bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidence and risk factors of myelosuppression of linezolid in patients with drug-resistant tuberculosis: A scoping review
Authors: Putra Oki Nugraha , Purnamasari Telly 
Published: March 2024

Background:Drug-resistant tuberculosis (DR-TB) poses a significant global health challenge, requiring prolonged treatment with multiple second-line anti-tuberculosis drugs. Among these medications, bedaquiline and linezolid have shown promising outcomes. However, the primary adverse effects of linezolid leading to dose reduction or early discontinuation is myelosuppression.Methods:This study involved a comprehensive review to evaluate the incidence and risk factors of linezolid-induced myelosuppressionin patients with DR-TB in bedaquiline-based regimens. Furthermore, the procedure adhered to the Systematic Reviews and Meta-Analyses (PRISMA) guideline for a scoping review.Results:The results showed that nine cohort studies met the inclusion criteria. Among the 3310 DR-TB patients in these studies, 661 (19.9%) had HIV. The incidence of myelosuppression ranged from 5.1% to 49.0%, with anemia being the most prevalent case, ranging from 2.9% to 39.0%. According to the reports, linezolid interruption, such as dose adjustments or complete discontinuation ranged from 20.5% to 23.6%. Myelosuppression occurred within a period less than three months on average. Several factors were identified as influencing myelosuppression (anemia) in DR-TB patients within these regimens, including age ≥ 60, concurrent treatment with zidovudine in HIV positive patients, and linezolid concentrations > 2 mg/L. No studies reported mortality cases associated with linezolid.Conclusions:The incidence of myelosuppression was relatively high in DR-TB patients with regimen containing linezolid. Anemia was the most prevalent symptom of myelosuppression during treatment, leading to early discontinuation of linezolid. It indicates that hematologic parameter should be closely supervised, especially in patients with risk factors during linezolid treatment.
PERAN MASYARAKAT DALAM PENYELENGGARAAN PERLINDUNGAN ANAK MENURUT UNDANG-UNDANG PERLINDUNGAN ANAK
Authors: Deshaini Liza 
Published: March 2024

Abstrak
Perlindungan terhadap anak adalah segala kegiatan umtuk menjamin dan melindungi anak dan hak-haknya agar dapat hidup, tumbuh, berkembang, dan berpartisipasi, secara op[timal sesuai dengan harkat dan martabat kemanusiaan, serta mendapat perlindungan dari kekerasan dan diskriminasi. Peran masyarakat dalam penyelenggaraan perlindungan anak dilakukan dengan cara memberikan informasi melalui sosialisasi dan edukasi mengenai hak anak dan peraturan perundang-undangan tentang anak, memberikan masukan dalam perumusan kebijakan yang terkait perlindungan anak, melaporkan kepada pihak berwenang jika terjadi pelanggaran hak anak, berperan aktif dalam proses rehabilitasi dan reintegrasi sosial bagi anak , melakukan pemantauan, pengawasan dan ikut bertanggungjawab terhadap
penyelenggaraan perlindungan anak, menyediakan sarana dan prasaranan serta menciptakan suasana kondusif untuk tumbuh kembang anak, berperan aktif dengan menghilangkan pelabelan negatif terhadap anak korban, memberikan ruang kepada anak untuk dapat berpartisipasi dan menyampaikan pendapat dan akibat hukum terhadap pelaku yang memperlakukan anak secara diskriminatif sehingga anak mengalami kerugian materiil, moril serta menghambat fungsi sosialnya adalah dipidana dengan pidana penjara paling lama 5 (lima) tahun dan/atau denda paling banyak Rp 100.000.000,00 (seratus juta rupiah).
Kata Kunci : Masyarakat, Peran, Perlindungan Anak

