bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feasibility of super-bore 0.088″ mechanical thrombectomy in M1 vessels smaller than 8 French: Experience in 20 consecutive cases
Authors: Campos Jessica K , Meyer Benjamen M , Khan Muhammad Waqas , Laghari Fahad J , Zarrin David A , Collard de Beaufort Jonathan , Amin Gizal , Golshani Kiarash , Bender Matthew T , Colby Geoffrey P , Lin Li-Mei , Coon Alexander L 
Published: February 2024

Introduction Superbore 0.088″ catheters provide a platform for optimizing aspiration efficiency and flow control during stroke mechanical thrombectomy procedures. New superbore catheters have the distal flexibility necessary to navigate complex neurovascular anatomy while providing the proximal support of traditional 8F catheters. The safety and feasibility of Zoom 88™ superbore angled-tip catheters in the middle cerebral artery (MCA) segments smaller than the catheter diameter have not been previously described. Methods Twenty consecutive cases of acute MCA mechanical thrombectomy were retrospectively identified from the senior authors’ prospectively maintained Institutional Review Board-approved database, in which the Zoom 88 (Imperative Care, Campbell, CA) catheter was successfully navigated to at least the M1 segment. Patient demographics, procedural details, and periprocedural information were analyzed. Rates and averages (standard errors) are generally reported. Results The average National Institutes of Health Stroke Scale at presentation and age were 15 ± 2 and 73 ± 3 years, respectively. The M1 and M2 occlusions were evenly distributed. The average M1 measurements before thrombectomy ranged from 2.36 ± 0.07 mm proximally to 2.00 ± 0.11 mm distally, and after thrombectomy, they ranged from 2.34 ± 0.07 mm proximally to 1.97 ± 0.10 mm distally. First-pass modified thrombolysis in cerebral infarction (mTICI) 2C/3 recanalization was achieved in 40% of cases, and final mTICI 2C/3 recanalization was achieved in 90% of cases. A single case of mild vasospasm was managed with verapamil. No hemorrhagic or periprocedural complications were noted. Conclusion Superbore 0.088″ catheters with flexible distal segments can be safely navigated to the MCA to augment mechanical thrombectomy even when the MCA segment is smaller than the catheter.
Exploring Socioeconomic Disparities in Mandibular Trauma: A Retrospective Cohort Analysis of Patient Profiles and Treatment Outcomes
Authors: Kahler Dylan , Gardella Rebecca , Reddy Sai , Zhao Huaqing , Gerald Mykal , Jones Christine 
Published: February 2024

Study Design Retrospective Chart Review. Objective Mandible fracture is a life-altering event, and its complications can have devastating consequences for patients. Patients are therefore well-served if providers can identify their risk factors and engage strategies to reduce complication risk. The present study examines mandible trauma in an urban tertiary hospital serving an economically disadvantaged population. Methods This review identified all patients undergoing operative repair of traumatic mandible fractures from January 2015 to December 2020. Patient risk factors, operative technique, and surgical complications (including infection, hardware failure, malunion, and mandible nonunion) were analyzed. Results Two hundred and seventy-two patients were identified with mandible fractures; 78.3% of these injuries were related to interpersonal violence; 83.4% of patients were male, and 55.5% were African American. Based on multivariable logistic regression models, increased rates of postoperative complications were observed in patients with increasing Area Deprivation Index (Odds Ratio 1.02), mandible body fracture (OR 3.11), tobacco use disorder (OR 3.75), history of hepatitis C infection (OR 7.35), and discharge to drug and alcohol rehabilitation (OR 23.42). Conclusions For providers treating patients with mandible fractures, the effects of comorbid substance use—including tobacco use—and inadequate discharge disposition (a reflection of financial means and insurance status) should be identified early, and steps to mitigate their consequences should be taken. Providers must recognize that patients with these comorbidities require more patience, support, and attention than patients without these risk factors. Increased engagement with multidisciplinary services such as psychiatry, addiction medicine, primary care, and social work may improve outcomes for these vulnerable patients.
Development of Fixture Layout Optimization for Thin-Walled Parts: A Review
Authors: Liu Changhui , Wang Jing , Zhou Binghai , Yu Jianbo , Zheng Ying , Liu Jianfeng 
Published: February 2024

