bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study of a novel micro‐cyclonic air flotation device for enhanced oil removal from wastewater
Authors: Yan Zhong , Zhu Xiaoli , Liu Pengfei , Lv Rui , Dai Xinhe , Song Guosheng , Wang Zhenbo 
Published: February 2025

AbstractAs global oilfields advance into mid‐to‐late development stages, the produced fluids contain increasingly high water content, leading to substantial wastewater volumes. Existing oily wastewater treatment systems face challenges in meeting stricter discharge standards. To address this issue, this work proposes a micro‐cyclonic air flotation separator that integrates cyclonic and flotation technologies to enhance oil removal efficiency. An experimental setup was designed to systematically investigate the effects of structural and operational parameters on bubble formation and oil removal in a DN100 single‐tube micro‐cyclonic flotation device. Key operational parameters were selected, and structural parameters were optimized to support the development of a compact, high‐efficiency separator for oily wastewater treatment. The experimental results revealed that increasing dissolved air pressure reduces mean bubble size, increases bubble number density, and raises gas holdup. Conversely, as air flow rate increases, the mean bubble size grows, the number density initially rises before decreasing, and gas holdup follows a similar trend. Optimal structural parameters were determined, under which the device demonstrated excellent oil removal performance across an oil concentration range of 200–1000 mg/L, achieving a maximum removal efficiency of 85.69%.
GDF15 Analogues Acting as GFRAL Ligands
Authors: Di Santo Andrea , Tarchi Livio , Villa Gianluca , Castellini Giovanni , Ricca Valdo , Squecco Roberta , Papini Anna Maria , Real‐Fernandez Feliciana , Rovero Paolo 
Published: February 2025

AbstractGrowth differentiation factor 15 (GDF15) is a TGF‐β superfamily member involved in diverse physiological and pathological processes. It is expressed in various tissues and its circulating levels rise during exercise, aging, pregnancy, and conditions such as cancer, cardiovascular disease, and infections. The biological activities of GDF15, including anorexia and cachexia, are primarily mediated through the GFRAL receptor, localized in the brainstem and functioning via RET co‐receptor recruitment. This signaling is crucial for energy homeostasis and nausea induction. Recent studies suggest a broader GFRAL distribution, potentially explaining GDF15′s distinct roles. These findings sparked interest in leveraging GDF15‐GFRAL pathways for therapeutic development. Two primary strategies include GDF15 analogues as GFRAL agonists for obesity treatment and GDF15‐derived peptides as antagonists to counteract cancer‐induced cachexia and related disorders. This review highlights advancements in understanding GDF15‐GFRAL signaling and its implications, summarizing bioactive GDF15‐derived molecules, their pharmacological applications, and offering insights into novel treatment avenues for GDF15‐associated conditions.
Geometrical and Electronic Structure of Fluorinated and Non‐Fluorinated Platinum(II) Tetraphenylporphyrin Complexes
Authors: Kurochkin Ivan Yu. , Giricheva Nina I. , Ol'shevskaya Valentina A. , Zaitsev Andrey V. , Girichev Georgiy V. , Mitzel Norbert W. 
Published: February 2025

AbstractThe composition of the saturated vapors of two platinum complexes with the macrocyclic ligands 5,10,15,20‐tetraphenylporphyrin (PtTPP) and 5,10,15,20‐tetrakis(pentafluorophenyl)porphyrin (PtTF5PP) and their structures were determined by synchronous gas‐phase electron diffraction/mass spectrometry (GED/MS). These porphyrin complexes are those with the heaviest metal atom in the coordination cavity that have been structurally investigated in the gas phase. The mass spectra confirm the presence of a single molecular form of each, PtTPP (T=629 K) and PtTF5PP (T=597 K). Their structures can serve as references for related complexes in the crystalline state or solutions. Differences between the geometries of PtTPP and PtTF5PP in the crystalline and gaseous states include a significant deformation of the tetrapyrrole macrocycle in solid PtTPP. The experimental Pt−N bond lengths of both complexes are in agreement with quantum chemical calculations (DFT/B97D/ECP(Pt)) taking into account relativistic effects. The effect of lanthanide contraction is evident from the similarity of the Pd−N and Pt−N internuclear distances of analogous compounds. The strong electron density transfer from the porphyrin backbone to the metal ion and the resulting low effective positive charge on the platinum atom, studied by NBO and QTAIM methods, helps to rationalize the high catalytic activity of such platinum compounds.
Conserved cis‐acting motifs and localization of MFT2 transcripts and MFT2 protein in barley and rice
Authors: Utsugi Shigeko , Kawahigashi Hiroyuki , Tagiri Akemi , Kikuchi Rie , Mishina Kohei , Morishige Hiromi , Nakamura Shingo 
Published: February 2025

