bluuebunny/crossref_metadata_2025_split huggingface dataset:
Global Energy Security and Its Geopolitical Impediments—The Case of the Caspian Region
Authors: Amineh Mehdi Parvizi , Houweling Henk 
Published: August 2007

AbstractThis article discusses the global geopolitics of energy security in the post-Cold War environment. Energy companies headquartered in western countries have long history of accessing energy resources beyond borders through invasion of the host by their home state, followed by domination and the creation of property rights to explore and sell oil. Conquest and domination, respectively voluntary exchange are the survival strategies of human groups in the global system. The article differentiates between demand-induced scarcity, supply-induced scarcity, structural scarcity, and the creation and transfer of property rights. Together, the behaviors referred to by these concepts create a field of social forces that cross state borders and involve state and non-state actors. Monopolizing control over energy resources by the Anglo-Saxon maritime powers was one of the causes of both world wars. Since the collapse of the Soviet Union, the US has been creating a land-based extension of its post-World War II defense perimeter. It runs from Romania, via Central Eurasia, to Israel, Afghanistan, and Pakistan. Overland transport increasingly connects economies and energy supplies on the Central European and Pacific sides of the Eurasian continent. The US, therefore, has decided to bring under its military umbrella the energy-carrying region between industrializing China and India, recovering Russia and unifying Europe. China's policy to secure its energy supply by direct contracting with the home state and legal owner of the stock, brings it into confrontation with the US. The latter consumes one-quarter of the energy assumed to be present in the Greater Middle East. In recent decades, the Chinese economy has been growing at a rate substantially above the worldwide growth rate, which implies that China's share in the world economy is increasing over time. Accordingly, China is becoming more dependent on imports, especially energy. The US domestic oil production peaked in 1970-71. Thus, the US has no spare capacity to provide its allies in Europe and East Asia in case of an interruption of supply. The conquest of Iraq by the US and its allies, and the transfer of the management of the oil sector from the state to a US tax-paying private company opens a new era of violent interstate competition for access to and control of fossil energy sources.
China and the Greater Middle East: Globalization No Longer Equals Westernization
Authors: Radtke Kurt 
Published: August 2007

AbstractThe reshaping of the domestic social, political, and economic structures all over East Asia takes place in the context of a restructuring of the international (security) order. Despite China's increasing acceptance of international institutions and regimes the divergence of vital security interests of the United States (US) and Japan vis-a-vis those of China has raised the specter of increased polarization. This article will seek to answer the question of whether China is about to consciously challenge the power of the US and its allies not only in Asia, but also in the Greater Middle East (GME), mainly through China's impact on the economics, political, and social structure of those countries rather than through rivalry in the field of military power. China's conceptualization of the current global order is also shaped by historical memories of an age in which China was merely an object of Great Power politics which also directly affected the wider region, including the heartland of Eurasia, Southeast Asia, and in particular Japan and the Korean peninsula with their direct impact on China's security equation. To some Chinese strategists the Indian Ocean and countries of the GME have acquired a vital importance not only with regard to the supply of raw materials (including those obtained from Africa). Continuing Western strategic dominance in this large area would also have an important negative impact on China's global strategic position. For the first time in its history, China has become critically dependent on the acquisition of foreign resources—raw materials, investment and technology, as well as earnings from exports. China's economic activities in near neighbors such as Japan, South Korea, Pakistan, ailand, and Iran are also strategically important due to the impact on domestic and international politics of these countries. The US tends to interpret such influence in terms of Chinese power projection. This article interprets the linkages between domestic events and international strategies on the network of global (security) relations in terms of neogeopolitics rather than mainstream US scholarship.
The Changing Face of the Russian Far East: Cooperation and Resource Competition Between Japan, Korea, and China in Northeast Asia
Authors: Kangas Roger 
Published: August 2007

