bluuebunny/crossref_metadata_2025_split huggingface dataset:
Myeloid cell differentiation in response to calcitriol for expressionCD11bandCD14is regulated by myeloid zinc finger-1 protein downstream of phosphatidylinositol 3-kinase
Authors: Moeenrezakhanlou Alireza , Shephard Lindsay , Lam Lucia , Reiner Neil E 
Published: May 2008

AbstractImmature cells of the mononuclear phagocyte series differentiate in response to calcitriol. This is accompanied by increased expression of both CD11b and CD14 and has been shown to be phosphatidylinositol 3-kinase (PI3K) dependent. The events downstream of PI3K that regulate mononuclear phagocyte gene expression, however, remain to be fully understood. In the present study, we show that incubation of THP-1 cells with calcitriol brings about activation of the myeloid zinc finger-1 (MZF-1) transcription factor dependent upon PI3K. In addition, we show that the proximal promoter regions of both CD11b and CD14 contain functional MZF-1 binding sites that are calcitriol responsive. Site-directed mutagenesis of the putative MZF-1 elements abolished MZF-1 binding to the promoters of both CD11b and CD14. Not only did calcitriol treatment increase MZF-1 DNA binding activity to these sites, but it also up-regulated cellular levels of MZF-1. Silencing of MZF-1 resulted in a markedly blunted response to calcitriol for induction of both CD11b and CD14 mRNA transcript levels. Cell surface expression of CD11b and CD14 was also reduced, but to a lesser extent. Taken together, these results show that MZF-1 is involved downstream of PI3K in a calcitriol-induced signaling pathway leading to myeloid cell differentiation and activation of CD11b and CD14.
Socioeconomic Status and Social Support Following Illicit Drug Use: Causal Pathways or Common Liability?
Authors: Bergen Sarah E. , Gardner Charles O. , Aggen Steven H. , Kendler Kenneth S. 
Published: May 2008

AbstractThe negative social attributes associated with drug use and abuse/dependence may arise as a result of shared genetic or environmental factors rather than through causal pathways. To evaluate this possibility, structured interviews were conducted for 3969 male and female twins from the Mid-Atlantic Twin Registry and evaluations of their socioeconomic status (SES), social interactions, and use of drugs were obtained. Drug involvement was categorized as never used, tried, or met criteria for abuse or dependence. A co-twin control design was implemented using hierarchical linear modeling to assess whether twins who used drugs experienced lower SES and social support than non-using co-twins. Poorer social functioning in the drug-exposed twin is consistent with a causal relationship, while similar functioning in the drug exposed versus naive twins imply shared genetic or common environmental factors. Use of drugs was not significantly related to any SES measures. However, education and job status appear to share genetic influences with drug abuse/dependence. Lower income was not related to abuse/dependence of drugs. Negative interactions with friends and relatives share genetic factors with use of drugs, but the escalation from trying drugs to abusing them appears to generate discord between the abuser and friends and relatives in a causal fashion. These results indicate that presumptive causal influences of drug abuse/dependence on low SES may actually be mediated by shared genes. Drug use and social discord also appear to have shared genetic factors, but increased levels of drug involvement seem to causally influence social interactions.
Genetic Covariation Among Facets of Openness to Experience and General Cognitive Ability
Authors: Wainwright Mark A. , Wright Margaret J. , Luciano Michelle , Geffen Gina M. , Martin Nicholas G. 
Published: May 2008

AbstractGenetic and environmental sources of covariation among cognitive measures of verbal IQ, performance IQ (PIQ), academic achievement, 2-choice reaction time (CRT), inspection time (IT) and the 6 Openness facets of the NEO Personality Inventory-Revised (NEO PI-R) were examined. The number of twin and twin–sibling pairs ranged from 432 (182 MZ, 350 DZ/sibling) to 1023 (273 MZ, 750 DZ/sibling) for cognitive measures, and between 432 (90 MZ, 342 DZ/sibling) — 437 (91 MZ, 346 DZ/sibling) for Openness facets. Structural equation modeling best supported a model with a 3-factor additive genetic structure. A genetic general factor subsumed the 5 cognitive measures and 5 of the 6 Openness facets (Actions did not load significantly). A second additive genetic factor incorporated the 6 Openness facets, and a third additive genetic factor incorporated the 5 cognitive measures. Specific additive and dominance genetic effects were also evident, as were shared common and shared unique environmental influences, and specific unique environmental effects. The Openness facets of Ideas and Values evidenced the strongest phenotypic correlations with cognitive indices, particularly verbal measures. The genetic correlations among Openness facets and cognitive measures ranged from −.06 to .79. Results were interpreted as suggesting that Openness is related to general cognitive ability (g) through a genetic mechanism and thatgengenders a minor but discernable disposition towards Openness for the majority of facets.
Long-Term Stability and Heritability of Telephone Interview Measures of Alcohol Consumption and Dependence
Authors: Hansell Narelle K. , Agrawal Arpana , Whitfield John B. , Morley Katherine I. , Zhu Gu , Lind Penelope A. , Pergadia Michele L. , Madden Pamela A. F. , Todd Richard D. , Heath Andrew C. , Martin Nicholas G. 
Published: May 2008

