bluuebunny/crossref_metadata_2025_split huggingface dataset:
Uncoupling protein 2 polymorphisms as risk factors for NTDs
Authors: Mitchell Adam , Pangilinan Faith , Van der Meer Julie , Molloy Anne M. , Troendle James , Conley Mary , Kirke Peadar N. , Scott John M. , Brody Lawrence C. , Mills James L. 
Published: January 2009

AbstractBACKGROUND: Both environmental and genetic factors are involved in the etiology of NTDs. Inadequate folate intake and obesity are important environmental risk factors. Several folate‐related genetic variants have been identified as risk factors; however, little is known about how genetic variants relate to the increased risk seen in obese women. Uncoupling Protein 2 (UCP2) is an attractive candidate to screen for NTD risk because of its possible role in obesity as well as energy metabolism, type‐2 diabetes, and the regulation of reactive oxygen species. Interestingly, a previous study found that a common UCP2 compound homozygous genotype was associated with a threefold increase in NTD risk. METHODS: We evaluated three polymorphisms, ‐866G>A, A55V, and the 3′UTR 45 bp insertion/deletion, as risk factors for NTDs in Irish NTD cases (n = 169), their mothers (n = 163), their fathers (n = 167), and normal control subjects (n = 332). RESULTS: Allele and genotype frequencies were not significantly different when comparing NTD mothers, NTD fathers, or affected children to controls. Additionally, the previously reported risk genotype (combined homozygosity of 55VV and 3′UTR 45 bp deletion/deletion) was not present at a higher frequency in any NTD group when compared to controls. CONCLUSIONS: In our Irish study population, UCP2 polymorphisms did not influence NTD risk. Moreover, the prevalence of this allele in other populations was similar to the Irish prevalence but far lower than reported in the previous NTD study, suggesting that this previous finding of an association with NTDs might have been due to an unrepresentative study sample. Birth Defects Research (Part A), 2009. © 2009 Wiley‐Liss, Inc.
Ljungan virus present in intrauterine fetal death diagnosed by both immunohistochemistry and PCR
Authors: Samsioe Annika , Papadogiannakis Nikos , Hultman Thomas , Sjöholm Åke , Klitz William , Niklasson Bo 
Published: January 2009

AbstractOBJECTIVES: Following up on prior evidence from animal and human studies of Ljungan virus (LV) in intrauterine fetal death (IUFD), we examine additional cases of IUFD using two standard assays of viral detection: immunohistochemistry (IHC) and real time RT‐PCR. MATERIALS AND METHODS: Frozen and formalin‐fixed specimens from IUFD cases were tested for the presence of LV using real time RT‐PCR and IHC, respectively. Formalin‐fixed organs from terminated pregnancies diagnosed as trisomy 21 were used as controls in the IHC assay. RESULTS: Presence of LV was demonstrated in all five IUFD cases by IHC and further confirmed in three of these cases by real time RT‐PCR. Only one of 18 trisomy 21 controls was LV positive by IHC. CONCLUSION: The presence of LV in IUFD patients has been confirmed by two different assays. Birth Defects Research (Part A), 2009. © 2009 Wiley‐Liss, Inc.
“Setting paint” analogy for the hydrophobic self‐association of tropoelastin into elastin‐like hydrogel
Authors: Naumann Christoph , Mithieux Suzanne M. , Szekely David , Tu Yidong , Weiss Anthony S. , Kuchel Philip W. 
Published: January 2009

AbstractAlkaline tropoelastin solutions (pH 11) were optically clear at low temperatures, but a firm gel formed when the temperature was raised to 37°C. Reversion to a clear solution took place if the temperature was lowered to below 20°C within less than 2 h, but not if 37°C was maintained for several hours. The precipitated elastin‐like hydrogel thus formed did not visually redissolve at low temperatures. Tropoelastin hydrogel was stable to subsequent washings with alkaline solution at 37°C, but at 4°C some hydrogel redissolved showing that association is at least partly reversible. Washing the hydrogel with neutral 8M urea solution at 4°C dissolved less than 10% of tropoelastin in 24 h. We characterized this phenomenon by combining temperature‐controlled light microscopy analysis, 1H NMR spectroscopy (temperature, diffusion, and relaxation time studies), and UV‐absorption‐based concentration measurements. The self‐association of tropoelastin at pH 11 is due to hydrophobic interactions in an emulsion‐like system in which the spherules coalesce in a manner like a water‐based latex paint that forms a durable hydrophobic sheet as water and the organic solvent evaporate. In the present case, the sedimentation and entanglement of the tropoelastin porous sheets means that reverse dissolution is a kinetically slow process. © 2009 Wiley Periodicals, Inc. Biopolymers 91: 321–330, 2009.This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com
Molecular dynamics simulations of xDNA
Authors: Varghese Mathew K. , Thomas Renjith , Unnikrishnan N. V. , Sudarsanakumar C. 
Published: January 2009

