bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Orient of One’s Own: Music and Islamic Modernism in the Late Ottoman Empire
Authors: Olley Jacob 
Published: April 2024

AbstractDuring the late nineteenth and early twentieth centuries, Muslim intellectuals sought to articulate new forms of Islamic thought and practice that would be suitable for the modern world. Islamic modernist movements drew on concepts of civilization, progress and science that were integral to European imperialism while also constituting a critical response to the latter. In this essay, I examine the views of prominent Ottoman Muslim reformists concerning music, and situate them within a transnational debate about Islam and modernity. While the views of earlier reformers were shaped by Eurocentric notions of musical progress, an oppositional discourse emerged at the end of the nineteenth century. This discourse, associated especially with Rauf Yekta (1871–1935), appropriated the idea of ‘the Orient’ in order to establish a pan-Islamic narrative of music history, which also emphasized the scientific aspects of Islamicate music theory. In the final part of the essay, I discuss how debates about musical reform were related to the political dynamics of the late Ottoman Empire, particularly in terms of religious and ethnic identity. In conclusion, I argue that the discursive categories of the late nineteenth century continue to underly music historiographies both in the West and in other places, precisely as a consequence of the global connections that emerged during this period. In order to write more ‘global’ histories of music, it is therefore necessary to move beyond the analysis of Western colonialist representations by engaging more closely with non-European sources and discourses, which reveal more entangled and ambivalent stories about music, empire and modernity.
Future Changes in Floods, Droughts, and Their Extents in the Alps: A Sensitivity Analysis With a Non‐Stationary Stochastic Streamflow Generator
Authors: Brunner Manuela I. , Gilleland Eric 
Published: April 2024

AbstractSpatially compounding droughts and floods challenge water management and may become more severe in a warming climate. However, the influence of climate change on widespread hydrologic extremes remains largely unknown because they are neither well represented in observations nor in models. Here, we present a non‐stationary stochastic streamflow generator that captures streamflow dependencies between different catchments and represents seasonal covariations of streamflow with temperature. We run this model for 925 nearly natural catchments in the Alps to generate daily streamflow time series for a reference period and three warming levels of 1, 2, and 3°C. Then, we identify drought and flood events, determine their spatial extents, and assess changes in all of these characteristics. This sensitivity analysis for different warming levels suggests that changes in flood characteristics and spatial extent are substantially weaker than those in drought characteristics and spatial extent. While floods show changes in their timing toward earlier in the year, simulated changes in magnitude, volume, duration, and spatial extent are negligible. In contrast, droughts show changes not just in timing but also intensity, deficit, duration, and extent. Specifically, droughts are projected to intensify, last longer, and slightly increase in spatial extent, with the magnitude of change increasing with the warming level. These projected changes highlight the need to develop adaptation strategies in particular for droughts. Such adaptation strategies should go beyond local adaptation and consider that extreme events become more widespread in a warming world.
Transformation of Precursor Iron(III) Minerals in Diagenetic Fluids: Potential Origin of Gray Hematite at Vera Rubin Ridge
Authors: Knight A. L. , Mitra K. , Catalano J. G. 
Published: April 2024

AbstractCoarse‐grained (>3–5 μm) gray hematite particles occur at Vera Rubin ridge (VRR) within Gale crater, Mars. VRR has likely undergone multiple episodes of diagenesis, at least one of which resulted in the formation of gray hematite. The precursor mineralogy and nature of the diagenetic fluids that produced coarse‐grained hematite remain unknown. Analog laboratory experiments were performed on a variety of iron(III) minerals to assess the potential fluid conditions and precursor mineralogy that form coarse‐grained hematite. Gray hematite formed from the transformation of jarosite after 20 days at 200°C. Conversion was complete in chloride‐rich fluids; however, modeling indicates that at lower jarosite‐to‐water ratios, conversion is complete even in chloride‐free, sulfate‐rich conditions. No transformations of jarosite occurred when aged at 98°C. All other precursor minerals (akaganeite, ferrihydrite, goethite, and schwertmannite) did not transform or produced red, fine‐grained hematite under all conditions assessed. Additionally, seeding precursor iron(III) phases with red hematite and coarsening pre‐existing red hematite failed to produce gray hematite. These results suggest that jarosite could have been the precursor of gray hematite at VRR and that transformation is possible in both sulfate‐bearing and chloride‐bearing fluids. Jarosite produces gray hematite because the acidic conditions it generates yield both a low degree of hematite supersaturation, producing few nuclei, and high dissolved iron concentrations, enabling rapid hematite growth. Gray hematite readily forms under oxic conditions and its occurrence at VRR is not a marker for a redox interface. The associated diagenetic event was thus unlikely to have generated substantial new chemical energy for life.
Management of isocitrate dehydrogenase 1/2 mutated acute myeloid leukemia
Authors: Fruchtman Harry , Avigan Zachary M. , Waksal Julian A. , Brennan Nicole , Mascarenhas John O. 
Published: April 2024

