bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of the reliability and validity of the arthritis impact measurement scales for children with juvenile arthritis
Authors: Coulton Claudia J. , Zborowsky Elizabeth , Lipton Judith , Newman Arthur J. 
Published: February 2007

AbstractThere are few multidimensional measures of functional status in children, and none have been developed for children with juvenile arthritis (JA). This report describes an attempt to apply selected components of the Arthritis Impact Measurement Scales (AIMS), which were developed and validated for adults, to a sample of children with active JA (n = 60) or inactive JA (n = 17). Our results suggest that the Pain scale and the Physical Activity scale are the most reliable measures for children with JA; the correlations of the Pain scale, Physical Activity scale, and Dexterity scale results with the clinical measures of JA diagnostic category and joint count support the convergent validity of these scales for the active JA group; and the AIMS revised Physical Disability dimension and the Pain dimension, used to predict the children's classification in the active or inactive JA group, evidence discriminant validity. Additional studies of children with a wider range of impairments are needed to further assess the usefulness of the AIMS for children with JA.
Hypertrophic osteoarthropathy, cutaneous vasculitis, and mixed‐type cryoglobulinemia in a patient with nasopharyngeal carcinoma
Authors: Miyachi Hayato , Akizuki Masashi , Yamagata Hajime , Mimori Tsuneyo , Yoshida Shunji , Homma Mitsuo 
Published: February 2007

AbstractWe describe a 27‐year‐old woman with a primary nasopharyngeal carcinoma who developed hypertrophic osteoarthropathy and cutaneous vasculitis. Her serum contained antibodies to Epstein‐Barr virus and U1 RNP antigens. Cryoproteins isolated from her serum contained antibodies to U1 RNP and a protein with a molecular weight of 32 kd which reacted specifically with antibodies to U1 RNP. HLA typing revealed HLA‐B7 and DR1; these have been reported to be increased in Japanese patients with rheumatic diseases who have autoantibodies to U1 RNP. These findings indicate that some features of the paraneoplastic syndrome in this patient might have been caused by immune complexes, part of which were formed by specific autoantibodies produced under genetically controlled conditions of immune responsiveness.
Marked increase in the frequency of psoriatic arthritis in psoriasis patients with hla–dr+ keratinocytes
Authors: Gottlieb Alice B. , Fu Shu Man , Carter D. Martin , Fotino Marilena 
Published: February 2007

AbstractImmunocytochemical studies with a monoclonal anti–HLA–DR antibody were performed on skin sections and keratinocyte (KTC) suspensions obtained from suction blisters of active psoriatic plaques. HLA–DR+ KTCs were found in the plaques of 23 of 38 patients with active psoriasis. Of these 23, 16 had clinical findings typical of psoriatic arthritis (PA); none of the 15 patients who lacked HLA–DR+ KTCs had PA. Although KTC HLA–DR expression was more prevalent in patients with severe skin disease, 7 of the 23 patients with HLA–DR + KTCs in active psoriatic plaques had mild skin disease; 4 of these 7 had PA. Nail pitting or duration of skin disease did not account for increased incidence of PA in patients with HLA–DR+ KTCs. All psoriasis patients with arthritis received nonsteroidal antiinflammatory drug therapy; 14 received additional therapy directed primarily to the cutaneous manifestations of psoriasis. Nine of these noted arthritis improvement with concurrent skin response; however, in 5 patients, arthritis activity increased, despite improvement of the cutaneous disease. Two other patients, treated with methotrexate, also had concurrent skin and joint improvement. These data suggest that psoriasis patients with HLA–DR + KTCs are at increased risk for the development of associated arthritis.
Attributional processes in rheumatoid arthritis patients
Authors: Affleck Glenn , Pfeiffer Carol , Tennen Howard , Fifield Judith 
Published: February 2007

AbstractIn a study of 92 patients with rheumatoid arthritis, we examined patients' beliefs about the causes of their illness, disease flares, and disease remissions, and about the selective incidence of the disease. Numerous self‐report measures were used to elucidate the patients' attitudes and perceptions; the tendency of patients to present themselves in socially desirable ways was taken into account and was found not to influence the study results. The causes for the illness that were most frequently cited by patients were heredity (34.7%), autoimmune factor (24.4%), personal behaviors (22.8%), and psychological stress (22.8%). Patients who were more actively searching for the causes of the illness and who continued to ask “Why me?” reported greater functional problems and a greater sense of helplessness. The most frequently cited causes for symptom flares were psychological stress (45.5%), changes in weather (34.0%), and excessive physical activity (34.1%). Symptom remissions were most frequently believed to be related to medication changes (49.4%) and the absence of psychological stress (21.0%). Several of these causal beliefs were related to perceptions of helplessness and the illness' predictability and to health care providers' assessments of disease severity and patients' psycho‐social adjustment.
Transverse myelitis and optic neuritis in systemic lupus erythematosus: a case report with magnetic resonance imaging findings
Authors: Kenik Jay G. , Krohn Kelly , Kelly Richard B. , Bierman Martin , Hammeke Michael D. , Hurley John A. 
Published: February 2007