AbstractWhen significant changes take place in one part of the world, it is to be expected that effects will be felt elsewhere. Particularly in an era of increasing globalization, as regions and countries become inextricably linked to each other, what takes place in one region will be felt in another. This is clearly the case with the Greater Middle East (GME). As this region expands in scope and composition, those areas on the borders must deal with the consequences. For example, much attention is placed on European reactions to and relations with the GME. Whether it is it terms of energy transfers, European Union programs regarding a "dialogue with Islam," or NATO's "Mediterranean Dialogue," there is a strong sense that Europeans must remain engaged with the region. However, can the same be said for states to the East particularly in the Far East? Is there a connection, and if so, how does this region relate to the GME? In short, why should someone examining the intricacies of state and societal development in the GME care about what takes place in the Russian Far East? There are several reasons that will be assessed in this article. First, the uncertainty of resource management and exploitation in the GME does mean that states in the Far East need to evaluate their own resource capabilities and needs. Developments within the GME necessitate a more thorough evaluation of what exists in the Far East for the countries in the region. Second, this sense of resource needs is in contrast to a political reality in the region: the major states have their own national security concerns located in other areas, thus creating a political and security "void." Russia, for example, gives higher priority to the West (Europe) and the South (Middle East). China remains committed to security concerns to the Southeast (Taiwan) and increasingly to the West (Central Asia and South Asia). Are the states in question devoting enough attention to the area that intersects them all? Third, if the states in the region believe that regional cooperation is important to address the first part above, the realities of the second part will most likely dampen any chance at true cooperation and regional development. How to overcome these problems and prevent the region from becoming a true "void" is the challenge of the states in the Far East today and in the future. A proper analysis of these security issues requires that one examine the perceptions held within the region, the capabilities and limitations of the respective governments, and an understanding of how these geopolitical differences have played out in the past.
The EU's Policies of Security of Energy Supply Towards the Middle East and Caspian Region: Major Power Politics?
Authors: Hoogeveen Femke , Perlot Wilbur 
Published: August 2007

AbstractVast reserves of fossil fuels make the Greater Middle East (GME) region the centre of attention in terms of security of supply considerations of all major energy-consuming countries, most notably of the United States (US), China, India, and of the European Union (EU). Although energy security is on the EU's agenda, the supranational nature of the EU inhibits it to pursue an external energy security policy in the same way as other consuming countries. Its power, mandate, and in many ways preparedness to execute a common foreign policy towards the GME, let alone as specific as a common foreign energy strategy, are limited. This article seeks to answer the questions of what role the EU wants to play in the GME region in relation to objectives of energy security, what role it can play in this respect, and whether the EU's Middle East politics can be regarded as major power politics.
hDectin-1 is involved in uptake and cross-presentation of cellular antigens
Authors: Weck Markus M. , Appel Silke , Werth Daniela , Sinzger Christian , Bringmann Anita , Grünebach Frank , Brossart Peter 
Published: August 2007

AbstractHuman Dectin-1 (hDectin-1) is a member of the C-type lectin–like receptor family that was shown to be the major receptor for fungal beta-glucans and to play an important role in the cellular responses mediated by these carbohydrates. In this study, we demonstrate that hDectin-1 is involved in the uptake and cross-presentation of cellular antigens. Furthermore, activation of monocyte-derived dendritic cells (MDCs) with toll-like receptor 3 (TLR3) ligand but not with TLR2 ligand or TLR7 ligand resulted in down-regulation of hDectin-1 expression and reduced phagocytosis of apoptotic tumor cells as well as presentation of pp65-derived T-cell epitopes upon engulfment of cytomegalovirus (CMV)–infected human foreskin fibroblasts.
NOTCH1 pathway activation is an early hallmark of SCL T leukemogenesis
Authors: Göthert Joachim R. , Brake Rachael L. , Smeets Monique , Dührsen Ulrich , Begley C. Glenn , Izon David J. 
Published: August 2007

