bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of pharmacist in community palliative care—a scoping review
Authors: Thrimawithana Thilini R , Spence Meredith , Lee Madison , Naysoe Nancy , Hanna Shereen , Yako Ghaith , Goma Stan , Stupans Ieva , Lim Chiao Xin 
Published: April 2024

Abstract

Objectives
Dynamic and adaptive services that provide timely access to care are pivotal to ensuring patients with palliative needs experience high-quality care. Patients who have palliative care needs may require symptomatic relief with medicines and, therefore, may engage with community pharmacists frequently. However, there is limited evidence for pharmacists’ involvement in community palliative care models. Therefore, a scoping review was conducted to identify pharmacists’ role in community palliative care.

Methods
A systematic search strategy was implemented across PubMed, PsychINFO, CINAHL, and Embase databases. Articles were screened by abstract and full text against inclusion and exclusion criteria.

Key findings
Five articles (two from Australia, two from England, and one from Scotland) met the inclusion criteria and described interventions involving pharmacists in community palliative care. This review has identified that the inclusion of trained pharmacists in community palliative care teams can improve the quality of care provided for patients with palliative needs. Pharmacists are able to undertake medication reviews and provide education to patients and other healthcare professionals on the quality use of palliative care medicines. Additionally, the underutilization of community pharmacists in palliative care, the need for further training of pharmacists, and improved community pharmacy access to patient information to deliver community palliative care were identified.

Conclusion
Pharmacists can play a vital role in community palliative care to enhance the quality of life of patients. There is a need for greater pharmacist education/training, improved interprofessional communication, improved access to patient information and sustainable funding to strengthen community-based palliative care.
Existence of solution for an optimal control problem in a heterogeneous porous medium
Authors: Kundu A , Mahato H S 
Published: April 2024

Abstract
The paper explores an optimal control problem concerning transport processes in a porous medium. The transport phenomena is governed by diffusion-reaction equations, which is basically a semi-linear parabolic system. An $L^{2}$-cost (energy) functional is introduced, and control (distributed) is applied in the porous part of the medium. The primary objective is to characterize a given control to be an optimal control and analyse the relationship between optimal control and the adjoint state. The analysis commences with the microscopic description of the controlled system followed by upscaling the system via periodic homogenization.
Duality in the Directed Landscape and Its Applications to Fractal Geometry
Authors: Bhatia Manan 
Published: April 2024

AbstractGeodesic coalescence, or the tendency of geodesics to merge together, is a hallmark phenomenon observed in a variety of planar random geometries involving a random distortion of the Euclidean metric. As a result of this, the union of interiors of all geodesics going to a fixed point tends to form a tree-like structure that is supported on a vanishing fraction of the space. Such geodesic trees exhibit intricate fractal behaviour; for instance, while almost every point in the space has only one geodesic going to the fixed point, there exist atypical points that admit two such geodesics. In this paper, we consider the directed landscape, the recently constructed [ 18] scaling limit of exponential last passage percolation (LPP), with the aim of developing tools to analyse the fractal aspects of the tree of semi-infinite geodesics in a given direction. We use the duality [ 39] between the geodesic tree and the interleaving competition interfaces in exponential LPP to obtain a duality between the geodesic tree and the corresponding dual tree in the landscape. Using this, we show that problems concerning the fractal behaviour of sets of atypical points for the geodesic tree can be transformed into corresponding problems for the dual tree, which might turn out to be easier. In particular, we use this method to show that the set of points admitting two semi-infinite geodesics in a fixed direction a.s. has Hausdorff dimension $4/3$, thereby answering a question posed in [ 12]. We also show that the set of points admitting three semi-infinite geodesics in a fixed direction is a.s. countable.
The fractional free convolution of R-diagonal elements and random polynomials under repeated differentiation
Authors: Campbell Andrew , O’Rourke Sean , Renfrew David 
Published: April 2024

Abstract
We extend the free convolution of Brown measures of $R$-diagonal elements introduced by Kösters and Tikhomirov [ 28] to fractional powers. We then show how this fractional free convolution arises naturally when studying the roots of random polynomials with independent coefficients under repeated differentiation. When the proportion of derivatives to the degree approaches one, we establish central limit theorem-type behavior and discuss stable distributions.
Montelukast and cefoperazone act as antiquorum sensing and antibiofilm agents against Pseudomonas aeruginosa
Authors: Vieira Tatiana F , Leitão Miguel M , Cerqueira Nuno M F S A , Sousa Sérgio F , Borges Anabela , Simões Manuel 
Published: April 2024

Abstract

Aims
Drug repurposing is an attractive strategy to control biofilm-related infectious diseases. In this study, two drugs (montelukast and cefoperazone) with well-established therapeutic applications were tested on Pseudomonas aeruginosa quorum sensing (QS) inhibition and biofilm control.

