bluuebunny/crossref_metadata_2025_split huggingface dataset:
La conjugaison des temps et ses aléas confusionnels en périnatalité
Authors: Darchis Élisabeth 
Published: March 2024

La période périnatale suscite un bouleversement psychique de la famille où le passé, le présent et le futur s’entremêlent. Quand des traumatismes ont affecté des générations en amont, il est possible qu’un passé non élaboré resurgisse à la naissance d’un enfant. Des organisations défensives délétères se transmettent sans transformation. Une confusion des temps peut s’installer, entre passé et présent, obturant le futur, plongeant la nouvelle famille dans de la désorganisation, faisant apparaître des symptômes. Les autrices proposent un éclairage théorique, puis des vignettes cliniques dont un accompagnement de thérapie familiale psychanalytique périnatale pour permettre à la nouvelle famille de se différencier et de construire un avenir détoxifié et « déconfusionné ». Le développement favorable de l’enfant et une parentalité plus harmonieuse peuvent en découler au bénéfice de tous.
L’exercice de la psychologie : se retrouver et échanger sur de nouvelles perspectives
Authors: Garcin Emmanuel 
Published: March 2024

Si l’exercice de la psychologie repose sur une base commune en termes d’éthique professionnelle et de nomenclature, les psychologues utilisent néanmoins des outils différents selon leur orientation, mais aussi en réponse à une multiplicité de contextes cliniques. En organisant le forum « Psychologie : nouvelles perspectives » présenté ici par l’auteur, le Collège des psychologues de l’hôpital de Rouffach a donné l’occasion aux psychologues de se retrouver et d’échanger sur leurs pratiques et sur les nouvelles modalités d’exercice de la psychologie au regard des évolutions de notre société.
Extensive Endolaser During Vitrectomy for Primary Rhegmatogenous Retinal Detachment Is Associated With Epiretinal Membrane Formation
Authors: Cakir Bertan , Peacker Bryan L. , Zeng Rebecca , Tracy Jack H. , Feng Yilin , Miller John B. 
Published: March 2024

Background and Objective:
Epiretinal membrane (ERM) formation, a common complication following pars plana vitrectomy (PPV) for primary rhegmatogenous retinal detachment (RRD) repair, is associated with vision loss and metamorphopsias. Although laser retinopexy is generally associated with ERM formation, the correlation between the extent of laser treatment and ERM formation during PPV is not well established. The aim of this study was to identify risk factors associated with ERM formation including extend of endolaser retinopexy after PPV for primary RRD.

Patients and Methods:
A retrospective, observational case series of 181 consecutive patients (185 eyes) who underwent PPV for primary RRD repair by a single surgeon was performed. Charts were reviewed by two independent reviewers, and de-identified data including patient characteristics and intraoperative findings such as number of laser spots placed were recorded.

Results:

Postoperative ERM formation occurred in 75 eyes (40.5%) of which 68 (90.6%) were Stage 1, two (2.6%) were Stage 2, three (4%) were Stage 3, and two (2.6%) were Stage 4. Only one patient required secondary PPV for visually significant ERM. Patients with ERM had significantly more laser spots compared with patients with no ERM, with a mean of 807 and 519 laser spots respectively (95% CI: 387.6 to −187.3;
P
< 0.0001). Univariable analysis identified ≥750 endolaser spots (odds ratio [OR] = 4.0, 95% CI: 2.0 to 8.4;
P
< 0.0001), ≥4 retinal tears (OR = 2.8, 95%: CI 1.4 to 6.4;
P
= 0.005), and female sex (OR = 2.0, 95% CI: 1.1 to 3.7;
P
= 0.02) as significantly associated factors. After adjusting for potential confounding factors (ie, age, sex, macula status, lattice degeneration, length of symptoms, vitreous hemorrhage, number of endolaser spots, number of retinal tears) in multivariable logistic regression, ≥ 750 endolaser spots (OR = 2.4;
P
= 0.04) and female sex (OR = 2.4;
P
= 0.03) persisted as significant independent factors.

Conclusions:
Our study identified ≥ 750 laser spots and female sex as independent risk factors for ERM formation following PPV for RRD with an OR of 2.4 each. Although the incidence of ERM formation was generally high (40.5%), only one case required secondary PPV with ERM peeling, and visual outcomes were comparable between patients with and without ERM at final follow up. While endolaser photocoagulation is critical for successful RRD repair, consideration of the risk of ERM formation with extensive laser exposure is warranted.