AbstractAlcohol dependence symptoms and consumption measures were examined for stability and heritability. Data were collected from 12,045 individuals (5376 twin pairs, 1293 single twins) aged 19 to 90 years in telephone interviews conducted in three collection phases. Phases 1 and 2 were independent samples, but Phase 3 targeted families of smokers and drinkers from the Phase 1 and 2 samples. The stability of dependence symptoms and consumption was examined for 1158 individuals interviewed in both Phases 1 and 3 (mean interval = 11.0 years). For 1818 individuals interviewed in Phases 2 and 3 (mean interval = 5.5 years) the stability of consumption was examined. Heritability was examined for each collection phase and retest samples from the selected Phase 3 collection. The measures examined were a dependence score, based on DSM-IIIR and DSM-IV criteria for substance dependence, and a quantity × frequency measure. Measures were moderately stable, with test–retest correlations ranging from .58 to .61 for dependence and from .55 to .64 for consumption. However, the pattern of changes over time for dependence suggested that the measure may more strongly reflect recent than lifetime experience. Similar to previous findings, heritabilities ranged from .42 to .51 for dependence and from .31 to .51 for consumption. Consumption was significantly less heritable in the younger Phase 2 cohort (23–39 years) compared to the older Phase 1 cohort (28–90 years).
Genetics of Maximal Walking Speed and Skeletal Muscle Characteristics in Older Women
Authors: Tiainen Kristina M. , Perola Markus , Kovanen Vuokko M. , Sipilä Sarianna , Tuononen Katja A. , Rikalainen Kaisa , Kauppinen Markku A. , Widen Elisabeth I.M. , Kaprio Jaakko , Rantanen Taina , Kujala Urho M. 
Published: May 2008

AbstractThe aim of this study was to examine whether maximal walking speed, maximal isometric muscle strength, leg extensor power and lower leg muscle cross-sectional area (CSA) shared a genetic effect in common. In addition, we wanted to identify the chromosomal areas linked to maximal walking speed and these muscle characteristics and also investigate whether maximal walking speed and these three skeletal muscle characteristics are regulated by the same chromosomal areas. We studied 217 monozygotic (MZ) and dizygotic (DZ) female twin pairs aged 66 to 75 years in the Finnish Twin Study on Aging study. The DZ pairs (94) were genotyped for 397 microsatellite markers in 22 autosomes and X-chromosome. Genetic modeling showed that, muscle CSA, strength, power and walking speed shared a genetic effect in common which accounted for 7% of the variation in CSA, 51% in strength, 37% in power and 35% in walking speed. The results of an explorative multipoint linkage analysis suggested that the highest LOD score found for each phenotype was 2.41 for walking speed on chromosome 13q22.1, 2.14 for strength on chromosome 15q14, 2.84 for power on chromosome 8q24.23, and 2.93 for muscle CSA on chromosome 20q13.31. Also a suggestive LOD score, 2.68, for muscle CSA was found on chromosome 9q34.3. The chromosomal areas of a suggestive linkage for strength and power partly overlapped LOD scores higher than 1.0 being seen for these phenotypes on chromosome 15. The present study was the first genome-wide linkage analysis to be conducted for these multifactorial and clinically important phenotypes underlying functional independence in older women.
Design and Implementation of a Twin-Family Database for Behavior Genetics and Genomics Studies
Authors: Boomsma Dorret I. , Willemsen Gonneke , Vink Jacqueline M. , Bartels Meike , Groot Paul , Hottenga Jouke Jan , van Beijsterveldt C. E. M. Toos , Stroet Therese , van Dijk Rob , Wertheim Rien , Visser Marco , van der Kleij Frank 
Published: May 2008

