bluuebunny/crossref_metadata_2025_split huggingface dataset:
Eubacterium rectaleis a potential marker of altered gut microbiota in psoriasis and psoriatic arthritis
Authors: Xiao Yue , Wang Yiyi , Tong Bangzhuo , Gu Yuanxia , Zhou Xingli , Zhu Ning , Xu Xiaomin , Yin Xiaochen , Kou Yan , Tan Yan , Wang Jincheng , Li Wei 
Published: March 2024

ABSTRACTPrevious studies have profiled the gut microbiota among psoriatic patients compared to that among healthy individuals. However, a comprehensive understanding of the magnitude, direction, and detailed compositional and functional profiles remains limited. Additionally, research exploring the gut microbiota in the context of both plaque psoriasis (PsO) and psoriatic arthritis (PsA) is lacking. To assess the taxonomic and functional characteristics of the gut microbiota in PsO and PsA patients and investigate potential links between the gut microbiota and disease pathogenesis. We collected fecal samples from 70 psoriatic patients (44 PsO and 26 PsA) and 25 age- and gender-matched healthy controls (HC) and employed deep metagenomic sequencing to characterize their gut microbiota. We noted significant alternations in the gut microbiota compositions of both PsO and PsA patients compared to those of HC. Despite limited effect sizes in alpha diversity (12.3% reduction of microbial richness but unchanged evenness in psoriatic patients) and beta diversity (disease accounts for 3.5% of total variations), we consistently observed substantial reductions ofEubacterium rectalein both PsO and PsA patients, with PsA patients exhibiting even lower levels ofE. rectalethan PsO patients. Additionally, twoAlistipesspecies were also depleted in psoriatic patients. These microorganisms are known to play crucial roles in carbohydrate metabolism pathways, mainly producing short-chain fatty acids with anti-inflammatory effects. Overall, our observations supplemented the profiling of altered gut microbiota in patients with PsO and PsA at the species level and described a link between the dominant short-chain fatty acid-producing bacterial species and systemic immunity in psoriatic patients.IMPORTANCEIn this observational clinical study with sufficient sample size and metagenomic sequencing to profile the gut microbiota, we identified consistent signals of the depleted abundance ofEubacterium rectaleand related functional genes among psoriatic patients, including those with psoriatic arthritis.E. rectalemay serve as an ecologically important functional unit in the gut microbiota, holding potential as a diagnostic marker and target for therapeutic interventions to achieve lasting effects. Our findings provide comprehensive gut microbiota profiling in psoriasis, resolving previous contradictions and generating new hypotheses for further investigation. These insights may significantly impact psoriasis management and related conditions.
Outcomes following the adoption of standard parenteral nutrition in preterm infants: a whole-population non-concurrent control study
Authors: Burgess-Shannon Jessica , Chehrazi Mohammad , Lanoue Julia , Modi Neena , Uthaya Sabita N 
Published: March 2024

ObjectiveTo evaluate the impact of a quality improvement project of the adoption of standard parenteral nutrition (SPN) in preterm infants.DesignRetrospective, multicentre, whole-population, non-concurrent control study using data from the UK National Neonatal Research Database between 1 January 2014 and 31 December 2020.SettingNeonatal units in London UK organised by geographical network.PatientsPreterm infants <31 weeks’ gestation.InterventionsIntroduction of two SPN formulations previously tested in randomised controlled trials (NEON and SCAMP). SCAMP delivers a higher target macronutrient intake.Main outcome measuresThe primary outcome was survival to discharge from neonatal care without major morbidities. Secondary outcomes included the individual components of the primary outcome and a comparison of outcomes between the NEON and the SCAMP formulations.ResultsOf 6538 eligible infants, 4693 were admitted to neonatal care before and 1845 after the adoption of SPN. Morbidity-free survival decreased by an average of 8.6% (95% CI 5.8% to 11.4%, p<0.0001) following adoption. The effect varied by type of formulation; the cohort that adopted NEON showed no difference in morbidity-free survival, whereas the cohort that adopted SCAMP showed a statistically significant decrease in morbidity-free survival. Overall survival decreased by an average of 2.0% (95% CI 0.01% to 4.0%, p=0.048).ConclusionsResearch is urgently needed to identify the optimal composition of parenteral nutrition for preterm babies. This study also adds to the growing body of evidence that suggests that early and high intakes of macronutrients in preterm babies may be harmful.
Clinical and angiographic characteristics of ruptured and unruptured distal cerebral aneurysms: a review of a large series of cases in a high-volume center
Authors: Cao Roberta , Mattar Adonis , Torche Esteban , Riva Roberto , Laubacher Morgane , Moreno-Gomez Ricardo , Turjman Francis , Falini Andrea , Panni Pietro , Eker Omer F 
Published: March 2024

Objective
To evaluate clinical, angiographic features, and endovascular approach of ruptured and unruptured distal intracranial aneurysms (DIAs).

