bluuebunny/crossref_metadata_2025_split huggingface dataset:
To move or to be promoted: Examining the effect of promotions and academic mobility on professors' productivity and impact
Authors: Wu Chaojiang , Yan Erjia , Ni Chaoqun , He Jiangen 
Published: April 2024

AbstractPromotions and academic mobility are trajectory‐altering events in a researcher's career. This paper compiles a unique large data set and investigates publication and citation differences between two groups of researchers: the ones who are mobile and their counterparts who stay at a university with a promotion. This paper finds that mobile researchers often have a lesser productivity increase than their post‐promotion counterparts. The difference is largely driven by male professors in physical science and clinical health fields moving from more research‐intensive to less research‐intensive institutions. In contrast, the citational impact differences between the two groups are largely minimal.
Na/N Co‐doped Seaweed Biochar Composite for Efficient Removal of Aqueous Pb(II) and Cu(II)
Authors: Fu Meiyuan , Ma Qianhui , Luo Yun , Feng Wen , Wang Xianghui 
Published: April 2024

AbstractPollution from harmful heavy metal ions such as Pb(II) and Cu(II) is causing serious environmental and health problems. In this study, Sodium and nitrogen co‐doped porous carbon material (Na/NABc) was successfully prepared from seaweed, sodium hydroxide, and dicyandiamide. The experimental results showed that Na/NABc is an excellent adsorbent for the effective removal of Pb(II) and Cu(II) from water bodies. Specifically, 99.8% of Pb(II) and 64.6% Cu(II) (100 mg/L) were removed within 12 h using 10 mg Na/NABc(10%) at 25 °C. The adsorption of Pb(II) and Cu(II) in aqueous solution by Na/NABc(10%) was efficient and rapid in the first stage. The theoretical maximum removal capacities of Na/NABc for Pb(II) and Cu(II) were 959.6 and 299.1 mg/g, respectively. Pb(II) and Cu(II) ions were adsorbed quickly in the first 60 min, and the kinetics data were generally consistent with a pseudo‐second‐order model. Na/NABc(10%) had a large distribution coefficient for Pb(II) (8.38 L/mg) and Cu(II) (1.17 L/mg). The possible mechanisms were precipitation, Ion exchange, and surface complexation. The removal rate can reach about 70% after five cycles, and the release of sodium meets the standard. The results of this study demonstrate the potential applicability of Na/NABc(10%) for adsorption of heavy metals from aqueous solution.
Homogeneous and Heterogeneous Frustrated Lewis Pairs for the Activation and Transformation of CO2
Authors: Du Tao , Zhang Peng , Jiao Zhen , Zhou Jiancheng , Ding Yuxiao 
Published: April 2024

AbstractDue to the serious ecological problems caused by the high CO2 content in the atmosphere, reducing atmospheric CO2 has attracted widespread attention from academia and governments. Among the many ways to mitigate CO2 concentration, the capture and comprehensive utilization of CO2 through chemical methods have obvious advantages, whose key is to develop suitable adsorbents and catalysts. Frustrated Lewis pairs (FLPs) are known to bind CO2 through the interaction between unquenched Lewis acid sites/Lewis base sites with the O/C of CO2, simultaneously achieving CO2 capture and activation, which render FLP better potential for CO2 utilization. However, how to construct efficient FLP targeted for CO2 utilization and the mechanism of CO2 activation have not been systematically reported. This review firstly provides a comprehensive summary of the recent advances in the field of CO2 capture, activation, and transformation with the help of FLP, including the construction of homogeneous and heterogeneous FLPs, their interaction with CO2, reaction activity, and mechanism study. We also illustrated the challenges and opportunities faced in this field to shed light on the prospective research.
Quantifying the influence of the Madden–Julian oscillation on rainfall extremes during the northeast monsoon season of the Philippines
Authors: Olaguera Lyndon Mark P. , Manalo John A. , Bathan Alwin , Matsumoto Jun 
Published: April 2024

