bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamic molecular network analysis of iPSC-Purkinje cells differentiation delineates roles of ISG15 in SCA1 at the earliest stage
Authors: Homma Hidenori , Yoshioka Yuki , Fujita Kyota , Shirai Shinichi , Hama Yuka , Komano Hajime , Saito Yuko , Yabe Ichiro , Okano Hideyuki , Sasaki Hidenao , Tanaka Hikari , Okazawa Hitoshi 
Published: April 2024

AbstractBetter understanding of the earliest molecular pathologies of all neurodegenerative diseases is expected to improve human therapeutics. We investigated the earliest molecular pathology of spinocerebellar ataxia type 1 (SCA1), a rare familial neurodegenerative disease that primarily induces death and dysfunction of cerebellum Purkinje cells. Extensive prior studies have identified involvement of transcription or RNA-splicing factors in the molecular pathology of SCA1. However, the regulatory network of SCA1 pathology, especially central regulators of the earliest developmental stages and inflammatory events, remains incompletely understood. Here, we elucidated the earliest developmental pathology of SCA1 using originally developed dynamic molecular network analyses of sequentially acquired RNA-seq data during differentiation of SCA1 patient-derived induced pluripotent stem cells (iPSCs) to Purkinje cells. Dynamic molecular network analysis implicated histone genes and cytokine-relevant immune response genes at the earliest stages of development, and revealed relevance of ISG15 to the following degradation and accumulation of mutant ataxin-1 in Purkinje cells of SCA1 model mice and human patients.
Pancreatic cancer-associated fibroblasts modulate macrophage differentiation via sialic acid-Siglec interactions
Authors: Boelaars Kelly , Rodriguez Ernesto , Huinen Zowi R. , Liu Chang , Wang Di , Springer Babet O. , Olesek Katarzyna , Goossens-Kruijssen Laura , van Ee Thomas , Lindijer Dimitri , Tak Willemijn , de Haas Aram , Wehry Laetitia , Nugteren-Boogaard Joline P. , Mikula Aleksandra , de Winde Charlotte M. , Mebius Reina E. , Tuveson David A. , Giovannetti Elisa , Bijlsma Maarten F. , Wuhrer Manfred , van Vliet Sandra J. , van Kooyk Yvette 
Published: April 2024

AbstractDespite recent advances in cancer immunotherapy, pancreatic ductal adenocarcinoma (PDAC) remains unresponsive due to an immunosuppressive tumor microenvironment, which is characterized by the abundance of cancer-associated fibroblasts (CAFs). Once identified, CAF-mediated immune inhibitory mechanisms could be exploited for cancer immunotherapy. Siglec receptors are increasingly recognized as immune checkpoints, and their ligands, sialic acids, are known to be overexpressed by cancer cells. Here, we unveil a previously unrecognized role of sialic acid-containing glycans on PDAC CAFs as crucial modulators of myeloid cells. Using multiplex immunohistochemistry and transcriptomics, we show that PDAC stroma is enriched in sialic acid-containing glycans compared to tumor cells and normal fibroblasts, and characterized by ST3GAL4 expression. We demonstrate that sialic acids on CAF cell lines serve as ligands for Siglec-7, -9, -10 and -15, distinct from the ligands on tumor cells, and that these receptors are found on myeloid cells in the stroma of PDAC biopsies. Furthermore, we show that CAFs drive the differentiation of monocytes to immunosuppressive tumor-associated macrophages in vitro, and that CAF sialylation plays a dominant role in this process compared to tumor cell sialylation. Collectively, our findings unravel sialic acids as a mechanism of CAF-mediated immunomodulation, which may provide targets for immunotherapy in PDAC.
Probiotics reshape the coral microbiome in situ without detectable off-target effects in the surrounding environment
Authors: Delgadillo-Ordoñez Nathalia , Garcias-Bonet Neus , Raimundo Inês , García Francisca C. , Villela Helena , Osman Eslam O. , Santoro Erika P. , Curdia Joao , Rosado Joao G. D. , Cardoso Pedro , Alsaggaf Ahmed , Barno Adam , Antony Chakkiath Paul , Bocanegra Carolina , Berumen Michael L. , Voolstra Christian R. , Benzoni Francesca , Carvalho Susana , Peixoto Raquel S. 
Published: April 2024

