bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cosmic variance suppression in radiation-hydrodynamic modelling of the reionization-era 21-cm signal
Authors: Acharya Anshuman , Garaldi Enrico , Ciardi Benedetta , Ma Qing-bo 
Published: March 2024

ABSTRACT
The 21-cm line emitted by neutral hydrogen is the most promising probe of the Epoch of Reionization (EoR). Multiple radio interferometric instruments are on the cusp of detecting its power spectrum. It is therefore essential to deliver robust theoretical predictions, enabling sound inference of the coeval Universe properties. The nature of this signal traditionally required the modelling of $\mathcal {O}(10^{7-8} \, {\rm Mpc}^3)$ volumes to suppress the impact of cosmic variance. However, the recently proposed Fixed & Paired (F&P) approach uses carefully crafted simulation pairs to achieve equal results in smaller volumes. In this work, we thoroughly test the applicability of and improvement granted by this technique to different observables of the 21-cm signal from the EoR. We employ radiation-magneto-hydrodynamics simulations to ensure the most realistic physical description of this epoch, greatly improving over previous studies using a seminumerical approach without accurate galaxy formation physics and radiative transfer. We estimate the statistical improvement granted by the F&P technique on predictions of the skewness, power spectrum, bispectrum, and ionized regions size distribution of the 21-cm signal at redshift 7 ≤ z ≤ 10 (corresponding to ${\ge}80{{\ \rm per\ cent}}$ of the gas being neutral). We find that the effective volume of F&P simulations is at least 3.5 times larger than traditional simulations. This directly translates into an equal improvement in the computational cost (in terms of time and memory). Finally, we confirm that a combination of different observables like skewness, power spectrum, and bispectrum across different redshifts can be utilized to maximize the improvement.
Deciphering recursive polyploidization in Lamiales and reconstructing their chromosome evolutionary trajectories
Authors: Wang Jiangli , Song Bowen , Yang Minran , Hu Fubo , Qi Huilong , Zhang Huizhe , Jia Yuelong , Li Yingjie , Wang Zhenyi , Wang Xiyin 
Published: March 2024

Abstract
Lamiales is an order of core eudicots with abundant diversity, and many Lamiales plants have important medicinal and ornamental values. Here, we comparatively reanalyzed 11 Lamiales species with well-assembled genome sequences and found evidence that Lamiales plants, in addition to a hexaploidization or whole-genome triplication (WGT) shared by core eudicots, experienced further polyploidization events, establishing new groups in the order. Notably, we identified a whole-genome duplication (WGD) occurred just before the split of Scrophulariaceae from the other Lamiales families, such as Acanthaceae, Bignoniaceae, and Lamiaceae, suggesting its likely being the causal reason for the establishment and fast divergence of these families. We also found that a WGT occurred ∼68 to 78 million years ago (Mya), near the split of Oleaceae from the other Lamiales families, implying that it may have caused their fast divergence and the establishment of the Oleaceae family. Then, by exploring and distinguishing intra- and intergenomic chromosomal homology due to recursive polyploidization and speciation, respectively, we inferred that the Lamiales ancestral cell karyotype had 11 proto-chromosomes. We reconstructed the evolutionary trajectories from these proto-chromosomes to form the extant chromosomes in each Lamiales plant under study. We must note that most of the inferred 11 proto-chromosomes, duplicated during a WGD thereafter, have been well preserved in jacaranda (Jacaranda mimosifolia) genome, showing the credibility of the present inference implementing a telomere-centric chromosome repatterning model. These efforts are important to understand genome repatterning after recursive polyploidization, especially shedding light on the origin of new plant groups and angiosperm cell karyotype evolution.
DNA methylation clocks for estimating biological age in Chinese cohorts
Authors: Zheng Zikai , Li Jiaming , Liu Tianzi , Fan Yanling , Zhai Qiao-Cheng , Xiong Muzhao , Wang Qiao-Ran , Sun Xiaoyan , Zheng Qi-Wen , Che Shanshan , Jiang Beier , Zheng Quan , Wang Cui , Liu Lixiao , Ping Jiale , Wang Si , Gao Dan-Dan , Ye Jinlin , Yang Kuan , Zuo Yuesheng , Ma Shuai , Yang Yun-Gui , Qu Jing , Zhang Feng , Jia Peilin , Liu Guang-Hui , Zhang Weiqi 
Published: March 2024

