bluuebunny/crossref_metadata_2025_split huggingface dataset:
External validation of a multivariable prediction model for positive resection margins in breast-conserving surgery
Authors: Manhoobi Irina Palimaru , Ellbrant Julia , Bendahl Pär-Ola , Redsted Søren , Bodilsen Anne , Tramm Trine , Christiansen Peer , Rydén Lisa 
Published: April 2024

Abstract

Background: Positive resection margins after breast-conserving surgery (BCS) most often demands a repeat surgery. Identifying patients at risk of positive margins allow for surgical techniques using wider resection margins, which may reduce the need of additional surgeries.
A prediction model by Ellbrant et al. with seven preoperative clinical-pathological and imaging variables predicts positive margins after BCS with an area under the ROC curve (AUC) of 0.80.
The aim of the current study was to externally validate this prediction model and to explore if additional available preoperative variables can further improve the accuracy of the model.
Methods: This retrospective cohort study comprises 225 invasive breast cancer patients who underwent BCS and included at Aarhus University Hospital, Aarhus, Denmark during 2020-2022. Receiver operating characteristic (ROC) and calibration analysis were used to validate the multivariable prediction model. Univariable logistic regression was used to evaluate if additional variables available in the validation cohort were associated with positive margins and backward elimination to explore if these variables could further improve the model´s predictive accuracy.
Results: The AUC of the model was 0.60 (95% CI: 0.50-0.70) in the validation cohort.
High versus low mammographic breast density was associated with positive margins (p=0.009), however the AUC did not further increase, when adding this as an additional variable to the model. Conclusion: The accuracy of the model to predict positive margins after BCS in the validation cohort was lower as compared to in the development cohort, most likely due to differences in patient and tumor characteristics between the sites. High mammographic breast density was found to be associated with positive margins after BCS but did not further improve the model´s predictive accuracy.
Effects of sodium on A2A adenosine receptor expression and function: in cellulo approach and pathophysiological perspectives
Authors: Oufir Farid EL , Claire Guiol , Marlinge Marion , Kipson Nathalie , Criado Christine , Chaptal Marie C. , Lledo Simon , Dedoders Julia , Rebaoui Zohra , Fromonot Julien , Ruf Jean , Mottola Giovanna , Guieu Régis 
Published: April 2024

Abstract
The expression and function of G-protein coupled receptor is modulated by small molecules including sodium ion, acting at an allosteric site. Using Adonis, an Ig M monoclonal antibody against a linear epitope located in the second loop of the A2A adenosine receptor (A2AR) with agonist properties, we evaluate in cellulo the effects of different sodium ion concentrations on the expression and function of A2AR of peripheral blood mononuclear cells (PBMC). We found that high sodium ion concentration is associated with an increase in A2AR expression and a decrease in cAMP production evaluated by measuring the half-maximal cAMP production, (EC50), in a dose-dependent manner. When Adonis and sodium ions were added simultaneously in the culture medium, (competitive conditions), the KD and the EC50 were high compared to non-competitive conditions (mean 27 and 3 folds respectively). These results suggest that sodium ions could promote Adonis binding to A2AR as well as its activation. We hypothesize that, by steric hindrance, the binding of Adonis to A2AR extends beyond the orthostatic site and prevents sodium ion from reaching its allosteric pocket. When sodium ion can reach its site, it acts as an allosteric modulator with respect to A2AR expression and function. Because the action of sodium ions and A2A-R have opposite effects on blood pressure, our results highlight a possible role of A2A-R/sodium ions interaction in the regulation of blood pressure.
The chemokine receptor type 5 inhibitor maraviroc alleviates sepsis- associated liver injury by regulating MAPK/NF-κB signaling
Authors: Shao Jun , Wang Tianwei , Tang Chengbin , Yu Jiangquan , Chen Ying , Guo Xin , Wang Haoran , Zhou Lulu , Zhang Guozhong , Li Yuping , Yu Hailong , Zheng Ruiqiang 
Published: April 2024

