bluuebunny/crossref_metadata_2025_split huggingface dataset:
Advanced gastric cancer successfully resected following cisplatin therapy: Report of a case
Authors: Saji Shigetoyo , Kishimoto Yasushi , Sakata Kazuki , Furuta Tomohiko , Tanemura Hiromi , Kawata Ryo 
Published: February 2007

AbstractA case of unresectable advanced gastric cancer was treated with cisdichlorodiammine platinum (CDDP) at a dosage of 30 mg/day for 5 days every month after operation. After three courses of administration, examinations revealed that the tumor had disappeared, and an evaluation of complete response was made. Four months later, a second‐look operation was performed; and it was found that the cancer was smaller than a thumb and could be resected radically. No significant side effects were observed during CDDP therapy.
In vivo ethane production in vitamin E‐deficient rats with DMH‐induced colon cancer
Authors: Slater Gary , Kang Jae , Cohen Gerald , Szporn Arnold , Aufses Arthur H. 
Published: February 2007

AbstractThe effect of both a vitamin E‐deficient and a high polyunsaturated fat (PUFA) diet was tested on rats injected with the colon carcinogen 1,2‐dimethylhydrazine (DMH). In vivo lipid peroxidation was monitored by measuring exhaled ethane from the animals. Higher mean weights were found in animals fed high PUFA and vitamin E‐sufficient diets. There was no difference in ethane exhalation between DMH‐treated and control animals regardless of diet. Mean ethane exhalation was highest in animals fed either vitamin E‐deficient or high PUFA diets. There was no difference in tumor formation between the vitamin E‐deficient and the vitamin E‐sufficient groups. The high PUFA groups had more tumors than the low PUFA groups. Diet was shown to be the major factor affecting ethane exhalation. There was no evidence that vitamin E‐deficiency promoted DMH‐induced tumors or that DMH caused increased lipid peroxidation.
Importance of biologic status to the postoperative prognosis of patients with stage III nonsmall cell lung cancer
Authors: Nakahara Kazuya , Monden Yasumasa , Ohno Kiyoshi , Fujii Yoshitaka , Hashimoto Junpei , Kitagawa Youichiro , Kawashima Yasunaru 
Published: February 2007

AbstractThe prognosis of patients with stage III nonsmall cell lung cancer was studied, with special attention to their biologic status prior to lung resection. The biologic status was estimated from the neutrophil/lymphocyte ratio in the peripheral blood, serum albumin level, and erythrocyte sedimentation rate. Among 46 patients who underwent potentially curative operations, 31 cases of biologic status A or B (more than two parameters normal) revealed 37.6% of a 5‐year survival rate, whereas there was no 5‐year survivor in 15 cases of biologic status C or D (more than two parameters abnormal). Of the 5‐year survival rate in T3N0disease of biologic status A or B, the 60% surviving (of 10 cases) was in marked contrast to the same stage disease of biologic status C or D where only 1 patient (of 10 cases) was still surviving at more than 30 months. In 30 patients with T3N0, T3N1, and T2N2diseases of biologic status A or B, where long‐term survivors were derived, the 5‐year survival rate in 30 patients of biologic status A or B was 36.6% in contrast to no long‐term survivor in the same stage diseases of biologic status C or D (n = 25). We conclude that surgical results in stage III nonsmall cell lung cancer will be beneficial in patients of biologic status A or B, but nonbeneficial in patients with the same stage of biologic status C or D.
Testicular seminoma: Histological findings and their prognostic significance for stage II disease
Authors: Evensen Jan Folkvard , Fosså Sophie Dorothea , Kjellevold Kjell , Lien Hans Henrik 
Published: February 2007

AbstractRisk factors, their interrelationship, and prognostic relevance for seminoma stage II disease have been examined. The size of the primary tumor was significantly correlated with the pT category, as was the presence of tumor invasion of small vessels. The pT category was correlated neither with clinical substage nor relapse rate. There was a poorer 3‐year survival for anaplastic seminomas as compared to that of classical seminomas; the difference was not significant. The 5‐year survival for seminomas rich in lymphocytes was better than those of poor lymphocytic infiltration, but this difference also was not significant. No difference in survival or relapse rate was found between HCG‐producing and HCG‐nonproducing seminomas.
Two‐dimensional immunoelectrophoretic analysis of urinary ultraconcentrates: Antigenic differences between bladder cancer positive patients, normal individuals, and patients with urinary tract infections
Authors: Hewitt Charles W. , Black Kirby S. , Quintero Carolyn S. , Slater Kurt J. , Martin Donald C. 
Published: February 2007