Abstract
Epigenetic clocks are accurate predictors of human chronological age based on the analysis of DNA methylation (DNAm) at specific CpG sites. However, a systematic comparison between DNA methylation data and other omics datasets has not yet been performed. Moreover, available DNAm age predictors are based on datasets with limited ethnic representation. To address these knowledge gaps, we generated and analyzed DNA methylation datasets from two independent Chinese cohorts, revealing age-related DNAm changes. Additionally, a DNA methylation aging clock (iCAS-DNAmAge) and a group of DNAm-based multi-modal clocks for Chinese individuals were developed, with most of them demonstrating strong predictive capabilities for chronological age. The clocks were further employed to predict factors influencing aging rates. The DNAm aging clock, derived from multi-modal aging features (compositeAge-DNAmAge), exhibited a close association with multi-omics changes, lifestyles, and disease status, underscoring its robust potential for precise biological age assessment. Our findings offer novel insights into the regulatory mechanism of age-related DNAm changes and extend the application of the DNAm clock for measuring biological age and aging pace, providing the basis for evaluating aging intervention strategies.
Flare prediction after tapering the dose of tumour necrosis factor inhibitors in patients with axial spondyloarthritis: a nationwide cohort study
Authors: Yeo Jina , Kim Ju Yeon , Park Jin Kyun , Shin Kichul , Lee Eun Young , Kim Tae-Hwan , Park Jun Won 
Published: March 2024

Abstract

Objectives
To develop a model for predicting flares after tapering the dose of tumour necrosis factor inhibitors (TNFi) in patients with axial spondyloarthritis (axSpA).

Methods
Data were obtained from the Korean College of Rheumatology Biologics and Targeted Therapy Registry. In total, 526 patients who received the standard-dose TNFi for at least 1 year and tapered their dose were included in the derivation cohort. The main outcome was a flare occurrence defined as an Ankylosing Spondylitis Disease Activity Score with C-reactive protein (ASDAS-CRP) score of ≥2.1 after 1 year of TNFi tapering. The final prediction model was validated using an independent cohort.

Results
Among 526 patients, 127 (24.1%) experienced flares. The final prediction model included negative human leucocyte antigen B27 (β = 1.088), inflammatory back pain (β = 1.072), psoriasis (β = 1.567), family history of SpA (β = 0.623), diabetes mellitus (β = 1.092), TNFi tapering by ≥50% of the standard-dose (β = 0.435), ASDAS-CRP at tapering (β = 1.029), and Bath Ankylosing Spondylitis Functional Index score at tapering (β = 0.194) as covariates. It showed an excellent discrimination performance (AUC = 0.828). According to the predictive risk, patients were classified into three groups (low-, intermediate- and high-risk). The probabilities of flares in these groups were 4.5%, 18.1% and 61.8%, respectively. The performance of the model in the validation cohort was also comparable.

Conclusion
The established prediction model accurately predicted the risk of flares after TNFi dose tapering in patients with axSpA using eight simple clinical parameters, which could be helpful to select appropriate patients for tapering their TNFi without flare in daily clinical practice.
Hydroxychloroquine in lupus or rheumatoid arthritis pregnancy and risk of major congenital malformations: a population-based cohort study
Authors: Nguyen Ngoc V , Svenungsson Elisabet , Dominicus Annica , Altman Maria , Hellgren Karin , Simard Julia F , Arkema Elizabeth V 
Published: March 2024

Abstract

Objectives
To assess the infant risk of major congenital malformations (MCM) associated with first-trimester exposure to hydroxychloroquine (HCQ) among mothers with systemic lupus erythematosus (SLE) or rheumatoid arthritis (RA).

Methods
This population-based cohort study utilized Swedish nationwide registers and included all singleton births (2006–2021) among individuals with prevalent SLE or RA in Sweden. The exposure was filling ≥1 HCQ prescription during the first trimester. The outcome was infant MCM within 1 year of birth. Inverse probability of treatment weighting was applied to adjust for potential confounders (e.g. maternal smoking, body mass index, pregestational diabetes and corticosteroids). Modified Poisson regression models with robust variance were used to estimate risk ratios (RR) and 95% CI.

