bluuebunny/crossref_metadata_2025_split huggingface dataset:
Physical activity self-efficacy online intervention for adults with obesity: protocol for a feasibility study
Authors: Lee Seungmin , Lahoda Kevin , Myers Nicholas D. , Horowitz Andrew , Chiu Kenneth , Begdache Lina , Einav Eldad 
Published: February 2024

Abstract
Background
Even without weight loss, adults with obesity can greatly benefit from regular physical activity. The Physical Activity Self-efficacy (PAS) intervention is an online behavioral intervention newly developed to promote physical activity in adults with obesity by providing capability-enhancing learning opportunities. The objective of this manuscript is to describe the protocol for a feasibility study designed to investigate the feasibility and acceptability of implementing the PAS online intervention for adults with obesity recruited from a local weight management center in the United States of America (USA).

Methods
The study design is a prospective, double-blind, parallel-group individual randomized pilot trial. Thirty participants will be randomly assigned to the PAS group or usual care group to achieve a 1:1 group assignment. Recruitment of participants is scheduled to begin on 1 March 2024 at a local weight management center within a private healthcare system in the USA. There are six eligibility criteria for participation in this study (e.g., a body mass index ≥ 25.00 kg/m2). Eligibility verification and data collection will be conducted online. Three waves of data collection will take up to 14 weeks depending on participants’ progress in the study. The primary feasibility outcomes in the study will be: (a) participation rate, (b) engagement behavior, and (c) a preliminary effect size estimate for the effect of the PAS intervention on physical activity. Instruments designed to measure demographic information, anthropometric characteristics, self-efficacy, and acceptability will be included in the survey battery. A research-grade accelerometer will be used to measure free-living physical activity objectively. Data will be analyzed using descriptive statistics and inferential statistical models under an intention-to-treat approach.

Discussion
Results are intended to inform the preparation of a future definitive randomized controlled trial.

Trial registration
ClinicalTrials.gov, NCT05935111, registered 7 July 2023.
Neopentyl glycol-based radiohalogen-labeled amino acid derivatives for cancer radiotheranostics
Authors: Kaizuka Yuta , Suzuki Hiroyuki , Watabe Tadashi , Ooe Kazuhiro , Toyoshima Atsushi , Takahashi Kazuhiro , Sawada Koichi , Iimori Takashi , Masuda Yoshitada , Uno Takashi , Kannaka Kento , Uehara Tomoya 
Published: February 2024

Abstract
Background
L-type amino acid transporter 1 (LAT1) is overexpressed in various cancers; therefore, radiohalogen-labeled amino acid derivatives targeting LAT1 have emerged as promising candidates for cancer radiotheranostics. However, 211At-labeled amino acid derivatives exhibit instability against deastatination in vivo, making it challenging to use 211At for radiotherapy. In this study, radiohalogen-labeled amino acid derivatives with high dehalogenation stability were developed.

Results
We designed and synthesized new radiohalogen-labeled amino acid derivatives ([211At]At-NpGT, [125I]I-NpGT, and [18F]F-NpGT) in which L-tyrosine was introduced into the neopentyl glycol (NpG) structure. The radiolabeled amino acid derivatives were recognized as substrates of LAT1 in the in vitro studies using C6 glioma cells. In a biodistribution study using C6 glioma-bearing mice, these agents exhibited high stability against in vivo dehalogenation and similar biodistributions. The similarity of [211At]At-NpGT and [18F]F-NpGT indicated that these pairs of radiolabeled compounds would be helpful in radiotheranostics. Moreover, [211At]At-NpGT exhibited a dose-dependent inhibitory effect on the growth of C6 glioma-bearing mice.

