bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ambivalent images of birth in Psalm vii 15
Authors: Grohmann Marianne 
Published: November 2005

AbstractIn this article Psalm vii 15 is analysed by means of close reading, interaction theories of metaphor and a reader-oriented approach, including Jewish medieval commentaries. The very fabric of Psalm vii 15 is made up of the tension between the constructive image of birth and the destructive aspects of the wicked. The verse does not correspond to the expectations of the reader: e.g. the sequence of stages in the birth process is unusual: labour—pregnancy—birth; the birth process is described with masculine verbs, and it is not clear who the subject is. Ps. vii 15 is an example of the fact that concrete and abstract features often go together in biblical metaphors. The presentation of the enemies' negative features in personified images of birth makes them more drastic. It reduces the possible connotations of birth to its negative aspects. Using birth as a negative image, the text shows something of the ambivalence of birth.
Are Color Categories Innate or Internalized? Hypotheses and Implications
Authors: Bimler David 
Published: November 2005

AbstractThe considerable agreement across languages in the way they categorize the color domain, despite independent historical development, demands an explanation. One option is to postulate a universal innate representation of the color categories, 'hardwired' into each observer's brain. An alternative is that observers internalize their color categories through a process of cultural (linguistic) transmission, constrained by some kind of 'optimality hypothesis' to account for the cross-language agreement. A number of optimality hypotheses are reviewed. It is tempting to believe that the vivid experiential quality of the categories can only be explained if they are determined by innate representations rather than by linguistic imprinting. However, linguistic transmission of color categories – perturbed from their optimal boundaries by special circumstances – fits best with the experience of dichromats. Even for the 'primary hue' categories, where the case for innate representations should be strongest, the evidence is far from convincing.
Color, Color Terms, Categorization, Cognition, Culture: An Afterword
Authors: Dedrick Don 
Published: November 2005

AbstractRecent work on color naming challenges the idea that there are shared perceptually salient colors or color categories that are "hardwired" into homo sapiens and provide the basis for one of the most famous cross-cultural claims of all time, Brent Berlin and Paul Kay's claim that there is a small number of "basic" color terms (eleven), and that some subset of these terms is present in every human language (Berlin & Kay, 1969; see Kay and Maffi, 1999; Kay and Reiger, 2003; and Kay 2005 for updates).
The response of VEGF-stimulated endothelial cells to angiostatic molecules is substrate-dependent
Authors: Addison Christina L , Nör Jacques E , Zhao Huijun , Linn Stephanie A , Polverini Peter J , Delaney Christie E 
Published: November 2005

Abstract
Background
The microenvironment surrounding cells can exert multiple effects on their biological responses. In particular the extracellular matrix surrounding cells can profoundly influence their behavior. It has been shown that the extracellular matrix composition in tumors is vastly different than that found in normal tissue with increased amounts of certain matrices such as collagen I. It has been previously demonstrated that VEGF stimulation of endothelial cells growing on type I collagen results in the induction of bcl-2 expression and enhanced endothelial cell survival. We sought to investigate whether this increased endothelial cell survival resulted in the failure of angiostatic molecules to inhibit angiogenesis.

Results
We now demonstrate that VEGF-induced survival on collagen I impairs the ability of three known angiostatic molecules, TSP-1, IP-10 and endostatin to inhibit endothelial cell proliferation. Apoptosis of endothelial cells, growing on collagen I, induced by TSP-1 and IP-10 was also inhibited following VEGF stimulation. In contrast, endostatin induced apoptosis in these same cells. Further analysis determined that endostatin did not decrease the expression of bcl-2 nor did it increase activation of caspase-3 in the presence of VEGF. Alternatively, it appeared that in the presence of VEGF, endostatin induced the activation of caspase-8 in endothelial cells grown on collagen I. Furthermore, only endostatin had the ability to inhibit VEGF-induced sprout formation in collagen I gels.

