bluuebunny/crossref_metadata_2025_split huggingface dataset:
Magneto-thermal limitations in superconducting cavities at high radio-frequency fields
Authors: Parajuli I. , Ciovati G. , Gurevich A. 
Published: March 2024

The performance of superconducting radio-frequency Nb cavities at high radio-frequency (rf) fields in the absence of field emission can be limited by either a sharp decrease of the quality factor Q0(Bp) above peak surface magnetic fields Bp ∼100 mT or by a quench. We have measured Q0(Bp) at 2 K of several 1.3 GHz single-cell Nb cavities with different grain sizes, and with different ambient magnetic fields and cooldown rates below the critical temperature. Temperature mapping and a novel magnetic field mapping systems were used to find the location of “hot-spots” and regions of trapped magnetic flux. The use of a variable input coupler allowed further exploring the dissipative state. The results showed a remarkable thermal stability in some cavities with up to 200 W of rf power dissipation at 2 K, whereas other cavities quenched at much lower rf power. We observed a narrow distributions of the onset fields of hot-spots which were not affected by thermal cycling or by conditions which favor the formation of Nb hydrides. Furthermore, a poor correlation was found between the location of hot-spots and trapped vortices. We suggest that the totality of our experimental data can be explained by a sharp increase of the residual surface resistance above 120–140 mT due to the field-induced breakdown of a proximity-coupled metallic suboxide layer at the surface.
Treg cells as a protective factor for Hashimoto`s thyroiditis: a Mendelian randomization study
Authors: Guo Jinzhou , Si Gao , Si Fuchun 
Published: March 2024

Background and objectivesHashimoto’s thyroiditis (HT), a chronic autoimmune disorder impacting thyroid function, is a growing public health concern. The relationship between Treg cells and HT has been extensively studied, with Treg cells considered crucial in suppressing HT progression. However, these studies have mainly been observational, limiting our understanding of Treg cells’ impact on HT risk. Leveraging large datasets, we utilized Mendelian randomization (MR) analysis to examine the causal association between Treg cell biomarkers and HT, providing additional validation for these relationships.MethodsComprehensive two-sample Mendelian randomization analysis was performed to determine the causal association between Treg cells signatures and HT in this study. Based on publicly available genetic data, we explored causal associations between 165 Treg cells signatures and HT risk.ResultsThe European cohort study has identified five Treg cell phenotypes that causally protect against HT risk. Resting Treg %CD4 (OR = 0.975, 95% CI = 0.954~0.998, P = 0.030); CD4 on resting Treg (OR = 0.938, 95% CI = 0.882~0.997, P = 0.041; CD28- CD8dim %CD8dim (OR = 0.983, 95% CI = 0.969~0.998, P = 0.030); CD25 on CD39+ resting Treg (OR = 0.926, 95% CI = 0.864~0.991, P = 0.026); 5) CD28 on activated &amp; secreting Treg (OR = 0.969, 95% CI = 0.942~0.996, P = 0.025). The Asian cohort study has identified four Treg cell phenotypes negatively correlated with the risk of HT. CD25hi %T cell (OR = 0.635, 95% CI = 0.473~852, P = 0.002); CD4 Treg %CD4 (OR = 0.829, 95% CI = 0.687~1.000, P = 0.050); CD127-CD8br %T cell (OR = 0.463, 95% CI =0.311~0.687, P&lt; 0.001); CD3 on resting Treg (OR = 0.786, 95% CI = 0.621~0.994, P = 0.044).ConclusionOur study has demonstrated the close connection between Treg cells and HT by genetic means, thus providing foundational basis for future research.
Association of composite dietary antioxidant index with prevalence of stroke: insights from NHANES 1999-2018
Authors: Teng Tian-Qi , Liu Jing , Hu Fang-Fang , Li Qing-Qing , Hu Zhen-Zhu , Shi Yu 
Published: March 2024

