bluuebunny/crossref_metadata_2025_split huggingface dataset:
Yeast mannan rich fraction positively influences microbiome uniformity, productivity associated taxa, and lay performance
Authors: Leigh Robert J. , Corrigan Aoife , Murphy Richard A. , Taylor-Pickard Jules , Moran Colm A. , Walsh Fiona 
Published: March 2024

Abstract
Background
Alternatives to antibiotic as growth promoters in agriculture, such as supplemental prebiotics, are required to maintain healthy and high performing animals without directly contributing to antimicrobial resistance bioburden. While the gut microbiota of broiler hens has been well established and successfully correlated to performance, to our knowledge, a study has yet to be completed on the effect of prebiotic supplementation on correlating the mature laying hen productivity and microbiota. This study focused on establishing the impact of a yeast derived prebiotic, mannan rich fraction (MRF), on the cecal microbiota of late laying hens. This study benefitted from large sample sizes so intra- and intergroup variation effects could be statistically accounted for.

Results
Taxonomic richness was significantly greater at all taxonomic ranks and taxonomic evenness was significantly lower for all taxonomic ranks in MRF-supplemented birds (P < 0.005). Use of principal coordinate analyses and principal component analyses found significant variation between treatment groups. When assessed for compositional uniformity (an indicator of flock health), microbiota in MRF-supplemented birds was more uniform than control birds at the species level. From a food safety and animal welfare perspective, Campylobacter jejuni was significantly lower in abundance in MRF-supplemented birds. In this study, species associated with high weight gain (an anticorrelator of performance in laying hens) were significantly lower in abundance in laying hens while health-correlated butyrate and propionate producing species were significantly greater in abundance in MRF-supplemented birds.

Conclusions
The use of prebiotics may be a key factor in controlling the microbiota balance limiting agri-food chain pathogen persistence and in promoting uniformity. In previous studies, increased α- and β-diversity indices were determinants of pathogen mitigation and performance. MRF-supplemented birds in this study established greater α- and β-diversity indices in post-peak laying hens, greater compositional uniformity across samples, a lower pathogenic bioburden and a greater abundance of correlators of performance.
Concomitant thyroiditis and orchitis induced by immune checkpoint inhibitors detected on [18F]FDG PET/CT
Authors: Filippi Luca , Proietti Ilaria , Morea Simone , Potenza Concetta 
Published: March 2024

Abstract
Background
The clinical management of malignant melanoma (MM) has undergone a significant revolution with the implementation of immune checkpoint inhibitors (ICIs). While these therapeutic agents stimulate the host immune system against cancer, they may also lead to immune-related adverse events (IrAEs). Positron emission computed tomography (PET/CT) with 2-deoxy-2-[18F]fluoro-d-glucose ([18F]FDG) has proven successful in detecting IrAEs in cancer patients undergoing ICI. In our case, we report a rare occurrence of ICIs-induced concomitant thyroiditis and orchitis detected on [18F]FDG PET/CT.

Case presentation
We present a case involving a 61-year-old man referred to our hospital due to MM. Following surgical excision and sentinel lymph node mapping, he underwent an initial [18F]FDG PET/CT, which yielded negative results. However, a follow-up PET/CT after 9 months revealed metastases in the lungs and lymph nodes. Subsequently, he initiated an ICI-based therapeutic regimen. After 3 months, he reported progressively worsening fatigue and the onset of testicular pain. A testicular ultrasound showed heterogeneous echotexture in both testicles with mildly increased vascularity. A subsequent PET/CT demonstrated complete regression of previously described pathological lesions in the lungs and metastatic lymph nodes. However, diffusely increased tracer uptake was observed in both the thyroid gland and testicles, findings absent in the pre-ICI examination. These were interpreted as IrAEs and promptly treated with corticosteroids, resulting in complete resolution of symptoms.

