bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic heterogeneity of deafness phenotypes linked to DFNA4
Authors: Yang Tao , Pfister Markus , Blin Nikolaus , Zenner Hans P. , Pusch Carsten M. , Smith Richard J.H. 
Published: October 2005

AbstractMutations in the heavy chain of the class II nonmuscle myosin, MYH14, cause autosomal dominant hearing loss in families linked to the DFNA4 locus. Consistent with this discovery, we identified an S120L mutation in MYH14 in a large German family segregating deafness that links to DFNA4. However, complete screening of the American family that originally defined the DFNA4 locus revealed no mutations in this gene. Furthermore, haplotyping of a single nucleotide polymorphism (SNP) 5′ to MYH14 excludes this gene from the critical region in this family. Our results imply that mutations in another gene result in deafness at the DFNA4 locus. The newly defined candidate region encompasses a region of approximately 19 cM. Several candidate genes have been screened for disease‐causing mutations. © 2005 Wiley‐Liss, Inc.
Asplenia in ATR‐X syndrome: A second report
Authors: Leahy Ronan T. , Philip Roy K. , Gibbons Richard J. , Fisher Chris , Suri Mohnish , Reardon William 
Published: October 2005

AbstractMutation at the ATR‐X locus is associated with severe mental retardation. Several conditions, initially reported as clinically distinct phenotypes, have now been attributed to ATR‐X mutation. Asplenia, in association with severe mental retardation, has been reported and subsequently demonstrated in one family to be due to ATR‐X mutation. We now report on a second instance of a patient presenting with mental retardation and asplenia who has been shown to have a mutation at the ATR‐X locus. © 2005 Wiley‐Liss, Inc.
Further delineation of the phenotype maps for partial trisomy 16q24 and Jacobsen syndrome by a subtle familial translocation t(11;16)(q24.2;q24.1)
Authors: Zahn Susanne , Ehrbrecht Antje , Bosse Kristin , Kalscheuer Vera , Propping Peter , Schwanitz Gesa , Albrecht Beate , Engels Hartmut 
Published: October 2005

AbstractWe report on two cases of distal monosomy 11q and partial trisomy 16q due to a familial subtle translocation detected by FISH subtelomere screening. Exact breakpoint analyses by FISH with panels of BAC probes demonstrated a 9.3–9.5 megabase partial monosomy of 11q24.2‐qter and a 4.9–5.4 megabase partial trisomy of 16q24.1‐qter. The index patient displayed craniofacial dysmorphisms, mild mental retardation and postnatal growth retardation, muscular hypotonia, mild periventricular leukodystrophy, patent ductus arteriosus, thrombocytopenia, recurrent infections, inguinal hernia, cryptorchidism, pes equinovarus, and hearing deficiencies. In his mother's cousin who bears the identical unbalanced translocation, mild mental retardation, patent ductus arteriosus, hypogammaglobulinemia, recurrent infections, unilateral kidney hypoplasia, pes equinovarus, and hearing deficiencies were reported. Since only four descriptions of cryptic or subtle partial trisomies 16q have been published to date, our patients contribute greatly to the delineation of the phenotype of this genomic imbalance. In contrast to this, terminal deletions of the long arm of chromosome 11 cause a haploinsufficiency disorder (Jacobsen syndrome) in which karyotype–phenotype correlations are already being established. Here, our findings contribute to the refinement of a phenotype map for several Jacobsen syndrome features including abnormal brain imaging, renal malformations, thrombocytopenia/pancytopenia, inguinal hernia, testicular ectopy, pes equinovarus, and hearing deficiency. © 2005 Wiley‐Liss, Inc.
Organotin contamination, imposex and androgen/oestrogen ratios in natural populations of Nassarius reticulatus along a ship density gradient
Authors: Barroso C. M. , Reis‐Henriques M. A. , Ferreira M. , Gibbs P. E. , Moreira M. H. 
Published: October 2005