AbstractUrine ultraconcentrates (100‐fold) from bladder cancer patients, patients suffering from urinary tract infection, and normal individuals were analyzed using polyacrylamide gel electrophoresis (PAGE) and two‐dimensional immunoelectrophoresis. A combined sample of normal urine was resolved into 1 to 3 protein bands by PAGE, whereas a single concentrated bladder cancer urine was resolved into 10–12 protein bands. Yet, this same concentrated urine sample was resolved into 17–20 antigen peaks by two‐dimensional immunoelectrophoresis (2DIEP) against antihuman serum. A significant (P < 0.05) increase was observed in the relative antigen concentration when comparing 2DIEP profiles of bladder cancer urines to normal controls. A significant increase in the relative antigen concentration and the number of antigen peaks was also found when comparing immunoelectrophoretic patterns obtained from ultraconcentrated urine specimens of bladder cancer positive urine and normal controls using a rabbit antibladder cancer urine antisera (P < 0.002 and P < 0.02, respectively). In addition, significant (P < 0.02) antigenic differences were found when comparing concentrated urine samples from bladder cancer positive individuals to those with urinary tract infection. The bladder cancer group demonstrated 8/9 positive results for relative antigen concentrations greater than 3.0. Fifteen of 16 normal or urinary tract infected individuals combined had relative antigen concentrations less than 3.0. These differences were highly significant (P < 0.001). No differences were found between concentrated bladder cancer and normal urine specimens tested against rabbit antinormal urine antisera.
Autotransplantation of colonic tumors into the colonic wall of the rat
Authors: Rubio C. , Nylander G. , Wallin B. , Sveander M. , Duvander A. , Alun M. 
Published: February 2007

AbstractColonic tumors were induced in Sprague‐Dawley rats by weekly subcutaneous injections of 1,2 Dimethylhydrazine (DMH) for 4 months. The animals were thereafter laparotomized and a palpable tumor was transplanted into the same animal in a tumor‐free area of the transverse colon. Autotransplanted tumors were considered those tumors growing in the wall of the transverse colon, covered by intact colonic mucosa. The frequency of autotransplanted tumors was 34%. The possibility that auto‐transplantation may also occur in humans by accident, during procedures to remove a colorectal adenocarcinoma, is discussed.
Effect of axillary nodal status on the long‐term survival following mastectomy for breast carcinoma: Nodal metastases may not always suggest systemic disease
Authors: Yang Jung Hyun , Slack Nelson H. , Nemoto Takuma 
Published: February 2007

AbstractRecords of 215 patients receiving radical mastectomies from 1958 to 1968 at Roswell Park Memorial Institute were reviewed for the significance of axillary nodal status on long‐term survival and recurrence. Ten‐year disease‐free interval rates were 83%, 47%, and 17%, respectively, for patients with negative nodes, 1–3 positive nodes, and ≥ 4 positive nodes. Fifteen‐year rates were 80%, 37%, and 8%, respectively. Survival and disease‐free interval curves for the 3 nodal status groups were significantly different from each other (P<0.0001). Curves for three subclasses of the ≥ 4 positive node group (4–6, 7–12, and ≥ 13) were similar in overall survival, but were significantly (P=0.04) different for disease‐free interval, due to a rapid rate of recurrence in the ≥ 13 positive node group. Hazard rates of treatment failure during each successive 3‐year period for 9 years following mastectomy for those with 1–3 positive nodes or ≥ 4 positive nodes decreased with time, whereas the rates for those with negative nodes were low and relatively constant throughout follow‐up. These findings support the thesis that a significant proportion of negative nodes patients are cured by mastectomy and that a smaller group of node‐positive patients have regional disease with a chance of cure by mastectomy.
Epstein‐barr virus related lymphoepithelioma‐like carcinoma of lung
Authors: Bégin Louis R. , Eskandari Jan , Joncas Jean , Panasci Lawrence 
Published: February 2007

