bluuebunny/crossref_metadata_2025_split huggingface dataset:
The changes and its significance of peripheral blood NK cells in patients with tuberculous meningitis
Authors: Mi Jie , Liu Yinping , Xue Yong , Sun Wenna , Liang Yan , Liang Jianqin , An Huiru , Wu Xueqiong 
Published: February 2024

ObjectiveTuberculous meningitis (TBM) is the most severe form of tuberculosis (TB). The purpose of this study was to explore the relationship between the number of natural killer (NK) cells and adaptive immune status, and disease severity in TBM patients.MethodsWe conducted a retrospective study on 244 TB patients and 146 healthy control subjects in the 8th Medical Center of the PLA General Hospital from March 2018 and August 2023.ResultsThe absolute count of NK cells in the peripheral blood of TBM patients was significantly lower than that in normal controls (NC), latent tuberculosis infection (LTBI), and non-severe TB (NSTB) patients (p &lt; 0.05). The proportion of TBM patients (48.7%) with a lower absolute count of NK cells than the normal reference value was significantly higher than that in NC (5.2%) and LTBI groups (4.0%) (p &lt; 0.05), and slightly higher than that in NSTB group (36.0%) (p &gt; 0.05). The absolute counts of lymphocyte subsets in TBM combined with other active TB group, etiology (+) group, IGRA (−) group, and antibody (+) group were lower than that in simple TBM group, etiology (−) group, IGRA (+) group, and antibody (−) group, respectively. The CD3+ T, NK, and B cells in BMRC-stage III TBM patients were significantly lower than those in stage I and stage II patients (p &lt; 0.05). The counts of CD3+ T, CD4+ T, and B cells in the etiology (+) group were significantly lower than those in the etiology (−) group (p &lt; 0.05).ConclusionThe absolute counts of lymphocyte subsets in the peripheral blood of TBM patients were significantly decreased, especially in NK cells. The reduction of these immune cells was closely related to the disease severity and had a certain correlation with cellular and humoral immune responses. This study helps to better understand the immune mechanism of TBM and provides reliable indicators for evaluating the immune status of TBM patients in clinical practice.
Case report: Acute HHV6B encephalitis/myelitis post CAR-T cell therapy in patients with relapsed/refractory aggressive B-cell lymphoma
Authors: Li Ningwen , Zhang Ruoxuan , Wang Jue , Zhu Xiaojian , Meng Fankai , Cao Yang , Wang Gaoxiang , Yang Yang 
Published: February 2024

BackgroundThe development of chimeric antigen receptor (CAR)-T cell therapy has revolutionized treatment outcomes in patients with lymphoid malignancies. However, several studies have reported a relatively high rate of infection in adult patients following CD19-targeting CAR T-cell therapy, particularly in the first 28 days. Notably, acute human herpesvirus 6 B (HHV6B) reactivation occurs in up to two-thirds of allogeneic hematopoietic stem cell transplantation patients.Case presentationsHerein, we describe a report of HHV6B encephalitis/myelitis in three patients with relapsed/refractory diffuse large B-cell lymphoma post CAR T-cell therapy. All three patients received multiple lines of prior treatment (range: 2–9 lines). All patients presented with fever that persisted for at least 2 weeks after CAR-T cell infusion (CTI). Both the onset time and duration were similar to those of the cytokine release syndrome (CRS); nevertheless, the CRS grades of the patients were low (grade 1 or 2). Delirium and memory loss after CTI were the earliest notable mental presentations. Neurological manifestations progressed rapidly, with patients experiencing varying degrees of impaired consciousness, seizures, and coma. Back pain, lumbago, lower limb weakness and uroschesis were also observed in Patient 3, indicating myelitis. High HHV6B loads were detected in all Cerebral spinal fluid (CSF) samples using metagenomic next-generation sequencing (mNGS). Only one patient required high-activity antivirals and IgG intravenous pulse treatment finally recovered, whereas the other two patients died from HHV6B encephalitis.ConclusionConsidering its fatal potential, HHV6B encephalitis/myelitis should be urgently diagnosed post CAR-T cell-based therapy. Furthermore, hematologists should differentially diagnose these conditions from CRS or other immunotherapy-related neurotoxicities as early as possible. The results of this study demonstrate the potential of mNGS in the early diagnosis of HHV6B infection, particularly when the organism is difficult to culture.
Estimation of dietary intake of sodium, potassium, phosphorus and protein in healthy Indian population and patients with chronic kidney disease
Authors: Kaur Prabhjot , Yadav Ashok Kumar , Pal Arnab , Jassal Ravjit Singh , Shafiq Nusrat , Sahni Nancy , Kumar Vivek , Jha Vivekanand 
Published: February 2024

