bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between Colonoscopy Sedation Type and Polyp Detection: A Registry-based Cohort Study
Authors: Quaye Aurora N. , Hisey William M. , Mackenzie Todd A. , Robinson Christina M. , Richard Janelle M. , Anderson Joseph C. , Warters Robert D. , Butterly Lynn F. 
Published: April 2024

Background
Colorectal cancer is a leading cause of cancer-related death. Adenomas and serrated polyps are precursors of colorectal cancer, with serrated polyps being more difficult to detect during colonoscopy. The relationship between propofol use and polyp detection remains unclear. The authors investigated the association of propofol-based versus mild–moderate sedation on adenoma and serrated polyp detection during colonoscopy.

Methods
This retrospective cohort study used observational data from the New Hampshire Colonoscopy Registry. Patients aged greater than 50 yr with screening or surveillance colonoscopies between January 1, 2015, and February 28, 2020, were included. Exclusions were diagnostic examinations, no sedation, missing pathology data, and poor bowel preparation. Multivariate logistic regression was used to evaluate differences in polyp detection between propofol and moderate sedation in the full sample while adjusting for covariates. Propensity score adjustment and clustering at the endoscopist level were used in a restricted sample analysis that included endoscopists and facilities with between 5% and 95% propofol sedation use.

Results
A total of 54,063 colonoscopies were analyzed in the full sample and 18,998 in the restricted sample. Serrated polyp prevalence was significantly higher using propofol (9,957 of 29,312; 34.0% [95% CI, 33.4 to 34.5%]) versus moderate sedation (6,066 of 24,751; 24.5% [95% CI, 24.0 to 25.1%]) in the full sample and restricted samples (1,410 of 4,661; 30.3% [95% CI, 28.9 to 31.6%] vs. 3,690 of 14,337; 25.7% [95% CI, 25.0 to 26.5%]). In the full sample multivariate logistic regression, propofol was associated with higher neoplasm (adjusted odds ratio, 1.25 [95% CI, 1.21 to 1.29]), adenoma (odds ratio, 1.07 [95% CI, 1.03 to 1.11]), and serrated polyp detection (odds ratio, 1.51 [95% CI, 1.46 to 1.57]). In the restricted sample using inverse probability of treatment weighted propensity score adjustment and clustering at the endoscopist level, an attenuated but statistically significant effect size was observed for serrated polyps (odds ratio, 1.13 [95% CI, 1.07 to 1.19]), but not for adenomas (odds ratio, 1.00 [95% CI, 0.95 to 1.05]) or any neoplastic lesion (odds ratio, 1.03 [95% CI, 0.98 to 1.08]).

Conclusions
Propofol sedation during colonoscopy may be associated with improved detection of serrated polyps, but not adenomas.

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Comparing serial and current liver stiffness measurements to predict decompensation in compensated advanced chronic liver disease patients
Authors: Wong Yu Jun , Chen Vincent L. , Abdulhamid Asim , Tosetti Giulia , Navadurong Huttakan , Kaewdech Apichat , Cristiu Jessica , Song Michael , Devan Pooja , Tiong Kai Le Ashley , Neo Jean Ee , Prasoppokakorn Thaninee , Sripongpun Pimsiri , Stedman Catherine Ann Malcolm , Treeprasertsuk Sombat , Primignani Massimo , Ngu Jing Hieng , Abraldes Juan G. 
Published: April 2024

Background and Aims:
The utility of serial liver stiffness measurements (LSM) to predict decompensation in patients with compensated advanced chronic liver disease (cACLD) remains unclear. We aimed to validate whether comparing serial LSM is superior to using the current LSM to predict liver-related events (LRE) in patients with cACLD.

Approach and Results:
In this retrospective analysis of an international registry, patients with cACLD and serial LSM were followed up until index LRE. We compared the performance of both the dynamic LSM changes and the current LSM in predicting LRE using Cox regression analysis, considering time zero of follow-up as the date of latest liver stiffness measurement. Overall, 480 patients with cACLD with serial LSM were included from 5 countries. The commonest etiology of cACLD was viral (53%) and MASLD (34%). Over a median follow-up of 68 (IQR: 45-92) months, 32% experienced a LSM decrease to levels below 10kPa (resolved cACLD) and 5.8% experienced LRE. Resolved cACLD were more likely to be non-diabetic and had better liver function. While a higher value of the current LSM was associated with higher LREs, LSM changes over time (LSM slope) were not associated with LRE. In multivariable Cox regression, neither the prior LSM nor the LSM slope added predictive value to latest liver stiffness measurement.