AbstractA malignant neoplasm localized to the lung is reported in a rather unusual host: a 40‐year‐old female, nonsmoker, of South‐East Asiatic origin. The histology was of nasopharyngeal‐like carcinoma character and ultrastructural examination confirmed a diagnosis of nonkeratinizing, poorly differentiated squamous cell carcinoma. The clinicopathologic findings were more suggestive of a primary pulmonary origin than the manifestation of an occult nasopharyngeal primary. The immunological profile was highly suggestive of an Epstein‐Barr virus (EBV) associated epithelial neoplasia. This case might widen the spectrum of EBV‐associated neoplasia, by inclusion of lower respiratory tract as a target organ.
Simultaneous endometrioid carcinoma of the uterine corpus and ovary: A clinicopathologic study of 15 cases
Authors: Jambhekar Nirmala A. , Sampat Mrudula B. 
Published: February 2007

AbstractThe clinical stage assigned to simultaneously presenting carcinomas of the uterine corpus and ovary remains variable, depending on which of the two sites is considered to be the primary. Simultaneous involvement may occasionally represent independent primaries, a fact often overlooked. A review of all cases with a tissue diagnosis of carcinoma involving uterus and ovary was undertaken to identify those cases which possibly represent independent primaries. Seventeen such cases were identified on the basis of pathologic features, 15 of which revealed endometrioid type carcinoma at both sites. These 15 patients, who constitute the study group, were treated surgically with or without adjuvant therapy. Thirteen patients have been followed up for 1 to 12 years. Twelve patients are alive and free of disease. Vaginal vault recurrence occurred in a single patient. This was treated successfully. One patient died of an unrelated cause. The good survival fortifies the pathological impression that these cases represent independent primaries.
Surgical considerations in maxillofacial prosthetic rehabiliation of the maxillectomy patient
Authors: Jacobs John R. , Marunick Mark T. 
Published: February 2007

AbstractThe radical maxillectomy performed for cancer of the paranasal sinuses has as its sequella some of the potentially most devastating functional losses in the field of head and neck oncology. The patient is left after surgical management with a defect that often prevents effective speech, deglutition, and mastication. This paper addresses the surgical considerations involved in the performance of a radical maxillectomy that can result in a favorable defect allowing subsequent optimal prosthetic rehabilitation of the patient.
Adenomatoid tumors in the tunica albuginea of the testis
Authors: Arcadi John A. 
Published: February 2007

AbstractAdenomatoid tumors of the tunica albuginea of the testis is rarely seen. Only 15 such cases have been described. A patient is presented in whom such a tumor was found and excised through a scrotal incision. He is alive and well 27 years later. The author presents reasons for the type of scrotal exploration done. The pathological histology is discussed. An adenomatoid tumor can easily be confused with a prostatic adenocarcinoma on frozen section.
Radiation therapy for squamous cell carcinoma of the esophagus
Authors: Harrison Louis B. , Fogel Thomas D. , Picone James R. , Fischer Diana B. , Weissberg Joseph B. 
Published: February 2007

AbstractBetween 1965 and 1981, 119 patients with squamous cell carcinoma of the esophagus were treated with radiation therapy with curative intent. Radiation was employed in combination with surgery and delivered pre‐ and/or postoperatively in 20 patients (17%). The remainder received radiotherapy alone. The overall survival rate was statistically higher in patients who had surgery and radiation compared to the group receiving radiation alone. The one‐, two‐, and five‐year survival rates of patients receiving combined treatment vs radiotherapy alone were 65% vs 35%, 25% vs 14%, and 15 % vs 6%. Age, total radiation dose, and inclusion of the supraclavicular areas in the radiation portals did not impact on outcome. Other prognostic factors are discussed. Long term survivors were noted to be at substantial risk for the development of a second epidermoid malignancy in the upper aerodigestive tract. Cumulative risk at five years was approximately 25%.
Angiogenic activity by spleen cell supernatants from tumor‐bearing and tumor‐resected mice
Authors: Davel Lilia , Miguez Marta , Jasnis María Adela , Eiján Ana María , Oisgold‐Dagá Sara , De Lustig Eugenia Sacerdote 
Published: February 2007

