bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationships between mental health and styles of help-seeking among care workers in comparison with the general population
Authors: Matsui Tomoko , Oba Hikaru , Uchida Ryosuke , Teraguchi Tsukasa 
Published: February 2025

Abstract

Background
Care workers in long-term nursing homes often experience burdens and a high rate of resignations. This study aimed to investigate the mental health of care workers and to examine the relationship between the tendency to seek help and their mental health, through a comparison with the general population to address this issue.

Methods
Online surveys were conducted separately with 273 care workers and 260 general public using a questionnaire platform. They were asked about their demographic variables, mental health [the Kessler Psychological Distress Scale (K6) and stressors], help-seeking styles (self-directed, excessive, and avoidant help-seeking), and usage on use of psychological support services. The analyses were performed except for missing responses.

Results
Overall, 132 (48.4%) care workers scored higher than the cutoff point on the K6. Regarding stressors identified by the care workers, most of the contents were related to work-related matters and workplace relationships, as demonstrated through qualitative analysis. Hierarchical multiple regression analysis showed that the interaction term between each help-seeking style and participant group was non-significant. Meanwhile, age (β = −0.116, p = 0.009), excessive help-seeking (β = 0.120, p = 0.014), and avoidant help-seeking (β = 0.331, p < 0.001) were associated with the K6.

Conclusion
This study revealed the tendency of care workers’ help-seeking behavior and its relationship to mental health. Improving care workers’ help-seeking skills and adjusting their work environment are essential for maintaining and enhancing their mental health.
Is t(11;14) in newly diagnosed multiple myeloma a favorable outcome in the novel agent era?
Authors: Li Ye , Deng Jingjing , Jian Yuan , Zhang Zhiyao , Chen Wenming 
Published: February 2025

Abstract

Background
t(11;14) is considered a standard risk factor in multiple myeloma (MM). However, recent studies suggested that its impact in the context of novel agents remained controversial.

Methods
This retrospective analysis examined the clinical profiles of 375 newly diagnosed patients with MM and compared the outcomes between those with t(11;14) and those with normal cytogenetics.

Results
The median progression-free survival (PFS) of the 84 patients with t(11;14) was 36 months (95% confidence interval (CI), 23.5–48.5), which was significantly shorter than the median PFS of 65 months (95% CI, 23.0–107.0) for the 59 patients with normal cytogenetics (p = 0.011). Median overall survival (OS) was not reached in either group (p = 0.977). When combined with 1q21 + , t(11;14) showed a trend toward poorer PFS (median PFS: 36 vs. 65 months; p = 0.130). In the presence of high-risk cytogenetics (HRCAs), t(11;14) was associated with a worse PFS (median PFS: 9 vs. 38 months, p = 0.015) and a trend toward shorter OS (median OS: 33 vs. 49 months, p = 0.096). Multivariate analysis indicated that t(11;14) was a poor prognostic factor for PFS. 1q21 + was a detrimental prognostic factor, particularly in the t(11;14) group. Autologous stem cell transplantation (ASCT) may be a beneficial treatment option for patients with t(11;14).

Conclusion
In this study, patients with MM with t(11;14) demonstrated poorer PFS than those with normal cytogenetics. Further investigations are required to evaluate the impact of t(11;14) in patients newly diagnosed with MM in the era of novel agents.
The First ABO Incompatible Kidney Transplantation from Living Donor in Slovakia – A Challenge How to Expand the Kidney Donor Pool
Authors: Bystricanova Andrea , Breza Jan , Javorkova Michaela , Cirbusova Martina , Cvoligova Marcela , Chrastina Martin , MARIS Juraj , Otavkova Jana , Zilinska Zuzana 
Published: February 2025

