bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using Apparent Diffusion Coefficient (ADC) of Endometrial Cancer MRI to
Determine P53 Molecular Subtypes
Authors: Zhang Feiran , Wang Tianping , Ning Yan , Li Shengyong , Chen Xiaojun , Zhang Guofu , Zhang He 
Published: April 2024

Background::
Endometrial Cancer (EC) is a highly heterogeneous cancer comprising both histological and molecular subtypes. Using a non-invasive modality
method to trigger these subtypes as early as possible can aid clinicians in establishing individualized treatment

Purpose::
The study aimed to clarify the value of the Apparent Diffusion Coefficient (ADC) of EC MRI in determining molecular subtypes.

Material and Methods::
We retrospectively recruited 109 patients with pathologically proven EC (78 endometrioid cancers and 31 non-endometrioid cancers) with
available molecular classification from a tertiary centre. MRI was prospectively performed a month prior to surgery; images were blindly
interpreted by two experienced radiologists with consensus reading. The ADC value was measured by an experienced radiologist on the
commercially available processing workstation. Interoperator measurement consistency was calculated.

Results::
Our sample comprised 17 PLOE, 32 MSI-H, 31 NSMP, and 29 P53abn ECs. Clinical information did not differ significantly among the groups.
The maximum diameter and volume of the lesions differed among the groups. The ADC value in the maximal area (ADCarea) or region of interest
(ROI, ADCroi) in the P53abn group was higher than that in the other groups (894.0 ±12.6 and 817.5 ± 83.3 x10-6 mm2/s). The ADC mean values
were significantly different between the P53abn group and the other groups (P = 0.000). The nomogram showed the highest discriminative ability
to distinguish P53abn EC from other types (AUC: 0.859).

Conclusion::
Our results have suggested the quantitative MR characteristics (ADC values) derived from preoperative EC MRI to provide useful information in
preoperatively determining P53abn cancer.
Role of Carotid Ultrasonography Combined with Monocyte/HDL Ratio in
Internal Carotid Artery Stenosis
Authors: Bao Min-qiang , Chen Yi-nong , Jin Ji-wei , Gui Dong-dong , Wang Jie , Chen Shuang-shuang , Sheng Xiao-ning , Cheng Zhang-long , Wang Yu 
Published: April 2024

Background::
Carotid duplex ultrasonography (DUS) is the primary screening tool for carotid artery stenosis, but has low reliability. MHR, which is the ratio of
monocytes to high-density lipoprotein cholesterol (HDL-C), can be a marker for the degree and distribution of extracranial and intracranial
atherosclerotic stenosis.

Objective::
We determined the diagnostic value of DUS+MHR for internal carotid artery (ICA) stenosis.

Methods::
We divided 273 hospitalized patients into non-stenosis (<50%) and ICA stenosis (≥50%) groups based on Digital Subtraction Angiography (DSA).
We determined the peak systolic velocity (PSV) in the ICA on DUS, calculated the MHR, and investigated their relationship with ICA stenosis.

Results::
On DSA, 34.1% (93/273) patients had moderate-to-severe ICA stenosis. DUS and DSA showed low concordance for detecting ICA stenosis
(kappa = 0.390). With increasing age, the incidence of moderate-to-severe ICA stenosis increased. PSV, monocyte count, and MHR were
significantly greater in the stenosis group than in the non-stenosis group (P < 0.001), while the HDL-C level was significantly lower (P = 0.001).
PSV (OR: 1.020, 95% CI: 1.011–1.029, P < 0.001) and MHR (OR: 5.662, 95% CI: 1.945–16.482, P = 0.002) were independent risk factors for
ICA stenosis. The area under the receiver operating characteristic curve of PSV+MHR (0.819) was significantly higher than that of PSV or MHR
alone (77.42% sensitivity, P = 0.0207; 73.89% specificity, P = 0.0032).

