bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE IMPACT OF NEUROMARKETING ON SOCIAL MEDIA DIGITAL CONTENT OPTIMIZATION
Authors: Дарибаева А.К. , Daribayeva A. 
Published: February 2024

В статье рассматривается инновационное объединение методов нейромаркетинга со стратегиями цифрового контента для повышения эффективности взаимодействия с потребителями на платформах социальных сетей. В работе показано, как нейромаркетинг, объединяющий принципы нейронауки и маркетинга, позволяет понять нейронные реакции потребителей на маркетинговые инициативы. Автор выявляет, что центральное место и ключевая роль нейромаркетинга в цифровом ландшафте заключается в формировании потребительского восприятия и решений с помощью контента социальных сетей. Рассмотрена роль социальных сетей в формировании потребительского восприятия и поведения, проанализированы влияние нейромаркетинга на понимание цифрового контента потребителями, определены методы нейромаркетинга для улучшения качества и воздействия цифрового контента, предложены практические примеры применения нейромаркетинга в цифровом контенте. В статье подчеркивается необходимость нейромаркетинга в создании цифрового контента, который глубоко резонирует с потребителями, затрагивая инстинктивные и эмоциональные слои вовлечения. Статья доказывает необходимость интеграции этих подходов в качестве важнейшего элемента современной маркетинговой тактики, направленной на объединение понимания когнитивных процессов потребителей с совершенствованием цифрового маркетингового контента. Исследование автора представляет убедительные аргументы в пользу такой интеграции для разработки эффективных современных маркетинговых стратегий.
The article discusses an innovative combination of neuromarketing methods with digital content strategies to improve the effectiveness of interaction with consumers on social media platforms. The article shows how neuromarketing, combining the principles of neuroscience and marketing, allows us to understand the neural reactions of consumers to marketing initiatives. The author shows that the central place and key role of neuromarketing in the digital landscape is to form consumer perceptions and decisions using social media content. The role of social networks in the formation of consumer perception and behavior is considered, the influence of neuromarketing on the understanding of digital content by consumers is analyzed, neuromarketing methods for improving the quality and effectiveness of digital content are identified, practical examples of the use of neuromarketing in digital content are proposed. The article highlights the need for neuromarketing in creating digital content that resonates deeply with consumers, affecting the instinctive and emotional levels of engagement. The article proves the need to integrate these approaches as an essential element of modern marketing tactics aimed at combining understanding of consumers' cognitive processes with improving digital marketing content. The study presents convincing arguments in favor of such integration as the cornerstone of effective modern marketing strategies.
PANKREAS DUKTAL ADENOKARSİNOMUNDA İLAÇ DİRENCİNİN MOLEKÜLER TEMELLERİ, IN VITRO, EX VIVO VE IN VIVO PREKLİNİK MODELLEMELER
Authors: KAYA Yağmur , BİLDİK Ezel , KOÇDOR Hilal 
Published: February 2024

Pankreas duktal adenokarsinomu (PDAK); tanı aldığında ileri evrelere ulaşmış olan, agresif seyirli bir malignitedir. 5 yıllık genel sağkalım oranı yalnızca %7’dir. Tümör mikroçevresinin spesifik özellikleri ve erken dönemde metastaz yapması da dahil birçok özelliği nedeniyle mortalite oranını düşürebilecek etkin bir tedavi yöntemi bulunmamaktadır. Diğer solid tümörler ile karşılaştırıldığında, uygulanan terapötik rejimler PDAK’nin tedavi direnci nedeniyle çok daha etkisiz kalmaktadır. PDAK’nin kompleks tümör mikroçevresinin tümör progresyonuna sağladığı katkı ve bunun preklinik modellere yansıtılması, klinikte kullanılması amaçlanan yeni terapötik ajanların geliştirilebilmesi için önemlidir.
Bu derlemede, PDAK’nin moleküler özellikleri, tümör mikroçevresi ve tedavi direncinin moleküler temelleri ele alınmış; uygulanması hedeflenen tedavilerin klinikteki uygulamadan önceki süreçleri olan in vitro, ex vivo ve in vivo preklinik modellemelerden bahsedilmiştir.
Esansiyel Trombositozlu Hastalarda Kalsiyum, Fosfor ve Arsenik Elementlerinin Analizi
Authors: KARIŞ Denizhan , ÖZKAN TEKİN Tuba , ATEŞ Fatma , ÇETİN Güven , ERCAN Alev Meltem 
Published: February 2024

