bluuebunny/crossref_metadata_2025_split huggingface dataset:
Detection of Rickettsia raoultii in Vermipsylla alakurt-Like Fleas of Sheep in Northwestern China
Authors: Li Fengshi , Zhao Shanshan , Li Ente , Xie Songsong , Wang Nan , Tan Wenbo , Wang Yuanzhi 
Published: February 2024

Abstract
Introduction
To date, a total of 2574 validated flea species have been discovered. Vermipsyllidae is a family of fleas that comprises at least eight species. Vermipsylla is a genus of the family Vermipsyllidae within the order Siphonaptera of fleas. Here a novel Vermipsylla species was described, and rickettsial agent was also detected in it.

Methods
A total of 128 fleas were collected directly from 260 pastured sheep in China. Of these, eight representative fleas (four males and four females) were identified by key morphological features. Meanwhile, 120 flea DNAs, including six flea samples for molecular taxonomy, were subjected to Rickettsia spp. DNA detection. The molecular identity of fleas was determined by amplification and sequenmce analysis of four genetic markers (the 28S rDNA genes, the 18S rDNA genes, the mitochondrial cytochrome c oxidase subunit I and subunit II). In addition, five Rickettsia-specific gene fragments were used to identify the species of the rickettsial agents. The amplified products were sequenced and phylogenetically analyzed.

Results
The morphological characteristics of the flea species identified in this study were similar to Vermipsylla alakurt, but presented difference in hair number of the metepimeron, the third tergum, the genitals and the tibiae of hind leg. The 18S rDNA, 28S rDNA and COII genetic markers from fleas showed the highest identity to those of V. alakurt, shared 98.45% (954/969), 95.81% (892/931) and 85.86% (571/665) similarities, respectively. However, the COI sequence showed the highest identity to that of Dorcadia ioffi with 88.48% (576/651) similarity. Rickettsia raoutii tested positive in 14.17% (17/120) flea DNA samples.

Conclusion
Our study reports the detection of R. raoultii in V. alakurt-like fleas infesting sheep in China.
Approximation of multistage stochastic programming problems by smoothed quantization
Authors: Šmíd Martin , Kozmík Václav 
Published: February 2024

AbstractWe present an approximation technique for solving multistage stochastic programming problems with an underlying Markov stochastic process. This process is approximated by a discrete skeleton process, which is consequently smoothed down by means of the original unconditional distribution. Approximated in this way, the problem is solvable by means of Markov Stochastic Dual Dynamic Programming. We state an upper bound for the nested distance between the exact process and its approximation and discuss its convergence in the one-dimensional case. We further propose an adjustment of the approximation, which guarantees that the approximate problem is bounded. Finally, we apply our technique to a real-life production-emission trading problem and demonstrate the performance of its approximation given the “true” distribution of the random parameters.
The impact of social changes on MICE tourism management in the age of digitalization: a bibliometric review
Authors: Martín-Rojo Inmaculada , Gaspar-González Ana Isabel 
Published: February 2024

AbstractThe meetings, incentives, conferences, and Exhibitions (MICE) tourism has intensively grown in recent decades. The MICE sector has also been strongly affected by social and technological changes, especially new social habits resulting from the COVID-19 pandemic. Our research maps the state of the art in MICE tourism and its digitalization from 1997 (first published article found on the subject) to 2022, as well as the changes brought about by COVID-19 to the management of MICE tourism. To identify the main changes caused by COVID-19 pandemic in MICE tourism management, we carried out a survey based on surveys with Conference managers, Exhibition and Trade Fair Centers, and Convention Bureaus in Spain, a leading country in MICE tourism worldwide. For this purpose, we carried out a survey based on surveys with managers of Conference, Exhibition and Trade Fair Centers and Convention Bureaus in Spain, a leading country in MICE tourism worldwide, to identify the main changes that the COVID-19 pandemic has caused in the management of this type of tourism. Based on the results obtained, a bibliometric analysis was carried out using the software SciMAT to find out the thematic evolution of the terms MICE tourism, digital and Business Tourism. This study identifies the most significant topics in MICE tourism management during the pre-pandemic period (1997–2019), the pandemic, and post-pandemic period (2020–2022). We also analyzed the most cited concepts during 1997–2019, as well as their evolution towards other concepts in 2020–2022. Considering the results obtained, future lines of research related to innovation, digitalization, social networks, and destination analysis are proposed for a better and more competitive management of this tourism activity.
The Natural History and Risk Factors for the Development of Food Allergies in Children and Adults
Authors: Lee Eric C. K. , Trogen Brit , Brady Kathryn , Ford Lara S. , Wang Julie 
Published: February 2024