Results
We included 1007 births (453 exposed) and 2500 births (144 exposed) in the SLE and RA cohorts, respectively. The MCM risks in the SLE overall cohort, exposed and unexposed groups were 3.6%, 3.7% and 3.4%, respectively. The corresponding figures in the RA cohort were 4.4%, 5.6% and 4.3%, respectively. The adjusted RRs (95% CI) were 1.29 (0.65, 2.56) in the SLE cohort, 1.32 (0.56, 3.13) in the RA cohort and 1.30 (0.76, 2.23) in the pooled analysis. The adjusted risk difference (exposed vs unexposed) was small (0.9% in SLE and 1.3% in RA). Sensitivity analyses examining different exposure and outcome windows yielded similar findings.

Conclusion
First-trimester exposure to HCQ was not associated with a significantly increased risk of MCM. HCQ’s benefits may outweigh the risks in managing SLE or RA during pregnancy.
Can complement activation be the missing link in antiphospholipid syndrome?
Authors: Venturelli Veronica , Maranini Beatrice , Tohidi-Esfahani Ibrahim , Isenberg David A , Cohen Hannah , Efthymiou Maria 
Published: March 2024

Abstract
APS is an autoimmune disorder with life-threatening complications that, despite therapeutic advantages, remains associated with thrombotic recurrences and treatment failure. The role of complement activation in APS pathogenesis is increasingly recognized, specifically in obstetric APS. However, its exact role in thrombotic APS and on the severity of the disease is not yet fully elucidated. Further mechanistic studies are needed to delineate the role of complement activation in the various APS clinical manifestations with aim to identify novel markers of disease severity, together with clinical trials to evaluate the efficacy of complement inhibition in APS. This could ultimately improve risk stratification in APS, patient-tailored targeted therapy with complement inhibition identified as an adjunctive treatment. This article reviews current findings and challenges about complement activation in APS, discusses the potential role of platelet-mediated complement activation in this setting and provides an overview of clinical implications and current therapeutics.
The electric vehicle routing problem of a new mobile charging service
Authors: Ren Kanghui , Li Maosheng , Cen Xuekai , Huang Helai 
Published: March 2024

Abstract
A novel mobile charging service that utilizes vehicle-to-vehicle (V2V) charging technology has recently been proposed as a supplement to fixed charging infrastructure (CI), enabling electric vehicles (EVs) to exchange electricity. This study formulates a vehicle routing problem (VRP) of vehicle-to-vehicle (V2V) charging, optimizing the routing of DVs to service RVs while taking into account their willingness to join the V2V charging platform. A mixed integer linear programming (MILP) model is established to optimize the VRP-V2V (i.e. the VRP of V2V charging), which is known to be NP-hard. To solve large-scale instances for real-world applications, we propose an adaptive large neighborhood search (ALNS) algorithm, which, when combined with the structure of the VRP-V2V problem, utilizes four local search procedures to enhance solution quality following destroy and repair operators. Results indicate that the proposed ALNS algorithm outperforms the optimization solver CPLEX in small-scale instances, and can solve large-scale instances that are infeasible using CPLEX solver. In a numerical analysis of Changsha's large-scale network, we demonstrate that the V2V platform can save an average of 33.1% on the charging cost of recharging vehicles, hence raising customer satisfaction with charging services and reducing range anxiety. The platform's profitability is also increased by using V2V charging in areas lacking fixed charging infrastructure.
Association Between Intrapartum Nitrous Oxide for Labor Analgesia and Short-Term Neonatal Outcomes
Authors: Starosta Anabel , Lundsberg Lisbet , Culhane Jennifer , Partridge Caitlin , Grechukhina Olga , Son Moeun 
Published: March 2024

OBJECTIVE:
To evaluate the association between intrapartum nitrous oxide use and adverse short-term neonatal outcomes.

METHODS:
This was a retrospective cohort study of individuals with singleton gestations at 35 or more weeks who attempted labor and delivered at an academic hospital between June 1, 2015, and February 28, 2020. Data were extracted from the electronic medical record using billing and diagnostic codes. Patients were classified based on whether they received no intrapartum analgesia or received nitrous oxide only. Those who received other analgesia types were excluded. The primary outcome was neonatal intensive care unit (NICU) admission. Secondary outcomes included Apgar score less than 7 at 1 minute and 5 minutes, respiratory composite outcome (including meconium aspiration syndrome, neonatal bronchopulmonary disorders, neonatal transient tachypnea, and other neonatal respiratory distress that required NICU admission), hypoglycemia, and hyperbilirubinemia. Univariable and multivariable analyses were used to estimate the association between nitrous oxide exposure intrapartum and the selected outcomes.

