bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis and reactivity of N‐[α‐acetoxy)‐4‐pyridylmethyl]‐3,5‐dimethylbenzamide
Authors: Braña Miguel F. , Rodriquez María L. LÓPez 
Published: March 2009

AbstractThe synthesis of N‐[(α‐acetoxy)‐4‐pyridylmethyl]‐3,5‐dimethylbenzamide (4) and its reactivity are described. Since the acetoxy is a good leaving group, 4 gives SN processes easily.
Phenalenones. IV. Heterocycles from 3‐hydroxyphenalenone (I)
Authors: Kuroki Masatane , Terachi Yasuhito , Tsunashima Yutaka 
Published: March 2009

Abstract3‐Hydroxyphenalenone reacts with o‐disubstituted benzenes (substituents: NH2, OH, CH2OH and SH), aliphatic and aromatic aldehydes to give the various heterocyclic compounds which are fused with phenalene ring. These reactions resemble those of 1,3‐cyclohexanediones in many respects.
Synthesis of s‐triazolo[4,3‐b]pyridazine C‐nucleosides
Authors: Legraverend Michel , Bisagni Emile , Lhoste Jean‐Marc 
Published: March 2009

AbstractA one step synthesis of s‐triazolo[4,3‐b]pyridazine using 3‐chloro‐6‐hydrazinopyridazine and an appropriate thioformimidate is described. Applying this procedure to 5‐O‐benzoyl‐1‐benzylthio‐1‐formimidate‐D‐ribofuranose, 5′ benzoyl‐6‐chloro‐3β‐D‐ribofuranosyl‐s‐triazolo[4,3‐b]pyridazine was obtained. Substitutions of chlorine by nucleophilic reagents afforded some derivatives of a new series of C‐nucleo‐sides. Structural determination including anomeric configuration assignment is discussed based mainly on 1H nmr spectroscopy.
Chemistry of 1,2,3‐thiadiazole. IV. Synthesis of [1]benzoxepino‐[3,4‐d][1,2,3]thiadiazole, [1]benzothiepino‐[3,4‐d][1,2,3]thiadiazole, [1]benzoxepino[4,3‐d][1,2,3]thiadiazole, [1]benzoxepino[4,3‐d]oxazole and [1]benzoxepino[4,3‐d]oxazole. Four novel heterocycles
Authors: Shafiee A. , Kiaeay G. 
Published: March 2009

AbstractStarting from the readily available 4‐bromomethy‐5‐carbethoxy 1,2,3‐thiadiazole (V), 5‐bromomethy‐4‐carbethoxy‐1,2,3‐thiadiazole (IX) and ethyl 2‐aryl‐5‐bromomethyloxazole‐4‐carboxylate (XIV), 4,10‐dihydro‐10‐oxo[1]benzoxepino[3,4‐d][1,2,3]thiadiazole (Ia), 4,10‐dihydro‐10‐oxo[1]benzothiepino[3,4‐d][1,2,3]thiadiazole (Ib), 4,10‐dihydro‐4‐oxo[1]benzothiepino[4,3‐d] [1,2,3]thiazole (II), 2‐aryl‐4,10‐dihydro‐4‐oxo[1]benzoxepino[4,3‐d]oxazoles (XIXa‐XIXc) and 2‐aryl‐4,10‐dihydro‐4‐oxo[1]benzothiepino[4,3‐d]oxazoles (XIXd‐XIXf) were prepared.
Reaction of the pyrazinium ion having aryl and cyano groups with hydride reagents or hydroxide ion
Authors: Hirano Hadeki , Tada Masaru 
Published: March 2009

AbstractReduction of 3‐cyano‐5‐(3,4‐dimethoxyphenyl)‐1‐methylpyrazinium ion by the hydride reagents such as sodium borohydride or Hantzsch ester gave the 1,6‐dihydropyrazine derivative, and the 1,4,5,6‐tetra‐hydropyrazine derivative on further reduction. Addition of hydroxide ion to the pyrazinium ion gave mainly a 6‐hydroxy‐pseudobase, accompanied by the minor formation of a 2‐hydroxy‐pseudobase. Photoreaction of the pseudobase mixture gave a product from the major pseudobase but thermal transformation gave another product from the minor pseudobase.
Reissert compound studies. XLII. Synthesis and reactions of the 3,4‐dihydro‐β‐carboline reissert compound and observations on α, β, and γ‐carbolines
Authors: Veeraraghavan Seshadri , Popp Frank D. 
Published: March 2009

