bluuebunny/crossref_metadata_2025_split huggingface dataset:
Paradoxical Nasal Obstruction: Analysis of Characteristics using Acoustic Rhinometry
Authors: Kim Hyo Yeol , Dhong Hun-Jong , Hong Sang Duk , Lee Hyun Jong , Cho Hyun Jin , Chung Seung Kyu 
Published: August 2007

Background The aim of this study was to determine the characteristics of acoustic rhinometric parameters in patients with paradoxical nasal obstruction. Methods The medical records of 1844 patients who had nasal septal deviation between 1998 and 2004 at our institute were assessed retrospectively. The authors selected 31 subjects for the experimental group and 256 subjects for the control group. Minimal cross-sectional area (MCA), volume, and degree of mucosal change at baseline and decongested phase were analyzed. Results MCA of the convex side in the baseline state for the experimental (paradoxical) group is wider than that for the control group (p = 0.005). Degree of mucosal change of the experimental group is smaller than that of the control group in the convex side (p = 0.001). Other parameters are similar for the two groups. Conclusion Patients with paradoxical nasal obstruction might be explained by less degree of mucosal change in the concave side of the nasal cavity during nasal cycle than the control group.
Rhinosinusitis Task Force Symptoms versus the Sinonasal Outcomes Test in Patients Evaluated for Chronic Rhinosinusitis
Authors: Ling Francis T. K. , Kountakis Stilianos E. 
Published: August 2007

Background The aim of this study was to compare Rhinosinusitis Task Force (RSTF) symptom scores with Sinonasal Outcome Test 20 (SNOT-20) in patients with chronic rhinosinusitis (CRS) and controls. Methods An analysis was performed of prospectively collected data in patients with CRS (n = 201) and controls (n = 100). The severity of individual RSTF major and minor symptom scores graded on a visual analog scale and total symptom scores were compared between the two groups. Correlation of the RSTF symptoms with the SNOT-20 was performed using data collected from the CRS group at baseline and at 1 year postoperatively. Results CRS patients had higher RSTF symptom scores compared with control patients when asked to rate the severity of nasal obstruction, facial pain/pressure, facial congestion, alteration of smell, nasal discharge, postnasal drip, headache, halitosis, fatigue, cough, and ear pain (p < 0.005). No statistically significant difference was seen for the symptoms of dental pain and fever. Total RSTF scores were 54.5 ± 1.9 in CRS patients versus 23.4 ± 3.0 in controls. Total SNOT-20 scores were 28.7 ± 0.8 in CRS patients versus 15.2 ± 0.6 in controls. In CRS patients, total RSTF scores correlated with total SNOT-20 scores at baseline (r = 0.36; p < 0.0001) and 1-year postoperatively (r = 0.37; p < 0.0001). Conclusion Total RSTF symptom scores are significantly different in patients with chronic rhinosinusitis compared with those without this disease. The total RSTF symptom scores also correlate with a validated outcome measures instrument.
Investigation of Fungi in Massive Nasal Polyps: Microscopy, Culture, Polymerase-Chain Reaction, and Serology
Authors: Aydil Utku , Kalkancı Ayşe , Ceylan Alper , Berk Elife , Kuştimur Semra , Uslu Sabri 
Published: August 2007

Background Although some clues exist about the causative relationship of fungi and chronic rhinosinusitis, the relationship of nasal polyps and fungi has not been enlightened. The purpose of this study was to determine whether a relationship exists between fungi and massive nasal polyps and to evaluate current available diagnostic techniques for detection of fungi. Methods Thirty cases of massive nasal polyposis (NP) were evaluated prospectively for fungal evidence and were compared with 18 cases of concha bullosa based on direct microscopy, fungal culture, serology, polymerase chain reaction (PCR), and sequencing. Results Fungal colonization was detected in 15 (50.0%) of the cases with massive NP, but only in 2 (11.1%) of the cases with concha bullosa. A significant difference was found between the study and the control groups in terms of fungal existence (p < 0.016). Direct microscopy was positive in 14 (46.7%) and 1 (5.6%) of the cases; fungal culture was positive in 8 (26.7%) and 4 (22.2%) of the cases; serology was positive in 9 (30.0%) and 2 (11.1%) of the cases; PCR was positive in 18 (60.0%) and 6 (33.3%) of the cases with massive NP and concha bullosa, respectively. Conclusion Fungal colonization was found to be more common in massive NP patients compared with the control group. According to our results, microscopy and PCR were most sensitive techniques for detection of fungi.
Risk Factors for Recurrent Sinus Surgery in Cystic Fibrosis: Review of a Decade of Experience
Authors: Becker Samuel S. , de Alarcon Alessandro , Bomeli Steven R. , Han Joseph K. , Gross Charles W. 
Published: August 2007

