bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Performance of Immunonephelometric Assay and Chemiluminescent Immunoassay for Detection of IgG Subclasses in Chinese
Authors: Qin Yan , Jia Yuhan , Liang Congcong , Fu Rui , Liang Zhaojun , Wang Yanlin , Feng Min , Gao Chong , Luo Jing 
Published: April 2024

ABSTRACTBackgroundDetection of IgG subclasses (IgGSc) is vital for the diagnosis and management of disease, especially IgG4‐related diseases (IgG4‐RD). This study aimed to evaluate the performances of the chemiluminescent immunoassay (CLIA) for detecting IgGSc and diagnosing IgG4‐RD by IgGSc.MethodsA total of 40 individuals with IgG4‐RD, 40 with primary Sjogren's syndrome (pSS), and 40 healthy controls (HCs) were enrolled. Serum samples were collected for the simultaneous detection of IgG1, IgG2, IgG3, and IgG4 by the Siemens immunonephelometric assay and the CLIA. The correlation analysis was performed, and diagnostic value was analyzed by the receiver operating characteristic (ROC) curve.ResultsPatients with IgG4‐RD had higher IgG4 (p < 0.001) and lower IgG1 (p < 0.001) than those with pSS, and HC. The results by the Siemens immunonephelometric assay and the CLIA showed a strong correlation in detecting IgG1, IgG2, IgG3, and IgG4 (r = 0.937, r = 0.847, r = 0.871, r = 0.990, all p < 0.001, respectively). The sum of IgG1, IgG2, IgG3, and IgG4 using two assays strongly correlated with total IgG by the IMMAGE 800 (r = 0.866, r = 0.811, both p < 0.001, respectively). For discriminating IgG4‐RD from pSS and HC, no significant differences were observed in CLIA IgG4 and Siemens immunonephelometric assay IgG4 (z = 0.138, p = 0.891), which provided the area under the curves (AUCs) of 0.951 (p < 0.001) and 0.950 (p < 0.001), respectively. The AUCs of CLIA IgG1 and Siemens immunonephelometric assay IgG1 in distinguishing pSS from IgG4‐RD and HC were 0.761 (p < 0.001) and 0.765 (p < 0.001), respectively, with no significant differences (z = 0.228, p = 0.820).ConclusionsThe CLIA and the Siemens immunonephelometric assay appeared to have good consistency with comparable diagnostic value in detecting IgGSc, especially IgG4, and IgG1 that can accurately identify IgG4‐RD or pSS in clinical practice.
Ion‐imprinted thiosalicylichydrazide‐based sorbents for selective recognition of mercury(II) ions
Authors: Alenazi Duna AK , Alamrani Nasser A , Almutairi Fahad M , Alotaibi Fatimah A , Foud Moustafa M , Al‐Sayed Hanan MA , Elsayed Nadia H 
Published: April 2024

AbstractBACKGROUNDThe study of removing heavy metals from water through the use of chelating adsorbents is an emerging and critical area of research. However, the challenge lies in the lack of specificity that these adsorbents often exhibit towards individual metals.RESULTSIn addressing this challenge, we have synthesized a novel chelating polymer, thiosalicylichydrazidine‐modified poly(acrylonitrile‐co‐divinylbenzene) copolymer (TSH‐P), demonstrating a high affinity for Hg2+ ions. The crosslinking of the Hg2+/TSH‐P complex with a glyoxal crosslinking agent effectively encapsulates Hg2+ ions, stabilizing the functional chelating groups within the coordination geometry of Hg2+. The ions were subsequently removed with EDTA/HNO3, producing a sorbent imprinted with Hg2+ ions (Hg‐IIP). Analytical techniques were employed for a detailed examination of each synthesis step, confirming the successful chelation of Hg2+. Notably, the synthesized Hg‐IIP showed significant selectivity for Hg2+ over other metal cations, with an optimal adsorption pH of 5 and a maximum capacity of 350 mg g−1. The adsorption process was found to closely follow the Langmuir isotherm model, with kinetics that adhered to the pseudo‐second‐order model.ConclusionThis study introduces a highly selective chelating polymer for the removal of Hg2+ ions from water, highlighting its effectiveness and potential for specificity in heavy metal remediation. The use of analytical techniques to confirm the successful synthesis and chelation process, alongside the demonstrated selectivity and high capacity of the sorbent, underscores the polymer's utility in addressing the challenge of removing heavy metals from aqueous solutions. © 2024 Society of Chemical Industry (SCI).
Kern's six‐step approach allows for meaningful implementation of an orthognathic surgery training course
Authors: Tan Kian How , Yong Chee Weng , Wong Raymond Chung Wen 
Published: April 2024

