bluuebunny/crossref_metadata_2025_split huggingface dataset:
Similarities and variations among lobular carcinoma cells
Authors: Antoniades Kristina , Spector Harvey B. 
Published: February 2007

AbstractA cytomorphological description of lobular carcinoma of the breast is given based on imprints, paraffin‐embedded 5‐μ sections, and plastic‐embedded 2‐μ sections in nine patients. Both nuclear and cytoplasmic features are illustrated and tabulated. A basic lobular carcinoma cell is depicted. Cytoplasmic vacuolization is demonstrated in all tumors. Transitions from one lobular cell variation to another are demonstrated. It is suggested that more precise knowledge of the similarities and the variations in the morphology of the lobular carcinoma cell will help in both cytolagical and histological diagnosis. Diagn Cytopathol 1987;3:55–59.
Neuron‐specific enolase‐positive rosettes in nephroblastoma: A possible diagnostic pitfall in aspiration cytology
Authors: Drut Ricardo 
Published: February 2007

AbstractNeuron‐specific enolase‐positive cells, some arranged in rosettes, were identified in smears obtained in fine‐needle aspiration of a left retroperitoneal tumor found in a 3‐yr‐old boy. Nephrectomy showed a typical nephroblastoma with a prominent blastemic component revealing a positive reaction for neuron‐specific enolase in blastemic and tubular components. Neuron‐specific, enolase‐positive, small malignant cells are not diagnostic of neuroblastoma when coming from a tumor of the retroperitoneum even if rosettes are present. Diagn Cytopathol 1987;3:74–76.
Retroperitoneal lymph node aspiration biopsy in staging of pelvic cancer: A cytological study of 228 consecutive cases
Authors: Cochand‐Priollet B. , Roger B. , Boccon‐Gibod I. , Ferrand J. , Faure B. , Blery M. 
Published: February 2007

AbstractKnowledge of the status of the pelvic lymph nodes is important for accurate staging and adequate treatment of patients with genitourinary tract cancer (bladder and prostatic carcinoma, testicular tumors, and uterine carcinoma). A total of 228 consecutive patients underwent preoperative evaluation of the lymph node status by lymphangiography combined with fine‐needle aspiration biopsy. A lymphadenectomy was performed in 94 patients. The overall diagnostic accuracy was 93%. There were 5% false‐negative results and no false‐positive diagnoses. Fine‐needle aspiration biopsy is an inexpensive method with which to detect the presence of metastatic lymph nodes visualized by bipedal lymphangiography. It is also a safe and well‐tolerated method, with a low morbidity and no mortality. The various cytological features are described as are some possible pitfalls. Diagn Cytopathol 1987;3:102–107.
The use of immunoperoxidase panels for the cytologic diagnosis of malignancy in serous effusions
Authors: Silverman Jan F. , Nance Keith , Phillips Beth , Norris H. Thomas 
Published: February 2007

AbstractThe diagnostic value of an immunoperoxidase panel composed of antisera to carcinoembryonic antigen (CEA), epithelial membrane antigens (EMA), and high‐ and low‐molecular‐weight cytokeratins was evaluated on 39 consecutive pleural and peritoneal fluid specimens and correlated with routine cytologic and histochemical studies. The cases were classified into two groups: malignant (epithelial and small‐cell undiffer‐entiated carcinomas) and benign effusions. We found that the CEA and EMA antisera identified 91% and 100% of the epithelial malignancies, respectively. Mucin stains were positive in only 41% (mucicarmine) and 59% (Alcian blue) of these cases. The battery of cytokeratin markers identified malignant cells from 45%‐100% of the case but showed considerable positive staining of mesothelial cells. A selective review of the literature is presented along with recommendations for technical improvement in immunoperoxidase studies. We believe that an immunoperoxidase panel can be of considerable value in the cytologic diagnosis of epithelial malignancies in effusions. The panel composed of CEA and EMA can prove helpful in a routine cytology practice. Although the cytokeratin marker identified malignant cells, the concomitant immunostaining of mesothelial cells limits its utility. The commercially available panel can be a potential aid in improving the accuracy of serous fluid cytologic examination by decreasing both false‐positive and false‐negative diagnoses and thereby helping to prevent delays in diagnosis and treatment. Diagn Cytopathol 1987;3:134–140.
Fine‐needle aspiration cytology of terminal duct carcinoma of minor salivary gland
Authors: Frierson Henry F. , Covell Jamie L. , Mills Stacey E. 
Published: February 2007

