bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prediction for swelling characteristics of compacted bentonite
Authors: Komine Hideo , Ogata Nobuhide 
Published: March 2008

Compacted bentonites are attracting greater attention as back-filling (buffer) materials for high-level nuclear waste repositories. For this purpose, it is very important to quantitatively evaluate the swelling characteristics of compacted bentonite. New equations for evaluating the relationship between the swelling deformation of compacted bentonite and the distance between two montmorillonite layers are derived. New equations for evaluating the ion concentration of pore water and the specific surface of bentonite, which significantly influence the swelling characteristics of compacted bentonite, are proposed. Furthermore, a prediction method for the swelling characteristics of compacted bentonite is presented by combining the new equations with the well-known theorectical equations of repulsive and attractive forces between two montmorillonite layers. The applicability of this method was investigated by comparing the predicted results with laboratory test results on the swelling deformation and swelling pressure of compacted bentonites. Key words: bentonite, diffuse double-layer theory, van der Waals force, nuclear wastes disposal, swelling deformation, swelling pressure.
Use of the piezocone test to predict the axial capacity of driven and jacked piles in clay
Authors: Almeida Marcio SS , Danziger Fernando AB , Lunne Tom 
Published: March 2008

Results of 43 load tests on driven and jacked piles performed at eight calyey sites have been back-analysed using piezocone test data. A method to evaluate the axial capacity of piles has been proposed in which the pile unit skin friction and the unit end bearing resistance are computed from the net corrected cone resistance, qnet. Correlation factors between piezocone and pile load tests were back-calculated using this approach. As most of the pile tests performed were tension tests, special emphasis was given to the evaluation of the pile unit skin friction. Key words: clay, pile, piezocone, cone penetration test, axial pile capacity, skin friction.
On the prediction of hydraulic conductivity of frozen soils
Authors: Tarnawski Vlodek R , Wagner Bernhard 
Published: March 2008

This paper describes a mathematical model for predicting the hydraulic conductivity of partially frozen soils on the basis of limited input data such as grain size distribution and bulk density or porosity. A new model is based on an analogy for the hydraulic conductivity of frozen and unfrozen soils and models for the estimation of hydraulic properties of soils and unfrozen water content. Campbell's model was used for prediction of soil-water characteristics from limited data, while unfrozen water content was obtained from two models (by P.J. Williams and D.M. Anderson) applied to two different temperature ranges. The new model can be used for the rapid estimation of the hydraulic conductivity of practically any freezing soil having log-normal grain size distribution and for computer simulation of moisture migration in soils below the freezing point. An acceptable conformity between the model prediction and measured data for pure sand has been achieved. The computer program developed requires the following input data: grain size distribution, bulk density or porosity, and soil temperature. Key words: frozen soils, hydraulic conductivity, bulk density, grain size distribution, unfrozen water content.
Soil restraint against oblique motion of pipelines in sand
Authors: Hsu Tung-Wen 
Published: March 2008

The soil restraint on pipelines due to oblique relative movement betwen the pipeline and dry loose sand was investigated. Model pipes 1.22 m long with diameters of 38.1, 76.2, 152.4, and 228.6 mm are obliquely moved from vertical to horizontal direction in the drag box to study the soil restraint of the oblique pipes with various relative velocities. All test results indicate that the dimensionless ultimate soil restraints have a power law relationship with the pipe velocity. The velocity exponent increases slightly with the oblique angle and embedded depth of the pipe. Furthermore, the soil restraint also increases with both the pipes oblique angle and embedded depth. Most of the increase in the soil restraint is associated with the oblique angles in the interval between 45 and 90°. The limit equilibrium model succesfully predicted the soil restraint of the pipe. Normailized forcedisplacement relationships of soilpipe interaction could be represented by two-constant hyperbolic equation. The findings show that the first constant value, a, increases, whereas the second value, b, decreases with the oblique angle, respectively. Key words: pipelines, soil restraint, oblique motion, sand.
Tracking Web spam with HTML style similarities
Authors: Urvoy Tanguy , Chauveau Emmanuel , Filoche Pascal , Lavergne Thomas 
Published: March 2008