Conclusions:
Once the current LSM is known, previous LSM values do not add to the prediction of LREs in patients with cACLD.
SUPRACHOROIDAL TRIAMCINOLONE ACETONIDE FOR REFRACTORY POSTOPERATIVE CYSTOID MACULAR EDEMA
Authors: Momenaei Bita , Pandit Saagar A. , Wang Kristine Y. , Wakabayashi Taku , Hsu Jason , Regillo Carl D. , Klufas Michael A. , Xu David , Cohen Michael N. , Garg Sunir J. , Kuriyan Ajay E. , Yonekawa Yoshihiro 
Published: April 2024

Purpose:
To investigate outcomes of suprachoroidal triamcinolone acetonide (XIPERE, Bausch + Lomb) for the treatment of refractory postoperative cystoid macular edema.

Methods:
Medical records of patients receiving suprachoroidal triamcinolone acetonide for postoperative cystoid macular edema were reviewed. Primary outcomes were visual acuity and central foveal thickness.

Results:
A total of 32 eyes from 32 patients with a median (interquartile range) follow-up duration of 6 (2–7) months and 1 (1–2) suprachoroidal triamcinolone acetonide injection were included; 19 (59.4%) had a history of vitrectomy. The median (interquartile range) central foveal thickness decreased from 492 (379–629) µm to 267 (187–388) µm at 1 month (P < 0.001), 362 (218–521) µm at 3 months (P = 0.005), and 339 (206–514) µm at the final visit (P < 0.001). The median logarithm of the minimal angle of resolution visual acuity improved from 0.65 (0.48–0.97, 20/89) at baseline to 0.54 (0.35–0.88, 20/69) (P = 0.058) at 1 month, 0.54 (0.33–0.84, 20/69) at 3 months (P = 0.121), and 0.60 (0.33–0.88, 20/80) at the final visit (P = 0.021). Vitrectomized eyes had similar findings. Six eyes (18.8%) developed elevated intraocular pressure (>24 mmHg) (range: 25–49 mmHg) with a median intraocular pressure elevation of 13.5 mmHg compared with baseline, and all had prior glaucoma or ocular hypertension.

Conclusion:
Suprachoroidal triamcinolone acetonide reduced macular edema and improved vision in refractory postoperative cystoid macular edema, including vitrectomized eyes. Intraocular pressure should be monitored, especially in those with a history of glaucoma or ocular hypertension.
Hematuria Due to Possible Histoplasma-Associated Urinary Bladder Pseudotumor With Negative Serologic and Urine Antigen Testing
Authors: Aggarwal Abhimanyu , Mills Corey , Frankenberger Kyle , Greenstein Adam , Nelson Benjamin , Hatem Fadi , Blue Deborah E. , Wheat L. Joseph , Yamshchikov Alexandra 
Published: April 2024

Abstract

Histoplasma capsulatum is a ubiquitous dimorphic fungus causing multiple infectious syndromes, ranging from subclinical to severe disseminated disease. We present an unusual case of hematuria due to pedunculated urinary bladder mass in an immunocompetent host. Although the gold standard for diagnosis of histoplasmosis is through demonstration of characteristic yeast forms on histopathologic examination of infected tissue, or observation of typical mycelial growth in culture of clinical specimens, investigational multiplex polymerase chain reaction of formalinized tissue was helpful in this case due to conflicting serologic testing, equivocal morphologic findings on histopathologic examination and, surprisingly, a negative urine Histoplasma antigen despite anatomically proximal location within the urinary bladder. Although antigen immunoassay and serology are commonly used proxy diagnostics in Histoplasma-associated disease, varying performance characteristics in certain disease states, such as cases of locally proliferative infection mimicking neoplastic growth similar to this report, may lead to elusive diagnosis.
Development and Testing of the Relational and Structural Components of Innovativeness Across Academia and Practice for Healthcare Progress Scale
Authors: Joseph M. Lindell , Williams Michele , Reinke Karl , Bair Heather , Chae Sena , Hanrahan Kirsten , St. Marie Barbara , Jenkins Peggy , Albert Nancy M. , Gullatte Mary M. , Rogers Darlene M. , Swan Beth Ann , Holden Tina , Woods Elizabeth , DeGuzman Pamela B. , DeGennaro Gina , Marshall David , Hein Maria , Perkhounkova Yelena , Huber Diane L. 
Published: April 2024

