bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengembangan Interaksi dan Perilaku Sosial Terhadap Pendidikan Anak Usia Dini di Abad 21
Authors: Mushab Al Umairi  
Published: March 2024

This research is motivated by the inability of early childhood in social interaction and good social behavior towards the environment, school, family and society in the 21st century (Modernization Era). To help reduce a child's disability in social interaction and good social behavior. therefore, it takes the efforts of help from adults. In providing this assistance, parents or teachers should understand the process of developing social interaction and social behavior towards early childhood. This study aims to determine the development of social interaction and social behavior towards early childhood education in the 21st century. The type of research used in this study is a type of field research (Field Research). Then to obtain the research data using the method of observation, interviews, and documentation. This research was analyzed using descriptive qualitative (in the form of opinions or written opinions from people and the actions observed). The conclusion of this study is that providing good social interaction and social behavior will have a positive impact on early childhood education in the 21st century.
Keywords: Social Inteaction; Social Behavior; Early Chilhood Education
Special Issue on Cutting Edge of Reinforcement Learning and its Hybrid Methods
Authors: Miyazaki Kazuteru , Takadama Keiki 
Published: March 2024

Since deep Q-networks and AlphaGO by Google DeepMind were proposed, not only a reinforcement learning integrated with deep learning but also its applications have attracted much attention on. ChatGPT, which learns by Proximal Policy Optimization as one of reinforcement learning mechanisms, is an excellent example.
With this background, we propose the special issue titled “Cutting Edge of Reinforcement Learning and its Hybrid Methods,” which is the same of the special issue in 2017, to cover the latest progress and trends in reinforcement learning and its hybrid methods (combined with machine learning, neural networks, and evolutionary computation).
We received 28 submissions, out of which 12 submissions were peer-reviewed and 16 submissions that were outside the scope of the special issue were excluded. After a thorough review process including comments and suggestions by reviewers, seven submissions were accepted. These included four theory and three application papers, indicating nearly equal contributions in theory and application aspects.
The content of the first three papers is related to inverse reinforcement learning, while the fourth one is not directly related to reinforcement learning but it would be related to reinforcement learning in the future. All papers address issues surrounding cutting-edge technology in reinforcement learning.
We would like to end by expressing that we hope and believe that this special issue can largely contribute to the development in the field of reinforcement learning while holding a wide international appeal.
A single-cell transcriptomic atlas of the lungs of patients with pulmonary tuberculosis
Authors: Sun Guoqiang , Li Kuan , Ping Jiale , Zhao Liyun , Cui Chao , Wu Junping , Xie Lixin , Ma Shuai , Fan Yan , Wang qiaoran , Zhang Weiqi , Qu Jing , Wang Si , Chen Huaiyong , Liu Guang-Hui 
Published: March 2024

Abstract
Patients with a history of mycobacterium tuberculosis infection commonly acquire irreversible and often progressive pulmonary defects. Here, we sought to understand, at a high resolution, the mechanisms underlying structural changes and functional impairments in lungs following tuberculosis (TB). To this end, we generated the first single-cell transcriptomic landscape of the human lung after TB infection, and deciphered disease-associated cell type-specific molecular profiles, including hyperinflammation, cell death, fibrosis, and cellular senescence, a thus far unappreciated molecular event of TB pathology. We identified prominent loss of pulmonary endothelial cells and augmented pulmonary vascular inflammation as hallmarks of disability in the post-TB lung. Mechanistically, we found that blunted FOXO3 and overactivated Thrombin-THBD signaling exacerbate vascular inflammation and cellular senescence in pulmonary endothelial cells. Overall, our work depicts a comprehensive single-cell transcriptomic atlas of pulmonary TB and provides potential therapeutic targets to relieve the pulmonary impairment after TB.
Step Network: A Neural Network that Takes Into Account Spatial Structure and Texture Features for Human Pose Transfer
Authors: Mo Han , Xu Yang , Zhang Caideng , Zhang Yongdan 
Published: March 2024