Abstract
Protection of children is all activities to guarantee and protect children and their rights so that they can live, grow, develop, and participate optimally in accordance with human dignity and protection from violence and discrimination. The role of the community in the implementation of child protection is carried out by providing information through socialization and education regarding children's rights and laws and regulations regarding children, providing input in the formulation of policies related to child protection, reporting to the authorities in case of violations of children's rights, taking an active role in the process. rehabilitation and social reintegration for children, monitoring, supervising and taking responsibility for implementation of child protection, providing facilities and infrastructure as well as creating a conducive atmosphere for children's growth and development, playing an active role by eliminating negative labeling of child victims, providing space for children to be able to participate and express opinions and legal consequences against perpetrators who treat children discriminatory so that children experience material, moral and social losses are punishable by a maximum imprisonment of 5 (five) years and/or a maximum fine of Rp. 100,000,000.00 (one hundred million rupiah).
Quality of Life among Type II Diabetes Mellitus Patients Using the Modified Diabetes Quality of Life (MDQOL-17): An Observational Study
Authors: Singh Dr. Simran , Mishra Dr. Simran , Rai Dr. Sana , Ganvir Dr. Suvarna 
Published: March 2024

Background: Diabetes mellitus (DM) is a chronic disorder that requires constant management. To achieve good metabolic control and avoid acute and chronic complications, the patient must follow a diet plan, up their physical activity, and take medication. A growing amount of research on the impact of diabetes on health-related quality of life. Patient health, complications, and attitude all have an effect on health-related quality life of either directly or indirectly. Aim: To find out which aspects of life are commonly affected among patients with Diabetes using MDQoL-17 scale. Methodology: 100 patients with Diabetes Mellitus type II participated in the study. Patients with associated comorbid conditions were excluded. MDQoL-17 Scale was then administered on the patients. The entire inquiry was delivered in a language that the patient could understand, and their responses were recorded on the scale. Each domain's percentage of the overall score was computed. Results: According to the answer to the affirmative question number 4, which indicates daily activity, more patients in this study engaged in daily activities that improved their quality of life (75%) than did not. According to the results of negative question 16 (which implies financial stress), (56%) of the patients had this problem, making it difficult for them to receive the appropriate care. Conclusion: Study concludes that specific aspects of QOL that has been found affected than other after diabetes are Physical, Role Physical, Role Emotional, Social and General Health. Resolution of the factors associated with these aspects will help to improve the quality of life in these patients
Pengaruh Pendidikan Kesehatan Reproduksi tentang Pernikahan Dini Terhadap Pengetahuan dan Sikap Remaja
Authors: Aprianti Nurannisa Fitria , Yusuf Nurlathifah N. , Faizaturrahmi Eka 
Published: March 2024

Background : In Indonesia, there are more than one million women aged 20-24 whose first marriage occurred at the age of less than 18 years (1.2 million people). Early marriage is carried out by someone who is under the age of 19 and is not ready in various aspects of marriage. This is likely to have an impact on reproductive health for both men and women.
Objective : to determine the effect of reproductive health education on early marriage on the knowledge and attitudes of adolescents in the working area of ​​the twin bridge health center in 2022. Methods : Pre Experimental research design with one group pretest-Posttest study in March-July 2022. The population in this study was male and female youth. The number of samples in this study were 30 respondents. The sampling technique uses stratified random sampling. The instrument in this study used a questionnaire. Data analysis used the Wilcoxon statistical test. Result: there is an effect of reproductive health education about early marriage on knowledge p 0.00 < α 0.05 and attitude .00 < α 0.05 adolescents in the working area of ​​the twin bridge health center. Conclucion : Reproductive health education about early marriage in adolescents influences the knowledge and attitudes of adolescents
Formulasi dan Evaluasi Gel Pelembap Ekstrak Mesokarp Semangka [Citrullus lanatus (Thunb.) Matsum. & Nakai] sebagai Antioksidan
Authors: Okzelia Sari Defi , Mardiyyah Waffiyyatul 
Published: March 2024

Dry skin is the most common skin problem, so moisturizers are used to prevent it. White skin (mesocarp) of watermelon [Citrullus lanatus (Thunb.) Matsum. & Nakai] (MW) has the potential to be formulated into a moisturizing gel preparation since it contains vitamins and citrulline which also possess antioxidant activity. This study aimed to formulate a moisturizing gel preparation from MW extract as an antioxidant. MW was extracted by maceration using 70% ethanol and formulated into moisturizing gel preparation at concentrations of 5% (F1), 10% (F2), and 15% (F3). Gel preparations were evaluated physically, and determined their moisture content and antioxidant activity. MW extract was a brown color with 25.02% yield. The evaluation results showed that all formulations met the standard parameters of good gel preparations including organoleptic, homogeneity, spread-ability, adhesion, pH, and viscosity, and did not irritate the skin. The skin moisture after application of F1, F2, and F3 respectively were 29.49%; 36.63%; and 43.48%. IC50 values for F1, F2, and F3 respectively were 156.42; 149.24, and 138.05 µg/mL. The moisturizing gel preparation from MW extract met all the standard parameters of good gel preparation, could increase the percentage of skin moisture, and had moderate antioxidant activity.
Persepsi Kepuasan Pasien BPJS Kesehatan dan Dimensi Kualitas Pelayanan Rumah Sakit Umum Daerah
Authors: Amalia Momen , Tulit Christa Bernadeth Ina , Nursapriani Nursapriani 
Published: March 2024

