bluuebunny/crossref_metadata_2025_split huggingface dataset:
STK10 mutations block erythropoiesis in acquired pure red cell aplasia via impairing ribosome biogenesis
Authors: Yang Jichun , Shi Xiaofeng , Liu Xinyao , Qiao Xinrui , Zhou Xun , Li Hongmin , Du Yali , Chen Miao , Han Bing , Long Zhangbiao 
Published: March 2024

Abstract

Acquired pure red cell aplasia (PRCA) is anemia associated with the absence of erythroblasts and is characterized by persistent and easy recurrence. However, the underlying mechanisms of acquired PRCA remain obscure, and the role of gene mutations in the pathogenesis of acquired PRCA has not yet been reported. In the present study, we detected thirty newly diagnosed patients with acquired PRCA using whole exome sequencing, and a critical role for STK10 in acquired PRCA was uncovered. The mRNA levels of STK10 in three patients with STK10 mutations were decreased. These three patients had a poor response to immunosuppressive therapy and two died in the follow-up period. Here we report that knockdown of STK10 inhibits erythroid differentiation and promotes apoptosis of K562 cells. We show that knockdown of STK10 resulted in inhibition of ribosome biogenesis and reduced ribosome levels in K562 cells. We also show that the p53 signaling pathway is activated by knockdown of STK10. Our results imply that ribosome biogenesis downregulation together with pathological p53 activation prevents normal erythropoiesis. Our study uncovers a new pathophysiological mechanism leading to acquired PRCA driven by STK10 mutations.
Stefan Blowing Impact and Chemically Response of Rivlin-Reiner Fluid through Moving Rotating Convected Disk
Authors: Gangadhar Kotha , Subbarao K. , S T. Sujana , Wakif Abderrahim 
Published: March 2024

Abstract

The present investigation of rotating disk system had high significance due to its many applications like that fluid thermal reactors, regulations in fluidics systems, and fluid stirring. Subject to upper functions of rotating disk, this consequences on Stefan blowing into the three-dimensional Reiner-Rivlin (R-R) fluid flow by the rotating disk affecting on the vertical direction. Thermal radiation and Cattaneo-Christov (CC) energy diffusions form was incubate into consider energy transport. This Chemical reaction is accommodated by concentration equation. These convective boundary conditions are considered by disk surfaces. The ensuing nonlinear systems are determining applying the shooting method. These obtained outcomes are visualized graphically with physical justification. The results display to Reiner–Rivlin parameters caused the downturn on radial and tangential velocities profile as well as temperatures field, both vertical movement of this disk or not movement along the noted variation in numerical values. The Curves on this temperature enhanced when the greater values of the radiations. Although this radiation fells in to this fluid surface, it enhanced the temperature on the liquid being hot particles strike the cool particles on fluid it enhanced the temperature of the liquid. This present model was calibrated into comparing the decreased model of the investigation to the previously presented article, and a close congruence was founded.
Improving on Admissible Estimators Under Entropy Loss Function
Authors: Jha Brijesh Kumar , Panda Akash Ashirbad , Biswas Mrinmay 
Published: March 2024

Abstract

Consider $k ~(\ge 2)$ independent populations $\Pi_1, \ldots,\Pi_k$, where each population $\Pi_i$ follows an exponential distribution with hazard rate ${\beta_i},$ ($i = 1,\ldots,k$). Let
$X_{i1},\ldots, X_{in}$ represent a random sample
of size $n$ drawn from the $i$th population $\Pi_i$, where
$i = 1,\ldots,k.$ For each $i = 1,\ldots,k$, consider
$X_i=\sum_{j=1}^nX_{ij}$. Based on a special case of Gupta's rule \cite{B6}, estimation of the hazard rate associated with the selected population is undertaken with respect to the entropy loss function. Several natural estimators of the hazard rate of the corresponding population are proposed. A natural estimator is proved to be minimax. Estimators improving upon the natural ones are obtained by using the method of differential inequalities. Additionally, simulations are performed to have a comparative study of the proposed estimators based on their risk values.\vspace{2mm}\noindent{\bf{Keywords:}} Hazard rate; Natural selection rule; Differential inequality; Entropy loss function; Brewster-Zidek technique.

