bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of ASL Exposure on Spoken Phonemic Discrimination in Adult CI Users: A Functional Near-Infrared Spectroscopy Study
Authors: Nematova Shakhlo , Zinszer Benjamin , Morlet Thierry , Morini Giovanna , Petitto Laura-Ann , Jasińska Kaja K. 
Published: March 2024

Abstract
We examined the impact of exposure to a signed language (American Sign Language, or ASL) at different ages on the neural systems that support spoken language phonemic discrimination in deaf individuals with cochlear implants (CIs). Deaf CI users (N = 18, age = 18–24 yrs) who were exposed to a signed language at different ages and hearing individuals (N = 18, age = 18–21 yrs) completed a phonemic discrimination task in a spoken native (English) and non-native (Hindi) language while undergoing functional near-infrared spectroscopy neuroimaging. Behaviorally, deaf CI users who received a CI early versus later in life showed better English phonemic discrimination, albeit phonemic discrimination was poor relative to hearing individuals. Importantly, the age of exposure to ASL was not related to phonemic discrimination. Neurally, early-life language exposure, irrespective of modality, was associated with greater neural activation of left-hemisphere language areas critically involved in phonological processing during the phonemic discrimination task in deaf CI users. In particular, early exposure to ASL was associated with increased activation in the left hemisphere’s classic language regions for native versus non-native language phonemic contrasts for deaf CI users who received a CI later in life. For deaf CI users who received a CI early in life, the age of exposure to ASL was not related to neural activation during phonemic discrimination. Together, the findings suggest that early signed language exposure does not negatively impact spoken language processing in deaf CI users, but may instead potentially offset the negative effects of language deprivation that deaf children without any signed language exposure experience prior to implantation. This empirical evidence aligns with and lends support to recent perspectives regarding the impact of ASL exposure in the context of CI usage.
Practicing and Patronizing Science in the Republic of Letters: Andreas Dudith’s Radiating Curiosity, Vanity, and Skepticism
Authors: Sebők Marcell 
Published: March 2024

Abstract
Visible for months, the Great Comet of 1577 attracted worldwide attention, particularly among the scholars of Europe’s Respublica Litteraria, and reflections on it were not limited to the books of scientists like Brahe and Kepler; the Hungarian humanist bishop, politician, and nonprofessional astronomer Andreas Dudith (1533–1589) also published a Short Commentary, a fascinating example of the epistemological changes in scientific discourse and astronomical method that characterized the era. With his zealous advocacy of rational argumentation, insistence on the primacy of ‘the most direct causes’, and caustic criticism of superstition, Dudith was in a complex discussion with the Aristotelian tradition and the theological-astrological explanations of his day, thus helping clear the way for modern scientific thought. As his voluminous correspondence makes clear, he spent the final decades of his life trying to make a professional astronomer of himself, and though his friends in the Respublica helped guide his research, he never mastered the requisite mathematical methods, though remained a patron of science.
Low-Level Liquid-Bearing Clouds Contribute to Seasonal Lower Atmosphere Stability and Surface Energy Forcing over a High-Mountain Watershed Environment
Authors: Sedlar Joseph , Meyers Tilden , Cox Christopher J. , Adler Bianca 
Published: March 2024

Abstract
Measurements of atmospheric structure and surface energy budgets distributed along a high-altitude mountain watershed environment near Crested Butte, Colorado, from two separate, but coordinated, field campaigns, Surface Atmosphere Integrated field Laboratory (SAIL) and Study of Precipitation, the Lower Atmosphere, and Surface for Hydrometeorology (SPLASH), are analyzed. This study identifies similarities and differences in how clouds influence the radiative budget over one snow-free summer season (2022) and two snow-covered seasons (2021/22; 2022/23) for this alpine location. A relationship between lower-tropospheric stability stratification and longwave radiative flux from the presence or absence of clouds is identified. When low clouds persisted, often with signatures of supercooled liquid in winter, the lower troposphere experienced weaker stability, while radiatively clear skies that are less likely to be influenced by liquid droplets were associated with appreciably stronger lower-tropospheric stratification. Corresponding surface turbulent heat fluxes partitioned differently based upon the cloud–stability stratification regime derived from early morning radiosounding profiles. Combined with the differences in the radiative budget largely resulting from dramatic seasonal differences in surface albedo, the lower atmosphere stratification, surface energy budget, and near-surface thermodynamics are shown to be modified by the effective longwave radiative forcing of clouds. The diurnal evolution of thermodynamics and surface energy components varied depending on the early morning stratification state. Thus, the importance of quiescent versus synoptically active large-scale meteorology is hypothesized as a critical forcing for cloud properties and associated surface energy budget variations. The physical relationships between clouds, radiation, and stratification can provide a useful suite of metrics for process understanding and to evaluate numerical models in such an undersampled, highly complex terrain environment.
Estimating Directional Wave Spectra Properties in Nonbreaking Waves from a UAS-Mounted Multibeam Lidar
Authors: Feddersen Falk , Marques Olavo B. , MacMahan James H. , Grenzeback Robert L. 
Published: March 2024

