bluuebunny/crossref_metadata_2025_split huggingface dataset:
Benign Breast Diseases: Classification, Diagnosis, and Management
Authors: Guray Merih , Sahin Aysegul A. 
Published: May 2006

AbstractLearning ObjectivesAfter completing this course, the reader will be able to: Discuss the clinical and histopathologic features of benign conditions of the breast.Identify the risks of benign lesions in relation to developing subsequent breast cancer.Describe the clinicopathologic features of benign neoplasms.Access and take the CME test online and receive 1 AMA PRA category 1 credit at CME.TheOncologist.comBenign breast diseases constitute a heterogeneous group of lesions including developmental abnormalities, inflammatory lesions, epithelial and stromal proliferations, and neoplasms. In this review, common benign lesions are summarized and their relationship to the development of subsequent breast cancer is emphasized.
Therapeutic Vaccines for Prostate Cancer
Authors: Tarassoff Christopher P. , Arlen Philip M. , Gulley James L. 
Published: May 2006

AbstractLearning ObjectivesAfter completing this course, the reader will be able to: List the different types of vaccines being studied clinically in prostate cancer.Explain the basic concepts of generating an active immune response.Discuss the clinical trials with prostate cancer vaccines including immunologic and clinical responses.Access and take the CME test online and receive 1 AMA PRA category 1 credit at CME.TheOncologist.comProstate cancer is the most common, noncutaneous cancer for men in the U.S., leading to more than 30,000 deaths a year. Vaccines for prostate cancer, which for several years have been shown to generate immunologic responses, are beginning to show significant clinical promise. At present, numerous therapeutic options are being investigated, including autologous and allogeneic whole-tumor cell vaccines, dendritic cell vaccines, and poxvirus-based vaccines. Advances in basic immunology have translated into new, more complex therapeutic strategies. The findings from current trials and the demonstrated potential to combine vaccines with conventional therapies herald a promising future for the treatment of prostate cancer. This review highlights recent advances and clinical trials in immunotherapy for prostate cancer, along with current thoughts on immunologic and clinical monitoring of these trials.
Primary Mediastinal Large B-Cell Lymphoma
Authors: Savage Kerry J. 
Published: May 2006

AbstractLearning ObjectivesAfter completing this course, the reader will be able to: List the key clinical features of PMBCL.Discuss the literature on chemotherapy in PMBCL and the role of radiotherapy in PMBCL.Describe the pathologic features of PMBCL.Access and take the CME test online and receive 1 AMA PRA category 1 credit at CME.TheOncologist.comPrimary mediastinal large B-cell lymphoma represents a distinct entity with unique clinicopathologic features and a molecular gene-expression signature reminiscent of nodular sclerosis subtype of classical Hodgkin's lymphoma. Recent studies, including those using a refined molecular signature, suggest that the outcome is more favorable than that of diffuse large B-cell lymphoma. Using historical comparisons, dose-dense and dose-intensive regimens may be more effective than cyclophosphamide, doxorubicin, vincristine, and prednisone chemotherapy; however, the impact of adding rituximab to these regimens and effect on outcome comparisons is unknown. Clinical trials exploring these questions in addition to the benefit of consolidative radiotherapy are necessary to definitively answer these questions.
Intravascular Lymphoma: The Oncologist's “Great Imitator”
Authors: Zuckerman Dan , Seliem Rania , Hochberg Ephraim 
Published: May 2006

Abstract

Learning Objectives
After completing this course, the reader will be able to: Describe the clinicopathologic features of IVL that distinguish it from the other large-cell lymphomas.Discuss the diagnostic tests helpful in evaluating a case of suspected IVL.Explain the rationale for treatment approaches in patients with IVL, including the role of hematopoietic stem cell transplantation.
Access and take the CME test online and receive 1 AMA PRA category 1 credit at CME.TheOncologist.com
Intravascular lymphoma (IVL) is a rare subtype of extranodal diffuse large B-cell lymphoma with a distinct presentation. Anatomically the disease is characterized by the proliferation of clonal lymphocytes within small vessels with relative sparing of the surrounding tissue. The clinical symptoms of the disease are dependent on the specific organ involvement, which most often includes the central nervous system and skin. Because of the various modes of presentation and the rarity of IVL, the diagnosis is often made postmortem. The diagnosis is almost exclusively made by surgical biopsy of a suspected site of involvement. Advances in imaging and immunohistochemistry have led to increasing antemortem diagnosis of this lymphoma. Although some patients with this disease may be curable with aggressive therapy, further research into novel treatment strategies is needed to improve outcome. Some potential insights into future therapies may be drawn from the small amount of basic science literature relevant to this entity. This review provides a concise, up-to-date summary of IVL.
Ewing's Sarcoma Family of Tumors: Current Management
Authors: Bernstein Mark , Kovar Heinrich , Paulussen Michael , Randall R. Lor , Schuck Andreas , Teot Lisa A. , Juergensg Herbert 
Published: May 2006