Conclusions
[18F]FDG PET/CT plays a crucial role in staging and monitoring treatment response in cancer patients. When assessing subjects undergoing ICI-based therapies, particular emphasis should be given to detecting unusual IrAEs, as exemplified in our case.
African women and young people as agriculture service providers—business models, benefits, gaps and opportunities
Authors: Kadzamira Mariam , Chege Florence , Suntharalingam Chubashini , Bundi Mary , Likoko Linda , Magero Deogratius , Romney Dannie , Kansiime Monica , Mulema Joseph 
Published: March 2024

Abstract
We use a combination of a global desk review of the literature with information from an on-going action research in Kenya to provide insights into the main characteristics, benefits and shortfalls of business models for engaging women and young people in agricultural service provision in Africa. The findings demonstrate that the engagement of African women and young people in agricultural service provision is not a panacea to the challenges they face. However various business models have been successful in contributing to economic empowerment, to increasing entrepreneurial activities and to upskilling of women and young people engaged as service providers. Business models that are successful are place-based and people-focused, market-driven and focused on value chains. Challenges however abound due to various factors, hence for sustainability there is need for multi-sectoral inter-institutional collaboration that pulls in funding and which makes a case for private sector buy-in. Future research should focus on increasing the evidence base to understand if successes with inclusion of women and young people in agricultural service provision has an influence on emerging agricultural policy. Research should also rigorously assess the extent to which successful agricultural service provision business models are engendered, provide sufficient levels of renumeration and the extent to which they impact farmer outcomes.
Development and application of the Demands for Population Health Interventions (Depth) framework for categorising the agentic demands of population health interventions
Authors: Garrott Kate , Ogilvie David , Panter Jenna , Petticrew Mark , Sowden Amanda , Jones Catrin P. , Foubister Campbell , Lawlor Emma R. , Ikeda Erika , Patterson Richard , van Tulleken Dolly , Armstrong-Moore Roxanne , Vethanayakam Gokulan , Bo Lorna , White Martin , Adams Jean 
Published: March 2024

Abstract
Background
The ‘agentic demand’ of population health interventions (PHIs) refers to the capacity, resources and freedom to act that interventions demand of their recipients to benefit, which have a socio-economical pattern. Highly agentic interventions, e.g. information campaigns, rely on recipients noticing and responding to the intervention and thus might affect intervention effectiveness and equity. The absence of an adequate framework to classify agentic demands limits the fields’ ability to systematically explore these associations.

Methods
We systematically developed the Demands for Population Health Interventions (Depth) framework using an iterative approach: (1) developing the Depth framework by systematically identifying examples of PHIs aiming to promote healthier diets and physical activity, coding of intervention actors and actions and synthesising the data to develop the framework; (2) testing the Depth framework in online workshops with academic and policy experts and a quantitative reliability assessment. We applied the final framework in a proof-of-concept review, extracting studies from three existing equity-focused systematic reviews on framework category, overall effectiveness and differential socioeconomic effects and visualised the findings in harvest plots.

Results
The Depth framework identifies three constructs influencing agentic demand: exposure — initial contact with intervention (two levels), mechanism of action — how the intervention enables or discourages behaviour (five levels) and engagement — recipient response (two levels). When combined, these constructs form a matrix of 20 possible classifications. In the proof-of-concept review, we classified all components of 31 interventions according to the Depth framework. Intervention components were concentrated in a small number of Depth classifications; Depth classification appeared to be related to intervention equity but not effectiveness.

Conclusions
This framework holds potential for future research, policy and practice, facilitating the design, selection and evaluation of interventions and evidence synthesis.
A systematic review of COVID-19 and the presentation of avoidant/restrictive food intake disorder and avoidant/restrictive food intake disorder-like symptoms
Authors: Maunder Kristen , Markey Oscar , Batchelor Rachel , McNicholas Fiona 
Published: March 2024

Background
The adverse effects of COVID-19 and the associated restrictions on eating disorder populations have been discussed in recent literature. However, little is known about the presentation of cases with avoidant/restrictive food intake disorder (ARFID) during this period.

