bluuebunny/crossref_metadata_2025_split huggingface dataset:
Künstliche organische Hochpolymere, VII. Mitteil.: Zur Kenntnis neuer Acrylderivate und ihrer Polymerisate
Authors: Lieser Th. , Kemmner Karl 
Published: May 2007

AbstractEs wird die Anlagerung von Acrylnitril an Glykole (bzw. Schwefelwasserstoff) zu Bis‐[β‐cyan‐äthyl]‐glykoläthern bzw. Bis‐[β‐cyan‐äthyl]‐sulfiden und die Kondensation der Anlagerungsprodukte mit Hydrazin zu Poly‐aminotriazolen beschrieben. Aus Methacrylsäure und Hydrazin bzw. Phenylhydrazin wurden 4‐Methyl‐pyrazolidon‐(3) bzw. 4‐Methyl‐1‐phenyl‐pyrazolidon‐(3) bzw.‐(5) erhalten. Es wurden ferner Acryl‐, Methacryl‐ und α‐Chloracryl‐isocyanat hergestellt und zahlreiche Anlagerungsreaktionen derselben an ein‐ und zweiwertige Verbindungen und Polymerisationsreaktionen untersucht.
Oxydationsgeschwindigkeiten von Endiolen
Authors: Arndt Fritz , Loewe Lotte , Ayça Ertugrul 
Published: May 2007

AbstractDie Geschwindigkeiten der Oxydation von Ascorbinsäure, Redukton, Cumarindiol, Thiacumarindiol und Carbostyrildiol durch Tillmans Reagens, Eisen(III)‐Salz und Jod unter verschiedenen Bedingungen werden verglichen und die Kinetik dieser Reaktionen sowie ihr Zusammenhang mit der Konstitution der untersuchten Endiole erörtert.
Kondensationen von Allyl‐ und Cinnamyl‐pyridinium‐Salzen mit Aldehyden
Authors: Kröhnke Fritz , Jentzsch Gertraude 
Published: May 2007

AbstractWie Benzyl‐pyridinium‐Salze lassen sich auch Allyl‐und Cinnamyl‐pyridinium‐Salze mittels Essigsäureanhydrids und Kaliumacetats in guter Ausbeute, etwas weniger günstig Cinnamyl‐isochinolinium‐Salze, mit Aldehyden zu subst. Vinyl‐pyridinium‐Salzen kondensieren. In einigen Fällen bleibt die Reaktion bei der Stufe des acetylierten Pyridinium‐äthanols stehen.
Zur Kenntnis des Verhaltens von Nichtmetallchalkogeniden gegenüber flüssigem Ammoniak, VIII. Über Reaktionen der Sulfide des Siliciums, Germaniums und Zinns im Ammonosystem
Authors: Behrens Helmut , Ostermeier Johann 
Published: May 2007

AbstractBei der Umsetzung von SiS2 mit flüssigem Ammoniak bei − 33° lassen sich unter verschiedenen Bedingungen die Verbindungen SiNH(SNH4)2, SiS(NH2)2 und SiSNH nachweisen. — Während GeS mit flüss. Ammoniak nicht reagiert, löst sich GeS2 unter Bildung von NH4[GeS2NH2]. Mit (NH4)2S bildet GeS2 im Ammonosystem (NH4)2[GeS3], das, wie auch NH4[GeS2NH2], gemäß
equation image
Unter Abgabe von NH3 und H2S in GeS2 übergeht. Mit KNH2 bildet eine Lösung von GeS2 in flüss. Ammoniak in einer neutralisationsanalogen Reaktion schwerlösliches K2[GeS2NH]. Das in flüss. Ammoniak unlösliche SnS2 setzt sich mit (NH4)2S zu (NH4)4[SnS4] und (NH4)2[SnS3] um, die beide oberhalb von 100° SnS2 zurückbilden. — GeS und SnS werden durch (NH4)2S in flüss. Ammoniak unter H2‐Entwicklung oxydiert:
equation image
.
Specifically Immobilised Aldo/Keto Reductase AKR1A1 Shows a Dramatic Increase in Activity Relative to the Randomly Immobilised Enzyme
Authors: Holland‐Nell Kai , Beck‐Sickinger Annette G. 
Published: May 2007