Abstract
The acquired activation of stem cell leukemia (SCL) during T lymphopoiesis is a common event in T-cell acute lymphoblastic leukemia (T-ALL). Here, we generated tamoxifen (TAM)–inducible transgenic mice (lck-ERT2-SCL) to study the consequences of acquired SCL activation during T-cell development. Aberrant activation of SCL in thymocytes resulted in the accumulation of immature CD4+CD8+ (double-positive, DP) cells by preventing normal surface expression of the T-cell receptor αβ (TCRαβ) complex. SCL-induced immature DP cells were further characterized by up-regulated NOTCH1 and generated noncycling polyclonal CD8+TCRβlow cells. The prevalence of these cells was SCL dependent because TAM withdrawal resulted in their disappearance. Furthermore, we observed that SCL activation led to a dramatic up-regulation of NOTCH1 target genes (Hes-1, Deltex1, and CD25) in thymocytes. Strikingly, NOTCH1 target gene up-regulation was already observed after short-term SCL induction, implying that enhanced NOTCH signaling is mediated by SCL and is not dependent on secondary genetic events. These data represent the basis for a novel pathway of SCL-induced leukemogenesis and provide a functional link between SCL and NOTCH1 during this process.
Multiagent induction and maintenance therapy for patients with refractory immune thrombocytopenic purpura (ITP)
Authors: Boruchov Donna M. , Gururangan Sri , Driscoll M. Catherine , Bussel James B. 
Published: August 2007

Abstract
Patients with severe immune thrombocytopenic purpura (ITP) may require an acute increase in the platelet count for surgery or ongoing hemorrhage as well as long-term maintenance treatment. Certain of these patients may be refractory to steroids, intravenous anti-D, intravenous immunoglobulin (IVIG), and splenectomy. Therefore, acute platelet increases were studied in 35 patients completely unresponsive to IVIG or high-dose steroid treatment. Because of their lack of response to either or both single agents, these patients were administered a 3- or 4-drug combination including IVIG 1 g/kg, intravenous methylprednisolone 30 mg/kg, Vinca alkaloids (VCR 0.03 mg/kg), and/or intravenous anti-D (50-75 μg/kg). Subsequent maintenance therapy with the oral combination of danazol (10-15 mg/kg) and azathioprine (2 mg/kg) was given to 18 of the 35 patients. Seventy-one percent of the patients responded to the intravenous combination treatment with acute platelet increases of at least 20×109/L to a level greater than 30×109/L. Two thirds of the patients given maintenance therapy achieved stable platelet counts greater than 50×109/L without other treatments. One patient developed an ileus, but otherwise there was little toxicity of combination treatment. Combination chemotherapy is a useful approach for patients with ITP refractory to conventional treatments both for acute induction and for long-term maintenance therapy.
Homocysteine inhibits endothelial cell growth via DNA hypomethylation of the cyclin Agene
Authors: Jamaluddin Md S. , Chen Irene , Yang Fan , Jiang Xiaohua , Jan Michael , Liu Xiaoming , Schafer Andrew I. , Durante William , Yang Xiaofeng , Wang Hong 
Published: August 2007