Abstract
Wave spectra and directional moment measurements are of scientific and engineering interest and are routinely estimated with wave buoys. Recently, both fixed-location and uncrewed aircraft system (UAS)-mounted lidar have estimated surfzone wave spectra. However, nearshore wave statistics seaward of the surfzone have not been measured with lidar due to low return number, and nearshore directional moments have not been measured at all. We use a multibeam scanning lidar mounted on a gasoline-powered UAS to estimate wave spectra, wave slope spectra, and directional moments on the inner shelf in ≈10-m water depth from an 11-min hover and compare to a collocated wave buoy. Lidar returns within circular sampling regions with varying radius R are fit to a plane and a 2D parabola, providing sea surface and slope time series. Wave spectra across the sea–swell (0.04–0.4 Hz) band are robustly estimated for R ≥ 0.8 m. Estimating slope spectra is more challenging. Large R works well in the swell band, and smaller R works well at higher frequencies, in good agreement with a wave buoy inferred slope spectrum. Directional Fourier coefficients, estimated from wave and slope spectra and cross-spectra, are compared to a wave buoy in the sea–swell band. Larger R and the 2D parabola-fit yield better comparison to the wave buoy. Mean wave angles and directional spreads, functions of the directional Fourier coefficients, are well reproduced at R = 2.4 m and the 2D parabola-fit, within the uncertainties of the wave buoy. The internal consistency of the UAS-lidar-derived results and their good comparison to the Spotter wave buoy demonstrate the effectiveness of this tool for estimating wave statistics.

Significance Statement
Previously fixed-location or hovering lidar has been used to estimate wave spectra in the surf and swash zone where lidar returns are high due to the reflectance of foam. We present a methodology to accurately estimate wave spectra and directional properties on the inner shelf where waves are not breaking using a hovering uncrewed aircraft system with a mounted lidar. The estimated wave spectra and directional statistics are compared well with a Spotter wave buoy, demonstrating the method’s robustness.
The anterior saphenous vein. Part 3. Systematic review of the literature and payor coverage policies. Endorsed by the American Vein and Lymphatic Society, the American Venous Forum and the International Union of Phlebology
Authors: Drgastin Rachel , Boyle Edward M , Labropoulos Nicos , Caggiati Alberto , Gasparis Antonios , Doganci Suat , Meissner Mark 
Published: March 2024

Objective The objective of this study is to systemically review the literature on Anterior Saphenous Vein (ASV) reflux treatment and insurance impediments to treatment coverage. Methods A literature search was performed using a PRISMA framework. In addition, a cross-sectional analysis of insurance policies for ASV treatment was evaluated. Results Published evidence and treatment considerations in the literature for ASV treatment are discussed. In 155 of 226 (68.6%) insurance policies reviewed coverage of ASV ablation was allowed while 62/226 (27.4%) did not specify coverage and 9/226 (4.0%) specified ASV treatment was not covered. Of the 155 that provide ASV coverage, 98 (62.2%) provide coverage with criteria such as requiring prior treatment of the great saphenous vein. Conclusions Vein treatment experts should continue to advocate to insurance carriers to update their varicose vein treatment policies to reflect the substantial clinical evidence so that patients with ASV reflux can be appropriately treated.
Identifying metrics and designing measurable outcomes in the electronic health record to evaluate pharmacist intervention in an oral chemotherapy program
Authors: Koppinger Shelby , Weil Elizabeth , Ruffcorn Nichole , McGurty Erin , Creal Kevin , Rhoades Melissa 
Published: March 2024

