bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adaptation of microglomerular complexes in the honeybee mushroom body lip to manipulations of behavioral maturation and sensory experience
Authors: Krofczik Sabine , Khojasteh Uldus , de Ibarra Natalie Hempel , Menzel Randolf 
Published: April 2008

AbstractWorker honeybees proceed through a sequence of tasks, passing from hive and guard duties to foraging activities. The underlying neuronal changes accompanying and possibly mediating these behavioral transitions are not well understood. We studied changes in the microglomerular organization of the mushroom bodies, a brain region involved in sensory integration, learning, and memory, during adult maturation. We visualized the MB lips' microglomerular organization by applying double labeling of presynaptic projection neuron boutons and postsynaptic Kenyon cell spines, which form microglomerular complexes. Their number and density, as well as the bouton volume, were measured using 3D‐based techniques. Our results show that the number of microglomerular complexes and the bouton volumes increased during maturation, independent of environmental conditions. In contrast, manipulations of behavior and sensory experience caused a decrease in the number of microglomerular complexes, but an increase in bouton volume. This may indicate an outgrowth of synaptic connections within the MB lips during honeybee maturation. Moreover, manipulations of behavioral and sensory experience led to adaptive changes, which indicate that the microglomerular organization of the MB lips is not static and determined by maturation, but rather that their organization is plastic, enabling the brain to retain its synaptic efficacy. © 2008 Wiley Periodicals, Inc. Develop Neurobiol, 2008.
Selective expansion of memory CD4+ T cells by mitogenic human CD28 generates inflammatory cytokines and regulatory T cells
Authors: Singh Manisha , Basu Sreemanti , Camell Christina , Couturier Jacob , Nudelman Rodolfo J. , Medina Miguel A. , Rodgers John R. , Lewis Dorothy E. 
Published: April 2008

AbstractCostimulatory signals are important for development of effector and regulatory T cells. In this case, CD28 signaling is usually considered inert in the absence of signaling through the TCR. By contrast, mitogenic rat CD28 mAb reportedly expand regulatory T cells without TCR stimulation. We found that a commercially available human CD28 mAb (ANC28) stimulated PBMC without TCR co‐ligation or cross‐linking; ANC28 selectively expanded CD4+CD25+FOXP3– (Teff) and CD4+CD25+FOXP3+ (Treg) cells. ANC28 stimulated the CD45RO+ CD4+ (memory) population, whereas CD45RA+CD4+ (naive) cells did not respond. ANC28 also induced inflammatory cytokines. Treg induced by ANC28 retain the Treg phenotype longer than costimulated Treg. Treg induced by ANC28 suppressed CD25– T cells through a contact‐dependent mechanism. Purity influenced the response of CD4+CD25+ cells because bead‐purified CD4+CD25+ cells (85–90% pure) responded strongly to ANC28, whereas 98% pure FACS‐sorted CD4+CD25bright (Treg) did not respond. Purified CD4+CD25int cells responded similarly to the bead‐purified CD4+CD25+ cells. Thus, pre‐activated CD4+ T cells (CD25int) respond to ANC28 rather than Treg (CD25bright). The ability of ANC28 to expand both effectors producing inflammatory cytokines as well as suppressive regulatory T cells might be useful for ex vivo expansion of therapeutic T cells.
Features of TAP‐independent MHC class I ligands revealed by quantitative mass spectrometry
Authors: Weinzierl Andreas O. , Rudolf Despina , Hillen Nina , Tenzer Stefan , van Endert Peter , Schild Hansjörg , Rammensee Hans‐Georg , Stevanović Stefan 
Published: April 2008

