bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fault detection of wind turbine system based on data-driven methods: a comparative study
Authors: Elshenawy Lamiaa M. , Gafar Ahmed A. , Awad Hamdi A. , AbouOmar Mahmoud S. 
Published: March 2024

AbstractFault detection plays a crucial role in ensuring the safety, availability, and reliability of modern industrial processes. This study focuses on data-driven fault detection methods, which have gained significant attention across various industrial sectors due to the rapid development of industrial automation technologies and the availability of extensive datasets. The objectives of this paper are to comprehensively review and present the theoretical foundations of widely used data-driven fault detection approaches. Specifically, these approaches are applied to fault detection in wind turbine systems, with performance evaluation conducted using multiple statistical measures. The data utilized in this study were collected from a simulated benchmark of a wind turbine system. The data-driven methods are tested under the assumption that the wind turbine operates in a steady-state region. Additionally, a comparative study is conducted to identify and discuss the primary challenges associated with the practical application of these methods in real-world scenarios. Simulation results show the effectiveness and efficacy of data-driven approaches concerning the sensitivity and robustness of wind turbine sensor faults as applied in practical industrial environments.
Exposure of Cryptococcus neoformans to low nitrogen levels enhances virulence
Authors: Bosch Caylin , Toplis Barbra , Van Staden Anton DuPreez , Volschenk Heinrich , Smith Carine , Dicks Leon , Botha Alfred 
Published: March 2024

AbstractPrevious studies have shown a correlation between nitrogen levels and Cryptococcus neoformans pathogenicity. Here we report on the in vivo effects of cryptococcal pre-exposure to ecologically relevant nitrogen levels. C. neoformans H99 was cultured in yeast carbon base (YCB) supplemented with 0.53 g/L NH4Cl and 0.21 g/L NH4Cl, respectively, and used to infect larvae of the Greater Wax moth, Galleria mellonella. Cells cultured in low nitrogen YCB (LN) were more virulent compared to cells cultured in high nitrogen YCB (HN). Microscopic examination of haemolymph collected from infected larvae revealed that cells cultured in LN were larger than cells cultured in HN, with the majority of LN cells exceeding 10 µm and possibly entering titanisation. Additionally, compared to HN-cultured cells, fewer LN-cultured cells were engulfed by macrophages. The enhanced virulence of LN-cultured cells was attributed to the increased cell size in vivo. In contrast, reduced macrophage uptake was attributed to increased capsule thickness of in vitro cells. Not only do these findings demonstrate the effects of culture conditions, specifically nitrogen levels, on C. neoformans virulence, but they also highlight the importance of isolate background in the cryptococcal-host interaction.
Antivirals to prepare for surges in influenza cases: an economic evaluation of baloxavir marboxil for the Netherlands
Authors: van der Pol Simon , Postma Maarten J. , Boersma Cornelis 
Published: March 2024

Abstract
Objectives
We perform a cost-effectiveness analysis (CEA) and budget impact analysis (BIA) of baloxavir marboxil compared to current care in the Netherlands for patients at risk of influenza-related complications, including patients with comorbidities and the elderly.

Methods
In the CEA, a decision tree model was developed to assess the cost-effectiveness of baloxavir marboxil for a cohort of 52-year-olds from a societal perspective. A lifetime horizon was taken by incorporating the quality-adjusted life expectancy. The BIA included different epidemiological scenarios, estimating different plausible epidemiological scenarios for seasonal influenza considering the whole Dutch population with an increased risk of influenza complications.

Results
The base-case ICER was estimated to be €8,300 per QALY. At the willingness-to-pay threshold of €20,000 per QALY, the probability of being cost effective was 58%. The base-case expected budget impact was €5.7 million on average per year, ranging from €1.5 million to €10.5 million based on the severity of the influenza epidemic and vaccine effectiveness.

