bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neue Befunde zur Diagnose und Klinik der chronischen Aminoacidurie mit Cystinspeicherung1
Authors: WEYERS HELMUT 
Published: January 2008

Zusammenfassung

An Hand einer neuen Beobachtung von chronischer Aminoaci‐durie mit Cystinspeioherung, welche in typischer Weise ein blondhaariges I‐jahriges Madchen blutsverwandter Eltern betrifft, werden neue dia‐gnostische und klinische Befunde d'ieser seltenen Erkrankung zusam‐mengestellt.
Neben der alteren Methode des Cystinkristallnachweises im Sternal‐markausstrich vermag eine technisch einfache Darstellung des kristal‐linischen Cystins in der Augenbindehaut die Verdachtsdiagnose schnell zu sichern. Kristallographische Differenzierungen erlauben hierbei grund‐sätzlich 2 Kristallformationen zu unterscheiden, die durch Eigentüm‐lichkeiten der Lichtbrechung voneinander abweichen.
Chromatographische Aminosäurenbestimmungen werden mikro‐biologisch ermittelten AS‐Konzentrationen des Urins und den bislang wenig bekannten Serumwerten gegenübergestellt. Dabei lässt sich feststellen, dass neben wechselnden Konzentrationen anderer Aminosäuren weder im Serum noch im Urin eine Cystinvermehrung vorhanden ist.
Die Speicherung des schwerlöslichen Cystins im Retikulo‐endothelialen System kann durch den Nachweis von Verschiebungen der Serum‐eiweisskörper nach elektrophoretischer Bestimmung bekräftigt werden.
Bezüglich der Glykolabilität dieser Erkrankung werden neue mit dem Zuckerhaushalt gekoppelte Verschiebungen der Kaliumbilanz angeführt. Die Glukosenatur der, durch Anhäufung S‐haltiger Verbindungen im Blute der an Cystinose erkrankten Kinder, erklärbaren Ausscheidung reduzierender Substanzen wird durch chromatographische Differenzierungen sichergestellt.
Mit den kurz erwähnten pathogenetisch nahestehenden Zustands‐bildern wird vor allem eine Verwandtschaft der Aminoacidurie vom Cystinosetyp mit der Coeliakie hervorgehoben und auf die Differenzial‐diagnose eingegangen.
Investigations into the Pyruvic Acid Concentration in Blood from Children with Convulsive Fits and Petit Maf and an Assessment of the Significance of Muscular Activity on Pyruvic Acid Estimations in Infants in General
Authors: LOODlNG CATO 
Published: January 2008

SummaryThe pyruvic acid concentration was estimated in blood from 20 children between the ages of 2 months and 13 years suffering from convulsive fits or petit mal. 25 patients between the ages of 6 weeks and 14 years with no tendency to convulsive fits or petit mal served as controls. A mean value of 1.43 mg per cent was found in the convulsive‐petit mal group (extremes 0.86 and 2.08 mg per cent), while in the control group the mean value was 1.30 mg per cent (extremes 0.83 and 2.07).In the patients over 5 years of age, who generally kept quiet during the sampling, normal mean values were found both in the convulsive‐petit mal group and the control group. Those under 5 years of age, who never were at rest during the sampling, presented abnormally high mean values in both groups. The high pyruvic acid values are probably attributable to the great muscular activity displayed by these infants during the venepuncture. Experiments were made which showed that in children even light muscular work produces a rather considerable rise in the pyruvic acid concentration in blood. The conclusion is drawn that no significant difference is found between children with convulsive fits or petit mal and a control series with regard to the pyruvic acid concentration in blood.
The Effect of Universal Carbon‐Arc light Therapy on the Development of Immunity
Authors: HEINILD SV. , EDWARDS P. Q. , FDQHT‐NIELSEN K. ‐E. , HANSEN K. G. , MAGNUS K. , SCHEIBEL I. 
Published: January 2008

SummaryA firm biological foundation for the beneficial effect of carbon‐arc light treatment is still lacking. Based on the assumption of a protective effect against infection, the investigations reported in this paper concern the production of antibodies in children during treatment with universal carbon‐arc light. Parallel control groups, treated with light of an indifferent ultraviolet content or with no light at all, were used in the studies. The formation of tetanus antitoxin after immunization with the usual doses of tetanus prophylactic could not be shown to be influenced by carbon‐arc light treatment. Neither was it possible to influence the tuberculin sensitivity of naturally positive persons, nor the development of local lesions and tuberculin allergy after vaccination with BCG. Attention is drawn to investigations concerning the neuro‐muscular system, physical capacity, and metabolic variations, as possibly being fruitful spheres for continued study, and strong emphasis is laid on the absolute necessity of accurate dosimetry in future scientific investigations concerning the biological effect of light.
Cortisone Treatment of Skin Involvement, Acrodermatitis Enteropathica, in a Case of Cystic Fibrosis of the Pancreas
Authors: UGLAND JENS 
Published: January 2008

