bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Influence of Wind Forcing on the Chesapeake Bay Buoyant Coastal Current*
Authors: Lentz Steven J. , Largier John 
Published: August 2006

Abstract
Observations of the buoyant coastal current that flows southward from Chesapeake Bay are used to describe how the thickness, width, and propagation speed vary in response to changes in the along-shelf wind stress. Three basic regimes were observed depending on the strength of the wind. For weak wind stresses (from −0.02 to 0.02 Pa), the buoyant coastal current was relatively thin, the front slope was not steep, and the width was variable (1–20 km). For moderate downwelling (southward) wind stresses (0.02–0.07 Pa), wind-driven cross-shelf advection steepened the front, causing the plume to narrow and thicken. For stronger downwelling wind stresses (greater than 0.07 Pa), vertical mixing dominated, bulk Richardson numbers were approximately 0.25, isopycnals were nearly vertical, and the plume front widened but the plume width did not change. Plume thickness and width were normalized by the theoretical plume scales in the absence of wind forcing. Normalized plume thickness increased linearly from 1 to 2 as downwelling wind stresses increased from 0 to 0.2 Pa. Normalized plume widths were approximately 1 for downwelling wind stresses from 0.02 to 0.2 Pa. The observed along-shelf propagation speed of the plume was roughly equal to the sum of the theoretical propagation speed and the wind-driven along-shelf flow.
Observed Variability of Ocean Wave Stokes Drift, and the Eulerian Response to Passing Groups
Authors: Smith Jerome A. 
Published: August 2006

Abstract
Waves and currents interact via exchanges of mass and momentum. The mass and momentum fluxes associated with surface waves are closely linked to their Stokes drift. Both the variability of the Stokes drift and the corresponding response of the underlying flow are important in a wide range of contexts. Three methods are developed and implemented to evaluate Stokes drift from a recently gathered oceanic dataset, involving surface velocities measured continually over an area 1.5 km in radius by 45°. The estimated Stokes drift varies significantly, in line with the occurrence of compact wave groups, resulting in highly intermittent maxima. One method also provides currents at a fixed level (Eulerian velocities). It is found that Eulerian counterflows occur that completely cancel the Stokes drift variations at the surface. Thus, the estimated Lagrangian surface flow has no discernable mean response to wave group passage. This response is larger than anticipated and is hard to reconcile with current theory.
Wave–Current Interactions in Finite Depth
Authors: Smith Jerome A. 
Published: August 2006

Abstract
The energy, momentum, and mass-flux exchanges between surface waves and underlying Eulerian mean flows are considered, and terms in addition to the classical wave “radiation stress” are identified. The formulation is made in terms of the vertically integrated flow. The various terms are identified with other analyses and interpreted in terms of physical mechanisms, permitting reasonable estimates of the associated depth dependencies. One term is identified with the integrated “CL vortex force” implemented, for example, in simulations of Langmuir circulation. However, as illustrated with a simple example of steady refraction across a shear zone, other terms of the same order can significantly alter the results. The classic example of long waves forced by short-wave groups is also revisited. In this case, an apparent singularity arising in shallow water is countered by finite-amplitude dispersion corrections, these being formally of the same order as the forced long-wave response, and becoming significant or dominant as shallow water is approached.
Gravitational Potential Energy Balance for the Thermal Circulation in a Model Ocean
Authors: Huang Rui Xin , Jin Xingze 
Published: August 2006

Abstract
The gravitational potential energy balance of the thermal circulation in a simple rectangular model basin is diagnosed from numerical experiments based on a mass-conserving oceanic general circulation model. The vertical mixing coefficient is assumed to be a given constant. The model ocean is heated/cooled from the upper surface or bottom, and the equation of state is linear or nonlinear. Although the circulation patterns obtained from these cases look rather similar, the energetics of the circulation may be very different. For cases of differential heating from the bottom with a nonlinear equation of state, the circulation is driven by mechanical energy generated by heating from the bottom. On the other hand, circulation for three other cases is driven by external mechanical energy, which is implicitly provided by tidal dissipation and wind stress. The major balance of gravitational energy in this model ocean is between the source of energy due to vertical mixing and the conversion from kinetic energy at low latitudes and the sink of energy due to convection adjustment and conversion to kinetic energy at high latitudes.
Two Different Aperiodic Phases of Wind-Driven Ocean Circulation in a Double-Gyre, Two-Layer Shallow-Water Model
Authors: Matsuura Tomonori , Fujita Mitsutaka 
Published: August 2006

