bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk of Alzheimer's Disease in People with Diabetes Mellitus
Authors: Tunio Abdul Raheem , Batool Shafaque , Khan Muhammad Umer Zaheer , Samo Ufaque Batool K. , Saldera Kausar Abbas , Lakho Rizwan , arshad Jehan zaib 
Published: March 2024

Abstract
Background
Diabetes mellitus (DM) may increase the risk of Alzheimer dementia (AD) in a number of biologically conceivable ways, although it is still uncertain how DM and the development of AD are related.
Objective
To assess the risk of AD in subjects with and without DM.
Design:
Prospective community-based cohort study.
Participants:
Framingham Research Participants (n = 2210; 1325 women; mean age, 70 years) who were part of the first cohort and did not have dementia and participated in the biennial test.
Main Outcome Measures:
Relative risk of incident Alzheimer disease within the overall group and within subgroups defined by plasma homocysteine levels and apolipoprotein E genotype (based on criteria from the National Institute of Neurological and Communicative Diseases and Stroke/Association for Alzheimer’s Disease and Related Disorders); models were adjusted for age, sex, and cardiovascular risk factors.
Results
At baseline, 202 people (9.1%) in total had DM. During the follow-up period (mean, 12.7 years; range, 1–20 years), the development of AD created a relative risk of 1.15 (95% confidence interval, 0.65–2.05) in 17 of 202 persons with diabetes (8.1%) and 220 of 2008 people without diabetes (11.0%). Of the 684 participants, 44 (6.4%) did not have elevated plasma homocysteine levels or an apolipoprotein E 4 allele; the relative risk of AD was 2.98 (95% confidence range, 1.06–8.39; P = .03) in patients with diabetes compared to those without diabetes. The effect was greatest among individuals 75 years of age or older, with a relative risk of 4.77 (95% confidence interval, 1.28–17.72; P = .02).
Conclusion
Overall, diabetes mellitus did not increase the incidence of incident AD in the Framingham cohort; however, in the absence of other major risk factors for AD that are known to exist, diabetes mellitus may be a risk factor for AD.
Dinâmica para formação docente no planejamento de ensino estruturado para projeto integrador
Authors: Veraldo Júnior Lucio Garcia , Marins Fernando Augusto Silva 
Published: March 2024

A formação docente desempenha um papel fundamental na capacitação de professores para o planejamento de ensino estruturado em projetos integradores. O ensino estruturado é uma abordagem pedagógica que busca organizar o conteúdo de forma clara e sequencial, promovendo a aprendizagem significativa dos alunos. No contexto do projeto integrador, os professores são responsáveis por elaborar um plano de ensino que integre diferentes disciplinas ou áreas do conhecimento, proporcionando uma visão holística e interdisciplinar aos estudantes. O objetivo geral deste trabalho é estabelecer o conjunto de atividades a serem desenvolvidas no projeto integrador utilizando o método 30-60-10. A formação proposta para o desenvolvimento do plano de ensino estruturado referente ao projeto utilizou o método World Café. A formação docente no planejamento de ensino estruturado para projetos integradores deve ser contínua e atualizada, considerando as mudanças no campo da educação e as demandas da sociedade contemporânea.
Effect of aging process on precipitated phase and properties of mechanical extruded aluminum alloy
Authors: Zhang Honggang , Chen Rui , Gu Xiaomei 
Published: March 2024

As the industrial sector develops, the performance requirements for aluminum alloys are also constantly improving. The study explores how aging and rolling treatment affect aluminum alloys' precipitates and mechanical properties by controlling the parameters of aging process and rolling deformation variables. 7N01 aluminum alloy was selected as the experimental object, and the samples were treated with non-aging, natural aging, artificial aging, and rolling deformation. How aging processes and rolling deforming affected alloys’ mechanical properties was evaluated through performance testing (mechanical and tensile testing) and material fiber characterization methods (advanced electronic instruments). These results confirmed that the combination of three aging pre-treatments + R20 % + 120 °C re-aging could significantly improve the hardness of aluminum alloys and maintain high ductility. As the deformation decreased, the time for the sample to reach the hardness peak was shorter and the hardness was higher. The 20 % deformation sample’s strength was better than the 80 % deformation sample’s. This confirmed that appropriate aging process and deformation combinations could improve the strength and hardness of aluminum alloys. These results have certain guiding significance for optimizing the aging process of mechanical extruded aluminum alloys and provide reference for the study of related alloy properties.
Epithelioid Mesothelioma of Peritoneum Masquerading as Peritoneal
Carcinomatosis
Authors: Bharti Jyotsna Naresh 
Published: March 2024

Introduction::
Mesothelioma is an insidious neoplasm that develops from mesothelial cells. About 80% of mesotheliomas originate in the pleural cavity. Other
sites where it has been reported are the peritoneal cavity, tunica vaginalis, and the pericardium.