Amaç: Esansiyel trombositoz, trombositlerde ciddi artış ve fonksiyon bozukluğuna sebep olan kök hücre kökenli nadir bir hastalıktır. Trombositlerin fonksiyonlarındaki bozulma ve artan aktiviteleri sonucunda, yapılarında bulunan granüllerden özgün moleküller salgılanmaktadır. Esansiyel trombositozda görülen hiperkalsemi, sayıca artan ve aktiviteleri artan trombositlerden kalsiyum salgılanmasına bağlıdır. Ayrıca, esansiyel trombositoz hastalarında artan serum fosfor düzeyi pıhtılaşma sırasında hücre içinden hücre dışına salınmasıyla ilişkili olabilir. Toksik bir element olan arsenik, trombositlerin yapısal değişikliklerine bağlı olarak ateroskleroza yol açan lipit peroksidasyonunu ve oksidatif stresi tetiklemektedir. Bu çalışmanın amacı serum kalsiyum, fosfor ve arsenik düzeylerindeki değişimlerin esansiyel trombositozun patogenez ve prognozuna etkilerini araştırmaktır.
Yöntem: Çalışma grupları esansiyel trombositoz tanısı alan hastalar (Grup-1,n:40), demir eksikliği anemisine bağlı reaktif trombositoz hastaları (Grup-2,n:40) ve sağlıklı kontroller (Grup-3 n:40) olarak oluşturuldu. Serum kalsiyum, fosfor ve arsenik düzeyleri indüktif eşleşmiş plazma atomik emisyon spektrofotometresi kullanılarak analiz edildi.
Bulgular: Grup-1’de serum kalsiyum düzeyleri Grup-2 ve Grup-3’e göre anlamlı derecede yüksek olarak belirlendi (sırasıyla; p=0,001, p=0,006). Grup-1 ve Grup-2’nin serum arsenik düzeyleri Grup-3’ten yüksekti (p=0,000), ayrıca Grup-2’nin serum arsenik düzeyleri Grup-3’e göre daha yüksekti (p=0,000).
Sonuç: Bu çalışma, değişen yapı ve fonksiyonlarıyla trombositlerin aktivitelerindeki artışı ortaya çıkardı. Esansiyel trombositoz grubunda serum kalsiyum düzeylerinin yüksek olması, aktif trombositlerden hücre dışına salgılanan kalsiyuma bağlı olabileceği düşüncesindeyiz.
Benzer şekilde, trombositoz gruplarında serum arsenik düzeyinindeki artış ise, trombosit membranındaki lipit peroksidasyona bağlı olarak oksidatif strese maruz kaldığının göstergesi olabilir.
Kardiyak Cerrahi Sonrası Postoperatif Bilişsel Fonksiyon Bozukluğu; Görülme sıklığı ve Risk Faktörleri
Authors: ÇARDAKÖZÜ Tülay , TALAS Zeki , YUCAL Nur Nazire , GUR Sibel , YEŞİLDAL Huri , YAVUZ Şadan 
Published: February 2024

Öz
Kardiyak Cerrahi Sonrası Postoperatif Bilişsel Fonksiyon Bozukluğu; Görülme sıklığı ve Risk Faktörleri
Amaç:
Çalışmamızın amacı merkezimizde kalp cerrahisi sonrası kognitif bozulma görülme sıklığını ve risk faktörlerini araştırmaktır.
Yöntem:
01-01-2021 ve 31-12-2021 tarihleri arasında kalp cerrahisi planlanan 18-70 yaş arası ASA II-III hastaları çalışmaya dahil edildi. Ameliyat sonrası bilişsel bozukluk (POBB) tanısı mini mental durum testi (MMDT) ile konuldu. MMDT ameliyat öncesi ve ameliyat sonrası 7. gün ve 8. haftada yapıldı.
MMDT puanı
Implementasi Metode Perhitungan Margin Pada Akad Pembiayaan Murabahah BMT UGT Sidogiri
Authors: Millah Hayatul , Hayati Nur 
Published: February 2024

