bluuebunny/crossref_metadata_2025_split huggingface dataset:
Obstetric Interventions Among Native and Migrant Women: The (Over)use of Episiotomy in Portugal
Authors: Lorthe Elsa , Severo Milton , Hamwi Sousan , Rodrigues Teresa , Teixeira Cristina , Barros Henrique 
Published: March 2024

Objective: Episiotomy, defined as the incision of the perineum to enlarge the vaginal opening during childbirth, is one of the most commonly performed surgical interventions in the world. We aimed to determine if migrant status is associated with episiotomy, and if individual characteristics mediate this association.Methods: We analyzed data from the Bambino study, a national, prospective cohort of migrant and native women giving birth at a public hospital in mainland Portugal between 2017 and 2019. We included all women with vaginal delivery. The association between migrant status and episiotomy was assessed using multivariable multilevel random-effect logistic regression models. We used path analysis to quantify the direct, indirect and total effects of migrant status on episiotomy.Results: Among 3,583 women with spontaneous delivery, migrant parturients had decreased odds of episiotomy, especially those born in Africa, compared to native Portuguese women. Conversely, with instrumental delivery, migrant women had higher odds of episiotomy. Disparities in episiotomy were largely explained by maternity units’ factors, and little by maternal and fetal characteristics.Conclusion: Our results suggest non-medically justified differential episiotomy use during childbirth and highlight the importance of developing evidence-based recommendations for episiotomy use in a country with a high frequency of medical interventions during delivery.
Cyanide Insensitive Oxidase Confers Hydrogen Sulfide and Nitric Oxide Tolerance to Pseudomonas aeruginosa Aerobic Respiration
Authors: Nastasi Martina R. , Caruso Lorenzo , Giordano Francesca , Mellini Marta , Rampioni Giordano , Giuffrè Alessandro , Forte Elena 
Published: March 2024

Hydrogen sulfide (H2S) and nitric oxide (NO) are long-known inhibitors of terminal oxidases in the respiratory chain. Yet, they exert pivotal signaling roles in physiological processes, and in several bacterial pathogens have been reported to confer resistance against oxidative stress, host immune responses, and antibiotics. Pseudomonas aeruginosa, an opportunistic pathogen causing life-threatening infections that are difficult to eradicate, has a highly branched respiratory chain including four terminal oxidases of the haem-copper type (aa3, cbb3-1, cbb3-2, and bo3) and one oxidase of the bd-type (cyanide-insensitive oxidase, CIO). As Escherichia coli bd-type oxidases have been shown to be H2S-insensitive and to readily recover their activity from NO inhibition, here we tested the effect of H2S and NO on CIO by performing oxygraphic measurements on membrane preparations from P. aeruginosa PAO1 and isogenic mutants depleted of CIO only or all other terminal oxidases except CIO. We show that O2 consumption by CIO is unaltered even in the presence of high levels of H2S, and that CIO expression is enhanced and supports bacterial growth under such stressful conditions. In addition, we report that CIO is reversibly inhibited by NO, while activity recovery after NO exhaustion is full and fast, suggesting a protective role of CIO under NO stress conditions. As P. aeruginosa is exposed to H2S and NO during infection, the tolerance of CIO towards these stressors agrees with the proposed role of CIO in P. aeruginosa virulence.
Genome-Wide Analysis of the Xyloglucan Endotransglucosylase/Hydrolase (XTH) Gene Family: Expression Pattern during Magnesium Stress Treatment in the Mulberry Plant (Morus alba L.) Leaves
Authors: Danso Blessing , Ackah Michael , Jin Xin , Ayittey Derek M. , Amoako Frank Kwarteng , Zhao Weiguo 
Published: March 2024