AbstractWe describe a patient with systemic lupus erythematosus who developed transverse myelitis and optic neuritis. Magnetic resonance imaging showed the presence of an abnormal signal in a normal‐sized spinal cord which corresponded to the patient's neurologic deficit. No abnormality was recognized in either optic nerve. Magnetic resonance may prove to be a useful imaging modality for the diagnosis of a transverse myelopathy in systemic lupus erythematosus.
Inherited deficiency of erythrocyte complement receptor type 1 does not cause susceptibility to systemic lupus erythematosus
Authors: Moldenhauer F. , David J. , Fielder A. H. L. , Lachmann P. J. , Walport M. J. 
Published: February 2007

AbstractThere is a deficiency of complement receptor type 1 (CR1) on the erythrocytes of patients with systemic lupus erythematosus (SLE). This receptor is involved in the processing of immune complexes. Whether the deficiency is inherited or acquired has been the subject of controversy. A restriction fragment length polymorphism (RFLP), identified using a complementary DNA probe for CR1, has been correlated with the numeric expression of CR1 on normal erythrocytes. The gene frequency for the 2 alleles defined by this RFLP was compared in 44 patients with SLE (from 42 families), 43 of their consanguineous relatives, and 50 nonrelated normal subjects. The gene frequency for the alleles correlating with high and low expression of CR1 was 0.73 and 0.27, respectively, in the normal subjects. The gene frequency was not significantly different in the SLE patients. However, the SLE patients expressed fewer CR1 molecules per erythrocyte within each genotype, compared with normal subjects and compared with their consanguineous relatives. The low allele for numeric expression of CR1 on erythrocytes is not a disease susceptibility gene for SLE.
Cartilage proteoglycans in synovial fluid and serum in patients with inflammatory joint disease. relation to systemic treatment
Authors: Saxne Tore , ård Dick Heineg , Wollheim Frank A. 
Published: February 2007

AbstractProteoglycan concentrations in knee joint synovial fluid and in serum from patients with various inflammatory arthritides were studied using an enzymelinked immunosorbent assay. Patients with reactive arthritis, calcium pyrophosphate arthropathy, and juvenile rheumatoid arthritis (age < 20 years) had the highest synovial fluid concentrations. These values differed significantly (P < 0.001) from those in patients with rheumatoid arthritis, psoriatic arthropathy, and chronic HLA–B27–associated arthropathy. Rheumatoid arthritis patients receiving low‐dose prednisolone treatment had higher synovial fluid (P = 0.006) and serum (P < 0.001) proteoglycan concentrations than did those taking nonsteroidal antiinflammatory drugs or slowacting antirheumatic drugs. Serum proteoglycan concentrations were near the detection limits, and did not correlate with levels found in paired samples of knee joint synovial fluid. Patients with calcium pyrophosphate arthropathy had the highest mean serum level of proteoglycan. This assay of proteoglycan antigens is a useful tool in the study of proteoglycan metabolism in patients with joint disease. With its use, differences between disease groups and effects of theapy can be distinguished.
Deletion of C4A genes in patients with systemic lupus erythematosus
Authors: Kemp Michele E. , Atkinson John P. , Skanes Verna M. , Levine R. Paul , Chaplin David D. 
Published: February 2007

