bluuebunny/crossref_metadata_2025_split huggingface dataset:
Qualitätsgesicherte Behandlung in zertifizierten
Versorgungsnetzwerken von Patientinnen mit Mammakarzinom in der Region
Oberfranken: Eine Analyse auf Basis von Bayerischen
Krebsregisterdaten
Authors: Friebel Sophie , Thater Andrea , Völkel Vinzenz , Klinkhammer-Schalke Monika , Müller-Nordhorn Jacqueline , Emmert Martin 
Published: April 2024

Zusammenfassung
Zielsetzung Brustkrebs nimmt den größten Anteil von Krebsneuerkrankungen
und -sterbefällen bei Frauen in Deutschland ein. Für die Gewährleistung einer
qualitätsgesicherten Versorgung wird die Behandlung in zertifizierten
Brustkrebszentren empfohlen. Die Zielsetzung der Studie besteht in der Analyse
der onkologischen Versorgungssituation von Mammakarzinom-Patientinnen und
-Patienten aus dem Regierungsbezirk Oberfranken.
Methodik Es erfolgte eine Betrachtung des Behandlungsortes sowie des
Zertifizierungsstatus der Leistungserbringer hinsichtlich der Erstdiagnose,
Operation, Chemotherapie und Bestrahlung bei der Versorgung. Hierauf basierend
erfolgte ein Vergleich von Patientinnencharakteristika, die in zertifizierten
und nicht-zertifizierten Zentren und ihren Netzwerken behandelt wurden. Die
Auswertung erfolgte basierend auf einem Datensatz des Bayerischen Krebsregisters
(4/2017-3/2022).
Ergebnisse Die Analyse umfasste 5.545 Primärtumoren von insgesamt 5.355
Patientinnen (Alter: 64,5±14,2 Jahre; 99,2% weiblich). Die Rate der
Inanspruchnahme zertifizierter Leistungserbringer betrug 78,8% für die
Erstdiagnose, 82,6% für die Operation, 79,5% für die Chemotherapie sowie 99,6%
für die Bestrahlung. Der gewichtete Mittelwert über alle Therapiesequenzen
hinweg ergab einen Anteil von 84,3% Inanspruchnahme von Leistungserbringern
zertifizierter Versorgungsnetzwerke. Patientinnen in zertifizierten
Versorgungsnetzwerken waren in drei Therapiesequenzen signifikant jünger
(p+<+0.001). Zudem zeigte sich insbesondere für die Diagnose und Operation
ein überdurchschnittlicher Anteil von Patientinnen mit fortgeschrittenen
Tumorstadien, die in nicht-zertifizierten Versorgungsnetzwerken behandelt wurden
(p+<+0.001).
Schlussfolgerungen Es zeigten sich in Hinblick auf die
Behandlungssequenzen Differenzen beim Anteil der Patientinnen, die in
Oberfranken eine qualitätsgesicherte Behandlung in einem zertifizierten
Versorgungsnetzwerk erhalten haben. Im deutschlandweiten Vergleich zeigt das
Ergebnis für die Region Oberfranken eine durchschnittliche Inanspruchnahme
zertifizierter Versorgungsnetzwerke. Es sollte sichergestellt werden, dass
Patientinnen und Patienten eine umfassende Aufklärung über die Versorgung in
zertifizierten Einheiten erhalten.
Prüfungsthema: Angst
Authors: Schmid Eva C. 
Published: April 2024

SummaryLiebe Heilpraktikeranwärter – mit diesen Karteikarten wollen wir Sie bei der Vorbereitung auf die mündliche Heilpraktikerüberprüfung unterstützen. Viel Erfolg beim Lernen wünscht Ihnen HP Eva C. Schmid!
Frage an das Unbewusste
Authors: Saldow Reinhold 
Published: April 2024

SummaryIm Gegensatz zu gesunden Schutzreaktionen tritt neurotische Angst als seelische Hemmung in eigentlich unproblematischen Situationen auf und wirkt über diesen Weg lebensbestimmend und -verstimmend. Kreative Heilhypnose kann bislang unerkannte Ursachen aufdecken und in einem geschützten Rahmen durch Techniken wie die Arbeit mit Bildern (zum Beispiel Kinotechnik) oder der Lebensgeschichte in aktive Gestaltung überführen. Im vorgestellten Fall konnte eine Gewitterphobie durch Aufdecken und Verarbeiten der Ursachen in Trance innerhalb von 3 Sitzungen komplett überwunden werden.
Potenzen gegen die Furcht
Authors: Welsch Katja 
Published: April 2024

