bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influencing factors of sleep quality in pregnant: a structural equation model approach
Authors: Bahani Mailiman , Zhang Yuxia , Guo Yufeng , Haretebieke Salawati , Wu Di , Zhang Liping 
Published: March 2024

Abstract
Background
To describe the changes in the level of sleep quality during pregnancy among pregnant women in Urumqi; also to construct a structural equation model of the factors influencing the sleep quality of pregnant women, to analyze the path relationship between the influencing factors, and to take reasonable interventions to prevent and reduce the occurrence of sleep disorders among pregnant women.

Methods
986 pregnant women who gave birth in Urumqi Maternal and Child Health Hospital and Urumqi Youai Hospital between August 2021 and May 2023 were selected. The Pittsburgh Sleep Quality Index (PSQI), Self-Rating Anxiety Scale (SAS), and Edinburgh Postpartum Depression Scale (EPDS) were used to assess the sleep, anxiety, and depression of pregnant women, Building a structural equation model based on AMOS 23.0 Tools.

Results
The results of structural equation modeling showed that: basic characteristics, obstetrical characteristics, tocolysis, lifestyle, psychological had a direct effect on the PSQI, with path coefficients of 0.243, 0.106, 0.140, 0.174, 0.658, the corresponding T-values for each path are 4.585, 2.677, 2.578, 2.297, and 9.036. The indirect effect of basic characteristics, obstetric characteristics and lifestyle on PSQI was 0.123, 0.020, 0.027.

Conclusions
The high incidence of sleep disorders in pregnant women and their close association with psychological symptoms in pregnant women should focus on screening and counseling regarding psychological disorders in pregnant women, thus improving the quality of sleep in pregnant women.
Harnessing adenovirus in cancer immunotherapy: evoking cellular immunity and targeting delivery in cell-specific manner
Authors: Zeng Miao , Zhang Wei , Li Yisheng , Yu Li 
Published: March 2024

AbstractRecombinant adenovirus (rAd) regimens, including replication-competent oncolytic adenovirus (OAV) and replication-deficient adenovirus, have been identified as potential cancer therapeutics. OAV presents advantages such as selective replication, oncolytic efficacy, and tumor microenvironment (TME) remodeling. In this perspective, the principles and advancements in developing OAV toolkits are reviewed. The burgeoning rAd may dictate efficacy of conventional cancer therapies as well as cancer immunotherapies, including cancer vaccines, synergy with adoptive cell therapy (ACT), and TME reshaping. Concurrently, we explored the potential of rAd hitchhiking to adoptive immune cells or stem cells, highlighting how this approach facilitates synergistic interactions between rAd and cellular therapeutics at tumor sites. Results from preclinical and clinical trials in which immune and stem cells were infected with rAd have been used to address significant oncological challenges, such as postsurgical residual tumor tissue and metastatic tissue. Briefly, rAd can eradicate tumors through various mechanisms, resulting from tumor immunogenicity, reprogramming of the TME, enhancement of cellular immunity, and effective tumor targeting. In this context, we argue that rAd holds immense potential for enhancing cellular immunity and synergistically improving antitumor effects in combination with novel cancer immunotherapies.
The more we search, the more we find: discovering and expanding the biodiversity in the ring nematode genus Xenocriconemella De Grisse and Loof, 1965 (Nematoda: Criconematidae)
Authors: Archidona-Yuste A. , Clavero-Camacho I. , Ruiz-Cuenca A. N. , Cantalapiedra-Navarrete C. , Liebanas G. , Castillo P. , Palomares-Rius J. E. 
Published: March 2024

AbstractThe ring nematode genus Xenocriconemella De Grisse and Loof, 1965 comprises only one nominal species, Xenocriconemella macrodora (Taylor, 1936) De Grisse and Loof, 1965. The initial objective of the present study was to investigate the morphological–morphometric and molecular diversity of 28 X. macrodora populations in the Iberian Peninsula associated with tree forests (mainly Quercus spp.). However, a detailed integrative taxonomic analysis (morphological–morphometric and molecular data) from each population and analysis of this data using principal component analysis (PCA) for morphometric data (including these 28 populations and other 25 X. macrodora populations around the world) and molecular and phylogenetic species delimitation methods revealed that X. macrodora forms a species complex. This species complex is composed by species that are morphometricly and morphologically similar, but clearly different at the molecular level. Three new species are described applying integrative taxonomy, namely as Xenocriconemella iberica sp. nov., Xenocriconemella paraiberica sp. nov. and Xenocriconemella pradense sp. nov. However, the molecular diversity of this species in USA and Italy confirmed that additional species are likely present in this species complex, and the diversity of this group may be higher than expected. The study of X. macrodora topotypes can clarify the position of this species using molecular markers under an integrative approach.
Efficiency analysis and benchmarking of container ports operating in lower-middle-income countries: a DEA approach
Authors: Danladi Caleb , Tuck Sarah , Tziogkidis Panagiotis , Tang Lijun , Okorie Chukwuneke 
Published: March 2024

