bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes of repeated endoscopic submucosal dissection for superficial Esophageal squamous cell carcinoma on endoscopic resection scar
Authors: Furue Yasuaki , Yoda Yusuke , Hori Keisuke , Nakajo Keiichiro , Kadota Tomohiro , Murano Tatsuro , Shinmura Kensuke , Ikematsu Hiroaki , Yano Tomonori 
Published: March 2024

Summary

Background
Endoscopic submucosal dissection (ESD) can be performed for superficial esophageal cancer. However, performing ESD for superficial esophageal cancer on a previous endoscopic resection scar may be difficult.

Methods
We compared the outcomes between ESD for superficial esophageal cancers on previous endoscopic resection scar (group A) and that for naïve lesions (group B). The study included outcomes of ESD, cumulative incidence of local failure, and predictors of the occurrence of local failure in ESD patients with squamous cell carcinoma (SCC). The outcome variables evaluated were en bloc resection rates, procedure times, adverse events, and overall survival rates.

Results
Overall, 220 lesions were extracted (groups A and B: 23 and 197 lesions, respectively). In groups A and B, the complete resection rates were 60.9 and 92.9% (P &lt; 0.001), and the mean procedure times were 79 and 68 min (P = 0.15), respectively. The perforation rates in groups A and B were 4.3 and 1% (P = 0.28). The 1-year cumulative local failure rates were 22 and 1% (P &lt; 0.001), respectively. In the multivariate Cox proportional hazards analysis, superficial esophageal SCC on a previous endoscopic resection scar was a strong predictor of local failure (hazard ratio = 21.95 [3.99–120.80], P &lt; 0.001). The 3-year overall survival rates in groups A and B were 95 and 93% (P = 0.99), respectively.

Conclusions
Repeated ESD on scar is an option for treating superficial esophageal SCC with an acceptable rate of adverse events. Because of the low complete resection rate and high local failure compared with conventional ESD, strict endoscopic follow-up is required after repeated esophageal ESD.
Adjuvant treatment patterns for pT3N0M0 esophageal cancer undergoing surgery
Authors: Pei Su , Huang Jiang-Qiong , Liang Huan-Wei , Liu Yang , Chen Long , Yu Bin-Bin , Huang Wei , Pan Xin-Bin 
Published: March 2024

Summary
To assess adjuvant treatment patterns on survival in patients with pT3N0M0 esophageal cancer who underwent esophagectomy without neoadjuvant chemoradiotherapy. Stage pT3N0M0 esophageal cancer patients were assessed between 2000 and 2020 from the Surveillance, Epidemiology, and End Results databases. Kaplan–Meier analysis was used to compare overall survival (OS) among various treatment patterns. We identified 445 patients: 252 (56.6%) received surgery alone, 85 (19.1%) received surgery+chemoradiotherapy, 80 (18.0%) underwent surgery+chemotherapy, and 28 (6.3%) received surgery+ radiotherapy. For squamous cell carcinoma, surgery+chemoradiotherapy ([hazard ratio] HR = 1.04, 95% confidence interval (CI): 0.65–1.66; P = 0.873), surgery+chemotherapy (HR = 0.72, 95% CI: 0.42–1.22; P = 0.221), and surgery+radiotherapy (HR = 1.33, 95% CI: 0.74–2.39; P = 0.341) had similar OS compared to surgery alone. For adenocarcinoma, surgery+chemoradiotherapy (HR = 0.51, 95% CI: 0.36–0.74; P &lt; 0.001) and surgery+chemotherapy (HR = 0.61, 95% CI: 0.42–0.87; P = 0.006) had better OS compared to surgery alone. However, surgery+radiotherapy had a comparable OS (HR = 0.81, 95% CI: 0.44–1.49; P = 0.495).Adjuvant treatments did not improve survival in stage pT3N0M0 esophageal squamous cell carcinoma patients. In contrast, adjuvant chemoradiotherapy and chemotherapy were recommended for esophageal adenocarcinoma patients.
Leveraging aquatic-terrestrial interfaces to capture putative habitat generalists
Authors: Richards Sarah C , King William L , Sutherland Jeremy L , Bell Terrence H 
Published: March 2024

