bluuebunny/crossref_metadata_2025_split huggingface dataset:
HEAVY CHAINS OF MURINE SPLENOCYTE MEMBRANE IMMUNOGLOBULINS: A COMPARISON WITH THE HEAVY CHAINS OF HUMAN AND TOAD SERUM IMMUNOGLOBULINS
Authors: Warr G. W. , Marchalonis J. J. 
Published: April 2007

SUMMARYThe mobilities of murine splenocyte surface immunoglobulin heavy chains were compared by polyacrylamide gel electrophoresis in SDS‐containing buffers, with those of the heavy chains of human IgM, IgG, and IgD, and toad IgY. Human δ‐chain showed a mobility only slightly faster than that of human μ‐chain, and required double‐labelling techniques for unequivocal resolution. The mobility of the slower murine splenocyte surface heavy chain was identical to that of human μ‐chain, but that of the second splenocyte heavy chain was significantly faster than that of human δ‐chain, and similar to that of the heavy chain of toad IgY. Although the second murine splenocyte heavy chain is clearly distinct from μ‐chain, no physico‐chemical evidence exists which relates it directly to human δ‐chain.
GENETIC AND IMMUNOLOGICAL ASPECTS OF LITTER SIZE IN THE MOUSE
Authors: Hetherington C. M. , Humber D. P. , Clarke Ann G. 
Published: April 2007

SUMMARYThe effects of antigenic differences between mother and fetus on implantation number and on post‐implantation mortality were studied. No evidence was found to support the hypothesis that these two measurements were affected by such antigenic differences or by prior immunization of the mother to paternal antigens.
FAILURE TO SUPPRESS THETA ANTIGENIC EXPRESSION IN PROGENY DERIVED FROM PRE‐IMMUNIZED MATERNAL RECIPIENTS
Authors: Braun Colette , Mahouy G. , Bona C. , Goujet‐Zalc Cécile , Tuffrey Maureen , Crewe Pamela , Barnes R. 
Published: April 2007

SUMMARYOne possible theory concerning the success of the fetus as an allograft has been attributed to maternal modification of foreign fetal antigenic expression. In this respect progeny derived from pre‐immunized maternal mouse recipients, have been examined for any modification (reduction) of corresponding θ antigen determinants. Two major groups of mice were examined. The first group of embryo transplantation derived AKR homozygotes born from pre‐immunized CBA recipients whilst producing the corresponding anti‐θAKR antibody activity. The second group of naturally derived reciprocal (CBA × AKR)FI heterozygotes were also born from pre‐immunized maternal recipients.In neither group was θ expression found to be modified and the significance of this finding is discussed in respect of other situations where fetal antigenic expression is known to be altered by maternal influence.
CHEMOTHERAPY—ONE OF THE CAUSES OF TRANSIENT LOSS OF HLA ANTIGENS AND LYMPHOCYTE POLYREACTIVITY IN PATIENTS WITH BLOOD DISEASES AND MALIGNANCIES
Authors: Májský A. , Jakoubková J. , Abrahámová J. 
Published: April 2007

SUMMARYModifications of HLA antigens (transient loss or polyreactivity) were found in thirty‐two of fifty‐five examined patients with blood diseases (leukaemia, reticulosis, reticulo‐ and lymphosarcoma, lymphogranuloma, erythroblastoma) and malignant tumours. In two cases of acute myelosis transient alteration of HLA‐A 2 antigen in HLA‐A 28 was demonstrated. The relationship of HLA antigenic modification to chemotherapy was established, both by analysis of individual cases and by statistical evaluation of serological results in patients with or without chemotherapy (0.01 < P < 0.001). Chemotherapy is thus one of the causes for the development of HLA antigen modifications in blood diseases and malignant tumours.
THE INVOLVEMENT OF A SUPPRESSOR MECHANISM IN NEONATALLY INDUCED ALLOGRAFT TOLERANCE IN MICE
Authors: Rieger M. , Hilgert I. 
Published: April 2007

