bluuebunny/crossref_metadata_2025_split huggingface dataset:
New heterocyclic ring systems. XII. Synthesis of [1,4]thiazinocarbazoles
Authors: Brunelli C. , Fravolini A. , Grandolini G. , Strappaghetti G. 
Published: March 2009

AbstractFive [1,4]thiazinocarbazoles have been synthesized from 6‐, 7‐ and 8‐amino‐2H[1,4]benzo‐thiazin‐3(4H)ones by the Jaap‐Klingemann reaction with 2‐hydroxymethylenecyclohexanone followed by Fischer indolisation of the resulting hydrazones. The structures of the hitherto unknown ring systems have been confirmed by pmr spectral data.
Reactions with heterocyclic amidines. VI. Synthesis and chemistry of pyrazol‐5‐yl, and 1,2,4‐triazol‐5‐ylhydrazonyl chlorides
Authors: Elnagdi Mohamed Hilmy , Elmoghayer Mohamed Riffaat Hamza , Elfaham Hassan Attia , Sallam Mohamed Mohamed , Alnima Hikmat Hussein 
Published: March 2009

AbstractThe 4‐bromo‐3‐phenylpyrazol‐5‐ylhydrazonyl chlorides (Ia,b) and 1,2,4‐triazol‐5‐ylhydrazonyl chlorides (IIa,b) were prepared via coupling of diazotized 4‐bromo‐3‐phenyl‐5‐aminopyrazole (III) and 5‐amino‐1,2,4‐triazole (IV) with α‐chloro derivatives of acetylacetone and of ethyl aceto‐acetate. Compounds Ia and IIa,b were utilised for the synthesis of several new heterocyclic derivatives.
Chiroptical properties of some N‐5(6)benzofuroxanoyl‐L‐α‐amino acids and esters
Authors: El‐Abadelah Mustafa M. , Anani Ali A. , Khan Zahida H. , Hassan Ata M. 
Published: March 2009

AbstractThe CD spectra of a series of N‐5(6)benzofuroxanoyl‐L‐α‐amino acids and esters reveal, in ethanol and acetonitrile, cotton effect (CE) bands around 365, 320, 265 and 223 nm. It was found that the signs of the CE maxima, located at longest and shortest wavelengths, were both positive for the L ‐aliphatic series, whereas these bands display sign inversion in the CD spectra of the L ‐aromatic counterparts. This chiroptical behaviour might be attributed to conformational differences. Nmr spectral data give support to this assumption. Mass spectral fragmentations of these compounds are discussed.
cis‐ and trans‐N‐nitroso‐2,4‐diphenylazetidines
Authors: Powell Burwell F. , Reichenthal Jules , Overberger C. G. , Anselme J.‐P. 
Published: March 2009

AbstractThe synthesis of cis‐ and trans‐2,4‐diphenylazetidines as well as that of their N‐nitroso derivatives is described. The “abnormal” reduction of the N‐nitrosamines gives a cis‐trans mixture of the expected 1,2‐diphenylcyclopropanes. However, no stereochemical correlations could be made owing to the base‐induced isomerization of the starting N‐nitrosamines during the course of the reaction.
Synthese de nouvelles 1H,3H pyrido[2,3‐d] pyrimidinediones‐2,4
Authors: Brunel Suzanne , Montginoul Claude , Torreilles Eliane , Giral Louis 
Published: March 2009

AbstractDans cet article les auteurs décrivent la synthèse et les propriétés physico‐chimiques de nouvelles pyrido[2,3‐d]pyrimidinediones‐2,4 mono ou disubstituées.
Antibakterielle wirkstoffe. IV. Die nitrosubstitution im system der 5‐amino‐4‐cyanpyrazole
Authors: Kreutzberger Alfred , Burgwitz Klemens 
Published: March 2009

AbstractDie Umsetzung von Ethoxymethylenmalononitril (1) mit Nitrophenylhydrazinen (2a‐d) führt zu 5‐Amino‐4‐cyan‐1‐(nitrophenyl)pyrazolen (4a‐d), unter denen besonders 4d durch antibakterielle Wirksamkeit auffällt.
Chemistry of sulfonyl isocyanates and sulfonyl isothiocyanates. IX. Routes to substituted oxazolidin‐2‐ones and oxazolidine‐2‐thiones
Authors: Mcfarland J. W. , Hayes C. E. , Blair E. B. , Stuhlmacher K. R. 
Published: March 2009

