bluuebunny/crossref_metadata_2025_split huggingface dataset:
Charge‐Reversed Exosomes for Targeted Gene Delivery to Cartilage for Osteoarthritis Treatment
Authors: Zhang Chenzhen , Pathrikar Tanvi V. , Baby Helna M. , Li Jun , Zhang Hengli , Selvadoss Andrew , Ovchinnikova Arina , Ionescu Andreia , Chubinskaya Susan , Miller Rachel E. , Bajpayee Ambika G. 
Published: April 2024

AbstractGene therapy has the potential to facilitate targeted expression of therapeutic proteins to promote cartilage regeneration in osteoarthritis (OA). The dense, avascular, aggrecan‐glycosaminoglycan (GAG) rich negatively charged cartilage, however, hinders their transport to reach chondrocytes in effective doses. While viral vector mediated gene delivery has shown promise, concerns over immunogenicity and tumorigenic side‐effects persist. To address these issues, this study develops surface‐modified cartilage‐targeting exosomes as non‐viral carriers for gene therapy. Charge‐reversed cationic exosomes are engineered for mRNA delivery by anchoring cartilage targeting optimally charged arginine‐rich cationic motifs into the anionic exosome bilayer by using buffer pH as a charge‐reversal switch. Cationic exosomes penetrated through the full‐thickness of early‐stage arthritic human cartilage owing to weak‐reversible ionic binding with GAGs and efficiently delivered the encapsulated eGFP mRNA to chondrocytes residing in tissue deep layers, while unmodified anionic exosomes do not. When intra‐articularly injected into destabilized medial meniscus mice knees with early‐stage OA, mRNA loaded charge‐reversed exosomes overcame joint clearance and rapidly penetrated into cartilage, creating an intra‐tissue depot and efficiently expressing eGFP; native exosomes remained unsuccessful. Cationic exosomes thus hold strong translational potential as a platform technology for cartilage‐targeted non‐viral delivery of any relevant mRNA targets for OA treatment.
A Novel Asymmetric Interior Permanent Magnet Machine with Auxiliary Flux Barriers
Authors: Li Shihao , Di Chong , Bao Xiaohua 
Published: April 2024

AbstractA novel asymmetric interior permanent magnet (AIPM) machine is proposed in this paper. The machine's rotor consists of asymmetric poles and auxiliary flux barriers. The torque ripple of the machine is weakened by the asymmetric design of the left and right sides of the magnetic poles. The magnetic‐field‐shifting (MFS) effect improves the electromagnetic torque after adding the auxiliary flux barrier to shift the magnetic axis. The influence of critical geometrical parameters on the electromagnetic performance of the machine is investigated under the condition that the stator and permanent magnet volume remain unchanged. The relevant geometrical parameters of the machine are optimized and designed through the improved Taguchi method. The performance of the AIPM machine and the conventional machine under no‐load and load conditions are further compared by simulation analysis with finite elements, verifying the increase in electromagnetic torque and the reduction in torque ripple. © 2024 Institute of Electrical Engineers of Japan and Wiley Periodicals LLC.
Potato protein hydrolysate inhibits RANKL‐induced osteoclast development by inhibiting osteoclastogenic genes via the NF‐κB/MAPKs signaling pathways
Authors: Chen Yi‐Ju , He Yen‐Hua , Lo Yun‐Hsin , Yang Hong‐Siang , Abomughaid Mosleh Mohammad , Kumar K. J. Senthil , Lin Wan‐Teng 
Published: April 2024