SummaryUnter der Vielzahl homöopathischer Angstmittel haben sich einige Arzneien besonders bewährt, hier vorgestellt: Arsenicum album, Aconitum napellus, Stramonium, Kalium bromatum, Calcium carbonicum und Phosphorus. Im ersten Fallbeispiel führt Arsenicum album bei generalisierter Angst zu einer langsamen Entspannung, im zweiten Fall verbessert Stramonium die nächtliche Angst bei einem achtjährigen Jungen. In einer weiteren Kasuistik kann die „Universalwaffe“ Calcium carbonicum Krankheits- und Höhenangst deutlich lindern, im 4. Fall ermöglichte das Breitbandmittel Phosphorus einer Patientin mit Schwäche und Ängstlichkeit den Wiedereinstieg in den Präsenzberuf.
A Retrospective Review on Dysregulated Autophagy in Polycystic Ovary
Syndrome: From Pathogenesis to Therapeutic Strategies
Authors: Zhao Yan , Zhao Xiaoxuan , Jiang Tianyue , Xi Hongyan , Jiang Yuepeng , Feng Xiaoling 
Published: April 2024

AbstractThe main purpose of this article is to explore the relationship between autophagy
and the pathological mechanism of PCOS, and to find potential therapeutic
methods that can alleviate the pathological mechanism of PCOS by targeting
autophagy. Relevant literatures were searched in the following databases,
including: PubMed, MEDLINE, Web of Science, Scopus. The search terms were
“autophagy”, “PCOS”, “polycystic ovary syndrome”, “ovulation”,
“hyperandrogenemia”, “insulin resistance”, “inflammatory state”, “circadian
rhythm” and “treatment”, which were combined according to the retrieval methods
of different databases. Through analysis, we uncovered that abnormal levels of
autophagy were closely related to abnormal ovulation, insulin resistance,
hyperandrogenemia, and low-grade inflammation in patients with PCOS. Lifestyle
intervention, melatonin, vitamin D, and probiotics, etc. were able to improve
the pathological mechanism of PCOS via targeting autophagy. In conclusion,
autophagy disorder is a key pathological mechanism in PCOS and is also a
potential target for drug development and design.
Clinical and Growth Correlates of Retinopathy of Prematurity in Preterm Infants with Surgical Necrotizing Enterocolitis and Intestinal Perforation
Authors: Garg Parvesh M. , Riddick Robin A. , Ansari Md A.Y. , Meilstrup Asha C. , Zepponi David , Smith Andrea , Mungan Nils , Shenberger Jeffrey , Hillegass William B. , Garg Padma P. 
Published: April 2024

Objective This study aimed to identify the clinical and growth parameters associated with retinopathy of prematurity (ROP) in infants with necrotizing enterocolitis (NEC) and spontaneous ileal perforation (SIP).
Study Design We conducted a retrospective cohort study that compared clinical data before and after NEC/SIP onset in neonates, categorizing by any ROP and severe ROP (type 1/2) status.
Results The analysis included 109 infants with surgical NEC/SIP. Sixty infants (60/109, 55%) were diagnosed with any ROP, 32/109 (29.3%) infants (22% type 1 and 7.3% type 2) with severe ROP. On univariate analysis, those with severe ROP (32/109, 39.5%) were of lower median gestational age (GA, 23.8 weeks [23.4, 24.6] vs. 27.3 [26.3, 29.0], p < 0.001), lower median birth weight (625 g [512, 710] vs. 935 [700, 1,180], p < 0.001) and experienced higher exposure to clinical chorioamnionitis (22.6 vs. 2.13%, p < 0.006), and later median onset of ROP diagnosis (63.0 days [47.0, 77.2] vs. 29.0 [19.0, 41.0], p < 0.001), received Penrose drain placement more commonly (19 [59.4%] vs. 16 [34.0%], p = 0.04), retained less residual small bowel (70.0 cm [63.1, 90.8] vs. 90.8 [72.0, 101], p = 0.007) following surgery, were exposed to higher FiO2 7 days after birth (p = 0.001), received ventilation longer and exposed to higher FiO2 at 2 weeks (p < 0.05) following NEC and developed acute kidney injury (AKI) more often (25 [86.2%] vs. 20 [46.5%], p = 0.002) than those without ROP. Those with severe ROP had lower length, weight for length, and head circumference z scores. In an adjusted Firth's logistic regression, GA (adjusted odds ratio [aOR] = 0.51, 95% confidence interval [CI]: [0.35, 0.76]) and diagnosis at later age (aOR = 1.08, 95% CI: [1.03, 1.13]) was shown to be significantly associated with any ROP.
Conclusion Infants who develop severe ROP following surgical NEC/SIP are likely to be younger, smaller, have been exposed to more O2, develop AKI, and grow poorly compared with those did not develop severe ROP.
Key Points
Surgical Approaches to Resection of Olfactory Groove Meningiomas: Comparative Meta-analysis of the Endoscopic Endonasal versus Transcranial and Unilateral versus Bilateral Approaches
Authors: Brown Nolan J. , Pennington Zach , Patel Saarang , Kuo Cathleen , Chakravarti Sachiv , Bui Nicholas E. , Gendreau Julian , Van Gompel Jamie J. 
Published: April 2024

