bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating the Efficacy and Safety of Oral Cicaglocal on Wound Healing After Mohs Surgery in Patients With Skin Cancer: A Randomized, Double‐Blinded, Placebo‐Controlled Clinical Trial
Authors: Asilian Ali , Mohammadian Parisa , Mahram Hadiseh , Shahriarirad Reza , Bigham Mohammad 
Published: February 2025

ABSTRACTBackgroundMohs micrographic surgery is the gold standard treatment for skin cancers in cosmetically sensitive anatomic areas, with a cure rate close to 100%. Managing post‐Mohs surgery wounds can pose challenges, particularly in elderly patients. This study evaluates the Cicaglocal drug, a supplement with bromelain, Centella asiatica, hyaluronan, vitamins, and minerals, for enhancing wound healing post‐Mohs surgery.MethodThis double‐blinded, randomized clinical trial conducted at Al‐Zahra Hospital in 2023 involved 24 patients aged 50–80 with SCC or BCC undergoing Mohs surgery. Patients were randomized into two groups Cicaglocal and placebo. Treatments were administered postoperatively, and outcomes such as erythema reduction, early healing score (EHS), full recovery, and patient and physician satisfaction levels were evaluated 7 and 14 days after initiation. Data were collected through clinical assessments and standardized wound photographs.ResultOral Cicaglocal demonstrated significantly improved outcomes compared to their respective placebo groups in terms of erythema score, EHS, full recovery score, and patient and physician satisfaction levels.ConclusionCicaglocal can enhance wound healing and lead to improved clinical outcomes following Mohs micrographic surgery.
Perspectives of Older Adults on Self‐Care of Chronic Diseases Utilizing Online Health Resources: An Exploratory Descriptive Qualitative Study
Authors: Lim Yu Xuan , Yap Xin Yi , Domingo Raven Viel Calangian , Tan Yue Qian , Tan Poh Choo , Wu Xi Vivien 
Published: February 2025

ABSTRACTAs the aging population grows rapidly, older adults are living longer with multiple chronic diseases. Coupled with the rise of the digital era, older adults are experiencing the brunt of the global aging phenomenon. The study aims to explore the perspectives of older adults on self‐care for chronic diseases with the application of online resources. An exploratory qualitative study with focus group discussions was conducted to shed light on the insights of older adults from senior activity centers. Purposive sampling was used to include older adults with at least one chronic disease and living in the community. Twenty older adults were interviewed face‐to‐face in four focused‐group discussions, led by a semi‐structured interview guide that thematic analysis was then applied to. Four overarching themes and 14 subthemes emerged. The four major themes were (1) Barriers to a Healthier Life; (2) Proactively Acquiring Knowledge for Health Management; (3) Socially‐influenced Health Decision‐Making, and (4) Conducive Ecosystem Encourages Health‐Promoting Behaviors. Older adults often face challenges in navigating the evolving digital landscape, yet they are receptive to learning from social networks and online resources, which help them make healthier self‐care choices. Hence, a supportive environment is essential to empower older adults to effectively utilize online resources for managing their chronic diseases.
“It's Very Cisnormatively Structured”: An Interpretive Description of Undergraduate Nursing Students' Experiences of Gender Inclusive and Affirming Practices
Authors: Crawford Jess , Kramer Marnie , Ristock Janice , Schultz Annette S. H. 
Published: February 2025

ABSTRACTThis study explores the experiences of undergraduate nursing students learning about transgender and gender diverse (TGD) health. We discuss nursing education's perpetuation of discrimination and erasure of TGD people and upholding of gender norms (cisnorms) is not sufficiently preparing students to care for TGD patients. Further, this rampant cisnormativity harms TGD nursing students. This interpretive description drew on queer theory and Hafferty's three levels of curriculum and engaged 18 undergraduate nursing students in initial and 13 in follow‐up focus groups or interviews. Three key themes included (1) cisnormativity is perpetuated in nursing education through pervasive power and norms across the three levels of curriculum; (2) “The Trans Problem”: Transgender and gender diverse people are othered in nursing education; and (3) Welcoming the other: Individual educators who welcome and affirm TGD people are crucial. Critical recommendations from students to advance gender inclusive and affirming practices are provided, including normalizing gender diversity in formal nursing education, the importance of accountability and representation in schools of nursing, and the need for nursing governing bodies to disrupt cisnormativity.
The relation between clutter and visual fatigue in children with cerebral visual impairment
Authors: Van Hove C. , Damiano C. , Ben Itzhak N. 
Published: February 2025

