bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of thymic factors on growth of experimental tumors
Authors: Anghileri L. J. , Kelemen N. , Lasmoles F. , Talbot J. N. , Milhaud G. 
Published: February 2007

AbstractThe effects of thymic factors on the growth of a chemically induced tumor have been studied, The thymic factors were obtained by a gentle isolation procedure which minimizes loss of material and biological activity. The administration of the thymic factors neither influenced the development or growth of the tumor nor the weight of the thymus or the spleen. A bigger thymus and a smaller spleen were observed in animals rejecting the tumor, whether or not they received the thymic factors.
Case report: Malignant melanoma arising during drug therapy for vitiligo
Authors: Forrest John B. , Forrest Herbert J. 
Published: February 2007

AbstractA 30‐year‐old white male developed cutaneous patches of depigmentation which were treated with Trioxsalen ingested before daily sunbathing. A darkly pigmented lesion which appeared three weeks later on his back was widely excised and classified as a low‐grade malignancy. Although the treatment of vitiligo with plants containing photodynamically active compounds dates back as far as 1400 BC, the modern period of research began only in the 1930's leading to the development of oral psoralens, a coumarin derivative. In early tests, patients showed increased sunlight tolerance and repigmentation of vitiliginous areas. Although some patients have developed uveitis and vitiligo while being treated for melanoma, previous published reports deny any cutaneous malignancy arising during drug therapy of vitiligo. The associations between vitiligo and melanoma are discussed. The possible causative role of Trioxsalen in etiology of the case presented is discussed.
Carcinomas arising in fibroadenomas: A report of two cases and a review of the literature
Authors: Netto Dymphna , Satchidanand Sateesh K. , Gaeta John F. 
Published: February 2007

AbstractCarcinomas arising in fibroadenomas are rare. Two such cases are being presented; one is of the ductal variety and the other, lobular. Both cases clearly demonstrate the overall configuration of fibroadenomas with foci of in situ and infiltrating carcinoma, the surrounding breast tissue being devoid of malignant changes. The diagnosis was clinically unsuspected in both cases and in only one of them was it suspected at the time of gross pathological examination.The intent of this presentation is to increase general awareness as to the existence of carcinomas arising in fibroadenomas and also to actively discourage the practice of rendering gross pathological diagnoses of fibroadenomas at table diagnosis, however innocuous these neoplasms may appear to be, without microscopic examination by frozen sections.
Clinicomorphologic markers for predicting behavior and guiding therapy for brain tumors
Authors: Parker Oseph C. , Parris Ellen L. , Reyes Patricio F. 
Published: February 2007

AbstractMore specific therapy can be achieved for brain tumors by identifying morphologic markers like primitive neuroectodermal tumor cells that tend to be radioresponsive and spread diffusely through the cerebrospinal fluid (CSF). Utilizing clinical manifestations to suspect and then localize the brain tumor, morphologic markers, that can be appreciated with computerized tomography and cerebral angiography as well as at operation, provide a basis for more aggressive extirpation and the usefulness of radiation and chemotherapy. Metastatic neoplasms possess such markers as tumor hemorrhage and meningeal involvement suggesting specific extraneural sources. In almost half of these patients, cytologic examination of the CSF should help to identify the malignant cells. Although most gliomas do not metastasize either within or outside the central nervous system, the occurrence of primitive neuroectodermal tumor cells (undifferentiated malignant small cells) in about 20% of all glioblastomas implies spread throughout the CSF and some radioresponsiveness. With thorough clinicomorphologic evaluations of all patients with brain tumors in concert with liberal clinical consultations, the aggressive, newer therapeutic modalities can be used more effectively.
Anesthesia and Surgery: A Double‐Edged Sword for the Cancer Patient
Authors: Lundy Joel 
Published: February 2007

AbstractAll therapeutic modalities used in cancer patients are associated with immunosuppression. Anesthesia and surgery represent a double‐edged sword. By removal of gross tumor in many patients a restoration of general immune responses can be documented. In addition, circulating antigen or antigen‐antibody complexes which block tumor‐specific immune responses can be abrogated by removal of bulk tumor. However, animal data indicates that certain anesthetic agents and major surgical procedures may enhance growth of micrometastatic tumor foci. One mechanism by which this occurs might be immunosuppression. The use of immunorestorative drugs in the perioperative period has been able to reverse this phenomenon in animal tumor models.
Treatment of breast cancer with oral four‐drug chemotherapy
Authors: Foley John F. , Kessinger M. Anne , Lemon Henry M. 
Published: February 2007

