bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tackling the social marketing formative research bottleneck: comparative analysis of the complementary nature of community-generated personas and focus groups
Authors: Khaliq Mahmooda , Wimbish Dove , Makris Angela 
Published: April 2024

Purpose
This study aims to understand the utility of personas and illustrate, through a case study, how a persona-building exercise in a Community Based Prevention Marketing (CBPM) training of community leaders elicited important insights that complemented findings from ongoing formative research on vaccine hesitancy in the Hispanic/Latino population in the USA during COVID-19 pandemic.

Design/methodology/approach
An exploratory concurrent parallel qualitative study design compared three personas created by community-based organization members (n = 37) to transcripts from five formative research focus groups (n = 30) from the same project. All participants in this study were recruited by the National COVID-19 Resiliency Network as part of their capacity-building and formative research activities. Grounded theory guided the content analysis.

Findings
This study found personas and focus groups to be complementary. A high degree of co-occurrence was observed when investigating the uptake of the COVID-19 vaccine under the categories of barriers, culture and communication. Between the two methods, the authors found strong associations between fear, disruption to the value system, work-related barriers, inaccessibility to health care and information sources and misinformation. Areas of divergence were negligible.

Research limitations/implications
While personas provided background information about the population and sharing “how” to reach the priority population, focus groups provided the “why” behind the behavior, followed by “how”.

Practical implications
A community-driven persona-building process built on cultural community knowledge and existing data can build community capacity, provide rich information to assist in the creation of tailored messages, strategies and overall interventions during a public health crisis and provide user-centered, evidence-based information about a priority population while researchers and practitioners wait on the results from formative research.

Originality/value
This case study provided a unique opportunity to analyze the complementary effectiveness of two methods acting in tandem to understand the priority population: stakeholder-informed persona-building and participant-informed focus group interviews. Understanding their complementary nature addresses a time gap that often exists between researchers and practitioners during times of crises and builds on recommendations associated with bringing rigor into practice, promoting academic contribution to real-world issues and building collaborative partnerships. Finally, it supports the utility of a nimble tool that improves social marketers’ ability to know more about their audience for intervention design when time is of the essence and formative research is ongoing.
Comparing three contract types to optimize profits in service firm – digital service platform relationships
Authors: Tarpey Richard , Yue Jinfeng , Zha Yong , Zhang Jiahong 
Published: April 2024

PurposeThe importance of service firms cooperating with digital platforms is widely acknowledged. The authors study three contractual relationships (fixed-cost, cost-sharing, and profit-sharing) between service firms (specifically hotels) and digital platforms in a highly fragmented service supply chain to examine which of these contract types optimizes profits.Design/methodology/approachThe authors extend prior models analyzing the optimal expected total profit from the travel service firm (hotel)–digital platform relationship, providing new insights into each contract type’s ability to coordinate decentralized systems and optimize profits for both parties.FindingsThis study finds that fixed cost contracts cannot coordinate the decentralized system. Cost-sharing contracts can coordinate the decentralized system but only allow one channel profit split. In contrast, profit-sharing contracts may not always perfectly coordinate the decentralized system but support alternative profit allocations. Practically, both profit-sharing and cost-sharing contracts are preferable to fixed-cost contracts.Practical implicationsThe paper includes implications for travel service firm managers to consider when structuring contracts with digital platforms to focus on profit optimization. Profit-sharing contracts are most preferable when cost and revenue data are fully shared between parties, while cost-sharing contracts are preferable over fixed-cost contracts.Originality/valueThis study extends prior investigations into the utility of different contract types on the optimal profit of a travel service firm (hotel)-digital platform provider relationship. The research fills a gap in the literature concerning the contracts used in these relationship types.
The relationship between the behavioral integrity and organizational commitment the mediating effects of the job satisfaction and psychological safety
Authors: Yang Feng-Hua , Chang Chen-Chieh , Pan Zhao-Cheng 
Published: April 2024

Purpose
This study aims to apply the affective events theory and psychological contract theory to investigate how job satisfaction and psychological safety mediate the effect of the behavioral integrity of supervisors on the organizational commitment of employees.

