bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pediatric diffuse large B‐cell lymphoma demonstrates a high proliferation index, frequent c‐Myc protein expression, and a high incidence of germinal center subtype: Report of the French–American–British (FAB) international study group
Authors: Miles Rodney R. , Raphael Martine , McCarthy Keith , Wotherspoon Andrew , Lones Mark A. , Terrier‐Lacombe Marie J. , Patte Catherine , Gerrard Mary , Auperin Anne , Sposto Richard , Davenport Virginia , Cairo Mitchell S. , Perkins Sherrie L. 
Published: May 2008

AbstractBackgroundDiffuse large B‐cell lymphoma (DLBCL) makes up 10–20% of pediatric non‐Hodgkin lymphoma, and these patients have a significantly better prognosis than adults with DLBCL. The difference in prognosis may be related to clinical, phenotypic, and/or biological differences between adult and pediatric DLBCL. In adult DLBCL, the germinal center (GC) phenotype is associated with a better prognosis than the activated B‐cell (ABC) phenotype. However, a high proliferative index and expression of Bcl2 and c‐Myc protein have all been associated with worse outcomes. While multiple studies have addressed the phenotype and expression patterns of adult DLBCL, relatively little is known about these biological variables in pediatric DLBCL. The goal of this study was to investigate the proliferative index, the relative frequencies of the GC and non‐GC subtypes, and the expression of Bcl2 and c‐Myc protein in a cohort of children with DLBCL treated in a uniform manner.ProcedureWe performed immunohistochemistry (IHC) for MIB1, CD10, Bcl6, MUM1, Bcl2, and c‐Myc on DLBCL tissue from children treated uniformly in the FAB LMB96 trial (SFOP LMB96/CCG5961/UKCCSG/NHL 9600).ResultsCompared to published adult DLBCL studies, pediatric DLBCL demonstrated moderate to high proliferation rates (83%), increased c‐Myc protein expression (84%), decreased Bcl2 protein expression (28%), and an increased frequency of the GC phenotype (75%).ConclusionsThese findings suggest that there are significant biologic differences between pediatric and adult forms of DLBCL, which may contribute to the superior prognosis seen in the pediatric population relative to adult disease. Pediatr Blood Cancer 2008;51:369–374. © 2008 Wiley‐Liss, Inc.
Captopril‐induced lichen planus pemphigoides
Authors: Ben Salem Chaker , Chenguel Lilia , Ghariani Najet , Denguezli Mohamed , Hmouda Houssem , Bouraoui Kamel 
Published: May 2008

AbstractPurposeTo report a rare case of lichen planus pemphigoides (LPP) possibly induced by captopril.Case summaryA 74‐year‐old woman developed pruriginous and bullous lichenoid eruption after starting captopril for hypertension. Histopathological and immunological features were consistent with the diagnosis of LPP that was managed by discontinuing captopril and corticosteroid therapy. Eight months after the cessation of oral steroid therapy, no relapse had occurred.DiscussionLPP, a rare skin disorder, has been generally considered to represent a mixture of clinical, histopathological and immunological patterns of lichen planus and bullous pemphigoid. It is predominantly idiopathic. However, in rare cases it has been associated with the administration of drugs. Here we present a typical LPP related to the use of captopril.ConclusionsClinicians should be aware of the ability of captopril to induce LPP. Copyright © 2008 John Wiley & Sons, Ltd.
Effects of the structures of polymerizable monomers on the electro‐optical properties of UV cured polymer dispersed liquid crystal films
Authors: Li Wenbo , Cao Yubo , Cao Hui , Kashima Miki , Kong Lingjie , Yang Huai 
Published: May 2008

AbstractPolymer dispersed liquid crystal (PDLC) films were prepared by photopolymerization of liquid crystal (LC)/polymerizable monomers/photoinitiator composites. The effects of the structures of the polymerizable monomers on the electro‐optical properties of PDLC films were investigated. It was found that the length of the molecular chain and the rigidity and flexibility of molecules influenced the structure of the polymer network in the PDLC films somewhat, and then affected the electro‐optical properties of the composites accordingly. © 2008 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 46: 1369–1375, 2008
Crystallization and morphology of poly(ethylene oxide‐b‐lactide) crystalline–crystalline diblock copolymers
Authors: Huang Shaoyong , Jiang Shichun , An Lijia , Chen Xuesi 
Published: May 2008

