bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relevant dimensions to give meaning to pension decisions
Authors: Strikwerda Jelle , Holleman Bregje , Hoeken Hans 
Published: March 2024

Abstract
Pension participants face complex decisions. Information about the decision alternatives often contains the exact monetary amounts associated with the alternatives. Grounded in Fuzzy-Trace Theory (FTT), we argue that informed decision making requires participants to (accurately) understand meaningful differences between decision alternatives, rather than to rely on purely numerical differences in amounts. The objective of this study was to identify, for three decisions Dutch participants can make regarding their old-age pension, what dimensions participants take into account when giving meaning to the decision alternatives. We conducted 39 semi-structured in-depth interviews with Dutch pension participants in which we discussed the considerations of participants to choose for the decision alternatives. These interviews were analyzed using thematic analysis. Our analysis shows that a number of dimensions are taken into account, partially overlapping for the three decisions: life expectancy, (in)sufficient income, financial maximization, work–life balance, and job satisfaction. According to FTT, participants can be supported in extracting meaningful representations by providing cues about the dimensions that might be affected by the various decision alternatives. The dimensions identified in this paper can serve as a useful starting point for such support.
Toward a Microbe-Assisted Crop Production
Authors: Sessitsch Angela , Trivedi Pankaj , van der Heijden Marcel 
Published: March 2024

For a long time, microbial applications in crop production focused primarily on the symbiosis between mycorrhizal fungi and plants and the relationship between N2-fixing rhizobia and legumes. However, plant-associated microorganisms and microbiomes in general have lately gained immense attention, and the available information on the ecology and functions of microbiomes in the soil and plant environment exploded in the last decade. With this understanding, researchers as well as the industry have realized the vast potential of microorganisms to be used in agriculture and most importantly, to make farming more sustainable. Microorganisms have been shown to be applicable for plant protection and to improve plant nutrition. As a consequence, microbiome management can help to replace agrochemicals and increase environmental and human health. Furthermore, agriculture is facing various challenges related to climate change such as drought or emerging pathogens. Also, for these scenarios, microorganisms may find application to alleviate various abiotic and biotic stresses.[Formula: see text] Copyright © 2024 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license .
Increasing Sweep Gas Flow Reduces Respiratory Drive and Dyspnea in Nonintubated Venoarterial Extracorporeal Membrane Oxygenation Patients: A Pilot Study
Authors: Bureau Côme , Schmidt Matthieu , Chommeloux Juliette , Rivals Isabelle , Similowski Thomas , Hékimian Guillaume , Luyt Charles-Edouard , Niérat Marie-Cécile , Dangers Laurence , Dres Martin , Combes Alain , Morélot-Panzini Capucine , Demoule Alexandre 
Published: March 2024

Background
Data on assessment and management of dyspnea in patients on venoarterial extracorporeal membrane oxygenation (ECMO) for cardiogenic shock are lacking. The hypothesis was that increasing sweep gas flow through the venoarterial extracorporeal membrane oxygenator may decrease dyspnea in nonintubated venoarterial ECMO patients exhibiting clinically significant dyspnea, with a parallel reduction in respiratory drive.

Methods
Nonintubated, spontaneously breathing, supine patients on venoarterial ECMO for cardiogenic shock who presented with a dyspnea visual analog scale (VAS) score of greater than or equal to 40/100 mm were included. Sweep gas flow was increased up to +6 l/min by three steps of +2 l/min each. Dyspnea was assessed with the dyspnea-VAS and the Multidimensional Dyspnea Profile. The respiratory drive was assessed by the electromyographic activity of the alae nasi and parasternal muscles.

Results
A total of 21 patients were included in the study. Upon inclusion, median dyspnea-VAS was 50 (interquartile range, 45 to 60) mm, and sweep gas flow was 1.0 l/min (0.5 to 2.0). An increase in sweep gas flow significantly decreased dyspnea-VAS (50 [45 to 60] at baseline vs. 20 [10 to 30] at 6 l/min; P < 0.001). The decrease in dyspnea was greater for the sensory component of dyspnea (−50% [−43 to −75]) than for the affective and emotional components (−17% [−0 to −25] and −12% [−0 to −17]; P < 0.001). An increase in sweep gas flow significantly decreased electromyographic activity of the alae nasi and parasternal muscles (−23% [−36 to −10] and −20 [−41 to −0]; P < 0.001). There was a significant correlation between the sweep gas flow and the dyspnea-VAS (r = −0.91; 95% CI, −0.94 to −0.87), between the respiratory drive and the sensory component of dyspnea (r = 0.29; 95% CI, 0.13 to 0.44) between the respiratory drive and the affective component of dyspnea (r = 0.29; 95% CI, 0.02 to 0.54) and between the sweep gas flow and the alae nasi and parasternal (r = −0.31; 95% CI, −0.44 to −0.22; and r = −0.25; 95% CI, −0.44 to −0.16).

