bluuebunny/crossref_metadata_2025_split huggingface dataset:
Social Discipline and the Refusal of Poor Relief under the English Old Poor Law, c. 1650–1730
Authors: Healey Jonathan 
Published: April 2024

AbstractThere has been debate about the extent to which the English old poor law could operate as a system of social discipline. This article looks closely at an almost completely neglected set of sources, petitions by local communities asking to stop (or cut) a pauper’s relief, to assess how far poor relief was used as a disciplinary tool. Taking 182 appeals by Lancashire townships from the Civil War to the appearance of workhouses in the county, it suggests that poor relief operated robustly as a system of labour discipline, but only weakly as a wider tool of behavioural control. There is some evidence that townships wanted to end doles to those engaged in ‘bad’ behaviour, such as excessive drinking, gambling, or insubordination, but such cases were infrequent. Far more important were attempts to stop relief where paupers could work or could support themselves through their own productive assets. In turn, townships’ focus on the ability to work suggests that ‘deserving’ poverty was understood in terms of bodily impotence, whilst the need to restrict poor relief to those who were ‘necessitous’ required officers to engage in close surveillance of the poor and their bodies.
Non-aureus staphylococci and mammaliicocci (NASM): their role in bovine mastitis and One Health
Authors: Crippa Bruna Lourenço , de Matos Luiz Gustavo , Souza Fernando Nogueira , Silva Nathália Cristina Cirone 
Published: April 2024

AbstractNon-aureus staphylococci (NAS) are gaining importance in mastitis and public health, and some NAS have been reclassified as mammaliicocci (NASM). Bovine milk production has a major influence on the world economy, being an essential source of income for small, medium and large producers, and bovine mastitis caused by NASM can cause an economic impact. Mastitis generates financial losses due to reduced revenue, increased veterinary costs and expenses associated with animal slaughter. However, it is also a public health issue involving animal health and welfare, human health and the ecosystem. Furthermore, it is an increasingly common infection caused by NASM, including antimicrobial-resistant strains. Despite all these adverse effects that NASM can cause, some studies also point to its protective role against mastitis. Therefore, this review article addresses the negative and positive aspects that NASM can cause in bovine mastitis, the virulence of the disease and resistance factors that make it difficult to treat and, through the One Health approach, presents a holistic view of how mastitis caused by NASM can affect both animal and human health at one and the same time.
Cortical volume alterations in the limbic network in adolescents with high reactive aggression
Authors: Bashford-Largo Johannah , Blair R. James R. , Blair Karina S. , Dobbertin Matthew , Elowsky Jaimie , Dominguez Ahria , Hatch Melissa , Bajaj Sahil 
Published: April 2024

Abstract
Previous studies show aggression-related structural alterations in frontal and limbic brain regions. Most studies have focused on overall aggression, instead of its subtypes, and on specific regions instead of networks. This study aims to identify both brain networks and regions that are associated with reactive and proactive subtypes of aggression. Structural MRI data were collected from 340 adolescents (125 F/215 M) with a mean age of 16.29 (SD = 1.20). Aggression symptomology was indexed via the Reactive Proactive Aggression Questionnaire (RPQ). Freesurfer was used to estimate Cortical Volume (CV) from seven networks and regions within specific networks associated with aggression. Two multivariate analyses of covariance (MANCOVAs) were conducted on groups for low versus higher reactive and proactive RPQ scores. Our reactive aggression MANCOVA showed a main effect in CV [F(14,321) = 1.935, p = 0.022,ηp2 = 0.078] across all the 7-Networks. Unpacking this main effect revealed significant volumetric differences in the right Limbic Network (LN) (p = 0.029) and the Temporal Pole (p = 0.011), where adolescents in the higher reactive aggression group showed higher cortical volumes. Such findings are consistent with region/voxel-specific analyses that have associated atypical structure within the LN and reactive aggression. Moreover, the temporal pole is highly interconnected with regions important in the regulation and initiation of reactive aggression.
Chronic pain–mental health comorbidity and excess prevalence of health risk behaviours: a cross-sectional study
Authors: Lumley Sophie , Yu Dahai , Wilkie Ross , Jordan Kelvin P. , Peat George 
Published: April 2024

Abstract

Background:
Chronic musculoskeletal pain and anxiety/depression are significant public health problems. We hypothesised that adults with both conditions constitute a group at especially high risk of future cardiovascular health outcomes.

