bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patterns of Sleep Duration and Metabolic Biomarkers Across the Menstrual Cycle
Authors: Dunietz Galit Levi , Shedden Kerby , Lyu Xiru , Chervin Ronald D , Baylin Ana , O’Brien Louise M , Jansen Erica C , Wactawski-Wende Jean , Schisterman Enrique F , Mumford Sunni L 
Published: March 2024

Abstract

Context
Along the menstrual cycle, associations between inconsistent sleep duration and levels of metabolic biomarkers are uncertain and could involve fluctuations in estrogen concentrations.

Objective
To examine associations between patterns of sleep duration and metabolic biomarkers across 2 menstrual cycles within a cohort of premenopausal women.

Methods
The BioCycle Study was conducted in New York between 2005 and 2007, enrolling 259 premenopausal women over 2 menstrual cycles. This microlongitudinal cohort study involved intensive data collection including daily sleep diaries and biomarker assessments of leptin, insulin, and glucose at 16 key points timed to menstrual cycle phases. We considered dynamic sleep duration as hours slept 1 night or as mean hours slept during the 2 nights before each biomarker assessment. Variability in habitual sleep duration (ie, reported daily sleep duration) was summarized across both menstrual cycles. Variation in habitual sleep duration was computed using L-moments, a robust version of dispersion, skewness, and kurtosis. To examine associations between patterns of sleep duration and metabolic biomarkers, we fitted a series of linear mixed models with random intercepts and inverse probability weighting. These models were adjusted for potential demographic, lifestyle, health confounders, and menstrual cycle phase.

Results
Sleep duration 1 night or 2 nights before clinic visits were not associated with metabolic biomarker measures. However, overall variability (dispersion) in habitual sleep duration was associated with lower mean insulin Homeostatic Model Assessment for Insulin Resistance levels, but not glucose. Moreover, extremely short or long bouts of sleep duration were associated with higher mean levels of leptin, insulin, and Homeostatic Model Assessment for Insulin Resistance.

Conclusion
These data suggest that variation in habitual sleep duration along the menstrual cycle may be associated with metabolic function.
Stop, in the Name of COVID! Using Social Media Data to Estimate the Effects of COVID-19-Related Travel Restrictions on Migration
Authors: Klein Jordan D. , Weber Ingmar , Zagheni Emilio 
Published: March 2024

Abstract
In the wake of the COVID-19 pandemic, the International Organization for Migration has postulated that international migrant stocks fell short of their pre-pandemic projections by nearly 2 million as a result of travel restrictions. However, this decline is not testable with migration data from traditional sources. Key migration stakeholders have called for using data from alternative sources, including social media, to fill these gaps. Building on previous work using social media data to analyze migration responses to external shocks, we test the hypothesis that COVID-related travel restrictions reduced migrant stock relative to expected migration without such restrictions using estimates of migrants drawn from Facebook's advertising platform and dynamic panel models. We focus on four key origin countries in North and West Africa (Côte d'Ivoire, Algeria, Morocco, and Senegal) and on their 23 key destination countries. Between February and June 2020, we estimate that a destination country implementing a month-long total entry ban on arrivals from Côte d'Ivoire, Algeria, Morocco, or Senegal might have expected a 3.39% reduction in migrant stock from the restricted country compared with the counterfactual in which no travel restrictions were implemented. However, when broader societal disruptions of the pandemic are accounted for, we estimate that countries implementing travel restrictions might paradoxically have expected an increase in migrant stock. In this context, travel restrictions do not appear to have effectively curbed migration and could have resulted in outcomes opposite their intended effects.
Images of Mediterranean Crossing
Authors: Whitley Leila 
Published: March 2024

Abstract
What do photographs of small boats crossing the Mediterranean construct as they circulate as privileged signifiers of the 2015 “migrant crisis”? While it is sometimes assumed that these images mobilize sympathy and, perhaps, intervention, this article queries how one such image has circulated and constructed notions of crisis in ways that center Europe and Europeans while passing over migrants. The analysis is grounded in a close engagement with Massimo Sestini's widely reproduced photograph Rescue Operation, selected for its status as a privileged signifier of this crisis. The article first examines how the photograph circulated in the mainstream press, showing how the image is made to stand for general conditions, while those who appear in the image are displaced from the stories the photograph is used to tell. It then shows how contextual and representational choices that shaped the image, and what was obscured from it, are structural to how it comes to depict “rescue” as a limited frame centering European intervention. The article argues that this photograph and its receptions work to reduce images of migrants to evidence for tales of European response and rescue.
The Checkpoint of History: Testimony and Intertextuality in the Documentary Literature of the Korean War, 1960s–1970s
Authors: Ryan Thomas M. 
Published: March 2024

