bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adult daughters' reports of breast cancer risk reduction and early detection advice received from their mothers: an exploratory study
Authors: Sinicrope Pamela S. , Patten Christi A. , Clark Lara P. , Brockman Tabetha A. , Frost Marlene H. , Petersen Larra R. , Vierkant Robert A. , Vachon Celine M. , Fredericksen Zachary S. , Janney Carol A. , Sellers Thomas A. , Cerhan James R. 
Published: July 2008

AbstractObjective: Awareness of cancer family history is dependent upon communication between family members. Communication of this information and related decision‐making could be important factors influencing breast cancer risk reduction and early detection behaviors. Using survey data from 2328 women (mean age 62.5 years) from 372 families enrolled in the Minnesota breast cancer family study, we explored adult daughter's reports of breast cancer risk reduction advice received from their mothers.Methods and results: Approximately 212 (9%) of respondents reported receiving breast cancer risk reduction advice from their mothers and 130 (89%) reported acting upon such advice. Having a mother or first degree relative (FDR) with a history of breast cancer was significantly correlated with following advice to a higher degree as compared with those not having such family history (p=0.003).Most frequently reported types of advice were to have mammograms (36%) and to have clinical breast exams (35%). Using multivariable logistic regression and after accounting for non‐independence of the sample, significant independent correlates of receiving advice included younger age, having an affected mother, and having a higher perceived breast cancer risk. Receiving advice was also correlated with engaging in a higher number of health promoting behaviors and ever having received a mammogram.Conclusions: Our preliminary findings are consistent with social influence theory and suggest that mother–daughter communication about reducing risk, especially among those having a FDR with breast cancer, could be a potential pathway through which breast cancer family history is associated with the adoption of breast cancer screening and risk reduction behaviors. Copyright © 2008 John Wiley & Sons, Ltd.
Disseminated tumor cells in bone marrow following definitive radiotherapy for intermediate or high‐risk prostate cancer
Authors: Berg Arne , Bruland Øyvind S. , Fosså Sophie D. , Nesland Jahn M. , Berner Aasmund , Schirmer Cecilie , Lilleby Wolfgang 
Published: July 2008

AbstractBackgroundThe purpose of this study was to explore the prevalence of disseminated tumor cells (DTCs) in bone marrow (BM) of clinically progression‐free prostate cancer (PC) patients at least 2 years after curatively intended radiotherapy (RT) with or without adjuvant hormone treatment.MethodsAll patients were T1–3N0M0 with intermediate or high risk of progression. Median time from RT to BM sampling was 5 years (2–8). A standardized immunocytochemical method applying the anticytokeratin antibodies AE1/AE3 was used for DTCs detection in 130 patients. Morphological characterization of immunostained cells was performed to exclude false positive cells. The post‐treatment BM was explored in relation to pre‐treatment risk factors, treatment strategy and serum levels of Testosterone and PSA at the time of BM sampling. Longitudinal changes in BM status were studied in a sub‐group of 109 patients who also had donated BM prior to treatment.ResultsPost‐treatment BM‐aspirates were positive for DTCs in 17% of cases without correlation to any of the tested variables. Out of 14 patients who had DTCs in BM prior to treatment, all but one had become post‐treatment negative. Out of 95 patients with pre‐treatment negative BM status, 18 (19%) had become post‐treatment positive.ConclusionsDTCs in BM were found in 17% of clinically progression‐free PC patients following RT. The detection of these cells may provide PSA‐independent prognostic information remaining to be explored by prolonged follow‐up. Prostate 68: 1607–1614, 2008. © 2008 Wiley‐Liss, Inc.
Optimal data collection for correlated mutation analysis
Authors: Ashkenazy Haim , Unger Ron , Kliger Yossef 
Published: July 2008

