bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surgical Treatment of Periodontal Intrabony Defects With Calcium Sulfate Implant and Barrier Versus Collagen Barrier or Open Flap Debridement Alone: A 12‐Month Randomized Controlled Clinical Trial
Authors: Paolantonio Michele , Perinetti Giuseppe , Dolci Marco , Perfetti Giorgio , Tetè Stefano , Sammartino Gilberto , Femminella Beatrice , Graziani Filippo 
Published: October 2008

Background: This randomized controlled clinical trial was designed to compare the clinical outcomes of guided tissue regeneration with calcium sulfate graft and membrane (CS) versus guided tissue regeneration with collagen membrane (CM) or open flap debridement (OFD) only in terms of clinical attachment gain in periodontal intrabony defects.Methods: Fifty‐one systemically healthy, non‐smoking subjects affected by moderate to severe chronic periodontitis were recruited. The subjects had one deep intrabony defect with a probing depth (PD) ≥6 mm and were randomly divided into three equal groups (17 subjects per group). Subjects were surgically treated with OFD (OFD group), OFD with CS (CS group), or OFD and CM (CM group). One year after surgical treatment, a complete clinical examination and a surgical reentry were performed. The pre‐ and post‐therapy clinical parameters, including PD, clinical attachment level (CAL), gingival recession (GR), and intrasurgical parameters (defect bone level [DBL]), were compared.Results: After 1 year, the clinical and intrasurgical parameters showed statistically significant changes from baseline within each group for all of the evaluated parameters (PD and CAL, P <0.001; GR and DBL, P <0.05). Differences (PD, CAL, and DBL, P <0.001; GR, P <0.05) were also seen across the three groups. The CM and CS groups had significantly smaller PD, CAL, and DBL values than subjects treated with only OFD. Groups treated with regenerative techniques had a significantly greater PD reduction and CAL and DBL gain compared to the OFD group. No significant differences were seen between CM and CS. Conversely, the CM group showed a significantly greater GR increase compared to OFD and CS.Conclusions: Both regenerative treatments produced additional clinical benefits over OFD alone. Moreover, the use of CS may minimize post‐surgical recession.
Difference Between Selected and Obtained Shade for Metal-ceramic Crown Systems
Authors: Omar H. , Atta O. , El-Mowafy O. 
Published: October 2008

Clinical Relevance
Veneered electroformed crowns and In-Ceram alumina crowns made with CEREC 3D produced shade-matching that was significantly better than that obtained with conventional porcelain-fused-to-metal crowns.
Long-term Survival of Cerec Restorations: A 10-year Study
Authors: Zimmer S. , Göhlich O. , Rüttermann S. , Lang H. , Raab W. H-M. , Barthel C. R. 
Published: October 2008

Clinical Relevance
Class I and II CAD-CAM ceramic restorations can be considered durable alternatives to direct and laboratory-fabricated restorations.
Response of Human Dental Pulp Capped with MTA and Calcium Hydroxide Powder
Authors: Accorinte M. L. R. , Loguercio A. D. , Reis A. , Carneiro E. , Grande R. H. M. , Murata S. S. , Holland R. 
Published: October 2008

Clinical Relevance
Calcium hydroxide powder and MTA healed the pulp exposures comparably. However, calcium hydroxide powder showed a tendency towards faster dentin bridge formation.
Effect of Double-application or the Application of a Hydrophobic Layer for Improved Efficacy of One-step Self-etch Systems in Enamel and Dentin
Authors: Albuquerque M. , Pegoraro M. , Mattei G. , Reis A. , Loguercio A. D. 
Published: October 2008

Clinical Relevance
The double-application and placement of a hydrophobic resin coat can improve the performance (μTBS) of one-step self-etch systems to tooth substrates, mainly in dentin.
The Efficacy of Three Different In-office Bleaching Systems and Their Effect on Enamel Microhardness
Authors: Polydorou O. , Hellwig E. , Hahn P. 
Published: October 2008

Clinical Relevance
Light activation does not seem to increase the efficacy of the bleaching agents tested. After the bleaching procedure, color stability and enamel dehydration are supposed to be two very important parameters in order to evaluate the efficacy of bleaching systems.
Effect of Cyclic Loading on Marginal Adaptation and Bond Strength in Direct vs Indirect Class II MO Composite Restorations
Authors: Aggarwal V. , Logani A. , Jain V. , Shah N. 
Published: October 2008