AbstractContainer ports play a pivotal role in international trade, facilitating the movement of goods and fostering economic development. While much attention has been given to the efficiency of ports in high-income countries, container ports in lower-middle-income (LMI) countries have received less attention. This paper addresses this research gap by assessing container ports' operational efficiency across diverse LMI countries and determining ways for their efficiency enhancement and management optimization. The cross-sectional data for the year 2012 was collected for 53 container ports in LMI countries. This research utilizes data envelopment analysis, which offers the advantage of considering multiple inputs and outputs. The results show that the overall technical inefficiencies of LMI countries' container ports are mainly due to pure technical inefficiency rather than scale inefficiencies, and the most efficient ports have a combination of large and hub ports. They also reveal that larger ports (as measured by throughput) are not necessarily more efficient than ports with a small production scale. The results of this research can provide government authorities, port authorities, terminal operators, and investors with valuable insights into resource allocation, competitive advantage, and optimization of operating performance.
The impact of the belt and road initiative on the Suez Canal cargo trade
Authors: Rakha Anas , El‑Aasar Khadiga 
Published: March 2024

AbstractThe Suez Canal (SC) serves as the shortest maritime transport route from east to west. In the absence of the SC, global trade and transportation costs would increase substantially, impeding the expansion potential of the global economy. The Belt and Road Initiative (BRI) is a key component of China's future international trading network, with significant implications for global seaborne trade. The BRI's two primary pillars are the Maritime Silk Road (MSR) and the Silk Road Economic Belt, both of which have significant infrastructural investments. The MSR connects China to various regions in Asia, Africa, and Europe via the SC, thereby serving as a significant maritime trade route on a global scale, particularly between Europe and China. This is due to the SC's distinctive positioning on the MSR. Consequently, studying the significance of BRI for the SC cargo trade is crucial. This study uses annual data from 1990 to 2022 to examine this dynamic relationship. To account for the interaction effect of the variables, we use the vector autoregressive model and the impulse response function. Model results show that China's seaborne trade will increase SC trade by 23%, and China's BRI investment projects are anticipated to have a 5% significant impact on SC cargo trade and will continue to grow in the medium and long run. According to these findings, the SC has to continue to adopt more flexible pricing and marketing strategies to encourage and attract more customers. As a result, the SC could become a global logistics center and transform from a trade gateway to a global hub if it develops more value-added activities in its adjacent areas and attracts substantial Chinese investments.
In-target production of [11C]CH4 from a nitrogen/hydrogen gas target as a function of beam current, irradiation time, and target temperature
Authors: Helin Semi , Rajander Johan , Aromaa Jussi , Arponen Eveliina , Helin Jatta S. , Solin Olof 
Published: March 2024

Abstract
Background
Production of [11C]CH4 from gas targets is notorious for weak performance with respect to yield, especially when using high beam currents. Post-target conversion of [11C]CO2 to [11C]CH4 is a widely used roundabout method in 11C-radiochemistry, but the added complexity increase the challenge to control carrier carbon. Thus in-target-produced [11C]CH4 is superior with respect to molar activity. We studied the in-target production of [11C]CO2 and [11C]CH4 from nitrogen gas targets as a function of beam current, irradiation time, and target temperature.

Results
[11C]CO2 production was practically unchanged across the range of varied parameters, but the [11C]CH4 yield, presented in terms of saturation yield YSAT(11CH4), had a negative correlation with beam current and a positive correlation with target chamber temperature. A formulated model equation indicates behavior where the [11C]CH4 formation follows a parabolic graph as a function of beam current. The negative square term, i.e., the yield loss, is postulated to arise from Haber–Bosch-like NH3 formation: N2 + 3H2 → 2NH3. The studied conditions suggest that the NH3 (liq.) would be condensed on the target chamber walls, thus depleting the hydrogen reserve needed for the conversion of nascent 11C to [11C]CH4.