Abstract
Habitat type is a strong determinant of microbial composition. Habitat interfaces, such as the boundary between aquatic and terrestrial systems, present unique combinations of abiotic factors for microorganisms to contend with. Aside from the spillover of certain harmful microorganisms from agricultural soils into water (e.g. fecal coliform bacteria), we know little about the extent of soil-water habitat switching across microbial taxa. In this study, we developed a proof-of-concept system to facilitate the capture of putatively generalist microorganisms that can colonize and persist in both soil and river water. We aimed to examine the phylogenetic breadth of putative habitat switchers and how this varies across different source environments. Microbial composition was primarily driven by recipient environment type, with the strongest phylogenetic signal seen at the order level for river water colonizers. We also identified more microorganisms colonizing river water when soil was collected from a habitat interface (i.e. soil at the side of an intermittently flooded river, compared to soil collected further from water sources), suggesting that environmental interfaces could be important reservoirs of microbial habitat generalists. Continued development of experimental systems that actively capture microorganisms that thrive in divergent habitats could serve as a powerful tool for identifying and assessing the ecological distribution of microbial generalists.
Impacts of temporal resolution of atmospheric de-aliasing products on gravity field estimation
Authors: Bai Yinglun , Chen Qiujie , Shen Yunzhong , Xiao Yun , Zhang Xingfu 
Published: March 2024

SUMMARY
Despite the increasing accuracies of GRACE (Gravity Recovery and Climate Experiment)/GRACE-FO (GRACE Follow-On) gravity field models through worldwide endeavours, the temporal aliasing effect caused by the imperfect background models used in gravity field modelling is still a crucial factor that degrades the quality of gravity field solutions. Since the important role of temporal resolution of atmospheric de-aliasing models, this paper specifically investigates the influence of temporal resolution on gravity field modelling from the perspectives of frequency, spectral and spatial domains. To this end, we introduced the gravitational acceleration and geoid height derived from the static gravity field GOCO06s in the inner integral. The introduction of the static gravity field has a comparable impact on LRI (Laser Ranging Interferometers) range-rate residuals as the accuracy of the LRI range-rate data, despite its magnitude of being less than 0.1 mm in the spatial domain. This finding also highlights the significance of error level in existing de-aliasing products as a crucial factor that restricts the current accuracy of gravity field solutions. Further analyses show that increasing the temporal resolution from 3 to 1 hr has an insignificant impact on the gravity solutions in both the frequency and spectral domains, which is also smaller than that caused by using different atmospheric data sets. However, in the spatial domain, LRI range-rate residuals can be effectively mitigated in certain regions of the Southern Hemisphere at mid- and high-latitudes by increasing the temporal resolution. Particularly, the discrepancies of mass change estimates brought about by enhancing temporal resolution have distinct characteristics, especially in the Congo River and the Amazon River Basins. The mass changes in terms of equivalent water height derived by using P4M6 filtering show that the maximum root mean square value of spatial differences caused by improving the temporal resolution of the atmospheric de-aliasing models can reach ∼13.4 mm in the subregion of the Congo River Basin. However, using different atmospheric data sets can lead to a maximum difference of ∼16.5 mm. For the Amazon River Basin, the corresponding maximum discrepancy is ∼18.1 mm, and that caused by improving temporal resolution is ∼9.4 mm. We further divide the Congo River Basin into several subregions using a lat-lon regular grid with a spatial resolution of 3°. The subsequent time-series results of mass changes reveal that the maximum contribution of temporal resolution and changes in the atmospheric data sets can reach 11.09 and 21.24 per cent, respectively. This suggests that it is necessary to consider the temporal resolution of de-aliasing products when studying mass changes at a regional scale.
Pyrus betulaefolia ERF3 interacts with HsfC1a to coordinately regulate aquaporin PIP1;4 and NCED4 for drought tolerance
Authors: Zhang Feng , Pan Zhijian , Han Chenyang , Dong Huizhen , Lin Likun , Qiao Qinghai , Zhao Keke , Wu Juyou , Tao Shutian , Zhang Shaoling , Huang Xiaosan 
Published: March 2024

