bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pemanfaatan Ruang Baca Dalam Meningkatkan Pengetahuan Anak-Anak Usia 6-12 Tahun Di Desa Liya One Melangka Wakatobi
Authors: Nurhalizah Dina , Novandy Hartanto , Anggun Mustika , Nur Putri Mawaddah , Zawulan Zawulan , Kartini Kartini 
Published: March 2024

Membaca memiliki berbagai manfaat yang sangat penting untuk perkembangan personal, intelektual, dan emosional seseorang. Membaca tidak hanya memberikan manfaat saat ini, tetapi juga membentuk individu untuk pertumbuhan jangka panjang. Kegiatan ini bertujuan untuk meningkatkan pengetahuan mereka dalam pelajaran Bahasa Inggris, Matematika, belajar Mengaji, dan mewarnai. Metode yang digunakan dalam pengabdian ini adalah penyampaian materi, dengan tahapan tahapan: Observasi, Pembentukan team, persiapan, pengabdian dan evualuasi. Hasil dari pengabdian ini menunjukan bahwa kegiatan kursus (Ruang Baca) (ruang baca) memiliki dampak positif dalam meningkatkan pengetahuan anak-anak dalam pelajaran Bahasa Inggris, Matematika, dan Mengaji di desa Liya Onemelangka. Hal ini bisa dilihat dari hasil pembelajaran kursus (Ruang Baca) seperti meningkatnya kosa kata bahasa inggris anak-anak, kemampuan menghitung anak-anak, pelafalan huruf hijaiyah anak-anak, dan meningkatkan kreatifitas anak-anak dalam mewarnai.Kata kunci: Kursus (Ruang Baca), anak-anak Desa Liya Onemelangka.
ANALISIS RISIKO KECELAKAAN KERJA PADA BAGIAN PRODUKSI CV. JAYA ABADI MENGGUNAKAN METODE JOB SAFETY ANALYSIS (JSA)
Authors: Rizki Moh , Jufriyanto Moh , Hidayat Hidayat 
Published: March 2024

Faktor penunjang keberhasiIan suatu industri ditentukan dari keIancaran pada saat proses produksi. CV. Jaya Abadi adaIah perusahaan bergerak di bidang manufaktur kayu potong. ApabiIa proses produksi berjaIan Iancar, maka penggunaan mesin dan peraIatan produksi yang efektif akan menghasiIkan suatu produk yang berkuaIitas dan rendahnya produktivitas produksi akan mengakibatkan kerugian bagi perusahaan yang disebabkan oIeh penggunaan mesin/peraIatan yang tidak efektif dan efisien. DaIam kegiatan operasionaInya pekerja pada perusahaan ini banyak berhubungan Iangsung dengan mesin-mesin dan peraIatan serta Iingkungan kerja yang memiIiki risiko keceIakaan sangat tinggi. KeceIakaan kerja yang sering terjadi ada pada mesin bandsaw, pony dan crosscut. DaIam peneIitian ini, penuIis menggunakan metode Job Safety AnaIysis (JSA) yang kemudian didapatkan hasiI yaitu dari risiko potensi bahaya yang memiIiki kategori paIing tinggi, dapat diketahui penyebab dari timbuInya risiko bahaya yang terjadi.Kata Kunci: Manufaktur, Kayu Potong, Job Safety Anaiysis (JSA), Potensi Bahaya.
ANALISIS PENGUKURAN KERJA DALAM MENENTUKAN WAKTU STANDAR DENGAN METODE JAM HENTI PADA LINI PERAKITAN HARNESS VEND (AC/DC/WATARI) DI PT. FUJI METEC SEMARANG
Authors: Sutopo Lulus 
Published: March 2024

