bluuebunny/crossref_metadata_2025_split huggingface dataset:
Qohélet vi 1-2: « Dieu ne permet pas … »
Authors: Maussion Marie 
Published: November 2005

AbstractQohelet vi 1-2, rather difficult to understand, tells the story of a man who can not use his belongings, although he wants to. A general first reading helps us to relate this text to other ones about the free work (work without benefits), and underlines its place in the book, just beside the fourth chorus about the happiness. A second reading shows us two key words used by Qohelet : the « glory » which suggests that there is more than the work, and the fact that God does not « allow » the man to enjoy his belongings. Consequently, one is able to find some explanations using the opposition between luxurious pleasure and honest joy.
Semantic and Perceptual Representations of Color: Evidence of a Shared Color-Naming Function
Authors: Sayim Bilge , Jameson Kimberly A. , Alvarado Nancy , Szeszel Monika 
Published: November 2005

AbstractMuch research on color representation and categorization has assumed that relations among color terms can be proxies for relations among color percepts. We test this assumption by comparing the mapping of color words with color appearances among different observer groups performing cognitive tasks: (1) an invariance of naming task; and (2) triad similarity judgments of color term and color appearance stimuli within and across color categories. Observer subgroups were defined by perceptual phenotype and photopigment opsin genotype analyses. Results suggest that individuals rely on at least two different representational models of color experience: one lexical, conforming to the culture's normative linguistic representation, and another individual perceptual representation organizing each observer's color sensation experiences. Additional observer subgroup analyses suggest that perceptual phenotype variation within a language group may play a greater role in the shared color naming system than previously thought. A reexamination of color naming data in view of these findings may reveal influences on color naming important to current theories.
Culture and Cognition: What is Universal about the Representation of Color Experience?
Authors: Jameson Kimberly 
Published: November 2005

AbstractExisting research in color naming and categorization primarily reflects two opposing views: A Cultural Relativist view that posits color perception is greatly shaped by culturally specific language associations and perceptual learning, and a Universalist view that emphasizes panhuman shared color processing as the basis for color naming similarities within and across cultures. Recent empirical evidence finds color processing differs both within and across cultures. This divergent color processing raises new questions about the sources of previously observed cultural coherence and cross-cultural universality. The present article evaluates the relevance of individual variation on the mainstream model of color naming. It also presents an alternate view that specifies how color naming and categorization is shaped by both panhuman cognitive universals and socio-cultural evolutionary processes. This alternative view, expressed, in part, using an Interpoint Distance Model of color categorization, is compatible with new empirical results showing divergent color processing within and across cultures. It suggests that universalities in color naming and categorization may naturally arise across cultures because color language and color categories primarily reflect culturally modal linguistic mappings, and categories are shaped by universal cognitive constructs and culturally salient features of color. Thus, a shared cultural representation of color based on widely shared cognitive dimensions may be the proper foundation for universalities of color naming and categorization. Across cultures this form of representation may result from convergent responses to similar pressures on color lexicon evolution.
Focal Color Variability and Unique Hue Stimulus Variability
Authors: Kuehni Rolf 
Published: November 2005

AbstractThe degree to which physiology and culture have affected the formation of primitive color categories continues to be a matter of discussion. In this paper the degree of agreement between the ranges of individual color term foci for the four hue-based color categories yellow, green, blue, and red and individual choices of Munsell samples representing for the observers Hering's four unique hues is investigated. The color term focus range data are extracted from the survey results of the 110 unwritten languages of the World Color Survey, also in terms of the Munsell color order system. Agreement of approximately 90% between the two has been found, indicating the likelihood of a strong color vision system related physiological component in the formation of these four primitive hue categories.
Unique Hue Stimulus Choice: A Constraint on Hue Category Formation
Authors: Kuehni Rolf 
Published: November 2005

AbstractBerlin & Kay hue-related basic color categories are compared with the ISCC-NBS system of object color categorization. Though independently derived, categories of the former form a small subset of the latter. A conjecture is proposed that explains the absence of yellow-green and blue-green basic hue categories and the potential for a violet category as the result of constraints on primitive hue category formation due to considerable variation in stimuli selected by color-normal observers as representing for them unique hues.
Face Value: The Phenomenology of Physiognomy
Authors: Cloonan Thomas 
Published: November 2005

