bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Development of Electron‐Transporting Conjugated Oligomers Based on Fluorination Reactions and Their Application to Organic Field‐Effect Transistors
Authors: Ie Yutaka , Aso Yoshio 
Published: October 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Polysaccharide Nanocrystal Reinforced Nanocomposites.
Authors: Dufresne Alain 
Published: October 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Poly(hydroxyalkanoates): Biorefinery Polymers with a Whole Range of Applications. The Work of Robert H. Marchessault
Authors: Orts William J. , Nobes Geoffrey A. R. , Kawada Jumpei , Nguyen Sophie , Yu Ga‐er , Ravenelle Francois 
Published: October 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Photochemistry of Nitrogen‐Bridged Cyclophanes: 2,11‐Diaza[32]anthracenoparacyclophane and 2,11‐Diaza[32]paracyclophane Systems
Authors: Okamoto Hideki , Yamaji Minoru , Satake Kyosuke 
Published: October 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Nanocrystalline Gold and Gold—Palladium as Effective Catalysts for Selective Oxidation
Authors: Edwards Jennifer , Landon Philip , Carley Albert F. , Herzing Andrew , Watanabe Masashi , Kiely Christopher J. , Hutchings Graham J. 
Published: October 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: 1‐Bromo‐2,5‐pyrrolidinedione
Authors: Inam‐ul‐Haque Inam‐ul‐Haque , Hussain Syed Aamer , Aslam Nishat 
Published: October 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Regenerative Medicine and Stem Cell Based Drug Discovery
Authors: Sakurada Kazuhiro , McDonald Fiona M. , Shimada Fumiki 
Published: October 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Modelling Room Temperature Ionic Liquids
Authors: Bhargava B. L. , Balasubramanian Sundaram , Klein Michael L. 
Published: October 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Nanostructure Formation Enhances the Activity of LPS‐Neutralizing Peptides
Authors: Mas‐Moruno Carlos , Cascales Laura , Cruz Luis J. , Mora Puig , Pérez‐Payá Enrique , Albericio Fernando 
Published: October 2008

AbstractPeptides that interact with lipopolysaccharide (LPS) can provide the basis for the development of new antisepsis agents. In this work, several LPS‐neutralizing acyl peptides derived from LALF, BPI, and SAP were prepared, structurally characterized, and biologically evaluated. In all cases, peptides with long acyl chains showed greater LPS‐neutralizing activities than the original acetylated peptides. Structural analysis of these peptides revealed that N‐acylation with long acyl chains promotes the formation of micellar or fibril‐like nanostructures, thus proving a correlation between anti‐LPS activity and nanostructure formation. The results of this study provide useful structural insight for the future design of new acyl peptides that strongly bind LPS and therefore act as antisepsis drugs. Furthermore, this nanostructure–biological activity correlation can be translated into other therapeutic areas.
Pretransplantation positron emission tomography scan is the main predictor of autologous stem cell transplantation outcome in aggressive B‐cell non‐Hodgkin lymphoma
Authors: Derenzini Enrico , Musuraca Gerardo , Fanti Stefano , Stefoni Vittorio , Tani Monica , Alinari Lapo , Venturini Filippo , Gandolfi Letizia , Baccarani Michele , Zinzani Pier Luigi 
Published: October 2008

