bluuebunny/crossref_metadata_2025_split huggingface dataset:
MORFOMETRI DAN BATIMETRI DANAU PALAS ASRI KECAMATAN MEDANG DERAS KABUPATEN BATUBARA
Authors: Leidonald Rusdi , Rambe Ade Septiya Jumiani , Muhtadi Ahmad , Fadhilah Amanatul 
Published: April 2024

Morfometri danau merupakan karakteristik fisik dari badan danau yang dapat menggambarkan berbagai potensinya. Tujuan dari penelitian ini adalah untuk mengetahui aspek morfometri dan batimetri di perairan Danau Palas Asri Kecamatan Medang Deras Kabupaten Batubara. Penelitian ini dilakukan pada bulan Oktober sampai November 2022. Pengambilan data yang dilakukan pada penelitian ini adalah data keliling danau, data kedalaman, panjang dan lebar danau, debit air serta kualitas air. Data-data tersebut diolah menggunakan Arcmap. Hasil dari penelitian ini adalah Danau Palas Asri (Danau A dan Danau B) secara berturut-turut memiliki luas 33.231 dan 26.544 , panjang maksimum 337,29 m dan 340,26 m, lebar maksimum 130,42 m dan 119,40 m serta panjang keliling danau 1.152,27 m dan 859,63 m. kedalaman maksimum 2,5 m dan 2,8 m, kemiringan rata-rata 4,72% dan 4,69%. Volume air danau yang dapat dimanfaatkan sebanyak 49.938,74 dan 44.062,64 dengan waktu tinggal air sekitar 20-21 hari dan 23-24 hari. Parameter kualitas fisika kimia air Danau Palas Asri (Danau A dan Danau B) secara berturut-turut adalah memiliki rata-rata Total Suspended Solid (TSS) 10,66 mg/L dan 9,33 mg/L, Total Dissolved Solid (TDS) 85,36 mg/L dan 67,96 mg/L, Daya Hantar Listrik (DHL) 15,36 S/cm dan 11,63 S/cm, Fosfat 0,10 mg/L dan 0,11 mg/L. Nilai TSI berkisar 16,05 - 21,10 status trofik Danau Palas Asri tergolong oligotrofik yaitu kondisi produktivitas dan unsur hara rendah.
Kata Kunci : Batimetri, danau, kesuburan perairan, morfometri danau,
NAMA HARAM TAPI PRODUK HALAL: PANDANGAN DARI PERSPEKTIF UNDANG-UNDANG MALAYSIA DAN HUKUM ISLAM
Authors: Md Ariffin Mohd Farhan , Mohamad Riza Nurul Syahadah , Hamdan Mohammad Naqib , Md Radzi Mohd Shahril Nizam , Abdul Rahman Najwa Hanani , Abdul Hamid Mohammad Fahmi 
Published: April 2024

The nomenclature of a subject matter represents the inherent characteristics and attributes of an item. In the context of the food sector, there exists a strong correlation between the name and commercial impact of a particular product. The choice of the name of a product names is significant for purposes of branding and marketing. Nevertheless, some parties combine illegal and permissible elements in the process of choosing product names, such as “hotdog”, “beer”, and others. The combination of brand names for halal products has become a subject of contention among Muslim scholars and customers, due to the ambiguity surrounding their halal status. This study examines the legal and Islamic implications of associating a halal product with a name that imputes prohibited elements from the perspective of the evidences found in al-Quran and hadith and the country's halal regulatory framework and the Shariah as a whole. Library research and content analysis are employed as methodologies to obtain relevant information on the subject matter of this research. The results of this study indicate that the definition of halal, as outlined in the halal legislation of this country is limited and is only restricted to food ingredients, products and services. Further, there exists a loophole in the powers conferred upon the relevant agencies to ascertain the suitability of the nomenclature to be in accordance with the principles of the Shariah, thereby ensuring adherence to the concept of halalan tayyiban in its entirety for each halal product.

