bluuebunny/crossref_metadata_2025_split huggingface dataset:
TIGIT regulates CD4+ T cell immunity against polymicrobial sepsis
Authors: Zhong Xuexin , Xie Haiping , Wang Shuang , Ren Tingting , Chen Junlin , Huang Yuefang , Yang Niansheng 
Published: March 2024

BackgroundSepsis is one of the major causes of death and increased health care burden in modern intensive care units. Immune checkpoints have been prompted to be key modulators of T cell activation, T cell tolerance and T cell exhaustion. This study was designed to investigate the role of the negative immune checkpoint, T cell immunoglobulin and ITIM domain (TIGIT), in the early stage of sepsis.MethodAn experimental murine model of sepsis was developed by cecal ligation and puncture (CLP). TIGIT and CD155 expression in splenocytes at different time points were assessed using flow cytometry. And the phenotypes of TIGIT-deficient (TIGIT-/-) and wild-type (WT) mice were evaluated to explore the engagement of TIGIT in the acute phase of sepsis. In addition, the characteristics were also evaluated in the WT septic mice pretreated with anti-TIGIT antibody. TIGIT and CD155 expression in tissues was measured using real-time quantitative PCR and immunofluorescence staining. Proliferation and effector function of splenic immune cells were evaluated by flow cytometry. Clinical severity and tissue injury were scored to evaluate the function of TIGIT on sepsis. Additionally, tissue injury biomarkers in peripheral blood, as well as bacterial load in peritoneal lavage fluid and liver were also measured.ResultsThe expression of TIGIT in splenic T cells and NK cells was significantly elevated at 24 hours post CLP.TIGIT and CD155 mRNA levels were upregulated in sepsis-involved organs when mice were challenged with CLP. In CLP-induced sepsis, CD4+ T cells from TIGIT-/- mice shown increased proliferation potency and cytokine production when compared with that from WT mice. Meanwhile, innate immune system was mobilized in TIGIT-/- mice as indicated by increased proportion of neutrophils and macrophages with potent effector function. In addition, tissue injury and bacteria burden in the peritoneal cavity and liver was reduced in TIGIT-/- mice with CLP induced sepsis. Similar results were observed in mice treated with anti-TIGIT antibody.ConclusionTIGIT modulates CD4+ T cell response against polymicrobial sepsis, suggesting that TIGIT could serve as a potential therapeutic target for sepsis.
Mapping seabird vulnerability to offshore wind farms in Norwegian waters
Authors: Fauchald Per , Ollus Victoria Marja Sofia , Ballesteros Manuel , Breistøl Arild , Christensen-Dalsgaard Signe , Molværsmyr Sindre , Tarroux Arnaud , Systad Geir Helge , Moe Børge 
Published: March 2024

IntroductionOffshore wind energy development (OWED) has been identified as a major contributor to the aspired growth in Norwegian renewable energy production. Spatially explicit vulnerability assessments are necessary to select sites that minimize the harm to biodiversity, including seabird populations. Distributional data of seabirds in remote areas are scarce, and to identify vulnerable areas, species, and seasons it is necessary to combine data sets and knowledge from different sources.MethodsIn this study, we combined seabird tracking data, data from dedicated coastal and seabird at-sea surveys, and presence-only data from citizen science databases to develop habitat suitability maps for 55 seabird species in four seasons throughout the Norwegian exclusive economic zone; in total 1 million km2 in the Northeast Atlantic. The habitat suitability maps were combined with species-specific vulnerability indicators to yield maps of seabird vulnerability to offshore wind farms (OWFs). The resulting map product can be used to identify the relative vulnerability of areas prospected for OWED with respect to seabird collision and habitat displacement. More detailed assessments can be done by splitting the spatial indicators into seasonal and species-specific components.Results and discussionAssociated with higher diversity of seabirds near the coast, the cumulative vulnerability indicator showed a strong declining gradient from the coast to offshore waters while the differences in vulnerability between ocean areas and seasons were negligible. Although the present map product represents the best currently available knowledge, the indicators are associated with complex uncertainties related to known and unknown sampling biases. The indicators should therefore be used cautiously, they should be updated regularly as more data become available, and we recommend that more detailed environmental impact assessments based on dedicated seabird surveys, tracking of birds from potentially affected populations and population viability analyses are conducted in areas ultimately selected for OWED.
Aging effects on the encoding/retrieval flip in associative memory: fMRI evidence from incidental contingency learning
Authors: Schneider Else , Rajkovic Marko , Krug Rudolf , Caviezel Marco P. , Reichert Carolin F. , Bieri Oliver , Schmidt André , Borgwardt Stefan , Leyhe Thomas , Linnemann Christoph , Brühl Annette B. , Lang Undine E. , Melcher Tobias 
Published: March 2024