Aims
To explore the extent of the literature on the presentation of ARFID, and ARFID-like cases, during the COVID-19 pandemic.

Method
Cochrane Library, CINAHL (EBSCO), PsycINFO (EBSCO), EMBASE (Ovid) and Medline (Ovid) were searched for publications between March 2020 and May 2023. Google Scholar and reference lists were hand searched. At least two reviewers independently screened each paper. Narrative synthesis was used.

Results
Seven papers were included: four case reports and three cohort studies (total ARFID sample of 46). Included papers were assessed as having high (n = 3) or moderate (n = 4) quality. Findings did not suggest an increase in ARFID cases during the COVID-19 pandemic, although it is unclear if this is because of a lack of impact or underrecognition of ARFID. A need for a multidisciplinary approach to differentiate between ARFID and organic causes of ARFID-like presentations (e.g. gastrointestinal effects of COVID-19) was highlighted.

Conclusions
Publications specifically pertaining to ARFID presentations during the COVID-19 pandemic have been few. Papers found have been of small sample sizes and lack subanalyses for ARFID within broader eating disorder samples. Continued surveillance is needed to evaluate any COVID-19-specific effects on the development, identification, treatment and outcomes of ARFID.
Trajectory of adjustment difficulties following disaster: 10-year longitudinal cohort study
Authors: Pacella Belinda J. , Cowlishaw Sean , Gibbs Lisa , Bryant Richard A. , Brady Kate , Gallagher Colin , Molyneaux Robyn , Gibson Kari , Block Karen , Harms Louise , Forbes David , O'Donnell Meaghan L. 
Published: March 2024

Background
Although much is known about psychopathology such as post-traumatic stress disorder (PTSD) and depression following bushfire (also known as wildfire), little is known about prevalence, trajectory and impacts for those experiencing general adjustment difficulties following exposure to these now-common events.

Aims
This was an exploratory analysis of a large cohort study that examined the prevalence, trajectory and risk factors of probable adjustment disorder over a 10-year period following bushfire exposure.

Method
The Beyond Bushfires study assessed individuals exposed to a large and deadly bushfire across three time points spanning 10 years. Self-report survey data from participants from areas with moderate and high levels of fire-affectedness were analysed: n = 802 participants at Wave 1 (3–4 years post-fires), n = 596 at Wave 2 (5 years post-fires) and n = 436 at Wave 3 (10 years post-fires). Surveys indexed fire-related experiences and post-fire stressors, and comprised the six-item Kessler Psychological Distress Scale (probable adjustment disorder index), four-item Posttraumatic Stress Disorder Checklist (probable fire-related PTSD) and nine-item Patient Health Questionnaire (probable major depressive episode).

Results
Prevalence of probable adjustment disorder was 16% (Wave 1), 15% (Wave 2) and 19% (Wave 3). Probable adjustment disorder at 3–4 years post-fires predicted a five-fold increase in risk for escalating to severe psychiatric disorder (i.e. probable fire-related PTSD/major depressive episode) at 10 years post-fires, and was associated with post-fire income and relationship stressors.

Conclusions
Adjustment difficulties are prevalent post-disaster, many of which are maintained and exacerbated over time, resulting in increased risk for later disorder and adaptation difficulties. Psychosocial interventions supporting survivors with adjustment difficulties may prevent progression to more severe disorder.
Hypergonadotropic Hypogonadism Due to Transaldolase Deficiency: Two Cases and Literature Review
Authors: Takaleh Akram , Abunamous Nasser , AlShamsi Aisha , Alhassani Noura , Almazrouei Raya 
Published: March 2024