SUMMARYThe possible involvement of a suppressor cell mechanism in neonatally induced allograft tolerance was tested in two different mouse‐strain combinations. In an H‐2 incompatible donor‐recipient combination presented by the congeneic strains B10.D2 and B10.D2(M504), adoptive transfer of tolerance with 5 × 107 spleen cells to syngeneic sublethally (400 R) irradiated recipients was successful resulting in a markedly prolonged test graft survival or even take. The result of tests for negative tolerance (which should be susceptible to abolition by means of cells from normally reactive donors) did not indicate that neonatally induced tolerance across the given barrier rested on this principle. The suppressor mechanism seemed to be involved in neonatally induced allograft tolerance also in the other strain combination (B10–40NX).
A LINKAGE STUDY OF RABBIT SERUM HIGH DENSITY LIPOPROTEIN (HDL) ALLOTYPES
Authors: Børresen Anne‐Lise , Berg K. , Kindt T. J. 
Published: April 2007

SUMMARYClose linkage between the two allotypic systems of rabbit serum high density lipoprotein (HDL), Hl 1 and R 67, has been confidently excluded, the recombination fraction being at least 0.20.No suggestion of linkage between either HDL allotype and the immunoglobulin allotypes a1a2a3/b4b9, or the red blood cell system (RBC) ADF was obtained.Close linkage was confidently excluded for the Hl 1–ADF, H1 1–a1a2a3, R 67–ADF, R 67–a1a2a3 R 67–b4b9, a1a2a3‐b4 b9, and b4b9‐ADF relationships.
THE KINETICS OF IgG AND IgM ANTIBODY‐FORMING CELLS IN ACI AND F 344 RATS IMMUNIZED WITH POLY (Glu52Lys33Tyr15)
Authors: Shonnard J. W. , Davis B. K. , Ladoulis C. T. , iii Gill T. J. 
Published: April 2007

SUMMARYThe cellular kinetics of antibody production in high and low responder rats immunized with poly(Glu52Lys33Tyr15) or with poly(Glu52Lys33Tyr15)/MeBSA were characterized: serum antibody and IgG and IgM antibody‐forming cells in the spleen and in selected lymph nodes were assayed in male and female rats following immunization by several routes. Aggregation of the antigen with MeBSA enabled the poorly responding F344 rats to produce antibody, which was almost exclusively IgG. High responder ACI rats, under the same conditions, produced antibody of both IgG and IgM classes. These data suggest that in low responders one defect, possibly at the T‐cell level, can be overcome by aggregation but that a second defect, involving the regulation of IgM production, still exists.
THE AVIDITY OF IgM ANTIBODY IN HIGH AND LOW RESPONDER RATS
Authors: Davis B. K. , Shonnard J. W. , iii Gill T. J. 
Published: April 2007

SUMMARYThis study examined IgM antibody produced by highly responding ACI and poorly responding F344 rats following immunization with poly(Glu52Lys33Tyr15) or poly(Glu32Lys33Tyr15) aggregated with methylated bovine serum albumin (MeBSA). The ACI rats produced both IgM and IgG plaque‐forming cells (PFC) following immunization with either form of antigen. The F344 rats did not respond to unaggregated poly(Glu52Lys33Tyr15), but they produced significant amounts of IgG PFC and extremely small amounts of IgM PFC after immunization with poly(Glu52Lys33Tyr15)/MeBSA. Both high and low responder rats had similar kinetic profiles of IgM antibody production, and this antibody had nearly identical avidity in both strains with no evidence for any maturation in avidity. thus, one of the genetic defects in the antibody response to poly(Glu52Lys33Tyr15) is an inability of the F344 strain to produce large amounts of IgM in response to this antigen.
STUDIES ON NON‐H‐2 LINKED LYMPHOCYTE ACTIVATING DETERMINANTS I. DESCRIPTION OF THE CELL TYPE BEARING THE MLS PRODUCT
Authors: Ahmed A. , Scher I. , Smith A. H. , Sell K. W. 
Published: April 2007

