bluuebunny/crossref_metadata_2025_split huggingface dataset:
STIMULATION OF OVULATION IN IMMATURE FEMALE RATS USING ORTHOSTERIC AND ALLOSTERIC LUTEINIZING HORMONE RECEPTOR AGONISTS
Authors: Fokina E. A. , Derkach K. V. , Bakhtuykov A. A. , Sorokoumov V. N. , Lebedev I. A. , Morina I. Yu. , Shpakov A. O. 
Published: April 2024

Human chorionic gonadotropin (hCG) and luteinizing hormone (LH) are widely used for the treatment of reproductive disorders and for controlled ovulation induction, but their use is limited by side effects. Allosteric agonists of the LH/hCG receptor, including thieno[2,3-d]thienopyrimidine TP03 developed by us, can become an alternative. TP03 (50 mg/rat, i.p.) when administered to immature female rats treated 48 hours before with Follimag has been shown to increase progesterone levels (maximum 8 hours post-treatment) and induce ovulation, as indicated by the appearance at 24 hours corpus luteum (8.6 ± 0.5 per ovary). In terms of its activity, TP03 is comparable to hCG, although it acts more moderately. In the ovaries, unlike hCG, TP03 does not lead to an increase in the expression of vascular endothelial growth factor, which can cause ovarian hyperstimulation syndrome. Thus, TP03 is a promising drug as an ovulation inducer and ovarian steroidogenesis stimulator.
NEW DATA ON HESPERORNITHIDS (AVES: ORNITHURAE) FROM THE CAMPANIAN OF THE LOWER VOLGA REGION (LATE CRATACEOUS, RUSSIA)
Authors: Zelenkov N. V. , Arkhangelsky M. S. 
Published: April 2024

Taxonomic diversity of the Late Cretaceous Hesperornithidae (Aves: Hesperornithidae) of the European part of Russia and Eastern Europe as a whole remain poorly understood, and the morphology of these large flightless birds is poorly known. New finds of Hesperornithidae in the Karyakino locality (Saratov oblast, Russia) confirm the coexistence of two forms of these flightless seabirds in the Campanian (mid-Late Cretaceous) of the Lower Volga region. For Hesperornis rossicus Nessov et Yarkov, 1993, a femur is described for the first time; it indicates a morphological distinctiveness of this large species as compared to the North American H. regalis Marsh, 1872.
GROWTH INDUCTION OF SOLID EHRLICH ASCITIC CARCINOMA IN MICE AFTER PROTON IRRADIATION OF TUMOR CELLS <i>EX VIVO</i>
Authors: Balakin V. E. , Rozanova O. M. , Smirnova E. N. , Belyakova T. A. , Strelnikova N. S. , Smirnov A. V. , Shemyakov A. E. 
Published: April 2024

This study presents data on the growth rate and frequency of induction of the solid form of Ehrlich’s ascitic carcinoma (EAC) in mice in the short and long term after inoculation of ascitic cells irradiated ex vivo with a proton beam in the dose range of 30–150 Gy. It was shown that the growth rate of solid tumors after inoculation of irradiated cells ex vivo coincided with the growth of tumors in the control group. The frequency of tumor induction in mice after inoculation EAC cells irradiated at a dose of 30 Gy was 80%, 60 Gy – 60%, 90 Gy – 25%, 120 Gy – 10%, and with irradiation at a dose of 150 Gy, no tumors appeared during the entire observation period. Thus, we were able to determine the dose of proton radiation required to eliminate tumor cells and/or signaling factors that can lead to the induction of tumor growth of EAC in mice.
ENDOGENOUS BRASSINOSTEROIDS ARE INVOLVED IN THE FORMATION OF SALT RESISTANCE OF PLANTS
Authors: Kolomeichuk L. V. , Danilova E. D. , Murgan O. K. , Sauchuk A. L. , Litvinovskaya R. P. , Khripach V. А. , Kuznetsov V. V. , Efimova M. V. 
Published: April 2024

