bluuebunny/crossref_metadata_2025_split huggingface dataset:
Studies on the effects of adenosine upon tumor growth in mice
Authors: Strong Leonell C. , Ishmael Debra 
Published: February 2007

AbstractGrowth rates of spontaneous tumors of C3H and C3HB inbred mice were averaged together. Four series of tests using adenoisine as an inhibitor of tumor growth were used in a 0.05 molar concentration. The four series used were, (a) adenosine I, (b) adenosine II both for intraperitoneal injections, used singly and then combined for comparative analysis, (c) adenosine III, and (d) adenosine IV, both used for subcutaneous injections, of which series III was used in distilled water and series IV in physiological salt solution. Observations on tumor size were plotted at five time‐period intervals in order to determine growth rates. It was found that adenosine IV, in physiological salt solution, gave the greatest deviation from from the controls both in inhibiting tumor growth and also in stimulating tumor growth in mice of the different age and generation classes as determined in a lineal descent from a mouse which had received a liver‐emulsion injection. The subcutaneous injections of adenosine III gave only an early inhibition of tumors whereas the intraperitoneal injections of adenosine I and II brought about a constant inhibition of tumor growth during the life span of tumor‐bearing mice. Variations in the effect of adenosine upon tumor growth were found to be dependent upon 1. the age of the mouse and 2. the generation of descent removed from the original liver treatment (Strong, 1969a). These tests for tumor growth, therefore, provided a close examination of some of the variables involved in the use of adenosine as an inhibitor and as a stimulator of spontaneous tumor growth rates in mice.
Trial of radiolabeled antibody localization in metastases of a patient with a tumor containing carcinoembryonic antigen (CEA)
Authors: Reif A. E. , Curtis L. E. , Duffield R. , Shauffer I. A. 
Published: February 2007

AbstractAn attempt to detect metastatic cancer by the specific localization of radiolabeled antibody is reported. The patient had far advanced carcinoma of the colon and a high level of carcinoembryonic antigen (CEA) in serum. She was given whole unabsorbed rabbit antiserum to CEA intravenously, to determine whether CEA can be removed from the circulation. A transient partial depression of the CEA level in serum was obtained, followed by a rebound. Absorbed and purified antibody radiolabeled with 131 I was injected intravenously 19 days later. Total body scans showed no evidence of the localization of the radiolabel in cancer tissue. After another 5 days, injection of the same radiolabeled antibody solution directly into the hepatic artery was attempted. Again, no evidence of localization in liver metastases was obtained. All three infusions of antibody to CEA caused reactions that were ameliorated by Benadryl. Future trials may have better Success if monospecific anti‐CEA is used and patients are chosen who have CEA‐producing tumors, but whose serum CEA levels are low or negative.
Speech and vocational rehabilitation of the laryngectomized patient
Authors: Sako Kumao , Cardinale Salvatore , Marchetta Frank C. , Shedd Donald P. 
Published: February 2007

AbstractEighty‐five patients underwent total laryngectomy or total laryngectomy in continuity with a radical neck dissection during the five year period 1964 through 1968. Forty‐eight patients (56.4%) were able to learn esophageal speech; six were rated as excellent, 25 as good, eight as fair, and nine as poor. Nineteen patients (22.4%) who either could not learn esophageal speech or had no desire to learn were able to communicate with the aid of an electronic speaking device.Of the 53 patients gainfully employed outside the home prior to surgery, only 22 were able to return to work. Forty of the 48 patients who learned esophageal speech were gainfully employed outside the home before surgery, but only 19 (47%) were able to return to work.
Spontaneous renal subcapsular hematoma renal angiography as a diagnostic aid
Authors: Choi S. , Jennings E. 
Published: February 2007

