bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Rhombic 2D Conjugated Metal–Organic Framework as Cathode for High‐Performance Sodium‐Ion Battery
Authors: Qi Meiling , Cheng Linqi , Wang Heng‐Guo , Cui Fengchao , Yang Qingyuan , Chen Long 
Published: April 2024

Abstract2D conjugated metal–organic frameworks (2D c‐MOFs) have garnered significant attention as promising electroactive materials for energy storage. However, their further applications are hindered by low capacity, limited cycling life, and underutilization of the active sites. Herein, Cu‐TBA (TBA = octahydroxyltetrabenzoanthracene) with large conjugation units (narrow energy gap) and a unique rhombus topology is introduced as the cathode material for sodium‐ion batteries (SIBs). Notably, Cu‐TBA with a rhombus topology exhibits a high specific surface area (613 m2 g−1) and metallic band structure. Additionally, Cu‐TBA outperforms its hexagonal counterpart, Cu‐HHTP (HHTP = 2,3,6,7,10,11‐hexahydroxyltriphenylene), demonstrating superior reversible capacity (153.6 mAh g−1 at 50 mA g−1) and outstanding cyclability with minimal capacity decay even after 3000 cycles at 1 A g−1. This work elucidates a new strategy to enhance the electrochemical performance of 2D c‐MOFs cathode materials by narrowing the energy gap of organic linkers, effectively expanding the utilization of 2D c‐MOFs for SIBs.
Elucidation of Spatial Cooperativity in Chemo‐Immunotherapy by a Sequential Dual‐pH‐Responsive Drug Delivery System
Authors: Wang Shihao , Liu Lifeng , Tian Limin , Xu Pengcheng , Li Shixuan , Hu Lixin , Xia Yanming , Ding Yang , Wang Jian , Li Suxin 
Published: April 2024

AbstractCombining immune checkpoint blockade with chemotherapy through nanotechnology is promising in terms of safety and efficacy. However, the distinct subcellular distribution of each ingredient's action site makes it challenging to acquire an optimal synergism. Herein, a dual‐pH responsive hybrid polymeric micelle system, HNP(αPDL16.9, Dox5.3), is constructed as a proof‐of‐concept for the spatial cooperativity in chemo‐immunotherapy. HNP retains the inherent pH‐transition of each polymer, with stepwise disassembly under discrete pH thresholds. Within weakly acidic extracellular tumor environment, αPDL1 is first released to block the checkpoint on cell membranes. The remaining intact Doxorubicin‐loaded micelle NP(Dox)5.3 displays significant tropism toward tumor cells and releases Dox upon lysosomal pH for efficient tumor immunogenic cell death without immune toxicity. This sequential‐released pattern boosts DC activation and primes CD8+ T cells, leading to enhanced therapeutic performance than single agent or an inverse‐ordered combination in multiple murine tumor models. Using HNP, the indispensable role of conventional type 1 DC (cDC1) is identified in chemo‐immunotherapy. A co‐signature of cDC1 and CD8 correlates with cancer patient survival after neoadjuvant Pembrolizumab plus chemotherapy in clinic. This study highlights spatial cooperativity of chemo‐ and immuno‐agents in immunoregulation and provides insights into the rational design of drug combination for future nanotherapeutics development.
Metal–Drug Coordination Nanoparticles and Hydrogels for Enhanced Delivery
Authors: Wong Ka‐Ying , Nie Zhenyu , Wong Man‐Sau , Wang Yang , Liu Juewen 
Published: April 2024

AbstractDrug delivery is a key component of nanomedicine, and conventional delivery relies on the adsorption or encapsulation of drug molecules to a nanomaterial. Many delivery vehicles contain metal ions, such as metal–organic frameworks, metal oxides, transition metal dichalcogenides, MXene, and noble metal nanoparticles. These materials have a high metal content and pose potential long‐term toxicity concerns leading to difficulties for clinical approval. In this review, recent developments are summarized in the use of drug molecules as ligands for metal coordination forming various nanomaterials and soft materials. In these cases, the drug‐to‐metal ratio is much higher than conventional adsorption‐based strategies. The drug molecules are divided into small‐molecule drugs, nucleic acids, and proteins. The formed hybrid materials mainly include nanoparticles and hydrogels, upon which targeting ligands can be grafted to improve efficacy and further decrease toxicity. The application of these materials for addressing cancer, viral infection, bacterial infection inflammatory bowel disease, and bone diseases is reviewed. In the end, some future directions are discussed from fundamental research, materials science, and medicine.
Formation of Highly Tunable Periodic Plasmonic Structures on Gold Films Using Direct Laser Writing
Authors: Vilkevičius Kernius , Tsibidis George D. , Selskis Algirdas , Stratakis Emmanuel , Stankevičius Evaldas 
Published: April 2024