Methods and results
The activity of montelukast and cefoperazone was evaluated for Pqs signal inhibition, pyocyanin synthesis, and prevention and eradication of Ps. aeruginosa biofilms. Cefoperazone inhibited the Pqs system by hindering the production of the autoinducer molecules 2-heptyl-4-hydroxyquinoline (HHQ) and 2-heptyl-3-hydroxy-4(1H)-quinolone (the Pseudomonas quinolone signal or PQS), corroborating in silico results. Pseudomonas aeruginosa pyocyanin production was reduced by 50%. The combination of the antibiotics cefoperazone and ciprofloxacin was synergistic for Ps. aeruginosa biofilm control. On the other hand, montelukast had no relevant effects on the inhibition of the Pqs system and against Ps. aeruginosa biofilm.

Conclusion
This study provides for the first time strong evidence that cefoperazone interacts with the Pqs system, hindering the formation of the autoinducer molecules HHQ and PQS, reducing Ps. aeruginosa pathogenicity and virulence. Cefoperazone demonstrated a potential to be used in combination with less effective antibiotics (e.g. ciprofloxacin) to potentiate the biofilm control action.
Synergistic interactions of essential oil components with antibiotics against multidrug-resistant Corynebacterium striatum
Authors: Yilmaz Umut , Coşkun Ahmet Gökhan , Özel Yener , Ünlü Mehmet , Vardar-ünlü Gülhan 
Published: April 2024

Abstract

Aim
In this study, it was aimed to examine the antibacterial activity of the essential oil components (EOCs), carvacrol (CAR), cinnamaldehyde (CIN), thymol (TH), alpha pinene (α-PN), eucalyptol (EU), limonene (LIM), and the antibiotics, linezolid (LZD), vancomycin (VAN), gentamicin (GEN), ciprofloxacin (CIP), clindamycin (CLN), and penicillin (PEN) against 50 multidrug resistant Corynebacterium striatum strains, and the synergistic interactions of CAR and CIN with the antibiotics against 10 randomly selected Coryne. striatum strains to explore synergistic interactions to determine if their combined use could enhance antibiotic activity and potentially reduce resistance.

Methods and results
The activity of the EOCs and the antibiotics against Coryne. striatum strains isolated from clinical specimens, was examined by broth microdilution method. The synergistic interactions of the EOCs with the antibiotics against 10 randomly selected Coryne. striatum strains were determined by checkerboard method. EOCs, CIN, and CAR and antibiotics, LZD, VAN, GEN, CIP, and CLN were detected to have antibacterial activity against Coryne. striatum strains alone and either synergistic interactions were observed in combinations of the antibiotics with EOCs.

Conclusions
All Coryne. striatum strains were determined to be susceptible to VAN and LZD and resistant to GEN, PEN, CIP, and CLN. Synergistic interactions were observed in all combinations of antibiotics tested with CAR and CIN.
Pleomorphic adenoma gene1 in reproduction and implication for embryonic survival in cattle: a review
Authors: D’Occhio Michael J , Campanile Giuseppe , Baruselli Pietro S , Porto Neto Laercio R , Hayes Ben J , Snr Alf Collins , Fortes Marina R S 
Published: April 2024

