bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trapped O2 and the origin of voltage fade in layered Li-rich cathodes
Authors: Marie John-Joseph , House Robert A. , Rees Gregory J. , Robertson Alex W. , Jenkins Max , Chen Jun , Agrestini Stefano , Garcia-Fernandez Mirian , Zhou Ke-Jin , Bruce Peter G. 
Published: March 2024

AbstractOxygen redox cathodes, such as Li1.2Ni0.13Co0.13Mn0.54O2, deliver higher energy densities than those based on transition metal redox alone. However, they commonly exhibit voltage fade, a gradually diminishing discharge voltage on extended cycling. Recent research has shown that, on the first charge, oxidation of O2− ions forms O2 molecules trapped in nano-sized voids within the structure, which can be fully reduced to O2− on the subsequent discharge. Here we show that the loss of O-redox capacity on cycling and therefore voltage fade arises from a combination of a reduction in the reversibility of the O2−/O2 redox process and O2 loss. The closed voids that trap O2 grow on cycling, rendering more of the trapped O2 electrochemically inactive. The size and density of voids leads to cracking of the particles and open voids at the surfaces, releasing O2. Our findings implicate the thermodynamic driving force to form O2 as the root cause of transition metal migration, void formation and consequently voltage fade in Li-rich cathodes.
Digenic inheritance involving a muscle-specific protein kinase and the giant titin protein causes a skeletal muscle myopathy
Authors: Töpf Ana , Cox Dan , Zaharieva Irina T. , Di Leo Valeria , Sarparanta Jaakko , Jonson Per Harald , Sealy Ian M. , Smolnikov Andrei , White Richard J. , Vihola Anna , Savarese Marco , Merteroglu Munise , Wali Neha , Laricchia Kristen M. , Venturini Cristina , Vroling Bas , Stenton Sarah L. , Cummings Beryl B. , Harris Elizabeth , Marini-Bettolo Chiara , Diaz-Manera Jordi , Henderson Matt , Barresi Rita , Duff Jennifer , England Eleina M. , Patrick Jane , Al-Husayni Sundos , Biancalana Valerie , Beggs Alan H. , Bodi Istvan , Bommireddipalli Shobhana , Bönnemann Carsten G. , Cairns Anita , Chiew Mei-Ting , Claeys Kristl G. , Cooper Sandra T. , Davis Mark R. , Donkervoort Sandra , Erasmus Corrie E. , Fassad Mahmoud R. , Genetti Casie A. , Grosmann Carla , Jungbluth Heinz , Kamsteeg Erik-Jan , Lornage Xavière , Löscher Wolfgang N. , Malfatti Edoardo , Manzur Adnan , Martí Pilar , Mongini Tiziana E. , Muelas Nuria , Nishikawa Atsuko , O’Donnell-Luria Anne , Ogonuki Narumi , O’Grady Gina L. , O’Heir Emily , Paquay Stéphanie , Phadke Rahul , Pletcher Beth A. , Romero Norma B. , Schouten Meyke , Shah Snehal , Smuts Izelle , Sznajer Yves , Tasca Giorgio , Taylor Robert W. , Tuite Allysa , Van den Bergh Peter , VanNoy Grace , Voermans Nicol C. , Wanschitz Julia V. , Wraige Elizabeth , Yoshimura Kimihiko , Oates Emily C. , Nakagawa Osamu , Nishino Ichizo , Laporte Jocelyn , Vilchez Juan J. , MacArthur Daniel G. , Sarkozy Anna , Cordell Heather J. , Udd Bjarne , Busch-Nentwich Elisabeth M. , Muntoni Francesco , Straub Volker 
Published: March 2024

AbstractIn digenic inheritance, pathogenic variants in two genes must be inherited together to cause disease. Only very few examples of digenic inheritance have been described in the neuromuscular disease field. Here we show that predicted deleterious variants inSRPK3, encoding the X-linked serine/argenine protein kinase 3, lead to a progressive early onset skeletal muscle myopathy only when in combination with heterozygous variants in theTTNgene. The co-occurrence of predicted deleteriousSRPK3/TTNvariants was not seen among 76,702 healthy male individuals, and statistical modeling strongly supported digenic inheritance as the best-fitting model. Furthermore, double-mutant zebrafish (srpk3−/−;ttn.1+/−) replicated the myopathic phenotype and showed myofibrillar disorganization. Transcriptome data suggest that the interaction ofsrpk3andttn.1in zebrafish occurs at a post-transcriptional level. We propose that digenic inheritance of deleterious changes impacting both the protein kinase SRPK3 and the giant muscle protein titin causes a skeletal myopathy and might serve as a model for other genetic diseases.
Iron dysregulation and inflammatory stress erythropoiesis associates with long-term outcome of COVID-19
Authors: Hanson Aimee L. , Mulè Matthew P. , Ruffieux Hélène , Mescia Federica , Bergamaschi Laura , Pelly Victoria S. , Turner Lorinda , Kotagiri Prasanti ,   Cambridge Institute of Therapeutic Immunology and Infectious Disease–National Institute for Health Research (CITIID–NIHR) COVID BioResource Collaboration, Göttgens Berthold , Hess Christoph , Gleadall Nicholas , Bradley John R. , Nathan James A. , Lyons Paul A. , Drakesmith Hal , Smith Kenneth G. C. 
Published: March 2024

