bluuebunny/crossref_metadata_2025_split huggingface dataset:
The long‐term effects of childhood circumstances on older individuals: A systematic review
Authors: Parvin Mst. Rina , Johra Fateha Tuj , Akter Fazila , Wahiduzzaman Md. , Akter Khadiza , Das Mousumi , Mondal Sujit , Debnath Mitun , Ullah Mohammad , Rony Moustaq Karim Khan 
Published: April 2024

AbstractChildhood experiences are known to shape individuals' development and can influence various aspects of life later on. Understanding the long‐term effects is crucial for informing interventions and policies aimed at promoting healthy aging. This review aimed to explore the long‐term effects of childhood experiences on older individuals. This systematic review comprised three distinct phases. Firstly, a systematic review was conducted, exploring databases such as Google Scholar, PubMed, EMBASE, PsycINFO, and the Web of Science. Out of the 2116 studies initially identified, 24 studies were selected based on the inclusion criteria. Secondly, these inclusion criteria were applied to ensure that the chosen studies specifically delved into the connection between childhood experiences and outcomes in older individuals. Finally, data extraction and synthesis techniques were employed to analyze findings, facilitating the drawing of conclusions concerning the enduring impacts of childhood experiences on the well‐being of older individuals. The review's findings revealed how negative experiences in childhood continue to affect older individuals in various ways. These early‐life events have far‐reaching consequences, profoundly impacting their physical health, making them more susceptible to chronic diseases and weakening their immune system. Additionally, they affect mental health, leading to conditions like depression, anxiety, and substance abuse. Cognitive function is also affected, resulting in memory problems and cognitive decline. Furthermore, these experiences impact social relationships, affecting trust, emotional control, and social isolation in later life. This review highlighted the enduring influence of childhood circumstances on the health and well‐being of older individuals. Policymakers and health care practitioners should consider these findings when developing strategies to support healthy aging and mitigate the long‐term effects of adverse childhood experiences.
A 2D Acridine‐Based Covalent Organic Framework for Selective Detection and Efficient Extraction of Gold from Complex Aqueous‐Based Matrices
Authors: Mei Douchao , Yan Bing 
Published: April 2024

AbstractDeveloping candidate materials which possess the ability of both selective detection and efficient capture of precious metal gold is highly desirable for environment and economy. However, most of reported materials only focus on single function, which seriously restricts their practical application as probes or adsorbents. Herein, a two dimensional (2D) acridine‐based covalent organic framework (TpDa‐COF) is prepared via the linkage of imine bonds for gold detection and adsorption. The synthesized COF can achieve both fluorescence and colorimetric dual sensing for Au3+ in a low concentration range (0.1–1.5 ppm) with the limit of detection (LOD) of 0.036 ppm. Impressively, the selectivity of TpDa‐COF for the detection of Au3+ is admirable (Fe3+, Fe2+ and Cu2+ for negligible influence on its fluorescence). In addition, TpDa‐COF exhibits ultrahigh adsorption capacity of 982.5 mg ⋅ g−1 for gold at pH=4, which is attributed the synergistic effect of both selective coordination and reductive process of Au(III) to Au(0). Meanwhile, both positive entropy change (ΔS=76.07 J ⋅ mol−1 ⋅ K−1) and high distribution coefficient (Kd=12484.8 mL ⋅ g−1) confirm the good affinity between TpDa‐COF framework and gold. This work gives us a new insight to prepare COF with pyridine nitrogen sites for gold detection and adsorption.
Synergistic Al−Al Dual‐Atomic Site for Efficient Artificial Nitrogen Fixation
Authors: Biswas Sudip , Zhou Jingwen , Chen Xue‐Lu , Chi Chen , Pan Yi‐An , Cui Peixin , Li Jian , Liu Chungen , Xia Xing‐Hua 
Published: April 2024

AbstractSynthesis of ammonia by electrochemical nitrogen reduction reaction (NRR) is a promising alternative to the Haber–Bosch process. However, it is commonly obstructed by the high activation energy. Here, we report the design and synthesis of an Al−Al bonded dual atomic catalyst stabilized within an amorphous nitrogen‐doped porous carbon matrix (Al2NC) with high NRR performance. The dual atomic Al2‐sites act synergistically to catalyze the complex multiple steps of NRR through adsorption and activation, enhancing the proton‐coupled electron transfer. This Al2NC catalyst exhibits a high Faradaic efficiency of 16.56±0.3 % with a yield rate of 29.22±1.2 μg h−1 mgcat−1. The dual atomic Al2NC catalyst shows long‐term repeatable, and stable NRR performance. This work presents an insight into the identification of synergistic dual atomic catalytic site and mechanistic pathway for the electrochemical conversion of N2 to NH3.
Disaggregation‐Activated pan‐COX Imaging Agents for Human Soft tissue Sarcoma
Authors: Tae Hong Kyung , Bin Park Seung , Murale Dhiraj P. , Hoon Lee Jung , Hwang Jangsun , Young Jang Woo , Lee Jun‐Seok 
Published: April 2024