Conclusions
In critically ill patients with venoarterial ECMO, an increase in sweep gas flow through the oxygenation membrane decreases dyspnea, possibly mediated by a decrease in respiratory drive.

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Perceived Barriers and Strategies to Increasing the BSN-Prepared Nursing Workforce
Authors: Clark Terri A. 
Published: March 2024

ABSTRACT:
Care provided by Bachelor of Science in Nursing (BSN)-prepared Registered Nurses (RNs) has been shown to lead to more positive patient outcomes compared to care provided by non-BSN-prepared RNs. A Fall 2021 study explored barriers of requiring a BSN degree of staff nurses from the perspective of hospital and long-term care facility nurse leaders in Tennessee (N = 89), strategies to increase the number of nurses with BSNs, and association between leadership goals and the number of BSN-prepared nurses in the facilities. Seven barriers to requiring the BSN and nine strategies to increase BSNs were identified. Significant association was found between having plans to increase the number of BSN nurses and the percentage of nurses in the facility with BSN degrees.
Loving and Giving to Others
Authors: Tanasirijiranont Rattanaporn , Chawaphanth Sarinthip , Sennun Panida , Langkarpint Prathana , LeSeure Peeranuch , Rojanasupot Poonpilat , Sukkheo Theepprapin 
Published: March 2024

ABSTRACT:
The “Spirit of the Second Mile Nursing” (SSMN) has been cultivated in nurses who graduated from McCormick Faculty of Nursing, Thailand. These nurses were taught and they practice to care for clients, family members, and colleagues with compassion, consideration, love, enthusiasm, and willingness throughout the program. This study aimed to explore the SSMN concept using a Grounded Theory Methodology (GTM). The findings show that the SSMN concept is based on “Loving and Giving for others” principles. It consisted of three categories: the Spirit of the Second Mile nurse characteristics, nursing care, and consequences of the SSMN. Knowledge from this study provides nurses with a better understanding of the SSMN concept within the context of a Thai and American Christian view.
Plastic Surgery or Facial Plastic Surgery: Can the Public Tell the Difference?
Authors: Pyon Rachel E. , Sayadi Lohrasb R. , Pakvasa Mikhail , Vyas Raj M. , Wang Eric D. 
Published: March 2024

Background:
Social media and online advertising are increasingly used by plastic surgeons (PSs) to educate patients and obtain referrals, but it remains unclear whether the general public can distinguish the difference in training and accreditation among medical professionals advertising online. Our study elucidates the public’s expectations regarding the distinction between plastic surgery and facial plastic surgery.

Methods:
A survey was distributed via MTurk, an Amazon surveying service, to collect information about demographics and assumptions that would be made solely based on the terminology “facial PS” (FPS) and “PS.” Participants were restricted to those residing in the United States.

Results:
A total of 253 responses were collected. Based on the term FPS, respondents on average moderately to strongly agreed that they would expect an FPS to have completed a plastic and reconstructive surgery residency program (mean = 1.81; scale from 1= strongly agree to 5= strongly disagree) and would feel moderately to strongly misled if they visited an FPS for a consultation and later learned that the provider did not complete a plastic and reconstructive surgery residency (mean = 3.62; scale from 1 = not misled at all to 5 = extremely misled).

