bluuebunny/crossref_metadata_2025_split huggingface dataset:
Retrospective study of fever in dogs: laboratory testing, diagnoses and influence of prior treatment
Authors: Battersby I. A. , Murphy K. F. , Tasker S. , Papasouliotis K. 
Published: June 2006

Objectives: To analyse the demographic information of dogs referred for investigation of fever, to determine the usefulness of various diagnostic investigations and to assess the effect of treatment before referral on the presence of fever at referral, the duration of the investigation and the ability to reach a final diagnosis. Methods: The clinical records of 66 dogs, in which fever was part of the clinical signs documented by the referring veterinary surgeon, were reviewed. The effects of treatment 24 hours before referral on temperature at initial consultation and on time to diagnosis were evaluated. The effect of body temperature at initial consultation on cost and on time to diagnosis was also determined. The effect of insurance on costs incurred was assessed. The utility of different diagnostic investigations was recorded, and cases were classified according to the final diagnosis. Results: Only 34·8 per cent of dogs were diagnosed with immune‐mediated disease, with most frequent diagnoses being steroid‐responsive meningitis and polyarthritis. Treatment 24 hours before referral significantly increased the time to diagnosis (P=0·004) and affected the presence of fever at referral (P=0·006). Insurance status did not significantly affect cost incurred by the owner.Clinical Significance: This study documents a high incidence of immune‐mediated disease in dogs referred for investigation of fever. It also documents a higher incidence of inflammatory central nervous system disease in febrile dogs than that reported previously. Of the diagnostic modalities employed in the majority of cases, radiography, cytology and bacteriological and fungal cultures (fluids/tissues) were the most useful. It is suggested that treatment is withdrawn or withheld before commencing diagnostic investigation of fever.
Accumulation of p27(kip1) is associated with cyclin D3 overexpression in the oxyphilic (Hurthle cell) variant of follicular thyroid carcinoma
Authors: Troncone G , Iaccarino A , Russo M , Palmieri E A , Volante M , Papotti M , Viglietto G , Palombini L 
Published: June 2006

Background:The down regulation of protein p27kip1(p27) in most cases of thyroid cancer has relevant diagnostic and prognostic implications. However, the oxyphilic (Hurthle cell) variant of follicular thyroid carcinoma expresses more p27 than benign oxyphilic lesions do.Aim:To evaluate the mechanism underlying this difference in expression of p27.Methods:Because high levels of cyclin D3 lead to p27 accumulation in cell lines and clinical samples of thyroid cancer, the immunocytochemical pattern of cyclin D3 in oxyphilic (n = 47) and non-oxyphilic (n = 70) thyroid neoplasms was investigated.Results:In the whole study sample, there was a significant correlation between p27 and cyclin D3 expression (Spearman’s r: 0.64; p<0.001). The expression of cyclin D3 and p27 was significantly higher in the oxyphilic variant of follicular carcinomas than in non-oxyphilic carcinomas (p<0.001). In the former, cyclin D3 overexpression and p27 accumulation were observed in a median of 75% and 55% of cells, respectively. In co-immunoprecipitation experiments, the level of p27-bound cyclin D3 was much higher in oxyphilic neoplasias than in normal thyroids and other thyroid tumours.Conclusion:These results show that increased p27 expression in the oxyphilic (Hurthle cell) variant of follicular thyroid carcinoma results from cyclin D3 overexpression.
Fine-needle aspiration cytology of metaplastic carcinoma of the breast
Authors: Lui Philip C W , Tse Gary M K , Tan Puay Hoon , Jayaram Gita , Putti Thomas C , Chaiwun Benjaporn , Chan Norman H L , Lau Patrick P L , Mak Kong Ling , Khin Aye T 
Published: June 2006

