bluuebunny/crossref_metadata_2025_split huggingface dataset:
Artificial Intelligence and English Classroom: The Implications of AI Toward EFL Students’ Motivation
Authors: Moybeka Adolfina M. S. , Syariatin Nur , Tatipang Devilito P. , Mushthoza Dina Amaliyah , Dewi Ni Putu Juliani Lestari , Tineh Sulfany 
Published: March 2024

The integration of Artificial Intelligence (AI) into the realm of English as a Foreign Language (EFL) education has brought forth transformative possibilities, particularly in the context of student motivation. This research employs a mixed-methods approach, encompassing quantitative surveys and qualitative study of previous literature, to delve into the multifaceted dimensions of EFL students' motivation within the AI-driven learning environment. Quantitative data collection involves administering structured survey questionnaires to a diverse group of EFL students who have experienced AI-based language learning tools. Qualitative insights are gleaned through document/literature study, aiming to provide in-depth narratives and understandings concerning the participants' experiences, attitudes, and perceptions regarding AI in EFL classroom. This integration highlights the nuanced interplay between AI technologies and motivation factors, shedding light on how AI can enhance intrinsic motivation, boost self-efficacy, and facilitate personalized language learning experiences. Moreover, the study addresses ethical considerations, ensuring the privacy and well-being of participants throughout the research process. Ultimately, the research contributes to the growing body of knowledge on AI's role in education and its potential to shape the future of EFL instruction. By unveiling the implications of AI on EFL students' motivation, this study provides valuable insights for educators, policymakers, and stakeholders, guiding the effective integration of AI to foster enduring and enthusiastic language learners in an increasingly digital age.
Learning Management In Increasing Students' Learning Motivation At Ma Karya Bakti Sukasari Kertasari Bandung District
Authors: Ahadiat Ahadiat , Rusmana Jajang , Defauzi Prisna , Rostini Deti , Mastiani Emay 
Published: March 2024

Latar belakang penelitian ini adalah banyaknya peserta didik yang motivasi belajarnya kurang karena disebabkan beberapa faktor salah satunya yaitu faktor lingkungan, kurangnya motivasi belajar dalam diri peserta didik, peserta didik tidak menyukai mata pelajaran tertentu, dan pengaruh perkembangan teknologi yang tidak dimanfaatkan dengan baik yang menyebabkan peserta didik malas dalam belajar dan prestasi belajar menurun. Penelitian ini bertujuan untuk mendeskripsikan manajemen pembelajaran dalam meningkatkan motivasi belajar peserta didik. Penelitian ini menggunakan metode kualitatif deskriptif. Subjek dalam penelitian ini adalah manajemen pembelajaran, motivasi belajar, dan peserta didik. Deskripsi hasil penelitian disajikan dalam uraian kata-kata. Hasil penelitian menunjukan bahwa manajemen pembelajaran dalam meningkatkan motivasi belajar peserta didik di MA Karya Bakti telah melakukan manajemen pembelajaran secara umum dibuktikan dengan membuat perencanaan, pengorganisasian, pelaksanaan, dan evaluasi. Adapun kendala yang ditemukan dalam pelaksanaan, salah satunya ada saja guru yang tidak membuat RPP terbaru tetapi menggunakan yang sebelumnya, juga berkaitan kendala benda dan sarana prasarana yang masih kurang.
The Influence of the Flipped Learning Model on Creative Thinking Ability in the Revolution 4.0 era
Authors: Harso Aloisius , Amri Miftachul , Susiloningtyas Riyanti , Sanulita Henny , Widodo Hadi , Santosa Tomi Apra 
Published: March 2024