AbstractLevels of organotin body burden (expressed as tin), imposex and steroid hormones (testosterone, 17β‐oestradiol, testosterone glucuronide and sulfate conjugates) were investigated in natural populations of Nassarius reticulatus in the Ria de Aveiro (northwest Portugal) between 1997 and 1999. The tributyltin (TBT) whole body burden (b.b.) of females presented increasing gradients from the adjacent open coast (16–26 ng g−1 dry weight (d.w.)) towards the ports inside the Ria de Aveiro (195–272 ng g−1 d.w.). Triphenyltin b.b. was only detected at the most polluted port (22 ng g−1 d.w.). Imposex also presented increasing values from the adjacent coast (vas deferens sequence index (VDSI): 0.0–0.5; relative penis length index (RPLI): 0.0–2.4; penis length index (PLI): 0.0–0.3 mm; percentage of affected females (%I): 0–30) towards the ports (VDSI: 3.8–4.8; RPLI: 51–80; PLI: 6.7–10.8 mm; %I: 100). The testosterone levels in females without imposex were always lower than in females with imposex, and the ratio of testosterone/17β‐oestradiol in females tended to increase with increasing imposex and organotin contamination. In spite of the large difference in the female testosterone and 17β‐oestradiol levels between summer and winter, related to the reproductive cycle, the spatial trend of the testosterone/17β‐oestradiol ratio was remarkably similar in shape and values in the two seasons. Imposex was significantly correlated with the TBT b.b. and the testosterone/17β‐oestradiol ratio in females. The testosterone conjugate levels did not show any clear pattern with the increasing values of imposex and TBT contamination. Copyright © 2005 John Wiley & Sons, Ltd.
Electrocatalytic oxidation of sulfite by acetylferrocene at glassy carbon electrode
Authors: Gao Zuo‐Ning , Ma Jin‐Fu , Liu Wan‐Yi 
Published: October 2005

AbstractThe electrochemical oxidation of sulfite catalyzed by acetylferrocene (AFc) at a glassy carbon electrode (GCE) in 0.2 M NaClO4 aqueous solution has been studied by cyclic voltammetry. Although sulfite itself showed a sluggish electrochemical response at the GCE, the response could be enhanced greatly by using AFc as a mediator, which enables a sensitive determination of the substrate (sulfite). The reaction rate constant for catalytic oxidation was evaluated as (7.02 ± 0.05) × 104 M−1 s−1 by chronoamperometry. Experimental conditions that maximize the current efficiency of the electrocatalytic oxidation, such as the pH and both the catalyst (AFc) and substrate (sulfite) concentrations, were also investigated. The electrochemical kinetics of electrocatalytic oxidation of sulfite by AFc has been studied by cyclic voltammetry. In the presence of 5 × 10−4 M AFc, the oxidation current is proportional to the sulfite concentration and the calibration plot was linear over the concentration range 2 × 10−4–2.4 × 10−3 M. This result can be applied in the determination of real samples. Copyright © 2005 John Wiley & Sons, Ltd.
On the reactivity of platina‐β‐diketones: a straightforward synthesis of trans‐acetylchlorobis(phosphine)platinum(II) complexes and their reactivity
Authors: Albrecht Christian , Wagner Christoph , Merzweiler Kurt , Lis Tadeusz , Steinborn Dirk 
Published: October 2005

