bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Bitter Melon's Extract Fraction (Momordica Charantia L.) on Blood Sugar Reduction, Insulin Resistance and Phosphatidyl Inositol 3-Kinase (PI3K) Signalling in Male Rats (Rattus novergicus) Streptozotocin-Induced Hyperglycemia
Authors: Nadya Damanik Gustiany 
Published: April 2024

Background: Diabetes mellitus (DM) is a metabolic disease characterized by symptoms of hyperglycemia as a result of impaired insulin secretion. The main cause of type 2 diabetes mellitus is metabolic disorders characterized by insulin receptor resistance, reduced ability of β-pancreatic cells to secrete insulin, and abnormalities in insulin secretion from pancreatic β islet of Langerhans cells. In insulin resistance, the presence of impaired signaling in Phosphatidylinositol 3-kinase (PI3K) disrupts glucose regulation in the body. The purpose of this study was to determine the effect of bitter melon extract (Momordica charantia L.) on blood sugar reduction, insulin resistance and phosphatidyl inositol 3-kinase (PI3K) signaling.
Purpose : The objectives of this study are Effect of Bitter Melon's Extract Fraction (Momordica Charantia L.) on Blood Sugar Reduction, Insulin Resistance and Phosphatidyl Inositol 3-Kinase (PI3K) Signalling in Male Rats (Rattus novergicus) Streptozotocin-Induced Hyperglycemia
Method: This study used a type of laboratory experimental research post-test randomized controlled group design on hyperglycemic male rats (Rattus novergicus). All data analysis is done using SPSS software.
Results: Based on research conducted, it is known that bitter melon extract affects blood sugar, insulin resistance and PI3K signaling.
Conclusion: Bitter melon extract has potential as an herbal antidiabetic remedy
KUALITAS LABA PADA SEKTOR INFRASTRUKTUR KONTRUKSI BANGUNAN DAN JASA TELEKOMUNIKASI NIRKABEL DITINJAU DARI STRUKTUR MODAL DAN UKURAN PERUSAHAAN
Authors: Faisal Yusuf , Putri Meiliana Nadya 
Published: April 2024

Purpose: This study aims to determine the effect of Capital Structure and Company Size on Earnings Quality
Design/methodology/approach: This research uses quantitative data, the sample in this research is infrastructure sector companies in the building construction and wireless telecommunications services sub-sectors listed on the Indonesia Stock Exchange in the 2018 – 2022 period, totaling 13 companies. The analysis technique used to test the hypothesis is multiple regression analysis using Eviews 9 software.
Findings: The results of this study indicate that the Capital Structure variable has a positive and statistically insignificant effect on Earnings Quality, the Company Size variable has a positive and statistically insignificant effect on Earnings Quality.
Originality/value: This research discusses Profit Quality and other factors such as Capital Structure and Company Size which focuses on infrastructure sector companies in the building construction and wireless telecommunications services sub-sectors.
Perkembangan Pendidikan di Indonesia
Authors: Zamhari Zamhari  , Dwi Noviani  , Zainuddin Zainuddin  
Published: April 2024

Education is a key element in the development of society and the country. This article examines the development of education in Indonesia with a focus on the background, results and conclusions of the historical journey of education in this country. The development of education in Indonesia has been influenced by a long history, especially the period of Dutch colonialism. Education at that time was limited to the native elite and created inequality in access to education. However, after the proclamation of independence in 1945, education became a top priority in national development, resulting in a significant increase in access to basic education. Nevertheless, educational inequality between urban and rural areas and between islands in Indonesia remains a problem that must be addressed..Educational developments in Indonesia include increasing access to education, diversifying higher education programs, and efforts to integrate local culture in the curriculum. The government has allocated a significant budget for education, modernizing the curriculum and improving the quality of teaching. Education reform also includes teacher training and curriculum updates to face changing times. However, there are still challenges in educational governance, unequal access to education, and integrating technology in the learning process. The development of education in Indonesia reflects a journey full of challenges and significant changes. While there has been progress in terms of access and cultural integration efforts, challenges such as educational inequality, complex governance, and technology integration still need to be addressed. Quality education remains a priority, with the hope that continued efforts will ensure that education in Indonesia meets high quality standards and is relevant to face a challenging future.
Keywords: Education, Indonesia, History
Fenomena Perilaku Psikopat Dalam Novel Heartbeat Karya Jealoucy: Kajian Psikologi Sastra
Authors: Nurizkia Nabila  , Yurza Aina Zia Ulhaq  , Eva Dwi Kurniawan  
Published: April 2024