Methods
From January 2013 to February 2022, details of all consecutive intracranial aneurysms (IAs) treated endovascularly in our center were collected and retrospectively reviewed. IAs involving the anterior cerebral artery, middle cerebral artery, and posterior cerebral artery (distal to anterior communicating artery, limen insula, and P1 segment, respectively), and those distal to superior cerebellar artery, anterior–inferior cerebellar artery, and posterior inferior cerebellar artery's first segment were classified based on their etiology, location, size, and shape. Demographic, clinical, angiographic, and procedural variables, as well as follow-up outcomes were evaluated.

Results
Of 2542 IAs, 151 (5.9%) DIAs were counted (average size 5.4±2.9 mm), including 61 (40.4%) unruptured and 90 (59.6%) ruptured. No difference in the aneurysmal size was observed, but aneurysms smaller than 4 mm were observed more frequently in the ruptured group (36.7% vs 18%; P=0.01). In addition, ruptured DIAs were more often non-saccular (40% vs 18%; P=0.004) and irregular (93.3% vs 59%; P<0.001), They were treated mostly by coiling, glue, and parent artery sacrifice (P=0.02, P=0.006, and P=0.001), whereas unruptured DIAs were treated by stent-assisted coiling and flow-diverter stents (P=0.001 and P<0.001, respectively), without any differences in occlusion (81.6% vs 82.5%) and recanalization (21.1% vs 17.5%) rates. Procedure-related complications occurred in 20/151 (13.2%) patients, without any differences between subgroups. Ruptured DIAs were more often re-treated (18.4% vs 5.3%, P=0.02). In multivariate analyses, irregular shape appeared as an independent predictor of ruptured presentation (OR=8.1, 95% CI 3.0 to 21.7; P<0.001).

Conclusions
Compared with unruptured DIAs, ruptured DIAs were more often non-saccular, irregular, and smaller than 4 mm. Despite different therapeutical approaches, ruptured and unruptured DIAs presented comparable occlusion and recanalization rates.
Crystallization of mixtures of local anesthetics with and without select adjuvants: a semiquantitative light microscopy analysis
Authors: Hoerner Elisabeth , Stundner Ottokar , Seisl Anna , Fiegl Heidi , Gasteiger Lukas 
Published: March 2024

Introduction
Injecting mixtures of local anesthetics with or without adjuvants is a common practise in regional and particularly obstetric anesthesia to decrease block onset time and/or augment epidural analgesia for cesarean section. While evidence on the efficacy of this practise is equivocal, little is known about its safety in terms of the pharmacologic compatibility of local anesthetics.

Methods
We assessed the grade of crystallization in individual mixtures of seven local anesthetics (bupivacaine, ropivacaine, lidocaine, procaine, chloroprocaine, mepivacaine, prilocaine) with or without four adjuvants (sodium bicarbonate, dexamethasone, clonidine, fentanyl) using a semiquantitative light microscopy scale (ranging from 0 to 5), repeatedly for up to 60 min and performed correlation analysis between grade of crystallization and initial solution pH.

Results
Of the 50 mixtures tested, 26 showed grades of crystallization ≥4 at admixture and 41 showed grades of crystallization ≥4 after 60 min. The addition of adjuvants to local anesthetic mixtures did not substantially change the grades of crystallization. Bupivacaine has a slightly lower precipitation tendency, compared with ropivacaine. A moderate relationship was found between initial pH and grade of crystallization after 15 min for the adjuvant mixtures (R=0.33, p=0.04), but not at other time points.

