bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementing a Staff‐Led Smoking Cessation Intervention in a Diverse Safety‐Net Rheumatology Clinic: A Pre‐Post Scalability Study in a Low‐Resource Setting
Authors: Brandt Jennifer , Ramly Edmond , Lim S. Sam , Bao Gaobin , Messina Monica L. , Piper Megan E. , Bartels Christie M. 
Published: April 2024

ObjectiveQuit Connect (QC), our specialty clinic smoking cessation intervention, supports clinic staff to check, advise, and connect willing patients to a state quit line or class. QC improved tobacco screening and quit line referrals 26‐fold in a predominantly White academic health care system population. Implementing QC includes education, electronic health record (EHR) reminders, and periodic audit feedback. This study tested QC's feasibility and impact in a safety‐net rheumatology clinic with a predominantly Black population.MethodsIn this pre‐post study, adult rheumatology visits were analyzed 12 months before through 18 months after QC intervention (November 2019 through November 2021, omitting COVID‐19 peak April through November 2020). EHR data compared process and clinical outcomes, including offers, referrals to resources, completed referrals, and documented cessation. Clinic staff engaged in pre‐post focus groups and questionnaires regarding intervention feasibility and acceptability. Cost‐effectiveness was also assessed.ResultsVisit‐level patients who smoked were 89.8% Black and 69.5% women (n = 550). Before intervention, clinic staff rarely asked patients about readiness to cut back smoking (<10% assessment). After QC intervention, staff assessed quit readiness in 31.8% of visits with patients who smoked (vs 8.1% before); 58.9% of these patients endorsed readiness to cut back or quit. Of 102 accepting cessation services, 37% (n = 17) of those reached set a quit date. Staff found the intervention feasible and acceptable. Each quit attempt cost approximately $4 to $10.ConclusionIn a safety‐net rheumatology clinic with a predominantly Black population, QC improved tobacco screening, readiness‐to‐quit assessment, and referrals and was also feasible and cost‐effective.image
Time Resolved Cryo‐Correlative Light and Electron Microscopy
Authors: Szabo Gréta V. , Burg Thomas P. 
Published: April 2024

AbstractComplex materials exhibit fascinating features especially in situations far from equilibrium. Thus, methods for investigating structural dynamics with sub‐second time resolution are becoming a question of interest at varying spatial scales. With novel microscopy techniques steadily improving, the temporal and spatial limits of multiple imaging methods are investigated with an emphasis on the important role of correlative imaging and cryo‐fixation. A deep‐dive is taken into cryo‐correlative light and electron microscopy (CLEM) as a starting point for multimodal investigations of ultrastructural dynamics at high spatiotemporal resolution. The focus is on highlighting the different microscopy methods that capture the following key aspects: 1) samples are as close to native state as possible 2) dynamic process information is captured, 3) high structural resolution is enabled. Additionally, the size of samples that can be imaged under these conditions is looked at and approaches not only focusing on single molecules, but larger structures are highlighted.
Robust Macroscale Superlubricity in Humid Air via Designing Amorphous DLC/Crystalline TMDs Friction Pair
Authors: Zhu Dongxiang , Zhang Jie , Li Panpan , Li Zhan , Li Hongxuan , Liu Xiaohong , Ma Tianbao , Ji Li , Zhou Huidi , Chen Jianmin 
Published: April 2024

AbstractSuperlubricity, a cutting‐edge concept, has the potential to drive the Fourth Industrial Revolution giving its near‐zero energy consumption, but the challenge is how to achieve it in humid air with chemical activity and at macroscale surfaces with unavoidable defects. Here, a novel principle involving the amorphous/crystalline friction pair based on the cognition that tribochemical interaction sites originate from grain boundary defect locations is proposed to achieve macroscale superlubricity in humid air. The absence of grain boundaries in amorphous diamond‐like carbon (DLC) significantly reduces chemical interaction during the sliding process. This is supported by experimental observations of priority oxidation at the grain boundaries. Results indicate DLC versus MoS2 friction pair has weakened chemical interaction and less humid insensitivity compared to the MoS2 versus MoS2 pair, even increasing the contact area. Theoretical simulation suggests that DLC versus MoS2 pair eliminates the cross‐linking of friction interlayers induced by the enrichment of H2O molecules at MoS2 defects. The robust superlubricity is achieved for the typical friction pair of DLC versus MoS2 in air (RH≤25%) at macroscopic contact pressure (1.1 GPa) with friction coefficient in 10−3 magnitude and extra‐long anti‐wear life (more than 2 × 105 cycles), which is of significance for the industrialization of superlubricity.
Core@paratroopers Nanoassemblies with Catalytic Cascade for Efficient Tumor Starvation Therapy
Authors: Lu Qianqian , Hou Mengmeng , Huang Xirui , Yu Hongyue , Li Xingjin , Jia Jia , Zhou Qiaoyu , Lv Kexin , Ren Tingting , Liu Minchao , Zhan Yating , Kou Yufang , Dong Lingkai , Zhao Tiancong , Li Xiaomin 
Published: April 2024

