bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Intrinsic Photothermal Supramolecular Hydrogel with Robust Mechanical Strength and NIR‐Responsive Shape Memory
Authors: Wang Ruyue , Chen Xingxing , Cheng Yilong , Ding Zicheng , Ming Xiaoqing , Zhang Yanfeng 
Published: March 2024

AbstractNear‐infrared (NIR)‐triggered shape memory hydrogels with promising mechanical strength hold immense potential in the field of biomedical applications and soft actuators. However, the optical and mechanical properties of currently reported hydrogels usually suffer from limited solubility and dispersion of commonly used photothermal additives in hydrogels, thus restricting their practical implementations. Here,, a set of NIR‐responsive shape memory hydrogels synthesized by polyaddition of diisocyanate‐terminated poly(ethylene glycol), imidazolidinyl urea (IU), and p‐benzoquinone dioxime (BQDO) is reported. The introduction of IU, a hydrogen bond reinforcing factor, significantly enhances the mechanical properties of the hydrogels, allowing for their tunable ranges of the ultimate tensile strength (0.4–2.5 MPa), elongation at break (210–450%), and Young's modulus (190–850 kPa). The unique hydrogels exhibit an intrinsic photothermal effect because of the covalently incorporated photothermal moiety (BQDO), and the photothermal supramolecular hydrogel shows controllable shape memory capabilities characterized by rapid recovery speed and high recovery ratio (>90%). This design provides new possibilities for applying shape memory hydrogels in the field of soft actuators.
A novel in‐frame deletion in KIF5C gene causes infantile onset epilepsy and psychomotor retardation
Authors: Banerjee Santasree , Zhao Qiang , Wang Bo , Qin Jiale , Yuan Xin , Lou Ziwei , Zheng Weizeng , Li Huanguo , Wang Xiaojun , Cheng Xiawei , Zhu Yu , Lin Fan , Yang Fan , Xu Junyu , Munshi Anjana , Das Parimal , Zhou Yuanfeng , Mandal Kausik , Wang Yi , Ayub Muhammad , Hirokawa Nobutaka , Xi Yongmei , Chen Guangfu , Li Chen 
Published: March 2024

AbstractMotor proteins, encoded by Kinesin superfamily (KIF) genes, are critical for brain development and plasticity. Increasing studies reported KIF’s roles in neurodevelopmental disorders. Here, a 6 years and 3 months‐old Chinese boy with markedly symptomatic epilepsy, intellectual disability, brain atrophy, and psychomotor retardation was investigated. His parents and younger sister were phenotypically normal and had no disease‐related family history. Whole exome sequencing identified a novel heterozygous in‐frame deletion (c.265_267delTCA) in exon 3 of the KIF5C in the proband, resulting in the removal of evolutionarily highly conserved p.Ser90, located in its ATP‐binding domain. Sanger sequencing excluded the proband's parents and family members from harboring this variant. The activity of ATP hydrolysis in vitro was significantly reduced as predicted. Immunofluorescence studies showed wild‐type KIF5C was widely distributed throughout the cytoplasm, while mutant KIF5C was colocalized with microtubules. The live‐cell imaging of the cargo‐trafficking assay revealed that mutant KIF5C lost the peroxisome‐transporting ability. Drosophila models also confirmed p.Ser90del's essential role in nervous system development. This study emphasized the importance of the KIF5C gene in intracellular cargo‐transport as well as germline variants that lead to neurodevelopmental disorders and might enable clinicians for timely and accurate diagnosis and disease management in the future.
Profiling of Metabolites in a Fermented Soy Dietary Supplement Reinforces its Role in the Management of Intestinal Inflammation
Authors: Ethier Richard , Krishnamurthy Arun , Jeffrey Michael , Tompkins Thomas A. 
Published: March 2024