AbstractThe cytologic features of terminal duct carcinoma of the palate, as observed in a fine‐needle aspiration specimen, are described and contrasted with the cytologic features reported for benign mixed tumor, basal‐cell adenoma, and adenoid cystic carcinoma. Terminal duct carcinoma, at times, may be difficult, if not impossible, to distinguish from adenoid cystic carcinoma in fine‐needle aspiration specimens. In most instances, this distinction may not be important. Diagn Cytopathol 1987;3:159–162.
Fine‐needle aspiration cytology of prostatic embryonal rhabdomyosarcoma: A case report
Authors: Henkes David N. , Stein Neil 
Published: February 2007

AbstractFine‐needle aspiration of the prostate has recently gained popularity as a reliable technique in the evaluation of prostatic nodules for malignancy. The cytologic features of adenocarcinoma have been described, but the features of other more unusual tumors have not been widely publicized. We report a case of embryonal rhabdomyosarcoma of the prostate gland with epithelioid cytologic features. Diagn Cytopathol 1987;3:163–165.
Meningeal metastasis of squamous‐cell carcinoma of the uterine cervix: Case report and review of the literature
Authors: Weithman Angela M. , Morrison Gideon , Ingram Ellis A. 
Published: February 2007

AbstractCervical squamous carcinoma metastatic to the central nervous system is an uncommon occurrence. Only eight such cases are reported in the literature. This is a case report of such a metastasis with emphasis on the cytologic features seen in the tumor cells found in the spinal fluid, along with a review of the literature. Diagn Cytopathol 1987;3:170–172.
Endometrial cytology: Six years of experience
Authors: Mencaglia Luca 
Published: February 2007

AbstractThis article deals with a 6‐yr mass screening program for the early detection of endometrial cancer, which took place 1978‐1983. The diagnostic accuracy of endometrial cytology and the possibility of integrating this technique with the hysteroscopy and endometrial biopsy were studied. The authors analyzed 2,504 outpatients, all over the age of 45. The results of endometrial cytology were compared with those found using hysteroscopy and endometrial biopsy. Endometrial cytology showed high sensitivity in diagnosing endometrial cancer (97.7%) and high specificity in diagnosing true negatives. However, this technique was not adequate in identifying benign endometrial pathology, e.g., endometrial hyperplasia, polyps, or submucous fibromas. Epidemiological and clinical data in our series were fundamental in establishing mass screening for the early detection of endometrial cancer using integrated techniques. These data should be taken into consideration for creating new projects. The significantly high prevalence of endometrial neoplasia even in asympomatic women over 45 years of age (4 per 1000) and the possibility of improving the accuracy of endometrial diagnosis using hysteroscopy and endometrial biopsy were the cornerstones of this project.
The cytological features and DNA content of cervical adenocarcinoma
Authors: Kudo Ryuichi , Sagae Satoru , Hayakawa Osamu , Kusanagi Tetsuya , Hashimoto Masayoshi 
Published: February 2007

AbstractThe relationship among cytological features, DNA content, and degree of histological differentiation of cervical adenocarcinoma was investigated in an attempt to discover a more accurate means of screening for this cancer. In highly differentiated adenocarcinoma (so‐called adenoma malignum), the nuclei were only somewhat more irregular in size and shape than those of normal columnar epithelial cells. The cells were arranged in slightly multilayered clusters. The cells of well‐differentiated adenocarcinoma were usually columnar in shape, and they exfoliated side by side in clusters. In moderately differentiated adenocarcinoma, solitary cells with markedly atypical nuclei were combined with multilayered cell clusters. The cells from poorly differentiated adenocarcinoma were roundish, occurred as solitary cells or irregularly overlapping cell clusters, and showed markedly atypical nuclei. As the degree of histological differentiation decreased, as determined by measurement of the DNA content of the cells, the DNA distribution covered a wider range in terms of ploidy, and the number of cells exceeding tetraploid DNA content increased.
Malignant carcinoid of the pancreas: A cytologic, ultrastructural, and immunocytochemical study of a case diagnosed by fine‐needle aspiration of a supraclavicular node metastasis
Authors: Khorsand Jila , Katz Ruth L. , Savaraj Niramol 
Published: February 2007