IntroductionAssociative memory is arguably the most basic memory function and therein constitutes the foundation of all episodic and semantic memory processes. At the same time, the decline of associative memory represents a core feature of age-related cognitive decline in both, healthy and pathological (i.e., dementia-related) aging. The neural mechanisms underlying age-related impairments in associative memory are still not fully understood, especially regarding incidental (i.e., non-intentional) learning.MethodsWe investigated the impact of age on the incidental learning and memory retrieval of face-name combinations in a total sample of 46 young (N = 23; mean age = 23.39 years) and elderly (N = 22, mean age = 69.05 years) participants. More specifically, particular interest was placed in age-related changes in encoding/retrieval (E/R) flips, which denote a neural antagonism of opposed activation patterns in the same brain region during memory encoding and retrieval, which were assessed using fMRI.ResultsAccording to our hypothesis, the results showed a significant age-related decline in the retrieval performance in the old group. Additionally, at the neural level, we discovered an abolished E/R flip in the right anterior insula and a joint but reduced E/R flip activation magnitude in the posterior middle cingulate cortex in older subjects.DiscussionIn conclusion, the present findings suggest that the impaired neural modulation of the E/R flip in the right aIC might be a sensitive marker in the early detection of neural aging.
Association between oxidative balance score and metabolic syndrome and its components in US adults: a cross-sectional study from NHANES 2011–2018
Authors: Lu Yi , Wang Meixiang , Bao Jiaxin , Chen Dashuang , Jiang Hao 
Published: March 2024

BackgroundMetabolic syndrome (MetS) is a global health concern that threatens human well-being. The oxidative balance score (OBS) is a tool to identify the level of oxidative stress that is correlated with MetS risk. However, association between OBS and MetS and its components has not been reported.MethodsThis cross-sectional study included adult individuals with complete OBS and MetS data from National Health and Nutrition Examination Survey (NHANES) 2011–2018. A weighted logistic regression analysis was conducted to identify the association of the total, dietary, and lifestyle OBS scores with MetS. Subgroup analyses and restricted cubic splines were used to further explore associations.ResultsIn total, 10,025 eligible adult individuals (51.48% were males at a median age of 46 years) were included, with a MetS prevalence of 29.98%. In fully adjusted model, higher total OBS was associated with reduced risk of MetS (Q3 vs. Q1: odds ratio [OR] = 0.57, 95% confidence interval [CI], 0.46–0.71, p &lt; 0.001; Q4 vs. Q1: OR = 0.42, 95% CI, 0.33–0.53, p &lt; 0.001; P for trend &lt;0.001). Significant differences were observed in the relationship between dietary OBS and lifestyle OBS and MetS risk (continuous dietary OBS: OR = 0.97, 95% CI, 0.96–0.98, p &lt; 0.001; continuous lifestyle OBS: OR = 0.61, 95% CI, 0.58–0.64, p &lt; 0.001), as well as negative relationship between total OBS and risk of five MetS components (all p &lt; 0.05). Subgroup analysis showed marital status modified the negative association between OBS and MetS in subgroup analysis (P for interaction = 0.014). Moreover, a nonlinear correlation between OBS and MetS (including its components) was found, further elucidating associations (all p &lt; 0.05). Restricted cubic splines demonstrated not obviously U-shape correlation between OBS and MetS components (elevated triglyceride and blood pressure).ConclusionThis study suggests a strong association between the OBS and MetS and its components. Our data indicated that a higher OBS score was correlated with a decreased risk of MetS and its components in a nonlinear manner. Hence, the OBS may serve as an effective marker for identifying individuals with MetS, with a higher score indicating a predominance of more antioxidants.
Sometimes here, sometimes there—Differential effects of social challenge and hindrance stressors depending on the work location
Authors: Rigotti Thomas , Schilbach Miriam , Kern Marcel 
Published: March 2024

