bluuebunny/crossref_metadata_2025_split huggingface dataset:
The regional treatment of liver metastases from breast cancer
Authors: Schneebaum Schlomo , Walker Michael J. , Young Donn , Farrar William B. , Minton John P. 
Published: February 2007

AbstractTo determine the effect of aggressive regional therapy for liver metastasis from breast cancer, we retrospectively reviewed data on 74 patients identified with liver metastases. Forty had only liver metastases. In this group of 40 patients, 18 were treated with regional therapy only, i.e., surgical resection and/or regional chemotherapy via hepatic artery or portal vein catheters whereas 22 patients had systemic chemotherapy. The two groups were comparable. The regional chemotherapy regimen was 5‐FU, Adriamycin, methotrexate, and cytoxan. Median survival (27 months) for those patients treated with regional therapy (N = 18) was significantly longer than for those (N = 22) treated with systemic therapy (5 months) (P = 0.001). Only 45% of the regional treatment group failed in the liver. Our data, although retrospective and selective, suggest that certain subgroups of breast cancer patients with metastatic liver disease may benefit from aggressive regional therapy. © Wiley‐Liss, Inc.
Integrated approach to the management of patients with advanced germ cell tumors of the testis
Authors: Ravi R. , Rao R. Ranga , Shanta V. 
Published: February 2007

AbstractBetween 1985 and 1991, 63 patients with disseminated germ cell tumors of the testis were treated with initial cisplatin based combination chemotherapy. Complete response was seen in 38% of patients. Adjunctive surgical resection of residual disease was carried out in 26 patients (41%), including the use of intraoperative radiation therapy in two patients with seminoma. Furthermore, two other patients with seminoma and residual mass underwentretroperitoneal irradiation. Salvage chemotherapy was administered to five patients with progressive disease, and only one of these could be salvaged with adjunctive surgery. A disease‐free state was achieved in 75% of patients at a mean follow‐up period of 30 months. © Wiley‐Liss, Inc.
The effect of sulindac on colon polyps: Circumvention of a transformed phenotype—A hypothesis
Authors: Waddell William R. 
Published: February 2007

AbstractSulindac suppresses the growth of colon polyps in Gardner syndrome and familial adenomatous polyposis. The mechanism of action is not known. The problems are to ascertain the significance of high prostaglandin concentrations in transformed cells, colon polyps and cancers and to explain how sulindac restores normal growth patterns. A few clinical observations and an abundance of experimental data can be integrated to produce a reasonable model based on current biochemical and physiologic concepts. A fundamental defect in the formation of colon polyps is mutation of the APC (adenomatous polyposis coli) gene that leads to inadequate suppression of proliferation. There is high PGE2 content in colon polyps and cancers, presumably the result of stimulation by protein kinase C (PKC). In small quantities it stimulates cyclic AMP production but with persistent high concentrations it desensitizes and down‐regulates specific PG receptors and inactivates adenylate cyclase, cAMP synthesis, and the cAMP‐dependent mechanism for control of proliferation. The PKC pathway is thereby unopposed. It is hypothesized that restriction of PG synthesis by sulindac is accompanied by resensitization of PG receptors, and reactivation of the cAMP‐dependent pathway for control of cell growth. It is further postulated that restoration of cAMP synthesis and protein kinase A activity converts a functionally inadequate mutant APC suppressor gene to one sufficient to inhibit colon polyp formation. © Wiley‐Liss, Inc.
Rapidly growing thyroid carcinoma during pregnancy
Authors: Kobayashi Kaoru , Tanaka Yoshiyuki , Ishiguro Shingo , Mori Tohru 
Published: February 2007

AbstractWe experienced two cases of papillary carcinoma of the thyroid during pregnancy. The thyroid carcinomas grew rapidly in early pregnancy. We speculate that human chorionic gonadotropin plays an important role in the rapid growth of thyroid carcinoma during pregnancy. © Wiley‐Liss, Inc.
Melanotic neuroectodermal tumor of infancy: Report of a case with ganglionic differentiation
Authors: Shah Rajesh V. , Jambhekar Nirmala A. , Rana Durgesh N. , Raje Noopur S. , Albuqurque Kevin V. , Mistry Rajesh C. , Desai Prafulla B. , Advani Suresh H. 
Published: February 2007

AbstractMelanotic neuroectodermal tumor of infancy (MNTI) is a rare but well‐documented lesion of neuroectodermal derivation. Maturation of the neural elements has been reported only occasionally. We report a case of MNTI of the maxilla showing maturation of neural elements to ganglionic cells. © Wiley‐Liss, Inc.
Granulosa cell tumor of the ovary: A study of 18 cases
Authors: Piura Benjamin , Nemet Dan , Yanai‐Inbar Ilana , Cohen Yoram , Glezerman Marek 
Published: February 2007