Tujuan dari penelitian ini adalah untuk mengetahui penggunaan metode jam henti pada pengukuran kerja pada lini perakitan Harness Vend(AC/DC/Watari) dan untuk mengetahui faktor apa saja yang digunakan dalam standar waktu kerja pengukuran dan untuk menentukan berapa banyak waktu standar yang dibutuhkan untuk proses perakitan Harness Vend (AC/DC/Watari). Pengumpulan data metode yang digunakan dalam penelitian ini adalah data primer yang diperoleh langsung dari pengukuran. Sedangkan metode analisis data menggunakan metode studi waktu jam henti. Hasil penelitian terdapat beberapa pekerja yang menggunakan waktu menganggur dan waktu pribadi lebih banyak dari waktu yang ditetapkan oleh perusahaan yaitu 12,5%, karena kurang pengawasan dan disiplin waktu kerja, faktor-faktor yang digunakan dalam bekerja pengukuran meliputi faktor penyesuaian (peringkat kinerja) dan faktor kelonggaran, hasil perhitungan waktu baku perakitan Harness sama dengan 1.143,54 detik atau 19,06 menit dan atau 0.32 jam. Kata Kunci: Pengukuran Waktu, Waktu Baku, Jam Henti, Kelonggaran.
EFEKTIVITAS DAN EFISIENSI SISTEM INFORMASI INVENTORY SPARE PART UTILITY VEHICLE HARNESS DI DEPARTEMEN ENGINERING PT. FUJI METEC
Authors: Wibowo Ricco Aprianto , Adhi Antono 
Published: March 2024

Era kemajuan teknologi seperti saat ini menuntut adanya efisiensi dan keefektifan dalam bekerja sehingga sistem informasi menjadi sebuah hal yang penting. Meski demikian, masih terdapat sebagian perusahaan yang masih menggunakan cara manual dalam mengelola barang yang masuk maupun keluar dari perusahaan, salah satunya adalah PT. Fuji Metec Semarang. Hal ini berimbas pada pengelolaan berbagai barang termasuk spare part pada PT. Fuji Metec Semarang karena tidak terintegrasi dan rekap penggunaan spare part tidak terdata dengan baik. Sistem informasi inventory ini dirancang berbasis website dengan menggunakan bahasa pemrograman PHP dan MySQL sebagai database-nya. Metode penelitian yang digunakan dalam penelitian ini adalah penelitian kuantitatif. Sistem informasi inventory terbukti efektif dan efisien untuk membantu para staf di Departemen Enginering PT. Fuji Metec dalam mengelola spare part utility vehicle harness. Efektivitas pengelolaan spare part utility vehicle harnessI. Di Departemen Enginering PT. Fuji Metec meningkat menyentuh hingga 86,7%. Kata Kunci: Sistem Informasi, Inventory, Spare Part, Harness
Rozważania o efektywności aktualnej karnej ochrony tajemnicy przedsiębiorstwa
Authors: Oczkowski Tomasz Edward 
Published: March 2024

Celem artykułu jest analiza znaczenia gospodarczego informacji stanowiących tajemnicę przedsiębiorstwa oraz omówienie szczególnej i odrębnej ochrony prawnej tej sfery dóbr niematerialnych. Akcentuje się rozbudowane w Polsce przepisy dotyczące tego zagadnienia, ujęte w przepisach mających na celu zwalczanie nieuczciwej konkurencji między przedsiębiorcami. Nieuprawnione posiadanie, ujawnienie lub wykorzystanie tajemnicy innego przedsiębiorstwa jest aktualnie odrębnym czynem z zakresu nieuczciwej konkurencji. Część z tych zachowań jest nawet kryminalizowana jako odrębne występki. I artykuł niniejszy wskazuje również na to, że ochrona karna przed tego rodzaju zachowaniami nie będzie w wielu sytuacjach efektywna, akcentując przyczyny tej oceny.
Pengaruh Kepatuhan Menjalani Rehabilitasi terhadap Peningkatan Kekuatan Otot Pada Pasien Pasca Stroke
Authors: Kasma  , Safei Imran , Zulfahmidah  , Rachman Moch. Erwin , Nasrudin Andi Mappaware  
Published: March 2024