Abstract

Purpose
Sepsis-related organ damage, as the most intractable problems in intensive care units(ICUs), receives a great deal of attention from healthcare professionals. Sepsis-associated liver injury (SALI) often leads to poor clinical outcomes due to its complex physiological mechanism. In previous studies, chemokine receptor 5 (CCR5) inhibitors were shown to exert unique anti-inflammatory effects. As the therapeutic effect of maraviroc (MVC) on SALI is still unclear, we aimed to explore whether MVC is effective in treating SALI.
Methods
We established a model of SALI by cecal ligation and puncture (CLP) and intraperitoneally injected 20 mg/kg MVC two hours after CLP. Results: The results showed that MVC could significantly ameliorate liver injury after CLP. Furthermore, we demonstrated that MVC reduced inflammatory infiltration and apoptosis after SALI. In addition, we found that the function of MVC in reducing inflammatory was obtained through the inhibition of the two inflammatory signaling pathways mentioned above. Finally, the JNK agonist AN was chosen for reverse research. As shown by the results, the therapeutic effects of MVC disappeared after AN treatment, indicating that MVC exerted anti-inflammatory and antiapoptotic effects through JNK.
Conclusion
Our study revealed that MVC could reduce liver injury after SALI by inhibiting liver inflammation and hepatocyte apoptosis induced by CLP and that MVC exerted diminish inflammatory effects by inhibiting theNF-κB and MAPK signaling pathways.
WITHDRAWN: Relationships Between Temperature and Precipitation Conditions and Tree- Ring Growth in Küre Mountains National Park in the Context of Climate Change
Authors: ATAY Selinay , İRDEM Cemil 
Published: April 2024

Abstract

This study aims to determine the effect of monthly average temperature and monthly total precipitation on tree ring growth and to reveal the possible effects of climate change by using gridded data from the lower and upper growing limits of Scots pine, fir and black pine in the Küre Mountains National Park. Küre Mountains National Park is an essential natural protected area in Türkiye's Black Sea Region. This park is one of the 9 Hotspots in Turkey. For dendrochronological analyses, samples were taken from the lower and upper growing limits of Scots pine, fir and black pine trees, using increment borer, from locations determined within the national park's borders. Measurements of the samples taken were made using the LINTABTSAP measurement system with a sensitivity of 0.01 mm. In analyzing climate-tree ring relations, gridded data taken from the World Meteorological Organization Regional Climate Center website was used for areal precipitation totals and temperature averages, as it has longer-term data. Response Functions were calculated with the help of DENDROCLIM2002 to reveal the statistical relationships between climate data and tree ring growth. According to our results, tree ring growth on trees in the research area is positively affected by the increases in monthly total precipitation in June and July for all site all chronologies and negatively affected by November of the previous year and January, February, September and October of the current year.
Exploring the impact of oral health on the quality of life in elderly patients: a cross-sectional study
Authors: Alshammary Nawaf 
Published: April 2024

Abstract

Objective: This aim was to investigate the significant impact of oral health on the quality of life of elderly individuals across various socioeconomic and demographic contexts.
Methods: A cross- sectional study was conducted, involving the distribution of a translated online questionnaire based on the OHQoL-UK®️ tool to evaluate oral health-related quality of life. This included utilizing the Oral Health Quality of Life Scale to assess overall quality of life. Internal reliability was assessed and Cronbach's Alpha reliability measures were determined.
Results: A total of 586 participants were involved in the study, with the majority being over 60 years old (77.1%). The mean score of Oral Health-Related Quality of Life OHRQoL was 3.79. The Social Dental Scale SDS had a mean score of 0.71. The General Oral Health Assessment GOHS scored 3.51 on average. The mean score of Dental Impact Profile DIP was 3.12. The Subjective Oral Health Status Indicators SOHSIs had a mean score of 3.82. The mean score of Oral Health Benefit of Life Inventory OHBLI averaged at 4.04, and DentalImpact on Daily Living DIDL scored an average of 4.05. The mean score of OHRQoL and Oral Impacts on Daily Performance OIDP were 3.90 and 3.89 respectively. Cronbach's Alpha values ranged from 0.854 to 0.939, with an overall questionnaire reliability of 0.977, indicting a good reliability of the study's tool.
Conclusion: Older adults exhibited lower oral health- related quality of life compared to younger adults, particularly influenced by factors such as health insurance coverage, monthly income and educational level. It is essential to develop health programs specifically tailored for senior adults to safeguard their overall health and quality of life. Making health and medical insurance obligatory and accessible to all individuals is crucial for enhancing their quality of life and reducing the prevalence of diseases.
The effect of combining primers and cements from different cement systems on the bond strength between zirconia and dentin
Authors: Le Minh , Papia Evaggelia , Larsson Christel 
Published: April 2024

