bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dermatomyositis and female malignancy
Authors: Callen Jeffrey P. 
Published: February 2007

AbstractSix female patients, all with dermatomyositis (DM) and malignancy, have been evaluated and followed over a period of up to 6 years. Five patients had malignancy prior to the diagnosis of DM. Two of these five patients had uterine endometrial adenocarcinoma and another two patients had cervical carcinomas (one each adenocarcinoma and squamous cell carcinoma), and one had adenocarcinoma of the breast. in these five patients there was no evidence of malignancy at the time of diagnosis of DM. One of these five patients had an additional primary malignancy (adenocarcinoma of the breast) which complicated her course. An ovarian adenocarcinoma was present in the sixth patient. The ovarian carcinoma was discovered because of progressive cutaneous disease, and resection and chemotherapy led to a partial control of the DM. The patient with adenocarcinoma of the cervix developed metastases which were discovered when the DM became resistant to therapy. Although DM can parallel the course of a malignant disease, this was not generally the case in this group of patients.
Retroperitoneal malignant fibrous histiocytoma presenting with inferior vena caval obstruction
Authors: Sarma Deba P. , Weilbaecher Thomas G. 
Published: February 2007

AbstractA 54‐year‐old‐man presented with inferior vena caval obstruction. At autopsy, a retroperitoneal malignant fibrous histiocytoma was noted to have invaded the inferior vena cava. Such a clinical presentation is quite unusual for a retroperitoneal sarcoma.
Prognostic value of preoperative serum cea level compared to clinical staging IV. Histological grading and tumor type in colorectal and gastric cancer
Authors: Bogenschütz O. , Brümmendorf T. , Staab H. J. , Anderer F. A. , Kieninger G. 
Published: February 2007

AbstractIn a clinical investigation of observed postoperative survival, 410 patients with colorectal cancer and 269 patients with stomach cancer have been registered for primary surgical treatment connected with a long‐term follow up. Histologic grading and tumor typing were examined as potential prognostic factors and compared with the prognostic information covered by operability, tumor extension, and the preoperative CEA level. Statistical treatment of the data revealed no prognostic significance of the tumor types adenocarcinoma, mucinous, and anaplastic tumours in gastric cancer. Histologic grading specified ranges associated with significant differences in survival of gastric and colorectal cancer patients. However, histologic grading did not provide prognostic information in addition to operability and tumor extension. However, histologic grading gave additional prognostic information to preoperative CEA levels in the range of 0‐5 μg CEA/1 serum but not in the range > 5 μg CEA/1. The results indicate that the prognostic information of preoperative serum CEA level is not directly linked to the histologic grade of a tumor.
Spontaneous breast infarction associated with pregnancy presenting as a palpable mass
Authors: Jimenez Jorge F. , Ryals Rickey O. , Cohen Cynthia 
Published: February 2007

AbstractSpontaneous infarction of physiologically hyperplastic breast tissue or of an adenoma‐fibroadenoma presenting as breast mass during pregnancy or in the early postpartum period is a recognized but rare clinical pathologic entity. Only 24 such cases have been reported in the English language literature to our knowledge. We report four additional cases of breast infarction associated with pregnancy, review the literature, and discuss possible etiologies and pathogenesis of this uncommon event.
Spindle cell carcinoma of the breast: Case report and review
Authors: Sheridan Robert , Robbins Sandy , D'Avis Juan C. , Collins George J. 
Published: February 2007

AbstractSpindle cell carcinoma is a distinct, but unusual, variant of squamous cell carcinoma. It is seen most frequently in the upper aerodigestive tract and esophagus. The natural history seems to be similar to that of the more typical squamous cell carcinoma.A case of spindle cell carcinoma arising from the ductal epithelium of the breast is reported. The light and electron microscopic histology is described. A review of the literature suggests that this rare neoplasm should be managed in a fashion similar to that for more common types of epithelial breast duct malignancies.
Primary leiomyosarcoma of the right common iliac artery — A rare finding and a cause of occlusive vascular disorder
Authors: Gutman Haim , Haddad Menashe , Zelikovski Avigdor , Mor Celia , Reiss Raphael 
Published: February 2007

