bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prospective Study of the Correlation Between Postoperative Computed Tomography Scan and Primary Surgeon Assessment in Patients With Advanced Ovarian, Tubal, and Peritoneal Carcinoma Reported to Have Undergone Primary Surgical Cytoreduction to Residual Disease 1 cm or Less
Authors: Chi Dennis S. , Ramirez Pedro T. , Teitcher Jerrold B. , Mironov Svetlana , Sarasohn Debra M. , Iyer Revathy B. , Eisenhauer Eric L. , Abu-Rustum Nadeem R. , Sonoda Yukio , Levine Douglas A. , Brown Carol L. , Aghajanian Carol , Gershenson David M. , Hoskins William J. , Hricak Hedvig , Barakat Richard R. 
Published: October 2007

Purpose To compare surgeons' operative assessments of residual disease (RD) to those identified on postoperative computed tomography (CT) scans in patients with advanced ovarian carcinoma reported to have undergone optimal primary cytoreduction. Patients and Methods All patients at one of two institutions, who were scheduled to have primary surgery for presumed advanced ovarian cancer, were asked to consent to a postoperative CT scan if cytoreduction to ≤ 1 cm RD was reported. CT scan findings were graded using a qualitative analysis scale from 1 (normal) to 5 (definitely malignant). Results From January 2001 to September 2006, 285 patients were enrolled. A total of 78 patients met eligibility criteria and had postoperative CT scans. In 41 cases (52%), postoperative scan findings correlated with the surgical report of no RD more than 1 cm, and in seven cases (9%), the CT findings were indeterminate. In 10 cases (13%), more than 1 cm RD was noted by the radiologist as probably malignant, and in 20 cases (26%), definitely malignant. In these 30 cases, the radiologically reported median largest residual mass was 1.9 cm (range, 1.1 to 5.1), with RD more than 1 cm reported most commonly in the right upper quadrant (15 patients [50%]) and central abdomen (nine patients [30%]). Conclusion There was only a 52% correlation between surgeons' assessments and postoperative CT scan evaluations of RD in patients reported to have undergone optimal cytoreduction. Further study is required to determine whether this lack of correlation is due to rapid interval tumor regrowth, RD underestimated by the surgeons, and/or overestimated by the radiologists; and to determine the clinical implications of these discrepancies.
Phase III Trial of Protracted Compared With Split-Course Chemoradiation for Esophageal Carcinoma: Fédération Francophone de Cancérologie Digestive 9102
Authors: Crehange Gilles , Maingon Philippe , Peignaux Karine , N′guyen Tan Dat , Mirabel Xavier , Marchal Christian , Verrelle Pierre , Roullet Bernard , Bonnetain Franck , Bedenne Laurent 
Published: October 2007

Purpose Chemoradiotherapy (CRT) is an alternative to surgery for resectable locally advanced esophageal carcinoma (RLA-EC). We investigated the heterogeneity of the treatment benefits across subgroups of patients, defined according to the radiation scheme. Patients and Methods Between February 1993 and December 2000, 451 patients were enrolled. The following two schemes were allowed: protracted radiotherapy (P-RT), which scheduled 46 Gy over 4.5 weeks or split-course radiotherapy (SC-RT) with two 1-week courses of 15 Gy. Two courses of cisplatin and fluorouracil were delivered concomitantly. In case of exclusive CRT, a further course of 20 Gy over 2 weeks in the P-RT group and one 1-week course of 15 Gy in the SC-RT group were delivered with three courses of chemotherapy. SC-RT and P-RT were administered to 285 patients (64%) and 161 patients (36%), respectively. Results For P-RT versus SC-RT, the response rate to induction CRT was 67% v 68%, respectively (P = .09), and 2-year local relapse-free survival rate was 76.7% v 56.8%, respectively (P = .002). Shorter tumor length and P-RT were associated with better local control in multivariate analysis (P = .002 for both). After a median follow-up time of 47.4 months, 2-year overall survival rate was 37.1% for P-RT compared with 30.5% for SC-RT (P = .25). Independent prognostic factors on survival were tumor diameter (P = .02), weight loss of 10% or less (P = .05), and response to induction CRT (P = .002). Conclusion Patients with RLA-EC treated with P-RT had better local control than patients treated with SC-RT. Response to induction CRT is a determinant prognostic factor on survival.
Prophylactic Cranial Irradiation in Operable Stage IIIA Non–Small-Cell Lung Cancer Treated With Neoadjuvant Chemoradiotherapy: Results From a German Multicenter Randomized Trial
Authors: Pöttgen Christoph , Eberhardt Wilfried , Grannass Andreas , Korfee Soenke , Stüben Georg , Teschler Helmut , Stamatis Georgios , Wagner Horst , Passlick Bernward , Petersen Volker , Budach Volker , Wilhelm Hans , Wanke Isabel , Hirche Herbert , Wilke Hans-Jochen , Stuschke Martin 
Published: October 2007

