bluuebunny/crossref_metadata_2025_split huggingface dataset:
A protocol for harvesting biodiversity data from Facebook
Authors: Chowdhury Shawan , Ahmed Sultan , Alam Shofiul , Callaghan Corey T. , Das Priyanka , Di Marco Moreno , Di Minin Enrico , Jarić Ivan , Labi Mahzabin Muzahid , Rokonuzzaman Md. , Roll Uri , Sbragaglia Valerio , Siddika Asma , Bonn Aletta 
Published: March 2024

AbstractThe expanding use of community science platforms has led to an exponential increase in biodiversity data in global repositories. Yet, understanding of species distributions remains patchy. Biodiversity data from social media can potentially reduce the global biodiversity knowledge gap. However, practical guidelines and standardized methods for harvesting such data are nonexistent. Following data privacy and protection safeguards, we devised a standardized method for extracting species distribution records from Facebook groups that allow access to their data. It involves 3 steps: group selection, data extraction, and georeferencing the record location. We present how to structure keywords, search for species photographs, and georeference localities for such records. We further highlight some challenges users might face when extracting species distribution data from Facebook and suggest solutions. Following our proposed framework, we present a case study on Bangladesh's biodiversity—a tropical megadiverse South Asian country. We scraped nearly 45,000 unique georeferenced records across 967 species and found a median of 27 records per species. About 12% of the distribution data were for threatened species, representing 27% of all species. We also obtained data for 56 DataDeficient species for Bangladesh. If carefully harvested, social media data can significantly reduce global biodiversity knowledge gaps. Consequently, developing an automated tool to extract and interpret social media biodiversity data is a research priority.
Destructive fishing: An expert‐driven definition and exploration of this quasi‐concept
Authors: McCarthy Arlie Hannah , Steadman Daniel , Richardson Hannah , Murphy Jack , Benbow Sophie , Brian Joshua I. , Brooks Holly , Costa‐Domingo Giulia , Hazin Carolina , McOwen Chris , Walker Jessica , Willer David F. , Abdi Mohamad , Auster Peter J. , Bealey Roy , Bensted‐Smith Robert , Broadburn Kathryn , Carvalho Gonçalo , Collinson Tom , Erinosho Bolanle , Fabinyi Michael , Febrica Senia , Forbi Wilson Ngwa , Garcia Serge M , Goad David , Goldsworthy Lynda , Govan Hugh , Heaphy Charles , Hiddink Jan Geert , Hosch Gilles , Kachelriess Daniel , Kinch Jeff , Lancaster Alana Malinde S. N. , Le Manach Frédéric , Matthews Thomas , Ortiz Alfonso Medellín , Morgan Alexia , Motta Helena , Murua Hilario , Namboothri Naveen , Ndiritu Evelyne , Passfield Kelvin , Pilcher Nicolas J. , Portus James O. , Rguez‐Baron Juan M. , Robertson Morven , Sharma Abhilasha , Suazo Cristián G. , Tamini Leandro Luis , Vilata‐Simón Juan , Mukherjee Nibedita 
Published: March 2024

AbstractNumerous policy and international frameworks consider that “destructive fishing” hampers efforts to reach sustainability goals. Though ubiquitous, “destructive fishing” is undefined and therefore currently immeasurable. Here we propose a definition developed through expert consultation: “Destructive fishing is any fishing practice that causes irrecoverable habitat degradation, or which causes significant adverse environmental impacts, results in long‐term declines in target or nontarget species beyond biologically safe limits and has negative livelihood impacts.” We show strong stakeholder support for a definition, consensus on many biological and ecological dimensions, and no clustering of respondents from different sectors. Our consensus definition is a significant step toward defining sustainable fisheries goals and will help interpret and implement global political commitments which utilize the term “destructive fishing.” Our definition and results will help reinforce the Food and Agricultural Organization's Code of Conduct and meaningfully support member countries to prohibit destructive fishing practices.
Enzymatic coloration of polyamide fabrics and its comparison with conventional dyeing
Authors: Atav Rıza , Karagören Ece , Soysal Selma , Yakin İsmail 
Published: March 2024

