bluuebunny/crossref_metadata_2025_split huggingface dataset:
Papillary thyroid cancer in identical twins
Authors: Chandler James J. , Schwartz Michael J. , Stahl Theodore J. , Lee Leung 
Published: February 2007

AbstractThe cases of a set of 19‐year old monozygotic twins are presented‐the first report of thyroid cancer of follicular origin occurring in identical twins. This report includes a brief review of reports of cancer of various sites in twins. Several studies and reports emphasize genetic factors influencing the concurrence of cancer. Other reports downgrade the likelihood of genetic influence in cancer.
Diaphragmatic neurilemoma
Authors: McHenry Christopher R. , Pickleman Jack , Winters Gayle , Flisak Michael E. 
Published: February 2007

AbstractThe fourth case of diaphragmatic neurilemoma reported in the English literature is presented from our institution. Diaphragmatic tumors are usually benign and most are symptomatic. Utilizing CT scanning, these tumors can today be accurately localized. Excision via thoracotomy or celiotomy is easily accomplished and is the only reliable way to establish the identity of these lesions.
Laparotomic eventration or colonic prolapse after chemotherapy‐induced emesis
Authors: Martin‐Jimenez Miguel , Diaz‐Rubio Eduardo , Sangro Bruno , Marote Rosa 
Published: February 2007

AbstractFour cases of patients suffering from abdominal scar injuries (laparotomic eventration and colonic prolapse through the site of previous colostomy) associated with antineoplastic chemotherapy‐induced emesis are presented. The hypothesis of emetic strain as the main cause of eventration of prolapse is discussed. The authors suggest the need of a routine prophylactic antiemetic treatment in patients submitted to abdominal surgery and subsequent antineoplastic chemotherapy in order to avoid these accidents.
Effect of cyclosporine and irradiation on experimental pancreatic allografts in the primate
Authors: Du Toit Don F. , Heydenrych Jacobus J. , Smit Ben , Zuurmond Theuns , Louw Gabriel , Els Daniel , Baker Lida , Wlideman André , Wolfe‐Coote Sonia , Du Toti Looraine , Davids Henry , Groenewald Wilhelm , Van Der Merwe Emuel , Pistorius Stephen 
Published: February 2007

AbstractThe present study assessed the effectiveness of cyclosporine (CSA) and subtotal marrow irradiation (TLI) alone, and CSA in combination with TLI in a primate segmental pancreatic allotransplantation model. Continous administration of CSA 25 mg/kg/day and 50 mg/kg/day resulted in mean graft survival of 21.5 days and 24.5 days, respectively. Administration of fractionated TLI 800 rad (8 Gy) and 1,000 rad (10 Gy) alone resulted in mean graft survival of 13.3 days and 14.5 days, respectively. Of 20 animals that received TLI 1,000 rad (10 Gy) and CSA 25 mg/kg/ day orally for 5 days then 10 mg/kg/day intramuscularly indefinitely, 3 had graft survival of > 100 days. likewise, of a group of 15 animals that received TLI 800 rad (8 Gy) and combined indefinite administration of CSA, 6 had graft survival of > 100 days. Although CSA and TLI administration alone produced modest panceratic allograft survival, a combination of IL 1 (800 or 1,000 rad) and CSA resulted in highly significant segmental pancreatic allograft survival in the primate.
Prognostic significance of estrogen and progesterone receptors in stage ii breast cancer
Authors: Rydén Stefan , Fernö Mårten , Borg Åke , Hafström Larsolof , Möller Torgil , Norgren Allan 
Published: February 2007

AbstractEstrogen (ER) and progesterone receptors (PgR) were evaluated in samples from primary tumors in 539 patients with stage II breast cancer participating in a randomized multicenter controlled clinical trial on adjuvant therapy. At the cut‐off points of 10 fmol ER/mg protein and 30 fmol PgR/mg protein, no significant difference in recurrence‐free survival (RFS) existed between premenopausal patients with receptor‐positive and negative tumors, respectively. After recurrence, premenopausal patients with receptor‐positive tumors had a significant longer survival than patients with receptor‐negative tumors. In postmenopausal patients not treated with adjuvant tamoxifen, no correlations between RFS and receptor status were found. Patients with ER + tumors survived longer than patients with ER–tumors. In postmenopausal patients treated with adjuvant tamoxifen, highly significant differences in RFS and in survival were observed when receptor‐positive patients were compared with receptor‐negative patients. No differences in survival after recurrence were registered among these patients.
Biochemical and ultrastructural differences between muco‐epidermoid and carcinoid tumors of the bronchus
Authors: Feldman Jerome M. , Benning Timothy L. , Saltzman Herbert 
Published: February 2007