IntroductionPoor nutritious diet is a major risk element for non-communicable diseases (NCD), which are of considerable public health concern. Given the diverse dietary patterns in India, precise determination of nutrient consumption is crucial for disease management. The present study assessed the dietary intake of sodium, potassium, protein, and phosphorus among North Indians.MethodsThis cross-sectional study included healthy adults and adults with stage 2 to 4 chronic kidney disease (CKD). We analysed sodium, protein, potassium and phosphorus intakes using one-time 24-h urinary excretion. Dietary intake was also analysed in subgroups based on sex, body mass index, blood pressure and abdominal obesity. We evaluated the performance of various equations available to estimate sodium intake using a spot urine sample with respect to the sodium excretion measured in a 24-h urine sample. Descriptive statistics was used along with t-test for statistical significance.ResultsA total of 404 subjects (182 adult healthy subjects and 222 adults with CKD) with a mean age of 47.01 ± 11.46 years were studied. Mean dietary intakes of sodium, salt, potassium, protein and phosphorus were 2.94 ± 1.68 g/day, 7.42 ± 4.24 g/day, 1.43 ± 0.59 g/day, 47.67 ± 14.73 g/day and 0.86 ± 0.39 g/day, respectively. There were no differences in nutrient consumption between adults who were healthy and those with CKD. Consumption of sodium, salt, protein, potassium, and phosphorus among healthy population vs. those with CKD were 2.81 ± 1.60 vs. 3.05 ± 1.73 g/day (p = 0.152), 7.08 ± 4.04 vs. 7.70 ± 4.37 g/day (p = 0.143), 47.16 ± 14.59 vs. 48.08 ± 14.86 g/day (p = 0.532), 1.38 ± 0.59 vs. 1.48 ± 0.58 g/day (p = 0.087) and 0.86 ± 0.41 vs. 0.87 ± 0.37 g/day (p = 0.738), respectively. Men had higher consumption of these nutrients than women. Compared to non-hypertensives, hypertensive subjects had higher consumption of salt (8.23 ± 4.89 vs. 6.84 ± 3.59 g/day, p = 0.002) and potassium (1.51 ± 0.63 vs. 1.38 ± 0.55 g/day, p = 0.024), however, no difference were found in protein and phosphorus intakes. In terms of performance of equations used to estimate 24-h sodium intake from spot urinary sodium concentration against the measured 24-h urinary sodium excretion, INTERSALT 2 equation exhibited the least bias [1.08 (95% CI, −5.50 to 7.66)].ConclusionThe study shows higher-than-recommended salt and lower-than-recommended potassium intake in the north Indian population compared to those recommended by guidelines. The dietary protein intake is below the recommended dietary allowance. These findings help the development of targeted policies for dietary modification to reduce the risk of the development and progression of CKD.
Population-based screening for colorectal cancer in Wuhan, China
Authors: Liu Song , Wang Yifan , Wang Yuying , Duan Chaofan , Liu Fan , Zhang Heng , Tian Xia , Ding Xiangwu , Zhang Manling , Cao Dan , Liu Yi , Jiang Ruijingfang , Zhuo Duan , Peng Jiaxi , Zhu Shida , Zhao Lijian , Wang Jian , Wei Li , Shi Zhaohong 
Published: February 2024

