bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mental Health, Professional Burnout, and Substance Use Screening Among High School Education Staff in Jalisco, Mexico. A Digital Survey from 2021
Authors: López Jesús Alejandro Aldana , Huerta Jaime Carmina , Sánchez Ana Victoria Chávez , Bizarro Alicia Denisse Flores , Sierra Jorge Antonio Blanco , Galindo Karem Isabel Escamilla , Mendoza Lorena Noemí Prieto , Cárdenas Ernesto Herrera , García Tanya Lahud , Venegas Nicolás Páez 
Published: April 2024

Abstract
Background: Education professionals often experience high levels of stress, burnout, and mental health problems due to the demanding nature of their work. Limited research has been conducted on these issues among education staff in Mexico. This study aimed to assess the prevalence of mental health problems, professional burnout, and substance use among high school education staff in the High School Education System of the University of Guadalajara, Jalisco, Mexico.
Methods: A total of 3,333 education staff members from 45 public high schools participated in an online self-report survey between March and June 2021. Validated instruments measured mental health using the General Health Questionnaire (GHQ-28), the Maslach Burnout Inventory (MBI) to assess burnout, and the Alcohol, Smoking and Substance Involvement Screening Test (ASSIST) to measure substance use. Descriptive statistics and regression analyses were performed.
Results: Nearly 30% of staff reported mental health problems, with somatic symptoms (45.2%) and anxiety/insomnia (41.3%) being the most common. Gender, marital status, and job role were associated with mental health, with women and those experiencing higher stress positions showing higher impairment. The MBI revealed that 17.49% of staff exhibited burnout, primarily characterized by emotional exhaustion. Interestingly, the personal accomplishment subscale deviated from the expected pattern. Substance use was also common, with alcohol and tobacco being the most frequently consumed substances. A significant association was found between substance use and mental health problems. Working hours had a weak correlation with burnout on their own, but a moderate correlation when combined with GHQ-28 scores, suggesting a cumulative burden on staff.
Conclusions: This study reveals a significant burden of mental health problems, burnout, and substance use among high school education staff in Jalisco, Mexico. These findings highlight the urgent need for targeted interventions to promote staff well-being, such as providing mental health resources, implementing stress management programs, and offering support for healthy coping strategies. Prioritizing the well-being of education staff is crucial for maintaining a high-quality educational environment and supporting the development of future generations.
Physical Literacy-Based Intervention for Chronic Disease Management: A Quasi-Experimental Study Protocol
Authors: Mouton Alexandre , Weerts Jean-Pierre , Carl Johannes 
Published: April 2024

Abstract

Background
As chronic diseases proliferate globally, innovative interventions that promote sustainable physical activity are crucial. Physical literacy - conceptualised as integrating motivation, confidence, physical competence, knowledge, social interaction, and engagement in meaningful activities - offers a holistic strategy for lifelong health promotion. This protocol describes a study investigating the effects of a physical literacy-based intervention on adults with chronic diseases, aiming to enhance long-term physical activity adherence and improve health outcomes.
Methods
This quasi-experimental study will compare three groups: a control group, a group taking part in traditional physical activity (TPA) group sessions tailored for adults with chronic disease focusing on physical fitness general improvement, and a group taking part in TPA sessions that incorporates physical literacy goals and intervention content in line with 6 core dimensions of physical literacy (TPA + PL). Intervention groups will take part in 12 one-and-a-half-hour sessions organised weekly over a 3-month cycle. The study will assess the impact of these interventions using a mixed qualitative and quantitative physical literacy assessment tool at baseline, three months (post-intervention), and six months (follow-up).
Discussion
The study protocol proposes a comprehensive approach to chronic disease management through physical literacy, hypothesising that integrating physical literacy dimensions in tailored physical activity group sessions can significantly improve physical literacy, and consequently physical activity sustainability and health outcomes. Results from this study will provide insights into the efficacy of physical literacy interventions compared to traditional approaches, potentially guiding future public health initiatives and chronic disease management strategies.
Trial registration
NCT06325306 (21/03/2024).
A mobile app to challenge obsessional beliefs in adolescents: A protocol of a two-armed, parallel randomized controlled trial
Authors: Saman Yuliya , Pascual-Vera Belén , Corberán Marta , Arnáez Sandra , Roncero María , García-Soriano Gemma 
Published: April 2024

