bluuebunny/crossref_metadata_2025_split huggingface dataset:
Model-based prediction of frost formation inside frozen food packages under temperature fluctuations
Authors: Nakagawa Kyuya , Nakabayashi Maya , Yasunobu Toshiko 
Published: April 2024

Abstract
Frozen storage of food products is widely accepted not only in the industry but also by households. Frost formation during long-term storage is recognized as a phenomenon that causes changes in product characteristics and quality losses. However, quantitative prediction and control of frost formation remains a challenge. In this study, a mathematical model was developed to predict frost formation inside frozen food products (i.e., frozen minced meat packed in a polyvinylidene chloride (PVDC) film) under fluctuating temperature conditions in a domestic refrigerator. The proposed model is based on heat transfer and energy balance equations, and the amount of frost formation is estimated from the heat generated by condensation. The heat transfer coefficients were experimentally obtained and applied to the developed model. The interactions between the amplitude and frequency of temperature fluctuations and the corresponding amount of frost formation were visualized using contour plots. Both the amplitude and frequency were found to increase frost formation. For the range of fluctuations tested (temperature amplitudes of 0.5–2.5 K and cooling rates of 0.0125–0.2 K/min when connected to the compressor), the simulation predicted that the amount of frost in the packages varied up to approximately 4.5 times (0.48–2.18 g/month for packages containing 300 g of minced meat) depending on the different temperature fluctuation settings.
Policy Approaches for Increasing Adolescent HPV Vaccination Coverage: A Systematic Review
Authors: McKeithen Mary Catharine , Gilkey Melissa B. , Kong Wei Yi , Oh N. Loren , Heisler-MacKinnon Jennifer , Carlson Rebecca , James Greeshma , Grabert Brigid K. 
Published: April 2024

CONTEXT
US jurisdictions have enacted a wide range of policies to address low human papillomavirus (HPV) vaccination coverage among adolescents, but it is unclear which policies are effective.

OBJECTIVE
To systematically review the impact of governmental policies on adolescent HPV vaccination coverage.

DATA SOURCES
PubMed, Embase, and Scopus databases.

STUDY SELECTION
Eligible studies, published from 2009 to 2022, evaluated the impact of governmental policies on HPV vaccination coverage among adolescents ages 9 to 18.

DATA EXTRACTION
Two investigators independently extracted data on study sample, study design and quality, policy characteristics, and HPV vaccination outcomes. We summarized findings by policy type: school-entry requirements (SERs), federally-funded policies related to the Vaccines for Children program and Medicaid, educational requirements, and others.

RESULTS
Our search yielded 36 eligible studies. A majority of studies evaluating HPV vaccine SERs found positive associations between SERs and HPV vaccination coverage (8 of 14), particularly for SERs in Rhode Island and Washington, DC. All studies evaluating SERs for other adolescent vaccines observed positive spillover effects for HPV vaccination (7 of 7). Federally-funded policies related to Vaccines for Children and Medicaid were consistently associated with higher HPV vaccination coverage (7 of 9). Relatively few studies found associations between educational requirements and HPV vaccination coverage (2 of 8).

LIMITATIONS
Studies used limited vaccination data sources and non- or quasi-experimental designs. Some studies had no or poorly matched comparison groups.

CONCLUSIONS
Our findings suggest promise for SERs and federally-funded policies, but not educational requirements, for increasing HPV vaccination coverage among adolescents.
Resveratrol modulates the Nrf2/NF-κB pathway and inhibits TSLP-mediated atopic march
Authors: He Quan , Liu Weihua , Chen Zi , Wei Guangfei , Jiang Jingxian , Zhang Liuchao , Zhou Linfu 
Published: April 2024

