bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring subungual onycholemmal cysts: A rare case report and comprehensive literature review
Authors: Giv Toktam Safari , Movahedi Mahdiyeh , Dadkhahfar Sahar , Biglari Farsad , Rakhshan Azadeh , Mardani Ghazal , Kafiabadi Meisam Jafari 
Published: April 2024

Key clinical messageSubungual Onycholemmal Cyst (SOC) is a rare nail abnormality with different clinical presentations which can mimic different nail malignancies, such as melanoma, SCC, or glomus tumor. It is necessary for dermatologists and dermatopathologist to be aware of this pathology to make the proper diagnosis and treatment. SOC is a rare nail abnormality which affects the dermis of the nail bed. SOC has different clinical presentations, including onychodystrophy, ridging, clubbing, thickening, pigmentation, or even normal appearance. It can mimic different nail malignancies, such as melanoma, SCC, or glomus tumor. In this report, we describe a 54‐year‐old man with unilateral second right finger nail onychodystrophy and onycholysis for 1 year. He did not have any history of recent trauma, pain, or bleeding. It was completely resected by surgery. Nail biopsy can contribute to the early diagnosis of SOC and improvement of treatment outcomes.
First‐trimester exposure to tofacitinib in ulcerative colitis: A case report of a healthy newborn and literature review
Authors: Arzivian Arteen , Zhang Eva , Laube Robyn , Leong Rupert 
Published: April 2024

Key Clinical MessageTofacitinib is contraindicated in pregnancy. We present a patient with ulcerative colitis on tofacitinib who had an unplanned pregnancy. Tofacitinib was ceased, switched to vedolizumab, and she gave birth to a healthy newborn at term. Case reports of reassuring outcomes provide real‐world data that assists decision‐making for future patients.
LncRNA ZFAS1 promotes invasion of medullary thyroid carcinoma by enhancing EPAS1 expression via miR‐214‐3p/UCHL1 axis
Authors: Chen Wenjing , Wang Shaoqing , Wei Dongmei , Zhai Lili , Liu Li , Pan Chunlei , Han Zhongshu , Liu Huiming , Zhong Wei , Jiang Xin 
Published: April 2024

AbstractlncRNA ZFAS1 was identified to facilitate thyroid cancer, but its role in medullary thyroid carcinoma (MTC) remains unknown. This study aimed to unravel the potential function of this lncRNA in MTC by investigating the involvement of the lncRNA ZFAS1 in a ceRNA network that regulates MTC invasion. Proliferation, invasion, and migration of cells were evaluated using EdU staining and Transwell assays. Immunoprecipitation (IP) assays, dual‐fluorescence reporter, and RNA IP assays were employed to examine the binding interaction among genes. Nude mice were used to explore the role of lncRNA ZFAS1 in MTC in vivo. ZFAS1 and EPAS1 were upregulated in MTC. Silencing ZFAS1 inhibited MTC cell proliferation and invasion under hypoxic conditions, which reduced EPAS1 protein levels. UCHL1 knockdown increased EPAS1 ubiquitination. ZFAS1 positively regulated UCHL1 expression by binding to miR‐214‐3p. Finally, silencing ZFAS1 significantly repressed tumor formation and metastasis in MTC. LncRNA ZFAS1 promotes invasion of MTC by upregulating EPAS1 expression via the miR‐214‐3p/UCHL1 axis.
Scutellarin alleviates microglia‐mediated neuroinflammation and apoptosis after ischemic stroke through the PI3K/AKT/GSK3β signaling pathway
Authors: Duan Zhaoda , Chen Haolun , Miao Wei , He Jing , Xu Dongyao , Qi Zhi , Yang Li , Jia Wenji , Wu Chunyun 
Published: April 2024

