bluuebunny/crossref_metadata_2025_split huggingface dataset:
Accuracy of positron emission tomography in the evaluation of patients treated with chemoradiotherapy for mucosal head and neck cancer
Authors: Martin Richard C. W. , Fulham Michael , Shannon Kerwin F. , Hughes Ceri , Gao Kan , Milross Chris , Tin Mo Mo , Jackson Michael , Clifford Anthony , Boyer Michael J. , O'Brien Christopher J. 
Published: December 2008

AbstractBackgroundThe aim of this study was to evaluate the accuracy of positron emission tomography (PET) in assessing the patients treated with primary chemoradiotherapy for mucosal carcinoma of the head and neck.MethodsA retrospective review of patients with biopsy‐proven cancer of mucosal head and neck sites receiving chemoradiotherapy with curative intent was undertaken.ResultsSeventy‐eight patients met the study criteria. Staging PET identified unsuspected distant metastatic disease in 11% of patients. Sixty‐one patients (78%) had a complete metabolic response on PET, with 17 showing residual disease. Sensitivity of PET was 82% (positive predictive value: 82%) and specificity was 95% (negative predictive value: 95%). Accuracy of PET response was significantly better than clinical assessment and conventional imaging (p< .002,p< .001, respectively).ConclusionPET has been found to be significantly better than clinical examination or conventional imaging in restaging patients after chemoradiotherapy. Patients with a complete response on posttreatment PET have a significant survival advantage and can be safely observed. © 2008 Wiley Periodicals, Inc. Head Neck, 2009
Closure of tracheoesophageal fistula with prefabricated revascularized bilaminar radial forearm free flap
Authors: Wreesmann Volkert B. , Smeele Ludi E. , Hilgers Frans J. M. , Lohuis Peter J. F. M. 
Published: December 2008

AbstractBackgroundTracheoesophageal fistula (TEF) is a rare but serious complication associated with high mortality rates. Traditional management of TEF includes primary closure with or without interposition of regional tissue flaps but is associated with a significant recurrence risk, especially in case of larger fistulas. Application of microvascular free flap reconstruction is an emerging alternative in the surgical management of large TEFs, but may be limited by issues of flap bulkiness and requirement for neoepithelialization across the large inner flap surface.Methods and ResultsHere, we report prefabrication of a bilaminar radial forearm free flap to successfully close a large recurrent TEF that occurred years after tracheoesophageal puncture‐based voice rehabilitation in a laryngectomized patient.ConclusionThe bilaminar radial forearm free flap may prove to be an important adjunct to the closure of large TEFs. © 2008 Wiley Periodicals, Inc. Head Neck, 2009
Genome‐wide analysis of genetic changes in intestinal‐type sinonasal adenocarcinoma
Authors: Hermsen Mario A. , Llorente José Luis , Pérez‐Escuredo Jhudit , López Fernando , Ylstra Bauke , Álvarez‐Marcos César , Suárez Carlos 
Published: December 2008

AbstractBackgroundIntestinal‐type sinonasal adenocarcinomas are rare tumors related to professional exposure to wood dust. Little is known about the genetic changes in these tumors.MethodsTwenty‐two tumors were analyzed by microarray comparative genomic hybridization (CGH). In addition, DNA ploidy was measured by flow cytometry and microsatellite instability (MSI) by multiplex PCR.ResultsThe most frequent gains were, in descending order, as follows: 5p15, 20q13, and 8q24. Losses occurred most frequently at 4q31‐qter, 18q12‐22, 8p12‐pter, and 5q11‐qter. MSI was not detected. Seven cases that harbored very few changes were mostly DNA diploid and had more favorable clinicopathological features, such as lack of intracranial invasion, less metastases, and longer overall survival.ConclusionThe microarray CGH results enabled to better define hotspots of chromosomal gains and losses for further investigation of genes involved in the tumorigenesis of sinonasal adenocarcinoma. In addition, the data allowed classification of a group of patients with better clinical outcome. © 2008 Wiley Periodicals, Inc. Head Neck, 2009
Analysis of postoperative complications of open partial laryngectomy
Authors: Ganly Ian , Patel Snehal G. , Matsuo Jeanette , Singh Bhuvanesh , Kraus Dennis H. , Boyle Jay , Wong Richard , Shaha Ashok R. , Shah Jatin P. 
Published: December 2008

