bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of Simplified Capacitance Resistance Model Approach (CRM) to Optimize Inverted Nine Spot Injection Pattern
Authors: Wan Khairul Anuar W. M. , Romle A. N. , Kamis A. B. , Motaei E. , Kamat D. 
Published: March 2024

Abstract
As the oil and gas industry continues to evolve, advanced analytical tools have become a critical component in improving field withdrawal and injection performance. This paper showcases the effectiveness of the Simplified Capacitance Resistance Model as an analytical tool in optimizing an inverted nine-spot injection pattern in a large carbonate oil field with over 100 producers and water injectors. Additionally, the paper explores how these methods can improve the overall efficiency of pattern waterflooding in the field.
The overall approach integrates the simplified CRM to balance withdrawal and injection patterns. Initially, basic surveillance data is used to optimize production and withdrawal surveillance. To incorporate connectivity understanding between injectors and producers, Simplified CRM output is added as additional parameters in the inverted nine-spot pattern to optimize production strategy.
The integrated approach presented in this paper has resulted in optimized injection and withdrawal across injection patterns, assisting to regulate field production for long-term sustainability. For each injector surrounded with a minimum of 8 producers, this approach governs the withdrawal and drawdown from each producer to ensure consistent oil sweep within the patterns. In addition, it also acts as an optimization tool to cater for any production balancing required by the production facilities, improving response time to mitigate production setback and realizing production requirement. The approach effectively incorporates a large amount of surveillance data into a systematic work process, providing clear output and optimization production strategy.
This paper presents an alternative approach to utilize the simplified CRM as an analytical tool for pattern balancing in a large carbonate oil field. The use of simplified CRM to optimize production and withdrawal surveillance adds to the state of knowledge in the petroleum industry. It will benefit readers facing similar scenarios and field configurations.
“And who would question God?”: Patient engagement and healthcare decision-making of South-Asian older adults in the Canadian healthcare system
Authors: Chowdhury Diya , Tong Catherine , Neiterman Elena , Lopez Kimberly , Stolee Paul 
Published: March 2024

Abstract
With the increase in ethnocultural diversity in the Canadian demographic landscape, it is imperative for healthcare providers and policy makers to understand the needs and preferences of racialized immigrant older adults. Previous research has shown that to increase patient satisfaction with care and lower treatment costs it is important to effectively involve patients in their care. However, we currently lack the understanding of how racialized immigrant older adults want to engage as patients, the factors that influence their involvement in their own care, and who they want involved in the decisions surrounding their care. To address this gap in the literature specifically for the South Asian community, one of Canada’s largest and fastest growing populations, our study aimed to understand South Asian older adults’ experiences with and approaches to patient engagement and shared decision-making. We conducted in-depth individual and dyadic interviews (n=28) in six languages, utilizing a multilingual cross-cultural qualitative approach. Our findings highlight the nuances of language and how miscommunication can arise even when patients and providers are conversing in the same language. Our study also found that patient engagement and shared decision-making, including the desire for family involvement, is heavily influenced by both culture and gender. Additionally, perceptions of patients regarding the status of physicians can have a notable influence on patient engagement, leading to an increased tendency for patients to agree with the physicians’ approach to care. These findings suggest that effective engagement between providers and patients require a tailored approach that extends beyond white-centric approaches to decision-making and communication.
Evaluating Nirmatrelvir-Ritonavir (Paxlovid®) in Outpatient COVID-19 Treatment: Safety, Tolerability, and Adherence Insights from Primary Healthcare Clinics
Authors: Zaharuddin Zahirah , Hus Nur Sabiha Md , Karuppannan Mahmathi 
Published: March 2024