AbstractThe emergence of next generation sequencing and widespread use of mutational profiling in acute myeloid leukemia (AML) has broadened our understanding of the heterogeneous molecular basis of the disease. Since genetic sequencing has become a standard practice, several driver mutations have been identified. Accordingly, novel targeted therapeutic agents have been developed and are now approved for the treatment of subsets of patients that carry mutations in FLT3, IDH1, and IDH2 [1, 2]. The emergence of these novel agents in AML offers patients a new modality of therapy, and shifts treatment paradigms toward individualized medicine. In this review, we outline the role of IDH mutations in malignant transformation, focus in on a novel group of targeted therapeutic agents directed toward IDH1- and IDH2-mutant AML, and explore their impact on prognosis in patients with AML.
Combination of bazedoxifene with chemotherapy and SMAC-mimetics for the treatment of colorectal cancer
Authors: Dmello Rhynelle S. , Palmieri Michelle , Thilakasiri Pathum S. , Doughty Larissa , Nero Tracy L. , Poh Ashleigh R. , To Sarah Q. , Lee Erinna F. , Douglas Fairlie W. , Mielke Lisa , Parker Michael W. , Poon Ivan K. H. , Batlle Eduard , Ernst Matthias , Chand Ashwini L. 
Published: April 2024

AbstractExcessive STAT3 signalling via gp130, the shared receptor subunit for IL-6 and IL-11, contributes to disease progression and poor survival outcomes in patients with colorectal cancer. Here, we provide evidence that bazedoxifene inhibits tumour growth via direct interaction with the gp130 receptor to suppress IL-6 and IL-11-mediated STAT3 signalling. Additionally, bazedoxifene combined with chemotherapy synergistically reduced cell proliferation and induced apoptosis in patient-derived colon cancer organoids. We elucidated that the primary mechanism of anti-tumour activity conferred by bazedoxifene treatment occurs via pro-apoptotic responses in tumour cells. Co-treatment with bazedoxifene and the SMAC-mimetics, LCL161 or Birinapant, that target the IAP family of proteins, demonstrated increased apoptosis and reduced proliferation in colorectal cancer cells. Our findings provide evidence that bazedoxifene treatment could be combined with SMAC-mimetics and chemotherapy to enhance tumour cell apoptosis in colorectal cancer, where gp130 receptor signalling promotes tumour growth and progression.
Thylakoid protein FPB1 synergistically cooperates with PAM68 to promote CP47 biogenesis and Photosystem II assembly
Authors: Zhang Lin , Ruan Junxiang , Gao Fudan , Xin Qiang , Che Li-Ping , Cai Lujuan , Liu Zekun , Kong Mengmeng , Rochaix Jean-David , Mi Hualing , Peng Lianwei 
Published: April 2024

AbstractIn chloroplasts, insertion of proteins with multiple transmembrane domains (TMDs) into thylakoid membranes usually occurs in a co-translational manner. Here, we have characterized a thylakoid protein designated FPB1 (Facilitator of PsbB biogenesis1) which together with a previously reported factor PAM68 (Photosynthesis Affected Mutant68) is involved in assisting the biogenesis of CP47, a subunit of the Photosystem II (PSII) core. Analysis by ribosome profiling reveals increased ribosome stalling when the last TMD segment of CP47 emerges from the ribosomal tunnel in fpb1 and pam68. FPB1 interacts with PAM68 and both proteins coimmunoprecipitate with SecY/E and Alb3 as well as with some ribosomal components. Thus, our data indicate that, in coordination with the SecY/E translocon and the Alb3 integrase, FPB1 synergistically cooperates with PAM68 to facilitate the co-translational integration of the last two CP47 TMDs and the large loop between them into thylakoids and the PSII core complex.
The genomic evolutionary dynamics and global circulation patterns of respiratory syncytial virus
Authors: Langedijk Annefleur C. , Vrancken Bram , Lebbink Robert Jan , Wilkins Deidre , Kelly Elizabeth J. , Baraldi Eugenio , Mascareñas de Los Santos Abiel Homero , Danilenko Daria M. , Choi Eun Hwa , Palomino María Angélica , Chi Hsin , Keller Christian , Cohen Robert , Papenburg Jesse , Pernica Jeffrey , Greenough Anne , Richmond Peter , Martinón-Torres Federico , Heikkinen Terho , Stein Renato T. , Hosoya Mitsuaki , Nunes Marta C. , Verwey Charl , Evers Anouk , Kragten-Tabatabaie Leyla , Suchard Marc A. , Kosakovsky Pond Sergei L. , Poletto Chiara , Colizza Vittoria , Lemey Philippe , Bont Louis J. ,   on behalf of the INFORM-RSV Study Group, Priante Elena , Komissarova Kseniya , Yun Ki Wook , Clement Pascale , Bauck Monica , Gupta Atul , Wadia Ushma , Rivero-Calle Irene , Lumertz Magalia , Hasimoto Koichi , Madhi Shabir A. 
Published: April 2024