AbstractThe platina‐β‐diketone [Pt2{(COMe)2H}2(µ‐Cl)2] (1) was found to react with monodentate phosphines to yield acetyl(chloro)platinum(II) complexes trans‐[Pt(COMe)Cl(PR3)2] (PR3 = PPh3, 2a; P(4‐FC6H4)3, 2b; PMePh2, 2c; PMe2Ph, 2d; P(n‐Bu)3, 2e; P(o‐tol)3, 2f; P(m‐tol)3, 2g; P(p‐tol)3, 2h). In the reaction with P(o‐tol)3 the methyl(carbonyl)platinum(II) complex [Pt(Me)Cl(CO){P(o‐tol)3}] (3a) was found to be an intermediate. On the other hand, treating 1 with P(C6F5)3 led to the formation of [Pt(Me)Cl(CO){P(C6F5)3}] (3b), even in excess of the phosphine. Phosphine ligands with a lower donor capability in complexes 2 and the arsine ligand in trans‐[Pt(COMe)Cl(AsPh3)2] (2i) proved to be subject to substitution by stronger donating phosphine ligands, thus forming complexes trans‐[Pt(COMe)Cl(L)L′] (L/L′ = AsPh3/PPh3, 4a; PPh3/P(n‐Bu)3, 4b) and cis‐[Pt(COMe)Cl(dppe)] (4c). Furthermore, in boiling benzene, complexes 2a–2c and 2i underwent decarbonylation yielding quantitatively methyl(chloro)platinum(II) complexes trans‐[Pt(Me)Cl(L)2] (L = PPh3, 5a; P(4‐FC6H4)3, 5b; PMePh2, 5c; AsPh3, 5d). The identities of all complexes were confirmed by 1H, 13C and 31P NMR spectroscopy. Single‐crystal X‐ray diffraction analyses of 2a·2CHCl3, 2f and 5b showed that the platinum atom is square‐planar coordinated by two phosphine ligands (PPh3, 2a; P(o‐tol)3, 2f; P(4F‐C6H4)3, 5b) in mutual trans position as well as by an acetyl ligand (2a, 2f) and a methyl ligand (5b), respectively, trans to a chloro ligand. Single‐crystal X‐ray diffraction analysis of 3b exhibited a square‐planar platinum complex with the two π‐acceptor ligands CO and P(C6F5)3 in mutual cis position (configuration index: SP‐4‐3). Copyright © 2005 John Wiley & Sons, Ltd.
Influence of metal core of mixed‐metal carboxylates in preparation of spinel: ZnFe2O(O2CCF3)6 as a single‐source precursor for preparation of ZnFe2O4
Authors: Amini M. M. , Yadavi M. 
Published: October 2005

AbstractThe mixed‐metal and mixed‐valance carboxylates of MFe2O(O2CCF3)6(C4H8O)2(H2O) (M = Zn, Mn, Cu) and MFe2O(O2CCCl3)6(C4H8O)2(H2O) (M = Zn, Fe) were utilized as potential precursors for the preparation of spinel. In the pyrolysis of ZnFe2O(O2CCF3)6(C4H8O)2(H2O) in air at 400 °C pure ZnFe2O4 is formed, in contrast to pyrolysis of the trichloro derivative, which resulted in the formation of ZnO and Fe2O3. In the pyrolysis of MnFe2O(O2CCF3)6(C4H8O)2(H2O) in nitrogen, MnFe2O4 was the main phase and single oxides were the minor phases. Copyright © 2005 John Wiley & Sons, Ltd.
On the Importance of Carbohydrate–Aromatic Interactions for the Molecular Recognition of Oligosaccharides by Proteins: NMR Studies of the Structure and Binding Affinity of AcAMP2‐like Peptides with Non‐Natural Naphthyl and Fluoroaromatic Residues
Authors: Chávez M. Isabel , Andreu Cecilia , Vidal Paloma , Aboitiz Nuria , Freire Felix , Groves Patrick , Asensio Juan Luis , Asensio Gregorio , Muraki Michiro , Cañada Francisco Javier , Jiménez‐Barbero Jesús 
Published: October 2005

AbstractThe specific interaction of a variety of modified hevein domains to chitooligosaccharides has been studied by NMR spectroscopy in order to assess the importance of aromatic–carbohydrate interactions for the molecular recognition of neutral sugars. These mutant AcAMP2‐like peptides, which have 4‐fluoro‐phenylalanine, tryptophan, or 2‐naphthylalanine at the key interacting positions, have been prepared by solid‐phase synthesis. Their three‐dimensional structures, when bound to the chitin‐derived trisaccharide, have been deduced by NMR spectroscopy. By using DYANA and restrained molecular dynamics simulations with the AMBER 5.0 force field, the three‐dimensional structures of the protein–sugar complexes have been obtained. The thermodynamic analysis of the interactions that occur upon complex formation have also been carried out. Regarding binding affinity, the obtained data have permitted the deduction that the larger the aromatic group, the higher the association constant and the binding enthalpy. In all cases, entropy opposes binding. In contrast, deactivation of the aromatic rings by attaching fluorine atoms decreases the binding affinity, with a concomitant decrease in enthalpy. The role of the chemical nature of the aromatic ring for establishing sugar contacts has been thus evaluated.
Electron‐Rich Diferrous–Phosphane–Thiolates Relevant to Fe‐only Hydrogenase: Is Cyanide “Nature's Trimethylphosphane”?
Authors: van der Vlugt Jarl Ivar , Rauchfuss Thomas B. , Wilson Scott R. 
Published: October 2005