Introduction Due to the increased utilization of oral anticancer agents, pharmacist-led oral anticancer programs have emerged to meet the needs of oral anticancer management. Currently, at Froedtert & MCW, there is a lack of established tools to collect metrics which demonstrate the value of a pharmacist-led oral anticancer program. Methods The purpose of this project is to establish metrics that reflect the interventions pharmacists are performing, and second, to develop a documentation tool which can reliably extract discrete data on the identified metrics. Results Eight of the 10 desired metrics were included in the documentation tool. Two questionnaires were created to allow for easy data retrieval of the metrics. The “initial” questionnaire focuses on interventions made at the time of starting an oral anticancer agent, while the “follow-up” questionnaire focuses on interventions made during the subsequent monitoring. The introduction of the questionnaire tool was well received by end users and did not add to the pharmacist’s overall workload. Conclusions By establishing metrics that reflect pharmacist interventions in a pharmacist-led oral anticancer program and creating a documentation tool to collect discrete data related to those metrics from the electronic health record, we at Froedtert & MCW are better able describe the workload of the ambulatory oncology pharmacists with regard to their interventions and monitoring of oral anticancer agents. This data will be used to establish differences in pharmacist workload between clinics, justify pharmacist resources, and provide a snapshot of the patient population served as part of the oral anticancer program.
Predictors of coronary artery calcium burden in asymptomatic patients with newly diagnosed type 2 diabetes mellitus
Authors: Hyseni Violeta , Elezi Shpend , Gjikolli Bujar , Bakalli Aurora 
Published: March 2024

Objective Long-standing diabetes mellitus is often associated with cardiovascular complications. We aimed to evaluate the presence, extent and composition of subclinical atherosclerotic plaques in coronary arteries by Computed Tomography in patients with newly diagnosed type 2 diabetes mellitus (NDT2DM), and to identify the predictors. Methods In this study 101 consecutive patients with NDT2DM were included. Patients were categorized into five groups based on their Coronary Artery Calcium Score (CACS) ranging from 0, 0-10, 11-100, 101-400 to >400. All parameters were compared across these groups. Results The average patient age was 54.4 ± 11.6 years and 48 (47.5%) were females. Eight (7.9%) patients had CACS 0, 6.9% CACS 1-10, 42.6% CACS 11-100, 22.8% CACS 101-400 and 19.8% had CACS >400. Multiple regression analysis for the general data identified weight ( p = .04) and systolic blood pressure ( p = .033) as independent predictors for CACS. Conclusions Asymptomatic patients with NDT2DM in more than 90% of cases may present with calcified atherosclerotic plaques and this may be predicted by: patient weight and the level of systolic arterial pressure. Our study emphasizes the need for comprehensive care and early prevention of cardiovascular complications in individuals with NDT2DM.
Breasts as a perceived barrier to physical activity in Mexican women: A cross-sectional study
Authors: Valles-Verdugo Gabriela , Renteria Ivan , Gómez-Figueroa Julio , Villarreal-Ángeles Mario , Ochoa-Martínez Paulina , Hall-López Javier , Gallegos-Ramírez Juan , Chacón-Araya Yamileth , Moncada-Jiménez José 
Published: March 2024

Background: Scarce evidence exists on barriers to physical activity in Mexican women. Despite evidence from other countries, no research has investigated the influence of the breast on PA in this population. Objective: To determine the association between the breast and physical activity in Mexican women. Design: Cross-sectional observational study. Methods: Volunteers were 279 Mexican women from Veracruz, Durango, and Baja California states, who completed a paper survey of their demographics, brassiere characteristics, breast pain, and frequency and amounts of weekly physical activity. Results: The first barrier to physical activity was time constraints, followed by breast-related issues. Breast pain was reported by 47.1% of women, and the breast as a barrier to physical activity participation was reported by 30.6%. Responses, such as “I am embarrassed by excessive breast movement” and “My breasts are too big” were the most frequently reported breast-related barriers to physical activity. Breast pain was associated with the menstrual cycle and exercise. Breast health knowledge and pain intensity were unrelated to moderate- and vigorous-intensity physical activity. The 36.4% and 6.7% of women did not meet weekly moderate- and vigorous-intensity physical activity guidelines, respectively. Weekly moderate- and vigorous-intensity physical activity was similar between women reporting breast pain and those who did not. Conclusions: Because the breast was the second most significant barrier to physical activity, it is imperative to increase breast health knowledge in Mexican women to reduce impediments to physical activity.
Voices From the Industry: How EdTech Leaders Responded to the COVID-19 Pandemic
Authors: Kim Deoksoon , Borowiec Katrina , Yatsu Drina Kei , Wortham Stanton 
Published: March 2024

