bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pd‐Catalyzed Aerobic Oxidative Coupling of Anilides with Olefins Through Regioselective C—H Bond Activation.
Authors: Wang Jia‐Rui , Yang Chu‐Ting , Liu Lei , Guo Qing‐Xiang 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A New and Efficient One‐Pot Synthesis of Aromatic Alkynyl Ketones from Aromatic Esters.
Authors: Yim Sang Jun , Kwon Chan Ho , An Duk Keun 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Intramolecular [2 + 2]‐Cycloaddition of Propargylic 2,3‐Allenoates for the Efficient Synthesis of 3‐Oxabicyclo[4.2.0]octa‐1(8),5‐dien‐4‐ones: A Dramatic Substituent Effect.
Authors: Jiang Xuefeng , Ma Shengming 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Electrogenerated Base Promoted Synthesis of Tetrahydrobenzo[b]pyran Derivatives.
Authors: Fotouhi Lida , Heravi Majid M. , Fatehi Azadeh , Bakhtiari Khadijeh 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis and Characterization of Quinoline Derivatives via the Friedlaender Reaction.
Authors: Yang Dingqiao , Jiang Kailing , Li Jingning , Xu Feng 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Chemo‐ and Regioselective Three‐Component Dihydropyrimidinone Synthesis.
Authors: Bailey Chris D. , Houlden Chris E. , Bar Gregory L. J. , Lloyd‐Jones Guy C. , Booker‐Milburn Kevin I. 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Formation of Stable Enols from 1,4‐Dilithio‐1,3‐dienes and Acid Chlorides by a Dearomatization/Michael Addition/Rearomatization Domino Process.
Authors: Hu Qiaoshu , Wang Chao , Li Dongzhen , Xi Zhenfeng 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Discovery of (S)‐2‐((S)‐2‐(3,5‐Difluorophenyl)‐2‐hydroxyacetamido)‐N‐( (S,Z)‐3‐methyl‐4‐oxo‐4,5‐dihydro‐3H‐benzo[d] [1,2]diazepin‐5‐yl)propanamide (BMS‐433796): A γ‐Secretase Inhibitor with Aβ Lowering Activity in a Transgenic Mouse Model of Alzheimer′s Disease.
Authors: Prasad C. V. C. , et al. et al. 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Simple Synthesis of 2‐C‐Branched Glycoacetic Acids.
Authors: Yin Jian , Spindler Juergen , Linker Torsten 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Reaction of Methyl‐4‐methylene‐2,3‐O‐isopropylidene‐β‐D‐ribofuranoside with N‐Bromosuccinimide in Aqueous Tetrahydrofuran.
Authors: Ivanova N. A. , Valiullina Z. R. , Shitikova O. V. , Miftakhov M. S. 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Design, Synthesis, and Antiviral Evaluation of Some 3′‐Carboxymethyl‐3′‐deoxyadenosine Derivatives.
Authors: Peterson Matt A. , Ke Pucheng , Shi Houguang , Jones Carl , McDougall Brenda R. , Robinson W. Edward Jr. 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Thuggacins, Macrolide Antibiotics Active Against Mycobacterium tuberculosis: Isolation from Myxobacteria, Structure Elucidation, Conformation Analysis and Biosynthesis.
Authors: Steinmetz Heinrich , Irschik Herbert , Kunze Brigitte , Reichenbach Hans , Hoefle Gerhard , Jansen Rolf 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Dibromomethane as One‐Carbon Source in Organic Synthesis: Formal Total Synthesis of (.+‐.)‐Nephrosteranic Acid (VI)
Authors: Hon Yung‐Son , Hsieh Cheng‐Han , Chen Hsien‐Fan 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Two New Bisorbicillinoids Isolated from a Deep‐Sea Fungus, Phialocephala sp. FL30r.
Authors: Li Dehai , Wang Fengping , Cai Shengxin , Zeng Xiang , Xiao Xiang , Gu Qianqun , Zhu Weiming 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Discovery of Novel Dialkyl Substituted Thiophene Inhibitors of HCV by in silico Screening of the NS5B RdRp.
Authors: Louise‐May Shirley , Yang Wengang , Nie Xingtie , Liu Dongmei , Deshpande Milind S. , Phadke Avinash S. , Huang Mingjun , Agarwal Atul 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
(S)‐ and (R)‐5‐Pyrrolidin‐2‐yl‐1H‐tetrazoles: Enantiomeric Organocatalysts of Broad Utility in Organic Synthesis
Authors: Longbottom Deborah A. , Franckevicius Vilius , Ley Steven V. 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Thione—Thiol Rearrangement: Miyazaki—Newman—Kwart Rearrangement and Others
Authors: Zonta Cristiano , De Lucchi Ottorino , Volpicelli Raffaella , Cotarca Livius 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Molecular Basis for the Inhibition of Anticancer Agents‐Induced Apoptosis by Thymidine Phosphorylase
Authors: Ikeda Ryuji 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Allosteric Bindings of Hydrindacene‐Based Receptors with Benzenediols: Regulation by the Cooperative Amide Hydrogen‐Bonding
Authors: Kawai Hidetoshi 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Intermolecular chiral recognition processes probed by chiroptical luminescence
Authors: Hopkins Todd A. , Metcalf David H. , Richardson Frederick S. 
Published: October 2007

