bluuebunny/crossref_metadata_2025_split huggingface dataset:
Atrial fibrillation in coronary artery disease patients: gut microbiota composition and echocardiography indexes
Authors: Melnychuk Iryna , Sharayeva Maryna 
Published: February 2024

The aim: to find connections between gut microbiota composition and transthoracic echocardiography (TTE) indexes in patients with coronary artery disease (CAD) and atrial fibrillation (AF).
Materials and methods: 300 patients were divided into 3 groups: first (CAD) – 149 patients with CAD but without arrhythmias; second (CAD+AF) – 124 patients with CAD and AF paroxysm; and the control group – 27 patients without CAD and arrhythmias. 16-S rRNA sequencing checked gut microbiota composition. TTE was done by ALOKA SSD-5000.
Results: The II group patients were characterized by the increase of LAD (10.03 %), LAV (15.40 %) and LAVI (11.48 %) in comparison with the I group, P<0.05. The II group patients were characterized by a rise of Pseudomonadota in comparison with the I group, P<0.05. Also, II group patients were characterized by rise of Actinobacter Spp. and decrease of Blautia Spp., Bacteroides Thetaiotaomicron in comparison with the I group, P<0.05. Firmicutes were correlated with AO (r=0.308), LADI (r=-0.363), RV (r=-0.470), IVS (r=-0.381), LVPW (r=-0.345), LVM (r=-0.476) and EF (r=0,312), P<0.05. Akkermansia Muciniphila was correlated with LAD (r=-0.343), LADI (r=-0.308), LAV (r=-0.494), LAVI (r=-0.488), RAV (r=-0.316), RAVI (r=-0.397), RV (r=-0.383), EF (r=0.332), P<0.05. Bifidobacterium Spp. were correlated with LAV (r=-0.487), LAVI (r=-0.327), RV (r=-0.341), IVS (r=-0.306), RWT (r=-0.389), LVM (r=-0.369), LVMI (r=-0.312), EF (r=0.317), P<0.05. Streptococcus Spp. were correlated with AO (r=0,329), LVOT (r=0,390), RV (r=0,393), IVS (r=0,648), LVPW (r=0,579), RWT (r=0,356), LVM (r=0,336), LVMI (r=0,376), P<0.05. Ruminococcus Spp. were correlated with AO (r=0,412), LVOT (r=0,351), LADI (r=-0.343), IVS (r=-0.316), LVPW (r=-0.367), LVM (r=-0.302), LVMI (r=-0.379), P<0.05.
Conclusion: Gut microbiota composition and TTE indexes play a significant role in CAD and AF pathogenesis. Firmicutes, Bifidobacterium spp., and Verrucomicrobiota (Akkermansia muciniphila) were significantly correlated with left atrium size and volume, as well as their ultrasound indexes. Bifidobacterium spp., Bacteroides Spp., Streptococcus Spp. and Ruminococcus Spp. were significantly correlated with left ventricular sizes and its hypertrophy indexes
ANÁLISIS DE LA MATRÍCULA EN EDUCACIÓN SUPERIOR EN COLOMBIA 2017-2018
Authors: Rincón-Báez William Umar , Becerra Plaza Gisèle Eugenia , Arias-Velandia Nicolas 
Published: February 2024

En el boletín decimosexto del Observatorio de Ciencias Administrativas de ASCOLFA, presentan un análisis de la variación de matriculados en las instituciones de educación superior en Colombia entre 2017 y 2018 a partir de los datos presentados por el Ministerio de Educación Nacional en el Sistema Nacional de Información de la Educación Superior – SNIES-, donde se presentan las estadísticas. En las últimas semanas a partir de la presentación de estos datos, en Colombia se ha alertado por la caída de las matrículas a nivel nacional, pero es bueno revisar un contexto más particular, por ello este Boletín revisara algunos aspectos relevantes como el cambio por departamentos, por origen de las instituciones, por nivel de formación, especialmente el nivel universitario, por Área de formación, por metodología del programa y al final se realizara un análisis del Área de Economía, Administración, Contaduría y afines. Todos los datos se comparan entre las bases de datos de información de Matriculados de 2017 y 2018
RESULTADOS POR GRUPOS DE REFERENCIA SABER PRO 2017
Authors: Rincón Báez William Umar , Becerra Plaza Gisèle Eugenia 
Published: February 2024