AbstractTAP is responsible for transferring cytosolic peptides into the ER, where they can be loaded onto MHC molecules. Deletion of TAP results in a drastic reduction of MHC class I surface expression and alters the presented peptide pattern. This key molecule in antigen processing is tackled by several viruses and lost in some tumors, rendering the altered cells less vulnerable to T cell‐based immune surveillance. Using the TAP‐deficient cell line LCL721.174 and its TAP‐expressing progenitor cell line LCL721.45, we identified and quantified more than 160 HLA ligands, 50 of which were presented TAP‐independently. Peptides which were predominantly presented on the TAP‐deficient LCL721.174 cell line had a decreased MHC binding affinity according to their SYFPEITHI and BIMAS score. About half of the identified TAP‐independently presented peptides were not derived from signal sequences and may partly be generated by the proteasome. Furthermore, we have excluded the possibility that differences in HLA ligand presentation between LCL721.45 and LCL721.174 were due to varying expression of the source proteins or due to changes in the antigen loading complex. Features of peptides presented independently of TAP as well as proteasomal contribution to their generation provide an insight into basic immunological mechanisms.
How Well Should the Active Site and the Specific Recognition Be Defined for Proficient Catalysis? – Effective and Cooperative Polyphenol/Catechol Oxidation and Oxidative DNA Cleavage by a Copper(II)‐Binding and H‐Bonding Copolymer
Authors: Lykourinou Vasiliki , Hanafy Ahmed I. , da Silva Giordano F. Z. , Bisht Kirpal S. , Larsen Randy W. , Livingston Brian T. , Angerhofer Alexander , Ming Li‐June 
Published: April 2008

AbstractDespite the mainly inhomogeneous and unstructured nature of linear polymers, the CuIIcomplex of a vinylpyridine‐acrylamide copolymer exhibits very efficient 2‐electron catalysis toward the oxidation of catechol and derivatives to form quinones with and without 80 mM(0.27 %) H2O2, showing remarkable (0.114–2.67) × 105and (2.83–9.60) × 104‐fold rate enhancements, respectively, in terms of first‐order rate constant relative to auto‐oxidation of the substrates in an aqueous environment under mild conditions. Metal‐binding profiles suggestthe presence of cooperativityin the catalysis. The oxidation catalysis is inhibited by the di‐copper tyrosinase specific kojic acid. Moreover, electron paramagnetic resonance spectra reveal magnetic interaction of the CuIIions. On the basis of the results, the catalysis by this CuII‐polymer seems to be consistent with the mechanism of type‐3 di‐copper oxidases. This complex also shows effective single‐ and double‐stranded DNA cleavage in the presence of 1.0 % H2O2. These studies suggest this CuII‐polymer complex can serve as a unique “chemical nuclease” and a versatile chemical system for further exploration of Cu–oxygen chemistry. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Palladium‐Catalysed Direct C‐H Activation/Arylation of Heteroaromatics: An Environmentally Attractive Access to Bi‐ or Polydentate Ligands
Authors: Derridj Fazia , Gottumukkala Aditya L. , Djebbar Safia , Doucet Henri 
Published: April 2008

AbstractBi‐ or polydentate ligands based on heterocycles can be easily prepared by palladium‐catalysed C–H bond activation of heteroaromatics followed by heteroarylation with heteroaryl bromides. A variety of heteroaromatics such as furans, thiophenes, pyridines, thiazoles or oxazole derivatives have been employed and moderate to good yields were generally obtained using the air‐stable complex [PdCl(dppb)(C3H5)] as catalyst. A range of functions such as acetyl, formyl, ester or nitrile on the heteroaromatics is tolerated.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Nucleophilic Additions to Cyclic Nitrones en Route to Iminocyclitols – Total Syntheses of DMDP, 6‐deoxy‐DMDP, DAB‐1, CYB‐3, Nectrisine, and Radicamine B
Authors: Merino Pedro , Delso Ignacio , Tejero Tomás , Cardona Francesca , Marradi Marco , Faggi Enrico , Parmeggiani Camilla , Goti Andrea 
Published: April 2008

AbstractHighly diastereoselective nucleophilic additions to cyclic nitrones derived from L‐malic acid and D‐arabinose have been used for the construction of enantiomerically pure polyhydroxylated pyrrolidines. The synthetic strategy adopted was based on an oxidation/reduction protocol involving hydroxylamine/nitrone pairs and demonstrates the use of reagent‐ and substrate‐derived stereocontrol. In most cases reactions took place with total diastereoselectivity and in quantitative yield, with no purification being necessary. By this strategy, 2‐(hydroxymethyl)‐, 2‐(aminomethyl)‐, and 2‐aryl‐substituted polyhydroxylated pyrrolidines have been prepared with abundant configurational diversity. The use of appropriate substrates and reagents allowed for approaches to DMDP, 6‐deoxy‐DMDP, DAB‐1, CYB‐3, nectrisine and radicamine B. Several analogues of these compounds with inverted configuration at one or more stereocenters were also prepared.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Broad Functionalization of Deep‐Cavity Cavitands by Directed ortho Metalation
Authors: Srinivasan Kannupal , Laughrey Zachary R. , Gibb Bruce C. 
Published: April 2008

