bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gonadal Function in Males After Chemotherapy for Early-Stage Hodgkin's Lymphoma Treated in Four Subsequent Trials by the European Organisation for Research and Treatment of Cancer: EORTC Lymphoma Group and the Groupe d'Étude des Lymphomes de l'Adulte
Authors: van der Kaaij Marleen A.E. , Heutte Natacha , Le Stang Nolwenn , Raemaekers John M.M. , Simons Arnold H.M. , Carde Patrice , Noordijk Evert M. , Fermé Christophe , Thomas José , Eghbali Houchingue , Kluin-Nelemans Hanneke C. , Henry-Amar Michel 
Published: May 2007

Purpose To analyze fertility in male patients treated with various combinations of radiotherapy and chemotherapy, with or without alkylating agents, or with radiotherapy alone for Hodgkin's lymphoma. Patients and Methods Follicle-stimulating hormone (FSH) levels were measured in patients with early-stage upper-diaphragmatic disease enrolled in four European Organisation for Research and Treatment of Cancer (EORTC) trials (H6-H9). Median follow-up after therapy was 32 months. Patients with FSH measurement at least 12 months after end of treatment (n = 355) were selected to assess post-treatment fertility. Patients with FSH measurement 0 to 9 months after therapy (n = 349) were selected to analyze fertility recovery; of these, patients with elevated FSH (> 10 U/L; n = 101) were followed until recovery. Factors predictive for therapy-related infertility were assessed by logistic regression. Results The proportion of elevated FSH was 3% and 8% in patients treated with radiotherapy only or with nonalkylating chemotherapy (doxorubicin, bleomycin, vinblastine, dacarbazine [ABVD], epirubicin, bleomycin, vinblastine, prednisone [EBVP]); it was 60% (P < .001) after chemotherapy containing alkylating agents (mechlorethamine, vincristine, procarbazine, prednisone [MOPP], MOPP/doxorubicin, bleomycin, vinblastine [ABV], bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, prednisone [BEACOPP]). After a median time of 19 months, recovery of fertility occurred in 82% of patients treated without alkylating chemotherapy. This proportion was 30%, statistically (P < .001) lower in those treated with alkylating chemotherapy, and median time to recovery was 27 months. The post-treatment proportion of elevated FSH increased significantly (P < .001) with the dose of alkylating chemotherapy administered, and recovery was less frequent and slower after higher doses. Age more than 50 years and stage II disease also contributed to poor outcome. Conclusion Fertility can be secured after nonalkylating chemotherapy for Hodgkin's lymphoma. In contrast, alkylating chemotherapy has a dismal effect, even after a limited number of cycles.
Poor Outcome of Hormone Receptor–Positive Breast Cancer at Very Young Age Is Due to Tamoxifen Resistance: Nationwide Survival Data in Korea—A Report From the Korean Breast Cancer Society
Authors: Ahn Sei Hyun , Son Byung Ho , Kim Seok Won , Kim Seung Il , Jeong Joon , Ko Seung-Sang , Han Wonshik 
Published: May 2007

PurposeBreast cancer in very young women (age < 35 years) is uncommon and poorly understood. We sought to evaluate the prognosis and treatment response of these patients compared with women ages 35 to 50 years.Patients and MethodsWe analyzed data from 9,885 breast cancer patients age ≤ 50 years who were part of the Korean Breast Cancer Society registration program between 1992 and 2001. The overall survival (OS) and breast cancer-specific survival (BCSS) were compared between age groups.ResultsOne thousand four hundred forty-four patients (14.6%) were younger than age 35 and 8,441 (85.4%) patients were between 35 and 50 years of age. Younger patients had significantly higher T-stage and higher lymph node positivity and lower hormone receptor expression than older patients. Younger patients had a greater probability of death than older patients, regardless of tumor size or lymph node status. The survival difference was significant for patients with positive or unknown hormone receptor status (P < .0001), but not for patients with negative hormone receptor status. In a multivariate analysis, the interaction term of young age and hormone receptor positivity was significant for OS and BCSS with a hazard ratio for OS of 2.13 (95% CI, 1.52 to 2.98). The significant survival benefit from adjuvant hormone therapy after chemotherapy observed in older patients (hazard ratio for OS, 0.61; 95% CI, 0.47 to 0.79; P = .001) could not be seen in younger patients (P > .05).ConclusionYounger patients (age < 35) showed worse prognosis than older patients (age, 35 to 50 years) only in the hormone receptor–unknown or hormone receptor–positive subgroups. Adjuvant tamoxifen therapy might provide less survival benefit when added to chemotherapy in very young breast cancer patients.
American Society of Clinical Oncology 2007 Clinical Practice Guideline Update on the Role of Bisphosphonates in Multiple Myeloma
Authors: Kyle Robert A. , Yee Gary C. , Somerfield Mark R. , Flynn Patrick J. , Halabi Susan , Jagannath Sundar , Orlowski Robert Z. , Roodman David G. , Twilde Patricia , Anderson Kenneth 
Published: May 2007