Fecal DNA test has emerged as a non-invasive alternative for colorectal cancer (CRC) screening in average-risk population. However, there is currently insufficient evidence in China to demonstrate the effectiveness of population-based CRC screening using fecal DNA based test. Here, a large-scale real-world study for CRC screening was implemented in Wuhan, Hubei province, China. A total of 98,683 subjects aged between 45 and 60 years were screened by a fecal DNA test (ColoTect®) which detected methylation status of SDC2, ADHFE1, and PPP2R5C. Participants who tested positive were advised to receive diagnostic colonoscopy. 4449 (4.5%) subjects tested positive for fecal DNA test, and 3200 (71.9%) underwent colonoscopy. Among these, 2347 (73.3%) had abnormal colonoscopy findings, of which 1330 (56.7%) subjects received pathological diagnosis. Detection rates for CRC and advanced precancerous lesions were 1.3% and 2.3%, respectively. Detection rates for nonadvanced adenomas and polyps were 14.0% and 21.6%, respectively. 28.0% of all colonoscopies showed colorectal neoplasm but lack pathological diagnosis. 6.1% showed other abnormalities such as enteritis. In conclusion, preliminary real-world evidence suggested that fecal DNA tests had promising diagnostic yield in population-based CRC screening.Clinical trial registrationhttps://www.chictr.org.cn/showproj.html?proj=192838, identifier ChiCTR2300070520.
The potential causal relationship between various lifestyles and depression: a univariable and multivariable Mendelian randomization study
Authors: Guo Shaobo , Zhu Wenhui , Yu Likai , Jie Lishi , Tian Di , Zhao Tianci , Zhao Biqing , Zhang Biao 
Published: February 2024

BackgroundPrevious studies have shown that lifestyle was associated with depression. Thus, the aim of this study was to examine the causality between multiple lifestyles and depression by Mendelian randomization (MR) analysis.MethodsThe single-nucleotide polymorphisms (SNPs) of depression, alcoholic drinks per week, sleeplessness or insomnia, body mass index (BMI), mood swings, weekly usage of mobile phone in the last 3 months, beef intake, cooked vegetable intake, and “smoking status: never” were acquired from the Integrative Epidemiology Unit Open genome-wide association study database. Causal effects of eight exposure factors and depression were investigated using MR-Egger, weighted median, inverse variance weighted (IVW), simple mode, and weighted mode, and results were primarily referred to IVW. Subsequently, univariable MR (UVMR) analysis was performed on eight exposure factors and depression, separately. In addition, sensitivity analysis, including heterogeneity test, horizontal pleiotropy, and leave-one-out (LOO) methods, was conducted to evaluate the stability of MR results. Furthermore, multivariable MR (MVMR) analysis was carried out.ResultsUVMR analysis revealed that all eight exposure factors were causally associated with depression; alcoholic drinks per week, sleeplessness or insomnia, BMI, mood swings, weekly usage of mobile phone in the last 3 months, and cooked vegetable intake were risk factors, and beef intake and “smoking status: never” were protection factors. Heterogeneity tests revealed no heterogeneity for alcoholic drinks per week, sleeplessness or insomnia, mood swings, weekly usage of mobile phone in the last 3 months, and cooked vegetable intake. Meanwhile, there was no horizontal pleiotropy in UVMR, and LOO analysis verified that univariable analysis results were reliable. Moreover, MVMR analysis indicated that mood swings and weekly usage of mobile phone in the last 3 months were risk factors, and beef intake was a protection factor for depression when multiple factors occurred at the same time.ConclusionAlcoholic drinks per week, sleeplessness or insomnia, BMI, mood swings, weekly usage of mobile phone in the last 3 months, and cooked vegetable intake were risk factors, and beef intake and “smoking status: never” were protection factors. In addition, mood swings, weekly usage of mobile phone in the last 3 months, and beef intake had a direct effect on depression when multiple factors occurred simultaneously.
Effects of empathy on the bidirectional relationships between problematic smartphone use and aggression among secondary school students: a moderated network approach
Authors: Wu Wenxia , Zou Xinyuan , Tang Qihui , Tao Yanqiang , Wang Shujian , Ma Zijuan , Li Min , Liu Gang 
Published: February 2024