\vspace{0.2cm}\noindent{\bf AMS subject classification (2020):} 62F07 ({\bf Primary}), 62F10, 62F15 ({\bf Secondary}).
A case study of applying wet top-feed vibro replacement stone columns as foundation support of fuel tank in the reclamation area
Authors: Jamsawang Pitthaya , Bergado Dennes T. , Voottipruex Panich , Baez Francisco , Jongpradist Pornkasem 
Published: March 2024

Abstract

This paper reports a case study of applying wet and top feed vibro replacement stone columns to support the 20-m-high fuel tank built on loose to medium sand deposits. The design considerations, installations, applications, field tests, correlations, and subsequent three-dimensional finite element analyses are presented. The soil profile of the case study comprised approximately 8 to 12 m thick loose to medium-dense silty sand layers with a high groundwater table. The 1-m-diameter stone columns were installed in a triangular pattern with a spacing of 2.1 m. The improvement depths were 8, 11, and 12 m. After construction was completed, quality assurance of the stone column installation by various field tests was performed. Based on the hydro test results, the improved ground could carry an allowable bearing capacity of 200 kPa transferred from the 20-m-high fuel tank and exhibited a maximum settlement of smaller than 50 mm, which met the design criteria of this project. Due to reasonable quality control during stone column installation, the tank’s tilt caused by the non-uniformity of the improved sands was negligible because it was lower than 10 mm. The enhanced strength ratio of the surrounding sands was 2 to 3 due to the desification effect. The simulated data confirmed the observed results, and the verification or confirmatory test results illustrated the successful applications of the vibro-replacement stone columns.
Failure mechanism investigation of tunnel face subjected to high hydraulic pressure
Authors: Zhang Junwei , Wang Junjie , Zeng Xutao , Chen Zhongwei 
Published: March 2024

Abstract

A huge amount of underwater ahead of tunnel face surges abruptly into the excavated cavern with respect to the high hydraulic pressure after the karst geology is penetrated. In order to avoid the construction accidents in tunneling, it is particularly important to investigate the failure mechanism of the tunnel face subjected to the high hydraulic pressure. To establish a water-surged model centered on the disturbed tunnel face, both the elastic-plastic stress and the high hydraulic pressure are considered simultaneously. Afterwards, a simplified analytical solution based on the Hoek-brown criterion is developed. An illustrative example is used to demonstrate the performance of the proposed solution. The simplified analytical solution derived in this study is validated by the numerical simulations. In addition, a series of numerical simulation are performed to investigate influencing factors of the disturbance zone range ahead of tunnel face. The results indicate the simplified analytical solution of the plastic zone ahead of tunnel face under the different supports can be applied for the stability of hydraulic tunnels, preliminarily estimate the failure zone ahead of tunnel face. The range of plastic zone ahead of tunnel face is greatly influenced by the tunneling radius, surrounding rock grade and the hydraulic pressure.
From Planning to Execution: The Advantage of Real-time Dynamic Navigation in the Extraction of Impacted Mandibular Third Molars
Authors: Xu Fangfang , Gong Yuxin , Sina Ahmadi , Wang Chunyan , Pouria Arian , Yu Ming , Tu Junbo , Na Sijia 
Published: March 2024

Abstract

Purpose: This study aimed to evaluate the clinical efficacy of applying Real-time Dynamic Navigation (RDN) in the extraction of deep horizontal mandibular impacted third molars, hypothesizing that RDN will reduce surgical time and minimize the risk of injury to adjacent anatomical structures.
Methods: A prospective study was conducted on 160 patients aged between 18 and 37 years old with deep horizontal impaction of the mandibular third molar. Participants were randomly assigned to either the experimental group (receiving RDN-assisted extractions) or the control group (undergoing traditional extraction methods). Preoperative planning utilized Cone Beam Computed Tomography (CBCT) and Mimics software for accurate localization and segmentation of impacted teeth. Parametric data were analyzed using an independent t-test for intergroup comparisons, with significance set at p < 0.05.
Results: The experimental group required an average of 11±1 minutes for preoperative planning using RDN, which was not a requirement for the control group. The setup of the navigation system took an average of 4±1 minutes in the experimental group and 0 minutes in the control group. The experimental group demonstrated a significantly shorter average surgical time of 22 ± 3 minutes compared to the control group's 36 ± 3 minutes. So, the differences preoperative design time, in surgical time, and complication rates between the two groups were statistically significant (p=0.005). Additionally, the RDN group reported no complications related to adjacent tooth damage or nerve injury, whereas the control group noted instances of adjacent tooth damage and lower lip discomfort, suggesting inferior alveolar nerve irritation.
Conclusion: Precise, Secure, R eal-time guidance that supports the application of RDN in complicated dental extractions and introduces a new era of oral and maxillofacial surgery.
On the logarithmic stability estimates of non-autonomous systems: applications to control systems
Authors: Jammazi Chaker , Bouameid Ghada , Boutayeb Mohamed 
Published: March 2024