AbstractxDNA is a modified DNA, which contains natural as well as expanded bases. Expanded bases are generated by the addition of a benzene spacer to the natural bases. A set of AMBER force‐field parameters were derived for the expanded bases and the structural dynamics of the xDNA decamer (xT5′ G xT A xC xG C xA xG T3′) · (xA5′ C T xG C G xT A xC A3′) was explored using a 22 ns molecular dynamics simulation in explicit solvent. During the simulation, the duplex retained its Watson‐Crick base‐pairing and double helical structure, with deviations from the starting B‐form geometry towards A‐form; the deviations are mainly in the backbone torsion angles and in the helical parameters. The sugar pucker of the residues were distributed among a variety of modes; C2′ endo, C1′ exo, O4′ endo, C4′ exo, C2′ exo, and C3′ endo. The enhanced stacking interactions on account of the modification in the bases could help to retain the duplex nature of the helix with minor deviations from the ideal geometry. In our simulation, the xDNA showed a reduced minor groove width and an enlarged major groove width in comparison with the NMR structure. Both the grooves are larger than that of standard B‐DNA, but major groove width is larger than that of A‐DNA with almost equal minor groove width. The enlarged groove widths and the possibility of additional hydration in the grooves makes xDNA a potential molecule for various applications. © 2009 Wiley Periodicals, Inc. Biopolymers 91: 351–360, 2009.This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com
High‐resolution structures of collagen‐like peptides [(Pro‐Pro‐Gly)4‐Xaa‐Yaa‐Gly‐(Pro‐Pro‐Gly)4]: Implications for triple‐helix hydration and Hyp(X) puckering
Authors: Okuyama Kenji , Hongo Chizuru , Wu Guanghan , Mizuno Kazunori , Noguchi Keiichi , Ebisuzaki Shutoku , Tanaka Yuji , Nishino Norikazu , Bächinger Hans Peter 
Published: January 2009

AbstractStructures of (Pro‐Pro‐Gly)4‐Xaa‐Yaa‐Gly‐(Pro‐Pro‐Gly)4 (ppg9‐XYG) where (Xaa, Yaa) = (Pro, Hyp), (Hyp, Pro) or (Hyp, Hyp) were analyzed at high resolution using synchrotron radiation. Molecular and crystal structures of these peptides are very similar to those of the (Pro‐Pro‐Gly)9 peptide. The results obtained in this study, together with those obtained from related compounds, indicated the puckering propensity of the Hyp in the X position: (1) Hyp(X) residues involved in the Hyp(X):Pro(Y) stacking pairs prefer the down‐puckering conformation, as in ppg9‐OPG, and ppg9‐OOG; (2) Hyp(X) residues involved in the Hyp(X):Hyp(Y) stacking pairs prefer the up‐puckering conformation if there is no specific reason to adopt the down‐puckering conformation. Water molecules in these peptide crystals are classified into two groups, the 1st and 2nd hydration waters. Water molecules in the 1st hydration group have direct hydrogen bonds with peptide oxygen atoms, whereas those in the 2nd hydration group do not. Compared with globular proteins, the number of water molecules in the 2nd hydration shell of the ppg9‐XYG peptides is very large, likely due to the unique rod‐like molecular structure of collagen model peptides. In the collagen helix, the amino acid residues in the X and Y positions must protrude outside of the triple helix, which forces even the hydrophobic side chains, such as Pro, to be exposed to the surrounding water molecules. Therefore, most of the waters in the 2nd hydration shell are covering hydrophobic Pro side chains by forming clathrate structures. © 2009 Wiley Periodicals, Inc. Biopolymers 91: 361–372, 2009.This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com
A review of the current state of biodiesel production using enzymatic transesterification
Authors: Fjerbaek Lene , Christensen Knud V. , Norddahl Birgir 
Published: January 2009

