bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reining in Rebellion: The Decline of Political Violence in South America, 1830–1929
Authors: Madrid Raúl L. , Schenoni Luis L. 
Published: March 2024

Abstract
During the nineteenth century, South America was plagued by internal rebellions that destabilized the region's economies and political systems. At the beginning of the twentieth century, however, levels of political violence throughout the region declined dramatically. Existing scholarship has paid surprisingly little attention to this historic transformation, in part because comprehensive data on revolts have been lacking. Historical narratives and an analysis of a comprehensive new dataset on all revolts in South America from 1830 to 1929 show that the decline in revolts stemmed in large part from the expansion and professionalization of the region's militaries, which were driven by the export boom and the threat of interstate conflict. Nevertheless, not all types of rebellions declined precipitously during this period, as an original typology of revolts shows. Although the strengthening of the region's armed forces discouraged revolts by non-state actors, it did not significantly reduce rebellions from within the state apparatus, such as military coups.
Assimilation of Radar Reflectivity via a Full-Hydrometeor Assimilation Scheme Based on the WSM6 Microphysics Scheme in WRF 4D-Var
Authors: Yang Sen , Li Deqin , Huang Xiang-yu , Liu Zhiquan , Pan Xiao , Duan Yunxia 
Published: March 2024

Abstract
The microphysical parameterization scheme employed in four-dimensional variational data assimilation (4D-Var) plays an important role in the assimilation of humidity and cloud-sensitive observations. In this study, a newly developed full-hydrometeor assimilation scheme, integrating warm-rain and cold-cloud processes, has been implemented in the Weather Research and Forecasting (WRF) 4D-Var system. This scheme is based on the WRF single-moment 6-class microphysics scheme (WSM6). Its primary objective is to directly assimilate radar reflectivity observations, with the goal of evaluating its effects on model initialization and subsequent forecasting performance. Four assimilation experiments were conducted to assess the performance of the full-hydrometeor assimilation scheme against the warm-rain assimilation scheme. These experiments also investigated reflectivity assimilation using both indirect and direct methods. We found that the nonlinearity of the radar operator in the two direct reflectivity assimilation experiments requires more iterations for cost function reduction than in the indirect assimilation method. The hydrometeor fields were reasonably analyzed using the full-hydrometeor assimilation scheme, particularly improving the simulation of ice-phase hydrometeors and reflectivity above the melting layer. The assimilation of radar reflectivity led to improvements in short-term (0–3 h) precipitation forecasting with the full-hydrometeor assimilation scheme. Assimilation experiments across multiple case studies reaffirmed that assimilating radar reflectivity observations with the full-hydrometeor assimilation scheme accelerated model spinup and yielded enhancements in 0–3-h total accumulate precipitation forecasts for a range of precipitation thresholds.
Structural and nonlinear J-integral fracture toughness for nanoclay toughened ternary HDPE/LDPE-g-MA/ABS blend nanocomposites
Authors: Albdiry Mushtaq 
Published: March 2024

High-density polyethylene (HDPE) has a higher strength-to-density ratio and stiffness but a low branching degree for the packed linear chains that restrict the ability to bond and resist cracking. This study conducts the role of inserting rigid nanoclay (NC) and soft acrylonitrile butadiene styrene (ABS) on the structural, nonlinear fracture toughness and crack resistance of a ternary HDPE/low-density polyethylene-grafted maleic anhydrite (LDPE-g-MA)/ABS blend. Varying additions of 1, 3, 5, and 7 % NC and 5, 10, 15 wt. % ABS were inserted into neat HDPE and HDPE90/LDPE-g-MA10. All materials were hand-mixed before feeding into a single screw extruder and directly melt-blended twice to achieve a good dispersion of nanofiller in the matrix. The structural characteristics and the fracture surfaces of NC/HDPE/LDPE-g-MA and NC/HDPE/LDPE-g-MA/ABS were investigated by TEM, XRD, SEM, and FTIR spectra. Tensile strength and the critical dissipated energy (JIc) determined by quasi-static J-integral fracture mechanic revealed a higher absorbing fracture energy of 75 KJ/m2 for the binary and 85 KJ/m2 for the ternary nanocomposites. The synergistic percolated role of the NC particles and ABS copolymer in front of the crack tip region hinders crack growth for the presence of micro-void coalescence and massive shear-yielding toughening mechanisms.
An Analysis of Questions from Teachers' Online Groups: Turning the Lens Back to Teacher Education
Authors: Friedrich Daniel , Shanahan James 
Published: March 2024

