bluuebunny/crossref_metadata_2025_split huggingface dataset:
High frequency of fibromyalgia in patients with chronic fatigue seen in a primary care practice
Authors: Goldenberg Don L. , Simms Robert W. , Geiger Ann , Komaroff Anthony L. 
Published: February 2007

AbstractWe administered a standardized history questionnaire and performed a tender point examination on 27 patients with debilitating fatigue of at least 6 months duration, seen in a primary care practice, as well as on 20 patients with fibromyalgia. Sixteen of the 27 patients with chronic fatigue met the full criteria for the working case definition of chronic fatigue syndrome (CFS). Eight patients with chronic fatigue denied having any current persistent, diffuse musculoskeletal pain, and their tender point scores were similar to those in 10 normal control subjects. In contrast, 19 patients with chronic fatigue (70%) had persistent, diffuse musculoskeletal pain. The results of their tender point examinations were similar to those of the patients with fibromyalgia. Thus, the majority of these patients with debilitating chronic fatigue, including those who met criteria for CFS, met the historical and tender point diagnostic criteria for fibromyalgia. The presence of current musculoskeletal pain will identify those CFS patients who have fibromyalgia.
Synovitis in angioimmunoblastic lymphadenopathy with dysproteinemia simulating rheumatoid arthritis
Authors: Boumpas Dimitrios T. , Wheby Munsey S. , Jaffe Elaine S. , Steinberg Alfred D. , Klippel John H. , Balow James E. 
Published: February 2007

AbstractWe describe a patient with angioimmunoblastic lymphadenopathy with dysproteinemia who developed a symmetric, rheumatoid‐like, peripheral polyarthritis. Radiographs of the involved joints revealed soft tissue swelling without erosions or cartilage loss. Rheumatoid factor and fluorescent antinuclear antibodies were negative, and C‐reactive protein and erythrocyte sedimentation rate were normal. Synovial fluid analysis showed an inflammatory effusion (white blood cell count of 3,500/mm3, with 76% polymorphonuclear leukocytes). A closed synovial biopsy of the wrist revealed a mononuclear infiltrate consistent with angioimmunoblastic lymphadenopathy with dysproteinemia. Monthly parenteral chemotherapy treatment with high‐dose methyl‐prednisolone and cyclophosphamide resulted in remission of all manifestations of disease, including arthritis.
Early‐onset primary osteoarthritis and mild chondrodysplasia
Authors: Katzenstein Paul L. , Malemud Charles J. , Pathria Mini N. , Carter John R. , Sheon Robert P. , Moskowitz Roland W. 
Published: February 2007

AbstractThree generations of a nonconsanguineous family with premature onset of primary (idiopathic) osteoarthritis (OA) were studied for clues to the etiopathogenesis of their disorder. Articular symptoms began in their second and third decades of life and involved multiple joints, both typical and atypical for primary OA. Radiographs of the majority of involved peripheral joints showed abnormalities typical of primary OA. Evidence of chondrodysplasia was found in the spines. Pathologic examination of femoral heads obtained at total hip arthroplasty from 3 affected family members showed moderate to severe OA. Articular cartilage proteoglycans from these specimens were evaluated for aggregatability with hyaluronic acid, levels of chondroitin sulfate and keratan sulfate, and core protein structure. The results from each patient's specimen differed from the results of the other specimens. We conclude that this family's disorder, primary OA associated with a mild chondrodysplasia, was a late‐onset overlap form of an epiphyseal dysplasia, that a defect common to hyaline articular and physeal cartilage was primary, and that a single structural proteoglycan abnormality was not likely to be the underlying cause.
Detection of serum antibodies to retroviral proteins in patients with primary sjögren's syndrome (autoimmune exocrinopathy)
Authors: Talal Norman , Dauphinée Michael J. , Dang Howard , Alexander Steve S. , Hart Darrenn J. , Garry Robert F. 
Published: February 2007

