bluuebunny/crossref_metadata_2025_split huggingface dataset:
Two cases of gastric cancer with elevated serum levels of KL-6
Authors: Yanagisawa Naoe , Koide Naohiko , Fukai Harunari , Koyama Yoshinori , Ogihara Yuu , Ohya Maki 
Published: April 2024

Abstract
Background
The serum level of Krebs von den Lungen-6 (sKL-6) is a biomarker of interstitial pneumonia and has been reported to be elevated in patients with cancers. However, there have been few cases of gastric cancer (GC) with elevated sKL-6 that were treated by chemotherapy. We herein report two cases of GC with elevated sKL-6 that were treated with oxaliplatin plus S-1 (SOX) chemotherapy and discussed the resulting changes in sKL-6.

Case presentation
The first patient was a 79-year-old woman complaining of loss of appetite. Esophagogastroduodenoscopy (EGD) showed a type-3 tumor in the gastric antrum and biopsy specimens showed adenocarcinoma. Computed tomography (CT) showed multiple liver metastases. sKL-6 was elevated to 1,292 U/ml, but a CT revealed no obvious lesions of the lungs, including interstitial pneumonia. The tumor was diagnosed as GC with liver metastases and elevated sKL-6. Respiratory function data were normal. SOX therapy using oxaliplatin and S-1 was performed. After 3 courses of SOX therapy, CT showed reductions of the liver metastases as well as the primary tumor, and sKL-6 was decreased to 201 U/ml. After the 44 courses, sKL-6 was slightly elevated. Chest CT showed interstitial pneumonia and chemotherapy was stopped. The patient is still alive without any metastasis 72 months later. The second patient was a 69-year-old woman complaining of upper abdominal pain. EGD revealed a type-3 tumor in the gastric antrum showing adenocarcinoma with HER2-positive pathology. CT showed multiple node metastases around the abdominal aorta. sKL-6 was elevated to 2,239 U/ml, but a respiratory function test showed no abnormalities, and CT of the lungs showed no obvious lesions. The tumor was diagnosed as GC with distant node metastases and elevated sKL-6. The patient received SOX therapy combined with trastuzumab. After 6 courses, the size of the primary tumor and multiple node metastases were reduced, and sKL-6 was decreased to 284 U/ml.

Conclusions
These two cases suggest that sKL-6 may be important not only as an indicator of interstitial pneumonia in chemotherapeutic courses, but also as a tumor marker in GC patients with multiple metastases.
Exploring the effects of fitbit incentive on treatment outcomes in veterans undergoing intensive pain rehabilitation program
Authors: Toor Tiffany , Palyo Sarah , Schopmeyer Kathryn , Simmons Alan N. , Strigo Irina A. 
Published: April 2024

Abstract
Objective
This study compares clinical pain outcomes between patients in a pain treatment program that received a Fitbit, to patients that did not. We also explored: (1) cognitive, emotional, and psychological factors that may have impacted the decision to opt in to receiving a Fitbit; and (2) whether the choice to receive a Fitbit impacted changes in cognitive, emotional, and psychological factors following treatment.

Methods
Among 58 patients in a multidisciplinary pain treatment program at a Veterans Affairs Healthcare System hospital, 31 patients opted to receive a Fitbit as adjunct treatment, while 27 did not. This study utilized patient-reported and practitioner-collected data from the pain treatment program.

Results
Compared to the non-Fitbit group, the Fitbit group displayed a significant decrease in average pain intensity, however showed no correlation between Fitbit activity and average pain intensity. Additionally, treatment satisfaction was the only predictor of treatment group, when modeling pre- and post-treatment outcomes changes.

Conclusion
The implementation of a Fitbit may lead to improved pain intensity. Initial evidence suggests that opting to receive a Fitbit during a pain treatment program indicates treatment engagement leading to greater treatment satisfaction. Future work is needed to verify and expand upon this potential mechanism.
Public data homogenization for AI model development in breast cancer
Authors: Kilintzis Vassilis , Kalokyri Varvara , Kondylakis Haridimos , Joshi Smriti , Nikiforaki Katerina , Díaz Oliver , Lekadir Karim , Tsiknakis Manolis , Marias Kostas 
Published: April 2024

Abstract
Background
Developing trustworthy artificial intelligence (AI) models for clinical applications requires access to clinical and imaging data cohorts. Reusing of publicly available datasets has the potential to fill this gap. Specifically in the domain of breast cancer, a large archive of publicly accessible medical images along with the corresponding clinical data is available at The Cancer Imaging Archive (TCIA). However, existing datasets cannot be directly used as they are heterogeneous and cannot be effectively filtered for selecting specific image types required to develop AI models. This work focuses on the development of a homogenized dataset in the domain of breast cancer including clinical and imaging data.