Background: Resveratrol has been found to have anti-inflammatory and anti-allergic properties. The effects of resveratrol on thymic stromal lymphopoietin (TSLP)-mediated atopic march remain unclear.
Purpose: To explore the potential role of resveratrol in TSLP-mediated atopic march.
Methods: The atopic march mouse model was established by topical application of MC903 (a vitamin D3 analog). Following the treatment with resveratrol, airway resistance in mice was discovered by pulmonary function apparatus, and the number of total cells, neutrophils, and eosinophils in bronchoalveolar lavage fluid was counted. The histopathological features of pulmonary and ear skin tissues, inflammation, and cell infiltration were determined by hematoxylin and eosin staining. The messenger RNA (mRNA) levels of TSLP, immunoglobulin E, interleukin (IL)-4, IL-5, and IL-13 were measured by real-time quantitative polymerase chain reaction. The protein expression of nuclear factor kappa B (NF-κB)/nuclear factor erythroid 2-related factor 2 (Nrf2) signaling-associated molecules (p-p65, p65, p-I kappa B kinase alpha (IκBα), IκBα, Nrf2, and TSLP) in lung and ear skin tissues were assessed by Western blot analysis.
Results: Resveratrol attenuated airway resistance and infiltration of total cells, eosinophils, and neutrophils in both lung and ear skin tissues. Resveratrol ameliorates serum inflammatory markers in allergic mice. Moreover, the phosphorylation levels of NF-κB pathway-related proteins were significantly reduced by administration of resveratrol in allergic lung and ear skin tissues. Similarly, the protein expression of TSLP in both lung and ear skin tissues was reduced by resveratrol, and Nrf2, a protector molecule, was increased with resveratrol treatment.
Conclusion: Resveratrol attenuates TSLP-reduced atopic march through ameliorating inflammation and cell infiltration in pulmonary and ear skin tissues by inhibiting the abnormal activation of NF-κB signaling pathway.
Atributos morfológicos, físicos y rendimiento en partidos en jugadores jóvenes de balonmano
Authors: Resina de Oliveira Campos Renato , Volossovitch Anna , Pereira Ferreira António Paulo 
Published: April 2024

The aim of this study was threefold: 1) to compare the morphological and physical attributes of the young players divided into two different maturational groups; 2) to analyze the association between the morphological and physical attributes and the game performance of young players, taking into account their maturational state; and finally 3) to verify if the subjective coach’s opinion about the individual performance and players’ potential is influenced by players’ game performance and the morphological and physical attributes. The sample consisted of 40 young handball players divided into pre- and post-peak height velocity. The morphological and physical attributes of players from each group, as well as the association of these attributes with the competitive performance were analyzed and compared. The results confirmed the significant differences between both groups in all morphological characteristics and the results of physical assessment. It was found that the morphological and physical attributes associated with better competitive performance differ according to the maturation state of the players. The study confirmed the importance of maturational assessment in the interpretation of physical tests results, morphological assessments and competitive performance of handball players in the ages near the pubertal growth spurt.
Сhronic rhinosinusitis in adult patients with cystic fibrosis receiving CFTR modulators
Authors: Shumkova G. L. , Amelina E. L. , Krasovskiy S. A. , Krylova N. A. 
Published: April 2024

Cystic fibrosis-associated chronic rhinosinusitis (CRS) is a separate form of CRS that progresses gradually over the course of patient’s life and worsens with age. The reasons for this are the mechanical congestion of mucus in the paranasal sinuses and the persistence of colonies of pathogenic antibiotic-resistant microorganisms. Therapy with CFTR modulators has resulted in a significant reduction in the severity of CRS. The nature of these changes and the dynamics in the microbial landscape of the upper respiratory tract are not sufficiently explored.Aim of the article is to highlight various aspects of the impact of CFTR modulators on the course of CRS in adult patients with cystic fibrosis (CF) based on literature data and a number of our own clinical observations. The article presents a series of clinical cases of CRS in adult CF patients treated with CFTR modulators for different periods of time.Conclusion. During targeted therapy with CFTR modulators, the symptoms of CRS are reversed due to the restoration of normal rheological properties of nasal secretions, the clinical picture improves, and the severity of CRS decreases. However, this type of treatment has no direct effect on the microbial landscape of the respiratory tract and requires additional interventions in the form of local and systemic antibacterial therapy. Therapy with CFTR modulators alters the course of CF in the nasal cavity, as well as in the pharynx and larynx.
Functional activity of the CFTR channel in a patient with the [L467F;F508del]/W1310X genotype
Authors: Krasnova M. G. , Mokrousova D. O. , Efremova A. S. , Melyanovskaya Yu. L. , Sherman V. D. , Bukharova T. B. , Goldshtein D. V. 
Published: April 2024