AbstractPersistent symptoms following SARS-CoV-2 infection are increasingly reported, although the drivers of post-acute sequelae (PASC) of COVID-19 are unclear. Here we assessed 214 individuals infected with SARS-CoV-2, with varying disease severity, for one year from COVID-19 symptom onset to determine the early correlates of PASC. A multivariate signature detected beyond two weeks of disease, encompassing unresolving inflammation, anemia, low serum iron, altered iron-homeostasis gene expression and emerging stress erythropoiesis; differentiated those who reported PASC months later, irrespective of COVID-19 severity. A whole-blood heme-metabolism signature, enriched in hospitalized patients at month 1–3 post onset, coincided with pronounced iron-deficient reticulocytosis. Lymphopenia and low numbers of dendritic cells persisted in those with PASC, and single-cell analysis reported iron maldistribution, suggesting monocyte iron loading and increased iron demand in proliferating lymphocytes. Thus, defects in iron homeostasis, dysregulated erythropoiesis and immune dysfunction due to COVID-19 possibly contribute to inefficient oxygen transport, inflammatory disequilibrium and persisting symptomatology, and may be therapeutically tractable.
High resolution climate change observations and projections for the evaluation of heat-related extremes
Authors: Williams Emily , Funk Chris , Peterson Pete , Tuholske Cascade 
Published: March 2024

AbstractThe Climate Hazards Center Coupled Model Intercomparison Project Phase 6 climate projection dataset (CHC-CMIP6) was developed to support the analysis of climate-related hazards, including extreme humid heat and drought conditions, over the recent past and in the near-future. Global daily high resolution (0.05°) grids of the Climate Hazards InfraRed Temperature with Stations temperature product, the Climate Hazards InfraRed Precipitation with Stations precipitation product, and ERA5-derived relative humidity form the basis of the 1983–2016 historical record, from which daily Vapor Pressure Deficits (VPD) and maximum Wet Bulb Globe Temperatures (WBGTmax) were derived. Large CMIP6 ensembles from the Shared Socioeconomic Pathway 2-4.5 and SSP 5-8.5 scenarios were then used to develop high resolution daily 2030 and 2050 ‘delta’ fields. These deltas were used to perturb the historical observations, thereby generating 0.05° 2030 and 2050 projections of daily precipitation, temperature, relative humidity, and derived VPD and WBGTmax. Finally, monthly counts of frequency of extremes for each variable were derived for each time period.
QAL-BP: an augmented Lagrangian quantum approach for bin packing
Authors: Cellini Lorenzo , Macaluso Antonio , Lombardi Michele 
Published: March 2024

AbstractThe bin packing is a well-known NP-Hard problem in the domain of artificial intelligence, posing significant challenges in finding efficient solutions. Conversely, recent advancements in quantum technologies have shown promising potential for achieving substantial computational speedup, particularly in certain problem classes, such as combinatorial optimization. In this study, we introduce QAL-BP, a novel Quadratic Unconstrained Binary Optimization (QUBO) formulation designed specifically for bin packing and suitable for quantum computation. QAL-BP utilizes the Augmented Lagrangian method to incorporate the bin packing constraints into the objective function while also facilitating an analytical estimation of heuristic, but empirically robust, penalty multipliers. This approach leads to a more versatile and generalizable model that eliminates the need for empirically calculating instance-dependent Lagrangian coefficients, a requirement commonly encountered in alternative QUBO formulations for similar problems. To assess the effectiveness of our proposed approach, we conduct experiments on a set of bin packing instances using a real Quantum Annealing device. Additionally, we compare the results with those obtained from two different classical solvers, namely simulated annealing and Gurobi. The experimental findings not only confirm the correctness of the proposed formulation, but also demonstrate the potential of quantum computation in effectively solving the bin packing problem, particularly as more reliable quantum technology becomes available.
Deep learning-based prediction of post-pancreaticoduodenectomy pancreatic fistula
Authors: Lee Woohyung , Park Hyo Jung , Lee Hack-Jin , Song Ki Byung , Hwang Dae Wook , Lee Jae Hoon , Lim Kyongmook , Ko Yousun , Kim Hyoung Jung , Kim Kyung Won , Kim Song Cheol 
Published: March 2024