AbstractThis study investigates the impact of the Madden–Julian Oscillation (MJO) on the extreme rainfall events across 11 eastern coastal stations during the northeast monsoon season (November to March) over the Philippines from 1979 to 2019. The contribution of synoptic systems to these extreme rainfall events such as tropical cyclones (TCs), low‐pressure systems (LPS), cold surges (CS), and other disturbances as they coincide with a strong and active MJO were quantified. The results show that the probability of extreme rainfall occurrence increases first to as much as 20% in the southernmost stations in Phase 4. Then, it increases to more than 60% in central‐eastern stations in Phase 6. The extreme rainfall events were then classified into: MJO‐only, TC‐MJO, TC‐nonMJO, LPS‐MJO, LPS‐nonMJO, CS‐MJO, CS‐nonMJO, and others. The percentage contribution of MJO only, TC‐MJO, LPS‐MJO, and CS‐MJO to the total extreme rainfall events ranges from 9% to 16%, 0% to 3%, 2% to 4%, 1% to 9%, respectively. The relationship between MJO and flooding events in the Philippines was also examined. About 28 flood events or 266 flooding days were identified during the analysis period, wherein 50% of these events coincidentally occurred during strong and active phases of MJO.
The effects of hyaluronan and proteoglycan link protein 1 (HAPLN1) in ameliorating spinal cord injury mediated by Nrf2
Authors: Yang Hongzhi , Hu Bin , Wang Xichun , Chen Wenjie , Zhou Huanbin 
Published: April 2024

AbstractExcessive inflammatory response and oxidative stress (OS) play an important role in the pathogenesis of spinal cord injury (SCI). Balance of inflammation and prevention of OS have been considered an effective strategy for the treatment of SCI. Hyaluronan and proteoglycan link protein 1 (HAPLN1), also known as cartilage link protein, has displayed a wide range of biological and physiological functions in different types of tissues and cells. However, whether HAPLN1 regulates inflammation and OS during SCI is unknown. Therefore, we aimed to examine whether HAPLN1 can have a protective effect on SCI. In this study, both in vitro and in vivo SCI models were established. Nissl staining and terminal deoxynucleotidyl transferase dUTP nick end labeling staining assays were used. Western blotting and enzyme‐linked immunosorbent assay were employed to assess the expression of proteins. Our results demonstrate that the administration of HAPLN1 promoted the recovery of motor neurons after SCI by increasing the Basso mouse scale score, increasing the numbers of motor neurons, and preventing apoptosis of spinal cord cells. Additionally, HAPLN1 mitigated OS in spinal cord tissue after SCI by increasing the content of superoxide dismutase SOD and the activity of glutathione peroxidase but reducing the levels of malondialdehyde. Importantly, we found that HAPLN1 stimulated the activation of the nuclear factor erythroid 2‐related factor 2 (Nrf2)/antioxidant response element (ARE) pathway and stimulated the expression of heme oxygenase‐1 and nicotinamide adenine dinucleotide phosphate quinone oxidoreductase‐1, which mediated the attenuation of HAPLN1 in activation of the NOD‐like receptor protein 3 (NLRP3) inflammasome by reducing the levels of NLRP3, apoptosis‐associated speck‐like protein containing a caspase recruitment domain (ASC), caspase‐1, and interleukin‐1β. Correspondingly, in vitro experiments show that the presence of HAPLN1 suppressed the NLRP3 inflammasome and prevented cell injury against H2O2 in PC12 cells. These effects were mediated by the Nrf2/ARE pathway, and inhibition of Nrf2 with ML385 abolished the beneficial effects of HAPLN1. Based on these findings, we conclude that HAPLN1 inhibits the NLRP3 inflammasome through the stimulation of the Nrf2/ARE pathway, thereby suppressing neuroinflammation, enhancing motor neuronal survival, and improving the recovery of nerve function after SCI.
Isoquinoline‐based intrinsic fluorescence assessment of erythropoiesis‐stimulating agent, Roxadustat (FG‐4592), in tablets: applications to content uniformity and human plasma evaluation
Authors: Batakoushy Hany A. , Hafez Hani M. , Soliman Marwa M. , Mohamed Tahany F. , Ahmed Amal B. , El Hamd Mohamed A. 
Published: April 2024

