bluuebunny/crossref_metadata_2025_split huggingface dataset:
The long‐term effect of periodontitis treatment on changes in blood inflammatory markers in patients with generalized aggressive periodontitis
Authors: Zeng Xiancheng , Wang Xiane , Guan Xiaoyuan , Feng Xianghui , Lu Ruifang , Meng Huanxin 
Published: March 2024

AbstractBackgroundPeriodontitis is characterized by local inflammatory conditions in the periodontium, its severe form has been associated with elevated systemic inflammatory markers. However, the long‐term effects of periodontal inflammation control on systemic inflammatory markers are unclear.ObjectiveThis study aimed to investigate the long‐term effects of periodontal therapy on the levels of peripheral venous blood inflammatory markers in patients with generalized aggressive periodontitis (GAgP), all of whom were now diagnosed as Stage III or IV Grade C periodontitis.MethodsPatients with GAgP were consecutively recruited from April 2013 to August 2014 (T0). Active periodontal treatment (APT) was provided, and follow‐ups were conducted over a 3‐ to 5‐year period (T1). Clinical parameters were assessed and fasting venous blood was collected at T0 and T1. Complete blood cell counts were obtained, and biochemical analyses were performed to evaluate the levels of serum components. The correlations between probing depth (PD) and hematological parameters were analyzed.ResultsA total of 49 patients with GAgP completed APT and follow‐ups. Probing depth (PD) reduced from 5.10 ± 1.07 mm at T0 to 3.15 ± 0.65 mm at T1. For every 1‐mm reduction in PD after treatment, the neutrophil count, neutrophil‐lymphocyte ratio, and total protein concentration were reduced by 0.33 × 109/L, 0.26, and 1.18 g/L, respectively. In contrast, the albumin/globulin ratio increased by 0.10.ConclusionThis study indicated that periodontal therapy may have beneficial effects on peripheral venous blood inflammatory markers in patients with GAgP during long‐term observation.
An expedited model for identifying potential patients with periodic leg movements
Authors: Chen Po‐Yueh , Lin Shang‐Yang , Wu Chung‐Sheng , Hung Shih‐Han , Chen David Hsin‐Kuang , Liu Wen‐Te , Lin Yi‐Chih 
Published: March 2024

SummaryPeriodic leg movements during sleep (PLMS) may have crucial consequences in adults. This study aimed to identify baseline characteristics, symptoms, or questionnaires that could help to identify sleep‐disordered breathing patients with significant PLMS. Patients aged 20–80 years who underwent polysomnography for assessing sleep disturbance were included. Various factors such as sex, age, body measurements, symptoms, apnea–hypopnea index (AHI), and sleep quality scales were analysed to determine the presence of PLMS. The study included 1480 patients with a mean age of 46.4 ± 13.4 years, among whom 110 (7.4%) had significant PLMS with a PLM index of 15 or higher. There were no significant differences observed in terms of sex or BMI between patients with and without significant PLMS. However, the odds ratios (OR) for PLMS were 4.33, 4.41, and 4.23 in patients who were aged over 50 years, had insomnia, or had an ESS score of less than 10, respectively. Notably, the OR increased up to 67.89 times in patients who presented with all three risk factors. Our analysis identified significant risk factors for PLMS: age over 50, self‐reported insomnia, and lower daytime sleepiness levels. These findings aid in identifying potential PLMS patients, facilitating confirmatory examinations and managing associated comorbidities.
Spatial and temporal recruitment variability of sandy subtidal megabenthic populations on an open coastline influenced by a tsunami caused by the 2011 Tohoku earthquake
Authors: Sugiura Daisuke , Fukui‐Hashizume Shotaro , Noro Hideki , Fujikawa Yoshikazu 
Published: March 2024

