bluuebunny/crossref_metadata_2025_split huggingface dataset:
Involvement of a guanine nucleotide-exchange protein, ARF-GEP100/BRAG2a, in the apoptotic cell death of monocytic phagocytes
Authors: Someya Akimasa , Moss Joel , Nagaoka Isao 
Published: July 2006

Abstract
We previous identified adenosine 5′-diphosphate-ribosylation factor (ARF)-guanine nucleotide-exchange protein, 100 kDa (GEP100), as a novel GEP with a molecular size of ∼100 kDa, which preferentially activates ARF6. In this study, we examined the effect of ARF-GEP100 on monocytic cell apoptosis. Overexpression of ARF-GEP100 in PMA-differentiated human monocyte-macrophage-like U937 cells and mouse macrophage RAW264.7 cells induced apoptotic cell death, which was detected by morphological changes (chromatin condensation, nucleus fragmentation, and shrinking of cytoplasm), annexin V-staining, and TUNEL assay. It is interesting that a mutant lacking the Sec7 domain, which is responsible for ARF activation, was able to induce apoptosis of the target cells to the level of that of a wild-type ARF-GEP100. Furthermore, ARF-GEP100-silencing experiments indicated that the TNF-α-induced apoptosis was significantly suppressed among ARF-GEP100-depressed cells. These observations apparently suggest that ARF-GEP100 is involved in the induction of apoptosis in monocytic phagocytes, possibly independent of ARF activation.
Return to Work Up to 5 Years After the End of Treatment Among Patients With Head and Neck Cancer
Authors: Jansen Femke , Eerenstein Simone E. J. , Arman Sara , Lissenberg-Witte Birgit I. , Hardillo Jose A. , Takes Robert P. , Brakenhoff Ruud H. , de Bree Remco , Lamers Femke , Langendijk Johannes A. , Leemans C. René , Verdonck-de Leeuw Irma M. 
Published: February 2025

ImportanceAdverse effects of cancer and its treatment may hamper return to work (RTW) among patients with head and neck cancer (HNC).ObjectivesTo investigate RTW among patients with HNC from end of treatment to 5 years after treatment and associations of RTW with sociodemographic, clinical, work-related, personal, lifestyle, physical, and psychological factors and cancer-related symptoms.Design, Setting and ParticipantsThis prospective, longitudinal, multicenter cohort study of patients with HNC used data from the Netherlands Quality of Life and Biomedical cohort. This study focused on patients younger than 65 years (with a subanalysis of patients younger than 60 years) from time of cancer diagnosis (March 2014 to June 2018) to 5 years after end of treatment (January 2019 to July 2023). Data analysis occurred from April 2023 to August 2024.ExposureStandard clinical care.Main Outcomes and MeasuresWork status was measured at 3 and 6 months, and 1, 2, 3, 4, and 5 years after treatment using an adjusted version of the Productivity Cost Questionnaire. Cox regression analyses were performed to investigate factors (baseline, 3 months, and 6 months) associated with time to RTW.ResultsA total of 184 patients with HNC younger than 65 years (mean [SD] age, 55.4 [7.0] years; 146 men [79%]) were included and 77 (42%) had oropharyngeal cancer. RTW increased from 26% (42 of 160 individuals) at 3 months to 65% (89 of 137 individuals) at 1 year, after which it reduced to 52% (51 of 98 individuals) at 5 years. At 5 years after treatment, an additional 28 of 98 participants (29%) were retired. Minor surgery (vs major surgery) was associated with faster RTW from end of treatment onwards (hazard ratio [HR], 2.73; 95% CI, 1.17-6.37). Older age (HR, 0.97; 95% CI, 0.94-0.999) and more fatigue at 3 months (HR, 0.99; 95% CI, 0.98-0.995) were associated with slower RTW from 3 months onwards. Older age was also associated with slower RTW from 6 months onwards (HR, 0.96; 95% CI, 0.93-0.998). Among the 127 patients with HNC younger than 60 years, RTW was 72% (47 individuals) at 5 years after treatment. Advanced tumor stage (HR, 0.59; 95% CI, 0.39-0.90) and more fatigue (HR, 0.99; 95% CI, 0.98-0.999) were associated with slower RTW in this group.Conclusion and relevanceThis cohort study found that the majority of patients with HNC in the Netherlands returned to work within 1 year and that certain sociodemographic and clinical factors and cancer-related symptoms were associated with time to RTW. These results may inform patients with HNC and provide insight into potential targets, such as fatigue, to improve RTW.
ALS plasma biomarkers reveal neurofilament and pTau correlate with disease onset and progression
Authors: Thomas Eleanor V. , Han Changee , Kim Woo Jae , Asress Seneshaw , Li Yingjie , Taylor Jennifer A. , Gearing Marla , Fournier Christina N. , McEachin Zachary T. , Seyfried Nicholas T. , Glass Jonathan D. 
Published: February 2025