Abstrak

Nama melambangkan identiti sesuatu benda. Dalam industri makanan, hal ini sangat berkait rapat dengan pengaruh komersial bagi satu-satu produk. Berikutan itu, pemilihan nama produk penting bagi tujuan penjenamaan dan pemasaran. Walau bagaimanapun, terdapat pihak yang menggandingkan unsur-unsur haram dan halal dalam pemilihan nama produk seperti Hotdog, Beer dan sebagainya. Penggabungan nama seperti ini bagi produk halal menjadi pertikaian dalam kalangan ulama dan pengguna kerana mendatangkan kekeliruan terhadap status halalnya. Sehubungan dengan itu, kajian ini membahas status penamaan sesuatu produk halal yang digandingkan dengan nama yang mempunyai unsur haram dari perspektif kerangka nas al-Quran dan hadis, perundangan halal negara dan hukum Islam. Kajian kepustakaan dan analisis dokumen digunakan untuk mendapatkan maklumat kajian. Hasil kajian mendapati konsep halal yang ditakrifkan di bawah kerangka perundangan halal negara sangat terhad dan hanya terpakai kepada kandungan makanan, barangan atau perkhidmatan sahaja. Malahan terdapat juga kelompongan terhadap kuasa agensi yang berkaitan dalam memastikan penggunaan nama yang bersesuaian yang selari dengan prinsip syariah dalam menjamin pematuhan konsep halalan tayyiban secara kolektif bagi satu-satu produk halal.
Anatomy of the Cystic Duct – Factors Affecting the Stasis of Bile and Formation of Gall Stones
Authors: Rahman Khalilur , Anwar Selina , Begum Anjum Ara , Saha Narayan Chandra , Ahmed Neaz , Yesmin Shamima 
Published: April 2024

Background: An increasing incidence of liver and gall bladder diseases bring about an increasing necessity of their precise diagnosis. Unrecognized anatomic variants of the extrahepatic billiary apparatus may cause confusion on imaging studies and complicate subsequent surgical, endoscopic, and percutaneous procedures. Although much have been written about the normal anatomy and related diseases of the gallbladder and biliary tract but no available data have been found about the variations of the cystic duct in Bangladeshi people. This study was aimed at determining the anatomical variations of gross morphological features of cystic duct in relation to age and sex in Bangladeshi people as well as to find out any congenital anomalies of the extrahepatic biliary system.
Materials and methods: A cross sectional descriptive type of study was carried out at the Department of Anatomy, Rangpur Medical College, Rangpur. The study was conducted on postmortem gallbladder with cystic duct from 60 unclaimed dead bodies of Bangladeshi people. Of which, 32 were male specimens and 28 were female specimens. The specimens were divided into two groups according to age, young age group A (20-40 years) and elderly age group B (41-65 years). The length and diameter of cystic duct was measured and number of valves in cystic duct was counted. Comparison was done between male and female of two age groups by Student’s unpaired‘t’ test.
Results: The length of the cystic duct showed a significantly higher value in elderly male than younger male and corresponding f emale groups of similar age. The number of spiral valves showed similar values in both sexes.
Conclusion: No relationship between cystic duct length, diameter and number of spiral valves with different sex and different age could be established in this study.
Bangladesh Journal of Anatomy July 2015, Vol. 13, No. 2, pp. 32-36
Analisis Peramalan Permintaan Jaket Inalcafa pada Produk Pria dengan Metode Double Moving Average
Authors: Kusuma Harun Indra , Saputra Ridwan 
Published: April 2024