Abstract
A two-layer shallow-water model is used to investigate the transition of wind-driven double-gyre circulation from laminar flow to turbulence as the Reynolds number (Re) is systematically increased. Two distinctly different phases of turbulent double-gyre patterns and energy trajectories are exhibited before and after at Re = 95: deterministic and fully developed turbulent circulations. In the former phase, the inertial subgyres vary between an asymmetric solution and an antisymmetric solution and the double-gyre circulations reach the aperiodic solution mainly due to their barotropic instability. An integrated kinetic energy in the lower layer is slight and the generated mesoscale eddies are confined in the upper layer. The power spectrum of energies integrated over the whole domain at Re = 70 has peaks at the interannual periods (4–7 yr) and the interdecadal period (10–20 yr). The loops of the attractors take on one cycle at those periods and display the blue-sky catastrophe. At Re = 95, the double-gyre circulation reaches a metastable state and the attracters obtained from the three energies form a topological manifold. In the latter, as Re increases, the double-gyre varies from a metastable state to a chaotic state because of the barotropic instability of the eastward jet and the baroclinic instability of recirculation retrograde flow, and the eastward jet meanders significantly with interdecadal variability. The generated eddies cascade to the red side of the power spectrum as expected in the geostrophic turbulence. The main results in the simulation may indicate essential mechanisms for the appearance of multiple states of the Kuroshio and for low-frequency variations in the midlatitude ocean.
Tornadoes in Environments with Small Helicity and/or High LCL Heights
Authors: Davies Jonathan M. 
Published: August 2006

Abstract
Recent studies have suggested that supercell tornado environments are usually associated with large 0–1-km storm-relative helicity (SRH) and relatively low lifting condensation levels (LCL heights). However, occasional tornadoes of significance occur in environments having characteristics that appear less supportive of supercell tornadoes, including small SRH values and/or relatively high LCL heights. Such tornadoes, whether associated with supercell or nonsupercell processes (more precisely termed mesocyclone and nonmesocyclone processes), present a challenge for forecasters. This empirical study uses a database of soundings derived from the Rapid Update Cycle model to examine thermodynamic characteristics of F1 and greater intensity tornado events associated with small SRH and/or high LCL heights. Results strongly suggest that many such tornado events are associated with steep lapse rates in the lowest few kilometers above ground. The low level of free convection heights, small convective inhibition, and sizable convective available potential energy below 3 km were also found to be of possible importance. These thermodynamic characteristics combined would likely reduce resistance to upward accelerations, potentially enhancing ascent for low-level parcels entering thunderstorm updrafts and, hence, low-level stretching. From prior research, if preexisting boundaries were available to provide surface vertical vorticity for stretching, such thermodynamic characteristics could be an important component of tornado events that involve nonmesocyclone processes. These same thermodynamic characteristics may also offer clues for the investigation of mesocyclone tornado events that do not fit well with accepted tornado forecasting parameters from prior studies.
The Sensitivity of Numerical Forecasts to Convective Parameterization: A Case Study of the 17 February 2004 East Coast Cyclone
Authors: Mahoney Kelly M. , Lackmann Gary M. 
Published: August 2006