Abstract3,4‐Dihydro‐β‐carboline and benzo[α]‐γ‐carboline yielded Reissert compounds. The 3,4‐dihydro‐β‐carboline Reissert compound, through its acid‐ and base‐promoted reactions, was found to be a very useful intermediate in the synthesis of several β‐carboline derivatives including tetracyclic compounds. Reaction of the 3,4‐dihydro‐β‐carboline Reissert compound with dichlorodicyanobenzoquinone (DDQ) resulted in the formation of l‐cyano‐β‐carboline thereby providing the first example of an oxidation of a Reissert compound with DDQ. α‐, β‐ and γ‐Carbolines failed to form Reissert compounds under a wide variety of conditions. 7‐Azaindole also failed to yield a Reissert compound.
2‐Imidazolines. V. The formation of hydroxy derivatives in the synthesis of 4,5‐diamino‐2‐imidazolines from 1,2‐diimmonium salts and amidines
Authors: Malnati Maria Luisa , Stradi Riccardo , Rivera Elisabetta 
Published: March 2009

AbstractDuring the preparation of 1‐aryl‐ and 1‐acyl‐4,5‐dipiperidino‐4,5‐dihydroimidazoles (1) from diimmonium salts (3), derivatives in which one of the piperidino groups was substituted by an hydroxy group were often isolated. The structure and the genesis of these compounds are discussed.
Synthesis of 6‐benzyl‐ and 6‐phenethyl‐2,4‐diamino‐5,6,7,8‐tetrahydropyrimido[4,5‐d]pyrimidines
Authors: Delia Thomas J. , Sami Salah M. 
Published: March 2009

AbstractThe preparation of ten aralkyl derivatives of 2,4‐diamino‐5,6,7,8‐tetrahydropyrimido[4,5‐d]pyrimidines (6) has been accomplished. The title compounds were prepared in a simple one step reaction from 2,4,6‐triaminopyrimidine (4), formaldehyde (2), and either substituted benzylamines (1a‐d) or substituted phenethylamines (1e‐j). This modified Mannich reaction has been shown to be a general method for such derivatives. Elemental analysis, 1H nmr and mass spectral data have confirmed the proposed structures. None of the compounds exhibited either antimalarial or antitrypanosomal activity.
Synthesis of pyrimidine acyclonucleosides
Authors: Abrams H. M. , Ho L. , Chu S. H. 
Published: March 2009

AbstractNucleoside analogues of uridine, 5‐bromo‐, 5‐iodo‐, and 5‐fluorouridines, thymidine and cytidine were prepared by condensing appropriately substituted 2,4‐dimethoxypyrimidines with an acyclic side chain in the form of a benzoylated halo‐ether, and subsequent removal of the protecting benzoyl group in base. The 2′‐O‐p‐tosylates of these nucleoside analogues could then be modified to 2′‐halo‐, azido‐, and amino derivatives. Many of these compounds are competitive inhibitors of uridine phosphorylase in vitro, the most active being 5‐methyl‐1‐(2′‐hydroxyethoxymethyl)uracil.
Synthesis of imidazolidin‐4‐ones and their conversion into 1,4‐benzodiazepin‐2‐ones
Authors: Hannoun M. , Žinić M. , Kolbah D. , Kajfež F. , BlaŽević N. 
Published: March 2009

Abstractα‐Haloacetanilides Ia‐e react with hexamine in ethanol giving the bisimidazolidin‐4‐one derivatives IIa‐e, which hydrolize, in acidic media into the corresponding mono‐imidazolidin‐4‐ones IIIa‐e. The compounds IIa‐d were converted into 1,4‐benzodiazepin‐2‐ones, under different conditions and in the presence of a variety of agents. The yields were between 50 and 100%.
13C‐Nmr spectra of anhydro‐3‐mercapto‐5‐pyrazinyl‐1,2,4‐triazolium hydroxides
Authors: Shutske Gregory M. , Agnew Marc N. 
Published: March 2009