IntroductionAs a result of the COVID-19 pandemic, the number of employees working from home has more than tripled in Germany from 2019 to 2022. While earlier research on remote work primarily focused on discerning variations among employee groups, this study delves into the realm of intra-individual effects. Specifically, we investigate how social stressors relate to exhaustion and positive affect at the end of the day within the context of different work settings.MethodsThis research draws insights from a sample comprising 99 employed individuals who diligently responded to surveys over a span of up to 10 working days (with an average of 6 days) after work and prior to bedtime.ResultsAlthough the absolute level of encountered social stressors exhibited no noteworthy difference between working at home or the premise of the employer, the relationship to exhaustion was moderated by the work location. Remarkably, the positive link between challenge-oriented social stressors and exhaustion manifested solely on days spent working from home. In contrast, social hindrance stressors exhibited a positive association with exhaustion exclusively on days when employees were operating within the organizational premise.DiscussionThese findings offer preliminary indications that the significance of specific stressors might indeed fluctuate based on the physical location of work. In essence, this study sheds light on the nuanced interplay between stressors and employee wellbeing, thereby adding depth to our comprehension of the remote work landscape.
COVID-19 vaccines breakthrough infection and adverse reactions in medical students: a nationwide survey in Iran
Authors: Allahgholipour Amirreza , Safavi-Naini Seyed Amir Ahmad , Shekarriz Foomany Zahra , Eskandari Abdolvahab , Nazari Rostami Hossein , Honarvar Mohamad Javad , Mohammadi Mohammad , Khalili Parnian , Ilaghi Mehran , Afshar Hossein , Amini Baghbadorani Ali , Moghimi Hamid Reza , Chamani Goorabi Alireza , Mehrparvar Amirreza , Safari Mehdi , Nakhli Ashraf Sadat , Mahmoudabadi Mohammad , Seifadini Adib , Sheikhansari Sobhan , Khojastehfar Sadaf , Mahdavi Parisa , Mohammadi Maede , Ashrafi Barzideh Siyamak , Akbarzadeh Nadia , Delavarpour Moghadam Seyed Hosein , Tavakoli Pirzaman Ali , Barary Mohammad , Emamhadi MohammadAli 
Published: March 2024

IntroductionThere are different types of COVID-19 vaccines approved worldwide. Since no national studies focus on vaccine-related adverse reactions and breakthrough cases, this study aimed to investigate the rate of adverse events and COVID-19 infection in medical students in Iran.MethodsThis retrospective cohort study included Iranian medical students who received two doses of COVID-19 vaccines. The medical team gathered the demographic characteristics, comorbidities, type of vaccine, adverse events following vaccination, and history of COVID-19 infection data through a phone interview. The frequency of adverse events and breakthrough infection was stratified by vaccine type (ChAdOx1-S, Gam-COVID-Vac, and BIBP-CorV).ResultsA total of 3,591 medical students enrolled in this study, of which 57.02% were females, with a mean age of 23.31 + 4.87. A PCR-confirmed and suspicious-for-COVID-19 breakthrough infection rate of 4.51 and 7.02% was detected, respectively. There was no significant relation between breakthrough infection and gender, BMI, blood groups, and comorbidities. However, there was a significant difference in breakthrough infection rate among different types of vaccines (p = 0.001) and history of COVID-19 infection (p = 0.001). A total of 16 participants were hospitalized due to COVID-19 infection after vaccination for reasons such as dyspnea, abnormal imaging, or decreased oxygen saturation. No severe infection or death was observed in the studied population.ConclusionVaccination prevented severe COVID-19 infection, although a high breakthrough infection rate was evident among Iranian medical students during the Delta variant’s peak. Vaccine effectiveness may be fragile during emerging new variants and in high-exposure settings. Moreover, adverse events are rare, and the benefits of vaccination outweigh the side effects. However, many limitations challenged this study, and the results should be cautious.
Association of Urinary Dickkopf-3 Levels with Cardiovascular Events and Kidney Disease Progression in Systolic Blood Pressure Intervention Trial
Authors: Peschard Vanessa-Giselle , Scherzer Rebecca , Katz Ronit , Chen Teresa K. , Bullen Alexander L. , Campos Kasey , Estrella Michelle M. , Ix Joachim H. , Shlipak Michael G. 
Published: March 2024

Key Points

In unadjusted analyses, elevated urinary Dickkopf-3 levels were strongly associated with higher risks of cardiovascular disease, ESKD, AKI, and mortality.However, associations were substantially weakened after adjustment for eGFR and albuminuria, suggesting limited prognostic value.