Abstract
The pleomorphic adenoma gene1 (PLAG1) encodes a DNA-binding, C2H2 zinc-finger protein which acts as a transcription factor that regulates the expression of diverse genes across different organs and tissues; hence, the name pleomorphic. Rearrangements of the PLAG1 gene, and/or overexpression, are associated with benign tumors and cancers in a variety of tissues. This is best described for pleomorphic adenoma of the salivary glands in humans. The most notable expression of PLAG1 occurs during embryonic and fetal development, with lesser expression after birth. Evidence has accumulated of a role for PLAG1 protein in normal early embryonic development and placentation in mammals. PLAG1 protein influences the expression of the ike growth factor 2 (IGF2) gene and production of IGF2 protein. IGF2 is an important mitogen in ovarian follicles/oocytes, embryos, and fetuses. The PLAG1-IGF2 axis, therefore, provides one pathway whereby PLAG1 protein can influence embryonic survival and pregnancy. PLAG1 also influences over 1,000 other genes in embryos including those associated with ribosomal assembly and proteins. Brahman (Bos indicus) heifers homozygous for the PLAG1 variant, rs109815800 (G &gt; T), show greater fertility than contemporary heifers with either one, or no copy, of the variant. Greater fertility in heifers homozygous for rs109815800 could be the result of early puberty and/or greater embryonic survival. The present review first looks at the broader roles of the PLAG1 gene and PLAG1 protein and then focuses on the emerging role of PLAG1/PLAG1 in embryonic development and pregnancy. A deeper understanding of factors which influence embryonic development is required for the next transformational increase in embryonic survival and successful pregnancy for both in vivo and in vitro derived embryos in cattle.
Burn Wounds and Enzymatic Debridement (ED)—Past, Present, and Future
Authors: Atiyeh Bishara , Makkawi Kareem , Beaineh Paul 
Published: April 2024

Abstract

Introduction
Excision of necrotic and devitalized tissues of deep burns is key for optimal care of burn injuries. However, the modality of early tangential excision followed by skin grafting proposed by Zora Janzekovic 5 decades ago was not received initially with great enthusiasm. At present, it developed to become the standard of care (SOC) despite the special expertise it necessitates and the general anesthesia it requires in addition to several drawbacks including excessive blood loss, risk of hypothermia, and most importantly potential excision of normal non-burned tissues. Conservative non-surgical selective enzymatic debridement (ED) at present is becoming more popular as an adjunct or even an alternative approach.

Methods
A systematic review of the PubMed electronic database was conducted to identify all experimental and clinical studies about ED of burn wounds. Additional separate searches were also conducted to identify any reports missed by the initial systematic review. Full texts of 59 reports (42 clinical and 17 experimental studies) were retrieved for analysis.

Results
A total of 46 studies (11 experimental and 35 clinical) were about the pineapple extract debriding agent. In total, 23 clinical studies describing promising favorable results with pineapple bromelain-based debridement (BBD) concentrate were published in the last 3 years (2020-2023).

Conclusion
Though available evidence is not entirely in favor of replacing the current surgical SOC with BBD, it certainly presents ED as a highly advantageous modality for the management of burn wounds. Newly described keratinase and SN514 also are promising new products. They both still await further investigation before being clinically adopted.
Current trends for venous thromboembolic prophylaxis for hip arthroscopy: a modified Delphi and nominal group technique consensus study
Authors: Parsa Ali , Bedi Asheesh , Domb Benjamin G 
Published: April 2024

ABSTRACT
The overall risk of venous thromboembolism (VTE) after hip arthroscopy (HA) is reported to range from 0.2% to 9.5%, but a clear set of recommendations for VTE prophylaxis in HA patients remains scarce. The aim is to survey high-volume hip arthroscopists about their current trends regarding VTE prophylaxis use. A combination of two consensus group methods was used in this study: nominal group technique (NGT) and modified Delphi. A preliminary questionnaire was prepared, and rounds of discussion were completed between NGT members. The final version of the survey was administered to 35 high-volume hip surgeons. Delegates’ mean volume of annual hip arthroscopic surgery was 109. Approximately 22% of their patients are revision HA procedures. A total of 91.4% of delegates use chemoprophylaxis, 28.6% use sequential compression devices and 91.4% believed that chemoprophylaxis is necessary for more prolonged and complex procedures (strong consensus). Aspirin was the choice for all participants, and the duration was 2–3 weeks (31.4%), 1 month (65.7%) and 2–3 months (2.9%). History of VTE, hypercoagulable status, and malignancy were considered risk factors. No consensus was achieved for the discontinuation of oral contraceptive and smoking preoperatively. However, the optimal length of VTE prophylaxis is unclear. A total of 97.1% of the experts responded that they administer aspirin between 2 and 4 weeks. High-volume arthroscopic surgeons do consider VTE prophylaxis to be important and warranted in the postoperative setting. Aspirin is the mainstay of chemoprophylaxis, although the appropriate duration is unknown.
Profile of Duponchelia fovealis (Lepidoptera: Crambidae) as a greenhouse and nursery pest in the United States
Authors: Copeman Sophia M , Frank Steven D 
Published: April 2024

