bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modulation of the Sinus Rate during Ventricular Fibrillation
Authors: WASMUND STEPHEN L. , PAI RAKESH K. , FREEDMAN ROGER A. , ABEDIN MOEEN , DACCARETT MARCOS , SEGERSON NATHAN M. , ZAITSEV ALEXEY V. , HAMDAN MOHAMED H. 
Published: October 2008

Background:
During supraventricular and ventricular tachycardia, the arterial baroreflex predominates with minimal contribution from the cardiopulmonary reflex. To our knowledge, the role of the arterial baroreflex gain (BRG) during and immediately following termination of ventricular fibrillation (VF) has not been characterized.
Objective:
We hypothesized that (1) arterial BRG correlated with sinus node cycle length (SNCL) changes during VF, and that (2) the greater the arterial BRG, the greater the blood pressure (BP) recovery following successful defibrillation.
Methods:
Arterial BRG was assessed in 18 patients referred for the implantation of a defibrillator incorporating an atrial lead. The average SNCL was measured during the 5 seconds prior to VF induction and the last 5 seconds during VF before defibrillation. Percent SNCL change (%ΔSNCL) was determined. Arterial BP recovery was calculated as the difference in mean BP following defibrillation compared to during VF.
Results:
Arterial BRG ranged between –3 and 18 ms/mmHg. During VF, SNCL shortened in 11 patients (group A, mean %ΔSNCL =–15%), and surprisingly lengthened in seven patients (group B, mean %ΔSNCL = 5%). There was no correlation between %ΔSNCL and arterial BRG. In fact, arterial BRG in group A was lower when compared with group B (P = 0.075). Similarly, there was no correlation between arterial BRG and BP recovery.
Conclusions:
We found no correlation between arterial BRG and %ΔSNCL during VF, or BP recovery following defibrillation. Our findings of SNCL lengthening in 7 of 18 patients suggest that in some patients, arterial BRG plays a minor role during VF with a greater contribution from the cardiopulmonary BRG.
One‐Year Outcomes with the TAXUS Liberté Stent in the Real World: The TAXUS OLYMPIA Registry (Phase I)
Authors: AHMED WAQAR HABIB , ZAMBAHARI ROBAAYAH , AL‐RASHDAN IBRAHIM , AL NAEEMI ABDULLAH , SAEED FUAD A. , MASCIOLI STEPHEN 
Published: October 2008

Background: The TAXUS OLYMPIA registry is a prospective, postapproval registry collecting clinical outcomes data on patients receiving the TAXUS Liberté paclitaxel‐eluting stent during routine interventional cardiology practice.
Methods: Between February and July 2005, 529 patients receiving the TAXUS Liberté stent at 16 centers in the Middle East, South/Central America, and Asia/Pacific regions were enrolled in Phase I of OLYMPIA. The primary end‐point was TAXUS Liberté stent‐related cardiac events (cardiac death, MI, and revascularization) at 30 days postimplant. Additional clinical assessment was conducted at 6 and 12 months. OLYMPIA phases II and III are in clinical follow‐up and will be reported separately.
Results: One‐year clinical follow‐up is available for 98% of patients. Complex patients and lesions were prevalent, including: 50% diabetes mellitus, 49% multivessel disease, 30% multiple stenting, 48% AHA/ACC type B2/C lesions, 19% long lesions (>26 mm), and 40% small vessels (≤2.75 mm). At 1 year, the cardiac event rate was 4.1%, including 1.5% cardiac death, 1.5% MI, and 2.3% target vessel revascularization (TVR). The TAXUS Liberté stent‐related cardiac event rate was 3.7% at 1 year. Stent thrombosis (ST) occurred in 1.7% of patients, with three cases occurring >30 days postprocedure. One‐year cardiac event rates among complex subpopulations (diabetics 5.0%, multiple stents 3.8%, long lesions 3.1%, and small vessels 2.9%) were comparable to the overall study population.
Conclusions: In conclusion, this first report of real‐world experience with the TAXUS Liberté stent demonstrates the safety and clinical utility of this stent in the broader spectrum of coronary disease treated in everyday practice.
Automating the Surface Force Tank and Void Assessment Process
Authors: PRIOLETTI MARK J. , MICHAEL TOBIN E. 
Published: October 2008