RESULTS:
Of 6,047 included, 4,153 (68.7%) received no analgesia, and 1,894 (31.3%) received nitrous oxide only. In comparison with individuals who received no analgesia, those who received nitrous oxide were more likely to be nulliparous, be of Black racial identity, have noncommercial insurance, and be less likely to deliver by intrapartum cesarean. The reception of nitrous oxide, compared with the reception of no analgesia, was associated with a lower likelihood of NICU admission (6.4% vs 8.1%; adjusted odds ratio [aOR] 0.77, 95% CI, 0.62–0.96) and an increased likelihood of neonatal hyperbilirubinemia (aOR 1.23, 95% CI, 1.08–1.41). Inhaled nitrous oxide exposure, in comparison with the reception of no analgesia, was not associated with the other secondary outcomes, including Apgar score less than 7 at 1 minute (odds ratio [OR] 0.74, 95% CI, 0.50–1.10) or 5 minutes (OR 0.91, 95% CI, 0.32–2.60), respiratory composite outcome (OR 0.91, 95% CI, 0.70–1.17), and hypoglycemia (OR 0.82, 95% CI, 0.64–1.05).

CONCLUSION:
In this single-center retrospective cohort of low-risk patients, intrapartum inhaled nitrous oxide, compared with the reception of no analgesia, was associated with a decreased risk for NICU admission but with an increased risk for hyperbilirubinemia; other outcomes did not differ. These findings may be used to counsel patients when considering nitrous oxide for labor analgesia.
WALANT office based endoscopic cubital tunnel release
Authors: Hoelscher Victoria , Pientka William F. 
Published: March 2024

Background:
Cubital tunnel syndrome is a common condition caused by compression of the ulnar nerve around the medial elbow. Surgical treatment usually involves open in situ ulnar nerve decompression unless ulnar nerve instability is noted. Endoscopic techniques for cubital tunnel release have been developed and implemented with excellent patient and surgeon satisfaction. Endoscopic cubital tunnel release can be performed in an office based procedure room under wide awake local anesthesia no tourniquet principles. We present our setup and technique for performing an endoscopic cubital tunnel release procedure in an office based setting under local anesthesia.

Methods:
Local anesthesia is injected along the course of the ulnar nerve on the medial arm and forearm extending 10 cm proximal and distal to the medial epicondyle. After allowing approximately 30 min for appropriate vasoconstriction, the patient is placed in a supine position with the arm abducted and externally rotated position. The endoscopic cubital tunnel release is then performed.

Discussion:
Our described technique eliminates the need for placement of a prophylactic tourniquet and thereby the need for the procedure to be performed within an OR setting. It also utilizes a single-stage anesthetic administration, which facilitates ease of completion and performance in an office based setting. There is a significant cost savings when endoscopic cubital tunnel release is performed in an office-based procedure room compared to in the operating room.

Conclusions:
Office-based endoscopic cubital tunnel release can be safely performed utilizing WALANT techniques, leading to high patient satisfaction and decreased overall cost of care.

Level of Evidence:
Therapeutic IV
Great Toe Tip Reconstruction after Severe COVID-19 Using Hemi-pulp V-Y Advancement Flap: A Case Report
Authors: Hane Rika , Akita Shinsuke , Kubo Yohei , Takei Masahiro , Mitsukawa Nobuyuki 
Published: March 2024

