bluuebunny/crossref_metadata_2025_split huggingface dataset:
Examining the impact of COVID-19 disruptions on population-based breast cancer screening in Ireland
Authors: O’Driscoll Jessica , Mooney Therese , Kearney Paul , Williams Yvonne , Lynch Suzanne , Connors Alissa , Larke Aideen , McNally Sorcha , O’Doherty Ann , Murphy Laura , Bennett Kathleen E. , Fitzpatrick Patricia , Mullooly Maeve , Flanagan Fidelma 
Published: March 2024

Objective Many population-based breast screening programmes temporarily suspended routine screening following the COVID-19 pandemic onset. This study aimed to describe screening mammography utilisation and the pattern of screen-detected breast cancer diagnoses following COVID-19-related screening disruptions in Ireland. Methods Using anonymous aggregate data from women invited for routine screening, three time periods were examined: (1) January–December 2019, (2) January–December 2020, and (3) January–December 2021. Descriptive statistics were conducted and comparisons between groups were performed using chi-square tests. Results In 2020, screening mammography capacity fell by 67.1% compared to 2019; recovering to 75% of mammograms performed in 2019, during 2021. Compared to 2019, for screen-detected invasive breast cancers, a reduction in Grade 1 (14.2% vs. 17.2%) and Grade 2 tumours (53.4% vs. 58.0%) and an increase in Grade 3 tumours (32.4% vs. 24.8%) was observed in 2020 ( p = 0.03); whereas an increase in Grade 2 tumours (63.3% vs. 58.0%) and a reduction in Grade 3 tumours (19.6% vs. 24.8%) was found in 2021 ( p = 0.02). No changes in oestrogen receptor-positive or nodal-positive diagnoses were observed; however the proportion of oestrogen/progesterone receptor-positive breast cancers significantly increased in 2020 (76.2%; p < 0.01) and 2021 (78.7%; p < 0.001) compared to 2019 (67.8%). Conclusion These findings demonstrate signs of a grade change for screen-detected invasive breast cancers early in the pandemic, with recovery evident in 2021, and without an increase in nodal positivity. Future studies are needed to determine the COVID-19 impact on long-term breast cancer outcomes including mortality.
Assessing Appearance, Speech, and Hearing (dis)Satisfaction in Individuals with Cleft Lip and/or Palate: A Contribution to General Population Norms
Authors: Stock Nicola M. , Costa Bruna , White Paul , Eve Lauren , Bates Amanda J. 
Published: March 2024

Background Individuals with cleft lip and/or palate (CL/P) may grow up with a visible facial difference, alongside speech and/or hearing challenges. Self-perceptions are stronger predictors of psychosocial adjustment than objective assessments, highlighting the importance of patient-reported outcome measures. Previously titled the Satisfaction with Appearance (SwA) questionnaire, the Cleft Hearing, Appearance and Speech Questionnaire (CHASQ) has been used in several countries to assess patient satisfaction, guide clinical decision-making, and conduct craniofacial research, but has lacked general population norms from which to draw comparisons. The aim of this study was to contribute to the development of norms by utilising existing data collected in the United Kingdom (UK) in 2004 using the original SwA. Methods SwA data collected from school pupils ( n = 761) aged 10–16 years were analysed across age and gender. Results Hair, Eyes and Ears received the highest ratings, while Teeth received the lowest ratings. Those who were younger, and those who were male, generally rated their appearance more favourably. Thresholds are proposed to identify young people in need of clinical monitoring (10%) and intervention (5%). Discussion This study supports the potential of the CHASQ as a clinically useful outcome measure and research tool with the ability to identify appearance concerns in relation to specific facial features, as well as overall appearance satisfaction in young people with and without CL/P. Further validation of its use in the CL/P population and other patient groups, as well as countries outside the UK would add additional weight to the CHASQ's utility.
Risk of multiple sclerosis in individuals with infectious mononucleosis: a national population-based cohort study using hospital records in England, 2003–2023
Authors: Goldacre Raphael 
Published: March 2024

