bluuebunny/crossref_metadata_2025_split huggingface dataset:
A multitaxa approach to biodiversity inventory in Matela protected area (Terceira, Azores, Portugal)
Authors: Sousa Mariana , Lamelas-López Lucas , Elias Rui , Gabriel Rosalina , Borges Paulo 
Published: April 2024

This manuscript is the first contribution of the project, “Matela – uma ilha de biodiversidade” (“Matela - an island of biodiversity”), that aims to restore the native vegetation within the Azorean Protected Area of the Terceira Island Nature Park known as the "Protected Area for the Management of Habitats or Species of Matela" (TER08), situated on Terceira Island, the Azores Archipelago, Portugal. This small fragment of native forest, positioned at a low-medium altitude (300-400 m a.s.l.), is facing some conservation impacts as a consequence of the spread of different invasive exotic plant species, mainly Pittosporum undulatum, Rubus ulmifolius and Hedychium gardnerianum. The database we present encompasses diverse taxonomic groups, including bryophytes, vascular plants, arthropods, birds and mammals. It is derived from intensive sampling campaigns conducted in 2022, but some data from a previous vascular plant survey in 2015 were also included. The objective of this study was to provide an updated inventory of bryophytes, vascular plants, arthropods, birds and mammals within this protected area. In this way we are providing the reference conditions necessary for the monitoring of the impacts of the current ongoing restoration efforts within the project “Matela - an island of biodiversity”. Whenever feasible, the present inventory is juxtaposed with historical data from previous surveys conducted in Matela.
In the realm of bryophytes, our analysis revealed the presence of 75 taxa, comprising 44 mosses and 32 liverworts. Amongst these, 71 were indigenous, while three remained indeterminate and one, Campylopus introflexus, was identified as invasive. A comparison with previous historical data revealed a decrease in species richness, which was partially counterbalanced by the discovery of 23 new recorded species in the area.
Regarding vascular plants, we distinguished 54 species, comprising 28 indigenous and 26 introduced taxa. Almost 80% of the inventoried species (n = 43) were newly documented in Matela.
The study of arthropods encompassed a total of 103 taxa. Within the realm of soil arthropods, we documented eight indigenous and 25 introduced taxa, witnessing the disappearance of endemic species alongside a substantial increase in introduced ones between 2002 and 2022. Canopy arthropods, totalling 36 indigenous and 18 introduced taxa, exhibited few changes when compared with data from 2002. SLAM traps captured 24 indigenous and 15 introduced arthropod taxa and no historical data are available for comparison.
As for avian species, we noted 12 indigenous birds and one introduced species, confirming the presence of most of the historical recorded native species.
The mammalian census revealed eight introduced species, setting new precedents for Matela, alongside the identification of one endemic species: the Azorean endemic bat Nyctalus azoreum.
Un exemple d’ouverture formelle à la transversalité : le droit des sociétés
Authors: Parachkevova-Racine Irina 
Published: April 2024

Il a toujours existé plusieurs façons d’enseigner le droit des sociétés. Le choix lui-même interroge profondément la vision que l’on a de l’enseignement du droit. Cette différence dans la façon d’enseigner n’est donc pas nouvelle. Ce qui est, en revanche, très nouveau est la transformation normative spectaculaire du droit des sociétés à l’aune de la transition écologique. De toutes les matières dans le giron des activités économiques, le droit des sociétés a été probablement le plus fortement écologisé au cours de ces dernières années. Une autre nouveauté change également la donne : les étudiants sont le pilier générationnel d’une opinion publique qui place dans l’entreprise des attentes nouvelles. Il ne fait aucun doute qu’il y a là un potentiel pour le renouvellement de l’enseignement du droit des sociétés. La question est de savoir comment ce potentiel peut être exploité. À l’évidence, la réponse dépend de l’enseignant et les difficultés sont importantes. Il est certain en même temps que cette écologisation est un terreau fertile pour un enseignement de droit économique, au sens d’école, susceptible de décloisonner la matière et de l’appréhender par une hauteur de vue stimulant la créativité nécessaire pour la manier.
TCF1highPD-1+Ly108+CD8+ T Cells Are Associated with Graft Preservation in Sensitized Mice Treated with Non–Fc Receptor–Binding CD3 Antibodies
Authors: Ota Takuji , Goto Ryoichi , Harada Takuya , Forgioni Agustina , Kanazawa Ryo , Ganchiku Yoshikazu , Kawamura Norio , Watanabe Masaaki , Fukai Moto , Shimamura Tsuyoshi , Taketomi Akinobu 
Published: April 2024

