bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment and factors affecting quality of life among patients with Wilson’s disease
Authors: Zhan Tingting , Guan Yuxiang , Sun Caijie , Wang Lili , Wang Yan , Li Xiang 
Published: April 2024

AbstractWilson’s disease is caused by abnormal copper metabolism resulting in deposition in various organs, including the brain, liver, and cornea, thus disrupting organ function. It is characterized by encephalopathy, extrapyramidal symptoms, progressive liver failure, and copper ring deposition in the cornea. Management of this disease should include quality of life maintenance; however, relevant studies on this topic are lacking. This study aimed to assess the factors affecting the quality of life (QoL) of patients with Wilson’s disease. A cross-sectional survey using convenience sampling was conducted between July 2020 and March 2021 at the hospital. Data on patient characteristics, 36-item Short-Form General Health Survey, Uniform Wilson Disease Rating Scale, and Hamilton Depression Rating Scale scores were collected. Associations among quality of life depression, anxiety, and Wilson’s disease progression were examined using Pearson correlation analysis. Factors affecting the quality of life of patients, including depression, anxiety, liver function, clinical symptoms, diet, liver function, brain magnetic resonance imaging (MRI) findings, disease duration, Barthel Index, and Morse scores were examined using multivariate linear regression analysis. This study included 134 patients with Wilson’s disease whose mean age was 29.12 ± 8.59 years. The mean QoL score in the patient group was 71.38 ± 9.55 points and was negatively correlated with anxiety (r = − 0.883, P = 0.000), depression (r = − 0.852 P = 0.000), and clinical symptoms (r = − 0.542, P = 0.000) scores. Anxiety, depression, and clinical symptoms severity are vital factors for the QoL of patients with Wilson’s disease. The study provides foundational evidence to design novel interventions, including symptom management, diet, and self-care ability, which can help in improving the quality of life in patients with Wilson’s disease and decreasing the burden associated with this disease.
Zyxin is important for the stability and function of podocytes, especially during mechanical stretch
Authors: Kliewe Felix , Siegerist Florian , Hammer Elke , Al-Hasani Jaafar , Amling Theodor Rolf Jakob , Hollemann Jonas Zeno Eddy , Schindler Maximilian , Drenic Vedran , Simm Stefan , Amann Kerstin , Daniel Christoph , Lindenmeyer Maja , Hecker Markus , Völker Uwe , Endlich Nicole 
Published: April 2024

AbstractPodocyte detachment due to mechanical stress is a common issue in hypertension-induced kidney disease. This study highlights the role of zyxin for podocyte stability and function. We have found that zyxin is significantly up-regulated in podocytes after mechanical stretch and relocalizes from focal adhesions to actin filaments. In zyxin knockout podocytes, we found that the loss of zyxin reduced the expression of vinculin and VASP as well as the expression of matrix proteins, such as fibronectin. This suggests that zyxin is a central player in the translation of mechanical forces in podocytes. In vivo, zyxin is highly up-regulated in patients suffering from diabetic nephropathy and in hypertensive DOCA-salt treated mice. Furthermore, zyxin loss in mice resulted in proteinuria and effacement of podocyte foot processes that was measured by super resolution microscopy. This highlights the essential role of zyxin for podocyte maintenance in vitro and in vivo, especially under mechanical stretch.
An abundant bacterial phylum with nitrite-oxidizing potential in oligotrophic marine sediments
Authors: Zhao Rui , Jørgensen Steffen L. , Babbin Andrew R. 
Published: April 2024

AbstractNitrite-oxidizing bacteria (NOB) are important nitrifiers whose activity regulates the availability of nitrite and dictates the magnitude of nitrogen loss in ecosystems. In oxic marine sediments, ammonia-oxidizing archaea (AOA) and NOB together catalyze the oxidation of ammonium to nitrate, but the abundance ratios of AOA to canonical NOB in some cores are significantly higher than the theoretical ratio range predicted from physiological traits of AOA and NOB characterized under realistic ocean conditions, indicating that some NOBs are yet to be discovered. Here we report a bacterial phylum Candidatus Nitrosediminicolota, members of which are more abundant than canonical NOBs and are widespread across global oligotrophic sediments. Ca. Nitrosediminicolota members have the functional potential to oxidize nitrite, in addition to other accessory functions such as urea hydrolysis and thiosulfate reduction. While one recovered species (Ca. Nitrosediminicola aerophilus) is generally confined within the oxic zone, another (Ca. Nitrosediminicola anaerotolerans) additionally appears in anoxic sediments. Counting Ca. Nitrosediminicolota as a nitrite-oxidizer helps to resolve the apparent abundance imbalance between AOA and NOB in oxic marine sediments, and thus its activity may exert controls on the nitrite budget.
Interactive low delay music and speech communication via network connections (OVBOX)
Authors: Grimm Giso 
Published: April 2024

