bluuebunny/crossref_metadata_2025_split huggingface dataset:
Plate augmentation and hybrid bone grafting are effective treatments for atrophic nonunion of the femur with the original intramedullary nail retained in situ
Authors: Qiang Huang , Congming Zhang , Teng Ma , Kun Zhang , Chaofeng Wang 
Published: March 2024

AbstractThe purpose of this study is to evaluate the efficacy of plate augmentation and hybrid bone grafting for treating atrophic nonunion of the femur with original intramedullary nail retained in situ.In this study, 36 patients with atrophic nonunion of the femur who underwent surgery using the technique of plate augmentation and a hybrid bone grafting while retaining the original intramedullary nail in situ in Xi’an Honghui Hospital from January 2019 to December 2021 were enrolled. 28 patients who met the inclusion and exclusion criteria were ultimately included in the study. These 28 patients, consisting of 20 males and 8 females with a mean age of 38 years, were evaluated based on factors such as operation time, intraoperative blood loss, the average hospitalization days. Additionally, the results and function of these patients were evaluated by union time, Wu’s scores of limb function and incidence of serious complications.All 28 patients achieved bone union at the 12 month follow-up, with an average follow-up time of 14.6 ± 4.2 months.The average operation time was 68.3 ± 11.2 min, and the average intraoperative blood loss was 140 ± 22.6 ml. Patients were hospitalized for an average of 5.8 ± 1.1 days. Full clinical and radiological bone union was achieved on average at 5.1 ± 1.9 months. The mean value of Wu's scores at the 12 month follow-up was significantly higher than before the operation. Limb function was excellent in 27 patients and good in one patient at the 12 month follow-up. However, five patients experienced the lower limb vein thrombosis, including one deep vein thrombosis and four lower limb intermuscular vein thromboses. One patient had a superficial infections of the surgical incision site, while three patients reported pain and numbness where their iliac bone graft was extracted at the 12 month follow-up. The technique of plate augmentation and hybrid bone grafting, combined with retaining the original intramedullary nail in situ has been shown to be a safe, effective, simply and standardizable practice for treating atrophic femoral nonunion with an intact original IMN fixation.
ATP releasing channels and the ameliorative effects of high intensity interval training on diabetic heart: a multifaceted analysis
Authors: Joukar Siyavash , Rajizadeh Mohammad Amin , Bejeshk Mohammad Abbas , Alavi Samaneh Sadat , Bagheri Fatemeh , Rami Mohammad , Khoramipour Kayvan 
Published: March 2024

AbstractType 2 diabetes (T2D) can cause severe cardiac complications at functional, histologic and molecular levels. These pathological complications could be mediated by ATP-releasing channels such as Panx1 and ATP receptors, in particular P2X7. The aim of our study was to investigate the effect of high-intensity interval training (HIIT) on T2D-induced cardiac complications at the functional, histopathological and molecular levels, with a particular focus on ATP-releasing channels. 48 male Wistar rats at the age of 8 weeks were randomly allocated into four groups: control (Con), Diabetes (T2D), Training (TR), and Diabetes + Training (T2D + TR). T2D was induced by a high-fat diet plus a low dose (35 mg/kg) of STZ administration. Rats in the TR and T2D + TR groups underwent an 8-weeks training program involving intervals ranging from 80 to 100% of their maximum running speed (Vmax), with 4–10 intervals per session. Protein expression of Interleukin 1β (IL1β), Interleukin 10 (IL-10), Pannexin 1 (Panx1), P2X7R (purinergic P2X receptor 7), NLRP1 (NLR Family Pyrin Domain Containing 1), BAX, and Bcl2 were measured in the heart tissue. Additionally, we assessed heart function, histopathological changes, as well as insulin resistance using the homeostasis model assessment of insulin resistance (HOMA-IR). In contrast to the T2D group, HIIT led to increased protein expression of Bcl2 and IL-10 in the heart. It also resulted in improvements in systolic and diastolic blood pressures, heart rate, ± dp/dt (maximum and minimum changes in left ventricular pressure), while reducing protein expression of IL-1β, Panx1, P2X7R, NLRP1, and BAX levels in the heart. Furthermore, left ventricular diastolic pressure (LVDP) was reduced (P ≤ 0.05). Moreover, heart lesion scores increased with T2D but decreased with HIIT, along with a reduction in fibrosis percentage (P ≤ 0.05). The results of this study suggest that the cardioprotective effects of HIIT on the diabetic heart may be mediated by the modulation of ATP-releasing channels. This modulation may lead to a reduction in inflammation and apoptosis, improve cardiac function, and attenuate cardiac injury and fibrosis.
Correlation of shear-wave elastography stiffness and apparent diffusion coefficient values with tumor characteristics in breast cancer
Authors: Kwon Mi-ri , Youn Inyoung , Ko Eun Sook , Choi Seon-Hyeong 
Published: March 2024

