bluuebunny/crossref_metadata_2025_split huggingface dataset:
Triple‐negative breast cancer survival prediction using artificial intelligence through integrated analysis of tertiary lymphoid structures and tumor budding
Authors: Hou Xupeng , Li Xueyang , Han Yunwei , Xu Hua , Xie Yongjie , Zhou Tianxing , Xue Tongyuan , Qian Xiaolong , Li Jiazhen , Wang Hayson Chenyu , Yan Jingrui , Guo Xiaojing , Liu Ying , Liu Jing 
Published: February 2024

AbstractBackgroundTriple‐negative breast cancer (TNBC) is a highly heterogeneous and clinically aggressive disease. Accumulating evidence indicates that tertiary lymphoid structures (TLSs) and tumor budding (TB) are significantly correlated with the outcomes of patients who have TNBC, but no integrated TLS‐TB profile has been established to predict their survival. The objective of this study was to investigate the relationship between the TLS/TB ratio and clinical outcomes of patients with TNBC using artificial intelligence (AI)‐based analysis.MethodsThe infiltration levels of TLSs and TB were evaluated using hematoxylin and eosin staining, immunohistochemistry staining, and AI‐based analysis. Various cellular subtypes within TLS were determined by multiplex immunofluorescence. Subsequently, the authors established a nomogram model, conducted calibration curve analyses, and performed decision curve analyses using R software.ResultsIn both the training and validation cohorts, the antitumor/protumor model established by the authors demonstrated a positive correlation between the TLS/TB index and the overall survival (OS) and relapse‐free survival (RFS) of patients with TNBC. Notably, patients who had a high percentage of CD8‐positive T cells, CD45RO‐positive T cells, or CD20‐positive B cells within the TLSs experienced improved OS and RFS. Furthermore, the authors developed a comprehensive TLS‐TB profile nomogram based on the TLS/TB index. This novel model outperformed the classical tumor‐lymph node‐metastasis staging system in predicting the OS and RFS of patients with TNBC.ConclusionsA novel strategy for predicting the prognosis of patients with TNBC was established through integrated AI‐based analysis and a machine‐learning workflow. The TLS/TB index was identified as an independent prognostic factor for TNBC. This nomogram‐based TLS‐TB profile would help improve the accuracy of predicting the prognosis of patients who have TNBC.
Optimization of a flow cytometry test for routine monitoring of B cell maturation antigen targeted CAR in peripheral blood
Authors: Lee Won‐Ho , Graham Charlotte E. , Wiggin Hadley R. , Nolan Hannah K. , Graham Kiana J. , Korell Felix , Leick Mark B. , Barselau Alexis L. , Emmanuel‐Alejandro Estelle , Trailor Michael A. , Gildea Juliane M. , Preffer Frederic , Frigault Matthew J. , Maus Marcela V. , Gallagher Kathleen M. E. 
Published: February 2024

AbstractChimeric antigen receptor (CAR) modified T cell therapies targeting BCMA have displayed impressive activity in the treatment of multiple myeloma. There are currently two FDA licensed products, ciltacabtagene autoleucel and idecabtagene vicleucel, for treating relapsed and refractory disease. Although correlative analyses performed by product manufacturers have been reported in clinical trials, there are limited options for reliable BCMA CAR T detection assays for physicians and researchers looking to explore it as a biomarker for clinical outcome. Given the known association of CAR T cell expansion kinetics with toxicity and response, being able to quantify BCMA CAR T cells routinely and accurately in the blood of patients can serve as a valuable asset. Here, we optimized an accurate and sensitive flow cytometry test using a PE‐conjugated soluble BCMA protein, with a lower limit of quantitation of 0.19% of CD3+ T cells, suitable for use as a routine assay for monitoring the frequency of BCMA CAR T cells in the blood of patients receiving either ciltacabtagene autoleucel or idecabtagene vicleucel.
Mechanistic Insights into Urea‐, Thiourea‐, and Isothiourea‐Based Bifunctional Tetraarylphosphonium Salt Catalysis for Conversion of Carbon Dioxide to Cyclic Carbonates
Authors: Toda Yasunori , Suenaga Daiki , Yamaguchi Ren , Suga Hiroyuki 
Published: February 2024