Design/methodology/approach
A questionnaire survey was conducted using purposive sampling. In total, 500 questionnaire copies were distributed, and 453 responses were collected, of which 441 were valid (valid response rate = 88.2%).

Findings
The behavioral integrity of supervisors has a direct negative effect on organizational commitment but significant positive effects on job satisfaction and psychological safety, and job satisfaction and psychological safety have significant positive effects on organizational commitment. Job satisfaction and psychological safety have significant mediating effects on the association between the behavioral integrity of supervisors and the organizational commitment of employees.

Practical implications
Leaders and top management should “practice what they preach,” integrate honesty into organizational culture through training and establish a code of conduct to ensure that employees uphold their commitments. Companies should establish appropriate disciplinary systems and norms related to work and other aspects of organizational culture; they should also establish fair, just and open assessment systems to minimize the gap between their employees’ actual and expected earnings.

Originality/value
This study is the first to simultaneously consider the mediating effects of job satisfaction and psychological safety on the association between behavioral integrity and organizational commitment.
Drug recognition experts in trials: perspectives from criminal justice system actors
Authors: Solensten Brittany , Willits Dale 
Published: April 2024

PurposeThe purpose of this study was to fill the gap in understanding the impact of Drug Recognition Expert (DRE) evidence and testimony in driving under the influence (DUI) trials. This was accomplished by documenting and analyzing the perceptions of DREs and the DRE program across different stakeholders to understand how and when this type of evidence is used in DUI trials.Design/methodology/approachThe methodology is a qualitative case study of the DRE program in one police agency in Washington. Data were collected using semi-structured interviews with criminal justice actors and state-level experts on their perceptions of the DRE program for the agency. Themes were developed from these interviews to analyze their perceptions of the efficacy and utility of DREs in trials.FindingsWhile the courts in Washington accept DRE evidence in criminal trials, DRE evidence is largely absent in the adjudication process. Participants noted multiple reasons for this, including the lack of trials, the primacy of blood evidence and the expansion of the Advanced Roadside Impaired Driving Enforcement (ARIDE) program.Originality/valueAlthough the DRE program has been around for decades, there is a lack of peer-reviewed studies regarding DRE evidence, and no studies regarding how court actors perceive and use DRE evidence. Understanding when and how DRE evidence is utilized in DUI trials can increase its value and utility by prosecutors and the national DRE program.
Investigation of process parameters for eco-friendly indigo dyeing of cotton fabric with reducing sugars
Authors: Mohtashim Quratulain , Farooq Salma , Asim Fareha 
Published: April 2024

Purpose
The application of indigo dyes in the denim industries has been criticised due to the introduction of non-renewable oxidation products into the environment. Previous studies have investigated that reducing sugars can be used as green alternatives to sodium dithionite in the indigo dyeing of cotton fabric owing to their reduced and stable redox potential in the dye bath. The purpose of this study was to dye denim cotton fabric with indigo dye using various reducing sugars and alkalis. The use of sucrose and potassium hydroxide (KOH) for indigo dyeing has been explored for the first time.

Design/methodology/approach
A mixed factorial design with four variables including alkali, pH, number of dips and type of reducing sugar at different levels was studied to identify a significant correlation between the effect of these variables on the colour strength and fastness properties of the dyeings.

Findings
Investigations were made to examine the significant factors and interactions of the selected responses in the eco-friendly dyeing method. This process has the potential to reduce the load of sulphite and sulphate generated in the dyebath due to the use of a conventional reducing agent, sodium dithionite. The colour strength of the dyeing reduced with fructose was found to be better than other reducing sugars and significantly influenced by the number of dips, pH levels and the interaction between pH and reducing sugars. Using fructose for indigo dyeing with two dips at a pH of 11.5, using KOH as an alkali, results in higher colour strength values. The fastness properties of the indigo-dyed sample with reducing sugars ranging from fair to good or good to excellent. Specifically, colour change receives a rating of grey scale 3–4, staining 4–5, dry rubbing 4 and light fastness 3–4. These assessments hold true across various factors such as the type of reducing sugar, alkali, pH and the number of dips. The optimised parameters leading to improved colour strength and fastness properties are also discussed.