Abstract
Kidney transplantation is the most effective and cheapest treatment for terminal kidney failure. The transplantation programme is limited by the shortage of organs from deceased donors, therefore in many countries and in Slovakia a complementary programme of kidney transplantation from living donors has been established for years. Until recently, in addition to a negative cross-examination, an important condition for kidney transplantation was compatibility in the ABO system, but the development of elimination methods ensuring the removal of specific isoagglutinins and the availability of immunomodulatory and biologic drugs affecting the production of antibodies have made it possible to overcome the ABO barrier and safely transplant kidneys from ABO incompatible living donors. These transplantations offer hope, especially to those patients who have an ABO incompatible donor but have failed a kidney exchange program. We present a case of the first ABO incompatible living donor kidney transplantation in Slovakia, where a patient with blood group O received a kidney from his father with blood group B after desensitization preparation. The chances of success in the kidney exchange programme in the Slovak database were minimal. The aim of this case report is to draw attention to ABO incompatible living donor transplantation, which have the potential to increase the number of living donor kidney transplantation, including pre-emptive transplantation, and to reduce the waiting time for kidney transplantation in patients who do not have a living donor.
The EU’s neoliberal constitutionalism(s)
Authors: Grégoire Guillaume 
Published: February 2025

Abstract
Beyond their differences, the various currents of neoliberalism share a common legal agenda: economic constitutionalism. From ordoliberal Ordnungspolitik to new classical macroeconomics and public choice, from Hayek’s ‘constitution of liberty’ to Vanberg’s ‘constitutional political economy’, an institutional agenda has emerged around a number of key tenets: enhancing the competition between jurisdictions through (state and international) federalism; safeguarding the competitive functioning of the market through supra-legislative rules; limiting fiscal policies and disciplining public spending through balanced budget rules; neutralising monetary policy through independent and price stability-oriented central banks. These key tenets of neoliberal constitutionalism infuse the three layers of the European economic constitution: the fundamental freedoms of movement pave the way to normative competition between national legislations (microeconomic constitution); competition law guarantees the competitive structure of the market (mesoeconomic constitution); European Economic and Monetary Union implements the rules of budgetary discipline and monetary stability (macroeconomic constitution). This does not imply that the European Union is solely a neoliberal project or that the European Union’s current neoliberal path is irreversible. But it does at least raise questions about the actual room for manoeuvre left by this rigid ‘economic constitution’ to public institutions in dealing with the various current crises.
Feminine fox, not so feminine box: constraints on linguistic relativity effects for grammatical and conceptual gender
Authors: Brand James , Preininger Mikuláš , Kříž Adam , Ceháková Markéta 
Published: February 2025

Abstract
The influence of grammatical gender on conceptual representations of gender has proven to be a controversial topic in the linguistic relativity literature, with empirical evidence in support of the Linguistic Relativity Hypothesis being highly task and context-dependent, as well as being modulated by the type of items being investigated (animates/inanimates). In this paper, we take a megastudy approach in order to investigate differences in results based on explicit and implicit paradigms that modulate the role of language and gender in their design. We present analyses of three experiments focussing on participants (total N = 4,621) with a grammatically gendered L1 (Czech), a non-grammatically gendered L1 (English) and L1-Czech in L2-English, and on three distinct semantic categories – people, animals and inanimates (total Nitems = 1,208). Our results indicate that the most reliable effects of grammatical gender influencing conceptual gender (outside of the domain of people) are observed for items representing animals, with Czech participants showing congruency effects in both explicit and implicit paradigms, even in their L2. The evidence for effects on inanimates is substantially weaker and is highly restrained to explicit tasks. We discuss these results in relation to the Linguistic Relativity Hypothesis and highlight important methodological considerations for future research.
The Causal Effect of Affluence on Voter Turnout: New Evidence from Lottery Winnings
Authors: Geys Benny , Sørensen Rune J. 
Published: February 2025

Abstract
Affluent citizens commonly record higher election turnout than less affluent citizens. Yet, the causal effect of affluence on voter turnout remains poorly understood. In this article, we rely on Norwegian administrative data to estimate the impact of random, exogenous shocks in (unearned) income on individual-level voter turnout. Exploiting the random timing and size of lottery wins for identification, our main findings suggest that a lottery windfall in the years just before an election boosts individuals’ turnout probability by 1.6 to 1.9 percentage points. Crucially, these point estimates reflect only a small share of turnout differences observed across the income distribution. Hence, our findings strongly suggest that most of the commonly observed positive income-turnout associations do not reflect a causal relationship.
Multidimensional outcome of first-episode psychosis: a network analysis
Authors: Cuesta Manuel J , Gil-Berrozpe Gustavo J , Sánchez-Torres Ana M , Moreno-Izco Lucía , García de Jalón Elena , Peralta Víctor ,   SEGPEPs Group
Published: February 2025

Abstract

Background
Few studies have examined the long-term outcomes of first-episode psychosis (FEP) among patients beyond symptomatic and functional remission. This study aimed to broaden the scope of outcome indicators by examining the relationships between 12 outcomes of FEP patients at 20.9 years after their initial diagnosis.

