bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of maturation level on normative specific-agility performance metrics and their fitness predictors in soccer players aged 11–18 years
Authors: Sellami Mohamed , Makni Emna , Moalla Wassim , Tarwneh Raghad , Elloumi Mohamed 
Published: March 2024

Abstract
Background
In sports sciences, normative data serve as standards for specific physical performance attributes, enhancing talent identification within a specific population. The aim of this study was to provide standard data for Agility-15 m, Ball-15 m tests, and skill index, considering maturation level, specifically age at peak height velocity (PHV). The study also investigated the relationship between relative performances in these tests and anthropometrics, jumping (squat jump [SJ], countermovement jump [CMJ]), and sprinting abilities (S-5 m, S-10 m, S-20 m, S-30 m) in young soccer players.

Methods
The study involved 647 soccer players aged 11–18 years, categorized into three groups: pre-PHV, circum-PHV, and post-PHV. Statistical analysis was conducted using analysis of variance and Bonferroni post hoc testing to detect variations among maturation groups, and Pearson’s correlation test to examine the relationship between factors.

Results
Agility-15 m and ball-15 m performances among maturity groups showed significant differences (p < 0.01). Significant correlations were identified in pre-PHV group, between lower limb length and Agility-15 m (r=-0.23, p < 0.05) and between height and Ball-15 m (r=-0.23, p < 0.05). In post-PHV group, there was a correlation between body fat percentage (BF %) and Agility-15 m (r = 0.17, p < 0.05) and Ball-15 m (r = 0.21, p < 0.05). In all maturity groups, there were significant correlations between agility and sprint tests (S-5 m, S-10 m, S-20 m, and S-30 m) and muscle power (SJ and CMJ).

Conclusion
The study revealed that both speed and lower limb power significantly influence agility in young soccer players, providing valuable insights for coaches and practitioners to create tailored training plans and interventions for different age groups and maturity levels.
Comprehensive study of thunderstorm indices threshold favorable for thunderstorms during monsoon season using WRF–ARW model and ERA5 over India
Authors: Mondal Unashish , Kumar Anish , Panda S. K. , Sharma Devesh , Das Someshwar 
Published: March 2024

Abstract
Introduction
The current research investigates into the application of various thunderstorm indices to predict severe thunderstorm occurrences during the monsoon season across four distinct regions in India. Methods: The study assesses the prediction model’s efficacy using various skill scores and the Weather Research and Forecasting (WRF) model has been integrated for 30 h with double moment microphysics scheme NSSL-17 which accurately reproduces vertical and meteorological measures.

Objective
Furthermore, it investigates fifteen thunderstorm indices derived from the ERA5 dataset to identify the most effective index for forecasting severe thunderstorms.

Results
The results indicate that combining thunderstorm indices with skill scores, such as the Heidke Skill Score and True Skill Statistic, enhances the accuracy of severe thunderstorm predictions in the Indian monsoon season. The accurate predictions rely on determining optimal thresholds for each index. The study emphasizes the importance of using multiple indices rather relying solely on single measure for predicting severe thunderstorms. Advanced indices like the Energy Helicity Index (EHI) and Supercell Composite Parameter (SCP) perform well in forecasting extreme severe thunderstorms
due to their strong reliance on wind shears. The EHI (> 1), and SCP (≥ 3.5), STP (≥ 1.2) along with low SRH at 3 km (100 m2/s2), indicated no evidence of helicity or tornado activity during the event. On the other hand, the CAPE, K Index, and VT Index demonstrate robust predictive capabilities for non-severe category thunderstorms.

