bluuebunny/crossref_metadata_2025_split huggingface dataset:
Leiomyosarcoma of the skin: A case report
Authors: Aranha Gerard V. , Molnar Zelma V. , Reyes Cesar V. , Skladzien Gregory , Valadka Virginia T. 
Published: February 2007

AbstractA middle‐aged man presented with an ulcerated nodule of the right posterior thigh that was histologically evaluated as leiomyosarcoma of the skin. A wide excision of the tumor was followed by split‐thickness skin grafting. Leiomyosarcomas of the skin and subcutaneous tissue are rare tumors, usually occurring in the proximal lower extremities. The treatment of choice is a wide local excision with a 3‐ to 5‐cm margin including the subcutaneous tissue and fascia. The defect is covered by a split‐thickness skin graft.
Excision of solitary brain metastases: Effect on survival
Authors: Abdel‐Dayem Hussein M. , El‐Dayem Ayda M. 
Published: February 2007

AbstractRetrospective analysis of 88 patients treated for brain metastases at Veterans Administration and Erie County Medical Centers, Buffalo, New York, between January 1975 and August 1980 is presented. Patients were followed until January 1981. They were classified into three groups:Group I—15 patients with solitary brain metastases treated by surgical excision followed by radiotherapy (SBM‐S).Group II—32 patients with solitary brain metastases treated by radiotherapy alone (SBM‐RT).Group III—41 patients with multiple brain metastases treated by radiotherapy (MBM‐RT).The average survival was 216 days for the first group versus 80 and 106 days for the second and third groups, respectively. Three patients in the first group were still living at five, eighteen, and twenty‐one months versus one patient each in the second and third group at five months. When brain metastases appeared either at time of presentation or within two months from the diagnosis of the primary disease, excision of solitary brain metastases did not prolong survival. Survival periods were 114, 53, and 81 days for Group I, II, and III, respectively. When brain metastasis appeared after a minimum of two months from the treatment of the primary lesion, excision of solitary brain metastasis did prolong patient survivals for 286 days versus 128 and 94 days for Groups I, II, and III, respectively. When the primary site of origin was inoperable lung cancer or unknown primary cancer no difference in survival between the three groups, survival was 80, 50, and 70 days for Groups I, II, and III, respectively. Percentage survival at 2, 6, and 12 months was 67%, 53%, and 27% in the first group versus 32%, 16%, and 3% for the second group and 41%, 15%, and 5% for the third group. We conclude that excision of solitary brain metastasis might prolong survival in selected patients.
Chemotherapy and pattern of metastases in breast cancer patients
Authors: Amer Magid H. 
Published: February 2007

AbstractA retrospective analysis of all breast cancer patients who died of their disease at Harper Grace Hospital during 1962 to 1976, was conducted to determine the pattern of metastases and its relation to chemotherapy. The autopsy incidence of distant metastases, to all organ sites, was noted to be higher among patients who previously received cytotoxic therapy, compared with those who did not. Such incidence was unrelated to differences in patients' age, menopausal status, and disease‐free interval. It is postulated that chemotherapy contributes to the wider metastases, especially to the central nervous system and meninges, in a breast cancer patient. This is possibly due to a longer survival of patients treated.
Epidemiologic and prognostic factors for lung cancer in a county hospital
Authors: Richard Heath F. , Shalaby Omar F. O. , Abdel‐Dayem Hussein M. 
Published: February 2007