Methods
At follow-up, 220 out of 550 original patients underwent a new assessment. Twelve outcomes were assessed via semistructured interviews and complementary scales: symptom severity, functional impairment, personal recovery, social disadvantage, physical health, number of suicide attempts, number of episodes, current drug use, dose-years of antipsychotics (DYAps), cognitive impairment, motor abnormalities, and DSM-5 final diagnosis. The relationships between these outcome measures were investigated using Spearman’s correlation analysis and exploratory factor analysis, while the specific connections between outcomes were ascertained using network analysis.

Results
The outcomes were significantly correlated; specifically, symptom severity, functioning, and personal recovery showed the strongest correlations. Exploratory factor analysis of the 12 outcomes revealed two factors, with 11 of the 12 outcomes loading on the first factor. Network analysis revealed that symptom severity, functioning, social disadvantage, diagnosis, cognitive impairment, DYAps, and number of episodes were the most interconnected outcomes.

Conclusion
Network analysis provided new insights into the heterogeneity between outcomes among patients with FEP. By considering outcomes beyond symptom severity, the rich net of interconnections elucidated herein can facilitate the development of interventions that target potentially modifiable outcomes and generalize their impact on the most interconnected outcomes.
Association between the functional brain network and antidepressant responsiveness in patients with major depressive disorders: a resting-state EEG study
Authors: Choi Kang-Min , Hwang Hyeon-Ho , Yang Chaeyeon , Jung Bori , Im Chang-Hwan , Lee Seung-Hwan 
Published: February 2025

Abstract

Background
Recent neuroimaging studies have demonstrated that the heterogeneous antidepressant responsiveness in patients with major depressive disorder (MDD) is associated with diverse resting-state functional brain network (rsFBN) topology; however, only limited studies have explored the rsFBN using electroencephalography (EEG). In this study, we aimed to identify EEG-derived rsFBN-based biomarkers to predict pharmacotherapeutic responsiveness.

Methods
The resting-state EEG signals were acquired for demography-matched three groups: 98 patients with treatment-refractory MDD (trMDD), 269 those with good-responding MDD (grMDD), and 131 healthy controls (HCs). The source-level rsFBN was constructed using 31 sources as nodes and beta-band power envelope correlation (PEC) as edges. The degree centrality (DC) and clustering coefficients (CCs) were calculated for various sparsity levels. Network-based statistic and one-way analysis of variance models were employed for comparing PECs and network indices, respectively. The multiple comparisons were controlled by the false discovery rate.

Results
Patients with trMDD were characterized by the altered dorsal attention network and salience network. Specifically, they exhibited hypoconnection between eye fields and right parietal regions (p = 0.0088), decreased DC in the right supramarginal gyrus (q = 0.0057), and decreased CC in the reward circuit (qs < 0.05). On the other hand, both MDD groups shared increased DC but decreased CC in the posterior cingulate cortex.

Conclusions
We confirmed that network topology was more severely deteriorated in patients with trMDD, particularly for the attention-regulatory networks. Our findings suggested that the altered rsFBN topologies could serve as potential pathologically interpretable biomarkers for predicting antidepressant responsiveness.
Implementation of the EU’s Health Technology Assessment regulation: where does existing methods guidance require concretization and what are the relevant methodological options?
Authors: Goetz Gregor , Schandelmaier Stefan , Busse Reinhard , Wild Claudia , Panteli Dimitra 
Published: February 2025

Abstract

Objectives
The EUnetHTA Core Model® is well-established in the HTA community. Some recommendations of corresponding guidance documents leave room for alternative methodological choices. Considering the new HTA regulation (HTAR), we aimed to identify needs for concretization (NCs) in EUnetHTA guidance and provide indicative methodological options.