AbstractDirect laser writing method is a promising technique for the large‐scale and cost‐effective fabrication of periodic nanostructure arrays exciting hybrid lattice plasmons. This type of electromagnetic mode manifests a narrow and deep resonance peak with a high dispersion whose precise controllability is crucial for practical applications in photonic devices. Here, the formation of differently shaped gold nanostructures using the direct laser writing method on Au layers of different thicknesses is presented. The resonance peak is demonstrated to be highly dependent on the shape of the structures in the array, thus its position in the spectra, as well as the quality, can be additionally modulated by changing the morphology. The shape of the structure and the resonance itself pertain not only on the laser pulse energy but also on the grating period. This overlapping effect occurring at distances smaller than the diameter of the focused laser beam is studied in detail. By taking advantage of the highly controllable plasmonic resonance, the fabricated gratings open up new opportunities for applications in sensing.
Tumor Biomechanics Alters Metastatic Dissemination of Triple Negative Breast Cancer via Rewiring Fatty Acid Metabolism
Authors: Filipe Elysse C. , Velayuthar Sipiththa , Philp Ashleigh , Nobis Max , Latham Sharissa L. , Parker Amelia L. , Murphy Kendelle J. , Wyllie Kaitlin , Major Gretel S. , Contreras Osvaldo , Mok Ellie T. Y. , Enriquez Ronaldo F. , McGowan Suzanne , Feher Kristen , Quek Lake‐Ee , Hancock Sarah E. , Yam Michelle , Tran Emmi , Setargew Yordanos F. I. , Skhinas Joanna N. , Chitty Jessica L. , Phimmachanh Monica , Han Jeremy Z. R. , Cadell Antonia L. , Papanicolaou Michael , Mahmodi Hadi , Kiedik Beata , Junankar Simon , Ross Samuel E. , Lam Natasha , Coulson Rhiannon , Yang Jessica , Zaratzian Anaiis , Da Silva Andrew M. , Tayao Michael , Chin Ian L. , Cazet Aurélie , Kansara Maya , Segara Davendra , Parker Andrew , Hoy Andrew J. , Harvey Richard P. , Bogdanovic Ozren , Timpson Paul , Croucher David R. , Lim Elgene , Swarbrick Alexander , Holst Jeff , Turner Nigel , Choi Yu Suk , Kabakova Irina V. , Philp Andrew , Cox Thomas R. 
Published: April 2024

AbstractIn recent decades, the role of tumor biomechanics on cancer cell behavior at the primary site has been increasingly appreciated. However, the effect of primary tumor biomechanics on the latter stages of the metastatic cascade, such as metastatic seeding of secondary sites and outgrowth remains underappreciated. This work sought to address this in the context of triple negative breast cancer (TNBC), a cancer type known to aggressively disseminate at all stages of disease progression. Using mechanically tuneable model systems, mimicking the range of stiffness's typically found within breast tumors, it is found that, contrary to expectations, cancer cells exposed to softer microenvironments are more able to colonize secondary tissues. It is shown that heightened cell survival is driven by enhanced metabolism of fatty acids within TNBC cells exposed to softer microenvironments. It is demonstrated that uncoupling cellular mechanosensing through integrin β1 blocking antibody effectively causes stiff primed TNBC cells to behave like their soft counterparts, both in vitro and in vivo. This work is the first to show that softer tumor microenvironments may be contributing to changes in disease outcome by imprinting on TNBC cells a greater metabolic flexibility and conferring discrete cell survival advantages.
Spermidine‐Functionalized Injectable Hydrogel Reduces Inflammation and Enhances Healing of Acute and Diabetic Wounds In Situ
Authors: Wu Qianqian , Yang Runjiao , Fan Wenxuan , Wang Li , Zhan Jing , Cao Tingting , Liu Qiming , Piao Xianshu , Zhong Yinghui , Zhao Wenxian , Zhang Shuhan , Yu Jiaao , Liang Song , Roberts Thomas M. , Wang Bingdi , Liu Zhenning 
Published: April 2024