BackgroundThere is a growing acknowledgment of the potential influence of antioxidative effects resulting from dietary decisions on the occurrence of stroke. The objective of this study was to elucidate the correlation between the composite dietary antioxidant index (CDAI) and the incidence of stroke in the general population of the United States.MethodsWe gathered cross-sectional data encompassing 40,320 participants from the National Health and Nutrition Examination Survey (NHANES) spanning the years 1999 to 2018. Employing weighted multivariate logistic regression, we assessed the correlation between CDAI and stroke, while also investigating potential nonlinear relationships through restricted cubic spline (RCS) regression. Further, the intake of CDAI components were then incorporated into a predictive nomogram model, subsequently evaluated for its discriminatory prowess in stroke risk assessment using the receiver operating characteristic (ROC) curve.ResultsPost-adjustment for confounding variables, we found that higher CDAI score were associated with a decreased risk of stroke, the odds ratio (OR) [95% CI] of CDAI associating with prevalence was 0.96 [0.94-0.98] (P&lt; 0.001). Moreover, the adjusted OR [95% CI] for stroke across ascending CDAI quartiles stood at 0.90 [0.74-1.09], 0.74 [0.60-0.91], and 0.61 [0.50-0.76] compared to the reference quartile, respectively. The RCS analysis indicated a nonlinear yet negative correlation between CDAI and stroke. The nomogram model, constructed based the intake of antioxidants, exhibited a significant predictive capacity for stroke risk, boasting an area under the curve (AUC) of 77.4% (76.3%–78.5%).ConclusionOur investigation ascertained a nonlinear negative relationship between CDAI and stroke within the broader American population. However, given the inherent limitations of the cross-sectional design, further comprehensive research is imperative to establish the causative nature of this association.
Detection of Staphylococcus aureus virulence gene pvl based on CRISPR strip
Authors: Jin Li , Hu XiaoFeng , Tian Yuan , Fang MengYa , Dong Xue , Jiang YaXuan , Han Yao , Li Hao , Sun Yansong 
Published: March 2024

IntroductionStaphylococcus aureus (S. aureus) is a prominent pathogen responsible for both hospital-acquired and community-acquired infections. Among its arsenal of virulence factors, Panton-Valentine Leucocidin (PVL) is closely associated with severe diseases such as profound skin infections and necrotizing pneumonia. Patients infected with pvl-positive S. aureus often exhibit more severe symptoms and carry a substantially higher mortality risk. Therefore, it is crucial to promptly and accurately detect pvl-positive S. aureus before initiating protective measures and providing effective antibacterial treatment.MethodsIn this study, we propose a precise identification and highly sensitive detection method for pvl-positive S. aureus based on recombinase-assisted amplification and the CRISPR-ERASE strip which we previously developed.ResultsThe results revealed that this method achieved a detection limit of 1 copy/μL for pvl-positive plasmids within 1 hour. The method successfully identified all 25 pvl-positive and 51 pvl-negative strains among the tested 76 isolated S. aureus samples, demonstrating its concordance with qPCR.DiscussionThese results show that the CRISPR-ERASE detection method for pvl-positive S. aureus has the advantages of high sensitivity and specificity, this method combines the characteristics of recombinase-assisted amplification at room temperature and the advantages of ERASE test strip visualization, which can greatly reduce the dependence on professional laboratories. It is more suitable for on-site detection than PCR and qPCR, thereby providing important value for rapid on-site detection of pvl.
Efficacy and safety of a music-therapy facilitated pulmonary telerehabilitation program in COPD patients: the COPDMELODY study protocol
Authors: Shi Minghui , Yang Lulu , Qumu Shiwei , Lei Jieping , Huang Ke , He Ruoxi , Niu Hongtao , Dong Fen , Wang Siyuan , He Jiaze , Yang Ting 
Published: March 2024

