bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immunolocalization of hepatic metastases of human colonic cancer by chimeric anti‐TAG72 antibody in scid mice
Authors: Qi Yumin , Moyana Terence , Matte Gilbert , Wilkinson Alex , Bresalier Robert , Xiang Jim 
Published: February 2007

AbstractTAG72 is a well‐characterized, human tumor‐associated antigen present in >85% of human colonic cancers. In this study, we established an animal model of hepatic metastases of human colonic carcinoma. The high‐mucin variant cell line, designated HM7, was derived from the human colonic carcinoma cell line LS174T. Following intrasplenic injection, HM7 was able to induce much greater hepatic metastases in SCID mice compared to its parental cell line LS174T. Numerous hepatic metastases were evident 18 days subsequent to the intrasplenic injection of tumor cells. Using the chimeric anti‐TAG72 antibody ccM4, immunohistochemistry demonstrated strong expressions of the TAG72 antigen in these metastases. Our biodistribution and imaging data also showed that the radiolabelled ccM4 antibody was able to localize hepatic metastases in the SCID mice. Based upon these findings, w anticipate that the herein described SCID mouse model will prove most useful in studying hepatic metastases of human colonic carcinoma by using anti‐TAG72 therapeutic immunoreagents.
PSA‐detected prostate cancer: Contrasts with palpable disease
Authors: Matthews Gerald J. , Fracchia John A. 
Published: February 2007

AbstractThe clinical and pathologic characteristics of 100 consecutive men with clinically localized prostate cancer and staged by radical prostatectomy were reviewed. Men with impalpable prostate‐specific antigen (PSA) detected cancers (T1c) were contrasted against men with palpable disease (TB). Lesions were clinically staged as T1c in 53 men and TB in 47 men. Mean serum PSA for men with T1c cancers was 11.8 ± 0.7 ng/dL (normal: 0 > 4) and 14.1 ± 1.7 ng/dL for men with TB disease. Histologic evaluation revealed a mean Gleason's sum of 6.4 ± 0.2 (scale: 2 > 10) for T1c lesions and 6.6 ± 0.2 for men with TB cancers (P = NS). DNA content was diploid in 67% of T1c cancers and 62% of TB lesions (P = NS). An overall 43% clinical staging error was observed. Extraprostatic extension was demonstrated in 36% of T1c cancers and 51% TB lesions (P = NS). PSA‐detected cancers were indistinguishable from palpable lesions by all measures evaluated. Prostate cancers detected in asymptomatic men by an elevated PSA should be considered biologically significant lesions.
Hyperthermochemoradiotherapy is effective for small cell carcinoma of the esophagus
Authors: Mimori Koshi , Mori Masaki , Kuwano Hiroyuki , Sugimachi Keizo 
Published: February 2007

AbstractEsophageal small cell carcinoma is a highly aggressive disease, and no effective treatment has yet been reported. We present here two cases of esophageal small cell carcinoma preoperatively treated with a combination of hyperthermia, irradiation, and an intravenous infusion of cis‐diamminedichloroplatinum (CDDP). The first case concerned a 67‐year‐old Japanese woman. Hyperthermochemoradiotherapy (HCR) was performed before surgical treatment. A histopathologic study of the resected specimen showed no residual viable cancer cells either in the esophagus or in the dissected lymph node. The second case involved a 59‐year‐old Japanese man who received HCR therapy before surgical treatment. This patient survived for 33 months, the longest known period of survival for small cell carcinoma of the esophagus. These cases indicate that preoperative hyperthermochemoradiotherapy may be considered one promising adjuvant therapy alternative for this aggressive disease.
Malignant germ cell tumors of the ovary: A study of 20 cases
Authors: Piura Benjamin , Dgani Ram , Zalel Yaron , Nemet Dan , Yanai‐Inbar Ilana , Cohen Yoram , Glezerman Marek 
Published: February 2007

