bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transplant nephropathology: Wherefrom, wherein, and whereto
Authors: Solez Kim , Eknoyan Garabed 
Published: April 2024

AbstractRenal pathology is a relatively recent entry in nephrology. While diseases of the kidney are old, their study began in the 19th century with the report of Richard Bright of the lesions of end‐stage kidney disease. Its easy diagnosis from albuminuria soon elevated Bright's nephritis into a leading cause of death. The transformative events in the care of these cases were renal replacement therapy that converted a fatal into a chronic disease, and kidney biopsy that allowed study of the course and pathogenesis of kidney disease. Apart from its fundamental contributions to clinical nephrology, biopsy of renal allografts became an integral component of the evaluation and care of kidney transplant recipients. The Banff transplant pathology conferences launched in 1991 led to developing the classification of allograft pathology into an essential element in the evaluation, treatment, and care of allograft recipients with spirit of discovery. That success came at the cost of increasing complexity leading to the recent realization that it may need the refinement of its consensus‐based system into a more evidence‐based system with graded statements that are easily accessible to the other disciplines involved in the care of transplanted patients. Collaboration with other medical disciplines, allowing public comment on meeting reports, and incorporation of generative artificial intelligence (AI) are important elements of a successful future. The increased pace of innovation brought about by AI will likely allow us to solve the organ shortage soon and require new classifications for xenotransplantation pathology, tissue engineering pathology, and bioartificial organ pathology.
Feeling loved in mixed‐gender adolescent romantic relationships in the face of daily stress and support: A dyadic diary study
Authors: Ha Thao , Iida Masumi , Quiroz Selena I. , Maras Olivia , Savord Andrea 
Published: April 2024

AbstractA profound developmental experience is the emergence of adolescent romantic relationships and first feelings of love. However, the daily nature of feeling loved in adolescents’ everyday lives is poorly understood. We investigated how daily stress severity was associated with adolescents’ levels of feeling loved and whether romantic partner support moderated these associations. Furthermore, we investigated this for non‐interpersonal and interpersonal stressors. N = 97 mixed‐gender adolescent romantic couples (age M = 16.38, SD = 1.02) from an ethnically diverse sample (42.2% Hispanic/Latino/a/x, 44.7% White) participated in dyadic diary assessments twice a week for 12 consecutive weeks. Both partners independently completed open‐ended questions about a daily stressor, indicating stress severity, perceived partner support, and feeling loved. Daily stressors were coded for non‐interpersonal and various types of interpersonal stressors. Results from the dyadic multilevel model showed that days with lower than average support from a romantic partner amplify the adverse effects of stress severity on feeling loved, especially when the partner is involved in the stressor. We discuss the spillover of stress in romantic relationships and the stress‐buffering functions of adolescent romantic partner support. Adolescent romantic partners are potentially essential regulators of stress, increasing adolescents’ feelings of love.Research Highlights
Romantic love is central in adolescents’ lives; we showed that adolescents generally feel loved by romantic partners.
Feeling loved fluctuates daily as adolescents feel less loved on stressful days.
However, when adolescents perceive their partner as supportive, there is no association between stress and feeling loved. Partner support is protective for feeling loved.
The current study provides essential insights into when adolescents and why adolescents feel loved.
Baby Observational Selective Control AppRaisal (BabyOSCAR): Convergent and discriminant validity and reliability in infants with and without spastic cerebral palsy
Authors: Sukal‐Moulton Theresa , Barbosa Vanessa Maziero , Sargent Barbara , Boswell Lynn , de Regnier Raye‐Ann , Bos Arend F. , Peyton Colleen 
Published: April 2024

AbstractAimTo describe the development of an observational measure of spontaneous independent joint motion in infants with spastic cerebral palsy (CP), the Baby Observational Selective Control AppRaisal (BabyOSCAR), and to test its convergent validity and reliability.MethodA retrospective sample of 75 infants (45 with spastic CP and 30 without CP) at 3 months of age were scored with the BabyOSCAR and compared with diagnosis of spastic CP, limbs affected, and Gross Motor Function Classification level at 2 years of age or later for convergent validity using t‐tests, Kruskal–Wallis tests, and Spearman's rank correlation coefficients. BabyOSCAR interrater and test–retest reliability was also evaluated using intraclass correlation coefficients.ResultsInfants with spastic CP had significantly lower BabyOSCAR scores than children without CP (p < 0.001) and scores were significantly correlated with Gross Motor Function Classification System levels (p < 0.001). Children with unilateral CP had significantly higher asymmetry scores than children with bilateral CP or no CP (p < 0.01). Interrater and test–retest reliabilities were good to excellent.InterpretationReductions in independent joint control measured in infancy are a hallmark of eventual diagnosis of spastic CP, and influence gross motor function later in childhood (with or without a diagnosis of CP).What this paper adds