BackgroundExisting literature on the relationship between problematic smartphone use (PSU) and aggression has primarily focused on examining their unidirectional association, with limited attention paid to the bidirectional nature of this relationship, particularly when considering the role of empathy. This study employs a novel moderated network approach to examine the bidirectional relationship between problematic smartphone use and aggression, while also investigating the moderating mechanism of empathy.MethodsA total of 2,469 students (49.1% female, Meanage = 13.83, SDage = 1.48) from 35 junior and senior high schools in Harbin, China, participated in this study. Empathy level, aggressiveness, and PSU symptoms were assessed using the Basic Empathy Scale, the Buss-Warren Aggression Questionnaire, and the Mobile Phone Addiction Index.ResultsAnalysis revealed that the relationship between PSU and aggression was complex and bidirectional. The strongest association was observed between “hostility” and “withdrawal/escape”. In addition, “anger” had the highest Expected Influence (EI) in both affective and cognitive moderate network models. An important discovery was also made regarding the conditional effect of “productive loss” and “physical aggression” across different levels of affective empathy. Specifically, at lower levels of affective empathy, a positive bidirectional relationship was found between “productive loss” and “physical aggression”. However, this relationship turned negative and bidirectional at higher levels of affective empathy.ConclusionThe findings contribute to a more comprehensive understanding of the complex dynamics between PSU and aggression and highlight the need for targeted interventions that promote affective empathy to mitigate the negative consequences of excessive smartphone use.
STRATEGI PEMBERDAYAAN MASYARAKAT PELAKU UMKM PADA MASA PANDEMI COVID-19 DI DESA MEKARJAYA KABUPATEN KARAWANG
Authors: Nana Rahdiana  , Dena Meliana  , Sukarman  , Tri Oktaviani  , Siti Nur Suhaeni  , Lusi Hildawati  , Shintia  , Rizka Dwi Alfinda  
Published: February 2024

Pandemi Covid-19 sampai saat ini belum berakhir di Indonesia, dampaknya sangat dirasakan oleh seluruh lapisan masyarakat, para pelaku ekonomi, dan perekonomian nasional. Salah satu pelaku ekonomi yang akan dikaji adalah Usaha Mikro Kecil Menengah (UMKM), kegiatan usahanya berpotensi mengalami kerugian dan gulung tikar. Penurunan daya beli masyarakat akibat pandemi berkepanjangan, menambah buruk kondisi UMKM. Oleh karena perlu perhatian dan bantuan dari banyak pihak terutama pemerintah, swasta, dan akademisi kepada UMKM agar mampu melewati masa-masa sulitnya. Dibutuhkan strategi-strategi baru untuk menggairahkan kembali kegiatan[1]kegiatan UMKM. Melalui program pengabdian kepada masyarakat tim PKM berusaha untuk menerapkan strategi-strategi marketing, untuk pemberdayaan masyarakat pelaku UMKM, untuk membangun kekuatan ekonomi nasional dimasa depan. Program digitalisasi atau pemanfaatan pasar digital menjadi pilihan tepat sebagai strategi pemberdayaan masyarakat pelaku UMKM pada masa pandemi Covid-19 sehingga dapat menjangkau calon pelanggan yang lebih luar. Dalam mengenalkan dan memasarkan produk UMKM ibu Erin telah memanfaatkan media sosial facebook dan instagram, serta pasar digital seperti shopee.
Improving Civics Learning Outcomes Through the Scramble Learning Model for Class V Students Elementary School
Authors: Murjinah Murjinah , Choerifki Siti , Chung Ming-Lun 
Published: February 2024