AbstractPre‐harvest sprouting, in which grain germinates while still on the spikes, causes substantial yield and quality losses, particularly in regions where the rainy season and harvest times overlap. Breeders have used a natural mutation in the A‐box motif in the promoter of wheat (Triticum aestivum) MFT2 gene on chromosome 3A (TaMFT‐3A) to prevent pre‐harvest sprouting in wheat cultivars in East Asia. Here, we examined the barley (Hordeum vulgare) and rice (Oryza sativa) orthologs of TaMFT‐3A. RNA in situ hybridization showed that the rice and barley orthologs are primarily expressed in the scutellum, indicating that these three MFT2 genes have a common expression pattern during seed development. Analysis of the cis‐acting regulatory elements of their promoter sequences showed that the promoters share eight seed‐specific cis‐acting RY motifs and a binding site for B3‐domain transcription factors, the main regulators of seed development. Moreover, we found tandemly repeated A‐box motifs in the promoters of TaMFT on chromosomes 3B and 3D, but a single motif on chromosome 3A, possibly explaining why the A‐box motif mutation in TaMFT‐3A increases dormancy. Our immunohistochemical observations of green fluorescent protein (GFP)‐tagged MFT2 in transgenic rice plants detected rice MFT2 (OsMFT2)‐GFP in the scutellum and the scutellar epithelium, which is an important tissue for initiating germination. These findings improve our understanding of the role of MFT2, providing information for reducing pre‐harvest sprouting in cereals.
Research Status and Development Trend of Greenhouse Gas in Wetlands: A Bibliometric Visualization Analysis
Authors: Zhu Gege , Wang Yan , Huang Anshu , Qin Yingying 
Published: February 2025

ABSTRACTWith the intensification of global warming, wetland greenhouse gas (GHG) emissions have attracted worldwide attention. However, the scientific understanding of wetland GHGs is still limited. To gain a comprehensive and systematic understanding of the current research status and development trends in wetland GHGs. We selected 1627 papers related to wetland GHG research from the Web of Science Core Collection database and used the bibliometric visualization analysis method to reveal the annual publication, main core research forces, research hotspots, and trends in this field. The results showed that the research in this field shows a steady upward trend. United States research institutions and scholars play a key role in this field. The research on “climate change” based on three major wetland GHGs (carbon dioxide (CO2), methane (CH4), and nitrous oxide (N2O)) has been continuously gaining popularity. In recent years, “water” has become an emerging core topic. More and more studies have focused on enhancing wetland pollutant treatment capacity, improving wetland ecosystem productivity, maintaining water level stability, strengthening blue carbon sink function, exploring remote sensing applications in wetlands, and promoting wetland restoration to reduce GHG emissions. Furthermore, we discussed the influencing factors of the emission of CO2, CH4, and N2O in wetlands and summarized the potential methods to reduce GHG emissions. The findings provide scientific guidance and reference on wetland sustainable development and GHG emission reduction.
Intraspecific scaling of home range size and its bioenergetic association
Authors: Byrnes Evan E. , Hounslow Jenna L. , Heim Vital , White Clemency E. , Smukall Matthew J. , Beatty Stephen J. , Gleiss Adrian C. 
Published: February 2025

AbstractHome range size and metabolic rate of animals are theorized to scale in relation to body mass with similar exponents. This expectation has only been indirectly tested using lab‐derived estimates of basal metabolic rate as proxies for field energy requirements. Therefore, it is unclear if existing theory aligns with observed patterns of home range scaling since field metabolic rates may scale differently than basal metabolic rates. We conducted the first direct field test of the relationship between home range and metabolic rate allometry. Using acoustic telemetry, we simultaneously measured the home range sizes and field metabolic rates of lemon sharks (Negaprion brevirostris) spanning one order of magnitude in body mass and compared the allometric scaling exponents of these traits. Similarity between allometric scaling exponents confirmed an expected strong association between metabolic rate and home range size. However, a nonsignificant but negative association between standard metabolic rate (SMR) and home range size suggests a complex relationship between metabolism and home range, contrasting previous assumptions of a positive relationship. Nevertheless, an overall positive association between home range size and total metabolic rate persisted, driven by a strong association between active energy expenditure and home range size. These findings underscore the intricate relationship between energetics and home range size, emphasizing the need for additional direct field investigations and the potential for modern tagging technologies to gather relevant data.
Pre‐Season Energy Deficiency Predicts Poorer Performance During a Competitive Season in Collegiate Female Long‐Distance Runners
Authors: Lundstrom Emily Ann , Williams Nancy I. , Allaway Heather C. M. , Salamunes Ana Carla Chierighini , Souza Mary Jane De 
Published: February 2025

