bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bumetanide enhances phenobarbital efficacy in a neonatal seizure model
Authors: Dzhala Volodymyr I. , Brumback Audrey C. , Staley Kevin J. 
Published: October 2007

AbstractObjectivesHigh levels of expression of the Na+‐K+‐2Cl− (NKCC1) cotransporter in immature neurons cause the accumulation of intracellular chloride and, therefore, a depolarized Cl− equilibrium potential (ECl). This results in the outward flux of Cl− through GABAA channels, the opposite direction compared with mature neurons, in which GABAA receptor activation is inhibitory because Cl− flows into the cell. This outward flow of Cl− in neonatal neurons is excitatory and contributes to a greater seizure propensity and poor electroencephalographic response to GABAergic anticonvulsants such as phenobarbital and benzodiazepines. Blocking the NKCC1 transporter with bumetanide prevents outward Cl− flux and causes a more negative GABA equilibrium potential (EGABA) in immature neurons. We therefore tested whether bumetanide enhances the anticonvulsant action of phenobarbital in the neonatal brainMethodsRecurrent seizures were induced in the intact hippocampal preparation in vitro by continuous 5‐hour exposure to low‐Mg2+ solution. The anticonvulsant efficacy of phenobarbital, bumetanide, and the combination of these drugs was studiedResultsPhenobarbital failed to abolish or depress recurrent seizures in 70% of hippocampi. In contrast, phenobarbital in combination with bumetanide abolished seizures in 70% of hippocampi and significantly reduced the frequency, duration, and power of seizures in the remaining 30%InterpretationThus, alteration of Cl− transport by bumetanide enables the anticonvulsant action of phenobarbital in immature brain. This is a mechanistic demonstration of rational anticonvulsant polypharmacy. The combination of these agents may comprise an effective therapy for early‐life seizures. Ann Neurol 2007
Arterial compliance and retinal vascular caliber in cerebrovascular disease
Authors: Cheung Ning , Islam F. M. Amirul , Jacobs David R. , Sharrett A. Richey , Klein Ronald , Polak Joseph F. , Cotch Mary F. , Klein Barbara E. , Ouyang Pamala , Wong Tien Y. 
Published: October 2007

AbstractObjectiveArterial stiffness is a newly recognized risk factor for stroke. Whether this is mediated by small‐ or large‐artery disease is unknown. In this study, we examined the relationship between arterial stiffness and retinal vascular caliber.MethodsA cross‐sectional, population‐based study of 5,731 participants (aged 45–84 years) who were free of clinical cardiovascular disease (the Multi‐Ethnic Study of Atherosclerosis). Retinal arteriolar and venular calibers were measured from retinal photographs according to standardized protocols. Small‐ and large‐artery compliance was determined from pulse contour analysis.ResultsAfter adjusting for age, sex, blood pressure, diabetes, smoking, lipid profile, and other risk factors, reduced large‐artery compliance was associated with smaller retinal arteriolar caliber; each standard deviation decrease in large‐artery compliance was associated with a 0.70μm (p = 0.002) decrease in retinal arteriolar caliber. After adjusting for the same set of risk factors, reduced small‐artery compliance was associated with wider retinal venular caliber; each standard deviation decrease in small artery compliance was associated with a 1.43μm (p = 0.001) increase in retinal venular caliber. These associations remained significant after further adjustments for large‐vessel atherosclerosis (carotid intima‐media thickness, coronary artery calcium, and ankle–arm index).InterpretationReduced arterial wall compliance in large arterial beds is associated with retinal arteriolar narrowing, whereas reduced arterial wall compliance in small arterial beds is associated with retinal venular widening. These data may provide further insights into the effects of altered arterial stiffness on the cerebral microcirculation. Ann Neurol 2007
Organometallic based biologically active compounds: synthesis of mono‐ and di‐ethanolamine derived ferrocenes with antibacterial, antifungal and cytotoxic properties
Authors: Chohan Zahid H. , Naseer Muhammad M. 