AbstractPostoperative pancreatic fistula is a life-threatening complication with an unmet need for accurate prediction. This study was aimed to develop preoperative artificial intelligence-based prediction models. Patients who underwent pancreaticoduodenectomy were enrolled and stratified into model development and validation sets by surgery between 2016 and 2017 or in 2018, respectively. Machine learning models based on clinical and body composition data, and deep learning models based on computed tomographic data, were developed, combined by ensemble voting, and final models were selected comparison with earlier model. Among the 1333 participants (training, n = 881; test, n = 452), postoperative pancreatic fistula occurred in 421 (47.8%) and 134 (31.8%) and clinically relevant postoperative pancreatic fistula occurred in 59 (6.7%) and 27 (6.0%) participants in the training and test datasets, respectively. In the test dataset, the area under the receiver operating curve [AUC (95% confidence interval)] of the selected preoperative model for predicting all and clinically relevant postoperative pancreatic fistula was 0.75 (0.71–0.80) and 0.68 (0.58–0.78). The ensemble model showed better predictive performance than the individual ML and DL models.
Assessment of a one-week ketogenic diet on brain glycolytic metabolism and on the status epilepticus stage of a lithium–pilocarpine rat model
Authors: Doyen Matthieu , Lambert Clémentine , Roeder Emilie , Boutley Henri , Chen Bailiang , Pierson Julien , Verger Antoine , Raffo Emmanuel , Karcher Gilles , Marie Pierre-Yves , Maskali Fatiha 
Published: March 2024

AbstractThe ketogenic diet (KD) has been shown to be effective in refractory epilepsy after long-term administration. However, its interference with short-term brain metabolism and its involvement in the early process leading to epilepsy remain poorly understood. This study aimed to assess the effect of a short-term ketogenic diet on cerebral glucose metabolic changes, before and after status epilepticus (SE) in rats, by using [18F]-FDG PET. Thirty-nine rats were subjected to a one-week KD (KD-rats, n = 24) or to a standard diet (SD-rats, n = 15) before the induction of a status epilepticus (SE) by lithium-pilocarpine administrations. Brain [18F]-FDG PET scans were performed before and 4 h after this induction. Morphological MRIs were acquired and used to spatially normalize the PET images which were then analyzed voxel-wisely using a statistical parametric-based method. Twenty-six rats were analyzed (KD-rats, n = 15; SD-rats, n = 11). The 7 days of the KD were associated with significant increases in the plasma β-hydroxybutyrate level, but with an unchanged glycemia. The PET images, recorded after the KD and before SE induction, showed an increased metabolism within sites involved in the appetitive behaviors: hypothalamic areas and periaqueductal gray, whereas no area of decreased metabolism was observed. At the 4th hour following the SE induction, large metabolism increases were observed in the KD- and SD-rats in areas known to be involved in the epileptogenesis process late—i.e., the hippocampus, parahippocampic, thalamic and hypothalamic areas, the periaqueductal gray, and the limbic structures (and in the motor cortex for the KD-rats only). However, no statistically significant difference was observed when comparing SD and KD groups at the 4th hour following the SE induction. A one-week ketogenic diet does not prevent the status epilepticus (SE) and associated metabolic brain abnormalities in the lithium-pilocarpine rat model. Further explorations are needed to determine whether a significant prevention could be achieved by more prolonged ketogenic diets and by testing this diet in less severe experimental models, and moreover, to analyze the diet effects on the later and chronic stages leading to epileptogenesis.
Study on the lignin-derived sp2–sp3 hybrid hard carbon materials and the feasibility for industrial production
Authors: Long Si-Yu , Qin Yan , Liu Jin-Lei , Xian Xue-Quan , Zhou Ling-Qiang , Lv Wen-Da , Tang Pei-Duo , Wang Qin-Yan , Du Qi-Shi 
Published: March 2024