AbstractThe catalytic therapy based on the nanozymes has received increasing interest in cancer treatment. However, the catalytic capabilities of standalone nanozymes are relatively limited, necessitating the development of a nano‐bio composite system that integrates both nanozymes and natural enzymes. This construction often inevitably leads to interference between natural enzyme and nanozymes, resulting in reduced synergistic performance. Herein, a cascade catalysis system featuring the “core@paratroopers” structure is proposed, wherein hollow manganese dioxide (HMnO2) serves as “core” and ultra‐small hybrid single‐micelle (H‐micelle) encapsulated with glucose oxidase (GOx) as “paratroopers” (H‐micelle‐GOx). The outer SiO2 layer of the H‐micelle can effectively protect the GOx. Under hypoxic conditions, HMnO2 reacts with endogenous H2O2 to produce O2, thereby enhancing the catalytic efficiency of GOx for starvation therapy. Simultaneously, the generated H2O2 boosts the catalytic efficiency of HMnO2, accelerating local O2 generation and alleviating tumor hypoxia. Additionally, this system exhibits rapid degradation in the tumor microenvironment characterized by high glutathione (GSH) expression, facilitating the release and deep penetration of the ultra‐small H‐micelle‐GOx “paratroopers” within the solid tumor.
Erbium‐Induced Boost in Self‐Trapped Exciton Emission of Double Perovskites for Highly Sensitive Multimodal and Multiplexed Optical Thermography
Authors: Li Gaoqiang , Cheng Shanshan , Chen Xu , Wang Meng , Zhang Fei , Chen Zhipeng , Liang Yurun , Li Xu , Ji Huifang , Yang Dongwen , Han Yanbing , Li Xinjian , Xu Wen , Jia Mochen , Shan Chongxin , Shi Zhifeng 
Published: April 2024

AbstractSelf‐trapped excitons (STEs) of lead‐free perovskites have aroused tremendous interest in remote optical thermometry due to strong exciton–phonon coupling and large Stokes shifts. Herein, a bright multimodal and multiplexed optical thermometer is constructed with high sensitivity (Sr) and self‐calibrating ability based on Cs2NaInCl6:Er3+ double perovskite, allowing for fast and simplified reading via mobile devices. Intriguingly, Er3+ doping not only shows the characteristic green emissions but also introduces nanoelectronic domains through a new localized valance band maximum and breaks the symmetry of In3+ site, which facilitates the generation of more STEs. The temperature‐sensitive blue emission of STEs and temperature‐insensitive green emission of Er3+ endow multimodal optical thermometry including time‐resolved and ratiometric readout schemes with a maximum Sr of 3.8% K−1, where an upconversion primary thermometry serves as a reference to calibrate other modes. Meanwhile, the designed thermometers show robust photostability, repeatability, and structural stability for long‐time working and storage. In addition, the remarkable thermochromic phenomenon from blue to green enables a quick color‐multiplexed thermography on a smartphone, which is utilized to capture real‐time 2D thermal imaging of microelectronic devices. This work demonstrates the great potential of lead‐free double perovskite for low‐cost and portable optical thermometry.
High‐Performance Self‐Powered Flexible Thermoelectric Device for Accelerated Wound Healing
Authors: Zhang Yuwei , Ge Bangzhi , Feng Jianghe , Kuang Nianling , Ye Haolin , Yuan Ziling , Wu Mengyue , Jiang Binbin , Li Juan , Sun Qiang , Niu Lin , Zhu Menghua , Xu Yadong , Jie Wanqi , Liu Ruiheng , Dong Shaojie , Zhou Chongjian 
Published: April 2024

