bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of Maternal Vitamin D
3
Levels in Shaping Adolescent Vascular Health: Evidence From a Spanish Population‐Based Birth Cohort
Authors: Sangüesa Júlia , Márquez Sandra , Montazeri Parisa , Fochs Silvia , Pey Nuria , Anguita‐Ruiz Augusto , Warembourg Charline , Rouxel Elke , Nawrot Tim , De Boever Patrick , Elen Bart , Clemente Diana B. P. , Casas Maribel , Vrijheid Martine 
Published: February 2025

Background
Low gestational vitamin D levels may increase offspring risk of cardiovascular disease from an early age. Studies investigating the impact on offspring macrovascular function have been inconsistent. Few included pulse wave velocity as an arterial stiffness indicator, and none included measures of microvascularization as an early marker of cardiovascular health. This study explored the association between gestational vitamin D levels and macro‐ and microvascular health across early adolescence.

Methods and Results

We analyzed data from 430 mother–child pairs from a Spanish birth cohort. 25‐hydroxyvitamin D
3
(vitamin D
3
) levels were measured in serum at 13 weeks of pregnancy. At 11 and 15 years we assessed macrovascular parameters, including systolic and diastolic blood pressure (mm Hg) and pulse wave velocity (m/s), and microvascular parameters (central retinal artery/vein equivalent (μm)). We used continuous (in ng/mL) and categorical (deficient <20 ng/mL versus adequate >20 ng/mL) deseasonalized 25(OH)D
3
levels as exposure. Mixed effect and linear regression models were conducted. During their pregnancies, nearly 23% of the mothers had deficient vitamin D
3
levels. We did not find statistically significant associations between pregnancy vitamin D
3
levels and macro‐ and microvascular function markers across adolescence. However, subjects exposed to deficient vitamin D
3
levels showed a nonstatistically significant decrease in pulse wave velocity (
β
=−0.09 [95% CI, −0.19 to 0.01]) compared with those exposed to adequate levels. There was no evidence of a sex interaction.

Conclusions
Our findings show little evidence to support associations between low vitamin D levels during pregnancy and macro‐ or microvascular health parameters through early adolescence.
Protein Drug Targets for Abdominal Aortic Aneurysm and Proteomic Associations Between Modifiable Risk Factors and Abdominal Aortic Aneurysm
Authors: Qi Yao , Jiang Han , Lun Yu , Gang Qingwei , Shen Shikai , Zhang Han , Liu Mingyu , Wang Yixian , Zhang Jian 
Published: February 2025

Background
Abdominal aortic aneurysm (AAA) is a severe aortic disease for which no pharmacological interventions have yet been developed. This investigation focused on identifying protein‐based therapeutic targets and assessing how proteins mediate the interplay between modifiable risk factors and AAA development.

Methods
Causal inferences between plasma proteins and AAA were drawn using 2‐sample Mendelian randomization, followed by comprehensive sensitivity testing, colocalization, and replication efforts. Further analyses included database interrogation, single‐cell RNA data analysis, enrichment analysis, protein–protein interaction networks, and immunohistochemistry to map the tissue‐specific expression of these proteins, their expression within AAA tissues, and their biological roles. Mediation Mendelian randomization was employed to evaluate the mediating effects of AAA‐related proteins on the associations between AAA and 3 risk factors: hypertension, smoking, and obesity.

Results
A total of 43 proteins were identified as having causal links to AAA. Colocalization analysis pinpointed 13 proteins with strong evidence of colocalization with AAA. Of these, the causal involvement of 10 proteins was substantiated by external validation data. Consistent evidence for PCSK9 (proprotein convertase subtilisin/kexin type 9), IL6R (interleukin‐6R), ECM1 (extracellular matrix protein 1), and ANGPTL4 (angiopoietin‐related protein 4) was further validated through tissue immunohistochemistry and blood data. Moreover, Mendelian randomization analysis identified 10 proteins as mediators of the influence of hypertension, smoking, and obesity on AAA development.

Conclusions
This analysis identifies 4 proteins (PCSK9, IL6R, ECM1, and ANGPTL4) as high‐priority therapeutic targets for AAA and emphasizes the intermediary role of plasma proteins in linking hypertension, smoking, obesity, and AAA. Further investigations are needed to clarify the specific roles of these proteins in AAA pathology.
Predictive Effect of Atypical Right Bundle‐Branch Block on In‐Hospital Sudden Cardiac Death and Cardiac Rupture and Long‐Term Prognosis in Patients With Acute Myocardial Infarction Who Underwent Percutaneous Coronary Intervention
Authors: Yang Tiangui , Chen Jie , Fu Xi , Xu Changlu , Liu Xiaoxia , Fu Peng , Niu Tiesheng 
Published: February 2025

Background
A study was conducted to explore the predictive effect of atypical right bundle‐branch blocks (ARBBB) on in‐hospital sudden cardiac death (SCD), cardiac rupture (CR), and long‐term prognosis in patients with acute myocardial infarction undergoing percutaneous coronary intervention with a drug‐eluting stent.