AbstractObjectiveWe performed a pilot screen to assess the utility of the NULISA™ (Nucleic‐acid‐Linked Immuno‐Sandwich Assay) platform in the identification of amyotrophic lateral sclerosis (ALS) biomarkers.MethodsPlasma from 86 individuals (48 ALS, 18 asymptomatic C9orf72 repeat expansion carriers (AsymC9), and 20 healthy controls) was analyzed via a multiplexed NULISA™ assay that includes 120 neurodegeneration‐associated proteins. Statistical analysis of NULISA™ results was performed to identify proteins differentially expressed in plasma and their correlation with disease‐associated parameters.ResultsALS plasma showed elevation of the established biomarkers, neurofilament light chain (NEFL) and neurofilament heavy chain (NEFH). Compared to controls and AsymC9, microtubule‐associated protein tau (MAPT), phosphorylated tau 181 (pTau181), phosphorylated tau 217 (pTau217), phosphorylated tau 231 (pTau231), and phosphorylated TDP‐43 (pTDP‐43) were elevated in ALS. NEFL levels positively correlated with pTau181, pTau217, pTau231, and pTDP‐43. MAPT and pTDP‐43 were also correlated with pTau181, pTau217 and pTau231. Elevated pTau was negatively correlated with survival and ALSFRS‐R. Spinal onset ALS was associated with higher pTau181, pTau217, and pTau231.InterpretationWe confirm previous reports showing elevated pTau181 in ALS plasma and show elevation of other phosphorylated tau forms, pTau217 and pTau231, typically observed in Alzheimer's disease. We provide preliminary data showing the detection and elevation of pTDP‐43‐409/410 in a subset of ALS samples compared to healthy controls. Neurofilament and tau levels are highly correlated suggesting their elevation may reflect a common pathology and disease state. Total and phosphorylated tau are correlated with multiple disease measures, such as ALS duration, ALSFRS‐R, and site of onset.
Nanoscale Agglomeration Mechanisms of BF‐DPB:BPyMPM Donor–Acceptor Systems for Organic Optoelectronic Devices
Authors: Merkel Milena , Wiesener Philipp , Schmidt Robert , Shivhare Rishi , Doltsinis Nikos , Bratschitsch Rudolf , Amirjalayer Saeed , Vandewal Koen , Mönig Harry 
Published: February 2025