Methods
We carried out a qualitative document analysis and structured group discussion. Twenty-two EUnetHTA documents were screened using transparent criteria. Identified NCs were classified into topics according to the PRISMA statement and presented to Austrian HTA practitioners (n = 11) during a structured group discussion. Participants rated NC’s importance. To identify potential solutions, selected key handbooks for generic (Cochrane) and HTA-specific (IQWIG/NICE) evidence synthesis were systematically reviewed and matching content was charted against the NCs.

Results
Thirty-two topics with varying numbers of NCs were identified, twenty-six during the screening process, and six from the group discussion. Most of the topics related to evidence synthesis methods (nine topics), evidence eligibility criteria (nine topics), risk of bias (three topics), and certainty assessment (three topics). Other topics related to information sources, search strategy, data collection process, data items, effect measures, and reporting bias. One or more methodological approaches and recommendations could be identified for each identified topic from the included methodological handbooks.

Conclusions
Our analysis identified a need for concretization in some EUnetHTA guidelines. The structured overview of methodological options may support HTA doers in adapting and applying the guidelines to the national and local practical context.
The relationships among L2 fluency, intelligibility, comprehensibility, and accentedness
Authors: Chau Tuc , Huensch Amanda 
Published: February 2025

Abstract
Fluency, intelligibility, comprehensibility, and accentedness are important dimensions of second language (L2) pronunciation proficiency representing global, listener-based intuitions. This study meta-analyzed 49 reports from 1995 to 2023, examining 141 effect sizes (Pearson r) to understand their relationships and possible moderators. Three-level meta-analysis models showed weighted mean correlations of .82, .75, .62, .57, and .32 for fluency/comprehensibility, comprehensibility/accentedness, fluency/accentedness, intelligibility/comprehensibility, and intelligibility/accentedness, respectively. Task types moderated correlations for fluency/accentedness, intelligibility/comprehensibility, and intelligibility/accentedness, with controlled tasks leading to higher correlations. Ratings of multiple dimensions by the same listeners tended to result in weaker correlations for fluency/comprehensibility and comprehensibility/accentedness. The findings imply that having an accent does not mean being unintelligible and support prioritizing intelligible and comprehensible speech over accent reduction. The study also highlights an over-reliance on first language speaker norms in L2 pronunciation research and advocates for more transparent reporting.
Adapting the Flexible Farrington Algorithm for daily situational awareness and alert system to support public health decision-making during the SARS-CoV-2 epidemic in England
Authors: Simms Ian , Charlett André , Colón-González Felipe J , Blomquist Paula B. , Lake Iain R. , Zaidi Asad , Shadwell Stephanie , Sedgwick James , Paranthaman Karthik , Vivancos Roberto 
Published: February 2025

Abstract
The Flexible Farrington Algorithm (FFA) is widely used to detect infectious disease outbreaks at national/regional levels on a weekly basis. The rapid spread of SARS-CoV-2 alongside the speed at which diagnostic and public health interventions were introduced made the FFA of limited use. We describe how the methodology was adapted to provide a daily alert system to support local health protection teams (HPTs) working in the 316 English lower-tier local authorities. To minimize the impact of a rapidly changing epidemiological situation, the FFA was altered to use 8 weeks of data. The adapted algorithm was based on reported positive counts using total tests as an offset. Performance was assessed using the root mean square error (RMSE) over a period. Graphical reports were sent to local teams enabling targeted public health action. From 1 July 2020, results were routinely reported. Adaptions accommodated the impact on reporting because of changes in diagnostic strategy (introduction of lateral flow devices). RMSE values were relatively small compared to observed counts, increased during periods of increased reporting, and were relatively higher in the northern and western areas of the country. The exceedance reports were well received. This presentation should be considered as a successful proof-of-concept.
Why We Should Be Experientialists about Suffering
Authors: Brady Michael S. 
Published: February 2025