AbstractCancer stem cells are pivotal players in tumors initiation, growth, and metastasis. While several markers have been identified, there remain challenges particularly in heterogeneous malignancies like adult soft tissue sarcomas, where conventional markers are inherently overexpressed. Here, we designed BODIPY scaffold fluorescence probes (BD‐IMC‐1, BD‐IMC‐2) that activate via disaggregation targeting for cyclooxygenase (COX), a potential marker for CSCs in sarcoma in clinical pathology. Based on their structures, BD‐IMC‐1 showcased higher susceptibility to disaggregation compared to BD‐IMC‐2, consistent with their selective interaction with COX. Notably, the BD‐IMC‐1 revealed positive cooperativity binding to COX‐2 at sub‐micromolar ranges. Both probes showed significant fluorescence turn‐on upon LPS or PMA triggered COX‐2 upregulation in live RAW264.7, HeLa, and human sarcoma cell line (Saos‐LM2) up to 2‐fold increase with negligible toxicity. More importantly, the BD‐IMC‐1 demonstrated their practical imaging for COX‐2 positive cells in paraffin‐fixed human sarcoma tissue. Considering the fixed tissues are most practiced pathological sample, our finding suggests a potential of disaggregation activated chemosensor for clinical applications.
Unraveling the Dynamic Molecular Motions of a Twin‐Cavity Cage with Slow Configurational but Rapid Conformational Interconversions
Authors: Zuo Yong , Chen Zhenghong , Li Ziying , Fu Enguang , Xin Yonghang , Chen Chenhao , Li Chenfei , Zhang Shaodong 
Published: April 2024

AbstractFeaturing diverse structural motions/changes, dynamic molecular systems hold promise for executing complex tasks. However, their structural complexity presents formidable challenge in elucidating their kinetics, especially when multiple structural motions are intercorrelated. We herein introduce a twin‐cavity cage that features interconvertible C3‐ and C1‐configurations, with each configuration exhibiting interchangeable P‐ and M‐conformations. This molecule is therefore composed of four interconnected chiral species (P)‐C3, (M)‐C3, (P)‐C1, (M)‐C1. We showcase an effective approach to decouple these sophisticated structural changes into two kinetically distinct pathways. Utilizing time‐dependent 1H NMR spectroscopy at various temperatures, which disregards the transition between mirror‐image conformations, we first determine the rate constant (kc) for the C3‐ to C1‐configuration interconversion, while time‐dependent circular dichroism spectroscopy at different temperatures quantifies the observed rate constant (kobs) of the ensemble of all the structural changes. As kobs
kc, it allows us to decouple the overall molecular motions into a slow configurational transformation and rapid conformational interconversions, with the latter further dissected into two independent conformational interchanges, namely (P)‐C3
(M)‐C3 and (P)‐C1
(M)‐C1. This work, therefore, sheds light on the comprehensive kinetic study of complex molecular dynamics, offering valuable insights for the rational design of smart dynamic materials for applications of sensing, separation, catalysis, molecular machinery, etc.
Preparation of polypropylene nanofibers reinforced multifunctional epoxy composite concrete with ultraviolet‐driven afterglow emission
Authors: Aldalbahi Ali , Thamer Badr M. , Abdulhameed Meera Moydeen , El‐Newehy Mohamed H. 
Published: April 2024

AbstractIn order to develop smart concrete with afterglow emission, epoxy resin (EPX) was immobilized with nanoparticles of alkaline earth aluminate (NAEA) as a photoluminescent agent and electrospun polypropylene nanofibers (EPN) as a reinforcement agent. Scanning electron microscope images of EPN displayed diameters of 70–90 nm, whereas transmission electron microscopic images showed that NAEA has diameters of 3–9 nm. To create a transparent sheet that glows in the dark, NAEA were physically immobilized in EPN@EPX composite. CIE Lab and photoluminescence spectrum studies demonstrated that EPN@EPX bars turned greenish upon exposure to ultraviolet (UV) rays and greenish‐yellow in a darkened box. The luminous EPN@EPX morphologies and chemical compositions were analyzed using various analytical methods. The resistance to scratching of EPN@EPX bars was monitored to considerably increase with increasing NAEA concentration. The photoluminescence spectrum demonstrated two emission peaks at 437 and 518 nm. Photoluminescent EPN@EPX hybrids with low NAEA content have shown rapid photochromism reversibility. On the contrary, NAEA‐rich EPN@EPX bars displayed slow reversibility, glowing in the dark. Superhydrophobicity and UV blockage were found to be significantly improved in the luminescent colorless EPN@EPX hybrids.
Molecular design and properties of P‐N‐B co‐intrinsic flame retardant thermosetting epoxy resin
Authors: Cheng Hengxing , Guo Junhong , Ye Yuan , Zhao Tianjing , Cui Jinfeng , Yang Baoping , Mu Bo , Tian Li , Bao Xuemei , Zhang Xiujun , Zhou Yingping , Fu Xiaohua 
Published: April 2024