Methods and Results

A total of 13 886 patients with first‐episode acute myocardial infarction who underwent percutaneous coronary intervention with a drug‐eluting stent at 3 centers from January 2017 to January 2022 were included in this retrospective study. Patients were categorized into 4 groups: ARBBB (n=348), typical right BBB (n=374), left BBB (n=366), and non‐BBB (n=12 798). The primary end points were in‐hospital SCD and CR, the secondary end points were 2‐year major adverse cardiovascular and cerebrovascular events. During the in‐hospital observation period, 334 patients (2.4%) experienced SCD, with 98 (0.7%) attributed to CR. The incidences of in‐hospital SCD and CR in the group with ARBBB were significantly higher than those in the other 3 groups (ARBBB versus left BBB versus typical right BBB versus non‐BBB: SCD, 10.6% versus 5.7% versus 4.3% versus 2.0%,
P
=0.001; CR, 5.7% versus 2.7% versus 1.3% versus 0.5%,
P
<0.001). ARBBB was a statistically significant predictor of in‐hospital SCD (hazard ratio [HR], 2.45 [95% CI, 1.65–4.78],
P<
0.001) and CR (HR, 3.32 [95% CI, 1.77–7.74],
P<
0.001). ARBBB could also predicted the 2‐year major adverse cardiovascular and cerebrovascular events (HR, 2.99 [95% CI, 1.65–5.53],
P<
0.001).

Conclusions
ARBBB is a predictor of in‐hospital SCD, CR, and 2‐year major adverse cardiovascular and cerebrovascular events in patients with first‐episode acute myocardial infarction undergoing percutaneous coronary intervention with a drug‐eluting stent.
Effects of Glucagon‐Like Peptide‐1 Receptor Agonists, Sodium‐Glucose Cotransporter‐2 Inhibitors, and Their Combination on Neurohumoral and Mitochondrial Activation in Patients With Diabetes
Authors: Ikonomidis Ignatios , Pavlidis George , Pliouta Loukia , Katogiannis Konstantinos , Maratou Eirini , Thymis John , Michalopoulou Eleni , Prentza Vasiliki , Katsanaki Eleni , Vlachomitros Dimitrios , Kountouri Aikaterini , Korakas Emmanouil , Andreadou Ioanna , Kouretas Dimitrios , Parissis John , Lambadiari Vaia 
Published: February 2025

Background
We investigated the effects of the combined treatment with glucagon like peptide‐1 receptor agonists (GLP‐1RA) and sodium‐glucose cotransporter‐2 inhibitors (SGLT‐2i) on NT‐proBNP (N‐terminal pro‐brain natriuretic peptide), GDF‐15 (growth differentiation factor 15), and MOTS‐c (mitochondrial‐derived peptide‐c) in patients with type 2 diabetes (T2D) and high or very high cardiovascular risk.

Methods
We studied 163 consecutive patients with type 2 diabetes who were treated with insulin (n=40), liraglutide (n=41), empagliflozin (n=42), or their combination (GLP‐1RA+SGLT‐2i) (n=40) and were matched using propensity score analysis. We measured the following at baseline and 4 and 12 months of treatment: (1) NT‐proBNP, GDF‐15, and MOTS‐c; (2) 2,2′‐azino‐bis(3‐ethylbenzothiazoline‐6‐sulfonic acid), and (3) left ventricular global longitudinal strain, left atrial strain during atrial reservoir phase, and global work index using speckle‐tracking imaging.

Results

At 12 months, GLP‐1RA, SGLT‐2i, and their combination showed a greater reduction of NT‐proBNP (−43.1% versus −54.2% versus −56.9% versus −14.7%) and GDF‐15 than insulin. Only treatment with SGLT‐2i and GLP‐1RA+SGLT‐2i improved MOTS‐c. GLP‐1RA, SGLT‐2i, or GLP‐1RA+SGLT‐2i provided an increase of global longitudinal strain, left atrial strain, and global work index compared with insulin. In all patients, the reduction of NT‐proBNP was associated with the improvement of global longitudinal strain, left atrial strain during atrial reservoir phase, and global work index; the decrease of GDF‐15 with the increase of ABTS and MOTS‐c; and the increase of MOTs‐c with improved global longitudinal strain and constructive myocardial work at 12 months (
P
<0.05).