AbstractObjectivesThis study investigated the effectiveness of simulation training in improving the confidence and competency of oral and maxillofacial surgery (OMS) residents in performing orthognathic surgery (OGS).MethodsKern's six‐step approach was applied when designing the simulation training for OMS residents. The difficulties encountered by the residents when learning OGS were considered when designing the training program. A training course consisting of didactic sessions, hands‐on training on three‐dimensional training models, and an assessment tool was implemented for OMS residents. Improvement in the confidence and competence of OMS residents in performing OGS, fidelity of the three‐dimensional models, and satisfaction with the course was evaluated.ResultsAll OMS residents (10/10) completed the course. The perceived difficulty in learning OGS was mainly related to the manipulation of the jawbones. While there were improvements in the median confidence and competence scores (3/5 to 4/5), only the differences in competence were found to be statistically significant (p < 0.01, Wilcoxon signed‐rank test). Improvements in confidence and competence did not correlate. The mean fidelity scores of both the maxillary and mandibular models were adequate at 3.2 out of 5. Overall, satisfaction with the course was high (5/5).ConclusionsThe six‐step approach provides a guided process for educators to formulate a training course directed toward the perceived needs of students. Targeted training can significantly enhance the students’ competence. Greater efforts should also be put in place to allow simultaneous developments in the students’ confidence along with their competence.
Evaluating dental student self‐assessment across preclinical anatomy waxing and operative exercises
Authors: Liang Lang , Lin Amy J. , Ha Vivian , Chutinan Supattriya , Ohyama Hiroe 
Published: April 2024

AbstractPurpose/objectiveA career in healthcare is built on the foundations of continuous self‐reflection and self‐assessment. Previous studies have solely compared student self‐assessment to faculty grades in a single discipline. The objective of this study was to investigate whether associations of a student's self‐assessment skills exist across multiple disciplines in the predoctoral setting.MethodsSixty‐five students from two class years at the Harvard School of Dental Medicine completed preclinical competency exams in dental anatomy waxing and operative dentistry. The difference between the student's self‐assessment score and average faculty grade for each exercise was calculated as the student‒faculty (S‐F) gap, which served as a proxy to determine how students evaluate their work. Regression analysis was performed to assess associations between wax‐up and preclinical operative S‐F gaps.ResultsMean S‐F gaps for waxing and preclinical operative procedures were positive (5.7 ± 6.1 and 7.6 ± 6.7, respectively). Additionally, students in the lower quartile tended to overestimate performance to a greater degree than their peers in the upper quartile. Furthermore, the waxing S‐F gaps were positively associated with S‐F gaps of each operative procedure, particularly with the combined operative exercise S‐F gaps, where a statistically significant association was seen (coefficient = 0.28; p = 0.04).Conclusion(s)Previously, we identified a negative correlation between students' self‐assessment skills (S‐F gaps) and their preclinical performance. In this study, we further demonstrated an association of S‐F gaps in two fundamental exercises: wax‐up and operative dentistry. This underscores the roles of S‐F gaps as possible indicators of students’ preclinical and clinical performance, and it holds potential to become a widely standardized and applicable calculation that may help evaluate the effectiveness of the dental curricula and optimize student learning.
院外心停止患者に対するコロナ禍での診療方針変更の転帰への影響(Impact of a change in treatment strategy on outcomes of out–of–hospital cardiac arrest patients during the COVID–19 pandemic)
Authors: 史明 岩瀬 , 善史 宮﨑 , 学 松本 , 政彦 柳沢 , 将継 笹本 , 督司 池田 , 一樹 萩原 
Published: April 2024