Conclusions:
Despite increasing advocacy by professional societies and the member societies of the American Board of Medical Specialties, this study demonstrated that the lay public is unaware of factually different training and certification pathways given similarity in nomenclature. This study was notably not designed to draw conclusions or imply superiority of one specialty, certifying board, or training model over the other.
Chronic hepatitis B baseline viral load and on-treatment liver cancer risk: A multinational cohort study of HBeAg-positive patients
Authors: Choi Won-Mook , Yip Terry Cheuk-Fung , Kim W. Ray , Yee Leland J. , Brooks-Rooney Craig , Curteis Tristan , Clark Laura J. , Jafry Zarena , Chen Chien-Hung , Chen Chi-Yi , Huang Yi-Hsiang , Jin Young-Joo , Jun Dae Won , Kim Jin-Wook , Park Neung Hwa , Peng Cheng-Yuan , Shin Hyun Phil , Shin Jung Woo , Yang Yao-Hsu , Wong Grace Lai-Hung , Lim Young-Suk 
Published: March 2024

Background and Aims:A single-nation study reported that pretreatment HBV viral load is associated with on-treatment risk of HCC in patients who are HBeAg-positive without cirrhosis and with chronic hepatitis B initiating antiviral treatment. We aimed to validate the association between baseline HBV viral load and on-treatment HCC risk in a larger, multinational cohort.Approach and Results:Using a multinational cohort from Korea, Hong Kong, and Taiwan involving 7545 adult patients with HBeAg-positive, without cirrhosis and with chronic hepatitis B who started entecavir or tenofovir treatment with baseline HBV viral load ≥5.00 log10IU/mL, HCC risk was estimated by baseline viral load. HBV viral load was analyzed as a categorical variable. During continuous antiviral treatment (median, 4.28 y), HCC developed in 200 patients (incidence rate, 0.61 per 100 person-years). Baseline HBV DNA level was independently associated with on-treatment HCC risk in a nonlinear pattern. HCC risk was lowest with the highest baseline viral load (≥8.00 log10IU/mL; incidence rate, 0.10 per 100 person-years), but increased sharply as baseline viral load decreased. The adjusted HCC risk was 8.05 times higher (95% CI, 3.34–19.35) with baseline viral load ≥6.00 and <7.00 log10IU/mL (incidence rate, 1.38 per 100 person-years) compared with high (≥8.00 log10IU/mL) baseline viral load (p<0.001).Conclusions:In a multinational cohort of adult patients with HBeAg-positive without cirrhosis and with chronic hepatitis B, baseline HBV viral load was significantly associated with HCC risk despite antiviral treatment. Patients with the highest viral load who initiated treatment had the lowest long-term risk of HCC development.
Continuous versus interrupted anastomotic technique for the Hepaticojejunostomy-a prospective cohort study
Authors: Yadav Tek Narayan , Pandit Narendra , Deo Kunal Bikram , Awale Lalijan , Neupane Durga , Adhikary Shailesh 
Published: March 2024

Background:
Interrupted sutures is the gold standard technique of Hepaticojejunostomy (HJ) for bilioenteric anastomosis. This study compares the safety and early complications of continuous and interrupted suture HJ.

Methods:
A prospective study involving all elective HJ between September 2019 and June 2021 was conducted. Patients with type IV or V biliary strictures, duct diameter <8 mm and/or associated vascular injury, and bilateral HJ were excluded. The study patients were divided into two random groups; interrupted and continuous anastomotic technique. Patient demographics, preoperative parameters including pathology (benign vs. malignant), HJ leak, suture time, and postoperative morbidity were recorded.

Results:
Total 34 patients were enrolled. Eighteen (52.9%) were into interrupted and 16 (47.1%) patients into the continuous group. Both the groups were comparable with regards to demographics, hemoglobin, serum albumin, preoperative cholangitis and biliary stenting. Total three (8.8%) patients in the entire study developed bile leak; interrupted-2 and continuous-1, which was not significant statistically (P=1.0). Similarly, total number of sutures used and the mean operating time to complete anastomosis in the continuous group was significantly lesser than the interrupted group (2.3±0.5 vs. 9.6±1.6, P<0.001) and (16.2±3.1 vs. 38.6±9.2 min, P<0.001) respectively. There were three (18.8%) re-exploration in the continuous anastomotic technique. Among them, only one re-operation was due to HJ anastomosis failure without mortality, remaining had re-exploration for bleeding (non-HJ).

Conclusions:
Both the techniques is safe with comparable morbidity. Further, continuous has an added advantage of decreased anastomotic time and cost.
Low-energy shock waves promote the cisplatin chemosensitivity of human osteosarcoma MNNG/HOS cells via the P2X7/Akt/mTOR pathway
Authors: Gai Ning , Ju Wei-na , Yu Tie-cheng , Qi Bao-chang 
Published: March 2024

Background:
The current dilemma of osteosarcoma treatment is the resistance of chemotherapeutic drugs after long-term usage, which also introduces life-threatening side effects.

