bluuebunny/crossref_metadata_2025_split huggingface dataset:
An advance in novel intelligent sensory technologies: From an implicit‐tracking perspective of food perception
Authors: Zhao Qian , Ye Zhiyue , Deng Yong , Chen Jin , Chen Jianle , Liu Donghong , Ye Xingqian , Cheng Huan 
Published: March 2024

AbstractFood sensory evaluation mainly includes explicit and implicit measurement methods. Implicit measures of consumer perception are gaining significant attention in food sensory and consumer science as they provide effective, subconscious, objective analysis. A wide range of advanced technologies are now available for analyzing physiological and psychological responses, including facial analysis technology, neuroimaging technology, autonomic nervous system technology, and behavioral pattern measurement. However, researchers in the food field often lack systematic knowledge of these multidisciplinary technologies and struggle with interpreting their results. In order to bridge this gap, this review systematically describes the principles and highlights the applications in food sensory and consumer science of facial analysis technologies such as eye tracking, facial electromyography, and automatic facial expression analysis, as well as neuroimaging technologies like electroencephalography, magnetoencephalography, functional magnetic resonance imaging, and functional near‐infrared spectroscopy. Furthermore, we critically compare and discuss these advanced implicit techniques in the context of food sensory research and then accordingly propose prospects. Ultimately, we conclude that implicit measures should be complemented by traditional explicit measures to capture responses beyond preference. Facial analysis technologies offer a more objective reflection of sensory perception and attitudes toward food, whereas neuroimaging techniques provide valuable insight into the implicit physiological responses during food consumption. To enhance the interpretability and generalizability of implicit measurement results, further sensory studies are needed. Looking ahead, the combination of different methodological techniques in real‐life situations holds promise for consumer sensory science in the field of food research.
Fasting as a precursor to high‐fat diet enhances mitochondrial resilience in Drosophila melanogaster
Authors: Hunter‐Manseau Florence , Cormier Simon B. , Strang Rebekah , Pichaud Nicolas 
Published: March 2024

AbstractChanges in diet type and nutrient availability can impose significant environmental stress on organisms, potentially compromising physiological functions and reproductive success. In nature, dramatic fluctuations in dietary resources are often observed and adjustments to restore cellular homeostasis are crucial to survive this type of stress. In this study, we exposed male Drosophila melanogaster to two modulated dietary treatments: one without a fasting period before exposure to a high‐fat diet and the other with a 24‐h fasting period. We then investigated mitochondrial metabolism and molecular responses to these treatments. Exposure to a high‐fat diet without a preceding fasting period resulted in disrupted mitochondrial respiration, notably at the level of complex I. On the other hand, a short fasting period before the high‐fat diet maintained mitochondrial respiration. Generally, transcript abundance of genes associated with mitophagy, heat‐shock proteins, mitochondrial biogenesis, and nutrient sensing pathways increased either slightly or significantly following a fasting period and remained stable when flies were subsequently put on a high‐fat diet, whereas a drastic decrease of almost all transcript abundances was observed for all these pathways when flies were exposed directly to a high‐fat diet. Moreover, mitochondrial enzymatic activities showed less variation after the fasting period than the treatment without a fasting period. Overall, our study sheds light on the mechanistic protective effects of fasting prior to a high‐fat diet and highlights the metabolic flexibility of Drosophila mitochondria in response to abrupt dietary changes and have implication for adaptation of species to their changing environment.
Evaluation of the effectiveness of using prednisolone, tacrolimus, and intravenous immunoglobulin combination therapy on immune‐mediated necrotizing myopathy—A non‐randomized, observational research
Authors: Liu Mengyang , Liu Jiaqi , Li Ke , Qiao Lingya , Chen Juan , Lin Ying , Shi Qiang 
Published: March 2024