Published: October 2007

AbstractCondensation reactions of 1,1′‐diacetylferrocene with ethanolamine were studied. The obtained compounds were further investigated for their ligation and biological properties with Co(II), Cu(II), Ni(II) and Zn(II) metal ions. The synthesized compounds were characterized by their physical, spectral and analytical properties and screened for their antibacterial properties against pathogenic bacterial strains, e.g. Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis, Staphylococcus aureus and Salmonella typhi and for antifungal activity against Trichophyton longifusus, Candida albicans, Aspergillus flavus, Microsporum canis, Fusarium solani and Candida glaberata using the agar‐well diffusion method. All the compounds have shown good antibacterial and antifungal activity, which increased on coordination with the metal ions, thus introducing a potential class of organometallic‐based antibacterial and antifungal agents. Brine shrimp bioassay was also carried out for in vitro cytotoxic properties against Artemia salina. Copyright © 2007 John Wiley & Sons, Ltd.
Use of synthetic signal sequences to explore the protein export machinery
Authors: Clérico Eugenia M. , Maki Jenny L. , Gierasch Lila M. 
Published: October 2007

AbstractThe information for correct localization of newly synthesized proteins in both prokaryotes and eukaryotes resides in self‐contained, often transportable targeting sequences. Of these, signal sequences specify that a protein should be secreted from a cell or incorporated into the cytoplasmic membrane. A central puzzle is presented by the lack of primary structural homology among signal sequences, although they share common features in their sequences. Synthetic signal peptides have enabled a wide range of studies of how these “zipcodes” for protein secretion are decoded and used to target proteins to the protein machinery that facilitates their translocation across and integration into membranes. We review research on how the information in signal sequences enables their passenger proteins to be correctly and efficiently localized. Synthetic signal peptides have made possible binding and crosslinking studies to explore how selectivity is achieved in recognition by the signal sequence‐binding receptors, signal recognition particle, or SRP, which functions in all organisms, and SecA, which functions in prokaryotes and some organelles of prokaryotic origins. While progress has been made, the absence of atomic resolution structures for complexes of signal peptides and their receptors has definitely left many questions to be answered in the future. © 2007 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 90: 307–319, 2008.This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com
Amine‐Controlled Assembly of Metal—Sulfite Architecture from 1D Chains to 3D Framework.
Authors: Austria Cristina , Zhang Jian , Valle Henry , Zhang Qichun , Chew Emily , Nguyen Dan‐Tam , Gu J. Y. , Feng Pingyun , Bu Xianhui 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Chemical Bonding in TiSb2 and VSb2: A Quantum Chemical and Experimental Study
Authors: Armbruester Marc , Schnelle Walter , Schwarz Ulrich , Grin Yuri 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Study of Ba3MIIMIVWO9 (MII: Ca, Zn; MIV: Ti, Zr) Perovskite Oxides: Competition Between 3C and 6H Provskite Structures.
Authors: Mani Rohini , Selvamani P. , Joy Joby E. , Gopalakrishnan J. , Mandal Tapas Kumar 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Tuning of Metal—Metal Bonding and Magnetism via the Electron Count in GaxV4‐yCryS8.
Authors: Bichler Daniel , Johrendt Dirk 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
EXAFS Study of Aqueous ZrIV and ThIV Complexes in Alkaline CaCl2 Solutions: Ca3[Zr(OH)6]4+ and Ca4[Th(OH)8]4+.
Authors: Brendebach B. , Altmaier M. , Rothe J. , Neck V. , Denecke M. A. 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Nonaqueous Sol—Gel Synthesis of a Nanocrystalline InNbO4 Visible‐Light Photocatalyst.
Authors: Zhang Lizhi , Djerdj Igor , Cao Minhua , Antonietti Markus , Niederberger Markus 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Hydrothermal Synthesis, Characterization and Acid Catalytic Activity of Nano Ce—La Oxide Powder.
Authors: Hu Yucai , Yin Ping , Liang Tao , Zhang Jiang , Zhu Dangdong 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
One‐Dimensional Indium Sulfides with Transition Metal Complexes of Polyamines.
Authors: Zhou Jian , Bian Guo‐Qing , Zhang Yong , Zhu Qin‐Yu , Li Chun‐Yin , Dai Jie 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Porous Nonlinear‐Optical Material Based on a Twin‐Nest‐Shaped Heterothiometallic Cluster: {[NH4] [W2O2S6Cu6I3 (4,4′‐bipy)4]×5H2O}n.