AbstractThe endo‐ and exo‐rim positions of deep‐cavity cavitand 1 were functionalized by directed ortho metalation (DoM) procedures. A range of electrophilic quenchers led to hosts with ester, phenol and thioether functionality. In each case, a combination of host pre‐organization and reaction control resulted in far fewer products than the theoretical sixty‐nine. In addition to the nature of the lithiate, functionalization patterns were also dependent on the electrophile, with a general trend that the non‐carbon electrophiles examined gave higher degrees of substitution. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
First Synthesis of 9,10‐Dimethoxy‐2‐methyl‐1,4‐anthraquinone: A Naturally Occurring Unusual Anthraquinone
Authors: Mal Dipakranjan , Ray Sutapa 
Published: April 2008

AbstractThe synthesis of 9,10‐dimethoxy‐2‐methyl‐1,4‐anthraquinone, an unusual quinone, was achieved in five steps from p‐benzoquinone. A Kochi–Anderson radical methylation features as the key step in the synthesis. The chemistry of a cyclopropa‐1,4‐anthracenedione is also described. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
A Chiral “Frozen” Hydrogen Bonding in C4‐Symmetric Inherently Chiral Resorcin[4]arenes: NMR, X‐ray, Circular Dichroism, and Theoretical Study
Authors: Kuberski Bogumił , Pecul Magdalena , Szumna Agnieszka 
Published: April 2008

AbstractChiral C4‐symmetric resorcinarenes, substituted with l‐amino acid derivatives at upper rims, were synthesized by the modified Mannich reaction and subsequent N‐substitution reactions. Compounds of that type (5a–e) can exist in two relatively stable inherently chiral C4‐symmetric conformations, (M) and (P), stabilized by the formation of seams of hydrogen bonds. However, because of diastereomeric preferences the amino acid substituted resorcinarenes exhibit considerable diastereomeric excesses for the induced conformational inherent chirality (up to ≥95 %). The relatively slow exchange allowed the determination of the directions of the hydrogen bond ring closures through the combined application of NMR (ROESY) and X‐ray analysis. It was also possible to correlate the absolute conformation with the sign of the Cotton effects observed for the transitions within the resorcinol chromophore in the CD spectra (solution and solid state). The ab initio calculations (TDDFT/B3LYP/DZVP and TDDFT/CAMB3LYP/6‐31++G*) for model compounds showed that the chiral arrangement of the hydrogen bonding in resorcinarenes can produce substantial CD effects, which are amplified by exciton coupling. However, it was also shown that the neighboring urea, amide, or phenyl groups have crucial effects on the direction of electric transition dipoles and, as the result, on the signs of the exciton‐coupled bands.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
“When passion breeds justice”: procedural fairness effects as a function of authority's passion
Authors: De Cremer David , den Ouden Nathalie 
Published: April 2008

AbstractThe present research examined how procedural fairness predicts negative emotions and withdrawal behavior as a function of authority's display of passion. A first study revealed that reinforcing the concept of passion made the concept of justice and fairness more accessible to participants, as such suggesting that authority passion should make people focus more on procedural fairness information. Corroborating this line of reasoning, a scenario experiment and a laboratory experiment thereafter yielded consistent evidence that the effects of procedural fairness (i.e., voice vs. no voice) were stronger on negative emotions and willingness to withdraw when the authority was passionate relative to not being passionate. In addition, the results of both studies also revealed that negative emotions mediated the effect of procedural fairness on withdrawal, but only so when the authority was passionate (i.e., mediated moderation). It is concluded that more research is needed focusing on the interactions between different authority styles/characteristics and procedural fairness effects. Copyright © 2008 John Wiley & Sons, Ltd.
Dynamic flood modeling: combining Hurst and Gumbel's approach
Authors: Charpentier Arthur , Sibaï David 
Published: April 2008