Conclusions
Integrating numerous thunderstorm indices improves meteorologists’ forecasts, ensuring public safety.
Based on this work, future research can improve severe weather forecasting models’ accuracy and reliability.
Skipping breakfast and its association with sociodemographic characteristics, night eating syndrome, and sleep quality among university students in Bangladesh
Authors: Khan Md Shafiqul Islam , Paul Trisha , Al Banna Md. Hasan , Hamiduzzaman Mohammad , Tengan Cornelius , Kissi-Abrokwah Bernard , Tetteh Justice Kanor , Hossain Faria , Islam Md. Shajadul , Brazendale Keith 
Published: March 2024

Abstract
Introduction
Skipping breakfast has become more common, and it can significantly affect a person’s health, performance, mood, and other physiological and psychological factors. In Bangladesh, university students often encounter unhealthy dietary habits, which raises questions about why many university students choose to skip breakfast. The purpose of this study was to investigate the prevalence of skipping breakfast among university students in Bangladesh and explore the contributing factors.

Methods
Patuakhali Science and Technology University, Bangladesh was the location of this cross-sectional study. Breakfast consumption was measured with the single-question item, “How often do you eat breakfast?” (Almost every day, sometimes, rarely, or never). Skipping breakfast was classified as respondents selecting sometimes, rarely, or never having breakfast. Sociodemographic, behavioral, and sleep-related data were collected as key predictor variables. Multiple logistic regression models identified factors associated with skipping breakfast.

Results
The prevalence of skipping breakfast among study participants (N = 502, 51.6% female and mean age 21.31 years) was 63.5%. Female students were more likely to skip breakfast compared to male students (adjusted odds ratio, AOR = 1.65, 95% CI: 1.06–2.55). Smoker participants had a higher likelihood of skipping breakfast compared to non-smokers (AOR = 3.92, 95% CI: 1.57–9.78). Students with night eating syndrome had a higher likelihood of skipping breakfast compared to their counterparts (AOR = 1.84, 95% CI: 1.06–3.22). Students with poor sleep quality were three times more likely to skip breakfast than their counterparts (AOR = 2.95, 95% CI: 1.93–4.51). Overweight/obese students were less likely to skip breakfast compared to their counterparts (AOR = 0.40, 95% CI: 0.20–0.82).

Conclusion
This study highlights a high prevalence of skipping breakfast among university students in Bangladesh. Specifically, students who are females, smokers, poor sleepers and who have night eating syndrome are more likely to skip breakfast compared to their counterparts. These findings underscore a need for targeted interventions and educational programs to promote healthy breakfast habits. Addressing these modifiable risk factors can have a positive impact on students’ nutritional practices and their health and wellbeing.
Elevated expression of Toll-like receptor 7 and its correlation with clinical features in patients with primary Sjögren’s syndrome
Authors: Yang Huimin , Sun Chao , Wang Xin , Wang Tao , Xie Changhao , Li Zhijun 
Published: March 2024

Abstract
Background
The labial salivary glands (LSGs) are important for the diagnosis, evaluation of therapeutic efficacy, and genetic analyses of primary Sjögren’s syndrome (pSS). In autoimmune diseases, the recognition of self nucleic acids and viral RNA and DNA through endogenous Toll-like receptor(TLR) triggers the production of type I IFN and pro-inflammatory cytokines, leading to the occurrence and progression of the disease. Here, we detected the expression of TLR7 in LSGs and analyse its correlation with clinical features and serum cytokines in pSS patients.

Methods
LSGs and serum samples were obtained from 56 pSS patients and 19 non-SS patients (non-pSS patients). The expression of TLR7 in the LSGs was evaluated with immunohistochemistry. The serum levels of interferon-α (IFN-α) and interleukin-6 (IL-6) were quantified by ELISA. Laboratory parameters were measured by clinical standard laboratory techniques.

Results
TLR7-positive cells in pSS were localized in the ductal epithelial cells and lymphocytes of LSGs. The expression of TLR7 was upregulated in pSS patients compared with controls. Patients with anti-Ro52 antibody positivity showed higher TLR7 levels than those who were negative but not those with anti-Ro60 and anti-SSB. TLR7 levels were positively associated with the levels of IgG, IgA, ANA, IL-6, IFN-α and serum globulin but were not associated with IgM, C3, C4, or rheumatoid factor (RF) in serum.

