bluuebunny/crossref_metadata_2025_split huggingface dataset:
Critical period of oxygen supplementation and invasive ventilation: implications for severe retinopathy of prematurity
Authors: Choi Ho Jung , Shin Baek Sup , Shin Seung Han , Kim Ee-Kyung , Kim Han-Suk 
Published: April 2024

Abstract
Background
Several studies have identified graded oxygen saturation targets to prevent retinopathy of prematurity (ROP), a serious complication in preterm infants. We aimed to analyze the critical period of oxygen supplementation and/or invasive ventilation associated with severe ROP.

Methods
This retrospective case-control study included neonates with a gestational age (GA) < 29 weeks. Participants were divided into two groups: treated retinopathy and untreated/no retinopathy. Time-weighted average FiO2 (TWAFiO2) and weekly invasive ventilation were compared between groups by postnatal age (PNA) and postmenstrual age (PMA). The association of treated retinopathy with TWAFiO2 and invasive ventilation was analyzed.

Results
Data from 287 neonates were analyzed; 98 were treated for ROP and had lower GAs (25.5 vs. 27.4 weeks, p < 0.01) and lower birthweights (747.6 vs. 1014 g, p < 0.001) than those with untreated/no ROP. TWAFiO2 was higher from PMA 26–34 weeks, except for PMA 31 weeks in treated ROP, and higher in the first nine weeks of life in treated ROP. On multiple logistic regression, TWAFiO2 and invasive ventilation were associated with ROP treatment during the first seven weeks PNA. Invasive ventilation was associated with ROP treatment from PMA 26–31 weeks; no association was found for TWAFiO2 and PMA.

Conclusions
Amount of oxygen supplementation and/or invasive ventilation during the first 7 weeks of life or up to 31 weeks PMA was associated with development of severe ROP. This period might be candidate timing for strict oxygen supplementation strategies in preterm infants, while concerns of mortality with low oxygen supplementation should be further explored.
Hereditary or acquired? Comprehensive genetic testing assists in stratifying angioedema patients
Authors: Rozevska Marija , Kanepa Adine , Purina Signe , Gailite Linda , Nartisa Inga , Farkas Henriette , Rots Dmitrijs , Kurjane Natalja 
Published: March 2024

AbstractHereditary angioedema (HAE) poses diagnostic challenges due to its episodic, non-specific symptoms and overlapping conditions. This study focuses on the genetic basis of HAE, particularly focusing on unresolved cases and those with normal C1-inhibitor levels (nC1-INH HAE). This study reveals that conventional testing identified pathogenic variants in only 10 patients (n = 32), emphasizing the necessity for an integrative approach using genome, exome, and transcriptome sequencing. Despite extensive genetic analyses, the diagnostic yield for nC1-INH HAE remains low in our study, the pathogenic variant for nC1-INH HAE was identified in only 1 patient (n = 21). Investigation into candidate genes yielded no pathogenic variants, prompting a re-evaluation of patients’ diagnoses. This study advocates for a nuanced approach to genetic testing, recognizing its limitations and emphasizing the need for continuous clinical assessment. The complex genetic landscape of nC1-INH HAE necessitates further research for a more comprehensive understanding. In conclusion, this study contributes valuable insights into the genetic intricacies of HAE, highlighting the challenges in diagnosis and the evolving nature of the disease. The findings underscore the importance of advanced sequencing techniques and an integrated diagnostic strategy in unravelling the complexities of HAE, particularly in nС1-INH HAE cases.
The role of goblet cells in Crohn’ s disease
Authors: Wang Zichen , Shen Jun 
Published: April 2024

