bluuebunny/crossref_metadata_2025_split huggingface dataset:
Legal Antinomy in Exercising Civil Rights of Persons with Disabilities in Notarial Activities
Authors: Sendrawan Tjhong , Agustina Rosa , Makarim Edmon 
Published: February 2025

This paper addresses the legal antinomy present in the exercise of civil rights for persons with disabilities (PWD) in notarial activities in Indonesia. The conflict arises between the need for legal certainty, as required by national laws, and the obligation to provide equal justice and access for PWD, as mandated by the Convention on the Rights of Persons with Disabilities (CRPD). Key provisions of the Indonesian Notary Law, particularly the Notary Law Amendment of 2014, impose barriers that hinder PWD from fully exercising their civil rights. These issues highlight the lack of clear guidelines for notaries in accommodating PWD, resulting in legal uncertainty and potential discrimination. This paper proposes legal reforms and emphasizes the need for notaries to act as facilitators of justice, ensuring equal access to civil rights for PWD in line with international human rights standards.The study employs doctrinal legal research methods, through literature reviews collected from various primary, secondary and tertiary legal materials, such as international convention, notary laws, books, journals, dictionaries and research papers published relevant to the topic. This article limits the analysis of human rights of PWD in accessing their civil rights services provided by a Notary. Notary needs to understand and carefully make legal judgment in providing advices and drawing up notarial acts with various kinds of circumstances involving disabilities. In the end, this paper acknowledges a significant finding that Article 16 paragraph 1 letter (c), Article 42 paragraph (2) and paragraph (3), Article 43 paragraph (3) of the Notary Law Amendment of 2014 currently hinder the exercise of civil rights of PWD. This article contributes both theoretically and empirically contribution to the ongoing discussion and presents perspectives from the Indonesian Constitutional Court Judgement Number 93/PUU-XX/2022, which amends the provisions of Article 433 Indonesian Civil Code and argues for the importance of a specific understanding and guidelines on this issue.
Thessaly Graft Index
Authors: Chalatsis Georgios , Siouras Athanasios , Mitrousias Vasileios , Chantes Ilias , Moustakidis Serafeim , Tsaopoulos Dimitris , Vlychou Marianna , Tasoulis Sotiris , Hantes Michael 
Published: February 2025

Background:
Magnetic resonance imaging (MRI) has proven to be a valuable noninvasive tool to evaluate graft integrity after anterior cruciate ligament (ACL) reconstruction. However, MRI protocols and interpretation methodologies are quite diverse, preventing comparisons of signal intensity across subsequent scans and independent investigations. The purpose of this study was to create an artificial intelligence (AI)-based index (Thessaly Graft Index [TGI]) for the evaluation of graft integrity following ACL reconstruction.

Methods:
The cohort study included 24 patients with an isolated ACL injury that had been treated with a hamstring tendon autograft and followed for 1 year. MRI was performed preoperatively and 1 year postoperatively. The clinical and functional evaluations were performed with use of the KT-1000 and with the following patient-reported outcome measures (PROMs): the Knee Injury and Osteoarthritis Outcome Score (KOOS), the International Knee Documentation Committee Subjective Knee Function form (IKDC), the Lysholm score, and the Tegner Activity Scale (TAS). An AI model, based on the YOLOv5 Nano version, was designed to compute the probability of accurately detecting, in the sagittal plane, a healthy ACL (on a percentage scale) and was trained on healthy and injured knees from the KneeMRI dataset. The model was used to assess the integrity of ACL grafts, with a maximum score of 100. The results were compared with the MRI assessment from an independent radiologist and were correlated with PROMs and KT-1000 laxity.

Results:
The mean preoperative and postoperative TGI scores were 64.21 ± 8.96 and 82.37 ± 3.53, respectively. A mean increase of 15% in the TGI scores was observed between preoperative and postoperative images. The minimum threshold for TGI to categorize a graft as healthy on the postoperative MRI was 79.21%. Twenty-two grafts were characterized as intact and 2 as reruptured, with postoperative TGI scores of 71% and 42%. The radiologist’s assessment was in total agreement with the TGI scores. The correlation of the TGI ranged from moderate to good with the TAS (0.668), IKDC (0.516), Lysholm (0.521), KOOS total (0.594), and KT-1000 (0.561).

