bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Training and Career Development on Company Performance: A Systematic Literature Review
Authors: Fabian Natanael Tio , Kirani Agnes Neisha , Dewi Puja Kalima , Gracia Ribka , Loei Jonathan , Muyandi Muhammad Rachman , Kalfin  
Published: March 2024

Company performance in the business era is something that needs to be considered in maintaining the continuity of a company. Training and career development are one of the variables that affect company performance. Therefore, this study will look at the effect of training and career development on employee performance based on literature review. In this study using article data that has been published in google scholar indexed journals from 2013-2023. This study uses a systematic literature review method in obtaining the expected results. Based on the results of the analysis obtained that training and career development have a role in improving employee performance. Training on employee performance has an important relationship. With training, employees can develop skills, as well as various kinds of new knowledge. Along with the training conducted by the company, the performance produced by employees will also increase which will affect the development of the company. Likewise, with career development in the company, it will trigger employee enthusiasm to work harder, motivate employees, and attract employees to work for a long time in the company. Based on the results of this study, it is hoped that it can be a reference for companies in improving employee performance. Of course, by paying attention to variables of training and career development.
Rituximab for rheumatoid arthritis-related interstitial lung disease: A systematic review and meta-analysis
Authors: Krishna Boppana Tarun , Mittal Saurabh , Madan Karan , Mohan Anant , Hadda Vijay , Guleria Randeep 
Published: March 2024

Objectives: This systematic review and meta-analysis aimed at summarizing the evidence of efficacy and safety of rituximab in rheumatoid arthritis- related interstitial lung disease (RA-ILD).
Materials and methods: PubMed and Embase databases were searched until June 22, 2022, to identify studies on RA-ILD treated with rituximab, confined to predefined inclusion and exclusion criteria. A systematic review and meta-analysis were performed on the included studies to assess the overall stabilization or improvement in ILD, changes in percent-predicted (%-predicted) forced vital capacity (FVC), and %-predicted diffusion capacity of lungs for carbon monoxide (DLCO) following rituximab therapy.
Results: A total of 15 studies (4 prospective and 11 retrospective studies) were included, with a total of 314 patients. There were 105 (60.7%) females out of 173 subjects for whom sex details were available from seven studies. The overall pooled proportion of patients with stabilization or improvement in ILD was 0.88 [95% confidence interval (CI): 0.76-0.96, p=0.02]. Rituximab improved FVC from baseline by 7.50% (95% CI: 1.35-13.65; p=0.02, fixed effect). Similarly, rituximab improved DLCO by 6.39% (95% CI: 1.366-14.43; p=0.12, random-effect). Two retrospective studies reported reduced mortality with rituximab therapy compared to tumor necrosis factor-alpha inhibitors.
Conclusion: Treatment with rituximab in RA-ILD was associated with a significant improvement in %-predicted FVC, as well as stabilization or improvement in ILD after one year of treatment.
The relationship between clinical parameters and ultrasonographic enthesitis assessment in patients with spondyloarthritis
Authors: Er Gunay , Palamar Deniz , Akgün Kenan , Asoğlu İbrahim , Sarı Hidayet 
Published: March 2024