Background or Context: During the first months of the COVID pandemic, teachers were forced to move to online instruction without the appropriate resources. They resorted to social media to gather expertise and ideas. This study is grounded in an analysis of the questions posed by K–12 teachers on popular Facebook groups. Purpose, Objective, Research Question, or Focus of Study: The authors argue that a close analysis of what K–12 educators are asking and wondering about in online teacher groups at a moment in which much of what they know and trust has been disrupted can be generative as a novel feedback loop to engage in conversations about some common practices in teacher education. Specifically, they ask: How can an analysis of questions posed by educators on public Facebook groups in the early pandemic enter into a productive conversation with teacher education programs beyond the specificities of that context? Research Design: The study performs a thematic analysis based on categories that were inductively coded from 752 questions posed between March and June 2020 by educators in the three most popular public Facebook groups dedicated exclusively to K–12 teaching during the pandemic. The goal is to consider the underlying assumptions and ideas embedded in the questions being asked in these groups, and to place them within the context of the authors’ political understandings of the role of teacher education. Conclusions or Recommendations: Four themes emerged from the analysis: an expanding notion of community, tensions in the understandings of “context,” new positionings of expertise, and a questioning of what counts as legitimate schooling. The themes led to a need for teacher education programs to always consider their students’ professional identities as collectively constructed and to find ways to disrupt universal models of the mind. The authors also invite programs to rethink the location of expertise by taking into account the practices that young teachers are already engaged in when seeking professional knowledge. This opening could potentially lead to perhaps the hardest thing to do within teacher education programs: to provide the conditions to reimagine schooling.
Implementing Longitudinal Wellbeing Interventions and Evaluation Among Midwestern Healthcare Workers During COVID-19
Authors: Lally Robin M. , Schmidt Rachael , Kupzyk Kevin , Wengel Steven P. , Cordts Katrina Poppert , Mills Adam C. , Richards Sarah E. 
Published: March 2024

Background: The impact of the COVID-19 pandemic on the mental health of healthcare workers throughout the world has been reported, but most studies have been cross-sectional and excluded the Midwestern U.S. healthcare workforce. Objective: This study aimed to longitudinally assess the psychological wellbeing and wellness strategies used by a Midwestern academic health system’s workforce at multiple points throughout waves of the COVID-19 pandemic to inform ongoing implementation of appropriate wellness activities. Methods: An anonymous REDCap survey linked within our team-developed wellness education was posted in the employee online newsletter in April (T1), July (T2), October 2020 (T3), and May 2021 (T4). Surveys were open to all employees (approx. 9000) for approximately 12 days at each time point. Anxiety, depressive symptoms, stress, self-efficacy, and self-care activities were assessed. Following each data collection, team members discussed findings and planned wellness education implementation. Results: Response ranged from n = 731 (T1) to n = 172 (T4). Moderate to severe stress was reported by 29.5% ( n = 203) of respondents at T1 and 34.0% ( n = 108) at T2. At T3, all psychological symptoms significantly increased ( p < .001) as COVID-19 surged, with 48.5% ( n = 141) of respondents reporting moderate to severe stress. At T4, stress significantly declined ( p < .001). Exercise was the most frequently reported coping strategy. Conclusions: Mental health symptoms reported by a Midwestern healthcare workforce increased during surges of COVID-19 hospitalizations. Individuals in non-patient contact roles experienced symptom levels similar to and at times with greater severity than healthcare personnel with patient contact roles.
Management of cancer treatment–induced bone loss in patients with breast and hormone sensitive prostate cancer: AIOM survey
Authors: Valsecchi Anna Amela , Fusco Vittorio , Di Maio Massimo , Santini Daniele , Tucci Marcello , De Giorgi Ugo , Dionisio Rossana , Vignani Francesca , Cinieri Saverio 
Published: March 2024

