bluuebunny/crossref_metadata_2025_split huggingface dataset:
RAW264.7 hücrelerinde Odoroside A'nın immün transformasyondaki rolü
Authors: Seçer Çelik Fatma , Eroğlu Güneş Canan 
Published: April 2024

Amaç: Makrofajlar bağışıklık sisteminin en önemli unsurlarından biridir ve inflamasyonda ikili rol oynamaktadır. Hem ortamda immün yanıtın oluşumunu hem de baskılanmasını düzenlemektedir. Kanser mikroçevresindeki bu sinyalleme, kanserin ilerlemesini etkiler. Bu kanseri teşvik eden veya kanseri ortadan kaldıran süreç makrofajlar tarafından yönetilmektedir. Proinflamatuar sitokin genlerinin ifadesindeki artış, ortamdaki tümör hücrelerinin baskılanmasını sağlar. Bu çalışmada Odoroside A'nın makrofaj dönüşümüne etkisinin araştırılması amaçlanmıştır.
Gereç ve yöntem: Makrofaj hücrelerinde öldürücü olmayan Odoroside A dozu CCK-8 analizi ile belirlenmiştir. Daha sonra RAW264.7 hücrelerinde sitokin genlerinin ve yüzey belirteçlerinin qRT-PCR kullanılarak gen ekspresyon analizi yapılmıştır. Gen ekspresyonu analizinde anlamlı çıkan sitokinlerin protein düzeyleri ELISA yöntemi kullanılarak incelenmiştir.
Bulgular: Odoroside A, RAW264.7 hücrelerinde IL1 ve IL6 genlerinin ekspresyonunu önemli ölçüde artırırken, IL10 geninin ekspresyonunu önemli ölçüde azaltmıştır. IL4 ve TGFβ gen ifadelerinde anlamlı bir değişiklik olmamıştır. İstatistiksel olarak anlamlı artış gösteren IL1 ve IL6 gen ekspresyonlarının protein düzeyinde de anlamlı düzeyde arttığı belirlenmiştir.
Sonuç: Tüm veriler birlikte değerlendirildiğinde Odoroside A'nın RAW264.7 hücrelerinde proinflamatuar yanıtı arttırdığı, dolayısıyla M1 tip makrofaj dönüşümünü sağladığı gözlenmiştir. Bu, Odoroside A'nın, tümör nişindeki makrofaj aracılı oluşan proinflamatuar ortamın tümörün ortadan kaldırılmasında etkili olabileceğini düşündürmektedir.
Identifying and Predicting Muslim Community Funeral Funding Protocols
Authors: Ashhuri Hassan , Ibrahim Izzul Ismail , Hassan Raini 
Published: April 2024

This research aims to understand funeral poverty among the Muslim community in Malaysia by using Machine Learning algorithms. Generally, funeral poverty in Malaysia can be described as funerals in Malaysia being exorbitantly priced, inflicting a disproportionate amount of financial hardship on the poor. As the death rate continues to climb year after year, we may conclude that funeral fees are an unavoidable risk. This research problem was inspired by Sustainable Development Goal number 1 and 3 where the goal of this initiative is to increase awareness about the need of having funeral expenditures and how to prevent funeral poverty. Previous works have shown promising results. However, they are not conclusive enough as they lack predicting capability that Machine Learning can offer. Selected Machine Learning algorithms such as Decision Tree, Random Forest, and Naïve Bayes were used to classify the people that will go through funeral poverty based on a selected dataset and a survey conducted. The research methodology is as follows: 1. Collecting the data, 2. Pre-Process the data, 3. Exploratory data analysis, 4. Selecting the feature, 5. Modeling, 6. Evaluation. The results showed that the accuracy value for the selected algorithm is 0.95, 0.95, and 0.95 for the awareness and 0.8, 0.8, and 0.75 for B40 Status in survey datasets. With a larger taxonomy and more extensive, diverse sets of data, these figures are expected to improve. Linear Regression has been applied to help understand the features of a death rate. Both outcomes serve distinct reasons. Because the individuals who would experience funeral poverty are in lower-income neighborhoods, it was necessary to classify impoverished communities in order to anticipate funeral poverty. Following that, the findings of what causes death to rise aid in understanding how the B40 community has been impacted by funeral poverty. In the future, this study will aid future research on funeral poverty on a larger scale. When the two datasets are integrated rather than separated, better results can be obtained. The accuracy of the findings may also be improved by employing a wider range of Machine Learning methods and deep learning implementation. A more coherent and detailed model for forecasting funeral poverty can be developed.
أثر حسن نية المؤمن له من عدمها على نطاق جزاء البطلان في قانون التأمين العماني (دراسة مقارنة)
Authors: عبدالله بن محمد بن عبدالله الفليتي  , محمد إبراهيم النجاشي  
Published: April 2024