El Boletín Observatorio en Ciencias Administrativas presenta los resultados de los módulos de competencias genéricas de la Prueba Saber Pro 2017, por los diferentes grupos de referencia en los que se agrupan los programas de educación superior que poseen características similares. Los resultados promedio se comparan con los resultados de 2016 y se evalúan los diferentes niveles de desempeño en cada módulo. Estas comparaciones dan un panorama general de cada grupo de referencia, dando un análisis inicial de la prueba.
MATRICULA DE POSGRADO 2018
Authors: Rincón-Báez William Umar , Becerra Plaza Gisèle Eugenia , Arias-Velandia Nicolas 
Published: February 2024

El vigésimo boletín del Observatorio de Ciencias Administrativas de ASCOLFA, se muestran los cambios en la Matrícula Total y de Primer curso de estudiantes del nivel de Posgrado entre 2017 y 2018, analizando con respecto a las características de las Instituciones de Educación Superior (IES), utilizando los datos del Sistema Nacional de Información de la Educación Superior - SNIES-1 . Se analiza la cantidad de estudiantes por nivel de formación de nivel universitario (Doctorado, Maestría, Especialización Universitaria y Especialización Médico Quirúrgica), sector (Oficial o Privado) y carácter de la IES (Universidad, Institución Universitaria/escuela tecnológica, institución tecnológica, Institución técnica profesional), Metodología del programa, área de la formación del programa y distribución de la matricula en el país. Además se realiza un análisis los núcleos de formación de los programas de Administración, Contaduría y Economía
TASA DE COTIZANTES E INGRESOS POR METODOLOGÍA, GÉNERO Y REGIONES DE GRADUADOS EN COLOMBIA (2007- 2016)
Authors: Rincón-Báez William Umar , Becerra Plaza Gisèle Eugenia , Arias-Velandia Nicolas 
Published: February 2024

En el séptimo boletín del Observatorio en Ciencias Administrativas, se analizan las cifras de tasas de cotización e ingresos de los graduados por metodología, género y diferentes regiones en que divide el Departamento Administrativo de Estadísticas (DANE) al país (agrupando en ellas a diferentes Departamentos) y que utiliza además el Observatorio Laboral para la Educación (OLE) del Ministerio de Educación Nacional, inicialmente para todas las áreas y luego para los tres núcleos básicos de Administración, Economía y Contaduría, en estas mismas variables. Para este ejercicio se utilizan los datos del OLE (Colombia. Observatorio Laboral para le Educación, 2017)1.
The Effect of Hypoxic Exercise Combined with Crocodile Blood Supplementation on Aerobic Capacity and Hematological Variables in Athletes
Authors: Thuwakum Worrawut , Manimmanakorn Apiwan , Chaeychomsri Win , Siruntawineti Jindawan , Sukjit Sasithorn 
Published: February 2024

Study purpose. This study aimed to compare the effects of hypoxic exercise combined with crocodile blood supplementation on hematological and maximum oxygen consumption parameters in soccer players.
Materials and methods. This study included 39 male soccer players aged 21.69 ± 1.98 years who were randomized to three groups. All groups performed the same training program, which comprised treadmill exercise at 70%–75% of maximum heart rate for 7 weeks with sessions of 30 min/day and 3 days per week. The first group was the control placebo group (CG, n = 13), the second group received one capsule per day (60 mg) of a freeze-dried crocodile blood supplement (SUP, n = 13), and the third group received the freeze-dried crocodile blood supplement and performed the training program under hypoxic conditions (H-SUP, n = 13, FiO2 = 16.3%). A hematological evaluation was conducted and maximal oxygen uptake (VO2max) was measured using the Bruce protocol treadmill test.
Results. The H-SUP group demonstrated significantly higher erythropoietin (EPO) levels (14.40 ± 2.41 mIU/mL) compared to the SUP group (11.50 ± 2.08 mIU/mL) and CG (12.01 mIU/mL) after the intervention. From pre- to post-intervention, VO2max significantly increased in the H-SUP (Pre: 45.63 ± 4.75, Post: 49.33 ± 5.81) and SUP groups (Pre: 44.59 ± 4.75, Post: 47.30 ± 5.68) but not in the CG.
Conclusions. This study reveals that a combination of freeze-dried crocodile blood supplementation and hypoxic exercise causes hematological alterations, particularly the activation of EPO secretion, and increases VO2max in soccer players.
Generalization of Deep-Learning Models for Classification of Local Distance Earthquakes and Explosions across Various Geologic Settings
Authors: Maguire Ross , Schmandt Brandon , Wang Ruijia , Kong Qingkai , Sanchez Pedro 
Published: February 2024