SummaryA case is reported of a child with fibrosis of the pancreas presenting a picture which resembled that earlier described in the disease designated acrodermatitis enteropathica and the possibility is suggested that this latter disease is always due to pancreatic fibrosis. The previously reported cases seem to support this assumption. The patient was treated with cortisone with very good effect. A preliminary account of the use of cortisone therapy for celiac disease is also given. The results noted appear to be encouraging.
Iodine and Sporadic Goiter in Childhood
Authors: HERLITZ GILLIS 
Published: January 2008

SummaryJudging from the effects of treatment with iodine, reasons are given for the opinion that endemic and sporadic simple goiter in childhood may have different causes. Two pairs of identical twins with simple goiter of the sporadic type were followed for some years, one of each pair receiving intensive treatment with iodine and the other being left untreated. In neither of the cases could any effect of iodine be demonstrated. An increased demand for iodine in the food was obviously not the cause of the thyroid enlargement in these cases. Various possibilities regarding pathogenesis are discussed. The author is of the opinion that a reduced production of thyrotropic hormone by the anterior pituitary may be responsible for at least some cases of sporadic goiter just before and during puberty. The resulting compensatory enlargement of the thyroid in these cases is not the result of nutritional deficiency and consequently does not respond to the usual treatment with iodine.
Familial Early Infantile Myasthenia Gravis
Authors: BORNSTEIN B. 
Published: January 2008

SummaryA report is given of two cases mdash; two children of a healthy mother mdash; who acquired myasthenia. The disease appeared in both cases, in the third month of their life. At the age of five and seven years respectively, typical symptoms were present, affecting the eyelid, face and chewing muscles. Prostigmin improved the symptoms.
Pattern of Children's Disease and Death as Seen in a Children's Hospital, Colombo, Ceylon
Authors: SILVA C. DE , SOYSA PRIYANI 
Published: January 2008

Summary and ConclusionsIntestinal parasitism was the chief cause of ill health in children in hospital. Ascaris lumbricoides was the commonest intestinal parasite and the Trichuris trichiura was the second. The incidence of intestinal parasitism rose with each year of life and was extremely high at 5 years and over.Nutritional disorders were common including many cases of fatty liver and oedema as well as of Vitamin A and riboflavin deficiences. A pre‐Bitot pigmentation which was often the precursor of a Bitot and a “gutter” pigmentation of the lower part of the sclera are described. The former was a vitamin A deficiency and the latter was probably due to combined vitamin A and riboflavin deficiencies.Among the respiratory diseases bronchopneumonia caused a high fatality rate in the age group below 5 years.Gastro‐intestinal disorders showed a peak in incidence during the first year of life, the fatality rate was high also in following years. Salmonellosis was a common cause of diarrhoeas in infancy and early childhood.The vast array of preventable diseases is heartrending. All possible forces and resources of the country should be marshalled and put into action in order to reduce the unnecessary suffering and sorrow caused to children by poverty, superstition, ignorance, wrong food habits and pernicious teaching by those who should know better.
Asthmatic Bronchitis in Children Prognosis for 162 cases, observed 6–11 years
Authors: BOESEN IB 
Published: January 2008

SummaryOne hundred and eighty five children with asthmatic bronchitis admitted to hospital during 1940–1945, were reviewed with an extensive questionaire in 1951, to see if asthma bronchiale had subsequently developed. One hundred and sixty six replies were received. The prognosis for asthmatic bronchitis as a result of an infection of the respiratory organs (e.g. pneumonia with prolonged expiration), is better than the prognosis for “pure” asthmatic bronchitis, and the prognosis is the same for both sexes. The older the child the more serious is the prognosis, especially among the allergically disposed; it is also worse among the nonallergically disposed than among children who have never had asthmatic bronchitis. It is not of any prognostic importance if the asthmatic bronchitis is associated with a temperature = 38°C on admission or not.
Further Studies of Tuberculin Hemagglutination in Tuberculous Infection, Benign and Virulent1
Authors: LAGERCRANTZ R. , PETERSON J. C. , LIND J. 
Published: January 2008

