bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ten Years of Experience on the Effectiveness and Efficiency of the Cleanfield Device in Cardiothoracic Surgery
Authors: Condello Ignazio 
Published: March 2024

Abstract
The process of blood management and treatment from the surgical field to produce concentrated red blood cells (RBC) is crucial in the context of cardiothoracic surgery and in other branch of surgery. The role of autotransfusion reservoir is not well described in the literature in terms of superiority suction for hemolysis prevention. In this context, we presented a ten-year single-center retrospective analysis on suction, filtering, and blood collection from surgical field through the use of the Cleanfield Autotransfusion Reservoir (Eurosets SRL, Medolla, Italy) in terms of performance, effectiveness, and safety. From January 2013 to January 2023 were collected and analyzed the consecutive uses of Cleanfield Autotransfusion Reservoir in a single cardiothoracic surgery center Anthea Hospital Gvm Care & Research, Bari, Italy. For single procedure, the number of cleanfield disposable used, the relative maximum blood volume filtered and collected, the suction pressure from devices through vacuum meter and the electronic suction pressure measurements in the devices for suctions and the presence and the incidence of adverse events during the use (implosion, clot formation, inability to cell saver use, inability to suction during the use) were analyzed. 5202 Cleanfield disposable autotransfusion reservoir were analyzed for blood volume suction, filtering and collection on 5199 cardiac surgery procedures, the maximum blood volume filtered and collected was 1997 ± 123 ml, the mean suction pressure measured from the device with vacuum meter during suction use was 38 ± 3 mmHg, the mean suction pressure measured in the device during suction use was 38 ± 2 mmHg, no presence of adverse event was reported for implosion, clot formation, inability to cell saver use, and inability to suction during the use. In our retrospective report, the use of Cleanfield autotransfusion reservoir (Eurosets SRL, Medolla Italy) in cardiothoracic surgery context was safe and effective for blood volume suction, filtering, and collection.
SOCRATES THE EUTRAPELOS: XENOPHON AND ARISTOTLE ON ETHICAL VIRTUE
Authors: Danzig Gabriel 
Published: March 2024

AbstractThe social virtues are not discussed thematically in the Socratic writings of Plato and Xenophon, but they are on display everywhere. Taking Aristotle's accounts of these virtues as a touchstone, this paper explores the portrait of Socrates as a model of good humour in Xenophon's Symposium. While Xenophon is addressing the same issues as Aristotle, and shares some of his red lines, his conception of the ideal humourist and of virtue in general differs from Aristotle's not only in detail but also in general conception. While he never actually violates the rules Aristotle sets down for eutrapelia, Xenophon's Socrates strives not to avoid opposites but to combine them. It is the careful combining of the spoudaion and the geloion that redeems Xenophon's otherwise outrageous portrait of Socratic humour. This suggests a broader paradigm in which virtuous behaviour is a combination of opposites rather than a middle path.
Irish-American Anti-Imperialism in Patrick Ford’s The Criminal History of the British Empire
Authors: O’Sullivan Robert 
Published: March 2024

AbstractIn 1881, Patrick Ford, the Irish-American nationalist editor of the New York Irish newspaper The Irish World and American Industrial Liberator, published The criminal history of the British empire, a collection of five letters that he had written to William Gladstone. In The criminal history, Ford constructed a comprehensive account of British imperial history, beginning with England’s conquest of Ireland, before detailing the colonization of North America, Britain’s participation in the transatlantic slave trade, the American Revolution, British rule in India, the opium wars, and Britain’s contemporary colonization of Africa. This article contributes to scholarship on American views of the British empire in the post-bellum United States. In exploring how Ford constructed a Manichean interpretation of world history, where the British imperial project devastated every region it invaded, the article analyses Ford’s reasons for writing and publishing the letters that formed The criminal history. Finally, the article shows that Ford’s central purpose was to foster a visceral hatred of the British empire among his Irish-American readership, to maintain a commitment to their ethnic heritage as proud Irish people, and to encourage his readers that a better future would soon arrive, when the British empire was finally a relic of the past.
Abnormal symmetric chelipeds in an specimen of snapping shrimp Synalpheus fritzmuelleri Coutiere, 1909
Authors: Moraes Isabela Ribeiro Rocha , Zacari Larissa , Santos Rafael de Carvalho , Rodrigues Gabriel Fellipe Barros , Castilho Antonio Leão 
Published: March 2024