AbstractPrimary Sjögren's syndrome (SS) is considered a benign autoimmune disease; it is characterized by lymphoid infiltration of salivary and lacrimal glands, often accompanied by the presence of serum autoantibodies, particularly anti‐Ro (SS‐A) and anti‐La (SS‐B). There are important immunologic similarities between primary SS and acquired immunodeficiency syndrome. To investigate for a possible immune response to retroviral proteins in primary SS, we performed immunoblotting against human immunodeficiency virus‐1 (HIV‐1) proteins using sera from 47 patients with primary SS. Moderate‐to‐strong reactivity, suggesting the presence of serum antibodies, was found in 14 patients (30%). Of 120 normal subjects, only 1 showed moderate positivity. All 14 positive SS sera reacted against p24 (gag) but failed to react against gp41 or gp120 (env). This response did not reflect hypergammaglobulinemia since immunoglobulin concentrations among the 29 SS patients studied were the same in sera that contained and sera that did not contain anti‐gag reactivity. Two sera also reacted against p17 gag. Four reacted against HIV‐2 core proteins, but none reacted with core proteins of human T lymphotropic virus‐I. Only 1 of the 14 sera reacted against Ro (SS‐A), and 1 other reacted against La (SS‐B). These results identify a subset of SS patients characterized by 1) the presence of serum antibodies to HIV‐1 group‐specific, but not type‐specific, proteins, and 2) the relative absence of anti‐Ro (SS‐A) and anti‐La (SS‐B) autoantibodies. In this latter respect, these SS patients constitute a subpopulation that resembles patients with HIV‐induced SS‐like disease.
The expression of C3b receptors in the differentiation of discoid lupus erythematosus and systemic lupus erythematosus
Authors: Tausk Francisco , Harpster Elaine , Gigli Irma 
Published: February 2007

AbstractWe studied the expression of the C3b receptor, CR1, on erythrocytes (E‐CR1) of patients who, in spite of having mild systemic symptoms, were diagnosed as having discoid lupus erythematosus and followed accordingly. We found that E‐CR1 was markedly reduced in these patients, similar to that seen in patients with systemic disease. In contrast, those patients with completely asymptomatic discoid lupus erythematosus had the same expression of E‐CR1 as the normal population.
Association of l‐tryptophan and an illness resembling eosinophilic fasciitis: clinical and histopathologic findings in four patients with eosinophilia‐myalgia syndrome
Authors: Bulpitt Ken J. , Verity M. Anthony , Clements Philip J. , Paulus Harold E. 
Published: February 2007

AbstractThe Centers for Disease Control has recently reported an association between the use of oral L‐tryptophan preparations and a disease marked by severe myalgia, peripheral eosinophilia, and neuromuscular and cutaneous abnormalities. They have labeled the condition eosinophilia‐myalgia syndrome. We report here the clinical and histopathologic findings in 4 patients who developed an illness resembling eosinophilic fasciitis following the initiation of oral L‐tryptophan supplementation.
The in vitro effects of methotrexate on peripheral blood mononuclear cells: Modulation by methyl donors and spermidine
Authors: Nesher Gideon , Moore Terry L. 
Published: February 2007

AbstractThe mode of action of low‐dose methotrexate (MTX) in rheumatoid arthritis (RA) is unclear. The effects of MTX are mediated primarily through inhibition of dihydrofolate reductase, resulting in a dose‐dependent inhibition of purine and pyrimidine synthesis. Other folate‐dependent metabolic pathways might be secondarily affected. One such pathway is the regeneration of methionine from homocysteine, with subsequent formation of the methyl donor S‐adenosylmethionine (SAM) and polyamines, which are important in cell‐mediated immune reactions. To assess whether MTX inhibits SAM and polyamine synthesis in lymphocytes, pokeweed mitogen‐stimulated mononuclear cells from healthy donors were incubated with MTX. This resulted in decreased proliferation and IgG, IgM, and IgM rheumatoid factor synthesis. However, addition of folinic acid, methionine, SAM, or spermidine resulted in reversal of the MTX‐mediated inhibition. These data suggest that MTX inhibits the folate‐dependent pathway of methionine regeneration, thereby inhibiting SAM and polyamine synthesis. Since RA lymphocytes have increased concentrations of polyamines, the beneficial effects of MTX in RA may be related to its potential ability to reduce polyamine synthesis.
Antibody to signal recognition particle in polymyositis
Authors: Targoff Ira N. , Johnson Arthur E. , Miller Frederick W. 
Published: February 2007

AbstractUsing immunoprecipitation, we identified 13 patients with antibodies to the signal recognition particle (SRP) from a collection of sera representing 265 poly‐myositis/dermatomyositis (PM/DM) patients. Antibody reactivity with SRP was confirmed by enzyme‐linked immunosorbent assay and immunoprecipitation with isolated dog pancreas SRP. The antibody was present in the serum of 4% of PM/DM patients, and 18% of PM/ DM patients with anticytoplasmic antibodies other than anti‐Jo‐1, but not in patients with other conditions who had anticytoplasmic antibodies. Anti‐SRP was associated with classic adult PM, and some of these cases were unusually severe and/or of rapid onset; it was not found in patients with overlap syndromes or with DM involvement. Unlike patients with antibodies to aminoacyl‐transfer RNA synthetases, patients with anti‐SRP had a low frequency of pulmonary fibrosis, as well as of arthritis and Raynaud's phenomenon. Anti‐SRP antibodies may serve as a marker for a second, distinct subgroup of adult PM.
Cartilage proteoglycan‐induced arthritis in BALB/c mice. Antibodies that recognize human and mouse cartilage proteoglycan and can cause depletion of cartilage proteoglycan with little or no synovitis
Authors: Dayer Eric , Mathai Lalitha , Glant T. T. , Mikecz K. , Poole A. Robin 
Published: February 2007

