bluuebunny/crossref_metadata_2025_split huggingface dataset:
Carcinomas of the lacrimal drainage system
Authors: Callender David L. , Frankenthaler Robert A. , Weber Randal S. , Dodd Leslie , Batsakis John G. 
Published: February 2007

AbstractPrimary carcinomas of the lacrimal drainage system are rare. These malignant neoplasms typically present as noncompressible, nontender masses with low‐grade dacyrocystitis and/or unilateral epiphora. Lymph node metastasis may occur late in the disease course. Complete surgical resection is the best treatment choice; extensive procedures such as orbital exenteration and maxillectomy may be necessary for complete tumor extirpation. Further adjunctive radiotherapy may improve local control. We present two cases of carcinoma of the lacrimal drainage system, including one locally controlled tumor with apparent lymph node metastasis that occurred 21 years after primary treatment. A review of the histopathology and literature concerning carcinomas of the lacrimal drainage system is presented.
Hürthle cell adenoma arising in a thyroglossal duct cyst
Authors: Lyos Andrew T. , Schwartz Mary R. , Malpica Anais , Johnson Paul E. 
Published: February 2007

AbstractAn 18‐year‐old black woman was initially seen with a 1‐year history of a slowly enlarging midline neck mass. On physical examination this was consistent with a thyroglossal duct cyst. Histologic examination following a Sistrunk procedure revealed a Hürthle cell adenoma arising in a thyroglossal duct cyst. This is the second reported case of a Hürthle cell adenoma arising in a thyroglossal duct cyst. Neoplasms of thyroglossal duct cysts are reviewed.
Surgical management of chronic parotitis
Authors: O'Brien Christopher J. , Murrant Nicholas J. 
Published: February 2007

AbstractA series of 17 consecutive parotidectomies for chronic sialoadenitis is presented. This comprises 10% of all parotidectomies performed by one surgeon over the 5‐year period between 1987 and 1991. In 16 patients, symptoms were relieved by surgery. The extent of surgery was guided by the clinical findings. In this series, near total and superficial parotidectomy were equally efficacious and no patient suffered permanent facial nerve dysfunction. Surgery is a safe and effective treatment for parotitis.
Pilot trial of ribavirin for the treatment of laryngeal papillomatosis
Authors: McGlennen Ronald C. , Adams George L. , Lewis Cynthia M. , Faras Anthony J. , Ostrow Ronald S. 
Published: February 2007

AbstractThe antiviral drug ribavirin was used as an adjunct to laser surgery for the treatment of patients with laryngeal papillomatosis (LP). An uncontrolled clinical trial for four patients with ribavirin treatment at a daily dose of 23 mg/kg was performed. Three adults received drug prior to laser surgery and continuing orally for 6 months. One infant was treated for 3 months. Two adults achieved complete remissions for at least 2 consecutive months, and both patients developed only minimal recurrent disease in 4 months of follow‐up. The other adult and the child sustained a partial response and an increased interval between the required surgeries. Ribavirin caused only a mild, reversible reduction in hemoglobin and reticulocytosis. This preliminary trial shows that ribavirin may be an effective therapy in combination with surgery for LP in a larger controlled clinical trial.
Heterogeneity of salivary gland tumors studied by flow cytometry
Authors: Tytor Maciej , Gemryd Per , Wingren Sten , Grenko Ronald T. , Lundgren Jan , Lundquist Per‐G. , Nordenskjöld Bo 
Published: February 2007

AbstractIntratumor DNA heterogeneity was investigated by flow cytometric analysis of multiple samples taken from different sites of 8 benign and 16 malignant primarily resected salivary gland tumors. All benign tumors had diploid DNA content. The overall incidence of DNA diploidy in 16 malignant cases examined was 50%. Intratumor differences in DNA ploidy were observed in four malignant tumors (25%); 2 of these 4 heterogenous tumors contained both aneuploid and diploid cell clones. The remaining 12 tumors showed a homogeneous DNA content in the different specimens; 8 were diploid, 3 aneuploid, and 1 was polypoid. The DNA nondiploid tumors were clinically more advanced than the DNA diploid ones (p < 0.01). The tumor proliferation rate (fraction of cells in S‐phase) was higher in DNA nondiploid samples than in diploid ones (p < 0.01). The DNA nondiploid tumors seemed to recur more often than DNA diploid ones did. The data emphasize the usefulness of DNA measurements for the characterization of malignant salivary gland tumors but also the importance of adequate sampling in assessing their DNA ploidy.
Bacteriologic profile of surgical infection after antibiotic prophylaxis
Authors: Clayman Gary L. , Raad Issam I. , Hankins Patti D. , Weber Randal S. 
Published: February 2007