AbstractCarcinoid tumor of the pancreas is extremely rare. This article describes the case of a 22‐yr‐old woman who manifested a typical carcinoid syndrome; a definitive diagnosis of a metastatic carcinoid tumor was made from needle aspiration of a supraclavicular lymph node using morphologic, immunocytochemical, and ultrastructural criteria. The carcinoid tumor was subsequently shown to be of pancreatic origin.
Subepithelial organisms in trichomonal cervicitis
Authors: Gardner William A. , Culberson Donald E. , Stafford Jesse R. 
Published: February 2007

AbstractTrichomonas vaginalis is usually described as a surfacedwelling, noninvasive organism. Most studies of the pathogenicity of this organism have been derived from cytologic studies of uterine cervical epithelium. We employed specific immunoperoxidase techniques that allow the identification of organisms in cytologic and histologic specimens. In a case of trichomonal cervicitis these organisms were demonstrated both on the epithelial surface and in subepithelial tissues. Interpretations and implications of these findings are discussed.
Fine‐needle aspiration cytology of neoplastic cysts of the pancreas
Authors: Jones Edward C. , Suen Kenneth C. , Grant Dennis R. , Chan Norman H. 
Published: February 2007

AbstractHerein is reported the cytologic features of four cases of cystic neoplasms of the pancreas as seen in fine‐needle aspirates. Cytologically, the cases fall into two distinct groups: mucinous cystic neoplasm and serous cystadenoma. The aspirates from the mucinous cystic neoplasms characteristically showed columnar mucus‐secreting epithelial cells, some of which were arranged in a papilloglandular pattern, with abundant mucous material in the background. The aspirates from the serous cystadenoma yielded small sheets of cuboidal cells with small nuclei and clear cytoplasm, without a background of mucous material. This cytologic division corresponds closely to the histologic classification proposed by Compagno and Oertel and hence is of prognostic and therapeutic value. The diagnostic challenges confronted by the cytopathologist are (1) to differentiate neoplastic cysts from the inflammatory pseudocysts; (2) to differentiate neoplastic epithelium from the normal epithelium of the bowel and pancreatic ducts; and (3) to differentiate mucinous cystic neoplasms from serous cystadenomas.
Fine‐needle aspiration biopsy in the diagnosis of metastases in the liver
Authors: Bizjak‐Schwarzbartl Marija 
Published: February 2007

AbstractDuring the years 1975–1985, fine‐needle aspiration biopsy of the liver was performed in 655 patients. The procedure entailed no complications. In 302 (46%) cases, the samples contained malignant cells; in 238 (36%), liver cells; in 46 (7%), cells suspected of malignancy; in 69 (11%) of cases, the samples were unsatisfactory. The medical records of 242 patients were reviewed. Based on the results of different examinations, it was established that 149 patients had liver metastases and 62 did not. In 31 patients, evaluation could not be done owing to insufficient data. The cytological findings were compared with the results of liver scintiscan. Alcaline phosphatase, serum gamma‐glutamyltranspeptidase, and histological diagnoses. There were no false‐positive cytological diagnoses. False‐negative diagnoses were found in 14% of cases. Cytologically positive samples from known primaries were reviewed. It has been established that pallisade‐like formations are characteristic for metastases of intestinal carcinoma; usually in these cases, necrotic material and inflammatory cells were found as well. Diagn Cytopathol 1987;3:278‐83.
Aspiration cytology of lipomatous tumors: A 10‐year experience at an orthopedic oncology center
Authors: Åkerman Måns , Rydholm Anders 
Published: February 2007

