bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epilepsy‐related ambiguity in rating the child behavior checklist and the teacher's report form
Authors: Oostrom K.J. , Schouten A. , Kruitwagen C.L.J.J. , Peters A.C.B. , Jennekens‐Schinkel A. ,   for the Dutch Study Group of Epilepsy in Childhood (DuSECh)
Published: March 2024

ABSTRACT
Although the child behavior checklist (CBCL) and the teacher's report form (TRF) were not designed for diagnosing psychopathology in children with chronic illnesses, they have become extensively used research tools to assess behavioural problems in paediatric populations, including children with epilepsy. When applied to children with epilepsy, items like “staring blankly” or “twitching” can be rated on the basis of seizure features rather than behaviour and, hence, render behavioural scores ambiguous.
The aims were detection, and evaluation of the impact, of CBCL and TRF items eliciting ambiguity when applied to children with “epilepsy only” (idiopathic or cryptogenic epilepsy, attending normal schools).
Experts identified items that give rise to interpretational ambiguity of the ratings in epilepsy. By treating ratings on these items as missing values, their effect was evaluated in CBCL and TRF scores of 59 schoolchildren with “epilepsy only” and age and gender matched healthy classmates.
Seven items of the CBCL gave rise to ambiguity of which items 5 co‐occur on the TRF. Rescoring reduced psychopathology scores in children with “epilepsy only”, but not in those of healthy children: the percentage of patients trespassing the clinical cut off score, on at least one of the subscales, reduced from 46 to 23% on the CBCL and from 18 to 15% on the TRF.
Parents and teachers run the risk of confusing behaviour and seizure features when filling out the CBCL and TRF. In “epilepsy only”, prevalence estimates of psychopathology based on the CBCL and TRF, should be considered with some reserve.
Partial epilepsy with prominent auditory symptoms not linked to chromosome 10q
Authors: Bisulli Francesca , Tinuper Paolo , Marini Carla , Avoni Patrizia , Carraro Gianni , Nobile Carlo 
Published: March 2024

ABSTRACT
Autosomal dominant partial epilepsy with auditory features (ADPEAF) has been identified as a distinct genetic syndrome. Several families have been described linked to chromosome 10q24, which carries mutations in the LGI1 gene. We report a small new pedigree with partial epilepsy with auditory symptoms. We performed a detailed clinical study of the family, constructed an extended pedigree comprising 106 individuals, and obtained blood samples for genetic analysis. Individuals with seizures also underwent neurophysiological and neuroradiological investigations. Genetic analysis was performed with six microsatellite markers spanning to the critical region of chromosome 10q24. Mutation analysis of the coding sequence of LGI1 was performed in two patients. Five members of the family in generation IV had seizures. Three individuals had auditory auras, followed by generalised seizures in two and brief loss of contact in one, one had nocturnal tonic‐clonic seizures with an EEG suggestive of right temporal lobe onset, and one only had febrile seizures. In addition, a deceased woman was said to have had seizures. Haplotype analysis of this region of chromosome 10q24 failed to disclose a common haplotype in affected family members and no disease‐associated mutations were detected in the LGI1 gene, suggesting that this locus is not associated with the disease in our family. Our small sample with partial epilepsy with auditory symptoms, clinically resembles previously described ADPEAF families. However, the low number of patients is compatible with either autosomal dominant or other inheritance patterns. In the case of the former, the lack of segregation with 10q24 suggests that a second locus is involved in the aetiology of ADPEAF; in the latter, an epileptic syndrome also characterized by auditory features, but distinct from ADPEAF, could be transmitted in this family.
Life‐saving epilepsy surgery for status epilepticus caused by cortical dysplasia
Authors: Kršek Pavel , Tichý Michal , Belšan Tomás , Zámečník Josef , Paulas Lukáš , Faladová Ludvika , Jiruška Přemysl , Maulisová Alice , Komárek Vladimír 
Published: March 2024