AbstractWireless technology is the networking backbone in homes and offices worldwide. This same technology now offers a maintenance solution for Surface Force Atlantic tank and void material condition assessments. Wireless technology puts the power of a desktop computer into the hands of tank and void assessors as they enter these cavernous shipboard compartments. With a few taps on a personal digital assistant (PDA) touch‐screen, assessors can record equipment configuration errors, annotate any one of over 100 possible tank condition abnormalities, or generate a repair work order with pre‐written problem description and recommended solution statements. At the end of a typical workday, these PDAs are wirelessly connected to a mid‐Atlantic regional maintenance center (MARMC) commercial off the shelf (COTS) server, where data export files are formatted for ship and shore 3M input. As Navy commands look to reduce operational and maintenance budgets, this automated and wireless business solution offers a means of maintaining the original tank and void maintenance goal of inspecting and trending degradation at a fraction of the previous required time and effort. Additionally, this process allows for the processing of assessment results to the SNAPSHOT database, the master tank, and void historical data repository. This automated process was successfully tested and implemented on 27 Norfolk‐based ships in 2006. With significant cost and time savings realized, the next logical step was to develop a distant support capability for remote locations. The goal here was to incorporate these same standards and processes into southeast regional maintenance center (SERMC) ships while maintaining the MARMC‐located COTS server as the main hub for work scheduling and PDA loading. To accomplish these goals, a process was developed using standard web technology for transferring PDA work assignment files (tanks and voids scheduled for assessment) from the main COTS server located at MARMC to the remote SERMC tank assessor equipped with a PDA. Once the assigned tank and void condition assessments are accomplished, files are then returned to MARMC using the same web technology. MARMC handles these remote files the same way as they do local files for data export to ship and shore 3M systems. This distant support capability was successfully tested and implemented on three Mayport‐based ships in December 2006. This paper will detail the significant steps taken to automate a maintenance process that used a hand‐scribed paper process and standard US Navy maintenance reporting infrastructures. The lessons learned during the upgrade process, maintenance advantages that maximize efficiency, cost effectiveness, and surface force ship reliability will be also be discussed.
Novel cryoprecipitate for wound healing and skin grafts in rats
Authors: Scholz Thomas , Waltzman Joshua , Wirth Garrett A , Dyson Senait W , Owens William J , Shanbrom Edward , Evans Gregory RD 
Published: October 2008

AbstractThe authors sought to evaluate the ability of locally administered enhanced cryoprecipitate (eCryo) to improve the wound healing of split thickness skin grafts (STSG) and their donor sites. An STSG (5 × 5 cm) was harvested on the back of 30 rats and divided into four areas that were then treated in one of the following groups: A: ‘standard’ dressing without STSG; B: eCryo without STSG; C: eCryo with STSG coverage and D: STSG alone. Macroscopic and histological assessments (histomorphometric grading scale and cellular composition) were evaluated at days 7, 14, 21 and 28 for wound healing. All wound beds as well as STSGs healed well without any complications. Eighty per cent of the STSG showed a histological graft take of >75% after 28 days. There were no statistically significant differences of macroscopic or histological results between the groups at any time point. Preparation of eCryo is easy and effective. Its use as an adhesive for STSGs is safe and shows similar results as controls. The theoretical benefits of eCryo did not show significant differences. Possible reasons as well as important findings for future research on wound healing are discussed.
Effects of Fibrinogen and α2‐Macroglobulin and Their Apheretic Elimination on General Blood Rheology and Rheological Characteristics of Red Blood Cell Aggregates
Authors: Kirschkamp Thomas , Schmid‐Schönbein Holger , Weinberger Andreas , Smeets Ralf 
Published: October 2008