Conclusion
In the Netherlands, baloxavir is a cost-effective treatment option for seasonal influenza, with a base-case ICER of €8,300 per QALY for the population aged 60 years and over and patients at high risk of influenza-related complications. For a large part, this ICER is driven by the reduction of the illness duration of influenza and productivity gains in the working population.
User journey games: automating user-centric analysis
Authors: Kobialka Paul , Lizeth Tapia Tarifa S. , Bergersen Gunnar R. , Johnsen Einar Broch 
Published: March 2024

AbstractThe servitization of business is moving industry to business models driven by customer demand. Customer satisfaction is connected with financial rewards, forcing companies to invest in their users’ experience. User journeys describe how users maneuver through a service. Today, user journeys are typically modeled graphically, and lack formalization and analysis support. This paper proposes a formalization of user journeys as weighted games between the user and the service provider and a systematic data-driven method to derive these user journey games from system logs, using process mining techniques. As the derived games may contain cycles, we define an algorithm to transform user journeys games with cycles into acyclic weighted games, which can be model checked using "Image missing" to uncover potential challenges in a company’s interactions with its users and derive company strategies to guide users through their journeys. Finally, we propose a user journey sliding-window analysis to detect changes in the user journey over time by model checking a sequence of generated games. Our analysis pipeline has been evaluated on an industrial case study; it revealed design challenges within the studied service and could be used to derive actionable recommendations for improvement.
Assessment of overlapping triple-frequency BDS-3/BDS-2/INS tightly coupled integration model in kinematic surveying
Authors: Xiao Kai , Sun Fuping , Zhu Xiangwei , Zhou Peiyuan , Ma Yuexin , Wang Yue 
Published: March 2024

AbstractThe China BeiDou Navigation Satellite System (BDS-3) is recognized for its advantages compared to BDS-2. However, the enhancement of performance through the simultaneous utilization of BDS-2 and BDS-3 in real-time kinematic (RTK) applications remains insufficiently investigated. Herein, we developed an overlapping triple-frequency (TF) BDS-3/BDS-2/inertial navigation system (INS) tightly coupled (TC) integration model that takes advantage of the BDS-3/BDS-2 overlapping frequencies of B1I/B2b(B2I)/B3I for intersystem combination and INS-assisted positioning. An analytical formula for ambiguity dilution of precision (ADOP) was derived, serving as the foundation for an exploration into how multi-frequency measurements and INS assistance affect ambiguity resolution (AR). A vehicle experiment was conducted in a city to evaluate the performance of the measurement models for various frequencies, available satellites, and INS assistance. Analysis of the double differencing errors of the pseudorange and carrier phases revealed that a robust model in kinematic situations is preferred over static situations. AR ability was assessed regarding ADOP, ratio test, and success rates, and the positioning and attitude determination results were examined. Overall, the characteristics of the ADOP analytic formula and processing results produce a similar conclusion regarding the contribution of multi-frequency, available measurements, and INS assistance on AR; further, they provide reference values for moving measuring system users to implement the optimal model in kinematic situations.
Understanding pre-service mathematics teachers’ intentions to use GeoGebra: The role of technological pedagogical content knowledge
Authors: Yildiz Esra , Arpaci Ibrahim 
Published: March 2024

AbstractThe research investigated the “Technological Pedagogical Content Knowledge” (TPACK) of pre-service mathematics teachers and its impact on their sustained intention to utilize GeoGebra in teaching mathematics. This study introduced a novel research model by extending the “Unified Theory of Acceptance and Use of Technology” (UTAUT) with TPACK. Through “Structural Equation Modeling” (SEM) applied to data collected from 205 pre-service teachers, the research model was evaluated. The results revealed that factors like effort expectancy, social influence, performance expectancy, and TPACK significantly predicted the continuous use intention of GeoGebra. However, no substantial relationship was found concerning facilitating conditions. The findings have managerial and practical implications for academics, teachers, principals, and decision-makers promoting the use of GeoGebra in educational settings.
S77C-ΔC7-CueR: a 199mHg PAC study of the protein metal site structure
Authors: Balogh R. K. , Jancso A. , Gyurcsik B. , Schell J. , Correia J. G. , Thulstrup P. W. , Hemmingsen L. 
Published: March 2024