AbstractWound infections resulting from contamination during major head and neck surgery continue to be a critical issue. In this study, specimens of pus or draining fluids from the wounds of 43 surgical patients who received perioperative administration of ampicillin/sulbactam or clindamycin were cultured for aerobic and anaerobic isolates to the species level. Polymicrobial infections were identified in 13 of 43 patients (30%); 82% of isolates were aerobic organisms (45 of 55), and 18% were anaerobic or facultative species (10 of 55). Nine of 43 patients (21%) showed no bacterial isolates from cultured material. Independent of the primary site of malignancy or antibiotics used, nine of 25 isolates (36%) obtained from patients who underwent concomitant dental extractions, but only one of 24 (4%) who did not, developed anaerobic infections, (p < 0.001). The minimum inhibitory concentration of anaerobic isolates suggested sensitivity to the antibiotics used, and minimum bactericidal concentration data suggested that further postoperative doses may be required to adequately treat the heavily contaminated wounds. These data suggest that wound colonization following dental extraction procedures in clean contaminated head and neck surgery increases the risk of anaerobic infections. The use of a therapeutic dose and longer duration of perioperative antibiotics may be warranted.
Papillary thyroid cancer in Mexico: Review of 409 cases
Authors: Rodriguez‐Cuevas Sergio , Almendaro Sonia Labastida , Cardoso Juan M. Reyes , Maya Eduardo Rodriguez 
Published: February 2007

AbstractThis is a retrospective review of 409 cases of papillary thyroid cancer treated at the Hospital of Oncologia, National Medical Center, IMSS in Mexico City. The clinical features, histopathologic findings, analysis of recurrences and survivals according to age, sex, tumor size, and modality of treatment are described. The results showed that tumoral diameter > 5 cm, distant metastasis at diagnosis, age > 40 years, and tumoral infiltration beyond the thyroid capsule significantly affect the patient's survival.
Spontaneous infarction of parathyroid adenoma: Case report and literature review
Authors: Mir Rabia , Gerold Thomas , Khan Saad , Weitz Jean 
Published: February 2007

AbstractA patient with asymptomatic primary hyperparathyroidism who spontaneously became normocalcemia is reported. The only significant finding was that of pain and tenderness in the enlarged parathyroid gland 2 weeks prior to surgery. This was due to a recent infarction of a parathyroid adenoma.
Analysis of frequency of pulmonary atelectasis in patients undergoing pectoralis major musculocutaneous flap reconstruction
Authors: Schuller David E. , Daniels Robert L. , King Mark , Houser Steve 
Published: February 2007

AbstractThe incidence of pulmonary atelectasis following head and neck surgery is not well reported. This study retrospectively evaluated the incidence of pulmonary atelectasis in 161 head and neck cancer patients, with 152 being evaluable. There were 90 patients evaluated following pectoralis musculocutaneous flap reconstruction with their effective flap size and 71 nonflap patients as a control group. Clinical findings were correlated to radiographic scores. Of pectoralis musculocutaneous flap patients screened for preexisting pulmonary disease (PEPD), nine of 45 (20%) demonstrated pulmonary atelectasis in the first 24 hours compared with 10 of 39 or 25.6% nonflap controls. Major pulmonary atelectasis was not found in the pectoralis musculocutaneous flap patients by scoring criteria, and in only one of 39 (2.6%) nonflap patients. In flaps larger than 40 cm2, the incidence was eight of 37 (21.6%), with no major pulmonary atelectasis noted. Only one of nine (11.1%) patients with radiographic pulmonary atelectasis exhibited clinical symptoms (three of 10 or 30% control). In patients with PEPD and pectoralis musculocutaneous flaps, 22 of 45 (48.9%) had evidence of pulmonary atelectasis in contrast to 13 of 32 or 40.6% controls. There were two of 45 (4.4%) who had major pulmonary atelectasis with zero of 32 in the nonflap group. For flaps larger than 40 cm2, the incidence was 19 of 39 (48.7%) with two of 39 (5.1%) scored as major pulmonary atelectasis. The clinical correlation for this group and the major pulmonary atelectasis group was each approximately 50% compared to 15.4% for nonflap patients. These results indicate that, although the incidence of radiographic pulmonary atelectasis in the first 24‐hour postoperative period is high, there is no clinical correlation with the exception of patients with PEPD. © 1994 John Wiley & Sons, Inc.
Axillary metastases from carcinoma of the larynx: A 25‐year survival
Authors: Nelson William R. , Sisk Michael 
Published: February 2007