ScopeGastro‐AD (GAD) is a soy flour derived product that undergoes an industrial fermentation with Lactobacillus delbrueckii R0187 and has demonstrated clinical effects in gastroesophageal reflux and peptic ulcer symptom resolution. The aim of this study is to describe and link GAD's metabolomic profile to plausible mechanisms that manifest and explain the documented clinical outcomes.Methods and results1H NMR spectroscopy with multivariate statistical analysis is used to characterize the prefermented soy flour and GAD products. The acquired spectra are screened using various resources and the molecular assignments are confirmed using total correlation spectroscopy (TOCSY). Peaks corresponding to different metabolites are integrated and compared between the two products for relative changes. HPLC and GC are used to quantify some specific molecules. NMR analyses demonstrate significant changes in the composition of various assigned bioactive moieties. HPLC and GC analysis demonstrate deglycation of isoflavones after fermentation, resulting in estrogenically active secondary metabolites that have been previously shown to help to reduce inflammation.ConclusionThe identification of bioactive molecules, such as genistein and SCFAs, capable of modulating anti‐inflammatory signaling cascades in the stomach's gastric and neuroendocrine tissues can explain the reported biological effects in GAD and is supported by in vivo data.
A novel minority sample fault diagnosis method based on multisource data enhancement
Authors: Guo Yiming , Song Shida , Huang Jing 
Published: March 2024

AbstractEffective fault diagnosis has a crucial impact on the safety and cost of complex manufacturing systems. However, the complex structure of the collected multisource data and scarcity of fault samples make it difficult to accurately identify multiple fault conditions. To address this challenge, this paper proposes a novel deep‐learning model for multisource data augmentation and small sample fault diagnosis. The raw multisource data are first converted into two‐dimensional images using the Gramian Angular Field, and a generator is built to transform random noise into images through transposed convolution operations. Then, two discriminators are constructed to evaluate the authenticity of input images and the fault diagnosis ability. The Vision Transformer network is built to diagnose faults and obtain the classification error for the discriminator. Furthermore, a global optimization strategy is designed to upgrade parameters in the model. The discriminators and generator compete with each other until Nash equilibrium is achieved. A real‐world multistep forging machine is adopted to compare and validate the performance of different methods. The experimental results indicate that the proposed method has multisource data augmentation and minority sample fault diagnosis capabilities. Compared with other state‐of‐the‐art models, the proposed approach has better fault diagnosis accuracy in various scenarios.
Classic grounded theory: identifying the main concern
Authors: Connor Justine , Flenady Tracy , Massey Deb , Dwyer Trudy 
Published: March 2024

AbstractGrounded theory comprises a family of research approaches designed to support the generation of a theory explaining a phenomenon experienced by a group of participants. One style of grounded theory, Classic grounded theory, is used less often than other types of grounded theory. The less frequent use of Classic grounded theory may be attributed to the limited availability of clearly articulated processes for conducting this method. Particularly important within Classic grounded theory, and not used in other forms of grounded theory, is identifying the participants' main concern. Identifying the participants' main concern is a signature feature of Classic grounded theory and is a prerequisite for ascertaining the core category and subsequent discovery of theory. In this article we provide a detailed explanation of how to identify the participants' main concern, and in so doing, we offer an exemplar to illustrate the process involved.
A review of the effects of legal access to same‐sex marriage
Authors: Badgett M. V. Lee , Carpenter Christopher S. , Lee Maxine J. , Sansone Dario 
Published: March 2024

AbstractOn June 26, 2015, the United States Supreme Court extended nationwide legal access to same‐sex marriage in Obergefell v. Hodges, following a series of court cases and legislative activities at the state and district levels. Similar policies have diffused throughout other countries, especially in western Europe and the Americas. Researchers have used the staggered rollout of legal same‐sex marriage and related policies in the U.S. and elsewhere, along with improved data on lesbian, gay, and bisexual people, to study the effects of marriage equality. In this paper, we review this evidence, focusing on outcomes such as societal attitudes, marriage take‐up, family formation, employment, time use, health insurance coverage, and health. We discuss conceptual frameworks for understanding the likely effects of same‐sex marriage; methodological considerations for studying treatment effects; the policy context surrounding legal same‐sex marriage, including the 2023 Respect for Marriage Act; and important areas for future research.
Unraveling the underlying mechanisms of reduced amyloidogenic properties in human calcitonin via double mutations
Authors: Chang Yu‐Pei , Pan Pei‐Chun , Tu Ling‐Hsien 
Published: March 2024