SummaryAdditional data on the tuberculin hemagglutination test in various types of tuberculous infection have been presented. The reproducibility of the test has been examined by running duplicates at different times. BCG vaccination in the neo‐natal period evokes a agglutinin response only after a relatively long period of time, whether or not the child has additional exposure to tuberculosis. Infants having such exposure develop higher titers, without having clinical evidence of any superinfection. Re vaccination with BCG evokes an anamnestic type of antibody response. The anamnestic response is not activated sufficiently or promptly enough by tuberculin testing to affect hemagglutinin studies within 2 weeks after the first tuberculin test. – 163
On Plasma Calcium in Cord Blood and in the Newborn A Preliminary Report
Authors: HALLMAN NIILO , SALMI IRJA 
Published: January 2008

SummaryA study is made of calcium contents in arterial and venous cord blood, the plasma calcium of the newborn (aged 1 to 3 days) and of the mother in 15 cases. The blood entering the infant from the afterbirth invariably contains more (0.3–2.3 mg/100 ml) calcium than the blood brought back from the infant. The calcium contents of the blood entering the placenta and of the infant's blood after birth are approximately on the same level, and the values are frequently higher than for the calcium of the mother. The findings of earlier investigators that the elevation of the cord calcium is high as compared to calcium of the infant, is mainly due to the circumstance that no separate consideration has been given to umbilical artery and umbilical vein.
On Psychogenic Obesity in Children II1
Authors: JUEL‐NIELSEN NIELS 
Published: January 2008

SummaryIn the light of BRUCH'S works and theory, psychogenic aspects of childhood obesity have been estimated on the basis of a re‐examination of 61 obese children. An account is given of the material and the methods of investigation.It has not been possible to prove a characteristic outward social, family, and psychological constellation of surroundings for obese children. Recurrent characteristics in the surroundings are frequent occurrences of obesity in the families, great eating‐habits, and a wide‐spread tolerance of these phenomena. Most cases have confirmed that obese children have an abnormally great food intake, often combined with bodily inactivity. In their attitude to the fat child and in their views on such subjects as health, illness, eating‐habits, and obesity, a great percentage of the mothers have displayed many points of resemblance and common characteristics, which are interpreted as extreme and abnormally exaggerated expressions of traits that presumably were universal and typical of the Danish population of a certain period. Nothing has been found that can justify the assumption of a recurrent ambivalent attitude with secondary overprotection on the side of the mothers. By a direct diagnostic estimation of each separate obesity case in the material 9 cases were nominated ‘positive’. 12 ‘doubtful’, 40 ‘negative’ with regard to psychogenic obesity. The criteria for this division are discussed, and a few typical case histories are presented in condensed versions.Finally, attention is called to the desirability of procuring comparable control materials.
A Hyperacute Case of Erythroleukaemia Treated with Aminopterin
Authors: LIEN‐KENG KHO 
Published: January 2008

SummaryDescription of a case of erythroleukaemia (morbus Di Guglielmo) in an infant of 7 months of age, where the symptoms manifested themselves shortly after smallpox vaccination. The patient had high fever, marked hepato‐splenomegaly, anemia and thrombocytopenia as well as leucocytosis, with the occurrence of young, often atypical myeloid and erythroid elements in the blood. The erythroid elements dominated over the myeloid elements in the marrow. The treatment, consisting of aminopterin, supported by blood transfusions and antibiotics, did not influence the acute fatal development, although the young myeloid elements (myeloblasts, promyelocytes, and myelocytes) soon disappeared from the blood, and the liver and spleen grew smaller. At autopsy, erythroid and myeloid proliferation were found in the marrow, liver, spleen, lymphnodes, thymus and intestines.
Herpes Simplex A Study of Complement‐Fixing Antibodies at Different Ages
Authors: HOLZEL A. , FELDMAN G. V. , TOBIN J. O'H. , HARPER J. 
Published: January 2008

Summary1. A study of antibodies to herpes simplex virus in different age groups has been made, using the complement fixation technique. Antigen derived from the chorioal‐lantois of the chick embryo is evaluated.
Aetiological Studies on Infantile Diarrhoea in Finland
Authors: RANTASALO ILARI , HALLMAN NIILO 
Published: January 2008