AbstractThe molecular order of the photo‐active molecules in organic solar cells and exciplex organic light emitting diodes based on donor–acceptor mixed systems has major influence on the performance. However, it is usually investigated only by indirect measurements or simulations. Here, low‐temperature scanning probe microscopy is used to directly image the molecular assembly, intermolecular bonding configuration, and domain interfaces of vacuum‐deposited donor and acceptor molecules BF‐DPB and BPyMPM on different single crystalline substrates with submolecular resolution. It is demonstrated that the position of the nitrogen atoms in the peripheric pyridine rings of BPyMPM molecules determines the occurrence of intermolecular C─H…N hydrogen bonds, metal coordination bonds, and related self‐assemblies. Two dominating self‐assembled structures of BF‐DPB are found, based either on its cis or trans configuration. In general a distinct increase in disorder occurs at the BF‐DPB:BPyMPM interface where scanning tunneling spectroscopy indicate an increase in the HOMO‐LUMO gap at disordered agglomerates of BF‐DPB. The crucial effect of the choice of substrate on the molecular order is illustrated. Photoluminescence measurements indicate a considerable increase in intersystem crossing in BF‐DPB due to molecule‐substrate interactions. These findings provide new insights for the targeted molecular design of active molecules and suitable contact layers in organic optoelectronic devices.
High‐Temperature Ternary Superhydrides: A Strategic Roadmap to Optimal Superconducting Parameters
Authors: Wrona Izabela A. , Niegodajew Paweł , Durajski Artur P. 
Published: February 2025

AbstractThis study investigates the superconducting properties of ternary hydrogen‐rich compounds to elucidate the factors that limit their critical temperature (Tc). Through a systematic analysis of an extensive dataset comprising theoretically predicted and experimentally verified ternary hydrides, the correlations between Tc and key compositional and structural parameters are examined, specifically focusing on the mass ratio between heavier atoms and hydrogen (MX/MH), hydrogen fraction (Hf), and compound electronegativity. These findings indicate that specific ranges of these parameters are more conducive to achieving elevated superconducting transition temperatures. For instance, compounds with mass ratios in the range 0 < MX/MH < 40, hydrogen fractions close to 0.8 − 0.9, and electronegativity values between 2.0 and 2.1 exhibit a higher probability of reaching Tc values above 200 K, with some extending beyond 300 K. These insights provide a robust framework for identifying promising candidates among ternary hydrides for high‐temperature superconductivity at manageable pressures. This work contributes valuable predictive criteria for accelerating the discovery and optimization of new superconducting materials that may support future technological applications at ambient or near‐ambient conditions.
Dendrite‐Free Zn Anode Enabled by Dual‐Function Itaconic Acid Electrolyte Additive Via Controllable Acidic Environment and In Situ Interfacial Protective Layer for Durable Aqueous Zinc Ion Batteries
Authors: Sun Hao , Cai Nengbin , Bai Xinyu , Chen Hongming , He Xinbo , Zhou Dan , Fan Li‐Zhen 
Published: February 2025

AbstractThe side reactions and dendritic growth largely impede the utilization of Zn anode in aqueous zinc ion batteries (AZIBs). Herein, a novel strong acidic electrolyte additive of itaconic acid (IA) is introduced to achieve highly stable Zn anode via dual functions. First, the use of trace amounts of IA can provide a steady low pH environment for the electrolyte, which is beneficial to eliminate the alkaline by‐products by neutralizing the OH− that accumulated near the Zn anode. Second, an interfacial protective layer can be in situ formed via the cross‐linking and reduction reaction between IA and Zn anode, helping to inhibit the continuous corrosion on the Zn anode and promote the formation of uniform Zn deposition. Consequently, the Zn anode achieves an ultra‐long cycle‐life (5390 h at 1 mA cm−2, 1 mAh cm−2) and an enhanced coulombic efficiency (99.86% upon 2100 cycles at 5 mA cm−2, 1 mAh cm−1). Besides, the full cell assembled with sodium vanadate delivers a high reversible capacity of 179.6 mAh g−1 over 2000 cycles at 2 A g−1. This work offers a new solution and related insights for the design and utilization of aqueous electrolytes with strong acidic additives toward highly stable Zn anode for AZIBs.
Enhanced Photoactivated Circularly Polarized Afterglow with High Dissymmetry Factor and Tunable Emission
Authors: Zhang Yuxia , Wang Yuchang , Wu Junjie , Shao Aiwen , Liu Jiao , Liu Shujuan , Li Bingxiang , Ma Yun , Zhao Qiang 
Published: February 2025