AbstractThe therapeutic efficacy of peptide‐based drugs is commonly hampered by the intrinsic propensity to aggregation. A notable example is human calcitonin (hCT), a peptide hormone comprising 32 amino acids, which is synthesized and secreted by thyroid gland parafollicular cells (C cells). This hormone plays a vital role in regulating blood calcium levels and upholding bone integrity. Despite its physiological importance, utilizing hCT as a drug is hampered by its inclination to form amyloid. To address this limitation, an alternative is provided by salmon calcitonin (sCT), which possesses a lower aggregation propensity. Although sharing the same disulfide bond at the N terminus as hCT, sCT differs from hCT at a total of 16 amino acid positions. However, due to the dissimilarity in sequences, using sCT as a clinical replacement occasionally results in adverse side effects in patients. Earlier investigations have highlighted the significant roles of Tyr‐12 and Asn‐17 in inducing the formation of amyloid fibrils. By introducing double mutations at these sites, the ability to hinder aggregation can be significantly augmented. This study delves into the oligomerization and helical structure formation of the hCT double mutant (Y12LN17H hCT, noted as DM hCT), as well as two single mutants (Y12L and N17H), aiming to elucidate the mechanism behind hCT fibrillization. In addition, computational prediction tools were employed again to identify potential substitutes. Although the results yielded were not entirely satisfactory, a comparison between the newly examined and previously found hCT double mutants provides insights into the reduced aggregation propensity of the latter. This research endeavor holds the promise of informing the design of more effective therapeutic peptide drugs in the future.
Phytotherapeutic approach for conquering menopausal syndrome and osteoporosis
Authors: Mohapatra Sradhanjali , Kumar P Ayash , Aggarwal Akshay , Iqubal Ashif , Mirza Mohd Aamir , Iqbal Zeenat 
Published: March 2024

AbstractWomen face a significant change in their reproductive health as menopause sets in. It is marred with numerous physiological changes that negatively impact their quality of life. This universal, transition phase is associated with menopausal and postmenopausal syndrome, which may spread over 2–10 years. This creates a depletion of female hormones causing physical, mental, sexual and social problems and may, later on, manifest as postmenopausal osteoporosis leading to weak bones, causing fractures and ultimately morbidity and mortality. Menopausal hormone therapy generally encompasses the correction of hormone balance through various pharmacological agents, but the associated side effects often lead to cessation of therapy with poor clinical outcomes. However, it has been noticed that phytotherapeutics is trusted by women for the amelioration of symptoms related to menopause and for improving bone health. This could primarily be due to their reduced side effects and lesser costs. This review attempts to bring forth the suitability of phytotherapeutics/herbals for the management of menopausal, postmenopausal syndrome, and menopausal osteoporosis through several published research. It tries to enlist the available botanicals with their key constituents and mechanism of action for mitigating symptoms associated with menopause as well as osteoporosis. It also includes a list of a few herbal commercial products available for these complications. The article also intends to collate the findings of various clinical trials and patents available in this field and provide a window for newer research avenues in this highly important yet ignored health segment.
Electrochemical Failure Mechanism of δ‐MnO2 in Zinc Ion Batteries Induced by Irreversible Layered to Spinel Phase Transition
Authors: Zhao Chunyu , Wu Mengqi , Lu Wencheng , Cheng Yingjie , Zhang Xiaoya , Saadoune Ismael , Lian Ruqian , Wang Yizhan , Wei Yingjin 
Published: March 2024

AbstractPhase transitions of Mn‐based cathode materials associated with the charge and discharge process play a crucial role on the rate capability and cycle life of zinc ion batteries. Herein, a microscopic electrochemical failure mechanism of Zn‐MnO2 batteries during the phase transitions from δ‐MnO2 to λ‐ZnMn2O4 is presented via systematic first‐principle investigation. The initial insertion of Zn2+ intensifies the rearrangement of Mn. This is completed by the electrostatic repulsion and co‐migration between guest and host ions, leading to the formation of λ‐ZnMn2O4. The Mn relocation barrier for the λ‐ZnMn2O4 formation path with 1.09 eV is significantly lower than the δ‐MnO2 re‐formation path with 2.14 eV, indicating the irreversibility of the layered‐to‐spinel transition. Together with the phase transition, the rearrangement of Mn elevates the Zn2+ migration barrier from 0.31 to 2.28 eV, resulting in poor rate performance. With the increase of charge–discharge cycles, irreversible and inactive λ‐ZnMn2O4 products accumulate on the electrode, causing continuous capacity decay of the Zn‐MnO2 battery.
Exploring the effects of TiO2${\rm TiO}_2$–Ag/water hybrid nanofluid on MHD flow over a permeable exponentially stretching–shrinking sheet with radiative heat transfer and slip conditions
Authors: Patel Vijay K. , Pandya Jigisha U. , Patel Manoj R. 
Published: March 2024

