bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of two glass eye (Jatim) beads unearthed from the Northern Wei tomb complex in Dongxin, Datong
Authors: Jia Yanqin , Cui Jianfeng , Cao Chenming 
Published: March 2024

Abstract

This study analyzed two glass eye beads discovered in an ancient tomb complex at Dongxin Furniture Square in Datong, Shanxi Province in China. The tomb complex was dated to the Northern Wei Dynasty (398–494 AD), when Datong was known as Pingcheng. We used scanning electron microscopy (SEM) and energy dispersive spectrometry (EDS) as well as a 3D microscope system with ultra-depth of field to conduct non-destructive tests on the beads. We examined the beads’ manufacturing techniques, including matrices, eye patterns, and bead holes. The composition analysis revealed that both beads belonged to the Na2O–CaO–SiO2 glass system. The bases were colored using Co2+, whereas the white, red, and yellow colors of the eye patterns were achieved using SnO2, Cu2O, or Cu0, and PbSnO3, respectively. These findings indicated that both objects were Jatim beads originating in the Kingdom of Java in Southeast Asia. This study provides valuable insights into ancient trade routes between different regions and offers reliable scientific evidence of the glass trade and technical exchanges in ancient times.
The “Integration Of Sports And Medicine” To Promote The Change Of Adolescent Sports Behavior: Application Based On TTM
Authors: Zhang Tingran , Yang Yi , Liu Shiqi , Wang Kun , Liu Hengxu , Luo Jiong 
Published: March 2024

Abstract
Background Currently, sports related sudden death accidents have occurred frequently among Chinese teenagers due to insufficient physical exercise, resulting in a decline in physical fitness. Therefore, in the context of the "Healthy China 2030" strategic outline, it is urgent to solve the physical health problems of teenagers and promote their lifelong fitness habits.Method Through collecting relevant research documents and based on the transtheoretical model (TTM), this study focuses on the current situation, impact path, coping strategies, processes, and other issues of Chinese teenagers' fitness behavior, and constructs a model framework of "integration of sports and medicine" to promote the formation of teenagers' sports behavior.Results The study pointed out that the development of adolescent sports behavior requires schools, communities, and medical and health institutions to adopt integrated intervention measures, with "3 (sports knowledge and concepts, healthy lifestyle and behavior, sports skills training) + 6 (safety and first aid, scientific health concept, health information, infectious disease prevention, chronic disease prevention, basic medical treatment)" as the main content of the health fitness evaluation system, Only by designing a diversified intervention plan that conforms to the sports stage of each teenager can we successfully promote individual sports behavior to develop in a regular direction.Conclusions Guided by a cross theoretical model and starting from biomedical and non medical health interventions, the "integration of sports and medicine" intervention model can effectively integrate the health resources of adolescents, promote the development of extracurricular sports activities in schools, and improve their fitness behavior.
Compositional uniqueness and species contribution to beta diversity of aquatic macrophyte metacommunities from coastal wetlands
Authors: Rossano Claudio , Schneck Fabiana 
Published: March 2024

Abstract

The partitioning of overall beta diversity into local contributions (LCBD) and species contributions (SCBD) has enhanced the understanding of the organization of metacommunities. Here, we evaluated LCBD and SCBD of aquatic macrophyte metacomunnities from 29 subtropical coastal wetlands, covering an extension of 640 km, in southern Brazil. Furthermore, we assessed the environmental uniqueness, considering both the physical and chemical variables of water in wetlands, as well as climatic variables. We assessed the environmental and spatial correlates of LCBD and the environmental correlates of SCBD. We expected that (i) more unique communities would be found in environmentally more unique wetlands; (ii) the compositional uniqueness would also be related to climatic variables that determine the hydrological changes in wetlands; (iii) the contribution of emergent species to beta diversity would be lower than of floating and submerged species. The compositional uniqueness did not present a clear spatial structure, being positively related to uniqueness in water chemistry and negatively to the mean air temperature during the driest quarter. The species contribution to beta diversity was higher for floating species than for emergent ones. Moreover, SCBD correlated to climatic variables and presented a positive relationship with site occupation, suggesting that more frequent species in terms of site occurrence" contribute most to beta diversity. Our results show the importance of local environmental and broader climatic predictors in determining the compositional uniqueness of macrophyte communities and the species contributions to overall beta diversity in the coastal wetlands of southern Brazil.
The clinical efficacy comparison of tibial cortex transverse transport and platelet-rich plasma treatment of severe diabetic foot ulcers
Authors: Zhen Puxiang , Su Hongjie , Yang Sijie , Chen Xiang , Dong Shunan , Lin Zhanming , Liu Sainan 
Published: March 2024