Discussion
The preparation of local anesthetic (±adjuvant) mixtures leads to high grades of crystallization, which increase over 60 min and appear independent of solution pH. The risk of mixing medications with unknown physical or chemical compatibility profiles in regional anesthesia should be critically appraised and its clinical significance elucidated in future translational research.
DONGLE 2.0: Direct FPGA-Orchestrated NVMe Storage for HLS
Authors: Wong Linus Y. , Zhang Jialiang , Li Jing 
Published: March 2024

Rapid growth in data size poses significant computational and memory challenges to data processing. FPGA accelerators and near-storage processing have emerged as compelling solutions for tackling the growing computational and memory requirements. Many FPGA-based accelerators have shown to be effective in processing large data sets by leveraging the storage capability of either host-attached or FPGA-attached storage devices. However, the current HLS development environment does not allow direct access to host-or FPGA-attached NVMe storage from the HLS code. As such, users must frequently hand off between HLS and host code to access data in storage, and such a process requires tedious programming to ensure functional correctness. Moreover, since the HLS code uses radically different methods to access storage compared to DRAM, the HLS codebase targeting DRAM-based platforms cannot be easily ported to NVMe-based platforms, resulting in limited code portability and reusability. Furthermore, frequent suspension of HLS kernel and synchronization between CPU and FPGA introduce significant latency overhead and require sophisticated scheduling mechanisms to hide latency.

To address these challenges, we propose a new HLS storage interface named DONGLE 2.0 that enables direct FPGA-orchestrated NVMe storage access. By providing a unified interface for storage and memory access, DONGLE 2.0 allows a single-source HLS program to target multiple memory/storage devices, thus making the codebase cleaner, portable, and more efficient. DONGLE 2.0 is an extension to DONGLE 1.0 [
1
] but adds support for host-attached storage. While its primary focus is still on FPGA NVMe access in near-storage configurations, the added host storage support ensures its compatibility with platforms that lack native support for FPGA-attached NVMe storage. We implemented a prototype of DONGLE 2.0 using an AMD/Xilinx Alveo U200 FPGA and Solidigm DC-P4610 SSD. Our evaluation on various workloads showed a geometric mean speed-up of 2.3× and a reduction in lines of code (LoC) by 2.4× compared to the state-of-the-art commercial platform when using FPGA-attached NVMe storage. Moreover, DONGLE 2.0 demonstrated a geometric mean speed-up of 1.5× and a reduction in LoC by 2.4× compared to the state-of-the-art commercial platform when using host-attached NVMe storage.
Mesenchymal Stem/Stromal Cell Therapy for Radiation-Induced Xerostomia in Previous Head and Neck Cancer Patients: A Phase II Randomized, Placebo-Controlled Trial
Authors: Jakobsen Kathrine Kronberg , Carlander Amanda-Louise Fenger , Todsen Tobias , Melchiors Jacob , Paaske Natasja , Østergaard Madsen Anne Kathrine , Kloch Bendtsen Simone , Mordhorst Christine , Stampe Helene , Kastrup Jens , Ekblond Annette , Haack-Sørensen Mandana , Farhadi Mohammad , Maare Christian , Friborg Jeppe , Lynggaard Charlotte D. , Werner Hauge Anne , Christensen Robin , Grønhøj Christian , von Buchwald Christian 
Published: March 2024

Abstract

Purpose:
No effective treatment exists for radiation-induced xerostomia. The objective of this study was to compare the effect of adipose-derived mesenchymal stem/stromal cell (ASC) injection, relative to placebo, on salivary gland function in patients with radiation-induced xerostomia.

Patient and Methods:
In this single-centre, double-blind, placebo-controlled trial, patients with hyposalivation were randomised to receive ultrasound-guided injections of allogeneic ASCs or placebo into the submandibular glands. Patients were followed for 4 months. We evaluated unstimulated whole salivary flow rate (UWS), stimulated salivary flow rate, and patient-reported outcomes. Adverse events were recorded and immune response determined in blood samples.

Results:
We enrolled 120 patients. ASC treatment resulted in a statistically significant UWS increase of 0.04 [95% confidence interval (CI), 0.02–0.06] mL/min (38%) compared with pretreatment baseline whereas placebo treatment did not cause a significant increase [0.01 (95% CI, −0.01 to 0.04) mL/min (21%)]. Both the ASC and placebo treatment yielded notable symptom reductions, with dry mouth decreasing by 13.6 and 7.7 units, sticky saliva decreased by 14.8 and 9.3 units, swallowing difficulties decreased by 7.9 and 8.0 units, and the summary score of the Xerostomia Questionnaire decreased 5.9 and 5.1 units for the ASC and placebo arms, respectively. We found no statistically significant group difference between the ASC and placebo arms for any of the outcomes.