AbstractBACKGROUND.Limited data exist about the role of second‐line chemotherapy response assessed by positron emission tomography (PET) as a prognostic factor in patients with aggressive non‐Hodgkin Lymphoma (NHL) who undergo autologous stem cell transplantation (ASCT). The objective of this analysis was to investigate the main determinants of prognosis in patients with aggressive B‐cell NHL who undergo ASCT, focusing on the impact of pretransplantation PET, secondary age‐adjusted International Prognostic Index (sAA‐IPI) score, histology, and previous response to first‐line chemotherapy.METHODS.Seventy‐five patients with diffuse, large B‐cell lymphoma or grade 3 follicular lymphoma who were treated at the author' institution with second‐line chemotherapy (combined ifosfamide, etoposide, and epirubicin [IEV]) followed by ASCT between September 2002 and September 2006 were included. All patients were evaluated by PET after 1 to 3 courses of IEV chemotherapy before ASCT, and all patients received a conditioning regimen of combined carmustine, etoposide, cytosine arabinoside, and melphalan. The prognostic impact of pretransplantation PET, sAA‐IPI score, histology, and previous response to first‐line chemotherapy was evaluated by univariate and multivariate analyses.RESULTS.Seventy‐two of 75 patients underwent ASCT. In a univariate analysis for progression‐free survival (PFS) and overall survival (OS), a significant association was observed with pretransplantation PET (PFS,P< .00001; OS,P< .01) and previous first‐line response (PFS,P= .02; OS,P= .04). In the multivariate framework, pretransplantation PET was identified as the only independent prognostic factor (PFS,P< .001; OS,P= .01).CONCLUSIONS.The current data indicated that pretransplantation PET is the main prognostic predictor in patients with aggressive B‐cell NHL who are scheduled for ASCT. Cancer 2008. © 2008 American Cancer Society.
Association of PTEN gene methylation with genetic alterations in the phosphatidylinositol 3‐kinase/AKT signaling pathway in thyroid tumors
Authors: Hou Peng , Ji Meiju , Xing Mingzhao 
Published: October 2008

AbstractBACKGROUND.The phosphatidylinositol 3‐kinase (PI3K)/AKT pathway plays an important role in thyroid tumorigenesis and progression. Genetic alterations, particularly PIK3CA amplification and mutations and ras mutations, are the major cause of aberrant activation of this pathway in thyroid tumors. Epigenetic silencing of the PTEN gene, a negative regulator of the PI3K/AKT pathway, also occurs in thyroid tumors, but its relationship with genetic alterations in this pathway is unclear.METHODS.By using quantitative methylation‐specific polymerase chain reaction, the authors examined PTEN methylation and its relationship with genetic alterations in the PI3K/AKT pathway in various types of thyroid tumors.RESULTS.The authors found PTEN methylation to become progressively higher from benign thyroid adenoma to follicular thyroid cancer and to aggressive anaplastic thyroid cancer, which harbored activating genetic alterations in the PI3K/AKT pathway correspondingly with a progressively higher prevalence. The association of PTEN methylation was seen with both overall genetic alterations and individual genetic alterations, particularly PIK3CA alterations and ras mutations, in the PI3K/AKT pathway within each of the 3 types of thyroid tumors. In contrast, no such relationship was observed for the tumor suppressor gene RASSF1A.CONCLUSIONS.The authors found an interesting association of PTEN methylation with the activating genetic alterations in the PI3K/AKT pathway in thyroid tumors. This finding is consistent with a model in which aberrant methylation and hence silencing of the PTEN gene, which coexists with activating genetic alterations of the PI3K/AKT pathway, may enhance the signaling of this pathway aberrantly activated by genetic alterations and hence contribute to the progression of thyroid tumors. Cancer 2008. © 2008 American Cancer Society.
Down‐regulation of Bax‐interacting factor‐1 in colorectal adenocarcinoma
Authors: Coppola Domenico , Khalil Farah , Eschrich Steven A. , Boulware David , Yeatman Timothy , Wang Hong‐Gang 
Published: October 2008