[
Ophthalmic Surg Lasers Imaging Retina
2024;55:326–333.]
Chemical composition and mosquitocidal activity of methanolic leaf extracts from Ziziphus mauritiana L. against Aedes aegypti L. and Culex quinquefasciatus Say
Authors: Sumathi Ganesan , Pushpanathan Thambusamy , Abhirami Muthukumar 
Published: March 2024

Background & objectives:
Mosquito vectors are a significant cause of pathogen transmission to both animals and humans. Mosquitoes are responsible for transmitting various diseases, including chikungunya, filariasis, West Nile fever, dengue, malaria, and Zika fever, placing approximately 80% of the world’s population at risk of infection at any given time. Controlling mosquitoes has become a multifaceted challenge, influenced by diverse environmental factors such as deforestation, urbanization, and climate change on a global scale. For centuries, medicinal plants have been utilized as bioinsecticides to control insect pests. Ziziphus mauritiana, also known as Chinese apple or Indian jujube is a deciduous thorny tree or shrub. Different parts of the Z. mauritiana plant have been traditionally used to treat various common diseases, a practice still prevalent in India and China.

Methods:
In the current investigation, the chemical properties of Z. mauritiana leaf extract were examined through UV-Vis Spectroscopy, Fourier Transform Infra-Red Spectroscopy (FTIR), and GC-MS Analysis. Second and fourth instar larvae, as well as pupae, of Aedes aegypti and Culex quinquefasciatus were subjected to different concentrations of the methanolic extract of Z. mauritiana for 24 h and 48 h to assess larvicidal and pupicidal activity.

Results:
The FT-IR spectrum analysis revealed the presence of various functional groups in the chemical compounds extracted from Z. mauritiana, including amines, aromatics, alkanes, alkyls, carbonyls, and carboxylic acids. Additionally, GC-MS analysis identified Isoborneol (25.37%), 4-Acetylbutyric Acid (26.82%), and 2-Vinyl- 9-[Beta-D-Ribofuranosyl] Hypoxanthine (24.24%) as the three major phytoconstitutents in the methanol extracts of Z. mauritiana. Regarding the larvicidal activity, the methanolic extract of Z. mauritiana exhibited LC50 values of 155.67 mg/L and 208.57 mg/L for second instar larvae, and 177.68 mg/L and 252.13 mg/L for fourth instar larvae of Cx. quinquefasciatus and Ae. aegypti, respectively, after 24 h of exposure. For pupicidal activity, the LC50 values were 502.02 mg/L and 514.99 mg/L on pupae of Cx. quinquefasciatus and Ae. aegypti, respectively, within 24 h.

Interpretation & conclusion:
Overall, the GC-MS analysis provides valuable insights into the chemical composition of the Z. mauritiana extract, highlighting its potential as a natural and eco-friendly alternative for combating insect vectors and contributing to integrated mosquito management programs.
Prevalence and morphology of middle mesial canal in mandibular first molars in an Indian sub-population: A cone-beam computed tomographic analysis
Authors: Bharatiya Rajendra P , Ujariya Urvashi M , Kothari Anjali K , Shah Viraj Yogesh , Naik Malhar Hemantbhai 
Published: March 2024

Aim:
The aim of this study was to check for the prevalence and morphology of middle mesial (MM) canals in mandibular first molars in an Indian population divided as per the different zones of the country using cone-beam computed tomography (CBCT) scans.

Methods:
A total of 452 CBCT scans were selected according to the inclusion and exclusion criteria on December 2021. The scans were obtained from five different zones of the country with 80–100 scans selected from each zone. They were checked in an axial view to see for the presence of a MM canal (MMC) and if present, were confirmed in a coronal view.

Results:
Of the 452 scans viewed, 39 showed the presence of MMCs (8.6%). Bilateral presence was seen in 8 scans (1.8%). Hence, overall, 47 molars out of 904 examined showed the presence of MMCs. Thus, the tooth prevalence rate for the presence of MMC was 5.2%. Seventy percent of teeth presenting with MMCs showed two apical exits. Males showed more prevalence when compared to the female population (10.25% vs. 6.88%, P < 0.05). Furthermore, with increasing age, there was a consistent decrease in the incidence of MMCs (P < 0.05).