Abstract
Transaldolase deficiency is a rare autosomal recessive inborn error of carbohydrate metabolism caused by pathogenic/likely pathogenic biallelic mutations in the TALDO1 gene. This disorder is characterized by multisystem involvement with variable phenotypes, including intrauterine growth restriction; dysmorphic features; abnormal skin; hepatosplenomegaly; cytopenia; and cardiac, renal, and endocrine abnormalities. Herein, we present two Emirati patients with hypergonadotropic hypogonadism due to transaldolase deficiency and variable phenotypes of systemic involvement.
Financial Incentives for Physical Activity and Sports Participation in Young People
Authors: Simpson Catherine EM , Curtis Rachel G , Virgara Rosa , Crisp Michelle , Licari Simone , James Michaela , Reece Lindsey , Maher Carol A 
Published: March 2024

Abstract
Physical inactivity is a global health problem. Childhood is an opportune time to establish healthy physical activity behaviors, including the participation in organized physical activity, such as sports. We hypothesize that financial incentives can improve young people’s participation in physical activity and sports. The design of the incentive and the context in which it operates is crucial to its success.
Are Recreational Sports a Relic of the Past OR a Solution for the Future?
Authors: Butler Lauren S. , Janosky Joseph , Knell Gregory , Ulman Sophia , Latz Kevin 
Published: March 2024

Abstract
Children's participation in sport is a critical component to their physical and social development and as such, efforts should be made to provide all children with the opportunity to play. In recent years, there has been an observed shift in the focus of youth sports from that of participation for the health benefits of physical activity and fun to that of winning and competing. As a result, there has been a rise in club sports offerings and a subsequent reduction in recreational sports opportunities. This change presents unique challenges to children's access to sport and may not adequately support their overall physical, social, and emotional development. This commentary will discuss the benefits and barriers to increasing recreational sport opportunities using the Social Ecological Model as a framework. It also will propose solutions that can be implemented at the intrapersonal, interpersonal, organizational, community, and public policy levels to revive recreational sports.
Frontiers in Operations: Waiting Experience in Open-Shop Service Networks: Improvements via Flow Analytics and Automation
Authors: Chen Manlu , Baron Opher , Mandelbaum Avishai , Wang Jianfu , Yom-Tov Galit B. , Arber Nadir 
Published: March 2024

Problem definition: We study open-shop service networks where customers go through multiple services. We were motivated by a partnering health screening clinic, where customers are routed by a dispatcher and operational performance is measured at two levels: micro-level, via waits for individual services, and macro-level, via overall wait. Both measures reflect customer experience and could support its management. Our analysis revealed that waits were long and increased along the service process. Such long waits give rise to negative waiting experience and the increasing shape is detrimental as it is known to create perceived waits that are even longer. Our goal is hence to analyze strategies that shape and improve customers’ perceived experience. Methodology/results: Analytically, we use a stylized two-station open-shop network to show that prioritizing advanced customers, jointly with pooling (virtual) queues, can improve both macro- and micro-level performance. We validate these findings with a simulation model, calibrated with our clinic’s data. Practically, we find that an automated routing system (ARS), recently implemented in the clinic, had a negligible impact on overall wait—It simply redistributed waiting among wait-for-routing and wait-for-service. However, ARS renders applicable sophisticated priority and routing policies (that were infeasible under the manual routing practice), specifically the ones arising from the present research. Managerial implications: Our study amplifies performance benefits of accounting for individual customers’ system status in addition to station-level load information. We offer insights into the implementation of new technologies: Firms better plan for fundamental changes in their operation rather than harness new technology to their existing operation, which may be suboptimal due to past technical limitations. History: This paper has been accepted in the Manufacturing & Service Operations Management Frontiers in Operations Initiative. Funding: M. Chen acknowledges the support from the National Natural Science Foundation of China [Grant 72301280]. O. Baron acknowledges the support from the Natural Science and Engineering Research Council of Canada. J. Wang acknowledges the support from the City University of Hong Kong [Grant 11505421]. A. Mandelbaum is partially supported by the Israel Science Foundation [Grant 491/22]. Supplemental Material: The online appendices are available at https://doi.org/10.1287/msom.2022.0590 .
Halicin remains active against Staphylococcus aureus in biofilms grown on orthopaedically relevant substrates
Authors: Higashihira Shota , Simpson Stefanie J. , Morita Akira , Suryavanshi Joash R. , Arnold Christopher J. , Natoli Roman M. , Greenfield Edward M. 
Published: March 2024