AbstractHard carbon has been widely used in anode of lithium/sodium ion battery, electrode of supercapacitor, and carbon molecular sieve for CO2 capture and hydrogen storage. In this study the lignin derived hard carbon products are investigated, and the conclusions are abstracted as follows. (1) The lignin derived hard carbon products consist of microcrystal units of sp2 graphene fragments, jointed by sp3 carbon atoms and forming sp2–sp3 hybrid hard carbon family. (2) From the lignin precursors to the sp2–sp3 hybrid hard carbon products, most carbon atoms retain their original electron configurations (sp2 or sp3) and keep their composition in lignin. (3) The architectures of lignin-derived hard carbon materials are closely dependent on the forms of their lignin precursors, and could be preformed by different pretreatment techniques. (4) The carbonization of lignin precursors follows the mechanism “carbonization in situ and recombination nearby”. (5) Due to the high carbon ratio and abundant active functional groups in lignin, new activation techniques could be developed for control of pore size and pore volume. In general lignin is an excellent raw material for sp2–sp3 hybrid hard carbon products, a green and sustainable alternative resource for phenolic resin, and industrial production for lignin derived hard carbon products would be feasible.
A PLC-based pomegranate sprout removal device design
Authors: Qiu Liqi , Sun Jingbin , Zhang Xieliang , Sun Qun , Zhao Ying 
Published: March 2024

AbstractAiming at the current low degree of mechanization of pomegranate sprouting tiller pruning in China, all relying on manual pruning, this paper designs a PLC-based pomegranate sprouting tiller removal machine. This machine adopts the identification method of wireless map transmission, the sprouting tiller removal method of multi-cylinder cooperative operation, and the MCGS configuration to realize the interaction between the user and the system, which realizes the displacement and angle compensation of the end-effector under complex conditions to realize the all-around accurate removal of the pomegranate sprouting tiller. The performance test and finite element analysis showed that the device could remove up to 74.62% of sprouting tillers, and the damage rate was as low as 18%. This meets the requirements of pomegranate plantations for the removal of emergent tillers.
A randomised controlled trial investigating the causal role of the medial prefrontal cortex in mediating self-agency during speech monitoring and reality monitoring
Authors: Tan Songyuan , Jia Yingxin , Jariwala Namasvi , Zhang Zoey , Brent Kurtis , Houde John , Nagarajan Srikantan , Subramaniam Karuna 
Published: March 2024

AbstractSelf-agency is the awareness of being the agent of one's own thoughts and actions. Self-agency is essential for interacting with the outside world (reality-monitoring). The medial prefrontal cortex (mPFC) is thought to be one neural correlate of self-agency. We investigated whether mPFC activity can causally modulate self-agency on two different tasks of speech-monitoring and reality-monitoring. The experience of self-agency is thought to result from making reliable predictions about the expected outcomes of one’s own actions. This self-prediction ability is necessary for the encoding and memory retrieval of one’s own thoughts during reality-monitoring to enable accurate judgments of self-agency. This self-prediction ability is also necessary for speech-monitoring where speakers consistently compare auditory feedback (what we hear ourselves say) with what we expect to hear while speaking. In this study, 30 healthy participants are assigned to either 10 Hz repetitive transcranial magnetic stimulation (rTMS) to enhance mPFC excitability (N = 15) or 10 Hz rTMS targeting a distal temporoparietal site (N = 15). High-frequency rTMS to mPFC enhanced self-predictions during speech-monitoring that predicted improved self-agency judgments during reality-monitoring. This is the first study to provide robust evidence for mPFC underlying a causal role in self-agency, that results from the fundamental ability of improving self-predictions across two different tasks.
Nutritional ketosis as treatment for alcohol withdrawal symptoms in female C57BL/6J mice
Authors: Tonetto Simone , Weikop Pia , Thomsen Morgan 
Published: March 2024

AbstractUpon both acute and prolonged alcohol intake, the brain undergoes a metabolic shift associated with increased acetate metabolism and reduced glucose metabolism, which persists during abstinence, putatively leading to energy depletion in the brain. This study evaluates the efficacy of ketogenic treatments to rescue psychiatric and neurochemical alterations during long-term alcohol withdrawal. Female mice were intermittently exposed to alcohol vapor or air for three weeks, during which mice were introduced to either a ketogenic diet (KD), control diet supplemented with ketone ester (KE) or remained on control diet (CD). Withdrawal symptoms were assessed over a period of four weeks followed by re-exposure using several behavioral and biochemical tests. Alcohol-exposed mice fed CD displayed long-lasting depressive-like symptoms measured by saccharin preference and tail suspension, as well as decreased norepinephrine levels and serotonin turnover in the hippocampus. Both KD and KE rescued anhedonia for up to three weeks of abstinence. KD mice showed higher latency to first immobility in the tail suspension test, as well as lower plasma cholesterol levels. Our findings show promising effects of nutritional ketosis in ameliorating alcohol withdrawal symptoms in mice. KD seemed to better rescue these symptoms compared to KE.
Surface and subsurface dispersal of radioactive materials from Fukushima by subpolar gyre and intermediate waters in the North Pacific
Authors: Lee Seung-Tae , Cho Yang-Ki , Jung Jihun , Chae Seunghwa 
Published: March 2024

