bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and validation of a prognostic model for predicting post-discharge mortality risk in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI)
Authors: Zhang Lingling , Liu Zhican , Zhu Yunlong , Wu Mingxin , Huang Haobo , Yang Wenbin , Peng Ke , Zeng Jianping 
Published: March 2024

Abstract
Background
Accurately predicting post-discharge mortality risk in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI) remains a complex and critical challenge. The primary objective of this study was to develop and validate a robust risk prediction model to assess the 12-month and 24-month mortality risk in STEMI patients after hospital discharge.

Methods
A retrospective study was conducted on 664 STEMI patients who underwent PPCI at Xiangtan Central Hospital Chest Pain Center between 2020 and 2022. The dataset was randomly divided into a training cohort (n = 464) and a validation cohort (n = 200) using a 7:3 ratio. The primary outcome was all-cause mortality following hospital discharge. The least absolute shrinkage and selection operator (LASSO) regression model was employed to identify the optimal predictive variables. Based on these variables, a regression model was constructed to determine the significant predictors of mortality. The performance of the model was evaluated using receiver operating characteristic (ROC) curve analysis and decision curve analysis (DCA).

Results
The prognostic model was developed based on the LASSO regression results and further validated using the independent validation cohort. LASSO regression identified five important predictors: age, Killip classification, B-type natriuretic peptide precursor (NTpro-BNP), left ventricular ejection fraction (LVEF), and the usage of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers/angiotensin receptor-neprilysin inhibitors (ACEI/ARB/ARNI). The Harrell's concordance index (C-index) for the training and validation cohorts were 0.863 (95% CI: 0.792–0.934) and 0.888 (95% CI: 0.821–0.955), respectively. The area under the curve (AUC) for the training cohort at 12 months and 24 months was 0.785 (95% CI: 0.771–0.948) and 0.812 (95% CI: 0.772–0.940), respectively, while the corresponding values for the validation cohort were 0.864 (95% CI: 0.604–0.965) and 0.845 (95% CI: 0.705–0.951). These results confirm the stability and predictive accuracy of our model, demonstrating its reliable discriminative ability for post-discharge all-cause mortality risk. DCA analysis exhibited favorable net benefit of the nomogram.

Conclusion
The developed nomogram shows potential as a tool for predicting post-discharge mortality in STEMI patients undergoing PPCI. However, its full utility awaits confirmation through broader external and temporal validation.
Antiplasmodial potential of phytochemicals from Citrus aurantifolia peels: a comprehensive in vitro and in silico study
Authors: Elmaidomy Abeer H. , Abdelmohsen Usama Ramadan , Sayed Ahmed M. , Altemani Faisal H. , Algehainy Naseh A. , Soost Denisa , Paululat Thomas , Bringmann Gerhard , Mohamed Esraa M. 
Published: March 2024

AbstractPhytochemical investigation of Key lime (Citrus aurantifolia L., F. Rutaceae) peels afforded six metabolites, known as methyl isolimonate acetate (1), limonin (2), luteolin (3), 3ˋ-hydroxygenkwanin (4), myricetin (5), and europetin (6). The structures of the isolated compounds were assigned by 1D NMR. In the case of limonin (2), further 1- and 2D NMR experiments were done to further confirm the structure of this most active metabolite. The antiplasmodial properties of the obtained compounds against the pathogenic NF54 strain of Plasmodium falciparum were assessed in vitro. According to antiplasmodial screening, only limonin (2), luteolin (3), and myricetin (5) were effective (IC50 values of 0.2, 3.4, and 5.9 µM, respectively). We explored the antiplasmodial potential of phytochemicals from C. aurantifolia peels using a stepwise in silico-based analysis. We first identified the unique proteins of P. falciparum that have no homolog in the human proteome, and then performed inverse docking, ΔGBinding calculation, and molecular dynamics simulation to predict the binding affinity and stability of the isolated compounds with these proteins. We found that limonin (2), luteolin (3), and myricetin (5) could interact with 20S a proteasome, choline kinase, and phosphocholine cytidylyltransferase, respectively, which are important enzymes for the survival and growth of the parasite. According to our findings, phytochemicals from C. aurantifolia peels can be considered as potential leads for the development of new safe and effective antiplasmodial agents.
Determination of indoxyl sulfate by spectrofluorimetric method in human plasma through extraction with deep eutectic solvent
Authors: Shafiee Samira , Dastmalchi Siavoush , Gharekhani Afshin , Shayanfar Ali 
Published: March 2024