AbstractIn a study of 20 patients diagnosed with malignant ovarian germ cell tumors between 1961 and 1993, clinical and pathologic findings were evaluated. Of the 20 patients, seven (35%) had dysgerminoma, two (10%) endodermal sinus tumor, three (15%) malignant teratoma, one (5%) malignant struma ovarii, one (5%) primary ovarian carcinoid, two (10%) benign teratoma with malignant transformation, and four (20%) combination germ cell tumor. Twelve patients (60%) had stage IA, five (25%) stage IC, and three (15%) stage IIIC. Twelve patients (60%) underwent conservative surgery and eight (40%) had at least bilateral salpingo‐oophorectomy. At follow‐up, 18 patients (90%) were alive free of disease, one (5%) had died of disease, and one (5%) had died of intercurrent disease. The actuarial 5‐year survival rate was 93.3%. It is concluded that for young women who wish to preserve child‐bearing capacity, regardless of the stage of the tumor, fertility‐preserving surgery with complete surgical staging followed, if necessary by cisplatin‐based combination chemotherapy is an appropriate and definitive treatment in the absence of involvement of the contralateral ovary and uterus. For patients in whom child‐bearing capacity is not an issue, surgery should include total abdominal hysterectomy and bilateral salpingooophorectomy with complete staging, followed if necessary by chemotherapy.
Hyperthermic isolated regional perfusion with cisplatin in the local treatment of spontaneous canine osteosarcoma: Assessment of short‐term effects
Authors: Van Ginkel Robert J. , Hoekstra Harald J. , Meutstege Freek J. , Oosterhuis Jan W. , Uges Donald R. A. , Koops Heimen Schraffordt 
Published: February 2007

AbstractTo increase the effect of cisplatin on locoregional osteosarcoma, the shortterm effect of hyperthermic isolated regional perfusion (HIRP) with cisplatin (30 mg/L extremity volume) was studied in 28 dogs with spontaneous osteogenic sarcoma, using clinical, radiological, and histological parameters. Thirty days postoperatively, mortality was 14.3%. Total platinum levels at the start of perfusion were 28.2 ± 14.3 mg/L. A significant improvement (P< 0.001) in clinical score was observed in the overall group at 6 and 12 weeks after perfusion. The radiological parameter showed a stationary X‐ray 2 weeks after perfusion and an improved X‐ray 6 weeks after perfusion. Overall histological scores showed a moderate effect according to the Huvos classification. No additional therapeutic effect, according to the three parameters, could be demonstrated by increasing the perfusate temperature by 1°C. HIRP with cisplatin is feasible in the local treatment of spontaneous osteosarcoma in dogs with acceptable locoregional toxicity. However, the histological results were modest, with none of the dogs showing a complete response 6 weeks after perfusion. Therefore, the search for the ideal perfusion agent with substantial contribution to the limb‐sparing treatment in human osteosarcoma continues.
Tumor ploidy as a risk factor for disease recurrence and short survival in surgically‐treated dukes' B2 colon cancer patients
Authors: Nori Dattatreyudu , Merimsky Ofer , Samala Engracio , Saw Daisy , Cortes Engracio , Chen Ellen , Turner James W. 
Published: February 2007

AbstractThe risk factors for colon cancer recurrence following a curative intent surgery include the presence of metastatic disease, the tumor location and size, number of positive lymph nodes, the presence of adhesions, perforation, bowel obstruction, depth of invasion, histological grade, percentage of S‐phase content, and cell kinetic profile.The DNA content of colon cancers in 20 Dukes' B2 patients in follow‐up evaluation at our center, who relapsed, either locally or systemically following surgical treatment was measured by image analysis. The data were pair‐matched for age, sex, tumor site, and grade with 20 Dukes' B2 patients who had no evidence of disease.Aneuploidy occurred in 16 (80%) patients with recurrence, as compared with only in 8 (40%) in the control group. Aneuploidy was associated with significantly higher tumor recurrence rate (P = 0.024) and shorter overall survival (P 0.002).Our data may point out a possible indication for systemic adjuvant chemotherapy in Dukes' B2 colon cancer patients who have aneuploid tumors on image analysis. This warrants further investigation in a prospective controlled randomized study.
Early experience with videothoracoscopic hydrodissection pleurectomy in the treatment of malignant pleural effusion
Authors: Harvey James C. , Erdman Christopher B. , Beattie Edward J. 
Published: February 2007

