bluuebunny/crossref_metadata_2025_split huggingface dataset:
Congenital cystic adenomatoid malformation of the lung and pulmonary tumorlets in an adult
Authors: Chen Karl T. K. 
Published: February 2007

AbstractCongenital cystic adenomatoid malformation of the lung is usually diagnosed in neonates. It is rare in children beyond infancy and only two cases have been diagnosed in adults. The third adult case in which the disease was associated with pulmonary tumorlets is described.
Hepatic staging in operable breast cancer: A reappraisal from a prospective study
Authors: Colizza S. , Lupattelli R. , De Fazio S. , Preziosi P. , Karakaci F. , Cucchiara C. 
Published: February 2007

AbstractA consecutive series of 100 patients affected by breast cancer and referred for surgical treatment were studied for the eventual spread of the tumour to the liver (echography, carcinoembryonic antigen [CEA], hepatic enzymes). Hepatic echography was positive in five cases: two also had bone and skin metastases at the time of diagnosis, and one was a case of remastectomy (these three patients died rather quickly of the disease); the remaining two patients are free of the disease 24 months after surgery and thus should be considered false‐positive cases. Hepatic enzymes were not significant. The same was true for CEA except in nine cases with levels > > 20 ng/ml (six of these had early local and/or distant metastases). It is concluded that the usefulness of routine hepatic echography before loco‐regional treatment of breast cancer is rather limited. CEA > > 20 ng/ml may be useful prognostically.
Wilms' tumor—treatment and results: A five‐decade experience
Authors: Allen James E. , Brecher Martin J. , Karp Melvyn P. , Cooney Donald R. , Jewett Theodore C. 
Published: February 2007

AbstractDuring the past 53 years, 105 patients with Wilms' Tumor have been treated at the Children's Hospital of Buffalo. Prospective and retrospective staging of these cases has allowed comparison with other reported series. All‐stage survival improved from 37% with operation alone to 46% with operation and planned radiotherapy. During the past 22 years, with the addition of adjunctive chemotherapy, all‐stage survival is now 80% with lesser stage survival approaching 100%. Participation in the cooperative National Wilms' Tumor Study has brought the most effective proven treatment to the patient in the shortest period of time.
Juxtadrenal schwannoma: Verification of the diagnosis by immunohistochemical and ultrastructural studies
Authors: Oliver William R. , Reddick Robert L. , Gillespie G. Yancey , Siegal Gene P. 
Published: February 2007

AbstractSolitary schwannomas arising in the Juxtadrenal region are exceedingly rare. A middle‐aged woman with a confusing clinical course was found to have a solid periadrenal mass, which was surgically excised. The gross and light microscopic appearance of the tumor was suggestive but not diagnostic of this entity. However, electron microscopic evaluation of the neoplasm revealed prominent basal lamina and interdigitating cellular processes characteristic of a schwannoma. The diagnosis of schwannoma was further supported by the demonstration of S‐100 protein, type IV (basement membrane) collagen, and laminin immunoreactivity by immunohistochemical techniques. The use of these special studies to arrive at the diagnosis in this case and in the larger context in the diagnosis of rare adrenal and periadrenal tumors of uncertain origin is fully discussed.
Adrenal cortical carcinoma: Case report
Authors: Sipio James C. , Rohner Thomas J. , Drago Joseph R. 
Published: February 2007

AbstractAdrenal cortical carcinoma is a rare malignant tumor, comprising only 0.02 to 0.04% of all cancers [Nader et al, Cancer 52:707–11, 1983; Didolkar et al, Cancer 47:2153–61, 1981; Hajjar et al, Cancer 35:549–54, 1975]. The mean age of presentation for females is 36.6 years and for males, 48 years. In general, women have a higher percentage of functioning adrenal tumors. Functional tumors are hormonally active with excess steroid production in serum and urine with associated clinical signs and symptoms.
Skin cancer caused by grenz rays
Authors: Dabski Krzysztof , Stoll Howard L. 
Published: February 2007

AbstractA 30‐year‐old woman developed chronic radiodermatitis and five squa‐mous cell carcinomas within 7 years following a 16‐year period of repeated grenz irradiations given to her psoriasis. The estimated cumulative dose of grenz radiation was approximately 3,000 rads (r) to each treated area.This case, illustrating a rather underestimated carcinogenic potential of grenz rays, is interpreted in light of the available literaure on the subject. The technical bases of grenz ray therapy are also briefly reviewed.
Comparative studies of chemotherapy of human tumor cells in vitro by tritiated thymidine uptake inhibition and soft agar clonogenic assay
Authors: Zirvi Karimullah A. , Hill George J. , Hill Helene Z. 
Published: February 2007