AbstractA case of primary intraluminal leiomyosarcoma of the right common iliac artery that presented itself by intermittent claudication is described. The diagnosis was established only postoperatively, based on examination of the endarterectomy specimen. No other primary tumor was found in the postoperative investigation and the patient received no further treatment. A review of the literature attests to the rarity of the diagnosis and the uncertainty regarding the mode of treatment.
Primary malignant tracheal neoplasms: Case reports and literature radiotherapy review
Authors: Ampil Federico L. 
Published: February 2007

AbstractIn contrast to laryngeal or bronchial carcinomas, primary malignant neoplasm of the trachea is rarely encountered. Case reports are presented to emphasize the difficulty in establishing the diagnosis. Disease clinical manifestations, histopathology, and natural history are described. A literature review summary of radiotherapy results on reported large series of patients is shown.
Radiation‐associated thyrotoxicosis
Authors: Katayama Shigehiro , Shimaoka Katsutaro , Osman Gamal 
Published: February 2007

AbstractWe studied 154 consecutive patients with a diagnosis of thyrotoxicosis seen at Roswell Park Memorial Institute from 1963 to 1982. The retrospective review of the clinical materials revealed that 23 (15%) had a previous history of therapeutic radiation for various diseases. The radiation dose ranged from several to 3600 rads to the thyroid with a mean latency of 14.2 ± 3.0 years. In 11 out of 16 patients who were tested for antithyroglobulin and antimicrosomal showed positive liters of either or both antibodies (69%). In a small number of patients, thyroid stimulating immunoglobulins were studied; long‐acting thyroid stimulators (LATS) were positive in one of six tested and thyrotrophin binding inhibitory immunoglobulins (TBII) in five of eight. The radiation‐associated thyroidal dysfunction appears to be associated with the organ‐specific autoimmune processes and could manifest as either hypo‐ or hyperfunction of the gland.
An unusual presentation of colon cancer
Authors: Morton Blaine A. , Scholes John , Kral John G. 
Published: February 2007

AbstractA rare case of asymptomatic cancer of the ascending colon presenting as a subcutaneous groin mass is reported. At the time of right hemicolectomy with resection of the groin mass there was no sign of incontinuity spread or lymph blockage. Sequential determination of carcinoembryonic antigen levels (CEA) in serum reflected the reduction in tumor mass after surgery as well as subsequent recurrences of disease in the groin and in the lung after 2 years. Immunoperoxidase staining of the primary tumor and the metastases showed strong positivity for CEA confirming the origin of the serum CEA. There have been no signs of liver involvement. The route of spread of this unusual metastasis is not known.
Primary lymphoma of the central nervous system: A clinicopathologic analysis of 26 cases
Authors: Vakili Saeed T. , Muller Jans , Shidnia Homayoon , Campbell Robert L. 
Published: February 2007

AbstractWe analyzed 26 cases of primary lymphoma of the central nervous system. There were 14 males and 12 females ranging in age from 5‐76 years (median age 51 years, mean age 50.2 years). None had received organ transplantation or immunosuppressive therapy. The most common presenting symptoms were headache, mental changes, nausea, vomiting, and convulsions. The main neurological findings were hemiparesis, papilledema, visual field defects, and cranial nerve palsies. The most common finding in the cerebrospinal fluid (CSF) was high protein content; CSF cytology was positive in only one case. Computerized tomography was done in 14 cases; all showed a contrast‐enhancing lesion. Angiography generally revealed an avascular mass. The most common location above tentorium was the frontal lobe; in four cases the tumor was infratentorial (cerebellum, 3 cases). In five cases there was diffuse involvement of the brain; all had severe dementia and diagnosis was not made until the autopsy. Histologically, the most common type was diffuse histiocytic or immunoblastic lymphoma according to Rappaport and the Working Formulation classification respectively. Radiation therapy alone in five patients gave a median survival of 17 months. Five patients received radiation and chemotherapy, and median survival was 16 months. Two patients developed ocular lymphoma 8 and 36 months later that was treated by radiation.
Aminocaproic acid (AMICAR) in advanced colorectal carcinoma
Authors: Petrelli Nicholas J. , Markus Cabor , Herrera Lemuel , Corasanti James , Mittelman Arnold 
Published: February 2007