AbstractParietal pleurectomy is our preferred procedure for management of malignant pleural effusion. However, the morbidity of a major thoracotomy has precluded all but highly selected patients from the conventional (open) procedure. Recently, we have been able to perform parietal pleurectomy by means of a video‐assisted, thoracoscopic technique. We have retrospectively analyzed the results of this procedure performed on 11 patients between March 1993 and February 1995. These patients ranged in age from 40 to 87 years of age, with a mean age of 61.5 years. Primary tumors were non‐small cell lung cancer (5), breast cancer (4), mesothelioma (1), and unknown (1). There was one operative mortality (9.1%). All were relieved of symptoms of pleural effusion. Median survival was 128 days. Early experience indicates we are accomplishing an operation equivalent to that formerly performed by “open” technique. If continued results are similar to our initial experience, we will be able to offer this superior palliation of malignant pleural effusion to a wider range of patients.
Von recklinghausen's disease associated with a primary malignant schwannoma of the breast
Authors: Malas Simon , Krawitz Hedley E. , Sur Ranjan K. , Uijs Ronald R. , Nayler Simon J. , Victor Levin C. 
Published: February 2007

AbstractA case of a primary malignant schwannoma of the breast is reported. This case and the review of the literature illustrate the problems of diagnosing and treating this rare malignancy.
Simultaneous occurrence of medullary carcinoma and papillary carcinoma and papillary carcinoma of the thyroid
Authors: Kobayashi Kaoru , Teramoto Seiichi , Maeta Hiroyuki , Ishiguro Shingo , Mori Tohru , Horie Yasushi 
Published: February 2007

AbstractWe report a case of simultaneous occurrence of medullary carcinoma and papillary carcinoma of the thyroid in the same thyroid gland. Immunoreactivity of calcitonin, carcinoembryonic antigen, neuron specific enolase and thyroglobulin made a sharp distinction between both neoplasms of the thyroid. It appears reasonable to consider that simultaneous occurrence of medullary carcinoma and papillary carcinoma of the thyroid in this case does not have embryological or genetical significance. © 1995 Wiley‐Liss, Inc.
Partial cystectomy for invasive bladder cancer
Authors: Dandekar Niteen P. , Tongaonkar Hemant B. , Dalal Amish V. , Kulkarni Jagdeesh N. , Kamat Murali R. 
Published: February 2007