In recent years, there has been an alarming increase in crime cases in Indonesia, sometimes linked to psychiatric symptoms. Psychosis is a form of mental disorder characterized by a lack of personal organization and integration, an inability to take moral responsibility, and frequent conflicts with social norms and laws due to illness.mental, created by your own imagination.This study aims to describe the phenomenon of psychopathic behavior in Jealoucy's novel Heartbeat using a literary psychology approach, specifically using Sigmund Freud's theory of psychopathic personality disorder.Basically, literary psychology deals with the psychology of fictional characters in literary works. The data analysis technique used is a qualitative descriptive technique. Based on the results of several studies, it can be seen that (1) the psychopathic behavior of the characters in Jealoucy's novel Heartbeat is known to be based on specific behavioral characteristics of psychopaths, specifically, their penchant for manipulation and action. aggressive, brutal behavior, without remorse or guilt, capable of recognizing forms of psychopathic behavior divided into 3 types: mild, moderate and severe. (2) The factors that cause the characters in the novel Heartbeat to have psychopathic behaviorare genetic factors and environmental factors.
Peningkatan Keterampilan Menulis Puisi Melalui Metode ARCS Dengan Menggunakan Media Gambar
Authors: Ririn Sabriadi  
Published: April 2024

The purpose of this study is to describe the poetry writing ability of grade VIII MTs students of Sorong City. The low ability to write poetry is caused by learning to write poetry that has not been carried out properly so that grade VIII students have difficulty when asked to write poetry.Therefore, the necessary learning strategies and instructional media fun and appropriate. To overcome these problems ARCS Metode and media images of events contained in the newspaper in teaching poetry writing class VIII MTs Sorong Affairs. The research was conducted in two cycles. Each cycle consists of planning, action, observation and reflection. The results of this study indicate the existence of a process of learning, improvement, and change behavior in a positive direction.
Fungsi Gordang Sambilan dalam Masyarakat Kampung Tongah Kecamatan Rao Kabupaten Pasaman Timur
Authors: Fadhila Yoelian  , Syeilendra Syeilendra  
Published: April 2024

This study aims to find the function of Gordang sambilan in the wedding ceremony of the people of Tongah Village, Rao District, East Pasaman Regency. This type of research is qualitative research using a descriptive approach. This research instrument is the researcher himself and is assisted by supporting instruments such as stationery, cameras and cellphones. The data in this study used primary data and secondary data. Data collection techniques are carried out by means of literature studies, observations, interviews and documentation. The steps of analyzing data are collecting data, describing data and inferring data. The results showed that in Tongah Village, Rao District, Pasaman Regency, there is a form of traditional art that has developed until now which is named after its supporting community as Gordang Sambilan music. The people of Tongah Village use Gordang Sambilan music for horja Godang traditional ceremonies as a function of emotional expression, entertainment function, communication function, physical reaction function, aesthetic pleasure function, symbolic representation function. Gordang sambilan music in Tongah Village can be enjoyed and used by all groups both in terms of age and in terms of social status.
EXPERIMENTAÇÕES DE PRECEPTORES EM FORMAÇÃO POR UM CURSO DE ESPECIALIZAÇÃO EM PRECEPTORIA MULTIPROFISSIONAL NA ÁREA DA SAÚDE
Authors: Félix do Nascimento Fransuélio , Xavier Guedes Ieda , De Carvalho Gomes Juliana , Ferreira Monteiro E Oliveira Luciana , Brito Macedo Marriane , Nascimento da Silva Rafael , Dias Thuany Rodrigues , Fernando Frederico Deison 
Published: April 2024

