bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cancer of the male breast: The Turkish experience
Authors: Engin Kayihan , Unsal Mustafa 
Published: February 2007

AbstractTwenty‐six patients with male breast cancer who were admitted to the Center of Oncology and Nuclear Medicine, Istanbul, Turkey, between 1980 and 1988, were analyzed retrospectively. Median age was 60 years. Most lesions were infiltrating ductal carcinomas (92%). Of 26 lesions, 9 were staged as stage II (35%), 14 as stage III (54%), and 3 as stage IV (11%). All but five patients underwent unilateral mastectomy (81%). Postoperative treatment consisted of radiation therapy combined with chemotherapy in 11 patients (42%), chemotherapy with or without hormonal therapy in 4 (15%), radiation therapy alone in 10 (38%). Radiation therapy was delivered for a mean total radiation dose of 52 ± 2 Gy (range 30–60 Gy). Chemotherapy consisted of cyclophosphamide, methotrexate and 5‐fluorouracil (CMF) in most patients (60%). FAC regimen (5‐fluorouracil, Adriamycin, and cyclophosphamide) was given to 6 patients (40%). Six patients were known to have died of breast cancer during follow‐up (23%). Fourteen patients were NED (no evidence of disease) at last follow‐up (54%). Overall actuarial 5‐year survival was calculated to be 37%, and median actuarial survival was 46.6 months. Actuarial 5‐year disease‐free survival was 27%, and median actuarial disease‐free survival was 47.1 months. Only one patient had a local recurrence, and eight patients had 13 distant metastases (31%). Age (P = 0.023), tumor stage (P = 0.055) and nodal status (P = 0.013) were the most significant prognostic factors correlated with the overall survival. © 1993 Wiley‐Liss, Inc.
Total pelvic exenteration with preservation of fecal continence
Authors: Brodsky Jeffrey T. , Sloane Bruce B. , Khanna Om P. 
Published: February 2007

AbstractTotal pelvic exenteration may be required in the management of locally advanced or recurrent pelvic malignancy. Although prolonged survival may be achieved, the morbidity of this procedure is substantial. Many of the complications associated with total pelvic exenteration are related to the perineal wound, the necessity for two cutaneous stomas, and the creation of a empty pelvis that often has been previously irradiated. In selected cases, perineal preservation with restoration of coloanal continuity may significantly reduce postoperative morbidity. We report four cases of recurrent pelvic malignancy treated by total pelvic exenteration with preservation of fecal continence. © 1993 Wiley‐Liss, Inc.
A study from South India on the association between the papilloma virus and carcinoma of the penis
Authors: Kini Usha , Thomas John A. , Shariff Shameem 
Published: February 2007

AbstractSpecimens from 39 cases of squamous cell carcinoma of the penis were treated for the papilloma virus using the bovine papilloma virus antibody and the peroxidase—antiperoxidase technique. All 39 cases showed a viral antigen situated intranuclearly, intracytoplasmically or both intranuclearly and intracytoplasmically. No correlation could be seen between the presence of viral antigen and age of patient, duration of lesion, cell morphology and histological grade. The adjacent mucosa and skin were used as controls and showed no viral antigen. The inflammatory infiltrate was dense and predominantly “T” lymphocyte in type. © 1993 Wiley‐Liss, Inc.
Ethanol injection therapy in RBT—1 carcinoma of the rat liver evokes enhancement of metastasis
Authors: Ikeda Yasuharu , Matsumata Takashi , Adachi Eisuke , Nishizaki Takashi , Sugimachi Keizo 
Published: February 2007

AbstractTo search for possible untoward effects of ethanol injection into a malignant tumor, a series of experiments was carried out using the model of RBT‐1 carcinoma. Ten days after the inoculation of RBT‐1 carcinoma into the rat liver, the animals were separated into three groups: Group A, ethanol injection during relaparotomy; group B, physiological saline injection during relaparotomy; and group C, relaparotomy alone without ethanol injection. Twenty minutes after these procedures, the tumor was surgically removed and histologically examined. The incidence of vascular permeation of liver tumor cells into the hepatic vein was significantly higher in groups A and B (P < 0.05). On the 10th day after relaparotomy, the number of metastatic nodules in the lungs was significantly increased in groups A and B, compared to the findings in group C (P < 0.05). Regarding the survival time of rats after relaparotomy, there was no statistically significant difference among the three groups. These results are taken to mean that ethanol injection into a tumor may enhance metastasis. © 1993 Wiley‐Liss, Inc.
Malignant pleural mesothelioma: A clinicopathological study
Authors: Qua Josefino C. , Rao UMA N. M. , Takita Hiroshi 
Published: February 2007