AbstractCurrently, epoxy resin (EP) is widely used in various fields, but its flammability greatly limits the wider application of EP. In recent years, additive flame retardants have been widely used to enhance the flame retardancy of EPs, but poor resistance to weather and aging is a prevalent issue encountered with additive flame retardants. To improve the weather fastness, researchers have successfully created and synthesized EP molecules that possess a combined effect of P, N, and B. The results demonstrate a significant enhancement in the mechanical properties of materials containing 20% BVN/10% VPD/EP compared with those of pure EP. 20% BVN/20% VPD/EP exhibited a vertical combustion rating of V‐1 with a limiting oxygen index measuring at 29.8%. The flame retardant epoxy thermosets exhibited a notable decrease in both the maximum heat release rate and total heat release. The findings indicate that the inherent flame‐retardant properties of the P‐N‐B coacting EP are not only characterized by exceptional curing and flame retardancy but also by superior resistance to weathering and aging compared with the additive flame retardant.
Toxicological, biochemical, and in silico investigations of three trehalase inhibitors for new ways to control aphids
Authors: Neyman Virgile , Quicray Maude , Francis Frédéric , Michaux Catherine 
Published: April 2024

AbstractInsect trehalases have been identified as promising new targets for pest control. These key enzymes are involved in trehalose hydrolysis and plays an important role in insect growth and development. In this contribution, plant and microbial compounds, namely validamycin A, amygdalin, and phloridzin, were evaluated for their effect, through trehalase inhibition, on Acyrthosiphon pisum aphid. The latter is part of the Aphididae family, main pests as phytovirus vectors and being very harmful for crops. Validamycin A was confirmed as an excellent trehalase inhibitor with an half maximal inhibitory concentration and inhibitor constant of 2.2 × 10−7 and 5 × 10−8 M, respectively, with a mortality rate of ~80% on a A. pisum population. Unlike validamycin A, the insect lethal efficacy of amygdalin and phloridzin did not correspond to their trehalase inhibition, probably due to their hydrolysis by insect β‐glucosidases. Our docking studies showed that none of the three compounds can bind to the trehalase active site, unlike their hydrolyzed counterparts, that is, validoxylamine A, phloretin, and prunasin. Validoxylamine A would be by far the best trehalase binder, followed by phloretin and prunasin.
Sensitive osteoarthritis sensing by salt‐induced aggregation and dispersion of gold nanoparticles
Authors: Fan Yong , Li Renjie , Deng Xuekai , Li Ming , Zhou Yu , Wu Dan , Liu Gang 
Published: April 2024

AbstractOsteoarthritis occurs in any joints, and identification in its earlier stages helps to treat the disease and increase the recovery rate. The radiography method and imaging techniques are traditionally used to identify osteoarthritis. But these methods are expensive, and with the complicated steps. Researchers are working toward developing a highly sensitive biosensor in identifying the osteoarthritis biomarker. This research was focused on developing a C‐terminal telopeptide of type II collagen (CTX‐II) colorimetric sensor with gold nanoparticle (AuNP) for diagnosing osteoarthritis. Anti‐CTX‐II was conjugated with AuNP and then added with CTX‐II and sodium chloride for the color change. In the presence of CTX‐II, antibody releases from AuNP then binds with CTX‐II, and the color of AuNP changed to purple. Without the CTX‐II, AuNP remains its red color (dispersed). This easier colorimetric assay detected the CTX‐II as low as 2 ng/mL on linear regression [y = 0.0131x − 0.0051; R2 = 0.9205]. Furthermore, control performances with the relevant proteins osteopontin, IL‐6, and nonimmune antibody failed to change the color confirming the specific identification of CTX‐II.
Unveiling the Supercapacitive Performance of B, P Dual‐Doped Graphene in Triple Redox Additives
Authors: Suresh Balaji S. , Vignesh V. , Pandurangan A. 
Published: April 2024