For the first time it was shown that potato plants responded to salt stress by changing the profile of endogenous brassinosteroids (BS). At the same time, a group of 6-keto-BS was identified, the content of which, unlike other analyzed groups of hormones, increased significantly during salinization. It was found that a 10-fold decrease in the level of endogenous BS in mutant Arabidopsis thaliana plants with impaired biosynthesis (det2) (or reception (bri1)) of phytosteroids leads to a decrease in their salt resistance, as evidenced by a decrease in the efficiency of photochemical processes of photosystem II (PSII) and inhibition of growth. The presented data confirm the idea of the involvement of endogenous BS in the formation of salt resistance of plants.
ANTIDIABETIC EFFECT OF A NEW ORIGINAL NT-3 DIPEPTIDE MIMETIC
Authors: Yagubova S. S. , Chernyshevskaya M. A. , Ostrovskaya R. U. , Gudasheva T. A. , Seredenin S. B. 
Published: April 2024

It was previously established that the original dipeptide mimetic of the 4th loop of NT-3, hexamethylenediamide bis-(N-monosuccinyl-L-asparaginyl-L-asparagine) (GTS-301), has a pronounced neuroprotective effect in vitro at concentrations of 10–5–10–12 М. In the present study, experiments on the streptozotocin-induced diabetes model in C57Bl/6 mice showed that GTS-301, administered intraperitoneally for 32 days at doses of 0.1 and 0.5 mg/kg, has antidiabetic activity manifested in the reduction of hyperglycemia, polydipsia, and in the increase of animal survival. The results obtained confirm the concept of the similarity of neurochemical mechanisms underlying the regulation of neurons and β-cells functions.
AGROECOLOGICAL ASSESSMENT OF HEAVY METALS AND ARSENIC CONTENT IN CHERNOZEM IN THE COMMON CENTRAL BLACK EARTH REGION OF RUSSIA
Authors: Lukin S. V. 
Published: April 2024

Agroecological assessment of the content of Mn, Zn, Ni, Cr, Cu, Pb, Co, As, Cd, Hg in the chernozems of common light-clay was carried out in the steppe zone of the Central Black Earth Region. As a result of studies, it was found that the content of the studied elements in virgin black soil was within the range of varying their concentrations in arable analogues or even lower. Only the gross content of Mn in virgin soil was above the upper limit of variation in the content of this element in arable soils. By average gross content in arable chernozems, common elements form the following descending series (mg/kg) Mn (397) Zn (42.9) Ni (33.1) Cr (23.7) Cu (15.8) Pb (11.2) Co (9.51) As (5.48) Cd (0.35) Hg (0.023), and in terms of the average content of mobile forms, the dependence is slightly different: Mn (4.14) Pb (0.75) Ni (0.59) Zn (0.36) Cr (0.31) Cu (0.1) Co (0.09) Cd (0.04) There was no excess of the established UEC and MAC standards for the studied elements in the studied soils, therefore there is no danger to obtain environmentally safe crop production. There was no excess of the established UEC and MAC standards for the studied elements in the studied soils, therefore there is no danger to obtain environmentally safe crop production. The content of mobile forms Mn, Zn, Cu, Co corresponds to a low level of availability, therefore, these elements must be introduced into agrocenoses with micro-fertilizers to increase the yield and quality of agricultural products.
INFLUENCE OF FULVIC ACID ON THE EGG LAYING OF QUEEN BEE IN THE SPRING PERIOD AND THE PRODUCTIVITY OF BEE FAMILY
Authors: Rumyantsev V. A. , Yaroshevich G. S. , Mazina G. S. , Mityukov A. S. , Puhalsky J. V. , Loskutov S. I. 
Published: April 2024

The paper analyzes the effect of a promising additive (BAA) fulvic acid on the reproductive function of queen bees and the productivity of bee layers. A single dose of carbohydrate supplementation (40% sucrase) was 200 ml per family. A total of 12 feedings were carried out with an interval of three days. The effect of the drug on the reproductive function of queen bees was determined by counting the number of printed brood using a grid frame every 12 days. As a result of the research, a positive effect of fulvic acid on the reproductive function of queen bees was established. When using fulvic acid as a spring feeding of bee colonies, a significant increase was established on average by 22.5% over two years of research, and the honey productivity of bee layers increased by 17.7%.
MONITORING OF LEAD CONTENT IN AGROECOSYSTEMS OF CENTRAL BLACK EARTH REGION OF RUSSIA
Authors: Lukin S. V. 
Published: April 2024