Case Presentation::
A 45-year-old female complained of abdominal distention and pain for three months. There was a significant weight loss of approximately 15 kg in
the past three months, and there was no family history of any malignancy, tuberculosis, substance abuse, or asbestosis exposure. Physical
examination revealed signs of muscle wasting, loss of subcutaneous fat, and hollowing of the eye sockets. There was pitting edema in the bilateral
lower limbs; per abdomen examination revealed abdominal distension with umbilicus in the midline. No visible peristalsis or dilated veins were
seen all over the abdomen. Hernial sites were normal. Gross ascites were present, and no organomegaly, definitive mass, or lump was palpable.
The dull note was heard all over the abdomen, and fluid thrill was noted on percussion. Bowel sounds were normal on auscultation. The ascitic
fluid examination revealed the presence of atypical cells. An omentectomy was done and it was sent for histopathological examination.

Conclusion::
The specimen of omentectomy was in multiple fragments and measured 17x16x3cm; a few of the fragments were nodular, soft to firm on
palpation. The cut section of mass was gray and white with areas of necrosis. Microscopic examination showed sheets of malignant cells. These
tumor cells were immunoreactive to EMA, cytokeratin, vimentin, calretinin, WT-1, and D2-40 and immune negative to desmin (highlighting only
the entrapped reactive mesothelial cells), inhibin, BerEP4, TTF-1, CD 68, napsin, ER, CEA, CDX2, PR, PAX-8, and SALL4. Ki67 labelling index
was 15%. The features were of epithelioid mesothelioma.
A Study on the Anti-inflammatory Activity of Clematis tangutica Using
Molecular Networking
Authors: Li Aijing , Chen Tao , Wang Shuo , Luo Juyuan , Shen Cheng , Li Hongmei , Ma Yumei , Song Zhibo , Lu Weihang , Zou Denglang , Li Yulin 
Published: March 2024

Background::
Clematis tangutica, an indigenous medicinal herb native to the Qinghai-
Tibet Plateau of China, has traditionally been associated with treating various inflammation-related
diseases. While its therapeutic potential is recognized, a comprehensive characterization of its metabolite
molecules and their anti-inflammatory properties has not been undertaken.

Objective::
This study aimed to comprehensively profile the metabolite molecules of Clematis tangutica
and identify potential anti-inflammatory active molecules using the Activity Labelled Molecular
Networking (ALMN) approach.

Methods::
The ALMN approach was employed to visually label activity to the feature-based molecular
network, allowing for the profiling of potential anti-inflammatory active molecules in Clematis
tangutica. Through correlating activity levels with the respective molecules, a detailed profiling was
achieved.

Results::
Out of the 8,644 metabolite molecules in Clematis tangutica, ten were identified as the most
potent anti-inflammatory molecules. Among these, Spiraeoside was notably annotated along with its
structure.

Conclusion::
This research successfully identified ten potent anti-inflammatory molecules from the
vast metabolite profile of Clematis tangutica, including a detailed annotation of Spiraeoside. This
marked a significant step in bridging traditional therapeutic knowledge with modern molecular profiling
techniques.
Automated Synthesis of [11C]PiB via [11CH3OTf]-as Methylating Agent for
PET Imaging of β-Amyloid
Authors: Singh Akhilesh K. , Gambhir Sanjay , Dixit Manish 
Published: March 2024

Aim::
Efficient synthesis of precursor from commercially available starting materials
and automated radiosynthesis of [11C]PiB using commercially available dedicated [11C]-
Chemistry module from the synthesized precursor.

Background::
[11C]PiB is a promising radiotracer for PET imaging of β-Amyloid,
advancing Alzheimer's disease research. The availability of precursors and protocols
for efficient radiolabelling foster the applications of any radiotracer. Efficient synthesis
of PiB precursor was performed using anisidine and 4-nitrobenzoyl chloride as starting
materials in 5 steps, having addition, substitutions, and cyclization chemical methodologies.
This precursor was used for fully automated radiosynthesis of [11C]PiB in a commercially
available synthesizer, MPS-100 (SHI, Japan). The synthesized [11C]PiB was purified via
solid-phase methodology, and its quality control was performed by the quality and safety criteria
required for clinical use.