AbstractWe treated 20 patients with measurable histologically confirmed colorectal adenocarcinoma with aminocaproic acid (AMICAR). There were 11 males and 9 females with a median age of 63 years. All 20 patients had received prior chemotherapy. The majority of monitoring lesions were distributed between lung and liver. We evaluated 12 patients in this series for response. Three patients had stable disease and nine patients had progressive disease. All patients were evaluable for toxic effects, the most common being nausea and vomiting. AMICAR given orally at 210 mg/kg of actual body weight/day is not an effective single agent in the treatment of metastatic colorectal carcinoma. In view of previously published animal data the role of AMICAR in the adjuvant setting for colorectal carcinoma still needs to be determined.
Focal nodular hyperplasia and hepatic adenoma: A review of eight cases in the pediatric age group
Authors: Lack Ernest E. , Ornvold Kim 
Published: February 2007

AbstractA review of all primary hepatic tumors seen at Children's Hospital, Boston over a 57‐year period disclosed six cases of focal nodular hyperplasia (FNH) and two hepatic adenomas (HA). The children with FNH (four females, two males) ranged in age from 6 months to 15 years (average age: 7 years). Three patients had “hepatomegaly” noted on physical examination 2 months to 2 or more years prior to diagnosis. The average diameter of FNH was 7.3 cm (range 2.5‐10 cm). The lesion was confined to the right lobe in four cases and showed bilobar involvement in two. The HA's were diagnosed in a newborn male and a 2‐year‐old girl, both of whom were symptomatic because of large tumor size (10 cm each). There was no maternal history of exposure to exogenous steroids during pregnancy. Three children with FNH underwent hepatic lobectomy and were alive and well 4 to 17 years later. One child who died of acute leukemia had an incidental FNH discovered at autopsy. Two patients were treated conservatively with biopsy only and were alive and symptom‐free 13 and 15 years later. Both children with HA underwent hepatic lobectomy. One died postoperatively because of intra‐abdominal hemorrhage and the other was alive and well 101A years later. Complete surgical resection is recommended for most children with HA when technically feasible because of 1) the lingering suspicion of possible (albeit remote) malignant transformation and 2) diagnostic difficulties in distnguishing HA from a well‐differentiated hepatocellular carcinoma.
Adenosquamous carcinoma of the common bile duct: A case report
Authors: Lantsberg Leonid , Khodadadi Jalinus , Goldstein Jed 
Published: February 2007

AbstractReported here is a case of primary adenosquamous carcinoma of the common bile duct. This unusual variant of the ordinary adenocarcinoma has not, to the best of our knowledge, been previously reported as occurring in the extrahepatic bile ducts. A tumor of notorious prognostic significance, it represents an exceedingly rare and peculiar biological phenomenon of malignant metaplastic change.
Clinical studies on serum immunosuppressive acidic protein (IAP) and ferritin in gastric cancer patients: With special reference to preoperative value and influence of surgical stress
Authors: Saji Shigetoyo , Yokoyama Yukio , Niwa Hikoo , Takao Hiroshi , Kida Hisashi , Kawata Ryo , Tanemura Hiromi , Sakata Kazuki 
Published: February 2007

AbstractSerum IAP and ferritin values were measured preoperatively in 83 resectable gastric cancer patients. IAP was significantly higher in them than in normal subjects, and increased gradually with progression of cancer, and the values at stages III and IV were significantly higher than that at stage I. It was significantly higher in the cases of n(+) than in those of n(‐), and in the cases of noncurative resection than in those of curative resection. Ferritin was significantly higher in them than in normal subjects and mammary cancer patients, and in males than in females, and the values at stages I and IV were significantly higher than that at stage III.OK‐432 was serially administered pre‐ and postoperatively in 83 cases and only postoperatively in 33 cases. IAP increased markedly at 1 week postoperatively and was reduced gradually at 2 and 4 weeks. Ferritin increased markedly at 1 week after operation and reached the maximum value at 2 weeks and was reduced toward the value of 1 week at 4 weeks. However, these changes showed no significant difference between the both groups.
Giant basal cell carcinoma with metastases and myelophthisic anemia
Authors: Schwartz Robert A. , De Jacer Robert L. , Janniger Camila Krysicka , Lambert W. Clark 
Published: February 2007