AbstractBronchial adenomas have been classified into three types: carcinoid tumors, cylindromas (adenoid cystic carcinomas), and mucoepidermoid tumors. Studies from our laboratory have demonstrated that the quantitative measurement of monoamine oxidase (MAO) in homogenates of carcinoid tumors of foregut origin is different than the activity enzymes in other tumors of neural crest origin. In this study we compared the biochemical composition of 12 bronchial carcinoid tumors with the biochemical composition of a rare mucoepidermoid adenoma of the bronchus. Electron microscopy revealed that some cells of the mucoepidermoid adenoma contained mucin and tonofilaments; none of the cells contained neurosecretory granules. The MAO activity of the bronchial carcinoid tumors was much higher than the MAO activity of the mucoepidermoid adenoma. Thus, there are distinctive ultrastructural and biochemical differences in these two types of bronchial adenomas.
Germ cell tumors in Indian children
Authors: Khanna Sushila , Arya N. C. , Gupta I. M. , Gupta Saroj , Singhal G. D. 
Published: February 2007

AbstractThe present paper is a retrospective study of one hundred and thirty five germ cell tumors seen in children at the University Hospital, Varanasi during a period of 21 years. These tumors constituted 7.5% of all solid tumors in the pediatric age group. Histologically 89 tumors (65.9%) were benign and 46 (34.1%) were malignant. Eighty percent of ovarian and all the testicular germ cell tumors were malignant. Thirty per cent of the tumors were located in the sacrococcyx. The ovaries were the next common site. There were 80 girls, 53 boys, and 2 cases in which the sex was not recorded. The predominance amongst girls was mainly due to the more frequent involvement of ovaries as compared to the testes. Twenty nine of the children were in the first year of life. The factors probably responsible for the higher incidence of malignancy, the differences in anatomic location, and the sex distribution in comparison to other reports have been examined and discussed.
Correlation of estrogen receptor protein and carcinoembryonic antigen with lymphnodal metastasis in breast carcinoma
Authors: Khemani Anil K. , Kapila Kusum , Sundaram K. R. , Verma Kusum 
Published: February 2007

AbstractEstrogen receptor protein (ERP) content and carcinoembryonic antigen (CEA) positivity were analysed in 50 cases of primary breast carcinoma. Relationship of pathological features known to be of prognostic significance and combined CEA and ERP status were examined. It was found that CEA + ERP − tumours had significantly higher frequency of axillary lymphnodal metastasis in comparison to CEA − ERP + cases. Presence of CEA − or ERP + status showed significant lower frequency of metastasis in comparison to CEA + ERP − tumours.
Experimental continent diversion
Authors: Drago Joseph R. , Nesbitt John A. , Dowell Gladstone Mc , Cirulli Christopher , Geraniotis Evangelos , Smith Jeffrey 
Published: February 2007

AbstractUrinary diversion utilizing a continence‐maintaining ileal valve has been performed in 12 canines. This procedure offers a simple surgical procedure and uses the diversion's internal fluid pressure to maintain continence. Of 12 canines with this continence‐maintaining ileal valve, 11 remained continent at sacrifice. Operative complications were minimal and late complications occurred in 2 dogs. Histological evaluation of the diversionary tissues revealed slight changes in the mucosa of the ileal valve, with some flattening of the villi. This procedure may have a clinical role in urinary diversion for patients with pelvic malignancy or patients who need urinary diversion for other reasons.
Evaluation of N‐acetylneuraminic acid, carcinoembryonic antigen, and alpha‐fetoprotein as markers for advanced carcinoma
Authors: Khanderia Ujjaini , Grossman H. Barton 
Published: February 2007

AbstractSialic acid (N‐acetylneuraminic acid, NANA), carcinoembryonic antigen (CEA), and alpha‐fetoprotein (AFP) were measured in a group of patients with advanced carcinoma (primarily colorectal). The percent change of NANA was less than that with CEA, and more reliably separated patients with stable disease from those with tumor regression or progression. AFP was a good predictor of clinical course in the few patients in which it was measured.
Focal intestinal heating with regional abdominal hyperthermia
Authors: Spanos William J. , Thrasher Thais , Thompson Joe , Torrey Robert R. 
Published: February 2007

