bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neuromyths about dyscalculia and dyslexia among educators in the UK
Authors: Van Herwegen J. , Outhwaite L. A. , Herbert E. 
Published: April 2024

AbstractDyslexia and dyscalculia are two examples of high‐incidence specific learning difficulties (SpLDs) that have similar prevalence and can often co‐occur. It is currently unclear how familiar educators in the UK are with dyscalculia and how this compares to dyslexia and what, if any, neuromyths educators might endorse. The current study examined the awareness and endorsement of neuromyths related to dyscalculia and dyspraxia with 229 educators in the UK. Educators were asked to complete a short online survey that included questions about their awareness of SpLDs and some neuromyths, as well as some background questions. Despite educators being more familiar with dyslexia, they endorsed more neuromyths related to dyslexia than dyscalculia. However, being more familiar with dyslexia and being a maths lead did result in the endorsement of fewer neuromyths. These findings suggest that greater awareness of SpLDs in general might not reduce the endorsements of neuromyths, but that to counter the limited awareness of dyscalculia, educators need information about the cognitive mechanisms of learning in these students.
Revisiting the impact of Health at Every Size® interventions on health and cardiometabolic related outcomes: An updated systematic review with meta‐analysis
Authors: Clarke Erin D. , Stanford Jordan , Gomez‐Martin Maria , Collins Clare E. 
Published: April 2024

AbstractAimsTo (1) synthesise evidence from Health at Every Size® interventions on physical and psychological health in people with overweight and obesity and (2) report between‐group differences within interventions evaluating the impact of Health at Every Size® interventions on health and health‐related outcomes.MethodsSix databases (Medline, Embase, Cochrane, PsychInfo, CINAHL, and Scopus) were searched from inception until November 2022. Included studies were conducted in adults with overweight or obesity, used Health at Every Size®‐based interventions compared with control interventions and reported dietary, physical and/or psychological outcomes, including diet quality, anthropometry, or quality of life. Data on between‐group differences were extracted. Risk of bias was assessed using ROB2. Random‐effects meta‐analyses were undertaken for outcomes with at least three studies reporting the same or comparable data.ResultsFrom 128 studies identified, 19 full‐text articles (10 unique studies, 6 published since 2017), were included. Meta‐analysis found a significant reduction for susceptibility to hunger in Health at Every Size® intervention groups relative to controls (p = 0.005), with no significant difference (p > 0.05) between Health at Every Size® interventions and control groups for anthropometric, psychological or cardiometabolic outcomes (total cholesterol, HDL cholesterol, triglycerides, systolic or diastolic blood pressure).ConclusionHealth at Every Size® interventions had similar results compared with weight‐based interventions on anthropometric outcomes and cardiometabolic outcomes. Health at Every Size® interventions had a significant benefit for reducing susceptibility to hunger. The decision to use a Health at Every Size®‐based intervention should be personalised to individual needs. Further research in more diverse populations is required using standardised outcome measures to facilitate future meta‐analyses.
Simple detection of gluten in commercial gluten‐containing samples with a novel nanoflower electrosensor made of molybdenum disulfide with comparison of the ELISA method
Authors: Salman Fırat , Zengin Adem , Çelik Kazici Hilal 
Published: April 2024

AbstractIn this study, a new electrochemical sensor based on molybdenum disulfide (MoS2) nanoflowers/glassy carbon electrode (GCE was created for the sensitive detection of gluten. The prepared nanocatalysts were characterized using scanning electron microscopy with energy dispersive spectroscopy, x‐ray diffraction, and x‐ray photoelectron spectroscopy. The effects of the prepared nanocatalysts, pH value, and dropping amounts on the results were examined in detail. The electrochemical performance of the developed sensor (MoS2 nanoflowers/GCE) was then evaluated using differential pulse voltammetry, and the sensor was found to have significant electrochemical activity against gluten. A substantial linear connection was observed in the range of 0.5–100 ppm of gluten concentration under optimum experimental circumstances, and the detection limit between peak current and gluten concentration was determined as 1.16 ppm. The findings showed that the MoS2 nanoflowers/GCE gluten sensor has exceptional selectivity and stability. Finally, the generated electrochemical sensor was effectively utilized for gluten detection in commercial gluten‐containing materials with a detection limit of 0.1652 ppm. Thus, the developed MoS2 nanoflowers/GCE sensor offers a potential method for the detection of other molecules and is a promising candidate for gluten detection in commercial samples.
Exploitation of Aureobasidium pullulans NRRL Y‐2311‐1 xylanase in mulberry and rice flours–based gluten‐free cookie formulation: Effects on dough properties and cookie characteristics
Authors: Yegin Sirma , Altinel Burak , Tuluk Kubra 
Published: April 2024