Background:Metaplastic carcinoma of the breast encompasses a heterogeneous group of tumours with variable components of sarcomatoid, squamous or poorly differentiated carcinomas.Aim:To review a series of 19 cytological preparations of metaplastic carcinomas to assess diagnostic cytological features.Methods:17 cases of fine-needle aspirates of histologically proven metaplastic carcinomas (4 monophasic spindle cell carcinomas, 4 squamous cell carcinomas and 11 biphasic tumours) were reviewed, with an emphasis on the presence of poorly differentiated carcinoma, squamous cell carcinoma, atypical spindle cells, benign stromal fragments and necrosis.Results:All cases were diagnosed as malignant, with 68% of cases showing moderate to high cellularity, and 47% showing necrosis. If the tumours were analysed according to the constituting components histologically, 7, 15 and 8 cases, respectively, possess poorly differentiated carcinoma cells, sarcomatoid malignant cells and squamous carcinoma cells, whereas these components were cytologically identified in 11, 10 and 7 cases, respectively. Dual tumour populations were identified in only 5 of the 11 biphasic carcinomas in the cytological preparations; and the stromal material was cytologically identified in the only case with chondroid stroma.Conclusions:Identification of metaplastic carcinoma in cytology remains problematic. There seems to be morphological overlap between various components. The identification of dual components, unequivocal squamous carcinoma cells and chondroid stroma is helpful for diagnosis, but it is uncommon. The presence of poorly differentiated carcinoma cells with a suggestion of focal spindle morphology is another clue to the suggestion of metaplastic carcinoma.
The impact of late career job loss on myocardial infarction and stroke: a 10 year follow up using the health and retirement survey
Authors: Gallo W T , Teng H M , Falba T A , Kasl S V , Krumholz H M , Bradley E H 
Published: June 2006

Background:Involuntary job loss is a major life event associated with social, economic, behavioural, and health outcomes, for which older workers are at elevated risk.Objective:To assess the 10 year risk of myocardial infarction (MI) and stroke associated with involuntary job loss among workers over 50 years of age.Methods:Analysing data from the nationally representative US Health and Retirement Survey (HRS), Cox proportional hazards analysis was used to estimate whether workers who suffered involuntary job loss were at higher risk for subsequent MI and stroke than individuals who continued to work. The sample included 4301 individuals who were employed at the 1992 study baseline.Results:Over the 10 year study frame, 582 individuals (13.5% of the sample) experienced involuntary job loss. After controlling for established predictors of the outcomes, displaced workers had a more than twofold increase in the risk of subsequent MI (hazard ratio (HR) = 2.48; 95% confidence interval (CI) = 1.49 to 4.14) and stroke (HR = 2.43; 95% CI = 1.18 to 4.98) relative to working persons.Conclusion:Results suggest that the true costs of late career unemployment exceed financial deprivation, and include substantial health consequences. Physicians who treat individuals who lose jobs as they near retirement should consider the loss of employment a potential risk factor for adverse vascular health changes. Policy makers and programme planners should also be aware of the risks of job loss, so that programmatic interventions can be designed and implemented to ease the multiple burdens of joblessness.
A Demonstration That Large-Scale Warming Is Not Urban
Authors: Parker David E. 
Published: June 2006

Abstract
On the premise that urban heat islands are strongest in calm conditions but are largely absent in windy weather, daily minimum and maximum air temperatures for the period 1950–2000 at a worldwide selection of land stations are analyzed separately for windy and calm conditions, and the global and regional trends are compared. The trends in temperature are almost unaffected by this subsampling, indicating that urban development and other local or instrumental influences have contributed little overall to the observed warming trends. The trends of temperature averaged over the selected land stations worldwide are in close agreement with published trends based on much more complete networks, indicating that the smaller selection used here is sufficient for reliable sampling of global trends as well as interannual variations. A small tendency for windy days to have warmed more than other days in winter over Eurasia is the opposite of that expected from urbanization and is likely to be a consequence of atmospheric circulation changes.
Understanding the Mid-Holocene Climate
Authors: Shin Sang-Ik , Sardeshmukh Prashant D. , Webb Robert S. , Oglesby Robert J. , Barsugli Joseph J. 
Published: June 2006