The “OVBOX” is a tool for low-delay network audio communication and generic data transmission between multiple clients. Acoustic end-to-end delays of about 30 ms can be achieved, assuming a good internet connection and a distance between clients of less than about 1500 km. For optimal spatial perception, e.g., when using multiple instruments of similar timbre, an individual 3-dimensional room acoustic simulation based on physical modelling is applied in each client. The system is optimised for headless operation using a dedicated single-board computer (Raspberry Pi 4B), but desktop clients are also available for better integration with other audio software. A client-server system allows remote configuration and automatic traversal of network address translation routers and firewalls. With the low latency that can be achieved, the “OVBOX” is used for music applications such as distributed rehearsals or concerts. Other applications include hearing research to achieve interactive speech communication with low delay transmission of head movements for real-time control of virtual reality, and transmission of other biophysical data for online analysis or central data logging. The tool is fully open source.
Immune responses of sea cucumber (Apostichopus japonicus) to combined environmental stress from high temperature and oil pollution
Authors: Ju Zhonglei , Li Xishan , Yang Wei , Xiong Deqi 
Published: April 2024

Context High temperature and oil pollution are typical examples of environmental stress to sea cucumber (Apostichopus japonicus) in northern China. Aims Evaluate the combined effects of high temperature and oil pollution on the immune responses of sea cucumbers. Methods In this study, we investigated the immune responses in the respiratory tree of sea cucumber subjected to the optimal temperature (16°C), high temperature (26°C), Oman crude oil (OCO) water-accommodated fractions (WAF) at 16°C (WAF + 16°C) and OCO WAF at 26°C (WAF + 26°C) for 48 h. Key results All three treatments significantly up-regulated total antioxidant capacity and disturbed active oxygen species homeostasis in sea cucumbers. Moreover, all three treatments caused immune-enzyme activity disorders, manifested by a significant increase in acid–alkaline phosphatase and nitric oxide synthase activities and a noticeable decline in lysozyme activity. Conclusions Combining the integrated biomarker-response index (WAF + 26°C > 26°C > WAF + 16°C), the combined stress could result in a more adverse effect on the immune responses of sea cucumbers than do high temperature or oil pollution alone, which might further exacerbate the health challenges for sea cucumbers in response to environmental stress. Implications This study has provided an insight into the immune impacts in benthic organisms caused by high temperature and oil pollution.
Phenological and life-history responses of a tropical cladoceran Moina micrura to multiple environmental drivers
Authors: Razak Muhammad Raznisyafiq , Aris Ahmad Zaharin , Zaki Muhammad Rozaimi Mohd , Yusoff Fatimah Md , Yusof Zetty Norhana Balia 
Published: April 2024

Context Climate change and global warming has led to changes in water-quality parameters, which in turn have negative consequences for zooplankton. Aims To investigate the effects of various environmental stressors (pH, temperature, photoperiod, and food concentration) on the tropical freshwater microcrustacean Moina micrura. Methods The study examined the effects of these stressors on survival (lifespan), reproduction (days to first brood, number of broods, and total offspring), growth (individual size and total moulting), physiology (heart rate), and sex-switching effects (total male offspring). Key results Significant (P < 0.05) reductions in the total offspring, individual size, and heart rate of M. micrura were observed when exposed to acidic (pH 5) and alkaline (pH 9) conditions. Conversely, higher water temperatures (31°C) and longer light exposure (20 h) were found to increase total offspring and heart rate in M. micrura. Furthermore, male offspring were produced only under conditions of food scarcity (no food supply and 1 × 102 cells mL−1). Conclusions Climate change has a significant effect on the life-history traits of M. micrura, a tropical cladoceran species. Implications Vital insights that can guide policymakers and practitioners in developing more effective strategies to safeguard and preserve tropical freshwater aquatic habitats, especially those of zooplankton species.
Improving the size selectivity of crayfish fyke-net codend, applying the hexagonal mesh and sorting grid
Authors: Cilbiz Mehmet , Aydın Celalettin 
Published: April 2024