Conclusions
[211At]At-NpGT exhibited a dose-dependent inhibitory effect on the tumor growth of glioma-bearing mice, and its biodistribution was similar to that of other radiohalogen-labeled amino acid derivatives. These findings suggest that radiotheranostics using [18F]F-NpGT and [123/131I]I-NpGT for diagnostic applications and [211At]At-NpGT and [131I]I-NpGT for therapeutic applications are promising.
The use of muscle ultrasound to detect critical illness myopathy in patients with sepsis: an observational cohort study
Authors: Elkholy Mostafa M. , Osman Mohammed A. , Abd El Basset Ahmed S. , El Maraghi Sameh K. , Saber Hamdy M. 
Published: February 2024

Abstract
Background
Critical illness myopathy (CIM) has negative impact on patient outcomes. We aimed to explore the diagnostic value of bedside ultrasonography for early identification of CIM in septic patients and its correlation with other diagnostic methods. This prospective observational study included 40 ICU patients diagnosed with sepsis on admission or within 48 h later according to the third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). They were evaluated using muscle ultrasound, electrodiagnostic and clinical muscle assessment (Medical Research Council, MRC) at two time points, the first was between days 2 and 5 and the second was between days 10 and 15.

Results
There was significant deterioration of neuromuscular function between the two evaluation points demonstrated by decline in MRC, abnormal nerve conduction and electromyography (EMG) and increased muscle echogenicity on ultrasonography (P ≤ 0.001). Sepsis-Related Organ Failure Assessment (SOFA) score significantly correlated with different neuromuscular assessment tools. MRC had significant correlation with myopathic EMG (P ≤ 0.001, r = − 0.869) and increased muscle echogenicity (P ≤ 0.001, r = − 0.715). Abnormal ultrasonographic muscle architecture had sensitivity of 100%, specificity of 75% and positive likelihood ratio of 4 in detecting muscle dysfunction compared to myopathic EMG.

Conclusions
Bedside peripheral muscle ultrasound echogenicity grade could be used as an additional screening test in ICU septic patients for early detection of CIM.
PICA flow-related aneurysms and posterior fossa AVM: rare association and challenging management: case presentation and review of literature
Authors: de Paule Adjiou Dognon Kossi François , Abbas Salma , Benali Oumaima , Alhassan Baba Alhaji Bin , El Manouni Othmane , Kajeou Meryem , El Ouahabi Abdessamad 
Published: February 2024

Abstract
Background
The association of an infratentorial arteriovenous malformations (AVMs) with a PICA aneurysm is very rare and the presence of associated aneurysms was an independent predictive factor of poor outcome at follow-up for posterior fossa AVMs (pfAVMs). We report the case of a 57-year-old female patient admitted to our institution with a challenging management of a pfAVM associated with multiple flow-related aneurysms of the PICA.

Case presentation
A 57-year-old patient with no medical past history was admitted to our emergency department with a sudden onset headache and severe neck stiffness. A cerebral CT Scan showed a cerebellar hematoma. Digital subtraction angiography demonstrates a right paramedian supero-posterior infratentorial AVM located at the posterosuperior part of the right cerebellar hemisphere with a small compact nidus supplied by branches of the right PICA and the right superior cerebellar artery. Venous drainage being toward the torcular. The AVM is associated with 3 flow-related aneurysms. We opted for surgical treatment of the 2 high-flow aneurysms on the distal branch of the right PICA. Patient was then sent for radiosurgery for the AVM. We opted for observation of the left small aneurysm.

Conclusion
Microsurgery for PICA aneurysms is particularly well suited because exposure through a far-lateral craniotomy is excellent. Endovascular embolization can be used to occlude the aneurysm as well as treat the AVM at the same time in certain circumstances. Clipping or coiling the aneurysm should be discussed in a multidisciplinary meeting.
Durian (Durio zibenthinus) waste: a promising resource for food and diverse applications—a comprehensive review
Authors: Gamay Rhea Abegail J. , Botecario Patricia May N. , Sanchez Philip Donald C. , Alvarado Marjun C. 
Published: February 2024