AbstractAn increasing number of researchers have researched fixture layout optimization for thin-walled part assembly during the past decades. However, few papers systematically review these researches. By analyzing existing literature, this paper summarizes the process of fixture layout optimization and the methods applied. The process of optimization is made up of optimization objective setting, assembly variation/deformation modeling, and fixture layout optimization. This paper makes a review of the fixture layout for thin-walled parts according to these three steps. First, two different kinds of optimization objectives are introduced. Researchers usually consider in-plane variations or out-of-plane deformations when designing objectives. Then, modeling methods for assembly variation and deformation are divided into two categories: Mechanism-based and data-based methods. Several common methods are discussed respectively. After that, optimization algorithms are reviewed systematically. There are two kinds of optimization algorithms: Traditional nonlinear programming and heuristic algorithms. Finally, discussions on the current situation are provided. The research direction of fixture layout optimization in the future is discussed from three aspects: Objective setting, improving modeling accuracy and optimization algorithms. Also, a new research point for fixture layout optimization is discussed. This paper systematically reviews the research on fixture layout optimization for thin-walled parts, and provides a reference for future research in this field.
Highly sensitive therapeutic drug monitoring of infliximab in serum by targeted mass spectrometry in comparison to ELISA data
Authors: Hentschel Andreas , Piontek Gina , Dahlmann Rob , Findeisen Peter , Sakson Roman , Carbow Phil , Renné Thomas , Reinders Yvonne , Sickmann Albert 
Published: February 2024

Abstract
Background
Presently, antibody concentration measurements for patients undergoing treatment are predominantly determined by ELISA, which still comes with known disadvantages. Therefore, our aim was to establish a targeted mass-spectrometric assay enabling the reproducible absolute quantification of peptides from the hypervariable and interaction regions of infliximab.

Methods
Peptides of infliximab were measured post-trypsin digestion and subsequent separation on a Vanquish Horizon UHPLC coupled to a TSQ Altis Triple-Quad mass spectrometer. Normalization and absolute quantification were conducted using stable isotope-synthesized peptides. Calibration curves covering a range of 0.25-50 µg/ml were employed for quantitation.

Results
We demonstrated the substantial influence of peptide selection, choice of hydrolase for digestion, and digestion time on absolute peptide yield (28–44% for peptide 1 and 64–97% for peptide 2). Furthermore, we showed that the generated calibration curves for absolute quantification were highly reproducible and robust (LLOQ1 0.72 µg/ml and LLOQ2 1.00 µg/ml) over several months. In comparison to ELISA values, the absolute values obtained by mass spectrometry often yielded lower results for both targeted peptides.

Conclusions
In this study, a semi-automated workflow was employed and tested with 8 patients and corresponding replicates (n = 3–4). We demonstrated the robust implementation of calibration curves for the absolute quantification of infliximab in patient samples, with coefficients of variation ranging from 0.5 to 9%. Taken together, we have developed a platform enabling the rapid (2 days of sample preparation and 30 min of measurement time per sample) and robust quantification of Infliximab antibody concentration in patients. The use of mass spectrometry also facilitates the straightforward expansion of the method to include additional antibody peptides.
Searching for homozygous haplotype deficiency in Manech Tête Rousse dairy sheep revealed a nonsense variant in the MMUT gene affecting newborn lamb viability
Authors: Ben Braiek Maxime , Moreno-Romieux Carole , André Céline , Astruc Jean-Michel , Bardou Philippe , Bordes Arnaud , Debat Frédéric , Fidelle Francis , Granado-Tajada Itsasne , Hozé Chris , Plisson-Petit Florence , Rivemale François , Sarry Julien , Tadi Némuel , Woloszyn Florent , Fabre Stéphane 
Published: February 2024

Abstract
Background
Recessive deleterious variants are known to segregate in livestock populations, as in humans, and some may be lethal in the homozygous state.