AbstractAmong the textile wet processes, the colouring process is the process step that causes the most environmental pollution. New approaches that support sustainable production instead of environmentally harmful processes are extensively researched in the literature. When considering substitution of chemical processes with environmentally friendly methods, one of the issues that comes to mind is enzymatic processes. It is noteworthy that in recent years, interesting and promising studies on the use of laccase enzymes in textile dyeing have been published in the literature. However, studies on enzymatic colouring are still very limited and sufficient success has not been achieved especially on polyamide. The aim of this study is to develop an environmentally friendly enzymatic dyeing method, which can be an alternative to dyeing polyamide knitted fabrics with 1:2 metal complex dyes according to the exhaustion method. For this purpose, various phenol and amine compounds, and their mixtures were used as precursor, and the colours that can be obtained by enzymatic colouring have been determined. In addition, optimisation of enzymatic colouring conditions (enzyme concentration, temperature and time) was carried out for the precursors that gave the best results in terms of colour and fastness. Furthermore, enzymatic dyeing was compared with conventional 1:2 metal complex dyeing in terms of technical and economic aspects. The reaction pathways in enzymatic coloration with laccase enzyme by using various precursors were also explained by Fourier‐transform infrared (FTIR) analysis.
Long‐term outcomes for pediatric heart transplant recipients transitioning to adult care teams
Authors: Donald Elena M. , Oren Daniel , DeFilippis Ersilia M. , Rubinstein Gal , Moeller Catherine M. , Lee Hannah Y. , Maldonado Alejandro , Portera Mary Virginia , Fuselier Byron , Jackson Ruslana , Clerkin Kevin. J. , Fried Justin. A. , Raikhelkar Jayant , Lee Sun Hi , Latif Farhana , Lytrivi Irene D. , Zuckerman Warren A. , Richmond Marc E. , Sayer Gabriel , Uriel Nir 
Published: March 2024

AbstractBackgroundThere are limited data evaluating the success of a structured transition plan specifically for pediatric heart transplant (HT) recipients following their transfer of care to an adult specialist. We sought to identify risk factors for poor adherence, graft failure, and mortality following the transfer of care to adult HT care teams.MethodsWe retrospectively reviewed all patients who underwent transition from the pediatric to adult HT program at our center between January 2011 and June 2021. Demographic characteristics, comorbid conditions, and psychosocial history were collected at the time of HT, the time of transition, and the most recent follow‐up. Adverse events including mortality, graft rejection, infection, and renal function were also captured before and after the transition.ResultsSeventy‐two patients were identified (54.1% male, 54.2% Caucasian). Mean age at the time of transition was 23 years after a median of 11.6 years in the pediatric program. The use of calcineurin inhibitors was associated with reduced mortality (HR .04, 95% CI .0–.6, p = .015), while prior psychiatric hospitalization (HR 45.3, 95% CI, 6.144–333.9, p = .0001) was associated with increased mortality following transition. Medication nonadherence and young age at the time of transition were markers for high‐risk individuals prior to the transition of care.ConclusionsTransition of HT recipients from a pediatric program to an adult program occurs during a vulnerable time of emerging adulthood, and we have identified risk factors for mortality following transition. Development of a formalized transition plan with a large multidisciplinary team with focused attention on high‐risk patients, including those with psychiatric comorbidities, may favorably influence outcomes.
A semantic guide‐based embedding method for knowledge graph completion
Authors: Zhang Jinglin , Shen Bo , Wang Tao , Zhong Yu 
Published: March 2024

AbstractKnowledge graph embedding aims to map entities and relations into a low‐dimensional vector space for easy manipulation. However, frequent entities are updated more often than infrequent ones during training, leading to inadequate representation of the latter's embeddings, which, in turn, affects the model's overall performance in downstream tasks. To address this issue, we propose a semantic information guide and enhance (SGE) method. The SGE tackles the heterogeneity in the frequency of entities through semantic reconstruction and a guidance network. The semantic reconstruction strengthens the semantic relevance among all entities and connects entities with different frequencies in semantic space. The guidance network extends these connections to knowledge space, enhancing the expression abilities of infrequent entities’ embeddings without compromising the embeddings of frequent entities. Experiments with four commonly used benchmark datasets show that the SGE method improves the performance of baseline models in most cases and that the method is model‐independent.
Linking negative herding effect to online public opinion: A new BiGADG approach for sentiment classification
Authors: Zhou Yiyin , Hu Yanrong , Liu Hongjiu , Huang Ping , Dai Dan 
Published: March 2024