Abstract
Purpose of Review
This narrative review explores food allergy prevalence and natural history stratified by life stages, especially in context of evolving knowledge over the last few decades.

Recent Findings
The prevalence of food allergy remains highest in early childhood with common food triggers being cow’s milk, soy, hen’s egg, wheat, peanut, tree nuts, sesame, fish, and shellfish. This correlates with certain risk factors especially pertinent in the postnatal period which appear to predispose an individual to developing a food allergy. Some allergies (such as milk and egg) were previously thought to be easily outgrown in early life; however, recent studies suggest increasing rates of persistence of these allergies into young adulthood; the reason behind this is unknown. Despite this, there is also evidence demonstrating that food allergies can be outgrown in adolescents and adults.

Summary
An understanding of the paradigm shifts in the natural history of food allergy allows clinicians to provide updated, age-appropriate, and tailored advice for patients on the management and prognosis of food allergy.
The Clinical Reality of Granulomatous Prostatitis
Authors: Hanssen A. , Vrij C. , Heesakkers J. 
Published: February 2024

Abstract
Purpose of Review
Granulomatous prostatitis is a rare inflammatory disease of the prostate. It is challenging for the clinician because it mimics prostate cancer and cannot be distinguished from prostate cancer clinically, biochemically, or radiologically. Granulomatous prostatitis can only be diagnosed by histopathological examination. To prevent overdiagnosis and overtreatment, it is an important disease to recognize.

Recent Findings
There are multiple case reports and studies describing granulomatous prostatitis.

Summary
This review aims to give an overview regarding the epidemiology, etiology, clinical presentation, diagnosis, and treatment of granulomatous prostatitis using (recent) literature.
Smart home technology adoption in Denmark: Diffusion, social differences, and energy consumption
Authors: Hansen Anders Rhiger , Trotta Gianluca , Gram-Hanssen Kirsten 
Published: February 2024

AbstractSmart home technology (SHT) is increasingly entering homes to provide services such as energy management, security, comfort, and convenience. However, research shows that adoption varies across social groups and that SHT might affect energy demand. Denmark is considered a frontrunner in the uptake of SHT and offers a unique opportunity to combine administrative household information with energy consumption data and survey responses on SHT uptake. This paper studies a representative sample of 1,468 Danish households to investigate SHT diffusion, social differences in SHT adoption, and correlations between SHT and energy consumption, divided into appliance use and heating. The results indicate that entertainment and home security are the most popular SHT services in Denmark and that SHT is more widespread among younger households, especially for entertainment and robotic help. In contrast, smart heating systems are more widespread among older households. Living in a detached house seems to increase the likelihood of having SHT, while the highest income group appears more likely to have security systems, and technical education seems associated with the adoption of SHT for heating management. Finally, smart security systems were associated with higher electricity consumption, and SHT for electricity management was associated with higher heating consumption and to a lesser extent higher electricity consumption, but there was no significant correlation between having smart heating control and heating consumption.
Mindfulness-based empathy training supported by Obese Simulation Suit: Randomized Controlled Trial
Authors: Can Gür Ganime , Yılmaz Emine 
Published: February 2024