AbstractElectric signal accelerates full‐thickness wound healing in the clinic, which is usually generated by a large power generation system and requires delicate control by authorized personnel. Here, a self‐powered flexible and biocompatible thermoelectric device with exceptionally high power generation efficiency is developed. It generates 10 mV voltage at a temperature gradient of 10 K, outperforming all reported flexible thermoelectric devices. Accordingly, it can directly and efficiently convert the omnipresent heat in the skin to electricity at the microvolt level. The output electricity activates and upregulates the expression of Piezo1‐mediated pathways that are associated with tissue regeneration, accelerating the cell migration and proliferation in vitro and healing the wound 4 days faster in vivo. Importantly, the thermoelectric device fast‐heals the wound without involving any additional electric circuit such as an amplifier. These advantages will revolutionize the designing of self‐powered wearable bioelectronics for diagnosing, monitoring, and treating various pathological conditions employing the skin heat.
Cuproptosis: Advances in Stimulus‐Responsive Nanomaterials for Cancer Therapy
Authors: Lu Jiacheng , Miao Yuqing , Li Yuhao 
Published: April 2024

AbstractCuproptosis, a recently identified non‐apoptotic programmed cell death modality, attracts considerable attention in the realm of cancer therapeutics owing to its unique cellular demise mechanisms. Since its initial report in 2022, strategies inducing or amplifying cuproptosis for cancer treatment emerge. The engineering of nano‐systems to elicit cuproptosis effectively circumvents constraints associated with conventional small‐molecule pharmaceutical interventions, presenting novel prospects for oncological therapy. Stimulus‐responsive nanomaterials, leveraging their distinctive spatiotemporal control attributes, are investigated for their role in modulating the induction or augmentation of cuproptosis. In this comprehensive review, the physiological characteristics of cuproptosis, encompassing facets such as copper overload and depletion, coupled with regulatory factors intrinsic to cuproptosis, are expounded upon. Subsequently, design methodologies for stimulus‐responsive induction or enhancement of cuproptosis, employing stimuli such as light, ultrasound, X‐ray, and the tumor microenvironment, are systematically delineated. This review encompasses intricacies in nanomaterial design, insights into the therapeutic processes, and the associated advantages. Finally, challenges inherent in stimulus‐responsive induction/enhancement of cuproptosis are deliberated upon and prospective insights into the future trajectory of copper‐mediated cancer therapy are provided.
Crystal‐Phase‐Engineered High‐Entropy Alloy Aerogels for Enhanced Ethylamine Electrosynthesis from Acetonitrile
Authors: Huang Honggang , Chen Cun , Chang Chun‐Chi , Lai Feili , Liu Shangheng , Fu Hui , Chen Yao , Li Hanjun , Huang Wei‐Hsiang , Zhang Nan , Liu Tianxi 
Published: April 2024

AbstractCrystal‐phase engineering that promotes the rearrangement of active atoms to form new structural frameworks achieves excellent result in the field of electrocatalysis and optimizes the performance of various electrochemical reactions. Herein, for the first time, it is found that the different components in metallic aerogels will affect the crystal‐phase transformation, especially in high‐entropy alloy aerogels (HEAAs), whose crystal‐phase transformation during annealing is more difficult than medium‐entropy alloy aerogels (MEAAs), but they still show better electrochemical performance. Specifically, PdPtCuCoNi HEAAs with the parent phase of face‐centered cubic (FCC) PdCu possess excellent 89.24% of selectivity, 746.82 mmol h−1 g−1cat. of yield rate, and 90.75% of Faraday efficiency for ethylamine during acetonitrile reduction reaction (ARR); while, maintaining stability under 50 h of long‐term testing and ten consecutive electrolysis cycles. The structure–activity relationship indicates that crystal‐phase regulation from amorphous state to FCC phase promotes the atomic rearrangement in HEAAs, thereby optimizing the electronic structure and enhancing the adsorption strength of reaction intermediates, improving the catalytic performance. This study provides a new paradigm for developing novel ARR electrocatalysts and also expands the potential of crystal‐phase engineering in other application areas.
Handedness‐Inverted and Stimuli‐Responsive Circularly Polarized Luminescent Nano/Micromaterials Through Pathway‐Dependent Chiral Supramolecular Polymorphism
Authors: Zhao Chenyang , Wang Yuan , Jiang Yuqian , Wu Ningning , Wang Hanxiao , Li Tiejun , Ouyang Guanghui , Liu Minghua 
Published: April 2024