Many applications of flipped learning have a huge impact on students' creative thinking ability in learning. However, no deep conclusions have been found and are still subjective. This study aims to determine the influence of flipped learning to improve students' creative thinking skills in the era of the industrial revolution 4.0. This type of research is a meta-analysis. The research data came from google scholar, Researchgaet, ScienceDirect and ERIC. The inclusion criteria in this study are research from SINTA and Scopus indexed journals; Research must be experimental or quasi-experimental; Research related to flipped learning models on students' creative thinking skills; Research published in 2020-2024; The study must have complete data to calculate the value of effect size; sample size (N) > 25 students. The results of the analysis of 15 journals concluded that there was a significant influence on students' creative thinking ability with a high mean effect size (ES = 1.12) criterion. These findings explain the application of flipped learning effectively helps teachers and students in improving creative thinking skills in the learning process.
Implementation of Classical Format Intelligent Character Education (PKC-KA) to Reduce Student Academic Procrastination
Authors: Asbi Asbi , Hasibuan M Fauzi , Sari Mawar 
Published: March 2024

Prokrastinasi akademik merupakan salah satu permasalah yang sering terjadi, terutama dibidang akademik. Prokrastinasi akademik dapat didefinisikan sebagai kecenderungan seseorang dalam menunda kegiatan yang berkaitan dengan akademik. Salah satu penyebab terjadinya prokrastinasi pada siswa yaitu rasa malas dan tidak memahami tugas yang diberikan oleh guru. Salah satu perilaku siswa yang mengarah kepada prokrastinasi akademik adalah tidak megumpulkan tugas sekolah sesuai waktu yang telah ditentukan sebelumnya. Sampel penelitian ini adalah siswa kelas X-IPS 1 dan X-IPS 2 MAN 1 Batubara dengan kelompok eksperimen sebanyak 32 orang siswa dan kelompok kontrol sebanyak 32 orang siswa. Instrumen penelitian yang digunakan adalah model Skala Likert, selanjutnya akan dianalisis menggunakan uji Wilcoxon Signed Ranks Test dan uji Kolmogorov-Smirnov Two Independent Sampel dengan bantuan SPSS versi 26.00. Temuan penelitian ini secara umum menunjukkan bahwa pendidikan karakter cerdas format klaskal (PKC-Ka) efektif untuk mengurangi prokrastinasi akademik pada siswa sehingga untuk selanjutnya dapat diberikan kepada siswa dalam upaya mengurangi prokrastinasi akademik siswa. Selanjutnya, temuan penelitian secara khusus yaitu: (1) terdapat perbedaan yang signifikan prokrastinasi akademik mahasiswa pada kelompok eksperimen sebelum dan setelah diberikan pendidikan karakter cerdas format klaskal (PKC-Ka), (2) terdapat perbedaan prokrastinasi akademik mahasiswa pada kelompok kontrol sebelum dan setelah diberikan informasi konvensional dan (3) terdapat perbedaan prokrastinasi akademik siswa antara kelompok eksperimen yang diberikan pendidikan karakter cerdas format klaskal (PKC-Ka) dengan kelompok kontrol yang diberikan layanan informasi konvensional
Utilizing GO/PEDOT:PSS/PtNPs-enhanced high-stability microelectrode arrays for investigating epilepsy-induced striatal electrophysiology alterations
Authors: Han Meiqi , Wang Yu , Jing Luyi , Yang Gucheng , Liu Yaoyao , Mo Fan , Xu Zhaojie , Luo Jinping , Jia Qianli , Zhu Yuxin , Cao Hanwen , Cai Xinxia , Liu Juntao 
Published: March 2024

The striatum plays a crucial role in studying epilepsy, as it is involved in seizure generation and modulation of brain activity. To explore the complex interplay between the striatum and epilepsy, we engineered advanced microelectrode arrays (MEAs) specifically designed for precise monitoring of striatal electrophysiological activities in rats. These observations were made during and following seizure induction, particularly three and 7 days post-initial modeling. The modification of graphene oxide (GO)/poly (3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS)/platinu-m nanoparticles (PtNPs) demonstrated a marked reduction in impedance (10.5 ± 1.1 kΩ), and maintained exceptional stability, with impedance levels remaining consistently low (23 kΩ) even 14 days post-implantation. As seizure intensity escalated, we observed a corresponding increase in neuronal firing rates and local field potential power, with a notable shift towards higher frequency peaks and augmented inter-channel correlation. Significantly, during the grand mal seizures, theta and alpha bands became the dominant frequencies in the local field potential. Compared to the normal group, the spike firing rates on day 3 and 7 post-modeling were significantly higher, accompanied by a decreased firing interval. Power in both delta and theta bands exhibited an increasing trend, correlating with the duration of epilepsy. These findings offer valuable insights into the dynamic processes of striatal neural activity during the initial and latent phases of temporal lobe epilepsy and contribute to our understanding of the neural mechanisms underpinning epilepsy.
Synced ads: effects of mobile ad size and timing
Authors: Brechman Jean M. , Varan Duane , Wooley Brooke , Bellman Steven 
Published: March 2024