AbstractThe difference between site‐specific and random immobilisation of the aldo/keto reductase AKR1A1 was explored. AKR1A1 was recombinantly expressed as a thioester by the intein strategy. The thioester was selectively modified with a biotin label by the expressed protein ligation method, and subsequent immobilisation on streptavidin templates was performed. Adsorption of wild‐type AKR1A1 to streptavidin templates and of biotinylated AKR1A1 to uncoated templates was used to study randomly immobilised enzymes. Investigation of the kinetic parameters revealed remarkably improved activity for the site‐specifically immobilised enzyme, which was comparable to that of the wild‐type enzyme in solution and 60–300‐fold greater than that of the randomly immobilized enzymes. Furthermore, the enzyme was surprisingly stable. No loss of activity was observed for over a week, and even after 50 days more than 35 % of activity was maintained.
CYP3A4 Activity in the Presence of Organic Cosolvents, Ionic Liquids, or Water‐Immiscible Organic Solvents
Authors: Chefson Amandine , Auclair Karine 
Published: May 2007

AbstractP450 enzymes have attracted the attention of chemists for decades because of their impressive ability to catalyze the hydroxylation of inactivated CH bonds. However, their use for synthesis in aqueous systems is limited. We report here a survey of the activity of purified human CYP3A4 in the presence of organic solvents or ionic liquids. We show that CYP3A4 tolerates only small amounts (<15 %) of water‐miscible organic cosolvents or ionic liquids before its activity toward testosterone drops below detection. [BMIM][PF6] in a biphasic system was less detrimental to enzyme activity, with 20 % of the activity remaining in the presence of 15 % of this ionic liquid. CYP3A4 activity in the absence of buffer was only ≥10 % in solvents of the alkane series, with a minimum of 0.85 % water, and with the addition of sucrose and testosterone before enzyme lyophilization. Biphasic solvent systems were more promising, with ∼85 % of the activity retained.
Electrostatic Attachment of Gold and Poly(lactic acid) Nanoparticles onto ω‐Aminoalkanoic Acid Self‐Assembled Monolayers on 316L Stainless Steel
Authors: Shustak Galit , Shaulov Yulia , Domb Abraham J. , Mandler Daniel 
Published: May 2007

AbstractThe assembly of poly(lactic acid) (PLA) nanoparticles on a 12‐aminodecanoic acid (ADA) self‐assembled monolayer (SAM) is described. Assembly is accomplished through electrostatic interactions between the positively charged SAM and the negatively charged PLA nanoparticles. The strategy used involves two steps in which a preliminary electrochemical coating of the ADA SAM is followed by a second step that involves immersing the SAM in a solution containing gold or PLA nanoparticles. The SAM was characterized by using cyclic voltammetry (CV), X‐ray photoelectron spectroscopy (XPS), FTIR spectroscopy, and contact angle measurements, whereas scanning electron microscopy (SEM) was used to image the nanoparticles after electrostatic attachment was achieved. We found that the surface coverage of the nanoparticles could be controlled by modulating the electrostatic interactions between the negatively charged particles and the positively charged SAM surface by varying the pH of the nanoparticle solution, the immersion time, and the number of cyclic voltammetry scans under which the SAM was formed.
Towards Nanotubular Structures with Large Voids: Dynamic Heteroleptic Oligophenanthroline Metallonanoscaffolds and their Solution‐State Properties
Authors: Schmittel Michael , Kalsani Venkateshwarlu , Michel Christoph , Mal Prasenjit , Ammon Horst , Jäckel Frank , Rabe Jürgen P. 
Published: May 2007

AbstractThe assembly of a rigid macrocycle with two exotopic phenanthroline binding sites in combination with linear bis‐ or trisphenanthrolines and copper(I) ions is used to generate nanoscale double and triple deckers, the latter showing a tubular structure. With supramolecular chemistry expanding to dynamic, large cavity, nanoscale structures, it becomes increasingly important to use robust assembly protocols as well as reliable characterization techniques. To fully elucidate and to describe the dynamic nature of metallonanoscaffolds with large voids, we applied a battery of both direct and indirect solution‐state characterization methods. These methods along with the conventional direct methods provide a very useful tool for characterizing tubular nanoscaffold aggregates.
Sugar‐Assisted Ligation for the Synthesis of Glycopeptides
Authors: Brik Ashraf , Wong Chi‐Huey 
Published: May 2007

