bluuebunny/crossref_metadata_2025_split huggingface dataset:
Submillimeter isotropic resolution carotid wall MRI with swallowing compensation: Imaging results and semiautomated wall morphometry
Authors: Koktzoglou Ioannis , Li Debiao 
Published: March 2007

AbstractPurposeTo assess a swallowing‐compensated, three‐dimensional (3D) diffusion‐prepared segmented steady‐state free precession (3D Nav‐D‐SSFP) technique for carotid wall MRI with 0.6‐mm isotropic spatial resolution, and its utility for semiautomated carotid wall morphometry.Materials and MethodsThe carotid arteries of seven healthy volunteers (N = 14) were imaged with 3D Nav‐D‐SSFP and black‐blood T2‐weighted (T2w) two‐dimensional (2D) fast spin‐echo (FSE). Carotid wall‐lumen contrast‐to‐noise ratio (CNR) was measured with both sequences. Measurement of carotid wall area (WA) and lumen area (LA) made in a semiautomated manner off of the 3D Nav‐D‐SSFP images were compared to those made manually.ResultsAdjusted for voxel volume and number of slices, a near six‐fold improvement in CNR per unit time was achieved with 3D Nav‐D‐SSFP relative to 2D T2w FSE (P < 0.001). Manual and semiautomated measurements of carotid WA and LA on the 3D Nav‐D‐SSFP images were highly correlated (intraclass correlation coefficient (ICC) = 0.961 and 0.996, respectively; P < 0.001).Conclusion3D Nav‐D‐SSFP is a time‐efficient, swallowing‐compensated, black‐blood technique that lends itself for semiautomated measurements of carotid WA and LA that are in good agreement with manual measurements. J. Magn. Reson. Imaging 2007. © 2007 Wiley‐Liss, Inc.
A dendrimer‐based nanosized contrast agent dual‐labeled for magnetic resonance and optical fluorescence imaging to localize the sentinel lymph node in mice
Authors: Koyama Yoshinori , Talanov Vladimir S. , Bernardo Marcelino , Hama Yukihiro , Regino Celeste A.S. , Brechbiel Martin W. , Choyke Peter L. , Kobayashi Hisataka 
Published: March 2007

AbstractPurposeTo preoperatively and intraoperatively localize the sentinel lymph node (SLN), a single hybrid probe for MR and near infrared (NIR) optical imaging was synthesized and tested.Materials and MethodsA macromolecular MR/NIR optical contrast agent was synthesized based on a ∼191 gadolinium‐labeled contrast agent using generation‐6 polyamidoamine dendrimer (G6), which is also labeled with 2 Cy5.5, an NIR fluorophore. After establishing the optimal dose, the agent was injected into mammary glands of 10 normal mice to examine the lymphatic drainage from the breast using a 3T clinical scanner. Immediately after the MRI scan, NIR optical imaging and image‐guided surgery were performed to compare the two imaging modalities.ResultsTo consistently identify the SLNs, we needed to inject 25 μL of 30 mM [Gd] G6‐Cy5.5. All SLNs could be easily identified and resected under NIR optical imaging‐guided surgery. Although external NIR optical imaging failed to identify SLNs close to the injection site due to shinethrough, MR lymphography (MRL) consistently identified all SLNs regardless of their location.ConclusionWe have successfully synthesized and tested a dual labeled MR/NIR optical hybrid contrast agent, G6‐Cy5.5 for reoperative and intraoperative localization of SLNs. J. Magn. Reson. Imaging 2007. © 2007 Wiley‐Liss, Inc.
Time‐resolved 3D MR velocity mapping at 3T: Improved navigator‐gated assessment of vascular anatomy and blood flow
Authors: Markl Michael , Harloff Andreas , Bley Thorsten A. , Zaitsev Maxim , Jung Bernd , Weigang Ernst , Langer Mathias , Hennig Jürgen , Frydrychowicz Alex 
Published: March 2007

