bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimizing implant positioning in total hip arthroplasty via the direct anterior approach: The role and technique of conventional traction table and fluoroscopy
Authors: Ishii Seiya , Baba Tomonori , Hayashi Koju , Homma Yasuhiro , Muto Osamu , Ishijima Muneaki 
Published: February 2025

Abstract

Background
Precise implant positioning during total hip arthroplasty (THA) is an important factor influencing dislocation rate and long-term implant survival. Although a special carbon fiber traction table for THA improves the accuracy of implant positioning, it is too expensive. We aimed to report the accuracy of cup positioning and complication rate in patients undergoing THA via the direct anterior approach using a conventional noncarbon fiber traction table, which is generally used for osteosynthesis of femoral fractures.

Methods
This retrospective study included 101 patients who received primary THA via the direct anterior approach using a conventional traction table with fluoroscopy between July 2022 and October 2024. Two observers evaluated radiological outcomes using postoperative anteroposterior X-rays. The intraclass correlation coefficients of cup positioning angles were calculated (inclination: 0.92, anteversion: 0.89 for intra-observer agreement; inclination: 0.91, anteversion: 0.85 for inter-observer agreement). Complications were defined as dislocation, periprosthetic fracture, ankle fracture, implant loosening, nerve injury, surgical site infection, deep vein thrombosis, and revision surgery for any reason.

Results
Radiographic analysis showed an average cup inclination of 38.1° ± 4.1° (99.0% within Lewinnek’s safe zone). The average cup anteversion was 12.0° ± 4.7° (97.0% within Lewinnek’s safe zone). None of the patients experienced any complications.

Conclusion
The use of a conventional traction table to perform THA using fluoroscopy may not interfere with precise cup positioning. This technique, which does not require a special carbon fiber traction table for THA, could be a feasible alternative for performing THA at general hospitals.
Assessing the backwater rise of floating barriers with racks for various blockages in open channels
Authors: Zayed Mahmoud , Saleh Mahmoud 
Published: February 2025

Abstract

One major risk in the stream is thought to be debris. The general effects of debris spreading have a detrimental effect on water infrastructure and water activities. A rack (curtain) with float units on top is the component of a floating barrier with a rack that is used in Egypt to trap the stream debris. It is installed upstream of water structures to collect debris and protect such structures from clogging. Units of the steel barrier that float have racks that do not extend or rest to the level of the channel bed. The majority of earlier researches examined the hydraulics of trash racks; however, there is a lack of knowledge involving the hydraulic performance of floating barriers and racks with debris blocking. One hundred experiments were conducted to study the hydraulic performance of such floating barriers in open channels, regarding the effects of discharges, flow depths, and blockage rack ratios which was defined as the rack blocked area relative to the projected area of the rack. The findings show that backwater rise (Δh) increased through the rack with increasing Froude numbers and rack blockage ratio. Whilst, increasing water depth caused a decrease in Δh at a constant blockage ratio of the rack. A new equation is developed with the tested parameters to predict Δh of floating barrier with rack for the range of 0.013 ≤ F

o
≤ 0.077, 0.25 ≤ B

r
≤ 1, and 0.063 ≤ B

c
≤ 0.40. The developed Δh values for the tested limits and flow conditions were considered minor in terms of practical applicability, with Δh ≤ 100 mm in the prototype. Consequently, this type of floating barrier is considered the optimal choice for trapping debris before reaching the body of the structure, serving as a primary line of defense.
Real-World Evidence of Combination Therapy Use in Metastatic Hormone-Sensitive Prostate Cancer in the United States From 2017 to 2023
Authors: Raval Amit D. , Lunacsek Orsolya , Korn Matthew J. , Littleton Natasha , Constantinovici Niculae , George Daniel J. 
Published: February 2025

PURPOSE
Treatment of metastatic hormone-sensitive prostate cancer (mHSPC) has evolved with robust clinical trial evidence on the benefits of combining androgen-deprivation therapy (ADT) with androgen receptor pathway inhibitors (ARPIs; abiraterone, apalutamide, darolutamide, and enzalutamide) and/or docetaxel (DOC). To understand current treatment approaches in clinical practice, we examined combined therapy for mHSPC in US real-world practice.