Conclusions:
We could not confirm superiority of the ASC relative to placebo. ASC therapy significantly improved UWS in previous patients with head and neck cancer, whereas placebo resulted in an insignificant increase.
Low- and High-Grade Glioma-Associated Vascular Cells Differentially Regulate Tumor Growth
Authors: Muthukrishnan Sree Deepthi , Qi Haocheng , Wang David , Elahi Lubayna , Pham Amy , Alvarado Alvaro G. , Li Tie , Gao Fuying , Kawaguchi Riki , Lai Albert , Kornblum Harley I. 
Published: March 2024

Abstract

A key feature distinguishing high-grade glioma (HG) from low-grade glioma (LG) is the extensive neovascularization and endothelial hyperproliferation. Prior work has shown that tumor-associated vasculature from HG is molecularly and functionally distinct from normal brain vasculature and expresses higher levels of protumorigenic factors that promote glioma growth and progression. However, it remains unclear whether vessels from LG also express protumorigenic factors, and to what extent they functionally contribute to glioma growth. Here, we profile the transcriptomes of glioma-associated vascular cells (GVC) from IDH-mutant (mIDH) LG and IDH-wild-type (wIDH) HG and show that they exhibit significant molecular and functional differences. LG-GVC show enrichment of extracellular matrix–related gene sets and sensitivity to antiangiogenic drugs, whereas HG-GVC display an increase in immune response–related gene sets and antiangiogenic resistance. Strikingly, conditioned media from LG-GVC inhibits the growth of wIDH glioblastoma cells, whereas HG-GVC promotes growth. In vivo cotransplantation of LG-GVC with tumor cells reduces growth, whereas HG-GVC enhances tumor growth in orthotopic xenografts. We identify ASPORIN (ASPN), a small leucine-rich repeat proteoglycan, highly enriched in LG-GVC as a growth suppressor of wIDH glioblastoma cells in vitro and in vivo. Together, these findings indicate that GVC from LG and HG are molecularly and functionally distinct and differentially regulate tumor growth.
Implications: This study demonstrated that vascular cells from IDH-mutant LG and IDH-wild-type HG exhibit distinct molecular signatures and have differential effects on tumor growth via regulation of ASPN-TGFβ1-GPM6A signaling.
Christ’s Cosmetic Hydrotherapy: Blemishes, Wrinkles, and Transformational Waters in Ephesians 5:26–27
Authors: Soon Isaac T. 
Published: March 2024

Abstract
This article argues that the washing that removes blemishes and wrinkles in Eph 5:26–27 is intelligible against wider ancient Graeco-Roman and early Christian conceptions of transformational waters. Ancient Mediterranean traditions tell of special waters that change human skin complexion, prolong life, and remove impairment. Ancient Graceo-Roman medicine indicates that for many women in the Mediterranean, blemishes such as freckles and wrinkles were non-ideal epidermal conditions that women tried to cover up and/or remove through various topical substances and applications. In light of this context, Christ’s washing of the church can be viewed as a cosmetic hydrotherapy designed to remove undesirable blemishes and wrinkles and conform the body to an ideal youthful female complexion, which the author equates with holiness. Christ is the church’s cosmetological kyrios, transforming his household into the ideal physique by washing them. The wider Mediterranean culture concerning women and transformative waters is not only background material that makes intelligible the bathing in Eph 5:26–27 but it shows the household code’s participation in what Margaret MacDonald calls “ideologies of masculinities.” Whatever cultural modifications or progressive advancements might be found in the household code, the Ephesian author’s use of the metaphor of Christ washing the bride fundamentally enshrines the control a husband has over his wife’s body. While the author of Ephesians portrays Christ’s cosmetic hydrotherapy as dealing primarily with sin, because it is embedded within a wider discourse about gender, it is also a transformative water that reinforces and bends the gender of early Christian believers.
The Matter of Violence
Authors: Dawson Cindy 
Published: March 2024

Abstract
This article analyzes violence against the body of Woman Jerusalem in Ezek. 16 and 23 from a New Materialist perspective. As a methodology, New Materialism forges new paths when considering the female body and agency: namely, literal and literary bodies possess the ability to transform their literal and literary worlds, even when—especially when—these bodies become entangled in violent acts. This article therefore considers Woman Jerusalem’s violated body from two perspectives. The first is the perspective of Ezekiel-the-exiled-priest and the centrality of Woman Jerusalem’s body in his theological project of identity building. The second is the perspective of Ezekiel-the-iconoclast and the ability of Woman Jerusalem’s body to survive his acts of violence and reemerge as an intercessor. Such continuity has profound significance for the evolving Zion tradition, which follows the body of Woman Jerusalem to the other side of exile and there reconsiders the relationship between Yahweh, Jerusalem, and her human inhabitants.
The Holistic Effects of Mystical Union with Christ in the Soteriology of Dhanjibhai Fakirbhai
Authors: Burbank Ray 
Published: March 2024