AbstractIn a study of 18 patients diagnosed with ovarian granulosa cell tumor between 1961 and 1992, clinical and pathologic findings were evaluated. Of the 18 patients, 15 (83.3%) were diagnosed in Stage I and three (16.7%) in Stage III or IV. Six patients (33.3%) underwent conservative surgery and in 12 (66.7%) total abdominal hysterectomy and bilateral salpingo‐oophorectomy was performed. At follow‐up three patients (16.6%) had died of disease, three, 16 and 288 months, respectively, after initial surgery. The actuarial 5‐year survival rate for Stage I was 100%, while that for Stages III and IV combined was 33.3% (P < 0.05). It is concluded that for patients with Stage IA, unilateral oophorectomy seems to be adequate treatment and for those with more than Stage IA, surgery should include total abdominal hysterectomy and bilateral salpingo‐oophorectomy. Postoperative adjuvant chemotherapy is advocated for patients in whom spread of tumor beyond the ovaries has occurred. © Wiley‐Liss, Inc.
Analysis of multiple primary cancers in a single institution
Authors: Santos Mary C. , Gardner Bernard , Feldman Joseph 
Published: February 2007

AbstractRecords of 120 patients with two and 16 with three primary cancers were evaluated. There were 49 males and 71 females among the double primaries with ages ranging from 27–102 years (average 68 years at the time of fist cancer). Of 35 breast cancer patients 16 new primaries developed in the opposite breast and other sites including four colon, three lung, and three endometrium. Of 20 colon cancer patients second primaries occurred in 11 sites most commonly colon (four) and lung (three). The frequency of second primaries may be skewed by the fact that patients with lethal cancers did not live long enough to develop them. This is borne out by the fact that 74 of the 120 patients were alive at the time of the study, implying a highly favorable group of patients. The interval between primaries was longer in females than males (P < 0.05) and this difference disappeared when breast and endometrial cancer were eliminated. When age was evaluate as a factor younger patients appeared to have a longer interval between primaries (P = 0.24) and this became significant for breast patients under age 55 years (91 months vs. 36 months) (P < 0.05). The stage of the second breast primary bore no relationship to the interval between primaries. © Wiley‐Liss, Inc.
Expression of proliferating cell nuclear antigen in Wilms' tumors and other pediatric renal tumors: The correlation between histologic classification and proliferative activity
Authors: Nagoshi Makoto , Tsuneyoshi Masazumi 
Published: February 2007

AbstractIn order to estimate the proliferative activities in each prognosis predicting histologic type immunohistochemical studies for proliferating cell nuclear antigen (PCNA) have been performed on 27 pediatric renal tumors using formalin‐fixed paraffin‐embedded specimens. Image analyses determined the percentage of positive areas for PCNA, which were then represented in the PCNA score. The PCNA scores of nephroblastomas without anaplasia roughly correlated with the S phase fractions obtained by flow cytometry. The PCNA scores for each tumor were as follows; the renal specimens for the control study (n = 10, a mean ±SSD of 8.04 ± 3.59%); the nephroblastomas without anaplasia (n = 15, 27.70 ± 7.59%); the nephroblastomas with anaplasia (n = 3, 36.89 ± 1.17%); the sarcomatous renal tumors (n = 5, 27.75 ± 5.02); the renal cell carcinomas (n = 2, 28.31 ± 0.86%), a congenital mesoblastic nephroma and a juxtaglomerular cell tumor (10.05 and 10.80%, respectively). The PCNA scores of the pediatric renal tumors correlated with neither the outcome of the patients nor the histologic groups in predicting the prognosis for such pediatric renal tumors. © Wiley‐Liss, Inc.
Transient mutism following posterior fossa surgery in children
Authors: Al‐Jarallah Ahmed , Cook Jay David , Gascon Generoso , Kanaan Imaduddin , Sigueira Edir 
Published: February 2007

