bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlates of loneliness and dissatisfaction following SARS pandemic lockdown: Child and parent perspective
Authors: SHARMA RAJNI , GHAI BABITA , SAINI LOKESH , JAIN ADITI , KUMAR KRISHAN , BRAR RUBINDERJIT SINGH , SINGH SHUBH MOHAN , SURI VIKAS , YADAV JAIVINDER , MOHINDRA RITIN , GUPTA NITIN 
Published: March 2024

Background
Studying loneliness among children is important because it causes much social pain and is considered to be a risk factor for many mental and physical problems.

Methods
We did an online survey between July and September 2020 among students and their parents from a cluster of government and private schools chosen from north, south, east and west of Chandigarh. The survey consisted of child and parent versions of the Loneliness and Social Dissatisfaction Questionnaire, Parent–Child Relationship (PCR) Questionnaire and Conflict Behaviour Questionnaire SF. Parental distress was assessed using the Depression, Anxiety and Stress Scale-21.

Results
The majority of children and parent participants reported high loneliness and dissatisfaction among children. A significant positive association was found between children and parent reported loneliness and dissatisfaction, and between child reported PCR and parent perception of PCR. A child’s appraisal of her loneliness had a significant negative association with depression among parents. Parent’s perception of child loneliness and dissatisfaction was negatively associated with PCR and parental anxiety. High loner boys reported poor quality of relationship and more conflicts with their parents than girls. Children who share cordial relations with their parents had fewer conflicts and also scored low on loneliness.

Conclusion
These results suggest that the issue of loneliness and dissatisfaction among children has attained epidemic proportions in the Covid-19 era, and active interventions are needed to safeguard the mental health of children. Our study emphasizes the need to plan guidance strategies with a joint effort of schools and families to strengthen within family relations of children.
Experience with exon 45 skipping therapy in patients with Duchenne muscular dystrophy
Authors: Артемьева С.Б. , Белоусова Е.Д. , Влодавец Д.В. , Кузенкова Л.М. , Михайлова С.В. , Подклетнова Т.В. , Попович С.Г. , Увакина Е.В. , Усачева Е.Л. 
Published: March 2024

Прогрессирующая мышечная дистрофия Дюшенна (ПМД Дюшенна) является наиболее распространенным нервно-мышечным заболеванием в мире. ПМД Дюшенна относится к группе так называемых дистрофинопатий, связанных с мутациями в гене DMD, наследуется по Х-сцепленному рецессивному типу и обусловлена либо полным отсутствием белка дистрофина, либо его дефектным синтезом. В настоящее время появилось несколько патогенетических лекарственных препаратов, направленных на восстановление синтеза белка дистрофина. Одним из них является антисмысловой олигонуклеотид касимерсен, работающий по технологии экзон-скиппинга 45 экзона. В статье представлен первый опыт применения препарата касимерсен у 6 пациентов из России, причем пациенты значимо отличались друг от друга по функциональному статусу и имеющимся осложнениям основного заболевания. У всех пациентов применение касимерсена было безопасным, не было выявлено никаких нежелательных явлений, связанных с применением препарата. А у одного из пациентов, находящегося на ранней амбулаторной стадии болезни, которому патогенетическая терапия была инициирована в возрасте 7 лет, констатирована выраженная положительная динамика в виде прироста дистанции на 140 метров по результатам 6-минутного теста ходьбы и увеличения на 10 баллов по шкале «Северная Звезда».
Duchenne muscular dystrophy (DMD) is the most common neuromuscular disease in the world. DMD belongs to the group of so-called dystrophinopathies associated with mutations in the DMD gene, is inherited in an X-linked recessive manner and is caused by either the complete absence of the dystrophin protein or its defective synthesis. Currently, several pathogenetic drugs have appeared aimed at restoring the synthesis of the dystrophin protein. One of them is the antisense oligonucleotide casimersen, which works using exon skipping technology of exon 45 in DMD gene. The article presents the first experience of using the drug casimersen in 6 patients from Russia, and the patients differed significantly from each other in functional status and existing complications of the underlying disease. In all patients, the use of casimersen was safe, and no adverse events associated with the use of the drug were identified. And in one of the patients, who was at an early outpatient stage of the disease, for whom pathogenetic therapy was initiated at the age of 7 years, pronounced positive dynamics were noted in the form of an increase in distance by 140 meters according to the results of a 6-minute walking test and an increase of 10 points on the «North Star».
CROSS BORDER COMMUNITY EMPOWERMENT THROUGH SELLING PRICE LITERACY: EVIDENCE FROM INDONESIA–TIMOR LESTE CROSS BORDERS
Authors: Brito Manuel , Freitas João Câncio , Aleixo Afonso , Sonbay Yolinda Yanti , Timuneno Antonius Yohanes Wiliam , Manehat Beatrix Yunarti , Betu Kristina Wada , Dawu Leopold Melkiano Trian 
Published: March 2024

Purpose: This study aims to carry out an empowerment cross.border community to increase the understanding and ability of border economic actors to determine appropriate and competitive selling prices based on the costs incurred.