AbstractRespiratory syncytial virus (RSV) is a leading cause of acute lower respiratory tract infection in young children and the second leading cause of infant death worldwide. While global circulation has been extensively studied for respiratory viruses such as seasonal influenza, and more recently also in great detail for SARS-CoV-2, a lack of global multi-annual sampling of complete RSV genomes limits our understanding of RSV molecular epidemiology. Here, we capitalise on the genomic surveillance by the INFORM-RSV study and apply phylodynamic approaches to uncover how selection and neutral epidemiological processes shape RSV diversity. Using complete viral genome sequences, we show similar patterns of site-specific diversifying selection among RSVA and RSVB and recover the imprint of non-neutral epidemic processes on their genealogies. Using a phylogeographic approach, we provide evidence for air travel governing the global patterns of RSVA and RSVB spread, which results in a considerable degree of phylogenetic mixing across countries. Our findings highlight the potential of systematic global RSV genomic surveillance for transforming our understanding of global RSV spread.
Immunoglobulin G N-glycan markers of accelerated biological aging during chronic HIV infection
Authors: Giron Leila B. , Liu Qin , Adeniji Opeyemi S. , Yin Xiangfan , Kannan Toshitha , Ding Jianyi , Lu David Y. , Langan Susan , Zhang Jinbing , Azevedo Joao L. L. C. , Li Shuk Hang , Shalygin Sergei , Azadi Parastoo , Hanna David B. , Ofotokun Igho , Lazar Jason , Fischl Margaret A. , Haberlen Sabina , Macatangay Bernard , Adimora Adaora A. , Jamieson Beth D. , Rinaldo Charles , Merenstein Daniel , Roan Nadia R. , Kutsch Olaf , Gange Stephen , Wolinsky Steven M. , Witt Mallory D. , Post Wendy S. , Kossenkov Andrew , Landay Alan L. , Frank Ian , Tien Phyllis C. , Gross Robert , Brown Todd T. , Abdel-Mohsen Mohamed 
Published: April 2024

AbstractPeople living with HIV (PLWH) experience increased vulnerability to premature aging and inflammation-associated comorbidities, even when HIV replication is suppressed by antiretroviral therapy (ART). However, the factors associated with this vulnerability remain uncertain. In the general population, alterations in the N-glycans on IgGs trigger inflammation and precede the onset of aging-associated diseases. Here, we investigate the IgG N-glycans in cross-sectional and longitudinal samples from 1214 women and men, living with and without HIV. PLWH exhibit an accelerated accumulation of pro-aging-associated glycan alterations and heightened expression of senescence-associated glycan-degrading enzymes compared to controls. These alterations correlate with elevated markers of inflammation and the severity of comorbidities, potentially preceding the development of such comorbidities. Mechanistically, HIV-specific antibodies glycoengineered with these alterations exhibit a reduced ability to elicit anti-HIV Fc-mediated immune activities. These findings hold potential for the development of biomarkers and tools to identify and prevent premature aging and comorbidities in PLWH.
Giant Faraday rotation in atomically thin semiconductors
Authors: Carey Benjamin , Wessling Nils Kolja , Steeger Paul , Schmidt Robert , Michaelis de Vasconcellos Steffen , Bratschitsch Rudolf , Arora Ashish 
Published: April 2024