OBJECTIVEUsing data from 5 academic-practice sites across the United States, researchers developed and validated a scale to measure conditions that enable healthcare innovations.BACKGROUNDAcademic-practice partnerships are a catalyst for innovation and healthcare development. However, limited theoretically grounded evidence exists to provide strategic direction for healthcare innovation across practice and academia.METHODSPhase 1 of the analytical strategy involved scale development using 16 subject matter experts. Phase 2 involved pilot testing the scale.RESULTSThe final Innovativeness Across Academia and Practice for Healthcare Progress Scale (IA-APHPS) consisted of 7 domains: 3 relational domains, 2 structural domains, and 2 impact domains. The confirmatory factor analysis model fits well with a comparative fit index of 0.92 and a root-mean-square error of approximation of 0.06 (n = 477).CONCLUSIONAs the 1st validated scale of healthcare innovation, the IA-APHPS allows nurses to use a diagnostic tool to facilitate innovative processes and outputs across academic-practice partnerships.
Which Sit-to-Stand Test Best Differentiates Functional Capacity in Older People?
Authors: Cruz-Montecinos Carlos , Torres-Castro Rodrigo , Otto-Yáñez Matías , Barros-Poblete Marisol , Valencia Carola , Campos Alex , Jadue Leticia , Barros Marcela , Solis-Navarro Lilian , Resqueti Vanessa 
Published: April 2024

Abstract
The sit-to-stand test provides insight into age-related functional capacity; however, there are various variants of sit-to-stand, and we do not know which of these better discriminates against age-related functional capacity. Our study aimed to compare the age-related functional capacity in older people by evaluating sit-to-stand power variants, using young individuals as a reference. A cross-sectional study was conducted in 102 adults (57 women) aged 60–80 and 105 adults (54 women) aged 20–30. Participants performed five times sit-to-stand (5 sit-to-stand), 30-second sit-to-stand, and 1-min sit-to-stand. Z scores were obtained for each sit-to-stand variant using power (W), relative (W/kg), and allometric (W/m2) normalization methods. A mixed repeated-measures analysis of variance assessed the interactions among the sit-to-stand variants, normalization methods, sex, physical activity, and tobacco history. A significant interaction between sit-to-stand variants, normalization methods, and sex (P = 0.002) was found. The mean effect of sit-to-stand variants revealed that the 1-min sit-to-stand had the lowest Z score (P < 0.05). Significant variations were observed between sit-to-stand variants in all normalization methods for women (P < 0.001). However, in men, only the difference between 5 sit-to-stand and 1-min sit-to-stand remained consistent across normalization methods (P < 0.05). Our findings highlight the efficacy of 1-min sit-to-stand in distinguishing age-related functional capacity over the other sit-to-stand tests, especially in women.
Radionuclide Therapy With 177Lu-PSMA in a Patient With Hepatocellular Carcinoma
Authors: Pretet Valentin , Giraudet Anne Laure , Vergnaud Laure , Paquet Emilie , Kryza David 
Published: April 2024

Abstract
A 69-year-old man diagnosed with progressive bone metastatic castration-resistant prostate adenocarcinoma and concurrent alcoholic cirrhosis with multiple hepatocellular carcinoma (HCC) nodules was referred to our nuclear medicine service for 177Lu-PSMA-617 therapy. The patient’s pretreatment screening using 68Ga-PSMA-11 PET/CT revealed high prostate-specific membrane antigen expression in both prostatic and HCC lesions. The patient underwent 2 doses of 177Lu-PSMA-617. Subsequent imaging assessments with 68Ga-PSMA-11 PET/CT and hepatic MRI indicated progressive HCC nodules, while showing a partial response in prostatic bone metastases. Positive clinical and biological responses were observed only in prostatic disease, but not in HCC nodules.
Worms of change: anthropogenic disturbance changed the ectoparasite community structure of Lake Victoria cichlids
Authors: Gobbin Tiziana , Van Steenberge Maarten , Vranken Nathan , Vanhove Maarten PM 
Published: April 2024