Originality/value
This dyeing technique is novel and a green alternative to dithionite denim dyeing. This process is found to be useful for indigo dyeing of denim fabric leading to reduced and stable redox potential in the dyebath and acceptable colour strength of the dyed fabric.
Dilemmas in Regulation
Authors: Butlin Matthew , Findlay Christopher 
Published: April 2024

AbstractFour topics related to the operation of regulatory systems are considered. These concern the matters of dealing with globally sub‐optimal decisions made by regulators, the problem of specifying boundaries between groups of regulated entities in the application of regulation, dealing with a situation in which there are multiple regulators, and the alignment of regulation across jurisdictional borders. It is argued that current responses to these dilemmas tend to add to levels of inefficiency in the economy, with consequences for growth. Options for resolving them are considered, including new approaches to the design of regulation.
Subject‐Object Asymmetries and the Development of Relative Clauses between Late Middle English and Early Modern English
Authors: Bacskai‐Atkari Julia 
Published: April 2024

AbstractThis paper presents the results of a corpus study on the Wycliffe Bible and the King James Bible, examining the distribution of the pronouns who(m)/which and the complementiser that in relative clauses with a personal referent. The data indicate that the decisive factor in both periods was the function of the gap (subject vs. non‐subject): wh‐pronouns are preferred in object relative clauses, while that is preferred in subject relative clauses. In addition, the paper argues that the subject/non‐subject distinction was decisive not only regarding the major wh/that distribution but also regarding the who(m)/which distinction. While in the case of the wh/that distinction, a syntactic difference (relative pronoun versus relative complementiser) underlies the attested asymmetry, the pronouns who(m) and which do not differ in their core syntactic properties. The data clearly indicate that both the wh‐strategy in general and the pronoun who(m) in particular started to spread from the lower functions of the Noun Phrase Accessibility Hierarchy, whereby the spread of who(m) was one step behind the general spread of the wh‐strategy. The findings thus suggest that asymmetries along the lines of the Noun Phrase Accessibility Hierarchy are not necessarily paired up with syntactic asymmetries.
Prognostic impact of prostate‐specific membrane antigen positron emission tomography (PSMA PET) staging for clinically node‐positive prostate cancer
Authors: Leow Boon Yang Jerome , Eade Thomas , Hruby George , Lieng Hester , Hsiao Edward , Brown Chris , Kneebone Andrew 
Published: April 2024

AbstractIntroductionIn the current American Joint Committee on Cancer staging system, patients with pelvic nodal metastases are considered stage IV prostate cancer. This study aims to investigate whether men with prostate‐specific membrane antigen positron emission tomography (PSMA PET)‐detected pelvic node‐positive prostate cancer at diagnosis have a better outcome compared to men with node‐positive disease identified on conventional imaging.MethodsThis is a retrospective cohort study comparing the outcomes of men with node‐positive prostate cancer and disease confined to the pelvis, staged with conventional versus PSMA PET imaging. Men had to be treated definitively with a combination of androgen deprivation therapy and radiation treatment to the prostate and pelvic lymph nodes. Kaplan–Meier and Cox regression analysis was used to compare biochemical failure‐free survival (BFFS) and overall survival (OS).ResultsSeventy‐six men with nodal metastases confined to the pelvis were identified. Fifty‐one were detected with PSMA PET while 25 were staged with conventional imaging. PSMA PET staged patients had a lower proportion of Gleason 8–10 disease (78% vs. 96%) as well as a lower median prostate‐specific antigen (11 ng/mL vs. 26 ng/mL). BFFS at 4 years was 72% with PSMA PET‐detected node‐positive disease vs. 38% with conventionally detected node‐positive disease. Four‐year OS was 93% with PSMA PET staged patients vs. 76% with conventionally staged patients. On multivariate analysis, the PSMA PET staged group was associated with improved BFFS (Adjusted HR = 3.00, 95% CI 1.43, 6.29, P = 0.004) and OS (Adjusted HR = 5.81, 95% CI 1.43, 23.7, P = 0.007).ConclusionMen with PSMA PET‐detected node‐positive prostate cancer confined to the pelvis have significantly better biochemical control and survival compared to those with node‐positive pelvic disease identified through conventional staging.
Contrasting late season pest insect abundance in non‐crop vegetation areas and nearby canola fields in the Canadian Prairies
Authors: Innes Rebecca , Neame Tobyn , Galpern Paul 
Published: April 2024