AbstractAxillary metastases from squamous cell carcinomas of the head and neck are usually considered signs of incurability. A case is presented in which the patient developed well‐differentiated squamous cell carcinoma in bilateral axillary nodes following total laryngectomy and radical neck dissection for advanced recurrent squamous cell carcinoma of the larynx. Bilateral axillary dissection was performed on this patient followed by a second neck dissection for metastasis. The patient remained well for 25 years free of disease, dying of a massive heart attack. One report of this phenomenon has been found in the literature. The authors conclude that radical axillary dissection should be considered in selective cases of well‐differentiated carcinoma in axillary nodes from a controlled primary in the head and neck mucosa when no other signs of dissemination have been found. A brief review of cervical and axillary lymphatic anatomy is included. © 1994 John Wiley & Sons, Inc.
Soft tissue coverage of mandibular reconstruction plates
Authors: Cordeiro Peter G. , Hidalgo David A. 
Published: February 2007

AbstractFree tissue transfer was compared to pectoralis major flap coverage of mandibular reconstruction plates in a retrospective review. The study group consisted of 14 patients whose composite defects were reconstructed with metal plates covered with either pectoralis flaps (9) or soft tissue free flaps (5). Four patients in the pectoralis group (44%) had plates that extruded compared to none in the free flap group. The mean operating room time for the free flap group (721 minutes) was longer than the pectoralis group (550 minutes), but the overall hospital stay for the free flap group (20 days) was half that of the pectoralis group (39 days). The pectoralis group required more secondary procedures (88%) than the free flap group (20%). Free flaps have a higher success rate, a shorter hospital stay, and require fewer additional procedures than do pectoralis flaps. This justifies the longer operating time and greater technical complexity of free tissue transfer for reliable coverage of mandibular reconstruction plates. © 1994 John Wiley & Sons, Inc.
Permanent iodine‐125 implants in postoperative radiotherapy for head and neck cancer with positive surgical margins
Authors: Vikram Bhadrasain , Mishra Shantilata 
Published: February 2007

AbstractBackground.Patients with head and neck cancer treated surgically have a high local recurrence rate, unless the surgeon is able to obtain adequate margins of resection. In patients with positive margins, tumor control is suboptimal despite postoperative radiotherapy.Methods.We treated 25 consecutive patients, who were at high risk for local recurrence by virtue of positive margins, by modest dose postoperative external‐beam irradiation (median 60 Gy) followed by elective iodine 125 (I‐125) implantation.Results.With a median follow‐up of 1.5 years (range 1‐5 years), there were no instances of necrosis, and only one (4%) instance of a local recurrence. Six patients (24%) developed distant metastases.Conclusions.These results indicate that elective 1‐125 implantation as a part of postoperative radiotherapy is safe enough for a phase III study in patients with positive margins. © 1994 John Wiley & Sons, Inc.
Thymidylate synthase activity, folates, and glutathione system in head and neck carcinoma and adjacent tissues
Authors: Parise Orlando , Janot François , Luboinski Bernard , Massaad Liliane , Albin Nicolas , Toussaint Caroline , Verjus Marie‐Ange , Bonnay Marc , Gouyette Alain , Chabot Guy G. 
Published: February 2007