Abstract4‐Chlorobenzenesulfonyl isocyanate (I) reacted with 2‐chloroethanol and 1‐chloro‐2‐propanol to give, respectively, 2‐chloroethyl 4‐chlorobenzenesulfonyl carbamate (III) and 1‐chloro‐2‐propyl 4‐chlorobenzenesulfonyl carbamate (VI). The carbamates III and VI cyclized under the influence of pyridine to afford, respectively, 3‐(4‐chlorobenzenesulfonyl)oxazolidin‐2‐one (IV) and 3‐(4‐chlorobenzenesulfonyl)‐5‐methyloxazolidin‐2‐one (VII). The oxazolidin‐2‐ones were stable toward hydrochloric acid but hydrolyzed in 2M sodium hydroxide solution to N‐(2‐hydroxyethyl)‐4‐chlorobenzenesulfonamide (V) and N‐(2‐hydroxy‐1‐propyl)‐4‐chlorobenzene‐sulfonamide (VIII), respectively. 4‐Toluenesulfonyl isothiocyanate (II) reacted with 2‐chloroethanol to give 2‐chloroethyl 4‐chlorobenzenesulfonyl thiocarbamate (IX), which was converted by pyridine to 3‐(4‐toluenesulfonyl)oxazolidine‐2‐thione (X).
4‐Substituted‐3,4‐dihydro‐3‐methyl‐2H‐1,3‐benzoxazin‐2‐ones. III (2,3). Solvolytic‐reductive transformation of 4‐(2‐keto)‐benzoxazin‐2‐ones into oxazin‐2‐ones
Authors: Bobowski George , Shavel John 
Published: March 2009

AbstractA series of 4‐(2‐keto‐substituted)‐3,4‐dihydro‐3‐methyl‐2H‐1,3‐benzoxazin‐2‐ones 1 (Table I) was synthesized by condensation of 3‐alkyl‐3,4‐dihydro‐4‐hydroxy‐2H‐1,3‐benzoxazin‐2‐ones 4 with ketones 5 having active alpha hydrogens. In the presence of alcoholic potassium borohydride, compounds 1 underwent reductive transacylation to give 1,3‐oxazin‐2‐one derivatives 3 (Table III, a,b,c). When the other side of the ketone possessed substituents other than hydrogen, there were always also normal reduction products, i.e., secondary alcohols 2 (Table II) in addition to 3.
Studies on tertiary amine oxides. LXVII . Reactions of aromatic N‐oxides with 3‐arylrhodanines in the presence of acetic anhydride
Authors: Yousif Mohammed M. , Saeki S. , Hamana M. 
Published: March 2009

AbstractQuinoline 1‐oxides 1 readily react with 3‐arylrhodanines 2 in the presence of acetic anhydride to afford 3‐aryl‐5‐(2‐quinolyl)rhodanines 3 in high yields. These products resist hydrolysis under both alkaline and acidic conditions, but is oxidized to quinaldinic acid 1‐oxide 4 with 30% hydrogen peroxide in hot acetic acid. Besides isoquinoline 2‐oxide 5, pyridine 1‐oxide 7a also reacts in the same way to give 3‐aryl‐5‐(2‐pyridyl)rhodanines 8, although the reactivity of γ‐picoline 1‐oxide 7b is considerably lower. Contrary to 3, 3‐phenyl‐5‐(2‐pyridyl)rhodanine 8a is successfully hydrolyzed with boiling 48% hydrobromic acid to 2‐pyridinemethanethiol 10 in 57% yield.
Synthesis, polarography and herbicidal activity of quaternary salts of 2‐(4‐pyridyl)‐1,3,5‐triazines, 5‐(4‐pyridyl)pyrimidine, 2‐(4‐pyridyl)pyrimidine and related compounds
Authors: Fischer Hanspeter , Summers Lindsay A. 
Published: March 2009

