bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multi-omics and immunogenomics analysis revealed PFKFB3 as a targetable hallmark and mediates sunitinib resistance in papillary renal cell carcinoma: in silico study with laboratory verification
Authors: Lu Zhongwen , Pan Yongsheng , Wang Songbo , Wu Jiajin , Miao Chenkui , Wang Zengjun 
Published: April 2024

AbstractGlycolysis-related metabolic reprogramming is a central hallmark of human cancers, especially in renal cell carcinoma. However, the regulatory function of glycolytic signature in papillary RCC has not been well elucidated. In the present study, the glycolysis-immune predictive signature was constructed and validated using WGCNA, glycolysis-immune clustering analysis. PPI network of DEGs was constructed and visualized. Functional enrichments and patients’ overall survival were analyzed. QRT-PCR experiments were performed to detect hub genes’ expression and distribution, siRNA technology was used to silence targeted genes; cell proliferation and migration assays were applied to evaluate the biological function. Glucose concentration, lactate secretion, and ATP production were measured. Glycolysis-Immune Related Prognostic Index (GIRPI) was constructed and combined analyzed with single-cell RNA-seq. High-GIRPI signature predicted significantly poorer outcomes and relevant clinical features of pRCC patients. Moreover, GIRPI also participated in several pathways, which affected tumor immune microenvironment and provided potential therapeutic strategy. As a key glycolysis regulator, PFKFB3 could promote renal cancer cell proliferation and migration in vitro. Blocking of PFKFB3 by selective inhibitor PFK-015 or glycolytic inhibitor 2-DG significantly restrained renal cancer cells’ neoplastic potential. PFK-015 and sunitinib could synergistically inhibit pRCC cells proliferation. Glycolysis-Immune Risk Signature is closely associated with pRCC prognosis, progression, immune infiltration, and therapeutic response. PFKFB3 may serve as a pivotal glycolysis regulator and mediates Sunitinib resistance in pRCC patients.
The role of the brain renin-angiotensin system in Parkinson´s disease
Authors: Labandeira-Garcia Jose Luis , Labandeira Carmen M. , Guerra Maria J. , Rodriguez-Perez Ana I. 
Published: April 2024

AbstractThe renin-angiotensin system (RAS) was classically considered a circulating hormonal system that regulates blood pressure. However, different tissues and organs, including the brain, have a local paracrine RAS. Mutual regulation between the dopaminergic system and RAS has been observed in several tissues. Dysregulation of these interactions leads to renal and cardiovascular diseases, as well as progression of dopaminergic neuron degeneration in a major brain center of dopamine/angiotensin interaction such as the nigrostriatal system. A decrease in the dopaminergic function induces upregulation of the angiotensin type-1 (AT1) receptor activity, leading to recovery of dopamine levels. However, AT1 receptor overactivity in dopaminergic neurons and microglial cells upregulates the cellular NADPH-oxidase-superoxide axis and Ca2+ release, which mediate several key events in oxidative stress, neuroinflammation, and α-synuclein aggregation, involved in Parkinson's disease (PD) pathogenesis. An intraneuronal antioxidative/anti-inflammatory RAS counteracts the effects of the pro-oxidative AT1 receptor overactivity. Consistent with this, an imbalance in RAS activity towards the pro-oxidative/pro-inflammatory AT1 receptor axis has been observed in the substantia nigra and striatum of several animal models of high vulnerability to dopaminergic degeneration. Interestingly, autoantibodies against angiotensin-converting enzyme 2 and AT1 receptors are increased in PD models and PD patients and contribute to blood–brain barrier (BBB) dysregulation and nigrostriatal pro-inflammatory RAS upregulation. Therapeutic strategies addressed to the modulation of brain RAS, by AT1 receptor blockers (ARBs) and/or activation of the antioxidative axis (AT2, Mas receptors), may be neuroprotective for individuals with a high risk of developing PD or in prodromal stages of PD to reduce progression of the disease.
Impact of the second wave of COVID-19 pandemic on food security among Ho indigenous community of Jharkhand, India
Authors: Ghosh-Jerath Suparna , Dhasmana Ayushi , Nair Swati C. , Kapoor Ridhima 
Published: April 2024