AbstractTo define the relationship between inheritance of major histocompatibility complex (MHC) alleles and susceptibility to the development of systemic lupus erythematosus (SLE), we examined the MHC class I, II, and III phenotypes of white SLE patients and characterized the structures of their class III MHC genes, using Southern blotting. Nine of 88 SLE patients (10.2%) were C4A null. As detected by Southern blot analysis, the C4A gene was deleted from both chromosomes in 8 of the 9 C4A‐null patients. Deletions affecting only 1 chromosome (heterozygous) were detected in the remaining C4A‐null patient and in 34.5% of SLE patients who were not C4A deficient (compared with 12.5% of controls; P < 0.05). These results indicate that deletion of the C4A gene is a common genetic marker for SLE. Deletions of C4A were observed most commonly as part of the HLA–B8;DR3 extended haplotype, although deletions were also detected in different HLA haplotypes. Because of the critical role of C4A in the processing of immune complexes, deficiency of C4A may, itself, confer susceptibility to the development of SLE.
Thromboangiitis obliterans (buerger's disease) and smokeless tobacco
Authors: O'dell James R. , Linder James , Markin Rodney S. , Moore Gerald F. 
Published: February 2007

AbstractThromboangiitis obliterans, a distinct clinical and pathologic entity characterized by segmental inflammatory and proliferative lesions of the tunica media of small arteries and veins, has been reported frequently in men who have a history of heavy cigarette smoking. We report a case of thromboangiitis obliterans in a 38‐year‐old man that was clearly associated with the use of smokeless (chewing) tobacco. In addition to a physical history and examination and laboratory evaluation, a biopsy of the skin and deep subcutaneous tissue of the patient's left thigh was performed, and this revealed occlusion of 2 large dermal blood vessels by a highly organized thrombus. A regimen of nifedipine and antiplatelet therapy, plus complete abstinence from tobacco, resulted in resolution of the patient's symptoms and pain. Our findings may be of particular importance in view of the increasing popularity of smokeless tobacco and the complications which may result from its use.
Systemic lupus erythematosus with jaccoud's arthropathy mimicking juvenile rheumatoid arthritis
Authors: Martini Alberto , Ravelli Angelo , Viola Stefania , Burgio Roberto G. 
Published: February 2007

AbstractWe describe a girl who presented at age 5 with objective signs of arthritis and was initially diagnosed as having juvenile rheumatoid arthritis. Over the following years, she developed slowly progressive joint deformities indicative of Jaccoud's arthropathy. When she was 11 years old, symptoms typical of systemic lupus erythematosus appeared, accompanied by anti‐DNA antibodies. This case illustrates that in children also, Jaccoud's arthropathy may be a precocious manifestation of systemic lupus erythematosus.
Sickle cell crisis following intraarticular steroid therapy for rheumatoid arthritis
Authors: Gladman Dafna D. , Bombardier Claire 
Published: February 2007

AbstractWe describe 2 patients who had coexistent rheumatoid arthritis and sickle cell disease. Both patients developed sickle cell crises following intraarticular injection of corticosteroids to control their arthritis. The mechanism of this phenomenon is not clear, but it is suggested that intraarticular steroids be used with caution in patients with sickle cell disease.
Glutathione peroxidase activity in patients with rheumatoid arthritis and in normal subjects: effects of long‐term selenium supplementation
Authors: Tarp Ulrik , Hansen Jens C. , Overvad Kim , Thorling Eivind B. , Tarp Britta D. , Graudal Hans 
Published: February 2007

AbstractThe effects of dietary supplementation with selenium were studied in 6 patients with severe, active rheumatoid arthritis (RA) and in 6 healthy control subjects. Initial concentrations of Se in red blood cells and in serum, and the activity of the Se‐dependent enzyme glutathione peroxidase (GSH‐Px) in red blood cells, serum, and granulocytes were significantly lower in RA patients compared with controls. During Se supplementation, however, the differences in Se levels and in GSH‐Px activity between the 2 groups disappeared, except that, in RA patients, GSH‐Px activity in granulocytes increased but remained significantly lower than in controls.
Hemodialysis is not essential for the development of destructive spondylarthropathy in patients with chronic renal failure
Authors: Alcalay Michel , Goupy Marie‐Christine , Azais Isabelle , Bontoux Daniel 
Published: February 2007

AbstractSince 1984, there have been several reports of a destructive spondylarthropathy occurring in patients who have received hemodialysis over a long period of time. Two cases of a similar syndrome were observed in nonhemodialyzed patients with chronic renal failure, one of whom underwent a lumbar disc excision. The results of disc examination and of radiographic and biologic investigations prompted reconsideration of factors previously considered to be pathogenetic (amyloidosis, hydroxyapatite crystal deposition, aluminum toxicity), except one: secondary hyperparathyroidism.
Remission of rheumatoid arthritis with the successful treatment of acute myelogenous leukemia with cytosine arabinoside, daunorubicin, and m‐AMSA
Authors: Roubenoff Ronenn , Jones Richard J. , Karp Judith E. , Stevens Mary Betty 
Published: February 2007

