bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tillite horizons in the Chamba Himalayas of Himachal Pradesh, North India
Authors: Powell Derek , Saxena Mahendra 
Published: December 2007

Two
extensive
exposures of tillite of probable Lower Carboniferous age occur on Highway 37 between Bharmaur and Tissa, Himachal Pradesh. One lies eight kilometres south of the village of Kalhal, the other five kilometres west of Durgatti (Fig. 1). The two sections lie some fifty kilometres apart along the strike and are between three areas where tillites have previously been recognized, namely, Salt Range, Kashmir and Simla.

Lithology and texture
The tillites in both localities occur within a succession ascribed by McMahon (1883) to the Silurian System. Both comprise grey phyllites containing cobbles, pebbles and sand size grains. The larger clasts are completely surrounded by the matrix Plate 1 and their concentration varies from beds with only one or two cobbles and/or pebbles per square metre, to beds which resemble a polymict conglomerate. The larger fragments are angular to sub-rounded but intense, penetrative deformation has considerably modified original shapes. The tillites are strongly schistose and usually bedding cannot be distinguished. In more conglomeratic horizons, however, bedding is reflected by changes in the concentration of fragments. The clasts are of pure white quartzite, buff limestone and grey phyllite. No igneous or strongly metamorphosed rocks occur.
The ill-sorted nature of the deposits is confirmed in thin section where the matrix consists of single crystal fragments of quartz, calcite and occasional feldspar set in finer mica, quartz, calcite and opaque ore. Recrystallization of mica and ore has occurred and quartz frequently exhibits syntaxial growth rims.
In both localities the tillites are associated with
Structurally complex reservoirs: an introduction
Authors: Jolley S. J. , Barr D. , Walsh J. J. , Knipe R. J. 
Published: December 2007

AbstractStructurally complex reservoirs form a distinct class of reservoir, in which fault arrays and fracture networks, in particular, exert an over-riding control on petroleum trapping and production behaviour. With modern exploration and production portfolios commonly held in geologically complex settings, there is an increasing technical challenge to find new prospects and to extract remaining hydrocarbons from these more structurally complex reservoirs. Improved analytical and modelling techniques will enhance our ability to locate connected hydrocarbon volumes and unswept sections of reservoir, and thus help optimize field development, production rates and ultimate recovery. This volume reviews our current understanding and ability to model the complex distribution and behaviour of fault and fracture networks, highlighting their fluid compartmentalizing effects and storage-transmissivity characteristics, and outlining approaches for predicting the dynamic fluid flow and geomechanical behaviour of structurally complex reservoirs. This introductory paper provides an overview of the research status on structurally complex reservoirs and aims to create a context for the collection of papers presented in this volume and, in doing so, an entry point for the reader into the subject. We have focused on the recent progress and outstanding issues in the areas of: (i) structural complexity and fault geometry; (ii) the detection and prediction of faults and fractures; (iii) the compartmentalizing effects of fault systems and complex siliciclastic reservoirs; and (iv) the critical controls that affect fractured reservoirs.
A damage domain approach to integration of geomechanics and seismic anisotropy for fractured reservoir characterization
Authors: Hall S. A. , Lewis H. 
Published: December 2007

Abstract
The concepts of damage mechanics are proposed as the logical basis for integration of seismic anisotropy based identification and geomechanics based prediction of subsurface fracturing. In such a context a damage tensor can be used to describe the evolution of (anisotropic) degradation of the elastic properties of a rock undergoing deformation. The concepts of damage mechanics are common to both geomechanical and seismic descriptions of rock elasticity but have not previously been connected. In geomechanical simulations of the evolution of geological structures, damage development can be predicted, described and recorded through a single damage tensor representation for each point in the model (with the inclusion of damage by a number of different mechanisms). With appropriate analysis, equivalent information may be determined from anisotropy analysis of seismic reflection data as the seismic wave propagation is sensitive to the total damage. Thus the proposed approaches for parameterization and modelling/analysis, using the damage domain, provide a common quantification of the damage (as detected using seismic data and predicted using geomechanical modelling) that permits integration of the two disciplines. This paper presents the damage-domain theory and linkage between the domains plus practicalities, with respect to both the geomechanical and seismic analyses, with illustration using a simple geomechanical model example.
Stratigraphic control on extensional fault propagation folding: Big Brushy Canyon monocline, Sierra Del Carmen, Texas
Authors: Ferrill D. A. , Morris A. P. , Smart K. J. 
Published: December 2007

