bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psoriasis and its Impact on Close Relatives and Partners of Patients – A Cross-Sectional Questionnaire Study
Authors: Grossschaedl Katja , Weger Wolfgang , Graier Thomas , Salmhofer Wolfgang , Mrowietz Ulrich , Wolf Peter 
Published: March 2024

Abstract

Background
Little is known about the exact impact of psoriasis on the disease burden of close relatives and partners of those affected by the disease.

Objectives
The aim of this single-centre cross-sectional study was to evaluate the quality of life in psoriasis patients and the impact of disease on partners and close relatives.

Methods
250 plaque-type psoriasis patients (58.4% males and 41.6% females) with mostly treatment-controlled disease (mean PASI of 1.7 and Dermatology Life Quality Index (DLQI) of 4.1) were recruited from the Psoriasis Registry Austria (PsoRA) and their close relatives and partners were invited to participate in the study. Patient Family Impact Score (PFIS) was calculated from the FamilyPso questionnaire data to establish categories of disease burden in close relatives and partners.

Results
Valid FamilyPso questionnaires were returned from 153 (61.2%) close relatives and partners. Correlation analysis revealed a significant association between PASI and DLQI (r = 0.512, p &lt; 0.001), PASI and PFIS (r = 0.228, p = 0.006), and DLQI and PFIS (r = 0.210, p = 0.014). An at least small or larger impairment of life quality (DLQI ≥ 2) was observed in 46.7% of psoriasis patients, despite treatment. A small or larger disease burden was detected in nearly 78.7% of the male and 77.3% of the female relatives and partners quantified with categorized PFIS.

Conclusions
The study revealed a significant impact of patients’ psoriasis on the disease burden of close relatives and partners, depending on the severity of PASI and extent of quality of life disruption in patients. The gender of the relatives and partners had no impact on the PFIS.
A Novel Non‐Destructive Rapid Tool for Estimating Amino Acid Composition and Secondary Structures of Proteins in Solution
Authors: Altangerel Narangerel , Neuman Benjamin W. , Hemmer Philip R. , Yakovlev Vladislav. V. , Sokolov Alexei V. , Scully Marlan O. 
Published: March 2024

AbstractAmino‐acid protein composition plays an important role in biology, medicine, and nutrition. Here, a groundbreaking protein analysis technique that quickly estimates amino acid composition and secondary structure across various protein sizes, while maintaining their natural states is introduced and validated. This method combines multivariate statistics and the thermostable Raman interaction profiling (TRIP) technique, eliminating the need for complex preparations. In order to validate the approach, the Raman spectra are constructed of seven proteins of varying sizes by utilizing their amino acid frequencies and the Raman spectra of individual amino acids. These constructed spectra exhibit a close resemblance to the actual measured Raman spectra. Specific vibrational modes tied to free amino and carboxyl termini of the amino acids disappear as signals linked to secondary structures emerged under TRIP conditions. Furthermore, the technique is used inversely to successfully estimate amino acid compositions and secondary structures of unknown proteins across a range of sizes, achieving impressive accuracy ranging between 1.47% and 5.77% of root mean square errors (RMSE). These results extend the uses for TRIP beyond interaction profiling, to probe amino acid composition and structure.
Web‐shear capacities of composite hollow‐core slabs with core‐filling and topping concretes
Authors: Han Sun‐Jin , Joo Hyo‐Eun , Kim Jae Hyun , Heo Inwook , Kim Kang Su 
Published: March 2024

AbstractThis paper presents an experimental shear test performed to investigate the web‐shear capacity of composite hollow‐core slabs (HCS) with cast‐in‐place (CIP) concrete. Five HCS specimens are fabricated, and the presence of a topping slab and number of cores strengthened by core‐filling concrete are set as key test variables. The shear force–displacement responses of the specimens, patterns of cracks occurring in the HCS and filled cores, strain behavior of stirrups, and composite action between the HCS and CIP concrete are measured and analyzed comprehensively. In addition, the web‐shear capacity of the composite HCS with CIP concrete is calculated based on elasticity theory and the transformed area method, in which the residual stress ratio factor is introduced to reflect the shear contribution of the core‐filling concrete after its shear cracking. Moreover, a practical equation is proposed to allow structural engineers to easily perform the shear‐strengthening design of HCS via the core‐filling method. The detailed model and the simplified equation accurately evaluate the web‐shear capacities of the HCS specimens.
Multi-trace YMS amplitudes from soft behavior
Authors: Du Yi-Jian , Zhou Kang 
Published: March 2024