Abstract

Background Adolescence is a crucial stage for the development of OCD symptoms that, in most cases, persist into adulthood. This requires designing preventive strategies tailored to this population. Therefore, we aim to describe the study protocol that will be used to examine the effectiveness of a mobile health application to challenge obsessional beliefs in adolescents. Methods A two-armed randomized controlled trial will be conducted on an adolescent sample from the general population. The experimental group will use the intervention module (GGOC-AD) of a mobile app on the GGtude platform for 14 days whereas the control group will use a non-active module (GGN-AD) of said app. Primary outcome measures will be obsessional beliefs and obsessive-compulsive symptoms, and secondary measures will be self-esteem and emotional symptoms. Three assessment points will be conducted at baseline, post-intervention, and one-month follow-up. A linear multiple regression model with an intention to treat approach will be used. The expected total sample size will be 55 participants. Discussion We expect that the intervention group will show a reduction in obsessional beliefs and OCD-symptoms at post and follow-up in comparison with the control group. Additionally, we expect that the app will improve participants’ self-esteem. This study could provide an accessible mobile health tool to prevent OCD-related symptoms in adolescents. Trial registration: ClinicalTrials.gov identifier: NCT06033391. Registered September 4, 2023, https://clinicaltrials.gov/study/NCT06033391
Emerging Technique: Stag Beetle Knife for Zenker's Diverticulum - A Meta-Analysis of Safety and Efficacy
Authors: Bhatia Mannat K , Ogwor Oghenfejiro , Doukas Panagiotis G , Bhatia Mehar K , Doukas Sotirios , Mohan Babu P. , Broder Arkady 
Published: April 2024

Abstract
Background and aim:
The SB Knife, a unique scissor-shaped device with rotating insulated monopolar blades, is increasingly employed in the endoscopic management of ZD, and this systematic review and meta-analysis aims to evaluate its overall safety, efficacy, and feasibility.
Methods
A thorough search of electronic databases and conference abstracts was conducted until November 2023. Meta-analysis utilized the random-effects model, with I2% assessing heterogeneity. Subgroup analysis was based on sample size, employing SMD and a 95% confidence interval (CI) for continuous variables. Key outcomes included clinical success, recurrence rate, adverse events, and improvement in dysphagia score.
Results
Incorporating eight studies with 299 patients (60.5% males), mean age 72.75 ± 2.86 years, and ZD size 2.66 ± 0.52 cm, procedures lasted 23.06 ± 10.00 minutes. Clinical success was achieved in 86% (95% CI: [81–90; I2 0%]) after 10.98 sessions and 22.74% required multiple (up to 4) sessions. The recurrence rate was 15% [11–20; I2 0%]. Intraprocedural complications occurred in 9% [5–13; I2 = 29%], primarily minor bleeding (9.6%), micro-perforation (2%), odynophagia (1.3%), and fever (1.05%). Late-onset bleeding occurred in 3.2% after 1 week. Adverse events were conservatively managed, and subgroup analysis by sample size indicated a significant difference in mean sessions (p = 0.02). Dysphagia score improvement was SMD (95% CI) 1.59 [2.27–0.91; I2 97%], p < 0.01, with a mean 22.23 ± 11.47 months follow-up.
Conclusion
The meta-analysis confirms SB knife's success in ZD, displaying excellent safety and dysphagia improvement; however, further research is needed to define optimal patient cohorts and compare them with other management techniques.
Can DRD2 Gene Affect Mathematical Ability? The Impact of a Working Memory-Associated Gene on Mathematical Ability
Authors: Yang Qing , Zhang Ximiao , Zhang Liming , Cheng Chen , Zhao Jingjing 
Published: April 2024