Abstract
Korean War literature has historically encompassed a wide range of ideologically disparate texts. If canonical works of literary fiction have critically interrogated the violence of war and division, the civil war itself has continued to generate institutionalized cultural production purporting to document the crimes of the other side. Working against the categorical separation of these two traditions, this article explores their mutual and intertextual constitution. The sponsorship and commercialization of North Korean defector memoirs (kwisunja sugi) in 1960s South Korea, the article shows, influenced the development of two other popular genres of Korean War literature that alternately reinforced and undermined statist anticommunism. First, the novelist Yi Pyŏngju (1921–1992) employed kwisunja sugi as historical records in his works of the 1960s and 1970s, even as he demonstrated an awareness of the historicity and duplicity of Cold War testimony. Second, while autobiographical essays (ch’ehŏm sugi) submitted to the amateur nonfiction contest (1965–80) of the monthly Sin tonga mimicked kwisunja sugi, charting their authors’ immersion in and escape from the scene of communist violence, these texts also applied this structure to subaltern life in the militarized, capitalist South, reaffirming subversive understandings of the Korean Civil War as a reciprocal system.
Distinct features of the regenerating heart uncovered through comparative single-cell profiling
Authors: Carey Clayton M. , Hollins Hailey L. , Schmid Alexis V. , Gagnon James A. 
Published: March 2024

ABSTRACT
Adult humans respond to heart injury by forming a permanent scar, yet other vertebrates are capable of robust and complete cardiac regeneration. Despite progress towards characterizing the mechanisms of cardiac regeneration in fish and amphibians, the large evolutionary gulf between mammals and regenerating vertebrates complicates deciphering which cellular and molecular features truly enable regeneration. To better define these features, we compared cardiac injury responses in zebrafish and medaka, two fish species that share similar heart anatomy and common teleost ancestry but differ in regenerative capability. We used single-cell transcriptional profiling to create a time-resolved comparative cell atlas of injury responses in all major cardiac cell types across both species. With this approach, we identified several key features that distinguish cardiac injury response in the non-regenerating medaka heart. By comparing immune responses to injury, we found altered cell recruitment and a distinct pro-inflammatory gene program in medaka leukocytes, and an absence of the injury-induced interferon response seen in zebrafish. In addition, we found a lack of pro-regenerative signals, including nrg1 and retinoic acid, from medaka endothelial and epicardial cells. Finally, we identified alterations in the myocardial structure in medaka, where they lack primordial layer cardiomyocytes and fail to employ a cardioprotective gene program shared by regenerating vertebrates. Our findings reveal notable variation in injury response across nearly all major cardiac cell types in zebrafish and medaka, demonstrating how evolutionary divergence influences the hidden cellular features underpinning regenerative potential in these seemingly similar vertebrates.
Impact of 18FFDG-PET/CT and Laparoscopy in Staging of Locally Advanced Gastric Cancer: A Cost Analysis in the Prospective Multicenter PLASTIC-Study
Authors: de Jongh Cas , van der Meulen Miriam P. , Gertsen Emma C. , Brenkman Hylke J. F. , van Sandick Johanna W. , van Berge Henegouwen Mark I. , Gisbertz Suzanne S. , Luyer Misha D. P. , Nieuwenhuijzen Grard A. P. , van Lanschot Jan J. B. , Lagarde Sjoerd M. , Wijnhoven Bas P. L. , de Steur Wobbe O. , Hartgrink Henk H. , Stoot Jan H. M. B. , Hulsewe Karel W. E. , Spillenaar Bilgen Ernst Jan , van Det Marc J. , Kouwenhoven Ewout A. , Daams Freek , van der Peet Donald L. , van Grieken Nicole C. T. , Heisterkamp Joos , van Etten Boudewijn , van den Berg Jan-Willem , Pierie Jean-Pierre , Eker Hasan H. , Thijssen Annemieke Y. , Belt Eric J. T. , van Duijvendijk Peter , Wassenaar Eelco , Wevers Kevin P. , Hol Lieke , Wessels Frank J. , Haj Mohammad Nadia , Frederix Geert W. J. , van Hillegersberg Richard , Siersema Peter D. , Vegt Erik , Ruurda Jelle P. ,   the PLASTIC Study Group
Published: March 2024

Abstract
Background
Unnecessary D2-gastrectomy and associated costs can be prevented after detecting non-curable gastric cancer, but impact of staging on treatment costs is unclear. This study determined the cost impact of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18FFDG-PET/CT) and staging laparoscopy (SL) in gastric cancer staging.