Purpose: Cancer treatment–induced bone loss is a side effect of hormonal therapy that can severely affect patients' quality of life. The aim of this survey was to obtain an updated picture of management of bone health in patients with breast cancer undergoing adjuvant hormonal therapy and in patients with hormone sensitive prostate cancer according to Italian oncologists. Methods: Our survey was made up of 21 multiple-choice questions: the first part dealt with the respondents’ characteristics, while the second with management of bone health in the described setting. An invitation to complete the survey was sent by e-mail to 2336 oncologists, members of Italian Association of Medical Oncology, in October 2022. Results: Overall, 121 (5.2%) Italian oncologists completed the survey. In most cases (57%) the oncologist personally took charge of the management of bone health in patients at risk for cancer treatment–induced bone loss. At the beginning of hormonal therapy, most respondents reported to require bone health diagnostic exams, such as dual-energy X-ray absorptiometry (89%), repeated with different timing. Main reported reasons (not mutually exclusive) for prescribing antiresorptive drugs were modifying fracture risk (87%), densitometry values (75%) or prognosis (34%). Answers about the management of antiresorptive therapy were heterogeneous. Conclusion: A heterogeneous approach on the management of cancer treatment–induced bone loss in Italy arises from this survey. This scenario highlights the need for a major consensus of the Italian scientific community on the diagnostic and therapeutic approach of cancer treatment–induced bone loss and for a greater awareness of this topic among Italian oncologists.
The impact of short-term postoperative face-up position on unintentional retinal displacement after pars plana vitrectomy for rhegmatogenous retinal detachment
Authors: Lopez Juan Manuel , Iros Mariano , Francone Anibal , Mehanna Carl-Joe , Crincoli Emanuele , Bernard Agnes Glacet , Miere Alexandra , Souied Eric H. 
Published: March 2024

Objective To assess the effectiveness and safety of a rigorous short-term supine position in preventing inadvertent retinal displacement after pars plana vitrectomy (PPV) with gas tamponade for rhegmatogenous retinal detachment (RRD). Methods We conducted a retrospective observational analysis of a case series at two ophthalmological surgical centers. We included eyes diagnosed with macula-off RRD that maintained a strict face-up position for three hours immediately after PPV with intraoperative perfluorocarbon liquid (PFCL) and 20% sulfur hexafluoride (SF6) tamponade. Fundus autofluorescence (FAF) imaging was performed at one month post-operatively to identify unintentional retinal displacement through the detection of retinal vessel prints (RVPs) on FAF imaging using an ultrawide-field (UWF) imaging system. Results A total of 29 eyes with macula-off RRD were included in the study. The average age of the participants was 59.62 years. RRD involved one quadrant in two eyes, two quadrants in fourteen eyes, three quadrants in seven eyes, and four quadrants in six eyes. UWF-FAF imaging at one month follow-up after complete reattachment of the retina revealed RVPs in seven out of the 29 eyes (24.13%), with a mean displacement of 0.22 mm. In every case the displacement occurred downward. Conclusion Our results suggest that adhering to a strict face-up position for three hours after PPV with PFCL and gas tamponade for macula-off RRD may lead to a low frequency and severity of inadvertent post-operative retinal displacement.
Which factors are associated with a successful outcome following total hip arthroplasty in patients with early radiographic osteoarthritis?
Authors: Sharrock Martin , Board Tim N 
Published: March 2024

Background: It is unclear which factors are associated with a successful total hip arthroplasty (THA) in patients with early radiographic osteoarthritis (OA). Methods: 70 patients with early OA (Kellgren and Lawrence [KL] grades 0–2) who underwent THA were compared with 200 patients with advanced OA (KL grades 3–4). Outcomes were Oxford Hip Scores (OHS), EQ-5D and EQ-VAS scores; compared preoperatively with 1 year postoperatively. We investigated which clinical and radiographic (plain x-ray, CT, MRI) features predicted successful THA (postoperative OHS ⩾42). Results: The early OA group were significantly younger (61 vs. 66 years; [ p  = 0.0035). There were no significant differences in BMI, ASA grade or gender. After adjusting for confounders, the advanced OA group had a significantly greater percentage of possible change (PoPC) in OHS (75.8% vs. 50.4%; p  < 0.0001) and improvement in EQ-5D (0.151 vs. 0.002; p  < 0.0001). There were no significant differences in complication, revision or readmission rates. In the early OA group, 16/70 (22.9%) patients had a ‘successful’ THA. Patients who had a ‘successful’ THA were significantly more likely to have subchondral cysts on CT/MRI (91.7% vs. 57.7%; p  = 0.0362). The presence of cysts on CT/MRI was associated with a significantly greater PoPC in OHS (61.6% vs. 38.2%; p  = 0.0353). The combination of cysts and joint space width <1 mm was associated with a PoPC of 68%. Conclusions: THA in patients with early OA (KL grades 0–2) on plain radiographs should be indicated with caution. We advocate preoperative cross-sectional imaging in these patients. In the absence of cysts on CT/MRI, a THA seems unlikely to provide a satisfactory outcome.
All-cause and cause-specific mortality by spirometric pattern and sex – a population-based cohort study
Authors: Backman Helena , Sawalha Sami , Nilsson Ulf , Hedman Linnea , Stridsman Caroline , Vanfleteren Lowie E. G. W. , Nwaru Bright I. , Stenfors Nikolai , Rönmark Eva , Lindberg Anne 
Published: March 2024