AbstractBACKGROUND.Bax‐interacting factor‐1 (Bif‐1) protein is a member of the endophilin B family that plays a critical role in apoptosis, autophagy, and mitochondrial morphology. Loss of Bif‐1 suppresses programmed cell death and promotes tumorigenesis. The connection of Bif‐1 to colorectal cancer remains to be evaluated.METHODS.To determine Bif‐1 expression in human colorectal adenocarcinoma (CRC), the authors performed immunohistochemistry using stage‐oriented cancer tissue microarrays containing 102 CRC samples of different stages and 38 samples of normal colorectal mucosa (NR). Formalin‐fixed, paraffin‐embedded core sections on the tissue array were immunostained using the avidin‐biotin‐peroxidase method and the anti‐Bif‐1 murine monoclonal antibody. Bif‐1 staining was scored by 2 independent observers. To examine Bif‐1 mRNA levels, the authors performed DNA microarray analysis of 205 CRC and 10 NR samples.RESULTS.Bif‐1 expression was negative in 22.5% (23 of 102) of CRCs. Moderate to strong Bif‐1 staining was identified in 36.3% (37 of 102) of the tumors, and weak staining was noted in 41.2% (42 of 102). Twenty‐six of 38 (68.4%) NR samples exhibited moderate to strong Bif‐1 immunoreactivity, and none of them was negative. In 12 (31.6%) cases NR demonstrated weak Bif‐1 stain. The mean (median) scores for CRCs and NR differed significantly: 3.2 (3.0) and 5.2 (6.0), respectively (P = .0003). The percentage of cases with negative expression also differed significantly between NR and CRC (P = .002). Decreased Bif‐1 expression in CRCs was confirmed at the mRNA level by microarray analysis.CONCLUSIONS.The authors report the down‐regulation of Bif‐1 during the transition from NR to CRC, a novel finding in agreement with the tumor suppressor function of Bif‐1. Cancer 2008. © 2008 American Cancer Society.
Expression of the embryonic lethal abnormal vision‐like protein HuR in human mesothelioma
Authors: Stoppoloni Daniela , Cardillo Irene , Verdina Alessandra , Vincenzi Bruno , Menegozzo Simona , Santini Mario , Sacchi Ada , Baldi Alfonso , Galati Rossella 
Published: October 2008

AbstractBACKGROUND.The human embryonic lethal abnormal vision (ELAV)‐like protein HuR is a messenger RNA (mRNA)‐binding protein that controls the stability of certain transcripts, including cyclooxygenase2 (COX‐2).METHODS.To investigate a possible contribution of dysregulation of mRNA stability to the progression of cancer and to COX‐2 over expression in mesothelioma, the authors studied expression of COX‐2 and HuR in 5 mesothelioma cell lines (MSTO, NCI, Ist‐Mes1, Ist‐Mes2, and MPP89) and in a group of 29 human mesothelioma specimens that were characterized previously for COX‐2 expression.RESULTS.All 5 cell lines expressed HuR, whereas COX‐2 was not detectable in MSTO or NCI cells. Treatment with cytokines induced a shift in systolic HuR protein levels in MPP89 and Ist‐Mes2 cells that was accompanied by an increase in the expression of COX‐2 mRNA and protein. In Ist‐Mes1 cells, cytokine stimulation did not cause the passage of HuR from nucleus to cytoplasm, and the synthesis of COX‐2 did not increase. In tumor tissues, immunohistochemistry revealed a positive, statistically significant correlation between high COX‐2 expression and cytoplasmic localization of HuR (P = .016). Moreover, on univariate analysis, overall survival was found to be influenced strongly by cytoplasmic HuR localization (P = .004).CONCLUSIONS.The current results suggested that HuR plays a role in tumor progression in mesothelioma and that COX‐2 may be a target of its activity in neoplastic cells. Together, these observations indicate that strategies aiming toward the modulation of HuR may have a potential clinical benefit in mesothelioma. Cancer 2008. © 2008 American Cancer Society.
Health care utilization by adult Hispanic long‐term survivors of hematopoietic stem cell transplantation
Authors: Prasad Pinki K. , Sun Can‐Lan , Baker K. Scott , Francisco Liton , Forman Stephen , Bhatia Smita , Shankar Sadhna M. 
Published: October 2008