AbstractThe spatial distribution and size structure of two infaunal filter‐feeding bivalves, that is, Sakhalin surf clam Spisula sachalinensis (Schrenck, 1862) and dwarf sunray surf clam Mactra crossei (Dunker, 1877), and an epibenthic deposit feeder, namely the sand dollar Scaphechinus mirabilis (A. Agassiz, 1864), were investigated on an open sandy beach in northern Japan after the tsunami caused by the 2011 Tohoku earthquake. Settlement of S. sachalinensis was relatively abundant in the 2011‐ and 2012‐year classes, but then substantially decreased until the early months of 2013. The 0+‐year‐old distribution was associated mainly with a depth gradient and weakly with the median grain size of the sediment. Mactra crossei had (1) an inverse trend in long‐shore variation in abundance at 2+ years of age and (2) later‐post‐settlement processes that regulated its population dynamics, compared to those of S. sachalinensis. The 2010‐year classes for both Mactridae species survived until 2+ years of age, although their abundance showed a high level of spatial variation. Scaphechinus mirabilis showed fine‐scale spatial variation in their recruitment dynamics. The cross‐shore distribution of S. mirabilis showed a clear ontogenetic shift from shallow to deep water. The cross‐shore distribution of small S. mirabilis (<40 mm in test diameter) overlapped that of the juvenile S. sachalinensis, but their interaction was unclear. Overall, the level of spatial and temporal recruitment variation was relatively high in each species. However, the tsunami has scarcely influenced the cross‐shore distribution and population structure of each species.
N6‐methyladenosine modification of RNA controls dopamine synthesis to influence labour division in ants
Authors: Chen Jie , Guan Ziying , Sun Lina , Fan Xinlin , Wang Desen , Yu Xiaoqiang , Lyu Lihua , Qi Guojun 
Published: March 2024

AbstractThe N6‐methyladenosine (m6A) modification of RNA has been reported to remodel gene expression in response to environmental conditions; however, the biological role of m6A in social insects remains largely unknown. In this study, we explored the role of m6A in the division of labour by worker ants (Solenopsis invicta). We first determined the presence of m6A in RNAs from the brains of worker ants and found that m6A methylation dynamics differed between foragers and nurses. Depletion of m6A methyltransferase or chemical suppression of m6A methylation in foragers resulted in a shift to ‘nurse‐like’ behaviours. Specifically, mRNAs of dopamine receptor 1 (Dop1) and dopamine transporter (DAT) were modified by m6A, and their expression increased dopamine levels to promote the behavioural transition from foragers to nurses. The abundance of Dop1 and DAT mRNAs and their stability were reduced by the inhibition of m6A modification caused by the silencing of Mettl3, suggesting that m6A modification in worker ants modulates dopamine synthesis, which regulates labour division. Collectively, our results provide the first example of the epitranscriptomic regulation of labour division in social insects and implicate m6A regulatory mechanism as a potential novel target for controlling red imported fire ants.
DP7‐C/mir‐26a system promotes bone regeneration by remodeling the osteogenic immune microenvironment
Authors: Huang Jie , Yang Yiling , Zhu Yushu , Xiao Xun , Yalikun Kaidiliya , Jiang Xiliang , Yang Li , Mu Yandong 
Published: March 2024

AbstractObjectiveThis study investigates the DP7‐C/miR‐26a complex as a stable entity resulting from the combination of miR‐26a with the immunomodulatory peptide DP7‐C. Our focus is on utilizing DP7‐C loaded with miR‐26a to modulate the immune microenvironment in bone and facilitate osteogenesis.MethodsThe DP7‐C/miR‐26a complex was characterized through transmission electron microscopy, agarose electrophoresis, and nanoparticle size potentiometer analysis. Transfection efficiency and cytotoxicity of DP7‐C were assessed using flow cytometry and the CCK‐8 assay. We validated the effects of DP7‐C/miR‐26a on bone marrow mesenchymal stem cells (BMSCs) and macrophages RAW 264.7 through gene expression and protein synthesis assays. A comprehensive evaluation of appositional bone formation involved micro‐CT imaging, histologic analysis, and immunohistochemical staining.ResultsDP7‐C/miR‐26a, a nanoscale, and low‐toxic cationic complex, demonstrated the ability to enter BMSCs and RAW 264.7 via distinct pathways. The treatment with DP7‐C/miR‐26a significantly increased the synthesis of multiple osteogenesis‐related factors in BMSCs, facilitating calcium nodule formation in vitro. Furthermore, DP7‐C/miR‐26a promoted M1 macrophage polarization toward M2 while suppressing the release of inflammatory factors. Coculture studies corroborated these findings, indicating significant repair of rat skull defects following treatment with DP7‐C/miR‐26a.ConclusionThe DP7‐C/miR‐26a system offers a safer, more efficient, and feasible technical means for treating bone defects.
« La liberté, c'est le vent ». Histoire et humanisme dans Le chant du retour de Vera Feyder
Authors: Niedokos Judyta 
Published: March 2024

