bluuebunny/crossref_metadata_2025_split huggingface dataset:
Scanning efficacy of p-Chips implanted in the wing and leg of the Big Brown Bat (Eptesicus fuscus)
Authors: Seheult Shane D I , Panchal Raj , Borisenko Alex V , Bennett Patrick J , Faure Paul A 
Published: April 2024

Abstract
Individual marking techniques are critical for studying animals, especially in the wild. Current marking methods for bats (Order Chiroptera) have practical limitations and some can cause morbidity. We tested the p-Chip (p-Chip Corp.)—a miniaturized, laser light-activated microtransponder—as a prospective marking technique in a captive research colony of Big Brown Bats (Eptesicus fuscus). We assessed long-term readability and postimplantation effects of p-Chips injected subcutaneously above the second metacarpal (wing; n = 30) and the tibia (leg; n = 13 in both locations). Following implantation (Day 0), p-Chips were scanned with a hand-held ID reader (wand) on postimplantation days (PIDs) 1, 8, 15, 22, 32, 60, 74, 81, 88, 95, and over 1 year later (PID 464). For each trial, we recorded: (1) animal handling time; (2) scan time; (3) number of wand flashes; (4) p-Chip visibility; and (5) overall condition of the bat. Average scan times for p-Chips implanted in both the wing and leg increased over the duration of the study; however, the number of wand flashes decreased, suggesting that efficacy of p-Chip recording increased with user experience. Importantly, over 464 days both the visibility and readability of p-Chips in the wing remained high and superior to tags in the leg, establishing the second metacarpal as the preferred implantation site. Observed morbidity and mortality in captive bats with p-Chips was similar to baseline values for bats without these tags. Because scan efficiency on PID 464 was comparable with earlier days, this indicates that p-Chips implanted in the wing may be suitable as a long-term marking method. Our provisional results suggest that p-Chips are viable for extended field testing to see if they are suitable as an effective alternative to traditional methods to mark bats.
First record of a structural infestation by the bird flea Dasypsyllus gallinulae perpinnatus (Siphonaptera: Ceratophyllidae) in the San Francisco Bay Area, California, USA
Authors: Roth Tara , Crews Arielle 
Published: April 2024

Abstract
Herein we present the first-known case report of a structural infestation by the bird flea (Dasypsyllus gallinulae perpinnatus) (Dale 1878) in the United States. In March of 2023, the San Mateo County Mosquito and Vector Control District was contacted by a resident in South San Francisco, CA who reported the presence of fleas inside their condominium. The resident had 2 dogs who were on oral flea medication and only 1 inhabitant out of 4 reported receiving flea bites. The front walkway, backyard, and garage were flagged and a small passerine nest was removed from a fire alarm bell in the front walkway. A total of 31 fleas (13 males, 18 females) were collected by flagging from the front entryway underneath the nest. One female flea was collected from the backyard, and 20 (9 males, 11 females) were collected by the resident from inside the house. A total of 387 fleas (163 males, 224 females) were collected from the nest of a small passerine. All life stages (egg, larvae, pupae, and adult) were observed within the nest. Additional parasites in the nest included bird lice and larval western black-legged ticks (Ixodes pacificus, Cooley and Kohls 1943). Research should be conducted into whether bird fleas are capable of transmitting avian pathogens to humans and this information should be communicated to healthcare providers as part of a One Health approach. Additionally, resources to aid in species-level flea identification should be made accessible to pest control operators as this will aid the development of targeted treatments as part of an integrated pest management plan.
Bayesian model selection via mean-field variational approximation
Authors: Zhang Yangfan , Yang Yun 
Published: April 2024