AbstractIn this article we describe the design and implementation of a database for extended twin families. The database does not focus on probands or on index twins, as this approach becomes problematic when larger multigenerational families are included, when more than one set of multiples is present within a family, or when families turn out to be part of a larger pedigree. Instead, we present an alternative approach that uses a highly flexible notion of persons and relations. The relations among the subjects in the database have a one-to-many structure, are user-definable and extendible and support arbitrarily complicated pedigrees. Some additional characteristics of the database are highlighted, such as the storage of historical data, predefined expressions for advanced queries, output facilities for individuals and relations among individuals and an easy-to-use multi-step wizard for contacting participants. This solution presents a flexible approach to accommodate pedigrees of arbitrary size, multiple biological and nonbiological relationships among participants and dynamic changes in these relations that occur over time, which can be implemented for any type of multigenerational family study.
Mode of Conception of Twin Pregnancies: Willingness to Reply to Survey Items and Comparison of Survey Data to Hospital Records
Authors: van Beijsterveldt C. E. M. Toos , Hoekstra Chantal , Schats Roel , Montgomery Grant W. , Willemsen Gonneke , Boomsma Dorret I. 
Published: May 2008

AbstractBased on results from a survey study in a sample of Australian parents of twins, Raj and Morley (2007) reported that questions concerning the mode of conception of twins may be offensive to parents. We looked at the willingness to reply to questions about mode of conception of twin pregnancies in a large survey study that was completed by 20,150 mothers of twins from the Netherlands Twin Registry. Data collection took place in 2005/2006. The amount of missing data was examined and by using data from earlier survey studies, responders and nonresponders were compared with respect to their answers to questions on assisted reproduction techniques. In addition, we assessed the reliability of the question on mode of conception by comparing the survey data with hospital records in a subsample of 80 mothers of twins. We found no indication that mothers of twins were not prepared to reply to questions on mode of conception. Only a small number of mothers did not fill in the question on mode of conception (0.8%). Also, the use of artificial fertility techniques did not differ between mothers who returned and mothers who did not return the 2005/2006 survey. The comparison of the survey data with the hospital records showed that mothers can accurately report on the mode of conception of their twins.
Mechanical Evaluation of Mixed As-Cast and Friction Stir Processed Zones in Nickel Aluminum Bronze
Authors: Nolting Allison , Cheng Leon M. , Huang James 
Published: May 2008

Abstract
The performance of nickel aluminum bronze (NAB) propellers can be limited by the resistance of the alloy to fatigue. Friction stir processing (FSP) is a potential method for improving the fatigue life and fracture toughness of this material through grain structure refinement. As friction stir processing is a surface treatment, as-cast, thermo-mechanically affected zone (TMAZ), and FSP zone microstructures can all occur in components with thick cross sections and when FSP is performed on only selected areas of the component surface. The boundary between modified and unmodified microstructures produced by traditional processing techniques (i.e., heat affected zones produced by welding) are often the source of in-service failures as they can contain defects, residual stresses, deleterious microstructures or any combination thereof. In this paper, the mechanical behavior of FSP nickel aluminum bronze specimens containing as-cast, TMAZ, and FSP microstructures are evaluated using monotonic tensile tests and rotating bending fatigue tests. Analysis of the fatigue specimen fracture surfaces indicate that fatigue cracks initiated and propagated through the as-cast microstructure before penetrating the TMAZ and the FSP microstructures. The tensile specimens failed in the as-cast structure away from the FSP zone and the TMAZ. These results indicate that the as-cast material is weaker than both the FSP and the TMAZ, implying that localized friction stir processing is not detrimental to the mechanical behavior of a NAB component, even in the boundary region.
Increased aortic root diameters in patients with acromegaly
Authors: van der Klaauw Agatha A , Bax Jeroen J , Smit Johannes W A , Holman Eduard R , Delgado Victoria , Bleeker Gabe B , Biermasz Nienke R , Roelfsema Ferdinand , Romijn Johannes A , Pereira Alberto M 
Published: May 2008