ABSTRACT
This study aims to determine the implementation of the margin calculation method on murabahah financing contracts at BMT UGT Sidogiri Capem Semampir Kraksaan Probolinggo. This type of research is a qualitative research. Qualitative method is a research method that uses the philosophy of positivism as a basis, this method is used to conduct research in conditions of natural objects. This study shows the results that the percentage margin for murabahah financing is determined by the size of the financing ceiling proposed by each customer, at BMT UGT Sidogiri Capem Semampir Kraksaan Probolinggo, the maximum ceiling in accordance with the policy of the Islamic Bank central team is only 50,000,000 . BMT UGT Sidogiri Capem Semampir Kraksaan Probolinggo in calculating the profit margin for murabahah financing using the principal calculation method, which is a simple formula used by BMT to determine the total installments, principal financing and profit margins.
Analisis Motivasi Kerja Dan Kinerja Karyawan Di Klinik Pusat Bekam Dan Ruqyah Pedurenan
Authors: Ishak Muhammad Nur 
Published: February 2024

ABSTRACT
Work motivation and employee performance have an important role in the running of the company, in this case the Cupping Center Clinic and Ruqyah, as well as to meet the service standards that have been determined and to be able to survive in the competition amid the rampant business of similar types lately. In this study, the authors wanted to analyze the work motivation and performance of employees at the Center of Cupping and Ruqyah Pedurenan clinics using qualitative methods by interviewing several employees and heads of clinic branches of the Center for Cupping and Ruqiyah Pedurenan. And with this research, the authors conclude that employees of the Central Cupping Center Clinic and Ruqyah Pedurenan employees are less satisfied with the salary received, and the work motivation and performance of employees decrease, even though employees still have motivation to survive because of several factors including life necessities, but more It is important to want to create a better work environment, because with work motivation and good performance hope to be able to improve work careers and also change in income.
Qiyas Dalam Tinjauan Hukum Islam
Authors: Hakimi Fifi , Billah Wahidin Musta’in 
Published: February 2024

ABSTRAK
Teori qiyas telah mengalami perkembangan yang sangat pesat dalam bentuk ini ke arah yang secara abduktif yang sebelum nya masih dalam lingkup secara deduktif, di dalam pemikiran yang diatur dalam hukum hukum islam sendiri memiliki hal luar dalam konsep qiyas di masa islam yang bersifat kontemporer, sejak awal qiyas ini menjadi hal teoritis selalu dilaksanakan para ahli hukum islam, yang di mana secara konsep tidak pernah mengalami perubahan dalam menangani masalah yang sering muncul dalam lingkup kontemporer. Bukan berarti memiliki batasan dalam mencari secara luas illat yang diteorikan hukum qiyas, dan tidak juga terbatas dalam konsep material secara garis konkret atau secara konseptual . namun secara penjelasan yang diberikan dalam permasalahan apapun dapat diartikan secara meluas dan rinci untuk mengatasi nya. Berbagai pertanyaan dan pernyataan akan diulas dan dipecahkan sebagaimana hukum islam mengatur dalam aqidah
PENERAPAN PROSEDUR TERAPI RELAKSASI BENSON DAN MUROTTAL AL-QUR’AN SURAH AR-RAHMAN AYAT 1-78 TERHADAP TEKANAN DARAH PADA PASIEN HIPERTENSI PRIMER DI RSUD UNGARAN
Authors: Ns. Dwi Mulianda  , Ela Lutfiatul Umah  
Published: February 2024