Despite considerable evidence for the benefit in chronic obstructive pulmonary disease (COPD), the implementation of pulmonary rehabilitation (PR) is insufficient. However, music therapy may help address this gap due to its unique benefits. Therefore, we aimed to develop a music-therapy facilitated pulmonary telerehabilitation program based on rhythm-guided walking, singing, and objective telemonitoring. A supervised, parallel-group, single-blinded, randomized controlled clinical trial will be conducted, including 75 patients with COPD anticipated to be randomized in a 1:1:1 ratio into three groups. The intervention groups will receive a 12-week remotely monitored rehabilitation program, while the usual care group will not receive any rehabilitation interventions. Of the two intervention groups, the multi-module music therapy group will contain rhythm-guided walking and singing training, while the rhythm-guided walking group will only include music tempo-guided walking. The primary outcome is the distance of the incremental shuttle walking test. Secondary outcomes include respiratory muscle function, spirometry, lower extremity function, symptoms, quality of life, anxiety and depression levels, physical activity level, training adherence, and safety measurements. The results of this study can contribute to develop and evaluate a home-based music-facilitated rehabilitation program, which has the potential to act as a supplement and/or substitute (according to the needs) for traditional center-based PR in patients with stable COPD.Clinical trial registration: https://classic.clinicaltrials.gov/, NCT05832814.
Application of three-dimensional technology in video-assisted thoracoscopic surgery sublobectomy
Authors: Zhang Xinyu , Yang Di , Li Linqian , Wang Jianing , Liang Si , Li Peng , Han Zhe , Wang Xiaodong , Zhang Ke 
Published: March 2024

BackgroundDue to the widespread use of imaging techniques, the detection rate of early-stage lung cancer has increased. Video-assisted thoracoscopic surgery (VATS) sublobectomy has emerged as a prominent alternative to lobectomy, offering advantages like reduced resection range, better preservation of lung function, and enhanced postoperative quality of life. However, sublobectomy is more intricate than lobectomy, necessitating a higher level of surgical proficiency and anatomical understanding.MethodsThree electronic databases were searched to capture relevant studies from January 2016 to March 2023, which related to the application of three-dimensional(3D) technology in VATS sublobectomy.ResultsCurrently, clinical departments such as orthopedics, hepatobiliary surgery, and urology have started using 3D technology. This technology is expected to be widely used in thoracic surgery in future. Now 3D technology assists in preoperative planning, intraoperative navigation and doctor-patient communication.Conclusion3D technologies, instrumental in locating pulmonary nodules and identifying variations in target lung segmental vessels and bronchi, play pivotal roles in VATS sublobectomy, especially in preoperative planning, intraoperative navigation, and doctor-patient communication. The limitations of 3D technology in clinical application are analyzed, and the future direction of existing 3D technology development is prospected.
An adaptive evacuation system for the Gran Sasso underground laboratory
Authors: Cavalcante Paolo , Bucciarelli Gabriele 
Published: March 2024

The Gran Sasso National Laboratory (LNGS) is, at present, the largest deep underground laboratory in operation for astroparticle physics and rare event research. The LNGS was created to carry out this research exploiting an overburden of 1,400 m of rock to reduce the flux of muons from cosmic rays. Operating an underground laboratory and its facilities implies a high level of risk. To mitigate risks at the LNGS, a crucial aspect is represented by the evacuation of people from an underground environment during emergencies. The connection between the underground facilities and the outside infrastructure is limited, and the intervention by rescue teams is complicated. This paper reports the study of an adaptive evacuation system to improve the evacuation performance in underground laboratories. The system proposed is composed of a combination of passive, dynamic, and adaptive signage that is able to adapt itself to lead the laboratory occupants to the safe location for evacuation (assembly point). The system collects information from all safety plants, and the data are processed using a customized path-finding algorithm. In the computational algorithm, the underground laboratory is represented as a grid, and the customized path-finding algorithm discovers all available paths to reach the identified evacuation assembly point.
Individual differences in environmental sensitivity: associations between cognitive emotion regulation and mental health
Authors: Yano Kosuke , Oishi Kazuo 
Published: March 2024