AbstractThis review article focuses on exploring the benefits, potentialities, and values of durian waste for food and other applications. In the domain of food applications, durian waste exhibits immense promise as a source of valuable compounds, including pectin, phenolic antioxidants, husk, and seed flour. Moreover, it serves as a viable material for the development of edible and bio-composite films, contributing to sustainable food packaging solutions. Beyond its relevance in the food industry, durian waste holds significance in non-food applications, particularly in the extraction and utilization of unique biomaterials, such as nanocellulose particles. These nanocellulose-based materials have garnered attention for their diverse applications including in the food industry. The various utilization methods and techniques were also discussed. The waste of durian contains nutritional values that provide great potential for valorization. In this review, it has been proved that durian waste should not be thrown away because it possesses great potential in terms of value-added products.
Can placental shear wave elastography predict preeclampsia in high-risk pregnant women during second trimester? Insights from a prospective cohort study
Authors: Singh Vikas , Kapoor Rajiv , Modi Monisha , Singhal Sangeeta , Jain Lovely 
Published: February 2024

Abstract
Background
Preeclampsia, a condition very frequently linked to maternal and fetal deaths worldwide, remains a pressing concern due to delays in recognition and response. Effective screening tests for early detection of high-risk cases and appropriate preventive measures are currently lacking. Well planned prenatal care, timely detection, monitoring, and appropriate management are vital to prevent preeclampsia-related fatalities.

Methods
This prospective study evaluated the use of shear wave elastography (SWE) in identifying placental structural issues caused by preeclampsia in high-risk pregnancies. A total of 143 high-risk pregnant women with singleton pregnancies and an anterior placental position were included in the study.

Results
Women with preeclampsia exhibited significantly elevated SWE values in both center (27.98 ± 16.12 vs. 4.57 ± 6.57 kPa) and peripheral areas of the placenta (29.14 ± 16.12 vs. 4.80 ± 7.70 kPa) when compared to non-preeclampsia women (p = 0.000). Cutoff values of 8.70 kPa and 8.15 kPa at the Center and edge of the placenta respectively, accurately predicted preeclampsia in second-trimester pregnancies, with 84.62% sensitivity and 94% specificity. However no significant difference was observed between elastography values obtained from the center and edge of the placenta.

Conclusions
In conclusion, shear wave elastography can help diagnose preeclampsia early by assessing placental stiffness.
Preliminary insights into high-intensity focused ultrasound ablation for symptomatic uterine fibroids: a first look in Egypt
Authors: Fawzi Mohamed , ElMandouh Safaa , Elbanna Alaa Eid , Narouz Micheal Ezzat , Habib Menna , Mahmoud Shrouk Shady , Badr Ahmed Said 
Published: February 2024

Abstract
Background
Uterine fibroids are common gynecological conditions that affect a significant number of women of reproductive age and may necessitate surgical intervention for their removal. However, there is a rising trend toward minimally invasive procedures, such as magnetic resonance-guided high-intensity focused ultrasound (MRgHIFU) ablation. This report provides the first experience in Egypt and North Africa on the use of MRgHIFU ablation as a therapeutic option for uterine fibroids.

Results
This study demonstrates a correlation between post-operative NPV% and symptom improvement. Following a three-month follow-up period, a significant reduction in pain scores and excessive bleeding was observed. Importantly, there was no significant elevation in hemoglobin levels (11.23 ± 2.23 to 11.25 ± 1.71 g/dL) after treatment. Furthermore, the mean non-perfused volume ratio in the treated fibroids was 46 ± 27.3% (SD) among the 20 participants. These findings suggest a favorable therapeutic outcome of MRgHIFU, with no serious adverse effects reported.

Conclusion
MRgHIFU is a noninvasive therapeutic approach for the treatment of uterine myomas, offering significant benefits in terms of pain reduction and improved quality of life. This particular study represents the pioneering clinical experience of this innovative therapy in Egypt.
Cardiac functions and pericardial thickness changes in familial Mediterranean fever patients
Authors: Yiğit Yasemin Demir , Karatoprak Özlem Karakuş , Ay Elif Güzelsoy , Karabulut Muhammed , Yılmaz Erdal , Gürgöze Metin Kaya 
Published: February 2024

Abstract
Background
The goal of the study is to ascertain how the pericardium and heart functions alter in patients with familial Mediterranean fever (FMF) both during the acute phase and the period of subclinical inflammation.