Abstract

Portrait synthesis guided by pose presents a challenging frontier in image generation. In our latest research, we have introduced an innovative network called the Step network, specifically designed to overcome the limitations identified in previous works. Our approach differs from traditional methods by honing in on the spatial structure of the pose, enabling a gradual migration of the pose while minimizing the loss of spatial structure information at each step. Taking inspiration from triplet loss, we have incorporated Style Discriminator to elevate texture generation. Moreover, in contrast to prior research, we have placed greater emphasis on refining the generation of facial areas. To achieve this, we employed a specialized loss function that combines triplet loss and L1 loss to optimize facial features, resulting in images that are more aligned with human perception. Additionally, we have also extended our method to include the ability to replace clothing on the body. To evaluate the quality of the images generated, we utilized evaluation metrics wihch are PSNR, SSIM, FID, and LPIPS. Through both qualitative and quantitative experiments comparing our approach with state-of-the-art models, we have demonstrated significant improvements across these metrics, confirming its superiority. Specifically, our method achieved a PSNR of 18.0376, SSIM of 0.7686, FID of 10.8102, and LPIPS of 0.1665. Our experimental results and open source code in the following url: https://github.com/FineURRight/Step-Network/tree/main.
Comparison of NRS-2002 and MST nutritional screening and correlation with quality of life items in lung cancer patients (REAL-TIME observation study)
Authors: Carnio Simona , Cantale Ornella , Capizzi Irene , Stura Ilaria , Nepote Alessandro , Samuelly Alessandro , Bernardi Giulia , Parravicini Maria Vittoria Pacchiana , Tinivella Marco , Tiozzo Elisa , Mariniello Annapaola , Parlagreco Elena , Tabbò Fabrizio , Lanzetta Cristina , Artusio Elisa , Capelletto Enrica , Bertaglia Valentina , Mogavero Andrea , Morelli Anna Maria , Passiglia Francesco , Bironzo Paolo , Mecca Caterina , Consito Lorena , Rio Benedetta Del , Napoli Valerio Maria , Arizio Francesca , Pasqualini Giorgia , Diberti Sara , Giurdanella Vincenza , Novello Silvia 
Published: March 2024

Abstract

Purpose
Approximately a 70% of lung cancer (LC) patients experience malnutrition. Therefore, a rapid and functional nutritional assessment is needed. Several nutritional screening instruments are available for clinical use. This study aimed to compare the Nutritional Risk Screening − 2002 (NRS-2002) and the Malnutrition Screening Tool (MST) to assess malnutrition in LC patients.
Methods
MST, NRS-2002, quality of life (QoL) assessment and Handgrip Test were performed in LC patients at baseline (T0), at day 30th (T1) and at day 90th (T2). The Edmonton Symptom Assessment System (ESAS) was used to assess patients’ QoL.
Results
The nutritional counselling intervention was offered to 198 LC patients. At T0, NRS-2002 and MST identified 141 and 127 patients at moderate/high risk of malnutrition, respectively. A concordance was observed between the two screening tests throughout the observation period with a correlation coefficient 0.7 (p < 0.001). LC patients with weight loss ≥ 5% at T0, age > 67 years and severe inappetence were more likely to report an NRS-2002 ≥ 3 while weight loss ≥ 5%, inappetence, malaise and depression were significantly associated with an MST ≥ 3.
Conclusion
These results suggest that both NRS-2002 and MST are useful tools to detect malnutrition in LC patients, with several QoL items associated with malnutrition status.
Vacant niches in a species-poor system: resource partitioning based on diet quality for a Mexican clam in the Baltic Sea
Authors: Karlson Agnes ML , Kautsky Nils , Granberg Matilda , Garbaras Andrius , Lim Hwanmi , Liénart Camilla 
Published: March 2024