Methods::
The synthesis of desired precursors and standard authentic compounds started
with commercially available materials with 70-80% yields. The standard analytical methods
were characterized all synthesized compounds. The fully automated [11C]-chemistry synthesizer
(MPS-100) used for radiosynthesis of [11C]PiB with [11C]CH3OTf acts as a methylating agent.
For radiolabelling, varied amounts of precursor and time of reaction were explored. The resulting
crude product underwent purification through solid-phase cartridges. The synthesized radiotracer
was analyzed using analytical tools such as radio TLC, HPLC, pH endo-toxicity, and
half-life.

Results::
The precursor for radiosynthesis of [11C]PiB was achieved in excellent yield using
simple and feasible chemistry. A protocol for radiolabelling of precursor to synthesized
[11C]PiB was developed using an automated synthesizer. The crude radiotracer was purified by
solid-phase cartridge, with a decay-corrected radiochemical yield of 40±5% and radiochemical
purity of more than 97% in approx 20 minutes (EOB). The specific activity was calculated and
found in a 110-121 mCi/μmol range.

Conclusion::
A reliable methodology was developed for preparing precursor followed by
fully automated radiolabeling using [11C]MeOTf as a methylating agent to synthesize
[11C]PiB. The final HPLC-free purification yielded more than 97% radiochemical purity
tracer within one radionuclide half-life. The method was reproducible and efficient for any
clinical center.
Traumatic Brain Injury: Current Trends Towards the Increase of the Number of Cases and Its Diagnosis
Authors: Kozan Nataliia , Dunaiev Oleksandr 
Published: March 2024

Introduction The global medical community calls traumatic brain injury (TBI) a "silent epidemic" because the latter causes a significant increase in mortality and disability more than any other mechanical injury. Although today's world achievements demonstrate powerful technical capabilities for accurate diagnosis of the time of occurrence and mechanism of TBI, however, the commission examination departments of the forensic medical examination bureau are considering more and more cases of diagnostic errors made by forensic medical experts during autopsies , which later caused protracted legal proceedings.
Aim. In this study, we aimed to evaluate the modern diagnostic possibilities of methods for verifying the diagnosis and the time formation of TBI.
Methods. Literary data on the prevalence and methods of diagnosing TBI at the present time were analyzed.
Results. The degree and severity of TBI, as well as its course, after the initial mechanical injury depends on many factors. In the last decade, there has been an intensification of research on protein biomarkers based on biofluids (blood, cerebrospinal fluid) for intravitality diagnosis. However, not all markers provide reliable information that would correlate with the presence of TBI. Until now, the "gold standard" of diagnosis is an autopsy, next to which radiological studies are effectively used.
Conclusion.
Taking into account the global statistical data, postmortem diagnosis of TBI is an important issue of forensic traumatology, which requires a careful approach.
Generation Z’s Health Information Avoidance Behavior: Insights From Focus Group Discussions
Authors: Jia Chenjin , Li Pengcheng 
Published: March 2024

Background
Younger generations actively use social media to access health information. However, research shows that they also avoid obtaining health information online at times when confronted with uncertainty.

Objective
This study aims to examine the phenomenon of health information avoidance among Generation Z, a representative cohort of active web users in this era.

Methods
Drawing on the planned risk information avoidance model, we adopted a qualitative approach to explore the factors related to information avoidance within the context of health and risk communication. The researchers recruited 38 participants aged 16 to 25 years for the focus group discussion sessions.

Results
In this study, we sought to perform a deductive qualitative analysis of the focus group interview content with open, focused, and theoretical coding. Our findings support several key components of the planned risk information avoidance model while highlighting the underlying influence of cognition on emotions. Specifically, socioculturally, group identity and social norms among peers lead some to avoid health information. Cognitively, mixed levels of risk perception, conflicting values, information overload, and low credibility of information sources elicited their information avoidance behaviors. Affectively, negative emotions such as anxiety, frustration, and the desire to stay positive contributed to avoidance.