AbstractA novel bifunctional isothiourea derived from a tetraarylphosphonium salt catalyzes the coupling reaction of monosubstituted epoxides with 1 atm of carbon dioxide to afford five‐membered cyclic carbonates in high yields. Thiourea and urea groups are also effective hydrogen bond donors for the carbon dioxide fixation. Comprehensive mechanistic studies on this catalysis using theoretical calculations disclosed key hydrogen bond interactions between catalysts and intermediates, which relied upon orientation of the binding modes.
Acute encephalopathy with biphasic seizures and late reduced diffusion with concurrent transverse myelitis
Authors: Austin‐Keiller Amanda , Saint‐Martin Christine , Myers Kenneth A. 
Published: February 2024

AbstractWe describe a patient with acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) with unique features, including concurrent transverse myelitis. A 2‐year‐old previously healthy girl had clinical findings consistent with AESD, occurring in association with influenza A infection. The posterior brain regions were most severely affected, resulting in cortical blindness. She also developed bilateral limb weakness, and spine MRI revealed transverse myelitis in the cervical region. She was treated acutely with intravenous methylprednisolone. Serum anti‐myelin oligodendrocyte glycoprotein and anti‐aquaporin‐4 antibodies were negative, as was an anti‐extractable nuclear antigen panel. Although her clinical presentation was severe, she improved dramatically over the following months, and 6 months following initial presentation, her parents felt she had returned to baseline. This is the first report of AESD occurring in combination with transverse myelitis. The co‐occurrence of the two conditions is unlikely to be coincidental, suggesting that there may be a shared or overlapping immunological pathway involved. The patient's recovery was impressive, which could partially relate to the acute treatment with corticosteroids.
Improving demand forecasting for customers with missing downstream data in intermittent demand supply chains with supervised multivariate clustering
Authors: Ducharme Corey , Agard Bruno , Trépanier Martin 
Published: February 2024

AbstractIn a collaborative supply chain arrangement like vendor‐managed inventory, information on product demand at the point of sale is expected to be shared among members of the supply chain. However, in practice, obtaining such information can be costly, and some members may be unwilling or unable to provide the necessary access to the data. As such, large collaborative supply chains with multiple members may operate under a mixed‐information scenario where point‐of‐sale demand information is not known for all customers. Other sources of demand information exist and are becoming more available along supply chains using Industry 4.0 technologies and can serve as a substitute, but the data may be noisy, distorted, and partially missing. Under mixed information, leveraging existing customers' point‐of‐sale demand to improve the intermittent demand forecast of customers with missing information has yet to be explored. We propose a supervised demand forecasting method that uses multivariate time series clustering to map multiple sources of demand data. Members with missing downstream demand data have their resulting demand forecast improved by averaging over customers with similar delivery patterns for their final demand forecast. Our results show up to a 10% accuracy improvement over traditional intermittent demand forecasting methods with missing information.
PSF‐Radon transform algorithm: Measurement of the point‐spread function from the Radon transform of the line‐spread function
Authors: Martínez Sandra , Martínez Oscar E. 
Published: February 2024

AbstractIn this article, we present a new method called point spread function (PSF)‐Radon transform algorithm. This algorithm consists on recovering the instrument PSF from the Radon transform (in the line direction axis) of the line spread function (i.e., the image of a line). We present the method and tested with synthetic images, and real images from macro lens camera and microscopy. A stand‐alone program along with a tutorial is available, for any interested user, in Martinez (PSF‐Radon transform algorithm, standalone program).Research Highlights
Determining the instrument PSF is a key issue.
Precise PSF determinations are mandatory if image improvement is performed numerically by deconvolution.
Much less exposure time to achieve the same performance than a measurement of the PSF from a very small bead.
Does not require having to adjust the PSF by an analytical function to overcome the noise uncertainties.
Consistency in human papillomavirus type detection between self‐collected vaginal specimens and physician‐sampled cervical specimens
Authors: Chou Hung‐Hsueh , Yang Chung‐Yao , Chao Angel , Lin Hao , Lu Chien‐Hsing , Ou Yu‐Che , Hsu Shih‐Tien , Shih Yu‐Hsiang , Huang Huei‐Jean , Lin Cheng‐Tao , Chen Min‐Yu , Sun Lou , Tsai Ching‐Chou , Fu Hung‐Chun , Huang Kuan‐Gen , Wu Kai‐Yun , Wu Chen‐Hsuan , Hsieh Wu‐Chiao , Huang Yi‐Ting , Chen Liang‐Hsuan , Yang Lan‐Yan , Chang Wei‐Yang , Chang Ting‐Chang , Lai Chyong‐Huey 
Published: February 2024