AbstractMethods of therapeutic apheresis, such as plasma exchange or rheopheresis eliminate moderately aggregating macromolecules like fibrinogen, as well as strongly aggregating substances like α2‐macroglobulin from blood. In order to examine the specific effect of eliminating α2‐macroglobulin as a highly aggregating macromolecule, this study aimed to analyze the different rheological properties of: (i) moderately aggregating red blood cells (RBCs; inducible by fibrinogen); and (ii) strongly aggregating RBCs (inducible by α2‐macroglobulin). In vitro, RBC aggregate geometry was determined in the presence of strong and moderate aggregation inducing macromolecules. In vivo, flow behavior of RBC aggregates was analyzed by intravital microscopy. Using network scanning, the number of perfused and non‐perfused microvessels was determined. In vitro, the higher adhesive forces of strongly aggregating RBCs led to both a higher packing density of single RBCs within aggregates, expressed as a significantly reduced thickness of individual RBCs, and greater deformation, expressed as a significantly diminished offset between RBCs and an increased curvature of RBCs at the ends of the aggregates. In vivo rheoscopy showed that only high aggregating RBCs persisted in the precapillary bed and led to the absence of RBCs in up to 40% of nutritive capillaries. These novel findings are of importance regarding recent developments in clinical hemorheology, specifically the clinical use of hemapheretic therapies for diseases in which impaired microcirculation plays a role in either their development or progression, such as age‐related macular degeneration and complications of diabetes mellitus. Our data support that procedures reducing the concentration of α2‐macroglobulin in blood by extracorporeal elimination might provide a more efficient improvement of overall blood fluidity in microcirculatory beds.
Relationship Between the Weight of Parathyroid Glands and Their Secretion of Parathyroid Hormone in Hemodialysis Patients With Secondary Hyperparathyroidism
Authors: Kakuta Takatoshi , Tanaka Reika , Kanai Genta , Miyamoto Yoshiyasu , Inagaki Miho , Suzuki Hajime , Fukagawa Masafumi , Saito Akira 
Published: October 2008

AbstractSecondary hyperparathyroidism is one of the common and important abnormalities of mineral metabolism in hemodialysis patients. In this study we investigated the relationship between the weight of individual parathyroid glands (PTG) and their secretion of parathyroid hormone (PTH). Sixty‐four PTGs in 16 patients undergoing parathyroidectomy (PTx) at our hospital were included in this study. Patients' ages ranged from 34 to 68 years (60.3 ± 6.6 years). They were undergoing maintenance dialysis therapy for 81–256 months (175.3 ± 56.0 months). The cause of end‐stage renal failure was chronic glomerulonephritis in all patients. We measured whole PTH (wPTH) levels before PTx and 15 min after the resection of each individual gland (Δ whole PTH). A positive correlation was found between the weight of individual gland and ultrasonography (US) size of individual PTG (r = 0.91, P < 0.001, N = 53). A positive correlation was found between the total mass of the gland and the total volume of PTG on US (r = 0.896, P < 0.001, N = 16). A positive correlation was found between the mass of each individual gland and Δ whole PTH (r = 0.625, P < 0.001, N = 64); however, massive PTGs did not secrete more whole PTH per unit mass (0.01 g). Determination of the volume of PTGs by US is a good indicator of their weight. Larger PTGs secrete more whole PTH per gland, whereas these PTGs did not have the ability to secrete more PTH per unit volume.
A Case Report of Plasma Exchange, Steroids, Mycophenolate Mofetil and Cyclophosphamide in Acquired Factor VIII Inhibitors
Authors: Rech Jürgen , Hueber Axel J , Leipe Jan , Manger Bernhard , Schett Georg , Kallert Stefan 
Published: October 2008

AbstractInduction of factor VIII (FVIII) inhibitors sometimes occurs in patients with hemophilia due to frequent supplementation of FVIII. The inhibitor is rarely detected in non‐hemophilic patients; however, an association has been described in patients with chronic inflammatory diseases, such as autoimmune diseases (e.g. SLE and rheumatoid arthritis), malignant tumors and drug allergies, and also to pregnant or aged individuals without underlying disease. We report on an 82‐year‐old patient who was transferred to our hospital after the diagnosis of acquired FVIII inhibitor. On admission the laboratory results showed no detectable FVIII activity (0%, normal range 70–100%), prolongation of coagulation time (APTT 102.4 s), and severe anemia 7.8 g/dL (normal range 12–16 g/dL). On physical examination multiple subcutaneous hematomas were detected and further bleeding in his left pectoralis muscle was observed. Despite extensive investigation no underlying disease was detected. Thirty‐six courses of plasma exchange with 360 units of fresh frozen plasma replacement daily were conducted. High dose steroids and mycophenolate mofetil (MMF) were given throughout the course, and cyclophosphamide was administered once. Thirty‐four units of erythrocytes were applied during this time. After 36 courses of plasma exchange in combination with high dose steroids, FVIII activity and coagulation time normalized and bleeding could be stopped. The patient was discharged in good health 48 days after admission. Hence, we present a case of severe idiopathic FVIII inhibitor‐positive hemophilia successfully treated with the combination of plasma exchange, corticosteroids, cyclophosphamide and MMF.
Localization and Extent of Peritoneal Calcification in Three Uremic Patients on Continuous Ambulatory Peritoneal Dialysis
Authors: Dejima Kyoko , Mitsuhashi Hiroshi , Yasuda Gen , Hirawa Nobuhito , Ikeda Yumiko , Umemura Satoshi 
Published: October 2008