AbstractEnzymatic biodiesel production has been investigated intensively, but is presently employed industrially only in a 20,000 tons/year pilot plant in China (Du et al. [2008] Appl Microbiol Technol 79(3):331–337). This review presents a critical analysis of the current status of research in this area and accentuates the main obstacles to the widespread use of enzymes for commercial biodiesel transesterification. Improved results for enzymatic catalysis are seen with respect to increased yield, reaction time and stability, but the performance and price of the enzymes need further advances for them to become attractive industrially for biodiesel production. Critical aspects such as mass transfer limitations, use of solvents and water activity are discussed together with process considerations and evaluation of possible reactor configurations, if industrial production with enzymes is to be carried out. Results of published studies on the productivity of enzymes are also presented and compared to the use of chemical catalysts. Biotechnol. Bioeng. 2009;102: 1298–1315. © 2009 Wiley Periodicals, Inc.
Formation of cyclodextrins with cyclodextrin glucosyltransferase stimulated with polarized light
Authors: Fiedorowicz Maciej , Khachatryan Gohar , Konieczna–Molenda Anna , Tomasik Piotr 
Published: January 2009

AbstractAfter illumination with white, linearly polarized light (WLPL), cyclodextrin glycosyltransferase produced mixture of α‐, β‐, and γ‐cyclodextrins (CD) with higher overall yield than did that enzyme when nonilluminated. The illumination also influenced the ratio of those CD and that effect depended on concentration of enzyme and illumination time. At a high enzyme concentration (0.64 U/cm3), regardless the illumination time, formation of β‐CD predominated. The highest yield of β‐CD was afforded after 1 h illumination and 2 h illumination led to a significant increase in the yield of γ‐CD. Three‐month storage of enzyme illuminated with WLPL did not reduce its enhanced activity. © 2009 American Institute of Chemical Engineers Biotechnol. Prog., 2009
Anticoagulation with the direct thrombin inhibitor argatroban in patients presenting with acute coronary syndromes
Authors: Yeh Robert W. , Baron Suzanne J. , Healy Joanne L. , Pomerantsev Eugene , McNulty Iris A. , Cruz‐Gonzalez Ignacio , Jang Ik‐Kyung 
Published: January 2009

AbstractObjectives:This study examined the efficacy and safety of the direct thrombin inhibitor argatroban in patients presenting with acute coronary syndromes undergoing cardiac catheterization.Background:Argatroban is a direct‐thrombin inhibitor approved for use in percutaneous coronary intervention in patients with heparin‐induced thrombocytopenia. Few studies have examined its use in patients undergoing cardiac catheterization for acute coronary syndromes. We performed a retrospective cohort study of patients presenting with acute coronary syndromes who received argatroban anticoagulation during cardiac catheterization.Methods:Consecutive patients presenting with acute coronary syndromes who received argatroban while undergoing cardiac catheterization from 2002 to 2005 were included. Patient characteristics and in‐hospital outcomes were examined retrospectively via detailed chart review. The primary endpoints of the study were combined death, myocardial infarction or urgent revascularization, and major bleeding during the index hospitalization.Results:A total of 144 patients presenting with an acute coronary syndrome received argatroban during cardiac catheterization within the study period: 25% presented with ST‐elevation myocardial infarction and 75% presented with non‐ST‐elevation acute coronary syndrome. The combined endpoint of death, myocardial infarction or urgent revascularization occurred in 13.2% of patients during the hospitalization. Major bleeding occurred in 2.1% of patients.Conclusions:In this cohort of patients presenting with acute coronary syndromes, patients receiving argatroban during cardiac catheterization had a moderate rate of adverse cardiac events and a very low rate of major bleeding. © 2009 Wiley‐Liss, Inc.
Chronically anticoagulated patients who need surgery: Can low‐molecular‐weight heparins really be used to “bridge” patients instead of intravenous unfractionated heparin?
Authors: Jaff Michael R. 
Published: January 2009

