bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Foveal Avascular Region and Macular Blood Vessel Density in Prediabetic Patients with OCT-A Findings
Authors: UTLU BAHADIR , UTLU Elif Sedanur , ÇİNİCİ Emine , Akgöz Hasan , BAYRAKÇEKEN Kemal , KOZAN Betül DERTSİZ 
Published: March 2024

Abstract
Purpose: This study aimed to compare the macular layer thickness, macular vessel density and Foveal avascular zone (FAZ) perimetric and areal OCT-A measurements of prediabetic patients with normoglycemic healthy subjects.
Material - Methods: Thirty patients (Group A) with fasting plasma glucose (between 100-125 mg/dl), postprandial plasma glucose (between 140-199 mg/dl) and HbA1C (between 5.7-6.4%) values within the defined limits were included in the study. In addition, 30 healthy normoglycemic patients (Group B) were included as a control group. All participants underwent OCT-A to measure macular superficial capillary plexus (inner) and deep capillary plexus vessel density (outer) and foveal avascular zone width. Participants with poor image quality, refractive error, glaucoma, intraocular surgery, chorioretinal atrophy-like fundus findings and comorbid comorbidities were excluded from the study.
Results: The perfusion density of the SCP and DCP decreased in the patient group compared to the control group and this difference was statistically significant in the inferior and temporal quadrants in the deep plexus and the temporal quadrant in the superficial plexus (p<0.05). Although there were changes around the foveal avascular zone and FAZ area between the groups, the difference was not statistically significant (p >0.05). Macular thickness was thicker in all quadrants in Group A, while the difference between nasal and inferior was statistically significant (p<0.05).
Conclusion: Prediabetic patients showed increased macular thickness, decreased macular perfusion density and increased width of the FAZ in some patients. Although the results show that the disease affects ocular structures, more large-scale studies are needed to better understand the associated complications.
The impact of the national centralized drug procurement on the use of original and generic targeted anti- tumor drugs in Hohhot, China: an interrupted time-series analysis
Authors: Wu Rihan , Gong Zhaotang , Wang Weisong , Zhu Benben , SiRi GuLeng 
Published: March 2024

Abstract
Objectives: In December 2022, the implementation of the seventh round of national centralized drug procurement(NCDP) in China, encompassing a range of targeted anti-tumor drugs. This study aims to assess the explored the different effect of the NCDP on three original and generic targeted anti-tumor drugs use in clinical practice.
Method: Clinical drug volume data was collected covering 18 months before, during, and after the the seventh round of the National Centralized Drug Procurement in Inner Mongolia. Three targeted anti-tumor drugs associated with the seventh round of NCDP were chosen for investigation and categorized into original and generic products based on bidding outcomes. Interrupted time-series method was employed to estimate the net effect of policy impact.
Results: After the implementation of national centralized drug procurement (NCDP), there has been a significant increase in the utilization of generic targeted antineoplastic drugs. The volume of generic afatinib(30mg) increased by 25.78DDDs, the expenditures decreased by 3641.14 yuan (95 % CI: -5581.16 to -1701.12, p=0.001), and the DDDc decreased by 124.35 yuan (95 % CI: -128.23 to -120.46, p<0.001). The volume of generic afatinib(40mg) increased by 65.19DDDs (95 % CI: 35.38 to 96.43, p<0.001), the expenditures increased by 1304.93 yuan (95 % CI: 700.55 to 1909.31, p<0.001), and the DDDc decreased by 120.2 yuan (95 % CI: -120.2 to -120.2, p<0.001). The volume of generic sunitinib increased by 75.79DDDs (95 % CI: 37.99 to 112.46, p<0.001), the expenditures decreased by 15869.78 yuan (95 % CI: -23275.57 to -8463.98, p<0.001) , and the DDDc decreased by 243.28 yuan. There was no significant change trend in volume, expenditures and DDDc of the three original targeted drugs after NCDP intervention.
Conclusions: After the policy intervention, generic afatinib (40mg) successfully aligned with the objectives of NCDP by reducing drug costs and enhancing patient affordability; however, the desired outcomes were not achieved for generic afatinib (30mg) and generic sunitinib. This discrepancy may be attributed to the inherent clinical efficacy and safety profiles of these drugs. Therefore, in implementing NCDP, it is necessary to enhance the clinical efficacy and safety of generic targeted anti-tumor drugs while considering economic efficiency.
Protocol of the Reformation study: a prospective, multicenter, randomized controlled trial on the improvement of rheolytic thrombectomy for acute deep vein thrombosis of the whole lower limb by primary popliteal vein thrombosis clearance
Authors: Ni Qihong , Ye Xiande , He Chunshui , Zhao Hui , Lou Wensheng , Zhuang Hui , Sang Hongfei , Wu Ziheng , Ye Meng 
Published: March 2024