AbstractThirty two patients—23 males and 9 females with a mean age of 52.5 years—underwent planned partial cystectomy for histologically proved muscle invasive bladder cancer. Twenty patients had transitional cell carcinoma and 12 had adenocarcinoma of the bladder. One patient had well‐differentiated, 18 had moderately differentiated, and 13 had poorly differentiated tumours. The tumour size was <2 cm in 7 patients, 2–4 cm in 19 patients, and >4 cm in 6 patients. Patients with single primary muscle invasive tumours situated in the upper half of the bladder were considered eligible for partial cystectomy. The presence of multicentric urothelial disease, of dysplasia, or carcinoma‐in‐situ in bladder mucosa away from the tumour on multiple random punch biopsies was considered contraindications to partial cystectomy. All patients underwent partial cystectomy with bilateral pelvic lymphadenectomy. The tumour‐free margins of resection were confirmed by intraoperative frozen section examination. The bladder was closed primarily in all patients, although three patients required re‐implantation of the ureter. No patient received adjuvant radiation or chemotherapy. Five patients had pathological stage Bl (T2), 18 had B2 (T3A), and 9 had C (T3B) disease. No patient had metastatic pelvic lymph nodes. There was one postoperative death due to unrelated medical cause. Five patients had minor complications that resolved with conservative measures. All patients had adequate bladder capacity of >250 cc at 6 months after surgery, and none had symptoms attributable to reduced bladder capacity. The overall actuarial survival was 80.1% at 5 years. The 5‐year survival for patients with stage T2 tumours was 100%, for stage T3A 88.5%, and for stage T3B 45.7% (P = 0.028). The 5‐year survival for patients with tumour size < 2 cm was 100% compared to 83. 1% for 2‐4 cm and 50% for size more than 4 cm (P = 0.078). There was no significant difference in survival for patients with transitional cell carcinoma (83.8%) and adenocarcinoma (74.1%) (P = 0.511). Patients with well‐differentiated tumours had a 5‐year survival of 100% as compared to 94.4% for moderately and 53.5% for poorly differentiated tumours (P < 0.001). Fourteen patients relapsed—12 in the bladder and 2 in the lungs without relapse in the bladder. Of the 12 patients who relapsed in the bladder, 5 had noninvasive (stage Ta/Tl) relapses and were salvaged with transurethral resection of the tumours. Seven patients had invasive tumours at relapse that were related to tumour stage and grade. Four of these could be salvaged with radical total cystectomy, where as the remaining three and the two patients with distant relapses died due to disseminated disease. © 1995 Wiley‐Liss, Inc.
Small hepatocellular carcinoma of single nodular type: A specific reference to its surrounding cancerous area undetected radiologically and macroscopically
Authors: Maeda Takashi , Takenaka Kenji , Adachi Eisuke , Matsumata Takashi , Shirabe Ken , Honda Hiroshi , Sucimachi Keizo , Tsuneyoshi Masazumi 
Published: February 2007

AbstractA total of 128 surgically resected small hepatocellular carcinomas, measuring less than or equal to 3 cm in diameter, were studied by both macroscopic and histologic examinations. In 95 single nodular‐type tumors of the 128 lesions, eight tumors were associated with the cancerous areas of well differentiated hepatocellular carcinoma around the nodule. These surrounding cancerous areas went undetected by both the preoperative radiological examinations and the gross findings of resected specimens. Based on the immunohistochemical findings, the labeling index, both of the proliferating cell nuclear antigen (PCNA) and of the Ki‐67 in the surrounding cancerous areas, were lower than that of the main nodules but higher than in the nontumorous liver parenchyma in seven of eight cases. These results suggest that the main nodule was generated from the surrounding cancerous area, supporting the hypothesis of a stepwise progression of HCC. Even if the tumor seems to be a small and single nodular type, it is recommended that its surrounding areas should be closely examined and the surgical cutting margin should be made more than 1.0 cm away from the main nodule at hepatic resection. © 1995 Wiley‐Liss, Inc.
Total gastrectomy for early gastric cancer
Authors: Kitamura Kazuya , Yamaguchi Toshiharu , Okamoto Kazuma , Taniguchi Hiroki , Hagiwara Akeo , Sawai Kiyoshi , Takahashi Toshio 
Published: February 2007