ABSTRACT
A uniquely successful neurosurgical intervention in a four‐ month‐old child suffering from status epilepticus (SE) caused by focal cortical dysplasia is reported. Seizures appeared at postnatal day 10 and culminated as medically intractable focal motor SE three months later. The first MRI scan at postnatal week 2 was inconclusive; electroclinical features typical of malformations of cortical development led to the repetition of MRI at the age of 3 months that confirmed the correct diagnosis. Since all medical trials including thiopental anaesthesia have been unsuccessful in treatment of SE, urgent resection of the right frontal and parietal lobes was performed at 4 months of age. One month later, the child had become seizure‐free and her psychomotor development is proceeding well. Histopathological analysis of the resected brain tissue revealed abnormalities typical of the Taylor's type of focal cortical dysplasia. The aim of the report is to encourage considering surgery in selected patients suffering from medically intractable SE early in life.
Tolerability of tiagabine: a prospective open‐label study
Authors: Bauer Jürgen , Bergmann Arnfin , Reuber Markus , Stodieck Stefan Rudolf Günther , Genton Pierre 
Published: March 2024

ABSTRACT
Tiagabine was used as add‐on therapy in the treatment of epilepsy with partial and/or secondarily generalised seizures to evaluate tolerability and efficacy. Five hundred and seventy‐four patients (299 men and 275 women, mean age 38.1 years), with refractory partial seizures, were enrolled in this prospective, open‐label study. Tiagabine was added to one (44.1%) or more (up to nine) antiepileptic drugs. The median daily dose of tiagabine was 30 mg (mean 29.1, SD 12.0). The mean duration of follow‐up was 94.9 ± 42.7 days. 12.3% of patients were completely seizure‐free at the end of the observation period. Median total seizure frequency decreased from 4.5 to 2.0 seizures/4 weeks. Adverse events occurred in 78 patients (13.6%). Tiagabine proved to be a well‐tolerated AED.
Relationship between oscillations in the basal ganglia and synchronization of cortical activity
Authors: Cassim François , Labyt Etienne , Devos David , Defebvre Luc , Destée Alain , Derambure Philippe 
Published: March 2024

ABSTRACT
The functions of oscillations within the basal ganglia are poorly understood. We discuss in the present paper, the possible physiological or pathological roles of oscillatory activities within the basal ganglia, and their relationship to cortical oscillations. Three aspects are presented: 1. What do we know from animal studies? 2. What do we know from neurophysiological studies in parkinsonian patients? 3. What is the effect of L‐dopa treatment and electrical stimulation within basal ganglia circuits on cortical oscillations?
Animal studies suggest that neuronal oscillations are spontaneously generated within the basal ganglia system, especially from the GPE and the subthalamic nucleus (STN), but are mainly synchronized by cortical activity via the striatal inputs. Dopamine depletion results in a global increase of oscillations within the whole basal ganglia system, particularly in the GP‐NST network. Oscillations within the basal ganglia may, in part, be related to tremor since they are enhanced, especially in the globus pallidus internus (GPI) and the STN, in human and animal dopaminergic depletion. However, they also play a role in the physiology of movement as revealed by coherence analysis between cortex, muscles and GPI/STN in parkinsonian patients undergoing deep brain stimulation. It is known that the basal ganglia may influence cortico‐muscular oscillations such as the Piper rhythm and other rhythms in the beta band. In off‐drug parkinsonian patients, low frequency oscillations (4‐10 Hz) are favoured, presumably resulting in bradykinesia and low force. When medically (L‐dopa) or surgically (deep brain stimulation) treated, these low frequency oscillations are replaced by high frequency (70 Hz) oscillations that are important for motor programs to be correctly executed. Studies of cortical reactivity related to planning of voluntary movement in parkinsonian patients provide evidence that it is possible to influence cortical reactivity through the basal ganglia system.
The treatment of patients with hypothalamic hamartomas, epilepsy and behavioural abnormalities: facts and hypotheses
Authors: Palmini André , Paglioli‐Neto Eliseu , Montes Jose , Farmer Jean‐Paul 
Published: March 2024

ABSTRACTThe growing interest in the association between hypothalamic hamartomas (HH), epilepsy and behavioural abnormalities witnessed in recent years, has led to significant progress regarding the clinical presentations, pathophysiology and management of this entity. Patients with these lesions may occupy different points within a spectrum of severity of the epileptic and behavioural disorder, and may dynamically progress toward more malignant epilepsies with time. The role of the subcortical lesion in the generation of the gelastic seizures has been established, and encouraging results have been obtained with surgical resection, destruction or disconnection of the hamartoma. The present work highlights several aspects that should be taken into account for the selection of medical and surgical treatment for individual patients. We conclude with a reflection on what we still do not understand as regards in the genesis and surgical management of the neuropsychiatric disabilities related to this disorder.
Preliminary efficacy of levetiracetam in children
Authors: Glauser Tracy A. , Dulac Olivier 
Published: March 2024