PurposeEducational technology (“EdTech”) served a pivotal role in keeping schools functioning during the beginning of the COVID-19 pandemic. Little is known about EdTech leaders’ roles in shaping this response. This study explores EdTech leaders’ perspectives and backgrounds, their response to the pandemic, how they envision their roles as educators, and their perspectives about how technology facilitates educational innovation.Design/Approach/MethodsThis study uses a qualitative, phenomenological approach to understand how 11 EdTech leaders experienced the pandemic. Participants were recruited for interviews in summer 2021 via purposive sampling to include diverse backgrounds and perspectives. Data were analyzed inductively.FindingsThe findings show that a four-category typology can be used to describe EdTech leaders’ diverse backgrounds and experiences. Leaders emphasized equity and open collaboration in their pandemic responses, by expanding access to their tools and adapting their products as users’ needs evolved. EdTech leaders anticipate streamlined user experiences, improvements in online learning, and increased adoption of artificial intelligence and simulated learning environments.Originality/ValueThis study addresses a gap in the research concerning EdTech leaders’ perspectives on their efforts to support educators and their experiences during the pandemic. We hope this study sparks additional research on EdTech leaders’ experiences and roles in education.
Satisfaction With Care Among Cancer Survivors With Medicare Coverage: Are There Rural Versus Urban Inequities?
Authors: Borders Tyrone F. 
Published: March 2024

Introduction: Rural cancer survivors often face greater barriers to treatment, which may translate into worse satisfaction with health care. Objective: To examine rural versus urban differences in satisfaction with health care among Medicare cancer survivors. Methods: Data are from the 2020 Medicare Current Beneficiary Survey (MCBS). Rao-Scott chi-square analyses were conducted to examine rural versus urban inequities in satisfaction with 9 dimensions of health care (health professionals’ concern for health, information about what was wrong, ease/convenience from home, ease of obtaining answers over telephone, getting needs taken care of at same location, availability of specialists, overall quality, and out-of-pocket costs, and availability of care at night/on weekends). Multiple logistic regression analyses were conducted to test for rural/urban differences while adjusting for race/ethnicity, gender, marital status, educational attainment, health insurance (traditional Medicare, Medicare Advantage, dual Medicaid coverage, employer, or self-purchased insurance), and self-rated overall health. Results: Rural cancer survivors were less satisfied with the ease/convenience of getting to health professionals (93.35% rural and 96.87% urban) and less satisfied with getting all health care needs taken care of at the same location (88.32% rural and 92.22% urban). These rural/urban differences persisted when adjusting for other factors. Conclusions: Health care providers serving rural areas may need to consider new strategies to satisfy some of the unique needs of rural cancer survivors, such as better organizing services at single clinic sites and utilizing telehealth when feasible to reduce the need to travel for in-person services.
Changes in Functional Meniscal Morphology During Skeletal Growth and Maturation
Authors: Kaushal Shankar G. , Barnett Samuel C. , Hosseinzadeh Shayan , Perrone Gabriel S. , Kiapour Ata M. 
Published: March 2024