AbstractThe crystallization behaviors and morphology of asymmetric crystalline–crystalline diblock copolymers poly(ethylene oxide‐lactide) (PEO‐b‐PLLA) were investigated using differential scanning calorimetry (DSC), wide angle X‐ray diffraction (WAXD), and microscopic techniques (polarized optical microscopy (POM) and atomic force microscopy (AFM)). Both blocks of PEO5‐b‐PLLA16 can be crystallized, which was confirmed by WAXD, while PEO block in PEO5‐b‐PLLA30 is difficult to crystallize because of the confinement induced by the high glass transition temperature and crystallization of PLLA block with the microphase separation of the block copolymer. Comparing with the crystallization and morphology of PLLA homopolymer and differences between the two copolymers, we studied the influence of PEO block and microphase separation on the crystallization and morphology of PLLA block. The boundary temperature (Tb) was observed, which distinguishes the crystallization into high‐ and low‐temperature ranges, the growth rate and morphology were quite different between the ranges. Crystalline morphologies including banded spherulite, dendritic crystal, and dense branching in PEO5‐b‐PLLA16 copolymer were formed. The typical morphology of dendritic crystals including two different sectors were observed in PEO5‐b‐PLLA30 copolymer, which can be explained by secondary nucleation, chain growth direction, and phase separation between the two blocks during the crystallization process. Lozenge‐shaped crystals of PLLA with screw dislocation were also observed employing AFM, but the crystalline morphology of PEO block was not observed using microscopy techniques because of its small size. © 2008 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 46: 1400–1411, 2008
A compact spin‐free combinatoric open‐shell coupled cluster theory applied to single‐reference doublets
Authors: Datta Dipayan , Mukherjee Debashis 
Published: May 2008

AbstractIn this article, we present an explicitly spin‐free compact coupled cluster (CC) theory for simple open‐shell systems, e.g., doublets, biradicals, which can be described either by a single open‐shell determinant or by a configuration state function (CSF) which corresponds to a single spatial configuration but is a linear combination of determinants with different spin allocations. A new cluster expansion Ansatz for the wave‐operator is introduced, in which the spin‐free cluster operators are either of the form of closed‐shell‐like n hole‐n particle excitations or contain valence excitations, which may involve exchange spectator scatterings. These latter type of operators are allowed to contract among themselves through the spectator orbitals. The novelty of the Ansatz is in the choice of a suitable automorphic factor accompanying each composite of noncommuting operators, ensuring that each such composite appears only once. The resulting CC equations consist of two types of terms: one is direct and the other is folded and the latter involves the effective Hamiltonian operator. We emphasize that while the direct term terminates exactly at the quartic power of the cluster amplitudes, termination of the folded term is dictated by the valence rank of the effective Hamiltonian operator, just as in the spin‐free open‐shell CC theory with a normal ordered exponential Ansatz. Example applications are presented by computing the core and valence‐ionized state energies of H2O molecule and comparing the results with benchmark full CI results. The results show the efficacy of the method. © 2008 Wiley Periodicals, Inc. Int J Quantum Chem, 2008
Carbohydrate‐binding modules from family 11: Understanding the binding mode of polysaccharides
Authors: Brás N. F. , Cerqueira N. M. F. S. A. , Fernandes P. A. , Ramos M. J. 
Published: May 2008

AbstractThis article focuses on the molecular determinants that drive the binding and recognition of polysaccharides to the carbohydrate‐binding modules (CBMs) from family 11. The CBMs are noncatalytic modules of a high‐hierarchy multisubunit complex called cellulosome, which are known to be crucial for the efficient degradation of polysaccharides. Their function and behavior has not yet been fully clarified, and taking into account the bioeconomical interest in this subject it has become a challenging research problem. Our computational results point to the fact that the binding interface of the CBM11 can bind only one single polysaccharide chain, which is in agreement with other CBMs from type B. The central binding site has affinity for polysaccharides with more than four subunits, and there are four main residues that have a central role in this interaction: Asp99, Arg126, Asp128, and Asp146. Furthermore, there are three tyrosine residues, Tyr22, Tyr53, and Tyr129 that are crucial for the guiding and packing of the polysaccharide to the charged regions. In this article, we have also compared the structure of the CBM11 with other CBMs families from type B and found many similarities, which suggest similar binding activities and functions. © 2008 Wiley Periodicals, Inc. Int J Quantum Chem, 2008
Detection of carbonyl groups in triterpenoids by hydroxylamine hydrochloride derivatization using electrospray ionization mass spectrometry
Authors: Liu Xin , Zhou Yan , Chen Haibin , Peng Shulin , Gu Yucheng , Ding Lisheng 
Published: May 2008

