bluuebunny/crossref_metadata_2025_split huggingface dataset:
III National Annual Scientific-Ecclesiastical Conference «Justinian’s Readings»
Authors: Задорнов Александр 
Published: April 2024

27–28 ноября 2022 года кафедра церковно-практических дисциплин Московской духовной академии провела III Всероссийскую ежегодную научно-практическую конференцию «Юстиниановские чтения», посвященную вопросам канонического права и литургики.
On 27-28 November 2022, the Department of Church-Practical Disciplines of the Moscow Theological Academy held the III All-Russian Annual Scientific and Practical Conference "Justinian's Readings" devoted to the issues of canon law and liturgics.
Morphological and clinical findings in placentas and newborns with a history of tobacco, alcohol, and other substance abuse during pregnancy
Authors: Mendez-Reyes H.F. , Franco-Olaya M. , Canon-Cubillos O. , Uribe-Lopez J.M. , Delgado-Alvarez M.C. , Velasquez-Portilla M. , Olaya-C M. 
Published: April 2024

BACKGROUND: Exposure to toxins during pregnancy is the main modifiable behavior that affects the placenta and, consequently, the fetus. In particular, smoking is a recognized risk factor for negative outcomes. Our study pretended to examine gross and microscopic placental features in women who reported exposure to tobacco, alcohol, or other psychoactive substances. METHODS: In this observational case-control study, we collected 706 placentas to assess precise substance exposure histological-interaction features of in the placenta. We examined gross and microscopic placental features, and then recorded maternal and newborn clinical conditions. RESULTS: We found that 4.8% of mothers admitted to consumption of some type of (harmful) substance. The most common pre-existing maternal condition was obesity (20.3%); predominant complications included amniotic infection (32.3%), urinary tract infection (14.5%) and hypertensive disorders of pregnancy (14.5%). In newborns, we discovered positive associations as respiratory distress syndrome. Macroscopically, exposed mothers had heavier placentas, more true knots, and single umbilical artery; microscopically, they were more likely to exhibit fetal vascular malperfusion (FVM). CONCLUSIONS: Until our present study, no research linked umbilical cord defects to toxic substance exposure; our study results do confirm association with adverse outcomes in neonates and alterations in the neuro-cardio-placental circuit through FVM. IMPLICATIONS: The results are confirming the importance of this modifiable risk factor and how its presence may potentially affect the course of pregnancy, as well as the health of both mother and child.
A rare case of methemoglobinemia in a preterm newborn with unclear etiology
Authors: Abu Zahra M. , Jaber Dunia Z. , Badran Eman F. 
Published: April 2024

Cyanosis is a bluish discoloration of the tissues due to increased levels of deoxygenated hemoglobin in capillaries. It is a common finding in newborn infants that can be caused by different diseases, including pulmonary, cardiac, infectious, and hematological disorders. Methemoglobinemia is a rare cause of cyanosis, in which hemoglobin is oxidized, changing its heme iron configuration from the ferrous (Fe2 +) to the ferric (Fe3 +) state, creating methemoglobin (Met-Hb), a form that does not bind oxygen, leading to decreased oxygen delivery to the tissues and cyanosis. We report a rare case of a preterm newborn, who developed cyanosis and worsening hypoxemia on day ten of life, she was found to have elevated Met-Hb percentage in blood gas analysis that required treatment with intravenous methylene blue. Her symptoms resolved after a period of maintenance treatment with oral methylene blue and ascorbic acid, and the etiology of her disease remains unclear.
Shaping the Public Space Discourse with the Global South
Authors: Bravo Luisa 
Published: April 2024

When I presented The Journal of Public Space at Habitat III, the United Nations Conference on Housing and Sustainable Urban Development, in Quito (2016), during an event at the Urban Library, I made it very clear that the partnership that City Space Architecture had established with UN-Habitat inspired our mission to give voice to unheard countries in order to include them in the discourse on public space. At the beginning of 2022 The Journal of Public Space launched a call for papers inviting scholars, designers, planners, city practitioners, historians and writers to offer critical and innovative contributions to understanding meanings and practices in plural and diverse African spaces, contexts, climates, regional and local scales, and histories. The issue was intended to contribute to the establishment of the Centre on African Public Spaces (CAPS), a project initiated by the City of Johannesburg (South Africa) in collaboration with other African cities, universities and community advocacy groups. As a Pan-African urban lab for public space, CAPS was designed to be a home and resource to a community of urban practitioners and thinkers, students, scholars and civil society activists dedicated to connect, exchange experiences, advance knowledge, share resources, grow expertise and mobilize on a wide range of relevant local, regional and global issues. In response to the call for papers we received 70 submissions. We shortlisted 27 papers for this issue and we invited African scholars to serve as peer reviewers and to support the production of quality contents. The peer review process involved more than 60 African scholars and two African guest editors, for more than one year.
Length and Thickness of Vertebral Artery Groove of Dry Ossified Human Atlas Vertebra
Authors: Rahman Sadia , Ara Shamim , Sayeed Sharmina , Banu Masuma Akhtar , Kashem Kanetarin 
Published: April 2024