Abstract2‐(4‐Pyridyl)‐1,3,5‐triazine, 2‐(4‐pyridyl)‐4‐methyl‐1,3,5‐triazine, 2‐(4‐pyridyl)‐4,6‐dimethyl‐1,3,5‐triazine and 2‐(4‐pyridyl)pyrimidine have been prepared by modification of established triazine and pyrimidine syntheses. These compounds and some of their relatives have been converted to quaternary pyridinium salts. The polarographic reduction potentials of the salts in aqueous solution are pH dependent. The activity of the salts as post‐emergent herbicides is reported.
Imidazo[1,2‐α]pyrimidines and 1,2,4‐triazolo[1,5‐α]pyrimidines: Two new examples of mesoionic xanthine analogs
Authors: Glennon R. A. , Rogers M. E. , El‐Said M. K. 
Published: March 2009

AbstractSeveral derivatives of mesoionic imidazo[1,2‐α]pyrimidine‐5,7‐dione and 1,2,4‐triazolo[1,5‐α]pyrimidine‐5,7‐dione, two new examples of mesoionic xanthine ring systems, were prepared and characterized. These compounds were conveniently prepared by the condensation of bis‐(2,4,6‐trichlorophenyl) malonates with the appropriately substituted alkylaminoimiazole or 1,2,4‐triazole.
Synthèse d'hétérocycles en catalyse par transfert de phase
Authors: Dou Henri J.‐M. , Ludwikow Maria , Hassanaly Parina , Kister Jacky , Metzger Jacques 
Published: March 2009

AbstractDans cette note, nous décrivons brièvement quelques résultats permettant de cerner l'utilisation de la catalyse par transfert de phase dans les réactions d'hétérocyclisation. Des réactifs dihalogénés sont utilisés, les anions engagés dans la substitution provenant soit de dianions ambidents hétérocycliques, soit de l'éthanedithiol.
A novel improved synthesis of 3‐aminopyrazine‐2‐carboxylic acid
Authors: Buckland Paul R. 
Published: March 2009

AbstractA three step synthesis of 3‐aminopyrazine‐2‐carboxylic acid (1) starting from pyrazine‐2,3‐dicarboxylic acid (5) is described. Diacid 5 is converted via the anhydride 6 into the ammonium salt of the half acid amide 7 which on Hofmann rearrangement gives the title compound in 55% overall yield.
Synthesis in the diazasteroid group. XII Syntheses of the 10,17‐diazasteroid and 10‐aza‐17‐thiasteroid systems
Authors: Takahata Hiroki , Hara Misao , Tomiguchi Akira , Yamazaki Takao , Castle Raymond N. 
Published: March 2009

AbstractUpon desulfurization with Raney Ni, the condensed heterocycles 2a,b prepared by cyclization from β‐ketosulfoxides 1a,b gave β‐ketones 3a,b, which were condensed with 2‐carbethoxymethyl‐piperidine 4 to afford the 10,17‐diazasteroid 6 and the 10‐aza‐17‐thiasteroid 7, respectively.
Cinnoline chemistry. XIV. 3‐cyclohexylcinnolines
Authors: Maeba Isamu , Castle Raymond N. 
Published: March 2009

AbstractThe synthesis of 3‐cyclohexyl‐6,7‐dimethoxy‐1H‐4‐cinnolone (4), 4‐chloro‐3‐cyclohexyl‐6,7‐dimethoxycinnoline (5) and 8‐bromo‐3‐cyclohexyl‐6,7‐dimethoxy‐1H‐4‐cinnolone (6) are reported.
Syntheses and reactions of some 4,5‐dihaloimidazole‐2‐carboxylic acid derivatives
Authors: Dirlam John P. , James Richard B. , Shoop Eleanor V. 
Published: March 2009

AbstractThe preparation of 5H,10H‐diimidazo[1,2‐a:1′,2′‐d]pyrazine‐5,10‐dione (2a) and its 2,3,7,8‐tetrabromo‐ and 2,3,7,8‐tetrachloro‐ analogs (2b and 2c, respectively) is reported. These dimers, when allowed to react with various anilines, afford imidazole‐2‐carboxamides (3a‐c).
Synthesis of 2‐chloro‐5‐hydroxynicotinonitrile: The required intermediate in the total synthesis of a hydroxylated metabolite of (S)‐2‐(3‐t‐butylamino‐2‐hydroxypropoxy)‐3‐cyanopyridine
Authors: Ponticello Gerald S. , Engelhardt Edward L. , Freedman Mark B. , Baldwin John J. 
Published: March 2009

