. On day 7, tumor weight was 1.57 ± 0.58 g in group C and 0.45 ± 0.10 g in group B (P < 0.01), free TS was 2.23 ± 83 fmol/mg protein in group B and 96 ± 55 fmol/mg protein in group C (P < 0.05), and inhibition rate of TS was 88.3 ± 5.3% in group C and 94.7 ± 3.0% in group B (P < 0.05). A significant correlationship was found between free TS and tumor weight (P < 0.05). As the next step, continuous infusion (group C) or daily bolus injection (group B) for 6 days was started on day 5 after implantation of YS cells. The relative increase of tumor on day 9 was 256 ± 111% in group C and 112 ± 22.1% in group B (P < 0.05). On day 11, total TS of the resected tumor was 650 ± 153 fmol/mg protein in group C and 391 ± 124 fmol/mg protein in group B (P < 0.05), and inhibition rate of TS was 78.8 ± 12.4% in group C and 84.4 ± 8.6% in group B. Daily bolus injection of FUra causes a superior antitumor and antimetabolic effect. The schedule dependent cytotoxicity of FUra should be taken into account when a chemotherapeutic protocol is designed. © 1992 Wiley‐Liss, Inc.
Long‐ and short‐term survivors after pancreatoduodenectomy for ampullary carcinoma
Authors: Yamaguchi Koji , Nishihara Kazuyoshi 
Published: February 2007

AbstractOut of 36 consecutive patients who underwent a pancreatoduodenectomy for carcinoma of the ampulla of Vater, eight patients (long‐term survivors) survived more than 5 years after surgery, while eight other patients (short‐term survivors) survived less than 12 months after intervention. Both the eight long‐term survivors and eight short‐term survivors were compared clinicopathologically. The long‐term survivors did have some preferable factors such as a high value of peripheral lymphocytes, a low concentration of carcinoembryonic antigen, a small protruding tumor, a shallow depth of invasion, a well‐differentiated histopathologic type, an infrequent venous invasion, and no perineural infiltration. However, these differences were not significant. A multivariate regression analysis regarding the 18 prognostic variables showed that both perineural invasion and the grade of histopathologic differentiation were significant parameters. Out of the eight long‐term survivors, three patients lived more than 10 years while another died from ampullary carcinoma 74 months after surgery. Pancreatoduodenectomy not only produces long‐term survivors but can also effect a complete cure in patients with ampullary carcinoma. A long clinical follow‐up of more than 5 years after surgical intervention is thus warranted. © 1992 Wiley‐Liss, Inc.
Surgical complications of intraoperative radiation therapy: The radiation therapy oncology group experience
Authors: Noyes R. Dirk , Weiss Steven M. , Krall John M. , Sause William T. , Owens Jake R. , Wolkov Harvey B. , Lanciano Rachelle , Hanks Gerald E. , Hoffmann John 
Published: February 2007

AbstractIntraoperative radiotherapy (IORT) is being used with increasing frequency in many institutions in the United States but little is known about the surgical complication rates. The Radiation Therapy Oncology Group initiated three prospective studies in IORT in 1986 and we report here the experience in advanced malignancies of the stomach, pancreas, and rectum. The incidence and nature of major surgical complications were reviewed and presented with their implications in regard to future IORT trials. Two hundred twenty‐seven patients were entered on three studies by 20 participating institutions between 1985 and 1989. One hundred twenty‐nine patients received IORT while 98 patients were found to have too advanced disease to be benefited by IORT and underwent palliative surgical procedures only. IORT doses ranged from 12–22 Gy and bowel anastomoses were not irradiated. Wound infection in the IORT group was 6% vs. 2% in the non‐IORT patients but this was not significant at the P = 0.05 level. Other complications included anastomotic leak (n = 5), operative bleeding (n = 10), pancreatitis (n = 2), and were not statistically different in the IORT and non‐IORT groups. The mortality rate for the IORT and non‐IORT groups combined was 1.8%. This large multi‐institutional experience in patients with advanced malignancy demonstrates that patients receiving IORT do not have a higher surgical complication rate than those not receiving IORT. Long‐term survival data await the implementation of Phase III trials in advanced intra‐abdominal malignancy. © 1992 Wiley‐Liss, Inc.
Oncological aspect of immediate breast reconstruction in mastectomy patients
Authors: Noguchi Masakuni , Fukushima Wataru , Ohta Nagayoshi , Koyasaki Naohiro , Thomas Michael , Miyazaki Itsuo , Yamada Tetsuji , Nakagawa Masaaki 
Published: February 2007