Materials and Methods
In this cost analysis, four staging strategies were modeled in a decision tree: (1) 18FFDG-PET/CT first, then SL, (2) SL only, (3) 18FFDG-PET/CT only, and (4) neither SL nor 18FFDG-PET/CT. Costs were assessed on the basis of the prospective PLASTIC-study, which evaluated adding 18FFDG-PET/CT and SL to staging advanced gastric cancer (cT3–4 and/or cN+) in 18 Dutch hospitals. The Dutch Healthcare Authority provided 18FFDG-PET/CT unit costs. SL unit costs were calculated bottom-up. Gastrectomy-associated costs were collected with hospital claim data until 30 days postoperatively. Uncertainty was assessed in a probabilistic sensitivity analysis (1000 iterations).

Results
18FFDG-PET/CT costs were €1104 including biopsy/cytology. Bottom-up calculations totaled €1537 per SL. D2-gastrectomy costs were €19,308. Total costs per patient were €18,137 for strategy 1, €17,079 for strategy 2, and €19,805 for strategy 3. If all patients undergo gastrectomy, total costs were €18,959 per patient (strategy 4). Performing SL only reduced costs by €1880 per patient. Adding 18FFDG-PET/CT to SL increased costs by €1058 per patient; IQR €870–1253 in the sensitivity analysis.

Conclusions
For advanced gastric cancer, performing SL resulted in substantial cost savings by reducing unnecessary gastrectomies. In contrast, routine 18FFDG-PET/CT increased costs without substantially reducing unnecessary gastrectomies, and is not recommended due to limited impact with major costs.
Trial registration: NCT03208621. This trial was registered prospectively on 30-06-2017.
THE EFFECT OF DEXTRANAL ON THE GUT BACTERIOBIOME OF CALVES
Authors: Naumova Natalia B. , Baturina Olga A. , Lokteva Anna S. , Pleshakova Valentina I. , Lescheva Nadezhda A. , Lorengel Tatiana I. , Zolotova Natalia S. , Alekseeva Irina G. , Kabilov Marsel R. 
Published: March 2024

Background. The search for more efficient pro- and prebiotics to improve calves’ health, including decreasing the incidence of intestinal infections and increasing biomass production, has been very actual. The effect of prebiotics, however, is poorly, especially as related to gut microbiome biodiversity.
The aim of this work was to study the influence of dextranal on the growth of calves and their gut(rectum) bacteriobiome.
Materials and Methods. Bacteriobiome composition and structure was assessed in the control group (K, conventional diet) and dextranal-receiving group (D) in 18-20 days aged calves by 16S metabarcoding (V3-V4, Illumina MiSeq).
Results. Overall, we found 377 operational taxonomic units (OTU) from 168 genera, 91 families, 55 orders, 30 classes and 11 phyla, with more than the half of the total number of identifies OTUs belonging to the Firmicutes phylum, followed by Bacteroidetes and Actinobacteria. The relative abundance of the phylum-specific nucleotide sequences followed the same order of dominance. Dextranal addition resulted in the increased (11.9 kg/calf, or 15%) of the living body mass of the two-months old calves in group D as compared with group K: consequently, the dextranal-related difference in the calves’ gut bacteriobiome composition and structure can be viewed as beneficial. It primarily concerns the decreased abundance of the opportunistic pathogen Escherichia/Shigella (Gammaproteobacteria) in group D. Overall 73 OTUs, including six dominant ones, were found to be differentially abundant in the groups. However, changes in the relative abundance of some OTUs were difficult to interpret, most likely due to the low strain/species resolution by 16S rRNA gene fragments’ sequences. As for the α- biodiversity, there were no differences between the groups, but the overall trend directed to the increasing α- biodiversity of the calves’ gut bacteriobiome after dextranal treatment.
Conclusion. This study reports the first attempt to inventory the gut bacteriobiome of the cattle in the region, and the obtained results provide the basis for a more detailed and taxonomically targeted further research.
FEATURES OF CYTOKINE PRODUCTION DURING REHABILITATION AFTER COVID-19 IN PEOPLE LIVING IN THE NORTHERN REGIONS OF SIBERIA
Authors: Belenyuk Vasilii D. , Sinyakov Alexander A. , Shavrina Ekaterina O. , Moskalenko Olga L. 
Published: March 2024