Studies on the environmental assessment of Pb content in agroecosystems were carried out in the forest-steppe zone of the Belgorod region, which is located in the south-west of the Central Black Earth region. The soil cover was represented mainly by leached chernozems. As a result of studies, it was established that in the layer of 0–20 cm of arable soils, the average gross content of Pb is 13.1, the concentration of mobile forms is 1.09 mg/kg, which does not exceed the background values and is significantly lower than the levels of APC and MAC. There were no significant differences in the content of Pb in the soil layers of 0–20 and 21–40 centimeters. The excess of background concentrations of this element is established in the soils of roadside ecosystems. The main source of Pb supply to the agroecosystems of the Belgorod region is organic fertilizers, but this does not pose a danger to soil pollution and crop production. The average Pb content of corn, barley and winter wheat grains did not differ significantly and was 0.267, 0.275, 0.292 mg/kg, respectively. Of the studied cultures, the minimum amount of this element was contained in soybean grains (0.155 mg/kg), and the maximum amount in sunflower seeds (0.335 mg/kg). Of perennial legumes, the minimum amount of Pb was contained in clover hay (0.185 mg/kg), and the maximum amount was esparceta (0.344 mg/kg). Exceeding the levels of the maximum permissible concentration and the maximum permissible level of Pb in crop production was not detected.
FIRST LA-ICP-MS APATITE FISSION-TRACK AGES FROM THE SIBERIAN PLATFORM BASEMENT (NEPSKO-BOTUOBINSKAYA ANTECLISE)
Authors: Bagdasaryan T. E. , Gayduk A. V. , Khubanov V. B. , Latyshev A. V. , Veselovskiy R. V. 
Published: April 2024

We present the first results of LA-ICP-MS apatite fission-track dating (AFT) from nine core samples from wells, that exposed the top of the crystalline basement of the Siberian platform within the Nepsko-Botuobinskaya anteclise on the ~2 km depth. Obtained AFT ages belong to three clusters with mean values of 200, 140, and 60 Ma. A thermal event of ~200 Ma is widespread throughout almost the entire Siberian platform and reflects the stage of its Early Jurassic uplift. Reset of the fission-track geochronometer in apatite ~140 Ma correlates with tectono-thermal event marking the final stage of the Mongol-Okhotsk fold belt collision. The youngest AFT ages of ~60 Ma, on the one hand, may reflect the early (crypto) stage of the Baikal rifting, and, on the other hand, be a consequence of the high content of uranium in apatite.
CARYOCHROITE IS A RARE MINERAL FROM THE GROUP OF TITANOSILICATES: CRYSTAL STRUCTURE, CRYSTAL CHEMISTRY AND THERMAL PROPERTIES
Authors: Soboleva S. V. , Boeva N. M. , Kartashov P. M. , Bortnikov N. S. 
Published: April 2024

The crystal structure of rare titanosilicate cariochroite was deternined using X-ray powder and srlected area diffraction data. The crystallochemical formula proposed – [Na(Sr0.5Ca0.5)Mg]3[Fe\(_{8}^{{3 + }}\)Mn(\({\text{Fe}}_{{0.5}}^{{2 + }}{\kern 1pt} {{\square }_{{{\text{0}}{\text{.5}}}}}\))]10(Ti2Si12)O37(OH)14(Н2О)3. Monoclinic unit cell parameters are: a 16.550(3), b 5.281(2), c 24.25(3) Å, β 93.0°, Z = 2, sp. gr. P2/n. The crystal structure represent the new type of complex Ti–Si–nrt, provided the big volune canals contaning some exchange cations, OH groups and water molecules.
ELEMENTAL SULFUR AND ITS ISOTOPIC COMPOSITION IN THE BLACK SEA WATER
Authors: Dubinin A. V. , Demidova T. P. , Semilova L. S. , Rimskaya-Korsakova M. N. , Dubinina E. O. , Kossova S. A. , Zologina E. N. 
Published: April 2024