AbstractBackgroundThe objective of this study was to report the incidence of postoperative complications for partial laryngectomy and to identify patient‐ and tumor‐related factors predictive of postoperative complications.MethodsA total of 150 patients who had a partial laryngectomy were identified from an existing database of 662 patients treated for squamous cell carcinoma of the larynx from 1984 to 1998. Postoperative complications were recorded and categorized into local, swallowing, airway, and systemic complications. Patient‐ and tumor‐related predictors of complications were identified by univariate and multivariate analyses.ResultsThere was no postoperative mortality. Twenty percent of patients developed a postoperative complication following partial laryngectomy. Local complications were the most frequent complication and occurred in 17 (11%) patients. Laryngocutaneous fistula occurred in 6 (4%) patients. Multivariate analysis showed that prior radiation was an independent predictor of local complications and laryngocutaneous fistula with a 13‐fold increase in relative risk for both.ConclusionPartial laryngectomy following radiotherapy was more frequently associated with postoperative complications. Problems related to local wound healing, especially the development of laryngocutaneous fistula, constituted the most common postoperative complication in these patients. © 2008 Wiley Periodicals, Inc. Head Neck, 2009
Cell cycle and viral and immunologic profiles of head and neck squamous cell carcinoma as predictable variables of tumor progression
Authors: Rittà Massimo , De Andrea Marco , Mondini Michele , Mazibrada Jasenka , Giordano Carlo , Pecorari Giancarlo , Garzaro Massimiliano , Landolfo Vincenzo , Schena Marina , Chiusa Luigi , Landolfo Santo 
Published: December 2008

AbstractBackgroundThe aim of this study was to determine whether the aberrant expression of cell‐cycle or immune‐response markers together with human papillomavirus (HPV) positivity impacts patient survival in different head and neck squamous cell carcinoma (HNSCC) subsets.MethodsA total of 59 HNSCC specimens were analyzed for expression of cell cycle and proliferation markers, and macrophage infiltration. HPV was evaluated by polymerase chain reaction and DNA sequencing.ResultsThe HPV presence in oropharynx carcinoma was associated with survival advantage. Low Ki67 expression was associated with favorable outcome in oropharynx and oral cavity carcinoma. A more favorable outcome was associated with low cyclin E expression in larynx carcinoma and with low p53 expression in squamous cell carcinoma (SCC) of the oral cavity. A direct correlation between macrophage infiltration and tumor proliferation index was observed irrespective of the tumor subset.ConclusionsThe assessment of proliferation, viral, and immunologic profiles may be crucial to finding beneficial treatments for the different HNSCC subsets. © 2008 Wiley Periodicals, Inc. Head Neck, 2009
Presence of HPV type 6 in dysplasia and carcinoma arising from recurrent respiratory papillomatosis
Authors: Jeong Woo‐Jin , Park Seok‐Woo , Shin Miwha , Lee You Jeong , Jeon Yoon Kyung , Jung Young Ho , Hun Hah J. , Kwon Tack‐Kyun , Song Yong‐Sang , Kim Kwang Hyun , Sung Myung‐Whun 
Published: December 2008

AbstractBackgroundWe collected rare cases of recurrent respiratory papillomatosis (RRP) undergoing malignant transformation. We sought to identify human papillomavirus (HPV) subtypes in areas of papilloma, dysplasia, and carcinoma and investigate thve pattern of protein overexpression.MethodsThree patients whose disease underwent malignant transformation from RRP to carcinoma were subjected to this study. Morphologically distinct areas in the pathology specimen of each patient were diagnosed as papilloma, dysplasia, and carcinoma. Each lesion was separately obtained by laser capture microdissection and was PCR amplified for the presence of HPV. A DNA chip was used to determine the type of HPV in each area. Immunohistochemistry for p53, Ki‐67, and pRb was performed.ResultsHPV type 6 was present in all specimens tested positive. Expression of p53 and Ki‐67 increased with increasing severity of dysplastic change.ConclusionAlthough HPV type 11 is most frequently associated with malignant change of RRP, HPV type 6 may also contribute to play an equally important role in RRP carcinogenesis. © 2008 Wiley Periodicals, Inc. Head Neck, 2009
Intratumoral interferon regulatory factor (IRF)‐1 but not IRF‐2 is of relevance in predicting patient outcome in ovarian cancer
Authors: Zeimet Alain G. , Reimer Daniel , Wolf Dominik , Fiegl Heidi , Concin Nicole , Wiedemair Annemarie , Wolf Anna M. , Rumpold Holger , Müller‐Holzner Elisabeth , Marth Christian 
Published: December 2008