Objectives: The study aimed to evaluate the role of ultrasonographic assessment of enthesitis in patients with spondyloarthritis (SpA) in terms of disease activity, functionality, and quality of life.
Patients and methods: Ninety SpA patients (57 males, 33 females; mean age: 37.5±9.7 years; range, 18 to 60 years) were included in cross-sectional study between November 2016 and January 2017. Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Ankylosing Spondylitis Disease Activity Score (ASDAS), Bath Ankylosing Spondylitis Functional Index (BASFI), Short Form-12 (SF-12), and Ankylosing Spondylitis Quality of Life (ASQoL) were utilized for clinical evaluation. The clinical evaluation of enthesitis was performed with the Spondyloarthritis Research Consortium of Canada (SPARCC) and Maastricht Ankylosing Spondylitis Enthesitis Score (MASES) via an algometer calibrated to 4 kg/cm2 of pressure. Ultrasound evaluation was performed according to Madrid Sonographic Enthesitis Index (MASEI). A total of 2,610 entheseal sites were examined clinically, and 1,080 were assessed ultrasonographically.
Results: A significant proportion of enthesitis (463/1,080) was detected on ultrasonographic evaluation but not with clinical enthesitis score (MASES and SPARCC). Although ultrasonographic entheseal evaluation detected enthesitis in at least one enthesis of all patients, 35 of the patients had no enthesitis with clinical examination. The sites most frequently involved in the entheses were the proximal patellar tendon and Achilles tendon. The MASEI score did not correlate with the MASES, SPARCC, BASDAI, SF-12, and ASQoL but moderately correlated with the C-reactive protein (CRP) level (r=0.348), ASDAS-CRP (r=0.294), and BASFI score (r=0.244).
Conclusion: The association of ultrasonography scores with CRP levels and ASDAS-CRP indicates that ultrasonography is effective in detecting inflammation. The MASEI score weakly correlates with functionality but not with quality of life. Ultrasonographic evaluation is invaluable and merits to be incorporated into SpA disease scoring system.
Performance of the 2022 American College of Rheumatology/European Alliance of Associations for Rheumatology Classification Criteria for antineutrophil cytoplasmic antibody-associated vasculitis in previously diagnosed adult patients from Türkiye
Authors: Yilmaz Sedat , Kucuk Hamit , Sungur Ozgunen Merve , Can Kardas Riza , Tecer Duygu , Vasi Ibrahim , Cinar Muhammet , Akif Ozturk Mehmet 
Published: March 2024

Objectives: This study aimed to evaluate the applicability of the new 2022 American College of Rheumatology (ACR)/European Alliance of Associations for Rheumatology (EULAR) criteria in Turkish adult patients previously diagnosed with antineutrophil cytoplasmic antibody-associated vasculitis (AAV).
Patients and methods: One hundred sixty-four patients (96 males, 68 females; mean age: 49.6±14.4 years; range, 18 to 87 years) diagnosed with AAV by experienced rheumatologists between July 2016 and May 2022 were included in this retrospective cross-sectional study and reclassified based on the 1990 ACR criteria, the European Medicines Agency (EMEA) algorithm, and the 2022 ACR/EULAR criteria. For external validation, 83 patients (48 males, 35 females; mean age: 47.3±17.5 years; range, 19 to 81 years) diagnosed with immunoglobulin (Ig)A vasculitis were included.
Results: One hundred twenty-six (76.8%) patients had granulomatosis with polyangiitis (GPA), 13 (7.9%) patients had eosinophilic granulomatosis with polyangiitis (EGPA), and 25 (15.2%) patients had microscopic polyangiitis (MPA). According to the criteria, the number of unclassified patients was nine (5.5%) for both the 2022 ACR/EULAR AAV classification criteria and the EMEA algorithm. The new criteria had an almost perfect agreement with the clinician's diagnosis (Cohen’s kappa coefficient [κ]=0.858 for GPA, κ=0.820 for EGPA, and κ=0.847 for MPA). The kappa statistics for agreement of 2022 ACR/EULAR classification criteria with the EMEA algorithm were found 0.794 for GPA, 0.820 for EGPA, and 0.700 for MPA. None of the 83 patients diagnosed with IgA vasculitis could be classified as GPA, EGPA, or MPA using the new ACR/EULAR AAV classification criteria.
Conclusion: The 2022 ACR/EULAR classification criteria for AAV showed substantial or perfect agreement with the clinical diagnosis and the EMEA algorithm.
The importance of speckle tracking echocardiography in the evaluation of cardiac functions in patients with rheumatoid arthritis
Authors: Ebik Müşerref , Taştekin Nurettin , Gürdoğan Muhammet , Ebik Mustafa , Birtane Murat , Emmungil Hakan , Yılmazer Barış , Süt Necdet 
Published: March 2024