Abstract
Paleoclimatic evidence suggests that during the mid-Holocene epoch (about 6000 yr ago) North America and North Africa were significantly drier and wetter, respectively, than at present. Modeling efforts to attribute these differences to changes in orbital parameters and greenhouse gas (GHG) levels have had limited success, especially over North America. In this study, the importance of a possibly cooler tropical Pacific Ocean during the epoch (akin to a permanent La Niña–like perturbation to the present climate) in causing these differences is emphasized. Systematic sets of atmospheric general circulation model experiments, with prescribed sea surface temperatures (SSTs) in the tropical Pacific basin and an interactive mixed layer ocean elsewhere, are performed. Given the inadequacies of current fully coupled climate models in simulating the tropical Pacific climate, this intermediate coupling model configuration is argued to be more suitable for quantifying the contributions of the altered orbital forcing, GHG levels, and tropical Pacific SST conditions to the different mid-Holocene climates. The simulated responses in this configuration are in fact generally more consistent with the available evidence from paleovegetation and sedimentary records.
Coupling to the mixed layer ocean enhances the wind–evaporation–SST feedback over the tropical Atlantic Ocean. The net response to the orbital changes is to shift the North Atlantic intertropical convergence zone (ITCZ) northward, and make North Africa wetter. The response to the reduced GHG levels opposes, but does not eliminate, these changes. The northward-shifted ITCZ also blocks the moisture supply from the Gulf of Mexico into North America. This drying tendency is greatly amplified by the local response to La Niña–like conditions in the tropical Pacific. Consistent with the paleoclimatic evidence, the simulated North American drying is also most pronounced in the growing (spring) season.
The Termination of the 1997–98 El Niño. Part I: Mechanisms of Oceanic Change*
Authors: Vecchi Gabriel A. , Harrison D. E. 
Published: June 2006

AbstractThe 1997–98 El Niño was both unusually strong and terminated unusually. Warm eastern equatorial Pacific (EEqP) sea surface temperature anomalies (SSTAs) exceeded 4°C at the event peak and lasted well into boreal spring of 1998, even though subsurface temperatures began cooling in December 1997. The oceanic processes that controlled this unusual termination are explored here and can be characterized by three features: (i) eastward propagating equatorial Pacific thermocline (Ztc) shoaling beginning in the central Pacific in November 1997; (ii) persistent warm EEqP SSTA between December 1997 and May 1998, despite strong EEqP Ztc shoaling (and subsurface cooling); and (iii) an abrupt cooling of EEqP SSTA in early May 1998 that exceeded 4°C within two weeks.It is shown here that these changes can be understood in terms of the oceanic response to changes to the meridional structure of the near-equatorial zonal wind field. Equatorial near-date-line westerly wind anomalies greatly decreased in late 1997, associated with a southward shift of convective and wind anomalies. In the EEqP, equatorial easterlies disappeared (reappeared) in late January (early May) 1998, driving the springtime extension (abrupt termination) of this El Niño event. The authors suggest that the wind changes arise from fundamentally meridional processes and are tied to the annual cycle of insolation.
Spatiotemporal Disaggregation of Remotely Sensed Precipitation for Ensemble Hydrologic Modeling and Data Assimilation
Authors: Margulis Steven A. , Entekhabi Dara , McLaughlin Dennis 
Published: June 2006

Abstract
Historically, estimates of precipitation for hydrologic applications have largely been obtained using ground-based rain gauges despite the fact that they can contain significant measurement and sampling errors. Remotely sensed precipitation products provide the ability to overcome spatial coverage limitations, but the direct use of these products generally suffers from their relatively coarse spatial and temporal resolution and inherent retrieval errors. A simple ensemble-based disaggregation scheme is proposed as a general framework for using remotely sensed precipitation data in hydrologic applications. The scheme generates fine-scale precipitation realizations that are conditioned on large-scale precipitation measurements. The ensemble approach allows for uncertainty related to the complex error characteristics of the remotely sensed precipitation (undetected events, nonzero false alarm rate, etc.) to be taken into account. The methodology is applied through several synthetic experiments over the southern Great Plains using the Global Precipitation Climatology Project 1° daily (GPCP-1DD) product. The scheme is shown to reasonably capture the land-surface-forcing variability and propagate this uncertainty to the estimation of soil moisture and land surface flux fields at fine scales. The ensemble results outperform a case using sparse ground-based forcing. Additionally, the ensemble nature of the framework allows for simply merging the open-loop soil moisture estimation scheme with modern data assimilation techniques like the ensemble Kalman filter. Results show that estimation of the soil moisture and surface flux fields are further improved through the assimilation of coarse-scale microwave radiobrightness observations.
Reconciling Simulated Moisture Fluxes Resulting from Alternate Hydrologic Model Time Steps and Energy Budget Closure Assumptions
Authors: Haddeland Ingjerd , Lettenmaier Dennis P. , Skaugen Thomas 
Published: June 2006