AbstractMicroglia are resident immune cells in the central nervous system that are rapidly activated to mediate neuroinflammation and apoptosis, thereby aggravating brain tissue damage after ischemic stroke (IS). Although scutellarin has a specific therapeutic effect on IS, the potential target mechanism of its treatment has not been fully elucidated. In this study, we explored the potential mechanism of scutellarin in treating IS using network pharmacology. Lipopolysaccharide (LPS) was used to induce an in vitro BV‐2 microglial cell model, while middle cerebral artery occlusion (MCAO) was used to induce an in vivo animal model. Our findings indicated that scutellarin promoted the recovery of cerebral blood flow in MCAO rats at 3 days, significantly different from that in the MCAO group. Western blotting and immunofluorescence revealed that scutellarin treatment of BV‐2 microglial cells resulted in a significant reduction in the protein expression levels and incidence of cells immunopositive for p‐NF‐κB, TNF‐α, IL‐1β, Bax, and C‐caspase‐3. In contrast, the expression levels of p‐PI3K, p‐AKT, p‐GSK3β, and Bcl‐2 were further increased, significantly different from those in the LPS group. The PI3K inhibitor LY294002 had similar effects to scutellarin by inhibiting neuroinflammation and apoptosis in activated microglia. The results of the PI3K/AKT/GSK3β signaling pathway and NF‐κB pathway in vivo in MCAO models induced microglia at 3 days were consistent with those obtained from in vitro cells. These findings indicate that scutellarin plays a neuroprotective role by reducing microglial neuroinflammation and apoptosis mediated by the activated PI3K/AKT/GSK3β/NF‐κB signaling pathway.
Defect Induced Structural Transition and Lipase Immobilization in Mesoporous Aluminum Metal‐Organic Frameworks
Authors: Kulandaivel Sivasankar , Yang Chun‐Chuen , Yeh Yi‐Chun , Lin Chia‐Her 
Published: April 2024

AbstractThe transition from disorder to order and structural transformation are distinctive metal‐organic framework (MOF) features. How to adapt or control both behaviors in MOF has rarely been studied. In this case, we demonstrate that our successful synthesis of [Al(OH)(PDA)]n (AlPDA‐53‐DEF, AlPDA‐53‐H, and AlPDA‐68) with H2PDA=4,4′‐[1,4‐phenylenebis(ethyne‐2,1‐diyl)]‐di benzoic acid has shown the intricate world of Aluminum Metal‐Organic Frameworks (Al‐MOFs). It offers profound insights into defect structures to order and transformations. AlPDA‐53‐DEF, in particular, revealed a fascinating interplay of various pore sizes within both micro and mesoporous regions, unveiling a unique lattice rearrangement phenomenon upon solvent desorption. Defects and disorders emerged as crucial impacts of transforming AlPDA‐53‐DEF, with its initially imperfect crystallinity, into the highly crystalline, hierarchically porous AlPDA‐53‐H.
Total Chemical Synthesis of Aggregation‐Prone Disulfide‐Rich Starfish Peptides
Authors: Wu Hongkang , Praveen Praveen , Handley Thomas N. G. , Chandrashekar Chaitra , Cummins Scott F. , Bathgate Ross A. D. , Hossain Mohammed Akhter 
Published: April 2024

AbstractA relaxin‐like gonad‐stimulating peptide (RGP), Aso‐RGP, featuring six cysteine residues, was identified in the Crown‐of‐Thorns Starfish (COTS, Acanthaster cf. solaris) and initially produced through recombinant yeast expression. This method yielded a single‐chain peptide with an uncleaved C‐peptide (His Tag) and suboptimal purity. Our objective was to chemically synthesize Aso‐RGP in its mature form, comprising two chains (A and B) and three disulfide bridges, omitting the C‐peptide. Furthermore, we aimed to synthesize a newly identified relaxin‐like peptide, Aso‐RLP2, from COTS, which had not been previously synthesized. This paper reports the first total chemical synthesis of Aso‐RGP and Aso‐RLP2. Aso‐RGP synthesis proceeded without major issues, whereas the A‐chain of Aso‐RLP2, in its reduced and unfolded state with two free thiols, presented considerable challenges. These were initially marked by “messy” RP‐HPLC profiles, typically indicative of synthesis failure. Surprisingly, oxidizing the A‐chain significantly improved the RP‐HPLC profile, revealing the main issue was not synthesis failure but the peptide's aggregation tendency, which initially obscured analysis. This discovery highlights the critical need to account for aggregation in peptide synthesis and analysis. Ultimately, our efforts led to the successful synthesis of both peptides with purities exceeding 95 %.
Consumption of cow's milk formula in the nursery and the development of milk allergy
Authors: Elizur Arnon , Rachel‐Jossefi Shirel , Rachmiel Marianna , Eisenberg Eli , Katz Yitzhak 
Published: April 2024