AbstractThe complete assignment of the 13C‐nmr spectra of some anhydro‐3‐mercapto‐5‐pyrazinyl‐1,2,4‐triazolium hydroxides (1) is reported. For purposes of comparison the spectra of some isomeric triazole‐3‐thiones (2) are also reported. Positions C‐3 and C‐5 of the triazole ring and 2′ of the pyrazine moiety were found to be characteristic of each group of compounds.
The synthesis, configuration, and conformation of cis‐ and trans‐3‐amino‐3,4‐dihydro‐1‐hydroxy‐4‐methylcarbostyrils and other configurationally related compounds
Authors: Mccord Tommy J. , Smith Sherrel C. , Tabb David L. , Davis Alvie L. 
Published: March 2009

AbstractThe cis‐ and trans‐3‐amino‐3,4‐dihydro‐1‐hydroxy‐4‐methylcarbostyrils (Ia and Ib) were synthesized by catalytic hydrogenation of erythro‐ and threo‐α‐amino‐β‐(o‐nitrophenyl)butyric acid hydrochlorides, IIIa and IIIb, respectively, under acidic conditions. The free bases of IIIa and IIIb were catalytically hydrogenated under neutral conditions to yield the erythro‐ and threo‐α‐amino‐β‐(o‐aminophenyl)butyric acids (VIa and VIb), which were converted by acidification to their corresponding lactams, cis‐ and trans‐3‐amino‐3,4‐dihydro‐4‐methylcarbostyrils, IIa and IIb. The erythro and threo isomers of α‐amino‐β‐(o‐nitrophenyl)‐butyric acid were prepared and separated by liquid chromatography via a diastereomeric mixture of (V) of methyl α‐acetamido‐β‐(o‐nitrophenyl)butyrates. The configurations and conformational assignments of the cyclic hydroxamic acids Ia and Ib were first established by analysis of the proton nmr spectra. In turn, the configurations of the o‐nitroaromatic amino acids IIIa and IIIb were assigned as well as the other structurally related compounds (VIa, VIb, IIa and IIb) derived therefrom.
Mass spectra of 5‐fluorouracil derivatives. N‐1‐substituted sulfonyl derivatives
Authors: Marunaka Teruyoshi 
Published: March 2009

AbstractThe electron impact mass spectra of 1‐sulfonyl substituted derivatives of 5‐fluorouracil were investigated. The substituents were CH3SO2 (compound I), CH3(CH2)3SO2 (II), C6H5SO2 (III) and p‐CH3C6H4SO2 (IV).
1,2,4‐Triazines. II. A new general synthesis of 3,4‐dihydro‐1,2,4‐triazin‐5‐(2H)ones
Authors: Sanemitsu Yuzuru , Nakayama Yoskinori , Shiroshita Masao 
Published: March 2009

Abstract3,4‐Dihydro‐1,2,4‐triazin‐5‐(2H)ones were prepared by the reduction of 3‐methylthio‐1,2,4‐triazin‐5‐(2H)‐ones with sodium borohydride in dimethylformamide. The synthesis appears to be general.
Synthesis of some 1‐substituted‐3‐or‐5‐styrylpyrazoles
Authors: Deshayes Christian , Chabannet Mickel , Gelin Suzanne 
Published: March 2009

AbstractThe synthesis of the title compounds by the Wittig‐Horner reaction is described, using the 3‐or‐5‐hydroxymethylpyrazole derivatives as precursors.
Synthesis of oxetanes by photoaddition of carbonyl compounds to thiophene derivatives
Authors: Rivas C. , Pacheco D. , Vargas F. , Ascanio J. 
Published: March 2009

Abstract2,3‐Dimethyl, 3,4‐dimethyl and 2,3,5‐trimethylthiophene were synthesized and subjected to interaction with excited benzophenone. 2,3‐Dimethylthiophene affords an oxetane in good yield. These experiments were carried out in order to generalize this reaction which thus far has only been successful with 2,5‐dimethylthiophene.
Rearrangement of 2‐aminofuro[3,2‐b]pyridine‐3‐carboxylic esters
Authors: Desideri Nicoletta , Manna Fedele , Stein Maria Luisa 
Published: March 2009

