bluuebunny/crossref_metadata_2025_split huggingface dataset:
No Difference in Bone Tunnel Enlargement and Clinical Outcome between Cortical Suspension and Hybrid Femoral Fixation in Hamstring Anterior Cruciate Ligament Reconstruction
Authors: Lin Yucheng , Zhang Lu , Shen Sinuo , Chen Yuzhi , Xu Li , Ji Mingliang , Guo Yudong , Wei Jinan , Li Yonggang , Wu Xiaotao , Lu Jun 
Published: March 2024

ObjectiveThe best method for femoral fixation in anterior cruciate ligament reconstruction (ACLR) remains controversial. The study assesses the bone tunnel enlargement and clinical outcome in hamstring ACLR using cortical suspension or hybrid (cortical suspension and compression) femoral fixation.MethodsFrom January 2010 to December 2021, 102 patients who underwent quadruple hamstring ACLR using cortical suspension (39 patients) or hybrid (63 patients) fixation on the femoral side were retrospectively analyzed. Clinical evaluation was conducted using the international knee documentation committee score, the Lysholm score, the Tegner activity level scale, the knee injury and osteoarthritis outcome score (quality of life score), the Lachman test, and the side‐to‐side difference by the KT‐1000 arthrometer. The complications after the surgery were also evaluated. These data were compared at baseline and last follow‐up. The diameters of the femoral tunnel were calculated at three sites: the width of the entrance of the femoral tunnel, 1 cm proximal to the entrance of the femoral tunnel and the largest diameter of the femoral tunnel on magnetic resonance imaging (MRI) coronal images. Bone tunnel widening data were contrasted between MRI images conducted at least 2 years and within 2 weeks after surgery. The morphology of bone tunnel enlargement was also observed and recorded. The categorical parameters were analyzed using the χ2‐test and Fisher's exact test. The continuous variables conforming to a normal distribution were analyzed using Student's t‐test, and the Mann–Whitney U‐test was undertaken between the two groups without normal distribution.ResultsBoth cortical suspension and hybrid femoral fixation in quadruple hamstring ACLR achieved significantly improved patient‐reported outcome scores and knee stability compared to preoperative data. However, no significant differences were found between these two methods in clinical evaluations, postoperative complications, and patient‐reported outcome scores. Although the mean diameter of the enlarged bone tunnel was lowered by an additional bioabsorbable interference screw fixation near the joint line, a statistically insignificant difference was found between the hybrid and cortical suspension fixation on the femoral side. There was no statistical difference in the distribution of enlarged bone tunnel morphology between groups.ConclusionsNo significant difference was found in the bone tunnel enlargement and clinical outcome between cortical suspension and hybrid femoral fixation in ACLR using hamstring autograft.
The importance of clinical history in the diagnosis of drug hypersensitivity in children
Authors: Liccioli Giulia , Tomei Leonardo , Pessina Benedetta , Caubet Jean‐Christoph , Barni Simona , Giovannini Mattia , Sarti Lucrezia , Mori Francesca 
Published: March 2024

AbstractBackgroundIn case of suspected hypersensitivity reactions (HRs) to drugs, a challenging area for pediatricians is detecting relevant elements in the parent‐reported history, in order to reach a definite diagnosis. We analyzed the concordance between the description of the HR and the medical reports documented at the time of the event. Furthermore, we studied any correlation between clinical history variables and the prediction of true allergy.MethodsWe retrospectively collected 50 charts of children referred to our Allergy Unit, after a previous access to the Emergency Department. We compared the description of the HR at acute phase to the history told by parents. Type and timing of the HR and culprit drug were classified as “known” or “unknown.” The diagnosis was confirmed or excluded at the end of the investigations. Logistic regression analysis was performed to find any significant association.ResultsThe type of the HR was known in 74%, the timing in 28%, and the culprit drug in 98%. We showed that having had a severe HR had an increased odds of remembering the timing; being older >6 years and having had an immediate HR had an increased odds of remembering the type; time to diagnostic was lower in patients whose parents remembered the type of HR.ConclusionOur paper underlines the importance of an accurate anamnesis at the time of the event. Providing the physicians with a standardized Case Report Form could be a useful tool to simplify the diagnostic work‐up and minimize mistakes due to lack of memory.
Mining exotic germplasm for genetic improvement of protein quantity and quality in soybean (Glycine max)
Authors: Souza Renan , Buckley Blair , Mian M. A. Rouf , Li Zenglu 
Published: March 2024