AbstractIn this study, we compared the relapse‐free and overall survival of 83 patients who underwent mastectomy with immediate reconstruction (MIBR) using a musculocutaneous flap with or without silicone implant with those of 153 patients with breast cancer who underwent mastectomy without immediate reconstruction. In univariate analysis, the overall and/or relapse‐free survival of reconstructed patients with four or more positive axillary lymph nodes or those with menopausal status were significantly inferior compared with those of nonreconstructed patients. In multivariate analysis, however, the immediate breast reconstruction did not appear to have a significant adverse influence on all patients, and on the subgroups stratified by menopausal status or axillary lymph node metastases. Therefore, it was concluded that MIBR using a musculocutaneous flap did not compromise the survival of patients with breast cancer. © 1992 Wiley‐Liss, Inc.
The role of fine needle aspiration in the diagnosis of thyroid nodules: Analysis of 795 consecutive cases
Authors: Piromalli Domenico , Martelli Gabriele , Del Prato Ivan , Collini Paola , Pilotti Silvana 
Published: February 2007

AbstractThe utility of fine needle aspiration (FNA) and physical examination for selecting patients with palpable thyroid nodules for surgery was evaluated in 795 consecutive cases. Surgery was performed in 216 patients based upon the cytological diagnosis and clinical criteria. Excluding 42 patients who were lost to follow‐up, the remaining 537 were regularly followed up (range, 2–10 years). Cytological findings were classified as malignant, histologic control recommended (suspicious), follicular tumor, benign, and unsatisfactory. Thirty‐six aspiration biopsies were positive for malignancy and the diagnosis was confirmed histologically in 34 of them. In 65 patients with final histological diagnosis of malignancy, cytology was positive in 34, suspicious in 20, benign in 3 cases, and unsatisfactory in 8. All patients with cytological diagnosis of follicular tumor had a benign lesion at histology. There were two false positive and three false negative cytological results among the 216 histologically confirmed cases. Excluding unsatisfactory specimen sensitivity, specificity and the predictive value for a positive and a negative result were respectively 95%, 97.5%, 94.5%, and 97%. We conclude that FNA is a very reliable diagnostic test in the evaluation of thyroid nodules and is the best guidance in addition to clinical criteria for selecting patients to be submitted to surgery. © 1992 Wiley‐Liss, Inc.
Adenocarcinoma arising within a gastric duplication cyst
Authors: Coit Daniel G. , Mies Carolyn 
Published: February 2007

AbstractA rare case of carcinoma arising within a gastric duplication cyst in a 72 year old woman is presented. This is the oldest patient in whom neoplastic transformation of this usually benign developmental abnormality has been reported. The clinical and pathologic features of this patient are demonstrated and reviewed in the context of prior reported cases. © 1992 Wiley‐Liss, Inc.
Atrophic chronic gastritis and esophagogastric anastomotic leak after resection and reconstruction for esophageal carcinoma
Authors: Rakic Srdjan , Pesko Predrag , Milicevic Miroslav , Gerzic Zoran 
Published: February 2007

AbstractThe incidence of anastomotic leakage after esophagectomy for cancer and reconstruction with the stomach was analyzed with respect to the presence of coexistent atrophic chronic gastritis (ACG). Of a total of 28 operated esophageal cancer patients with ACG, 6 patients developed an anastomotic leak at the cervical esophagogastrostomy (21%). Of a total of 8 operated esophageal cancer patients none of the patients developed an anastomotic leak. The ACG positive and the ACG negative patients were found to be well matched for age, sex, type of operation, transplant route, level of the anastomoses, and suture technique, and all were operated on by the same surgeons. The difference in leakage rate did not reach statistical significance. © 1992 Wiley‐Liss, Inc.
Quality of life in bone tumor patients comparing limb salvage and amputation of the lower extremity
Authors: Postma Aleida , Kingma Annet , De Ruiter Johan H. , Koops Heimen Schraffordt , Veth René P. H. , Goëken Ludwig N. H. , Kamps Willem A. , Karakousis Constantine P. 
Published: February 2007