AbstractNursing serves as the foundation of patient-centered healthcare services, and the empathetic connections formed between nurses and patients are integral to delivering quality care. In this context, the mental well-being and empathy levels of nurses significantly impact the efficiency of healthcare services and patient contentment. This study investigates the impact of mindfulness-based empathy training and obese simulation suits on nursing students' attitudes and empathy levels towards obese patients. The research, conducted as a randomized controlled trial, encompassed 84 nursing students and employed the "Attitude Scale Towards Obese Patients," "Jefferson Empathy Scale for Nursing Students," and "Descriptive Information Form." Data analysis involved two-factor ANOVA for mixed measurements. The study revealed significant interaction effects between group and time concerning nursing students' attitudes towards obese individuals [F(1,70) = 43.281, p < 0.05] as well as their empathy levels towards obese individuals [F(1,70) = 15.657, p < 0.05]. The experimental group exhibited a noteworthy increase in both attitudes and empathy levels compared to the control group. Furthermore, Single Factor ANOVA for Repeated Measures revealed a statistically significant difference in the experimental group's attitudes and empathy scores across pretest, posttest, and follow-up assessments [p < 0.01, partial η2 = 0.492 and 0.186, respectively]. These findings underscore the effectiveness of these interventions in enhancing essential nursing competencies necessary for providing comprehensive patient care. Thus, integrating these methods into the curriculum is recommended to cultivate more positive attitudes and heightened empathy among nursing students, particularly concerning obese patients, throughout their educational journey.
Shattered hierarchy: how the Gaza conflict demolished Maslow’s pyramid of needs
Authors: Abed Alah Muna 
Published: February 2024

AbstractConflicts and wars have a profound impact on human needs, as vividly illustrated by the ongoing crisis in Gaza. This paper aims to systematically examine how these crises affect individuals’ ability to meet their basic and higher-order needs, as conceptualized by Maslow’s hierarchy. By employing Maslow’s framework, this paper seeks to uncover the specific ways in which conflict disrupts the fulfillment of essential human needs and to identify targeted interventions that can mitigate these effects. Through this focused lens, I hope to contribute to a deeper understanding that supports efforts to end the war. In this paper, a methodical approach that integrates a review of online news, media reports, published official reports from international organizations, and academic publications was adopted to identify the current challenges in Gaza impacting the different levels of need. An exploration through the framework of Maslow’s hierarchy revealed the extensive humanitarian challenges stemming from the blockade and military actions since 2008. There are significant disruptions across all levels of Maslow’s hierarchy. Despite the severe compromise in basic needs like safety and physiological sustenance, there is a notable resilience in the pursuit of transcendence needs among the residents by transcending personal suffering through acts of solidarity, altruism, and community engagement and exhibiting a deeper sense of spirituality and faith that provide solace and a sense of connection to a larger purpose. There is an urgent need to end the conflict, facilitate unrestricted aid, and address the multifaceted needs of Gaza’s population. Strategies that support both immediate survival and long-term personal and communal growth in the face of adversity are critically needed. Essential initiatives include establishing community support networks for critical needs like food, shelter, and healthcare, alongside promoting economic stability through livelihood projects. Additionally, the development of online education programs offering vocational training and digital literacy, in partnership with international institutions, is crucial. These initiatives, tailored to Gaza’s context and aimed at overcoming siege-related barriers, are vital for empowering residents with the skills for community rebuilding, economic self-sufficiency, and enhanced social cohesion. Such strategies are indispensable for addressing immediate adversities while laying a foundation for sustainable future growth.
Dactylorhiza maculata agg. (Orchidaceae) in Central Europe: Intricate Patterns in Morphological Variability, Cytotype Diversity and Ecology Support the Single-Species Concept
Authors: Taraška Vojtěch , Duchoslav Martin , Hroneš Michal , Batoušek Petr , Lamla František , Temsch Eva M. , Weiss-Schneeweiss Hanna , Trávníček Bohumil 
Published: February 2024

