bluuebunny/crossref_metadata_2025_split huggingface dataset:
Palladium‐Catalyzed Two‐fold Annulation Reaction of 2,6‐Dihalogenobiphenyls with o‐Chloroaromatic Carboxylic Acids to Access (Aza)dibenzo[fg,op]tetracenes
Authors: Zhu Ji‐Fa , Li Song , Long Xin‐Yuan , Shi Yingbo , Wang Bi‐Qin , Feng Chun , Ni Hai‐Liang , Xiang Shi‐Kai 
Published: April 2024

AbstractA palladium‐catalyzed two‐fold annulation reaction of 2,6‐dihalogenobiphenyls with o‐chloroaromatic carboxylic acids has been developed. This method enables the synthesis of various dibenzo[fg,op]tetracenes and azadibenzo[fg,op]tetracenes. Preliminary investigations indicate that the resulting product, dimethyl 5,6,12,13‐tetrakis(hexyloxy)dibenzo[fg,op]tetracene‐2,9‐dicarboxylate, demonstrates favorable liquid‐crystalline properties.
The ARPKD Protein DZIP1L Regulates Ciliary Protein Entry by Modulating the Architecture and Function of Ciliary Transition Fibers
Authors: Chen Huicheng , Wu Zhimao , Yan Ziwei , Chen Chuan , Zhang Yingying , Wang Qiaoling , Gao Yuqing , Ling Kun , Hu Jinghua , Wei Qing 
Published: April 2024

AbstractServing as the cell's sensory antennae, primary cilia are linked to numerous human genetic diseases when they malfunction. DZIP1L, identified as one of the genetic causes of human autosomal recessive polycystic kidney disease (ARPKD), is an evolutionarily conserved ciliary basal body protein. Although it has been reported that DZIP1L is involved in the ciliary entry of PKD proteins, the underlying mechanism remains elusive. Here, an uncharacterized role of DZIP1L is reported in modulating the architecture and function of transition fibers (TFs), striking ciliary base structures essential for selective cilia gating. Using C. elegans as a model, C01G5.7 (hereafter termed DZIP‐1) is identified as the sole homolog of DZIP1L, which specifically localizes to TFs. While DZIP‐1 or ANKR‐26 (the ortholog of ANKRD26) deficiency shows subtle impact on TFs, co‐depletion of DZIP‐1 and ANKR‐26 disrupts TF assembly and cilia gating for soluble and membrane proteins, including the ortholog of ADPKD protein polycystin‐2. Notably, the synergistic role for DZIP1L and ANKRD26 in the formation and function of TFs is highly conserved in mammalian cilia. Hence, the findings illuminate an evolutionarily conserved role of DZIP1L in TFs architecture and function, highlighting TFs as a vital part of the ciliary gate implicated in ciliopathies ARPKD.
Toward Reliable Synthesis of Superconducting Infinite Layer Nickelate Thin Films by Topochemical Reduction
Authors: Gutiérrez‐Llorente Araceli , Raji Aravind , Zhang Dongxin , Divay Laurent , Gloter Alexandre , Gallego Fernando , Galindo Christophe , Bibes Manuel , Iglesias Lucía 
Published: April 2024

AbstractInfinite layer (IL) nickelates provide a new route beyond copper oxides to address outstanding questions in the field of unconventional superconductivity. However, their synthesis poses considerable challenges, largely hindering experimental research on this new class of oxide superconductors. That synthesis is achieved in a two‐step process that yields the most thermodynamically stable perovskite phase first, then the IL phase by topotactic reduction, the quality of the starting phase playing a crucial role. Here, a reliable synthesis of superconducting IL nickelate films is reported after successive topochemical reductions of a parent perovskite phase with nearly optimal stoichiometry. Careful analysis of the transport properties of the incompletely reduced films reveals an improvement in the strange metal behavior of their normal state resistivity over subsequent topochemical reductions, offering insight into the reduction process.
Recent Progress on Copper‐Based Bimetallic Heterojunction Catalysts for CO2 Electrocatalysis: Unlocking the Mystery of Product Selectivity
Authors: Huang Jiabao , Zhang Xinping , Yang Jiao , Yu Jianmin , Chen Qingjun , Peng Lishan 
Published: April 2024