Theoretical Framework: The empowerment, training, and financial literacy theory are adapted in this article to explain cross-border residents' economic transactions.

Design/Methodology/Approaches: The method used in this study is a combination of qualitative and quantitative, which compiles and analyzes dan combines both qualitative and quantitative information.

Finding: The results of the activity show that participants' understanding and skills increased after carrying out this activity, in which they appropriately determined the selling price by first calculating the production costs.

Research Practical & Social Implication: In this study, the cross-border community realizes the benefits of financial knowledge to enhance business development and sustainability for their well-being.

Originality/Value: The findings of the research can potentially contribute to the development of business environments and policies to facilitate and enhance cross-border trade potential.
PUBLIC POLICIES TO REDUCE SWITCHING COSTS LINKED TO MANDATORY ACCESS TO CERTAIN ELEMENTS OF THE POSTAL NETWORK IN THE EU AND THE EFFECTS OF THE RETENTION COSTS
Authors: Pateiro-Rodríguez Carlos , Prado-Domínguez Antonio Javier , Pateiro-López Carlos , Martín-Bermúdez Federico 
Published: March 2024

Purpose: Our objective is to examine the switching costs that exist in the European postal service, where an ambitious process of opening up to competition has been carried out since 1997, as well as the different types of retention costs.

Theoretical Framework: The theoretical framework is determined by the sectoral regulatory framework regarding the liberalization of services of general economic interest in the EU, the experience of postal operators in recent decades and the changes experienced in the demand for postal services in the current context of profound technological change in the field of communication.

Design/Methodology/Approach: This research work is carried out through a systematic review of the relevant specialized literature, the study of the policy decisions adopted in the EU, the changes in the strategies of postal operators and the rigorous analysis of the evolution of the demand of the postal services in a context of rapid and profound change.

Finding: Inadequate regulation of the access to some elements of postal infrastructure or services within the scope of the universal postal service, such as the postcode system, address database, post office boxes, delivery boxes, re-direction and retour to sender service, can generate switching costs and thus limiting competition, with negative effects on the consumer surplus and social welfare. Standardization and access to these elements may be regulated separately

Research, Practical & Social Implications: This article proposes solutions to the technical functions of coordination between operators. Our proposals are in line with sectoral directives aimed at strengthening competition in the long term in the postal market.

Originality/Value: A correct classification of the change costs applied to the liberalized postal service is made. Likewise, a classification of retention costs. We must underline the progress that our proposals represent to reduce the costs of switching to elements of the postal network whose access is mandatory.
DESENVOLVIMENTO LOCAL-REGIONAL NO NORDESTE BRASILEIRO: UM ESTUDO SITUACIONAL DO ARRANJO PRODUTIVO LOCAL DE CAPRINOVINOCULTURA DE PERNAMBUCO
Authors: Pimentel Neto José Geraldo , Oliveira Heitor Salvador de , Silveira Keilha Correia da 
Published: March 2024

O presente trabalho tem como foco compreender as dificuldades do não desenvolvimento do arranjo produtivo local (APL) da caprinovinocultura no Estado de Pernambuco. Para tanto, foram desenvolvidas visitas técnicas em diversas instituições que atuam no desenvolvimento do setor na região do APL, além de realizar uma análise mais detalhada das dificuldades desse respectivo setor produtivo no Estado de Pernambuco. A falta de estrutura e produção com forte vinculação rural e práticas laborais arcaicas gerando dificuldades em pontos estratégicos da atividade econômica. A falta de equipamento, como um matadouro, e de gestão integrada de políticas públicas direcionadas para diversas áreas do setor econômico, tais como capacitação aos produtores, são indicadores que dificultam a consolidação do APL da caprinovinocultura no Estado. Além dessas visitas, foram realizadas entrevistas qualitativas para o entendimento do APL, os pontos trabalhados foram a problemáticas, visões e propostas para melhorar a cadeia produtiva. Das respostas, foram indicados os principais gargalos responsáveis pelo não desenvolvimento do setor junto ao território, pois essa situação é a que defini as características de um Arranjo Produtivo Local. Alguns resultados identificados para o APL caprovinicultura em Pernambuco foram: (a) problemas no manejo e produção, (b) problemas na convivência com a seca, (c) instalações apropriadas para a produção e manejo, (d) falta de conhecimento técnico do produtor, (e) problemas com a posse da terra, entre outros.
ANÁLISE DO USO E COBERTURA DA TERRA DA BACIA HIDROGRÁFICA DO RIO PIMENTA, ILHA DO MARANHÃO – MA, BRASIL
Authors: Gomes de Lima Cristina , Vale Barros França Danyella , Quésia Duarte Silva  , Gonçalves Santana Ricardo 
Published: March 2024