Background Patients with cystic fibrosis (CF) who undergo endoscopic sinus surgery often require multiple revision procedures. Our objective was to identify risk factors for revision sinus surgery in patients with CF, to better identify this subset of patients who might be better suited for alternative interventions at their initial procedure. Methods Patients with CF who presented to our academic tertiary care sinus clinic between 1994 and 2003 were reviewed. Data were collected from CT scans using the Lund-Mackay scale. Data are collected on demographics, comorbidities, CF genotype, number and type of sinus surgeries, and pulmonary function tests. Results Eighty-one patients met inclusion criteria. Fifty patients were <18 years old at presentation. Forty-one patients were Δ508 homozygotes, 32 patients were Δ508 heterozygotes, and 5 patients were non-Δ508 heterozygotes. Respiratory comorbidities were asthma alone (28%) and aspirin triad (5%). Eighteen (22%) patients either smoked or lived with smokers. The mean Lund-Mackay score before the initial surgery was 16. Twenty patients were treated with medication only; 35 patients underwent 1 surgery; 14 patients underwent 2 surgeries; 8 patients underwent 3 surgeries; 2 patients underwent 4 surgeries; and 2 patients underwent 5 surgeries. Patients with higher Lund-Mackay scores at their initial CT were more likely to undergo repeat surgeries (p < 0.05). Conclusion CF patients with high Lund-Mackay scores at their initial surgery are more likely to undergo several revision surgeries. These patients should be considered for more alternative initial management of their sinuses.
Percutaneous Root Osteotomy for correction of the Deviated Nose
Authors: Jang Yong Ju , Wang Jong Hwan , Sinha Vikas , Lee Bong-Jae 
Published: August 2007

Background This study describes the use of percutaneous root osteotomy near the intercanthal level for correction of deviated noses. This procedure provides complete mobilization of the midline bony septum. The study analyzed outcomes in patients undergoing this procedure. Methods The study retrospectively reviewed 50 patients who underwent corrective rhinoplasty involving a percutaneous root osteotomy. Two independent rhinoplastic surgeons assessed treatment outcomes by comparing pre- and postoperative photographs. Complications associated with the procedure were assessed also. Results Postoperative photographs showed the outcome was excellent in 42 cases (84%), good in 2 cases (4%), fair in 4 cases (8%), and no change in the “central area” in 2 cases (4%). No cases showed a poor or worsening outcome, and there were no complications such as visible scarring or osteotomy site depressions. Conclusions Percutaneous root osteotomy appears to be a valuable adjunct procedure for correction of deviated noses.
The Role of Anti-IgE Immunoglobulin Therapy in Nasal Polyposis: A Pilot Study
Authors: Penn Renee , Mikula Suzette 
Published: August 2007

Background Although the etiology of nasal polyposis (NP) remains unknown, emerging evidence showing elevated local IgE levels and eosinophilic infiltration suggests an allergic etiology. Given this evidence, this pilot study examined whether anti-IgE therapy is efficacious in the treatment of NP. Methods Data were retrospectively collected on two groups of patients with atopic asthma and NP who underwent endoscopic sinus surgery (ESS), including a control group (n = 4) and an anti-IgE treatment group (n = 4), who received the anti-IgE agent, omalizumab, postoperatively. Both groups were evaluated by sinus computed tomography (CT) and nasal endoscopic examination, and comparisons were made between the groups with respect to differences in the recurrence of NP after ESS. Results Collectively, the subjects showed a direct relationship between NP severity and pretreatment total serum IgE levels. Preoperatively, there were no differences between the groups with regard to their total serum IgE levels, sinus CT scores, and endoscopically determined NP scores. Relative to corresponding preoperative values, there was no significant improvement in the sinus CT scores in either treatment group postoperatively. In contrast, relative to preoperative values, the nasal polyp scores significantly improved in the anti-IgE group, whereas the control group showed no significant improvement. Conclusion This pilot study provides new evidence establishing that (1) endoscopic NP severity directly correlates to total serum IgE levels and (2) inclusion of anti-IgE therapy in the postpolypectomy management of atopic asthmatic individuals may reduce the severity of NP recurrence.
Game-based Exercises for Dynamic Short-Sitting Balance Rehabilitation of People With Chronic Spinal Cord and Traumatic Brain Injuries
Authors: Betker Aimee L , Desai Ankur , Nett Cristabel , Kapadia Naaz , Szturm Tony 
Published: August 2007

Background and Purpose
Goal-oriented, task-specific training has been shown to improve function; however, it can be difficult to maintain patient interest. This report describes a rehabilitation protocol for the maintenance of balance in a short-sitting position following spinal cord and head injuries by use of a center-of-pressure–controlled video game–based tool. The scientific justification for the selected treatment is discussed.