Early brain injury causing spastic cerebral palsy results in fewer independent joint movements in infants.
Baby Observational Selective Control AppRaisal (BabyOSCAR) score at 3 months depends on limbs affected by early brain injury.
BabyOSCAR scores at 3 months correlate with Gross Motor Function Classification System level at ≥2 years.
BabyOSCAR has excellent interrater reliability.
BabyOSCAR, scored with a 1‐minute video recording, has good to excellent test–retest reliability.
The ABCG8 polymorphism increases the risk of gallbladder cancer in the general population and gallstones in obese patients from Poland
Authors: Krupa Lukasz , Kalinowski Piotr , Ligocka Joanna , Dauer Marc , Jankowski Krzysztof , Gozdowska Jolanta , Kruk Beata , Milkiewicz Piotr , Zieniewicz Krzysztof , Krawczyk Marek , Weber Susanne N. , Lammert Frank , Krawczyk Marcin 
Published: April 2024

AbstractBackgroundGallstone disease (GD) is common but remains asymptomatic in most cases. However, gallstones can lead to complications like choledocholithiasis or gallbladder cancer. In this study, we analyse the common genetic risk factor for GD, the p.D19H variant in the sterol transporter ABCG8, in Polish patients with gallstones and gallbladder cancer.MethodsThree adult cohorts were prospectively recruited: 65 patients with gallbladder cancer, 170 obese individuals scheduled for bariatric surgery and 72 patients who underwent endoscopic retrograde cholangiopancreatography due to recurrent choledocholithiasis. The control cohort consisted of 172 gallstone‐free adults. The ABCG8 p.D19H (rs11887534) polymorphism was genotyped using TaqMan assays.ResultsThe minor allele frequency (MAF) of the ABCG8 p.D19H polymorphism was significantly (p = .02) higher among cases with either gallstones or gallbladder cancer (MAF = 8.4%) as compared to controls (MAF = 4.0%). The highest frequency of the risk allele was detected in patients with gallbladder cancer (18.5%) and obese patients with GD (17.5%), followed by individuals with choledocholithiasis (13.9%). Notably, the p.19H variant was associated with an increased risk of developing gallbladder cancer (OR 2.76, 95% CI 1.16–6.54, p = .01) and an increased risk of GD in obese individuals scheduled for bariatric surgery (OR = 2.70, 95% CI 1.05–6.49, p = .03), but did not significantly affect the risk of choledocholithiasis.ConclusionsThe ABCG8 p.D19H common risk variant increases the risk of developing gallbladder cancer in Central Europeans and enhances the risk of gallstones in the obese. Carriers of the p.D19H variant might benefit from personalized preventive strategies, particularly regarding gallbladder cancer.
Rapid assessment of beech leaf disease in Fagus sylvatica buds
Authors: Wolf Emily , Vieira Paulo 
Published: April 2024

AbstractThe European beech (Fagus sylvatica) is threatened by the foliar nematode Litylenchus crenatae subsp. mccannii (Lcm), the causal agent of beech leaf disease (BLD). Thus far, the majority of studies regarding BLD have focused on American beech (F. grandifolia). To better determine the impact of Lcm in buds of European beech, a total of 54 buds were collected from naturally symptomatic trees. Here, we characterized for the first time the bud scale morphology of two different cultivars of F. sylvatica infected with Lcm. Detailed observations of asymptomatic and symptomatic bud scales provided insight into the physical changes and arrangements of cells in the bud scale, shedding light on the dynamic processes occurring during Lcm infection. In addition, we evaluated the suitability of using the bud scale morphology for the early detection of BLD and Lcm in naturally infected buds. The distinct cellular arrangement of symptomatic bud scales cells (i.e., asymmetric pattern of enlarged cells) provides a rapid and visual, user‐friendly methodology to prematurely diagnose BLD symptoms within the buds, as well as the detection of associated nematodes.
Teaching mathematics in innovative learning environments—The entangled tensions between the learning environment and pedagogy
Authors: Alakoski Riikka , Laine Anu , Hannula Markku S. 
Published: April 2024