AbstractPrior to the development of angiography, a definite diagnosis of spontaneous subcapsular renal hematoma was not often made preoperatively. The classic triad of blood loss, pain, and mass on the affected side is seldom presented by the patient. The one constant finding on scout film is an enlarged renal shadow, presenting a problem in differential diagnosis.Chief among cause of subcapsular renal hemorrhage are trauma, tumor, infarct, arteritis, and bleeding diathises.Selective renal arteriography gives specific information about the renal vascular supply and the state of the renal parenchyma not available by other means. Diagnosis of subcapsular renal hematom is facilitated by this modality. A correct diagnosis of subcapsukr renal hematoma may well spare an otherwise innocent kidney.A review of current literature was undertaken, and three documented cases of spontaneous subcapsular hematoma diagnosed prior to surgery and confirmed at surgery are presented.
Squamous cell carcinoma of the oral cavity — chronic oral ulcerative disease as a possible etiologic factor
Authors: Faraci Robert P. , Schour Lionel , Graykowski Edward A. 
Published: February 2007

AbstractThis report documents the association of carcinoma of the oral cavity with chronic oral ulcerative disease in two patients. This association has not previously been documented in the surgical literature. Both patients in this report had chronic oral ulcerative disease preceding their cancers; however, the common etiologic factors for oral cancer were not detected in either case. Oral lichen planus and pemphigus vulgaris should be considered as potentially premalipant tenons and should be treated accordingly.
Duodenoscopy and endoscopic retrograde choledochopancreatography: Present position in relation to periampullary and pancreatic cancer
Authors: Blumgart L. H. 
Published: February 2007

AbstractDuodenoscopy and endoscopic retrograde Choledochopancreatography represent a major advance in the diagnosis of periampullary and pancreatic lesions. Instruments, techniques and complications are reviewed. A combination of endoscopy and ERCP will yield diagnosis in a high proportion of patients suspected of pancreatic or ampullary carcinomata. Information is obtained which is not only of diagnostic value but is important in the surgical treatment of such patients.
Considerations appropriate to a clinical trial of definitive radiation therapy in adenocarcinoma of the pancreas
Authors: Cavanaugh Patrick J. 
Published: February 2007

AbstractThe Author describes criteria for selection of patients who might be eligible for entry into a clinical trial of definitive Radiation Therapy for adenocarcinoma of the pancreas. Most emphasis is placed on careful surgical staging, target volume and location, and the use of bypass procedures when appropriate.
Prospectives for cell and organ culture systems in the study of pancreatic carcinoma
Authors: Jamieson J. D. 
Published: February 2007

AbstractAdenocarcinoma of the pancreas is presumed to arise from ductal cell precursors. This brief article questions the definitions on which this assumption is based and suggests possible ways to answer the question since for future studies on the etiology of this cancer it is imperative to study the appropriate cell of origin. Possible approaches for future work on pancreatic carcinogenesis utilizing cell and organ culture systems are discussed.
Soft tissue sarcomas of the extremities: Their natural history, treatment, and radiation sensitivity
Authors: Gilbert Harvey A. , Kagan A. Robert , Winkley John 
Published: February 2007

AbstractThe authors have attempted to explore the factors that influence the clinical course of a patient with a soft tissue tumor of the extremity (local recurrence, distant metastasis, and survival) by reviewing the literature as well as the cases at their institution. Do histology, site (proximal extremity versus distal extremity), age, or treatment significantly influence the natural history of the disease?As regards to treatment, the following questions must be answered. (1) Should the affected extremity be preserved? (2) Does the extent of local treatment really effect the likelihood of these tumors to disseminate? (3) Should ancillary local treatment such as radiation therapy be used and in what fashion? (4) If extremity‐saving techniques were found to be of equal value to amputation, what is the quality of survival in a patient with a compromised extremity (wide excision and irradiation), and would amputation with rehabilitation provide equal or better survival quality?
Rehabilitation problems of head and neck cancer patients
Authors: Shedd Donald P. 
Published: February 2007

AbstractHead and neck cancer and its treatment result in varying degrees of disability affecting various organ systems. Ideal treatment of such patients requires a unit capable of managing problems in the areas of:

Reconstructive surgery
Maxillofacial prosthodontia
Dentistry
Deglutition disorders
Psychological, social, and vocational rehabilitation
Provision of such facilities in an integrated manner will give the patient the optimal chance for rehabilitation from the complex disabilities occurring in head and neck cancer.
Insulin metabolism in depancreatized dogs during hemorrhagic shock
Authors: Lau Tak S. , McMillan Neville , Cherrington Alan , Lo Siu , Drucker William R. , Koven Irving H. 
Published: February 2007

