bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reward-related processing in the human brain: Developmental considerations
Authors: Fareri Dominic S. , Martin Laura N. , Delgado Mauricio R. 
Published: October 2008

AbstractThe pursuit of rewarding experiences motivates everyday human behavior, and can prove beneficial when pleasurable, positive consequences result (e.g., satisfying hunger, earning a paycheck). However, reward seeking may also be maladaptive and lead to risky decisions with potentially negative long-term consequences (e.g., unprotected sex, drug use). Such risky decision making is often observed during adolescence, a time in which important structural and functional refinements occur in the brain's reward circuitry. Although much of the brain develops before adolescence, critical centers for goal-directed behavior, such as frontal corticobasal ganglia networks, continue to mature. These ongoing changes may underlie the increases in risk-taking behavior often observed during adolescence. Further, typical development of these circuits is vital to our ability to make well-informed decisions; atypical development of the human reward circuitry can have severe implications, as is the case in certain clinical and developmental conditions (e.g., attention-deficit/hyperactivity disorder). This review focuses on current research probing the neural correlates of reward-related processing across human development supporting the current research hypothesis that immature or atypical corticostriatal circuitry may underlie maladaptive behaviors observed in adolescence.
Developmental changes and individual differences in risk and perspective taking in adolescence
Authors: Crone Eveline A. , Bullens L. , van der Plas E. A. A. , Kijkuit E. J. , Zelazo P. D. 
Published: October 2008

AbstractDespite the assumed prevalence of risk-taking behavior in adolescence, the laboratory evidence of risk taking remains scarce, and the individual variation poorly understood. Drawing from neuroscience studies, we tested whether risk and reward orientation are influenced by the perspective that adolescents take when making risky decisions. Perspective taking was manipulated by cuing participants prior to each choice whether the decision was made for “self,” or from the perspective of an “other” (the experimenter in Experiment 1; a hypothetical peer in Experiment 2). In Experiment 1, we show a developmental decrease in risk-taking behavior across different stages of adolescence. In addition, all age groups made fewer risky choices for the experimenter, but the difference between self and other was larger in early adolescence. In Experiment 2, we show that high sensation-seeking (SS) adolescents make more risky choices than low SS adolescents, but both groups make a similar differentiation for other individuals (low risk-taking or high risk-taking peers). Together, the results show that younger adolescents and high SS adolescents make more risky choices for themselves, but can appreciate that others may make fewer risky choices. The developmental change toward more rational decisions versus emotional, impulsive decisions may reflect, in part, more efficient integration of others’ perspectives into one's decision making. These developmental results are discussed regarding brain systems important for risk taking and perspective taking.
The development of emotion-related neural circuitry in health and psychopathology
Authors: Monk Christopher S. 
Published: October 2008

AbstractDisturbances in the detection of, response to, and interpretation of emotion are common in many forms of psychopathology. The amygdala, striatum, and structures within the prefrontal cortex are highly involved in mediating these stages of emotion processing, and evidence indicates that these regions show structural and functional alterations in different types of psychopathology, including anxiety, depression, and autism spectrum disorders. However, we do not know how genes and the environment interact to alter development of these brain regions in ways that give rise to emotion-related psychopathology. This review discusses the current understanding of brain regions that are involved in emotional functioning, how they develop, and how they are altered in three forms of psychopathology: anxiety, depression, and autism spectrum disorders. Following this, a framework is described that may facilitate the integration of investigations of genetic variation and brain function with symptom and diagnostic measures. The framework involves three components: (a) a greater emphasis on simultaneously analyzing multiple levels (genes, brain function, behavior, symptoms, and diagnoses); (b) further integration of developmental considerations, including timing of environmental events, adaptations (or maladaptations), and disorder-related trajectories that guide some children toward atypical experiences; and (c) greater cross-talk between animal and human investigations to take advantage of biological measures that cannot be acquired in humans.
The role of the amygdala in bipolar disorder development
Authors: Garrett Amy , Chang Kiki 
Published: October 2008