AbstractChemical synthesis of glycoproteins from readily available materials is a powerful method for obtaining a pure product with full control of its atomic structure. Sugar‐assisted ligation (SAL) is an emerging approach that allows the synthesis of a large glycopeptide from two unprotected fragments. Contrary to other ligation methods that are limited to the use of a cysteine residue or depend on external auxiliary, SAL takes advantage of the existing sugars in glycopeptides to promote proximity between the two peptides to facilitate an amide bond formation.
New, Chiral Phase Transfer Catalysts for Effecting Asymmetric Conjugate Additions of α‐Alkyl‐α‐cyanoacetates to Acetylenic Esters.
Authors: Wang Xisheng , Kitamura Masanori , Maruoka Keiji 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Metal(II) Schiff Base Complexes as Catalysts for the High‐Regioselective Conversion of Epoxides to β‐Hydroxy Nitriles in Glycol Solvents.
Authors: Naeimi Hossein , Moradian Mohsen 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
In situ Preparation of Rhodium/N‐Heterocyclic Carbene Complexes and Use for Addition of Arylboronic Acids to Aldehydes.
Authors: Kilincarslan Rafet , Yigit Murat , Oezdemir Ismail , Cetinkaya Engir , Cetinkaya Bekir 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Bond Orders and Atomic Properties of the Highly Deformed Halogenated Fullerenes C60F18 and C60Cl30 Derived from Their Charge Densities.
Authors: Huebschle Christian B. , Scheins Stephan , Weber Manuela , Luger Peter , Wagner Armin , Koritsansuky Tibor , Troyanov Sergey I. , Boltalina Olga V. , Goldt Il'ya V. 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Chiral Dumbbell Shaped Bis(fullerene) Oligoelectrolyte
Authors: Chronakis Nikos , Hartnagel Uwe , Braun Martin , Hirsch Andreas 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Oxidative Cyclization Reaction of Dibenzylbutanolides with Combined Utilization of Synthetic Chemistry and Biotechnological Methods.
Authors: Takemoto Masumi , Hongo Yoko , Aoshima Youichi , Kutney James Peter 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Enantioselective Friedel—Crafts Reaction of Electron‐Rich Alkenes Catalyzed by Chiral Broensted Acid.
Authors: Terada Masahiro , Sorimachi Keiichi 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of 1,4‐Disubstituted 1,2,3‐Triazoles via a Three‐Component Reaction in Water in the Presence of CuX (X: Cl, I).
Authors: Wang Zhong‐Xia , Zhao Zhi‐Gang 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Cu(OTf)2 Catalyzed High Yield Synthesis of Hantzsch 1,4‐Dihydropyridines.
Authors: Paraskar Abhimanyu S. , Sudalai Arumugam 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
New Reaction of Schiff Base with Dimedone: New Method for the Acridine Derivatives under Microwave Irradiation.
Authors: Tu Shujiang , et al. et al. 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Reactions of 8‐(Triphenylphosphoimino)quinoline (III) with Aryl Aldehydes and Aryl Isocyanates: Formation of 2‐Aryl‐4H‐imidazo[4,5,1‐ij]quinolines and Related Systems.
Authors: Nagamatsu Kentaro , Akiyoshi Erina , Ito Hidenori , Fujii Hiroyuki , Kakehi Akikazu , Abe Noritaka 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Isothiazolo‐Fused Quinoline Analogues: Synthesis of Isothiazolo[5,4‐b]quinolines and Their Oxidation Products, 3[2H]‐One‐1,1‐dioxideisothiazolo[5,4‐b]quinolines from 2‐Chloro‐3‐formylquinolines.
Authors: Srivastava A. , Chandra Atish , Singh R. M. 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of N1, N3‐Free Pyrimidine Bridged Polycyclic Compounds via Photo‐Diels—Alder Reaction of N,N‐Diacetyl‐5‐fluorouracil with Naphthalenes.
Authors: Ohkura Kazue , Ishihara Tetsuya , Nishijima Ken‐ichi , Diakur James M. , Seki Koh‐ichi 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of Novel Di‐ and Trisaccharide Mimetics with Non‐Glycosidic Amino Bridges.
Authors: Neumann Janna , Weingarten Saskia , Thiem Joachim 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Novel Chiral Synthetic Path to Indolizidine and Quinolizidine Alkaloids by Means of a Samarium Diiodide‐Promoted Reductive Carbon‐Nitrogen Cleavage Reaction: Synthesis of (+)‐(8R, 8aR)‐Perhydro‐8‐indolizidinol (V) and (‐)‐Deoxynupharidine (XVIII).
Authors: Katoh Miho , Mizutani Hirotake , Honda Toshio 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Salzhydrate als Latentwärmespeicher
Authors: Lindemann Helmut , Ritter Stefan , Schmidkunz Heinz 
Published: May 2007