تناول هذا البحث أثر حسن نية المؤمن له من عدمها على نطاق جزاء البطلان في القانون العماني ومقارنته بالقانونين الأردني والمصري، حيث أن المؤمن له هو الطرف الضعيف في عقد التامين، وان عقد التامين يعتبر من عقود الإذعان فلا يستطيع المؤمن له التغيير في بنود العقد، وقد درجت شركات التأمين وبحكم مركزها الاقتصادي المتغلب إلى تضمين وثائق التأمين جزاءات خاصة توقع على المؤمن له إذا ما اخل بالتزاماته العقدية، هذه الجزاءات تعد جزاءات قاسية بالنسبة للمؤمن له فمنها ما يؤدي إلى بطلان العقد إذا ما اخل المؤمن له بالتزامه المتمثل بالإدلاء ببيانات الخطر الجوهرية أو سقوط حق المؤمن له في مبلغ التأمين إذا ما اخل بالتزاماته المتعلقة بالحادث الموجب لدفع مبلغ التأمين أي بالحادث المؤمن منه سواء ما تعلق بالتزامه بالإعلان عن وقوع الحادث والتزامه بتقديم المستندات والأوراق الدالة على وقوع الحادث أو الالتزام المتعلق بعدم إقرار المؤمن له بالمسؤولية عن الحادث، أو وقف حقه بمبلغ التامين، لذلك كان لابد من تصدي التشريعات لهذا الأمر ووضع ضوابط وقيود تضمن حماية المؤمن له من هذه الجزاءات وخاصة إذا ما كان المؤمن له حسن النية، لذلك نجد أن بعض التشريعات قد نصت على التزامات المؤمن له وعلى الجزاءات الخاصة المترتبة على الإخلال بهذه الالتزامات إلا أنها ضبطت الأمر ولم تتركه على إطلاقه حيث ميزت ما بين المؤمن له حسن النية والمؤمن له سيء النية ووفرت للمؤمن له حسن النية حماية اكبر، وفرضت قيود لتطبيق بعض الجزاءات الخاصة ومن أهمها جزاء البطلان الذي يفرض من قبل المؤمن على المؤمن له في عقد التامين.
Marriage Choices and Traditions among the Sri Lankan Migrant Workers in Bahrain
Authors: Mohamed I.M. Aslam  , Iyad M.Y. Eid  , Rohaiza Rokis  
Published: April 2024

Family and marriage in Sri Lanka have endured far-reaching changes in recent decades. Starting with the migration from Sri Lanka, particularly after the 1970s, is one of the contributing factors in such family changes. Given that Sri Lanka has been giving greater importance to family and marriage, the present paper attempts to investigate changes in marriage choices, traditions, and marital relationships due to migration. The qualitative research method was utilized, compiling data through semi-structured interviews with thirty Sri Lankan migrant families using a purposive sampling technique, which was analyzed on a thematic basis. Based on the findings, migration was the cause of change in marital choice and traditions since migrants become economically independent and cherish new cultures. The marriage contracts and couple matching among migrant workers had not been spelt out their ancient traditions of Sri Lanka, which leaned more toward love matches. The study has identified the women who migrated as housemaids had formed families with Pakistani and Indian migrant workers, even accepting religious exogamy after arriving in Bahrain based on self-desire. These migrants concealed their personal choice and married without their parent’s concerns and presence. The present study identified that wedlock without proper documents caused their children to be undocumented. Furthermore, the current study revealed that migrant workers who married other nationalities failed to establish fruitful families as their lives ended in divorce due to the lack of knowledge about marital partners and cohesive relationships with them. These findings are significant because of the dearth of literature on marriage migration among Middle Eastern migrants and the range of post-marriage challenges that migrants face in that particular destination. The information explored enriches the literature with a new sociological and empirical study.
RISKS IDENTIFYING AND ASSESSMENT PECULIARITIES IN BUSINESS PLANNING PROCESS
Authors: Pyliavets Viktor , Yasyshena Valentyna 
Published: April 2024