Aim:
To determine whether having comorbid chronic musculoskeletal pain and anxiety/depression is associated with the excess prevalence of selected known cardiovascular health risk behaviours.

Method:
A cross-sectional survey of adults aged 35+ years randomly sampled from 26 GP practice registers in West Midlands, England. Respondents were classified into four groups based on self-reported presence/absence of chronic musculoskeletal pain (pain present on most days for six months) and anxiety or depression (Hospital Anxiety and Depression Score 11+). Standardised binomial models were used to estimate standardised prevalence ratios and prevalence differences between the four groups in self-reported obesity, tobacco smoking, physical inactivity, and unhealthy alcohol consumption after controlling for age, sex, ethnicity, deprivation, employment status and educational attainment. The excess prevalence of each risk factor in the group with chronic musculoskeletal pain–anxiety/depression comorbidity was estimated.

Findings:
Totally, 14 519 respondents were included, of whom 1329 (9%) reported comorbid chronic musculoskeletal pain–anxiety/depression, 3612 (25%) chronic musculoskeletal pain only, 964 (7%) anxiety or depression only, and 8614 (59%) neither. Those with comorbid chronic musculoskeletal pain–anxiety/depression had the highest crude prevalence of obesity (41%), smoking (16%) and physical inactivity (83%) but the lowest for unhealthy alcohol consumption (18%). After controlling for covariates, the standardised prevalence ratios and differences for the comorbid group compared with those with neither chronic musculoskeletal pain nor anxiety/depression were as follows: current smoking [1.86 (95% CI 1.58, 2.18); 6.8%], obesity [1.93 (1.76, 2.10); 18.9%], physical inactivity [1.21 (1.17, 1.24); 14.3%] and unhealthy alcohol consumption [0.81 (0.71, 0.92); –5.0%]. The standardised prevalences of smoking and obesity in the comorbid group exceeded those expected from simple additive interaction.
Some head starts are bigger than others: dynastic legacies and variation in candidate quality in Taiwan's local elections
Authors: Batto Nathan F. , Read Benjamin L. 
Published: April 2024

AbstractCandidates from established political families are more likely to win than their non-dynastic counterparts because their political inheritance often includes significant advantages in resources and reputation. Yet dynastic candidates also bring their own set of experiences and qualities to the game. Is it the case that their individual characteristics can explain their electoral success, or is their success due to their family legacy? Theoretically, how and when are political resources transferred to the new generation? We examine these questions by looking at non-incumbent candidates in city and county council elections in Taiwan from 2009 to 2014, drawing on unique data on politicians' backgrounds. The profile of dynastic candidates differs from that of non-dynastic candidates: they are younger, have less electoral experience and list experience in different sorts of organizations and jobs. However, these differences are not what drives their electoral success; indeed, they tend to win despite these qualities rather than because of them. Even after controlling for candidate quality, dynastic status remains a powerful predictor, conveying roughly a 20 percentage point increase in the probability of winning. This suggests that while dynastic candidates accrue some of their advantage long before they run for office, a large part of the inheritance is transferred during the campaign.
The Future of Developed Barrier Systems: 1. Pathways Toward Uninhabitability, Drowning, and Rebound
Authors: Anarde K. A. , Moore L. J. , Murray A. B. , Reeves I. R. B. 
Published: April 2024

AbstractMany barrier islands and spits (collectively, “barriers”) throughout the world are highly developed. As low‐lying, sandy coastal landforms, barrier systems are naturally reshaped by processes associated with storms and sea‐level rise (SLR). The resulting landscape changes threaten development, and in response, humans employ defensive measures that physically modify barrier geometry to reduce relatively short‐term risk. These measures include the construction of large dunes, emplacement of beach nourishment, and removal of washover. Simulations conducted using a new coupled modeling framework show that, over decades to centuries, measures to protect roadways and communities alter the physical characteristics of barrier systems in ways that ultimately limit their habitability. We find that the pathway toward uninhabitability (via roadway drowning or community narrowing) and future system states (drowning or rebound) depends largely on dune management—because building dunes blocks overwash delivery to the barrier interior—and on initial conditions (barrier elevation and width). In the model, barriers can become lower and narrower with SLR to the point of drowning. The timing and occurrence of barrier drowning depends on randomness in the timing and intensity of storms and dune recovery processes. We find that under a constant rate of SLR, negative feedbacks involving storms can allow barriers that do not drown to rebound toward steady‐state geometries within decades after management practices cease.
Channel Development and Electric Parameter Characteristics of Regular Pulse Bursts in Lightning
Authors: Fan X. , Zhang Y. , Krehbiel P. , Zheng D. , Yao W. , Zhang Y. , Xu L. , Liu H. , Lyu W. 
Published: April 2024