An increase in blood pressure that is not controlled will provide some further symptoms to organs such as the brain in the form of strokes, and heart in the form of coronary heart disease and hypertrophy. Benson relaxation and murottal Al-Qur'an surah Ar-Rahman ayat 1-78 is a nonpharmacological therapy that can reduce blood pressure in patients with primary hypertension so as to prevent further symptoms of hypertension. This case study aims is to discribe the application Benson relaxation and murottal Al-Qur'an surah Ar-Rahman ayat 1-78 to the reduction in blood pressure in patients with primary hypertension at RSUD Ungaran. The method of this study is descriptive. The subjects of this case study are two Moslem patients with hypertension who have no hearing problems. The data are collected through observation and measurement by using medical tools such as sphygmomanometer and stethoscope before and after the therapy. The result of this study shows that the blood pressure in subject I decreased blood pressure from 175/90 mmHg to 140/30 mmHg, while in subject II decreased blood pressure from 160/100 mmHg to 125/80 mmHg. The results of this case study reveal that the application Benson relaxation therapy and murottal Al-Qur’an surah Ar-Rahman ayat 1-78 shows the results of a decrease in blood pressure that is quite effective in patients with primary hypertension in RSUD Ungaran. Hopefully, Ungaran hospital can make Benson relaxation and Murottal Al-Qur'Aan relaxation surah Ar-Rahman ayat 1-78 as a basis for the development of nursing and companion of pharmacological therapy.
Klasifikasi Penyakit Daun Tomat Menggunakan Algoritma K-NN Berdasarkan Ekstraksi Fitur GLCM dan LBP
Authors: Fuad Mahrus Fathoni  
Published: February 2024

Tomatoes are widely cultivated in Indonesia and are one of the crops with high economic value. According to the Central Bureau of Statistics, the Indonesian nation has the capacity to produce up to 1. 17 million tons of tomatoes in 2020. Tomatoes contain ingredients that the body needs. Additionally, grapes can also be consumed in different forms. However, tomato production in Indonesia decreased from 2013 to 2015 due to the spread of pests. Therefore, we conducted a study to classify tomato leaf diseases using the K-nearest neighbor method based on the grayscale coexistence matrix and the extraction of local binary pattern features. The data used was 9157 data obtained from the Plant Village database and classified into 6 classes (healthy, spot fungus, late blight, leaf mold, mosaic virus, spider mite, and target spot). The testing process was performed using the K-fold cross-validation technique, followed by performance calculations using the confusion matrix method. The highest accuracy was obtained at 86.8% when classifying using K9 and K10 with a precision value 40.6% and recall 49.2% when classifying using a value of K = 9, and precision 49.7% and recall of 49.3% when classifying using a value of K = 10.
THE RELATIONSHIP OF CLASS II STUDENTS' READING INTEREST WITH SYLLABLE PUZZLE MAGIZING MEDIA AT SDN 27 WOJA DOMPU
Authors: Adiprasetio Prabowo  , Ardiansyah  
Published: February 2024

Penelitian ini bertujuan mendeskripsikan upaya meningkatkan minat membaca siswa kelas II dengan media magiz puzzle dan hasil penggunaan media magiz puzzle suku kata dalam meningkatkan keterampilan membaca. Jenis penelitian ini ialah penelitian tindakan kelas dengan menggunakan metode observasi, dokumentasi dan wawancara. Sampel penelitian diambil kelas II A berjumlah 25 orang. Berdasarkan hasil analisis data penelitian ditemukan bahwa penggunaan media puzzle suku kata dapat meningkatkan minat baca pada peserta didik Siswa kelas IV di SDN 27 Woja Dompu. Hasil dari pembelajaran siklus I mencapai 62% dan hasil dari siklus II mencapai 79%. Hasil penelitian menunjukan terjadi peningkatan secara signifikan disetiap tindakan yang telah dilakukan. Peningkatan minat membaca peserta didik telah sesuai dengan kriteria keberhasilan yang diinginkan dalam penelitian.
Analisis Sistem Informasi Akuntansi Penerimaan Kas Dari Penjualan Tiket Bus Pada PT Luragung Jaya Lestari
Authors: Adam Huda Nugraha  
Published: February 2024