Mulberry (Morus alba L.), a significant fruit tree crop, requires magnesium (Mg) for its optimal growth and productivity. Nonetheless, our understanding of the molecular basis underlying magnesium stress tolerance in mulberry plants remains unexplored. In our previous study, we identified several differential candidate genes associated with Mg homeostasis via transcriptome analysis, including the xyloglucan endotransglucosylase/hydrolase (XTH) gene family. The XTH gene family is crucial for plant cell wall reconstruction and stress responses. These genes have been identified and thoroughly investigated in various plant species. However, there is no research pertaining to XTH genes within the M. alba plant. This research systematically examined the M. alba XTH (MaXTH) gene family at the genomic level using a bioinformatic approach. In total, 22 MaXTH genes were discovered and contained the Glyco_hydro_16 and XET_C conserved domains. The MaXTHs were categorized into five distinct groups by their phylogenetic relationships. The gene structure possesses four exons and three introns. Furthermore, the MaXTH gene promoter analysis reveals a plethora of cis-regulatory elements, mainly stress responsiveness, phytohormone responsiveness, and growth and development. GO analysis indicated that MaXTHs encode proteins that exhibit xyloglucan xyloglucosyl transferase and hydrolase activities in addition to cell wall biogenesis as well as xyloglucan and carbohydrate metabolic processes. Moreover, a synteny analysis unveiled an evolutionary relationship between the XTH genes in M. alba and those in three other species: A. thaliana, P. trichocarpa, and Zea mays. Expression profiles from RNA-Seq data displayed distinct expression patterns of XTH genes in M. alba leaf tissue during Mg treatments. Real-time quantitative PCR analysis confirmed the expression of the MaXTH genes in Mg stress response. Overall, this research enhances our understanding of the characteristics of MaXTH gene family members and lays the foundation for future functional genomic study in M. alba.
PRINCIPLES OF FUNCTIONAL-PLANNING ORGANIZATION OF INCINERATION POWER PLANTS IN CHINA
Authors: Guo Zeyu 
Published: March 2024

At present, most countries are changing their national waste management policies from landfill disposal to recycling and reuse. In China, incineration power plants have been the first choice of disposal method because they occupy a small area, process waste quickly, reduce the amount of waste, do not pollute the environment, and have a high energy recovery rate. Nevertheless, the existing facilities are mostly monofunctional and the areas where they are located are depressive in nature. This leads to social rejection by the population and refusal to build incinerator power plants in the necessary quantity. The purpose of this article is to determine the principles of functional-planning organization of incinerator power plants in China. The existing experience of realization and designing of multifunctional incinerating power plants in China is studied, the graphic analysis of town-planning location and organization of sites is executed, the basic technological blocks, which are included in objects, are defined, functional-planning interrelations between them are established. The variants of shaping and architectural embodiment of garbage processing facilities have been studied. The result of the research is the formulation of the principles of functional-planning organization of multifunctional incineration power plants in China.
Keywords: architecture, functional-planning solutions, incineration power plant, waste, China.
Desenvolvimento de protocolos de ressuscitação cardiopulmonar pediátrica: avanços recentes
Authors: Fonseca Lucas Barros , Veloso Ana Paula Xavier , Menusi Gabrielly , Rodrigues Mariana Guimarães , Morais Wellyton Carlos Silva , Leite Bruna Verdelho , Corrêa Ana Beatriz Rezende dos Santos , Andrade Cecília Ferreira da Cunha , Moraes João Paulo Marcuzzo , Coelho Luma Santos , Santana Palloma Loyanne Pereira , Krüger Willian Lôbo , Sá Bruna Bezerra Torres de , Cruz Tamiris Horn da , Waltermann Martha Eliana 
Published: March 2024

Introdução: Cada minuto durante uma parada cardíaca é crítico, e seguir protocolos eficazes pode significar a diferença entre a vida e a morte para uma criança. Além disso, uma ressuscitação bem-sucedida pode evitar complicações neurológicas e danos irreversíveis, permitindo que a criança tenha uma recuperação completa e uma vida saudável após o evento. Objetivo: Investigar e avaliar os avanços recentes no desenvolvimento de protocolos de ressuscitação cardiopulmonar pediátrica, com foco na identificação de melhores práticas. Metodologia: Realizou-se uma revisão integrativa da literatura nas bases científicas: MEDLINE e PUBMED. Resultados e Discussões: Programas de treinamento que utilizam simulações realistas e cenários interativos têm se mostrado eficazes na capacitação de equipes multidisciplinares para lidar com emergências pediátricas de forma mais eficiente e segura. Além disso, a incorporação de tecnologias avançadas, como dispositivos de feedback em tempo real e aplicativos móveis de suporte à decisão clínica, tem sido um aspecto relevante apresentado pela literatura nos avanços recentes. Conclusão: A análise detalhada desses avanços destacou a importância da educação e treinamento contínuos, bem como a integração de tecnologias inovadoras para melhorar a eficácia e a qualidade dos cuidados prestados às crianças em emergências cardiorrespiratórias.
Técnicas de degermação e higienização das mãos
Authors: Kunz Wagner de Almeida , Anziliero Eduarda Bassi , Borghetti Vanessa Isabela , Sponchiado Leonardo Elvis , Fernandes Augusto Goldschmidt , Berto Isadora Silva Dal 
Published: March 2024