METHODS
This retrospective study used administrative claims in the Komodo Research Dataset (January 2016-September 2023). Individuals with mHSPC were identified on the basis of their earliest claim for metastasis on/after prostate cancer diagnosis date without evidence of castration resistance. Index date was the earliest ADT claim after mHSPC. Combination therapy included the addition of ARPI, DOC, or both to ADT within 4 months of index date. Multinomial regression was used to examine factors associated with combination therapy.

RESULTS
Study population consisted of 10,717 individuals, with a median age of 65 years and a majority of de novo mHSPC cases at diagnosis (62%). Overall, 28% received combination therapy with ARPI (18% abiraterone; 10% apalutamide, darolutamide, or enzalutamide), 9% with DOC, and 2.5% with ARPI plus DOC. From 2017 to 2023, combined hormonal therapy with ARPI increased from 13% to 47% and with ARPI plus DOC from 0.8% to 15%, whereas use of ADT plus DOC declined from 12% to 3% and ADT alone from 74% to 36%. Key factors associated with combination therapy were younger age, fewer chronic comorbidities, de novo mHSPC, and bone metastases.

CONCLUSION
Although one third of men received ADT alone in 2023, the use of combination hormonal therapy with ARPI and/or DOC increased between 2017 and 2023, highlighting uptake of guideline-recommended treatment, driven by available clinical evidence, disease burden, and tolerability.
Personalized Injury Risk Assessment and Exercise Prescription Based on Tendon Strain
Authors: Mersmann Falk , Bohm Sebastian , Domroes Theresa , Weidlich Kolja , Arampatzis Adamantios 
Published: February 2025

ABSTRACT
Tendon strain determines the mechanical demand on a tendon and regulates the metabolic and structural response. Imbalances of muscle strength and tendon stiffness can substantially change tendon operating strain, affecting the individual consequences of loading. Such imbalances can be identified based on maximum tendon strain during fixed-end contractions, with implications for a personalized assessment of injury risk and exercise prescription.
Habilidades en analítica digital como impulsoras de la investigación innovadora en IA: implicaciones para el desarrollo avanzado de talento
Authors: Corrales Liévano Juan David , Reyes Rojas Juan Carlos 
Published: February 2025

Objetivo: este estudio explora la relación entre el talento en ciencia de datos y la productividad deinvestigación en inteligencia artificial (IA), utilizando datos del Índice Global de IA 2023 para analizarcómo las habilidades en análisis de datos impulsan la innovación en IA. Metodología: a través de unanálisis comparativo en 44 países, se identificaron patrones significativos que subrayan la importanciade las competencias avanzadas en ciencia de datos para el desarrollo y la innovación en IA. Resultados principales: los resultados destacan correlaciones claras entre la disponibilidad de talento en ciencia de datos y la calidad y cantidad de la producción de investigación en IA, lo que sugiere que fortalecer la educación y la formación en ciencia de datos es crucial para avanzar en el progreso tecnológico en este campo. Conclusiones: este artículo no solo proporciona evidencia empírica sobre el impacto del talento en ciencia de datos en la innovación en IA, sino que también ofrece recomendaciones para políticas y prácticas que pueden fomentar un ecosistema de IA más dinámico y productivo.
Unraveling an uncommon encounter: hypokalemic periodic paralysis with Brugada phenocopy amidst hypokalemia
Authors: Dankar Razan , Barakat Salim , El-Charabaty Elie , Hashmi Syed Salman Hamid , El Sayegh Suzanne E. 
Published: February 2025