Abstract
Although accurately classifying signals from earthquakes and explosions at local distance (&lt;250 km) remains an important task for seismic network operations, the growing volume of available seismic data presents a challenge for analysts using traditional source discrimination techniques. In recent years, deep-learning models have proven effective at discriminating between low-magnitude earthquakes and explosions measured at local distances, but it is not clear how well these models are capable of generalizing across different geological settings. To address the issue of generalization between regions, we train deep-learning models (convolutional neural networks [CNNs]) on time–frequency representations (scalograms) of three-component earthquake and explosion signals from eight different regions in the continental United States. We explore scenarios where models are trained on data from all regions, individual regions, or all but one region. We find that although CNN models trained on individual regions do not necessarily generalize well across different settings, models trained on multiple regions that include diverse path coverage generalize to new regions, with station-level accuracy of up to 90% or more for data sets from unseen regions. In general, CNN-based discrimination models significantly outperform models based on uncorrected P/S ratio (measured in the 10–18 Hz frequency band), even when CNN models are tested on data from entirely unseen regions.
Pemetaan Potensi Desa Banjarejo melalui Pembuatan Masterplan Desa Berbasis Eco-Tourism
Authors: Ariestadi Dian , Ansyorie M. Musthofa Al , Alfianto Imam , Revantoro Nemesius Bambang , Ichwanto M. Aris 
Published: February 2024

Banjarejo Village is one of the Assisted Partner villages of Universitas Negeri Malang (UM) located in the administrative area of Pakis District, Malang Regency. As a lowland village, Banjarejo has significant potential for water resources, vegetable farming, and freshwater fisheries, making it an ideal rural tourist destination. The village's location on the route of community movement from Malang City to Malang Regency and vice versa, as well as its proximity to the Pakis toll exit, make it a likely pass-through point for many tourists travelling to Bromo. This objective observation is supported by the village's location. This plan should be developed with the assistance of universities, using scientific and technological expertise. Banjarejo Village has untapped potential in agriculture, animal husbandry, and other fields. To fully utilise these resources, a village potential masterplan is required. The masterplan should encompass all aspects of the village's potential.
Desa Banjarejo merupakan salah satu desa Mitra Binaan Universitas Negeri Malang (UM) yang berada dalam kawasan administratif Kecamatan Pakis Kabupaten Malang. Sebagai desa dengan wilayah dataran rendah, Desa Banjarejo memiliki banyak potensi sumber daya air, pertanian sayur, serta perikanan air tawar yang menjadikan peluang bagi Desa Banjarejo untuk berkembang menjadi destinasi wisata pedesaan. Hal tersebut didukung pula dengan lokasi desa yang berada pada jalur perpindahan masyarakat dari Kota Malang menuju Kebupaten malang dan sebaliknya, dimana dengan posisi desa yang tidak jauh dari exit tol pakis maka tidak menutup kemungkinan banyak wisatawan terutama yang berasal dari luar Malang untuk berwisata menuju Bromo dapat dipastikan melewati wilayah Desa Banjarejo ini. Beberapa potensi desa yang telah ataupun belum diketahui di Desa Banjarejo membutuhkan sentuhan IPTEKS dari perguruan tinggi untuk dibuat dalam bentuk masterplan potensi desa. Masterplan potensi desa yang dimaksud dalam hal ini adalah seluruh potensi desa baik dibidang pertanian, peternakan, dan bidang-bidang lainnya.
Incidence of hypertension and its risk factors: a systematic review
Authors: Sekhon Charan Kamal , Kaur Ramandeep , Airi Monika 
Published: February 2024