Conclusion
TLR7 may be involved in the inflammatory response and the production of antibodies in pSS and plays an important role in local and systemic pSS manifestations. This research showed that TLR7 is involved in pSS pathogenesis.
Ten-year survival after resection of a huge rhabdomyosarcoma in the pericardial cavity
Authors: Kitamoto Shohei , Yamashita Yoichi , Nakagawa Sayako , Horii Taiko 
Published: March 2024

Abstract
Background
Primary malignant cardiac tumors are exceedingly rare and cardiac rhabdomyosarcoma among them is an exceptional rarity characterized by a dismal poor prognosis.

Case presentation
A 48-year-old man had suffered from a persistent cough lasting for more than 6 months and computed tomography showed a huge mass in the pericardial cavity with heterogeneous content. Following referral to our department for suspected cardiac malignancy, cardiac magnetic resonance imaging revealed a lucent layer on the boundary around the mass, suggesting the feasibility of surgical resection. A baby-head-sized mass in the pericardial cavity was entirely resected and the pathological examination confirmed a tumor as a spindle cell type rhabdomyosarcoma. The patient underwent adjuvant chemotherapy and has well survived over a decade after surgery without any sign of recurrence.

Conclusion
Radical resection with adjuvant chemotherapy may achieve a favorable outcome for patients with massive rhabdomyosarcomas inside the pericardial cavity.
Mineralocorticoid Receptor and Aldosterone: Interaction Between NR3C2 Genetic Variants, Sex, and Age in a Mixed Cohort
Authors: Heydarpour Mahyar , Parksook Wasita W , Pojoga Luminita H , Williams Gordon H , Williams Jonathan S 
Published: March 2024

Abstract

Context
Hypertension, a prevalent cardiovascular risk, often involves dysregulated aldosterone and its interaction with the mineralocorticoid receptor (MR). Experimental designs in animal models and human cohorts have demonstrated a sex and age dependency of aldosterone secretion that expands our pathophysiologic understanding.

Objective
This study explores the genetic variation of NR3C2, which encodes MR, in relation to aldosterone, considering age, sex, and race.

Methods
Incorporating 720 Caucasians and 145 Africans from the HyperPATH cohort, we investigated the impact of rs4835490, a single nucleotide risk allele variant, on aldosterone levels and vasculature.

Results
Notably, a significant association between rs4835490 and plasma aldosterone under liberal salt conditions emerged in individuals of European ancestry (P = .0002). Homozygous carriers of the risk A allele exhibited elevated plasma aldosterone levels (AA = 8.1 ± .9 vs GG = 4.9 ± .5 ng/dL). Additionally, aldosterone activation through posture (P = .025) and urinary excretion (P = .0122) showed notable associations. Moreover, genetic interactions with race, sex, and age were observed. Caucasian females under 50 years displayed higher plasma aldosterone, urine aldosterone, and posture aldosterone with the AA genotype compared to females over 50 years, suggesting a potential connection with menopausal or estrogen influences. Interestingly, such age-dependent interactions were absent in the African cohort.

Conclusion
Our study highlights the significance of the NR3C2 genetic variation and its interplay with age, sex, and race in aldosterone activation. The findings point toward an estrogen-modulating effect on MR activation, particularly in women, underlining the role of aldosterone dysregulation in hypertension development. This insight advances our comprehension of hypertension's complexities and opens avenues for personalized interventions.
Clinical Trial Registration Number: NCT03029806 (registered January 24, 2017).
Mini-Puberty, Physiological and Disordered: Consequences, and Potential for Therapeutic Replacement
Authors: Rohayem Julia , Alexander Emma C , Heger Sabine , Nordenström Anna , Howard Sasha R 
Published: March 2024