AbstractThis study was done to determine why the plasma insulin remained elevated during shock. Mongrel female dogs (12‐15 kg) were depancreatized and maintained on a constant intraportal infusion of porcine insulin while they were bled to reduce and maintain the mean arterial blood pressure at 50 mm Hg for 165 min. Blood samples were taken for glucose and plasma insulin at 15 min intervals. The data show that there was a progressive rise of plasma insulin during the course of hemorrhagic shock. This occurred despite a constant infusion of insulin, the sole source of insulin available to these depancreatized dogs. Since removal of plasma insulin is largely due to insulin utilization, our findings imply that the rise of plasma insulin in hemorrhagic shock is caused by decreased utilization.
Adoptive transfer of tumor immunity between twins by in vitro immunized nodal macrophages and lymphocytes: Reversal of serum enhancement
Authors: Hickok David F. , Miller Lynda 
Published: February 2007

AbstractThe lymphocytes and serum of a nonidentical twin male with advanced colon cancer were evaluated in vitro for their ability to inhibit the growth of autologous tumor cells. The patient's serum enhanced autologous tumor cell growth. Three siblings including an HL‐A matched grade A female twin underwent similar studies. Benign lymph nodes of the twins and one sibling were evaluated for the ability of nodal macrophages to be sensitized to the patient's tumor antigen. The male twin patient received in‐tralymphatically in vitro sensitized nodal macrophages and lymphocytes from the female twin donor. Thirty days after treatment the patient's lymphocytes and serum inhibited the growth of autologous tumor cells.
Studies of receptors on normal and malignant tissue from man
Authors: Humphrey Loren J. 
Published: February 2007

AbstractReceptor studies on normal and malignant human tissues were carried out. Erythrocyte receptor studies failed to show differences between malignant and normal tissues; both apparently have a receptor for rat erythrocytes, a hemolysin for monkey erythrocytes, and an agglutinin for rabbit erythrocytes.Fc receptors were found in several malignant tissues and only an occasional normal tissue, except for a patient who died of sepsis.
The influence of pineal ablation and administration of melatonin on growth and spread of hamster melanoma
Authors: El‐Domeiri Ali A. , Gupta Tapas K. Das 
Published: February 2007

AbstractRemoval of the pineal organ resulted in increase in the growth of transplanted melanoma in hamsters. Administration of melatonin, which is the principle indole found in pineal tissue, to pinealectomized animals abolished this effect. Therefore it was concluded that the effect of pinealectomy on tumor growth is due to a lack of endogenous melatonin. Administration of large doses of melatonin (4 mg/ day) to intact animals, however, did not influence the rate of tumor growth, indicating that the drug has no direct effect on tumor growth and that the changes produced by melatonin deficiency is perhaps due to a complex reaction involving centers in the hypothalamus and brain stem.Certain morphologic changes were noted in the pineal organs of animals treated with exogenous melatonin. Although the biologic significance of these changes is not clear, study of the electron micrographs indicates that the pinealocytes of the melatonin‐treated animals are in a state of increased activity.
Differences in potentiation of melanoma growth by absorbable and nonabsorbable suture
Authors: Pendergrast W. J. , Futrell J. W. , Mardiney M. R. 
Published: February 2007

AbstractThis study demonstrates that various suture materials have different influences on tumor take and growth. When used in an area containing 105 or greater tumor cells, all suture types studied potentiated tumor growth. At subclinical tumor cell doses ‐ that is, 1,000 or fewer cells that do not normally grow to a clinically detectable tumor ‐‐‐ silk and steel increased tumor occurrence. In comparison, monofilament nylon, polyglycolic acid, and chromic suture did not potentiate tumor growth. This phenomenon of increased tumor growth associated with certain suture types appears to be related to the physical characteristics of the suture involved, although the interaction of the chemical breakdown products of the suture material with the local tumor cells is under investigation. The type of suture material used may play a significant role in the subsequent development of local recurrence of cancer.
Mesenchymoma: A review of literature and report of two cases
Authors: Januska James , Leban Stanley G. , Mashberg Arthur 
Published: February 2007

