bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of COVID-19 first wave on the mental health of healthcare workers in a Front-Line Spanish Tertiary Hospital: lessons learned
Authors: Molina Juan D. , Amigo Franco , Vilagut Gemma , Mortier Philippe , Muñoz-Ruiperez Carmen , Rodrigo Holgado Irene , Juanes González Alba , Combarro Ripoll Carolina Elisa , Alonso Jordi , Rubio Gabriel 
Published: April 2024

AbstractHealthcare workers (HCWs) were at high risk of experiencing psychological distress during COVID-19 pandemic. The objective of this study was to evaluate the impact on HCWs’ mental health in a Spanish hospital. Cross-sectional study of HCW, active between May and June 2020. A web-based survey assessed probable current mental disorders (major depressive disorder [PHQ-8 ≥ 10], generalized anxiety disorder [GAD-7 ≥ 10], panic attacks, post-traumatic stress disorder [PTSD; PLC-5 ≥ 7], or substance use disorder [CAGE-AID ≥ 2]). The Sheehan Disability Scale (SDS) was used to assess severe impairment and items taken from the modified self‐report version of the Columbia Suicide Severity Rating Scale (C‐SSRS) assessed suicidal thoughts and behaviors. A total of 870 HCWs completed the survey. Most frequent probable mental disorders were major depressive disorder (33.6%), generalized anxiety disorder (25.5%), panic attacks (26.9%), PTSD (27.2%), and substance use disorder (5.0%). Being female, having aged 18–29 years, being an auxiliary nurse, direct exposure to COVID-19-infected patients, and pre-pandemic lifetime mental disorders were positively associated with mental issues. Hospital HCWs presented a high prevalence of symptoms of mental disorders, especially depression, PTSD, panic attacks, and anxiety. Younger individuals and those with lifetime mental disorders have been more vulnerable to experiencing them.
Aerodynamic performance and wind-induced response of carbon fiber-reinforced polymer (CFRP) cables
Authors: Long Guanxu , Sun Yamin , Shang Zhiqiang , Wang Xiaoyu , Xu Xingwei , Wang Tao 
Published: April 2024

AbstractTo study the aerodynamic performance and wind-induced response of carbon fiber-reinforced polymer (CFRP) cables, CFRP cable was designed by replacing a steel cable in a tied arch bridge based on stiffness, strength and area equivalent criteria, respectively. The aerodynamic performance and wind-induced response of CFRP cable and steel cable were studied and compared by computational fluid dynamics (CFD) model. Based on the computational results, optimal cable replacement criterion was proposed for CFRP cable to replace steel cable. In addition, surface modification was conducted by engrooving vertical symmetric (VS), vertical asymmetric (VA) and helical symmetric (HS) V-shaped grooves to improve the aerodynamic performance and wind-induced response of CFRP cable. Results showed that CFRP cables exhibited inferior aerodynamic performance and wind-induced response in most cases. However, CFRP cable based on stiffness equivalent criterion exhibited better aerodynamic performance and wind-induced vibration properties compared to the other two cable replacement criteria, thus is regarded as the optimal substitute for steel cable. In addition, HS grooves generated symmetric disturbances and caused approximately equivalent boundary layer separation delays uniformly and continuously along the cable length, thus exhibiting better effect in decreasing the reverse flow region, the maximum negative flow velocity, the vortex shedding frequency and the wind-induced vibration amplitude of CFRP cable. Hence, the stiffness equivalent criterion combined with surface modification with HS V-shaped grooves was proposed to replace steel cable with CFRP cable. This study can provide insights into the aerodynamic performance and wind-induced response of CFRP cable and instructions for cable replacement practice.
High microbiome and metabolome diversification in coexisting sponges with different bio-ecological traits
Authors: Mazzella Valerio , Dell’Anno Antonio , Etxebarría Néstor , González-Gaya Belén , Nuzzo Genoveffa , Fontana Angelo , Núñez-Pons Laura 
Published: April 2024

