bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cancer in young adults between the ages of 15 and 34 years in greater Bombay
Authors: Jussawalla D. J. , Yeole B. B. 
Published: February 2007

AbstractAn attempt has been made in this study to examine the nature and magnitude of the cancer problem in young adults between the ages of 15 and 34 years living in Greater Bombay. The morbidity data utilised for this exercise were obtained from the Bombay Cancer Registry and the mortality analysis was made from the death records maintained by the Bombay Municipal Corporation. In Greater Bombay, the ratio of cancer incidence in this specific group as compared with the total incidence of the disease in the general population was very high in comparison with the Western incidence. The site most commonly affected by cancer in young adults seems to be the lymphatic and haematopoietic tissues in males and breast and cervix in females. The morbidity and mortality rates of the disease in the general population and in children reveal an overall male preponderance, but the situation is found to be totally reversed in young adults. Then again, the incidence as well as the mortality rates appear to decrease with advancing age in children, but in young adults the incidence increases with age. Leukaemia is the most commonly encountered malignancy in the young adult male, followed by cancers of the testes and bones, Hodgkin's disease, and cancers of the brain and connective tissues, in descending order of frequency. In females, breast cancer has the highest incidence followed by cancer of the cervix, leukaemia, and cancers of the ovary and thyroid. When the various registers are ranked according to age‐adjusted incidence rates, the figures for Greater Bombay are seen to be at the lowest levels in both sexes.
Tumor location and drug targeting using a monoclonal antibody (anti‐SSEA‐1) and antigen‐binding fragments
Authors: Ballou Byron , Reiland Jean M. , Levine Geoffrey , Taylor Rodney J. , Shen Wei‐Chiang , Ryser Hughes J.‐P. , Solter Davor , Hakala Thomas R. 
Published: February 2007

AbstractBoth murine and heterotransplanted human nonseminomatous germ‐cell tumors have been successfully located by external scintigraphy using radioiodinated anti‐SSEA‐1, a monoclonal IgM, and its pepsin‐derived antigen‐binding fragment, F(ab′)2μ. Antibody localization in the tumor is mainly due to antigenic specificity, rather than to nonspecific trapping, and depends strongly on the amount of time after injection. The antibody has been used for drug targeting in vitro and in vivo.
Aortic rupture in manual dissection of the esophagus: A rare complication during palliative esophagectomy performed on account of radiated esophageal cancer. A pathologic‐anatomic view
Authors: Sons Hans U. 
Published: February 2007

AbstractThe report concerns the rare complication of a rupture of the aorta thoracica descendens during a palliative esophagectomy without thoracotomy performed on account of radiated carcinoma of the esophagus. The pathologic‐anatomic findings are discussed and the literature is indicated.
Demonstration of cutaneous doxorubicin extravasation by rhodamine‐filtered fluorescence microscopy
Authors: Duray Paul Harrison , Cuono Charles B. , Madri Joseph A. 
Published: February 2007

AbstractAccidental extravasation of the widely used antineoplastic anthracycline doxorubicin (adriamycin) is capable of causing serious and on‐going skin and soft tissue necrosis leading to loss of limb function. The only effective cure has been the complete surgical excision of drug‐contaminated tissue. Surgical excisions preparatory to skin grafting have often underestimated the extent of drug infiltration into tissue. Using an experimental technique utilizing the drug's natural property of red fluorescence, we were able to effect complete surgical excision by rhodamine fluorescence microscopy in frozen sections of resected skin.
Carcinoma of eccrine sweat gland: Experience with chemotherapy, autopsy findings in a patient with metastatic eccrine carcinoma, and a review of the literature
Authors: Morris Don M. , Sanusi I. Daniel , Lanehart William H. 
Published: February 2007