Abstract

This paper concerns the polynomial-logarithmic stability and stabilization oftime-varying control systems. We present sufficient Lyapunov-like conditionsguaranteeing this polynomial-logarithmic stability with applications to several linearand nonlinear control systems.
Patients with Omicron variant infection can safely undergo elective orthopedic surgery: a retrospective cohort study
Authors: Sun Yinsong , Dong Mingfei , Liao Junyi , Li Ke , Xu Wei , Chen Hong , Zhou Lu , Lei Yiting , Huang Wei 
Published: March 2024

Abstract

Background
COVID-19 is believed to be associated with significantly increased risks of morbidity and mortality. However, there are lack of reports on how infection with the COVID-19 Omicron variant affects the perioperative prognosis. Therefore, this study sought to find out perioperative differences in laboratory test results and complications between orthopedic surgery patients who were COVID-19 positive and negative at admission, to explore whether patients infected with the Omicron variant need to delay their orthopedic elective surgery.
Methods
A single-center cohort study of 54 orthopedic inpatients with COVID-19 Omicron variant infection were 1:1 matched to those who did not have a history of COVID-19, laboratory parameters including blood routine, inflammatory factors, coagulogram markers and postoperative complications were recorded and compared.
Results
Differences can not be found in the incidence of perioperative complications and mortality rates between the group infected with the SARS-CoV-2 Omicron variant and the uninfected group, as well as no statistical differences in laboratory test indicators.
Conclusions
The SARS-CoV-2 Omicron variant does not appear to pose a huge threat to elective orthopedic surgery, patients with Omicron variant infection can safely undergo elective orthopedic surgery without delay.
Epidemiological Characteristics and Genotypic Features of Rotavirus and Norovirus in Jining City, 2021-2022
Authors: Wu Changjing , Fu Zhongyan , Xie Cuihua , Zhao Jian , He Feifei , Jiao Boyan , Jiao Baihai 
Published: March 2024

Abstract

Background Diarrhea, often caused by viruses like Rotavirus (RV) and Norovirus (NV), is a global health concern. This study focuses on RV and NV in Jining City from 2021 to 2022.Methods Between 2021 and 2022, a total of 1052 diarrhea samples were collected. Real-time PCR was used to detect RV-A, NV GI, and NV GII. For RV-A positive samples, VP7 and VP4 genes were sequenced for genotype analysis, followed by the construction of evolutionary trees. Likewise, for NV GII positive samples, VP1 and RdRp genes were sequenced for genotypic analysis, and evolutionary trees were subsequently constructed.Resuts : Between 2021 and 2022, Jining City showed varying detection ratios: RV-A (7.03%), NV GI (0.10%), NV GII (5.42%), and co-infection of RV-A and NV GII (1.14%). The highest RV-A ratios were shown in ≤ 1 year and 2–5-year age groups. Jinxiang County and Liangshan County had notably high RV-A ratios at 24.37% and 18.33% respectively. Qufu and Weishan had no RV-A positives. Weishan showed the highest NV GII ratios at 35.48%. Genotype analysis showed that, in 2021, G9P[8] and G2P[4] were dominant at 94.44% and 5.56% respectively. In 2022, G8P[8], G9P[8], and G1P[8] were prominent at 75.86%, 13.79%, and 10.34% respectively. In 2021, GII.3[P12], GII.4[P16], and GII.4[P31] constituted 71.43%, 14.29%, and 14.29% respectively. In 2022, GII.3[P12] and GII.4[P16] accounted for 55.00% and 45.00% respectively.Conclusions RV-A and NV showed varying patterns in different time frames, age groups, and regions. Genotypic shifts were also observed in prevalent RV-A and NV GII strains in Jining City from 2021 to 2022. Ongoing monitoring of RV-A and NV is recommended for effective prevention and control.
Shock index to predict outcomes in patients with trauma following traffic collisions: a retrospective cohort study
Authors: Liao Te-Kai , Ho Chung-Han , Lin Ying-Jia , Cheng Li-Chin , Huang Hsuan-Yi 
Published: March 2024

