bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mucinous cystic tumor of the pancreas: An analysis of fna characteristics with an emphasis on the spectrum of malignancy associated features
Authors: Dodd Leslie G. , Farrell T. A. , Layfield Lester J. 
Published: February 2007

AbstractPreviously, pancreatic mucinous cystic tumors were classified as either benign (cystadenoma) or malignant (cystadenocarcinoma). Descriptions of the fine‐needle aspiration (FNA) findings of these neoplasms have heretofore emphasized malignant cytologic characteristics. in the following, we present a summary of a study of FNA characteristics from ten patients with cystic mucinous neoplasms, four of whom have correlating histologic material. in this study, we found a spectrum of cytologic features ranging from completely benign appearing to obviously malignant. We discuss cystic mucinous pancreatic tumors and the associated FNA findings helpful in diagnosis and categorization of these neoplasms. Also, we suggest the inclusion of a new entity in the mucinous neoplasm category. © 1995 Wiley‐ Liss, Inc.
Comparative cytologic findings of in situ and invasive adenocarcinoma of the uterine cervix
Authors: Keyhani‐Rofagha S. , Brewer J. , Prokorym Patricia 
Published: February 2007

AbstractThe cytologic findings in 13 cases of cervical adenocarcinoma in situ (mean age 33.9 yr) were compared with those in 9 cases of cervical invasive adenocarcinoma (mean age 45.7 yr). All diagnoses were confirmed by biopsy. the major differences found were that a necrotic background (66% invasive vs. 0% in situ) and macronucleoli (77% invasive vs. 0% in situ) were more common in invasive cases, whereas associated squamous‐cell dysplasia (69% in situ vs. 0% invasive) was more common in in situ cases. Other differences included syncytial tissue fragments with irregular cell borders, frequent cell drop‐off, and markedly atypical single columnar cells (or markedly atypical naked nuclei) seen more commonly in invasive cases, whereas monolayer sheets and/or syncytial tissue fragments with smooth borders and rare cell drop‐off were more common in in situ cases. Although none of these features is diagnostic individually, in combination they are helpful in distinguishing between in situ and invasive adenocarcinoma.Nine of 13 of the in situ cases showed associated squamous‐cell dysplasia. in all nine of these cases, the glandular dysplasia was overlooked or underestimated in severity on original cytologic diagnosis. This suggests that the presence of a squamous lesion may lead to decreased detection of glandular lesions, perhaps because the features of squamous lesions are more well known; thus they are more easily recognized, at the expense of glandular lesions. All invasive adenocarcinomas were identified as carcinoma in the original diagnosis with seven specified as invasive adenocarcinomas. © 1995 Wiley‐ Liss, Inc.
Subcutaneous masses of the scalp and forehead: Diagnosis by fine‐needle aspiration
Authors: Bardales Ricardo H. , Stanley Michael W. 
Published: February 2007

AbstractWe report our cytologic findings and clinical correlations in benign (N = 2) and malignant (N = 16) subcutaneous masses of the scalp (N = 15) and forehead (N = 3), studied by fine‐needle aspiration (FNA). Diagnoses were divided in 3 groups: (1) Scalp plasmacytoma (as a manifestation of multiple myeloma) (6 cases) was the most frequent diagnosis. in one patient it was the presenting manifestation of the disease. (2) Miscellaneous malignancies included 8 carcinomas, 1 melanoma, and 1 malignant lymphoma. the scalp or forehead mass was the initial presentation and FNA was the initial diagnostic approach in five patients. (3) A single case each of pilar‐type keratinous cyst and hematoma were the only benign masses encountered. in conclusion, a significant number of subcutaneous masses of the scalp or forehead represent metastatic or systemic malignancies, and they may be the initial manifestation of the disease. Rapid and accurate diagnosis by FNA provides guidelines for appropriate therapy, especially in those patients who present with advanced disease. © 1995 Wiley‐ Liss, Inc.
Renal hydatid cyst: Urinary cytological diagnosis
Authors: Noi Ivan , Cohen Isaac , Loberant Norman 
Published: February 2007