The coronavirus infection of 2019 (COVID-19) has significantly affected the modern world. Recently, it has been proven that IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IFN-γ and TNF-α play an important role in the inflammatory response of the body to SARS-CoV-2 infection.
Purpose. To study the features of the synthesis of key cytokines in residents of the Turukhansky district of the Krasnoyarsk Territory who underwent COVID-19.
Materials and methods. On the basis of "Turukhanskaya RB", village. Turukhansk, in February 2023, 98 patients were examined, the average age was 58 (± 5 years). Of the 98 participants interviewed, 76 people had an official diagnosis of COVID-19 in the period from October 2020. The study was conducted with the permission of the ethical committee of the Research Institute of Medical Problems of the North. Each participant signed an informed consent form for the examination, according to the Helsinki Declaration of the World Medical Association regulating the conduct of scientific research.
Results. A high IgG titer to SARS-Cov-2 was observed in 99% of the examined, a positive IdM titer to SARS-Cov-2 was in 1% of the examined. In the course of studying the features of the cytokine network in patients with Turukhansk there was a significant decrease in the concentration of α-TNF, IL-1b and IL-10, as well as an increase in IL-2, IL-6 and IL-8 relative to the control group of Krasnoyarsk. α-IFN and IL-4 showed no significant changes and remained within the control range. At the same time, no differences were found between the groups of patients with a confirmed diagnosis of COVID-19 and without it.
Conclusion. The data obtained indicate a high level of homogeneity of the sample in the village . Turukhansk, regardless of the presence of the disease, about the low level of detection and control over the course of COVID-19. We observe the formation of a chronic inflammatory process against the background of the prevalence of pro-inflammatory function and an increase in the concentration of pro-inflammatory cytokines, which can subsequently deplete the body's resources and contribute to the development of additional complications.
CLINICAL AND LABORATORY FEATURES OF THE IMMUNE RESPONSE IN CHILDREN WITH COVID-19 INFECTION
Authors: Ageeva Elizaveta S. , Rymarenko Natalya V. , Dyadyura Elena N. , Gurtovaya Anna K. , Safronyuk Sergey L. , Ablaeva Remzie N. , Usova Svetlana V. 
Published: March 2024

The article presents the results of the analysis of clinical and morphological characteristics and a number of indicators of peripheral blood in children with a new coronavirus infection.
The purpose of the study is to give clinical and laboratory characteristics of the immune response in children with a new coronavirus infection.
Materials and methods. 102 children with a new coronavirus infection were examined. Evaluation of peripheral blood parameters and lymphocyte subpopulations in children of three age groups 0-4 years, 5-9 years and 10-14 years.
Results. In children with a new coronavirus infection, an imbalance of the granulocytic and lymphocytic link is observed, which is most pronounced for children of the younger (0-4 years) and middle (5-9 years) age groups. The general trend of changes is characterized by an increase in lymphocytes and granulocytes at the onset of the disease and a decrease after 2 weeks. The ratio of neutrophils to lymphocytes shows the predominance of neutrophils.
Conclusion. The established changes are characterized as specific for most viral infections, but at the same time reflect the pathogenetic specifics of SARS-CoV-2 infection, as a combination of age-related features of the functioning of the immune system and the etiotropic effect of the virus.
PHYSICAL EUSTRESSORS AS POTENTIAL TOOLS TO IMPROVE CROP STRESS TOLERANCE (REVIEW)
Authors: Bakhchevnikov Oleg N. , Braginets Sergey V. , Kravchenko Nina S. , Pakhomov Viktor I. 
Published: March 2024

