bluuebunny/crossref_metadata_2025_split huggingface dataset:
Academics in a New Work Environment: the Impact of New Public Management on Work Conditions
Authors: Santiago Rui , Carvalho Teresa 
Published: July 2008

AbstractNew public management (NPM) approaches have informed policy in the public sector in advanced countries in the last decade. Some authors suggest that the main objective of NPM at the organisational level is to change the traditional way professionals are regulated. This study examines the impact of NPM on the working conditions of Portuguese higher education academics. The empirical data are based on official statistics, and the analysis leads to the following conclusions. Changes have been slow, but already reveal a corrosion of traditional employment practices. Employment has become more precarious as professionals are increasingly employed on non‐tenured contracts. This tendency is more evident in the polytechnic sector. In short, this means that the growth in skilled employment in higher education in Portugal is based on precarious employment relations.
Impact of Institutional Changes on Hungarian Higher Education after 1989
Authors: Berde Éva , Ványolós István 
Published: July 2008

AbstractThis study uses data summaries and interviews to analyse changes in Hungarian higher education since 1989. The first part of the article relies on statistical data and puts the Hungarian higher education system into the international context. It focuses on enrolment changes, spending patterns and the number and quality of teaching personnel. Available data suggest a dramatic increase in enrolment, coupled with declining or stagnant resources. The second part of the study focuses on micro‐level activities of selected universities and departments, with special emphasis on research, teaching, administration and institutional change. The study argues that the creation of a stable, performance‐oriented, well‐financed higher education system in ex‐socialist Hungary has been achieved imperfectly.
Effectiveness and safety of a prevention‐of‐flare‐progression strategy with pimecrolimus cream 1% in the management of paediatric atopic dermatitis
Authors: Sigurgeirsson B , Ho V , Ferrándiz C , Andriano K , Grinienko A , Jimenez P ,   for the Pimecrolimus 1% cream in (paediatric) Eczema: Prevention of Progression multi‐centre investigator study group
Published: July 2008

AbstractObjective  This study was performed to investigate the efficacy and safety of a prevention‐of‐flare‐progression strategy with pimecrolimus cream 1% in children and adolescents with atopic dermatitis (AD).Methods  A 26‐week multi‐centre, randomized, double‐blind, vehicle‐controlled study was conducted in 521 patients aged 2–17 years, with a history of mild or moderate AD, who were clear/almost clear of disease before randomization to pimecrolimus cream 1% (n = 256) or vehicle cream (n = 265). Twice‐daily treatment with study medication was started at the first signs and/or symptoms of recurring AD. If, despite the application of study medication for at least 3 days, AD worsened (as confirmed by the investigator), treatment with a moderately potent topical corticosteroid (TCS) was allowed in both groups. The primary efficacy end point was the number of days on study without TCS use for a flare.Results  The mean number of TCS‐free days was significantly higher (P < 0.0001) in the pimecrolimus cream 1% group (160.2 days) than in the control group (137.7 days). On average, patients on pimecrolimus cream 1% experienced 50% fewer flares requiring TCSs (0.84) than patients on vehicle cream (1.68) (P < 0.0001). Patients on pimecrolimus cream 1% also had fewer unscheduled visits (87) than patients on vehicle cream (246).Conclusions  In children and adolescents with a history of mild or moderate AD but free/almost free of signs or symptoms of the disease, early treatment of subsequent AD exacerbations with pimecrolimus cream 1% prevented progression to flares requiring TCS, leading to fewer unscheduled visits and reducing corticosteroid exposure.
A clinical study comparing methyl aminolevulinate photodynamic therapy and surgery in small superficial basal cell carcinoma (8–20 mm), with a 12‐month follow‐up.
Authors: Szeimies RM , Ibbotson S , Murrell DF , Rubel D , Frambach Y , De Berker D , Dummer R , Kerrouche N , Villemagne H ,   on behalf of the Excilight Study Group
Published: July 2008

