bluuebunny/crossref_metadata_2025_split huggingface dataset:
When Trust in AI Mediates: AI News Use, Public Discussion, and Civic Participation
Authors: Nah Seungahn , Liu Fanjue , Shao Chun , Romanova Ekaterina , Nam Gwiwon 
Published: April 2024

AbstractArtificial intelligence (AI), since its marked proliferation in the mid-2010s, has significantly penetrated various sectors, becoming a transformative force that necessitates ongoing refinement of communication strategies and political dynamics by stakeholders. Drawing on the Orientation-Stimulus-Reasoning-Orientation-Response (O-S-R-O-R) model, this study delves into the role of AI news consumption in participatory democracy. Using data from a nationwide survey (N = 1,252), the study assesses a mediation model that proposes a multilayered process through which AI news consumption facilitates civic participation. The findings reveal that AI news consumption across different media platforms is positively linked with civic participation, facilitated by both online and offline AI discussions. This relationship is further mediated by trust in AI news and trust in AI actors. Further theoretical and practical implications are also discussed.
Symplectic Fourier–Deligne Transforms on G/U and the Algebra of Braids and Ties
Authors: Morton-Ferguson Calder 
Published: April 2024

Abstract
We explicitly identify the algebra generated by symplectic Fourier–Deligne transforms (i.e., convolution with Kazhdan–Laumon sheaves) acting on the Grothendieck group of perverse sheaves on the basic affine space $G/U$, answering a question originally raised by A. Polishchuk. We show it is isomorphic to a distinguished subalgebra, studied by I. Marin, of the generalized algebra of braids and ties (defined in Type $A$ by F. Aicardi and J. Juyumaya and generalized to all types by Marin), providing a connection between geometric representation theory and an algebra defined in the context of knot theory. Our geometric interpretation of this algebra entails some algebraic consequences: we obtain a short and type-independent geometric proof of the braid relations for Juyumaya’s generators of the Yokonuma–Hecke algebra (previously proved case-by-case in types $A, D, E$ by Juyumaya and separately for types $B, C, F_{4}, G_{2}$ by Juyumaya and S. S. Kannan), a natural candidate for an analogue of a Kazhdan–Lusztig basis, and finally an explicit formula for the dimension of Marin’s algebra in Type $A_{n}$ (previously only known for $n \leq 4$).
When simplicity triumphs: niche specialization of gut bacteria exists even for simple fiber structures
Authors: Xu Haidi , Pudlo Nicholas A , Cantu-Jungles Thaisa M , Tuncil Yunus E , Nie Xin , Kaur Amandeep , Reuhs Bradley L , Martens Eric C , Hamaker Bruce R 
Published: April 2024

Abstract
Structurally complex corn bran arabinoxylan (CAX) was used as a model glycan to investigate gut bacteria growth and competition on different AX-based fine structures. Nine hydrolyzate segments of the CAX polymer varying in chemical structure (sugars and linkages), CAX, five less complex non-corn arabinoxylans, and xylose and glucose were ranked from structurally complex to simple. The substrate panel promoted different overall growth and rates of growth of eight Bacteroides xylan-degrading strains. For example, Bacteroides cellulosilyticus DSM 14838 (Bacteroides cellulosilyticus) grew well on an array of complex and simple structures, while Bacteroides ovatus 3-1-23 grew well only on the simple structures. In a competition experiment, B. cellulosilyticus growth was favored over B. ovatus on the complex AX-based structure. On the other hand, on the simple structure, B. ovatus strongly outcompeted B. cellulosilyticus, which was eliminated from the competitive environment by Day 11. This adaptation to fine structure and resulting competition dynamics indicate that dietary fiber chemical structures, whether complex or simple, favor certain gut bacteria. Overall, this work supports a concept that fiber degraders diversify their competitive abilities to access substrates across the spectrum of heterogeneity of fine structural features of dietary fibers.
A blockchain-based healthcare data marketplace: prototype and demonstration
Authors: Kim KangHyun , Kim Sung-Min , Park YoungMin , Lee EunSol , Jung SungJae , Kang Jeongyong , An DongUk , Min Kyungil , Shim Sung Ryul , Yu Hyeong Won , Han Hyun Wook 
Published: April 2024

Abstract

Objectives
This study aimed to develop healthcare data marketplace using blockchain-based B2C model that ensures the transaction of healthcare data among individuals, companies, and marketplaces.