Abstract
The non–Fc-binding anti-CD3 Ab [anti-CD3F(ab′)2] can induce graft acceptance depending on the therapeutic window in a rodent heart transplant model. The delayed protocol allows for early graft infiltration of lymphocytes, which may behave in an inhibitory manner. We investigated the most effective protocol for anti-CD3F(ab′)2 in sensitized conditions to confirm the evidence for clinical application. C57BL/6 mice were sensitized with BALB/c tail skin grafts and transplanted with BALB/c heart grafts at 8–12 wk after sensitization. Fifty micrograms of anti-CD3F(ab′)2 was administered daily for 5 consecutive days on days 1–5 (day 1 protocol) or days 3–7 (delayed protocol). In nonsensitized mice, the delayed protocol significantly prolonged graft survival after transplantation from BALB/c to naive B6 (median survival time [MST], &gt;100 d). In contrast, the delayed protocol was unable to prevent graft rejection in sensitized mice (MST, 5 d). A significantly increased percentage of granzyme B+ CD8+ T cells was observed in the graft on day 3 posttransplantation in sensitized conditions. Further, the day 1 protocol significantly prolonged graft survival (MST, 18 d), even in sensitized conditions. Day 1 treatment significantly increased the percentage of Foxp3+CD25+CD4+ T cells and phenotypically changed CD8+ T cells in the graft (i.e., caused a significant increase in the proportion of Ly108+TCF1highPD-1+CD8+ T cells). In conclusion, different timings of delayed anti-CD3F(ab′)2 treatment promoted allograft preservation in association with phenotypic changes in CD4+ and CD8+ T cells in the graft under sensitized conditions.
Determination of Reference Interval for Serum Homocysteine, Magnesium, and Uric Acid from Tertiary Care Hospital Data By the Bhattacharya Method
Authors: Peter Monica , Bhaskar Arunachalam Vijaya , Kamble Videeta Avinash , Lazaras Gaikwad Abhishek , Christudoss Pamela , Varghese Joe , Venkatesan Padmanaban 
Published: April 2024

Abstract

Introduction:
Direct ways of establishing reference intervals for analytes are time-consuming and costly. Bhattacharya analysis is an indirect way to mathematically derive reference intervals from the results of analytes in a hospital database and is practically a simple and inexpensive alternative to direct methods.

Methods:
Data of serum uric acid, magnesium, and plasma homocysteine levels measured in the department of clinical biochemistry over 3 years were extracted from the hospital database along with the age, gender, and location of the patients. Bhattacharya analysis was performed by identifying underlying Gaussian distribution within the non-Gaussian distribution of the patient data by log transformation of the distribution of the data. Reference intervals for each of the analytes were calculated from the identified Gaussian distribution.

Results:
The reference interval for serum uric acid was 1.49–8.97 mg/dL in men and 2.13–6.14 in women, serum magnesium in adults was 1.19–3.21 mg/dL, and plasma homocysteine in adults was 4.6–21 μg/dL.

Conclusion:
Using Bhattacharya analysis, we were able to derive reference intervals for analytes from our hospital data.
Health of Tribal Population in India: A Glimpse of the Current Scenario
Authors: Linda Angel Ivy , Pal Debkumar , Murmu Nisha , Taywade Manish 
Published: April 2024

Abstract
Article 366(25) of the Indian constitution refers to indigenous people as “scheduled tribes,” which constitute 8.6% of the country’s population. For decades, the health of the tribal people had remained neglected and incorporated in rural health care because of incorrect assumptions of their similar health needs to that of the rural population. An expert committee coordinating with the Ministry of Health and Family Welfare and the Ministry of Tribal Affairs provided a detailed report on the current scenario and recommendations related to tribal health in India. They considered the health-care needs of the tribal population, highlighted their specific health problems, and gave a roadmap of best approaches. The tribal population has a unique and higher burden of health problems than the mainstream population, influenced by their health-seeking behavior, lack of awareness and education, sociocultural and magico-religious beliefs, customs, and practices. The current health-care system incorporates their health needs with approaches such as differing population norms in tribal areas, nonmonetary incentives to staff, mobile medical units, identification of high-priority districts, and the emergence of the “Swasthya” portal. However, tribal health is transitioning as with the rest of the population. Moreover, the present health-care services are unable to address this. Legal recognition of indigenous peoples’ rights to self-determination, their land, natural resources, and their knowledge is a need of the hour.
Dyke–Davidoff–Masson Syndrome – A Case Series
Authors: Sheetal S. , Sujan Joel Varghese , Das Athira , Mathai Vivek 
Published: April 2024