As one of the main intermediate products of hydrogen sulfide oxidation, elemental sulfur plays an important indicator role in understanding the oxidative cycle of sulfur in the water of anoxic basins. The distribution of elemental sulfur in the Black Sea water column at stations located in the area of the continental slope is considered. For the first time, the concentration distributions of two forms of elemental sulfur depending on the depth in the Black Sea water were obtained: suspended elemental sulfur with a fraction of more than 0.45 μm (S0) and zero valency sulfur (ZVS), which includes the sum of elemental sulfur (suspended and colloidal) and polysulfide sulfur. In the upper anoxic waters, the concentration of S0 noticeably increases (almost 200 times relative to the 400 m depth) with an increase in the concentration of hydrogen sulfide and the density of water. At depths of more than 250 m, the concentration of both forms of sulfur remains almost constant (ZVS = 0.21 ± ± 0.03 µmol/kg, S0 = 0.05 ± 0.01 µmol/kg). A sharp increase in the concentration of S0 at the depths of 150–250 m is associated with the oxidation of hydrogen sulfide due to bacterial anoxygenic photosynthesis after sampling. The value of δ34S(ZVS) was determined in the waters of two stations Ash-26 and 149 at the depths of 450 and 600 m respectively, which turned out to be +2.2‰ higher than δ34S(Н2S) from the same depths, which indicates the bacterial origin of elemental sulfur.
INFLUENCE OF FULVIC ACID ON INCREASING LIFE AND PHYSIOLOGICAL STATE OF BEEES
Authors: Rumyantsev V. A. , Yaroshevich G. S. , Mazina G. S. , Mityukov A. S. , Puhalsky J. V. , Loskutov S. I. 
Published: April 2024

The article presents the results of research for (2020–2021). The results of the influence of different doses of fulvic acid on increasing the life span of bees kept in entomological cages and improving their physiological state are given. The studies were carried out in laboratory conditions at an air temperature of +27 ± 2°C, on bees of spring-summer generation. The experiment included three groups of bees in triplicate. The first group – control, in this group, the bees consumed 60% sucrose solution as top dressing. In the second group, the bees consumed a 60% sucrose solution, to which fulvic acid was added, at the rate of 0.1 ml per 200 ml of solution. The third group was fed a 60% sucrose solution, to which fulvic acid was added, at the rate of 0.2 ml per 200 ml of solution. According to the results of the research, it was found that fulvic acid at a dose of 0.1 ml per 200 ml of solution contributed to the prolongation of the life of bees. In this variant of the experiment, 30–40% death of bees occurred five, and 50% and 60% four days later than in the control. Fulvic acid, where an increased dose was used, did not have a significant effect on the lifespan of bees. As the bees aged, fulvic acid in both variants of the experiment reduced the load on the rectum and toxicity to the body, thereby improving their physiological state.
A NEW VARIETY OF CHLADNIITE FROM VOLCANIC EXHALATIONS. GENETIC CRYSTAL CHEMISTRY OF CHLADNIITE
Authors: Pekov I. V. , Zubkova N. V. , Agakhanov A. A. , Turchkova A. G. , Zhitova E. S. , Pushcharovsky D. Yu. 
Published: April 2024