Abstract
This article addresses the relationship between eschatological and present issues in Christian soteriological debates of the mid-twentieth century, particularly in post- colonial India. It focuses on the writings of Dhanjibhai Fakirbhai. As mystical views of Christian salvation can be criticized for their irrelevancy to secular society, Dhanjibhai presents a contrast to this in a type of mystical soteriology that breaks such critiques and complicates the usual categories of South Asian understandings. According to Dhanjibhai, “salvation” means to be in union with Jesus Christ, a spiritual faith-based relationship that extends into eternity but is also practically experienced in the world today. This article proceeds according to four key features of Dhanjibhai’s writings that demonstrate the holistic effects of union with Christ in his soteriology. I argue that Dhanjibhai alleviates the perceived problems of mystical approaches by presenting a soteriology that envelopes personal, social, and even ecological ramifications of salvation within a contextual evangelical framework.
Prophetic Mediums
Authors: Crace Benjamin D. 
Published: March 2024

Abstract
This article seeks to develop an accommodationist theology of prophetic mediumship that critically incorporates ancestral presences. It argues that ancestral presence in the practice of prophecy can be supported by non-Western and non-Protestant theologies, scriptural evidence, experience, and the ecumenical church tradition. It suggests that mediumship is a helpful way of thinking about the prophetic while also maintaining a pluralistic pneumatology informed by intercultural theology. Such a theology, it is argued, can underwrite practice in which the experiential presence of holy spirits intensifies the evangelical proclamation of Christ’s victory over death and sin.
Inaugurated Eschatology within South African Pentecostalism
Authors: Kgatle Mookgo Solomon , Chigorimbo Joshua 
Published: March 2024

Abstract
Pentecostal eschatology differs from one sub-tradition of Pentecostalism to the other in a South African context. Sub-traditions such as classical Pentecostalism and the New Prophetic Churches (npc s) have been engaged in more than one form of eschatology. The differences are explored here to understand their implications for Pentecostal eschatology. The Pentecostal prophets in npc s do not exclusively focus on a futuristic eschatological approach as opposed to classical Pentecostalism. Pentecostal prophets in npc s embrace a realised eschatology of the kingdom in the here and the now. The challenge is that this approach presents some form of abuse in these churches. How do we address these abuses emanating from an overemphasised realised eschatology? How do we deal with the tensions between realised eschatology and futuristic eschatology? What could be the relevant eschatology that balances both extremes of a futuristic eschatology and realised eschatology? These questions are addressed here through an inaugurated eschatology.
Plotinus on the Parthood and Agency of Individual Souls
Authors: Kovács Dániel Attila 
Published: March 2024

Abstract
Plotinus criticizes the view that individual human souls are parts of the world-soul arguing that they would lack individual agency since their alleged actions would have to be attributed to the whole they are parts of (iii.1.4). He nevertheless holds that individual souls are parts of a larger whole, the so-called hypostasis soul, a soul that does not ensoul any body but encompasses and produces all individual souls including the world-soul (iv.3.4.14–21; iv.8.36–12; iv.9.5). In this paper, I ask whether Plotinus, in the face of his own arguments, can consistently attribute agency to individual souls and hold that they are parts of the hypostasis soul. I argue that Plotinus’ model of intelligible mereology (vi.2.20) allows individual souls to depend on the hypostasis soul as parts in a way that grounds their agency by providing them with the capacity for rational thought.
A Functionalist Account of Epicurus’ Minima
Authors: Martini Chiara 
Published: March 2024

Abstract
Epicurus’ original version of atomism takes atoms to be physically indivisible but not completely unanalysable: each atom contains a finite number of minima. This paper explores the nature of the minima by focusing on a specific question: in which sense are the minima minimal? I do so by investigating the notions of parthood and divisibility into parts that are at play in paragraphs 56–59 of the Letter to Herodotus, where the theory of minima is introduced. By focusing on the analogy (noticed by Francesco Verde) between Epicurean minima and Aristotelian limits, I argue that the minima should be understood as the minimal realiser of the atom’s physical functions. This allows me to keep together two very plausible but apparently incompatible claims: (i) the minima are supposed to block the paradoxes of theoretical divisibility, but (ii) their existence and their indivisibility can only be justified in physical (rather than geometrical) terms.