AbstractThe prevalence of Crohn’s disease (CD), a subtype of inflammatory bowel disease (IBD), is increasing worldwide. The pathogenesis of CD is hypothesized to be related to environmental, genetic, immunological, and bacterial factors. Current studies have indicated that intestinal epithelial cells, including columnar, Paneth, M, tuft, and goblet cells dysfunctions, are strongly associated with these pathogenic factors. In particular, goblet cells dysfunctions have been shown to be related to CD pathogenesis by direct or indirect ways, according to the emerging studies. The mucus barrier was established with the help of mucins secreted by goblet cells. Not only do the mucins mediate the mucus barrier permeability and bacterium selection, but also, they are closely linked with the endothelial reticulum stress during the synthesis process. Goblet cells also play a vital role in immune response. It was indicated that goblet cells take part in the antigen presentation and cytokines secretion process. Disrupted goblet cells related immune process were widely discovered in CD patients. Meanwhile, dysbiosis of commensal and pathogenic microbiota can induce myriad immune responses through mucus and goblet cell-associated antigen passage. Microbiome dysbiosis lead to inflammatory reaction against pathogenic bacteria and abnormal tolerogenic response. All these three pathways, including the loss of mucus barrier function, abnormal immune reaction, and microbiome dysbiosis, may have independent or cooperative effect on the CD pathogenesis. However, many of the specific mechanisms underlying these pathways remain unclear. Based on the current understandings of goblet cell’s role in CD pathogenesis, substances including butyrate, PPARγagonist, Farnesoid X receptor agonist, nuclear factor-Kappa B, nitrate, cytokines mediators, dietary and nutrient therapies were all found to have potential therapeutic effects on CD by regulating the goblet cells mediated pathways. Several monoclonal antibodies already in use for the treatment of CD in the clinical settings were also found to have some goblet cells related therapeutic targets. In this review, we introduce the disease-related functions of goblet cells, their relationship with CD, their possible mechanisms, and current CD treatments targeting goblet cells.
Exploring pre-MRI imaging tests: patient survey reveals potential implications for healthcare efficiency in Israel
Authors: Kaim Arielle , Singer Clara , Bergovoy-Yellin Lucia , Luxenburg Osnat , Vaknin Sharona , Boldor Noga , Wilf-Miron Rachel , Myers Vicki 
Published: April 2024

Abstract
Background
Medical imaging tests are vital in healthcare but can be costly, impacting national health expenditures. Magnetic resonance imaging (MRI) is a crucial diagnostic tool for assessing medical conditions. However, the rising demand for MRI scans has frequently strained available resources. This study aimed to estimate the prevalence of different imaging tests in individuals who eventually had an MRI, in the Israeli public health system.

Methods
An online survey of patient experience of scheduling an MRI was conducted in January–February 2023, among 557 Israeli adults, representing all four health maintenance organizations (HMOs). All participants had undergone an MRI in the public health system within the past year.

Results
Results showed that 60% of participants underwent other imaging tests before their MRI scan. Of those, computed tomography (CT) scans (43%), X-rays (39%), and ultrasounds (32%) were the most common additional imaging procedures. In addition, of the 60% of participants, 23% had undergone more than one prior imaging examination.

Conclusions
These findings highlight the high prevalence of preliminary imaging tests prior to MRI, with many patients undergoing multiple tests for the same problem. The health system may need to evaluate whether current clinical guidelines defining the use of various imaging tests are cost-effective.
Capillary refill time response to a fluid challenge or a vasopressor test: an observational, proof-of-concept study
Authors: Hernández Glenn , Valenzuela Emilio Daniel , Kattan Eduardo , Castro Ricardo , Guzmán Camila , Kraemer Alicia Elzo , Sarzosa Nicolás , Alegría Leyla , Contreras Roberto , Oviedo Vanessa , Bravo Sebastián , Soto Dagoberto , Sáez Claudia , Ait-Oufella Hafid , Ospina-Tascón Gustavo , Bakker Jan 
Published: April 2024