Abstract
Mechanical stratigraphy exerts a first-order control on deformation at a range of scales from oilfield-scale structural style to deformation (e.g. fracturing) within an individual reservoir stratum. This paper explores an outcrop example where mechanical stratigraphy in a limestone and shale sequence directly influenced the structural style and distribution of deformation related to the propagation of a ‘seismic-scale’ normal fault that has maximum displacement on the order of 100–500 m and extends for more than 10 km. A monocline developed in Cretaceous Buda Limestone above tectonically thinned Del Rio Clay and faulted Santa Elena Limestone is here interpreted as an extensional fault propagation fold. Monocline limb dips reach 59°. The Del Rio Clay is thinned from approximately 36 m to 1.5 m, whereas the underlying Santa Elena Limestone is offset vertically by approximately 74 m along a steep (approximately 80°) normal fault. This large fault displacement of the Santa Elena Limestone is not transferred upward to the Buda Limestone because of ductile flow within the intervening Del Rio Clay. Although upward fault propagation has been inhibited, thinning of the Del Rio Clay and the resultant extreme displacement gradient at the tip of the fault have forced the Buda Limestone into a monoclinal fold. Two competent packstone and grainstone beds, 6 m and 2.7 m thick and separated by 10.5 m of less competent calcareous shale, comprise the Buda Limestone at this location. Deformation features within the competent Buda beds include bed-perpendicular veins that accommodate bed-parallel extension, and bedding plane slip surfaces with an up-dip sense of shear that offset the veins. Deformation is concentrated in the monoclinal limb and not in the monoclinal hinge regions. Consequently, bed-parallel extension and shear strain are associated with monoclinal dip, not with curvature. These results show that for this structure, bed dip is a better proxy for bed-parallel extension and related fracture dilation than is curvature.
Incorporation of fault properties into production simulation models of Permian reservoirs from the southern North Sea
Authors: Zijlstra E. B. , Reemst P. H. M. , Fisher Q. J. 
Published: December 2007

Abstract
Reservoir compartmentalization is one of the key issues that affects the development and production phase of gas fields. To improve prediction of the effects of compartmentalization on production, a new method has been developed to allow petroleum engineers to incorporate geologically-reasonable fault rock flow properties into upscaled dynamic reservoir simulation models. The first stage of the workflow is to estimate the permeability and capillary characteristics of fault rocks within the field. These data are then combined with estimates of fault rock thickness, derived from outcrop studies, to calculate transmissibility multipliers to take into account the impact of faults on fluid flow within the dynamic model. Our method differs from most others in that we have attempted to account for the two-phase flow properties of fault rocks in the dynamic models from producing reservoirs. Application of the model to real field examples provides far faster history matching than has been achieved previously. In addition, taking into account the multi-phase flow properties of fault rocks explains production behaviour that previous models could not. Although, the focus of this study has been on the Southern Permian Basin in the North Sea, the same approach could be applied to other areas.
The link between a heterogeneous model and its flow response: examples from fault damage zones highlighting issues in domain discretization and flow simulation
Authors: Ma J. , Vaszi A. Z. , Couples G. D. , Harris S. D. 
Published: December 2007

Abstract
Natural fault damage zones (FDZs) are characterized by complex geometries and topologies, and by strongly-contrasting material properties. Accurate simulation of fluid flow in such systems is dependent on the method of discretization and the mathematical representation of the flow. In this paper, we focus on the conceptual and methodological issues that link a model of a heterogeneous system and its flow response. We study FDZs as our example, where each thin fault strand is a barrier to flow. We examine two contrasting discretization schemes and apply them to 2D FDZ models that contain a realistic array of linear fault traces. Both schemes produce results that are generally in good agreement, and agree with the results calculated by a more accurate (but computationally less efficient) reference scheme. However, differences occur when the discretization approach fails to maintain the fault connectivity (topology) of the input model. It is important to guide the modelling by identifying any continuous flow pathways in the matrix linking fluid inlets and outlets (Through-Going Regions, TGRs). We illustrate a new scheme that identifies all TGRs and determines a grid that is just fine enough to resolve them.
Editing faults within tetrahedral volume models in real time
Authors: Tertois A. L. , Mallet J. L. 
Published: December 2007

