bluuebunny/crossref_metadata_2025_split huggingface dataset:
Performance Issues of Dietetic Interns:A Dietetic Educator's Perspective
Authors: Lordly Daphne 
Published: May 2007

Purpose: Dietetic internships provide practical experience leading, in most cases, to the attainment of entry-level dietetic competence. Problematic intern performance issues were examined, as were how educators resolve these issues and the supports they require to manage them.Methods: A survey was electronically distributed to all Dietitians of Canada internship/university course directors (n=57). The response rate was 40% (n=23).Results: Annually, 61% of internships involve challenging performance issues related to intern knowledge, skills, attitude, and behaviour. These issues manifest themselves individually or in combination as an intern's inability to apply/demonstrate appropriate knowledge/skill, a view/approach to the profession that is not in keeping with the organizational view, an attitude that is in conflict with program values, a negative response to feedback, an inability to relate to others, work habits that are in conflict with program values, and personal attributes that detract from the ability to meet program expectations. Educators respond to these issues by modifying their communications, the learning environment, and the program.Conclusions: Educators’ strategies could be enhanced through consultation with other educators, mentor training, and the development of formal procedures.
Cover Picture: Encapsulation of Water‐Immiscible Solvents in Polyglutamate/ Polyelectrolyte Nanocontainers (Adv. Funct. Mater. 8/2007)
Authors: Teng X. , Shchukin D. G. , Möhwald H. 
Published: May 2007

AbstractA novel approach for encapsulation of hydrophobic materials into hydrophilic multifunctional shells is based on combining ultrasonic techniques and layer‐by‐layer protocols. Polyglutamate/polyelectrolyte nanocontainers of 600 nm size loaded with hydrophobic tetraphenylporphin are fabricated in work reported by Dmitri Shchukin and co‐workers on p. 1273. The hydrophobic core of the nanocontainers can encapsulate a huge variety of water‐insoluble drugs and the outer hydrophilic polyelectrolyte shell has controlled permeability and multifunctionality.A novel approach for encapsulation of hydrophobic materials into a hydrophilic multifunctional shell is presented, based on combining an ultrasonic technique and a layer‐by‐layer protocol. Polyglutamate/polyethyleneimine (PEI)/polyacrylic acid (PAA) and polyglutamate/PEI/PAA/silver nanocontainers loaded with a hydrophobic dye, 5,10,15,20‐tetraphenylporphin, dissolved in toluene, are fabricated. Uniform, stable, and monodisperse polyglutamate/PEI/PAA nanocontainers of about 600 nm are obtained. The hydrophobic core of the nanocontainers might contain a huge variety of water‐insoluble drugs and the outer polyelectrolyte shell may provide controlled permeability and desired multifunctionality. Confocal fluorescence microscopy and scanning electron microscopy are employed for the characterization of the resulting nanocontainers. Using sodium dodecyl sulfate as surfactant, the amount of nanocontainers, their monodispersity, and stability can be increased dramatically.
Hydroxyurea therapy for management of secondary erythrocytosis in cyanotic congenital heart disease
Authors: Reiss Ulrike M. , Bensimhon Pamela , Zimmerman Sherri A. , Ware Russell E. 
Published: May 2007

AbstractSecondary erythrocytosis in cyanotic congenital heart disease (CCHD) causes substantial morbidity because of complications of hyperviscosity, including stroke and chronic end organ damage. Phlebotomy provides temporary improvement but leads to iron deficiency and can actually increase blood viscosity. We describe the successful use of hydroxyurea (hydroxycarbamide) in four patients with uncorrected CCHD and symptomatic secondary erythrocytosis. In all patients, hydroxyurea improved symptoms of hyperviscosity. Substantial decreases in the red blood cell (RBC) count were observed, along with increases in the mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH), leading to only modest declines in the circulating hemoglobin concentration. Two patients experienced transient mild myelosuppression, which promptly resolved with dose reduction of hydroxyurea. Hydroyxurea provides a novel and useful therapeutic approach to reduce hyperviscosity from secondary erythrocytosis in patients with CCHD, while preserving oxygen carrying capacity and avoiding iron depletion by phlebotomy. Am. J. Hematol., 2007. © 2007 Wiley‐Liss, Inc.
Normal hematopoietic function and multiple bone marrow clonal abnormalities in a patient with acute myeloid leukemia after two mismatched stem‐cell transplants with graft failure and autologous reconstitution
Authors: Ostronoff Fabiana , Bueso‐Ramos Carlos , Cortes Jorge , Giralt Sergio 
Published: May 2007