AbstractThe concern of this article is to establish the difference between physiognomy and expression as it may be understood phenomenologically. The work of Merleau-Ponty founds the phenomenological appreciation of physiognomy, and Gestalt psychological studies on perceptual organization elaborate the specifics of physiognomic structure despite the naturalist assumptions of that school of psychology. Physiognomy is the organized structural specification of expression in the phenomenon that presents itself. This view is an alternative to conventional topical but nonthematic considerations on physiognomy (e.g., "face value," visual inspection, physiognomy in language perception, and facial expressiveness). Art therapy with its use of various media is a venue in which the physiognomy of clients' art products is a display of integralness or pathology. It is an immediate access to the world of the patient. The work of the Gestalt psychologist Rudolf Arnheim and of the art therapist Mala Betensky are associated with the phenomenology of Merleau-Ponty in order to advance understanding of the significance of physiognomy in experience, in behavior, and in art therapy.
Brain, Sex and Ideology
Authors: Vidal Catherine 
Published: November 2005

Does a sexual brain exist? There is no simple answer to this question. Indeed, the brain is the origin of thoughts and that makes it different from any other organ. As such, it is both a biological and a cultural organ. Lying behind the original question is the debate between nature and culture. And in this debate, science and ideology are closely linked (Vidal and Benoit-Browaeys, 2005). The topic of brain and sex is a perfect example of this: it concerns everybody and the media love the matter. This can be seen in the following headlines, which appeared recently in the press:‘Science proves that men and women think differently’ (International Herald Tribune, March 1995)‘If I'm stupid, it's mummy's fault’ (le Figaro, June 1997)‘Are homosexuals born that way?’ (Nouvel Observateur, October 1995)‘Why do men never listen, why can't women read a map?’ (A. B. Pease, First Edition, 1999)
Resurrection Research From 1975 to the Present: What are Critical Scholars Saying?
Authors: Habermas Gary 
Published: November 2005

AbstractAn overview of resurrection research in Europe and North America during the last 30 years indicates some expected as well as some surprising trends. This study highlights six of these major research areas. The works of two representative scholars, J.D. Crossan and N.T. Wright, provide interpretive angles on these subjects. The article concludes with some comments on what is taken to be the single most crucial development at present, that after Jesus' death his followers had experiences that they thought were appearances of the risen Jesus. These early Christian experiences need to be explained viably.
Inhaled tolafentrine reverses pulmonary vascular remodeling via inhibition of smooth muscle cell migration
Authors: Pullamsetti Soni , Krick Stefanie , Yilmaz Hüseyin , Ghofrani Ardeschir Hossein , Schudt Christian , Weissmann Norbert , Fuchs Beate , Seeger Werner , Grimminger Friedrich , Schermuly Ralph Theo 
Published: November 2005