O conhecimento sobre as dinâmicas de uso e cobertura da terra ganham cada vez mais força diante da necessidade de sustentação das questões ambientais ligadas às relações sociedade/natureza. Partindo desse pressuposto, objetivou-se neste trabalho analisar o uso e cobertura da terra da bacia hidrográfica do rio Pimenta no ano de 2023 e sua relação com os impactos gerados na área de estudo. Para alcançar o objetivo proposto realizou-se procedimentos como: levantamento bibliográfico, trabalhos de campo e mapeamento em gabinete. A partir disto diagnosticou-se que as morfologias da bacia em questão têm sido alteradas pela urbanização e que os canais de primeira ordem têm sido alterados, prejudicando a dinâmica hídrica da região. Os padrões atuais de uso são áreas urbanas de alta e média densidade e mata secundária fragmentada. Salienta-se também que diversos canais fluviais de primeira ordem desapareceram em virtude da pressão urbana na localidade
THE EFFECT OF SULFUR – CONTAINING COMPOUNDS ON THE STABILITY OF DIESEL FUELS
Authors: A Zuhdan Fathoni. , D Batts. B. , F Sprecher. R. , G Veloski. 
Published: March 2024

A high-resolution low-voltage mass spectrometric study has been carried out on the sulfur-containing fractions of fresh diesel fuel and on samples aged at 43°C in borosilicate bootles (ASTM D 4625 test) for periods of 6.5, 13, 19,5 and 26 weeks, and at 80°C for periods of 0.5, 1, 1.5, 2, 3, and 4 weeks. Homologous series of benze-and di benzothiophenes are the principal sulphur-containing compounds were detected. The concentrations of all species present with aging were monitored and the role of each compound in the gum-forming process assessed.
GASOLINE SPECIFICATIONS IN THE ASEAN COUNTRIES
Authors: Jasjfi E. 
Published: March 2024

Gasoline is one of the most important petroleum products which is directly used by a large section of the general public. Countries of the Southeast Asia have been cooperating closely in many fields, including the petroleum industry. In view of the facts, it would be of prime interest to examine and compare the gasoline specifications in the ASEAN countries. This paper presents the results of the study, based on the official standard specifications in force in five ASEAN countries. The similarities and differences are emphasized, as well as their significance.
Pemanfaatan Learning System Dalam Penggunaan Media Pembelajaran Online Masa Pandemi Covid-19
Authors: Wati Risna , Astuti Astuti , Sulaeman Sulaeman 
Published: March 2024

Penelitian ini bertujuan untuk mengetahui pemanfaatan Learning Manajement System dalam penggunaan media pembelajaran online masa pandemi di Mts As’Adiyah Itterung Kecamatan Tellusiattinge Kabupaten Bone, mengetahui hambatan dan solusi dalam Penggunaan Media Pembelajaran online masa pandemi. Jenis penelitian yang digunakan penulis adalah kualitatif kemudian dipaparkan secara deskriptif dengan menggunakan pendekatan penelitian pedagogic, psikologis dan sosiologis. Adapun lokasi penelitian adalah MTs As’Adiyah Itterung Desa Itterung Kecamatan Tellusiattinge Kabupaten Bone. Datayang digunakan dalam penelitian ini adalah aata primer dan data sekunder. Sumber data primer yang menjadi sasaran penelitian yaitu kepala madrasah, guru dan siswa. Adapun sumber data sekunder yaitu dokumen terkait, dan bahan-bahan pustaka yang relevan dengan masalah penelitian. Analisis data dilakukan melalui reduksi data, penyajian data dan penarikan kesimpulan. Hasil penelitianmenunjukka npembelajaran online selama pandemi terjadiperubahan proses pembelajaran dari pembelajaran tatapmuka di kelas menjadi pembelajaran online atau daring dengan memanfaatkan Learning Manajement System. Media Pembelajaran Online Masa Pandemi yaitu media pembelajaran yang digunakan pendidik monoton dan membuat para peserta didik merasa jenuh atau bosan dan belum interaktif. Keterbatasan handphone yang dimiliki orang tua peserta didik dan kesulitan akses internet. Solusi dalam mengatasi hambatan yaitu dengan menggunakan media pembelajaran yang dapat dijangkau oleh pendidik dan peserta didik.
La sustitución, en las plataformas de delivery, de los falsos autónomos por empresas contratistas. Modelo bendecido, por ahora, en las primeras sentencias dictadas
Authors: Lacomba Pérez Fco. Ramón 
Published: March 2024