ABSTRACT
Treatment of seizures in pediatric patients is complicated by the fact that the etiology of the disorder and the pharmacokinetics, efficacy, and safety of antiepileptic drugs (AEDs) may differ from that in adults. With few controlled clinical trials of AEDs in children, the selection of agents to treat pediatric patients must be made on the basis of information from small uncontrolled studies or the extrapolation of clinical trial results in adults. Data from a large number of children with a wide range of seizure disorders who were treated in small‐scale prospective studies, or whose records were retrospectively evaluated, indicate that levetiracetam reduces the frequency of seizures in pediatric patients. Available data also indicate that levetiracetam is well tolerated in pediatric patients, with a safety profile similar to that in adults, a low potential for behavioral disturbances, and no reported idiosyncratic adverse reactions. As with other AEDs, children metabolize and clear levetiracetam more rapidly than adults, and somewhat higher doses (based on body weight) are needed to achieve desired plasma concentrations. Several ongoing studies will provide further information on the pharmacokinetics, efficacy, and safety of levetiracetam in this patient population.
Neuroimaging of focal cortical dysplasia: neuropathological correlations
Authors: Colombo Nadia , Citterio Alberto , Galli Carlo , Tassi Laura , Russo Giorgio Lo , Scialfa G. , Spreafico Roberto 
Published: March 2024

ABSTRACT
Focal cortical dysplasia is a well‐known cause of intractable epilepsy with early onset of seizures, and is potentially amenable to surgical therapy.
It was first described by Taylor in 1971 as a peculiar malformative disorganisation of the neocortex characterised at histology by loss of cortical lamination and accompanied by giant, dysmorphic neurones and, most frequently, by ‘balloon cells’ littered throughout the cortex and sub‐cortical white matter. While in the past decades the term ‘cortical dysplasia’ has referred to various malformations of cortical development, such as agyria, pachygyria, polymicrogyria, heterotopia and hemimegalencephaly, it is now widely accepted that the entity identified by Taylor should be considered separately, from both histological and neuroimaging standpoints. More recently, the recognition of various histological subtypes of focal cortical dysplasia characterised by different degrees of cortical disruption with or without cytological abnormalities has generated several classifications that are still unsatisfactory. With better magnetic resonance capability, subtle and very small focal cortical dysplasias may now be visualised and the differential magnetic resonance aspects of the histological subgroups can be established. We will discuss the problem of histopathological classification and magnetic resonance imaging differentiation of the various subtypes of focal cortical dysplasia in the light of personal data collected from a large series of epileptic patients who underwent surgery and had a histological diagnosis of focal cortical dysplasia.
Factors underlying scalp‐EEG interictal epileptiform discharges in intractable frontal lobe epilepsy
Authors: Vadlamudi Lata , So Elson L. , Worrell Gregory A. , Mosewich Russell K. , Cascino Gregory D. , Meyer Fredric B. , Lesnick Timothy G. 
Published: March 2024

ABSTRACT

Aims
Scalp‐EEG interictal epileptiform discharges (IEDs) may be less predictive of the outcome of frontal lobe epilepsy surgery than of temporal lobe epilepsy surgery. We identified factors associated with the location of scalp‐EEG IEDs in intractable frontal lobe epilepsy.

Methods
Ten factors were assessed in a retrospective review of 53 patients with either concordant (frontal lobe seizure focus) or discordant (generalized or outside frontal seizure focus) IED or both, who had excellent surgical outcomes. The Fisher exact test and the Wilcoxon rank sum test determined statistically significant associations.

Results

Thirty‐six patients (68%) had concordant IED, 24 (45%) discordant IED, and 17 (32%) both. Younger age at onset was significantly associated with discordant IED (mean, 7.5 years
versus
17 years for patients without discordant IED;
P
< 0.01), whereas duration of epilepsy was not. Seizure foci at the frontal convexity were associated with concordant IED. About 72% of patients with a convexity seizure focus had concordant IED, compared with only 33% of patients with mesial frontal foci having concordant IED (
P
= 0.06).