ObjectiveThe clinical manifestations of acromegalic cardiomyopathy include arrhythmias, valvular regurgitation, concentric left ventricular (LV) hypertrophy, and LV systolic and diastolic dysfunction. At present, it is unknown whether acromegaly also affects the aortic root.DesignAortic root diameters were prospectively assessed in 37 acromegalic patients (18 patients with active disease and 19 with controlled disease) by conventional two-dimensional and Doppler echocardiography before, and after, an observation period of 1.9 years (range 1.5–3.0 years). Baseline parameters were compared with healthy controls.ResultsThe diameters of the aortic root at the sino-tubular junction and the ascending aorta were increased in patients with acromegaly: 30±4 vs 26±3 mm (P=0.0001) and 33±5 vs 30±4 mm (P=0.006) respectively. The diameter of the aortic root at the aortic annulus and aortic sinus were not different from controls. During follow-up, the aortic root diameters increased at the levels of the annulus and the sinotubular junction (P=0.025 and P=0.024 respectively), whereas there was no change in the diameters at the levels of the sinus and the ascending aorta during follow-up. Baseline aortic root diameters were not influenced by disease duration, current disease activity, or blood pressure. When patients with active and inactive disease were analyzed separately, only the diameter of the sinotubular junction increased in patients with inactive acromegaly during follow-up (P=0.031).ConclusionAortic root diameters are increased in patients with acromegaly compared with healthy controls.
Fortification of some Egyptian foods with soybean
Authors: Abdel‐Rahman Abdel‐Hamid Y. , Youssef Soad A. M. 
Published: May 2008

AbstractFlours from full fat and defatted soybeans were made in the laboratory and used as supplements to Egyptian bread and two popular legume foods (lentil soup and falafil). The effect of fortification level on water absorption, dough rheology, loaf quality, and major chemical constituents of fino (pulp) and Arabic (flat) breads were investigated. Water absorption was slightly affected, dough mixing time, stability, and valorimetric values increased, but the mixing tolerance index decreased by adding defatted soy flour to wheat flour. Loaves were slightly smaller in volume than the control at high levels of defatted soy flour. Morover, bread score and panel evaluation showed deterioration of fino bread characteristics above 6% and Arabic bread above 8% defatted soy flour, but above 3% full fat soy. Organoleptic properties of the enriched lentil soup and falafil were similar to those of control at a level of 25% and 50% full fat soy and of 40% and 60% defatted soy flour, respectively. The most favorable change of the chemical composition of lentil soup and falafil is the increased protein content. Also, increasing the level of defatted soy flour increased ash content and decreased the level of fat absorption by fried falafil. On the other hand, increasing the level of full fat soy may replace the addition of shortening to lentil soup to make it more palatable.
Neo acids: Synthetic highly branched organic acids
Authors: Fefer M. 
Published: May 2008

AbstractNeo acids are highly branched synthetic trialkyl acetic acids manufactured by reacting an olefin with high purity carbon monoxide under high pressure in the presence of an acidic‐type catalyst. The starting olefins for neopentanoic (C5, single isomer) and neodecanoic (C10, mixed isomers) acids are isobutylene and nonene, respectively. Commercial quantities of both products have been available since 1964. Neopentanoic acid is used in the preparation of t‐butyl peroxy neopentanote (pivilate), a peroxyester initiator used in polyethylene manufacture. The C5 neo acid also finds use in a variety of other industrial end uses, e.g., pharmaceutical, agricultural chemicals, and reaction of form hindered, very stable esters. Metal salts of neodecanoic acid are used in paint driers, PVC stabilizers, and peroxyester initiators. Other reactions such as esterification, amide formation, and reaction with ethylene oxide will be discussed.
Chemical reactions involved in the deep‐fat frying of foods: VIII. Characterization of nonvolatile decomposition products of triolein
Authors: Paulose M. M. , Chang Stephen S. 
Published: May 2008

AbstractTriolein was heated under simulated deep‐fat frying conditions at 185 C for 74 hr. The thermally oxidized triolein was converted into methyl esters and then fractionated by urea exclusion. The urea adduct‐forming ester (89.2%) was found to be methyl oleate unchanged by the frying treatment. The nonurea adduct‐forming esters (10.8%) were further fractionated by silicic acid column chromatography into nine fractions with molecular weights ranging from 304 to 742. Physical and chemical analyses of the fractions indicated that some of them contained oxygen atoms which could not be accounted for by ordinary functional group analyses. The polymers isolated were formed by both carbon‐to‐carbon and carbon‐to‐oxygen linkages. The nonpolar dimers were further purified by thin layer and gas chromatography. Structure elucidation revealed that they consisted of a noncyclic dimer and a noncyclic dimer containing a carbonyl group, each of which amounted to 1.36% of the triolein originally used. The polar polymers were studied by depolymerization and the analysis of the depolymerized products. It was estimated that the triolein used for simulated deep fat frying contained 1.1% trimers formed through carbon‐to‐carbon linkages, 1.9% dimers and trimers joined through carbon‐to‐carbon linkages, and 3.1% dimers and trimers joined through carbon‐to‐oxygen or carbon‐to‐carbon linkages in the same molecule and also dimers and trimers in which all the monomeric units were joined through carbon‐to‐oxygen linkages. The precise form of the oxygen linkages are not known. However, the fact that it is not cleavaged by HC1 and HI suggests ether linkages.
Laboratory‐scale continuous hydrogenation
Authors: Snyder Janet M. , Dutton H. J. , Scholfield C. R. 
Published: May 2008