SummaryResults have been given of the occurrence of Salmonellas, Shigellas and Escherichia coli types 0–111, 0–55, 0–44, and 0–26 in the excrements of infants belonging to a series from a Finnish hospital for children. The under‐groups of E. coli are not studied.During the first period in the course of which 259 infants were under treatment (33 of them over one year old) only bacteria of the Salmonella and Shigella groups were studied. They were found in about 5 % of the cases. Two of them were Salmonella paratyphi B and the remainder Shigella Sonnei. These micro‐organisms were considerably more abundant in the older children. During the second period which immediately followed the first a study of 270 infants was made who were all under one year of age. Salmonella paratyphi B was demonstrated once and Salmonella typhi murium twice. Bacilli of the Shigella group were not found.In this group of infants the Escherichia coli type 0–111 was found in 14 patients type 0–55 in 2, type 0–44 in 16, and type 0–26 in 29 patients. E. coli strains 0–111 and 0–26 were found for the most in s.c. toxic diarrhoeas. In the milder forms and particularly in cases simultaneously suffering from a respiratory infection, a positive finding was less frequent. E. coli type 0–111 was recovered from 6 of 8 patients who had fallen ill with diarrhoea at the same orphanage. This strain was more often present in patients transferred for treatment from the various child welfare institutions, although no noteworthy epidemic of diarrhoea had occurred at any of them. The remainder were individual cases scattered all over the country. The Escherichia coli types studied were most often present in infants 3 to 6 months old and least often in infants over 6 months of age. The seasons of the year did not affect the occurrence of these strains in any particular way.The control series embracing 68 completely healthy children yielded one case of E. coli type 0–44. It was also found in 5 infants recovering from diarrhoea, at a later stage, although the stool specimens had been negative on admission.On the basis of the results it seems probable that Escherichia coli types 0–111 and 0–26 are to some extent significant in the aetiology of infantile diarrhoea. E. coli type 0–55 was so infrequent in this series that no conclusions are justified with regard to it.
Use of Hyaluronidase in Scleroderma
Authors: CLAESSON ULLA , LINDQUIST BERTIL 
Published: January 2008

SummaryOne case of generalized progressive scleroderma in a 10 year old girl is described. ACTH and para‐amino‐benzoic acid had no or contrary effect, while hyaluronidase showed a good effect on the skin lesions as well as on the tissue indurations.
Tuberculin‐Sensitivity and Antibodies (Agglutinins) after BC G‐Vaccination1
Authors: LAGERCRANTZ R. , ENELL H. 
Published: January 2008

Summary1. Twohundred and fortyeight healthy school‐children, who had been BCG‐vaccinated 3 months to 5 years previously were tuberculin‐tested and blood‐samples were drawn for hemagglutination‐tests. (MIDDLEBROOK‐DUBOS.)2. All except 6.1 % were tuberculin‐positive and there was only an insignificant fall of tuberculin‐sensitivity in the groups vaccinated 3–5 years earlier.3. Sixtyfive % of the children had a hemagglutination‐titer of at least 1/8. The titers of the children vaccinated 3 months previously were significantly higher than the titers of the children, who had been vaccinated earlier.4. There was no correlation between high tuberculin‐sensitivity and an elevated titer, nor between a newly increased sensitivity and a higher titer.
Further Studies on Hemagglutination‐Tests in Primary, Secondary and Tertiary Tuberculosis1
Authors: LAGERCRANTZ R. , WOLFROM I. 
Published: January 2008

Summary1. Out of 63 cases of primary tuberculosis 72 % showed a titer‐value of at least 1/8, using MIDDLEBROOK‐DUBOS' technique, compared with 78 % out of 83 cases of secondary and 84 % out of 144 cases of tertiary tuberculosis.2. There is no certain correlation between the clinical picture and the titer‐values except that all cases of severe meningitis with bad general state of health have shown no increase, and these cases had a bad prognosis.
Reticuloendotheliosis maligna
Authors: ESKELUND G. M. C. 
Published: January 2008

ZusammenfassungNach einer kurzen Einführung in die lieutige Problemstellung in der Auffassung der drei Retikulosen: Mb. Hand‐Schüller‐Christian, Mb. Letterer‐Siwe und des eosino‐philen Granuloms, berichtet man iiber einen eigenen Fall. Dieser ist als ein Übergangs‐fall, zwischen Hand‐Schüller‐Christian und Letterer‐Siwe stehend, anzusehen. Man ventiliert die Möglichkeit einer biologisclien Progression, ausgehend primür von einem eosinophilen Granulom.
Active Basal Immunity and Its Application to Epidemiology IV. Initial Pain in Diphtheria‐Tetanus‐Pertussis Vaccination
Authors: HESSELVIK LENNART , ERICSSON HANS 
Published: January 2008