Abstract
Invasive species are often generalist species that can take advantage of formerly unexploited resources. The existence of such vacant niches is more likely in species-poor systems like the Baltic Sea. The suspension-feeding wedge clam, Rangia cuneata, native to estuarine environments in the Gulf of Mexico, was sighted for the first time in the southeastern Baltic in 2010 and a few years later in the north along the Swedish coast. To explore possible competition for food resources between R. cuneata and the three native clams inhabiting Baltic shallow soft bottoms, stable isotope and fatty acid analyses were conducted. There was no overlap between R. cuneata and any of the native species in neither stable isotope nor fatty acid niches. This suggests efficient partitioning of resources; multivariate analyses indicate that separation was driven mainly by δ13C and by certain fatty acids reflecting different phytoplankton groups. R. cuneata reflected seasonal variation in phytoplankton more than other clams and contained more of fatty acid biomarkers for cyanobacteria reflecting higher trophic plasticity. In conclusion, the addition of R. cuneata to the Baltic shallow soft bottoms suggest the existence of a vacant niche, however long-term effects on other species and on nutrients cycling require further studies.
Is unilateral biportal endoscopic discectomy superior to percutaneous interlaminar endoscopic discectomy in the treatment of L5/S1 disc herniation? A retrospective study
Authors: YIN Jianjian , MA Tao , GAO Gongming , CHEN Qi , NONG Luming 
Published: March 2024

Abstract

Purpose
To compare the clinical outcomes of unilateral biportal endoscopic discectomy (UBED) and percutaneous interlaminar endoscopic discectomy (PIED) for treating L5/S1 disc herniation.
Methods
Patients with L5/S1 disc herniation treated with UBED (n = 46) and PIED (n = 50) in our hospital during the same period were retrospectively reviewed. Total blood loss (TBL), operation time, hospital stay, complications, total hospitalization costs, clinical efficacy and modified MacNab criteria were collected and evaluated. Percentage of facet joint preservation measured on axial CT scans obtained pre-operation and post-operation.
Results
The mean follow-up period was 14.07 ± 3.50 months in UBED group, and 14.52 ± 5.37 months in PIED group. The total blood loss and hospitalization cost was more in the UBED Group. The operative time and hospital stay time in the UBED Group was similar with that in PIED Group. The postoperative VAS back, leg scores and ODI score were significantly improved compared with the preoperative scores in both two groups. There was no significant difference in VAS back and leg scores between two groups at 1-day post-operation and final follow-up period. All patients of two groups had similar ODI scores at final follow-up period. The percentage of facet joint preservation is 96.56 ± 9.11% in UBED group, which is significantly less than in PIED group with 99.22 ± 1.52%. One patient in both groups showed postoperative hematoma. A dural tear occurred in UBED group and a never root injury occurred in PIED group. There was no significant difference in patient satisfaction rates between two groups.
Conclusion
UBED indicates similar clinical effect compared with PIED for treating L5/S1 disc herniation, and there was no significant increase in surgical time or hospital stay. However, more facet joint damage, total blood loss and hospitalization cost may be the disadvantages of UBED technique and need to be taken seriously.
Effect of Transcutaneous Electrical Stimulation (TENS) on labor pain and the duration of first stage of labor.
Authors: Joseph Smita Elizabeth , Thomas Annamma , Mhaskar Rita , Michael John 
Published: March 2024

Abstract
Purpose: Labour pain is caused by contraction of the uterine muscles and the pressure of the baby’s presenting part on the cervix. The effective management of labour pain plays a decisive role in the labour outcome indicating the need for a non-pharmacological therapy to manage labour pain.
Methods: A randomized controlled trial was conducted on 300 pregnant women at low antenatal risk who anticipated full term vaginal delivery in a tertiary care hospital in Urban South India. During the active phase of first stage of labour, the women in the experimental group received TENs which was increased in intensity with the increase in pain and the women in the control group received TENS at baseline intensity. Both groups of women received the routine obstetric care. The primary outcome measure was intensity of labour pain assessed using the Visual Analog Scale at 3-4 cms of cervical dilatation and at full cervical dilatation. An independent sample t-test compared the mean VAS scores and labour duration between groups. A Chi-square test was used to compare categorical variables between the groups.
Results: The experimental group (n=150) had statistically significantly lower mean VAS scores at full cervical dilatation than the control group (n=150) (p < 0.001) and a statistically significant shorter duration of the active labour phase than the control group (p < 0.001).
Conclusion: The results of this study indicate that TENS can be used as a non-pharmacological therapy to reduce pain perception and to shorten the active phase of first stage of labour.
Enhancing Quality of Life and Emotional Well- Being: A Prospective Analysis of Patients Undergoing Diathermy Ablation for Cervical Intraepithelial Neoplasia
Authors: Kotani Kiriko , Banno Sumi , Mitani Takeji , Nishizawa Haruki , Iwata Aya , Fujii Takuma 
Published: March 2024