AbstractA rapid, simple electrospray ionization mass spectrometry (ESI‐MS) sensitivity enhancement method for detecting carbonyl groups in triterpenoids has been developed by using hydroxylamine hydrochloride (NH2OH · HCl) as a derivatization reagent. We use the oxime formed during the derivatization reactions and its Beckmann rearrangement intermediates as a means of detecting the carbonyl groups originally present in these triterpenoids. In comparison with other derivatization methods reported in the literature, this method is simple, specific and can be used to detect carbonyl groups in triterpenoids which have low polarity and are poorly or non‐ionizable. Moreover, it can also be used to detect hydroxyl groups by using the Dess‐Martin periodinane (DMP) to convert primary and secondary hydroxyls into carbonyl groups. Copyright © 2008 John Wiley & Sons, Ltd.
Restrained ion population transfer: a novel ion transfer method for mass spectrometry
Authors: Kaiser Nathan K. , Skulason Gunnar E. , Weisbrod Chad R. , Wu Si , Zhang Kai , Prior David C. , Buschbach Michael A. , Anderson Gordon A. , Bruce James E. 
Published: May 2008

AbstractFourier transform ion cyclotron resonance (FTICR) mass spectrometers function such that the ion accumulation event takes place in a region of higher pressure outside the magnetic field which allows ions to be thermally cooled before being accelerated toward the ICR cell where they are decelerated and re‐trapped. This transfer process suffers from mass discrimination due to time‐of‐flight effects. Also, trapping ions with substantial axial kinetic energy can decrease the performance of the FTICR instrument compared with the analysis of thermally cooled ions located at the trap center. Therefore, it is desirable to limit the energy imparted to the ions which results in lower applied trap plate potentials and reduces the spread in axial kinetic energy. The approach presented here for ion transfer, called restrained ion population transfer or RIPT, is designed to provide complete axial and radial containment of an ion population throughout the entire transfer process from the accumulation region to the ICR cell, eliminating mass discrimination associated with time‐of‐flight separation. This was accomplished by use of a number of quadrupole segments arranged in series with independent control of the direct current (DC) bias voltage applied to each segment of the quadrupole ion guide. The DC bias voltage is applied in such a way as to minimize the energy imparted to the ions allowing transfer of ions with low kinetic energy from the ion accumulation region to the ICR cell. Initial FTICR mass spectral data are presented that illustrate the feasibility of RIPT. A larger m/z range for a mixture of peptides is demonstrated compared with gated trapping. The increase in ion transfer time (3 ms to 130 ms) resulted in an ∼11% decrease in the duty cycle; however this can be improved by simultaneously transferring multiple ion populations with RIPT. The technique was also modeled with SIMION 7.0 and simulation results that support our feasibility studies of the ion transfer process are presented. Copyright © 2008 John Wiley & Sons, Ltd.
Distributed Decision‐Tree Induction in Peer‐to‐Peer Systems
Authors: Bhaduri Kanishka , Wolff Ran , Giannella Chris , Kargupta Hillol 
Published: May 2008

AbstractThis paper offers a scalable and robust distributed algorithm for decision‐tree induction in large peer‐to‐peer (P2P) environments. Computing a decision tree in such large distributed systems using standard centralized algorithms can be very communication‐expensive and impractical because of the synchronization requirements. The problem becomes even more challenging in the distributed stream monitoring scenario where the decision tree needs to be updated in response to changes in the data distribution. This paper presents an alternate solution that works in a completely asynchronous manner in distributed environments and offers low communication overhead, a necessity for scalability. It also seamlessly handles changes in data and peer failures. The paper presents extensive experimental results to corroborate the theoretical claims. Copyright © 2008 Wiley Periodicals, Inc., A Wiley Company Statistical Analy Data Mining 1: 000‐000, 2008
Edmondson‐Steiner Grading Increases the Predictive Efficiency of TNM Staging for Long‐term Survival of Patients with Hepatocellular Carcinoma After Curative Resection
Authors: Zhou Li , Rui Jing‐An , Ye Da‐Xiong , Wang Shao‐Bin , Chen Shu‐Guang , Qu Qiang 
Published: May 2008