AbstractThe cytodiagnoses of preoperative fine‐needle aspirate smears from 72 histologically proven lipomatous tumors (52 lipomas and 20 liposarcomas of varying type) collected during the 10‐yr period 1972–1981 were correlated to the corresponding histopathologic diagnoses. Three out of 52 lipomas were erroneously diagnosed as low‐grade malignant liposarcomas, and one out of 20 liposarcomas was falsely diagnosed as a benign soft‐tissue tumor. Of the 20 liposarcomas, 15 were cytologically diagnosed as such, and the majority of the myxoid and the pleomorphic liposarcomas were correctly diagnosed as to type. Important differential diagnostic problems were, on one hand, the separation of lipoma with regressive changes and histiocytic reaction and lipoma with chondroid metaplasia from low‐grade malignant liposarcoma and, on the other hand, liposarcoma from intramuscular myxoma, myxofibrosarcoma, and malignant fibrous histiocytoma. The differential diagnosis of liposarcoma as opposed to other soft‐tissue sarcomas is discussed, and it is concluded that preoperative fine‐needle aspiration of lipomatous tumors is of value in the management of these tumors. Diagn Cytopathol 1987;3:295–302.
Cytostructural localization of peanut lectin binding in fine‐needle aspirates of benign and malignant breast lesions
Authors: Henry Michelle J. , Horwitz Charles A. , Stanley Michael W. 
Published: February 2007

AbstractNumerous studies have employed lectin binding patterns to investigate alterations in cell surface polysaccharide expression associated with malignant transformation. Cytostructural relocalization of peanut lectin (Arachis hypogaea) binding sites from the cell surface to the cytoplasm has been described in breast carcinomas. To investigate the possible utility of peanut lectin binding patterns in the diagnosis of breast fine‐needle aspirations, the PNA immunoperoxidase method was applied to smears from a group of 15 benign and malignant breast lesions. Cytostructural relocalization of PNA binding was seen in both benign and malignant breast lesions, indicating that it is of little diagnostic utility in the assessment of malignancy. This finding was noted in both cytologic and histologic preparations. Diagn Cytopathol 1987;3:310‐3.
Gangliocytic paraganglioma of the duodenum: Report of cytologic, histologic, immunohistochemical, and ultrastructural features of a case
Authors: Guarda Luis A. , Ordóñez Nelson G. 
Published: February 2007

AbstractA case of gangliocytic paraganglioma of the duodenum is reported, including light microscopic, ultrastructural, and immunohistochemical characteristics. The cytologic appearance, as might be seen in fine‐needle aspiration smears, indicates a neoplasm with three cellular components (epithelioid, ganglion, and spindle cells) seen histologically by light and electron microscopy. Diagn Cytopathol 1987;3:314‐9.
Fine‐needle aspiration of fibromatosis of the breast
Authors: El‐Naggar Adel , Abdul‐Karim Fadi W. , Marshalleck Josephine J. , Sorensen Kelly 
Published: February 2007

AbstractPercutaneous fine‐needle aspiration of breast fibromatosis yielded clusters of uniform spindle cells. The differential diagnosis of spindle stromal cells obtained by fine‐needle aspiration of the breast is discussed. This includes a wide spectrum of both benign and malignant breast lesions that have to be considered prior to suggesting the diagnosis of fibromatosis. Diagn Cytopathol 1987;3:320‐2.
Cytodiagnosis and monitoring of acute lymphocytic leukemia and eosinophilia in cerebrospinal fluid
Authors: Coleman Anne , Schumann G. Berry 
Published: February 2007

AbstractA case of adult aleukemic leukemia with an isolated CNS relapse diagnosed by cytologic examination of the CSF is reported. CSF hypereosinophilia of uncertain significance was documented. Immunologic marker studies (CALLA, HTA, Tdt) were performed on the CSF and showed a null cell acute lymphocytic leukemia. Sequential CSF specimens were obtained to determine the continued presence of lymphoblasts. Cytologic monitoring of the CSF in acute leukemia is a useful technique to determine disease status and efficacy of therapy. We advocate the use of cell morphology for monitoring, reserving the use of cell markers for initial identification of malignant cells and for use when the cell morphology is altered. Diagn Cytopathol 1987;3:330‐4.
Aspiration biopsy cytology of mammary myoepithelioma
Authors: Nguyen Gia‐Khanh , Shnitka Theodor K. , Jewell Laurence D. 
Published: February 2007

AbstractA case of ultrastructurally confirmed myoepithelioma of the breast studied by fine‐needle aspiration biopsy is reported. Aspirated tumor cells were spindle‐shaped with well‐defined cytoplasm and oval nuclei showing no remarkable nuclear pleomorphism. They were seen mainly in irregular bundles with strong cellular cohesiveness. Their cytoplasm contained S‐100 protein demonstrated by the peroxidase antiperoxidase staining technique. Diagn Cytopathol 1987;3:335‐8.
Cytomorphologic changes in split‐course radiation‐treated bronchogenic carcinomas
Authors: Albright Craig D. , Hafiz Mohammad A. 
Published: February 2007