Produk jaket Inalcafa memiliki tiga jenis variasi, antara lain untuk pria, wanita dan anak-anak. Pada penelitian ini, peneliti mencoba untuk meramalkan jumlah permintaan jaket inalcafa pada variasi produk pria selama enam bulan kedepan. Dengan meramalkan jumlah permintaan jaket Inalcafa, dapat memberikan informasi jumlah permintaan jaket Inalcafa pada variasi produk pria di periode berikutnya. Metode peramalan yang kami lakukan perhitungan antara lain metode double moving average. Setelah peneliti melakukan perhitungan peramalan dari metode double moving average, selanjutnya peneliti menetapkan batas kelas atas, nilai tengah dan batas kelas bawah berdasarkan data penjualan 24 bulan sebelumnya.Terakhir peneliti melakukan perhitungan moving range untuk menunjukkan perbandingan nilai data aktual dengan nilai peramlan. Setelah peneliti melakukan perhitungan peramlan dari metode double moving average, didapatkan nilai error sebesar 6,77%. Jumlah produksi yang diramalkan selama 6 bulan berikutnya memiliki rata-rata sebanyak 34,67 buah dari jaket variasi produk pria yang diproduksi.
PENGARUH TEKNIK ART THERAPY TERHADAP EMOSI MARAH PADA SISWA KELAS VIII DI SMPN 5 PRAYA
Authors: Astuti Farida Herna 
Published: April 2024

Art therapy adalah sebuah terapi yang menggabungkan seni dan psikologi untuk membantu individu mengatasi masalah emosional dan psikologis yang mengalami trauma, penyakit, serta orang-orang yang mencari pengembangan pribadi.Emosi marah adalah salah satu dari berbagai jenis emosi manusia yang timbul sebagai respons terhadap suatu situasi atau peristiwa yang memicu perasaan kemarahan atau amarah.Tujuan penelitian ini adalah untuk mengetahui Pengaruh Teknik Art Therapy Terhadap Emosi Marah Pada Siswa Kelas VIII di SMPN 5 Praya Tahun Pelajaran 2022/2023. Desain penelitian ini yaitu one group pre-test – post-test design. Populasi dalam penelitian ini adalah siswa siswa kelas VIII SMPN 5 Praya yang berjumlah 64 siswa, dan sampel dalam penelitian ini sebanyak 7 orang siswa yang memiliki tingkat emosi marah yang tinggi berdasarkan hasil dari pre-test. Teknik pengumpulan data yang digunakan dalam penelitian ini yaitu purposive sampling. Metode pengumpulan data yang digunakan adalah angket sebagai metode pokok, metode observasi, wawancara dan dokumentasi sebagai metode pelengkap. Analisis data menggunakan rumus t-test. Berdasarkan hasil analisis data, diperoleh nilai thitung sebesar (6,687), sedangkan untuk nilai ttabel pada taraf signifikansi 5% sebesar (2,447). Karena thitung lebih besar dari nilai ttabel (6,687 > 2,447), maka Ho ditolak dan Ha diterima. Jadi hasil penelitian ini menunjukkan ada Pengaruh Teknik Art Therapy Terhadap Emosi Marah Pada Siswa Kelas VIII Di SMPN 5 Praya.
Predictive value of the inconsistency between the residual and post-PCI QFR for prognosis in PCI patients
Authors: Chen Lihua , Zhong Jiaxin , Hong Ruijin , Chen Yuxiang , Li Beilei , Wang Laicheng , Yan Yuanming , Chen Lianglong , Chen Qin , Luo Yukun 
Published: April 2024

IntroductionTo investigate the prognostic value of the consistency between the residual quantitative flow ratio (QFR) and postpercutaneous coronary intervention (PCI) QFR in patients undergoing revascularization.MethodsThis was a single-center, retrospective, observational study. All enrolled patients were divided into five groups according to the ΔQFR (defined as the value of the post-PCI QFR minus the residual QFR): (1) Overanticipated group; (2) Slightly overanticipated group; (3) Consistent group; (4) Slightly underanticipated group; and (5) Underanticipated group. The primary outcome was the 5-year target vessel failure (TVF).ResultsA total of 1373 patients were included in the final analysis. The pre-PCI QFR and post-PCI QFR were significantly different among the five groups. TVF within 5 years occurred in 189 patients in all the groups. The incidence of TVF was significantly greater in the underanticipated group than in the consistent group (P = 0.008), whereas no significant differences were found when comparing the underanticipated group with the other three groups. Restricted cubic spline regression analysis showed that the risk of TVF was nonlinearly related to the ΔQFR. A multivariate Cox regression model revealed that a ΔQFR≤ −0.1 was an independent risk factor for TVF.ConclusionsThe consistency between the residual QFR and post-PCI QFR may be associated with the long-term prognosis of patients. Patients whose post-PCI QFR is significantly lower than the residual QFR may be at greater risk of TVF. An aggressive PCI strategy for lesions is anticipated to have less functional benefit and may not result in a better clinical outcome.
Effects of high-intensity interval exercise on arterial stiffness in individuals at risk for cardiovascular disease: a meta-analysis
Authors: Luo Ping , Wu Ruoshan , Gao Weifeng , Yan Weiyi , Wang Ruixue , Ye Yufang 
Published: April 2024