AbstractIn recent times, there has been growing attention towards exploring the nutritional and functional aspects of potato protein, along with its diverse applications. In the present study, we examined the anti‐osteoclast properties of potato protein hydrolysate (PP902) in vitro. Murine macrophages (RAW264.7) were differentiated into osteoclasts by receptor activator of nuclear factor‐κB ligand (RANKL), and PP902 was examined for its inhibitory effect. Initially, treatment with PP902 was found to significantly prevent RANKL‐induced morphological changes in macrophage cells, as determined by tartrate‐resistant acid phosphatase (TRAP) staining analysis. This notion was further supported by F‐actin analysis using a confocal microscope. Furthermore, PP902 treatment effectively and dose‐dependently down‐regulated the expression of RANKL‐induced osteoclastogenic marker genes, including TRAP, CTR, RANK, NFATc1, OC‐STAMP, and c‐Fos. These inhibitory effects were associated with suppressing NF‐κB transcriptional activation and subsequent reduced nuclear translocation. The decrease in NF‐κB activity resulted from reduced activation of its upstream kinases, including I‐κBα and IKKα. Moreover, PP902 significantly inhibited RANKL‐induced p38MAPK and ERK1/2 activities. Nevertheless, PP902 treatment prevents RANKL‐induced intracellular reactive oxygen species generation via increased HO‐1 activity. The combined antioxidant and anti‐inflammatory effects of PP902 resulted in significant suppression of osteoclastogenesis, suggesting its potential as an adjuvant therapy for osteoclast‐related diseases.
Use of autologous pericardial patch graft for treatment of large congenital peritoneopericardial diaphragmatic hernia in two cats
Authors: Aguilar García Daniel , Jiménez Peláez Manuel 
Published: April 2024

AbstractPeritoneopericardial diaphragmatic hernia is a congenital structural anomaly that results in a communication between the pericardial sac and the peritoneal cavity. About 50% of cats are asymptomatic at the time of diagnosis, and the remaining animals may show respiratory (dyspnoea, tachypnoea, exercise intolerance), gastrointestinal, cardiac tamponade or non‐specific clinical signs. Median celiotomy for herniorrhaphy without tension (primary closure, muscle flaps, synthetic mesh, pericardium) is the treatment of choice for symptomatic patients. Two cats were referred with respiratory signs, secondary to a peritoneopericardial diaphragmatic hernia. A pericardial patch graft was obtained and sutured to the diaphragm as an alternative technique to close the large defect and not cause excessive tension on the diaphragm and caval foramen. Patients recovered well without any complications after surgery. Re‐examination and thoracic radiographs at 1 week, 2 weeks, 3 months, 6 months and 3 years postoperatively showed no signs of recurrence and the patients remained asymptomatic.
Green New Deals in comparative perspective
Authors: Green Fergus 
Published: April 2024

AbstractIn February 2019, Representative Alexandria Ocasio‐Cortez and Senator Ed Markey introduced into the US Congress a non‐binding resolution for a Green New Deal, with the aim to catalyze policies and programs to rapidly decarbonize the US economy while achieving wider progressive economic, social and environmental goals. This motion sparked widespread interest, in and beyond the US, in the potential for more ambitious and solidaristic climate policy under the banner of a Green New Deal (GND). This Overview, after introducing the history of the GND concept and exploring its dimensions in theory, provides a snapshot of GNDs proposed (or adopted/enacted) by politicians, candidates for political office, political parties and governments around the world in the period 2019–2022. Drawing on theories of comparative politics and comparative political economy, the Overview illuminates key patterns in the prevalence and content of this set of GND proposals, as well as their ideological underpinnings and implicit “theories of change.” Specifically, it ventures that: GND policies are more commonly proposed in high‐income, industrialized democracies; variation in GNDs' prevalence and content are associated with varieties of capitalism and electoral institutions; GND policies are more commonly proposed by left‐of‐center parties and candidates; and GNDs are being proposed at all levels of government, but their content is shaped by constraints on government powers. On the basis of this analysis, the concluding section proposes a detailed research agenda on GNDs, with an emphasis on comparative research.This article is categorized under:
The Carbon Economy and Climate Mitigation > Benefits of Mitigation
Policy and Governance > National Climate Change Policy
Policy and Governance > Multilevel and Transnational Climate Change Governance
Spatial analysis toolkits for RNA in situ sequencing
Authors: Chen Jiayu , Ke Rongqin 
Published: April 2024

