bluuebunny/crossref_metadata_2025_split huggingface dataset:
Family Talk versus usual services in improving child and family psychosocial functioning in families with parental mental illness: a randomised controlled trial and cost analysis
Authors: Furlong Mairead , McGuinness Colm , Mulligan Christine Marie , McGarr Sharon Lisa , McGilloway Sinead 
Published: March 2024

BackgroundParental mental illness (PMI) is common and places children at high risk of developing psychological disorders. Family Talk (FT) is a well-known, whole-family, 7-session intervention designed to reduce the risk of transgenerational psychopathology. However, very few larger-scale evaluations of FT (across only a limited number of settings) have been conducted to date while there have been no cost analyses. This study aimed to assess the effectiveness and costs of delivering FT in improving child and family psychosocial functioning in families with PMI within routine mental health settings.MethodsA total of 83 families with PMI, with children aged 5-18 years, were randomly assigned on a 2:1 ratio to receive either the FT intervention (n=55 families) or usual services (n=28 families) across 10 adult, child and primary care mental health sites in Ireland. Parental disorders included anxiety/depression (57%), Bipolar Disorder (20%), Borderline Personality Disorder (12%), Post-Traumatic Stress Disorder (8%) and psychosis (2%). Detailed assessments with parents were conducted at baseline and 6-month follow up.ResultsFT led to significant improvements in family functioning and child behaviour at 6-month follow up when compared to usual services, with medium effect sizes indicated. Parent participants with lower mental health literacy at baseline also showed significant post-intervention improvements. Those parents with less severe mental illness at baseline, and families with more partner and economic supports, reported additional significant post-intervention improvements in child depression/anxiety and parental mental health symptoms. The cost of FT amounted to €761.50 per family, although this decreased to €415.31 when recurring costs only were included.ConclusionThe findings from this study, which was conducted within the context of a national programme to introduce family-focused practice in Ireland, demonstrate that FT is a low-cost intervention that improved child and family psychosocial functioning across different mental health disorders within routine adult, child and primary care mental health services. The findings contribute to the growing evidence base for FT, and provide a robust basis to inform practice and policy development for families with parental mental illness both in Ireland and elsewhere.Clinical trial registrationhttps://www.isrctn.com/ISRCTN13365858, identifier ISRCTN13365858.
The patient journey project in Italian mental health services: results from a co-designed survey on clinical interventions and current barriers to improve the care of people living with schizophrenia
Authors: Vita Antonio , Barlati Stefano , Porcellana Matteo , Sala Elisa , Lisoni Jacopo , Brogonzoli Luisa , Percudani Mauro Emilio , Iardino Rosaria 
Published: March 2024

IntroductionThe Patient Journey Project aimed to analyze the scenario among Italian Mental Health Services (MHS) to understand the clinical interventions that are properly implemented and the ones deserving further implementation to design an effective treatment plan for patients living with schizophrenia (PLWS).MethodsThe 60-items survey was co-designed with all the stakeholders (clinicians, expert patients and caregivers) involved in the Patient Journey and focused on three phases of schizophrenia course: early detection and management, acute phase management, long-term management/continuity of care. Respondents were Heads of the Mental Health Departments and Addiction Services (MHDAS) or facilities directors throughout Italian MHS. For each statement, respondents expressed the consensus on the importance and the degree of implementation in clinical practice.ResultsConsidering the importance of the statement, strong consensus was reached for most of the statements. Good levels of implementation were found on 2/17 statements of early detection and management, on 3/16 statements for acute phase management and on 1/27 statements of long-term management/continuity of care. Poor levels of implementation were found on 1/17 statements of early detection and management, none of acute phase management, and 4/27 statements for long-term management/continuity of care. Moderate levels of implementation were found on 14/17 statements for early detection and management, on 13/16 statements of acute phase management, and on 22/27 statements of long-term management/continuity of care. Thus, among Italian MHDAS, most interventions for PLWS were moderately implemented in clinical practice.DiscussionItalian MHS have to provide new strategies and structural actions to overcome these current limitations and barriers to effectively improve the journey of PLWS. The areas that deserve most implementation include interventions during the early stage (especially the continuity of care between Child and Adolescent Mental Health Services and Adult Mental Health Services), the evidence-based psychosocial interventions during the chronic stages of the disorder, and the continuity of care after acute hospitalization.
Physical activity improves the visual–spatial working memory of individuals with mild cognitive impairment or Alzheimer’s disease: a systematic review and network meta-analysis
Authors: Deng Jie , Wang Hong , Fu Tingting , Xu Chong , Zhu Qiqi , Guo Liya , Zhu Yu 
Published: March 2024

