bluuebunny/crossref_metadata_2025_split huggingface dataset:
The oviposition preference and offspring performance of Aethina tumida (Coleoptera: Nitidulidae)
Authors: Yang Xinyu , Wang Mei , Gu Yifan , Han Wensu , Li Xiaoyu , Li Xiang , Zhong Yihai , Gao Jinglin 
Published: April 2024

Abstract
Given the rapid spread and potential harm caused by the small hive beetle, Aethina tumida (Coleoptera: Nitidulidae) in China, it has become imperative to comprehend the developmental biology of this invasive species. Currently, there is limited knowledge regarding the impact of A. tumida female oviposition site preference on larval growth and development. To examine this, we investigated the ovipositional preference of adult female A. tumida on bee pupae, beebread, banana, and honey through a free choice test. Furthermore, we assessed the impact of these food resources on offspring performance, which included larval development time, survival, wandering larvae weight, emerged adult body mass, reproduction, and juvenile hormone titer. Our results showed that A. tumida females exhibited a strong preference for ovipositing on bee pupae compared to other diets, while showing reluctance toward honey. Moreover, A. tumida larvae that were fed on bee pupae displayed accelerated growth compared to those fed on other diets. Furthermore, A. tumida fed on bee pupae exhibited higher weights for wandering larvae, and emerged adult, increased pupation rates, enhanced fecundity and fertility, as well as a larger number of unilateral ovarioles during the larval stage when compared to those fed on other diets. Overall, the results indicate that the oviposition preferences of A. tumida females are adaptive, as their choices can enhance the fitness of their offspring. This finding aligns broadly with the hypothesis of oviposition preference and larval performance. This study can provide a foundation for the development of attractants aimed at promoting the oviposition of the A. tumida adults.
Downside and Upside Uncertainty Shocks
Authors: Forni Mario , Gambetti Luca , Sala Luca 
Published: April 2024

Abstract
An increase in uncertainty is not contractionary per se. What is contractionary is a widening of the left tail of the GDP growth forecast distribution, the downside uncertainty. On the contrary, an increase of the right tail, the upside uncertainty, is mildly expansionary. The reason why uncertainty shocks have been previously found to be contractionary is because movements in downside uncertainty dominate existing empirical measures of uncertainty. The results are obtained using a new econometric approach that combines quantile regressions and structural vector autoregressions (VARs).
Postoperative anticoagulation management using subcutaneous unfractionated heparin for a patient with nonbacterial thrombotic endocarditis: a case report
Authors: Mine Hiroki , Saku Kosuke , Takagi Kazuyoshi , Nohara Shoichiro , Hiromatsu Shinichi , Fukumoto Yoshihiro , Tayama Eiki 
Published: April 2024

Abstract
Nonbacterial thrombotic endocarditis (NBTE) presents nonbacterial vegetation on cardiac valves. NBTE requires appropriate anticoagulant therapy to prevent recurrence after surgery. However, there has not yet been established evidence for anticoagulant therapy in NBTE, and low molecular weight heparin is not approved in Japan. We present a case of NBTE that was successfully managed with anticoagulant therapy using subcutaneous unfractionated heparin. A 59-year-old woman was diagnosed with NBTE on the mitral and tricuspid valve associated with breast cancer, underwent valve replacement. Warfarin and continuous intravenous unfractionated heparin were started. However, disseminated intravascular coagulation occurred after heparin was discontinued. Continuous intravenous unfractionated heparin injection was resumed immediately, and subcutaneous unfractionated heparin was administered before discharge. Postoperative echocardiography revealed no vegetation on the prosthetic valves thereafter. Subcutaneous unfractionated heparin therapy is useful to prevent the recurrence of NBTE as the anticoagulation in outpatients.
Bayesian Quantile Regression Models for Complex Survey Data Under Informative Sampling
Authors: Nascimento Marcus L , Gonçalves Kelly C M 
Published: April 2024