Conclusions:
The TGI is an AI tool that is able to accurately recognize an ACL graft rupture. Moreover, the TGI correlated with the KT-1000 postoperative values and PROM scores.

Level of Evidence:
Diagnostic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Coal Mine Hidden Disaster Detection Based on Opposing Coils Transient Electromagnetic Method
Authors: Xiao Jian , Han Shili , Duan Xianzhe , Zhao Pengtao , Shen Guangjun , Xie Yanshi , He Haiyang , Deng Zixiang , Liu Wei , Yan Yueping 
Published: February 2025

Abstract
Hidden water disasters seriously affect the construction safety of coal mines and the life safety of technicians. In order to find out the spatial distribution of air-filled goaf and water-filled goaf in coal mines, opposing coils transient electromagnetic method (OCTEM) with high detection accuracy, high resolution, high sensitivity to abnormal bodies, and fast detection speed is used to carry out research. Through field data acquisition and inversion processing, the inversion profile, slice map, and three-dimensional shape rendering map of each survey line are obtained, and then the geological data are analyzed and explained. Finally, two low-resistance anomaly areas are delineated. One is speculated to be the old kiln goaf, and the other is speculated to be the water-filled goaf in the planning area in the next 5 years. After drilling verification, the speculation results are in good agreement with the actual situation. OCTEM provides an innovative technical basis for the detection of hidden hazards in mines, which has broad application potential in the field of mine exploration.
Restructuring knowledge graphs with conceptual models: implications for machine learning predictions in drug repurposing
Authors: Bernabé César , Zwart Rosa , Perdomo-Quinteiro Pablo , Jacobsen Annika , Sales Tiago Prince , Queralt-Rosinach Núria , Wolstencroft Katherine , Santos Luiz Olavo Bonino da Silva , Mons Barend , Roos Marco 
Published: February 2025

Abstract

This paper investigates the impact of restructuring knowl- edge graphs (KGs) with well-founded conceptual models to improve ma- chine learning (ML) predictions, particularly in drug repurposing appli- cations. These conceptual models were developed using OntoUML, which is grounded in the Unified Foundational Ontology, and were constructed following an established workflow for data FAIRification–a process aimed at making data more Findable, Accessible, Interoperable, and Reusable. We compared the performance of a Graph Neural Network model trained on original public KGs with models trained on the same restructured KGs. Our results indicate that while the ML model classification perfor- mance (measured in terms of accuracy and error metrics) remains similar for both, the models trained on restructured KGs produce more consis- tent predictions, reducing variability across multiple runs. These findings suggest that restructuring KGs using well-founded conceptual models can enhance the reliability of ML predictions without compromising model performance. We conclude by proposing future research directions to fur- ther explore the potential of conceptual models and FAIR principles in improving ML.
2D PbS Quantum Dot Superlattices with Unprecedented Area Coverage and Homogeneity via Langmuir-Schaefer Deposition
Authors: Loi Maria Antonietta , Pinna Jacopo , Mednicov Alexandru , Koushki Razieh Mehrabi , Ahmadi Majid , Ruiz-Franco José , Giuntoli Andrea , Kooi Bart , Portale Giuseppe 
Published: February 2025

Abstract

Superlattices of lead chalcogenide colloidal quantum dots hold promise to revolutionise the field of infrared optoelectronics due to their unique combination of optical and transport properties. However, the main challenge remains to form a homogeneous thin-film with long-range order avoiding cracking upon ligand exchange. This problem is particularly evident in 2D superlattices where the interactions driving the self-assembly are limited to a single plane yielding very defective films. To overcome these issues, we introduce a novel approach where external lateral pressure is applied during the self-assembly and ligand exchange, forcing the quantum dots toward each other thus avoiding the formation of cracks due to the volume shrinking. Such films consist of a hexagonal monolayer superlattice with long-range order that are crack-free over several millimetres square. The mechanism beyond the formation and ordering of the samples under external pressure is elucidated by atomistic molecular dynamic simulations. Transport measurements in an ionic gel-gated field-effect transistor reveal that increasing the external pressure during the superlattice formation leads to higher electron mobilities above 25 cm2/Vs thanks to better compactness, high ordering, and a higher number of nearest neighbours. These results demonstrate that colloidal quantum dot superlattices with high charge mobility can be fabricated over large areas with important implications for technological applications.
Knowledge, Awareness, and Practices regarding climate change among undergraduate students.
Authors: Rabbi Rifat Hasan 
Published: February 2025