AbstractBACKGROUND.Long‐term hematopoietic cell transplantation (HCT) survivors have a high prevalence of severe and chronic health conditions, placing significant demands on the healthcare system. The objective of the current study was to evaluate and compare the healthcare utilization by adult Hispanic and non‐Hispanic white long‐term survivors of HCT.METHODS.A mailed questionnaire was used to assess self‐reported healthcare utilization in 3 domains: general contact with healthcare system, general physical examination outside cancer center (GPE), and cancer/HCT center visit. Eligible individuals had undergone HCT between 1974 and 1998, at age ≥21 years, and had survived ≥2 years after HCT.RESULTS.The cohort included 681 non‐Hispanic white and 137 Hispanic survivors. The median age at HCT was 38.3 years, and the median length of follow‐up was 6.6 years. Hispanic survivors had lower family income and education and were more likely to lack health insurance. The prevalence of GPE increased significantly over time among non‐Hispanic whites (67% at 2‐5 years to 76% at 11+ years) but remained unchanged among Hispanics (66% to 61%). Cancer/HCT center visits declined over time among both Hispanics and non‐Hispanic whites, but a higher proportion of Hispanics reported cancer/HCT center visits at 11+ years after HCT (81% vs 54%).CONCLUSIONS.Compared with non‐Hispanic whites, Hispanic survivors are less likely to establish contact with primary care providers years after HCT and to continue to receive care at cancer/HCT centers. Future studies of this population are needed to establish the factors responsible for this pattern of healthcare utilization. Cancer 2008. © 2008 American Cancer Society.
Sites of distant recurrence and clinical outcomes in patients with metastatic triple‐negative breast cancer
Authors: Lin Nancy U. , Claus Elizabeth , Sohl Jessica , Razzak Abdul R. , Arnaout Amal , Winer Eric P. 
Published: October 2008

AbstractBACKGROUND.The purpose of the current study was to characterize the outcomes of patients with metastatic triple‐negative breast cancers, including the risk and clinical consequences of central nervous system (CNS) recurrence.METHODS.Using pharmacy and pathology records, a study group of 116 patients who were treated for metastatic triple‐negative breast cancer at Dana‐Farber Cancer Institute between January 2000 and June 2006 was identified.RESULTS.The median survival from time of metastatic diagnosis was 13.3 months. Sixteen patients (14%) were diagnosed with CNS involvement at the time of initial metastatic diagnosis; overall, 46% of patients were diagnosed with CNS metastases before death. The median survival after a diagnosis of CNS metastasis was 4.9 months. The age‐adjusted and race‐adjusted rate of death for patients whose first presentation included a CNS metastasis was 3.4 times (95% confidence interval, 1.9‐6.1 times) that of patients without a CNS lesion at the time of first metastatic presentation. Of the 53 patients who developed brain metastases, only 3 patients were judged to have stable or responsive systemic disease in the face of progressive CNS disease at the last follow‐up before death.CONCLUSIONS.Triple‐negative breast cancer is associated with poor survival after recurrence. CNS recurrence is common, but death as a direct consequence of CNS progression in the setting of controlled systemic disease is uncommon. Thus, it does not appear that the high rate of CNS involvement is because of a sanctuary effect, but rather is due to the lack of effective therapies in general for this aggressive subtype of breast cancer. New treatment strategies are needed. Cancer 2008. © 2008 American Cancer Society.
Head and neck squamous cell carcinoma in 13 patients with Fanconi anemia after hematopoietic stem cell transplantation
Authors: Masserot Caroline , Peffault de Latour Régis , Rocha Vanderson , Leblanc Thierry , Rigolet Arnaud , Pascal Francis , Janin Anne , Soulier Jean , Gluckman Eliane , Socié Gérard 
Published: October 2008