Conclusions
[11C]CH4 production can be improved by increasing the target chamber temperature, which is presented in a mathematical formula. Our observations have implications for targetry design (geometry, gas volume and composition, pressure) and irradiation conditions, providing specific knowledge to enhance [11C]CH4 production at high beam currents. Increased [11C]CH4 radioactivity is an obvious benefit in radiosynthesis in terms of product yield and molar radioactivity.
Association between thoracic density and area with COVID-19 outcomes
Authors: Ahmadzadeh Nanva Amirhasan , Haghighi-Morad Maryam , Taheri Mahbobeh , Nosrati Maryam 
Published: March 2024

Abstract
Background
The relationship between sarcopenia and the consequences of COVID-19 is not yet fully understood. It is noteworthy that information about muscle status can be easily retrieved by segmenting specific regions of skeletal muscles on CT scans. Our aim in this study was to investigate the relationship between sarcopenia and the consequences of COVID-19.

Methods
In this analytical cross-sectional study, 338 patients with COVID-19 who had a positive PCR test for COVID-19 and underwent chest CT scan in Loghman-e-Hakim Hospital from July to September 2021 were evaluated. Age, sex, background diseases, mechanical ventilation, duration of hospitalization, as well as lab tests, ICU admission and mortality were extracted from patient records. The severity of COVID-19 disease and the area and density of paraspinal muscles at the level of T5 and T12 vertebrae were evaluated through chest CT scans.

Results
Length of stay had significant relationship with T5 density (1.15 (< 0.001)) and T12 density (1.24 (< 0.001). The mean of T12 area (3.35 (P = 0.005) and T12 density 4.59 (P = 0.012) were significantly lower in ICU admitted. There was a significant relationship between mortality and age, cardiovascular disorders, COPD, underlying disease, length of stay, WBC and lymphocyte levels, as well as the severity of the disease.

Conclusions
Based on the results of this study, we can infer that the use of CT scan in patients with COVID-19 and the determination of muscle area and density can predict the consequences of COVID-19, such as a longer duration of hospitalization, the need for admission to the ICU, and mortality.
Estimation of effective doses to whole-bodies and hands of facilitating staff from radioiodine-131 ablation therapy patients
Authors: Al-Esaei Abdulrahman Mofreh , Saleh Emran Eisa , El Maghraby Sharief , Elsayed Tamer Mahmoud , Kany Amr Mohamed Ismail 
Published: March 2024

Abstract
Background
Workers in the field of radiation therapy are exposed to radiation hazards, and it is necessary to take precautions to limit the radiation dose to nursing staff and physicists.

Objective
To evaluate the external dose rate (EDR), effective whole-body dose (EHD) and hand equivalent dose (HED) for facilitating staff from radioiodine-131 (RAI-131) ablation therapy patients.

Methods
One hundred and eighty patients were selected from two radiotherapy centers in Cairo, Egypt in this study and divided into three groups, Group-A, Group-B and Group-C according to administered activities of (RAI-131) of 3700 MBq, 4440 MBq and 5550 MBq for ablation therapy patients respectively. The EDR, EHD and HED were measured using electronic dosimeters.

Results
The average EDR were 79.1 ± 12.1, 22.7 ± 8.5, 7.0 ± 4.0, 2.9 ± 1.3 and 1.9 ± .9.0 μSv h−1 for group-A, and about 87.8 ± 14.0, 25.6 ± 9.0, 8.1 ± 5.0, 3.4 ± 2.0 and 2.4 ± 1.0 μSv h−1 for group-B and were 93.5 ± 17.0, 31.6 ± 11.0, 10.1 ± 7.0, 4.7 ± 3.0 and 3.4 ± 1.5 μSv h−1 for group-C at 2 h, second, third, fourth and fifth days, respectively after administration of RAI-131. The average annual effective doses were 2.76 ± 0.09 and 1.55 ± 0.05 mSv at center 1, and were about 2.96 ± 0.09 and 1.71 ± 0.06 mSv at center 2 for physicists and nurses, respectively.