Objectives: In this study, we aimed to analyze the layer-specific strain values obtained by speckle tracking echocardiography (STE) method in the determination of subclinical cardiac dysfunction in rheumatoid arthritis (RA) patients.
Patients and methods: Between February 2019 and October 2019, a total of 63 female RA patients (mean age: 51.82±6.07 years; range, 40 and 65 years) who had a confirmed diagnosis were included. Thirty-one age-matched female healthy individuals (mean age: 50.71±5.37 years; range, 40 and 65 years) were selected as the control group. The patients were divided into three groups according to the duration of disease as <5 years, 5-10 years and >10 years. The Disease Activity Score in 28 joint - C-reactive protein (CRP) was used to determine disease activation. The standard assessment included complete serum CRP, anti-cyclic citrullinated peptide, rheumatoid factor, N-terminal pro B-type natriuretic peptide (NT-proBNP), and homocysteine. Global longitudinal strain (GLS) analysis was performed with STE.
Results: The NT-proBNP values were found to be higher in RA patients compared to the control group (p=0.044). In terms of conventional echocardiographic parameters, a significant difference between E/A and E/E’ ratios was observed (p<0.001 and p=0.015). Endocardium, transmural, and epicardium GLS values obtained by STE were found to be lower in RA patients (p<0.05). The left ventricular (LV) GLS values worsened, as the duration of disease increased (p<0.05). There was a significant correlation between RA disease activity and LV GLS values, showing that increasing levels of disease activity was associated with worse LV GLS (r=0.583, p<0.01 and r=0.681, p<0.01 and r=0.689, p<0.01 for endocardium, transmural and epicardium, respectively).
Conclusion: Our study results suggest that the layer-specific GLS values obtained by STE decrease in RA patients.
COVID-19 vaccination rates and factors affecting vaccination in children with rheumatic disease
Authors: Aydın Tuncay , Özomay Baykal Gülcan , Karagöl Cüneyt , Haşlak Fatih , Oğultekin Vazgeçer Ebru , Torun Rüya , Kızıldağ Zehra , Kılıç Könte Elif , Aslan Esma , Güngörer Vildan , Çelikel Acar Banu , Sözeri Betül , Kasapçopur Özgür , Makay Balahan 
Published: March 2024

Objectives: This study aimed to investigate coronavirus disease 2019 (COVID-19) vaccination rates and factors affecting vaccination in children with rheumatic diseases.
Patients and methods: This multicenter cross-sectional survey-based study was conducted between July 2022 and September 2022. Four hundred seventy-four patients (256 females, 218 males; median age: 15 years; interquartile range, 13 to 16 years) were included in the patient group, and 211 healthy children (124 females, 87 males; median age: 15 years; interquartile range, 13 to 16 years) were included in the control group. A questionnaire was administered to the parents face-to-face during routine outpatient visits.
Results: Of the patients, 220 were followed up with the diagnosis of autoinflammatory disease, 174 with juvenile idiopathic arthritis, 48 with connective tissue disease, 23 with vasculitis, eight with uveitis, and one with sarcoidosis. In the study group, 256 (54%) patients and 115 (54.5%) healthy children received at least one dose of COVID-19 vaccine. Parents' concern regarding potential side effects of the vaccine was the most common reason for COVID-19 vaccination hesitancy in both groups. The median patient age, follow-up period, colchicine treatment rates, childhood vaccination and influenza vaccination rates, median parental age, parental vaccination rate, and parental education level were higher in vaccinated patients (p<0.001).
Conclusion: Parents' concerns about safety and side effects were found to be the most important factors affecting vaccination success. Identification of the underlying causes of parental vaccine hesitancy will facilitate the development of effective vaccination strategies for potential future outbreaks.
Biological treatment in elderly and young patients with ankylosing spondylitis: TURKBIO real-life data results
Authors: Uslu Sadettin , Gülle Semih , Urak Özkan , Şen Gerçek , Dalkılıç Ediz , Şenel Soner , Akar Servet , İnanç Nevsun , Cefle Ayşe , Köken Avşar Aydan , Yolbaş Servet , Yılmaz Sema , Soysal Gündüz Özgül , Sarı İsmail , Birlik Merih , Akkoç Nurullah , Önen Fatoş 
Published: March 2024

Objectives: This study aims to investigate the effect of age on disease activity and biological treatment in patients with ankylosing spondylitis (AS).
Patients and methods: A total of 811 AS patients registered in the TURKBIO registry database between 2011 and 2019 were categorized according to their age at the time of entry into the registry and assigned to one of two groups: young patients, defined as <60 years of age (n=610), and those aged ≥60 years (n=201) were recorded as elderly patients. Demographic, clinical, and laboratory characteristics, along with disease activity markers and other follow-up parameters, as well as current and prior treatments, were electronically recorded during each visit using open-source software.
Results: The mean age of the elderly patients was 67±5.8 years, while the mean age of the younger patients was 49.2±10.9 years. Male predominance was lower in the older AS group compared to the younger AS group (p=0.002). During follow-up period, 397 patients (comprising 318 young and 79 elderly individuals) had a history of using at least one biological disease-modifying agent (bDMARD). There was no significant difference between the groups in terms of DMARD and bDMARD-use distributions. First tumor necrosis factor inhibitor (TNFi) retention rates were found to be similar in both groups over 10 years of follow-up. Adverse events were found to be similar in young (19.9%) and elderly (26.8%) AS patients.
Conclusion: Research in the TURKBIO cohort reveals that both older and younger patients with AS exhibited similar disease activity levels with comparable treatment approaches. Moreover, the results of TNFi treatments in elderly patients were the same as those observed in younger patients, with no notable increase in safety concerns.
Early effectiveness and safety analysis of belimumab in addition to standard treatment in patients with systemic lupus erythematosus
Authors: He Lingyan , Yan Mingming , Wen Rui , Li Jiali 
Published: March 2024