Materials and methods
We designed an architecture for the healthcare data marketplace using blockchain. A healthcare data marketplace was developed using Panacea, MySQL 8.0, JavaScript library, and Node.js. We evaluated the performance of the data marketplace system in 3 scenarios.

Results
We developed mobile and web applications for healthcare data marketplace. The transaction data queries were executed fully within about 1-2 s, and approximately 9.5 healthcare data queries were processed per minute in each demonstration scenario.

Discussion
Blockchain-based healthcare data marketplaces have shown compliance performance in the process of data collection and will provide a meaningful role in analyzing healthcare data.

Conclusion
The healthcare data marketplace developed in this project can iron out time and place limitations and create a framework for gathering and analyzing fragmented healthcare data.
Green’s matching: an efficient approach to parameter estimation in complex dynamic systems
Authors: Tan Jianbin , Zhang Guoyu , Wang Xueqin , Huang Hui , Yao Fang 
Published: April 2024

Abstract
Parameters of differential equations are essential to characterize intrinsic behaviours of dynamic systems. Numerous methods for estimating parameters in dynamic systems are computationally and/or statistically inadequate, especially for complex systems with general-order differential operators, such as motion dynamics. This article presents Green’s matching, a computationally tractable and statistically efficient two-step method, which only needs to approximate trajectories in dynamic systems but not their derivatives due to the inverse of differential operators by Green’s function. This yields a statistically optimal guarantee for parameter estimation in general-order equations, a feature not shared by existing methods, and provides an efficient framework for broad statistical inferences in complex dynamic systems.
Polluting white dwarfs with Oort cloud comets
Authors: Pham Dang , Rein Hanno 
Published: April 2024

ABSTRACT
Observations point to old white dwarfs (WDs) accreting metals at a relatively constant rate over 8 Gyr. Exo-Oort clouds around WDs have been proposed as potential reservoirs of materials, with galactic tide as a mechanism to deliver distant comets to the WD’s Roche limit. In this work, we characterize the dynamics of comets around a WD with a companion having semimajor axes on the orders of 10–100 au. We develop simulation techniques capable of integrating a large number (108) of objects over a 1 Gyr time-scale. Our simulations include galactic tide and are capable of resolving close interactions with a massive companion. Through simulations, we study the accretion rate of exo-Oort cloud comets into a WD’s Roche limit. We also characterize the dynamics of precession and scattering induced on a comet by a massive companion. We find that (i) WD pollution by an exo-Oort cloud can be sustained over a Gyr time-scale, (ii) an exo-Oort cloud with structure like our own Solar system’s is capable of delivering materials into an isolated WD with pollution rate ∼108 g s−1, (iii) adding a planetary-mass companion reduces the pollution rate to ∼107 g s−1, and (iv) if the companion is stellar mass, with Mp ≳ 0.1 M⊙, the pollution rate reduces to ∼3 × 105 g s−1 due to a combination of precession induced on a comet by the companion, a strong scattering barrier, and low likelihood of direct collisions of comets with the companion.
Evidence of the γ-ray counterpart of nova FM Cir from Fermi–LAT
Authors: Wang H H , Yan H D , Lin L C -C , Takata J , Tam P-H T 
Published: April 2024

ABSTRACT
We report the results of an analysis of X-ray and γ-ray data from the nova FM Cir taken by Swift and Fermi–LAT. The γ-ray emission from FM Cir can be identified with a significance level of ∼3σ within ∼40 d after the nova eruption (2018 January 19) when we bin the light curve per day. The significance can exceed the 4σ confidence level if we accumulate a longer time (i.e. 20 d) to bin the light curve. The γ-ray counterpart could be identified with a Test Statistic (TS) above 4 until ∼180 d after the eruption. The duration of the γ-ray detection is longer than those reported in previous studies of other novae detected in the GeV range. Significant X-ray emission was observed after the γ-ray flux level fell below the sensitivity limit of Fermi–LAT. The hardness ratio of the X-ray emission decreased rapidly with time, and the spectra were dominated by blackbody radiation from the hot white dwarf. Except for the longer duration of the γ-ray emission, the multiwavelength properties of FM Cir closely resemble those of other novae detected in the GeV range.
Quantum-inspired analysis of neural network vulnerabilities: the role of conjugate variables in system attacks
Authors: Zhang Jun-Jie , Meng Deyu 
Published: April 2024