AbstractCarcinoma of sweat glands is a very rare neoplasm of dermal appendages that is difficult to diagnose clinically and histologically. It has a potential for rapid growth and metastasis. Carcinoma of eccrine sweat glands, also known as eccrine carcinoma, is a distinct histologic subtype of sweat gland carcinoma. We report our autopsy findings and experience with chemotherapy in a patient with metastatic eccrine carcinoma. The pertinent literature and histologic classification of eccrine carcinomas are reviewed.
Extraskeletal Ewing's sarcoma: First case report in Greece
Authors: Vartholomeos A. A. , Destouni E. T. , Salem N. , Destouni H. , Valassis K. , Tselepis G. 
Published: February 2007

AbstractThe first case of soft tissue Ewing's sarcoma in Greece is presented. The tumour was a circumscribed large mass at the right calf, was radically excised and histologically proved to be small cell malignant neoplasm, performing the characteristic structural and cytological pattern of Ewing's sarcoma. Systematic clinical and radiological examination was negative. Operation was followed by local radiotherapy and systematic chemotherapy and the patient remains disease‐free and clinically in perfect health eight months after the operation. The case is presented with special reference to its histological appearance and its treatment.
Tumor differentiation and histological type in human breast cancer
Authors: Bell C. D. , Stadler J. , Waizbard E. , Chaitchik S. , Greif F. 
Published: February 2007

AbstractBiopsies from 61 women with breast cancer were assessed for various histological features. These results were statistically analyzed for associations of gross tumor size, patient age, stage of disease, tumor hormone receptor status, with accepted systems of nuclear and histological grading for differentiation.Tumors with highly differentiated grading had smaller cell nuclei, stromal elastasis, intraduct carcinoma and tubular formations. Poorly differentiated tumors had large vesicular cell nuclei and increased mitotic indices. Gross tumor size was also linked with stromal elastosis, intraduct carcinoma, a specific pattern of stromal infiltration, and mitotic index. No relationship could be found between any of the above features and the patients clinical statuses or their tumors' hormone receptivities. The existence of two distinct histological patterns of breast carcinoma is proposed; the patterns may either represent stages in the development of the tumor or different biological types.
Common duct stricture associated with hepatic artery infusion of FUDR
Authors: Laughlin Edward H. 
Published: February 2007

AbstractA case report is presented giving the first detailed description of a benign common duct stricture occurring in a patient receiving hepatic artery infusion of FUDR for metastatic colon cancer. It is postulated that the stricture results from a combination of drug toxicity, and hypoxemia of the duct, with the lesion occurring more often than is recognized. A guide is given for the evaluation of the FUDR‐infused patient with suspected nonmalignant duct stricture, and for the methods of alleviating extrahe‐patic blockage in these individuals.
Plantar verrucous carcinoma (epithelioma cuniculatum): Case report with review of the literature
Authors: Kathuria Satinder , Rieker John , Jablokow Victor R. , Van Den Broek Hans 
Published: February 2007

AbstractVerrucous carcinoma is a rare highly keratinizing variant of squamous cell carcinoma that is a slow‐growing, locally aggressive, and rarely metastasizing tumor. It may involve various body sites including oral, genital, and plantar areas. The tumor has a characteristic gross appearance with multiple sinuses opening on the surface and may present a difficult diagnostic problem. Multiple biopsies and close clinical correlaction are frequently required before a definite diagnosis is possible. The differential diagnosis is especially difficult if only fragments or superficial portions of the lesion are submitted for histological evaluation.Reviewing surgical material from our institution from 1976 to 1983, we located four cases of verrucous carcinoma of the foot. These four cases were diagnosed on the bases of clinical, gross, and microscopic appearances. One of the cases had bilateral lesions. One of the cases is described with review of the literature.
Prognoses and surgical treatment of patients with stage I melanomas of the skin: A retrospective analysis of 211 patients
Authors: Welvaart K. , Hermans J. , Zwaveling A. , Ruiter D. J. 
Published: February 2007