Health service satisfaction is determined by the perception or performance of services in meeting patient expectations. The purpose of this study was to determine the effect of BPJS Kesehatan patients perception on patient satisfaction based on the dimensions of service quality at Labuang Baji Hospital. This research uses quantitative methods with a Cross Sectional Study design. The sample of this study was BPJS Health Patients at Labuang Baji Hospital totaling 87 respondents. Data analysis using Chi-Square test. The results of this study indicate that there is an influence between BPJS Health patient perceptions of patient satisfaction based on the responsiveness dimension with p value 0.001< 0.05, reliability p value 0.002 < 0.05, assurance p value 0.008 < 0.05, empathy p value 0.002 < 0.05. On the tangible dimension thereis no significant effect on patient satisfaction with a p value of 0.064 > 0.05. The variable that has the greatest influence on patient satisfaction is the responsiveness dimension with a p value (sig) of 0.001 < 0.05. The results of this study are the dimensions of responsiveness, reliability, assurance, empathy are variable that have an influence on patient satisfaction while tangible have no effect on patient satisfaction at Labuang Baji Hospital. It is suggested to the RSUD Labuang Baji to improve the quality of service and get a good perception from the patient.
Comparison of three different doses of cis-atracurium under isoflurane anesthesia
Authors: Parpucu Ümit Murat 
Published: March 2024

Aims: In this study; we compared the effects of three different doses of cis-atracurium, a nondepolarizing muscle relaxant agent, on neuromuscular blockade duration, endotracheal intubation quality and hemodynamic parameters under isoflurane anaesthesia.
Methods: A total of 60 patients (ASA I-II) were included in the study. Patients were premedicated with 10 mg diazepam intramuscularly 45 minutes before the operation. After the patients were transferred to the operating room, they were monitored noninvasively for heart rate and arterial blood pressure. Train of Four (TOF)-GUARD acceleration monitor was used for neuromuscular evaluation. All patients were administered 1 mg/kg fentanyl and 2 mg/kg propofol at induction, and anaesthesia maintenance was provided with 1.5% isoflurane+50% N2O+50% O2. The patients were divided into three groups according to the dose of cisatracurium administered: 0.15 mg/kg was administered to Group 1, 0.20 mg/kg was administered to Group 2, and 0.40 mg/kg cis-atracurium was administered to Group 3. Endotracheal intubation was performed at 120 seconds, and the block time of 99-100% (effect onset time) was recorded.
Result: Although the endotracheal intubation quality was evaluated as excellent and/or good in all three groups, the intubation quality of Group 3 was statistically higher than the other two groups (p
Diagnostic performance of whole blood viscosity indices in predicting the presence and severity of coronary artery disease
Authors: Kıvrak Ahmet , Yıldırım Alp 
Published: March 2024

Aims: Growing evidence suggests that blood viscosity plays a crucial role in both the development and acceleration of atherosclerosis. In this study, aimed to investigate the diagnostic performance of the mean platelet volume-age-total protein-hematocrit (MAPH) score, a new index for blood viscosity, in predicting the presence and severity of CAD in patients with suspected coronary artery disease (CAD).
Methods: We retrospectively evaluated 431 patients who underwent coronary angiography. SYNTAX score (SS) were divided into 3 groups; low group (
The Role of Government Intervention in Mitigating Economic Shocks
Authors: Mutoni Kate 
Published: March 2024