AbstractObjective  To compare the efficacy and cosmetic outcome (CO) of photodynamic therapy with topical methyl aminolevulinate (MAL‐PDT) with simple excision surgery for superficial basal cell carcinoma (sBCC) over a 1‐year period.Methods  In this multicentre, randomised, controlled, open study, patients were treated at baseline either with MAL‐PDT (two sessions, 7 days apart, repeated 3 months later if incomplete clinical response) or surgery (at baseline). Primary endpoints were clinical lesion response (CR) 3 months after last treatment and CO assessed by the investigator 12 months after last treatment. Secondary endpoints were CR at 12 months (i.e. recurrence) and CO assessed by the investigator at 3 and 6 months and by the patient at 3, 6 and 12 months.Results  Overall, 196 patients were enrolled with 1.4 sBCC lesions on average per patient. Mean lesion count reduction at 3 months was 92.2% with MAL‐PDT vs. 99.2% with surgery [per protocol (PP) population] confirming the non‐inferiority hypothesis (95% confidence interval, –12.1, –1.9). A total of 92.2% lesions showed CR at 3 months with MAL‐PDT vs. 99.2% with surgery (PP population). At 12 months, 9.3% lesions recurred with MAL‐PDT and none with surgery. CO was statistically superior for MAL‐PDT at all time points. At 12 months, 94.1% lesions treated with MAL‐PDT had an excellent or good CO according to the investigator compared with 59.8% with surgery. This difference was confirmed with the patients’ assessment. The proportion of excellent CO markedly improved with time with MAL‐PDT unlike surgery.Conclusions  MAL‐PDT offers a similarly high efficacy and a much better CO than simple excision surgery in the treatment of sBCC.
Isolated and concurrent prevalence of sensitization to transition metals in a Spanish population
Authors: Bordel‐Gómez MT , Miranda‐Romero A , Castrodeza‐Sanz J 
Published: July 2008

AbstractBackground  Positive patch test results to transition metals (nickel sulphate, palladium chloride, cobalt chloride and potassium dichromate) alone and in combinations with one another are well known. Numerous factors may play a role in isolated and concurrent sensitization to these allergens.Objetive  This study aims to describe the isolated and concurrent prevalence of sensitization to transition metals in a Spanish Dermatology Department, between 2000 and 2005, and to determine the prevalence of concomitant positive patch test reactions to different transitional metals.Patients/methods  Patients (N= 1092) were tested with the standard series of our Allergic Contact Unity, using a standardized technique. Data from these patients were recorded on a computer entry form and analysed. Statistical analyses to evaluated associations of metal contact allergy were performed, and we evaluated the concordance among these associations of transition metals.Results  Three hundred twenty (29.3%) patients reacted positively to nickel, 128 (11.7%) to palladium, 118 (10.8%) to cobalt and 82 (7.5%) to chromium. The prevalence of positive reactions to metals was 32.4%. The association of palladium–nickel was the most frequent, with an acceptable concordance (k= 0.46).Conclusion  This study illustrates that concomitant positive patch test reactions to different transitional metals are frequently seen in patients with allergic contact dermatitis. Our results reflect the high prevalence of sensitization to nickel in Spain.
A Whole Genome Linkage Scan Identifies Multiple Chromosomal Regions Influencing Adiposity‐Related Traits among Samoans
Authors: Dai F. , Sun G. , Åberg K. , Keighley E. D. , Indugula S. R. , Roberts S. T. , Smelser D. , Viali S. , Jin L. , Deka R. , Weeks D. E. , McGarvey S. T. 
Published: July 2008

SummaryWe conducted a genome‐wide scan in 46 pedigrees, with 671 phenotyped adults, from the independent nation of Samoa to map quantitative trait loci (QTLs) for adiposity‐related phenotypes, including body mass index (BMI), abdominal circumference (ABDCIR), percent body fat (%BFAT), and fasting serum leptin and adiponectin. A set of 378 autosomal and 14 X chromosomal microsatellite markers were genotyped in 572 of the adults. Significant genetic correlations (0.82–0.96) were detected between pairs of BMI, ABDCIR, %BFAT and leptin. Suggestive linkages were found on 13q31 (LOD = 2.30 for leptin, LOD = 2.48 for %BFAT, LOD = 2.04 for ABDCIR, and LOD = 2.09 for BMI) and on 9p22 (LOD = 3.08 for ABDCIR and LOD = 2.53 for %BFAT). Furthermore, bivariate linkage analyses indicated that the genetic regions on 9p22 (bivariate LOD 2.35–3.10, LODeq (1df) 1.88–2.59) and 13q31 (bivariate LOD 1.96–2.64, LODeq 1.52–2.21) might harbor common major genes with pleiotropic effects. Other regions showing suggestive linkage included 4q22 (LOD = 2.95) and 7p14 (LOD = 2.64) for %BFAT, 2q13 for adiponectin (LOD = 2.05) and 19q12 for BMI‐adjusted leptin (LOD = 2.03). Further fine mapping of these regions may help identify the genetic variants contributing to the development of obesity in Samoan adults.
Anatomy of the nasal profile
Authors: Anderson K. J. , Henneberg M. , Norris R. M. 
Published: July 2008