AbstractBeneficial microorganisms for corals (BMCs), or probiotics, can enhance coral resilience against stressors in laboratory trials. However, the ability of probiotics to restructure the coral microbiome in situ is yet to be determined. As a first step to elucidate this, we inoculated putative probiotic bacteria (pBMCs) on healthy colonies of Pocillopora verrucosa in situ in the Red Sea, three times per week, during 3 months. pBMCs significantly influenced the coral microbiome, while bacteria of the surrounding seawater and sediment remained unchanged. The inoculated genera Halomonas, Pseudoalteromonas, and Bacillus were significantly enriched in probiotic-treated corals. Furthermore, the probiotic treatment also correlated with an increase in other beneficial groups (e.g., Ruegeria and Limosilactobacillus), and a decrease in potential coral pathogens, such as Vibrio. As all corals (treated and non-treated) remained healthy throughout the experiment, we could not track health improvements or protection against stress. Our data indicate that healthy, and therefore stable, coral microbiomes can be restructured in situ, although repeated and continuous inoculations may be required in these cases. Further, our study provides supporting evidence that, at the studied scale, pBMCs have no detectable off-target effects on the surrounding microbiomes of seawater and sediment near inoculated corals.
Triple oxygen isotope compositions reveal transitions in the moisture source of West China Autumn Precipitation
Authors: Sha Lijuan , Tian Lijun , Sha Lifen , Li Yunxia , Wang Xuejie , Hu Peng , Liang Qisheng , Zong Baoyun , Duan Pengzhen , Cheng Hai 
Published: April 2024

AbstractThe isotopic composition has long been used to investigate the factors influencing precipitation, whereas the variations of event-based precipitation isotopes caused by moisture transition and synoptic meteorological conditions remain limited. Here we present triple oxygen and hydrogen isotopes in event-based precipitation during West China Autumn Precipitation to evaluate the influence of various moisture sources in the hydrological process. Isotopes δ18O, δ17O, and δD peak with convective precipitation at the onset stage, then drop to their lowest amid stratiform precipitation during the middle stage, and rise again towards the end. In contrast, Δ′17O levels remain elevated throughout the mid-stage of West China Autumn Precipitation compared to the onset and end stages. These isotopic variations, coupled with moisture analysis, reveal a distinct moisture source transition from the West Pacific Ocean to the westerly domain during West China Autumn Precipitation accompanied by the retreat of the Asian summer monsoon from Northwest China.
Pope Francis the Roman Catholic Church and citizen attitudes towards climate change in Latin America
Authors: Ecker Alejandro , Nüssel Friederike , Tosun Jale 
Published: April 2024

AbstractStudies on the relationship between religious attitudes and attitudes towards climate change and other environmental issues have tended to focus on the United States. While there is good reason to expect such a relationship to exist, our understanding of it is limited first and foremost by the limited number of country-comparative studies. This study aims to reduce this gap by investigating how trust in the Church and evaluations of Pope Francis affect the views of Latin Americans on anthropogenic climate change. Our study is based on data from the 2017 Latinobarómetro with 13,472 respondents based in 18 Latin American countries. Our findings reveal that Roman Catholics are less likely to believe in manmade climate change as compared to evangelical Christians and respondents belonging to no or any other denomination. We obtain the same negative relationship between trust in the (Catholic) Church and belief in anthropogenic climate change. However, favourable assessments of Pope Francis have a positive effect, and this assessment also has a positive moderating effect on the impact of trust in the Church on the outcome variable. These findings have important implications for climate policies, as they suggest that the public demand for climate action might increase if the Roman Catholic Church in their regional dioceses, rather than mostly the Pope, were to take and communicate a more coherent, affirmative position on climate change.
Intimately mixed copper, cobalt, and iron fluorides resulting from the insertion of fluorine into a LDH template
Authors: Rouag Abderraouf , Porhiel Régis , Lemoine Kevin , Leroux Fabrice , Grenèche Jean-Marc , Delbègue Diane , Iojoiu Cristina , Guérin Katia 
Published: April 2024

Cu3Fe1.5Al0.5F12(H2O)12 and CoFeF5-type phases from gaseous fluorination of LDH.
Quantifying potential fluid transfused through pressure monitoring and circuit flushes in pediatric ECMO patients
Authors: Robertson Steven , White Katherine 
Published: April 2024