Abstract

The undergraduate students' knowledge, perception, and practices regarding climate change in the Department of Agricultural Science at Daffodil International University, Bangladesh, were studied. In total, 150 students were surveyed in a cross-sectional study using a structured questionnaire. This paper will highlight the level of understanding that the students have with regard to causes, impacts, and mitigation strategies related to climate change, and their involvement in climate-friendly practices. Results show a high overall awareness of 86% on climate change, while 80.67% perceive manifestations within their communities. Students also showed good knowledge in the causes of climate change, with the burning of fossil fuel at 68.6% and deforestation at 68.0% being the most mentioned causes. On the impact, sea-level rise at 78.6% is most identified, closely followed by desertification at 78.0%. These are practical mitigation measures, and the response was very overwhelming for: reduction of industrial pollution with 82% agreeing, adoption of renewable energy with 81.3% agreeing. The analysis of climate-friendly practices indicated that the highest engagement in tree planting stood at 82.6%, while water conservation was at 82%. There is a weak positive correlation between knowledge about climate change and mitigation practices, as the correlation coefficient was very small (r = 0.057, p = 0.495), signifying that with more knowledge, more action is not necessarily taken. Chi-square tests indicated no statistically significant associations of gender or academic level with knowledge of climate change.
Screening of colorectal cancer by a fecal gas compound analysis
Authors: Ishibe Atsushi , Watanabe Jun , Yamakoshi Hideki , Yamagishi Shigeru , Goto Koki , Suwa Yusuke , Nakagawa Kazuya , Ozawa Mayumi , Saigusa Yusuke , Kunisaki Chikara , Endo Itaru 
Published: February 2025

Abstract

BACKGROUND
Colorectal cancer (CRC) remains a significant cause of mortality worldwide. Although FOBT has demonstrated efficacy in reducing colorectal cancer-related deaths, it has limitations. We explored an innovative and user-friendly screening method using gas sensors installed in toilets.
METHODS
We developed gas sensors that can be installed in toilets. We conducted a demonstration experiment using these sensors to monitor individuals in their bathrooms. The experiment involved 101 colorectal cancer (CRC) patients, 50 colorectal polyp patients, and 90 healthy individuals who were registered and monitored for a week at home. Gas data collected during defecation were analyzed to assess the feasibility of colorectal cancer screening.
RESULTS
Age and sulfur-containing gas, CH4, and CO2 content were significantly higher in the CRC group than in the non-CRC group in a univariate analysis. The area under the receiver operating characteristic curve of the discriminant formula for diagnosing colorectal cancer was 0.859.
CONCLUSION
A sensor analysis of defecation gas constitutes a promising, novel, and non-invasive approach for CRC screening.
Do we cause dysphagia when treating spasmodic dysphonia with botox?
Authors: Altan Esma 
Published: February 2025

Abstract

Objectives: Spasmodic dysphonia (SD) is a neurological movement disorder involving the laryngeal muscles. There are three main types: adductor, abductor and mixed type. adductor type is the most common and mixed type is the rarest. Botox is the gold standard in treatment, botox is applied to the affected muscle group according to the type of spasmodic dysphonia. Dysphagia often occurs as a side effect of treatment (botulinum toxin injection) in spasmodic dystonia. Sometimes dysphagia may be seen secondary to spasmodic dysphonia.
Methods: This study included 8 patients with adductor spasmodic dysphonia and 8 without dysphagia and 8 healthy subjects. Swallowing evaluation of both groups was performed by FEES, EMG and ultrasound.
Results:Swallowing functions of patients with adductor spasmodic dysphonia were re-evaluated after botox injection into the thyroarytenoid muscle. No significant difference was observed in both groups
Conclusion: In our study, our patient group consisted of patients with spasmodic dysphonia without dysphagia and dysphagia was not observed in patients evaluated with FEES, EMG and ultrasound after Botox.
Case report: contamination of a drinking water distribution system by Exophiala-dominated biofilm in the Midwestern United States
Authors: King Jon C. , Lancaster Emma , Myers Alicia , Lee Jiyoung , Dannemiller Karen C. 
Published: February 2025