Abstract
The sensitivity of numerical model forecasts of coastal cyclogenesis and frontogenesis to the choice of model cumulus parameterization (CP) scheme is examined for the 17 February 2004 southeastern U.S. winter weather event. This event featured a complex synoptic and mesoscale environment, as the presence of cold-air damming, a developing coastal surface cyclone, and an upper-level trough combined to present a daunting winter weather forecast scenario. The operational forecast challenge was further complicated by erratic numerical model predictions. The most poignant area of disagreement between model runs was the treatment of a coastal cyclone and an associated coastal front, features that would affect the location and timing of precipitation and influence the precipitation type. At the time of the event, it was hypothesized that the Betts–Miller–Janjić (BMJ) CP scheme was dictating the location and intensity of the initial coastal cyclone center in operational Eta Model forecasts. For this reason, forecasts for this case were rerun with the workstation Eta Model using the Kain–Fritsch (KF) CP scheme to further examine the sensitivity to this parameterization choice. Results confirm that the model CP scheme played a major role in the forecast for this case, affecting the quantitative precipitation forecast as well as the strength, location, and structure of coastal cyclogenesis and coastal frontogenesis. The Eta Model forecast using the KF CP scheme produced a relatively uniform distribution of convective precipitation oriented along the axis of an inverted trough and strong coastal front. In contrast, the BMJ forecasts resulted in a weaker coastal front and the development of multiple distinct closed cyclonic circulations in association with more localized convective precipitation centers. An additional BMJ forecast in which the shallow mixing component of the scheme was disabled bore a closer semblance to the KF forecasts relative to the original BMJ forecast. Suggestions are provided to facilitate the identification of CP-driven cyclones using standard operational model output parameters.
Impact of Four-Dimensional Variational Data Assimilation of Atmospheric Motion Vectors on Tropical Cyclone Track Forecasts
Authors: Wang Dongliang , Liang Xudong , Duan Yihong , Chan Johnny C. L. 
Published: August 2006

Abstract
The fifth-generation Pennsylvania State University–National Center for Atmospheric Research nonhydrostatic Mesoscale Model is employed to evaluate the impact of the Geostationary Meteorological Satellite-5 water vapor and infrared atmospheric motion vectors (AMVs), incorporated with the four-dimensional variational (4DVAR) data assimilation technique, on tropical cyclone (TC) track predictions. Twenty-two cases from eight different TCs over the western North Pacific in 2002 have been examined. The 4DVAR assimilation of these satellite-derived wind observations leads to appreciable improvements in the track forecasts, with average reductions in track error of ∼5% at 12 h, 12% at 24 h, 10% at 36 h, and 7% at 48 h. Preliminary results suggest that the improvement depends on the quantity of the AMV data available for assimilation.
Late Aramaic: The Literary and Linguistic Context of the Zohar
Authors: Rapoport-Albert Ada , Kwasman Theodore 
Published: August 2006

AbstractThis article introduces a new research project focusing on the Aramaic language of the Zohar—the most influential work in the literary canon of the Jewish mystical tradition. The Zohar is generally assumed by scholars to have been written in Spain during the final decades of the thirteenth century, although traditional kabbalists and Orthodox Jews believe that it was authored by its main protagonist, Rabbi Shimon bar Yohai, in second-century Palestine. While not disputing the late medieval provenance of the work, this article challenges the standard scholarly opinion whereby the Aramaic in which it was written was an artificially manufactured idiom, drawing its vocabulary, grammar and syntax indiscriminately from a variety of 'genuine' Aramaic sources. Part I of this study demonstrates that some of the most distinctive 'flaws' of zoharic Aramaic are attested in a wide range of much earlier Aramaic sources. Part II, which will be published separately, as a sequel, concerns the related question of the Palestinian setting of the Zohar.
On the Etymology of Some Enigmatic Words in North-Eastern Neo-Aramaic
Authors: Mutzafi Hezy 
Published: August 2006

AbstractThe present article seeks to clarify the etymologies of several selected North-Eastern Neo-Aramaic (NENA) lexical oddities of unknown or uncertain origin. All lexical items in question are proven to be of Aramaic provenance, yet mere recourse to Classical Aramaic is inadequate for uncovering the origins of these puzzling words due to far-reaching diachronic changes that have distanced them from their precursors. Missing links, based on interdialectal studies within NENA, are therefore crucial for securing well-founded etyma for these lexical enigmas. In addition to adducing missing links found in cognate dialects, each etymological discussion specifies the diachronic processes involved in the development of the lexical item under consideration.
Differences in the frequency and function of HHV8-specific CD8 T cells between asymptomatic HHV8 infection and Kaposi sarcoma
Authors: Lambert Marion , Gannagé Monique , Karras Alexandre , Abel Michal , Legendre Christophe , Kerob Delphine , Agbalika Felix , Girard Pierre-Marie , Lebbe Celeste , Caillat-Zucman Sophie 
Published: August 2006