AbstractA rapid nonsterile short‐term assay has been investigated in which percent inhibition of incorporation of the DNA precursor (3H)‐thymidine is measured following exposure of tumor cells to the test drugs. To evaluate the usefulness of the short‐term assay in providing a rapid reliable assessment of chemotherapeutic response, the short‐term assay was compared with the soft agar clonogenic assay. Sensitivity to five anticancer drugs was compared using three human tumor cell lines (epidermoid carcinoma of the oral cavity, pancreatic carcinoma, and bladder carcinoma). The short‐term assay produced results that were similar to results of the clonogenic assay in two of the three tumors tested, for three drugs (cis‐platin, doxo‐rubicin, and BCNU), but did not detect responses to two antimetabolites (5‐FU and MTX) in any tumor. Further studies of this short‐term assay should focus on alkylating agents and other nonantimetabolites.
Combined occurrence of third ventricular germinoma and hypothalamic mixed glioma
Authors: Shuangshoti Samruay 
Published: February 2007

AbstractA unique combination of occurrence of the 3rd ventricular germinoma and hypothalamic cystic mixed astrocytoma and oligodendroglioma is encountered in a 15‐year‐old man who presented clinically with stunted growth of the body, diabetes insipidus, and stupor. The germinoma was diagnosed by biopsy but the hypothalamic glioma was discovered at autopsy. Immunohistochemical localization of glial fibrillary acidic protein (GFAP) in the neoplastic cells confirmed the gliomatous nature of the hypothalamic lesion. The probability of multiple tumors should be kept in mind in dealing with intracranial neoplasms in order that the patient will be properly diagnosed and managed.
Low‐dose (diagnostic‐like) X‐ray as a cocarcinogen in mouse colon carcinoma
Authors: Weinerman B. H. , Orr K. B. , Lu L. , Rogers A. 
Published: February 2007

AbstractTo test the hypothesis that low‐dose (diagnostic‐like) radiation may play the part of a cocarcinogen in inflammatory bowel disease, we used four groups of BALB/C mice, (a control, dimethylhydrazine, dimethylhydrazine plus low‐dose radiation, and low‐dose radiation). We found no protective or carcinogen effects of the radiation in combination with dimethylhydrazine compared to dimethylhydrazine alone. This type of negative experimental finding is important in that individuals with inflammatory bowel disease have many diagnostic x‐rays throughout life.
A case of midgut carcinoid with breast metastasis and cellular localization of serotonin and substance P.
Authors: Ahlman H. , Larsson I. , Grönstad K. , Tisell L‐E. , Dahlström A. 
Published: February 2007

AbstractA case of midgut carcinoid with breast metastasis is reported. Hepatic metastases stored large amounts of serotonin as demonstrated by the Falck‐Hillarp technique. Immunocytochemically serotonin and substance P, which may co‐exist in gut enterochromaffin cells, were demonstrated in separate populations of tumor cells both in the hepatic and mammary neoplasms.
Prophylaxis of complications after urological abdominal surgery by substitution of plasma proteins
Authors: Bauer Hartwig W. , Schmiedt Egbert 
Published: February 2007

AbstractA prospective randomized trial on 94 patients undergoing urological‐abdominal surgery has been carried out to evaluate the effect of postoperatively administered plasma proteins. A significant difference in the incidence of bronchopulmonary complications has been found between the treatment group and the control group. This may be due to the substitution of α1‐antitrypsin as indicated by assaying α‐antitrypsin activity. A positive trend, but no significant differences, could be demonstrated for wound healing and the need for antibiotics, postoperatively.
Thyroid hormone administration in irradiated patients
Authors: Murphy E. Dennis , Scanlon Edward F. , Garces Rafael M. , Khandekar Janardan D. , Bailey Lisa 
Published: February 2007

AbstractIn a recall clinic for patients at risk for thyroid carcinoma due to a history of radiation in infancy or childhood, a group of patients were randomly offered prospective suppressive L‐thyroxine therapy and matched to a radiated nontreated group. With an average of more than two years' follow‐up, the thyroid hormone‐treated radiated group developed fewer nodules and abnormalities to palpation and also had a statistically significant lessening of minimal palpable abnormalities compared to the nonthyroxine‐treated radiated group.
Adjuvant chemo‐lmmunotherapy in stage II carcinoma of the breast
Authors: Giuliano Armando E. , Sparks Frank C. , Patterson Karen , Spears Irene , Morton Donald L. 
Published: February 2007