AbstractWhen working on river floods—annual river levels maxima—, two approaches are usually considered: one inspired from Emil Gumbel where annual maxima are supposed to be i.i.d. and distributed according to Gumbel's distribution, and one inspired from Edwin Hurst where annual maxima are strongly dependent, and exhibit long range memory. This paper tries to solve this apparent paradox by deriving a dynamic model inspired from financial models, which does not take into account annual maxima only but also threshold exceedances. It studies the implications of such a paradox in terms of return period—a notion valid as long as the data are i.i.d—and of extremal events. Copyright © 2008 John Wiley & Sons, Ltd.
Age and origin of Mississippian lydites: examples from the Pyrénées, southern France
Authors: Randon Carine , Caridroit Martial 
Published: April 2008

AbstractMississippian biogenic siliceous deposits (known as ‘lydites’ or ‘lydian rocks’) intercalated within limestone successions are studied to characterize the signature of this ‘siliceous period’ and its significance, particularly in the Hercynian history of Europe. Therefore, a multidisciplinary approach was conducted, using analysis of conodont faunas, lithologic and microfacies analyses, and the study of inorganic geochemistry, from outcrops in the French Pyrénées. Biostratigraphical study of conodont faunas has established the age of the lydites, as occurring between the lower crenulata and anchoralis‐latus zones. The sedimentological study shows that the sediments were deposited in a deep‐water shelf environment. The lithological succession shows a gradual deepening prior to the siliceous sedimentation. However, it appears that the radiolarites have not been deposited in a deeper water basin, but in a more proximal environment, on an external continental shelf, at a depth of less than 300 m. Analysis of major and trace elements does not show particular trends and there is no discernible change in the ocean water chemistry to explain the change of sediment type. However, the disappearance of limestone deposits and the formation of lydites are interpreted as a combination of several factors including a transgression that changes the oceanic circulation, and eutrophication linked to the circulation of nutrient‐rich cold currents. Copyright © 2007 John Wiley & Sons, Ltd.
Is therapy with calcium and vitamin D and parathyroid autotransplantation useful in total thyroidectomy for preventing hypocalcemia?
Authors: Abboud Bassam , Sleilaty Ghassan , Zeineddine Salam , Braidy Carla , Aouad Rony , Tohme Cyril , Noun Roger , Sarkis Riad 
Published: April 2008

AbstractBackgroundRoutine calcium and vitamin D administration and routine autotransplantation of parathyroid glands can prevent hypocalcemia after total thyroidectomy.MethodsRoutine autotransplantation of 1 or more parathyroid glands and oral calcium and vitamin D supplementation was used in 252 patients.ResultsOne, 2, or 3 parathyroid glands were autotransplanted in 223, 27, and 2 patients, respectively. Routine oral calcium and vitamin D was administered in postoperative period in all patients. Postoperative hypocalcemia occurred in 17%, of whom 1.6% had minor symptoms related to hypocalcemia. No patient developed permanent hypocalcemia during the follow‐up period. The postoperative stay was 1 day in 93.6% of the cases. The incidence of postoperative hypocalcemia and hospital stay was higher in patients who underwent autotransplantation of more than 1 parathyroid gland.ConclusionsRoutine oral calcium and vitamin D supplementation and autotransplantation of at least 1 parathyroid gland effectively reduced symptomatic hypocalcemia and permanent hypoparathyroidism in total thyroidectomy. © 2008 Wiley Periodicals, Inc. Head Neck, 2008
Nicotinic acetylcholine receptor expression in the hippocampus of 27 mouse strains reveals novel inhibitory circuitry
Authors: Gahring Lorise C. , Rogers Scott W. 
Published: April 2008

AbstractMouse strains are well‐characterized to exhibit differences in their physiological and behavioral responses to nicotine. This report examines the expression of the high‐affinity nicotine binding receptor subunit, neuronal nicotinic receptor subunit alpha4 (nAChRα4), in the dorsal hippocampus of 27 inbred mouse strains. Multiple differences among mouse strains in the cellular expression of nAChRα4 between subregions of the hippocampal field are evident. Differences that we describe in the expression of nAChRα4 suggest mouse strains of diverse genetic origin could exhibit significant variation in how this receptor contributes to modulating intrahippocampal circuitry. These findings define a genetic frame‐work in which the strain‐specific responses to nicotine include underlying contributions by the varied anatomical context in which nAChRs are expressed. © 2008 Wiley‐Liss, Inc.
Hippocampal and amygdala volumes in children and adults with childhood maltreatment‐related posttraumatic stress disorder: A meta‐analysis
Authors: Woon Fu L. , Hedges Dawson W. 
Published: April 2008