Background: Little is known on how meniscal morphology develops during skeletal growth and maturation and its subsequent relationship with the corresponding bony anatomy. Hypotheses: (1) Meniscal dimensions and morphology would change by age during skeletal growth and maturation in different ways in boys compared with girls. (2) Morphological features of the medial and lateral menisci would correlate to medial and lateral femoral condyle curvatures. Study Design: Cross-sectional study; Level of evidence, 3. Methods: Anatomic features of the medial and lateral menisci were measured on magnetic resonance imaging scans from 269 unique knees (age, 3-18 years; 51% female) with no prior history of injury, congenital or growth-related skeletal disorders, or bony deformities. Morphological shape-based measurements were normalized to tibial plateau width or determined as ratios of meniscal dimensions. The association between age and anatomy was analyzed with linear regression. Two-way analysis of variance with the Holm-Šídák post hoc method was used to compare anatomy between sexes in different age groups. Linear regression was used to evaluate the relationship between femoral condyle curvature radius and meniscal morphology in each compartment after adjusting for age and sex. Results: Meniscal length, width, horn distance, mean cross-sectional area (CSA), and mean height increased with age in both sexes ( R2 > 0.1; P < .001). Age-related changes in meniscal morphology were seen in normalized length, width, horn distance, and mean height; width-to-length ratio; horn distance-to-length ratio (lateral meniscus only); normalized mean CSA (except lateral meniscus in girls); and mean tip angle ( R2 > 0.04; P < .02). Sex-based differences were also found, with some morphological differences (normalized length and height) throughout development ( P < .03) and size differences (length, width, and mean CSA) in later development ( P < .01). After adjusting for age and sex, there were significant correlations between medial condyle curvature radius and normalized width, width-to-length ratio, horn distance, horn distance-to-length ratio, mean CSA, and mean height of the medial meniscus ( P≤ .041) and between lateral condyle curvature radius and normalized length, mean height, and mean tip angle of the lateral meniscus ( P≤ .004). Conclusion: Age-related changes in meniscal dimensions and morphology, most notably a nonuniform growth pattern in meniscal geometry, occurred during skeletal growth and maturation, with different trends in boys than in girls.
Excess of circulating apotransferrin enhances dietary iron absorption in mice
Authors: Tsyplenkova Sofiya , Charlebois Edouard , Fillebeen Carine , Pantopoulos Kostas 
Published: March 2024

Abstract
Intravenous injection of excess apotransferrin enhances dietary iron absorption in mice and triggers accumulation of plasma non–transferrin-bound iron. Injected fluorescent-labeled transferrin colocalizes with lamina propria macrophages, consistent with the recently proposed iron absorption checkpoint involving macrophage-mediated transferrin degradation.
Kinome expression profiling improves risk stratification and therapeutic targeting in myelodysplastic syndromes
Authors: Yao Chi-Yuan , Lin Chien-Chin , Wang Yu-Hung , Kao Chein-Jun , Tsai Cheng-Hong , Hou Hsin-An , Tien Hwei-Fang , Hsu Chia-Lang , Chou Wen-Chien 
Published: March 2024

Abstract
The human kinome, which comprises &gt;500 kinases, plays a critical role in regulating numerous essential cellular functions. Although the dysregulation of kinases has been observed in various human cancers, the characterization and clinical implications of kinase expressions in myelodysplastic syndromes (MDS) have not been systematically investigated. In this study, we evaluated the kinome expression profiles of 341 adult patients with primary MDS and identified 7 kinases (PTK7, KIT, MAST4, NTRK1, PAK6, CAMK1D, and PRKCZ) whose expression levels were highly predictive of compromised patient survival. We then constructed the kinase stratification score (KISS) by combining the weighted expressions of the 7 kinases and validated its prognostic significance in 2 external MDS cohorts. A higher KISS was associated with older age, higher peripheral blood and marrow blast percentages, higher Revised International Prognostic Scoring System (IPSS-R) risks, complex karyotype, and mutations in several adverse-risk genes in MDS, such as ASXL1, EZH2, NPM1, RUNX1, STAG2, and TP53. Multivariate analysis confirmed that a higher KISS was an independent unfavorable risk factor in MDS. Mechanistically, the KISS-high patients were enriched for gene sets associated with hematopoietic and leukemic stem cell signatures. By investigating the Genomics of Drug Sensitivity in Cancer database, we identified axitinib and taselisib as candidate compounds that could potentially target the KISS-high myeloblasts. Altogether, our findings suggest that KISS holds the potential to improve the current prognostic scheme of MDS and inform novel therapeutic opportunities.