AbstractA rapid and efficient analytical method was established to quantify indoxyl sulfate (IS) in plasma through extraction technique with a deep eutectic solvent (DES) and spectrofluorimetric method. DES (choline chloride: urea) was mixed with plasma samples for the extraction of IS, followed by the addition of dipotassium hydrogen phosphate (K2HPO4) solution to form an aqueous two-phase system. The fluorescence intensity of IS which was first extracted to the DES-rich-phase and then back-extracted into the salt-rich-phase, was measured by spectrofluorimetric method. Some key factors such as pH, centrifugation speed and time, the volume ratio of DES/salt, and salt concentration were optimized. Under the optimized conditions, the suggested method had a dynamic range between 20 and 160 µg/mL with a coefficient of determination (R2) of 0.99. Precision (relative standard deviation) was less than 15% and accuracy (% relative recovery) was ± 15% at the nominal concentration level. In addition, results showed that IS levels in real samples were higher than 40 µg/mL which was compatible with reported IS levels in end-stage renal disease (ESRD) patients. Overall, all the results reflect the fact that the presented analytical method can potentially be used for the determination of IS in real plasma samples.
Management of cardiogenic shock: a narrative review
Authors: Laghlam Driss , Benghanem Sarah , Ortuno Sofia , Bouabdallaoui Nadia , Manzo-Silberman Stephane , Hamzaoui Olfa , Aissaoui Nadia 
Published: March 2024

AbstractCardiogenic shock (CS) is characterized by low cardiac output and sustained tissue hypoperfusion that may result in end-organ dysfunction and death. CS is associated with high short-term mortality, and its management remains challenging despite recent advances in therapeutic options. Timely diagnosis and multidisciplinary team-based management have demonstrated favourable effects on outcomes. We aimed to review evidence-based practices for managing patients with ischemic and non-ischemic CS, detailing the multi-organ supports needed in this critically ill patient population.
Investigation of safety and efficacy of febantel and fenbendazole in fish and exposure assessment
Authors: Kim Min Ji , Kim Ji Young , Shin Dong Woo , Kim Hyun-Kyung 
Published: March 2024

AbstractFish are susceptible to blood-sucking parasite infections, which cause severe anemia, dyspnea, and ultimately death. However, veterinary drugs available for fish to treat such infectious diseases are lacking; thus, livestock drugs have been repurposed as aquatic animal drugs. Febantel (FBT) and fenbendazole (FBZ) are representative antiparasitic agents for livestock such as cattle, swine, and poultry, and are considered suitable as aquatic animal drugs. Therefore, we investigated the safety and efficacy of FBT and FBZ in fish and performed a risk assessment to determine the maximum residue limit in fish. Most studies indicate that FBT is rapidly converted to FBZ, which is metabolized to oxfendazole and oxfendazole sulfone. FBZ was frequently detectable in the plasma and tissues (e.g., muscle, skin, and the liver) in significant quantities than other metabolites. We regarded the liver as the target organ because reversible hepatocytic changes were observed in fish after administration of 100 mg/kg FBT for 9 days. No toxicological effects, such as increased mortality or decreased appetite, were observed when the fish were administered 50 mg/kg FBT for 3 days. The efficacy of the drugs was verified in various parasites, including H. heterocerca, H. okamotoi or Z. japonica, and M. seriolae, as causative agents of beko disease through laboratory and field trials. Although toxicity studies on FBZ in fish are limited, its safety has been demonstrated from toxicity studies in a wide range of animal models. The risk from using FBT and FBZ was negligible for human health because the ratio of the estimates of dietary exposure and acceptable daily intake was 78.4%.
A narrative review of non-invasive brain stimulation techniques in neuropsychiatric disorders: current applications and future directions
Authors: Aderinto Nicholas , Olatunji Gbolahan , Muili Abdulbasit , Kokori Emmanuel , Edun Mariam , Akinmoju Olumide , Yusuf Ismaila , Ojo Deborah 
Published: March 2024

Abstract
Background
Neuropsychiatric disorders significantly burden individuals and society, necessitating the exploration of innovative treatment approaches. Non-invasive brain stimulation techniques have emerged as promising interventions for these disorders, offering potential therapeutic benefits with minimal side effects. This narrative review provides a comprehensive overview of non-invasive brain stimulation techniques' current applications and future directions in managing neuropsychiatric disorders.