ABSTRACT
Neural networks demonstrate vulnerability to small, non-random perturbations, emerging as adversarial attacks. Such attacks, born from the gradient of the loss function relative to the input, are discerned as input conjugates, revealing a systemic fragility within the network structure. Intriguingly, a mathematical congruence manifests between this mechanism and the quantum physics’ uncertainty principle, casting light on a hitherto unanticipated interdisciplinarity. This inherent susceptibility within neural network systems is generally intrinsic, highlighting not only the innate vulnerability of these networks, but also suggesting potential advancements in the interdisciplinary area for understanding these black-box networks.
Human CD56+CD39+ dNK cells support fetal survival through controlling trophoblastic cell fate: immune mechanisms of recurrent early pregnancy loss
Authors: Jia Wentong , Ma Liyang , Yu Xin , Wang Feiyang , Yang Qian , Wang Xiaoye , Fan Mengjie , Gu Yan , Meng Ran , Wang Jian , Li Yuxia , Li Rong , Shao Xuan , Wang Yan-Ling 
Published: April 2024

ABSTRACT
Decidual natural killer (dNK) cells are the most abundant immune cells at the maternal-fetal interface during early pregnancy in both mice and humans, and emerging single-cell transcriptomic studies have uncovered various human dNK subsets that are disrupted in patients experiencing recurrent early pregnancy loss (RPL) at early gestational stage, suggesting a connection between abnormal proportions or characteristics of dNK subsets and RPL pathogenesis. However, the functional mechanisms underlying this association remain unclear. Here, we established a mouse model by adoptively transferring human dNK cells into pregnant NOG (NOD/Shi-scid/IL-2Rγnull) mice, where human dNK cells predominantly homed into the uteri of recipients. Using this model, we observed a strong correlation between the properties of human dNK cells and pregnancy outcome. The transfer of dNK cells from RPL patients (dNK-RPL) remarkably worsened early pregnancy loss and impaired placental trophoblast cell differentiation in the recipients. These adverse effects were effectively reversed by transferring CD56+CD39+ dNK cells. Mechanistic studies revealed that CD56+CD39+ dNK subset facilitates early differentiation of mouse trophoblast stem cells (mTSCs) towards both invasive and syncytial pathways through secreting macrophage colony-stimulating factor (M-CSF). Administration of recombinant M-CSF to NOG mice transferred with dNK-RPL efficiently rescued the exacerbated pregnancy outcomes and fetal/placental development. Collectively, this study established a novel humanized mouse model featuring functional human dNK cells homing into the uteri of recipients and uncovered the pivotal role of M-CSF in fetal-supporting function of CD56+CD39+ dNK cells during early pregnancy, highlighting that M-CSF may be a previously unappreciated therapeutic target for intervening RPL.
Transcription factor PgNAC72 activates DAMMARENEDIOL SYNTHASE expression to promote ginseng saponin biosynthesis
Authors: Jiang Ting , Zhang Yue , Zuo Gege , Luo Tiao , Wang Hui , Zhang Ru , Luo Zhiyong 
Published: April 2024

Abstract
Ginsenosides, the primary bioactive constituents in ginseng (Panax ginseng), possess substantial pharmacological potential and are in high demand in the market. The plant hormone methyl jasmonate (MeJA) effectively elicits ginsenoside biosynthesis in P. ginseng, though the regulatory mechanism remains largely unexplored. NAC transcription factors are critical in intricate plant regulatory networks and participate in numerous plant physiological activities. In this study, we identified a MeJA-responsive NAC transcription factor gene, PgNAC72, from a transcriptome library produced from MeJA-treated P. ginseng callus. Predominantly expressed in P. ginseng flowers, PgNAC72 localizes to the nucleus. Overexpressing PgNAC72 (OE-PgNAC72) in P. ginseng callus notably elevated total saponin levels, particularly dammarane-type ginsenosides, by upregulating dammarenediol synthase (PgDDS), encoding a key enzyme in the ginsenoside biosynthesis pathway. Electrophoretic mobility shift assays and dual-luciferase assays confirmed that PgNAC72 binds to the NAC-binding elements in the PgDDS promoter, thereby activating its transcription. Further RNA-seq and terpenoid metabolomic data in the OE-PgNAC72 line confirmed that PgNAC72 enhances ginsenoside biosynthesis. These findings uncover a regulatory role of PgNAC72 in MeJA-mediated ginsenoside biosynthesis, providing insights into the ginsenoside regulatory network and presenting a valuable target gene for metabolic engineering.
Strategic borrowing from passive investors
Authors: Palia Darius , Sokolinski Stanislav 
Published: April 2024