Abstract
There are 3 physiological waves of central hypothalamic-pituitary-gonadal (HPG) axis activity over the lifetime. The first occurs during fetal life, the second—termed “mini-puberty”—in the first months after birth, and the third at puberty. After adolescence, the axis remains active all through adulthood. Congenital hypogonadotropic hypogonadism (CHH) is a rare genetic disorder characterized by a deficiency in hypothalamic gonadotropin-releasing hormone (GnRH) secretion or action. In cases of severe CHH, all 3 waves of GnRH pulsatility are absent. The absence of fetal HPG axis activation manifests in around 50% of male newborns with micropenis and/or undescended testes (cryptorchidism). In these boys, the lack of the mini-puberty phase accentuates testicular immaturity. This is characterized by a low number of Sertoli cells, which are important for future reproductive capacity. Thus, absent mini-puberty will have detrimental effects on later fertility in these males. The diagnosis of CHH is often missed in infants, and even if recognized, there is no consensus on optimal therapeutic management. Here we review physiological mini-puberty and consequences of central HPG axis disorders; provide a diagnostic approach to allow for early identification of these conditions; and review current treatment options for replacement of mini-puberty in male infants with CHH. There is evidence from small case series that replacement with gonadotropins to mimic “mini-puberty” in males could have beneficial outcomes not only regarding testis descent, but also normalization of testis and penile sizes. Moreover, such therapeutic replacement regimens in disordered mini-puberty could address both reproductive and nonreproductive implications.
Novel Mutation in CYP2R1 Causing Vitamin D-Dependent Rickets Type 1b
Authors: Menon Jayakrishnan C , Kumari Archana , Sajjan Shruti M , Dabadghao Preeti 
Published: March 2024

Abstract
Monogenic forms of rickets are being increasingly recognized. However, vitamin D-dependent rickets 1b (VDDR1b) due to CYP2R1 gene mutation is exceedingly rare. We report a 4.5-year-old girl and her younger sibling who presented with clinical, radiological, and biochemical features suggestive of nutritional rickets that did not resolve despite repeated therapeutic doses of vitamin D3. This led to evaluation for resistant rickets, which revealed a novel homozygous CYP2R1 c.50_51insTCGGCGGCGC; p.Leu18ArgfsTer79 variant in the affected siblings. The children were treated with oral calcium and cholecalciferol, dose titrated to maintain serum alkaline phosphatase, 25 hydroxy vitamin D, and parathyroid hormone levels in the normal range, with good clinical and radiological response. This case highlights the importance of genetic evaluation in patients with suspected nutritional rickets who have a family history of similar illness and require higher than usual doses of vitamin D for healing or relapse on stopping treatment. To the best of our knowledge this is the first case of VDDR1b reported from Asia.
The Hidden Source of Testosterone Hypersecretion in a Female—A 30-Year Journey
Authors: Yang Almira J , Munir Iqbal 
Published: March 2024

Abstract
A Sertoli-Leydig cell tumor (SLCT) is a rare ovarian tumor that often excessively secretes testosterone and its precursor, leading to virilization in females. We present a case of a female patient with persistent, severe hyperandrogenism. Our patient had a history of left oophorectomy due to an ectopic pregnancy and initially presented with amenorrhea at the age of 30. Biochemical evaluations suggested ovarian hyperandrogenism. Despite the absence of an ovarian mass, she underwent a right oophorectomy and remained hyperandrogenic postoperatively. When she established care with our endocrinology clinic at the age of 58, she had more virilizing features and total testosterone levels ranging from 10.1 to 12.0 nmol/L (292-346 ng/dL; normal reference range for women: 0.07-1.56 nmol/L; 2-45 ng/dL). While biochemical evaluations were consistent with tumorous ovarian hyperandrogenism, ultrasound and computed tomography again failed to identify the source. Finally, an 18F-fluorodeoxyglucose-positron emission tomography/computed tomography revealed a mass in the left adnexa, and she underwent removal of the mass. The final pathology confirmed SLCT. The case highlights that SLCT may be small and slow-growing and not readily visible on conventional imaging modalities.
Ventilatory Responses to Exercise by Age, Sex, and Health Status
Authors: Haverkamp Hans Christian , Balmain Bryce N. 
Published: March 2024

