bluuebunny/crossref_metadata_2025_split huggingface dataset:
Untersuchungen zum Durchstanzverhalten von Stahlbetonfundamenten
Authors: Hegger Josef , Ricker Marcus , Ulke Bernd , Ziegler Martin 
Published: March 2006

AbstractDie nach verschiedenen internationalen Normen ermittelten Durchstanzwiderstände für Fundamente differieren zum Teil erheblich. Der Anteil der Bodenreaktionskraft, der von der einwirkenden Querkraft abgezogen werden darf, wird unterschiedlich festgelegt. Ziel der Untersuchungen war die Entwicklung eines konsistenten Bemessungsansatzes zum Durchstanzen von Fundamenten unter Berücksichtigung der Boden‐Bauwerk‐Interaktion. Fünf eigene Durchstanzversuche an Stahlbetonfundamenten auf realem Boden und nichtlineare Finite‐Elemente‐Simulationen bestätigen, daß die Versagensrisse deutlich steiler verlaufen als bei vergleichbaren Versuchen an Flachdecken und eine signifikante Abhängigkeit des Durchstanzwiderstands von der Schubschlankheit besteht. Basierend auf den so gewonnenen Erkenntnissen und einer Versuchsdatenbank wird ein empirischer Bemessungsansatz auf Grundlage der Durchstanzgleichung in DIN 1045‐1 entwickelt.
Vereinfachte, wirklichkeitsnahe Ermittlung der Durchbiegung von Stahlbetonträgern unter Kriechbeanspruchung
Authors: Bockhold Jörg , Pfister Tobias 
Published: March 2006

AbstractEs wird ein auf der Annahme der Affinität von Momenten‐ und Krümmungsfunktion basierendes Berechnungsverfahren zur vereinfachten, überschlägigen Abschätzung der Durchbiegung von Stahlbetonträgern unter Gebrauchslasten präsentiert. Der Einfluß der Kriechverformungen wird dabei wirklichkeitsnah erfaßt, so daß eine realistische Verformungsberechnung mit minimalem Berechnungsaufwand gelingt.
Die Abnahme von Tiefgaragen aus technischer Sicht
Authors: Schöppel Klaus 
Published: March 2006

AbstractDie Praxis zeigt, daß in Tiefgaragen infolge mangelhafter Planung und Ausführung ein erhebliches Schadenspotential vorliegt. Die Schäden infolge dieser Mängel treten augenscheinlich erkennbar erst nach einigen Jahren – meist nach Ablauf der Gewährleistung – auf. Daher ist eine sorgfältige Kontrolle bei der Abnahme von Tiefgaragen notwendig, um derartige Mängel frühzeitig feststellen zu können. Nachfolgend werden die Schäden in Tiefgaragen erläutert und darauf aufbauend die bei Abnahme zu kontrollierenden Problempunkte angeführt. Die Vorgehensweise bei der Abnahme von Tiefgaragen wird anhand dieser Problempunkte dargestellt. Diese Veröffentlichung basiert auf einem Vortrag am 9. Dingolfinger Baufachtag 2005.
Betontechnologie für das Absperrbauwerk der Talsperre Leibis/Lichte
Authors: Kühme Matthias , Burkert Wilfried , Schattschneider Herbert 
Published: March 2006

AbstractUngleich verteilte Wasserdargebote verlangen Überleitungssysteme. Für eine gesicherte Trinkwasserversorgung im Freistaat Thüringen wird dieser Forderung mit der Fertigstellung der Fernwasserversorgung aus dem Einzugsgebiet der Schwarza Rechnung getragen. Das Projekt dient im Endausbau der Gewährleistung einer stabilen und qualitätsgerechten Trinkwasserversorgung im Ostthüringer Raum.Das Versorgungssystem Schwarza verbindet die Flüsse Lichte (Vorsperre seit 1992 in Betrieb) und Katze (Beileitungsstollen) über den etwa 10 km langen Lichtestollen mit dem Wasserwerk Zeigerheim und einem weitverzweigten Fernleitungsnetz. Das Kernstück der Rohwassergewinnungsanlagen, die Talsperre Leibis/Lichte, komplettiert das System im Rahmen der zweiten Ausbaustufe. Mit dem Sperrenbau wurde im Herbst 2000 begonnen; im Herbst 2005 wurden die Betonierarbeiten beendet.
An Early “Atkins' Diet”: RA Fisher Analyses a Medical “Experiment”
Authors: Senn Stephen 
Published: March 2006