AbstractThe main objective of correlated mutation analysis (CMA) is to predict intraprotein residue–residue interactions from sequence alone. Despite considerable progress in algorithms and computer capabilities, the performance of CMA methods remains quite low. Here we examine whether, and to what extent, the quality of CMA methods depends on the sequences that are included in the multiple sequence alignment (MSA). The results revealed a strong correlation between the number of homologs in an MSA and CMA prediction strength. Furthermore, many of the current methods include only orthologs in the MSA, we found that it is beneficial to include both orthologs and paralogs in the MSA. Remarkably, even remote homologs contribute to the improved accuracy. Based on our findings we put forward an automated data collection procedure, with a minimal coverage of 50% between the query protein and its orthologs and paralogs. This procedure improves accuracy even in the absence of manual curation. In this era of massive sequencing and exploding sequence data, our results suggest that correlated mutation‐based methods have not reached their inherent performance limitations and that the role of CMA in structural biology is far from being fulfilled. Proteins 2009. © 2008 Wiley‐Liss, Inc.
Structure based mechanism of the Ca2+‐induced release of coelenterazine from the Renilla binding protein
Authors: Stepanyuk Galina A. , Liu Zhi‐Jie , Vysotski Eugene S. , Lee John , Rose John P. , Wang Bi‐Cheng 
Published: July 2008

AbstractThe crystal structure of the Ca2+‐loaded coelenterazine‐binding protein from Renilla muelleri in its apo‐state has been determined at resolution 1.8 Å. Although calcium binding hardly affects the compact scaffold and overall fold of the structure before calcium addition, there are easily discerned shifts in the residues that were interacting with the coelenterazine and a repositioning of helices, to expose a cavity to the external solvent. Altogether these changes offer a straightforward explanation for how following the addition of Ca2+, the coelenterazine could escape and become available for bioluminescence on Renilla luciferase. A docking computation supports the possibility of a luciferase‐binding protein complex. Proteins 2009. © 2008 Wiley‐Liss, Inc.
Stress‐driven transport in ordered porous anodic films
Authors: Houser Jerrod E. , Hebert Kurt R. 
Published: July 2008

AbstractIonic transport in porous anodic alumina (PAA) films during steady‐state growth was simulated, including effects of ionic migration in the electric potential and stress gradients, as well as material flow. The calculated flow patterns display similar characteristics to those revealed by experimental studies. The results indicate that the stress field driving the flow originates from three sources: volume change at the metal–film interface during oxidation, the nonlinear current–electric field relationship governing ionic conduction, and insertion of species at the film–solution interface. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Influence of molecular adsorbates on the structure of electrodeposited nanocrystalline ZnO
Authors: Loewenstein T. , Sann J. , Neumann C. , Meyer B. K. , Schlettwein D. 
Published: July 2008

AbstractPure ZnO or ZnOEosinY with adsorbed EosinY molecules was deposited electrochemically from aqueous zinc salt solutions on (0001)GaN and (0001)ZnO. X‐ray diffraction revealed the deposition of crystalline ZnO in all cases, with almost perfect orientation in the c ‐direction. Shifts in the peak positions observed for ZnOEosinY were explained by a lattice expansion by 3.6% in the c ‐direction caused by the strong influence of the EosinY molecules adsorbed during the growth of ZnO. Scanning electron microscopy (SEM) was used to elucidate the film morphology. Photoluminescence measurements served to determine changes in the electronic structure of these nanocrystalline materials. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Effect of package light transmittance on the vitamin content of milk, part 3: Fortified UHT low‐fat milk
Authors: Saffert Alexander , Pieper Gabriele , Jetten Jan 
Published: July 2008

AbstractThis work is the third and last part of a milk study evaluating the effect of package light transmittance on the vitamin content of milk, in this case on fortified UHT low‐fat milk. The milk was stored under light with an intensity of 700 lux in polyethylene terephthalate (PET) bottles with varying light transmittance to monitor the changes in the vitamin A, B2 and D3 contents over a storage period of 12 weeks at 23°C. Milk packed in pigmented PET bottles with the lowest light transmittance, which was stored in the dark under the same experimental conditions, served as the ‘control’ sample. In clear PET bottles, a reduction of 93% of the initial content was observed for vitamin A and 66% for vitamin D3, while the vitamin B2 content was completely degraded. In all pigmented PET bottles, the vitamin retention was only slightly higher; the losses ranged between 70 and 90% for vitamin A, between 63 and 95% for vitamin B2, and between 35 and 65% for vitamin D3 depending on the pigmentation level. In the dark‐stored ‘control’ sample, a 16% loss could be observed for vitamin A, while the level of vitamins B2 and D3 remained almost stable. Copyright © 2008 John Wiley & Sons, Ltd.
Relevance of organizational capabilities and its dynamics: what to learn from entrants' product portfolios about the determinants of entry timing
Authors: Lee Gwendolyn K. 
Published: July 2008