Case Descriptions
Three adults were treated: 1 young adult with spina bifida (T10 and L1–L2), 1 middle-aged adult with complete paraplegia (complete lesion at T11–L1), and 1 middle-aged adult with traumatic brain injury. All patients used wheelchairs full-time.

Outcomes
The patients showed increased motivation to perform the game-based exercises and increased dynamic short-sitting balance.

Discussion
The patients exhibited increases in practice volume and attention span during training with the game-based tool. In addition, they demonstrated substantial improvements in dynamic balance control. These observations indicate that a video game–based exercise approach can have a substantial positive effect by improving dynamic short-sitting balance.
Cognitive-Behavioural TreatmentFor Women Who Binge Eat
Authors: Shelley-Ummenhofer Jill , MacMillan Peter D. 
Published: August 2007

Purpose: A dietitian-administered, shortened form of the Apple and Agras cognitive-behavioural therapy (CBT) method was evaluated in a group setting to determine its effect on improving obese women's self-esteem and reducing binge-eating behaviours, depression, and negative body image.Methods: Participants were recruited through newspaper and radio advertisements. Respondents who met study selection criteria were randomly assigned to either a CBT group (n=13) or a delayed group (D-CBT) (n=9). The treatment was administered over six weekly sessions to the CBT group, and then twice weekly over three weeks to the D-CBT group. Two measures of bingeing behaviour (severity and frequency), three measures of mood (depression, body image, and self-esteem), and body weight were assessed.Results: The intervention did not result in any changes in body weight. There were statistically significant and clinically important changes after treatment (p<0.05) for all five measures. Binge-eating severity and frequency decreased, depression decreased, body image improved, and self-esteem improved. All changes were greater in the six-week treatment group.Conclusions: The dietitian-administered, group setting CBT program is effective for reducing binge eating and improving emotional state in obese women.
Mandatory Folic Acid Fortification: In Newfoundland and Labrador
Authors: Roebothan Barbara V. , Carmichael Joy , Barter Valerie , Aucoin Jane , Murphy Madonna 
Published: August 2007

Purpose: Dietary folic acid (FA) intakes were analyzed in random samples of 302 young women (aged 18 to 34) and 337 seniors (aged 65 to 74) residing in Newfoundland and Labrador (NL). The analyses were an attempt to estimate the amount of FA they would consume solely because of mandatory fortification of foods. Methods: Secondary analysis was performed on raw data collected through single 24-hour recalls as part of a larger study. Results: The dietary FA contributed by fortified foods eaten in the specified amounts was estimated to be 136 to 148 mcg/day (226 to 247 DFE/day) for young women and 151 to 160 mcg/day (252 to 267 DFE/day) for seniors. Most of this FA was contributed to the diet by enriched white flour. Conclusions: Mandatory fortification of foods appears to have improved the total mean intake of folate by young women and seniors residing in NL.
Rural Consumers’ Attitudes: Towards Nutrition Labelling
Authors: Lindhorst Kathleen , Corby Lynda , Roberts Susan , Zeiler Sharon 
Published: August 2007