Stroke adalah penyakit serebrovaskular yang dapat disebabkan karena tersumbatnya pembuluh darah di otak maupun karena pecahnya pembuluh darah yang dapat menyebabkan terjadinya kecacatan. Rehabilitasi dini dapat segera dilakukan setelah kondisi pasien stroke stabil. Latihan range of motion (ROM) merupakan salah satu latihan dalam proses rehabilitasi yang dinilai masih cukup efektif untuk mencegah terjadinya kecacatan pada pasien dengan stroke. Latihan yang terprogram akan mempengaruhi hasil yaitu tercapainya peningkatan kekuatan otot. Penelitian ini bertujuan untuk mengetahui bagaimana pengaruh kepatuhan menjalani rehabilitasi terhadap peningkatan kekuatan otot pada pasien pasca stroke melalui artikel sistematis review. Jenis penelitian ini menggunakan literature review dengan desain narrative review yaitu mencari artikel yang berhubungan dengan kepatuhan pasien stroke menjalani rehabilitasi terhadap peningkatan kekuatan otot yang telah dipublikasikan pada jurnal dari tahun 2017-2020. Jurnal dipilih berdasarkan kriteria inklusi dan eksklusi yang telah ditetapkan sebelumnya. Berdasarkan telaah dari 8 jurnal yang ada didapatkan hasil bahwa terjadi peningkatan kekuatan otot yang cukup signifikan pada pasien stroke yang rutin dan teratur menjalani rehabilitasi terutama pada fungsi motorik anggota gerak yang mengalami kelemahan atau kelumpuhan.
Predictive factors and the management of hyperglycemia in patients with acromegaly and Cushing’s disease receiving pasireotide treatment: post hoc analyses from the SOM230B2219 study
Authors: Feldt-Rasmussen Ulla , Bolanowski Marek , Zhang Shao-Ling , Yu Yerong , Witek Przemysław , Kalra Pramila , Kietsiriroje Noppadol , Piacentini Andrea , Pedroncelli Alberto M. , Samson Susan L. 
Published: March 2024

IntroductionPasireotide, a somatostatin receptor ligand, is approved for treating acromegaly and Cushing’s disease (CD). Hyperglycemia during treatment can occur because of the drug’s mechanism of action, although treatment discontinuation is rarely required. The prospective, randomized, Phase IV SOM230B2219 (NCT02060383) trial was designed to assess optimal management of pasireotide-associated hyperglycemia. Here, we investigated predictive factors for requiring antihyperglycemic medication during pasireotide treatment.MethodsParticipants with acromegaly or CD initiated long-acting pasireotide 40 mg/28 days intramuscularly (acromegaly) or pasireotide 600 μg subcutaneously twice daily during pre-randomization (≤16 weeks). Those who did not need antihyperglycemic medication, were managed with metformin, or received insulin from baseline entered an observational arm ending at 16 weeks. Those who required additional/alternative antihyperglycemic medication to metformin were randomized to incretin-based therapy or insulin for an additional 16 weeks. Logistic-regression analyses evaluated quantitative and qualitative factors for requiring antihyperglycemic medication during pre-randomization.ResultsOf 190 participants with acromegaly and 59 with CD, 88 and 15, respectively, did not need antihyperglycemic medication; most were aged &lt;40 years (acromegaly 62.5%, CD 86.7%), with baseline glycated hemoglobin (HbA1c) &lt;6.5% (&lt;48 mmol/mol; acromegaly 98.9%, CD 100%) and fasting plasma glucose (FPG) &lt;100 mg/dL (&lt;5.6 mmol/L; acromegaly 76.1%, CD 100%). By logistic regression, increasing baseline HbA1c (odds ratio [OR] 3.6; P=0.0162) and FPG (OR 1.0; P=0.0472) and history of diabetes/pre-diabetes (OR 3.0; P=0.0221) predicted receipt of antihyperglycemic medication in acromegaly participants; increasing baseline HbA1c (OR 12.6; P=0.0276) was also predictive in CD participants. Investigator-reported hyperglycemia-related adverse events were recorded in 47.9% and 54.2% of acromegaly and CD participants, respectively, mainly those with diabetes/pre-diabetes.ConclusionIncreasing age, HbA1c, and FPG and pre-diabetes/diabetes were associated with increased likelihood of requiring antihyperglycemic medication during pasireotide treatment. These risk factors may be used to identify those who need more vigilant monitoring to optimize outcomes during pasireotide treatment.
Relationship between blood cadmium levels and bone mineral density in adults: a cross-sectional study
Authors: Lei Yi , Guo Meiqian , Xie Juan , Liu Xueqing , Li Xiang , Wang Hongwu , Xu Yong , Zheng Donghui 
Published: March 2024