Abstract
Accurately positioning faults in a geological model is a major concern because they are responsible for offsets of geological sequences. In the tetrahedral models studied in this paper, faults are discontinuities: faces of tetrahedra on either side of a fault are disconnected. Building tetrahedral models can require a large amount of time, especially when there are many faults. We present a tool for making small, real-time, modifications of faults in tetrahedral models arising from geometrical changes required either by new subsurface data or by new interpretations of existing subsurface data. Fault editing is achieved by moving control points on the fault in the tetrahedral grid and by computing a distortion property over an editable volume relative to the control point and spreading this distortion to neighbouring points using the Discrete Smooth Interpolation technique. The editable volume in which tetrahedron vertices are allowed to move is defined by a given distance to the fault. This approach provides a means of editing faults and fault-related features, such as branch-lines.
Kinematically-equivalent but geomechanically-different simulations of fault evolution: the role of loading configurations
Authors: Lewis H. , Hall S. A. , Guest J. , Couples G. D. 
Published: December 2007

Abstract
Geomechanical simulations are used to demonstrate the importance of the way that models are loaded. In this paper the development of permanent damage during faulting using frictional-slip models of a reverse fault is investigated. Although the use of different loads and constraints can produce the same faulted geometry (for the same rock type, and at the same burial depth), the models develop very different stress and strain states. Permanent strain magnitudes and distributions between models are quite dissimilar, including the distributions of permanent dilation and compaction. This work demonstrates that boundary loads and boundary constraints are significant factors in determining what stress and deformation states evolve in the simulation model. The examples also illustrate that final (deformed) geometry alone is a very poor basis from which to predict either stress state or open fracture distribution. Bulk finite strain does not allow a prediction of local principal stress directions, magnitudes, or signs, at least in the vicinity of fault damage zones.
BRCA1 Mutation and Young Age Predict Fast Breast Cancer Growth in the Dutch, United Kingdom, and Canadian Magnetic Resonance Imaging Screening Trials
Authors: Tilanus-Linthorst Madeleine M.A. , Obdeijn Inge-Marie , Hop Wim C.J. , Causer Petrina A. , Leach Martin O. , Warner Ellen , Pointon Linda , Hill Kimberley , Klijn Jan G.M. , Warren Ruth M.L. , Gilbert Fiona J. 
Published: December 2007

Abstract
Purpose: Magnetic resonance imaging (MRI) screening enables early detection of breast cancers in women with an inherited predisposition. Interval cancers occurred in women with a BRCA1 mutation, possibly due to fast tumor growth. We investigated the effect of a BRCA1 or BRCA2 mutation and age on the growth rate of breast cancers, as this may influence the optimal screening frequency.
Experimental Design: We reviewed the invasive cancers from the United Kingdom, Dutch, and Canadian MRI screening trials for women at hereditary risk, measuring tumor size at diagnosis and on preceding MRI and/or mammography. We could assess tumor volume doubling time (DT) in 100 cancers.
Results: Tumor DT was estimated for 43 women with a BRCA1 mutation, 16 women with a BRCA2 mutation, and 41 women at high risk without an identified mutation. Growth rate slowed continuously with increasing age (P = 0.004). Growth was twice as fast in BRCA1 (P = 0.003) or BRCA2 (P = 0.03) patients as in high-risk patients of the same age. The mean DT for women with BRCA1/2 mutations diagnosed at ages ≤40, 41 to 50, and &gt;50 years was 28, 68, and 81 days, respectively, and 83, 121, and 173 days, respectively, in the high-risk group. Pathologic tumor size decreased with increasing age (P = 0.001). Median size was 15 mm for patients ages ≤40 years compared with 9 mm in older patients (P = 0.003); tumors were largest in young women with BRCA1 mutations.
Conclusion: Tumors grow quickly in women with BRCA1 mutations and in young women. Age and risk group should be taken into account in screening protocols.
Estrogen Receptor Status Could Modulate the Genomic Pattern in Familial and Sporadic Breast Cancer
Authors: Melchor Lorenzo , Honrado Emiliano , Huang Jia , Álvarez Sara , Naylor Tara L. , García María J. , Osorio Ana , Blesa David , Stratton Michael R. , Weber Barbara L. , Cigudosa Juan C. , Rahman Nazneen , Nathanson Katherine L. , Benítez Javier 
Published: December 2007