Background. The processes occurring in plants and their seeds under stress, as well as the defense mechanisms used by plants under stress, are poorly understood, which makes it impossible to use them to increase yields.
Purpose. Review and analysis of scientific publications, devoted to the phenomenon of stress memory acquired by plants as a result of physical stressors on their seeds and possible applications of this phenomenon in plant growing and crop breeding.
Materials and methods. A selection and systematic review of scientific articles on the research topic for the period 2016-2023 was performed. The study consisted of the following steps: research literature search, evaluation and selection, data synthesis and analysis.
Results. The use of hormetic effects of physical agents to stimulate seed germination of crops is effective. Responses to abiotic stresses could be 'trained' by priming so that the plant becomes better able to cope with later stress. Evidence of short-term and transgenerational memory formation following plant priming has been obtained. An epigenetic mechanism for the formation of long-term stress memory in plants as a result of a physical eustressor has been identified. The eustressor induces specific epigenetic marks associated with environmental adaptation, forming a new stress-resistant plant phenotype. Physical eustressors have the potential to impart stress tolerance to crops to enhance phenotypic characteristics to prevent yield losses.
Conclusion. Seed treatment with physical stressors builds plant tolerance and memory to abiotic stresses, but scientific evidence on this issue is incomplete and sketchy. The understanding and application of stress memory for breeding purposes is currently limited, but it has great potential for the development of new crop varieties.
Metabolic accompaniment of plasma lipoproteins profile in persons with maladaptation
Authors: Tsymbryla Volodymyr , Barylyak Liliya , Żukow Xawery , Popovych Igor 
Published: March 2024

Background. During the implementation of the project "The relationship between the lipoprotein profile of the blood plasma and the parameters of the neuroendocrine-immune complex, and the influence of the factors of the Truskavets’ spa on them", we first divided observed cohort into 5 homogeneous groups that differed from each other by 6 discriminant variables. The purpose of this study is to identify the metabolic accompaniment of plasma lipoprotein profile in the same persons.
Material and research methods. The object of observation were 41 volunteers: 20 women aged 30-76 years and 21 men aged 24-69 years without clinical diagnose but with dysfunction of neuroendocrine-immune complex and dysmetabolism. We estimated lipoprotein profile of plasma, determined the levels of the proinflammatory cytokines, parameters of lipid peroxidation as well as routine biochemical and paraclinical parameters.
Results. The patients with increased, normal and decreased levels of Dobiásová’s&Frohlich’s Atherogenic Index of Plasma (D&FAIP) are characterized, together with levels of Triglycerides and HDLP Cholesterol by definition, by specific constellations of levels of IL-6, IL-1, Diene conjugates, Malondialdehyde, Katalase, Glucose, and Alanine aminotransferase (classification accuracy is 98.8%). A close canonical correlation was found between the parameters of the plasma lipoprotein profile, on the one hand, and metabolism and erythroon, on the other (R=0.920).
Conclusion. Atherogenic, normal and anti-atherogenic blood plasma is characterized by specific levels of markers of inflammation, lipid peroxidation, cytolysis and erythroon.
Factors influencing Frey syndrome after parotidectomy with acellular dermal matrix
Authors: Chai Xian-Da , Jiang Huan , Tang Ling-Ling , Zhang Jing , Yue Long-Fei 
Published: March 2024

BACKGROUND
Frey syndrome, also known as ototemporal nerve syndrome or gustatory sweating syndrome, is one of the most common complications of parotid gland surgery. This condition is characterized by abnormal sensations in the facial skin accompanied by episodes of flushing and sweating triggered by cognitive processes, visual stimuli, or eating.
AIM
To investigate the preventive effect of acellular dermal matrix (ADM) on Frey syndrome after parotid tumor resection and analyzed the effects of Frey syndrome across various surgical methods and other factors involved in parotid tumor resection.
METHODS
Retrospective data from 82 patients were analyzed to assess the correlation between sex, age, resection sample size, operation time, operation mode, ADM usage, and occurrence of postoperative Frey syndrome.
RESULTS
Among the 82 patients, the incidence of Frey syndrome was 56.1%. There were no significant differences in sex, age, or operation time between the two groups (P > 0.05). However, there was a significant difference between ADM implantation and occurrence of Frey syndrome (P < 0.05). ADM application could reduce the variation in the incidence of Frey syndrome across different operation modes.
CONCLUSION
ADM can effectively prevent Frey syndrome and delay its onset.