Abstract
Morphological symmetry abnormalities in cheliped appendages of alpheid shrimps are extremely rare and poorly recorded in the literature. A symmetric minor cheliped were, for example, observed in queen females belonging to Synalpheus eusocial species. Symmetric major chelipeds were now described in Synalpheus fritzmuelleri individuals living in shallow Brazilian waters. These individuals were found in symbiotic association with the bryozoan Schizoporella sp. (biogenic substrate) adhering to the pilings of Ubatuba Bay docks, São Paulo State. Only one of 20 sampled S. fritzmuelleri individuals presented anomalous symmetric chelipeds. Based on carapace length, size, and morphological features, the analyzed specimens seemed to be juvenile; thus, the hypothesis of anomalous condition can be directly linked to genetic inhibition of the mechanism accounting for major cheliped development in this ontogeny phase. Studies like the present one often provide remarkable information on animal morphology and can be used as reference in evolutionary assessments to be conducted in the future.
First occurrence of ophiuroid-parasitic genus Ophieulima (Mollusca: Gastropoda: Eulimidae) in the North Pacific Ocean
Authors: Takano Tsuyoshi , Kohtsuka Hisanori , Okanishi Masanori 
Published: March 2024

Abstract
A eulimid gastropod of the genus Ophieulima, parasitic on the disc of the ophiactid brittle star Ophiactis dyscrita, was collected from 256–343 m deep off Kanagawa, central Japan. This represents the first record of the genus from Japanese waters and even from the North Pacific Ocean. Here we describe it as Ophieulima yoshiharai n. sp. The generic assignment is justified by its conchological characters including (1) a small, conical shape with convex teleoconch whorls, (2) many fine growth lines and some strong growth pause scars on the teleoconch, (3) a well-developed, twisted columella, and (4) a multispiral, brownish transparent protoconch. Ophieulima yoshiharai n. sp. is distinguishable from the three (two named and one undescribed) extant, as well as two fossil congeners by its slender shell with the length of 2.1 times larger than width, a small aperture and a protoconch of 3.5 whorls. The new species is also characterized by its bathymetric distribution, which is shallower than the extant species of Ophieulima. On the other hand, the hosts of Ophieulima species are so far restricted to ophiuroids of the genus Ophiactis and the three named species have mostly been found attached to the lateral and/or dorsal sides of the host's disc, suggesting their similar parasitic ecology.
Description of a new Luidia species (Asteroidea: Paxillosida: Luidiidae) from Japan with molecular phylogenetic analysis of the genus Luidia
Authors: Kobayashi Itaru , Hibino Mai , Yamamoto Masaki , Fujita Toshihiko 
Published: March 2024

Abstract
Luidia iwakiensis n. sp. (Asteroidea, Echinodermata) is described in Japanese waters. A molecular phylogenetic analysis including 18 Luidia species supported Döderlein L (1920, Siboga Expedition 4, 193–291) four morphogroups. Morphological reconsideration revealed three of the eight criteria of the morphogroup adopted by Döderlein were justified, but the remaining five characters were rejected. The placement of the new species in the Ciliaris-group was supported by molecular as well as morphological evidence, however, it varies from other species of Ciliaris-group by arm number, length of major inferomarginal spines, and pedicellariae on actinal plates.
Impact of obstructive sleep apnoea on cardiovascular outcomes and mortality in young adults with congenital heart anomalies: insights from the national inpatient sample (2019)
Authors: Vyas Ankit , Desai Rupak , Ghadge Nitin , Bansal Prerna , Chintalapalli Patta Harika Varma , Raval Maharshi , Jain Akhil , Gupta Tripti , Patel Harshil , Kondur Ashok , Lavie Carl J. 
Published: March 2024