AbstractEffective protection of endangered species is often limited by taxonomic discrepancies across state borders. This is also the case of the Dactylorhiza maculata agg. in Central Europe, where one to three species and several infraspecific taxa are recognized in various countries. Based on an extensive analysis of morphological variation, ploidy levels, environmental traits and habitats of 64 populations in Central Europe and adjacent regions, we aimed to propose a unified taxonomic concept applicable throughout the study area. Multivariate analysis of morphological traits revealed continuous variation at the individual level and only minor differences between particular clusters of populations. Four DNA-ploidy levels were detected using flow cytometry. Diploids (2n = 40) and tetraploids (2n = 80) were the most abundant and usually formed single-cytotype populations whereas DNA-triploids and DNA-hexaploids occurred only sporadically as minority cytotypes. The inferred patterns of morphological and ploidy variation were not congruent with traditional taxonomic treatment regarding diploid D. fuchsii and tetraploid D. maculata as two species with several infraspecific taxa. Instead, all taxa analysed in the current study are best treated at the subspecies level within D. maculata s. lat. due to somewhat continuous morphological variation between morphotypes. A total of eight D. maculata subspecies may be recognized in Central Europe, of which one is newly described here as D. maculata subsp. arcana, subsp. nov. Some nomenclatural riddles have been resolved, and the threat status of the recognized taxa is discussed.
Causal Conditionals, Tendency Causal Claims and Statistical Relevance
Authors: Sikorski Michał , van Dongen Noah , Sprenger Jan 
Published: February 2024

AbstractIndicative conditionals and tendency causal claims are closely related (e.g., Frosch and Byrne, 2012), but despite these connections, they are usually studied separately. A unifying framework could consist in their dependence on probabilistic factors such as high conditional probability and statistical relevance (e.g., Adams, 1975; Eells, 1991; Douven, 2008, 2015). This paper presents a comparative empirical study on differences between judgments on tendency causal claims and indicative conditionals, how these judgments are driven by probabilistic factors, and how these factors differ in their predictive power for both causal and conditional claims.
Multi-omics Integrative Analysis for Incomplete Data Using Weighted p-Value Adjustment Approaches
Authors: Zhang Wenda , Ma Zichen , Ho Yen-Yi , Yang Shuyi , Habiger Joshua , Huang Hsin-Hsiung , Huang Yufei 
Published: February 2024

AbstractThe advancements in high-throughput technologies provide exciting opportunities to obtain multi-omics data from the same individuals in a biomedical study, and joint analyses of data from multiple sources offer many benefits. However, the occurrence of missing values is an inevitable issue in multi-omics data because measurements such as mRNA gene expression levels often require invasive tissue sampling from patients. Common approaches for addressing missing measurements include analyses based on observations with complete data or multiple imputation methods. In this paper, we propose a novel integrative multi-omics analytical framework based on p-value weight adjustment in order to incorporate observations with incomplete data into the analysis. By splitting the data into a complete set with full information and an incomplete set with missing measurements, we introduce mechanisms to derive weights and weight-adjusted p-values from the two sets. Through simulation analyses, we demonstrate that the proposed framework achieves considerable statistical power gains compared to a complete case analysis or multiple imputation approaches. We illustrate the implementation of our proposed framework in a study of preterm infant birth weights by a joint analysis of DNA methylation, mRNA, and the phenotypic outcome. Supplementary materials accompanying this paper appear online.
The prognostic significance of right paratracheal lymph node dissection numbers in right upper lobe non-small cell lung cancer
Authors: Zhuang FengNian , Lin JunPeng , Chen WeiJie , Chen XiaoFeng , Chen YuJie , Wang PeiYuan , Wang Feng , Liu ShuoYan 
Published: February 2024

Abstract
Background
The number of dissected lymph nodes is closely related to the prognosis of patients with non-small cell lung cancer. This study explored the optimal number of right paratracheal lymph nodes dissected in right upper non-small cell lung cancer patients and its impact on prognosis.

Methods
Patients who underwent radical surgery for right upper lobe cancer between 2012 and 2017 were retrospectively enrolled. The optimal number of right paratracheal lymph nodes and the relationship between the number of dissected right paratracheal lymph nodes and the prognosis of right upper non-small cell lung cancer were analysed.

Results
A total of 241 patients were included. The optimal number of dissected right paratracheal lymph nodes was 6. The data were divided according to the number of dissected right paratracheal lymph nodes into groups RPLND + (≥ 6) and RPLND- (< 6). In the stage II and III patients, the 5-year overall survival rates were 39.0% and 48.2%, respectively (P = 0.033), and the 5-year recurrence-free survival rates were 32.8% and 41.8%, respectively (P = 0.043). Univariate and multivariate analyses revealed that among the stage II and III patients, ≥ 6 right paratracheal dissected lymph nodes was an independent prognostic factor for overall survival (HR = 0.53 95% CI 0.30–0.92 P = 0.025) and recurrence-free survival (HR = 1.94 95% CI 1.16–3.24 P = 0.011).