AbstractWe aimed to investigate the correlation between shear-wave elastography (SWE) and apparent diffusion coefficient (ADC) values in breast cancer and to identify the associated characteristics. We included 91 breast cancer patients who underwent SWE and breast MRI prior to surgery between January 2016 and November 2017. We measured the lesion’s mean (Emean) and maximum (Emax) elasticities of SWE and ADC values. We evaluated the correlation between SWE, ADC values and tumor size. The mean SWE and ADC values were compared for categorical variable of the pathological/imaging characteristics. ADC values showed negative correlation with Emean (r =  − 0.315, p = 0.002) and Emax (r =  − 0.326, p = 0.002). SWE was positively correlated with tumor size (r = 0.343–0.366, p < 0.001). A higher SWE value indicated a tendency towards a higher T stage (p < 0.001). Triple-negative breast cancer showed the highest SWE values (p = 0.02). SWE were significantly higher in breast cancers with posterior enhancement, vascularity, and washout kinetics (p < 0.02). SWE stiffness and ADC values were negatively correlated in breast cancer. SWE values correlated significantly with tumor size, and were higher in triple-negative subtype and aggressive imaging characteristics.
Serial mediating effects of childhood trauma and conduct behaviors on the impact of family history among patients with alcohol use disorder
Authors: Han Min Jeong , Kim Shin Tae , Park Chun Il , Hwang Syung Shick , Kim Hae Won , Kang Jee In , Kim Se Joo 
Published: March 2024

AbstractFamily history (FH) of alcoholism increases the risk of alcohol use disorder (AUD); however, the contribution of childhood trauma (CT) in this respect remains unclear. This study investigated the relationship between FH and AUD-related clinical characteristics (social onset, antisocial tendency, and severity of problematic alcohol consumption) through the mediating effects of childhood trauma (CT) and conduct behaviors (CB) in a Korean male population with AUD. A total of 304 patients hospitalized for AUD at 16 psychiatric hospitals completed standardized questionnaires, including self-rated scales. Mediation analyses were performed using the SPSS macro PROCESS. Individuals with positive FH (133, 44%) had greater CT and CB and more severe AUD-related clinical characteristics than those without FH (171, 56%). In the present serial mediation model, FH had significant direct and indirect effects on AUD-related clinical characteristics through CT and CB. Indirect effects were 21.3% for social onset, 46.3%, antisocial tendency, and 37.9% for problematic drinking. FH directly contributed to AUD-related clinical characteristics, and CT and CB played mediating roles. This highlights the importance of careful intervention and surveillance of adverse childhood experiences and conduct disorder to prevent and mitigate alcohol-related problems in individuals with FH of AUD.
The complete mitochondrial genome of Leucoptera coffeella (Lepidoptera: Lyonetiidae) and phylogenetic relationships within the Yponomeutoidea superfamily
Authors: Pereira dos Santos Mateus , Zotta Mota Ana Paula , Coiti Togawa Roberto , Florencio Martins Natalia , Fabricio de Melo Bellard do Nascime Eliza , Lucena Vivian Santos , Castellani Maria Aparecida , Saliba Albuquerque Erika Valéria , Hilliou Frédérique 
Published: March 2024