Pressure monitoring on pediatric Extracorporeal Membrane Oxygenation (ECMO) circuits is used to aid in the evaluation of patient hemodynamics and circuit health. Extracorporeal Life Support Organization (ELSO) recommends monitoring pressures on the venous line, pre-, and post-oxygenator. In order to keep pressure ports patent, crystalloid can be used as a flush. The fluid transfused to the patient through these lines can be challenging to quantify accurately due to variance in clinician practice. Currently, there is no published data or practice suggestions on this topic. In Vitro experiments using Edwards True Wave transducers and pressure bags were constructed, allowing for common negative and positive pressures to be simulated. Passive volume infused through the transducer as well as intermittent active flushing by pulling the snap tab were measured and the volumes were recorded. When the pressure transducer and associated tubing are kept patent by using a pressurized IV bag, per the instructions for use, the daily volume transfused was found to be 319.6 mL or close to a typical neonate’s total blood volume. Rather than using passive or active flushing, the use of automated syringe pumps can reduce the transfused volume to 24 mL per day. Further study is recommended to develop and publish best practices.
An Improved Iodine-Catalyzed Aromatization Reaction and Its Application in the Synthesis of a Key Intermediate of Cannabidiol
Authors: Zhu Fuqiang , Shen Jingshan , Abduahadi Safomuddin , Mintah Bonku Emmanuel , Qin Hongjian , Odilov Abdullajon , Aisa Haji Akber 
Published: April 2024

AbstractIn this study, the development of an improved process for the synthesis of a key cannabidiol intermediate, methyl olivetolate, is described. The process involves an improvement of the iodine-catalyzed aromatization of cyclohexanone using potassium persulfate as an oxidant. This approach enabled for the efficient synthesis of methyl olivetolate with a 90% yield and 99.84% HPLC purity on a 5 kg scale. Additionally, a total of 19 cyclohexanone substrates afforded higher yields (71–92%) of m-diphenol compounds compared to the established methods.
Iron-Catalyzed Oxidative C(sp3)–C(sp3) Radical Coupling Reaction between Thiohydantoins and O-Acetyloximes for the Synthesis of 1,3-Dibenzyl-3,4-dihydropyrrolo[2,3-d]imidazole-2(1H)-thione Derivatives
Authors: Chikhalia Kishor H. , Patel Parth P. 
Published: April 2024

AbstractA unified heteroannelation method to achieve the synthesis of 1,3-dibenzyl-3,4-dihydropyrrolo[2,3-d]imidazole-2(1H)-thione derivatives with an iron catalyst is proposed. The annelation reaction follows a C(sp3)–C(sp3) radical coupling between a thiohydantoin and an O-acetyloxime. The synthetic approach enables access to several alkynylated thiohydantoins and O-acetyloximes with controlled selectivity toward C(sp3)–C(sp3) coupling rather than C(sp3)–C(sp3)–O coupling in moderate to high yields. An optimization study has been carried out by changing the catalyst loading, oxidants, solvents, and temperature. Synthesized compounds were characterized through 1H and 13C NMR and mass spectral studies.
Test-Retest Reliability of a Bilingual Arabic-English Pittsburgh Sleep Quality Index among Adolescents and Young Adults with Good or Poor Sleep Quality
Authors: Arumugam Ashokan , Mohammad Zadeh Shima A. , Alkalih Hanan Youssef , Zabin Zina Anwar , Hawarneh Tamara Mohd. Emad , Ahmed Hejab Iftikhar , Jauhari Fatema Shabbir , Al-Sharman Alham 
Published: April 2024