AbstractNew school buildings are often designed for flexible innovative learning environments (ILEs) to support learning future skills better than before. However, little is known about the relationship between environment and pedagogy. This article examines the relationship between the environment and pedagogy from the perspective of primary school teachers in the context of teaching mathematics. We interviewed 26 teachers from 10 Finnish ILEs and did a thematic analysis. The relationship between the environment and pedagogy forms a complex network of entangled tensions between teacher's inner space, community's social space and physical space. When the tensions between these spaces were resolved in a positive way, ILEs enabled pedagogy that diversified mathematics education, improved student cohesion and teachers' well‐being at work. However, the ILEs' transformation process often appears to be left unfinished, leading to unsuccessful resolution of tensions. Further, our findings highlight the importance of four‐dimensional environmental competence in exploiting the affordances enabled by ILE.
Post‐transplant‐cyclophosphamide and short‐term Everolimus as graft‐versus‐host‐prophylaxis in patients with relapsed/refractory lymphoma and myeloma—Final results of the phase II OCTET‐EVER trial
Authors: Richardson Tim , Scheid Christof , Herling Marco , Frenzel Lukas P. , Herling Carmen , Aguilar Marta Rebecca Cruz , Theurich Sebastian , Hallek Michael , Holtick Udo 
Published: April 2024

AbstractBackgroundConditioning regimens and the choice of immunosuppression have substantial impact on immune reconstitution after allogeneic hematopoietic stem cell transplantation (aHSCT). The pivotal mechanism to maintain remission is the induction of the graft‐versus‐tumor effect. Relapse as well as graft versus host disease remain common. Classic immunosuppressive strategies implementing calcineurin inhibitors (CNI) have significant toxicities, hamper the immune recovery, and reduce the anti‐cancer immune response.MethodsWe designed a phase II clinical trial for patients with relapsed and refractory lymphoid malignancies undergoing aHSCT using a CNI‐free approach consisting of post‐transplant cyclophosphamide (PTCy) and short‐term Everolimus after reduced‐intensity conditioning and matched peripheral blood stem cell transplantation. The results of the 19 planned patients are presented. Primary endpoint is the cumulative incidence and severity of acute GvHD.ResultsOverall incidence of acute GvHD was 53% with no grade III or IV. Cumulative incidence of NRM at 1, 2, and 4 years was 11%, 11%, and 16%, respectively, with a median follow‐up of 43 months. Cumulative incidence of relapse was 32%, 32%, and 42% at 1, 2, and 4 years after transplant, respectively. Four out of six early relapses were multiple myeloma patients. Overall survival was 79%, 74%, and 62% at 1, 2, and 4 years. GvHD‐relapse‐free‐survival was 47% after 3 years.ConclusionsUsing PTCy and short‐term Everolimus is safe with low rates of aGvHD and no severe aGvHD or cGvHD translating into a low rate of non‐relapse mortality. Our results in this difficult to treat patient population are encouraging and warrant further studies.
Benefit corporation certification and financial performance: Capital structure matters
Authors: Asma‐Arikan Özlem , Tosun Onur Kemal 
Published: April 2024

AbstractWe are examining the impact of benefit corporation certification on the profitability of UK companies, taking into account their capital structure. We contribute to the literature that scrutinizes the financial ramifications of Benefit Corporation Certification. Analyzing UK Certified Benefit Corporations (CBCs) and their noncertified counterparts using a difference‐in‐differences analysis, we find that the performance of CBCs with a capital structure heavily weighted towards debt declines in comparison to non‐CBCs, using Return on Assets as a measure of financial performance. Conversely, the performance of CBCs with a capital structure primarily composed of equity is comparable to that of non‐CBCs.
A dilated convolution‐based method with time series fine tuning for data‐driven crack length estimation
Authors: Gao Jiaxin , Hu Wenbo , Han Qinan , Chen Yuntian , Hong Richang , Shi Huiji 
Published: April 2024