SUMMARYThe non‐H‐2 linked, lymphocyte activating determinants (LADs), which are coded by the minor (histocompatibility) lymphocyte stimulating locus (Mls), were detected on B lymphocytes, but not on immunoglobulin (Ig) negative or on theta positive T lymphocytes. These determinants, like the complement receptor and surface IgD, develop late in neonatal life. Thus, the Mls coded LADs mark a population of B lymphocytes which are not present in the spleens of newborn to 2‐week‐old mice. Studies of B lymphocytes derived from the spleens of adult mice indicated that the cells that bear the Mls coded LADs have a high density of surface Ig and possess the complement receptor.
QUANTITATIVE STUDIES OF Gm ALLOTYPES II. G1m(1), G3m(5) AND G3m(21) IN SERA FROM HEALTHY CAUCASOID BLOOD DONORS, AND IN A FAMILY WITH THE INHERITANCE OF A GENE RESPONSIBLE FOR A WEAK Gm1, 17, 21, HAPLOTYPE
Authors: Rivat L. , Salier J. P. , North M. L. , Oberling F. R. 
Published: April 2007

SUMMARYThe quantitative expression of three allotypes–Glm(1), G3m(5) and G3m(21)–has been studied in normal caucasoid sera. A gene dosage effect, previously described for all of these allotypes, is not noticed for G3m(5) in the present study. The different content of G3m(5) and G3m(21) IgG 3 molecules in heterozygous Gm5/Gm21 sera has been verified: these contents are respectively 75% and 25% of the IgG3 content.The same allotypes have been studied in a family which shows the inheritance of a weak Gm1, 17; 21 haplotype. The gene responsible for this abnormality is probably a new regulatory gene, and is transmitted without the ‘aimed’ haplotype.
COMPARISON OF HAPLOTYPES OF THE MAJOR HISTOCOMPATIBILITY COMPLEX IN THE RAT I. THE Ag‐B7 (H‐18) AND Ag‐B8 (H‐1k) HAPLOTYPES
Authors: &Scaron;tark O. , Günther E. , Kunz H. W. , III Gill T. J. 
Published: April 2007

SUMMARYTwo haplotypes of the major histocompatibility complex of the rat, Ag‐B7 and Ag‐B8, have been compared with known H‐1 haplotypes using the F1 skin‐graft test and the dextran haemagglutination test. Both of these Ag‐B haplotypes were different from the known H‐1 haplotypes and determined different private specificities. The Ag‐B7 haplotype was denoted as H‐1g and the Ag‐B8 haplotype as H‐1k. The complex structure of the serologically detected antigenic products of these haplotypes was determined by means of H‐1 congenic lines.
COMPLEMENT FIXATION ANTIBODIES TO GLYCOSPHINGOLIPIDS IN SERA OF RARE BLOOD GROUP p AND Pk PHENOTYPES
Authors: Kato M. , Kubo S. , Naiki M. 
Published: April 2007

SUMMARYBlood group P antigen and Pk antigen were recently identified as glycosphingolipid globoside, GalNAc(β, 1→3)Gal(α, 1→4)Gas(β, 1→4)Glc(β, 1→1)ceramide, and trihexosylceramide, Gal(α, 1→4)Gal(β, 1→4)Gld(β, 1→1)ceramide, respectively (Naiki & Marcus, 1974). The presence of antibodies to both antigens in the sera from rare p donors and antibodies to P antigen in the serum from a rare Pk donor were first demonstrated by the complement fixation test with the optimal antigen preparations containing each purified glycolipid, lecithin and cholesterol. In the serum from a p donor, most of antibody population of anti‐P was IgM and was cross‐reacted to Forssman glycolipid, GalNAc(α, 1→3)GalNAc(β, 1→3)Gal(α, 1→4)Gal(β, 1→4)Glc(β, 1→1) ceramide, but the rest of the anti‐P antibodies and most of anti‐Pk antibodies were IgG and had marked specificities for globoside and trihexosylceramide, respectively.
INFLUENCE OF THE MAJOR HISTOCOMPATIBILITY COMPLEX IN THE PIG (SLA) ON SERUM HAEMOLYTIC COMPLEMENT LEVELS
Authors: Vaiman M. , Hauptmann G. , Mayer Simone 
Published: April 2007

SUMMARYSera from fourty‐six non‐congenic adult pigs from one inter‐related herd were tested for their haemolytic serum complement levels. A comparison of these data with the major histocompatibility complex (SLA) genotypes of these animals resulted in the demonstration of highly significant differences in lytic activity between sera obtained from animals of two distinct SLA haplotypes. These data showed a high correlation between the SLA complex and the level of haemolytic activity.
SLB, A NEW ALLOANTIGENIC SYSTEM OF THE PIG
Authors: Hruban V. , Hradecký J. , Pazdera J. , Simon M. , Veselský L. 
Published: April 2007