AbstractPurposeCerebral visual impairment (CVI) is a brain‐based condition which can be exacerbated by clutter. This study aimed to explore the relation between clutter and visual fatigue in children with CVI and evaluate the effectiveness of clutter algorithm metrics in assessing visual clutter in photographs of children's play areas and the relation to visual fatigue.MethodsVisual clutter was measured using algorithmic metrics, subjective observations by a clinical researcher (who also observed visual fatigue) and a Qualtrics survey.ResultsSeventy‐two children (mean performance age = 7 years 4 months) were included. Visual fatigue was present in over 90% of children. Results revealed a relation between clutter and visual fatigue observations (rs = 0.29; p = 0.01) and between visual clutter observations from researchers and Qualtrics participants (rs = 0.32; p = 0.02). Certain metrics were correlated with visual clutter observations (rs ranging from −0.30 to 0.51, p‐values ranging from <0.001 to 0.03), but not with visual fatigue.ConclusionsChildren with CVI presented with visual fatigue, particularly in cluttered environments. Therefore, parents, caregivers, teachers and clinicians should be attentive to visual fatigue signs, as early recognition and intervention can help address the child's needs more effectively. Algorithms that effectively quantify visual clutter are valuable tools that can be integrated to enhance the assessment of clutter and its relation with visual fatigue to advance CVI research methodology. However, a clinician is required to assess visual fatigue and to obtain detailed information on environmental clutter, which algorithms alone may not fully capture. Finally, we recognise that visual fatigue and the impact of clutter should be integrated into psychoeducation and the comprehensive assessment of individuals with CVI.
The Healthcare Needs of Children With Down Syndrome in the First Year of Life: An Analysis of the EUROlinkCAT Data Linkage Study
Authors: Seaton Sarah E. , Rankin Judith , Cavero‐Carbonell Clara , Garne Ester , Gissler Mika , Loane Maria , Neville Amanda J. , Santoro Michele , Tan Joachim , Tucker David , Morris Joan K. 
Published: February 2025

ABSTRACTBackgroundGlobally, Down syndrome is the most common chromosomal anomaly, often co‐occurring with cardiac or gastrointestinal anomalies. There is a lack of robust data on specific healthcare needs of children with Down syndrome compared to children with other major congenital anomalies.ObjectivesTo quantify the healthcare needs of children with Down syndrome in the first year of life compared to children with major congenital anomalies in a large population‐based cohort across Europe.MethodsThe EUROlinkCAT study was a multicentre data linkage study between congenital anomaly registries in Europe and hospital and mortality databases. Children born between 1st January 1997 and 31st December 2014 were included. Summary statistics were used to compare differences between children (those with Down syndrome compared to all major anomalies) and regions. Random‐effects meta‐analysis was used to pool results related to survival, need for intensive care and ventilation support.ResultsA total of 3554 children were born with Down syndrome out of 89,081 children with major congenital anomalies. The pooled 1‐year survival was 95.4%. In every region, > 80% of children with Down syndrome had a hospital admission excluding the birth admission. Hospital length of stay in the first year was higher for children with Down syndrome compared to those with all anomalies (median: 14 versus 7 days). Despite having similar need for ventilation support (9.7% vs. 8.4%), children with Down syndrome had higher rates of intensive care admission than all children with anomalies (24.8% vs. 13.0%).ConclusionsThere is a high need for hospital care for children born with Down syndrome in the first year of life. Future work should continue to explore the long‐term prognosis for children with Down syndrome to ensure their care needs are met.
Blue and green light‐induced release of swarmers in Petalonia fascia (Ectocarpales, Phaeophyceae)
Authors: Hiyama Tsunami , Yoshikawa Shiya 
Published: February 2025