AbstractSeventy patients with advanced metastatic breast cancer were treated with an oral drug regime of prednisone, cytomel, cytoxan, and methotrexate. One half of the cases (50%) had a response. There were complete remissions in 7%, partial remissions in 27%, and arrests in 16%. The median duration of remissions was 8+ months. There was no significant difference in response between patients with predominant visceral or bone disease nor between pre‐ and post‐menopausal women. One third of non‐hormonally responsive patients responded to this treatment. Side effects consisted predominantly of glucocorticoid change, including cushinoid facies and weight gain. The program was relatively bone marrow sparing. This drug regime is very convenient and safe to give on an outpatient basis.
Papillary carcinoma arising in a papillary cystadenoma of thyroid: A case report
Authors: Honoré Louis H. 
Published: February 2007

AbstractPapillary cystadenoma of the thyroid is a controversial pathologic entity, the existence of which is not universally accepted. Its malignant potential is unknown, with only scant evidence that it may be a rare precursor of the papillary carcinoma. A case is presented as a pathologically documented instance of malignancy arising in a papillary cystadenoma in a 33‐year‐old woman. The clinical implications of this finding are discussed.
Immunity and drug resistance in a mouse glioma
Authors: Miller Elizabeth E. 
Published: February 2007

AbstractThe failure of chemotherapy often results in the outgrowth of drug‐resistant tumor cells, and, since chemotherapy is often combined with immunotherapy, the question arises as to whether immunity directed against the original tumor offers any protection against the drug‐resistant tumor cells. To approach this problem, the immunological relationships between a mouse glioma (GL26) and two FUdR‐resistant transplantable tumor sublines were studied. Immunity was induced in C57BL/6 mice with neuraminidase‐altered GL26 tumor cells. Immunized mice challenged with viable GL26 tumor cells were completely protected, and no tumors grew. Immune mice, when rechallenged with cells from the two FUdR‐resistant tumors, gave greater protection against one of the tumors than the other, but not as much as against the original tumor. The results indicate the drug‐resistant tumor cells have some immunological properties similar to the original tumor line and that further studies such as these might be of value to the staging of chemoimmunotherapy.
Plasma sialyltransferase in patients with breast cancer
Authors: Lee YEU‐Tsu N. , Tokes Zoltan A. , Csipke Csaba P. 
Published: February 2007

AbstractSialyltransferase enzyme levels (Sialtx), CEA, and 10 standard laboratory tests were studied in 50 patients with treated, recurrent, or disseminated breast carcinoma. All groups of patients had elevated mean Sialtx activity (CPM/mg protein) as compared with normal controls. Sialtx levels (expressed as % of normal controls) of patients with disseminated lesions were significantly elevated as compared to patients without evidence of disease or with only soft tissue recurrences, whereas CEA and alkaline phosphatase levels were significantly elevated (peripheral blood lymphocyte count, total protein and albumin levels significantly decreased) in patients with recurrent disease of all sites. Among patients with disseminated breast cancer and normal CEA levels, about 50% had markedly elevated Sialtx activities. From our limited experience, it appears that Sialtx study is of value when CEA failed to indicate the presence of breast malignancy. Further testing including serial studies should be done to better define its clinical usefulness.
Serum immunoglobulins in colorectal cancer
Authors: Slater Gary , Papatestas Angelos E. , Shafir Michail , Aufses Arthur H. 
Published: February 2007

AbstractPreoperative serum immunoglobulins were measured in 102 patients with colorectal carcinoma. There were no differences in the mean values of IgA, IgM or IgG between stages. There was an association, however, between advanced stage of disease and a combination of low levels of IgA (≤200 mg/dl) or high levels of IgM (≥125 mg/dl). The ratio of IgA/IgM was also found to be lower in advanced disease. It was felt that low levels of IgA and high IgM may represent an altered immune response and thus be a prognostic indicator.
Cloacogenic carcinoma of the anus
Authors: Slutzki S. , Reif R. , Bogokowsky H. 
Published: February 2007