AbstractSupernatants of cultured spleen cells (SCS) from small tumor‐bearing mice (STBM) and large tumor‐bearing mice (LTBM) are able to enhance tumor growth as well as accelerate tumor takes in vivo when inoculated 24 h before tumor implant. After tumor resection enhancing activity disappears at a rate depending on the size of the resected tumor. Spleen cells from tumor‐bearing mice also evoke a complex vascular response, lymphocyte‐induced angiogenesis (LIA) elicited via the release of lymphokines from activated T cells. As angiogenic factors promote tumor development we investigated if SCS from tumor‐bearing and tumor‐resected mice contain factors capable of evoking a LIA response. Angiogenic activity was detected by SCS of small and large tumor‐bearing mice as well as in large tumor‐resected mice. On the other hand, SCS from small tumor‐resected mice are not able to evoke an angiogenic response. Possibly, the large antigenic burden in LTRM stimulate the immune system in a different way than in STRM. We can suggest that the different behavior of spleen cells after small and large tumor removal can be explained by quantitative or qualitative changes in the spleen subpopulations.
Gamma glutamyl transferase activity in rat colon during experimental colonic carcinogenesis
Authors: Traynor O. J. , Lee Y. C. , Whittaker K. B. , Zinsmeister A. R. , Moss D. W. , Wood C. B. 
Published: February 2007

AbstractColonic gamma glutamyl transferase activity is raised in colonic malignancy. This study was undertaken to determine how early and how extensively this raised activity occurs during carcinogenesis. Sixty rats were given weekly injections of dimethylhydrazine for 16 weeks, and 20 rats acted as controls. Groups of treated and control rats were sacrificed at regular intervals during the pre‐cancerous phase of carcinogenesis, and gamma glutamyl transferase activity was measured at several sites in the colon. Gamma glutamyl transferase activity was raised as early as 4 weeks after the first injection of dimethylhydrazine (p < 0.05), and the elevation persisted until the development of overt tumours. The raised gamma glutamyl transferase activity was observed throughout both the proximal and distal colon long before the appearance of macroscopic tumours. We conclude that an early and widespread elevation of colonic gamma glutamyl transferase activity occurs during carcinogenesis. This may have useful applications in the early detection of colonic malignancy.
Parotid lymph node metastases from squamous cell carcinoma of the skin
Authors: Shimm David S. 
Published: February 2007

AbstractNineteen parotid lymph node metastases from squamous cell carcinoma of the skin were treated, seven with irradiation and 12 with surgery and postoperative irradiation. In the group treated with combined therapy, size of nodal metastasis and extent were strong predictors of relapse. Further postoperative irradiation with 60 Gy is not adequate to control extensive parotid nodal disease. Finally, elective treatment of clinically negative parotid nodes is not necessary in patients who can be closely followed, since early nodal disease can be controlled readily.
Intraperitoneal infusion of 5‐FU in liver metastases from colorectal cancer
Authors: Ekberg Henrik , Tranberg Karl‐Göran , Persson Bo , Jeppsson Bengt , Nilsson Lars‐Göran , Gustafson Torbjörn , Andersson Karl‐Erik , Bengmark Stig 
Published: February 2007

AbstractIntraperitoneal 5‐fluorouracil (5‐FU) was given to eight patients with unresectable colorectal liver cancer and to one patient after radical hepatectomy. A subcutaneous Intraperitoneal access device was implanted, and treatment consisted of continuous infusion of 1,000 mg 5‐FU/d for 5 days, repeated every 6 weeks. Evaluation of treatment was performed after every two cycles of therapy. A total of 32 infusion cycles were given. The mean steady‐state concentration of 5‐FU was 0.56 ± 0.04 μmo1/1 (mean ± SEM), and the total body clearance was 10.0 ± 0.71/min (mean ± SEM). The levels of 5‐FU in peripheral venous blood were stable and reproducible. When incubated in whole blood at 37°C the concentration of 5‐FU fell rapidly and after 2h, only 22% of the starting level remained. When kept ice‐cold, 5‐FU samples were stable. Patient acceptance was excellent, and the therapy was free from complications except for slight abdominal discomfort, not enough to require alleviation by analgesic drugs. Computerized tomography (CT) scan showed stationary tumor volume after two cycles of therapy in four of eight patients who could be evaluated. It is concluded that continuous intraperitioneal infusion of 5‐FU produces stable and reproducible levels of the drug in peripheral venous blood, that 5‐FU is degraded by blood cells at 37°C, that the use of a subcutaneous access device makes the delivery easy and safe, and that the efficacy of the therapy seems to be similar to that obtained with hepatic arterial infuson.
The effect of prior adjuvant chemotherapy on survival in metastatic breast cancer
Authors: Ahmann Frederick R. , Jones Stephen E. , Moon Thomas E. 
Published: February 2007