AbstractThis is a study of 269 patients with lung cancer at the Erie County Medical Center who were admitted between 1973 and 1978. They were analyzed for sex, race, age, history of smoking, occupation, tumor cell type, cytology, incidence of metastases, changes in liver function, mode of treatment, and survival. The incidence of cancer was highest in white males. Only 1.5% of patients were under age 40. Smoking was a predisposing factor. Not enough information was available to determine the relationship of occupation to lung cancer. Squamous cell carcinoma was the most common (53.9%), followed by adenocarcinoma (16.0%) and small‐cell carcinoma (12.6%). Sputum cytology was 28.3% sensitive, and bronchial washings were 52.2% sensitive. A greater incidence of bone metastases from a small‐cell primary (50%) was found than is reported in the literature. Changes in SGOT and/or SGPT liver enzymes correlated significantly with liver metastases, but not with tumor cell type. Changes in alkaline phosphatase correlated well with bone metastases. Radiation was the most commonly used mode of therapy. The best survival was achieved in patients treated by surgery (22.6 months), followed by surgery and radiation (16.2 months); those treated by radiation alone had a mean survival time of 8.7 months. Untreated patients had a mean survival time of 2.4 months. Treated patients with adenocarcinomas had the longest survival (18.5 months), compared to 13.0 months for those with squamous cell carcinomas and 8.4 months for those with small‐cell carcinomas. Only three patients survived 5 years, all of whom were treated surgically for adenocarcinoma. No patients with tumors of other cell types survived 5 years. The 5‐year survival rates are 2.1% (3 of 141) for all histologic types of lung cancer and 12.5% (3 of 24) for adenocarcinoma.
Prognostic value of the estrogen receptor level in pathologic stage I and II adenocarcinoma of the breast
Authors: Shapiro C. M. , Schifeling D. , Bitran J. D. , Desser R. K. , Rochman H. , Michel A. , Shapiro R. , Evans R. , Kozloff M. F. , Recant W. , Billings A. A. 
Published: February 2007

AbstractThe relationship between estrogen receptor levels and recurrence of breast cancer was examined in 302 patients with adenocarcinoma of the breast, pathologic stage (PS) I and II. All 117 patients with PS II adenocarcinoma of the breast received adjunctive chemotherapy. In this series, there was no association between the estrogen receptor level and recurrence in either the 185 patients with PS I adenocarcinoma of the breast or the 117 patients with PS II adenocarcinoma of the breast. The most important prognostic variable was the presence or absence of axillary metastases.
Oat cell carcinoma of the esophagus
Authors: Sarma Deba P. 
Published: February 2007

AbstractAn oat cell carcinoma occurring in the esophagus of a 59‐year‐old man is described. A review of another 22 cases of such a tumor from the English literature is made. These tumors may have three histologic patterns: pure oat cell carcinoma, oat cell carcinoma with squamous cell carcinoma, and oat cell carcinoma with adenocarcinoma. They appear to arise from enterochromaffin cells; the neoplastic cells show argyrophilia and neurosecretory‐type granules on electron microscopy. Resection has been the principal mode of therapy. Overall survival for these patients is about 6 months, with most patients dying of extensive metastatic disease.
Tissue reaction to prosthetic obturator materials
Authors: Kent Keith , Beecroft Wayne A. , Roa Uma 
Published: February 2007

AbstractTwo materials are currently used for construction of obturators to restore function when major maxillary defects are present: poly(methyl methacrylate) and poly(dimethyl siloxane). The advantages and disadvantages of the materials are examined and the physiologic response of the involved tissues is studied. Palatectomies were performed on primates and poly‐(methyl methacrylate) and poly(dimethyl siloxane) obturators were placed contacting antral and nasal mucosa. Serial biopsies and clinical evaluations revealed comparable histologic responses to both materials. Poly(dimethyl siloxane) exhibited a more favorable clinical tissue response than poly(methyl methacrylate).
Biochemical evaluation of patients with breast cancer
Authors: Lee YEU‐Tsu N.(Margaret) , Haymond Herman R. , Feder Bernard 
Published: February 2007

AbstractPeripheral blood specimens were obtained from 50 patients with various stages of breast cancer (I‐II = 7, III = 6, IV = 24, treated and NED = 13), and 20 biochemical tests were performed. There are significant differences of hemoglobin, LDH, SGPT, serum protein, albumin, and alpha globulin values between patients with early (I, II, NED) and late (III, IV) lesions. Among patients with stage IV diseases, those patients with bony metastases had significantly higher values of alkaline phosphatase, alpha‐1 globulin, IgA, and C‐reactive protein than those with nonosseous lesions. Neither CEA nor pregnancy‐associated alpha‐2 glycoprotein showed any correlation with different stages or sites of breast cancer in these small series of patients.
Squamous cell carcinoma with sarcomatoid stroma
Authors: Deshotels Seldon J. , Sarma Deba , Fazio Frank , Rodriguez Fred 
Published: February 2007