Summary:
“COVID toe,” one of the extrapulmonary disorders of coronavirus disease 2019 (COVID-19), may result in toe necrosis. In this case, we successfully reconstructed a severe COVID-19-induced defect in the great toe by using an innervated hemi-pulp V-Y advancement flap. A 48-year-old woman was diagnosed with fulminant myocarditis due to COVID-19 and received intensive care. Even after the acute phase, a skin defect measuring 10 mm × 7 mm was noted, exposing the underlying bone on her right great toe tip. Because of ulceration, she was unable to start walking training. To continue rehabilitation, we reconstructed it with the innerved hemi-pulp V-Y advancement flap. The pain improved quickly, and rehabilitation was resumed. During the 6-month follow-up period, no cosmetic or functional complications were observed. Plantar pressure measurements demonstrated favorable loading on the great toe, and it was a favorable outcome in walking function. This flap is a valuable option as one of the innervated flaps for toe-end necrosis with preserved blood flow, which helps in implementing prompt gait rehabilitation.
Demographic Characteristics, Clinical Presentations, and Risk Factors Impacting Visual Outcomes in Peripheral Ulcerative Keratitis
Authors: Singh Rohan Bir , Atta Sarah , Srikumaran Divya , Jhanji Vishal 
Published: March 2024

Purpose:
To assess the demographic characteristics, ophthalmic and systemic presentations, and risk factors impacting the outcomes in patients diagnosed with peripheral ulcerative keratitis (PUK).

Methods:
This retrospective study includes patients diagnosed with PUK at a tertiary care center over 13 years. A descriptive analysis of the demographics, clinical history, and presentation was performed. A reverse risk analysis was performed to assess the PUK resolution in patients with underlying autoimmune and non-autoimmune etiologies. Finally, we evaluated the correlation between treatment duration and final best corrected visual acuity (BCVA) and continuous and categorical variables.

Results:
A total of 58 eyes of 51 patients with a mean age of 59.67 ± 13.41 years diagnosed with PUK were included in the study; 58.82% were female. The resolution duration was significantly shorter in patients with autoimmune etiologies (vs. non-autoimmune etiologies, P = 0.028) and female patients (vs. male patients, P = 0.008). The BCVA worsened in patients with non-autoimmune etiologies after treatment (P = 0.17). Despite worse BCVA at presentation in patients with underlying autoimmune etiologies, significantly better final vision outcomes were observed (P = 0.04). Linear regression analysis showed that longer treatment duration (P = 0.001; R2 = 0.1704) and worse vision (P = 0.002; R2 = 0.1502) at presentation were the primary risk factors of poor vision outcomes. Similarly, the treatment duration was significantly longer in male compared with female patients (P < 0.001; R2 = 0.2027).

Conclusions:
The clinical outcomes in PUK with underlying autoimmune disorders were observed to be better than non-autoimmune etiologies, which may be attributed to the early detection of the PUK-related changes and aggressive medical management. A delayed diagnosis of PUK leads to poor vision outcomes.
Squaring the Circle. Brain death and organ transplantation
Authors: Doyle Howard R. 
Published: March 2024

Purpose of review
The adoption of brain death played a crucial role in the development of organ transplantation, but the concept has become increasingly controversial. This essay will explore the current state of the controversy and its implications for the field.

Recent developments
The brain death debate, long limited to the bioethics community, has in recent years burst into the public consciousness following several high-profile cases. This has culminated in the reevaluation of the Uniform Determination of Death Act (UDDA), which is in the process of being updated. Any change to the UDDA has the potential to significantly impact the availability of organs.

Summary
The current update to the UDDA introduces an element of uncertainty, one the brain death debate had not previously had.
Thoraco-abdominal normothermic regional perfusion for thoracic transplantation in the United States: current state and future directions
Authors: Bommareddi Swaroop , Lima Brian , Shah Ashish S. , Trahanas John M. 
Published: March 2024

Purpose of reviewTo provide an update regarding the state of thoracoabdominal normothermic regional perfusion (taNRP) when used for thoracic organ recoveryRecent findingstaNRP is growing in its utilization for thoracic organ recovery from donation after circulatory death donors, partly because of its cost effectiveness. taNRP has been shown to yield cardiac allograft recipient outcomes similar to those of brain-dead donors. Regarding the use of taNRP to recover donor lungs, United Network for Organ Sharing (UNOS) analysis shows that taNRP recovered lungs are noninferior, and taNRP has been used to consistently recover excellent lungs at high volume centers. Despite its growth, ethical debate regarding taNRP continues, though clinical data now supports the notion that there is no meaningful brain perfusion after clamping the aortic arch vessels.SummarytaNRP is an excellent method for recovering both heart and lungs from donation after circulatory death donors and yields satisfactory recipient outcomes in a cost-effective manner. taNRP is now endorsed by the American Society of Transplant Surgeons, though ethical debate continues.