AbstractA study on vitamin absorption which RA Fisher analysed for WRG Atkins and co‐authored with him is critically examined. The historical background as well as correspondence between Atkins and Fisher is presented. (© 2006 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Assessing the extent of protein intermolecular interactions at air–water interfaces using spectroscopic techniques
Authors: de Jongh Harmen H. J. , Wierenga Peter A. 
Published: March 2006

AbstractThere is an ongoing debate about whether a protein surface film at an air–water interface can be regarded as a gelled layer. There is literature reporting that such films show macroscopic fracture behavior and a rheology comparable to three‐dimensional protein bulk‐networks. Ifthis is the case, a complete description of the formation of adsorbed layers should include a transition from single, freely moving proteins to a gelled layer. This report presents studies using spectroscopic techniques, such as infrared, fluorescence and neutron spectroscopy, or ellipsometry, to derive molecular insight in situ to substantiate the intermolecular networking in surface films of chicken egg ovalbumin. It is concluded that protein films, generated by equilibrium adsorption from the bulk, behave as a densely packed colloidal repulsive particle system, where the proteins still have a significant rotational mobility, have a predominantly retained globular fold, and show distinct (lateral) diffusion. Applied stresses on the surface film (by compressions of the interface) may result in protein denaturation and aggregation. This process renders a surface film from a colloidal particle into that of a gelled system. © 2006 Wiley Periodicals, Inc. Biopolymers 82: 384–389, 2006This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com
Functional phenotyping of human plasma using a 361‐fluorogenic substrate biosensing microarray
Authors: Gosalia Dhaval N. , Denney William S. , Salisbury Cleo M. , Ellman Jonathan A. , Diamond Scott L. 
Published: March 2006

AbstractA microarray presenting glycerol nanodroplets of fluorogenic peptide substrates was used as a biosensor for the detection of multiple enzyme activities within human plasma. Using 10 different plasma proteases (kallikrein, factor XIIa, factor XIa, factor IXa, factor VIIa, factor Xa, thrombin, activated protein C, uPA and plasmin) and a 361‐compound fluorogenic substrate library (Ac‐Ala‐P3‐P2‐Arg‐coumarin for P = all amino acids except Cys), a database was created for deconvoluting the relative activity of each individual enzyme signal in human plasma treated with various activators (calcium, kaolin, or uPA). Three separate deconvolution protocols were tested: searching for “optimal” sensing substrate sequences for a set of 5 enzymes and using these substrates to detect protease signals in plasma; ranking the “optimal” sensing substrates for 10 proteases using local error minimization, resulting in a set of substrates which were bundled via weighted averaging into a super‐pixel that had biosensing properties not obtainable by any individual fluorogenic substrate; and treating each 361‐element map measured for each plasma preparation as a weighted sum of the 10 maps obtained for the 10 purified enzymes using a global error minimization. The similarity of the results from these latter two protocols indicated that a small subset of <90 substrates contained the majority of biochemical information. The results were consistent with the state of the coagulation cascade expected when treated with the given activators. This method may allow development of future biosensors using minimal and non‐specific markers. These substrates can be applied to real‐time diagnostic biosensing of complex protease mixtures. © 2006 Wiley Periodicals, Inc.
Determination and pharmacokinetic study of bergenin in rat plasma by RP‐HPLC method
Authors: Shi Yan‐Bin , Shi Yan‐Ping , Meng Qing‐Gang 
Published: April 2006