Objetivo:descrever a experiência do processo de formação de preceptores em curso de especialização multiprofissional com foco na interprofissionalidade e práticas colaborativas. Métodologia: relato de experiência utilizando se o Arco de Maguerez, de profissionais no Curso de Especialização em Preceptoria Multiprofissional na Área da Saúde, em especial do módulo de Gestão de Programa de Residência na Área da Saúde e a Organização do Serviço para o Ensino, mais especificamente o Processo de Ensino e Aprendizagem: Foco em Interdisciplinaridade e trabalho em Equipe. Relato de Experiência: O relato demonstra que a construção pedagógica se deu em três módulos trazendo subsídios necessários à mudança de nossa prática, oportunizando conhecimentos pedagógicos em um ensino baseado em uma pedagogia crítica e problematizadora, como também aprofundarmos reflexões sobre as mesmas e possibilidade de exercer a preceptoria de modo crítico, reflexivo e contextualizado. Conclusão: A experiência realizada demonstra que a formação de preceptores em um Curso de Especialização Multiprofissional na Área da Saúde, utilizando de tecnologias de Ensino à Distância, encontros remotos e metodologias ativas, nos permitiu uma jornada transformadora. A ênfase na interdisciplinaridade e práticas colaborativas preparadas para enfrentar os desafios da preceptoria de forma mais eficaz, promovendo uma formação de qualidade e, consequentemente, uma assistência à saúde mais integrada e centrada no paciente.
dos caras de la Inteligencia Artificial
Authors: Puyén Fernández Elizabeth 
Published: April 2024

La Inteligencia Artificial (IA) a lo largo del tiempo ha sido representada en el mundo del cine como un acto terrorífico, pues justamente ahí radica el miedo de las personas donde las máquinas con IA implementan la nueva orden utilizando a los humanos como sus esclavos; si bien es cierto nosotros no podemos determinar el futuro, sin embargo, lo que sí es una realidad es que la Inteligencia artificial ya forma parte de nuestra vida diaria. Es por ello por lo que, el objetivo principal de este trabajo es poder reconocer cuál es el impacto que acarrea el uso de la inteligencia artificial. Para ello se ha desarrollado una investigación profunda sobre diversos autores y libros relevantes en cuanto a la Inteligencia artificial, siendo que la muestra recae en la población que utiliza la Inteligencia artificial, así como las empresas que la crean. Obteniendo como resultado que la IA no solamente posee un lado beneficioso, sino también puede llegar a ser perjudicial para muchos si no existe una buena concientización sobre su uso. En conclusión, el uso y creación desproporcionado e inconsciente de la IA, puede conllevar a una dependencia y vulneración de derechos de muchos usuarios, por lo que el gobierno debe intervenir para que ello no suceda.
Persepsi Taruna Terhadap Pembelajaran Menggunakan E-Learning
Authors: Sulistiana Oktavera , Syam Nur , Saleh Muhammad 
Published: April 2024

The pupose of this study determine the perceptions of cadets towards online distance learning methods. This study used descriptive qualitative method. Perception assessment is carried out by referring to 3 components, namely: components of understanding On Line learning, constraints in taking On Line learning, Suggestions for the Quality of Online learning. Data collection was carried out using an online questionnaire through Google Form to 92 diploma III cadets who were participating in distance learning using purposive random sampling technique. The results showed that the results of several components of distance learning that were given to the respondents, on average, supported and rated positively towards online distance learning methods carried out by cadets
Characterization Of First Metatarsal Regeneration After New Modern Minimally Invasive Bunion Surgery. A Retrospective Radiographic Review Of 172 Cases.
Authors: Blitz Neal M , Wong David T , Grecea Bogdan , Baskin Eric 
Published: April 2024

Introduction First metatarsal regeneration (FMR) is a new phenomenon that occurs as a result of new minimally invasive bunion surgery (MIBS) and has yet to be studied. The goal of this investigation is to characterize bone healing and introduce a new classification system (3 Types). Methods A retrospective radiographic review between January 2018 to June 2021 was performed, identifying 172 feet (122 patients). A minimum of four months of follow-up was required to be included. We classified the extent of callus formation based on the relationship to the primary “anchor” screw. A FMR Type I involved callus medial to the screw, FMR Type II involved callus medial and lateral to the screw, and FMR Type III had robust callus with first metatarsal regeneration. Results Mean age was 46.6±14.6 years; 117 (95.9%) females and 5 (4.1%) males. Mean follow-up was 8.2±5.7 months. The FMR bone healing distributions were Type I (17.4%, 30 feet), Type II (42.4%, 73 feet), and Type III (40.1%, 69 feet). There was a statistically significant overall difference in both IM and HVA, (P<0.001), which was maintained across all FMR types (I-III, p<0.0001 for all comparisons). No statistical significant correlation between FMR type and age, sex, laterality, operation on both or one foot, length of follow-up, and pre- and postop radiographic angles. The same FMR type occurred in bilateral surgery in 28% when performed on the same day, and 20% on different days; and these differences were not statistically significant. Conclusion This is the first investigation to provide patterns of healing after MIBS, and evidence that FMR does occur for all bunion severities. Surgeons considering performing MIBS should no longer fear that bone healing is not possible. Our classification will help guide future studies by comparing the FMR with different techniques, fixation types/constructs and/or weight bearing protocols.
Nanoporous Plasmonic Metamaterials
Authors: Biener Juergen , Nyce Gregory W. , Hodge Andrea M. , Biener Monika M. , Hamza Alex V. , Maier Stefan A. 
Published: March 2008