Abstract

Objective: This study aims to fill this gap by evaluating the safety, tolerability, and adherence of patients prescribed Paxlovid® in outpatient settings, focusing on its use in managing category 2 COVID-19 patients across three primary healthcare clinics in Selangor, Malaysia.
Design: Retrospective cross-sectional study
Setting: Data were collected from the Paxlovid® pharmacy registry and medical records at Klinik Kesihatan Seksyen 7, Klinik Kesihatan Seksyen 19, and Klinik Kesihatan Kelana Jaya between April 1, 2022, and November 30, 2022.
Participants: This study analysed data from 415 category 2 COVID-19 patients aged ≥18 years old.
Primary and secondary outcomes: Parameters assessed included patient demographics, dosing, current medication, changes in drug regimen, adherence, and ADR. Pharmacists follow-ups were conducted on days 3 and 5 post-medication initiation.
Results: The majority (79.5%) of the cohort experienced ADR, predominantly dysgeusia, diarrhoea, body ache, vomiting, and nausea. Despite these, the ADR were generally well-tolerated, with no severe impacts reported. High adherence was observed, with 96.9% of patients completing the 5-day regimen. The primary reasons for non-adherence included adverse effect intolerability, dosing ambiguity, forgetfulness, concerns about ADR, and perceived health improvement. Notable medications interacting with Paxlovid® were simvastatin, amlodipine, and atorvastatin, and 21.7% of 23 concurrent medications were found not complying to the recommended interventions by the University of Liverpool COVID-19 Drug Interaction database.
Conclusion: Nirmatrelvir-ritonavir (Paxlovid®) demonstrates a high level of safety and tolerability in outpatient COVID-19 patients, with optimal adherence observed. This study underscores the vital role of healthcare professionals in managing Paxlovid® within primary healthcare and highlights the need for broader research and direct patient involvement to enhance treatment strategies against COVID-19.
Investigations on Additive Manufactured Gyroid Lattice Structures Using AlSi10Mg
Authors: Managuli sangamesh C , Munesha Chiranth , Naresh Darshan , Yuvaraju Dinesh , Basavaraju Akhilesh Kenchanakuppe 
Published: March 2024

Abstract
Lattice structures are three-dimensional frameworks characterized by an interconnected network of struts or beams, often resembling geometric shapes such as gyroids. This study investigates the compressive behavior of functionally graded gyroid lattice structures fabricated from AlSi10Mg using selective laser sintering. Through systematic variation of design parameters such as relative density, cell size, uniform wall thickness, and gradient of wall thickness, the research examines how these factors affect mechanical stability and collapse mechanisms under load. Compression testing provides insights into strength, deformation, and failure modes of the structures, offering valuable contributions to the understanding of their compressive strength. The findings have significant implications for applications requiring lightweight yet robust structures, particularly in aerospace, automotive, and other engineering disciplines, thereby advancing the field of metal additive manufacturing and its potential in advanced structural designs.
Unlocking the Prospective of Neglected and Underutilized Wild Plants for Human Food, Nutrition and Ethno-Medicine
Authors: Abuka Mihretu , Feyissa Getachew Sime 
Published: March 2024

Abstract

Wild edible plant species (WEPs) are vital sources of additional food and ethnomedicine in many regions of the world. Despite the fact that they can offer a range of provisioning services, they are neglected, underutilized, and poorly researched. This study therefore investigated WEPs and their provisioning ecosystem services as supplementary food, nutrition, and traditional medicine. Questionnaire household surveys, key informant interviews, and a series of field observations were used for data collection. Additionally, preference ranking was used to rank the WEPs based on the preference of the local communities for their provision of services. A direct matrix ranking was carried out to measure their provisional service diversity. There were 20 WEPs species, which were most widely used as food, nutrition, and ethnomedicine supplements. The major edible plant parts were fruits (75%), which were mostly collected by children (65%). The majority of the communities (93.95%) used them as seasonal and supplemental food, particularly in periods of food shortages such as spring, the dry season. They were particularly essential supplementary sources of food, nutrition, and ethno-medicine for food-insecure and economically marginal families. It is therefore necessary to develop national policies that support and encourage WEPs as dietary, nutritional, and ethno-medical supplements.
High myoglobin level as an independent risk factor for death in patients with critical COVID-19 infection：A retrospective case-control study
Authors: Sun Xiaoxiao , Zhang Hui , Zhang Meixian , Fei Miaomiao , Xiong Lize , Li Cheng 
Published: March 2024

