bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cost-Effectiveness of Radar Localisation Versus Wire Localisation for Wide Local Excision of Non-palpable Breast Cancer
Authors: Nguyen Chu Luan , Cui Rebecca , Zhou Michael , Ali Fatema , Easwaralingam Neshanth , Chan Belinda , Graham Susannah , Azimi Farhad , Mak Cindy , Warrier Sanjay 
Published: March 2024

Abstract
Background
Wire localisation (WL) is the “gold standard” localisation technique for wide local excision (WLE) of non-palpable breast lesions but has disadvantages that have led to the development of wireless techniques. This study compared the cost-effectiveness of radar localisation (RL) to WL.

Methods
This was a single-institution study of 110 prospective patients with early-stage breast cancer undergoing WLE using RL with the SCOUT® Surgical Guidance System (2021–2023) compared with a cohort of 110 patients using WL. Margin status, re-excision rates, and surgery delays associated with preoperative localisation were compared. Costs from a third-party payer perspective in Australian dollars (AUD$) calculated by using microcosting, break-even point, and cost-utility analyses.

Results
A total of 110 WLEs using RL cost a total of AUD$402,281, in addition to the device cost of AUD$77,150. The average additional cost of a surgery delay was AUD$2318. Use of RL reduced the surgery delay rate by 10% (p = 0.029), preventing 11 delays with cost savings of AUD$25,496. No differences were identified in positive margin rates (RL: 11.8% vs. WL: 17.3%, p = 0.25) or re-excision rates (RL: 14.5% vs. WL: 21.8%, p = 0.221). In total, 290 RL cases are needed to break even. The cost of WLE using RL was greater than WL by AUD$567. There was a greater clinical benefit of 1.15 quality-adjusted life-years (QALYs) and an incremental cost-utility ratio of AUD$493 per QALY favouring RL.

Conclusions
Routine use of RL was a more cost-effective intervention than WL. Close to 300 RL cases are likely needed to be performed to recover costs of the medical device.
Clinical trial registration: ACTRN12624000068561.
Soft Governance Across Digital Platforms Using Transparency
Authors: Doshi Anil R. , Schmidt William 
Published: March 2024

Platform governance helps align the activities of participating actors to deliver value within the platforms. These platforms can operate in environments where governance is intentionally or conventionally weak in favor of open access, frictionless transactions, or free speech. Such low- or no-governance environments leave room for illegitimate actors to penetrate platforms with illegitimate content or transactions. We propose that an external observer can employ transparency mechanisms to establish “soft” governance that allows participants in a low-governance environment to distinguish between sources of legitimate and illegitimate content. We examine how this might work in the context of disinformation Internet domains by training a machine learning classifier to discern between low-legitimacy from high-legitimacy content providers based on website registration data. The results suggest that an independent observer can employ such a classifier to provide an early, although imperfect, signal of whether a website is intended to host illegitimate content. We show that the independent observer can be effective at serving multiple platforms by providing intermediate prediction results that platforms can align with their unique governance priorities. We expand our analysis with a signaling game model to ascertain whether such a soft governance structure can be resilient to adversarial responses.Funding: Funding for this research was provided by UCL School of Management and Emory University.Supplemental Material: The online appendix is available at https://doi.org/10.1287/stsc.2023.0006 .
EDUCAÇÃO MATEMÁTICA E PESSOAS COM DEFICIÊNCIAS VISUAIS: CONVÍVIO, DIÁLOGO E FORMAÇÃO PROFISSIONAL PARA A CONSTRUÇÃO DE EXPERIÊNCIAS MATEMÁTICAS EM AMBIENTES PEDAGÓGICOS
Authors: De Assis Jean Felipe 
Published: March 2024

Para contextualizar práticas inclusivas em Educação Matemática para pessoas com deficiências visuais, um breve panorama de propostas legislativas é apresentado para salientar a responsabilidade de todos os cidadãos na superação dos desafios e na promoção de práticas que resultem em experiências didáticas adequadas. Observa-se que a responsabilidade coletiva perpassa condições físicas, curriculares e avaliativas que não se resumem a práticas individualizadas em ambientes educacionais específicos, mas são resultantes de cenários educacionais excludentes que não propiciam condições adequadas de acesso, permanência e socialização. A importância de grupos de pesquisa, ensino e extensão nos ambientes escolares é salientada, sobretudo para diagnóstico, orientação, formação profissional, produção de materiais didáticos e criação de ambientes pedagógicos. Embora existam avanços legais, estruturais e tecnológicos, convívio e diálogo são ressaltados como elementos primordiais para que os conteúdos matemáticos, as expectativas curriculares e as práticas didáticas possam ser adequadamente contextualizadas para pessoas com deficiências visuais.
EV TİPİ MİKRODALGA FIRINLARDA SERAMİK PİŞİRİM ARAŞTIRMALARI VE MİKRODALGA PİŞİRİM HAZNESİ YAPIM ÖNERİLERİ
Authors: ÖRKEN Aziz Baha , CANDURAN Kaan 
Published: March 2024