SUMMARYUnderstanding the environmental factors that influence the release of eggs and swarmers, including gametes, zoospores and unsexual swimming cells, is essential for deciphering the survival strategies of brown algae. In the present study, we investigated the mechanisms underlying the light‐induced release of swarmers in Petalonia fascia. We found that swarmer release was triggered by light, especially blue and green light, with red light having a significantly smaller effect. Swarmer release was not directly affected by photosynthesis. In addition, the duration of light exposure was crucial: even when the total number of photons was low, a longer exposure time resulted in a higher release rate of swarmers. This result suggests that a minimum light exposure time is necessary for swarmer release. We also investigated the influence of a circadian rhythm on swarmer release. Under continuous light conditions, swarmers were released at subjective dawn, thus indicating a circadian rhythm influence. By contrast, no release occurred at subjective dawn in continuous darkness. This result suggests that light is necessary to trigger release, even when circadian rhythms are involved. Our findings, which demonstrate that light quality, exposure time and circadian regulation are critical factors for swarmer release in P. fascia, provide new insights into how environmental cues influence reproductive processes in brown algae.
Basel III Regulations and Financing Decisions of Nonfinancial Firms: The South African Evidence
Authors: Lemma Tesfaye T. , Machokoto Michael , Gwatidzo Tendai 
Published: February 2025

ABSTRACTThis study examines the impact of the Basel III regulatory framework on financing decisions within South Africa's real sector. Using a sample of 2045 firm‐year observations spanning the years 2011–2015 and employing the difference‐in‐differences approach, we find a significant decrease in debt financing and debt maturity for firms deemed ‘constrained’ relative to ‘unconstrained’ firms in the post‐Basel III implementation period. Further analyses suggest that the Basel III regulatory framework has a persistent effect on financing decisions in the real sector. Our findings indicate that the Basel III regulatory framework reduces leverage and debt maturity, especially for constrained firms.
SDG8 and HUB2 depositing euchromatin histone marks play important roles in meiosis and crossing‐over regulation
Authors: Singh Amit Kumar , Chowdary K.V.S.K. Arjun , Shen Wen‐Hui 
Published: February 2025

SUMMARYHistone modifications play critical roles in plant growth and development. Crossing‐over (CO) during meiosis, which constitutes a fundamental process ensuring sexual transmission of genetic material to the next generation and, meanwhile, generating diversity within species by creating new chromosome/allele combinations, occurs predominantly in euchromatin, which is enriched in active histone marks such as H3K4me3, H3K36me3, and H2Bub1. In plants, it is known that CO hotspots are correlated with H3K4me3 but the role of H3K36me3 and H2Bub1 during meiosis remains elusive so far. Here, we studied the Arabidopsis (Arabidopsis thaliana) sdg8‐1 and hub2‐2 mutants impeded in depositing H3K36me3 and H2Bub1, respectively. Chromosome spreading using 4′,6‐diamidino‐2‐phenylindole (DAPI) staining indicated that male meiotic stages are defective in the sdg8‐1 mutant, and the defect increases synergistically in the sdg8‐1hub2‐2 double mutant. Defects in meiosis, seed formation, and silique length were also observed by RNAi‐knockdown of SDG8 using the meiosis‐specific gene DMC1 promoter. This corroborates to support a bona fide role of active histone marks during meiosis and plant reproduction. Using the tetrad‐based visual reporter lines and immunostaining with antibodies against HEI10 and ZYP1, it was found that synapsis and pairing of homologous chromosomes are abnormal and CO rate increases in sdg8 mutants, pointing to a repressive role of SDG8 in Arabidopsis male meiotic homologous recombination.
The chloroplast‐located HKT transporter plays an important role in fertilization and development in Physcomitrium patens
Authors: Yanez‐Dominguez Carolina , Macedo‐Osorio Karla , Lagunas‐Gomez Daniel , Torres‐Cifuentes Diana , Castillo‐Gonzalez Juan , Zavala Guadalupe , Pantoja Omar 
Published: February 2025