AbstractThe two‐step one‐pot oxidative decarbonylation of [Fe2(S2C2H4)(CO)4(PMe3)2] (1) with [FeCp2]PF6, followed by addition of phosphane ligands, led to a series of diferrous dithiolato carbonyls 2–6, containing three or four phosphane ligands. In situ measurements indicate efficient formation of 12+ as the initial intermediate of the oxidation of 1, even when a deficiency of the oxidant was employed. Subsequent addition of PR3 gave rise to [Fe2(S2C2H4)(μ‐CO)(CO)3(PMe3)3]2+ (2) and [Fe2(S2C2H4)(μ‐CO)(CO)2(PMe3)2(PR3)2]2+ (R=Me 3, OMe 4) as principal products. One terminal CO ligand in these complexes was readily substituted by MeCN, and [Fe2(S2C2H4)(μ‐CO)(CO)2(PMe3)3(MeCN)]2+ (5) and [Fe2(S2C2H4)(μ‐CO)(CO)(PMe3)4(MeCN)]2+ (6) were fully characterized. Relevant to the Hred state of the active site of Fe‐only hydrogenases, the unsymmetrical derivatives 5 and 6 feature a semibridging CO ligand trans to a labile coordination site.
Mechanistic Investigation of the 2,5‐Diphenylpyrrolidine‐Catalyzed Enantioselective α‐Chlorination of Aldehydes
Authors: Halland Nis , Alstrup Lie Mette , Kjærsgaard Anne , Marigo Mauro , Schiøtt Birgit , Jørgensen Karl Anker 
Published: October 2005

AbstractThe mechanism for the 2,5‐diphenylpyrrolidine‐catalyzed enantioselective α‐chlorination of aldehydes with electrophilic halogenation reagents has been investigated by using experimental and computational methods. These studies have led us to propose a mechanism for the reaction that proceeds through an initial N‐chlorination of the chiral catalyst–substrate complex, followed by a 1,3‐sigmatropic shift of the chlorine atom to the enamine carbon atom. The suggested reaction course is different from previously proposed mechanisms for organocatalytic enamine reactions, in which the carbon–electrophile bond is formed directly. Furthermore, the rate‐determining step in the overall reaction was determined and the presence of nonlinear effects was probed.
Metal Aminocarboxylate Coordination Polymers with Chain and Layered Structures
Authors: Dan Meenakshi , Rao C. N. R. 
Published: October 2005

AbstractThe synthesis and structures of metal aminocarboxylates prepared in acidic, neutral, or alkaline media have been explored with the purpose of isolating coordination polymers with linear chain and two‐dimensional layered structures. Metal glycinates of the formulae [CoCl2(H2O)2(CO2CH2NH3)] (I), [MnCl2(CO2CH2NH3)2] (II), and [Cd3Cl6(CO2CH2NH3)4] (III) with one‐dimensional chain structures have been obtained by the reaction of the metal salts with glycine in an acidic medium under hydro/solvothermal conditions. These chain compounds contain glycine in the zwitterionic form. 4‐Aminobutyric acid transforms to a cyclic amide under such reaction conditions, and the amide forms a chain compound of the formula [CdBr2(C4H7NO)2] (IV). Glycine in the zwitterionic form also forms a two‐dimensional layered compound of the formula [Mn(H2O)2(CO2CH2NH3)2]Br2 (V). 6‐Aminocaproic acid under alkaline conditions forms layered compounds with metals at room temperature, the metal being coordinated both by the amino nitrogen and the carboxyl oxygen atoms. Of the two layered compounds [Cd{CO2(CH2)5NH2}2]⋅2 H2O (VI) and [Cu{CO2(CH2)5NH2}2]⋅2 H2O (VII), the latter has voids in which water molecules reside.
Assembly of Au Nanoparticles with Anisotropic Optical Property Directed by 2′‐Phosphorothioate Oligo‐DNA
Authors: Yang Bai‐Quan , Jiang Lin , Zhuang Jia‐Qi , Liu Yi‐Chun , Xu Wu , Li Tie‐Jin 
Published: October 2005