Abstract
Tree level multi-trace Yang-Mills-scalar (YMS) amplitudes have been shown to satisfy a recursive expansion formula, which expresses any YMS amplitude by those with fewer gluons and/or scalar traces. In an earlier work, the single-trace expansion formula has been shown to be determined by the universality of soft behavior. This approach is nevertheless not extended to multi-trace case in a straightforward way. In this paper, we derive the expansion formula of tree-level multi-trace YMS amplitudes in a bottom-up way: we first determine the simplest amplitude, the double-trace pure scalar amplitude which involves two scalars in each trace. Then insert more scalars to one of the traces. Based on this amplitude, we further obtain the double-soft behavior when the trace contains only two scalars is soft. The multi-trace amplitudes with more scalars and more gluons finally follow from the double-soft behavior as well as the single-soft behaviors which has been derived before.
4d crystal melting, toric Calabi-Yau 4-folds and brane brick models
Authors: Franco Sebastián 
Published: March 2024

Abstract
We introduce a class of 4-dimensional crystal melting models that count the BPS bound state of branes on toric Calabi-Yau 4-folds. The crystalline structure is determined by the brane brick model associated to the Calabi-Yau 4-fold under consideration or, equivalently, its dual periodic quiver. The crystals provide a discretized version of the underlying toric geometries. We introduce various techniques to visualize crystals and their melting configurations, including 3-dimensional slicing and Hasse diagrams. We illustrate the construction with the D0-D8 system on $${\mathbb{C}}$$4. Finally, we outline how our proposal generalizes to arbitrary toric CY 4-folds and general brane configurations.
Solutions of the Yang–Baxter Equation and Strong Semilattices of Skew Braces
Authors: Catino Francesco , Mazzotta Marzia , Stefanelli Paola 
Published: March 2024

AbstractWe prove that any set-theoretic solution of the Yang–Baxter equation associated with a dual weak brace is a strong semilattice of non-degenerate bijective solutions. This fact makes use of the description of any dual weak brace S we provide in terms of strong semilattice Y of skew braces $$B_\alpha $$

B
α

, with $$\alpha \in Y$$

α
∈
Y

. Additionally, we describe the ideals of S and study its nilpotency by correlating it to that of each skew brace $$B_\alpha $$

B
α

.
On the separation property and the global attractor for the nonlocal Cahn-Hilliard equation in three dimensions
Authors: Giorgini Andrea 
Published: March 2024

AbstractWe consider the nonlocal Cahn-Hilliard equation with constant mobility and singular potential in three dimensional bounded and smooth domains. This model describes phase separation in binary fluid mixtures. Given any global solution (whose existence and uniqueness are already known), we prove the so-called instantaneous and uniform separation property: any global solution with initial finite energy is globally confined (in the $$L^\infty $$

L
∞

metric) in the interval $$[-1+\delta ,1-\delta ]$$

[
-
1
+
δ
,
1
-
δ
]

on the time interval $$[\tau ,\infty )$$

[
τ
,
∞
)

for any $$\tau >0$$

τ
>
0

, where $$\delta $$
δ
only depends on the norms of the initial datum, $$\tau $$
τ
and the parameters of the system. We then exploit such result to improve the regularity of the global attractor for the dynamical system associated to the problem.
Gradient higher integrability for singular parabolic double-phase systems
Authors: Kim Wontae , Särkiö Lauri 
Published: March 2024

AbstractWe prove a local higher integrability result for the gradient of a weak solution to parabolic double-phase systems ofp-Laplace type when$$\tfrac{2n}{n+2}< p\le 2$$2nn+2<p≤2. The result is based on a reverse Hölder inequality in intrinsic cylinders combiningp-intrinsic and (p, q)-intrinsic geometries. A singular scaling deficits affects the range ofq.
Comparing high-intensity versus moderate-intensity exercise training in coronary artery disease patients: a randomized controlled trial with 6- and 12-month follow-up
Authors: Gonçalves Catarina , Bravo Jorge , Abreu Ana , Pais João , Raimundo Armando 
Published: March 2024

Abstract
Aim
This study aimed to investigate the long-term effects of two exercise-based CR programs on physical activity (PA), sedentary behavior, physical fitness, quality of life (QoL), and mental health in coronary artery disease (CAD) patients.