Conclusion
These data suggest that TSP-1, IP-10 and endostatin inhibit endothelial cells via different mechanisms and that only endostatin is effective in inhibiting angiogenic activities in the presence of collagen I. Our results suggest that the efficacy of angiostatic treatments may be impaired depending on the context of the extracellular matrix within the tumor environment and thus could impede the efficacy of angiostatic therapies.
Analysis of four DLX homeobox genes in autistic probands
Authors: Hamilton Steven P , Woo Jonathan M , Carlson Elaine J , Ghanem Nöel , Ekker Marc , Rubenstein John LR 
Published: November 2005

AbstractBackgroundLinkage studies in autism have identified susceptibility loci on chromosomes 2q and 7q, regions containing the DLX1/2 and DLX5/6 bigene clusters. The DLX genes encode homeodomain transcription factors that control craniofacial patterning and differentiation and survival of forebrain inhibitory neurons. We investigated the role that sequence variants in DLX genes play in autism by in-depth resequencing of these genes in 161 autism probands from the AGRE collection.ResultsSequencing of exons, exon/intron boundaries and known enhancers of DLX1, 2, 5 and 6 identified several nonsynonymous variants in DLX2 and DLX5 and a variant in a DLX5/6intragenic enhancer. The nonsynonymous variants were detected in 4 of 95 families from which samples were sequenced. Two of these four SNPs were not observed in 378 undiagnosed samples from North American populations, while the remaining 2 were seen in one sample each.ConclusionSegregation of these variants in pedigrees did not generally support a contribution to autism susceptibility by these genes, although functional analyses may provide insight into the biological understanding of these important proteins.
Cerebrospinal fluid HIV infection and pleocytosis: Relation to systemic infection and antiretroviral treatment
Authors: Spudich Serena S , Nilsson Annelie C , Lollo Nicole D , Liegler Teri J , Petropoulos Christos J , Deeks Steven G , Paxinos Ellen E , Price Richard W 
Published: November 2005

Abstract

Background
Central nervous system (CNS) exposure to HIV is a universal facet of systemic infection. Because of its proximity to and shared barriers with the brain, cerebrospinal fluid (CSF) provides a useful window into and model of human CNS HIV infection.

Methods
Prospective study of the relationships of CSF to plasma HIV RNA, and the effects of: 1) progression of systemic infection, 2) CSF white blood cell (WBC) count, 3) antiretroviral therapy (ART), and 4) neurological performance. One hundred HIV-infected subjects were cross-sectionally studied, and 28 were followed longitudinally after initiating or changing ART.

Results
In cross-sectional analysis, HIV RNA levels were lower in CSF than plasma (median difference 1.30 log10 copies/mL). CSF HIV viral loads (VLs) correlated strongly with plasma VLs and CSF WBC counts. Higher CSF WBC counts associated with smaller differences between plasma and CSF HIV VL. CSF VL did not correlate with blood CD4 count, but CD4 counts <50 cells/μL associated with a low prevalence of CSF pleocytosis and large differences between plasma and CSF VL. CSF HIV RNA correlated neither with the severity of the AIDS dementia complex (ADC) nor abnormal quantitative neurological performance, although these measures were associated with depression of CD4 counts.
In subjects starting ART, those with lower CD4 counts had slower initial viral decay in CSF than in plasma. In all subjects, including five with persistent plasma viremia and four with new-onset ADC, CSF HIV eventually approached or reached the limit of viral detection and CSF pleocytosis resolved.

Conclusion
CSF HIV infection is common across the spectrum of infection and is directly related to CSF pleocytosis, though whether the latter is a response to or a contributing cause of CSF infection remains uncertain. Slowing in the rate of CSF response to ART compared to plasma as CD4 counts decline indicates a changing character of CSF infection with systemic immunological progression. Longer-term responses indicate that CSF infection generally responds well to ART, even in the face of systemic virological failure due to drug resistance. We present simple models to explain the differing relationships of CSF to plasma HIV in these settings.
Association of paternal age at birth and the risk of breast cancer in offspring: a case control study
Authors: Choi Ji-Yeob , Lee Kyoung-Mu , Park Sue Kyung , Noh Dong-Young , Ahn Sei-Hyun , Yoo Keun-Young , Kang Daehee 
Published: November 2005

Abstract

Background
Older paternal age may increase the germ cell mutation rate in the offspring. Maternal age may also mediate in utero exposure to pregnancy hormones in the offspring. To evaluate the association between paternal and maternal age at birth with the risk of breast cancer in female offspring, a case-control study was conducted in Korea.