Conclusion::
The combination of ICA PSV on DUS and MHR is better than PSV alone at identifying ICA stenosis and is well-suited to screen high-risk
patients.
Computational Chemistry: Prediction of Compound Accessibility of
Targeted Synthesized Compounds
Authors: Babu Visagamoorthy , Ahmed Sumeer , Rahiman A. K. , Kawsar Sarkar M. A. , Berredjem Malika , Bhat Ajmal R. , Basha K. Anver 
Published: April 2024

Introduction:
In the present work, a series of novel pyridine carboxamides 3(a-h) were
synthesized and screened with antibacterial activity. This research explores the application of Density Functional Theory (DFT) in studying biological systems at the quantum mechanical level, particularly in the context of drug design. DFT offers a streamlined approach to quantum mechanical
calculations, making it indispensable in various scientific fields, and for its exceptional accuracy,
reduced computational time, and cost-effectiveness has become a pivotal tool in computational chemistry. This research work highlights the integration of DFT studies with POM analyses, which effectively identify pharmacophoric sites. Moreover, the research incorporates in silico pharmacokinetics
analyses to assess the pharmacokinetic properties of synthesized compounds. The paper focused on a
series of compounds previously reported, aiming to provide a comprehensive understanding of their
electronic structure, pharmacophoric features, and potential as drug candidates. This study not only
contributes to the evolving field of computational chemistry but also holds implications for advancing
drug design processes by combining theoretical insights with practical analyses.

Methods:
The compounds 3(a-h) were subjected to Density Functional Theory (DFT) computations using the B3LYP/6-31G(d) basis set to get optimized geometric structures. GaussViewis used
to display the contributions of the highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO). The determination of energy gaps was conducted using Gaussian
09W. The pharmacokinetic profiles were evaluated using existing techniques such as Osiris, Petra,
and Molinspiration, as well as a novel platform called POM Analyse

Results:
The computational studies DFT, POM and in silico pharmacokinetics studies revealed that
the studied compounds are biologically active, non-toxic, non-carcinogenic in nature and may be
utilized as drug candidates.

Conclusion:
Density functional theory (DFT) investigations emphasize the exceptional stability of
complex 3d, which possesses the biggest energy gap and the lowest softness. In contrast, compound
3h demonstrates poorer stability among the tested compounds, characterized by the lowest energy
gap and the highest softness values. These findings are further substantiated by absolute energy
calculations. The negligible energy difference in compound 3h indicates an increased transfer of
electric charge within the molecule, which is associated with its enhanced biological effectiveness.
The drug-likeness of the compounds is confirmed by POM and in silico pharmacokinetics investigations, with compound 3h being identified as the most biologically active among the investigated
compounds.
Biosynthesis and Anticancer Activity of Genistein Glycoside Derivatives
Authors: Zheng Xing , Zhang Jun , Liu Shun , Yu Yingzi , Peng Qingying , Peng Yaling , Yao Xu , Peng Xingxing , Zhou Jing 
Published: April 2024

Abstract:
As a beneficial natural flavonoid, genistein has demonstrated a wide range of biological functions
via regulating a number of targets and signaling pathways, such as anti-cancer, antioxidant, antibacterial, antiinflammatory, antifungal, antiviral, iron chelation, anti-obesity, anti-diabetes, and anti-hypertension. PubMed/Medline and Web of Science were searched using appropriate keywords until the end of December 2023.
Despite its many potential benefits, genistein’s clinical application is limited by low hydrophilicity, poor solubility, and suboptimal bioavailability due to its structure. These challenges can be addressed through the conversion of genistein into glycosides. Glycosylation of active small molecules may enhance their solubility,
stability, and biological activity. In recent years, extensive research has been conducted on the synthesis, properties, and anticancer activity of glycoconjugates. Previous reviews were devoted to discussing the biological
activities of genistin, with a little summary of the biosynthesis and the structure-activity relationship for their
anticancer activity of genistein glycoside derivatives. Therefore, we summarized recent advances in the biosynthesis of genistein glycosylation and discussed the antitumor activities of genistein glycoside derivatives in a
structure-activity relationship, which may provide important information for further development of genistein
derivatives.
Microrespirometric Validation of a Two-stage Process for Polyhydroxyalkanoates Production from Peanut Oil and Propionate with Cupriavidus necator
Authors: Pérez-Camacho Irazú , Chavarría-Hernández Norberto , del Rocío López-Cuellar Ma , Guerrero-Barajas Claudia , Ordaz Alberto 
Published: April 2024