Automatically generated content is ubiquitous in the web: dynamic sites built using the three-tier paradigm are good examples (e.g., commercial sites, blogs and other sites edited using web authoring software), as well as less legitimate spamdexing attempts (e.g., link farms, faked directories).
Those pages built using the same generating method (template or script) share a common “look and feel” that is not easily detected by common text classification methods, but is more related to stylometry.
In this work we study and compare several HTML style similarity measures based on both textual and extra-textual features in HTML source code. We also propose a flexible algorithm to cluster a large collection of documents according to these measures. Since the proposed algorithm is based on locality sensitive hashing (LSH), we first review this technique.
We then describe how to use the HTML style similarity clusters to pinpoint dubious pages and enhance the quality of spam classifiers. We present an evaluation of our algorithm on the WEBSPAM-UK2006 dataset.
Adaptive quality of service management for enterprise services
Authors: Gmach Daniel , Krompass Stefan , Scholz Andreas , Wimmer Martin , Kemper Alfons 
Published: March 2008

In the past, enterprise resource planning systems were designed as monolithic software systems running on centralized mainframes. Today, these systems are (re-)designed as a repository of enterprise services that are distributed throughout the available computing infrastructure. These service oriented architectures (SOAs) require advanced automatic and adaptive management concepts in order to achieve a high quality of service level in terms of, for example, availability, responsiveness, and throughput. The adaptive management has to allocate service instances to computing resources, adapt the resource allocation to unforeseen load fluctuations, and intelligently schedule individual requests to guarantee negotiated service level agreements (SLAs). Our AutoGlobe platform provides such a comprehensive adaptive service management comprising
—static service-to-server allocation based on automatically detected service utilization patterns,
—adaptive service management based on a fuzzy controller that remedies exceptional situations by automatically initiating, for example, service migration, service replication (scale-out), and
—adaptive scheduling of individual service requests that prioritizes requests depending on the current degree of service level conformance.
All three complementary control components are described in detail, and their effectiveness is analyzed by means of realistic business application scenarios.
Enhanced Expression of Rab27A Gene by Breast Cancer Cells Promoting Invasiveness and the Metastasis Potential by Secretion of Insulin-Like Growth Factor-II
Authors: Wang Jin-Song , Wang Fu-Bin , Zhang Qiang-Ge , Shen Zhen-Zhou , Shao Zhi-Ming 
Published: March 2008

Abstract
In addition to the functions of transporting melanosome in melanocytes and releasing contents of lytic granules in CTLs, Rab27A was recently shown to be involved in exocytosis of insulin and chromaffin granules in endocrine cells; it was also reported to be expressed in an exceptionally broad range of specialized secretory cells. As autocrine and paracrine cytokines are essential for invasion and metastasis in some solid tumors, blocking them may be an effective strategy to prevent tumor dissemination. In the present study, we show that Rab27A is associated with invasive and metastatic potentials of human breast cancer cells. The overexpression of Rab27A protein redistributed the cell cycle and increased the invasive and metastatic abilities in breast cancer cells both in vitro and in vivo. We also certified that Rab27A conferred the invasive and metastatic phenotypes on breast cancer cells by promoting the secretion of insulin-like growth factor-II (IGF-II), which regulates the expression of p16, vascular endothelial growth factor, matrix metalloproteinase-9, cathepsin D, cyclin D1, and urokinase-type plasminogen activator. These data provide functional evidence that Rab27A acts as a novel mediator of invasion and metastasis promotion in human breast cancer cells, at least in part, through regulating the secretion of IGF-II, suggesting that synergistic suppression of Rab27A and IGF-II activities holds a promise for preventing breast cancer invasion and metastasis. (Mol Cancer Res 2008;6(3):372–82)
Geldanamycin-Induced Down-Regulation of ErbB2 from the Plasma Membrane Is Clathrin Dependent but Proteasomal Activity Independent
Authors: Pedersen Nina Marie , Madshus Inger Helene , Haslekås Camilla , Stang Espen 
Published: March 2008