Purpose To investigate the role of prophylactic cranial irradiation (PCI) within a trimodality protocol (chemotherapy, chemoradiotherapy, surgery) for patients with operable stage IIIA non–small-cell lung cancer (NSCLC). Patients and Methods After mediastinoscopic staging, patients with operable stage IIIA NSCLC were enrolled to a German multicenter trial and randomly assigned to receive either primary resection followed by adjuvant thoracic radiation therapy (50 to 60 Gy; arm A) or preoperative chemotherapy (cisplatin/etoposide [PE]; three cycles) followed by concurrent chemoradiotherapy (PE plus 45 Gy; 1.5 Gy twice per day) and definitive surgery (arm B), respectively. Patients in arm B were scheduled to receive PCI (30 Gy; 2 Gy daily fractions). Results One hundred twelve patients were randomly assigned between November 1994 and July 2001. One hundred six patients were eligible (arm A: 51, arm B: 55), 90 males and 16 females, 50 with squamous cell, 16 with large cell, five with adenosquamous, and 35 with adenocarcenoma (median age, 57 years; range, 37 to 71 years). Forty-three patients received PCI as scheduled in arm B. Eleven long-term survivors (arm A: four; arm B: seven) underwent a comprehensive neuropsychological examination. PCI significantly reduced the probability of brain metastases as first site of failure (7.8% at 5 years v 34.7%; P = .02), the overall brain relapse rate was reduced comparably (9.1% at 5 years v 27.2%; P = .04). A slightly reduced neurocognitive performance in comparison with the age-matched normal population was found for patients in both treatment groups. No significant difference between patients who were treated with or without PCI could be noted. Conclusion PCI is effective in preventing brain metastases following this aggressive trimodality approach. Neurocognitive late effects are not significantly different between patients treated with or without PCI.
Video-Assisted Thoracic Surgery Lobectomy: Report of CALGB 39802—A Prospective, Multi-Institution Feasibility Study
Authors: Swanson Scott J. , Herndon James E. , D'Amico Thomas A. , Demmy Todd L. , McKenna Robert J. , Green Mark R. , Sugarbaker David J. 
Published: October 2007

Purpose To evaluate the technical feasibility and safety of video-assisted thoracic surgery (VATS) lobectomy for small lung cancers. Patients and Methods The Cancer and Leukemia Group B 39802 trial was a prospective, multi-institutional study designed to elucidate the technical feasibility of VATS in early non–small-cell lung cancer (NSCLC) using a standard definition for VATS lobectomy (one 4- to 8-cm access and two 0.5-cm port incisions) that mandated videoscopic guidance and a traditional hilar dissection without rib spreading. Between 1998 and 2001, 128 patients with peripheral lung nodules ≤ 3 cm in size with suspected NSCLC were prospectively registered for VATS lobectomy. Results One hundred twenty-seven patients (66 males and 61 females; median age, 66 years; range, 37 to 86 years), with a performance status of 0 (74%) or 1 (26%), underwent surgery. Patients with lymph nodes more than 1 cm by computed tomography scan underwent mediastinal lymph node sampling to rule out N2 disease. One hundred eleven patients (87%) had stage I lung cancer, and 96 (86.5%) of these 111 patients underwent successful VATS lobectomies. The median procedure length was 130 minutes (range, 47 to 428 minutes), and median chest tube duration was 3 days (range, 1 to 14 days). Fifty-eight (60%) of 97 patients underwent diagnostic biopsy at lobectomy. Within 30 days, three (2.7%) of 111 patient deaths occurred, none of which were directly related to VATS technique; seven (7.4%) of 95 patients had grade 3 or greater complications, with only one case of bleeding. Conclusion A standardized approach to VATS lobectomy as specifically defined with avoidance of rib spreading is feasible.
Mortality in Acromegaly: A Metaanalysis
Authors: Dekkers O. M. , Biermasz N. R. , Pereira A. M. , Romijn J. A. , Vandenbroucke J. P. 
Published: October 2007