AbstractThis paper presents a novel crack size estimation method based on dilated convolution and time series fine tuning using in‐situ Lamb wave. The contributions of this proposed method are twofold: (1) a dilated convolution‐based neural network which is an effective representation learning methods with larger receptive fields for periodic signals and (2) a crack length adjustment approach based on previous estimations with a time series fine tuning method. The time series fine tuning method utilizes the monotonicity of the crack length with respect to time. A new evaluation metric has been adopted, which considers prediction errors, time errors, and monotonicity errors. The proposed method outperforms the previous feature extraction‐based methods with or without time series fine tuning in this new evaluation metric.
Angling bait consumption and stable isotope niche of two cyprinids in different lake fisheries
Authors: Imbert Alexis , Beisel Jean‐Nicolas , Boulêtreau Stéphanie , Cucherousset Julien 
Published: April 2024

Abstract

Terrestrial subsidies are important for freshwater ecosystems and, in lakes supporting recreational fisheries, angling baits can represent an important allochthonous input. This resource can directly contribute to fish diet but its consumption may be influenced by fish body size and the type of angling baits used in different fisheries. In this study, we evaluated angling baits consumption by two common cyprinid species, Cyprinus carpio and Rutilus rutilus, in three fishery types (specialised carp, specialised roach, and put‐and‐take fisheries).

We used stable isotope analyses (δ13C and δ15N) of cyprinids, their natural prey and different angling baits in 16 gravel pit lakes located in south‐western France, including four lakes without angling.

Angling baits were significantly δ13C‐enriched and δ15N‐depleted compared to natural prey. Overall, angling bait consumption was highly variable between individuals. For C. carpio, angling bait consumption averaged 30.5% (±17.0 SD) and was higher in specialised carp fisheries (40.0% ± 16.7 SD) than in put‐and‐take fisheries (15.9% ± 9.0 SD) and was not related to body size. For R. rutilus, angling bait consumption averaged 41.3% (±15.7 SD), did not differ significantly among fishery types, but increased with body size. The niche width of C. carpio was six times larger in specialised carp fisheries than in lakes without angling. For R. rutilus, niche width was two times larger in specialised carp and put‐and‐take fisheries compared to lakes without angling and specialised roach fisheries.

These results indicate that angling bait subsidies represent a novel and substantial resource opportunity for fishes in angling lakes, with trophic consequences for the targeted species through increase of their stable isotope niche size. These impacts are partly influenced by the type of angling baits used by anglers and the characteristics of the fisheries, suggesting the need for improved quantification of the temporal dynamics of this type of subsidy to better understand its consequences on freshwater fish and recipient ecosystems.
Predictors of Respiratory Syncytial Virus, Influenza Virus, and Human Metapneumovirus Carriage in Children Under 5 Years With WHO‐Defined Fast‐Breathing Pneumonia in Pakistan
Authors: Nisar Muhammad Imran , Kerai Salima , Shahid Shahira , Qazi Muhammad Farrukh , Rehman Sarah , Aziz Fatima , Jehan Fyezah 
Published: April 2024