AbstractA convenient method for the synthesis of 2‐chloro‐5‐hydroxynicotinonitrile (10) via 5‐amino‐2‐chloro‐3‐methylpyridine (3) is described. Subsequent conversions provided the basic metabolite 2 of (S)‐2‐(3‐t‐butylamino‐2‐hydroxypropoxy)‐3‐cyanopyridine (1). 13C Nmr data is also presented to characterize 2‐chloro‐5‐fluoro‐3‐methylpyridine (5), a by‐product in the Schiemann reaction having unexpected 1H and 19F nmr spectra.
Halogenation of vinyl ketoximes. Synthesis of isoxazoles and preparation and silver ion‐promoted reactions of 4‐halo‐2‐isoxazolines
Authors: Hansen John F. , Kim Yong In , Mccrotty Stephen E. , Strong Scott A. , Zimmer Douglas E. 
Published: March 2009

AbstractReaction of several α,β‐unsaturated ketoximes with N‐bromosuccinimide (NBS) gave isoxazoles, but yields were lower and the reaction less general than a similar transformation using iodine under basic conditions. With β,β‐disubstituted oximes, 4‐halo‐5,5‐disubstituted‐2‐isoxazolines were obtained using NBS, iodine, or N‐chlorosuccinimide. Treatment of the 4‐bromoisoxazo‐lines with silver acetate or silver nitrate caused either elimination with rearrangement to give isoxazoles or substitution at C‐4, depending upon the nature of the substituents at C‐5.
The specificity of reductive dechlorination in the polychloropyridine series. Synthesis of 2,3,5‐trichloro‐ and of 2,3,5,6‐tetrachloropyridine
Authors: Sutter P. , Weis C. D. 
Published: March 2009

AbstractThe high specificity of the reduction system zinc and ammonium salts in dimethyl methylphosphonate as solvent is demonstrated in several reductive dechlorination reactions of polychloropyridines. The reduction of pentachloropyridine with zinc/ammonium chloride system in dimethyl methylphosphonate yielded solely 2,3,5,6‐tetrachloropyridine. Similarly, the reduction of 2,3,4,5‐tetrachloropyridine with zinc and the tetramethylammonium salt of methyl methylphosphonate furnished exclusively 2,3,5‐trichloropyridine. A synthetic procedure for the preparation of the new ammonium salts of methyl methylphosphonate is given.
Reactions of ethyl 2‐benzoyl‐3‐phenylcyclopropanecarboxylate with hydrazines and hydroxylamine
Authors: El‐Kholy Ibrahim El‐Sayed , Fuid‐Alla Hassan Mostafa , Mishrikey Marcos Michael 
Published: March 2009

AbstractWhile the reaction of the cyclopropane ester 1 with hydrazine hydrate or phenylhydrazine led to the formation of diazabicycloheptenones, its reaction with several para‐substituted phenyl‐hydrazines gave the corresponding hydrazones. With hydroxylamine, either oxime or 1,2‐oxazinone is formed.
Nuclear magnetic resonance spectra of psychotherapeutic agents. III.. Stereochemistry of 1‐methyl‐5‐phenyl‐2,3,4,5‐tetrahydro‐1H‐1,5‐benzodiazepine‐2,4‐diones
Authors: Aversa Maria C. , Giannetto Placido , Romeo Giovanni , Ficarra Paola , Vigorita Maria G. 
Published: March 2009

AbstractThe stereochemistry of some 1‐methyl‐5‐phenyl‐2,3,4,5‐tetrahydro‐1H‐1,5‐benzodiazepine‐2,4‐diones was determined by proton magnetic resonance using the paramagnetic shift reagent tris(6,6,7,7,8,8,8‐heptafluoro‐2,2‐dimethyl‐3,5‐octanedionato)europium [Eu(fod)3] two of these compounds, clobazam and triflubazam, are clinically used as psychotherapeutic agents. Several model structures, with intermediate stereochemistry in the range of the possible limit situations of benzocycloheptene, ‐cycloheptadiene or ‐cycloheptatriene type, are considered; LIS (3) are computer simulated on the basis of proton geometric parameters. It was found that at room temperature, these derivatives exist in only one pseudo‐boat cycloheptadiene‐like conformation, showing the 5‐phenyl group directed pseudo‐axially. This conformational preference is interpreted in terms of a balance between the steric requirements of the bulky substituent and electronic repulsion in the ring π‐system.
Neue synthese von 1‐acetyl‐3‐methoxycarbonyl‐β‐carbolin
Authors: Razmilića Iváan , Castillo Mariano , Lóapez Joséa Tomáas 
Published: March 2009

