bluuebunny/crossref_metadata_2025_split huggingface dataset:
Compulsive buying: A cognitive–behavioural model
Authors: Kellett Stephen , Bolton Jessica V. 
Published: February 2009

AbstractCompulsive buying (CB) has only relatively recently become a topic of interest for researchers and clinicians alike. This hiatus means that (unlike other impulse control disorders) there is currently little theoretical guidance for clinicians attempting to intervene with CB clients and no established model for researchers to evaluate, distil and refine. The current paper summarizes and organizes the main extant identified factors in the CB literature into four distinct phases: (1) antecedents; (2) internal/external triggers; (3) the act of buying; and finally, (4) post‐purchase. The relationships and interactions between the identified phases are then hypothesized, within the proposed cognitive–behavioural model. The model distinguishes the key cognitive, affective and behavioural factors within each phase and identifies how CB can become self‐reinforcing over time. The over‐arching treatment implication is that CB can be re‐conceptualized as chronic and repetitive failure in self‐regulation efforts, and that psychological interventions can accommodate this in attempting to facilitate change. A successful case example is provided of a ‘co‐dependent compulsive buyer’ using the model, with psychometric evaluation of key aspects of CB and mental health at assessment, termination and 6‐month follow‐up. The research and clinical implications of the proposed model are discussed, alongside identified short‐comings and the need for psychological services to respond appropriately to CB clients seeking help. Copyright © 2009 John Wiley & Sons, Ltd.
Electrophilic Activation of Aldehydes “On Water”: A Facile Route to Dipyrromethanes
Authors: Zoli Luca , Cozzi Pier Giorgio 
Published: February 2009

AbstractShaken …︁ and stirred: Dipyrromethane, an important building block in porphyrin chemistry, can be easily accessed by a reaction performed on water in the absence of Lewis acids. Thus, a variety of substituted dipyrromethanes were prepared in moderate to good yields using a range of aldehydes.magnified image
Design and implementation of optimized architecture for computing the 2D‐DWT for JPEG2000 compression
Authors: Souani Chokri , Gazzah Ihsen , Besbes Kamel 
Published: February 2009

AbstractTo obtain an effective and efficient system, a multitude of architectural solutions must be assessed and their performances compared. Design and evaluation of several hardware architectures require enormous time for their development and the evaluation. In this paper, an exploration of possible architectures for the 2D‐discrete wavelet transform (DWT) is accomplished. Particularly, filters used by the standard JPEG2000 are studied: the lossy 9/7 and the lossless 5/3 filters. The designs have been coded with high description level using Handel‐C language and the target hardware is Xilinx FPGA of the Virtex‐4 family. It is known that the technique of in‐place calculation of the 2D‐DWT by lifting scheme allows saving space memory, but the problem is that the computed coefficients are not stored in consecutive addresses, and a system for address decoding becomes necessary. The address decoding must be made at every new decomposition level. We propose then a new simple and efficient technique that allows storing the calculated coefficients in a homogeneous space memory and in consecutive addresses. No additional memory or address decoding is necessary. Finally, the designed system allows a rather high throughput and optimized number of hardware resources. Copyright © 2009 John Wiley & Sons, Ltd.
Aminotroponiminate Zinc Complexes with Different Leaving Groups as Catalysts for the Intramolecular Hydroamination of Alkenes
Authors: Löhnwitz Karolin , Molski Matthias J. , Lühl Anja , Roesky Peter W. , Dochnahl Maximilian , Blechert Siegfried 
Published: February 2009

AbstractThe (aminotroponiminato)phenylzinc complexes {N‐isopropyl‐2‐(isopropylamino)troponiminato}phenylzinc, [{ATI(iPr)2}ZnPh], {N‐isopropyl‐2‐(isopropylamino)‐5‐(phenylsulfanyl)troponiminato}phenylzinc, [{PhS‐ATI(iPr)2}ZnPh], {N‐cyclohexyl‐2‐(cyclohexylamino)troponiminato}phenylzinc, [{ATI(Cy)2}ZnPh] and the corresponding bis(trimethylsilyl)amido compounds [{ATI(iPr)2}ZnN(SiMe3)2], [{PhS‐ATI(iPr)2}ZnN(SiMe3)2], and [{ATI(Cy)2}ZnN(SiMe3)2] were prepared and fully characterized. These compounds were obtained by reaction of the corresponding aminotroponimines with ZnPh2 and [Zn{N(SiMe3)2}2], respectively. The new complexes were compared with the corresponding methylzinc complexes, which were previously reported, to study the influence of the substituents of the zinc atom in the catalytic hydroamination/cyclization reaction. In the presence of equimolar amounts of [PhNMe2H][B(C6F5)4] it was shown that the methyl und phenyl compounds show comparable activities, while those bearing a bis(trimethylsilyl)amido group are significantly slower. Obviously the size of the leaving group and the nature of the formed by‐product have a significant influence on the reaction rate.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Rhodium(I) Complexes of New Ferrocenyl Benzimidazol‐2‐ylidene Ligands: The Importance of the Chelating Effect for Ketone Hydrosilylation Catalysis
Authors: Gülcemal Süleyman , Labande Agnès , Daran Jean‐Claude , Çetinkaya Bekir , Poli Rinaldo 
Published: February 2009