Abstract
Dyke–Davidoff–Masson syndrome (DDMS) refers to variable degrees of atrophy of one cerebral hemisphere, resulting from brain injury in intrauterine or early years of life. Clinical features of this rare syndrome include varying degrees of contralateral hemiplegia, facial asymmetry, seizures, and mental retardation. Specific neuroimaging findings include unilateral brain volume loss, ventriculomegaly, and compensatory bone hypertrophy. In addition to this, calvarial thickening and hyperpneumatization of frontal sinuses may occur. We hereby report three cases of this syndrome, with varied clinical and radiographic features, to highlight the wide spectrum of this syndrome.
Utility of Sensate Pedicled Medial Thigh Perforator Flaps in Treating Recurrent Ischial Ulcers in Individuals with Cauda Equina Lesions and Spinal Dysraphism – A Retrospective Analysis
Authors: Chalageri Prashanth H , Augustine Thomas Anand , Magimairaj Henry Prakash , Yadav Bijesh Kumar 
Published: April 2024

Abstract

Background:
Ischial pressure ulcers pose a significant challenge due to their high recurrence rates. It is imperative to provide or establish a reliable, well-vascularized soft-tissue cover over the ischial area to prevent recurrences. The objective of the study was to study the utility and complication rates associated with pedicled medial thigh perforator (P-MTP) sensate flap procedures in managing recurrent ischial ulcers and perineal lesions.

Methods:
A retrospective cohort study was conducted at Christian Medical College, Vellore, a tertiary care center in South India. This study involved 30 patients with ischial pressure sores. Of these, 13 patients underwent P-MTP flaps, while 17 underwent alternative surgeries for ulcer closure (January 2014–June 2020).

Results:
Among 13 patients who underwent P-MTP sensate flaps, 1 major complication (full-thickness flap necrosis) necessitated flap revision, while 6 minor complications occurred in the postoperative period. Three patients (23.08%) reported late recurrence of ulcers at the same postoperative site. In contrast, among the 17 patients who underwent the other (alternative) methods of surgical closure, 3 patients had wound dehiscence in the postoperative period. Four patients reported recurrence of ulcer at the postoperative site within 6 months and another four after 6 months of surgical closure. The surgical outcomes in sensate flap surgeries (P-MTP flaps) were comparable to other approaches for surgical closure. Sensation in the P-MTP flap transposed over the ischial region remained intact in all 13 patients at 6-month follow-up.

Conclusion:
The P-MTP sensate flap is a feasible and reliable treatment strategy for regional soft-tissue reconstruction in ischial and perineal lesions with postoperative complications comparable to other surgical methods for ischial ulcer closure. The sensate flap surgeries offer the additional benefit of maintaining intact sensation over the pressure injury vulnerable ischial region.
Prevalence of Depression, Anxiety, and Stress along with Coping Strategy and Work-related Sense of Coherence in Anesthesia Care Providers during the COVID-19 Pandemic in a Tertiary Care Hospital: A Cross-sectional Study
Authors: Jiwanmall Meghna , Joel Jerry Joseph , Williams Aparna , Jiwanmall Stephen Amarjeet , Kumar Bharath , Rai Ekta 
Published: April 2024

Abstract

Background:
Numerous studies have reported the prevalence of psychological issues in anesthesia professionals during stressful situations like the COVID-19 pandemic; however, there are limited data exploring the coping strategies and work satisfaction in this workforce during the pandemic.