Conclusion
The EDR as well as the EHD and the HED received by radiation therapy workers up to the fifth day of administered activity RAI-131 were within the limits of values recommended by the International Commission on Radiation Protection (ICRP).
In vivo regeneration efficiency of enset (
Ensete ventricosum
(Welw.) Cheesman) as affected by age of parent plant and corm proportion
Authors: Bora Fikadu , Haile Bewuketu 
Published: March 2024

Abstract

In cultivation,
E. ventricosum
is propagated clonally with adventitious buds sprouting from callus formed on the cut surfaces of the corm. The present study was conducted to enhance the efficiency of this indigenous enset propagation technique by identifying the optimum age of parent plants and corm types for maximum shoot production. This study was conducted using corms in the range of 12–18, 20–28, 29–38, and 40–50 cm diameter, corresponding to four age classes (1, 2, 3 & 4 years old) and three corm treatments (whole, half and quarter) were arranged in 3 × 4 factorial combination and layout in randomized complete block design with three replications. The statistical program SAS Version 9.3 was used to examine the data. The result of the study showed that all of the parameters considered were significantly affected by the treatments or their interaction effects. The number of shoots produced per corm was significantly (p < 0.01) affected by the interaction of the age of the parent plant and corm treatment. The average number of shoots produced per corm was between 43 and 443 shoots per com. The highest shoot numbers (443 shoots per corm) were recorded on the 3-year plant using quarter corm; whereas the lowest number of shoots (43 shoots per corm) was obtained from whole corms of the 1-year plant. In general, the results of the study showed that the use of quartered corms of 3-year-old parent plants appears to be the efficient technique to regenerate enset in vivo.
Intercropping and environmental seasonality modulate the physiology and growth of
Hancornia speciosa
(Gomes)
Authors: Alves Estenio Moreira , Silva Fabiano Guimarães , Avila Roniel Geraldo , Lourenço Lucas Loram , de Oliveira Thales Caetano , Custódio Aldo Max , Rosa Márcio , Pennacchi João Paulo , do Prado Paim Tiago 
Published: March 2024

Abstract

Background

The recovery process of degraded areas with the implantation of orchards of native species is still little known. Thus, we intend to evaluate the physiological performance of
Hancornia speciosa
during different seasons of the year, cultivated in full sun and in intercropping for recovery of degraded areas.

Methods

Intercropping with
Syagrus oleracea
(double intercropping); with annual crops (double intercropping); and with
S. oleracea
and annual crops (triple intercropping) were completed over two years at the beginning of each season. Crops (experimental plots) were planted using a Nelder wheel design.

Results

Over the two years,
H. speciosa
was observed to experience seasonal regulatory changes, some of which were mitigated by the intercropping. The cultivation arrangement influenced the physiology and consequently the growth of
H. speciosa
.

Conclusions

It is concluded that the double intercropping benefits the growth of
H. speciosa
during the formation of the orchard, and the triple intercropping does not affect growth in relation to full sun. It is recommended the implantation of orchards of
H. speciosa
in recovery areas through intercropping.
Preparation and interaction mechanism analysis of single-chain fragment variables against phenylethanolamine A
Authors: Li Long , Hou Ren , Li Huaming , Han Shiyun , Liang Jixiang , Si Yu , Peng Dapeng 
Published: March 2024

AbstractThis is the first report on the screening, expression, and recognition mechanism analysis of single-chain fragment variable (scFv) against phenylethanolamine A (PEAA), a newly emerged β-adrenergic agonist illegally used as a feed additive for growth promotion. The PEAA-specific scFv scFv, called scFv-32, was screened from hybridoma cell lines by phage display and was found to be optimally expressed in the E. coli system. The ic-ELISA results revealed an IC50 value of 10.34 μg/L for scFv-32 and no cross-reactivity with other β-adrenergic agonists. Homology modeling and molecular docking revealed the key binding sites VAL178, TYP228, and ASP229. One hydrogen bond, two pi-sigma bonds, and one pi-pi bond maintain the formation of the antibody‒drug complex. Alanine scanning mutagenesis of the three predicted key binding sites showed that the mutants completely lost their recognition activity, which confirmed the accuracy of the theoretical analysis. These results are valuable for the preparation of scFvs and the analysis of the molecular recognition mechanism of antigen-antibodies.
Graphical abstract
Development of a lateral flow immunochromatography assay for the detection of fluoroacetamide in blood samples
Authors: Li Qiang , Yang Ling , Duan Changfei , Wang Xiaonan , Yu Xuezhi 
Published: March 2024