Abstract
Background
Several studies have validated capillary refill time (CRT) as a marker of tissue hypoperfusion, and recent guidelines recommend CRT monitoring during septic shock resuscitation. Therefore, it is relevant to further explore its kinetics of response to short-term hemodynamic interventions with fluids or vasopressors. A couple of previous studies explored the impact of a fluid bolus on CRT, but little is known about the impact of norepinephrine on CRT when aiming at a higher mean arterial pressure (MAP) target in septic shock. We designed this observational study to further evaluate the effect of a fluid challenge (FC) and a vasopressor test (VPT) on CRT in septic shock patients with abnormal CRT after initial resuscitation. Our purpose was to determine the effects of a FC in fluid-responsive patients, and of a VPT aimed at a higher MAP target in chronically hypertensive fluid-unresponsive patients on the direction and magnitude of CRT response.

Methods
Thirty-four septic shock patients were included. Fluid responsiveness was assessed at baseline, and a FC (500 ml/30 mins) was administered in 9 fluid-responsive patients. A VPT was performed in 25 patients by increasing norepinephrine dose to reach a MAP to 80–85 mmHg for 30 min. Patients shared a multimodal perfusion and hemodynamic monitoring protocol with assessments at at least two time-points (baseline, and at the end of interventions).

Results
CRT decreased significantly with both tests (from 5 [3.5–7.6] to 4 [2.4–5.1] sec, p = 0.008 after the FC; and from 4.0 [3.3–5.6] to 3 [2.6 -5] sec, p = 0.03 after the VPT. A CRT-response was observed in 7/9 patients after the FC, and in 14/25 pts after the VPT, but CRT deteriorated in 4 patients on this latter group, all of them receiving a concomitant low-dose vasopressin.

Conclusions
Our findings support that fluid boluses may improve CRT or produce neutral effects in fluid-responsive septic shock patients with persistent hypoperfusion. Conversely, raising NE doses to target a higher MAP in previously hypertensive patients elicits a more heterogeneous response, improving CRT in the majority, but deteriorating skin perfusion in some patients, a fact that deserves further research.
Multi-rate modulation encoding via unsupervised learning for audio event detection
Authors: Kothinti Sandeep Reddy , Elhilali Mounya 
Published: April 2024

AbstractTechnologies in healthcare, smart homes, security, ecology, and entertainment all deploy audio event detection (AED) in order to detect sound events in an audio recording. Effective AED techniques rely heavily on supervised or semi-supervised models to capture the wide range of dynamics spanned by sound events in order to achieve temporally precise boundaries and accurate event classification. These methods require extensive collections of labeled or weakly labeled in-domain data, which is costly and labor-intensive. Importantly, these approaches do not fully leverage the inherent variability and range of dynamics across sound events, aspects that can be effectively identified through unsupervised methods. The present work proposes an approach based on multi-rate autoencoders that are pretrained in an unsupervised way to leverage unlabeled audio data and ultimately learn the rich temporal dynamics inherent in natural sound events. This approach utilizes parallel autoencoders that achieve decompositions of the modulation spectrum along different bands. In addition, we introduce a rate-selective temporal contrastive loss to align the training objective with event detection metrics. Optimizing the configuration of multi-rate encoders and the temporal contrastive loss leads to notable improvements in domestic sound event detection in the context of the DCASE challenge.
Intelligent code search aids edge software development
Authors: Zhang Fanlong , Li Mengcheng , Wu Heng , Wu Tao 
Published: April 2024