Abstract
Introduction Here we systematically review the extant literature to highlight the advantages of bilateral versus unilateral approaches and endoscopic endonasal (midline) approaches versus transcranial approaches for olfactory groove meningiomas, focusing on complications, extent of resection, and local recurrence rates.
Methods Three databases were queried to identify all primary prospective trials and retrospective series comparing outcomes following endoscopic endonasal versus transcranial approaches and unilateral versus bilateral craniotomy for surgical resection of olfactory groove meningiomas. All articles were screened by two independent authors and selected for formal analysis according to predefined inclusion/exclusion criteria.
Results Seven studies comprising 288 total patients (mean age 55.0 ± 24.6 years) met criteria for inclusion. In the three comparing the endoscopic endonasal (n = 21) versus transcranial (n = 32) approaches, there was no significant difference between the two with respect to gross total resection (p = 0.34) or rates of Simpson Grade 1 resection (p = 0.69). EEA demonstrated higher rates of overall complications (p < 0.01) including postoperative infection (p = 0.03). In the four studies comparing bilateral (n = 117) versus unilateral approaches (n = 118), overall complication rates (p < 0.01) and disease recurrence (p = 0.01) were higher with bilateral approaches. All surgery-related mortalities also occurred in the bilateral cohort (n = 7, 7.14%). Gross total resection (p = 0.63) and Simpson grade (p = 0.48) were comparable between approaches. Olfaction preservation was superior for unilateral approaches (p < 0.01).
Conclusions Though the literature is limited, current evidence suggests that the endoscopic endonasal approach may be favorable over conventional craniotomy for select olfactory groove meningioma patients. Where craniotomy is used, unilateral approaches appear to reduce complications and the risk of olfaction loss.
User-Centered Design and Implementation of an Interoperable FHIR Application for Pediatric Pneumonia Prognostication in a Randomized Trial
Authors: Turer Robert W. , Gradwohl Stephen C. , Stassun Justine , Johnson Jakobi , Slagle Jason M. , Reale Carrie , Beebe Russ , Nian Hui , Zhu Yuwei , Albert Daniel , Coffman Timothy , Alaw Hala , Wilson Tom , Just Shari , Peguillan Perry , Freeman Heather , Arnold Donald H. , Martin Judith M. , Suresh Srinivasan , Coglio Scott , Hixon Ryan , Ampofo Krow , Pavia Andrew T. , Weinger Matthew B. , Williams Derek J. , Weitkamp Asli O. 
Published: April 2024

Abstract
Objectives To support a pragmatic, electronic health record (EHR)-based randomized controlled trial, we applied user-centered design (UCD) principles, evidence-based risk communication strategies, and interoperable software architecture to design, test, and deploy a prognostic tool for children in emergency departments (EDs) with pneumonia.
Methods Risk for severe in-hospital outcomes was estimated using a validated ordinal logistic regression model to classify pneumonia severity. To render the results usable for ED clinicians, we created an integrated SMART on Fast Healthcare Interoperability Resources (FHIR) web application built for interoperable use in two pediatric EDs using different EHR vendors: Epic and Cerner. We followed a UCD framework, including problem analysis and user research, conceptual design and early prototyping, user interface development, formative evaluation, and postdeployment summative evaluation.
Results Problem analysis and user research from 39 clinicians and nurses revealed user preferences for risk aversion, accessibility, and timing of risk communication. Early prototyping and iterative design incorporated evidence-based design principles, including numeracy, risk framing, and best-practice visualization techniques. After rigorous unit and end-to-end testing, the application was successfully deployed in both EDs, which facilitated enrollment, randomization, model visualization, data capture, and reporting for trial purposes.
Conclusion The successful implementation of a custom application for pneumonia prognosis and clinical trial support in two health systems on different EHRs demonstrates the importance of UCD, adherence to modern clinical data standards, and rigorous testing. Key lessons included the need for understanding users' real-world needs, regular knowledge management, application maintenance, and the recognition that FHIR applications require careful configuration for interoperability.
Network Analysis of the North American Skull Base Society Membership
Authors: Luebs John K. , Snyderman Carl H. 
Published: April 2024