Abstract
Hydrological model predictions are sensitive to model forcings, input parameters, and the parameterizations of physical processes. Analyses performed for the Variable Infiltration Capacity model show that the resulting moisture fluxes are sensitive to the time step and energy balance closure assumptions. In addition, the model results are sensitive to the method of spatial and temporal disaggregation of precipitation. For parameter estimation purposes, it is desirable to do parameter searches in water balance mode (meaning that the effective surface temperature is assumed equal to the surface air temperature; hence no iteration for energy balance closure is performed) at daily time steps. However, transferring these parameters directly to other model modes (e.g., energy balance, in which an iteration for effective surface temperature is performed, and/or different model time steps) results in changes in the simulated moisture fluxes. The simulated differences in moisture fluxes are mainly a result of the parameterization of evapotranspiration at different time steps and model modes. A simple scheme that calculates correction factors for some model parameters is developed. The scheme is used to match simulated moisture fluxes in hourly and 3-hourly energy balance mode to the daily water balance simulation results, and to match hourly energy balance runs using spatially and temporally disaggregated precipitation to 3-hourly energy balance runs using uniformly disaggregated precipitation. For both approaches, the corrected simulations match the baseline simulations quite closely, both over transects across much of the continental United States and for test applications in the Ohio and Arkansas–Red River basins.
SPODOBASE : an EST database for the lepidopteran crop pest Spodoptera
Authors: Nègre Vincent , Hôtelier Thierry , Volkoff Anne-Nathalie , Gimenez Sylvie , Cousserans François , Mita Kazuei , Sabau Xavier , Rocher Janick , López-Ferber Miguel , d'Alençon Emmanuelle , Audant Pascaline , Sabourault Cécile , Bidegainberry Vincent , Hilliou Frédérique , Fournier Philippe 
Published: June 2006

Abstract

Background
The Lepidoptera Spodoptera frugiperda is a pest which causes widespread economic damage on a variety of crop plants. It is also well known through its famous Sf9 cell line which is used for numerous heterologous protein productions. Species of the Spodoptera genus are used as model for pesticide resistance and to study virus host interactions. A genomic approach is now a critical step for further new developments in biology and pathology of these insects, and the results of ESTs sequencing efforts need to be structured into databases providing an integrated set of tools and informations.

Description
The ESTs from five independent cDNA libraries, prepared from three different S. frugiperda tissues (hemocytes, midgut and fat body) and from the Sf9 cell line, are deposited in the database. These tissues were chosen because of their importance in biological processes such as immune response, development and plant/insect interaction. So far, the SPODOBASE contains 29,325 ESTs, which are cleaned and clustered into non-redundant sets (2294 clusters and 6103 singletons). The SPODOBASE is constructed in such a way that other ESTs from S. frugiperda or other species may be added. User can retrieve information using text searches, pre-formatted queries, query assistant or blast searches. Annotation is provided against NCBI, UNIPROT or Bombyx mori ESTs databases, and with GO-Slim vocabulary.

Conclusion
The SPODOBASE database provides integrated access to expressed sequence tags (EST) from the lepidopteran insect Spodoptera frugiperda. It is a publicly available structured database with insect pest sequences which will allow identification of a number of genes and comprehensive cloning of gene families of interest for scientific community. SPODOBASE is available from URL: http://bioweb.ensam.inra.fr/spodobase
Effect of high up front charges on access to surgery for poor patients at a public hospital in New Mexico
Authors: Kaufman Will , Chavez Augustine S , Skipper Betty , Kaufman Arthur 
Published: June 2006

Abstract

Background
A public hospital in New Mexico required collection of 50% of estimated costs prior to elective surgeries for self-pay patients. This study assesses the impact of this policy on access to elective surgical procedures.