AbstractA new synthetic method to obtain 1‐acetyl‐3‐methoxycarbonyl‐β‐carboline using dl‐tryptophan and acetaldehyde as starting materials is described.
Intramolecular 1,3‐dipolar cycloadditions of aliphatic nitrile oxides
Authors: Garanti Luisa , Zecchi Gaetano 
Published: March 2009

AbstractTreatment of functionalized 1‐chloro‐oximes (3c and 4a,b) with triethylamine originates nitrile oxides (1c and 2a,b) which undergo an intramolecular cycloaddition providing fused‐ring isoxazole derivatives (7c and 8a,b). The latter reaction was not observed for one substrate (2c).
Heterocycles from carbohydrate precursors. Part XIX. The X‐ray crystal structure determination of the reaction product of 4‐(2‐acetoxyethylidene)‐4‐hydroxy‐2,3‐dioxobutyro‐1,4‐lactone‐2‐(p‐bromophenylhydrazone) with methylhydrazine
Authors: Stam C. H. , El Ashry El Sayed , El Kilany Yeldez , Van DerPlas H. C. 
Published: March 2009

AbstractX‐ray crystallographic data show that the product obtained in the reaction of 4‐(2‐acetoxy‐ethylidene)‐4‐hydroxy‐2,3‐dioxobutyro‐1,4‐lactone‐2‐(p‐bromophenylhydrazone) with methyl‐hydrazine is the bicyclic compound 2,6‐dimethyl‐3,4‐dioxo‐2,3,4,6,7,8‐hexahydropyridazino‐[4,3‐c]pyridazine 4‐(p‐bromophenylhydrazone) (10) and not as originally suggested 1‐methyl‐3‐(1‐methylpyrazolin‐3‐yl)‐4,5‐pyrazoledione 4‐(p‐bromophenylhydrazone) (8).
Pyrrolo[1,2‐d]triazines‐1,2,4. II. Etude des pyrrolo[1,2‐d]triazinones‐1 et ‐4
Authors: Lancelot Jean‐Charles , Maume Daniel , Robba Max 
Published: March 2009

AbstractLa synthèse des dihydro‐1,2 oxo‐1 pyrrolo[1,2‐d]triazines‐1,2,4 2 est effectuée soit par transposition en milieu alcalin de pyrrolyl‐2 oxadiazoles, soit par cyclisation de N‐éthoxyméthylidène‐hydrazides pyrroliques. La dihydro‐3,4 oxo‐4 pyrrolo[1,2‐d]triazine‐1,2,4 5a est accessible par cyclisation en milieu alcalin de la N‐carbéthoxyhydrazone du formyl‐2 pyrrole. Les réactions de substitution électrophile des pyrrolotriazinones‐1 et ‐4 sont réalisables soit au niveau de l'azote lactamique avec des agents électrophiles tels que le sulfate diméthylique, le chlorure de benzyle ou l'acide monochloracétique, soit au niveau du cycle pyrrolique avec le brome ou l'acide nitrique. Les structures des dérivés obtenus sont établies par rmn 1H.
Two anomalous cyclizations in the dibenz[b,f][1,4]oxazepine series
Authors: Mckenzie Thomas C. 
Published: March 2009

AbstractThe cyclization of 3,5′‐dichloro‐2′‐phenoxypropionanilide (2) to a trimeric cyclohexane 4 and of 4‐bromo‐5′‐chloro‐2′‐phenoxybutyranilide (1) to a tetracyclic pyrrolooxazepine 5 is reported.
Quinazolinone derivatives. Kinetics of the reaction of 2‐chloromethyl‐3‐hydroxy‐4‐(3H)quinazolinone with nucleophiles
Authors: Fernandez Beatriz M. , Schapira Celia B. , Lamdan Samuel 
Published: March 2009