AbstractThe amygdala has received great interest as a possible neurophysiological substrate of bipolar disorder (BD). This review summarizes information about the structure and function of the amygdala with attention to its role in experienced emotion and mood. We review the evidence for amygdala pathology in psychiatric conditions and discuss the role of the amygdala in BD during development. There appear to be consistent findings in the neuroimaging literature that suggest an etiological model for BD that involves abnormalities in the structure and function of the amygdala, but also depends on the failure of prefrontal cortical regions to modulate amygdala activity. In addition, evidence is accumulating to suggest that this model has flexible outcomes, depending on factors intrinsic and extrinsic to BD, and may follow several possible paths across the course of maturational development.
Developmental disruptions in neural connectivity in the pathophysiology of schizophrenia
Authors: Karlsgodt Katherine H. , Sun Daqiang , Jimenez Amy M. , Lutkenhoff Evan S. , Willhite Rachael , van Erp Theo G. M. , Cannon Tyrone D. 
Published: October 2008

AbstractSchizophrenia has been thought of as a disorder of reduced functional and structural connectivity. Recent advances in neuroimaging techniques such as functional magnetic resonance imaging, structural magnetic resonance imaging, diffusion tensor imaging, and small animal imaging have advanced our ability to investigate this hypothesis. Moreover, the power of longitudinal designs possible with these noninvasive techniques enable the study of not just how connectivity is disrupted in schizophrenia, but when this disruption emerges during development. This article reviews genetic and neurodevelopmental influences on structural and functional connectivity in human populations with or at risk for schizophrenia and in animal models of the disorder. We conclude that the weight of evidence across these diverse lines of inquiry points to a developmental disruption of neural connectivity in schizophrenia and that this disrupted connectivity likely involves susceptibility genes that affect processes involved in establishing intra- and interregional connectivity.
Paying attention to reading: The neurobiology of reading and dyslexia
Authors: Shaywitz Sally E. , Shaywitz Bennett A. 
Published: October 2008

AbstractExtraordinary progress in functional brain imaging, primarily advances in functional magnetic resonance imaging, now allows scientists to understand the neural systems serving reading and how these systems differ in dyslexic readers. Scientists now speak of the neural signature of dyslexia, a singular achievement that for the first time has made what was previously a hidden disability, now visible. Paralleling this achievement in understanding the neurobiology of dyslexia, progress in the identification and treatment of dyslexia now offers the hope of identifying children at risk for dyslexia at a very young age and providing evidence-based, effective interventions. Despite these advances, for many dyslexic readers, becoming a skilled, automatic reader remains elusive, in great part because though children with dyslexia can be taught to decode words, teaching children to read fluently and automatically represents the next frontier in research on dyslexia. We suggest that to break through this “fluency” barrier, investigators will need to reexamine the more than 20-year-old central dogma in reading research: the generation of the phonological code from print is modular, that is, automatic and not attention demanding, and not requiring any other cognitive process. Recent findings now present a competing view: other cognitive processes are involved in reading, particularly attentional mechanisms, and that disruption of these attentional mechanisms play a causal role in reading difficulties. Recognition of the role of attentional mechanisms in reading now offer potentially new strategies for interventions in dyslexia. In particular, the use of pharmacotherapeutic agents affecting attentional mechanisms not only may provide a window into the neurochemical mechanisms underlying dyslexia but also may offer a potential adjunct treatment for teaching dyslexic readers to read fluently and automatically. Preliminary studies suggest that agents traditionally used to treat disorders of attention, particularly attention-deficit/hyperactivity disorder, may prove to be an effective adjunct to improving reading in dyslexic students.
Longitudinal association between infant disorganized attachment and childhood posttraumatic stress symptoms
Authors: Macdonald Helen Z. , Beeghly Marjorie , Grant-Knight Wanda , Augustyn Marilyn , Woods Ryan W. , Cabral Howard , Rose-Jacobs Ruth , Saxe Glenn N. , Frank Deborah A. 
Published: October 2008