SUMMARYAn alloantigen segregating in the double back‐cross families, distinct from serologically determinable transplantation antigens controlled by the major histocompatibility complex (SLA), was detected in pigs by the complementdependent lymphocytotoxic technique. The system was designated SLB and its product (antigen SLB‐Al) was demonstrated in all lymphocytes from the lymph nodes, thymus and peripheral blood, but not in the erythrocytes. Back‐cross matings supplied evidence of the dominant heredity of SLB‐Al. Detection of further SLB antigens was unsuccessful, so that only two alleles (SLB‐Al and SLB‐A‐) could be determined in families. Double back‐cross families revealed a close linkage between the SLB locus and the L blood group locus. Maximum lod score values were calculated in recombination fraction θ= 0.10.
ASYMMETRY IN THE SEROLOGICAL RESPONSE AND MIXED LYMPHOCYTE REACTIONS BETWEEN C57B1/6 AND THE CONGENIC MUTANT C57B1/6. CH‐2ba[H(Z1)]
Authors: Chauvenet P. H. , Amos D. B. , Smith R. T. 
Published: April 2007

SUMMARYAsymmetry in the relationship between the H‐2K mutant strain C57B1/6. CH‐2ba(H‐2ba) and the wild‐type congenic C57B1/6 has been demonstrated both in MLR and serologically by haemagglutination. MLR between these strains, when B6 was the responder, was as strong as that toward allogeneic stimulator cells: H‐2bawas regularly less responsive toward B6. Responses in both directions were increased, in terms of augmented proliferative responses, by prior immunization. In this context the MLR resembles that towards minor H‐locus antigens rather than those controlled by the H‐2 locus. Immunization of (H‐2ba× BALB/c)F1hybrids with B6 lymphoid cells induced the production of a haemagglutinating antibody not directed toward any known H‐2 specificity. The B6 haemagglutinogen, termed He, was present on B6 lymphoid as well as red blood cells. Segregation studies of F2and back‐cross progeny of (H‐2bax BALB/c)F1hybrids suggest that the response to He is controlled by two Ir genes, one of which is linked to H‐2.
HISTOCOMPATIBILITY DIFFERENCE BETWEEN C3HfeB/HeN AND C3H/HeN MICE: TUMOUR INDUCED IN C3HfeB/HeN MICE EXPRESSES C3H/HeN‐ASSOCIATED ALLOANTIGEN
Authors: Martin W. J. , Gipson T. G. , Conliffe M. A. , Cotton W. G. , Dove L. F. , Rice J. M. 
Published: April 2007

SUMMARYA transplacentally induced lung tumour of C3HfeB/HeN mouse origin expresses, as a tumour‐associated antigen, a normal tissue component of strain A mice. The genetic locus coding for this alloantigen has been shown to be linked to the H‐2 major histocompatibility complex. In the present study we demonstrate that this antigen is also expressed on normal tissues of C3H/HeN mice. Skin grafts exchanged between C3HfeB/HeN and C3H/HeN mice are reciprocally rejected at approximately 3 weeks after grafting. C3HfeB/HeN mice were derived from C3H/HeN mice in 1945. These strains have apparently deviated since then in their genetic regulation of the expression of the MHC‐linked genetic locus. The finding of the C3H/HeN‐associated antigen on a C3HfeB/HeN mouse‐derived lung tumour indicates that this deviation is reversible.
THE GENETICS OF AN EXPANDED SECRETOR SYSTEM
Authors: Kimberling W. J. 
Published: April 2007

SummaryThe genetics of salivary secretion of ABH blood group substance was investigated. Eight secretor phenotypes were determined by Sephadex G‐100 chromatography. Presence or absence of three different fractions were shown to be controlled by three different secretor gene loci. These loci are called Sec1, Sec2 and Sec3. Sec1 controls expression of the traditional secretor status. Sec2 and Sec3 are linked, but distinct, loci controlling the expression of low molecular weight ABH substance in human saliva. A dominant mode of inheritance for the Sec2 and Sec3 systems is described.
DIFFERENTIAL RADIOLABELLING OF LYMPHOCYTE MEMBRANE ALLOANTIGENS AND IMMUNOGLOBULINS: VARIATION OF H2O2 CONCENTRATION DURING LACTOPEROXIDASE CATALYZED CELL SURFACE RADIO‐IODINATION
Authors: Emerson S. G. , Reilly Patricia , Cone R. E. 
Published: April 2007