AbstractA 13‐year‐old male with primary refractory acute myelogenous leukemia (AML‐M0), underwent two mismatched stem cell transplantations (SCT) and experienced graft failure after both procedures. Of interest, his peripheral blood cell counts are normal 7 years after his first SCT, his bone marrow is morphologically normal, however, cytogenetic analysis reveals multiple recurring cytogenetic abnormalities. This is the third case of chromosomal instability with morphological normal marrow and peripheral blood to be reported, these rare cases suggest that hematopoietic stem cells must have compensating mechanisms that allow normal function despite extensive chromosomal damage, supporting the notion that normal marrow function is possible even with extensive chromosomal damage. Am. J. Hematol., 2007. © 2007 Wiley‐Liss, Inc.
The role of autoantibody‐producing plasma cells in immune thrombocytopenic purpura refractory to rituximab
Authors: Kuwana M. , Iki S. , Urabe A. 
Published: May 2007

AbstractRituximab is becoming popular as a treatment for immune thrombocytopenic purpura (ITP). We report here a patient with ITP, who initially responded to rituximab, but later became refractory. In this patient, the appearance of plasma cells producing anti‐platelet autoantibodies is likely to be one of the mechanisms for rituximab resistance. Am. J. Hematol., 2007. © 2007 Wiley‐Liss, Inc.
Treatment of acquired severe aplastic anemia with antilymphocyte globulin, cyclosporin A, methyprednisolone, and granulocyte colony‐stimulating factor
Authors: Dinçol Günçağ , Aktan Melih , Diz‐Küçükkaya Reyhan , Yavuz Selim , Nalçacı Meliha , Öztürk Şükrü , Palanduz Şükrü , Doğan Öner , Ağan Mehmet 
Published: May 2007

AbstractFifty‐six adult patients with newly diagnosed acquired severe aplastic anemia (SAA) received horse antilymphocyte globulin (ALG), cyclosporin A (CyA), methylprednisolone (Mpred), granulocyte colony‐stimulating factor (G‐CSF) as first‐line therapy. The median age was 34 (range, 17–72) and median neutrophil count 0.280 × 109/L. Trilineage hematologic recovery (at a median interval of 105 days from treatment) was seen in 46 patients (37 complete, 9 partial) after one (n = 38) or two (n = 8) courses of ALG. Cytogenetic abnormalities were observed in three unresponders, clonal hematologic disease in three complete responders, and relapse of marrow aplasia in four complete responders. Median follow up for surviving patients was 1,668 days (range, 237–4,012). The actuarial survival at 5 years was 82%, falling to 77.1% at 7 years and was stationary at 7 and 8 years. Survival was not influenced by the neutrophil count (72% vs. 87%, for neutrophils less than vs. greater than 0.2 × 109/L; P = 0.54). Immunosuppressive treatment of SAA with the 4‐drug combination appears to be effective. The significant prognostic effect of an enduring increase of the white blood cell (WBC) count during G‐CSF treatment may suggest complete and partial response to therapy. In nonresponders, the WBC count either did not change or elevated values gradually returned to nearly their initial levels while the patients were still under G‐CSF treatment. In patients not responsive to treatment but living under CyA and G‐CSF, the possibility of developing cytogenetic abnormalities does not seem to be low, despite the absence of findings attributable to manifest myelodysplastic syndrome. Am. J. Hematol., 2007. © 2007 Wiley‐Liss, Inc.
Hepatic veno‐occlusive disease after tranexamic acid administration in patients undergoing allogeneic hematopoietic stem cell transplantation
Authors: Mori Takehiko , Aisa Yoshinobu , Shimizu Takayuki , Yamazaki Rie , Mihara Ai , Yajima Tomoharu , Hibi Toshifumi , Ikeda Yasuo , Okamoto Shinichiro 
Published: May 2007

AbstractTranexamic acid is one of the widely used antifibrinolytic agents. In spite of its effective inhibitory activity against plasminogen, thromboembolic adverse events caused by tranexamic acid are rare. We encountered three recipients of allogeneic hematopoietic stem cell transplantation (HSCT) who developed hepatic veno‐occlusive disease (VOD) shortly after the administration of tranexamic acid. Hepatic VOD was resolved completely in all patients with the discontinuation of the drug, and with supportive measures with or without intravenous tissue plasminogen activator administration. These findings suggest that administration of tranexamic acid could be one of the possible risk factors for developing hepatic VOD in HSCT recipients. Am. J. Hematol., 2007. © 2007 Wiley‐Liss, Inc.
Colobomatous macrophthalmia with microcornea syndrome maps to the 2p23‐p16 region
Authors: Elcioglu Nursel H. , Akin Burcu , Toker Ebru , Elcioglu Mustafa , Kaya Ali , Tuncali Timur , Wollnik Bernd , Hornby Stella , Akarsu Nurten A. 
Published: May 2007