AbstractBackgroundFood insecurity and hunger are global concerns further exacerbated by the unprecedented COVID-19 pandemic. There is a need to understand the depth of this impact, especially among smallholder farmers, and recognize specific coping strategies that offered resilience to inform preparedness in future. The present cross-sectional study assessed the impact of the second wave of COVID-19 pandemic on different dimensions of food security among smallholder farmers of Ho indigenous community of Jharkhand, India. It also explored potential resilient attributes of their food systems.ResultsMost of the respondents (67.2%) reported reduced food consumption at the household (HH) level. Majority faced difficulty in accessing food from different food sources; however, easier access to government food security programmes was highlighted. Around 40% reported change in their ability to purchase farming inputs. Market vendors reported disruptions in food procurement owing to travel restrictions; however, no change was reported for home-produced foods in agricultural lands/kitchen gardens. Prices of indigenous foods produced locally decreased/remained same; however, for cereals, pulses, and other HH staples, prices increased during second wave. Difficulty in accessing wild food environment (OR: 1.7, CI 0.40, 7.75), change in food prices (OR: 19.9, CI 5.25, 76.02), decrease in HH income (OR: 9.2, CI 2.99, 28.60) were found to be significantly associated with reduction in HH food consumption (p < 0.01). The coping strategies adopted by the community included sale of cultivated and wild produce in local weekly markets to ensure additional income.ConclusionsThe findings highlight the need to reinforce the traditional ecological knowledge of the Ho community and focus on practices around their food systems, engrained into their socio-cultural ecosystems that may offer resilience against future stresses. In addition, the need of systemic support to ensure the social and economic well-being of the community needs to be prioritized.
Public perceptions of courts and cooperation with police
Authors: Simpson Rylan , Pappas Laceé N. 
Published: April 2024

AbstractThe police depend upon public cooperation to effectively control crime. Understanding factors that impact people’s willingness to cooperate with the police is thus an important area of empirical research. Drawing upon survey data from a sample of adults (N = 364), we employ a series of regression models to explore the relationship between participants’ perceptions of courts and their willingness to cooperate with the police. Our analyses reveal that participants’ perceptions of courts are associated with their willingness to report crime to the police, particularly minor crime, but not their willingness to assist the police if asked. We discuss our results with respect to discretionary crime reporting, the measurement of cooperation with police, and the nature of interventions aimed at enhancing criminal justice perceptions.
War-related stress scale
Authors: Vargová Lenka , Jozefiaková Bibiána , Lačný Martin , Adamkovič Matúš 
Published: April 2024

Abstract
Background
The current war in Ukraine has affected the well-being of people worldwide. In order to understand how difficult the situation is, specific stressors associated with war need to be measured. In response, an inventory of war-related stressors including its short form, has been developed.

Methods
A list of potential war-related stressors was created, and the content validity of each item assessed. The list, along with other validated scales, was administered to a representative sample of the Slovak population (effective N = 1851). Exploratory factor analysis, confirmatory factor analysis, convergent validity analysis and network analysis were carried out to determine the optimal scale (long and short form) focused on war-related stressors.

Results
The full version of the scale consists of 21 items, further divided into three factors: society-related stressors, person-related stressors, and security-related stressors. The short version of the scale comprises nine items loaded onto one factor. These items cover concerns for one’s safety and future, access to necessities, potential worsening of the economic situation, and the risk of conflict escalation, including a nuclear threat. The results of the network analysis indicate that concern about escalation and fear of an economic crisis play a central role.