Abstract
We find that short sellers manage risks by strategically borrowing shares in stocks with significant ownership by passive investors. This practice increases securities lending demand for stocks with substantial passive ownership, resulting in improved price efficiency, higher lending fees, and increased short interest in these stocks. Consistent with the risk mitigation motive, these stocks show reduced risks of unexpected fee hikes and loan recall, longer loan durations, and attract more informed short sellers. These effects are particularly pronounced in hard-to-borrow stocks where short-sale constraints are binding. Our study suggests that passive investing helps alleviate short-sale constraints by reducing the risks associated with stock borrowing.
EU resilience in investment protection: a case for revisiting and reinforcing the loyalty principle in EU external relations
Authors: Jaeger Thomas 
Published: April 2024

Abstract
This article explores the concept of European Union (EU) resilience in the area of investment protection and Investor–State dispute settlement. The article adopts a functional approach to investment protection and suggests that reforming dispute settlement procedures in line with current Commission initiatives is key to promoting open strategic autonomy for the EU. Support for those initiatives is however weak, also among EU Member States. It is argued that EU resilience requires new tools for more unity and coherence in external EU action, both generally and for the reform of Investor–State dispute settlement in particular. The tool devised here is an increased loyalty standard coupled with a justification test, based on both a modernized comprehensive reading of loyalty obligations in primary law and the effectiveness principle and rationale as applied in case law. The novel approach promises significantly better results in terms of commanding coherence in external action while fully respecting the principle of conferred powers. It challenges traditional power dynamics, but incorporates a bold vision for external EU action that is truly autonomous and assertive.
Reductions in World Health Organization Risk Drinking Level Are Associated With Reductions in Alcohol Use Disorder Diagnosis and Criteria: Evidence From an Alcohol Pharmacotherapy Trial
Authors: Richards Dylan K. , Tuchman Felicia R. , Hallgren Kevin A. , Kranzler Henry R. , Aubin Henri-Jean , O'Malley Stephanie S. , Mann Karl , Aldridge Arnie , Anton Raymond F. , Witkiewitz Katie 
Published: April 2024

Objectives
This study aimed to evaluate the validity of World Health Organization (WHO) risk drinking level reductions as meaningful endpoints for clinical practice and research. This study examined whether such reductions were associated with a lower likelihood of a current alcohol use disorder (AUD) diagnosis and fewer AUD criteria.

Methods
We conducted a secondary data analysis to address these objectives using data from a multisite randomized controlled trial of gabapentin enacarbil extended release in treating moderate to severe AUD among adults (N = 346). Participants received gabapentin enacarbil extended release or placebo for 6 months. The timeline follow-back was used to assess WHO risk drinking level reductions, and the Mini-International Neuropsychiatric Interview was used to assess Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition) AUD diagnosis and criteria at baseline (past year) and end of treatment (past month).

Results
Most participants (80.1%) achieved at least a 1-level reduction in the WHO risk drinking levels from baseline to end of treatment, and nearly half of participants (49.8%) achieved at least a 2-level reduction. At least a 1-level reduction or at least a 2-level reduction in WHO risk drinking level predicted lower odds of an active AUD diagnosis (1-level: odds ratio, 0.74 [95% confidence interval (CI), 0.66–0.84]; 2-level: odds ratio, 0.71 [95% CI, 0.64–0.79]) and fewer AUD criteria (1-level: B, −1.66 [95% CI, −2.35 to −0.98]; 2-level: B, −1.76 [95% CI, −2.31 to −1.21]) at end of treatment.