AbstractBackgroundThe aim of the study was to assess the chronic effects of combined phosphodiesterase 3/4 inhibitor tolafentrine, administered by inhalation, during monocrotaline-induced pulmonary arterial hypertension (PAH) in rats.MethodsCD rats were given a single subcutaneous injection of monocrotaline to induce PAH. Four weeks after, rats were subjected to inhalation of tolafentrine or sham nebulization in an unrestrained, whole body aerosol exposure system. In these animals (i) the acute pulmonary vasodilatory efficacy of inhaled tolafentrine (ii) the anti-remodeling effect of long-term inhalation of tolafentrine (iii) the effects of tolafentrine on the expression profile of 96 genes encoding cell adhesion and extracellular matrix regulation were examined. In addition, the inhibitory effect of tolafentrine on ex vivo isolated pulmonary artery SMC cell migration was also investigated.ResultsMonocrotaline injection provoked severe PAH (right ventricular systolic pressure increased from 25.9 ± 4.0 to 68.9 ± 3.2 after 4 weeks and 74.9 ± 5.1 mmHg after 6 weeks), cardiac output depression and right heart hypertrophy. The media thickness of the pulmonary arteries and the proportion of muscularization of small precapillary resistance vessels increased dramatically, and the migratory response of ex-vivo isolated pulmonary artery smooth muscle cells (PASMC) was increased. Micro-arrays and subsequent confirmation with real time PCR demonstrated upregulation of several extracellular matrix regulation and adhesion genes, such as matrixmetalloproteases (MMP) 2, 8, 9, 10, 11, 12, 20, Icam, Itgax, Plat and serpinb2. When chronically nebulized from day 28 to 42 (12 daily aerosol maneuvers), after full establishment of severe pulmonary hypertension, tolafentrine reversed about 60% of all hemodynamic abnormalities, right heart hypertrophy and monocrotaline-induced structural lung vascular changes, including the proportion of pulmonary artery muscularization. The upregulation of extracellular matrix regulation and adhesion genes was reduced by nearly 80% by inhalation of the tolafentrine. When assessed in vitro, tolafentrine blocked the enhanced PASMC migratory response.ConclusionIn conclusion, we demonstrate for the first time that inhalation of combined PDE3/4 inhibitor reverses pulmonary hypertension fully developed in response to monocrotaline in rats. This "reverse-remodeling" effect includes structural changes in the lung vascular wall and key molecular pathways of matrix regulation, concomitant with 60% normalization of hemodynamics.
The crucial role of particle surface reactivity in respirable quartz-induced reactive oxygen/nitrogen species formation and APE/Ref-1 induction in rat lung
Authors: Albrecht Catrin , Knaapen Ad M , Becker Andrea , Höhr Doris , Haberzettl Petra , van Schooten Frederik J , Borm Paul JA , Schins Roel PF 
Published: November 2005

Abstract
Persistent inflammation and associated excessive oxidative stress have been crucially implicated in quartz-induced pulmonary diseases, including fibrosis and cancer. We have investigated the significance of the particle surface reactivity of respirable quartz dust in relation to the in vivo generation of reactive oxygen and nitrogen species (ROS/RNS) and the associated induction of oxidative stress responses in the lung. Therefore, rats were intratracheally instilled with 2 mg quartz (DQ12) or quartz whose surface was modified by either polyvinylpyridine-N-oxide (PVNO) or aluminium lactate (AL). Seven days after instillation, the bronchoalveolar lavage fluid (BALF) was analysed for markers of inflammation (total/differential cell counts), levels of pulmonary oxidants (H2O2, nitrite), antioxidant status (trolox equivalent antioxidant capacity), as well as for markers of lung tissue damage, e.g. total protein, lactate dehydrogenase and alkaline phosphatase. Lung homogenates as well as sections were investigated regarding the induction of the oxidative DNA-lesion/oxidative stress marker 8-hydroxy-2'-deoxyguanosine (8-OHdG) using HPLC/ECD analysis and immunohistochemistry, respectively. Homogenates and sections were also investigated for the expression of the bifunctional apurinic/apyrimidinic endonuclease/redox factor-1 (APE/Ref-1) by Western blotting and immunohistochemistry. Significantly increased levels of H2O2 and nitrite were observed in rats treated with non-coated quartz, when compared to rats that were treated with either saline or the surface-modified quartz preparations. In the BALF, there was a strong correlation between the number of macrophages and ROS, as well as total cells and RNS. Although enhanced oxidant generation in non-coated DQ12-treated rats was paralleled with an increased total antioxidant capacity in the BALF, these animals also showed significantly enhanced lung tissue damage. Remarkably however, elevated ROS levels were not associated with an increase in 8-OHdG, whereas the lung tissue expression of APE/Ref-1 protein was clearly up-regulated. The present data provide further in vivo evidence for the crucial role of particle surface properties in quartz dust-induced ROS/RNS generation by recruited inflammatory phagocytes. Our results also demonstrate that quartz dust can fail to show steady-state enhanced oxidative DNA damage in the respiratory tract, in conditions were it elicits a marked and persistent inflammation with associated generation of ROS/RNS, and indicate that this may relate to compensatory induction of APE/Ref-1 mediated base excision repair.
Selecting additional tag SNPs for tolerating missing data in genotyping
Authors: Huang Yao-Ting , Zhang Kui , Chen Ting , Chao Kun-Mao 
Published: November 2005

Abstract
Background
Recent studies have shown that the patterns of linkage disequilibrium observed in human populations have a block-like structure, and a small subset of SNPs (called tag SNPs) is sufficient to distinguish each pair of haplotype patterns in the block. In reality, some tag SNPs may be missing, and we may fail to distinguish two distinct haplotypes due to the ambiguity caused by missing data.