Abstract
This article considers Bayesian model selection via mean-field (MF) variational approximation. Towards this goal, we study the non-asymptotic properties of MF inference that allows latent variables and model misspecification. Concretely, we show a Bernstein–von Mises (BvM) theorem for the variational distribution from MF under possible model misspecification, which implies the distributional convergence of MF variational approximation to a normal distribution centring at the maximal likelihood estimator. Motivated by the BvM theorem, we propose a model selection criterion using the evidence lower bound (ELBO), and demonstrate that the model selected by ELBO tends to asymptotically agree with the one selected by the commonly used Bayesian information criterion (BIC) as the sample size tends to infinity. Compared to BIC, ELBO tends to incur smaller approximation error to the log-marginal likelihood (a.k.a. model evidence) due to a better dimension dependence and full incorporation of the prior information. Moreover, we show the geometric convergence of the coordinate ascent variational inference algorithm, which provides a practical guidance on how many iterations one typically needs to run when approximating the ELBO. These findings demonstrate that variational inference is capable of providing a computationally efficient alternative to conventional approaches in tasks beyond obtaining point estimates.
Deciphering molecular events behind Systemin-induced resistance to Botrytis cinerea in tomato plants
Authors: Pastor-Fernández Julia , Sanmartín Neus , Manresa-Grao Maria , Cassan Cédric , Pétriacq Pierre , Gibon Yves , Gamir Jordi , Romero-Rodriguez Beatriz , Castillo Araceli G , Cerezo Miguel , Flors Victor , Sánchez-Bel Paloma 
Published: April 2024

Abstract
Plant defence peptides are paramount endogenous danger signals secreted after a challenge, intensifying the plant immune response. The peptidic hormone Systemin (Sys) was shown to participate in resistance in several plant pathosystems, although the mechanisms behind Sys-induced resistance when exogenously applied remain elusive. We performed proteomic, metabolomic, and enzymatic studies to decipher the Sys-induced changes in tomato plants in either the absence or the presence of Botrytis cinerea infection. Sys treatments triggered direct proteomic rearrangement mostly involved in carbon metabolism and photosynthesis. However, the final induction of defence proteins required concurrent challenge, triggering priming of pathogen-targeted proteins. Conversely, at the metabolomic level, Sys-treated plants showed an alternative behaviour following a general priming profile. Of the primed metabolites, the flavonoids rutin and isorhamnetin and two alkaloids correlated with the proteins 4-coumarate-CoA-ligase and chalcone-flavanone-isomerase triggered by Sys treatment. In addition, proteomic and enzymatic analyses revealed that Sys conditioned the primary metabolism towards the production of available sugars that could be fuelling the priming of callose deposition in Sys-treated plants; furthermore, PR1 appeared as a key element in Sys-induced resistance. Collectively, the direct induction of proteins and priming of specific secondary metabolites in Sys-treated plants indicated that post-translational protein regulation is an additional component of priming against necrotrophic fungi.
When you think you should transfuse…don’t!
Authors: Gammon Richard R , Alvarez Harold , Masias Camila , Benitez Nancy , Resto Claribel 
Published: April 2024

Abstract
A 48-year-old female presented to the emergency department with severe fatigue. Admission laboratory test results were hemoglobin 6.6 g/dL, platelet count 287,000/μL, and white blood cell count 25,200/μL. Lactate dehydrogenase was elevated at 898 U/L, haptoglobin was markedly decreased (&lt; 31 mg/dL), indirect bilirubin was elevated (5.3 mg/dL), and the absolute reticulocyte count was low at 0.0050/μL. A sample was sent to the immunohematology reference laboratory. The direct antiglobulin test immunoglobulin G was negative; C3 was 1+. All cells were reactive at immediate spin phase, indirect antiglobulin testing (IAT) with polyethylene glycol, with low ionic strength saline, neat, prewarm, and in the solid phase. All cells were nonreactive at IAT-ficin. Additional testing included a cold antibody titer that was 1:4096 and thermal amplitude studies demonstrating reactivity of 2+ at 37°C. These results were consistent with a clinically significant anti-Pr and cold agglutinin disease (CAD). Although rituximab is effective in autoimmune hemolytic anemia, this may take weeks. The patient was treated with pegcetacoplan, a pegylated peptide that targets C3 inhibiting hemolysis. The patient was discharged on day 29 with a hemoglobin of 8 g/dL. This is a report of one of the first patients successfully treated with pegcetacoplan for CAD.
Uncommon pathogen misidentification of Herbaspirillum huttiense as Burkholderia cepacia in bacteremia: a case report
Authors: Wang Qun , Cai Xinjian , Zhang Li 
Published: April 2024