AbstractMarine Porifera host diverse microbial communities, which influence host metabolism and fitness. However, functional relationships between sponge microbiomes and metabolic signatures are poorly understood. We integrate microbiome characterization, metabolomics and microbial predicted functions of four coexisting Mediterranean sponges –Petrosia ficiformis,Chondrosia reniformis,Crambe crambeandChondrilla nucula. Microscopy observations reveal anatomical differences in microbial densities. Microbiomes exhibit strong species-specific trends.C. crambeshares many rare amplicon sequence variants (ASV) with the surrounding seawater. This suggests important inputs of microbial diversity acquired by selective horizontal acquisition. Phylum Cyanobacteria is mainly represented inC. nuculaandC. crambe. According to putative functions, the microbiome ofP. ficiformisandC. reniformisare functionally heterotrophic, whileC. crambeandC. nuculaare autotrophic. The four species display distinct metabolic profiles at single compound level. However, at molecular class level they share a “core metabolome”. Concurrently, we find global microbiome-metabolome association when considering all four sponge species. Within each species still, sets of microbe/metabolites are identified driving multi-omics congruence. Our findings suggest that diverse microbial players and metabolic profiles may promote niche diversification, but also, analogous phenotypic patterns of “symbiont evolutionary convergence” in sponge assemblages where holobionts co-exist in the same area.
A single-cell atlas of lung homeostasis reveals dynamic changes during development and aging
Authors: Jia Hao , Chang Yuan , Chen Yulin , Chen Xiao , Zhang Hang , Hua Xiumeng , Xu Mengda , Sheng Yixuan , Zhang Ningning , Cui Hao , Han Lei , Zhang Jian , Fu Xiaodong , Song Jiangping 
Published: April 2024

AbstractAging is a global challenge, marked in the lungs by function decline and structural disorders, which affects the health of the elderly population. To explore anti-aging strategies, we develop a dynamic atlas covering 45 cell types in human lungs, spanning from embryonic development to aging. We aim to apply the discoveries of lung’s development to address aging-related issues. We observe that both epithelial and immune cells undergo a process of acquisition and loss of essential function as they transition from development to aging. During aging, we identify cellular phenotypic alternations that result in reduced pulmonary compliance and compromised immune homeostasis. Furthermore, we find a distinctive expression pattern of the ferritin light chain (FTL) gene, which increases during development but decreases in various types of lung cells during the aging process.
Predicting which patients with cancer will see a psychiatrist or counsellor from their initial oncology consultation document using natural language processing
Authors: Nunez John-Jose , Leung Bonnie , Ho Cheryl , Ng Raymond T. , Bates Alan T. 
Published: April 2024

Abstract
Background
Patients with cancer often have unmet psychosocial needs. Early detection of who requires referral to a counsellor or psychiatrist may improve their care. This work used natural language processing to predict which patients will see a counsellor or psychiatrist from a patient’s initial oncology consultation document. We believe this is the first use of artificial intelligence to predict psychiatric outcomes from non-psychiatric medical documents.

Methods
This retrospective prognostic study used data from 47,625 patients at BC Cancer. We analyzed initial oncology consultation documents using traditional and neural language models to predict whether patients would see a counsellor or psychiatrist in the 12 months following their initial oncology consultation.

Results
Here, we show our best models achieved a balanced accuracy (receiver-operating-characteristic area-under-curve) of 73.1% (0.824) for predicting seeing a psychiatrist, and 71.0% (0.784) for seeing a counsellor. Different words and phrases are important for predicting each outcome.

Conclusion
These results suggest natural language processing can be used to predict psychosocial needs of patients with cancer from their initial oncology consultation document. Future research could extend this work to predict the psychosocial needs of medical patients in other settings.
The human right to a clean, healthy and sustainable ocean
Authors: Bennett Nathan J. , Morgera Elisa , Boyd David 
Published: April 2024

AbstractThe United Nations General Assembly adopted a resolution in 2022 that formally recognizes that there is a universal human right to a clean, healthy and sustainable environment. Yet there is evidence that human rights impacts associated with the degradation of the ocean environment are accelerating. In this perspective, we highlight how the recognition of the human right to a healthy environment can catalyze ocean action and transform ocean governance. In particular, it can do so through 1) catalyzing marine protection and increasing accountability through clarifying state obligations, 2) improving the inclusiveness of ocean governance, including through prioritizing and empowering groups in situations of vulnerability, and 3) enhancing ocean economy practices through clarifying private sector responsibilities. To those ends, there is an urgent need to move from recognition to implementation in order to protect both current and future generations’ human right to a clean, healthy and sustainable ocean.
Yeast TLDc domain proteins regulate assembly state and subcellular localization of the V-ATPase
Authors: Klössel Samira , Zhu Ying , Amado Lucia , Bisinski Daniel D , Ruta Julia , Liu Fan , González Montoro Ayelén 
Published: April 2024