AbstractHuman fetal cartilage proteoglycan (PG) induces the development of an erosive polyarthritis and spondylitis in BALB/c mice. We have examined the properties of 3 monoclonal antibodies (MAb) to human fetal cartilage PG isolated from immunized mice that cross‐react with mouse cartilage PG. Compared with sera from arthritic mice, which contain antibodies reactive with keratan sulfate, MAb 202 (IgG1) reacted only with a protein‐related epitope that is distributed on both hyaluronic acid‐binding and chondroitin sulfate‐attachment regions. MAb 813 (IgG1) reacted with the same fragments and recognized an epitope with the immunologic characteristics of keratan sulfate. MAb 945 (IgM) remains to be further characterized. Introduction of hybridomas secreting MAb 202 and MAb 945 into irradiated mice resulted in the loss of PG from articular cartilage and from growth plate cartilage (with MAb 202 only), as revealed by a loss of staining with toluidine blue. There was no synovial hyperplasia with MAb 202, but some hyperplasia and mononuclear cell infiltration was seen with MAb 945. This was accompanied by the binding of immunoglobulins to articular cartilage, as demonstrated by immunofluorescence. The hybridoma secreting MAb 813 produced no cartilage changes or synovitis, and there was no immunoglobulin binding to cartilage. Polymorphonuclear leukocyte infiltration was never observed with these antibodies. These studies indicate that MAb reactive with mouse cartilage PG can cause the depletion of PG from hyaline cartilage by mechanisms that may be both complement dependent and complement independent. Antibodies may serve to release and expose PG antigen to immune cells, as well as causing a loss of the mechanical properties of cartilage that are PG dependent.
Binding of anti‐DNA antibodies and inhibition of glomerulonephritis in MRL‐lpr/lpr mice by heparin
Authors: Naparstek Yaakov , Ben‐Yehuda Arie , Madaio Michael P. , Bar‐Tana Ruth , Schuger Lucy , Pizov Galina , Neeman Zvi , Cohen Irun R. 
Published: February 2007

AbstractHeparin was found to inhibit the DNA binding of antibodies eluted from kidneys of both humans and MRL‐lpr/lpr mice with systemic lupus erythematosus. Treatment of MRL‐lpr/lpr mice with low doses of heparin significantly inhibited renal damage. These results suggest that low‐dose heparin might be useful in preventing renal damage in patients with lupus nephritis.
Human immunodeficiency virus‐associated psoriasis, psoriatic arthritis, and Reiter's syndrome: A disease continuum?
Authors: Reveille John D. , Conant Marcus A. , Duvic Madeleine 
Published: February 2007

AbstractThe presence of peripheral arthritis and HLA‐A, B, C, DR, and DQ antigens was evaluated prospectively in 18 Caucasian men with human immunodeficiency virus‐associated psoriasis. An asymmetric polyarthritis occurred in 32% of the patients and correlated with the presence of HLA‐B27. Extensive clinical overlap between psoriatic arthritis, psoriasis, and Reiter's syndrome was noted. No significant excess of the HLA antigens previously found to be associated with psoriasis was seen, which suggests that human immunodeficiency virus‐associated psoriasis per se may instead constitute another form of spondylarthropathy that is more closely related to Reiter's syndrome.
Intravenous pulse cyclophosphamide therapy in myositis and Sjögren's syndrome
Authors: Leroy J. P. , Drosos A. A. , Yiannopoulos D. I. , Youinou P. , Moutsopoulos H. M. 
Published: February 2007

AbstractWe describe a patient with primary Sjögren's syndrome who developed myositis. The results of muscle pathologic analysis before and after treatment with monthly pulses of cyclophosphamide (intravenously), are presented.
Interleukin‐1‐induced interleukin‐6 is required for the inhibition of proteoglycan synthesis by interleukin‐1 in human articular cartilage
Authors: Nietfeld J. J. , Wilbrink B. , Helle M. , Roy J. L. A. M. Van , Otter W. Den , Swaak A. J. G. , Huber‐Bruning O. 
Published: February 2007