Methods
A thorough search of relevant literature was conducted to identify studies investigating non-invasive brain stimulation techniques in neuropsychiatric disorders. The selected studies were critically reviewed, and their findings were synthesised to provide a comprehensive overview of the current state of knowledge in the field.

Results
The review highlights the current applications of non-invasive brain stimulation techniques in neuropsychiatric disorders, including major depressive disorder, Parkinson's disease, schizophrenia, insomnia, and cognitive impairments. It presents evidence supporting the efficacy of these techniques in modulating brain activity, alleviating symptoms, and enhancing cognitive functions. Furthermore, the review addresses challenges such as interindividual variability, optimal target site selection, and standardisation of protocols. It also discusses potential future directions, including exploring novel target sites, personalised stimulation protocols, integrating with other treatment modalities, and identifying biomarkers for treatment response.

Conclusion
Non-invasive brain stimulation techniques offer promising avenues for managing neuropsychiatric disorders. Further research is necessary to optimise stimulation protocols, establish standardised guidelines, and identify biomarkers for treatment response. The findings underscore the potential of non-invasive brain stimulation techniques as valuable additions to the armamentarium of neuropsychiatric treatments.
Factors Affecting Student Drop Out Behavior: A Systematic Review
Authors: Banaag Rethse , Sumodevilla Jasmine Louise , Potane Joel 
Published: March 2024

Factors affecting student dropout behavior have been investigated overtime. A lot of factors came out to be affecting this prevalent concern in schools. However, in this study, a systematic review of peer-reviewed, empirical literature and studies published between 2015- 2023 was conducted to identify the common factors affecting student dropout behavior and interventions implemented to minimize dropout rates. This review specifically tackles two key issues: First, what are the common factors affecting student dropout behavior? Second, what are the common initiatives and or interventions in reducing student dropouts? A total of 12 studies were included in the review which passed the PRISMA diagram guidelines, Critical Appraisal Skills Programme (CASP) checklist, and were organized using a literature matrix. Results showed that family, school, school/teacher, lack of guidance and counseling, social, individual, and socioeconomic factors were the common factors influencing student dropout behavior. Additionally, it showed that remedial programs addressing lack of interest, support and resources, improving the school's guidance program, offering mechanisms for support to counteract the impact of poverty, transportation and counseling services, increased funding for disadvantaged students, raising awareness of the consequences of pre-marital sex, enforcing school dropout policies, integrating sex education, and guaranteeing adequate resource availability were common interventions implemented to address these prevalent factors. The findings emphasized the importance of tailored and contextualized interventions in addressing the specific factors. Further research is needed to identify interventions that tailor-fit each factor to structure a more efficient and effective program to address issues related to student dropouts.
Osh risk management of tank sinking procedure using bow tie analysis on the construction of a shell gasoline station in Surabaya
Authors: Wijaya Oktomi , Sugiyana Laely Ufiz Tsani 
Published: March 2024