Abstract
Context: Several studies have assessed mortality risk in patients treated for acromegaly. All studies found a mortality that was higher than expected for the general population, but most of these increases were not statistically significant. For this reason, it is not formally established whether mortality in acromegaly is different from the general population.
Objective: The objective of the study was to address the all-cause mortality risk in patients with acromegaly.
Design: The study was a metaanalysis.
Methods: Sixteen studies on mortality in patients with acromegaly were included. The principal outcome of the metaanalysis was the weighted average of the standardized mortality ratio (SMR) of all studies. In addition, we performed a subgroup analysis of studies in which more than 80% of the patients were treated by transsphenoidal approach.
Results: The weighted mean of the SMR from all 16 studies was 1.72 (95% confidence interval 1.62–1.83). In studies with transsphenoidal surgery as the primary therapy, the weighted mean of the SMR was 1.32 (95% confidence interval 1.12–1.56).
Conclusions: This metaanalysis shows increased all-cause mortality in acromegalic patients, compared with the general population, even after transsphenoidal surgery.
Plasma Amino-Terminal Pro C-Type Natriuretic Peptide in the Neonate: Relation to Gestational Age and Postnatal Linear Growth
Authors: Prickett Timothy C. R. , Dixon Bronwyn , Frampton Chris , Yandle Timothy G. , Richards A. Mark , Espiner Eric A. , Darlow Brian A. 
Published: October 2007

AbstractContext: C-type natriuretic peptide (CNP) plays an essential role in endochondral bone growth. Insight into CNP’s paracrine actions is possible using plasma measurements of the amino-terminal pro C-type natriuretic peptide (NTproCNP). Whether correlations of NTproCNP with linear growth, as found in children and lambs, apply in neonates is unknown.Objectives: Our objective was to determine the effects of prematurity, gender, and antenatal steroids on plasma NTproCNP at birth, and serial changes in hormone concentrations, linear growth, and markers of bone turnover in the first month of postnatal life.Design and Setting: This is a prospective study of newborn infants admitted to an intensive care unit.Subjects: A total of 48 infants (four gestation groups) were enrolled. Umbilical cord samples were also obtained from 39 healthy term infants.Main Outcome Measures: Plasma NTproCNP and CNP were measured in cord plasma. In enrolled neonates, serial measurements of hormone concentrations and markers of bone turnover were related to tibial growth velocity as measured by knemometry.Results: Cord plasma NTproCNP was inversely related to gestational age (r = −0.35; P = 0.003) and was higher in males (P &lt; 0.001). Plasma NTproCNP (P = 0.016) and CNP (P &lt; 0.001) increased within the first week of life, the increase relating inversely to gestational age (r = −0.64; P &lt; 0.001). Plasma NTproCNP at 1 wk was strongly correlated with linear growth velocity (r = 0.49; P &lt; 0.001), and also at 2–4 wk, the relation being stronger than observed between bone turnover markers and growth velocity.Conclusions: In neonates with diverse disorders affecting growth and nutrition, plasma NTproCNP was strongly correlated with linear growth during the first 4 wk of postnatal life and may prove to be a novel marker of growth plate activity in neonates.
Book Reviews
Authors: Frey Mattias , de Seife Ethan 
Published: October 2007

Screening the Past: Memory and Nostalgia in Cinema, Pam Cook (2005) London, New York: Routledge, 224 pp., ISBN: 0415183758, paperback, 17.99, 31.95
Dudley Murphy: Hollywood Wild Card, Susan Delson, (2006) Minneapolis: University of Min-nesota Press, 272 pp., ISBN 0816646546 (hbk),
27.95
Problematic macrofossils from Ediacaran successions in the North China and Chaidam blocks: implications for their evolutionary roots and biostratigraphic significance
Authors: Shen Bing , Xiao Shuhai , Dong Lin , Chuanming Zhou , Liu Jianbo 
Published: October 2007