An important factor influencing the severity of cystic fibrosis (CF) and the effectiveness of treatment is the presence of complex alleles in the CFTR gene ≥ 2 variants in one allele. The influence of such alleles on the manifestations of CF has not been sufficiently studied.The aim of this study was to investigate the effect of the complex allele [L467F;F508del] on the phenotypic manifestations of CF and the efficacy of targeted therapy in an intestinal organoid (IO) model in a patient with the [L467F;F508del]/W1310X genotype.Methods. Methods for determining the difference in intestinal potentials (IDP), the KO method, and the forskolin test are presented using the medical history of a patient with the [L467F;F508del]/ W1310X genotype as an example.Results. The patient was diagnosed with progressive disease with obvious deterioration of pulmonary function. The ORKP method showed the absence of chlorine channel function. An assay with a KO culture from intestinal tissue showed a complete loss of functional activity of the chloride channel. In addition, the complex allele [L467F;F508del] is not sensitive to the effect of all tested CFTR modulators.Conclusion. The complex allele [L467F;F508del] causes a complete loss of functional CFTR protein and is not sensitive to the effect of any of the registered targeted drugs.
The first experience of using magnetic resonance tomography for lung imaging in children with cystic fibrosis: opportunities and prospects
Authors: Mustafin R. I. , Kustova O. V. , Simonova O. I. , Anikin A. V. 
Published: April 2024

Cystic fibrosis (CF) is a hereditary disease associated with systemic failure of the exocrine glands. In 95% of the cases, progressive damage to the lung tissue occurs that requires follow-up. The main imaging methods are radiography and computed tomography (CT). Both methods involve ionizing radiation. According to clinical guidelines, a chest X-ray is performed no more than once every 2 years. However, given the high risk of developing inflammatory processes in children with CF, the frequency of radiological examinations may increase significantly. The search for alternative methods without ionizing radiation is in great demand among children with CF. One of these methods is magnetic resonance imaging (MRI).The aim was to explore the capabilities of MRI for imaging lung tissue in children with CF.Methods. The study included 12 patients aged 7 to 18 years with newly diagnosed and previously diagnosed CF. All children underwent CT and MRI of the chest.Results. In all children (100%), chest CT revealed a complex of changes typical of CF: signs of chronic bronchitis, widespread saccular and cylindrical bronchiectasis of various localizations, areas of pulmonary fibrosis, infiltrative changes in the lung tissue. Chest MRI is most effective (100%) in identifying areas of pulmonary fibrosis (thickening of the lung tissue), accumulation of exudate in the lumen of bronchiectasis, and infiltrative changes. In contrast to CT, MRI is less effective in the assessment of bronchitis changes with thickening of the bronchial walls without exudate (83%). A low efficiency of MRI is observed in the visualization of bronchiectasis with a free lumen (without signs of mucostasis).Conclusion. Radiography and computed tomography remain the main methods for lung imaging in children with CF. However, taking into account the absence of ionizing radiation, the development of the method and the emergence of new sequences, chest MRI can be used effectively for follow-up instead of radiography and CT, reducing the radiation dose received.
Regional experience in monitoring children with cystic fibrosis on targeted therapy in the Republic of Tatarstan
Authors: Pyaterkina O. G. , Karpova O. A. , Begieva G. R. , Zinnatullin I. R. , Zakirov I. I. 
Published: April 2024

In connection with the introduction of targeted therapy for cystic fibrosis (CF) into clinical practice, there is a need to study the clinical effectiveness of these drugs and to record their possible side effects in children.The aim was to present the regional experience of the Republic of Tatarstan in the use of etiopathogenetic therapy (ivacaftor + tezacaftor + elexacaftor) in 41 children diagnosed with CF.Methods. Before initiation of triple therapy, a comprehensive assessment of body functions was carried out. Monitoring of safety and effectiveness was carried out at 14 days, 1 month, 3 months, 6 months, and 12 months after from the start of therapy.Results. In the first 2 weeks from the start of therapy, 10 (27%) patients reported mild side effects in the form of increased cough, sputum, and rhinorrhea, 2 (5,4%) patients had skin rashes, and 3 (8,1%) patients had elevated blood aminotransferases. One child developed encephalopathy due to arterial hypertension several months after starting therapy.Conclusion. Monitoring of the safety of the therapy over 12 months in children with CF showed a satisfactory profile. The therapy was associated with an improvement in the body functions, nutritional status, and quality of life.
Diagnosis and prevention of osteoporosis in children with cystic fibrosis
Authors: Zhekaite E. K. , Odinaeva N. D. , Voronkova N. Yu. , Maksimycheva T. Yu. , Sorokin A. S. 
Published: April 2024