AbstractFaraday rotation is a fundamental effect in the magneto-optical response of solids, liquids and gases. Materials with a large Verdet constant find applications in optical modulators, sensors and non-reciprocal devices, such as optical isolators. Here, we demonstrate that the plane of polarization of light exhibits a giant Faraday rotation of several degrees around the A exciton transition in hBN-encapsulated monolayers of WSe2 and MoSe2 under moderate magnetic fields. This results in the highest known Verdet constant of -1.9 × 107 deg T−1 cm−1 for any material in the visible regime. Additionally, interlayer excitons in hBN-encapsulated bilayer MoS2 exhibit a large Verdet constant (VIL ≈ +2 × 105 deg T−1 cm−2) of opposite sign compared to A excitons in monolayers. The giant Faraday rotation is due to the giant oscillator strength and high g-factor of the excitons in atomically thin semiconducting transition metal dichalcogenides. We deduce the complete in-plane complex dielectric tensor of hBN-encapsulated WSe2 and MoSe2 monolayers, which is vital for the prediction of Kerr, Faraday and magneto-circular dichroism spectra of 2D heterostructures. Our results pose a crucial advance in the potential usage of two-dimensional materials in ultrathin optical polarization devices.
Single-cell and spatial RNA sequencing reveal the spatiotemporal trajectories of fruit senescence
Authors: Li Xin , Li Bairu , Gu Shaobin , Pang Xinyue , Mason Patrick , Yuan Jiangfeng , Jia Jingyu , Sun Jiaju , Zhao Chunyan , Henry Robert 
Published: April 2024

AbstractThe senescence of fruit is a complex physiological process, with various cell types within the pericarp, making it highly challenging to elucidate their individual roles in fruit senescence. In this study, a single-cell expression atlas of the pericarp of pitaya (Hylocereus undatus) is constructed, revealing exocarp and mesocarp cells undergoing the most significant changes during the fruit senescence process. Pseudotime analysis establishes cellular differentiation and gene expression trajectories during senescence. Early-stage oxidative stress imbalance is followed by the activation of resistance in exocarp cells, subsequently senescence-associated proteins accumulate in the mesocarp cells at late-stage senescence. The central role of the early response factor HuCMB1 is unveiled in the senescence regulatory network. This study provides a spatiotemporal perspective for a deeper understanding of the dynamic senescence process in plants.
Antigen-specific Fab profiling achieves molecular-resolution analysis of human autoantibody repertoires in rheumatoid arthritis
Authors: Stork Eva Maria , van Rijswijck Danique M. H. , van Schie Karin A. , Hoek Max , Kissel Theresa , Scherer Hans Ulrich , Huizinga Tom W. J. , Heck Albert J. R. , Toes Rene E. M. , Bondt Albert 
Published: April 2024

AbstractThe presence of autoantibodies is a defining feature of many autoimmune diseases. The number of unique autoantibody clones is conceivably limited by immune tolerance mechanisms, but unknown due to limitations of the currently applied technologies. Here, we introduce an autoantigen-specific liquid chromatography-mass spectrometry-based IgG1 Fab profiling approach using the anti-citrullinated protein antibody (ACPA) repertoire in rheumatoid arthritis (RA) as an example. We show that each patient harbors a unique and diverse ACPA IgG1 repertoire dominated by only a few antibody clones. In contrast to the total plasma IgG1 antibody repertoire, the ACPA IgG1 sub-repertoire is characterised by an expansion of antibodies that harbor one, two or even more Fab glycans, and different glycovariants of the same clone can be detected. Together, our data indicate that the autoantibody response in a prominent human autoimmune disease is complex, unique to each patient and dominated by a relatively low number of clones.
A bionic self-driven retinomorphic eye with ionogel photosynaptic retina
Authors: Luo Xu , Chen Chen , He Zixi , Wang Min , Pan Keyuan , Dong Xuemei , Li Zifan , Liu Bin , Zhang Zicheng , Wu Yueyue , Ban Chaoyi , Chen Rong , Zhang Dengfeng , Wang Kaili , Wang Qiye , Li Junyue , Lu Gang , Liu Juqing , Liu Zhengdong , Huang Wei 
Published: April 2024

AbstractBioinspired bionic eyes should be self-driving, repairable and conformal to arbitrary geometries. Such eye would enable wide-field detection and efficient visual signal processing without requiring external energy, along with retinal transplantation by replacing dysfunctional photoreceptors with healthy ones for vision restoration. A variety of artificial eyes have been constructed with hemispherical silicon, perovskite and heterostructure photoreceptors, but creating zero-powered retinomorphic system with transplantable conformal features remains elusive. By combining neuromorphic principle with retinal and ionoelastomer engineering, we demonstrate a self-driven hemispherical retinomorphic eye with elastomeric retina made of ionogel heterojunction as photoreceptors. The receptor driven by photothermoelectric effect shows photoperception with broadband light detection (365 to 970 nm), wide field-of-view (180°) and photosynaptic (paired-pulse facilitation index, 153%) behaviors for biosimilar visual learning. The retinal photoreceptors are transplantable and conformal to any complex surface, enabling visual restoration for dynamic optical imaging and motion tracking.
Thermally stable Ni foam-supported inverse CeAlOx/Ni ensemble as an active structured catalyst for CO2 hydrogenation to methane
Authors: Tang Xin , Song Chuqiao , Li Haibo , Liu Wenyu , Hu Xinyu , Chen Qiaoli , Lu Hanfeng , Yao Siyu , Li Xiao-nian , Lin Lili 
Published: April 2024