AbstractObservations of a regular pulse burst (RPB) at the end of a K‐event are analyzed utilizing a simple geometric model and particle swarm optimization (PSO) to estimate the currents and propagation speeds of successive pulses of the RPB. The results show that the current of successive pulses is strongly overlapped and, for typical speeds of continuously propagating K‐events, are unphysically large (88 kA), exceeding the currents of most strokes to ground. By default, the unphysical nature of the result, coupled with very high frequency interferometer observations of an RPB in Florida, shows that the propagation speed of the pulses is significantly faster than expected, namely ∼0.6–1.8 × 108 m/s. This reduces the inferred current from 88 kA down to 6–18 kA, typical of intracloud events. The fast propagation speed of the stepping is explained by successive pulses retracing much of the path of the preceding pulses due to the successive pulses being strongly overlapped.
Statistical Analysis of Off‐Great Circle Radio Wave Propagation in the Polar Cap
Authors: Cameron T. G. , Fiori R. A. D. , Perry G. W. , Spicher A. , Thayaparan T. 
Published: April 2024

AbstractHigh latitude ionospheric density structures such as polar cap patches and arcs are capable of deflecting high frequency (HF) radio waves to off‐great circle paths, and are likely detrimental to technologies dependent on HF radio propagation. In this study, nearly 2.5 years of 4.6–14.4 MHz data from a multi‐frequency HF radio link between Qaanaaq, Greenland and Alert, Canada are used to investigate high‐latitude off‐great circle propagation in the polar cap. After an example of HF radio propagation affected by polar cap patches is shown in detail, a statistical analysis of the occurrence and impacts of off‐great circle deflections in the polar cap is presented. Off‐great circle propagation is shown to be increasingly common with increasing frequency up to 11.1 MHz, such that averaged over 1 year, received 11.1 MHz signals experienced deflections >30° from the great circle direction 65.6% of the time. The occurrence of these deflections across the year is shown to be at a maximum in the winter, while occurrence across the day varies with season. Trends across both time of day and time of year for 11.1 and 14.4 MHz deflections are consistent with polar cap patch occurrence trends. Off‐great circle deflections are shown to be associated with increased time‐of‐flights, a larger range of positive and negative Doppler shifts, increased Doppler spreads, and lower signal‐to‐noise ratios. These results are discussed in the context of ionospheric phenomena in the polar cap, and implications for over‐the‐horizon radars operating at high latitudes.
Effect of Seismicity and Tectonic‐Glacial Interactions on Submarine Megaslides
Authors: Gulick Sean P. S. , Reece Robert S. , Sawyer Derek E. , Christeson Gail L. , Horton Brian K. 
Published: April 2024

AbstractEnhanced sedimentation at glacial margins can produce submarine megaslides (>10,000 km3). We report a single megaslide in the Surveyor Fan, Gulf of Alaska. Minimum extant size is ∼16,124 km2 in area and ∼9,080 km3 in volume. Slope failure occurred ∼1.2 Ma at the onset of the mid‐Pleistocene transition (MPT). With accretion along the Aleutian‐Alaska Trench, the original volume is conservatively ∼16,280 km3, with only a 140 km run‐out due to its blocky, high shear strength nature. We suggest the megaslide was triggered by a major sediment influx at the onset of the MPT, when glacial‐interglacial cycles shifted from 41 to 100 Kyr. The absence of repeat megaslides may reflect a changing balance between seismic strengthening and sediment flux, where later sedimentation driven by cross‐shelf ice streams results in thin, fluidized, non‐cohesive slides. Continued accretion of the Surveyor Fan and megaslide also reduces critical wedge taper, further inhibiting major failure.
Usual intake of dairy products and the chance of pre-diabetes regression to normal glycemia or progression to type 2 diabetes: a 9-year follow-up
Authors: Bahadoran Zahra , Mirmiran Parvin , Azizi Fereidoun 
Published: April 2024

Abstract
Background
We assessed the possible effect of usual dairy consumption on pre-diabetes (Pre-DM) remission or progression to type 2 diabetes (T2D).