ObjectiveThe purpose of this meta-analysis was to investigate the effect of high-intensity interval training (HIIT) on arterial stiffness (AS) and vascular function in persons at high risk of cardiovascular disease (CVD).MethodsWe conducted a comprehensive search of randomized controlled trials (RCTs) published in electronic databases (PubMed, Web of Science, Cochrane, Embase, and Ebsco) since their inception through October 2023 to evaluate the effect of HIIT on AS and vascular function in persons at high risk for CVD. The weighted mean difference (WMD) and 95% confidence intervals (95% CI) were calculated, and heterogeneity was assessed using the I2 test.ResultsThis study included 661 participants from 16 studies. HIIT significantly reduced pulse wave velocity (PWV) in persons at high risk for CVD [weighted mean difference (WMD), −0.62; 95% CI, −0.86–−0.38; P &lt; 0.00001]. Subgroup analysis showed that the PWV improvement effect was better when the HIIT program was performed 2–3 times per week and the duration was controlled within 40 min [2–3 times, −0.67; 95% CI, −0.93–−0.41; P &lt; 0.00001; time of duration, ≤40 min, −0.66; 95% CI, −0.91–−0.41; P &lt; 0.00001]. HIIT significantly reduced systolic blood pressure (SBP, −5.43; 95% CI, −8.82–−2.04; P = 0.002), diastolic blood pressure (DPB, −2.96; 95% CI, −4.88–−1.04; P = 0.002), and resting heart rate (RHR, −4.35; 95% CI, −7.04–−1.66; P = 0.002), but had no significant effect on augmentation index (AIX, −2.14; 95% CI, −6.77–2.50; P = 0.37).ConclusionHIIT can improve PWV in high-risk individuals with CVD and reduce SBP, DBP, and RHR, but has no significant effect on AIX. HIIT can effectively improve AS and vascular function and can be recommended as an effective method to improve AS in high-risk persons with CVD.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier: CRD42023471593.
Decreasing lifetime prevalence of diabetes-related foot ulcers in Norway: repeated cross-sectional population-based surveys from the HUNT study (1995-2019)
Authors: Riise Hilde K. R. , Igland Jannicke , Graue Marit , Haugstvedt Anne , Østbye Truls , Søfteland Eirik , Hermann Monica , Carlsson Sofia , Åsvold Bjørn Olav , Iversen Marjolein M. 
Published: April 2024

