bluuebunny/crossref_metadata_2025_split huggingface dataset:
Translation Policy and the Politics of Translation—The Translation of Power Relationships: An Afterword
Authors: Flüchter Antje , Lüsebrink Hans-Jürgen 
Published: March 2024

AbstractComplementing the deliberations set forth in the foreword, the afterword focuses on four strands of theoretically oriented reflection: to begin with, theoretical reflection on the relationship between translation, politics, and power as discussed by Michel Foucault, a relationship manifest in various phenomena such as political influence on translation projects or the cultural hegemony of certain source and target languages in translation. The second strand of reflection has to do with the role of different semiotically conceived materialities and text types in the context of translation, which implies a necessary systematic expansion of the traditional concept of translation beyond verbal and writing-based signs. Thirdly, we reflect on translation here as a complex (inter-)cultural contact zone in which, on closer examination, transcultural and power-determined processes of meaning negotiation—processes as diverse as they are ambivalent—can be observed between the poles of “domestication” and “foreignization” often schematically distinguished in the research discussion. And fourthly we are concerned with reflection on “historicity and anachronism”, particularly with regard to the problem of Eurocentrism and its epistemologically distortive influence on the historical analysis of translation processes.
Glottopolitik und Translationspolitik in Neu-Spanien. Der Einfluss des ‚miserables-Diskurses‘ auf koloniale Translationspraktiken
Authors: Schrader-Kniffki Martina , Klamp Yannic , Kneifel Malte 
Published: March 2024

ZusammenfassungThis article revolves around translation politics as a consequence of colonial politics in New Spain. The colonizers categorized the indigenous population as personas miserables, a juridical term which had emerged in Europe. We examine the influence of this label on translation practices taking place in the context of the Catholic mission as well as in the juridical and notarial sphere. To this end, we analyze Spanish-Zapotec documents dating from the sixteenth to eighteenth centuries from Oaxaca, Mexico. The hypothesis is that this ambiguous status, which characterizes the population as immature and in need of protection, shaped translation procedures in translations into Zapotec, but also created scope for the indigenous population to participate in political decision-making processes, as can be demonstrated on the basis of translations from Zapotec into Spanish.
Einleitung
Authors: Höhl Karolin , Dreyer Jana , Lichtenstein Silke 
Published: March 2024

ZusammenfassungEssen ist politisch geworden (Schröder, 2016). Und das nicht erst, seitdem im Auftrag der Deutschen Bundesregierung eine Ernährungsstrategie aufgelegt wurde (Bundesministerium für Ernährung und Landwirtschaft, 2024) und es im Auftrag des Deutschen Bundestages den ersten „Bürgerrat Ernährung im Wandel“ gibt (Mehr Demokratie et al., 2023).
Diskussion
Authors: Höhl Karolin , Dreyer Jana , Lichtenstein Silke 
Published: March 2024

ZusammenfassungDie vorliegende, multidisziplinäre Betrachtung von Theorien im Kontext von Werten hat gezeigt, dass eine transdisziplinär anwendbare und interdisziplinär anerkannte Auffassung fehlt. Der vorliegende Text hat für dieses „Phänomen“ zahlreiche Erläuterungen gegeben, so bspw., dass die Bedeutsamkeit und Auslegung eines Wertes unter der jeweiligen Perspektive des wertenden aber auch des bewerteten Subjektes zu erfolgen hat.
Telemedizin bei Fazialisparese
Authors: Ballmaier Jonas , Hölzer Sabrina , Geitner Maren , Kuttenreich Anna-Maria , Erfurth Christian , Guntinas-Lichius Orlando , Volk Gerd Fabian 
Published: March 2024