Abstract

Objective: The aim of this study was to evaluate the influence of combining primers and cements from two different resin cement systems on the microtensile bond strength (μTBS) between zirconia and human dentin.
Materials and methods: A total of 120 specimens of zirconia cemented to dentin were allocated into eight groups based on cement type (RelyX Ultimate or Panavia V5) and primers (Tooth Primer, Clearfil Ceramic Primer and Scotchbond Universal Adhesive) combinations, applied to dentin or ceramic surfaces. Following artificial aging with 5000 thermocycles, μTBS tests were conducted. Statistical analysis was performed using One-way ANOVA and Tukey’s post hoc tests (p≤ .05), and failure modes were assessed.
Results: The Panavia cement systems demonstrated the highest bond strength (19.4 ± 4.4 MPa), significantly higher than the other groups except when RelyX cement was used with Panavia primers (16.9 ± 3.7 MPa). Cohesive fractures at the cement layer were the predominant failure mode.
Conclusions: The combination of primers from different adhesive cement system brands may significantly affects the bonding effectiveness. Therefore, using products from a single product line of the same adhesive cement system, and following the manufacturer's recommendations for indications and use, is crucial for a more predictable clinical outcome.
Placental mesenchymal dysplasia: a rare case associated with second trimester fetal growth restriction
Authors: Chadwick Thomas , Davis Jennifer , Bitar Wafa , Pankaja Susmita 
Published: April 2024

Abstract

Background: Placental mesenchymal dysplasia (PMD) is a rare, benign, placental disorder characterised macroscopically by an enlarged multi-cystic placenta. It is a condition associated with a range of reported clinical outcomes and can be misdiagnosed as a molar or partial molar pregnancy given the similarities in clinical presentation. We present an unusual case of PMD complicated by fetal growth restriction and oligohydramnios in the second trimester.
Case presentation: A 33 year old female was referred to our fetal medicine unit with a multi-cystic placenta at dating scan suspected initially to be a partial molar pregnancy. She opted for conservative management and declined invasive testing. At 16 weeks severe fetal growth restriction was present with an estimated fetal weight <3rd centile and associated with oligohydramnios. Whilst live births in cases of PMD have been reported in the literature, to our knowledge there are no reported successful outcomes in cases of early onset growth restriction at this gestation. The patient opted to proceed with termination of pregnancy given the suspected poor prognosis. Post mortem results confirmed a diagnosis of PMD and fetal growth restriction with normal genetic testing.
Conclusions: Placental mesenchymal dysplasia can be a difficult condition to manage, particularly when counselling about prognosis and deciding whether to continue the pregnancy. More evidence is needed about prognostic factors in PMD associated with a successful outcome. Early onset fetal growth restriction and/or oligohydramnios prior to 20 weeks are likely poor prognostic factors which should be considered in the antenatal counselling.
Pleomorphic Adenoma of the Palate: Navigating Radiologic and Histologic Terrain – A Case Report Demonstrating Comprehensive Clinical Understanding and Management
Authors: Kajla Paramjit , Gowda Sharad , K Sri Sudarsan P 
Published: April 2024