AbstractDIE BERECHTIGTE FORDERUNG nach Einsparung von Energie ist stets gekoppelt mit dem Suchen nach passenden Systemen, die Latentenergie speichern können. Unter Latentenergie versteht man Wärme‐ oder Lichtenergie (elektromagnetische Felder), die sich normalerweise einer Speicherung entziehen und somit verloren sind. Es ist deshalb Absicht, solche Energien in Form von chemischer Energie zu speichern.
Synthesis and Evaluation of 3‐Phenylpyrazolo[3,4‐d]pyrimidine‐Peptide Conjugates as Src Kinase Inhibitors
Authors: Kumar Anil , Wang Yuehao , Lin Xiaofeng , Sun Gongqin , Parang Keykavous 
Published: May 2007

Abstract3‐Phenylpyrazolo[3,4‐d]pyrimidine (PhPP) derivatives substituted with an alkyl or aryl carboxylic acid at the N1‐endocyclic amine, such as PhPP‐CH2COOH (IC50=250 μM), and peptides Ac‐CIYKYY (IC50=400 μM) and Ac‐YIYGSFK (IC50=570 μM) were weak inhibitors of polyE4Y phosphorylation by active c‐Src. A series of PhPP–peptide conjugates were synthesized using PhPP as an ATP mimic and CIYKYY or YIYGSFK as a peptide substrate to improve the inhibitory potency against active c‐Src kinase. PhPP derivatives were attached to the N terminus or the side chain of amino acids in the peptide template. Two N‐terminal substituted conjugates, PhPP‐CH2CO‐CIYKYY (IC50=0.38 μM) and PhPP‐CH2CO‐YIYGSFK (IC50=2.7 μM), inhibited the polyE4Y phosphorylation by active c‐Src significantly higher than that of the parent compounds. The conjugation of PhPP with the peptides produced a synergistic inhibition effect possibly through creation of favorable interactions between the conjugate and the kinase domain as shown by molecular modeling studies.
The impact of chronic illnesses on the use and effectiveness of adjuvant chemotherapy for colon cancer
Authors: Gross Cary P. , McAvay Gail J. , Guo Zhenchao , Tinetti Mary E. 
Published: May 2007

AbstractBACKGROUND.It is unclear how noncancer conditions affect the use or effectiveness of adjuvant therapy among older patients with colon cancer.METHODS.The authors conducted a cohort study of older patients with stage III colon cancer who were diagnosed from 1993 to 1999 in the Surveillance, Epidemiology, and End Results‐Medicare database. The correlations between receipt of adjuvant chemotherapy and heart failure, diabetes, and chronic obstructive pulmonary disease (COPD) were assessed. Multivariable regression analysis was used to assess the risk of death and hospitalization as a function of treatment and comorbidity status.RESULTS.The study sample consisted of 5330 patients (median age, 76 years). The use of adjuvant therapy was related significantly to heart failure (36.2% vs 64.9% of patients with vs without heart failure, respectively; adjusted odds ratio [OR], 0.49; 95% confidence interval [95% CI], 0.40–0.60). More moderate correlations were observed for COPD (OR, 0.83; 95% CI, 0.70–0.99) and diabetes (OR, 0.81; 95% CI, 0.68–0.97). Among patients who had heart failure, the 5‐year survival was significantly higher among those who received adjuvant chemotherapy (adjusted 5‐year survival rate, 43%; 95% CI, 40–47%) than among those who did not receive adjuvant chemotherapy (30%; 95% CI, 27–34%). Among patients without heart failure, the 5‐year survival estimates among treated and untreated patients were 54% (95% CI, 52–56%) and 41% (95% CI, 38–44%), respectively. The probability of all‐cause, condition‐specific, or toxicity‐related hospitalization associated with adjuvant therapy was not altered by the presence of any of the 3 conditions.CONCLUSIONS.Although chronic conditions appeared to be a strong barrier to the receipt of adjuvant chemotherapy, adjuvant therapy appeared to provide a significant survival benefit to patients who had colon cancer with the conditions studied. Cancer 2007. © 2007 American Cancer Society.
The treatment of sexually dysfunctional women without partners: A controlled study of three behavioural group approaches
Authors: Stravynski Ariel , Gaudette Gilles , Lesage Alain , Arbel Nira , Bounader Jocelyne , Lachance Lise , Clerc Doris , Fabian Jose , Lamontagne Yves , Langlois Robert , Lipp Olivier , Sidoun Paul 
Published: May 2007