AbstractThe CueR protein regulates the cytosolic concentration of Cu(I) in bacteria such as E. coli. With this work we aimed to remodel the linear two-coordinate metal site with Cys112 and Cys120 as ligands in CueR to a tricoordinate site similar to that observed in the Hg(II) sensor protein MerR. This was done by introducing an additional cysteine near the metal site in the modified S77C-ΔC7-CueR variant, inspired by the fact that Ser77 in CueR is replaced by a cysteine in MerR. 199mHg PAC spectroscopic data indicate that two NQIs are present at pH 8.0, most likely reflecting HgS2 and HgS3 coordination modes, and demonstrating that the design of a pure HgS3 metal site was not achieved. Lowering the pH to 6.0 or the temperature to −196 °C had surprisingly similar effects, giving rise to highly distorted trigonal Hg(II) coordination. Tentatively, this might reflect that the histidine just next to Cys77 (His76) coordinates forming a HgS2N metal site structure. Further redesign beyond the first coordination sphere appears to be required to efficiently stabilize the HgS3 metal site structure at physiological pH.
Ocular injuries associated with motor vehicle accidents: long term effects on quality of life
Authors: Brody Judith , Ben Ishai Meydan , Serov-Volach Irena , Mano-Tamir Keren , Gaton Dan D. , Avisar Inbal 
Published: March 2024

Abstract
Purpose
To describe the prevalence and outcome of motor vehicle accidents-associated ocular injuries.

Methods
A survey of patients who presented to the emergency room at a level 1 trauma center with motor vehicle accidents-associated ocular injuries. A patient questionnaire and review of clinical notes were conducted for all patients.

Results
Of 274 motor vehicle accident victims with ocular injuries who presented to the emergency room, 40 (15%) responded to the survey. Over half of them were driving a vehicle, and most reported wearing a seat belt or a helmet. Most ocular injuries were mild. The most common injuries were bone fractures, subconjunctival hemorrhage, eyelid involvement and corneal injury. Most respondents had no change in vision and perceived their ocular involvement as a minor part of their injury. Most respondents returned to work and to driving within a year.

Conclusion
Our study sheds light on the details and extent of ocular involvement and the visual ability to perform daily activities following motor vehicle accidents.
Pituitary tumours without distinct lineage differentiation express stem cell marker SOX2
Authors: Lenders Nèle F. , Thompson Tanya J. , Chui Jeanie , Low Julia , Inder Warrick J. , Earls Peter E. , McCormack Ann I. 
Published: March 2024

Abstract
Context
The recent WHO 2022 Classification of pituitary tumours identified a novel group of ‘plurihormonal tumours without distinct lineage differentiation (WDLD)’. By definition, these express multiple combinations of lineage commitment transcription factors, in a monomorphous population of cells.

Objectives
To determine the expression of stem cell markers (SOX2, Nestin, CD133) within tumours WDLD, immature PIT-1 lineage and acidophil stem cell tumours, compared with committed cell lineage tumours.

Methods
Retrospective evaluation of surgically resected pituitary tumours from St Vincent’s Hospital, Sydney. Patients were selected to cover a range of tumour types, based on transcription factor and hormone immunohistochemistry. Clinical data was collected from patient files. Radiology reports were reviewed for size and invasion. Samples were analysed by immunohistochemistry and RT-qPCR for SF-1, PIT-1, T-PIT, SOX2, Nestin and CD133. Stem cell markers were compared between tumours WDLD and those with classically “mature” types.

Results
On immunohistochemistry, SOX2 was positive in a higher proportion of tumours WDLD compared with those meeting WHO lineage criteria, 7/10 v 10/42 (70 v 23.4%, p = 0.005). CD133 was positive in 2/10 tumours WDLD but 0/41 meeting lineage criteria, P = 0.003. On RT-qPCR, there was no significant difference in relative expression of stem cell markers (SOX2, CD133, Nestin) between tumours with and WDLD.