Methodology:
In this observational cross-sectional study, three validated questionnaires, namely, the Depression, Anxiety and Stress Scale 21, the Brief-Coping Orientation to Problems Experienced inventory, and the Work-related Sense of Coherence (Work-SoC) scale, were handed out to 150 anesthesia health-care providers (doctors and allied health staff [AHS]). The prevalence of depression, anxiety, and stress; Work-SoC conditions; and coping strategies were compared between groups of participants based on age (<30 years vs. ≥30 years), gender (males vs. females), and occupation (doctors vs. AHS).

Results:
Participants aged <30 years reported more depression (P = 0.0134) and stress (P = 0.0453) compared to participants aged ≥30 years. Younger participants used emotion-focused and avoidant coping styles, whereas older participants used coping styles that were emotion focused and problem focused. Similarly, a problem-focused coping style was observed frequently among both doctors and AHS. Work-SoC assessment showed that younger participants (P = 0.0088) and more AHS respondents (P = 0.000) attributed poor meaningfulness, but doctors reported poor comprehensibility (P = 0.058) to their working conditions.

Conclusion:
Younger professionals were more susceptible to stress and depression during the pandemic. Similar to AHS, they perceived work conditions as unrewarding and less meaningful. Doctors perceived working conditions as unmanageable, unpredictable, and unstructured. There were age-related differences in coping strategies where older adults engaged in more proactive coping.
Concordance of breast cancer services in an urban tertiary care institute in India to EUSOMA guidelines: An audit of Indian breast cancer practices
Authors: Kadayaprath Geeta , Gupta Sandhya , Gupta Neerja 
Published: April 2024

Abstract
The provision of breast cancer care tends to vary substantially from one breast unit to another. To provide state-of-the-art patient-centered care to women diagnosed with breast cancer, adoption and adherence to structured treatment algorithms, protocols, and international guidelines are essential. In this review, we endeavor to audit breast cancer care at our tertiary cancer center against published EUSOMA guidelines. This was a retrospective study with an observational design. All patients who completed recommended treatment for breast diseases at our institute from January 1, 2018 to December 31, 2018 were included and evaluated. Data were retrieved from patient e-prescriptions and medical records. Analysis was performed using Microsoft Office 2010 to measure how our practices compared to EUSOMA quality indicators (QIs). Clinical assessments, imaging, and preoperative work-up of breast cancer patients met EUSOMA standards. Prognostic and predictive characterization of tumors was performed in all cases. Surgical management of invasive cancer and ductal carcinoma in situ (DCIS) was in accordance with the guidelines. Adherence to postoperative radiation and adjuvant endocrine therapy was adequate. More mastectomies were performed in patients with invasive cancers measuring <3 cm. Overtreatment was avoided in every other subgroup. Adjuvant and neoadjuvant chemotherapy and targeted adjuvant therapy were adequately utilized unlike neoadjuvant targeted therapy. Minimal attrition was noted in patient follow-up. This extensive audit has set a benchmark for future annual audits and helped highlight areas where improvement of service delivery is needed.
Comparative evaluation of bond strength of diode and neodymium-doped:Yttrium aluminum garnet-assisted bleached enamel with nanofilled composite: An in vitro study
Authors: Dube Ridhi , Tandale Anita , Talreja Twinkle Kishor , Krishnakumar Karishma , Kokate Prajakta , Mulay Sanjyot 
Published: April 2024

Abstract

Background:
The world of esthetic dentistry is constantly making efforts toward the management of tooth staining. Laser-assisted bleaching is needed before adhesive restorations and has become common and advantageous as it accelerates bleaching action, reduces postoperative sensitivity, and promotes recrystallization of enamel.

Aim:
The study aimed to evaluate and compare the bond strength of diode (Biolace: EpicX) and neodymium-doped:yttrium aluminum garnet (Nd:YAG) (LightWalker, Fotona, Slovenia) assisted bleached (Pola Office, SDI) enamel with nanofilled composite (GC Solare Sculpt).

Materials and Methods:
The samples were divided into three groups (n = 11): Group A – Conventionally bleached enamel, Group B – Diode laser-assisted bleached enamel, Group C – Nd:YAG laser-assisted bleached enamel. After storing samples in Artificial Saliva for 2 weeks, bonding was performed, and nanofilled composite resin was applied through an incremental method. Samples were subjected to shear bond strength (SBS) analysis.