Abstract
Introduction: Pharmacomechanical thrombectomy (PMT) can be a useful treatment for restoring vein patency quickly especially for extensive acute deep vein thrombosis (DVT). However, previous evidence failed to validate the effectiveness of PMT in reducing the incidence of post-thrombotic syndrome (PTS). To address this controversy, the Reformation study aims to improve rheolytic thrombectomy for acute deep vein thrombosis of the lower limb through primary popliteal vein thrombosis clearance.
Method and analysis: Reformation is a prospective randomized multicenter trial. It has 160 patients in two groups: the modified access group (80 patients) and the traditional access group (80 patients). The purpose of this study is to assess whether the modified access approach for removing inflow thrombus in a one-stage procedure is more effective in enhancing the success rate of the procedure and reducing the incidence of post-thrombotic syndrome during a 24-month follow-up period, for patients with acute whole limb DVT.
Ethics and dissemination: The Reformation study has been registered at www.clinicaltrials.gov (registration number: NCT05286710). The study protocol has been approved by the Institutional review board and Human Research Ethics Committee of Renji Hospital, School of Medicine, Shanghai Jiao Tong University (Approved number: KY2021-067-A). The results will be disseminated by publication in a peer-reviewed journal.
Trial registration number: NCT05286710
Protocol version and date: V.1.2, 20 August 2022
Transcriptome profiling on Euphorbia kansui elicited with methyl jasmonate
Authors: Li Peng , Liang Xiaoqing , Zhang Min , Fang Xiaoai , Cai Xia 
Published: March 2024

Abstract
Euphorbia kansui Liou of Euphorbia (Euphorbiaceae) is an endemic traditional
medicine in China, and exerted effective antitumor activity due to its specific metabolic
composition, especially terpenoid.This study was designed to illustrate the detailed effects of MeJA on E. kansui through transcriptome before and after MeJA treatment. 96,040 unigenes with an average length of 812 bp were identified, among which 53,822 unigenes were annotated according to function database. Of note, we noted that MeJA treatment significantly altered the transcription pattern of E. kansui, especially at 24 hat of MeJA treatment. MeJA treatment mainly altered the expression of genes that functioned in biosynthesis of cutin, wax, flavonoid and terpenoid represented by MVA pathway in E. kansui. Typically, MeJA treatment mainly activated the expression of genes for terpenoid biosynthesis in EK at 36 hat. Further qRT-PCR verified that exogenous application of 20 μM MeJA greatly upregulate the expression levels of genes encoding enzymes in the terpenoid biosynthesis in E. kansui at 36 hat. Importantly, the contents of total terpenoid in E. kansui at 36 hat of MeJA treatment were promoted to 2.80 times of those without MeJA treatment. our results highlighted that MeJA could promoted the accumulation of terpenoid in E. kansui, which provided basis for cultivating high quality of E. kansui with higher levels of
bioactive compounds.
Unmasking of molecular players: Proteomic profiling of vitreous humor in pathologic myopia
Authors: Wen Yue , Ren Chi , Zhu Li , Huang Lvzhen , Qi Huijun , Yu Wenzhen , Wang Kai , Zhao Mingwei , Xu Qiong 
Published: March 2024