Upper Neoproterozoic successions in the North China and nearby Chaidam blocks are poorly documented. North China successions typically consist of a diamictite unit overlain by siltstone, sandstone, or slate. Similar successions occur in Chaidam, although a cap carbonate lies atop the diamictite unit. The diamictites in both blocks have been variously interpreted as Cryogenian, Ediacaran, or Cambrian glacial deposits. In this paper, we describe problematic macrofossils collected from slate of the upper Zhengmuguan Formation in North China and sandstone of the Zhoujieshan Formation in Chaidam; both fossiliferous formations conformably overlie the aforementioned diamictites. Some of these fossils were previously interpreted as animal traces. Our study recognizes four genera and five species—Helanoichnus helanensisYang in Yang and Zheng, 1985,Palaeopascichnus minimusn. sp.,Palaeopascichnus meniscatusn. sp.,Horodyskia moniliformis? Yochelson and Fedonkin, 2000, andShaanxilithescf.ningqiangensisXing et al., 1984. None of these taxa can be interpreted as animal traces. Instead, they are problematic body fossils of unresolved phylogenetic affinities. The fundamental bodyplan similarity betweenHorodyskiaandPalaeopascichnus, both with serially repeated elements, indicates a possible phylogenetic relationship. Thus, at least some Ediacaran organisms may have a deep root becauseHorodyskiaalso occurs in Mesoproterozoic successions.Among the four genera reported here,PalaeopascichnusPalij, 1976 andShaanxilithesXing et al., 1984 have been known elsewhere in upper Ediacaran successions, including the Dengying Formation (551-542 Ma) in South China. If these two genera have biostratigraphic significance, the fossiliferous units in North China and Chaidam may be upper Ediacaran as well. Thus, the underlying diamictites in North China and Chaidam cannot be of Cambrian age, although their correlation with Ediacaran and Cryogenian glaciations remains unclear. As no other Neoproterozoic diamictite intervals are known in North China and Chaidam, perhaps only one Neoproterozoic glaciation is recorded in that area.
Sediment quality assessment and dredged material management in Spain: Part I, application of sediment quality guidelines in the bay of Santander
Authors: Alvarez-Guerra Manuel , Viguri Javier R , Casado-Martínez M Carmen , DelValls T Ángel 
Published: October 2007

Abstract
Sediments are an essential component of aquatic ecosystems that must be assessed and managed properly. The use of quantitative environmental quality standards derived from consideration of sediment quality guidelines (SQGs) can be effective as part of a tiered risk assessment approach. In Part I of this 2-part paper addressing sediment quality assessment and dredged material management in Spain, different SQG methods are used to evaluate sediment quality in the Bay of Santander, located in the Cantabric Sea along the northern coast of Spain, and to guide development of empirically derived SQGs for marine sediments. The results of the study indicate a great heterogeneity of SQGs, both with regard to the numeric values for a particular chemical and the number of substances for which SQGs have been derived. The analysis highlights the scarce development of empirical SQGs for priority substances identified in current European Union water policy. Nonetheless, the application of SQGs makes it possible to classify different zones of sediment quality in the Bay of Santander. Part II of this 2-part paper considers the environmental impacts of dredged material disposal. Legislation and criteria used to regulate dredged material disposal at sea in different European countries are reviewed, and action levels derived by different countries were used to evaluate management of dredged sediments from Cádiz Bay, located on the South Atlantic coast of Spain.
Evaluating consistency of best professional judgment in the application of a multiple lines of evidence sediment quality triad
Authors: Bay Steven , Berry Walter , Chapman Peter M , Fairey Russell , Gries Tom , Long Edward , MacDonald Don , Weisberg Stephen B 
Published: October 2007

Abstract
The bioavailability of sediment-associated contaminants is poorly understood. Often, a triad of chemical concentration measurements, laboratory sediment toxicity tests, and benthic infaunal community condition is used to assess whether contaminants are present at levels of ecological concern. Integration of these 3 lines of evidence is typically based on best professional judgment by experts; however, the level of consistency among expert approach and interpretation has not been determined. In this study, we compared the assessments of 6 experts who were independently provided data from 25 California embayment sites and asked to rank the relative condition of each site from best to worst. The experts were also asked to place each site into 1 of 6 predetermined categories of absolute condition. We provided no guidance regarding assessment approach or interpretation of supplied data. The relative ranking of the sites was highly correlated among the experts, with an average correlation coefficient of 0.92. Although the experts' relative rankings were highly correlated, the categorical assessments were much less consistent, with only 1 site out of 25 assigned to the same absolute condition category by all 6 experts. Most of the observed categorical differences were small in magnitude and involved the weighting of different lines of evidence in individual assessment approaches, rather than interpretation of signals within a line of evidence. We attribute categorical differences to the experts' use of individual best professional judgment and consider these differences to be indicative of potential uncertainty in the evaluation of sediment quality. The results of our study suggest that specifying key aspects of the assessment approach a priori and aligning the approach to the study objectives can reduce this uncertainty.
Design and application of a transparent and scalable weight-of-evidence framework: An example from Wabamun Lake, Alberta, Canada
Authors: McDonald Blair G , deBruyn Adrian MH , Wernick Barbara G , Patterson Luanne , Pellerin Normand , Chapman Peter M 
Published: October 2007