AbstractEnantiopreferential energy transfer processes between dissymmetric lanthanide and transition metal complexes dissolved in acetonitrile are studied using chiroptical luminescence techniques. The energy donors (luminophores) in this study are a racemic mixture of Ln(dpa) complexes (where Ln = Eu3+ or Tb3+ and dpa = 2,6‐pyridinedicarboxylate), and the energy acceptors (quenchers) are an enantiomerically‐resolved population of Co(R,R‐chxn) (where R,R‐chxn = trans‐1R,2R‐diaminocyclohexane) complexes. The luminophores are dissolved in acetonitrile as (NEt4)3[Ln(dpa)3] (where NEt4 = tetraethlylammonium) and (NBu4)[Ln(dpa)3] (where NBu4 = tetrabutylammonium) salts. The unquenched luminescence lifetimes are reported for both Eu(dpa) and Tb(dpa) in acetonitrile over the range 263–333 K, and these results are compared to luminescence lifetimes in aqueous solution. Time‐resolved chiroptical luminescence measurements of enantiopreferential quenching kinetics are reported for samples with Eu(dpa) and Co(R,R‐chxn) in acetonitrile over 263–333 K range. These results are analyzed using a phenomenological quenching kinetics model, and the results are compared to results in aqueous solution. These comparisons show that the overall Eu‐Co luminescence quenching efficiency is reduced in acetonitrile vs. aqueous samples, because the salts of (NX4)3[Eu(dpa)3] are not completely dissociated in acetonitrile. However, the enantiopreference exhibited is identical in acetonitrile vs. aqueous solution. Chirality, 2008. © 2007 Wiley‐Liss, Inc.
Aberrant methylation of E‐cadherin and H‐cadherin genes in nonsmall cell lung cancer and its relation to clinicopathologic features
Authors: Kim Dong Sun , Kim Mi Jin , Lee Ji Yun , Kim Young Zoo , Kim Eun Jin , Park Jae Yong 
Published: October 2007