AbstractPurposeTo evaluate an improved image acquisition and data‐processing strategy for assessing aortic vascular geometry and 3D blood flow at 3T.Materials and MethodsIn a study with five normal volunteers and seven patients with known aortic pathology, prospectively ECG‐gated cine three‐dimensional (3D) MR velocity mapping with improved navigator gating, real‐time adaptive k‐space ordering and dynamic adjustment of the navigator acceptance criteria was performed. In addition to morphological information and three‐directional blood flow velocities, phase‐contrast (PC)‐MRA images were derived from the same data set, which permitted 3D isosurface rendering of vascular boundaries in combination with visualization of blood‐flow patterns.ResultsAnalysis of navigator performance and image quality revealed improved scan efficiencies of 63.6% ± 10.5% and temporal resolution (<50 msec) compared to previous implementations. Semiquantitative evaluation of image quality by three independent observers demonstrated excellent general image appearance with moderate blurring and minor ghosting artifacts. Results from volunteer and patient examinations illustrate the potential of the improved image acquisition and data‐processing strategy for identifying normal and pathological blood‐flow characteristics.ConclusionNavigator‐gated time‐resolved 3D MR velocity mapping at 3T in combination with advanced data processing is a powerful tool for performing detailed assessments of global and local blood‐flow characteristics in the aorta to describe or exclude vascular alterations. J. Magn. Reson. Imaging 2007. © 2007 Wiley‐Liss, Inc.
Time‐resolved, high‐resolution contrast‐enhanced MR angiography of dialysis shunts using the CENTRA keyhole technique with parallel imaging
Authors: Mende Katja A. , Froehlich Johannes M. , von Weymarn Constantin , Hoogeveen Romhild , Kistler Thomas , Zollikofer Christoph L. , Wentz Klaus U. 
Published: March 2007

AbstractPurposeTo evaluate the use of a dynamic keyhole magnetic resonance angiography (MRA) sequence combined with sensitivity encoding (SENSE) for hemodialysis shunts, because surveillance with conventional contrast‐enhanced MRA (CE‐MRA) is limited by its low temporal resolution, resulting in arteriovenous overlay.Materials and MethodsA total of 12 patients with Brescia‐Cimino shunts were investigated prospectively using the new technique. During the contrast passage (gadoterate, Gd‐DOTA) a series of five to nine dynamic central k‐space measurements (10% for upper‐arm shunt, 25% for lower‐arm shunt) followed by a full reference data set were acquired. The outer k‐space data of the single reference scan were used to complete the dynamic data sets.ResultsAll studies were diagnostic (17 stenoses, three aneurysms) without complications. The acquisition times for a single dynamic scan of the upper‐ and lower‐arm shunts were 2.2 and 3.2 seconds, respectively, while the reference scan needed 13 and 22.4 seconds, respectively. The dynamic angiograms allowed the differentiation of arterial and venous filling despite a mean peak delay time of only 4.2 seconds in the shoulder region. Image quality qualified in consensus by two experienced readers was rated “good” in 19 cases and “intermediate” in five cases with high mean values for signal‐to‐noise ratios (SNRs) and contrast‐to‐noise‐ratios (CNRs).ConclusionWe have successfully implemented a fast, dynamic, CE‐MRA technique with CE timing robust angiography (CENTRA) keyhole and SENSE in clinical routine. High spatial and temporal resolution improve the diagnostics of dialysis shunts and allow the assessment of detailed, dynamic, four‐dimensional (4D) information. J. Magn. Reson. Imaging 2007. © 2007 Wiley‐Liss, Inc.
Interaction between rod and cone inputs in mixed‐input bipolar cells in goldfish retina
Authors: Joselevitch Christina , Kamermans Maarten 
Published: March 2007

AbstractOne class of goldfish bipolar cells, the mixed‐input bipolar cell, contacts both rods and cones. Although the morphology of the different mixed‐input bipolar cell subtypes has been described, insight into the interaction between rods and cones at the bipolar cell level is scarce. The aim of this study was to characterize this interaction in the different physiological types of mixed‐input bipolar cells. We found mixed‐input bipolar cells that depolarized, hyperpolarized, or showed a combination of the two types of response after center stimulation. The relative contributions of rod and cone inputs varied strongly in these cell populations. Depolarizing mixed‐input bipolar cells are rod‐dominated, having the highest sensitivity and the smallest dynamic range. Hyperpolarizing mixed‐input bipolar cells, on the other hand, have a more balanced rod‐cone input ratio. This extends their dynamic range and decreases their sensitivity. Finally, opponent mixed‐input bipolar cells seem to be mostly cone‐dominated, although some rod input is present. The antagonistic photoreceptor inputs form a push‐pull system that makes these mixed‐input bipolar cells very sensitive to changes in light intensity. Our finding that spectral tuning changes with light intensity conflicts with the idea that the separate nonopponent and opponent channels are related to coding of brightness and color, respectively. The organization of mixed‐input bipolar cells into various classes with different dynamic ranges and absolute sensitivities might be a strategy to transmit information about all visual aspects most efficiently, given the sustained nature of bipolar cell responses and their limited voltage range. © 2007 Wiley‐Liss, Inc.
Prognostic value of tumor thickness in patients with merkel cell carcinoma
Authors: Goldberg Stephanie R. , Neifeld James P. , Frable William J. 
Published: March 2007