The scientific article discusses problematic aspects of identifying and assessing risks at the stage of developing business plans. It was determined that changes in the economic environment of enterprises require the formation of new approaches and means of solving economic problems. One of the effective ways to solve this problem is to develop a business plan. This document should be considered both a management tool of the business entity and a means of attracting financing. The specifics of business planning are defined, the main reasons that lead to the development of a business plan are considered.
It is noted that risks are an important element that must be paid attention to in business planning. The interpretation of the term "risk" in the scientific literature is generalized. It was determined that the presence of risk in the business plan is a forming factor of uncertainty. The study points to the presence of risks as a mandatory and undeniable element of enterprise activity in modern conditions. Risk assessment is a mandatory structural element of a typical business plan.
It is indicated that each business plan is individual and unique. It is proposed to detail the risks not in a separate section "Risks", but in the section of the main sections of the business plan: market analysis, marketing plan, organizational plan and management, production plan, financial plan, which will allow group all existing risks, detail them and develop priority measures to neutralize them.
The main types of risks that may arise in the main sections of the business plan are revealed. It was determined that the systematization of types and groups of risks by sections is an important tool for their effective management, because it helps to choose individual approaches to assessment, measurement, forecasting and selection of response measures.
As a result, it is proposed to form an appropriate table of risks and means of their neutralization, which will allow to show the investor or an interested person that the applicant is informed and able to cope with the risks and threats of the project
DEVELOPMENT OF THE VALUE BASE MANAGEMENT CONCEPT AND ITS ROLE IN MAXIMIZING THE VALUE OF THE CORPORATE ENTERPRISE
Authors: Kulish Ganna , Chepka Viktoria , Bystranovska (Lyskovets) Julia 
Published: April 2024

The purpose of the study is to critically review and summarize the main world approaches to building Value Base Management and to substantiate, on this basis, recommendations for its implementation in the domestic practice of financial management. The article describes the evolution of VBM development and conceptual approaches to corporate enterprise management. The objective necessity of transforming approaches to the management of corporate enterprises from traditional financial models to value-based management is substantiated. It is established that VBM is not only one of the main directions of improving the efficiency of management decisions, but also has a significant impact on the value of a corporate enterprise in the long term. The article proves that the use of the value-based concept of enterprise financial management implies the selection of appropriate methods and tools at all levels of management aimed at sustainable value reproduction.
The article considers the process of transformation of the VBM concept and its main elements. A comprehensive analysis of the main approaches and models to business valuation is presented. A comparative characterization of VBM and the traditional approach to corporate enterprise management is systematized and provided.
The generalization of the economic content of management theories has allowed to substantiate that VBM differs significantly from the previously accepted management criteria and is a more effective concept of equity management than other systems. It should be borne in mind that the value of an enterprise, on the one hand, is an indicator of its sustainable development, and on the other hand, it is a regulator of value distribution for various participants in economic relations, so, of course, the management mechanism should focus on the key factors of value creation
An Analysis of Early Childhood Education Teachers' Competencies: A Qualitative Study
Authors: Rakhmania Raisa , Riyanti Benedicta Prihatin Dwi , Purwanti Margaretha 
Published: April 2024

This article reviews research on Indonesian Early Childhood Education (ECE) teachers' pedagogical, personality, social, and professional competency. This study examines four factors of ECE teacher competence as perceived by 45 teachers. This qualitative study uses semi-structured interviews to collect data. Data was analyzed using thematic analysis. The study found that ECE teachers stimulated early childhood development appropriately. The study also revealed several findings, including teachers' limited awareness of early childhood development theories, a lack of understanding of their ethical responsibilities, and various barriers to ECE teacher competence. This qualitative study highlights Indonesian ECE teachers' expertise and pedagogy. These findings can help create more effective and sustainable ECE teacher training programs. This study also encourages reflection on teachers' role in early childhood development and identifies areas that need more attention in Indonesia's early childhood education system.
Pelatihan Microsoft Excel untuk Peningkatan Keterampilan Administrasi Santriwati : Suatu Pendekatan Pengabdian Masyarakat di Pondok Pesantren Kun Sholihan Gunungkidul
Authors: Sholeh Muhammad , Kumalasari Erna , Sutanta Edhy , Erma Susanti  , Ariyana Renna Yanwastika , Saudah Siti 
Published: April 2024