Context Owing to the use of fyke-nets with poor size selectivity in crayfish fishery, 40.7% of the landed undersized catch is discarded as bycatch. Aims This study investigated the effects of using hexagonal mesh (Hex34) instead of diamond nets (Com34) in the traditional crayfish fyke-net and the application of a sorting-grid (SG20, SG25, SG30) and stiff-rigged net (SRN34, SRN42, SRN50) on size selectivity. Methods A covered codend technique was used for determining the size selectivity of codends. Key results The average length at 50% retention probability (L50, in total length) for the trial groups of Com34, Hex34, SG20, SG25, SG30, SRN34, SRN42 and SRN50 was estimated as 9.1, 9.5, 10.1, 11.0, 12.3, 10.0, 10.3 and 11.1 cm respectively. Additionally, the discard rates were computed in the same order as 37.0, 27.3, 14.9, 5.8, 1.9, 19.1, 9.4 and 7.7%. Conclusions In conclusion, commercial crayfish (Com34) fyke-nets have a significantly high discard rate. In the modifications tested, the discard rate has been reduced to as low as 1.9%. When taking into account both L50 and fishing efficiency indicators, SRN42 was determined as the most successful trial group. Implications The application of the study results will make a significant contribution to the sustainability of natural crayfish stocks of Türkiye.
Diel patterns of habitat use and movement by juvenile and subadult trout cod (Maccullochella macquariensis) in a regulated lowland river
Authors: Koster Wayne M. , Dawson David R. , Moloney Paul D. 
Published: April 2024

Improved knowledge of habitat use and movements is needed to support recovery of threatened riverine fish species. The trout cod (Maccullochella macquariensis) is a nationally threatened fish species endemic to rivers of the southern Murray–Darling Basin (MDB), Australia. This study investigated diurnal and nocturnal habitat use and movements of trout cod in the Goulburn River, using radio-telemetry. Trout cod typically occupied small reaches (<300 m) of stream during the late spring–summer study period. Larger-scale movements (mostly home-range shifts) and movements onto inundated riparian habitats also occurred during a period of high discharge. Trout cod occupied deeper water further from the bank during the day and shallower water closer to the bank during the night and used areas with slower velocities more than was their availability, particularly during the earlier hours of the day. They also made extensive use of in-stream cover (i.e. wood). Our information on diel habitat use provides a platform to guide informed management (e.g. availability of preferred habitats under different river-discharge scenarios) to improve trout cod population sustainability.
Evaluation of transformation invariant loss function with distance equilibrium in prediction of imaging photoplethysmography characteristics
Authors: Zhu Shangwei , Liu Shaohua , Jing Xingjian , Li Bing , Liu Hao , Yang Yuchong , She Chundong 
Published: April 2024

Abstract

Objective. Monitoring changes in human heart rate variability (HRV) holds significant importance for protecting life and health. Studies have shown that Imaging Photoplethysmography (IPPG) based on ordinary color cameras can detect the color change of the skin pixel caused by cardiopulmonary system. Most researchers employed deep learning IPPG algorithms to extract the blood volume pulse (BVP) signal, analyzing it predominantly through the heart rate (HR). However, this approach often overlooks the inherent intricate time-frequency domain characteristics in the BVP signal, which cannot be comprehensively deduced solely from HR. The analysis of HRV metrics through the BVP signal is imperative. Approach. In this paper, the transformation invariant loss function with distance equilibrium (TIDLE) loss function is applied to IPPG for the first time, and the details of BVP signal can be recovered better. In detail, TIDLE is tested in four commonly used IPPG deep learning models, which are DeepPhys, EfficientPhys, Physnet and TS_CAN, and compared with other three loss functions, which are mean absolute error (MAE), mean square error (MSE), Neg Pearson Coefficient correlation (NPCC). Main results. The experiments demonstrate that MAE and MSE exhibit suboptimal performance in predicting LF/HF across the four models, achieving the Statistic of Mean Absolute Error (MAES) of 25.94% and 34.05%, respectively. In contrast, NPCC and TIDLE yielded more favorable results at 13.51% and 11.35%, respectively. Taking into consideration the morphological characteristics of the BVP signal, on the two optimal models for predicting HRV metrics, namely DeepPhys and TS_CAN, the Pearson coefficients for the BVP signals predicted by TIDLE in comparison to the gold-standard BVP signals achieved values of 0.627 and 0.605, respectively. In contrast, the results based on NPCC were notably lower, at only 0.545 and 0.533, respectively. Significance. This paper contributes significantly to the effective restoration of the morphology and frequency domain characteristics of the BVP signal.
Percolation in interdependent networks with groups and heterogeneous weak interdependency strength under targeted attack
Authors: Zhang Junjie , Liu Caixia , Liu Shuxin , Wang Kai , Zang Weifei 
Published: April 2024