ObjectiveOur network meta-analysis aimed to ascertain the effect of physical activity on the visual–spatial working memory of individuals with mild cognitive impairment and Alzheimer’s disease as well as to propose tailored exercise interventions for each group.MethodsEmploying a frequentist approach, we performed a network meta-analysis to compare the effectiveness of different exercise interventions in improving the visual–spatial working memory of individuals with mild cognitive impairment and Alzheimer’s disease. Subsequently, we explored the moderating variables influencing the effectiveness of the exercise interventions through a subgroup analysis.ResultsWe included 34 articles involving 3,074 participants in the meta-analysis, comprised of 1,537 participants from studies on mild cognitive impairment and 1,537 participants from studies on Alzheimer’s disease. The articles included exhibited an average quality score of 6.6 (score studies) and 6.75 (reaction time [RT] studies), all passing the inconsistency test (p &gt; 0.05). In the mild cognitive impairment literature, mind–body exercise emerged as the most effective exercise intervention (SMD = 0.61, 95% CI: 0.07–1.14). In Alzheimer’s disease research, aerobic exercise was identified as the optimal exercise intervention (SMD = 0.39, 95% CI: 0.06–0.71).ConclusionThe results of the subgroup analysis suggest that the most effective approach to enhancing the visual–spatial working memory of individuals with mild cognitive impairment entails exercising at a frequency of three or more times per week for over 60 min each time and at a moderate intensity for more than 3 months. Suitable exercise options include mind–body exercise, multicomponent exercise, resistance exercise, and aerobic exercise. For individuals with Alzheimer’s disease, we recommend moderately intense exercise twice per week for over 90 min per session and for a duration of 3 months or longer, with exercise options encompassing aerobic exercise and resistance exercise.
Comparison of uncut Roux-en-Y anastomosis and Billroth-II with Braun anastomosis after distal gastrectomy
Authors: Wei Tianxiao , Wu Zhouqiao , Chen Yufan , Li Yingai , Pang Fei , Shan Fei , Li Ziyu , Ji Jiafu 
Published: March 2024

BackgroundThis study aimed to compare the clinical outcomes and patient benefits of uncut Roux-en-Y (URY) anastomosis and Billroth-II with Braun (BB) anastomosis after distal gastrectomy.MethodsWe retrospectively reviewed the data of patients who underwent URY or BB anastomosis after distal gastrectomy between March 2015 and December 2017. Clinical characteristics, survival data, postoperative recovery data, and long-term outcomes were recorded and compared between the two groups.ResultsA total of 231 patients were included, with 167 in the URY group and 64 in the BB group. Kaplan–Meier curves for overall survival showed no differences after propensity score matching (p = 0.488). Long-term postoperative quality of life evaluation also showed no significant differences. Compared to the BB group, patients in the URY group had a significantly shorter time to start a liquid diet after propensity score matching (67.6 h vs. 46.5 h, p = 0.003), and a lower occurrence of bile reflux on follow-up gastroscopy (p &lt; 0.001).ConclusionThe URY anastomosis appears to be a feasible method for digestive tract reconstruction after distal gastrectomy, resulting in less bile reflux and better postoperative recovery. However, there is no significant difference between URY and BB anastomosis in terms of overall survival and long-term quality of life.
Tobramycin Systemic Absorption in Lung Transplant Recipients Treated With Inhaled Tobramycin: A Cohort Study
Authors: Sempere Abiu , Los-Arcos Ibai , Sacanell Judith , Berastegui Cristina , Campany-Herrero David , Vima Jaume , Martín-Gómez María Teresa , Sánchez Leire , Martínez-González Daniel , Bravo Carles , Len Oscar , Gavaldà Joan 
Published: March 2024