Abstract
Objective The comparison analysis uses the clinical efficacy of the tibial cortex transverse transport and the enrichment of platelet plasma to treat severe diabetic foot ulcers and the effects of vascular endothelial cell vitality.Methods Retrospective analysis was performed on two groups of patients treated at our hospital from July 2019 to June 2022. One group received tibial cortex transverse transport (TTT) and the other received platelet-rich plasma (PRP). Both groups had Wagner level 3 or greater. We compared clinical efficacy, wound healing, arterial and posterior tibial arterial blood flow rates, and horizontal SDF-1 levels in peripheral blood between the groups.Results TTT group had higher healing rates at 1.5-year follow-up than the PRP group (96.67% [29/30] versus 80% [24/30], p < 0.05). The healing time of the TTT group was shorter than the control group (3.02 ± 0.84 versus 6.04 ± 0.85 months, p = 0.000). The amputation rate (3.33% [1/30] versus 20% [6/30], p < 0.05) and recurrence rate (6.67% [2/30] versus 26.67% [8/30], p < 0.05) of the TTT group were lower than the control group. One month after surgery and last follow-up, the SDF-1 concentration in the perimeter of the TTT group was significantly higher than the PRP group (375.36 ± 13.52 versus 251.93 ± 9.82 pg/ml, p = 0.000; 256.62 ± 13.19 versus 239.95 ± 10.78 pg/ml, p = 0.000). The average blood flow speed in the arterial artery of the TTT group was faster than the PRP group (68.93 ± 2.69 versus 58.14 ± 2.48 cm/s, p = 0.000) 4 weeks postoperatively and (55.68 ± 3.43 versus 46.07 ± 3.02 cm/s, p = 0.000) last follow-up.Conclusion The findings showed that TTT had better efficacy than PRP in treating severe diabetic foot ulcers. It could effectively stimulate SDF-1 expression, promote vascular hyperplasia, and accelerate wound healing.
Association between serum total indoxyl sulfate, intraperitoneal inflammation, and peritoneal dialysis technique failure: a 3-year prospective cohort study
Authors: Stepanova Natalia , Driianska Victoria , Korol Lesya , Snisar Lyudmyla 
Published: March 2024

Abstract

Background
The impact of protein-bound uremic toxins, specifically indoxyl sulfate (IS) on peritoneal dialysis (PD) complications remains controversial. This study aimed to explore the link between serum total IS (tIS) levels, proinflammatory cytokines in serum and peritoneal dialysate effluent (PDE), and PD techniques survival.
Methods
In this prospective cohort study, 84 patients were followed up for three years and analyzed. Stratification into Low tIS (< 22.6 µmol/L) and High tIS (≥ 22.6 µmol/L) groups was based on the median serum tIS concentration. Logistic regression, Kaplan-Meier, receiving operation characteristic, and Cox regression analyses assessed associations between tIS levels, cytokine concentrations (IL-6, MCP-1, TNF-α), and PD technique failure.
Results
The High tIS group exhibited poor clinical characteristics compared with the Low-tIS group. Elevated tIS levels significantly correlated with higher PDE cytokine levels, without a corresponding rise in serum cytokine levels. Serum tIS levels ≥ 50 µmol/L predicted PD technique failure with 70.4% sensitivity and 87.9% specificity (p < 0.0001). The association between high tIS levels and PD technique failure persisted after adjusting for relevant factors (HR 3.14, 95% CI 1.13; 8.72), but the inclusion of PDE cytokines in the model diminished this association (HR 2.18, 95% CI 0.93; 5.14).
Conclusion
Our findings underscore the link between elevated tIS levels, peritoneal inflammation, and an increased risk of PD technique failure. Monitoring tIS levels in PD patients may be clinically relevant for risk assessment and personalized management, potentially enhancing long-term PD outcomes. Future research could explore interventions targeting tIS reduction to alleviate peritoneal inflammation and improve PD prognosis.
Area of residual tumor measurement after preoperative chemotherapy as an objective and quantitative method for predicting prognosis of gastric cancer: a single-center retrospective study
Authors: Nagata Hiromi , Sakashita Shingo , Kojima Motohiro , Taki Tetsuro , Kuwata Takeshi , Yura Masahiro , Kinoshita Takahiro , Shitara Kohei , Ishii Genichiro , Sakamoto Naoya 
Published: March 2024

