bluuebunny/crossref_metadata_2025_split huggingface dataset:
Caring and building friendships in the UK’s asylum system
Authors: Wardale Maria , Scuzzarello Sarah 
Published: March 2024

AbstractTo care and feel cared for are considered fundamental to what makes us human, and what enables us to live and thrive in this world. Yet for the UK’s asylum-seeking population who is living with uncertainties for the future, care appears absent. In such contexts, it is imperative to understand how care is enacted, experienced, and valued amongst spaces and people often considered to be care-less. Drawing on data collected in four collaborative photographic workshops and photo elicitation interviews with asylum seekers and refugees (ASRs) (N: 7), this study aims to gain insight into how ASRs in the UK care and feel cared for and their relative ability to forge friendships during their migration journey. We show how their relationship to caregiving and care-receiving changes over time and is deeply influenced by asylum policies and the refugee experience more generally. Responding to feminist scholars’ calls to disrupt the normative assumptions about how and between whom care is exchanged, this article highlights the diversity of friendships forged while on the move and seeking asylum as well as the caring practices emerging in situations of precarity, the pervasive impacts of the hostile environment on disrupting and distorting such caring relationships, and cautious but agentic and caring ways that ASRs seek to navigate the ambiguities of friendships in hostility. In doing so, the article provides an important counter-narrative to the dominant portrayal of ASRs as passive recipients of care, by highlighting how their way to approach care and friendship varies across time and circumstances.
Forest landowner values and perspectives of prescribed fire in the Northeast/Mid-Atlantic region of the United States
Authors: Regmi Arun , Kreye Jesse K. , Kreye Melissa M. 
Published: March 2024

Abstract
Background
Fire is an important ecological process that shapes structures and compositions in many ecosystems worldwide. Changes in climate, land use, and long-term fire exclusion have altered historic fire regimes often leading to more intense and severe wildfires and loss of biodiversity. There is an increasing interest by resource managers to reintroduce fire in historically fire-dependent ecosystems while enhancing the provision of ecosystem services. Restoring fire, however, is complicated by a diverse mix of public and private land ownerships in regions like the Northeast/Mid-Atlantic US, where private lands make up the majority (~ 70%) but prescribed burning is less common. To help inform policies that promote prescribed burning on private lands, we conducted a regional survey of forest landowners regarding their perspectives and willingness to pay (WTP) for prescribed fire as a management tool. We also used spatial hotspot analysis to detect regional variations in landowner opinions.

Results
Respondents had limited knowledge and experience with burning overall, but many also perceived fire as a low-risk tool and were trusting of burning professionals. Most landowners (64%) expressed interest in a variety of prescribed fire programs to help achieve management outcomes. Preferred outcomes include protecting forest health, controlling invasive species, and wildlife habitat. Also significant in explaining landowner choices were economic (e.g., cost of burning), governance (e.g., state coordination, cost-share assistance, and access to consultants), and demographic factors. According to two models, the mean WTP for the prescribed fire was $10 ha−1 and $40 ha−1 ($4 ac−1 and $16 ac−1) but could be as high as $220 ha−1 ($89 ac−1) for specific outcomes and programs. Spatial analysis revealed a north–south gradient in landowner opinions across the region, with opinions about burning more positive in the south. Pennsylvania landowners were unique within our study in that they placed the highest economic value on prescribed fire, despite having limited knowledge and experience.

Conclusions
There is significant support by landowners to use prescribed fire to achieve management objectives on private lands in the Northeast/Mid-Atlantic region. Pennsylvania landowners, in particular, were strongly motivated to use prescribed fire; however, knowledge and experience are severely limited. Education, technical support, financial assistance, and access to professionals will be important for helping landowners use prescribed fire to achieve management objectives.
Effect of dry needling on quality of life in patients with trigger finger: a randomized controlled trial
Authors: El-halawany Eman Fathy , Yamany Abeer Abd El Rhaman , Gaballah Saad Abdel Atti , Atta Hanaa Kenawy 
Published: March 2024

Abstract
Background
An inflammatory disorder known as trigger finger (TF) results in pain in
the proximal and distal palm and digit, as well as restricted movement and diminished function. Physiotherapists use a specific treatment called dry needling (DN) to reduce musculoskeletal pain and assist patients with mobility restriction.

Objectives
This study aimed to examine the effectiveness of DN on quality of life in patients suffering from trigger finger.