AbstractBackground. Head and neck squamous cell carcinomas (HNSCC) present variable aggressiveness and chemosensitivity. Because the glutathione (GSH) system and thymidylate synthase (TS) are involved in the resistance to the main drugs used in HNSCC (cisplatin and 5‐FU), we studied these systems in tumors and normal mucosae.Methods. Tumor samples and normal adjacent mucosae were collected from 37 untreated HNSCC patients. GSH and glutathione S‐transferase (GST) activity were assayed by spectrophotometry, whereas TS activity and folates were determined by radioassays.Results. Mean GSH levels were higher in tumors (15.2 ± 8.2 nmol/mg protein) than in mucosae (8.3 ± 4.1 nmol/mg protein) (p = 0.005, paired t test). GST activity was also higher in tumors (394 ± 194 nmol/min/mg protein) than in mucosae (261 ± 132 nmol/min/mg protein) (p = 0.0003). TS activity was markedly higher in tumors (9.2 ± 21.5 pmol/min/mg protein) compared to that of mucosae (0.9 ± 1.2 pmol/min/mg protein) (p = 0.0001). Folate levels in tumors and mucosae were similar (1.2 ± 1.1 and 0.8 ± 0.9 pmol/mg protein, respectively; p = 0.1, NS). In relation to clinical stage and tumor size, a statistical difference was found in GSH and GST values between tumors and mucosae for stage IV and T3/T4. The increase in tumor TS compared to that of mucosae was significant for all clinical stages, tumor sizes, and nodal involvement.Conclusions. These data enhance our understanding of the enzymatic systems involved in cisplatin and 5‐fluorouracil (5‐FU) resistance in HNSCC and normal mucosae and may help to elucidate tumor behavior and interpatient differences in drug sensitivity. © 1994 John Wiley & Sons, Inc.
Spinal accessory nerve palsy: An unusual complication of rhytidectomy
Authors: Blackwell Keith E. , Landman Michael D. , Calcaterra Thomas C. 
Published: February 2007

AbstractRhytidectomy is a safe and effective procedure for rejuvenation of the aging face. Reported complication rates vary between 2.5% and 28%, and with proper management, longterm sequelae are unusual. Injury to the spinal accessory nerve is a rare but potentially debilitating complication of rhytidectomy. Afflicted patients present with dull, constant pain in the shoulder region which can be severe in nature. In addition, there is weakness of shoulder abduction and cosmetic deformity related to trapezius atrophy. Measures for conservative management include analgesics and physical therapy to strengthen the shoulder girdle. Nerve exploration is indicated for cases with documented denervation that do not respond to conservative treatment. A review of the English literature identified two previous case reports of spinal accessory nerve injury sustained during rhytidectomy. In this report, we present two additional cases and review current concepts regarding diagnosis, management, and prevention of this unusual complication of rhytidectomy. © 1994 John Wiley & Sons, Inc.
Intracavernous carotid pseudoaneurysm after blunt trauma: Case report and discussion
Authors: Reiber Mark E. , Burkey Brian B. 
Published: February 2007

AbstractEpistaxis following blunt facial trauma is usually self‐limited and arises from the nasal mucosa, sphenopalatine, or anterior ethmoid arteries. Pseudoaneurysm of the intracavernous carotid artery (ICCA) occurs rarely with penetrating facial trauma, but is even more rare following blunt trauma. Rupture carries a greater than 50% mortality. Because rupture usually occurs after several episodes of epistaxis, recognition of subtle historic and physical findings is paramount to optimal management. Once suspicion is raised, definitive diagnosis and treatment is best accomplished with cerebral arteriogram and trapping of the pseudoaneurysm. We have noted that rupture may be precipitated by angiography, and, therefore, we advocate availability of emergent and definitive treatment equipment and personnel prior to performing cerebral arteriography. This should include an otolaryngologist, an interventional radiologist, and a neurosurgeon. A case of ICCA pseudoaneurysm is presented, and the key historic factors are discussed. Radiographic diagnosis and management options are discussed. © 1994 John Wiley & Sons, Inc.
Cervical and mediastinal emphysema secondary to third molar extraction
Authors: Goodnight James W. , Sercarz Joel A. , Wang Marilene B. 
Published: February 2007

AbstractBackground. A dramatic case of infected emphysema involving multiple deep cervical and mediastinal fascial planes following surgical extraction of a lower third molar in an otherwise healthy man is presented.Methods. The differential diagnosis and management of this condition are discussed, specifically contrasting it to necrotizing fasciitis.Results. The direct cause of this complication was the use of an air turbine handpiece and air syringe for the tooth extraction.Conclusions. It is advised that air turbine handpieces and air syringes not be used during minor oral surgical procedures. © 1994 John Wiley & Sons, Inc.
Complications of craniofacial resection for tumors involving the anterior skull base
Authors: Kraus Dennis H. , Shah Jatin P. , Arbit Ehud , Galicich Joseph H. , Strong Elliot W. 
Published: February 2007