Methods
Histologically confirmed breast cancer cases (n = 1,011) and controls (n = 1,011) with no present or previous history of cancer, matched on year of birth and menopausal status, were selected from several teaching hospitals and community in Seoul during 1995–2003. Information on paternal and maternal ages and other factors was collected by interviewed questionnaire. Odds ratio (OR) and 95% confidence interval (95% CI) were estimated by unconditional logistic regression model adjusting for family history of breast cancer in 1st or 2nd degree relatives, and lifetime estrogen exposure duration.

Results
The risk of breast cancer significantly increased as the paternal age increased (p for trend = 0.025). The association was stronger after controlling for maternal age; women whose fathers were aged ≥40 years at their birth had 1.6-fold increased risk of breast cancer compared with fathers aged <30 years. This association was profound in breast cancer cases in premenopausal women (OR = 1.9, 95% CI = 1.12–3.26, for paternal aged ≥40 vs. <30) (p for trend = 0.031). Although the risk of breast cancer increased as maternal age increased up to the intermediate, and then reduced; the risks in women whose mother were aged 25–29, 30–34, and ≥35 yrs at birth compared to women whose mothers were aged <25 years, were 1.2, 1.4, and 0.8, respectively, the trend was not significant (p for trend = 0.998).

Conclusion
These findings suggest that older paternal age increases the risk of breast cancer in their female offspring.
Back pain reporting in young girls appears to be puberty-related
Authors: Wedderkopp Niels , Bo Andersen Lars , Froberg Karsten , Leboeuf-Yde Charlotte 
Published: November 2005

Abstract

Background
There is a large increase in back pain reporting in the early teens. In no previous study has the prevalence of low back pain been investigated in relation to the onset of puberty. The objective of this study was to establish whether the onset of puberty is associated with back pain reporting in young girls.

Methods
A subsample of 254 girls aged 8–10 years and 165 girls aged 14–16 years from a cross-sectional survey of 481 children aged 8–10 years and 325 adolescents aged 14–16 years of both sexes.
Main outcome measures were back pain defined as low back pain, mid back pain, and/or neck pain in the past month.
Other variables of interest were Puberty (five different stages), age, body mass index, and smoking. Independent information on onset of puberty was obtained through a physical examination and on back pain through an individual structured interview. The association was studied between onset of puberty and the outcome variable (the one month period prevalence of back pain), controlling for overweight, and smoking. Odds ratios with 95% confidence intervals were used to describe bivariate associations, logistic regression with robust standard errors was used for multivariate analyses.

Results
There is a highly significant trend for increased back pain reporting with increasing level of puberty until maturity is reached. The biggest leap appears between the second level (beginning of puberty) and the third level (mid puberty) and the findings remain after controlling for the covariates. These results emanate from the low back, whereas pain in the mid back and neck do not seem to be linked with pubertal stage.

Conclusion
In girls, the reporting of low back pain increases in frequency during puberty until maturity, regardless of age. Why some girls are susceptible to back pain in the early stage of puberty is unknown.
Association between lifestyle factors and plasma adiponectin levels in Japanese men
Authors: Tsukinoki Rumi , Morimoto Kanehisa , Nakayama Kunio 
Published: November 2005

Abstract

Background
Adiponectin is an adipocyte-specific protein that plays a role in obesity, insulin resistant, lipid metabolism, and anti-inflammation. Hypoadiponectinemia may be associated with a higher risk for type 2 diabetes and cardiovascular disease. Some studies suggest that adiponectin levels are modulated by lifestyle factors, but little is known about the associations between lifestyle factors and plasma adiponectin levels in Japanese people. We therefore investigated the associations between lifestyle factors and plasma adiponectin levels in general Japanese men.

Methods
The subjects were 202 Japanese male workers who participated in an annual health check. They provided details about anthropometrical data, blood collection, their use of prescribed medication, and the clinical history of their families. They also completed a self-administered questionnaire about their lifestyles.