Abstract

Aim
This study aimed to discover risk factors for death in patients with critical COVID-19 infection in order to identify patients with a higher risk of death at an early stage.
Methods
We retrospectively analyzed the clinical data of patients with critical COVID-19 infection from April 2022 to June 2022. Data were collected from the electronic medical records. Propensity matching scores were used to reduce the effect of confounding factors, such as patient baseline variables. Independent risk factors affecting patient prognosis were assessed using univariate logistic regression and multivariate logistic regression analysis. Restricted cubic spline curves were used to assess the relationship between independent and dependent variables.
Results
The data of 137 patients with critical COVID-19 infection were collected. Of the 137 patients, 84 survived and 53 died. Among laboratory indicators, patients who died had higher proportions of abnormalities in RDW SD, procalcitonin, aspartate aminotransferase (AST), creatinine, potassium, cardiac troponin I, and myoglobin. Univariate and multivariate logistic regression analyses suggested that abnormal AST (OR = 3.26, P = 0.044), creatinine (OR = 4.49, P = 0.037), and myoglobin (OR = 9.88, P = 0.025) were independent risk factors for death. After correction for AST and creatinine, a linear relationship between myoglobin and risk of death in patients was found using restricted cubic splines.
Conclusion
High myoglobin level is an independent risk factor for death and is therefore a prognostic marker in patients with severe COVID-19 infection.
Development of atmospheric pressure air dielectric barrier glow discharge in large gaps through modulation of pulsed power supply upon AC
Authors: Haghani Saeedeh Faghih , Seyfi Pourya , Ghomi Hamid 
Published: March 2024

Abstract
The development of dielectric barrier discharge (DBD) in glow mode in large gaps in air at atmospheric pressure, due to providing diffuse, uniform, safe, and economic treatments for a wide range of substrates and for many applications, could be a beneficial way to enhance cold plasma applications in various industries. Here, we generated a glow DBD that has a volume-surface coupling geometrical structure in a 1mm gap distance by a pulsed power supply and expanded the gap distance up to 2 cm by modulating the pulsed power supply on an AC one. The resulting glow discharges were studied by voltage-current waveform and atomic emission spectroscopy.
ncRNAs-mediated high expression of ITGB1 correlates with poor prognosis and tumor immune infiltration in gastric cancer
Authors: Sun Jingxian , Su Wei , Wang Zhiqiang , Wang Xiao , Ma Xiaoguang , Zhao Rui 
Published: March 2024

Abstract

Background: Gastric cancer (GC) is a highly heterogeneous and complex disease. Recent evidence has shown that members of the Integrin β superfamily (ITGBs) play crucial roles in the initiation and progression of various types of human cancer. However, the specific role and mechanism of ITGB1, one of the representative factors within the integrin family, in GC have not been fully elucidated.
Methods: The study systematically analysed the expression and prognostic significance of ITGBs in pan-cancer using data from The Cancer Genome Atlas (TCGA) and The Genotype-Tissue Expression (GTEx). Multivariate regression analysis was used to identify the key factors that influence the prognosis of GC. Noncoding RNAs (ncRNAs) that contribute to ITGB1 expression were subsequently identified through a combination of in silico analyses, including expression, correlation, and survival analysis. The relationship between ITGB1 and its lncRNA MIR99AHG expression with tumor immune cell infiltration, biomarkers of immune cells, and immune checkpoint expression in GC was then elucidated.
Results: Compared to the adjacent normal tissue, the results show a significant increase in ITGB1-2 and ITGB4-8 mRNA levels in GC. Cox regression and Kaplan-Meier survival analyses indicate that elevated expression of ITGB1 is associated with a poor prognosis and can serve as an independent prognostic factor in GC patients. The MIR99AHG/hsa-mir-17-5p axis has been identified as the most promising upstream ncRNA-related pathway involved in regulating ITGB1 expression in GC through comprehensive expression analysis, correlation analysis, and survival analysis. Additionally, the expressions of both ITGB1 and MIR99AHG have been validated through immunohistochemical analysis using our collection of GC tissues. Finally, our study shows a positive correlation between the levels of infiltrating CD4+ T cells, macrophages, and dendritic cells, and the expression of ITGB1. High levels of macrophages are particularly indicative of a better prognosis in GC.
Conclusion: Our findings suggest that ncRNAs-mediated ITGB1 expression is associated with poor prognosis and tumor immune infiltration in GC. However, it is necessary to conduct further validation through extensive basic experiments and large-scale clinical trials in the future.
Effect of additional energy supplement of roasted soybean, soybean oil, bypass fat and extra concentrate on biochemical and metabolic profile in lactating Murrah buffaloes
Authors: Yadav Danveer Singh , Lakhani Gandhi Prasad , Choudhary Rashmi , Roy Biswajit , Mishra Aditya , Jamra Mohabbat Singh , Rawat Nawal Singh 
Published: March 2024