Conclusions
Early seizure onset in intractable frontal lobe epilepsy is associated with IEDs discordant with seizure focus. Frontal convexity seizure foci are more likely than mesial frontal seizure foci to be associated with concordant discharges.
Late onset hyperekplexia
Authors: Hamelin Sophie , Rohr Pascale , Kahane Philippe , Minotti Lorella , Vercueil Laurent 
Published: March 2024

ABSTRACT
We report on the case of an 86‐year‐old woman who rapidly became unable to stand and walk because of jerky movements, suggesting a clinical diagnosis of myoclonus. It was observed that both unexpected and expected stimuli (audiogenic, tactile, or visual) triggered the myoclonic jerks. Electrophysiological exploration, including a coupled EEG‐EMG study, showed the occurrence of a patterned motor response to each stimulation (whatever the modality), consisting of eye blinking, head flexion, abduction of the upper arms, movement of the trunk, and bending of the knees. Given the absence of any relevant past history and lack of biological or neurological abnormalities including on CT scan brain imaging, the diagnosis of late‐onset hyperekplexia was suggested. Substantial abatement of the clinical symptomatology was obtained after introduction of low‐dose clonazepam. [published with videosequences]
Canaux ioniques et épilepsies
Authors: Mazzuca Michel , Lesage Florian , Lazdunski Michel 
Published: March 2024

RÉSUMÉ
Les canaux ioniques sont à l'origine de la génération et de la modulation de l'excitabilité neuronale. Les crises épileptiques sont la manifestation d'une activité électrique anormale liée à un défaut dans le contrôle de cette excitabilité. Au cours des dix dernières, des mutations génétiques dans une douzaine de canaux ioniques, récepteurs canaux et transporteur ionique ont été associées à différentes formes d'épilepsies idiopathiques. Cet article passe en revue les différents syndromes épileptiques héréditaires impliqués, les mutations associées et leurs effets fonctionnels sur les canaux. Bien que les corrélations entre phénotypes et génotypes soient encore difficiles à établir, les résultats obtenus suggèrent de nouvelles pistes pour le développement de traitements antiépileptiques plus ciblés.
Épilepsies et retard mental : les syndromes génétiques
Authors: Livet Marie‐Odile , Villeneuve Nathalie , Daquin Géraldine , Cournelle Marie‐Anne , Mancini Joselle , Moncla Anne 
Published: March 2024

RÉSUMÉ
La recherche de l'étiologie d'une déficience mentale chez les enfants et les adultes est fondamentale et nécessite une approche clinique rigoureuse ainsi qu'une collaboration étroite entre les différents spécialistes. Certains syndromes génétiques avec une déficience intellectuelle peuvent être associés avec des dysmorphies, des comportements particuliers, ainsi que des syndromes épileptiques cliniquement repérables. L'identification de ces syndromes épileptiques spécifiques peut être un indice important, conduisant au diagnostic de ces syndromes génétiques. Par ailleurs, ces régions chromosomiques dont les aberrations sont associées de façon significative avec des crises peuvent être des cibles privilégiées pour la recherche des gènes impliqués dans l'épilepsie. Les principaux syndromes génétiques comportant une épilepsie caractéristique sont brièvement décrits : syndrome d'Angelman, duplication de la région 15q11‐q13, syndrome de Wolf‐Hirschorn, syndrome du chromosome 20 en anneau, syndrome de l'X fragile.
Epilepsie et maladies neurodégénératives de l'adulte
Authors: Vercueil Laurent 
Published: March 2024

RÉSUMÉ
La pathologie neurodégénérative va devenir potentiellement dans les années à venir la première cause d'épilepsie du sujet adulte, en raison du vieillissement de la population occidentale. Curieusement, elle reste, comme cause d'épilepsie, très peu étudiée, tant dans ses aspects épidémiologiques, diagnostiques que thérapeutiques. Dans la maladie d'Alzheimer, environ 10 % de sujet présentent une épilepsie, nécessitant souvent le recours aux traitements antiépileptiques. Ce travail présente une revue de la littérature consacrée à ce sujet, et discute des principes thérapeutiques dans ce contexte.
Can we predict refractory epilepsy at the time of diagnosis?
Authors: Semah Franck , Ryvlin Philippe 
Published: March 2024