AbstractBackgroundThe 6th edition TNM staging (TNM‐6) for hepatocellular carcinoma (HCC) has been recommended. However, its superiority, in contrast to the previous 5th edition (TNM‐5), has not been fully recognized. Besides, tumor differentiation was not included. The current study was designed to compare the value of these two staging systems and, more importantly, to elucidate whether Edmondson‐Steiner grading, a well‐acknowledged histological classification, is helpful in further discriminating different prognosis of HCC.MethodsProspectively collected clinicopathological and follow‐up data of consecutive 171 patients with HCC undergoing curative hepatic resection (CHR) were reviewed retrospectively. The impacts of variables on survival were determined by univariate and multivariate statistical analyses.ResultsThe differences of survival between stages of the TNM‐6 and TNM‐5 were almost significant, except for disease‐free survival for TNM‐5. Moreover, TNM‐6 might be a more powerful prognostic predictor compared with TNM‐5, although their impacts on survival were all not independent, unlike Edmondson‐Steiner grading. For patients with each stage of TNM‐6, Edmondson‐Steiner grade was the sole significant variable in both univariate and multivariate analyses. Finally, a novel scoring criteria (prognostic scoring for CHR, PSCHR) integrating Edmondson‐Steiner grading and TNM‐6 was attempted and statistically shown to be of independent significance and stronger predicting value for prognosis of curatively resected HCC.ConclusionTNM‐6 revealed to be more significantly prognostic than TNM‐5 in patients with HCC after curative hepatic resection. Edmondson‐Steiner grading could raise the predictive efficiency of TNM‐6 for postresectional survival of patients with HCC. Therefore, PSCHR containing Edmondson‐Steiner grading was preliminarily proposed.
Fabrication and Properties of Porphyrin Nano- and Micro-particles with Novel Morphology
Authors: Li Xiangqing , Zhang Line , Mu Jin , Qiu Jinlong 
Published: May 2008

Abstract
New types of porphyrin nano- and micro-particles composed of J- and H-heteroaggregates were prepared by electrostatic self-assembly of two oppositely charged porphyrins, tetrakis(4-trimethylammoniophenyl)porphyrin (H2TAPP4+) and tetrakis(4-sulfonatophenyl)porphyrin cobalt(II) (CoTPPS4−), in aqueous solutions. Transmission electron microscopy (TEM) images showed novel morphology and size distribution of porphyrin particles fabricated under different experimental conditions. The assembly process of the nano- and micro-particles was monitored by UV–Vis spectra. Fluorescence spectra and UV–Vis spectra provided optical information on the formation of the nano- and micro-particles. Cyclic voltammograms of the porphyrin particles indicated that the electron gain and loss of the H2TAPP4+ion were restrained, and the electron transfer of the CoTPPS4−ion was promoted in the J- and H-type porphyrin heteroaggregates within the particles. The stability and constitution of the nano- and micro-particles were confirmed by UV-light irradiation, heat-treatment, and pH and ionic strength changes. Photoelectrochemical measurements showed that the photoelectron transfer of TiO2modified with the particles was more efficient than that of TiO2sensitized by either monomers. The photoelectronic and photocatalytic properties of the products indicated that the pyramidal or spherical configuration of the nano- and micro-particles was favorable for the absorption and transfer of the energy. It can be found that TiO2sensitized by the porphyrin nano- and micro-particles exhibits significant improvement in energy conversion and photocatalytic activity with reference to pure TiO2.
Human angiogenic cell precursors restore function in the infarcted rat heart: A comparison of cell delivery routes
Authors: Sun Zhuo , Wu Jun , Fujii Hiroko , Wu Jiang , Li Shu‐Hong , Porozov Svetlana , Belleli Adina , Fulga Valentin , Porat Yael , Li Ren‐Ke 
Published: May 2008