AbstractFrom July of 1974 to June of 1978, 131 patients with Stage II carcinoma of the breast were randomly assigned to one of three treatment arms in order to assess the efficacy of adding immunotherapy to adjuvant chemotherapy. All patients had metastases in the axillary lymph nodes, but no clinical evidence of systemic disease. Prognostic factors were relatively equally distributed among the three treatment arms. All patients received adjuvant chemotherapy consisting of cytoxan, methotrexate, and 5‐fluo‐rouracil (CMF). In addition, patients received adjuvant immunotherapy consisting of Bacille Calmette Guerin (BCG) or BCG plus a tumor cell vaccine. This vaccine was a mixture of allogeneic breast cancer cell lines grown in tissue culture. Fourteen patients receiving tumor cell vaccine developed hepatitis B, leading to the abandonment of this arm of the study. Side effects of chemotherapy were tolerable.No statistically significant difference could be demonstrated in recurrence rate or survival. However, the two groups receiving adjuvant chemo‐immunotherapy had a slightly shorter time to recurrence and lower overall survival. The use of chemo‐immunotherapy as administered in this study did not improve the clinical course of patients with Stage II breast cancer and was associated with significant morbidity.
The demonstration of papilloma virus in cervical dysplasia and/or neoplasia
Authors: Ghosh Luna , Nadimpalli Venkat R. , Ronan Salve G. , Robertson Abel L. 
Published: February 2007

AbstractThirty‐three random biopsy specimens of uterine cervix were studied by immunoperoxidase technique to evaluate the presence of HPV antigen in dysplastic and neoplastic cells. Four cases of mild dysplasia, nine cases of moderate to severe dysplasia, two cases of carcinoma in situ and one case of invasive carcinoma were associated with condylomatous lesions. Intranuclear dark‐brown precipitates were observed in superficial and intermediate zones of the dysplastic epithelium. Positive reaction was seen in condylomatous epithelium associated with neoplasia. No nuclear precipitates were observed in carcinoma cells, but one noncondylomatous lesion with moderate dysplasia showed positive intranuclear staining. These preliminary findings suggest that papilloma viruses may play a role in the development of human cervical neoplasias.
Melanotic primitive neuroectodermal (neuroepithelial) tumor of medulla
Authors: Shuangshoti Samruay 
Published: February 2007

AbstractA 69‐year‐old man had a melanotic primitive neuroectodermal tumor of the medulla displaying various neuroepithelial elements including undifferentiated neuroepithelial cells forming Homer Wright's rosettes as well as neoplastic neuroglia resembling those seen in medulloblastoma. The neuroglial tumor cells were verified by demonstrating glial fibrillary acidic protein (GFAP) in the cells. These findings support the concept that the primitive neuroectodermal tumor and medulloblastoma are similar neoplasms. They have been described by such diverse names as melanotic medulloblastomas and progonomas. Review of 18 reported cases of intracranial melanotic primitive neuroectodermal tumors, including the present one, reveals that they have common pathologic features, are most frequent in the cerebellum and fourth ventricle, often metastasize widely within the neuraxis or even systemically, occur more frequently in children than adults, and strike males more often than females.
Trabecular carcinoma of the skin simulating metastatic disease
Authors: Suster Saul , Ronnen Meyer , Lin Eran , Shewach‐Millet Miriam 
Published: February 2007

AbstractA case of trabecular carcinoma of the skin that resulted in prequarter amputation of the arm for local tumor aggressiveness is presented. The tumor was originally diagnosed as metastatic, most probably neuroblastoma, leading to inadequate local resection that resulted in recurrence with extensive regional nodal metastases. The importance of recognizing trabecular carcinoma as a primary tumor of the skin with a potential for recurrence and metastasis is underscored, primarily since initial total excision with adequate margins of resection has proven in most instances to be curative.
Adenocarcinoma of the breast associated with silicone injections
Authors: Timberlake Gregory A. , Looney George R. 
Published: February 2007