Methods
During the study, 99 patients diagnosed with FMF (35 of whom were in an FMF attack period) were recruited to this study, and 24 completely healthy children in the same age group—who did not have FMF and had not any cardiac condition that applied to visit the pediatric cardiology outpatient clinic for routine follow-up—were included as the control group.

Results
In patients with FMF, there was no discernible relationship between genetic abnormalities and pericardial thickness (p > 0.05). A significant difference was not observed in the diastolic and systolic cardiac function values between the control group and the FMF patients, with the exception of the parameters related to ejection time (ET), contraction time (IVCT), and relaxation time (IVRT). It was observed that pericardial thickness was greater in FMF patients than in study participants who did not have FMF, and this difference is statistically significant (p < 0.05).

Conclusions
It was determined that the effects of cardiac inflammation continued in children with FMF, even if they were asymptomatic. Therefore, it should be part of the follow-ups.

Key points
• In our study, cardiac functions and pericardial thickening of 99 FMF patients with and without attack were prospectively investigated.
• In ongoing follow-up of patients with FMF, we found that inflammation, which affects all serosas, also affects the pericardium during the attract and nonattack phase.
• We believe that cardiac functions, including the status of the pericardium, should be monitored as part of the long-term follow-up of FMF.
Developing interventions to improve detection of depression in primary healthcare settings in rural Ethiopia
Authors: Demissie Mekdes , Birhane Rahel , Hanlon Charlotte , Eshetu Tigist , Medhin Girmay , Minaye Abebaw , Habtamu Kassahun , Cleare Anthony J. , Milkias Barkot , Prince Martin , Fekadu Abebaw 
Published: February 2024

Background
The poor detection of depression in primary healthcare (PHC) in low- and middle-income countries continues to threaten the plan to scale up mental healthcare coverage.

Aims
To describe the process followed to develop an intervention package to improve detection of depression in PHC settings in rural Ethiopia.

Method
The study was conducted in Sodo, a rural district in south Ethiopia. The Medical Research Council's framework for the development of complex interventions was followed. Qualitative interviews, observations of provider–patient communication, intervention development workshops and pre-testing of the screening component of the intervention were conducted to develop the intervention.

Results
A multicomponent intervention package was developed, which included (a) manual-based training of PHC workers for 10 days, adapted from the World Health Organization's Mental Health Gap Action Programme Intervention Guide, with emphasis on depression, locally identified depressive symptoms, communication skills, training by people with lived experience and active learning methods; (b) screening for culturally salient manifestations of depression, using a four-item tool; (c) raising awareness among people attending out-patient clinics about depression, using information leaflets and health education; and (d) system-level interventions, such as supportive supervision, use of posters at health facilities and a decision support mobile app.

Conclusions
This contextualised, multicomponent intervention package may lead to meaningful impact on the detection of depression in PHC in rural Ethiopia and similar settings. The intervention will be pilot tested for feasibility, acceptability and effectiveness before its wider implementation.
Associations among loneliness, internal locus of control and subjective accelerated ageing in older adults who received the booster vaccination
Authors: Greenblatt-Kimron Lee , Palgi Yuval , Regev Tali , Ben-David Boaz M. 
Published: February 2024

Background
A rise in loneliness among older adults since the COVID-19 outbreak, even after vaccination, has been highlighted. Loneliness has deleterious consequences, with specific effects on perceptions of the ageing process during the COVID-19 pandemic. Coping with stressful life events and the challenges of ageing may result in a perception of acceleration of this process.

Aim
Studies have shown a buffering effect of an internal locus of control in the relationship between COVID-19 stress and mental distress. The current study examined whether loneliness predicts subjective accelerated ageing and whether internal locus of control moderates this relationship.

Method
Two waves of community-dwelling older adults (M = 70.44, s.d. = 5.95; age range 61–88 years), vaccinated three times, were sampled by a web-survey company. Participants completed the questionnaire after the beginning of the third vaccination campaign and reported again 4 months later on loneliness, internal locus of control and subjective accelerated ageing level in the second wave.