AbstractWe report a 59‐year‐old, dark‐complexioned black man with a giant basal cell carcinoma infiltrating virtually the entire scalp. Widespread metastatic bone marrow involvement produced a myelophthisic anemia. Basal cell carcinoma is rare in blacks, is rarely this large, and very rarely produces myelophthisic anemia from bone marrow metastases.
An unusual site of presentation for Hodgkin's disease in the middle ear
Authors: Zahra Mohammed , Tewfik Ferial 
Published: February 2007

AbstractWe are presenting a case history of a patient with advanced Hodgkin's disease, who had secondary involvement of his middle ear. To our knowledge this is the first case report of such clinical presentation where radiation therapy was of good help for bringing about symptomatic relief. Possible routes of spread are discussed and the literature is reviewed.
Primary gastrointestinal lymphoma incidence, clinical presentation, and surgical approach
Authors: Bäck Hans , Gustavsson Bengt , Ridell Börje , Rödjer STIG , Westin Jan 
Published: February 2007

AbstractDuring a 5‐year period, 15 cases of primary gastrointestinal lymphoma, corresponding to 14% of the non‐Hodgkin's lymphomas, were diagnosed in a population of 200,000. Most patients had a short duration of symptoms—less than 3 months—and a clinical picture dominated by abdominal pain. All patients were laparotomized and six patients presented with an acute abdomen and were subjected to emergency operations. In seven cases, gastrointestinal malignancy was not suspected preoperatively. The patients were treated with a combination of surgery, cytostatic therapy, and/or radiotherapy. Cases with localized disease had a favorable prognosis, seven of nine patients being alive 31 to 70 months after diagnosis. A statistically significant difference in median survival was also noted between patients with lymphomas of low‐grade and high‐grade malignancy (70+ vs. 10.5 months).
Gallbladder adenocarcinoma: Prognostic significance of tumor acid mucopolysaccharide content
Authors: Johnson Lewis A. , Lavin Philip T. , Dayal Yogeshwar Y. , Geller Stephen A. , Doos Wilhelm G. , Cooper Harry S. , Gerber John E. , Masse Serge T. , Weiland Louis H. , Moertel Charles G. , Engstrom Paul F. 
Published: February 2007

AbstractThe gall bladder mucosa is composed of neutral mucopolysaccharide and protein radical containing secretory cells, protein radical containing migratory cells, and neutral and acid mucopolysaccharides plus sialic acid containing goblet cells. The prognostic significance of histologic or histochemical parameters in gall bladder adenocarcinoma (GBA) are unknown. To determine if histochemical acid mucopolysaccharide content in GBA has prognostic value, GBA histologic sections from 26 advanced stage disease patients participating in Eastern Cooperative Oncology Group (ECOG) treatment study EST‐2273 were stained with alcian blue at pH. 1.0, assessed by a pathology panel for either high (> 50%) or low (< 50%) acid mucopolysaccharide content, and correlated with patient survival. Initial panel unanimous concurrence rate on acid mucopolysaccharide content was 88.9%. Median survival times from the start of chemotherapy to date of death for high acid mucopolysaccharide content GBA was 14 weeks versus five weeks for the low content GBA (P < 0.0001). The results indicate that high acid mucopolysaccharide content in GBA significantly improves prognosis. ECOG recommends stratification by acid mucopolysaccharide content in future GBA treatment investigations.
Kaposi's sarcoma: Report of five cases treated with radiotherapy
Authors: Ampil Federico L 
Published: February 2007

AbstractFive patients with Kaposi's sarcoma seen and treated at the Louisiana State University Medical Center in Shreveport from 1970 to 1984 are presented. A complete response was observed in two patients who received extended‐field irradiation. Results obtained with external beam radiotherapy for this disease from other reported patients series are summarized.
Gallbladder adenocarcinoma: The prognostic significance of histologic grade
Authors: Johnson Lewis A. , Lavin Philip T. , Dayal Yogeshwar Y. , Geller Stephen A. , Doos Wilhelm G. , Cooper Harry S. , Gerber John E. , Masse Serge R. , Weiland Louis H. , Moertel Charles G. , Engstrom Paul F. 
Published: February 2007