Purpose of the study: This research aims to improve Civics (Citizenship Education) learning outcomes using the scramble learning model for fifth grade students at Prawirotaman Yogyakarta State Elementary School
Methodology: This research is ex-post researchThis type of research is classroom action research. The research subjects were 17 students in class V of Prawirotaman State Elementary School, Yogyakarta. Data collection methods in research include tests, observation and documentation. The research instruments are tests and learning implementation sheets. The data analysis technique used is quantitative and qualitative descriptive. The indicator of the success of the action is marked by ≥75% of the total number of students who took part in the learning process having obtained a score of ≥75.
Main Findings: The main finding of this research is improvementCivics learning outcomes for fifth grade students at Prawirotaman State Elementary School, Yogyakarta after using the scramble learning model in cycle I and cycle II.Based on test results in implementing learning with modelsscramble learning , students who achieved a score of ≥75 were 70.59% in cycle I and increased to 88.24% in cycle II. The increase in learning outcomes occurred after improvements in actions in cycle II, namely the teacher divided the groups more clearly, the number of group members was reduced, andgiving rewards to calm students. The action is dismissed on the cyclebecause it has achieved the success criteria.
Novelty/Originality of this study: The Scramble learning model is designed to improve understanding of concepts. Research can evaluate the extent to which Civics learning outcomes have improved, especially in understanding the concept of citizenship.
Pengambilan Keputusan Kiai di Pondok Pesantren : Analisis Bibliometrik dengan VOSViewer
Authors: Hafidh Zaini , Nurdin  
Published: February 2024

Penelitian ini bertujuan untuk menganalisis sebaran artikel penelitian dengan tema pengambilan keputusan kiai di pondok pesantren. VosViewer digunakan sebagai alat Analisis dalam penelitan serta menggunakan pendekatan bibliometrik, referensi artikel didapat google scholar dengan dukungan publish or perish dan ditemukan 987 artikel yang dianggap relevan topik terkait. Periode penelitian yang digunakan sebagai dokumen yang terindeks google scholar adalah dari 2014-2023. Hasil penelitian difokuskan untuk mencari dan menganalisis topik yang memiliki keterkaitan dengan penambilan keputusan kiai di pondok pesantren dan analisis data lainnya. Kata Kunci tentang pendidikan akrakter di pondok pesantren dikaitkan dengan 4 cluster dengan total 189 link dan 1754 total link strength. Hasil analisis perkembangan publikasi dalam periode 2019-2022 penelitian tentang tema pengambilan keputusan kiai di pondok pesantren cukup banyak di teliti oleh para peneliti tentang kiai atau pondok pesantren. Jumlah publikasi terbanyak tahun 2023 sebanyak 272 artikel dan paling sedikit tahun 2014 sebanyak 14 artikel. Topik ini menjadi hal yang menarik untuk terus diteliti oleh peneliti selanjutnya, hal ini berkenaan dengan adanya grafik peningkatan tema ini setiap tahun yang menandakan bahwa topik riset berkenaan dengan kiai dan pondok pesantren semakin di minati oleh para peneliti, hal ini akan memberikan dampak yang sangat besar bagi pngembangan pondok pesantren kedepannya.
This research aims to analyze the distribution of research articles on the theme of kiai decision-making in Islamic boarding schools. VosViewer was used as an analysis tool in research and used a bibliometric approach. Article references were obtained by Google Scholar with publish or perish support, and 987 articles were found that were considered relevant to the related topic. The research period used for documents indexed by Google Scholar is from 2014 to 2023. The research results focused on finding and analyzing topics that are related to kiai decision-making in Islamic boarding schools and other data analyses. Keywords about character education in Islamic boarding schools are associated with 4 clusters with a total of 189 links and 1754 total link strengths. The results of the analysis of the development of publications in the 2019–2022 period show that research on the theme of kiai decision-making in Islamic boarding schools has been studied quite a lot by researchers about kiai or Islamic boarding schools. The highest number of publications in 2023 was 272 articles, and the least in 2014 was 14 articles. This topic is an interesting thing to continue to be researched by future researchers. This is due to the graph of the increase in this theme every year, which indicates that research topics relating to kiai and Islamic boarding schools are increasingly of interest to researchers. This will have a very big impact on the future development of Islamic boarding schools.
Peran Agama Dalam Perubahan Sosial Masyarakat
Authors: Ali Fathudin , Zuhdi Muhammad , Mudzakir  
Published: February 2024