Introduction: The rate of work accidents in the construction sector is still high. Such a situation has led to the need for risk management in the area of Occupational Safety and Health (OSH). This study is aimed at finding the OSH risk management of the tank sinking procedure using Bow Tie Analysis method in the construction of a Shell Gasoline Station in Surabaya.
Methods: This is a qualitative descriptive study with case study design. The subjects of the study were the employees of PT Usaha Jaya Engineering who worked on the Tank Sinking procedure in the construction of a Shell Gasoline Station in Surabaya with the minimum service period of 2 years and with a total number of 7 people. Data collection was executed using primary data derived from interviews and field observation as well as secondary data in the forms of supporting documents from the company.
Results: As many as 9 hazards were found in the tank sinking procedure in the construction of a Shell Gasoline Station in Surabaya. These hazards were caused by 5 factors, i.e., human, machine/equipment, method, material, and environment. The possible consequence of such hazards is that the employees may experience light to serious injuries and even fatality. Prevention and mitigation measures might be implemented in 4 hierarchical steps of risk management, i.e., substitution, technical management, administrative management, and personal protective equipment (PPE). This study found 6 escalation factors and the barrier of escalation factor in the tank sinking process.
Conclusion: The tank sinking procedure in the construction of a Shell Gas Station in Surabaya was a job with risks of work accident. Prevention and mitigation measures derived from the Bow Tie analysis might be implemented to prevent work accidents from occurring.
Correlation between implementation of health protocol and compliance among employees of Mutiara department store Slawi in the prevention of Covid-19
Authors: Pratiwi Anggit , Subekti Agung Tyas , Rakhmadi Triyono 
Published: March 2024

Background: Covid-19 pandemic has affected various aspects. One of them is the shopping center/retail sector since a shopping center is a place which is susceptible to the dissemination of SARS-CoV-2 viruses so that health protocols should be implemented and employees should comply with the health protocols in the workplace.
Objective: The study is aimed at finding the correlation between the implementation of Covid-19 health protocols and compliance among employees of Mutiara Cahaya Department Store Slawi.
Method: This is a quantitative correlative study with cross-sectional design. The research subjects were all employees of Mutiara Cahaya Department Store Slawi with the sample consisting of 48 respondents.
Data Analysis: Data were analyzed using a univariate test in the form of frequency distribution and a bivariate test using Chi-Square. The results of the analysis showed that the implementation of Covid-19 health protocols in Mutiara Cahaya Department Store Ciawi ran quite well (39.59%) with employees’ compliance which was good as well (64.58%). The results of the research showed that there was a significant correlation between the implementation of health protocols and employees’ compliance with (pValue = 0,000) meaning that if the health protocol is good then the employees’ compliance is also good.
Conclusion: Compliance with the implementation of health protocol which has been performed by the employees and management of Mutiara Cahaya Department Store Ciawi included mask wearing, hand washing, temperature check for employees and visitors, limitation of operational hours, provision of >1 meter distancing marks, installation of separators on cashier desks, and workplace cleaning with disinfectants.
Analysis of cleanliness, health, safety, and environmental sustainability in Merapi disaster-prone tourist villages
Authors: Wijaya Oktomi , Putra Bayu Cahya Eka 
Published: March 2024

Background: Covid-19 pandemic has brought enormous effect on tourism sector. Covid-19 transmission can be prevented by the implementation of cleanliness, health, safety, and environmental sustainability (CHSE) aspects. This study aims to analysis the implementation of CHSE based on the Indonesian National Standard No. 9042 of 2021 (Standar Nasional Indonesia No.9042 Tahun 2021).
Method: This was a quantitative study with survey design executed using CHSE guidelines of the Indonesian National Standard No. 9042 of 2021. The research sample consisted of 68 tourist cottages which were selected using total sampling technique. The research instrument was CHSE checklist to measure the implementation of CHSE in the tourist cottages.
Results: Results of the study showed that the implementation of CHSE in tourist cottages in three tourist villages of Nganggring, Tunggul Arum, and Penting Sari were categorized as low with the scores of 22.90% for management, 37.02% for human resources, and 27.46% for guest participation.
Conclusion: CHSE implementation in three tourist villages of Nganggring, Tunggul Arum, and Penting Sari has not be done in maximum manner so that the scores for each of the indicators of management, human resources, and guest participation were categorized as low.
Excess Thermodynamic Parameters of Binary Liquid Mixtures of Dimethyl Malonate with Isomeric Xylenes at Different Temperatures
Authors: Pavan Krishna K , Sandhya Sri P.B. , Sekhar D. Chandra , Balaji Gupta T.V.L.N. , Satyanarayana R.L. 
Published: March 2024