AbstractPhotoactivated circularly polarized afterglow (CPA) exhibits broad application prospects in various optoelectronic areas due to its multidimensional emission characteristics, including wavelengths, lifetimes, and chirality. Achieving photoactivated CPA with extremely high dissymmetry factor (glum) values is highly desired but considerably challenging. This work reports a bilayer assembly (R/S‐CLC‐TPB) integrating a TPB@PMMA thin film with the selective reflection of cholesteric liquid crystals. Initially, R/S‐CLC‐TPB exhibits no afterglow emission, while following 1 min of UV irradiation, it achieves an noticeable CPA with a long emission lifetime of 125 ms and a high glum value of up to 1.6. This enhancement can be attributed to the oxygen consumption properties under UV irradiation, subsequently minimizing the loss of triplet exciton. Furthermore, by employing a triplet‐singlet Förster resonance energy transfer (TS‐FRET) strategy from photoactivated organic persistent room‐temperature phosphorescence donor to fluorescent dye acceptor, the afterglow color is successfully modulated from green to orange. Ultimately, these materials demonstrate promising capabilities for advanced multi‐level information encryption by utilizing their tunable afterglow color, long emission lifetimes, and high glum values to create multiple encryption layers that can be selectively accessed and decoded based on photoactivation and chiroptical properties.
Stretchable and Permeable Liquid Metal Micromeshes Featuring Strain‐Insensitive Resistance Through In Situ Structural Transformations
Authors: Wang Qian , Sun Yuping , Qin Changqing , Lin Yong , Fang Ting , Yang Cheng , Zhang Jinheng , Lu Yan‐qing , Kong Desheng 
Published: February 2025

AbstractGallium‐based liquid metals hold promises for applications in stretchable electronics and beyond. However, these materials often encounter notable resistance increases during stretching and have negligible permeability to gases and liquids. This study presents an in situ structural transformation mechanism to create stretchable and permeable liquid metal micromeshes with strain‐insensitive resistance. These micromeshes are fabricated by spin‐coating liquid metal onto microfiber textiles and subjecting them to several stretching cycles. Consequently, the micromeshes transform from a smooth finish to wrinkled textures due to the growth in their oxide nanoskins. The distinct microstructure alters the stretching‐relaxing mode to folding‐unfolding, thereby minimizing fluctuations in resistance. The practical significance of this development is demonstrated through the fabrication of wearable heaters and LED matrices using transformed liquid metal micromeshes. Moreover, when integrated into Janus textiles featuring unidirectional water transport, these micromesh conductors act as sensing electrodes capable of acquiring high‐fidelity biopotentials, even during intense sweating. These advancements highlight the capability of ambient air as a powerful reactive environment for tailoring the properties of microscale liquid metals.
Flexible Multilayer Metasurfaces: Design and Applications on Foldable and Conformable Substrates
Authors: Shi Yilin , Dai Hao , Tang Renjie , Wu Jianghong , Wu Yingchun , Song Jieren , Si Yalan , Lin Hongtao , Li Lan 
Published: February 2025