AbstractRadioactive materials were released into the ocean following the Fukushima Daiichi Nuclear Power Plant accident in 2011. Six years after the accident, the radioactive material concentration was markedly increased in the Okhotsk Intermediate Water (OIW) of the Sea of Okhotsk. This material may have been subjected to southward subsurface dispersal by the North Pacific Intermediate Water (NPIW), which originates from the OIW. The spatiotemporal limitations of available methods have made it challenging to track the dispersal paths of radioactive materials in the North Pacific Subpolar region. Here, we performed a tracer experiment using a three-dimensional numerical model to determine the path of 137Cs from Fukushima to the Sea of Okhotsk via surface subpolar gyre currents and subsurface dispersion by OIW and NPIW. The results showed that the 137Cs concentration in the Sea of Okhotsk increased via the surface current and moved progressively southward via OIW six years after the accident and eastward via OIW and NPIW nine years after the accident, indicating that 137Cs transported by NPIW entered the subtropical region. Based on experiments, this temporal change was mainly caused by ocean currents. Thus, subsurface recirculation of radioactive material via the OIW and NPIW should be considered based on the predicted path and travel time of additional materials released from the power plant.
Dissection of figured wood trait in curly birch (Betula pendula Roth var. carelica (Mercklin) Hämet-Ahti) using high-throughput genotyping
Authors: Gubaev Rim , Karzhaev Dmitry , Grigoreva Elizaveta , Lytkin Kirill , Safronycheva Elizaveta , Volkov Vladimir , Nesterchuk Veronika , Vetchinnikova Lidiia , Zhigunov Anatoly , Potokina Elena 
Published: March 2024

AbstractCurly (Karelian) birch is a special variety of Betula pendula Roth distributed in the northwestern part of Europe. Karelian birch is well-known for its valuable figured curly wood also known as “wooden marble”. The genetic basis underlying curly wood formation has been debated since last century, however, there was no data about loci responsible for the curly wood trait. In the present study, we analyzed two full-sibs populations derived from experimental crosses of curly birches and segregating for the trait. RADseq genotyping was applied to reveal how many loci are involved in ‘curliness’ formation and to search for genetic variants associated with this trait. One single interval on chromosome 10 was detected containing possible candidate genes. InDel marker BpCW1 was suggested for the first time for marker-assisted selection of trees with curly wood at their earliest stages of development.
Optimization strategy of Co3O4 nanoparticles in biomethane production from seaweeds and its potential role in direct electron transfer and reactive oxygen species formation
Authors: Hassaan Mohamed A. , Elkatory Marwa R. , El-Nemr Mohamed A. , Ragab Safaa , El Nemr Ahmed 
Published: March 2024

AbstractIn the present study, three process parameters optimization were assessed as controlling factors for the biogas and biomethane generation from brown algae Cystoceira myrica as the substrate using RSM for the first time. The biomass amount, Co3O4NPs dosage, and digestion time were assessed and optimized by RSM using Box-Behnken design (BBD) to determine their optimum level. BET, FTIR, TGA, XRD, SEM, XPS, and TEM were applied to illustrate the Co3O4NPs. FTIR and XRD analysis established the formation of Co3O4NPs. The kinetic investigation confirmed that the modified model of Gompertz fit the research results satisfactorily, with R2 ranging between 0.989–0.998 and 0.879–0.979 for biogas and biomethane production, respectively. The results recommended that adding Co3O4NPs at doses of 5 mg/L to C. myrica (1.5 g) significantly increases biogas yield (462 mL/g VS) compared to all other treatments. The maximum biomethane generation (96.85 mL/g VS) was obtained with C. myrica at (0 mg/L) of Co3O4NPs. The impacts of Co3O4NPs dosages on biomethane production, direct electron transfer (DIET) and reactive oxygen species (ROS) were also investigated in detail. The techno-economic study results demonstrate the financial benefits of this strategy for the biogas with the greatest net energy content, which was 2.82 kWh with a net profit of 0.60 USD/m3 of the substrate and was produced using Co3O4NPs (5 mg/L).