AbstractData required for modeling and simulation of continuous hydrogenation kinetics have been obtained in an isothernal, cocurrent flow‐type reactor. A preheated suspension of catalyst in oil, mixed with hydrogen, is passed cocurrently through 10 m length of 0.12 cm ID Teflon tubing at flow rates varying from 1.5 to 4.5 ml/min, gas flow rates from 100 to 700 ml/min, and temperatures from 150 to 190 C. The hydrogenations are run using nickel catalyst at outlet pressures of one atmosphere. Samples are removed at equal intervals along the length of the reactor and analyzed by gas chromatography. The kinetics of the continuous reactor are satisfactorily modeled by the simple scheme Ln→Lo→01→S using first order kinetics. Reaction rates, calculated by a digital computer, are shown to be related to temperature by the Arrhenius equation.trans Content and degree of hydrogenation are increased with temperature are decreased as oil flow increases. Hydrogen flow rate has little or no effect over the range studied.
Selective hydrogenation of soybean oil: IX. Effect of pressure in copper catalysis
Authors: Mounts T. L. , Koritala S. , Friedrich J. P. , Dutton H. J. 
Published: May 2008

AbstractSelective hydrogenation of soybean oil with copper catalyst at 50 psig or less is characterized as a relatively slow reaction requiring higher catalyst concentrations than the less selective but rapid nickel‐catalyzed reactions used in most commercial practice. Hydrogenations of soybean oil have been performed which included a high‐pressure scan (500, 1000, and 3000 psig), at selected temperatures (110, 130, 150, and 170 C), and at specific catalyst concentrations (0.05, 0.1, 0.2, and 0.4% copper). Selectivities, relative reaction rates, and geometric and positional isomerization have been determined as an evaluation of the effects of high pressure on the kinetics of the reaction. The experimental results indicate that an appropriate selection of pressure, temperature, and catalyst concentration can permit: (a) a significant increase in the rate of reaction while retaining the high linolenic acid selectivity of copper catalysts, (b) use of lower concentrations of copper catalyst while maintaining the higher reaction rate, and (c) elimination of conjugated diene as a measureable product in the hydrogenated oil.
Cephalaria syriaca seed oil
Authors: Yazicioğlu T. , Karaali A. , Gökçen J. 
Published: May 2008

AbstractCephalaria syriaca shrad., in Turkish pelemir, grows predominantly in the southeastern district of Turkey as a weed in cereal fields. Pelemir seeds are sometimes used for extraction of their oil, as an improver of baking value of wheat, and as an antistaling agent for bread. The seeds contain 7.8% moisture; their chemical composition on a dry basis is: crude fat, 25.3%, crude protein, 15.9%; N‐free extract, 40.4%; crude fiber, 11.9%; crude ash, 6.5%. Characteristics of the seed oil are: specific gravity at 25 C, 0.9229; refractive index at 25 C, 1.4706; saponification value, 192; iodine value, 88.4; thiocyanogen value, 58.8; Reichert‐Meissl value, 0.36; Polenske value, 0.25; unsaponifiable matter, 1.24%; hydroxyl value, 20.9. The fatty acid components are: lauric acid, 1.5%; myristic acid, 19.5%; palmitic acid, 9.4%; stearic acid, 2%; oleic acid, 23.0%; linoleic acid, 36.9%. The chemical composition of extracted cakes on a dry basis is: crude protein, 20.4%; crude fat, 0.8%; N‐free extract, 50.5%; crude ash, 6.4%; crude fiber; 14.4%%; saponin, 7.5%. The oil contains 7.8% epoxy acid, calculated as epoxy oleic acid, which makes its use as an edible oil rather difficult but renders it usable in industries using epoxidized oils. Due to its high content of myristic acid, the oil is very suitable for soapmaking as well.