AbstractWe reported previously that homocysteine (Hcy) inhibits endothelial cell (EC) growth by transcriptional inhibition of the cyclin A gene via a hypomethylation-related mechanism. In this study, we examined the effect of Hcy on epigenetic modification of the cyclin A gene and its biologic role in human ECs. Cyclin A mRNA levels were significantly suppressed by Hcy and a DNA methyltransferase inhibitor. The cyclin A promoter contains a CpG island spanning a 477-bp region (−277/200). Bisulfite sequencing followed by polymerase chain reaction (PCR) amplification of the cyclin A promoter (−267/37) showed that Hcy eliminated methylation at 2 CpG sites in the cyclin A promoter, one of which is located on the cycle-dependent element (CDE). Mutation of CG sequence on the CDE leads to a 6-fold increase in promoter activity. Hcy inhibited DNA methyltransferase 1 (DNMT1) activity by 30%, and reduced the binding of methyl CpG binding protein 2 (MeCP2) and increased the bindings of acetylated histone H3 and H4 in the cyclin A promoter. Finally, adenovirus-transduced DNMT1 gene expression reversed the inhibitory effect of Hcy on cyclin A expression and EC growth inhibition. In conclusion, Hcy inhibits cyclin A transcription and cell growth by inhibiting DNA methylation through suppression of DNMT1 in ECs.
Nuclear and mitochondrial data reveal different evolutionary processes in the Lake Tanganyika cichlid genus Tropheus
Authors: Egger Bernd , Koblmüller Stephan , Sturmbauer Christian , Sefc Kristina M 
Published: August 2007

Abstract

Background
Cichlid fishes are notorious for their wealth of intra- and interspecific colour pattern diversity. In Lake Tanganyika, the endemic genus Tropheus represents the most impressive example for geographic variation in the pattern and hue of integument colouration, but the taxonomy of the over 100 mostly allopatric colour morphs remains to a large degree unresolved. Previous studies of mitochondrial DNA sequence data revealed polyphyly of the six nominally described species and complex phylogeographic patterns influenced by lake level fluctuations and population admixture, and suggested the parallel evolution of similar colour patterns in divergent evolutionary lineages. A gene tree of a rapidly radiating group may be subject to incomplete and stochastic lineage sorting, and to overcome this problem we used multi-locus, nuclear AFLP data in comparison with mtDNA sequences to study diversification, migration and introgression in Tropheus colour morphs in Lake Tanganyika.

Results
Significant incongruence between phylogenetic reconstructions from mitochondrial and AFLP data suggested incomplete sorting of mitochondrial haplotypes as well as frequent introgression between differentiated lineages. In contrast to the mitochondrial phylogeny, the AFLP phenogram was largely congruent with species classifications, colour pattern similarities, and in many cases also with the current geographic distribution of populations, and did not produce evidence of convergent colour pattern evolution. Homoplasy in the AFLP data was used to identify populations that were strongly affected by introgression.

Conclusion
Different evolutionary processes were distinguished by the combination of mitochondrial and AFLP data. Mitochondrial phylogeographic patterns retained signals of large-scale migration events triggered by historical, major lake level fluctuations, whereas AFLP data indicated genetic cohesion among local groups of populations resulting from secondary contact of adjacent populations in the course of the more frequently occurring, minor lake level fluctuations. There was no support for the parallel evolution of similar colour patterns in the AFLP data. Genetic signatures of introgression and hybridisation detected in several populations suggest that lake level fluctuations drove the stunning diversification of Tropheus morphs not only through population fragmentation, but also by promoting hybridisation between differentiated morphs in secondary contact.
Subclinical sympathetic neuropathy appears early in the course of Crohn's disease
Authors: Ohlsson Bodil , Sundkvist Göran , Lindgren Stefan 
Published: August 2007

Abstract
Background
We have previously demonstrated that patients with Crohn's disease (CD) of long duration have signs of autonomic neuropathy. The aim of this study was to examine whether autonomic neuropathy is an early manifestation of CD, or a sign appearing late in the course.

Methods
Twenty patients, median age 40 years, with a short duration of CD were included. Examination of autonomic reflexes included heart rate reaction to tilt (acceleration index – AI, brake index – BI) and heart rate variation to deep-breathing (expiration/inspiration index-E/I). Seven years later the same examinations were repeated, and in addition we examined the vasoconstriction response to indirect cooling by laser Doppler (vasoconstriction-index – VAC-index). The results were compared with healthy individuals.