Abstract
The interest in considering the relation among random variables in quantiles instead of the mean has emerged in various fields, and data collected from complex survey designs are of fundamental importance to different areas. Despite the extensive literature on survey data analysis and quantile regression models, research papers exploring quantile regression estimation accounting for an informative design have primarily been restricted to a frequentist framework. In this paper, we introduce different Bayesian methods relying on the survey-weighted estimator and the estimating equations. A model-based simulation study evaluates the proposed methods compared to alternative approaches and a naïve model fitting ignoring the informative sampling design under different scenarios. In addition, we illustrate and conduct a prior sensitivity analysis in a design-based simulation study that uses data from Prova Brasil 2011.
Malaria cases in China acquired through international travel, 2013–2022
Authors: Zhu Yan , Restrepo Angela Cadavid , Wang Hai-Bo , Mills Deborah J , Liang Rong-Rong , Liu Zhi-Bin , Lau Colleen L , Furuya-Kanamori Luis 
Published: April 2024

Abstract

Background
Despite the World Health Organization certifying China malaria-free in 2021, the risk of local transmission caused by imported malaria cases remains a significant clinical and public health issue. It is necessary to present the changing trends of malaria in China and discuss the role of travel medicine services in consolidating malaria elimination.

Methods
This study systematically reviewed articles and reports related to human malaria from 2013 to 2022 published in international and Chinese databases. Data on malaria (i.e. number of cases, Plasmodium spp., diagnostic method, country of acquisition, provinces with high risk of re-introduction and transmission) were collected and synthesized, then summarized using descriptive statistics.

Results
Overall, 24 758 cases of malaria (&gt;99.5% laboratory confirmed, &gt; 99.2% imported, 0.5% fatal) were reported in China from 2013 to 2022, with a downward trend over the years (4128 cases in 2013 compared to 843 cases in 2022; χ2 trend P = 0.005). The last locally acquired case was reported in 2017. Plasmodium falciparum (65.5%) was the most common species identified, followed by P. vivax (20.9%) and P. ovale (10.0%). Two P. knowlesi cases were also identified in 2014 and 2017 in returned travellers from Malaysia and Indonesia, respectively. The most common countries for malaria acquisition were Ghana, Angola and Myanmar. Plasmodium vivax was mainly detected in returned travellers from Myanmar, while P. falciparum and P. ovale were detected in travellers from sub-Saharan Africa. Imported cases were mainly reported in Yunnan, Jiangsu, Sichuan, Guangxi, Shandong, Zhejiang and Henan provinces, where large numbers of Chinese people travel overseas for work.

Conclusion
Returned travellers from malaria-endemic countries pose a significant risk of malaria re-introduction to China. Travel medicine should be strengthened to improve the capacity and accessibility of both pre- and post-travel services, including malaria prophylaxis and prompt diagnosis of illness in returned travellers.
Development of quality indicators for pregnancy and childbirth in patients with systemic lupus erythematosus
Authors: Hatano Mika , Yajima Nobuyuki , Yanai Ryo , Ishii Sho , Tsujimoto Yasushi , Azuma Teruhisa , Atsumi Tatsuya , Kaneko Yuko , Kameda Hideto , Kuwana Masataka , Tanaka Yoshiya , Nakagawa Shiori , Nakajima Ayako , Hiramatsu Yuri , Fujita Daisuke , Miyamae Takako , Murashima Atsuko 
Published: April 2024

ABSTRACT

Objectives
A quality indicator (QI) for the treatment of systemic lupus erythematosus (SLE) during pregnancy and childbirth that is useful for sharing standard treatment policies has not yet been developed. This study aimed to develop a QI for SLE associated with pregnancy and childbirth.

Methods
To identify candidate QIs, we conducted a systematic literature review on the development of QIs for SLE related to pregnancy and childbirth and on clinical practice guidelines. Candidate QI items were extracted from the final selected articles, and a first evaluation, panel meeting, and second evaluation were conducted to determine whether the candidate items were appropriate as QIs. Items for which all panel members reached a consensus were designated pregnancy and childbirth-related SLE QIs.

Results
Four articles on SLE QI development and 28 practice guidelines were listed through abstract/text screening. Based on these studies, 52 candidate QIs were extracted that were limited to items related to pregnancy and childbirth and 41 items were selected on which all panel members agreed.