AbstractColobomatous macrophthalmia with microcornea syndrome (OMIM 602499) is a rare, autosomal dominant malformation characterized by microcornea, uveal coloboma, axial enlargement of the globe, and myopia. Using what is currently the largest described pedigree and candidate localization approach, we first excluded the candidate genes PAX2, PAX3, PAX6, and PAX9. Subsequently, the chromosome 14q24 region containing the CHX10, SIX1, and SIX4 genes were also excluded. Positive LOD scores were obtained with the DNA markers selected from the 2p23‐p16 region. A maximum pairwise LOD score of 3.61 (Θ = 0) was noted with the DNA marker D2S1788. Haplotype analysis positioned the locus between DNA markers D2S2263 and D2S1352 within a 22 Mb physical interval. This region contains major candidate genes, such as SIX2, SIX3, and CYP1B1; however, mutation analysis did not identify a causative mutation in these genes. Macrophthalmia, colobomatous, with microcornea (MACOM) is proposed as the gene symbol for this malformation linked to 2p23‐p16. © 2007 Wiley‐Liss, Inc.
Detection of a de novo interstitial 2q microdeletion by CGH microarray analysis in a patient with limb malformations, microcephaly and mental retardation
Authors: Svensson Annika M. , Curry Cynthia J. , South Sarah T. , Whitby Heidi , Maxwell Teresa M. , Aston Emily , Fisher Jamie , Carmack C.E. , Scheffer Alicia , Abu‐Shamsieh Aimee , Brothman Arthur R. 
Published: May 2007

AbstractWe describe the cytogenetic diagnosis using BAC‐ and oligonucleotide microarrays of a 16‐year‐old Laotian‐American female, who first presented at 2½ years of age with microcephaly, developmental retardation, and skeletal abnormalities of the upper limb including mild syndactyly of the second and third and the third and fourth fingers, short middle phalanges and clinodactyly of the fifth digit at the distal interphalangel joint on both hands, and symphalangism of the metacarpal‐phalangeal joints of the second and fifth digits bilaterally. Her lower limbs displayed symphalangism of the metatarsal‐phalangeal joint of the second, third, and fourth digits on both feet, with fusion of the middle and distal phalanges of the second and fifth digits and hallux valgus bilaterally. G‐banded chromosomal study at age 4 was normal. However, comparative genomic hybridization at age 15 with the Spectral Genomics 1 Mb Hu BAC array platform indicated a microdeletion involving two BAC clones, RP11‐451F14 → RP11‐12N7 at 2q31.1. The maximal deletion on initial analysis comprised the HOXD cluster, which is implicated in limb development. Florescence in situ hybridization (FISH) using the RP11‐451F14 probe confirmed the deletion. Both parents were negative for the deletion. Additional FISH using BAC RP11‐387A1, covering the HOXD cluster, limited the maximal deletion to approximately 2.518 Mb, and excluded involvement of the HOXD cluster. The Agilent 44K and 244K platforms demonstrated a deletion of approximately 2,011,000 bp, which did not include the HOXD cluster. The malformations in our patient may be caused by deletion of a regulatory element far upstream of the HOXD cluster. © 2007 Wiley‐Liss, Inc.
A newly recognized craniosynostosis syndrome with features of Aarskog–Scott and Teebi syndromes
Authors: Hoffman Jodi D. , Irons Mira , Schwartz Charles E. , Medne Livija , Zackai Elaine H. 
Published: May 2007

AbstractWe present two unrelated boys with craniosynostosis and similar facial features including hypertelorism, down‐slanted palpebral fissures, ptosis, broad mouth with a thin upper lip, and preauricular pits. Both patients had short, broad first digits as well as short, broad hands. Both also had respiratory difficulties and umbilical abnormalities. Although, many of these features are seen in Aarskog–Scott and in Teebi hypertelorism syndromes, both children had craniosynostosis, which has not been previously reported in either syndrome. We propose that these children may have a previously unreported syndrome consistent with X‐linked inheritance, although an autosomal dominant mode of transmission cannot be excluded. © 2007 Wiley‐Liss, Inc.
Interstitial deletion of 6q without phenotypic effect
Authors: Hansson Kerstin , Szuhai Karoly , Knijnenburg Jeroen , van Haeringen Arie , de Pater Joke 
Published: May 2007