AbstractBackground:Obstructive sleep apnoea is a common sleep disorder, and adult congenital heart disease (CHD) is also a significant burden on the population. Early diagnosis and treatment are important for improving quality of life and reducing the risk of health complications. The limited research on obstructive sleep apnoea and adult CHD highlights the need for further investigation into the relationship between these two conditions and the mechanisms underlying this relationship.Method:We used NIS 2019 database to identify adult CHD admissions aged 18–44 years and assess the impact of obstructive sleep apnoea on all-cause mortality, dysrhythmia, and stroke. A propensity-matched cohort of individuals with and without obstructive sleep apnoea was obtained, and the outcomes were assessed using multivariable analysis and compared in terms of resource utilisation.Results:Of the 41,950 young adult CHD admissions, 6.3% (n = 2630) had obstructive sleep apnoea. The obstructive sleep apnoea+ (n = 2590) and obstructive sleep apnoea− (n = 2590) cohorts were comparable in terms of median age (35 years) and were predominantly male (63.1% versus 62.5%). The obstructive sleep apnoea+ cohort had a higher frequency of risk factors like chronic obstructive pulmonary disease, hypothyroidism, and prior venous thromboembolism than the obstructive sleep apnoea cohort. We found significant association of obstructive sleep apnoea with dysrhythmia (adjusted odds ratio 2.99, 95% confidence interval 2.13–4.19, p < 0.001), but no significant impact on the risk of all-cause mortality or stroke. The obstructive sleep apnoea+ cohort also had higher transfers to short-term facilities, prolonged stays, and higher charges (p < 0.001).Conclusion:Our study provides important insights into relationship between obstructive sleep apnoea and adult CHD and highlights the need for further investigation into the impact of obstructive sleep apnoea on individuals with adult CHD.
A Lake Record of Geomagnetic Secular Variations for the Last 23 ka From Lake Chala: Toward a Composite Directional Lake Record of the Earth's Magnetic Field for Equatorial East Africa
Authors: Di Chiara A. , Hounslow M. W. , Maher B. A. , Karloukovski V. , Van Daele M. , Blaauw M. , Verschuren D. 
Published: March 2024

AbstractThe documentation and understanding of variations in the Earth's magnetic field through time is fundamental for several disciplines, but current geomagnetic models rely on datasets heavily biased toward the mid‐ and high northern latitudes. The African continent and surrounding islands and oceans are particularly underrepresented. Here, we present a new record of paleo‐secular variation (PSV) of the inclinations over the last 23 ka from Lake Chala, situated at 3°S near Mt Kilimanjaro in eastern equatorial Africa. This groundwater‐fed crater lake is characterized by a high sedimentation rate (ca. 1 cm/10 years) and a particularly well‐constrained age model based on 210Pb and 14C dating. The magnetic mineralogy of the sediments is tested with rock magnetic analyses. The Lake Chala inclination record shows four highs and lows over 20 ka and compares well with that of Lake Malawi (10°S) between 20 and 16.2 ka, and from 9.8 to 2.6 ka. This record is linked to PSV records at Lakes Victoria and Malawi using a sequence slotting technique to generate a composite PSV model for east Africa. Analyzed at best‐possible resolutions up to 200 years, the Lake Chala PSV record not only represents an important contribution to improve our understanding of local and global features of the Earth's magnetic field. It also expands the utility of paleomagnetism as a key tool for dating and correlation both for archeological sites throughout East Africa and the many volcanoes, active or dormant, of the East African Rift System.
Terrane Collision‐Induced Subduction Initiation: Mode Selection and Implications for Western Pacific Subduction System
Authors: Cui Fengyuan , Li Zhong‐Hai 
Published: March 2024

AbstractIn the regime of plate tectonics, the subduction of an oceanic plate generally terminates with the collision and accretion of continental terranes. Then, a new subduction zone may form in the neighboring oceanic plates, which is defined as the terrane collision‐induced subduction initiation (SI). Based on the analyses of the western Pacific subduction system in the Cenozoic, three types of collision‐induced SI have been observed: subduction polarity reversal, subduction transference and far‐field subduction. However, the dynamics and controlling factors of SI mode selection after terrane collision are not clear. In this study, a multi‐terrane collision model has been conducted with variable rheological strength of continental terranes and different convergence velocities. The model results indicate that the relative strength of the terranes controls the SI mode selection, with the new subduction zone tending to form beneath weaker terranes. In addition, the higher convergence velocity can facilitate the collision‐induced SI. An analytical study of force balance has been further conducted, which provides a mechanical explanation for the numerical prediction of a weak overriding terrane as a favorable SI site. The numerical models and force balance analyses are further compared with the natural cases in the western Pacific subduction system. This indicates that subduction polarity reversal is the most favorable mode after terrane collision in the western Pacific, possibly due to the weakness of overriding plate during the preceding subduction‐induced fluid/melt activity. This comprehensive study provides systematic constraints for the dynamics of collision‐induced subduction jump, especially for the western Pacific subduction zones in the Cenozoic.
Multiple Exhumation Stages During the Cenozoic Evolution of the Northeast Tibetan Plateau
Authors: Wang Xiuxi , Zattin Massimiliano , Yang Yu , Tao Jia , Liu Huiming , Zhang Yanbo , Wang Hong , Pang Bozhong , Wang Linbing , Ji Minxiao 
Published: March 2024