AbstractA case is presented of transitional‐cell cloacogenic carcinoma – a rare variant of anal canal malignancy that occurred in a 58‐year‐old woman. The characteristics of this tumor are discussed, and her prognosis after abdominoperineal resection and posterior colpectomy seems good.
Effect of triiodothyronine and reserpine on induction and growth of mammary tumors in rats by 3‐methylcholanthrene
Authors: Gerard Serge St. , Gardner Bernard , Patti Joseph , Husain Vafarul , Shouten Jeffrey , Alfonso Antonio E. 
Published: February 2007

AbstractThis study was designed to investigate the effects of exogenous L‐triiodothyronine (LT3) and reserpine administration on the induction and stimulation of 3‐methylcholanthrene (3‐MC) mammary tumors. Two hundred‐fifty‐eight 30‐day‐old virgin 100 gm Sprague Dawley rats were divided into eight groups. Groups I–IV received either reserpine, LT3, both, or saline 22 days after tumor induction with 3‐MC. Groups V–VIII were pretreated with either reserpine, LT3, or both for 29 days prior to tumor induction, and treatment was continued after tumor induction in all except Group VII. All rats were observed for tumor growth and sacrificed at seven months. Reserpine administration resulted in a protective effect against tumor induction in all groups in which it was used, with the most striking effects observed in the pretreated groups. Early LT3 stimulation of tumor formation was reversed by simultaneous administration of reserpine. Prolonged administration was unnecessary when both agents were administered prior to 3‐methylcholanthrene.
Serological evaluation of human brain tumors using a microradioisotopic staphylococcal protein a assay
Authors: Cohen Alfred M. , Wood William C. 
Published: February 2007

AbstractA microradioisotopic staphylococcal protein A assay was applied to the serological evaluation of preoperative sera from brain tumor patients. The assay was performed in Terasaki plates, and a stainless steel punch and multiholed die facilitated sample prearation. Using allogeneic astrocytoma target cells, 15/19 of the brain tumor patients' sera were reactive, compared to 1/21 controls. 0/7 nonmalignant brain disease patients' sera were positve, and 5/20 sera from patients with epithelial malignancies. The brain tumor sera were not reactive against a rectal cancer cell line.
Intestinal fistula following pelvic exenterative surgery: Predisposing causes and treatment
Authors: Devereux Dennis F. , Sears Henry F. , Ketcham Alfred S. 
Published: February 2007

AbstractAn intestinal fistula is a life‐threatening complication when associated with the treatment of pelvic cancer. Such fistulae arise in 10% of patients treated by the combination of aggressive surgery and radiation therapy. Nineteen such occurrences developing in 245 patients who had pelvic exenterations are used to demonstrate the need for directing immediate attention toward correcting the physiologic and metabolic abnormalities created by the fistulae. Local control of the fistulae is facilitated by techniques for identifying its cause and precise location.
Biological markers in breast carcinoma—clinical correlations with pseudouridine, n2,N2‐dimethylguanosine, and 1‐methylinosine
Authors: Tormey Douglass C. , Waalkes T. Phillip , Gehrke Charles W. 
Published: February 2007

AbstractUrinary levels of the minor nucleosides, pseudouridine (Ψ), N2, N2‐dimethylguanosine (m22G), and 1‐methylinosine (m1I), were investigated in patients with breast carcinoma. Elevated levels of Ψ were observed in 27/131 (20.6%) patients with metastatic disease, 1/14 (7.1%) preoperative patients, and 1/28 (3.6%) postoperative N+ patients. Elevated levels of m22G and M1I were observed, respectively, in 46/131 (35.1%) and 27/131 (20.6%) patients with metastatic disease, 3/14 (21.4%), and 0/14 preoperative patients, and 6/28 (21.4%) and 2/28 (7.1%) postoperative N+ patients. There was no correlation between nucleoside levels and involvement of specific organ sites with metastatic disease, nor with chemotherapy response rate or time to treatment failure. During the treatment of metastatic disease there was a tendency for elevated pretherapy Ψ levels to decrease with attainment of a response and, if the levels subsequently rose, to be associated with treatment failure. However, increasing levels of m22G and m1I occurred with both response and disease progression. These results suggest that routine measurement of the level of the urinary nucleosides would be of limited value for following the disease course in patients with breast cancer.
Value of serial CEA determinations in a surgical adjuvant trial of colorectal and gastric carcinoma
Authors: N‐ Lim Christopher H. , McPherson T. Alexander , McClelland Allan R. , McCoy Linda , Koch Maria 
Published: February 2007