Abstract
Background:- Pleomorphic adenoma can be defined as a benign mixed tumor composed of epithelial and myoepithelial cells arranged with a great histological diversity, such as differentiation into oncocytic, sebaceous, mucinous, squamous, chondroid, osseous or adipose cells demarcated from surrounding tissues by fibrous capsule. It is one of the salivary gland tumors affecting both major and minor salivary glands. Parotid gland is the most commonly affected of the major group. Among minor salivary glands, palate is the most common site intraorally. Often confused with other malignant tumours of salivary gland, systematic approach rather than aggressive treatment reduces patient morbidity and gives best results as in our case.
Case presentation:- Here we present a case report of pleomorphic adenoma of minor salivary gland of hard palate of a young female. Treatment was surgical excision with wide margins which was confirmed by a histopathological report. Surgical obturator was used to close the defect and monthly follow-up for 6 months to assess the healing and recurrence of the tumour.
Conclusion:- Simple systematic treatment approaches often gives best results with follow up of the patient. In this case, complete resolution of the tumour following simple excision and regular follow up.
The data from sightings suggest a causal correspondence between the distribution of survey effort and the distribution of whales in the Gulf of California
Authors: Castañeda Omar Garcia , Lobo Jorge M. , R Jorge Urbán , Pelayo-González Lili , Unzueta Alejandro Gómez-Gallardo 
Published: April 2024

Abstract

Data on the distribution of most species are often collected using non-standardized sampling protocols, resulting in biased data due to preferential selection of certain environmental conditions. This study aimed to assess the distribution of survey effort for whale monitoring in the Gulf of California, México and estimate its correlation with environmental variables at different resolutions. This comprehensive database compiles navigation details and species observations from 1982 to 2018. The number of navigation routes for whale monitoring in the Gulf of California was calculated, and 10% and 5% of the best-surveyed cells were located at five different resolutions. Generalized Linear Models were employed to estimate the explanatory capacity of eight environmental variables in the distribution of the survey effort. Only approximately 3%-10% of the entire area can be considered well-surveyed. Collection effort was highest in areas with cold waters, high levels of particulate organic carbon, and phytoplankton, irrespective of resolution. However, regardless of environmental conditions, the distribution of survey efforts correlated with available data on the distribution of whales. These results suggest that the knowledge and prolonged interaction between data collectors and the whale population mainly influence the heterogeneous distribution of survey effort. Understanding biases and associated factors in survey effort distribution may provide insights for future monitoring programs. This knowledge can inform effective conservation strategies for whales in the Gulf of California and beyond.
Analysis of the correlation between sex and excessive daytime sleepiness in stroke patients
Authors: Zheng Yi-Xi , Sun Shu-Tong , Yu Wen-Yi , Xu Li-Wen , Liu Ruo-Nan , Chu Cheng 
Published: April 2024

Abstract

Background
Excessive daytime sleepiness (EDS) is a common complication of stroke that has a detrimental effect on patients' daily life and functional recovery.The clinical and sleep-related factors of poststroke EDS may differ between males and females.
Methods
Stroke patients who participated in polysomnographic monitoring at Affiliated Hospital of Yangzhou University from February 2022 to September 2023 were included, and baseline data, laboratory tests, polysomnographic data, and related scale scores were retrospectively collected. The ESS (Epworth Sleepiness Scale) score and sex were used as the basis for grouping, and statistical analysis was performed using SPSS 26.0.
Results
Compared with females with EDS, female patients without EDS had lower white blood cell counts (p = 0.029); male patients with EDS had higher creatinine values than did those without EDS (p = 0.009); female patients with EDS had higher PSQI scores than did females without EDS vs. did males with EDS (p = 0.007; p = 0.034); and both male and female patients with EDS had poorer subjective sleep quality; and both male and female patients with EDS had higher daytime dysfunction scores than did those without EDS (p < 0.001); among female patients, depression scores (HADS-D) were greater in the EDS group than in the no-EDS group (p = 0.004); women with EDS had longer sleep latency (p = 0.002) and a shorter percentage of N2 sleep periods (p = 0.027) than did men with EDS did; Spearman correlation analysis related to ESS scores revealed a significant positive correlation between HADS-D scores and ESS scores in female patients (p = 0.001); and daytime dysfunction scores were significantly positively correlated with ESS scores in both male and female patients. (p < 0.001; p = 0.001).
Conclusions
Female patients suffering from daytime sleepiness have poorer sleep quality and more disturbed sleep architecture. Targeted development of different interventions is necessary, especially focusing on the psychological and sleep problems of female patients, and may further advance the treatment and prognosis of female stroke patients.
Pre-Service Teachers‘ Approaches in Solving Mathematics Tasks with ChatGPT – A Qualitative Analysis of the Current Status Quo
Authors: Noster Norbert , Gerber Sebastian , Siller Hans-Stefan 
Published: April 2024