AbstractCopper‐based bimetallic heterojunction catalysts facilitate the deep electrochemical reduction of CO2 (eCO2RR) to produce high‐value‐added organic compounds, which hold significant promise. Understanding the influence of copper interactions with other metals on the adsorption strength of various intermediates is crucial as it directly impacts the reaction selectivity. In this review, an overview of the formation mechanism of various catalytic products in eCO2RR is provided and highlight the uniqueness of copper‐based catalysts. By considering the different metals' adsorption tendencies toward various reaction intermediates, metals are classified, including copper, into four categories. The significance and advantages of constructing bimetallic heterojunction catalysts are then discussed and delve into the research findings and current development status of different types of copper‐based bimetallic heterojunction catalysts. Finally, insights are offered into the design strategies for future high‐performance electrocatalysts, aiming to contribute to the development of eCO2RR to multi‐carbon fuels with high selectivity.
Tailwater recovery systems can improve water quality: An area ripe for research in cranberry agriculture
Authors: Kennedy Casey D. , Omer Austin , Wiegman Adrian R. H. , Welsh Molly K. , Millar David , Buda Anthony R. 
Published: April 2024

AbstractTailwater recovery (TWR) systems, which divert phosphorus‐rich drainage water from cranberry (Vaccinium macrocarpon Ait.) farms into reservoirs, have the potential to improve water quality of freshwater lakes in Massachusetts. However, residents and environmentalists have questioned the potential water quality benefits of TWR systems. In the southeastern United States, research shows that TWR systems decrease agricultural inputs of phosphorus (P) to surface water by 23%–92%. Additionally, a case study in Massachusetts demonstrated the efficacy of TWR and other best management practices in reducing P concentrations in White Island Pond. Although TWR systems appear effective as part of a P management strategy, more research is needed to quantify their environmental benefits and allay public concerns. We propose filling three critical research gaps to strengthen and broaden support for TWR systems in cranberry agriculture in Massachusetts: (1) quantifying physical properties, (2) quantifying water storage potential, and (3) quantifying P retention capacity.Core Ideas
Excess phosphorus (P) from cranberry farms may contribute to the eutrophication of freshwater lakes.
Agricultural tailwater recovery (TWR) systems are increasingly used to conserve water and improve water quality.
Earth removal, critical to create TWR ponds and provide sand for cranberry farms, has drawn public opposition.
Research and case studies indicate TWR systems may decrease P inputs from cranberry farms to surface water.
Long‐term monitoring, research, and stakeholder engagement are needed to assess efficacy of cranberry TWR systems.
Stock assessment and reproductive biology of bluespotted seabream Pagrus caeruleostictus (family: Sparidae)
Authors: Clottey Michelle Naa Kordei , Aggrey‐Fynn Joseph , Blay John , Kwasi Arizi Evans 
Published: April 2024

AbstractBluespotted seabream Pagrus caeruleostictus, a member of the family Sparidae, is one of the high‐priced seabream species in Ghana. Although the fish has been exploited in the Gulf of Guinea for over hundreds of years, there is scanty information on the state of the fish stock. Hence, we sought to investigate the exploitation status and aspects of the reproductive biology of the species by collecting monthly length and weight data for 18 months (February 2016 to July 2017). These data were fitted to growth and mortality models. The sexual maturity, fecundity and spawning seasons were also determined within the same period. The growth model of the fish revealed that the asymptotic length (L∞) and growth coefficient (K) values determined were 52.7 cm (total length) and 0.52 year−1, respectively. The mortality models also showed that the fishing mortality (F) of the fish was 2.20 year−1, whereas its natural mortality (M) was 0.83 year−1, with F/M > 0.5 indicating that the fish is over‐exploited. The lengths at first sexual maturity (Lm) of the males and females were 36.2 and 28.0 cm, respectively. Pagrus caeruleostictus, which was found to be highly fecund, had two spawning periods in a year, occurring in September and March, both with unimodal ova diameter frequency distributions. Based on these findings, we recommend that catch limits and other appropriate management measures (e.g. temporal and spatial closures) should be prescribed for the seabream fishery in the Gulf of Guinea to ensure the sustainability of the fishery.
Electron Donor‐Acceptor (EDA) Complex Enabled C−C Cross‐Coupling Reactions of α‐Amino Radicals
Authors: Barik Padmanava , Behera Subhra Sriharsa , Nanda Santosh Kumar 
Published: April 2024