Context: The superior surface of the posterior arch of the atlas vertebra behind its lateral mass has a vertebral artery groove. The contents of this groove are third part of vertebral artery, venous plexus and first cervical nerve. Morphometric data of vertebral artery groove is helpful for the spine surgeons to avoid iatrogenic injury of these vital structures during posterior approach.
Materials and Methods: A cross-sectional, analytical type of study was conducted in the Department of Anatomy, Dhaka Medical College, Dhaka from January 2012 to July 2013. Inner and outer groove length and thickness of the vertebral artery groove was measured with the help of flexible metallic wire and digital slide calipers.
Results: There was no significant difference (P>0.10) in the mean length of inner border between right and left groove for vertebral artery. But outer border of left groove for vertebral artery was larger than right groove for vertebral artery (P<0.001). The mean thickness of the groove for the right and left vertebral artery was not significantly different (P>0.50).
Bangladesh J. Anat. 2015; 13(1) : 8-10
Correlation of Stature with Footprint of Bangladeshi Male Medical Students
Authors: Hossain Farhana , Ara Shamim , Shahana Nahid , Hasan Karim Rezwan 
Published: April 2024

Context: Foot dimension has great use in anatomy, physiology, ergonomics, forensic science, plastic surgery, radiology, podiatry, archaeology, anthropology, nutrition science and diagnostic knowledge between patient and normal population. The data of foot dimensions of Bangladeshi male is essential for the anatomist for normative reference. Stature can be correlated with foot dimensions using different foot segments from footprints. This cross sectional analytic study was planned to determine the different dimensions of the footprint of the Bangladeshi males and to find out the correlation of stature with foot dimensions from footprint of male Bangladeshi medical students.
Materials & Methods: Two hundred (200) male medical college students of 18-25 years of age were selected from different medical colleges of Dhaka city and their age was determined by their national ID cards. Stature was measured using a stadiometer. Both feet of the same individual were painted with ink with the help of the brush. After ensuring that toes and sole were inked properly, footprints were taken at the same time for both feet while the ink was still wet. Length of the different toes(t) were then measured in centimetre from the footprints using a Vernier digital caliper.
Results: In the present study, significant differences were observed between T1, T2, T3, T4 and T5 lengths of right and left foot (P<0.001). Each of the T1, T2, T3, T4 and T5 lengths of the left foot were greater than the right foot. There was a strong correlation between the stature and foot length among Bangladeshi males (P<0.001).
Conclusion: All the foot lengths of left footprint were significantly higher than the right footprint among Bangladeshi male medical students. Further studies with larger sample size are recommended to get more precise picture in order to produce a more comprehensive data that will help to determine the correlation of stature with dimensions of footprint of Bangladeshi medical students.
Bangladesh J. Anat. 2015; 13(1) : 16-22
Enhancing phosphorus use efficiency and soil quality indicators in lowland paddy ecosystem through Azolla, rice straw, and NPKS fertilizers
Authors: Marzouk Said H. , Tindwa Hamis J. , Amuri Nyambilila A. , Chande Hashim H. , Semoka Johnson M. 
Published: April 2024