Methods
Forty patients, ranging in age from 45 to 75, were randomized into one of two groups in this Prospective pre and post-test, single-blind parallel group randomized controlled trial. Twenty patients were assigned to the intervention group, which included traditional physiotherapy splinting and ultrasound (ultrasonic dosage was 3MHz, the intensity of 0.5 W/cm2, and the duty cycle 50%. Duration: 5 minutes) as well as to DN upon a nodule at the proximal end of the 1st annular (A1) pulley as well as the discrepancy that existed between the flexor tendon's diameter along with its sheath at the metacarpal head. Twenty patients were assigned to the control group, which consisted of traditional treatment alone, twice weekly, for a total of ten sessions over five weeks. The trial evaluated the quality of life, severity of pain, and hand grip strength using the World Health Organization Quality-of-Life Scale (WHOQOL-BREF), visual analogue scale, and Camry dynamometer respectively two times, beforetreatment and after 10 treatment sessions.

Results
Within-group analysis using MANOVA demonstrated a significant decline in VAS (p = 0.001) and a significant improvement in quality of life (p = 0.001) and hand grip strength (p = 0.001). Regarding between group comparison using MANOVA there was significant improvement in favor of the DN intervention (p = 0.001) for all measured variables.

Conclusions
A 5-week dry needling approach with a traditional physiotherapy program was effective in improving in quality of life, pain intensity, and hand grip strength in patients with trigger finger, emphasizing it as the better option.

Trial registration:
Clinical Trial. Gov, NCT05671523. Registered 14 December 2022.
Involvement of Spinal Neuroplastin 65 in Neuropathic Pain by GABAA Receptor α2 Subunit Regulation
Authors: Xu Li , Wang Yu , Jiao Yang , Huang Yulin , Xu Rui , Gu Xiaoping , Zhang Wei , Ma Zhengliang 
Published: March 2024

BACKGROUND:
Neuropathic pain (NP) is a highly challenging condition with complex pathological mechanisms, and the spinal gamma aminobutyric acid A receptor receptor plays a crucial role in its progression. Recent studies have revealed a potential interaction between neuroplastin 65 (NP65) and gamma aminobutyric acid A receptor α2 subunit (GABAAR-α2) on the cell surface. We hypothesize that NP65 is involved in the pathogenesis of NP by regulating the level of GABAAR-α2.

METHODS:
A chronic constrictive injury (CCI) pain model was established in male Sprague-Dawley rats to verify the change in spinal NP65 expression. Alterations in pain behavior and GABAAR-α2 protein expression were observed after intrathecal injection of NP65 overexpressing adeno-associated virus (AAV) in CCI rats. In vitro investigations on Neuroblastoma 2a cells, the effect of NP65 on GABAAR-α2 expression via the calcineurin-nuclear factor of activated T-cell 4 (CaN-NFATc4) signaling pathway was evaluated by manipulating NP65 expression.

RESULTS:
The expression level of NP65 protein and mRNA in the CCI group were significantly decreased (P < .05; analysis of variance [ANOVA]). After intrathecal injection of NP65, overexpression of AAV and pain behavior in CCI rats were significantly alleviated, and levels of GABAAR-α2 were upregulated. In vitro experiments verified alterations in the expression of GABAAR-α2, CaN, and phosphorylated NFATc4 on the application of NP65 with plasmid or small interfering RNA, respectively. After the application of the specific CaN inhibitor cyclosporine A (CsA), the changes in NP65 expression did not produce subsequent alterations in the expression of GABAAR-α2, CaN, or phosphorylated NFATc4 proteins.

CONCLUSIONS:
NP65 modulates the level of GABAAR-α2 through the CaN-NFATc4 signaling pathway, which may serve as the underlying mechanism of NP.
U.S. Fertility in Life Course Context: A Research Note on Using Census-Held Linked Administrative Records for Geographic and Sociodemographic Subgroup Estimation
Authors: Root Leslie , Stevenson Amanda Jean , Genadek Katie , Yeatman Sara , Mollborn Stefanie , Menken Jane 
Published: March 2024

