bluuebunny/crossref_metadata_2025_split huggingface dataset:
The publication and citation impact profiles of Angewandte Chemie and the Journal of the American Chemical Society based on the sections of Chemical Abstracts: A case study on the limitations of the Journal Impact Factor
Authors: Neuhaus Christoph , Marx Werner , Daniel Hans‐Dieter 
Published: September 2008

AbstractThe Journal Impact Factor (JIF) published by Thomson
Reuters is often used to evaluate the significance and performance of
scientific journals. Besides methodological problems with the JIF,
the critical issue is whether a single measure is sufficient for characterizing the impact of journals, particularly the impact of multidisciplinary and wide‐scope journals that publish articles in a broad range of research fields. Taking Angewandte Chemie International Edition and the Journal of the American Chemical Society as examples, we examined the two journals' publication and impact profiles across the sections of Chemical Abstracts and compared the results with the JIF. The analysis was based primarily on Communications published in Angewandte Chemie International Edition and the Journal of the American Chemical Society during 2001 to 2005. The findings show that the information available in the Science Citation Index is a rather unreliable indication of the document type and is therefore inappropriate for comparative analysis. The findings further suggest that the composition of the journal in terms of contribution types, the length of the citation window, and the thematic focus of the journal in terms of the sections of Chemical Abstracts has a significant influence on the overall journal citation impact. Therefore, a single measure of journal citation impact such as the JIF is insufficient for characterizing the significance and performance of wide‐scope journals. For the comparison of journals, more sophisticated methods such as publication and impact profiles across subject headings of bibliographic databases (e.g., the sections of Chemical Abstracts) are valuable.
SIRT1 longevity factor suppresses NF‐κB ‐driven immune responses: regulation of aging via NF‐κB acetylation?
Authors: Salminen Antero , Kauppinen Anu , Suuronen Tiina , Kaarniranta Kai 
Published: September 2008

AbstractThe aging process involves changes in immune regulation, i.e. adaptive immunity declines whereas innate immunity becomes activated. NF‐κB signaling is the master regulator of the both immune systems. Two recent articles highlight the role of the NF‐κB system in aging and immune responses. Adler et al1 showed that the NF‐κB binding domain is the genetic regulatory motif which is most strongly associated with the aging process. Kwon et al2 studying HIV‐1 infection and subsequent immune deficiency process demonstrated that HIV‐1 Tat protein binds to SIRT1 protein, a well‐known longevity factor, and inhibits the SIRT1‐mediated deacetylation of the p65 component of the NF‐κB complex. As a consequence, the transactivation efficiency of the NF‐κB factor was greatly potentiated, leading to the activation of immune system and later to the decline of adaptive immunity. These observations support the scenario where immune responses and aging process can be enforced by the potentiation of NF‐κB transactivation efficiency. Longevity factors, such as SIRT1 and its activators, might regulate the efficiency of the NF‐κB signaling, the major outcome of which is inflamm‐aging via proinflammatory responses. BioEssays 30:939–942, 2008. © 2008 Wiley Periodicals, Inc.
Opsins and cell fate in the Drosophila Bolwig organ: tricky lessons in homology inference
Authors: Friedrich Markus 
Published: September 2008

AbstractThe Drosophila Bolwig organs are small photoreceptor bundles that facilitate the phototactic behavior of the larva. Comparative literature suggests that these highly reduced visual organs share evolutionary ancestry with the adult compound eye. A recent molecular genetic study produced the first detailed account of the mechanisms controlling differential opsin expression and photoreceptor subtype determination in these enigmatic eyes of the Drosophila larva. Here, the evolutionary implications are examined, taking into account the dynamic diversification of opsin genes and the spatial regulation of opsin homolog expression in other insects. It is concluded that, consistent with their common evolutionary roots, the Drosophila larval and adult eyes use the same mechanisms for the regulation of opsin expression and photoreceptor cell fate specification. Strikingly, the structurally highly derived Bolwig organs retained a more ancestral state of opsin expression and regulation. Inconspicuous in size, the Drosophila larval eyes deliver useful lessons in the reconstruction of homology between neuronal cell types with gene expression data, and on the conservative nature of gene regulatory network evolution during the emergence of novel organs from ancestral templates. BioEssays 30:980–993, 2008. © 2008 Wiley Periodicals, Inc.
Compagen, a comparative genomics platform for early branching metazoan animals, reveals early origins of genes regulating stem‐cell differentiation
Authors: Hemmrich Georg , Bosch Thomas C.G. 
Published: September 2008

