bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endoscopic outcomes using a novel through-the-scope tack and suture system for gastrointestinal defect closure: a systematic review and meta-analysis
Authors: Canakis Andrew , Deliwala Smit S. , Frohlinger Michael , Twery Benjamin , Canakis Justin P. , Shaik Mohammed Rifat , Gunnarsson Erik , Ali Osman , Dahiya Dushyant Singh , Gorman Emily , Irani Shayan S. , Baron Todd H. 
Published: March 2024

Abstract
Background Closure of gastrointestinal defects can reduce postprocedural adverse events. Over-the-scope clips and an over-the-scope suturing system are widely available, yet their use may be limited by defect size, location, operator skill level, and need to reinsert the endoscope with the device attached. The introduction of a through-the-scope helix tack suture system (TTSS) allows for closure of large irregular defects using a gastroscope or colonoscope, without the need for endoscope withdrawal. Since its approval 3 years ago, only a handful of studies have explored outcomes using this novel device.
Methods Multiple databases were searched for studies looking at TTSS closure from inception until August 2023. The primary outcomes were the success of TTSS alone and TTSS with clips for complete defect closure. Secondary outcomes included complete closure based on procedure type (endoscopic mucosal resection [EMR], endoscopic submucosal dissection [ESD]) and adverse events.
Results Eight studies met the inclusion criteria (449 patients, mean defect size 34.3 mm). Complete defect closure rates for TTSS alone and TTSS with adjunctive clips were 77.2% (95%CI 66.4–85.3; I2=79%) and 95.2% (95%CI 90.3–97.7; I2=42.5%), respectively. Complete defect closure rates for EMR and ESD were 99.2% (95%CI 94.3–99.9; I2 = 0%) and 92.1% (95%CI 85–96; I2=0%), respectively. The adverse event rate was 5.4% (95%CI 2.7–10.3; I2=55%).
Conclusion TTSS is a novel device for closure of postprocedural defects, with relatively high technical and clinical success rates. Comparative studies of closure devices are needed.
Rapid Cyclic Acetal and Cyclic Ketal Synthesis Assisted by a Rotary Evaporator
Authors: Jiang Fuyao , Chen Yinzhe , Zhang Qian , Wang Weiding 
Published: March 2024

AbstractHerein, we present a rapid and efficient method for synthesizing cyclic acetals and ketals utilizing a rotary evaporator. Unlike the conventional Dean–Stark dehydration process, which typically demands extended reaction times and copious amounts of organic solvents, our approach affords the synthesis of cyclic acetals and ketals with varying ring sizes in 30 min while using minimal quantities of dimethyl sulfoxide as the solvent. This innovative protocol features high yields, fast reactions, easy operation, and broad substrate applicability.
Granular Cell Tumor of the Breast: Understanding the Cancer Mimic through a Series of Three Cases
Authors: Sharma Swati , Shah Aanchal , Sharma Smita 
Published: March 2024

AbstractGranular cell tumors of breast are rare neoplasms, majority of which are benign. Their imaging appearances are often indistinguishable from breast cancer. They may demonstrate a few differentiating features and unlike breast cancer, typically follow a benign course. Histopathology and immunochemistry form the cornerstone of diagnosis of granular cell tumor. In this article, we presented a series of three cases of granular cell tumors with variable presentations. Our goal is to increase familiarity for these neoplasms and for the readers to be able to distinguish them from the more common entity of breast cancer, as their prognosis and management differ.
Thrombus-Demarcated Stenting with Dual-Contrast Imaging: A Novel Approach for Late-ST-Segment Elevation Myocardial Infarction with Unsuccessful Predilatation
Authors: Oguz Mustafa , Akbulut Tayyar , Saylik Faysal , Cinar Tufan 
Published: March 2024

AbstractThe success of revascularization in the total occluded coronary lesion with dense thrombus burden is important for the short- and long-term prognosis of patients with acute ST-segment elevation myocardial infarction (STEMI). In these lesions, stenting without dispersing the thrombus can increase the success of revascularization without fatal complications. The aim of this case is to demonstrate the newly developed thrombus-demarcated stenting with dual-contrast imaging approach after unsuccessful predilatation in a late-inferior STEMI. In centers where optical coherence tomography is not available, this technique can be used as an alternative.
The influences of adult and child speakers in the emergence of
Light Warlpiri, an Australian mixed language
Authors: O’Shannessy Carmel 
Published: March 2024