Results
We used phased 50 k single nucleotide polymorphism (SNP) genotypes and pedigree data to scan the genome of 6845 Manech Tête Rousse dairy sheep to search for deficiency in homozygous haplotypes (DHH). Five Manech Tête Rousse deficient homozygous haplotypes (MTRDHH1 to 5) were identified, with a homozygous deficiency ranging from 84 to 100%. These haplotypes are located on Ovis aries chromosome (OAR)1 (MTRDHH2 and 3), OAR10 (MTRDHH4), OAR13 (MTRDHH5), and OAR20 (MTRDHH1), and have carrier frequencies ranging from 7.8 to 16.6%. When comparing at-risk matings between DHH carriers to safe matings between non-carriers, two DHH (MTRDHH1 and 2) were linked with decreased insemination success and/or increased stillbirth incidence. We investigated the MTRDHH1 haplotype, which substantially increased stillbirth rate, and identified a single nucleotide variant (SNV) inducing a premature stop codon (p.Gln409*) in the methylmalonyl-CoA mutase (MMUT) gene by using a whole-genome sequencing approach. We generated homozygous lambs for the MMUT mutation by at-risk mating between heterozygous carriers, and most of them died within the first 24 h after birth without any obvious clinical symptoms. Reverse transcriptase-qPCR and western blotting on post-mortem liver and kidney biological samples showed a decreased expression of MMUT mRNA in the liver and absence of a full-length MMUT protein in the mutant homozygous lambs.

Conclusions
We identified five homozygous deficient haplotypes that are likely to harbor five independent deleterious recessive variants in sheep. One of these was detected in the MMUT gene, which is associated with lamb lethality in the homozygous state. A specific management of these haplotypes/variants in the MTR dairy sheep selection program would help enhance the overall fertility and lamb survival.
Balancing risks and rewards of alternate strategies in the seaward extent, duration and timing of fjord use in contemporary anadromy of brown trout (Salmo trutta)
Authors: Hawley K. L. , Urke H. A. , Kristensen T. , Haugen T. O. 
Published: February 2024

Abstract
Background
Anadromy comprises a successful life-cycle adaptation for salmonids, with marine migration providing improved feeding opportunities and thus improved growth. These rewards are balanced against costs from increased energy expenditure and mortality risk. Anthropogenic-induced environmental changes that reduce benefits and/or increase costs of migration e.g., aquaculture and hydropower, may therefore result in adaptations disfavouring anadromy. We tagged brown trout (Salmo trutta) smolts (N = 175) and veteran migrants (N = 342), from five adjacent riverine populations located in Sognefjorden, the longest Norwegian fjord-system supporting anadromous brown trout populations (209 km). Over four years, 138 acoustic telemetry receivers were deployed to track migrations of tagged individuals from freshwater and throughout Sognefjorden. Detected movements were used to fit migration models and multi-state mark-recapture models of survival and movement for each life-stage. Seaward migration distance was modelled to examine the fitness consequences from alternate migration strategies, with these models used to simulate the extent of fjord-use by individuals and accompanying growth, fecundity and survival consequences. We compared these findings with mark-recapture data collected prior to aquaculture and hydropower development.

Results
The telemetry data revealed that the outermost-fjord region was utilised by all populations albeit by few individuals. However, historical recaptures were located at a greater distance from the river mouth (87.7 ± 70.3 km), when compared to maximum migration distances of present-day counterparts (58.6 ± 54.9 km). River of origin influenced observed migratory behaviour and differential survival was estimated for each population and life-stage. The simulations based on telemetry-data models revealed a 30% and 23% difference in survival among populations for smolts and veteran migrants, respectively. At the individual-level, a long-distance migration strategy was rewarded with enhanced fecundity. However, the main contribution to population-level fecundity was overwhelmingly derived from middle-distance migrants, due to higher mortality rates and limited numbers of long-distant migrants.

Conclusions
We conclude that present-day anadromy is precarious, but potential risk varies considerably between life-stages and populations, even within a single fjord system. Our findings suggest that selection for extended migration is under pressure, we therefore stress the importance of monitoring and management actions to secure genetic variation pertinent to preserve fitness gains of anadromy.
Detecting the effects of opencast mining on ecosystem services value in arid and semi-arid areas based on time-series remote sensing images and Google Earth Engine (GEE)
Authors: Wu Qinyu , Yang Liya , Mi Jiaxin 
Published: February 2024