Purpose To update the recommendations for the use of bisphosphonates in the prevention and treatment of bone disease in multiple myeloma. The Update Committee expanded the guideline to include a discussion of osteonecrosis of the jaw (ONJ). Methods For the 2007 update, an Update Committee composed of members from the full panel completed a review and analysis of data published since 2002. Searches of Medline and the Cochrane Collaboration Library databases were performed. Recommendations For multiple myeloma patients who have, on plain radiograph(s) or imaging studies, lytic destruction of bone or spine compression fracture from osteopenia, intravenous pamidronate 90 mg delivered over at least 2 hours or zoledronic acid 4 mg delivered over at least 15 minutes every 3 to 4 weeks is recommended. Clodronate is an alternative bisphosphonate approved worldwide, except in the United States, for oral or intravenous administration. New dosing guidelines for patients with pre-existing renal impairment were added to the zoledronic acid package insert. Although no similar dosing guidelines are available for pamidronate, the Update Committee recommends that clinicians consider reducing the initial pamidronate dose in patients with pre-existing renal impairment. Zoledronic acid has not been studied in patients with severe renal impairment and is not recommended in this setting. The Update Committee suggests that bisphosphonate treatment continue for a period of 2 years. At 2 years, physicians should seriously consider discontinuing bisphosphonates in patients with responsive or stable disease, but further use is at the discretion of the treating physician. The Update Committee also discusses measures regarding ONJ.
Germline CDKN1B/p27Kip1 Mutation in Multiple Endocrine Neoplasia
Authors: Georgitsi Marianthi , Raitila Anniina , Karhu Auli , van der Luijt Rob B. , Aalfs Cora M. , Sane Timo , Vierimaa Outi , Mäkinen Markus J. , Tuppurainen Karoliina , Paschke Ralph , Gimm Oliver , Koch Christian A. , Gündogdu Sadi , Lucassen Anneke , Tischkowitz Marc , Izatt Louise , Aylwin Simon , Bano Gul , Hodgson Shirley , De Menis Ernesto , Launonen Virpi , Vahteristo Pia , Aaltonen Lauri A. 
Published: May 2007

Abstract
Context: Germline mutations in the MEN1 gene predispose to multiple endocrine neoplasia type 1 (MEN1) syndrome, but in up to 20–25% of clinical MEN1 cases, no MEN1 mutations can be found. Recently, a germline mutation in the CDKN1B gene, encoding p27Kip1, was reported in one suspected MEN1 family with two acromegalic patients.
Objective: Our objective was to evaluate the role of CDKN1B/p27Kip1 in human tumor predisposition in patients clinically suspected of MEN1 but testing negative for MEN1 germline mutation as well as in familial and sporadic acromegaly/pituitary adenoma patients.
Design: Genomic DNA was analyzed for germline mutations in the CDKN1B/p27Kip1 gene by PCR amplification and direct sequencing.
Setting: The study was conducted at nonprofit academic research and medical centers.
Patients: Thirty-six Dutch and one German suspected MEN1 patient, who previously tested negative for germline MEN1 gene mutations, were analyzed. In addition, 19 familial and 50 sporadic acromegaly/pituitary adenoma patients from Europe and the United States were included in the study.
Main Outcome Measures: We analyzed germline CDKN1B/p27Kip1 mutations in individuals with pituitary adenoma and MEN1-like features.
Results: A heterozygous 19-bp duplication (c.59_77dup19) leading to a truncated protein product was identified in one Dutch patient with suspected MEN1 phenotype, pituitary adenoma, carcinoid tumor, and hyperparathyroidism (one of 36, 2.8%). No mutations were detected in either familial or sporadic acromegaly/pituitary adenoma patients.
Conclusions: Our results support the previous finding that germline CDKN1B/p27Kip1 mutations predispose to a human MEN1-like condition. However, such mutations appear uncommon in suspected MEN1 cases and rare or nonexistent in familial or sporadic acromegaly/pituitary adenoma patients.
Transport characteristics of zolmitriptan in a human intestinal epithelial cell line Caco-2
Authors: Yu Lushan , Zeng Su 
Published: May 2007