Abstract
Herbaspirillum huttiense is an opportunistic pathogen associated with rare cases of bacteremia. In this case report, H huttiense was isolated from blood samples collected from an intravenous catheter (incubated for 20.8 hours) and a peripheral vein (incubated for 14.16 hours) of a lung adenocarcinoma patient. Positive blood culture bottles were subjected to smear preparation, and Gram staining and microscopic examination revealed the presence of gram-negative rods in both aerobic bottles. We used the VITEK MS automatic microbial mass spectrometry system, VITEK 2 Compact automatic microbial analysis system, and high-throughput nucleic acid sequencing for accurate identification of the isolate. It is noteworthy that although the VITEK 2 Compact identified the isolate as Burkholderia cepacia, confirmation through VITEK MS mass spectrometry and 16S ribosomal DNA (rDNA) sequencing identified it as H huttiense. Subsequently, antimicrobial susceptibility testing was performed using the broth microdilution method, following the guidelines for nonfermenting gram-negative bacilli provided by the Clinical and Laboratory Standards Institute. This case highlights the possibility of misidentification of H huttiense as B cepacia by VITEK 2 Compact in certain situations, emphasizing the importance of considering uncommon pathogens, such as H huttiense, in the context of bacteremia in cancer patients.
Interferons dominate damage and activity in juvenile scleroderma
Authors: Kose Hulya , Simsek Abdurrahman , Kizmaz Muhammed Ali , Bozkurt Tugce , Ozturk Ferdi , Cekic Sukru , Budak Ferah , Sarıcaoglu Hayriye , Kilic Sara Sebnem 
Published: April 2024

ABSTRACT

Objectives
Juvenile scleroderma is a heterogeneous group of diseases associated with sclerotic skin lesions, grouped as juvenile systemic sclerosis and juvenile localized scleroderma. This study aims to measure the cytokine and chemokine levels involved in interferon (IFN) signalling in patients with juvenile scleroderma and determine their correlation with disease severity.

Methods
Twenty-nine juvenile localized scleroderma, five juvenile systemic sclerosis, and nine healthy controls were included in the study. Cytokines and chemokines involved in IFN gene signalling (IL-1, IL-6, IL-8, IP-10, MCP1, TNF-α, CXCL-11, IFN-α, IFN-β, IFN-γ) and IFN-stimulated genes (ISGs), including IFI27, IFI44, ISIG15, IFIT1, OAS1, RSAD2, were measured by ELISA and RT-PCR method, respectively.

Results
A significant increase in IFN-α, IFN-β, IFN-γ, TNF-α, IL-1, IL-6 IL-8, IP-10, and MCP1 levels was observed in patients with juvenile systemic sclerosis compared with the healthy control group. Furthermore, IFN-α and IP-10 were elevated in both juvenile localized scleroderma and juvenile systemic sclerosis compared to the healthy control group. IFN-γ and IFN-α positively correlated with LoSAI and LoSDI levels, respectively. According to PGA-A analysis, IFN-β, IFN-γ, TNF-α, IL-8, IP10, MCP1, and CXCL11 were significantly higher in active disease than in the inactive state in both groups.

Conclusion
The results suggest that IFN signalling may be impaired in patients with juvenile scleroderma. Significant changes were observed in cytokines and genes related to IFN signalling, which may have a crucial role in monitoring disease activity. In addition, we have gained important insights into the possibility of using IFN-α and IFN-γ as biomarkers for monitoring juvenile scleroderma activity and damage.
Predictors of disease course in systemic juvenile idiopathic arthritis
Authors: Kaplan Melike Mehveş , Ekici Tekin Zahide , Çelikel Elif , Güngörer Vildan , Karagöl Cüneyt , Öner Nimet , Polat Merve Cansu , Öztürk Didem , Özçelik Emine , Işıklar Ekici Mehveş , Çelikel Acar Banu 
Published: April 2024

ABSTRACT

Objectives
The aim of this study was to identify potential predictors of the disease course of systemic juvenile idiopathic arthritis (sJIA) at the time of diagnosis.