AbstractTwo cases of squamous cell carcinoma with sarcomatoid stroma are presented. One tumor was located in the soft palate that metastasized to a neck lymph node; the epithelial and the spindle cell component of the tumor at the primary as well as at the metastatic site showed ultrastructural features of squamous cell carcinoma. The other case, a laryngeal tumor with spindle cell stroma, was shown by ultrastructural studies to be composed of proliferating fibro‐blasts. The diagnostic problems and the controversies regarding classification and behavior of these rare tumors of upper respiratory tract and upper gastrointestinal tract are discussed.
Hemostasis in experimental pulmonary injury
Authors: Derisi D. , Cohen H. , Takita H. , Petrelli N. J. , Sharma S. D. , Subramanian S. , Williams P. , Ambrus J. L. 
Published: February 2007

AbstractFibrin Seal (consisting of fibrinogen, cold insoluble globulin, factor XIII, antiplasmin, platelet growth factor, thrombin, and calcium chloride), cryoprecipitate, at Avitene were applied to areas of pulmonary wedge resections in dogs and cynomologus monkeys in an attempt to stop bleeding and air leakage. In the control groups, hemorrhage persisted. Comparing the three hemostatic agents used, Avitene was the least effective followed by cryoprecipitate. Fibrin Seal was most effective. In all cases, it eliminated both air leakage and bleeding.
α‐fetoprotein and carcinoembryonic antigen in pancreatobiliary disease with and without jaundice
Authors: Satake Katsusuke , Cho Keishoku , Umeyama Kaoru 
Published: February 2007

AbstractA comparative study of α‐fetoprotein (AFP) and carcinoembryonic antigen (CEA) in serum was made by radioimmunoassay in 66 patients with pancreatobiliary disease with and without obstructive jaundice, biliary concentrations of these proteins were assayed in 12 patients with benign and 7 patients with malignant disease. There was no statistical difference in serum AFP between these two groups but there was a difference in serum CEA. Although CEA and AFP in bile in both groups were higher than in serum there was no statistical difference in serum CEA and AFP in patients with and without obstructive jaundice in either benign or malignant disease. In benign disease, patients with inflammation had higher serum CEA than normal. Although there was no statistical difference in serum CEA in patients with and without liver metastases, the serum CEA in liver metastases was significantly higher than in benign disease.We concluded that AFP is unlikely to be important in the assessment or management of patients with cancers other than those derived from the liver or yolk sac, and that the elevation of serum CEA in patients with malignant pancreatobiliary disease either with or without obstructive jaundice occurs mainly in the presence of widespread malignancy, especially in liver metastases.
Probiotics: Nonantigenic tissue fractions in cancer control
Authors: Nutini Leo G. , Sperti Georce S. , Fardon John C. , Duarte Alehandro G. , Freidel John F. 
Published: February 2007

AbstractThe effects of probiotics, nonantigenic fractions of normal and malignant cells on tumors, and of similar fractions of normal cells on bacteria and viruses are discussed. The effects are considered in relation to tumor growth and development. In a control group of mice given subcutaneous inoculations only of viable dbrB tumor cells in DBA/1 mice, 100% developed tumors. In a group receiving subcutaneous and intravenous injections of tumor cells and given the tumor fractions, 20% developed lung tumors and 53% developed subcutaneous tumors. In an experiment in which mice received only intravenous injections of viable tumor cells and the tumor fractions, 100% of the controls died with no deaths occurring in the treated group. It is concluded that nonantigenic cellular fractions (probiotics) effective in inducing resistance to some bacterial and viral diseases are effective in inducing resistance to tumors in an inbred strain of mice.
Effect of operation on peripheral lymphocyte counts and production of adenosine triphosphate (ATP) in cancer patients
Authors: Mukherjee Manjari , Sahasrabuddhe M. B. 
Published: February 2007

AbstractLymphocyte bioenergetics in cancer patients undergoing surgery is largely unexplored. The effect of surgery on total lymphocyte counts and adenosine triphosphate (ATP) production is reported. Lymphocyte ATP was assayed by the coupled enzymatic method using hexokinase and glucose 6‐phosphate dehydrogenase and lymphocyte counts were calculated from total leukocyte counts and differential counts.Lymphocyte ATP assay and counts were carried out in 13 patients pre‐ and postoperatively, and lymphocyte counts were scored in six more patients similarly. In 69% of the patients lymphocyte ATP production was depressed postoperatively, and this condition appeared to be associated with cancer spread and immunosuppressive tumors. Postoperative increase in lymphocyte ATP was observed following hysterectomy, colostomy, and also after blood transfusion. The significance of the findings are discussed. Changes in postoperative lymphocyte counts correlated with lymphocyte ATP in 62% of the cases.
Esophageal granular cell tumors report of two multicentric cases with observations on their natural histories
Authors: Cone John B. , Wetzel William J. 
Published: February 2007