AbstractDual heteroatom doping of graphene is currently presumed as more promising for energy storage applications. In addition, the development of energy density with multiple redox additives is paying special attention. Here, we report the fabrication of B, P dual‐doped graphene in three various weight combinations. The formation and the quantity of the prepared samples were investigated by XRD, FT‐IR, EDAX and XPS. The B, P dual‐doped graphene derived from the weight ratio of boron and phosphorus dopant in 1 : 3 has achieved an enriched gravimetric capacitance of 360 F g−1 at 1 A g−1 (1 M H2SO4) and greater than RGO (151 F g−1). The energy density of the fabricated symmetric supercapacitor cell is found to be 50 Wh kg−1 in triple redox additives in 1 M H2SO4 solution which is greater than KI (33 Wh Kg−1) and 1 M H2SO4 alone (5 Wh Kg−1) at 2 A g−1. Also, the same cell delivered an increased stability of 99.7 % of capacitance retained from its initial value after 7000 charge–discharge cycles at 5 A g−1.
A systemic approach to identifying sequence frameworks that decrease mAb production in a transient Chinese hamster ovary cell expression system
Authors: Szkodny Alana C. , Lee Kelvin H. 
Published: April 2024

AbstractMonoclonal antibodies (mAbs) are often engineered at the sequence level for improved clinical performance yet are rarely evaluated prior to candidate selection for their “developability” characteristics, namely expression, which can necessitate additional resource investments to improve the manufacturing processes for problematic mAbs. A strong relationship between primary sequence and expression has emerged, with slight differences in amino acid sequence resulting in titers differing by up to an order of magnitude. Previous work on these “difficult‐to‐express” (DTE) mAbs has shown that these phenotypes are driven by post‐translational bottlenecks in antibody folding, assembly, and secretion processes. However, it has been difficult to translate these findings across cell lines and products. This work presents a systematic approach to study the impact of sequence variation on mAb expression at a larger scale and under more industrially relevant conditions. The analysis found 91 mutations that decreased transient expression of an IgG1κ in Chinese hamster ovary (CHO) cells and revealed that mutations at inaccessible residues, especially those leading to decreases in residue hydrophobicity, are not favorable for high expression. This workflow can be used to better understand sequence determinants of mAb expression to improve candidate selection procedures and reduce process development timelines.
Investigations of Limeum Indicum Plant for Diabetes Mellitus and Alzheimer's Disease Dual Therapy: Phytochemical, GC‐MS Chemical Profiling, Enzyme Inhibition, Molecular Docking and In‐Vivo Studies
Authors: Shamim Tahira , Asif Hafiz Muhammad , Abida Ejaz Syeda , Hussain Zahid , Wani Tanveer A. , Sumreen Laila , Abdullah Muhammad , Ahmed Zubair , Iqbal Jamshed , Kim Song Ja , Shah Muhammad Kamal 
Published: April 2024

AbstractLimeum indicum has been widely utilized in traditional medicine but no experimental work has been done on this herb. The primary objective of this study was to conduct a phytochemical analysis and assess the multifunctional capabilities of aforementioned plant in dual therapy for Alzheimer′s disease (AD) and Type 2 diabetes (T2D). The phytochemical screening of ethanol, methanol extract, and their derived fractions of Limeum indicum was conducted using GC‐MS, HPLC, UV‐analysis and FTIR. The antioxidant capacity was evaluated by DPPH method. The inhibitory potential of the extracts/fractions against α‐, β‐glucosidase acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and monoaminine oxidases (MAO‐A & B) was evaluated. Results revealed that acetonitrile fraction has highest inhibitory potential against α‐glucosidase (IC50=68.47±0.05 μg/mL), methanol extract against β‐glucosidase (IC50=91.12±0.07 μg/mL), ethyl acetate fraction against AChE (IC50=59.0±0.02 μg/mL), ethanol extract against BChE (28.41±0.01 μg/mL), n‐hexane fraction against MAO‐A (IC50=150.5±0.31 μg/mL) and methanol extract for MAO‐B (IC50=75.95±0.13 μg/mL). The docking analysis of extracts\fractions suggested the best binding scores within the active pocket of the respective enzymes. During the in‐vivo investigation, ethanol extract produced hypoglycemic effect (134.52±2.79 and 119.38±1.40 mg/dl) after 21 days treatment at dose level of 250 and 500 mg/Kg. Histopathological findings further supported the in‐vivo studies.
Chemical Constituents from the deep‐sea‐derived Fungus Aureobasidium melanogenum LUO5
Authors: Dong Hao‐Yu , Wang Yuan , Zhang Xiao‐Yu , Zhang Meng , Yang Long‐He , Zou Zheng‐Biao , Li You , Xie Ming‐Min , Yang Xian‐Wen , Wang Bin 
Published: April 2024