AbstractThe Cenozoic growth history of the northeast (NE) Tibetan Plateau has been strongly debated in the past few years with three deformation models being proposed: progressive northeastward propagation, out‐of‐sequence deformation, and episodic deformation. Reconstruction of the long‐term deformation and exhumation history of the different blocks can help elucidate the growth pattern and tectonic processes involved in the formation of the Plateau. Both the Qaidam and Jiuquan basins—the two largest basins of the NE Tibetan Plateau—contain continuous and well‐exposed successions of synorogenic sediments that span the entire Cenozoic. We used apatite fission‐track thermochronology, sedimentary facies, and structural and provenance analyses of these successions to determine the exhumation history of the Tibetan Plateau. Five distinct fast exhumation events were recognized and dated: 65–54, 43–39, 34–29, 24–21, and 16–15 Ma. Comparison with existing morphotectonic information enabled us to reconstruct a multiple‐stage growth scenario for the NE Tibetan Plateau in the context of the surface uplift phases across the Himalayan‐Tibetan orogen during the Cenozoic. Overall, our findings support the episodic deformation model and emphasizes that the current relief of the NE Tibetan Plateau is largely derived from these five of stage of exhumation.
5G2 mutant mice model loss of a commonly deleted segment of chromosome 7q22 in myeloid malignancies
Authors: Wong Jasmine C. , Weinfurtner Kelley M. , Westover Tamara , Kim Jangkyung , Lebish Eric J. , del pilar Alzamora Maria , Huang Benjamin J. , Walsh Michael , Abdelhamed Sherif , Ma Jing , Klco Jeffery M. , Shannon Kevin 
Published: March 2024

AbstractMonosomy 7 and del(7q) are among the most common and poorly understood genetic alterations in myelodysplastic neoplasms and acute myeloid leukemia. Chromosome band 7q22 is a minimally deleted segment in myeloid malignancies with a del(7q). However, the rarity of “second hit” mutations supports the idea that del(7q22) represents a contiguous gene syndrome. We generated mice harboring a 1.5 Mb germline deletion of chromosome band 5G2 syntenic to human 7q22 that removes Cux1 and 27 additional genes. Hematopoiesis is perturbed in 5G2+/del mice but they do not spontaneously develop hematologic disease. Whereas alkylator exposure modestly accelerated tumor development, the 5G2 deletion did not cooperate with KrasG12D, NrasG12D, or the MOL4070LTR retrovirus in leukemogenesis. 5G2+/del mice are a novel platform for interrogating the role of hemopoietic stem cell attrition/stress, cooperating mutations, genotoxins, and inflammation in myeloid malignancies characterized by monosomy 7/del(7q).
tiRNA-Val-CAC-2 interacts with FUBP1 to promote pancreatic cancer metastasis by activating c‑MYC transcription
Authors: Xiong Qunli , Zhang Yaguang , Xu Yongfeng , Yang Yang , Zhang Zhiwei , Zhou Ying , Zhang Su , Zhou Lian , Wan Xiaowen , Yang Xiaojuan , Zeng Zhu , Liu Jinlu , Zheng Ying , Han Junhong , Zhu Qing 
Published: March 2024

AbstractCumulative studies have established the significance of transfer RNA-derived small RNA (tsRNA) in tumorigenesis and progression. Nevertheless, its function and mechanism in pancreatic cancer metastasis remain largely unclear. Here, we screened and identified tiRNA-Val-CAC-2 as highly expressed in pancreatic cancer metastasis samples by tsRNA sequencing. We also observed elevated levels of tiRNA-Val-CAC-2 in the serum of pancreatic cancer patients who developed metastasis, and patients with high levels of tiRNA-Val-CAC-2 exhibited a worse prognosis. Additionally, knockdown of tiRNA-Val-CAC-2 inhibited the metastasis of pancreatic cancer in vivo and in vitro, while overexpression of tiRNA-Val-CAC-2 promoted the metastasis of pancreatic cancer. Mechanically, we discovered that tiRNA-Val-CAC-2 interacts with FUBP1, leading to enhanced stability of FUBP1 protein and increased FUBP1 enrichment in the c-MYC promoter region, thereby boosting the transcription of c-MYC. Of note, rescue experiments confirmed that tiRNA-Val-CAC-2 could influence pancreatic cancer metastasis via FUBP1-mediated c-MYC transcription. These findings highlight a potential novel mechanism underlying pancreatic cancer metastasis, and suggest that both tiRNA-Val-CAC-2 and FUBP1 could serve as promising prognostic biomarkers and potential therapeutic targets for pancreatic cancer.
Temperature probe placement in very preterm infants during delivery room stabilization: an open-label randomized trial
Authors: Jani Pranav R. , Maheshwari Rajesh , Skelton Hannah , Viola Patricia , Thomas Sheela , Ryder Lynette , Culcer Mihaela , Mishra Umesh , Shah Swapnil , Baird Jane , Elhindi James , Padernia Ann-Maree , Goyen Traci-Anne , D’Cruz Daphne , Luig Melissa , Shah Dharmesh 
Published: March 2024