ZusammenfassungAuch in der Medizin gewinnt die Digitalisierung immer schneller an Bedeutung. Die COVID-19-Pandemie beschleunigte diesen Prozess zusätzlich, und die Politik versucht, Rahmenbedingungen für einen erfolgreichen Wissenstransfer und eine bessere digitale medizinische Versorgung zu schaffen. Im vorliegenden Artikel wird die Rolle der Telemedizin bei der Behandlung von Patientinnen und Patienten mit Fazialisparese erörtert. Eine Fazialisparese hat vielfältige Auswirkungen, von Einschränkungen der Gesichtsbeweglichkeit bis zu psychologischen Folgeerkrankungen. Während viele der akuten idiopathischen Fazialisparesen sich nach einigen Wochen bessern, entwickeln etwa ein Drittel der Betroffenen Synkinesien, unwillkürliche Mitbewegungen, welche lebenslange funktionelle und psychologische Folgen haben. Die Therapie umfasst verschiedene Modalitäten, über Medikamente und Chirurgie bis zum Bewegungstraining. Bei regionaler Unterversorgung, aber auch in der Versorgung chronischer Fazialisparesen, bietet die Telemedizin innovative Lösungsansätze. Der Artikel definiert den Begriff „Telemedizin“ im aktuellen Kontext und zeigt verschiedene Anwendungsarten auf. Eine detaillierte Analyse der Anwendungsszenarien von Telemedizin bei Patientinnen und Patienten mit Fazialisparese zeigt, dass trotz geringer Evidenz viele potenziell nützliche Konzepte existieren.
Dosimetry and pharmacokinetics of [177Lu]Lu-satoreotide tetraxetan in patients with progressive neuroendocrine tumours
Authors: Schürrle Seval Beykan , Eberlein Uta , Ansquer Catherine , Beauregard Jean-Mathieu , Durand-Gasselin Lucie , Grønbæk Henning , Haug Alexander , Hicks Rodney J. , Lenzo Nat P. , Navalkissoor Shaunak , Nicolas Guillaume P. , Pais Ben , Volteau Magali , Wild Damian , McEwan Alexander , Lassmann Michael 
Published: March 2024

Abstract
Purpose
To evaluate the dosimetry and pharmacokinetics of the novel radiolabelled somatostatin receptor antagonist [177Lu]Lu-satoreotide tetraxetan in patients with advanced neuroendocrine tumours (NETs).

Methods
This study was part of a phase I/II trial of [177Lu]Lu-satoreotide tetraxetan, administered at a median cumulative activity of 13.0 GBq over three planned cycles (median activity/cycle: 4.5 GBq), in 40 patients with progressive NETs. Organ absorbed doses were monitored at each cycle using patient-specific dosimetry; the cumulative absorbed-dose limits were set at 23.0 Gy for the kidneys and 1.5 Gy for bone marrow. Absorbed dose coefficients (ADCs) were calculated using both patient-specific and model-based dosimetry for some patients.

Results
In all evaluated organs, maximum [177Lu]Lu-satoreotide tetraxetan uptake was observed at the first imaging timepoint (4 h after injection), followed by an exponential decrease. Kidneys were the main route of elimination, with a cumulative excretion of 57–66% within 48 h following the first treatment cycle. At the first treatment cycle, [177Lu]Lu-satoreotide tetraxetan showed a median terminal blood half-life of 127 h and median ADCs of [177Lu]Lu-satoreotide tetraxetan were 5.0 Gy/GBq in tumours, 0.1 Gy/GBq in the bone marrow, 0.9 Gy/GBq in kidneys, 0.2 Gy/GBq in the liver and 0.8 Gy/GBq in the spleen. Using image-based dosimetry, the bone marrow and kidneys received median cumulative absorbed doses of 1.1 and 10.8 Gy, respectively, after three cycles.

Conclusion
[177Lu]Lu-satoreotide tetraxetan showed a favourable dosimetry profile, with high and prolonged tumour uptake, supporting its acceptable safety profile and promising efficacy.