AbstractThe negative herding effect tends to cause the spread of negative emotions among netizens, resulting in significant public opinion crises. Therefore, linking the negative herding effect and online public opinion, we aim to exploring the connection between netizens' emotions, opinions, and the negative herding effect. To better distinguish the emotions in texts, a new BiGADG (Bidirectional Gated recurrent unit based on Attention with Distance‐based dependency syntax Graph convolutional network) model is proposed in this article. This model includes primarily the proposed dependency syntax based on dependency distance, Bidirectional Gated Recurrent Unit (BiGRU), multi‐head self‐attention and Graph Convolutional Network (GCN). Particularly, the dependency syntax based on dependency distances incorporates word‐to‐word dependency distances into the traditional dependency syntax, which enriches the syntactic structural features of the text. After the experiments, the accuracy of BiGADG model is 86.53%, which is 3.11% higher compared to BERT model. It is evident that our model for sentiment classification has been improved. Based on the results of sentiment classification, we investigate the existence of negative herding behaviour and its underlying motivation in online public opinion. We have found that the negative herding effect, if not effectively managed, may trigger large‐scale and uncontrollable public opinion crises.
Setting the context for a complex dental intervention of role substitution in care homes: Initial process evaluation findings
Authors: Hendry Annie , Baker Sarah R. , McKenna Gerry , Tsakos Georgios , Chestnutt Ivor , Smith Craig , Jones Vicki , O'Neill Ciaran , Jenkins Alison , Evans Rachel , Syed Saif Sayeed , Mirza Afshan , Harvey Michelle , Karki Anup , Moons Kirstie , Sandom Fiona , Donaldson Michael , Lappin Caroline , Shepherd Karen , Brocklehurst Paul R. 
Published: March 2024

ObjectivesSENIOR (uSing rolE‐substitutioN In care homes to improve oRal health) is a randomised controlled trial designed to determine whether role substitution could improve oral health for this population. A parallel process evaluation was undertaken to understand context. This paper reports on the first phase of the process evaluation.BackgroundThe oral health and quality‐of‐life of older adults residing in care homes is poorer than those in the community. Oral health care provision is often unavailable and a concern and challenge for managers. The use of Dental Therapists and Dental Nurses rather than dentists could potentially meet these needs.Materials and MethodsSemi‐structured interviews were conducted with 21 key stakeholders who either worked or had experience of dependent care settings. Questions were theoretically informed by the: Promoting Action on Research Implementation in Health Services (PAHRIS) framework. The focus was on contextual factors that could influence adoption in practice and the pathway‐to‐impact. Interviews were fully transcribed and analysed thematically.ResultsThree themes (receptive context, culture, and leadership) and 11 codes were generated. Data show the complexity of the setting and contextual factors that may work as barriers and facilitators to intervention delivery. Managers are aware of the issues regarding oral health and seek to provide best care, but face many challenges including staff turnover, time pressures, competing needs, access to services, and financial constraints. Dental professionals recognise the need for improvement and view role substitution as a viable alternative to current practice.ConclusionAlthough role substitution could potentially meet the needs of this population, an in‐depth understanding of contextual factors appeared important in understanding intervention delivery and implementation.
Haemophilia in the era of novel therapies: Where do inhibitors feature in the new landscape?
Authors: Meeks Shannon L. , Zimowski Karen L. 
Published: March 2024

AbstractIntroductionThe advent of therapeutic recombinant factor VIII (FVIII) and factor IX (FIX) protein infusions revolutionized the care of persons with haemophilia in the 1990s. It kicked off an era with the increasing use of prophylactic factor infusions for patients and transformed conversations around the ideal trough activity levels as well as the ultimate goals in tailored, individualized care. Our knowledge surrounding the immunologic basis of inhibitor development and treatment derives from a time when patients were receiving frequent factor infusions and focused on immune tolerance induction following inhibitor development.DiscussionMore recently, care was revolutionized again in haemophilia A with the approval of emicizumab, a bispecific antibody mimicking activated FVIII function, to prevent bleeding. The use of emicizumab prophylaxis has resulted in a significantly slower accumulation of factor exposure days and continued effective prophylaxis in the case of inhibitor development. While emicizumab is effective at reducing the frequency of bleeding events in patients with haemophilia A, management of breakthrough bleeds, trauma, and surgeries still requires additional treatment. Ensuring that FVIII is a therapeutic option, particularly for life‐threatening bleeding events and major surgeries is critical to optimizing the care of persons with haemophilia A. Other novel non‐factor concentrate therapies, including rebalancing agents, will dramatically change the landscape for persons with haemophilia B with inhibitors.ConclusionThis review discusses the changing landscape regarding the timing of inhibitor development and management strategies after inhibitor development, stressing the importance of education across the community to continue to vigilantly monitor for inhibitors and be prepared to treat persons with inhibitors.
Value of autotaxin for hepatocellular carcinoma risk assessment in chronic hepatitis B patients treated with nucleos(t)ide analogs
Authors: Hiyama Yuichi , Fujino Hatsue , Namba Maiko , Fujii Yasutoshi , Uchikawa Shinsuke , Ono Atsushi , Nakahara Takashi , Murakami Eisuke , Kawaoka Tomokazu , Miki Daiki , Tsuge Masataka , Oka Shiro 
Published: March 2024