AbstractThe coffee leaf miner (Leucoptera coffeella) is one of the major pests of coffee crops in the neotropical regions, and causes major economic losses. Few molecular data are available to identify this pest and advances in the knowledge of the genome of L. coffeella will contribute to improving pest identification and also clarify taxonomy of this microlepidoptera. L. coffeella DNA was extracted and sequenced using PacBio HiFi technology. Here we report the complete L. coffeella circular mitochondrial genome (16,407 bp) assembled using Aladin software. We found a total of 37 genes, including 13 protein-coding genes (PCGs), 22 transfer RNA genes (tRNAs), 2 ribosomal RNA genes (rRNAs) and an A + T rich-region and a D-loop. The L. coffeella mitochondrial gene organization is highly conserved with similarities to lepidopteran mitochondrial gene rearrangements (trnM-trnI-trnQ). We concatenated the 13 PCG to construct a phylogenetic tree and inferred the relationship between L. coffeella and other lepidopteran species. L. coffeella is found in the Lyonetiidae clade together with L. malifoliella and Lyonetia clerkella, both leaf miners. Interestingly, this clade is assigned in the Yponomeutoidea superfamily together with Gracillariidae, and both superfamilies displayed species with leaf-mining feeding habits.
Fully connected-convolutional (FC-CNN) neural network based on hyperspectral images for rapid identification of P. ginseng growth years
Authors: Chen Xingfeng , Du Hejuan , Liu Yun , Shi Tingting , Li Jiaguo , Liu Jun , Zhao Limin , Liu Shu 
Published: March 2024

AbstractP. ginseng is a precious traditional Chinese functional food, which is used for both medicinal and food purposes, and has various effects such as immunomodulation, anti-tumor and anti-oxidation. The growth year of P. ginseng has an important impact on its medicinal and economic values. Fast and nondestructive identification of the growth year of P. ginseng is crucial for its quality evaluation. In this paper, we propose a FC-CNN network that incorporates spectral and spatial features of hyperspectral images to characterize P. ginseng from different growth years. The importance ranking of the spectra was obtained using the random forest method for optimal band selection. Based on the hyperspectral reflectance data of P. ginseng after radiometric calibration and the images of the best five VNIR bands and five SWIR bands selected, the year-by-year identification of P. ginseng age and its identification experiments for food and medicinal purposes were conducted, and the FC-CNN network and its FCNN and CNN branch networks were tested and compared in terms of their effectiveness in the identification of P. ginseng growth years. It has been experimentally verified that the best year-by-year recognition was achieved by utilizing images from five visible and near-infrared important bands and all spectral curves, and the recognition accuracy of food and medicinal use reached 100%. The FC-CNN network is significantly better than its branching model in the effect of edible and medicinal identification. The results show that for P. ginseng growth year identification, VNIR images have much more useful information than SWIR images. Meanwhile, the FC-CNN network utilizing the spectral and spatial features of hyperspectral images is an effective method for the identification of P. ginseng growth year.
Empowering women in sustainable agriculture
Authors: Fertő Imre , Bojnec Štefan 
Published: March 2024

AbstractThe agricultural and rural development policy seeks to facilitate the transition towards environmentally sustainable and climate-neutral agricultural practices, with a focus on human capital, knowledge, and innovation. Gender equality can play a significant role in promoting environmentally sustainable practices in the agricultural sector, particularly through the adoption and implementation of agri-environment-climate schemes (AECS) in the context of farm, agricultural, and rural development. We examine the presence of gender bias in the adoption intensity of AECS by utilising farm-level data from Slovenia. We find that women on Slovenian farms engage in the adoption of AECS and receive subsidies, despite the presence of a gender gap in various agricultural factor endowment variables that typically favour men. The results of this study provide evidence in favour of promoting greater involvement and empowerment of women in the fields of green technology applications and green entrepreneurship, particularly with AECS practices.
Effects of non-landslide sampling strategies on machine learning models in landslide susceptibility mapping
Authors: Gu Tengfei , Duan Ping , Wang Mingguo , Li Jia , Zhang Yanke 
Published: March 2024