Conclusions
World Health Organization risk drinking level reductions correlate with Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition) AUD diagnosis and criteria, providing further evidence for their use as endpoints in alcohol intervention trials, which has potential implications for broadening the base of AUD treatment.
Association Between Severity of Cervical Central Spinal Stenosis and Paraspinal Muscle Parameters in Patients Undergoing Anterior Cervical Discectomy and Fusion
Authors: Caffard Thomas , Arzani Artine , Verna Bruno , Tripathi Vidushi , Chiapparelli Erika , Schönnagel Lukas , Zhu Jiaqi , Medina Samuel J. , Tani Soji , Camino-Willhuber Gaston , Guven Ali E. , Amoroso Krizia , Tan Ek Tsoon , Carrino John A. , Shue Jennifer , Kelly Michael J. , Burkhard Marco D. , Awan Malik Hassan , Zippelius Timo , Dalton David , Sama Andrew A. , Girardi Federico P. , Cammisa Frank P. , Hughes Alexander P. 
Published: April 2024

Study design:
Retrospective study.

Objective:
The aim of this study was to evaluate the association between severity and level of cervical central stenosis (CCS) and the fat infiltration (FI) of the cervical multifidus/rotatores (MR) at each subaxial levels.

Summary of Background Data:
The relationship between cervical musculature morphology and the severity of CCS is poorly understood.

Methods:
Patients with preoperative cervical magnetic resonance imaging (MRI) who underwent anterior cervical discectomy and fusion (ACDF) were reviewed. The cervical MR were segmented from C3 to C7 and the percent FI was measured using a custom-written Matlab software. The severity of the CCS at each subaxial level was assessed using a previously published classification. Grade 3, representing a loss of cerebrospinal fluid space and deformation of the spinal cord > 25%, was set as the reference and compared to the other gradings. Multivariable linear regression analyses were conducted and adjusted for age, sex, and body mass index.

Results:
156 consecutive patients were recruited. A spinal cord compression at a certain level was significantly associated with a greater FI of the MR below that level. After adjustment for the above-mentioned confounders, our results showed that spinal cord compression at C3/4 and C4/5 was significantly associated with greater FI of the MR from C3 to C6 and C5 to C7, respectively. A spinal cord compression at C5/6 or C6/7 was significantly associated with greater FI of the MR at C7.

Conclusion:
Our results demonstrated significant correlations between the severity of CCS and a greater FI of the MR. Moreover, significant level-specific correlations were found. A significant increase in FI of the MR at the levels below the stenosis was observed in patients presenting with spinal cord compression. Given the segmental innervation of the MR, the increased FI might be attributed to neurogenic atrophy.

Level of Evidence:
3
Inappropriate placement of urinary catheters into the ureter: A case report and literature review
Authors: Li Jiun-Jia , Au Chin-Fong 
Published: April 2024

Objective:
To emphasize preventive measures and outline management strategies for inadvertent ureteral cannulation.

Methods:
We present a case report and conduct a literature review of 39 case reports on ureteral cannulation, examining a total of 48 patients.

Results:
About 67% of the cases were female, and long-term catheterization was observed in 67% of the cases. Neurological conditions such as spinal cord injury (SCI), stroke, dementia, multiple sclerosis, and myasthenia gravis were the primary factors (48%) in ureteral cannulation. Symptoms included flank pain (46%), fever (31%), oliguria (27%), non-deflatable balloon issues (25%), hematuria (21%), abdominal pain (17%), urine leak (12.5%), and nausea/vomiting (8%). Complications varied, including acute pyelonephritis (35%), acute kidney injury (27%), urosepsis (21%), and ureter rupture (17%). Despite inadvertent catheter placement, 25% of patients had no complications. More than half of the patients (58%) were managed through catheter change, while 27% underwent cysto-ureteroscopy with or without balloon puncture or ureteral stenting. Additionally, 10% received interventional radiology procedures, 6.25% underwent surgical repair, and 4% underwent ultrasound-guided balloon puncture.

Conclusions:
Female gender, neurologic conditions, and long-term catheterization were identified as predominant risk factors. Early detection of ureteral cannulation can prevent severe complications, particularly in certain special populations such as patients with neurogenic bladder or SCI, who may have reduced sensation and expression capabilities.