AbstractWe describe 2 patients in whom a sustained remission of longstanding rheumatoid arthritis occurred with treatment for acute myelogenous leukemia (cytosine arabinoside, daunorubicin, and m‐AMSA), even though both illnesses had been refractory to therapy with standard disease‐modifying agents. These 2 patients represent the first successful treatment of rheumatoid disease using such an approach.
Radiographic assessment of progression in osteoarthritis
Authors: Altman Roy D. , Fries James F. , Bloch Daniel A. , Carstens John , Derek Mb T. Cooke , Genant Harry , Gofton Philip , Groth Harry , Mcshane Dennis J. , Murphy William A. , Sharp John T. , Spitz Patricia , Williams Catherine A. , Wolfe Frederick 
Published: February 2007

AbstractWe evaluated methods of grading radiologic progression of osteoarthritis (OA). Sets of radiographs were assessed separately by 8 readers who were blinded to the time sequence. Included were radiographs of patients with OA of the hands (24 pairs), hips (40 pairs), and knees (32 pairs). Most films were taken 12–60 months apart. The relative contribution of individual joints (such as particular interphalangeal joints), of observations (such as narrowing or spurs), and of a single joint compartment (such as the medial or lateral compartment of the knee) toward evidence of OA progression was evaluated, as well as the reliability and concordance of scoring, and the sensitivity in detecting change. In assessing OA of the hand, the greatest sensitivity was achieved by reading a single posteroanterior bilateral hand radiograph for narrowing, spurs, and erosions, and scoring 10 joints (second and third distal interphalangeal, second and third proximal interphalangeal, and trapeziometacarpal joints, bilaterally), using a scale of 0–3. In OA of the hip, a single anteroposterior radiograph assessed for joint space narrowing and cyst formation yielded the greatest sensitivity. In OA of the knee, an anteroposterior radiograph, with weight‐bearing, assessed for narrowing, spurs, and sclerosis in both the medial and lateral compartments yielded the greatest sensitivity. These techniques will be useful to the investigator in designing experimental studies and to the clinician in determining the rate of disease progression in an individual patient.
Localization of ro (ss‐a) antigen in the cardiac conduction system
Authors: Deng Jau‐Shyong , Bair Louis W. , Shen‐Schwarz Susan , Ramsey‐Goldman Rosalind , Medsger Thomas 
Published: February 2007

AbstractThe presence of anti‐Ro (SS‐A) antibody in maternal serum has been associated with congenital heart block. Using human sera monospecific for anti‐Ro (SS‐A) antibodies in an indirect immunofluorescence assay, Ro (SS‐A) antigen was found to be present in the nuclei of myocardial cells and cells of the cardiac conduction system. The possible relationship between the location of Ro (SS‐A) antigen, anti‐Ro (SS‐A) antibody, and heart block is discussed.
Functional disability due to back pain. a population‐based study indicating the importance of socioeconomic factors
Authors: Deyo Richard A. , Tsui‐Wu Yuh‐Jane 
Published: February 2007

AbstractUsing national survey data, we examined correlates of disability due to low back pain in 1,516 persons who had back pain. Greater education level correlated significantly (P < 0.001) with fewer disability days (i.e., days of activity limitation, absence from work, confinement to bed, or reduced housework), even after controlling for severity, sciatica, occupation, and age. Findings in men differed from those in women; education level was a strong correlate for men only. For work absenteeism, low income was a stronger correlate than education. These data support the importance of social factors in the prognosis of some musculoskeletal diseases.
Survival in systemic lupus erythematosus. a multivariate analysis of demographic factors
Authors: Studenski Stephanie , Caldwell David S. , Allen Nancy B. , Rice John R. , Polisson Richard P. 
Published: February 2007

AbstractWe analyzed survival rate and important clinical outcomes in 411 patients with systemic lupus erythematosus who were seen at our center between 1969 and 1984. All eligible subjects met 4 of the revised American Rheumatism Association criteria for systemic lupus erythematosus and all were seen within 2 years of diagnosis. Mean followup was 75.6 months. Multivariate analysis suggested significant independent effects of race (P = 0.0139) and socioeconomic status (P = 0.0326) on survival. No evidence of diminished lupus‐related mortality with age was documented. Previously reported findings of improved survival rate with age may have been confounded by differences in race distribution between the younger‐ and older‐onset groups.
Inhibitor of interleukin‐2 synthesis and response in rheumatoid synovial fluid
Authors: Kashiwado Takamichi , Miossec Pierre , Oppenheimer‐Marks Nancy , Ziff Morris 
Published: February 2007