Abstract
This study aimed to analyze the changes in quality of life (QOL) and emotional well-being of patients undergoing diathermy ablation for cervical intraepithelial neoplasia 2/3 (CIN). A total of 40 patients were recruited for a prospective clinical trial, and the European Organization of Research and Treatment for Cancer (EORTC)-QLQ-C30 and EORTC-QLQ-CX24 questionnaires were used to assess QOL before surgery and at 3 and 6 months postoperatively. Friedman and Wilcoxon tests were employed for statistical analysis. The results showed significant improvements in emotional functioning, body image, symptom experience, and physical functioning after surgery. Vaginal discharge and abnormal bleeding decreased over time, indicating improved symptom control. Sexual activity was temporarily affected but eventually returned to preoperative levels at six months after surgery. This study highlights the positive impact of diathermy ablation on patients' psychological well-being and QOL, and emphasizes the importance of patient-centered care in the treatment of CIN. These survey questionnaires will make it possible to globally compare QOL assessments between patients undergoing various treatments, such as trachelectomy, for cervical cancer and those with precancerous lesions in the future.
Identification and Characterization of Abiotic Stress Induced novel UDP-Glucosyltransferase (UGT72L11) Gene from Glycyrrhiza glabra L.
Authors: Hussain Shahnawaz , Verma Bhawna , Manzoor Malik Muzafar , Goyal Pooja , Devi Ritu , Gupta Ajai Prakash , Dhar Manoj kumar , chowdhary Fariha , Gupta Suphla 
Published: March 2024

Abstract
The present study reports a unique broad spectrum UDP-glycosyltransferase from Glycyrrhiza glabra involved in multiple stress responses and abscisic acid mediated glycosylation. The identified UGT72L11gene was cytoplasmic with ORF of 1425 bp encoding a 52.2 kDa protein of 474 amino acids. Phylogenetic analysis revealed maximum homology (73.3%) with epicatechin 3-glucosyltransferase (ACC38470) from Medicago truncatula exhibiting sequence uniqueness. The gene was differentially expressed in shoot tissues and significantly upregulated in abscisic acid treatment (122.3 folds) and under cold stress (36 folds) in planta. In-silico Structure-Activity-Relationship revealed GLU279, ARG386, PRO380 and TRP379 residues being involved in receptor-ligand interactions. The UGT72L11 protein was optimal between 10ºC to 30ºC preferring quercetin-UDPGlc (Km 0.23) over kaempferol-UDPGlc (Km 0.47). The purified recombinant protein showed multi-substrate O-glycosylation towards various classes of aglycones, abscisic acid, and also displayed C-glycosylation with colchicine as a foundation for the future medicinal applications.
Cytological characterization and molecular marker development for wheat-Thinopyrum ponticum translocations carrying leaf rust and stem rust resistance genes Lr24 and Sr24
Authors: Li Jianbo , Guan Haixia , Wang Yuqi , Dong Chongmei , Trethowan Richard , McIntosh Robert , Zhang Peng 
Published: March 2024