Penelitian ini bertujuan Untuk menganalisis sistem informasi akuntansi dan prosedur penerimaan kas dari penjualan tiket bus PO Luragung Jaya dan Untuk mengevaluasi sistem informasi akuntansi dan prosedur yang diterapkan pada perusahaan PO. Luragung Jaya sudah sesuai atau belum berdasarkan aspek bisnis. Metode penelitian adalah kualitatif, sedangkan teknik analisis data yang digunakan adalah analisis deskriptif pendekatan kualitatif. Dalam teknik pengumpulan data penelitian ini mencakup survei pendahuluan, studi lapangan dengan wawancara dan dokumentasi. Hasil yang diperoleh dari penelitian ini adalah sistem informasi akuntansi dan prosedur dalam penerimaan kas sudah sesuai aspek bisnis, namun belum cukup baik. Ada beberapa pendokumentasian yang belum sesuai dan kegiatan yang dilaksanakan tanpa adanya aturan khusus yang berkesinambungan. Sistem penerimaan kas menggunakan sistem komputerisasi namun belum semua, ada beberapa yang masih manual menyebabkan ketidakseragaman dalam pencatatan yang bisa berakibat menimbulkan ketidakefektifan dalam pengecekan di masa yang akan datang.
SOSIALISASI PENGGUNAAN DIGITAL MARKETING UNTUK PENGEMBANGAN UMKM DAN MENINGKATKAN DAYA SAING
Authors: Hidayah Rahmad , Faiq Faiq , Kristriantoro Febby 
Published: February 2024

Penyebab daya saing Usaha Mikro Kecil dan Menengah (UMKM) masih tergolong rendah salah satunya dikarenakan terbatasnya kemampuan para pelaku UMKM dalam melakukan pemasaran. Kegiatan sosialisai pada pelaku usaha ini meliputi observasi dan pemantauan langsung serta melakukan pendekatan langsung kepada pelaku usaha untuk mempraktikkan penerapan pemasaran produk melalui digital marketing. Tujuan utama penggunaan digital marketing sebagai alat pemasaran khususnya bagi UMKM. Meskipun pemasaran digital kini menjadi pendekatan baru, pemasaran tradisional masih relevan dan keduanya memiliki manfaat.Metode yang di gunakan dalam pelaksanaan yaitu ABCD (Aset Based Community Development) dengan jumlah peserta 8 orang. Peserta memahami pentingnya pemasaran digital berbasis internet dan penggunaan media sosial dan platform e-commerce untuk mengembangkan bisnis mereka. Informasi terkait target pasar, tujuan pemasaran digital, dan jenis media pemasaran digital telah dikomunikasikan dengan cara yang mudah dipahami kepada para pemangku kepentingan UMKM. Hasil dari kegiatan ini peserta mampu membuka peluang dan wawasan untuk memanfaatkan media sosial dan platform e-commerce sebagai alat untuk menarik perhatian dan berinteraksi secara lebih efektif dengan konsumen.
The Implementation of Fire Disaster Mitigation at Harris Vertu Hotel Jakarta
Authors: Rina Kurniawati  , Aji Mahaditia  , M.Rizka Galang Y  
Published: February 2024

Purpose: This research aims to find out and explain how the Harris Vertu Jakarta hotel is implemented in dealing with disasters that are likely to occur, especially fire disasters, disasters are something that cannot be predicted, and knowing how to deal with disasters is one of the skills that is needed in the hotel industry. because it is an obligation to make hotels safe from the threat of disasters, there are three types of disasters, natural disasters, non-natural disasters, and social disasters. In this research, researchers will conduct research related to non-natural disasters at the Harris Vertu hotel, namely fire disasters.
Reseach metods: This study used qualitative-descriptive research techniques that used observation, interviews, and documentation to collect data. The samples of this study is HR Director, Chief Security, and Chief Engineer. Then the results of the data collected will be described descriptively.
Result and discussion: The haris Vertu Hotel Jakarta has prepared the staffs to face disasters from the first day the staff worked at the Harris Vertu hotel where on the first day of work they were immediately given a full day of training, usually the training is given by HRD about hotel brands, executive chefs about hygiene, Chief Security about how to respond to disasters. In addition to the training provided on the first working day of the Harris Vertu hotel, it is also routine to conduct training every three months on how to deal with disasters if at any time they occur at the Harris Vertu hotel, things to do when disasters occur and how to use the tools used to deal with disasters.Harris Vertu Hotel also routinely conducts simulations every four months for all its staff, in the simulation each staff is given the opportunity to use all the equipment used to deal with disasters, besides that Hrris Vertu hotel also collaborates with outside parties to carry out this simulation, such as by ambulance, and fire department.
Implication: This study focuses to answer the following questions: 1) How does Harris Vertu Hotel prepare for natural disasters, 2) How does Harris Vertu Hotel prepare its staff to face natural disasters.