Abstract

Purpose
Anticancer drug therapy plays an indispensable role in the treatment of gastric cancer (GC), and pathologists usually evaluate the effectiveness of therapy using surgically resected specimens. Measurement of the area of the residual tumor (ART) has been reported to be a quantitative and useful method for prognosticating several cancers. Therefore, this study aimed to evaluate the prognostic utility of ART in predicting the outcomes of patients with GC after preoperative chemotherapy.
Methods
In this single-center retrospective study, we examined the relationship between ART and survival outcomes. We included 92 patients who underwent preoperative chemotherapy followed by radical gastrectomy for GC. Digital images were used to measure the area of residual cancer cells in the largest slice of the tumor of each patient's surgical specimen. We subclassified the patients into two groups: ART-0 (ART < 0.1 mm2, excluding carcinoma in situ) and non-ART-0, and compared their clinicopathological factors and prognosis.
Results
Significant differences were noted in recurrence-free survival (RFS) and overall survival between ART-0 and non-ART-0. Multivariate analysis revealed that non-ART-0 and ypN-positive status were independent poor prognostic factors for RFS. Subgroup analysis with ypN and ART showed that the patient groups with ypN-negative and ART-0 had a significantly better prognosis (P < 0.001) than the other groups.
Conclusion
The ART-based assessment is a promising quantitative tool for predicting the prognosis of patients with GC who undergo preoperative chemotherapy and radical gastrectomy.
Exploring the Relationship Between Tuberculosis and Gut Microbiota: A Multi-Omics Approach
Authors: Zhang Chunying , Li Mengjiao , Lyu Mengyuan , Zhou Yanbing , Wang Yili , You Liting , Liu Tangyuheng , Peng Wu , Bai Hao , Zhao Zhenzhen , Ying Binwu 
Published: March 2024

Abstract
Background: A number of unanswered questions remain regarding the relationship between tuberculosis (TB) and our gut microbiota, which consists of microbial life within our bodies. Multi-omics is an effective strategy to reveal the mechanism of disease, including tuberculosis, but there are few reports on TB by using multi-omics.
Methods: In this study, we integrated omics analysis to investigate the altered gut microbiota and fecal metabolomic profiles in TB patients using 16S rDNA gene sequencing and liquid chromatography-mass spectrometry (LC-MS). A total of 29 untreated TB patients and 29 health controls (HCs) were recruited in this study. we sequenced the 16S rDNA V3-V4 variable regions to obtain the intestinal microbiota and evaluated the diagnostic ability for TB of the differential intestinal microbiota. Then the fecal metabolic profiles were investigated by LC-MS.
Results: the intestinal microbiota in TB patients was significantly changed compared with that in HCs. Nine differential intestinal microbiota (genus)，including Akkermansia, Erysipelotrichaceae, Clostridium_innocuum_group, Eubacterium_hallii_group, Eubacterium_ventriosum_group, Lachnospira, Ruminococcus_2, Roseburia and Blautia, can distinct TB patients from HCs with high accuracy (sensitivity 79.3%, specificity 89.7%). A total of 33 significantly differential-metabolites in TB patients were identified by the metabolomics analysis, and the indole-3-propionic acid (IPA) enriched in TB patients showed the strongest correlation with intestinal microbiota.
Conclusions: The gut microbiota composition and metabolic profiles significant changed in TB patients in TB patients, which can be used as potential preventive and therapeutic targets for TB, and IPA enriched in TB patients may play an important role in the pathogenesis of TB.
Sodium Alginate Carboxymethyl Cellulose Composite Hydrogel beads for Oral Drug Delivery
Authors: Ullah Hidayat , Akram Muhammad , Khan Haiqa , Irfan Muhammad , Hassan Ayaz 
Published: March 2024