Methods
Five datasets were acquired from the TCIA and were harmonized. For the clinical data harmonization, a common data model was developed and a repeatable, documented “extract-transform-load” process was defined and executed for their homogenization. Further, Digital Imaging and COmmunications in Medicine (DICOM) information was extracted from magnetic resonance imaging (MRI) data and made accessible and searchable.

Results
The resulting harmonized dataset includes information about 2,035 subjects with breast cancer. Further, a platform named RV-Cherry-Picker enables search over both the clinical and diagnostic imaging datasets, providing unified access, facilitating the downloading of all study imaging that correspond to specific series’ characteristics (e.g., dynamic contrast-enhanced series), and reducing the burden of acquiring the appropriate set of images for the respective AI model scenario.

Conclusions
RV-Cherry-Picker provides access to the largest, publicly available, homogenized, imaging/clinical dataset for breast cancer to develop AI models on top.

Relevance statement
We present a solution for creating merged public datasets supporting AI model development, using as an example the breast cancer domain and magnetic resonance imaging images.

Key points
• The proposed platform allows unified access to the largest, homogenized public imaging dataset for breast cancer.
• A methodology for the semantically enriched homogenization of public clinical data is presented.
• The platform is able to make a detailed selection of breast MRI data for the development of AI models.

Graphical Abstract
Investigating the role of VDR gene variants in multiple sclerosis susceptibility: a case–control study in Egypt
Authors: Hosni Hala Ashraf , Fouad Amr Mohamed , Ibrahim Noha Wael , Sharaf Sahar Abd El-Atty 
Published: April 2024

Abstract
Background
Multiple sclerosis (MS) is a chronic inflammatory disorder. Vitamin D has a major role in preventing inflammatory disorders as well as its role in the pathophysiology of MS. Vitamin D initiates its biological responses by binding to the nuclear vitamin D receptor (VDR). Several studies have been conducted over the last decade to investigate the relationship between VDR gene variants and the risk of MS, but the results have been inconsistent and inconclusive. The objective of this study is to investigate the association between the VDR gene variants (c.1025-49C>A) and (c.1056A>G) and MS susceptibility in a sample of the Egyptian population, and to shed light on its potential role in preventing inflammatory disorders and its impact on clinical outcomes and treatment using TaqMan Real-Time Polymerase Chain Reaction (PCR). This case-control study was conducted on 100 participants, categorized into two groups. The first group included 50 patients diagnosed with relapsing-remitting multiple sclerosis (RRMS) based on the Revised McDonald MS criteria, and the second group included 50 matched healthy participants. After collecting the blood samples, deoxyribonucleic acid (DNA) was extracted and detection of the VDR: c.1025-49C>A and VDR: c.1056A>G gene variants was done using TaqMan Real-Time PCR on all involved individuals.

Results
The distribution of the genotypes and alleles of VDR gene variants (c.1025- 49C>A) and (c.1056A>G) did not differ significantly between MS patients and healthy participants (P>0.05 in both).

Conclusion
Here we show in this study that there was no association between the risk of MS and the VDR gene variants (c.1025-49C>A) and (c.1056A>G) in a group of the Egyptian population which may have impact on MS therapy and outcome.
Impact of COVID-19 infections and vaccination on menstrual cycle symptoms in the south of Jordan: a cross-sectional study
Authors: Abu-Lubad Mohammad A. , Abu-Helalah Munir A. , QawaQzeh Mohammad S. , Alahmad Esra’a F. , Al-Tamimi Malak M. , Ruba’I Mohammad K. , Etoom Sahm H. , Alfayoumi Rawan K. , Aldaoudeyeh Fatima E. , AlAbabneh Ekram A. , Al-kharabsheh Ahlam M. , Alshraideh Hussam 
Published: April 2024

Abstract
Background
Several recent studies have highlighted the need for more evaluation of the impact of COVID-19 infections and vaccines on the reproductive system and menstruation. This study aimed to assess the impact of COVID-19 infection and vaccines on menstrual symptoms.

