bluuebunny/crossref_metadata_2025_split huggingface dataset:
Statins improve cardiac endothelial function to prevent heart failure with preserved ejection fraction through upregulating circRNA-RBCK1
Authors: Li Bin , Bai Wen-Wu , Guo Tao , Tang Zhen-Yu , Jing Xue-Jiao , Shan Ti-Chao , Yin Sen , Li Ying , Wang Fu , Zhu Mo-Li , Lu Jun-Xiu , Bai Yong-Ping , Dong Bo , Li Peng , Wang Shuang-Xi 
Published: April 2024

AbstractHeart failure with preserved ejection fraction (HFpEF) is associated with endothelial dysfunction. We have previously reported that statins prevent endothelial dysfunction through inhibition of microRNA-133a (miR-133a). This study is to investigate the effects and the underlying mechanisms of statins on HFpEF. Here, we show that statins upregulate the expression of a circular RNA (circRNA-RBCK1) which is co-transcripted with the ring-B-box-coiled-coil protein interacting with protein kinase C-1 (RBCK1) gene. Simultaneously, statins increase activator protein 2 alpha (AP-2α) transcriptional activity and the interaction between circRNA-RBCK1 and miR-133a. Furthermore, AP-2α directly interacts with RBCK1 gene promoter in endothelial cells. In vivo, lovastatin improves diastolic function in male mice under HFpEF, which is abolished by loss function of endothelial AP-2α or circRNA-RBCK1. This study suggests that statins upregulate the AP-2α/circRNA-RBCK1 signaling to suppress miR-133a in cardiac endothelial cells and prevent diastolic dysfunction in HFpEF.
SOXC are critical regulators of adult bone mass
Authors: Angelozzi Marco , Karvande Anirudha , Lefebvre Véronique 
Published: April 2024

AbstractPivotal in many ways for human health, the control of adult bone mass is governed by complex, incompletely understood crosstalk namely between mesenchymal stem cells, osteoblasts and osteoclasts. The SOX4, SOX11 and SOX12 (SOXC) transcription factors were previously shown to control many developmental processes, including skeletogenesis, and SOX4 was linked to osteoporosis, but how SOXC control adult bone mass remains unknown. Using SOXC loss- and gain-of-function mouse models, we show here that SOXC redundantly promote prepubertal cortical bone mass strengthening whereas only SOX4 mitigates adult trabecular bone mass accrual in early adulthood and subsequent maintenance. SOX4 favors bone resorption over formation by lowering osteoblastogenesis and increasing osteoclastogenesis. Single-cell transcriptomics reveals its prevalent expression in Lepr+ mesenchymal cells and ability to upregulate genes for prominent anti-osteoblastogenic and pro-osteoclastogenic factors, including interferon signaling-related chemokines, contributing to these adult stem cells’ secretome. SOXC, with SOX4 predominantly, are thus key regulators of adult bone mass.
Human epidermal growth factor receptor-2 expression and subsequent dynamic changes in patients with ovarian cancer
Authors: Kim Yoo-Na , Chung Yun Soo , Park Eunhyang , Lee Seung Tae , Lee Jung-Yun 
Published: April 2024

AbstractHuman epidermal growth factor receptor-2 (HER2)-targeting drugs are increasingly being incorporated into therapeutic paradigms for non-breast cancers, yet studies on HER2 expression in ovarian cancer (OC) are inadequate. Here, we studied the HER2 status and dynamic changes in OC by reviewing the records of patients who underwent HER2 testing at a single institution. Clinical parameters, including histology, BRCA status, and immunohistochemistry (IHC), were evaluated alongside HER2 expression, timing, and anatomical location. Among 200 patients, 28% and 6% exhibited expression scores of 2+ and 3+, respectively. HER2 3+ scores were observed in 23%, 11%, 9%, and 5% of mucinous, endometrioid, clear cell, and high-grade serous tumors, respectively, and were exclusively identified in BRCA-wildtype, mismatch repair-proficient, or PD-L1-low-expressing tumors. The TP53 mutation rate was low, whereas ARID1A, KRAS, and PIK3CA mutations were relatively more prevalent with HER2 scores of 2+ or 3+ than with 0 or 1+. Four of the five tumors with an HER2 3+ score exhibited ERBB2 amplification. Among 19 patients who underwent multiple time-lagged biopsies, 11 showed increased HER2 expression in subsequent biopsies. Patients with HER2-overexpressing OC exhibited distinct histological, IHC, and genomic profiles. HER2-targeting agents are potential options for BRCA-wildtype patients, particularly as later lines of treatment.
Comparison between using inlet circular jet and elliptic jet in combustion chamber by using twin jet flow propane and methanol
Authors: Yaseen Mohamed M. S. , Attia Ahmed A. , El-Dosouky M. W. , Hegazy Maher Gamil , Elsemary Ismail M. M. 
Published: April 2024

