bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of the quality of life in patients with atopic dermatitis using the Kazakh version of the questionnaire “Dermatology Life Quality Index”
Authors: Sarybayeva Gulya , Beisebayeva Ulzhan , Almenova Leila , Khabizhanov Askar , Ospanova Saniya , Rysbekova Dinara , Ispayeva Zhanat , Tanabayeva Shynar , Saliev Timur , Fakhradiyev Ildar 
Published: February 2025

Background:
The effectiveness of the Dermatology Life Quality Index (DLQI), translated into Kazakh, for assessing the quality of life of patients with atopic dermatitis (AD) in Kazakhstan, has not yet been evaluated.

Objective:
The aim of the study is to assess the reliability and validity of the Kazakh language DLQI as a tool for assessing the quality of life of patients with AD.

Methods:
This multicenter study involved 883 adult patients of the Kazakh population diagnosed with AD. To assess the quality of life of AD patients, the DLQI questionnaire translated into Kazakh was used.

Results:
The reliability (Cronbach α) of the Kazakh version DLQI questionnaire was −0.924. The average DLQI score for the sample was 10.7 ± 8.2. Nearly 53.8% of patients had mild AD and 35.3% had moderate AD. According to the DLQI questionnaire, the average score increases with rising body mass index: patients who are overweight (11.9 ± 8.5) and those with obesity of the first degree (13.1 ± 9.0) have scores indicating a significant impact of the skin disease on their quality of life, whereas patients with normal weight (10.2 ± 8.0) or underweight (7.9 ± 7.4) experienced a more moderate effect, P = 0.001. Relapses 2 times a year (12.2 ± 8.5) and 3 or more times a year (12.6 ± 8.7) worsened the quality of life relatively more than relapses 1 time per year, P = 0.001. Smoking and alcohol consumption affected the deterioration in the quality of life of patients with AD (P ≤ 0.05). The quality of life of patients with AD in remission according to the DLQI scale was higher, P = 0.001.

Conclusion:
The results demonstrate that the Kazakh language version of the DLQI is a reliable and valid tool for measuring the impact of AD on quality of life. Its applicability in research and clinical settings underscores its versatility. The study underscores the significance of clinical and demographic characteristics, along with the quality of life, for an accurate assessment of disease severity and effective treatment.
A retrospective analysis of factors influencing response to omalizumab treatment in Indian patients with antihistamine refractory chronic spontaneous urticaria
Authors: Prarthana Thammannagowda , Mehta Hitaishi , Bishnoi Anuradha , Parsad Davinder , Kumaran Muthu Sendhil 
Published: February 2025

Background:
Chronic spontaneous urticaria (CSU) presents as a persistent and distressing condition, with varying treatment responses. Omalizumab, a monoclonal anti-IgE antibody, has shown efficacy in managing antihistamine (AH1)-refractory CSU, but its varied response patterns and associated factors remain understudied, particularly in India.

Methods:
We conducted a retrospective study involving 81 antihistamine-resistant CSU patients treated with omalizumab at a tertiary care center in Northern India between 2018 and 2023. Baseline characteristics, treatment response, and adverse effects were analyzed. Patients were categorized into various response groups based on treatment timelines and biomarker correlations.

Results:
We observed 65% achieved symptom cessation (group 1) following a single omalizumab dose, while 21% responded between second and third doses (group 2). A subset (7.4%) necessitated increased dosing frequency (group 3) for symptom control. Additionally, 6.2% showed persistent symptoms despite increased dosing frequency (group 4), exhibiting distinctive biomarker profiles indicative of an autoimmune endotype. Notably, 27.1% experienced exacerbations during treatment, emphasizing the need for tailored management approaches and response expectations.