AbstractCartilage from normal controls, patients with osteoarthritis, and patients with rheumatoid arthritis produced no interleukin‐6 (IL‐6) in culture. However, IL‐1 induced massive production of IL‐6 (up to 135 ng/ml) in cartilage from all 3 sources, in a dose‐dependent manner (in some cases, a peak value was reached). The levels of induced IL‐6 were similar to those found in rheumatoid arthritis synovial fluid. At IL‐1 concentrations that induced almost complete inhibition of proteoglycan (PG) synthesis, IL‐6 production could still be increased considerably. Exogenous IL‐6 inhibited PG synthesis by up to 25%. IL‐1‐induced inhibition of PG synthesis was reversed by antibodies against recombinant human IL‐6. These results suggest that IL‐6 is required for the IL‐1‐induced inhibition of PG synthesis.
Pregnancy and the risk of developing rheumatoid arthritis
Authors: Hazes J. M. W. , Dijkmans B. A. C. , Vandenbroucke J. P. , Vries R. R. P. De , Cats A. 
Published: February 2007

AbstractThere have been conflicting reports on, and no plausible biologic explanation for, a protective effect of oral contraceptive (OC) use on the development of rheumatoid arthritis (RA). Therefore, we investigated aspects of behavior related to OC use that could explain the preventive effect of OC on the onset of RA. In the present case—control study, past pregnancy, age at first pregnancy, and pregnancies with adverse outcome were studied as possible risk factors for RA. Interview information on reproductive variables was obtained from 135 young adult women with confirmed definite or classic RA of recent onset, and from 378 control patients with soft tissue rheumatic disorders or osteoarthritis. All patients had at least 2 years of followup to confirm the consistency of the diagnosis. We found a decreased risk of RA in women who had been pregnant. The risk of RA in women who had ever been pregnant compared with women who had never been pregnant was 0.49 (95% confidence interval 0.27–0.91). The earlier the first pregnancy, the lower the risk of RA. Pregnancy with adverse outcome (i.e., gestation <25 weeks) did not substantially change the risk of RA (relative risk 0.73, 95% confidence interval 0.50–1.07). The protective effect of pregnancy was independent of OC use, the presence of HLA–DR4, or a family history of RA. Immune modulation by female hormonal influences could be an explanation for the results of the present study.
Role of cytokines in inflammatory synovitis
Authors: Chin Jia En , Winterrowd Greg E. , Krzesicki Raymond F. , Sanders Martin E. 
Published: February 2007

AbstractThis study was undertaken in an effort to understand the role of cytokines in T lymphocyte trafficking into inflamed synovium and in the potential enhancement of antigen presentation by human synovial fibroblasts. We found that interleukin‐1β (IL‐1β), tumor necrosis factor α (TNFα), and interferon‐γ (IFNγ) each increased the cell surface expression of intercellular adhesion molecule 1 (ICAM‐1) on human synovial fibroblasts in a dose‐ and time‐dependent manner. Maximal ICAM‐1 expression occurred within 8 hours of induction, with the following order of efficacy: IFNγ > TNFα > IL‐1β. The number of cells bearing the ICAM‐1 antigen also increased, from a basal level of ∼30% to more than 83% after cytokine induction (for all 3 cytokines). ICAM‐1 expression rapidly decreased following cytokine removal. The expression of lymphocyte function‐associated antigen 3 was also examined, but it was not changed by any of the 3 cytokines. Class I major histocompatibility complex antigen expression was increased modestly by all 3 cytokines, and expression was maximal by 24 hours after treatment. Only IFNγ induced HLA class II antigen expression, and this expression persisted for up to 6 days following removal of the lymphokine. IL‐6 and granulocyte‐macrophage colony‐stimulating factor had no effect on any of the parameters examined. Our data support an interactive role for inflammatory cytokines and the expression of adhesion ligands and HLA antigens by human synovial fibroblasts in the pathogenesis of synovial inflammation in rheumatoid arthritis.
Antihistone antibodies in antinuclear antibody—positive juvenile Arthritis
Authors: Monestier Marc , Losman Julie A. , Fasy Thomas M. , Debbas Michael E. , Massa Margherita , Albani Salvatore , Bohm Lothar , Martini Alberto 
Published: February 2007

AbstractThe binding of antinuclear antibody—positive juvenile arthritis (JA) sera to bovine thymus histones H1, H2A, H2B, H3, and H4 was studied by an enzyme‐linked immunosorbent assay. Seventy‐five percent of the JA patients tested positive for at least 1 antibody specificity. Antihistone antibodies were predominantly IgM, while IgG antibodies were less common and were restricted to histones H1 or H3. In the group of patients with JA of pauciarticular onset, antihistone antibodies were significantly more elevated in patients with past or present uveitis than in patients without a history of uveitis. Anti‐H1 antibodies in JA patients were found to react mostly with determinants located in the carboxylterminal domain of the H1 molecule. Sera were also reactive with human histone H1° or chicken histone H5, which are H1 variants found only in nondividing cells.
Adrenal insufficiency in two women with anticardiolipin antibodies
Authors: Levy Ernesto N. , Ramsey‐Goldman Rosalind , Kahl Leslie E. 
Published: February 2007