IntroductionEnvironmental sensitivity is defined as the ability to perceive and process internal and external information. Previous studies have suggested that mental health-related factors differ by sensitivity level. This study aimed to investigate whether environmental sensitivity moderates the associations between cognitive emotion regulation strategies (e.g., rumination and blaming others) and mental health.Materials and methodsIn this three-wave longitudinal study, participants (N = 1,233, 585, and 349 at Times 1, 2, and 3, respectively) completed the Cognitive Emotion Regulation Questionnaire-short and Kessler 10 scale at all the measurement points as well as the 10-item version of the Highly Sensitive Person scale and some covariates only at Time 1.ResultsLatent growth model analyses indicated that the blaming others strategy had contrastive effects on changes in mental health by sensitivity level; the increase in refocusing on planning was associated with improved mental health over time only for highly sensitive individuals; and the rumination and catastrophizing strategies were the most important risk factors for mental health problems, although their effects differed slightly by sensitivity level.ConclusionThe associations between some of the cognitive strategies and mental health differ by environmental sensitivity level. Future investigations based on individual differences in sensitivity could provide innovative insights into practices.
L2 Arabic learners’ processing of Arabic garden-path sentences: a consistent reading pattern
Authors: Alseraye Abdullah M. Seraye 
Published: March 2024

PurposeThe main purpose of this study was to investigate to what extent the L2 Arabic learners’ reading process is affected by the incomplete representation of speech (the absence of short vowels and diacritics) while reading ambiguous sentences (garden path sentences).MethodWith a self-paced reading software program, 41 non-native male students, aged from 22 to 26, enrolled in King Saud University, participated in reading 44 sentences (followed by reading comprehension questions) representing three reading conditions, plain, vowelized-discretized, and wrongly-vowelized.ResultsFor the reading times data, the analysis revealed that the GP structure had a significant effect on the reading processes of L2 Arabic learners; it took them longer to read the GP sentences than their non-GP counterparts. For the reading comprehension, the analysis did not reveal any significant differences between the means for the percentages of correct responses. For the comparison between the three reading conditions, a significant difference was found: it took the participants on average less time to read the GP sentences when presented plain, and more time with the incorrect representation. However, their reading comprehension was not affected.ConclusionIn addition to the good-enough model and the nature of Arabic morphology, the reading experience, is a good candidate to start with as an important factor in the interpretation of the ineffectiveness of the GP structure on the reading comprehension process of Arabic readers, in which the segregability of Arabic writing system prepare the readers to emphasize some sensory inputs and ignore others based on their past reading experience.
Associations between pregnancy loss and common mental disorders in women: a large prospective cohort study
Authors: Shen Qiaoqiao , Zhong Wenfang , Wang Xiaomeng , Fu Qi , Mao Chen 
Published: March 2024

BackgroundIncreasing evidence suggests that pregnancy loss can lead to negative emotional outcomes, such as anxiety and depression, for women. However, limited knowledge exists regarding the long-term risk of mental disorders among individuals who have experienced pregnancy loss.ObjectiveTo investigate the associations between pregnancy loss and the risk of common mental disorders.MethodsIn the UK Biobank, a total of 218,990 women without any mental disorder at baseline were enrolled between 2006 and 2010 and followed until October 2022. Information on the history of pregnancy loss was obtained through self-reported questionnaires at baseline. Cox proportional hazard regression models were used to estimate adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for associations between pregnancy loss and common mental disorders.ResultsDuring a median follow-up time of 13.36 years, there were 26,930 incident cases of common mental disorders. Incidence rates of common mental disorders were elevated among women with a history of stillbirth (HR 1.15, 95% CI: 1.07–1.23), miscarriage (HR 1.06, 95% CI: 1.02–1.10), or pregnancy termination (HR 1.21, 95% CI: 1.17–1.25) compared to those without such experiences. Furthermore, the risk of common mental disorders significantly increased in women with two or more miscarriages (HR 1.14, 95% CI: 1.08–1.19) or two or more pregnancy terminations (HR 1.39, 95% CI: 1.30–1.48).ConclusionsPregnancy loss is associated with an increased risk of common mental disorders in women later in life. These findings may contribute to the enhancement of long-term monitoring and prevention of common mental disorders for women with such a history.
Analysis of preoperative and postoperative depression and anxiety in patients with osteochondral lesions of the talus
Authors: Cao ShiHang , Zan Qiang , Lu Jun , Li Yi , Li BingBing , Zhao Hang , Wang Tao , Xu JunKui 
Published: March 2024