AbstractThe purpose of this study was to evaluate whether children with a history of disorganized attachment in infancy were more likely than children without a history of disorganized attachment to exhibit symptoms of posttraumatic stress disorder (PTSD) at school age following trauma exposure. The sample consisted of 78 8.5-year-old children from a larger, ongoing prospective study evaluating the effects of intrauterine cocaine exposure (IUCE) on children's growth and development from birth to adolescence. At the 12-month visit, children's attachment status was scored from videotapes of infant–caregiver dyads in Ainsworth's strange situation. At the 8.5-year visit, children were administered the Violence Exposure Scale—Revised, a child-report trauma exposure inventory, and the Diagnostic Interview for Children and Adolescents by an experienced clinical psychologist masked to children's attachment status and IUCE status. Sixteen of the 78 children (21%) were classified as insecure–disorganized/insecure–other at 12 months. Poisson regressions covarying IUCE, gender, and continuity of maternal care indicated that disorganized attachment status at 12 months, compared with nondisorganized attachment status, significantly predicted both higher avoidance cluster PTSD symptoms and higher reexperiencing cluster PTSD symptoms. These findings suggest that the quality of early dyadic relationships may be linked to differences in children's later development of posttraumatic stress symptoms following a traumatic event.
Echocardiographic and morphological evaluation of the right heart after closure of atrial septal defects
Authors: Sun Pin , Wang Zhi-Bin , Xu Chuan-Jin , Yang Su-Min , Jiang Lei 
Published: October 2008

AbstractObjectiveTo evaluate echocardiographically the function and morphology of the right heart subsequent to transcatheter closure of atrial septal defects.MethodsWe performed echocardiographic studies in 73 patients undergoing transcatheter closure of atrial septal defects 1 day prior to closure, and then 3 days and 3 months after closure. We calculated the antero-posterior diameter of the right ventricle, the transverse diameter and length of the right atrium, the pulmonary arterial pressure, and the velocities of systolic movement and early and late diastolic movement of the basal parietal walls of the right ventricle.ResultsThe atrial septal defects varied in size between 8 and 33 millimetres, and were closed using occluders measuring from 10 to 40 millimetres. At 3 days after closure, the antero-posterior diameter of the right ventricle, the transverse diameter and length of the right atrium, the pulmonary arterial pressure, and the velocities of mural motion were all significantly decreased. After 3 months, the size of the right heart had more or less normalized.ConclusionsTranscatheter closure of atrial septal defects produces marked improvement in the function and geometry of the chambers of the right heart, reducing pulmonary arterial pressure as well as abolishing the interatrial shunt.
Food patterns and Mediterranean diet in western and eastern Mediterranean islands
Authors: Romaguera Dora , Bamia Christina , Pons Antoni , Tur Josep A , Trichopoulou Antonia 
Published: October 2008

AbstractObjectiveTo assess current Mediterranean dietary patterns (MDP) in the western and eastern Mediterranean, i.e. in Balearic islanders (BI) and Greek islanders (GI).Subjects and methodsDietary patterns were assessed using FFQ on a representative sample (n1200) of the BI and GI (n1324) adult population. A Mediterranean Diet Score (MDS) was calculated according to the consumption of nine MDP components: (i) with a beneficial effect on health, i.e. vegetables, fruits and nuts, cereals, legumes, fish and shellfish, MUFA:SFA ratio, and moderate alcohol consumption; and (ii) with a detrimental effect on health, i.e. meat and meat products, and milk and dairy products. Persons with consumption of beneficial components below the median (GI plus BI) received a value of 0 and those with consumption above the median a value of 1. Persons with below-median consumption of detrimental components received a value of 1 and above-median consumption a value of 0. For alcohol, a value of 1 was given to consumptions of 10–50 g/d (men) and 5–25 g/d (women). The range of the MDS was 0–9, with higher scores indicating greater adherence to the MDP.ResultsGI showed higher adherence (mean MDS 5·12 (sd1·42)) to the MDP than BI (mean MDS 3·32 (sd1·23)). BI diet was characterized by a high intake of legumes, nuts, seed oils, sugar and confectionery, and non-alcoholic beverages compared with GI, whereas GI diet was richer in fruit, vegetables, potatoes, olive oil, animal products and alcoholic beverages.ConclusionsThe GI diet seems closer to the traditional MDP than the BI diet.
Impact of targeted food supplementation on pregnancy weight gain and birth weight in rural Bangladesh: an assessment of the Bangladesh Integrated Nutrition Program (BINP)
Authors: Nahar Shamsun , Mascie-Taylor CG Nicholas , Begum Housne Ara 
Published: October 2008