AbstractThe precise manipulation of supramolecular polymorphs has been widely applied to control the morphologies and functions of self‐assemblies, but is rarely utilized for the fabrication of circularly polarized luminescence (CPL) materials with tailored properties. Here, this work reports that an amphiphilic naphthalene‐histidine compound (NIHis) readily self‐assembled into distinct chiral nanostructures through pathway‐dependent supramolecular polymorphism, which shows opposite and multistimuli responsive CPL signals. Specifically, NIHis display assembly‐induced CPL from the polymorphic keto tautomer, which become predominant during enol‐keto tautomerization shifting controlled by a bulk solvent effect. Interestingly, chiral polymorphs of nanofiber and microbelt with inverted CPL signals can be prepared from the same NIHis monomer in exactly the same solvent compositions and concentrations by only changing the temperature. The tunable CPL performance of the solid microbelts is realized under multi external physical or chemical stimuli including grinding, acid fuming, and heating. In particular, an emission color and CPL on–off switch based on the microbelt polymorph by reversible heating–cooling protocol is developed. This work brings a new approach for developing smart CPL materials via supramolecular polymorphism engineering.
High Strain Engineering of a Suspended WSSe Monolayer Membrane by Indentation and Measured by Tip‐Enhanced Photoluminescence
Authors: Chiout Anis , Tempez Agnès , Carlier Thomas , Chaigneau Marc , Cadiz Fabian , Rowe Alistair , Zheng Biyuan , Pan Anlian , Pala Marco , Oehler Fabrice , Ouerghi Abdelkarim , Chaste Julien 
Published: April 2024

AbstractStraintronics involves the manipulation and regulation of the electronic characteristics of 2D materials through the use of macro‐ and nano‐scale strain engineering. In this study, an atomic force microscope (AFM) coupled with an optical system is used to perform indentation measurements and tip‐enhanced photoluminescence (TEPL), allowing to extract the local optical response of a suspended monolayer membrane of ternary WSSe at various levels of deformation, up to strains of 10%. The photoluminescence signal is modeled considering the deformation, stress distribution, and strain dependence of the WSSe band structure. An additional TEPL signal is observed that exhibits significant variation under strain, with 64 meV per percent of elongation. This peak is linked to the highly strained 2D material lying right underneath the tip. The amplification of the signal and its relation to the excitonic funneling effect are discussed in a more comprehensive model. The diffusion caused by Auger recombination against the radiative excitonic decay will also be compared. TEPL is used to examine and comprehend the local physics of 2D semi‐conducting materials subjected to extreme mechanical strain. Chemical vapor deposition‐fabricated 2D ternaries possess high strain resistance, comparable to the benchmark MoS2, and a high Young's modulus of 273 GPa.
Chitosan Composite Membrane with Efficient Hydroxide Ion Transport via Nano‐Confined Hydrogen Bonding Network for Alkaline Zinc‐Based Flow Batteries
Authors: Hu Jing , Wang Pengfei , Hu Jianbo , Zheng Menglian , Dong Mingdong 
Published: April 2024

AbstractThe development of membranes with rapid and selective ionic transport is imperative for diverse electrochemical energy conversion and storage systems, including fuel cells and flow batteries. However, the practical application of membranes is significantly hindered by their limited conductivity and stability under strong alkaline conditions. Herein, a unique composite membrane decorated with functional Cu2+ cross‐linked chitosan (Cts‐Cu‐M) is reported and their high hydroxide ion conductivity and stability in alkaline flow batteries are demonstrated. The underlying hydroxide ions transport of the membrane through Cu2+ coordinated nano‐confined channels with abundant hydrogen bonding network via Grotthuss (proton hopping) mechanism is proposed. Consequently, the Cts‐Cu‐M membrane achieves high hydroxide ion conductivity with an area resistance of 0.17 Ω cm2 and enables an alkaline zinc‐based flow battery to operate at 320 mA cm−2, along with an energy efficiency of ≈80%. Furthermore, the membrane enables the battery for 200 cycles of long‐cycle stability at a current density of 200 mA cm−2. This study offers an in‐depth understanding of ion transport for the design and preparation of high‐performance membranes for energy storage devices and beyond.
Is there an association between proficiency in fundamental movement skills and moderate‐to‐vigorous physical activity in childhood on weekdays and weekends? The REACT project
Authors: Garbeloto Fernando , Maia José , Barreira Tiago V. , Hedeker Donald , Chaput Jean‐Philippe , Garganta Rui , Farias Cláudio , Santos Ricardo , Stodden David F. , Tani Go , Katzmarzyk Peter T. , Pereira Sara 
Published: April 2024