ABSTRACTFemale distance runners are at a high risk for chronic energy deficiency (ED). ED during predominantly high‐volume and/or high‐intensity training phases may compromise performance. The relationship between pre‐season energy status and running performance in female runners across a season is unclear. To test if energy status as defined by resting metabolic rate ratio (RMRratio) is associated with running performance, female collegiate distance runners (18–25 yr; n = 38) were assessed across 10–12 wks. Energy status, body composition, and 5 km time trial (measure of performance) were assessed pre‐ and post‐competitive season. Runners were categorized at baseline based on pre‐season measured‐to‐Cunningham1991‐predicted RMRratio: metabolically suppressed (SUP: RMRratio < 0.92, n = 12) and energy replete (NSUP: RMRratio ≥ 0.92, n = 26). Repeated measures ANOVA tested effects of pre‐season RMRratio groups, time, and group*time on performance. Linear regression analysis tested whether factors (body composition or total triiodothyronine, TT3) predicted performance across the season. Twenty‐one runners (19.6 ± 0.2 yr, 20.2 ± 0.4 kg/m2) completed pre‐ and post‐season performance runs. Groups had similar body mass, body mass index, percent body fat, and lean body mass. ANOVA revealed a significant group effect of RMRratio on running performance, but no effect of time or group*time. SUP had slower 5 km time trial performance compared to NSUP (22.4 vs. 20.4 min, p = 0.04). Controlling for post‐season VO2max, pre‐season TT3 predicted post‐season 5 km times (R2 = 0.614, p = 0.001). Pre‐season energy deficient female runners exhibited poorer running performance during a collegiate competitive season compared to pre‐season energy replete runners. Early detection of metabolic compensation in runners may be necessary for optimal performance across a competitive season.
Hygroscopic cycle for enhanced water efficiency in thermal power plants
Authors: Ríos‐Fernández Juan Carlos , Fernández‐Pacheco Víctor Manuel , Manfredi Alessia , Rubio‐Serrano Francisco Javier , Gutiérrez‐Trashorras Antonio José 
Published: February 2025

AbstractThis article presents a methodology for calculating the potential for water savings when replacing the Rankine cycle with the hygroscopic cycle in power plants. The savings were analyzed in thermal power plants with different generating units (diesel, gas, steam, and combined cycle), different cooling systems (seawater open cycle, adiabatic cooling, and cooling tower), and in different climatic zones. The results indicated a maximum average saving of 1.83 m3/MWh. The considerable water savings serve to reinforce the case for the implementation of HCT, particularly in regions characterized by arid climates and water scarcity. A reduction in water consumption, coupled with the prevention of the return of hot water to sensitive ecosystems, can serve as effective mitigation strategies for environmental problems. Moreover, the minimal water consumption required for this process makes it feasible to construct thermal power plants and generate electricity in regions with limited water resources. The HCT approach facilitates the generation of energy in regions previously deemed unsuitable for thermal power plants, thereby representing a significant advancement in economic and developmental terms for these areas.
Prognostic Factors for Free Flap Failure in Head and Neck Reconstruction
Authors: Hennocq Quentin , Caruhel Jean‐Baptiste , Benassarou Mourad , Bouaoud Jebrane , Chaine André , Girod Angélique , Graillon Nicolas , Testelin Sylvie , Amor‐Sahli Mélika , Foy Jean‐Philippe , Bertolus Chloé 
Published: February 2025