AbstractObjectiveTo recruit immune‐mediated necrotizing myopathy (IMNM) patients with extramuscular manifestations who were refractory to initial therapy with either monotherapy with prednisolone or dual therapy with prednisolone and immunosuppressants. These patients subsequently received a combination of prednisolone, tacrolimus, and intravenous immunoglobulin (IVIG), and the efficacy of this treatment regimen was assessed in patients with IMNM.Method①Clinical data and treatment measures are as follows: This study enrolled IMNM patients who were treated at the Neurology Department of the First Medical Center of PLA General Hospital from April 2020 to May 2023. These patients received a combination therapy of prednisolone, tacrolimus, and IVIG. ②Observational indicators included manual muscle test for 8 groups of muscles (MMT‐8), muscle enzyme levels (creatine kinase (CK), lactate dehydrogenase (LDH), alanine aminotransferase (ALT), aspartate aminotransferase (AST)), and myositis disease activity assessment tool (MDAAT).ResultsThis study enrolled eight patients. All observational indicators declined after treatment compared to before treatment, and these changes were statistically significant. Moreover, extramuscular manifestations also ameliorated compared to before treatment.ConclusionThe combination therapy of prednisolone, tacrolimus, and IVIG has demonstrated favorable efficacy in IMNM and broadened the treatment options for this disease. However, the results still require further validation by large‐scale and randomized controlled studies.
Look after the COVID‐19 pandemic: Mortality rates among patients with rheumatic diseases
Authors: Çimen Güneş Ezgi , Çolak Seda , Şenlik Zeynep B. , Tekgöz Emre , Altunay Kerime , Özdemirkan Tuğba , Aytaç Baran C. , Şimşek Asiye Ç. , Çınar Muhammet , Yılmaz Sedat 
Published: March 2024

AbstractAimSevere Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2) infection may have a more severe course in patients with underlying disease or who have had immunosuppression. In this study, it was aimed to determine the frequency of coronavirus disease 2019 (COVID‐19) and the mortality rates related to COVID‐19 among patients with rheumatic disease.MethodsThe patients who were followed up with rheumatic disease in the rheumatology outpatient clinic in a tertiary hospital were retrospectively assessed if they had COVID‐19 infection or not between March 2020 and January 2022.ResultsA total of 10 682 patients were evaluated. There were 2928 (27.4%) COVID‐19‐positive and 7754 (72.6%) COVID‐19‐negative patients. The mean age of COVID‐19‐positive patients was 46.2 ± 14.6 years, and 65.8% were female. Forty‐two (1.4%) patients died due to COVID‐19. Among COVID‐19‐negative patients, 192 patients died. The most common rheumatic disease among patients with COVID‐19 was spondyloarthritis (SpA) (30.4%). Corticosteroids were the most common treatment agent in COVID‐19‐positive patients regardless of mortality. Thirty‐one (73.8%) patients were receiving corticosteroids, and 35 (83.3%) patients were receiving immunosuppressive agents among patients with mortality. According to the logistic regression analysis, older age, male gender, and receiving corticosteroid, hydroxychloroquine, mycophenolate mofetil, tofacitinib, rituximab, and cyclophosphamide were found to be related to increased mortality.ConclusionCOVID‐19 is a serious infection and the current study emphasized that patients with rheumatic diseases had increased mortality rates, particularly in patients who were old, male, and on immunosuppressive treatments.
Navigating occupational digitalization via skillshed analysis
Authors: Jolley G. Jason , Bone Clara , Bacot Hunter , Pham Tuyen 
Published: March 2024

AbstractThe rapid digitalization of jobs in the United States and globally provides both an economic opportunity and a challenge for upskilling and reskilling the workforce. Retraining and reintegrating displaced or at‐risk workers, particularly in a competitive labor market, brings significant economic benefits to communities, employers, and employees. Individuals in at‐risk or declining occupations likely lack requisite digital literacy and associated skills that enable them to transition smoothly into roles that require digital proficiency. Drawing from research indicating the rapid digitalization of the U.S. economy and workforce, this study employs skillshed analysis to examine a sample of vulnerable occupations within coal‐related industries. The goal is to evaluate training gaps and wage differentials for individuals shifting from coal‐related occupations to roles requiring higher levels of digital literacy. Providing quality reemployment options for coal‐economy workers reduces the barriers to transitioning to more sustainable energy provision, yet prior studies have found that coal‐economy workers possess lower levels of digital literacy. Our study reaffirms these prior findings that many coal economy workers lack the requisite knowledge, training, and educational attainment to easily transition to occupations requiring high degrees of digitalization. As a result, to be successful in retraining and upskilling those in coal‐related occupations and to meet sustainable development goals, it is necessary to assist these workers in their transition into viable occupations.
Doing good is not equal to good people: The wealth‐based gap in prosocial motive attributions
Authors: Wang Yan , Zheng Haoyue , Tang Wanlin , Liu Bingjie , Zhang Zhen 
Published: March 2024