AbstractBACKGROUND.Fanconi anemia (FA) is a chromosomal instability disorder with a very high risk of developing head and neck squamous cell carcinoma (HNSCC), most notably after hematopoietic stem cell transplantation (HSCT).METHODS.In the current study, the authors reported 13 cases of HNSCC in FA patients who underwent HSCT at the Saint Louis Hospital between 1976 and 2007.RESULTS.The median age of the patients at time of HSCT was 9.7 years. All patients received irradiation‐based conditioning before HSCT and all developed extensive chronic graft versus host disease (GVHD). HNSCC was diagnosed at a median interval of 10 years after HSCT, mainly in numerous sites within the oral cavity (11 patients). Lymph node involvement was diagnosed in 4 patients. The TNM classification was: T1 in 6 patients, T2 in 2 patients, T3 in 2 patients, and T4 in 3 patients. Treatment was comprised of surgery in 10 patients, with clear surgical margins reported in 7 (including cervical lymph node dissection in 6 patients). Surgery was performed in addition to other treatments in only 2 patients (radiotherapy or cryotherapy). For the remaining 3 patients, treatment consisted in radiotherapy (2 patients) or chemotherapy (1 patient). Disease progression while receiving therapy was observed in 5 patients and 5 other patients developed disease recurrence between 3.5 and 23.7 months after treatment. Death occurred in 11 patients. At the time of last follow‐up, only 2 patients were alive without any disease between 9 and 23 months after diagnosis.CONCLUSIONS.HNSCC developing in FA patients after HSCT is associated with a very poor prognosis. A systematic surveillance of the oral cavity is essential to permit early surgery, which to the authors' knowledge remains the only curative treatment for a minority of patients. It is very important to attempt to prevent this cancer by reducing chronic GVHD and using conditioning without irradiation. Cancer 2008. © 2008 American Cancer Society.
Downregulation of glial glutamate transporters after dopamine denervation in the striatum of 6‐hydroxydopamine‐lesioned rats
Authors: Chung E.K.Y. , Chen L.W. , Chan Y.S. , Yung K.K.L. 
Published: October 2008

AbstractOveractivity of glutamatergic neurotransmission in the basal ganglia is known to be closely related to the onset and pathogenesis of Parkinson's disease. Glutamate homeostasis around glutamatergic synapses is tightly regulated by two groups of glutamate transporters: glial glutamate transporters GLT1 (EAAT2) and GLAST (EAAT1), and neuronal glutamate transporter EAAC1. In order to investigate the changes of glutamate transporters after the onset of Parkinson's disease, unilateral 6‐hydroxydopamine‐lesioned rat, an animal model of Parkinson's disease, was employed. By immunofluorescence and Western blot analyses, GLT1 and GLAST proteins were significantly reduced in the striatum with lesion. No change in GLT1 and GLAST protein was found in the substantia nigra. The reduction of GLT1 protein in the striatum was more prominent than that of GLAST protein (≈40% vs. 20%). In addition, EAAC1 protein was found to be increased in the substantia nigra pars reticulata of the lesioned rats but not in the striatum. The present results indicate that reductions of GLT1 and GLAST may impair glutamate homeostasis around glutamatergic synapses in the striatum and contribute to over‐spills of glutamate in the system. An increase in the EAAC1 level in the substantia nigra pars reticulata may increase GABA synthesis and enhance GABAergic neurotransmission. These results indicate that there are differential and distinct modulations of glutamate transporters after dopamine denervation in the 6‐hydroxydopamine‐lesioned rat. J. Comp. Neurol. 511:421–437, 2008. © 2008 Wiley‐Liss, Inc.
A comparison of the choice of monoclonal antibodies for recovery of fetal cells from maternal blood using FACS for noninvasive prenatal diagnosis of hemoglobinopathies
Authors: D'Souza Edna , Ghosh Kanjaksha , Colah Roshan 
Published: October 2008

AbstractBackgroundIsolation of adequate numbers of fetal cells circulating in the maternal circulation is the major hurdle in developing noninvasive prenatal diagnostic procedures. We used flow cytometry and a combination of different monoclonal antibodies to compare the yield and purity of the fetal nucleated red blood cells at different periods of gestation.MethodsUsing a Percoll discontinuous gradient, the fetal nucleated erythrocytes were enriched from 7 ml maternal blood. In 100 samples, the enriched cells were stained with CD45, anti‐fetal hemoglobin, and glycophorin A antibodies and in 30 samples they were stained with CD45, anti‐fetal hemoglobin, and CD71 and then sorted and used for fetal diagnosis of hemoglobinopathies.ResultsUsing the first set of antibodies, although we were able to obtain a higher percentage of fetal nucleated red cells (0.07% ± 0.2%) as compared to the second set which yielded comparatively smaller numbers (0.025% ± 0.03%), there was some compromise in purity.ConclusionUsing CD45, anti‐fetal hemoglobin and CD71 would be preferred as minimizing maternal contamination is more important than yield for prenatal diagnosis. © 2008 Clinical Cytometry Society