Introduction
Poly(3-hydroxyalkanoates) (PHA) is a biodegradable polyester synthesized by various bacteria, including Cupriavidus necator. The composition of PHA is influenced by the type of microorganism, cultivation conditions, and carbon substrate. The selection of a carbon source is critical for PHA production, significantly impacting process costs. Therefore, the common goal is scalability, with the design and optimization of PHA production relying on experimental determination of constitutive parameters.

Methods
In this work, a two-stage process for PHA production was conducted in shaking flasks functioning as mini reactors with the bacteria Cupriavidus necator. During the first stage, fructose was used as the sole carbon source. Once fructose was exhausted, a second stage commenced with a new carbon source, either peanut oil or propionate, to enhance PHA production. Ex-situ pulse respirometry approach was employed during the two-stage process to follow the kinetics of substrate consumption.

Results
The results indicated that the use of peanut oil would be advantageous over propionate, resulting in 12.2% more biomass and 13.9% more PHA.

Conclusion
Additionally, the growth rate was 88.9% higher with peanut oil. The characterization by pulse respirometry applied in microreactors, i.e., micro respirometry, allowed for the performance of up to 216 biological experiments to determine four important kinetic and stoichiometric parameters, namely maximum oxygen uptake (rO2max), substrate affinity constant (KS), growth yield (YX/S), and substrate oxidation yield (YO2/S). The values of these parameters indicated that peanut oil would be the best carbon source to promote PHA production during the second stage. The implementation of the microrespirometry technique during the screening of carbon sources for PHA production provided reliable information within a short period and with significantly less experimental effort.
Loneliness, Psychological Well-being, Depression, and Social Participation
in the Older Persons: Rural and Urban Differences
Authors: Gümüş Demir Zeynep , Yılmaz Mahmut 
Published: April 2024

Introduction:
The purpose of this study is to compare the loneliness, psychological well-
being, depression, and social participation of elderly people living in Turkish society between rural
and urban areas. The sample group of the study, in which a correlational survey model was
used, consisted of 610 elderly adults.

Method:
The study population consists of two groups: the first group consists of individuals over
65 years of age living in the city (Istanbul) (n= 291), and the second group consists of individuals
over 65 years of age living in rural areas (rural areas of Ordu) (n= 319). Socio-demographic Information
Form, Loneliness in the Elderly Scale, Geriatric Depression Scale, Psychological Well-Being
in the Elderly Scale, and Social Inclusion Scale were applied online. Statistical analyses of the
study were conducted using SPSS 27.00, and the Independent Samples t-test and ANOVA test
were used.

Results:
According to the findings of this study, statistically significant results were found in psychological
well-being, social inclusion, social relations, loneliness and depression, and place of
residence. It was observed that the social isolation and social acceptance levels of those living in
urban areas were higher than those living in rural areas. Social, loneliness, and depression scores
of those living in the village/town were found to be higher than those living in the city centre. Furthermore,
the social relationship scores of those living in the village/town were found to be higher
than those living in the city centre.

Conclusion:
The increasing elderly population worldwide has become an issue that requires global
measures. Place of residence is one of the factors thought to affect older people's health and well-
being. It is thought that the study data will contribute to new policies that will ensure the protection
and promotion of elderly health and those working in this field. In addition, the study, which
provides information about Turkish culture, will also enable intercultural comparisons.
Indonesian Football: A Bibliometric Analysis and Perspectives
Authors: Pradana Mahir , Elisa Hanifah Putri , Putra Adrianza 
Published: April 2024

Background
Football is one of the most popular sports in Indonesia, where millions of people follow the game. In spite of its popularity, Indonesia has little information about the sport from the academic sector. This study gap is concerning because it limits the scholars’ ability to comprehend the effects of the sport on Indonesian society, culture, and the economy.