Background: Chronic airway obstruction (CAO) and restrictive spirometry pattern (RSP) are associated with mortality, but sex-specific patterns of all-cause and specific causes of death have hardly been evaluated. Objectives: To study the possible sex-dependent differences of all-cause mortality and patterns of cause-specific mortality among men and women with CAO and RSP, respectively, to that of normal lung function (NLF). Design: Population-based prospective cohort study. Methods: Individuals with CAO [FEV1/vital capacity (VC) < 0.70], RSP [FEV1/VC ⩾ 0.70 and forced vital capacity (FVC) < 80% predicted] and NLF (FEV1/VC ⩾ 0.70 and FVC ⩾ 80% predicted) were identified within the Obstructive Lung Disease in Northern Sweden (OLIN) studies in 2002–2004. Mortality data were collected through April 2016, totally covering 19,000 patient-years. Cox regression and Fine–Gray regression accounting for competing risks were utilized to estimate hazard ratios (HRs) with 95% confidence intervals (CIs) adjusted for age, body mass index, sex, smoking habits and pack-years. Results: The adjusted hazard for all-cause mortality was higher in CAO and RSP than in NLF (HR, 95% CI; 1.69, 1.31–2.02 and 1.24, 1.06–1.71), and the higher hazards were driven by males. CAO had a higher hazard of respiratory and cardiovascular death than NLF (2.68, 1.05–6.82 and 1.40, 1.04–1.90). The hazard of respiratory death was significant in women (3.41, 1.05–11.07) while the hazard of cardiovascular death was significant in men (1.49, 1.01–2.22). In RSP, the higher hazard for respiratory death remained after adjustment (2.68, 1.05–6.82) but not for cardiovascular death (1.11, 0.74–1.66), with a similar pattern in both sexes. Conclusion: The higher hazard for all-cause mortality in CAO and RSP than in NLF was male driven. CAO was associated with respiratory death in women and cardiovascular death in men, while RSP is associated with respiratory death, similarly in both sexes.
The effects of treatment with pimavanserin on activities of daily living in patients with Parkinson’s disease psychosis: a 16-week, single-arm, open-label study
Authors: Evidente Virgilio G. H. , DeKarske Daryl , Coate Bruce , Abler Victor 
Published: March 2024

Background: More than half of patients with Parkinson’s disease will experience psychosis symptoms in the form of hallucinations or delusions at some point over the course of their disease. These symptoms can significantly impact patients’ health-related quality of life, cognitive abilities, and activities of daily living (ADLs) and function. Clinical assessment of how psychosis impacts these measures is crucial; however, few studies have assessed this sufficiently, in part due to a lack of appropriate scales for comprehensively assessing function. Objective: The objective was to assess how symptoms of Parkinson’s disease psychosis (PDP) impact ADLs and function, cognitive function, and health-related quality of life. Design: To address this unmet need, we utilized a modified version of the Functional Status Questionnaire (mFSQ) to measure the impact of psychosis on ADLs and function in patients with PDP treated with pimavanserin, a US Food and Drug Administration-approved medication to treat hallucinations and delusions associated with PDP. Methods: Eligible patients entered a 16-week, single-arm, open-label study of oral pimavanserin (34 mg) taken once daily. The primary endpoint was change from baseline to Week 16 on the mFSQ. Secondary endpoints included the Movement Disorders Society–modified Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) I and II; Schwab and England ADL; Clinical Global Impression–Severity of Illness (CGI-S), Clinical Global Impression–Improvement (CGI-I), and Patient Global Impression–Improvement (PGI-I), and were also measured as change from baseline to Week 16 using mixed-effects model for repeated measures (MMRM) and least-squares mean (LSM). Results: Our results in a proof-of-concept, 16-week, open-label clinical study in 29 patients demonstrated that an improvement in psychosis symptoms following treatment with pimavanserin was associated with improvements in multiple measures of ADLs and function. Notably, a significant improvement was found on the primary endpoint, change from baseline to Week 16 in mFSQ score [LSM [SE] 14.0 [2.50], n = 17; 95% CI (8.8, 19.3); p < 0.0001]. Conclusion: These findings highlight the potential for improvement in function with improvement of psychosis symptoms in patients with PDP and suggest that the mFSQ may be a measurement tool to evaluate the level of improvement in function. Trial registration: ClinicalTrials.gov Identifier: NCT04292223.
Short-term versus usual-term antibiotic treatment for uncomplicated Staphylococcus aureus bacteremia: a systematic review and meta-analysis
Authors: Grillo Perez Santiago , Diaz-Brochero Candida , Garzon Herazo Javier Ricardo , Muñoz Velandia Oscar Mauricio 
Published: March 2024