AbstractThere is a lack in the understanding of the variation within the thickness of the soft tissue structures (muscle, skin and fat) overlying the cartilaginous skeleton of the nose and their relationship to the dorsum shape. We examined such relationships by dissecting noses of six adult female and six adult male cadavers, comparing the internal anatomical structures to the external nasal profile. We found that the soft tissue structures differ in thickness along the dorsum and that these differences are individualized. Specifically, continuous presence of subcutaneous fat from root to tip was found in half the sample, one nose had fat only on the tip, another one only on the root, the four others at both positions. The nasalis muscle was identifiable in nine of the 12 noses, transversing the nose in half the sample, and in the remaining three, only the lateral section of the muscle was identified. The superior border of the septal cartilage does not form a linear extension of the profile contour of the nasal bones but angles downwards. The actual profile contour of the dorsum does not follow the profile of the nasal bones or the septal cartilage. These results may influence the current use of nasal guidelines in forensic facial approximation.
G1 to S phase cell cycle transition in somatic and embryonic stem cells
Authors: Neganova Irina , Lako Majlinda 
Published: July 2008

AbstractIt is well known that G1 to S phase transition is tightly regulated by the expression and phosphorylation of a number of well‐characterized cyclins, cyclin‐dependent kinases and members of the retinoblastoma gene family. In this review we discuss the role of these components in regulation of G1 to S phase transition in somatic cells and human embryonic stem cells. Most importantly, we discuss some new tenable links between maintenance of pluripotency and cell cycle regulation in embryonic stem cells by describing the role that master transcription factors play in this process. Finally, the differences in cell cycle regulation between murine and human embryonic stem cells are highlighted, raising interesting questions regarding their biology and stages of embryonic development from which they have been derived.
The vomeronasal organ of the tammar wallaby
Authors: Schneider Nanette Y. , Fletcher Terence P. , Shaw Geoff , Renfree Marilyn B. 
Published: July 2008

AbstractThe vomeronasal organ is the primary olfactory organ that detects sexual pheromones in mammals. We investigated the anatomy of the vomeronasal organ of the tammar wallaby (Macropus eugenii), a small macropodid marsupial. Pheromones may be important for activation of the hypothalamo‐pituitary axis of tammar males at the start of the breeding season because plasma testosterone and luteinizing hormone concentration in males rise concurrently with pregnancy and the post‐partum ovulation in females. The gross anatomy and the connection to the brain of the vomeronasal organ were examined by light and electron microscopy in adult male and female tammars. The vomeronasal organ was well developed in both sexes. The vomeronasal organ is a tubular organ connected at the rostral end via the nasopalatine duct (incisive duct) to the mouth and nasal cavity. At the rostral end the lumen of the vomeronasal organ was crescent shaped, changing to a narrow oval shape caudally. Glandular tissue associated with the vomeronasal organ increased towards the blind end of the organ. The tammar has the typical pattern of mammalian vomeronasal organs with electron‐dense supporting cells and electron‐lucent receptor cells. Microvilli were present on the surface of both epithelia while cilia were only found on the surface of the non‐receptor epithelium. Some non‐receptor epithelial cells appeared to secrete mucus into the vomeronasal organ lumen. The vomeronasal organ shows a high degree of structural conservation compared with eutherian mammals. The degree of vomeronasal organ development makes it likely that, as in other mammals, pheromones are important in the reproduction of the tammar.
Laminar and cytoarchitectonic features of the cerebral cortex in the Risso's dolphin (Grampus griseus), striped dolphin (Stenella coeruleoalba), and bottlenose dolphin (Tursiops truncatus)
Authors: Furutani Rui 
Published: July 2008