AbstractAre attributions of motives for prosocial behaviour modulated by the actor's wealth? We provide evidence for people attributing higher reputational motives to rich prosocial actors than poor ones across four studies. This effect persists across different kinds of prosocial behaviours, including helping (Study 1), volunteering (Study 2), and donating money (Studies 3–4). Furthermore, rich (vs. poor) prosocial actors are perceived to be less likely to be driven by altruistic motives and to have lower moral character than poor actors (Studies 2–3). Attribution of reputational motives and altruistic motives mediates the effect of target wealth on the perception of moral character (Study 2–3). Study 4 demonstrates that the judgement gap disappears when reputational benefits are implausible: voluntary privacy eliminates the wealth‐based gap in motive attributions and judgement of moral character. These findings highlight that suspicion of motives prevents people from giving credit to rich prosocial actors. The implications for understanding motive inferences and prosocial credit are also discussed.
Novel growth reference ImaGrow differed from existing charts for preterm children aged 0–2 years
Authors: Tuková Jana , Kosek Krásničanová Hana , Hladíková Marie , Marková Daniela 
Published: March 2024

AbstractAimThis study aimed to address the critical need for more accurate growth reference charts for preterm infants, with a particular focus on low‐ and very low‐birth‐weight infants.MethodsThe subjects were recruited at a single tertiary centre. The cohort comprised singleton and twin infants born before 37 weeks of gestation, with data collected from 2000 to 2016. Standardised measurements of body parameters were recorded in this mixed longitudinal survey. LMS method was utilised for data analysis. Statistical analysis was performed using SPSS Statistics Version 21. The validation with another new cohort was executed.ResultsA total of 1781 infants (52.5% boys) met the inclusion criteria. The median gestational age at birth was 30 weeks, with a median birth weight of 1350 grams. The main findings included the construction of ImaGrow charts for low‐ and very low‐birth‐weight infants and significant differences in growth trajectories compared to Fenton+WHO charts.ConclusionOur comprehensive growth references, ImaGrow, are based on a long‐term auxological assessment of preterm infants and differ from charts derived from size‐at‐birth standards or charts for term babies. These charts have significant implications for clinical practice in monitoring and assessing the growth of preterm infants.
BRCA1 deficiency enhances the aggressiveness of breast cancer cells expressing HPV16 oncoproteins
Authors: Sangthong Jariya , Thuwajit Chanitra , Jensen Laran T. , Komyod Waraporn , Yuvaniyama Jirundon , Ponglikitmongkol Mathurose 
Published: March 2024