AbstractThe objective of this article is to study the importance of velocity and thermal slip in the exponentially stretching or shrinking sheet with the megnetohydrodynamic (MHD) hybrid nanofluid flow along with magnetic field, radiative, heat generation effects. This study has practical importance in enhancing heat transfer efficiency, improving energy conversion and optimizing thermal management systems. The findings can also contribute to the development of sustainable energy systems and aid in assessing the stability and safety of nanofluid applications. The governing partial differential equations are transformed into nonlinear ordinary differential equations using similarity transformation. The ODEs are solved using bvp4c solver in MATLAB. The dual solutions are achieved for specific range of the stretching or shrinking parameter and mass suction parameter. The first solution is physically significant after considering stability analysis. The hybrid nanofluid has numerous real‐life and industrial applications, such as microelectronics, manufacturing, naval structures, nuclear system cooling, biomedical, and drug reduction. The skin‐friction increases but Nusselt number decreases over the stretching sheet whereas the opposite effect shows over shrinking sheet for the both solution with the increasing velocity slip parameter. On the other hand, The Nusselt number decreases over the shrinking or stretching sheet for both solutions with the increasing in the thermal slip parameter. The skin friction increases over shrinking sheet but decreases over stretching sheet for the first solution with increasing silver volume fraction parameter and porosity parameter (). Enhancing magnetic field parameter leads to the skin friction increases over the shrinking sheet but decreases over stretching sheet but Nusselt number shows opposite trend. The Nusselt number decreases over shrinking sheet but increases over stretching sheet for the first solution with increasing porosity parameter (). The Nusselt number decreases over shrinking or stretching sheet as the increases heat generation () and variable thermal conductivity parameter () but Nusselt number shows opposite trend as the increases radiative parameter ().
Simple Lyapunov spectrum for linear homogeneous differential equations with $$L^p$$ parameters
Authors: Amaro Dinis , Bessa Mário , Vilarinho Helder 
Published: March 2024

AbstractIn the present paper we prove that densely, with respect to an $$L^p$$

L
p

-like topology, the Lyapunov exponents associated to linear continuous-time cocycles $$\Phi :\mathbb {R}\times M\rightarrow {{\,\textrm{GL}\,}}(2,\mathbb {R})$$

Φ
:
R
×
M
→

GL

(
2
,
R
)

induced by second order linear homogeneous differential equations $$\ddot{x}+\alpha (\varphi ^t(\omega ))\dot{x}+\beta (\varphi ^t(\omega ))x=0$$

x
¨

+
α

(

φ
t

(
ω
)

)

x
˙

+
β

(

φ
t

(
ω
)

)

x
=
0

are almost everywhere distinct. The coefficients $$\alpha ,\beta $$

α
,
β

evolve along the $$\varphi ^t$$

φ
t

-orbit for $$\omega \in M$$

ω
∈
M

and $$\varphi ^t: M\rightarrow M$$

φ
t

:
M
→
M

is an ergodic flow defined on a probability space. We also obtain the corresponding version for the frictionless equation $$\ddot{x}+\beta (\varphi ^t(\omega ))x=0$$

x
¨

+
β

(

φ
t

(
ω
)

)

x
=
0

and for a Schrödinger equation $$\ddot{x}+(E-Q(\varphi ^t(\omega )))x=0$$

x
¨

+

(
E
-
Q

(

φ
t

(
ω
)

)

)

x
=
0

, inducing a cocycle $$\Phi :\mathbb {R}\times M\rightarrow {{\,\textrm{SL}\,}}(2,\mathbb {R})$$

Φ
:
R
×
M
→

SL

(
2
,
R
)

.
The zoogeographic regionalization for cephalopoda linked to the canary current upwelling system
Authors: Luna Amanda , Ramos Ana , Rocha Francisco 
Published: March 2024