Abstract

Background: The purpose of this study was to examine the differentially expressed proteins in the vitreous humor (VH) of eyes with and without pathologic myopia (PM).
Methods: This was a cross-sectional, observational study. Patients with idiopathic epiretinal membrane (ERM), macular holes (MH), or myopic retinoschisis (MRS) who underwent vitrectomy provided VH samples. The differentially expressed proteins were identified using a label-free quantitative proteomic analysis, and the expression of three of the differentially expressed proteins was validated using ELISA.
Results: The expression of tubulin alpha 1A (TUBA1A) and eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) was substantially greater in the PM group (MH-PM, MRS-PM) than in the control group (MH, ERM), although xylosyltransferase 1 (XYLT1) was significantly less expressed. While XYLT1 concentrations were lower in PM patients than in controls, EEF1A1 and TUBA1A concentrations in the vitreous were greater in PM patients.
Conclusions: Our research offers novel insights into the molecular alterations in PM patients' VH, EEF1A1, TUBA1A, and XYLT1 might be important for chorioretinal cell apoptosis, scleral extracellular matrix (ECM) synthesis, and scleral remodeling as well as potential new targets for PM treatment.
Associations between high-sensitivity C-reactive protein and hypertension base on NHANES 2017-2018
Authors: Wang Shihong , Lv Deliang , Wu Xiaobing , Xie Fengzhu , Shang Qinggang , Xie Wei , Zhao Zhiguang 
Published: March 2024

Abstract
Background: High-sensitivity C-reactive protein (hsCRP) is a systemic inflammation marker. Currently, the relationship between hsCRP and hypertension is still controversial. The purpose of this study is to further investigate the possible link between hsCRP and hypertension.
Methods: The cross-sectional data was obtained from the National Health and Nutrition Examination Survey (NHANES) 2017-2018. We used multiple logistic regression models to examine the possible relationship between hsCRP and hypertension. Restricted cubic spline (RCS) models were used to further detect thenonlinear dose-response relationship between hsCRP and hypertension.
Results: A total of 4307 participants were enrolled in this study, including 2085 (48.4%) males and 2222 (51.6%) females. 1453 (33.7%) participants were over 60 years old and 1584 (36.8%) participants had hypertension. After adjusting for all potential confounders, the positive association between hsCRP and hypertension was statistically significant (OR=1.017; 95%CI: 1.006~1.028). Besides, compared to the lowest quartile of hsCRP, the highest quartile was associated with a higher risk of hypertension (OR=1.572; 95%CI: 1.237~1.997). Furthermore, the restricted cubic spline (RCS) model also showed a nonlinear relationship between hsCRP and hypertension (P for nonlinear < 0.001).
Conclusions: The cross-sectional population based study demonstrates the significant positive association between hsCRP and hypertension. Early screening for hsCRP and initiation of treatment may be helpful in preventing hypertension.
Rapid and convenient detection of Weissella ceti with loop-mediated isothermal amplification
Authors: Fang Huahua , Pan Jiankun , Wang Yingfei , Tao Ye , Zheng Chaoli , Wang Minghao , Qian Dandan , Sun Yanling 
Published: March 2024

Abstract
Weissella ceti, one of Gram-positive lactic‐acid bacteria, as a newly emerging pathogen can cause the rainbow trout (Oncorhynchus mykiss) with Weissellosis. Until now, it is not easy to identify W. ceti from other pathogens by symptoms of the fish infected especially at the primary stage of infection, and thus a method of identification was needed to determine conveniently and quickly this pathogen. In this study, loop-mediated isothermal amplification (LAMP) detection has higher specificity and sensitivity for W. ceti. The primers according to the hemolysin A gene were designed, and the LAMP detection was accomplished within 30 min at 63 ℃. The mimimum concentration of LAMP detection for W. ceti was 5.9*10− 6 ng/µl, which was 100 times more sensitive than traditional PCR. The LAMP detection confirmed the high specificity for detecting W. ceti, whereas the other six pathogens used were all negative reactions. In addition, it was validated that the LAMP detection was also effective in simulated clinical samples. Based on the results, the LAMP detection was rapid and convenient for point-of-care testing diagnosis of W. ceti.
Utilization of breakthrough curve for Estimation of Dispersion Coefficients of Subsurface Aquifer using Machine Learning
Authors: Ayaz Md , Ali Md. Shaheer 
Published: March 2024