PurposeThis study investigates the influence of incorporating Azolla, rice straw, and NPKS fertilizers on phosphorus use efficiency (PUE) and rice productivity in lowland paddy fields. Despite Azolla’s well-known role as a nitrogen-fixing aquatic fern in rice production, its specific impact on PUE remains unclear. The primary objective is to explore diverse treatment combinations to identify synergies that enhance both PUE and overall rice productivity.MethodsThe study was conducted at Mkula Irrigation Scheme in the Kilombero Valley, Tanzania; the field experiment employed a randomized complete block design with 13 treatments and three replications. Treatments comprised various combinations of Azolla, rice straw, and chemical fertilizers, incorporating 50% and 100% rates of nitrogen (N) applied with phosphorus (P), potassium (K), and sulfur (S).ResultsThe study reveals the substantial impact of Azolla application on total nitrogen, available phosphorus, and exchangeable potassium levels in the soil. Particularly noteworthy were treatment combinations involving Azolla, rice straw, and reduced rates of synthetic nitrogen, along with specific P, K, and S applications, which exhibited the highest phosphorus uptake and PUE. Specifically, combining rice straw and Azolla with reduced N rates, alongside 30 kg P ha−1 + 30 kg K ha−1 + 20 kg S ha−1, resulted in the highest phosphorus uptake (73.57 kg/ha) and PUE (46.24%).ConclusionIntegrated nutrient management, incorporating rice straw and Azolla alongside synthetic fertilizers, demonstrates synergistic effects on phosphorus uptake and efficiency while maintaining soil quality. The study underscores the potential of such integrated strategies to optimize PUE and contribute to sustainable rice production in lowland paddy fields.
NOX2 and NOX4 expression in monocytes and macrophages-extracellular vesicles in signalling and therapeutics
Authors: Rathi Deepak , Rossi Claudio , Pospíšil Pavel , Ramalingam Manoharan Renuka , Talarico Luigi , Magnani Agnese , Prasad Ankush 
Published: April 2024

Extracellular vesicles (EVs) are a type of cytoplasmic vesicles secreted by a variety of cells. EVs originating from cells have been known to participate in cell communication, antigen presentation, immune cell activation, tolerance induction, etc. These EVs can also carry the active form of Nicotinamide Adenine Dinucleotide Phosphate Oxidase Hydrogen (NADPH) oxidase, which is very essential for the production of reactive oxygen species (ROS) and that can then modulate processes such as cell regeneration. The aim of this study is to characterize the EVs isolated from U-937 and THP-1 cells, identify the NADPH oxidase (NOX) isoforms, and to determine whether EVs can modulate NOX4 and NOX2 in monocytes and macrophages. In our study, isolated EVs of U-937 were characterized using dynamic light scattering (DLS) spectroscopy and immunoblotting. The results showed that the exogenous addition of differentiation agents (either phorbol 12-myristate 13-acetate (PMA) or ascorbic acid) or the supplementation of EVs used in the study did not cause any stress leading to alterations in cell proliferation and viability. In cells co-cultured with EVs for 72 h, strong suppression of NOX4 and NOX2 is evident when monocytes transform into macrophagic cells. We also observed lower levels of oxidative stress measured using immunoblotting and electron paramagnetic resonance spectroscopy under the EVs co-cultured condition, which also indicates that EVs might contribute significantly by acting as an antioxidant source, which agrees with previous studies that hypothesized the role of EVs in therapeutics. Therefore, our results provide evidence for NOX regulation by EVs in addition to its role as an antioxidant cargo.
High progesterone levels on the day after HCG injection has no effect on clinical pregnancy outcomes in in vitro fertilization-embryo transfer
Authors: Liang Zhuo , Huang Qiuyan , Huang Jiwei , Wu Jinxiang , Zeng Dingyuan , Huang Pinxiu 
Published: April 2024

BackgroundThis study investigates the potential impact of high progesterone (P) level on the day following human chorionic gonadotropin (HCG) injection on the clinical pregnancy outcomes of in vitro fertilization-embryo transfer (IVF-ET).MethodsRetrospective analysis was conducted on 6418 cycles of IVF-ET performed at Liuzhou Maternal and Child Health Hospital between August 2020 to December 2021. Excluding cycles with progesterone levels ≥1.5ng/ml on HCG injection, a total of 781 cycles were identified according to the standard, and they were divided into five groups according to the progesterone level on the day after HCG: Group A: progesterone level &lt; 2.5 ng/ml (n = 128); Group B: 2.5 ng/ml ≤ progesterone level &lt; 3.5 ng/ml (n = 174); Group C: 3.5 ng/ml ≤ progesterone level &lt; 4.5 ng/ml (n = 153); Group D: 4.5 ng/ml ≤ progesterone level &lt; 5.5 ng/ml (n = 132); Group E progesterone level ≥5.5 ng/ml(n=194). Comparative analyses of clinical data, including general clinical data, and clinical pregnancy outcomes such as clinical pregnancy rate, miscarriage rate, and live birth rate were performed among these groups.ResultsThere were significant differences in estradiol levels on HCG injection, but there were no differences in available embryo rate, clinical pregnancy rate, miscarriage rate, and live birth rate. Binary logistic regression analysis showed that there was no significant correlation between P level on the day after HCG injection and the live birth rate.ConclusionUnder the condition of low P level on HCG injection, high progesterone levels on the day after HCG injection does not affect the clinical pregnancy outcomes of IVF-ET.
Cytogenomic characterization of small supernumerary marker chromosomes in patients with pigmentary mosaicism
Authors: Navarrete-Meneses M. P. , Ochoa-Mellado I. , Gutiérrez-Álvarez R. , Martínez-Anaya D. , Juárez-Figueroa U. , Durán-McKinster C. , Lieberman-Hernández E. , Yokoyama-Rebollar E. , Gómez-Carmona S. , Del Castillo-Ruiz V. , Pérez-Vera P. , Salas-Labadía C. 
Published: April 2024