AbstractWe describe 2 women with anticardiolipin antibodies and a lupus‐like disorder who developed acute adrenal insufficiency. We also review 5 similar cases reported previously. Anticardiolipin antibodies appear to be a risk factor for this vascular complication.
Increased expression of intercellular adhesion molecule 1 on the fibroblasts of scleroderma patients
Authors: Needleman Barbara White 
Published: February 2007

AbstractThe surface expression of intercellular adhesion molecule 1 (ICAM‐1) and class I and class II major histocompatibility complex molecules on cultured dermal fibroblasts from 7 scleroderma patients and 6 control donors was compared. Scleroderma fibroblast lines contained 41.0 ± 3.0% (mean ± SEM) cells with high levels of ICAM‐1 expression (ICAM‐1—high), whereas 26.9 ± 1.5% of control fibroblasts were ICAM‐1—high (P = 0.0003). There were no differences in the expression of class I and class II molecules. ICAM‐1—high and ICAM‐1—low fibroblasts produced equal amounts of total protein and procollagen. The increase in the number of ICAM‐1—high fibroblasts in scleroderma patients may facilitate T cell activation and lymphokine production, and thus indirectly contribute to the fibrotic process.
Double‐blind, placebo‐controlled study of three‐month treatment with lymecycline in reactive arthritis, with special reference to Chlamydia arthritis
Authors: Lauhio Anneli , Leirisalo‐Repo Marjatta , Lähdevirta Juhani , Saikku Pekka , Repo Heikki 
Published: February 2007

AbstractWe conducted a double‐blind, placebo‐controlled, randomized study of 3‐month treatment with lymecycline, a form of tetracycline, in reactive arthritis (ReA). Lymecycline therapy significantly decreased the duration of the illness in patients with Chlamydia trachomatis‐triggered ReA, but not in other ReA patients. In 2 ReA patients, C trachomatis was found in the throat, an uncommon locale for this organism. Our results suggest that it is important to verify the triggering microbe and that it is beneficial to treat Chlamydia arthritis patients with a prolonged course of tetracycline.
Chondrons from articular cartilage. III. Morphologic changes in the cellular microenvironment of chondrons isolated from osteoarthritic cartilage
Authors: Poole C. Anthony , Matsuoka Akira , Schofield Jennifer R. 
Published: February 2007

AbstractChondrons were isolated from human and canine osteoarthritic cartilage using low‐speed homogenization techniques. Changes in chondron morphology were evaluated using differential interference–contrast microscopy, phase‐contrast microscopy, and histochemical and ultrastructural methods. Chondrocyte viability was assessed using fluorescein diacetate staining, and chondron metabolism was investigated using autoradiography. The results suggest that initial changes in the collagen and proteoglycan distribution within the chondron are followed by chondrocyte proliferation to form clusters. These techniques offer the potential to study cell matrix interactions in degenerative osteoarthritis.
Induction of arthritis in rats by aqueous suspensions of mycobacteria without the use of oil
Authors: Levine Seymour , Saltzman Arthur 
Published: February 2007

AbstractWe report for the first time the induction of arthritis by an aqueous, rather than an oil, suspension of killed tubercle bacilli. This was accomplished in the highly susceptible dark Agouti strain of rats, by intraperitoneal injection during the healing phase of chemically induced peritonitis. The same procedure (injection after the induction of peritonitis) augmented the incidence of arthritis produced by bovine type II collagen and Freund's complete adjuvant. Enhanced delivery of antigen from the peritoneal cavity to regional lymph nodes in the postinflammatory state was responsible for this increase in the induction of arthritis.
Complete heart block and severe aortic incompetence in relapsing polychondritis: Clinicopathologic findings
Authors: Bowness Paul , Hawley Ian C. , Morris Tom , Dearden Andrew , Walport Mark J. 
Published: February 2007

AbstractWe describe a patient with relapsing polychondritis who developed fatal cardiac involvement comprising complete heart block, acute aortic incompetence, and cardiovascular collapse. Pathologic studies showed fibrosis of the cardiac conducting system and necrotizing inflammation of the aortic valve, features not previously described in relapsing polychondritis, as well as evidence of coronary artery vasculitis.