Conclusions
This study has implications for understanding young users’ information avoidance behaviors in both academia and practice.
PERBEDAAN ORGANIZATIONAL CITIZENSHIP BEHAVIOR (OCB) PADA PEGAWAI DENGAN TIPE KEPRIBADIAN A DAN B
Authors: Hendarto Veldinor Dwi 
Published: March 2024

Karyawan yang bekerja di bidang industri mempunyai job description yang berbeda – beda. Perilaku yang mengarah pada organizational citizenship behavior (OCB) akan muncul tergantung dari insiatif masing – masing karyawan dalam membantu rekan kerjanya. Karyawan yang berperilaku OCB mempunyai dampak positif untuk keefektifan perusahaan dalam menghasilkan produksi yang berkualitas. Salah satu faktor yang dapat memunculkan perilaku OCB ialah faktor kepribadian.Tujuan dari penelitian ini ialah untuk mengetahui perbedaan Organizational Citizenship Behavior (OCB) ditinjau pada karakteristik kepribadian. Penelitian ini menggunakan skala kepribadian dengan model skala Guttman dan Skala Organizational Citizenship Behavior dengan model skala Likert. Jumlah subjek dalam penelitian ini sejumlah 134 dengan status karyawan tetap. Hasil dalam penelitian ini menunjukkan ada perbedaan Organizational Citizenship Behavior antara tipe kepribadian A dan B (t = 3.910; p = 0.000). Kata kunci: Organizational citizenship behavior, karyawan, kepribadian The employees who work in the industry has a different job description. The behavior of OCB will appear depending on the initiative of the employees to help his co-workers. Theemployees who behave OCB has a positive impact on the effectiveness of the company in the production of high quality produce.One of the factors that can bring OCB are personality factors. The purpose of this study was to determine differences in Organizational Citizenship Behavior reviewed the characteristics of personality.One of the factors that can influence the behavior of OCB are personality factors. The purpose of this study was to determine differences in Organizational Citizenship Behavior reviewed the characteristics of personality.This study used a non-test method is by using a scale model of personality with the Guttman scale and Organizational Citizenship Behavior Scale with Likert scale models. The number of the subject of as much as 134 people with the status of permanent employees an age range of 25-50 years.The results of this study showed that there are differences in Organizational Citizenship Behavior, between personality types A and B is evidenced by test of the t-test that obtain (t=3.910 ; p=0.000). Keywords: Oganizational citizenship behavior, employee, personality.
GAGAL JANTUNG DEKOMPENSASI AKUT DISERTAI DENGAN SINDROM KORONER AKUT : LAPORAN KASUS
Authors: Mahendra Mardaningrat Gede Ari 
Published: March 2024

Abstrak
Gagal jantung adalah penyebab utama rawat inap di dunia. Pasien yang dirawat di rumah sakit dengan gagal jantung dekompensasi akut (ADHF) menghadapi risiko besar kematian di rumah sakit dan mengalami rawat inap kembali. Kami di sini melaporkan kasus gagal jantung dekompensasi akut yang disertai dengan sindrom koroner akut. Seorang pasien laki-laki berusia 80 tahun dibawa ke UGD dengan keluhan sesak napas, nyeri dada dan bengkak pada kedua kaki. Pasien memiliki riwayat rawat inap karena penyakit jantung 6 bulan yang lalu. Saat ini pasien mengkonsumsi obat-obatan furosemide 1x40 mg, aspilet 1x80 mg, spironolactone 1x25 mg, bisoprolol 1x2.5 mg, uperio 2x50 mg. Pasien juga mempunyai riwayat diabetes melitus sejak 3 tahun dengan pengobatan insulin reyzodeg 2x10 unit. Pemeriksaan fisik ditemukan batas jantung yang melebar mengesankan kardiomegali, suara ronki di kedua lapang paru dan pitting edema pada pemeriksaan kedua kaki pasien.EKG menunjukkan adanya gambaran infark lama pada jantung di bagian anterior ekstensif. Rontgen dada menunjukkan adanya pembesaran jantung disertai dengan edema paru. Pasien diberikan terapi oksigen nasal kanul 4 liter per menit, aspilet 80 mg, clopidogrel 75 mg,v-blok 3,125 mg, atorvastatin 20 mg, furosemid 20 mg, candesartan 8 mg. Penatalaksanaan penyakit gagal jantung dekompensasi akut disertai dengan adanya komorbid DM harus dikelola sesuai dengan rencana perawatan dan pengobatan yang baik untuk menghindari pasien berada di kondisi yang lebih parah.