AbstractBackgroundThe effect of the amount of transient cow's milk formula (CMF) consumed during the first days of life on IgE‐cow's milk allergy (IgE‐CMA) is unknown.MethodsA cohort of 58 patients with IgE‐CMA was identified from a large scale population‐based study of 13,019 infants followed from birth. A group of 116 infants matched for sex and breastfeeding only duration (beyond the nursery period), and another random group of 259 healthy infants were used as controls. Parents were interviewed and the infants' medical records were searched to assess CMF consumption in the nursery.ResultsWhile 96% of the mothers of the 174 infants (58 with Cow's milk allergy and 116 controls) reported on exclusive breastfeeding during the stay in the nursery, CMF consumption was documented in 96 (55%) of the infants. Of those, most (57; 59%) received one to three feedings, 20 (21%) received four to nine feedings, and 19 (20%) received ≥10 feedings. Fewer formula feeds (1–3) were significantly more common in the allergic group than ≥4 feeds (p = 0.0003) and no feeds at all (p = 0.02) compared to controls (n = 116). Of those exclusively breastfed in the nursery, 13/23 allergic infants (57%) introduced CMF at age 105–194 days (the period with highest‐risk for IgE‐CMA) compared to 33/98 (34%) from the random control group (n = 259) (p = 0.04).ConclusionsMost infants end up receiving few CMF feeds in the nursery. Transient CMF in the nursery is associated with increased risk of IgE‐CMA.
Atypical squamous cells in urine cytology are associated with a significant risk of high‐grade malignancy
Authors: Ho Linh , Elsheikh Tarik M. 
Published: April 2024

AbstractBackgroundAtypical squamous cells (ASC) in urine cytology are rarely found, and their clinical significance is not well studied. Previous studies were limited by a small number of cases and a lack of objective grading of ASC and/or their correlation with accompanying urothelial cell abnormality (UCA).MethodsThe institutional database was searched over 10 years for urine cytology reports containing ASC or from patients who had a concurrent diagnoses of high‐grade (HG) urothelial carcinoma with squamous differentiation or squamous carcinoma. ASC were defined as keratinized squamous cells and were subcategorized as reactive, koilocytosis, low‐grade (LG) atypia, and HG atypia. Correlations with age, sex, specimen type, accompanying UCA, number of ASC, and the risk of HG malignancy (ROHM) were assessed.ResultsASC were present in 0.15% of all urine specimens (123 of 81,018). Slides and clinical follow‐up were available on 91 patients (median age, 71 years). LG and HG squamous atypia had ROHMs of 70% and 92%, respectively. ASC not accompanied and accompanied by UCA had ROHMs of 37% and 94%, respectively. Most malignancies (34 of 67; 51%) showed rare ASC in urine. Reactive changes and koilocytosis had 0% ROHM.ConclusionsASC in urine cytology is a significant finding and is associated with a high ROHM. In the absence of accompanying UCA, LG squamous atypia had a lower ROHM than HG atypia. In the presence of UCA, LG and HG squamous atypia had ROHMs of over 90%. These findings suggest that ASC and their grade of atypia should be noted in the cytology report, and clinicians should be made aware of their clinical significance.
Diagnostic accuracy of International System for Reporting Serous Fluid Cytopathology: A systematic review and meta‐analysis in malignancy diagnosis
Authors: Ahuja Sana , Ahuja Rhea , Pandey Shivam , Zaheer Sufian 
Published: April 2024