RésuméLe présent article se propose d'analyser le lien entre l'histoire et l'humanisme dans une pièce de théâtre de l'écrivaine belge Vera Feyder, intitulée Le chant du retour (1989). Commandé par la ville d'Arras pour célébrer le bicentenaire de la Révolution française et le révolutionnaire arrageois Maximilien de Robespierre, le drame amène dans l'action contemporaine la couche historique à travers l'idée de l'Arbre de la liberté, la reconstruction d'un événement historique ainsi que l'intertextualité assise sur des chansons révolutionnaires. L'idée d'humanisme présente dans la pièce est analysée en référence à ses trois caractéristiques définies par Tzvetan Todorov dans Le jardin imparfait: l'autonomie du je, la finalité du tu et l'universalité des ils. Finalement, l'article analyse le rôle de l'art en tant que porteur d'histoire d'humanisme.
Dermoscopy of hypopigmented macules unveiling genetic diagnosis of tuberous sclerosis complex type 2 in an infant presenting with sacral chordoma
Authors: Sharma Ananya , Aggarwal Bhawana , Kakkar Aanchal , Pandey Niraj Nirmal , Taneja Neha 
Published: March 2024

AbstractA 2‐month‐old male with surgically resected sacral chordoma presented with multiple hypopigmented macules showing characteristic patchy, sharply demarcated areas of pigment network on dermoscopy. These dermoscopic findings were suggestive of the ash‐leaf macules of tuberous sclerosis over other common hypopigmented macules in neonates. Chordomas presenting in early childhood in the sacral location have been reported as a rare manifestation of tuberous sclerosis complex. The combination of these findings led to a diagnosis of tuberous sclerosis, confirmed with the finding of a heterozygous TSC2 gene deletion; treatment with sirolimus resulted in regression of cardiac rhabdomyomas and hypopigmented macules.
Systemic racism and racial inequities in periodontal health: The long journey from upstream determinants to downstream treatment
Authors: Fleming Eleanor , Taylor George W. , Neighbors Harold Woody 
Published: March 2024

AbstractRacial disparities in the prevalence of periodontal disease are consistent and persistent. The epidemiology of periodontal disease demonstrates racial inequities: non‐Hispanic Black (14.7%), Mexican American (13.4%), and other Hispanic adults (7.8%) experience a higher prevalence of severe periodontal disease than non‐Hispanic White adults (5.9%). Epidemiologic and clinical research on periodontal health suffers from the same problem that has plagued the health equity movement, an over emphasis on describing racial inequities coupled with few interventions that reduce racial health inequity. Over the decades that racial inequities in periodontal disease have been observed, many have argued that systemic racism is the fundamental driver of racial health inequity. This paper interrogates the roles of systemic racism, dental education, clinical treatment, and patient behavior in periodontal disease. We describe how, together, these mechanisms contribute to racial disparities in periodontal outcomes. However, it is insufficient for oral health equity scientists to only describe and discuss the negative effects of systemic racism. The imperative is to create antiracist strategies designed to eliminate systemic racism. Health equity scientists must also specify how dental systems operate in a racist manner and create effective clinical strategies designed to reduce racial disparities in periodontal disease.
Professional burnout among expert physicians, patient‐focused care, and trust in top management: Moving forward
Authors: Gabay Gillie 
Published: March 2024