AbstractSoybean meal is the main protein source for animal feed, but it has low content of the essential amino acids cysteine (Cys) and methionine (Met). In this research, an exotic germplasm (PI 399000) was crossed with ‘Woodruff’ to develop an F5‐derived recombinant inbred line (RIL) population for mapping quantitative trait loci for seed composition. The population was grown in six environments, and protein, oil, Cys, and Met were determined with near‐infrared spectroscopy. RILs were genotyped with the SoySNP6K BeadChip, and 1865 SNPs were used for analysis. QTL analysis identified three loci on chromosomes (Chrs) 6, 15 and 17 in at least five environments for protein; two QTLs on Chrs 14 and 17 in all environments for oil; three QTLs on Chrs 3, 6 and 10 for Cys and Met in at least three environments; and two QTLs for seed size on Chrs 17 and 20 in all environments. Stacking of protein and Cys + Met QTLs can increase both traits simultaneously, and 13 breeding lines were identified with improved seed composition. The markers linked to the QTLs can be used to assist the development of cultivars with improved meal quality.
Corticostriatal causality analysis in children and adolescents with attention‐deficit/hyperactivity disorder
Authors: Zhang Fanyu , Li Yilu , Liu Lin , Liu Yefen , Wang Pan , Biswal Bharat B. 
Published: March 2024

AimThe effective connectivity between the striatum and cerebral cortex has not been fully investigated in attention‐deficit/hyperactivity disorder (ADHD). Our objective was to explore the interaction effects between diagnosis and age on disrupted corticostriatal effective connectivity and to represent the modulation function of altered connectivity pathways in children and adolescents with ADHD.MethodsWe performed Granger causality analysis on 300 participants from a publicly available Attention‐Deficit/Hyperactivity Disorder‐200 dataset. By computing the correlation coefficients between causal connections between striatal subregions and other cortical regions, we estimated the striatal inflow and outflow connection to represent intermodulation mechanisms in corticostriatal pathways.ResultsInteractions between diagnosis and age were detected in the superior occipital gyrus within the visual network, medial prefrontal cortex, posterior cingulate gyrus, and inferior parietal lobule within the default mode network, which is positively correlated with hyperactivity/impulsivity severity in ADHD. Main effect of diagnosis exhibited a general higher cortico‐striatal causal connectivity involving default mode network, frontoparietal network and somatomotor network in ADHD compared with comparisons. Results from high‐order effective connectivity exhibited a disrupted information pathway involving the default mode‐striatum‐somatomotor‐striatum‐frontoparietal networks in ADHD.ConclusionThe interactions detected in the visual‐striatum‐default mode networks pathway appears to be related to the potential distraction caused by long‐term abnormal information input from the retina in ADHD. Higher causal connectivity and weakened intermodulation may indicate the pathophysiological process that distractions lead to the impairment of motion planning function and the inhibition/control of this unplanned motion signals in ADHD.
“I'm so stressed!”: The relational consequences of stress bragging
Authors: Rodell Jessica B. , Shanklin Braydon C. , Frank Emma L. 
Published: March 2024

AbstractFeeling stressed is an unfortunately common experience among employees—and one with significant consequences for personal and professional well‐being. Yet, in addition to trying to manage high stress levels, some employees are actively bragging about it to others at work. Given the general negativity of stress, however, the idea of bragging about stress and its relational implications are unclear. To investigate this phenomenon, we introduce the concept of stress bragging and draw on person‐perception theorizing to examine its potential workplace consequences for both braggarts and their coworkers. In a combination of a lab experiment (Study 1) and a multi‐source field study (Study 2), we show that stress bragging has resoundingly negative implications for braggarts as they are evaluated as less competent and less warm by coworkers, reducing their receipt of citizenship behaviors. Additionally, in Study 2, we find that coworkers of stress braggarts also suffer by experiencing higher levels of burnout due to enhanced stress crossover effects. This research on stress bragging integrates and extends the literatures on stress and self‐promotion, while also providing insight into the relational ramifications of this unconventional behavior.
How couples think about money: Types of money motives and relationship satisfaction
Authors: Peetz Johanna , Joseph Morgan 
Published: March 2024