AbstractWe studied the effects of a factor present in rheumatoid arthritis (RA) synovial fluid (SF) on interleukin‐2 (IL‐2)‐dependent cell proliferation and on the production of IL‐2 by mitogen‐stimulated peripheral blood mononuclear cells. RA SF suppressed the responsiveness of a mouse T cell line (HT‐2) to IL‐2, indicating that it contained an inhibitor of the IL‐2 response. When RA SF was fractionated by Sephadex G‐200 gel filtration, the inhibitory activity was detected mainly in fractions with a molecular weight of approximately 150,000, but was also found in a 15—19‐kd fraction. Removal of IgG from the 150‐kd fraction, by means of an anti‐IgG affinity column, did not reduce the activity of the fraction, nor was activity found in the eluted IgG. The inhibitory fractions reduced mouse thymocyte pro‐liferative responses to IL‐1 in the presence of phytohemagglutinin, and reduced the production of IL‐2 by human peripheral blood mononuclear cells, but did not inhibit IL‐1‐induced human foreskin fibroblast proliferation; this suggests that the factor was not an IL‐1 inhibitor. The inhibitory activity of the RA SF factor was blocked by an antibody against an inhibitor of IL‐2 that was purified from a culture of the human monocytic leukemia cell line, THP‐1. This finding also supports the conclusion that RA SF contains an IL‐2 inhibitory factor. The observed inhibition of both IL‐2 synthesis and IL‐2 response suggests that the target of the inhibition was the T lymphocyte.
Metacarpophalangeal arthropathy associated with manual labor (missouri metacarpal syndrome). clinical, radiographic, and pathologic characteristics of an unusual degenerative process
Authors: Williams William V. , Cope Ray , Gaunt William D. , Adelstein Edward H. , Hoyt Terry S. , Singh Amolak , Pressly Thomas A. , Bs Roy English, , Ralph H. Schumacher , Walker Sara E. 
Published: February 2007

AbstractWe describe 7 manual laborers with painful, palpably enlarged metacarpophalangeal joints. Characteristic radiographic changes were joint space loss, prominent osteophytes, and cystic metacarpal heads most prominent in the second and third metacarpophalangeal joints. In 3 of 4 patients, joint biopsy specimens showed subsynovial fibrosis and villous hyperplasia. All 7 patients had similar backgrounds of heavy work demanding sustained gripping motions of both hands, for periods that exceeded 30 years. We designated their condition metacarpophalangeal arthropathy associated with manual labor.
Effect of synthetic calcium pyrophosphate and hydroxyapatite crystals on the interaction of human blood mononuclear cells with chondrocytes, synovial cells, and fibroblasts
Authors: Dayer Jean‐Michel , Evêquoz Vlasta , Zavadil‐Grob Carolyn , Grynpas Marc D. , Cheng Pei‐Tak , Schnyder Jörg , Trechsel Ulrich , Fleisch Herbert 
Published: February 2007

AbstractSynthetic calcium pyrophosphate dihydrate crystals and, to a lesser extent, synthetic hydroxyapatite crystals increased the amount of interleukin‐1/mononu‐clear cell factor released by human blood monocytes, as measured by collagenase and prostaglandin E2 production by rabbit chondrocytes, human dermal fibroblasts, and adherent rheumatoid synovial cells. The same crystals also directly induced collagenase and prostaglandin E2 secretion by rabbit chondrocytes, and potentiated the action of interleukin‐1/mononuclear cell factor on chondrocytes. These mechanisms may be important in the pathogenesis of the destructive arthropathies associated with these crystals.
Correlation between systemic lupus erythematosus and T4 epitope phenotype
Authors: Stohl William , Singer Joyce Z. 
Published: February 2007

AbstractThree groups of black subjects (systemic lupus erythematosus patients, patients with nonrheumatic disease, and normal subjects) were screened for the expression of the T4 epitope, as recognized by the monoclonal antibody OKT4. We found that the T cell subsets within each group were similar, regardless of the T4 epitope phenotype (intact, intermediate, or deficient). In the subgroup of Jamaican subjects, there was an association between systemic lupus erythematosus and the T4 epitope—intermediate and T4 epitope—deficient phenotypes; this association was not detected in the non‐Jamaican population.