AbstractFrom 1960 to 1982, a total number of 216 patients with Stage I melanoma underwent local excision as the single treatment. Life‐table analysis was performed on 211 evaluable patients to investigate the prognostic value of several factors on survival as well as disease‐free survival. The influence of sex, age, localization of the tumor, and margin of the excision on prognosis was not statistically significant. The Clark level and Breslow thickness were important factors to predict the prognosis. Local recurrence occurred in only one patient; in most cases tumor growth close to the original site of excision indicates early manifestation of hematogenic spread. Lymph node metastases developed in 31 patients; ten of them remained free of disease after node dissection. Six patients died from hematogenic metastases without nodal involvement. Tumors with thickness < 1.5 mm have excellent prognosis regardless of the location of the melanoma or the margin of the excision. With increasing thickness of the tumor, prognosis is proportionally worse. By performing wide excisions the final outcome can not be improved.
Hepatocellular carcinoma presenting as bone pain
Authors: Robinson Dan L. , Davaiah K. A. , Lawton Richard L. 
Published: February 2007

AbstractHepatocellular carcinoma is an uncommon malignancy in the western world, and its presentation as symptomatic skeletal metastasis is rare. The following describes a patient whose initial complaint was arm pain that was subsequently found to be due to metastatic hepatocellular carcinoma. A review of the literature describing skeletal involvement by hepatocellular carcinoma is included.
Pure squamous cell carcinoma of the breast
Authors: Lafreniere Rene , Moskowitz Lee B. , Ketcham Alfred S. 
Published: February 2007

AbstractPathological curiosities have always fascinated the surgical community, and management of breast cancer by the physician has, at times, revealed such rarities. A recent case of squamous cell carcinoma in a clear fluid breast cyst has prompted a review of our experience with this rare pathology, and allowed us to make the following statements: We propose that squamous cell carcinoma of the breast arises from ductal metaplasia. When the T.N.M. system is applied to the squamous cell lesion, the apparent poor prognosis that it is believed to carry may not be so apparent. If no other primaries are identified after extensive metastatic work‐up, surgical therapy consisting of total mastectomy with complete axillary dissection, is very effective in local control of tumor progress. Nodal status will indicate the need for additional modalities of therapy.
Congenital hemangiopericytoma
Authors: Chen Karl T. K. , Kassel Stephen H. , Medrano Victor A. 
Published: February 2007

AbstractThe clinicopathologic features of a case of congenital hemangiopericytoma are described and compared with those of previously reported cases. Features connotative of malignancy in adult or childhood hemangioperi‐cytomas, such as high mitotic activity, increased cellularity, and tissue necrosis or hemorrhage, are frequently observed in congenital tumors. However, the congenital tumors are biologically benign. Spontaneous tumor regression observed in our case further suggests a conservative approach in the treatment of congenital hemangiopericytomas.
Combined 5‐fluorouracil (5‐FU) and radiation therapy following resection of locally advanced gastric carcinoma
Authors: Gez E. , Sulkes A. , Yablonsky‐Peretz T. , Weshler Z. 
Published: February 2007

AbstractTwenty‐five patients with locally advanced but resectable adenocarcinoma of the stomach were given concomitant postoperative radiotherapy to the tumor bed and chemotherapy with 5‐Fluorouracil (5‐FU). Twenty‐two of the patients had regional lymph node involvement and seven had residual tumor in the surgical margins. Radiotherapy was delivered to a total dose of 5,000 rads in 7 weeks with a two‐week split. 5‐FU was given daily the first 3 days of each treatment period and was then continued weekly for a minimum of 1 year. At a median follow‐up time of 19 months, 11 patients have relapsed, two locally and nine distally, and all have died. Thirteen patients remain alive, all but one disease‐free, for a median of 21 months from diagnosis. One additional patient died of unrelated causes, free of tumor. The actuarial median survival for the whole group stands at 33 months with a projected 5‐year survival of 40%. Treatment has been well tolerated.
Eosinopmlic granuloma of the stomach
Authors: Van Rensburg L. C. J. , Keet A. D. , Adams G. 
Published: February 2007