A new, unusual Fe-free and As5+-enriched variety of chladniite, a rare phosphate of the fillowite group was found in exhalations of the active Arsenatnaya fumarole, Tolbachik volcano, Kamchatka, Russia. It belongs to the high-temperature (500–750°С) paragenesis with calciojohillerite, fluorapatite, metathénardite, diopside, enstatite, forsterite and hematite. This genetic type is novel for fillowite-group minerals. The crystal structure of Tolbachik chladniite is solved, R1 = 4.32%. It is trigonal, R–3, a = 14.9831(2), c = 42.8050(7) Å, V = 8322.1(3) Å3. The structural formula is: M13(Na0.56\(\square \)0.44)\(_{2}^{{M21}}\)(Na0.81Ca0.19)\(_{2}^{{M31}}\) (Na0.97\(\square \)0.03)\(_{6}^{{M12}}\)(Ca0.64Na0.36)\(_{6}^{{M1}}\)MnM2(Mg0.54Ca0.46)M3–9Mg\(_{{30}}^{{M10}}\)(Mg0.94Ca0.06)\(_{6}^{{M11}}\)Mg6(P33.53As2.47)O144 (Z = 3). The crystal chemical features of chladniite and their correlation with mode of occurrence are discussed for all chladniite findings known in meteorites and terrestrial objects of different genetic types.
FEATURES OF NITROGEN DEGASSING OF DHAJALA CHONDRITE (H3.8)
Authors: Voropaev S. А. , Dushenkо N. V. , Fedulov V. S. , Senin V. G. 
Published: April 2024

Samples of the Dhajala meteorite (ordinary chondrite, type H 3.8) were kept isothermically in a specially designed device in the temperature range from 300 to 800°C for 90 minutes. The composition and content of the released gases were studied on a gas chromatograph. The following were detected: CO, CO2, H2O in concentrations of 300–1000 μg/g of the sample; also H2, CH4 and H2S in concentrations of 0.1–40 μg/g. The total nitrogen content during degassing increased quasi-linearly over time from 40 to 500 μg/g at each fixed temperature. Based on experimental observations of the change in the rate of nitrogen release depending on temperature, it was concluded that the effect of phase transitions on the permeability of the mineral matrix.
Y-SHAPED FLUOROPHORES BASED ON <i>N</i>(2)-ARYL-1,2,3-TRIAZOLES: SYNTHESIS, THEORETICAL CALCULATIONS, OPTICAL PROPERTIES, AND APPLICATION OPPORTUNITIES FOR DETECTION OF NITROAROMATICS
Authors: Lavrinchenko I. A. , Moseev T. D. , Varaksin M. V. , Seleznev Y. A. , Sadieva L. K. , Zyryanov G. V. , Tsmokaluk A. N. , Charushin V. N. , Chupakhin O. N. 
Published: April 2024

A five-stage method for the synthesis of Y-shaped push-pull fluorophores based on 2-(4′-methoxyphenyl)-1,2,3-triazole has been described. These molecules proved to possess emission in the range from 350 to 450 nm and high quantum yields QY 90–99% in solvents of various polarity. An opportunity of using the obtained compounds as chemosensors for both aromatic and aliphatic nitroanalytes at concentrations from 300 ppb has been elucidated.
DISJOINING PRESSURE IN THIN SPHERICAL LIQUID FILMS AND VAPOR LAYERS WITH MOLECULAR CORRELATIONS INCLUDED
Authors: Shchekin A. K. , Gosteva L. A. 
Published: April 2024

Based on the expression for a grand thermodynamic potential as a molecular density functional, disjoining pressures in thin liquid films around nanosized wettable spherical particles and in thin vapor layers around nonwettable particles are calculated depending the degree of lyophilicity, film thickness and particle size. A characteristic feature of the approach is the full consideration of hard-sphere molecular correlations according to the fundamental measure theory in the density functional method and finding the complete dependence of the grand thermodynamic potential of the system on stable droplet or bubble size. Although the obtained results show a qualitative agreement between the new calculated disjoining pressure dependences and those obtained by us earlier in the framework of a simpler gradient method of the molecular density functional, the new results differ significantly quantitatively. It is confirmed that the disjoining pressure in the liquid film around nanosized lyophilic particle grows with the particle radius and lyophilicity.
CONSTRUCTIVE COMBINATORICS IN PRIMARY SCHOOL MATHEMATICS
Authors: Posicelskaya M. A. 
Published: April 2024