Methods
The formulation of plans and programs to raise the caliber and level of competition in Indonesian football is also hampered by a lack of research. In order to give some insights into how academics have so far researched Indonesian football, we undertook a bibliometric study. This article also discusses the difficulty of incorporating a sports context into the literature on social ecosystems, adding contribution by integrating ideas from previous works of literature. To get a deeper understanding of the growth of Indonesian football literature in the 2000s and 2010s, we performed a bibliometric study of football publications in several databases.

Results
The issues raised in this study will be considered in light of recent advancements in sports science, society, and technology.

Conclusion
We inferred numerous relevant subject clusters from this study, such as “training,” “competition,” and “development.” The implications of the research and its potential for future directions are also discussed in this article.
Formulation and Evaluation of Transdermal Niosomal Gel for
Antihyperlipidemic Agent
Authors: Patil Pravin , Bhagwat Priyanka , Sankpal Pournima , Patil Sachinkumar , Dhawale Shashikant 
Published: April 2024

Aims:
The current study aims to create a formulation of Fluvastatin sodium (FVS) loaded niosome
for the treatment of antihyperlipidemia using thin film hydration. The developed formulations were
statistically optimized by two factors, three levels by 3-level factorial design and were evaluated for vesicle
size, entrapment efficiency, zeta potential, transmission electron microscopy, and in-vitro drug release.

Methods:
The optimized FVS niosome being transformed to gel formulation was likewise analyzed
for in-vitro skin permeability study, lipase action, and stability study.

Results:
The composition of an improved FVS niosome revealed vesicle size, entrapment effectiveness,
zeta potential of 105.3 ± 12.4nm, 74.5 ± 0.86% and -36.2 ± 7mV, respectively, with spherical morphology.

Conclusion:
The FVS Niosomal gel demonstrated improved skin permeation compared to Orlistat. Furthermore,
lipase activity showed better activity when compared with standard Orlistat drugs. Niosomal
particles were discovered as a reliable nanovesicular carrier for the transdermal administration of FVS.
Formulation Consideration of Medicated Chewing Gum: A Review
Authors: Bobe Kishan , Suryawanshi Yoesh , Gomase Virendra , Kachhi Muizz , Bobade Chandrashekhar 
Published: April 2024

Abstract:
In recent times, technological and scientific advances have been made in studying and
developing orally delivered medication. Such studies demonstrate the importance of the oral route
among patients. The accuracy of drug delivery is very important to achieve a successful therapeutic
effect in the case of various pharmaceutical products. A novel drug delivery system adds new benefits
or advantages to a drug. This review covers all the aspects of medicated chewing gum (MCG)
as a new drug delivery method, including the benefits and drawbacks, manufacturing methods, type
of MCG, composition of chewing gum, evaluation parameters, factors that affected the release of
API, its pharmaceutical significance, various marketed chewing gum and chewing gum packaging.
Chewing gum as a drug delivery system has the potential to cure or prevent various indications,
such as analgesic, CNS stimulation, smoking cessation, motion sickness, and treatment and prevention
of dental caries or gingivitis. Pharmaceutical distribution to the oral mucosa can be made more
convenient and enticing with the help of MCG. Compared to conventional techniques, this delivery
system has a longer-lasting effect, which makes it a viable option for treating digestive problems,
headaches, migraines, coughing, anxiety, and allergies.
Boutique Library Characteristics and Social Media Marketing as a Moderator in Fostering Sustainability in Malaysian Boutique Libraries
Authors: Abd Rahman Shaeiddah Akmar , Husaini Haslinda , Ong Chris Siew Har , Mazlan Mazwani Ayu 
Published: April 2024