SummaryThe effect of H2O2 concentration on lactoperoxidase catalyzed cell surface radio‐iodination and subsequent isolation of Murine splenic lymphocyte Ia, H‐2K and Lyb‐3 surface antigens and membrane immunoglobulins was studied. For most membrane polypeptides analyzed 0.3 mM H2O2 proved to be optimal for the recovery of radiolabelled antigens from detergent lysates of labelled cells by immunoprecipitation. Marked variations among surface antigens and membrane immunoglobulin polypeptide chains were observed for the iodination and recovery of these proteins above and below the optimal peroxide concentration. The results suggest that cell surface radio‐iodination conditions should be standardized to the requirements of the particular membrane protein being studied. The differential iodination and recovery of discrete membrane components above and below optimal conditions may prove useful in the analysis of surface membrane protein structure and membrane association.
COMPARISON OF THE HAPLOTYPES OF THE MAJOR HISTOCOMPATIBILITY COMPLEX IN THE RAT IV. THE SIX ORIGINAL AG‐B HAPLOTYPES
Authors: ŝTark O. , Kunz H. W. , Gill T. J. 
Published: April 2007

SummaryThe six original haplotypes described in the Ag‐B system were compared with their counterparts in the H‐1 system. Antisera to the Ag‐B haplotypes raised in inbred rats and antisera to H‐1 haplotypes raised in congenic lines were tested against various panels of cell from inbred and congenic lines by the dextran and Ficoll haemagglutination methods. The private and strong public specificities detected in both systems were the same, but there were some minor differences in the intermediate and weak reactivities detected. The cross‐reactivity of the antisera raised in inbred rats was broader than that of antisera raised in congenic lines. The identity of the antigenic products detected in the two systems by the dextran and Ficoll tests was further confirmed by a variety of absorption analyses and by F1 tests. This study completes the systematic serological comparison of the haplotypes of the major histocompatibility complex of the rat described originally in the Ag‐B and H‐1 systems.
IMMUNOGENETIC AND IMMUNOCHEMICAL STUDIES OF H‐2 ANTIGENS OF FOREIGN HAPLOTYPES ON TUMOUR CELLS
Authors: Festenstein H. , Schmidt W. , Testorelli C. , Giorgi L. De , Morelli O. , Matossian‐Rogers A. , Atfield G. 
Published: April 2007

SummaryThe polymorphism of histocompatibility antigens is usually explained by classical Mendelian laws, which allow the inheritance of one allele per locus. Thus each individual would express two antigens for each locus of the pair of relevant homologous chromosomes, one from each parent.Another explanation is that the structural genes of all the different haplotypes are all in tandem. Regulatory genes would then determine the polymorphism by mimicking Mendelian inheritance–allowing only the relevant gene products for a particular haplotype to be expressed. If correct, one might expect the mechanism to fail sometimes, and silent genes of foreign haplotypes to be derepressed, allowing H‐2 antigens of the wrong haplotype to become expressed.In the light of this hypothesis (Martin, 1975; Amos, 1971; Bodmer, 1975; Festenstein, 1978; Garrido et al., 1976a,b), the original findings in our laboratory of extra foreign ‘H‐2‐like’ determinants on tumour cells passaged in vitro and in vivo with and without virus are considered rather important (Festenstein, 1978; Garrido et al., 1976a,b); not only because they could lead to a better understanding of the genetic basis of MHS polymorphism, but also because of its implication for the surveillance of tumours (Garrido et al., 1976b; Gomard et al., 1977; Blank et al., 1976; Parmiani & Invernizzi, 1975) and microbially damaged cells (Doherty & Zinkernagel, 1975). These extra determinants were tested by various serological techniques and assays of cell mediated immunity.
BIOSYNTHESIS OF HUMAN BLOOD GROUP T‐, N‐ AND M‐SPECIFIC IMMUNODETERMINANTS ON HUMAN ERYTHROCYTE ANTIGENS
Authors: Desai P. R. , Springer G. F. 
Published: April 2007