Abstract
Many analyses of language change are only able to
draw on data from adult speech and therefore cannot empirically
motivate a connection between an origin of a potential change and
the actuation of that change throughout a community of speakers. The
case study of the recent emergence of Light Warlpiri (O’Shannessy 2005), a mixed
language spoken in northern Australia, provides new perspectives on
the roles of different age groups of adults and children in the
emergence of the mixed language, and suggests an empirically
motivated model of how a mixed language can emerge from practices of
code-switching between languages, in a two-stage process (O’Shannessy 2020). This
case also has important implications for the sociohistorical study
of the potential role of young learners in other cases of language
change and the emergence of new languages.
Language dominance across the lifespan in Wisconsin German and
English varieties
Authors: Litty Samantha M. 
Published: March 2024

Abstract
Large-scale German immigration to Wisconsin
began in the first half of the 19th century and continued until
about World War I. These immigrants built German-speaking
institutions alongside English and other immigrant language
institutions, allowing for the presence of German in many Wisconsin
communities over several generations, along with a desire to
preserve local history and heritage in the region. These practices
are reflected in an archival record that allows for the study of
features of local German and English over a period of 150 years.
This chapter focuses on two such features, namely variation of voice
onset time and final obstruent neutralization. A combination of
historical written sources (spanning between the 1860s and the
1940s) and audio recordings from the 1940s and 2013 shows the
existence of these features, as well as different periods along
their development over time. This study looks at how language
acquisition in heritage language communities and shifts in language
dominance may have played a role in the emergence and development of
these features in Wisconsin German and Wisconsin English
varieties.
Early modern manuscripts containing Old English dictionaries in England and northern Germany
Authors: Vollbrecht Melanie 
Published: March 2024

Abstract
This paper retraces the early modern beginnings of systematic Old English studies in England and continental
Europe. It shows that linguistic study was born out of research interests in the fields of theology, law, and local
history to name but a few; and that scholars needed dictionaries as tools to understand this archaic form of English.
In the 16th century, John Joscelyn and John Parker created a substantial dictionary of Old English, of which several
Northern German copies exist today. This paper explores the production processes of Joscelyn/Parker’s dictionary as
well as the Northern German copies, as can be gleaned from the similarities and, more importantly, the differences in
layout, entry-count and -content, and marginal markings in the manuscripts.
Loss of wiþer-words in English
Authors: Sylwanowicz Marta , Wojtyś Anna 
Published: March 2024

Abstract
The element wiþer is documented in Old English as a separate lexeme and a prefix.
Altogether, Bosworth-Toller’s An Anglo-Saxon Dictionary records 69 wiþer-lexemes,
which implies that wiþer- was relatively productive and flexible. Generally, wiþer-
was added to words with the sense of ‘against’; in rare cases, it denoted ‘in return or compensation’ and ‘in the
opposite direction’ (OED). Curiously, the majority of wiþer-lexemes are not recorded
in Middle English: merely 24 words occur in MED. The aim of this study is to account for the loss of
wiþer-lexemes. Potential causes are linguistic, such as low frequency and the similarity of the
prefix wiþer- to wiþ-, and extra-linguistic, including competition with foreign
items and changes in pragmatic associations of the words.
“Grammar, I hate” or “I grammar hate”?
Authors: Han Weifeng 
Published: March 2024