AbstractThe growth of multimedia applications poses new challenges to software facilities in edge computing. Developers must effectively develop edge computing software to accommodate the rapid expansion of multimedia applications. Code search has become a prevalent practice to enhance the efficiency of the construction of edge software infrastructure. Researchers have proposed lots of approaches for code search, and employed deep learning technology to extract features from program representations, such as token, AST, graphs, method name, and API. Nevertheless, two prominent issues remain: 1) there are only a few studies on the effective use of graph representation for code search (especially in Java language), and 2) there is a lack of empirical study on the contributions of different program representations. To address these issues, we conduct an empirical study to explore program representations, especially program graphs. To the best of our knowledge, this is the first attempt to conduct code search with mixed graphs representation for Java language, containing the control flow graph and the program dependence graph. We also present a hybrid approach to capture and fuse the features of a program with representations of Token, AST, and Mixed Graphs (TAMG). The results of our experiment show that our approach possesses the best ability (R@1 with 37% and R@10 with 67.1%). Our graph representation exhibits a positive effect, and the token and AST also have a significant contribution to the code search. Our findings can aid developers in efficiently searching for the desired code while constructing the software infrastructure for edge computing, which is crucial for the rapid expansion of multimedia applications.
A methodological protocol for the development of a national guideline on perioperative management of gastrointestinal tumors in Germany
Authors: Willis M. A. , Post S. , Nothacker M. , Follmann M. , Langer T. , Vilz T. O. 
Published: April 2024

Abstract
Background
The success of abdominal cancer surgery depends not only on the surgery itself but is influenced by the overall perioperative management. Given the multitude of perioperative measures and the ever-increasing number of studies on perioperative management, it is difficult to keep track and provide evidence-based perioperative management. The planned guideline on perioperative management will review the existing evidence and derive treatment recommendations.

Methods
The processing of the evidence is carried out by 6 working groups according to an 8-step scheme: after drafting the guideline questions in PICO format (1), a systematic literature search is carried out (2), and the records found are screened by two independent reviewers from the coordination team. Subsequently, the full texts of the potentially relevant articles are made available to the working groups for full text screening (3). All articles to be included are reviewed for methodological quality (4) before summary of findings tables are generated (5). In line with the GRADE approach, confidence in the evidence is assessed (6) before a recommendation is derived from the evidence, using a modified GRADE Evidence to Decision Framework (7). Finally, all recommendations are compiled and agreed within the guideline group (8).

Discussion
Guidelines serve as foundation for therapy decisions in everyday clinical practice and should therefore be based on up-to-date research results. However, while primary studies and systematic reviews are critically reviewed for their methodological quality, the process of guideline development is often not comprehensible. A protocol with predefined methodology should therefore create transparency and strengthen confidence in the recommendations.

Trial registration
The guideline is registered in the AWMF (Association of the Scientific Medical Societies) Guideline Register (088—010OL).
Assessment and clinical utility of metagenomic next-generation sequencing for suspected lower respiratory tract infections
Authors: Chen Huan , Huang Qiong , Wu Weiwei , Wang Zhiguo , Wang Wei , Liu Yigen , Ruan Fangfang , He Chengzhen , Li Jing , Liu Jia , Wu Guocheng 
Published: April 2024

Abstract
Objectives
This study aims to compare the diagnostic efficacy of metagenomic next-generation sequencing (mNGS) to traditional diagnostic methods in patients with lower respiratory tract infections (LRTIs), elucidate the etiological spectrum of these infections, and explore the impact of mNGS on guiding antimicrobial therapy.

Methods
We retrospectively analyzed data from 128 patients admitted to the Respiratory Department of Anqing 116 Hospital between July 2022 and July 2023. All patients had undergone both mNGS and conventional microbiological techniques (CMT) for LRTI diagnosis. We assessed the diagnostic performance of these methods and examined the influence of mNGS on antimicrobial decision-making.

Results
Overall, mNGS demonstrated superior sensitivity (96.8%) and accuracy (96.8%) compared to CMT. For Mycobacterium tuberculosis detection, the accuracy and sensitivity of mNGS was 88.8% and 77.6%, which was lower than the 94.7% sensitivity of the T-spot test and the 79.6% sensitivity of CMT. In fungal pathogen detection, mNGS showed excellent sensitivity (90.5%), specificity (86.7%), and accuracy (88.0%). Bacteria were the predominant pathogens detected (75.34%), with Mycobacterium tuberculosis (41.74%), Streptococcus pneumoniae (21.74%), and Haemophilus influenzae (16.52%) being most prevalent. Bacterial infections were most common (62.10%), followed by fungal and mixed infections (17.74%). Of the 118 patients whose treatment regimens were adjusted based on mNGS results, 102 (86.5%) improved, 7 (5.9%) did not respond favorably, and follow-up was lost for 9 patients (7.6%).