Introduction: Hypokalemic periodic paralysis (HPP) presents a diagnostic challenge due to the painless muscle weakness it causes. This case discusses a patient with HPP along with electrocardiogram (ECG) findings of Brugada phenocopies (BrP) in the setting of hypokalemia. A review of the literature showed that it is the seventh documented example of BrP induced by hypokalemia alongside HPP. Case description: A 43-year-old man presented to the emergency department with lower limb weakness. He attributed his symptoms to a substantial meal consumed after breaking his Ramadan fast, recalling a similar episode following heavy meals in the past. The patient was alert and oriented but demonstrated reduced strength in both upper and lower limbs. ECG revealed a Brugada type 1 pattern. Laboratory analysis revealed hypokalemia (2.5 mmol/l), elevated creatine kinase (326 U/l), and normal thyroid function. Following potassium supplementation, his symptoms resolved, and his ECG normalized. Discussion: HPP occurs in the context of increased carbohydrate intake, potentially leading to rapid insulin release and activation of Na-K ATPase, enhancing cellular potassium absorption and lowering serum potassium levels. Symptoms range from weakness and fatigue to severe neuromuscular weakness and cardiac arrhythmias. Investigating hypokalemia requires excluding hypomagnesemia, thyroid function tests, and metabolic acidosis/alkalosis before considering HPP. Management involves gradual oral potassium repletion to avoid the risk of hyperkalemia associated with intravenous administration. Conclusion: Clinicians should consider including HPP in differential diagnoses of patients presenting with weakness. In this case, electrophysiological evaluation suggested Brugada pattern induced by hypokalemia, which resolved with potassium supplementation.
Necessidades informacionais sobre autocuidado de crianças com leucemia para criação de aplicativo móvel
Authors: Martins Vanessa Ramos , Góes Fernanda Garcia Bezerra , Silva Aline Cerqueira Santos Santana da , Macedo Eliza Cristina , Silva Laura Johanson da , Silva Liliane Faria da 
Published: February 2025

Objetivo: identificar as necessidades informacionais sobre autocuidado de crianças com leucemia para a criação de aplicativos móveis. Método: pesquisa qualitativa, realizada entre novembro de 2023 e janeiro de 2024 em uma casa de apoio no Rio de Janeiro, Brasil, mediante entrevistas semiestruturadas com dez crianças com leucemia. Dados processados no software IRAMUTEQ® e interpretados por análise temática. Protocolo de pesquisa aprovado pelo comitê de ética em pesquisa. Resultados: identificaram-se cinco temas resultantes do agrupamento interpretativo das sete classes de segmentos de texto relacionadas às necessidades informacionais para o autocuidado: repercussões do tratamento, diagnóstico, quimioterapia, cuidados com o corpo e ambiente domiciliar, além das mídias desejáveis em aplicativos móveis, com destaque para vídeos e jogos. Conclusão: as necessidades informacionais descritas podem facilitar o compartilhamento de orientações de forma atrativa, lúdica e acessível, gerando possíveis contribuições positivas no processo de autocuidado dessas crianças.
Influence of teaching a structured and humanized method of care on the perception of medical student attitudes in the doctor-patient relationship
Authors: Chagas Cardoso Higor , Pereira Edna Regina Silva , Soares Viviane , Rabahi Marcelo Fouad 
Published: February 2025

Introduction
The humanization of care can be defined, in a generic way, as the act of making an empathetic and respectful approach to patients. This study proposed to evaluate the perception of attitudes of medical students regarding the doctor-patient relationship, after implementation of teaching a humanized and structured care method.

Materials and methods
Single-blind, randomized controlled experimental study that evaluated medical students in relation to patient care, based on a pre-post design, using the Patient-Practitioner Orientation Scale (PPOS). This scale has been validated to assess patient-centered attitudes, as the prime outcome measure. The intervention, with a group of randomized students, included teaching the structured and humanized method of patient care, denominated the SEAGULL (Subjective, Exams, Analysis, Goal, Ultimate Action), and was carried out at the university outpatient clinic.

Results
Fifty-nine medical students participated in the study, with a mean age of 21.3 years (SD = 2.8) and a higher prevalence of female students (71.2%). The increase in the final scores was greater in the intervention group (p = 0.025) when comparing means of the total PPOS scores. The intervention group presented a larger effect size and higher mean scores (d = 0.49, Δ = +0.38, p<0.001) than the control group (d = 0.21, Δ = + 0.10, p = 0.004). It is noteworthy that the analysis of the initial and final means of the PPOS scores of the sharing domain revealed larger effect sizes in the intervention group compared to the control group (Δ = +0.42, d = 0.63; p<0.001).