Trial registration
NCT02592707. Registered October 30, 2015.
Choroidal hypertransmission width on optical coherence tomography: a prognostic biomarker in idiopathic macular hole surgery
Authors: Alkabes Micol , Rabiolo Alessandro , Govetto Andrea , Fogagnolo Paolo , Ranno Stefano , Marchetti Mattia , Frerio Filippo , Wild Davide , Gatti Valentina , Muraca Andrea , De Cillà Stefano 
Published: March 2024

Abstract
Purpose
To test the hypothesis that optical coherence tomography (OCT) choroidal hypertransmission width (CHW) is a prognostic biomarker in idiopathic macular hole (MH) surgery

Methods
Retrospective cohort study of consecutive patients undergoing successful pars plana vitrectomy for idiopathic MH. We collected demographic, clinical, and OCT variables at the preoperative and last available visits. Two investigators assessed the following OCT parameters: MH minimum diameter, base diameter, CHW, ellipsoid zone, and external limiting membrane status (absent vs. present). Delta CHW was calculated as the difference between CHW and MH minimum diameter. Linear models were used to investigate factors associated with postoperative best-corrected visual acuity (BCVA) and BCVA change.

Results
Thirty-six eyes (36 patients) with a median (interquartile range (IQR)) follow-up of 9 (8–11) months were included. The median BCVA (IQR) improved from 0.75 (1–0.6) logMAR preoperatively to 0.2 (0.6–0.1) logMAR at the last visit (p < 0.001). Preoperative MH minimum diameter (for a 10-μm increase, estimate (standard error (SE)): 0.009 (0.003) logMAR, p = 0.003), base diameter (for a 10-μm increase, 0.003 (0.001) logMAR, p = 0.032), CHW (for a 10-μm increase, 0.008 (0.002) logMAR, p < 0.001), and delta CHW (for a 10-μm increase, 0.013 (0.005) logMAR, p = 0.009) were significantly associated with postoperative BCVA. The proportion of variance explained was the highest for MH CHW (R2 0.35), followed by minimum MH diameter (R2 0.24), delta CHW (R2 0.19), and MH base diameter (R2 0.14). None of the study variables was associated with delta BCVA.

Conclusion
Preoperative CHW is associated with postoperative visual acuity in patients undergoing successful idiopathic MH surgery and may be a useful OCT prognostic biomarker.
Risk of HBV reactivation in HCC patients undergoing combination therapy of PD-1 inhibitors and angiogenesis inhibitors in the antiviral era
Authors: Wang Rui , Tan Guili , Lei Dingjia , Li Yadi , Gong JiaoJiao , Tang Yao , Pang Hao , Luo Huating , Qin Bo 
Published: March 2024

Abstract
Background
Although routine antiviral therapy has been implemented in HCC patients, the risk of HBV reactivation (HBVr) remains with the use of programmed cell death-1(PD-1) blockade‐based combination immunotherapy and the relevant risk factors are also unclear. Therefore, we aimed to identify the incidence and risk factors of HBVr in HCC patients undergoing combination therapy of PD-1 inhibitors and angiogenesis inhibitors and concurrent first-line antivirals.

Methods
We included a total of 218 HBV-related HCC patients with first-line antivirals who received PD-1 inhibitors alone or together with angiogenesis inhibitors. According to the anti-tumor therapy modalities, patients were divided into PD-1 inhibitors monotherapy group (anti-PD-1 group) and combination therapy group (anti-PD-1 plus angiogenesis inhibitors group). The primary study endpoint was the incidence of HBVr.

Results
HBVr occurred in 16 (7.3%) of the 218 patients, 2 cases were found in the anti-PD-1 group and the remaining 14 cases were in the combination group. The Cox proportional hazard model identified 2 independent risk factors for HBVr: combination therapy (hazard ratio [HR], 4.608, 95%CI 1.010–21.016, P = 0.048) and hepatitis B e antigen (HBeAg) positive (HR, 3.695, 95%CI 1.246–10.957, P = 0.018). Based on the above results, we developed a simple risk-scoring system and found that the high-risk group (score = 2) developed HBVr more frequently than the low-risk group (score = 0) (Odds ratio [OR], 17.000, 95%CI 1.946–148.526, P = 0.01). The area under the ROC curve (AUC-ROC) was 7.06 (95%CI 0.581–0.831, P = 0.006).