Conclusions
Twelve‐month treatment with combination of GLP‐1RA+SGLT‐2i was associated with a greater reduction of neurohumoral markers and increase of antioxidant ability than each treatment alone and insulin. SGLT‐2i appear more effective in the improvement of neurohumoral and mitochondrial activation.

Registration

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT03878706.
Living in the dark side? Plastic activity in the Bothrops jararaca group (Serpentes, Viperidae)
Authors: Banci Karina R.S. , Eterovic André , Rosa Luana G.S. , Marques Otavio A.V. 
Published: February 2025

Abstract
The activity of snakes is affected by several ecological factors, being light-dark cycle the most important of them. Bothrops alcatraz and B. jararaca are nocturnal in situ. However, the critically endangered Golden Lancehead, B. insularis, was described as diurnal in Queimada Grande Island, where adults rely mainly on migratory, diurnal birds preyed when they are active. Herein, we present comparative data on the activity of these representatives of the Bothrops jararaca group, testing the following hypotheses: (1) B. alcatraz and B. jararaca are nocturnal even in captivity, and (2) B. insularis is also nocturnal in the absence of birds. Data on the activity of these pitvipers in captivity were obtained using closed circuit television. Daily activity of captive B. insularis was compared to that from the island, where its seasonal pattern was also investigated. Our results show that all three species are intrinsically nocturnal but B. insularis hunts during the day in the wild, being more active in the dry season. We also show that B. jararaca extends its activity through daytime in colder periods. Caudal luring was displayed by all species in captivity, mostly at night in B. alcatraz and B. jararaca, and during the day in B. insularis, even though such differences were not always significant. In summary, we demonstrate that activity may be plastic and influenced by other biotic and abiotic variables apart from the light-dark cycle.
The complete mitochondrial genome of Glyphocrangon regalis (Caridea, Glyphocrangonidae) and the phylogenetic relationships of Caridea
Authors: Chen Jian , Sun Yuman , Li Jiji , Xu Kaida , Ye Yingying 
Published: February 2025

Abstract
In studying the mitochondrial genome (mitogenome) composition and gene sequences of deep-sea organisms, it is of great importance to understand and explore the molecular mechanisms underlying their adaptation to the deep-sea environment. Glyphocrangon regalis belongs to Caridea, Crangonoidea, and is a typical deep-sea shrimp. In this study, the complete mitogenome of G. regalis was obtained using next-generation sequencing technology. The mitochondrial genes were annotated, and their sequence structures were analysed. The complete mitogenome sequence of G. regalis was 15 918 bp in length, with a base composition of A (36.85%), T (36.68%), C (15.53%) and G (9.94%), exhibiting a significant AT bias with an A + T content of 75.53%. G. regalis encoded a total of 37 genes, including 13 protein-coding genes (PCGs), 22 tRNAs and 2 rRNAs; among them, 14 genes were located on the negative strand, and 23 genes were located on the positive strand, similar to other caridean shrimp mitogenomes. Additionally, a phylogenetic tree was constructed based on the 13 PCGs of the mitogenomes of 95 species from 12 families within Caridea, supporting the monophyly of various families within Caridea and revealing that G. regalis and species of Pandalidae were the most closely related. This study provides insights into the complete mitogenome of G. regalis, elucidating its genomic characteristics and structural functions. It clarifies the evolutionary status of G. regalis and explores the evolutionary patterns of various families within Caridea through phylogenetic tree construction, thereby providing more references for the study of Caridea systematics.
Parametataeniacanthus pseudorhombi gen. et sp. nov. (Copepoda, Cyclopoida, Taeniacanthidae), recovered from Japanese fishes (Actinopterygii)
Authors: Izawa Kunihiko 
Published: February 2025

Abstract
Parametataeniacanthus pseudorhombi gen. et sp. nov. is described based on specimens of the female recovered from the bucco-branchial cavity of the cinnamon flounder, Pseudorhombus cinnamoneus (Temminck & Schlegel, 1846) (Pleuronectiformes, Paralichthyidae) in Japan.
Cosmology and Meontology: Continental Philosophy and Saint Paul
Authors: van der Heiden Gert-Jan 
Published: February 2025