AbstractTwo cases of multicentric esophageal granular cell tumors are presented. Treatment was by biopsy only and follow‐up for several years revealed persistent granular cell tumor but no aggressive behavior. A review of the literature is carried out to define the natural history and optimal therapy for these tumors.
Effect of altered thyroid status on lysosomal enzymes and thymidylate synthetase activity in tumors and livers of host animals
Authors: Al‐Jurf Adel S. , Suleiman Suleiman A. , Erenberg Allen P. 
Published: February 2007

AbstractThe purpose of this study was to determine whether or not alternations in tumor growth induced by changes in thyroid status were mediated through changes in key enzymes, whose activity is known to be influenced by thyroid hormones. The activities of three lysosomal enzymes (cathepsin B1, cathepsin D, and acid phosphatase) and thymidylate synthetase were measured in implanted mammary tumors as well as in the livers of host animals that were either euthyroid, hypothyroid, or hyperthyroid. Hypothyroidism produced no significant change in enzyme activity in the tumors. Hyperthyroidism, on the other hand, did cause a significant increase in the activity of all lysosomal enzymes in the tumors, but did not affect thymidylate synthetase levels. In the livers of the host animals, hypothyroidism produced a significant decrease in cathepsin B1 and a significant increase in acid phosphatase but did not change cathepsin D or thymidylate synthetase levels. Hyperthyroidism produced‐a significant increase in all enzymes measured in the livers of the host animals. The significant decrease in tumor weight with hypothyroidism did not correlate with the insignificant changes in the enzymes tested. Similarly, there was no correlation between the significant increase in the enzymes levels found with hyperthyroidism and the insignificant change in tumor weight.
Carcinoid and other tumors metastatic to the breast
Authors: Kashlan R. B. , Powell R. W. , Nolting S. F. 
Published: February 2007

AbstractCarcinoid tumor metastatic to the breast is extremely unusual; only six cases have been reported in the literature to date. Because of the rarity of these tumors primary or metastatic in the breast, and because tumors in general seldom metastasize to the breast, a review of primary carcinoid of the breast and tumors metastatic to the breast is included.
Therapeutic considerations in the management of melanoma
Authors: Kaiser C. William , Ostfeld David 
Published: February 2007

AbstractThe utilization of Breslow‐Clark microstaging has proved helpful in deciding whether or not to perform elective regional node dissection for patients with melanoma. The marked biologic diversity of this disease, however, mandates a strict therapeutic policy of individualization with respect to prognostic variables and special clinical presentation. Specifically, melanomas associated with ulcerations, truncal location, and regional node involvement appear to be more aggressive. Lesions with cutaneous penetration more than 1.5 mm in depth, and showing blood and lymphatic vessel invasion are more often associated with regional node involvement and worse prognosis. The association of any of these adverse prognostic signs with an intermediate thickness lesion (0.76–1.5 mm) may justify elective node dissection. Head and neck, mucosal, and subungual melanomas are all associated with poor prognosis due to rapid growth and early dissemination. The role of elective node dissection in these patients is unclear.
Enterovesical fistula complicating mediterranean lymphoma
Authors: Al‐Janabi Talal , Al‐Saleem Tahseen 
Published: February 2007

AbstractA young Iraqi woman was treated for pathologically documented alpha heavy chain negative Mediterranean lymphoma (MTL). Fourteen months later, she developed entero‐vesical fistula. On reexploration, an extensive abdominal lymphoma was discovered. Pathologically, the neoplastic cells were true histiocytic rather than lymphoplasmacytic.
Effect of perorally administered BCG on recurrent breast cancer
Authors: Kimura Morihiko 
Published: February 2007