ABSTRACTBackgroundThe failure rate of free flaps varies from 0.8% to 10.6% in the literature in head and neck reconstruction. The primary objective was to identify prognostic factors for free flap failure.MethodsWe prospectively included all consecutive free flaps performed between August 2021 and January 2024, and used a multivariate Cox proportional hazard model.ResultsWe included 307 free flaps, performed on 274 patients. Age, cardiovascular risk, radiotherapy history, type of flap, type of arterial anastomosis, and ischemia duration were not statistically linked to the risk of flap failure. In multivariate analysis, a venous anastomosis to the anterior jugular vein or to the superior thyroid vein were associated with an increased risk of flap failure, such as per‐ or postoperative revision of the anastomoses.ConclusionsThe choice of venous anastomosis, appear to have a greater influence on the success or failure of a microvascularized transfer than patient characteristics.
Diagnostic and Prognostic Value of Serum Golgi Protein 73 in Patients With Hepatitis B Virus‐Associated Acute‐on‐Chronic Liver Failure
Authors: Xu Zheng‐ju , Xu Tao , Ye Qiao‐xia , Li Yong‐fei , Yang Tian‐huang , Zhang Xiao‐man , Lin Hui , Liu Hui‐guo , Huang Zhi‐jie , Shen Jian‐kun 
Published: February 2025

ABSTRACTBackground and AimsThe prognosis and severity of hepatitis B virus‐associated acute‐on‐chronic liver failure (HBV‐ACLF) cannot be well‐identified by serum biomarkers. The present study aims to determine the role of serum Golgi protein 73 (GP73) in predicting the prognosis and severity of liver necrotizing inflammation induced by HBV‐ACLF.MethodsA total of 427 chronic HBV‐infected patients were included for the present study. Among these patients, 179 patients had chronic hepatitis B (CHB), 96 patients had HBV‐related liver cirrhosis (LC), and 152 patients had HBV‐ACLF. The baseline and dynamic changes in serum GP73 levels were measured and compared in CHB, LC and HBV‐ACLF patients.ResultsThe serum GP73 levels were significantly greater in HBV‐ACLF patients when compared to CHB and LC patients. Furthermore, serum GP73 demonstrated excellent performance in distinguishing HBV‐ACLF from CHB and LC, with an area under the curve of 0.969 and 0.824, respectively. In the logistic regression analysis, a high GP73 level was identified as an independent risk factor associated with death within 3 months, and the optimal cut‐off level was 274.59 ng/mL. The serum GP73 levels significantly decreased and remained stable at approximately 6 months for survivors.ConclusionSerum GP73 may serve as a valuable biomarker for the diagnosis and prognosis prediction of HBV‐ACLF patients.
Awe and aesthetics: Conundrums of creation and consumption
Authors: Hagtvedt Henrik 
Published: February 2025

AbstractPrior scholarship characterizes awe as an aesthetic emotion, and the rich and growing aesthetics literature can help illuminate the role of awe in consumer psychology. The current commentary draws on this literature, as well as Keltner's conceptual analysis of awe, to highlight findings and remaining questions pertaining to awe in the realm of consumption. Marketing activities such as branding and promotion, store design, and product development present opportunities to awe consumers, yet awesome consumption experiences are rare. The current work discusses characteristics of awe‐inspiring products and brands, the tendency of awe to increase or decrease consumption, relevant individual differences between consumers, and the nature and evolutionary background of awe and aesthetics.
Longitudinal assessment of cerebral infarcts and small vessel disease using magnetic resonance imaging in antiphospholipid syndrome: A single‐centre retrospective study
Authors: Tan Yishi , Doyle Andrew J. , Kumar Jayant , Somerville Peter , Faruqi Uzma , Danaee Anicee , Luo Pu‐Lin , Hunt Beverley J. , Breen Karen A. 
Published: February 2025