AbstractLittle work has directly examined the course of hippocampal volume in children and adults with childhood maltreatment‐related posttraumatic stress disorder (PTSD). Data from adults suggest that hippocampal volume deficits are associated with PTSD, whereas findings from children with PTSD generally show no hippocampal volume deficits in PTSD. Additionally, the role of the amygdala in emotional response makes it a possible region for investigation in children and adults with childhood maltreatment‐related PTSD. The objectives of this study were 2‐fold: (1) to meta‐analytically determine whether hippocampal and amygdala volumes in children and adults with PTSD from childhood maltreatment differ from those in healthy controls, and (2) to use cross‐sectional findings performed with meta‐analyses as a proxy for longitudinal studies to estimate the course of hippocampal and amygdala volumes in child and adult subjects with PTSD from childhood maltreatment. Using electronic databases, we identified articles containing hippocampal and amygdala data for children with PTSD and adults with PTSD from childhood maltreatment. Data were extracted and effect sizes were calculated using Comprehensive Meta‐Analysis Version 2.0. Reduced bilateral hippocampal volume was found in adults with childhood maltreatment‐related PTSD compared with healthy controls, but this deficit was not seen in children with maltreatment‐related PTSD, suggesting hippocampal volume deficits from childhood maltreatment may not be apparent until adulthood. Greater left than right hippocampal volume was found in the adult healthy control group but not in the PTSD group. Amygdala volume in children with maltreatment‐related PTSD did not differ from that in healthy controls. Hippocampal volume is normal in children with maltreatment‐related PTSD but not in adults with PTSD from childhood maltreatment, suggesting an initially volumetrically normal hippocampus with subsequent abnormal volumetric development occurring after trauma exposure. However, longitudinal studies are needed to support these preliminary findings. © 2008 Wiley‐Liss, Inc.
Postnephrectomy fistula between the renal artery stump and inferior vena cava treated with Amplatzer vascular plug: Gray‐scale and Doppler sonographic findings
Authors: Taneja Manish , Metupalle Vasanthan , Hiong Tay Kiang , Soo Tan Bien , Htoo Austin 
Published: April 2008

AbstractFistulous communication between the renal artery stump and the inferior vena cava is a rare complication of nephrectomy. We report a case of an adult male in whom a fistula was detected on investigation for persistent postoperative anemia. The fistula was initially identified with Doppler sonography and subsequently confirmed on a catheter angiogram. It was successfully occluded percutaneously with an Amplatzer vascular plug. The plug had a distinctive appearance on subsequent sonographic studies that was useful for follow‐up evaluation. © 2008 Wiley Periodicals, Inc. J Clin Ultrasound, 2008
Sonographic findings of healthy volunteers infected with dengue virus
Authors: Statler John , Mammen Mammen , Lyons Arthur , Sun Wellington 
Published: April 2008

AbstractPurpose.Sonography has historically been used in developing countries to help diagnose dengue infection during epidemics of dengue hemorrhagic fever in endemic areas and to predict the clinical course. In this article, we describe the sonographic findings in subjects infected with attenuated, monovalent strains of dengue virus.Methods.As part of a major research protocol to validate challenge strains of dengue virus for use in vaccines, 12 subjects were infected with 1 of 4 strains of dengue virus, and 3 subjects received placebo. The challenge was followed by an observation period. During this time, they were imaged regardless of the development of symptoms.Results.Seven of 12 subjects infected with dengue virus showed sonographic evidence of subclinical plasma leakage, including perihepatic and perisplenic ascites, pericardial effusion, and gallbladder wall thickening. None of the 3 placebo recipients developed effusions.Conclusion.Sonographic evidence of fluid collection was seen in over half of subjects infected with dengue virus who did not show any evidence of dengue hemorrhagic fever. These findings shed light on possible mechanisms of plasma leakage and its role in the pathogenesis of dengue fever and dengue hemorrhagic fever. © 2008 Wiley Periodicals, Inc. J Clin Ultrasound, 2008