AbstractBackground InformationThe precise etiology of breast cancer is not completely understood, although women with BRCA1 gene mutations have a significantly increased risk of developing the disease. In addition, sporadic breast cancer is frequently associated with decreased BRCA1 gene expression. Growing evidence of Human papillomaviruses (HPVs) infections in breast tumors has raised the possibility of the involvement of HPVs in the pathogenesis of breast cancer. We investigated whether the effects of HPV oncoproteins E6 and E7 were influenced by the expression levels of BRCA1. HPV16E6E7 (prototype or E6D25E/E7N29S Asian variant type) were stably expressed in MDA‐MB231 breast cancer cells, wild type for BRCA1, or with BRCA1 knocked down.ResultsExpression of HPV16E6E7 oncogenes did not affect BRCA1 levels and the abundance of HPV16E6E7 was not altered by BRCA1 knockdown. BRCA1 levels did not alter HPV16E6E7‐dependent degradation of G1‐S cell cycle proteins p53 and pRb. However, we found that the expression of G2‐M cell cycle protein cyclin B1 enhanced by HPV16E6E7 was impacted by BRCA1 levels. Especially, we found the correlation between BRCA1 and cyclin B1 expression and this was also confirmed in breast cancer samples from a Thai cohort. We further demonstrated that the combination of HPV oncoproteins and low levels of BRCA1 protein appears to enhance proliferation and invasion. Transactivation activities of HPV16E6E7 on genes regulating cell proliferation and invasion (TGF‐β and vimentin) were significantly increased in BRCA1‐deficient cells.ConclusionsOur results indicate that a deficiency of BRCA1 promotes the transactivation activity of HPV16E6E7 leading to increase of cell proliferation and invasion.SignificanceHPV infection appears to have the potential to enhance the aggressiveness of breast cancers, especially those deficient in BRCA1.
Innovative pharmacotherapy for hepatic metabolic and chronic inflammatory diseases in China
Authors: Zhang Feng , Ju Jiaming , Diao Hongtao , Song Jinglun , bian Yu , Yang Baofeng 
Published: March 2024

AbstractLiver disease constitutes a significant global health concern, particularly in China where it has distinctive characteristics. China grapples with a staggering 300 million cases, predominantly due to hepatitis B and metabolic non‐alcoholic fatty liver disease. Additionally, hepatocellular carcinoma has become a prevalent which is a lethal type of cancer. Despite the scarcity of innovative treatment options, Chinese hepatologists and researchers have achieved notable breakthroughs in the prevention, diagnosis, management and treatment of liver diseases. Traditional Chinese medicines have found widespread application in the treatment of various liver ailments owing to their commendable pharmacological efficacy and minimal side effects. Furthermore, there is a growing body of research in extracellular vesicles, cell therapy and gene therapy, offering new hope in the fight against liver diseases. This paper provides a comprehensive overview of the epidemiological characteristics of liver diseases and the diverse array of treatments that Chinese scholars and scientists have pursued in critical field.
Does intra‐oral scan improve the impression accuracy of full‐arch implant‐supported prostheses: A systematic review and meta‐analysis
Authors: Cai Zheng‐zhen , Li Xin , Wu Xin‐Yu , Lai Hong‐Chang , Shi Jun‐Yu 
Published: March 2024

AbstractObjectivesThe present study aimed to systematically review the studies comparing the accuracy of intraoral scan (IOS) and conventional implant impressions (CI) in completely edentulous patients.Materials and MethodsElectronic searches were performed in PubMed, Embase and Cochrane CENTRAL up to December 1, 2023. Clinical studies and in vitro studies reporting the accuracy of digital full arch impressions were included. The primary outcome is the 3‐dimensional deviations between the study reference models. A risk of bias assessment was performed for clinical studies. A stratified meta‐analysis and a single‐armed meta‐analysis were conducted.ResultsA total of 49 studies were included, with 8 clinical studies and 41 in vitro studies. For comparison between IOS and conventional impressions, studies were categorized into two groups based on the different measurement methods employed: RMS and CMM. In studies using RMS, the result favored the IOS in the unparalleled situation with the mean difference of −99.29 μm (95% CI: [−141.38, −57.19], I2 = 81%), while the result was opposite with the mean difference of 13.62 μm (95% CI: [10.97, 16.28], I2 = 26%) when implants were paralleled. For different brands of IOS, the accuracy ranged from 76.11 μm (95% CI: [42.36, 109.86]) to 158.63 μm (95% CI: [−14.68, 331.93]).ConclusionsAccuracy of intraoral scan is clinically acceptable in edentulous arches, especially for unparalleled implants. More clinical studies are needed to verify the present finding.
Mismatch between conservation higher education skills training and contemporary conservation needs
Authors: Slater Helena , Fisher Janet , Holmes George , Keane Aidan 
Published: March 2024