AbstractIRF‐1 and IRF‐2 expression was determined by real‐time PCR in 138 ovarian cancer samples and 30 healthy ovarian biopsies and was correlated with the expression of other relevant immunologic parameters and common clinicopathologic variables. Regulation of IRF‐1 and IRF‐2 was evaluated by cytokine treatment of various ovarian cancer cell lines, human peritoneal mesothelial cells and ovarian surface epithelium. IRF‐1 but not IRF‐2 was constitutively over‐expressed in 5 of 7 ovarian cancer cell lines. Both IRFs were inducible with IFN‐γ and to a lesser extent with IL‐1 or TNF‐α, but not with IL‐6. Epidermal growth factor (EGF) treatment down‐regulated both IRFs. In ovarian cancer samples only IRF‐1, but not IRF‐2 mRNA, was up‐regulated when compared with healthy ovarian tissue. IRF‐1 but not IRF‐2 expression was significantly associated with interferon (IFN)‐γ and forkhead box P3 (FoxP3). In univariate survival analysis, strong expression of IRF‐1 and IRF‐2 predicted improved disease‐free survival (DFS) and overall survival (OS). In Cox regression analyses, IRF‐1 retained independent prognostic significance for DFS and OS and IFN‐γ for OS. In contrast to other solid tumors, IRF‐2 expression cannot be regarded as a classic oncoprotein associated with poor prognosis in ovarian cancer. Of the immunologic parameters investigated, intratumoral IRF‐1 expression is the most powerful independent predictor of a favorable clinical outcome. © 2008 Wiley‐Liss, Inc.
Long‐run purchasing power parity with asymmetric adjustment: evidence from nine major oil‐exporting countries
Authors: Chang Tsangyao , Liu Wen‐Chi 
Published: December 2008

AbstractIn this study, we apply threshold cointegration test advanced by Enders and Siklos (2001) to investigate the properties of asymmetric adjustment in long‐run purchasing power parity (PPP) in nine major oil‐exporting countries. Although there is evidence of long‐run PPP for these nine oil‐exporting countries, the adjustment mechanism is asymmetric. These results have important policy implications for these nine oil‐exporting countries under study. Copyright © 2008 John Wiley & Sons, Ltd.
Atypical presentations of thrombotic thrombocytopenic purpura: A review
Authors: Sarode Ravi 
Published: December 2008

AbstractThrombotic thrombocytopenic purpura (TTP) is diagnosed by the presence of microangiopathic hemolytic anemia and thrombocytopenia in a patient who frequently presents with central nervous system involvement and, to a lesser extent, renal dysfunction. Recent understanding of the pathophysiology of TTP due to severe deficiency of von Willebrand factor cleaving protease, known as ADAMTS13, has improved diagnosis of TTP. Once the diagnosis is suspected, life‐saving therapeutic plasma exchange therapy is initiated. Occasionally, an unusual clinical presentation makes TTP diagnosis difficult, thus resulting in a delay in the management of TTP. This review highlights a variety of atypical TTP presentations described in the literature. It is intended to bring unusual scenarios to the clinician's awareness, so that timely treatment can be delivered. J. Clin. Apheresis, 2009. © 2008 Wiley‐Liss, Inc.
Using participatory methods and geographic information systems (GIS) to prepare for an hiv community‐based trial in Vulindlela, South Africa (Project Accept–HPTN 043)
Authors: Chirowodza Admire , van Rooyen Heidi , Joseph Philip , Sikotoyi Sindisiwe , Richter Linda , Coates Thomas 
Published: December 2008