Abstract
Fertility is a life course process that is strongly shaped by geographic and sociodemographic subgroup contexts. In the United States, scholars face a choice: they can situate fertility in a life course perspective using panel data, which is typically representative only at the national level; or they can attend to subnational contexts using rate schedules, which do not include information on life course statuses. The method and data source we introduce here, Census-Held Linked Administrative Records for Fertility Estimation (CLAR-FE), permits both. It derives fertility histories and rate schedules from U.S. Census Bureau–held data for the nation and by state, racial and ethnic subgroups, and the important life course status of parity. We generate three types of rates for 2000–2020 at the national and state levels by race and ethnicity: age-specific rates and both unconditional and conditional parity- and age-specific rates. Where possible, we compare these rates with those produced by the National Center for Health Statistics. Our new rate schedules illuminate state and racial and ethnic differences in transitions to parenthood, providing evidence of the important subgroup heterogeneity that characterizes the United States. CLAR-FE covers nearly the entire U.S. population and is available to researchers on approved projects through the Census Bureau's Federal Statistical Research Data Centers.
Contralateral Nasofrontal Trephination: A Novel Corridor for a “Dual Port” Approach to the Petrous Apex
Authors: Abouammo Moataz D. , Narayanan Maithrea S. , Alsavaf Mohammad Bilal , Alwabili Mohammed , Gosal Jaskaran Singh , Bhuskute Govind S. , Wu Kyle C. , Jawad Basit A. , VanKoevering Kyle K. , Carrau Ricardo L. , Prevedello Daniel M. 
Published: March 2024

BACKGROUND AND OBJECTIVES:
Expanded endonasal approaches (EEAs) have proven safe and effective in treating select petrous apex (PA) pathologies. Angled endoscopes and instruments have expanded indications for such approaches; however, the complex neurovascular anatomy surrounding the petrous region remains a significant challenge. This study evaluates the feasibility, anatomic aspects, and limitations of a contralateral nasofrontal trephination (CNT) route as a complementary corridor improving access to the PA.

METHODS:
Expanded endonasal and CNT approaches to the PA were carried out bilaterally in 15 cadaveric heads with endovascular latex injections. The distance to the PA, angle between instruments through the 2 approach portals, and surgical freedom were measured and compared.

RESULTS:
Three-dimensional DICOM-based modeling and visualization indicate that the CNT route reduces the distance to the target located within the contralateral PA by an average of 3.33 cm (19%) and affords a significant increase in the angle between instruments (15.60°; 54%). Furthermore, the vertical vector of approach is improved by 28.97° yielding a caudal reach advantage of 2 cm. The area of surgical freedom afforded by 3 different approaches (endonasal, endonasal with an endoscope in CNT portal, and endonasal with an instrument in CNT portal) was compared at 4 points: the dural exit point of the 6th cranial nerve, jugular foramen, foramen lacerum, and petroclival fissure. The mean area of surgical freedom provided by both approaches incorporating the CNT corridor was superior to EEA alone at each of the surgical targets (P = <.001).

CONCLUSION:
The addition of a CNT portal provides an additional avenue to expand on the classical EEA to the PA. This study provides insight into the anatomic nuances and potential clinical benefits of a dual-port approach to the PA.
Highland deer mice support increased thermogenesis in response to chronic cold hypoxia by shifting uptake of circulating fatty acids from muscles to brown adipose tissue
Authors: Lyons Sulayman A. , McClelland Grant B. 
Published: March 2024

ABSTRACT
During maximal cold challenge (cold-induced V̇O2,max) in hypoxia, highland deer mice (Peromyscus maniculatus) show higher rates of circulatory fatty acid delivery compared with lowland deer mice. Fatty acid delivery also increases with acclimation to cold hypoxia (CH) and probably plays a major role in supporting the high rates of thermogenesis observed in highland deer mice. However, it is unknown which tissues take up these fatty acids and their relative contribution to thermogenesis. The goal of this study was to determine the uptake of circulating fatty acids into 24 different tissues during hypoxic cold-induced V̇O2,max, by using [1-14C]2-bromopalmitic acid. To uncover evolved and environment-induced changes in fatty acid uptake, we compared lab-born and -raised highland and lowland deer mice, acclimated to either thermoneutral (30°C, 21 kPa O2) or CH (5°C, 12 kPa O2) conditions. During hypoxic cold-induced V̇O2,max, CH-acclimated highlanders decreased muscle fatty acid uptake and increased uptake into brown adipose tissue (BAT) relative to thermoneutral highlanders, a response that was absent in lowlanders. CH acclimation was also associated with increased activities of enzymes citrate synthase and β-hydroxyacyl-CoA dehydrogenase in the BAT of highlanders, and higher levels of fatty acid translocase CD36 (FAT/CD36) in both populations. This is the first study to show that cold-induced fatty acid uptake is distributed across a wide range of tissues. Highland deer mice show plasticity in this fatty acid distribution in response to chronic cold hypoxia, and combined with higher rates of tissue delivery, this contributes to their survival in the cold high alpine environment.
Childhood experiences and sleep problems: A cross-sectional study on the indirect relationship mediated by stress, resilience and anxiety
Authors: Ashour Rola , Halstead Elizabeth J. , Mangar Stephen , Lin Vanessa Khoo Qi , Azhari Atiqah , Carollo Alessandro , Esposito Gianluca , Threadgold Laura , Dimitriou Dagmara 
Published: March 2024