Clinical Relevance
Indirect composite restorations have better marginal adaptation than direct composite restorations, and cyclic loading has a more deteriorating effect on the marginal adaptation and microtensile bond strength of direct composite restorations than indirect composite restorations.
Antiangiogenic therapy using bevacizumab in recurrent high-grade glioma: impact on local control and patient survival
Authors: Narayana Ashwatha , Kelly Patrick , Golfinos John , Parker Erik , Johnson Glyn , Knopp Edmond , Zagzag David , Fischer Ingeborg , Raza Shahzad , Medabalmi Praveen , Eagan Patricia , Gruber Michael L. 
Published: October 2008

Object
Antiangiogenic agents have recently shown impressive radiological responses in high-grade glioma. However, it is not clear if the responses are related to vascular changes or due to antitumoral effects. The authors report the mature results of a clinical study of bevacizumab-based treatment of recurrent high-grade gliomas.

Methods
Sixty-one patients with recurrent high-grade gliomas received treatment with bevacizumab at 10 mg/ kg every 2 weeks for 4 doses in an 8-week cycle along with either irinotecan or carboplatin. The choice of concomitant chemotherapeutic agent was based on the number of recurrences and prior chemotherapy.

Results
At a median follow-up of 7.5 months (range 1–19 months), 50 (82%) of 61 patients relapsed and 42 patients (70%) died of the disease. The median number of administered bevacizumab cycles was 2 (range 1–7 cycles). The median progression-free survival (PFS) and overall survival (OS) were 5 (95% confidence interval [CI] 2.3–7.7) and 9 (95% CI 7.6–10.4) months, respectively, as calculated from the initiation of the bevacizumab-based therapy. Radiologically demonstrated responses following therapy were noted in 73.6% of cases. Neither the choice of chemotherapeutic agent nor the performance of a resection prior to therapy had an impact on patient survival. Although the predominant pattern of relapse was local, 15 patients (30%) had diffuse disease.

Conclusions
Antiangiogenic therapy using bevacizumab appears to improve survival in patients with recurrent high-grade glioma. A possible change in the invasiveness of the tumor following therapy is worrisome and must be closely monitored.
Novel vasodilatory effect of intracisternal injection of magnesium sulfate solution on spastic cerebral arteries in the canine two-hemorrhage model of subarachnoid hemorrhage
Authors: Mori Kentaro , Miyazaki Masahiro , Hara Yasukazu , Aiko Yasuhisa , Yamamoto Takuji , Nakao Yasuaki 
Published: October 2008

Object
The extracellular Mg++ has a vasodilatory effect on the cerebral artery. The present study investigated the effect of intracisternal injection of MgSO4 solution on cerebral vasospasm in a canine model of subarachnoid hemorrhage (SAH).

Methods
Subarachnoid hemorrhage was induced in 10 beagles using the two-hemorrhage model. Angiography of the vertebrobasilar artery was performed on Day 1 (baseline values before SAH) and on Day 7 (during cerebral vasospasm after induced SAH) before and after intracisternal injection of 0.5 ml/kg of 15 mmol/L MgSO4 solution into the cerebellomedullary cistern.

Results
The cerebrospinal fluid Mg++ concentration was significantly increased to 3.15 ± 1.14 mEq/L after intracisternal injection from the preinjection value (1.45 ± 0.09 mEq/L; p < 0.01). The diameters of the basilar artery, vertebral artery, and superior cerebellar artery on Day 7 were significantly decreased to 58.0 ± 10.9%, 71.0 ± 10.1%, and 60.9 ± 13.8%, respectively, of their baseline diameters on Day 1 (p < 0.01). After intracisternal injection of MgSO4, these diameters significantly increased to 73.8 ± 14.3%, 83.0 ± 14.8%, and 74.1 ± 13.5%, respectively (p < 0.01).