Purpose: This study sought to explore the role of government intervention in mitigation economic shocks.
Methodology: The study adopted a desktop research methodology. Desk research refers to secondary data or that which can be collected without fieldwork. Desk research is basically involved in collecting data from existing resources hence it is often considered a low cost technique as compared to field research, as the main cost is involved in executive’s time, telephone charges and directories. Thus, the study relied on already published studies, reports and statistics. This secondary data was easily accessed through the online journals and library.
Findings: The findings reveal that there exists a contextual and methodological gap relating to the role of government intervention in mitigating economic shocks. Preliminary empirical review that government intervention plays a crucial role in stabilizing economies during periods of turbulence. Through an exploration of theories such as Keynesian economics, Monetarism, and New Classical Economics, it was found that a balanced approach utilizing both fiscal and monetary policies is effective in responding to economic challenges. Sector-specific impacts were also highlighted, showing that targeted government support, such as subsidies and effective regulation, can enhance resilience in sectors like manufacturing and energy. The study's findings suggest that policymakers should adopt evidence-based strategies to navigate economic uncertainties and promote sustainable growth and stability.
Unique Contribution to Theory, Practice and Policy: Keynesian Economics, Monetarism and the New Classical Economics model may be used to anchor future studies on the role of government intervention in mitigating economic shocks. The study made significant contributions by offering recommendations for policymakers and practitioners. It enhanced economic theory by synthesizing Keynesian economics, Monetarism, and New Classical Economics, providing insights into effective policy responses to economic crises. The study emphasized the importance of targeted government spending, a combination of monetary and fiscal policies, clear guidelines for bailouts, and building economic resilience through diversification and innovation. It also highlighted the need for stable regulatory frameworks, addressing inequality, and taking a holistic approach to policy-making. These recommendations have guided past policy decisions, helping to promote economic stability and resilience.
Keywords: Government Intervention, Economic Shocks, Keynesian Economics, Monetarism, Fiscal Policy, Monetary Policy
Crisis Communication and Reputation Management in the Age of Fake News
Authors: Gasana Kelly 
Published: March 2024

Purpose: This study sought to determine how different crisis communication approaches impact reputation management, particularly in the context of fake news.
Methodology: The study adopted a desktop research methodology. Desk research refers to secondary data or that which can be collected without fieldwork. Desk research is basically involved in collecting data from existing resources hence it is often considered a low cost technique as compared to field research, as the main cost is involved in executive’s time, telephone charges and directories. Thus, the study relied on already published studies, reports and statistics. This secondary data was easily accessed through the online journals and library.
Findings: The findings reveal that there exists a contextual and methodological gap relating to crisis communication and reputation management in the age of fake news. Preliminary empirical review revealed that that organizations needed to adapt their communication strategies to combat the challenges posed by misinformation. The research highlighted the pervasive impact of fake news on organizational reputation, emphasizing the importance of transparency, authenticity, and responsiveness in crisis communication. Leadership played a crucial role in guiding effective crisis responses, fostering trust, and demonstrating a commitment to ethical communication practices. Overall, the study provided valuable insights and recommendations for organizations to navigate crises fueled by fake news and safeguard their credibility in the digital age.
Unique Contribution to Theory, Practice and Policy: The Situational Crisis Communication Theory (SCCT), Agenda Setting theory and the Social Identity theory may be used to anchor future studies on crisis communication and reputation management. The study contributed significantly to theoretical understanding, practical application, and policy development. It enhanced existing theoretical frameworks such as Situational Crisis Communication Theory (SCCT), Agenda-Setting Theory, and Social Identity Theory by integrating considerations specific to managing crises exacerbated by fake news. The study provided valuable insights and recommendations for communication professionals, emphasizing proactive media monitoring, transparency, and leadership in guiding crisis communication efforts. Additionally, it informed policy interventions aimed at combating misinformation and promoting responsible communication practices. Overall, the study served as a valuable resource for stakeholders navigating the complexities of crisis communication and reputation management in the digital age.
CHEMICAL FEATURES OF FOREWING SCALES OF Leptosia nina Fabricius, 1793 (Lepidoptera: Pieridae)
Authors: Thaj Amina , Prasad G 
Published: March 2024