AbstractWith the rising need for accessible cervical cancer screening, self‐sampling methods offer a promising alternative to traditional physician‐led sampling. This study aims to evaluate the efficacy of the HygeiaTouch Self Sampling Kit for Women in detecting human papillomavirus (HPV) types and predicting cervical lesions. We studied the concordance in identifying high‐risk HPV (hrHPV) types between samples collected by physicians and those self‐collected by women using a self‐sampling kit for validation. Women aged 21–65, fitting into specific categories based on their cervical health history were eligible. Cohen's kappa coefficient to gauge concordance between the two specimen types and relative accuracy metrics in identifying cervical intraepithelial neoplasia (CIN) were also calculated, with physician‐sampled specimens serving as a reference. A total of 1210 participants from three institutes were involved. The self‐sampling kit closely matched the physician‐led method in terms of collecting valid specimens (100% vs. 100%), identifying hrHPV types (kappa: 0.75, 95% confidence interval [95% CI]: 0.72–0.79; agreement: 87.7%, 95% CI: 85.8–89.6) and predicting CIN grade 2 or worse (CIN2+) (relative sensitivity: 0.949, relative accuracy: 0.959). Kappa values varied between 0.71 and 0.83 for different hrHPV types and combinations, with an overall value 0.75 (95% CI: 0.72–0.79) signifying robust compatibility between the two methods. Our study underscores the potential of the HygeiaTouch Self Sampling Kit as a reliable, efficient, and user‐friendly alternative to traditional sampling methods. This suggests that self‐sampling could be pivotal in expanding cervical cancer screening accessibility and enhancing detection rates.
Promotion focus is valued in men more than in women
Authors: Gutermuth Dinah , Hamstra Melvyn R. W. 
Published: February 2024

SummaryIn this research, we test the hypothesis that promotion‐focused eagerness does not yield the same evaluative benefits in the workplace for women as it does for men. Regulatory focus theory suggests that promotion‐focused eagerness potentially casts a person in a favorable light in the eyes of superiors. Nevertheless, we propose that promotion‐focused eagerness violates the prescriptive gender‐stereotypical expectations that people have of women. The gender deviance (i.e., not acting in line with gender expectations) that occurs when a woman is promotion‐focused causes this woman to pay a “gender tax” that a promotion‐focused man does not pay. First, we conducted two experiments wherein managers (N = 127) or students (N = 236) evaluated qualified fictional job applicants: in both experiments, compared with an identical male applicant, the promotion‐focused female job applicant was valued less, as evidenced by a lower starting salary offer. Second, in a dyadic study (N = 474 dyads), male employees' promotion focus was positively associated with their manager's evaluations of them, whereas female employees' promotion focus was not. Our results show that promotion‐focused women are not valued as positively as their male counterparts.
Multimodel comparison and assessment of short to medium range precipitation and temperature forecasts over India: Implications towards forecasting of meteorological indices in India
Authors: Saminathan Sakila , Mitra Subhasis , Singh Sarmistha , Mandal Raju , Joseph Susmitha 
Published: February 2024