Background: Epstein–Barr virus (EBV) is thought to be a necessary causative agent in the development of multiple sclerosis (MS). Infectious mononucleosis (IM), which occurs up to 70% of adolescents and young adults with primary EBV infection, appears to be a further risk factor but few studies have been highly powered enough to explore this association by time since IM diagnosis. Objective: The objective was to quantify the risk of MS in individuals with IM compared with the general population, with particular focus on time since IM diagnosis. Methods: In this retrospective cohort study using English national Hospital Episode Statistics from 2003 to 2023, patients with a hospital diagnosis of IM were compared with the general population for MS incidence. Results: MS incidence in patients with IM was nearly three times higher than the general population after multivariable adjustment (adjusted hazard ratio = 2.8, 95% confidence interval (CI = 2.3–3.4), driven by strong associations at long time intervals (>5 years) between IM diagnosis and subsequent MS diagnosis. Conclusion: While EBV infection may be a prerequisite for MS, the disease process of IM (i.e. the body’s defective immune response to primary EBV infection) seems to be, in addition, implicated over the long term.
No evidence for association between rs10191329 severity locus and longitudinal disease severity in 1813 relapse-onset multiple sclerosis patients from the MSBase registry
Authors: Campagna Maria Pia , Havrdova Eva Kubala , Horakova Dana , Izquierdo Guillermo , Matesanz Fuencisla , Eichau Sara , Lechner-Scott Jeannette , Taylor Bruce V , García-Sanchéz Maria-Isabel , Alcina Antonio , van der Walt Anneke , Butzkueven Helmut , Jokubaitis Vilija G 
Published: March 2024

Background: The International Multiple Sclerosis Genetics Consortium and MultipleMS Consortium recently reported a genetic variant associated with multiple sclerosis (MS) severity. However, it remains unclear if these variants remain associated with more robust, longitudinal measures of disease severity. Methods: We examined the top variant, rs10191329, from Harroud et al.’s study in 1813 relapse-onset MS patients from the MSBase Registry to assess association with longitudinal disease severity. Results: Our analysis revealed no significant association between rs10191329 genotype and longitudinal binary disease severity ( p > 0.05). Conclusion: These findings highlight the complexity of genetic factors mediating long-term MS outcomes and the need for further research.
“Puro English and a little bit of Spanish”: Bi/multilingual kindergarteners’ language ideologies in a dual language bilingual class during the COVID-19 pandemic
Authors: Buckband Cory , Kaveh Yalda M. , Ozbek-Damar Seda , Yuhas Brandon 
Published: March 2024

Aims: The goal of the study is to examine bi/multilingual children’s language beliefs and their contributions to school and family language policies in a two-way dual language bilingual education (DLBE) program in the United States while participating in online schooling from home. Methodology: We report from a larger critical ethnographic study with a Title I K-8 school in Arizona. The data for this study are based on ethnographic fieldwork during the 2020–2021 academic year with a DLBE kindergarten cohort. Data and analysis: We conducted semi-weekly class observations and individual semi-structured interviews with 12 bi/multilingual kindergarten children. Data analysis entailed a multi-step thematic analysis through several rounds of focused coding. Findings: Our findings show that the children were deeply aware of the languages they spoke, their proficiency in each, how they chose to express those proficiencies, and the way they identified with each language. We identify ways that children agentively used language to transcend separative language policies by using language fluidly. Originality: The study contributes to the literature on young children’s language policymaking and their reproductive and resistive forms of agency. Our child participants were 5 and 6 years old, an underrepresented age in research that connects school and family language policies. Furthermore, this group’s linguistic, racial-ethnic, and cultural diversity allows for a deeper glimpse into how bi/multilingual children develop complex identities. Implications: The study has implications for the importance of pedagogical and linguistic flexibility with young children in DLBE programs. The study shows the importance of how young bi/multilingual children respond to the processes of implementing a program by highlighting the role and position of each language in their home and school environments.
Shaping ideologies at the micro level: Stylization in EMI
Authors: Mendoza Anna 
Published: March 2024