AbstractA validated reversed‐phase high‐performance liquid chromatographic (RP‐HPLC) method was developed for the determination of bergenin in rat plasma. Bergenin in rat plasma was extracted with methanol, which also acted as a deproteinization agent. Chromatographic separation of bergenin was performed on a C18 column, with a mobile phase of methanol–water (22:78, v/v) at a flow‐rate of 0.8 mL/min and an operating temperature of 40°C, and UV detection was set at 220 nm. The calibration curve was linear over the range 0.25–50 µg/mL (r = 0.9990) in rat plasma. The limit of quantification was 0.25 µg/mL using a plasma sample of 100 µL. The extraction recoveries were 83.40 ± 6.02, 81.49 ± 2.40 and 72.51 ± 2.64% at concentrations of 0.5, 5 and 50 µg/mL, respectively. The intra‐day and inter‐day precision and accuracy were validated by relative standard deviation (RSD%) and relative error (RE%), which were in the ranges 3.74–9.91 and −1.6–8.0%. After intravenous administration to rats at the dose of 11.25 mg/kg, the plasma concentration–time curve of bergenin was best conformed to a two‐compartment open model. The main pharmacokinetic parameters indicated that bergenin exhibited a wide distribution and moderate elimination velocity in rat. Copyright © 2006 John Wiley & Sons, Ltd.
High‐performance liquid chromatographic method for the determination and pharmacokinetic study of wogonoside in rat serum after oral administration of traditional Chinese medicinal preparation Huang‐Lian‐Jie‐Du decoction
Authors: Deng Yuan‐Xiong , Lu Tong , Xie Lin , Liu Xiao‐Dong 
Published: April 2006

AbstractA high‐performance liquid chromatographic method for the determination of wogonoside in plasma of rats administrated orally with the traditional Chinese medicinal preparation Huang‐Lian‐Jie‐Du decoction was developed. Sample preparation was carried out by protein precipitation with a mixture of acetonitrile and methanol (1:1, v/v). The extracted sample was separated on a Hypersil C18 (150 × 5 mm i.d., 5 µm) analytical column by linear gradient elution using 0.05% (v/v) phosphoric acid (containing 5 mm sodium dihydrogen phosphate) and acetonitrile as mobile phase at a flow rate of 1.5 mL/min. The eluate was detected using a UV detector at 276 nm. The assay was linear over the range 0.109–7.0 µg/mL (R2 = 0.9999, n = 5). Mean recovery was determined as 98.39%. Intra‐ and inter‐day precisions (RSD) were ≤7.59%. The limit of quantitation was 0.109 µg/mL. After validation, the HPLC method developed was applied to investigate the preliminary pharmacokinetics of wogonoside in rat after oral administration of Huang‐Lian‐Jie‐Du decoction. Copyright © 2006 John Wiley & Sons, Ltd.
Atypical anastomosis of laryngeal nerves
Authors: Partab P. , Hurrinarain K. , Ramsaroop L. , Satyapal K.S. 
Published: March 2006

AbstractThe larynx and its associated structures derive their chief source of innervation from the superior and recurrent laryngeal nerves. Surgery of the larynx requires a sound knowledge of the normal anatomy as well as variations that may be encountered in this region. We report the presence of rare communications between the right external and internal laryngeal nerves as well as between the right external and inferior laryngeal nerves via a thyroid foramen. In addition, we report on bilateral innervation of the respective ipsilateral aryepiglottic, transverse, and oblique arytenoid muscles by the internal laryngeal nerve, which is contrary to the classical descriptions of this nerve. The anatomic features are described and clinical implications are highlighted. Clin. Anat. 19:651–656, 2006. © 2006 Wiley‐Liss, Inc.
Mondino de' Liuzzi and his Anothomia: A milestone in the development of modern anatomy
Authors: Crivellato Enrico , Ribatti Domenico 
Published: March 2006

AbstractMondino's Anothomia was written in Bologna around 1316. This book is the intellectual legacy of one of the fathers of human anatomy, and probably represents a collection of lessons given by the author at the Studium in Bologna. Mondino's Anothomia witnesses a profound renewal of the mode of understanding and teaching human anatomy through direct observation of dissected corpses. This book enjoyed an extraordinarily large dissemination in the whole of Europe, thanks to many extant manuscripts and printed editions. In this article, we present some selected passages from this remarkable book to let today's anatomists know how great was the descriptive skill of this medieval scientist, a pioneer in the anatomical discipline. Clin. Anat. 19:581–587, 2006. © 2006 Wiley‐Liss, Inc.
Proto‐professionalism and the dissecting laboratory
Authors: Slotnick Henry B. , Hilton Sean R. 
Published: March 2006