Subject and methods
Seventy-two CAD participants were randomized (1:1:1) into HIIT, MICT, and control groups. Both training programs spanned 6 weeks with three supervised treadmill exercise sessions per week. MICT targeted ≈70–75% of peak heart rate (HR), while HIIT aimed for ≈85–95% of peak HR. The control group adhered to standard medical recommendations. Assessments at 6- and 12-months post-intervention included body composition, aerobic capacity, muscle strength, PA, SB, QoL, anxiety, and depression.

Results
Over the 6- and 12-month follow-up periods, both exercise groups maintained the levels of aerobic capacity (HIIT ≈ 19.6 ml kg−1 min−1, MICT ≈ 17.8 ml kg−1 min−1), QoL, and PA compared to baseline (p < .001). Symptoms of anxiety and depression remained lower than baseline (p < .001). The HIIT group demonstrated a significant decreasing trend in waist circumference (∆m3−m2% −2 cm, p = .033) compared to MICT (p = .016) and control (p = .001) at 6 months of follow-up. It was maintained at 12 months of follow-up with significant differences to MICT (p = .018) and control (p = .001). In contrast, the control group experienced deteriorations in body composition, SB, symptoms of anxiety, and depression, along with a decline in aerobic capacity over time.

Conclusion
Encouraging CAD patients to maintain elevated PA levels can promote cardiovascular, WC, and mental health. CR exercise programs can reduce cardiovascular risk factors and induce favorable lifestyle changes. Notably, HIIT demonstrated sustained improvements surpassing those of MICT. These findings underscore the importance of structured exercise-based CR programs in optimizing long-term outcomes for CAD patients.

Trial Registration
https://clinicaltrials.gov/ct2/show/NCT03538119 on May 25, 2018.
ISCEV standard for clinical pattern electroretinography (2024 update)
Authors: Thompson D. A. , Bach M. , McAnany J. J. , Šuštar Habjan M. , Viswanathan S. , Robson A. G. 
Published: March 2024

AbstractThe pattern electroretinogram (PERG) is a localized retinal response evoked by a contrast-reversing pattern, usually a black and white checkerboard, which provides information about macular and retinal ganglion cell function. This document, from the International Society for Clinical Electrophysiology of Vision (ISCEV; www.iscev.org) presents an updated and revised Standard for clinical PERG testing. This replaces the 2013 and all earlier versions. Minimum protocols for basic PERG stimuli, recording methods and reporting are specified, to promote consistency of methods for diagnosis and monitoring purposes, while responding to evolving clinical practices and technology. The main changes in the updated ISCEV Standard for clinical PERG include expanded guidance about large stimulus fields, stimulus parameters for simultaneous PERG and pattern visual evoked potential recording, baseline drift correction, and use of consistent ambient room lighting. These changes aim to provide a clinically relevant document about current practice which will facilitate good quality recordings and inter-laboratory comparisons.
Estimating high-density aboveground biomass within a complex tropical grassland using Worldview-3 imagery
Authors: Naicker Rowan , Mutanga Onisimo , Peerbhay Kabir , Odebiri Omosalewa 
Published: March 2024