AbstractA total gastrectomy was performed in 49 patients with early gastric cancer, and the effectiveness of this procedure was evaluated by reviewing the hospital files of the patients. The reasons for this total gastrectomy were as follows: (1) lymph node dissection for 22 patients, (2) surgeon's choice in reconstruction for 10 patients, (3) modification of the surgery from subtotal to total gastrectomy for seven patients, (4) synchronous multiple cancers for seven patients, and (5) cancer in a stomach remnant for three patients. Of 49 patients, 42 had the cancerous lesions in the upper portion of their stomachs. Lymph node involvement occurred in 5 patients, but not in the supra‐ or infrapyloric lymph nodes. Postoperative complications such as anastomotic leakage, reflux esophagitis and pancreatic fistula occurred in five, four, and two patients, respectively. Postoperative death, including two patients who died within 30 days after the surgery, occurred in 5 patients. Our study showed that total gastrectomy resulted in excessive unnecessary surgery in 39 out of 49 patients (79.6%). We conclude that a total gastrectomy should not be performed on patients with early gastric cancer except for synchronous multiple cancers and for cancers in a stomach remnant. © 1995 Wiley‐Liss, Inc.
Acute appendicitis secondary to metastatic nasopharyngeal carcinoma
Authors: Hsu Kuan‐Long , Wang Kwo‐Syin , Chen Leung , Chou Fong‐Fu 
Published: February 2007

AbstractThis is a review of a rare case of acute appendicitis secondary to metastatic nasopharyngeal carcinoma (NPC) that had never before been reported in the literature. The clinical presentation did not differ from usual cases of acute appendicitis, but the pathology caused us to re‐evaluate the NPC Stage of the patient. © 1995 Wiley‐Liss, Inc.
Argyrophilic nucleolar organizer region (AgNOR) area per nucleus as a prognostic factor in breast cancer
Authors: Nakayama Kouichi , Abe Rikiya 
Published: February 2007

AbstractWhether argyrophilic nucleolar organizer region (AgNOR) is a predictor of prognosis in breast cancer is controversial. The semiquantitative procedure used to calculate interphasic argyrophilic dots optically is neither reliable nor reproducible. We measured the mean area of AgNOR dots, the mean AgNOR area per nucleus (MA), and the mean AgNOR number per nucleus (MN) by automated image analysis in specimens from 131 patients with breast cancer. Higher MA (>7.41 pun2), detected in 22 (16.8%) of 131 patients, did not correlate with clinicobiologic variables, except for DNA ploidy status. Overall survival was significantly better in patients with lower MA than in those with higher MA. On multivariate analysis, MA was a significant independent factor, followed by nodal status.These findings indicate that expression of AgNOR should be evaluated in terms of area occupied and that the mean area of AgNOR per nucleus (MA) is an important prognostic factor in the overall survival of breast cancer patients. © 1995 Wiley‐Liss, Inc.
The combination 5‐fluorouracil/levamisole induces enhanced rat kupffer cell‐mediated cytotoxicity in vitro against the syngeneic colon adenocarcinoma cell line CC531
Authors: Schuurman Bart , Sirovich Igor , Heuff Gijsbert , Van Wilt Clasina L. Der , Peters Godefrinus J. , Beelen Robert H. J. , Meyer Sybren 
Published: February 2007

AbstractThe mode of action of the combination treatment 5‐fluorouracil (5‐FU) and levamisole in colorectal cancer patients is unknown. It is postulated that the beneficial effect may be explained by an immunomodulatory effect on Kupffer cell (KC) cytotoxicity. We evaluated the effect of levamisole (200 (μg/ml) and 5‐FU (10 μM) on rat KC cytotoxicity against syngeneic CC531 tumor cells. Viability of KCs was unaffected by 5‐FU and/or levamisole. The combination did not enhance growth inhibition of CC531 compared to 5‐FU alone. A significant increase in KC cytotoxicity was observed after 24‐hr incubation with 5‐FU/levamisole especially at an effector/target ratio of 10 (P < 0.05). 5‐FU alone had no effect on KC cytotoxicity, while levamisole induced only a slight increase. Our in vitro data suggest that the additive effect of the combination 5‐FU/levamisole on KC cytotoxicity may attribute to the beneficial effect of the adjuvant treatment in colorectal cancer patients. © 1995 Wiley‐Liss, Inc.
Prognostic evaluation of lymphadenectomy for epithelial ovarian cancer
Authors: Kikkawa Fumitaka , Ishikawa Hisatake , Tamakoshi Koji , Sucanuma Nobuhiko , Mizuno Kimio , Kawai Michiyasu , Arm Yoshitaro , Tamakoshi Akiko , Kuzuya Kazuo , Tomoda Yutaka 
Published: February 2007