Abstract
Non‐crop vegetation areas in agricultural landscapes are vital for maintaining biodiversity. However, they potentially host pest insects, which can cause economic loss in crop fields.
Some insect species have been found to spill into crops from these areas, but this varies depending on species, landscape composition and the time of the season.
To determine if five common pest insects of canola crops were spilling into fields during the late growing season, we collected samples at various distances from non‐crop areas, in a part of the Canadian Prairies (Alberta, Canada) where this crop is widely grown.
Sampling occurred at 15 sites in each of 10 fields (N = 150 sites). We modelled changes in pest abundance over distance from the non‐crop areas and contrasted the abundance of each taxon in the crop and non‐crop areas.
Only leafhoppers (Hemiptera: Cicadellidae) demonstrated a declining gradient in abundance that is consistent with spillover from non‐crop vegetation areas into the canola fields. Weevils were found to have significantly higher abundance in the non‐crop areas, indicating a relationship between this taxon and the non‐crop area in the late season, but there was no decline in abundance, which might indicate spillover occurring. All taxa demonstrated spatial differences in abundance among fields.
This study found limited evidence that the pests are spilling over from non‐crop vegetation into canola crops during the late season. Therefore, movement of pests from non‐crop vegetation areas at this time is unlikely to be a driver of pest pressure for this economically important crop.
Time trend analysis of rare cancer incidence 2011–2018: Nationwide population‐based cancer registries in Japan
Authors: Sugiyama Hiromi , Konda Manami , Saika Kumiko , Matsuda Tomohiro 
Published: April 2024

AbstractRare cancers collectively account for a significant proportion of the overall cancer burden in Japan. We aimed to describe and examine the incidence of each rare cancer and the temporal changes using the internationally agreed rare cancer classification. Cancer cases registered in regional population‐based cancer registries from 2011 to 2015 and the National Cancer Registry (NCR) from 2016 to 2018 were classified into 18 families, 68 Tier‐1 cancer groupings, and 216 single cancer entities based on the RARECAREnet list. Crude incidence rates and age‐standardized incidence rates (ASR) were calculated for Tier‐1 and Tier‐2 cancers. The annual percent change and the 95% and 99% confidence limits for annual ASR for each of the 68 Tier‐1 cancers were estimated using the log‐linear regression of the weighted least squares method. The differences in ASRs between 2011 and 2018 were evaluated as an absolute change. A total of 5,640,879 cases were classified into Tier‐1 and Tier‐2 cancers. The ASRs of 18 out of 52 Tier‐1 cancers in the rare cancer families increased, whereas the ASR for epithelial tumors of gallbladder decreased. The ASRs of 6 out of the 16 Tier‐1 cancers in the common cancer families increased, whereas those of epithelial tumors of stomach and liver decreased. There was no significant change in the incidence of the other 40 Tier‐1 cancers. The incidence of several cancers increased due to the dissemination of diagnostic concepts, improved diagnostic techniques, changes in coding practice, and the initiation of the NCR.
Pyroptotic macrophages promote proliferation and chemotherapy resistance of peripheral T‐cell lymphoma via TLR4 signaling pathway
Authors: Zhang Han , Li Liru , Zhang Zijian , Gao Shiqi , Yang Mingzhe , Ma Wenjie , Li Hongbin , Zhao Wenhui , Yang Huike , Zhang Yue , Zhao Shu 
Published: April 2024