Abstract
Increased interest in suffering has given rise to different accounts of what suffering is. This paper focuses the debate between experientialists and non-experientialists about suffering. The former hold that suffering is necessarily experiential—for instance, because it is necessarily unpleasant or painful; the latter deny this—for instance, because one can suffer when and because one’s objective properties are damaged, even if one does not experience this. After surveying how the two accounts fare on a range of issues, the paper presents a decisive argument in favor of experientialism. The central claim is that non-experientialist accounts cannot accommodate cases of suffering that are virtuous and that directly contribute to some objective good.
‘Why don’t you…’: R.J. Morris and the European Association for Urban History
Authors: Ewen Shane 
Published: February 2025

Abstract
Bob Morris was elected as president of the European Association for Urban History (EAUH) ahead of its 2002 conference in Edinburgh. Bob’s presidency, and the Edinburgh conference specifically, took place at an important point in the development of urban history within Europe and further afield. First, the programme reveals several emerging themes and topics of interest that have since shaped the sub-field in new and innovative ways. Second, Bob’s informal and collegial approach towards networking is reflected in the decision to place the EAUH on a quasi-formal constitutional basis. Both of these developments reflect, in part, Bob’s own research interests, as well as the sub-field’s welcoming approach to younger researchers, including taught and research postgraduate students, interested in networking with more established scholars.
Collection and In Situ Analyses of Regolith Samples by the Mars 2020 Rover: Implications for Their Formation and Alteration History
Authors: Hausrath E. M. , Sullivan R. , Goreva Y. , Zorzano M. P. , Vaughan A. , Cousin A. , Siljeström S. , Sharma S. , Shumway A. O. , Kizovski T. , VanBommel S. J. , Tice M. , Knight A. , Martinez G. , Vicente‐Retortillo A. , Mandon L. , Adcock C. T. , Madariaga J. M. , Población I. , Johnson J. R. , Lasue J. , Gasnault O. , Randazzo N. , Cardarelli E. L. , Kronyak R. , Bechtold A. , Paar G. , Udry A. , Forni O. , Bedford C. C. , Carman N. A. , Bell J. F. , Benison K. , Bosak T. , Brown A. , Broz A. , Calef F. , Clark B. C. , Cloutis E. , Czaja A. D. , Fornaro T. , Fouchet T. , Golombek M. , Gómez F. , Herd C. D. K. , Herkenhoff K. , Jakubek R. S. , Jandura L. , Martinez‐Frias J. , Mayhew L. E. , Meslin P.‐Y. , Newman C. E. , Núñez J. I. , Poulet F. , Royer C. , Russell P. , Sephton M. A. , Sharma S. K. , Shuster D. , Simon J. I. , Tirona I. , Wiens R. C. , Weiss B. P. , Williams A. J. , Williford K. , Wolf Z. U. ,   the Regolith Working Group
Published: February 2025

AbstractThe Perseverance rover has sampled mm‐size lithic fragments containing olivine likely from at least two source regions from the surface of an inactive megaripple surface, and fine‐grained material from the surface and to a depth of ∼4–6 cm. Some of the mm‐size grains lack a coherent diffraction pattern measured by PIXL, consistent with the presence of poorly ordered secondary phases that have been altered. Analysis of these materials on Earth will allow examination of materials that have experienced aqueous, potentially habitable environments that could contain biosignatures. Fluorescence of three different patterns was detected, consistent with inorganic emissions from silica defects or rare earth elements in certain mineral phases, although organic origin cannot be excluded. Analysis of Autofocus Context Imager and Wide Angle Topographic Sensor for Operations and eNgineering images of the subsurface material and MEDA thermal inertia measurements indicate average grain sizes of ∼125 and ∼150 μm, respectively, for the bulk material within the megaripple. The fine‐grained material in the sampling location indicates chemical compositions similar to previously proposed global components as well as airfall dust. In situ and associated atmospheric measurements provide evidence of recent processes likely including water vapor in soil crust formation. The sampled material will therefore help elucidate the formation of Martian soils; current surface‐atmosphere interactions; the composition, shape, and size distribution of dust grains valuable for studies of past and present Martian climate and for assessing potential health and other risks to human missions; and ancient, aqueously altered environments that could have been habitable, and, if Mars contained life, possibly contain biosignatures.