Hypertension is a persistent, metabolic condition indicated by elevated blood pressure levels. Since hypertension comes with no warning signs, mostly people are not aware of it. The aim of the study was to assess the change in the prevalence of hypertension among adults of Punjab and Haryana and to investigate its risk factors. Medline, Web of Science and Scopus databases from 2009 to 2023 were searched for ‘prevalence, burden, awareness, and control of blood pressure (BP) or hypertension (≥140 SBP and or ≥90 DBP) among Indian adults’ (≥18 years). The incidence of hypertension varied from 32.4 to 88.2 percent in male subjects and 30 to 84.7 percent in female subjects. Hypertension was more prevalent among males of Punjab and Haryana. Whereas females were more hypertensive in different districts of Haryana. The considerable upward trend has been observed over the time, among males and females in both Punjab and Haryana, yet awareness and control rates are comparatively low. Various researchers have discovered that younger the age of beginning of hypertension, the higher the decline in life expectancy if raised blood pressure is not managed.
Sensory attributes and quality perception of red natural wines: a comparative study in Spain and France
Authors: Ballester Jordi , Belascoin Mirian , Gonzalez-Hernandez Marivel , Parga-Dans Eva , Alonso González Pablo , Saenz-Navajas Maria-Pilar 
Published: February 2024

Although the definition of natural wine remains contested and still lacks official recognition, it can be broadly described as a wine made with organic or biodynamic grapes without oenological additives in the cellar and minimal intervention in all winemaking stages. Despite growing interest in natural wines, uncertainty prevails about their sensory and quality attributes among both consumers and experts. In light of this research gap, this study aims to determine, first, if there are specific sensory dimensions allowing to differentiate natural wine as a wine category from conventional wines; second, if this sensory dimension affects the perception of the quality; and third, to characterise the physicochemical differences in terms of basic oenological parameters between natural wines and their conventional counterparts. To do so, 24 red wines (12 self-defined as natural and 12 conventional wines) were sensory and chemically characterised. The sensory evaluation was first carried out by winemakers from Spain. It consisted of a descriptive task (labelled sorting task) followed by a quality evaluation under two conditions: with and without information regarding the production method. A second panel of French experts carried out the same quality assessment, also with and without information. The aim was to find out whether expectations existed linked to each type of wine and to explore potential cross-cultural effects. The results of the labelled sorting task showed that natural wines tended to be different from conventional wines, but the difference was not clear-cut. However, natural wines were perceived to be of lower quality than their conventional counterparts, both with and without the information provided, regardless of the origin of winemakers. Results of the chemical analysis showed that natural wines presented higher values for volatile and total acidity and turbidity, while they had lower values for total and free sulphur. The study points to the existence of sensory dimensions with an impact on overall quality associated with the production method.
Multimodal beneficial effects of BNN27, a Nerve Growth Factor synthetic mimetic, in the 5xFAD mouse model of Alzheimer’s Disease
Authors: Charalampopoulos Ioannis , Kokkali Maria , Karali Kanelina , Thanou Evangelia , Papadopoulou Maria , Zota Ioanna , Tsimpolis Alexandros , Efstathopoulos Paschalis , Calogeropoulou Theodora , Li Ka Wan , Sidiropoulou Kyriaki , Gravanis Achille 
Published: February 2024

Abstract

Alzheimer’s Disease (AD) is an incurable and debilitating progressive, neurodegenerative disorder which is the leading cause of dementia worldwide. Neuropathologically, AD is characterized by the accumulation of Aβ amyloid plaques in the microenvironment of brain cells and neurovascular walls, chronic neuroinflammation, resulting in neuronal and synaptic loss, myelin and axonal failure, as well as significant reduction in adult hippocampal neurogenesis. The hippocampal formation is particularly vulnerable to this degenerative process, due to early dysfunction of the cholinergic circuit. Neurotrophic factors consist major regulatory molecules and their decline in AD is considered as an important cause of disease onset and progression. Novel pharmacological approaches are targeting the downstream pathways controlled by neurotrophins, such as nerve growth factor (NGF) receptors, TrkA and p75NTR, which enhance hippocampal neurogenic capacity and neuroprotective mechanisms, and potentially counteract the neurotoxic effects of amyloid deposition. BNN27 is a non-toxic, newly developed 17-spiro-steroid analog, penetrating the blood-brain-barrier (BBB) and mimicking the neuroprotective effects of NGF, acting as selective activator of its receptors, both TrkA and p75NTR, thus promoting survival of various neuronal cell types. Our present research aims at determining whether and which aspects of the AD-related pathology, BNN27 is able to alleviate, exploring the cellular and molecular AD components and link these changes with improvements in the cognitive performance of an animal AD model, the 5xFAD mice. Our results clearly indicate that BNN27 administration significantly reduced amyloid-β load in whole brain of the animals, enhanced adult hippocampal neurogenesis, restored cholinergic function and synaptogenesis, reducing inflammatory activation and leading to significant restoration of cognitive functions. BNN27 may represent a new lead multimodal molecule with neuroprotective, neurogenic and anti-neuroinflammatory actions for developing druggable anti-Alzheimeric agents. Proteomics data are available via ProteomeXchange with the identifier PXD044699.
Slow parasite clearance, absent K13 gene polymorphisms and observation of amino-acids silent mutations among malaria non-responsive patients: A case study of Kisii County, Kenya.
Authors: BWOGO PACIFICA chepchumba , Mong’are Samuel , Masai Rael , Matoke-muhia Damaris 
Published: February 2024