Methods and results:
To minimize chemoresistance in osteosarcoma patients, the authors applied shock waves (SWs) to human osteosarcoma MNNG/HOS cells, then evaluated the cell viability and extracellular ATP levels, and further investigated the effect of SWs on cisplatin (DDP) cytotoxicity in MNNG/HOS cells. The authors’ results showed that 400 SW pulses at 0.21 mJ/mm2 exhibited little influence on the MNNG/HOS cell viability. In addition, this SW condition significantly promoted the extracellular ATP release in MNNG/HOS cells. Importantly, low-energy SWs obviously increased Akt and mammalian target of rapamycin (mTOR) phosphorylation and activation in MNNG/HOS cells, which could be partially reversed in the presence of P2X7 siRNA. The authors also found that low-energy SWs strongly increased the DDP sensitivity of MNNG/HOS cells in the absence of P2X7.

Conclusions:
For the first time, the authors found that SW therapy reduced the DDP resistance of MNNG/HOS osteosarcoma cells when the ATP receptor P2X7 was downregulated. SW therapy may provide a novel treatment strategy for chemoresistant human osteosarcoma.
Knowledge and attitude toward total knee arthroplasty among senior medical students in comparison to public population in Saudi Arabia: cross-sectional study
Authors: Makhdom Asim M. , Jan Mohammed Anwar 
Published: March 2024

Background:
Total knee arthroplasty (TKA) is currently considered one of the most common and successful orthopaedic procedures. It plays an essential role in the long-term treatment of osteoarthritis and enhances the patient’s quality of life. Very little is known about public and medical students’ perceptions of this procedure. The purpose of the current study was to assess the knowledge and attitudes toward TKA among medical students in comparison with the general population in Saudi Arabia.

Method:
A cross-sectional study was conducted between February and March 2023. Senior-year (interns and the fifth and sixth year) medical school students (Group A) as well as the general population (Group B) were surveyed online. The distributed questionnaire was divided into three main segments: demographics, knowledge, and the prognosis of TKA. The answers were statistically compared among participants.

Results:
Three hundred thirty-one participants were involved in this study, of whom 202 were from the general population and 128 were medical students. Most of the participants were males (68.3%), and the mean age was 32.95±15.22. The results were divided into three groups: demographic, knowledge, and prognosis. Medical students demonstrated a higher knowledge score (111.25±42.38) compared to the general population knowledge score (64.68±44.29), (P<0.001).

Conclusion:
Senior-year medical school students and the general population showed a low level of knowledge regarding TKA. However, the students had a better awareness of the procedure. The authors recommend frequent public education programs for the benefits of TKA. In addition, medical schools are encouraged to emphasize the benefits of TKA as a treatment choice for end-stage knee arthritis in their curriculum and training.
Effects of pain on cortical homeostatic plasticity in humans: a systematic review
Authors: Zolezzi Daniela M. , Larsen Dennis B. , McPhee Megan , Graven-Nielsen Thomas 
Published: March 2024

Abstract
Homeostatic plasticity (HP) is a negative feedback mechanism that prevents excessive facilitation or depression of cortical excitability (CE). Cortical HP responses in humans have been investigated by using 2 blocks of noninvasive brain stimulation with a no-stimulation block in between. A healthy HP response is characterized by reduced CE after 2 excitatory stimulation blocks and increased CE when using inhibitory stimulation. Conversely, impaired HP responses have been demonstrated in experimental and chronic pain conditions. Therefore, this systematic review aimed to provide an overview of the effect of pain on cortical HP in humans. Scopus, Embase, and PubMed were searched from inception until November 20, 2023. The included studies (1) compared experimental or clinical pain conditions with healthy controls, (2) induced HP using 2 blocks of stimulation with a no-stimulation interval, and (3) evaluated CE measures such as motor-evoked potentials. Four studies were included, consisting of 5 experiments and 146 participants, of whom 63 were patients with chronic pain and 48 were subjected to an experimental pain model. This systematic review found support for an HP impairment in pain compared with that in pain-free states, reflected by a lack of CE reduction after excitatory-excitatory HP induction over the primary motor cortex. Inhibitory-inhibitory HP induction did not produce a consistent HP response across studies, independent of pain or pain-free states. Standardization of HP induction protocols and outcome calculations is needed to ensure reproducibility and study comparison. Future HP studies may consider investigating sensory domains including nociception, which would further our understanding of abnormal HP regulation in pain conditions.
Reported Prices for High-Volume Hand Surgery in the Era of Price Transparency: Implications for Future Policy Iterations
Authors: Fahmy Joseph N. , Mead Mitchell , Chung William T. , Ibrahim Andrew M. , Chung Kevin C. 
Published: March 2024