AbstractTwo patients with eosinophilic granuloma of the stomach are discussed. The first patient had extensive and time‐consuming investigations before the diagnosis was confirmed after surgery, while the second patient's presentation corresponded so closely to the first that a correct preoperative diagnosis was entertained with a minimum of investigations and delay. The barium‐meal examinations in both patients were very typical of the condition, but the endoscopy findings and biopsy histology reports were noncontributory. Neither of the patients had a history of allergy or eosin‐ophilia. The lesions were localized to the distal part of the stomach and the resected specimens were microscopically typical of eosinophilic granuloma of the stomach.
Prophylactic oophorectomy in premenopausal women with stage II breast carcinoma
Authors: Kashtan H. , Birkenfeld S. , Rath P. , Brenner H. J. , Krispin M. 
Published: February 2007

AbstractProphylactic oophorectomy, as an additional treatment for stage II breast cancer, is controversial. In a retrospective study, a group of 37 premenopausal women with stage II infiltrating duct carcinoma and one to three positive axillary lymph node involvement after modified radical mastectomy and bilateral oophorectomy were compared to a matched group of 34 women treated by modified radical mastectomy only. Prophylactic oophorectomy prolonged the disease free interval significantly as compared to the control group. However, it did not prolong survival. This raises the question whether the prolongation of survival achieved by late oophorectomy in women with advanced breast cancer is preferable to an improvement in quality of life resulting from longer disease free intervals.
Patient's and doctor's delay in carcinoma of the colon and rectum
Authors: Graffner Hans , Olsson Sven‐Åke 
Published: February 2007

AbstractDespite sophisticated diagnostic equipment and modern surgical therapy, the prognosis for patients with colorectal carcinoma has not improved during the last few decades. One of the factors, possibly contributing to the prognosis, is the time between the patient's visit to the doctor and the final therapy. In order to estimate patients' and doctors' delay and to investigate the factors which may influence the time of delay, a prospective study was designed including 50 patients with carcinoma of the rectum or the sigmoid colon and 50 patients with colonic carcinoma above this level. All patients were interviewed by a doctor using a standard questionnaire, and initial symptoms, duration of symptoms, and type of clinical examination leading to diagnosis were recorded. The results show that 16% of the patients in the recto/sigmoid group suffered from patient's delay as opposed to 20% in the group of patients with carcinoma above 25 cm from the anal verge. Doctor's delay was found in 27% of all cases, being evenly distributed in the two groups. The reason for doctor's delay was usually the doctor's neglecting to perform rectosigmoidoscopy or rectal palpation, and in some cases a false‐negative X‐ray. No significant correlation was found between tumor stage and doctor's or patient's delay.
Additional malignant neoplasms in patients with breast carcinoma
Authors: Lee Yeu‐Tsu Margaret 
Published: February 2007

AbstractDuring a follow‐up of 665 patients with carcinoma of the breast age 40 years or older, 46 developed a second primary carcinoma of the opposite breast and 30 developed a nonmammary malignancy (median FU = 6 yrs). Comparing our number of observed cases with the number of expected cases (calculated from the female age‐specific incidence rate of the data of the Surveillance, Epidemiology and End Results (SEER) and from the actual cumulative person‐years of follow‐up), our patients with breast cancer did not have higher probability of developing additional nonmammary malignancy, but did have over five times the chance of developing a second breast cancer as other females to have any such cancer. Comparing the distribution of specific sites of our nonmammary second cancer with that reported by the SEER's study, the proportions of patients with colorectal, lung cancer, and lymphoma were similar. But we did see relatively more carcinomas of the uterine cervix, ovary, vulva, sarcoma, and stomach/duodenum, and fewer carcinoma of the endometrium. These differences could be explained by our small series, patient characteristics, and selected referral pattern.
Peritoneal lavage as an aid in the surgical management of neutropenic colitis
Authors: Geer Deborah A. , Lee Yeu‐Tsu Margaret , Barcia Peter J. 
Published: February 2007