AbstractIn this paper the results of a retrospective review of 58 patients with malignant pleural mesothelioma treated at our Institute are reported. There were 50 males and 8 females; the mean age was 56.3 years (range: 13–77). History of asbestos exposure was ascertained in 25 patients (43%). The most common finding in chest X‐ray was pleural effusion which was seen in 47/58 patients on presentation. The cytological examination of pleural effusion was most of the time nondiagnostic. Pleural biopsy was needed for the correct diagnosis. Pathologically, 26 patients (44.8%) had epithelial type, 24 patients (41.4%) had mixed type, and 8 patients (13.8%) had fibrous or sarcomatous type of pleural mesothelioma. Most of the patients on presentation had Stage I disease by Butchart's classification. The overall survival time ranged from 1 month to as long as 17 years with a median of 12.5 months. The mean survival of patients who received nonsurgical therapies was 7–13.4 months. Thirteen patients were treated surgically: three patients survived over 5 years, but the median survival was 15 months. Six patients received no treatment, and the median survival was seven months. © 1993 Wiley‐Liss, Inc.
Flow cytometric DNA analysis does not predict the radiochemoresponsiveness of esophageal cancer
Authors: Segalin Andrea , Ruol Alberto , Panozzo Marina , Bonavina Luigi , Bianchi Luigi Chieco , Peracchia Alberto 
Published: February 2007

AbstractThe relationship between the DNA pattern and the responsiveness to chemotherapy or chemoradiotherapy has been evaluated in 30 patients with squamous cell carcinoma of the esophagus. In 24 patients polychemotherapy with cisplatin (100 mg/m2 on day 1) and 5‐fluorouracil (1,000 mg/m2/ 24 h, continuous infusion of 120 h) every 3 weeks, was performed. Six other patients received chemoradiotherapy with cisplatin 80 mg/m2 on day 1 and 18.5 Gy (split course). Before treatment, at least three endoscopic biopsies were taken from each tumor and frozen at −85°C. Five patients were excluded from the evaluation, three because of interrupted treatment and two due to unsuitable biopsy material obtained endoscopically. The response rate to the cytoreductive treatment was 40% (10/25). DNA content was analyzed with flow cytometry. Out of 25 evaluable patients, a diploid and aneuploid tumor was present in 8 (32.0%) and 17 (68.0%) patients, respectively. According to the DNA pattern, a major response was observed in 4 of 8 patients with a diploid tumor and in 6 of 17 patients with an aneuploid tumor (P = 0.5). No relationship between the percentage of cells in the S‐phase and the response to the cytoreductive treatment was evident. Although a slightly higher percentage of major responses was found in euploid tumors, there is no evidence that flow‐cytometric DNA analysis can be helpful in the selection of patients for chemotherapy or chemoradiotherapy.© 1993 Wiley‐Liss, Inc.
Prediction of outcome in “Resectable” esophageal carcinoma
Authors: Sariego Joaquin , Mosher Steven , Byrd Michael , Matsumoto Teruo , Kerstein Morris 
Published: February 2007

AbstractA retrospective review was performed of 51 patients with esophageal carcinoma, deemed “resectable” by preoperative workup (e.g., CT scan, barium swallow), who presented to Hahnemann University Hospital between 1980 and 1991. This represented 21.8% of the total number of patients (234) with esophageal cancer who presented during that time period. At exploration, only 21 of the 51 patients (41%, or 9% overall) were truly resectable; 59% had more extensive disease than was appreciated preoperatively and that precluded resection for cure. Of the 21 patients resected for cure, 24% were alive at two years and only 5% were alive at 3 years. Neither age, gender, tumor type nor location in the esophagus significantly affected overall survival. Furthermore, none of these parameters, taken as independent variables, were able to predict true resectability at the time of operation. © 1993 Wiley‐Liss, Inc.We conclude that preoperative assessment of resectability, even in those patients who appear to be good candidates for cure, remains imprecise at best. Given an operative mortality rate of 6–8% (in most series) and an overall 3‐ to 5‐year survival rate of less than 10% (even in patients thought to have had curative resections), we reinforce the fact that meticulous patient selection and multimodality management strategies remain the keys to making any impact on this disease. © 1993 Wiley‐Liss, Inc.
Squamous cell carcinoma of the tongue: Experience with 86 consecutive cases
Authors: Reichard Kirk W. , Joseph Kimberly T. , Cohen Mimis , Greager John A. 
Published: February 2007