Conclusions
Our study is the first to biologically characterise pituitary tumours WDLD. We demonstrate that these tumours exhibit a higher expression of the stem cell marker SOX2 compared with other lineage-differentiated tumours, suggesting possible involvement of stem cells in their development.
Balancing democracy: majoritarianism versus expression of preference intensity
Authors: Nitzan Asaf D. M. , Nitzan Shmuel I. 
Published: March 2024

AbstractThis paper evaluates three prominent voting systems: the Majority Rule (MR), Borda Rule (BR), and Plurality Rule (PR). Our analysis centers on the susceptibilities of each system to potential transgressions of two foundational principles: the respect for majority preference (majoritarianism) and the acknowledgment of the intensity of individual preferences. We operationalize the concept of 'cost' as the expected deviation from the aforementioned principles. A comparative assessment of MR, BR, and PR is undertaken in terms of their costs. Our findings underscore the superiority of PR over MR, whilst also highlighting the comparative advantage of MR against BR.
Are family firms green?
Authors: Miroshnychenko Ivan , Miller Danny , De Massis Alfredo , Le Breton-Miller Isabelle 
Published: March 2024

Abstract
This study examines environmental management practices of 1690 family and nonfamily firms from 29 countries and 19 industrial sectors over an 8-year period. We show that the family effect on firm environmental management practices ranges substantially, from extremely negative to no effect at all. Moreover, the magnitude of the effect depends on the type of firm, the industrial context, the type of economy, and the stages of the business cycle. This study offers a novel understanding of the extreme heterogeneity of environmental management practices of family businesses and serves as a springboard for future research aiming to better understand the environmental strategies of publicly traded firms with concentrated ownership structures. It also provides important and novel evidence for policymakers, investors, and business owners, particularly for firms with different ownership and management structures.
Individual and Neighborhood Level Predictors of Children’s Exposure to Residential Greenspace
Authors: Hazlehurst Marnie F. , Hajat Anjum , Szpiro Adam A. , Tandon Pooja S. , Kaufman Joel D. , Loftus Christine T. , Bush Nicole R. , LeWinn Kaja Z. , Hare Marion E. , Sathyanarayana Sheela , Karr Catherine J. 
Published: March 2024

AbstractInequities in urban greenspace have been identified, though patterns by race and socioeconomic status vary across US settings. We estimated the magnitude of the relationship between a broad mixture of neighborhood-level factors and residential greenspace using weighted quantile sum (WQS) regression, and compared predictive models of greenspace using only neighborhood-level, only individual-level, or multi-level predictors. Greenspace measures included the Normalized Difference Vegetation Index (NDVI), tree canopy, and proximity of the nearest park, for residential locations in Shelby County, Tennessee of children in the CANDLE cohort. Neighborhood measures include socioeconomic and education resources, as well as racial composition and racial residential segregation. In this sample of 1012 mother–child dyads, neighborhood factors were associated with higher NDVI and tree canopy (0.021 unit higher NDVI [95% CI: 0.014, 0.028] per quintile increase in WQS index); homeownership rate, proximity of and enrollment at early childhood education centers, and racial composition, were highly weighted in the WQS index. In models constrained in the opposite direction (0.028 unit lower NDVI [95% CI: − 0.036, − 0.020]), high school graduation rate and teacher experience were highly weighted. In prediction models, adding individual-level predictors to the suite of neighborhood characteristics did not meaningfully improve prediction accuracy for greenspace measures. Our findings highlight disparities in greenspace for families by neighborhood socioeconomic and early education factors, and by race, suggesting several neighborhood indicators for consideration both as potential confounders in studies of greenspace and pediatric health as well as in the development of policies and programs to improve equity in greenspace access.
Ginsenoside Rg1 relieves rat intervertebral disc degeneration and inhibits IL-1β-induced nucleus pulposus cell apoptosis and inflammation via NF-κB signaling pathway
Authors: Yu Lei , Hao Ying-Jie , Ren Zhi-Nan , Zhu Guang-Duo , Zhou Wei-Wei , Lian Xu , Wu Xue-Jian 
Published: March 2024