AbstractBoth benign and malignant varieties of the mesenchymoma have been described.Previously reported cases of mesenchymoma in the head and neck are rare. Two cases of mesenchymoma occurring intraorally are reported here. In each case local excision has effected apparent cure, for periods of 12 yr and 8 mo, respectively. Local excision is advocated as the primary treatment for such lesions occurring in the oral cavity. Although recurrences in areas other than the oral cavity tend to undergo malignant changes, this phenomenon has not been demonstrated in lesions occurring in oral tissues.
The tricho system: Hypertrichosis, radiation, and cancer
Authors: Lapidus Steven M. 
Published: February 2007

AbstractFive women in their 6th to 8th decades were treated for facial hypertrichosis in Erie, Pennsylvania, 30 to 40 years ago. The epilations were performed with an X‐ray device called “Tricho System,” which was manufactured, sold, and proclaimed safe by its physician‐inventor. The beauty shop operator who administered these treatments may or may not have received “instruction” by the company in the operation of the equipment.At varying intervals, each of the 5 women developed radiodermatitis and basal cell and/or squamous cell carcinoma at the sites of epilation. All presented to the plastic surgical service at the Hamot Medical Center in Erie, Pennsylvania. Two underwent massive radical resective surgery, 2 required extensive excision and resurfacing, and 1 refused resective surgery although she had had a previous surgical attempt 17 years earlier. Case histories are presented in detail. This series is representative of the epidemic nature of Tricho‐System‐induced disease.
The metastatic potential of metastases: A case report
Authors: Thomas James H. , Panoussopoulos Dimitrios , Jewell William R. 
Published: February 2007

AbstractConfirmation of the potential for metastases to metastasize in humans, especially those patients with a well controlled primary, should alter present approaches to patients with malignant disease and isolated recurrences. Reported herein is a case clearly demonstrating the metastatic potential of metastases.
Technical aspects of reed fistula speech rehabilitation following pharyngolaryngectomy
Authors: Shedd D. , Schaaf N. , Weinberg B. 
Published: February 2007

AbstractThe reed fistula method is under development as a method of voice restoration in patients who have undergone laryngopharyngectomy. Introducing extrinsic sound into the pharynx involves a series of biomedical engineering problems. The approaches to solution of these problems are covered in the present article.
Multiple colorectal carcinoma and barium enema perforation
Authors: Krausz M. , Gordon R. L. 
Published: February 2007

AbstractA patient with simultaneous metachronous carcinoma and polyps of the large bowel is presented. The importance of carcinoma as a predisposing cause to perforation during barium enema is stressed. In view of the considerable incidence of recurrent large bowel tumors, careful routine follow‐up studies should be undertaken and extreme caution exercised during the barium enema.
Hemodialysis in patients with carcinoma
Authors: Baumgartner George , Major Alice , Merrin Claude E. 
Published: February 2007

AbstractAll patients who underwent hemodialysis as part of their treatment for cancer at Roswell Park Memorial Institute from 1965 to 1974 were retrospectively studied to determine the value of hemodialysis in cancer patients. Approximately 25% (8 cases) lived 5 weeks or longer in spite of advanced renal failure and carcinoma with no severe complications. The longest survivor is still alive after ten years.
Relationship of causative factors in spontaneous regression of cancer to immunologic factors possibly effective in cancer
Authors: Cole Warren H. 
Published: February 2007