Conclusion
HBeAg-positive patients receiving combination therapy have a 17-fold higher risk of HBVr than HBeAg-negative patients with PD-1 inhibitors monotherapy.
A parametric study of the effect of 3D plaque shape on local hemodynamics and implications for plaque instability
Authors: Hossain Shaolie S. , Johnson Michael J. , Hughes Thomas J. R. 
Published: March 2024

AbstractThe vast majority of heart attacks occur when vulnerable plaques rupture, releasing their lipid content into the blood stream leading to thrombus formation and blockage of a coronary artery. Detection of these unstable plaques before they rupture remains a challenge. Hemodynamic features including wall shear stress (WSS) and wall shear stress gradient (WSSG) near the vulnerable plaque and local inflammation are known to affect plaque instability. In this work, a computational workflow has been developed to enable a comprehensive parametric study detailing the effects of 3D plaque shape on local hemodynamics and their implications for plaque instability. Parameterized geometric 3D plaque models are created within a patient-specific coronary artery tree using a NURBS (non-uniform rational B-splines)-based vascular modeling pipeline. Realistic blood flow features are simulated by using a Navier–Stokes solver within an isogeometric finite-element analysis framework. Near wall hemodynamic quantities such as WSS and WSSG are quantified, and vascular distribution of an inflammatory marker (VCAM-1) is estimated. Results show that proximally skewed eccentric plaques have the most vulnerable combination of high WSS and high positive spatial WSSG, and the presence of multiple lesions increases risk of rupture. The computational tool developed in this work, in conjunction with clinical data, -could help identify surrogate markers of plaque instability, potentially leading to a noninvasive clinical procedure for the detection of vulnerable plaques before rupture.
Hintergrund und methodische Aspekte der S2k-Leitlinie „Erster epileptischer Anfall und Epilepsien im Erwachsenenalter“
Authors: May Theodor W. , Holtkamp Martin 
Published: March 2024

ZusammenfassungSeit September 2023 liegt die neue S2k-Leitlinie „Erster epileptischer Anfall und Epilepsien im Erwachsenenalter“ vor, die die „alte“ S1-Leitlinie ersetzt. Detaillierte Empfehlungen zu vielfältigen Aspekten der Diagnostik, Therapien und Komorbiditäten sowie zu psychosozialen Aspekten der Epilepsie wurden im Rahmen einer strukturierten Konsensusfindung von einer repräsentativen, multiprofessionellen Leitliniengruppe mit 66 Mitgliedern erarbeitet und abgestimmt. Die methodische Vorgehensweise bei der Entwicklung dieser Leitlinie und deren Dokumentation folgte dem
Leitfaden der Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF) zur „Erstellung des Leitlinienreports für für Autor*innen von S2k, S2e und S3-Leitlinien“ und „AWMF-Regelwerk Leitlinien 2.0“ z. B. hinsichtlich der Graduierung der Empfehlungsstärke und der Konsensstärke. Transparenz hinsichtlich potenzieller Interessenkonflikte ist eine wichtige Voraussetzung für die Vertrauenswürdigkeit von Leitlinien und damit auch für deren Akzeptanz. Potenzielle Interessenkonflikte und dadurch bedingte Einschränkungen in der Mitarbeit an der Leitlinienentwicklung sind im Leitlinienreport detailliert dokumentiert. Die Leitlinie wurde durch die DGN und AWMF begutachtet und durch die Vorstände der beteiligten Fachgesellschaften verabschiedet. Der Anspruch der Leitlinie, die medizinische Versorgung von Menschen mit Epilepsie zu verbessern, setzt voraus, dass diese dem Adressatenkreis bekannt ist. Hierzu wurde bzw. wird die Leitlinie auf den Internetseiten der AWMF, Deutschen Gesellschaft für Epileptologie (DGfE), DGN und anderer Fachgesellschaften veröffentlicht. Von der DGfE wurde die Kampagne „Wegweiser Epilepsie“ mit Videoclips und Textbeiträgen auf der Homepage der Fachgesellschaft umgesetzt, um die Leitlinie gegenüber einer größeren Öffentlichkeit bekannt zu machen.
Lethal and sublethal effects of carlina oxide on the aphid Metopolophium dirhodum and its non-target impact on two biological control agents
Authors: Novák Matěj , Pavela Roman , Spinozzi Eleonora , Ferrati Marta , Petrelli Riccardo , Maggi Filippo , Ricciardi Renato , Benelli Giovanni 
Published: March 2024