The functional groups have a vital role in insect physiology, behaviour, and adaptation to the environment and are crucial in biomimetics to replicate and adapt biological functions for diverse use ranging from medicine to material science and energy technologies. A study was conducted on Leptosia nina forewing scales to assess its chemical composition spectra using Fourier Transform Infrared Spectroscopic (FTIR) analysis. The identified functional groups from dorsal white, dorsal black spot, ventral white and ventral black spot areas of L. nina forewing composed of alcohols, phenols, aldehydes, aliphatic amine, alkanes, alkenes, alkyl halides, alkynes, aromatic groups,carboxylic acid groups, nitro compounds, amines, ester and ether with various stretches. The spectra showed minor variations in peaks in the four regions studied. The study is the first record revealing the functional groups of L. nina forewing scales.
In vitro ANALYSIS OF BIOFILM FORMATION AND ANTIBIOTIC RESISTANCE OF UROPATHOGENIC Escherichia coli
Authors: Reshma A Amala , Andrew S Niren , Saradhai P , Sasikala S 
Published: March 2024

Urinary tract infections are an exceedingly common worldwide problem, caused mostly by Gram-negative bacteria, especially Escherichia coli. Microbial biofilms are considered a serious public health problem. The potential of uropathogenic E. coli (UPEC) to produce biofilm was explored in the present study. The Congo red agar, tube- and tissue culture plate methods were used to evaluate the formation of biofilm by E. coli isolates. Of the 155 isolates, 101, 106 and 90 isolates were positive for these three methods, respectively. Subsequently, the sensitivity of E. coli isolates to antimicrobial agents (amikacin, cefepime, cefixime, cefotaxime, cefpodoxime, ceftazidime, ceftriaxone, ciprofloxacin, nitrofurantoin, gentamycin, nalidixic acid, ofloxacin and pefloxacin) was tested. There was no difference in the rate of biofilm detection between Congo red agar method and tube method. The antibiotic sensitivity test revealed that the biofilm producing isolates were multi-drug resistant. The study emphasized the necessity for developing alternative therapeutic approaches to overcome multi drug resistance arising from biofilm formation of UPEC.
Das Mikrobiom interessiert die Bohne
Authors: Schaal René 
Published: March 2024

Frankfurt a.M. Die Züchtung von Kulturpflanzen aus Wildpflanzen hat zahlreiche Veränderungen in deren Eigenschaften bewirkt. Eine kürzlich im Fachjournal Current Biology veröffentlichte Studie zeigt, dass sich auch das Mikrobiom, also die Gesamtheit aller Mikroorganismen, auf den Samen dieser Pflanzen verändert hat. Die Erkenntnisse könnten positive Auswirkungen auf die moderne Landwirtschaft haben.
LIFE SKILL TRAINING BERBASIS AQUASCAPE PADA PEMUDA NARAPIDANA KASUS NARKOBA DI LAPAS I KOTA MADIUN UNTUK MEWUJUDKAN SDGS
Authors: Ayu Safitri Ayu , Rahmawati Pebriani , Pratiwingtyas Lavenia , Rahma Hidayat Fajar , Lusiana Restu 
Published: March 2024

Abstrak
Life skill training berbasis aquascape ini merupakan sebuah pelatihan yang tidak hanya meningkatkan keterampilan, namun juga mengasah kemampuan, keberanian, dan kepercayaan diri pemuda narapidana kasus narkoba. Tujuan kegiatan ini adalah dapat memberikan bekal kepada pemuda narapidana kasus narkoba Lapas I Kota Madiun dalam menjalankan kehidupannya dengan lebih baik setelah menyelesaikan masa hukumannya dan dapat diterima oleh masyarakat kembali. Kegiatan ini menggunakan 5 metode yaitu tahap mengukur permasalahan atau kebutuhan mitra, tahap merealisasikan kegiatan, tahap pengukuran dan pengevaluasian kegiatan, tahap solusi inti kegiatan, tahap konstribusi pihak-pihak yang dipertimbangkan. Hasil kegiatan tersebut adalah warga binaan narapidana narkoba mendapatkan keterampilan baru dalam bidang aquascape, mendapatkan keterampilan dalam menciptakan peluang usaha dan mendapatkan keterampilan dalam pemasaran produk baik secara langsung maupun secara online. Kegiatan tersebut dapat memperbaiki kondisi ekonomi warga binaan narkoba Lapas I Kota Madiun dalam sector industry kreatif.

Kata Kunci: Aquascape, Warga Binaan Narkoba, Lapas I Kota Madiun, Industri Kreatif