Seramik pişirim çeşitliliğine olan yönelim son yıllarda artarak seramik dünyasının ilgi odağı olmuştur. Birçoğumuzun evlerinde yer alan mikrodalga fırınlar da bu ilgiyi fazlasıyla görmektedir. Mikrodalga fırınlarda uygun pişirim haznelerinin kullanımı ile seramik pişirimine olanak sağlanmaktadır. Gerek endüstriyel gerekse sanat seramiğinde mikrodalga fırınlarda pişirim haznesi yapımı, sır pişirimi, alternatif pişirim olanakları ile ilgili araştırmalar çeşitlenmektedir. Uzun yıllardır evlerimizde yemek ısıtmak ve pişirmek için kullanılan mikrodalga fırınlar son yirmi yıl içinde sır ve bünye denemeleri için hızlı ve düşük maliyetli bir seramik deneme fırını haline dönüşmeye başlamıştır. Geleneksel pişirme ve ısıtma yöntemlerinden farklı olarak mikrodalga fırınlarda pişirme ve ısıtma işlemlerinin sürelerinin ve enerji tüketiminin daha az olduğu bilinmektedir.
Bu araştırmada öncelikle tarihsel süreç içerisinde gelişen mikrodalga enerjisi ve mikrodalga fırınları ve mikrodalga fırınların seramik alanında nasıl kullanıldıkları araştırılmıştır. Mikrodalga fırınlarda seramik pişirimi için kullanılan hazneler incelenmiş, haznelerin üretildiği malzeme alternatifleri ve daha kişisel hazne biçimlendirme yöntemleri araştırılarak denemeleri yapılmıştır. Mikrodalga fırınlar için araştırılan bu haznelerle, geleneksel pişirim teknikleri farklı killer ve sırlar 2450 Mhz ev tipi bir mikrodalga fırın kullanılarak yapılmıştır. Deneme süreçlerinde elde edilen bilgiler görsellerle desteklenerek yöntemler açıklanmıştır. Araştırma sonucunda farklı kil bünyelerinin bisküvi pişirimi, normal sırlı pişirimler ve alternatif bir pişirim tekniği olan Raku pişirimi uygulamaları yapılmıştır.
Application of a Digital Twin Model in the Packaging Process of the Panel Furniture Industry
Authors: Wang Guokun , Xiong Xianqing , Ma Ying , Xu Xiutong 
Published: March 2024

Abstract
The packaging process in panel furniture manufacturing enterprises is the final process in production. However, there exists a lack of effective interaction and integration between the manufacturing processes and the information system. This challenge becomes more significant in the context of intelligent manufacturing. To address this, we propose a generalized digital twin workshop model for the packaging process in panel furniture manufacturing enterprises. Using this model, we establish a digital twin workshop for Company W’s packaging process, which improves interaction and integration with the information system. By analyzing the data from the workshop service system and the workshop twin data, we identify inefficiencies in the automatic packaging line and propose an optimization scheme using the digital twin workshop model. Through simulation in the virtual workshop and actual verification, we demonstrate that the proposed scheme improves the production efficiency of the automatic packaging line by approximately 20 percent and reduces the need for 5 to 6 packaging workers. Our study presents a new solution for upgrading the information system in the packaging process of panel furniture, contributing to the development and optimization of the furniture industry in the era of intelligent manufacturing.
Food Insecurity, Low Household Income, and Low Education Level Increase the Risk of Having Metabolic Dysfunction–Associated Fatty Liver Disease Among Adolescents in the United States
Authors: Paik James M. , Duong Sandy , Zelber-Sagi Shira , Lazarus Jeffrey V. , Henry Linda , Younossi Zobair M. 
Published: March 2024

INTRODUCTION:
In the United States, 10.2% households (HH) report child food insecurity. We assessed associations between metabolic dysfunction–associated fatty liver disease (MASLD) and food insecurity among the adolescents in the United States.