IntroductionOsteoporosis, a disease of reduced bone mass and microstructural deterioration leading to fragility fractures, is becoming more prevalent as aging progresses, significantly increasing the socioeconomic burden. In past studies, there has been a growing awareness of the harmful effects of heavy metals on bone, with cadmium being a significant exposure factor. The purpose of this study was to look into the association between adult bone mineral density(BMD) and blood cadmium levels.MethodsBased on information from the 2013–2014, 2017–2018 NHANES, weighted multiple regression, generalized weighted modeling, and smoothed curve fitting were utilized to investigate the association between blood cadmium and femur BMD. Furthermore, subgroup analyses were conducted to investigate any differences in the associations between age, sex, race, chronic kidney disease, and diabetes.ResultsIn 2,146 participants, blood cadmium levels and total femur [-0.02 (-0.03, -0.01), 0.0027], femoral neck [-0.01 (-0.02, -0.00), 0.0240], femoral trochanter [-0.01 (-0.02, -0.00), 0.0042], and intertrochanteric femoral trochanter [-0.02 (-0.03, -0.00), 0.0101] BMD were negatively correlated. Subgroup analyses showed that this association was more pronounced in women, non-Hispanic white people and other Hispanics, and those with chronic kidney disease and diabetes. Our results pointed to a negative relationship between femoral BMD and blood cadmium. This negative association varied by age, sex, race, diabetes, and chronic kidney disease. In particular, bone mineral density was more significantly negatively affected by blood cadmium levels in groups with diabetes and chronic kidney disease.ConclusionOur findings demonstrated a significant negative association between blood cadmium levels and bone mineral density in a population of U.S. adults.
Differentiated pattern of complement system activation between MOG-IgG-associated disease and AQP4-IgG-positive neuromyelitis optica spectrum disorder
Authors: Cho Eun Bin , Min Ju-Hong , Waters Patrick , Jeon Miyoung , Ju Eun-Seon , Kim Ho Jin , Kim Su-Hyun , Shin Ha Young , Kang Sa-Yoon , Lim Young-Min , Oh Sun-Young , Lee Hye Lim , Sohn Eunhee , Lee Sang-Soo , Oh Jeeyoung , Kim Sunyoung , Huh So-Young , Cho Joong-Yang , Seok Jin Myoung , Kim Byung-Jo , Kim Byoung Joon 
Published: March 2024

BackgroundMyelin oligodendrocyte glycoprotein antibody (MOG) immunoglobulin G (IgG)-associated disease (MOGAD) has clinical and pathophysiological features that are similar to but distinct from those of aquaporin-4 antibody (AQP4-IgG)-positive neuromyelitis optica spectrum disorders (AQP4-NMOSD). MOG-IgG and AQP4-IgG, mostly of the IgG1 subtype, can both activate the complement system. Therefore, we investigated whether the levels of serum complement components, regulators, and activation products differ between MOGAD and AQP4-NMOSD, and if complement analytes can be utilized to differentiate between these diseases.MethodsThe sera of patients with MOGAD (from during an attack and remission; N=19 and N=9, respectively) and AQP4-NMOSD (N=35 and N=17), and healthy controls (N=38) were analyzed for C1q-binding circulating immune complex (CIC-C1q), C1 inhibitor (C1-INH), factor H (FH), C3, iC3b, and soluble terminal complement complex (sC5b-9).ResultsIn attack samples, the levels of C1-INH, FH, and iC3b were higher in the MOGAD group than in the NMOSD group (all, p&lt;0.001), while the level of sC5b-9 was increased only in the NMOSD group. In MOGAD, there were no differences in the concentrations of complement analytes based on disease status. However, within AQP4-NMOSD, remission samples indicated a higher C1-INH level than attack samples (p=0.003). Notably, AQP4-NMOSD patients on medications during attack showed lower levels of iC3b (p&lt;0.001) and higher levels of C3 (p=0.008), C1-INH (p=0.004), and sC5b-9 (p&lt;0.001) compared to those not on medication. Among patients not on medication at the time of attack sampling, serum MOG-IgG cell-based assay (CBA) score had a positive correlation with iC3b and C1-INH levels (rho=0.764 and p=0.010, and rho=0.629 and p=0.049, respectively), and AQP4-IgG CBA score had a positive correlation with C1-INH level (rho=0.836, p=0.003).ConclusionsThis study indicates a higher prominence of complement pathway activation and subsequent C3 degradation in MOGAD compared to AQP4-NMOSD. On the other hand, the production of terminal complement complexes (TCC) was found to be more substantial in AQP4-NMOSD than in MOGAD. These findings suggest a strong regulation of the complement system, implying its potential involvement in the pathogenesis of MOGAD through mechanisms that extend beyond TCC formation.
Predictive factors of psychiatric syndrome in patients with systemic lupus erythematosus
Authors: Geng Wenqi , Zhang Shangzhu , Cao Jinya , Hong Xia , Duan Yanping , Jiang Yinan , Wei Jing 
Published: March 2024