Levando-se em consideração que as mãos são ferramentas fundamentais para a execução do trabalho dos profissionais da saúde, sobretudo os dentistas, vale ressaltar que elas também são as principais formas de transmissão de patologias, visto que servem de reservatório para esses patógenos e estão em constante risco com o meio externo, como corrimão, fechaduras e torneiras, locais que geralmente estão repletos de agentes infecciosos. Por essa razão, a prática de degermação das mãos com o sabão comum, sabão antisséptico ou álcool gel, deve ser realizada com eficiência antes de procedimentos clínicos em consultórios e centros cirúrgicos , a fim de evitar que esses patógenos causem danos ao paciente e ao profissional. Objetivos: verificar a presença de microrganismos após a lavagem das mãos com o uso de diferentes substâncias. Materiais e métodos: Para a realização da cultura utilizou-se inóculo e um meio de cultura, foi utilizado o Ágar Mueller Hinton que permite o crescimento e multiplicação de microrganismos. Foi introduzido artificialmente microrganismos presentes em amostras coletadas da superfície das mãos em um meio de cultura esterilizado, com a finalidade de observação da multiplicação de bactérias que se encontravam nessa superfície.Após o período de incubação, retornamos ao laboratório para verificar os resultados obtidos com a experiência. Constatou-se que a lavagem apenas com água não é efetiva, pois a microbiota transitória das mãos não é removida, convém salientar que é menos efetiva que a não lavagem das mãos, uma vez que espalha os microrganismos por toda superfície. Na lavagem apenas com sabão comum a microbiota residente não é removida, apenas a transitória. O uso de álcool gel 70% mostrou redução e inativação da carga microbiana, porém a sujidade não é removida. A lavagem mais adequada e que melhor mostrou resultados foi a lavagem com sabão antisséptico, pois remove a microbiota transitória a residente, trazendo segurança ao profissional e ao paciente durante a realização de procedimentos.Dessa forma, ficou evidente o quão imprescindível é a lavagem correta das mãos que é a maneira mais eficaz de prevenir a propagação de doenças transmissíveis.
Modelos de integração multiprofissional em saúde mental na atenção primária: uma revisão bibliográfica
Authors: Gomes Luara Bela Rocha , Cordeiro Júnior Carlos Wagner Leal , Stefani Marcio Antônio , Marins Renan Augusto , Andrade Jennyfer Souza , Silva Everton Willian Benevides , Melo Dandara Caroline Pinheiro , Santos Suellen Pereira dos 
Published: March 2024

Este estudo visa analisar a implementação de modelos de integração de cuidados em saúde mental na atenção primária, com foco no contexto brasileiro, identificando os principais desafios, resultados e perspectivas futuras. Realizou-se uma revisão bibliográfica abrangente, examinando estudos publicados entre 2013 e 2023 que exploraram diferentes modelos de integração de cuidados em saúde mental na atenção primária. Foram incluídos estudos originais e revisões publicados em periódicos científicos com revisão por pares em português. A busca foi conduzida em bases de dados: Biblioteca Virtual em Saúde (BVS), Scientific Electronic Library (SCIELO), Portal de Periódicos da CAPES e Google Acadêmico. Os critérios de inclusão abrangeram estudos que contribuíram para uma compreensão abrangente dos modelos de integração de cuidados em saúde mental na atenção primária. Diversos modelos de integração de cuidados em saúde mental na atenção primária foram identificados, incluindo o modelo colaborativo, consultivo e de cuidados compartilhados. No contexto brasileiro, programas como o Programa Nacional de Melhoria do Acesso e da Qualidade da Atenção Básica (PMAQ-AB) têm promovido a implementação de equipes multiprofissionais nas unidades básicas de saúde, visando oferecer cuidados integrados e descentralizados. No entanto, desafios como a falta de financiamento, escassez de recursos humanos qualificados e resistência à mudança por parte dos profissionais de saúde têm impactado a implementação efetiva desses modelos. A integração de cuidados em saúde mental na atenção primária oferece oportunidades significativas para melhorar o acesso e a qualidade dos serviços de saúde mental no Brasil. No entanto, é necessário superar desafios como a escassez de recursos e a resistência à mudança para garantir uma implementação eficaz e sustentável desses modelos. Recomenda-se mais pesquisa e inovação nesta área, juntamente com o envolvimento dos pacientes e suas famílias, para garantir uma abordagem centrada no paciente na prestação de cuidados de saúde mental na atenção primária.
Deficiency of FXII Сoagulation Factor (Hageman Factor) is a Rare Coagulopathy or a Common Laboratory Finding?
Authors: Шашок Л.В. , Кабаева Е.Н. , Цвирко Д.Г. 
Published: March 2024