Background and aimsDiabetes-related foot ulcers (DFU) are a persistent healthcare challenge, impacting both patients and healthcare systems, with adverse effects on quality of life and productivity. Our primary aim was to examine the trends in lifetime prevalence of DFU, as well as other micro- and macrovascular complications in the Trøndelag Health Study (HUNT) in Norway.MethodsThis study consists of individuals ≥20 years with diabetes participating in the population-based cross-sectional HUNT surveys (1995-2019). Prevalence ratios, comparing the lifetime prevalence of DFU and other relevant micro- and macrovascular complications between the HUNT surveys, were calculated using Poisson regression.ResultsThe lifetime prevalence (95% confidence interval (CI)) of a DFU requiring three or more weeks to heal was 11.0% (9.5-12.7) in HUNT2, 7.5% (6.3-8.8) in HUNT3 and 5.3% (4.4-6.3) in HUNT4. The decrease in DFU prevalence from 1995 to 2019 was observed in both men and women, for all age groups, and for both type 1 and type 2 diabetes. The highest lifetime prevalence of DFU was found among those with type 1 diabetes. The decrease in HbA1c from HUNT2 to HUNT4 did not differ between those with and without a DFU. The prevalence of chronic kidney disease (eGFR &lt;60 mL/min/1.73 m2 (eGFR categories G3-G5)) increased in both individuals with and without a DFU.ConclusionResults from the HUNT surveys show a substantial decline in the lifetime prevalence of DFU from 1995 to 2019.
Detection and characterization of copy number variation in three differentially-selected Nellore cattle populations
Authors: Benfica Lorena F. , Brito Luiz F. , do Bem Ricardo D. , de Oliveira Leticia F. , Mulim Henrique A. , Braga Larissa G. , Cyrillo Joslaine N. S. G. , Bonilha Sarah F. M. , Mercadante Maria Eugenia Z. 
Published: April 2024

Introduction: Nellore cattle (Bos taurus indicus) is the main beef cattle breed raised in Brazil. This breed is well adapted to tropical conditions and, more recently, has experienced intensive genetic selection for multiple performance traits. Over the past 43 years, an experimental breeding program has been developed in the Institute of Animal Science (IZ, Sertaozinho, SP, Brazil), which resulted in three differentially-selected lines known as Nellore Control (NeC), Nellore Selection (NeS), and Nellore Traditional (NeT). The primary goal of this selection experiment was to determine the response to selection for yearling weight (YW) and residual feed intake (RFI) on Nellore cattle. The main objectives of this study were to: 1) identify copy number variation (CNVs) in Nellore cattle from three selection lines; 2) identify and characterize CNV regions (CNVR) on these three lines; and 3) perform functional enrichment analyses of the CNVR identified.Results: A total of 14,914 unique CNVs and 1,884 CNVRs were identified when considering all lines as a single population. The CNVRs were non-uniformly distributed across the chromosomes of the three selection lines included in the study. The NeT line had the highest number of CNVRs (n = 1,493), followed by the NeS (n = 823) and NeC (n = 482) lines. The CNVRs covered 23,449,890 bp (0.94%), 40,175,556 bp (1.61%), and 63,212,273 bp (2.54%) of the genome of the NeC, NeS, and NeT lines, respectively. Two CNVRs were commonly identified between the three lines, and six, two, and four exclusive regions were identified for NeC, NeS, and NeT, respectively. All the exclusive regions overlap with important genes, such as SMARCD3, SLC15A1, and MAPK1. Key biological processes associated with the candidate genes were identified, including pathways related to growth and metabolism.Conclusion: This study revealed large variability in CNVs and CNVRs across three Nellore lines differentially selected for YW and RFI. Gene annotation and gene ontology analyses of the exclusive CNVRs to each line revealed specific genes and biological processes involved in the expression of growth and feed efficiency traits. These findings contribute to the understanding of the genetic mechanisms underlying the phenotypic differences among the three Nellore selection lines.
Predictive value of a stemness-based classifier for prognosis and immunotherapy response of hepatocellular carcinoma based on bioinformatics and machine-learning strategies
Authors: Chen Erbao , Zou Zhilin , Wang Rongyue , Liu Jie , Peng Zhen , Gan Zhe , Lin Zewei , Liu Jikui 
Published: April 2024