Abstract
Pairwise dependencies in interdependent networks exist not only between ordinary nodes but also between groups of nodes, where nodes cooperate and form groups to increase their robustness to risks and each group can be considered a ‘supernode’. The interdependencies between supernodes are universal but not always complete and homogeneous. In this paper, we study the robustness of interdependent networks with groups and heterogeneous weak interdependency strength under targeted attack, where the interdependency strength could vary between different supernodes. We identify several types of percolation transitions, namely discontinuous, continuous, and hybrid, which are determined by the structure of the supernodes, the strengths of the interdependencies, and their distributions. We first apply this mathematical framework to the Erdös-Rényi and Scale-free interdependent networks with groups and homogeneous weak interdependency strength to calculate analytically and numerically the values of the phase transition thresholds and the critical interdependency strengths that distinguish different types of transitions. We then present examples of three distributions with different heterogeneous interdependency strengths. Our theoretical and numerical predictions are in close agreement, demonstrating that weaker interdependence strengths and higher levels of interdependence heterogeneity can enhance the robustness of interdependent networks under targeted attack.
Multiple Fano resonances by MIM waveguide coupling whispering gallery mode resonator and application in Refractive index sensing
Authors: Gao Jiayao , Wang Xiangxian , Chen Yizhen , Chen Tianshan , Qi Yunping , Yang Hua , Zheng Xiaoping 
Published: April 2024

Abstract
In this study, a baffled metal–insulator–metal (MIM) waveguide coupled with a whispering gallery mode resonator (WGMR) is proposed. This structure could excite quadruple Fano resonances. The asymmetric Fano resonance transmittance spectrum and the electric field at the resonance peak were numerically simulated using the finite difference time domain method. The obtained data were fitted using the multimode interference coupled mode theory. The number of Fano resonance peaks was tuned by the outer radius of the WGMR. With other geometric parameters unchanged, the number of Fano resonance peaks increased with increasing outer radius of the WGMR. Thus, it achieved multiple Fano resonances by adjusting solely the radius of the WGMR. When the ring width was fixed, the structure could excite multiple Fano resonances within a certain outer radius range. This structure was used for refractive index sensing and its sensitivity and figure of merit (FOM) were 3004 nm/RIU and 3.14 × 104 in a gas environment, respectively. Therefore, the proposed structure can excite multiple Fano resonances and achieve high sensitivity and FOM, providing a theoretical basis for micro and nano applications.
Masses of the conjectured H-dibaryon at different temperatures*
Authors: Wu 吴 Liang-Kai 良凯 , Tang 汤 Han 涵 , Li 李 Ning 宁 , Wang 王 Xin-Yang 昕杨 
Published: April 2024

Abstract
We present a lattice QCD determination of masses of the conjectured H-dibaryon, denoted as

, at nine different temperatures:

0.24, 0.63, 0.76, 0.84, 0.95, 1.09, 1.27, 1.52, and 1.90. The masses of baryons N, Σ, Ξ, and Λ at different temperatures were also computed. The simulations were performed on an anisotropic lattice with

flavours of clover fermion at a quark mass corresponding to

. The thermal ensembles were provided by the FASTSUM collaboration, whereas the zero temperature ensembles were provided by the Hadspec collaboration. We also calculated the spectral density of the correlation function of those particles. The spectral density distributions show a rich peak structure at the lowest temperature; at intermediate temperatures, the mass values of those particles obtained by the extrapolation method reflect a two-peak structure. While the spectral density for the octet baryon becomes smooth at