Conclusion:
Overall, the prevalence of MMCs in an Indian sub-population is 8.6%. Although on a lower range compared to other population, careful exploration is necessary to avoid missing the MMC which might lead to failure of treatment. Age and gender are also found as the important factors that influence the presence of a MMC.
Comparative evaluation of the auxiliary effect of different herbs to enhance the antibacterial efficacy of calcium hydroxide against Enterococcus faecalis biofilm – An in vitro study
Authors: Hiremath Hemalatha , Verma Devansh , Solanki Aishwarya Singh , Patidar Sonam 
Published: March 2024

Aim:
The increase in potential side effects and safety concerns of conventional medicaments has led to the recent popularity of herbal alternative medications. The herbal products are known for their high antimicrobial activity, biocompatibility, anti-inflammatory, and antioxidant properties. The present study was designed to compare the effectiveness of calcium hydroxide (CH) in combination with various herbs as intracanal medicaments against Enterococcus faecalis biofilm.

Methods:
Forty extracted single-rooted maxillary teeth were decoronated and sectioned into two halves. They were later infected with E. faecalis to form a biofilm for 21 days. Subsequently, the root samples were divided into a control group and three experimental groups – the control group was treated with CH powder mixed with distilled water and the experimental Group 1 was treated with CH powder and aloe vera gel placed over PerioCol-guided tissue regeneration (GTR) membrane; Group 2 was treated with CH powder mixed with coronil, and incorporated with aloe vera gel; and Group 3 was treated with CH powder mixed with Ajmodadi Churna incorporated with aloe vera gel. At the end of 7 and 14 days, the antimicrobial efficacy of medicaments against E. faecalis biofilm was assessed at the depths of 200–400 μm. Kruskal–Wallis test and post hoc analysis – Mann–Whitney test were used for statistical analysis.

Results:
Ajmodadi Churna was most effective followed by coronil and CH placed over the PerioCol GTR membrane.

Conclusion:
Ajmodadi Churna exhibited superior results. Coronil displayed good efficacy against E. faecalis in long-term use and thus could be used as an effective intracanal medicament. Among the Ayurvedic preparations, both hold a promising future but to implement their use as sole intracanal medicaments clinically, further in vivo and long-term studies are warranted.
Effect of different irrigation activation systems using continuous chelating irrigation protocol on the removal of smear layer in the apical third of root canals: An in vitro scanning electron microscope study
Authors: D’Souza Nikitha , Santhosh Ashwini , Kumari Anitha , Murthy Chethana S , Gowda Vikram , Mallandur Sudhanva 
Published: March 2024

Aim:
Continuous chelation is a novel irrigation regimen popular as a single solution for irrigation of the root canal system during root canal therapy, especially for the removal of the smear layer. This study aimed to compare the effectiveness of three different irrigation activation systems in removing the smear layer from the apical third in single-rooted mandibular premolars using a scanning electron microscope (SEM).

Methods:
Fifty-six extracted single-rooted mandibular premolars were decoronated, and canals prepared till #30/0.09, with Chloroquick (3% NaOCl + 9% HEBP) as the working solution. Teeth were randomly divided into four groups based on the final irrigant activation protocol; Group A - (control group) conventional syringe irrigation with a 30-gauge single-side vented needle. Group B - (passive ultrasonic irrigation method) passive ultrasonic irrigation (PUI) with #20-Irrisafe ultrasonic files activated for 1 min. Group C - (sonic activation) EndoActivator system using the yellow tip (#20/0.04) activated for 1 min. Group D - Tornado Disinfection Kit using GF-brush for 20–30 s as per manufacturer’s instructions. The canals were dried, samples were hemi-sectioned, and the amount of remaining smear layer was scored according to the Tabrizizadeh criteria (2015) with SEM images at ×2500 by two blinded operators. The collected data were analyzed statistically using the Chi-square test (P < 0.05).

Results:
The results showed statistically significant differences in terms of smear removal among the groups (P < 0.05) with the Gentlefile group performing better, followed by PUI, EndoActivator, and the conventional group.