AbstractLarge‐scale species comparisons at genome and expressed sequence tag (EST) levels have revealed that early branching metazoans such as sponges and cnidarians share many if not most of their genes with the allegedly advanced vertebrates including man. The ancestor of all animals may thus have been much more complex than anticipated. To facilitate and support analysis of genomic and transcriptomic resources in early branching metazoans, we have established a local bio‐computational platform, Compagen (http://www.compagen.org). The platform contains searchable databases with selected raw genomic and EST sequence datasets from sponges and cnidarians up to the lower vertebrates. In addition to the public datasets, Compagen also provides processed data like CAP3 assembled ESTs or predicted peptides. Evaluating the efficacy of the platform by screening for genes reported to be essential in controlling stem‐cell behavior in higher organisms uncovered ancient origins for some but not all components of the vertebrate stem‐cell system. BioEssays 30:1010–1018, 2008. © 2008 Wiley Periodicals, Inc.
How Mycobacterium tuberculosis subverts host immune responses
Authors: Józefowski Szczepan , Sobota Andrzej , Kwiatkowska Katarzyna 
Published: September 2008

AbstractMycobacterium tuberculosis is the causative agent of pulmonary tuberculosis which has infected one third of the mankind and causes 2–3 million deaths worldwide each year. The persistence of the infection ensues from the ability of M. tuberculosis to subvert host immune responses in favor of survival and growth of mycobacteria in macrophages. The mechanisms by which M. tuberculosis manipulates the host immune system have only recently come to light. These activities are attributed to lipoarabinomannans (LAM) and their precursors lipomannans (LM), two predominant glycolipids of M. tuberculosis cell wall. LM are able to skew anti‐mycobacterial immune responses into un‐protective ones, while LAM evoke immunosupression upon binding to macrophage and dendritic cell receptors specialized in binding to “self” host components. A newly emerging idea implicates plasma membrane rafts in LM and LAM signaling. Depending on acylation patterns, the glycolipids may either directly incorporate into the raft membrane via mannosylphosphatidylinositol anchors or interact with raft‐associated proteins to affect the assembly of receptor signaling complexes. BioEssays 30:943–954, 2008. © 2008 Wiley Periodicals, Inc.
Highly sensitive spectrofluorimetric determination of trace amounts of prulifloxacin using the aluminium(III)–prulifloxacin system
Authors: Yu Fengshan , Liu Weizhou , Chen Fang , Cai Ping 
Published: September 2008

AbstractThe fluorescence of the prulifloxacin (PUFX)–Al(III) system was investigated . Experiments indicated that the fluorescence intensity of prulifloxacin could be greatly enhanced by Al(III) and sensitized by sodium dodecylbenzene sulphonate (SDBS). Accordingly, a sensitive spectrofluorimetric method for the determination of prulifloxacin was established. While excited at 275 nm, the enhanced fluorescence intensity at 412 nm of the system (ΔF) showed a good linear relationship with the concentration of prulifloxacin within the range 4.0 × 10–8–3.0 × 10–6 mol/L. The regression equation was ΔF = 9.83 + 10.8 × 107c (mol/L); the correlation coefficient and detection limit (3σ/k) were 0.99901 and 2.0 × 10–8 mol/L, respectively. The proposed method has been successfully applied to determine prulifloxacin in real pharmaceutical samples. The luminescence mechanism of the system is also discussed in detail. Copyright © 2008 John Wiley & Sons, Ltd.
Disorganization of the Mn4Ca complex of photosystem II by ruthenium red: a thermoluminescence study
Authors: Gauthier Alain , Carpentier Robert 
Published: September 2008