AbstractObjectiveThe present study probes into the association between children's fundamental movement skills (FMS) and moderate‐to‐vigorous physical activity (MVPA) during weekdays and weekends.MethodsThis cross‐sectional sample included 1014 children aged 6–10 years from the REACT project. Physical activity was assessed with accelerometry, and five FMS (stationary dribble, kick, catch, overhand throw, and underhand roll) were assessed with the digital platform Meu Educativo®. Three groups were formed based on the frequency of FMS that each child mastered: group 1 (wizard level in four or five FMS); group 2 (wizard level in two or three FMS); and group 3 (wizard level in at most one skill). Multilevel models were used to analyze the data treating children (level‐1) nested within schools (level‐2).ResultsCompared to group 1, groups 2 (−12.9 ± 2.3 min day−1) and 3 (−23.9 ± 2.4 min day−1) were less physically active during weekdays and weekends (group 2: −14.7 ± 2.7 min day−1 and group 3: −22.4 ± 2.9 min day−1), independent of age and sex. There was a decline in MVPA during the weekend. Further, on average, boys were more active than girls, and with increasing age, children were less active.ConclusionOn average, children with higher FMS levels are generally more physically active than their peers with lower FMS levels. Even though MVPA tends to decline on weekends, FMS proficiency is a significant factor in maintaining 60 min of MVPA on weekends.
Longitudinal cerebral perfusion in presymptomatic genetic frontotemporal dementia: GENFI results
Authors: Pasternak Maurice , Mirza Saira S. , Luciw Nicholas , Mutsaerts Henri J. M. M. , Petr Jan , Thomas David , Cash David , Bocchetta Martina , Tartaglia Maria Carmela , Mitchell Sara B. , Black Sandra E. , Freedman Morris , Tang‐Wai David , Rogaeva Ekaterina , Russell Lucy L. , Bouzigues Arabella , van Swieten John C. , Jiskoot Lize C. , Seelaar Harro , Laforce Robert , Tiraboschi Pietro , Borroni Barbara , Galimberti Daniela , Rowe James B. , Graff Caroline , Finger Elizabeth , Sorbi Sandro , de Mendonça Alexandre , Butler Chris , Gerhard Alex , Sanchez‐Valle Raquel , Moreno Fermin , Synofzik Matthis , Vandenberghe Rik , Ducharme Simon , Levin Johannes , Otto Markus , Santana Isabel , Strafella Antonio P. , MacIntosh Bradley J. , Rohrer Jonathan D. , Masellis Mario ,   the GENetic Frontotemporal dementia Initiative (GENFI)
Published: April 2024

AbstractINTRODUCTIONEffective longitudinal biomarkers that track disease progression are needed to characterize the presymptomatic phase of genetic frontotemporal dementia (FTD). We investigate the utility of cerebral perfusion as one such biomarker in presymptomatic FTD mutation carriers.METHODSWe investigated longitudinal profiles of cerebral perfusion using arterial spin labeling magnetic resonance imaging in 42 C9orf72, 70 GRN, and 31 MAPT presymptomatic carriers and 158 non‐carrier controls. Linear mixed effects models assessed perfusion up to 5 years after baseline assessment.RESULTSPerfusion decline was evident in all three presymptomatic groups in global gray matter. Each group also featured its own regional pattern of hypoperfusion over time, with the left thalamus common to all groups. Frontal lobe regions featured lower perfusion in those who symptomatically converted versus asymptomatic carriers past their expected age of disease onset.DISCUSSIONCerebral perfusion is a potential biomarker for assessing genetic FTD and its genetic subgroups prior to symptom onset.Highlights
Gray matter perfusion declines in at‐risk genetic frontotemporal dementia (FTD).
Regional perfusion decline differs between at‐risk genetic FTD subgroups .
Hypoperfusion in the left thalamus is common across all presymptomatic groups.
Converters exhibit greater right frontal hypoperfusion than non‐converters past their expected conversion date.
Cerebral hypoperfusion is a potential early biomarker of genetic FTD.