Abstract
Mathematical ability is influenced by various factors, particularly environment and genetics. This study focused on the effect of DRD2, a candidate gene for working memory, on mathematical ability. Our analysis of the DRD2 gene and mathematical ability performance in child participants revealed associations between the DRD2 gene and mathematical ability. It was found that individual's mathematical abilities are influenced by single nucleotide polymorphisms (SNPs) in DRD2, both in the form of haplotypes and in the way the gene interacts with parental education. The results also showed that mathematical ability is influenced by multiple genes. These findings suggest that dopaminergic genes may be linked to mathematical ability. Additionally, dopaminergic genes affect the development of children's mathematical ability by regulating working memory and related brain functions and structures. This study provides important insights into the genetic basis of mathematical ability and offers guidance for individual learning and education.
The Effect of Physical Stability and Modified Gastrointestinal Tract Behaviour of Resveratrol-Loaded NLCs Encapsulated Alginate Beads
Authors: Manikandan Sangeethkumar , Jose Preethy Ani , Karuppaiah Arjunan , Rahman Habibur 
Published: April 2024

Abstract

Nanostructured lipid carriers (NLC) have low storage and gastrointestinal stability, limiting their applicability. The work aimed to elevate the stability and behaviour of NLC in the alimentary tract by creating an Alginate bead. Through the extrusion dropping procedure, Resveratrol (RES) loaded NLC were efficiently integrated into alginate beads. The incorporation had no significant impact on the particle size, morphology, or inner structure of NLC, as assessed using DLS (Dynamic Light Scattering), SEM (Scanning Electron Microscopy), Differential Scanning Calorimetry (DSC) and FT-IR (Fourier Transform Infra-Red). Incorporating NLC into alginate beads improves its physical stability compared to Dispersion of NLC as well as NLC-Sol. An in vitro release investigation found that the NLC-alginate beads released RES more slowly than optimized NLC formulation (RES-NLCs-opt) and NLC-alginate sol. Research on simulated in vitro digestive models revealed that just a small amount of integrated NLC may permeate stomach fluid due to its tiny size. The slow diffusion of NLC from alginate to intestinal fluid prevented aggregation and allowed for gentle hydrolysis of the lipid matrix. Incorporating NLC in alginate beads shows promise for improving stability, modifying gastrointestinal behaviour, and controlling release throughout the process of digestion.
Altered brain functional networks in patients with breast cancer after neoadjuvant chemotherapy Running title: Disrupted Network in Breast Cancer After Chemotherapy
Authors: Yang Jing , Deng Yongchun , Liu Daihong , Hu Yixin , Tang Yu , Zhou Xiaoyu , Tan Yong , Zhang Jing , Liu Jiang , Wang Chengfang , Zeng Xiaohua , Zhang Jiuquan 
Published: April 2024

Abstract
Background In this study, we prospectively investigated changes in the brain connectome at multiple time points in breast cancer (BC) patients treated with neoadjuvant chemotherapy (NAC).
Methods Fifty-five participants with a diagnosis of BC underwent clinical assessments and fMRI at three timepoints, including before NAC (tp1), after the first cycle of NAC (tp2), and the end of the NAC regimen (tp3). Two matched healthy controls (HCs) groups received the same assessments at matching time points were also enrolled. Brain functional networks were constructed and analyzed using graph theory approaches to quantify the effect of NAC on brain cognitive dysfunction. We analyzed changes in brain connectome metrics both in HC and patient group and explored the relationship between these changes and clinical scales. Patient-subgroups were created by clinical subtype, chemotherapy regimen and menopausal status, and longitudinal subgroup analysis was performed.
Results There were no longitudinal differences within the two HC groups, and no differences between the two HC groups and patient group at tp1. BC patients who underwent NAC showed significantly increased global efficiency (p = 0.032), decreased characteristic path length (p = 0.020), and altered nodal centralities mainly in the frontal-limbic system and cerebellar cortex. There were few changes between the two chemotherapy sessions. Changes in the topological parameters were correlated with changes in clinical scales but did not differ between subgroups.
Conclusions Our findings demonstrated that NAC might affect brain functional connectivity in BC patients, especially in the early stage.
Exploring the Evaluation of Ecological Security of Water Resources in the Yangtze River Basin under the Background of Ecological Sustainable Development
Authors: Zhou Jie-Rong , Li Xiao-Qing , Yu Xin , Zhao Tian-Cheng , Ruan Wen-Xi 
Published: April 2024