Objectives: This study aimed to evaluate the early effectiveness and safety of belimumab in addition to standard therapy in patients with systemic lupus erythematosus (SLE) for 24 weeks.
Patients and methods: This retrospective study was conducted with 60 adult patients with active SLE between June 2020 and August 2022. The patients either received intravenous belimumab in addition to standard therapy (n=31; 24 females, 7 males; mean age: 33.7±14.1 years; range, 18 to 52 years) or only standard therapy (n=29; 22 females, 7 males; mean age: 34.1±13.4 years; range, 19 to 66 years) for 24 weeks. Outcome measures, including safety and effectiveness (Safety of Estrogens in Lupus Erythematosus National Assessment–Systemic Lupus Erythematosus Disease Activity Index [SELENA-SLEDAI]), changes in biomarkers (double-stranded DNA [deoxyribonucleic acid]), serum complement levels, and immunoglobin G (IgG) were recorded. Adverse events were recorded.
Results: Baseline demographic and clinical characteristics were similar between the two groups. More patients in the belimumab group achieved a reduction of ≥4 points in SELENA-SLEDAI at weeks 12 and 24 (week 12, 77.4% vs. 41.4%, p=0.008; week 24, 87.1% vs. 48.3%, p=0.002). The mean score of SELENA-SLEDAI was significantly lower in the belimumab group compared to the standard therapy group at week 12. However, a significant difference was not reached at week 24. Moreover, mean levels of serum C3 and C4 in the belimumab group were significantly higher than those in the standard therapy group at weeks 12 and 24. A higher proportion of patients in the belimumab group had a normal C3 level than in the standard therapy group. In addition, belimumab treatment resulted in a significant decrease in IgG levels at both weeks 12 and 24. At week 24, the belimumab group had a higher reduction in prednisone dose than the standard therapy group. Furthermore, the percentages of patients with more than 50% reduction in prednisone over baseline were significantly greater for belimumab versus standard therapy at week 12 (p=0.002). The occurrence of adverse events was similar between the two groups (standard therapy group, 44.8%; belimumab group, 51.6%).
Conclusion: Intravenous belimumab was well tolerated and significantly improved disease activity in Chinese patients with SLE at the early stage of treatment. More importantly, belimumab treatment could result in a rapid reduction in prednisone dose as early as week 12.
Fruit and Vegetable Waste Characteristics and Management Practices at Pasig Mega Market in Pasig City, Philippines
Authors: Buhion Ruth Paula , Barrion Aimee Sheree , Lanorio Ma. Cristina 
Published: March 2024

The fruit and vegetable sector produce waste significantly, causing social, environmental, and economic loss. Thus, a study was conducted at Pasig Mega Market, Pasig City to describe the fruit and vegetable vendors' waste management practices. Vendors and government employees participated in focus group discussions and key informant interviews. Results showed an average of 100-200 kilograms of waste were collected in the market daily, with leafy vegetables, watermelon, melon, and saba as common types. Focus group discussions revealed that discounted prices for suboptimal items, quality assurance methods, adherence to First-In-First-Out principles, and marketing strategies were the vendors' efforts to reduce waste. The identified approaches in handling wastes were, giving them as animal feed, creating alternative products, and returning damaged products to suppliers. Key informant interviews disclosed that the local government and market administration practices in waste management were composting and donation as animal feed for the local zoo. Moreover, it revealed improvement in the management of implementing the ordinances. Problems encountered were focused on supplier issues, weather, market competition, and consumer preferences. Overall, their waste management reduces food waste disposed of in landfills. Recommended strategies for vendors and administration are valorizing food waste, organizing awareness and livelihood programs, and conducting regular evaluations.
Effect of Gibberellic Acid (GA3) Concentration and Seedling Media Composition on the Germination and Growth of Shallots (Allium ascalonicum L.) from True Shallot Seed
Authors: Nurcharisma Adinda , Setiyono Setiyono , Sholikhah Ummi , Ratnasari Tri , Savitri Dyah Ayu , Patricia SM Susan Barbara , Arum Ayu Puspita , Novijanto Noer 
Published: March 2024