AbstractIn the present study, a first validated and green spectrofluorimetric approach for its assessment and evaluation in different matrices was investigated. After using an excitation wavelength of 345 nm, Roxadustat (ROX) demonstrates a highly native fluorescence at an emission of 410 nm. The influences of experimental factors such as pH, diluting solvents, and different organized media were tested, and the most appropriate solvent choice was ethanol. It was confirmed that there was a linear relationship between the concentration of ROX and the relative fluorescence intensity in the range 60.0–1000.0 ng ml−1,with the limit of detection and limit of quantitation, respectively, being 17.0 and 53.0 ng ml−1. The mean recoveries % [±standard deviation (SD),n = 5] for pharmaceutical preparations were 100.11% ± 2.24%, whereas for plasma samples, they were 100.08 ± 1.08% (±SD,n = 5). The results obtained after the application of four greenness criteria, Analytical Eco‐Scale metric, NEMI, GAPI, and AGREE metric, confirmed its eco‐friendliness. In addition, the whiteness meter (RGB12) confirmed its level of sustainability. The International Council for Harmonisation (ICH) criteria were used to verify the developed method through the study in both spiked plasma samples and content uniformity evaluation. An appropriate standard for various applications in industry and quality control laboratories was developed.
Climate risk and opportunity exposure and firm value: An international investigation
Authors: Li Xuefeng , Luo Le , Tang Qingliang 
Published: April 2024

AbstractWhile previous studies mainly focus on the valuation of greenhouse gas (GHG) emissions and climate risk exposure, climate opportunity exposure is less frequently visited in the current literature. We use an international sample from 23 countries that have participated in the CDP. By categorizing climate risks/opportunities into physical, regulatory and other, the study suggests that investors have an asymmetrical valuation for different categories of risks and opportunities. Specifically, investors value climate regulatory risk and other (market‐based) climate risks negatively, but not similarly for recognized climate opportunities. Finally, our findings confirm industry matters for investors' valuation decisions by altering their perceptions of the significance of climate risks and opportunities.
Forensic neuropsychological assessment
Authors: Marcopulos Bernice A. , Kaufmann Paul , Patel Anisha C. 
Published: April 2024

AbstractWith its firm establishment as a neuropsychology subspecialty, forensic neuropsychological assessment is integral to many criminal and civil forensic evaluations. In addition to evaluating cognitive deficits, forensic neuropsychologists can provide reliable information regarding symptom magnification, malingering, and other neurocognitive and psychological issues that may impact the outcome of a particular legal case. This article is an overview and introduction to neuropsychological assessment in the forensic mental health context. Major issues impacting the current practice of forensic neuropsychology are summarized, and several examples from case law are highlighted.
Outcomes after fertility‐sparing surgery of early‐stage ovarian cancer: A nationwide population‐based study
Authors: Lee Chia‐Yi , Chiang Chun‐Ju , Tai Yi‐Jou , Hsu Heng‐Cheng , Chen Yu‐Li , Chiang Ying‐Cheng , Wu Chia‐Ying , Lee Wen‐Chung , Hwa Hsiao‐Lin , Cheng Wen‐Fang 
Published: April 2024

AbstractBackgroundFertility‐sparing surgery (FSS) is an alternative choice of young patients who have not completed their family planning and still have fertility needs. The aims of this study were to compare the outcomes of early‐stage epithelial ovarian cancer (EOC) patients undergoing FSS and radical comprehensive staging surgery (RCS), and the suitability of FSS.MethodsA total of 1297 patients aged between 20 and 44 years with newly diagnosed early‐stage EOC were recruited from the Taiwan Cancer Registry database between 2009 and 2017. Site‐specific surgery codes were used to distinguish patients in FSS group or RCS group. Cancer‐specific survival (CSS) was evaluated using Kaplan–Meier method with log‐rank test and Cox regression model.ResultsThere were 401 and 896 patients in FSS and RCS group. Patients in FSS group were with younger age and mostly had Stage I disease. In contrast, patients in RCS group were older. There were more Stage II, high‐grade (Grade 3) disease, and adjuvant chemotherapy in RCS group. Stage and tumor grade were two independent factors correlating with CSS and the type of surgery showed no effect on CSS (HR: 1.09, 95% CI: 0.66–1.77, p = 0.73) in multivariable analysis. In multivariable analysis, the clear cell carcinoma group who underwent FSS demonstrated better CSS compared to those in the RCS group (HR: 0.28, 95% CI: 0.06–0.82, p = 0.04). A total of 17 women who underwent FSS developed second malignancies of the uterine corpus or contralateral ovary.ConclusionFSS can be a safe alternative procedure in selected young patients of Stage I EOC who have fertility desire. Endometrial biopsy before or during FSS and regular surveillance to detect recurrence are mandatory for ovarian cancer patients undergoing FSS.
Design, Synthesis, Docking Studies and Molecular Dynamics Simulation of New 1,3,5‐Triazine Derivatives as Anticancer Agents Selectively Targeting Pancreatic Adenocarcinoma (Capan‐1)
Authors: Asghar Shazia , Hameed Shahid , Al‐Masoudi Najim A , Saeed Bahjat , Shtaiwi Amneh 
Published: April 2024