Abstract
Background
Variation in practice exists for temperature probe positioning during stabilization of very preterm infants (<32 weeks gestation). We explored the influence of temperature probe sites on thermoregulation.

Methods
An open-label, stratified, balanced, parallel, randomized trial was conducted. Inborn infants were randomly assigned temperature probe to the axilla or to the upper back. The primary outcome was normothermia (local range: 36.8–37.3 °C and World Health Organization (WHO) range: 36.5–37.5 °C) at admission to the neonatal intensive care unit.

Results
Between 1 November 2018 and 4 July 2022, 178 infants were randomly assigned to one of the two sites (n = 89 each), 175 included in the final analysis. Normothermia (local range) was achieved for 39/87 infants (44.8%) assigned to the upper back compared to 28/88 infants (31.8%) assigned to the axilla [risk difference:13%; 95% CI −1.3–27.3]. Normothermia (WHO range) was achieved for 78/87 infants (89.7%) assigned to the upper back compared to 70/88 infants (79.6%) assigned to the axilla [risk difference:10.1%; 95% CI −0.5–20.7]. No infant recorded temperatures >38 °C or developed skin injury.

Conclusions
In very preterm infants, upper back site was equally effective as the axilla in maintaining normothermia, with no increase in adverse events.

Clinical trial registration
The study was registered with the Australian New Zealand Clinical Trials Registry (ACTRN12620000293965).

Impact

Substantial variation in practice exists for the site of securing a temperature probe during delivery room stabilization of very preterm infants and the influence of temperature probe site on thermoregulation remains unknown.

In this study, upper back site was equally effective as the axilla in maintaining normothermia, with no increase in adverse events.

Clinicians could adopt upper back site for maintaining normothermia.

This study may contribute data to future international participant data prospective meta analysis of randomized controlled trials worldwide on temperature probe positioning in very preterm infants, increasing translation of research findings to optimize thermoregulation and clinical outcomes.
Being precise with anticoagulation to reduce adverse drug reactions: are we there yet?
Authors: Cross Benjamin , Turner Richard M. , Zhang J. Eunice , Pirmohamed Munir 
Published: March 2024

AbstractAnticoagulants are potent therapeutics widely used in medical and surgical settings, and the amount spent on anticoagulation is rising. Although warfarin remains a widely prescribed oral anticoagulant, prescriptions of direct oral anticoagulants (DOACs) have increased rapidly. Heparin-based parenteral anticoagulants include both unfractionated and low molecular weight heparins (LMWHs). In clinical practice, anticoagulants are generally well tolerated, although interindividual variability in response is apparent. This variability in anticoagulant response can lead to serious incident thrombosis, haemorrhage and off-target adverse reactions such as heparin-induced thrombocytopaenia (HIT). This review seeks to highlight the genetic, environmental and clinical factors associated with variability in anticoagulant response, and review the current evidence base for tailoring the drug, dose, and/or monitoring decisions to identified patient subgroups to improve anticoagulant safety. Areas that would benefit from further research are also identified. Validated variants in VKORC1, CYP2C9 and CYP4F2 constitute biomarkers for differential warfarin response and genotype-informed warfarin dosing has been shown to reduce adverse clinical events. Polymorphisms in CES1 appear relevant to dabigatran exposure but the genetic studies focusing on clinical outcomes such as bleeding are sparse. The influence of body weight on LMWH response merits further attention, as does the relationship between anti-Xa levels and clinical outcomes. Ultimately, safe and effective anticoagulation requires both a deeper parsing of factors contributing to variable response, and further prospective studies to determine optimal therapeutic strategies in identified higher risk subgroups.