Abstract
Purpose:Taiwan, which has a rate of high vehicle ownership, faces significant challenges in managing trauma caused by traffic collisions. In Taiwan, traffic collisions contribute significantly to morbidity and mortality, with a high incidence of severe bleeding trauma. The shock index (SI) and the modified shock index (MSI) have been proposed as early indicators of hemodynamic instability. In this study, we aimed to assess the efficacy of SI and MSI in predicting adverse outcomes in patients with trauma following traffic collisions.
Methods: This retrospective cohort study was conducted at Chi Mei Hospital from January 2015 to December 2020. The comprehensive analysis included 662 patients, with data collected on vital signs and outcomes such as mortality, blood transfusion, emergent surgical intervention (ESI), transarterial embolization (TAE), and intensive care unit (ICU) admission. Optimal cutoff points for SI and MSI were identified by calculating the Youden index. Logistic regression analysis was used to assess outcomes, adjusting for demographic and injury severity variables.
Results:An SI threshold of 1.11 was associated with an increased risk of mortality, while an SI of 0.84 predicted the need for blood transfusion in the context of traffic collisions. Both SI and MSI demonstrated high predictive power for mortality and blood transfusion, with acceptable accuracy for TAE, ESI, and ICU admission. Logistic regression analyses confirmed the independence of SI and MSI as risk factors for adverse outcomes, thus, providing valuable insights into their clinical utility.
Conclusions:SI and MSI are valuable tools for predicting mortality and blood transfusion needs in patients with trauma due to traffic collisions. These findings advance the quality of care for patients with trauma during their transition from the emergency room to the ICU, facilitating prompt and reliable decision-making processes and improving the care of patients with trauma.
Correlations between spinopelvic parameters and health-related quality of life in degenerative lumbar scoliosis patients before and after surgery
Authors: Zhang Jiaqi , Liu Yinhao , Zeng Yan , Yuan Lei , Li Weishi 
Published: March 2024

Abstract
Background For degenerative lumbar scoliosis (DLS) , prior studies mainly focused on the preoperative relationshipbetween spinopelvic parameters and health-related quality of life (HRQoL), lacking an exhaustive evaluation of the postoperative situation. Therefore, the postoperative parameters most closely bonded with clinical outcomes has not yet been well-defined in DLS patients. The objective of this study was to comprehensively assess the correlation between radiographic parameters and HRQoL before and after surgery, and to identified the most valuable spinopelvic parameters for postoperative curative effect.
Methods This study retrospectively reviewed 130 consecutive patients who underwent long-level fusion with at least 1 year follow-up. Standing whole-spine radiographs and HRQoL measurements were examined preoperatively and at final follow-up. Spinopelvic parameters included thoracic kyphosis (TK), thoracolumbar kyphosis (TLK), lumbar lordosis (LL), pelvic incidence minus lumbar lordosis (PI-LL), pelvic tilt (PT), pelvic incidence (PI), sacral slope (SS), sagittal vertical axis (SVA), T1 pelvic angle (TPA), Global tilt (GT), Cobb angle (CA), apical vertebral translation (AVT) and coronal vertical axis (CVA). HRQoL was evaluated using the Visual Analogue Scale (VAS), Oswestry Disability Index (ODI), Chinese version of Lumbar Stiffness Disability Index (C-LSDI), Japanese Orthopedic Association-29 (JOA-29), Scoliosis Research Society-22 (SRS-22),and the 36-item Short Form Health Survey (SF-36) total and subscale scores. Pearson’s correlation analysis was performed to determine relationships between them.
Results The study population included 104 women and 26 men with an average age of 62.9 years. Both coronal and sagittal parameters showed significant correlations with HRQoL scores pre- and post-operatively. Among the coronal parameters, only CA showed correlations with SRS-22 subscale scores, and its correlation with Self-image scores were observed both before and after surgery. Among sagittal parameters, PT, PI-LL, LL, SVA, TPA, and GT showed significant correlations with HRQoL before surgery, including ODI, JOA-29, and SF-36 PCS. At final follow-up, except for AVT, CVA, and LL, all other sagittal parameters were significantly correlated with HRQoL.
Conclusions HRQoL scores not only correlated with radiological parameters before surgery, but also after long-term follow-up. Besides, sagittal parameters, especially postoperative PI-LL, SVA, TPA, GT, were more closely correlated with clinical outcome measurements.
Sliding mode preview control based consensus for nonlinearmulti-agent systems
Authors: Lan Yonghong , Zheng Shikang , Zheng Litao 
Published: March 2024