AbstractA comprehensive assessment of the forecast skill of various meteorological indices over the Indian region from different numerical weather prediction (NWP) models is lacking in the literature. In this study the performance of four NWP models, namely Global Ensemble Forecast System (GEFSv12), European Center for Medium Range Forecasting (ECMWF), Climate Forecast System (CFSv2) and Indian Institute of Tropical Meteorology (IITM) towards forecasting of precipitation, temperature and associated meteorological indices, is evaluated at short to medium timescales across the Indian region. Further, the effect of ocean atmospheric (OA) oscillations on the precipitation/temperature forecast skill from the different NWP models is also assessed. Results show that the NWP models are better in predicting the meteorological indices than the quantitative forecasts. The ECMWF model was found to be the best for PCP forecasting with CFSv2 performing poorly. For temperature the GEFSv12 model performance was the lowest, compared to rest of the models. The models show poor skill in forecasting monsoon season precipitation compared to non‐monsoon and the temperature forecasts from the NWP models are particularly poor for the northern basins. Skilful temperature forecasts are observed in the Northwestern, Indo‐Gangetic and Central basins for the CFSv2 and ECMWF models. The forecast skill of precipitation indices are higher in the northwestern, central and Indo‐Gangetic basins compared to the rest. The skill of precipitation indices, namely rainy days, extreme rainy days and consecutive wet days, is higher during the monsoon seasons while the prediction skill of consecutive dry days is higher during the non‐monsoon season. OA analysis revealed that the ENSO phases have dominant effect on the forecast skill of the precipitation only. The temperature and meteorological indices forecasts are not affected significantly by the OA phases. The outcomes of this study have implications towards irrigation scheduling and water resources management decision making in India.
Global knee function rating more strongly influences adolescent athletes that sustain a sports‐related surgical ACL re‐injury or contralateral ACL injury
Authors: Nyland John , Tomberlin Colson , Brey Jennifer , Carter Sam 
Published: February 2024

AbstractPurposeThis study evaluated differences between adolescent athletes who sustained a surgical anterior cruciate ligament (ACL) re‐injury, or contralateral ACL injury following return to sports bridge programme participation (Group 1) compared to those that did not (Group 2).MethodsAt 19.9 ± 7 years of age, 198 athletes participated in this study. Groups were compared for time postsurgery, preprogramme and postprogramme Knee Outcome Survey Sports Activity Scale (KOS‐SAS) and global rating of knee function (GRKF) during sports activities, postprogramme lower extremity physical function test performance and perceived sports performance compared to preinjury level.ResultsBy 6.0 ± 3.2 years postsurgery, 11 (5.6%) sustained another ACL injury. Group 1 was younger (17.3 ± 1.7 years vs. 20.1 ± 6.8 years, p < 0.001). Postprogramme re‐evaluation revealed that Group 1 had a greater GRKF compared to their programme initiation GRKF than Group 2 (32.6 ± 38 vs. 20.0 ± 23, p = 0.04). Group 1 also had a greater mean preprogramme to postprogramme GRKF change than Group 2 (51.3 ± 31 vs. 35.5 ± 21, p = 0.02) (effect size = 0.73). More Group 1 subjects also had a GRKF difference that exceeded the overall mean than Group 2 (p = 0.04). Group 1 had moderately strong relationships between preprogramme and postprogramme GRKF score change and the postprogramme GRKF score (r = 0.65, p = 0.04) and between preprogramme and postprogramme KOS‐SAS score change and postprogramme GRKF score (r = 0.60, p = 0.04).ConclusionGlobal rating scores had a stronger influence among adolescent athletes that sustained either surgical ACL re‐injury or contralateral ACL injury. Since group physical function and neuromuscular control factors were similar, clinicians need to increase their awareness and understanding of other factors that may influence surgical ACL re‐injury or contralateral ACL injury risk.Level of EvidenceLevel III, retrospective cohort study.
Vitamin C Inhibited Pulmonary Metastasis through Activating Nrf2/HO‐1 Pathway
Authors: Man Shuli , Bi Jingxian , Liu Furui , Xie Wenwen , Ma Long 
Published: February 2024

AbstractAs an important nutritional component, vitamin C (Vc) shows good antitumor activity in a variety of cancer, but there are few studies in pulmonary metastasis. In order to verify its anticancer and antimetastatic effect, the study sets up H22 pulmonary metastasis mouse model. The results show that intraperitoneal injection of Vc inhibits pulmonary metastasis through up‐regulating the expression of Nrf2, HO‐1, cleaved caspases 3 and 9, and causing DNA damage and apoptosis which is similar to the pro‐oxidant effect of Vc in p53 null cells (H1299 cells). Meanwhile, oral administration of Vc up‐regulates the expression of p53, directly activates Nrf2/HO‐1 pathway, increases expression of cleaved caspases 3 and 9, and ultimately inhibits pulmonary metastasis, which is the same as the antioxidant result of Vc in p53 wild‐type cells. In addition, Vc inhibits the proliferation and migration of lung cancer cells in a concentration‐dependent manner and has little cytotoxic effects on normal cells. Notably, the experiment further illustrates that besides intravenous Vc, oral Vc significantly inhibits the pulmonary metastasis in mice. All in all, these findings provide new clues for Vc‐treated pulmonary metastasis in clinical research.
Optimal starting dosing regimen of intravenous oxytocin for labor induction based on the population kinetic‐pharmacodynamic model of uterine contraction frequency
Authors: Yu Zhiheng , Chen Rong , Zhao Cheng , Zhang Renwei , Zhou Tianyan , Zhao Yangyu 
Published: February 2024