AbstractReaction of 2‐Chloromethyl‐3‐hydroxy‐4(3H)quinazolinone (1) with aliphatic amines and hydroxide follows two different routes affording substituted methyl quinazolinones and a dimer 2 derived from 1. The former were formed by SN2 reactions while the latter was formed by an inter‐molecular nucleophilic displacement. Second‐order and third‐order rate constants, respectively, were determined, and the kinetic factors influencing both parallel reactions were analysed.
Action des isocyanates sur les benzisothiazol‐2,1 ones‐3 (1H) et sur les thiadiazol‐1,2,4 ones‐5: Un nouveau réarrangement avec extrusion de l'atome de soufre
Authors: Perronnet Jacques , Taliani Laurent 
Published: March 2009

AbstractL'action des isocyanates sur les benzisothiaxol‐2,1 ones‐3 (1H) et sur les thiadiazol‐1,2,4 ones‐5 a été étudiée. En présence de quantité stoechiométrique de base organique elle conduit, dans les deux cas, à l'incorporation de deux atomes de l'isocyanate dans l'hétérocycle, avec extrusion simultanée de l'atome de soufre.
Synthesis and spectroscopic studies of some quinolylmethylphosphonates
Authors: Jagodić V. , Tušek‐Božić L. J. , Božić B. , Herak M. J. 
Published: March 2009

AbstractMonoethyl esters of 2‐quinolylmethylphosphonic acid (3) and 8‐quinolylmethylphosphonic acid (6) have been prepared. The corresponding diethyl esters 1 and 4, and sodium salts of monoesters 2 and 5, respectively, have also been isolated. The properties of the monoethyl esters of 8‐ and 2‐quinolylmethylphosphonic acid are very different. While the former was isolated as the hydrochloride, the latter did not form such a salt. Molecular weight determination indicated a dimeric structure of the monoester 3, and spectroscopic measurements confirmed the association presumably owing to the hydrogen bonding between the PO and P‐OH groups.
Polycondensed nitrogen heterocycles. IX. 5,6‐dihydro‐7H‐pyrrolo[1,2‐d][1,4]benzodiazepin‐6‐one
Authors: Dattolo Gaetano , Cirrincione Girolamo , Aiello Enrico 
Published: March 2009

AbstractThe reaction of amino derivative I with bromoacetyl bromide led to the formation of a complex mixture from which, in addition to the title compound, which was formed in low yield, compounds III, IV and VI were separated. Pyrrolo[1,2‐d][1,4]benzodiazepine V was obtained in 85% yield when the bromoamide III was treated with an equimolar amount of potassium t‐butoxide.
The syntheses of ethoxycarbonyl‐1,3‐dioxoles and oxazoles from the copper catalyzed thermolysis of ethyl diazopyruvate in the presence of ketones, aldehydes and nitriles
Authors: Alonso Miguel E. , Jano Patricia 
Published: March 2009

AbstractThe copper salt‐catalyzed interaction of ethyl diazopyruvate with ketones, aldehydes and nitriles was examined. A variety of 1,3‐dioxoles and oxazoles was obtained in moderate yield. The formation of enol ethers, epoxides, carbon‐carbon insertion products, aziridines, and azetidines, typical products of carbene reactions with carbon‐heteroatom multiple bonds, was not observed. Evidence for the operation of a 1,3‐dipolar cycloaddition reaction is presented.
Heterocycles from ylides. Part VIII Reactivity of 2‐arylmethylenebenzofuran‐3‐ones with stabilized sulphur ylides
Authors: Dalla Croce Piero , De Michele Anna 
Published: March 2009

Abstract2‐Arylmethylenebenzofuran‐3‐ones react with carbonyl stabilized sulphur ylides yielding spiro‐[cyclopropane‐1,2′‐benzofuran‐3′‐ones], whose structure and stereochemistry were assigned on the basis of spectroscopic data and chemical behaviour.
Studies on pyridazine derivatives. IV Mesylation reaction of pyridazinylpyrazoles
Authors: Mátyus Péter , Szilágyi Géza , Kasztreiner Endre , Sohár PÁL 
Published: March 2009