要旨【目的】2019年12月に発生した新型コロナウイルス感染症（COVID–19）の流行を機に変更した院外心停止患者に対する診療方針の変更が妥当であったか検討すること。【方法】COVID–19期とコロナ禍前の同様の期間をCOVID–19前期として両期間に山梨県立中央病院高度救命救急センター（以下，当センター）へ搬送された院外心停止患者を検討対象とし，後方視的に患者背景，治療内容，予後を比較検討した。【結果】COVID–19前期840例，COVID–19期993例の1,833例が検討対象となった。病院前診療はCOVID–19期で有意に減少した。消防の覚知から救急隊の現場到着までの時間は8分から9分，病院到着までの時間も37分から39分と有意に延長した。病院到着後の心拍再開率は33%から21%へと減少し，入院率も23%から13%へ減少した。生存退院は6%と5%，神経学的予後良好も4%と4%であり，両期間に有意差は認めなかった。【結語】当センターに搬送された院外心停止はコロナ禍では，救急隊の現場到着が遅延し病院到着までの時間も延長していた。病院前診療が減少し心拍再開率，入院率は減少したが，生存退院，神経学的予後良好の割合は同等を維持していた。当センターのCOVID–19期の蘇生中止基準は妥当だったと考える。
Virtual MOLLI Target: Generative Adversarial Networks Toward Improved Motion Correction in MRI Myocardial T1 Mapping
Authors: Pan Nai‐Yu , Huang Teng‐Yi , Yu Jui‐Jung , Peng Hsu‐Hsia , Chuang Tzu‐Chao , Lin Yi‐Ru , Chung Hsiao‐Wen , Wu Ming‐Ting 
Published: April 2024

BackgroundThe modified Look‐Locker inversion recovery (MOLLI) sequence is commonly used for myocardial T1 mapping. However, it acquires images with different inversion times, which causes difficulty in motion correction for respiratory‐induced misregistration to a given target image.HypothesisUsing a generative adversarial network (GAN) to produce virtual MOLLI images with consistent heart positions can reduce respiratory‐induced misregistration of MOLLI datasets.Study TypeRetrospective.Population1071 MOLLI datasets from 392 human participants.Field Strength/SequenceModified Look‐Locker inversion recovery sequence at 3 T.AssessmentA GAN model with a single inversion time image as input was trained to generate virtual MOLLI target (VMT) images at different inversion times which were subsequently used in an image registration algorithm. Four VMT models were investigated and the best performing model compared with the standard vendor‐provided motion correction (MOCO) technique.Statistical TestsThe effectiveness of the motion correction technique was assessed using the fitting quality index (FQI), mutual information (MI), and Dice coefficients of motion‐corrected images, plus subjective quality evaluation of T1 maps by three independent readers using Likert score. Wilcoxon signed‐rank test with Bonferroni correction for multiple comparison. Significance levels were defined as P < 0.01 for highly significant differences and P < 0.05 for significant differences.ResultsThe best performing VMT model with iterative registration demonstrated significantly better performance (FQI 0.88 ± 0.03, MI 1.78 ± 0.20, Dice 0.84 ± 0.23, quality score 2.26 ± 0.95) compared to other approaches, including the vendor‐provided MOCO method (FQI 0.86 ± 0.04, MI 1.69 ± 0.25, Dice 0.80 ± 0.27, quality score 2.16 ± 1.01).Data ConclusionOur GAN model generating VMT images improved motion correction, which may assist reliable T1 mapping in the presence of respiratory motion. Its robust performance, even with considerable respiratory‐induced heart displacements, may be beneficial for patients with difficulties in breath‐holding.Level of Evidence3Technical EfficacyStage 1
A statistical method for the attribution of change‐points in segmented Integrated Water Vapor difference time series
Authors: Nguyen Khanh Ninh , Bock Olivier , Lebarbier Emilie 
Published: April 2024