AbstractIn 33 long‐term survivors of lower extremity bone cancer quality‐of‐life data were studied following limb salvage compared to amputation. Self‐report questionnaires, semistructured interviews and visual analog scales were used to measure psychoneurotic and somatical distress, activities of daily living, self‐esteem, and adjustment to illness. Fourteen patients with limb salvage (age 13–56 years, median 24) and 19 patients with an amputation (age 21–53 years, median 27) were evaluated 2–17 years (median 10 years) after surgery. The differences between the two groups were not statistically significant. However, physical complaints were reported more often by limb salvage patients, whereas the amputees showed a trend toward lower self‐esteem and isolation in social life, due to their disability. Both groups felt equal diminution of quality of life and disability as measured on the visual analog scale. These findings could support the cosmetic advantage of limb salvage compared to amputation. © 1992 Wiley‐Liss, Inc.
Mucinous component in colorectal carcinoma—prognostic significance: A study in a south Indian population
Authors: Suma Krupa Shankar , Nirmala Vadakkepat , Meyer John S. 
Published: February 2007

AbstractOne hundred eighteen specimens of colorectal carcinoma have been studied with a view to assess the clinicopathological significance of the mucinous component in these neoplasms. When 50% or more of high‐power fields examined consisted of “mucinous” tumour tissue, the term mucinous carcinoma was applied. Such mucinous carcinomas (MCa) constituted 19% of the total neoplasms studied. Predilection for the younger age group, a higher incidence in the proximal colon as against the rectosigmoid, and a lower distribution in the rectosigmoid as against nonmucinous carcinomas in that region were some of the features that characterised MCa. Clinical and histological features suggestive of aggressive behaviour and poor prognosis were more frequently observed in MCa. These features correlated with the percentage of mucinous component independently of the histological grade. It is concluded that colorectal mucinous carcinomas form a distinct group of neoplasms with certain clinical and pathological characteristics. These neoplasms tend to follow an aggressive clinical course, which is directly influenced by the mucinous component. © 1992 Wiley‐Liss, Inc.
Secondary penile malignancies: The spectrum of presentation
Authors: Belville William D. , Cohen Jill A. 
Published: February 2007

AbstractSecondary penile carcinoma is a rare disease with signs and symptoms covering a wide spectrum, from simple erythema to priapism. We report two cases of penile metastatic involvement that are illustrative of this spectrum. © 1992 Wiley‐Liss, Inc.
Prognostic markers of colorectal cancer: An evaluation of DNA content, epidermal growth factor receptor, and Ki‐67
Authors: Hemming Alan W. , Davis Noelle L. , Kluftinger Andreas , Robinson Bruce , Quenville Noel F. , Liseman Babette , Lcriche Jean 
Published: February 2007

AbstractBetween January 1989 and August 1991, 62 patients undergoing resection for colorectal adenocarcinoma were assessed in a prospective fashion on the basis of various tumor characteristics that are thought to indicate prognosis. Parameters measured included epidermal growth factor receptor (EGFr) expression, a cell membrane receptor known to be overexpressed in a variety of tumors, Ki‐67, a monoclonal antibody marker of cell proliferation, as well as flow cytometry and standard histologic examination. Statistical analysis included chi square with Yates correction when appropriate, Wilcoxon W, and multivariate logistic regression. EGFr pasitive tumors were associated with worse Dukes' stage (27% of EGFr negative tumors were Dukes' C or D vs. 58% of EGFr positive tumors, P = 0.03), as well as more aneuploid characteristics by flow cytometry (48% EGFr negative = aneuploid vs. 82% EGFr positive = aneuploid, P = 0.01). Lymphatic invasion was more frequent in EGFr positive tumors (P = 0.03). These factors proved to be independent of each other by multivariate analysis. Ki‐67 did not correlate with any of the measured parameters and was of extremely limited use in the evaluation of the study population. Multivariate analysis indicated that aneuploid tumors were associated with worse Dukes' stage than diploid tumors. Histologic parameters such as lymphatic and vascular invasion as well as histologic grade are compared to the other parameters involved with prognosis. © 1992 Wiley‐Liss, Inc.
Metastatic breast carcinoma presenting as persistent diarrhea
Authors: Gifaldi Amy S. , Petros James G. , Wolfe Gail R. Z. 
Published: February 2007