AbstractXylanases are mainly utilized in bakery industry for the hydrolysis of dietary fiber–based fractions. Their applications in gluten‐free products have not been considered before. In the present study, the xylanase produced by Aureobasidium pullulans NRRL Y‐2311‐1 was utilized in a mulberry and rice flours–based gluten‐free cookie formulation for the first time. Effects of various xylanase concentrations on gluten‐free dough rheology and cookie characteristics were elucidated. Only rice flour–based cookie and only wheat flour–based cookie formulations were also prepared as comparison. Incorporation of xylanase into all cookie recipes resulted in softer cookie doughs with lower absolute stickiness. The hardness and absolute stickiness of the cookie doughs prepared by the mixture of mulberry and rice flours decreased by the addition of the enzyme into the formulation in a concentration‐dependent manner. Enzyme concentrations above 100 U/100 g flour did not provide statistically significant further changes on gluten‐free cookie doughs. Incorporation of xylanase into the cookie recipes resulted in increased baking loss and spread ratio in an enzyme concentration–dependent manner for all cookie types. Hardness values of both types of gluten‐free cookies decreased by xylanase incorporation. Different effects on fracturability were observed depending on the cookie type and enzyme concentration. Enzyme concentration of 100 U/100 g flour provided mulberry and rice flours–based cookies with a more flexible and softer structure. No significant effects on color parameters of cookies were observed by xylanase incorporation.
Expression and functional characterization of chimeric recombinant bovine follicle‐stimulating hormone produced in Leishmania tarentolae
Authors: Abreu Cecilia , Grunberg Karin , Bonilla Mariana , Crispo Martina , Pantano Sergio , Jaeschke Julian , Comini Marcelo A. , Bollati‐Fogolín Mariela 
Published: April 2024

AbstractAssisted reproductive techniques are routinely used in livestock species to increase and enhance productivity. Ovarian hyperstimulation is a process that currently relies on administering pituitary‐derived follicle‐stimulating hormone (FSH) or equine chorionic gonadotropin in combination with other hormones to promote the maturation of multiple follicles and thereby achieve superovulation. The use of partially purified preparations of FSH extracted from natural sources is associated with suboptimal and variable results. Recombinant FSH (rFSH) has been produced in a variety of heterologous organisms. However, attaining a bioactive rFSH of high quality and at low cost for use in livestock remains challenging. Here we report the production and characterization of a single chain bovine rFSH consisting of the β‐ and α‐subunit fused by a polypeptide linker (scbFSH) using Leishmania tarentolae as heterologous expression system. This unicellular eukaryote is non‐pathogenic to mammals, can be grown in bioreactors using simple and inexpensive semisynthetic media at 26°C and does not require CO2 or bovine serum supplementation. Stable cell lines expressing scbFSH in an inducible fashion were generated and characterized for their productivity. Different culture conditions and purification procedures were evaluated, and the recombinant product was biochemically and biologically characterized, including bioassays in an animal model. The results demonstrate that L. tarentolae is a suitable host for producing a homogeneous, glycosylated and biologically active form of scbFSH with a reasonable yield.
Exploring the nexus between the standardized nursing terminologies and the unfinished nursing care phenomenon: An empty systematic review
Authors: Bertocchi Luca , Chiappinotto Stefania , Palese Alvisa 
Published: April 2024