AbstractBackgroundIntravenous oxytocin is commonly used for labor induction. However, a consensus on the initial dosing regimen is lac with conflicting research findings and varying guidelines. This study aimed to develop a population kinetic‐pharmacodynamic (K‐PD) model for oxytocin‐induced uterine contractions considering real‐world data and relevant influencing factors to establish an optimal starting dosing regimen for intravenous oxytocin.MethodsThis retrospective study included pregnant women who underwent labor induction with intravenous oxytocin at Peking University Third Hospital in 2020. A population K‐PD model was developed to depict the time course of uterine contraction frequency (UCF), and covariate screening identified significant factors affecting the pharmacokinetics and pharmacodynamics of oxytocin. Model‐based simulations were used to optimize the current starting regimen based on specific guidelines.ResultsData from 77 pregnant women with 1095 UCF observations were described well by the K‐PD model. Parity, cervical dilation, and membrane integrity are significant factors influencing the effectiveness of oxytocin. Based on the model‐based simulations, the current regimens showed prolonged onset times and high infusion rates. This study proposed a revised approach, beginning with a rapid infusion followed by a reduced infusion rate, enabling most women to achieve the target UCF within approximately 30 min with the lowest possible infusion rate.ConclusionThe K‐PD model of oxytocin effectively described the changes in UCF during labor induction. Furthermore, it revealed that parity, cervical dilation, and membrane integrity are key factors that influence the effectiveness of oxytocin. The optimal starting dosing regimens obtained through model simulations provide valuable clinical references for oxytocin treatment.
Comparing the atmospheric and ocean characteristics associated with two distinctly intensified pre‐monsoon tropical cyclones over the Bay of Bengal
Authors: Paul Debashis , Panda Jagabandhu , Sarkar Ankan , Kumar Subodh , Zhu Yi‐Jie , Collins Jennifer 
Published: February 2024

AbstractTropical cyclone (TC) Amphan is analyzed in terms of the various factors that governed the intensification process associated with it and compared with Fani. Furthermore, the TC radial characteristics and ocean productivity are examined. Notably, both TCs formed in the Bay of Bengal during the pre‐monsoon seasons of 2020 and 2019, respectively. For this study, both ocean and atmospheric parameters from various sources including global analyses, satellite observations, and outputs from Model for Prediction Across Scales‐Atmosphere (MPAS‐A) and Advanced Research Weather Research and Forecasting (WRF‐ARW), are considered. The results indicate a gradual decrease in vertical wind shear during Fani. In the case of Amphan, the increase in mid‐tropospheric relative humidity values is found to be substantial. The sea surface cooling after the passage of Amphan was higher than in the case of Fani. The higher sea surface temperature in the Amphan case corresponds to the lower aerosol loading (partly because of lockdown measures) than that of Fani in the pre‐cyclone phase. And the decrease (increase) in aerosol loading coincides with an increase (decrease) in the direct radiative forcing at the ocean surface. The Madden–Julian Oscillation played a greater role in the cyclogenesis of Fani, but Kelvin waves offered a major support in the case of Amphan. The warmer sea surface, higher tropical cyclone heat potential, and conducive ocean and atmospheric setting together supported the further intensification of Amphan to the supercyclone stage. The difference in chlorophyll concentration showed a significant variation, with higher positive values seen in the case of Amphan implicating greater vertical mixing. The numerical modeling effort indicated superior performance of MPAS‐A compared to WRF‐ARW in simulating the radial parameters of the TCs.