AbstractThe intestinal absorption characteristics and the efflux mechanisms of zolmitriptan, a new generation and highly selective 5-HT1B/1D receptor agonist used in the acute oral treatment of migraine, were investigated. A human intestinal cell line, Caco-2, was used as an in-vitro model of the intestinal mucosa to assess transepithelial transport of zolmitriptan. In the Caco-2 cells, the absorptive transport of zolmitriptan was pH dependent and the transport was enhanced at weakly alkali pH on the apical side. No concentration dependence and saturation were observed for the apical-to-basolateral and basolateral-to-apical transport of zolmitriptan at a concentration of 0.1–10 mM. The permeability ratio value was about 1.5-2.6 at a concentration of 0.1–2.0 mM. Inhibition experiments using verapamil, nifedipine and nimodipine as inhibitors were studied and indicated that P-glycoprotein participated in the transport of zolmitriptan. Inhibition of the Na+-H+ exchanger with amiloride resulted in a significant increase in absorption and a slight inhibition in secretion. This suggests that the Na+-H+ exchanger may be involved in the transport of zolmitriptan. The results indicated that the transport of zolmitriptan was mediated by both passive diffusion and active transport. A series of drug-drug interaction experiments were carried out between zolmitriptan and some drugs that may be co-administrated with zolmitriptan in the clinic. The results indicated that flunarizine, cetirizine, propranolol and atenolol potently decreased both the apical-to-basolateral and basolateral-to-apical transport rate of zolmitriptan. Cimetidine and aspirin slightly inhibited the apical-to-basolateral transport of zolmitriptan, but significantly decreased the basolateral-to-apical transport of zolmitriptan. Thus, the absorption drug-drug interactions should be considered when these drugs are co-administrated with zolmitriptan in the clinic.
Topical anti-inflammatory activity of extracts and compounds from Hypericum perforatum L.
Authors: Sosa Silvio , Pace Roberto , Bornanciny Anna , Morazzoni Paolo , Riva Antonella , Tubaro Aurelia , Loggia Roberto Della 
Published: May 2007

Abstract
Three preparations of Hypericum perforatum L. (a hydroalcoholic extract, a lipophilic extract and an ethylacetic fraction) and the pure compounds hypericin, adhyperforin, amentoflavone, hyperoside, isoquercitrin, hyperforin dicyclohexylammonium (DHCA) salt and dicyclohexylamine were evaluated for their topical anti-inflammatory activity. H. perforatum preparations provoked a dose-dependent reduction of Croton-oil-induced ear oedema in mice, showing the following rank order of activity: lipophilic extract &gt; ethylacetic fraction &gt; hydroalcoholic extract (ID50 (dose that inhibited oedema by 50%) 220, 267 and &gt;1000 μg cm−2, respectively). Amentoflavone (ID50 0.16μmol cm−2), hypericin (ID50 0.25μmol cm−2), hyperforin DHCA salt (ID50 0.25μmol cm−2) and adhyperofrin (ID50 0.30μmol cm−2) had anti-inflammatory activity that was more potent or comparable to that of indometacin (ID50 0.26 μmol cm−2), whereas isoquercitrin and hyperoside were less active (ID50 about 1μmol cm−2). As dicyclohexylamine alone was inactive, the effect of hyperforin DHCA salt can be attributed completely to the phloroglucinol moiety. The pharmacological activity and phytochemical profile of the tested extracts and fraction suggest that different constituents are involved in the topical antiphlogistic property of H. perforatum in-vivo.
Red wine polyphenolic compounds inhibit tracheal smooth muscle contraction during allergen-induced hyperreactivity of the airways
Authors: Franova Sona , Nosalova Gabriela , Pechanova Olga , Sutovska Martina 
Published: May 2007

AbstractThe aims of the study were to investigate the short and long-term effects of Provinol (red wine polyphenolic compounds) on tracheal smooth muscle reactivity using an in-vitro model of ovalbumin-induced airway inflammation in guinea-pig trachea, and to evaluate the role of nitric oxide (NO) in the bronchodilatory effect of Provinol.The amplitude of tracheal smooth muscle contraction in response to mediators of bronchoconstriction —histamine (10 nM-1 mM), acetylcholine (10 nM-1 mM) and to allergen (ovalbumin 10−5-10−3 g mL−1) was used as a parameter of tracheal smooth muscle reactivity. To test the short-term effects of Provinol, isolated tracheal strips were pre-treated for 30 min with Provinol (10−4mg mL−1) alone or in combination with Nω-nitro-L-arginine methyl ester (L-NAME; 10−6mol L−1). To test the long-term effects of Provinol, isolated tracheal strips were prepared from guinea pigs that had been treated for 14 days with Provinol (20mg kg−1 per day) alone or in combination with L-NAME (40 mg kg−1 per day).Incubation of tracheal smooth muscle with Provinol decreased the amplitude of contraction in response to ovalbumin, histamine and acetylcholine. The non-selective NO synthase inhibitor L-NAME partially abolished the effect of Provinol on acetylcholine and ovalbumin-induced but not histamine-induced bronchoconstriction. A similar profile was observed after 14 days' oral administration of Provinol.In conclusion, Provinol inhibited the allergen- and spasmogen-induced contraction of tracheal smooth muscle in ovalbumin-sensitized guinea pigs via a mechanism that was mediated at least partially through the metabolism of NO.
Are we missing mumps epididymo-orchitis?
Authors: Emerson C , Dinsmore W W , Quah S P 
Published: May 2007