Abstract

Learning Objectives
After completing this course, the reader will be able to: Describe the presentation, differential diagnosis, and prognosis for patients with Ewing's sarcoma.Explain the principles of multidisciplinary management of Ewing's sarcoma.Discuss the late effects of the therapy for Ewing's sarcoma.
Access and take the CME test online and receive 1 AMA PRA category 1 credit at CME.TheOncologist.com
Ewing's sarcoma is the second most frequent primary bone cancer, with approximately 225 new cases diagnosed each year in patients less than 20 years of age in North America. It is one of the pediatric small round blue cell tumors, characterized by strong membrane expression of CD99 in a chain-mail pattern and negativity for lymphoid (CD45), rhabdomyosarcoma (myogenin, desmin, actin) and neuroblastoma (neurofilament protein) markers. Pathognomonic translocations involving the ews gene on chromosome 22 and an ets-type gene, most commonly the fli1 gene on chromosome 11, are implicated in the great majority of cases. Clinical presentation is usually dominated by local bone pain and a mass. Imaging reveals a technetium pyrophosphate avid lesion that, on plain radiograph, is destructive, diaphyseal and classically causes layered periosteal calcification. Magnetic resonance best defines the extent of the lesion. Biopsy should be undertaken by an experienced orthopedic oncologist. Approximately three quarters of patients have initially localized disease. About two thirds survive disease-free. Management, preferably at a specialist center with a multi-disciplinary team, includes both local control—either surgery, radiation or a combination—and systemic chemotherapy. Chemotherapy includes cyclic combinations, incorporating vincristine, doxorubicin, cyclophosphamide, etoposide, ifosfamide and occasionally actinomycin D. Topotecan in combination with cyclophosphamide has shown preliminary activity. Patients with initially metastatic disease fare less well, with about one quarter surviving. Studies incorporating intensive therapy followed by stem cell infusion show no clear benefit. New approaches include anti-angiogenic therapy, particularly since vascular endothelial growth factor is an apparent downstream target of the ews-fli1 oncogene.
Techniques for Mammalian Cell Tissue Culture
Authors: Phelan Mary C. 
Published: May 2006

AbstractThis appendix opens with detailed discussions on the latest principles of sterile technique and preparation of culture media. Step‐by‐step protocols describe trypsinizing and subculturing monolayer cultures, passaging suspension cultures, freezing and thawing cells, counting cells using a hemacytometer, and preparing cells for transport.
Hygrothermische Beanspruchung und Lebensdauer von Wärmedämm‐Verbundsystemen
Authors: Künzel Hartwig M. , Künzel Helmut , Sedlbauer Klaus 
Published: May 2006

AbstractDas Alterungsverhalten und die Lebensdauer von Fassadensystemen wird stark von der hygrothermischen Beanspruchung beeinflußt. Neben den Witterungsbedingungen Temperatur, Strahlung und Luftfeuchte wirken häufig auch noch äußere oder innere Feuchtequellen, z. B. Schlagregen, Baufeuchte oder Oberflächenbetauung auf Außenwände ein. Wegen ihrer geringen Masse sind Wärmedämm‐Verbundsysteme (WDVS) davon z. T. besonders betroffen. Dennoch zeigt die Langzeitstudie an Objekten mit WDVS, daß damit keine erhöhte Schadensanfälligkeit verbunden ist. Abgesehen von einigen optischen Mängeln ist das Langzeitverhalten von WDVS als sehr positiv zu bewerten. Bei regelmäßiger Wartung entspricht die Lebensdauer von WDVS der von herkömmlich verputzten Außenwänden. (© 2006 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
The Influence of Sawmill Wood Wastes on the Distribution and Population of Macroinvertebrates at Benin River, Niger Delta Area, Nigeria
Authors: Arimoro Francis O. , Osakwe Emeka I. 
Published: May 2006

AbstractThe impact of sawmill wood wastes on the distribution of benthic macroinvertebrates at the Sapele section of Benin River, Niger Delta, Nigeria, was investigated from March 2005 to August 2005. A total of 434 individuals were collected by kick‐sampling method, representing 21 taxa of benthic macroinvertebrates. Three stations, 1, 2, and 3, were selected from upstream of the site, receiving wood wastes discharge, the impacted site and its down stream, respectively. Among the water quality variables, conductivity, dissolved oxygen, biochemical oxigen demand (BOD5), nitrate‐nitrogen, phosphate‐phosphorus, transparency, and alkalinity were significantly different (P<0.05) among the stations. Orthogonal comparison by Duncan's multiple range test showed that station 2 (the impacted site) was the cause of the difference. More sensitive species such as Ephemeroptera or Plecoptera were completely absent from station 2, the impacted site. Species abundance was similar in station 1 and 3, indicating that the wood wastes must have adversely affected the distribution of these macroinvertebrates, especially the intolerant species. The wood waste discharge not only altered the water chemistry, but also stimulated the abundance of less‐sensitive macroinvertebrate species.
Ab Initio Molecular Dynamics Studies of Ionic Dissolution and Precipitation of Sodium Chloride and Silver Chloride in Water Clusters, NaCl(H2O)n and AgCl(H2O)n, n = 6, 10, and 14
Authors: Siu Chi‐Kit , Fox‐Beyer Brigitte S. , Beyer Martin K. , Bondybey Vladimir E. 
Published: May 2006