Abstract
This paper constructs an indicator system for the ecological security of water resources in the Yangtze River Basin using theories related to ecological population evolution and the DPSIR (Driving forces-Pressures-States-Impacts-Responses) model. It assesses the ecological security status of water resources in the provinces of the Yangtze River Basin from 2010 to 2019, identifies the development trends of ecological security of water resources in these provinces, and proposes corresponding strategies for regional ecological security and economic coordination development. According to the results of the ecological population evolution competition model, the overall ecological security indicators of water resources in the Yangtze River Basin have continuously improved, with safety levels increasing year by year. In the Yangtze River Basin, maintaining robust management of water resources is crucial for the sustainable development of the social economy. Based on this, with the aim of further promote the ecological safety of water resources in the Yangtze River Basin and the coordinated development of regional economy, this paper proposes policy recommendations such as promoting the continuous advancement of sustainable development projects, actively adjusting industrial structures, enhancing public environmental awareness continuously, and actively participating in international ecological construction to seek multi-sectoral cooperation.
The causative effect of CXCR7 on experimental autoimmune prostatitis injury and fibrosis
Authors: zhang Yi , Feng Rui , Wu Weikang , Liu Xianhong , Huang Cong , Chen Xianguo , Chen Jing , Liang Chaozhao 
Published: April 2024

Abstract
Chronic prostatitis and Pelvic Pain syndrome (CP/CPPS) is an autoimmune inflammatory disease characterized by pelvic or perineal pain and infiltration of inflammatory cells in the prostate. C-X-C chemokine receptor type 7 (CXCR7), also known as the atypical chemokine receptor 3 (ACKR3) receptor, are atypical chemokine receptors. Having been shown to play a key role in inflammatory processes, whether CXCR7 influences the role of autoimmune prostate and immune regulation and its mechanism of action are unclear. In this study, a mouse model of experimental autoimmune prostatitis was constructed by subcutaneous injection of antigen, and CXCR7 agonist was administered to investigate the effects of CXCR7 on the proportion of immune cells and fibrosis in CP/CPPS. Western blotting, immunohistochemical staining and Immunofluorescence, flow cytometry, and masson staining were used to study the possible regulatory mechanisms. CXCR7 agonists can significantly reduce pain and prostatic inflammation, and in vivo flow studies have shown that they affect the TH17/Treg cell ratio. To elucidate the potential mechanisms by which CXCR7 influences the pathogenesis of CNP, we conducted simultaneous RNA-seq and non-targeted metabolome sequencing. Our findings suggest that CXCR7 agonists alleviate fibrosis in autoimmune prostatitis by inhibiting the TGFβ/SMAD pathway. This study provides a valuable immunological basis for CNP to intervene CP/CPPS therapy with CXCR7 as the target.
Neuropsychiatric and Laboratory Outcomes of Hepatitis C Treatment in an Early-Treated HIV Cohort in Thailand
Authors: Ocampo Ferron F. , Sacdalan Carlo , Pinyakorn Suteeraporn , Paudel Misti , Wansom Tanyaporn , Poltubtim Nathornsorn , Sriplienc Somchai , Phanuphak Nittaya , Paul Robert , Hsu Denise , Colby Donn , Trautmann Lydie , Spudich Serena , Chan Phillip 
Published: April 2024