AbstractThe current work aimed to improve the combustion behavior of a non-premixed twin-jet inlet. The effect of fuel and air inlet shape under different velocities was studied using ANSYS as the process takes place in species transport and finite rate/eddy dissipation, and the flow is considered to be turbulent. Two different shapes (circular–circular and circular–elliptic inlet jets) were investigated, and the results show that the behavior and intensity of the fire are affected by variations in the speed and, geometry of the inlet which affects temperature, heat release rate, combustion efficiency, and equivalent ratios. The optimum air/fuel velocities were found to be 2.5/1.5 with circular–circular inlet jets.
Prognostic value of the combination of volume, massiveness and fragmentation parameters measured on baseline FDG pet in high-burden follicular lymphoma
Authors: Draye-Carbonnier S. , Camus V. , Becker S. , Tonnelet D. , Lévêque E. , Zduniak A. , Jardin F. , Tilly H. , Vera P. , Decazes P. 
Published: April 2024

AbstractThe prognostic value of radiomic quantitative features measured on pre-treatment 18F-FDG PET/CT was investigated in patients with follicular lymphoma (FL). We conducted a retrospective study of 126 FL patients (grade 1-3a) diagnosed between 2006 and 2020. A dozen of PET/CT-derived features were extracted via a software (Oncometer3D) from baseline 18F-FDG PET/CT images. The receiver operating characteristic (ROC) curve, Kaplan–Meier method and Cox analysis were used to assess the prognostic factors for progression of disease within 24 months (POD24) and progression-free survival at 24 months. Four different clusters were identified among the twelve PET parameters analyzed: activity, tumor burden, fragmentation-massiveness and dispersion. On ROC analyses, TMTV, the total metabolic tumor volume, had the highest AUC (0.734) followed by medPCD, the median distance between the centroid of the tumors and their periphery (AUC: 0.733). Patients with high TMTV (HR = 4.341; p < 0.001), high Tumor Volume Surface Ratio (TVSR) (HR = 3.204; p < 0.003) and high medPCD (HR = 4.507; p < 0.001) had significantly worse prognosis in both Kaplan–Meier and Cox univariate analyses. Furthermore, a synergistic effect was observed in Kaplan–Meier and Cox analyses combining these three PET/CT-derived parameters (HR = 12.562; p < 0.001). Having two or three high parameters among TMTV, TVSR and medPCD was able to predict POD24 status with a specificity of 68% and a sensitivity of 75%. TMTV, TVSR and baseline medPCD are strong prognostic factors in FL and their combination better predicts disease prognosis.
Modified polymeric biomaterials with antimicrobial and immunomodulating properties
Authors: Szałapata Katarzyna , Pięt Mateusz , Kasela Martyna , Grąz Marcin , Kapral-Piotrowska Justyna , Mordzińska-Rak Aleksandra , Samorek Elżbieta , Pieniądz Paulina , Polak Jolanta , Osińska-Jaroszuk Monika , Paduch Roman , Pawlikowska-Pawlęga Bożena , Malm Anna , Jarosz-Wilkołazka Anna 
Published: April 2024