AbstractIt is unclear how the immune response controls human herpesvirus 8 (HHV8; also known as Kaposi sarcoma–associated herpesvirus [KSHV]) replication and thereby prevents Kaposi sarcoma (KS). We compared CD8 T-cell responses to HHV8 latent (K12) and lytic (glycoprotein B, ORF6, ORF61, and ORF65) antigens in patients who spontaneously controlled the infection and in patients with posttransplantation, AIDS-related, or classical KS. We found that anti-HHV8 responses were frequent, diverse, and strongly differentiated toward an effector phenotype in patients who controlled the infection. Conversely, HHV8-specific CD8 cells were very rare in patients who progressed to KS, and were not recruited to the tumoral tissue, as visualized by in situ tetramer staining of KS biopsies. Last, HHV8-specific CD8 T cells were observed in a seronegative recipient of an HHV8infected graft who remained persistently aviremic and antibody negative, suggesting that specific cytotoxic T lymphocytes (CTLs) may provide protection from persistent HHV8 infection. These results support the crucial role of cellular immune responses in controlling HHV8 replication, in preventing malignancies in latently infected subjects, and in conferring genuine resistance to persistent infection. They may also have important implications for the design of prophylactic and therapeutic HHV8 vaccines, and for adoptive immunotherapy of KS.
Most human thymic and peripheral-blood CD4+CD25+ regulatory T cells express 2 T-cell receptors
Authors: Tuovinen Heli , Salminen Jukka T. , Arstila T. Petteri 
Published: August 2006

AbstractLack of allelic exclusion in the T-cell receptor (TCR) α locus gives rise to 2 different TCRs in 10% to 30% of all mature T cells, but the significance of such dual specificity remains controversial. Here we show that human CD4+CD25+ regulatory T (Treg) cells express 2 distinct Vα chains and thus 2 TCRs at least 3 times as often as other T cells. Extrapolating from flow cytometric analysis using Vα2-, Vα12-, and Vα24-specific monoclonal antibodies (mAbs), we estimated that between 50% and 99% of the CD25+ Treg cells were dual specific, as compared with about 20% of their CD25– counterparts. Moreover, both TCRs were equally capable of transmitting signals upon ligation. Cells with 2 TCRs also expressed more FOXP3, the Treg-cell lineage specification factor, than cells with a single TCR. Our findings suggest that expression of 2 TCRs favors differentiation to the Treg-cell lineage in humans and raise the question of the potential functional consequences of dual specificity.
A transgenic zebrafish model of neutrophilic inflammation
Authors: Renshaw Stephen A. , Loynes Catherine A. , Trushell Daniel M.I. , Elworthy Stone , Ingham Philip W. , Whyte Moira K.B. 
Published: August 2006

AbstractWe have established an in vivo model for genetic analysis of the inflammatory response by generating a transgenic zebrafish line that expresses GFP under the neutrophil-specific myeloperoxidase promoter. We show that inflammation is induced after transection of the tail of zebrafish larvae and that this inflammation subsequently resolves over a similar time course to mammalian systems. Quantitative data can be generated from this model by counting of fluorescent cells or by digital image analysis. In addition, we show that the resolution of experimentally induced inflammation can be inhibited by the addition of a pancaspase inhibitor, zVD.fmk, demonstrating that experimental manipulation of the resolution of inflammation is possible in this model.
Increased blood pressure in adult offspring of families with Balkan Endemic Nephropathy: a prospective study
Authors: Dimitrov Plamen S , Simeonov Valeri A , Tsolova Svetlana D , Bonev Angel G , Georgieva Rossitza B , Karmaus Wilfried J 
Published: August 2006

Abstract

Background
Previous studies have linked smaller kidney dimensions to increased blood pressure. However, patients with Balkan Endemic Nephropathy (BEN), whose kidneys shrink during the course of the disease, do not manifest increased blood pressure. The authors evaluated the relationship between kidney cortex width, kidney length, and blood pressure in the offspring of BEN patients and controls.