AbstractBACKGROUND.Lung cancer is the leading cause of cancer deaths worldwide. The epigenetic inactivation of certain genes by aberrant promoter methylation plays an important role in the pathogenesis of lung cancer. In addition, DNA hypermethylation is an extremely promising cancer marker. Cadherins are cell adhesion molecules that modulate the epithelial phenotype and regulate tumor invasion. Although the aberrant methylation of E‐cadherin (CDH1) or H‐cadherin (CDH13) genes has been reported in lung cancer, to the authors' knowledge, the relation between the concurrent hypermethylation in E‐cadherin and H‐cadherin has not been explored to date.METHODS.The authors investigated the methylation status of the promoter region of human E‐cadherin and H‐cadherin genes in resected samples of primary nonsmall cell lung cancer (NSCLC) using methylation‐specific polymerase chain reaction (MSP) analysis and correlated the results with clinicopathologic characteristics. The methylation status of the promoter regions of the E‐cadherin and H‐cadherin genes was examined by using nested MSP in 88 primary lung cancers and paired adjacent normal tissues. Data were compared with clinicopathologic features.RESULTS.The frequency of methylation in neoplastic and corresponding nonneoplastic lung tissues was 30 of 88 tissue samples (34.1%) and 5 of 88 tissue samples (5.7%) for E‐cadherin and 26 of 88 tissue samples (29.5%) and 7 of 88 tissue samples (8%) for H‐cadherin, respectively. In addition, in 9 patients (10.2%), both genes were methylated. Although there was no significant difference in the overall survival of patients according to the methylation pattern of the E‐cadherin gene alone or the H‐cadherin gene alone, patients with NSCLC who had hypermethylation of both genes had a significantly longer overall survival. However, no correlation was observed between their methylation status and any other clinicopathologic factors.CONCLUSIONS.The current findings suggested that simultaneous methylation of the E‐cadherin and H‐cadherin genes occurs in a subset of NSCLCs and may be used as a prognostic marker for patients with NSCLC. However, further studies with large numbers of patients will be needed to confirm the findings. Cancer 2007. © 2007 American Cancer Society.
Intermittent chemotherapy in patients with metastatic androgen‐independent prostate cancer
Authors: Beer Tomasz M. , Ryan Christopher W. , Venner Peter M. , Petrylak Daniel P. , Chatta Gurkamal S. , Ruether J. Dean , Chi Kim N. , Young James , Henner W. David 
Published: October 2007

AbstractBACKGROUND.Survival in patients with metastatic, chemotherapy‐naive, androgen‐independent prostate cancer (AIPC) is improved with 10 to 12 cycles of docetaxel‐containing chemotherapy but further management is undefined. In the current study, the authors examined retreatment with the same regimen after a treatment holiday.Methods.Patients treated with docetaxel at a dose of 36 mg/m2 plus either high‐dose calcitriol (DN‐101; 45 μg) or placebo administered weekly for 3 of every 4 weeks could suspend treatment if their serum prostate‐specific antigen (PSA) level was reduced ≥50% and reached a level ≤4 ng/mL. PSA was monitored every 4 weeks (computed tomography scans were administered every 8 weeks in patients with measurable disease) during the treatment holiday. Treatment was resumed when the serum PSA rose by ≥50% and was ≥2 ng/mL or when there was other evidence of disease progression. The study was not powered to compare treatment holiday outcomes between the 2 arms.RESULTS.A total of 250 patients were randomized 1:1. Overall, 18% of patients (20% in the high‐dose calcitriol group and 16% in the placebo group) entered the intermittent chemotherapy arm. The median duration of the first chemotherapy holiday was 18 weeks (range, 4%70 weeks). On resumption of treatment after the first holiday, 45.5% of evaluable patients responded with a ≥50% reduction in serum PSA from their postholiday baseline, 45.5% met the criteria for stable PSA for at least 12 weeks, and 9.1% of patients developed disease progression.CONCLUSIONS.To the authors' knowledge, the current study is the first report of intermittent chemotherapy in patients with AIPC who were prospectively tested in a large multi‐institutional trial. This strategy results in a clinically significant duration of chemotherapy holidays and can be offered to a minority of patients. At the time of retreatment, the majority of patients again respond to treatment or their PSA levels stabilized. Additional studies of intermittent chemotherapy are needed to better characterize the optimal patient population and the optimal approach. Cancer 2008. © 2007 American Cancer Society.
Room Temperature COad Desorption/Exchange Kinetics on Pt Electrodes—A Combined In Situ IR and Mass Spectrometry Study
Authors: Heinen Martin , Chen Yan‐Xia , Jusys Zenonas , Behm Rolf Jürgen 
Published: October 2007