Abstract
The study was conducted to see the effects of additional energy supplementation on the biochemical and metabolic profile in lactating Murrah buffaloes. The study was conducted at Livestock Farm, Adhartal, College of Veterinary Science and Animal Husbandary, N.D.V.S.U., Jabalpur (M.P.) for a period of one year (July, 2018 to June, 2019). A total of 30 lactating Murrah buffaloes were selected and randomly distributed to six groups. The study was carried up to 90 days post-partum. Animals of the group-1 (T1) received only basal diet as per ICAR (2013) requirements. Whereas group-2 (T2), 3 (T3), 4 (T4) and 5 (T5) were supplemented with 5% additional concentrate (T2) or 100 ml soybean oil (T3) or 100 g bypass fat (T4) or 100 g roasted soybean (T5) per animal/day. Other than feed, all the animals were maintained under same managemental conditions. The experimental animals were fed as per their body weight and production following ICAR (2013) requirements. They were fed twice daily according to schedule at 5:30 am and 3:00 pm and water was kept available to animals round the clock. The data recorded during the study were analysed statistically using descriptive statistics, one way ANOVA. Non-significant differences were observed among groups for blood glucose and BUN level. The higher NEFA concentration (mmol/l) was observed in groupT1 (0.47). The blood sodium concentration (mEq /L) had significantly decreased among the groups from initial day to 90th day of lactation and was higher in T3 (143.54) as compared to T1 (140.94) group. Significant findings were observed among groups about blood potassium, chloride and calcium concentration while phosphorus concentration was non-significant. Conversely, the blood alkaline phosphatase concentration had decreased significantly due to additional energy supplementation in different groups. Hence, based on the findings of study, it has been concluded that supplementation of 100g soybean oil was most economical followed by 100g of roasted soybean. It was followed by 5% additional concentration feeding and 100g bypass fat.
Phosphorus-Modified Metal-Organic Frameworks for the Effective Removal of Thorium from Aqueous Solutions
Authors: Zhuang Yinghao , Sun Shuai , Jia Kai , Wang Shao , Shi Lei , Yang Xiangshan 
Published: March 2024

Abstract

Thorium (Th), as a promising nuclear fuel, can cause serious radioactive contamination even in a small amount in nuclear wastewater. Therefore, it is urgent to develop effective adsorbents for the removal of thorium. Herein, phytic acid modification of carboxylated zirconium based on metal-organic framework (UIO-66-COOH-PA) was obtained by rapid high-temperature carbonization, which exhibited excellent performance in removing Th (IV) in acidic solutions. The maximum adsorption capacity of UIO-COOH-PA-2 (with phytic acid mass ratio of 40%) reached 315.5 mg/g at pH of 4, which was more than twice that of the unmodified Zr-based MOF material (151.2 mg/g). The thorium adsorption process reached dynamic equilibrium quickly at different temperatures. Freundlich model fitted the thorium adsorption kinetics of UIO-COOH-PA better and its adsorption dynamics followed the pseudo-second-order kinetic model. The excellent adsorption performance of UIO-COOH-PA-2 at low pH values indicated that the adsorption materials containing phosphorus were suitable for the removal of thorium especially in acidic systems. It also exhibited excellent selectivity (up to 90.2%) for Th (IV) adsorption in the presence of many coexisting rare-earth ions. These results will provide a new strategy for the design of adsorbents for efficient removal of thorium from radioactive acidic wastewater environments.
A Unified Approach for Time and Frequency Domain Finite Element Model Updating
Authors: Li Dan , Zhou Jiajun , He Xinhao 
Published: March 2024