В статье обсуждается роль фактора Хагемана (XII фактора свертывания крови, FXII) в тромбообразовании и формировании риска кровотечений при его дефиците. Представлены результаты исследования причин синдрома изолированно удлиненного активированного частично тромбопластинового времени АЧТВ (СИУ АЧТВ) и частоты выявления при этом дефицита FXII фактора. Установлено, что второй по частоте встречаемости причиной СИУ АЧТВ является дефицит FXII (25%), что говорит о недостаточности знаний истинной частоты встречаемости дефицита FXII. Полученные данные позволяют сделать вывод о том, что в первую очередь при положительном тесте коррекции удлиненного АЧТВ (нормализация при добавлении контрольной плазмы) и при отсутствии геморрагического синдрома необходимо исключить дефицит FXII, так как он является наиболее частой причиной нарушения свертывания крови (помимо присутствия волчаночного антикоагулянта (ВА)), удлинения АЧТВ в амбулаторной практике. Полученные результаты позволили сформировать алгоритм лабораторного диагностического поиска при синдроме изолированно удлиненного АЧТВ.
The article discusses the role of the FXII blood coagulation factor (Hageman factor) in the process of blood coagulation, its role in the formation of thrombosis and the risk of bleeding in its deficiency. The results of a study of the causes of isolated prolonged APTT syndrome (SIU APTT) and the frequency of detection of FXII factor deficiency are presented. FXII deficiency (25%) was found to be the second most common cause of IRS APTT, which indicates a lack of knowledge of the true incidence of FXII deficiency. The data obtained allow us to conclude that, first of all, with a positive test for the correction of a prolonged APTT (normalization with the addition of control plasma) and in the absence of a hemorrhagic syndrome, it is necessary to exclude FXII deficiency, since it is the most common cause, in addition to the presence of lupus anticoagulant (LA), prolongation of APTT in outpatient practice. The results obtained made it possible to develop an algorithm for laboratory diagnostic search for isolated prolonged APTT syndrome.
Thrombotic Thrombocytopenic Purpura: Etiopathogenesis, Diagnosis and Therapy (A Review)
Authors: Зуховицкая Е.В. , Кабаева Е.Н. , Цвирко Д.Г. 
Published: March 2024

Тромботическая тромбоцитопеническая пурпура – одна из тромботических микроангиопатий. В основе патогенеза заболевания лежат наследственный или, чаще, приобретенный дефицит плазменной металлопротеиназы ADAMТS-13, накопление гигантских мультимеров фактора Виллебранда, активация тромбоцитарного тромбообразования, блокада микроциркуляции в органах, тромбоцитопения потребления, микроангиопатическая гемолитическая анемия. Лабораторная диагностика тромботической тромбоцитопенической пурпуры наряду с оценкой клинической симптоматики, выявлением тромбоцитопении и лабораторных маркеров внутрисосудистого гемолиза неиммунного генеза базируется на обнаружении дефицита ADAMТS-13, наличия и титра его иммунного ингибитора. Терапия заболевания базируется на применении плазмообмена в сочетании с иммуносупрессивной терапией глюкокортикостероидами и ритуксимабом, а также на применении препаратов, блокирующих взаимодействие тромбоцитов с фактором Виллебранда.
Thrombotic thrombocytopenic purpura is one of the thrombotic microangiopathies. The pathogenesis of the disease is based on hereditary or more often acquired deficiency of plasma metalloproteinase ADAMTS-13, accumulation of giant von Willebrand factor multimers,activationofplateletthrombusformation,blockadeofmycocirculationinorgans, consumption thrombocytopenia, microangiopathic hemolytic anemia. The diagnosis of thrombotic thrombocytopenic purpura, along with the assessment of clinical symptoms, the detection of thrombocytopenia and laboratory markers of non-immune intravascular hemolysis, is based on the detection of ADAMTS-13 deficiency, the presence and titer of its immune inhibitor. Therapy of the disease is based on the use of plasma exchange in combination with immunosuppressive therapy with glucocorticosteroids and rituximab, as well as on the use of drugs that block the interaction of platelets with von Willebrand factor.
PENERAPAN PRINSIP ACTIO PAULIANA DALAM KEPAILITAN DAN PERLINDUNGAN HUKUMNYA TERHADAP PEMBELI YANG BERITIKAD BAIK
Authors: Kamilah Anita 
Published: March 2024