AbstractHost-parasite interactions increase the complexity, and thus robustness and resilience, of an ecosystem. This role is particularly relevant in times of global change. Environmental changes cause biodiversity loss and shifts in community compositions of free-living organisms, but how these changes affect parasite communities is still unclear. We tested how parasites respond to anthropogenic perturbations, using the case of Lake Victoria (East Africa), after 40 years of their onset. Lake Victoria experienced multiple human-induced invasions (e.g. Nile perch) and eutrophication that heavily affected haplochromine cichlid fishes (whose species richness decreased from 500 to 250 species in a decade). We compared gill macroparasite communities of 13 haplochromine species before and after perturbations, using historical and recent fish collections. The host-parasite network re-arranged, with few emerging and few disappearing host-parasite combinations, in a way that reduced stability. The host range of parasites, which is linked to resilience ability, decreased and thus we expect a decreased resilience ability in the future. We also found a decrease in infection parameters, co-infection occurrence, and biodiversity indices highlighting the urgent need of a conservation plan for wildlife parasites, to preserve their ecosystem services in face of global change. This study serves as a proof-of-concept of how often-overlooked aspects of host-parasite interactions provide a tool to monitor the health status of an ecosystem.
Harnessing the Eccrine Sweat Glands for the Management of Interdialytic Weight Gain – A Pilot Study
Authors: Armaly Zaher A. , Nitzan Yaacov , Chernin Gil , Aronson Doron 
Published: April 2024

ABSTRACTBackgroundHemodialysis patients are susceptible to excess volume accumulation, particularly over the 2-day interval (long interdialytic gap), resulting in higher interdialytic weight gain (IDWG).MethodsWe employed a novel device designed to enhance fluid and salt loss by activating of the eccrine sweat glands to treat IDWG. Patients eligible for the study were undergoing regular hemodialysis for ≥3 months, without residual renal function, and with IDWG (as a percentage of IDWG/dry body weight) ≥2.5%. Treatments were administered at the patient’s home. The primary performance endpoint was differences in weight gain over long interdialytic period with the device compared to the control period. Secondary exploratory endpoints included the need for ultrafiltration (UF) rate > 10 mL/kg/h in the post-interval dialysis.ResultsFive patients were enrolled into the pilot study (age range 26 to 69 years, 3 women). The hourly mean weight loss from sweat was 186 ± 45 gr/h. The average procedure length was 4.5 hours with an average fluid loss of 899 ± 283 gr per procedure. The average least-squares mean absolute difference between the control and treatment periods was -2.0%; (95% confidence interval [CI], -2.9% to -1.2%, P<0001). The reduction in IDWG was associated a reduction in UF rates, with a least-squares mean difference of -3.2 mL/Kg/min [95% CI -4.6 to -1.8] between the control and treatment periods (P<0.001), resulting in a safe UF rate (<10 mL/Kg/min) in all post-treatment sessions.ConclusionEnhancing sweat rate mitigated IDWG in hemodialysis patients. Together with trice weekly HD, this therapy more closely approximates the capacity of the native kidney to regulate extracellular volume and solute composition, similar to patients with substantial residual kidney function.
The behaviors of Indonesian domestic ecotourists using a Rasch analysis
Authors: Setiawan Budi , Muawanah Umi , Maulana Addin , Khoiriyani Fauziah , Tri Astuti Marhanani , Hakim Imam Nur 
Published: April 2024

Purpose
This study aims to analyze the capacity of ecotourists to exhibit behavior that aligns with the ecotourist scale using the Rasch model measurement.

Design/methodology/approach
The data was gathered using an online survey incorporating the five tenets of ecotourism using a seven-point rating scale on domestic tourists in Indonesia. Descriptive statistics, cross-tabulation and Rasch model measurement were used to analyze the data.

Findings
The ecotourist identification scale measurement items were reliable and satisfactory. The most challenging behavior for ecotourists was using the services of a tour guide who was concerned about the environment. Meanwhile, respecting cultural differences around the tourist destination was the most accessible behavior. Most respondents demonstrated a fit response pattern and satisfactorily met the validity and reliability criteria.

Research limitations/implications
This study did not compare ecotourists’ ability to behave by the type of conservation visited as its limitation. However, it provides a significant methodological contribution to developing a measurement of ecotourist behavior implemented in well-established behavioral theories.

Practical implications
Integrating ecotourism into education, incentivizing eco-friendly tourism practices, promoting awareness, supporting local businesses, respecting local values and ensuring safe travels.