AbstractPurpose: Familial breast cancer represents 5% to 10% of all breast tumors. Mutations in the two known major breast cancer susceptibility genes, BRCA1 and BRCA2, account for a minority of familial breast cancer, whereas families without mutations in these genes (BRCAX group) account for 70% of familial breast cancer cases.Experimental Design: To better characterize and define the genomic differences between the three classes of familial tumors and sporadic malignancies, we have analyzed 19 BRCA1, 24 BRCA2, and 31 BRCAX samples from familial breast cancer patients and 19 sporadic breast tumors using a 1-Mb resolution bacterial artificial chromosome array-based comparative genomic hybridization.Results: We found that BRCA1/2 tumors showed a higher genomic instability than BRCAX and sporadic cancers. There were common genomic alterations present in all breast cancer groups, such as gains of 1q and 16p or losses of 8ptel-p12 and 16q. We found that the presence/absence of the estrogen receptor (ER) may play a crucial role in driving tumor development through distinct genomic pathways independently of the tumor type (sporadic or familial) and mutation status (BRCA1 or BRCA2). ER− tumors presented higher genomic instability and different altered regions than ER+ ones.Conclusions: According to our results, the BRCA gene mutation status (mainly BRCA1) would contribute to the genomic profile of abnormalities by increasing or modulating the genome instability.
Delta-like 4/Notch Signaling and Its Therapeutic Implications
Authors: Yan Minhong , Plowman Greg D. 
Published: December 2007

Abstract
Intense research efforts have been focused toward the identification of regulators of angiogenesis and the development of antiangiogenesis-based cancer therapies. The approval of anti–vascular endothelial growth factor (VEGF) monoclonal antibody (bevacizumab) for use in colorectal and lung cancer provides clinical validation for targeting angiogenesis for the treatment of cancer. Delta-like 4 (Dll4)–mediated Notch signaling represents another key pathway essential for vascular development. Recent studies yield substantial insights into the role of Dll4 in angiogenesis. Dll4 is downstream of VEGF signaling and its activation triggers a negative feedback that restrains the effects of VEGF. Attenuation of Dll4/Notch signaling results in chaotic vascular network with excessive branching and sprouting. In preclinical studies, blocking of Dll4/Notch signaling is associated with a paradoxical increase in tumor vessel density, yet causes marked growth inhibition due to functionally defective vasculature. Dll4 blockade holds promise as an additional strategy for angiogenesis-based cancer therapy, especially when resistance to and/or escape from existing therapies evolve.
Tumors Established with Cell Lines Selected for Oxaliplatin Resistance Respond to Oxaliplatin if Combined with Cetuximab
Authors: Prewett Marie , Deevi Dhanvanthri S. , Bassi Rajiv , Fan Fan , Ellis Lee M. , Hicklin Daniel J. , Tonra James R. 
Published: December 2007