AbstractOn mesylation, 1‐pyridazinylpyrazoles (1), give, depending on the substituents and reaction conditions, O‐mesylpyrazoles (2) and O‐mesyl‐4‐N‐mesyl‐1,4‐dihydro‐4‐pyridyl‐pyrazole derivatives (3). The structures of these compounds were confirmed by ir and 1H nmr spectral data.
Investigation of the reaction products of 5‐amino‐1,3‐disubstituted‐pyrazoles with aromatic aldehydes. synthesis of new fluorinated 1,3,4‐trisubstituted‐4H‐pyrazolo[3,4‐e][1,4]thiazepin‐7‐ones
Authors: Joshi Krishna C. , Pathak Vijai N. , Garg Urmila 
Published: March 2009

AbstractThe condensation products of 5‐amino‐1,3‐disubstituted‐pyrazoles with aromatic aldehydes were identified as 2,4‐dihydro‐2,5‐diphenyl‐4‐(phenylmethylene)‐3H‐pyrazol‐5‐imine derivatives Treatment of these products with mercaptoacetic acid gave new fluorine containing 1H‐pyrazolo[3,4‐e][1,4]thiazepin‐7‐ones.
Adducts of 2‐aminothiophenol with acetylenic nitriles or esters and their conversion into benzothiazoles and/or 1,4‐benzothiazines
Authors: Liso Gaetano , Trapani Giuseppe , Berardi Vincenza , Latrofa Andrea , Marchini Paolo 
Published: March 2009

AbstractThe reaction between 2‐aminothiophenol 1 and acetylenic nitriles or esters 2a‐d leads to the vinyl thio‐ethers 3a‐d. The conversion of 3 into benzothiazoles 8 and/or 1,4‐benzothiazines 9, in boiling dimethyl sulfoxide, has been achieved. A possible pathway involving benzothiazolines 5 as key intermediates is suggested.
Electron impact mass spectrometry of 3‐methyl‐4‐benzylideneamine‐5‐styrylisoxazoles. II
Authors: Martinez R. , Cortés E. 
Published: March 2009

AbstractThe mass spectra of a series of substituted 3‐methyl‐4‐benzylideneamine‐5‐styrylisoxazoles are reported and discussed. The spectra of these isoxazoles show a characteristic fragmentation pattern different from the 5‐styryl‐4‐nitroisoxazoles. Perhaps this is due to the presence of the Schiff base at position 4.
Synthesis and spectroscopic studies of some new substituted 6H‐indolo[2,3‐b]quinoxalines
Authors: Sarkis George Y. , Al‐Badri Hashim T. 
Published: March 2009

AbstractSix substituted 6H‐indolo[2,3‐b]quinoxalines were synthesized by the interaction o‐phenyl‐enediamine with substituted isatins. The uv, ir and nmr spectral data for the compounds synthesized are presented and discussed.
1,2,4‐Triazines. 3. halogen‐sulfur exchange in the preparation of 5,6‐disubstituted‐1,2,4‐triazines
Authors: Neumann R. E. , Lovelette Charles A. 
Published: March 2009

AbstractThe preparation and displacement reactions of 3‐amino‐5,6‐bismethylthio‐1,2,4‐triazine (3) are described.
Synthesis of 9‐substituted‐1,4,5,8‐tetraazaphenanthrenes
Authors: Nasielski‐Hinkens Raymonde , Benedek‐Vamos Marie , Maetens Daniel 
Published: March 2009

AbstractThe synthesis of 9‐substituted‐1,4,5,8‐tetraazaphenanthrenes was undertaken in the course of a study aimed at the preparation of organometallic complexing agents.
The selective preparation of 1,4‐diaryl‐6‐methyl‐ and 1,6‐diaryl‐4‐methyl‐2‐(1H)pyrimidinones
Authors: Kashima Choji , Katoh Akira 
Published: March 2009

AbstractN‐Phenylurea reacted with benzoylacetone derivatives (I) to give 1,4‐diaryl‐6‐methyl‐2‐(1H)pyrimidinones (II) in addition to low yields of 1,6‐diaryl‐4‐methyl‐2‐(1H)pyrimidinones (IV), while N‐phenylthiourea afforded only 1,6‐diaryl‐4‐methyl‐2‐(1H)pyrimidinethiones (III) in good yields. Further 1,6‐diaryl‐4‐methyl‐2‐(1H)‐ pyrimidinethiones (III) were successfully converted in satisfactory yields into the corresponding 2‐(1H)‐pyrimidinones (IV) by the treatment with methyl iodide in the presence of sodium methoxide in methanol at room temperature.