AbstractA weight-of-evidence (WOE) framework was developed to evaluate potential effects on the aquatic ecosystem of Wabamun Lake (Alberta, Canada) associated with the release of Bunker “C” oil after a train derailment. The wide variety of stakeholders and interested regulatory agencies made it necessary to develop a consistent and transparent approach to assessing ecological effects on multiple ecosystem components within the lake with the use of a large number of lines of evidence (LOEs). Consequently, a scalable WOE framework was necessary to integrate the findings of 38 different LOEs. A priori and a posteriori weighting factors were applied to each individual LOE, and a combination of numeric and nonnumeric rating systems was used to integrate LOEs into an overall WOE conclusion for 5 different ecosystem components. We provide guidance regarding the development of a WOE framework and emphasize techniques that enhance the application of best professional judgement during the WOE process.
Clinical Evaluation of Partial‐ and Full‐Mouth Scaling in the Treatment of Chronic Periodontitis
Authors: Knöfler Gerhild U. , Purschwitz Regina E. , Jentsch Holger F.R. 
Published: October 2007

Background: Full‐mouth scaling (FMS) is claimed by some researchers to be superior to standard scaling and root planing (SRP). The aim of the present study was to evaluate clinical outcomes of two modalities of non‐surgical periodontal therapy for patients with chronic periodontitis.Methods: In a prospective, randomized, controlled clinical study, 37 subjects with chronic periodontitis were treated by SRP in two quadrants at 4‐week intervals (N = 20) or by FMS (N = 17). Clinical attachment level (CAL), probing depth (PD), and bleeding on probing (BOP) were recorded at premolar and molar teeth at baseline and after 6 and 12 months.Results: Both therapies resulted in significant improvements of all clinical variables. After 12 months, CAL at pockets with PDs of 4 to 6 mm was reduced significantly from 4.5 ± 0.8 mm to 3.4 ± 1.0 mm with SRP and from 4.7 ± 0.9 mm to 3.8 ± 1.1 mm with FMS (P <0.001). PD decreased from 4.4 ± 0.6 mm to 3.3 ± 0.9 mm in the SRP group and from 4.5 ± 0.7 mm to 3.5 ± 1.0 mm in the FMS group (P <0.001). BOP was reduced from 63.6% ± 45.3% to 29.0% ± 42.6% in the SRP group and from 59.6% ± 43.8% to 28.6% ± 38.3% in the FMS group (P <0.001 and P = 0.001, respectively). There were no significant differences between the groups with respect to CAL gain, PD, and BOP reduction.Conclusion: Both therapy modalities have the same positive influence on clinical outcome at premolar and molar teeth with PDs of 4 to 6 mm.
Treatment of Intrabony Defects Using Guided Tissue Regeneration and Autogenous Spongiosa Alone or Combined With Hydroxyapatite/β‐Tricalcium Phosphate Bone Substitute or Bovine‐Derived Xenograft
Authors: Zafiropoulos Gregory‐George K. , Hoffmann Oliver , Kasaj Adrian , Willershausen Brita , Weiss Oren , Van Dyke Thomas E. 
Published: October 2007

Background: The aim of this case‐control study was to investigate the clinical regeneration of deep intrabony defects using guided tissue regeneration (GTR) with autogenous spongiosa (ASB) alone or using GTR with a mixture of ASB with a bovine‐derived xenograft (BDX) or a synthetic composite bone substitute (hydroxyapatite/β‐tricalcium phosphate [HA/β‐TCP]).Methods: Sixty‐four patients with a total of 93 intrabony defects of 2‐ or 3‐wall morphology and an intrabony component (IC) ≥4 mm participated in this study. Defects were treated with a bioabsorbable membrane and ASB alone or ASB mixed with HA/β‐TCP or BDX. Clinical parameters measured at baseline and 12 months after surgery included IC, bleeding on probing (BOP), and plaque accumulation (PLI). Vertical bone gain (VBG) and percentage relative bone gain (RBG) were used as indicators of treatment efficacy. A stringent plaque control regimen was enforced in all patients during the 12‐month observation period.Results: At baseline, no statistically significant differences in any of the clinical parameters were observed between the groups. At 12 months, HA/β‐TCP and BDX treatments produced similar improvements in intrabony tissue regeneration as shown by VBG (P = 0.616) and RBG (P = 0.826) with significantly better outcomes than ASB alone (P <0.0001). Changes in BOP and PLI did not differ significantly between the groups.Conclusion: The combined use of ASB with BDX or HA/β‐TCP led to significantly greater gain of clinical attachment and hard tissue formation compared to the use of ASB alone.