AbstractThe inflammatory response is a key factor affecting tissue regeneration. Inspired by the immunomodulatory role of spermidine, an injectable double network hydrogel functionalized with spermidine (DN‐SPD) is developed, where the first and second networks are formed by dynamic imine bonds and non‐dynamic photo‐crosslinked bonds respectively. The single network hydrogel before photo‐crosslinking exhibits excellent injectability and thus can be printed and photo‐crosslinked in situ to form double network hydrogels. DN‐SPD hydrogel has demonstrated desirable mechanical properties and tissue adhesion. More importantly, an “operando” comparison of hydrogels loaded with spermidine or diethylenetriamine (DETA), a sham molecule resembling spermidine, has shown similar physical properties, but quite different biological functions. Specifically, the outcomes of 3 sets of in vivo animal experiments demonstrate that DN‐SPD hydrogel can not only reduce inflammation caused by implanted exogenous biomaterials and reactive oxygen species but also promote the polarization of macrophages toward regenerative M2 phenotype, in comparison with DN‐DETA hydrogel. Moreover, the immunoregulation by spermidine can also translate into faster and more natural healing of both acute wounds and diabetic wounds. Hence, the local administration of spermidine affords a simple but elegant approach to attenuate foreign body reactions induced by exogenous biomaterials to treat chronic refractory wounds.
Human MHC Class II and Invariant Chain Knock‐in Mice Mimic Rheumatoid Arthritis with Allele Restriction in Immune Response and Arthritis Association
Authors: Romero‐Castillo Laura , Li Taotao , Do Nhu‐Nguyen , Sareila Outi , Xu Bingze , Hennings Viktoria , Xu Zhongwei , Svensson Carolin , Oliveira‐Coelho Ana , Sener Zeynep , Urbonaviciute Vilma , Ekwall Olov , Burkhardt Harald , Holmdahl Rikard 
Published: April 2024

AbstractTransgenic mice expressing human major histocompatibility complex class II (MHCII) risk alleles are widely used in autoimmune disease research, but limitations arise due to non‐physiologic expression. To address this, physiologically relevant mouse models are established via knock‐in technology to explore the role of MHCII in diseases like rheumatoid arthritis. The gene sequences encoding the ectodomains are replaced with the human DRB1*04:01 and 04:02 alleles, DRA, and CD74 (invariant chain) in C57BL/6N mice. The collagen type II (Col2a1) gene is modified to mimic human COL2. Importantly, DRB1*04:01 knock‐in mice display physiologic expression of human MHCII also on thymic epithelial cells, in contrast to DRB1*04:01 transgenic mice. Humanization of the invariant chain enhances MHCII expression on thymic epithelial cells, increases mature B cell numbers in spleen, and improves antigen presentation. To validate its functionality, the collagen‐induced arthritis (CIA) model is used, where DRB1*04:01 expression led to a higher susceptibility to arthritis, as compared with mice expressing DRB1*04:02. In addition, the humanized T cell epitope on COL2 allows autoreactive T cell‐mediated arthritis development. In conclusion, the humanized knock‐in mouse faithfully expresses MHCII, confirming the DRB1*04:01 alleles role in rheumatoid arthritis and being also useful for studying MHCII‐associated diseases.
Swing Origami‐Structure‐Based Triboelectric Nanogenerator for Harvesting Blue Energy toward Marine Environmental Applications
Authors: Liu Weilong , Wang Xiutong , Yang Lihui , Wang Youqiang , Xu Hui , Sun Yanan , Nan Youbo , Sun Congtao , Zhou Hui , Huang Yanliang 
Published: April 2024

AbstractThe appearance of triboelectric nanogenerators (TENG) provides a promising energy technology for harvesting abundant water wave energy. Here, the design and fabrication of a swinging origami‐structured TENG (SO‐TENG) tailored specifically for water wave energy harvesting are presented. The design incorporates an oscillating structure weighted at the bottom, inducing reciprocating motion propelled by the inertia of passing water waves. This reciprocating motion efficiently converts mechanical into electrical energy through the origami structure. By employing origami as the monomer structure, the surface contact area between friction layers is enhanced, thereby optimizing output performance. the swinging structure, combined with the placement of heavy objects, enhances the folding and contact of the origami, allowing it to operate effectively in low‐frequency water wave environments. This configuration exhibits robust power generation capabilities, making it suitable for powering small electronic devices in water wave environments. Furthermore, when applied to metal corrosion protection, the SO‐TENG demonstrates notable efficacy. Compared to exposed Q235 carbon steel, Q235 carbon steel protected by SO‐TENG exhibits a significant reduction in open‐circuit potential drop, approximately 155 mV, indicative of superior anti‐corrosion properties. It lays a solid foundation for water wave energy collection and self‐powered metal corrosion protection in marine environments.
Managing risk in commodity processing using formula pricing contracts: An application to ethanol
Authors: Bullock David W. , Wilson William W. 
Published: April 2024