AbstractPurposeTo identify and synthesize evidence regarding the documented relationship between the standardized nursing terminologies and the unfinished nursing care phenomenon.Data sourcesA systematic review according to the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines. PubMed, Scopus, and Cumulative Index to Nursing and Allied Health Literature Complete databases were last consulted on November 27, 2023. The review included primary quantitative studies that reported an association between recognized standardized nursing terminologies and unfinished nursing care. Two researchers completedtitle and abstract and full‐text screening.Data synthesisOur search identified 149 citations. A full‐text review of one paper was undertaken. No studies met our inclusion criteria. We report an empty review.ConclusionsStandardized nursing terminologies and Unfinished Care are two sides of the same coin: despite their potential commonalities, no studies have documented their potential links. Digital systems, such as electronic health records and decision support systems, could foster this linkage.Implications for nursing practiceThis review suggests that linking the conceptual frameworks can promote the diffusion of standardized nursing terminologies in clinical practice and increase accuracy in the measurement of Unfinished Care. This synergy could promote the contribution of nursing knowledge to patient care, nursing visibility, and be beneficial to clinical nurses, managers, and healthcare systems to international level.
United Kingdom: Political Developments and Data in 2023
Authors: MIDDLETON ALIA 
Published: April 2024

AbstractThe year 2023 saw more stability in British politics, with new Prime Minister Rishi Sunak seeking to make his mark on the policy agenda with the announcement of five key policy pledges in January. As part of seeking to address these, the government placed an increased emphasis on immigration over the year, particularly in tackling illegal crossings over the English Channel. The government also moved away from its net zero agenda. Despite this, the party's poll position did not improve. New peers were introduced by departing Prime Ministers Johnson and Truss. Boris Johnson also stepped down as a Member of Parliament, and a November Cabinet reshuffle saw former Prime Minister David Cameron re‐enter politics as Foreign Secretary.
Progressive changes in pulmonary gas exchange during invasive respiratory support for COVID‐19 associated acute respiratory failure: A retrospective study of the association with 90‐day mortality
Authors: Konsberg Ylva , Åneman Anders , Olsen Fredrik , Hessulf Fredrik , Nellgård Bengt , Hård af Segerstad Mathias , Dalla Keti 
Published: April 2024

AbstractBackgroundRatio of arterial pressure of oxygen and fraction of inspired oxygen (P/F ratio) together with the fractional dead space (Vd/Vt) provides a global assessment of pulmonary gas exchange. The aim of this study was to assess the potential value of these variables to prognosticate 90‐day survival in patients with COVID‐19 associated ARDS admitted to the Intensive Care Unit (ICU) for invasive ventilatory support.MethodsIn this single‐center observational, retrospective study, P/F ratios and Vd/Vt were assessed up to 4 weeks after ICU‐admission. Measurements from the first 2 weeks were used to evaluate the predictive value of P/F ratio and Vd/Vt for 90‐day mortality and reported by the adjusted hazard ratio (HR) and 95% confidence intervals [95%CI] by Cox proportional hazard regression.ResultsAlmost 20,000 blood gases in 130 patients were analyzed. The overall 90‐day mortality was 30% and using the data from the first ICU week, the HR was 0.85 [0.77–0.94] for every 10 mmHg increase in P/F ratio and 1.61 [1.20–2.16] for every 0.1 increase in Vd/Vt. In the second week, the HR for 90‐day mortality was 0.82 [0.75–0.89] for every 10 mmHg increase in P/F ratio and 1.97 [1.42–2.73] for every 0.1 increase in Vd/Vt.ConclusionThe progressive changes in P/F ratio and Vd/Vt in the first 2 weeks of invasive ventilatory support for COVID‐19 ARDS were significant predictors for 90‐day mortality.
Comparative ultrastructure of the olfactory system in the East African root rat (Tachyoryctes splendens) and the naked mole rat (Heterocephalus glaber)
Authors: Onyono P. N. , Kavoi B. M. , Kiama S. G. , Makanya A. N. 
Published: April 2024