Abstract
Cross-module interfaces, such as the syntax-semantics interface, are among the most problematic properties to fully acquire in a second language (L2). First language (L1) monodialectal and bidialectal speakers may show different performances at the interfaces in L2. However, little is known if such a different performance is caused by learners’ diverse L1 dialectal backgrounds. The study is motivated by the need to link speech-language pathology and word order typological studies in a bidialectal/bilingual context. The aim is to investigate L1 bidialectism in the L2 syntax-semantics interface acquisition outcome and to separate language difference from language disorder. A sentence-picture matching task on the topic-comment structure was administered among 37 Mandarin monodialectal and 39 Mandarin – Wu bidialectal child speakers. Results of a generalized linear model showed that L1 bidialectals exhibited better syntactic-semantic awareness in L2 than their L1 monodialectal counterparts. The results showed that mono- and bidialectal speakers have different performance patterns at the syntax-semantics interface involving noncanonical word orders for L2. However, the L2 performance was under the impact of language difference between L1 and L2, it does not qualify for Developmental Language Disorder (DLD). Finally, the study offers both theoretical and clinical implications for the diagnosis and assessment of bilingual DLD.
Explaining gender
Authors: Fuchs Zuzanna , Polinsky Maria , Scontras Gregory 
Published: March 2024

Abstract
This work examines the knowledge of grammatical gender by bilingual speakers for whom Spanish is the weaker language in the dyad, that is, heritage speakers of Spanish. In modeling heritage speakers’ knowledge and use of grammatical gender, we distinguish between gender assignment (how nouns get associated with specific genders) and gender agreement (the process by which features of a noun get shared by other sentential constituents). We show that divergent instances of gender assignment constitute the use of a default strategy; with masculine as the default class in Spanish, the absence of gender assignment surfaces as masculine morphology. We also review evidence suggesting that heritage speakers differ from the baseline in relying on surface gender cues more categorically. To explain the intricacies of divergent agreement behavior, we argue for genuine representational difference between how baseline and heritage speakers represent gender (and number) features. Taken together, these observations indicate that heritage speakers are sensitive to cues for gender assignment despite the decreased input they receive compared to baseline speakers; their assignment strategies then translate into the observed patterns of agreement, which as a syntactic phenomenon is alive and well in the heritage grammar. We use our results to highlight the utility of non-lexicalist approaches to the representation of gender.
Meaning without borders
Authors: Cope Bill , Kalantzis Mary , Tzirides Anastasia Olga (Olnancy) 
Published: March 2024

Abstract
“Translanguaging” is a concept that connects with older traditions of analysis in linguistics and practices in language pedagogy, while at the same time making some distinctions that justify the creation of a new word. This chapter begins by tracing roots of the idea of translanguaging in its intellectual predecessors and affiliates: code switching, translation, bilingualism, multilingualism, hybridity, and multiliteracies. In the sections that follow, we set out to extend the terms of this discussion by introducing another concept, “transposition,” designed to cast the net wider than language and capturing the restless fluidity of multiform meaning making between and across text, image, space, object, body, sound and speech. From here, we go on to explore the implications of a transpositional analysis for varieties of pedagogical practice in learning another language. Next, we use this frame of analysis to explore the characteristic features of digital media. These precipitate a renewed urgency to reconsider the terms of our theoretical discussions and pedagogical practices. They also raise challenges, at once deeply concerning and potentially productive, for the job of language teaching and its professional practices. The chapter concludes by addressing pedagogy, and in particular the development of an extended repertoire of practice for another language learning in the era of digitally-mediated meanings. This returns us to theme of the chapter, “meaning without borders,” or the project of supplementing traditional analyses of meaning-through-language with a widened repertoire of pedagogical practice for language teachers.
Effect of rifampicin on TLR4-signaling pathways in the nucleus accumbens of the rat brain during abstinence of long-term alcohol treatment
Authors: Airapetov Marat , Eresko Sergei , Ignatova Polina , Lebedev Andrei , Bychkov Evgenii , Shabanov Petr 
Published: March 2024

Abstract

Aims
The treatment with the antibiotic rifampicin (Rif) led to a decrease in the frequency of neurodegenerative pathologies. There are suggestions that the mechanism of action of Rif may be mediated by its effect on toll-like receptor (TLR)4-dependent pathways. We evaluated the expression status of TLR4-dependent genes during abstinence from long-term alcohol treatments in the nucleus accumbens (NAc) of the rat brain, and also studied the effects of Rif to correct these changes.