AbstractBetween 1989 and 1991, 150 patients with ovarian cancer were treated with chemotherapy, including cisplatin, in the Tokai Ovarian Tumor Study Group. Of these patients, 25 underwent cytoreductive surgery with lymphadenectomy, including removal of either pelvic or para‐aortic lymph nodes, and 36 underwent both lymphadenectomies. A significant difference was observed between survival curves of the groups with positive and negative lymph nodes, respectively (P = 0.0049). The overall survival was longer in the lymphadenectomy group than in the nonlymphadenectomy group (P = 0.0842), and a significantly longer survival time was noted for stage III patients who underwent lymphadenectomy compared to those who did not (P = 0.0185). Multivariate analysis demonstrated that lymphadenectomy is a positive prognostic factor. The authors conclude that both pelvic and para‐aortic lymph nodes should be resected to improve survival as well as to assess exact staging in patients with ovarian cancer. © 1995 Wiley‐Liss, Inc.
Treatment of radiation‐induced dermatitis with light‐emitting diode (LED) photomodulation
Authors: DeLand M. Maitland , Weiss Robert A. , McDaniel David H. , Geronemus Roy G. 
Published: February 2007

AbstractBackground and ObjectiveLight‐emitting diode (LED) photomodulation increases dermal collagen and reduces inflammation. This study evaluated the use of LED photomodulation in the prevention of radiation‐induced dermatitis in breast cancer.Materials and MethodsPatients (n = 19) were treated with LED photomodulation (Gentlewaves™, Light BioScience, LLC, Virginia Beach, VA) after each of a series of intensity‐modulated radiation treatments (IMRT). Skin reactions were monitored weekly with National Cancer Institute (NCI) criteria. Age‐matched controls (n = 28) received IMRT without LED photomodulation.ResultsIn LED‐treated patients, 18 (94.7%) had grade 0 or 1 reaction and 1 (5.3%) had grade 2 reaction. Among controls, 4 (14.3%) had a grade 1 reaction, 24 (85.7%) had a grade 2 or 3 reaction. One LED‐treated patient (5.3%) and 19 controls (67.9%) had to interrupt treatment.ConclusionLED photomodulation treatments immediately after IMRT reduces the incidence of NCI grades 1, 2, and 3 skin reactions in patients with breast cancer treated by radiation therapy (RT) postlumpectomy. Lasers Surg. Med. 39:164–168, 2007. © 2007 Wiley‐Liss, Inc.
Effects of femtosecond laser irradiation on osseous tissues
Authors: Girard B. , Yu D. , Armstrong M.R. , Wilson B.C. , Clokie C.M.L. , Miller R.J. Dwayne 
Published: February 2007

AbstractBackground and ObjectiveFew studies have investigated femtosecond (fs) lasers for cutting bone tissue.Study Design/Materials and MethodsA 775 nm, 1 kHz, 200 femtosecond, up to 400 µJ laser system was used to irradiate in vitro calcified cortical bone samples and bone tissue culture samples.ResultsThe ablation threshold in cortical bone was 0.69±0.08 J/cm2 at 775 nm and 0.19±0.05 J/cm2 at 387 nm. Plasma shielding experiments determined that the ablation plume and the plasma significantly affect material removal at high repetition rates and appear to generate thermal transients in calcified tissue. Confocal analysis revealed intact enzymatic activity on the surface of cells immediately adjacent to cells removed by fs laser irradiation.ConclusionsThese experiments demonstrate that fs lasers used for bone tissue cutting do not appear to generate significant temperature transients to inactivate proteins and that cellular membrane integrity is disrupted for only a few cell layers. Lasers Surg. Med. 39:273–285, 2007. © 2007 Wiley‐Liss, Inc.