Abstract
Hydrogels based on biopolymers demonstrate great potential for drug delivery applications because they are not only biocompatible but also various release profiles of therapeutic agent can be achieved by altering polymeric matrix. Particularly, oral drug delivery is the most preferred and convenient route for drug administration showing high patient compliance. The aim of this study is to synthesize composite hydrogel beads and examine their potential for oral administration using paracetamol as a model drug. Therefore, native sodium alginate of different viscosity and composite hydrogel beads based on sodium alginate and carboxy methyl cellulose of different polymer concentrations were synthesized using calcium chloride dihydrate as a crosslinking agent. These hydrogels beads were then characterized by Fourier-transform infrared spectroscopy, Differential scanning calorimetry and X-ray crystallography. The surface morphology of prepared hydrogel beads was visualized by scanning electron microscope. Their average weight and dimensions were measured and their swelling behavior at different pH (distilled water and PBS pH 7 and 5.8 respectively) were analyzed. It was shown that the swelling of the synthesized hydrogels was affected by the variation in pH. Moreover, the amount of drug loading in sodium alginate was lower than the amount loaded in composite hydrogel beads. Furthermore, drug release studies of containing hydrogels showed that drug release rate found to be high in composite hydrogels (715 ug per bead) as compared to native hydrogels (439 ug per bead). These hydrogels can be suitable for oral administration following further in vivo studies.
Physical frailty, preserved ratio impaired spirometry and the incidence of chronic obstructive pulmonary disease：a population-based cohort study
Authors: Liu Chao , Xiong Hui , Han Xia , Lv Yanling , Wang Decai , Hu Jiannan , Li Ziling , Ma Xinyue , Zhu Yunfei , Chen Liangkai , Xu Shuyun 
Published: March 2024

Abstract
Background
Patients with COPD are prone to be accompanied by frailty, whether frailty poses a burden of developing COPD in in the general population remains unknown. The purpose of this study is to explore whether prefrailty and frailty increase the risk of COPD, and whether the risk of COPD is significantly increased in the preserved ratio impaired spirometry population with frailty.
Methods
We included 412,351 adults without COPD at baseline in UK Biobank study. Frailty phenotypes were assessed using five components (weight loss, exhaustion, low physical activity, slow gait speed, and low grip strength). Cox proportional hazard regression models were used to analyze the association between frailty and the incidence of COPD, as well as the impact of frailty in conjunction with preserved ratio impaired spirometry on the incidence of COPD.
Results
Among all participants, 243,777 (59.1%) were nonfrailty, 155,114 (37.6%) were prefrailty, and 13,460 (3.3%) were frailty. During a median follow-up of 13.5 years, 10,695 COPD cases were recorded. In the multivariable-adjusted model, frailty and prefrailty significantly increased the risk of COPD (HR 2.22, 95%CI: [2.07, 2.38] for frailty and HR 1.45, 95%CI: [1.39, 1.51] for prefrailty). The hazard ratio for the incidence of COPD in individuals with both frailty and preserved ratio impaired spirometry was 4.34 (95%CI: 3.69, 5.12).
Conclusions
Prefrailty and frailty were associated with an increased risk of COPD. Such association was independent of socioeconomic factors, lifestyles, morbidities, and genetic susceptibility, and modified by preserved ratio impaired spirometry status.
A meshless and binless approach to compute statistics in 3D Ensemble PTV
Authors: Ratz Manuel , Mendez Miguel A. 
Published: March 2024