Dalam peranan agama sangat penting dalam suatu kehidupan manusia di muka bumi ini atau didunia, untuk mencapai kebahagian didunia dan menuju kebahagian diakhirat kelak. agama dalam kehidupan manusia berfungsi penyelaras kehidupan dan sebagai pedoman hidup, didalam suatu perubahan sosial yang terjadi dan dialami oleh masyarakat, agama memiliki fungsi untuk membentengi dari suatu yang jahat dan mengarahkan ke suatu yang lebih baik. agama memiliki ajaran yang berpengaruh besar dalam menyatukan pandangan dalam kehidupan masyarakat. agama hadir didalam kehidupan manusia secara fungsional sebagai perekat sosial, menumbuhkan rasa solidaritas, mempererat siaturahmi atau kekeluargaan, menciptakan perdamaian, control sosial, mengubah kehidupan manusia agar lebih baik sehingga mendapatkan keselamatan didunia maupun diakhirat dan seperangkat peranan yang kesemuanya hal ini dalam menjaga kestabilan sosial didalam masyarakat.
The role of religion is very important in human life on this earth or in the world, to achieve happiness in the world and towards happiness in the afterlife. Religion in human life functions to harmonize life and as a guide to life. In social changes that occur and are experienced by society, religion has the function of protecting against something evil and directing it to something better. Religion has teachings that have a big influence in unifying views in people's lives. Religion is present in human life functionally as a social glue, fostering a sense of solidarity, strengthening friendship or kinship, creating peace, social control, changing human life for the better so that they obtain safety in this world and the hereafter and a set of roles, all of which are in maintaining social stability in the world. public.
L’association sos Villages d’enfants, l’audace à la croisée des besoins des enfants et des territoires
Authors: Foignet-Pohren Fabienne 
Published: February 2024

Depuis près de soixante-dix ans, sos Villages d’enfants accueille des fratries séparées de leurs parents sur décision de justice pour leur offrir un point d’ancrage et une ressource affective. L’association s’est développée dans les années 1950 sur une logique de suppléance parentale en lien avec les orphelins de guerre, comme le firent beaucoup d’œuvres caritatives de l’époque. Elle évolue au cours des décennies suivantes vers une approche de la suppléance parentale qui prend en compte la place des familles même dans un contexte d’investissement. La valeur centrale et historique de l’association réside dans sa volonté de n’accueillir de façon non négociable que des frères et sœurs. Nous souhaitons ici mettre en avant une initiative récente de création d’un village dit « de tout-petits », à la croisée des attentes du département du Nord et des compétences de l’association sos Villages d’enfants. Si la focalisation sur une tranche d’âge spécifique ainsi que la modification structurelle de l’organisation en ce sens démontrent les innovations possibles de ses équipes interdisciplinaires, la prédominance de l’esprit de famille et du lien d’attachement comme gage principal de la croissance psychique restent les principes conducteurs.
Auschwitz à l’épreuve de la photographie
Authors: Halpérin Jean-Louis 
Published: February 2024

(À propos de : Tal Bruttmann, Stefan Hördler et Christoph Kreutzmüller, Un album d’Auschwitz. Comment les nazis ont photographié leurs crimes , trad. de l’allemand par Olivier Mannoni, préface de Serge Klarsfeld, Paris, Seuil, 2023, 303 p.)