AbstractRuthenium red (RR) is known to be an inhibitor that binds to Ca2+ sites. It releases Ca2+ and Cl− together with the extrinsic polypeptide of 17 kDa associated with the oxygen evolving complex of photosystem II. In this work we used thermoluminescence to study S2/3QB− and S2QA− charge recombination. It is shown that RR produced a deeper inhibition of oxygen evolution compared with the effect of extrinsic polypeptide or Ca2+/Cl− depletion. Even though Mn is not released, the Mn cluster is disorganized by RR and the S1 → S2 transition is inhibited. Copyright © 2008 John Wiley & Sons, Ltd.
Development and validation of an on‐line two‐dimensional reversed‐phase liquid chromatography–tandem mass spectrometry method for the simultaneous determination of prostaglandins E2 and F2α and 13,14‐dihydro‐15‐keto prostaglandin F2α levels in human plasma
Authors: Komaba Junji , Matsuda Dai , Shibakawa Kimio , Nakade Susumu , Hashimoto Yoshitaka , Miyata Yasuyuki , Ogawa Mikio 
Published: September 2008

AbstractWe developed and validated an on‐line reverse‐phase two‐dimensional LC/MS/MS (2D‐LC/MS/MS) system for simultaneous determination of the levels of prostaglandin (PG) E2 as well as PGF2α and its metabolite 13,14‐dihydro‐15‐keto PGF2α (F2α‐M) in human plasma. Analytes were extracted by a three‐step solid‐phase extraction. Samples were then analyzed by on‐line 2D‐LC/MS/MS with electrospray ionization in negative mode. The 2D‐LC system is composed of two reverse‐phase analytical columns with a trapping column linking the two analytical columns. While an acidic buffer was used for both separation dimensions, differing organic solvents were employed for each dimension: methanol for the first and acetonitrile for the second to increase resolving power. The 2D‐LC/MS/MS method was highly selective and sensitive with a significantly lower limit of quantitation (0.5 pg/mL for PGE2 and 2.5 pg/mL for PGF2α and F2α‐M, respectively). Linearity of the 2D‐LC/MS/MS system was demonstrated for the calibration ranges of 0.5–50 pg/mL for PGE2 and 2.5–500 pg/mL for PGF2α and F2α‐M, respectively. Acceptable precision and accuracy were obtained throughout the calibration curve ranges. This highly selective and sensitive method was successfully utilized to determine the endogenous levels of PGE2, PGF2α, and F2α‐M in plasma samples from six (four male and two female) normal volunteers. The mean concentrations for each analyte were 0.755 pg/mL for PGE2, 5.70 pg/mL for PGF2α and 9.48 pg/mL for F2α‐M. Copyright © 2008 John Wiley & Sons, Ltd.
Introducing natural‐convective chilling to food engineering undergraduate freshmen: Case studied assisted by CFD simulation and field visualization
Authors: Rabi J. A. , Cordeiro R. B. , Oliveira A. L. 
Published: September 2008

AbstractA computational fluid dynamics (CFD)‐assisted didactic activity has been applied to Food Engineering freshmen aiming at introducing basic concepts of process modeling and simulation towards the food industry. Evoking natural convection, a relatively simple case study was proposed involving two initially room temperature porous samples (identified as two fruits) that were placed inside a refrigeration chamber. Three different configurations were suggested for placing such warmer samples so that students were asked to order them with respect to their chilling capability, that is, to their ability to chill samples as fast as possible. Freshmen's written answers were collected before CFD was used to simulate and visualize each distinct chilling scenario. Accordingly, a finite‐volume FORTRAN simulator for transport phenomena in domains fully or partially filled up with porous matrix was used to help compare each chilling performance. Among all possible combinations, answer distribution is presented and discussed in the light of freshmen's scholar background as well as based on the way natural convection concepts were introduced. © 2008 Wiley Periodicals, Inc. Comput Appl Eng Educ 17: 34–43, 2009; Published online in Wiley InterScience (www.interscience.wiley.com); DOI 10.1002/cae20161
Teaching application of MATLAB fuzzy logic toolbox to modeling coplanar waveguides
Authors: Übeyli̇ Elif Derya 
Published: September 2008