Abstract
Environmental disasters like drought reduce agricultural output and plant growth. Redox management significantly affects plant stress responses. An earlier study found that PbPIP1;4 transports H2O2 and promotes H2O2 downstream cascade signaling to restore redox equilibrium. However, this regulatory mechanism requires additional investigation. In this search, the AP2 domain-containing transcription factor was isolated by screening Y1H from the wild pear (Pyrus betulaefolia) cDNA library, named PbERF3. The overexpression of PbERF3 in pear callus and Arabidopsis enhanced plant resistance to drought and re-established redox balance. The transcripts of the NCEDs gene were upregulated under drought stress. The drought stress-related abscisic acid (ABA) signaling pathway modulates PbERF3. PbERF3 silencing lowered drought tolerance. Furthermore, yeast 2-hybrid, luciferase, bimolecular fluorescence complementation, and co-immunoprecipitation assays verified that PbERF3 physically interacted with PbHsfC1a. The PbERF3-PbHsfC1a heterodimer coordinately bound to PbPIP1;4 and PbNCED4 promoter, therefore activating both the H2O2 and the ABA signaling pathway. This work revealed a novel PbERF3-PbHsfC1a-PbNCED4-PbPIP1;4 regulatory module, in which PbERF3 interacts with PbHsfC1a to trigger the expression of target genes. This module establishes an interaction between the H2O2 signaling component PbPIP1;4 and the ABA pathways component PbNCED4, enabling a response to drought.
Residual life prediction of lithium battery based on hybrid model of WOA–VMD and attention mechanism
Authors: Tao Qiong , Lv Jie , Wu Jia 
Published: March 2024

Abstract
In order to improve the long-term reliability of lithium battery and ensure the safe operation of the system, a forecasting method combining whale optimization algorithm (WOA), variational mode decomposition (VMD) and the Gated Recurrent Unit model with Attention mechanism (GRU-Attention) was proposed. WOA–VMD was used to decompose the battery capacity data into the intrinsic mode component and residual component, which were, respectively, predicted by GRU-Attention, and finally effectively integrated to obtain accurate capacity prediction results. Through the experiments of the Li-ion battery data set of the Advanced Life Cycle Engineering Center of the University of Maryland, the proposed Li-ion battery combination prediction model has high prediction accuracy and stability. This method is a novel combination of advanced technologies and algorithms, and its effectiveness in improving the long-term reliability of lithium batteries has been verified by experiments. This research is of great significance for promoting the development and application of lithium battery technology.
Command filter-based adaptive neural two-bit-triggered containment control for saturated nonlinear multi-agent systems
Authors: Wu Yuhang , Niu Ben , Xu Ning , Zhao Xudong , Ahmad Adil M 
Published: March 2024

Abstract
This paper considers the adaptive two-bit-triggered containment control problem for nonlinear multi-agent systems in the presence of input saturation. Since input saturation occurs frequently in practical systems, which can affect the stability of the multi-agent systems under consideration, an auxiliary design system is introduced to address this issue. Meanwhile, considering limited transmission resources in practical systems, this paper mainly focuses on the triggering condition and the control signal transmission bits, presenting a two-bit-triggered control approach to optimize the utilization of transmission resources. Furthermore, a command filter is introduced into the design process to solve the problem of complexity explosion. The proposed method ensures that all signals of the closed-loop system are bounded and the output signals of all followers converge to a convex hull spanned by the outputs of the leaders. Finally, two simulation examples are provided to verify the validity of the presented control scheme.
Stability and co-existence state traveling wave solution for a general N-dimensional diffusive delayed Lotka-Volterra equation in a cylinder
Authors: Tian Yanling , Shen Shuyuan , Yang Jinji 
Published: March 2024