Methods
A cross-sectional survey utilizing face-to-face interviews from January 1 to 31 March 2022 was conducted in the city of Al-Karak in southern Jordan. The questionnaire included sociodemographic characteristics, medical and reproductive history, the contraceptive method used if any, menstrual cycle (MC) status, previous medical and drug history, and the impact of infection and vaccination on the MC.

Results
The study questionnaire was completed by 400 participants with a mean age of 32.1±12.6 years. Regarding the history of COVID-19 infections, 33.8% of the participants reported a history of confirmed COVID-19 infections, 77.8% of them did not report any menstrual changes following the infection, while the remaining 22.2% reported changes in menstruation. The most commonly reported post-COVID-19 manifestations were irregular (27.6%) and light menstrual cycle (MC) (24.15) or dysmenorrhea (24.1%). Heavy menstruation was reported by 17.2% of participants post-COVID-19 infection. Two-thirds of the study participants (66.6%) reported no changes in the MC following the administration of the COVID-19 vaccine. The most reported symptoms for those who experienced changes in the MC following the vaccination were irregular cycle (13.1%), heavy menstruation (7%), and light menstruation (7%). Other reported symptoms were dysmenorrhea (4.6%), intermenstrual bleeding (1.2%), and amenorrhea (0.5%).

Conclusion
This study revealed minor changes in the MC following COVID-19 infections and administration of the COVID-19 vaccine. These findings are consistent with published reports. It is recommended that future clinical trials for new vaccines for women of childbearing age include outcomes related to sex hormones and MC. Women should be encouraged to take the vaccines and report symptoms to healthcare professionals for further assessment.
Unveiling geniposide from Paederia foetida as a potential antihypertensive treatment: an integrated approach involving in vivo and computational methods
Authors: Koley Chanchal , Mondal Arijit , Dey Suddhsattya , Rawat Ravi , Mondal Anjan , Rangra Naresh Kumar , Urolagin Deeparani , Behera Padmacharan , Mohanty Dibya Lochan , Zafar Ameeduzzafar , Eyupoglu Volkan 
Published: April 2024

Abstract
Background
Hypertension is one of the burning topics in today’s world. Natural product can open a new window in the treatment as they are lesser side effect compared to synthetic compounds. Paederia foetida a naturally occurring plant has proven its biological importance in many aspects. In this present study, the ethanolic extract of Paederia foetida has effectively proven its antihypertensive activity against Amphetamine-induced hypertension.

Results
The study was carried out for 4 weeks with five different groups where the groups receiving Paederia foetida (400 mg/kg) for 4 weeks result in decrease in blood pressure and was found helpful in maintaining the sodium and potassium balance in rat’s serum. Amphetamine induces decreasing sodium level that can be countered by Paederia foetida whole plant extract. Geniposide, an active ingredient present in this plant, is having antihypertensive activity, so it was docked against different PDB IDs (3OLL, 3OLS, 5DX3, 5DXE & 6PIT), to find its anti-hypertension effectiveness through computational chemistry. The docking investigations identified that estrogen receptor (PDB ID: 3OLS) exhibited the highest possibility to be the site of action. Docking score of Geniposide with 3OLS was -8.91 which is quit comparable with the internal ligand Estradiol.

Conclusion
To assess the binding affinity of Geniposide with the estrogen receptor, an additional molecular dynamics simulation was conducted. The result strongly suggests that Geniposide has the potential to function as an activator of estrogen receptor through of β-ligand binding. This key finding reveals that Geniposide may serve as a potential in the treatment of hypertension by modulating the activity of the estrogen receptor.
Extent of Resection and Long-Term Outcomes for Appendiceal Adenocarcinoma: a SEER Database Analysis of Mucinous and non-Mucinous Histologies
Authors: Tsagkalidis Vasileios , Choe Jennie K. , Beninato Toni , Eskander Mariam F. , Grandhi Miral S. , In Haejin , Kennedy Timothy J. , Langan Russell C. , Maggi Jason C. , Pitt Henry A. , Alexander H. Richard , Ecker Brett L. 
Published: April 2024

Abstract
Background
Mucinous appendiceal adenocarcinomas (MAA) and non-mucinous appendiceal adenocarcinomas (NMAA) demonstrate differences in rates and patterns of recurrence, which may inform the appropriate extent of surgical resection (i.e., appendectomy versus colectomy). The impact of extent of resection on disease-specific survival (DSS) for each histologic subtype was assessed.