METHODS:
This cross-sectional study was performed using data from the National Health and Nutrition Examination Survey 2017–2018. Food insecurity was assessed by the US Department of Agriculture Child Food Security Survey Module. MASLD was defined by transient elastography.

RESULTS:
Among 771 adolescents (aged 12–18 years) (mean age 14.7 years; 52.5% male; 50.9% White, 12.7% Black, 24.4% Hispanic, and 12.1% other), 9.8% reported food insecurity; MASLD prevalence of 10.12% (95% confidence interval [CI] 7.13%–13.20%) affecting 4.27 million adolescents; and nonalcoholic fatty liver disease prevalence of 10.77% (95% CI 7.76–13.78) affecting 4.52 million adolescents. There was near-perfect concordance between MASLD and nonalcoholic fatty liver disease (Cohen's κ coefficient of 0.971, 95% CI 0.946–0.996). The prevalence of MASLD was greater among food-insecure adolescents vs food-secure ones (17.4% vs 9.4%) and adolescents living with a low HH income vs those with a higher HH income (15.0% vs 7.2%) and living with a head of HH with a lower education level vs one with a higher education level (18.0% vs 8.2%) (P < 0.05). The fully adjusted model showed that compared with adolescents living in a higher HH income, food-insecure adolescents living in low income HH had a 3-fold greater risk (odds ratio [OR] 3.25, 1.31–8.08) of having MASLD, while food-secure adolescents living in low-income HH had no increased risk (OR 1.58, 0.85–2.93, P = 0.139). The fully adjusted odds of having MASLD was elevated by +163% with the presence of HTN (OR 2.63, 1.02–6.78), +241% with being Hispanic (OR 3.41, 1.36–8.56), and +138% with being male (OR 2.38, 1.20–4.75). In addition, a 1-unit increase in BMI was associated with 25% increase in the odds of having MASLD (OR 1.25, 1.17–1.33) among US adolescents.

DISCUSSION:
Food insecurity is associated with MASLD among US low-income adolescents especially Hispanic male individuals with obesity and hypertension. Policies addressing inequities are needed.
A novel approach for protein secondary structure prediction using encoder–decoder with attention mechanism model
Authors: Sonsare Pravinkumar M. , Gunavathi Chellamuthu 
Published: March 2024

Abstract
Computational biology faces many challenges like protein secondary structure prediction (PSS), prediction of solvent accessibility, etc. In this work, we addressed PSS prediction. PSS is based on sequence-structure mapping and interaction among amino acid residues. We proposed an encoder–decoder with an attention mechanism model, which considers the mapping of sequence structure and interaction among residues. The attention mechanism is used to select prominent features from amino acid residues. The proposed model is trained on CB513 and CullPDB open datasets using the Nvidia DGX system. We have tested our proposed method for Q
3 and Q
8 accuracy, segment of overlap, and Mathew correlation coefficient. We achieved 70.63 and 78.93% Q
3 and Q
8 accuracy, respectively, on the CullPDB dataset whereas 79.8 and 77.13% Q
3 and Q
8 accuracy on the CB513 dataset. We observed improvement in SOV up to 80.29 and 91.3% on CullPDB and CB513 datasets. We achieved the results using our proposed model in very few epochs, which is better than the state-of-the-art methods.
COVID-19 vaccine reviews on YouTube: What do they say?
Authors: Kang Da-Young , Ki Eyun-Jung 
Published: March 2024

Abstract
After the Covid-19 vaccination started, social media users created an enormous amount of content on the vaccines. Especially in the early stages of vaccination, people searched and watched YouTube videos sharing personal experiences after getting the vaccines (i.e., vaccine review videos), usually titled “I got the COVID-19 vaccine.” Few studies have examined the characteristics and impacts of vaccine review videos on viewers’ responses (e.g., likes, dislikes, comments). This study investigates the content of, and reactions to, the most-viewed Covid-19 vaccine review videos on YouTube, based on the social communication framework. A quantitative content analysis of 148 vaccine review videos revealed their unique characteristics, including source expertise, message valence, narration, and topics. Most of the videos had a positive tone, with some urging vaccination and showing pro-vaccine attitudes. Furthermore, source expertise and hybrid message types (messages conveyed in narrative and informative ways) were not significantly related to positive responses. Rather, non-expert videos received more positive responses. The findings concern the public opinions surrounding new vaccines, including related concerns and attitudes. Given the positive tone of the content, vaccine review content made by diverse groups can be encouraged by public health institutions regardless of the creators’ expertise.
Organoids as preclinical models of human disease: progress and applications
Authors: Chen Baodan , Du Cijie , Wang Mengfei , Guo Jingyi , Liu Xingguo 
Published: March 2024