AbstractSpatial transcriptomics (ST) is featured by high‐throughput gene expression profiling within their native cell and tissue context, offering a means to investigate gene regulatory networks in tissue microenvironment. In situ sequencing (ISS) is an imaging‐based ST technology that simultaneously detects hundreds to thousands of genes at subcellular resolution. As a highly reproducible and robust technique, ISS has been widely adapted and undergone a series of technical iterations. As the interest in ISS‐based spatial transcriptomic analysis grows, scalable and integrated data analysis workflows are needed to facilitate the applications of ISS in different research fields. This review presents the state‐of‐the‐art bioinformatic toolkits for ISS data analysis, which covers the upstream and downstream analysis workflows, including image analysis, cell segmentation, clustering, functional enrichment, detection of spatially variable genes and cell clusters, spatial cell–cell interactions, and trajectory inference. To assist the community in choosing the right tools for their research, the application of each tool and its compatibility with ISS data are reviewed in detailed. Finally, future perspectives and challenges concerning how to integrate heterogeneous tools into a user‐friendly analysis pipeline are discussed.This article is categorized under:
RNA Methods > RNA Analyses In Vitro and In Silico
Promoting the potabilization of drinking water at home using local materials as an alternative solution for combating waterborne diseases: Socioeconomic feasibility study in Dschang, West Cameroon
Authors: Pokam Djoko Godfroy Rostant , Ntangmo Tsafack Honorine , Wandji Kwekap Julie , Wamba Franck Robean , Foyet Juluis Visnel , Temgoua Emile 
Published: April 2024

AbstractThis study aimed to assess the socioeconomic feasibility of promoting locally produced water filters to promote their local production. It appears that 69.8% of participants did not know that water filters were produced locally and 92.3% were ready to buy them with efficiency as the main motivation (39.8%). In addition, being aged [46–60 years old] (OR = 19.17; IC = 3.13–37.81; p = 0.008), being female (OR = 1.67; IC = 1.02–2.77; p = 0.041), student/pupil (OR = 2.32; IC = 1.13–4.78; p = 0.021), employed in the private sector (OR = 3.68; IC = 1.32–11.16; p = 0.015), and civil servant (OR = 3.28; IC = 1.09–10.99; p = 0.041) significantly increased the odds of having ever used a water filter in their household. In addition, we found that 71.7% of participants had ever used an imported ceramic water filter in their households and the main reason given by these participants for abandoning or renewing these filters within their households was that they felt that they had already become old and inefficient. The valorization of locally manufactured filters could therefore constitute a logical alternative that can contribute to solving a certain number of socioeconomic and health problems in our country.
Orbital angular momentum small-x evolution: exact results in the large-Nc limit
Authors: Manley Brandon 
Published: April 2024

Abstract
We construct an exact solution to the revised small-x orbital angular momentum (OAM) evolution equations derived in [1], based on an earlier work [2]. These equations are derived in the double logarithmic approximation (summing powers of αs ln2(1/x) with αs the strong coupling constant and x the Bjorken x variable) and the large-Nc limit, with Nc the number of quark colors. From our solution, we extract the small-x, large-Nc expressions of the quark and gluon OAM distributions. Additionally, we determine the large-Nc small-x asymptotics of the OAM distributions to be$$ {L}_{q+\overline{q}}\left(x,{Q}^2\right)\sim {L}_G\left(x,{Q}^2\right)\sim \Delta \Sigma \left(x,{Q}^2\right)\sim \Delta G\left(x,{Q}^2\right)\sim {\left(\frac{1}{x}\right)}^{\alpha_h}, $$

L

q
+

q
¯

x

Q
2

∼

L
G

x

Q
2

∼
ΔΣ

x

Q
2

∼
Δ
G

x

Q
2

∼

1
x

α
h

,
with the intercept αh the same as obtained in the small-x helicity evolution [3], which can be approximated as αh ≈ $$ 3.66074\sqrt{\frac{\alpha_s{N}_c}{2\pi }} $$
3.66074

α
s

N
c

2
π

. This result is in complete agreement with [4]. Additionally, we calculate the ratio of the quark and gluon OAM distributions to the flavor-singlet quark and gluon helicity parton distribution functions respectively in the small-x region.
The QCD axion sum rule
Authors: Gavela Belén , Quílez Pablo , Ramos Maria 
Published: April 2024

Abstract
We demonstrate that the true QCD axion that solves the strong CP problem can be found in all generality outside the customary standard QCD band, with QCD being the sole source of Peccei-Quinn breaking. The essential reason is that the basis of axion-gluon interactions does not need to coincide with the mass basis. Specifically, we consider the case in which the QCD axion field is not the only singlet scalar in Nature but it mixes with other singlet scalars (besides the η′). We determine the exact mathematical condition for an arbitrary N-scalar potential to be Peccei-Quinn invariant. Such potentials provide extra sources of mass for the customary axion without enlarging the Standard Model gauge symmetry. The contribution to the axion mass stemming from the QCD topological susceptibility is shown to be shared then among the N axion eigenstates through a precise sum rule. Their location can only be displaced to the right of the standard QCD band. We demonstrate that the axion closest to this band can be displaced from it by a factor of $$ \sqrt{N} $$