AbstractBackground and ObjectivesMerkel cell carcinoma is an aggressive skin malignancy that often presents with tumor metastases. We hypothesized that tumor thickness might correlate with both regional and metastatic tumor spread and could, therefore, be used as an independent prognostic variable. The purpose of this study was to see if depth of tumor invasion would predict prognosis independent of tumor stage.MethodsData pertaining to clinical presentation, pathology, treatment, and survival were collected for patients diagnosed with Merkel cell carcinoma from 1972 to 2005. Patients were staged according to AJCC guidelines. Pathologic specimens were evaluated for tumor thickness. The relationship between tumor thickness and disease‐free survival or overall survival was analyzed using Kaplan–Meier survival analyses.ResultsSixty patients were identified. Five‐year disease‐free survivals for Stages 1, 2, and 3 patients were 20%, 33%, and 0%, respectively. Five‐year overall survivals for Stages 1, 2, and 3 patients were 33.3%, 60%, and 16.7%, respectively. There was no correlation between tumor thickness and either disease‐free survival or overall survival.ConclusionsThis study suggests that tumor thickness is not an independent risk factor for survival. Mean tumor thickness did increase with the AJCC stages, but this most likely represents more advanced stage of disease. J. Surg. Oncol. 2007;95:618–622. © 2007 Wiley‐Liss, Inc.
Barriers to rehabilitation of patients with extremity sarcomas
Authors: Custodio Christian M. 
Published: March 2007

AbstractThe treatment of most extremity bone or soft tissue sarcomas involves either limb salvage surgery with adjuvant chemoradiation therapy or amputation. The rehabilitation of patients with extremity sarcomas is challenging, and the approach differs depending on the choice of surgical procedure as well as potential‐associated medical complications. Early, interdisciplinary rehabilitation involvement is helpful in lessening the impact of expected impairments and disability. There is a lack of evidence examining specific rehabilitation interventions in this patient population. Functional outcomes and quality of life studies suggest overall similar findings between limb salvage patients and amputees, but with differences in various subscales. Rehabilitation interventions are therefore individualized; based on the assessment of medical limitations, functional goals and expectations, and modification of environmental factors. Overcoming medical and oncologic barriers to rehabilitation; as well as psychological, structural, cultural, political, and economic barriers; can serve to lessen the degree of disability. J. Surg. Oncol. 95:393–399. © 2007 Wiley‐Liss, Inc.
Serum insulin‐like growth factor I/free prostate specific antigen (IGF‐I/fPSA) ratio enhances prostate cancer detection in men with total PSA 4.0–10.0 ng/ml
Authors: Zhigang Zhao , Jieming Liu , Su Li , Wenlu Shen 
Published: March 2007

AbstractBackgroundRecent studies have suggested that IGF‐I and IGFBP‐3, in combination with PSA, may enhance PCa detection. This study was to investigate the use of serum IGF‐I and IGFBP‐3, and their combinations with prostate volume and fPSA in enhancing the discriminatory diagnosis of PCa in men with tPSA of 4.0–10.0 ng/ml.MethodsSerum IGF‐I and IGFBP‐3 were determined by ELISA from 586 men with tPSA between 4.0 and 10.0 ng/ml. Of them, 281 were diagnosed with PCa and 305 without. ROC, univariate and multivariate logistic regression analyses were performed to evaluate the predictive performance of those parameters.ResultsIGF‐I, IGFD, IGF‐I/fPSA, and IGFBP‐3/fPSA were significantly higher in PCa cases than benign controls, whereas the differences of IGFBP‐3 and IGFBPD were statistically insignificant between the two groups, respectively. The AUC values indicated enhanced performance of IGF‐I/fPSA ratio (AUC = 0.753) in PCa detection compared with the currently used f/tPSA (AUC = 0.689). Multivariate logistic regression confirmed the observed relationships and identified IGF‐I/fPSA as independent factor in PCa presence.ConclusionOur data show that IGF‐I/fPSA as a promising marker can enhance PCa detection in ambiguous cases often found in the tPSA between 4.0 and 10.0 ng/ml. J. Surg. Oncol. 2007;96:54–61. © 2007 Wiley‐Liss, Inc.
Intergenerational transmission of trauma: Exploring mother–infant prenatal attachment
Authors: Schwerdtfeger Kami L. , Goff Briana S. Nelson 
Published: March 2007