AbstractThe present investigation carried out Nissl, Klüver‐Barrera, and Golgi studies of the cerebral cortex in three distinct genera of oceanic dolphins (Risso's dolphin, striped dolphin and bottlenose dolphin) to identify and classify cortical laminar and cytoarchitectonic structures in four distinct functional areas, including primary motor (M1), primary sensory (S1), primary visual (V1), and primary auditory (A1) cortices. The laminar and cytoarchitectonic organization of each of these cortical areas was similar among the three dolphin species. M1 was visualized as five‐layer structure that included the molecular layer (layer I), external granular layer (layer II), external pyramidal layer (layer III), internal pyramidal layer (layer V), and fusiform layer (layer VI). The internal granular layer was absent. The cetacean sensory‐related cortical areas S1, V1, and A1 were also found to have a five‐layer organization comprising layers I, II, III, V and VI. In particular, A1 was characterized by the broadest layer I, layer II and developed band of pyramidal neurons in layers III (sublayers IIIa, IIIb and IIIc) and V. The patch organization consisting of the layer IIIb‐pyramidal neurons was detected in the S1 and V1, but not in A1. The laminar patterns of V1 and S1 were similar, but the cytoarchitectonic structures of the two areas were different. V1 was characterized by a broader layer II than that of S1, and also contained the specialized pyramidal and multipolar stellate neurons in layers III and V.
Human 2D (index) and 4D (ring) finger lengths and ratios: cross‐sectional data on linear growth patterns, sexual dimorphism and lateral asymmetry from 4 to 60 years of age
Authors: Gillam L. , McDonald R. , Ebling F. J. P. , Mayhew T. M. 
Published: July 2008

AbstractHuman 2D : 4D ratios (measures of the relative lengths of index and ring fingers) attract considerable research interest because they exhibit sexual dimorphism and are associated with various morphological, physiological and behavioural traits as well as sporting abilities and medical conditions. In an attempt to identify potential confounding factors in such studies, we have examined how relative and absolute digit lengths vary with gender and tested whether they are influenced by age, right–left asymmetry and hand preference. Participants between 4 and 60 years of age were recruited from local educational sites. Hand photocopies and calliper measurement were used to obtain digit lengths. We employed linear regression analysis to examine the growth trajectories of individual digits, analyses of variance to isolate main and interaction effects of age, gender and hand preference, and paired t‐tests to identify lateral asymmetries. Both digits exhibited biphasic growth with an early growth phase followed by a stable length phase. Digits in females attained their maximum length about 2.2 years (dextral subjects) or 5.1 years (sinistral subjects) earlier than those in males. Sexual dimorphism in 2D : 4D ratios was apparent by 4 years of age and age changes in ratios depended on gender, side and hand preference. Relative and absolute lengths displayed age, gender, hand‐preference and age × gender interaction effects. Lengths tended to be greater in females in younger subjects and greater in males in older subjects. Ratios tended to be greater in sinistral subjects. In dextral subjects, significant lateral asymmetries in 2D lengths were seen at all ages but asymmetries in males and 4D lengths seemed to be age‐dependent. We conclude that age, lateral asymmetry and hand preference are potential confounding factors and that future study designs should take account of these as well as other known confounders such as ethnicity, birth order, menstrual cycle phase and sexual preference.
The marbled crayfish: a new model organism for research on development, epigenetics and evolutionary biology
Authors: Vogt G. 
Published: July 2008

AbstractModel organisms have contributed significantly to the understanding of basic biological phenomena. Suitable animal models are at hand for some research disciplines like genetics, development and cell biology but are still sought after for others like epigenetics. Research of the last years has revealed that the marbled crayfish (Marmorkrebs), which was discovered in the mid‐1990s, meets researchers' demands for a vigorous, genetically identical and eurytopic laboratory model very well. Its most prominent advantages are production of high numbers of genetically identical offspring, stepwise alteration of the phenotype by moulting, complex morphology and behaviour and sequential generation of segments and limbs. This paper first reviews the discovery and research history of the marbled crayfish, its biology and culture and its special advantages. It then discusses, based on the published data, its suitability as a laboratory model for various research disciplines. The greatest potential of the marbled crayfish lies in epigenetics and environmental epigenomics and in stem cell research and regeneration. The marbled crayfish also appears to be suitable for the investigation of the role of stochastic developmental variation and epigenetic inheritance in evolution and to contribute to evo‐devo and eco‐devo. This unique crayfish is even of some value for applied biologists, for example as a toxicological test species.
Desiccation tolerance in embryonic stages of the tardigrade
Authors: Schill R. O. , Fritz G. B. 
Published: July 2008