AbstractThis study aims to explore the effects of different non-landslide sampling strategies on machine learning models in landslide susceptibility mapping. Non-landslide samples are inherently uncertain, and the selection of non-landslide samples may suffer from issues such as noisy or insufficient regional representations, which can affect the accuracy of the results. In this study, a positive-unlabeled (PU) bagging semi-supervised learning method was introduced for non-landslide sample selection. In addition, buffer control sampling (BCS) and K-means (KM) clustering were applied for comparative analysis. Based on landslide data from Qiaojia County, Yunnan Province, China, collected in 2014, three machine learning models, namely, random forest, support vector machine, and CatBoost, were used for landslide susceptibility mapping. The results show that the quality of samples selected using different non-landslide sampling strategies varies significantly. Overall, the quality of non-landslide samples selected using the PU bagging method is superior, and this method performs best when combined with CatBoost for predicting (AUC = 0.897) landslides in very high and high susceptibility zones (82.14%). Additionally, the KM results indicated overfitting, displaying high accuracy for validation but poor statistical outcomes for zoning. The BCS results were the worst.
A warming climate will make Australian soil a net emitter of atmospheric CO2
Authors: Viscarra Rossel R. A. , Zhang M. , Behrens T. , Webster R. 
Published: March 2024

AbstractUnderstanding the change in soil organic carbon (C) stock in a warmer climate and the effect of current land management on that stock is critical for soil and environmental conservation and climate policy. By simulation modeling, we predicted changes in Australia’s soil organic C stock from 2010 to 2100. These vary from losses of 0.014–0.077 t C ha−1 year−1 between 2020 and 2045 and 0.013–0.047 t C ha−1 year−1 between 2070 and 2100, under increasing emissions of greenhouse gases and temperature. Thus, Australian soil will be a net emitter of CO2. Depending on the future socio-economic conditions, we predict that croplands will accrue as much as 0.19 t C ha−1 year−1 between 2020 and 2045 due to their management, but accrual will decrease with warming and increased emissions by 2070–2100. The gains will be too small to counteract the losses of C from the larger areas of rangelands and coastal regions that are more sensitive to a warmer climate. In principle, prudent management of the rangelands, for example, improving grazing management and regenerating biodiverse, endemic native plant communities, could sequester more C and mitigate the loss; in practice, it may be more difficult, requiring innovation, interdisciplinary science, cultural awareness and effective policies.
A remote digital memory composite to detect cognitive impairment in memory clinic samples in unsupervised settings using mobile devices
Authors: Berron David , Glanz Wenzel , Clark Lindsay , Basche Kristin , Grande Xenia , Güsten Jeremie , Billette Ornella V. , Hempen Ina , Naveed Muhammad Hashim , Diersch Nadine , Butryn Michaela , Spottke Annika , Buerger Katharina , Perneczky Robert , Schneider Anja , Teipel Stefan , Wiltfang Jens , Johnson Sterling , Wagner Michael , Jessen Frank , Düzel Emrah 
Published: March 2024

AbstractRemote monitoring of cognition holds the promise to facilitate case-finding in clinical care and the individual detection of cognitive impairment in clinical and research settings. In the context of Alzheimer’s disease, this is particularly relevant for patients who seek medical advice due to memory problems. Here, we develop a remote digital memory composite (RDMC) score from an unsupervised remote cognitive assessment battery focused on episodic memory and long-term recall and assess its construct validity, retest reliability, and diagnostic accuracy when predicting MCI-grade impairment in a memory clinic sample and healthy controls. A total of 199 participants were recruited from three cohorts and included as healthy controls (n = 97), individuals with subjective cognitive decline (n = 59), or patients with mild cognitive impairment (n = 43). Participants performed cognitive assessments in a fully remote and unsupervised setting via a smartphone app. The derived RDMC score is significantly correlated with the PACC5 score across participants and demonstrates good retest reliability. Diagnostic accuracy for discriminating memory impairment from no impairment is high (cross-validated AUC = 0.83, 95% CI [0.66, 0.99]) with a sensitivity of 0.82 and a specificity of 0.72. Thus, unsupervised remote cognitive assessments implemented in the neotiv digital platform show good discrimination between cognitively impaired and unimpaired individuals, further demonstrating that it is feasible to complement the neuropsychological assessment of episodic memory with unsupervised and remote assessments on mobile devices. This contributes to recent efforts to implement remote assessment of episodic memory for case-finding and monitoring in large research studies and clinical care.
Bacterial vitamin B6 is required for post-embryonic development in C. elegans
Authors: Feng Min , Gao Baizhen , Ruiz Daniela , Garcia Luis Rene , Sun Qing 
Published: March 2024