AbstractRecent attempts to integrate geographic information systems (GIS) and participatory techniques, have given rise to terminologies such as participatory GIS and community‐integrated GIS. Although GIS was initially developed for physical geographic application, it can be used for the management and analysis of health and health care data. Geographic information systems, combined with participatory methodology, have facilitated the analysis of access to health facilities and disease risk in different populations. Little has been published about the usefulness of combining participatory methodologies and GIS technology in an effort to understand and inform community‐based intervention studies, especially in the context of HIV. This article attempts to address this perceived gap in the literature. The authors describe the application of participatory research methods with GIS in the formative phase of a multisite community‐based social mobilization trial, using voluntary counseling and testing and post‐test support as the intervention. © 2008 Wiley Periodicals, Inc.
National benchmarking between the Nordic countries on the quality of care
Authors: Mainz Jan , Hjulsager Morten , og Mette Thorup Eriksen , Burgaard Jytte 
Published: December 2008

AbstractThis paper describes the Nordic Indicator Project that aims at describing and analysing the quality of care for important diseases in the Nordic countries (Denmark, Finland, Greenland, Iceland, Norway and Sweden). The Council of Ministers decided to appoint a working group for quality mapping with the aim of giving Nordic citizens, politicians, health workers and authorities the opportunity to evaluate and compare performance across the Nordic countries. The working group selected 36 prioritised quality indicators, including cancer indicators, for benchmarking between the Nordic countries. Additionally, 40 ‘potential indicators’ have been identified for future developments. This international projects document how difficult it is to do international benchmarking. The experience of the Nordic Council of Ministers Quality Project has shown that even for common indicators as survival and mortality rates for breast cancer, colorectal cancer and lung cancer etc., it is difficult to yield data that are representative to the international nations as a whole. It seems that modern health care systems are not able do document their quality. At national and international level we need to invest in quality measurement systems and in international collaboration. J. Surg. Oncol. 2009;99:505–507. © 2008 Wiley‐Liss, Inc.
A unique case of cortical myoclonus sensitive to visual stimuli in the peripersonal space
Authors: Parasivam Sharavanan , Cowey Max , Day Bruce , Thyagarajan Dominic 
Published: December 2008

AbstractMultimodal representation of peripersonal or near space has been demonstrated in the brain of the nonhuman primate through invasive electrophysiological experiments. Representation of peripersonal space in the human brain has been inferred from extinction experiments and functional imaging studies. We present a unique case of lower limb myoclonus in a patient with common variable immunodeficiency which is sensitive to visual stimuli in the peripersonal space and light touch. This case provides further evidence for near space representation in the human brain. We hypothesize that somatopically organized multimodal areas exist in the human brain which code for peripersonal space. © 2008 Movement Disorder Society
Hispanic charitable giving: An opportunity for nonprofit development
Authors: Marx Jerry D. , Carter Vernon Brooks 
Published: December 2008

AbstractIn 2003, the U.S. Census Bureau indicated that Hispanics had become the largest U.S. minority group. Representing 14 percent of the population, more than forty million Hispanics currently live in the United States and are a growing source of charitable giving. This study uses a national probability sample (n = 3,261) to examine variables that may influence Hispanic charitable giving in the United States to private nonprofit organizations. Logistic regression analyses indicated that Hispanics were eight times more likely to donate to human service organizations when using payroll deduction. In addition, Hispanics who were solicited for a donation by telephone were twice as likely to make a donation to educational organizations as Hispanic donors not solicited by phone. Volunteerism was also a predictor of Hispanic charitable giving. U.S. demographic trends and this study's findings suggest that nonprofit leaders, including those responsible for fundraising in private nonprofit organizations, need to be aware of the opportunities for Hispanic charitable support.
Effects of vinyltrimethoxy silane on mechanical properties and morphology of polypropylene‐woodflour composites
Authors: Bouza Rebeca , Abad María José , Barral Luis , Ladra Marcelino 
Published: December 2008