Shallots (Allium ascalonicum L.) is a vegetable commodity that contributes greatly to horticultural production and inflantion levels. The use of superior seeds is expected to produce maximum shallot production. The majority of Indonesian farmers use 30% of the harvested tubers as planting material, with production costs being quite expensive. Many shallot farmers also experience several problems with tuber seeds that are hollow and damaged. True Shallot Seeds can be an efficient and profitable altervative planting material. Implementing TSS shallot cultivation is considered difficult and requires longer time for sowing. Soaking seeds using Gibberelin can have a physiological effect on the germination process. Seedling media factor with a certain composition are needed to produce maximum seeds. The experiment was carried out in factorial manner using Random Design Complete with three replications. The GA3 concentration factor has four treatment levels: G0 = 0 ppm/control, G1 = 2 ppm, G2 = 4 ppm, and G3 = 6 ppm. The seedling media composition factors has four treatment levels: M0 = soil + compost/control (1:1), M1 = cocopeat + compost (1:1), M2 = husk charcoal + compost (1:1), and M3 = sand + compost (1:1). The data analysis used was Analysis of Variance, if there were significant differences between the treatments, a further tes was carried out using Duncan’s Multiple Range Test at the 5% level. The result showed that the interaction between GA3 concentration treatment and seedling media composition and the single factor GA3 concentration had no significant effect on all observed variables. The composition of the seedling media has a significant effect on the speed of seed growth, seed height, root length, and seed wet weight with optimum results for germination and vegetative growth of TSS seeds, namely the compositionof soil+compost/control (M0) seedling media on the variables of seed growth speed (%/etmal), seed height (cm), and seed wet weight (gram).
The influence of philosophical movements and artistic traditions of China on the fine arts of the Khitan Liao Empire
Authors: Хастуяа Л. , Уранчимэг Д. 
Published: March 2024

Статья посвящена ряду важных аспектов развития изобразительного искусства народа киданей, создавших в средние века государство, известное как империя Ляо. Находившееся на территории современной Монголии и Северного Китая, оно оказалось на пересечении различных культурных течений, в разной степени повлиявших на духовную жизни киданей и их творческую активность. Целью статьи является анализ процесса интенсивного взаимодействия киданей с китайской культурой, в результате чего на местной почве сложилась оригинальная художественная традиция, воспринявшая в мировоззренческом плане влияние даосизма, конфуцианства и буддизма. Ее искусствоведческий анализ позволяет сделать вывод об избирательном подходе киданьских художников к адаптации мотивов, стиля и изобразительного содержания, заимствованных из китайского искусства. Показано влияние конфуцианского учения, проявившееся в осознанном утверждении художественными средствами идей социального порядка, и воздействие буддизма, определившее характер мировосприятия художников и содействовавшее созданию разработанной иконографии. Обоснован вывод о том, что духовная культура и искусство народа киданей представляют собой уникальный синтез различных мировоззрений и художественных традиций.
The article discusses the development of fine arts among the Khitan people, who established the Liao Empire during the Middle Ages. The empire was located in modern-day Mongolia and Northern China, and was influenced by various cultural currents that impacted the spiritual life and creative activity of the Khitans to varying degrees. The article aims to analyse the process of intensive interaction between Khitans and Chinese culture, resulting in the formation of an original artistic tradition on local soil. This tradition was influenced by Taoism, Confucianism, and Buddhism in terms of world outlook. Analysis of this tradition allows us to conclude that Khitan artists took a selective approach to adapting motifs, style and visual content borrowed from Chinese art. The influence of Confucian teachings, manifested in the conscious affirmation of ideas of social order through artistic means, and the influence of Buddhism, which determined the nature of the artists’ world-view and contributed to the creation of the developed iconography, are shown. The conclusion is substantiated that the spiritual culture and art of the Khitan people represent a unique synthesis of different world-views and artistic traditions.