Purpose: Consumer workshops in rural and remote locations were evaluated for their efficacy in changing participants’ selfperceived attitudes and behaviours related to nutrition labelling. Methods: Project-trained community health educators used pilot-tested workshop resources to facilitate 18 workshops across the country. Participants completed pre-workshop questionnaires to permit the identification of demographic characteristics and attitudes and behaviours related to nutrition labelling at pointof- purchase. Results: The majority of the 259 consumers who submitted questionnaires were women (81%), and aged 35 to 54 (35%); 51% reported more than a high school education and 34% had less than $25,000 as a yearly family income. Self-perceived attitudes and behaviours related to nutrition labelling differed only slightly by family income before the workshop. Workshops were rated positively (mode=4 [range 2 to 5]). Thirty-five consumers were surveyed three months after the workshop; the majority were women (89%), were aged 35 to 54 (43%), and had completed high school (51%). Self-perceived attitudes and behaviours for all respondents (n=35) had improved. Use of acquired knowledge and skills at point-of-purchase was high for all respondents (mode=4 [range 2 to 5]; five-point Likert scale). Conclusions: Providing in-person consumer workshops with pilot-tested materials in rural and remote locations had positive impacts on attitudes and behaviours related to the use of nutrition labelling.
Genome and RNA sequencing boost neuromuscular diagnoses to 62% from 34% with exome sequencing alone
Authors: Marchant Rhett G. , Bryen Samantha J. , Bahlo Melanie , Cairns Anita , Chao Katherine R. , Corbett Alastair , Davis Mark R. , Ganesh Vijay S. , Ghaoui Roula , Jones Kristi J. , Kornberg Andrew J. , Lek Monkol , Liang Christina , MacArthur Daniel G. , Oates Emily C. , O'Donnell‐Luria Anne , O'Grady Gina L. , Osei‐Owusu Ikeoluwa A. , Rafehi Haloom , Reddel Stephen W. , Roxburgh Richard H. , Ryan Monique M. , Sandaradura Sarah A. , Scott Liam W. , Valkanas Elise , Weisburd Ben , Young Helen , Evesson Frances J. , Waddell Leigh B. , Cooper Sandra T. 
Published: March 2024

AbstractObjectiveMost families with heritable neuromuscular disorders do not receive a molecular diagnosis. Here we evaluate diagnostic utility of exome, genome, RNA sequencing, and protein studies and provide evidence‐based recommendations for their integration into practice.MethodsIn total, 247 families with suspected monogenic neuromuscular disorders who remained without a genetic diagnosis after standard diagnostic investigations underwent research‐led massively parallel sequencing: neuromuscular disorder gene panel, exome, genome, and/or RNA sequencing to identify causal variants. Protein and RNA studies were also deployed when required.ResultsIntegration of exome sequencing and auxiliary genome, RNA and/or protein studies identified causal or likely causal variants in 62% (152 out of 247) of families. Exome sequencing alone informed 55% (83 out of 152) of diagnoses, with remaining diagnoses (45%; 69 out of 152) requiring genome sequencing, RNA and/or protein studies to identify variants and/or support pathogenicity. Arrestingly, novel disease genes accounted for <4% (6 out of 152) of diagnoses while 36.2% of solved families (55 out of 152) harbored at least one splice‐altering or structural variant in a known neuromuscular disorder gene. We posit that contemporary neuromuscular disorder gene‐panel sequencing could likely provide 66% (100 out of 152) of our diagnoses today.InterpretationOur results emphasize thorough clinical phenotyping to enable deep scrutiny of all rare genetic variation in phenotypically consistent genes. Post‐exome auxiliary investigations extended our diagnostic yield by 81% overall (34–62%). We present a diagnostic algorithm that details deployment of genomic and auxiliary investigations to obtain these diagnoses today most effectively. We hope this provides a practical guide for clinicians as they gain greater access to clinical genome and transcriptome sequencing.
Highly Conductive Doped Fluoride Solid Electrolytes with Solidified Ionic Liquid to Enable Reversible FeF3 Conversion Solid State Batteries
Authors: Hu Jiulin , Lei Meng , Zhu Chenxi , Zhang Bo , Li Chilin 
Published: March 2024

AbstractSolid‐state lithium metal batteries based on fluorinated solid electrolytes have attracted attention due to their safety and stability advantages. However, the fluoride solid electrolytes face the problem of relatively low Li‐ion conductivity due to the lacking of suitable structural prototypes and their corresponding modulation modes. In this work, a chlorine‐doped fluoride solid electrolyte Li3AlF5.87Cl0.13 is developed with high ionic conductivity by thermal fluorination and weak chlorination of mixed ionic liquids. The Cl anion is doped into the cryolite‐like open framework structure, and the electrolyte particle boundaries are decorated by solidified thin‐layer (≈2 nm) ionic liquid. Both the bulk and interface modifications enable the improvement of Li‐ion conductivity to 2 × 10−4 S cm−1 at 30 °C, which is the highest level among fluoride solid electrolytes. The Li3AlF5.87Cl0.13 with residual solidified ionic liquid shows the excellent stability of interface contact with Li metal, and the corresponding Li symmetric cell exhibits a small overvoltage (≈100 mV) with outstanding cycle life (at least 500 h). For the first time, a conversion‐type solid‐state Li/FeF3 battery is developed based on this fluoride electrolyte, delivering a reversible capacity as high as 430 mAh g−1. The existence of natural F‐rich interface promotes the conversion reaction reversibility of FeF3 cathode.
Molecular Fe─N4 Moieties Coupled with Atomic Co─N4 Sites Toward Improved Oxygen Reduction Performance
Authors: Xie Peng‐Fei , Zhong Hong , Fang Lingzhe , Lyu Zhaoyuan , Yu Wan‐Jing , Li Tao , Lee Jiyoung , Shin Hamin , Beckman Scott P. , Lin Yuehe , Ding Shichao , Kim Il‐Doo , Li Jin‐Cheng 
Published: March 2024