Results
There was no difference in the blood pressure between controls and the patients with CD at rest, but eight minutes after tilt, the systolic blood pressure was lowered in patients compared to controls, both at the first assessment (p = 0.016) and after seven years (p = 0.042). The change in systolic blood pressure between rest and eight minutes after tilt was not significant at the first assessment, while a significant change compared to controls was observed seven years later (p = 0.028). This indicates a progressive dysfunction. There were no differences in E/I, AI, BI or VAC indexes between patients and controls.

Conclusion
Patients with CD suffer from autonomic neuropathy early in their disease, suggesting involvement of many different organ systems in this entity.
Susceptibility to type 1 diabetes conferred by the PTPN22C1858T polymorphism in the Spanish population
Authors: Santiago Jose Luis , Martínez Alfonso , de la Calle Hermenegildo , Fernández-Arquero Miguel , Figueredo M Ángeles , de la Concha Emilio G , Urcelay Elena 
Published: August 2007

Abstract

Background
The protein tyrosine phosphatase N22 gene (PTPN22) encodes a lymphoid-specific phosphatase (LYP) which is an important downregulator of T cell activation. A PTPN22 polymorphism, C1858T, was found associated with type 1 diabetes (T1D) in different Caucasian populations. In this study, we aimed at confirming the role of this variant in T1D predisposition in the Spanish population.

Methods
A case-control was performed with 316 Spanish white T1D patients consecutively recruited and 554 healthy controls, all of them from the Madrid area. The PTPN22 C1858T SNP was genotyped in both patients and controls using a TaqMan Assay in a 7900 HT Fast Real-Time PCR System.

Results
We replicated for the first time in a Spanish population the association of the 1858T allele with an increased risk for developing T1D [carriers of allele T vs. CC: OR (95%) = 1.73 (1.17–2.54); p = 0.004]. Furthermore, this allele showed a significant association in female patients with diabetes onset before age 16 years [carriers of allele T vs. CC: OR (95%) = 2.95 (1.45–6.01), female patients vs female controls p = 0.0009]. No other association in specific subgroups stratified for gender, HLA susceptibility or age at onset were observed.

Conclusion
Our results provide evidence that the PTPN22 1858T allele is a T1D susceptibility factor also in the Spanish population and it might play a different role in susceptibility to T1D according to gender in early-onset T1D patients.
Health care utilization and costs in Saskatchewan's registered Indian population with diabetes
Authors: Pohar Sheri L , Johnson Jeffrey A 
Published: August 2007

Abstract
Background
The prevalence of diabetes in North American is recognized to be higher in Aboriginal populations. The relative magnitude of health care utilization and expenditures between Aboriginal and non-Aboriginal populations is uncertain, however. Our objective was to compare health care utilization and per capita expenditures according to Registered Indian and diabetes status in the province of Saskatchewan.

Methods
Administrative databases from Saskatchewan Health were used to identify registered Indians and the general population diabetes cases and two controls for each diabetes case. Health care resource utilization (physician visits, hospitalizations, day surgeries and dialysis) and costs for these individuals in the 2001 calendar year were determined. The odds of having used each resource category, adjusted for age and location of residence, was assessed according to Registered Indian and diabetes status. The average number of encounters for each resource category and per capita healthcare expenditures were also determined.

Results
Registered Indian diabetes cases were younger than general population cases (45.7 ± 14.5 versus 58.4 ± 16.4 years, p < 0.001) and fewer were male (42.3% versus 53.2%, p < 0.001). Registered Indians were more likely to visit a physician, be hospitalized or receive dialysis than the general population, regardless of diabetes status. Diabetes increased the probability of having used all resource categories for both Registered Indians and the general population. Per capita health care expenditures for the diabetes subgroups were more than twice that of their respective controls and were 40% to 60% higher for registered Indians than the general population, regardless of diabetes status.

Conclusion
Relative to individuals without the disease, both registered Indians and the general population with diabetes had substantially higher health care utilization and costs. Excess hospitalization and dialysis suggested that registered Indians with and without diabetes experienced greater morbidity than the general population.