Discussion and conclusion
The findings showed that training in the use of the SEAGULL structured method led to a significant increase in PPOS scores related to the humanization of care by these students, with emphasis on the domain of sharing information, power, and responsibility with patients.
Association between C-reactive protein and chronic pain in US adults: A nationwide cross-sectional study
Authors: Huang Chunsheng , Tong Qizhen , Tong Qiaoling 
Published: February 2025

Background
Chronic pain has emerged as a significant global public health concern. Hence, it is imperative to acquire a more comprehensive comprehension of these characteristics in the adult population of the United States in order to facilitate the development of effective interventions. The objective of this study is to ascertain the prevalence of chronic pain among people in the United States and investigate its association with C-reactive protein (CRP) levels.

Methods
The present study employed a cross-sectional design and utilized data from three cycles of the National Health and Nutrition Examination Survey (NHANES). The study aimed to investigate the relationship between chronic pain status, CRP levels, and potential confounding factors. The study incorporated individuals who successfully fulfilled chronic questionnaires and had CRP assays. Weighted univariate and multivariate logistic regression analyses were performed to examine the correlation between chronic pain and CRP levels. To explore the non-linear relationship, weighted restricted cubic spline (RCS) with three knots coupled with a weighted logistic regression model to assess the dose-response relationship between CRP (continuous variables) and chronic pain.

Results
A total of 10,680 (Weighted 250,814,660.8) adult participants with complete information were included in the analysis and 2612 (Weighted 67978784.88, 27.1%) subjects met the definition of chronic pain. Compared with participants without chronic pain, those with chronic pain had a higher CRP level (P < 0.001). The results of the multivariable adjusted logistic regression model suggested that the highest CRP quartile (CRP >  0.52 mg/dL) was associated with a 32% increase in the risk of chronic pain compared with the lowest CRP quartile (CRP ≤  0.09 mg/dL). The RCS result showed that the OR of chronic pain and CRP displayed a linear relationship (P = 0.027, Non-linear P = 0.541).

Conclusions
The study found a significant correlation between CRP levels and the presence of chronic pain among people in the United States. Individuals exhibiting elevated levels of CRP demonstrated a heightened propensity for experiencing chronic pain in comparison to individuals with lower CRP levels. Additional investigation is necessary to explore the presence of a causal association between the two variables, as well as the potential underlying mechanisms.
Characterization of gene expression profiles in Alzheimer’s disease and osteoarthritis: A bioinformatics study
Authors: Liu Nian , Deng Qian , Peng Zining , Mao Danning , Huang Yuanbo , Meng Fanyu , Zhang Xiaoyu , Shen Jiayan , Li Zhaofu , Yan Weitian , Peng Jiangyun 
Published: February 2025

Background
Alzheimer’s disease (AD) and Osteoarthritis (OA) have been shown to have a close association in previous studies, but the pathogenesis of both diseases are unclear. This study explores the potential common molecular mechanisms between AD and OA through bioinformatics analysis, providing new insights for clinical treatment strategies.

Methods
The AD and OA-related datasets were downloaded from the gene expression database GEO. The datasets were analyzed to obtain differentially expressed gene (DEG) datasets for OA and AD, respectively. The intersection of these DEGs was analyzed to identify common DEGs (Co-DEGs). Subsequently, the Co-DEGs were enriched, and a protein-protein interaction network was constructed to identify core genes. The expression of these genes was validated in a separate dataset, and their diagnostic value for the diseases was analyzed. In addition, the core genes were analyzed using gene set enrichment analysis and single-gene genome variation analysis.

Results
Analysis of DEGs on gene chips from OA and AD patients revealed significant changes in gene expression patterns. Notably, EFEMP2 and TSPO, genes associated with inflammatory responses, showed lower expression levels in both AD and OA patients, suggesting a downregulation in the pathological backgrounds of these diseases. Additionally, GABARAPL1, which is crucial for the maturation of autophagosomes, was found to be upregulated in both conditions. These findings suggest the potential of these genes as diagnostic biomarkers and potential therapeutic targets. However, to confirm the effectiveness of these genes as therapeutic targets, more in-depth mechanistic studies are needed in the future, particularly to explore the feasibility and specific mechanisms of combating disease progression by regulating the expression of these genes.