AbstractCytogenetically detectable euchromatic deletions without phenotypic consequences are rarely encountered. We report on a 34‐year‐old woman with normal intelligence referred for karyotyping because of recurrent abortions. With the exception of a bicuspid aortic valve without hemodynamic consequences, which is a common minor anomaly in the general population, no dysmorphic features were found on physical examination. Conventional chromosome analysis (GTG‐banding) revealed an interstitial deletion in the long arm of chromosome 6. With array comparative genomic hybridization (array‐CGH) the size of the deletion was estimated to be between 9.9 and 11.6 Mb and the refined karyotype was 46,XX,del(6)(q22.31q23.1). © 2007 Wiley‐Liss, Inc.
Report of a child with a complete de novo 17p duplication localized to the terminal region of the long arm of chromosome 17
Authors: Paskulin Giorgio A. , Zen Paulo R.G. , Rosa Rafael F.M. , Manique Rosana C. , Cotter Philip D. 
Published: May 2007

AbstractWe report the second case of a child with trisomy of the entire short arm of chromosome 17 secondary to a de novo duplication. Trisomy 17p in this patient resulted from a duplication, localized to the distal region of the long arm of the same chromosome, an abnormality not previously described. This cytogenetic abnormality was confirmed using whole chromosome paint, subtelomeric and Smith‐Magenis probes by fluorescence in situ hybridization (FISH) analysis. The child presented with phenotypic features previously described in trisomy 17p, including some specific facial dysmorphia, microcephaly, growth retardation, hypotonia, short webbed neck, congenital heart defect, minor abnormalities of the hands, agenesis of the corpus callosum and abnormalities of the iris. Iris alterations and defects involving the left side of heart and the aorta also may represent truly clinical hallmarks of this cytogenetic abnormality. In conclusion, this cytogenetic anomaly seems to represent a severe malformation entity with a poor prognosis and a recognizable clinical pattern that justifies the use of the term “17p trisomy syndrome” suggested previously by other authors. © 2007 Wiley‐Liss, Inc.
Influence of the copolymer architecture and composition on the response and mechanical properties of pH‐sensitive fibers
Authors: Sahoo Anasuya , Jassal Manjeet , Agrawal Ashwini K. 
Published: May 2007

AbstractA series of copolymers based on acrylonitrile (AN) and acrylic acid (AA) with varying architecture and composition were synthesized using free radical polymerization. The distribution of monomers in the copolymer chains could be successfully controlled by regulating the addition of more reactive monomer (AA). Copolymers having nearly random distribution of comonomer moieties to block type distribution with different composition (10–50 mol % AA) were synthesized to investigate the effect of polymer architecture and composition on pH response and mechanical properties of resultant structures. These copolymers were solution spun from dimethylformamide‐water system, drawn in coagulation bath, and annealed at 120°C for 2 h to make pH‐sensitive fibers which were structurally stable without the need of chemical crosslinking. The fibers from block copolymers showed significantly better tensile strength (34.3 MPa), higher retractive forces (0.26 MPa), and enhanced pH response (swelling 3890%) in comparison with fibers from random copolymer (13.55 MPa, 0.058 MPa, and 1723%, respectively). The tensile strength and retractive forces could be further improved to a value of 72 MPa and 0.36 MPa, respectively, by changing the composition of the block copolymer while retaining the swelling percentage similar to the random copolymer mentioned above. It is proposed that on processing to fibers, the block copolymers could form a segregated domain structure with separate domains of AA and AN, where AN domains were responsible for high structural integrity by providing connectivity among polymer chains, while AA domains showed improved response to changing pH of the environment. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci 2007
Synthesis of tri(hydroxyphenyl)methane using polyaniline‐p‐toluenesulfonic acid salt
Authors: Palaniappan S. , Sudhakar P. 
Published: May 2007

AbstractSynthesis of tri(hydroxyphenyl)methane and tri(hydroxyphenyl)butane were achieved using polyaniline‐p‐toluenesulfonic acid salt as polymeric solid acid catalyst. This method provides several advantages such as easy preparation of the catalyst, its stability, recovery and easy work‐up procedure. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci 2007
Which is the compromise option? Information format and task format as determinants
Authors: Chang Chung‐Chau , Liu Hsin‐Hsien 
Published: May 2007