AbstractBackground. In the absence of models of therapy for sexual dysfunction in single women, this study drew on approaches that have been shown to be useful with men. This controlled study compared three approaches to the treatment of sexually dysfunctional single women.Method. Forty‐nine sexually dysfunctional women were randomly assigned to treatments focusing on either their sexual dysfunction, their interpersonal problems, a combination of both or a waiting list; 47 completed treatment, and 45 a 1 year follow‐up. Treatment was administered in small groups in 15 weekly sessions and four 6 weekly sessions during the first 6 months of a 1 year follow‐up.Results. No clinically meaningful change was observed during the waiting period. In contrast, a significant and equivalent improvement was observed in all treatment conditions by the end of treatment and was maintained at 6 and 12 month follow‐ups. No significant differences between the treatment conditions were found at any point.Conclusions. Sexual dysfunction in single women responded to treatment by various behavioural group approaches. Clinically, results fell short of the improvements observed in sexually dysfunctional men treated similarly. Copyright © 2007 John Wiley & Sons, Ltd.
Who can benefit from time‐limited dynamic psychotherapy? A study of psychiatric outpatients with personality disorders
Authors: Vinnars Bo , Barber Jacques P. , Norén Kristina , Thormählen Barbro , Gallop Robert , Lindgren Annika , Weinryb Robert M. 
Published: May 2007

AbstractIntroduction: This study examined whether measures of Personality Disorder (PD) from the Diagnostic and Statistical Manual of Mental Disorder IV, psychodynamic character, psychological mindedness, interpersonal patterns and personality traits predicted treatment outcome for PD patients. Method: Consecutive PD patients were randomly assigned to manualized time‐limited supportive‐expressive psychotherapy (SEP; n = 76) or non‐manualized open‐ended community delivered psychodynamic treatment (CDPT; n = 80). Significant predictors were tested together in order to examine whether they moderated or predicted the reduction of psychiatric symptoms (Symptom Check List‐90). Results: In the entire sample, patients with more severe levels of PD disorderness (number of positive PD criteria) had slower rates of improvement, but patients with more severe levels of vindictiveness (assessed by the Inventory of Interpersonal Problems [IIP]) had higher rates of improvement. High levels of IIP dominance were significantly related to higher rate of improvement in the CDPT treatment compared with SEP. Conclusion: Due to the fact that more severe PD patients had slower rates of improvement, longer treatment may be needed for this population. Specific interpersonal problems may impact whether patients should receive manualized or non‐manualized treatment. Copyright © 2007 John Wiley & Sons, Ltd.
Frequency of fainting, vomiting and incontinence in panic disorder: A descriptive study
Authors: Green Sheryl M. , Antony Martin M. , McCabe Randi E. , Watling Mark A. 
Published: May 2007

AbstractLittle is known about how often individuals with panic disorder (PD) actually experience the physical catastrophes that they fear (e.g., fainting, vomiting, incontinence). This study investigated the frequency of such events in PD and the circumstances under which they occur. A systematic chart review of 574 consecutive patients diagnosed with PD was completed. Nineteen out of 35 patients who had previously reported a history of fainting, vomiting or incontinence (i.e., loss of bowel or bladder control) during a panic attack were interviewed by telephone. Of this sample, 11 confirmed a history of fainting, four confirmed a history of vomiting and four confirmed a history of incontinence during at least one previous panic attack. Four of these individuals reported more than one type of event and several others reported that they had only come close to experiencing these feared events. Participants also reported on the timing of these events (relative to their panic attacks), the circumstances under which the events occurred, as well as possible causes and outcomes of the events. Although rare, catastrophic events such as fainting, vomiting and incontinence appear to occur in the context of panic attacks for some individuals. The implications for cognitive behavioural treatment of PD are discussed. Copyright © 2007 John Wiley & Sons, Ltd.