AbstractNeutropenic colitis is a severe, often devastating complication of acute leukemia. The diagnosis can be difficult as the symptoms are often those of the leukemia itself or of the therapy being rendered. These anemic, thrombocytopenic, and severely immunosuppressed patients present great operative risks. Distinction between the surgical and nonsurgical abdomen can be a challenge for even the most experienced surgeon. Peritoneal lavage may serve as a means to help in this differentiation.
Tumor measurement in the nude mouse
Authors: Euhus David M. , Hudd Charles , Laregina Marie C. , Johnson Frank E. 
Published: February 2007

AbstractIn this study, the pitfalls of tumor measurement in the nude mouse were evaluated. Regarding intermethod variation, diameters of subcutaneous tumors in nude mice were expressed as length, area, and volume; tumor weights were also recorded. These measurements were all compared to a reference standard: water displacement volume. Estimates of area and volume derived from caliper measurements correlated well with water displacement volume (r = 0.97 and 0.98, respectively). At necropsy, tumor weight was the most consistent and reproducible reflection of tumor volume (r = 1.0000). Regarding interobserver variation, mean absolute difference among volumes determined by several investigators who measured the same tumors in living animals was determined. This averaged 15% of the mean calculated volume. Regarding intraobserver variation, observers measured four separate masses in nude mice eight times each. The observers were prevented from realizing that the same animals were being repeatedly evaluated. Volumes were compared in order to quantify the average variation that occurs when a single investigator repeatedly measures the same mass. When large masses were measured, this error was 7%; when small masses were measured, the error was 27%. Recommendations are made for future work employing tumor measurement.
Development of a metastatic human colon cancer xenograft model in the nude mouse
Authors: Lundy Joel , Greiner John W. , Colcher D. 
Published: February 2007

AbstractThe objective of our experimental protocols was to develop a metastatic model for a human colon carcinoma xenograft in congenitally athymic nude mice. This model would be useful in evaluating the efficacy of radiolabeled monoclonal antibodies for detection and treatment of regional and distant metastases. The LS‐174T human colon carcinoma line was used to establish primary subcutaneous tumors in nude mice. Mice were killed at varying time intervals to establish the incidence of spontaneous metastases. Only lung micrometastases were observed during the 2‐month observation period. To increase the metastatic rate, the site of primary implanation was varied and/or surgical manipulations were performed. Excision of small primary tumors resulted in a low incidence of local recurrence and no distant metastases. However, with excision of large primary tumors, a high local recurrence rate was noted and over 30% of mice had gross metastases. Mice bearing hind footpad tumors underwent excision when tumors were at least 1 cm in size. There were no local recurrences, but by 8 weeks over 40% had large pulmonary metastases. The LS‐174T tumor was also established as a primary implant in the spleen from which 10 to 15% of the mice developed liver or lung metastases. The LS‐174T tumor can metastasize in the nude mice and the latter two models may prove very useful in imaging and therapy studies.
Cholecystitis secondary to infusion chemotherapy
Authors: Pietrafitta Joseph J. , Anderson Bernhard G. , O'Brien Michael J. , Deckers Peter J. 
Published: February 2007

AbstractThis report centers on a patient with metastatic colorectal cancer who developed acute and chronic cholecystitis secondary to the infusion of FUDR (fluoro‐deoxyuridine) into the hepatic artery. This was documented by sonography, cholescintigraphy, and, ultimately, pathologically on the surgically removed specimen. Undoubtedly, with increasing cumulative treatment days made possible through technological advances in delivery systems, this complication will be seen more frequently. Prophylactic removal of the gallbladder, at the time of pump placement, which does not significantly prolong the operative time nor increase the operative mortality, should be performed to prevent this complication from occurring.
Liposarcoma arising within a cystosarcoma phyllodes
Authors: Jimenez Jorge F. , Gloster Elizabeth S. , Perrot Linda J. , Mollitt Daniel L. , Gollady E. Stevers 
Published: February 2007

AbstractA liposarcoma arising within a cytosarcoma phyllodes in a 17‐year‐old black female was treated by total mastectomy without the need of radiation and/or chemotherapy. The patient is alive and well with no evidence of recurrence or metastasis at 20 months recent follow‐up. The clinocopathological features of malignant cystosarcoma phyllodes‐liposarcoma are discussed.