Abstract
A general $N$-dimensional non-monotone delayed diffusive Lotka–Volterra model is considered in our paper. First, we obtain the global stability of the model subject to Neumann boundary condition by using a small delay result for delayed systems. Second, the limits at $+\infty $ of bounded travelling wave solutions are confirmed by virtue of such global stability. Therefore, the existence of co-existence state travelling wave solutions is established. Finally, an example is given to illustrate the biological significance of the assumptions in the current paper.
No Safe Haven: Operation Condor and Transnational Repression in South America
Authors: Lessa Francesca , Balardini Lorena 
Published: March 2024

Abstract
Transnational repression, i.e., the deliberate targeting of refugees and dissidents by states across borders, is a relatively understudied subject in international relations. This article analyzes why states act together to persecute political opponents abroad and explains variations in such practices. It proposes a theory of cooperation in transnational repression and uses the case study of Operation Condor in the 1970s to test it. Through Operation Condor, South American authoritarian states willingly forewent key aspects of their sovereignty to establish a sophisticated system of cooperation to target dissidents abroad. This scheme was a critical extension of these countries’ domestic-level policies of repression against political opposition and enabled them to target politically active refugees wherever they were located. Exiles were perceived as constituting an existential threat to these autocracies’ survival, given their ability to potentially undermine both their internal and external regime security, which therefore warranted their elimination. We draw on an interdisciplinary methodology, which combines archival research, interviews, trial observation, and the analysis of legal verdicts, alongside conclusions derived from our novel dataset, the Database on South America's Transnational Human Rights Violations (1969–1981).
Maximizing Mentorship Throughout Your Breast Imaging Career
Authors: Mullen Lisa A , Weinfurtner R Jared , Borovicka Kathy M , Hoyt Tamarya L , Letter Haley P , O’Brien Sophia R , Swamy Nayanatara , Vicenti Kerri L , Woodard Stefanie A , Xavier Brian A , Gundry Kathleen R , Merkulov Alex , Margolies Laurie R , Slanetz Priscilla J 
Published: March 2024

Abstract
Unlike many other subspecialties in radiology, breast radiologists practice in a patient-facing and interdisciplinary environment where team building, communication, and leadership skills are critical. Although breast radiologists can improve these skills over time, strong mentorship can accelerate this process, leading to a more successful and satisfying career. In addition to providing advice, insight, feedback, and encouragement to mentees, mentors help advance the field of breast radiology by contributing to the development of the next generation of leaders. During the mentorship process, mentors continue to hone their listening, problem-solving, and networking skills, which in turn creates a more supportive and nurturing work environment for the entire breast care team. This article reviews important mentorship skills that are essential for all breast radiologists. Although some of the principles apply to all mentoring relationships, ensuring that every breast radiologist has the skills to be both an effective mentor and mentee is key to the future of the profession.
Make Hay While the Sun Shines: an Empirical Study of Maximum Price, Regret, and Trading Decisions
Authors: Brettschneider Julia , Burro Giovanni , Henderson Vicky 
Published: March 2024

Abstract
Time-constant trading thresholds are optimal for a large class of preferences and asset price dynamics, including, Expected Utility and the S-shaped reference-dependent utility of Prospect Theory. Such thresholds imply selling stocks at the maximum price since purchase. We use a large discount brokerage dataset containing US households’ trading records between 1991 and 1996 to document that in 31.6% of cases the stocks sold for a gain are sold on the day when the maximum since purchase occurs. However, not all stocks are sold at a maximum since purchase and the propensity to sell changes depending on how far in time and price the stock is with respect to this past maximum. We find that the propensity to sell initially increases as the price is closer to the past maximum but it then decreases when the price gets in the closest region to the past maximum, leading to an inverse U-shape; and that investors are less likely to sell a gain, the further away in time the maximum price occurred. Studying the joint effect of price and time distance, we find that the propensity to sell is highest at low time distance and high price distance from the maximum since purchase. We relate these findings to regret, belief updating, and attention.
Characterization and correlation of the probing behaviors of Macrosteles quadrilineatus (Hemiptera: Cicadellidae) with electropenetrography (EPG) waveforms
Authors: Romero Berenice , Rojek Joanna , Wist Tyler , Prager Sean M 
Published: March 2024