AbstractThe resource‐based view of the firm suggests that the timing of market entry by a firm depends on its resources and capabilities, but several important questions remain. First, in a high‐velocity market where capabilities change quickly, how does entry timing depend on the capabilities at varying points in time? Second, how much flexibility does a firm have in altering its capabilities to achieve desirable entry timing? To answer these questions, this study sets out to develop a dynamic, refined version of the resource‐based view that parameterizes a firm by its time‐varying capability relevance with respect to a focal market, and makes predictions on entry timing and future growth of capability relevance. The study develops a novel approach that uses the entrants' product portfolios to infer a potential entrant's capability relevance. The results based on a panel of potential entrants show that the initial and current capability relevance each affect entry timing alone, revealing the persistent effect of the initial condition. However, given the knowledge of the current capability relevance, the initial relevance has no effect on entry timing, suggesting that the initial relevance affects entry timing through its influence on the current relevance. Firms that are in an initially unfavorable position can still achieve early entry, provided that they improve their capability relevance over time. Copyright © 2008 John Wiley & Sons, Ltd.
Patterned Layers of a Semiconducting Polymer via Imprinting and Microwave‐Assisted Grafting
Authors: Moran Isaac W. , Jhaveri Sarav B. , Carter Kenneth R. 
Published: July 2008

AbstractEnhancements in both the rate and extent of grafting of poly(9,9′‐n‐dihexyl fluorene) (PDHF) onto flat and nanopatterned crosslinked photopolymer films are described. Reactivity of the surfaces toward grafting via the Yamamoto‐type Ni(0)‐mediated coupling reaction is increased by synthesizing and incorporating 2,7‐dibromo‐9‐fluorenyl methacrylate (DBFM, 2) as a new grafting agent. Varying the concentration of surface‐embedded DBFM is shown to control both overall graft formation and fluorescence with a maximum thickness of up to 30 nm and peak emission at 407 nm for 40 wt% loading. In addition, microwave irradiation is introduced as an effective means to drive graft formation and thus allows fabrication of PDHF‐functionalized surfaces in as little as 30 min. Both forms of improvement are extended to DBFM‐embedded, nanocontact‐molded features ranging in size from 100 µm to 100 nm in width and 60 nm in height. Microwave‐assisted grafting from these patterned surfaces produces fluorescent features as imaged by optical microscopy and a corresponding increase in feature height as measured by atomic force microscopy.
Self‐Assembly of Cerium Oxide Nanostructures in Ice Molds
Authors: Karakoti Ajay S. , Kuchibhatla Satyanarayana V. N. T. , Baer Donald R. , Thevuthasan Suntharampillai , Sayle Dean C. , Seal Sudipta 
Published: July 2008

AbstractThe formation of nanorods, driven by the physicochemical phenomena during the freezing and after the aging of frozen ceria nanoparticle suspensions, is reported. During freezing of a dilute aqueous solution of CeO2 nanocrystals, some nuclei remain in solution while others are trapped inside micro‐ and nanometer voids formed within the growing ice front. Over time (2–3 weeks) the particles trapped within the nanometer‐wide voids in the ice combine by an oriented attachment process to form ceria nanorods. The experimental observations are consistent with molecular dynamics simulations of particle aggregation in constrained environments. These observations suggest a possible strategy for the templated formation of nanostructures through self‐assembly by exploiting natural phenomena, such as voids formed during freezing of water. This research suggests a very simple, green chemical route to guide the formation of one‐ and three‐dimensional self‐assembled nanostructures.
A whole sample toxicity assessment to evaluate the sub‐lethal toxicity of water and sediment elutriates from a lake exposed to diffuse pollution
Authors: Abrantes N. , Pereira R. , de Figueiredo D. R. , Marques C. R. , Pereira M. J. , Gonçalves F. 
Published: July 2008