Abstract
The philosophical turn to the letters of Saint Paul in the 1990s can also be read as a critical assessment of the concept of κόσμος, especially in the philosophical sense of order. In this article, it is shown that especially the so-called “meontological passages” to which philosophers such as Heidegger, Agamben, Badiou and Taubes equally turn, can be read in terms of such a critical assessment. The article opens with exploring the stakes of present-day philosophical interpretations of Saint Paul, namely to move beyond onto-theology towards meontology. Subsequently, it is argued why the meontological emphasis of these interpretations are neither crypto-Marcionite nor nihilistic. Finally, an in-depth reading of two meontological passages is offered showing how an interpretation organized around the concepts of κατάργησις and χρῆσις indeed lives up to the stakes of the present-day philosophical interest in Paul’s letters.
Worldlessness of Artificial Intelligence
Authors: Ziarek Płonowska 
Published: February 2025

Abstract
The concept of an ontology of digital worldlessness developed in this essay examines how the unequal distribution of the ecological, political, and economic harms of AI undermines plural political belonging in a common world. It argues that digital worldlessness stems from a constellation of several sociopolitical practices, including: a) the formalization of information inherent in algorithmic procedures abstracted from the material world, history, and common sense; b) the insertion of digital surveillance networks into a common world to facilitate continuous extraction of data; c) the opacity of algorithmic procedures to the general public affected by their outcomes; and d) the algorithmic sorting of people and nonhuman phenomena in relation to prediction targets set by corporations and state institutions. Drawing on Hannah Arendt’s political theory and on critical race and feminist theories of AI, in particular, Ruha Benjamin and Wendy Chun, the essay foregrounds the relationship between world, technology and power in order to analyze the assaults on human plurality by algorithmic practices. These practices not only automate gender, racist and economic discrimination, but also undermine collective action contesting these harms.
This approach to digital ontology provides an alternative to the dominant but narrow technical meaning of computational ontology in analytical philosophies and computer sciences where this term refers to formulating compatible taxonomies among different data sets for the purposes of information classification.
Resurgence of Diplomatic Asylum in International Law: Human Rights the Missing Piece of Puzzle
Authors: Alexander Atul 
Published: February 2025

Abstract
This study evinces that current legal practice does not favour the grant of diplomatic asylum. However, the right to diplomatic asylum is not sufficiently addressed from an individual or human rights lens. Instead, it is conceived as an object of the States exercising its right. In recent years, the courts have widened the scope of human rights to endorse its extraterritorial application, thereby influencing the right to diplomatic asylum. However, this contradicts the provisions of the Vienna Convention on Diplomatic Relations and general international law since granting diplomatic asylum is not a diplomatic function and impinges on state sovereignty. Previous literature on the topic bespeaks the sliding scale and conciliatory approaches in accommodating human rights. The author argues that human rights should be regarded as a valid ground for granting diplomatic asylum. It is concluded that this proposition can challenge the statist approach to diplomatic asylum.
Evaluation of innovative insect-based products by Portuguese consumers using a repeated exposure approach under a controlled setting
Authors: Barbosa B. , Rocha C. , Ribeiro J.C. , Lima R.C. , Costa A.I.A. , Monteiro M.J.P. , Maya C. , Roos N. , Cunha L.M. 
Published: February 2025

Abstract
In an era of considerable environmental pressures, edible insects have demonstrated their ability to integrate innovative and sustainable food production methods. Nonetheless, there are clear obstacles to their acceptance, particularly in Western countries. With a view to a longitudinal analysis of the consumption moment, the study’s main goal was to assess how the repeated exposure approach can impact consumer’s liking and sensory perception of different insect-based products. At the same time, these products were compared with commercially available plant-based analogue products, as these types of products can be targeted to the same market. For each group of products, the impact of repeated exposure on participants exposed to the products in a household context was compared with a group of participants who had no intervention at home. This comparative assessment was carried out in a sensory laboratory environment. Five different insect and plant-based products were assessed on a 9-point hedonic scale with open comments to complement the analysis by two panels of 58 participants. Significant differences were found between products throughout the exposure, with most products decreasing the liking scores between exposures. However, no significant differences concerning exposure were identified between the intervention and non-intervention groups. Regarding the evaluation of the samples according to the different exposure groups, it was observed that there was no noticeable impact of exposure on the evaluation of the insect-based products evaluated by the intervention group and the plant-based products tasted by the non-intervention group. This study reinforces the impact of repeated exposure on the overall liking levels of the samples, with valuable findings on sensory perception that can be translated into insect-based product development.
Emigrant Literature, World Literature, National Literature
Authors: Frank Søren 
Published: February 2025