Abstract

This study investigates pre-service teachers’ competence in using large language models in mathematical contexts and with that the ability to evaluate answers provided by the chatbot. This is of interest as due to its probabilistic nature the answers cannot be foreseen while bearing the risk of being erroneous although sounding plausible. Eleven pre-service teachers were asked to solve four different tasks with the help of ChatGPT. The chatlogs and information provided in an interview after working on the tasks are analyzed using qualitative content analysis. Results show that both correct and incorrect answers were produced for all tasks. The rate of pre-service teacher providing an incorrect answer is high when having been presented an incorrect answer generated by the large language model. Despite having access to ChatGPT as a tool many of the participants were not able to live up to their self-evaluated mathematical skill and had trouble solving more complex problems. Furthermore, prompting techniques are analyzed and found to have a great variety while seemingly being dependent on the task as a context. Therefore, the focus of future research should lie on the user’s competence as well as the context the model is used in.
Effects of Radio Frequency Roasting and Pressing Techniques on Peanut Oil Quality and Aroma
Authors: Hung Chun-Hsiang , Chen Su-Der 
Published: April 2024

Abstract

Peanuts undergo roasting to develop a distinctive aroma before undergoing controlled temperature pressing for peanut oil extraction. This study utilized 100°C hot air-assisted 5 kW radio frequency (HARF) equipment for peanut roasting. Subsequently, peanut oil extraction was conducted through cold pressing (CP) at 60°C and hot pressing (HP) at 120°C, with a comprehensive evaluation of their qualities and aromas. Analysis revealed that the surface temperatures of roasted peanuts were lower than their center temperatures, with center temperatures ranging from 120.6°C to 167.6°C for RF roasting durations of 4.5 to 10.5 min. As RF roasting time increased, acidity value, peroxide value, and malondialdehyde content significantly rose, reaching maximum values after 10.5 min, which evident charring on the peanut surface rendered them unsuitable for oil extraction. Aroma analysis via GC-IMS showed that peanuts roasted for 8.5 min exhibited volatile compounds similar to those found in commercial peanuts. Comparatively, 120°C HP yielded more oil than 60°C CP. Furthermore, GC-IMS analysis indicated that HP peanut oil contained more volatile compounds, contributing to a burnt odor and Maillard reaction, affecting both color and oxidation levels. Accelerated storage experiments at 65°C for duration of 24 days demonstrated a continuous increase in both acidity and peroxide values throughout the storage period."
GIS-MCDM Integrated approach for suitable landfill site selection: Case study of the southwestern part of Bejaia Province, Algeria
Authors: Bechroune Wissam , Kherrour Louardi , Belaid Lyes , Goumrasa Abdeldjalil 
Published: April 2024

Abstract
Household waste management in developing countries is a major concern, from production to final disposal, so siting a landfill is a difficult and complex process, requiring the assessment of many factors. In this study, an integrated approach combining Geographic Information System (GIS) and Analytic Hierarchy Process (AHP) was used to select optimal sites for the implementation of a landfill in the south-eastern region of the Bejaia Province. This analysis is based on fourteen factors from different sources, including geomorphological, hydrological, climatic and socio-economic criteria. These spatial data are processed and analyzed in a GIS environment, while the AHP approach has been used to evaluate the importance of each factor in order to determine the weight and combine the selected factors. Finally, a suitability map was prepared by overlay analysis, indicating that the study area is divided into four suitability classes, with areas classified as unsuitable and low suitable representing 4.484% and 28.26% respectively, while 60% is considered moderately suitable and only 0.49% is highly suitable for the construction of a landfill. Based on these results, four potential sites were identified out of a total of thirteen. However, this study underlines the need to take into account social-economic and environmental aspects in the decision-making process to ensure efficient and durable waste management.