AbstractEthyl 2‐aminofuro[3,2‐b]pyridine‐3‐carboxylate rearranges with sodium ethoxide in ethanol to 2‐oxo‐3‐cyano‐2,3‐dihydro[3,2‐b]furopyridine; the corresponding p‐nitrophenyl ester undergoes the same rearrangement by dilute aqueous sodium hydroxide. In the first case it was possible to isolate the labile intermediate, which was shown to be the hemiacetal of the above mentioned cyanolactone.
Photosensitized oxidation of furans. III. Comparison between photochemically and thermally generated singlet oxygen oxidation of 3‐methoxycarbonyl‐2‐methyl‐5‐phenylfuran
Authors: Graziano M. L. , Iesce M. R. , Carli B. , Scarpati R. 
Published: March 2009

AbstractThermal conversion of furan endo‐peroxide I, obtained by photosensitized oxidation of furan II, yields very similar results to those of the oxidation of the furan II by thermally generated singlet oxygen, showing that also in the latter case the endo‐peroxide I is the key intermediate. A mechanistic interpretation of the furan II‐singlet oxygen reaction is reported.
Studies on v‐triazoles. Part II. Synthesis of 9‐oxo‐1H,9H‐benzopyrano[2,3‐d]‐v‐triazoles
Authors: Buckle Derek R. , Outred D. James , Rockell Caroline J. M. 
Published: March 2009

AbstractEthyl 1‐benzyl‐5‐chloro‐v‐triazole‐4‐carboxylate (3) undergoes facile nucleophilic displacement of the halogen atom with phenoxide ion to yield aryloxytriazolecarboxylates 4 which debenzylate under hydrogenolytic conditions to N‐H triazoles 7. Saponification and cyclization with either polyphosphoric acid or phosphoric oxide in methanesulphonic acid leads to the novel 9‐oxo‐1H,9H‐benzopyrano[2,3‐d]‐v‐triazole system 9, members of which have potential as antiasthmatic agents.
Synthesis of 2,5‐disubstituted oxazoles from aldehydes and N‐(tosylmethyl)imino synthons. Application to the synthesis of pimprinine analogues
Authors: Houwing Hendrik A. , Wildeman Jurjen , Van Leusen Albert M. 
Published: March 2009

AbstractA series of N‐(tosylmethyl)imino compounds [TosCH2NC(L)A] has been applied to a new base‐induced, one‐operational synthesis of 2,5‐disubstituted oxazoles from aromatic aldehydes. For substituent A of the imino compounds, which becomes the 2‐substituent in the oxazoles, has been chosen methoxy, methyl and phenyl. The new method has been used also to synthesize seven pimprinine analogues, i.e., 5‐(‐3)indolyl)oxazoles.
Chemistry of the phenoxathiins and isosterically related heterocycles. XIX.. The crystal and molecular structure of 1‐N,N‐dimethylamino‐2,3‐diazaphenoxathiin: An interesting product isolated from the reaction of o‐mercaptophenol with 3,4,5‐trichloropyridazine in N,N‐dimethylformamide
Authors: Womack Charles H. , Turley James C. , Martin Gary E. , Kimura Michio , Simonsen Stanley H. 
Published: March 2009

AbstractThe isolation of 1‐N,N‐dimethylamino‐2,3‐diazaphenoxathiin and its molecular structure as determined by X‐ray crystallography are described. The existence of a potential non‐bonded interaction between the lone pair of electrons of the dimethylamino group nitrogen and sulfur atom are also discussed.
Application of the partitioning of energy in the mndo method to the study of the basicity of imidazole, pyrazole, oxazole, and isoxazole
Authors: Olivella Santiago , Vilarrasa Jaume 
Published: March 2009

AbstractThe technique of energy partitioning of Fischer and Kollmar has been extended to the MNDO SCF‐MO method and used in an effort to ascertain the main factors which determine the greater basicity of imidazole and oxazole relative to pyrazole and isoxazole, respectively. The importance of the different degree of destabilization of the five‐membered ring π bonding in these azoles upon protonation is specially emphasized in relation to their relative basicity. Furthermore, it is found that the degree of destabilization of the π bonding can be ascribed to the amount of π electron charge density localized on the heteroatoms after protonation. An interpretation for this result is given in terms of the mutual electrostatic field effect due to the cores of the nearest‐neighbor atoms.
Some reactions of 4‐[(2′,3′‐diphenyl‐6′‐methoxy‐5′‐benzofuranyl)‐methylene]‐ and 4‐[(2′,3′‐diphenyl‐5′‐methoxy‐6′‐benzofuranyl)‐methylene]‐2‐phenyloxazolin‐5‐one
Authors: Hishmat O. H. , Abd El Rahman A. H. , Moawad M. I. 
Published: March 2009