AbstractEchinococcal disease is endemic in many areas of Asia, Europe, South America, the Near East, Australia, and New Zealand. Hepatic and pulmonary cysts are the most common presentation.Isolated renal hydatid cyst is an uncommon presentation of echinococcal disease, since renal involvement occurs in only 2–3% of cases. We present the case of a young man with renal colic, in whom the diagnosis of renal hydatid disease was established cytologically.Urine cytology, performed because of persistent hematuria, revealed scolices of Echinococcus granulosus and prompted further imaging investigation, and, ultimately, surgical treatment. © 1995 Wiley‐ Liss, Inc
Pilomatrixoma: A description of two cases diagnosed by fine‐needle aspiration
Authors: Ortiz Javier , Macías Carmen García , Abad Mar , Flores Teresa , Paz José I. , Bullón Agustín 
Published: February 2007

AbstractThe present work reports on the findings obtained by fine‐needle aspiration of two pilomatrixomas located on the upper limbs whose diagnosis was confirmed histologically. in both cases, the cytology disclosed a proliferation of small round basaloid cells that were dispersed and grouped in clusters together with squamous cells and abundant multinucleate giant cells. the differential diagnosis with other neoplasms is discussed. © 1995 Wiley‐ Liss, Inc.
Neuroendocrine carcinoma of the thymus: Aspiration biopsy, immunocytochemistry, and clinicopathologic correlates
Authors: Gherardi Giorgio , Marveggio Cristina , Placidi Antonio 
Published: February 2007

AbstractWe report three cases of well‐differentiated neuroendocrine carcinoma originating primarily in the anterior mediastinum which had been initially investigated by fine‐needle aspiration cytology in conjunction with immunocytochemistry and subsequently recognized as thymic in origin. Aspirates consisted of loosely cohesive or aggregated medium sized elements with round to oval nuclei and scanty cytoplasm. in all cases the Romanowsky stain provided an excellent delineation of definite paranuclear inclusion‐like structures having a semicircular or discoid appearance which appeared to contain cytokeratin by immunocytochemical studies and were very similar to the intermediate filament paranuclear “buttons” found in neuroendocrine Merkel cell carcinoma of the skin. This appears to be a novel cytologic observation for thymic neuroendocrine carcinoma. We discuss the significance of the above cytologic and immunocytochemical findings and their possible role in the diagnosis of thymic neuroendocrine carcinoma by fine‐needle aspiration biopsy. © 1995 Wiley‐ Liss, Inc.
Fine‐needle aspiration cytology of adenoid (Acantholytic) squamous‐cell carcinoma
Authors: Dodd Leslie G. 
Published: February 2007

AbstractAdenoid squamous‐cell carcinoma (ASCCa) is an uncommon cancer which occurs most frequently in the skin of the head and neck region of elderly, sun‐exposed individuals. Histologically, ASCCa is characterized by gland‐like, “adenoid” cell groups with a central, detached acantholytic cellular component and an intact peripheral rim of cells. the cytological features of five fine‐needle aspiration cytology (FNAC) samples from four patients with primary or metastatic ASCCa are presented. These were assessed for features which would allow distinction of this variant from conventional squamous carcinoma. the adenoid component was represented in FNAC by intact, sometimes three‐dimensional cell groups simulating glandular structures. Also present were cells in short chains of two or three in single cell files and scattered, individual dyskeratotic cells. Individual cells had rounded, accentuated borders, cytoplasmic keratinization, and often pyknotic nuclei, representing acantholytic cells from the adenoid “lumens.” Features of malignancy, including cellular atypia and increased mitotic rate, were present allowing for distinction between ASCCa and benign acantholytic processes such as pemphigus. © 1995 Wiley‐ Liss, Inc.
Ultrasound guided fine‐needle aspiration cytology: Diagnosis of hydatid disease of the abdomen and thorax
Authors: Das Dilip K. , Bhambhani Suresh , Pant Chandra S. 
Published: February 2007

AbstractEight cases of hydatid disease of the abdomen and thorax were diagnosed by fine‐needle aspiration (FNA) cytology under ultrasound guidance. the age of the patients ranged from 28 to 60 yr with a median of 34.5 yr; the male to female ratio was 2:6. None of the cases were diagnosed clinically as hydatid diseases but following ultrasonography suspicion of hydatid cyst was raised in two cases. the locations of cysts were the liver in six cases, the lung in one case, and the mediastinum in one case. FNA yielded clear fluid in five cases and turbid fluid in three cases. Laminated cyst wall, scolices, and hooklets were observed in one case, scolices and hooklets were present in two cases, and laminated cyst wall along with hooklets were seen in two cases. the remaining three cases showed only laminated cyst walls which yielded positive reaction with periodic acid‐Schiff reaction. Inflammatory cell reaction in the form of neutrophils was observed in four cases, including the three cases where turbid fluid was aspirated. Epithelioid cell reaction was present in one case. None of our eight cases showed any untoward allergic reaction following FNA. © 1995 Wiley‐ Liss, Inc.
Significance of endothelium in the fine‐needle aspiration biopsy diagnosis of hepatocellular carcinoma
Authors: Pitman Martha Bishop , Szyfelbein Wanda M. 
Published: February 2007