IntroductionSynced ads differ from other forms of targeted advertising on mobile devices because they target concurrent media usage rather than location or predicted interest in the brand. For example, a TV-viewer’s smartphone could listen to the ads playing on the TV set and show matching social media ads. These social media ads could be timed to appear simultaneously with the TV ad, or shortly before or after.MethodsThis research reports a meta-analysis (N = 980) of four lab studies that used representative samples of consumers and realistic manipulations of synced ads. These studies contrasted with most previous studies of synced ads, which have used student samples and unrealistic manipulations or imagined scenarios, which means little is known about whether or why synced ads are effective in real life. These four studies manipulated the effects of synced-ad timing (simultaneous vs. sequential before or after) and the size of the mobile ad, to see if these moderate the effects of synced ads.ResultsThe results showed that synced ads were more effective, measured by unaided brand recall, when they were shown after the TV commercial, rather than simultaneously. Ad size had no moderating effect, which suggests that normal ads can be used, rather than the full-screen or pop-up ads used in previous studies. A final study, in which ad timing was user-controlled, rather than advertiser-controlled, showed that precise timing is not important for synced-ad effectiveness.DiscussionThese results suggest the effects of synced ads are best explained by repetition rather than synergy between the two exposures. There were no significant effects on brand attitude, ad liking, or purchase intention. These results have implications for theoretical models of synced-ad effectiveness, and for advertisers planning to use synced ads.
Temporal analysis of the state of the Gbele Resource Reserve in the Upper West Region, Ghana
Authors: Aabeyir Raymond , Peprah Kenneth , Amponsah Amos 
Published: March 2024

IntroductionThis paper assessed the changes in the forest cover of the Gbele Resource Reserve from 1990 to 2020. This provides a basis for strengthening management decisions to protect the resources in the Gbele Resource Reserve effectively.MethodsLandsat images for 1990, 2000, 2010 and 2020 were obtained from the United States Geological Service site. They were processed and classified in the System for Earth Observation Data Access, Processing, &amp; Analysis for Land Monitoring (SEPAL), a web-based cloud computing platform. The accuracy of the images was assessed using 50 ground-truth points obtained from the 3-5 meter spatial and near-daily temporal resolution planet satellite images from Norway’s International Climate and Forest Initiative (NICFI). Post classification change detection was used to analyse the changes in land cover from 1990 to 2000, 2000 to 2010 and from 2010 to 2020.ResultsThe analysis revealed that the total forest area was 55273.2 ha. In 1990, 74.9 % of the reserve was open forest and 24.6 % was shrubs/grass. The open forest declined to 65.8 % in 2000 and further to 62.4 % in 2010 while the shrubs/grass cover increased to 35.7 in 2010. As of 2020, the forest increased to 73.6 % while the shrub/grass cover declined to 25.8 %.DiscussionThese changes could be attributed partly to widespread charcoal production in the fringe districts and rose wood harvesting in the early 2000s. charcoal production and rosewood logging have been livelihood sources for fringe communities. The ban on the harvest and exportation of rosewood after 2010 could partly explain the sharp increase in the open forest cover from 2010 to 2020. The changes in the extent of the reserve from 1990 to 2020 revealed that the reserve can vulnerable to excessive exploitation and can also be resilient if deliberate efforts are made to protect it. It is recommended that the fringe district and municipal Assemblies should strengthen the enforcement of the ban on the logging of the rosewood and trees in the reserve for the production of charcoal.
Deletion of the Mycobacterium tuberculosis cyp138 gene leads to changes in membrane-related lipid composition and antibiotic susceptibility
Authors: Lu Yun , Chen Hongtong , Shao Zhiyuan , Sun Lang , Li Congran , Lu Yu , You Xuefu , Yang Xinyi 
Published: March 2024