AbstractEarly childhood attachment and bonding and the intergenerational transmission of trauma are two key areas to address to understand the connection between parental trauma and the parent–child relationship. The purpose of the current study was to explore the relationship between trauma and past parental attachment behaviors of 41 expectant mothers and the subsequent development of attachment and bonding with their unborn child. Results of the current study suggest that trauma history, in general, does not negatively impact expectant mothers' current prenatal attachment with their unborn child. However, interpersonal trauma history does appear to have negative effects on prenatal attachment. These results point to the importance of understanding the role of interpersonal trauma exposure on prenatal attachment.
The increasing internationalization of mainstream posttraumatic stress disorder research: A bibliometric study
Authors: Figueira Ivan , Luz Mariana da , Braga Raphael J. , Cabizuca Mariana , Coutinho Evandro , Mendlowicz Mauro V. 
Published: March 2007

AbstractThe aim of this study was to quantify changes in the national contributions to research related to posttraumatic stress disorder (PTSD) from 1983 through 2002. Using the Web of Science database (Thomson Scientific, Philadelphia, PA), we classified articles according to the year of publication and the country of the authors. The number of publishing countries increased from 7 between 1983 and 1987 to 39 between 1998 and 2002. Meanwhile, the U.S. output share declined from 87.6% in the first period to 62.4%. Although the number of countries publishing on PTSD has steadily increased, research is still dominated qualitatively and quantitatively by developed countries. These findings suggest a growing international acceptance of this diagnostic category. However, the immaturity of PTSD research is demonstrated by the concentration of publications in a few countries.
The consistency of combat exposure reporting and course of PTSD in Vietnam War veterans
Authors: Koenen K. C. , Stellman S. D. , Dohrenwend B. P. , Sommer J. F. , Stellman J. M. 
Published: March 2007

AbstractSelf‐reports of traumatic events are often used in clinical and epidemiologic studies. Nevertheless, research suggests combat exposure reports may be biased by posttraumatic stress disorder (PTSD) symptom severity, leading to an inflated dose‐response relation between combat exposure and PTSD. The authors examined the consistency in combat exposure reports and their relation to PTSD symptoms in Vietnam Veteran American Legionnaires who responded to two mailed surveys (1984, 1998; N = 1,462). Combat exposure reports were highly reliable (test–retest correlation = 0.87). However, changes in exposure reporting were related to changes in PTSD symptoms, specifically reexperiencing symptoms. The effect size of the dose‐response relation attributable to changes in reporting was smaller for continuous than categorical measures. Findings are discussed in relation to recent controversies over veterans' combat exposure reports.
Intimate partner psychological aggression and child behavior problems
Authors: Clarke Stephanie B. , Koenen Karestan C. , Taft Casey T. , Street Amy E. , King Lynda A. , King Daniel W. 
Published: March 2007

AbstractThe present study examined the relationship between intimate partner psychological aggression and children's behavior problems in a community sample of families (N = 470 children). The results showed that psychological aggression experienced by the mother has adverse effects on children's externalizing and internalizing behavior problems over and above the effects of physical aggression. The association between psychological aggression and child behavior problems was partially mediated by maternal distress. Exposure to psychological aggression appears to have unique direct and indirect adverse effects on children.
Kinetic studies on the reactions of 3‐isothiazolones with 2‐methyl‐2‐propanethiol
Authors: Morley John O. , Kapur A. Jayne Oliver , Charlton Michael H. 
Published: March 2007

AbstractThe kinetics of the ring‐opening reactions of the 3‐isothiazolones (1a–d) with aqueous 2‐methyl‐2‐propanethiol has been explored at pH 4. The results strongly suggest that the reaction is second order in thiol and third order overall. Extrapolation of the kinetic data gives third‐order rate constants that lie in the order (1a) > (1b) > (1c) > (1d) in line with the known biological activity of these derivatives. The mechanism of the reaction is thought to involve attack by one thiol at the sulfur atom of the isothiazolone with the concomitant hydrogen bonding of a second thiol to the amide nitrogen. Calculations of the structure and electronic properties of the isothiazolones at the RHF 6‐31G** level are supportive. © 2007 Wiley Periodicals, Inc. Int J Chem Kinet 39: 254–260, 2005
Homogeneous, unimolecular gas‐phase elimination kinetics of ethyl esters of glyoxylic, 2‐oxo‐propanoic, and 3‐methyl‐2‐oxo‐butanoic acids
Authors: Reyes Andreina , Dominguez Rosa M. , Tosta Maria , Herize Armando , Chuchani Gabriel 
Published: March 2007