Abstract
Introduction The Pittsburg Sleep Quality Index (PSQI) is widely used in different population groups to assess self-reported sleep quality over the previous month. As the Arabic language is spoken by more than 400 million people, the PSQI has been translated into Arabic for its optimal application to Arabic-speaking individuals. However, the test-retest reliability of the Arabic version of the PSQI has not been reported yet.
Objective To examine the reliability and agreement of a bilingual Arabic-English version of the PSQI (AE-PSQI) among bilingual Arabic-English-speaking adolescents and young adults of the United Arab Emirates (UAE) with good or poor sleep quality.
Materials and Methods We included 50 bilingual Arabic-English-speaking adolescents and young adults (mean age of 20.82 ± 2.7 years; 30/50 subjects classified as poor sleepers [PSQI > 5] at baseline) who filled put the AE-PSQI twice, 7 days apart. The internal consistency of the AE-PSQI was assessed through the Cronbach's alpha. The intraclass correlation coefficient (ICC[3,1]) was used to assess the test-retest reliability. The standard error of measurement (SEM), the smallest real difference (SRD), and the Bland-Altman plots were used to report agreement measures.
Results The global score on the AE-PQSI showed an acceptable level of internal consistency with a Cronbach's alpha value of 0.65, and no floor and ceiling effects were observed. The 95% confidence intervals (95%CI: 0.63-0.87) of the ICC(3,1) revealed moderate to strong reliability estimates for overall AE-PSQI scores. The SEM and SRD were of 1.6 and 4.5 respectively, and the Bland-Altman plots revealed a moderate agreement between the baseline and retest global AE-PQSI scores.
Conclusion The AE-PSQI is a reliable instrument to assess sleep quality in bilingual Arabic-English-speaking adolescents and young adults with good or poor sleep quality. Further studies on the validity and responsiveness of the AE-PSQI are warranted in individuals with and without sleep disorders.
An Alternative In-Home Protocol to Diagnose and Treat Obstructive Sleep Apnea
Authors: Couto Patriota Tarcya L. G. , Pedrosa Rodrigo Pinto 
Published: April 2024

Abstract
Objective Obstructive sleep apnea (OSA) is a major public health problem of pandemic proportions. In-laboratory OSA diagnosis and continuous positive airway pressure (CPAP) titration are insufficient, considering the number of patients affected. Finding alternative ways to diagnose and treat OSA is mandatory, especially in this era of the coronavirus disease 2019 (COVID-19) pandemic. The present study aims to describe an alternative in-home protocol to diagnose and treat OSA.
Materials and Methods We enrolled consecutive patients aged ≥ 18 years with moderate/severe OSA, who underwent in-home type-III polysomnography and home-based titration with automatic CPAP, coupled with an oximetry sensor for 3 consecutive nights. Patients were remotely monitored for 90 days to evaluate CPAP compliance and the use of an engagement tool was encouraged.
Results We included 86 participants. The median time until the diagnosis was of one day. The mean time from the baseline visit until the acquisition and initiation of the CPAP therapy was of 33 (range: 17 to 52) days. Telemonitoring ensured good compliance in the first 30 (79.2%), 60 (76.3%) and 90 (74.3%) days, with an average daily use of 6.2 ± 1.4 h, 6.0 ± 1.4 h, and 6.0 ± 1.3 h respectively. About 1/3 of the patients used the engagement tool, and CPAP compliance was significantly higher among these patients compared with those who did not used the tool: 89.9% versus 73.5% (p < 0.002), 87.9% versus 70% (p < 0.003), and 86.6% versus 67.6% (p < 0.001) at 30, 60, and 90 days respectively.
Conclusion We demonstrated that an alternative in-home protocol to diagnose and treat OSA is effective, ensuring good CPAP compliance after 90 days. Telemonitoring and engagement tools could be strategies to improve CPAP compliance.
Fuzzy bounces
Authors: Giovannini Massimo 
Published: April 2024

Abstract
We observe that the energy and the enthalpy densities can be smeared by two fudge factors that are constrained by the contracted Bianchi identities. Depending on the analytic properties of the smearing functions the underlying cosmological solutions belong to two physically different classes, namely the bounces of the scale factor and the curvature bounces. While the curvature bounces are naturally compatible with a stage of accelerated expansion, the bounces of the scale factor demand an early phase of accelerated contraction even if a short inflationary stage may arise prior to the decelerated regime. Despite the regularity of the underlying solutions, gradient instabilities and singularities do occasionally appear in the evolution of curvature inhomogeneities. After deducing the specific criteria behind these occurrences, the background-independent conclusions are corroborated by a series of concrete examples associated with different forms of the smearing functions. The evolution of the curvature inhomogeneities restricts the ranges of the solutions that turn out to be unsuitable even for a limited description of the pre-inflationary initial data. The same observation holds in the case of the gauge-invariant evolution of the matter density contrast. It is however not excluded that a class of scenarios (mainly associated with the curvature bounces) could indeed avoid the potential instabilities. All in all the present analysis explore a general approach whose results are relevant in all the contexts where bouncing solutions are invoked either as complementary or as alternative to the conventional inflationary scenarios.
Gravitational wave pulse and memory effects for hairy Kiselev black hole and its analogy with Bondi–Sachs formalism
Authors: Hadi H , Rezaei Akbarieh Amin , Mota David F 
Published: April 2024