AbstractAn ab initio molecular dynamics method was used to compare the ionic dissolution of soluble sodium chloride (NaCl) in water clusters with the highly insoluble silver chloride (AgCl). The investigations focused on the solvation structures, dynamics, and energetics of the contact ion pair (CIP) and of the solvent‐separated ion pair (SSIP) in NaCl(H2O)n and AgCl(H2O)n with cluster sizes of n = 6, 10 and 14. We found that the minimum cluster size required to stabilize the SSIP configuration in NaCl(H2O)n is temperature‐dependent. For n = 6, both configurations are present as two distinct local minima on the free‐energy profile at 100 K, whereas SSIP is unstable at 300 K. Both configurations, separated by a low barrier (<10 kJ mol−1), are identifiable on the free energy profiles of NaCl(H2O)n for n = 10 and 14 at 300 K, with the Na+/Cl− pairs being internally solvated in the water cluster and the SSIP configuration being slightly higher in energy (<5 kJ mol−1). In agreement with the low bulk solubility of AgCl, no SSIP minimum is observed on the free‐energy profiles of finite AgCl(H2O)n clusters. The AgCl interaction is more covalent in nature, and is less affected by the water solvent. Unlike NaCl, AgCl is mainly solvated on the surface in finite water clusters, and ionic dissolution requires a significant reorganization of the solvent structure.
Low‐Temperature Phases of Rubidium Silver Iodide: Crystal Structures and Dynamics of the Mobile Silver Ions.
Authors: Funke Klaus , Banhatti Radha D. , Wilmer Dirk , Dinnebier Robert , Fitch Andrew , Jansen Martin 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
New Type of Near‐Infrared to Visible Photon Upconversion in Tm2+‐Doped CsCaI3.
Authors: Beurer Eva , Grimm Judith , Gerner Pascal , Guedel Hans U. 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis, Characterization, and Photocatalytic Properties of InVO4 Nanoparticles.
Authors: Zhang Liwu , Fu Hongbo , Zhang Chuan , Zhu Yongfa 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Direct Asymmetric anti‐Mannich‐Type Reactions Catalyzed by a Designed Amino Acid.
Authors: Mitsumori Susumu , Zhang Haile , Cheong Paul Ha‐Yeon , Houk K. N. , Tanaka Fujie , Barbas Carlos F. III 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
C—H Activation as a Strategic Reaction: Enantioselective Synthesis of 4‐Substituted Indoles.
Authors: Davies Huw M. L. , Manning James R. 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Highly Diastereo‐ and Enantioselective Direct Aldol Reactions in Water.
Authors: Hayashi Yujiro , Sumiya Tatsunobu , Takahashi Junichi , Gotoh Hiroaki , Urushima Tatsuya , Shoji Mitsuru 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Preparation of New, Optically Active 1,2‐Ferrocenyldiamine Ligands and Their Application to Ruthenium‐Catalyzed Asymmetric Transfer Hydrogenation of Ketones.
Authors: Fukuzawa Shin‐ichi , Suzuki Takashi 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Highly Selective Preparation of Allenic and Homopropargylic Hydrazides Through Regiospecific Addition of Propargyltrichlorosilane and Allenyltrichlorosilane to Various Types of N‐Acylhydrazones.
Authors: Schneider Uwe , Sugiura Masaharu , Kobayashi Shu 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Palladium(0)‐Catalyzed Alkylative Cyclization of Alkynals and Alkynones: Remarkable trans‐Addition of Organoboronic Reagents.
Authors: Tsukamoto Hirokazu , Ueno Tatsuhiko , Kondo Yoshinori 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
2‐(3‐Arylhydrazono‐3‐formyl‐2‐oxopropyl)‐1H‐isoindole‐1,3(2H)‐dione in Heterocyclic Synthesis. Novel Derivatives of Pyridazin‐6(1H)‐one, Pyridazin‐6(1H)‐imine, and Pyrazolo[5,1‐c][1,2,4]triazine Incorporating an N‐(2‐Oxoethyl)phthalimide Moiety.
Authors: Al‐Omran Fatima , El‐Khair Adel A. 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Novel Synthesis of Optically Active 2‐Ethylhexanoic Acid, 2‐Ethylhexanol, and 2‐Ethylhexylamine via the Asymmetric Favorskii Rearrangement.