ABSTRACTBackgroundPneumonia is a leading cause of morbidity and mortality in children < 5 years. We describe nasopharyngeal carriage of respiratory syncytial virus (RSV), human metapneumovirus (hMPV), and influenza virus among children with fast‐breathing pneumonia in Karachi, Pakistan.MethodsWe performed a cross‐sectional analysis of nasopharyngeal swabs from children aged 2–59 months with fast‐breathing pneumonia, enrolled in the randomized trial of amoxicillin versus placebo for fast‐breathing pneumonia (RETAPP) (NCT02372461) from 2014 to 2016. Swabs were collected using WHO standardized methods, processed at the Aga Khan University, Pakistan. Viral detection was performed using LUMINEX xTAG respiratory viral panel assay and logistic regression identified clinical and sociodemographic predictors.FindingsOf the 1000 children tested, 92.2% (n = 922) were positive for viral carriage. RSV, hMPV, and influenza virus were detected in 59 (6.4%), 56 (6.1%), and 58 (6.3%) children and co‐infections in three samples (two RSV‐hMPV and one influenza‐hMPV). RSV carriage was common in infants (56%), we observed a higher occurrence of fever in children with hMPV and influenza virus (80% and 88%, respectively) and fast breathing in RSV (80%) carriage. RSV carriage was positively associated with a history of fast/difficulty breathing (aOR: 1.96, 95% CI 1.02–3.76) and low oxygen saturation (aOR: 2.52, 95% CI 1.32–4.82), hMPV carriage was positively associated with a complete vaccination status (aOR: 2.22, 95% CI 1.23–4.00) and body temperature ≥ 37.5°C (aOR: 2.34, 95% CI 1.35–4.04) whereas influenza viral carriage was associated with body temperature ≥ 37.5°C (aOR: 4.48, 95% CI 2.53–7.93).ConclusionWe observed a high nasopharyngeal viral carriage among children with WHO‐defined fast‐breathing pneumonia in Pakistan. Fever, difficulty in breathing, hypoxia and vaccination status are important clinical predictors for viral nonsevere community‐acquired pneumonia.
The role of orthobiologics in chronic wound healing
Authors: Domingues Rafael Barnabé , von Rautenfeld Marita , Kavalco Caroline Mayara , Caliari Carolina , Dellagiustina Celso , da Fonseca Lucas Furtado , Costa Fabio Ramos , da Cruz Silva Reis Andreza , Santos Gabriel Silva , Azzini Gabriel , de Faria André Pinto Lemos , Santos Napoliane , Pires Luyddy , Huber Stephany Cares , Mahmood Ansar , Dallo Ignacio , Everts Peter , Lana José Fábio 
Published: April 2024

AbstractChronic wounds, characterized by prolonged healing processes, pose a significant medical challenge with multifaceted aetiologies, including local and systemic factors. Here, it explores the complex pathogenesis of chronic wounds, emphasizing the disruption in the normal phases of wound healing, particularly the inflammatory phase, leading to an imbalance in extracellular matrix (ECM) dynamics and persistent inflammation. Senescent cell populations further contribute to impaired wound healing in chronic lesions. Traditional medical management focuses on addressing underlying causes, but many chronic wounds resist to conventional treatments, necessitating innovative approaches. Recent attention has turned to autologous orthobiologics, such as platelet‐rich plasma (PRP), platelet‐rich fibrin (PRF) and mesenchymal stem cells (MSCs), as potential regenerative interventions. These biologically derived materials, including bone marrow aspirate/concentrate (BMA/BMAC) and adipose tissue‐derived stem cells (ADSCs), exhibit promising cytokine content and regenerative potential. MSCs, in particular, have emerged as key players in wound healing, influencing inflammation and promoting tissue regeneration. This paper reviews relevant scientific literature regarding basic science and brings real‐world evidence regarding the use of orthobiologics in the treatment of chronic wounds, irrespective of aetiology. The discussion highlights the regenerative properties of PRP, PRF, BMA, BMAC and SVF, showcasing their potential to enhance wound healing. Despite advancements, further research is essential to elucidate the specific roles of each orthobiologic and determine optimal applications for different wound types. The conclusion underscores the evolving landscape in chronic wound management, with a call for more comprehensive studies to refine treatment strategies and maximize the benefits of regenerative medicine.
Adaptive designs in dermatology clinical trials: Current status and future perspectives
Authors: Potvin D. , D'Angelo P. , Bennett S. , Jankicevic J. , Bissonnette R. 
Published: April 2024

AbstractCurrent drug development strategies present many challenges that can impede drug approval by regulatory agencies. Alternative study models, such as adaptive trial designs, have recently sparked interest, as they provide a flexible and more efficient approach in conducting clinical trials. Adaptive trial designs offer several potential benefits over traditional randomized controlled trials, which include decrease in costs, reduced clinical development time and limiting exposure of patients to potentially ineffective treatments allowing completion of studies with fewer patients. This article explores the current use of adaptive trial designs in non‐oncologic skin diseases and highlights the most common types of adaptive designs used in the field. We also review the operational challenges and statistical considerations associated with such designs and propose clinical development strategies to successfully implement adaptive designs. The article also proposes instances where adaptive trial designs are particularly beneficial, and other situations where they may not be very useful.