Background
Urinary Dickkopf-3 (uDKK3) is a tubular epithelial-derived profibrotic protein secreted into the urine under tubular stress. It is associated with kidney disease progression in persons with CKD and diabetes and postoperative and contrast-associated AKI. We explored associations of uDKK3 with cardiovascular disease (CVD), kidney, and mortality outcomes within the subset of Systolic Blood Pressure Intervention Trial participants with nondiabetic CKD.

Methods
We included 2344 participants with eGFR <60 ml/min per 1.73 m2 at baseline. We used Cox proportional hazards models to evaluate associations of uDKK3 with CVD (acute decompensated heart failure, myocardial infarction, acute coronary syndrome, stroke, or CVD death), kidney outcomes (incident ESKD, incident AKI, and eGFR decline ≥30%), and all-cause mortality. We used linear mixed models to examine the association of uDKK3 with annual percentage change in eGFR. Models were adjusted for demographic and clinical characteristics, eGFR, and albuminuria.

Results
Over a median follow-up of 3.5 years, there were 292 CVD, 73 ESKD, 183 AKI, 471 eGFR decline, and 228 mortality events. In multivariable models without adjustment for eGFR and albuminuria, uDKK3 was strongly associated with CVD, ESKD, AKI, eGFR decline ≥30%, and mortality. However, after further adjustment for eGFR and albuminuria, uDKK3 was no longer associated with risks for composite CVD (hazard ratio, 1.07; 95% confidence interval, 0.92 to 1.23), ESKD (0.80; 0.62 to 1.02), AKI (1.01; 0.85 to 1.21), eGFR decline ≥30% (0.88; 0.79 to 0.99), or mortality (1.02; 0.87 to 1.20). For the linear eGFR change outcome, higher uDKK3 also had no association in the fully adjusted model (−0.03; −0.41 to 0.36).

Conclusions
Among individuals with hypertension and nondiabetic CKD, higher uDKK3 appeared to have associations with a greater risk of CVD events, incident ESKD, incident AKI, eGFR decline ≥30%, and mortality but these associations were not independent of eGFR and albuminuria.
Strategi Pendekatan Orientasi Kewirausahaan, Orientasi Pasar dan Pembelajaran Organisasi dalam Meningkatkan Kinerja UMKM Makanan Halal Khas Cirebon
Authors: Yuliana Rahmi , Widowati Maduretno 
Published: March 2024

The purpose of this study was to examine the effect of entrepreneurial orientation, market orientation and organizational learning on the quality of strategic assets, and also the effect of the quality of strategic assets on the performance of the Cirebon halal food SMEs. This research was conducted on the Cirebon Typical Halal Food UMKM, the respondents used were 200 respondents. The data was processed using Structural Equation Modeling (SEM) with the help of the Analysis of Moment Structure (AMOS) program version 23.0. Based on the results of the analysis, it can be concluded that the effect of entrepreneurial orientation on strategic asset quality shows a CR value of -0.338 and with a probability of 0.735, testing the effect of entrepreneurial orientation on business performance shows a CR value of 2.499 and with a probability of 0.012, market orientation towards strategic asset quality shows a CR value. of 2.344 and with a probability of 0.035, market orientation to business performance shows a CR value of 2.362 and with a probability of 0.031, testing organizational learning on strategic asset quality shows a CR value of 4.881 and with a probability of 0.001., testing the effect of organizational learning on business performance shows a CR value of 1.351 and with a probability of 0.177, the effect of strategic asset quality on business performance shows a CR value of 2.067 and a probability of 0.039. Kata Kunci : Orientasi Kewirausahaan, Orientasi Pasar, Pembelajaran Organisasional, Kualitas Aset stratejik, Kinerja Bisnis
Faktor-Faktor Yang Mempengaruhi Kinerja Karyawan CV Tri Setya Abadi
Authors: Octavia Ayu Nurafni , Prihatini Puja , Saraswati Diah Cahyani 
Published: March 2024