AbstractCharts from 86 patients treated for carcinoma of the tongue were reviewed to identify strategies that might improve patient outcome. Seventy‐one patients (83%) were black and 69 patients (80%) were male. Overall 2‐ and 5‐year survival rates were 20% and 12%, with stage‐specific 2‐year survivals of 71% (I and II, n = 7), 33% (III, n = 15), and 11% (IV, n = 64) (P < 0.01). Patients with well‐differentiated tumors (n = 27) had a higher 2‐year survival than that of the others (n = 53, 30% vs. 11%, P = 0.05). Six were unclassified. Twenty‐three (27%) patients underwent primary surgical resection and lymphadenectomy with or without adjuvant therapy. Two‐year overall and disease‐free survivals were 43% and 26%, respectively. Fifty (58%) patients received radiotherapy with or without chemotherapy, achieving 2‐year overall and disease‐free survivals of 12% and 6% (P< < 0.01). The remaining 13 patients received chemotherapy alone or no treatment and survived an average of 6 months. Distant metastasis were diagnosed in 14 patients (16%). Tongue carcinoma in this socioeconomic setting was characterized by late diagnosis and poor prognosis. Degree of tumor differentiation, disease stage, and treatment modality seemed to correlate with prognosis. Surgery, when possible, achieved superior results for disease control and survival. While cancer prevention efforts are critical, steps to identify high‐risk groups to implement early detection programs may help improve outcome for these patients. © 1993 Wiley‐Liss, Inc.
Inhibition of pulmonary tumor seeding by antiplatelet and fibrinolytic therapy in an animal experimental model
Authors: Brown Douglas C. , Purushotham Anand D. , George William D. 
Published: February 2007

AbstractFibrin and platelets contribute to the development of blood borne metastases by facilitating the arrest of tumor cell emboli in the microcirculation. We have previously demonstrated that the fibrinolytic agent strep‐tokinase inhibits pulmonary tumor cell seeding in an animal model. To determine whether this effect was potentiated by antiplatelet therapy, a further study was performed to assess the effect of streptokinase in combination with aspirin in a similar model. The results demonstrated that aspirin did not significantly enhance the antimetastatic effect of streptokinase (median: streptokinase = 60, streptokinase + aspirin = 60.5, P = 0.79, Mann Whitney). In a second series of experiments, the antimetastatic effect of streptokinase was compared with another fibrinolytic agent, human recombinant tissue plasminogen activator (rt‐PA). Fibrinolytic doses of streptokinase (30,000 units/kg) and rt‐PA (5 mg/kg) significantly reduced pulmonary tumor seeding when compared with controls (median: control = 48, streptokinase = 23, P<0.01, rt‐PA = 29, P < 0.001). There was no significant difference in pulmonary tumor seeding between the groups treated with streptokinase and rt‐PA (P = 0.56). The clinical implications of these findings are discussed. © Wiley‐Liss, Inc.
DNA ploidy, proliferative activity, and concanavalin A reactivity in breast cancer
Authors: Paydas Semra , Sarpel Suleyman , Gilman‐Sachs Alice , Tuncer Ilhan , Pehlivan Sacide , Tunali Nurdan , Zorludemir Suzan , Burgut Refik , Kucuk Omer 
Published: February 2007

AbstractParaffin‐embedded primary tumor specimens from 48 patients with breast cancer were examined for DNA ploidy, S‐phase fraction (SPF), and concanavalin A (Con A) reactivity. The results were correlated with clinicopathological prognostic factors, including patients' age and menopausal status, stage of disease, nuclear grade, and size of the primary tumor. There were no associations among ploidy, SPF, Con A reactivity, and menopausal status, stage of disease, or size of the primary tumor. However, among patients who were 50 years or older, 81 % had diploid tumors and 73% had good reactivity (3+ or better staining score) with Con A. In contrast, among patients who were younger than 50 years, 45% had diploid tumors (P < 0.05) and 21% had good Con A reactivity (P < 0.05). Seven of 19 (37%) poorly differentiated tumors and 7 of 9 (78%) moderately differentiated tumors had good reactivity with Con A (P < 0.05). Reactivity of tumor cells with Con A in primary breast cancer tissues deserves further evaluation as a potential biomarker of prognosis. © 1994 Wiley‐Liss, Inc.
The synergistic antitumor effect of recombinant interleukin‐1 and low‐dose of cyclophosphamide in tumor‐bearing mice
Authors: Harada Takehisa , Kan Norimichi , Ichinose You , Moriguchi Yoshio , Li Li , Sugie Tomoharu , Okino Takashi , Imamura Masayuki 
Published: February 2007