AbstractN‐[(1‐Phosphanylferrocen‐1′‐yl)methyl]‐N′‐[(2,4,6‐trimethylphenyl)methyl]‐5,6‐di‐X‐benzimidazolium tetrafluoroborate salts (X = H, 5a and Me, 5b), precursors of new phosphane‐benzimidazol‐2‐ylidene bifunctional ligands, and related ferrocenyl 5,6‐di‐X‐benzimidazol‐2‐ylidene iodide salts (X = H, 6a and Me, 6b), precursors of monodentate benzimidazol‐2‐ylidene ligands, have been prepared for the first time. Cationic rhodium(I) complexes 7a and 7b and neutral rhodium(I) complexes 8a and 8b have been obtained in good yields and have been fully characterised. Cationic rhodium(I) complexes 10a and 10b were prepared from 8a and 8b, for comparison with complexes 7, but not isolated. All complexes showed good activities for the catalytic hydrosilylation of acetophenone derivatives. The activities are much greater than for related imidazol‐2‐ylidene systems, and the cationic complexes are more active than the neutral complexes; the highest activity is observed for the more soluble complex 7b. The use of bidentate ligands proved to be essential for obtaining good selectivities of the desired alcohol.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Fast derivatization of the non‐protein amino acid ornithine with FITC using an ultrasound probe prior to enantiomeric determination in food supplements by EKC
Authors: Domínguez‐Vega Elena , Martínez‐Girón Ana Belén , García‐Ruiz Carmen , Crego Antonio L. , Marina María Luisa 
Published: February 2009

AbstractAn EKC method for the determination of ornithine (Orn) enantiomers has been developed after a fast pre‐capillary derivatization with FITC. The derivatization step was needed to provide a chemical moiety to the Orn molecule, enabling a sensitive UV detection and the interaction with the CDs used as chiral selectors. To accelerate the derivatization reaction, an ultrasound probe was used. For the development of the chiral method, the influence of different experimental conditions (type and concentration of the chiral selector, temperature, and separation voltage) was investigated. Due to the anionic nature of the analyte (FITC‐Orn), five neutral CDs were employed as chiral selectors. The native γ‐CD showed the highest chiral separation power, observing that a low concentration of this CD (1 mM), using a working temperature of 25°C and a separation voltage of 20 kV, enabled to obtain the highest enantioresolution for Orn and its separation from other amino acids usually present in food supplements. After optimizing the method for the preconditioning of the capillary, the analytical characteristics of the chiral method were established. Linearity, LOD and LOQ, precision, and accuracy were evaluated previously to the determination of Orn enantiomers contained in ten commercial food supplements. No interferences from other amino acids present in these samples were observed.
Development of a non‐aqueous electrophoresis method for the simultaneous determination of tricyclic antidepressants in human serum
Authors: Acedo‐Valenzuela María‐Isabel , Galeano‐Díaz Teresa , Rodríguez Antonio Silva , Martínez Rita Carabias , Álvarez Javier Domínguez 
Published: February 2009

AbstractIn the present work we report a non‐aqueous electrophoresis method (NACE) for the separation and determination of eight tricyclic antidepressants (TCAs) in human serum. Separation is carried out in 1 M acetic acid, 50 mM ammonium acetate and 10 mM SDS in ACN. Standards and samples were prepared in 0.8 M acetic acid in ACN and introduced by electrokinetic injection. The interactions between TCAs and acetate ions were studied and deduced from comparison of both the actual experimental and theoretical mobility. The establishment of calibration curves in the presence or absence of serum matrix, between 20 and 200 ng/mL, together with the determination of most important analytical parameters and a study of robustness were performed. Validation of the CE method was carried out with serum samples spiked with the analytes. The NACE determination method offers better resolution and higher sensitivity than the determination of TCAs in aqueous media.
Large volume stacking using an EOF pump in NACE‐MS
Authors: Kim Jihye , Chun Man‐Seog , Choi Kihwan , Chung Doo Soo 
Published: February 2009