AbstractEcosystem Services Value (ESV) are the various beneficial functions and products that natural ecosystems provide to humans, and are important indicators for evaluating ecosystem conditions and human well-being. Opencast mining is one of the human activities that severely damage the surface environment, but its long-term impact on ecosystem services lacks systematic assessment. This study takes the Ordos opencast mining area as an example, and calculates the value of ESV from 1990 to 2020 based on the Google Earth Engine platform. Mann-Kendall Tau-b with Sen’s Method (Sen + mk test) and Joinpoint regression model were used to analyzes its spatiotemporal variation characteristics. Further revealed the impacts of opencast mining on ESV as well as the trend of ESV changes. The results show that: (1) The dynamic ESV levels in the study area fluctuated considerably from 1990 to 2020 with an overall decreasing trend of 89.45%. (2) Among nine types ecosystem services, most of them were significantly different (p < 0.001) between mining areas and control areas, with biodiversity protection (BP), climate regulation (CR), gas regulation (GR), soil formation and retention (SFR), water supply (WS) and waste treatment (WT) showed a significant decrease between 1990 and 2020. (3) In the past 30 years, the ESV of the study area showed an overall improvement trend, where the improved area accounted for 48.45% of the total area of the study area. However, the degraded area also accounted for 21.28, and 17.19% of the area belonged to severe degradation. With 67% of the significantly degraded areas distributed within mining concessions. (4) The trend of ESV changes in the mining impact areas and the control area showed significant differences. The ESV of the control area increased continuously, with an average annual percentage change (AAPC) of 0.7(95%CI:0.50 ~ 0.9, P < 0.001) from 1990 to 2020; while the ESV of the mining impact areas first stabilized and then decreased significantly, with an AAPC of − 0.2(95%CI:− 0.3 ~ − 0.1,P < 0.001) from 1990 to 2020. This study provides scientific support for formulating ecosystem management, restoration plans, and payment for ecosystem service policies, which is conducive to achieving regional sustainable development and improving human well-being.
Risk factors of multidrug-resistant organisms neonatal sepsis in Surabaya tertiary referral hospital: a single-center study
Authors: Miranda Stefani , Harahap Aminuddin , Husada Dominicus , Faramarisa Fara Nayo 
Published: February 2024

AbstractBackgroundBacterial organisms causing neonatal sepsis have developed increased resistance to commonly used antibiotics. Antimicrobial resistance is a major global health problem. The spread of Multidrug-Resistant Organisms (MDROs) is associated with higher morbidity and mortality rates. This study aimed to determine the risk factors for developing MDRO neonatal sepsis in the Neonatal Intensive Care Unit (NICU), dr. Ramelan Navy Central Hospital, in 2020–2022.MethodsA cross-sectional study was performed on 113 eligible neonates. Patients whose blood cultures were positive for bacterial growth and diagnosed with sepsis were selected as the study sample. Univariate and multivariate analysis with multiple logistic regression were performed to find the associated risk factors for developing multidrug-resistant organism neonatal sepsis. Ap-value of < 0.05 was considered significant.ResultsMultidrug-resistant organisms were the predominant aetiology of neonatal sepsis (91/113, 80.5%). The significant risk factors for developing MDRO neonatal sepsis were lower birth weight (OR: 1.607, 95% CI: 1.003 − 2.576,p-value: 0.049), history of premature rupture of the membrane (ProM) ≥ 18 (OR: 3.333, 95% CI: 2.047 − 5.428,p-value < 0.001), meconium-stained amniotic fluid (OR: 2.37, 95% CI: 1.512 − 3.717,p-value < 0.001), longer hospital stays (OR: 5.067, 95% CI: 2.912 − 8.815,p-value < 0.001), lower Apgar scores (OR: 2.25, 95% CI: 1.442 − 3.512,p-value < 0.001), and the use of respiratory support devices, such as invasive ventilation (OR: 2.687, 95% CI: 1.514 − 4.771,p-value < 0.001), and non-invasive ventilation (OR: 2, 95% CI: 1.097 − 3.645,p-value: 0.024).ConclusionsOur study determined various risk factors for multidrug-resistance organism neonatal sepsis and underscored the need to improve infection control practices to reduce the existing burden of drug-resistant sepsis. Low-birth-weight, a maternal history of premature rupture of the membrane lasting more than 18 hours, meconium-stained amniotic fluid, longer hospital stays, a low Apgar score, and the use of ventilators were the risk factors for developing drug-resistant neonatal sepsis.
Prevalence of computer vision syndrome during the COVID-19 pandemic: a systematic review and meta-analysis
Authors: León-Figueroa Darwin A. , Barboza Joshuan J. , Siddiq Abdelmonem , Sah Ranjit , Valladares-Garrido Mario J. , Adhikari Suraj , Aguirre-Milachay Edwin , Sah Sanjit , Rodriguez-Morales Alfonso J. 
Published: February 2024

Abstract
Background
Computer vision syndrome has become a significant public health problem, especially in developing countries. Therefore, this study aims to identify the prevalence of computer vision syndrome during the COVID-19 pandemic.