AbstractWe report 3 patients, ages 5, 9 and 13 years, with mutism following posterior fossa surgery (PFS). All presented with headache of 10–180 days duration, excellent premorbid learning performance and paucity of neurologic signs. Radiographic studies demonstrated large posterior fossa tumor occupying the fourth ventricle, and hydrocephalus, leading to gross total resection of the tumor. Within 24–48 hr, all patients were mute. None had problems with swallowing and coughing. AH were able to nod “yes or no,” follow commands, point to body parts, and make their wants known by gestures. Jaw, gag, snout and palmomental reflexes were normal. CT scan and MRI Brain showed no cerebral hemispheric lesions. All children regained speech although dysarthric, within 5–12 weeks. Twenty‐two previously reported cases are similar to ours. We conclude that this post‐surgical mutism syndrome is unique and must be differentiated from aphemia, Broca's aphasia, hysterical mutism and elective mutism. The cerebellum, in a way not yet understood, does play a role in speech production. © Wiley‐Liss, Inc.
Adrenal adenocarcinoma: A review of 53 cases
Authors: Zografos George C. , Driscoll Deborah L. , Karakousis Constantine P. , Huben Robert P. 
Published: February 2007

AbstractProblem: Fifty‐three patients (30 men, 23 women) with histologically proven adrenal carcinoma were reviewed. Nineteen (36%) had endocrine manifestations from functioning tumors. Arteriography was positive in 95% (19/20), CT scan in 94% (17/18), and ultrasound in 92% (12/13). Seventy‐six percent of the patients, at the time of diagnosis, were stage III and IV. Most common metastatic sites were the liver, lymph nodes, bone, and lungs. Local recurrence developed in 39% of cases (15/38).Method: Forty‐one patients underwent an operation. Complete surgical removal of all gross tumor was achieved in 24 patients.Result: The overall median survival time was 8 months, and the estimated 5‐year survival rate 19%. There were significant differences in survival between the various stages (P= 0.01) and between the group of patients who underwent complete excision of the tumor and those with incomplete resection (P= 0.002).Conclusions: Complete surgical excision offers the best prospect for long‐term survival in localized adrenal carcinoma. © Wiley‐Liss, Inc.
Reconstruction of chest wall defects following extirpative surgery
Authors: Savant Dhairyasheel N. , Patel Snehal C. , Bokil Kamlesh P. , Bhathena Hosi M. , Kavarana Naozer M. , Vyas Jeetendra J. 
Published: February 2007

AbstractReconstructive procedures following chest wall resection pose a special surgical challenge. With modern surgical technique, a wide range of reconstructive options are at the surgeon's disposal and, hence it is imperative that the appropriate procedure be selected in a given patient. A total of 64 patients underwent resection of malignant chest wall tumors at the Tata Memorial Hospital. The technique of preference at our institution for reconstruction of full‐thickness chest wall defects uses a combination of autogenous fascia lata and Marlexmesh. We present our experience with chest wall reconstruction following extirpative surgery in these patients. © Wiley‐Liss, Inc.
Central venous brachial catheter (P.A.S. port TM) and catheter scanning system (cath‐finder TM)
Authors: Carré M. Carmen , Vega José Manuel López , Carles Joan , Lizón José , Villar Anselmo , Lera Santiago Alonso , Alastrue Antonio , Rull Miguel , van der Hossladt C. , Aguiló Javier , Díaz‐Rubio Eduardo , Rosell Rafael 
Published: February 2007

AbstractTo assess the effectiveness and safety of an implanted portal with a central venous brachial implanted catheter, P.A.S. Port TM(P–P), and the accuracy of its Cath Finder TM tracking system (C–F), (Pharmacia Deltec) vs. radiology, a phase II multicentric study was designed.The catheter was implanted in 53 oncologic patients treated with chemotherapy and the performance of the catheter was evaluated for 3 months. No problems arose during the implantation in 77% of the cases and in all cases radiologic location of the catheter tip coincided with the C–F. We can conclude that P–P is easy to implant and to maintain in the arm and that it is well tolerated by the patients. C–F is an accurate and reliable system for locating the catheter tip. The use of both systems is an attractive alternative to the standard ones. © Wiley‐Liss, Inc.
Growth pattern and prognosis of gastric cancer invading the subserosa
Authors: Maehara Yoshihiko , Oshiro Tatsuo , Adachi Yosuke , Ohno Shinji , Akazawa Kohei , Sugimachi Keizo 
Published: February 2007