Conclusions
Intracisternal injection of MgSO4 solution causes significant dilation of spastic cerebral arteries in the canine two-hemorrhage model of SAH.
Interhemispheric transcallosal subchoroidal fornix-sparing craniotomy for total resection of colloid cysts of the third ventricle
Authors: Shapiro Scott , Rodgers Richard , Shah Mitesh , Fulkerson Daniel , Campbell Robert L. 
Published: October 2008

Object
Endoscopic surgery has been reported to be more cost-effective and safer than open craniotomy for resection of colloid cysts, despite a 5–10% conversion rate to craniotomy, a 5% recurrence rate, a 5–10% ventricular shunting rate, a 5–10% epilepsy rate, and a 3–4 day hospital stay. In 1985, the authors developed a interhemispheric, transcallosal, subchoroidal, fornix-sparing approach that allowed safe total resection of the colloid cyst and that appeared to be superior to the endoscopic approach. The long-term results are analyzed and compared with findings in the literature.

Methods
Fifty-seven consecutive colloid cysts were totally removed via a 3 ×3–in paramedian craniotomy flap and a microscopic interhemispheric, transcallosal, subchoroidal approach sparing the ipsilateral fornix. The length of the callosotomy was 1.5–2 cm in all patients. The mean follow-up duration was 12 years (range 2–22 years). A retrospective analysis comparing the authors' results with those reported in the endoscopic literature was performed.

Results
All patients had 1-year postoperative imaging studies (CT or MR imaging) documenting gross-total resection with no deaths, infection, hemiparesis, seizures, or disconnection syndrome. One surgery was complicated by bilateral subdural hematomas, which were successfully treated. There has been a zero recurrence rate. Three patients required a permanent ventriculoperitoneal shunt (including 2 who required emergency ventriculostomy before surgery). The mean hospital stay was 4.8 days (range 2–24 days). There was 1 patient with permanent short-term memory loss who presented with a herniation syndrome requiring emergency ventriculostomy.

Conclusions
The interhemispheric, transcallosal, subchoroidal, fornix-sparing approach to gross-total resection of colloid cysts is safe and led to a zero recurrence rate with no permanent neurological sequelae including epilepsy, and these results are superior to any reported results with endoscopy.
External decompressive craniectomy including resection of temporal muscle and fascia in malignant hemispheric infarction
Authors: Park Jaechan , Kim Ealmaan , Kim Gyoung-Ju , Hur Yun-Kyung , Guthikonda Murali 
Published: October 2008

Decompressive craniectomy procedures are used for malignant hemispheric infarctions. However, the temporal muscle and fascia are significant limiting factors for external herniation of an edematous brain. Therefore, the authors performed a decompressive craniectomy and expansive duraplasty combined with resection of the temporal muscle and fascia for 15 patients with a malignant hemispheric infarction.
The volume of the maximum external herniation that was measured on the basis of a CT volumetry study ranged from 130 to 300 ml (mean ± standard deviation, 200 ± 64 ml) on postoperative Day 3.2 ± 1.5 (range 2–5 days postoperatively). The mean value represented a 2-fold volume expansion in comparison with the conventional decompressive craniectomy, and the greater the external herniation obtained by external decompression, the smaller the midline brain shift after surgery. The mortality rate, favorable outcomes (modified Rankin Scale Scores 1–3), and unfavorable outcomes were 20, 60, and 20%, respectively, and the masticatory function was only minimally affected. Furthermore, a cranioplasty involving reconstruction of the temporal muscle defect performed using a MEDPOR implant resulted in good cosmetic outcomes with no temporal hollow.
Resection of the temporal muscle in a decompressive craniectomy was shown to provide greater decompression and better clinical outcomes for malignant hemispheric infarctions at an acceptable cost of minimal masticatory dysfunction and cosmetic disfigurement.
Significant reduction in stereotactic and functional neurosurgical hardware infection after local neomycin/polymyxin application
Authors: Miller Jonathan P. , Acar Feridun , Burchiel Kim J. 
Published: October 2008

Object
Hardware infection is a common occurrence after the implantation of neurostimulation and intrathecal drug delivery devices. The authors investigated whether the application of a neomycin/polymyxin solution directly into the surgical wound decreases the incidence of perioperative infection.

Methods
Data from all stereotactic and functional hardware procedures performed at the Oregon Health & Science University over a 5-year period were reviewed. All patients received systemic antibiotic prophylaxis. For the last 18 months of the 5-year period, wounds were additionally injected with a solution consisting of 40 mg neomycin and 200,000 U polymyxin B sulfate diluted in 10 ml normal saline. The primary outcome measure was infection of the hardware requiring explantation.