Background:
In 2021, the United States enacted a law requiring hospitals to report prices for health care services. Across several health care services, poor compliance and wide variation in pricing was found. This study was performed to investigate variation in reporting and listed prices by hospital features for high-volume hand procedures, including carpal tunnel release, trigger finger release, de Quervain tenosynovitis release, and carpometacarpal arthroplasty.

Methods:
The Turquoise Health price transparency database was used to obtain listed prices and linked to hospital characteristics from the 2021 Annual American Hospital Association Survey. This study used descriptive statistics and generalized linear regression.

Results:
The analytic cohort included 2652 hospitals from across the United States. The highest rate of price reporting was in the Midwest (52% [n = 836]) and lowest in the South (39% [n = 925]). Compared with commercial insurers ($3609 [95% CI, $3414 to $3805]), public insurance rates were significantly lower (Medicare: $1588 [95% CI, $1484 to $1693], adjusted difference −$2021, P < 0.001; Medicaid: $1403 [95% CI, $1194 to $1612], adjusted difference −$2206, P < 0.001). Listed rates for self-pay patients were not statistically different from commercial rates.

Conclusions:
Although pricing for high-volume elective hand procedures is frequently reported, a high proportion of hospitals do not report prices. These data highlight the need for future transparency policy to include pricing for high-volume hand surgery to give patients the ability to make financially informed choices. These results are a valuable aid for surgeons and patients to promote financially conscious decisions.
A collaborative multidisciplinary trauma program improvement team improves VTE chemoprophylaxis guideline compliance in non-operative stable TBI
Authors: Al Tannir Abdul Hafiz , Golestani Simin , Tentis Morgan , Maring Morgan , Biesboer Elise A. , Dodgion Christopher , Murphy Patrick B. , Holena Daniel N. , Trevino Colleen M. , Peschman Jacob R. , Carver Thomas W. , Milia David J. , Schellenberg Morgan , de Moya Marc A. , Morris Rachel S. 
Published: March 2024

BACKGROUND
Delays in initiating venous thromboembolism (VTE) prophylaxis in patients suffering from traumatic brain injury (TBI) persist despite guidelines recommending early initiation. We hypothesized that the expansion of a Trauma Program Performance Improvement (PI) team will improve compliance of early (24–48 hours) initiation of VTE prophylaxis and will decrease VTE events in TBI patients.

METHODS
We performed a single-center retrospective review of all TBI patients admitted to a Level I trauma center before (2015–2016,) and after (2019–2020,) the expansion of the Trauma Performance Improvement and Patient Safety (PIPS) team and the creation of trauma process and outcome dashboards. Exclusion criteria included discharge or death within 48 hours of admission, expanding intracranial hemorrhage on CT scan, and a neurosurgical intervention (craniotomy, pressure monitor, or drains) prior to chemoprophylaxis initiation.

RESULTS
A total of 1,112 patients met the inclusion criteria, of which 54% (n = 604) were admitted after Trauma PIPS expansion. Following the addition of a dedicated PIPS nurse in the trauma program and creation of process dashboards, the time from stable CT to VTE prophylaxis initiation decreased (52 hours to 35 hours; p < 0.001) and more patients received chemoprophylaxis at 24 hours to 48 hours (59% from 36%, p < 0.001) after stable head CT. There was no significant difference in time from first head CT to stable CT (9 vs. 9 hours; p = 0.15). The Contemporary group had a lower rate of VTE events (1% vs. 4%; p < 0.001) with no increase in bleeding events (2% vs. 2%; p = 0.97). On multivariable analysis, being in the Early cohort was an independent predictor of VTE events (adjusted odds ratio, 3.74; 95% confidence interval, 1.45–6.16).

CONCLUSION
A collaborative multidisciplinary Trauma PIPS team improves guideline compliance. Initiation of VTE chemoprophylaxis within 24 hours to 48 hours of stable head CT is safe and effective.

LEVEL OF EVIDENCE
Therapeutic/Care Management; Level IV.