AbstractA large percentage of native grassland ecosystems have been severely degraded as a result of urbanization and intensive commercial agriculture. Extensive nitrogen-based fertilization regimes are widely used to rehabilitate and boost productivity in these grasslands. As a result, modern management frameworks rely heavily on detailed and accurate information on vegetation condition to monitor the success of these interventions. However, in high-density environments, biomass signal saturation has hampered detailed monitoring of rangeland condition. This issue stems from traditional broad-band vegetation indices (such as NDVI) responding to high levels of photosynthetically active radiation (PAR) absorption by leaf chlorophyll, which affects leaf area index (LAI) sensitivity within densely vegetative regions. Whilst alternate hyperspectral solutions may alleviate the problem to a certain degree, they are often too costly and not readily available within developing regions. To this end, this study evaluated the use of high-resolution Worldview-3 imagery in combination with modified NDVI indices and image manipulation techniques in reducing the effects of biomass signal saturation within a complex tropical grassland. Using the random forest algorithm, several modified NDVI-type indices were developed from all potential dual-band combinations of the Worldview-3 image. Thereafter, linear contrast stretching and histogram equalization were implemented in conjunction with Singular Value Decomposition (SVD) to improve high-density biomass estimation. Results demonstrated that both contrast enhancement techniques, when combined with SVD, improved high-density biomass estimation. However, linear contrast stretching, SVD, and modified NDVI indices developed from the red (630–690 nm), green (510–580 nm), and near-infrared 1 (770–895 nm) bands were found to produce the best biomass predictive model (R2 = 0.71, RMSE = 0.40 kg/m2). The results generated from this research offer a means to alleviate the biomass saturation problem. This framework provides a platform to assist rangeland managers in regionally assessing changes in vegetation condition within high-density grasslands.
The dicot homolog of maize PPR103 carries a C-terminal DYW domain and may have a role in C-to-U editing of some chloroplast RNA transcripts
Authors: McCray Tyra N. , Azim Mohammad F. , Burch-Smith Tessa M. 
Published: March 2024

AbstractIn plants, cytidine-to-uridine (C-to-U) editing is a crucial step in processing mitochondria- and chloroplast-encoded transcripts. This editing requires nuclear-encoded proteins including members of the pentatricopeptide (PPR) family, especially PLS-type proteins carrying the DYW domain. IPI1/emb175/PPR103 is a nuclear gene encoding a PLS-type PPR protein essential for survival in Arabidopsis thaliana and maize. Arabidopsis IPI1 was identified as likely interacting with ISE2, a chloroplast-localized RNA helicase associated with C-to-U RNA editing in Arabidopsis and maize. Notably, while the Arabidopsis and Nicotiana IPI1 orthologs possess complete DYW motifs at their C-termini, the maize homolog, ZmPPR103, lacks this triplet of residues which are essential for editing. In this study we examined the function of IPI1 in chloroplast RNA processing in N. benthamiana to gain insight into the importance of the DYW domain to the function of the EMB175/PPR103/ IPI1 proteins. Structural predictions suggest that evolutionary loss of residues identified as critical for catalyzing C-to-U editing in other members of this class of proteins, were likely to lead to reduced or absent editing activity in the Nicotiana and Arabidopsis IPI1 orthologs. Virus-induced gene silencing of NbIPI1 led to defects in chloroplast ribosomal RNA processing and changes to stability of rpl16 transcripts, revealing conserved function with its maize ortholog. NbIPI1-silenced plants also had defective C-to-U RNA editing in several chloroplast transcripts, a contrast from the finding that maize PPR103 had no role in editing. The results indicate that in addition to its role in transcript stability, NbIPI1 may contribute to C-to-U editing in N. benthamiana chloroplasts.
Indirect interactions involving the PsbM or PsbT subunits and the PsbO, PsbU and PsbV proteins stabilize assembly and activity of Photosystem II in Synechocystis sp. PCC 6803
Authors: Arshad Faiza , Eaton-Rye Julian J. 
Published: March 2024