Results
Participants with higher levels of loneliness presented 4 months later with higher subjective accelerated ageing. Participants with a low level of internal locus of control presented 4 months later with high subjective accelerated ageing, regardless of their loneliness level. Participants with a high level of internal locus of control and a low level of loneliness presented with the lowest subjective accelerated ageing 4 months later.

Conclusions
The findings emphasise the deleterious effects of loneliness and low internal locus of control on older adults’ perception of their ageing process. Practitioners should focus their interventions not only on loneliness but also on improving the sense of internal locus of control to improve subjective accelerated ageing.
Rechallenge With High-Dose Methotrexate After Treatment With Glucarpidase in Adult Patients With Lymphoma
Authors: Truong Huong L. , Barreto Jason N. , Mara Kristin C. , Hampel Paul J. , Micallef Ivana N. , Nowakowski Grzegorz S. , Thanarajasingam Gita , Thompson Carrie A. , Wang Yucai , Witzig Thomas E. , Herrmann Sandra M. , Leung Nelson 
Published: February 2024

PURPOSE Limited evidence exists regarding methotrexate (MTX) resumption after patients with lymphoma receive glucarpidase for toxic MTX levels and acute kidney injury (AKI). METHODS This retrospective review included adults with lymphoma treated with glucarpidase after MTX at Mayo Clinic between January 31, 2020, and October 10, 2022. Descriptive statistics summarize patient characteristics and clinical outcomes. RESULTS Of 11 patients treated with glucarpidase after MTX, seven (64%) were rechallenged with MTX. Indications for MTX rechallenge included confirmed CNS disease (n = 6, 86%) and intravascular lymphoma (n = 1, 14%). Compared with the nonrechallenged subgroup, before receiving MTX that required glucarpidase rescue, the rechallenged patients had lower median pretreatment serum creatinine (Scr; 0.7 v 1.2 mg/dL), and none had AKI with previous MTX doses, n = 0 (0%) versus n = 2 (50%). During the MTX dose requiring glucarpidase rescue, the rechallenged group had lower median peak Scr (1.26 v 3.32 mg/dL) and lower incidence of AKI stage III (n = 1 [14%] v n = 3 [75%]), and none of the rechallenged patients required renal replacement therapy (RRT; n = 0 [0%] v n = 1 [25%]). At the first rechallenge after glucarpidase administration, the median MTX dose reduction was 56% (range, 46%-75%), and the lowest used dose when prescribed according to each treatment protocol schedule was 1.5 g/m2. Two (29%) patients experienced AKI (n = 1 stage I, n = 1 stage II) after MTX rechallenge. Zero patients required RRT, and zero required another glucarpidase administration. Six (86%) patients completed all recommended MTX doses. CONCLUSION In selected adults with lymphoma who required glucarpidase for toxic MTX levels after administration of high-dose MTX, resumption of MTX therapy at lower doses is safe. Patients selected for MTX resumption had experienced less severe AKI during the previous cycle compared with those not selected for MTX resumption.
Accelerations of large inertial particles in turbulence
Authors: Fan Yaning , Wang Cheng , Jiang Linfeng , Sun Chao , Calzavarini Enrico 
Published: February 2024

Abstract
Understanding the dynamics of material objects advected by turbulent flows is a long-standing question in fluid dynamics. In this perspective article we focus on the characterization of the statistical properties of non-interacting finite-sized massive spherical particles advected by a vigorous turbulent flow. We study the fluctuations and temporal correlations of particle accelerations and explore their behaviours with respect to the particle size and the particle mass density by means of fully resolved numerical simulations. We observe that the measured trends cannot be interpreted as the simple multiplicative combination of the two dominant effects: the spatial filtering of fluid accelerations and the added-mass–adjusted fluid-to-particle density ratio. We argue that other hydrodynamical forces or effects, e.g., preferential flow sampling, have still a significant role even at the largest particle sizes, which reach here the integral scale of turbulence.