Results
Six hundred fourteen patients underwent hardware implantation. Among 455 patients receiving only intravenous antibiotics, the infection rate was 5.7%. Only 2 (1.2%) of 159 patients receiving both intravenous and local antibiotics had an infection. The wounds in both of these patients were compromised postoperatively: 1 patient had entered a swimming pool, and the other had undergone a general surgery procedure that exposed the hardware. If these patients are excluded from analysis, the effective infection rate using a combined intravenous and local antibiotic prophylaxis is 0%. There were no complications due to toxicity.

Conclusions
The combination of local neomycin/polymyxin with systemic antibiotic therapy can lead to a significantly lower rate of postoperative infection than when systemic antibiotics are used alone.
Synthesis of α‐Carbolines Starting from 2,3‐Dichloropyridines and Substituted Anilines
Authors: Hostyn Steven , Van Baelen Gitte , Lemière Guy L. F. , Maes Bert U. W. 
Published: October 2008

Abstract9H‐α‐Carbolines have been prepared via consecutive intermolecular Buchwald–Hartwig reaction and Pd‐catalyzed intramolecular direct arylation from commercially available 2,3‐dichloropyridines and substituted anilines. The combination of a high reaction temperature (180 °C) and the use of DBU were found to be crucial for the intramolecular direct arylation reactions of the 3‐chloro‐N‐phenylpyridin‐2‐amines as no reaction was observed at 120 °C and 180 °C using different inorganic and other organic bases. On the other hand, nitrogen‐methylated pyridine analogues of these substrates {N‐[3‐chloro‐1‐methylpyridin‐2(1H)‐ylidene]anilines} do undergo ring closure at 120 °C, with K3PO4 as base, affording the respective 1‐methyl‐1H‐α‐carbolines in good yields.
Palladium‐Catalyzed Direct C‐4 Arylation of 2,5‐Disubstituted Furans with Aryl Bromides
Authors: Gottumukkala Aditya L. , Doucet Henri 
Published: October 2008

AbstractA simple and atom‐economic procedure for the selective C‐4 arylation of 2,5‐disubstituted furans via CH bond activation using electron‐deficient aryl bromides is reported. Only 0.5 mol% of the commercially available dimeric (allene)palladium chloride, [Pd(C3H5)Cl]2, was employed as catalyst. This environmentally attractive procedure has been found to be tolerant to a variety of functional groups on the aryl bromide such as carbonyl, nitrile, nitro, fluoro, ester or trifluoromethyl.
Highly Enantioselective Friedel–Crafts Reaction of 4,7‐Dihydroindoles with β,γ‐Unsaturated α‐Keto Esters by Chiral Brønsted Acids
Authors: Zeng Mi , Kang Qiang , He Qing‐Li , You Shu‐Li 
Published: October 2008

AbstractA highly efficient Friedel–Crafts reaction of 4,7‐dihydroindoles with β,γ‐unsaturated α‐keto esters by a chiral N‐triflyl phosphoramide was realized, affording the 2‐substituted 4,7‐dihydroindoles with up to 98% ee for a wide range of substrates. The Friedel–Crafts alkylation together with a subsequent oxidation of the product with p‐benzoquinone led to a 2‐alkylated indole derivative in 98% ee.
Proteins in Mesoporous Silicates
Authors: Hudson Sarah , Cooney Jakki , Magner Edmond 
Published: October 2008

AbstractMesoporous silicates (MPS) have an ordered pore structure with dimensions comparable to many biological molecules. They have been extensively explored as supports for proteins and enzymes in biocatalytic applications. Since their initial discovery, novel syntheses methods have led to precise control over pore size and structure, particle size, chemical composition, and stability, thus allowing the adsorption of a wide variety of biological macromolecules, such as heme proteins, lipases, antibody fragments, and proteases, into their structures. This Review discusses the application of ordered, large‐pore, functionalized mesoporous silicates to immobilize proteins for biocatalysis.
Stereoselective Glycal Fluorophosphorylation: Synthesis of ADP‐2‐fluoroheptose, an Inhibitor of the LPS Biosynthesis
Authors: Dohi Hirofumi , Périon Régis , Durka Maxime , Bosco Michael , Roué Yvain , Moreau François , Grizot Sylvestre , Ducruix Arnaud , Escaich Sonia , Vincent Stéphane P. 
Published: October 2008