AbstractThree new C10 and C12 aliphatic δ‐lactones (1–3), three new fatty acid methyl esters (4–6), and eight known compounds (7–14) were isolated from the marine Aureobasidium sp. LUO5. Their structures were established by detailed analyses of the NMR, HRESIMS, optical rotation, and ECD data. All isolates were tested for their inhibitory effects on nitric oxide production in LPS‐induced BV‐2 cells. Notably, compound 4 displayed the strongest inhibitory effect with the IC50 value of 120.3 nM.
New Antibacterial 1,3,4‐Thiadiazole Derivatives With Pyridine Moiety
Authors: Şener Nesrin , Aldwib Aiman Emhemad Omeran 
Published: April 2024

Abstract1,3,4‐Thiadiazole compounds were synthesized using pyridine carboxylic acid derivatives and thiosemicarbazide derivatives. The molecular structures of the resulting compounds were characterized by spectroscopic methods such as ATR‐FTIR, 1H‐NMR, and elemental analysis. Its compounds were also examined for their antibacterial properties against some strains of bacteria. Five synthesized compounds showed varying antibacterial effects on Escherichia coli, Salmonella kentucky, Bacillus substilis and Klebsiella pneumoniae. This result revealed that some of the resulting compounds could be antibacterial agents.
State of the Art of Methanol Reforming for Hydrogen Generation
Authors: B. S. Thirumalesh , Asapu Ramesh 
Published: April 2024

AbstractGreen hydrogen is the energy carrier set in the roadmap to achieve the net zero target. However, hydrogen as the future energy vector, either in compressed gaseous form or liquefied form, demands a complete overhaul of storage and transportation infrastructure at a global scale. Methanol is one of the commercially viable hydrogen carriers that can overcome the infrastructure challenges associated with the storage and transportation of hydrogen. As a sustainable hydrogen carrier, methanol must be reformed to hydrogen prior to the point of usage. This review begins with a detailed discussion on thermocatalytic methanol reforming, catalysts, operating conditions, and the associated challenges for both stationary and mobility applications. An in‐depth analysis of the existing commercial methanol reformers available for on‐board and onsite hydrogen generation is also presented. The current state of the research‐level photo‐ and electroreforming as a possible alternative to thermocatalytic reforming is reviewed and concludes with the future prospects for methanol reforming.
Chemistry of Strigolactones, Key Players in Plant Communication
Authors: Daignan‐Fornier Suzanne , Keita Antoinette , Boyer François‐Didier 
Published: April 2024

AbstractToday, the use of artificial pesticides is questionable and the adaptation to global warming is a necessity. The promotion of favorable natural interactions in the rhizosphere offers interesting perspectives for changing the type of agriculture. Strigolactones (SLs), the latest class of phytohormones to be discovered, are also chemical mediators in the rhizosphere. We present in this review the diversity of natural SLs, their analogs, mimics, and probes essential for the biological studies of this class of compounds. Their biosynthesis and access by organic synthesis are highlighted especially concerning noncanonical SLs, the more recently discovered natural SLs. Organic synthesis of analogs, stable isotope‐labeled standards, mimics, and probes are also reviewed here. In the last part, the knowledge about the SL perception is described as well as the different inhibitors of SL receptors that have been developed.
A novel approach to saline/contrast delivery in excimer laser coronary atherectomy (ELCA) to enhance efficacy: MAXCon ELCA technique
Authors: Case Brian C. , Bazarbashi Najdat , Johnson Adam , Rogers Toby , Ben‐Dor Itsik , Satler Lowell F. , Waksman Ron , Hashim Hayder D. , Gallino Robert , Bernardo Nelson L. 
Published: April 2024

AbstractThe advent of excimer laser coronary atherectomy (ELCA) nearly four decades ago heralded a novel way to treat complex lesions, both coronary and peripheral, which were previously untraversable and thus untreatable. These complex lesions include heavily calcified lesions, ostial lesions, bifurcation lesions, chronic total occlusions, in‐stent restenosis (including stent underexpansion), and degenerative saphenous vein grafts. We discuss the technology of ELCA, its indications, applications, and complications, and suggest the “MAXCon ELCA” technique for better outcomes without increased risk. Lastly, we present a case of MAXCon ELCA effectively treating a complex lesion.