Pelaksanaan pengabdian kepada masyarakat yang dilaksanakan bertujuan untuk meningkatkan keterampilan administrasi santriwati di Pondok Pesantren Kun Sholihan, Gunungkidul. Kegiatan dilakukan melalui pelatihan Microsoft Excel. Microsoft Excel dapat digunakan untuk membantu pengguna dalam membuat, mengorganisir, mengelola, dan menganalisis data menggunakan lembar kerja elektronik. Dengan Microsoft Excel, pengguna dapat membuat tabel, grafik, dan diagram yang memungkinkan pengolahan dan representasi visual data dengan mudah. Pendekatan pengabdian masyarakat digunakan untuk mendesain dan mengimplementasikan program pelatihan yang fokus pada aspek-aspek administrasi, termasuk pengelolaan data, pembuatan laporan, dan analisis keuangan menggunakan Microsoft Excel. Manfaat menguasai Excel, para santri tidak hanya siap untuk kehidupan akademik, tetapi juga terampil dalam mengelola berbagai aspek kehidupan sehari-hari mereka di pesantren dan di masa depan. Metode pelatihan melibatkan sesi interaktif, latihan praktis, dan studi kasus yang relevan dengan kebutuhan administrasi pesantren. Hasil evaluasi menunjukkan peningkatan signifikan dalam keterampilan penggunaan Microsoft Excel di kalangan Santriwati. Para santri dapat membuat laporan keuangan bulanan dengan menggunakan rumus-rumus Excel yang relevan dan memahami cara menganalisis data untuk mendukung pengambilan keputusan administratif. Kesimpulan dari kegiatan ini menunjukkan bahwa pelatihan Microsoft Excel dapat menjadi strategi efektif untuk meningkatkan keterampilan administrasi Santriwati di lingkungan pondok pesantren. Hasil ini memberikan kontribusi positif terhadap kesiapan Santriwati menghadapi tuntutan teknologi dalam dunia kerja modern.
Pelatihan Pembuatan Sosis Ikan Tuna Sirip Kuning (Thunnus albacares) di Kampung Holtekamp, Distrik Muara Tami, Kota Jayapura, Papua
Authors: Indrayani Ervina , Ayer Popi Ida Laila , Bara’padang Barnabas , Rejauw Korinus , Umbekna Sara , Warpur Maklon , Tuhumena Lolita , Gea Liyatin , Mantayborbir Vyona , Tasak Albida Rante , Yenusi Tien Nova  B. , Agamawan Lalu Panji I. , Misbach Imam , Hisyam Muhammad 
Published: April 2024

Pengolahan ikan berpotensi menghasilkan berbagai diversifikasi olahan. Ikan tuna sirip kuning merupakan salah satu ikan yang dapat di olah menjadi sosis ikan, fillet, abon atau produk-produk olahan lainnya. Sosis ikan merupakan produk daging giling yang bersifat kenyal dan berbentuk silinder dengan pembungkus khusus (casing). Target kegiatan pengabdian yaitu ibu-ibu nelayan di Kampung Holtekamp. Ibu-ibu nelayan di Kampung Holtekamp kurang terampil dalam mengolah produk ikan mentah sehingga solusi yang ditawarkan pada ibu-ibu nelayan di Kampung Holtekamp yaitu melakukan pelatihan pembuatan sosis dengan bahan dasar ikan Tuna sirip kuning dengan menggunakan teknologi sederhana dan tepat guna. Lokasi kegiatan pengabdian di Kampung Holtekamp, Distrik Muara Tami Kota Jayapura. Metode yang digunakan untuk menyelesaikan permasalah tersebut yaitu survey, wawancara, penyuluhan dan pelatihan. Hasil kegiatan yang dilakukan yaitu Melalui kegiatan pengabdian kepada masyarakat ini ibu-ibu nelayan di kampung Holtekamp mendapatkan pengetahuan baru tentang pembuatan sosis ikan tuna sirip kuning. Selain itu oleh Sekretaris kampung Holtekamp semua peserta dibentuk dalam satu tim pegolah sosis ikan di Kampung Holtekamp.
Освітньо-виховна діяльність у спеціалізованих дитячих художніх закладах Поділля другої половини XX століття
Authors: Зузяк Тетяна , Марущак Оксана , Соловей Віктор , Швець Інна 
Published: April 2024