AbstractElectron‐donor acceptor (EDA) complex has been an integral part of visible‐light photocatalysis and is different from the traditional photoredox catalysis, which requires an exogenous photocatalyst, typically a colored compound to initiate the photocatalytic cycle. Interestingly, the EDA‐complex photochemistry has found profound use in activating the inert α‐C−H bonds of amines. The strategy relied upon the formation of colored EDA‐complex between the donor (amine) and acceptor (Lewis acid), which upon harvesting light energy perform a SET process to generate radical cation and anion intermediates. The radical cation then loses the activated acidic proton (because of the SET, the acidity of α‐proton increases by lowering the BDE) to form α‐amino radical, which then participates in various C−C coupling cascades. In this review, different conceptual approaches for the generation of α‐amino radicals and their coupling for the C−C bond‐forming reaction under EDA‐complex triggered photocatalysis will be discussed with particular emphasis on the reaction mechanism from 2018 onwards.
Ultrasound assessment of acute Achilles tendon rupture and measurement of the tendon gap
Authors: Fenech Michelle , Ajjikuttira Aiyapa , Edwards Heath 
Published: April 2024

AbstractAchilles tendon rupture is a common sports‐related injury which can carry significant morbidity to patients. Ultrasound remains the workhorse of imaging as it can confirm and localise the extent of Achilles tendon injury. The sonographic anatomy, both normal and ruptured sonographic appearances, as well as sonographic technique must be appreciated to accurately image and report findings, critical to patient management. Particular attention should be applied to the measurement of the diastasis between acutely ruptured tendon ends as this information can assist with informing the decision of conservative vs. operative management. Further work is necessary to standardise the measurement technique including correlating the degree of plantarflexion of the foot with the sonographic tendon gap measures.
Enhancing the performance of poly(ethylene oxide) solid electrolytes through synergistic interaction of starch and butanedinitrile
Authors: Zhao Tuo , Yang Jingjing , Cai Lifan , Zhu Wanxin , Wu Xinming , Shao Le 
Published: April 2024

AbstractSolid polymer electrolyte (SPE) is one of the key materials being researched as the core component of all‐solid‐state lithium batteries, which are safer and helpful for higher energy densities. Although there has been extensive research, unifying electrochemical performance with environmental requirements is the new requirement of SPE. Here, natural and harmless starch is used as a filler to modify PEO‐based SPE, which are prepared using a simple solution casting method. Characterizations show that the electrochemical and mechanical properties of SPEs are both significantly improved through the interaction among PEO, starch and SN. The tensile strength increases by about 50%. The ionic conductivity reaches to 4.8 × 10−5 S cm−1 at 30°C, with the Li+ transfer number is 0.2 at 80°C. The electrochemical window of PEO/LiClO4/starch/SN SPE is about 5 V. For the Li/PEO/LiClO4/starch/SN SPE/Li symmetric cell, it gives stable lithium plating/stripping at 80°C for over 900 h at a current density of 0.1 mA cm−2. These results provide a new idea for the green development of solid‐state electrolytes.
4D printing of dual‐responsive high‐performance shape memory polymer inspired by sunflowers
Authors: Shan Wubin , Liang Lei , Wu Linmei 
Published: April 2024

AbstractA dual‐responsive shape memory polymer, inspired by the heliotropic behavior of sunflowers, holds promise for innovative research, amalgamating the distinctive traits of shape memory polymers with nature's sunflower dynamics. In this investigation, we crafted a heat and light dual‐responsive shape memory polymer through liquid crystal display 3D printing technology, employing a meticulously formulated resin composition. The resin comprised epoxy acrylate as an oligomer, hydroxyethyl methacrylate as a monomer, and phenylic(2,4,6‐trimethylbenzoyl) phosphine oxide as a photo initiator. To confer light responsiveness, graphene oxide particles were integrated into the polymer matrix, designed to selectively absorb light wavelengths and instigate the shape memory effect upon light exposure. The resultant shape memory polymer showcased exceptional mechanical robustness and manifested superior responsiveness to temperature and light stimuli. This light‐responsive shape memory polymer, drawing inspiration from sunflowers, presents numerous potential applications, such as transfer printing, as demonstrated.
Development of co‐electrospun membrane composed poly(l‐co‐d,l‐lactic acid) and natural rubber with potential application in dermal dressing
Authors: Pinto Marcelo Formigoni , V. Quevedo Bruna , Komatsu Daniel , de Moraes Stephen Christina , Duarte Marcia Adriana Tomaz , Duek Eliana Aparecida de Rezende 
Published: April 2024