AbstractTwo studies examined how financial values held by romantic partners were linked with relationship satisfaction. Across a sample of married individuals (N = 628), and a dyadic sample (N = 236), results suggest that holding or perceiving a romantic partner to hold integrated money motives—wanting to earn money to feel pride, establish one's worth, facilitate freedom, and enrich leisure activities—was linked with better relationship satisfaction. Holding or perceiving a romantic partner to hold nonintegrated money motives—wanting to earn money to enable impulse spending, to feel better than others, and to overcome self‐doubt—was linked with worse relationship satisfaction. In both samples, perceived similarity in money motives between the self and the partner was also linked to higher relationship satisfaction. Study 2 further showed that actual similarity between partners in nonintegrated money motives was also linked to better relationship satisfaction, suggesting that even nonintegrated money motives might benefit relationships, as long as both partners share these motives. Overall, these studies suggest that while holding similar financial values as your partner is linked with better relationships, some financial values are more conducive to relationship satisfaction than others.
Indoor point cloud semantic segmentation based on direction perception and hole sampling
Authors: Chen Xijiang , Li Peng , Zhao Bufan , Lu Tieding , Gong Xunqiang , Deng Hui 
Published: March 2024

AbstractMost existing point cloud segmentation methods ignore directional information when extracting neighbourhood features. Those methods are ineffective in extracting point cloud neighbourhood features because the point cloud data is not uniformly distributed and is restricted by the size of the convolution kernel. Therefore, we take into account both multiple directions and hole sampling (MDHS). First, we execute spherically sparse sampling with directional encoding in the surrounding domain for every point inside the data to increase the local perceptual field. The data input is the basic geometric features. We use the graph convolutional neural network to conduct the maximisation of point cloud characteristics in a local neighbourhood. Then the more representative local point features are automatically weighted and fused by an attention pooling layer. Finally, spatial attention is added to increase the connection between remote points, and then the segmentation accuracy is improved. Experimental results show that the OA and mIoU are 1.3% and 4.0% higher than the method PointWeb and 0.6% and 0.7% higher than the baseline method RandLA‐Net. For the indoor point cloud semantic segmentation, the segmentation effect of the proposed network is superior to other methods.
Changing the narrative: Loneliness as a social justice issue
Authors: Barreto Manuela , Doyle David Matthew , Qualter Pamela 
Published: March 2024

AbstractLoneliness is most often understood as resulting from individual deficits that shape poor social engagement and unsatisfying interactions. As a consequence, interventions to address loneliness most often focus on fixing the lonely individual, for example, by modifying their social appraisals and skills, or encouraging them to get out more. In this paper, we characterize and contribute to changing this dominant narrative by arguing that it is both unhelpful and incomplete. We explain that this dominant narrative (1) increases loneliness and makes people feel worse about this experience, (2) does not account for important predictors of loneliness, (3) guides us to interventions that do not produce sufficiently effective or sustainable change, and (4) hinders broader understandings of the societal impact of loneliness. In this way, we argue that the dominant narrative around loneliness contributes to further setting those who feel lonely apart from the rest of society. We propose that attention to individual factors needs to be complemented by the acknowledgement that loneliness is heavily determined by social and structural conditions that render it unequally distributed in society, a situation that qualifies loneliness as a social justice issue.
Is the “avoidance” group truly defensive? The interplay between perceived risk, efficacy, and behaviors
Authors: Li Ruobing 
Published: March 2024