N

at most, and this corresponds to the case in which all axion signals are maximally deviated. Conversely, if one axion is found on the standard QCD band, the other eigenstates will be out of experimental reach. Our results imply that any ALP experiment which finds a signal to the right of the standard QCD axion band can be solving the strong CP problem within QCD, with the associated N − 1 excitations to be found in an area of parameter space that we determine. We illustrate the results and phenomenology in some particular cases.
Kerr binary dynamics from minimal coupling and double copy
Authors: Alessio Francesco 
Published: April 2024

Abstract
We construct a new Yang-Mills Lagrangian based on a notion of minimal coupling that incorporates classical spin effects. The construction relies on the introduction of a new covariant derivative, which we name “classical spin covariant derivative”, that is compatible with the three-point interaction of the $$ \sqrt{\textrm{Kerr}} $$

Kerr

solution with the gauge field. The resulting Lagrangian, besides the correct three-point coupling, predicts a unique choice for contact terms and therefore it can be used to compute higher-point amplitudes such as the Compton, unaffected by spurious poles. Using double copy techniques we use this theory to extract gravity amplitudes and observables that are relevant to describe Kerr binary dynamics to all orders in the spin. In particular, we compute the 2PM ($$ \mathcal{O} $$
O
($$ {G}_N^2 $$

G
N
2

)) 2 → 2 elastic scattering amplitude between two classically spinning objects to all orders in the spin and use it to extract the 2PM scattering angle.
Crossing beyond scattering amplitudes
Authors: Caron-Huot Simon , Giroux Mathieu , Hannesdottir Holmfridur S. , Mizera Sebastian 
Published: April 2024

Abstract
We find that different asymptotic measurements in quantum field theory can be related to one another through new versions of crossing symmetry. Assuming analyticity, we conjecture generalized crossing relations for multi-particle processes and the corresponding paths of analytic continuation. We prove them to all multiplicity at tree-level in quantum field theory and string theory. We illustrate how to practically perform analytic continuations on loop-level examples using different methods, including unitarity cuts and differential equations. We study the extent to which anomalous thresholds away from the usual physical region can cause an analytic obstruction to crossing when massless particles are involved. In an appendix, we review and streamline historical proofs of four-particle crossing symmetry in gapped theories.
Evolution of parton distribution functions in the short-distance factorization scheme
Authors: Dutrieux Hervé , Karpie Joseph , Monahan Christopher , Orginos Kostas , Zafeiropoulos Savvas ,   on behalf of the HadStruc collaboration
Published: April 2024

Abstract
Lattice QCD offers the possibility of computing parton distributions from first principles, although not in the usual $$ \overline{MS} $$

MS
¯

factorization scheme. Calculations are therefore matched to $$ \overline{MS} $$

MS
¯

using a perturbative procedure which is the source of significant uncertainty within the currently accessible kinematics. We present the possibility of computing the z2 evolution of non-singlet pseudo-parton distribution functions within the short factorization scheme in a numerically improvable way. The goal is to have tools to evolve a calculation to a scale where perturbative uncertainties are less pronounced. We compare a numerical extraction of the evolution operator from lattice data to the computation of z2 dependence in perturbation theory. Finally, we discuss how this numerical work may be extended to address the two-scale problem that arises when the Ioffe time range must be made large to extend the reach of the calculation of the pseudo-PDF to smaller values of the momentum fraction.
Länger gesund im Beruf? Trends in den Lebensjahren frei von Herz-Kreislauf- und Muskel-Skelett-Erkrankungen in GKV-Daten für die Erwerbstätigen- und Allgemeinbevölkerung
Authors: Tetzlaff Juliane , Epping Jelena 
Published: April 2024

Zusammenfassung
Hintergrund
Unsere Studie fokussiert auf die Entwicklung der erkrankungsfreien Lebensjahre in Bezug auf 2 Erkrankungsgruppen mit hoher Public-Health-Relevanz: Muskel-Skelett- (MSE) und Herz-Kreislauf-Erkrankungen (HKE). Vor dem Hintergrund der steigenden Lebensarbeitszeit wird die Entwicklung der erkrankungsfreien Jahre der Bevölkerung im erwerbsfähigen Alter und der Erwerbstätigen verglichen und Unterschiede zwischen den Berufsgruppen beleuchtet.