Conclusion:
Omalizumab demonstrated remarkable efficacy in the treatment of AH1-refractory CSU, with a good safety profile. This study highlights the complexity of treatment response to omalizumab and the potential utility of biomarkers in guiding personalized therapeutic strategies. Further research into biomarker-based endotypes is warranted to optimize CSU management.
Impact of Zinc Phosphide on Hematology, Behaviour and Proximate Composition of Oreochromis niloticus
Authors: Shahzadi Iram , Yaseen Shazia , Khizar Fatima , Farhan Muhammad , Haider Muhammad Irfan , Ismat Nida , Sarwar Muhammad Sajjad , Hussain Majid 
Published: February 2025

Zinc phosphide is a rodenticide, crystalline compound of dark grey color. It is present in many pesticides and when sprayed on plants it gains entry into food and water. Objective: To evaluate the effect of zinc phosphide on the hematology, behavior and proximate composition of Oreochromis niloticus. Methods: In present research, fish were given a dose of zinc phosphide in aquarium for twenty days. Fish were divided into two groups, control, and treatment, each with three replicates. Treatment group was exposed to 1mg/ml of Zinc phosphide given to treatment group twice a day for 20 days continuously. When the experiment was completed fish were anaesthetized, dissected and blood was drawn to evaluate the hematological parameters. Fish activities swimming, gill movement, mortality and morbidity were recorded. Results: Zinc Phosphide exhibited variable impact on proximate composition. There was a significant decrease in values of crude fat and increase in value of crude protein and total ash in comparison to control group. Fish were active during the trial period they exhibited fast movement, no rubbing against the wall, and fish didn't harm each other in the treatment group. Conclusions: According to these results, zinc phosphide havearmful impacts on fish health. As a result, its usage must be carefully regulated to reduce environmental contamination and safeguard aquatic ecosystems.
صكوك المضاربة بوصفها أداة لرأس المال الإضافي في ضوء مقررات بازل ومتطلبات مجلس الخدمات المالية الإسلامية: دراسة فقهية
Authors: مصطفى مضاء , حسن عزنان , زكريا حبيب الله 
Published: February 2025

يهدف البحث إلى دراسة استخدام صكوك المضاربة بوصفها أداة ضمن رأس المال الإضافي للمصارف الإسلامية، من خلال تناول المسائل الفقهية الناتجة عن هذا الاستخدام، واستخلاص الضوابط الفقهية التي ينبغي اتباعها عند القيام بذلك. وتكمن أهمية البحث في كونه يركز على تحليل القضايا الفقهية المتعلقة بإصدار هذا النوع من الصكوك، في ضوء آخر المستجدات الطارئة على مقررات بازل 3، ومعياري مجلس الخدمات المالية الإسلامية الخامس عشر والثالث والعشرين. وستعتمد الدراسة على المنهج الاستقرائي الهادف إلى تقصي القضايا الفقهية المتعلقة باستخدام صكوك المضاربة ضمن رأس المال الإضافي، فضلًا عن المنهج التحليلي الاستنباطي الذي يسعى إلى تحليل الآراء الفقهية المستقاة من الكتب الفقهية والدراسات والبحوث والمعايير الشرعية ذات الصلة، ومن ثم الاستناد إلى القول الراجح منها. وقد توصلت الدراسة إلى أن أموال حملة صكوك المضاربة ضمن رأس المال الإضافي تستثمر في الوعاء الاستثماري العام للمصرف الإسلامي، ويتحمل حملة الصكوك الديون والالتزامات المرتبطة بالوعاء الاستثماري العام بنسبة حصتهم فيه، ويتقاسمون الأرباح وفق النسبة المتفق عليها، ولذلك فهم في مرتبة مساوية لمرتبة المساهمين، ويترتب على ذلك عدم جواز تضمين أي شرط يسمح بفرض قيود على توزيع أرباح حملة الصكوك، والاستئثار بها إذا ما انخفضت نسبة حقوق الملكية الخاصة بالمصرف الإسلامي إلى حد معين، فضلًا عن إمكانية الاستغناء عن آلية تحويل صكوك المضاربة إلى أسهم عادية.
ALLERGIES DOCUMENTATION IN HMIS HISTORY OF PATIENTS ADMITTED IN GASTROENTEROLOGY AND PULMONOLOGY WARD AT LADY READING HOSPITAL, MEDICAL TEACHING INSTITUTE – PESHAWAR
Authors: Khan Muhammad Hamza , Muhammad Khalid Shah  , Arshad Mehmood  , Usman Fazal Muhammad  , Ahmed Mustafa Khawaja  , Jamal Tauqir  , Azra Jebin  , Mah Noor Durani  , Bilal Ahmed  
Published: February 2025