Osteoporosis is a metabolic disease of the skeleton characterized by a decrease in bone mass, a disruption of the microarchitecture of bone tissue and, as a result, fractures with minimal trauma. The urgency of the problem of osteoporosis in children with cystic fibrosis arises from the high risk of a decrease in bone mineral density (BMD) in this category of patients.The aim is to investigate the patterns and mechanisms of bone mineral density reduction in children with cystic fibrosis.Methods. 100 patients with cystic fibrosis were examined. The control group included 61 healthy children aged 6 to 17 years. Alimentary and biochemical risk factors for the decrease in BMD were analyzed. X-ray densitometry was performed in children over 6 years of age using a DEXXUM device (South Korea). The concentration of calcidiol 25(OH)D and other biochemical parameters in blood were determined using the enzyme immunoassay method.Results. 62% of patients with CF and 82% of healthy children had normal BMD. The leading factors affecting BMD in patients with cystic fibrosis are: history of meconium ileus, chronic infection with Pseudomonas aeruginosa, lower indicators of nutritional status, and lower lung function (FEV1, %pred). The biochemical markers of osteoremodeling that determine the risk group for osteoporosis in patients with CF are osteocalcin and acid phosphatase. Healthy children who consumed more dietary calcium had better BMD. The effect of dietary calcium intake and vitamin D dose on BMD in patients with CF was not observed.Conclusion. The features of inflammatory and catabolic processes in cystic fibrosis influence the remodeling processes by reducing osteosynthesis and activating osteoresorption. In both groups of children studied, low nutritional status had a negative effect on BMD.
Pericardial tamponade secondary to
Salmonella enterica
serovar Enteritidis
Authors: Siddiqui Nida , Uzoegbo Sharon , Moola Husna , Ramchander Alisha , Chomba Rispah , Kukulela Nangamso , Nel Jeremy 
Published: April 2024

Abstract
Nontyphoidal Salmonella species usually cause self-limiting gastroenteritis. Extra-intestinal manifestations can occur, and purulent pericarditis is an extremely rare manifestation. It is potentially life-threatening, and a high index of suspicion is required to prevent morbidity and mortality. We report a case of Salmonella enterica serovar Enteritidis infection manifesting as life-threatening pericardial tamponade in a woman living with advanced HIV. It highlights a life-threatening manifestation of invasive nontyphoidal Salmonella species and the importance of appropriate treatment.
The effect of an educational video game on high school students’ motivation, self-efficacy and knowledge in a History course
Authors: Zapata Claudia , Navarro Ricardo , Vega Vanessa 
Published: April 2024

The purpose of this study was to explore the effects of an educational video game on high school students’ motivation, self-efficacy and knowledge. The game tells the story of Mariano Melgar, a Peruvian thinker, patriot and hero. The authors used a quasi-experimental design and conducted pre- and post-tests to estimate the effect of the video game. The sample consisted of 67 students from two schools in Lima. The students were randomly assigned to one of two conditions: playing a video game or watching a documentary. Results show that playing the video game was more effective in increasing students’ knowledge, whereas watching a documentary increased demotivation and decreased self-efficacy through vicarious experience. In view of this, it is important to explore further video games’ usefulness as educational materials.
Pengembangan Bahan Ajar Kalkulus Diferensial untuk Mahasiswa Program Studi Pendidikan Matematika FMIPA UNJ
Authors: Hajizah Mimi Nur , Ellis Salsabila  
Published: April 2024

Penelitian ini bertujuan untuk mengembangkan bahan ajar mata kuliah Kalkulus Diferensial untuk mahasiswa Program Studi Pendidikan Matematika FMIPA UNJ. Sebagai mata kuliah dasar, Kalkulus sangat penting untuk dipahami oleh mahasiswa didalam proses pembelajaran. Hal ini dikarenakan kalkulus sangat terkait dengan mata kuliah lainnya dan merupakan pondasi untuk mempelajari mata kuliah selanjutnya, seperti : Persamaan Diferensial, Analisis Real, Aljabar, Statistika Matematika, maupun mata kuliah lain yang bersifat aplikasi atau terapan. Sumber belajar mata kuliah Kalkulus yang selama ini digunakan di lingkungan Program Studi Pendidikan Matematika FMIPA UNJ adalah buku teks Kalkulus yang beredar di pasaran. Isinya sangat umum, sehingga dosen perlu memilah kembali materi-materi apa saja yang harus diberikan agar sesuai dengan capaian pembelajaran yang ditetapkan. Oleh karena itu, peneliti bermaksud untuk mengembangkan bahan ajar mata kuliah Kalkulus untuk mahasiswa Program Studi Pendidikan Matematika FMIPA UNJ. Penyusunan bahan ajar tersebut akan diselaraskan dengan Capaian Pembelajaran Lulusan Program Studi Pendidikan Matematika FMIPA UNJ. Desain penelitian yang digunakan dalam penelitian ini adalah penelitian pengembangan (R&D). Model pengembangan yang digunakan dalam penelitian ini adalah model penelitian dan pengembangan modifikasi dari model 4D (Define–Design–Develop–Disseminate).
From Streamline to Pathline: Visualizing Particle Trajectories Under Changing Velocity Fields
Authors: Li Ao , Chen Hongquan , Jalali Ridwan , Al-Darrab Abdulaziz 
Published: April 2024