Results
Subjects with plasma adiponectin levels below 4.0 μg/ml had significantly lower levels of HDL cholesterol and higher levels of BMI, SBP, DBP, total cholesterol, FBG, and platelets than did subjects with higher adiponectin levels. In multiple logistic regression after multiple adjustment, a plasma adiponectin level below 4.0 μg/ml was significantly associated with smoking (odds ratio [OR] = 2.08, 95% confidence interval [CI] = 1.01–4.30), a daily diet rich in deep-yellow vegetables (OR = 0.25, 95% CI= 0.07–0.91), frequent eating out (OR = 2.45, 95% CI = 1.19–5.08), and physical exercise two or more times a week (OR = 0.21, 95% CI = 0.06–0.74).

Conclusion
Our findings show that adiponectin levels in general Japanese men are independently related to smoking, dietary factors, and physical exercise. We think that lifestyle habits might independently modulate adiponectin levels and that adiponectin might be the useful biomarker helping people to avoid developing type 2 diabetes and cardiovascular disease by modifying their lifestyles.
Processing sites in the human immunodeficiency virus type 1 (HIV-1) Gag-Pro-Pol precursor are cleaved by the viral protease at different rates
Authors: Pettit Steve C , Lindquist Jeffrey N , Kaplan Andrew H , Swanstrom Ronald 
Published: November 2005

Abstract
We have examined the kinetics of processing of the HIV-1 Gag-Pro-Pol precursor in an in vitro assay with mature protease added in trans. The processing sites were cleaved at different rates to produce distinct intermediates. The initial cleavage occurred at the p2/NC site. Intermediate cleavages occurred at similar rates at the MA/CA and RT/IN sites, and to a lesser extent at sites upstream of RT. Late cleavages occurred at the sites flanking the protease (PR) domain, suggesting sequestering of these sites. We observed paired intermediates indicative of half- cleavage of RT/RH site, suggesting that the RT domain in Gag-Pro-Pol was in a dimeric form under these assay conditions. These results clarify our understanding of the processing kinetics of the Gag-Pro-Pol precursor and suggest regulated cleavage. Our results further suggest that early dimerization of the PR and RT domains may serve as a regulatory element to influence the kinetics of processing within the Pol domain.
Allelic imbalances of chromosomes 8p and 18q and their roles in distant relapse of early stage, node-negative breast cancer
Authors: Morikawa Aki , Williams Tanisha Y , Dirix Luc , Colpaert Cecile , Goodman Michael , Lyles Robert H , Zhong Diansheng , Zhou Wei 
Published: November 2005

Abstract
Introduction
Identification of breast cancer patients at risk for postoperative distant relapse is an important clinical issue. Existing pathological markers can predict disease recurrence only to a certain extent, and there is a need for more accurate predictors.

Methods
Using 'counting alleles', a novel experimental method, we determined allelic status of chromosomes 8p and 18q in a case-control study with 65 early stage, node negative, invasive ductal carcinomas (IDCs). The association between allelic imbalance (AI) of both chromosomal markers and distant relapses was examined.

Results
Eighty percent of tumors contained 8pAI and sixty-eight percent of tumors contained 18qAI. However, none of the tumor samples retained both chromosome 8p and 18q alleles. More importantly, tumors with 8pAI but not 18qAI were more likely to have distant relapse compared to tumors with 18qAI but not 8pAI.

Conclusion
Our finding suggests that differential allelic loss of chromosomes 8p and 18q may represent subtypes of early stage IDC with different tumor progression behaviors.
Disability and health-related quality of life in Guillain-Barré syndrome during the first two years after onset: a prospective study
Authors: Forsberg Anette , Press Rayomand , Einarsson Ulrika , de Pedro-Cuesta Jésus , Holmqvist Lotta Widén 
Published: October 2005