Purpose: Research on bi/multilingual oral interactions in English-medium instruction (EMI) is often concerned with how languages the teacher and/or students speak can be used for pedagogical scaffolding processes. In contrast, this paper aims to investigate how stylization of languages, including those that teacher and students only speak minimally, can likewise be harnessed for important pedagogical and interpersonal purposes. Methodology: I conduct an interactional sociolinguistic analysis of transcripts from an EMI teaching simulation in a Master’s in Education course at a university in Hong Kong. Data and analysis: As a cross-border teacher from Cantonese-speaking Guangdong and a local teacher of Indian heritage engaged in these language stylization processes, they show that teachers can effectively use bi/multilingual stylization in EMI with attention to student uptake and response. Findings/Conclusions: While pedagogical scaffolding is important in EMI, these processes can put more and less societally dominant languages in a diglossic, unequal relationship. In contrast, stylization can reconfigure classroom language norms and hierarchies, attach positive meanings to unratified codes, and allow teachers to share linguistic authority with students. Originality: Little research to date has studied stylization as a pedagogical resource in EMI, focusing instead on the use of languages teachers/students already know for scaffolding. Significance/Implications: Teacher professional development should address the topic of how to use language stylization in EMI, especially since these interactional strategies do not require teachers to dramatically reconfigure curriculum or instruction, yet have pedagogical and interpersonal benefits. Limitations: Future research should aim to study stylization in EMI in an authentic classroom setting.
Physical activity coaching in patients with interstitial lung diseases: A randomized controlled trial
Authors: Breuls Sofie , Zlamalova Tamara , Raisova Katerina , Blondeel Astrid , Wuyts Marieke , Dvoracek Martin , Zurkova Monika , Yserbyt Jonas , Janssens Wim , Wuyts Wim , Troosters Thierry , Demeyer Heleen 
Published: March 2024

Objectives Physical activity is reduced in patients with interstitial lung disease (ILD) and physical inactivity is related to poor health outcomes. We investigated the effect of a telecoaching intervention to improve physical activity in patients with ILD. Methods Eighty patients with ILD were randomized into the intervention or control group. Patients in the intervention group received a 12-week telecoaching program including a step counter, a patient-tailored smartphone application, and coaching calls. Patients in the control group received usual care. Physical activity (primary outcome), physical fitness and quality of life were measured at baseline and 12 weeks later with an accelerometer, 6-min walking test and quadriceps muscle force and the King’s Brief Interstitial Lung Disease questionnaire (K-BILD). Results Participation in telecoaching did not improve physical activity: between-group differences for step count: 386 ± 590 steps/day, p = .52; sedentary time: 4 ± 18 min/day, p = .81; movement intensity: 0.04 ± 0.05 m/s2, p = .45). Between-group differences for the 6-min walking test, quadriceps muscle force and K-BILD were 14 ± 10 m, p = .16; 2 ± 3% predicted, p = .61; 0.8 ± 1.7 points, p = .62 respectively. Conclusions Twelve weeks of telecoaching did not improve physical activity, physical fitness or quality of life in patients with ILD. Future physical or behavioural interventions are needed for these patients to improve physical activity.
Translating novel collective behaviour measures to concepts and principles of play as understood by football coaches
Authors: Corsie Martin , Malone Michael , Swinton Paul A 
Published: March 2024