AbstractThe effects of composition and interface modification on the tensile properties and the impact resistance of different woodflour/polypropylene composites (WPC) were studied. The woodflour was treated with vinyltrimethoxy silane as a coupling agent, and its effect on the WPC properties was examined. In addition, the tensile data were fitted with several semiempirical models to clarify the mechanical behavior of the composites. The Pukánszky parameters obtained from the fit of the tensile strength data revealed that the distribution of the filler was more homogeneous in the composites containing silane and that interaction between components was improved. The impact strength was maximal for the composites containing 30% of silane‐treated woodflour. Morphological analysis by SEM revealed that the woodflour tended to form agglomerates when present in relatively high amounts in the formulations. For the silane‐treated composites, the dispersion of the filler into the polypropylene (PP) matrix improved, although surface treatment blocked the inclusion of PP into the wood cells. This probably decreased the elastic moduli, even when the filler‐matrix interaction was improved. The beneficial effects of the coupling agent on the WPC properties were greater in the materials containing a relatively low amount of filler (up to 30%); the effectiveness of 0.5% and 1% organosilane were very similar, demonstrating the effectiveness of the coupling agent. POLYM. ENG. SCI., 2009. © 2008 Society of Plastics Engineers
Graft polymerization of N‐tert‐butylacrylamide onto polypropylene during melt extrusion and biocidal properties of its products
Authors: Badrossamay Mohammad Reza , Sun Gang 
Published: December 2008

AbstractFunctionalization of polypropylene (PP) by radical graft polymerization with N‐tert‐butylacrylamide (NTBA) was successfully conducted during melt extrusion, and the grafted products were employed as precursors of biocidal N‐halamine polymers. Graft polymerization conditions, including monomer and initiator concentrations, addition of a comonomer styrene (St), were studied. Fourier transformed spectroscopy (FTIR) results and nitrogen analysis confirmed the graft polymerization on PP backbone during the reactive extrusion. The results also indicated that increase in initiator concentration led to more PP chain scission and reduction in mixing torque or polymer chain length. As the monomer concentration rose, grafted monomer content in the products improved, revealing increased grafting copolymerization in the system. Addition of St as a comonomer adversely affected grafting of NTBA, but significantly prevented polymer chain scission. This may be due to lower tendency of NTBA for copolymerization. The halogenated products exhibited potent antimicrobial properties against Escherichia coli, and the antimicrobial properties were durable and regenerable. POLYM. ENG. SCI., 2009. © 2008 Society of Plastics Engineers
Evaluation of stimulus preference assessment methods with general education students
Authors: Schanding G. Thomas , Tingstrom Daniel H. , Sterling‐Turner Heather E. 
Published: December 2008

AbstractThe current exploratory study examined the ability of three stimulus preference assessments to identify effective reinforcers for general education students. Four students from Grades K through 5 and their teachers participated. A student nomination, teacher nomination, and ongoing (daily) stimulus preference assessment were evaluated. The results demonstrate that reinforcers identified by both general education students and their teachers increased behavior similarly, although correspondence between teacher‐ and student‐selected items themselves were low. Evaluation of the procedures indicated the highest rate of responding occurred under the ongoing reinforcer assessment condition for 3 of the 4 students. Limitations and future research are discussed. © 2008 Wiley Periodicals, Inc.
Fibril aggregation inhibitory activity of the β‐sheet breaker peptides: a molecular docking approach
Authors: Chini Maria Giovanna , Scrima Mario , D'Ursi Anna Maria , Bifulco Giuseppe 
Published: December 2008

AbstractIn the present study, we used a molecular docking as a rapid, interactive method to study the inhibition of fibrillogenesis process by β‐sheet breaker peptide (BSB) (Ac‐L1‐V2‐(NMet)F3‐F4‐A5‐NH2). Our aim was to find the complex (Aβ:BSB) that blocks the aggregation of the fibrils, and to identify the binding sequences for the small peptides on Aβ1–42. An NMR structure solved by Lührs et al. in 2005 was used to study the interaction of BSB with the amyloid aggregated forms. From our preliminary step‐by‐step docking studies, the L(17)‐D(23) sequence seems to be one of the most common active sites of Aβ1–42, and critical in amyloid fibril formation. We note that a single molecule of BSB does not influence the interaction between the two fibrils, while a little excess of BSB (two molecules) with respect to the amyloid does not completely block but undoubtedly obstructs the aggregation process. Copyright © 2008 European Peptide Society and John Wiley & Sons, Ltd.