Kata kunci: Gagal Jantung, Diabetes Mellitus
LAPORAN KASUS: KATARAK SENILIS MATUR DENGAN RIWAYAT DIABETES MELITUS DAN HIPERTENSI
Authors: Mahaswari Ni Putu Radha Kharisma Mahaswari , Ni Nyoman Sekarsari  , Ni Kadek Sri Emi Lyana  , Komang Hendra Setiawan  
Published: March 2024

Abstrak
Katarak adalah pengaburan lensa kristal intraokular alami yang memfokuskan cahaya yang masuk ke mata ke retina. Katarak adalah penyakit yang progresif secara bertahap dan merupakan penyebab utama kebutaan di seluruh dunia. Pada tahun 2014-2016, menunjukkan bahwa prevalensi kebutaan di lndonesia mencapai 30%, dengan penyebab utama gangguan penglihatan dan kebutaan adalah katarak. Faktor risiko meningkatkan kejadian katarak berupa diabetes melitus dan hipertensi. Kedua hal tersebut menyebabkan perubahan struktur konformasi protein pada kapsul lensa. Pada pemeriksaan fisik didapatkan status oftalmologi pasien pada okuli dekstra dengan visus hand movement, lensa keruh, iris shadow (-), dan reflex fundus (-), dengan tekanan intaokular 17.3 mmHg. Okuli sinistra dengan visus 2/60, iris shadow (+), dan reflex fundus (+). Pemeriksaan gula darah acak didapatkan 125 mg/dl. Tatalaksana yang dapat dilakukan berupa fakoemulsifikasi dan SICS (small incision cataract surgery) dengan memberikan hasil yang baik dengan biaya yang murah dan singkat.
Kata Kunci: Katarak senilis matur, diabetes, hipertensi
Abstract
A cataract is a clouding of the natural intraocular crystalline lens that focuses the light entering the eye onto the retina. Cataract is a gradually progressive disease and is the leading cause of blindness worldwide. In 2014-2016, In 2014-2016, the prevalence of blindness in Indonesia reached 30%, with the main cause of visual impairment and blindness being cataracts. Risk factors for increasing cataract incidence include diabetes mellitus and hypertension. Both cause changes in the protein conformational structure of the lens capsule. On physical examination, the patient's ophthalmological status was found to be in the right eye with hand movement vision, cloudy lens, iris shadow (-), and fundus reflex (-), with an intraocular pressure of 17.3 mmHg. Left oculi with visual acuity 2/60, iris shadow (+), and fundus reflex (+). A random blood sugar check showed 125 mg/dl. Management can be done in the form of phacoemulsification and SICS (small incision cataract surgery) with good results at a low cost and short time.
Keywords: Mature senile cataract, diabetes, hypertension
KEWENANGAN HUKUM ADMINISTRASI TERKAIT PENYALAHGUNAAN WEWENANG DALAM TINDAK PIDANA KORUPSI DI INDONESIA
Authors: Maya Alya , W Kresnha Adhy 
Published: March 2024

Penelitian ini bertujuan untuk mengetahui hubungan hukum adminstrasi dengan permasalahan tindak pidana korupsi di indonesia serta mengetahui mengenai unsur penyalahgunaan wewenang dalam tindak pidana korupsi merupakan kompetensi absolut dalam peradilan administrasi. Jenis penelitian yang digunakan adalah yuridis normatif. Sedangkan pendekatan yang digunakan adalah pendekatan perundang-undangan. Hasil penelitian menujukan bahwa hubungan antara hukum pidana dengan hukum acara administrasi tidak hanya terkait tindak pidana korupsi melainkan juga terkait dengan Keuangan Negara, perbendaharaan negara serta mengenai badan pemeriksa keuangan (BPK). Hasil penelitian ini juga menunjukkan bahwa kewenangan untuk memeriksa dan memutus unsur penyalahgunaan wewenangan dalam tindak pidana korupsi merupakan kompetensi absolut dari peradilan administrasi, dikarenakan secara konsep “penyalahgunaan wewenang” berdasarkan Undang-Undang Administrasi Pemerintahan dan konsep “menyalahgunakan kewenangan” dalam Undang-Undang Pemberantasan Tindak Pidana Korupsi secara teoritis dan praktis merupakan konsep yang sama.