Results
We show there exists a subset of SNPs (referred to as robust tag SNPs) which can still distinguish all distinct haplotypes even when some SNPs are missing. The problem of finding minimum robust tag SNPs is shown to be NP-hard. To find robust tag SNPs efficiently, we propose two greedy algorithms and one linear programming relaxation algorithm. The experimental results indicate that (1) the solutions found by these algorithms are quite close to the optimal solution; (2) the genotyping cost saved by using tag SNPs can be as high as 80%; and (3) genotyping additional tag SNPs for tolerating missing data is still cost-effective.

Conclusion
Genotyping robust tag SNPs is more practical than just genotyping the minimum tag SNPs if we can not avoid the occurrence of missing data. Our theoretical analysis and experimental results show that the performance of our algorithms is not only efficient but the solution found is also close to the optimal solution.
The neuroblast and angioblast chemotaxic factor SDF-1 (CXCL12) expression is briefly up regulated by reactive astrocytes in brain following neonatal hypoxic-ischemic injury
Authors: Miller Jason T , Bartley John H , Wimborne Hereward JC , Walker Aisha L , Hess David C , Hill William D , Carroll James E 
Published: November 2005

Abstract

Background
Stromal cell-derived factor 1 (SDF-1 or CXCL12) is chemotaxic for CXCR4 expressing bone marrow-derived cells. It functions in brain embryonic development and in response to ischemic injury in helping guide neuroblast migration and vasculogenesis. In experimental adult stroke models SDF-1 is expressed perivascularly in the injured region up to 30 days after the injury, suggesting it could be a therapeutic target for tissue repair strategies. We hypothesized that SDF-1 would be expressed in similar temporal and spatial patterns following hypoxic-ischemic (HI) injury in neonatal brain.

Results
Twenty-five 7-day-old C57BL/J mice underwent HI injury. SDF-1 expression was up regulated up to 7 days after the injury but not at the later time points. The chief sites of SDF-1 up regulation were astrocytes, their foot processes along blood vessels and endothelial cells.

Conclusion
The localization of SDF-1 along blood vessels in the HI injury zone suggests that these perivascular areas are where chemotaxic signaling for cellular recruitment originates and that reactive astrocytes are major mediators of this process. The associated endothelium is likely to be the site for vascular attachment and diapedesis of CXCR4 receptor expressing cells to enter the injured tissue. Here we show that, relative to adults, neonates have a significantly smaller window of opportunity for SDF-1 based vascular chemotaxic recruitment of bone marrow-derived cells. Therefore, without modification, following neonatal HI injury there is only a narrow period of time for endogenous SDF-1 mediated chemotaxis and recruitment of reparative cells, including exogenously administered stem/progenitor cells.
Parametric versus non-parametric statistics in the analysis of randomized trials with non-normally distributed data
Authors: Vickers Andrew J 
Published: November 2005

AbstractBackgroundIt has generally been argued that parametric statistics should not be applied to data with non-normal distributions. Empirical research has demonstrated that Mann-Whitney generally has greater power than thet-test unless data are sampled from the normal. In the case of randomized trials, we are typically interested in how an endpoint, such as blood pressure or pain, changes following treatment. Such trials should be analyzed using ANCOVA, rather thant-test. The objectives of this study were: a) to compare the relative power of Mann-Whitney and ANCOVA; b) to determine whether ANCOVA provides an unbiased estimate for the difference between groups; c) to investigate the distribution of change scores between repeat assessments of a non-normally distributed variable.MethodsPolynomials were developed to simulate five archetypal non-normal distributions for baseline and post-treatment scores in a randomized trial. Simulation studies compared the power of Mann-Whitney and ANCOVA for analyzing each distribution, varying sample size, correlation and type of treatment effect (ratio or shift).ResultsChange between skewed baseline and post-treatment data tended towards a normal distribution. ANCOVA was generally superior to Mann-Whitney in most situations, especially where log-transformed data were entered into the model. The estimate of the treatment effect from ANCOVA was not importantly biased.ConclusionANCOVA is the preferred method of analyzing randomized trials with baseline and post-treatment measures. In certain extreme cases, ANCOVA is less powerful than Mann-Whitney. Notably, in these cases, the estimate of treatment effect provided by ANCOVA is of questionable interpretability.
High carriage rate of high-level penicillin-resistant Streptococcus pneumoniaein a Taiwan kindergarten associated with a case of pneumococcal meningitis
Authors: Lauderdale Tsai-Ling , Lee Wei Yang , Cheng Ming Fang , Huang I Fei , Lin Yu Chen , Hseih Kai Sheng , Huang I-Wen , Chiou Christine C 
Published: November 2005

