bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sex differences in immunotherapy outcomes and tumor-infiltrating immune cell profiles in patients with advanced renal cell carcinoma
Authors: Ishihara Hiroki , Fukuda Hironori , Mizoguchi Yukihiro , Yamashita Makiko , Aoki Kazunori , Ishiyama Ryo , Ikeda Takashi , Nemoto Yuki , Shimmura Hiroaki , Hashimoto Yasunobu , Yoshida Kazuhiko , Hirai Toshihito , Iizuka Junpei , Tokita Daisuke , Kondo Tsunenori , Nagashima Yoji , Takagi Toshio 
Published: April 2024

Abstract

Sex differences in the outcomes of advanced renal cell carcinoma (RCC) treated with immune checkpoint inhibitors (ICIs) and the profiles of tumor-infiltrating immune cells (TIICs) remain unclear. We retrospectively evaluated data from 563 patients with RCC receiving systemic therapy, including first-line dual ICI combinations (i.e., immunotherapy [IO]-IO), combinations of ICIs with tyrosine kinase inhibitors (TKIs) (i.e., IO-TKI), TKI monotherapy, and subsequent nivolumab monotherapy. Survival and tumor response were compared between the sexes in each treatment group, and TIIC profiles were compared using 116 RCC tumor samples analyzed by flow cytometry. Progression-free survival (PFS) was shorter in female than in male patients in the IO-IO (p = 0.0227) and nivolumab monotherapy (p = 0.0478) groups. Furthermore, sex remained an independent factor for shorter PFS after adjusting for covariates in the IO-IO (p = 0.0340) and nivolumab monotherapy (p = 0.0322) groups. In contrast, PFS was not significantly different between sexes in the IO-TKI or TKI monotherapy groups (p > 0.05). Overall survival and objective response rates were not significantly different between the sexes in any of the treatment groups (p > 0.05). Some TIIC populations, including that of CD8 + T cells (p = 0.0096), decreased to a greater extent in female than in male patients in the advanced-stage population. The effectiveness of ICIs on PFS was lower in female patients than in male patients, potentially because of the different profiles of the immune microenvironment, particularly the decreased number of CD8 + T cells in females.
Impact Analysis of Hybrid Renewable Energy Penetration on Radial Distribution Feeder of 32-Bus System
Authors: Fayyaz Kaynat , Raza Safdar , Hayat Ahmad 
Published: April 2024

Abstract

The issue of rising energy demand can be mitigated through the use of distributed generating without requiring an expansion of the transmission and distribution network. The transformation of distributed networks from passive to active has occurred because of increased penetration of distributed generation on low voltage feeders. This penetration also compromises the power quality of the system and gives rise to a number of issues, including voltage fluctuations and current swings that exceed the nominal value. This paper utilizes the Power World Simulator (PWS) to investigate the effects of hybrid renewable energy which is combination of wind and solar, on medium voltage feeder voltages through a case study of a 32-bus radial feeder network. Genetic Algorithm were used for finding of optimum value of distribution generation. Additionally, it is recommended to consider the maximum generation penetration without exceeding the nominal voltage restrictions of the feeder. As a result, the voltage drops and line losses were reduced.
Antibacterial and seed germination activities of biosynthesized zinc oxide nanoparticles using aqueous leaf and fruit extract of Annona reticulata
Authors: Shobana C. , Malavika J. P. , Nithya V. D. , Vishwanathan M. , Srinit P. , Ganeshbabu M. , Puneeth N. Prasanna Naga , Sudhakar C , Selvankumar T. 
Published: April 2024