AbstractPurpose: To establish whether cetuximab, a chimeric IgG1 antibody targeting epidermal growth factor receptor, has the potential to restore responsiveness to oxaliplatin in preclinical cancer models, as has been shown with irinotecan in irinotecan refractory metastatic colorectal cancer patients.Experimental Design: The effects of cetuximab and oxaliplatin, alone or in combination, were tested in vitro and in vivo using human colorectal cancer cell lines selected for oxaliplatin resistance, as well as parental control cell lines. Evaluations were made of subcutaneous xenograft tumor growth in nu/nu athymic mice, as well as activation of mitogen-activated protein kinase (extracellular signal-regulated kinase 1/2) and AKT, expression of DNA repair genes, density of apurinic/apyrimidinic DNA damage, and accumulation of platinum-DNA adducts in vitro.Results: Oxaliplatin + cetuximab efficacy in murine subcutaneous xenograft models was greater than that of monotherapies and independent of the responsiveness to oxaliplatin monotherapy. In vitro, cetuximab reduced expression of excision repair cross-complementation group 1 and XPF, which are key components of the nucleotide excision repair pathway involved in the excision of platinum-DNA adducts. In addition, cetuximab reduced expression of XRCC1, a component of the base excision repair pathway responsible for the repair of apurinic/apyrimidinic sites. Effects of cetuximab on DNA repair protein levels were downstream to effects on mitogen-activated protein kinase and AKT pathway activation. In line with effects on DNA repair protein expression, cetuximab increased the accumulation of platinum and apurinic/apyrimidinic sites on DNA during oxaliplatin treatment.Conclusions: Cetuximab has the potential to salvage the benefits of oxaliplatin in oxaliplatin-resistant colorectal cancer patients by reducing DNA repair capacity.
Src Continues Aging: Current and Future Clinical Directions
Authors: Kopetz Scott , Shah Ami N. , Gallick Gary E. 
Published: December 2007

Abstract
Aberrant activation of members of the Src family of nonreceptor protein tyrosine kinases is common in solid tumor malignancies and may contribute to the development and/or progression of these tumors. As a result, four Src inhibitors are now in more than 50 clinical trials for at least 14 different types of solid tumors. In this review, we briefly discuss the preclinical rationale for Src inhibitors, the development strategies most likely to be successful in the clinic, and the rationale for Src inhibitors in combination with other agents as part of a more comprehensive therapeutic strategy. As the use of Src family inhibitors in clinical trials on solid tumors is in its infancy, further studies on the roles of Src family kinases in tumor progression, chemoresistance, epidermal-to-mesenchymal transition, and other properties of tumor progression will be important in designing the most effective clinical trials using these inhibitors.
Mechanisms of Resistance to Histone Deacetylase Inhibitors and Their Therapeutic Implications
Authors: Fantin Valeria R. , Richon Victoria M. 
Published: December 2007

Abstract
Histone deacetylase inhibitors (HDI) are a promising new approach to the treatment of cancer. HDIs have been shown to induce differentiation, cell cycle arrest, and apoptosis in a variety of transformed cell lines; inhibit tumor growth in animal models; and show antitumor activity in clinical trials. Vorinostat, which has shown clinical responses in ∼30% of patients with advanced cutaneous T-cell lymphoma, is the first HDI approved for the treatment of cancer, and it is currently being evaluated in other indications. A better understanding of the molecular determinants of resistance to HDIs may provide the basis for therapeutic combinations with improved clinical efficacy. Poor response to treatment could be linked to systemic factors like pharmacokinetics or to tumor-specific factors both at the level of the malignant cells (tumor intrinsic) or the tumor microenvironment. This review focuses on the tumor intrinsic mechanisms of drug resistance (excluding mechanism of acquired resistance due to chronic exposure). In particular, attention is given to selected mechanisms that are relevant across chemical classes of HDIs and that can aid in the design of rational combination strategies.
Is Cell Death a Critical End Point for Anticancer Therapies or Is Cytostasis Sufficient?
Authors: Rixe Olivier , Fojo Tito 
Published: December 2007

Abstract
Since the discovery of conventional chemotherapy and the development of new target-based agents, the importance of cytostasis in anticancer activity has been debated. This review examines the relative importance of both cytostasis and cytotoxicity based on both preclinical data and clinical reports. Several limitations of our basic and clinical methods to evaluate cytostasis and cytotoxicity will be highlighted. Molecular mechanisms of cytostasis will be analyzed, including interference with the cell cycle as well as putative links with necrosis and autophagy. Finally, we will cite evidence that most older and newer compounds are both cytostatic and cytotoxic. The relative role of cytostasis and cytotoxicity on future drug screening and clinical development will be explored.