AbstractThe room temperature desorption and exchange of CO in a saturated CO adlayer on a Pt electrode, at potentials far below the onset of oxidation, was investigated by isotope labeling experiments, using a novel spectroelectrochemical setup, which allows the simultaneous detection of adsorbed species by in situ IR spectroscopy and of volatile (side) products and reactants by online mass spectrometry under controlled electrolyte flow conditions. Time‐resolved IR spectra show a rapid, statistical exchange of pre‐adsorbed 13COad by 12COad in 12CO containing electrolyte; mass spectrometric data reveal first‐order exchange kinetics, with the rate increasing with CO partial pressure. The increasing COad desorption rate in equilibrium with a CO containing electrolyte is explained by a combination of an increasing COad coverage upon increasing the CO pressure, and a decrease of the CO adsorption energy with coverage, due to repulsive COad–COad interactions.
Orchestration of pathogen recognition by inflammasome diversity: Variations on a common theme
Authors: Martinon Fabio 
Published: October 2007

AbstractInnate immunity is a crucial part of the immune system, capable of mounting specific host responses against distinct pathogens. An integral component of the innate immune system is a network of pathogen recognition receptors, which are present at the surface of the cell or in the cytoplasm. Nucleotide oligomerization domain (Nod)‐like receptors form the largest known family of intracellular innate immune sensors of microbes and danger signals that initiate early host responses. Some Nod‐like receptors, such as NALP, NAIP and IPAF, form molecular machines termed inflammasomes, which are involved in the activation of inflammatory cytokines such as IL‐1β and IL‐18. The diversity and the role of the different types of inflammasomes remain poorly defined. In this issue of the European Journal of Immunology, it is reported that the Gram‐negative human pathogen Pseudonomas aeruginosa specifically activates an IPAF inflammasome. This finding, in combination with other recently published reports, reveals how different pathogens engage distinct types of inflammasomes, further highlighting the diversity and plasticity of inflammasomes activation.See accompanying article: http://dx.doi.org/10.1002eji200737532
Cover Picture: The cover image features a frozen section from an embryonic day 16 mouse spleen stained by immunofluorescence to demonstrate the presence and location of lymphoid tissue inducer (LTi) cells. Withers et al. (pp. 3240–3245) show that these cells form the focus of lymphocyte accumulation in the developing mouse spleen. Red staining for CD45 marks haemopoietic cells, green shows IL‐7Rα expression, and CD4 expression is in blue. LTi cells that express all markers (in white) cluster around blood vessels in the embryonic spleen where signalling to stromal cells initiates lymphocyte recruitment. – Eur. J. Immunol. 11/2007
Authors: Withers David R. , Kim Mi‐Yeon , Bekiaris Vasileios , Rossi Simona W. , Jenkinson William E. , Gaspal Fabrina , McConnell Fiona , Caamano Jorge H. , Anderson Graham , Lane Peter J. L. 
Published: October 2007

AbstractCD4+CD3– lymphoid tissue inducer (LTi) cells are crucial for the development and organisation of lymph nodes and gut associated lymphoid tissues. In this report, we characterise their appearance in the developing spleen and highlight their importance in relation to the development of splenic T cell zones. LTi cells were detected in embryonic spleen from embryonic day 13, although their progenitors were present at embryonic day 12. These cells clustered initially around splenic blood vessels in a lymphotoxin (LT)‐independent manner, but up‐regulation of VCAM‐1 expression on stromal cells associated with the blood vessels was LT dependent. After birth, T cell colonisation of these clusters to form nascent white pulp areas was also LT dependent. Transfer experiments reconstituting RAG–/– mice with either WT or LTα–/– splenocytes demonstrated that lymphocyte expression of LT was not essential for the organisation of a discrete CD3+ T cell zone with localised podoplanin and CCL21 expression. Our studies indicate that a combination of LT signals from LTi cells and LT‐independent signals from lymphocytes is sufficient for expression of podoplanin and CCL21 on splenic T cell zone stroma and subsequent T cell organisation.
Childhood experiences of being bullied and teased in the eating disorders
Authors: Sweetingham Rachel , Waller Glenn 
Published: October 2007