AbstractPatients with breast carcinoma metastatic to the colon generally present with multiple symptoms, usually pain, vomiting, nausea, and ascites. We describe a patient who presented only with persistent diarrhea, underwent surgery for colon cancer, and, on pathological evaluation of the surgical specimen, was found to have metastatic breast cancer affecting the colon. Metastatic breast cancer should therefore be suspected in patients with a history of breast cancer and diarrhea of unknown cause that is not accompanied by other symptoms. Evaluating such patients by colonoscopy and biopsy would provide important information relevant to choosing between colon surgery and systemic therapy. © 1992 Wiley‐Liss, Inc.
Complications of radical vulvectomy and inguinal lymphadenectomy for the treatment of carcinoma of the vulva
Authors: Ayhan Ali , Tuncer Z. Selçuk , Akarin Rahime , Yücel Işin , Develioǧlu Osman , Mercan Ramazan , Zeyneloǧlu Hulusi 
Published: February 2007

AbstractForty‐two patients with invasive carcinoma of the vulva, subjected to radical vulvectomy and inguinal lymphadenectomy, were evaluated retrospectively. The mean age of patients was 61.6 years. Fifteen patients (35.7%) had complicating medical diseases, the histopathological diagnoses were squamous carcinoma (n = 39), undifferentiated carcinoma (n = l), and malignant melanoma (n = 2). The postoperative morbidity and mortality rates were found to be 73.8% and 11.6%, respectively. © 1992 Wiley‐Liss, Inc.
Cystic neoplasms of the pancreas: A heterogeneous disorder
Authors: Dhir Vinay , Mohandas K. M. , Swaroop Vege Santhi , Krishnamurthy Shanta , Kane Shubhasa , Desai Devendra C. , Nagral Aabha , Jagannath P. , Desouza Luis J. , Pradhan Sultan A. 
Published: February 2007

AbstractCystic neoplasms of the pancreas are rare tumors with a relatively better prognosis as compared to other pancreatic cancers. They may be mistaken for pseudocysts. Seventeen patients who underwent surgical resection were analyzed. Seventy percent of the patients were females and 76.7% of the tumors were located in the tail of the pancreas. Preoperative diagnosis was made on the basis of ultrasonography and/or computed tomography findings in 60% of patients. Retrospective review of the imaging modalities revealed one or more findings suggestive of cystic neoplasms in 90% of the patients. These included multiloculated cysts, thickened cyst wall, intracystic mass or calcifications, and presence of liver metastasis. All the tumors were completely or partly excised. The final histopathological diagnosis was microcystic adenoma in 2, mucinous cyst adenoma in 1, papillary cystic neoplasm in 3, cystic neuroendocrine tumor in 5, and cystadenocarcinoma in 6. Of the 17 patients, 10 had malignant tumors. Seven patients with benign tumors and 3 patients with malignant tumors are disease free 12–30 months after resection. Cystic neoplasm must always be considered as a possibility when dealing with cystic lesions of the pancreas and a careful evaluation of ultrasonography and computed tomo‐graphic scan may give a clue to the diagnosis. © 1992 Wiley‐Liss, Inc.
The effect of vagotomy and pyloroplasty on colorectal tumor induction in the rat
Authors: Nelson Richard L. , Briley Susan , Vaz Octavio P. , Abcarian Hercand 
Published: February 2007

AbstractEpidemiologic studies have suggested that vagotomy increases subsequent colorectal cancer risk. This hypothesis was investigated in the rat 1,2 dimethylhydrazine (DMH) colorectal carcinogenesis model. Eighty‐five rats were divided into four groups having either truncal vagotomy and Heineke‐Mickulicz pyloroplasty, pyloroplasty alone, laparotomy alone, and anesthesia alone. After recovery from the procedures, colon tumors were induced with five injections of DMH. Results of carcinogenesis show a trend towards increased incidence and yield of colorectal and duodenal tumors after vagotomy, though this was not statistically significant, perhaps because the high postoperative mortality from vagotomy diminished the power of the Study. © 1992 Wiley‐Liss, Inc.