Conclusions
The scale attempts to encompass a wide spectrum of areas that are affected by war and its potential consequences on individuals who reside outside the conflict zone. Given the complexity of the issue, researchers are invited to modify the scale, tailoring it to specific cultural, geographical, and temporal contexts.
Quantification of the spatial distribution of individual mangrove tree species derived from LiDAR point clouds
Authors: Kasai Katsumi , Yanagisawa Hideaki , Goto Kazuhisa 
Published: April 2024

AbstractMangrove forests have unquestionably high environmental and ecological value. Mangrove trees are believed to have habitat zonation that is controlled mainly by the relative sea level. However, earlier discussions of mangrove habitats have remained limited in terms of their quality and quantity because of a lack of high-resolution spatial information of microtopography and trees. To clarify mangrove habitability over a wide forest area, we compounded mobile laser scanning (MLS) and aerial laser scanning (ALS) LiDAR dataset of the Miyara River mangrove on Ishigaki Island, Okinawa, Japan. The MLS provided sub-canopy data, while the unmanned aerial vehicle ALS data mainly provided a point cloud of the canopy. We corrected point clouds and combined these data. The results indicated that ALS is unable to reconstruct the microtopography of the dense mangrove area well. Moreover, tree species were not identifiable from the ALS data. However, by applying MLS to the mangrove forest, we obtained high-resolution microtopography and tree information inside the forest, although the measurement area was limited to comparison with ALS. By combining ALS and MLS point clouds, 3D point clouds of the forest were well reconstructed. From these point clouds, a high-resolution digital elevation model was created. Subsequently, we segmented trees individually from composite MLS point clouds and identified each tree species. Consequently, the spatial distribution of thousands of mangrove trees was reconstructed at the Miyara River mouth. The spatial distribution of mangrove tree species together with earlier aerial photographs suggests that mangrove species have been segregated in accordance with changes in their elevation and environment over 40 years. Our findings suggest that the distribution of the species changed sensitively along with dynamic variation of the microtopography.
Improvement of epilepsy secondary to acquired immunodeficiency syndrome with intestinal microbiota preparations: a case report
Authors: Lin Chuhui , Zeng Ting , Deng Yuhong 
Published: April 2024

Abstract
Background
Epilepsy secondary to acquired immunodeficiency syndrome (AIDS) can be challenging to manage. The potential interactions between antiretroviral drugs and antiepileptic drugs may result in the failure of both treatments. Therefore, it is crucial to develop more effective strategies to enhance the clinical outcomes of patients.

Case presentation
We report a case of epilepsy secondary to AIDS. After administration of Bacteroides Fragilis 839 (BF839), the secondary generalized tonic-clonic seizures disappeared, the frequency of complex partial seizures decreased by 70%, and the duration of each episode was shortened. Additionally, long-term diarrhea associated with antiretroviral therapy for AIDS resolved, and the syphilis serofast reaction turned negative. No serious adverse reactions were observed during the three-year follow up.

Conclusions
This case report suggests that the specific gut microbiota preparation could possibly improve refractory epilepsy in HIV patients while also potentially alleviating adverse reactions to antiretroviral drugs and concurrent syphilis infection. Our case may provide a new perspective for the treatment of HIV infection/AIDS.
A novel whole-team training programme for adult eating disorder services in England: rationale, development and preliminary evaluation
Authors: Novogrudsky Kat , Gray Tom , Mitchell Emily , Attoe Chris , Kern Nikola , Griffiths Jess , Serpell Lucy , Treasure Janet , Schmidt Ulrike 
Published: April 2024

Aims and method
In response to recommendations for improving the quality and coordination of care delivered by eating disorder services, a whole-team training programme was commissioned by Health Education England in 2020. This paper describes the development and evaluation of the Eating Disorder Services for Adults (EDSA) whole-team training course, delivered to National Health Service adult eating disorder community teams in England. Course participants (n = 561) in the first two EDSA training cohorts (2021 and 2022) were asked to complete questionnaires at intake and after each session, asking about their views on the training.

Results
All course aspects were rated as highly enjoyable, meeting participants’ training needs and fostering reflective practice. Thematic analysis identified themes relating to key innovative features of the course and suggestions for improvements.