Abstract

Reliable finite element (FE) models play a vital role in accurately predicting structural behaviors under various loading conditions in structural engineering applications. This paper presents a unified approach for solving both time and frequency domain FE model updating problems. In this approach, both types of problems are formulated as stochastic dynamic systems with embedded parameter-to-data maps, enabling the estimation of unknown model parameters. The unscented Kalman method is employed as an effective tool to solve these dynamic systems and update the parameters. Additionally, this study addresses specific settings within FE model updating, including constraints implementation, covariance inflation, and sparsity regularization. Constraints on estimated parameters are effectively incorporated, ensuring adherence to predefined bounds. Covariance inflation techniques are applied to account for uncertainties not accurately captured by assumed covariance matrices. Moreover, sparsity regularization techniques are introduced to promote sparsity in estimated parameters, facilitating more accurate and interpretable results for special applications such as damage identification. The proposed unified approach is numerically verified through extensive simulations. The results demonstrate the effectiveness and reliability of the approach in accurately estimating the unknown parameters of FE models for structural engineering applications.
Lenvatinib Improves the Relative Abundance of Probiotics in Intestinal Flora of Patients with Primary Liver Cancer
Authors: Chai Xin , Tang Yue , Li Ximeng , Zou Shansi , Guan Xutao , Zang Wenqiao , Wang Tao 
Published: March 2024

Abstract

Background
Lenvatinibis commonly used systemic therapeutic drugs for patients with advanced Primary Liver Cancer (PLC). Recent studies have found that gut microbiota can regulate the efficacy of anti-tumor drugs. However, the relationship between antiangiogenic drugs and intestinal flora is not clear, and there is no relevant clinical research.
Methods
We investigated Lenvatinib's impact on PLC patients' intestinal flora. Fecal samples from pre- and post-treatment PLC patients were analyzed via 16S rRNA Illumina sequencing.
Results
Notably, Bifidobacterium, Coprococcus, and other genera varied between groups at the genus level. The relative abundance of probiotics (Bifidobacterium, Coprococcus) significantly rose post-treatment. The Lefse analysis revealed significant differences. Following Lenvatinib treatment, PLC patients exhibited 12 biomarkers, including Clostridia, Bifidobacterium, Bifidobacteriaceae, Bifidobacteriales, Faecalibacterium, Butyricicoccus, Butyricicoccaceae, Ruminococcaceae-uncultured, Ruminococcaceae-Incertae_Sedis, Lachnospiraceae_NK4A136_group, Ruminococcaceae, and Lachnospiraceae_UCG_010.
Conclusions
Lenvatinib increased the relative abundance of probiotics in PLC patients' intestinal flora, suggesting therapeutic implications.
Multi-scale analysis method for crack damage in 8Cr4Mo4V alloys
Authors: Cao Hongrui , Ma Tianyu , Gong Gu , Shi Jianghai , Wei Xunkai , Zhang Lijun 
Published: March 2024

Abstract
8Cr4Mo4V, as an ideal choice for aeroengines bearing materials, involves multi-scale damage mechanisms of the fatigue crack failures. Herein, we propose a multi-scale analysis method to analyze the crack initiation and propagation damage mechanisms of 8Cr4Mo4V alloy. We find that different crystal orientations produce distinctly different damage mechanisms. The second phase doping also has different strengthening effects on the matrix following bypass and cut-through mechanisms. Meanwhile, the study of the polycrystalline model verified the micro-scale inverse Hall-Petch relation, where material strength decreases with grain refinement. Phase transitions caused by dislocations lead to stress concentration at specific grain boundaries, becoming the main inducer for the nucleation of initial voids. To address micro-to-macroscale-crossing issues, we constructed a large-scale mesoscopic molecular dynamics simulation and proposed an analytical formula to predict the relationship between average grain size and yield stress. Finally, we combine macroscopic experiments, crystallographic analyses, and atomic-scale characterization, verifying the combined action of dislocations and stacking faults leads to the failure of the material.