IntroductionMycobacterium tuberculosis (Mtb), the main cause of tuberculosis (TB), has brought a great burden to the world's public health. With the widespread use of Mtb drug-resistant strains, the pressure on anti-TB treatment is increasing. Anti-TB drugs with novel structures and targets are urgently needed. Previous studies have revealed a series of CYPs with important roles in the survival and metabolism of Mtb. However, there is little research on the structure and function of CYP138.MethodsIn our study, to discover the function and targetability of CYP138, a cyp138-knockout strain was built, and the function of CYP138 was speculated by the comparison between cyp138-knockout and wild-type strains through growth curves, growth status under different carbon sources, infection curves, SEM, MIC tests, quantitative proteomics, and lipidomics.Results and discussionThe knockout of cyp138 was proven to affect the Mtb's macrophage infection, antibiotics susceptibility, and the levels of fatty acid metabolism, membrane-related proteins, and lipids such as triacylglycerol. We proposed that CYP138 plays an important role in the synthesis and decomposition of lipids related to the cell membrane structure as a new potential anti-tuberculosis drug target.
Cross-validation of chemical and genetic disruption approaches to inform host cellular effects on Wolbachia abundance in Drosophila
Authors: Sharmin Zinat , Samarah Hani , Aldaya Bourricaudy Rafael , Ochoa Laura , Serbus Laura Renee 
Published: March 2024

IntroductionEndosymbiotic Wolbachia bacteria are widespread in nature, present in half of all insect species. The success of Wolbachia is supported by a commensal lifestyle. Unlike bacterial pathogens that overreplicate and harm host cells, Wolbachia infections have a relatively innocuous intracellular lifestyle. This raises important questions about how Wolbachia infection is regulated. Little is known about how Wolbachia abundance is controlled at an organismal scale.MethodsThis study demonstrates methodology for rigorous identification of cellular processes that affect whole-body Wolbachia abundance, as indicated by absolute counts of the Wolbachia surface protein (wsp) gene.ResultsCandidate pathways, associated with well-described infection scenarios, were identified. Wolbachia-infected fruit flies were exposed to small molecule inhibitors known for targeting those same pathways. Sequential tests in D. melanogaster and D. simulans yielded a subset of chemical inhibitors that significantly affected whole-body Wolbachia abundance, including the Wnt pathway disruptor, IWR-1 and the mTOR pathway inhibitor, Rapamycin. The implicated pathways were genetically retested for effects in D. melanogaster, using inducible RNAi expression driven by constitutive as well as chemically-induced somatic GAL4 expression. Genetic disruptions of armadillo, tor, and ATG6 significantly affected whole-body Wolbachia abundance.DiscussionAs such, the data corroborate reagent targeting and pathway relevance to whole-body Wolbachia infection. The results also implicate Wnt and mTOR regulation of autophagy as important for regulation of Wolbachia titer.
Integrated 16S rRNA sequencing and metagenomics insights into microbial dysbiosis and distinct virulence factors in inflammatory bowel disease
Authors: Wang Haijing , Wang Yuanjun , Yang Libin , Feng Jiawen , Tian Shou , Chen Lingyan , Huang Wei , Liu Jia , Wang Xiaojin 
Published: March 2024