Abstract
To forecast the future direction of pollutant movement, the advection dispersion equation is employed with positive time increments. Solving the Advection-dispersion equation necessitates prior knowledge of the dispersion coefficient, posing the challenge of estimating these coefficients within a subsurface aquifer. The task of deducing longitudinal and transverse coefficients for the subsurface aquifer emerges as an inverse problem. In this study, an innovative approach using Artificial Neural Network (ANN) modeling technique is introduced to estimate the dispersion coefficient of the subsurface aquifer. Training data is based on pollutant concentration over time, commonly referred to as a breakthrough curve. By focusing solely on the section of the breakthrough curve near the peak concentration, the required sampling duration are minimized. This is in contrast to previous research where the complete breakthrough curve was employed to estimate dispersion coefficients. Notably, both longitudinal and transverse dispersion coefficients are concurrently estimated in this study. The developed ANN model is trained using the Levenberg-Marquardt algorithm and is assessed under two and three-dimensional scenarios, incorporating both error-free and error-prone concentration data with a margin of up to 10%. The outcome of the performance evaluation underscores the robustness and efficacy of the ANN model in predicting longitudinal and transverse dispersion coefficients for subsurface aquifers.
Genetic landscape of nodular goiter, thyroid nodules with intermediate features between nodular goiter and follicular adenoma
Authors: Duan Ting , Ren Dingyuan , Jin Yanling , Lu Xiaming , Guo Zhenying 
Published: March 2024

Abstract
Background
Nodular goiters (NG) and follicular adenoma (FA) are common thyroid benign nodules and thyroid nodules with intermediate features between nodular goiter and follicular (ING) is used to describe the disease with borderline features. The genetic landscape of these three diseases is poorly investigated comparatively.
Methods
Clinical information of NG, ING and FA was retrieved and reviewed. Cytology and histology of the pathologic archives were reviewed to confirm the diagnosis. DNA and RNA were extracted to be submitted to qPCR assay to detect BRAF, TERT, RET, RAS, PAX8 and NTRK genetic aberration.
Results
The demographic, clinical, image and cytologic features in NG and ING are similar. Most disease presents a benign clinical and cytologic behavior, causing no diagnostic difficulty. Low frequency (< 10%) RAS gene was found in NG and ING. Patients with FA are older than whom with NG or ING. FA lesion size is smaller than ones in NG or ING. Although sonography demonstrated most FA nodules as benign category, the cytologic evaluation demonstrated a considerable percentage (45%) of atypia disease. Additionally, much higher frequency of RAS gene abnormality has been found in FA. And PAX8-PPARG gene is found in 17.9% FA and in no NG/ING cases.
Conclusion
NG/ING and FA is in the same spectrum and represents two ends of the spectrum of thyroid benign nodular condition. Differentiation of ING from NG has little clinical significance and would not be recommended. FA is devoid from NG/ING clinically and genetically. Interpretation of genetic abnormality should be cautious.
Safety and efficacy of covered self-expandable metallic stent for choledochojejunal anastomotic stricture: A multi-center retrospective cohort study
Authors: Iwasa Yuhei , Iwashita Takuji , Iwata Keisuke , Okuno Mitsuru , Shimojo Kota , Uemura Shinya , Tezuka Ryuichi , Senju Akihiko , Iwata Shota , Shimizu Masahito 
Published: March 2024