The article is devoted to the coverage of educational activities in spe­cialized children's art institutions of Podillia in the second half of the twentieth century. Solving the complex tasks of integrating art educa­tion into the European educational space is impossible without a thor­ough study of one's own historical past, familiarization with the legacy of the teachers-artists who stood at the origins of art education in Podil­lia. The problem of educational activities in specialized children's art in­stitutions in Podillіa is quite urgent. In modern society, among educa­tional institutions that perform the educational and educational function of artistic direction at a high level, few can compete with the work of children's art schools. Art education in Podillіa has historical traditions and is important to study. The analysis of archival sources and periodi­cals of the studied period allows us to state that only from the second half of the XXth century. the first children's art schools appear in Podillіa, in particular Buchachska, Vinnytsia, Kamianets-Podilska, Khmelnytska and Ternopil. Research into the history of practical training in artistic educational institutions of Podillia showed that drawing, painting, com­position, sculpture, art history were key and were studied in all schools, which means that regardless of the settlement and the teaching staff, professional training was conducted at a high level. and all schools pro­duced highly qualified pupils and future artists. It has been proven that the main program tasks set by teachers of art schools included learning the basics of fine art, developing spiritual qualities and understanding beauty. The implementation of these tasks took place through tradi­tional and innovative forms and methods of education. Classes in the subjects «drawing», «painting», «composition» and «sculpture» were classes of artistic research, because the students acquired not only pro­fessional skills, but first of all, learned to think outside the box and fan­tasize. An equally important task for teachers of art schools was the de­velopment of imagination, creative thinking, visual memory of students, using a variety of art materials and techniques. It has been proven that the system of consistent development of art education was laid as the basis of education in schools, namely, the foundation was laid for the successive transmission of the traditions of a realistic depiction of the world to future generations, and the implementation of pre-professional training. It is proven that the main principle of the educational process – the unity of learning and creativity – was formed in the period under con­sideration. We consider the analysis of the formation and development of professional art education in Podillіа to be a perspective for further research.
Endoscopic transorbital approach bone pillars: a comprehensive stepwise anatomical appraisal
Authors: Codes Marta , Mosteiro Alejandra , Tafuto Roberto , Gomez Lorena , Matas Jessica , Alobid Isam , Lopez Mauricio , Prats-Galino Alberto , Enseñat Joaquim , Di Somma Alberto 
Published: April 2024

OBJECTIVE
The endoscopic superior eyelid transorbital approach has garnered significant consideration and gained popularity in recent years. Detailed anatomical knowledge along with clinical experience has allowed refinement of the technique as well as expansion of its indications. Using bone as a consistent reference, the authors identified five main bone pillars that offer access to the different intracranial targeted areas for different pathologies of the skull base, with the aim of enhancing the understanding of the intracranial areas accessible through this corridor.

METHODS
The authors present a bone-oriented review of the anatomy of the transorbital approach in which they conducted a 3D analysis using Brainlab software and performed dry skull and subsequent cadaveric dissections.

RESULTS
Five bone pillars of the transorbital approach were identified: the lesser sphenoid wing, the sagittal crest (medial aspect of the greater sphenoid wing), the anterior clinoid, the middle cranial fossa, and the petrous apex. The associations of these bone targets with their respective intracranial areas are reported in detail.

CONCLUSIONS
Identification of consistent bone references after the skin incision has been made and the working space is determined allows a comprehensive understanding of the anatomy of the approach in order to safely and effectively perform transorbital endoscopic surgery in the skull base.
Endoscopic transorbital approach in children: surgical technique and early results
Authors: Jeon Chiman , Chong Kyuha , Shin Hyung Jin , Kong Doo-Sik 
Published: April 2024

OBJECTIVE
In this study, the authors aimed to describe the endoscopic transorbital approach (ETOA) in children.

METHODS
Six pediatric patients (2 girls and 4 boys) underwent the ETOA for paramedian skull base lesions at a single institution between September 2016 and February 2023.

RESULTS
The median age at the time of surgery was 7.5 (range 4–18) years. The median follow-up period was 33 (range 9–60) months. In this series, the ETOA level of difficulty included stage 1 (n = 2, 33.3%), stage 3 (n = 3, 50%), and stage 5 (n = 1, 16.7%). The ETOA was performed for tumor resection in 4 cases; the final pathology consisted of fibrous dysplasia, pilocytic astrocytoma, metastatic neuroblastoma, and choroid plexus papilloma. The procedure was also performed for repair of a petrous apex meningocele and for lateral orbital wall decompression of traumatic lateral rectus muscle entrapment. One patient experienced a transient cranial nerve III palsy after the procedure. There were no operative deaths in this series.

CONCLUSIONS
In select cases, the ETOA can be considered a minimally invasive alternative for conventional skull base approaches in the armamentarium of pediatric skull base surgery. Further investigation and the accumulation of experience are warranted in the future to enhance the efficacy and applicability of the ETOA in pediatric patients.