AbstractBackgroundWe recently isolated angiogenic cell precursors (ACPs) from human blood, which can induce angiogenesis in vitro.AimsIn the present study, we used a nude rat model of ischaemic cardiomyopathy to compare the efficacy of intramyocardial and intracoronary ACP implantation, and to evaluate effects on cardiac function, scar size and angiogenesis.Methods and resultsAdult nude rats underwent coronary artery ligation. Six days later, ACPs (characterized in vitro prior to implantation) or culture media were injected directly into the ischaemic myocardial region or into the coronary artery via the aorta. Cardiac function was measured by echocardiography prior to and at 2 and 4 weeks after implantation. Scar morphology, cell engraftment, and myocardial angiogenesis were evaluated at 4 weeks. Two and four weeks after implantation, cardiac function declined in both of the control groups but improved in both the intramyocardial and intracoronary ACP groups. Significant reductions in myocardial scar area were only observed in the intramyocardial ACP group, while increases in blood vessel density, which were observed in all ACP recipients, were greatest in the intracoronary ACP group.ConclusionsHuman ACPs, delivered via intramyocardial or intracoronary injection, engrafted into damaged cardiac tissue and improved cardiac function within 4 weeks through effects on scar morphology and blood vessel formation.
The wheat germ cell‐free based screening of protein substrates of calcium/calmodulin‐dependent protein kinase II delta
Authors: Masaoka Takashi , Nishi Mayuko , Ryo Akihide , Endo Yaeta , Sawasaki Tatsuya 
Published: May 2008

MINT‐6538664: CAMK2D (uniprotkb:Q13557) phosphorylates (MI:0217) STIP1 (uniprotkb:P31948) by protein kinase assay (MI:0424)
MINT‐6538652: CAMK2D (uniprotkb:Q13557) phosphorylates (MI:0217) EIF4B (uniprotkb:P23588) by protein kinase assay (MI:0424)
Effects of chronic proline administration on lipid contents of rat brain
Authors: Vianna Luciene P. , Delwing Daniela , Kurek Andréa G. , Breier Ana C. , Kreutz Fernando , Chiarani Fábria , Stefanello Francieli M. , Wyse Angela T.S. , Trindade Vera M. Treis 
Published: May 2008

AbstractIn the present work we investigated the effects of chronic proline administration on ganglioside, cholesterol and phospholipid total contents, as well as on ganglioside profile in cerebral cortex, hippocampus, hypothalamus and cerebellum of rats. We also evaluated the ganglioside content and profile in detergent‐soluble and resistant microdomains isolated from synaptic membranes obtained from cerebral cortex. Proline solution (hyperprolinemic) or saline (control) were subcutaneously administered to rats from 6th to 28th post‐natal day, according to body weight. Twelve hours after the last injection, the animals were sacrificed by decapitation without anaesthesia. Brain structures were homogenized with chloroform:methanol for lipid extraction. Synaptic membranes were obtained by differential centrifugation and detergent‐soluble and resistant microdomains were isolated by cold Triton X‐100 treatment. Results showed that rats subjected to chronic proline treatment presented a significant increase of ganglioside content in cortex and hippocampus, while this membrane lipid content was not altered in hypothalamus and cerebellum. Besides, phospholipid and cholesterol contents were not modified in all structures studied. On the other hand, ganglioside content decreased in detergent‐soluble and resistant microdomains isolated from synaptic membrane obtained from hyperprolinemic cortex. Although ganglioside profiles were apparently not modified, the individual absolute quantities were altered in cortex and hippocampus total lipid extract and membrane microdomains. Our findings suggest that chronic proline treatment affects in a distinct manner different cerebral regions concerning the lipid composition of the cell membranes, reflecting on its distribution in the cortex membrane microdomains. Among these phenomena consequences, distinct modulations in synaptic transmission may be suggested which might contribute to the impairment in cognition and/or other neurological dysfunctions found in hyperprolinemia type II patients.
AUTOMORPHISMS OF METABELIAN PRIME POWER ORDER GROUPS OF MAXIMAL CLASS
Authors: FOULADI S. , ORFI R. 
Published: May 2008

AbstractLetGbe ap-group of maximal class of orderpn. It is shown that the order of the group of all automorphisms ofGcentralizing the Frattini quotient takes the maximum valuep2n−4if and only ifGis metabelian. A structure theorem is proved for the Sylowp-subgroup,Autp(G), of the automorphism group ofGwhenGis metabelian. Forp=2,Aut2(G) is the full automorphism group ofG. Forp=3, we prove a structure theorem for the full automorphism group of G.