AbstractYeast vacuoles perform crucial cellular functions as acidic degradative organelles, storage compartments, and signaling hubs. These functions are mediated by important protein complexes, including the vacuolar-type H+-ATPase (V-ATPase), responsible for organelle acidification. To gain a more detailed understanding of vacuole function, we performed cross-linking mass spectrometry on isolated vacuoles, detecting many known as well as novel protein-protein interactions. Among these, we identified the uncharacterized TLDc-domain-containing protein Rtc5 as a novel interactor of the V-ATPase. We further analyzed the influence of Rtc5 and of Oxr1, the only other yeast TLDc-domain-containing protein, on V-ATPase function. We find that both Rtc5 and Oxr1 promote the disassembly of the vacuolar V-ATPase in vivo, counteracting the role of the RAVE complex, a V-ATPase assembly chaperone. Furthermore, Oxr1 is necessary for the retention of a Golgi-specific subunit of the V-ATPase in this compartment. Collectively, our results shed light on the in vivo roles of yeast TLDc-domain proteins as regulators of the V-ATPase, highlighting the multifaceted regulation of this crucial protein complex.
Inference of neutron-star properties with unified crust-core equations of state for parameter estimation
Authors: Davis P. J. , Dinh Thi H. , Fantina A. F. , Gulminelli F. , Oertel M. , Suleiman L. 
Published: April 2024

Context. Relating different global neutron-star (NS) properties, such as tidal deformability and radius, or mass and radius, requires an equation of state (EoS). Determining the NS EoS is therefore not only the science goal of a variety of observational projects, but it also enters in the analysis process; for example, to predict a NS radius from a measured tidal deformability via gravitational waves (GW) during the inspiral of a binary NS merger. To this aim, it is important to estimate the theoretical uncertainties on the EoS, one of which is the possible bias coming from an inconsistent treatment of the low-density region; that is, the use of a so called non-unified NS crust.
Aims. We propose a numerical tool allowing the user to consistently match a nuclear-physics informed crust to an arbitrary high-density EoS describing the core of the star.
Methods. We introduce an inversion procedure of the EoS close to saturation density that allows users to extract nuclear-matter parameters and extend the EoS to lower densities in a consistent way. For the treatment of inhomogeneous matter in the crust, a standard approach based on the compressible liquid-drop (CLD) model approach was used in our work. A Bayesian analysis using a parametric agnostic EoS representation in the high-density region is also presented in order to quantify the uncertainties induced by an inconsistent treatment of the crust.
Results. We show that the use of a fixed, realistic-but-inconsistent model for the crust causes small but avoidable errors in the estimation of global NS properties and leads to an underestimation of the uncertainties in the inference of NS properties.
Conclusions. Our results highlight the importance of employing a consistent EoS in inference schemes. The numerical tool that we developed to reconstruct such a thermodynamically consistent EoS, CUTER, has been tested and validated for use by the astrophysical community.
Endoscopic Endonasal Approach for Residual and Recurrent Craniopharyngioma after Transcranial Approach: A Multi-institutional Experience
Authors: Jani Ronak H. , Raju Sudesh , Kim Miri , Gardner Paul , Zenonos Georgios A. , Snyderman Carl , Wang Eric W. , Patel Chirag , Germanwala Anand V. 
Published: April 2024