Abstract2,3‐Diphenyl‐5‐formyl‐6‐methoxybenzofuran was reacted with hippuric acid to give 4‐[(2′,3′‐diphenyl‐6′‐methoxy‐5′‐benzofuranyl)methylene]‐2‐phenyloxazolin‐5‐one. The above mentioned oxazolone yielded 2,3‐diphenyl‐6‐methoxybenzofuranylacetic acid by reaction with hydrazine hydrate, nitrous acid, benzene followed by acid hydrolysis. The reactions of the oxazolone with hydroxylamine hydrochloride and primary or secondary amines were also investigated.
Nucleophilic substitution at sulphonyl sulphur part 3. Hydrolysis of substituted thiophene‐2‐sulphonyl chlorides catalysed by silver nitrate and silver nitrite salts
Authors: Ballistreri Francesco P. , Tomaselli Gaetano A. 
Published: March 2009

AbstractHydrolysis reactions of substituted thiophene‐2‐sulphonyl chlorides (5‐methyl, 5‐H, 5‐chloro, 5‐nitro) catalysed by silver nitrate and silver nitrite salts have been studied in water at 25°. Salt effects by potassium nitrate, sodium perchlorate and mercuric bromide have also been investigated. For the catalysis effected with silver nitrate, the pseudo‐first order rate constants depend on the first power of silver ion concentration, while nitrate anion is not involved in the transition state. The corresponding curved Hammett plot suggests a transition state with a partially developed sulphonylium character. With silver nitrite, the rate dependence on both silver and nitrite ion concentrations would indicate that silver is involved in the transition state as well as nitrite. Also, in this case the curved Hammett plot obtained suggests a partial positive charge on the sulphur atom in the transition state. A comparison with uncatalysed hydrolysis reactions would support a previous interpretation that thiophene‐2‐sulphonyl chlorides hydrolyze by an SN2 type mechanism which can shift toward an SN1 or an SAN process depending on the ring substituent.
Indolo[1,7‐ab][1]benzazepine, a new 18 π‐electron heterocycle
Authors: Hallberg A. , Martin A. R. 
Published: March 2009

AbstractThe synthesis of indolo[1,7‐ab][1]benzazepine was accomplished by cyclization of 5H‐dibenz[b,f]azepine‐5‐acetaldehyde.
The vilsmeier‐haack formylation of 1,2,3‐trimethylindole
Authors: Bastianelli Carlo , Cipiciani Antonio , Clementi Sergio , Giulietti Gianfranco 
Published: March 2009

AbstractThe title reaction yields mainly a side‐chain monosubstituted formyl derivative, namely 2‐(1,3‐dimethylindolyl)acetaldehyde.
Some new phenolic pyrazoles from 2′‐Hydroxychalcones
Authors: Oluwadiya J. O. 
Published: March 2009

Abstract2′Hydroxychalcones react with hydrazine hydrate in water to form phenolic 4,5‐dihydro‐3,5‐diphenyl‐1H‐pyrazoles. Condensation of the pyrazoles with toluenesulphonylchloride in pyridine gave 4,5‐dihydro‐3,5‐diphenyl‐1‐toluenesulphonylpyrazoles.
5‐Imino‐Δ3‐1,2,4‐thiadiazoline derivatives with a linear N‐S…O grouping. Synthesis and crystal structures
Authors: L'abbé Gerrit , Vermeulen Guido , Toppet Suzanne , King Geoffrey S. D. , Aerts Jozef , Sengier Lieve 
Published: March 2009