Abstract
In the field of biomedical research, organoids represent a remarkable advancement that has the potential to revolutionize our approach to studying human diseases even before clinical trials. Organoids are essentially miniature 3D models of specific organs or tissues, enabling scientists to investigate the causes of diseases, test new drugs, and explore personalized medicine within a controlled laboratory setting. Over the past decade, organoid technology has made substantial progress, allowing researchers to create highly detailed environments that closely mimic the human body. These organoids can be generated from various sources, including pluripotent stem cells, specialized tissue cells, and tumor tissue cells. This versatility enables scientists to replicate a wide range of diseases affecting different organ systems, effectively creating disease replicas in a laboratory dish. This exciting capability has provided us with unprecedented insights into the progression of diseases and how we can develop improved treatments. In this paper, we will provide an overview of the progress made in utilizing organoids as preclinical models, aiding our understanding and providing a more effective approach to addressing various human diseases.
Efficient second-harmonic generation of quasi-bound states in the continuum in lithium niobate thin film enhanced by Bloch surface waves
Authors: Lin Yun , Ye Yong , Fang Ziliang , Chen Bingyu , Zhang Haoran , Yang Tiefeng , Wei Yuming , Jin Yunxia , Kong Fanyu , Peng Gangding , Cao Hongchao , Guan Heyuan , Lu Huihui 
Published: March 2024

Abstract
Nonlinear optics has generated a wide range of applications in the fields of optical communications, biomedicine, and materials science, with nonlinear conversion efficiency serving as a vital metric for its progress. However, the weak nonlinear response of materials, high optical loss, and inhomogeneous distribution of the light field hamper the improvement of the conversion efficiency. We present a composite grating waveguide structure integrated into a Bragg reflector platform. This design achieves high Q in the spectral range by exploiting the unique properties exhibited by the bound states in the Bloch surface wave-enhanced continuum, and efficient second-harmonic generation by close-field amplification with the optical field tightly localized in a nonlinear material. By manipulating the symmetry of the grating, a precise tune over the near field within a designated wavelength range can be achieved. Specifically, we select a photonic crystal configuration supporting surface waves, employing TE polarization conditions and an asymmetry factor of −0.1 between the composite gratings. This configuration resonates at a fundamental wavelength of 783.5 nm, exhibiting an impressive Q-factor of 106. Notably, at an incident light intensity of 1.33 GW/cm2, we achieve a normalized electric field strength of up to 940 at the fundamental frequency and a second-harmonic conversion efficiency of up to 6 × 10−3, significantly amplifying the second-harmonic response. The proposed configuration in this investigation has the potential to be integrated into the field of nonlinear optics for sensing frequency conversion applications.
Tropes and play: a new account on embodied figures of thought
Authors: Söffner Jan 
Published: March 2024

AbstractThis paper aims at expanding theories of metaphorical reasoning to other tropes. Asking why figurative language tends to fall into a limited number of patterns, it first examines approaches that offer an answer – ranging from antique rhetoric theory, Hans Blumenberg, Harald Weinrich, Donald Davidson, and Roman Jakobson to George Lakoff and Mark Johnson. By then turning to Giambattista Vico, it puts forth the argument that a limited set of pre-structured ways of embodied reasoning is hard-wired in and enacted by different aspects of children’s ways of playing – and provides the foundation for structures ofthinking inthe adult life.
Chitosan in cancer therapy: a dual role as a therapeutic agent and drug delivery system
Authors: Atmaca Harika , Oguz Ferdi , Ilhan Suleyman 
Published: March 2024