AbstractAdaptive neuro‐fuzzy inference systems (ANFIS) have recently gained attention as fast and flexible vehicles to microwave modeling, simulation, and optimization. This article presents an initiative to teach the concept of modeling coplanar waveguides (CPWs) in the fuzzy logic toolbox of MATLAB to the electrical engineering students. The approach was based on illustrative applications that highlight the performance of ANFIS in the computation of the parameters of the microwave components. Following a brief description of CPWs, applications of the ANFIS modeling to the CPWs were done by means of a series of MATLAB functions. The author suggests that the use of MATLAB exercises will assist the students in gaining a better understanding of modeling CPWs by the use of ANFIS. © 2008 Wiley Periodicals, Inc. Comput Appl Eng Educ 16: 223–232, 2008; Published online in Wiley InterScience (www.interscience.wiley.com); DOI 10.1002/cae.20166
Digital simulation of the transformation of plane stress
Authors: Lee Wei‐Pin , Chiu Chang‐Hsuan , Hwan Chung‐Li , Ma John 
Published: September 2008

AbstractIn this study, we developed a computer program to simulate the transformation of plane stress by using Visual Basic.NET. We applied the equations of stress transformation to plane stress problems to calculate the stresses with respect to the 1–2 axes, which are rotated counterclockwise through an angle θ about the x–y origin, and showed the visual results on the screen. In addition, we used animation to observe the change of plane stress. This program was then used in teaching courses, such as Mechanics of Materials and Linear Algebra. Use of the software may help students to understand principal stresses, principal axes, Mohr's circle, eigenvalues, eigenvectors, similar matrices, and invariants. © 2008 Wiley Periodicals, Inc. Comput Appl Eng Educ 17: 25–33, 2009; Published online in Wiley InterScience (www.interscience.wiley.com); DOI 10.1002/cae20180
Psychopathy and personality. An investigation of the relationship between the NEO‐Five Factor Inventory (NEO‐FFI) and the Psychopathy Checklist‐Revised (PCL‐R) in a hospitalized sample of male offenders with personality disorder
Authors: Pereira Nedra , Huband Nick , Duggan Conor 
Published: September 2008

AbstractBackground The concept of psychopathy, as measured by the Psychopathy Checklist‐Revised (PCL‐R), has good reliability and validity and there is a small amount of literature relating it to more general personality traits. Such relationships have not, however, been demonstrated across a variety of populations.Aim To examine the relationship between the PCL‐R and the NEO‐Five Factor Inventory (NEO‐FFI) in a sample of men detained in a secure hospital unit because of personality disorder and having been convicted of at least one criminal offence.Method PCL‐R and NEO‐FFI measures were obtained for 100 men as part of a pre‐admission assessment to a specialist personality disorder treatment unit.Results After controlling for Intelligence Quotient (IQ) and scores on the other four NEO‐FFI domains, PCL‐R total scores were significantly negatively correlated with agreeableness (r = −0.36) and neuroticism (r = −0.22). No other correlations with total scores were significant. PCL‐R Factor 1 scores were significantly negatively correlated with agreeableness (r = −0.31) and with neuroticism (r = −0.26) whereas Factor 2 scores were significantly positively correlated with extraversion (r = 0.22) and negatively with agreeableness (r = −0.21).Conclusions Results were in line with findings from previous studies and were explained in part by considering how facets of the NEO‐FFI map onto the concept of psychopathy. Further research is needed to ascertain whether similar relationships also apply among women, and to examine the relationship between psychopathy and specific facets of the five factor model. Copyright © 2008 John Wiley & Sons, Ltd.
Evaluation of a treatment programme for alcohol‐related aggression
Authors: McCulloch Anna , McMurran Mary 
Published: September 2008