AbstractThe impact of diffuse pollution in aquatic systems is of great concern due to the difficult to measure and regulate it. As part of an ecological risk assessment (ERA), this study aims to use a whole sample toxicity assessment to evaluate the toxicity of water and sediment from Lake Vela, a lake that has been exposed to diffuse pollution. In this way, standard (algae: Pseudokirchneriella subcapitata; cladoceran: Daphnia magna) and local species (algae: Aphanizomenon flos‐aquae; cladoceran: Daphnia longispina) were exposed to surface water, and sediment elutriates were collected seasonally from two sites at Lake Vela: one near the east bank (ES), surrounded by agricultural lands; and the other near the west bank (WS), surrounded by a forest. The results confirmed the seasonal contamination of both environmental compartments by pesticides, including organochlorine pesticides, and the presence of high concentrations of nutrients. Although both sites were contaminated, higher levels of pesticides and nutrients were detected in ES, particularly in the sediments. Bioassays showed that water samples (100% concentration) collected in summer and autumn significantly affected the growth rate of P. subcapitata, which could be attributed to the presence of pesticides. Likewise, they revealed an apparent toxicity of elutriates for P. subcapitata and for both daphnids, in summer and autumn. In fact, although pesticides were not detected in elutriates, high levels of un‐ionized ammonia were recorded, which is considered highly toxic to aquatic life. By comparing the several species, P. subcapitata was revealed to be the most sensitive one, followed by the daphnids, and then by A. flos‐aquae. Results obtained in this study underlined the importance of whole samples toxicity assessment for characterizing the ecological effects of complex mixtures from diffuse inputs, in the ERA processes. © 2008 Wiley Periodicals, Inc. Environ Toxicol, 2009.
The LNS portable PIXE‐alpha system for the examination of gold preparations in the Salerno 492 code miniatures
Authors: Pappalardo L. , Bicchieri M. , Nardone M. , Pappalardo G. , Romano F. P. , Russo P. A. , Sodo A. 
Published: July 2008

AbstractThe gold preparations of the Salerno 492 code were examined by means of the LNS portable PIXE‐alpha spectrometer. Complementary XRF and micro‐Raman techniques were also used. Quantitative data enable to establish the composition of the various gold preparations. Copyright © 2008 John Wiley & Sons, Ltd.
A XANES study on the structural role of zinc in ancient tile glazes of Portuguese origin
Authors: Veiga J. P. , Figueiredo M. O. 
Published: July 2008

AbstractLead‐rich blue‐and‐white tile glazes (16th to 17th century, Portuguese manufacture) were studied by x‐ray absorption near‐edge spectroscopy (XANES) to assess the speciation and coordination environment of zinc, a fuser metal commonly used along with lead in ancient glazes. Zincite (ZnO) and smithsonite (ZnCO3) were used as model compounds for Zn2+ ions in tetrahedral and octahedral coordinations, respectively and theoretical simulations of Zn 1s XANES spectra were undertaken using the FEFF code based on the full multiple‐scattering approach. Comparison between calculated and actual spectra collected from the glazes showed differences that are discussed in terms of oxygen‐anion linkages within the silica‐rich glassy matrix. Obtained results support the conclusion that zinc assumes a low‐coordination environment, most probably tetrahedral, in the studied ancient tile glazes. Copyright © 2008 John Wiley & Sons, Ltd.
Comparative analysis of the resonant Raman cross sections of pure samples and oxides
Authors: Valentinuzzi María Cecilia , Sánchez Héctor Jorge , Abraham José , Pérez Carlos 
Published: July 2008

AbstractMonochromatic synchrotron radiation was used to study the Raman effect on pure samples of Mn, Fe, and Cu and on oxides such as Mn2O3, Fe2O3, CuO and Cu2O. Energy scannings were carried out for different ranges of energies near the absorption edge of the target element. Theoretical models for the energy distribution of the Raman scattered photons, convoluted with the instrument function, were used to determine the resonant Raman scattering (RRS) cross sections as a function of the incident energy. The results indicate that RRS cross sections for pure samples are similar to those for oxides for the same energy difference from the respective edge, showing that the Raman scattering takes place in the same way in both kinds of samples. Copyright © 2008 John Wiley & Sons, Ltd.
NDT&E techniques and SEM‐EDS for the assessment of cleaning interventions on Pentelic marble surfaces
Authors: Delegou E. T. , Avdelidis N. P. , Karaviti E. , Moropoulou A. 
Published: July 2008