AbstractA 42‐year‐old woman developed inflammatory breast cancer in a breast with “silicone mastitis” 12 years after bilateral breast augmentation with liquid silicone injections. Despite aggressive local and systemic therapy, The patient died of her disease. Breast cancer arising in silicone‐injected breasts is reported infrequently, and physicians caring for patients with silicone breast injection augmentation should be aware of this potentially fatal association with breast cancer.
Histopathological evaluation of hyperthermochemo radiotherapy for carcinoma of the esophagus
Authors: Sugimachi Keizo , Kai Hidenobu , Matsufuji Hidemasa , Ueo Hiroaki , Inokuchi Kiyoshi 
Published: February 2007

AbstractThe effectiveness of preoperative hyperthermo‐chemo‐radiotherapy for 25 patients with carcinoma of the esophagus was histopathologically compared with findings in 104 patients treated preoperatively with irradiation only. The preoperative hyperthermo‐chemo‐radiotherapy increased the rate of “markedly effective” in the resected tissue, when compared with findings in cases of irradiation only. With regard to long survival rates, The 5‐year survival rates of patients classed as “markedly effective” with preoperative combined therapy exceeded events in patients classed as “moderately effective,” and “ineffective,” with statistical significance. Preoperative hyperthermo‐chemo‐radiotherapy is the recommended treatment for patients with carcinoma of the esophagus.
A pleomorphic hepatocellular carcinoma with biochemical features of fibrolamellar hepatocellular carcinoma
Authors: Buamah P. K. , McArdle P. , Bennett M. , James O. F. W. , Lendrum R. 
Published: February 2007

AbstractA case of pleomorphic hepatocellular carcinoma with biochemical characteristics similar to those of fibrolamellar carcinoma is described. During chemotherapy there was a marked disorder of vitamin B12 metabolism.
Squamous cell carcinoma of the rectum: A multimodality approach
Authors: Lafreniere Rene , Ketcham Alfred S. 
Published: February 2007

AbstractA 60‐year‐old homosexual male with a diagnosis of squamous cell carcinoma of the rectum, arising 7 cm from the dentate line, was treated with a rectal perserving multimodality approach consisting of excisional biopsy and chemotherapy with 5‐fluorouracil (5‐FU) and mitomycin‐C with concomitant administration of radiation therapy to the tumor and pelvic nodal bearing areas. The patient has remained disease‐free with full preservation of anorectal function on follow‐up at 2 years. This approach to a difficult and unusual problem is recommended as a first line of therapy rather than surgical resection if 1) it is deemed that the patient can tolerate a combination of chemo and radiation therapy and 2) the patient will be able to participate in a long‐term follow‐up.
Testicular neoplasm diagnosed by ultrasound
Authors: Senay Bruce A. , Stein Barry S. 
Published: February 2007

AbstractThe diagnosis of testicular cancer is usually made by the findings of a testicular mass on physical examination. in rare cases a young man will present with retroperitoneal nodes and a normal testicular examination. in such cases a testicular ultrasound may localize the testis which harbors a subclinical neoplasm. in addition serum markers of B‐HCG and AFP are essential. As a screening procedure a urine pregnancy test is helpful, since it can be obtained quickly while quantitative B‐HCG and APF results are delayed.
Small bowel lymphoma associated with AIDS
Authors: Collier Paul E. 
Published: February 2007

AbstractPatients with the Acquired Immunodeficiency Syndrome (AIDS) are known to be at increased risk for developing malignancy; however, The spectrum that these malignancies encompass has not been fully defined. An unusual case of a 32 year old homosexual male with AIDS who developed two spontaneous small bowel perforations is presented. The diagnosis of primary histiocytic lymphoma of the small intestine was established only after his second operation.
The syndrome of inappropriate antidiuretic hormone secretion associated with induction chemotherapy for squamous cell carcinoma of the head and neck
Authors: Hayes Daniel F. , Lechan Ronald M. , Posner Marshall R. , Weichselbaum Ralph R. , Miller Daniel , Ervin Thomas J. 
Published: February 2007

AbstractTwo patients with squamous cell carcinoma of the head and neck are reported in whom the syndrome of inappropriate antidiuretic hormone (SIADH) secretion occurred transiently during the rapid cytolytic phase of tumor destruction after chemotherapy with cis‐platinum diamminedi‐chloride and bleomycin. Immunoperoxidase staining for ADH of the original biopsy specimens from both patients was negative. Possible mechanisms for and the implications of the production of SIADH in this setting are discussed.
An assessment of the value of triple endoscopy in the evaluation of head and neck cancer patients
Authors: Schuller David E. , Fritsch Michael H. 
Published: February 2007