AbstractThis study conducts the first meta‐analysis to assess the aggregated risk of malignancy associated with each category of the International System for Reporting Serous Fluid Cytopathology (ISRSFC) for reporting serous effusion cytology, while also evaluating diagnostic accuracy. PubMed/MEDLINE and Embase were systematically searched using the keywords “(pleural, peritoneal, and pericardial effusions) AND (serous effusion cytology) OR (International System for Reporting Serous Fluid Cytopathology)”. Articles underwent risk of bias assessment using the QUADAS‐2 tool. After excluding inadequate samples, a meta‐analysis determined sensitivity and specificity for different cutoff points, including "atypical considered positive," "suspicious of malignancy considered positive," and "malignant considered positive." Summary receiver operating characteristic curves assessed diagnostic accuracy, and the diagnostic odds ratio was pooled. Sixteen retrospective cross‐sectional studies, totaling 19,128 cases, were included. Sensitivity and specificity for the “atypical and higher risk categories” considered positive were 77% (95% confidence interval [CI], 68%–84%) and 95% (95% CI, 93%–97%) respectively. For the “suspicious for malignancy and higher risk categories” considered positive, sensitivity and specificity were 57% (95% CI, 49%–65%) and 100% (95% CI, 99%–100%) respectively. Sensitivity and specificity for the “malignant” category considered positive for malignancy were 70% (95% CI, 60%–77%) and 99% (95% CI, 98%–99%), respectively. The pooled area under the curve ranged from 85% to 89.5% for each cutoff. This meta‐analysis underscores the ISRSFC's accuracy in reporting serous fluid cytology. It emphasizes the diagnostic importance of the "suspicious" and "malignant" categories in identifying malignancy, and the role of the "benign" category in ruling out malignancy.
Analyzing color training in design education: A review from 2010 to 2022
Authors: Calvo Ivanovic Ingrid 
Published: April 2024

AbstractThis study was part of a doctoral research project which looked into the current issues with color education, documented by several authors in recent years. It presents a comprehensive analysis of 103 color courses taught within design programs of higher education institutions from different countries over the last 12 years, 2010–2022. The analysis aimed to define the state‐of‐the‐art of including color training within higher education design programs, identify the main didactic strategies implemented, and recognize the main critical aspects to face when proposing an innovative framework for color training. Among the formal aspects analyzed are the course level, the course duration, the student entry profile, the specific disciplinary area, the course location, the type of institution, and the language of the course. The didactic strategy elements analyzed were the learning outcomes, the contents proposed by the course, the teaching strategies implemented, and the suggested bibliography. Finally, a description of the main findings of the analysis is provided to assess how color is being taught within the design area.
A superpixel‐based color difference detection algorithm for dyed fabrics
Authors: Yuan QiLei , He ZhiYong , Wan SiJie 
Published: April 2024

AbstractIn order to enhance the accuracy and efficiency of color difference detection for dyed fabrics, this article introduces a novel superpixel‐based color difference detection algorithm, which exhibits three significant improvements over the previous algorithm. First, it proposes a more rational color feature extraction method to extract more detailed color features from fabric images, which uses superpixels as basic units for both color feature extraction and color difference detection. Second, the algorithm employs the CIEDE2000 color difference formula to calculate color difference values. This eliminates the need for obtaining standard fabric images as references in advance, making the process more convenient and practical. Finally, an area‐based color difference calculation method is proposed based on the human visual mechanism, ensuring that the evaluation results are more consistent with human eye observations. Experimental results demonstrate that the proposed algorithm provides more accurate and visually consistent color difference assessments compared to the previous algorithm.
Combining Desferriferrioxamine B and 1‐Hydroxy‐2‐Piperidone ((PIPO)H) to Chelate Zirconium. Solution Structure of a Model Complex of the [89Zr]Zr−DFOcyclo*−mAb Radioimmunoconjugate
Authors: Mangin Floriane , Fonquernie Osian , Jewula Pawel , Brandès Stéphane , Penouilh Marie‐José , Bonnin Quentin , Vincent Bruno , Espinosa Enrique , Aubert Emmanuel , Meyer Michel , Chambron Jean‐Claude 
Published: April 2024