AbstractIn this work, several non‐destructive testing and evaluation (NDT&E) techniques along with scanning electron microscopy with energy dispersive x‐ray spectroscopy (SEM‐EDS) were applied on Pentelic marble surfaces. The investigated Pentelic marble surface disclosed a representative decay pattern that usually develops in polluted urban atmosphere such as the Athens centre. The applied techniques aimed to collate as much as possible evidence about the physico‐chemical and aesthetical characteristics of the examined surfaces before and after the pilot cleaning treatments, in an attempt to configure an effective assessment methodology of cleaning interventions. The applied NDT&E techniques were fibre‐optic microscopy, colourimetry and laser profilometry. The results were encouraging enough to propose the use of these NDT&E techniques along with SEM‐EDS as an everyday assessment tool of cleaning conservation interventions on Pentelic marble. Copyright © 2008 John Wiley & Sons, Ltd.
Heat shock protein 27 expression in the human testis showing normal and abnormal spermatogenesis
Authors: Adly Mohamed A. , Assaf Hanan A. , Hussein Mahmoud Rezk A. 
Published: July 2008

AbstractHeat shock proteins (HSPs) are molecular chaperones involved in protein folding, assembly and transport, and which play critical roles in the regulation of cell growth, survival and differentiation. We set out to test the hypothesis that HSP27 protein is expressed in the human testes and its expression varies with the state of spermatogenesis. HSP27 expression was examined in 30 human testicular biopsy specimens (normal spermatogenesis, maturation arrest and Sertoli cell only syndrome, 10 cases each) using immunofluorescent methods. The biopsies were obtained from patients undergoing investigations for infertility. The seminiferous epithelium of the human testes showing normal spermatogenesis had a cell type‐specific expression of HSP27. HSP27 expression was strong in the cytoplasm of the Sertoli cells, spermatogonia, and Leydig cells. Alternatively, the expression was moderate in the spermatocytes, weak in the spermatids and absent in the spermatozoa. In testes showing maturation arrest, HSP27 expression was strong in the Sertoli cells, weak in the spermatogonia, and spermatocytes. It was absent in the spermatids and Leydig cells. In Sertoli cell only syndrome, HSP27 expression was strong in the Sertoli cells and absent in the Leydig cells. We report for the first time the expression patterns of HSP27 in the human testes and show differential expression during normal spermatogenesis, indicating a possible role in this process. The altered expression of this protein in testes showing abnormal spermatogenesis may be related to the pathogenesis of male infertility.
Cognitive‐behavioral therapy for persistent pain: Does adherence after treatment affect outcome?
Authors: Curran Charlotte , de Williams Amanda C. C. , Potts Henry W.W. 
Published: July 2008

ABSTRACTIt is a tenet of cognitive behavioral treatment of persistent pain problems that ex‐patients should adhere to treatment methods over the longer term, in order to maintain and to extend treatment gains. However, no research has quantified the causal influence of adherence on short‐term outcome in this field. The aims of this study are to assess determinants of adherence to treatment recommendations in several domains, and to examine the extent to which cognitive and behavioral adherence predicts better outcome of cognitive behavioral treatment for persistent pain. Longitudinal data from a sample of 2345 persistent pain patients who attended a multicomponent treatment programme were subjected to structural equation modeling. Adherence emerged as a mediating factor linking post‐treatment and follow‐up treatment outcome, but contributed only 3% unique variance to follow‐up outcomes. Combined end‐of‐treatment outcomes and adherence factors accounted for 72% of the variance in outcome at one‐month follow‐up. Notwithstanding shortcomings in the measurement of adherence, these findings question the emphasis normally given to adherence in the maintenance of behavioral and cognitive change, and clinical implications are discussed.