AbstractThis essay argues for medical students' dissection of cadavers because this activity offers medical students opportunities to have certain experiences and reflect on them in ways facilitating their development of mature medical professionalism at the time they enter clinical practice. Issues central to professionalism as we envision it are (1) cognitive abilities identified as reflective judgment and principled ethical reasoning as they are exercised in four practice domains and (2) learning to learn in medical settings. We argue further that a key feature of such setting is practitioners' having to deal with ill‐structured problems, and so we identify their features and relate their management to the sophisticated cognitive and learning abilities required of medical professionals. Clin. Anat. 19:429–436, 2006. © 2006 Wiley‐Liss, Inc.
The surgical anatomy of the ansa pectoralis
Authors: Loukas Marios , Louis Robert G. , Fitzsimmons John , Colborn Gene 
Published: March 2006

AbstractDetailed anatomical knowledge of the pectoral nerves is of clinical importance in surgeries as diverse as limb neurotization, mastectomy, orthopedic procedures and operations related to trauma. The brachial plexus of 200 cadavers were examined in an attempt to clarify the normal origins, courses and variations of the nerves with special emphasis on the ansa pectoralis (AP). In 75% the MPN arose from the anterior division of the inferior trunk of the brachial plexus and in 25% it arose from the medial cord. In 40% of specimens, the LPN arose from a single contributing nerve (anterior division of the superior trunk, 11%; anterior division of the middle trunk 18%; lateral cord, 11%). In the remaining 60% of specimens, the LPN arose from the fusion of two rootlets derived variably from the anterior divisions of the superior and middle trunks and the lateral cord. A single AP was found to be present bilaterally in 200 (100%) of the specimens. Classification of the AP was based upon its origin from the upper or lower rootlet of the LPN, the LPN itself, or from the deep branch of the LPN. AP‐1 (42%) arose from the deep branch of the LPN; AP‐2 (28%) arose directly from the LPN; AP‐3 (25%), arose from the lower rootlets of the LPN and rarely, the AP arose from the upper rootlet of the LPN and crossed posterior to the lower rootlet to communicate with the MPN (AP‐4, 5%). Irrespective of the aforementioned types, the AP was found to be present, crossing the second segment of the axillary artery in 90% of the specimens. These results could prove useful during the preoperative planning of neurotization and other surgical procedures involving the axilla. Clin. Anat. 19:685–693, 2006. © 2006 Wiley‐Liss, Inc.
Triceps brachii muscle demonstrating a fourth head
Authors: Tubbs R. Shane , Salter E. George , Oakes W. Jerry 
Published: March 2006

AbstractVariations of the triceps brachii muscle are apparently rare. We report an additional attachment site of the medial head of the triceps brachii found on the left side of a male cadaver. This head originated from the posterior aspect of the surgical neck of the humerus. Clinicians diagnosing or treating patients with weakness or pain of the posterior arm should consider anomalous muscles in this region that may result in neurovascular compression. Clin. Anat. 19:657–660, 2006. © 2006 Wiley‐Liss, Inc.
Directed Evolution of an Esterase from Pseudomonas fluorescens Yields a Mutant with Excellent Enantioselectivity and Activity for the Kinetic Resolution of a Chiral Building Block
Authors: Schmidt Marlen , Hasenpusch Daniel , Kähler Markus , Kirchner Ulrike , Wiggenhorn Kerstin , Langel Walter , Bornscheuer Uwe T. 
Published: March 2006