AbstractHeptosides are found in important bacterial glycolipids such as lipopolysaccharide (LPS), the biosynthesis of which is targeted for the development of novel antibacterial agents. This work describes the synthesis of a fluorinated analogue of ADP‐L‐glycero‐β‐D‐manno‐heptopyranose, the donor substrate of the heptosyl transferase WaaC, which catalyzes the incorporation of this carbohydrate into LPS. Synthetically, the key step for the preparation of ADP‐2F‐heptose is the simultaneous and stereoselective installation of both the fluorine atom at C‐2 and the phosphoryl group at C‐1 through a selectfluor‐mediated (selectfluor=1‐chloromethyl‐4‐fluorodiazoniabicyclo[2.2.2]octane bis(triflate)) electrophilic addition/nucleophilic substitution involving a heptosylglycal. Therefore, we detail in this article 1) the stereoselective preparation of the key intermediates heptosylglycals, 2) the development of a new fluorophosphorylation procedure allowing an excellent β‐gluco stereoselectivity with “all‐equatorial” glycals, 3) the synthesis of the target ADP‐2F‐heptose, and 4) some comments on the contacts observed between the fluorine atom of the final molecule and the protein in the crystallographic structure of heptosyltransferase WaaC.
Stereochemical Assignment and First Synthesis of the Core of Miharamycin Antibiotics
Authors: Marcelo Filipa , Jiménez‐Barbero Jesús , Marrot Jérôme , Rauter Amélia P. , Sinaÿ Pierre , Blériot Yves 
Published: October 2008

AbstractThe relative configuration at C‐6′ of nucleoside antibiotic miharamycin A has been elucidated by NMR spectroscopy and proved to be S. The total synthesis of miharamycin B has also been investigated, which has led to the unprecedented construction of its core. The bicyclic sugar moiety has been elaborated by means of a SmI2‐based keto–alkyne coupling. Elongation of its C‐6 position towards a bicyclic sugar amino acid and conversion into a suitable glycosyl donor enabled efficient N‐glycosylation with 2‐aminopurine to take place to afford the nucleosidic part of miharamycin B. Final peptide coupling with arginine afforded the skeleton of miharamycin B. Unfortunately, attempts to deprotect this scaffold failed to afford the complex nucleoside antibiotic.
ChemInform Abstract: Impurity Effects on Small Pd Clusters: A Relativistic Density Functional Study of Pd4X, X: H, C, O.
Authors: Genest Alexander , Krueger Sven , Roesch Notker 
Published: October 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Can Undoped Calcium Tetraborides Exist? An Answer from the Comparison of Its Density Functional Theory Electronic Structure with that of Rare‐Earth Metal Tetraboride.
Authors: Yahia Mouna Ben , Reckeweg Olaf , Gautier Regis , Bauer Joseph , Schleid Thomas , Halet Jean‐Francois , Saillard Jean‐Yves 
Published: October 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The New Pentaborate Na3SrB5O10.
Authors: Wu Li , Roth Georg , Sparta Karine , Chen Xiaolong 
Published: October 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A New Type of Mixed Anionic Framework in Microporous Rubidium Copper Vanadyl(V) Phosphate, Rb2Cu(VO2)2(PO4)2.
Authors: Yakubovich Olga V. , Steele Ian M. , Dimitrova Olga V. 
Published: October 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Ammonia Borane Destabilized by Lithium Hydride: An Advanced On‐Board Hydrogen Storage Material.
Authors: Kang Xiangdong , Fang Zhanzhao , Kong Lingyan , Cheng Huiming , Yao Xiangdong , Lu Gaoqing , Wang Ping 
Published: October 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Highly Crystalline Inverse Opal Transition Metal Oxides via a Combined Assembly of Soft and Hard Chemistries.
Authors: Orilall M. Christopher , Abrams Neal M. , Lee Jinwoo , DiSalvo Francis J. , Wiesner Ulrich 
Published: October 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: High‐Pressure Synthesis of Superconducting Molybdenum Nitride δ‐MoN by in situ Nitridation.
Authors: Inumaru Kei , Nishikawa Takanori , Nakamura Kazuharu , Yamanaka Shoji 
Published: October 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Spin‐Ladder Iron Oxide: Sr3Fe2O5.
Authors: Kageyama Hiroshi , et al. et al. 
Published: October 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.