AbstractNutritional intake influences animal growth, reproductive capacity, and survival of animals. Under nutrition deficiency, animal developmental arrest occurs as an adaptive strategy to survive. However, the nutritional basis and the underlying nutrient sensing mechanism essential for animal regrowth after developmental arrest remain to be explored. In Caenorhabditis elegans, larvae undergo early developmental arrest are stress resistant, and they require certain nutrients to recover postembryonic development. Here, we investigated the developmental arrest in C. elegans feeding on Lactiplantibacillus plantarum, and the rescue of the diapause state with trace supplementation of Escherichia coli. We performed a genome-wide screen using 3983 individual gene deletion E. coli mutants and identified E. coli genes that are indispensable for C. elegans larval growth on originally not nutritionally sufficient bacteria L. plantarum. Among these crucial genes, we confirmed E. coli pdxH, and the downstream metabolite pyridoxal 5-P (PLP, Vitamin B6) as important nutritional factors for C. elegans postembryonic development. Transcriptome results suggest that bacterial pdxH affects host development by coordinating host metabolic processes and PLP binding. Additionally, the developmental arrest induced by the L. plantarum diet in worm does not depend on the activation of FoxO/DAF-16. Altogether, these results highlight the role of microbial metabolite PLP as a crucial cofactor to restore postembryonic development in C. elegans.
Brief and intensive volcanic emissions from Ontong Java Nui heralded Oceanic Anoxic Event 1a
Authors: Matsumoto Hironao , Goto Kosuke T. , Shimoda Gen , Watanabe Yasuto , Shirai Kotaro , Tejada Maria Luisa G. , Ishikawa Akira , Ando Atsushi , Sano Takashi , Kuroda Junichiro , Suzuki Katsuhiko 
Published: March 2024

AbstractThe volcanic episode that formed Ontong Java Nui (OJN) in the western Pacific ~ 120 million-year-ago is thought to have triggered Oceanic Anoxic Event (OAE) 1a, yet the cause-effect relationship remains insufficiently understood. Here, we present a Pb-Os-C isotope dataset for tracking OJN volcanism across a sedimentary sequence containing OAE1a record in the central Pacific. Lead isotopic evidence strongly supports the deposition of OJN-sourced volcanic ash layers at this site after a paired seawater δ13Ccarb–187Os/188Os shift and before the onset of OAE1a. The δ13Ccarb–187Os/188Os shift is attributable to the signature of the initial submarine OJN eruption. The subsequent unradiogenic Pb isotope shifts could represent ash fallout from the brief, explosive subaerial/shallow-marine eruption phase accompanied by intensive volcanic degassing and emissions. The apparent time lag between explosive OJN volcanism and OAE1a is intriguing, which can be accounted for by the delayed increase in the productivity after gas emissions.
Australian human-induced native forest regeneration carbon offset projects have limited impact on changes in woody vegetation cover and carbon removals
Authors: Macintosh Andrew , Butler Don , Larraondo Pablo , Evans Megan C. , Ansell Dean , Waschka Marie , Fensham Rod , Eldridge David , Lindenmayer David , Gibbons Philip , Summerfield Paul 
Published: March 2024

AbstractCarbon offsets are a widely used climate policy instrument that can reduce mitigation costs and generate important environmental and social co-benefits. However, they can increase emissions if they lack integrity. We analysed the performance of one of the world’s largest nature-based offset types: human-induced regeneration projects under Australia’s carbon offset scheme. The projects are supposed to involve the human-induced regeneration of permanent even-aged native forests through changes in land management. We analysed 182 projects and found limited evidence of regeneration in credited areas. Changes in woody vegetation cover within the areas that have been credited also largely mirror changes in adjacent comparison areas, outside the projects, suggesting the observable changes are predominantly attributable to factors other than the project activities. The results add to the growing literature highlighting the practical limitations of offsets and the potential for offset schemes to credit abatement that is non-existent, non-additional and potentially impermanent.