AbstractWe review different routes for the generation of nanoporous metallic foams and films exhibiting well‐defined pore size and short‐range order. Dealloying and templating allows the generation of both 2D and 3D structures that promise a plasmonic response determined by material constituents and porosity. Viewed in the context of metamaterials, the ease of fabrication of samples covering macroscopic dimensions is highly promising, and suggests more in‐depth investigations of the plasmonic and photonic properties of this material system for photonic applications.
A simulated genetic structure for bipolar illness
Authors: Nurnberger John I. 
Published: March 2008

AbstractBipolar illness is conceptualized as a polygenic condition. Based on candidate gene findings from the literature to date, up to 22% of the genetic risk in affected persons may be explained by six gene variants with an average allele frequency of 0.59 in cases and 0.54 in controls. The mean allele specific relative risk (ASRR) for these variants is 1.42 (range 1.1–1.8). Initial results from genome‐wide association studies tend to confirm this estimate of effect size. Using the characteristics of these variants as a guide, a 30 allele model for bipolar illness is presented in which the modal affected person would carry 22 susceptibility variants, and the median unaffected person would carry 15. In a comparable model with 100 alleles, the modal affected person would carry 62 susceptibility variants compared with a median of 50 in unaffecteds. To the extent that common gene variants are associated with bipolar disorder they may be expected to also be widely distributed in the general population. As the neurobiology of replicated candidate genes is considered, models of potentially relevant biological pathways may be constructed. © 2008 Wiley‐Liss, Inc.
Comprehensive analysis of tagging sequence variants in DTNBP1 shows no association with schizophrenia or with its composite neurocognitive endophenotypes
Authors: Peters Kirsten , Wiltshire Steven , Henders Anjali K. , Dragović Milan , Badcock Johanna C. , Chandler David , Howell Sarah , Ellis Chris , Bouwer Sonja , Montgomery Grant W. , Palmer Lyle J. , Kalaydjieva Luba , Jablensky Assen 
Published: March 2008

AbstractIn a previous study we identified a relatively homogeneous subtype of schizophrenia characterized by pervasive cognitive deficit, which was the exclusive contributor to our findings of linkage to 6p25‐p24. The 6p region contains Dysbindin (DTNBP1), considered to be one of the major schizophrenia candidate genes. While multiple studies have reported association between genetic variation in DTNBP1 and schizophrenia, the findings have been inconsistent and controversial, leading to recent calls for systematic re‐examination and unambiguous evidence of association. To address this, we have undertaken a comprehensive survey of common genetic variation within DTNBP1 and its association with schizophrenia, using a HapMap‐based gene‐tagging approach. We genotyped 39 tSNPs in a sample of 336 cases and 172 controls of Anglo‐Irish ancestry, with the phenotype defined as clinical schizophrenia, and as composite neurocognitive endophenotypes. Allele and haplotype frequencies, and LD structure in our control sample were similar to those in other European populations. Using multivariate generalized linear modeling, we observed no significant association between any tSNP and any outcome variable. Association with haplotypes was examined across the gene and in the previously associated 5′ region. Neither global haplotype tests, nor specific analysis of the “risk” haplotype previously reported in an ethnically related population, the Irish high‐density schizophrenia families, showed significant evidence of association with schizophrenia or with the neurocognitive endophenotypes in our sample. The framework and results of this study should facilitate further attempts at re‐analysis of DTNBP1, in terms of standardized approaches to both phenotype definition and analysis of genetic variation. © 2008 Wiley‐Liss, Inc.
Exogenous Agents that Target Transmembrane Domains of Proteins
Authors: Yin Hang 
Published: March 2008