Conclusions
mNGS offers rapid and precise pathogen detection for patients with suspected LRTIs and shows considerable promise in diagnosing Mycobacterium tuberculosis and fungal infections. By broadening the pathogen spectrum and identifying polymicrobial infections, mNGS can significantly inform and refine antibiotic therapy.
Coexistence of pulmonary arterial hypertension and straight back syndrome in a patient with a novel BMPR2 variant affecting cytoplasmic tail domain
Authors: Tang Mi , Luo Jun , Liu Qingqing , Song Jie 
Published: April 2024

Abstract
Background
Pathologic variants in the bone morphogenetic protein receptor-2 (BMPR2) gene cause a pulmonary arterial hypertension phenotype in an autosomal-dominant pattern with incomplete penetrance. Straight back syndrome is one of the causes of pseudo-heart diseases. To date, no cases of idiopathic or heritable pulmonary arterial hypertension with straight back syndrome have been reported.

Case presentation
A 30-year-old female was diagnosed with pulmonary arterial hypertension by right heart catheterization. Computed tomography revealed a decreased anteroposterior thoracic space with heart compression, indicating a straight back syndrome. Genetic analysis by whole exome sequencing identified a novel c.2423_2424delGT (p.G808Gfs*4) germline frameshift variant within BMPR2 affecting the cytoplasmic tail domain.

Conclusions
This is the first report of different straight back characteristics in heritable pulmonary arterial hypertension with a novel germline BMPR2 variant. This finding may provide a new perspective on the variable penetrance of the pulmonary arterial hypertension phenotype.
Comparative Analysis of Gradient-Boosting Ensembles for Estimation of Compressive Strength of Quaternary Blend Concrete
Authors: Mustapha Ismail B. , Abdulkareem Muyideen , Jassam Taha M. , AlAteah Ali H. , Al-Sodani Khaled A. Alawi , Al-Tholaia Mohammed M. H. , Nabus Hatem , Alih Sophia C. , Abdulkareem Zainab , Ganiyu Abideen 
Published: April 2024

AbstractConcrete compressive strength is usually determined 28 days after casting via crushing of samples. However, the design strength may not be achieved after this time-consuming and tedious process. While the use of machine learning (ML) and other computational intelligence methods have become increasingly common in recent years, findings from pertinent literatures show that the gradient-boosting ensemble models mostly outperform comparative methods while also allowing interpretable model. Contrary to comparison with other model types that has dominated existing studies, this study centres on a comprehensive comparative analysis of the performance of four widely used gradient-boosting ensemble implementations [namely, gradient-boosting regressor, light gradient-boosting model (LightGBM), extreme gradient boosting (XGBoost), and CatBoost] for estimation of the compressive strength of quaternary blend concrete. Given components of cement, Blast Furnace Slag (GGBS), Fly Ash, water, superplasticizer, coarse aggregate, and fine aggregate in addition to the age of each concrete mixture as input features, the performance of each model based onR2, RMSE, MAPE and MAE across varying training–test ratios generally show a decreasing trend in model performance as test partition increases. Overall, the test results showed that CatBoost outperformed the other models withR2, RMSE, MAE and MAPE values of 0.9838, 2.0709, 1.5966 and 0.0629, respectively, with further statistical analysis showing the significance of these results. Although the age of each concrete mixture was found to be the most important input feature for all four boosting models, sensitivity analysis of each model shows that the compressive strength of the mixtures does increase significantly after 100 days. Finally, a comparison of the performance with results from different ML-based methods in pertinent literature further shows the superiority of CatBoost over reported the methods.