Inhaled tobramycin treatment has been associated with nephrotoxicity in some case reports, but limited data are available about serum levels and its possible systemic absorption in lung transplant recipients (LTR). We conducted a single-center, observational and retrospective study of all adult (&gt;18 years old) LTR treated with inhaled tobramycin for at least 3 days between June 2019 and February 2022. Trough serum levels were collected and &gt;2 μg/mL was considered a high drug level. The primary outcome assessed the presence of detectable trough levels, while the secondary outcome focused on the occurrence of acute kidney injury (AKI) in individuals with detectable trough levels. Thirty-four patients, with a median age of 60 years, were enrolled. The primary indications for treatment were donor bronchial aspirate bacterial isolation (18 patients) and tracheobronchitis (15 patients). In total, 28 patients (82%) exhibited detectable serum levels, with 9 (26%) presenting high levels (&gt;2 μg/mL). Furthermore, 9 patients (26%) developed acute kidney injury during the treatment course. Median trough tobramycin levels were significantly elevated in invasively mechanically ventilated patients compared to non-ventilated individuals (2.5 μg/mL vs. 0.48 μg/mL) (p &lt; 0.001). Inhaled tobramycin administration in LTRs, particularly in those requiring invasive mechanical ventilation, may result in substantial systemic absorption.
PERBEDAAN TEKANAN AIR PADA MEMBRAN REVERSE OSMOSIS TERHADAP PENURUNAN JUMLAH BAKTERI ESCHERICHIA COLI PADA AIR BERSIH DI INDUSTRI TEKSTIL
Authors: Maulani Fenni , Yulianto Bambang , Irmawartini  
Published: March 2024

Air sangat berguna untuk kepentingan rumah tangga, industri, maupun tempat umum yang lainnya. Penggunaan air bersih di industri tekstil ini digunakan untuk mencuci peralatan makan dan pengolahan bahan makanan. Hasil pemeriksaan laboratorium pada air bersih yang digunakan mengandung bakteri Escherichia coli sebanyak 41 APM/100 ml, sehingga air bersih tidak memenuhi persyaratan karena melebihi nilai ambang batas, sehingga perlu dilakukan pengolahan air bersih dengan menggunakan teknologi membran Reverse Osmosis (RO). Tujuan penelitian ini yaitu untuk mengetahui perbedaan penurunan jumlah bakteri Escherichia coli dengan berbagai variasi tekanan air setelah diberi perlakuan dengan membran RO. Penelitian ini menggunakan tekanan air sebesar 2 bar, 2,5 bar dan 3 bar. Penelitian ini merupakan penelitian eksperimental dengan disain penelitian yang digunakan adalah Pre test post test without control, teknik pengambilan sampel yang digunakan yaitu grab sampling. Analisa penurunan jumlah bakteri Escherichia coli dilakukan secara deskriptif. Tekanan air yang digunakan mampu menurukan bakteri Escherichia coli hingga 0 APM/100 ml, hal ini dapat terjadi karena pori-pori membran RO lebih kecil dibandingkan ukuran bakteri Escherchia coli. Kesimpulan dalam penelitian ini yaitu terdapat perbedaan dari variasi tekanan yang digunakan pada membran RO terhadap penurunan jumlah bakteri Escherichia coli pada air bersih. Untuk penelitian selanjutnya diharapkan untuk mengganti membran RO setiap melakukan pengujian untuk menghindari kondisi jenuh pada membran RO.
KORELASI KEEFEKTIFAN DISKUSI TUTORIAL DAN KINERJA TUTOR TERHADAP NILAI UJIAN BLOK PADA MAHASISWA PREKLINIK FK UNIVERTAS NUSA CENDANA
Authors: Sari Dewi Fadhilah , Nurina Rr. Listyawati , Handoyo Nicholas Edwin 
Published: March 2024

Kurikulum FK UNDANA, mengacu pada SN-DIKTI Tahun 2015 dan Kerangka Kualifikasi Nasional Indonesia (KKNI). Capaian pembelajaran setiap blok dapat dicapai melalui strategi pembelajaran yang mengacu pada penerapan prinsip Student centered, Problem based, Integrated, Community based, Elective, and Sistematic. Salah satu metode pembelajaran yang menerapkan prinsip problem-based learning (PBL) adalah tutorial, dalam tutorial terdapat seorang tutor yang mengarahkan jalannya suatu diskusi tutorial. Tujuan penelitian ini untuk mengetahui korelasi keefektifan diskusi tutorial dan kinerja tutor terhadap nilai ujian blok pada mahasiswa preklinik FK UNDANA. Metode penelitian adalah analitikal observasional dengan rancangan cross sectional menggunakan kuesioner google form. Jumlah sampel 225 responden dari semester 3, 5, dan 7 yang memenuhi kriteria inklusi. Teknik pengambilan sampel menggunakan total sampling. Analisis data secara univariat dan bivariat menggunakan uji korelasi Spearman pada α=0,05. Hasil penelitian rata-rata keefektifan diskusi tutorial sebesar 3,49, lalu rata- rata kinerja tutor sebesar 4,22, serta rata-rata nilai ujian blok pada 3 blok adalah sebesar 73,39. Ada hubungan bermakna dari keefektifan diskusi tutorial dan nilai ujian blok, tidak ada hubungan bermakna dari kinerja tutor dan nilai ujian blok. Kesimpulan penelitian ini, ada hubungan yang bermakna (p=0,015) antara keefektifan diskusi tutorial dengan nilai ujian blok pada mahasiswa preklinik FK UNDANA. Tidak ada hubungan yang bermakna (p=0,078) antara kinerja tutor dengan nilai ujian blok pada mahasiswa preklinik FK UNDANA.
ANALISIS PENGAMBILAN KEPUTUSAN PASANGAN USIA SUBUR UNTUK TIDAK BERPARTISIPASI DALAM PROGRAM KB
Authors: Nifueki Adiyanto Desastra , Riwu Rut Rosina , Sir Amelya Betsalonia 
Published: March 2024