Abstract
Duponchelia fovealis (Zeller) (Lepidoptera: Crambidae) is a pest native to Southern Europe and the Eastern Mediterranean that has become invasive in many other parts of the world including the United States. This polyphagous pest infests many ornamental plants, fruit and vegetable crops, cut flowers, and some aquatic plants. In the United States, it is mainly a pest in greenhouses and outdoor nurseries. Data on D. fovealis are limited, and there is no solid information on effective integrated pest management (IPM) strategies. A review of pest distribution and pest status, host plants, nature of pest injury, description of life stages, biology and ecology, and management options for D. fovealis is presented. We also highlight areas of research that will improve IPM.
Inhibition of GLUD1 mediated by LASP1 and SYVN1 contributes to hepatitis B virus X protein-induced hepatocarcinogenesis
Authors: You Hong-Juan , Li Qi , Ma Li-Hong , Wang Xing , Zhang Huan-Yang , Wang Yu-Xin , Bao En-Si , Zhong Yu-Jie , Kong De-Long , Liu Xiang-Ye , Kong Fan-Yun , Zheng Kui-Yang , Tang Ren-Xian 
Published: April 2024

AbstractGlutamate dehydrogenase 1 (GLUD1) is implicated in oncogenesis. However, little is known about the relationship between GLUD1 and hepatocellular carcinoma (HCC). In the present study, we demonstrated that the expression levels of GLUD1 significantly decreased in tumors, which was relevant to the poor prognosis of HCC. Functionally, GLUD1 silencing enhanced the growth and migration of HCC cells. Mechanistically, the upregulation of interleukin-32 through AKT activation contributes to GLUD1 silencing-facilitated hepatocarcinogenesis. The interaction between GLUD1 and AKT, as well as α-ketoglutarate regulated by GLUD1, can suppress AKT activation. In addition, LIM and SH3 protein 1 (LASP1) interacts with GLUD1 and induces GLUD1 degradation via the ubiquitin–proteasome pathway, which relies on the E3 ubiquitin ligase synoviolin (SYVN1), whose interaction with GLUD1 is enhanced by LASP1. In hepatitis B virus (HBV)-related HCC, the HBV X protein (HBX) can suppress GLUD1 with the participation of LASP1 and SYVN1. Collectively, our data suggest that GLUD1 silencing is significantly associated with HCC development, and LASP1 and SYVN1 mediate the inhibition of GLUD1 in HCC, especially in HBV-related tumors.
Evaluating colonoscopy quality by performing provider type
Authors: Berry Emily , Hostetter Jeff , Bachtold Joseph , Zamarripa Sarah , Argenbright Keith E 
Published: April 2024

Abstract

Background
Colorectal cancer is the third most diagnosed cancer and the second leading cause of cancer death in the United States. Colonoscopy is an essential tool for screening, used as a primary approach and follow-up to an abnormal stool-based colorectal cancer screening result. Colonoscopy quality is often measured with 4 key indicators: bowel preparation, cecal intubation, mean withdrawal time, and adenoma detection. Colonoscopies are most often performed by gastroenterologists (GI), however, in rural and medically underserved areas, non-GI providers often perform colonoscopies. This study aims to evaluate the quality and safety of screening colonoscopies performed by non-GI practitioner, comparing their outcomes with those of GI providers.

Methods
Descriptive statistics were used to characterize the study population. Results for quality indicators were stratified by provider type and compared. Statistical significance was determined using a P value of less than .05 as the threshold for all comparisons; all P values were 2-sided.

Results
No statistical difference was found when comparing performance by provider type. Median performance for gastroenterologists, general surgeons, and family medicine providers ranged from 98% to 100% for cecal intubation; 97.4% to 100% for bowel preparation; 57.4% to 88.9% for male adenoma detection rate; 47.7% to 62.13% for female adenoma detection rate; and 0:12:10 to 0:20:16 for mean withdrawal time. All provider types met and exceeded the goal metric for each of the quality indicators (P &lt; .001).