AbstractThis study examines the inconsistent theories surrounding the roles of perceived threat and efficacy in risk communication theories, focusing on behavioral changes during a public health crisis. Utilizing a two‐wave panel survey, the research found a nuanced interaction between efficacy beliefs and risk perceptions in dictating individuals’ engagement in protective or defensive behaviors. Notably, those with high risk perceptions but lower efficacy beliefs were more likely to engage in future protective behaviors, contradicting previous assumptions about the avoidance group's propensity for defensive reactions. These findings initiate a complex discussion on the dynamics of risk and efficacy perceptions influencing behavior.
Double whammy? Trade and automation in engineering services
Authors: Klügl Franziska , Nordås Hildegunn Kyvik 
Published: March 2024

AbstractThis paper studies the role of trade for the joint uptake of AI‐enabled automation in manufacturing and engineering. It develops an agent‐based model (ABM) where the agents are heterogeneous manufacturers and engineering firms. The ABM features two technology‐related business models: engineering as a face‐to‐face consultancy service and engineering as automated software. The software adoption rate follows an S‐shaped curve for manufacturers and a boom and bust cycle for engineers. In the early phase, shortage of engineers constrains AI uptake, while engineers become abundant when AI is fully adopted. Trade affects the cut‐off productivity level at which manufacturers switch technology, the shape of the adoption rate curve, and the incentives for engineers to develop software. Bulky transactions and different productivity distributions across countries are drivers of trade in their own right.
Systematic analysis of mucosal‐associated invariant T cells in haematological malignancies
Authors: Bacova Barbora , Cierny Jakub , Nemcekova Lucia , Smetanova/Brozova Jitka , Novak Jan 
Published: March 2024

AbstractMucosal‐associated invariant T‐cells (MAIT) are unconventional T‐cells with cytotoxic and pro‐inflammatory properties. Previous research has reported contradictory findings on their role in cancerogenesis with data being even scarcer in haematological malignancies. Here, we report the results of a systematic analysis of MAIT cells in treatment‐naïve patients with a broad range of haematological malignancies. We analysed peripheral blood of 204 patients and 50 healthy subjects. The pool of haematological patients had a statistically significant lower both the absolute value (median values, 0.01 × 109/L vs. 0.05 × 109/L) of MAIT cells and their percentage (median values 0.94% vs. 2.56%) among T‐cells compared to the control group. Separate analysis showed that the decrease in the absolute number of MAIT cells is significant in patients with acute myeloid leukaemia, myeloproliferative neoplasms, plasma cell myeloma, B‐cell non‐Hodgkin lymphomas, otherwise not specified, diffuse large B‐cell lymphoma, follicular lymphoma, mantle cell lymphoma, marginal zone lymphoma compared to the control population. Furthermore, in haematological malignancies, MAIT cells overexpress PD‐1 (average values, 51.7% vs. 6.7%), HLA‐DR (average values, 40.2% vs. 7%), CD38 (average values, 25.9% vs. 4.9%) and CD69 (average values, 40.2% vs. 9.2%). Similar results were obtained when comparing patients with individual malignancies to the control population. Our data show that the depletion of circulating MAIT cells is a common observation in a broad spectrum of haematological malignancies. In addition to their reduced numbers, MAIT cells acquire an activated/exhausted phenotype.
Folding Miura-Ori of Uniform Thickness With One Degree-of-Freedom
Authors: Yang Jingyi , You Zhong 
Published: March 2024

Abstract
The Miura-ori is an origami pattern with bi-directional folding capable of transforming a large thin sheet into a compact volume with a single degree-of-freedom (DoF). A common Miura-ori pattern consists of identical rigid parallelogram facets that can rotate about the creases without twisting or stretching. However, large gaps along the hinges or uneven surfaces in deployed states are inevitable when thick panels are used. In this paper, the authors add uniform thickness to a Miura-ori tessellation and connect the thick panels by revolute joints on either the top or the bottom facets of the panels for valley creases or mountain creases, respectively. To enable its folding, regular slits are made on some facets not only to remove the excess kinematic constraints but also to accommodate the panel thickness during the folding process. Having made the cuts, we demonstrate that the resultant assembly can fold into a compact package with one DoF. We further notice that although the slits open up during the folding process, they close in the deployed state of the assembly, giving flat and continuous surfaces on both the top and bottom sides. The same method can also be applied to fold the derivatives of the Miura-ori, such as double-corrugated patterns.
Supporting a National Team During the Overwatch World Cup: Three Confessional Tales
Authors: Brain Jonathan , Wright Oliver , Quartiroli Alessandro , Wagstaff Christopher R.D. 
Published: March 2024