AbstractTwo complemental 2′‐phosphorothioate oligo‐DNA compounds were used as linker molecules to provide the necessary symmetry‐breaking mechanism to direct the assembly of 13 nm Au nanoparticles into aggregates with anisotropic optical properties.
Study on Thermochemistry and Thermal Decomposition Kinetics of Dy(Tyr)(Gly)3Cl3·3H 2O
Authors: Zhang Zhong‐Hai , Ku Zong‐Jun , Liu Yi , Qu Song‐Sheng 
Published: October 2005

Abstract The complex of dysprosium chloride with glycine and L‐tyrosine, Dy(Tyr)(Gly)3Cl3· 3H2O, was synthesized and characterized. The standard molar formation enthalpy of Dy(Tyr)(Gly)3Cl3· 3H2O at T=298.15 K was determined to be (‐4287.10±2.14) kJ/mol. The kinetics of thermal decomposition of the complex was studied by non‐isothermal TG‐DTG curves. The kinetic parameters and mechanism function of the thermal decomposition reaction for its second step were proposed. The kinetic equation could be expressed as: dα/dT=3.14×1020s‐1/βexp(‐209.37 kJ·mol‐1/RT)(1−α) 2.
Preparation and Electrochemical Properties of Manganese Hexacyanoferrate Modified Glassy Carbon Electrode
Authors: Liu You‐Qin , Yan Yun , Shen Han‐Xi 
Published: October 2005

Abstract A thin film of manganese hexacyanoferrate (MnHCF) was electrochemically formed on a glassy carbon (GC) electrode to prepare a chemically modified electrode (CME). The mechanism of film formation of MnHCF and its growth process were investigated in detail by cyclic voltammetry. The results show that the stoichiometric composition of MnHCF is MnIIIFeIII(CN)6, an analogue of prussian yellow. There exist three clear‐cut stages in the whole modification process and the last stage is indispensable to the fabrication of homogenized, stable MnHCF film and must last for an appropriate time. The surface morphology of MnHCF/GC electrode was characterized by scanning electron microscopy (SEM), which further verified the effective deposition of MnHCF film on GC. The kinetic constants of MnHCF/GC electrode process were also evaluated. The resulting MnHCF film modified electrode presented good stability and high electrocatalytic activity toward the oxidation of H2O2, indicating that MnHCF film possesses function of catalase and can be expected for analytical purposes.
Applications of Simple Estimation Scheme of Electron Correlation Energy to Strong Ionic Compounds
Authors: Zhuo Shu‐Ping , Wei Ji‐Chong , Ju Guan‐Zhi 
Published: October 2005

AbstractThe calculation results of electron correlation energies of KF and (KF)2 were reported. The transferability of lsK2, lsF2 and the inner core correlation effects of K and F in both K, K+, KF and F, F‐, KF systems were investigated respectively. The correlation energy contributions of K and F component to KF system were calculated. By applying the simple estimation scheme to the calculation of the correlation energy of the strong ionic compound KF and (KF) 2, it was shown that such a powerful scheme could not only reach the chemical accuracy but also need little computational work.
Study on Modification and Test Technology of Nonexplosive and Irrestorable Fertilizer‐grade Ammonium Nitrate
Authors: Shen Li‐Jin , Wang Xu‐Guang 
Published: October 2005

Abstract Based on a study of the relationship of ammonium nitrate (AN) explosion and its thermal stability, inert agents were added to AN for eliminating the explosive characteristic of AN and in order to be irrestorable. The results of using a large quantity of experiments and various testing technologies show that the improvement on thermal stability of modified AN is the basic reason for eliminating explosive characteristic of AN. The modification scheme was considered to have the following features: reliable and stable technology, market‐demanded product, low investment and good economic returns. And during the revamping period, the normal production of AN will not be affected, and the economic, social and environmental benefits are good.
AIM Study on Reaction HNCX → HXCN (X=O, S and Se)
Authors: Zeng Yan‐Li , Meng Ling‐Peng , Zheng Shi‐Jun 
Published: October 2005