Methods
Pre-DM adults (n = 334, mean age of 49.4 years, and 51.5% men) were assessed for dairy intakes (2006–2008) and followed up to 9 years for incidence of T2D or normal glycemia (NG). All biochemical measurements were done at baseline and all subsequent examinations with 3-y follow-up intervals. Multinomial regression models with adjustment of confounding variables were used to estimate odds ratios (OR) and 95% confidence intervals (CIs) of incident T2D and NG for each serving/d dairy consumption.

Results
The odds of NG was significantly elevated by 69% (OR = 1.69, 95% CI = 1.00–2.86, P = 0.05) per 200 g/d increased high-fat dairy intake, while the amount of total dairy or low-fat dairy was not related to the outcomes. Higher intakes of yogurt were more likely to be associated with an increased odds of NG (OR = 1.82, 95% CI = 1.20–2.74, P = 0.01). Usual intakes of milk, cheese, or cream-butter were not associated to Pre-DM remission or progression to T2D.

Conclusion
Regular dairy consumption may increase the chance of Pre-DM regression to NG.
Association of food insecurity with changes in diet quality, weight, and glycemia over two years in adults with prediabetes and type 2 diabetes on medicaid
Authors: Gu Kristine D. , Cheng Jessica , Fung Vicki , Levy Douglas E. , McGovern Sydney , McCurley Jessica L. , Clark Cheryl R. , Thorndike Anne N. 
Published: April 2024

AbstractLittle is known about longitudinal associations between food insecurity (FI) and diet, weight, and glycemia in people with prediabetes and type 2 diabetes (T2D). In a secondary analysis of Medicaid-enrolled health center patients with prediabetes or T2D in Boston, Massachusetts (N = 188), we examined associations between food security (FS) and measures of diet quality, weight, and hyperglycemia. FS (10-item USDA FS module) was ascertained at baseline, 1-year, and 2-year follow-up and categorized as persistently secure, intermittently insecure, or persistently insecure. Associations between FS category and changes in Healthy Eating Index-2020 (HEI-20), body mass index (BMI), and hemoglobin A1c (A1c) from baseline to year 2 were assessed using multivariate generalized linear models. Participants had median (p25, p75) age of 52 (42, 57); 71.8% were female and 62.8% Hispanic. Over follow-up, 32.4% were persistently food secure, 33.0% intermittently insecure, and 34.5% persistently insecure. Baseline mean (SD) HEI-20, BMI, and A1c were 55.8 (14.5), 35.9 (8.7) kg/m2, 7.1% (1.6) and did not differ by FS category. FS category was not associated with changes in HEI-20, BMI, and A1c at 2 years (all p > 0.05). Results suggest that Medicaid-enrolled adults with prediabetes or T2D, regardless of FS status, would benefit from dietary and weight management interventions.
Dynamic genomic changes in methotrexate-resistant human cancer cell lines beyond DHFR amplification suggest potential new targets for preventing drug resistance
Authors: Meng Xiang-Ning , Ma Jin-Fa , Liu Yang-He , Li Si-Qing , Wang Xu , Zhu Jing , Cai Meng-Di , Zhang Hui-Shu , Song Tiantian , Xing Shukai , Hou Li-Qing , Guo Huan , Cui Xiao-Bo , Han Jiang , Liu Peng , Ji Guo-Hua , Sun Wen-Jing , Yu Jing-Cui , Fu Song-Bin 
Published: April 2024

Abstract
Background
Although DHFR gene amplification has long been known as a major mechanism for methotrexate (MTX) resistance in cancer, the early changes and detailed development of the resistance are not yet fully understood.

Methods
We performed genomic, transcriptional and proteomic analyses of human colon cancer cells with sequentially increasing levels of MTX-resistance.

Results
The genomic amplification evolved in three phases (pre-amplification, homogenously staining region (HSR) and extrachromosomal DNA (ecDNA)). We confirm that genomic amplification and increased expression of DHFR, with formation of HSRs and especially ecDNAs, is the major driver of resistance. However, DHFR did not play a detectable role in the early phase. In the late phase (ecDNA), increase in FAM151B protein level may also have an important role by decreasing sensitivity to MTX. In addition, although MSH3 and ZFYVE16 may be subject to different posttranscriptional regulations and therefore protein expressions are decreased in ecDNA stages compared to HSR stages, they still play important roles in MTX resistance.