AbstractA series of carbonyl derivatives of 5‐imino‐Δ3‐1,2,4‐thiadiazolines has been prepared and shown by X‐ray analysis of a selected example to have a trithiapentalene‐like structure. When diphenylketene was used as acylating reagent, the primary product (14), obtained at room temperature, rearranged on heating in a polar solvent into a Δ2‐thiazolin‐4‐one (15). The structure of 15 has been confirmed by X‐ray analysis, and shown to be a zwitterion. Rearranged products (i.e., 16 and 20‐22) were also obtained when 3 was reacted with dimethyl acetylenedicarboxylate or methanesulfonyl chloride, whereas tosyl chloride gave normal tosylated derivatives (17‐19). The latter have also a nearly linear N‐S…O arrangement, but the interaction between S and O is weak.
Further studies on the reaction of N‐(2‐Hydroxyphenyl)anthranilic acids with acetic anhydride
Authors: Kim Dong Han 
Published: March 2009

AbstractReaction of N‐(2‐hydroxyphenyi)anthranilic acids (I) with acetic anhydride was investigated further. Treatment of Ia with refluxing acetic anhydride for 3 hours afforded two minor products, IIIa and IV, in addition to the previously reported IIa. Under similar conditions, the reaction of Ib with acetic anhydride afforded IIb as reported previously, and IIIb and IXb in small quantities. Treatment of IIIb with hydrazine gave X, and treatment of IXb with methoxyethylamine gave XI. When Ic was allowed to react with refluxing acetic anhydride, there were obtained three minor products, IIIc, IXc and XIII, in addition to IIc. Reaction of Id with acetic anhydride gave IId, and two minor products IXc and XIV. The formation of these minor products in the reaction of Ia‐d with acetic anhydride are discussed based on the reation mechanism proposed previously for the formation of II.
The chemistry of 5H‐benzoxazolo[3,2‐a]quinolin‐5‐ones. 5H‐Benzoxazolo[3,2‐a]quinolin‐5‐ones as synthons for the preparation of novel quinoline derivatives
Authors: Kim Dong Han 
Published: March 2009

AbstractThe usefulness of 5H‐benzoxazolo[3,2‐a]quinolin‐5‐ones (I) as synthons for the preparation of otherwise difficulty obtainable quinolin‐5‐ones is demonstrated. Nucleophilic reagents cleaved the oxazole ring of I at the 7‐position, resulting in 1‐(2‐hydroxyphenyl)‐2‐substituted 4‐(1H)quinolinones. Treatment of 5H‐benzoxazolo‐[3,2‐a]quinolin‐5‐one (Ia) with ethanoiic potassium hydroxide gave 1‐(2‐hydroxyphenyl)‐2‐ethoxy‐4‐(1H)quinolinone (IIIa), and attempted formylation of Ia with the Vilsmeier‐Haak reagent instead gave 2‐chloro‐1‐(2‐hydroxyphenyl)‐4‐(1H)quinolinone (II). Likewise, 10‐chloro‐5H‐benzoxazolo[3,2‐a]quinolin‐5‐ones (Ib) afforded 2‐ethoxy‐ and 2‐methoxy‐1‐(5‐chloro‐2‐hydroxyphenyl)‐4‐(1H)quinolinone (IIIb and IIId) upon treatment with ethanol and methanol, respectively. Reaction of Ib with 1‐phenylpiperazine yielded 1‐(5‐chloro‐2‐hydroxyphenyl)‐2‐(4‐phenyl‐1‐piperazinyl)‐4‐(1H)quinolinone (IV). Alkaline hydrolysis of IIIb gave 1‐(2‐hydroxy‐5‐chlorophenyl)‐2‐(1H)quinolinone (V). Treatment of IIId with epichlorohvdrin gave 1‐[5‐chloro‐2‐(2‐oxiranylmethoxy)phenyl]‐2‐methoxy‐4‐(1H)quinolinone (VIa) which in turn upon treatment with isopropylamine gave 1‐[5‐chloro‐2‐[2‐hydroxy‐3‐(1‐methylethylamino)propoxy]phenyl]‐2‐methoxy‐4‐(1H)quinolinone (VIIa). Similarly, the ethoxy analog (VIIb) was prepared. Reaction of Ib with sodium cyanide in dimethylsulfoxide produced 1‐(5‐chloro‐2‐hydroxyphenyl)‐1,4‐dihydro‐4‐oxo‐2‐quinolinecarbonitrile (X) which was hydrolized to give the corresponding carboxamide (XIV) and carboxylic acid (XI) depending on the reaction conditions. The latter yielded 2‐chloroquino[2,1‐c][1,4]benzoxazine‐6,8‐dione (XII) when heated with an excess of acetic anhydride. Treatment of XII with methoxyethylamine gave 1‐(5‐chloro‐2‐hydroyphenyl)‐1,4‐dihydro‐N‐2(methoxyethyl)‐4‐oxo‐2‐quinolinecarboxamide (XV). 1‐(5‐chloro‐2‐hydroxyphenyl)‐2‐(1H‐tetrazoyl‐5‐y1)‐4‐(1H)qutnolinone (XIII) was prepared from X. When Ib was allowed to react with sodium diethylmalonate, there was obtained [1‐(5‐chloro‐2‐hydroxyphenyl)‐1,4‐dihydro‐4‐oxo‐2‐quinolinyl]‐propanedioic acid diethyl ester (XVI) which was transformed to 1‐(5‐chloro‐2‐hydroxyphenyl)‐1,4‐dihydro‐4‐oxo‐2‐quinolinacetic acid ethyl ester (XVII) upon heating in hexamethylphosphoramide.
Dipolar additions with 1‐(4,6‐dimethylpyrimidin‐2‐yl)‐ and 1‐(4,6‐dimethoxy‐s‐triazin‐2‐yl)‐3‐oxidopyridinium betaines
Authors: Moustafa A. Heshmat , El‐Abbady Samia A. , Jones R. Alan 
Published: March 2009