IntroductionThe escalation of urbanization correlates with rising rates of inflammatory bowel disease (IBD), necessitating research into new etiological factors. This study aims to elucidate the gut microbiota profiles in IBD patients and compare them with healthy controls in a western city of China.MethodsWe conducted a multicenter case-control study from the end of 2020, using 16S rRNA gene sequencing (n = 36) and metagenomic sequencing (n = 12) to analyze the gut microbiota of newly diagnosed IBD patients, including those with Crohn's disease (CD) and ulcerative colitis (UC).ResultsOur results demonstrated a significant enrichment of the phylum Proteobacteria, particularly the genus Escherichia-Shigella, in CD patients. Conversely, the genus Enterococcus was markedly increased in UC patients. The core gut microbiota, such as the Christensenellaceae R-7 group, Fusicatenibacter, and Holdemanella, were primarily identified in healthy subjects. Additionally, significant interactions between the microbiome and virulence factors were observed.DiscussionThe findings suggest that oxidative stress may play a pivotal role in the pathology of IBD. This study contributes to the growing dialogue about the impact of gut microbiota on the development of IBD and its variations across different geographies, highlighting potential avenues for further research.
Clinical utility of plasma Aβ42/40 ratio by LC-MS/MS in Alzheimer’s disease assessment
Authors: Weber Darren M. , Taylor Steven W. , Lagier Robert J. , Kim Jueun C. , Goldman Scott M. , Clarke Nigel J. , Vaillancourt David E. , Duara Ranjan , McFarland Karen N. , Wang Wei-en , Golde Todd E. , Racke Michael K. 
Published: March 2024

IntroductionPlasma Aβ42/40 ratio can help predict amyloid PET status, but its clinical utility in Alzheimer’s disease (AD) assessment is unclear.MethodsAβ42/40 ratio was measured by LC-MS/MS for 250 specimens with associated amyloid PET imaging, diagnosis, and demographic data, and for 6,192 consecutive clinical specimens submitted for Aβ42/40 testing.ResultsHigh diagnostic sensitivity and negative predictive value (NPV) for Aβ-PET positivity were observed, consistent with the clinical performance of other plasma LC-MS/MS assays, but with greater separation between Aβ42/40 values for individuals with positive vs. negative Aβ-PET results. Assuming a moderate prevalence of Aβ-PET positivity, a cutpoint was identified with 99% NPV, which could help predict that AD is likely not the cause of patients’ cognitive impairment and help reduce PET evaluation by about 40%.ConclusionHigh-throughput plasma Aβ42/40 LC-MS/MS assays can help identify patients with low likelihood of AD pathology, which can reduce PET evaluations, allowing for cost savings.
Optimal dose of fenfluramine in adjuvant treatment of drug-resistant epilepsy: evidence from randomized controlled trials
Authors: Xu Yingchun , Chen Deng , Liu Ling 
Published: March 2024

ObjectiveSeveral clinical trials have suggested that fenfluramine (FFA) is effective for the treatment of epilepsy in Dravet syndrome (DS) and Lennox–Gastaut syndrome (LGS). However, the exploration of its optimal target dose is ongoing. This study aimed to summarize the best evidence to inform this clinical issue.Materials and methodsWe searched PubMed, Embase (via Ovid), and Web of Science for relevant literature published before December 1st, 2023. Randomized, double-blind, placebo-controlled studies that evaluated the efficacy, safety, and tolerability of FFA in DS and LGS were identified and meta-analysis was performed according to doses. The study was registered with PROSPERO (CRD42023392454).ResultsSix hundred and twelve patients from four randomized controlled trials were enrolled. The results demonstrated that FFA at 0.2, 0.4, or 0.7 mg/kg/d showed significantly greater efficacy compared to placebo in terms of at least 50% reduction (p &lt; 0.001, p &lt; 0.001, p &lt; 0.001) and at least 75% reduction (p &lt; 0.001, p = 0.007, p &lt; 0.001) in monthly seizure frequency from baseline. Moreover, significantly more patients receiving FFA than placebo were rated as much improved or very much improved in CGI-I by both caregivers/parents and investigators (p &lt; 0.001). The most common treatment-emergent adverse events were decreased appetite, diarrhea, fatigue, and weight loss, with no valvular heart disease or pulmonary hypertension observed in any participant. For dose comparison, 0.7 mg/kg/d group presented higher efficacy on at least 75% reduction in seizure (p = 0.006) but not on at least 50% reduction. Weight loss (p = 0.002), decreased appetite (p = 0.04), and all-cause withdrawal (p = 0.036) were more common in 0.7 mg/kg/d group than 0.2 mg/kg/d. There was no statistical difference in other safety parameters between these two groups.ConclusionThe higher range of the licensed dose achieves the optimal balance between efficacy, safety, and tolerability in patients with DS and LGS.Clinical trial registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42023392454.