AbstractAs is the case with many commodity processors, manufacturers of ethanol face considerable margin risk from a wide range of input and output prices and the interrelation of these risks with the technical operational efficiency of the plant. Buyers of ethanol desire greater budget certainty for future ethanol purchases. An approach to pricing that has found considerable use in the livestock, dairy, and milling industries is the use of component‐based formula pricing. This study constructs a Monte Carlo simulation model of a typical South Dakota ethanol plant that uses a formula contract to fix components of the ethanol price. The simulation results indicate that the contract has considerable margin risk management benefits for the ethanol producer. The buyer also achieves marginal risk management benefits but with greater budget certainty as the components are fixed. Additional observations of interest to the industry are drawn from the sensitivity results of the simulations. [EconLit Citations: Q13, G17].
Ultrabright NIR AIEgen nanoparticles‐enhanced lateral flow immunoassay platform for accurate diagnostics of complex samples
Authors: Shu Jia , Li Yujian , Cai Huan , Fu Qing , Li Chunyang , Yuan Jianbo , Zhao Yan , Liu Changjin , Wu Haiping , Ling Doudou , Liu Zhangluxi , Su Guannan , Cao Qingfeng , Huang Xiaolin , Chen Rui , Yang Peizeng 
Published: April 2024

AbstractAccurate and sensitive near‐infrared (NIR) luminescent lateral flow immunoassay (LFIA) has attracted considerable attention in the field of point‐of‐care testing (POCT). However, the detection accuracy and sensitivity are often compromised by the low fluorescence quantum efficiency (<10%) of the NIR fluorescent probe. Herein, ultrabright NIR AIEgen nanoparticles (PS@AIE830NPs) composed of polystyrene (PS) nanoparticles and NIR aggregation‐induced emission luminogen (AIEgen) with the maximum emission at 830 nm (AIE830) is reported, and its potential to promote an accurate and sensitive detection of complex samples by LFIA is described. The relative quantum yield (QY) of the PS@AIE830NPs was 14.76%, which was superior to that of the polymer embedding method and indocyanine green (ICG)‐based NIR nanoparticles. The PS@AIE830NPs immunolabeled‐LFIA combined with laboratory‐built NIR‐LFIA portable quantitative instruments (detected light range > 800 nm) completely eliminated background interference and allowed highly accurate and sensitive detection without any pre‐treatment steps. The limits of detection (LODs) for aflatoxin B1 (AFB1) in soy sauce, alpha hemolysin (Hla) of Staphylococcus aureus biomarker in joint fluid, and C‐reactive protein (CRP) in human haemolysed samples were 0.01 ng mL−1, 0.02 µg mL−1, and 0.156 mg L−1, respectively, commensurating with those of the corresponding gold standard assays and covering the detection range of interests. It is anticipated that the ultrabright NIR AIEgen nanoparticles will serve as a universally applicable signal probe for NIR‐LFIA diagnostics, promising to expand the range of applications for quantitative detection of complex samples.
Novel Alu insertion in the ZEB2 gene causing Mowat‐Wilson syndrome
Authors: Barington Maria , Bak Mads , Kjartansdóttir Kristín Rós , Hansen Thomas van Overeem , Birkedal Ulf , Østergaard Elsebet , Hove Hanne Buciek 
Published: April 2024

AbstractAlu elements are short, interspersed elements located throughout the genome, playing a role in human diversity, and occasionally causing genetic diseases. Here, we report a novel Alu insertion causing Mowat‐Wilson syndrome, a rare neurodevelopmental disorder, in an 8‐year‐old boy displaying the typical clinical features for Mowat‐Wilson syndrome. The variant was not initially detected in genome sequencing data, but through deep phenotyping, which pointed to only one plausible candidate gene, manual inspection of genome sequencing alignment data enabled us to identify a de novo heterozygous Alu insertion in exon 8 of the ZEB2 gene. Nanopore long‐read sequencing confirmed the Alu insertion, leading to the formation of a premature stop codon and likely haploinsufficiency of ZEB2. This underscores the importance of deep phenotyping and mobile element insertion analysis in uncovering genetic causes of monogenic disorders as these elements might be overlooked in standard next‐generation sequencing protocols.
“Why did I choose genetics?”: A survey of current and recent medical genetics and genomics residents provides insight into recruitment efforts
Authors: Hayek Jennifer Cassady , Blitzer Miriam G. , Robin Nathaniel H. 
Published: April 2024