IntroductionProfessional burnout in physicians is perceived as an inevitable occupational hazard inhibiting patient‐focused care, the preferred approach of care, which enhances satisfaction of physicians with their work and improves clinical outcomes. Burnout jeopardizes the physical, mental, and emotional health of physicians, inhibiting high‐quality care. Most individual‐driven interventions and job‐level interventions to reduce burnout proved inefficient or reduced burnout for only a short term. The potential of organizational processes to reduce burnout was acknowledged but is yet to be empirically tested. Drawing on social exchange theory, this study investigates the role of an organizational phenomenon, organizational trust among physicians in top management, on burnout.MethodsData were collected across specialties in 10 out of 20 Israeli public general hospitals. The sample comprised 798 senior expert physicians. Measures were all previously published. Structural equation modeling was performed.ResultsResponse rates ranged from 17% to 77% across the 10 hospitals. Mean burnout was 4.7 (SD = 0.68), mean patient‐focused care was 3.9 (SD = 0.79), and mean organizational trust was 3.7 (SD = 0.84). Mean burnout for women was 5.6 and for physicians from internal medicine was 5.5. The structural equation modeling supported the proposed study model, which explained 45% of burnout. Organizational trust reduced burnout by 14%.DiscussionEfforts to reduce burnout should integrate effective individual‐level and job‐level interventions with building trust among physicians in top management through implementing the paramount professional value of patient‐focused care.ConclusionsPerceiving management, among physicians, as facilitating the value of patient‐focused care led to organizational trust in top management, which was negatively associated with burnout.
The missing ingredient: Medical student insights to inform and enhance learner handover
Authors: Conway Clare , McKeague Helena , Harney Sarah 
Published: March 2024

AbstractBackgroundLearner handover (LH) is the passing on of information about students between educators. In light of broad acceptance that LH can improve learner support experiences and performance outcomes, those involved are seeking greater governance to achieve practical, effective handover implementation. Stakeholder consultation can inform and enable the co‐creation of meaningful, robust practice guidance. This study sought to address the gap in literature around in‐depth learner opinion, a key element so far overlooked.MethodsThis qualitative study (2022) investigated undergraduate medical student perspectives on appropriate tutor information‐sharing at the University of Limerick School of Medicine (ULSoM). The findings build upon an educator focus group study published by the authors (2021). Eleven participants were recruited to represent the typical graduate‐entry medical school programme population across years 1–4 of study. Their understanding and expectations of “learner handover” were explored qualitatively, using online, individual, semi‐structured interviews. Inductive transcript coding and thematic data analysis were applied to illustrate learner insights.FindingsEmergent themes included shared values, individual context and collaborative process, with ideas proposed for specific action around student education, staff training, mental health support, and documented procedures.DiscussionConsent, system transparency, data security and the development of positive handover culture were revealed as current needs. Student perspectives, together existing LH literature and highlighted aspects of educational theory, allowed the creation a new conceptual LH framework as a foundation for practice improvement.ConclusionThese findings provide clarity and contextual understanding, mainly from a pre‐clinical phase learner standpoint, with pragmatic suggestions to enhance LH appeal.
Experiences of junior doctors who shielded during the COVID‐19 pandemic
Authors: Martin Amy 
Published: March 2024

AbstractBackgroundShielding was introduced to protect clinically extremely vulnerable people during the COVID‐19 pandemic. For junior doctors who had to shield, this meant pausing in‐person clinical duties to protect their health. There is limited literature regarding this, and the available evidence is predominantly surveys or blogs that describe mainly negative experiences including guilt, isolation, inadequate support and Return To Work (RTW) concerns. Exploring the experiences of this group is valuable to understand the impact on them, and their support needs moving forward.MethodsThis was a qualitative study using individual semi‐structured interviews. Three junior doctors were recruited using volunteer and snowball sampling. Interview transcripts were analysed using thematic analysis.FindingsSeven themes were finalised: (1) Professional value, (2) Threatened autonomy, (3) Self‐motivated, (4) Educational impact, (5) Mental health, (6) Inadequate support and (7) Return To Work concerns.DiscussionParticipant experiences largely reflected the evidence base including increased skill and knowledge acquisition, alongside guilt, isolation and inadequate support whilst shielding and upon RTW. These findings add valuable qualitative data to a scarcity of literature. However, caution should be applied when transferring these findings to other junior doctors, noting the small sample and regional setting. A small research grant has been secured for further research with a larger sample size incorporating the supervisor perspective.ConclusionThese findings demonstrate that shielding was a challenging experience for these junior doctors including impacts on mental health and insufficient support. This lack of support requires further attention to refine and strengthen available support structures.
Histoplasma capsulatum tenosynovitis: An unusual presentation in a kidney transplant recipient
Authors: Alza‐Arcila Jhongert , Ramírez‐Sánchez Isabel Cristina , Diaz‐Sanabria Ricardo Augusto 
Published: March 2024