AbstractIntroductionStroke is the most frequent arterial thrombosis in antiphospholipid syndrome (APS) with high rates of recurrence.Methods and patientsA retrospective, single‐centre 10‐year review of patients with APS having sequential cerebral magnetic resonance imaging (MRI) was performed to describe ischaemic features in APS and associated disease risk factors and progression over time.ResultsA total of 120 patients and 307 scans were included with 67% of patients receiving vitamin K antagonists (VKA). Note that 65% of patients had baseline ischaemic features with white matter hyperintensities (WMH), as a feature of small vessel disease (SVD), seen in 79% of abnormal scans. Fifteen percent of patients had progressive ischaemic changes with 83% demonstrating progressive WMH and 33% new infarcts (predominantly lacunar) on sequential scans. Progression‐free survival for progressive ischaemia was 88% at 5 years. Multivariate analysis showed longer follow‐up was a risk for developing progressive ischaemia (odds ratio [OR] 1.43, 95% confidence interval [CI] 1.13–1.86, p = 0.005). Hypertension (56% vs. 30%, p = 0.04) and ischaemic heart disease (22% vs. 6%, p = 0.04) were more prevalent with progressive ischaemia. There was no difference in progression or bleeding events according to VKA therapeutic intensity.DiscussionThese results show SVD is a common feature of APS using MRI with progressive changes despite anticoagulation. Traditional risk factors for cerebrovascular disease were associated with progression.
Anticoagulation control of warfarin in anticoagulation medication therapy adherence clinics
Authors: Mazlan‐Kepli Wardati , Mohamed Sahimi , Nik‐Ismail Nik‐Azlean , R‐Nagarajah Jivanraj ,   Clinical Pharmacy Working Committee (Cardiology Subspecialty), Pharmaceutical Services Programme, Ministry of Health Malaysia
Published: February 2025

AbstractBackgroundWarfarin therapy remains essential in anticoagulation management and its quality is measured by the time in therapeutic range (TTR). In Malaysia, some healthcare centres provide the Anticoagulation Medication Therapy Adherence Clinic (ACMTAC) service for warfarin management, which is managed by pharmacists.AimTo evaluate overall TTR and to analyse the occurrence of thromboembolic and bleeding complications in warfarin patients.MethodThis cross‐sectional, retrospective cohort study included patients who received warfarin treatment over a 3‐year period (2019–2021). Data were collected from 49 healthcare centres in Malaysia with ACMTAC services. TTR was calculated using the Rosendaal method from international normalised ratio (INR) data acquired across these centres. TTR ≥ 65% was defined as good control of anticoagulation therapy. Ethical approval was granted by the Medical Research and Ethics Committee, Ministry of Health Malaysia (Reference no: NMRR‐ 21‐779‐59275) and the study conforms with the Declaration of Helsinki.ResultsThe mean age (±standard deviation [SD]) of the 1464 included patients was 60.3 (±13.1) years, and 732 (50.0%) were male. Atrial fibrillation (65.7%) and valve replacement (23.1%) were the main indications for warfarin therapy. From 2019 to 2021, the annual mean TTR (±SD) were 63.1% (±24.5%), 64.0% (±25.0%), and 64.1% (±26.3)% respectively. For three consecutive years, more than 49% of patients achieved good control of anticoagulation therapy. Among the 49 centres, over 24 (49.0%) achieved a mean TTR of ≥65%, and the mean TTR varied significantly between centres (p < 0.001). The occurrence of bleeding and thromboembolic events was 227 (15.5%) and 15 (1.0%) respectively.ConclusionIn Malaysia, the anticoagulation control of warfarin under ACMTAC management is moderate, with about half of patients demonstrating good control levels. Over a 3‐year observation period, there was variation in TTR among the centres.
A Protocol for Determination of Proteinogenic Amino Acids in Biological Fluids by the High‐Speed UHPLC‐MS Method: Application on Transgenic Spontaneously Hypertensive Rat‐24 Plasma and Cerebrospinal Fluid Samples
Authors: Piestansky Juraj , Olesova Dominika , Majerova Petra , Chalova Petra , Kovac Andrej 
Published: February 2025

ABSTRACTRecently, proteinogenic amino acids have become very interesting molecules, accompanied by a large variety of metabolic processes in humans and are associated with various diseases. In the era of system biology, including a broad spectrum of associated disciplines (e.g., metabolomics, lipidomics, proteomics, etc.), the possibility of identifying trustworthy biomarkers of diseases becomes much more likely. Changes in amino acid levels in plasma, serum, or cerebrospinal fluid reflect physiological or pathological conditions and, therefore, their regular monitoring can lead to early detection of the occurrence of a disease. Therefore, the exact determination of amino acids in biological fluids is of great importance. However, it is necessary to dispose with an effective, accurate, precise, selective, and robust analytical method. This protocol describes the complex procedure of amino acid analysis based on a combination of UHPLC with single quadrupole MS. The protocol presents a highly reproducible and robust methodology that has already been established in the quality control of biopharmaceuticals and determination of proteinogenic amino acids in urine in our laboratory. Here, the application potential is extended to the most frequently investigated biological fluid, that is, plasma and to the cerebrospinal fluid, which is investigated in many neurological conditions.