IntroductionEarly detection of neuropsychiatric systemic lupus erythematosus (NPSLE) remains a challenge in clinical settings. Previous studies have found different autoantibodies as markers for NPSLE. This study aimed to describe the distribution of psychiatric syndromes in a group of patients with systemic lupus erythematosus (SLE) and to investigate the association between psychiatric syndromes and specific autoantibodies.MethodsThis retrospective study was conducted at a single medical center in China. We reviewed medical records of hospitalized patients with SLE who were consulted by psychiatrists due to potential mental disorders. Results of serum autoantibodies and general laboratory tests were collected. The correlation between clinical variables was examined. Binary logistic regression analyses were used to determine factors related to NPSLE and different psychiatric diagnoses.ResultsAmong the 171 psychiatric manifestations in 160 patients, 141 (82.4%) were attributed to SLE. Acute confusional state (ACS) had the highest prevalence (57.4%). Anti-cardiolipin (ACL) antibody (X2 = 142.261, p &lt; 0.001) and anti-β2 glycoprotein I (-β2GP1) antibody (X2 = 139.818, p &lt; 0.001) varied significantly between groups, with the highest positive rate found in patients with mood disorders (27.3% and 18.2%). SLE disease activity index – 2000 (SLEDAI-2K) score excluding item ACS and item psychosis was a predictor of NPSLE (OR 1.172 [95% CI 1.105 - 1.243]).ConclusionsDisease activity reflected by SLEDAI-2K score is a predictor for NPSLE. Antiphospholipid antibodies are associated with mood disorders in SLE. Further separate investigation of neuropsychiatric disorders is needed in order to better comprehend NPSLE’s pathological mechanism.
Clinical evidence of hyperbaric oxygen therapy for Alzheimer’s disease: a systematic review and meta-analysis of randomized controlled trials
Authors: Lin Guangyao , Zhao Li , Lin Jingyu , Li Xuanling , Xu Lianwei 
Published: March 2024

ObjectiveTo evaluate the potential benefits of hyperbaric oxygen intervention on people with Alzheimer’s disease (AD) based on the existing randomized controlled trials (RCTs).MethodsA systematic search was conducted in nine databases until November 17, 2023, for RCTs assessing the effect of hyperbaric oxygen intervention for AD. The primary outcomes included Mini-Mental State Examination (MMSE), Alzheimer’s Disease Assessment Scale-Cognitive (ADAS-Cog), activities of daily living (ADL), and adverse events. All results were shown in forest plots, and sensitivity analysis was adopted to further verify the robustness of the pooled results.ResultsA total of 11 RCTs recruiting 847 participants were included in this meta-analysis. Based on the pooled evidence, hyperbaric oxygen could remarkably ameliorate MMSE [MD = 3.08, 95%CI (2.56, 3.61), p &lt; 0.00001], ADAS-Cog [MD = −4.53, 95%CI (−5.05, −4.00), p &lt; 0.00001], ADL [MD = 10.12, 95%CI (4.46, 15.79), p = 0.0005], MDA levels [SMD = −2.83, 95%CI (−5.27, −0.38), p = 0.02], SOD levels [SMD = 2.12, 95%CI (1.10, 3.15), p &lt; 0.0001], IL-1-β levels [SMD = −1.00, 95%CI (−1.48, −0.53), p &lt; 0.0001], and TGF-β1 levels [MD = 4.87, 95%CI (3.98, 5.76), p &lt; 0.00001] without adverse events [OR = 1.17, 95%CI (0.68, 2.03), p = 0.58] for people with AD. The pooled results were robust after checking by sensitivity analysis.ConclusionThese evidences suggest that hyperbaric oxygen is an effective and safe intervention for the treatment of AD. Further studies with more rigorous design will help to fully evaluate the clinical value of hyperbaric oxygen on cognition function in people with AD.Systematic review registrationhttps://www.crd.york.ac.uk, identifier CRD42023483726.
Association between serum creatinine and 30 days all-cause mortality in critically ill patients with non-traumatic subarachnoid hemorrhage: analysis of the MIMIC-IV database
Authors: Zhong Yuan , Sun Hao , Jing Wenjuan , Liao Lixian , Huang Jiayi , Ma Junqiang , Chen Weiqiang 
Published: March 2024