1.27, 1.52, and 1.90, the spectral density for the H-dibaryon becomes smooth at

. At

, the mass difference of the H-dibaryon and Λ pair, expressed as

, was estimated to be

MeV, which suggests the existence of a bound H-dibaryon state.
Study of 26 Galactic Open Clusters with Extended Main-sequence Turnoffs
Authors: Deng Yang-Yang , Li Zhong-Mu 
Published: April 2024

Abstract
Recent studies indicate that some Galactic open clusters (OCs) exhibit extended main-sequence turnoff (eMSTO) in their color–magnitude diagrams (CMDs). However, the number of Galactic OCs with eMSTO structures detected so far is limited, and the reasons for their formation are still unclear. This work identifies 26 Galactic OCs with undiscovered eMSTOs and investigates the causes of these features. Stellar population types and fundamental parameters of cluster samples are acquired using CMD fitting methods. Among them, the results of 11 OCs are reliable as the observed CMDs are well-reproduced. We propose the crucial role of stellar binarity and confirm the importance of stellar rotation in reproducing eMSTO morphologies. The results also show that the impact of age spread is important, as it can adequately explain the structure of young OCs and fit the observed CMDs of intermediate-age OCs better.
Teaching a hands-on session on simultaneous Positron Emission Tomography and Magnetic Resonance image acquisition and quantification in a clinical setting
Authors: Torrado-Carvajal A. , García-Cañamaque L. , Malpica N. 
Published: April 2024

Abstract
Positron Emission Tomography/Magnetic Resonance (PET/MR) imaging, is a novel imaging modality that combines the capabilities of two powerful imaging techniques in a single acquisition. This unique integration allows for simultaneous acquisition of both metabolic and structural data within a single imaging session. In this sense, PET/MR offers a comprehensive and innovative approach to medical imaging, but accompanied by its intrinsic physics and engineering complexity, involving intricate synchronization of high-performance detectors, electromagnetic shielding, and sophisticated correction algorithms, among others. In this hands-on session performed during the 6th INFIERI summer school (Madrid, Spain), we described an introduction to simultaneous PET/MR image acquisition and quantification in a real clinical to students from diverse backgrounds in physics and engineering. We first presented the fundamental aspects of PET/MR image acquisition, including the main theoretical characteristics of PET/MR physics and electronics, visiting the PET/MR facilities at Hospital Universitario HM Puerta del Sur (HM Hospitales, Móstoles, Madrid), and discussing the main PET/MR clinical and research applications. Then, we followed with a practical session on PET/MR image quantification, preparing the students to understand and solve examples on image reconstruction, multimodal data visualization, inhomogeneity correction, image registration, and attenuation correction exploiting the simplicity and usefulness of 3D Slicer.
A Micromegas-based gaseous detector for neutron-induced charged-particle reaction studies in nuclear astrophysics
Authors: Yadav C. , Green A. , Friedman M. 
Published: April 2024

Abstract
The quasistellar neutron spectrum produced via 7Li
(p, n)7Be reaction at a proton energy of 1.912 MeV has been
extensively studied and employed reaction for neutron-induced
reaction studies. We are working towards using this reaction at
various proton energies from 1.9 MeV to 3.6 MeV to produce a
neutron field at a temperature range of ∼ 1.5–3.5 GK to
conduct measurements of neutron-induced charge particle reaction
cross sections on various unstable nuclei at explosive stellar
temperatures. In this paper, we are reporting our design and
simulation study with regards to experimental set-up and a gaseous
detector with a segmented Micromegas detector for conducting
neutron-induced charge particle reactions studies for nuclei of
astrophysics importance, for example, 26Al(p, n)26Mg,
26Al(n, α)23Na and 40K(p, n)40Ar,
40K(n, α)37Cl reactions. We plan to perform our
experiments with a 10-μA proton beam at the Physikalisch
Technische Bundesanstalt facility (PTB, Germany), with a
Micromegas-based gaseous detector under construction as discussed in
the paper.