AbstractAt the Cross Cancer Institute in Edmonton, a concurrently controlled, randomized, prospective surgical adjuvant trial involving Dukes' B2 and C colorectal carcinoma and gastric carcinoma (T1‐4, N0‐2, M0) has been activated for the last two years. To date, a total of 150 patients have been entered into the three arms of the trial (namely control, immunotherapy, and chemo‐immunotherapy). Of these, 127 cases are colorectal carcinoma and 28 are gastric cancer. As part of the protocol, serial CEA determinations are obtained in all patients on a regular three‐monthly basis.So far, 28 patients have confirmed recurrence (colorectal 20, gastric 8) demonstrated clinically or radiologically. Out of these 28 patients, 25 (89.2%) had CEA > 2.5 ng/ml months before actual demonstration of recurrence. However, if one uses a cutoff of 5.0 ng/ml as significant, that is, one standard deviation from the usual accepted value, then 21 out of 28 (75%) had persistent, elevated CEA's months before the recurrence manifested itself clinically or radiologically.The CEA profiles of three representative cases from each arm of the adjuvant trial are included. It is suggested that serial CEA determinations will be an invaluable adjunctive test in following patients in an adjuvant trial setting.
Pleomorphic adenoma of the human breast
Authors: Makek Miroslav , Von Hochstetter Arthur R. 
Published: February 2007

AbstractPleomorphic adenomas of the human breast are histologically identical to those of salivary glands. To date, the literature reports but 15 such benign tumors, all of which occurred in women. The present paper describes clinical and pathologic findings in three further cases, including one man. Considered together, unnecessary mastectomy occurred in 44.4%, indicating the importance of separating this benign entity from malignancies with stromal metaplasia. In case of examination by frozen section, a peripheral portion, if not the entire tumor, should be submitted to the pathologist.
Radiation‐associated thyroid carcinoma
Authors: Razack Mohamed S. , Sako Kumao , Shimaoka Katsutaro , Getaz E. Paul , Rao Uma , Parthasarathy K. L. 
Published: February 2007

AbstractSince February, 1977, 735 patients having a history of receiving radiation therapy for benign conditions of the head and neck areas during infancy and childhood were examined in a thyroid screening program, and 159 patients were found to have palpable thyroid nodules. These patients had thyroid function tests and indirect laryngoscopy and were followed closely on suppression therapy consisting of either Cytomel or thyroid extract. Thyroidectomy was advised in those in whom the nodules persisted or increased in size. This study documents the incidence of carcinoma and other benign pathological changes and postoperative complications in this group of patients.So far, 49 patients had either a lobectomy with isthmusectomy or a total thyroidectomy. Eleven patients were found to have carcinoma (six had papillary, four had mixed papillary and follicular, and one had follicular carcinoma). Three patients had a therapeutic modified neck dissection following the documentation of microscopic involvement of paratracheal lymph nodes. A high incidence of chronic nonspecific thyroiditis, postradiation fibrosis, and follicular adenomas were also found in these patients.Three patients had temporary hypocalcemia (two weeks) and none had wound infection, hematoma, or postoperative nerve palsy. Of patients who had surgical resection, 22.4% showed thyroid carcinoma.
Metastatic carcinoma in axillary lymph nodes without pathologic evidence of a primary mammary lesion: A case report
Authors: Honoré Louis H. 
Published: February 2007

AbstractA 56‐year‐old nullipara presented with a mass in the right axilla. Pathologically, two enlarged lymph nodes were found to contain metastatic adenocarcinoma consistent with a primary from the breast. Clinically, no breast mass was palpable, and xeromammography showed diffuse ductal hyperplasia and a small focus suggestive of malignancy. Modified radical mastectomy was done, and no tumor was found pathologically in the excised breast. The patient received local radiotherapy and is alive and well one year postoperatively. Attention is drawn to this rare occurrence, and patient management is briefly discussed.
Renal carcinoma — unusual presentation and angiographic findings
Authors: Shenoy Sadashiv S. , Satchidanand Sateesh , Culver Gordon J. , Malin Barry T. 
Published: February 2007

AbstractA case of papillary renal cell carcinoma with clinical and angiographic features of an abscess is reported. Papillary renal carcinomas constitute 14% of renal adenocarcinomas. These tumors have slower growth rate and better prognosis.
Retroperitoneal sarcoma treated by surgery
Authors: Bengmark Stig , Hafström Larsolof , Jönsson Per‐Ebbe , Karp Wilhelm , Nordgren Hans 
Published: February 2007