Methods
The long-term alcohol treatment was performed by intragastric delivery of ethanol solution. At the end of alcohol treatment intraperitoneal injections of Rif (100 mg/kg) or saline were made. Extraction of the brain structures was performed on the 10th day of abstinence from alcohol. We used the SYBR Green qPCR method to quantitatively analyze the relative expression levels of the studied genes.

Results
The long-term alcohol treatment promotes an increase in the level of TLR4 mRNA and mRNA of its endogenous ligand high-mobility group protein B1 during abstinence drop alcohol in NAc of rats. The use of Rif in our study led to a decrease in the increased expression of high-mobility group protein B1, Tlr4, and proinflammatory cytokine genes (Il1β, Il6) in the NAc of the rat brain during abstinence of long-term alcohol treatment. In addition, Rif administration increased the decreased mRNA levels of anti-inflammatory cytokines (Il10, Il11).

Conclusion
The data obtained indicate the ability of Rif to correct the mechanisms of the TLR4 system genes in the NAc of the rat brain during alcohol abstinence.
Digital Neuropsychology beyond Computerized Cognitive Assessment: Applications of Novel Digital Technologies
Authors: Harris Che , Tang Yingfei , Birnbaum Eliana , Cherian Christine , Mendhe Dinesh , Chen Michelle H 
Published: March 2024

Abstract
Compared with other health disciplines, there is a stagnation in technological innovation in the field of clinical neuropsychology. Traditional paper-and-pencil tests have a number of shortcomings, such as low-frequency data collection and limitations in ecological validity. While computerized cognitive assessment may help overcome some of these issues, current computerized paradigms do not address the majority of these limitations. In this paper, we review recent literature on the applications of novel digital health approaches, including ecological momentary assessment, smartphone-based assessment and sensors, wearable devices, passive driving sensors, smart homes, voice biomarkers, and electronic health record mining, in neurological populations. We describe how each digital tool may be applied to neurologic care and overcome limitations of traditional neuropsychological assessment. Ethical considerations, limitations of current research, as well as our proposed future of neuropsychological practice are also discussed.
Neurocognitive Impairment in Post-COVID-19 Condition in Adults: Narrative Review of the Current Literature
Authors: Garmoe William , Rao Kavitha , Gorter Bethany , Kantor Rachel 
Published: March 2024

Abstract
The severe acute respiratory syndrome coronavirus 2 virus has, up to the time of this article, resulted in &gt;770 million cases of COVID-19 illness worldwide, and approximately 7 million deaths, including &gt;1.1 million in the United States. Although defined as a respiratory virus, early in the pandemic, it became apparent that considerable numbers of people recovering from COVID-19 illness experienced persistence or new onset of multi-system health problems, including neurologic and cognitive and behavioral health concerns. Persistent multi-system health problems are defined as Post-COVID-19 Condition (PCC), Post-Acute Sequelae of COVID-19, or Long COVID. A significant number of those with PCC report cognitive problems. This paper reviews the current state of scientific knowledge on persisting cognitive symptoms in adults following COVID-19 illness. A brief history is provided of the emergence of concerns about persisting cognitive problems following COVID-19 illness and the definition of PCC. Methodologic factors that complicate clear understanding of PCC are reviewed. The review then examines research on patterns of cognitive impairment that have been found, factors that may contribute to increased risk, behavioral health variables, and interventions being used to ameliorate persisting symptoms. Finally, recommendations are made about ways neuropsychologists can improve the quality of existing research.
MoCoLo: a testing framework for motif co-localization
Authors: Xu Qi , del Mundo Imee M A , Zewail-Foote Maha , Luke Brian T , Vasquez Karen M , Kowalski Jeanne 
Published: March 2024