Originality/value
To the best of the authors’ knowledge, this study is the first of its kind to be conducted in Indonesia. It uses a unique and innovative method to reveal the unobserved variables in ecotourists’ behavior. The findings confirm that tourists’ behaviors align with the five tenets of ecotourism.
Analysis of market environment for smart grid technology investments via facial action coding system-enhanced hybrid decision-making model
Authors: Yuksel Serhat , Dincer Hasan , Mikhaylov Alexey 
Published: April 2024

Purpose
This paper aims to market analysis on the base many factors. Market analysis must be done correctly to increase the efficiency of smart grid technologies. On the other hand, it is not very possible for the company to make improvements for too many factors. The main reason for this is that businesses have constraints both financially and in terms of manpower. Therefore, a priority analysis is needed in which the most important factors affecting the effectiveness of the market analysis will be determined.

Design/methodology/approach
In this context, a new fuzzy decision-making model is generated. In this hybrid model, there are mainly two different parts. First, the indicators are weighted with quantum spherical fuzzy multi SWARA (M-SWARA) methodology. On the other side, smart grid technology investment projects are examined by quantum spherical fuzzy ELECTRE. Additionally, facial expressions of the experts are also considered in this process.

Findings
The main contribution of the study is that a new methodology with the name of M-SWARA is generated by making improvements to the classical SWARA. The findings indicate that data-driven decisions play the most critical role in the effectiveness of market environment analysis for smart technology investments. To achieve success in this process, large-scale data sets need to be collected and analyzed. In this context, if the technology is strong, this process can be sustained quickly and effectively.

Originality/value
It is also identified that personalized energy schedule with smart meters is the most essential smart grid technology investment alternative. Smart meters provide data on energy consumption in real time.
From hierarchical to matrix structure: tensions in negotiating shared leadership configurations
Authors: Gibeau Emilie 
Published: April 2024

PurposeDespite much attention being devoted to shared leadership, the negotiation of such arrangements remains underexplored. In parallel, the revival of interest in matrix structures reveals their challenges but neglects the dynamics of shared leadership. In this case study, the author analyzes the tensions experienced by senior managers of a healthcare organization transitioning from a hierarchical to matrix structure as they negotiate their leadership roles in this new arrangement.Design/methodology/approach The author interviewed 16 senior managers, observed their meetings and analyzed documents. These data were combined with secondary data including previous interviews and observations of this top leadership team. The author then conducted an inductive data analysis.Findings The author's analysis reveals that the tensions experienced by senior managers as they negotiate their roles reflect the co-existence of leadership surpluses (too much leadership) and deficits (too little leadership) in matrix organizations. The author argues that surpluses and deficits are not mutually exclusive but are interrelated and shows how leadership surpluses can create leadership deficits.Practical implicationsThe author’s findings suggest that in contexts of leader abundance, actors should explore leadership voids. Particular attention should be paid to incidents of intrusion and exclusion, moments of transition and intense role negotiation, as those contexts are particularly conducive to leadership deficits.Originality/valueWhile previous work on matrix structures focuses on leadership surpluses, the author discusses leadership deficits. The author explores how more leaders do not necessarily mean more leadership, but instead how more leaders may result in leadership voids.
Guidelines to promote sustainable transport in higher education universities: a bibliometric and systematic review
Authors: Oestreich Letícia , Neuenfeldt Júnior Álvaro , Ruiz-Padillo Alejandro 
Published: April 2024

Purpose
Unplanned urban mobility causes negative effects on the population and the environment. This study aims to understand how higher education institutions (HEIs) are managing the transportation issues related to their activities and how they are implementing actions towards more sustainable practices in this regard.

Design/methodology/approach
A systematic review and bibliometric analysis were performed using the Proknow-C method, and the bibliographic portfolio was evaluated to answer guiding questions about distribution of articles over the years and around the world, the most relevant and frequent topics, the travel behavior of university life and the main methodologies used. The meta-analysis was modeled using a programming language in R to execute Bibliometrix package.

Findings
Sharing systems, active transport, public transport, urban planning, car parking management and travel behavior are the most relevant topics related to sustainable mobility in HEIs. Different strategies to reduce car use are adopted, and the geographic location of the university and the availability of housing and shopping services in close proximity directly influence travel patterns. As a result, seven guidelines and strategic actions associated were proposed to promote the engagement of institutions in the development of sustainable transport and guide future studies about new solutions to promote sustainable university commutes.

Originality/value
This paper presents a new perspective by performing a critical literature review based on the experiences reported by several isolated studies on the subject. Initiatives of sustainable transport guidelines can be used by academics, urban planners, higher education administrators and other stakeholders to make universities more environmentally friendly, inclusive and accessible.