AbstractA triple mutant of an esterase from Pseudomonas fluorescens (PFE) that was created by directed evolution exhibited high enantioselectivity (E=89) in a kinetic resolution and yielded the building block (S)‐but‐3‐yn‐2‐ol. Surprisingly, a mutation close to the active site caused the formation of inclusion bodies, but remote mutations were found to be responsible for the high selectivity. Back mutations gave a variant (double mutant PFE Ile76Val/Val175Ala) that showed excellent selectivity (E=96) and activity (20 min for 50 % conversion, which corresponds to 1.25 U per mg of protein).
Transient renal failure due to hemolysis following transcatheter closure of a muscular VSD using an Amplatzer muscular VSD occluder
Authors: Spence Mark S. , Thomson John D. , Weber Naomi , Qureshi Shakeel A. 
Published: March 2006

AbstractTranscatheter closure of ventricular septal defects (VSDs) has become increasingly common. This case describes hemolysis causing renal failure and its spontaneous resolution following the transcatheter closure of a congenital muscular VSD using an Amplatzer muscular VSD occluder. © 2006 Wiley‐Liss, Inc.
Dissecting intramyocardial hematoma masquerading as a pseudoaneurysm of left ventricular free wall: An unusual case of myocardial rupture
Authors: Carcagnì Addolorata , Nusca Annunziata , Covino Elvio , Chello Massimo , D'Ambrosio Andrea , Patti Giuseppe , Di Sciascio Germano 
Published: March 2006

AbstractThis report presents a case of left ventricular intramyocardial dissection masquerading as a ventricular pseudoaneurysm. Only serial echocardiograms could lead to the correct diagnosis, and left ventricular angiography could appropriately direct further testing and treatment. © 2006 Wiley‐Liss, Inc.
A novel paclitaxel‐eluting porous carbon–carbon nanoparticle coated, nonpolymeric cobalt–chromium stent: Evaluation in a porcine model
Authors: Bhargava Balram , Reddy N. Krishna , Karthikeyan Ganesan , Raju Raghava , Mishra Sundeep , Singh Sandeep , Waksman Ron , Virmani Renu , Somaraju B. 
Published: March 2006

AbstractObjectives: We aimed to evaluate the response of porcine coronary arteries to a novel paclitaxel‐eluting porous carbon–carbon nanoparticle coated, nonpolymeric cobalt chromium stent. Background: Polymer based drug‐eluting stents significantly reduce restenosis. However, the indefinite presence of polymer is thought to initiate and sustain inflammation and contribute to the occurrence of late complications. Methods: Sixteen carbon–carbon coated, nonpolymeric cobalt chromium stents with two different doses of paclitaxel (eight of each) were implanted in porcine coronary arteries. In addition, eight cobalt chromium stents coated with a biodegradable polymer were also studied. Animals were sacrificed 6 weeks after stent implantation and histomorphometric analysis was performed. Results were compared among the three groups of stents. Results: The cobalt chromium stents coated with carbon–carbon with low and medium doses of paclitaxel both showed acceptable performance characteristics, with respect to endothelialization, neointimal hyperplasia, percentage diameter stenosis, inflammatory response, and tendency to fibrin deposition, when compared to historical data with the Cypher stent. On the other hand, the stents coated with poly(lactide) and poly(lactide‐co‐glycolide) biodegradable polymers and 0.7 μg/mm2 paclitaxel showed poor performance. There was a significant tendency to poor endothelialization, greater neointimal hyperplasia, percentage diameter stenosis, greater inflammatory response, and tendency to fibrin deposition (P < 0.01 for all parameters). Conclusions: This preclinical evaluation demonstrates the safety and efficacy of a novel cobalt chromium stent with a carbon–carbon coating and low and medium doses of paclitaxel. © 2006 Wiley‐Liss, Inc.
Stenting of the vertical vein in obstructed total anomalous pulmonary venous return as rescue procedure in a neonate
Authors: Lo‐A‐Njoe Shirley M. , Blom Nico A. , Bökenkamp Regina , Ottenkamp Jaap 
Published: March 2006