Authors: Huang Kexuan , Song Yinglin , Pan Zhaorui , Li Yizhi , Zhuo Xin , Zheng Hegen 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Acyclic β‐Amino Acid Catalyzed Asymmetric anti‐Selective Mannich‐Type Reactions.
Authors: Dziedzic Pawel , Cordova Armando 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Stereoselective Reactions of Vinyl(phenyl)iodonium Salts with Sodium Selenide, Sodium Sulfide, Sodium Azide and Potassium Thiocyanate.
Authors: Yan Jie , Jin Hongwei , Chen Zhenchu 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Preparation of Enantiomerically Pure (3E)‐Alkyl‐4‐(hetero‐2‐yl)‐2‐hydroxybut‐3‐enoates (I) by Candida parapsilosis ATCC 7330 Mediated Deracemization and Determination of the Absolute Configuration of (3E)‐Ethyl‐4‐(thiophene‐2‐yl)‐2‐hydroxybut‐3‐enoate.
Authors: Vaijayanthi T. , Chadha Anju 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Rhodium‐ and Iridium‐Catalyzed Double Hydroalkoxylation of Alkynes — An Efficient Method for the Synthesis of O,O‐Acetals: Catalytic and Mechanistic Studies.
Authors: Messerle Barbara A. , Vuong Khuong Q. 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Ring‐Closing Reaction of Allenic/Propargylic Anions Generated by Base Treatment of Sulfonylallenes.
Authors: Kitagaki Shinji , Teramoto Satoshi , Mukai Chisato 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Observations on the Direct Amidocyclopropanation of Alkenes Using Organozinc Carbenoids.
Authors: Motherwell William B. , Begis Guillaume , Cladingboel David E. , Jerome Laure , Sheppard Tom D. 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
The First Cyclopropanation Reaction of Unmasked α,β‐Unsaturated Carboxylic Acids: Direct and Complete Stereospecific Synthesis of Cyclopropanecarboxylic Acids Promoted by Sm/CHI3.
Authors: Concellon Jose M. , Rodriguez‐Solla Humberto , Simal Carmen 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Gold‐Catalyzed Intramolecular Redox Reaction of Sulfinyl Alkynes: Efficient Generation of α‐Oxo Gold Carbenoids and Application in Insertion into R—CO Bonds.
Authors: Li Guotao , Zhang Liming 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Clean and Highly Selective Oxidation of Alcohols by the PhI(OAc)2/Mn(TPP)CN/Im Catalytic System.
Authors: Karimipour Gholam Reza , Shadegan Hamid Asadpour , Ahmadpour Roxana 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Halogenation of Carbonyl Compounds by an Ionic Liquid, [AcMIm]X, and Ceric Ammonium Nitrate (CAN).
Authors: Ranu Brindaban C. , Adak Laksmikanta , Banerjee Subhash 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Domino Metathesis Involving ROM‐RCM of Substituted Norbornenes. Rapid Access to Densely Functionalized Tricyclic Bridged and Condensed Ring Systems.
Authors: Malik Chanchal K. , Ghosh Subrata 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Iodine Catalyzed Selective O‐Alkylation of Alcohols with Orthoesters.
Authors: Kumar H. M. S. , Anjaneyulu S. , Joyasawal Sipak , Chakravarthy P. Pawan , Kumar V. Naveen , Yadav J. S. 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Small Organic Molecule in Enantioselective, Direct Aldol Reaction “in Water”.
Authors: Aratake Seiji , Itoh Takahiko , Okano Tsubasa , Usui Takahiro , Shoji Mitsuru , Hayashi Yujiro 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Cyclopropanol‐Based Strategy for Subunit Coupling: Total Synthesis of (+)‐Spirolaxine Methyl Ether.
Authors: Keaton Katie A. , Phillips Andrew J. 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Photoinduced Diastereoselective Addition of Perfluoroalkyl Iodides to Acrylic Acid Derivatives for the Synthesis of Fluorinated Amino Acids.