AbstractErbB2, a member of the epidermal growth factor receptor family, is overexpressed in a number of human cancers. In contrast to the epidermal growth factor receptor, ErbB2 is normally endocytosis resistant. However, ErbB2 can be down-regulated by inhibitors of heat shock protein 90, such as geldanamycin. We now show that geldanamycin induces endocytosis and lysosomal degradation of full-length ErbB2. We further report that the endocytosis of ErbB2 is dynamin and clathrin dependent. When ErbB2 was retained at the plasma membrane due to knockdown of clathrin heavy chain, the intracellular part of ErbB2 was degraded in a proteasomal manner. However, our data strongly suggest that proteasomal activity is not required for geldanamycin-induced endocytosis of ErbB2 in SKBr3 cells. Interestingly, however, proteasomal inhibitors retarded degradation of ErbB2, and electron microscopy analysis strongly suggested that proteasomal activity is required to sort internalized ErbB2 to lysosomes. Because geldanamycin derivatives and inhibitors of proteasomal activity are both used in experimental cancer treatment, knowledge of molecular mechanisms involved in geldanamycin-induced down-regulation of ErbB2 is important for future design of cancer treatment. (Mol Cancer Res 2008;6(3):491–500)
Glioma Regression In vitro and In vivo by a Suicide Combined Treatment
Authors: García-Escudero Vega , Gargini Ricardo , Izquierdo Marta 
Published: March 2008

Abstract
We present here a suicide therapy against malignant gliomas based on the transfer to tumor cells of a gene encoding a β-glucosidase, linamarase (lis), which in the presence of the innocuous substrate linamarin (lin) produces cyanide, blocking the mitochondrial respiratory chain. Dog glioma cells carrying the lis gene are thus sensitive to lin (IC50 of 250 μg/mL at 48 hours) and cell death is accompanied by mitochondrial fission and ATP depletion. The combination of lis/lin with an otherwise nontoxic level of glucose oxidase (GO) enhances the therapeutic potential (IC50 of 50 μg/mL at 48 hours). GO produces hydrogen peroxide, inducing oxidative damage and increasing cellular stress. We show here the antitumoral effect of the lis/lin/GO therapy in a canine glioma cell line and in a xenograft glioma model in nude mice. The synergic combination causes mitochondrial membrane depolarization and phosphatidylserine externalization and accelerates death by 48 hours. The lethal process is caspase independent; poly(ADP-ribose) polymerase 1 is not implicated; and there is no apoptosis-inducing factor translocation to the nucleus. The combined system induces autophagic cell death that can be rescued by 3-methyladenine and is characterized by the presence of double-membrane vesicles and punctate LC-3 pattern. (Mol Cancer Res 2008;6(3):407–17)
Epidermal Growth Factor Receptor vIII Expression in U87 Glioblastoma Cells Alters Their Proteasome Composition, Function, and Response to Irradiation
Authors: Kim Kwanghee , Brush James M. , Watson Philip A. , Cacalano Nicholas A. , Iwamoto Keisuke S. , McBride William H. 
Published: March 2008

Abstract
Little is known about the factors that influence the proteasome structures in cells and their activity, although this could be highly relevant to cancer therapy. We have previously shown that, within minutes, irradiation inhibits substrate degradation by the 26S proteasome in most cell types. Here, we report an exception in U87 glioblastoma cells transduced to express the epidermal growth factor receptor vIII (EGFRvIII) mutant (U87EGFRvIII), which does not respond to irradiation with 26S proteasome inhibition. This was assessed using either a fluorogenic substrate or a reporter gene, the ornithine decarboxylase degron fused to ZsGreen (cODCZsGreen), which targets the protein to the 26S proteasome. To elucidate whether this was due to alterations in proteasome composition, we used quantitative reverse transcription-PCR to quantify the constitutive (X, Y, Z) and inducible 20S subunits (Lmp7, Lmp2, Mecl1), and 11S (PA28α and β) and 19S components (PSMC1 and PSMD4). U87 and U87EGFRvIII significantly differed in expression of proteasome subunits, and in particular immunosubunits. Interestingly, 2 Gy irradiation of U87 increased subunit expression levels by 16% to 324% at 6 hours, with a coincident 30% decrease in levels of the proteasome substrate c-myc, whereas they changed little in U87EGFRvIII. Responses similar to 2 Gy were seen in U87 treated with a proteasome inhibitor, NPI0052, suggesting that proteasome inhibition induced replacement of subunits independent of the means of inhibition. Our data clearly indicate that the composition and function of the 26S proteasome can be changed by expression of the EGFRvIII. How this relates to the increased radioresistance associated with this cell line remains to be established. (Mol Cancer Res 2008;6(3):426–34)
The Critical Role of the Colony-Stimulating Factor-1 Receptor in the Differentiation of Myeloblastic Leukemia Cells
Authors: Hamilton John A. , Whitty Genevieve , Masendycz Paul , Wilson Nicholas J. , Jackson Jacob , De Nardo Dominic , Scholz Glen M. 
Published: March 2008