Abstract89Zr−immunoPET is a hot topic as 89Zr cumulates the advantages of 64Cu and 124I without their drawbacks. We report the synthesis of a model ligand of a chiral bioconjugable tetrahydroxamic chelator combining the desferriferrioxamine B siderophore and 1‐hydroxy‐2‐piperidone ((PIPO)H), a chiral cyclic hydroxamic acid derivative, and the study by NMR spectroscopy of its zirconium complex. Nuclear Overhauser effect measurements (ROESY) indicated that the complex exists in the form of two diastereomers, in 77 : 23 ratio, resulting from the combination of the central chiralities at the 3‐C of the (PIPO)H component and at the Zr4+ cation. The 44 lowest energy structures out of more than 1000 configurations/conformations returned by calculations based on density functional theory were examined. Comparison of the ROESY data and the calculated interatomic H⋅⋅⋅H distances allowed us to select the most probable configuration and conformations of the major complex.
Enhancing the Performance of 2D Ni‐Fe Layered Double Hydroxides by Cabbage‐Inspired Carbon Conjunction for Oxygen Evolution Reactions
Authors: Chen Youming , Gu Xinrui , Guo Song , Zhang Jingjing , Barkaoui Sami , Xu Liangliang , Li Gao 
Published: April 2024

AbstractLayered double hydroxide (LDH) nanosheets as one type of two‐dimensional materials have garnered increasing attention in the field of oxygen evolution reaction (OER) in recent decades. To address the challenges associated with poor conductivity and limited electron and charge transfer capability in LDH materials, we have developed a straightforward one‐pot synthesis method to successfully fabricate a composite material with a microstructure resembling cabbage, which encompasses NiFe‐LDH and nanocarbon (referred as NiFe‐LDH@C). Atomic force microscopy (AFM) and high‐resolution transmission electron microscopy (HRTEM) revealed that the monolayer NiFe‐LDH with a height of ~0.5–0.8 nm is uniformly distributed and closely bonded to the carbon support, leading to a significant enhancement in conductivity and facilitating faster electron and charge transfer. Moreover, the NiFe‐LDH@C exhibits a substantial number of surface defect sites, which enhances the interaction with oxygen species. This dual enhancement in charge transfer and oxygen species‐mediated transfer greatly improves the catalytic OER performance, which is further corroborated by theoretical calculations. Notably, the Ni10Fe6‐LDH@C with the highest concentration of surface oxygen vacancies demonstrated superior water oxidation performance, surpassing commercially available RuO2 catalysts; an OER overpotential of 231 mV@10 mA cm−2 with a Tafel slope of 71 mV dec−1 was achieved.
General and Facile Synthesis of Co/CoO Nanoparticals Supported by Nitrogen‐Doped Graphenic Networks as Efficient Oxygen Electrocatalyst for Zn‐Air Batteries
Authors: Tian Xin , Xu Mengnan , Ma Xin , Mu Guanyu , Xiao Junwu , Wang Shuai 
Published: April 2024

AbstractReasonable design of low‐cost, high‐efficiency and stable bifunctional oxygen electrocatalysts is of great significance to improve the reaction efficiency of Zn‐air batteries, which is still a huge challenge. Here, we report a highly efficient bifunctional oxygen electrocatalyst with three‐dimensional (3D) N‐doped graphene network‐supported cobalt and cobalt oxide nanoparticles (Co/CoO‐NG), which can be in situ synthesized by inducing metal ions on metal plates via graphene oxide as an inducer. This 3D network structure and open active center show excellent bifunctional oxygen electrocatalytic activity under alkaline conditions, and can be used as an air electrode in rechargeable Zn‐air batteries, with significantly better power density (244.28 mW cm−2) and stability (over 340 h) than commercial Pt/C+RuO2 mixtures. This work is conducive to advancing the practical application of graphene‐based materials as air electrodes for rechargeable zinc‐air batteries.
Improving species distribution forecasts by measuring and communicating uncertainty: An invasive species case study
Authors: Thomas Shyam M. , Verhoeven Michael R. , Walsh Jake R. , Larkin Daniel J. , Hansen Gretchen J. A. 
Published: April 2024