AbstractThe study aimed to investigate the effect of ginsenoside Rg1 on intervertebral disc degeneration (IVDD) in rats and IL-1β-induced nucleus pulposus (NP) cells, and explore its underlying mechanism. Forty IVDD rat models were divided into the IVDD group, low-dose (L-Rg1) group (intraperitoneal injection of 20 mg/kg/d ginsenoside Rg1), medium-dose (M-Rg1) group (intraperitoneal injection of 40 mg/kg/d ginsenoside Rg1), and high-dose (H-Rg1) group (intraperitoneal injection of 80 mg/kg/d ginsenoside Rg1). The pathological change was observed by HE and safranin O-fast green staining. The expression of IL-1β, IL-6, TNF-α, MMP3, aggrecan, and collagen II was detected. The expression of NF-κB p65 in IVD tissues was detected. Rat NP cells were induced by IL-1β to simulate IVDD environment and divided into the control group, IL-1β group, and 20, 50, and 100 µmol/L Rg1 groups. The cell proliferation activity, the apoptosis, and the expression of IL-6, TNF-α, MMP3, aggrecan, collagen II, and NF-κB pathway–related protein were detected. In IVDD rats, ginsenoside Rg1 improved the pathology of IVD tissues; suppressed the expression of IL-1β, IL-6, TNF-α, aggrecan, and collagen II; and inhibited the expression of p-p65/p65 and nuclear translocation of p65, to alleviate the IVDD progression. In the IL-1β-induced NP cells, ginsenoside Rg1 also improved the cell proliferation and inhibited the apoptosis and the expression of IL-6, TNF-α, aggrecan, collagen II, p-p65/p65, and IκK in a dose-dependent manner. Ginsenoside Rg1 alleviated IVDD in rats and inhibited apoptosis, inflammatory response, and ECM degradation in IL-1β-induced NP cells. And Rg1 may exert its effect via inhibiting the activation of NF-κB signaling pathway.
Prediction of antioxidant capacity in faba bean from individual phenolic constituents
Authors: Johnson Joel B. , Kazak Anatoliy , Gallini Nadezhda , Rudenko Marina , Naiker Mani 
Published: March 2024

AbstractThe relationship between individual phytochemical constituents and overall antioxidant capacity or total phenolic content (TPC) is poorly understood in faba bean. This study used a range of linear and nonlinear regression techniques to investigate whether the antioxidant capacity and TPC of 60 faba bean samples (flour and methanolic extracts) could be predicted from 12 individual compounds (10 common polyphenols and 2 alkaloid glycosides) measured in the same samples. Nonlinear regression using machine learning with a Radial Basis Function showed the best performance for antioxidant and TPC prediction across all sample types, while multiple linear regression allowed moderately accurate predictions in most sample matrices. Improved performance metrics were seen for the methanolic extracts compared to the flour samples. The strongest predictors of antioxidant activity in the multiple linear regression models were protocatechuic acid, p-hydroxybenzoic acid, and ferulic acid, suggesting that these compounds are particularly important contributors to the high antioxidant activity of faba bean. Understanding the relationship between individual constituents and the antioxidant capacity may help food technologists and plant breeders develop faba bean products with maximal health benefits.
Coupling of the immersed boundary and Fourier pseudo-spectral methods applied to solve fluid–structure interaction problems
Authors: Nascimento Andreia Aoyagui , Mariano Felipe Pamplona , da Silveira Neto Aristeu , Padilla Elie Luis Martínez 
Published: March 2024

AbstractThe current manuscript addresses fluid–structure interaction (FSI) problems to the analysis of vortex-induced vibration (VIV), employing the methodology designated as IMERSPEC2D. The approach seamlessly integrates the Fourier pseudo-spectral method (FPSM) and the immersed boundary method (IBM) to solve the Navier–Stokes (NS) and continuity equations. Simultaneously, the effects of cylindrical structure, involving 1 and 2 degrees of freedom (d.o.f.) are simulated, by incorporating structural motion equations into NS via the IBM source term and implementing a two-way FSI algorithm. In the paper are presented the comparison of low and high-order temporal integration methods applied to solve the dynamic behavior of the structure and the dimensionless of the cylinder’s structural motion equations, resulting in an increase in computational time step from 1E($$-9$$

-
9

) to 1E($$-3$$

-
3

). Validation results to refined mesh simulations include the accurate representation of the lock-in phenomenon to simulations of 1 d.o.f. obtaining the range between reduced velocity 5.456 and 5.568 and the maximal amplitude is 0.352. Notably, the eight-shape pattern of the 2 d.o.f. cylinder displacement is obtained and the formation of C2S wake patterns is achieved, as presented by other authors. In conclusion, the dimensionless approach reduces computational time, while the high-order both of IMERSPEC methodology and time advancement integration to FSI improve the results of the cylinder’s motion and alters distinct vortex shedding patterns in fluid dynamics.