AbstractPatients at high risk of arterial or venous thromboembolic events often receive chronic treatment with long‐term oral anticoagulants such as warfarin. However, if these patients require an invasive procedure, they may require a temporary interruption of their warfarin therapy to minimize their bleeding risk during the procedure. As warfarin has a long half‐life and an unpredictable pharmacokinetic profile, short‐acting parenteral anticoagulants, such as unfractionated heparin (UFH) and low‐molecular‐weight heparin (LMWH), may be of benefit in protecting the patient from thromboemboli while their warfarin dose is withheld. Such “bridging therapy” has traditionally been provided in‐hospital with intravenous UFH; however, recent data have suggested that LMWH may be an effective alternative, with potential cost‐savings due to the ability to provide bridging therapy in the outpatient setting. © 2009 Wiley‐Liss, Inc.
ChemInform Abstract: Structure Refinement of Lu2WO6 and Luminescent Properties of Eu3+, Pr3+ Doped Lu2WO6.
Authors: Zhang Zhijun , Zhang Hui , Duan Chengjun , Yuan Junlin , Wang Xiaojun , Xiong Dingbang , Chen Haohong , Zhao Jingtai 
Published: January 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Syntheses, Crystal Structures and Si Solubilities of New Layered Carbides Zr2Al4C5 and Zr3Al4C6.
Authors: Sugiura Keita , Iwata Tomoyuki , Yoshida Hideto , Hashimoto Shinobu , Fukuda Koichiro 
Published: January 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Anomalous Low‐Temperature Behavior of the Co Dimers in the Oxo‐halide CoSb2O3Br2.
Authors: Hugonin Zuzana , Johnsson Mats , Lidin Sven , Wulferding Dirk , Lemmens Peter , Kremer Reinhard K. 
Published: January 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Iodoalkoxylation, Iodohydroxylation, and Iodoacetoxylation of Alkenes Catalyzed by CdCl2×2.5H2O.
Authors: Mekhtieva V. Z. , Karaev S. F. 
Published: January 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Highly Reactive and Enantioselective Bifunctional Organocatalyst for the Methanolytic Desymmetrization of Cyclic Anhydrides: Prevention of Catalyst Aggregation.
Authors: Oh Sang Ho , Rho Ho Sik , Lee Ji Woong , Lee Je Eun , Youk Sung Hoon , Chin Jik , Song Choong Eui 
Published: January 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Formation of N‐Acyl‐N,N′‐dicyclohexylureas from DCC and Arenecarboxylic Acids in the Presence of Hydroxybenzotriazole in CH2Cl2 at Room Temperature.
Authors: Kaiser Carlos R. , Pinheiro Alessandra C. , De Souza Marcus V. N. , Wardell James L. , Wardell Solange M. S. V. 
Published: January 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Oxidative Bromination of Aromatic Compounds Using O‐Iodoxybenzoic Acid with Tetraethylammonium Bromide.
Authors: Bhalerao Dinesh S. , Mahajan Ulhas S. , Akamanchi Krishnacharya G. 
Published: January 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: K7[PW11CoO40]: Efficient and Ecofriendly Catalyst for the Enamination of β‐Dicarbonyl Compounds.
Authors: Oskooie Hossein A. , Heravi Majid M. , Javadi Negar M. , Bakhtiari Khadijeh , Bamoharram Fatemeh F. 
Published: January 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Novel DNA‐Catalyzed Aldol Reaction.
Authors: Sun Gaojun , Fan Jinmin , Wang Zhiyong , Li Yingfu 
Published: January 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Microwave‐Assisted Efficient Methylation of Alkyl and Arenesulfonamides with Trimethylsulfoxonium Iodide and KOH.
Authors: Malik Sarika , Nadir Upender K. , Pandey Pramod S. 
Published: January 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Palladium‐Catalyzed Carbon—Sulfur Cross‐Coupling Reactions with Indium Tri(organothiolate) and Its Application to Sequential One‐Pot Processes.
Authors: Lee Jae‐Young , Lee Phil Ho 
Published: January 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Cycloaddition of Cyclohexa‐2,4‐dienones with Nitroolefins: An Unusual Regioselectivity and Expeditious Entry into Nitro‐bicyclo[2.2.2]octenones.
Authors: Singh Vishwakarma , Singh Raj Bahadur , Tosh Dilip K. , Mobin Shaikh M. 
Published: January 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Unmatched Efficiency and Selectivity in the Epoxidation of Olefins with oxo‐Diperoxomolybdenum(VI) Complexes as Catalysts and Hydrogen Peroxide as Terminal Oxidant.
Authors: Maiti Swarup K. , Dinda Subhajit , Bhattacharyya Ramgopal 
Published: January 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Organocatalytic Asymmetric 1,4‐Addition of Organoboronic Acids to γ‐Hydroxy α,β‐Unsaturated Aldehyde: Facile Synthesis of Chiral β‐Substituted γ‐Lactones.
Authors: Kim Sung‐Gon 
Published: January 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Palladium‐Catalyzed Direct C‐2 Arylation of Indoles with Potassium Aryltrifluoroborate Salts.
Authors: Zhao Jinlong , Zhang Yuhong , Cheng Kai 
Published: January 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Conformationally Constrained Adamantane Imidazolines with Trypanocidal Activity.
Authors: Papanastasiou Ioannis , Tsotinis Andrew , Foscolos George B. , Prathalingam S. Radhika , Kelly John M. 
Published: January 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Simple and Mild Procedures for Synthesis of Benzimidazole Derivatives Using Heterogeneous Catalyst Systems.
Authors: Sharghi Hashem , Asemani Omid , Tabaei Seyed Mohamad Hossein 
Published: January 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.