Abstract
Although chemotherapy is still the most preferred treatment for cancer, most chemotherapeutic agents target both cancer cells and healthy cells and cause serious side effects due to high toxicity. Improved drug delivery systems (DDSs), which enhance the efficacy of current chemotherapeutic drugs while reducing their toxicity, offer potential solutions to these challenges. Chitosan (CS) and its derivatives are biopolymers with biodegradable, biocompatible, and low-toxicity properties, and their structure allows for convenient chemical and mechanical modifications. In its role as a therapeutic agent, CS can impede the proliferation of tumor cells through the inhibition of angiogenesis and metastasis, as well as by triggering apoptosis. CS and its derivatives are also frequently preferred as DDSs due to their properties such as high drug-carrying capacity, polycationic structure, long-term circulation, and direct targeting of cancer cells. Various therapeutic agents linked to CS and its derivatives demonstrate potent anticancer effects with advantages such as reduced side effects compared to the original drugs, owing to factors like targeted distribution within cancer tissues and sustained release. This review emphasizes the utilization of CS and its derivatives, both as therapeutic agents and as carriers for established chemotherapeutic drugs.
Vom Verein zum Unternehmen?
Authors: Ahrens Ralf 
Published: March 2024

Abstract
Using the example of the German Mechanical and Plant Engineering Association (Verband Deutscher Maschinen- und Anlagenbau, VDMA), this paper examines the viability of corporate history approaches in the history of the associations. The VDMA, one of the largest trade associations in the Federal Republic of Germany, faced increasing criticism from its member companies in the late 60s. The complex organisation, which had to reconcile the interests of some three dozen branches of industry and various regional groups, was considered inefficient and lacking in profile. The reaction was to launch a reform programme with rationalisation measures, a modern image policy and an expansion of the range of services on offer that showed certain traits of entrepreneurial behaviour. At the same time, the dues system was reformed, but the introduction of a splitting of the dues to the association’s headquarters and the branches was dispensed in order not to endanger the cohesion of interests. Both areas of reform thus demonstrate the imits of entrepreneurial logic in the organisation of an association.
Marija Gimbutas and the Ethnic Origin of the Baltic Nation
Authors: Merkevičius Algimantas 
Published: March 2024

Birutė Marija Alseikaitė-Gimbutienė (English Marija Gimbutas), is one of the most prominent and well-known archaeologists of the 20th century, pioneer of archaeomythology, creator of new theories in archaeology. In her scientific research, she paid a great attention to the ethnic origins and development of nations.This article analyzes the Theory of Baltic Ethnic Origins formulated by Gimbutas. The solution to this important scientific problem involves two main research stages. The first stage is formulation of the Theory of Indo-European homeland, named the Kurgans Theory. The second stage is formulation of the Theory of the origins of Balts. According to Gimbutas, a few cultural systems participated in the formation of the Balts: the indoeuropeans and substrat culture, that is Indo-Europeanized people of Central Europe. The Indo-Europeans migrated from their homeland, located in the steppe zone north of the Black and Caspian seas, in three waves between 4400/4200 and 3000/2800 BC, ultimately reaching Europe and Indo-Europeanizing it.A secondary Indo-European Homeland was formed in Central Europe, from which the Indo-European culture spread to the Baltic region and other European regions.The last, third wave of newcomers, from around 3000–2800 BC, had the greatest influence on the southeastern and eastern Baltic region and the surrounding territories. During several centuries of assimilation between local inhabitants and newcomers, around 2500–2000 BC, in the territory between the Vistula River in the west and the Volga and Oka rivers in the east, several cultural groups of Proto-Balts were formed. During further ethnocultural processes, around 2000 BC. the Baltic ethnos was formed. In the 2nd and 1st millennium BC. and in the first part of the 1st millennium AD the Balts inhabited a huge area in the North Eastern part of Europe.
Modelling of closed-cell aluminum foam using Weaire–Phelan unit cells
Authors: Zhylgeldiyev A. , Chernyshov D. , Haider S. , Mankovits T. 
Published: March 2024

AbstractDesign and testing of real materials is a costly process and usually requires some specific equipment. To alleviate this task numerical methods can be leveraged. In this work we show possible modelling technique for closed-cell material structure using Weaire–Phelan unit cells. As an example existing aluminum structures were used and modelled parametrically, allowing to establish different geometrical models for different applications. Numerical simulations for compression was also done on the developed models to reveal the material response. The influence on the cell wall thickness and the friction between the material and the compression plate was investigated. It was found that the friction coefficient has no significant effect on the material response, except in the case where bonded connection was assumed. It was also demonstrated that material response and the porosity controlled by cell wall thickness have an approximately linear relationship with each other. This method proved to be a flexible and alternative solution of real laboratory tests and targeted to reduce costs of material design.