Conclusions
Resection of 6 or more right paratracheal lymph nodes may be associated with an improved prognosis in patients with right upper non-small cell lung cancer, especially in patients with stage II or III disease.
Chrono-tailored drug delivery systems: recent advances and future directions
Authors: Butler Christine T. , Rodgers Aoife M. , Curtis Annie M. , Donnelly Ryan F. 
Published: February 2024

AbstractCircadian rhythms influence a range of biological processes within the body, with the central clock or suprachiasmatic nucleus (SCN) in the brain synchronising peripheral clocks around the body. These clocks are regulated by external cues, the most influential being the light/dark cycle, in order to synchronise with the external day. Chrono-tailored or circadian drug delivery systems (DDS) aim to optimise drug delivery by releasing drugs at specific times of day to align with circadian rhythms within the body. Although this approach is still relatively new, it has the potential to enhance drug efficacy, minimise side effects, and improve patient compliance. Chrono-tailored DDS have been explored and implemented in various conditions, including asthma, hypertension, and cancer. This review aims to introduce the biology of circadian rhythms and provide an overview of the current research on chrono-tailored DDS, with a particular focus on immunological applications and vaccination. Finally, we draw on some of the key challenges which need to be overcome for chrono-tailored DDS before they can be translated to more widespread use in clinical practice.
Graphical Abstract
Defining the term watershed to reflect modern uses and functions as inter- and intra-connected socio-hydrologic systems
Authors: Meierdiercks Katherine L. , Finewood Michael H. , Bennett Christianna 
Published: February 2024

AbstractDespite the many programs focused on watershed education, the watershed concept is poorly understood, which can lead to a number of wide-ranging consequences from poor watershed planning and policy to inaccurate scientific studies. We argue that the definition of the term watershed, and the images that accompany the definition, contribute to these misunderstandings. The definition has remained very much the same since it was first documented in Europe in the mid-18th century. However, watershed uses and functions have evolved considerably in the past three centuries, notably in the many ways water moves within and across traditionally-defined watershed boundaries. In this study, content analyses of the definitions of the term watershed from textbooks and online sources, and the accompanying images, highlight that watersheds are nearly universally defined as an area of land that drains to a point on a river. More than half the images that accompany these definitions depict forested landscapes or high mountain relief. While over one half of online images depict human activities or developed landscapes, few textbook images do. These incomplete definitions and idealized images do not reflect the diversity of landscapes and watershed functions. The narrow description can contribute to an individual’s disconnection to their own watershed. Furthermore, the description of watersheds as lumped areas, rather than inter- and intra-connected socio-hydrologic systems, misses a fundamental element of the watershed concept: that activities at every point in a watershed impact all points downstream and are impacted by activities at all points upstream. Thus, we propose a revised definition of a watershed that better captures this connectivity: a watershed defines the boundaries of a system of hydrologically connected people, places, and things.
Hormoontherapie voor prostaatkanker: gevolgen voor de botgezondheid
Authors: Oddens Jorg R. , van Oostwaard Marsha 
Published: February 2024

SamenvattingDe behandeling van prostaatkanker door androgeendeprivatietherapie (ADT) veroorzaakt als neveneffect een afname van de botdichtheid. Voor voorschrijvers van deze medicatie is kennis van het voorkomen van osteoporose en fractuurrisico van belang, en ook kennis van de indicatie voor het doen van vervolgonderzoek en van de indicaties voor aanvullende leefstijladviezen en therapie. In dit artikel bespreken we het verband van ADT met osteoporose en het fractuurrisico, en geven we aanbevelingen op basis van de Nederlandse Richtlijn Prostaatcarcinoom en de onlangs gepubliceerde Nederlandse Richtlijn Osteoporose en fractuurpreventie.