Keywords: Hotel, Fire, Non-natural Disaster, Disaster Mitigation
Treatment of patients hospitalized for COVID-19 with remdesivir is associated with lower likelihood of 30-day readmission: a retrospective observational study
Authors: Mozaffari Essy , Chandak Aastha , Gottlieb Robert L , Chima-Melton Chidinma , Kalil Andre C , Sarda Vishnudas , Der-Torossian Celine , Oppelt Thomas , Berry Mark , Amin Alpesh N 
Published: February 2024

Aim:
This observational study investigated the association between remdesivir treatment during hospitalization for COVID-19 and 30-day COVID-19-related and all-cause readmission across different variants time periods.
Patients & methods:
Hospitalization records for adult patients discharged from a COVID-19 hospitalization between 1 May 2020 to 30 April 2022 were extracted from the US PINC AI Healthcare Database. Likelihood of 30-day readmission was compared among remdesivir-treated and nonremdesivir-treated patients using multivariable logistic regression models adjusted for age, corticosteroid treatment, Charlson comorbidity index and intensive care unit stay during the COVID-19 hospitalization. Analyses were stratified by maximum supplemental oxygen requirement and variant time period (pre-Delta, Delta and Omicron).
Results:
Of the 440,601 patients discharged alive after a COVID-19 hospitalization, 248,785 (56.5%) patients received remdesivir. Overall, remdesivir patients had a 30-day COVID-19-related readmission rate of 3.0% and all-cause readmission rate of 6.3% compared with 5.4% and 9.1%, respectively, for patients who did not receive remdesivir during their COVID-19 hospitalization. After adjusting for demographics and clinical characteristics, remdesivir treatment was associated with significantly lower odds of 30-day COVID-19-related readmission (odds ratio 0.60 [95% confidence interval: 0.58–0.62]), and all-cause readmission (0.73 [0.72–0.75]). Significantly lower odds of 30-day readmission in remdesivir-treated patients was observed across all variant time periods.
Conclusion:
Treating patients hospitalized for COVID-19 with remdesivir is associated with a statistically significant reduction in 30-day COVID-19-related and all-cause readmission across variant time periods. These findings indicate that the clinical benefit of remdesivir may extend beyond the COVID-19 hospitalization.
Ubiquitin: Structure and Function
Authors: T. Dongdem Julius , P. Dawson Simon , Layfield Robert 
Published: February 2024

Ubiquitin is a small (8.6 kDa) protein that is found ‘ubiquitously’ in eukaryotic organisms and functions as a regulator of numerous cellular processes. It is a multifaceted post-translational modifier of other proteins involved in almost all eukaryotic biology. Once bound to a substrate, ubiquitin initiates a plethora of distinct signals with unique cellular outcomes known as the ‘ubiquitin code’. More recently, much progress has been made in characterising the roles of distinct ubiquitin modifications though it is anticipated that more is yet to be unravelled as several questions remain elusive. The major aim of this chapter is to comprehensively review in detail using published data, the current understanding of the physico-chemical properties and structure (primary, secondary and tertiary) of ubiquitin, outlining current understanding of ubiquitin signal regulatory functions (Ubiquitin Proteasome System) and ubiquitin combinations, with emphasis on the structural relation to its function. Synthesis of ubiquitin (genes) will be illustrated. Additionally, ubiquitin-mediated processes and various possible covalent modifications of ubiquitin and their known functions will be illustrated. Deubiquitinase-dependent deubiquitylation of the ubiquitin code will also be described. Finally, ubiquitin-binding proteins and their ubiquitin-binding domains, the consequences of post-translational modification of ubiquitin by phosphorylation and future prospects will be discussed.