AbstractLarge volume stacking using an EOF pump (LVSEP) is realized for CE with ESI‐MS. In LVSEP of anions, the adverse effects of a long sample matrix plug were overcome by pumping the plug out of the separation capillary to the inlet vial using the EOF under a potential of reverse polarity. Therefore, it was necessary to supply a backup run buffer from the outlet end of the capillary, which was not trivial in most ESI‐MS configurations. We solved this difficulty simply by placing a vial supplying a backup run buffer during the matrix removal and sample stacking process. In addition, methanol was used as the run buffer solvent enabling a bare fused‐silica capillary to meet the requirement of suppressed EOF. This LVSEP CE/ESI‐MS has been successfully applied to six anionic analytes, achieving 400‐fold enrichment in the detection sensitivity by using a conventional sheath liquid CE/ESI‐MS interface without any physical modification.
Improved simultaneous enantioseparation of β‐agonists in CE using β‐CD and ionic liquids
Authors: Huang Lu , Lin Jin‐Ming , Yu Lishuang , Xu Liangjun , Chen Guonan 
Published: February 2009

AbstractIn this study, approaches to improve chiral resolutions in simultaneous enantioseparation of β‐agonists by CE via a CD inclusion complexation modified with ionic liquids (ILs) are described. Different types of ILs, including tetraalkylammonium‐based ILs, alkylimidazolium‐based ILs and alkylpyridinium‐based ILs, were examined and compared for controlling the EOF in order to improve resolutions of β‐agonists enantiomers. In this regard, tetraalkylammonium‐based ILs were more effective because they could be used at much higher concentrations than other types of ILs. N‐octylpyridinium hexafluorophosphate gave poor resolutions of β‐agonists enantiomers. In addition, when different ILs were mixed to use, they would present particular properties of their own. Moreover, the presence of ILs was essential in the chiral separations of (±) salbutamol, (±) cimaterol and (±) formoterol, which were reportedly not enantioseparated by using the buffer electrolytes containing only β‐CD as a chiral selector.
Use of centromeric and telomeric DNA probes in in situ hybridization for differentiation of micronuclei induced by lomefloxacin
Authors: Attia Sabry M. 
Published: February 2009

AbstractClassification of micronuclei induced by lomefloxacin, a difluorinated quinolone bactericidal agent, in mouse bone marrow was performed by fluorescence in situ hybridization using DNA probes for the centromere repeated minor satellite DNA and the telomeric hexamer repeat (5′‐TTAGGG‐3′). Colchicine and mitomycin C were used as a positive control aneugen and clastogen, respectively, and these compounds produced the expected responses. Single doses of 40, 80, 160, or 320 mg/kg lomefloxacin were given via oral intubations and bone marrow was sampled at 24 and 48 hr after treatment. The micronuclei showed significant increases in both sampling times after doses of 320 mg/kg. A statistically significant increase of micronuclei frequency was also detected for 160 mg/kg lomefloxacin at 48 hr aftertreatment. The responses were directly correlated with bone‐marrow cytotoxicity. Following treatment with 160 and 320 mg/kg lomefloxacin, 48.2 and 50.0% of the induced micronuclei, respectively, showed double labeling with centromeric signals and several telomeric signals, indicating that the induced micronuclei were composed of whole chromosomes. Similarly, 51.8 and 50.0% of the induced micronuclei, respectively, were centromere‐negative, demonstrating that lomefloxacin not only induces chromosome loss but also chromosome breakage. The results also showed that chromosomes can be enclosed in a micronucleus before and after centromere separation. Overall, this study provides the first evidence of the potential of lomefloxacin to induce aneugenic effect in mice. However, given the high doses used in this study, the clinical significance of this finding is uncertain. Environ. Mol. Mutagen. 2009. © 2009 Wiley‐Liss, Inc.
MMP‐9 controls Schwann cell proliferation and phenotypic remodeling via IGF‐1 and ErbB receptor‐mediated activation of MEK/ERK pathway
Authors: Chattopadhyay Sharmila , Shubayev Veronica I. 
Published: February 2009