There is currently a lack of understanding of how sport psychology practitioners navigate the nuances of working within the esports domain in the applied sport psychology literature. Therefore, the current case study provides three confessional tales, which aim to outline the unique experiences of two sport and exercise psychologists in training, working with a national Overwatch esports team during the World Cup preparation period. We first provide contextual elements of the World Cup format, the roster, the team’s needs, and the program of work. In the form of confessional tales, we share a series of critical reflections concerning the challenges and nuances we experienced, specifically: (a) the limited time afforded to deliver our services, (b) the misalignment in values experienced with the players and staff in the organization, and (c) working without visual cues with the members of the team. We conclude this case study by providing a series of recommendations for practitioners seeking to work with elite esports teams preparing for high-level competitions while delivering ethical and effective services.
BPR3P0128, a non-nucleoside RNA-dependent RNA polymerase inhibitor, inhibits SARS-CoV-2 variants of concern and exerts synergistic antiviral activity in combination with remdesivir
Authors: Tang Wen-Fang , Chang Yu-Hsiu , Lin Cheng-Chin , Jheng Jia-Rong , Hsieh Chung-Fan , Chin Yuan-Fan , Chang Tein-Yao , Lee Jin-Ching , Liang Po-Huang , Lin Chia-Yi , Lin Guan-Hua , Cai Jie-Yun , Chen Yu-Li , Chen Yuan-Siao , Tsai Shan-Ko , Liu Ping-Cheng , Yang Chuen-Mi , Shadbahr Tolou , Tang Jing , Hsu Yu-Lin , Huang Chih-Heng , Wang Ling-Yu , Chen Cheng Cheung , Kau Jyh-Hwa , Hung Yi-Jen , Lee Hsin-Yi , Wang Wen-Chieh , Tsai Hui-Ping , Horng Jim-Tong 
Published: March 2024

ABSTRACT

Viral RNA-dependent RNA polymerase (RdRp), a highly conserved molecule in RNA viruses, has recently emerged as a promising drug target for broad-acting inhibitors. Through a Vero E6-based anti-cytopathic effect assay, we found that BPR3P0128, which incorporates a quinoline core similar to hydroxychloroquine, outperformed the adenosine analog remdesivir in inhibiting RdRp activity (EC
50
= 0.66 µM and 3 µM, respectively). BPR3P0128 demonstrated broad-spectrum activity against various severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern. When introduced after viral adsorption, BPR3P0128 significantly decreased SARS-CoV-2 replication; however, it did not affect the early entry stage, as evidenced by a time-of-drug-addition assay. This suggests that BPR3P0128’s primary action takes place during viral replication. We also found that BPR3P0128 effectively reduced the expression of proinflammatory cytokines in human lung epithelial Calu-3 cells infected with SARS-CoV-2. Molecular docking analysis showed that BPR3P0128 targets the RdRp channel, inhibiting substrate entry, which implies it operates differently—but complementary—with remdesivir. Utilizing an optimized cell-based minigenome RdRp reporter assay, we confirmed that BPR3P0128 exhibited potent inhibitory activity. However, an enzyme-based RdRp assay employing purified recombinant nsp12/nsp7/nsp8 failed to corroborate this inhibitory activity. This suggests that BPR3P0128 may inhibit activity by targeting host-related RdRp-associated factors. Moreover, we discovered that a combination of BPR3P0128 and remdesivir had a synergistic effect—a result likely due to both drugs interacting with separate domains of the RdRp. This novel synergy between the two drugs reinforces the potential clinical value of the BPR3P0128-remdesivir combination in combating various SARS-CoV-2 variants of concern.