AbstractWhen consumers must make a decision but are uncertain of their preferences, they often select a compromise choice. Early studies emphasized the relational properties of choice alternatives and indicated that the middle option, whose attribute values fall between the values of other alternatives, is always the compromise option. More recent studies have suggested that when consumers rate two attributes with the same metrics, the attribute–balance choice whose two attributes have equal ratings, might represent the compromise choice. We propose that the different characteristics of the middle and attribute–balance options—which may be compatible with certain determinants such as information and task formats—might be more salient and affect the relative attractiveness of each option. The results of three experiments confirmed this prediction: the middle option was more attractive in list‐by‐attributes and rejecting conditions, whereas the attribute–balance option was more attractive in list‐by‐alternatives and choosing conditions. Copyright © 2007 John Wiley & Sons, Ltd.
Cooperation of plants and microorganisms: Getting closer to the genetic construction of sustainable agro‐systems
Authors: Tikhonovich Igor A. , Provorov Nikolai A. 
Published: May 2007

AbstractThe molecular research into two types of beneficial plant‐microbe symbioses is reviewed: nutritional (with N2‐fixing bacteria or mycorrhizal fungi) and defensive (with endo‐ and epiphytic microbes suppressing pathogens and phytophagans). These symbioses are based on the signaling interactions that result in the development of novel tissue/cellular structures and of extended metabolic capacities in the partners, which greatly improve the adaptive potential of plants due to a decrease in their sensitivity to biotic and abiotic stresses. The molecular, genetic and ecological knowledge on plant‐microbe interactions provides a strategy for the organization of sustainable crop production based on substituting the agrochemicals (mineral fertilizers, pesticides) by microbial inoculants. An improvement of plant‐microbe symbioses should involve the coordinated modifications in the partners' genotypes resulting in highly complementary combinations. These modifications should be based on the broad utilization of genetic resources from natural symbiotic systems aimed at: (i) increased competitiveness of the introduced (effective) with respect to local (ineffective) microbial strains, and (ii) overcoming the limiting steps in the metabolic machineries of the symbiotic systems.
Gray, black, and blue: the state of research and intervention for intimate partner abuse among elders
Authors: Desmarais Sarah L , Reeves Kim A 
Published: May 2007

AbstractThough not as common as in younger populations, intimate partner abuse (IPA) among elders is a significant and often overlooked problem. In this article, we focus on problems for research and intervention. We begin with a brief review of the phenomena of elder abuse and IPA, highlighting problems resulting from definitional issues and inconsistencies in research methodology. The balance of the paper comprises a discussion of problems for intervention. Drawing from the IPA and elder abuse literatures, risk factors unique to IPA among elders are presented, and limitations of existing screening and risk assessment instruments for use within this context are identified. The focus then shifts to legal considerations when working with elders who have experienced or perpetrated IPA. Our goals are to synthesize the elder abuse and IPA literatures, identify limitations within both, and to reflect upon the state of knowledge regarding IPA among elders. Copyright © 2007 John Wiley & Sons, Ltd.
Decision‐making capacity in elderly, terminally ill patients with cancer
Authors: Sorger Brooke Myers , Rosenfeld Barry , Pessin Hayley , Timm Anne Kosinski , Cimino James 
Published: May 2007

AbstractDespite the importance and complexity of evaluating decision‐making capacity at the end of life, little research has focused on terminally ill patients' decision‐making ability. The purpose of this study was to explore the decision‐making capacity of elderly, terminally ill patients and the psychological and physical factors that affect decision making. Decision‐making capacity and cognitive abilities were assessed using four measures: the Hopkins Competency Assessment Kit, the Bechara Gambling Task, the Concept Assessment Kit, and the Mini Mental Status Exam. In addition, symptoms of depression, level of physical functioning, and extent of physical symptoms were evaluated in order to identify correlates of decision‐making ability. Two samples were compared: elderly, terminally ill patients with cancer (n = 43) and elderly, physically healthy adults living in supportive community residence (n = 35). Results revealed significantly poorer decision‐making abilities among the terminal ill sample compared with healthy comparisons, but no association between demographic variables (e.g., age, race, or education) or clinical variables (depression or physical symptoms) and decision making. Implications for evaluating decision‐making capacity are addressed. Copyright © 2007 John Wiley & Sons, Ltd.