Abstract
In the present work, the zinc oxide nanoparticles were synthesized using an environmentally friendly green synthesis method utilizing Annona reticulata leaf and fruit extracts and compared with the ZnO prepared by the chemical route method. The Rietveld refinement X-ray diffraction (XRD) pattern revealed the formation of wurtzite-structured ZnO. The presence of abundant hydroxyl functional groups with Zn-O stretching vibrations was corroborated using Fourier Transform Infrared (FTIR) spectroscopic analysis. The particle size distribution and the morphological analysis were inferred through the Field emission scanning electron microscopic (FESEM) images. The antibacterial potential of the prepared ZnO NPs was evaluated against pathogenic strains of Staphylococcus aureus, Enterococcus faecalis, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Escherichia coli. Based on the zone of inhibition, the fruit-derived ZnO NPs showed higher antibacterial activity, followed by leaf-derived and chemically synthesized nanoparticles. Notably, fruit-derived ZnO NPs exhibited an almost equal zone of inhibition of 21.1 mm at 100 µg and a greater zone of inhibition of 16.9 mm at 50 µg against Klebsiella pneumoniae compared to antibiotic streptomycin. Finally, the germination of Vigna radiata seeds under the influence of ZnO NPs demonstrated that the nanoparticles favoured seed germination at a lower concentration of 2.5 mg. The highest seed germination was observed in green synthesized ZnO NPs (26 cm), with both leaf and fruit-derived nanoparticles exhibiting almost similar impacts on seed germination. The findings indicate that Annona reticulata-derived ZnO NPs could be utilized as potential antibacterial agents.
Proteomics analysis revealed the mechanism of differential egg productive in geese
Authors: Yang Lei , Jia Changze , Li Yanzhong , Zhang Yafei , Ge Kai , She Deyong , Fan Shuhao 
Published: April 2024

Abstract

Background
The Western Anhui white goose is a highly esteemed breed in our country, renowned for its superior meat quality and exceptional egg-laying performance. As the primary reproductive organ in poultry, the ovary significantly influences the sexual maturation and reproductive capacity of female animals. Understanding the molecular basis underlying nesting behavior in geese relies on understanding the variations in ovarian proteins during different nesting periods. To investigate the effect of proteins on nesting behavior and fecundity, we selected ovarian tissues from three high-and three low-fertility Wanxi white geese.
Result
By employing a tandem mass-tag-based quantitative proteomics method, we successfully identified 4611 proteins, of which 111 exhibited significant differences. KEGG enrichment analysis revealed that these differentially expressed proteins were primarily associated with glycolysis and folate biosynthesis pathways. Furthermore, our protein-protein interaction network analysis demonstrated that the interacting proteins predominantly participated in ribosome function as well as amino acid and carbohydrate metabolism.
Conclusions
The findings of this study establish a foundation for elucidating the molecular mechanism underlying variations in ovarian protein levels among Wanxi white geese with different fecundity.
Fabrication of (PVA-ZnO) nanocomposites and study of morphological, optical and electrical properties
Authors: Mohaimeed Ameen Alwan , Rasheed Maher Hassan , S Murtadha K. 
Published: April 2024

Abstract

This paper's goal is to prepare PVA with ratios of 0.2, 0.4 and 0.6 wt% by casting method and with a thickness of 270 ± 5 micrometers. The morphological characteristics were examined (FE-SEM and FTIR) and the results showed that the composites have a homogeneous and granular structure and that ZnO is well distributed within the polymer, The reason for the increased movement of charges is the action of a grid of nanomaterials inserted into the polymer. FTIR analyses the absorption peak seen at 3321.33 cm− 1 is due to O-H bond that indicates the polymer and serves as its identity. The absorbance of the prepared composites showed an increase with increasing concentration of nanomaterials. In addition, the energy gap decreased with increasing concentration(2.8 to 2.5 eV) of nanomaterials, and all optical parameters (α, n, k°, Ɛr, Ɛi) increased with increasing concentration of nanomaterials. For all samples, it is found that the dielectric constant decreases as frequency increases, it also increases with increasing concentration of nanomaterials within the polymer. The decrease in the effect of charge polarization is the main factor in the dielectric loss of the PVA-ZnO nanocomposite, the same time, increasing the concentration of nanomaterials leads to an increase in the value the dielectric loss. The increase in the frequency of the electric field and the increase in the concentration of nanomaterials increases the electrical conductivity. This makes these films useful for electronic applications and light filters, and they can also be used as ultraviolet detectors and humidity sensors.
Diversity and Distribution of Seaweeds in the Androth Island of Lakshadweep Archipelago
Authors: AI Najva , Govindan Rekha 
Published: April 2024