Abstract

We propose a method to obtain super-resolution of turbulent statistics for three-dimensional ensemble particle tracking velocimetry (EPTV). The method is "meshless" because it does not require the definition of a grid for computing derivatives, and it is "binless" because it does not require the definition of bins to compute local statistics. The method combines the constrained radial basis function (RBF) formalism introduced Sperotto et al. (Meas Sci Technol, 33:094005, 2022) with a kernel estimate approach for the ensemble averaging of the RBF regressions. The computational cost for the RBF regression is alleviated using the partition of unity method (PUM). Three test cases are considered: (1) a 1D illustrative problem on a Gaussian process, (2) a 3D synthetic test case reproducing a 3D jet-like flow, and (3) an experimental dataset collected for an underwater jet flow at Re = 6750 using a four-camera 3D PTV system. For each test case, the method performances are compared to traditional binning approaches such as Gaussian weighting (Agüí and Jiménez, JFM, 185:447-468, 1987), local polynomial fitting (Agüera et al, Meas Sci Technol, 27:124011, 2016), as well as a binned version of the RBF statistics.
A new 2D-HLSM-CECP hyperchaotic map and its application on image encryption using fractal-based permutation and cross coupled diffusion
Authors: Zhang Zeyu , Zhang Wenqiang , Wang Mingxu , Ren Na , Wang Liming , Zhang Jiao , Zhao Yue , Wang Hongjiang 
Published: March 2024

Abstract
To enhance the security of the image encryption algorithm (IEA) based on chaotic system, this paper firstly introduced a new hyperchaotic map called two-dimensional hyperchaotic Logistic-Sine map coupled exponential control parameter (2D-HLSM-CECP) coupled with the two-dimensional Logistic map and the Sine map, which displays better hyperchaotic behavior and randomness than some existing chaotic systems. Then, this work further represents a novel IEA based on 2D-HLSM-CECP, fractal sorting matrix and cross coupled diffusion. The new 2D-HLSM-CECP is used to generate two chaotic sequences, which played a significant role in the whole encryption and decryption part. All pixels of the plain-image are confused and diffused based on fractal sorting matrix and global cross coupled operation respectively. Theoretical analysis and simulation results demonstrate that the 2D-HLSM-CECP-IEA has splendid achievement in well-known security indicators. Thus, the 2D-HLSM-CECP-IEA is highly secure as a conclusion.
Comparative Study on Seismic Behavior of Regularand Irregular Building in Sloping Ground
Authors: Khand Parash Kunwar , Poudel Prakash , Poudel Amit 
Published: March 2024

Abstract
Building in steep and seismically active areas creates distinct challenges requiring an in-depth understanding of seismic irregularities and behavior. This study examines the seismic performance of buildings on sloping terrain, with a focus on areas such as Nepal. It takes into account a variety of configurations, including Step Back, Step Back Set Back, Split Foundation, and Split Foundation Set Back. Slope stability factors are assessed and soil-structure interaction (SSI) dynamics are integrated into the analysis of regular and irregular structures, including Plan Regular and Plan Irregular designs. The study uses ETABS v16.2.1 for non-linear time history analysis in order to investigate the impact of irregularities, the influence of SSI, and seismic responses. The outcomes show that flexible bases influence lateral movement and time periods by reducing base shear. The study intends to provide essential information for future seismic-resistant slopeside structures, directing resilient construction practices in challenging terrains.
Assessment of wheat chlorophyll content based on an improved whale optimization algorithm
Authors: Song Yufei , Meng Xi , Zhou Yi , Li Yan , Liu Zhiguo 
Published: March 2024

Abstract

The analysis of leaf information derived from digitized leaf images enables the efficient, noninvasive, and real-time estimation of chlorophyll content in a cost-effective manner, facilitating high-throughput assessment. In the present study, leaf color information was captured in various color spaces, such as RGB, HSI and L*a*b*. The entropy weighting method has been employed to estimate the chlorophyll content measured via Soil Plant Analysis Development (SPAD) chlorophyll meter values. The a*, R-B-G, R-G, (a*+b*)/L, a*/b*, (R-G)/(R + G + B), (R-B)/(R + B), H/S and (R-G)/(R + G) exhibited strong correlations (R2 = 0.745) with the SPAD values. Furthermore, the swarm intelligence algorithm, viz. the improved whale optimization algorithm (IMWOA), was applied to assess wheat leaf chlorophyll content by selected image color indices. The experimental results indicate that the IMWOA can achieve the most accurate estimation, obtaining an R2 of 0.77 and a root mean square error (RMSE) of 2.16.