Methods
A systematic review and meta-analysis of the literature was conducted using the databases PubMed, Scopus, Web of Science, and Embase up to February 22, 2023, using the search terms "Computer Vision Syndrome" and "COVID-19". Three authors independently performed study selection, quality assessment, and data extraction, and the Joanna Briggs Institute Meta-Analysis of Statistics Assessment and Review Instrument was used to evaluate study quality. Heterogeneity was assessed using the statistical test I2, and the R version 4.2.3 program was used for statistical analysis.

Results
A total of 192 studies were retrieved, of which 18 were included in the final meta-analysis. The total sample included 10,337 participants from 12 countries. The combined prevalence of computer vision syndrome was 74% (95% CI: 66, 81). Subgroup analysis based on country revealed a higher prevalence of computer vision syndrome in Pakistan (99%, 95% CI: 97, 100) and a lower prevalence in Turkey (48%, 95% CI: 44, 52). In addition, subgroup analysis based on study subjects showed a prevalence of 82% (95% CI: 74, 89) for computer vision syndrome in non-students and 70% (95% CI: 60, 80) among students.

Conclusion
According to the study, 74% of the participants experienced computer vision syndrome during the COVID-19 pandemic. Given this finding, it is essential to implement preventive and therapeutic measures to reduce the risk of developing computer vision syndrome and improve the quality of life of those affected.

Trial registration
The protocol for this systematic review and meta-analysis was registered in the international registry of systematic reviews, the International Prospective Register of Systematic Reviews (PROSPERO), with registration number CRD42022345965.
Functional disability and its associated factors among community- dweller older adults living in Gondar Town, Ethiopia: a community-based cross-sectional study
Authors: Takele Mihret Dejen , Eriku Getachew Azeze , Merawie Destaw Marie , Zinabu Fiseha Sefiwu , Fentanew Molla , Belay Gashaw Jember , Kibret Alemu Kassaw 
Published: February 2024

AbstractBackgroundFunctional disability is an emerging public health concern that has an impact on the health and quality of life of older adults. If functional disability recognized early, it will be possible to support them to live independently. Although functional disability is extensively researched in developed countries; studies are scarce in Sub-Saharan Africa, particularly Ethiopia. Therefore, this study aims to assess the prevalence and associated factors of functional disability in activities of daily living among older adults in Gondar town, Ethiopia.MethodsA community-based cross-sectional study was conducted from April to June 2022. Multistage sampling techniques were used to recruit 607 older adults aged 60 years and older. A pre-tested interview-administered questionnaire was used to assess functional disability in basic activities of daily living and instrumental activities of daily living using the Katz Index and Lawton scale, respectively. Bivariate and multivariable logistic regression models were employed. The findings of the study were presented by descriptive statistics and an adjusted odds ratio with 95% CI was used to determine statistical significance.ResultsThe prevalence of functional disability in basic activities of daily living and instrumental activities of daily living among older adults was 34.5% and 54.4, respectively. Age 80 and older [AOR = 2.41, CI (1.41–4.10)], low-income status [AOR = 2.58, CI (1.50–4.46)], multimorbidity [AOR = 2.97, CI (1.92–4.60)], depression [AOR = 2.97, CI (1.63–5.40)], and low level of physical activity [AOR = 3.31, CI (2.11–5.17)] were associated with basic activities of daily living. Age 80 and older (AOR = 3.11, CI = 1.94-5.00), multimorbidity [AOR = 3.06, CI (2.10–4.46)], and depression [AOR = 3.52, CI (2.10–4.46)] were associated with instrumental activities of daily living.Conclusion and recommendationsOur study finding revealed that functional disability affects a large number of older adult residents. The age group of 80 years and older, low-income status, a low level of physical activity, multimorbidity, and depression were associated with basic and instrumental activities of daily living. Therefore, health interventions designed to increase older adults’ level of physical activity, management of multimorbidity, and depression, more care for elders 80 years and older, and supporting older adults financially for health insurance coverage could be an important strategy to reduce functional disability among older adults.