Abstract
How diverse stimuli control hemopoietic lineage development is unknown. An early event during induction of macrophage differentiation in the myeloblastic leukemia M1 cell line by different stimuli, such as leukemia inhibitory factor (LIF) and interleukin-6 (IL-6), is expression of the colony-stimulating factor-1 receptor (CSF-1R). We report that expression of active CSF-1R in M1 cells accelerated their subsequent terminal differentiation into macrophages in response to LIF and IL-6 when compared with cells lacking the CSF-1R or expressing the receptor with compromised kinase activity; however, there was no requirement for signaling through the CSF-1R, for example, via endogenous CSF-1, during the actual LIF-induced and IL-6–induced differentiation stage. Differences were noted in the signaling pathways downstream of the LIF receptor depending on the presence of the CSF-1R. Both LIF and IL-6 gave an additive response with CSF-1, consistent with LIF and IL-6 acting via a different signaling pathway (signal transducer and activator of transcription 3 dependent) than CSF-1 (extracellular signal-regulated kinase dependent). Based at least on this cell model, we propose that terminal macrophage differentiation involves a critical priming or deterministic phase in which signaling by the CSF-1R prepares a precursor population for subsequent rapid terminal macrophage differentiation by diverse stimuli. We also propose that expression and activation of the CSF-1R explain much prior literature on macrophage lineage commitment in M1 leukemic cells and may be important in controlling the progression of certain myeloid leukemias. (Mol Cancer Res 2008;6(3):458–67)
Cripto-1 Alters Keratinocyte Differentiation via Blockade of Transforming Growth Factor-β1 Signaling: Role in Skin Carcinogenesis
Authors: Shukla Anjali , Ho Yan , Liu Xin , Ryscavage Andrew , Glick Adam B. 
Published: March 2008

Abstract
Cripto-1 is an epidermal growth factor-Cripto/FRL1/Cryptic family member that plays a role in early embryogenesis as a coreceptor for Nodal and is overexpressed in human tumors. Here we report that in the two-stage mouse skin carcinogenesis model, Cripto-1 is highly up-regulated in tumor promoter–treated normal skin and in benign papillomas. Treatment of primary mouse keratinocytes with Cripto-1 stimulated proliferation and induced expression of keratin 8 but blocked induction of the normal epidermal differentiation marker keratin 1, changes that are hallmarks of tumor progression in squamous cancer. Chemical or genetic blockade of the transforming growth factor (TGF)-β1 signaling pathway using the ALK5 kinase inhibitor SB431542 and dominant negative TGF-β type II receptor, respectively, had similar effects on keratinocyte differentiation. Our results show that Cripto-1 could block TGF-β1 receptor binding, phosphorylation of Smad2 and Smad3, TGF-β–responsive luciferase reporter activity, and TGF-β1–mediated senescence of keratinocytes. We suggest that inhibition of TGF-β1 by Cripto-1 may play an important role in altering the differentiation state of keratinocytes and promoting outgrowth of squamous tumors in the mouse epidermis. (Mol Cancer Res 2008;6(3):509–16)
Good Career Moves: Life Stories of Daoist Nuns of the Twelfth and Thirteenth Centuries
Authors: Chao Shin-yi 
Published: March 2008

AbstractDaoist monasticism rose to prominence in China during the late twelfth and the mid-thirteenth centuries amid the turmoil of war and dynastic change. A particular Daoist monastic order emerged, called Quanzhen or 'Complete Perfection', which became popular and spread throughout China. A number of commemorative stone steles from the monasteries of the period have been preserved, and serve as the main sources for this article. The steles record the religious activities and experiences of female practitioners, some of whom rose to leading positions, as founders, abbesses, and managers of flourishing monasteries. The funding for these monasteries came from the donations of the lay followers whom they inspired. Within the monastic universe, they trained and ordained the next generation of clerics, and provided ritual services to the lay community as well. Toward the end of their careers, abbesses choose their successors from among their female disciples, and a lineage based on the master-disciple relationship took shape.
Kritische Bemerkungen zur Geschichte der religiösen Toleranz und zur Tradition der Lessing'schen Ringparabel
Authors: Dinzelbacher Peter 
Published: March 2008