The paper is describing the class of educational problems from the course of mathematics and computer science for elementary school. This course has been implemented over the past decades by a team led by A.L. Semenov. In the problems it is required to find, build, list all objects that satisfy a certain system of conditions. The student conducts these activities in the visual world of the basic objects of discrete mathematics and computer science: strings (finite sequences of symbols), bags (multisets), tables, trees, and statements containing quantifiers. The connections of these problems with problems of computational combinatorics (“counting the number of options”), search problems of the theory of computational complexity, with “big ideas”, general cognitive strategies in their formation are considered. The content of education in our approach is more adequate to the context of the modern world.
РОЗВИТОК КООРДИНАЦІЙНИХ ЗДІБНОСТЕЙ КАРАТИСТІВ 8–10 РОКІВ НА ЕТАПІ ПОЧАТКОВОЇ ПІДГОТОВКИ
Authors: МИТРОФАНОВ Єгор , ПАШКОВ Ігор 
Published: April 2024

В статті досліджено цілеспрямоване використання засобів розвитку координаційних здібностей каратистів 8–10 років на етапі початкової підготовки, прояв яких є запорукою успіху на наступних етапах багаторічної підготовки. Мета дослідження – визначити вплив запропонованої методики розвитку координаційних здібностей юних каратистів 8–10 років, на етапі початкової підготовки на рівень підготовленості спортсменів. Аналіз отриманих результатів свідчить про те, що під впливом запропонованої методики розвитку координаційних здібностей на етапі початкової підготовки, показники фізичного розвитку кращі в експериментальній групі ніж в контрольній. Встановлені статистично значущі відмінності між контрольною та експериментальною групами за критерієм Стьюдента при p<0,05 у тестах: стрибки по координаційній дробині 5 м обличчям вперед t=4,49; стрибки по координаційній дробині 5 м спиною вперед t=2,99; стрибки на скакалці (оберти руками вперед) за 30 с t=4,23; спринт з різкою зміною напрямку руху t= 2,44; виконання 12 ударів руками та ногами по різних рівнях та в різних напрямках t=2,29; спринт з різкою зміною напрямку руху та виконання ударів по цілях t=2,96; 15 ударів уширо-ура-маваши t=2,05. Результати дослідження прояву координаційних здібностей юних каратистів 8–10 років, на етапі початкової підготовки можуть використовуватися фахівцями в галузі фізичної культури та спорту та дозволяють обрати оптимальні тренувальні навантаження, які сприятимуть ефективності управління тренувальним процесом і тим самим підвищити спортивну майстерність спортсменів.
Stabilisation measures on the de-occupied territories: conceptual interpretation, classification, and application features
Authors: Buhaichuk K. L. 
Published: April 2024

The publication provides a scientific analysis of the “stabilisation measures” concept which has recently been used to determine the specifics of public authorities and law enforcement agencies' activities on the de-occupied territories of our country. It has been proved that the concept of “stabilisation measures” arose in the course of NATO peacekeeping operations in the Balkans and is primarily associated with law enforcement activities of specially authorised military units capable of performing police functions. According to NATO’s Joint Doctrine (AJP-3.22), stabilisation measures are defined as special activities aimed at strengthening or providing temporary replacement for local police forces to help restore and/or maintain public order and security, the rule of law and the protection of human rights.
It is emphasised that the understanding of the content of stabilisation measures in national and foreign practice is different. Foreign researchers mainly associate stabilisation measures with law enforcement actions: ensuring public order and security, combating crime, protecting civilians, etc. In our country, a broader interpretation of the term has been formed, which, in addition to purely police measures, includes social, humanitarian, informational, and economic measures that cover the comprehensive restoration and development of the de-occupied territories.
It is proposed to divide stabilisation measures into general and special ones. The first type is related to the restoration of state power on the de-occupied territory, as well as to ensuring the vital activity of its civilian population. Special stabilisation measures are carried out to prevent sabotage and reconnaissance groups and illegal armed groups from entering the de-occupied territory and committing terrorist acts on infrastructure and communications facilities, ensuring public safety and order, preventing and suppressing crimes and other offences, eliminating the consequences of emergencies, and searching for persons who have committed crimes against the foundations of national security, war crimes and other offences during the occupation of the territory.
The number of conceptual provisions on the interpretation of the definition, purpose, principles, types and peculiarities of application of stabilisation measures in Ukraine have been formulated.