AbstractThe effect of regional abdominal heating on the small and large bowel was evaluated in three female research pigs. The BSD Annular Phased Array was used for heating. Blind‐end catheters and a free peritoneal probe were surgically attached to small bowel, large bowel, liver, and kidney. Each pig underwent 4–8 heating sessions and was subsequently autopsied. There was no histologic evidence of acute bowel, liver, or kidney damage. There were significant differences in temperatures at the various sites. The average small bowel temperature was significantly higher than predicated by the free peritoneal probe or than seen in the liver or kidney. The large bowel temperatures averaged higher than the free peritoneal probe temperatures, but the difference was not significant. Liver and kidney temperatures approximate whole body temperature due to extensive vascular network. Although the elevated small bowel temperatures may be due in part to different position in relation to isotherms, the frequent occurrence of a large temperature difference suggests focal heating of fluid pockets in the small bowel.
A new site for totally implanted central venous access system in patients with malignancy: Long‐term results of 10 cases
Authors: Appelqvist P. , Pantzar P. 
Published: February 2007

AbstractIn this study of 10 patients with central venous access system, the reservoir body was implanted in the lower limb. Only one complication was observed per 1,560 days of function time. The anterolateral distal half of the thigh is a good alternative site for the injection port in cancer patients whose jugular veins and veins in the arms are not available owing to a tumour or previous treatments.
Hematoporphyrin derivative uptake and photodynamic therapy in pancreatic carcinoma
Authors: Schroder Tom , Chen I‐Wen , Sperling Matthew , Bell Richard H. , Brackett Kim , Joffe Stephen N. 
Published: February 2007

AbstractLittle information is currently available concerning the uptake of porphyrins by pancreatic tumors, or the effect of photodynamic therapy (PDT) on pancreatic cancer. In Syrian golden hamsters (n = 33), the organ distribution of 125I‐labeled dihematoporphyrin ether (DHE) was studied in a pancreatic cancer model. In the same animal model the effect of PDT was studied using a gold vapor laser for energy delivery 3 hr after the injection of DHE (n = 7). DHE was 2.4 times more concentrated in the pancreatic tumor than in the nontumorous pancreas at 3 hr. Simultaneously there was a considerable accumulation of DHE in the surrounding gastrointestinal tract, causing perforation of the duodenum and jejunum with resultant death in four (57%) animals after PDT. Photodynamic therapy caused extensive tumor necrosis without any obvious effect on the nontumor‐bearing pancreas. Damage to the surrounding tissue in the hamster indicates that precautions should be taken if PDT is to be used clinically in pancreatic cancer. Intratumoral injection of DHE may give higher drug concentrations with greater specificity for tumor treatment.
Factors influencing survival in 242 cases of primary gastric carcinoma
Authors: Secco G. B. , Fardelli R. , Campora E. , Rovida S. , Percivale P. L. 
Published: February 2007

AbstractTwo hundred and forty‐two patients who underwent curative surgery for primary gastric cancer between 1965 and 1979 were reviewed, and the influence on survival of the type of surgical treatment, primary tumor location, operative mortality, and stage of disease was analyzed. Operative mortality was significantly increased in patients with multicentric primaries compared to all other sites (P < 0.001) and in patients undergoing total gastrectomy versus subtotal gastric resection (P < 0.001). Stage III‐IV lesions had a significantly worse prognosis than stage I–II tumors (P < 0.001). Our data confirm that early diagnosis could lead to increased survival.
The immunological aspects of keloid tumor formation
Authors: Kazeem A. A. 
Published: February 2007

AbstractThis study considered possible immunological alterations that may be associated with keloid tumor formation. Laser immunonephelometry was used to quantitate circulating immune complexes and complement C3 and C4 among keloid formers. IgG complex level was significantly higher, while C3 and C4 were lower, than in the control population. The raised IgG was positively correlated with C4 (r = 0.15). When considered with reports of earlier workers, keloid genesis could result from genetic predisposition, environmental trigger, or localized and systemic immune complex formations. The relationship of these factors to a disequilibrium between fibroblast synthesis of collagen and turnover degradation still remains unclear.
Cure of advanced gastric cancer by combined chemotherapy with cisplatinum, mitomycin C, and 5‐fluorouracil
Authors: Tanemura Hiromi , Kawata Ryo , Suzuki Masao , Shimokawa Kuniyasu , Azuma Shuji , Furuta Tomohiko , Saji Shigetoyo , Ohashi Hirofumi , Sakata Kazuki 
Published: February 2007