Methods
102 offspring of BEN patients and 99 control offspring of non-BEN hospital patients in the Vratza District, Bulgaria, were enrolled in a prospective study and examined twice (2003/04 and 2004/05). Kidney dimensions were determined using ultrasound, blood pressure was measured, and medical information was collected. The parental disease of BEN was categorized into three groups: mother, father, or both parents. Repeated measurements were analyzed with mixed regression models.

Results
In all participants, a decrease in minimal kidney cortex width of 1 mm was related to an increase in systolic blood pressure of 1.4 mm Hg (p = 0.005). There was no association between kidney length and blood pressure. A maternal history of BEN was associated with an increase in systolic blood pressure of 6.7 mm Hg (p = 0.03); paternal BEN, +3.2 mm Hg (p = 0.35); or both parents affected, +9.9 mm Hg (p = 0.002). There was a similar relation of kidney cortex width and parental history of BEN with pulse pressure; however, no association with diastolic blood pressure was found.

Conclusion
In BEN and control offspring, a smaller kidney cortex width predisposed to higher blood pressure. Unexpectedly, a maternal history of BEN was associated with average increased systolic blood pressure in offspring.
Differential DNA methylation profiles in gynecological cancers and correlation with clinico-pathological data
Authors: Yang Hui-Juan , Liu Vincent WS , Wang Yue , Tsang Percy CK , Ngan Hextan YS 
Published: August 2006

Abstract

Background
Epigenetic gene silencing is one of the major causes of carcinogenesis. Its widespread occurrence in cancer genome could inactivate many cellular pathways including DNA repair, cell cycle control, apoptosis, cell adherence, and detoxification. The abnormal promoter methylation might be a potential molecular marker for cancer management.

Methods
For rapid identification of potential targets for aberrant methylation in gynecological cancers, methylation status of the CpG islands of 34 genes was determined using pooled DNA approach and methylation-specific PCR. Pooled DNA mixture from each cancer type (50 cervical cancers, 50 endometrial cancers and 50 ovarian cancers) was made to form three test samples. The corresponding normal DNA from the patients of each cancer type was also pooled to form the other three control samples. Methylated alleles detected in tumors, but not in normal controls, were indicative of aberrant methylation in tumors. Having identified potential markers, frequencies of methylation were further analyzed in individual samples. Markers identified are used to correlate with clinico-pathological data of tumors using χ2 or Fisher's exact test.

Results

APC and p16 were hypermethylated across the three cancers. MINT31 and PTEN were hypermethylated in cervical and ovarian cancers. Specific methylation was found in cervical cancer (including CDH1, DAPK, MGMT and MINT2), endometrial cancer (CASP8, CDH13, hMLH1 and p73), and ovarian cancer (BRCA1, p14, p15, RIZ1 and TMS1). The frequencies of occurrence of hypermethylation in 4 candidate genes in individual samples of each cancer type (DAPK, MGMT, p16 and PTEN in 127 cervical cancers; APC, CDH13, hMLH1 and p16 in 60 endometrial cancers; and BRCA1, p14, p16 and PTEN in 49 ovarian cancers) were examined for further confirmation. Incidence varied among different genes and in different cancer types ranging from the lowest 8.2% (PTEN in ovarian cancer) to the highest 56.7% (DAPK in cervical cancer). Aberrant methylation for some genes (BRCA1, DAPK, hMLH1, MGMT, p14, p16, and PTEN) was also associated with clinico-pathological data.

Conclusion
Thus, differential methylation profiles occur in the three types of gynecologic cancer. Detection of methylation for critical loci is potentially useful as epigenetic markers in tumor classification. More studies using a much larger sample size are needed to define the potential role of DNA methylation as marker for cancer management.