Methoden
Die Studie basiert auf den Daten der AOK Niedersachsen (N = 2.001.225). Die Erkrankungsfälle werden anhand der Diagnosedaten ermittelt. Die erwarteten Jahre frei von MSE und HKE werden mit Multistate-Life-Table-Analysen für 3 Perioden zwischen 2006 und 2018 berechnet. Die Berufsgruppe wird über den Berufsschlüssel definiert und in 3 Gruppen unterteilt: 1) Un- und Angelernte, 2) Fachkräfte und Spezialisten, 3) Hochqualifizierte.

Ergebnisse
Die Lebensjahre frei von MSE nahmen in der Allgemeinbevölkerung und unter den Erwerbstätigen deutlich ab. Die stärkste Verringerung zeigte sich in der höherqualifizierten Berufsgruppe. Die Lebensjahre frei von HKE stiegen in der Allgemeinbevölkerung im Zeitverlauf. Die Zunahmen waren unter den Erwerbstätigen geringer, sie wurden nur bei Männern in un- und angelernter Tätigkeit verzeichnet.

Diskussion
Die Studie zeigt, dass sich die erkrankungsfreien Jahre unter den Erwerbstätigen teilweise schlechter als in der Allgemeinbevölkerung entwickelten. Für die untersuchten Erkrankungsgruppen MSE und HKE bestehen deutliche Ungleichheiten zwischen den Berufsgruppen, die sich im Zeitverlauf etwas verringerten. Die Ungleichheiten und die Abnahme der Jahre frei von MSE belegen die hohe Public-Health-Relevanz und den Bedarf an Präventionsmaßnahmen zur Vermeidung von HKE und MSE im erwerbsfähigen Alter.
BoostTrack: boosting the similarity measure and detection confidence for improved multiple object tracking
Authors: Stanojevic Vukasin D. , Todorovic Branimir T. 
Published: April 2024

AbstractHandling unreliable detections and avoiding identity switches are crucial for the success of multiple object tracking (MOT). Ideally, MOT algorithm should use true positive detections only, work in real-time and produce no identity switches. To approach the described ideal solution, we present the BoostTrack, a simple yet effective tracing-by-detection MOT method that utilizes several lightweight plug and play additions to improve MOT performance. We design a detection-tracklet confidence score and use it to scale the similarity measure and implicitly favour high detection confidence and high tracklet confidence pairs in one-stage association. To reduce the ambiguity arising from using intersection over union (IoU), we propose a novel Mahalanobis distance and shape similarity additions to boost the overall similarity measure. To utilize low-detection score bounding boxes in one-stage association, we propose to boost the confidence scores of two groups of detections: the detections we assume to correspond to the existing tracked object, and the detections we assume to correspond to a previously undetected object. The proposed additions are orthogonal to the existing approaches, and we combine them with interpolation and camera motion compensation to achieve results comparable to the standard benchmark solutions while retaining real-time execution speed. When combined with appearance similarity, our method outperforms all standard benchmark solutions on MOT17 and MOT20 datasets. It ranks first among online methods in HOTA metric in the MOT Challenge on MOT17 and MOT20 test sets. We make our code available at https://github.com/vukasin-stanojevic/BoostTrack.
On the Continuity of the Projection Mapping from Strategic Measures to Occupation Measures in Absorbing Markov Decision Processes
Authors: Piunovskiy Alexey , Zhang Yi 
Published: April 2024

AbstractIn this paper, we prove the following assertion for an absorbing Markov decision process (MDP) with the given initial distribution, which is also assumed to be semi-continuous: the continuity of the projection mapping from the space of strategic measures to the space of occupation measures, both endowed with their weak topologies, is equivalent to the MDP model being uniformly absorbing. An example demonstrates, among other interesting scenarios, that for an absorbing (but not uniformly absorbing) semi-continuous MDP with the given initial distribution, the space of occupation measures can fail to be compact in the weak topology.
2D Smagorinsky-Type Large Eddy Models as Limits of Stochastic PDEs
Authors: Flandoli Franco , Luo Dejun , Luongo Eliseo 
Published: April 2024

AbstractWe prove that a version of Smagorinsky large eddy model for a 2D fluid in vorticity form is the scaling limit of suitable stochastic models for large scales, where the influence of small turbulent eddies is modeled by a transport-type noise.