AbstractObjectivesTo assess whether the Bangladesh Integrated Nutrition Programme (BINP) correctly identified which pregnant women should be enrolled in the food supplementation programme, whether supplementation commenced on time and was taken on a regular basis. A second objective was to determine whether food supplementation led to enhanced pregnancy weight gain and reduction in the prevalence of low birth weight.DesignA one-year community-based longitudinal study.SettingA rural union of Bhaluka Upazila, Mymensingh, located 110 km north-west of Dhaka City, the capital of Bangladesh.ParticipantsA total of 1104 normotensive, non-smoking pregnant women who attended Community Nutrition Centres were studied from first presentation at the centre until child delivery.ResultsPregnant women who had a BMI of <18·5 kg/m2on first presentation should have been selected for supplementary feeding (2512 kJ (600 kcal)/d for six days per week) starting at month 4 (16 weeks) of pregnancy. However, of the 526 women who had BMI < 18·5 kg/m2, only 335 received supplementation; so the failure rate was 36·3 %. In addition, of those receiving supplementation, only 193 women (36·7 % of 526 women) commenced supplementation at the correct time, of whom thirty-two (9·6 % of 335 women) received supplementation for the correct number of days (100 % days). There were no significant differences in mean weight gain between BMI < 18·5 kg/m2supplemented or non-supplemented groups or between the equivalent groups with BMI ≥ 18·5 kg/m2. Weight gain was inversely related to initial weight, so lighter women gained relatively more weight during their pregnancy than heavier women. The mean birth weight in the supplemented and non-supplemented groups was 2·63 kg and 2·72 kg, respectively. Mothers with BMI < 18·5 kg/m2who were or were not supplemented had almost equal percentages of low-birth-weight babies (21 % and 22 %, respectively).ConclusionThe study raises doubt about the efficiency of the BINP to correctly target food supplementation to pregnant women. It also shows that food supplementation does not lead to enhanced pregnancy weight gain nor does it provide any evidence of a reduction in prevalence of low birth weight.
Increasing dietary fish intake has contributed to decreasing mortality from CHD among the older population in Hong Kong
Authors: Zhang Xin-Hua , Woo Jean , Heller Richard F 
Published: October 2008

AbstractObjectiveTo test whether change in the frequency of fish intake at population level would affect the trends of death from CHD and how many CHD events could be prevented in Hong Kong, a population among those with the highest fish consumption and the lowest CHD mortality in the world.DesignTime trends analysis with data from repeated dietary surveys and death registration.SettingHong Kong SAR, People’s Republic of China.SubjectsA total of 3096 men and women aged 40–69 years who participated in territory-wide surveys in 1995 or 2003 were included in the analysis of changes in dietary fish intake; all adults aged 40–69 years in Hong Kong were included in the analysis of time trends of CHD mortality.ResultsOver the period, the frequency of fish intake increased and CHD mortality decreased significantly in the population age group of 50–69 years, while in the age group of 40–49 years little change in both fish intake and CHD mortality was observed. It was estimated that 240 CHD deaths (or 29 % of the total) were avoided among the population aged 40–69 years in 2003, as more than half of the population consumed fish every day in Hong Kong.ConclusionsThe time trend of CHD mortality was inversely related to the trend of fish intake. The frequency of fish intake may have a substantial impact on the population for the prevention of CHD deaths in Hong Kong.
Difference fields and descent in algebraic dynamics. II
Authors: Chatzidakis Zoé , Hrushovski Ehud 
Published: October 2008