Abstract
Background The membership of the North American Skull Base Society (NASBS) has grown considerably in recent years with diversity in subspecialty training, gender, and geography. The academic relationships and contributions of its membership have not been studied.
Objectives This study aimed to (1) measure academic contributions of NASBS membership; (2) identify influential nodes of academic collaboration; (3) identify opportunities for future collaboration and mentorship.
Methods Peer-reviewed publications of members of NASBS (2019 NASBS website) were identified using Scopus author name search. Network structures were constructed and analyzed using the graph-tool python library to produce a weighted coauthorship network and compute centrality measures. Visual network maps were then produced using Gephi network visualization software.
Results The coauthor network contained 952 members with found publications and 4,996 connections. A total of 846 (88.9%) members were contained in a single connected giant component; 102 members were unconnected, and 64 members had a single connection. Girvan–Newman clustering identified 267 communities, where 13 contained at least 1% of the total membership each. The three largest communities contained 23.3, 8.4, and 6.9% of members. There were 111 published members identified as women; 5.4% of women were unconnected versus 11.4% of men. Average publication count for women was 32.3 (standard deviation [SD] 38.5) versus 70.5 (SD 106) for men. Average citation count for women was 543 (SD 1,012) versus 1,389 (SD 2,893) for men.
Conclusion Network mapping of membership of the NASBS helps to visualize the academic activities and relationships of the NASBS and reveals areas of concentration and influence within the specialty.
Endoscopic Endonasal Anterior Skull Base Meningoencephalocele and Cerebrospinal Fluid Leak Repair: Our Intraoperative and Postoperative Protocol and Long-term Outcomes
Authors: Ruiz Gianna M. , Uram Zach , Strelko Oleksandr , Hossain Adnan , Ng Isaac , Patel Chirag R. , Germanwala Anand V. 
Published: April 2024

Abstract
Objective We evaluated the long-term outcomes from a single neurosurgeon and otolaryngologist team using a specific operative protocol for repair and postoperative evaluation.
Design The charts of patients undergoing endoscopic endonasal repair of meningoencephaloceles (MECs) and cerebrospinal fluid (CSF) leaks were retrospectively reviewed from 2015 to 2023. Intraoperative steps of the repair and reconstruction were analyzed. Patients' postoperative assessments and complications were analyzed.
Setting Loyola University Medical Center's electronic medical record database.
Participants Forty-three patients (32 female) aged between 11 and 81 years.
Main Outcome Measures Long-term outcomes of patients who underwent endoscopic endonasal repair of MECs and CSF leaks by a single team and protocol. We hypothesized that there would be minimal complications and no recurrences, requiring secondary operation.
Results The most common site for MECs was the cribriform plate. Lumbar drain opening pressures ranged from 10 to 35 cm H2O with 18 out of 34 patients having the lumbar drain removed immediately postoperatively. The median hospital stay was 3 days. The average length of follow-up was 3.8 years. No recurrences or secondary operations were noted in all patients. One patient had a sinonasal infection that was successfully treated. Eight patients were noted to have venous stenosis and underwent further evaluation.
Conclusion This study represents one of the largest long-term analyses of outcomes by a single team. Our specific protocol for the endoscopic endonasal repair of anterior skull base MECs and CSF leaks is safe and effective. These patients should be evaluated and treated for elevated intracranial pressure following the repair.
Outcomes following duodenectomy in patients with familial adenomatous polyposis
Authors: Aelvoet Arthur S. , Martin Isabel , Cockburn James , Cabalit Cherryl , Cuthill Victoria , Spalding Duncan , Busch Olivier , Bastiaansen Barbara A.J. , Clark Susan K. , Dekker Evelien , Latchford Andrew 
Published: April 2024