AbstractWound healing represents a global challenge for the healthcare system, resulting in substantial costs and physical and emotional impacts on individuals. There is an increasing demand for innovative alternatives to treat this condition. The co‐electrospinning technique enables the production of porous membrane composed of natural and synthetic polymers, which exhibit unique functions and adjustable mechanical properties that assist in the tissue healing process. Therefore, the present study aims to investigate the physical–chemical, mechanical, and biological properties of membrane composed of poly(l‐co‐d,l‐lactic acid) (PLDLA) co‐electrospun with different concentrations of natural rubber (NR) (1.5%, 2.0%, and 2.5%). Scanning electron microscopy analysis revealed the porous surface of the membranes. Fourier‐transform infrared spectroscopy confirmed the presence of NR in the material. The low Young's modulus obtained in the mechanical tensile test for the PLDLA membrane co‐electrospun with 1.5% NR indicated its elastic capacity under low tension. The results corroborate with the differential scanning calorimetry, and thermogravimetric analysis, which highlights the compatibility between polymers at this specific proportion, as well as in vitro biocompatibility. The findings underscore the potential of PLDLA and NR co‐electrospun membranes as promising candidates for formulating biomaterials for applications such as dermal dressings.
Molecularly imprinted hydrazidine‐derived poly(acrylonitrile‐co‐divinylbenzene for enantio‐recognition of S‐fenoprofen
Authors: Alhawaiti Abeer A. , Almutairi Fahad M. , Elsayed Nadia H. 
Published: April 2024

AbstractThe drug fenoprofen (FN) is available in two forms, R‐ and S‐enantiomers, which need to be separated for optimal therapeutic use. A novel poly(acrylonitrile‐co‐divinylbenzene) (PNB)‐based polymer sorbent designed specifically for S‐fenoprofen (S‐FN) enantioseparation was synthesized. This process began with creating low cross‐linked PNB microparticles through suspension polymerization. Next, hydrazine was introduced to react with the prevalent nitrile groups. The produced cationic hydrazidine‐functionalized polymer particles (HYD‐P) were then combined with anionic S‐FN. The imprinting of S‐FN was achieved by further cross‐linking with glutaraldehyde, which interacted with the NH2 groups. Subsequent acidic elution released the S‐FN enantiomers, leaving behind their specific receptor‐like cavities in the imprinted polymer particles (S‐FN‐P). The properties of the resulting polymers were analyzed using Fourier‐transform infrared (FTIR), 13C NMR, and x‐ray diffraction. Scanning electron microscopy was used to examine the surface structures of the sorbents. Under optimal conditions at pH 7, the sorbent showed an adsorption capacity of 240 mg/g for S‐FN. The chiral separation of the FN racemate achieved high enantiomeric excess (ee) levels, with 96% for R‐FN during loading and 94% for S‐FN during recovery.
Highly Stretchable Polyurethane Porous Membranes with Adjustable Morphology for Advanced Lithium Metal Batteries
Authors: Hussain Arshad , Mehmood Andleeb , Raza Waseem , Faheem Muhammad , Saleem Adil , Kashif Majeed Muhammad , Iqbal Rashid , Aziz Md. Abdul 
Published: April 2024

AbstractA highly flexible, tunable morphology membrane with excellent thermal stability and ionic conductivity can endow lithium metal batteries with high power density and reduced dendrite growth. Herein, a porous Polyurethane (PU) membrane with an adjustable morphology was prepared by a simple nonsolvent–induced phase separation technique. The precise control of the final morphology of PU membranes can be achieved through appropriate selection of a nonsolvent, resulting a range of pore structures that vary from finger–like voids to sponge–like pores. The implementation of combinatorial DFT and experimental analysis has revealed that spongy PU porous membranes, especially PU−EtOH, show superior electrolyte wettability (472%), high porosity (75%), good mechanical flexibility, robust thermal dimensional stability (above 170 °C), and elevated ionic conductivity (1.38 mS cm−1) in comparison to the polypropylene (PP) separator. The use of PU−EtOH in Li//Li symmetric cell results in a prolonged lifespan of 800 h, surpasing the longevity of PU or PP cells. Moreover, when subjected to a high rate of 5 C, the LiFePO4/Li half‐cell with a PU−EtOH porous membrane displayed better cycling performance (115.4 mAh g−1) compared to the PP separator (104.4 mAh g−1). Finally, the prepared PU porous membrane exhibits significant potential for improving the efficiency and safety of LMBs.
‘What happens then?’: A 6‐month follow‐up on students accessing a university counselling service
Authors: Bani Marco , Zorzi Federico , Russo Selena , Ardenghi Stefano , Rampoldi Giulia , Strepparava Maria Grazia 
Published: April 2024