Abstract

The coral lagoons of Lakshadweep have been widely reported to have luxuriant growth of seaweeds. In these coral reef ecosystems, calcareous algae form the important group in seaweeds, as they are essential in the formation of coral reefs. Though several surveys of seaweed growth have been carried out from time to time in different regions of the mainland, Lakshadweep and Andaman-Nicobar Islands, studies are lacking from the Androth island, one of the Laccadivian archipelago islands to identify seaweed growing areas in Androth. Also, there is no significant work to assess the standing crop of seaweeds in Androth. Therefore, this study was attempted to map the distribution and diversity of seaweed species in the Andrott island of Lakshadweep. In agreement with studies on the coastal distribution of seaweed fauna and flora, our study also identified extensive growth of seaweeds species like Halimeda, Chaetomorpha , Boodlea, Composita, Chaetomorpha, Enteromorpha, Padina, Sargassum wightil, Acanthophora specifera etc along the coral coast of Androth island belonging to the Lakshadweep Archipelago.
Comparison of three insect larvae biodegrading polyethylene and role of the intestinal bacterial strains in polyethylene degradation by Galleria mellonella larvae
Authors: Gu Wenxuan , Xie Chenjie , Song Ping , Wang Qinying , NanGong Ziyan 
Published: April 2024

Abstract

Polyethylene (PE) has been described as the most abundant plastic worldwide, such as mulching films and plastic bags. A few insects have been identified to ingest and metabolize polyethylene. In this study, we contrasted the degradation ability of three insect larvae (Galleria mellonella, Tenebrio molitor and Zophobas morio) biodegrading polyethylene. The results demonstrated that G. mellonella has the best digestion ability on polyethylene. Eating and digestion of plastic products for a long time will inevitably cause negative effects on insects. The additional nutrients can improve the health of the PE-degrading insects, thus extending the digestion time of the plastic. Microbial degradation of polyethylene (PE) products has attracted much attention. Here, two bacterial isolates, Fictibacillus phosphorivorans A-2 and Pseudomonas sp. A-3 from the gut of PE-feeding G. mellonella, was suggested to utilize PE. Two bacterial isolates removed approximately 3.57 ± 0.30% and 2.00 ± 0.16% of PE films after 40 days at 30 ◦C, respectively. We demonstrated the ability for PE degradation of F. phosphorivorans A-2 at greater rates than Pseudomonas sp. A-3. The results suggest that supplementing the co-diet affected the physiological properties of the PE-degrading insect and plastic biodegradation. This study enriched microbial resources for PE degradation and provided promising evidence for the biodegradation of PE in the environment.
Drained cavity expansion analysis with a unified hardening (UH) model for clays and sands
Authors: Li Jia-Bin , Li Ming-Guang , Chen Jin-Jian , Candidate Xiao 
Published: April 2024

Abstract

This study presents a novel semi-analytical solution for the drained expansion of cylindrical and spherical cavities with a unified hardening model for both clays and sands (CSUH). The three-dimensional strength of soils is considered using the stress transformation method. Large-strain analyses are incorporated into the developed cavity expansion solution to obtain the entire stress-strain histories of soils in the plastic regions. By formulating the problem as an initial value problem in the Lagrangian scheme using an auxiliary independent variable, the present study solves the problem numerically. A thorough parameter analysis is conducted for both cylindrical-spherical and clay-sand scenarios, and the results are compared with other existing solutions to demonstrate the distinctive attributes of the present solution. It is found that the present solution can effectively capture the evolution processes of both strength and overconsolidation characteristics of soils, as well as the contracting and dilating behaviors of soils. Three key advantages of the present solution are its sufficient accuracy, less and easily determined parameters, and broad applicability in both clays and sands, resulting in extensive application in engineering, including tunneling, pile foundation construction, and cone penetration tests in clay-sand scenarios under drained conditions.
Performance Analysis of Suggestion Mining for Mobile Apps
Authors: Mali Makarand 
Published: April 2024