AbstractPeritoneal calcification in three patients on continuous ambulatory peritoneal dialysis (CAPD) was reviewed, and the relation between the localization and extent of calcium deposits detected by abdominal computed tomography (CT) and clinical signs was evaluated. Case 1 was a 48‐year‐old man with abdominal pain, hemoperitoneum and secondary hyperparathyroidism after receiving CAPD for seven years. An abdominal CT revealed linear peritoneal calcification in the pelvic cavity and liver surface, and his symptoms resolved after switching to hemodialysis. His clinical course and pathological findings were compatible with those in progressive calcifying peritonitis. Case 2 was a 26‐year‐old man presenting with abdominal pain, vomiting and fullness two years after switching to hemodialysis, because of uncontrolled overhydration following 13 years of CAPD. Plaque‐like calcification outlining the small intestine and parietal peritoneum was noted on CT. Case 3 was a 59‐year‐old man who had abdominal distention, vomiting and diarrhea three months after switching to hemodialysis due to loss of peritoneal function following 10 years of CAPD. CT revealed diffuse sheet‐like calcification surrounding the bowel and mesentery, adherent dilated bowel loops and ascites. These CT findings suggested the existence of encapsulating peritoneal sclerosis (EPS) in cases 2 and 3. Findings from our three patients indicate that peritoneal calcification is not always accompanied by EPS; however, monitoring peritoneal calcification and other findings by abdominal CT, even after cessation of CAPD, is crucial to maintain vigilance on whether the subclinical signs, which are temporally diagnosed as progressive calcifying peritonitis, advance to EPS.
EFFECTS OF PRETREATMENT WITH ROSEMARY (ROSMARINUS OFFICINALIS L.) IN THE PREVENTION OF LIPID OXIDATION IN SALTED TILAPIA FILLETS
Authors: DA SILVA AFONSO M. , SANT'ANA L.S. 
Published: October 2008

ABSTRACT To delay lipid oxidation during meat processing, synthetic antioxidants have been used in the food industry, but the consumers' concern over their toxicity increased interest in research with natural antioxidants. The aim of this work was to analyze the water activity (Aw), thiobarbituric acid reactive substances (TBARS), moisture and trichloroacetic acid‐soluble nitrogen (TCASN) in brined tilapia fillets treated or pretreated with natural rosemary extract (Rosmarinus officinalis) and stored for 240 days at −18C. Higher Aw (0.900 ± 0.010) and moisture (70.13 ± 0.20) values were observed in the pretreated fillets. The TBARS values in the treatment (3.31 ± 0.79) and pretreatment (3.39 ± 0.53) were half the value of the control treatment (6.14 ± 1.21) at 240 days. Statistical differences were observed in TCASN values in 180 (0.112 ± 0.020) and 240 (0.132 ± 0.017) days, with the pretreatment showing a more protective effect in protein oxidation. In this study, rosemary proved to be protective during the frozen storage, especially when its extract was used as pretreatment, before the salting process.PRACTICAL APPLICATIONSFish consumption is highly elastic, because the annual average consumption of seafood per person in Brazil is only 6.8 kg. The federal government has set a goal to increase it to 12 kg by 2007.Salting is an older food preservation process still used today, and is extremely important because, despite advances in food technology, increased monitoring and improved knowledge, it is emphasized as an easy, cheap and effective process that does not require refrigeration. Tilapia is a highly prolific fish, with a production volume that is increasingly higher each year in Brazil. Therefore, it calls for interesting research to allow an increased shelf life for this species.
EFFECT OF PACKAGING MATERIALS ON COLOR, VITAMIN C AND SENSORY QUALITY OF REFRIGERATED MANDARIN JUICE
Authors: BELTRÁN‐GONZÁLEZ FELIPE , PÉREZ‐LÓPEZ ANTONIO J. , LÓPEZ‐NICOLÁS JOSÉ M. , CARBONELL‐BARRACHINA ÁNGEL A. 
Published: October 2008