Conclusion:
The use of Nd:YAG laser on bleached enamel significantly increases the bond strength with nanofilled composite resin.
Feasibility of opioid-free anesthesia in laparoscopic radical prostatectomy: A retrospective, quasi-experimental study
Authors: Tejedor Ana , Bijelic Lana , García Marta 
Published: April 2024

Abstract

Background and Aims:
Opioid-free anesthesia (OFA) provides adequate analgesia minimizing opioids. OFA has not been evaluated in laparoscopic radical prostatectomy (LRP). Our aim was to evaluate OFA feasibility and its effectiveness in LRP.

Material and Methods:
A quasi-experimental retrospective study of 55 adult patients undergoing LRP was performed from September 2020 until December 20223. Predefined protocols for either opioid-based anesthesia (OBA; with continuous remifentanil infusion) or OFA (continuous lidocaine, dexmedetomidine, and ketamine infusion) were followed. In both groups, wound infiltration was performed before skin incision. Primary outcome was postoperative pain management (numerical rating scale [NRS]) in the first 24 postoperative hours. Secondary outcomes were opioid consumption, start to sitting and ambulation, postoperative complications, and length of hospital stay.

Results:
OFA protocol patients had better median pain scores during movement at 1, 18 and 24 h, that is, 1 (interquartile range [IQR] 0–3) versus 2.5 (IQR 0–4), P = 0.047; 0 (IQR 0–1) versus 1 (IQR 0–2), P = 0.017; and 0 (IQR 0–0.25) versus 1 (IQR 0–2), P = 0.013, respectively. At 6 and 12 h, there were no statistically significant differences, that is, 0.5 (IQR 0–2) versus 1 (IQR 0–2), P = 0.908 and 1 (IQR 0–2) versus 0.5 (IQR 0–2), P = 0.929, respectively. Lower morphine requirements were recorded in the first 18 and 24 postoperative hours, that is, 0 (IQR 0–0) versus 1 (IQR 0–2.75) mg, P = 0.028 and 0 (IQR 0–2) versus 1.5 (IQR 0–3) mg, P = 0.012, respectively. Start to sitting and ambulation occurred earlier in the OFA group (P = 0.030 and P = 0.002, respectively). Linear regression showed that ambulation was independently associated with the analgesic technique (P = 0.034). Only one patient had postoperative nausea and vomiting (PONV) and belonged to the OBA group. There was no difference in total complications or the length of stay.

Conclusion:
In this study, OFA strategy was found to be safe, feasible, and provided adequate analgesia, minimizing the use of postoperative opioids, and was independently associated with earlier ambulation.
Safety of perioperative intravenous lidocaine in liver surgery – A pilot study
Authors: Grassin Pierre , Descamps Richard , Bourgine Joanna , Lubrano Jean , Fiant Anne-Lise , Lelong-Boulouard Véronique , Hanouz Jean-Luc 
Published: April 2024

Abstract

Background and Aims:
Perioperative lidocaine infusion has many interesting properties such as analgesic effects in the context of enhanced recovery after surgery. However, its use is limited in liver surgery due to its hepatic metabolism.

Material and Methods:
This prospective, monocentric study was conducted from 2020 to 2021. Patients undergoing liver surgery were included. They received a lidocaine infusion protocol until the beginning of hepatic transection (bolus dose of 1.5 mg kg−1, then a continuous infusion of 2 mg kg−1 h-1). Plasma concentrations of lidocaine were measured four times during and after lidocaine infusion.

Results:
Twenty subjects who underwent liver resection were analyzed. There was 35% of preexisting liver disease before tumor diagnosis, and 75% of liver resection was defined as “major hepatectomy.” Plasmatic levels of lidocaine were in the therapeutic range. No blood sample showed a concentration above the toxicity threshold: 1.6 (1.3–2.1) μg ml−1 one hour after the start of infusion, 2.5 (1.7–2.8) μg ml−1 at the end of hepatic transection, 1.7 (1.3–2.0) μg ml−1 one hour after the end of infusion, and 1.2 (0.8–1.4) μg ml−1 at the end of surgery. Comparative analysis between the presence of a preexisting liver disease or not and the association of intraoperative vascular clamping or not did not show significant difference concerning lidocaine blood levels.

Conclusion:
Perioperative lidocaine infusion seems safe in the field of liver surgery. Nevertheless, additional prospective studies need to assess the clinical usefulness in terms of analgesia and antitumoral effects.