AbstractThe ultrastructure of the olfactory system of most fossorial rodents remains largely unexplored. This study sought to investigate the functional structure of the olfactory mucosa and olfactory bulb of two species of fossorial rodents that have distinct behaviour and ecology, the East African root rat (RR) and the naked mole rat (NMR). Transmission electron microscopy and scanning electron microscopy were employed. The basic ultrastructural design of the olfactory system of the two species was largely comparable. In both species, the olfactory mucosa comprised an olfactory epithelium and an underlying lamina propria. The olfactory epithelium revealed olfactory knobs, cilia and microvilli apically and sustentancular cells, olfactory receptor neurons and basal cells in the upper, middle and basal zones, respectively. The lamina propria was constituted by Bowman's glands, olfactory nerve bundles and vasculature supported by loose connective tissue. Within the olfactory bulb, intracellular and extracellular structures including cell organelles, axons and dendrites were elucidated. Notable species differences were observed in the basal zone of the olfactory epithelium and on the luminal surface of the olfactory mucosa. The basal zone of the olfactory epithelium of the RR consisted of a single layer of flattened electron‐dense horizontal basal cells while the NMR had juxtaposed electron‐dense and electron‐lucent heterogenous cells, an occurrence seen as being indicative of quiescent and highly proliferative states of the olfactory epithelia in the two species, respectively. The olfactory epithelial surface of the NMR comprised an elaborate cilia network that intertwined extensively forming loop‐like structures whereas in the RR, the surface was rugged and consisted of finger‐like processes and irregular masses. With gross and histological studies showing significant differences in the olfactory structures of the two species, these findings are a further manifestation that the olfactory system of the RR and the NMR have evolved differently to reflect their varied olfactory functional needs.
Testicular sperm retrieval for intracytoplasmic sperm injection: when to consider it after unsuccessful intracytoplasmic sperm injection with ejaculated sperm?
Authors: Ibis Muhammed Arif , Ozdemir Eda Ureyen , Obaid Khaled , Akpinar Cagri , Ozmen Batuhan , Aydos Kaan , Yaman Onder 
Published: April 2024

AbstractBackgroundThe question of whether patients are more likely to succeed with testicular sperm intracytoplasmic sperm injection (T‐ICSI) after unsuccessful ICSI with ejaculated sperm (Ej‐ICSI) remains unknown.ObjectiveThe study aimed to identify potential predictors of successful T‐ICSI in men with idiopathic infertility and oligozoospermia (sperm concentration < 15 × 106/mL, non‐azoospermic) who had previously experienced unsuccessful Ej‐ICSI.Materials and methodsIn total, 154 couples with male partners who had oligozoospermic conditions after two unsuccessful cycles of Ej‐ICSI switched to T‐ICSI. Before initiating T‐ICSI, the sperm DNA fragmentation index (DFI) was assessed in ejaculated specimens. Participants were divided into two groups: group A (live birth (+), n = 60) and group B (live birth (−), n = 94).ResultsFertilization, clinical pregnancy, live births, and miscarriages had rates of 72.7%, 44.2%, 39%, and 5.2%, respectively. The total motile sperm (TMS) count in group A was significantly higher (3.8 ± 1.5 million) than in group B (3 ± 1.6 million; p = 0.002). DFI was significantly higher in group A (24.2 ± 12.3) than in group B (18.1 ± 11; p = 0.001). Hormone levels and oocyte counts showed no statistically significant differences between groups. Multivariate regression analysis revealed that TMS (odds ratio [OR]: 1.46; 95% CI, 1.14–1.87, p = 0.003) and DFI (OR: 1.04; 95% CI, 1.01–1.08, p = 0.009) were found to be significant predictors of live birth outcomes. At a cutoff point of 2.55 (area under the curve [AUC] = 0.65), the optimal sensitivity and specificity values for TMS were 78% and 48%, respectively. At a cutoff point of 25.8 (AUC = 0.65), DFI had a maximum sensitivity of 51.7% and a specificity of 78.7%.ConclusionsTMS and DFI were found to be significant predictors of live birth outcomes in couples with oligozoospermic male partners undergoing T‐ICSI. These findings may help clinicians tailor treatment strategies for this specific patient population.
Clinical significance of R‐wave amplitude in lead V1 and inferobasal myocardial infarction in patients with inferior wall myocardial infarction
Authors: Zheng Xiao‐Bin , Wu Hai‐Yan , Zhang Ming , Yao Bing‐Qi 
Published: April 2024