Allergy is defined as an immune-mediated inflammatory response to common environmental allergens that are otherwise not harmful. Allergies included food, drug and unlisted allergies respectively. Hypersensitivity is an exaggerated immune response to antigens, manifesting from minor (atopic dermatitis and rhinitis) to dangerous manifestations such as anaphylaxis which can be life-threatening. The clinical audit aimed to confirm the proper documentation of allergies in the medical history section of the hospital management information system (HMIS) of patients admitted to the Gastroenterology and Pulmonology Ward of Lady Reading Hospital Medical Teaching Institute – Peshawar. Accurate documentation of allergies is important for patient safety and helps clinicians avoid potential allergic reactions during treatment
Perfil nutricional e sociodemográfico de idosos com demências hospitalizados em uma unidade especializada em Cuidados Paliativos
Authors: Alves Alicia de Morais , Lima Lais da Silva , Freire Patrícia Barbosa , Albuquerque Suziane Anozi Emerich de 
Published: February 2025

Introdução: Houve crescimento das síndromes demenciais, sendo estas uma das mais incapacitantes em idosos. A abordagem dos cuidados paliativos torna-se imperiosa, por visar melhorar a qualidade de vida do paciente/família com uma doença grave que ameace a continuidade da vida. Este trabalho visou descrever o perfil nutricional e sociodemográfico de idosos com demências hospitalizados em uma unidade especializada em cuidados paliativos e correlacionar o perfil nutricional dos pacientes ao desfecho clínico. Métodos: Estudo transversal, prospectivo e analítico, com amostra de 46 idosos com demência e idade ≥ 60 anos, internados em um hospital especializado em cuidados paliativos. Foram analisados os dados de caracterização da amostra, aspectos nutricionais, escalas de funcionalidade (PPS e FAST), desfecho clínico e tempo de internação. Resultados: A maioria era do sexo feminino (52,17%), com idade > 80 anos (78,26%), sendo a etiologia mais frequente a demência de Alzheimer (28,26%) e FAST 7 (78,7%). O diagnóstico nutricional mais verificado foi a desnutrição severa (47,82%), seguida pela moderada (43,48%). A via alimentar prevalente foi a enteral (47,83%), seguida pela oral (41%). Dos participantes, 86,96% foram a óbito durante o estudo. A desnutrição não esteve relacionada ao óbito (p=0,347), entretanto, houve correlação entre o volume enteral prescrito e o desfecho óbito (p=0,031), de modo que volumes menores foram mais frequentes em pacientes com este desfecho. Conclusão: Destaca-se a prevalência de desnutrição em 91,3% da amostra, assim como houve correlação significativa entre o menor volume de dieta enteral e o óbito. Percebe-se desconhecimento por parte dos profissionais de saúde acerca da adequada indicação da via de alimentação nestes pacientes, visto a alta prevalência da dieta enteral, provenientes de unidades que não são especializadas em cuidados paliativos.
ESG nas contratações públicas: implicações da Lei nº 14.133/2021 para a governança sustentável no Brasil
Authors: Gomes Rafaella Christina 
Published: February 2025