Abstract
In this paper, the design of sliding mode preview control (SMPC) based consensus for nonlinear multi-agent systems (MASs) is presented. First, a novel preview information-based equality constraint is introduced and an augmented error system is constructed for each follower agent. Next, a distributed SMPC strategy is proposed by designing integral-type sliding function. Thereafter, the preview control (PC) law design problem is transformed into the stability problem of the augmented system and a linear matrix inequality (LMI) based sufficient condition is given, which can guarantee the states of all agents achieving tracking consensus and ensure a guaranteed level of performance on sliding surface. A distributed adaptive sliding mode control (SMC) law is synthesized such that the sliding surface is reachable. Further, by employing the Lyapunov theory together with mathematical analysis, the gains of the controller can be obtained. Finally, two simulation examples demonstrate the effectiveness and superiority of the developed method.
Comparison of testing methods assessing the in vitro efficacy of the combination of aztreonam with avibactam on multidrug-resistant Gram-negative bacilli
Authors: Deckers Corentin , Bélik Florian , Denis Olivier , Bogaerts Pierre , Montesinos Isabel , Berhin Catherine , Bouchahrouf Warda , Hoebeke Martin , Evrard Stéphanie , Gilliard Nicolas , Okur Merve , Huang Te-Din 
Published: March 2024

Abstract
Background Aztreonam-avibactam (ATM-AVI) combination shows promising effectiveness on most carbapenemase-producing Gram-negatives, yet standardized antibiotic susceptibility testing (AST) methods for evaluating the combination in clinical laboratories is lacking. We aimed to evaluate different ATM-AVI AST approaches.Methods 96 characterized carbapenem-resistant clinical isolates belonging to 9 Enterobacterales (EB; n = 80) and P. aeruginosa (PA; n = 16) species, including 90 carbapenemase producers and 72 strains resistant to both CAZ-AVI and ATM, were tested. Paper disk elution (DE; Bio-Rad) and E-test gradient strips stacking (SS; bioMérieux) were performed for the ATM + CAZ-AVI combination. MIC Test Strip (MTS; Liofilchem) was evaluated for ATM-AVI MIC determination. Results were interpreted applying ATM clinical breakpoints of the EUCAST guidelines to assess the combinations and compared to the broth microdilution (BMD) method using Sensititre panels (Thermofisher).Results According to the reference BMD, 93% of EB and 69% of PA were tested susceptible to ATM-AVI. The synergistic effect of ATM-AVI was of 95% for EB, but of only 17% for PA. Higher categorical and essential agreement (CA / EA) rates were obtained with the MTS method for both EB (89% / 91%) and PA (94% / 94%) compared to those of SS (87% / 83% for EB; 81% / 81% for PA). MTS and SS yielded 2 and 3 major discrepancies (MD), respectively, while 3 very major discrepancies (VMD) each were observed for both methods. Concerning the DE method, CA reached 91%, for EB and 81% for PA, but high number of VMD were observed for EB (n = 6; 8%) and for PA (n = 3; 19%).Conclusions The ATM-AVI association displayed excellent in vitro activity against highly resistant clinical Enterobacterales strains. MTS method offers accurate ATM-AVI AST results, while the SS method might serve as better alternative then DE method in assessing the efficacy of ATM + CAZ-AVI combination. However, further investigation is needed to confirm the methods' ability to detect ATM-AVI resistance.
Developing a Mixed Matrix Membrane (MMM) based on Nanoclay modified with Chitosan for the elimination of Methylene Blue (MB) from aquatic area
Authors: Hajivar Zahra Badri , Rostami Elham , Kiasat Alireza 
Published: March 2024

Abstract
There is a serious health threat to humans, plants, and animals in developing countries due to water pollution. In order to achieve the best results, it is recommended that membranes be prepared with a long life, acceptable color removal efficiency, as well as anti-clogging properties. A polyethersulfone membrane solution was first prepared by adding montmerillonite clay nanoparticles (NPs) modified with chitosan to a polyethersulfone membrane solution at different weight percentages. An investigation was conducted into the effect of additive nanoparticles on mechanical properties, structural characteristics, and flux rejection and recovery of membranes. The water flux of this membrane is acceptable when compared to the polyethersulfone membrane due to its hydrophilicity, resistance, and Methylene Blue (MB) as cationic dye elimination (94%). The modified polyethersulfone membrane also performs better in terms of water flux recovery than the unmodified polyethersulfone membrane. This means that dye removal is enhanced by NPs.