AbstractEmpirical studies have found associations between eating pathology and childhood experiences of being bullied and teased about appearance. However, the nature of these links is not clear. This study investigated the possible links between such experiences and eating disorders, focusing on the potential mediating role of two socially oriented emotions–shame and social anxiety. Ninety‐two eating‐disordered women completed measures of social anxiety, shame, eating pathology and childhood experiences of being bullied and teased about their appearance (by peers and family). There was a specific relationship between teasing by peers about appearance and body dissatisfaction, which was mediated by shame. These findings support existing evidence regarding the associations between trauma and eating pathology. They suggest that clinicians need to consider the potential role of teasing by peers about appearance and shame when understanding body dissatisfaction. Further research is needed to determine if the model proposed here reflects true causal links. Copyright © 2007 John Wiley & Sons, Ltd and Eating Disorders Association.
Positive‐definiteq‐families of continuous subcell Darcy‐flux CVD(MPFA) finite‐volume schemes and the mixed finite element method
Authors: Edwards Michael G. , Pal Mayur 
Published: October 2007

AbstractA new family of locally conservative cell‐centred flux‐continuous schemes is presented for solving the porous media general‐tensor pressure equation. A general geometry‐permeability tensor approximation is introduced that is piecewise constant over the subcells of the control volumes and ensures that the local discrete general tensor is elliptic. A family of control‐volume distributed subcell flux‐continuous schemes are defined in terms of the quadrature parametrizationq(Multigrid Methods. Birkhauser: Basel, 1993;Proceedings of the 4th European Conference on the Mathematics of Oil Recovery, Norway, June 1994;Comput. Geosci.1998;2:259–290), where the local position of flux continuity defines the quadrature point and each particular scheme. The subcell tensor approximation ensures that a symmetric positive‐definite (SPD) discretization matrix is obtained for the base member (q=1) of the formulation. The physical‐space schemes are shown to be non‐symmetric for general quadrilateral cells. Conditions for discrete ellipticity of the non‐symmetric schemes are derived with respect to the local symmetric part of the tensor. The relationship with the mixed finite element method is given for both the physical‐space and subcell‐spaceq‐families of schemes.M‐matrix monotonicity conditions for these schemes are summarized. A numerical convergence study of the schemes shows that while the physical‐space schemes are the most accurate, the subcell tensor approximation reduces solution errors when compared with earlier cell‐wise constant tensor schemes and that subcell tensor approximation using the control‐volume face geometry yields the best SPD scheme results. A particular quadrature point is found to improve numerical convergence of the subcell schemes for the cases tested. Copyright © 2007 John Wiley & Sons, Ltd.
A robust methodology for RANS simulations of highly underexpanded jets
Authors: Lehnasch G. , Bruel P. 
Published: October 2007

AbstractThis work aims at developing/combining numerical tools adapted to the simulation of the near field of highly underexpanded jets. An overview of the challenging numerical problems related to the complex shock/expansion structure encountered in these flows is given and an efficient and low‐cost numerical strategy is proposed to overcome these, even on short computational domains. Based on common upwinding algorithms used on unstructured meshes in a mixed finite‐volume/finite‐element approach, it relies on an appropriate utilization of zonal anisotropic remeshing algorithms. This methodology is validated for the whole near field of cold air jets issuing from axisymmetric convergent nozzles and yielding various underexpansion ratios. In addition, the most usual corrections of thek–ε model used to take into account the compressibility effects on turbulence are precisely assessed. Copyright © 2007 John Wiley & Sons, Ltd.