AbstractForecasting invasion risk under future climate conditions is critical for the effective management of invasive species, and species distribution models (SDMs) are key tools for doing so. However, SDM‐based forecasts are uncertain, especially when correlative statistical models extrapolate to nonanalog environmental domains, such as future climate conditions. Different assumptions about the functional form of the temperature–suitability relationship can impact predicted habitat suitability under novel conditions. Hence, methods to understand the sources of uncertainty are critical when applying SDMs. Here, we use high‐resolution predictions of lake water temperatures to project changes in habitat suitability under future climate conditions for an invasive macrophyte (Myriophyllym spicatum). Future suitability was predicted using five global circulation models and three statistical models that assumed different species–temperature functional responses. The suitability of lakes for M. spicatum was overall predicted to increase under future climate conditions, but the magnitude and direction of change in suitability varied greatly among lakes. Variability was most pronounced for lakes under nonanalog temperature conditions, indicating that predictions for these lakes remained highly uncertain. Integrating predictions from SDMs that differ in their species–environment response function, while explicitly quantifying uncertainty across analog and nonanalog domains, can provide a more robust and useful approach to forecasting invasive species distribution under climate change.
Transthyretin amyloid cardiomyopathy among patients with heart failure and preserved ejection fraction: the AMY score
Authors: Gioia Guglielmo , Schrutka Lore , Jozwiak‐Nozdrzykowska Joanna , Kresoja Karl‐Patrik , Gunold Hilka , Klingel Karin , Thiele Holger , Bonderman Diana , Lurz Philipp , Rommel Karl‐Philipp 
Published: April 2024

AbstractAimsTransthyretin ‘wild‐type’ amyloid cardiomyopathy (ATTRwt‐CM) is a differential diagnosis of heart failure with preserved ejection fraction (HFpEF). The clinical work‐up for ATTRwt‐CM is challenging. Considering a combination of clinical variables specific for ATTRwt‐CM might aid in identifying patients at risk.Methods and resultsSixty patients (78 ± 6 years, 8% female) were diagnosed with ATTRwt‐CM by endomyocardial biopsy. Preserved ejection fraction (LVEF >45%) was present in 41 of the patients. Those were 1:1 propensity score age‐ and sex‐matched to a cohort of patients with HFpEF. ATTRwt‐CM patients had less obesity (P = 0.01) and higher septal thickness (IVSd, P < 0.01) as well as more diastolic dysfunction (E/e′, P < 0.01). On multivariable regression IVSd > 14 mm, E/e′ > 14 and absence of obesity (P > 0.01 for all) were identified as predictors for ATTRwt‐CM. A weighted point‐based score was derived with IVSd > 14 mm = 1 point; absence of obesity = 2 points; and E/e′ > 14 = 3 points. Area under the curve (AUC) for the summation score was 0.91 (0.84–0.97, P < 0.01) and a score of more than 3 points predicted ATTRwt‐CM with good sensitivity (78%) and specificity (90%). The score was validated in an external cohort of 142 patients with ATTRwt‐CM and 419 HFpEF patients showing sufficient accuracy (AUC 0.91, 0.88–0.94, P < 0.01). A value greater than 3 points demonstrated a high sensitivity (93%) and a negative predictive value of 97%.ConclusionsA score based on basic clinical and echocardiographic features helps to distinguish ATTRwt‐CM from typical HFpEF. This could facilitate the diagnostic work‐up for these patients and enable earlier disease screening on a large scale.