AbstractOn the basis of remarkable anticancer profile of s‐triazine nucleus, a new series of 2‐methoxy‐4‐(3‐morpholino‐5‐(arylamino)phenoxy)benzaldehyde derivatives 11 a–u was prepared and evaluated for in vitro antiproliferative activity against eight diverse human cancer cell lines (Capan‐1, HCT‐116, LN229, NCI‐H460, DND‐41, HL‐60, K562 and Z138). Compounds 11 o, 11 r and 11 s were the most potent anticancer agents on pancreatic adenocarcinoma (Capan‐1) cell line with IC50 value of 1.4, 5.1 and 5.3 μM, respectively, while compounds 11 f, 11 g, 11 k, 11 l and 11 n displayed selective activity against the pancreatic adenocarcinoma (Capan‐1) cell line with IC50 values of 7.3–11.5 μM. These results indicate that derivative 11 o may serve as a promising lead compound for the ongoing development of novel antiproliferative agents. The docking studies were conducted to predict the interactions of derivative 11 o with putative protein targets in pancreatic adenocarcinoma (Capan‐1) cell line, specifically the prenyl‐binding protein PDEδ. Furthermore, the analysis of the molecular dynamics simulation results demonstrated that complex 11 o promoted a higher stability to the prenyl‐binding protein PDEδ.
Protective Effects of Tunisian Orange Co‐Product Extract and Oleuropein‐Hesperidin Combination on Bleomycin‐Induced Pulmonary Fibrosis in Rats
Authors: Mariem Ben Abdallah , Sana Bahri , Afef Nahdi , Mona Mlika , Linda Hadjkacem , Saloua Jameleddine , Nourhene Boudhrioua 
Published: April 2024

AbstractIdiopathic pulmonary fibrosis (IPF) is a chronic interstitial pneumonia that leads to acute lung damage, deterioration of lung function, and increased mortality risk. In this study, we investigated the effects of the orange coproduct extract (OCE) and the combination of pure hesperidin and oleuropein (HO) on an experimental model of pulmonary fibrosis induced by bleomycin (BLM) in Wistar rats. Rats were divided into six groups: the control group (G1), the BLM group (G2), three groups (G3, G4, G5) receiving a single dose of BLM combined with OCE extract at 100, 200, and 300 mg/kg, and group 6 (G6) receiving a single dose of BLM combined with HO: both pure major phenolic compounds of OCE (hesperidin at 50 mg/kg) and olive leaves (oleuropein at 2.5 mg/kg). Oxidative stress in lung tissues was investigated using catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPX) assays and the measurement of malondialdehyde (MDA) and lactate dehydrogenase (LDH) levels. Treatment with OCE and HO normalized the disturbance in oxidative markers′ levels and showed a significant reduction in fibrosis score with no renal or hepatic toxic effects. In conclusion, OCE and HO exhibit antifibrotic effects on a rat model of pulmonary fibrosis.
A novel method for enrichment of Morganella morganii in fecal samples using designed culture medium
Authors: Jalandra Rekha , Dalal Nishu , Mohan Anand , Solanki Pratima Rathi , Kumar Anil 
Published: April 2024

AbstractMorganella morganii is a gram negative, facultative anaerobic rod‐shaped bacterium, commonly found in environment and in the intestine of human, mammals, and reptiles as a part of their gut microbiome. M. morganii can cause Gram‐negative folliculitis, black nail infection, acute retiform purpura, fetal demise, and subdural empyema. The increasing frequency of M. morganii infections generate the need for efficient methods to enrich the presence of M. morganii in clinical samples to make its detection easier. Culturomics aims to grow and maximize the number of culturable bacteria. Different methods are followed to maximize the growth of minority population of bacteria by disrupting the growth of bacteria which are present in higher concentration. This article presents a method for selective enriching the M. morganii in human fecal samples. This method includes prior incubation of fecal microbiota in an anaerobic environment, adding supplement like fecal water to give dormant bacteria a break to become active to grow to threshold concentration, and an enrichment stage which provides the additional opportunity of growing to M. morganii on the selective medium. This method also provides an ingenuous way for augmenting the growth of fecal M. morganii species.
Microkinetic Model as a Crucial Tool for Understanding Homogeneous Catalysis
Authors: Rama Raquel J. , Nova Ainara , Nicasio M. Carmen 
Published: April 2024