AbstractWe reviewed fine‐needle aspiration biopsies (FNAB) of hepatocellular carcinoma (HCC) (n = 35), benign hepatic processes (n = 35), cholangiocarcinoma (CC) (n = 6), and metastatic tumors (n = 100) to evaluate the significance of endothelium present either peripherally‐wrapping around groups of cells, (peripheral endothelium (PE)), or transgressing sheets of cells (transgressing endothelium (TE)), in distinguishing these lesions. These patterns were assessed as absent, focal, or prominent.Thirty‐three of 35 (94%) HCCs contained either focal or prominent PE or TE, compared to only 3 of 35 (9%) benign hepatocytic lesions. Only one benign lesion contained a prominent endothelial component (TE only). Two cases of HCC failed to contain endothelium, one fibrolamellar variant and one well‐differentiated HCC. These differences were statistically significant (P < 10–5, sensitivity 94%, specificity 91%, and positive predictive value [PPV] 92%).Neither pattern of endothelium was present in any CC or metastatic tumor. These differences were also statistically significant (P < 10–5, sensitivity 94%, and specificity and PVP 100%).We conclude that the presence of endothelium, at least focally in either one or both distinctive patterns, is highly sensitive and specific for HCC and aides in distinguishing it from benign hepatocytic lesions, CC, and metastases. © Wiley‐Liss, Inc.
Extragonadal germ cell tumors: A fine‐needle aspiration biopsy study
Authors: Collins Kim A. , Geisinger Kim R. , Wakely Paul E. , Olympio Georgia , Silverman Jan F. 
Published: February 2007

AbstractGerm cell tumors (GCT) are neoplasms that originate predominately in the ovary and testis. Tumors of germ cell origin only very uncommonly arise in extragonadal sites. We have diagnosed ten primary malignant extragonadal GCT arising in the mediastinum, retroperitoneum, liver, and sacrococcygeal region by fine‐needle aspiration biopsy (FNAB). Patient ages ranged from 1 to 54 years; the majority were males. Our series included three seminomas, three yolk sac tumors (YST), one choriocarcinoma, one embryonal carcinoma, and two mixed, poorly differentiated GCT. in aspirates, seminomatous elements are dissociated with uniform mononucleate cells having large vesicular nuclei and prominent nucleoli. A tigroid background is produced with Diff‐Quik—stained smears. YST yields cohesive clusters of cells with large nuclei, vacuolated cytoplasm, and extracellular hyaline matrix (spheres or hyaline globules). Giant multinucleate tumor cells are seen in choriocarcinoma. Embryonal carcinoma yields cellular smears of hyperchromatic cells with scant cytoplasm arranged predominantly in glandular or papillary formations. Ultrastructural (four cases) and immunocytochemical (seven cases) studies of aspirated material corroborated our cytologic interpretations. Aneuploid tumor cells were found by flow cytometry in aspirated material from a YST. Subsequent histologic examinations were performed on eight, and all were confirmatory. Although extragonadal GCT are relatively uncommon, they need to be considered in FNAB material from midline mass lesions. Ancillary studies were useful in confirming their diagnosis. © Wiley‐Liss, Inc.
Melanoma with signet‐ring cells in a peritoneal effusion
Authors: Niemann Theodore H. , Thomas Patricia A. 
Published: February 2007

AbstractMelanoma may occasionally give rise to a malignant effusion and when this occurs it can present a challenging differential diagnosis. We present such a patient who developed a peritoneal effusion. Cytologic examination of the peritoneal fluid revealed individual malignant cells with prominent cytoplasmic vacuoles raising the possibility of a signet‐ring cell adenocarcinoma. Immunohistochemical studies were indicative of a malignant melanoma. in this case we believe that the cytoplasmic vacuoles may be a degenerative phenomenon and as such may represent another mechanism for the development of a signet‐ring morphology in malignant melanoma. © Wiley‐Liss, Inc.
Two unusual benign lesions of the neck masquerading as malignancy on fine‐needle aspiration cytology
Authors: Dundas Kristy E. , Wong Maria P. , Suen Kenneth C. , Finley James L. 
Published: February 2007