The purpose of this study was to determine whether work motivation, work discipline, and job satisfaction affect employee performance at CV Tri Setya Abadi. The population in this study were 37 employees at CV Tri. Setya Abadi and included in this research sample. The research method to be carried out is quantitative research and this research is categorized as explanatory research, namely research that aims to explain the causal relationship between variables through hypothesis testing. The type of data used is primary data. Methods of data collection using questionnaires and documentation. The analysis technique used is the validity and reliability test, the classical assumption test (normality test, multicollinearity test and heteroscedasticity test), t test, F test and the coefficient of determination (R2). Testing the hypothesis of this study with the help of SPSS version 25. The results of this study indicate that partially there is a positive and significant influence between motivational variables and performance variables on CV. Tri Setya Abadi, there is a positive and significant influence between discipline variables and performance variables on CV. Tri Setya Abadi, there is a positive and significant influence between job satisfaction variables and performance variables on CV. Tri Setya Abadi and work motivation, work discipline and job satisfaction simultaneously have a positive and significant effect on employee performance at CV. Tri Setya Abadi.
Management of plastic waste as industrial raw material in the perspective of protecting the environment the environment
Authors: Biyanto Biyanto , Fadlan Fadlan , Prasetiasari Christiani 
Published: March 2024

Purpose: The purpose of this study was to determine the legal regulation of plastic waste management as an industrial raw material from the perspective of protecting the environment, and how the implementation, constraining factors, and efforts to manage plastic waste as industrial raw material from the perspective of protecting the environment.
Research methodology: The research method of this journal is normative juridical (legal research) through a literature study with an empirical juridical approach (sociological juridical) through field studies aimed at empirically obtaining legal knowledge.
Results: The results showed that the legal regulation of plastic waste management as an industrial raw material from the perspective of protecting the environment; Article 36 of Law Number 32 of 2009 regulates activities that are required to have an EIA or UKL-UPL must have an environmental permit, and environmental permits are issued by the Minister, governor, or regent/mayor. Specifically, plastic waste management is also regulated in Article 4 of the Government Regulation of the Republic of Indonesia (Number 22 of 2021). The implementation of plastic waste management as an industrial raw material from the perspective of protecting the environment at PT Agromas Batam Pratama resulted in the evaluation of wastewater quality exceeding the predetermined quality standards. There are various obstacles, such as policy, availability of plastic waste, technology, and human resource awareness. These constraints affect the management of plastic waste in the context of environmental protection. However, the government's supervisory efforts, namely periodic evaluation, have the potential to cause environmental pollution.
Using copper-coated round rod electrodes at various depths in freshwater marshes
Authors: Putra Dian Eka , Nawawi Zainuddin , Jambak M. Irfan 
Published: March 2024

Purpose: High-voltage electrical equipment requires a grounding installation in order to protect lives in freshwater swamps with a hydrogen potential of 6.75. To build a grounding structure, it is required to know the resistance value and grounding materials, namely copper-coated rod electrodes at different depths.
Research methodology: The research was conducted in a freshwater swamp close to the shampooing substation using field observations and direct measurement of soil resistance values, followed by a literature review and comparisons using COMSOL simulation and FEM Analysis.
Results: The results of direct research and simulations indicate that in order to accomplish a grounding resistance value < 5 ohms according to the PUIL 2011 standard for a single rod system made of copper, it is necessary to optimize the depth of the grounding electrode within a range of 10 meters, which differs from the simulation results of ground resistance measurement and the Comsol application. The percentage error is 1.05%.
Limitations: This research analyzes the results of measurements and grounding analysis using Comsol Multiphysics at a depth of 1 meter for a particular type of copper-coated round rod electrode at depths of 1, 1.5, and 2 meters.
Contributions: The results of the study offer information on the usefulness of grounding resistance in freshwater wetlands with a pH greater than 6, where several rod electrode types are utilized to compare future research.