AbstractResearch on high‐efficiency and cost‐efficient catalysts for oxygen reduction reaction (ORR) is still a vital but challenging issue for commercializing metal–air batteries. Herein, a single‐molecule/atom hybrid catalyst is developed to boost the ORR, in which iron phthalocyanine molecules containing molecular Fe─N4 moieties couple with atomic Co─N4 sites on the surface of polyhedral carbon. Density functional theory calculations reveal that face‐to‐face laminated construction of Fe─N4 and Co─N4 in the hybrid catalyst can effectively modulate the electronic structure of active iron atoms and reduce the energy barrier of the rate‐determining step for ORR. As a result, this hybrid catalyst demonstrates excellent ORR performance, featuring a half‐wave potential of 0.904 V, a peak power density of 238.3 mW cm−2 for zinc–air battery, and outstanding electrocatalytic stability. This work offers a distinctive and robust molecular/atomic engineering approach to creating efficient electrocatalysts, advancing the fields of metal–air batteries.
Boosting Ion Diffusion Kinetics of MXene Inks with Water‐in‐Salt Electrolyte for Screen‐Printed Micro‐Supercapacitors
Authors: Wang Yihan , Yuan Yuxun , Geng HuaYun , Yang Weiqing , Chen Xiangrong 
Published: March 2024

AbstractFlexible wearable electronics are in urgent need of advanced micro‐energy storage devices. MXenes are widely used in supercapacitors because of their excellent conductivity and hydrophilicity. Nevertheless, MXene‐based supercapacitors typically exhibit low capacitance and unsatisfied rate performance, particularly in the solid compact MXene film electrode with limited porosity and/or ion diffusion paths. Here, the synthesis of MXene inks with enlarged interlayer spacing for facilitated ion diffusion kinetics by intercalating lithium ions is reported. The ion‐intercalated MXene inks are further screen‐printed for scalable production of MXene‐based micro‐supercapacitors (MSCs). Benefiting from such an electrode architecture design, as well as the wide voltage window of 21 m bis(trifluoromethane)sulfonimide lithium (LiTFSI) water‐in‐salt electrolyte, the device exhibits impressive areal capacitance (252 mF cm−2), much‐improved rate performance (capacitance retention rate as high as 80%), excellent cyclic stability (retains 98.4% of initial capacitance after 10 000 cycles) and flexibility, showing great potential in the field of wearable intelligent electronics.
Multicolor Photochemical Printing Inside Polymer Matrices for Advanced Photonic Anticounterfeiting
Authors: Dong Yu , Wu Huacan , Liu Jie , Zheng Shiya , Liang Baoshuai , Zhang Chuang , Ling Yao , Wu Xiaosong , Chen Jiamao , Yu Xiaolan , Feng Shiyu , Huang Weiguo 
Published: March 2024

AbstractConventional security inks, generally directly printed on the data page surface, are vulnerable to counterfeiters, thereby raising the risk of chemical structural deciphering. In fact, polymer film‐based data pages with customized patterns embedded within polymer matrix, rather than printed on the surface, emerge as a promising solution. Therefore, the key lies in developing fluorophores offering light dose‐controlled fluorescent color inside polymer matrices. Though conventional fluorophores often suffer from photobleaching and uncontrolled photoreactions, disqualifying them for this purpose. Herein a diphenanthridinylfumaronitrile‐based phototransformers (trans‐D5) that undergoes photoisomerization and subsequent photocyclization during photopolymerization of the precursor, successively producing cis‐ and cyclo‐D5 with stepwise redshifted solid‐state emissions is developed. The resulting cyclo‐D5 exhibits up to 172 nm emission redshift in rigidifying polymer matrices, while trans‐D5 experiences a slightly blueshifted emission (≈28 nm), cis‐D5 undergoes a modest redshift (≈14 nm). The markedly different rigidochromic behaviors of three D5 molecules within polymer matrices enable multicolor photochemical printing with a broad hue ranging from 38 to 10 via an anticlockwise direction in Munsell color space, yielding indecipherable fluorescent patterns in polymer films. This work provides a new method for document protection and implements advanced security features that are unattainable with conventional inks.