Abstract
Malaria poses a substantial global health challenge, with the majority of instances concentrated in countries within Sub-Saharan Africa. A variety of antimalarial medications have been created to address the widespread occurrence of Plasmodium falciparum malaria. Since 2004, Artemisinin-based Combination Therapy (ACT) has been the primary treatment for uncomplicated malaria in Kenya. Nevertheless, there is a rising concern attributable to the increasing reports of ACT resistance, particularly in Southeast Asia, and its extension into Africa. In particular, mutations in the Kelch propeller domain on chromosome 13 (Pfk13) have been associated with resistance to ACT. However, our comprehension of mutation prevalence in Africa remains mostly unexplored, especially as slow parasite clearance becomes increasingly prevalent. In this study, we assess polymorphisms in the Plasmodium falciparum Kelch13 propeller gene among malaria non-responsive patients who attended selected hospitals in endemic regions of Kisii County, Kenya. The research found out that all participants experiencing delayed parasite clearance had low parasitemia levels (< 500) after completing the full dose of the ACT drug, as opposed to their parasitemia levels before taking the ACT drugs. The parasite density for all participants in the study who experienced delayed parasite clearance on the first day before taking the ACT drug showed a high mean ± SE of 13951.9 ± 3564.72. In contrast, during the third-day visit, the mean was notably lower at 327.90 ± 41.11, coinciding with their claim of not responding to the drug. Upon sequencing the K13-propeller gene of the isolates and conducting a search for synonymous and non-synonymous mutations in the propeller region of K13, no polymorphism was observed. Surprisingly, upon further investigation into the amino acids of the isolated samples, silent mutations were observed. Continued global surveillance of artemisinin resistance remains crucial, and our findings offer insights into the possible dissemination of resistant parasites in East Africa. These findings suggest that the detection of silent mutations particularly those associated with delayed parasite clearance following ACT, may imply a gradual emergence of ACT-resistant parasites. This warrants additional investigation through in-vitro assays to determine the functional significance of these findings.
The impact of steatotic liver disease on coronary artery disease through changes in the plasma lipidome
Authors: Björnson Elias , Samaras Dimitrios , Levin Malin , Bäckhed Fredrik , Bergström Göran , Gummesson Anders 
Published: February 2024

Abstract

Steatotic liver disease has been shown to associate with cardiovascular disease independently of other risk factors. Lipoproteins have been shown to mediate some of this relationship but there remains unexplained variance. Here we investigate the plasma lipidomic changes associated with liver steatosis and the mediating effect of these lipids on coronary artery disease (CAD). In a population of 2579 Swedish participants of ages 50 to 65 years, lipids were measured by mass spectrometry, liver fat was measured using computed tomography (CT), and CAD status was defined as the presence of coronary artery calcification (CAC score > 0). Lipids associated with liver steatosis and CAD were identified and their mediating effects between the two conditions were investigated. Out of 458 lipids, 284 were found to associate with liver steatosis and 19 of them were found to also associate with CAD. Two fatty acids, docosatrienoate (22:3n6) and 2-hydroxyarachidate, presented the highest mediating effect between steatotic liver disease and CAD. Other mediators were also identified among sphingolipids and glycerophospholipids, although their mediating effects were attenuated when adjusting for circulating lipoproteins. Further research should investigate the role of docosatrienoate (22:3n6) and 2-hydroxyarachidate as mediators between steatotic liver disease and CAD alongside known risk factors.