AbstractTwo cases of unusual benign tumors of the neck are described, both of which were initially misdiagnosed on cytology as carcinomas. Fine‐needle aspiration findings in each case demonstrated a pleomorphic population of cells including bizarre multi‐nucleated giant cells, the latter raising the false impression of malignancy. However, on review the cytological appearances of the tumors, a pleomorphic lipoma and a carotid body tumor, were characteristic. the correct diagnosis in each case would have been made or suggested if the pathologist had been familiar with the cytologic features characteristic of the lesion and the differential diagnosis of the head and neck tumors. in addition, the point is made that adequate clinical information is essential for the pathologist if all relevant conditions are not to be missed in the differential diagnosis.
Serous effusion cytology in gynecologic malignant mixed müllerian tumors
Authors: Modzelewski Joseph R. , Silverman Jan F. , Berns Lisa A. , Sobieski Michael W. , Finley James L. 
Published: February 2007

AbstractWe reviewed 51 serous effusions (50 peritoneal/one pleural) from 38 patients with uterine (30 cases) and ovarian (eight cases) malignant mixed Müllerian tumors (MMMT). There were 16 patients (42%) with positive effusion cytology specimens; 13 cases (81%) were diagnosed as adenocarcinoma with three cases (19%) interpreted as having a sarcomatous component. Eight of 16 positive effusion specimens had cell block material available for immunoperoxidase (IP) study that included cytokeratin (AE1/3), vimentin, muscle specific actin (HHF) and S‐100 protein to determine if unsuspected mesenchymal components were present in the cases originally diagnosed as carcinoma (six cases), or sarcomas (two cases). in the six cases originally interpreted as carcinoma, three were diagnosed as adenocarcinoma and three as poorly differentiated carcinoma. All three of the cases considered adenocarcinoma and two of those diagnosed as poorly differentiated carcinoma reacted only with AE1/3 and vimentin. the remaining case, considered a poorly differentiated carcinoma, stained only with vimentin. in the two cases having cell blocks interpreted as having a sarcomatous component, only vimentin was positive in one while AE1/3, vimentin, HHF, and S‐100 were positive in the other. the case where all immunohistochemical stains were reactive contained both carcinomatous and sarcomatous components. in the three cases considered sarcomatous, the cytomorphologic features helpful in the recognition of a mesenchymal component included a dissociated smear pattern of pleomorphic round to oval cells and/or spindle cells. in retrospect, the IP stains did not alter any of the original diagnoses. From our series, we conclude that IP stains performed on serous effusions in cases of unsuspected MMMT are generally not helpful unless the cytomorphology is suspicious for a malignant mesenchymal component. to the best of our knowledge, we believe this to be the largest series reporting the effusion cytology findings in MMMT. © 1995 Wiley‐ Liss, Inc.
Intraductal carcinoma in a male breast: Diagnosis by nipple discharge cytology
Authors: Hirschman Scott A. , Hoda Syed A. , May Michael , Cody Hiram S. 
Published: February 2007

AbstractWe describe a case of intraductal carcinoma (comedo type) in a 50‐yr‐old male. the patient had presented with a bloody nipple discharge, which had shown malignant cells on cytologic examination. in current clinical practice, the use of nipple discharge cytology as a screening and diagnostic tool for breast carcinoma is largely supplemental; however, this case illustrates the occasional utility of nipple discharge cytology in the diagnosis of early breast carcinoma. © 1995 Willey‐ Liss, Inc.
Alteration of wilms' tumor staging by cytologic detection of malignant cells in chylous ascites
Authors: Baliga Mithra , Holmquist Nelson , Warrier Rajshekaran P. 
Published: February 2007

AbstractAccurate staging as per National Wilms' Tumor Study (NWTS) criteria is essential for therapy of Wilms' tumor. We report a unique case of a 9‐mo‐old white male in whom the diagnosis based upon clinical, radiological, surgical, and initial histopathologic findings was Stage I Wilms' tumor without regard to a positive cytologic examination of a small amount (5 ml) of chylous ascitic fluid obtained intraoperatively. This problem was clarified later at the NWTS panel review when the deeper recuts of a renal hilar lymph node revealed a single cluster of Wilms' tumor cells in capsular sinus, resulting in upstaging of tumor to Stage III. the significance of these findings in relation to staging will be discussed. © 1995 Willey‐ Liss, Inc.
Carcinoid tumor of the renal pelvis: Report of a case with positive urine cytology
Authors: Rudrick Brian , Nguyen Gia‐khanh , Lakey William H. 
Published: February 2007