Conclusion
We developed pregnancy-related SLE QIs using the RAND/UCLA method and selected 41 items, which could be used clinically.
Real-world clinical decisions of physicians in the management of Takayasu arteritis and giant cell arteritis in Japan: A cross-sectional web questionnaire survey
Authors: Abe Yoshiyuki , Fujii Takao , Miyawaki Yoshia , Sugihara Takahiko , Uchida Haruhito A , Maejima Yasuhiro , Watanabe Yoshiko , Hashimoto Takuya , Miyamae Takako , Nakaoka Yoshikazu , Harigai Masayoshi , Tamura Naoto 
Published: April 2024

ABSTRACT

Objectives
The aim is to access the real-world clinical management of physicians who treat Takayasu arteritis (TAK) and giant cell arteritis (GCA) after the publication of the Japanese Circulation Society (JCS) 2017 Guidelines for the Management of Vasculitis Syndrome.

Methods
This descriptive, cross-sectional study utilized self-administered electronic questionnaires, which were answered in February 2022 by physicians treating TAK or GCA and registered with Macromill Inc.

Results
The 329 survey respondents were enrolled. The 2017 JCS Guidelines were the most commonly referenced information source for resolving clinical questions, accessed by 70% of respondents. Ophthalmoscopy was performed in only 50% of patients with TAK and in 70% for GCA. The median percentages of patients who underwent 18F-fluorodeoxyglucose-positron emission tomography/computed tomography for TAK and GCA patients were 23% and 20% at diagnosis, respectively, and 10% each at follow-up within 12 months. Tocilizumab was the most frequently used medication in combination with glucocorticoids for both TAK and GCA, especially in remission induction therapy for relapsed patients.

Conclusions
The majority of physicians treating TAK and GCA referred to the 2017 JCS guidelines. This report clarified the current clinical practice for large vessel vasculitis in Japan, providing information for the next revision of the guidelines.
Trading permits and informal entrepreneurship: evidence from South Africa
Authors: Balde Racky 
Published: April 2024

Abstract
We present an empirical analysis of the relationship between trading permits, informal entrepreneurship and unemployment. We exploit a unique regulatory framework of the informal sector in South Africa to estimate the effects of trading permits in the informal sector using individual panel data. To provide a causal effect of these regulations, we apply a difference-in-difference strategy. Trading permits decreased informal entrepreneurship and informal trading by respectively 11.5 per cent and 9.6 per cent for those who were working in the informal sector. We investigate potential indirect effects on formal entrepreneurship, unemployment, and informal wage employment. The adoption of trading permits in the informal sector significantly increases the probability of being unemployed by 4.5 per cent and significantly decreases the probability of being informally employed by 15.5 per cent for those who were in the informal sector. The results suggest that a policy increasing the costs of informality might reduce informality but at the cost of rising unemployment.
Characteristics of contemporary health research practice: A shift from ivory tower to collaborative power
Authors: Wadsworth Daniel P , Craswell Alison , Ward Andy , Tulloch Kristen , Schaumberg Mia A , Stoner Lee , Meredith Pamela J , Askew Christopher D 
Published: April 2024

Abstract
The academic world is rapidly changing due to multiple influences, including COVID-19, technological advancement, tertiary competition, shifting government policies, and emerging research practices and priorities. Given this rapidly changing tertiary-education landscape, added importance is placed on the need for emerging research leaders to understand contemporary research practices which likely exceeds the skills displayed by their supervisors and mentors. Consequently, reflecting on 80+ years of collective post-PhD research experience, we identify and discuss six common characteristics of contemporary health research practice, with the aim of guiding and empowering higher degree by research students and emerging early career researchers as they develop their research identities and shape their approaches and values on the path to becoming research leaders in health. Indicative of today’s dynamic and exacting research environment, we propose that best practice contemporary health research should be: Diverse; Creative; Collaborative; Authentic; Respectful; and, Trusting. By understanding a diverse range of research approaches, and through working in collaborative and creative teams, diversity of thought, approach, and methods can become a cornerstone of practice. By blending this understanding with questions and research approaches that facilitate the pathway of translation uptake for the next-user, emerging research leaders can deliver authentic research with the requisite ingredients for impact.
Mothers’ and fathers’ neural responses toward gender-stereotype violations by their own children
Authors: Portengen Christel M , van Baar Anneloes L , Endendijk Joyce J 
Published: April 2024