Background
Childhood experiences either adverse (ACE) or benevolent (BCE) can indirectly impact sleep quality in adult life, which in turn are modulated by the interplay of a variety of factors such as depression, anxiety, resilience and mental health problems.

Methods
A cross-sectional observational study was conducted across the UK and the Middle Eastern countries during the COVID-pandemic on 405 participants. An online survey used a combination of questionnaires to assess ACE and BCEs. The following tools were then used to assess the contribution of resilience, stress, depression and anxiety respectively: Brief Resilience Scale (BRS), Perceived Stress Scale (PSS-10), Patient Health Questionnaire-2 (PHQ-2) and General Anxiety Disorder-2 (GAD-2) scale on childhood experiences. The extent of sleep disturbances experienced over a period of seven days was assessed using the PROMIS Sleep Disturbance Short-Form Tool. A serial-parallel mediation model was used to evaluate the impact of the mediators on childhood experiences and sleep quality.

Results
Over 50% of the cohort were from Middle Eastern countries. Four or more BCEs were experienced by 94.3% of the cohort. In contrast, 67.9% of participants experienced at least one ACE before the age of 18 years, with moderate levels of stress, mild depression and anxiety were reported in 3.7%, 13% and 20% of participants respectively. Whilst 25.4% of participants reported having had four or more ACEs, with higher reports in the middle easter countries (32%). ACEs were found to correlate with sleep disturbance whilst BCEs showed an inverse correlation. The relationship between ACE and sleep disturbances was shown to be mediated by stress, and anxiety, but not by resilience or depression. Resilience and stress, and resilience and anxiety serially mediated the interaction between ACE and sleep disturbance. With regards to BCE, an inverse association with sleep disturbance was recorded with similar mediators of stress and anxiety observed.

Conclusion
This study confirms the negative effects of ACEs, and the positive effects of BCEs on sleep in adulthood which are both mediated predominantly by psychological resilience, anxiety and stress. Strategies aimed at improving psychological resilience as well as addressing stress and anxiety may help improve sleep quality.
The association between zinc and prostate cancer development: A systematic review and meta-analysis
Authors: Shahrokhi Nejad Shahrzad , Golzari Zahra , Zangiabadian Moein , Salehi Amniyeh Khozani Amir Abbas , Ebrahimi Rasoul , Nejadghaderi Seyed Aria , Aletaha Azadeh 
Published: March 2024

Background
Prostate cancer is affecting males globally, with several complications. Zinc can play roles in cancers. We aimed to clarify the association between zinc levels or intake with prostate cancer development.

Methods
We searched PubMed, EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL), and Web of Science until May 1, 2023. We included case-controls and cross-sectionals that measured zinc level and/or intake in patients with prostate cancer or cohorts that evaluated the association between zinc and prostate cancer development. Studies that did not have a healthy control group were excluded. Joanna Briggs Institute was used for quality assessment. Publication bias was evaluated using Egger’s and Begg’s tests and funnel plot.

Results
Overall, 52 studies (n = 44 case controls, n = 4 cohorts, and n = 4 cross sectionals) with a total number of 163909 participants were included. Serum (standardized mean difference (SMD): -1.11; 95% confidence interval (CI): -1.67, -0.56), hair (SMD: -1.31; 95% CI: -2.19, -0.44), and prostatic fluid or tissue zinc levels (SMD: -3.70; 95% CI: -4.90, -2.49) were significantly lower in prostate cancer patients. There were no significant differences in nail zinc level and zinc intake between those with prostate cancer and healthy controls. There was no publication bias except for serum and hair zinc levels based on Begg’s and Egger’s tests, respectively. The mean risk of bias scores were 4.61 in case-controls, eight in cohorts, and seven in cross-sectionals.