Conclusion:
Within the limitations of the study, continuous chelation with Gentlefile activation could be a viable and efficient protocol for the removal of the smear layer from the apical third of root canals.
Comparison of antimicrobial efficacy of green tea extract and Triphala as root canal irrigants against Fusobacterium nucleatum using real-time polymerase chain reaction – An in vitro study
Authors: Chandran Keerthana , Sridhar Dinesh , John Bindu Meera , Jayakumar Srilekha , Arumugam Karthikeyan , Ponnusamy Prashanth 
Published: March 2024

Aim:

Fusobacterium nucleatum has gained attention in the endodontic literature as it is a predominant microorganism in primary, secondary, and persistent root canal infections. Current irrigants have lot of drawbacks and are unlikely to predictably achieve a bacteria-free root canal system, which can lead to these failures. Herbal alternatives are now gaining popularity in the field of endodontics, paving a new way in the disinfection of root canals. The aim of this study is to evaluate the antimicrobial efficacy of green tea extract and Triphala as root canal irrigants against F. nucleatum using real-time Polymerase chain reaction (PCR).

Methods:
Extracted teeth were taken and inoculated with F. nucleatum, which was grown in a Mueller–Hinton agar plate under anaerobic conditions. The samples were cleaned and shaped and irrigated with green tea extract, Triphala extract, and dimethyl sulfoxide, which were compared to the widely used irrigant, sodium hypochlorite. Cycle threshold value was used to calculate the efficacy of the irrigant against F. nucleatum after which the samples were subjected to reverse transcriptase PCR. The data were analyzed and the data between the group were compared using the one-way ANOVA followed by a post hoc Tukey’s test.

Results:
Triphala extract demonstrated high antimicrobial activity against F. nucleatum1. It revealed statistically significant differences between Triphala extract and sodium hypochlorite (NaOCL) (P = 0.001). Green tea extract also displayed antimicrobial activity. Both the Triphala and green tea extracts showed a significant difference (P < 0.001).

Conclusion:
Triphala extract showed better antibacterial efficacy when compared to 3% NaOCl and green tea extract against F. nucleatum.
Iron Supplementation May Improve the Patient’s Level of Satisfaction in Not-Low-Ferritin Telogen Effluvium: A Real-Life Observational Study
Authors: Soutou Boutros , Rahme Serena , Bizdikian Aren Joe , Skaff Stéphanie , Helou Josiane , Tomb Roland 
Published: March 2024

Abstract

Background:
Telogen effluvium (TE) is the most common cause of alopecia in women. Treatment should address the etiological factors and may include adjuvant therapies. In practice, physicians may employ modified approaches and utilize various combinations of topical and oral molecules.

Aims:
In this real-life observational study, the aim was to evaluate the response of TE to iron supplementation.

Materials and Methods:
The population consisted of all patients who sought consultation for TE at our dermatology department between March 2021 and February 2022. Eligible participants were women, aged between 18 and 65, having a clinical diagnosis of TE, and intended for treatment with iron supplementation. Exclusion criteria comprised current pregnancy, chronic or active inflammatory disease, newly discovered dysthyroidism, concurrent use of hair supplements, topical minoxidil, or any other medications. The response was assessed based on the patient’s level of satisfaction, a significant indicator, given the substantial psychological impact of TE on women’s daily lives.

Results:
The analysis included 200 women. The average age was 32.9 ± 11.4 years. A recent history of COVID-19 or treated dysthyroidism was present in 18.5% and 8% of patients, respectively, but did not impact their response. Significantly, patients with baseline ferritin ≥50 ng/ml were mostly “very satisfied”, those with baseline ferritin <50 ng/ml were mostly “not satisfied”, and those with unknown levels were mostly “partially satisfied” with iron supplementation. A high dose of elemental iron and a prolonged duration of treatment significantly improved the patients’ level of satisfaction.

Conclusion:
Iron supplementation can improve the patient’s level of satisfaction in TE even if serum ferritin is not low.
A Study of Nodular Glomerulopathy – A Single-center Experience and Review
Authors: Sivagnanam Harish , Kumar P. K. Senthil , Velu Kannan Bhaba , Anand S. Murugesh , Ammayappan Shiva Kumar , Vishwanathan Ramasubramanian , Palaniselvam Shankar 
Published: March 2024

ABSTRACT

Background:
Mesangial expansion is a histopathological manifestation characterized by abnormal proliferation of mesangial cells and accumulation of matrix proteins within the central region of the glomerulus. While diabetes is a well-known cause of mesangial expansion, several rare diseases can also present with this pathology. This study aimed to estimate the prevalence of lesions exhibiting mesangial expansion in a tertiary care center in Tirunelveli, India, and elucidate the spectrum of disorders contributing to mesangial expansion lesions in renal biopsies.