SUMMARYCell survival depends on the maintenance of cell homeostasis that involves all the biochemical, genomic and transport processes that take place in all the organelles within a eukaryote cell. In particular, ion homeostasis is required to regulate the membrane potential and solute transport across all membranes, any alteration in these parameters will reflect in the malfunctioning of any organelle, and consequently, in the development of the organism. In plant cells, sodium transporters play a central role in keeping the concentrations of this cation across all membranes under physiological conditions to prevent its toxic effects. HKT transporters are a family of membrane proteins exclusively present in plants, with some homologs present in prokaryotes. HKT transporters have been associated to salt tolerance in plants, retrieving any leak of the cation into the xylem, or removing it from aerial parts, including the flowers, to be transported to the roots along the phloem. This function has been assigned as most of the HKT transporters are located at the plasma membrane. Here, we report the localization of the HKT from Physcomitrium patens to the thylakoid membrane, reminiscent of the prokaryote origin of these family of transporters. Mutation of PpHKT leads to several alterations in the phenotype of the organism, including the lack of sporophyte formation, and changes in expression of many genes. These alterations suggest that the breakdown in chloroplast ion homeostasis triggers a signalling cascade to the nucleus to communicate its status, being important for the moss to complete its life cycle.
Short‐term complications of internal versus external fixation of closed diaphyseal tibial fractures in 95 skeletally immature dogs
Authors: Chitty Jake W. , Sharp Callum A. T. , Low Daniel , Chapman Thomas , Singleton David , Murdoch Andrew , Aldridge Paul 
Published: February 2025

AbstractObjectiveTo determine the influence of fixation method (internal vs. external) on short‐term postoperative complications of closed diaphyseal tibial fractures in skeletally immature dogs.Study designRetrospective observational multicenter study.Animal populationSkeletally immature dogs stabilized with internal fixation (IF) via plate osteosynthesis (n = 59) and external skeletal fixation (ESF) (n = 36).MethodsMedical records from skeletally immature dogs with closed tibial diaphyseal fractures were reviewed. Data collected included signalment, fracture morphology, etiology, fixation technique, surgeon status, complications, time to discharge and time to final discharge.ResultsThe total complication rate for IF was lower at 20.3% (p < .001, CI: 11.0–32.8) compared to ESF at 55.6% (CI: 38.1–72.1). A total of 95% of complications were considered major for external fixation versus 75% for internal fixation. Multivariable analysis revealed decreased odds of a postoperative short‐term complication when a closed tibial diaphyseal fracture was stabilized with IF compared to ESF (p = .004, OR: 0.2, CI: 0.09–0.63). The median time to final discharge for ESF was 4 weeks (range: 2–13) and for IF was 6 weeks (range: 4–32) (p = .01).ConclusionESF had a higher rate of short‐term complications than IF, primarily due to pin‐tract morbidity. The complication rate was 35.3% higher for ESF than for IF.Clinical significanceSurgeons should consider the use of IF over ESF for skeletally immature dogs to reduce the risk of major complications.
Impact of resistance and endurance exercise training on femoral artery function: sex differences in humans
Authors: Green Daniel J. , Thomas Hannah J. , Marsh Channa E. , Lester Leanne , Naylor Louise H. , Haynes Andrew 
Published: February 2025

AbstractExercise has direct and indirect anti‐atherogenic impacts on arterial function and health in humans. Few studies have directly compared the impacts of different commonly adopted exercise approaches on femoral artery function. We hypothesized that, owing to its direct impact via sustained increases in shear stress, endurance (END) training would have larger impacts on arterial diameter and function than resistance (RES) training. Thirty‐nine young, healthy participants (age 26.9 ± 6.2 years, 22♀) completed 12 weeks of both RES and END training in random order, separated by a 12 week washout. Resting femoral artery diameter and flow‐mediated dilatation (FMD) were collected before and after each exercise intervention. END training was associated with an increase in both FMD (Δ1.61 ± 3.09%, P = 0.005) and resting diameter (Δ0.15 ± 0.29 mm, P = 0.004). Neither resting diameter nor FMD increased following RES. However, sex difference analysis revealed that males increased FMD following RES (Δ2.21 ± 3.76%, P = 0.015), whereas no RES change was evident for females. Following END, both males and females increased FMD (♂, Δ1.11 ± 1.65%; ♀, Δ1.88 ± 3.67%; both P = 0.025), with males also showing an increase in resting arterial diameter following END (Δ0.23 ± 0.2 mm, P < 0.001). Group data revealed that END has greater impacts than RES on femoral artery diameter and flow‐mediated functional responses, which are endothelium mediated and nitric oxide dependent. Males exhibit beneficial impacts in response to both END and RES, whereas females respond predominantly to END. Our findings suggest that arterial adaptation to exercise might be influenced by exercise modality and sex.
imageKey points
Exercise has anti‐atherogenic effects and lowers the risk of cardiovascular diseases. This is mediated, in part, by the direct haemodynamic impacts of exercise on arterial function, structure and health. Different modalities of exercise have distinct effects on arterial haemodynamics, but few studies have directly compared, within subjects and using a cross‐over design of trial, the relative impacts of distinct forms of exercise training on arterial adaptation.
In this study, endurance training increased baseline femoral artery diameter and flow‐mediated dilatation, which is endothelium dependent and mediated by nitric oxide. Resistance training had a beneficial but lesser impact.
Females and males were responsive to endurance training, but only males responded positively to resistance training in this study.
These results show that changing the training mode modifies training‐induced arterial adaptation; this has implications for the optimization of exercise prescription for individual benefit.
Sensitivity Analysis Based on the Fisher Information Matrix Applied to Systems With Random Design Inputs
Authors: Andrade Luis , Langley Robin , Yang Jiannan 
Published: February 2025