AbstractBackground The development of effective treatments for alcohol‐related aggression and violence is important in binge drinking cultures, as in parts of the UK.Aim The aim was to evaluate the progress and experience of 10 participants in Control of Violence for Angry Impulsive Drinkers (COVAID) using a single case methodology.Method Participants completed 10 individual weekly sessions with trained facilitators following the COVAID manual. Change scores on psychometric questionnaires were examined by calculating clinical significance and reliability of change. Self‐reports of alcohol consumption and aggression were examined. Follow‐up data on convictions were collected. Participants were asked their opinions about COVAID.Results Scores on the Alcohol‐Related Aggression Questionnaire (ARAQ) improved for nine participants; change was both clinically significant and reliable in five cases. Nine participants improved on the Controlled Drinking Self‐Efficacy Scale (CDSES), with seven showing clinically significant improvement. Six participants reported a reduction in alcohol consumption from the first to the second half of the programme. At a mean of 29 weeks post‐treatment, none of the participants had been reconvicted for a violent offence. Participants reported finding COVAID useful and interesting.Conclusion Overall, our findings support the possibility that COVAID may assist in reducing alcohol‐related violence and violent offending. Copyright © 2008 John Wiley & Sons, Ltd.
Selective information processing in hypnotic identity delusion: the impact of time of encoding and retrieval
Authors: Cox Rochelle E. , Barnier Amanda J. 
Published: September 2008

AbstractThis experiment indexed the impact of hypnotic identity delusion on information processing. During hypnosis, high and low hypnotizable participants received a suggestion to become a same‐sex friend (with opposite personality characteristics) and listened to a structured story about two characters with opposite personality characteristics. Importantly, half the participants encoded the story before the delusion suggestion and retrieved it after the suggestion, and half encoded the story after the delusion suggestion and retrieved it after cancellation. The majority of highs, but few lows, passed the suggestion and reported a compelling delusion experience. Of particular interest is that whereas lows' processing of the story was not influenced by the delusion suggestion or the time of encoding and retrieval (they recalled more than highs overall, identified with the story character consistent with their actual identity, and showed no selectivity in recall), highs' processing was influenced both by their delusional experience and the time of encoding and retrieval. Highs who encoded the story after the delusion suggestion identified with the character consistent with their suggested identity and retrieved more information about this character. In discussing these findings we consider the role of encoding vs. retrieval processes, the impact of current conceptions of self on information processing, and the relevance of this work to memory and clinical delusions. Copyright © 2008 British Society of Experimental & Clinical Hypnosis. Published by John Wiley & Sons, Ltd.
Phase 2 trial of oxaliplatin plus capecitabine (XELOX) as second‐line therapy for patients with advanced pancreatic cancer
Authors: Xiong Henry Q. , Varadhachary Gauri R. , Blais Joan C. , Hess Kenneth R. , Abbruzzese James L. , Wolff Robert A. 
Published: September 2008

AbstractBACKGROUND.To the authors' knowledge, there is no established second‐line chemotherapy for patients with pancreatic cancer who have received gemcitabine‐based therapy. A phase 2 trial was conducted to explore the efficacy of capecitabine and oxaliplatin (XELOX) in patients with advanced pancreatic cancer previously who were treated with gemcitabine.METHODS.Patients aged ≤65 years who had an Eastern Cooperative Oncology Group (ECOG) performance status (PS) of 0 to 1 received oxaliplatin at a dose of 130 mg/m2 given on Day 1 and capecitabine at a dose of 1000 mg/m2 twice daily for 14 days. For patients aged >65 years or with an ECOG PS of 2, the oxaliplatin dose was 110 mg/m2 on Day 1 and the capecitabine dose was 750 mg/m2 twice daily for 14 days. The treatment was repeated every 3 weeks. Tumor measurements were performed every 9 weeks and the primary study objective was 6‐month overall survival.RESULTS.The study enrolled 41 patients. Of the 39 evaluable patients, 1 patient had a partial response and 10 patients demonstrated stable disease. The Kaplan‐Meier estimate of the overall median survival was 23 weeks (95% confidence interval [95% CI], 17.0‐31.0 weeks). Progression‐free survival was 9.9 weeks (95% CI, 9.6‐14.5 weeks). The 6‐month and 1‐year survival rates were 44% (95% CI, 31%‐62%) and 21% (95% CI, 11%‐38%), respectively. The most common grade 3‐4 nonhematologic toxicity was fatigue (toxicity was graded using the National Cancer Institute Common Toxicity Criteria [version 2.0]).CONCLUSIONS.The combination of capecitabine and oxaliplatin is active in gemcitabine‐pretreated patients with advanced pancreatic cancer, especially in patients with a good PS and those who have responded to first‐line chemotherapy. Cancer 2008. © 2008 American Cancer Society.