Authors: Yajima Tomoko , Nagano Hajime 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Stereoselective Entry into Functionalized 1,2‐Diamines by Zinc‐Mediated Homologation of α‐Amino Acids.
Authors: Hoang Cam Thuy , Alezra Valerie , Guillot Regis , Kouklovsky Cyrille 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Mild and Efficient Method for the One‐Pot Monocarboxymethylation of Primary Amines.
Authors: Gibbs Timothy J. K. , Boomhoff Michael , Tomkinson Nicholas C. O. 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Organocatalytic Enantioselective Synthesis of Secondary α‐Hydroxycarboxylates.
Authors: Dodda Rajasekhar , Zhao Cong‐Gui 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Cobalt—Rhodium Heterobimetallic Nanoparticle‐Catalyzed Synthesis of α,β‐Unsaturated Amides from Internal Alkynes, Amines, and Carbon Monoxide.
Authors: Park Ji Hoon , Kim Sun Young , Kim Soo Min , Chung Young Keun 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Triphenylphosphine‐Catalyzed Michael Addition of Alcohols to Acrylic Compounds.
Authors: Liu Hai‐Ling , Jiang Huan‐Feng , Wang Yu‐Gang 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Efficient, Transition Metal Mediated, Sequential, Two‐ and Three‐Component Coupling Reactions for the Synthesis of Highly Substituted Five‐Membered Ring Carbocycles.
Authors: Coia Nicolas , Bouyssi Didier , Balme Genevieve 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
High‐Yielding One‐Pot Synthesis of Diaryliodonium Triflates from Arenes and Iodine or Aryl Iodides.
Authors: Bielawski Marcin , Olofsson Berit 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Stereoselective Monofluoromethylation of Primary and Secondary Alcohols by Using a Fluorocarbon Nucleophile in a Mitsunobu Reaction.
Authors: Prakash G. K. Surya , Chacko Sujith , Alconcel Steevens , Stewart Timothy , Mathew Thomas , Olah George A. 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
2‐Nitroso‐N‐arylanilines: Products of Acid‐Promoted Transformation of σH Adducts of Arylamines and Nitroarenes.
Authors: Wrobel Zbigniew , Kwast Andrzej 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of New Sterically Hindered Anilines.
Authors: Steele Barry R. , Georgakopoulos Spyros , Micha‐Screttas Maria , Screttas Constantinos G. 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Boron Trichloride Mediated Regioselective Claisen Rearrangement of Resorcinol Derivatives: Application to Resorcinol Carvonyl Ethers.
Authors: Ito Fumihiro , Fusegi Keiko , Kumamoto Takuya , Ishikawa Tsutomu 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
New BINOL Schiff Base as a Tridentate Ligand for Catalytic Asymmetric Addition of Diethylzinc to Aldehydes in the Presence of Titanium Tetraisopropoxide.
Authors: Liu Bing , Fang Cao , Dong Zhi‐Bing , Li Jin‐Shan 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
First Immobilization of Chiral Menthol‐Derived Picoline on Solid Support and Evaluation for Asymmetric Catalysis.
Authors: Pierrat Philippe , Fort Yves , Gros Philippe C. 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Enantioselective Trifluoromethylation of Aromatic Aldehydes Catalyzed by Combinatorial Catalysts.
Authors: Zhao Haitao , Qin Bo , Liu Xiaohua , Feng Xiaoming 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
N‐Heterocyclic Carbene‐Initiated α‐Acylvinyl Anion Reactivity: Additions of α‐Hydroxypropargylsilanes to Aldehydes.
Authors: Reynolds Troy E. , Stern Charlotte A. , Scheidt Karl A. 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Regio‐ and Stereoselective Cross‐Coupling of Substituted Olefins and Imines. A Convergent Stereoselective Synthesis of Saturated 1,5‐Amino Alcohols and Substituted Piperidines.
Authors: Takahashi Masayuki , Micalizio Glenn C. 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of New Halo‐Containing Enynes: Reaction of Lithium Acetylenides with 1,1,1‐Trihalo‐4‐alkoxy‐3‐buten‐2‐ones.
Authors: Martins Marcos A. P. , et al. et al. 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.