Methods
This retrospective observational study was conducted in patients diagnosed with sJIA in our hospital between April 2009 and October 2023. The relationship between the disease course of sJIA patients and demographic, clinical, laboratory findings and complications was analysed.

Results
Of the 51 patients diagnosed with sJIA, 26 (51%) patients had monocyclic, 7 (13.7%) polycyclic, and 18 (35.2%) persistent disease course. The presence of arthritis, polyarticular involvement, and hip involvement at the time of diagnosis were associated with persistent disease course (P = .009, P = .003, P = .003). Serositis and higher white blood cell and neutrophil counts at the time of diagnosis were associated with a monocyclic disease course (P = .034, .002, .008). However, no significant correlation was found between macrophage activation syndrome and disease course (P = 1).

Conclusions
sJIA patients with polyarthritis and hip involvement at disease onset may develop a persistent course. Although macrophage activation syndrome is an important complication of sJIA, its effect on the course of the disease was not found in this study.
Secondary cerebro-cerebellar and intra-cerebellar dysfunction in cerebellar mutism syndrome
Authors: McAfee Samuel S , Robinson Giles , Gajjar Amar , Phillips Nicholas S , Zhang Silu , Zou Stinnett Ping , Sitaram Ranganatha , Raches Darcy , Conklin Heather M , Khan Raja B , Scoggins Matthew A 
Published: April 2024

Abstract

Background
Cerebellar mutism syndrome (CMS) is characterized by deficits of speech, movement, and affect that can occur following tumor removal from the posterior fossa. The role of cerebro-cerebellar tract injuries in the etiology of CMS remains unclear, with recent studies suggesting that cerebro-cerebellar dysfunction may be related to chronic, rather than transient, symptomatology.

Methods
We measured functional connectivity between the cerebellar cortex and functional nodes throughout the brain using fMRI acquired after tumor removal but prior to adjuvant therapy in a cohort of 70 patients diagnosed with medulloblastoma. Surgical lesions were mapped to the infratentorial anatomy, and connectivity with cerebral cortex was tested for statistical dependence on extent of cerebellar outflow pathway injury.

Results
CMS diagnosis was associated with an increase in connectivity between the right cerebellar and left cerebral hemisphere, maximally between cerebellum and ventromedial prefrontal cortex (VM-PFC). Connectivity dependence on cerebellar outflow was significant for some speech nodes but not for VM-PFC, suggesting altered input to the cerebellum. Connectivity between posterior regions of cerebellar cortex and ipsilateral dentate nuclei was abnormal in CMS participants, maximally within the right cerebellar hemisphere.

Conclusions
The functional abnormalities we identified are notably upstream of where causal surgical injury is thought to occur, indicating a secondary phenomenon. The VM-PFC is involved in several functions that may be relevant to the symptomatology of CMS, including emotional control and motor learning. We hypothesize that these abnormalities may reflect maladaptive learning within the cerebellum consequent to disordered motor and limbic function by the periaqueductal gray and other critical midbrain targets.
The Domain of the Right? Explaining National Parliamentary Preferences on EU-Related Self-Empowerment
Authors: Borońska-Hryniewiecka Karolina , Sacriste Guillaume 
Published: April 2024

Abstract
In the academic debate about the deficits of representative democracy in the European Union, the views of members of parliaments about their EU-oriented roles remain largely unknown. Against this background, we exploit a novel dataset from an author-designed survey conducted in seven national parliaments to unravel MPs’ preferences with regard to their EU-oriented empowerment. Our findings allow us to identify the dominant cognitive schemas mobilised among parliamentarians which attribute particular legitimacy-related meanings to proposed institutional reforms. They point to a stronger explanatory power of party ideological position over national constitutional orientations, with right-wing parties being more supportive towards parliamentary empowerment than their centre and centre-left counterparts, and mainstream parties being more sceptical of it than radical groups on both sides of the spectrum.
Direct and indirect responses of the Arabidopsis transcriptome to an induced increase in trehalose 6-phosphate
Authors: Avidan Omri , Martins Marina C M , Feil Regina , Lohse Marc , Giorgi Federico M , Schlereth Armin , Lunn John E , Stitt Mark 
Published: April 2024