AbstractThe modification of the surgical polypropylene mesh and the polytetrafluoroethylene vascular prosthesis with cecropin A (small peptide) and puromycin (aminonucleoside) yielded very stable preparations of modified biomaterials. The main emphasis was placed on analyses of their antimicrobial activity and potential immunomodulatory and non-cytotoxic properties towards the CCD841 CoTr model cell line. Cecropin A did not significantly affect the viability or proliferation of the CCD 841 CoTr cells, regardless of its soluble or immobilized form. In contrast, puromycin did not induce a significant decrease in the cell viability or proliferation in the immobilized form but significantly decreased cell viability and proliferation when administered in the soluble form. The covalent immobilization of these two molecules on the surface of biomaterials resulted in stable preparations that were able to inhibit the multiplication of Staphylococcus aureus and S. epidermidis strains. It was also found that the preparations induced the production of cytokines involved in antibacterial protection mechanisms and stimulated the immune response. The key regulator of this activity may be related to TLR4, a receptor recognizing bacterial LPS. In the present study, these factors were produced not only in the conditions of LPS stimulation but also in the absence of LPS, which indicates that cecropin A- and puromycin-modified biomaterials may upregulate pathways leading to humoral antibacterial immune response.
Advanced efficient energy management strategy based on state machine control for multi-sources PV-PEMFC-batteries system
Authors: Kanouni Badreddine , Badoud Abd Essalam , Mekhilef Saad , Bajaj Mohit , Zaitsev Ievgen 
Published: April 2024

AbstractThis article offers a PV-PEMFC-batteries energy management strategy (EMS) that aims to meet the following goals: keep the DC link steady at the standard value, increase battery lifespan, and meet power demand. The suggested multi-source renewable system (MSRS) is made to meet load demand while using extra power to fill batteries. The major energy source for the MSRS is photovoltaic, and fuzzy logic MPPT is used to guarantee that the PV operates at optimal efficiency under a variety of irradiation conditions. The suggested state machine control consists of 15 steps. It prioritizes the proton exchange membrane fuel cell (PEMFC) as a secondary source for charging the battery when power is abundant and the state of charge (SOC) is low. The MSRS is made feasible by meticulously coordinating control and power management. The MSRS is made achievable by carefully orchestrated control and electricity management. The efficacy of the proposed system was evaluated under different solar irradiance and load conditions. The study demonstrates that implementing the SMC led to an average improvement of 2.3% in the overall efficiency of the system when compared to conventional control techniques. The maximum efficiency was observed when the system was operating under high load conditions, specifically when the state of charge (SOC) was greater than the maximum state of charge (SOCmax). The average efficiency achieved under these conditions was 97.2%. In addition, the MSRS successfully maintained power supply to the load for long durations, achieving an average sustained power of 96.5% over a period of 7.5 s. The validity of the modeling and management techniques mentioned in this study are confirmed by simulation results utilizing the MATLAB/Simulink (version: 2016, link: https://in.mathworks.com/products/simulink.html) software tools. These findings show that the proposed SMC is effective at managing energy resources in MSRS, resulting in improved system efficiency and reliability.
Impact of sand media continuous drying and rewetting cyclic on nutrients transformation performance from reclaimed wastewater effluent at soil aquifer treatment
Authors: Gharbia Abdalkarim S. , Zákányi Balázs , Tóth Márton 
Published: April 2024

AbstractReusing reclaimed wastewater became a practical resource for water utilization in groundwater recharge and irrigation activities. However, the quality of reclaimed wastewater needs improvement to meet the environmental regulations and reduce contamination risks. A laboratory-scale study simulated a soil aquifer treatment (SAT) system, exploring the synergistic effects of wet and dry cycles alongside key physicochemical parameters on pollutant removal efficiency using a glass column filled with quartz sand as the filtration medium. The investigation focused on the cyclic wetting and drying phases to unravel their impact on removing NH4+, NO3−, and PO43−. The synthetic wastewater introduced into the system exhibited varying pollutant concentrations during wet and dry periods, influenced by dynamic soil water content (WC%), pH, dissolved oxygen (DO), and oxidation–reduction potential (ORP). The high removal rates of 93% for PO43− and 43% for Total N2 demonstrate the system’s capability to reduce concentrations significantly under dynamic alternating between wet and dry conditions. Results unveiled that the wet period consistently yielded higher removal rates for N2 species. Interestingly, for PO43−, the dry periods demonstrated a higher removal efficiency. Moreover, the study identified an average NO3− production during the experimental phases as a byproduct of nitrification. The average NO3− production in wet periods was 2.5 mg/L, whereas it slightly decreased to 2.2 mg/L in dry periods. These findings underscore the nuanced influence of wet and dry conditions on specific pollutants within SAT systems. Applying the logistic regression model and principal component analysis demonstrated the statistical significance of WC, pH, DO, and ORP in predicting wet/dry conditions, providing quantitative insights into their influential roles on the nutrient dynamic concentrations. This study contributes valuable data to our understanding of SAT systems, offering practical implications for designing and implementing sustainable wastewater treatment practices and pollution management across diverse environmental contexts.
Social and economic driving forces of recent CO2 emissions in three major BRICS economies
Authors: Koilakou Eleni , Hatzigeorgiou Emmanouil , Bithas Kostas 
Published: April 2024