AbstractMany segmentation or change‐point detection methods for homogenizing climate time series compare candidate station data with reference data to eliminate common climate signals and more efficiently detect spurious, non‐climatic changes. One drawback is that it is difficult to decide whether the detected change‐point is due to the candidate series or to the reference. A so‐called attribution procedure is typically applied in a post‐processing step for each detected change‐point. This article describes a new statistical method for the attribution of change‐points detected in Global Navigation Satellite System (GNSS) minus reanalysis series of integrated water vapour. It requires at least one nearby station with similar GNSS and reanalysis data. Six series of differences are formed from the four base series (BS) and are tested for a significant jump at the time of the change‐point detected in the candidate station. The six test results are analysed with a statistical predictive rule to attribute the change‐point to one, or several, of the four BS. Original aspects of our method are: (1) the significance test, which is based on a generalized linear regression approach, taking both heteroscedasticity and autocorrelation into account; (2) the predictive rule, which uses a machine learning method and is constructed from the test results obtained with the real data by using a resampling strategy. Four popular machine learning methods have been compared using cross‐validation and the best one was applied to a real data set (49 main stations with 114 change‐points). The results depend on the choice of the test significance level and the aggregation method combining the prediction results when several nearby stations are available. We find that 62% of the change‐points are attributed to GNSS, 19% to the reanalysis, and 10% are due to coincident detections.
Evaluation of acceptance and preference of topical lidocaine application versus articaine injection anesthesia after nonsurgical periodontal treatment: A randomized clinical trial
Authors: Dörfer Christof , Chmiela Kathrin , Arweiler Nicole B. , Petersilka Gregor J. , Dommisch Henrik , Heckel Ralph , Kahl Maren , Kuzmanova Denica , Purucker Peter , Springer Claudia 
Published: April 2024

AbstractBackgroundTo compare acceptance and preference of topical lidocaine gel anesthesia with articaine injection anesthesia in patients with moderate periodontitis undergoing scaling and root debridement.MethodsNinety‐one patients completed this randomized multicenter split‐mouth controlled study and underwent two separate periodontal treatment sessions on different days, one with a topical intrapocket lidocaine gel application and the other with an articaine injection anesthesia in a different order depending on randomization. Parameters measured were the patients’ preference for topical lidocaine gel anesthesia or injection anesthesia with articaine (primary efficacy criterion), their maximum and average pain, and their intensity of numbness as well as experience of side effects; the probing depth; and the dentists’ preference and their evaluations of handling/application, onset and duration of anesthetic effect, and patient compliance.ResultsAfter having experienced both alternatives, 58.3% of the patients preferred the topical lidocaine gel instillation into the periodontal pockets. The safety profile of the lidocaine gel differed positively from the safety profile of articaine injection in type and frequency of adverse drug reactions. The dentistsʼ acceptance and preference regarding either anesthetic method studied were balanced.ConclusionsInstillation of lidocaine gel into the periodontal pocket is a preferred alternative to injection anesthesia for most of the patients and an equivalent alternative for dentists in nonsurgical periodontal therapy.
Optical penetration models for practical prediction of femtosecond laser ablation of dental hard tissue
Authors: Woodfield Peter L. , Rode Andrei V. , Dao Dzung , Dau Van Thanh , Madden Steve , Walsh Laurence J. , Spallek Heiko , Walsh Lee , Sutton Andrew J. , Zuaiter Omar , Habeb Alaa , Hirst Timothy R. , Rapp Ludovic 
Published: April 2024

AbstractObjectivesTo develop and practically test high‐precision femtosecond laser ablation models for dental hard tissue that are useful for detailed planning of automated laser dental restorative treatment.MethodsAnalytical models are proposed, derived, and demonstrated for practical calculation of ablation rates, ablation efficiency and ablated morphology of human dental enamel and dentin using femtosecond lasers. The models assume an effective optical attenuation coefficient for the irradiated material. To achieve ablation, it is necessary for the local energy density of the attenuated pulse in the hard tissue to surpass a predefined threshold that signifies the minimum energy density required for material ionization. A 1029 nm, 40 W carbide 275 fs laser was used to ablate sliced adult human teeth and generate the data necessary for testing the models. The volume of material removed, and the shape of the ablated channel were measured using optical profilometry.ResultsThe models fit with the measured ablation efficiency curve against laser fluence for both enamel and dentin, correctly capturing the fluence for optimum ablation and the volume of ablated material per pulse. The detailed shapes of a 400‐micrometer wide channel and a single‐pulse width channel are accurately predicted using the superposition of the analytical result for a single pulse.ConclusionsThe findings have value for planning automated dental restorative treatment using femtosecond lasers. The measurements and analysis give estimates of the optical properties of enamel and dentin irradiated with an infrared femtosecond laser at above‐threshold fluence and the proposed models give insight into the physics of femtosecond laser processing of dental hard tissue.
The interplay between blockchain adoption and green operations for a firm
Authors: Zhang Huanyong , Zhu Chenchen , Zhang Wen 
Published: April 2024