Abstract
Previous studies showed that Australian wheat cultivars Janz and Sunco carry leaf rust and stem rust resistance genes Lr24 and Sr24 derived from Thinopyrum ponticum chromosome arm 3AgL. However, the size of the alien segments carrying Lr24 and Sr24 in the lines were not established. In this study, we used non-denaturing fluorescence in situ hybridization (ND-FISH), genomic in situ hybridization (GISH), and PCR-based landmark unique gene (PLUG) markers to visualize the alien segments in Janz and Sunco, and further compared them with the segments in cultivars Agent and Amigo. The fraction length (FL) of the alien translocation in Agent was 0.70-1.00, whereas those in Janz, Sunco, and Amigo were smaller, at FL 0.85-1.00. It was deduced that the alien gene RAg encoding for red grain color and rust resistance genes Lr24 and Sr24 on chromosome arm 3AgL were in bins of FL 0.70–0.85 and 0.85-1.00, respectively. We retrieved and extracted nucleotide-binding site-leucine-rich repeat (NBS-LRR) receptor genes corresponding to the region of Lr24 and Sr24 on chromosomes 3E, and 3J, 3Js and 3St from the reference genome sequences of Th. elongatum and Th. intermedium, respectively. A set of molecular markers developed for Lr24 and Sr24 from those extracted NBS-LRR genes will provide valuable information for fine mapping and cloning of these genes.
Short Term Outcomes and Predictors of Mortality of Preterms Who Had Continuous Positive Airway Pressure Initiated at Delivery at in Urban Sub Saharan African Setting: A Retrospective Cohort Study
Authors: Patrick Baingana , Erem Geoffrey , Nakibuuka Victoria , Mworozi Edison 
Published: March 2024

Abstract

Background Continuous Positive Airway Pressure (CPAP) is a low-cost treatment modality for respiratory distress syndrome that has been shown to improve survival of preterm infants. However, its application at delivery is not routinely practiced in Uganda and Africa despite evidence from high income countries. Short term outcomes and predictors of mortality of preterm infants initiated on CPAP at Delivery at the St Francis hospital, Nsambya was reviewed in this study.Methods A retrospective cohort study was conducted at St Francis Hospital, Nsambya Neonatal Unit. Maternal and Neonatal records of Preterm infants that had CPAP initiated at delivery from January 2018 to December 2021 were reviewed. The proportion of preterm infants that survived to discharge were determined, those that required mechanical ventilation and surfactant replacement therapy. The predictors of mortality were determined using Cox proportionate hazard model. Kaplan Meier survival curve was used to determine survival probability.Results A total of 198 patient’s records were reviewed, the mean age of mother was 29 years and139 (70.2%) were delivered by cesarean section. 109 (55.1%) of the preterm infants were female, 146 (73.7%) survived to discharge.31 (15.7%) required mechanical ventilation and 38 (19.2%) received surfactant replacement therapy. The mean survival time was 42 days and predictors of mortality were gestation age less than 31 weeks, apnea of prematurity, pulmonary hemorrhage and APGAR score of less than 6 at 5 minutes.Conclusions The survival of preterm infants with respiratory distress was high when CPAP was initiated at delivery and small proportion required surfactant and mechanical ventilation. However, preterm infants delivered less than 31 weeks of gestation, having apnea of prematurity, pulmonary hemorrhage and an APGAR score less than 6 at 5 minutes had an increased the risk of mortality. Thus mortality of preterm infants that receive CPAP early can be reduced by intervening on the above predictors
Acetylation-dependent control of SIAH2 links JAK2V617F to mitochondrial respiration and ROS-associated apoptosis
Authors: Krämer Oliver , Mustafa Al-Hassan , Petrosino Giuseppe , Fischer Marten , Ricciardi Luisa , Gül Désirée , Christmann Markus , Morrison Helen , Wirth Matthias 
Published: March 2024

Abstract
Epigenetic modulators of the histone deacetylase (HDAC) family control key biological processes. We used leukemic cells with the constitutively active kinase oncoprotein JAK2V617F as models to define the incompletely understood control of cytoplasmic signaling and cell organelles by nuclear HDACs. We reveal that HDAC1 and HDAC2 control JAK2V617F through the ubiquitin-ligase seven-in-absentia-homologue-2 (SIAH2). Inhibition of HDAC1/HDAC2 stabilizes SIAH2 and accelerates proteasomal degradation of JAK2V617F which has a surface-exposed SIAH degron motif in its catalytic domain. This acetylation-dependent loss of JAK2V617F and its downstream signaling to the inducible transcription factor STAT1 disrupts expression of the mitochondrial chaperone SMIM20. Consequently, inactivation of HDAC1 and HDAC2 disengages the electron transport chain of oxidative phosphorylation and causes ROS-associated, pro-apoptotic DNA damage. This study links the nuclear located HDAC1/HDAC2 to JAK-STAT-dependent mitochondrial functions, redox homeostasis, and genomic stability.