ABSTRACT

Fungal contamination of drinking water distribution systems can impact water quality with implications for public health. We document an instance of Exophiala spp. biofilm contamination of customer taps in the Midwest United States following consumer complaints. Three samples of black biofilm were collected from customer taps in Ohio and then processed using next-generation DNA sequencing of the bacterial 16S and fungal ITS regions. Two samples with successful ITS sequencing were dominated by Exophiala spp., putatively identified as E. cancerae and E. lecanii-corni. Dominant bacterial phyla in samples included Proteobacteria, Bacteroidetes, Actinobacteria, and Acidobacteria. Bacterial composition varied substantially at the family and genus levels, and potentially pathogenic bacteria (i.e., Acinetobacter spp., Legionella spp., Mycobacterium spp., and Pseudomonas spp.) were detected. The potential for fungal contamination of drinking water distribution systems should be evaluated when biofilms are observed.
Evaluating the Chemical Characteristics of Wash-off Fine Particulate
Matter from Leaves of Woody Plants in Budapest
Authors: Chen Haimei , Szabó Veronika , Kardos Levente 
Published: February 2025

Background:
Particulate matter poses a significant risk to human health, particularly fine
particulate matter, as it is difficult to eliminate and leads to severe health issues. Conversely, urban
woody plants are experiencing ambient pollution directly and continuously adjusting to the dynamic
contaminants, thereby improving the urban environment for their living circumstances. Thus, studies
conducted at the level of individual leaves can offer important insights into the productivity of an
ecosystem

Method:
Leaf samples from three common woody plant species (Acer platanoides, Fraxinus excelsior, and Tilia tomentosa) in Budapest, Hungary, were collected throughout a vegetation phase. After
ultrasonic wash-off, the chemical properties of dust deposits on the leaf surface were investigated.

Results:
Our results showed a higher concentration of wash-off fine particulate from F. excelsior
than from A. platanoides and T. tomentosa, and the precipitation, maximum wind speed, and ambient
particulate matter content did not demonstrate a significant impact on it. Thus, the fine particulate
matter washed off from woody plant leaves involves a more dynamic and complex procedure. The
analysis of chemical parameters demonstrated the interaction of particulate matter and the leaves; pH
values varied, and the total electric conductivity was significantly higher than the accepted limits.
The excessive concentration of sulphate and chloride in wash-off particulate matter indicated significant interference caused by human activities and secondary suspension.

Conclusion:
Given that F. excelsior is more susceptible to having wash-off fine particulate matter,
which can contribute to secondary suspension, the capability of A. platanoides and T. tomentosa to
retain fine particulate may contribute to their effects in phytoremediation.
A Systematic Quantitative Approach to Rational Drug Design and the Discovery of
Novel Human Antigen R (HuR) Inhibitors
Authors: Dey Juhi , Kaushiki Kumari , Mishra KM Abha , Sudheer Paga , Sethi Kalyan Kumar 
Published: February 2025

Background:
1,4-Naphthoquinone and its derivatives are recognized for their potent anticancer effects,
establishing this pharmacophore as a key focus in cancer research. Their potential to modulate cellular pathways
suggests they could be effective in developing new HuR inhibitors, targeting a protein crucial for regulating cancer-related gene expression. Compounds C1-C20 were designed by using Discovery Studio (DS) software.

Methods:
In this study, a systematic approach involves scaffold hopping followed by additional research such as
molecular docking, ADMET, drug-likeness, toxicity prediction, molecular dynamic (MD) simulation, and binding free energy analysis was used to discover novel Human Antigen R (HuR) inhibitors.