ABSTRACT
The increasing rate of population growth in the 21st century era has become a separate problem for countries in the world. Indonesia is the fourth most populous country in the world, China, India and the United States. The high rate of population growth that is not accompanied by an increase in the quality of the population, the Indonesian government makes efforts to handle and control population growth by implementing the Family Planning program to improve the welfare of mothers and children and create happy and prosperous small families. The purpose of this study was to determine how the fertile couple's decision not to participate in the family planning program at the Kapan Health Center. This type of research is a qualitative research with an exploratory design. The selection of informants used purposive sampling, collecting ten people, namely PUS mothers who were recorded as not actively using family planning, married, >35 years old and had >3 children. Collecting data by means of in-depth interviews, observation, and documentation. Data were analyzed and presented in the form of narrative text. The results showed that husband/family support influenced the mother's decision not to use family planning, health/family planning officers provided information about family planning through direct counseling and mass media, most of the informants chose not to participate in family planning because of the perceived side effects and the use of natural family planning. The results of the writing can be obtained with the key that EFA's decision not to participate in the family planning program is motivated by the support of the husband/family and the mother feels that it is not suitable for the family planning used and the natural use of family planning. Therefore, it is hoped that the role of the public health center can involve the role of the husband in providing information about the importance of the family planning program for families so as to increase the participation of EFA in the family planning program.
Teresy Ferenc wiersze dla dzieci
Authors: Wądolny-Tatar Katarzyna 
Published: March 2024

Poezja dla dorosłych autorki Wypalonej doliny ufundowana jest na traumatycznych doświadczeniach przeszłości. Teresa Ferenc w dzieciństwie (w 1943 roku) przeżyła pacyfikację rodzinnej wsi na Zamojszczyźnie i śmierć rodziców. W twórczości dla dorosłych poetka powraca do tych wydarzeń, kodując je w wyobrażeniach miejsc i osób. Doświadczenia Ferenc dają się też fenograficznie rozpoznać w utworach jej bliskich: Zbigniewa Jankowskiego i córek obojga. Poezja i proza (np. Mała zagłada) starszej z nich, Anny Janko, jest nawet przedmiotem badań w obszarze studiów nad pamięcią, jej epigenetyką, narracją postpamięciową. Znamienne, że w wierszach dla dzieci Ferenc separuje małego odbiorcę od obrazów wojennego zła i własnej pamięci autobiograficznej. Uprawia poetykę wzrostu i relacji, która jest w istocie hołdem dla życia, jego afirmacją. Wskazuje na naturalny rozwój i wspólnotową („ludzko-nie-ludzką”) więź jako uniwersalne czynniki sprzyjające dobrostanowi dziecka, przekładające się też na jego kontakt z otoczeniem, oparty na uważnej i czułej obserwacji, troskliwości i odpowiedzialności. W książkach poetyckich: Najbliższa ojczyzna (1982, il. Majchrzak) oraz Drzewo dziwo (1987, il. Kurłowicz). Ferenc stosuje fokalizacyjną zmienność opisu, przyglądając się cyklowi przyrody i zachodzącym w niej zjawiskom (jak burza czy hydrodynamika morza), nie tracąc z pola widzenia drobin rzeczywistości (jak pestka, płatek śniegu, liść), do których, przy zastosowaniu ruchomej skali i perspektywy, należy niekiedy także jednostka ludzka. Poezja Ferenc wymusza uwagę dla świata, ujawnia więzi i sploty pomiędzy podmiotami i przedmiotami, uwypukla ich relacyjny charakter. Sprawstwo jest tu podyktowane czynnikami naturalnymi, biotycznością czy wegetacyjnością, ale wynika również z aktu tworzenia i metarefleksji, nierzadko nakładanych na te pierwsze sfery. Większość utworów, które złożyły się na obie książki poetyckie, miała swój pierwodruk w latach 70. i 80. XX wieku na łamach „Świerszczyka” i/lub „Głosu Pomorza”. Wybrane wiersze Ferenc weszły w skład znanych antologii poezji dla dzieci, co świadczy o popularności wierszy sopockiej poetki i uznaniu dla jej twórczości adresowanej do najmłodszych w tamtym czasie.
KEEFEKTIFAN PENGOBATAN DIABETES MELLITUS SECARA OBAT SINTESIS DAN BAHAN ALAM : LITERATURE REVIEW ARTIKEL
Authors: Wahyuningsih Eko Sri , Sukmawati Indriani , Septiani Retna Ayu , Winarti Sri Ayu , Ikhtianingsih Windi 
Published: March 2024