Mumps epididymo-orchitis has not been recorded as a cause of testicular symptoms without systemic features (including parotitis). The aim of the present study was to assess if we were missing cases in the genitourinary clinic during a previous outbreak of mumps in the community. During a prospective pilot study from November 2005 to February 2006, all patients presenting with symptoms or signs of epididymo-orchitis were studied. These patients were assessed for previous exposure to mumps virus or vaccine, and any current evidence of systemic illness. All patients included had a full sexual health screen (loop test, chlamydia polymerase chain reaction [PCR], gonorrhoea culture, HIV and Venereal Disease Research Laboratory [test]/ Treponema pallidum particle agglutination assay), urinary tract infection excluded by urinalysis and mid-stream specimen of urine (MSSU) and mumps serology (Immunoglobulin M [IgM] and Immunoglobulin G [IgG]) performed. Twenty-three patients met inclusion criteria. Their ages ranged from 16 to 50 years, average 30.8 years. All had symptoms of these, 18 had testicular pain, eight swelling, (four had both pain and swelling) and three also had dysuria. On examination, 12 had tenderness, seven swelling, (two both tenderness and swelling) and six had no signs. Seventeen denied history of mumps, one patient had a record of vaccination and five described fever. None had parotid swelling. Three patients were chlamydia PCR positive, two had candida cultured, three had non-specific urethritis (>10 polymorphonuclear leucocyte/high powered field) and 13 had negative sexually transmitted infection screen (one known HIV-positive). Three had positive IgM mumps serology and two were IgG-positive. It is important to include mumps in the differential of epididymo-orchitis and to be aware of outbreaks in the community that may present with genital symptoms, as the management and partner notification will be different.
Interrogative suggestibility, self‐esteem, and the influence of negative life‐events
Authors: Drake Kim E. , Bull Ray , Boon Julian C. W. 
Published: May 2007

Purpose. Past research has frequently demonstrated the impact of life adversity on the behaviour and mindset of individuals. In terms of the formal police interview, the experience of negative life‐events may have an effect upon interviewee performance. This study, therefore, aims to investigate how negative life‐events may influence interviewee performance on the Gudjonsson suggestibility scale (GSS). Moreover, self‐esteem will also be investigated in relation to both the experience of negative life‐events and interrogative suggestibility.Method. Sixty participants were administered the GSS1. In between the immediate and delayed recall phases, interviewees were asked to complete the culture‐free self‐esteem inventory, the life‐events questionnaire and the Eysenck personality questionnaire.Results. Negative life‐events (NLEs) were significantly correlated with all of the GSS suggestibility scores (yield 1, yield 2, shift and total Suggestibility). Contrary to past research, however, self‐esteem scores were not significantly related to any of the GSS components or to NLE scores.Conclusion. This paper is the first to show a link between the experience of NLEs and GSS scores. The findings suggest that interviewees reporting a high number of NLEs are significantly more susceptible to the leading questions, as well as to negative feedback, administered during the GSS interview. Erroneous reports and false confessions may thus be more likely with such interviewees, potentially classifying them as vulnerable witnesses.
Rejoicing against Judaism in Handel's Messiah
Authors: MARISSEN MICHAEL 
Published: May 2007