Authors: Miura Motofumi , Toriyama Masaharu , Motohashi Shigeyasu 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Trimethylammonium Fluorochromate (TriMAFC): A Convenient New and Mild Reagent for Oxidation of Organic Substrates.
Authors: Sadjadi S. A. Seyed , Ghammamy S. 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
An Efficient and General Method for the Deoxygenation of Organic N‐Oxides Using Zn(OTf)2 and Cu(OTf)2.
Authors: Saini Anil , Kumar Sanjay , Sandhu Jagir S. 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Construction of Quaternary Stereocenters by Efficient and Practical Conjugate Additions to α,β‐Unsaturated Ketones with a Chiral Organic Catalyst.
Authors: Wu Fanghui , Li Hongming , Hong Ran , Deng Li 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Rhodium‐Catalyzed Deallylation of Allylmalonates and Related Compounds.
Authors: Tursky Matyas , Necas David , Drabina Pavel , Sedlak Milos , Kotora Martin 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Iron‐Catalyzed Cross‐Coupling Between Alkenyl and Dienyl Sulfonates and Functionalized Arylcopper Reagents.
Authors: Dunet Guillaume , Knochel Paul 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Highly Enantioselective Pd‐Catalyzed Allylic Alkylation Using New Chiral Ferrocenylphosphinoimidazolidine Ligands.
Authors: Jin Myung‐Jong , Takale Vijay B. , Sarkar M. S. , Kim Young‐Mok 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Economical and Convenient Carbonyl Transposition Approach Toward a 2‐Arylcycloheptanone Derivative.
Authors: Bracca Andrea B. J. , Kaufman Teodoro S. 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Convenient Preparation of Heteroaryl Sulfonamides and Sulfonyl Fluorides from Heteroaryl Thiols.
Authors: Wright Stephen W. , Hallstrom Kelly N. 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Facile Synthetic Route to Highly Functionalized 2,4‐Pyrrolidinediones: A New Base‐Catalyzed Cyclization.
Authors: Jin Yu‐Zi , Yin Bing Zhu , Lee Youn‐Sik 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Interaction of 2‐Aminoindoles with Tetracyanoethylene. Part 2. 3‐Dicyanomethylene‐2‐iminoindolines.
Authors: Sadovoy A. V. , Golubeva G. A. 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A New Approach to Difficult Fischer Synthesis: The Use of Zinc Chloride Catalyst in Triethylene Glycol under Controlled Microwave Irradiation.
Authors: Lipinska Teodozja M. , Czarnocki Stefan J. 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Michael Addition of Indole to α,β‐Unsaturated Ketones Catalyzed by Silica Sulfuric Acid under Ultrasonic Irradiation.
Authors: Li Ji‐Tai , Dai Hong‐Guang , Xu Wen‐Zhi , Li Tong‐Shuang 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of 2‐[5‐Amino‐2,3‐dihydro‐4H‐imidazol‐4‐ylidene]malononitriles
Authors: Eremkin A. V. , Ershov O. V. , Kayukov Ya. S. , Sheverdov V. P. , Nasakin O. E. , Tafeenko V. A. , Nurieva E. V. 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Sc(OTf)3‐Catalyzed [3 + 2]‐Cycloaddition of Aziridines with Nitriles under Solvent‐Free Conditions.
Authors: Wu Jie , Sun Xiaoyu , Xia Hong‐Guang 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
One‐Pot Cross‐Metathesis/Tandem Carbonyl Ylide Formation — Intramolecular Cycloaddition of an Unsaturated 2‐Diazo‐3,6‐diketoester.
Authors: Hodgson David M. , Angrish Deepshikha , Labande Agnes H. 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Microwave‐Assisted Synthesis and Transformations of Sterically Hindered 3‐(5‐Tetrazolyl)pyridines.
Authors: Lukyanov Sergey M. , Bliznets Igor V. , Shorshnev Sergey V. , Aleksandrov Grigory G. , Stepanov Aleksandr E. , Vasil'ev Andrei A. 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Rapid Generation of Molecular Complexity Using “Hybrid” Multi‐Component Reactions (MCRs): Application to the Synthesis of α‐Amino Nitriles and 1,2‐Diamines.
Authors: Shiers Jason J. , Clarkson Guy J. , Shipman Michael , Hayes Jerome F. 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Diastereodirected Synthesis of 1‐Aryl‐4‐phenyl‐β‐carbolines
Authors: Semenov B. B. , Novikov K. A. , Smushkevich Yu. I. , Azev V. N. , Kachala V. V. 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.