Patients and Methods
Patients with resected, non-metastatic MAA and NMAA were identified in the Surveillance, Epidemiology, and End Results database (2000–2020). Multivariable models were created to examine predictors of colectomy for each histologic subtype. DSS was calculated using Kaplan–Meier estimates and examined using Cox proportional hazards modeling.

Results
Among 4674 patients (MAA: n = 1990, 42.6%; NMAA: n = 2684, 57.4%), the majority (67.8%) underwent colectomy. Among colectomy patients, the rate of nodal positivity increased with higher T-stage (MAA: T1: 4.6%, T2: 4.0%, T3: 17.1%, T4: 21.6%, p < 0.001; NMAA: T1: 6.8%, T2: 11.4%, T3: 25.6%, T4: 43.8%, p < 0.001) and higher tumor grade (MAA: well differentiated: 7.7%, moderately differentiated: 19.2%, and poorly differentiated: 31.3%; NMAA: well differentiated: 9.0%, moderately differentiated: 20.5%, and 44.4%; p < 0.001). Nodal positivity was more frequently observed in NMAA (27.6% versus 16.4%, p < 0.001). Utilization of colectomy was associated with improved DSS for NMAA patients with T2 (log rank p = 0.095) and T3 (log rank p = 0.018) tumors as well as moderately differentiated histology (log rank p = 0.006). Utilization of colectomy was not associated with improved DSS for MAA patients, which was confirmed in a multivariable model for T-stage, grade, and use of adjuvant chemotherapy [hazard ratio (HR) 1.00, 95% confidence interval (CI) 0.81–1.22].

Conclusions
Colectomy was associated with improved DSS for patients with NMAA but not MAA. Colectomy for MAA may not be required.
Which Idea to Pursue? Gender Differences in Novelty Avoidance During Creative Idea Selection
Authors: Jin Mengzi , Chua Roy 
Published: April 2024

Despite women having made significant progress in the modern workforce, gender gaps are still evident in creative work. In this paper, we propose that, although women and men are equally capable of generating creative ideas, gender differences emerge during the idea-selection stage. Specifically, compared with men, women engage in higher novelty avoidance during idea selection—the degree to which one selects an idea that is less novel than the most novel idea one has generated. In two laboratory studies and a field survey involving creative professionals, we found significant gender differences in novelty avoidance during idea selection and identified women’s concerns about social backlash when pursuing highly novel ideas as one explanatory variable. We also experimentally manipulated gender compositions of the evaluation panel and found that women’s novelty avoidance tendency during idea selection was reduced when they were informed about the presence of women evaluators. Finally, novelty avoidance during idea selection has an inverted U-shaped relationship with idea success; because women tend to engage in higher novelty avoidance than men, novelty avoidance in women (but not men) has a negative impact on the success of their ideas. By examining gender dynamics at specific stages, our work offers theoretical and practical insights regarding gender disparities in creative work. Funding: M. Jin extends appreciation to the National Natural Science Foundation of China [Grants 72202003, 72091314, 72172006] for financial support. The authors also gratefully acknowledge the Singapore Ministry of Education’s Social Science Research Thematic Grant [Grant MOE2017-SSRTG-042]. Supplemental Material: The online appendix is available at https://doi.org/10.1287/orsc.2022.16176 .
Spectroscopic Characterization of the Chemical Changes Occurring in Soy Wood Composite Adhesives When Exposed to Moisture
Authors: Marcinko Joseph J. , Parker Anthony A. 
Published: April 2024

Abstract
Solid-state surface attenuated total reflectance Fourier transform infrared spectroscopy (SATR-FTIR) and solid-state nuclear magnetic resonance spectroscopy (SSNMR) were used to characterize the physiochemical changes in solid soy-flour adhesives upon exposure to water. Comparisons were made between adhesives that were prepared with and without the crosslinking chemical polyamideamine-epichlorohydrin (PAE). Comparisons were also made between neat monolithic adhesive films, and adhesives that were laminated to yellow poplar (Liriodendron tulipifera). FTIR data revealed that the relative surface concentration of water-soluble components on neat monolithic adhesives was higher prior to water-exposure as compared with the adhesive laminated to wood. Moreover, the chemical composition of the water-soluble extract was affected by PAE. After soaking in water, the water-soluble components were observed to dissolve and disappear from the surfaces of the adhesives, as well as from the surfaces of water-soaked wood-laminate specimens. Similarly, SSNMR results corroborated with the dissolution and disappearance of the water-soluble components from the neat monolithic adhesives after water soaking. Moreover, it was discovered that the water-soluble components have a plasticization effect when PAE is used as a crosslinker. The implications of these findings as they pertain to the mechanism of adhesion will be discussed.
Metastasis patterns and prognosis in young gastric cancer patients: A propensity score‑matched SEER database analysis
Authors: Zhang Hong , Cheng Xia , Guo Wenqin , Zheng Cheng , Zhang Yue , Jing Xiaoying , Qiao Hui 
Published: April 2024