Covid-19 pandemic situation has had a major impact on the sustainability of the community's businesses, thus hampering them in fulfilling their responsibilities in paying their debt obligations. Actio Pauliana as an instrument in the bankruptcy law on the one hand protects the interests of creditors, but on the other hand it is necessary to pay attention to the legal protection of buyers with good intentions. This research was conducted to examine: (1) Legal protection for creditors due to:Â transfer of the object of bankruptcy; and (2) the legal consequences of canceling the sale and purchase of objects bankruptcy and its protection against buyers in good faith. The approach method used is through a normative juridical approach, descriptive analysis research specifications, which are supported by types and sources of data derived from secondary data, especially primary legal materials, secondary legal materials, and tertiary legal materials, then qualitative data analysis is carried out. The results of the study: (1) the Bankruptcy Act and the provisions of the Civil Code as general provisions provide protection to creditors due to the transfer of the object of bankruptcy through the instrument Actio Pauliana to cancel the debtor's actions are detrimental to the creditor; and (2) Good faith buyers get protection to get his right to get a guarantee of the safe and secure goods he bought, and failure to fulfill it gives the buyer the right to claim compensation. Keywords: Bankruptcy, Actio Pauliana, Good faith, Buyer Protection
TINDAKAN PENCEMARAN NAMA BAIK DAN PENGHINAAN MELALUI MEDIA ELEKTRONIK
Authors: Rusman Rusman , Mutmainah S Fauziyyah 
Published: March 2024

The development of technology and information has changed human lifestyles, including through technology and information facilities, humans can also access, provide information and carry out acts of defamation among human beings. As a nation that upholds human dignity and dignity, acts of defamation through technological means are included in the category of criminal acts and perpetrators of defamation have entered the legal area regulated by Law (UU) No. 19 of 2016 Amendments to Law No. 11 of 2008 concerning Information and Electronic Transactions, namely the internet as a medium for carrying out their actions. Perpetrators can be legally processed even if there is no complaint from the victim, but by referring to the Criminal Code as intended by the Law on Information and Electronic Transactions, the offense turns into a complaint offense (klacht delic) which requires the victim to make a complaint to the authorities.Â Keywords: Complaints, Dignity, Humiliation, Criminal, Sanctions.
PERSPEKTIF PENGEMBANGAN ANALISIS PENDEKATAN STRUKTUR DALAM PERJANJIAN PENETAPAN HARGA
Authors: Azizah Azizah 
Published: March 2024

Pendekatan struktur atau analisis strukturÂ atau analisis kekuatan pasar merupakan suatu pendekatan struktur pasarÂ atau analisis struktur pasar yang memiliki ciri-ciri strategis dan berkaitan erat dengan perilaku pasar dan kinerja pasar. AnalisisÂ Â struktur pasar dapat dijadikan alternatifÂ analisis tambahan (Peraturan Komisi Pengawas Persaingan Usaha/KPPU, Nomor 4 Tahun 2011), yang dapat digunakan oleh Komisi untuk mengambil keputusan terhadap pelaku usaha yang melanggar ketentuan Pasal 5 undang-undang nomor 5 Tahun 1999 mengenai perjanjian penetapan harga. Dalam ius constituendum, hendaknya analisis ini dapat dijadikan alternatif utama bagi KPPU, sehingga akan meminimalisir putusan yang ditolak di tingkat Pengadilan negeri maupun mahkamah agung.
STUDI TENTANG PENERAPAN ASAS VERHANDLUNGS MAXIME DALAM PEMERIKSAAN PERKARA PERDATA
Authors: Nugroho Sigit Dwi , Septiningsih Ismawati , Kurniawan Itok Dwi 
Published: March 2024

In civil procedural law there are principles that must be met, one of which is fulfilling the legal principle, the Verhandlungs Maxime principle has the understanding that the scope or main area of the dispute submitted to the judge for examination is basically determined by the parties to the case and not by the judge. In practice, if the Verhandlungs Maxime principle is applied absolutely in trying cases, it can cause the principle of justice or the principle of expediency not to be fulfilled. There is a need for research related to the application of the Verhandlungs Maxime principle in the examination of civil cases to determine the scope of this principle. The research method used in the preparation of this study is a normative juridical method. Judges in deciding a case must pay attention to the Verhandlungs Maxime principle so that the resulting decision is not considered Ultra Petita, but the judge has the freedom to decide outside the subject of the dispute submitted by the parties based on the theory of legal objectives by Gustav Radbruch, Law Number 48 of 2009 concerning Power Judiciary, and Supreme Court Jurisprudence. An understanding is needed regarding the arrangement and application of the Verhandlungs Maxime principle in the Civil Procedure Code, other regulations related to the verhandlungs maxime principle, and the development of the application of the principle so that there is a uniform understanding of the verhandlungs maxime principle.Â Keywords: Civil Case, Legal Principles, Verhandlungs Maxime.