SummaryThe addition of a quick‐acting local anaesthetic (xylocain, Astra) to aluminum‐precipitated diphtheria and tetanus toxoid and to triple vaccine (diphtheria‐tetanus‐pertussis) was tested in human subjects. A considerable reduction of the initial pain following the injection was noted. No diminution of the immunizing effect was observed in animal experiments.
Penicillin Treatment of Scarlet Fever1
Authors: STRÖM JUSTUS 
Published: January 2008

SummaryFrom various test series during the years 1946–51 consisting of 6,500 cases of scarlatina it appears that penicillin has an excellent effect in preventing complications. Not only in comparison with normally hospitalized patients, but also with entirely isolated patients, there is a clear difference in favor of treated cases. It is also shown that the peroral therapy given was, in spite of the low dosage, very little inferior to injection from the point of view of complications. The effect in preventing complications applied particularly to the bacterial types. A difference is also apparent, however, in regard to toxic types. The only complication of this kind which proved of any significance during the years of the tests was myocarditis. According to Levander‐Lindgren's investigations of the material the frequency of myocarditis also diminished as a result of penicillin treatment. This is of particular importance in patients over 15 years, in whom myocarditis is of a more serious character.
Di Guglielmo's Disease Comments on a Case of Erythroleucemic Myelosis
Authors: HEDENSTRÖM GRETA , SÖDERSTRÖMsp> NILS 
Published: January 2008

SummaryA disease is described in a girl aged 14 years, in which an acute myeloblasts leu‐cemia was combined with a probably analogous affection of the erythropoietic system. There were definitely leucemic myeloblast counts in the blood, but there, as well as in the bone marrow, the myeloblasts were outnumbered by mostly very immature erythroblasts, many of which were atypical. A hyperchromic anemia and signs of hemorrhagic diathesis were present. The clinical course of the disease was that of a very acute leucemia and the patient died after three weeks' observation. It is considered to be a case of genuine erythroleucemic myelosis (erythroleucemia).
Endocardial Fibroejastosis in Infancy
Authors: OLEMORTENSEN  , KISSMEYER‐NIELSEN F. , KØLLE‐JØRGENSEN P. 
Published: January 2008

SummaryEndocardial fibroelastosis was formerly interpreted as a fetal endocarditis, but has later been described under many different names. The etiology is obscure, but the disease is now believed to be a developmental defect. There is an increase in the fibroelastic tissue of the endocardium, usually located in the left side of the heart. Considerable enlargement of the heart is most frequently present, and other concurrent cardiac malformations are not uncommon. The disease is one of infancy. As the diagnosis can be established with certainty only by autopsy, the mortality figures are unknown. In most cases reported in the literature the duration of the disease has been short. The most important clinical signs are cardiac enlargement, dyspnea, cyanosis, atypical murmurs, and dyspepsia. Three cases with typical histological changes are reported.
Studies on Lipids, Proteins and Lipoproteins in Serum from Newborn Infants
Authors: RAFSTEDT STURE , SWAHN BENGT 
Published: January 2008

SummaryWith new micromethods it has been possible to determine in 0.6 ml serum the concentration of total and free cholesterol, phospholipids, and total lipids, and to perform electrophoretic separation of the protein fractions as well as of the various lipid fractions. Sera from blood of the umbilical cord and from capillary blood from 50 infants 1–6 days old were analysed. The cholesterol, the total lipids and the phospholipids increased 70–80 per cent during the first few days of life. The marked increase in the lipids in the serum after birth was ascribable above all to the striking increase in the β‐fraction, but also to the lipids in the fraction termed “chylomicrons”. The α1‐fraction showed a moderate but statistically significant increase. During the first few days of life the α‐ and β‐globulins showed a statistically significant increase while the γ‐globulin showed a statistically significant decrease. The albumin fraction did not change significantly.
On Tuberculosis of the Bones and Joints of BCG Vaccinated Children
Authors: BACKMAN ALF , WALLGREN ERIC IVAR 
Published: January 2008

SummaryNo harmful effect of BCG vaccination has been found in the present group of 17 cases of bone and joint tuberculosis occurring in adequately vaccinated subjects. In these cases the disease has taken a mild course; however, the number is too small to permit of any definite conclusions. In only 2 of the cases a strong exposure had occurred, in the others only a slight one, or exposure was not detected.