AbstractMetasurfaces offer effective optical modulation and compact solutions for integrated optoelectronic circuits. Multilayer metasurfaces surpass single‐layer counterparts in functionalities, enabling more complex manipulation of phase, amplitude, and polarization. However, existing multilayer metasurfaces lack reconfigurability based on flexible configurations, limiting their applications in dynamic and shape‐constrained scenarios. Here, a multilayer metasurface platform utilizing a foldable and conformable flexible structure is introduced. The foldability enables coupled or decoupled multilayer metasurfaces by reconfigurable folding alignment. To validate this technology, the previously established flexible metasurface fabrication techniques are employed. The coupled multilayer metasurface is demonstrated by an inverse‐designed 1D multilayer zoom metalens that achieves a numerical aperture (NA) from 0.80 to 0.12 by altering the polarization state of incident light from X‐ to Y‐polarization. For the decoupled multilayer metasurface, a refractive‐meta hybrid system is demonstrated, featuring metalens that operates on curved surfaces and can switch between a near‐diffraction‐limited telephoto mode and an 80° wide‐angle mode. The exceptional performance of the two validated devices on this platform highlights its superiority as a comprehensive design platform for multilayer metasurfaces. Notably, its potential for operation on non‐planar forms offers promising applications for miniaturized optoelectronic devices such as augmented reality displays and wearable medical devices.
Modulating Linker Conjugation and Flexibility of Aggregation‐Induced Emission Covalent Organic Framework for Enhanced Luminescence
Authors: Wan Haifei , Wang Xingxiang , Nie Qinqin , Wang Xinyi , Wang Li , Song Yonghai 
Published: February 2025

AbstractIn order to inhibit non‐radiative decay pathways of covalent‐organic frameworks (COFs), a strategy is proposed to block intralayer conjugation and interlayer π–π stacking by using flexible aggregation‐induced emission (AIE) building blocks (4′,4′′′,4′′′′′,4′′′′′′′‐(1,2‐ethenediylidene) tetrakis[1,1′‐biphenyl]‐4‐carbaldehyde (TFBE)) connected by weakly conjugated flexible linker. By using the flexible TFBE as building blocks and changing the conjugation and flexibility of linker, TFBE‐COFs with different luminescence properties are obtained. Experimental and theoretical results show that these TFBE‐COFs have high crystallinity and large layer spacing, among which the photoluminescence quantum yield of hydrazone (Hz)‐COFTFBE‐ODH (oxalyl dihydrazide (ODH)) in solid state reaches 26.28%, which is superior to most of the COFs reported so far. The excellent luminescence is attributed to the non‐planar geometry and flexibility of TFBE, which inhibits aggregation‐induced quenching. Moreover, the π‐electron delocalization‐induced non‐radiative leaps are suppressed by weakly conjugated flexible linker, which further enhances the photoluminescence of TFBE‐COFs. The Hz‐COFTFBE‐ODH exhibits excellent sensing performance for trace tetracycline, the detection limit is 0.15 µm. In addition, a white light‐emitting diodes coated with Hz‐COFTFBE‐ODH is manufactured to achieve high‐quality white light emission. This study provides a new strategy for the design and application of high‐emission COFs.
Fabrication of a Phosphor‐in‐Silica Glass Spectral Converter via Injection Molding for Stable and High‐Power Broadband LEDs
Authors: Mohamed Moushira. A. , Ali Mohamed. A. , Guo Shaorun , Liu Xiaofeng , Sun Shengzhi , Qiu Jianrong 
Published: February 2025

AbstractThe encapsulation of phosphor particles into a silica glass (PiSG) matrix leads to the formation of an efficient and chemically durable spectral converter, which is a promising candidate for the fabrication of stable and high‐power phosphor‐converted white light‐emitting‐diodes (pc‐wLEDs). Here, high‐throughput fabrication of transparent PiSG spectral converters based on Y3Al5O12:Ce3+, Mg2Al4Si5O18:Eu2+, and Y3Al5O12:Cr3+ is demonstrated via injection molding followed by pressureless sintering. The as‐fabricated PiSG exhibits broadband emission covering the visible and near‐infrared (vis‐NIR) spectral regions (i.e., 500–900 nm) with a high‐luminescence efficiency (> 85%) and high‐chemical and thermal stabilities, retaining more than 90% of its emission intensity at 200 °C. Consequently, high‐power pc‐vis‐NIR‐LEDs (10 W) are manufactured using the injection molded PiSG spectral converters, which showed excellent luminescence performance (i.e., luminous efficiency (LE) = 115 Im W−1, correlated‐color‐temperature (CCT) = 4531 K, and color‐rendering‐index (Ra) = 90.1 at 50 mA and input power of 0.45 W). This work enables the fabrication of stable and high‐power broadband LEDs with a low cost and outstanding optical properties, making the as‐fabricated pc‐vis‐NIR‐LEDs based on PiSG spectral‐converter a favorable device for lighting and bioimaging applications.
Photocatalysis for Sustainable Nitrogen Fixation: Fundamentals, Catalyst Design, Nanoarchitectonics, Applications, and Future Prospects
Authors: Sharma Manisha , Kumar Ashish , Sajwan Devanshu , Kumari Kamlesh , Mishra Bhagyashree Priyadarshini , Krishnan Venkata 
Published: February 2025