ABSTRACT Refrigerated mandarin juice was packed in four different containers, three cartons with different composition and one polyethylene terephthalate transparent bottle, and was stored at 4C for 90 days. During the storage of these juices, changes in the headspace gas composition, vitamin C, and CIE L*, a* and b* color coordinates were evaluated. In addition, a consumer panel evaluated the sensory color, fresh mandarin flavor and presence of off‐flavors in the juices. Experimental data indicated that the deterioration of mandarin juices (ascorbic acid degradation and darkening of color) was triggered by the rise in oxygen in the headspace of the storage containers. The type of container played a predominant role in determining the juice quality, with carton containers with an inner layer of aluminum foil providing the juices with the best quality throughout their storage.PRACTICAL APPLICATIONSResults from this study will provide manufacturers of mandarin juice with information dealing with the storage and quality of juices packed in different containers. In this way, if manufacturers want to use transparent polyethylene terephthalate (PET) bottles showing the color and appearance of the juice, they will be aware that the shelf life of the juice will be much shorter than in packed cartons; this reduction will be from more than 90 to 36 days (PET bottle). On the other hand, if manufacturers want to use carton for their packaging, they will be aware that using a container with a thick inner layer of aluminum foil will maintain the quality of the juice for a longer time (over 90 days) compared with a shelf life of about 54 days from cartons with an inner layer of ethylene vinyl alcohol copolymers.
The accuracy of the Lactate Pro hand‐held analyser to determine blood lactate in healthy dogs
Authors: Tas O. , De Rooster H. , Baert E. , Doom M. H. , Duchateau L. 
Published: October 2008

Objectives:The objective of this study was to determine the accuracy of the Lactate Pro hand‐held analyser in measuring blood lactate levels.Methods:Blood was drawn from 15 healthy dogs into five tubes containing Na‐EDTA. Lactate was measured immediately using the Lactate Pro analyser and a laboratory reference method. Further samples were analysed 120, 240, 480 and 1440 minutes later to artificially increase the lactate levels. Lactate was measured in blood samples of 60 healthy dogs using the Lactate Pro analyser to determine the reference interval of lactate concentration in normal dogs.Results:The correlation between the lactate concentration measured with the Lactate Pro analyser and the reference method was high. Lactate levels were lower when measured with the hand‐held analyser than with the traditional laboratory determination. The reference interval for blood lactate concentrations in healthy dogs established by the Lactate Pro analyser was from the detection limit (0·8 mmol/l) up to 3·3 mmol/l.ClinicalSignificance:The Lactate Pro analyser provides quick and reliable measurements of blood lactate in dogs with blood lactate levels up to 10 mmol/l. Because of its small sample size, this analyser will be particularly appropriate for use in small animal intensive care.
Perverse bundles and Calogero–Moser spaces
Authors: Ben-Zvi David , Nevins Thomas 
Published: October 2008

AbstractWe present a simple description of moduli spaces of torsion-free 𝒟-modules (𝒟-bundles) on general smooth complex curves, generalizing the identification of the space of ideals in the Weyl algebra with Calogero–Moser quiver varieties. Namely, we show that the moduli of 𝒟-bundles form twisted cotangent bundles to moduli of torsion sheaves on X, answering a question of Ginzburg. The corresponding (untwisted) cotangent bundles are identified with moduli of perverse vector bundles on T*X, which contain as open subsets the moduli of framed torsion-free sheaves (the Hilbert schemes T*X[n] in the rank-one case). The proof is based on the description of the derived category of 𝒟-modules on X by a noncommutative version of the Beilinson transform on P1.