Methods
Chi-square tests determined if there was a statistically significant difference between the number of self-pay and insured patient cancellations for financial reasons. A multivariate binomial regression model was used to calculate risk ratios and confidence limits for effects of race/ethnicity, and insurance status, controlling for gender, on these cancellations.

Results
Of the 667 cancellations, there were 99 self-pay and 568 insured patients. Cancellations for financial reasons occurred in 55.6% of self-pay and 9.3% of insured patients (p < 0.0001). Inability to pay 50% up front accounted for 76.4% of self-pay patient cancellations for financial reasons. Self-pay, non-Hispanic whites and minority race/ethnicities were 8.76 and 8.61 times more likely to cancel for financial reasons, respectively, than insured non-Hispanic whites.

Conclusion
Self-pay patients, regardless of race/ethnicity, have elective surgical procedures cancelled for financial reasons significantly more often than insured patients. The hospital's 50% up-front payment policy represents a significant financial barrier to accessing elective surgical procedures for self-pay patients.
Prevention of disease progression in a patient with a gastric cancer-re-recurrence. Outcome after intravenous treatment with the novel antineoplastic agent taurolidine. Report of a case
Authors: Braumann Chris , Winkler Goetz , Rogalla Patrick , Menenakos Charalambos , Jacobi Christoph A 
Published: June 2006

Abstract

Background
Taurolidine (TRD) is a novel agent with multimodal antineoplastic effects. We present the case of a tumor remission after intravenous administration of taurolidine in a patient with gastric cancer re-recurrence.

Case presentation
A 58 years old male patient suffering from a gastric adenocarcinoma was submitted to partial gastrectomy and partial liver resection (pT2, pN1, pM1L (liver segment 2), N0, V0). 24 months later a local recurrence was diagnosed and the patient was reoperated. Postoperatively the patient underwent a palliative chemotherapy with eloxatin, FU, and leucovorin. A subsequent CT-revealed a liver metastasis and a recurrence adjacent to the hepatic artery. After successful radiofrequency ablation of the liver metastasis the patient was intravenously treated with 2% taurolidine. The patient endured the therapy well and no toxicity was observed. CT-scans revealed a stable disease without a tumor progression or metastatic spread. After 39 cycles the patient was submitted to left nephrectomy due to primary urothelial carcinoma and died 2 days later due to myocardial infarction. Postmortem histology of the esophageal-jejunal anastomosis and liver revealed complete remission of the known metastasized gastric adenocarcinoma.

Conclusion
The intravenous treatment with 2% taurolidine led to a histological remission of the tumor growth without any toxicity for the patient.
Pivotal Advance: Activation of cell surface Toll-like receptors causes shedding of the hemoglobin scavenger receptor CD163
Authors: Weaver Lehn K , Hintz-Goldstein Katharine A , Pioli Patricia A , Wardwell Kathleen , Qureshi Nilofer , Vogel Stefanie N , Guyre Paul M 
Published: June 2006

Abstract
The hemoglobin scavenger receptor (HbSR) CD163 is a monocyte/macrophage-specific glycoprotein that binds and facilitates uptake of haptoglobin-hemoglobin (Hp-Hb) complexes, which are rapidly formed in the circulation upon hemolysis of red blood cells. Hemolysis can be caused by a diverse range of infectious agents and provides pathogens a source of iron to enhance their survival and replication. Previous work demonstrated that lipopolysaccharide (LPS) activates monocytes to cleave cell-bound HbSR into a soluble mediator that retains the capacity to bind Hp-Hb complexes. We report that blocking LPS activation of Toll-like receptor 4 prevents LPS-mediated shedding of CD163. Furthermore, activation of two other cell surface Toll-like receptors (TLR), TLR2 and TLR5, induces shedding of the HbSR from human monocytes. In contrast, treatment of monocytes with intracellular TLR3, TLR7, and TLR9 agonists failed to cause HbSR shedding, suggesting that this shedding event is selective to cell surface TLR activation. These data demonstrate that the soluble HbSR is released from monocytic cells in response to TLR signaling as an acute innate immune response to extracellular pathogen infections.