AbstractDesiccation tolerance commonly found among tardigrades allows them to cope with temporal variation of available water. Although the long‐term survival of adults has been demonstrated in several species, desiccation tolerance of eggs and embryos is less well studied, however it is an important aspect from an ecological and evolutionary point of view. For the first time we evaluated the desiccation tolerance and subsequent hatching success of five different developmental stages of the tardigrade species Milnesium tardigradum, when rehydrated following drying at eight different humidity levels (10, 20, 31, 40, 54, 59, 72, 81%). Humidity level and developmental stage are significant factors in determining successful hatch rates. The results showed that the less developed stages were quite sensitive to desiccation. Low humidity levels during the first 3 days of development lead to a decrease in hatch rates following rehydration. Later developmental stages showed higher hatch rates than embryos dried at earlier stages. However, fast drying at low humidity levels resulted in delayed development and lower hatch rates following rehydration. In general, further developed embryos exhibit a better survival capacity compared with younger stages.
Premature centromere division of the X chromosome in neurons in Alzheimer’s disease
Authors: Spremo‐Potparević Biljana , Živković Lada , Djelić Ninoslav , Plećaš‐Solarović Bosiljka , Smith Mark A. , Bajić Vladan 
Published: July 2008

AbstractPremature centromere division (PCD) represents a loss of control over the sequential separation and segregation of chromosome centromeres. Although first described in aging women, PCD on the X chromosome (PCD,X) is markedly elevated in peripheral blood lymphocytes of individuals suffering from Alzheimer disease (AD). The present study evaluated PCD,X, using a fluorescentin situhybridization method, in interphase nuclei of frontal cerebral cortex neurons from sporadic AD patients and age‐matched controls. The average frequency of PCD,X in AD patients (8.60 ± 1.20%) was almost three times higher (p < 0.01) than in the control group (2.96 ± 1.20). However, consistent with previous studies, no mitotic cells were found in neurons in either AD or control brain, suggesting an intrinsic inability of post‐mitotic neurons to divide. In view of the fact that it has been well‐documented that neurons in AD can re‐enter into the cell division cycle, the findings presented here of increased PCD advance the hypothesis that deregulation of the cell cycle may contribute to neuronal degeneration and subsequent cognitive deficits in AD.
Modulation of the neuronal response to ischaemia by somatostatin analogues in wild‐type and knock‐out mouse retinas
Authors: Cervia Davide , Martini Davide , Ristori Chiara , Catalani Elisabetta , Timperio Anna Maria , Bagnoli Paola , Casini Giovanni 
Published: July 2008

AbstractSomatostatin acts at five G protein‐coupled receptors, sst1‐sst5. In mouse ischaemic retinas, the over‐expression of sst2 (as in sst1 knock‐out mice) results in the reduction of cell death and glutamate release. In this study, we reported that, in wild‐type retinas, somatostatin, the multireceptor ligand pasireotide and the sst2 agonist octreotide decreased ischaemia‐induced cell death and that octreotide also decreased glutamate release. In contrast, cell death was increased by blocking sst2 with cyanamide. In sst2 over‐expressing ischaemic retinas, somatostatin analogues increased cell death, and octreotide also increased glutamate release. To explain this reversal of the anti‐ischaemic effect of somatostatin agonists in the presence of sst2 over‐expression, we tested sst2 desensitisation because of internalisation or altered receptor function. We observed that (i) sst2 was not internalised, (ii) among G protein‐coupled receptor kinases (GRKs) and regulators of G protein signalling (RGSs), GRK1 and RGS1 expression increased following ischaemia, (iii) both GRK1 and RGS1 were down‐regulated by octreotide in wild‐type ischaemic retinas, (iv) octreotide down‐regulated GRK1 but not RGS1 in sst2 over‐expressing ischaemic retinas. These results demonstrate that sst2 activation protects against retinal ischaemia. However, in the presence of sst2 over‐expression sst2 is functionally desensitised by agonists, possibly because of sustained RGS1 levels.