AbstractAimAutotaxin (ATX) is a newly identified liver fibrosis biomarker; however, its clinical usefulness remains unclear. Therefore, we analyzed the changes in patients with chronic hepatitis B virus infection treated with nucleos(t)ide analogs (NAs) to evaluate its usefulness. We also investigated the predictors of hepatocellular carcinoma development, including ATX, in patients with chronic hepatitis B based on their clinical characteristics.MethodsThis retrospective study included 179 patients with hepatitis B virus infection treated with NAs for >2 years. First, we measured the ATX levels before and up to 10 years after initiating entecavir (therapy for 88 patients whose serial ATX levels could be measured before and during entecavir therapy. Subsequently, for 179 patients whose ATX levels could be measured at the commencement of NAs, we examined the factors involved in developing hepatocellular carcinoma, including ATX.ResultsThe ATX levels showed a gradual and significant decrease during the observation period of up to 10 years. Multivariable analysis showed that a baseline ATX/upper limits of normal ratio ≥1.214, age, and alkaline phosphatase levels were independent risk factors for hepatocellular carcinoma development. The combination of age and ATX/upper limits of normal ratio was used to stratify the high‐risk groups for liver carcinogenesis.ConclusionsA decrease in ATX levels up to 10 years after the commencement of therapy suggested that ATX is a helpful biomarker in evaluating fibrosis in patients undergoing long‐term NA therapy. Furthermore, this study showed that combining age and the baseline ATX/upper limits of normal ratio may help identify high‐risk carcinogenesis groups.
Real‐world efficacy of 2% crisaborole ointment on chronic hyperplasia lesions in 49 patients with atopic dermatitis
Authors: Ma Chuan , Sun Jiachen , Liu Zilian , Zhang Chunlei 
Published: March 2024

AbstractBackgroundCrisaborole, as a phosphodiesterase 4 (PDE4) inhibitor (PDE4i), effectively inhibits inflammatory pathways, showing promising results in atopic dermatitis (AD), particularly in chronic hyperplasia lesions.ObjectivesBased on real‐world data from China, this study assesses the effectiveness and safety of 2% PDE4i ointment as monotherapy for chronic hyperplastic AD lesions.Materials and methodsA total of 49 AD patients aged 12 and above with chronic hyperplastic lesions and Investigator's Static Global Assessment scores of mild or moderate were enrolled. They received 2% PDE4i ointment twice daily until the lesions completely cleared. The effectiveness endpoints comprised the onset time of pruritus and lesion remission and the time of complete lesion clearance.ResultsPDE4i demonstrated high effectiveness with minimal irritation, notable improvement in hyperpigmentation, and early remission of pruritus and lesions. The response varied across age groups; elderly patients experienced quicker pruritus relief compared to adolescents and adults, while adolescents showed earlier lesion remission by about 3 days. No significant difference was observed across age groups in the time for complete lesion clearance. Additionally, AD duration (less or more than 3 years) did not significantly impact pruritus or lesion remission.ConclusionsPDE4i monotherapy is effective and safe for chronic hyperplasia lesions in AD across all age groups, and its effectiveness appears to be independent of AD duration.
Mechanism of programmed cell death in the posterior silk gland of the silkworm, Bombyx mori, during pupation based on Ca2+ homeostasis
Authors: Gu Haoyi , Zou Hongbin , Cheng Jialu , Liu Xiaohan , Jiang Zhe , Peng Peilin , Li Fanchi , Li Bing 
Published: March 2024