AbstractThe study examines the driving factors of total energy-related and power-related (electricity-heat) CO2 emissions for China, India and Brazil, three BRICS countries with vital economic and demographic dynamics. The paper applies decoupling and decomposition analysis in order to investigate the influence of those factors that are prominent in the contemporary literature as well as factors reflecting important social and demographic dynamics which affect the ecological footprint of society. Household size and number of households are introduced into the relevant literature for the first time to reflect demographic factors with substantially different trends from population size, the predominant factor in the existing literature. This novelty together with the simultaneous application of decoupling and decomposition analysis adds importance to the findings of the study, which covers the period of 2000–2018. The results show that increasing income and population significantly enlarge the energy-related CO2 emissions. Household size, number of households and income effects are crucial in the increase of power-related CO2 emissions. The crucial factor for the decrease of energy-related CO2 emissions is the decreasing energy intensity, while for power-related CO2 emissions it is the emission factor effect reflecting the recent shift towards less carbon intensive energy types.
In the Driver's Seat: Narrative-Based Counseling in Aphasia
Authors: Lavergne Nicole , Azios Jamie H. , Azios Michael , Whisenhunt Saar Karen 
Published: April 2024

Purpose:
People with aphasia have been shown to experience higher rates of depression and mental health issues than stroke survivors without aphasia. Narrative-based counseling approaches to therapy in communication disorders have shown promise in several areas, such as stuttering. Little is known regarding how these approaches can be implemented with individuals with aphasia. This study sought to uncover what therapeutic processes could be utilized to overcome barriers to utilizing this approach with people with aphasia.

Method:
A qualitative case study design was utilized. The primary data source included audio-recorded intervention sessions of a narrative-based counseling approach. Secondary data sources included reflection journals produced by the clinician and artifacts created by the client, including letter written as a part of the therapeutic process and other documents co-constructed by the clinician and client that detailed the client's journey. Data were analyzed inductively, in which transcripts were coded by the researchers and compared across the data set until patterns were apparent in the data that were later defined as themes.

Results:
Analysis of data suggests that adapting narrative counseling techniques for success with people with aphasia consists of allowing adequate time for client response, building a therapeutic alliance, reiteration and saturation of solution-focused language and narratives, and maintaining a topic of conversation centered around aphasia.

Conclusion:
This study argues for further consideration of how narrative-based counseling techniques can be adapted and flexibly used in aphasia intervention.
Design of fractional MOIF and MOPIF controller using PSO algorithm for the stabilization of an inverted pendulum‐cart system
Authors: Cheballah Fatima , Mellah Rabah , Saim Abdelhakim 
Published: April 2024

AbstractThe topic of this paper is the design of two fractional order schemes, based on a state feedback for linear integer order system. In the first one of the state feedback is associated with a fractional order integral () controller. In the second structure the state feedback is associated with a fractional order proportional integral () controller. With such controllers, the closed loop system with state feedback described by the state equations splits in n‐subsystems with different fractional orders derivatives of the state variable. In order to find the optimal parameters value of both controllers () and (), a multi‐objective particle swarm optimization algorithm is used, with the integral of absolute error, the overshoot , the Buslowicz stability criterion are considered as objective functions. The multi‐objective integral fractional order controller and the multi‐objective proportional integral fractional order controller are applied to stabilize the inverted pendulum‐cart system (IP‐C), and their performance is compared to the fractional order controller. The simulation results of these innovative controllers are also compared with those obtained by conventional proportional–integral–derivative and fractional order proportional–integral–derivative controllers. The robustness of the proposed controllers against disturbances is investigated through simulation runs, considering the non‐linear model of the IP‐C system. The obtained results demonstrate that our approach not only leads to high effectiveness but also showcases remarkable robustness, supported by both simulation and experimental results.
Fault‐tolerant control of current residual vector three‐phase four‐switch motor drive system based on MLD model
Authors: Chen Dezhi , Zhao Wenbo , Sun Yun , Zhao Wenliang , Zhang Zhixiang , Xin Ziyuan 
Published: April 2024