Abstract
Background and study aims Some patients with familial adenomatous
polyposis (FAP) and extensive duodenal polyposis or cancer require total duodenectomy. Regular
postoperative endoscopic surveillance of the remaining jejunum and stomach is recommended, but
little is known about the outcomes after this surgery.
Patients and methods Patients with FAP who underwent either
pancreatoduodenectomy (PD) or pancreas-preserving total duodenectomy (PPTD) were identified at
two expert centers. Data about postoperative endoscopic surveillance outcomes were collected,
as well as survival outcomes.
Results Overall, 119 patients (50% female) underwent duodenectomy
(86 PD and 33 PPTD); 100 for benign duodenal polyposis and 19 for duodenal or ampullary
cancer. Details of postoperative endoscopic surveillance were available for 88 patients (74%).
During a median follow-up of 106 months, 36 patients (41%) were diagnosed with jejunal
adenomas after duodenectomy, with a significantly higher proportion in patients who underwent
PPTD compared with patients who underwent PD (log-rank, P <
0.01). Two patients developed jejunal cancer (2%). Twenty-six patients (30%) were diagnosed
with a total of 66 gastric adenomas, of which 61% were located in the fundus/body and 39% in
the antrum. Five patients (6%) developed gastric cancer after a median of 15 years (range 6–23
years), all but one within carpeting fundic gland polyposis. Patients who underwent surgery
for cancer had worse survival than patients with benign disease and all but one patient with
postoperative gastric/jejunal cancer died.
Conclusions After duodenectomy in FAP, a considerable risk of
developing adenomas and cancer in the stomach and jejunum exists with poor cancer prognosis,
highlighting the need for close postoperative endoscopic surveillance.
Minimally-Invasive Approach in the Setting of a Malignant Primary Cardiac Tumor
Authors: Polat Emre , Stock Sina , Owais Tamer , Girdauskas Evaldas 
Published: April 2024

AbstractA 71-year-old man with dilated cardiomyopathy without clinical complaints revealed a suspicious finding in checkup. After a multimodality cardiac imaging, the suspicion of a malignant primary cardiac tumor in the left ventricle was substantiated and the patient underwent minimally-invasive cardiac surgery for tumor resection. Postoperative chemotherapy with multiple cycles of liposomal doxorubicin was established and supported by proton beam radiotherapy. Two-year follow-up revealed no disease recurrence.
Three Patients of the Early Onset Epileptic Spasms without Hypsarrhythmia
Authors: Ohshiro Ikko , Okanishi Tohru , Ohta Ryo , Ohta Kento , Arai Yuto , Kanai Sotaro , Fujimoto Ayataka , Maegaki Yoshihiro 
Published: April 2024

AbstractEpileptic spasms without hypsarrhythmia occur when patients do not display hypsarrhythmia on electroencephalogram (EEG) at the onset and throughout the clinical course. We report three patients of epileptic spasms in patients with early onset, all of whom experienced other types of seizures.We detail three patients (two boys and one girl) of epileptic spasms without hypsarrhythmia, occurring between 1 and 3 months of age, with no abnormalities detected on neurometabolic analysis and brain magnetic resonance imaging. Long-term video-EEG monitoring revealed epileptic spasms with focal onset seizures in two patients, and epileptic spasms followed by generalized tonic-clonic seizures in one patient. Hypsarrhythmia was never observed in repeated EEG examinations. Two patients achieved seizure freedom and improved development through treatment with topiramate alone or in combination with valproate, without requiring hormonal therapies or vigabatrin. The remaining patient achieved seizure freedom following administration of antiseizure medications, including topiramate, after a trial of adrenocorticotropic hormone therapy.We report the cases of three patients with early onset epileptic spasms without hypsarrhythmia. All patients achieved seizure freedom after topiramate treatment. Topiramate may be considered as a relatively effective antiseizure medication for early onset epileptic spasms without hypsarrhythmia.
How do we study misogyny in the digital age? A systematic literature review using a computational linguistic approach
Authors: Fontanella Lara , Chulvi Berta , Ignazzi Elisa , Sarra Annalina , Tontodimamma Alice 
Published: April 2024

AbstractNowadays, despite centuries of striving for equality, women still face higher levels of discrimination compared to men in nearly every aspect of life. Recently, this systemic inequality has manifested in cyberspace through the proliferation of abusive content that is even more aggressive than what one would expect in the 21st century. Various research disciplines are now attempting to characterise this new manifestation of misogyny. The endeavour to comprehend this phenomenon has resulted in a significant increase in publications from several fields, including Social Sciences, Arts and Humanities, Psychology, and Computer Science. This paper presents a systematic review of multidisciplinary research on misogyny from the years 1990 to 2022, encompassing a total of 2830 articles retrieved from the Scopus database as of December 31, 2022. The literature is thoroughly analysed using three approaches: bibliometric analysis, topic detection, and qualitative analysis of the documents. The findings suggest that the analysis of online misogyny has been the primary driver behind the exponential growth in publications in this field. Additionally, the results of the topic analysis and topic interaction reveal a limited connection between the areas of knowledge that are necessary to fully grasp this complex phenomenon.