AbstractA 55‐year‐old female, in which an unresectable Borrmann II‐type gastric cancer (moderately differentiated adenocarcinoma) extending from vicinity of the cardia to the lower portion of the corpus, with direct invasion into the pancreas and extensive lymph node metastases, confirmed by laparotomy, was treated postoperatively by 3 courses of chemotherapy with cisplatinum in combination with mitomycin C and 5‐fluorouracil. A complete response was confirmed by roentgenography and endoscopy, and, at 4 months after the first operation, a total gastrectomy with radical lymphadenectomy was performed successfully. Cancer cells were not detectable histologically in the stomach specimen and in all the lymph nodes removed. One year and 5 months after the second operation she is well, showing no sign of recurrence.
Plasma thromboxane A2 and prostacyclin concentrations in squamous cell carcinoma of the head and neck
Authors: Slotman Gus J. 
Published: February 2007

AbstractCirculating prostaglandins, including thromboxane A2 and prostacyclin, have been implicated as possible facilitative agents in the growth and dissemination of squamous cell carcinomas of the head and neck. The purpose of this study was to evaluate the relationship of plasma concentrations of these compounds to tumor stage and the effect of surgical resection on plasma prostaglandin levels. Blood samples were obtained from 40 patients with head and neck cancer. Ten treated patients were clinically disease‐free (NED), and 30 patients with active disease were previously untreated at the time of this study. Plasma concentrations of thromboxane A2 and prostacyclin were measured by radioimmunoassay of their stable metabolites thromboxane B2 (TxB) and prostaglandin 6‐keto‐F1 (PGI). Platelet aggregation was performed with normal donor platelets (PRP) and normal control or patient plasma (PPP). TxB and TxB/PGI ratios were increased in T1N0M0 patients, compared with NED and with T4N0M0 primary lesions versus all other groups. With lymphatic and hematogenous metastases, TxB and TxB/PGI ratios fell to NED levels. ADP‐induced platelet aggregation was significantly increased in head and neck cancer patients, compared with normal controls, and with T4N0M0 lesions, compared with NED. There were no significant differences in PGI levels. TxB, PGI, TxB/PGI, and platelet aggregometry did not change significantly with curative surgery. TxB and TxB/PGI interactions are involved in head and neck cancer. Changes in TxB and TxB/PGI may be related to increased platelet aggregation.
Primary lymphoma of the head of the pancreas
Authors: Shtamler Benjamin , Bickel Amitai , Manor Eli , Shahar Menachem Ben , Kuten Abraham , Suprun Harry 
Published: February 2007

AbstractPrimary and isolated lymphoma of the head of pancreas with secondary involvement of the lungs and obstructive jaundice, in a 31‐year‐old post‐partum woman, is described. The histological diagnosis was diffuse histiocytic lymphoma. Chemotherapeutic treatment resulted in complete remission of the tumor. During therapy a pseudocyst of the pancreas developed and a gastrocystostomy was performed. This is the second reported case of primary pancreatic lymphoma in the English medical literature.
The pentagastrin test as an indicator of a cure in surgically treated patients with advanced carcinoid disease
Authors: Ahlman H. , Nilsson O. , Dahlström A. , Tisell L.‐ E. 
Published: February 2007

AbstractA unique case of midgut carcinoid with advanced disease, engaging lymphnodes and liver but still accessible to curative surgery, is reported. Besides elevated urinary levels of 5‐hydroxyindoleacetic acid, the diagnosis was based on a positive provocation test with pentagastrin, i.e., basally elevated levels of serotonin in peripheral whole blood increased twofold 3 min postinjection related to the appearance of carcinoid symptoms. After removal of primary and secondary lesions in a two‐step procedure carcinoid symptoms disappeared completely. Biochemically, urinary excretion of 5‐hydroxyindoleacetic acid and serotonin levels in peripheral blood before and during provocation with pentagastrin were both normalized after surgery and have remained so during 27 months of follow‐up. Computed tomographies of the abdomen at regular intervals do not indicate recurrent disease. Histologically, the carcinoid lesions displayed a mixed growth pattern and signs of local aggressiveness. Immunocytochemically, the majority of the tumour cells (positive against neuron specific enolase) showed a positive reaction with serotonin antisera. Substance P‐like immunoreactivity was also found in a large proportion of these cells.
Expression of the human transferrin receptor in subrenal capsule assay in the mouse
Authors: Lindholm Marja‐Liisa , Lindberg Lars‐Axel , Vilja Pekka , Puolakka Veli‐Matti , Nordling Stig , Schröder Tom , Schröder Jim 
Published: February 2007