PurposeThis study aims to investigate the psychological status of patients with Hepple V osteochondral lesions of the talus (OLT) and evaluate the effect of autologous osteoperiosteal transplantation (AOPT) on their psychological well-being.MethodsFifty patients with Hepple V OLT who underwent AOPT at the Comprehensive Foot and Ankle Surgery Ward of Xi’an Honghui Hospital from November 2021 to May 2023 were included in this study. The patients were divided into two groups based on the presence or absence of preoperative symptoms of anxiety/depression. Group A comprised patients with preoperative symptoms, while Group B included patients without such symptoms. Preoperative and final follow-up assessments included the Hospital Anxiety and Depression Scale for evaluating anxiety and depression, the visual analogue scale for pain assessment, and the American Orthopaedic Foot and Ankle Society scores for assessing ankle and hindfoot function.ResultsAmong the 50 Hepple V OLT patients who obtained complete follow-up, twenty-four had preoperative symptoms of anxiety/depression, with an incidence rate of up to 48%. Patients in Groups A and B showed significant improvement in all evaluation indexes after AOPT compared to the preoperative period, but the overall prognosis of Group A was poorer than that of Group B.ConclusionAOPT can effectively improve patients’ pain, functional activities, and psychological status, and there is a significant correlation between patients’ preoperative psychological status and prognosis.
Parametric analysis of the transmission dynamics during indigenous aggregated outbreaks caused by five SARS-CoV-2 strains in Nanjing, China
Authors: Ma Tao , Chen Cong , Wang Junjun , Wang Hengxue , Zhao Yueyuan , Zhu Yuanzhao , Yan Zikang , Ding Songning , Ding Jie 
Published: March 2024

BackgroundSARS-CoV-2 strains have been of great concern due to their high infectivity and antibody evasion.MethodsIn this study, data were collected on indigenous aggregated outbreaks in Nanjing from January 2020 to December 2022, caused by five strains including the original strain, the Delta variant, and the Omicron variant (BA.2, BA.5.2, and BF.7). The basic epidemiological characteristics of infected individuals were described and then parametric analysis of transmission dynamics was performed, including the calculation of incubation period, serial interval (SI), the basic reproductive number (R0), and the household secondary attack rate (HSAR). Finally, we compared the trends of transmission dynamic parameters of different strains.ResultsThe incubation period for the original strain, the Delta variant, Omicron BA.2, Omicron BA.5.2, and Omicron BF.7 were 6 d (95% CI: 3.5–7.5 d), 5 d (95% CI: 4.0–6.0 d), 3 d (95% CI: 3.0–4.0 d), 3 d (95% CI: 3.0–3.0 d), and 2 d (95% CI: 2.0–3.0 d), respectively; Also, the SI of the five strains were 5.69 d, 4.79 d, 2.7 d, 2.12 d, and 2.43 d, respectively. Notably, the incubation period and SI of the five had both a progressive shortening trend (p &lt; 0.001); Moreover, R0 of the five were 2.39 (95% CI: 1.30–4.29), 3.73 (95% CI: 2.66–5.15), 5.28 (95% CI: 3.52–8.10), 5.54 (95% CI: 2.69–11.17), 7.39 (95% CI: 2.97–18.76), with an increasing trend gradually (p &lt; 0.01); HSAR of the five were 25.5% (95% CI: 20.1–31.7%), 27.4% (95% CI: 22.0–33.4%), 42.9% (95% CI: 34.3–51.8%), 53.1% (95% CI: 45.0–60.9%), 41.4% (95% CI, 25.5–59.3%), also with an increasing trend (p &lt; 0.001).ConclusionCompared to the original strain, the incubation period and SI decreased while R0 and HSAR increased, suggesting that transmission in the population was faster and the scope of the population was wider. Overall, it’s crucial to keep implementing comprehensive measures like monitoring and alert systems, herd immunization plans, and outbreak control.