Introduction:The combination of gene content on the marker chromosome, chromosomal origin, level of mosaicism, origin mechanism (chromothripsis), and uniparental disomy can influence the final characterization of sSMCs. Several chromosomal aberrations, including sSMCs, have been observed in 30%–60% of patients with pigmentary mosaicism, and in more than 80%, chromosomal abnormalities are present in the mosaic state. In patients with pigmentary mosaicism the most representative chromosomes involved in sSMCs are 3, 5, 6, 9, 10, 13, 15, 18, 20, and X. In this study, we included the complete clinical, cytogenetic, and molecular characterization of seven patients with pigmentary mosaicism associated with the presence of SMCs of different chromosomal origins.Methods:The patients were diagnosed by the Genetics and Dermatology Department of three different hospitals. Cytogenetic and FISH analyses were performed on peripheral blood, light skin, and dark skin. FISH analysis was performed using different probes, depending on the marker chromosome description. Different array analysis was performed.Results:To date, of the seven cases studied, the chromosomal origins of six were successfully identified by FISH or array analysis. The chromosomes involved in SMCs were 6, 9, 15, and 18, X. The most frequently found was the centric minute structure.Discussion:To date, this group of seven patients constitutes the largest clinical and cytogenetically finely described study of cases with pigmentary mosaicism associated with sSMCs. Undoubtedly, analysis of the two skin types is a fundamental part of our study, as numerical differences may occur in the cell lines found in each skin type. The knowledge generated in this study will help delineate a very heterogeneous entity more accurately, and in the future, analyzing more patients with PM will likely establish a more definite association with the presence of this genetic alteration.
Transcriptomic atlas for hypoxia and following re-oxygenation in Ancherythroculter nigrocauda heart and brain tissues: insights into gene expression, alternative splicing, and signaling pathways
Authors: Chen Jian , Hu Zhen , Li Pei , Wang Guiying , Wei Huijie , Li Qing , Fu Beide , Sun Yanhong 
Published: April 2024

Hypoxia is a mounting problem that affects the world’s freshwaters, with severe consequence for many species, including death and large economical loss. The hypoxia problem has increased recently due to the combined effects of water eutrophication and global warming. In this study, we investigated the transcriptome atlas for the bony fish Ancherythroculter nigrocauda under hypoxia for 1.5, 3, and 4.5 h and its recovery to normal oxygen levels in heart and brain tissues. We sequenced 21 samples for brain and heart tissues (a total of 42 samples) plus three control samples and obtained an average of 32.40 million raw reads per sample, and 95.24% mapping rate of the filtered clean reads. This robust transcriptome dataset facilitated the discovery of 52,428 new transcripts and 6,609 novel genes. In the heart tissue, the KEGG enrichment analysis showed that genes linked to the Vascular smooth muscle contraction and MAPK and VEGF signaling pathways were notably altered under hypoxia. Re-oxygenation introduced changes in genes associated with abiotic stimulus response and stress regulation. In the heart tissue, weighted gene co-expression network analysis pinpointed a module enriched in insulin receptor pathways that was correlated with hypoxia. Conversely, in the brain tissue, the response to hypoxia was characterized by alterations in the PPAR signaling pathway, and re-oxygenation influenced the mTOR and FoxO signaling pathways. Alternative splicing analysis identified an average of 27,226 and 28,290 events in the heart and brain tissues, respectively, with differential events between control and hypoxia-stressed groups. This study offers a holistic view of transcriptomic adaptations in A. nigrocauda heart and brain tissues under oxygen stress and emphasizes the role of gene expression and alternative splicing in the response mechanisms.
Meta-analysis of differential gene expression in lower motor neurons isolated by laser capture microdissection from post-mortem ALS spinal cords
Authors: Swindell William R. 
Published: April 2024