AbstractIntraperitoneal (i. p.) treatment of MOPC104E ascitic tumor‐bearing BALB/c mice with interleukin‐1 (IL‐1) followed by a low dose of cyclophosphamide (CPA) resulted in synergistic prolongation of their survival time. This antitumor effect was abolished when administration of CPA preceded that of IL‐1. The combined i. p. therapy also eradicated subcutaneous (s. c.) tumors, indicating a systemically operating antitumor mechanism. In Winn assay, splenocytes from MOPC104E‐bearing mice treated with the combined therapy completely suppressed the growth of MOPC104E cells, but not that of another syngeneic tumor cell line, RL ♀ ‐8 cells. This tumor‐neutralizing activity was completely abrogated by treatment with anti‐asialo‐GM1 or anti‐Thy 1.2 and complement, and reduced by treatment with anti‐Lyt2.2 and complement. Treatment of splenocytes with 1‐leucine methyl ester (LeuOMe), which depletes natural killer (NK) cells and macrophages in vitro, did not affect the neutralizing activity. © 1994 Wiley‐Liss, Inc.
Plasma D‐dimer and peritoneal CA‐125 levels as predictors of disease status in ovarian carcinoma
Authors: Rose Peter G. , Terrien Jill M. , Baker Stephen 
Published: February 2007

AbstractAlthough serum CA‐125 has improved our ability to monitor tumor response in ovarian carcinoma, ∼50% of patients with normalization of CA‐125 have persistent disease at second look laparotomy. Peritoneal CA‐125 and plasma D‐Dimer levels were studied to determine if their use could increase the sensitivity for persistent ovarian carcinoma in a population of patients with normal physical examinations, radiologic studies, and serum CA‐125 values. Plasma D‐Dimer levels were obtained prior to second look laparotomy. The results of peritoneal CA‐125 and plasma D‐Dimer studies were compared to second look laparotomy results. Differences were evaluated with a one‐way analysis of variance. Twenty‐seven patients were studied. Peritoneal CA‐125 was evaluated in 23 patients and ranged from <6.3–223 U/ml. There was no statistical difference in peritoneal CA‐125 levels between patients whose second look laparotomies were negative, or microscopically or macroscopically positive. D‐Dimer was elevated in three patients, all of whom had macroscopically positive second look findings. The sensitivity for positive second look findings was only 27%. Minimally elevated plasma D‐Dimer levels were specific but not sensitive for persistent disease and peritoneal CA‐125 was not predictive of disease status. © 1994 Wiley‐Liss, Inc.
Unilateral pulmonary artery occlusion inhibits growth of metastatic sarcoma in the rat lung
Authors: Wang Hong‐Yue , Ng Bruce , Ahrens Charles , Burt Michael 
Published: February 2007

AbstractTumors depend on their blood supply for growth. The blood supply to metastatic neoplasia of lung is usually from the pulmonary circulation or both the pulmonary and systemic circulation. The antineoplastic effect of pulmonary artery occlusion was investigated in a rat model of methylcholanthrene‐induced metastatic pulmonary sarcoma. Left pulmonary artery ligation was performed on day 7 after tumor inoculation, and animals were sacrificed on day 14. The tumor burden of the left lung decreased 44% when compared with the control group. The survival of non‐tumor‐bearing rats undergoing left pulmonary artery ligation for 24 hours followed by right pneumonectomy after 2 weeks was also studied. No significant lung damage after a period of left pulmonary artery ligation was seen, as evidenced by both survival after contralateral right pneumonectomy and histology. Balloon occlusion of pulmonary artery, together with regional chemotherapy for patients with lung metastases, may warrant investigation. © 1994 Wiley‐Liss, Inc.
Rapid and accurate method for delineating cancer lesions in laparoscopic colectomy using activated carbon injection
Authors: Kitamura Kazuya , Yamane Tetsuro , Oyama Takayuki , Shimotsuma Masataka , Hagiwara Akeo , Yamaguchi Toshiharu , Sawai Kiyoshi , Takahashi Toshio 
Published: February 2007

AbstractThe aim of our study was to evaluate the clinical efficacy of preoperative injection of activated carbon in delineation of cancer location in laparoscopic colectomy. Activated carbon particles were injected during endoscopy into the normal colonic wall surrounding cancer lesions in five cases of early colon cancer, prior to laparoscopic surgery. The carbon‐stained area was clearly recognizable as a blackened patch on the serosal surface of the colon. Using the carbon‐stained area as a reference point, partial colectomies were successfully performed on all five patients. The preoperative injection of activated carbon assisted in the intraoperative delineation of early colonic cancer lesions. This method is recommended for the rapid and accurate delineation of early colonic cancers in laparoscopic surgery. © 1995 Wiley‐Liss, Inc.
Malignant melanoma of the anorectal region
Authors: Konstadoulakis Manoussos M. , Ricaniadis Nicolaos , Karakousis Constantine P. , Walsh Debra 
Published: February 2007