AbstractAlthough membrane proteins account for approximately one third of all proteins encoded in the human genome, the functions and structures of their transmembrane domains are much less understood than the water‐soluble regions. A major hurdle in studying these transmembrane domains is the lack of appropriate exogenous agents that can be used as specific probes. Despite the daunting challenges, major strides have recently been made in targeting the transmembrane domains of a variety of membrane proteins. High affinity and selectivity have been achieved in model biophysical systems, membranes of bacteria, and mammalian cells.
Testing the Ratio of Two Poisson Rates
Authors: Gu Kangxia , Ng Hon Keung Tony , Tang Man Lai , Schucany William R. 
Published: March 2008

AbstractIn this paper we compare the properties of four different general approaches for testing the ratio of two Poisson rates. Asymptotically normal tests, tests based on approximate p ‐values, exact conditional tests, and a likelihood ratio test are considered. The properties and power performance of these tests are studied by a Monte Carlo simulation experiment. Sample size calculation formulae are given for each of the test procedures and their validities are studied. Some recommendations favoring the likelihood ratio and certain asymptotic tests are based on these simulation results. Finally, all of the test procedures are illustrated with two real life medical examples. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Identification of major alkaloids and steroidal saponins in rat serum by HPLC‐diode array detection‐MS/MS following oral administration of Huangbai‐Zhimu herb‐pair Extract
Authors: Ma Chunhui , Fan Mingsong , Tang Yihong , Li Zhixiong , Sun Zhaolin , Ye Guan , Huang Chenggang 
Published: March 2008

AbstractHuangbai‐Zhimu herb‐pair (HBZMHP) is a widely used Chinese traditional medicine formula in treating various diseases; however, its active components have remained unknown. In this paper, serum chemistry and combined high‐performance liquid chromatography (HPLC), diode‐array detection and mass‐spectrometry (MS) techniques were used to study the constituents of HBZMHP extract absorbed into rat serum after oral administration. A total of nine characteristic HPLC peaks in the TIC chromatograms were identified as magnoflorine (1), menisperine (2), palmatine (3), berberine (4), timosaponin N or timosaponin E1 (5), timosaponin D (6), timosaponin BIII, anemarsaponin C or xilingsaponin B (7) timosaponin BII (8) and timosaponin AIII (9). All of the identified peaks were constituents of HBZMHP extract. The results narrow the range of active compounds to be found in HBZMHP extract, and pave the way for the follow‐up action mechanism research. Copyright © 2008 John Wiley & Sons, Ltd.
New applications of cyclodextrins in electrically driven chromatographic systems: a review
Authors: Cserháti T. 
Published: March 2008

AbstractThe new achievements in the employment of native and derivatised cyclodextrins in various electrically driven chromatographic systems are compiled. Cyclodextrin‐assisted separation techniques are concisely described and critically evaluated with special emphasis on the separation of enantiomer pairs. Copyright © 2008 John Wiley & Sons, Ltd.
Simultaneous determination of β‐blockers in human plasma using liquid chromatography–tandem mass spectrometry
Authors: Umezawa Hironobu , Lee Xiao‐Pen , Arima Yoshiko , Hasegawa Chika , Izawa Hikaru , Kumazawa Takeshi , Sato Keizo 
Published: March 2008

AbstractA detailed procedure for the analysis of four β‐blockers, acebutolol, labetalol, metoprolol and propranolol, in human plasma by high‐performance liquid chromatography (LC)–tandem mass spectrometry (MS‐MS) using an MSpak GF column, which enables direct injection of crude plasma samples, is presented. Protein and/or macromolecule matrix compounds were eluted first from the column, while the drugs were retained on the polymer stationary phase of the MSpak GF column. The analytes retained on the column were then eluted into an acetonitrile‐rich mobile phase using a gradient separation technique. All drugs showed base peak ions due to [M + H]+ ions by LC‐MS with positive ion electrospray ionization, and the product ions were produced from each [M + H]+ ion by LC‐MS‐MS. Quantification was performed by selected reaction monitoring. The recoveries of the four β‐blockers spiked into plasma were 73.5–89.9%. The regression equations for all compounds showed excellent linearity in the range 10–1000 ng/mL of plasma, with the exception of propranolol (10–800 ng/mL). The limits of detection and quantification for each drug were 1–3 and 10 ng/mL, respectively, of plasma. The intra‐ and inter‐day coefficients of variation for all drugs in plasma were not greater than 10.9%. Copyright © 2008 John Wiley & Sons, Ltd.