AbstractPhenotypic remodeling of Schwann cells is required to ensure successful regeneration of damaged peripheral axons. After nerve damage, Schwann cells produce an over 100‐fold increase in metalloproteinase‐9 (MMP‐9), and therapy with an MMP inhibitor increases the number of resident (but not infiltrating) cells in injured nerve. Here, we demonstrate that MMP‐9 regulates proliferation and trophic signaling of Schwann cells. Using in vivo BrdU incorporation studies of axotomized sciatic nerves of MMP‐9−/− mice, we found increased Schwann cell mitosis in regenerating (proximal) stump relative to wild‐type mice. Treatment of cultured primary Schwann cells with recombinant MMP‐9 suppressed their growth, mitogenic activity, and produced a dose‐dependent, biphasic, and selective activation of ERK1/2, but not JNK and p38 MAPK. MMP‐9 induced ERK1/2 signaling in both undifferentiated and differentiated (using dbcAMP) Schwann cells. Using inhibitors to MEK and trophic tyrosine kinase receptors, we established that MMP‐9 regulates Ras/Raf/MEK—ERK pathways through IGF‐1, ErbB, and PDGF receptors. We also report on the early changes of MMP‐9 mRNA expression (within 24 h) after axotomy. These studies establish that MMP‐9 controls critical trophic signal transduction pathways and phenotypic remodeling of Schwann cells. © 2009 Wiley‐Liss, Inc.
Aquaporin‐4 orthogonal arrays of particles are the target for neuromyelitis optica autoantibodies
Authors: Nicchia Grazia Paola , Mastrototaro Mauro , Rossi Andrea , Pisani Francesco , Tortorella Carla , Ruggieri Maddalena , Lia Anna , Trojano Maria , Frigeri Antonio , Svelto Maria 
Published: February 2009

AbstractNeuromyelitis optica (NMO) is an inflammatory autoimmune demyelinating disease of the central nervous system (CNS) which in autoantibodies produced by patients with NMO (NMO‐IgG) recognize a glial water channel protein, Aquaporin‐4 (AQP4) expressed as two major isoforms, M1‐ and M23‐AQP4, in which the plasma membrane form orthogonal arrays of particles (OAPs). AQP4‐M23 is the OAP‐forming isoform, whereas AQP4‐M1 alone is unable to form OAPs. The function of AQP4 organization into OAPs in normal physiology is unknown; however, alteration in OAP assemblies is reported for several CNS pathological states. In this study, we demonstrate that in the CNS, NMO‐IgG is able to pull down both M1‐ and M23‐AQP4 but experiments performed using cells selectively transfected with M1‐ or M23‐AQP4 and native tissues show NMO‐IgG epitope to be intrinsic in AQP4 assemblies into OAPs. Other OAP‐forming water‐channel proteins, such as the lens Aquaporin‐0 and the insect Aquaporin‐cic, were not recognized by NMO‐IgG, indicating an epitope characteristic of AQP4‐OAPs. Finally, water transport measurements show that NMO‐IgG treatment does not significantly affect AQP4 function. In conclusion, our results suggest for the first time that OAP assemblies are required for NMO‐IgG to recognize AQP4. © 2009 Wiley‐Liss, Inc.,
Nerve growth factor attenuates proliferation of astrocytes via the p75 neurotrophin receptor
Authors: Cragnolini Andrea B. , Huang Yangyang , Gokina Pradeepa , Friedman Wilma J. 
Published: February 2009

AbstractThe p75 neurotrophin receptor has been implicated in the regulation of multiple cellular functions that differ depending on the cell context. We have observed that p75NTRis strongly induced on astrocytes as well as neurons in the hippocampal CA3 region after seizures; however, the function of this receptor on these glial cells has not been defined. We have employed a primary culture system to investigate the effects of neurotrophins on astrocytes. Treatment of hippocampal astrocytes with nerve growth factor (NGF) caused a reduction in cell number, but did not elicit an apoptotic response, in contrast to hippocampal neurons. Instead, activation of p75NTRby NGF attenuated proliferation induced by mitogens such as EGF or serum. These studies demonstrate the cell type specificity of neurotrophin functions in the brain. © 2009 Wiley‐Liss, Inc.
Prolyl hydroxylase inhibitor dimethyloxalylglycine enhances mesenchymal stem cell survival
Authors: Liu Xian‐Bao , Wang Jian‐An , Ogle Molly E. , Wei Ling 
Published: February 2009