- Precario mío, yo te bendigo en el nombre de la contrata, el algoritmo y la cesión de mano de obra
+ Loada sea la App
RETROSPECTIVE COHORT STUDY TO EVALUATE THE CLINICAL EFFICACY OF REMDESIVIR IN THE TREATMENT OF PATIENTS WITH SEVERE COVID-19
Authors: Yakovenko O. K. 
Published: March 2024

The purpose of the study is to evaluate the clinical effectiveness of remdesivir in hospitalized patients with severe COVD-19 during complex treatment according to the National Protocol of the Ministry of Health of Ukraine. Materials and methods. We used to the data of a retrospective cohort study in adult patients (≥ 18 years old) with severe COVID-19, who were admitted to the infectious diseases department No. 2 of the Volyn Regional Clinical Hospital from December 2020 to May 2021. The statistical analysis included a group of patients who received Remdesivir (n = 98) and a control group of patients who did not receive Remdesivir (n = 190), which was modified. Results. It was found that 98 patients (n = 98) with severe COVID-19 who received Remdesivir at a course dose of 600 mg in 91.8% of cases (n = 90) recovered, the average age of those who recovered was 56.8 ± 2.56 years. On average, the beginning of the infusion of Remdesivir upon admission to the infectious diseases hospital occurred on the 9th day from the first day of the disease. In 8.2 % (n = 8), Remdesivir did not help patients with severe COVID-19 who died in intensive care, the average age of the deceased was 68.5 ± 5.83 years. During the study, it was found that the use of Remdesivir on average from the 9th day of illness at a course dose of 600 mg did not additionally affect the rate of restoration of saturation in patients with severe COVID-19 at the time of discharge from the hospital, and as an additive drug did not additionally affect on the reduction of CRP in the complex therapy with Dexamethasone of severe COVID-19, and also did not affect the use and/or reduction of the use of antibacterial drugs in patients with severe COVID-19. The use of Remdesivir did not significantly affect the decrease in the number of days of hospitalization, however, it significantly influenced the time of normalization of body temperature and, on average, this decrease was 1.7 ± 0.6 days in patients with severe COVID-19 compared with the control group without antiviral drug. It was found that Remdesivir in a course dose of 600 mg does not negatively affect creatinine levels and does not lead to renal dysfunction in patients with severe COVID-19. Despite the fact that 91.8 % of patients who received Remdesivir recovered, there was no statistically significant reduction in mortality (р > 0,05) in the age group of patients aged 56 to 79 years with severe COVID-19 when using Redmesivir in the second week of illness (median onset of antiviral therapy is 9 days), therefore, Remdesivir must be administered prior to the onset of severe COVID-19 with a hyperinflammatory condition. Key words: coronavirus disease, severe COVID-19, remdesivir, retrospective cohort study.
Study the Optical and Morphological Properties of (PMMA/PS/Al2O3) Nanocomposites Before and After Exposed to Argon Plasma
Authors: Mohammad Nayef Fatima , Rabee Bahaa H. 
Published: March 2024

This study aimed to investigate the alterations in the structural and optical properties of Poly-methyl-methacrylate (PMMA) and Polystyrene (PS) through the utilization of different weight percentages of Aluminum oxide (Al2O3) nanoparticles (2%, 4%, 6%, and 8%) by weight. The optical microscope images indicate that the distribution of nanoparticles in the blend was uniform, resulting in a continuous network within the polymer matrix. The field emission scanning electron microscope revealed that there was a connection between the interface that connects the polymer matrix and the additive. The optical properties before and after the exposure to Ar plasma exhibited that the absorbance, absorption coefficient, refractive index, extinction coefficient, dielectric constant (real, imaginary) and optical conductivity of (PMMA/PS/Al2O3) nanocomposites increased with the increasing of the concentrations of the Al2O3. The transmittance and the energy gap for indirect transition (allowed, forbidden) decreased with the increasing concentrations of Al2O3 nanoparticles. The optical properties after irradiation are seen to have high values compared with those before the irradiation which is attributed to the increased charge carriers and the occurrence of some bonds breaking. Finally, the results indicated that the (PMMA/PS/ Al2O3) nanostructures can be considered as promising materials for optoelectronics nanodevices.
MODELLING AND SOLVING COURSE SCHEDULING PROBLEMS (CASE STUDY: MATHEMATICS STUDY PROGRAM, INSTITUT TEKNOLOGI SUMATERA)
Authors: Mustika Mira , Wamiliana  , Setiawan Roni 
Published: March 2024