AbstractThe low-molecular-weight PsbM and PsbT proteins of Photosystem II (PS II) are both located at the monomer-monomer interface of the mature PS II dimer. Since the extrinsic proteins are associated with the final step of assembly of an active PS II monomer and, in the case of PsbO, are known to impact the stability of the PS II dimer, we have investigated the potential cooperativity between the PsbM and PsbT subunits and the PsbO, PsbU and PsbV extrinsic proteins. Blue-native polyacrylamide electrophoresis and western blotting detected stable PS II monomers in the ∆PsbM:∆PsbO and ∆PsbT:∆PsbO mutants that retained sufficient oxygen-evolving activity to support reduced photoautotrophic growth. In contrast, the ∆PsbM:∆PsbU and ∆PsbT:∆PsbU mutants assembled dimeric PS II at levels comparable to wild type and supported photoautotrophic growth at rates similar to those obtained with the corresponding ∆PsbM and ∆PsbT cells. Removal of PsbV was more detrimental than removal of PsbO. Only limited levels of dimeric PS II were observed in the ∆PsbM:∆PsbV mutant and the overall reduced level of assembled PS II in this mutant resulted in diminished rates of photoautotrophic growth and PS II activity below those obtained in the ∆PsbM:∆PsbO and ∆PsbT:∆PsbO strains. In addition, the ∆PsbT:∆PsbV mutant did not assemble active PS II centers although inactive monomers could be detected. The inability of the ∆PsbT:∆PsbV mutant to grow photoautotrophically, or to evolve oxygen, suggested a stable oxygen-evolving complex could not assemble in this mutant.
Treatment strategy for early-stage esophageal cancer
Authors: Sakanaka Katsuyuki 
Published: March 2024

AbstractApproximately 90% of esophageal cancers in Japan are squamous cell carcinomas, and they are often detected at earlier stages in Japan than in Western countries; superficial esophageal cancer without lymph node or distant metastasis comprises one-third of all esophageal cancers in Japan. Endoscopic resection is a minimally invasive treatment for superficial esophageal cancer; however, the risk of regional lymph node recurrence is negligible when it invades the submucosal layer or lymphovasculature. In such cases, surgical treatment is necessary to control regional lymph node recurrences, although the physical burdens and potential complications cannot be overlooked. Recently, clinical trials in Japan have shown promising clinical outcomes of organ preservation strategies. One strategy is initially performing endoscopic resection for superficial esophageal cancer, assessing the risk of lymph node metastasis based on pathological diagnosis for endoscopically resected specimens, and subsequently considering additional therapy (e.g., observation or prophylactic chemoradiotherapy)—another strategy aimed to cure superficial esophageal cancer through definitive chemoradiotherapy alone. The safety and efficacy of the two strategies have been evaluated in clinical trials, which showed that both organ preservation strategies are comparable to surgery in terms of overall survival. However, challenges include improving the accuracy of pretreatment endoscopic diagnosis and decreasing the local–regional recurrence after chemoradiotherapy. This review provides an overview of the latest standard treatment for early-stage esophageal cancer and its future perspectives.
MiR206 and 423-3p Are Differently Modulated in Fast and Slow-Progressing Amyotrophic Lateral Sclerosis Patients
Authors: Musarò Antonio , Dobrowolny Gabriella , Cambieri Chiara , Libonati Laura , Moret Federica , Casola Irene , Laurenzi Gaia , Garibaldi Matteo , Inghilleri Maurizio , Ceccanti Marco 
Published: March 2024

AbstractAmyotrophic lateral sclerosis (ALS) is a rare neuromuscular disease with a wide disease progression. Despite several efforts to develop efficient biomarkers, many concerns about the available ones still need to be addressed. MicroRNA (miR) are non-coding RNAs that can modulate molecular circuits and are involved in ALS pathogenic mechanisms. 22 fast and 23 slow-progressing-defined ALS patients were recruited. ALSFRS-R, strength, respiratory function, nerve conduction studies, and creatine kinase were evaluated at the baseline and after 6 months of follow-up. The mean monthly reduction of the previous variables (progression index – PI) was calculated. MiR206, 133a-3p, 151a-5p, 199a-5p, and 423-3p were dosed. The univariate analysis showed an independent reduction of miR206 and an increase of miR423-3p in patients with a slow slope of ALSFRS-R and weakness, respectively. MiR206 and 423-3p are differently modulated in fast and slow-progressing ALS patients, suggesting a role for microRNAs in prognosis and therapeutic target.
Abelian and consta-Abelian polyadic codes over affine algebras with a finite commutative chain coefficient ring
Authors: Yılmazgüç Gülsüm Gözde , de la Cruz Javier , Martínez-Moro Edgar 
Published: March 2024

AbstractThis paper studies Abelian and consta-Abelian polyadic codes over rings defined as affine algebras over chain rings. For this purpose, we use the classical construction via splittings and multipliers of the underlying Abelian group. We also derive some results on the structure of the associated polyadic codes and the number of codes under these conditions.