AbstractThe cellular changes produced by radiation therapy were studied in cytologic specimens from seven patients with bronchogenic carcinoma: squamous‐cell carcinoma (four patients), adenocarcinoma (two patients), and small‐cell undifferentiated carcinoma (one patient). Cytologic samples were obtained from sputum and bronchoscopic examination in patients before and after they received a course of radiation. The cells were studied by light microscopy. An increase in the percentage of columnar cells was detected in five of seven patients independent of the latency of cytologic sampling posttherapy. The percentage of macrophages was unchanged in patients sampled at 15, 18, and 24 mo after the last radiation dose; leukocytes were decreased in relative frequency in the majority of patients studied. Following irradiation, moderately atypical and severely atypical metaplastic cells were increased in relative frequency (48% versus 15% and 19% versus 3%, respectively) and malignant cells were decreased (40% versus 22%) or absent in all patients, irrespective of the type of carcinoma. Nuclear vacuolation, nuclear enlargement, loss of chromatin texture, and rupture of the chromatinic rim were seen in atypical and cancer cells. Infiltration of cancer cells by leukocytes was observed in two of four patients with squamous‐cell carcinoma. In all treated patients, morphologic observations indicated that irradiation produces similar damage to “normal” bronchial epithelial cells although such changes are less apparent at longer time intervals following therapy.
Semiquantitative criteria for fine‐needle biopsy diagnosis: Reduced false‐negative diagnoses
Authors: Hamburger Joel I. , Husain Mujtaba 
Published: February 2007

AbstractAdequate sampling is important to minimize the risk of false‐negative fine‐needle biopsy (FNB) diagnoses. This article reports a prospective study of the following criteria for adequacy of sampling for FNB benign diagnoses: at least six aspirates, at least two of which each contain at least six clusters of benign cells. Of 888 patients studied with FNB, 60 had FNB diagnoses of malignancy; 58 were surgically confirmed, and there was one false positive. Seven of eight nodules with diagnoses of suspected malignancy were excised; three were malignant. Fifty‐seven nodules had diagnoses of cellular or Hurthle‐cell adenomas; 35 were excised, and four were malignant. All 33 nodules excised after benign diagnoses (including Hashimoto's thyroiditis) were benign. Five of 23 FNBs with small numbers of benign cells were malignant, but false‐negative FNB diagnoses were avoided because of adherence to the proposed criteria for adequacy of sampling.
Cytologic diagnosis of papillary carcinoma of the breast in needle aspirates
Authors: Naran Sarla , Simpson John , Gupta Raj K. 
Published: February 2007

AbstractEleven cases of rare papillary carcinoma of the breast diagnosed by fine‐needle aspiration cytology (FNAC) are reported. Five of these were pure papillary carcinomas and six were mixed papillary and ductal, lobular, or mucinous carcinomas. In each case, cytological material was collected by washing the needle and syringe contents into 30% alcohol in saline, and the Gelman cytosieve method was used for the cytological preparations. In this article, the cytological features of these tumors are described, including the presence of single papillae and papillary clusters, tall columnar cells, diathesis of blood with hemosiderin‐laden macrophages, naked nuclei, and high cell recovery.
Immunocytological demonstration of HSV‐II antigen on exfoliated cells from precancerous and cancerous lesions of the uterine cervix
Authors: Gupta M. M. , Sharma B. K. , Singh Veena , Luthra Usha K. 
Published: February 2007

AbstractCancer of the uterine cervix is the most common malignancy among Indian women. Evidence has shown that cervical cancer is preceded by dysplastic, or precancerous, lesions. HSV‐II has been associated with this process of cervical carcinogenesis. We collected 167 cervical smears that had been diagnosed as normal, dysplastic, or carcinoma‐in‐situ and found a significantly high positivity of HSV‐II antigen in women with cervical dysplasia (38.8%) and carcinoma‐in‐situ (33.3%) versus women with normal cytology (17.02%). Latent HSV‐II infection of cervical epithelium may be considered of prognostic value to identify a population at high risk for cervical cancer.