Abstract
Background
Benign choledochojejunal anastomotic stricture (CJS) is a complication of pancreaticoduodenectomy and choledochojejunostomy. Typically managed with endoscopic balloon dilatation, CJS has a high recurrence rate. Covered metallic stent (CMS) placement is a potential alternative; however, a comprehensive evaluation is lacking.
Objectives
The aim of this study was to evaluate the treatment outcomes of CMS placement in patients with CJS.
Methods
We retrospectively analyzed 46 patients who underwent balloon dilation via endoscopic retrograde cholangiopancreatography using a double-balloon endoscope for CJS between October 2010 and October 2023. The study outcomes included technical and clinical success rates, adverse event rates, choledochojejunal anastomotic stricture recurrence rates, and time to recurrence for balloon dilation and CMS treatment for CJS.
Results
The technical and clinical success rates were 100% for both treatments. Recurrence of CJS was observed in 35% (14/40) of the patients in the balloon dilation group. The recurrence rate was significantly higher in the balloon dilatation group than in the CMS group (35% vs. 0%, p = 0.006). The time to CJS recurrence was significantly shorter in the balloon dilatation group than in the covered metallic stent group (NR vs. NR, p = 0.03).
Conclusion
Placement of CMS for treating patients with CJS was demonstrated to be an effective and safe method with a lower recurrence rate than balloon dilation.
Long-Term Survival Outcomes Following Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Metastasis of Hepatocellular Carcinoma patients
Authors: Yan Guojun , Zhang Kai , Yan Lijun , Zhang Yanbin 
Published: March 2024

Abstract
Background: Patients with hepatocellular carcinoma with peritoneal metastasis (HCC-PM) have a poor prognosis. Traditional treatments have limited effects on survival. The safety and efficacy of cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS+HIPEC) have been shown in other peritoneal cancers. This study evaluated the role of CRS+HIPEC in HCC-PM.
Methods: A retrospective analysis of HCC-PM patients treated with CRS+HIPEC at Beijing Shijitan Hospital from March 2017 to December 2023 was conducted to assess clinical features, severe adverse events (SAEs), and overall survival (OS) rates.
Results: The study population comprised 10 HCC-PM patients who underwent CRS+HIPEC. The median peritoneal cancer index (PCI) was 25, and complete cytoreduction (CC0 ~ 1) was achieved in half of the patients. Three patients experienced SAEs within 30 days postoperatively. The 1-year, 3-year, and 5-year OS rates were 89.0%, 89.0%, and 21.0%, respectively, with a median OS1 of 107.8 months and OS2 of 49.9 months. The median progression-free survival (PFS) was 5.0 months.
Conclusion: CRS+HIPEC offers significant benefits to patients with HCC-PM. A selected group of patients may achieve prolonged PFS. Incorporating CRS+HIPEC into the treatment paradigm can thus be considered a strategic therapeutic option for patients with HCC-PM.
Research on Lane Line Detection Method Based on Cross Attention Mechanism
Authors: Huang Bingqiang , Wang Shiqian , Fei Zhenshun , Xiang Xinjian , Tian Shaohua , Tang Fuying , Yuan Tianshun 
Published: March 2024

Abstract
Lane detection is a key technical challenge in autonomous driving and advanced driving assistance systems. The current lane detection system has insufficient robustness and low detection accuracy problem in complex and harsh environmental conditions, and lacks research on visual cues without information. In order to accurately and effectively detect multiple lanes in challenging scenarios and meet the real-time requirements of actual driving, a lane detection method based on cross attention mechanism is proposed in this paper. Firstly, by embedding a cross attention mechanism in the feature extraction module, the contextual information of surrounding pixels on the intersection path is obtained, and useful information is collected from other regions for accurate lane detection; Secondly, anchor point detection is selected based on the prior position of the designed lane starting position; Finally, combining mixed anchor points to represent lane coordinates, using row and column anchors to learn lane coordinates and improve the real-time performance of lane detection models. The detection model RCCLaneNet designed in this paper was evaluated on the TuSimple and CULane datasets. The experimental results showed that the F1 of this method can reach 97.05% on the TuSimple dataset, 78.5% on the CULane dataset, and the real-time inference speed index FPS can reach +150. The proposed model achieves advanced performance in lane detection tasks in complex scenes while maintaining real-time detection efficiency, and has good universality in actual driving scenarios.