AbstractThe charts of 15 patients with malignant melanoma of the anorectal region treated at Roswell Park Cancer Institute in the period 1975–1991 were reviewed. All the lesions except one developed at the pectinate line, in the area of transitional mucosa.Two of the patients at the time of initial presentation had distant metastases. Of the remaining 13, 8 were treated with abdominoperineal resection (APR) and 5 with local excision (LE). The incidence of local recurrence was 50% in the LE group and 22% in the APR group. Patients treated with APR had a 25%, 5‐year survival rate compared with 0% for those treated with LE, although one of the latter group died 55 months following LE due to unrelated causes without recurrence. The median survival of those with LE was 15.7 months and of those with APR 13.7 months. © 1995 Wiley‐Liss, Inc.
Diagnosis and treatment of metachronous cancers in the esophagus and the head and neck region
Authors: Yoshino Kunihide , Endo Mitsuo , Ishikawa Norihiko , Takahashi Yuzo 
Published: February 2007

AbstractThe esophagus and the head and neck region, both having the squamous epithelium, are thought to be subject to the same carcinogenic factors. This report discusses the diagnosis and treatment of secondary cancer detected following the treatment of primary cancer in 21 patients who had metachronous cancer comprising esophageal cancer and head and neck cancer. The secondary cancer was already advanced when detected despite the fact that almost all patients were followed up regularly at the outpatient clinic of the facility where the primary cancer was treated. Although surgical treatment of the secondary cancer was similar to that of the usual primary cancer, the prognosis for the former was poor, indicating that the prognosis tends to be determined by the disease stage of the secondary cancer. Early detection of the secondary cancer requires esophagoscopy using the iodine dye method or close examination of the head and neck region at an otolaryngologic outpatient clinic at the time of treatment of the primary cancer and thereafter at 6‐ to 12‐month intervals. © 1995 Wiley‐Liss, Inc.
Von recklinghausen's disease associated with duodenal somatostatinoma: Contrast of duodenal versus pancreatic somatostatinomas
Authors: Mao Chuanyan , Shah Ajay , Hanson Daniel J. , Howard John M. 
Published: February 2007

AbstractA case of Von Recklinghausen's disease with duodenal somatostatinoma is reported. A search of the world's literature revealed 27 patients with Von Recklinghausen's disease associated with an immunohistologically proved duodenal somatostatinoma. Twenty‐nine cases of duodenal somatostatinoma not associated with Von Recklinghausen's disease and 32 cases of pancreatic somatostatinomas have been identified for comparison. While their histology may be similar in many respects, the duodenal and pancreatic somatostatinomas show significant differences, especially in hormonal and growth behaviors.In contrast to its pancreatic counterpart, the duodenal somatostatinoma is frequently associated with Von Recklinghausen's disease, is seldom associated with a recognizable “somatostatin syndrome,” often contains psammoma bodies, and is less frequently associated with demonstrable metastases at the time of operation.
Prognostic value of p53 protein in esophageal adenocarcinoma
Authors: Casson Alan G. , Kerkvliet Nancy , O'Malley Frances 
Published: February 2007

AbstractThe p53 tumor suppressor gene has recently been implicated in the pathogenesis of human esophageal cancer. To assess potential clinical applications for this molecular marker, 52 patients with primary esophageal adenocarcinoma were studied prospectively. p53 protein accumulation was evaluated immunohistochemically in surgically resected esophageal tissues, and correlated with clinicopathologic findings and survival. All patients underwent total esophagectomy with reconstruction, completely resecting all gross disease. Immunopositivity was seen in 28 of 52 (54%) primary adenocarcinomas, and was associated with a trend towards reduced postoperative survival (P = 0.06; log‐rank). Regional lymph node metastases were found in 30 (58%) patients. Thirteen of 30 (43%) regional lymph node metastases were immunopositive, which was the most significant predictor of overall survival by univariate (P = 0.02; log‐rank) and multivariate analysis (P = 0.05; Cox regression). This study further implicates p53 in esophageal tumor development and progression. The immu‐nohistochemical finding of p53 protein in primary esophageal adenocarcinomas and regional lymph node metastases appears to be associated with reduced overall survival for this disease. If these preliminary observations are confirmed in larger prospective studies, p53 may prove to be a clinically useful molecular marker in future clinical trials of esophageal cancer. © 1995 Wiley‐Liss, Inc.