Background A range of innovative performance analysis metrics have been applied in recent years to investigate aspects of football using tempo-spatial and network analyses. These approaches have gained traction within some professional teams to quantify and assess features of collective behaviour. However, metrics employed are rarely created from, or clearly link to, domain expertise and as a result coaches may be hesitant of their value. Therefore, the aim of this study was to identify coach perceptions of spatial temporal and network metrics and identify the feasibility of an iterative and collaborative process to developing metrics. Methods Two rounds of semi-structured interviews were conducted with three Scottish youth international UEFA Pro License coaches (age: 47.0 ± 2.7 years) with a focus on aligning metrics with concepts and principles of play. An iterative approach was used centring around spatial-temporal and network metrics and their adaptation. Reflexive thematic analyses were conducted with final metrics categorized as resonant (accurately describing concept or principles of play), relevant (appropriate but with limitations that need improvement), or hesitant (skeptical of usefulness). Results Across the ten recognized principles of play, nine metrics were identified and adapted to varying degrees. Resonant metrics included: network intensity (mobility), distance between defenders (discipline), triangles (support), team length and distance between deepest defender and goal line (depth). Conclusion Coaches recognize principles of play within complex collective behaviour metrics and should be encouraged to collaborate with analysts to develop support systems that may prove to be more valuable and usable.
What are the available online resources targeting psychosocial burden among stroke survivors and their informal caregivers: A scoping review
Authors: Delvallée Marion , Garreau Romain , Termoz Anne , Ploteau Pierre-Marie , Derex Laurent , Schott Anne-Marie , Haesebaert Julie 
Published: March 2024

BackgroundAfter discharge home, stroke survivors and their informal caregivers face a significant lack of support and information which accentuates their psychosocial burden. Online resources might provide this support and address psychosocial needs, but existing online stroke programmes mainly target functional rehabilitation. We aimed to map the existing literature on online resources that have been evaluated in stroke rehabilitation and aimed at reducing psychosocial impact in stroke survivors and informal caregivers.MethodsMEDLINE was searched (2010–2024) to identify studies investigating online resources targeting psychosocial health. Studies were selected and extracted independently by two reviewers. We described the content, use, and psychosocial impact of these interventions using a narrative approach.ResultsEleven studies were included in the review, reporting 10 online resources (two studies relating to the same resource). Online resources were heterogeneous: eight information/resources websites, one mobile app, and one forum. Five online resources were dedicated to stroke survivors, four to stroke survivors and their informal caregivers, and one to informal caregivers. Two randomized controlled trials reported a significant decrease in depressive symptoms associated with the use of online resources. Stroke survivors and informal caregivers find online resources useful and acceptable to address their psychosocial needs.ConclusionsFew online stroke resources have been designed and evaluated to support post-stroke psychosocial rehabilitation. Further larger-scale research needs to study the impact of these interventions on psychosocial recovery over time.
Predictive Models for Canadian Healthcare Workers Mental Health During COVID-19
Authors: Kumari Bhawna , Goyal Nidhi , El Morr Christo 
Published: March 2024

Purpose: COVID-19 impact on the population’s mental health has been reported worldwide. Predicting healthcare workers’ mental health and life stress is needed to proactively plan for future emergencies. Design: Statistics Canada has surveyed Canadian healthcare workers and those working in healthcare settings to gauge their perceived mental health and perceived life stress. Setting: A cross-sectional survey of healthcare workers in Canada. Subjects: A sample of 18,139 healthcare workers respondents. Analysis: Eight algorithms, including Logistic Regression, Random Forest (RF), Naive Bayes (NB), K Nearest Neighbours (KNN), Adaptive boost (AdaBoost), Multi-layer perceptron (MLP), XGBoost, and LightBoost. AUC scores, accuracy and precision were measured for all models. Results: XGBoost provided the highest performing model AUC score (AUC = 82.07%) for predicting perceived mental health, and Random Forest performed the best for predicting perceived life stress (AUC = 77.74%). Perceived health, age group of participants, and perceived mental health compared to before the pandemic were found to be the most important 3 features to predict perceived mental health and perceived stress. Perceived mental health compared to before the pandemic was the most important predictor for perceived life stress. Conclusion: Our models are highly predictive of healthcare workers’ perceived mental health and life stress. Implementing scalable, non-expensive virtual mental health solutions to address mental health challenges in the workplace could mitigate the impact of workplace conditions on healthcare workers’ mental health.
Comparative Evaluation of Penetrability of Various Bioceramic Sealers into the Tubules of Radicular Dentin
Authors: Choudhary Deebah , Gupta Ana , Bharti Nidhi 
Published: March 2024