AbstractA case of histologically and ultrastructurally confirmed carcinoid tumor of the renal pelvis is reported. the patient's urine sediment showed a few groups and sheets of polygonal malignant cells with scant cytoplasm and oval nuclei displaying chromatin clumping and micronucleoli. © 1995 Willey‐ Liss, Inc.
Efficacy of automated cervical cytology screening
Authors: Slagel Daniel D. , Zaleski Sue , Cohen Michael B. 
Published: February 2007

AbstractThe Papanicolaou stained cervicovaginal smear (Pap smear) is a gynecologic cytologic screening tool that has dramatically reduced the incidence and mortality of cervical cancer. Recently, a number of problems with the Pap smear test, including severe cytotechnologist shortages, lack of internal quality controls, and high false negative rates have been emphasized by the scientific community and the general public. To address some of these problems, there has been increased development of a number of automated and semiautomated cytologic screening systems.A semiautomated screening system (PAPNET®) was used to retrospectively evaluate 527 conventionally prepared Pap smears from 500 consecutive unselected patients. This system scanned the slides and displayed 128 of the most “abnormal” areas of each slide on a monitor. A screener reviewed these “abnormal” images in a blinded fashion and decided whether they represented variants of normal cytology, were inadequate for evaluation, or were abnormal and warranted manual review of the material. The screener's evaluations were then compared to the previously made diagnosis and discrepancies were reviewed.After review of the images from 500 patients, 343 (69%) were deemed to be normal cytology, 140 (28%) were abnormal and needed manual review, and 17 (3%) were inadequate. Of the 343 called normal using this system, 338 were previously called normal and five patients were previously diagnosed with either atypical squamous cells of undetermined significance (ASQUS) or low grade squamous intraepithelial lesions (LGSIL). Of the 140 thought to need review, 43 were previously diagnosed with squamous or glandular disease and 97 were previously diagnosed as normal. Slides from the apparent false negatives and false positives were again reviewed in a blinded fashion. Of the 97 thought to need review by the automated system but with previously normal diagnosis, 15 additional cases were thought to have cytopathic changes (12 ASQUS and 3 LGSIL). Of the five patients that were called normal using the automated review but with previous disease, only two were felt to be true false negatives.Semiautomated Pap smear screening appears to be a sensitive as well as specific method for the identification of cervical pathology. Further, it may be incorporated as a mechanism for quality control in the laboratory. © 1995 Wiley‐Liss, Inc.
Primary and metastatic high‐grade carcinomas of the salivary glands: A cytologic‐histologic correlation study of twenty cases
Authors: Stanley Michael W. , Bardales Ricardo H. , Farmer Charles E. , Frierson Henry F. , Suhrland Mark , Powers Celeste N. , Rollins Susan D. 
Published: February 2007

AbstractWe reviewed the clinical and fine‐needle aspiration (FNA) findings in 20 patients with poorly differentiated carcinomas presenting initially as parotid or as submandibular masses. There were 11 primary tumors and nine metastatic malignancies in 14 males and six females ranging in age from 39 to 89 yr (median = 66). The tumor types included three primary carcinomas with oncocytic features, three additional cases of high‐grade parotid carcinoma, one case of primary neuroendocrine carcinoma, two examples of malignant mixed tumor, one high‐grade mucoepidermoid carcinoma, and a single example of malignant lymphoepithelial lesion. Six patients with metastatic carcinoma had previous diagnoses of malignancy. In the three remaining individuals, primary carcinomas of the lung (two cases), and an unknown primary site presented initially as parotid masses. Five examples of metastatic squamous cell carcinoma, one metastatic basal cell carcinoma, and two metastatic renal cell carcinomas were identified. One parotid lymphoepithelioma was interpreted cytologically as an atypical lymphoproliferative process suggestive of Hodgkin's disease. Nineteen cases (95%) were correctly classified as carcinoma at the time of FNA. High‐grade carcinomas aspirated from the parotid may be primary, but are frequently metastatic to either the gland, or to an intraparotid lymph node. Our experience indicates that some metastatic carcinomas present at this site, without a previous history of malignancy. Distinguishing primary from metastatic lesions has important therapeutic implications. © 1995 Wiley‐Liss, Inc.