AbstractFluoroacetamide (FAM) has been employed as a rodenticide for an extended duration, leading to a multitude of incidents involving human ingestion poisoning. Currently, FAMs have been prohibited by nations globally; however, there are still instances of their illegal usage. Conventional instrument methods are characterized by their time-consuming nature and complex operational procedures, rendering them inadequate for meeting urgent diagnostic needs in patients with acute FAM poisoning. Therefore, there is an immediate need to develop a prompt, user-friendly, and precise immunoassay method for the diagnosis of acute poisoning induced by FAM. A lateral flow immunochromatography assay (LFIA) was developed in this study for the visual detection of FAMs in blood samples, representing the first report of such an approach. The method exhibited a cut-off value of 0.5 mg/mL under the optimized conditions, enabling the entire FAM detection process in blood samples to be completed within a mere 8 min without any pretreatment requirements. Notably, the results were easily discernible by visual inspection alone. These results indicate that the developed LFIA holds great promise as a convenient and rapid diagnostic tool for FAM poisoning diagnosis, thereby offering valuable support for subsequent treatment strategies.
New Reference Values for Thyroid Volume by Ultrasound in German Children and Adolescents From a Population-Based Study
Authors: Hirtz Raphael , Thamm Roma , Kuhnert Ronny , Liesenkötter Klaus-Peter , Thamm Michael , Grasemann Corinna 
Published: March 2024

Abstract

Context
Reliable reference values for thyroid ultrasound measurements are essential to effectively guide individual diagnostics and direct population-level health care measures, such as iodine fortification programs. However, the latest reference values for total thyroid volume (Tvol) provided by the World Health Organization (WHO) in 2004 only apply to the 6- to 12-year-old age group and are limited to countries with a long history of iodine sufficiency, which does not reflect the situation in most European countries, including Germany.

Objective
This study aims to derive up-to-date thyroid volume ultrasound reference values in German children and adolescents.

Methods
Data from the baseline assessment of a nationwide study in German children and adolescents (KiGGS) conducted between 2003 and 2006 were used to determine sex-specific reference values for Tvol in thyroid-healthy participants aged 6 to 17 years by age and body surface area according to the lambda-mu-sigma method.

Results
Data from 5559 participants were available for reference chart construction (2509 girls [45.1%]). On average, the 97th percentile is 33.4% and 28.5% higher than the corresponding WHO reference values for boys and girls, respectively. These findings are consistent with most other studies in German and European children and adolescents at a similar time of investigation. Notably, the sample used for this study was iodine-sufficient according to WHO criteria.

Conclusion
The reference values provided by the WHO are overly conservative for this population and could potentially apply to other European countries with a similar history of iodine supply.
Diuretic Use and Serum Phosphate: Rotterdam Study and UK Biobank
Authors: Bosman Ariadne , Campos-Obando Natalia , de Keyser Catherine E , Stricker Bruno H , Zillikens M Carola 
Published: March 2024

Abstract

Purpose
Hypophosphatemia (serum phosphate &lt; 0.80 mmol/L) leads to musculoskeletal complaints. The most common drugs linked to hypophosphatemia are thiazide and loop diuretics, but studies in the general population are lacking. Our aim was to study associations between diuretic use and serum phosphate in the Rotterdam Study (RS), a population-based cohort study, with replication in UK Biobank (UKBB).

Methods
Associations between thiazide and loop diuretic use and serum phosphate and odds of hypophosphatemia were analyzed with cross-sectional multivariate linear and logistic regression in participants without chronic kidney disease in the RS and UKBB. Analyses were adjusted for age, sex, and body mass index (BMI) and pooled in 3 RS cohorts with further adjustment for cohort and serum potassium, which was not available in UKBB.

Results
Thiazide diuretics were associated with lower serum phosphate in both sexes. This association lost significance in RS females after adjustment for BMI and in males after adjustment for serum potassium. Thiazide diuretics increased odds of hypophosphatemia in females in both cohorts and in males in UKBB only. Loop diuretics were associated with lower serum phosphate in females but not males. Adjustment for BMI attenuated these associations. Associations between loop diuretics and increased odds of hypophosphatemia in females lost significance after BMI adjustment.

Conclusion
Thiazides, but not loop diuretics, and increased BMI and decreased serum potassium should be considered as contributing factors in subjects with hypophosphatemia. Further studies are needed to replicate the findings and elucidate the potential role of hypokalemia as a mediator of this effect.