AbstractThe rates of elimination of several ethyl esters of 2‐oxo‐carboxylic acid were determined in a seasoned static reaction vessel over the temperature range 350–430°C and pressure range 33–240 Torr. The reactions, in the presence of a free‐radical inhibitor, are homogeneous, unimolecular, and follow a first‐order rate law. The overall and partial rate coefficients are expressed by the Arrhenius equation.Ethyl glyoxalate

equation image
Ethyl 2‐oxo‐propionate

equation image
Ethyl 3‐methyl‐2‐oxo‐butyrate

equation image

The mechanisms of these elimination reactions are described in terms of concerted cyclic transition state structures. © 2007 Wiley Periodicals, Inc. Int J Chem Kinet 39: 268–275, 2007
Effect of medical and surgical interventions on health‐related quality of life in Parkinson's disease
Authors: Martinez‐Martin Pablo , Deuschl Günther 
Published: March 2007

AbstractMotor‐related parameters are the standard outcome parameters for treatment interventions. Nonetheless, subjective appraisals about the consequences of treatment on health‐related quality of life (HRQoL) are meanwhile established and may uncover important aspects of interventions. We have reviewed the literature with a defined search strategy and collected 61 clinical trials, which have used HRQoL as a planned outcome parameter. The articles were rated similarly as for the Task Force report of the Movement Disorder Society on interventions for Parkinson's disease (PD), but the relevant outcome parameter was HRQoL. We found that unilateral pallidotomy, deep brain stimulation of the subthalamic nucleus, and rasagiline are efficacious to improve the HRQoL of PD patients. For many other interventions, the efficacy to improve HRQoL in the PD setting cannot be considered to be proven so far. HRQoL should be part of future trial designs and more research is necessary to understand the determinants of QoL in PD. © 2007 Movement Disorder Society
Poroelastic model for pile–soil interaction in a half‐space porous medium due to seismic waves
Authors: Lu Jian‐Fei , Jeng Dong‐Sheng 
Published: March 2007

AbstractIn this paper, frequency domain dynamic response of a pile embedded in a half‐space porous medium and subjected to P, SV seismic waves is investigated. According to the fictitious pile methodology, the problem is decomposed into an extended poroelastic half‐space and a fictitious pile. The extended porous half‐space is described by Biot's theory, while the fictitious pile is treated as a bar and a beam and described by the conventional 1‐D structure vibration theory. Using the Hankel transformation method, the fundamental solutions for a half‐space porous medium subjected to a vertical or a horizontal circular patch load are established. Based on the obtained fundamental solutions and free wave fields, the second kind of Fredholm integral equations describing the vertical and the horizontal interaction between the pile and the poroelastic half‐space are established. Solution
of the integral equations yields the dynamic response of the pile to plane P, SV waves. Numerical results show the parameters of the porous medium, the pile and incident waves have direct influences on the dynamic response of the pile–half‐space system. Significant differences between conventional single‐phase elastic model and the poroelastic model for the surrounding medium of the pile are found. Copyright © 2007 John Wiley & Sons, Ltd.
Models and branch‐and‐cut algorithms for pickup and delivery problems with time windows
Authors: Ropke Stefan , Cordeau Jean‐François , Laporte Gilbert 
Published: March 2007

AbstractIn the pickup and delivery problem with time windows (PDPTW), capacitated vehicles must be routed to satisfy a set of transportation requests between given origins and destinations. In addition to capacity and time window constraints, vehicle routes must also satisfy pairing and precedence constraints on pickups and deliveries. This paper introduces two new formulations for the PDPTW and the closely related dial‐a‐ride problem (DARP) in which a limit is imposed on the elapsed time between the pickup and the delivery of a request. Several families of valid inequalities are introduced to strengthen these two formulations. These inequalities are used within branch‐and‐cut algorithms which have been tested on several instance sets for both the PDPTW and the DARP. Instances with up to eight vehicles and 96 requests (194 nodes) have been solved to optimality. © 2007 Wiley Periodicals, Inc. NETWORKS, Vol. 49(4), 258–272 2007
New planar chromatographic techniques in natural product analysis
Authors: Erdelmeier C. A. J. , Körig G. M. 
Published: March 2007

AbstractPlanar chromatography (PLC) is gaining importance in the analysis of natural products. Sophisticated instrumentation has become available in this field. Major progress in planar chromatography has been achieved through the development of forced‐flow techniques. Progress has also been made in the capillary‐controlled flow techniques with the use of modified development chambers. A large variety of stationary phases is available and strategies to optimize mobile phase compositions in PLC have been developed. The detection and quantitation in PLC has improved through direct coupling of PLC with spectroscopic methods with and the use of modern, computerized scanning densitometers.