AbstractThis study was designed to investigate the acute toxicity (mortality) and sublethal effects (fertility and potential natality) of carlina oxide, the main constituent of Carlina acaulis essential oil (EO), against adults of Metopolophium dirhodum (Walker) (Hemiptera: Aphididae). Moreover, its toxicity was evaluated against two aphid natural enemies, i.e., Aphidoletes aphidimyza Rondani (Diptera: Cecidomyiidae) and Chrysoperla carnea Stephens (Neuroptera: Chrysopidae). The highest tested concentration (3.0 mL L−1) resulted in 96.7% mortality of adults of the target pest, highlighting that this concentration of carlina oxide had a similar effectiveness as the positive control we used. Furthermore, probit analysis allowed the estimation of a LC50 of 1.06 mL L−1 and a LC90 of 2.58 mL L−1 for the target pest, which resulted in a much higher mortality rate than that found on natural enemies, i.e., A. aphidimyza (6.7 ± 4.7% ± SD when exposed to the aphid LC90) and C. carnea (7.0 ± 5.5% ± SD when exposed to the aphid LC90), showing the limited non-target impact of carlina oxide. The use of LC30 and LC50 of this compound allowed the fertility inhibition of the target pest by 35.68 ± 6.21% and 23.66 ± 10.58%, respectively, and potential natality inhibition of the target pest by 52.78 ± 4.48% and 59.69 ± 5.60%, respectively. Of note, carlina oxide showed excellent insecticidal activity against M. dirhodum, comparable to the commercial insecticide considered. Overall, the low toxicity of carlina oxide toward A. aphidimyza and C. carnea makes it a safe compound for non-target organisms as well as suitable for developing a green insecticide for the management of M. dirhodum and perhaps other insects of agricultural or medical and veterinary interest.
Tibiofemoral Slip Velocity in Total Knee Arthroplasty is Design-Invariant but Activity-Dependent
Authors: Guan Shanyuanye , Dumas Raphael , Pandy Marcus G 
Published: March 2024

AbstractTibiofemoral slip velocity is a key contributor to total knee arthroplasty (TKA) component wear, yet few studies have evaluated this quantity in vivo. The aim of the present study was to measure and compare tibiofemoral slip velocities in 3 TKA designs for a range of daily activities. Mobile biplane X-ray imaging was used to measure 6-degree-of-freedom tibiofemoral kinematics and the locations of articular contact in 75 patients implanted with a posterior-stabilized, cruciate-retaining, or medial-stabilized design while each patient performed level walking, step up, step down, sit-to-stand, and stand-to-sit. Using these data, tibiofemoral slip velocity was calculated for the duration of each activity for each TKA design. The pattern of tibiofemoral slip velocity was similar for all 3 TKA designs within each activity but markedly different across the 5 activities tested, with the magnitude of peak slip velocity being significantly higher in level walking (range: 158–211 mm/s) than in all other activities (range: 43–75 mm/s). The pattern of tibiofemoral slip velocity in both the medial and lateral compartments closely resembled the pattern of tibiofemoral (knee) flexion angular velocity, with a strong linear relationship observed between slip velocity and flexion angular velocity (r = 0.81–0.97). Tibiofemoral slip velocity was invariant to TKA design but was significantly affected by activity type. Our measurements of slip velocity and articular contact locations for a wide range of daily activities may be used as inputs in joint simulator testing protocols and computational models developed to estimate TKA component wear.
KEYNOTE-434 part B: A phase 1 study evaluating the combination of epacadostat, pembrolizumab, and chemotherapy in Japanese patients with previously untreated advanced non–small-cell lung cancer
Authors: Yamamoto Noboru , Satouchi Miyako , Doi Toshihiko , Fujiwara Yutaka , Yanagitani Noriko , Kawa Yoshitaka , Yoh Kiyotaka , Leopold Lance , Munteanu Mihaela , Sawada Takashi , Han Shirong , Noguchi Kazuo , Nishio Makoto 
Published: March 2024