AbstractMicrokinetic modeling is a computational tool that allows simulating the evolution of the concentration of catalytically relevant species with time, providing a description of the catalytic system closer to the experimental. Microkinetic models have been mainly applied in organometallic catalysis as a means for validating mechanistic proposals by comparing experimental and computed rates and concentrations at a given time. However, this tool becomes very useful when studying complicated reaction mechanisms, aiding in identifying the catalyst resting state, optimizing reaction conditions, or improving the catalyst design. In this Concept, we focus on these applications of microkinetic modeling through the discussion of some selected examples. In addition, we also point out some of the challenges and limitations we may face when building microkinetic models, which may explain why they are still underused.
Elucidating the Binding Mode of Sulfur‐ and Selenium‐Based Cationic Chalcogen‐Bond Donors
Authors: Akbaba Sercan , Steinke Tim , Vogel Lukas , Engelage Elric , Erdelyi Mate , Huber Stefan M. 
Published: April 2024

AbstractFor a comparison of the interaction modes of various chalcogen‐bond donors, 2‐chalcogeno‐imidazolium salts have been designed, synthesized, and studied by single crystal X‐ray diffraction, solution NMR and DFT as well as for their ability to act as activators in an SN1‐type substitution reaction. Their interaction modes in solution were elucidated based on NMR diffusion and chemical shift perturbation experiments, which were supported by DFT‐calculations. Our finding is that going from lighter to the heavier chalcogens, hydrogen bonding plays a less, while chalcogen bonding an increasingly important role for the coordination of anions. Anion‐π interactions also show importance, especially for the sulfur and selenium derivatives.
Unidentical Twins: Geometrically Similar but Chemically Distinct Metal‐Free Sites in Boron Oxide for Methane Oxidation to HCHO, CO and CO2
Authors: Rawal Parveen , Gupta Puneet 
Published: April 2024

AbstractMetal‐free boron‐based catalysts such as boron oxide (B2O3) and boron nitride (h‐BN) are promising catalysts for methane oxidation to HCHO and CO. The B2O3 catalyst contains various probable boron sites (B1 to B6), which may be responsible for methane oxidation. In this work, we utilized density functional theory to compare two relevant geometrically identical boron sites (B2 and B4) for their reactivities. The two sites are explored in‐detail for the conversion of methane to formaldehyde (M2F), carbon monoxide and carbon dioxide. The B4 site activates the methane C−H bond easily as compared to the B2 site. In M2F conversion, the rate‐determining step for the B2 site is the co‐activation of dioxygen and methane, whereas over the B4 site, formaldehyde formation is the rate‐determining step. The computationally‐determined RDS for the B4 site coincides well with the reported experiments. It is further revealed that this site also prefers the formation of CO over CO2, which is in‐line with the experiments in literature. It is also shown through orbital analysis that methanol formation does not occur during methane oxidation. We employed descriptors such as condensed Fukui functions and global electrophilicity index to chemically distinct these twin sites.
How to Measure the Greenness of Chemicals? A Case Study on Butadiene Production Applying Green Metrics and Life Cycle Assessment
Authors: Maga Daniel , Röttgen Janek , Blömer Jan , Wu Zhengxuan , Greuel Marc , Hiebel Markus , Zeidler‐Fandrich Barbara , Eilebrecht Sebastian 
Published: April 2024

AbstractThe greenness of naphtha‐ and bioethanol‐based butadiene was compared using green metrics (GM) and life cycle assessment (LCA). GM provide predominantly qualitative results, showing advantages for bioethanol‐based butadiene. LCA indicates benefits of bioethanol‐based butadiene in terms of global warming and fossil resource consumption, but drawbacks in acidification, eutrophication, radiation, land use, ozone depletion, particulate matter, ozone formation, metal depletion, and freshwater consumption. When comparing both assessment approaches used, LCA offers a more comprehensive environmental assessment while GM is limited to a smaller section of the value chain but address additional aspects such as safety of chemicals.