Scholars have too little investigated questions of religious meaning in Handel's Messiah, particularly the work's manifest theological anti-Judaism. Previously unknown historical sources for the work's libretto compiled and arranged by Charles Jennens (1700–73) reveal the text's implicit designs against Jewish religion. Handel's musical setting powerfully underscores these tendencies of Jennens's libretto and adds to them, reaching a euphoric climax in the Hallelujah chorus.
Within its arrangement of juxtaposed Old Testament prophecies and their New Testament fulfillment and with its matching musical styles, Handel's Messiah could hardly have expressed more powerfully its rejoicing against Judaism than by having the ferocious tenor aria “THOU [Jesus] shalt break THEM [the Jews] with a rod of iron” answered by the chorus “Hallelujah! for the Lord God omnipotent reigneth.” The aria is a setting of Psalm 2:9, a passage that was generally and unquestioningly believed among Christians in Handel's day to have foretold the destruction of Jerusalem and its Temple in the year 70. This horrible event was construed as a divine punishment of Judaism for its failure to accept Jesus as God's promised messiah. The Hallelujah chorus apparently sees cause for rejoicing in such vengeance. Further, this chorus quotes the melodies of several hymns whose texts concern the depiction in Matthew 25 of acceptance by a bridegroom of five wise virgins and his rejection of five foolish virgins. This parable was taken to symbolize the welcoming of Ecclesia, Christianity and Jesus as the messiah, and the rejection of Synagoga and Judaism.
In 18th-century England most Christians fervently believed that a choice between Judaism and Christianity was a choice between eternal damnation and eternal salvation. This would have represented motivation indeed for Messiah to project Christian theological contempt for its sibling religion.
Collaboration and Content in the Symphonie fantastique Transcription
Authors: KREGOR JONATHAN 
Published: May 2007

Franz Liszt's transcription of Hector Berlioz's Symphonie fantastique has long been recognized for its innovative approach to musical reproduction—that is, its remarkable ability to recreate the sonic nuances of its model. However, the 1830s were a period of intense artistic and professional collaboration with Berlioz, and the genesis of the Symphonie fantastique transcription can thus also be interpreted as emblematic of this developing relationship. In particular, a gestural analysis of the work's content, as it can be recreated in part through Liszt's meticulous performance notation, indicates that the transcription served to reinforce a public perception of Berlioz as composer and Liszt as performer, whereby Liszt guides his audiences through Berlioz's enigmatic compositions by means of kinesic visual cues. Investigation of heretofore unknown manuscript materials suggests that this dynamic was further emphasized in Liszt's other renderings of Berlioz's orchestral works from the period.
For various reasons, the transcription's inherently collaborative nature failed to impress audiences outside of Paris. As Liszt embarked in earnest upon a solo career toward the end of the decade and his concert appearances with Berlioz became less frequent, interest in the work waned on the part of both arranger and audience. Moreover, it was in the late 1830s that Liszt began adding several new works to his public repertory, especially opera fantasies, Schubert song arrangements, and weighty compositions by German composers. This decision effectively removed his earlier material—including the all-too-French Symphonie fantastique—from on-stage circulation. Indeed, when Liszt revised the transcription in the 1870s, he eliminated many of extraordinary collaborative elements found in the 1834 version, thereby disassociating it from the arena for which it was created.
The Spectrum of Cardiac Anomalies in Noonan Syndrome as a Result of Mutations in the PTPN11 Gene
Authors: Sznajer Yves , Keren Boris , Baumann Clarisse , Pereira Sabrina , Alberti Corinne , Elion Jacques , Cavé Hélène , Verloes Alain 
Published: May 2007

OBJECTIVE. Noonan syndrome is a clinically homogeneous but genetically heterogeneous condition. Type 1 Noonan syndrome is defined by the presence of a mutation in the PTPN11 gene, which is found in ∼40% of the cases. Phenotype descriptions and cardiac defects from cohorts with Noonan syndrome were delineated in the “pregenomic era.” We report the heart defects and links to gene dysfunction in cardiac development in a large cohort of patients with type 1 Noonan syndrome.
METHODS. This was a retrospective, multicenter study based on clinical history, pictures, and medical and cardiologic workup over time. Data were collected by referral geneticists. Mutation screening was performed by direct sequencing of exons 2, 3, 4, 7, 8, 12, and 13 and their intron-exon boundaries, which harbor 98% of identified mutations the PTPN11 gene.
RESULTS. A PTPN11 gene mutation was identified in 104 (38.25%) of 274 patients with Noonan syndrome. Heart defect was present in 85%. The most prevalent congenital heart defects were pulmonary valve stenosis (60%), atrial septal defect, ostium secundum type (25%), and stenosis of the peripheral pulmonary arteries (in at least 15%). Pulmonary valve stenosis and atrial septal defect, ostium secundum type, were significantly associated with the identification of a mutation in the PTPN11 gene. Ventricular septal defect and most left-sided heart defects showed a trend toward overrepresentation in the group without a mutation.
CONCLUSION. We compared our data with previous series and integrated the comprehension of molecular PTPN11 gene dysfunction in heart development.