AbstractGastric cancer invading the subserosa with infiltrative growth was classified as part of the serosal invasion group and named prognostic serosal invasion positive [ps(+)] histologically.We analyzed clinicopathological features and prognosis of 166 Japanese patients with gastric cancer invading the subserosa, according to the growth pattern. All patients were treated in the Department of Surgery II, Kyushu University. Patients with infiltrative growth (ssγ) were younger and their tumors were frequently undifferentiated compared to findings in those with noninfiltrative growth: expansive (ssα) and intermediate growth (ssß). There was no difference in any other clinicopathological characteristic between those with infiltrative and noninfiltrative growth tumors. The 10‐year survival rate was 66.7% for the infiltrative type and 54.2% for the noninfiltrative type, with no statistically significant difference. Lymph node metastasis, curative resection, and extended lymph node dissection, but not growth pattern, proved to be independent prognostic factors, as determined by multivariate analysis.Our findings suggest that it is not the growth pattern which affects the prognosis of ss cancers. Extensive lymph node dissection should be done when lymph node metastasis is present. © Wiley‐Liss, Inc.
Prognostic significance of in vitro thymidine uptake in patients with colorectal carcinoma
Authors: Tanigawa Nobuhiko , Masuda Yasuhiko , Muraoka Ryusuke , Tanaka Takeo 
Published: February 2007

AbstractIn 127 patients with colorectal carcinoma, we measured thymidine uptake by tumor cells cultured in a semisolid medium and compared the influence of various parameters on survival by univariate and multivariate analysis.Fifty‐four of the 127 carcinomas (42.5%) incorporated >1,000 cpm of tritiated thymidine per culture dish and were designated as the high‐uptake group, while the other tumors (57.5%, 73/127) were designated as the low‐uptake group. There was no significant correlation between high or low thymidine uptake and most of the clinicopathological characteristics of the patients. Patients in the high‐uptake had a poor prognosis and a 7‐year survival rate of 32.6%, which was significantly different from the rate of 69.3% in the low‐uptake group (P< 0.0005). Multivariate analysis showed that thymidine uptake was one of the variables strongly associated with survival in our study population.Thus, it is concluded that thymidine uptake by tumor cells has a high capacity of predicting prognosis, independent of its relationship to other variables. Furthermore, it seems to us that thymidine uptake can help in selecting those patients with colorectal carcinoma who are most likely to benefit from perioperative adjuvant therapy. © Wiley‐Liss, Inc.
Adoptive cellular therapy of human breast and colorectal tumor targets using ex vivo activated memory T lymphocytes with potentiation by cis‐diamminedichloroplatinum(II)
Authors: Gold Jay E. , Bleiweiss Ira J. , Goldfarb Alisan B. , Bauer Joel J. , Gelernt Irwin M. , Schwartz Myron E. , Reiner Mark A. , Miller Charles M. , Weiss Marshall F. , Brower Steven T. , Masters Ted R. , Osband Michael E. 
Published: February 2007

AbstractAutolymphocyte therapy (ALT) is adoptive cellular therapy of cancer using ex vivo activation of autologous peripheral blood lymphocytes (PBL). Memory T cells are the principal effector population in ALT, with in vivo activity in patients with metastatic renal cell carcinoma (RCC) and melanoma, and ex vivo cytotoxicity against autologous tumor targets. However, the noncytolytic lymphocyte portion of ex vivo‐activated memory T cells (ALT cells) may also contribute as antitumor effectors. Pre‐treatment of murine and human tumor cells ex vivo with chemotherapeutic agents can enhance their susceptibility to antitumor lymphocytes ex vivo and in vivo. To determine whether cis‐diamminedichloroplatinum(II) (DDP) could enhance ex vivo antitumor effects of ALT cells by immuno‐modulation, human breast and colorectal carcinoma target cells were derived from both primary and metastatic surgical specimens and incubated in complete medium (CM) with DDP or in CM alone (control group). Viability of each group was confirmed by trypan blue—dye exclusion test. ALT cells were prepared from autologous PBL at surgery. Primary and metastatic tumor cells from each group were used as targets for ALT cells and levels of interferon‐γ (IFN‐γ) release were measured as a determination of antitumor effect and recognition. Primary tumor target cells incubated in DDP showed enhanced antitumor effects and recognition by autologous ALT cells, as measured by the IFN‐γ assay compared to non‐DDP‐treated controls. Metastatic autologous tumor target cells demonstrated less IFN‐γ release than did the primary targets, although this was enhanced by pre‐treating metastatic tumor targets with DDP. ALT cells demonstrated minimal IFN‐γ release when incubated with allogeneic tumor targets. These data suggest that autotumor recognition of metastatic tumor targets is comparable to that of primary lesions following ex vivo pretreatment of metastatic cells with nonlethal doses of certain chemotherapeutic agents. DDP may somehow alter the physical properties of target cells, rendering them susceptible to immune‐mediated attack and the combination of ALT and DDP may lead to increased therapeutic efficacy in patients with metastatic breast and colon cancer. © Wiley‐Liss, Inc.
Multidisciplinary treatment of biliary tract cancers
Authors: Kraybill William G. , Lee Henry , Picus Joel , Ramachandran Ganeshan , Lopez Marvin J. , Kucik Nancy , Myerson Robert J. 
Published: February 2007