AbstractNickel is the most widely used inexpensive active metal center of the heterogeneous catalysts for CO2 hydrogenation to methane. However, Ni-based catalysts suffer from severe deactivation in CO2 methanation reaction due to the irreversible sintering and coke deposition caused by the inevitable localized hotspots generated during the vigorously exothermic reaction. Herein, we demonstrate the inverse CeAlOx/Ni composite constructed on the Ni-foam structure support realizes remarkable CO2 methanation catalytic activity and stability in a wide operation temperature range from 240 to 600 °C. Significantly, CeAlOx/Ni/Ni-foam catalyst maintains its initial activity after seven drastic heating-cooling cycles from RT to 240 to 600 °C. Meanwhile, the structure catalyst also shows water resistance and long-term stability under reaction condition. The promising thermal stability and water-resistance of CeAlOx/Ni/Ni-foam originate from the excellent heat and mass transport efficiency which eliminates local hotspots and the formation of Ni-foam stabilized CeAlOx/Ni inverse composites which effectively anchored the active species and prevents carbon deposition from CH4 decomposition.
Integrated proteomics reveals autophagy landscape and an autophagy receptor controlling PKA-RI complex homeostasis in neurons
Authors: Zhou Xiaoting , Lee You-Kyung , Li Xianting , Kim Henry , Sanchez-Priego Carlos , Han Xian , Tan Haiyan , Zhou Suiping , Fu Yingxue , Purtell Kerry , Wang Qian , Holstein Gay R. , Tang Beisha , Peng Junmin , Yang Nan , Yue Zhenyu 
Published: April 2024

AbstractAutophagy is a conserved, catabolic process essential for maintaining cellular homeostasis. Malfunctional autophagy contributes to neurodevelopmental and neurodegenerative diseases. However, the exact role and targets of autophagy in human neurons remain elusive. Here we report a systematic investigation of neuronal autophagy targets through integrated proteomics. Deep proteomic profiling of multiple autophagy-deficient lines of human induced neurons, mouse brains, and brain LC3-interactome reveals roles of neuronal autophagy in targeting proteins of multiple cellular organelles/pathways, including endoplasmic reticulum (ER), mitochondria, endosome, Golgi apparatus, synaptic vesicle (SV) for degradation. By combining phosphoproteomics and functional analysis in human and mouse neurons, we uncovered a function of neuronal autophagy in controlling cAMP-PKA and c-FOS-mediated neuronal activity through selective degradation of the protein kinase A - cAMP-binding regulatory (R)-subunit I (PKA-RI) complex. Lack of AKAP11 causes accumulation of the PKA-RI complex in the soma and neurites, demonstrating a constant clearance of PKA-RI complex through AKAP11-mediated degradation in neurons. Our study thus reveals the landscape of autophagy degradation in human neurons and identifies a physiological function of autophagy in controlling homeostasis of PKA-RI complex and specific PKA activity in neurons.
A primary sensory cortical interareal feedforward inhibitory circuit for tacto-visual integration
Authors: Weiler Simon , Rahmati Vahid , Isstas Marcel , Wutke Johann , Stark Andreas Walter , Franke Christian , Graf Jürgen , Geis Christian , Witte Otto W. , Hübener Mark , Bolz Jürgen , Margrie Troy W. , Holthoff Knut , Teichert Manuel 
Published: April 2024

AbstractTactile sensation and vision are often both utilized for the exploration of objects that are within reach though it is not known whether or how these two distinct sensory systems combine such information. Here in mice, we used a combination of stereo photogrammetry for 3D reconstruction of the whisker array, brain-wide anatomical tracing and functional connectivity analysis to explore the possibility of tacto-visual convergence in sensory space and within the circuitry of the primary visual cortex (VISp). Strikingly, we find that stimulation of the contralateral whisker array suppresses visually evoked activity in a tacto-visual sub-region of VISp whose visual space representation closely overlaps with the whisker search space. This suppression is mediated by local fast-spiking interneurons that receive a direct cortico-cortical input predominantly from layer 6 neurons located in the posterior primary somatosensory barrel cortex (SSp-bfd). These data demonstrate functional convergence within and between two primary sensory cortical areas for multisensory object detection and recognition.