Abstract
Objectives While the endoscopic endonasal approach (EEA) has become a well-established surgery for resection of craniopharyngiomas (CP), the utility of this procedure following subtotal resection from open transcranial approach (TCA) surgery has yet to be explored. Here we present a multi-institutional case series of patients who underwent EEA for treatment of recurrent CP originally treated by TCA, demonstrating the viability of this approach as salvage surgery.
Design Retrospective cohort.
Setting Loyola University Medical Center and University of Pittsburgh Medical Center.
Participants Patients who underwent EEA for recurrent CP following an initial TCA between 2003 and 2018.
Main Outcome Measures Gross total resection (GTR) rate, surgical complications, visual outcomes, and endocrine outcomes
Results Patients who underwent EEA for recurrent CP following a prior TCA had a GTR rate of 77%. EEA reoperation was not associated with worsening of visual outcomes as compared with the primary TCA (0% visual worsening after EEA reoperation vs. 40% after primary TCA, p = 0.055). While primary TCA resulted in worsening endocrinopathies in 100% of patients (including seven patients with permanent diabetes insipidus), subsequent EEA for re-resection of CP resulted in stable (30.8%) or improved (69.2%) endocrine function in all patients (p < 0.001).
Conclusions EEA achieves reasonable GTR rates and is an effective, safe surgical option for recurrent CP postinitial TCA. This approach demonstrated stable or improved visual and endocrinologic outcomes in all patients within our two-institution series. Thus, EEA should be considered as an efficacious form of retreatment in cases of progressive and recurrent CP.
Protective Role of MerTK in Diabetic Peripheral Neuropathy via
Inhibition of the NF-κB Signaling Pathway
Authors: Su Xiaoyang , Chen Wenting , Fu Yidan , Wu Bian , Mao Fugang , Zhao Yan , Yang Qiuping , Lan Danfeng 
Published: April 2024

Abstract
Introduction Diabetic peripheral neuropathy (DPN) impacts patient quality
of life. In such patients, increased expression of mer tyrosine kinase (MerTK)
has been demonstrated; however, its mechanism of action remains unclear. In this
study, type 2 diabetes mellitus (T2DM) and DPN models were established in
Sprague Dawley rats via low-dose streptozotocin and a high-fat diet and the mode
of action of MerTK was examined.
Methods MerTK-specific inhibitors were administered by gavage once daily
for 2 weeks. Sciatic nerve conduction velocity and nerve structure were
measured. The levels of MerTK, nuclear factor kappa-light-chain-enhancer of
activated B cells (NF-κB), tumor necrosis factor-alpha (TNF-α), interleukin-1
beta (IL-1β), and relevant biochemical indexes were detected.
Results The study revealed upregulation of MerTK expression in T2DM and
more so in DPN groups. Inhibiting MerTK led to reduced nerve conduction velocity
and further deterioration of sciatic nerve structure, as evidenced by structural
morphology. Concurrently, serum levels of total cholesterol, glycated
hemoglobin, and triglyceride significantly increased. Moreover, levels of NF-κB
increased in both serum and nerve tissue, alongside a significant rise in TNF-α
and IL-1β expressions. MerTK could bind to the inhibitor of kappa B kinase beta
(Ikbkb) in Schwann cells, establishing Ikbkb as a precursor to NF-κB
activation.
Discussion Inhibition of MerTK exacerbates neuropathy, indicating its
protective role in DPN by suppressing the NF-κB pathway, highlighting a
potential new target for its diagnosis and treatment.
High-pressure structures of solid hydrogen: Insights from ab initio molecular dynamics simulations
Authors: Li Cong 
Published: April 2024

Understanding the structural behavior of solid hydrogen under high pressures is crucial for uncovering its unique properties and potential applications. In this study, starting from the phase I of solid hydrogen—free-rotator hcp structure, we conduct extensive ab initio molecular dynamics calculations to simulate the cooling, heating, and equilibrium processes within a pressure range of 80–260 GPa. Without relying on any structure previously predicted, we identify the high-pressure phase structures of solid hydrogen as P21/c for phase II, P6522 for phase III, and BG1BG2BG3 six-layer structure for phase IV, which are different from those proposed previously using the structure-search method. The reasonability of these structures are validated by Raman spectra and x-ray diffraction patterns by comparison with the experimental results. Our results actually show pronounced changes in the c/a ratio between phases I, III, and IV, which hold no brief for the experimental interpretation of an isostructural hcp transformations for phases I–III–IV.
Identification of superior genotypes for leaf architecture traits in Sorghum bicolor through GGE biplot analysis
Authors: Wang Runfeng , Zhao Yingxing , Wang Hailian , Chen Erying , Li Feifei , Huang Shaoming , Qin Ling , Yang Yanbing , Guan Yan’an , Liu Bin , Zhang Huawen 
Published: April 2024