Abstract
An understanding of the normal pulmonary responses to incremental exercise is requisite for appropriate interpretation of findings from clinical exercise testing. The purpose of this review is to provide concrete information to aid the interpretation of the exercise ventilatory response in both healthy and diseased populations. We begin with an overview of the normal exercise ventilatory response to incremental exercise in the healthy, normally trained young-to-middle aged adult male. The exercise ventilatory responses in two nonpatient populations (females, elderly) are then juxtaposed with the responses in healthy males. The review concludes with overviews of the exercise ventilatory responses in four patient populations (obesity, chronic obstructive pulmonary disease, asthma, congestive heart failure). Again, we use the normal response in healthy adults as the framework for interpreting the responses in the clinical groups. For each healthy and clinical population, recent, impactful research findings will be presented.
Planning Courses for Student Success at the American College of Greece
Authors: Christou Ioannis T. , Vagianou Evgenia , Vardoulias George 
Published: March 2024

We are concerned with the personalized student course plan (PSCP) problem of optimizing the plan of courses students at the American College of Greece will need to take to complete their studies. We model the constraints set forth by the institution so that we guarantee the validity of all produced plans. We formulate several different objectives to optimize the resulting plan, including the fastest completion time, course difficulty balance, and maximization of the expected student grade point average given the student’s performance in past courses. All resulting problems are mixed-integer linear programming problems with a number of binary variables, that is, the max number of terms times the number of courses available for the student to take. The resulting mathematical programming problem is solvable in less than 10 seconds on a modern commercial off-the-shelf PC, whereas the manual process used to take more than one hour of advising time for every student and, as measured by the objectives set forth, resulted in suboptimal schedules. History: This paper was refereed.
Learning to Order for Inventory Systems with Lost Sales and Uncertain Supplies
Authors: Chen Boxiao , Jiang Jiashuo , Zhang Jiawei , Zhou Zhengyuan 
Published: March 2024

We consider a stochastic lost-sales inventory control system with lead time L over a planning horizon T. Supply is uncertain, and it is a function of the order quantity (because of random yield/capacity, etc.). We aim to minimize the T-period cost, a problem that is known to be computationally intractable even under known distributions of demand and supply. In this paper, we assume that both the demand and supply distributions are unknown and develop a computationally efficient online learning algorithm. We show that our algorithm achieves a regret (i.e., the performance gap between the cost of our algorithm and that of an optimal policy over T periods) of [Formula: see text] when [Formula: see text]. We do so by (1) showing that our algorithm’s cost is higher by at most [Formula: see text] for any [Formula: see text] compared with an optimal constant-order policy under complete information (a widely used algorithm) and (2) leveraging the latter’s known performance guarantee from the existing literature. To the best of our knowledge, a finite sample [Formula: see text] (and polynomial in L) regret bound when benchmarked against an optimal policy is not known before in the online inventory control literature. A key challenge in this learning problem is that both demand and supply data can be censored; hence, only truncated values are observable. We circumvent this challenge by showing that the data generated under an order quantity q2 allow us to simulate the performance of not only q2 but also, q1 for all [Formula: see text], a key observation to obtain sufficient information even under data censoring. By establishing a high-probability coupling argument, we are able to evaluate and compare the performance of different order policies at their steady state within a finite time horizon. Because the problem lacks convexity, commonly used learning algorithms, such as stochastic gradient decent and bisection, cannot be applied, and instead, we develop an active elimination method that adaptively rules out suboptimal solutions. This paper was accepted by Victor Martínez-de-Albéniz, operations management. Funding: This work is supported by the National Science Foundation [Grant CCF-2312205]. Z. Zhou also acknowledges the New York University’s 2024 Center for Global Economy and Business [Faculty Research Grant] and New York University [Research Catalyst Prize]. Supplemental Material: The online appendix is available at https://doi.org/10.1287/mnsc.2022.02476 .