Clinical implications
Preliminary evaluation suggests that EDSA is valued by clinicians to enhance their knowledge, skills and ability to improve eating disorder patient care.
An information-theoretic analog of the twin paradox
Authors: Kovačević Mladen , Pinelis Iosif , Kountouris Marios 
Published: April 2024

Abstract
We revisit the familiar scenario involving two parties in relative motion, in which Alice stays at rest while Bob goes on a journey at speed βc along an arbitrary trajectory and reunites with Alice after a certain period of time. It is a well-known consequence of special relativity that the time that passes until they meet again is different for the two parties and is shorter in Bob's frame by a factor of

. We investigate how this asymmetry manifests itself from an information-theoretic viewpoint. Assuming that Alice and Bob transmit signals of equal average power to each other during the whole journey, and that additive white Gaussian noise is present at both sides, we show that the maximum number of bits per second that Alice can transmit reliably to Bob is always higher than the one Bob can transmit to Alice. Equivalently, the energy per bit invested by Alice is lower than that invested by Bob, meaning that the traveler is less efficient from the communication perspective, as conjectured by Jarett and Cover.
The missense mutation C667F in murine β-dystroglycan causes embryonic lethality, myopathy and blood-brain barrier destabilization
Authors: Tan Rui Lois , Sciandra Francesca , Hübner Wolfgang , Bozzi Manuela , Reimann Jens , Schoch Susanne , Brancaccio Andrea , Blaess Sandra 
Published: April 2024

ABSTRACT
Dystroglycan (DG) is an extracellular matrix receptor consisting of an α- and a β-DG subunit encoded by the DAG1 gene. The homozygous mutation (c.2006G&gt;T, p.Cys669Phe) in β-DG causes muscle-eye-brain disease with multicystic leukodystrophy in humans. In a mouse model of this primary dystroglycanopathy, approximately two-thirds of homozygous embryos fail to develop to term. Mutant mice that are born undergo a normal postnatal development but show a late-onset myopathy with partially penetrant histopathological changes and an impaired performance on an activity wheel. Their brains and eyes are structurally normal, but the localization of mutant β-DG is altered in the glial perivascular end-feet, resulting in a perturbed protein composition of the blood-brain and blood-retina barrier. In addition, α- and β-DG protein levels are significantly reduced in muscle and brain of mutant mice. Owing to the partially penetrant developmental phenotype of the C669F β-DG mice, they represent a novel and highly valuable mouse model with which to study the molecular effects of β-DG functional alterations both during embryogenesis and in mature muscle, brain and eye, and to gain insight into the pathogenesis of primary dystroglycanopathies.
Z Isfahanu do Warszawy
Authors: Skowron Ryszard 
Published: April 2024

FROM ISFAHAN TO WARSAW: POSTHUMOUS INVENTORIES OF SALOMON SYRI (ZGÓRSKI), ENVOY OF JAN III SOBIESKI TO PERSIA
The embassy of Salomon Syri (Zgórski), an Armenian in the service of Polish King Jan III Sobieski, to Persian Shah Suleiman I, undertaken in 1688-1690, was related to efforts to include Persia in the anti-Ottoman alliance. It was also connected with the Jesuit mission in the 1680s, aiming to reach China via Siberia. However, Syri was killed in Isfahan during the mission and was buried in the Jesuit church there. After the diplomat’s death, Poles residing in the capital of Persia compiled an inventory of his belongings, packed them into several crates, and sent them to Poland through Moscow. The University of Warsaw Library holds four handwritten inventories of Syri’s property, prepared in Moscow by the Polish resident Jerzy Dominik Dowmont. He sent to his king the belongings of the envoy in several parts. The inventories of Syri’s property, published in the article, constitute important and unique sources for the history of both Polish diplomacy and Polish material culture.
Ազգային հիշողությունը՝ ուծացած հայերի սերունդների մեջ
Authors: Bakczynian Arcwi 
Published: April 2024

NATIONAL MEMORY, ASSIMILATED IN GENERATIONS OF ARMENIANS
Assimilation and national acculturation are inevitable phenomena to which every ethnic community separated from its native environment is vulnerable. The ways and degrees of its manifestation vary, but the direction is the same: moving away from the native national profile and assimilating characteristics typical of the nation and culture of the country of residence. Cases of assimilation also occur to a lesser extent when a nation becomes a minority in its own homeland or when its native environment is absorbed by an empire. The article analyzes such situations among Armenians, specifically in Armenian diasporas. It concludes that the pace of assimilative changes depends on various factors, including maintaining formal points of contact with Armenia (citizenship, organizational ties, owning a house in Armenia, etc.), and a measured and consistent policy of the Armenian state towards the diaspora.
Computing Optimality Certificates for Convex Mixed-Integer Nonlinear Problems
Authors: Halbig Katrin , Hümbs Lukas , Rösel Florian , Schewe Lars , Weninger Dieter 
Published: April 2024