IntroductionALS is a fatal neurodegenerative disease for which underlying mechanisms are incompletely understood. The motor neuron is a central player in ALS pathogenesis but different transcriptome signatures have been derived from bulk analysis of post-mortem tissue and iPSC-derived motor neurons (iPSC-MNs).MethodsThis study performed a meta-analysis of six gene expression studies (microarray and RNA-seq) in which laser capture microdissection (LCM) was used to isolate lower motor neurons from post-mortem spinal cords of ALS and control (CTL) subjects. Differentially expressed genes (DEGs) with consistent ALS versus CTL expression differences across studies were identified.ResultsThe analysis identified 222 ALS-increased DEGs (FDR &lt;0.10, SMD &gt;0.80) and 278 ALS-decreased DEGs (FDR &lt;0.10, SMD &lt; −0.80). ALS-increased DEGs were linked to PI3K-AKT signaling, innate immunity, inflammation, motor neuron differentiation and extracellular matrix. ALS-decreased DEGs were associated with the ubiquitin-proteosome system, microtubules, axon growth, RNA-binding proteins and synaptic membrane. ALS-decreased DEG mRNAs frequently interacted with RNA-binding proteins (e.g., FUS, HuR). The complete set of DEGs (increased and decreased) overlapped significantly with genes near ALS-associated SNP loci (p &lt; 0.01). Transcription factor target motifs with increased proximity to ALS-increased DEGs were identified, most notably DNA elements predicted to interact with forkhead transcription factors (e.g., FOXP1) and motor neuron and pancreas homeobox 1 (MNX1). Some of these DNA elements overlie ALS-associated SNPs within known enhancers and are predicted to have genotype-dependent MNX1 interactions. DEGs were compared to those identified from SOD1-G93A mice and bulk spinal cord segments or iPSC-MNs from ALS patients. There was good correspondence with transcriptome changes from SOD1-G93A mice (r ≤ 0.408) but most DEGs were not differentially expressed in bulk spinal cords or iPSC-MNs and transcriptome-wide effect size correlations were weak (bulk tissue: r ≤ 0.207, iPSC-MN: r ≤ 0.037).ConclusionThis study defines a robust transcriptome signature from LCM-based motor neuron studies of post-mortem tissue from ALS and CTL subjects. This signature differs from those obtained from analysis of bulk spinal cord segments and iPSC-MNs. Results provide insight into mechanisms underlying gene dysregulation in ALS and highlight connections between these mechanisms, ALS genetics, and motor neuron biology.
Additional prognostic value of polymorphisms within the 3′-untranslated region of programmed cell death pathway genes in early-stage breast cancer
Authors: Chen Hanxi , Chen Minyan , Zeng Bangwei , Tang Lili , Nie Qian , Jin Xuan , Guo Wenhui , Chen Lili , Lin Yuxiang , Wang Chuan , Fu Fangmeng 
Published: April 2024

IntroductionThe programmed cell death (PCD) pathway plays an important role in restricting cancer cell survival and proliferation. However, limited studies have investigated the association between genetic variants in the 3′-untranslated region of the PCD pathway genes and breast cancer outcomes.MethodsIn this study, we genotyped 28 potentially functional single nucleotide polymorphisms (SNPs) in 23 PCD pathway genes in 1,177 patients with early-stage breast cancer (EBC) from a Han Chinese population. The median follow-up period was 174 months.ResultsAmong all the candidate SNPs, four independent SNPs (rs4900321 and rs7150025 in ATG2B, rs6753785 in BCL2L11, and rs2213181 in c-Kit) were associated with invasive disease-free survival (iDFS), distant disease-free survival (DDFS), breast cancer-specific survival (BCSS) and overall survival (OS), respectively. Further combined genotypes of these four SNPs revealed that the survival decreased as the number of unfavorable genotypes increased (Ptrend = 1.0 × 10−6, 8.5 × 10−8, 3.6 × 10−4, and 1.3 × 10−4 for iDFS, DDFS, BCSS, and OS, respectively). Receiver operating characteristic curve analysis demonstrated that incorporating unfavorable genotypes and clinicopathological variables improved the ability to predict EBC survival (P = 0.006, 0.004, 0.029, and 0.019 for iDFS, DDFS, BCSS, and OS, respectively). Additionally, rs6753785 and rs2213181 were associated with BCL2L11 and c-Kit mRNA expression, respectively.ConclusionsOur results suggest that these four SNPs may act as novel biomarkers for EBC survival, possibly by modulating the expression of the corresponding genes.