AbstractScholars have detailed the range of skills required for conservation and voiced concerns that training is not fit for purpose. Still, we have little understanding of what skills conservation education aims to teach. This study uses survey data and content analysis of online module descriptions to examine skills and methods teaching in conservation higher education across the United Kingdom and Australia. We found most conservation‐specific modules aimed to develop disciplinary and communication skills, but fewer than half aimed to develop interpersonal or project management skills. Social science methods training was absent from the core offering of over half of the conservation degrees reviewed. To prepare students for conservation careers and the complex problems they will encounter, the conservation education sector should further focus on building essential nonacademic skills and provide training on the breadth of methods that contribute to effective conservation science. This analysis can help educators to reflect on teaching aims and forge a curriculum that will best prepare students for contemporary conservation challenges.
Impact of OPTN policy 3.7D providing waiting time modification for candidates affected by race‐inclusive eGFR calculations: Early results from a single center
Authors: Hoffman Arika L. , Westphal Scott G. , Wekesa Debra , Miles Clifford D. 
Published: March 2024

AbstractIntroductionOPTN Policy 3.7D, implemented January 5, 2023, mandates that all kidney transplant programs modify waiting time for candidates affected by race‐inclusive eGFR calculations. We report the early impact of this policy change.MethodsOur transplant program reviewed all listed transplant candidates and identified patients potentially eligible for waiting time modification. Eligible candidates received waiting time modification after submission of supporting evidence to the OPTN. We reviewed the impact on waiting time and transplant activity through October 1, 2023.ResultsForty‐six adult patients on our center's active waiting list self‐identified as Black/African American. 25 (54.3%) candidates qualified for waiting time modification. A median 451 (321, 1543.5) additional days of waiting time was added for qualifying patients. Of the 25 patients who qualified for waiting time modification, 11 patients received a deceased donor kidney in the early period following waiting time modification, including 5 patients transplanted within 1 month after modification.ConclusionsPolicy 3.7D is one of few national mandates to address specifically structural racism within transplantation. Implementation has yielded near immediate effects with greater than 40% of time‐adjusted patients at our center receiving a deceased donor kidney transplant in the initial months after policy enactment. Early assessment demonstrates great potential impact for this policy.
New insight of chemical constituents in Persea americana fruit against obesity via integrated pharmacology
Authors: Cha Min‐Gi , Lee Su‐Been , Yoon Sang‐Jun , Lee Sang Youn , Gupta Haripriya , Ganesan Raja , Sharma Satya Priya , Won Sung‐Min , Jeong Jin‐Ju , Kim Dong Joon , Oh Ki‐Kwang , Suk Ki‐Tae 
Published: March 2024

AbstractPersea americana fruit (PAF) is a favorable nutraceutical resource that comprises diverse unsaturated fatty acids (UFAs). UFAs are significant dietary supplementation, as they relieve metabolic disorders, including obesity (OB). In another aspect, this study was focused on the anti‐OB efficacy of the non‐fatty acids (NFAs) in PAF through network pharmacology (NP). Natural product activity & species source (NPASS), SwissADME, similarity ensemble approach (SEA), Swiss target prediction (STP), DisGeNET, and online Mendelian inheritance in man (OMIM) were utilized to gather significant molecules and its targets. The crucial targets were adopted to construct certain networks: protein–protein interaction (PPI), PAF‐signaling pathways‐targets‐compounds (PSTC) networks, a bubble chart, molecular docking assay (MDA), and density function theory (DFT). Finally, the toxicities of the key compounds were validated by ADMETlab 2.0 platform. All 41 compounds in PAF conformed to Lipinski's rule, and the key 31 targets were identified between OB and PAF. On the bubble chart, PPAR signaling pathway had the highest rich factor, suggesting that the pathway might be an agonism for anti‐OB. Conversely, estrogen signaling pathway had the lowest rich factor, indicating that the mechanism might be antagonism against OB. Likewise, the PSTC network represented that AKT1 had the greatest degree value. The MDA results showed that AKT1‐gamma‐tocopherol, PPARA‐fucosterol, PPARD‐stigmasterol, (PPARG)‐fucosterol, (NR1H3)‐campesterol, and ILK‐alpha‐tocopherol formed the most stable conformers. The DFT represented that the five molecules might be promising agents via multicomponent targeting. Overall, this study suggests that the NFAs in PAF might play important roles against OB.