Abstract The reactions of HNCO to HOCN, HNCS to HSCN and HNCSe to HSeCN have been studied at MP2/6‐311+ +G(2df,pd)//B3LYP/6‐311+ +G(2df,pd) level. Geometries of the reactants, transition states and products have been optimized and geometries of the transition states are reported for the first time. The reasons why HNCO and HNCS instead of HOCN and HSCN were easily detected have been explained. It was predicted that HNCSe will be more easily detected than HSeCN. The breakage and formation of the chemical bonds in the reactions have been discussed by the topological analysis method of electronic density. The calculated results show that there are two kinds of structure transition states (STS) in reactions studied.
Crystal Structure and Bioactivity of Complex [Gd(C10H9N2O4)(C10H8N2O4)(H2O) 3]2·phen·4H2O
Authors: He Shui‐Yang , Yang Rui , Wu Wang‐Ting , Shi Qi‐Zhen , Wang Da‐Qi , An De‐Rong 
Published: October 2005

AbstractA novel gadolinium(III) complex with N‐(2‐propionic acid)‐salicyloyl hydrazone (C10H10N2O4, H3L) and 1,10‐phenanthroline (C12H8N2, phen) was prepared and characterized. The crystal structure of [Gd(H2L)(HL)‐(H2O)3]2·phen·4H2O was determined by X‐ray single crystal diffractometry. The crystal complex crystallizes in the triclinic system with space group P‐1. There are two 9‐coordinated structure units in every complex molecule, in which Gd(III) is coordinated by two tridentate ligands (H2L and HL forms) and three water molecules and both the structural units take a distorted monocapped square antiprism. There is a free 1,10‐phenanthroline connecting with coordinated water by hydrogen bonds in the crystal. The bioactivity tests indicate that the complex is an inhibitor against three bacteria.
Studies of Iron‐Sulfur Covalency in the Model System and Proteins
Authors: Qin Xiu‐Juan , Chen Yan , Gao Fa‐Ming 
Published: October 2005

AbstractIt was found that the highly covalent nature of the metal‐ligand interactions in the Fe‐S cluster clearly played an important role in determining the reactivity of the sites. A semi‐empirical model, based on the Phillips theory of bonding was developed for quantitative explanation of covalency in Fe‐S cluster, showing that Mossbauer spectroscopy and electronic absorption spectroscopy provided the direct experimental probe of covalency of Fe‐S4 clusters.
Reduction of Nitrogen on Gallium Phosphide Nanoparticles
Authors: Zhang Zhao‐Chun , Cui De‐Liang 
Published: October 2005

Abstract Under mild ambient conditions gallium phosphide (GaP) nanoparticles were employed to carry out the reduction of nitrogen. By using Nessler's reagent ammonia was detected in the slurry where the aggregated GaP particles were suspended in water and bubbled by pure nitrogen. Dependence of the concentration of ammonia upon bubbling time, velocity of the flow of nitrogen, and dosage of GaP particles was investigated. In comparison with the original GaP nanoparticles, the Raman scattering of the GaP particles undergoing the process of nitrogen fixation reveals that two sharp lines at 138 and 182 cm‐1, respectively, emerged from the broad continuum around 100–200 cm‐1. These two lines might be assigned to the translational motions of ammonia adsorbed on the surface of the GaP particles. An assessment of the infrared spectra of the two GaP particles led to the conclusion that the environment of the two H2O molecules was not identical. Analysis of the electron spin resonance results showed that the structure defect, gallium self‐interstitial, was not involved in the nitrogen fixation of the GaP nanoparticles.
One‐pot Synthesis ofN‐Hydroxylacridine Derivatives in Water
Authors: Shi Da‐Qing , Mou Jie , Zhuang Qi‐Ya , Wang Xiang‐Shan 
Published: October 2005

AbstractN‐Hydroxylacridinedione derivatives were synthesized by three‐component reaction of aromatic aldehydes, 1,3‐dicarbonyl compounds and hydroxylamine hydrochloride using triethylbenzylammonium chloride (TEBA) as the catalysis in water. The reaction has many advantages including good yields, easy to be separated and environmental friendliness.
Asymmetric Synthesis of 5‐Hexadecanolide
Authors: Sun Bin , Zhang Chao‐Xin , Zhang Gui‐Min , Li Ying , Li Yu‐Lin , Peng Li‐Zeng 
Published: October 2005

AbstractOptically pure S‐5‐hexadecanolide (1) has been easily prepared from readily available aldehyde 2 and cyclopentanone (3) using L‐proline‐catalyzed asymmetric aldol reactions as the key step.