Abstract

Background
The Taiwan19F-14 Streptococcus pneumoniae clone and its variants are being found with increasing frequency in the Asia-Pacific region. A 5-year old child with S. pneumoniae meningitis caused by a high-level penicillin resistant strain (MIC = 4 μg/ml) was admitted to a hospital in southern Taiwan. We carried out a study to determine the potential source of this strain.

Methods
Nasopharyngeal cultures were obtained from all children attending the same kindergarten as the index case. To determine their relatedness all isolates were compared by serotype, antimicrobial susceptibility profile and pulsed field gel electrophoresis (PFGE).

Results
A high proportion of the children including the index case (32/78, 41.0%) carried S. pneumoniae in their nasopharynx (NP). The most common serotype was 19F (13/32, 40.6%). The PFGE types of the 19F serotype isolates obtained from the patient's blood, CSF and NP were identical and were related to 11 other serotype 19F NP isolates including 10 that were indistinguishable from the Taiwan19F-14 clone. All 14 isolates had similar high-level penicillin and multi-drug resistance. The serotypes of the other 19 NP isolates included 6A (2), 6B (10), 23F (5), 9V (1) and 3 (1). The overall rate of penicillin resistance in these S. pneumoniae from these children was 87.5% (28/32), with an MIC50 of 2 and MIC90 of 4 ug/ml. In addition, multi-drug resistant-isolates (isolates resistant to 3 different classes of antimicrobials) accounted for 87.5% (28/32) of all isolates.

Conclusion
The high carriage rate of high-level penicillin- and multi-drug- resistant S. pneumoniae in a kindergarten associated with a case of pneumococcal meningitis emphasizes the need for restraint in antibiotic use and consideration of childhood immunization with conjugate pneumococcal vaccine to prevent the further spread of resistant S. pneumoniae in Taiwan.
A functional profile of gene expression in ARPE-19 cells
Authors: Sharma Rajesh K , Orr William E , Schmitt Allyson D , Johnson Dianna A 
Published: November 2005

Abstract

Background
Retinal pigment epithelium cells play an important role in the pathogenesis of age related macular degeneration. Their morphological, molecular and functional phenotype changes in response to various stresses. Functional profiling of genes can provide useful information about the physiological state of cells and how this state changes in response to disease or treatment. In this study, we have constructed a functional profile of the genes expressed by the ARPE-19 cell line of retinal pigment epithelium.

Methods
Using Affymetrix MAS 5.0 microarray analysis, genes expressed by ARPE-19 cells were identified. Using GeneChip® annotations, these genes were classified according to their known functions to generate a functional gene expression profile.

Results
We have determined that of approximately 19,044 unique gene sequences represented on the HG-U133A GeneChip® , 6,438 were expressed in ARPE-19 cells irrespective of the substrate on which they were grown (plastic, fibronectin, collagen, or Matrigel). Rather than focus our subsequent analysis on the identity or level of expression of each individual gene in this large data set, we examined the number of genes expressed within 130 functional categories. These categories were selected from a library of HG-U133A GeneChip® annotations linked to the Affymetrix MAS 5.0 data sets. Using this functional classification scheme, we were able to categorize about 70% of the expressed genes and condense the original data set of over 6,000 data points into a format with 130 data points. The resulting ARPE-19 Functional Gene Expression Profile is displayed as a percentage of ARPE-19-expressed genes.

Conclusion
The Profile can readily be compared with equivalent microarray data from other appropriate samples in order to highlight cell-specific attributes or treatment-induced changes in gene expression. The usefulness of these analyses is based on the assumption that the numbers of genes expressed within a functional category provide an indicator of the overall level of activity within that particular functional pathway.