Abstract

Extracting actionable improvement suggestions from user reviews remains a critical challenge in mobile app development. We propose two novel Natural Language Processing (NLP) techniques specifically designed to bridge this gap. The first technique leverages a fine-tuned Bidirectional Encoder Representations from Transformers (BERT) model, while the second employs a lightweight DistilBERT model. Both are trained on domain-specific action verbs and phrases indicative of desired app changes within the mobile app domain. We evaluate the effectiveness of these techniques through a comprehensive case study analyzing a substantial dataset of 8,061 Mobile app reviews. Our findings demonstrate the efficacy of these techniques in capturing valuable user insights that can inform development efforts and ultimately enhance mobile app quality. This, in turn, has the potential to translate into a more user-centric experience, potentially leading to increased user satisfaction and reduced app churn. Further research could explore advanced analysis of extracted suggestions to prioritize user concerns and inform targeted development initiatives.
Numerical simulation of heat transfer characteristics of composite structure jet microchannel based on Eulerian method
Authors: Juhui Chen , Wang Junqiao , Li Dan , Lu Wensheng , Meng Fanqi 
Published: April 2024

Abstract

In this paper, in order to investigate the heat transfer characteristics of three-dimensional nanofluid jet microchannel (NJMC), the two-fluid model based on Euler's method coupled with the turbulence model is used to numerically simulate the Al2O3-desionized water jet impingement cooling process, and the results of the study show that the inlet flow rate of the nanofluid can strengthen the degree of its jet focusing and enhance the performance of heat transfer. In this paper, it is also found that the hemispherical micro-rib and side-flow orifices in the nanofluid array jet microchannel (NAJMC) can effectively strengthen the longitudinal vortex and slow down the velocity drift, and the nested micro-rib can effectively reduce the irreversible loss in the flow of nanofluid, and all three of them can make the heat transfer performance of the NAJMC go up. Therefore, in this paper, a nanofluid composite jet microchannel (NCJMC) is designed and numerically simulated, and the entropy production theory is used to analyze and evaluate the heat transfer performance of MCJMC, and it is found that the heat transfer performance of NCJMC is significantly improved compared with that of NAJMC. When the inlet flow rate is the same, its Nu and PEC are increased by 21.3% and 60.0%, respectively, compared with MAJMC, and the total entropy production is reduced by 38.0%.
(Re)understanding the relationship between Fiscal Decentralization and property tax revenue: Insights from developing and developed countries.
Authors: AFFROUMOU TIEMELE ARISTIDE 
Published: April 2024

Abstract

Several countries over the world have experimented with fiscal decentralization policies in order to enhance the autonomy of their respective local governments. This could improve the level of tax revenue and consequently improve public service delivery. In this vein, the present study revisits the impact of fiscal decentralization (FD) on property tax revenue collection in a sample of developed and developing countries over the period 2005–2019. Using OLS fixed effects estimations, we find a strong positive effect of fiscal decentralization on property tax revenues, and a greater level of democracy also contributes to reinforcing the positive relationship between fiscal decentralization and property tax revenue. However, we find that a higher level of control of corruption can cancel the positive effect of fiscal decentralization on property tax revenue. In addition, using quantile regression, the paper shows that countries below the median of property tax revenue are less susceptible to benefit from fiscal decentralization compared to countries above the median levels of property tax revenue. Finally, the study suggests that improving fiscal decentralization can promote property tax revenue collection, which is relevant for both developed and developing countries. The success of policies surrounding the relationship between property tax revenue and fiscal decentralization is contingent upon implementing attendant policies tailored differently across countries with varying initial levels of property tax revenue. Specifically, these policies are unlikely to be effective unless they consider each country’s initial levels of property tax revenue.
JEL classification : H71, H72, H77
Population Status of Boswelia papyrifera dominated woodland in North West Ethiopia
Authors: Nigus Adane Mulat , Wasie Abeje Eshete 
Published: April 2024