AbstractIn a book written by Everson and Cole (1966) on spontaneous regression 176 examples of the phenomenon were encountered in the medical literature from 1900 to 1964, supplemented by cases referred by friends. No common denominator of explanations were found. Various types of trauma (e.g., biopsy, incomplete excision), transfusions, infection, hormone changes, drugs, etc were encountered as possible causative factors. Most significant of all factors was encountered in the 13 examples of spontaneous regression of the bladder; in this series regression of the tumor occurred in 10 after transplantation of the ureters out of the bladder.A consideration and discussion of various reactions in human beings associated with therapeutic regressions have been reviewed hoping to develop a correlation between the two types of regression. At the time of publication of our monograph 9 years ago we were unable to suggest any mechanisms which might explain the regressions. However, since that time so many advances have been made in immunology that it appears now that a stimulation of the immune process might explain most of the regressions. We are just beginning to learn a few methods of stimulating the immune process. Use of BOG is one of the best examples of this stimulating process; other bacterial agents, or fractions, are known to have this action. No doubt there are innumerable others unknown, some of which might explain spontaneous regressions. It would appear that hormonal changes might be responsible for many of the regressions but this author doubts it explains many. More is known at the present time about cellular immunity than humoral immunity, but greater possibilities surely lie in humoral immunity. The blocking and unblocking activities developed by the Hellströms and associates are no doubt important. Immunoglobulins exert a very important role in the immune process; antibodies may consist of immunoglobulins but much more needs to be known before this relationship can be understood.The recent report (Amery, 1975) that levamisole (given at the time of resection of the lung for carcinoma) improves patient survival is exciting. Amery believes the drug may prevent the hematogenous spread of the tumor during surgery and/or may decrease the immunosuppression caused by a major operation.
Combination chemotherapy in the treatment of advanced breast cancer
Authors: Rosner Dutzu , Nemoto Takuma , Dao Thomas L. 
Published: February 2007

AbstractSeventy‐two women with metastatic breast cancer were treated with multiple‐agent chemotherapy. Fifty women were treated with 5 drugs in combination: 5‐FU, methotrexate, vincristine, cytoxan, and prednisone; 22 were treated with the combination of 3 drugs: 5‐FU, cytoxan, and prednisone. In 14 patients receiving 5 drugs and in 22 receiving 3 drugs, the multiple chemotherapy was the primary palliative treatment of extensive visceral metastases unsuitable for adrenalectomy. Results were similar with 6 responders in 14 (0.43) receiving 5 drugs, and 10 responders in 22 (0.45) receiving 3 drugs. The remaining 36 patients who were given 5‐drug therapy all had previous adrenalectomy, and there were 16 responders (0.44).Toxicities from 3‐drug treatment were substantially less severe than those from the 5‐drug combination therapy. Whereas treatment‐related death occurred in 6 of 50 patients receiving the 5‐drug combination, no such incidence occurred in those receiving 3‐drug combination therapy.
Kidney total fatty acids in renal cell carcinoma and infection
Authors: Gershbein Leon L. , Baburao K. , Costich Kenneth J. , Pedroso Aldo F. 
Published: February 2007

AbstractLipids extracted from the kidneys of adults with renal cell carcinoma or infection after careful dissection of lesions and from organs showing minimal alterations were saponified and the fatty acids converted to the methyl esters. Gas chromatographic criteria were applied to the esters as such and to hydrogenated aliquots, and the relative percentages of the component acids were ascertained. The various lipid classes were well represented in the total fatty acid mixtures. The unsaturated acids ranged higher than the saturated homologs. Comparisons of the fatty acids were carried out on the basis of age, sex, kidney position, mode of acquisition (surgery and autopsy), and pathology. Several small but statistically significant differences were discerned according to the categories but with few exceptions, these involved acids occurring at low levels and with wide variance.
Hemangiosarcoma of the spleen: Report of a case and review of previously reported cases
Authors: Aranha Gerard V. , Gold J. , Grage Theodor B. 
Published: February 2007

AbstractSplenic hamangiosarcomas are rare tumors, usually discovered at autopsy. In a few instances the diagnosis was made premortem, at the time of splenectomy for spontaneous rupture. The tumors usually present with abdominal pain, left upper quadrant mass and tenderness, and occasionally with a microangiopathic type of anemia. The histogenesis of the tumor is in dispute. Some authors feel that they are degenerations of hemangiomas. Others feel that they arise de novo in the spleen. There is no proven association of thorotrast administration or vinyl chloride exposure to the development of hemangiosarcomas in the spleen. The prognosis of the tumor is uniformly poor and most of the patients surviving laparotomy have followed a uniformly fatal clinical course. In a few cases treated with chemotherapy there has been no evidence of clinical benefit. The case report in this article presented with essentially all the features enumerated above.