AbstractA retrospective analysis of extensive surgery with resection of retroperitoneal sarcoma and total or partial resection of adjacent organs in 15 patients is presented. Dominating symptoms were a palpable mass (80%). The tumor was felt in all patients. In 9 of 10 patients, ultrasonography showed a solid tumor with retroperitoneal location. In 14 patients (93%) the tumor was removed, in 11 of them adjacent organs also. Five of the patients were subjected to more than one operation because of tumor recurrence. Two patients died postoperatively. Six patients are alive without tumor recurrence; and three, with recurrence 18 to 62 months after the first operation. Four patients died 5–24 months after primary operation. In seven patients (50%), the tumor recurred locally. Surgery for recurrent tumor was beneficial.Complete surgical removal provides the most effective therapeutic approach. Routine second‐look operation within a year after primary surgery may be a way to improve the results. Adjuvant cytostatic therapy could be considered.
Specific and aspecific immune responsiveness in lung cancer patients: Cutaneous delayed hypersensitivity reactions to a lung cancer‐associated antigen
Authors: Sega Ercole , Mottolese Marcella , Cordiali‐Fei Paola , Citro Gennaro , Colizza Sergio , Alcione Annamaria , Paola Manolo Di 
Published: February 2007

AbstractThe ability of a lung cancer‐associated antigen (LCAA) to provoke specific cutaneous delayed‐hypersensitivity reactions has been studied on a group of 59 lung cancer patients. Biological activity of LCAA, monitored by skin testing, was demonstrated in 32% (17 of 53) of lung cancer patients, in 48.0% with limited disease, and in 17.2% with extensive disease.All the responders were in the group of normal reactors to standard recall antigens, if three antigens were used (PPDSK‐SD, candida). No correlation was found between biological activity of LCAA and level of immunocompetence evaluated by lymphocyte‐blastic transformation with PHA and count of rosette E‐forming cells.These studies on the capacity to evoke specific DTH reactions in lung‐cancer patients will be extended to the use of assays in vitro in the perspective of a more significant evaluation of immunocompetence levels.
An animal model system for the immunotherapy of lung carcinoma using sensitized lymphocytes: A preliminary study
Authors: Marabella Patrick C. , Takada Mitsuru , Takita Hiroshi 
Published: February 2007

AbstractAn animal model system was established for immunotherapy of lung cancer using line‐1 lung carcinoma in Balb/cR mice and xenogeneic lymphocytes from New Zealand white (N2W) rabbits. The immunization schedule consisted of footpad and subcutaneous injections of 1 × 108 viable line‐1 cells into two rabbits, twice at a weekly interval. Two other rabbits were maintained as source of unsensitized lymphocytes. All rabbits were bled on day 14 at which time 45 mice were divided into three groups of 15 for both transplantation of 1 × 104 viable line‐1 cell (subcutaneously) and treatment with 1) control saline, 2) 2.5 × 106 unsensitized lymphocytes, and 3) 2.5 × 106 sensitized lymphocytes. These treatments were repeated twice at weekly intervals. Results were evaluated four weeks after transplant and initial treatment. Tumor developed in 13/15 control mice, 15/15 treated with unsensitized lymphocytes, and 7/15 with sensitized‐lymphocyte injection. The mean tumor weight for group 1 (control mice) was 1.38 ± 0.22 gm (SEM), group 2 was 2.09 ± 0.25 gm, and 0.56 ± 0.28 gm for group 3. There was a statistically significant difference between control and group 3 for both tumor appearance (P = 0.014) and tumor weight (P = 0.026).
Ultrastructural study of myoepithelial cells in breast carcinoma
Authors: Ghosh Luna 
Published: February 2007

AbstractThis investigation was designed to study the myoepithelum of the human mammary carcinoma. Tissues were obtained from 30 infiltrating ductal carcinomas. Under light microscope, there were no significant changes noted in the myoepithelium. Glutaraldehyde‐fixed tissues were examined under electron microscope. In infiltrating carcinoma the myoepithelial cells contained increased endoplasmic reticulum, abundant microfilaments, secretory granules and intracytoplasmic duct formation. This observation suggests that myoepithelium takes an important and active role in the infiltrating stage of the human mammary carcinoma.