AbstractHistoplasmosis is an expected endemic mycosis in solid organ transplant recipients and occurs as a primary infection, reactivation, or, rarely, acquired from an infected allograft. Reactivation is favored by maintenance immunosuppression or anti‐rejection therapy, which facilitates the appearance of disseminated forms as well as unusual presentations. We present the case of a 66‐year‐old woman with isolated tenosynovitis due to Histoplasma capsulatum 25 years after a kidney transplant.
Collaboration in documentary filmmaking and its discontents: Reflections from the field
Authors: Schrago Sophie 
Published: March 2024

AbstractCollaborative practice can sometimes be flawed and exploitative. Drawing on my ethnographic fieldwork within an Indian Muslim women's organization, my article examines the co‐creative practice and its pitfalls and what it ultimately reveals about reflexivity and the politics of (self)representation. I discuss how my attempt at making a collaborative/co‐authored film project with my research participants became difficult to realize in its theoretical and methodological intent, for the collaborators inevitably fall across different positionalities and accesses to power. Rather than succeeding at co‐writing the film, the experience revealed how the power dynamics can be even more pronounced in collaborative filmmaking practice.
“Come to life” realism: View‐Master reels and the legacy of stereoscopic imperialism
Authors: Guedes Gabbi 
Published: March 2024

AbstractI argue that View‐Master reels upheld the colonial legacy of previous stereoscopic depictions of Indigenous subjects while inaugurating new methods of asserting power in exhibition via its ease of use and “black‐box” structure. Further, focusing on the instrumentalization of stereoscopy allows us to think through how these images intervene in the history of the representation of Indigenous subjects across image media and histories of photographic technology and consumption. In sum, although stereoscopy functions as a marketable tool for narrativizing colonial power, its affective qualities and historical contexts complicate fantasies of unilateral viewing and domination and bring forth histories of resistance.
Time course changes in in vivo muscle mechanical function and Ca2+ regulation of force following experimentally induced gradual ovarian failure in mice
Authors: Hinks Avery , Dalton Benjamin E. , Mashouri Parastoo , Flewwelling Luke D. , Pyle William Glen , Cheng Arthur J. , Power Geoffrey A. 
Published: March 2024

AbstractThe abrupt cessation of ovarian hormone release is associated with declines in muscle contractile function, yet the impact of gradual ovarian failure on muscle contractility across peri‐, early‐ and late‐stage menopause remains unclear. In this study, a 4‐vinylcyclohexene diepoxide (VCD)‐induced ovarian failure mouse model was used to examine time course changes in muscle mechanical function. Plantar flexors of female mice (VCD: n = 10; CON: n = 8) were assessed at 40 (early perimenopause), 80 (late perimenopause), 120 (menopause onset) and 176 (late menopause) days post‐initial VCD injection. A torque–frequency relationship was established across a range of frequencies (10–200 Hz). Isotonic dynamic contractions were elicited against relative loads (10–80% maximal isometric torque) to determine the torque–velocity–power relationship. Mice then performed a fatigue task using intermittent 100 Hz isometric contractions until torque dropped by 60%. Recovery of twitch, 10 Hz and 100 Hz torque were tracked for 10 min post‐task failure. Additionally, intact muscle fibres from the flexor digitorum brevis underwent a fatigue task (50 repetitions at 70 Hz), and 10 and 100 Hz tetanic [Ca2+] were monitored for 10 min afterward. VCD mice exhibited 16% lower twitch torque than controls across all time points. Apart from twitch torque, 10 Hz torque and 10 Hz tetanic [Ca2+], where VCD showed greater values relative to pre‐fatigue during recovery, no significant differences were observed between control and VCD mice during recovery. These results indicate that gradual ovarian failure has minimal detriments to in vivo muscle mechanical function, with minor alterations observed primarily for low‐frequency stimulation during recovery from fatigue.