AbstractQuantitative data on cephalopods collected in ten multidisciplinary surveys (20–2000 m) between 2004 and 2012, together with original oceanographic and satellite data, were analyzed using multivariate techniques. Statistical analyses were based on presence–absence matrices by species and hydrological variable indices. The results show that cephalopods are distributed in two main zoogeographical groups separated by latitude: “Temperate water” and “Tropical water” clusters. They extended by temperate and tropical regions, separated by a geographical boundary, Cape Blanc, particularly strong in the case of coastal species between these groups. For the total fauna, we have identified a third particular cephalopods’ cluster, the “Upwelling” cluster (22°–17°N), characterized by a higher diversity and dominance of oceanic cephalopods. This is proposed as a new zoogeographical region that would coincide with the area of greatest productivity, intensity and permanence throughout the year of the canary current upwelling, confined between the north of Cape Blanc and the south of Mauritania. The results confirm the strong relationship between the three zoogeographical regions (temperate, tropical, and upwelling) and certain water bodies that characterize the regional hydrology. This paper deepens into the zoogeography of the cephalopods from Northwest Africa (Central-Eastern Atlantic), providing a new, more detailed insight into the region and its boundaries in relation to the oceanography.
Endothelial dysfunction and risk factors for atherosclerosis in psoriatic arthritis: overview and comparison with rheumatoid arthritis
Authors: Kaleta Konrad , Krupa Julia , Suchy Wiktoria , Sopel Anna , Korkosz Mariusz , Nowakowski Jarosław 
Published: March 2024

AbstractEndothelial dysfunction (ED) is defined as an impairment in the vasodilatory, anti-thrombotic, and anti-inflammatory properties of the cells that make up the lining of blood vessels. ED is considered a key step in the development of atherosclerotic cardiovascular disease. The association between ED and systemic inflammatory diseases is well established. However, the prevalence and clinical significance of ED in psoriatic arthritis (PsA) have been investigated to a lesser extent. This review aims to explore the link between ED and PsA, including ED in macro- and microcirculation, as well as risk factors for its occurrence in PsA and its relationship with atherosclerosis in PsA. Furthermore, the ED in PsA was compared with that of rheumatoid arthritis (RA). Regarding ED in the microcirculation, the coronary flow reserve was found to be significantly reduced in individuals with PsA. The relationship between PsA and macrovascular ED is more pronounced, along with more advanced atherosclerosis detected in patients with PsA. These results are consistent with those obtained in RA studies. On the other hand, arterial stiffness and signs of vascular remodeling were found more frequently in RA than in PsA, with the potential role of efficient anti-TNF treatment in patients with PsA and psoriasis explaining this finding. The impact of ED on cardiovascular diseases and the burden of this risk caused independently by PsA have not yet been precisely established, however, this group of patients requires special attention with regard to cardiovascular events.
Dysphagia Prevalence in Progressive Supranuclear Palsy: A Systematic Review and Meta-Analysis
Authors: Glinzer Julia , Flynn Éadaoin , Tampoukari Eleni , Harpur Isolde , Walshe Margaret 
Published: March 2024

Abstract
The objective of this systematic review was to determine the prevalence of dysphagia and aspiration in people with progressive supranuclear palsy (PSP). A search of six electronic databases was performed from inception to April 2022. No context restrictions were set. All primary research comprising figures to derive a prevalence rate were included. Two independent reviewers screened search results. Data were extracted by one reviewer. Conflicts were resolved by discussion with a third reviewer. The quality of included studies was assessed using the JBI Checklist for Prevalence Studies. From 877 studies, 12 were eligible for inclusion. Dysphagia had to be confirmed using instrumental assessments, clinical swallowing evaluation, screening, and patient-reported outcome measures (PROM). A random-effects meta-analysis calculated a pooled dysphagia prevalence in 78–89% (95% CI [60.6, 89.1], [78.9, 95.0]). depending on the chosen assessment method, and a pooled aspiration prevalence of 23.5% (95% CI [14.5, 33.7]). The included studies were of moderate quality, with high risk of selection and coverage bias and low to moderate risk of measurement bias. Dysphagia is highly prevalent in a sample of participants with mostly moderately severe PSP. Aspiration occurs in a quarter of this sample and is likely to increase as the disease progresses. Given the low general prevalence of PSP, studies remain at high risk for selection bias. Prospective research should focus on the development of dysphagia in the course of PSP and its subcategories using instrumental assessment and consider all phases of swallowing.

Registration
The protocol of this systematic review was registered on the International Prospective Register of Systematic Reviews (PROSPERO) in April 2021 (registration number: CRD42021245204).