Abstract

Background
Hepatitis C virus (HCV) coinfection may further compromise immunological and cognitive function in people with HIV (PWH). This study compared laboratory and neuropsychiatric measures across the periods of HCV seroconversion and direct-acting antiviral (DAA) therapy with sustained virologic response (SVR) among PWH who initiated antiretroviral therapy (ART) during acute HIV infection (AHI) and acquired HCV after 24 weeks of ART.
Methods
Participants from the RV254 AHI cohort underwent paired laboratory and neuropsychiatric assessments during regular follow-up. The former included measurements of CD4 + and CD8 + T-cell counts, HIV RNA, liver enzymes, and lipid profiles. The latter included the Patient Health Questionnaire-9 (PHQ-9), Distress Thermometer (DT), and a 4-test cognitive battery that evaluated psychomotor speed, executive function, fine motor speed and dexterity. The raw scores in the battery were standardized and averaged to create an overall performance (NPZ-4) score. Parameters of HCV-coinfected participants were compared across HCV seroconversion and DAA treatment groups.
Results
Between 2009 and 2022, 79 of 703 RV254 participants acquired HCV after ≥ 24 weeks of ART; 53 received DAA, and 50 (94%) achieved SVR. All participants were Thai males (median age: 30 years); 34 (68%) denied past intravenous drug use, and 41 (82%) had a history of other sexually transmitted infections during follow-up. Following SVR, aspartate transferase (AST) and alanine transaminase (ALT) decreased (p < 0.001), while total cholesterol, low-density lipoprotein, and triglycerides increased (p < 0.01). The median CD4+/CD8 + ratio increased from 0.91 to 0.97 (p = 0.012). NPZ-4 improved from 0.75 to 0.91 (p = 0.004). The median DT score increased from 1.7 to 2.7 (p = 0.045), but the PHQ-9 score remained unchanged.
Conclusion
HCV coinfection is common in this group of high-risk PWH, highlighting the need for regular screening, early diagnosis, and treatment. There was a modest improvement in the CD4+/CD8 + T-cell ratio and cognitive performance after DAA therapy in patients who achieved SVR. Future studies should examine potential neuropsychiatric impacts during early HCV infection as well as the longer-term neuropsychiatric outcomes after DAA treatment with SVR.
An improved robust modeling of multimodal for heavy tail data
Authors: Wu Weisan 
Published: April 2024

Abstract
People often use finite mixing models to fit data with complex structures, but when faced with heavy tail data, the prediction accuracy is often inaccurate or the model component number is given incorrectly. In this paper, we design a semi-supervised mixture skew t distribution model for data with heavy tail structure, which can give ideal prediction accuracy for some data with labels and others without labels. Our model is more robust than the skew t distribution model, and we apply Monte Carlo sampling technique to the EM algorithm to solve the problem of expensive sampling. Finally, we give the simulation results. Compared with the skew t distribution model and the hybrid Gaussian model, our model has more robust fitting effect and smaller model prediction error.
Experimental analysis of failure modes depending on different loading conditions applied on cylindrical polyamide 66 gears
Authors: Hriberšek Matija , Kulovec Simon 
Published: April 2024

Abstract
Engineering plastics are increasingly used for engineering applications, such as the automotive sector, e-mobility sector, and household appliances. The use of engineering plastics is conditioned by the lack of knowledge of their material properties, especially for gears. A selection of the materials for a given gear pair has a significant impact on the mechanical and thermal response of the whole system. In this paper, steel-Polyamide 66 gear pairs were tested under various torques to define failure life and associated failure modes of the polymer gears. Additionally, to discover new knowledge on the field of tribological contact between observed gear pairs, meshing temperatures were monitored and correlated with calculated wear coefficients of Polyamide 66 material according to technical guideline VDI2736-2. The results show that gear flank wear of PA66 HT is directly proportional to the meshing temperature and torque. Thermal melting is a characteristic failure mode of the polymer gears which are exposed to higher load levels. In the middle torques, the dominant failure mode is flank fracture known as pitch point fracture. The greater impact of the gear wear mechanism occurs at lower torques where initial crack propagation starts at the pitch point and ends in the tooth root area.
Fuzzy inventory model of seasonal deteriorating products with time and price sensitive demand and holding cost under partial backlogged
Authors: Sahu A. K. , Ganesh V , Indrajitsingha S. K. 
Published: April 2024

Abstract
Demand is one of the key components of inventory modeling. Moreover, the rate of demand mostly depends upon both the time and the selling price of the product. Particularly for seasonal products like milk products and vegetables having low life time, demand depends on both production and stock. Since deterioration rate, production cost and holding-cost are uncertain in the case of seasonal products like fruits vegetable, we consider them as triangular fuzzy number. Hence in this paper, we discuss a mathematical model for deterioration of seasonal products with the demand depending upon production and selling price in crisp and fuzzy approach. In the proposed model shortages with partially backlogged is allowed. Defuzzification is done by using graded mean integration representation method. An algorithm is illustrated for the solution of problem, and for the validation of the model, a real-life numerical example is considered. Furthermore sensitivity analysis of the developed model is performed to investigate the effect of different system parameters with Mathematica 11.1 software.