Methodology:
A retrospective analysis of renal biopsies conducted at Tirunelveli Medical College and Hospital from 2016 to 2022 was performed. Kidney tissue samples were subjected to light microscopy and immunofluorescence studies using appropriate stains. Patients with isolated mesangial expansion were identified. Demographic details, clinical indications for biopsy, and pathological findings were recorded and analyzed.

Results:
Out of 616 kidney biopsies, mesangial expansion was present in 39 patients (6.33%). Notably, nodular mesangial expansion was observed in 33 patients (5.3%), with diabetes being the most prevalent associated condition (74.19%). Amyloidosis, heavy chain deposition disease, fibrillary glomerulonephritis, collagen fibrotic glomerulopathy, and idiopathic nodular glomerulosclerosis were identified as other contributors to mesangial expansion. Glomerular filtration rate and interstitial fibrosis and tubular atrophy were worse in the diabetic population.

Conclusions:
This study sheds light on the varied etiologies contributing to mesangial expansion beyond diabetes, emphasizing the importance of specialized staining methods for precise diagnosis.
Clinical Profile and Outcomes of Hospitalized Coronavirus Disease-2019 Patients Requiring Renal Replacement Therapy at a Tertiary Care Center
Authors: Chauhan Ashish , Singh Ram , Sharma Dheeraj , Sandal Rajeev , Verma Balbir , Chauhan Naresh , Vikrant Sanjay , Gupta Samriti , Kumar Asheesh 
Published: March 2024

ABSTRACT

Introduction:
Patients with coronavirus disease-2019 (COVID-19) infection who have underlying chronic kidney disease (CKD) or experience acute kidney injury (AKI) are at an increased risk of severe disease and mortality.

Materials and Methods:
This single-center retrospective study was conducted at a tertiary care center offering hemodialysis (HD) facilities to COVID-19-positive patients. We included COVID-19-positive patients aged >18 years who received HD during their hospital stay. Patients were classified as CKD-5D, acute on CKD, and AKI stage-3 (AKI-3D).

Results:
Severe disease was seen in ~60% of patients, with a higher overall mortality (46.15%). However, there was no significant difference in mortality between CKD-5D (n = 70), acute on CKD (n = 32), and AKI-3D (n = 15) groups (42.9% vs. 53.1% vs. 46.7%, P = 0.627). Advanced age, diabetic status, severe disease, and raised inflammatory markers were predictors of mortality.

Conclusion:
Among patients with COVID-19, severe renal disease requiring dialysis is associated with high mortality. We did not see any significant difference in mortality in either AKI or CKD subgroups.
Role of Arterial Lactate and Lactate Clearance in Risk Stratification of Patients with Upper Gastrointestinal Bleeding Presenting to the Emergency Department for use at Primary Health Care Level
Authors: Kaliparambil Binoy Xavier , Maprani Jobin Jose , Paulson Sandra 
Published: March 2024

Abstract

Background:
Upper gastrointestinal bleeding is a common presenting complaint in the emergency department (ED) and carries a small but significant mortality rate. In spite of the availability of various scoring systems, risk stratification for in hospital morbidity and mortality remains difficult. There is no single test that can reliably predict active bleeding from the upper gastrointestinal tract for use at primary health level.

Aims and Objectives:
To study the role of lactate clearance as a predictor of active bleeding and also to determine whether an ED arterial lactate can predict adverse outcomes like increased hospital length of stay, in hospital, 30-day and 60-day mortality.

Methods and Material:
Prospective single centre observational study at a tertiary hospital in north Kerala that included all stable adult patients who presented with the complaints of hematemesis, melena or both to the ED Arterial lactate was drawn at the bedside, a priori initial arterial lactate cut-off value of 2.2 mmol/L was selected and in patients with lactate value above the cut-off, a second lactate was measured to calculate lactate clearance.

Results:
Lactate clearance ≤13.39% was found to be associated with a high risk for active bleeding (odds ratio: 23.33; 95% CI = 4.337 to 125.512, P < 0.001). Optimal cut-off points for lactate as well as lactate clearance were derived using receiver operating characteristics curve.

Conclusions:
Lactate clearance can reliably rule in as well as rule out active bleeding in patients who might seem hemodynamically stable at the initial presentation to the ED.