Abstract

The three main genera that produce gum and resin in Ethiopia's lowland forests are Acacia, Boswellia, and Commiphora. Boswellia papyrifera is mainly found in the degraded drylands that are dispersed across many regions of Ethiopia. The purpose of the study was to evaluate the resource status of the northern Ethiopian area of Burie Zuria, which is home to woods dominated by Boswellia papyrifera. Determining the district's Boswellia papyrifera-dominated woodland's regeneration status and quantifying the population structure of the existing species are among the objectives of the study. From 25mx25m, 5mx5m and 1mx1m size plots, tree, sapling and seedling were collected respectively and the collected data was analyzed through a descriptive statistics. According to the findings, the target species, Boswellia papyrifera, had a bell-shaped population structure and a fair regeneration status. Its population structure dominated woods in both the DBH and height class distribution, exhibiting an inverted "J" form. Some species such as Boswelia papyrifera (51.2%), Lannea schimperi (18.06%), and Erythroxylum fischeri (17.6%) had large important value index. The results conclude that the regeneration status and population structures of majority species indicate there is disturbances effect within the area. The finding showed that the population structure of large IVI species was bell-shaped so to sustain such species regular monitoring and conservation activities should be implemented and the finding revealed that the regeneration status of majority species within woodland were fair means there is an anthropogenic disturbance so to minimize such disturbances effect participatory forest management activities should be implement.
The effect and newly developed mechanisms of digital transformation on green innovation: evidence from listed firms in China
Authors: Zhu Lei , Wang Chunyan , Wang Xiaohan , Li Tong 
Published: April 2024

Abstract

This study explores the impact of digital transformation on green innovation and reveals two newly developed mechanisms including technical imprint of senior executives and media attention. The results show that digital transformation of enterprises promote green innovation significantly. In addition, the enabling role of digital transformation on green innovation is reinforced by executives who have a high technological footprint and by firms' significant media attention. These findings not only provide novel insights to drive enterprise green innovation in the digital economy age, but also offer useful measures to policy makers and firms to implement sustainable development in developing countries.
A detail investigation of CT-DNA/BSA binding of new palladium complex by experimental techniques along with molecular docking and molecular dynamic simulations
Authors: Tabatabai Ashraf Sadat Dorafshan , Dehghanian Effat , Mansouri-Torshizi Hassan 
Published: April 2024

Abstract
A novel mononuclear palladium complex, [Pd(dach)(SSA)], where dach and SSA are diaminocyclohexane and sulfosalicylic acid ligands, respectively, has been synthesized and identified utilizing analytical and spectral methods. DFT calculations, namely geometry optimization, MEP, HOMO-LUMO and NBO analysis, have been conducted at B3LYP level by aug-ccpVTZ-PP and 6-311G(d,p) basis sets. By employing MTT assay, the cytotoxicity activity of the aforesaid compound was examined on K562 cell line, which revealed a proper activity compared to cisplatin. To ascertain the lipophilicity of the newly made compound, the partition coefficient measurement was accomplished, which follows the order of cisplatin < Pd(II) complex. Next, investigation of binding properties of the studied compound with DNA of calf thymus and BSA were done by spectroscopic (CD, fluorescence emission and electronic adsorption) and non-spectroscopic (viscosity measurements, DNA gel electrophoresis, molecular docking and molecular dynamics simulation) methods. Data obtained from UV-Vis studies indicate non–intercalative mutual action. Fluorescence quenching mechanism of the two biomolecules by metal complex is static and the calculated thermodynamic parameters suggests the hydrogen bonding to the DNA and BSA. Further, docking simulation indicated that the studied compound fits into the groove of DNA and the BSA site I. The stability of metal compound-DNA/-BSA in the presence of H2O solvent and over the time were validated via molecular dynamics simulation.
TSPT ReID: Triple Streams with Pos-insertion Transformer for Person Re-identification
Authors: Li Xujun , Rao Liming , Zhang Tengze , Chang Jia , Duan Zhicheng 
Published: April 2024

Abstract

In the process of person re-identification (ReID), the disparity of various datasets caused by different cameras and viewing distances poses challenges. Additionally, the inherent limitation of convolutional neural networks (CNNs) in capturing long-range dependencies exacerbates these challenges. To address these issues, this paper proposes the Triple Streams with Pos-insertion Transformer ReID (TSPT ReID) based on the Transformer architecture. The key design of TSPT ReID, the Triple Streams Transformer Encoder (TST Encoder), establishes multi-head attention layers on three different scales to enhance the correlation between various scales. To enhance the recognizability and robustness of valid pedestrian edges, the Shift Pos-insertion Module (SPI Module) is introduced by adding shift-based position coding in the attention layers without introducing additional parameters. The experimental results show the effectiveness of the model on multiple datasets, achieving 82.9% mAP and 91.4% Rank-1 accuracy on the DukeMTMC, and 83.5% mAP and 85.9% Rank-1 accuracy on CUKH03.