AbstractMesenchymal stem cell (MSC) transplantation is a promising approach in the therapy of ischemic heart or CNS diseases; however, the poor viability of MSCs after transplantation critically limits the efficacy of this new strategy. Prolyl hydroxylase inhibition followed by HIF‐1α up‐regulation participates in the regulation of apoptosis and cell survival, which have been shown in cancer cells and neurons. The role of prolyl hydroxylase inhibition by dimethyloxalylglycine (DMOG) in regulation of cell survival has not been investigated in MSCs. In the present investigation with MSCs, apoptosis and cell death induced by serum deprivation were assessed by caspase‐3 activation and trypan blue staining, respectively. The mitochondrial apoptotic pathway and PI3K/Akt cell survival pathway were evaluated. DMOG significantly attenuated apoptosis and cell death of MSCs, stabilized HIF‐1α and induced downstream glucose transport 1 (Glut‐1) synthesis. DMOG treatment reduced mitochondrial cytochrome c release, nuclear translocation of apoptosis inducing factor (AIF), and promoted Akt phosphorylation. A specific PI3K inhibitor, wortmannin, blocked Akt phosphorylation and abrogated the beneficial effect of DMOG. These data suggest that the DMOG protection of MSCs may provide a novel approach to promote cell survival during cell stress. J. Cell. Biochem. 106: 903–911, 2009. © 2009 Wiley‐Liss, Inc.
Target identification of microRNAs expressed highly in human embryonic stem cells
Authors: Li Steven Shoei‐Lung , Yu Sung‐Liang , Kao Li‐Pin , Tsai Zong Yun , Singh Sher , Chen Bo Zhi , Ho Bing‐Ching , Liu Yung‐Hsien , Yang Pan‐Chyr 
Published: February 2009

AbstractMicroRNAs (miRNAs) are noncoding RNAs of approximately 22 nucleotides in length that negatively regulate the post‐transcriptional expression by translational repression and/or destabilization of protein‐coding mRNAs. The impact of miRNAs on protein output was recently shown that although some targets were repressed without detectable changes in mRNA levels, those translationally repressed by more than a third also displayed detectable mRNA destabilization, and, for the more highly repressed targets, mRNA destabilization usually comprised the major component of repression. Thus, comparative profilings of miRNAs and mRNAs from the same samples of different cell types may identify the putative targets of miRNAs. In this investigation, both miRNA and mRNA profiles from the undifferentiated human embryonic stem cell line hES‐T3 (T3ES), hES‐T3 derived embryoid bodies (T3EB), and hES‐T3 differentiated fibroblast‐like cells (T3DF) were compared, and 58 genes were found to be targets of four hES cell‐specific miRNAs miR‐302d, miR‐372, miR‐200c and/or miR‐367 by inverse expression levels (highly negative correlation) of miRNAs to their target mRNAs. Approximately half of these 58 targets are involved in gene transcription. Three common target genes TRPS1, KLF13 and MBNL2 of three highly expressed miRNAs miR‐302d, miR‐372, and miR‐200c were identified, and the target sites of both miR‐302d and miR‐372 in the 3′UTR of TRPS1, KLF13, and MBNL2 genes were confirmed by the luciferase assay. The highly expressed mRNAs and miRNA target mRNAs involved in KEGG pathways among T3ES, T3EB, and T3DF cells were also compared, and the expression levels of target mRNAs predicted by abundantly expressed miRNAs were found to be three‐ to sixfold lower than those of non‐target mRNAs involved in the same signaling pathways. J. Cell. Biochem. 106: 1020–1030, 2009. © 2009 Wiley‐Liss, Inc.
Trafficking and differentiation of mesenchymal stem cells
Authors: Liu Zhao‐Jun , Zhuge Ying , Velazquez Omaida C. 
Published: February 2009

AbstractMesenchymal stem cells (MSCs) are a heterogeneous population of stem/progenitor cells with pluripotent capacity to differentiate into mesodermal and non‐mesodermal cell lineages, including osteocytes, adipocytes, chondrocytes, myocytes, cardiomyocytes, fibroblasts, myofibroblasts, epithelial cells, and neurons. MSCs reside primarily in the bone marrow, but also exist in other sites such as adipose tissue, peripheral blood, cord blood, liver, and fetal tissues. When stimulated by specific signals, these cells can be released from their niche in the bone marrow into circulation and recruited to the target tissues where they undergo in situ differentiation and contribute to tissue regeneration and homeostasis. Several characteristics of MSCs, such as the potential to differentiate into multiple lineages and the ability to be expanded ex vivo while retaining their original lineage differentiation commitment, make these cells very interesting targets for potential therapeutic use in regenerative medicine and tissue engineering. The feasibility for transplantation of primary or engineered MSCs as cell‐based therapy has been demonstrated. In this review, we summarize the current knowledge on the signals that control trafficking and differentiation of MSCs. J. Cell. Biochem. 106: 984–991, 2009. © 2009 Wiley‐Liss, Inc.