AbstractNinety‐six patients referred for radiation therapy to Washington University affiliated institutions with tumors of the extrahepatic biliary tree form the basis of this report. Patients were examined with regard to demographic factors, tumor primary site, presenting symptoms, methods of diagnosis, and methods of management. The median survival of all 96 patients in this series was 11 months. There was no significant difference between patients with gallbladder cancer and patients with cancer of the biliary ductal system. There was a statistically significant improvement in survival in those patients undergoing resection as management or as a component of the management of their tumors (P= 0.02). Patients receiving >4,000 cGy of radiation therapy had an improved survival compared to those patients receiving ≤4,000 cGy of radiation therapy (P= 0.003). While surgical resection improved survival for those patients undergoing removal of all gross tumor, this effect was noted especially in patients with gallbladder cancer. © Wiley‐Liss, Inc.
Digital rectal examination, serum prostate specific antigen, and prostatic ultrasound: How effective is this diagnostic triad?
Authors: Haid Max , Rabin David , King Karen M. , Feinstein Charles M. , Janson Kenneth L. , Levine Stanley R. , Mutchnik David L. , Lambiase Elyse A. , Bradley Richard 
Published: February 2007

AbstractNinety‐nine of 105 consecutive men who underwent transrectal prostatic ultrasound (TRUS) at Highland Park Hospital had the results correlated with digital rectal examination (DRE), serum prostate specific antigen (PSA), and biopsy results. Ninety‐six cases had evaluable ultrasound studies. Thirty‐two of the 99 who underwent biopsy had primary carcinoma of the prostate. Prostate volume, predicted PSA, a ratio of observed/predicted PSA, and Gleason score were examined. There was no correlation between age and prostate volume, volume and the presence of carcinoma, or PSA and Gleason score. Thirty‐one point six percent of the abnormal DREs, 36.6% of the abnormal TRUSs, and 40.6% of the elevated PSAs occurred in men with prostatic carcinoma (PCa). If PSA was normal (less than or equal to 4.0 ng/ml) and either DRE or TRUS was abnormal, then the risk of carcinoma was 2.9%. If PSA was elevated, regardless of the other two tests, the risk of finding PCa was at least 38%. If all three tests were abnormal, the risk of carcinoma was 38% in our series and 68% in a meta‐analysis. Many men with PSA values between 4 and 10 ng/ml have benign biopsies. However, close future follow‐up with consideration of repeat biopsy should be strongly considered. © 1994 Wiley‐Liss, Inc.
P53 alteration correlates with negative ER, negative PGR, and high histologic grade in breast cancer
Authors: Sasa Mitsunori , Kondo Kazuya , Komaki Kansei , Morimoto Tadaoki , Monden Yasumasa 
Published: February 2007

AbstractSeventy tumors of invasive ductal carcinoma of the breast were examined for p53 alteration by the RT‐PCR‐SSCP method. Sixty‐five samples (92.9%) were investigated in the regions of codons 101–200 and 201–300. In total, 16 samples (24.6%) showed p53 gene alteration. We found that p53 gene alteration showed a correlation with (1) a negative ER status, (2) a negative PgR status, and (3) a high histologic grade (especially numerous mitotic figures) of the tumor. However, we found no correlation between p53 gene alteration and the lymph node status or clinical stage. Thus, p53 gene alteration in breast cancer may occur in highly malignant breast cancer other than advanced clinical stage cancer or node‐positive cancer. © 1994 Wiley‐Liss, Inc.
Serum CA 125 concentrations in patients with benign ovarian tumours
Authors: Buamah Paul K. , Skillen Andrew W. 
Published: February 2007

AbstractSerum CA 125 concentrations have been measured in 115 patients with histologically confirmed nonmalignant pelvic disease, that is, serous cystadenoma (n = 56), mucinous cystadenoma (n = 14), fibroma (n = 33), thecoma (n = 8), and Brenner tumour (n = 4). Increased CA 125 concentrations (> 35 KU/L) were found in 14 patients, with a range of 46–891 KU/L, a mean of 205 KU/L, and a median of 97 KU/L. The highest values were found in patients with ascites. Serial measurements in one patient showed a fall in the 2 days immediately after surgery, over the next 3 days showing a two‐ to three‐fold increase, followed by a slow return to normal over the next 7 weeks. Elevated CA 125 levels may not indicate ovarian malignancy and do not differentiate between benign and malignant pelvic masses. © 1994 Wiley‐Liss, Inc.