AbstractThe silkworm, Bombyx mori, is a complete metamorphosed economic insect, and the silk gland is a significant organ for silk protein synthesis and secretion. The silk gland completely degenerates during pupation, but the regulatory mechanism of programmed cell death (PCD) has not yet been understood. In the present study, we investigated the non‐genetic pathway of 20E‐induced PCD in the posterior silk gland (PSG) based on intracellular Ca2+ levels. Silk gland morphology and silk gland index indicated rapid degeneration of silk gland during metamorphosis from mature silkworm (MS) to pupal day 1 (P1), and Ca2+ levels within the PSG were found to peak during the pre‐pupal day 1 (PP1) stage. Moreover, the results of autophagy and apoptosis levels within the PSG showed that autophagy was significantly increased in MS‐PP1 periods, and significantly decreased in PP2 and P1 periods. Apoptosis was almost absent in MS‐PP1 periods and significantly increased in PP2 and P1 periods. Additionally, western blotting results showed that autophagy preceded apoptosis, and the autophagy‐promoting ATG5 was cleaved by calpain to the autophagy‐inhibiting and apoptosis‐promoting NtATG5 since PP1 period, while decreased autophagy was accompanied by increased apoptosis. Collectively, these findings suggest that Ca2+ is a key factor in the shift from autophagy to apoptosis.
GLP‐1 receptor agonists alleviate colonic inflammation by modulating intestinal microbiota and the function of group 3 innate lymphoid cells
Authors: Sun Hanxiao , Shu Jie , Tang Jupei , Li Yue , Qiu Jinxin , Ding Zhaoyun , Xuan Binbin , Chen Minghui , Gan Chenxin , Lin Jinpiao , Qiu Ju , Sheng Huiming , Wang Chuanxin 
Published: March 2024

AbstractGlucagon‐like peptide‐1 receptor agonists (GLP‐1RAs), which are drugs used for treating type 2 diabetes, have been reported to exert anti‐inflammatory effects on inflammatory bowel disease (IBD), the mechanism of which remains elusive. Here, we report that GLP‐1RAs ameliorate dextran sulfate sodium (DSS)‐induced colitis in both wild‐type and T/B‐cell‐deficient mice through modulating group 3 innate lymphoid cells (ILC3s), a subset of innate lymphoid cells that regulate intestinal immunity. GLP‐1RAs promote IL‐22 production by ILC3, and the protective effect of GLP‐1RAs on DSS‐induced colitis was abrogated in ILC3‐deficient RORgtgfp/gfp mice. Furthermore, the treatment effect of GLP‐RAs on colitis, as well as the generation of IL‐22‐producing ILC3s by GLP‐RAs, is dependent on the gut microbiota. GLP‐1RAs increase the abundance of Firmicutes and Proteobacteria in the gut, particularly beneficial bacteria such as Lactobacillus reuteri, and decrease the abundance of enteropathogenic Staphylococcus bacteria. The untargeted gas chromatography (GC)/liquid chromatography (LC)‐mass spectrometry (MS) of faecal metabolites further revealed enrichment of N,N‐dimethylsphingosine (DMS), an endogenous metabolite derived from sphingosine, in the GLP‐1RA‐treated group. Strikingly, DMS ameliorates colitis while promoting intestinal IL‐22‐producing ILC3s. Taken together, our findings show that GLP‐1RAs exert a therapeutic effect on colitis possibly by regulating the microbiota‐DMS‐IL‐22+ILC3 axis, highlighting the potential beneficial role of GLP‐RAs in inflammatory intestinal disorders with diabetes complications.
RETRACTED: Risk factors for amputation in diabetic foot ulcers: A retrospective analysis
Authors: Zhang Xiaoyu , Li Qiwei , Zhou Xianpei , Xu Yu , Shu Zizhen , Deng Hongyu 
Published: March 2024

AbstractDiabetic foot ulcers (DFUs) are chronic, difficult‐to‐heal wounds with a very high incidence of amputation. For patients with DFUs, prevention of amputation is crucial. However, the risk factors associated with DFU amputation and the extent to which different risk factors increase the risk of amputation are still uncertain. This study intends to provide a clinical basis for early intervention in DFU by retrospectively analysing the risk factors for DFU amputation. A retrospective analysis of 200 patients with DFUs admitted between October 2019 and October 2023 was conducted. Sixty‐eight of the 200 underwent amputations. The overall amputation rate was 34%. Multiple logistic regression model showed that neutrophil/lymphocyte ratio (OR = 1.943; 95% CI:1.826–2.139), white blood cell (OR = 1.143; 95% CI:1.034–1.267), C‐reactive protein (OR = 1.307; 95% CI:1.113–2.194) and Wagner grading (OR = 2.783; 95% CI: 1.751–4.302) were independent risk factors for amputation, while haemoglobin (OR = 0.742; 95% CI:0.638–0.965) and high density lipoprotein were independent protective factors for amputation (OR = 0.168; 95% CI:0.037–0.716), and further Receiver Operating Characteristic Curve curves showed that they showed high accuracy and were good predictors of amputation of DFUs.