AbstractPeripheral T‐cell lymphoma (PTCL) is a highly aggressive type of non‐Hodgkin's lymphoma with a poor prognosis. Pyroptosis is a newly discovered procedural cell death mode, which has been implicated to occur in both tumor cells and immune cells. However, the occurrence and effect of pyroptosis on PTCL remain unclear. Here, we found that pyroptosis occurred in interstitial macrophages of PTCL rather than in tumor cells. In clinical specimens, macrophage pyroptosis was associated with a poor prognosis of PTCL. In vitro experiments and gene sequencing results showed that pyroptotic macrophages could upregulate the expression of TLR4 through secreting inflammatory cytokines IL‐18. Upregulated TLR4 activated its downstream NF‐κB anti‐apoptotic signaling pathway, thus leading to malignant proliferation and chemotherapy resistance of tumor cells. Moreover, the expression of factors such as XIAP in the NF‐κB anti‐apoptotic pathway was downregulated after the knockdown of TLR4, and the malignant promotion effect of pyroptotic macrophages on PTCL cells was also reversed. Our findings revealed the mechanism of pyroptotic macrophages promoting the malignant biological behavior of PTCL and elucidated the key role of TLR4 in this process. In‐depth analysis of this mechanism will contribute to understanding the regulatory effect of PTCL by the tumor microenvironment and providing new ideas for the clinical treatment of PTCL.
Cytotoxic activity and cell specificity of a novel LHRH peptide drug conjugate, D‐Cys6‐LHRH vedotin, against ovarian cancer cell lines
Authors: Vankadara Subramanyam , Ke Zhiyuan , Wang Sifang , Foo Sin Yun , Gunaratne Jayantha , Lee May Ann , Koh Xiaoying , Chia C. S. Brian 
Published: April 2024

AbstractOvarian cancer is the most deadly female gynaecological malignancy in developed countries and new treatments are urgently needed. The luteinising hormone releasing hormone (LHRH) peptide drug conjugate Zoptarelin doxorubicin is one such potential new drug modality that entered clinical trials for treating LHRH receptor‐positive gynaecological cancers. However, development stopped after disappointing Phase 3 results in 2017. We believe the lack of efficacy was due to linker instability and payload potency. In this work, we replaced its linker‐toxin with vedotin (MC‐VC‐PABC‐MMAE), yielding the novel peptide drug conjugate D‐Cys6‐LHRH vedotin. A GI50 and cell specificity comparison against cancerous and non‐cancerous ovarian cell lines showed significantly superior bioactivity and selectivity over Zoptarelin doxorubicin (GI50 4 vs. 453 nM) and other chemotherapeutic drugs used for treating ovarian cancers. Our results suggest D‐Cys6‐LHRH vedotin can potentially be used as a treatment for ovarian cancer.
Comparative study of imaging and pathology of primary mucinous adenocarcinoma with different imaging manifestations
Authors: Han Jun , Gao Jie , Chen Demei , Du Mou , Wu Yuxin , Ma Xidong , Xie Mei , Han Hua , Wu Chongchong , Xue Xinying 
Published: April 2024

AbstractBackgroundPulmonary mucinous adenocarcinoma is a special type of lung cancer. Its imaging manifestations are diverse, which brings challenges to clinical diagnosis. However, its formation mechanism is unclear.ObjectiveThe objective of this study is to analyse the relevant mechanisms of the formation of pulmonary mucinous adenocarcinoma by observing its different imaging and pathological manifestations.Data and methodsRetrospective analysis was conducted on imaging manifestations and pathological data of 103 patients with pulmonary mucinous adenocarcinoma confirmed intraoperatively or pathologically.ResultsForty‐three patients had pulmonary mucinous adenocarcinoma with a solitary nodule/mass, 41 patients with localized pneumonia and 19 patients with diffuse pneumonia. Their CT manifestations included ‘falling snowflake sign’, ground‐glass opacity close to the heart, vacuous signs/honeycombing and withered tree branches. Under the microscope, all the three types of pulmonary mucinous adenocarcinoma had visibly formed mucus lakes but were made of tumour cells with totally different shapes, which included the goblet‐like shape (tall column‐like shape) and quasi‐circular shape. Tall column‐shaped tumour cells were negative or weakly positive for thyroid transcription factor‐1 (TTF‐1) and strongly positive for ALK mutation, whereas quasi‐circular tumour cells were positive for TTF‐1 and less positive for ALK mutation.ConclusionThe different imaging manifestations of mucinous adenocarcinoma are possibly due to the different amounts or viscosity of mucus produced, and the mechanisms of its formation may include (1) tumour cells in different shapes have different abilities to produce mucus; (2) tumours in different stages produce different amounts or viscosity of mucus; and (3) the TTF‐1 and ALK genes affect the production of mucus.