Inspecting Malaysian boutique libraries and their environment, focusing on unique traits and social media marketing as a sustainability tool. This study underlines the need to understand Malaysian boutique libraries' specific qualities and survival. The study focuses on qualitative literature surveys, content analysis, and case studies. After reviewing boutique library literature, promotional materials, goal statements, and a few Malaysian boutique libraries' websites are examined, and the report emphasises Malaysian boutique libraries' key traits. This study also investigates how social media marketing can help boutique libraries survive. Social media helps boutique libraries reach their target audience, promote their services, and establish a community.
Taxonomy Development of PTAR Local Content Collections: A critical analysis of the expert-assigned and LCSH subject headings
Authors: Mustafa A’dillah , A. Wahid Eza Eliana , Rosli Noredayu , Abdullah Mawar Noor 
Published: April 2024

Developing a taxonomy for local content collection is a massive challenge for librarians which involves understanding the complexity of a particular subject classification. This paper aims to report the analysis of the taxonomy developed for the Sports Science & Recreational compared to Library of Congress Subject Headings (LCSH). The analysis employs subject analysis as the methodology for comparing expert-assigned keywords with LCSH. The analysis found 6 divisions in the local content compared to only 2 divisions in LCSH, and 364 subjects compared to only 98 in LCSH. The percentage of terms categories includes exact terms used (14%), similar terms used (11%), and not used terms (97%).
Remote Foot Temperature Monitoring Among Veterans: Large Observational Study of Noncompliance and Its Correlates
Authors: Littman Alyson J , Timmons Andrew K , Korpak Anna , Chan Kwun C G , Jones Kenneth T , Shirley Suzanne , Nordrum Kyle , Robbins Jeffrey , Masadeh Suhail , Moy Ernest 
Published: April 2024

Abstract

Background
In-home remote foot temperature monitoring (RTM) holds promise as a method to reduce foot ulceration in high-risk patients with diabetes. Few studies have evaluated adherence to this method or evaluated the factors associated with noncompliance.

Objective
The aims of this study were to estimate noncompliance in patients who were enrolled in RTM nationwide across Department of Veterans Affairs (VA) and to evaluate characteristics associated with noncompliance.

Methods
We conducted an observational study including 1137 patients in the VA who were enrolled in RTM between January 2019 and June 2021, with follow-up through October 2021. Patient information was obtained from the VA’s electronic health record and RTM use was obtained from the company. Noncompliance was defined as using the mat <2 days per week for ≥4 of the 12 months of follow-up. Using a multivariable model, we calculated odds ratios (ORs) and 95% CIs for associations between various factors and noncompliance and compared using Akaike information criterion statistics, a measure of model fit.

Results
The sample was predominantly male (n=1125, 98.94%) ; 21.1% (n=230) were Black and 75.7% (n=825) were White. Overall, 37.6% (428/1137) of patients were classified as noncompliant. In the multivariable model, an intermediate area deprivation index was statistically significantly and inversely associated with noncompliance (area deprivation index 50‐74 vs 1‐24; OR 0.56, 95% CI 0.35-0.89); factors significantly and positively associated with noncompliance included recent history of osteomyelitis (OR 1.44, 95% CI 1.06-1.97), Gagne comorbidity index score ≥4 (vs ≤0; OR 1.81, 95% CI 1.15-2.83), telehealth encounters (28+ vs <6; OR 1.70, 95% CI 1.02-2.84), hemoglobin A1c≥10 (vs <5.7; OR 2.67, 95% CI 1.27-5.58), and current smoking (OR 2.06, 95% CI 1.32-3.20). Based on Akaike information criterion differences, the strongest factors associated with noncompliance were behavioral factors (poor glucose control [as measured by hemoglobin A1c] and smoking), and to a lesser extent, factors such as a recent history of osteomyelitis and an elevated Gagne comorbidity index, indicating a high comorbidity burden.

Conclusions
To reduce the risk of ulcer recurrence and amputation, proactively providing additional support for self-monitoring to patients with characteristics identified in this study (poor glucose control, current smoking, high comorbidity burden) may be helpful. Furthermore, research is needed to better understand barriers to use, and whether the addition of design features, reminders, or incentives may reduce noncompliance and the risk of foot ulcers.