Abstract
Gender stereotypes facilitate people’s processing of social information by providing assumptions about expected behaviors and preferences. When gendered expectations are violated, people often respond negatively, both on a behavioral and neural level. Little is known about the impact of family kinship on the behavioral and neural reactions to gender-stereotype violations. Therefore, we examined whether parents show different responses when gender stereotypes are violated by their own children vs unknown children. The sample comprised 74 Dutch families with a father (Mage = 37.54), mother (Mage = 35.83), son, and daughter aged 3–6 years. Electroencephalography measurements were obtained while parents viewed pictures of their own and unknown children paired with toy or problem behavior words that violated or confirmed gender stereotypes. In half of the trials, parents evaluated the appropriateness of toy–gender and behavior–gender combinations. Parents showed stronger late positive potential amplitudes toward gender stereotype-violating behaviors by own children compared to unknown children. Moreover, parents’ P1 responses toward gender stereotype-violating child behaviors were stronger for boys than for girls and for parents who evaluated gender-stereotype violations as less appropriate than gender-stereotype confirmations. These findings indicated that gender-stereotype violations by parents’ own children are particularly salient and viewed as less appropriate than gender-stereotype confirmations.
Disrupted cognitive and affective empathy network interactions in autistic children viewing social animation
Authors: Guo Xinrong , Xu Chuanyong , Chen Jierong , Wu Zhiliu , Hou Shumeng , Wei Zhen 
Published: April 2024

Abstract
Empathy can be divided into two core components, cognitive empathy (CE) and affective empathy (AE), mediated by distinct neural networks. Deficient empathy is a central feature of autism spectrum conditions (ASCs), but it is unclear if this deficit results from disruption solely within empathy networks or from disrupted functional integration between CE and AE networks. To address this issue, we measured functional connectivity (FC) patterns both within and between empathy networks in autistic children (4–8 years, n = 31) and matched typically developing (TD) children (n = 26) using near-infrared spectroscopy during the presentation of an animated story evoking CE and AE. Empathy and social communication ability were also assessed using the Empathy Quotient/Systemizing Quotient (EQ/SQ) and Social Responsiveness Scale, respectively. The results showed that the FC in the AE network of autistic children did not differ from the TD group across conditions; however, the ASC group showed weaker FC in the CE network under the CE condition and weaker FC between networks when processing AE information, the latter of which was negatively correlated with EQ scores in ASC. The empathy defect in ASC may involve abnormal integration of CE and AE network activities under AE conditions.
Among crises: how businesspeople built expectations of resilience in the face of COVID-19
Authors: Sendroiu Ioana 
Published: April 2024

Abstract
Interviews with 60 businesspeople coping with COVID-19 show that they elaborate the pandemic with reference to other crises they have faced. A model of sensemaking among crises is put forward, conceptualizing crises as recurrent, rather than singular or continuous. Among crises, comparisons to past experiences help make sense of the present situation: businesspeople who perceived COVID-19 to have analogues to crises they had (successfully) faced before felt hopeful about their ability to cope with the pandemic, while those who insisted that the pandemic was without precedent were more pessimistic than their peers. In this way, crises enter cultural repertoires, helping to make sense of unsettled times and even underpinning expectations of resilience. This process is an integral part of the entrepreneurial story: given cultural repertoires replete with narratives of virtuous economic actors successfully surmounting crises and managing risk, it is among crises that businesspeople either substantiate or challenge such beliefs.
“There’s So Much That They’re Enduring”
Authors: Kata Anna , Dillon Ellis C , Christina Keny RN , Yank Veronica , Covinsky Kenneth E , Raue Patrick J , Sandhu Harleen K , Tang Victoria L 
Published: April 2024

Objective:
This qualitative study aimed to explore the psychosocial experience of older adults undergoing major elective surgery from the perspective of both the patient and family caregiver.

Summary Background Data:
Older adults face unique psychological and social vulnerabilities that can increase susceptibility to poor health outcomes. How these vulnerabilities influence surgical treatment and recovery is understudied in the geriatric surgical population.

Methods:
Adults aged 65 and older undergoing a high-risk major elective surgery at the University of California, San Francisco and their caregivers were recruited. Semi-structured interviews were conducted at three time points: 1-2 weeks before surgery, and at 1- and 3-months following surgery. An inductive qualitative approach was used to identify underlying themes.

Results:
Twenty-five older adult patients (age range 65-82 years, 60% male) and 11 caregivers (age range 53-78 years, 82% female) participated. Three themes were identified. First, older surgical patients experienced significant challenges to emotional well-being both before and after surgery, which had a negative impact on recovery. Second, older adults relied on a combination of personal and social resources to navigate these challenges. Lastly, both patients and caregivers desired more resources from the healthcare system to address “the emotional piece” of surgical treatment and recovery.