AimsBiofilm infections are among the most challenging complications in orthopaedics, as bacteria within the biofilms are protected from the host immune system and many antibiotics. Halicin exhibits broad-spectrum activity against many planktonic bacteria, and previous studies have demonstrated that halicin is also effective against Staphylococcus aureus biofilms grown on polystyrene or polypropylene substrates. However, the effectiveness of many antibiotics can be substantially altered depending on which orthopaedically relevant substrates the biofilms grow. This study, therefore, evaluated the activity of halicin against less mature and more mature S. aureus biofilms grown on titanium alloy, cobalt-chrome, ultra-high molecular weight polyethylene (UHMWPE), devitalized muscle, or devitalized bone.MethodsS. aureus-Xen36 biofilms were grown on the various substrates for 24 hours or seven days. Biofilms were incubated with various concentrations of halicin or vancomycin and then allowed to recover without antibiotics. Minimal biofilm eradication concentrations (MBECs) were defined by CFU counting and resazurin reduction assays, and were compared with the planktonic minimal inhibitory concentrations (MICs).ResultsHalicin continued to exert significantly (p < 0.01) more antibacterial activity against biofilms grown on all tested orthopaedically relevant substrates than vancomycin, an antibiotic known to be affected by biofilm maturity. For example, halicin MBECs against both less mature and more mature biofilms were ten-fold to 40-fold higher than its MIC. In contrast, vancomycin MBECs against the less mature biofilms were 50-fold to 200-fold higher than its MIC, and 100-fold to 400-fold higher against the more mature biofilms.ConclusionHalicin is a promising antibiotic that should be tested in animal models of orthopaedic infection.Cite this article: Bone Joint Res 2024;13(3):101–109.
Delving into public-expenditure elasticity: Evidence from a National Health Service acute-care hospital network
Authors: Comendeiro-Maaløe Micaela , Ridao-Lopez Manuel , Bernal-Delgado Enrique , Sansó-Rosselló Andreu 
Published: March 2024

Introduction
The sustainability of public hospital financing in Spain is a recurring issue, given its representativeness in annual public healthcare budgets which must adapt to the macroeconomic challenges that influence the evolution of spending. Knowing whether the responsiveness of hospital expenditure to its determinants (need, utilisation, and quasi-prices) varies according to the type of hospital could help better design strategies aimed at optimising performance.

Methods
Using SARIMAX models, we dynamically assess unique nationwide monthly activity data over a 14-year period from 274 acute-care hospitals in the Spanish National Health Service network, clustering these providers according to the average severity of the episodes treated.

Results
All groups showed seasonal patterns and increasing trends in the evolution of expenditure. The fourth quartile of hospitals, treating the most severe episodes and accounting for more than 50% of expenditure, is the most sensitive to quasi-price factors, particularly the number of beds per hospital. Meanwhile, the first quartile of hospitals, which treat the least severe episodes and account for 10% of expenditure, is most sensitive to quantity factors, for which expenditure showed an elasticity above one, while factors of production were not affected.

Conclusions
Belonging to one or another cluster of hospitals means that the determinants of expenditure have a different impact and intensity. The system should focus on these differences in order to optimally modulate expenditure not only according to the needs of the population, but also according to the macroeconomic situation, while leaving hospitals room for manoeuvre in case of unforeseen events. The findings suggest strengthening a network of smaller hospitals (Group 1)–closer to their reference population, focused on managing and responding to chronicity and stabilising acute events–prior to transfer to tertiary hospitals (Group 4)–larger but appropriately sized, specialising in solving acute and complex health problems–when needed.