A Lei nº 14.133/2021, conhecida como a Nova Lei de Licitações e Contratos, traz implicações significativas para a governança sustentável no Brasil ao incorporar princípios e diretrizes que promovem critérios ESG (ambientais, sociais e de governança) nas contratações públicas. A norma fortalece o papel das compras públicas como um instrumento estratégico para impulsionar políticas de ESG e alcançar objetivos de desenvolvimento sustentável no país. Nesse sentido, o presente artigo tem como objetivos: compreender como a nova Lei de Licitações (Lei 14.133) integra ou pode integrar as práticas de governança sustentável, incluindo a priorização de fornecedores que adotem práticas ambientais e sociais responsáveis; identificar as barreiras legais, culturais e práticas para a efetiva aplicação de ESG nas contratações públicas; e apresentar sugestões de melhoria e reformulação legislativa como a Lei nº 14.133 pode ser aprimorada para melhor incorporar critérios ESG. Para tanto, utiliza-se como metodologia uma pesquisa qualitativa, de cunho descritivo, envolvendo um estudo empírico, com a realização de uma pesquisa documental, por meio da análise de documentos, ou seja, de legislações, bem como a realização da pesquisa bibliográfica, e como técnica de pesquisa, também, é utilizado estudos de caso de países que já utilizam a integração de ESG em suas contratações públicas, , a fim de mostrar que essa integração não só promove sustentabilidade e inclusão, mas também impulsiona inovações no setor privado e fortalece políticas públicas alinhadas aos ODS.
O uso de Isotretinoína no tratamento da acne severa: avaliação do risco de depressão e outras alterações psiquiátricas
Authors: Oliveira Ítalo Carneiro de , Gomes Nelson Pinto , Sampaio Francisco Leonardo de Araújo , Pedro Gustavo de Souza , Gonçalves Thais Gisele Bastos , Duarte Andréa Aparecida de Almeida , Ferreira Rodrigo da Silva , Silva Graziela Giongo da 
Published: February 2025

A acne severa é uma condição dermatológica que afeta negativamente a qualidade de vida dos pacientes, tanto fisicamente quanto emocionalmente. Quando tratamentos convencionais não são eficazes, a isotretinoína é uma alternativa frequentemente utilizada. Embora sua eficácia no tratamento da acne severa seja comprovada, seu uso tem sido associado a efeitos adversos na saúde mental, incluindo depressão, ansiedade e ideação suicida, levantando preocupações sobre a relação entre o medicamento e distúrbios psiquiátricos. O objetivo geral deste estudo é compreender os efeitos psicológicos do uso da isotretinoína no tratamento de acne severa, com foco no desenvolvimento de sintomas como depressão, ansiedade e ideação suicida. Os objetivos específicos incluem investigar o impacto da isotretinoína na saúde mental, explorar os mecanismos químicos relacionados a alterações de humor e sugerir estratégias de monitoramento e apoio emocional durante o tratamento. Este estudo consistE em uma revisão sistemática da literatura, conduzida por meio de bases de dados como PubMed, Scopus e Web of Science. Foram analisados artigos publicados entre 2010 e 2025 que investigaram a relação entre isotretinoína e transtornos psiquiátricos. A pesquisa seguiu as diretrizes PRISMA e incluiu estudos observacionais e ensaios clínicos randomizados. Os resultados indicam que, embora a isotretinoína seja altamente eficaz no tratamento da acne severa, seu uso pode estar relacionado ao agravamento de sintomas psiquiátricos, especialmente em indivíduos com vulnerabilidade emocional. Estudos mostram que alterações nos níveis de neurotransmissores como serotonina e dopamina podem ser um fator contribuidor. No entanto, a relação exata entre o medicamento e os distúrbios psiquiátricos ainda não é totalmente compreendida. O uso de isotretinoína, embora eficaz no tratamento da acne severa, deve ser acompanhado de cuidados psicológicos rigorosos. Pacientes com histórico de distúrbios emocionais devem ser monitorados de perto, e a administração do medicamento deve ser ajustada conforme a necessidade. A colaboração multidisciplinar é essencial para garantir que os benefícios dermatológicos do tratamento não sejam superados pelos riscos psiquiátricos.
COMORBIDADES RESPIRATÓRIAS EM EQUINO ATLETA: RELATO DE CASO
Authors: Teixeira Jhennifer Santos , Hartmann Welington 
Published: February 2025