Every optimization problem has a corresponding verification problem that checks whether a given optimal solution is in fact optimal. In the literature, there are a lot of such ways to verify optimality for a given solution, for example, the branch-and-bound tree. To simplify this task, optimality certificates were introduced for convex mixed-integer nonlinear programs, and it was shown that the sizes of the certificates are bounded in terms of the number of integer variables. We introduce an algorithm to compute the certificates and conduct computational experiments. Through the experiments, we show that the optimality certificates can be surprisingly small. History: Accepted by Andrea Lodi, Area Editor for Design & Analysis of Algorithms—Discrete. Funding: This work was supported by the Deutsche Forschungsgemeinschaft [CRC 154 Subproject A05, CRC 154 Subproject B07, and SFB Transregio 154], the Bundesministerium für Wirtschaft und Energie. Supplemental Material: The software that supports the findings of this study is available within the paper and its Supplemental Information ( https://pubsonline.informs.org/doi/suppl/10.1287/ijoc.2022.0099 ) as well as from the IJOC GitHub software repository ( https://github.com/INFORMSJoC/2022.0099 ). The complete IJOC Software and Data Repository is available at https://informsjoc.github.io/ .
What Makes HFTs Tick? Tick Size Changes and Information Advantage in a Market with Fast and Slow Traders
Authors: Chaboud Alain P. , Dao Avery , Vega Clara , Zikes Filip 
Published: April 2024

We study the impact of two changes in the minimum tick size, a reduction and a subsequent increase, on the trading behavior of fast and slow traders in the spot foreign exchange market. We find that the most notable impact of the tick size reduction is a substantial increase in the liquidity demand of high-frequency traders (HFTs) and not the decrease in their liquidity provision discussed by prior literature. We show that this change in behavior is linked to the higher frequency of price signals that arises with the smaller tick size and to the ability of fast traders to profit from it, often at the detriment of slower traders. Following the tick size decrease and the increase in liquidity demand by HFTs in the spot market, the role of the spot market in price discovery drops relative to that of the futures market. We discuss these findings in the context of the impact of HFTs on the information content of financial markets. This paper was accepted by Agostino Capponi, finance. Supplemental Material: The data files are available at https://doi.org/10.1287/mnsc.2022.02935 .
Remote Work and Job Applicant Diversity: Evidence from Technology Startups
Authors: Hsu David H. , Tambe Prasanna B. 
Published: April 2024

A significant element of managerial post-COVID job design regards remote work. In an era of renewed recognition of diversity, employers may wonder how diverse (gender and race) and experienced job applicants respond to remote job listings, especially for high-skilled technical and managerial positions. Prior work has shown that while remote work allows employee flexibility, it may limit career promotion prospects, so the net effect of designating a job as remote-eligible is not clear from an applicant interest standpoint, particularly when recruiting females and underrepresented minorities (URM). We analyze job applicant data from a leading startup job platform that spans long windows before and after the COVID-19 pandemic-induced shutdowns of March 2020. To address the empirical challenge that remote job designation may be codetermined with unobserved job and employer characteristics, we leverage a matching approach (and an alternative method which leverages the sudden shutdowns) to estimate how applicant characteristics differ for otherwise similar remote and onsite job postings. We find that offering remote work attracts more experienced and diverse (especially URM) job applicants, with larger effects in less diverse geographic areas. A discrete change in job posting to remote status (holding all else constant) is associated with an approximately 15% increase in applicants who are female, 33% increase in applicants with URM status, and 17% increase in applicant experience. Using the application data, we estimate an average estimated compensating wage differential for remote work that is about 7% of posted salaries in this labor market. This paper was accepted by Olav Sorenson, organizations. Funding: This work was supported by Mack Institute for Innovation Management at the University of Pennsylvania. Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2022.03391 .