Conclusion
The study provides a detailed evolutionary trajectory of MTX-resistance and identifies new targets, especially ecDNAs, which could help to prevent drug resistance. It also presents a proof-of-principal approach which could be applied to other cancer drug resistance studies.
Dietary factors and their influence on immunotherapy strategies in oncology: a comprehensive review
Authors: Golonko Aleksandra , Pienkowski Tomasz , Swislocka Renata , Orzechowska Sylwia , Marszalek Krystian , Szczerbinski Lukasz , Swiergiel Artur Hugo , Lewandowski Wlodzimierz 
Published: April 2024

AbstractImmunotherapy is emerging as a promising avenue in oncology, gaining increasing importance and offering substantial advantages when compared to chemotherapy or radiotherapy. However, in the context of immunotherapy, there is the potential for the immune system to either support or hinder the administered treatment. This review encompasses recent and pivotal studies that assess the influence of dietary elements, including vitamins, fatty acids, nutrients, small dietary molecules, dietary patterns, and caloric restriction, on the ability to modulate immune responses. Furthermore, the article underscores how these dietary factors have the potential to modify and enhance the effectiveness of anticancer immunotherapy. It emphasizes the necessity for additional research to comprehend the underlying mechanisms for optimizing the efficacy of anticancer therapy and defining dietary strategies that may reduce cancer-related morbidity and mortality. Persistent investigation in this field holds significant promise for improving cancer treatment outcomes and maximizing the benefits of immunotherapy.
Decoding spatiotemporal transcriptional dynamics and epithelial fibroblast crosstalk during gastroesophageal junction development through single cell analysis
Authors: Kumar Naveen , Prakash Pon Ganish , Wentland Christian , Kurian Shilpa Mary , Jethva Gaurav , Brinkmann Volker , Mollenkopf Hans-Joachim , Krammer Tobias , Toussaint Christophe , Saliba Antoine-Emmanuel , Biebl Matthias , Jürgensen Christian , Wiedenmann Bertram , Meyer Thomas F. , Gurumurthy Rajendra Kumar , Chumduri Cindrilla 
Published: April 2024

AbstractThe gastroesophageal squamocolumnar junction (GE-SCJ) is a critical tissue interface between the esophagus and stomach, with significant relevance in the pathophysiology of gastrointestinal diseases. Despite this, the molecular mechanisms underlying GE-SCJ development remain unclear. Using single-cell transcriptomics, organoids, and spatial analysis, we examine the cellular heterogeneity and spatiotemporal dynamics of GE-SCJ development from embryonic to adult mice. We identify distinct transcriptional states and signaling pathways in the epithelial and mesenchymal compartments of the esophagus and stomach during development. Fibroblast-epithelial interactions are mediated by various signaling pathways, including WNT, BMP, TGF-β, FGF, EGF, and PDGF. Our results suggest that fibroblasts predominantly send FGF and TGF-β signals to the epithelia, while epithelial cells mainly send PDGF and EGF signals to fibroblasts. We observe differences in the ligands and receptors involved in cell-cell communication between the esophagus and stomach. Our findings provide insights into the molecular mechanisms underlying GE-SCJ development and fibroblast-epithelial crosstalk involved, paving the way to elucidate mechanisms during adaptive metaplasia development and carcinogenesis.
LDL receptor-related protein 5 selectively transports unesterified polyunsaturated fatty acids to intracellular compartments
Authors: Tang Wenwen , Luan Yi , Yuan Qianying , Li Ao , Chen Song , Menacherry Stanley , Young Lawrence , Wu Dianqing 
Published: April 2024

AbstractPolyunsaturated fatty acids (PUFAs), which cannot be synthesized by animals and must be supplied from the diet, have been strongly associated with human health. However, the mechanisms for their accretion remain poorly understood. Here, we show that LDL receptor-related protein 5 (LRP5), but not its homolog LRP6, selectively transports unesterified PUFAs into a number of cell types. The LDLa ligand-binding repeats of LRP5 directly bind to PUFAs and are required and sufficient for PUFA transport. In contrast to the known PUFA transporters Mfsd2a, CD36 and FATP2, LRP5 transports unesterified PUFAs via internalization to intracellular compartments including lysosomes, and n-3 PUFAs depend on this transport mechanism to inhibit mTORC1. This LRP5-mediated PUFA transport mechanism suppresses extracellular trap formation in neutrophils and protects mice from myocardial injury during ischemia-reperfusion. Thus, this study reveals a biologically important mechanism for unesterified PUFA transport to intracellular compartments.