Abstract
Aster leafhopper (Hemiptera: Cicadellidae: Macrosteles quadrilineatus Forbes) is a polyphagous insect species that migrates into the upper Midwest of the United States and the Western Canadian Prairies. Populations of this insect are associated with the transmission of a plant pathogen (Candidatus Phytoplasma asteris, 16SrI) to several annual crops and perennial plant species. Previous studies suggest that aster leafhoppers can sometimes prefer less suitable hosts for their development and survival, yet it is unclear if this lower performance on certain plant species is associated with reduced or impaired probing behaviors due to characteristics of the plants. To characterize the probing behaviors of aster leafhoppers, direct current electropenetrography recordings of male and female adults on barley (Polaes: Poaceae: Hordeum vulgare L.) were combined with plant histology, allowing the identification of nine waveforms and their proposed biological meanings. For each waveform, the number of waveform events per insect (NWEI), the waveform duration per insect (WDI), the waveform duration per event per insect (WDEI), and the percentage of recording time were calculated and statistically compared between sexes. Male and female aster leafhoppers exhibited similar behavioral responses for most of these variables, except for the NWEI for waveforms associated with nonprobing activities and the pathway phase. In these cases, male aster leafhoppers exhibited a higher number of events than females. Comparison of the proposed waveforms in this study with previous work on other hemipteran species provided additional support to the interpretation of the biological activities associated with each waveform.
Novel B-cell subsets as potential biomarkers in idiopathic inflammatory myopathies: insights into disease pathogenesis and disease activity
Authors: Reyes-Huerta Raúl F , Mandujano-López Vladimir , Velásquez-Ortiz Ma Guadalupe , Alcalá-Carmona Beatriz , Ostos-Prado María J , Reyna-Juárez Yatzil , Meza-Sánchez David E , Juárez-Vega Guillermo , Mejía-Domínguez Nancy R , Torres-Ruiz Jiram , Gómez-Martín Diana , Maravillas-Montero José L 
Published: March 2024

Abstract
Idiopathic inflammatory myopathies are a heterogeneous group of rare autoimmune disorders characterized by progressive muscle weakness and the histopathologic findings of inflammatory infiltrates in muscle tissue. Although their pathogenesis remains indefinite, the association of autoantibodies with clinical manifestations and the evidence of high effectiveness of depleting therapies suggest that B cells could be implicated. Therefore, we explored the landscape of peripheral B cells in this disease by multiparametric flow cytometry, finding significant numerical decreases in memory and double-negative subsets, as well as an expansion of the naive compartment relative to healthy controls, that contribute to defining disease-associated B-cell subset signatures and correlating with different clinical features of patients. Additionally, we determined the potential value of these subsets as diagnostic biomarkers, thus positioning B cells as neglected key elements possibly participating in idiopathic inflammatory myopathy onset or development.
Postmortem neuropathology in early Huntington disease
Authors: Hedreen John C , Berretta Sabina , White III Charles L 
Published: March 2024

Abstract
Two aspects of the neuropathology of early Huntington disease (HD) are examined. Neurons of the neostriatum are counted to determine relative loss in striosomes versus matrix at early stages, including for the first time in preclinical cases. An immunohistochemical procedure is described that tentatively distinguishes early HD from HD mimic disorders in postmortem brains. Counts of striatal projection neurons (SPNs) in striosomes defined by calbindin immunohistochemistry versus counts in the surrounding matrix are reported for 8 Vonsattel grade 0 (including 5 premanifest), 8 grade 1, 2 grade 2 HD, and for 8 control postmortem brains. Mean counts of striosome and matrix SPNs were significantly lower in premanifest grade 0 versus controls, with striosome counts significantly lower than matrix. In 8 grade 1 and 2 grade 2 brains, no striosomes with higher SPN counts than in the surrounding matrix were observed. Comparing dorsal versus ventral neostriatum, SPNs in dorsal striosomes and matrix declined more than ventral, making clear the importance of the dorsoventral site of tissue selection for research studies. A characteristic pattern of expanded polyglutamine-immunopositive inclusions was seen in all HD cases. Inclusions were always present in some SPNs and some pontine nucleus neurons and were absent in Purkinje cells, which showed no obvious cell loss.