Results:
In molecular docking, 1,4-Naphthoquinone derivatives showed better interactions with the HuR protein
compared to that of the conventional HuR inhibitor MS-444. Among twenty 1,4-Naphthoquinone derivatives,
most of the compounds showed favorable pharmacokinetic characteristics. In the toxicity prediction model, most
of the designed compounds were neither mutagenic nor carcinogenic. According to MD simulation, C5 is more
stable than MS-444.

Conclusion:
The designed 1,4-Naphthoquinone derivatives have been found to be crucial structural motifs for the
discovery of novel HuR inhibitors, which was well supported by the in-silico screening and molecular modeling
methods.
Cancer Therapy with Polymeric Nanocarriers and the Transition to Targeted Cancer Therapy: Advances and Future Directions
Authors: Theodosis-Nobelos Panagiotis , Kitiri Elina N. , Christou Melina , Pantelidou Maria , Rikkou-Kalourkoti Maria 
Published: February 2025

Abstract:
The development of targeted cancer therapies has become crucial in addressing the limitations
of conventional chemotherapy, particularly its lack of specificity and severe side effects.
Polymeric nanocarriers have emerged as a transformative solution, providing enhanced drug solubility,
selective targeting, and controlled release of therapeutics. This review discusses recent advances
in polymeric nanocarriers, emphasizing their capacity to incorporate multiple drugs and optimize
delivery through both active and passive targeting strategies, and especially the transition to
targeted cancer therapy through the various applied methods in the field. Mechanisms such as the
enhanced permeability and retention (EPR) effect for passive targeting, and the use of ligands, peptides,
and proteins for active targeting, are explored in depth. Furthermore, the potential of these
nanocarriers to improve therapeutic outcomes through targeting specific cellular and subcellular
sites, including the nucleus, mitochondria, and endoplasmic reticulum, is examined. These innovations
pave the way for the development of safer and more effective cancer treatments with the potential
to enhance clinical outcomes.
Emotional Design Optimization of Memorial Space Based on Nomadic Theory
Authors: Zhu Jie , Liu Jiaqi 
Published: February 2025

Memorials bear the responsibility of popularizing cultural knowledge and promoting the spirit of patriotism. In recent years, due to the increasing support of the government for memorials, there are more and more memorials, and they have gradually received widespread attention from the whole society. However, with the development of the digital age, the public pays more and more attention to user experience. In today's information age, the main narrative methods of text and images have exposed the weakness of the emotional expression of memorial space. Based on the nomadic theory, this paper takes contemporary memorials as the research object, adopts literature research method, case analysis method and comparative analysis method, transforms the idea of nomadic space into the design of contemporary memorial space, combines emotional design techniques, breaks the traditional spatial boundaries, and forms a multi-dimensional dynamic space, which can reshape the experience of memorials and return to the core of space, that is, human experience, and provide new methods and inspiration for the spatial design of contemporary memorials.
Estimating Normal and Tangential Forces in Tires through Ionic Liquid-Based Flexible Sensors
Authors: Hossain Md Jarir , Mouna Shahba Tasmiya , Choi Jae-Won 
Published: February 2025

ABSTRACT
Measuring normal and tangential forces on tires is crucial for enhancing tire performance under various road conditions and environmental settings. The measurement of these forces has been challenging because of limitations in sensing technology related to rigidity, durability, and sensitivity. This research introduces an innovative method that utilizes flexible sensors made of ionic liquid to address the limitations. Through the utilization of the distinctive properties of ionic liquids, such as their flexibility, enhanced sensitivity, and exceptional stability, a multilayer sensor has been manufactured. This sensor consists of carbon nanotube electrodes, ionic liquid dispersed in polymer creating a pressure-sensitive layer, and polymer insulating layers. The focus of this study is on the development of the sensor and understanding how its output changes under varying normal and tangential forces. Preliminary testing has shown that the sensor exhibits distinct and measurable responses to both force components, highlighting its potential for accurate force differentiation. The research evaluates the sensor’s performance and efficacy under varied force conditions, demonstrating its capability to accurately measure both normal and tangential forces. Such measurements are vital for the development of intelligent tires, offering deeper insights into critical tire parameters such as braking or traction force coefficients, contact patch characteristics, vehicle dynamics, and road surface conditions, leading to the improvement of safety, efficiency, and performance of tires.