AbstractThere is a shortage of clinical geneticists, even with concerted recruitment efforts. Previously, no data had been collected about why young career geneticists chose this specialty. To investigate this question, we carried out a survey of current and recent medical genetics and genomics residents. The goal of this survey was to understand their reasons for pursuing medical genetics and genomics as a specialty. Results demonstrate that, for most, interest in genetics begins in medical school and was largely influenced by mentorship. This suggests that placing greater focus on introducing medical genetics as a clinical specialty and fostering robust mentorship of students in preclinical years may increase recruitment into medical genetics residencies.
Neuropathologic changes at age 90+ related to sleep duration 19 to 40 years earlier: The 90+ Study
Authors: Melikyan Zarui A. , Kawas Claudia H. , Paganini‐Hill Annlia , Jiang Luohua , Bukhari Syed , Montine Thomas J. , Mander Bryce A. , Corrada María M. 
Published: April 2024

AbstractINTRODUCTIONWe investigated the association between sleep duration and neuropathologic changes 19 to 40 years later in oldest‐old (age 90+) participants of The 90+ Study.METHODSParticipants self‐reported sleep duration and underwent neuropathologic evaluation. We categorized sleep duration as < 7, 7 to 8 = reference, > 8 hours and dichotomized neuropathologic changes as present/absent. We estimated odds ratio (OR) and 95% confidence intervals (CI) using logistic regression.RESULTSIn 264 participants, mean age at sleep self‐report was 69 years, mean age at autopsy was 98 years, and mean interval between sleep self‐report and autopsy was 29 years (range: 19–40). Those reporting > 8 hours of sleep had lower likelihood of limbic‐predominant age‐related TDP‐43 encephalopathy neuropathologic change (LATE‐NC) inclusions (OR = 0.18; CI = 0.04–0.82) and amyloid beta deposits (OR = 0.34; 95% CI = 0.12–0.94).DISCUSSIONLong self‐reported sleep is associated with lower odds of neurodegenerative neuropathologic changes 19 to 40 years later in the oldest‐old, suggesting a potential role of sleep in accumulation of dementia‐related neuropathologies.Highlights
Association of self‐reported sleep with non‐Alzheimer's disease neuropathologic changes has not been explored.
Whether sleep duration is related to dementia neuropathologic changes decades later is unclear.
Long self‐reported sleep is associated with lower odds of Alzheimer's disease neuropathologic change 19 to 40 years later in the oldest‐old.
Long self‐reported sleep is associated with lower odds of limbic‐predominant age‐related TDP‐43 encephalopathy neuropathologic change 19 to 40 years later in the oldest‐old.
In Situ Formation of Platinum‐Carbon Catalysts in Propane Dehydrogenation
Authors: Nerl Hannah C. , Plodinec Milivoj , Götsch Thomas , Skorupska Katarzyna , Schlögl Robert , Jones Travis E. , Lunkenbein Thomas 
Published: April 2024

AbstractThe catalytic production of propylene via propane dehydrogenation (PDH) is a key reaction in the chemical industry. By combining operando transmission electron microscopy with density functional theory analysis, we show that the intercalation and ordering of carbon on Pt interstitials to form Pt−C solid solutions is relevant for increasing propylene production. More specifically, we found that at the point of enhanced propylene formation, the structure of platinum nanoparticles is transformed into a transient caesium chloride‐type Pt−C polymorph. At more elevated temperatures, the zincblende and rock salt polymorphs seemingly coexist. When propylene production was highest, multiple crystal structures consisting of Pt and carbon were occasionally found to coexist in one individual nanoparticle, distorting the Pt lattice. Catalyst coking was detected at all stages of the reaction, but did initially not affect all particles. These findings could lead to the development of novel synthesis strategies towards tailoring highly efficient PDH catalysts.
Organic Donor–Acceptor Thermally Activated Delayed Fluorescence Photocatalysts in the Photoinduced Dehalogenation of Aryl Halides
Authors: Bryden Megan Amy , Crovini Ettore , Comerford Thomas , Studer Armido , Zysman‐Colman Eli 
Published: April 2024

AbstractWe report a family of donor‐acceptor thermally activated delayed fluorescent (TADF) compounds based on derivatives of DMAC‐TRZ, that are strongly photoreducing. Both Eox and thus E*ox could be tuned via substitution of the DMAC donor with a Hammett series of p‐substituted phenyl moieties while Ered remained effectively constant. These compounds were assessed in the photoinduced dehalogenation of aryl halides, and analogues bearing electron withdrawing groups were found to produce the highest yields. Substrates of up to Ered=−2.72 V could be dehalogenated at low PC loading (1 mol %) and under air, conditions much milder than previously reported for this reaction. Spectroscopic and chemical studies demonstrate that all PCs, including literature reference PCs, photodegrade, and that it is these photodegradation products that are responsible for the reactivity.