AbstractSome adjuvantly treated patients develop recurrent breast cancer and little is known about the effect of prior adjuvant chemotherapy on subsequent response rates to systemic therapy or on overall survival. We describe our retrospective comparison of 179 patients who received doxorubicin containing adjuvant chemotherapy and developed recurrent breast cancer on University of Arizona Cancer Center clinical trials with 202 non‐adjuvantly treated patients entered onto clinical protocols for recurrent or metastatic breast cancer during the same period. Adjuvant failures had a shorter median survival from the date of onset of recurrent disease (18 months versus 28 months, P < 0.001), a lower response rate to initial combination chemotherapy (38% versus 69%, P = 0.001), and a high incidence of CNS involvement at the time of relapse (11%). In patients having recurrent or metastatic breast cancer, a history of prior adjuvant chemotherapy appears to identify a subgroup who will have a higher incidence of CNS involvement, a lower response rate to chemotherapy and a shorter survival with metastatic disease. These findings may help explain the failure of improved relapse free survival seen in many adjuvant chemotherapy trials to result in improved overall survival.
Antibody to the aids virus in Kaposi's sarcoma in Nigeria
Authors: Otu Akpan A. 
Published: February 2007

AbstractThe present study has investigated whether Kaposi's sarcoma (KS) in Nigeria is associated with infection with the AIDS virus variously called human T‐cell lymphotropic virus type III (HTLV‐III), lymphadenopathy/ AIDS virus (LAV), and AlDS‐associated retrovirus (ARV). Serum samples from 40 KS patients, 30 patients with malignant melanoma of the foot (contemporaneous controls), and 50 normal nontumour‐bearing controls were tested for anti‐AIDS virus antibody by enzyme‐linked immunosorbent assay (ELISA). The assay consistently and reproducibly failed to show seropositivity in all the patients and controls. These results show that Kaposi's sarcoma in Nigeria is not associated with infection with the AIDS virus and that the virus is not endemic in this region.
The value of tumour marker kinetics in the management of patients with primary hepatocellular carcinoma
Authors: Buamah P. K. , James O. F. W. , Skillen A. W. , Harris A. L. 
Published: February 2007

AbstractSerum alpha‐fetoprotein (AFP) has been measured during chemotherapy of ten patients with hepatocellular carcinoma. Whenever the AFP concentration of a sample was lower than that of the previous sample the apparent half‐life (AHL) of the protein was calculated. The biological half‐life of AFP is 5 days so that values in excess of this were indicative of continuing or increased synthesis and secretion of AFP. The AHL for AFP provided a means of assessing efficacy of treatment. Increases in AHL generally predicted a rise in serum AFP and give advance warning of the need to change therapy.
Establishment and characterization of a human urinary bladder carcinoma cell line (TSGH‐8301)
Authors: Yeh Ming‐Yang , Yü Dah‐Shyong , Chen Shan‐Chun , Lin Ming‐Shan , Chang Sun‐Yran , Ma Cheng‐Ping , Han Shou‐Hwa 
Published: February 2007

AbstractA cell line derived from a well‐differentiated human transitional cell carcinoma of the urinary bladder, designated TSGH‐8301, was established in vitro. The cultured epithelioid cells exhibited monolayer growth and loss of contact inhibition. The tumorigenicity of TSGH‐8301 had been shown by growth in soft agar and tumor induction in athymic nude mice. A reverse ratio of lactate dehydrogenase (LHD) isoenzyme in the cell line and nude mouse‐grown tumors was seen predominantly with LDH‐V. Chromosomal analysis revealed a heterodiploid stem line with a modal number of 50. Sera of urinary bladder cancer patients reacted with membrane antigens of the TSGH‐8301 cells, suggesting the existence of tumor‐associated antigens in the cells. In vitro chemosensitivity tests of these cells may provide data valuable in the selection of proper anticancer drugs for the TSGH‐8301 donor patient.