AbstractAlthough the medieval tradition of the famous parable which stands in the centre of Lessing's Nathan der Weise is quite well known, the present writer holds that the older versions of this motive are usually misinterpreted, being habitually read in the light of the German poet's text written during the age of enlightenment. An analysis, however, of the original stories of Etienne de Bourbon, Busone, Boccaccio et al., shows that their real aim was to illustrate an aporia and the shrewdness necessary to escape from it, not to call for religious tolerance. Indeed, the latter idea grew out of the disasters of the Thirty Years' War only, and was nearly completely alien to the Middle Ages. The few exceptions (Wolfram von Eschenbach, Ramon Llull, Nicolaus Cusanus) — and their limitations — are briefly discussed.
The Cilician God Sandas and the Greek Chimaera: Features of Near Eastern and Greek Mythology Concerning the Plague
Authors: Mastrocinque Attilio 
Published: March 2008

AbstractA gem in the Museum of Castelvecchio (Verona) depicts the god Sandas of Tarsos with his terrible animal: the lion-goat. On the reverse side there is the inscription YOYO. The epigraphical and archaeological evidence from Anatolia, from Hittite to Hellenistic times, proves that Sandas was a underworld god protecting tombs and sending pestilences when angry. He was appeased by offerings to his terrible ministers, who were usually seven. Similarly Nergal or Erra (similar to Sandas) in Mesopotamia, and Sekhmet in Egypt had seven animal-headed terrible ministers, who were able to bring pestilences and death. A Hittite inscription mentions Yaya as Sandas' female partner. Her name is very similar to the Yoyo on the Verona gem. Sandas was identified with Heracles because of his relations with the underworld realms and his warlike features. The lion-goat of Tarsus was the model of Greek Chimaera. In fact the myth of Bellerophon took its place in Lycia and Cilicia. In Hellenistic age the original form of this monster was better known and therefore we find its typical features in Hellenistic and Roman sculptures and reliefs.
The First Documented Occurence of the God Yahweh? (Book of the Dead Princeton “Roll 5”)
Authors: Schneider Thomas 
Published: March 2008

AbstractThe article presents and discusses the proper name of the owner of a recently unfolded and mounted Book of the Dead papyrus from the late 18th or 19th dynasty (Princeton University Library, Pharaonic Roll 5). It is proposed that the name in question is a Northwest Semitic theophoric sentence name in Egyptian transcription, 'adōnī-rō'ē-yāh “My lord is the shepherd of Yah”. Whereas the name Yahweh has been known from Egyptian toponym lists of the New Kingdom, the present name would be the first documented occurence of the god Yahweh in his function as a shepherd of Yah, the short form of the tetragrammaton. The article also points to a new etymology of the divine name and the cultural significance of the evidence.
Serbo-Croatian Influences on Bosnian Spoken Judeo-Spanish
Authors: Papo Eliezer 
Published: March 2008

AbstractThe sweeping and far-reaching political, economical and demographical changes in Bosnia and Herzegovina at the end of 19th, beginning of the 20th century affected profoundly the linguistic situation of the country's Jewish, overwhelmingly Sephardic, minority. Having lost the unity with their brethren on Balkans, the Bosnian Jews had to rely more and more on their relations with other Bosnian ethno-religious communities. It is from this deepened contact with their Serbian, Muslim and Croatian neighbors on one side and from the constant need for new linguistic solutions, brought about by the ever changing reality, that Serbo-Croatian influences (once so superficial) started entering all the spheres of Bosnian Judeo-Spanish, its lexicon, morphology, phonology, syntax, and even grammar. The author analyzes those influences as they are, consciously or unconsciously, reflected in the literature produced by the members of the Sephardic Circle—the Sarajevo-based group of young and idealistic Sephardic intellectuals who tried to fight and prevent the oblivion of Judeo-Spanish language and culture.