Introduction: Uncomplicated Staphylococcus aureus bacteremia remains a leading cause of morbidity and mortality in hospitalized patients. Current guidelines recommend a minimum of 14 days of treatment. Objective: To evaluate the efficacy and safety of short versus usual antibiotic therapy in adults with uncomplicated S. aureus bacteremia (SAB). Methods: We developed a search strategy to identify systematic review and meta-analysis of non-randomized studies (NRS), comparing short versus usual or long antibiotic regimens for uncomplicated SAB in MEDLINE, Embase, and the Cochrane Register up to June 2023. The risk of bias was assessed using the ROBINS I tool. The meta-analysis was performed using Review Manager software with a random effect model. Results: Six NRS with a total of 1700 patients were included. No significant differences were found when comparing short versus prolonged antibiotic therapy as defined by the authors for 90-day mortality [odds ratio (OR): 1.09; 95% confidence interval (CI): 0.82–1.46, p: 0.55; I2 = 0%] or 90-day recurrence or relapse of bacteremia [OR: 0.72; 95% CI: 0.31–1.68, p: 0.45; I2 = 26%]. Sensitivity analysis showed similar results when comparing a predefined duration of <14 days versus ⩾14 days and when excluding the only study with a high risk of bias. Conclusion: Shorter-duration regimens could be considered as an alternative option for uncomplicated SAB in low-risk cases. However, based on a small number of studies with significant methodological limitations and risk of bias, the benefits and harms of shorter regimens should be analyzed with caution. Randomized clinical trials are needed to determine the best approach regarding the optimal duration of therapy.
Use of Tibial Cortical Autograft for the Osteotomy Site in Medial Opening-Wedge High Tibial Osteotomy
Authors: Kesemenli Cumhur Cevdet , Demiroz Serdar , Memisoglu Kaya , Erdemir Cengiz , Yonga Ömer , Temez Faruk , Karadeniz Emre 
Published: March 2024

Background: Medial opening-wedge high tibial osteotomy (OWHTO) is a useful treatment option in patients with medial compartment osteoarthritis. Typically, the osteotomy site is filled with material such as autologous bone graft, allograft, or synthetic bone substitute. However, all these options have disadvantages. Purpose/Hypothesis: The purpose of this study was to describe tibial cortical autograft as an alternative to conventional graft options. It was hypothesized that the tibial rectangular cortical bone that is removed from the proximal medial cortical surface of the distal tibial fragment longitudinally could be a reliable option for recovery of the gap in the osteotomy area. Study Design: Cohort study; Level of evidence, 3. Methods: A total of 520 patients with medial compartment osteoarthritis who underwent OWHTO between June 2009 and March 2019 were retrospectively analyzed. Patients were divided into 3 groups according to the graft material used to fill the osteotomy site: allograft in group A, iliac crest autograft in group B, and tibial autograft in group C. Bone union, evaluated by radiographs performed at 2 weeks, 4 weeks, 2 months, 3 months, 6 months, and 1 year postoperatively, was defined as occurring when at least 50% of the gap site was bridged with callus. Clinical assessment was performed using the International Knee Documentation Committee (IKDC) and Lysholm scores. Results: Included were 122 patients: 40 patients in group A, 42 patients in group B, and 40 patients in group C. The mean correction was 13.87°± 3.58° in group A, 12.33°± 3.92° in group B, and 14.10°± 2.99° in group C. The mean time for radiological bone union was 6.95 ± 1.40 months in group A, 4.48 ± 1.02 months in group B, and 5.07 ± 1.70 months in group C. Patients in all groups had similar IKDC and Lysholm scores at the final follow-up. Conclusion: This is the first report of this specific procedure in the literature. All clinical and radiological findings showed that use of tibial cortical autograft was an efficient method in patients undergoing OWHTO.