Diabetes adalah sekelompok penyakit metabolik kronis yang berhubungan dengan gangguan metabolisme karbohidrat, lemak dan protein. Literatur riview artikel ini bertujuan untuk membandingkan efektivitas pengobatan diabetes mellitus secara obat sintesis yaitu metformin dengan obat herbal yaitu Daun Benalu Pada Kayu Jawa (Dendrophthoe petandra L.), Daun Pandan Wangi ( Pandanus amaryllifolius, Daun Yakon (Smallanthus sonchifolius), Kayu Manis (Cinnamomum cassia) dan Brotowali (Tinospora crispa (L) Miers. Berdasarkan perbandingan tersebut diperoleh hasil yang signifikan mengingat penderita diabetes mellitus harus mengkonsumsi obat dalam jangka waktu yang lama, sehingga perlu dikombinasikan antara obat sintesis dengan obat herbal. Pemberian ekstrak kayu manis paling efektif dalam menurunkan glukosa darah karena dengan pemberian konsentrasi terendah dapat menurunkan dan menstabilkan kadar glukosa darah.
Application of Clifford Algebra on Group Theory
Authors: Inamdar Farooqhusain , S. N. Hasan 
Published: March 2024

The orthogonal operators defined as similarity transformations on Euclidean space E can also be considered as group actions on the Clifford Algebra. In this paper, we investigate the finite subgroup of Euclidian space E of Geometric Algebra over a finite dimension vector space E. The hierarchy of the finite subgroups of Clifford Algebra C(E) is depicted through the lattice structure and we discussed the group action of these subgroups on the vector space E. Further, we shall address the number of non-trivial finite subgroups, Normal subgroups, and subnormal series of the subgroup of Clifford Algebra C(E) constructed over the vector space E by performing group action over the subgroup of Clifford Algebra C(E).
Assessment of Quality of Life in Patients of Acne Vulgaris Pre and Post Treatment by Using “Cardiff Acne Disability Index (CADI)
Authors: Vijay P. Gupta, Garima  
Published: March 2024

Acne vulgaris is a chronic inflammatory disease of the pilo-sebaceous unit. It is characterized by seborrhea, non-inflammatory and inflammatory lesions, and scarring. Almost all teenagers can expect some degree of acne, with moderate to severe disease in about 15% of 15-17-year-olds. Acne develops earlier in girls, but more boys are affected.
Background and Aims
This study is designed to To study, the quality of life in patients of acne vulagris, pre and post treatment using “CARDIFF ACNE DISABILITY INDEX (CADI)”
Method
In this study 60 patients having acne vulgaris attending the Out Patient department of Dermatology were included as subjects for the study. The Cardiff Acne Disability Index (CADI) (Motley and Finlay, 1992) CADI4, a five-item questionnaire is used to asses the impact of acne on quality of life of acne patients.
Results
The Quality of life on the whole was found to be significantly affected in pre-treatment acne patients as compared to post-treatment acne patients (p< 0.001). The CADI score correlated with the severity of acne (p<0.001). In summary, the findings of the present study indicate that CADI is a reliable and valid measure of acne impact on quality of life in patients with this condition.
Conclusion
The impact of acne on quality of life can be measured using general health measures, dermatology-specific measures or acne-specific measures. Quality of life measures can influence the choice of therapy. In patients with a severe impact on their quality of life, a more aggressive therapy may be justified.