AbstractThe expression of a cell proliferation marker, the human transferrin receptor, was studied in ten human gastrointestinal tumors prior to and after implantation under the renal capsule in the mouse (1–6 days). These data were compared to the increase in tumor size in situ, and to the infiltration of inflammatory cells. All tumors studied expressed the transferrin receptor prior to implantation. Forty of 47 implants expressed the receptor, the strongest expression occurring on day 4, accompanied by a reorganization of tumor tissue to a morphology similar to that before implantation. On days 5 and 6 the expression of the transferrin receptor declined. Implants showed maximal increase in size on days 1 and 2, decreased in size on days 3 and 4, and increased again on days 5 and 6. The increase in the size of the implants on days 5 and 6 was accompanied by considerable infiltration of inflammatory cells, and was probably mostly a result of invading host cells and inflammation. If size alone is used as a criterion for tumor proliferation in this subrenal capsule assay, day 4 seems to be the most appropriate for evaluation. This is supported by a strong expression of a proliferation marker, the human transferrin receptor, during this time.
Postoperative radiation as adjuvant treatment for carcinoma of the oral cavity larynx, and pharynx: Preliminary report of a prospective randomized trial
Authors: Kokal William A. , Neifeld James P. , Eisert Donald , Lipsett James A. , Lawrence Walter , Beatty J. David , Parker George A. , Pezner Richard D. , Riihimaki Daniel U. , Terz Jose J. 
Published: February 2007

AbstractA prospective randomized trial was performed in patients with advanced squamous cell carcinomas (SCC) of the oral cavity, larynx, and pharynx to examine the effect of adjuvant postoperative radiation therapy on locoregional recurrence and survival following “curative” resection. Fifty‐one patients with stage III or IV SCC treated from 1981 through 1984 were randomized to receive either surgery alone (n = 27) or surgery with postoperative radiation (n = 24). Five patients were excluded from the study after randomization because of ineligibility or protocol violations. Overall recurrence rates of 55.6% and 36.8% were noted in the surgery and surgery with adjuvant radiotherapy arms, respectively (p = NS). This trend towards a higher recurrence rate in the surgery only arm was in part due to the development of lymph node metastases in the contralateral, nonoperated neck. Thus far, no significant differences in either locore‐gional or overall survival have been noted between the two treatment arms. In this preliminary analysis, adjuvant postoperative radiotherapy does not appear to improve disease‐free or overall survival.
Endoscopic surveillance of patients following a curative resection for colorectal cancer
Authors: Md Goran Carlsson , Petrelli Nicholas J. , Herrera Lemuel , Nava Hector , Mittelman Arnold 
Published: February 2007

AbstractFrom 1974 to 1985, 161 patients were followed by at least one colonoscopy following a polypectomy for an adenomatous polyp. These patients had had a previous curative resection performed for colorectal carcinoma. The median follow‐up time after surgery was 54 months. A polyp within 65 cm from the anal verge or from a permanent colostomy was considered detectable by the flexible sigmoidoscope. Seventy‐one patients (44%) were found to have adenomatous polyp(s) within 65 cm during the followup period. This incidence was influenced by the type of colorectal resection performed. In 36 of 41 patients (88%) undergoing a right hemicolectomy, the adenomatous polyp(s) was found within 65 cm from the anal verge. This was an incidence statistically and significantly higher than the incidence in patients undergoing other types of surgical resections. There were no differences in age, sex, or Dukes' stages according to the type of surgical resection performed. In summary, the present study demonstrates that there is a role for postoperative surveillance by the 65 cm flexible sigmoidoscope. This surveillance can be performed with great safety especially in patients following a right hemicolectomy; significantly more of these patients have adenomatous polyps within reach of the 65 cm flexible sigmoidoscope.