Every educational institution has a standard process for scheduling courses. In scheduling, there are a lot of constraints that must be fulfilled, including hard and soft constraints. Hard constraints are constraints that must be met and cannot be disregarded; a lecturer, for instance, is limited to teaching one course in one room at a time. Soft constraints, on the other hand, are a type of restriction that can be broken, but breaks are minimized to the greatest extent possible. The aim of this research is to produce an optimal lecture schedule and to provide alternative solutions. The case study taken is the even semester at Institut Teknologi Sumatera (ITERA) Mathematics Study Program. The problem is modelled using Goal Programming and solved using LINGO. The result shows that the scheduling can fulfill every requirement.
PENGARUH KEPUASAN KERJA DAN MOTIVASI KERJA TERHADAP KOMITMEN ORGANISASI PARA LULUSAN POLMAN BANDUNG DI PERUSAHAAN MANUFAKTUR
Authors: Sadikin Supriyadi , Ariyani Emma Dwi , Muzakki Mochammad Raja Aldien , Muhammad Achmad , Waluyo Gamawan Ananto 
Published: March 2024

Organizational commitment merupakan faktor penting dalam keberhasilan sebuah perusahaan, karena tingkat komitmen yang tinggi dari pegawai akan lebih cenderung mempertahankan keanggotaan serta berkontribusi secara aktif dalam organisasi.Adanya 2 variabel yang mempengaruhi organizational commitment yaitu kepuasan kerja dan motivasi kerja. Data para lulusan Polman Bandung pada 1 -2 tahun bekerja diperkirakan pindah atau tidak menetap pada 1 perusahaan ini bisa dipengaruhi pada Kepuasan dan Motivasi kerja yang ada pada lulusan Polman Bandung.
Berdasarkan analisis diperoleh hasil bahwa kepuasan kerja dan motivasi kerja berpengaruh positif dan signifikan terhadap organizational commitment para lulusan Polman Bandung yang berjumlah 1000 orang dalam 3 tahun terakhir yang bekerja di perusahaan manufaktur. Hasil penelitian menggambarkan kepuasan dan motivasi kerja yang semakin meningkat, maka semakin tinggi pula tingkat organizational commitment para lulusan Polman Bandung di perusahaan manufaktur.
Kesimpulannya, kepuasan dan motivasi kerja memiliki peran yang penting didalam membentuk organizational commitment para lulusan Polman Bandung yang bekerja di perusahaan manufaktur. Dengan memfokuskan faktor terhadap kepuasan dan motovasi kerja, perusahaan dapat meningkatkan loyalitas dan kontribusi karyawan, yang pada gilirannya akan berdampak positif pada keberhasilan organisasi secara keseluruhan.
ANALISIS REAKSI PASAR SAHAM MENGGUNAKAN ABNORMAL RETURN DAN TRADING VOLUME ACTIVITY TERHADAP PENGUMUMAN LAYOFF PERUSAHAAN
Authors: Rooroh Ryo Junior , Dewi Vera Intanie 
Published: March 2024

Penelitian ini bertujuan untuk mengetahui reaksi pasar saham terhadap pengumuman layoff yang dilakukan oleh perusahaan go publik di Indonesia di tahun 2020-2022. Penelitian ini menggunakan metodologi event study sebagai alat untuk menganalisis data sampel pada 13 perusahaan yang terdaftar di Bursa Efek Indonesia. Estimasi pasar diukur menggunakan abnormal return dan trading volume activity. Sampel ditentukan menggunakan teknik purposive sampling. Penelitian ini menggunakan jenis data sekunder dan pengambilan data melalui studi dokumen. Jangka waktu analisis antara 5 hari sebelum pengumuman layoff hingga 5 hari setelah tanggal pengumuman layoff. Hasil penelitian menunjukkan bahwa dua dari 13 emiten menunjukkan perbedaan antara abnormal return (AR) sebelum dan sesudah pengumuman layoff, yaitu ALTO dan HERO yang menunjukkan abnormal return yang negatif sesudah adanya pengumuman layoff, sedangkan pada berdasarkan trading volume activity (TVA), dua dari 13 emiten yang menunjukkan perbedaan sebelum dan sesudah pengumuman layoff, yaitu emiten HMSP yang menunjukkan TVA lebih kecil setelah pengumuman layoff dan GIAA yang menunjukkan TVA lebih besar setelah pengumuman layoff.