Houve atendimento clínico a um potro da raça Puro Sangue Inglês, em treinamento para esportes hípicos de velocidade, que apresentava secreção nasal do tipo exsudato mucopurulento, febre, anorexia e intolerância ao exercício, caracterizando quadro de infecção respiratória aguda. Essa condição clínica complexa exemplifica a sobreposição de sintomas frequentes em doenças respiratórias de equinos, agravando o estado geral de saúde e baixo desempenho esportivo. O animal foi submetido a exame clínico e colheita de material para hemograma e antibiograma. Houve isolamento de Staphylococcus sp. nas secreções traqueais, com sensibilidade para azitromicina, ciprofloxacino, doxiciclina, enrofloxacino e gentamicina, enquanto amoxicilina, ampicilina e penicilina demonstraram resistência. A abordagem terapêutica adotada incluiu antibioticoterapia, anti-inflamatórios e terapia inalatória, com resultados promissores, ressaltando a importância de diagnósticos precisos e do manejo ambiental adequado.
DuckDB vs dplyr vs base R
Authors: Turner Stephen 
Published: February 2025

<b>
Reposted from https://blog.stephenturner.us/p/duckdb-vs-dplyr-vs-base-r.
</b>
<em>
<strong>
TL;DR
</strong>
: For a very simple analysis (means by group on 100M rows), duckdb was 125x faster than base R, and 28x faster than readr+dplyr, without having to read data from disk into memory. The duckplyr package wraps DuckDB&#39;s analytical query processing techniques in a dplyr-compatible API.
</em>
Build a Python CLI with Click+Cookiecutter (repost)
Authors: Turner Stephen 
Published: February 2025

<b>
Reposted from the original at https://blog.stephenturner.us/p/python-cli-click-cookiecutter.
</b>
<b>
---
</b>
In the spirit of Learning in Public, I wanted an excuse to explore (1)
<strong>
click
</strong>
for creating command line interfaces, (2)
<strong>
Cookiecutter
</strong>
project templates, and (3) modern tools in the Python packaging ecosystem.
Celestial Resistance
Authors: Rusak Maryia 
Published: February 2025

The essay investigates the application of cosmotechnics in architecture through a case study of a large international construction venture, the Zambia World Bank Education Project. Financed in 1969 by the World Bank together with the Norwegian Agency for International Development (NORAD), the project envisioned the construction of sixty-five new secondary schools in under four years. A Norwegian consultancy company hired for the project proposed a modular semi-industrial building system and a computer-aided system of process management that defined the project’s cosmology. Not surprisingly, expectations of a new computerised modernity did not materialise, and the project was plagued by endless problems that seemed to be divine acts of resistance to which only celestial bodies could provide a solution. However, as this essay argues, these resistances can be considered sites of rupture, where the conflict between different cosmotechnics becomes apparent. Based on original archival documents, the essay interrogates these resistances to universalist ideas of technology and ontological assumptions embedded and perpetuated through the architecture of post-colonial “development” projects. This study serves as a first stepping stone towards further investigations into how Western homogenising technologies could be negotiated and challenged for a more pluralistic technological paradigm.
Modified Scalp Acupuncture for Treatment of Central Nervous System Disorders in Dogs: A Retrospective Cohort Study
Authors: Wong Chee May , Shiau Deng-Shan 
Published: February 2025