Conclusions
This study suggests that AD and OA shares common molecular mechanisms. The identification of EFEMP2, GABARAPL1, and TSPO as key target genes highlights potential common factors in both diseases. Further investigation into these findings could lead to new candidate targets and treatment directions for AD and OA, offering promising avenues for developing more effective and targeted therapeutic interventions.
Measles neutralising antibody levels in patients receiving intravenous immunoglobulin treatment – a sub-analysis of a randomized, cross-over bioequivalence trial
Authors: Rajendram Vatsala , Paddick Martyn , More John 
Published: February 2025

Background
Intravenous immunoglobulin is a replacement therapy for patients living with primary immunodeficiencies. Each batch of intravenous immunoglobulin is required by the Food and Drug Administration to contain threshold levels of measles neutralising antibodies. Widespread use of the measles vaccine has decreased measles antibody potency in the United States plasma supply. There is limited data on measles antibody trough levels in treated primary immunodeficiency patients. The aim of this sub-analysis was to evaluate the measles antibody trough levels in treated primary immunodeficiency patients.

Methods
GMX07 was an open-label, two-period, crossover bioequivalence study which randomized 33 adult patients with primary immunodeficiency disease in 16 centres across the United States, the United Kingdom and Hungary. Eligible adult patients received five infusions of Gammaplex® 5% followed by five infusions of Gammaplex® 10%, or vice versa, on either a 21- or 28-day dosing regimen. The trial included 15 paediatric patients who were not randomized, receiving only five infusions of 10% product. This sub-analysis measured trough levels of measles neutralising antibodies using a Vero cell-based measles virus neutralisation assay.

Results
Median measles antibody trough levels were ~ 1300 mIU/mL with no significant difference between Gammaplex 5% and Gammaplex 10% treatment (p >  0.9) or the 21-day or 28-day dosing regimen (p >  0.3). There was also no difference between mean measles neutralising antibody levels following Gammaplex 10% in adult or paediatric patients.

Conclusions
Levels of measles neutralising antibodies in the 5% and 10% formulations of this intravenous immunoglobulin product provided protective antibodies well above accepted thresholds and were similar in adult and paediatric patients across both 21-day and 28-day dosing regimens. Switching between Gammaplex products did not affect antibody levels.

Trial registration
ClinicalTrials.gov NCT01963143
Bruxism repercussions in muscular activation: Ultrasound differences in abdominal wall between women with and without bruxism. A cross-sectional study
Authors: Yela-Lorenzo Paula , Montes-Arenas Paola , Abuín-Porras Vanesa , González-de-la-Flor Ángel , González-Fernández Laura , Villafañe Jorge Hugo , Mínguez-Esteban Isabel 
Published: February 2025

Introduction
Bruxism, often triggered by stress, induces temporomandibular alterations, increasing muscle activity and affecting dental occlusion. Prevalence of musculoskeletal conditions related to stress is higher in women, with craneo-cervical affectation being frequently reported. Moreover, some authors explore the relationship between temporomandibular disorders and postural alteration, affecting the trunk complex. This study aims to evaluate differences in abdominal muscle morphology between women with and without bruxism in Spain, and, secondarily, the effects of voluntary teeth grinding in abdominal muscle activation.

Methodology
An observational analytical cross-sectional study was conducted with 44 Spanish women (diagnosed with bruxism = 22, non-bruxism = 22). To ensure and corroborate the absence of bruxism from the control group, the Clinical Based Assesment questionnaire was used. Ultrasound measures of Transverse Abdominal, External Oblique and Internal oblique were recorded during rest and voluntary grinding.

Results
Grinding was associated with changes in abdominal muscle thickness in both groups, with statistically significant higher thickness values for all studied muscles. Moreover, the Bruxism group showed statistically significant higher values for all muscles in grinding conditions compared to the Non-Bruxism group. Significant differences in left transverse abdominal thickness were found between groups in resting condition. Further analysis using linear regression indicated that both Bruxism (t = -2.03, p = 0.049) and BMI (t = 3.13, p = 0.003) were significantly associated with muscle thickness, with BMI acting as a confounding factor. Age was not a significant predictor (p = 0.506), suggesting its limited role in this context.

Conclusion
The results of this study support the existence of an association between bruxism and the abdominal wall muscles structure and activation. This emphasizes the importance of considering bruxism in the evaluation of abdominal muscle function.