AbstractThe purpose of this study was to evaluate the role of triple endoscopy in the routine diagnostic evaluation of head and neck cancer patients to (1) ascertain the accuracy and safety of this approach in identifying multiple neoplasms and (2) determine if such an approach is justifiable rather than relying on radiographic examinations coupled with the routine head and neck exam including indirect laryngoscopy. in this series, The incidence of second malignancies was found to be 11.3%, consistent with other reports in the medical literature. There were no complications noted as a result of triple endoscopy. There were no instances where the second malignancy was not diagnosed prior to triple endoscopy with either the physical exam or routine roentgenograms. There were no incidences where the treatment program of the primary tumor was altered by the information obtained at triple endoscopy. The results of this single institutional study suggest that triple endoscopy need not be a routine component of the diagnostic evaluation of every patient with head and neck cancer. However, every patient should probably have a thorough physical examination coupled with chest and esophageal roentgenograms to search for a simultaneous secondary neoplasm.
Retroperitoneal sarcomas: The yale experience and a review of the literature
Authors: Harrison Louis B. , Gutierrez Enrique , Fischer James J. 
Published: February 2007

AbstractBetween 1964 and 1978, 23 patients were referred for radiation therapy for retroperitoneal sarcoma. Three patients had complete excision and negative resection margins and all survived for 5 years without recurrent disease. One patient had complete resection but positive margins, but had a local recurrence 3 1/2 years after radiation. One patient had partial excision with gross residual, and this patient survived only 17 months after an incomplete radiation treatment schedule. Ten cases had biopsy only and were then referred. We found that there were only four cases that survived longer than 1 year, and their average dose of radiation was 4,400 rads, as compared to only 2,691 rads for the remaining six. We conclude that for incompletely resected or only biopsied retroperitoneal sarcoma, doses of 4,000‐5,000 rads should be given and then a re‐evaluation for complete resection should be done with CT scan and re‐exploration. For completely resected cases, we feel that postoperative radiation adds to the local control. We have reviewed the literature and presented the data in support of our conclusions.
Papillary epithelial neoplasm of the pancreas in the pediatric population
Authors: Reed Donald N. , Turcotte Jeremiah G. 
Published: February 2007

AbstractCancer of the pancreas is an uncommon entity in the pediatric population and there have been only three reports of what may be termed papillary epithelial neoplasm of the pancreas. We recently treated a young patient with this tumor, and comparison with the previously reported cases suggests a specific histologic and clinical picture, preferred treatment approach, and likely prognosis.
Radiotherapy for prostate carcinoma
Authors: Leonard Kevin , Stryker John A. 
Published: February 2007

AbstractThe charts of 96 patients who received radiotherapy at The M. S. Hershey Medical Center for their prostatic carcinoma were reviewed. The 4‐year NED (no evidence of disease) survival rates for patients receiving between 6500 and 7000 rad of external beam radiation (EBR) were 92, 78, 56, ant 50% for stages A, B, C, and D1, respectively. The 4‐year NED survival rate for stage B patients was 90% for those receiving approximately 6500 rad of EBR, 75% for those receiving approximately 7000 rad of EBR and 71% for those receiving interstitial implants. Bowel or urinary complications occurred in 27% 21 % grade I, 3% grade II, and 3% grade III of those receiving approximately 6500 rad of EBR, 40% (25% grade I 10% grade II, and 5% grade III) of those receiving 7000 rad of EBR, and 0% of those receiving interstitial implants. The effects of stage, grade and treatment type on NED survival and complications are discussed.
Accurate prediction of experimental cancer chemosensitivity using the subrenal capsule xenograft assay
Authors: Bennett James A. , Pilon Vernon A. , Uppal Gurvinder S. , McKneally Martin F. 
Published: February 2007

AbstractThe chemosensitivity of a murine lung carcinoma grown as a xenograft under the kidney capsule of a rat was compared to the chemosensitivity of this tumor grown as a spontaneous metastasis in its syngeneic host. The chemosensitivity of the tumor to intravenously or subcutaneously administered drugs determined in the short‐term xenograft assay accurately predicted the chemosensitivity of this tumor when it was growing as a spontaneous micrometastasis in its syngeneic host, indicating that in both situations the pharmacological determinants of tumor response to anticancer drugs were similar. These results suggest that tumors growing as xenografts under the kidney capsule accurately reflect the responsiveness of these tumors to chemotherapy and support further investigation of the xenograft subrenal capsule assay as a model that may be useful in predicting effective chemotherapy for human tumors.