AbstractGallbladder adenocarcinoma (GBA) postresection 5‐year survival rates are less than 5%, but when histologically confined to the mucosa or submucosa, survival rates of 64% (5 years) and 44% (10 years) have been reported. Whether any other histologic features of GBA have prognostic significance is unknown. This investigation was conducted to determine if GBA histologic grade correlates with survival. Thirty patients with advanced stage GBA participating in Eastern Cooperative Oncology Group (ECOG) treatment protocol EST‐2273 served as the study material. Using glandular tumor grade criteria recommended by others, a panel of 7 ECOG pathologists categorized the GBA as either predominantly low or high histologic grade. Each patient's GBA histologic section measured no less than 1.0 × 1.0 cm. Predominant grade was defined as being that grade present in > 75% of the histologic section. Patient survival times by grade were calculated from date of initiation of chemotherapy until date of death. The 13‐week low grade GBA patient survival was significantly longer than the 7‐week high grade GBA patient survival (p < 0.01). Stratification of patients by either high or low predominant histologic grade is recommended in future GBA treatment studies.
Radiation after pelvic lymphadenectomy: Effect on morbidity
Authors: Babaian R. Joseph , Aguilar Orlando F. 
Published: February 2007

AbstractThe role of a staging pelvic lymph node dissection has been questioned because of its associated morbidity, especially when followed by definitive radiation therapy. Forty‐nine patients with clinically localized adenocarcinoma of the prostate underwent a staging pelvic lymphadenectomy. Clinically suspected lymph nodes were submitted for frozen section analysis. A unilateral dissection was performed on 7 patients (14%), none of whom developed intraoperative or postoperative complications. The remaining 42 patients underwent bilateral pelvic lymphadenectomy, after which 26 were treated with definitive radiation therapy using the four‐field box technique, and 16 received other forms of therapy (delayed androgen deprivation or hormonal manipulation). The complication rate of 19% was identical for both groups of patients. Complications consisted of 3 seromas, 1 atelectasis, 1 prolonged ileus, 1 wound infection, and 2 transient penile or scrotal edemas. Radiation therapy, therefore, did not increase postoperative morbidity.
Suppressor T cell activity in lymphoid interstitial pneumonia
Authors: Majeski James A. , Stinnett J. Dwight , Cameron Deborah J. 
Published: February 2007

AbstractA case of lymphoid interstitial pneumonia was investigated for immunological abnormalities. Suppressor T cells were found. The abnormality in the lymphoid system could be corrected in vitro with levamisole. The patient thereafter developed histiocytic lymphoma and soon died without any response to chemotherapy.
Metastatic melanoma of the gallbladder: A case report and review of the literature
Authors: Murphy Maurice N. , Lorimer Susan M. , Glennon Peter E. 
Published: February 2007

AbstractA single case of symptomatic metastatic melanoma to the gallbladder, with roentogenographic findings of gallbladder disease, is presented. Review of the 12 previously reported cases of symptomatic metastatic biliary melanoma and of those reports of “primary” melanoma of the gallbladder reveals marked similarity between the two groups, with regard to relative size, pathologic description, number, and location of lesions. This, together with the finding of “junctional activity” in our case, leads us to believe that most if not all melanomas present in the gallbladder are metastatic deposits from a known, undetected, or regressed primary locus elsewhere. Surgical removal, even in the presence of disseminated disease, is a worthwhile palliative procedure.
Comparison of primary and secondary treatment in squamous oral cancer
Authors: Moore Condict , Flynn Michael B. , Knox Robert , Newman Donald A. , Greenberg Richard A. 
Published: February 2007

AbstractA popular rule of thumb has often prevailed in treating oral cancer: Try one modality first; if it fails, try the other—the chance for cure will still be good. To study this dogma, a group of 160 consecutive patients with oral cavity squamous carcinoma were reviewed. A hypothesis was formed: secondary treatment for recurrent cancer, whether surgery after radiation failure or vice versa, would salvage essentially as many patients as primary treatment, say within 15%. Results show a large difference in success rates between first and second treatments when all stages are considered together, a difference well over 15 percentage points. Regarding each stage separately, the largest difference occurs in stage II (28 percentage points); other stages exceed 15 point differences. No significant differences in successful salvage occur between “home” failures and “elsewhere” failures. Local recurrence was a major cause of failure in both groups (55%). We conclude that recurrence of oral squamous cancer after first treatment markedly reduces patients' chance for cure.