Background
Whether young patients with metastatic gastric cancer (GC) had distinct metastasis patterns and survival outcomes from older patients remains controversial. The aim of the present study was to explore the metastasis patterns and prognostic factors in young patients and evaluate the survival outcome in comparison to their older counterparts.

Materials and methods
We identified patients with metastatic GC in the surveillance, epidemiology, and end results (SEER) database from 2010 to 2015. The patients were divided into two groups based on age at diagnosis: younger (≤40 years old) and older (>40 years old). We employed the chi‐squared test to compare the clinicopathological characteristics between the two age groups. Furthermore, we conducted survival analyses using Kaplan–Meier and Cox regression analyses. To balance disparities in baseline characteristics, we employed propensity score matching (PSM).

Results
We identified 5,580 metastatic GC patients from the SEER database, with 237 (4.2%) classified as younger and 5343 (95.8%) as older patients. A total of 237 pairs of patients were generated after adjustment by PSM. Patients in the younger group exhibited a higher proportion of bone-only metastases and a lower proportion of liver-only metastases compared with patients in the older group. Multivariate Cox regression analysis demonstrated that youth was an independent protective factor for overall survival (OS) before and after PSM, but not for gastric cancer-specific survival (GCSS). Among the younger group, patients with liver-only metastasis demonstrated the best prognosis, whereas patients with lung-only metastasis exhibited significantly worse survival outcomes compared with liver-only metastases, even comparable to that of bone metastasis.

Conclusions
Compared with the older group, the metastatic GC patients in the younger group exhibited more aggressive tumors but better prognoses. The metastasis pattern and its effect on the prognosis of GC varied by age group.
A Mereological Reading of the Dictum de Omni et Nullo
Authors: Corkum Phil 
Published: April 2024

Abstract
When Aristotle introduces the complete moods, he refers back to the dictum de omni et nullo, a semantic condition for universal affirmations and negations. There recently has been renewed interest in the question whether the dictum validates the assertoric syllogistic. I rehearse evidence that Aristotle provides a mereological semantics for universal affirmations and negations, and note that this semantics entails a nonstandard reading of the dictum, under which the dictum, in the presence of a minimal logical apparatus, indeed validates the assertoric syllogistic. I argue that this mereological validation offers advantages over recent discussions in Morison, Malink, Ebert and Vlasits.
25 Jahre KIBA – Rückblick und Ausblick
Authors: Georgy Ursula 
Published: April 2024

Zusammenfassung
Die „Konferenz der Informations- und Bibliothekswissenschaftlichen Ausbildungs- und Studiengänge“ (KIBA) feierte im Jahr 2023 ihr 25-jähriges Jubiläum. Dies ist Anlass genug, die Aktivitäten durch die KIBA und die damit verbundenen Entwicklungen insbesondere im Bereich der bibliotheks- und informationswissenschaftlichen Studiengänge über die Zeit hinweg zu skizzieren und an einigen Stellen auch einen Ausblick zu wagen.
Functional Finance and the Sustainability of Universal Basic Income
Authors: Widerquist Karl 
Published: April 2024

Abstract
“Functional finance” is an economic theory within the Post Keynesian school of thought. Especially in the form of Modern Monetary Theory (MMT), it has begun to have two big but opposite effects on the debate over Universal Basic Income (UBI). Some people state MMT in an exaggerated way that implies the government can spend all it wants on UBI or anything else without ever raising taxes or borrowing money as if government spending had no limits of any kind. Other people refer to MMT while arguing that any effort to maintain a livable level of UBI is unsustainable. This article discusses the functional finance implications for the cost and sustainability of UBI, arguing that neither of those exaggerated implications are correct. MMT doesn’t free us for the concern for how to support UBI with taxes, but neither does it give reason to believe UBI is any less sustainable.