AbstractObjectiveTo assess electrocardiogram (ECG) for risk stratification in inferior ST‐elevation myocardial infarction (STEMI) patients within 24 h.MethodsThree hundred thirty‐four patients were divided into four ECG‐based groups: Group A: R V1 <0.3 mV with ST‐segment elevation (ST↑) V7–V9, Group B: R V1 <0.3 mV without ST↑ V7–V9, Group C: R V1 ≥0.3 mV with ST↑ V7–V9, and Group D: R V1 ≥0.3 mV without ST↑ V7–V9.ResultsGroup A demonstrated the longest QRS duration, followed by Groups B, C, and D. ECG signs for right ventricle (RV) infarction were more common in Groups A and B (p < .01). ST elevation in V6, indicative of left ventricle (LV) lateral injury, was more higher in Group C than in Group A, while the ∑ST↑ V3R + V4R + V5R, representing RV infarction, showed the opposite trend (p < .05). The estimated LV infarct size from ECG was similar between Groups A and C, yet Group A had higher creatine kinase MB isoform (CK‐MB; p < .05). Cardiac troponin I (cTNI) was higher in Groups A and C than in B and D (p < .05 and p = .16, respectively). NT‐proBNP decreased across groups (p = .20), with the highest left ventricular ejection fraction (LVEF) observed in Group D (p < .05). Group A notably demonstrated more cardiac dysfunction within 4 h post‐onset.ConclusionsFor inferior STEMI patients, concurrent R V1 <0.3 mV with ST↑ V7–V9 suggests prolonged ventricular activation and notable myocardial damage. RV infarction's dominance over LV lateral injury might explain these observations.
On‐ and off‐the‐job embeddedness differentially shape stress‐related reactions to job insecurity
Authors: Porter Caitlin M. , Peltokorpi Vesa , Allen David G. 
Published: April 2024

AbstractThe prevalence of job insecurity is increasing due to technological, geopolitical, and environmental changes worldwide, leading to negative stress‐related reactions and health outcomes for employees and productivity loss for organizations. Despite these consequences, few recommendations exist for how people can effectively cope with perceived job insecurity to mitigate stress‐related reactions. Drawing from resource‐based stress theories, we highlight job embeddedness, which captures contextual resources derived from on‐the‐job and off‐the‐job domains, as a key factor shaping employee's stress‐related reactions to job insecurity. Data collected at three time points over 12 months from 483 employees in various organizations in Japan reveals that on‐the‐job embeddedness exacerbates the positive relationships of job insecurity with both emotional exhaustion and chronic insomnia, whereas off‐the‐job embeddedness mitigates these associations. This study contributes to the literature by identifying off‐the‐job embeddedness as a bundle of contextual resources that helps employees cope with perceived job insecurity and demonstrating the contrasting effects of the two dimensions of embeddedness in shaping health‐related consequences of job insecurity.
She made it with her friend: How social object history influences children's thinking about the value of digital objects
Authors: Price Keiana , DeJesus Jasmine M. , Nancekivell Shaylene E. 
Published: April 2024

AbstractTwo studies examine how social object histories from collaborative experiences influenced North American children (N = 160, 5–10 years) thinking about the value of digital objects (48% male/51% female; 51% White/24% Black/11% Asian). With forced‐choice judgments, Study 1 found (moderate–large effects) that children viewed digital and physical objects with social histories as more special than objects without such histories. On a 10‐point scale, Study 2 found (large effects) that children rated digital objects with positive social histories as more special than objects with negative ones. Overall, the studies found that children's tendencies to use object history to understand object value extends into digital contexts. They also reveal how an unexplored kind of history—social history—affects judgments.
Clinical, onychoscopic, nail clipping, and histopathological findings of malignant onychopapilloma
Authors: Haynes Dylan , Haneke Eckart , Rubin Adam I. 
Published: April 2024

AbstractThis report describes the clinical, onychoscopic, nail clipping, and histopathologic features of a malignant onychopapilloma. A 71‐year‐old male presented to our outpatient clinic for a stable, asymptomatic lesion on his left middle finger that had been present for 2 years. Prior nail clipping histopathology showed nail plate thinning with subungual abnormal onychocytes. Clinical examination revealed a 2‐mm‐wide streak of longitudinal xanthonychia extending to the proximal nail fold, with distal hyperkeratosis and onycholysis. Onychoscopy showed irregular longitudinal nail plate ridging with scattered punctate hemorrhagic foci. An excisional nail unit biopsy demonstrated cellular atypia of the nail bed epithelium, matrix metaplasia, longitudinal abnormal onychocytes, increased Ki‐67 staining, and negative HPV immunoperoxidase staining, confirming the diagnosis of malignant onychopapilloma.