AbstractThis study considers a firm selling only green products or both ordinary and green ones to consumers with or without blockchain technology. We find that the profitability of adoption of this technology for the firm relies heavily on consumers' environmental awareness. It should be adopted when consumers have relatively high environmental awareness. Here, the selling price, sales, and greenness level of green products are relatively higher compared to those in the case without blockchain. Finally, the firm only sells green products after blockchain adoption when consumers' environmental awareness level is relatively high or the development cost coefficient of green products is relatively small.
Effect of ferrous, nickel, and tungsten fillers reinforcement on glass fiber reinforced vinyl ester/polyester composites
Authors: Hemath Mohit , Rangappa Sanjay Mavinkere , C Pandi Selvan Durai , Ramesh Periyasamy , Siengchin Suchart , Al‐Romaizan Abeer Nasser , Hussein Mahmoud A. , Khan Anish , Asiri Abdullah M. , Althomali Raed H. 
Published: April 2024

AbstractThe present investigation targets the physical, mechanical, and thermal characteristics of glass fabric‐reinforced vinyl ester/polyester hybrid laminates filled with ferrous, nickel, and tungsten micro‐particles. The metal‐fillers‐glass fabric reinforced vinyl ester/polyester hybrid composites was produced by distributing 1 wt% ferrous, nickel, and tungsten with an ultrasonication probe‐assisted wet layup method. Polyester resin reinforced with glass fabrics and tungsten fillers (PRGT) presents improved mechanical characteristics compared with other hybrid laminates, with tensile, compression, and flexural strength values of 157.89 MPa, 163.74 MPa, and 167.29 MPa, respectively. The fractographic microstructure of tensile fracture PRGT laminates exhibits that glass fibers pull out, microcracks, and lower gaps, because of stronger filler‐fabric‐matrix adhesion when compared with other hybrid laminates. The artificial neural network modeling was conducted to choose the best composite among the various manufactured composites. Statistical analysis was observed from the one‐way ANOVA technique, substantiating that the physical, mechanical, and thermal characteristics of metal fillers‐reinforced hybrid composites were statistically significant.Highlights
Metal‐fillers‐glass fabric reinforced vinyl ester/polyester hybrid composites.
Selection of the best composite from developed composites by ANN.
Tungsten fillers are a useful material for reinforcement.
Association between mental health social worker staffing in psychiatric emergency wards and readmission outcomes: A nationwide survey in Japan
Authors: Suzuki Kosuke , Niitsu Tomihisa , Kimura Hiroshi , Yanagisawa Yuta , Ono Marina , Komatsu Hideki , Yoshimura Kensuke , Watanabe Hiroyuki , Iyo Masaomi 
Published: April 2024

AbstractAimThe mental healthcare system in Japan is transitioning from institution‐based to community‐based treatment. To prevent prolonged hospitalization and community integration of psychiatric patients, mental health social workers (MHSWs) are pivotal in coordinating post‐discharge arrangements for psychiatric inpatients. This study aimed to propose a care model to improve clinical outcomes in psychiatric emergency wards in Japan.MethodsWe conducted a mail‐in questionnaire survey targeting medical facilities with psychiatric emergency wards. We collected data of the psychiatric care system, including facility profiles, staffing conditions and caseloads, and the provided psychiatric services and treatment options. Using multiple regression analyses, we explored associations between these data and clinical outcomes, focusing on the average number of days for hospitalization and the integration of patients into a community.ResultsData were collected from 82 facilities (response rate, 45.8%). The average number of days for hospitalization and community integration were 64.7 and 327.9 days, respectively. The caseloads for MHSWs were significantly associated with longer hospitalization (β = 0.31, p = 0.009) and shorter duration of community living (β = −0.28, p = 0.027).ConclusionThe clinical performance in psychiatric emergency wards surpassed the Japanese government's targets regarding these outcomes. We found that heavy caseloads on MHSWs were associated with worse clinical outcomes for patients in psychiatric emergency wards. These findings suggest that reducing MHSW caseloads (≤20 cases) may be a potential interventional strategy to prevent prolonged hospitalization and promote successful community integration of patients.