AbstractPhotocatalytic nitrogen fixation has evolved as potential sustainable technique for producing ammonia in contrast to Haber‐Bosch (HB) process. In this process, semiconductor‐based materials are utilized in the presence of light and water, thereby making it less energy‐intensive and more eco‐friendly. However, photocatalytic materials utilized in nitrogen fixation have several disadvantages, including limited chemisorption and activation of nitrogen, low light absorption, rapid charge recombination, and sluggish kinetics. To overcome these issues, design of the catalyst and tailoring of active surface sites are vital so that enhanced performance can be achieved. Also, there is debate about the correct determination of ammonia due to interference by nitrogenous impurities. Taking all these factors into consideration, this review examines the recent reports on enhanced photocatalytic performance of defects modified (vacancy and doping), facet‐engineered, and heterojunction‐based catalysts for nitrogen fixation. The different ammonia quantification techniques like Nessler's reagent, indophenol method, ion chromatography (IC), etc. have been discussed in detail along with issues associated with them. Finally, the existing challenges and outlook of this emerging technology are presented. It is expected that this review will assist the researchers in understanding the current state of this field and effectively implementing it to pave the way for future advancements.
Loss of MNX1 Sensitizes Tumors to Cytotoxic T Cells by Degradation of PD‐L1 mRNA
Authors: Li Zhengzheng , Chen Lei , Zhang Ge , Wang Shuang , Xu Enhang , Teng Jinglei , Xu Jiancheng , Peng Fang , Min Qingjie , Wang Zhuoya , Shao Shujuan , Zhao Lianmei , Shan Baoen , Wang Yang , Zhan Qimin , Liu Xuefeng 
Published: February 2025

AbstractImmune checkpoint blockade (ICB) therapy, targeting programmed cell death ligand‐1 (PD‐L1)/programmed cell death protein 1 (PD‐1) axis and cytotoxic T‐lymphocyte‐associated protein 4 (CTLA‐4), has exhibited amazing clinical outcomes in various types of cancers. However, only a small portion of patients benefit from ICB therapy, indicating that the mechanism underlying immune checkpoint is still unclear. Here, it is reported that motor neuron and pancreas homeobox 1 (MNX1), a homeobox domain‐containing transcription factor, contributes to the tumor immune escape. MNX1 increases PD‐L1 expression in cancer cells by stabilizing PD‐L1 mRNA rather than activating transcription. Mechanistically, MNX1 exists in the cytoplasm of cancer cells and interacts with Y‐box binding protein 1 (YBX1), a multifunctional DNA/RNA‐binding protein, to enhance the binding of YBX1 to PD‐L1 mRNA. MNX1 ablation activates cytotoxic T cell‐mediated anti‐tumor immunity and sensitizes CTLA‐4 blockade therapy. Moreover, MNX1 also facilitates tumor progression in an immune‐independent manner in cancer cells. In addition, MNX1 is upregulated by its adjacent long non‐coding RNA MNX1‐AS1 via HECT and RLD domain containing E3 ubiquitin protein ligase 2 (HERC2). Together, these results reveal MNX1 as a novel immune checkpoint regulator with promising therapeutic potential.