Abstract
The investigation of non-vacuum cosmological backgrounds containing black holes is greatly enhanced by the Kiselev solution. This solution plays a crucial role in understanding the properties of the background and its relationship with the features of the black hole. Consequently, the gravitational memory effects at large distances from the black hole offer a valuable means of obtaining information about the surrounding field parameter N and parameters related to the hair of the hairy Kiselev Black hole. This paper investigates the gravitational memory effects in the context of the Kiselev solution through two distinct approaches. At first, the gravitational memory effect at null infinity is explored by utilizing the Bondi–Sachs formalism by introducing a gravitational wave (GW) pulse to the solution. The resulting Bondi mass is then analyzed to gain further insight. Therefore, the Kiselev solution is being examined to determine the variations in Bondi mass caused by the pulse of GWs. The study of changes in Bondi mass is motivated by the fact that it is dynamic and time-dependent, and it measures mass on an asymptotically null slice or the densities of energy on celestial spheres. In the second approach, the investigation of displacement and velocity memory effects is undertaken in relation to the deviation of two neighboring geodesics and the deviation of their derivative influenced by surrounding field parameter N and the hair of hairy Kiselev black hole. This analysis is conducted within the context of a GW pulse present in the background of a hairy Kiselev black hole surrounded by a field parameter N.
A novel variational approach for multiphoton microscopy image restoration: from PSF estimation to 3D deconvolution
Authors: Ajdenbaum Julien , Chouzenoux Emilie , Lefort Claire , Martin Ségolène , Pesquet Jean-Christophe 
Published: April 2024

Abstract
In multi-photon microscopy (MPM), a recent in-vivo fluorescence microscopy system, the task of image restoration can be decomposed into two interlinked inverse problems: firstly, the characterization of the point spread function (PSF) and subsequently, the deconvolution (i.e. deblurring) to remove the PSF effect, and reduce noise. The acquired MPM image quality is critically affected by PSF blurring and intense noise. The PSF in MPM is highly spread in 3D and is not well characterized, presenting high variability with respect to the observed objects. This makes the restoration of MPM images challenging. Common PSF estimation methods in fluorescence microscopy, including MPM, involve capturing images of sub-resolution beads, followed by quantifying the resulting ellipsoidal 3D spot. In this work, we revisit this approach, coping with its inherent limitations in terms of accuracy and practicality. We estimate the PSF from the observation of relatively large beads (approximately 1

μ

m

in diameter). This goes through the formulation and resolution of an original non-convex minimization problem, for which we propose a proximal alternating method along with convergence guarantees. Following the PSF estimation step, we then introduce an innovative strategy to deal with the high level multiplicative noise degrading the acquisitions. We rely on a heteroscedastic noise model for which we estimate the parameters. We then solve a constrained optimization problem to restore the image, accounting for the estimated PSF and noise, while allowing a minimal hyper-parameter tuning. Theoretical guarantees are given for the restoration algorithm. These algorithmic contributions lead to an end-to-end pipeline for 3D image restoration in MPM, that we share as a publicly available Python software. We demonstrate its effectiveness through several experiments on both simulated and real data.
Cross sections of neutral-current neutrino scattering on 98,100Mo isotopes
Authors: Sahu R , Kota V K B , Kosmas T S 
Published: April 2024

Abstract
Coherent elastic neutrino–nucleus scattering (CEνNS) is a neutral-current low-energy electro-weak reaction-channel detected recently by the COHERENT experiment at the Oak Ridge National Laboratory (ORNL), USA, in the Spallation Neutron Source facility. The extremely weak signal on the CsI detector of the first experiment and on the liquid Ar of the repeated COHERENT experiment is the energy-recoil due to the neutrino–nucleus interaction, where the nucleus is elastically scattered as a whole while simultaneously the neutrino goes out. Today, several promising nuclear detectors are on the way to be employed in designed and ongoing experiments. In our present work, we provide predictions for incoherent scattering cross sections of low-energy neutrinos on 98,100Mo isotopes obtained with the deformed shell model employed previously for similar predictions in other electroweak processes. We mention that, Mo detector medium has been used previously in the MOON and NEMO double beta decay experiments.