Context Well-organised leaf architecture produces compact canopies and allows for greater sunlight penetration, higher photosynthetic rates, and thus greater yields. Breeding for enhanced leaf architecture of sorghum (Sorghum bicolor L.), a key food source in semi-arid regions, benefits its overall production. Aims The study focuses on selecting useful genotypes with excellent leaf architecture for grain sorghum improvement. Methods In total, 185 sorghum genotypes were subjected to multi-environment trials. Leaf flagging-point length, leaf length, leaf width, leaf angle and leaf orientation value (LOV) were characterised under field conditions. Genotype + genotype × environment interaction (GGE) biplot analysis was used to identify the most stable genotypes with the highest LOV. Key results Statistical analysis showed significant effects of genotype × environment interaction (P < 0.001), and high broad-sense heritability for the traits. Correlation analysis demonstrated negative correlations (P < 0.001) between LOV and its components. Singular value decomposition of LOVs in the first two principal components explained 89.19% of the total variation. GGE biplot analysis identified G55 as the ideotype with the highest and most stable LOV. Conclusions Leaf architecture optimisation should be given greater attention. This study has identified a genotype with optimal and stable leaf architecture, laying the foundation for improvement in breeding to increase overall yields of sorghum. Implications Genotype G55 can be utilised as a parent with other parents that display economically important characteristics in breeding programs to produce offspring that can be planted densely to increase population yields. Genotypes identified with loose leaf architecture are useful in dissecting genes controlling leaf architecture by crossing with G55 to construct genetic mapping populations.
Bordering and crisis narratives to illiberal ends
Authors: Szalai Andras 
Published: April 2024

Abstract
This paper draws lessons from security and populism studies to theorize how radical right-wing populism (RRWP)
utilizes borders as a symbolic resource in crisis narratives to clearly frame an “Us” and a threatening “Them”. By analyzing the
Hungarian Orbán regime’s evolving rhetoric on borders, the paper illustrates how populists employ crisis narratives not to
mitigate, but exacerbate ontological insecurities, and thereby facilitate de-democratization by (re)shaping voter attitudes (cf.
Homolar & Scholz 2019; Steele & Homolar
2019). The paper suggests that populists-in-power rely on crisis and bordering narratives beyond voter mobilization:
such narratives are in fact designed to legitimize and affirm illiberal practices that undermine liberal democracy itself, and
contribute to regime building. Border crises, and crisis politics, hence become a template for the manipulation of individuals’
security-of-being, and thereby a tool in the politics of reassurance and control at the broader, societal level.
From war to crime rhetoric
Authors: D’Ottone Silvana , Varela Micaela , Castro Diego , Carvacho Héctor 
Published: April 2024

Abstract
In October 2019, Chile witnessed an unprecedented social uprising, with millions of citizens rising against social
inequalities and injustice. The government employed various strategies to end demonstrations, including the speeches delivered by
President Piñera. This study aims to explore the representation of protests and their actors in the presidential discourse and how
it evolved over the course of events. Our analysis of themes, discursive actions, and attitudinal appraisals, coupled with a
temporal framework, reveals that the initial framing of the uprising as a war shifted to crime rhetoric, possibly in response to
negative reactions from the audience. Despite the President adopting a seemingly softer rhetoric later on, our study suggests that
violence and division remained prominent themes in his speeches. Examining discourse shifts and fluctuations throughout the
timeline of the social upheaval provides a comprehensive understanding of how political discourse is shaped in the midst of an
unparalleled social uprising
The links between evidentiality, modality, and grammaticalization
Authors: Mélac Eric 
Published: April 2024

Abstract
This paper introduces the main notions that are addressed in this special issue, namely evidentiality, modality,
and grammaticalization. It defines each notion and briefly synthesizes the literature. It also presents some of the controversies
which surround the ideas that prevail in these research fields. Crosslinguistic examples illustrate the main evidential and modal
categories, and clarify why the two domains are both distinct and related. The paper then sketches the main pathways of
grammaticalization of modal and evidential markers as they have been documented in typological work. Finally, it introduces the
contributions to this special issue, highlights the new insights, and discusses what remains to be investigated on the links
between evidentiality, modality, and grammaticalization.
Ibipora lolii (Siviour) Siviour & McLeod
Authors: CABI  , EPPO  
Published: April 2024

Abstract

A new distribution map is provided for Ibipora lolii (Siviour) Siviour & McLeodNematoda: Belonolaimidae Hosts: turfgrasses especially kikuyu grass (
Pennisetum clandestinum
)