AbstractThis second part of the paper strengthens the descent theory described in the first part to
rational maps and arbitrary base fields. We obtain in particular a decomposition of any difference field extension into a tower of finite, field-internal and one-based difference field extensions. This is needed in order to obtain the ‘dynamical Northcott’ Theorem 1.11 of Part I in sharp form.
Genericity, generosity, and tori
Authors: Cherlin Gregory 
Published: October 2008

AbstractWhile the classification project for the simple groups of finite Morley rank is unlikely to
produce a classification of the simple groups of finite Morley rank, the enterprise has already arrived at a considerably closer approximation to that ideal goal than could have been realistically anticipated, with a mix of results of several flavors, some classificatory and others more structural, which can be combined when the stars are suitably aligned to produce results at a level of generality which, in parallel areas of group theory, would normally require either some additional geometric structure, or an explicit classification. And Bruno Poizat is generally awesome, though sometimes he goes too far.
Expansions of fields by angular functions
Authors: Evans David M. 
Published: October 2008

AbstractThe notion of an angular function has been introduced by Zilber as one possible way of connecting non-commutative geometry with two ‘counterexamples’ from model theory: the non-classical Zariski curves of Hrushovski and Zilber, and Poizat's field with green points. This article discusses some questions of Zilber relating to existentially closed structures in the class of algebraically closed fields with an angular function.
Groupes géométriques de rang de Morley fini
Authors: Frécon Olivier 
Published: October 2008

AbstractWe consider a new subgroup In(G) in any group G of finite Morley rank. This definably characteristic subgroup is the smallest normal subgroup of G from which we can hope to build a geometry over the quotient group G/ In(G). We say that G is a geometric group if In(G) is trivial.This paper is a discussion of a conjecture which states that every geometric group G of finite Morley rank is definably linear over a ring K1 ⊕…⊕ Kn where K1,…,Kn are some interpretable fields. This linearity conjecture seems to generalize the Cherlin–Zil'ber conjecture in a very large class of groups of finite Morley rank.We show that, if this linearity conjecture is true, then there is a Rosenlicht theorem for groups of finite Morley rank, in the sense that the quotient group of any connected group of finite Morley rank by its hypercentre is definably linear.
On types of CB-rank 1 in simple theories
Authors: Pillay Anand 
Published: October 2008

AbstractWe prove that if M0 is a model of a simple theory, and p(x) is a complete type of Cantor–Bendixon rank 1 over M0, then p is stationary and regular. As a consequence we obtain another proof that any countable model M0 of a countable complete simple theory T has infinitely many countable elementary extensions up to M0-isomorphism. The latter extends earlier results of the author in the stable case, and is a special case of a recent result of Tanovic.
Difference fields and descent in algebraic dynamics. I
Authors: Chatzidakis Zoé , Hrushovski Ehud 
Published: October 2008

AbstractWe draw a connection between the model-theoretic notions of modularity (or one-basedness), orthogonality and internality, as applied to difference fields, and questions of descent in in algebraic dynamics. In particular we prove in any dimension a strong dynamical version of Northcott's theorem for function fields, answering a question of Szpiro and Tucker and generalizing a theorem of Baker's for the projective line.The paper comes in three parts. This first part contains an exposition some of the main results of the model theory of difference fields, and their immediate connection to questions of descent in algebraic dynamics. We present the model-theoretic notion of internality in a context that does not require a universal domain with quantifier-elimination. We also note a version of canonical heights that applies well beyond polarized algebraic dynamics. Part II sharpens the structure theory to arbitrary base fields and constructible maps where in part I we emphasize finite base change and correspondences. Part III will include precise structure theorems related to the Galois theory considered here, and will enable a sharpening of the descent results for non-modular dynamics.