SummaryWe synthesized on Tn erythrocytes with human sera, UDP‐Gal, and activators T‐specific haptenic structures in satisfactory yield. The specificity of this biosynthesis was ascertained by agglutination with human and animal anti‐T, by specific absorption of human anti‐T as well as by agglutination inhibition assays.With isolated human erythrocyte T antigen as substrate we synthesized N‐ and M‐specific structures with sera from individual human donors in presence of CMP‐sialic acid by incubation for 24 hr at 37°C. Serology on the recovered product was carried out with nineteen monospecific human and animal sera under strictly standardized and controlled conditions with the mandatory tube assay. All M‐ as well as N‐derived T antigens tested acquired N specificity with all transferase sera of all MN types. In contrast, M‐activation of M‐ and N‐derived T antigens occurred only if the transferase donor had the M gene. The nine M transferase sera used all gave M‐activation of MM‐ and NN‐derived T antigens. None of twelve transferase sera from NN donors M‐activated any T antigen. NN antigen was transformed to a M‐specific one by all transferase sera from MM donors but by none from NN donors.We have not yet established the biochemical‐genetic relation of M to N; N may be the immediate precursor of M or M may originate directly from T. The sialytransferase responsible for M activation may be a N transferase ‘modified’ by the M gene product or an entirely different sialyltransferase.
EXPRESSION OF FOREIGN H‐2‐LIKE ANTIGENS BY A CHEMICALLY‐INDUCED MURINE TUMOUR (MCG4)
Authors: Schirrmacher V. , Garrido F. , Garcia‐Olivares F. , Perez M. , Torres M. Dolores 
Published: April 2007

SummaryAlien H‐2k‐like antigens were found to be expressed by a methylcholanthrene induced tumour of BALB/c (H‐2d) origin. H‐2 specificities of the k haplotype were detected on this tumour by a variety of serological techiques, including 51Cr‐release cytotoxicity, microradioassay and absorption. The antisera employed were conventional polyspecific alloantisera, typing sera with restricted specificty and monoclonal hybridoma‐derived anti‐H‐2k antibodies.The tumour has a low expression of the private specificty 31, which characterizes Kd molecules, and does not seem to express the private specificities of Dd, Kk and Dk molecules. It appears to express predominantly alien H‐2‐like antigens which are very similar to but not identical with normal H‐2k molecules.
THE EFFECT OF MATERNAL RESPONDER STATUS ON THE GENETIC CONTROL OF THE ANTIBODY RESPONSE
Authors: Sieber Jr W. K. , Wagener Diane K. , Gill T. J. , Kunz H. W. , Eddey G. E. 
Published: April 2007

SummaryVarious genetic models were examined with regard to the control of the antibody response in rats. Distributions of the response to poly(Glu52Lys33Tyr15) were determined in the inbred ACI (high responder) and F344 (low responder) strains and in the F1, F2 and backcross generations. Falconer's test for the effective number of genes showed that there was a larger number of genes involved if the maternal parent were the high responder strain. Studies in mating combinations involving high and moderate responders showed that the effective number of genes influencing the antibody response was much lower than in the mating between the high and low responders. Theoretical distributions of antibody response levels were generated using Monte Carlo techniques. The Kolmogorov‐Smirnov goodness‐of‐fit test indicated that a three‐gene model best fitted the matings involving the ACI female and that a two‐gene model best accounted for matings involving the F344 female. These calculations indicate that the antibody response is a complex, multifactorial trait whose expression is significantly affected by the responder status of the maternal strain.
HD50 ASSAY EVALUATION OF THE ANTIGEN Fy3 DEPRESSION IN Fyx INDIVIDUALS
Authors: Habibi B. , Perrier P. , Salmon C. 
Published: April 2007

SummaryHD50 assays for the antigens Fyb and Fy3 were performed in a large number of Fyx homozygous or heterozygous individuals. A full correlation was found in quantitative expression of Fyb and Fy3 favouring the hypothesis of a Fybw Fy3w gene complex in the Duffy blood group system.