Abstract
Uncertainties in the parameters adopted during the design process make it challenging to design against the reliability of an engineering system. The identification of parameters that are more sensitive to uncertainties is carried out by a sensitivity analysis of the distribution of the output variables. In this context, we have explored the relation between the Fisher information matrix (FIM) and the design entropy, to develop a framework to analyze the degree of change of the probability of failure and entropy as a result of the variation of input parameters. It is found that the changes in the entropy and probability of failure, associated to the variation of the parameters of the distribution of the input variables, are linear combinations of the eigenvalues of the FIM and the projections of the eigenvectors onto the sensitivity vectors, respectively. As an application, the FIM-based sensitivity analysis is performed from Monte Carlo simulations in a physical dynamic structure subjected to random design parameters drawn from Gaussian and Gamma distributions.
Error Propagation Analysis of Kinematic Quantities for Robots and Mechanisms
Authors: Cantún-Avila K. B. , Peón-Escalante R. , Montoya J. A. , Peñuñuri F. 
Published: February 2025

Abstract
We introduce a comprehensive methodology for calculating the propagation of errors in kinematic quantities up to the jerk for robotic systems and mechanical linkages. Our study utilizes two distinct computational approaches: a deterministic method that relies on derivative calculations, and a stochastic method that utilizes Monte Carlo simulations. Kinematic quantities are computed using dual numbers while the variation in the parameters is computed using the complex step approximation method, as well as with the use of dual numbers to include the general case of a function of complex variables. Although the deterministic approach is generally more efficient, the stochastic method stands out for its simplicity and ease of implementation. The efficacy of our methodology is demonstrated through practical applications. We perform error propagation analyses up to the jerk for planar and spherical four-bar (4R) mechanisms and a revolute–cylindrical–revolute (RCR) robot manipulator, highlighting its versatility across different mechanical systems.
Improved Multi-Objective Coati Optimization Algorithm for Optimizing Energy Efficiency and Thermal Comfort in Chilled Water Systems
Authors: Feng Zengxi , Liu Xuefeng , Zhang Xian , Lu Shuai , Wang Bo , Liu Li , Quan Wei , An Jianhu , Wang Chang , Kang Limin 
Published: February 2025

Abstract
As the main energy consumption part of the central air-conditioning systems, the energy saving of the chilled water system is particularly crucial. This system realizes heat exchange with indoor air by delivering chilled water to air-conditioning units, effectively regulating indoor temperature and humidity to ensure thermal comfort. In this article, an improved multi-objective coati optimization algorithm (IMOCOA) is used to optimize the operating parameters and thermal comfort environment parameters of chilled water systems to improve thermal comfort and reduce energy consumption. The algorithm introduces chaotic mapping to enhance search diversity, balances global and local search capabilities through Levy flight and Gauss variation strategies, and uses location greedy choices to help coatis jump out of local optima. To verify the optimization effect of IMOCOA, a multi-objective optimization model was established, combining the energy consumption model of the chilled water system and the simplified thermal comfort model. Key parameters, including chilled water supply temperature, pump speed ratio, indoor temperature, and relative humidity, are optimized. The simulation results from the experiments show that the average energy-saving rate of the chilled water system using IMOCOA is 7.8% and thermal comfort is improved by 19.6%. Compared to other optimization algorithms, this method demonstrates a better optimization effect.