Abstract
Trehalose 6-phosphate (Tre6P) is an essential signal metabolite that regulates the level of sucrose, linking growth and development to the metabolic status. We hypothesized that Tre6P plays a role in mediating the regulation of gene expression by sucrose. To test this, we performed transcriptomic profiling on Arabidopsis (Arabidopsis thaliana) plants that expressed a bacterial TREHALOSE 6-PHOSPHATE SYNTHASE (TPS) under the control of an ethanol-inducible promoter. Induction led to a 4-fold rise in Tre6P levels, a concomitant decrease in sucrose, significant changes (FDR ≤ 0.05) of over 13,000 transcripts, and 2-fold or larger changes of over 5,000 transcripts. Comparison with nine published responses to sugar availability allowed some of these changes to be linked to the rise in Tre6P, while others were probably due to lower sucrose or other indirect effects. Changes linked to Tre6P included repression of photosynthesis-related gene expression and induction of many growth-related processes including ribosome biogenesis. About 500 starvation-related genes are known to be induced by SUCROSE-NON-FERMENTING-1-RELATED KINASE 1 (SnRK1). They were largely repressed by Tre6P in a manner consistent with SnRK1 inhibition by Tre6P. SnRK1 also represses many genes that are involved in biosynthesis and growth. These responded to Tre6P in a more complex manner, pointing toward Tre6P interacting with other C-signaling pathways. Additionally, elevated Tre6P modified the expression of genes encoding regulatory subunits of the SnRK1 complex and TPS class II and FCS-LIKE ZINC FINGER proteins that are thought to modulate SnRK1 function and genes involved in circadian, TARGET OF RAPAMYCIN, light, abscisic acid, and other hormone signaling.
Intimate partner homicide: Risk constellations in separation conflicts and points of intervention for the police
Authors: Horn Stefanie , Vogt Catharina , Wüller Chiara , Görgen Thomas 
Published: April 2024

Abstract
The escalation of conflicts in intimate relationships to potentially fatal partner violence poses a massive safety risk for victims involved. In addition, separations represent a particularly vulnerable phase for the dynamics of violent escalation. Based on an analysis of court records of three cases of attempted or completed homicides in the course of intimate partner separation in Germany, we outline the conditions under which the separation process is to be assessed by the police as a high-risk phase for the escalation of violence. The study's findings suggest that police work would be more effective if measures were implemented to focus on the overall history of violence rather than on isolated cases, and if these measures were aimed directly at the perpetrators. Moreover, inter-institutional cooperation would support the police in identifying perpetrators at an early stage and carrying out valid risk assessments, rather than working in isolation. The study presents starting points and options for police prevention measures.
Examining the relationship between officer attitudes and behaviour in a multi-site trial of procedural justice training
Authors: Telep Cody W , Weisburd David , Jonathan-Zamir Tal , Zastrow Taryn 
Published: April 2024

Abstract
While reformers view police training as an important means for improving performance, the training evidence base has historically been weak. Little research has focussed on how training impacts both attitudes and behaviour in the field, and the extent to which changes in attitudes following a training program are linked to officer behaviour in the field. This paper uses data from a multi-site randomized trial of procedural justice training in hot spots to assess the attitude–behaviour link. We ask to what extent do officers’ attitudes about procedural justice impact their behaviour in the field? We find no support for officer baseline attitudes being predictive of their use of procedural justice with the public. But for trained officers, we do find evidence that attitudes following training are related to behaviour in observed interactions in the field. We conclude with a discussion of the implications for police training and training evaluation studies.
The irrational failure to act
Authors: Heeney Matthew 
Published: April 2024

Abstract
I defend against a salient objection the thesis that practical rationality requires us to perform intentional actions. The objection is that if rationality requires the performance of intentional actions, then agents are irrational for failing to succeed in what they intend to do. I reply to this objection by hewing closely to the principle that the rational ‘ought’ implies ‘can’. We are rationally required not to successfully realize the content of our intentions but to exercise the fallible abilities in our possession. Taking this line permits us to agree that we are not irrational for failing to succeed, while also endorsing the anti-Internalist claim that practical rationality embraces intentional actions themselves, rather than merely the beliefs and intentions that prompt and sustain them.