Abstract
Background
Pembrolizumab plus epacadostat (indoleamine 2,3-dioxygenase-1 inhibitor) was well tolerated in Japanese patients with advanced solid tumors in part A of the nonrandomized, open-label, phase 1 KEYNOTE-434 study (NCT02862457). We report results from part B, which evaluated epacadostat plus pembrolizumab and chemotherapy in Japanese patients with advanced non–small-cell lung cancer (NSCLC).

Methods
Eligible patients aged ≥ 20 years had histologically or cytologically confirmed stage IIIB or IV NSCLC with no prior systemic therapy, and ECOG performance status of 0 or 1. Patients received epacadostat 100 mg orally twice-daily, pembrolizumab 200 mg intravenously every-3-weeks for ≤ 35 cycles, and 4 cycles of chemotherapy (cohort 1: cisplatin plus pemetrexed, non-squamous; cohort 2: carboplatin plus pemetrexed, non-squamous; cohort 3: carboplatin plus paclitaxel, squamous or non-squamous). Primary endpoint was incidence of dose-limiting toxicities (DLTs). Following unfavorable results from other studies, a protocol amendment removed epacadostat from the treatment combination.

Results
Of 19 patients, 7 were enrolled in cohort 1, and 6 each in cohorts 2 and 3. Median follow-up was 13.7 (range, 4.2–27.8) months. Five of 17 (29%) DLT-evaluable patients experienced ≥ 1 DLT (cohort 1, n = 1; cohorts 2 and 3, n = 2 each); most commonly maculopapular rash (grade 3, n = 3) and increased alanine aminotransferase (grade 2, n = 1; grade 3, n = 2). All patients experienced treatment-related adverse events (AEs); 58% experienced grade 3 or 4 treatment-related AEs. Objective response rate was 47%.

Conclusion
The combination of epacadostat plus pembrolizumab and chemotherapy was found to be tolerable in Japanese patients with advanced NSCLC.

Trial registration
ClinicalTrials.gov, NCT02862457.
Effect of four-component binder on characteristics of self-compacting and fibre-reinforced self-compacting mortars
Authors: Venkateswara Rao Sarella , Palou Martin T. , Novotný Radoslav , Žemlička Matúš , Čepčianska Jana , Czirák Peter 
Published: March 2024

AbstractThe hydration heat of a four-component binder consisting of Portland cement (CEM I 42.5 R), blast-furnace slag (BFS), metakaolin (MK), and silica fume (SF) was investigated using a conduction calorimeter and thermal analytical method to optimize the material composition of self-compacting mortar (SCM). Then, the influence of material composition with different substitution levels (0, 25, 30, and 35% labelled as SCM100, SCM75, SCM70, and SCM65) on physical and mechanical properties of the mortars with two volumetric binder sand ratios of 1:1 and 1:2 (cement: sand) was evaluated. Furthermore, two mortar compositions comprising SCM75 and sand at 1:1 and 1:2 ratios were used to prepare fibre-reinforced self-compacting mortars in five combinations (0, 0.25, 0.5, 0.75, and 1%) of two fibres (polypropylene-PPF and basalt-BF) at a constant content of 1.00 vol%. The properties of the prepared samples were investigated with respect to the characteristics of self-compactibility and mechanical properties of fresh and hardened states, respectively. The rheology characteristics expressed by slump flow, V-funnel, and T20 were found following the EFNARC guidance. The partial replacement of cement by supplementary cementitious materials has enhanced the performances (compressive and flexural strengths, dynamic modulus of elasticity) of self-compacting mortars from the 7th day through pozzolanic activity. Furthermore, adding fibres has enhanced the DME and microstructure of the self-compacting mortars.