Conclusions:
Older adults and their caregivers described multiple overlapping challenges to emotional well-being that spanned the course of the perioperative period. Our findings highlight a critical component of perioperative care with significant implications for the recovery of older surgical patients.
Senolytic therapy combining Dasatinib and Quercetin restores the chondrogenic phenotype of human osteoarthritic chondrocytes by promoting the release of pro-anabolic mediators
Authors: Maurer Svenja , Kirsch Valeria , Ruths Leonie , Brenner Rolf E. , Riegger Jana 
Published: April 2024

AbstractCellular senescence is associated with various age-related disorders and is assumed to play a major role in the pathogenesis of osteoarthritis (OA). Based on this, we tested a senolytic combination therapy using Dasatinib (D) and Quercetin (Q) on aged isolated human articular chondrocytes (hACs), as well as in OA-affected cartilage tissue (OARSI grade 1-2). Stimulation with D+Q selectively eliminated senescent cells in both, cartilage explants and isolated hAC. Furthermore, the therapy significantly promoted chondroanabolism, as demonstrated by increased gene expression levels of COL2A1, ACAN, and SOX9, as well as elevated collagen type II and glycosaminoglycan biosynthesis. Additionally, D+Q treatment significantly reduced the release of SASP factors (IL6, CXCL1). RNA sequencing analysis revealed an upregulation of the anabolic factors, inter alia, FGF18, IGF1, and TGFB2, as well as inhibitory effects on cytokines and the YAP-1 signaling pathway, explaining the underlying mechanism of the chondroanabolic promotion upon senolytic treatment. Accordingly, stimulation of untreated hAC with conditioned medium of D+Q-treated cells similarly induced the expression of chondrogenic markers. Detailed analyses demonstrated that chondroanabolic effects could be mainly attributed to Dasatinib, while monotherapeutical application of Quercetin or Navitoclax did not promote the chondroanabolism. Overall, D+Q therapy restored the chondrogenic phenotype in OA hAC most likely by creating a pro-chondroanabolic environment through the reduction of SASP factors and upregulation of growth factors. This senolytic approach could therefore be a promising candidate for further testing as a disease-modifying osteoarthritis drug.
SRSF2 is a key player in orchestrating the directional migration and differentiation of MyoD progenitors during skeletal muscle development
Authors: Sha Rula , Guo Ruochen , Duan Huimin , Peng Qian , Yuan Ningyang , Wang Zhenzhen , Li Zhigang , Xie Zhiqin , You Xue , Feng Ying 
Published: April 2024

AbstractSRSF2 plays a dual role, functioning both as a transcriptional regulator and a key player in alternative splicing. The absence of SRSF2 in MyoD+ progenitors resulted in perinatal mortality in mice, accompanied by severe skeletal muscle defects. SRSF2 deficiency disrupts the directional migration of MyoD progenitors, causing them to disperse into both muscle and non-muscle regions. Single-cell RNA-sequencing analysis revealed significant alterations in SRSF2-deficient myoblasts, including a reduction in extracellular matrix components, diminished expression of genes involved in ameboid-type cell migration and cytoskeleton organization, mitosis irregularities, and premature differentiation. Notably, one of the targets regulated by SRSF2 is the serine/threonine kinase Aurka. Knockdown of Aurka led to reduced cell proliferation, disrupted cytoskeleton, and impaired differentiation, reflecting the effects seen with SRSF2 knockdown. Crucially, the introduction of exogenous Aurka in SRSF2-knockdown cells markedly alleviated the differentiation defects caused by SRSF2 knockdown. Furthermore, our research unveiled the role of SRSF2 in controlling alternative splicing within genes associated with human skeletal muscle diseases, such as BIN1, DMPK, FHL1, and LDB3. Specifically, the precise knockdown of the Bin1 exon17-containing variant, which is excluded following SRSF2 depletion, profoundly disrupted C2C12 cell differentiation. In summary, our study offers valuable insights into the role of SRSF2 in governing MyoD progenitors to specific muscle regions, thereby controlling their differentiation through the regulation of targeted genes and alternative splicing during skeletal muscle development.