AbstractA newborn girl with progressive respiratory distress and cyanosis was found to have severely obstructed supracardiac total pulmonary venous return (TAPVR). Stenting of the stenosis provided immediate and effective relief of the obstruction until corrective surgery was performed. Catheter intervention should be considered in high‐risk infants with obstructed supracardiac TAPVR as part of the strategy for preoperative cardiovascular stabilization. © 2006 Wiley‐Liss, Inc.
A Variety of Spin‐Crossover Behaviors Depending on the Counter Anion: Two‐Dimensional Complexes Constructed by NH⋅⋅⋅Cl− Hydrogen Bonds, [FeIIH3LMe]Cl⋅X (X = PF6−, AsF6−, SbF6−, CF3SO3−; H3LMe = Tris[2‐{[(2‐methylimidazol‐4‐yl)methylidene]amino}ethyl]amine)
Authors: Yamada Masahiro , Hagiwara Hiroaki , Torigoe Haruna , Matsumoto Naohide , Kojima Masaaki , Dahan Françoise , Tuchagues Jean‐Pierre , Re Nazzareno , Iijima Seiichiro 
Published: March 2006

AbstractA family of spin‐crossover (SC) complexes, [FeIIH3LMe]Cl⋅X (X− = PF6−, AsF6−, SbF6−, CF3SO3−), 1–4, has been synthesized, in which H3LMe denotes the hexadentate N6 tripod‐like ligand tris[2‐{[(2‐methylimidazol‐4‐yl)methylidene]amino}ethyl]amine, containing three imidazole groups, with a view to establishing the effect of the counter anion on the SC behavior. These complexes have been found to crystallize in the same monoclinic crystal system with similar cell dimensions. The general crystal structure consists of a two‐dimensional (2D) extended network constructed by NH⋅⋅⋅Cl− hydrogen bonds between Cl− and the imidazole NH groups of three neighboring [FeIIH3LMe]2+ ions, while the anion X exists as an isolated counter anion and occupies the space between the 2D sheets. Magnetic susceptibilities and Mössbauer spectra have revealed a variety of SC behaviors depending on the counter anion, including a one‐step HS ⇄ (HS + LS)/2 (1, X = PF6−), a two‐step HS ⇄ (HS + LS)/2 ⇄ LS with a slow thermal relaxation (2, X = AsF6−), a gradual one‐step HS ⇄ LS (3, X = SbF6−), and a steep one‐step HS ⇄ LS with hysteresis (4, X = CF3SO3−). The complexes assume the space group P21/n in the HS state, P21 in the HS + LS state, and P21/n in the LS state. The FeN bond lengths and the N‐Fe‐N bond angles are indicative of the HS, HS + LS, and LS states. The molecular volumes, V, of the counter anions have been evaluated by quantum‐chemical calculations as follows: 53.4 Å3 (BF4−), 54.4 Å3 (ClO4−), 73.0 Å3 (PF6−), 78.5 Å3 (AsF6−), 88.7 Å3 (SbF6−), and 86.9 Å3 (CF3SO3−). The size and shape of the counter anion affects the flexible 2D network structure constructed by the hydrogen bonds, leading to modifications of the SC behavior. These estimated relative sizes of the counter anions correlate well with the observed SC behaviors.
Photochromic Reactions of Diarylethenes in Single Crystals with Intermolecular OH⋅⋅⋅N Hydrogen‐Bonding Networks
Authors: Morimoto Masakazu , Irie Masahiro 
Published: March 2006

AbstractThe crystal structures and photochromic performance of a single crystal of a diarylethene derivative possessing carboxyl groups, 1,2‐bis(5‐carboxyl‐2‐methyl‐3‐thienyl)perfluorocyclopentene (1 a), and cocrystals of 1 a with 4,4′‐, 2,4′‐, and 2,2′‐bipyridines were examined. In crystal 1 a, a discrete cyclic structure was observed, in which four 1 a molecules are linked through hydrogen bonds between the carboxyl groups. In the homocrystal, photoreactive and photoinactive conformers of 1 a exist in the ratio of 1:1. In the cocrystals of 1 a with bipyridines, OH⋅⋅⋅N‐type hydrogen bonds between 1 a and pyridyl groups were formed, and all 1 a molecules are fixed in a photoreactive conformation. Both the homocrystal 1 a and the cocrystals showed photochromic performances, and color variation from bluish‐violet to cyan was observed, depending on the conformation of the packed diarylethene molecules.