AbstractIntroductionUniversity psychological counselling services represent a frontline defence to detect, treat or refer students with a wide range of (clinical and non‐clinical) difficulties. Nevertheless, only few studies describe their impact on academic self‐efficacy and report follow‐up data. Evidence on students' actual access to further psychological support in times of hardship is also scant and most needed. This study aimed to fill these gaps, exploring the stability of improvement in clinical conditions in a wide sample of university students and reporting post‐intervention referrals to mental health services.MethodsIn a longitudinal study, 218 students who accessed a psychological counselling service at the University of Milano‐Bicocca between 2015 and 2019 completed an assessment at the beginning (T0), conclusion (T1) and 6 months after (T2) a brief cognitive behavioural intervention. The assessment included psychological symptoms, general distress, emotion dysregulation and academic self‐efficacy. Information about students' choices to continue a psychological intervention in other services was also collected and contrasted with the counsellor's indication.ResultsAt follow‐up, the improvement in academic self‐efficacy remained stable, with more than 60% of the students maintaining a reliable clinical change, and nearly half of them reporting having accessed (or being willing to contact) a mental health service outside the university services.ConclusionThese findings highlight the key role of counselling services in addressing students' distress and academic performances in the long term and in building bridges with mental health services outside the university system for students who need longer and specialised treatment.
Two New Phenylpropanoid Compounds from Lilium Brownii and Their Anti‐monoamine Oxidase Activity
Authors: Hui Chengcheng , He Shuaibo , Ji Mengshan , Zhang Yuhang , Wang Haibo , Wang Xiaowei , Guo Tao 
Published: April 2024

AbstractBaihe is a commonly used Chinese medicine for the treatment of neurological disorders. Clinically, the bulbs of Lilium brownii are used to act as Baihe. In the study, two new phenylpropanoid compounds including 3‐O‐acetyl‐1‐O‐caffeoylglycerol (1) and 3‐O‐acetyl‐1‐O‐p‐coumaroylglycerol (2) were isolated from the bulbs of L. brownii. Their structures were identified by spectroscopic method and the effect on monoamine oxidase activity was determined using an enzyme labeling method. The results show 1 and 2 have anti‐monoamine oxidase activity with 20.96 % and 22.31 % inhibition rates at 50 μg/ml, respectively.
Click, Compute, Create: A Review of Web‐based Tools for Enzyme Engineering
Authors: Tripp Adrian , Braun Markus , Wieser Florian , Oberdorfer Gustav , Lechner Horst 
Published: April 2024

AbstractEnzyme engineering, though pivotal across various biotechnological domains, is often plagued by its time‐consuming and labor‐intensive nature. This review aims to offer an overview of supportive in silico methodologies for this demanding endeavor. Starting from methods to predict protein structures, to classification of their activity and even the discovery of new enzymes we continue with describing tools used to increase thermostability and production yields of selected targets. Subsequently, we discuss computational methods to modulate both, the activity as well as selectivity of enzymes. Last, we present recent approaches based on cutting‐edge machine learning methods to redesign enzymes. With exception of the last chapter, there is a strong focus on methods easily accessible via web‐interfaces or simple Python‐scripts, therefore readily useable for a diverse and broad community.
Comparison of Classical and Green RPLC Methods in the Determination of pKa Values of Some Piperazine Group Antihistamines
Authors: Nane İkbal Demet , Çubuk Demiralay Ebru , Daldal Y. Doğan 
Published: April 2024

AbstractIn this study, protonation constant values and liquid chromatographic behaviors of hydrophobic cyclizine, chlorcyclizine, hydroxyzine, cinnarizine, cetirizine, meclizine, and buclizine in some water‐organic solvent binary mixtures were examined for the first time using classical and green reverse phase liquid chromatography methods. In the isocratic study, the relationship of the retention time and mobile phase pH in water‐organic solvent binary mixtures containing acetonitrile (45, 50, 55, 60, 65%, v/v), methanol (60, 65, 70, 75%, v/v) and ethanol (45, 50, 55, 56, 59, 60, 62, 65%, v/v) were determined at 37 °C. In the study, XBridge C18 and Gemini NX C18 columns suitable for the chemical properties of basic compounds were used. The obtained liquid chromatographic data were analyzed using the linear solvation energy relationship methodology and the SOLVER program. The aqueous protonation constant values of the investigated compounds were calculated using the linear relationship between the protonation constant data calculated in studied binary mixtures and some macroscopic constant values of the solvents used. The greenness of methods developed using three different solvents was evaluated with the Analytical Greenness Metric Approach, the Green Analytical Procedures Index, and the Green Solvent Selection Tool approaches.