Abstract
This article examines Georg Brandes’ comparative method and notions of emigrant literature, world literature, and national literature, comparing them to Goethe’s and Milan Kundera’s ideas of world literature, and drawing on Emily Apter’s concept of untranslatability. It is argued that Brandes, like Apter, valorizes an untranslatable dimension of language in his paradoxical notion of world literature as the most national literature, whereas Goethe and Kundera consider translations to be unproblematic as a result of their belief in linguistic transparency. Where Goethe accentuated cultural similarities and universalism, Brandes was keen to stress cultural differences. His cosmopolitanism was firmly rooted in the local, national, and regional. The article further argues that Goethe’s concept of Weltliteratur was centered on a theory of circulation and infrastructure. In contrast, both Brandes and Kundera placed emphasis on intra-literary qualities, Brandes primarily linguistic qualities, Kundera more specifically existential and formal newness. Each of the three positions has its merits and supplement each other. Together, they provide us with an understanding of the significance of the field of world literature as both an aesthetic and sociological phenomenon.
Poetic Migrations within Socialist Yugoslavia and the Non-Aligned Movement
Authors: Živković Yvonne 
Published: February 2025

Abstract
This article analyzes the Yugoslav poetry festival, The Poetry Evenings in Struga, Macedonia as a catalyst of transnational poetry exchanges on the fringes of Europe between 1961 and 1990. It examines to what extent the organizers, the participating poets and the literary output generated by the festival (anthologies, journals, translations etc.) contributed to the promotion of poetry as world literature. By evoking a migratory poetics through various means and practices, the festival intended to further transnational solidarity as one of the central tenets of the Non-Aligned Movement. The three crucial elements of this migratory poetics were: 1) the subversion of spatial and political categories of the time, specifically those of an eastern and western bloc, invoking an ideal of poetry that was constantly oscillating between the local and the global, and which particularly recognized those marginalized within the dominant political power dynamic; 2) the promotion of multilingualism and translation, particularly from and into minor languages (the festival’s main languages were Macedonian and Serbo-Croatian) and 3) the invitation and recognition of authors who were either internally or geographically displaced from their countries of origin due to their non-conformist and dissident views.
وثيقة بيع وشراء ثلاث إماء مدونة
Authors: فقعس أحمد 
Published: February 2025

الملخص
‫تتناول الدراسة بالشرح والتحليل وثيقة بيع وشراء ثلاث إماء، مدونة في أحد النقوش الخشبية المحفوظة في المتحف الحربي بصنعاء، ولا تكمن أهمية النقش في محتواه اللغوي المشتمل على عددٍ من المفردات الجديدة ولا في موضوعه الاجتماعي المهم الذي يسلط الضوء على إحدى المعاملات اليومية التي مارسها اليمنيون قديمًا فحسب، وإنما أيضًا لأنهُ يُعد من أطول النقوش الخشبية المكتشفة حتى اللحظة وأكبرها حجمًا.‬
هينة بنت وهب، امرأة نبطية حِجْرية من القرن الأول الميلادي
Authors: الفاسي هتون أجواد 
Published: February 2025

ملخص
‫يبلغ عدد مقابر الحِجر/ مدائن صالح (محافظة العلا) التي تحمل كتابات ضريحية والتي تم الكشف عنها حتى الآن 36 مقبرة نبطية تحمل 39 نقشًا، حيث إن 33 منها مؤرخة بين العام الأول قبل الحقبة العامة (ق.م.) والعام 74 من الحقبة العامة (الميلادي)، وسبع من هذه المقابر تعود ملكيتها لنساء وثلاث أخرى تملكها نسوة مع رجال. إحدى هذه المقابر التي لم تمس نظرًا لانسداد مدخلها، تعود إلى هينة بنت وهب التي توفيت عام 60/61م وتركت نصًا (JS26) تحدد فيه من هم ورثتها ومن لهم الحق في الدفن في هذه المقبرة. وفي عام 2008 دخلت المقبرة في تنقيبات “المشروع السعودي-الفرنسي للآثار” (2002–2022) والذي قدم معلومات مهمة عن الأنباط والمرأة النبطية وعادات الدفن. وهي المقبرة الوحيدة التي تملكها امرأة تم التنقيب فيها حتى الآن. وتسعى هذه الورقة، من جانب، إلى الربط بين النص الضريحي والكشف الأثري، ومن جانب آخر، إلى عقد المقارنة وتحليل أبعاد هذه العلاقة اجتماعيًا، واقتصاديًا، وسياسيًا ودينيًا، بناء على الدراسات اللغوية والتاريخية والأثرية. وتقع في سياق محاولتنا الحثيثة لفهم مكانة المرأة في المجتمع النبطي خاصة والعربي قبل الإسلام عامة.‬