AbstractTwenty‐eight patients with recurrent breast carcinoma were examined. Of them, 19 were evaluable for an oral route of BCG administration. Seven (37%) have had partial response (6 bone; 1 supraclavicular lymphonodus), 8 (42%) have shown no change, and 4 (21%) have shown failure.No remarkable side effects were observed by this administration.With regard to immunoresponse by oral administration of BCG, all tendencies such as increase of skin reactions, T‐cells percent, PHA response of lymphocytes, and decrease of IgG FcR + T‐cells useful for estimating a good prognosis.These data suggest that peroral route of BCG may produce some beneficial effects for bone metastatic lesions of recurrent breast cancer.
Self‐retaining ureteral stent catheters in the management of urologic complications of gynecologic malignancies
Authors: Yoonessi Mahmood , Sanchez Frank 
Published: February 2007

AbstractFifteen patients with ureteral obstruction secondary to advanced and/or recurrent gynecologic malignancies underwent endoscopic (3) or surgical transvesical (12) insertion of Gibbons (12) or Double “J” (3) stent catheters. Renal function improvement was noted in all but one patient who had renal parenchymal disease. No complication attributable to the insertion procedure was recorded. This approach to the treatment of ureteral occlusion in patients with gynecologic cancer is discussed and recommended.
Erythropoietin‐dependent erythrocytosis associated with hepatic angiosarcoma
Authors: Rothmann Susan A. , Savage Richard A. , Paul Philip 
Published: February 2007

AbstractErythropoietin (Ep)‐dependent erythrocytosis was discovered in a 77‐year old man with angiosarcoma involving the liver and spleen. At autopsy, tissue from tumorous and normal sections of liver was obtained and extracts prepared for Ep assay in exhypoxic polycythemic mice. Neither tumor nor normal extracts had Ep activity; however, when the extracts were incubated with normal plasma prior to assay, significant amounts of Ep were generated. The normal liver tissue had three times the activity of the tumorous portion, 0.21 U/ml. These results suggest that the tissue contained an Ep activator, probably erythrogenin. It is proposed that the greater amount of erythrogenin activity in the normal tissue may reflect an attempt at liver regeneration following damage by an invading tumor, as regenerating liver has been identified as a stimulus for extrarenal Ep and erythrogenin production.
Carcinoembryonic antigen as a monitor of recurrent breast cancer
Authors: Lee Yeu‐Tsu N.(Margaret) 
Published: February 2007

AbstractCarcinoembryonic antigen (CEA) test was performed at the time of diagnosis in 136 patients with early operable breast carcinoma (stage I = 65, stage II = 71). Only 4% had CEA levels greater than 5 ng/ml. Patients with axillary metastasis (stage II) had higher incidence of abnormal CEAs than those with disease localized to the breast (stage I). Follow‐up CEA tests were performed on 243 patients after mastectomy. In this group, 50 patients developed recurrent disease and 48% had elevated CEA levels. Patients with chest‐wall recurrences rarely had abnormal CEAs, while those with visceral metastasis had higher levels. Among the 193 patients known to be without recurrence, 10% also had elevated CEAs. Excluding inflammatory, hepatic, and renal diseases, the most common medical conditions which could explain such false elevations are diabetes, hypertension, and organic heart disease.
Gastric malignancy: Ten year experience at a community teaching hospital
Authors: Ruggiero Robert P. , Fischer Sharon 
Published: February 2007

AbstractA ten‐year review of gastric malignancy was undertaken and several factors examined. The degree of organ involvement played a significant role in determination of survival. Surgical resection, either palliative or curative, was associated with a more favorable short‐term survival and bypass alone appeared to add nothing to patient survival time. The general lack of symptoms in early gastric cancer appears to be a major determinant of the advanced state of malignancy in these patients. Early screening may represent a partial solution to this dilemma.
Morphological studies of peripheral monocytes during in vitro maturation by scanning electron microscopy
Authors: Krishnan Engikolai C. , Menon Cheruvillil D. , Krishnan Leela , Jewell William R. 
Published: February 2007

AbstractHuman peripheral monocytes were cultured in autologous serum over a period of 14 days. Morphological changes were observed in both light and scanning electron microscopy. Nonspecific esterase, Fc receptor, and phagocytic activites were studied using antibody‐coated sheep erythrocytes. Though the spreading of cytoplasm was observable in a light microscope, scanning electron microscopic pictures revealed several interesting changes during the culture period. The number of filopodia and microvilli increased as the duration in culture increased. At the end of 7 days, almost pure monocytes remained in culture. These cells were characteristically 98–100% nonspecific‐esterase positive, Fc‐receptor positive, and highly phagocytic. This technique may be of value in understanding changes due to various specific and nonspecific immune stimulators.