Aim: This study aimed to evaluate the penetration depth and persistence of sealer residues in obturated canals with three different bioceramic sealers using confocal microscopy. Materials and Methods: In total, 60 single-rooted human premolars were selected and decoronated to maintain the working length of 14 mm. The samples were biomechanically prepared and obturated with Protaper Universal GP coated with three different bioceramic sealers, that is, CeraSeal RC, Bio-C and MTA Fillapex. The specimens were divided into three groups ( n = 20) depending on the sealer used. Rhodamine B fluorescent dye was added to the sealers before using them for obturation. The obturated samples were sealed and placed in 100% humidity at 37oC for 7 days. Gutta-percha was removed from all the samples using retreatment files. Each sample was horizontally sectioned into 2 mm thick slices at 3 mm and 5 mm from the apex, which were analysed under a confocal scanning microscope to detect the depth of penetration of sealer into the dentinal tubules. Data were analysed using one-way ANOVA and Tukey’s post hoc tests. Results: Intergroup comparison of penetration depth at 3 mm showed that the mean depth of penetration among CeraSeal samples was found to be significantly more as compared to the other two materials, while, no statistically significant difference was found among Bio-C and MTA Fillapex with the significance level established at 5% ( P < .05). Similarly, an intergroup comparison of penetration depth at 5 mm showed that the mean depth of penetration among CeraSeal samples was found to be significantly more as compared to the other two materials, while, no statistically significant difference was found among Bio-C and MTA Fillapex. CeraSeal RC sealer showed significantly higher depth of penetration than Bio-C and MTA Fillapex. Conclusion: All bioceramic sealers show a significant penetration into the dentinal tubules. However, none of the sealers was completely removed from the tubules following retreatment.
Knee Offloading by Patients During Walking and Running After Meniscectomy
Authors: Starbuck Chelsea , Walters Vanessa , Herrington Lee , Barkatali Bilal , Jones Richard 
Published: March 2024

Background: Changes in knee loading have been reported after meniscectomy. Knee loading has previously been assessed during jogging and treadmill running rather than overground running, which could give altered results. Purpose/Hypothesis: The purpose of this study was to evaluate knee function during overground running and walking after meniscectomy. It was hypothesized that the affected limb would demonstrate higher external knee adduction moment, lower knee flexion moment (KFM), and lower knee rotation moment (KRM) compared with the contralateral limb and with healthy individuals. Study Design: Controlled laboratory study. Methods: Kinematic and kinetic data were collected during running and walking in individuals after a meniscectomy and healthy individuals. Total knee joint moments (TKJM) were calculated from the sagittal, frontal, and transverse knee moments. Isometric quadriceps strength, perceived knee function, and kinesiophobia were also assessed. A mixed linear model compared differences between the affected leg, the contralateral leg, and the healthy leg. Results: Data were collected on 20 healthy individuals and 30 individuals after a meniscectomy (mean ± SD, 5.7 ± 2.9 months postsurgery), with 12, 16, and 2 individuals who had medial, lateral, and both medial and lateral meniscectomy, respectively. The affected limb demonstrated lower TKJM ( P < .001), KFM ( P = .004), and KRM ( P < .001) during late stance of walking compared with the healthy group. Lower TKJM and KFM were observed during running in the affected limb compared with the contralateral limb and healthy group. No significant differences were observed between contralateral and healthy limbs except for KRM during late stance of walking. Lower quadriceps strength was observed in the affected ( P < .001) and contralateral limbs ( P = .001) compared with the healthy group. Individuals after a meniscectomy also reported greater kinesiophobia ( P = .006) and lower perceived knee function (31.1%; P < .001) compared with the healthy group. Conclusion: After meniscectomy, individuals who sustained a traumatic meniscal injury showed lower TKJM in the affected limb compared with the contralateral limb and healthy individuals. This decrease in TKJM can be attributed to altered knee-loading strategies in the sagittal and transverse planes. Clinical Relevance: Improving movement strategies, quadriceps strength, and kinesiophobia through rehabilitation approaches will allow individuals to load their knee appropriately when returning to sport. Registration: NCT03379415 (ClinicalTrials.gov identifier).