AbstractBackground.A consecutive series of 85 patients undergoing craniofacial resection for malignant tumors involving the anterior cranial base between 1974 and 1992 was reviewed.Results.There were two (2%) postoperative deaths. Postoperative complications occurred in 33 (39%) patients. Local major complications occurred in 26 (31%) patients, local minor in 7 (8%), and systemic in 5 (6%). More than one complication occurred in a number of patients. Bacterial contamination led to a significant proportion of local, septic complications. Repair of the skull base defect with a pedicled pericranial flap was unsatisfactory and was associated with an increased incidence of local major complications. A local major complication was associated with a dramatic lengthening of hospitalization.Conclusion.Future endeavors for prevention of complications should focus on antibiotic prophylaxis and reconstruction of the cranial base defect with better vascularized flaps. © 1994 John Wiley & Sons, Inc.
Pilot study of positron emission tomography in patients with advanced head and neck cancer receiving radiotherapy and chemotherapy
Authors: Berlangieri Salvatore U. , Brizel David M. , Scher Richard L. , Schifter Tobias , Hawk Thomas C. , Hamblen Sharon , Coleman R. Edward , Hoffman John M. 
Published: February 2007

AbstractBackground. Positron emission tomography (PET) provides a noninvasive modality for evaluating the biochemical processes of normal and pathologic tissue. Preliminary reports of F‐18 fluorodeoxyglucose (FDG) PET indicate its potential usefulness in evaluating head and neck tumors. The current study was performed to explore the relationship between changes in tumor FDG metabolism and local control in patients receiving hyperfractionated radiotherapy and concurrent chemotherapy.Methods. The study group consisted of six patients with locally advanced, nonmetastatic squamous cell carcinoma of the head and neck. FDG studies were performed prior to, during, and 24 months post‐therapy. Ratios of tumor to nontumor FDG uptake in regions of interest (ROI) were compared.Results. All pretherapy studies demonstrated a focal hypermetabolic abnormality corresponding to the known tumor. The pretherapy tumor to nontumor FDG ratios declined significantly during therapy (p < 0.05) with a similar continued trend post‐therapy (p < 0.07).Conclusion. The treatment‐induced decrease in tumor hypermetabolism as seen on serial FDG PET parallels the clinical response in squamous carcinoma of the head and neck. Two‐year follow‐up scans also suggest that continued low tumor to nontumor ratios reflect eradication of local disease. Because of its high cost, a study of larger numbers of patients is necessary to better define the role of PET in the management of head and neck cancer. © 1994 John Wiley & Sons, Inc.
Intracranial extension of a nasal dermoid sinus cyst in A 56‐year‐old man
Authors: Hacker David C. , Freeman Jeremy L. 
Published: February 2007

AbstractBackground. Nasal dermoid sinus cysts are rare congenital lesions that result from aberrant embryonal development. Cases of nasal dermoids associated with intracranial extension have been reported in the past, but have almost always occurred in children.Methods. One case of a nasal dermoid cyst with intracranial involvement in a 56‐year‐old man is reported herein.Results. A 56‐year‐old man presented with a draining sinus in the right medial canthal area and a nasal pit. Imaging studies suggested a nasal dermoid cyst with intracranial extension. He subsequently underwent a craniofacial removal of the lesion with a satisfactory postoperative course.Conclusion. That nasal dermoid cysts can remain dormant until the age of 56 suggests that the incidence of this lesion with intracranial extension may be higher than previously reported. A one‐stage combined otolaryngologic/ neurosurgical procedure is advocated for those lesions that are extra‐ and intracranial. © 1994 John Wiley & Sons, Inc.
Carcinosarcoma (malignant mixed tumor) of the parotid: Report of a case with a pure rhabdomyosarcoma component
Authors: Gandour‐Edwards Regina F. , Donald Paul J. , Vogt Philip J. , Munn Robert , Min Kyung‐Whan 
Published: February 2007

AbstractBackground. Carcinosarcoma or true malignant mixed tumor of the parotid gland is extremely rare, accounting for <1% of all salivary gland malignancies.Methods. A 63‐year‐old woman presented with a 5‐cm right parotid mass which was resected with a radical parotidectomy and infratemporal fossa dissection.Results. The tumor contained two distinctive histologic patterns, that of a poorly differentiated ductal carcinoma and a pleomorphic rhabdomyosarcoma. Additionally, a residual focus of pleomorphic adenoma was present peripherally, Immunohistochemical and electron microscopic studies confirmed the skeletal muscle differentiation.Conclusions. The pattern of combined rhabdomyosarcoma and ductal carcinoma has not been previously reported and adds further evidence to the myoepithelial derivation of these tumors. © 1994 John Wiley & Sons, Inc.