ObjectiveSignificant advancements have been made in hepatocellular carcinoma (HCC) therapeutics, such as immunotherapy for treating patients with HCC. However, there is a lack of reliable biomarkers for predicting the response of patients to therapy, which continues to be challenging. Cancer stem cells (CSCs) are involved in the oncogenesis, drug resistance, and invasion, as well as metastasis of HCC cells. Therefore, in this study, we aimed to create an mRNA expression-based stemness index (mRNAsi) model to predict the response of patients with HCC to immunotherapy.MethodsWe retrieved gene expression and clinical data of patients with HCC from the GSE14520 dataset and the Cancer Genome Atlas (TCGA) database. Next, we used the “one-class logistic regression (OCLR)” algorithm to obtain the mRNAsi of patients with HCC. We performed “unsupervised consensus clustering” to classify patients with HCC based on the mRNAsi scores and stemness subtypes. The relationships between the mRNAsi model, clinicopathological features, and genetic profiles of patients were compared using various bioinformatic methods. We screened for differentially expressed genes to establish a stemness-based classifier for predicting the patient’s prognosis. Next, we determined the effect of risk scores on the tumor immune microenvironment (TIME) and the response of patients to immune checkpoint blockade (ICB). Finally, we used qRT-PCR to investigate gene expression in patients with HCC.ResultsWe screened CSC-related genes using various bioinformatics tools in patients from the TCGA-LIHC cohort. We constructed a stemness classifier based on a nine-gene (PPARGC1A, FTCD, CFHR3, MAGEA6, CXCL8, CABYR, EPO, HMMR, and UCK2) signature for predicting the patient’s prognosis and response to ICBs. Further, the model was validated in an independent GSE14520 dataset and performed well. Our model could predict the status of TIME, immunogenomic expressions, congenic pathway, and response to chemotherapy drugs. Furthermore, a significant increase in the proportion of infiltrating macrophages, Treg cells, and immune checkpoints was observed in patients in the high-risk group. In addition, tumor cells in patients with high mRNAsi scores could escape immune surveillance. Finally, we observed that the constructed model had a good expression in the clinical samples. The HCC tumor size and UCK2 genes expression were significantly alleviated and decreased, respectively, by treatments of anti-PD1 antibody. We also found knockdown UCK2 changed expressions of immune genes in HCC cell lines.ConclusionThe novel stemness-related model could predict the prognosis of patients and aid in creating personalized immuno- and targeted therapy for patients in HCC.
Zinc metabolism and its role in immunity status in subjects with trisomy 21: chromosomal dosage effect
Authors: Ramacieri Giuseppe , Locatelli Chiara , Semprini Michela , Pelleri Maria Chiara , Caracausi Maria , Piovesan Allison , Cicilloni Michela , Vigna Marco , Vitale Lorenza , Sperti Giacomo , Corvaglia Luigi Tommaso , Pirazzoli Gian Luca , Strippoli Pierluigi , Catapano Francesca , Vione Beatrice , Antonaros Francesca 
Published: April 2024

IntroductionTrisomy 21 (T21), which causes Down syndrome (DS), is the most common chromosomal aneuploidy in humankind and includes different clinical comorbidities, among which the alteration of the immune system has a heavy impact on patient’s lives. A molecule with an important role in immune response is zinc and it is known that its concentration is significantly lower in children with T21. Different hypotheses were made about this metabolic alteration and one of the reasons might be the overexpression of superoxide dismutase 1 (SOD1) gene, as zinc is part of the SOD1 active enzymatic center.MethodsThe aim of our work is to explore if there is a linear correlation between zinc level and immune cell levels measured in a total of 217 blood samples from subjects with T21. Furthermore, transcriptome map analyses were performed using Transcriptome Mapper (TRAM) software to investigate whether a difference in gene expression is detectable between subjects with T21 and euploid control group in tissues and cells involved in the immune response such as lymphoblastoid cells, thymus and white blood cells.ResultsOur results have confirmed the literature data stating that the blood zinc level in subjects with T21 is lower compared to the general population; in addition, we report that the T21/control zinc concentration ratio is 2:3, consistent with a chromosomal dosage effect due to the presence of three copies of chromosome 21. The transcriptome map analyses showed an alteration of some gene’s expression which might explain low levels of zinc in the blood.DiscussionOur data suggest that zinc level is not associated with the levels of immunity cells or proteins analyzed themselves and rather the main role of this ion might be played in altering immune cell function.