Conclusions
Overall, high zinc levels might have a protective role in prostate cancer, which can be used as a therapeutic or preventive intervention. Future large-scale studies are needed to confirm the association.
STUDY OF THE PROCESS OF EXTRACTION OF ISOSALIPURPOSIDE FROM THE FLOWERS OF HELICHRYSUM MARACANDICUM (HELICHRYSUM MARACANDICUM POPOV EX KIRP.)
Authors: Karieva Yokut Saidkarimovna , Sadikova Ranokhon Karimovna , Karimov Otabek Ulugbek Ugli , Nuridullaeva Kamola Negmatilloevna 
Published: March 2024

The purpose of this research is to study the process of extraction of isosalipurposide, and on the basis of the data obtained, the development of an optimal technology for obtaining a dry extract from the flowers of Helichrysum maracandicum (Helichrysum maracandicum Popov ex Kirp.).
In the studies, the circulation extraction method, which is widely used in local pharmaceutical enterprises, was used. Based on the characteristics of the technology for obtaining a dry extract, a four-factor experimental plan based on a 5x5 Greek-Latin square was used to study the extraction process of the target BAS. Four quantitative factors were chosen as variables: the degree of grinding of the raw material (factor A), the concentration of ethyl alcohol (factor B), the hydromodulus (factor C) and the soaking time of the raw material (factor D). The output parameter was the percentage of the sum of flavonoids in terms of isosalipurposide in the resulting product.
The results of dispersion analysis showed that the most complete yield of isosalipurposide was observed with the following indicators of variable factors: raw material grinding – 5–7 mm, extractant – 50% ethyl alcohol, hydromodulus 1 : 5, raw material soaking time – 9 hours. The expediency of using a short-term (10 min) ultrasonic treatment, which allows to increase the yield of the target BAS by 1.12 times, has been proved. The developed technology for obtaining a dry extract has been tested in industrial conditions. The resulting extract of Helichrysum maracandicum flowers in terms of quality met the requirements of pharmacopoeial articles: "Extracts" (SP XIV, GPM.1.4.1.21), "Extracts" (European Pharmacopoeia, 9th edition).
Dry extract of Helichrysum maracandicum is recommended for use as a substance for the production of medicines and dietary supplements.
On the generalized exponential sums and their fourth power mean
Authors: Liu Wencong , Ning Shushu 
Published: March 2024

Abstract
The main purpose of this article is to study the calculating problem of the fourth power mean of the two-term exponential sums and provide an accurate calculating formula for utilizing analytical methods and character sums’ properties. In the meantime, a result of the fourth power mean of Gauss sums is improved.
Bio-based aerogel composites of coconut pith-derived carbon and chitosan for efficient anionic dye-polluted water treatment
Authors: Nguyen Oanh H. , Nguyen Huy T. A. , Nguyen Luon Tan , Do Nga H. N. , Tran Lam Dai , Tran Viet T. , Le Phung K. , Le Kien A. 
Published: March 2024

Abstract
Biomass-based aerogels are of interest due to their abundant precursors, ease of functionalization, eco-friendliness, low cost, and effectiveness in dye-contaminated water treatment. Coconut pith (CP) known as a by-product after coconut processing is a sponge-like and lightweight material discarded in large volumes. For the first time, carbon micro-particles resulting from two-step treatment and pyrolysis of CP have been successfully incorporated with chitosan to produce aerogel composites by high-speed homogenization and freeze-drying. After pretreatment, holocellulose content and crystallinity index of the recovered CP pulp are respectively 75.4 and 58.6 % along with a solid recovery rate of 27.5 %. Characteristic properties of the aerogel composites are featured by their density as low as 15.23–28.17 mg/cm3, remarkably high porosity of 98.17–99.05 %, and Young’s modulus of 1.64–12.23 kPa. Synergistic effects of the porous network, electrostatic interactions between both amine groups in chitosan and carbon surface with methyl orange (MO) cause the as-fabricated aerogel composites to achieve an extremely high adsorption capacity of 454.13 mg/g and removal efficiency of 92.32 % at initial MO concentration of 500 mg/L. Therefore, the CP-derived carbon/chitosan aerogel composites synthesized from a feasible procedure exhibit their great potential in enhancing the value of coconut waste and dealing with dye-contaminated water pollution by simple and economical adsorption.