Scalp acupuncture (SAP) has demonstrated efficacy for treating central nervous system (CNS) disorders. To improve SAP’s practicality, while maintaining efficacy in dogs, a modified SAP (mSAP) technique was developed. The efficacy of mSAP when added to integrative therapy for CNS disorders above the foramen magnum (e.g. seizures, central vestibular disease, stroke/cerebrovascular accident) was evaluated in 46 dogs in a retrospective study. Dogs were categorized into 2 groups: Test (n=35) received mSAP and integrative treatment, and Control received integrative therapy without mSAP (n=11). Study dogs were assigned a neurological deficit/dysfunction score or seizure severity score before and after 45 days of treatment. Successful recovery was defined: 1) seizure frequency reduction by 2 grade levels or resolution of seizure activity or 2) neurological deficit improvement of 2 grade levels and/or return of ability to stand and walk without assistance. Time-to-recovery (TTR) data (in days) was recorded for dogs who met the criteria for recovery. The effect of mSAP treatment was compared to controls with respect to (1) recovery rate (%) and (2) mean TTR for those who recovered. All but one subject in the Test Group (97.1%) and 7 out of 11 controls (63.6%) met recovery criteria, p=0.009. The mean (SD) TTR in the Test Group was 6.7 (SD 6.2) days which was significantly shorter (p=0.001) than the Control Group mean of 21.0 (SD 12.1) days. Study findings suggest that adding mSAP to integrative treatment may shorten the recovery period for CNS disorders above the foramen magnum in dogs.
Acupuncture Treatment for Headshaking in A Sport Horse with Poor Performance: A Case Report
Authors: Resano-Zuazu María 
Published: February 2025

A nine-year-old Warmblood gelding was presented with a clinical history of irritable behavior when being ridden, tic-like movements of the head and laryngeal hemiplegia. It was noted that clinical signs were exacerbated by intense exercise and sun exposure. Due to the clinical signs observed and exclusion of other etiologies, a suspected conventional diagnosis of trigeminal-mediated headshaking (TMHS) was made. A traditional Chinese veterinary medicine (TCVM) clinical exam was performed. The horse had a Wood personality with a slight dry tongue and deep strong pulse. Palpation of the head and multiple acupoints demonstrated sensitivity. The TCVM pattern diagnosis was Liver Qi Stagnation with Liver Heat, Stagnation of Qi in the Upper Burner (Shang Jiao) and Wind-Heat. Electro-acupuncture treatment was considered but due to safety concerns associated with the horse’s Wood personality, dry needle acupuncture (DNAP) was instituted instead. Acupoints stimulated included: LIV-3, GB-41, BL-18, Da-feng-men, BL-12, GB-20 and BL-17. Treatment also included food therapy (i.e. green vegetables) and a face mask was introduced. Marked clinical improvement was reported by the owner after the first DNAP treatment. One week later, a second DNAP treatment was performed using LIV-3, GB-41, BL-18, Da-feng-men and GB-20. A Spleen Qi Deficiency was diagnosed 3 weeks after the second acupuncture session. This was successfully treated with DNAP at ST-36, BL-20, SI-9 and GB-20. The horse received a total of three acupuncture treatments over the course of a month and then successfully maintained on low stress handling/training practices, along with external protection (i.e. face-nose mask); which has allowed this sport horse to currently train and compete on a regular basis at expected levels.
Sosialisasi Anti Kekerasan di Sekolah Dasar
Authors: Sidiq Mohammad , Larashaty Anindita Aprilliana , Ma’arif Syamsul , Magfira Magfira , Hidayatullah Muh. Syarif , Hafil Moh , Darmayanti Lisda , Renaldi Renaldi , Munir Nuraisa 
Published: February 2025

Artikel Sosialisasi Anti Kekerasan ini membahas upaya pencegahan dan penanganan kekerasan di Sekolah Dasar (SD) sebagai respons terhadap meningkatnya kasus bullying di lingkungan pendidikan. Dengan merujuk pada data yang dirilis oleh Federasi Serikat Guru Indonesia (FSGI), diidentifikasi bahwa bullying merupakan masalah signifikan yang mempengaruhi perkembangan anak. Sosialisasi ini mengeksplorasi berbagai strategi anti-kekerasan yang dapat diterapkan di SD, termasuk pendidikan karakter, pelibatan orang tua, dan pelatihan bagi guru. Selain itu, artikel dan sosialisasi ini menekankan pentingnya menciptakan lingkungan sekolah yang aman dan mendukung, di mana siswa dapat belajar tanpa rasa takut. Hasil dari artikel dan sosialisasi ini diharapkan dapat memberikan wawasan bagi pendidik dan pembuat kebijakan dalam merancang program yang efektif untuk mengurangi kekerasan di sekolah.