Conclusions
As a result of this analysis, we can expect non-GI practitioner to perform colonoscopies with similar quality to GI practitioner given the performance outcomes for the key quality metrics.
Housing assistance among patients with cancer: SEER-Medicare US Department of Housing and Urban Development data linkage
Authors: Pollack Craig Evan , Garrison Veronica , Johnson Taylor , Blackford Amanda L , Banks Bob , Howe William , Yabroff K Robin , Enewold Lindsey 
Published: April 2024

Abstract

Background
Lack of stable, affordable housing is an important social determinant of health. Federal housing assistance may buffer against housing vulnerabilities among low-income households, but research examining the association of housing assistance and cancer care has been limited. We introduce a new linkage of Surveillance, Epidemiology, and End Results (SEER) program-Medicare and US Department of Housing and Urban Development (HUD) administrative data.

Methods
Individuals enrolled in HUD public and assisted housing programs between 2006 and 2021 were linked with cancer diagnoses between 2006 and 2019 identified in the SEER-Medicare data from 16 states using Match*Pro (National Institutes of Health, Bethesda, MD) probabilistic linkage software. HUD administrative data include timing and type of housing assistance as well as verified household income. Medicare administrative data are available through 2020.

Results
A total of 335 490 unique individuals who received housing assistance at any time point, including 156 794 who received housing assistance around the time of their diagnosis (at least 6 months before diagnosis until 6 months after diagnosis or death), were matched to SEER-Medicare data. A total of 63 251 individuals receiving housing assistance at the time of their diagnosis were aged 66 years and older and continuously enrolled in Medicare parts A and B fee for service; 12 035 had a diagnosis of lung cancer, 8866 of breast cancer, 7261 of colorectal cancer, and 4703 of prostate cancer.

Conclusions
This novel data linkage will be available through the National Cancer Institute and can be used to explore the ways in which housing assistance is associated with cancer diagnosis, care, and outcomes, including the role of housing assistance status in potentially reducing or contributing to inequities across racialized and ethnic groups.
The Maintain High Blood Glucose subscale of the child hypoglycemia fear survey: proposed preliminary cut points for screening youth with type 1 diabetes
Authors: O’Donnell Holly K , Johnson Suzanne Bennett , Driscoll Kimberly A 
Published: April 2024

Abstract

Objective
To improve the clinical utility of the Maintain High Blood Glucose subscale of the Hypoglycemia Fear Surveys (HFS) by identifying clinically meaningful cut points associated with glycemic outcomes.

Methods
Youth (N = 994; 13.96 ± 2.3 years) with type 1 diabetes and their caregivers (N = 1,111; 72% female) completed the Child or Parent version of the HFS. Modal Score Distribution, Standard Deviation Criterion, and Elevated Item Criterion approaches were used to identify proposed preliminary cut points for the Maintain High Blood Glucose subscale. The association between proposed preliminary cut points was examined with youth glycemic outcomes.

Results
A cut point of ≥7 for the Maintain High Blood Glucose subscale on the Child HFS was associated with a greater percentage of blood glucose readings &gt;180 mg/dl (p &lt; .01), higher mean blood glucose (p &lt; .001), and a higher hemoglobin A1c (p &lt; .05). In subsequent multiple regression analyses, controlling for other factors associated with glycemia, the significant association between scores above ≥7 and higher mean blood glucose and higher hemoglobin A1c remained. A clinically useful cut point was not identified for caregivers. However, elevated youth scores on the Maintain High Blood Glucose subscale were positively associated with elevated caregiver scores (phi = .171, p &lt; .001).

Conclusions
The proposed preliminary cut point for the Maintain High Blood Glucose subscale will aid the type 1 diabetes care team in identifying youth whose behaviors may be contributing to their suboptimal glycemia.
“Where Did This Come From?”: Antibiotic Prophylaxis in Biliary Atresia After Kasai Procedure
Authors: Ravanbakhsh Naseem , Chapin Catherine A , Li Yun , Jhaveri Ravi 
Published: April 2024

Abstract
For patients with Biliary atresia, antibiotic prophylaxis after Kasai portoenterostomy is a common practice. Societal guidelines often cite one reference as supportive evidence for this practice. In this paper, we go back to review the quality of this evidence and suggest more research is required to demonstrate the efficacy of antibiotic prophylaxis in this population.