ABSTRACT
The early prediction of intractability is a major challenge in epileptology. Some prognostic factors have been pointed out, most of which simply underlined that partial epilepsy is more difficult to control than idiopathic generalized epilepsy (IGE). Indeed, the main predictors are the presence of a brain lesion demonstrated by neuroimaging or suggested by a neurological deficit or a developmental delay, as well as electroclinical evidence of non idiopathic partial epilepsy. Little is known about the relationship between the location of the epileptogenic area and the chance of being seizure‐free in patients with partial epilepsy. Some data suggest that temporal lobe epilepsy (TLE) is more difficult to control than other partial epilepsies, but this might only reflect the prognostic impact of hippocampal sclerosis. Indeed, several studies have shown that the majority of patients with MRI evidence of hippocampal sclerosis develop refractory epilepsy. This observation also applies to patients with malformation of cortical development (MCD). The response to the first AED is another early predictor of refractory epilepsy. At the time of diagnosis, several prognostic factors are available to predict drug resistance, but further studies are still needed to better delineate the specific role of each of these factors, and to offer a more accurate prediction of long term seizure outcome.
The consequences of idiopathic partial epilepsies in relation to neuropsychological functioning: a closer look at the associated mathematical disability
Authors: Sart Z. Hande , Demirbilek Veysi , Korkmaz Barış , Slade Peter D. , Dervent Ayşın , Townes Brenda D. 
Published: March 2024

ABSTRACT
Although the seizure prognosis is mostly favorable in idiopathic partial epilepsies, there is some empirical evidence showing that subtle neuropsychological impairments, with a consequent risk of academic underachievement, are not rare. We investigated neuropsychological functioning including attention, memory, visuomotor ability, and executive functioning with a closer look at the associated mathematical ability in patients with idiopathic partial epilepsies. A battery of age‐appropriate, neuropsychological and mathematics achievement tests was administered to 30 participants with idiopathic partial epilepsy [13 children with benign epilepsy with centrotemporal spikes (BECTS), 17 children with idiopathic childhood occipital epilepsies (ICOE)], and to 30 healthy participants matched for age, sex, handedness, and socioeconomic status. Results did not support any impairment in overall neuropsychological functioning in participants with idiopathic partial epilepsies, whereas, isolated deficits did exist. The mean performance of the IPE group was significantly lower than the control group in six out of 12, neuropsychological measures: drawing (p < 0.01), digit span (p < 0.05), verbal learning (p < 0.01), object assembly (p < 0.01), similarities (p < 0.05), and vocabulary (p < 0.001). Results suggested that one should be cautious regarding neuropsychological and academic prognosis in the so‐called benign idiopathic partial epilepsies of childhood.
Seizures, epilepsy and vascular disorders
Authors: Rumbach Lucien 
Published: March 2024

ABSTRACT
Stroke is a major cause of seizures in the elderly. About 10% of all stroke patients experience one or several seizures; they may occur during the first 24 hours after the stroke, in the early and late stages and after several months or even years following the initial vascular accident. We review current data on epidemiology, risk factors, semiology, differential diagnosis, follow‐up and recurrence, and management of seizures following stroke.
Experiences of physical education teachers in District of Dinalupihan on students' performance assessment in times of covid-19 pandemic
Authors: Sinag Jay Mark Dela Pena 
Published: March 2024

The global COVID-19 pandemic has brought modifications to the world’s education system and not only in the Philippines and requires us to adapt to the change in the teaching-learning process which both teachers and students has to face for the quality education of the country. The radical shift to digital pedagogy followed by online assessments and examinations brought new experiences to both educators and learners like using different technological softwares. This study utilized a qualitative-phenomenological research approach that seeks to understand and describe the universal essence of a phenomenon. The approach investigates the everyday experiences of human beings while suspending the researchers’ preconceived assumptions about the phenomenon (Alchemer, 2021). This study was participated by the Physical Education Teachers from the Department of Education who experienced the new modalities of delivering the subject. The objectives of this study is to identify the problems that physical education teachers face while assessing students' performance, coping methods do physical education teachers use to deal with the challenges, and to look for intervention strategy can be suggested based on the study's findings? Two (2) themes were developed and 8 subthemes were revealed as a result of the data analysis. The themes revealed the most of experiences of the teachers on the assessment of students’ performance and how they respond to the challenges. As a result of these findings, the researchers created an Intervention Program to assist them in developing and improving their knowledge, skills, talents, conduct and teaching competencies to address the issues.