Abstract
Sequence-level data offers insights into biological processes through the interaction of two or more genomic features from the same or different molecular data types. Within motifs, this interaction is often explored via the co-occurrence of feature genomic tracks using fixed-segments or analytical tests that respectively require window size determination and risk of false positives from over-simplified models. Moreover, methods for robustly examining the co-localization of genomic features, and thereby understanding their spatial interaction, have been elusive. We present a new analytical method for examining feature interaction by introducing the notion of reciprocal co-occurrence, define statistics to estimate it and hypotheses to test for it. Our approach leverages conditional motif co-occurrence events between features to infer their co-localization. Using reverse conditional probabilities and introducing a novel simulation approach that retains motif properties (e.g. length, guanine-content), our method further accounts for potential confounders in testing. As a proof-of-concept, motif co-localization (MoCoLo) confirmed the co-occurrence of histone markers in a breast cancer cell line. As a novel analysis, MoCoLo identified significant co-localization of oxidative DNA damage within non-B DNA-forming regions that significantly differed between non-B DNA structures. Altogether, these findings demonstrate the potential utility of MoCoLo for testing spatial interactions between genomic features via their co-localization.
Interleukin-6 supplementation improves bovine conceptus elongation and transcriptomic indicators of developmental competence
Authors: Speckhart Savannah L , Oliver Mary A , Keane Jessica A , Dias Nicholas W , Mercadante Vitor R G , Biase Fernando H , Ealy Alan D 
Published: March 2024

Abstract
A high incidence of pregnancy failures occurs in cattle during the second week of pregnancy as blastocysts transition into an elongated conceptus. This work explored whether interleukin-6 supplementation during in vitro embryo production would improve subsequent conceptus development. Bovine embryos were treated with 0 or 100 ng/mL recombinant bovine interleukin-6 beginning on day 5 post-fertilization. At day 7.5 post-fertilization, blastocysts were transferred into estrus synchronized beef cows (n = 5 recipients/treatment, 10 embryos/recipient). Seven days after transfer (day 14.5), cows were euthanized to harvest reproductive tracts and collect conceptuses. Individual conceptus lengths and stages were recorded before processing for RNA sequencing. Increases in conceptus recovery, length, and the proportion of tubular and filamentous conceptuses were detected in conceptuses derived from interleukin-6-treated embryos. The interleukin-6 treatment generated 591 differentially expressed genes in conceptuses (n = 9–10/treatment). Gene ontology enrichment analyses revealed changes in transcriptional regulation, DNA-binding, and antiviral actions. Only a few differentially expressed genes were associated with extraembryonic development, but several differentially expressed genes were associated with embryonic regulation of transcription, mesoderm and ectoderm development, organogenesis, limb formation, and somatogenesis. To conclude, this work provides evidence that interleukin-6 treatment before embryo transfer promotes pre-implantation conceptus development and gene expression in ways that resemble the generation of a robust conceptus containing favorable abilities to survive this critical period of pregnancy.
Pharmacokinetic Analysis of Two N-Substituted Rosmarinic Acid Analogs in Rat Plasma by Liquid Chromatography-Tandem Mass Spectrometry
Authors: Fu Shujie , Zhang Qinglang , Zhang Shiyu , Jiang Weizhe , Jiang Minjie 
Published: March 2024

Abstract
This study reports the development of an effective high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method for the quantification of two analogs of rosmarinic acid (RA) in rat plasma, namely methyl (E)-2-(3-(3,4-difluorophenyl)acrylamido)-3-(3,4-dihydroxyphenyl)propanoate (A11) and methyl (E)-3-(3,4-dihydroxyphenyl)-2-(3-(3,4-dihydroxyphenyl)acrylamido)propanoate (A2). These analogs, featuring N atoms instead of O atoms, exhibit enhanced bioavailability and distinct pharmacological activities compared with RA. The HPLC separation was carried out on a C18 column (1.9 μm, 2.1 mm × 100 mm) coupled with a security guard C18 column (5 μm, 2.1 mm × 10 mm). A triple-quadrupole mass spectrometer equipped with an electrospray ionization ion source was utilized for ion generation. Pseudoephedrine hydrochloride was utilized as a standard, and a single-step protein precipitation method using isopropanol:ethyl acetate (v/v, 20:80) was employed for sample pretreatment. The developed method demonstrated excellent linearity over the concentration range of 5–750 ng/ml for both A11 and A2, with relative standard deviations of &lt;15% and relative errors within 15% during daily course analysis. The method allowed for the unambiguous quantification and identification of A11 and A2 in vivo. The results of this study provide a meaningful foundation for evaluating the clinical applications of these analogs.