BackgroundSerum creatinine is a prognostic marker for various conditions, but its significance of spontaneous subarachnoid hemorrhage is still poorly understood. This study aims to elucidate the correlation between admission serum creatinine (sCr) levels and all-cause mortality within 30 days among individuals affected by non-traumatic subarachnoid hemorrhage (SAH).MethodsThis cohort study included 672 non-traumatic SAH adults. It utilized data from the MIMIC-IV database from 2008 to 2019. The patients’ first-time serum creatinine was recorded. Subsequently, an examination of the 30-day all-cause mortality was conducted. Employing a multiple logistic regression model, a nomogram was constructed, while the association between sCr and 30-day all-cause mortality was evaluated using Kaplan–Meier survival curves. The calibration curve was employed to assess the model’s performance, while subgroup analysis was employed to examine the impact of additional complications and medication therapy on outcomes.ResultsA total of 672 patients diagnosed with non-traumatic subarachnoid hemorrhage were included in the study. The mortality rate within this timeframe was found to be 24.7%. Multiple logistic regression analysis revealed that sCr served as an independent prognostic indicator for all-cause mortality within 30 days of admission for SAH patients [OR: 2(1.18–3.41); p = 0.01]. A comprehensive model was constructed, incorporating age, sCr, white blood cell count (WBC), glucose, anion gap, and partial thromboplastin time (PTT), resulting in a prediction model with an AUC value of 0.806 (95% CI: 0.768, 0.843), while the AUC for the test set is 0.821 (95% CI: 0.777–0.865).ConclusionCreatinine emerges as a significant biomarker, closely associated with heightened in-hospital mortality in individuals suffering from SAH.
Development of an artificial intelligence based occupational noise induced hearing loss early warning system for mine workers
Authors: Madahana Milka C. I. , Ekoru John E. D. , Sebothoma Ben , Khoza-Shangase Katijah 
Published: March 2024

IntroductionOccupational Noise Induced Hearing Loss (ONIHL) is one of the most prevalent conditions among mine workers globally. This reality is due to mine workers being exposed to noise produced by heavy machinery, rock drilling, blasting, and so on. This condition can be compounded by the fact that mine workers often work in confined workspaces for extended periods of time, where little to no attenuation of noise occurs. The objective of this research work is to present a preliminary study of the development of a hearing loss, early monitoring system for mine workers.MethodologyThe system consists of a smart watch and smart hearing muff equipped with sound sensors which collect noise intensity levels and the frequency of exposure. The collected information is transferred to a database where machine learning algorithms namely the logistic regression, support vector machines, decision tree and Random Forest Classifier are used to classify and cluster it into levels of priority. Feedback is then sent from the database to a mine worker smart watch based on priority level. In cases where the priority level is extreme, indicating high levels of noise, the smart watch vibrates to alert the miner. The developed system was tested in a mock mine environment consisting of a 67 metres tunnel located in the basement of a building whose roof top represents the “surface” of a mine. The mock-mine shape, size of the tunnel, steel-support infrastructure, and ventilation system are analogous to deep hard-rock mine. The wireless channel propagation of the mock-mine is statistically characterized in 2.4–2.5 GHz frequency band. Actual underground mine material was used to build the mock mine to ensure it mimics a real mine as close as possible. The system was tested by 50 participants both male and female ranging from ages of 18 to 60 years.Results and discussionPreliminary results of the system show decision tree had the highest accuracy compared to the other algorithms used. It has an average testing accuracy of 91.25% and average training accuracy of 99.79%. The system also showed a good response level in terms of detection of noise input levels of exposure, transmission of the information to the data base and communication of recommendations to the miner. The developed system is still undergoing further refinements and testing prior to being tested in an actual mine.