AbstractAiming at the problem of single‐phase switch tube open circuit fault in inverters, a current residual vector three‐phase four‐switch fault‐tolerant control strategy based on the mixed logic dynamic (MLD) model of permanent magnet synchronous motor (PMSM) drive system is proposed. Firstly, the MLD and three‐phase four‐switch mathematical models of the motor drive system are established and a calculation method of DC bus capacitance is proposed. Secondly, to improve the dynamic performance of the motor, an improved vector control based on the MLD model is proposed. Finally, by setting the threshold and dividing the area of the current residual vector, the accuracy of inverter fault diagnosis is improved, and the fast and smooth switching of the drive system after the fault is realized. Simulation and experimental results show that this strategy can effectively reduce the influence of calculation error and system noise, and has strong robustness for the change of motor speed and load.
Smart binary phase‐coding for pulse‐compression radar: An electronic protection technique against repeater jamming
Authors: Yıldırım Alper , Kiranyaz Serkan 
Published: April 2024

AbstractNowadays, modern radar systems increase their target detection capabilities by processing pulses coherently. On the other hand, digital radio frequency memory‐based modern jammers have the ability to work coherently and can deceive radars even with a very low effective radiated power. These jammers, which have the capability of storing the radar's pulse, can use the previous pulses that they have stored in their memory during the electronic deception, without waiting for the last pulse of the radar, in other words, before the new pulse is received. If the radar does not change its parameters from pulse to pulse, such smart jamming techniques applied in this way can be very effective. In this article, the authors propose to use a smart binary phase‐coding method for pulse compression radar as an electronic protection technique against repeater jamming. This approach further improves the target detection capability of modern radar systems, which use coherent integration in the receiver. The proposed method can provide high protection against digital radio frequency memory‐based repetitive range deception techniques without compromising the radar's target detection capability. In the simulations, the traditional approach in which the same code is used without changing from pulse‐to‐pulse, and the approach using code sets obtained by the smart binary phase‐coding method in intra‐pulse modulation are compared. The results show that the proposed method can significantly improve the isolation against deception jamming and the target detection capability simultaneously.
Association between endoscopist adenoma detection rate and serrated polyp detection: Retrospective analysis of over 200,000 screening colonoscopies
Authors: Penz Daniela , Pammer Daniel , Waldmann Elisabeth , Asaturi Arno , Szymanska Aleksrandra , Trauner Michael , Ferlitsch Monika 
Published: April 2024

Abstract
Background and study aims Serrated lesions have been identified as precursor lesions for 20% to 35% of colorectal cancers (CRCs) and may contribute to a significant proportion of interval-cancer. Sessile-serrated-lesions (SSLs), in particular, tend to be flat and located in the proximal colon, making their detection challenging and requiring expertise. It remains unclear whether the detection rate for serrated polyps should be considered as a quality indicator in addition to the adenoma detection rate (ADR). This study sought to assess whether the ADR has an effect on the detection rate for serrated polyps.
atients and methods In this retrospective analysis, prospectively collected data from 212,668 screening colonoscopies performed between 2012 and September 2018 were included. Spearman correlation and Whitney-Mann U-test were used to assess the association of ADR and the detection rate of SSLs with (SDR) and without hyperplastic polyps (SPADRs), the sessile serrated detection rate (SSLDR) as well as the clinically relevant serrated detection rate (CRSDR), including all SSLs and traditional serrated adenoma, hyperplastic polyps (HPs) >10 mm anywhere in the colon or HPs > 5 mm proximal to the sigmoid.
Results The overall mean ADR was 21.78% (standard deviation [SD] 9.27), SDR 21.08% (SD 11.44), SPADR 2.19% (SD 2.49), and CRSDR was 3.81% (3.40). Significant correlations were found between the ADR and the SDR, SPADR, SSLDR, and CRSDR (rho=0.73 vs. rho=0.51 vs. rho=0.51 vs. rho=0.63; all P <0.001). Endoscopists with a mean ADR ≥25% had significantly higher SDR, SPADR, and CRSDR than endoscopists with a mean ADR <25% (all P <0.001; Mann-Whitney U-Test).
Conclusions This study shows that endoscopists with higher ADR detect significantly more serrated lesions than those with a lower ADR.