AbstractCycloaddition to 1‐(4,6‐dimethylpyrimidin‐2‐yl)‐ and 1‐(4,6‐dimethoxy‐s‐triazin‐2‐yl)‐3‐oxidopyridinium betaines across the 2,6‐positions of the pyridine rings with indene, acenaphthylene and ethyl cinnamate gave substituted 8‐aza[3.2.1]bicycIooct‐3‐en‐2‐ones, whereas the [6π + 4π] cycloaddition reaction with 6,6‐dimethylfulvene gave a tricyclo[6.3.1.02.6]dodeca‐2,(6),4,9‐trien‐11‐one. Structural and configurational assignments of the cycloadducts were deduced from 1H nmr and ir spectral data.
Ring opening reaction of 3,6‐Dihydro‐2‐(1H)pyrimidinones with hydroxylamine hydrochloride
Authors: Kashima Choji , Katoh Akira , Yokota Yuko , Omote Yoshimari 
Published: March 2009

Abstract1,4,6‐Trisubstituted 3,6‐dihydro‐2‐(1H)pyrimidinones (Ia‐d) easily underwent the ring opening reaction with hydroxylamine hydrochloride to afford the oximes (IIa‐d) in good yields. In the case of 3,6‐dihydro‐6‐methyl‐I‐phenyl‐2‐(1H)pyrimidinone (Ie), 2‐anilinobutyronitrile (III) was obtained in addition to the oxime (IIe). Dihydro‐2‐(1H)pyrimidinone (IV) and ‐thiones (V and VI) did not undergo the ring opening reaction.
Synthesis and structural study of quinuclidine spiro derivatives
Authors: Trigo G. G. , Martinez M. , Galvez E. , Cabezas R. 
Published: March 2009

AbstractThe synthesis of quinuclidine‐3‐spiro‐5′‐oxazolidine‐2′,4′‐dione, quinuclidine‐3‐spiro‐5′‐hydantoin, and some 3′‐derivatives is described. Based on the data from 1H and 13C‐nmr spectra the structure of the above mentioned compounds is established. A relationship between second order effects in 13C‐nmr spectra and H‐C‐C‐H dihedral angles is deduced.
Kinetics and Mechanism of the Isomerisation of 2,4,6‐Triphenyl‐4H‐Thiopyran
Authors: Abdallah Abdallah Abd El‐Azeem , El Nahas Hind Mostafa 
Published: March 2009

AbstractIsomerisation of 2,4,6‐triphenyl‐4H‐thiopyran into 2,4,6‐triphenyl‐2H‐thiopyran has been studied kinetically and the rate of the reaction was determined in dimethylformamide. The first order rate constant could be expressed in terms of the Arrhenius parameters by the equation kt = 2.85 × 107 e−15820±110/RT.