Summary
Monitoring of subsurface fluid motion is critical for optimizing hydrocarbon production and CO2 sequestration. Streamlines are frequently used to visualize fluid flow; however, they provide only an instantaneous snapshot of the velocity field and do not offer an exact representation of fluid movement under varying field conditions. In contrast, pathlines are constructed by tracking individual particles within the fluid, enabling us to trace the movement of these particles as they traverse through changing velocity fields.
Pathline is the trajectory that an individual fluid particle follows in the reservoir. It can be thought of as “recording” the path of a fluid element in the flow field for a given time interval. Pathlines are distinct from streamlines which represent a snapshot of the velocity field at a given instant. The direction the path takes is determined by the streamlines at a specific instant. To start with, streamlines are traced based on the grid face fluxes of finite-difference simulation. Streamline tracing continues till the time of flight equals the current time. The endpoints of the current streamlines become the starting points for the next tracing period. Thus, our formulation incorporates changing flow fields, and the process is repeated for each time interval until the end.
The proposed injection monitoring method is tested using a 3D field-scale model with complex geologic features to demonstrate its power and utility. The pathlines were compared with streamlines, as well as the water saturation distribution. Three scenarios are tested: a constant well schedule, a changing well schedule with partial shut-in, and a changing well schedule with a whole field cessation. Results indicate that the pathline provides a more accurate swept volume, consistent with saturation distribution. The robustness of our algorithm and implementation is demonstrated with a complex embedded discrete fracture model (EDFM) to visualize flow patterns in discrete facture network. Pathlines display the fluid flow across fractures and are subsequently used to explore the sweep efficiency and the well connectivity.
Assessing the causality of interferon-γ and its receptor 1/2 with systemic lupus erythematosus risk using genetic data
Authors: Chang Minjing , Yao Kai-Xin , Hao Jia-Wei , Long Yin-Qi , Qiao Lu-Lin , Zhang Ya-Ru , Ma Ke-Xin , Zhang Sheng-Xiao , Li Xiao-Feng , He Peifeng 
Published: April 2024

Abstract

Background: The interferon-gamma (IFN-γ) signaling pathway is activated in systemic lupus erythematosus (SLE). This study aimed to assess the causal association between IFN-γ, IFN-γ receptor 1 (IFN-γR1), and IFN-γR2 and SLE using a bidirectional Mendelian-randomization design.
Methods: Genetic instruments for exposure to IFN-γ, IFN-γR1, and IFN-γR2 were derived from a large genome-wide association study (GWAS) that included a sample size of 3301 participants. Instrumental variables for SLE were selected from another independent GWAS analysis comprising 5201 cases and 6099 controls with European ancestry. Bidirectional two-sample Mendelian randomization (MR) was performed using inverse variance weighting, MR-Egger regression, and weighted median methods. A series of sensitivity analyses were conducted to assess the robustness of the results.
Results: The inverse variance weighting showed that IFN-γ had a positive causal association with the risk of SLE (odd ratio [OR]=1.24, 95% confidence interval [CI]: 1.03–1.47, P=0.018). IFN-γR2 levels were not associated with SLE risk after adjustment for multiple comparisons (OR=0.85, 95% CI: 0.73–0.99), P=0.034). No genetic association was also detected between IFN-γR1 and SLE (OR=0.97, 95% CI: 0.79–1.19), P=0.768). Evidence from bidirectional MR did not support reverse causality. The weighted median regression also showed directionally similar estimates.
Conclusion: Higher levels of IFN-γ are significantly associated with an increased risk of SLE, providing insights into the pathogenesis of SLE.