Objective: To describe changes in disability and health-related quality of life in patients with Guillain-Barré syndrome in Sweden during the first two years after onset. Subjects: Forty-four patients were recruited from eight different hospitals, and 42 of them (mean age 52 years) were followed for two years. Evaluations were performed, primarily as home visits, at two weeks, two months, six months, one year and two years after onset. Main measures: Disability was measured using the Katz Personal and Extended Activities of Daily Living Indexes, the Barthel Index, the Frenchay Activity Index and assessments of work capacity; health-related quality of life using the Sickness Impact Profile. Results: At two weeks, one year and two years after onset of Guillain-Barrésyndrome, 76%, 14% and 12% of patients were dependent in personal activities of daily life (ADL); and 98%, 28% and 26% were dependent in instrumental ADL. At two weeks, all of the patients that were working before onset were unable to work owing to Guillain-Barré syndrome; at two years, 17% were unable to work. At two weeks, scores on Sickness Impact Profile were elevated in all dimensions; at two years, they remained elevated in the physical dimension and in the categories home management, work and recreation and pastimes. Conclusions: The impact of Guillain-Barré syndrome on ADL, work, social activities and health-related quality is considerable two years after onset and presumably persists beyond this time point.
Effects of home exercises on motor performance in patients with Parkinson's disease
Authors: Caglar A T , Gurses H N , Mutluay F K , Kiziltan G 
Published: October 2005

Objective: To investigate the effect of home exercises on the motor performance of patients with Parkinson's disease. Design: A prospective blinded study with allocation of patients into their groups by alternate weeks. Setting: A University Hospital neurology and physiotherapy department. Subjects: Recruited from a movement disorders outpatient clinic of Cerrahpasa School of Medicine diagnosed with Parkinson's disease, classified as Hoehn and Yahr Grades I, II and III. Interventions: Patients who fulfilled the inclusion criteria were recruited to the study. Each patient was evaluated at the end of first and second month after the baseline evaluation. Patients were divided into two groups. Those in the first and third week were put in the exercise group and second and fourth week in the control group. Patients in the exercise group (n=15) were given a schedule of exercises to undertake at home; the others (n=15) did not receive this instruction. Measures: Ten- and 20-m walking test, first pace length, pace number in 10 m, walking around a chair, Nine Hole Peg Board (NHPB) test. Results: Following the home exercise programme, patients in the exercise group showed improvement in walking 10 and 20 m, time elapsed to complete walking around a chair and length of the first pace length, and in the motor performance of both hands (p < 0.001). Conclusions: A home-based rehabilitation programme for patients with Parkinson's disease helped to improve motor performance compared to patients who did not take advantage of a regular, professionally designed exercise programme.
Interfacing capillary electrophoresis with inductively coupled plasma mass spectrometry for redox speciation of plutonium
Authors: Ambard Chrystel , Delorme Arnaud , Baglan Nicolas , Aupiais Jean , Pointurier Fabien , Madic Charles 
Published: November 2005

Summary
A robust and efficient interface between a capillary electrophoresis (CE) and an ICP-MS for actinide speciation studies was developed. This interface was made of two stainless steel T-shape pieces connected to the ICP-MS through a PFA-50 nebulizer. Fast separations (typically in less that 15 min) were obtained. The performances of the technique in terms of chemical separations carried out by the capillary electrophoresis and in terms of detection limits were investigated. Concerning the detection limit of the CE-ICP-MS system for plutonium, it was determined as 5 × 10−10 mol L−1 or 9 × 10−18 mol under our injection conditions. The coupling enables to separate at least three (III, V and VI) of the four plutonium oxidation states which can exist in aqueous solutions and to monitor oxidation and reduction processes.
Influence of reaction channel on the isomeric cross-section ratio
Authors: Qaim Syed M. , Sudár S. , Fessler A. 
Published: November 2005

Summary
The influence of reaction channel on the isomeric cross-section ratio was investigated by analysing the experimental data on the reactions 52Cr(p, n)52m,gMn, 52Cr(3He, t)52m,gMn, 54Fe(d, α)52m,gMn, 54Fe(n, t)52m,gMn and 54Fe(3He, α p)52m,gMn over the incident particle energy range extending up to 35 MeV. The influence is most pronounced when the channels differ widely, for example (p, n) and (3He, t) processes, i.e. when the reaction mechanisms are different. The nuclear model calculational code EMPIRE-II described the isomeric cross-section ratio rather well in the case of a simple nucleon emission reaction, but not when complex reaction channels were involved.