Over the complete composition range of mole fractions, densities and ultrasonic velocities of binary liquid mixtures of dimethyl malonate with o-xylene, p-xylene and m-xylene were investigated at 303.15-318.15 K. These parameters were chosen to investigate the impact of substituents and specific locations on several thermodynamic characteristics of binary mixtures. The deviation in adiabatic compressibility (∆βad), excess molar volume (VE) and excess intermolecular free length (LfE) were estimated using the experimental measurements. These extraneous parameters are fitted to a polynomial equation of the Redlich-Kister type. Along with the obtained parameter values, the standard deviation (σ) was also determined.
Evaluation of Meibomian Glands and Tear Film in Pterygium Patients
Authors: Praveen Kavalanayak Kurahatti  , Niharika Krishna Shetty  
Published: March 2024

BACKGROUND
In this study we wanted to estimate the tear film and meibomian gland abnormalities in pterygium patients, and compare the tear film in pterygium eye with non pterygium eye.
METHODS
This was a prospective study conducted in the outpatient department of ophthalmology of Adichunchanagiri institute of Medical sciences, Bellur, Mandya. A TBUT of <10 secs, Schirmer <10 secs and Meibomian glands <1/3 of lid area considered to be abnormal.
RESULTS
The Schirmer’s test showed 41.1% of dry eye out of which 28.8% was mild, 12.3% was moderate dry eye disease. And TBUT test showed 51.1% dry eye out of which 31.2% was mild, 8.8% was moderate and 11.1% was severe dry eye disease. 27(30%) patients had grade 1, 26(28.9) patients with grade 2 and 24(26.7) patients with grade 3 meibomian gland disorder. In eyes with pterygium, results were significantly different.
CONCLUSIONS
Meibomian gland and tear film may be altered in patients having pterygium, which may lead to ocular discomfort and dry eye.
IL-33/soluble ST2 axis is associated with radiation-induced cardiac injury
Authors: Yasen Xiaokeya , Aikebaier Renaguli , Maimaiti Atiguli , Mushajiang Munire 
Published: March 2024

Abstract
Radiotherapy for treating breast cancer is associated with cardiac damage. This study aimed to investigate the role of the interleukin (IL)-33/soluble receptor ST2 (sST2) axis in radiation-induced cardiac injury. Expressions of IL-33 and sST2 were detected in breast cancer patients following radiotherapy, radiation-induced cardiac damaged mice model, and cardiomyocytes using quantitative real-time PCR (qRT-PCR) and immunohistochemical assay. Cardiac injury was evaluated through an ultrasound imaging system and hematoxylin & eosin staining. The transcriptional factor was assessed using dual-luciferase reporter assay and chromatin immunoprecipitation. The results indicated that IL-33 and sST2 were highly expressed in breast cancer patients, which further elevated post-6 months but reduced after 12 months of radiotherapy. Radiation induces cardiac dysfunction and elevated IL-33 and sST2 levels in a time-dependent manner. However, silencing of IL-33 decreased sST2 expression to alleviate radiation-induced cardiac dysfunction. The IL-33 could be transcriptional activated by TCF7L2 by binding to IL33 promoter sites, which mutation alleviated cardiomyocyte injury caused by radiation. Additionally, radiation treatment resulted in higher levels of TCF7L2, IL-33, and sST2 in cardiomyocytes, and TCF7L2 knockdown reduced IL-33 and sST2 expression. In conclusion, TCF7L2 transcriptional-activated IL-33 mediated sST2 to regulate radiation-induced cardiac damage, providing novel insights into radiotherapy-induced cardiac damage.
Influence of unsupported sleepers on flange climb derailment of two freight wagons
Authors: Matej Jan , Seńko Jarosław , Caban Jacek , Szyca Mikołaj , Gołębiewski Hubert 
Published: March 2024

Abstract
Two freight platform wagons connected together conventionally or in the form of so-called rigid connection were taken into account to investigate the influence of unsupported sleepers on climb flange derailment on transition curve. Presented results are related to the freight wagons equipped with two-axle Y25 standard bogies, entering at an acceptable speed in the transition curve of the track with the radius of 150 or 1,000 m. Three cases have been analyzed: only the inner rail, only the outer rail, or both rails had unsupported sleepers. Simulation models were prepared using the VI-Rail software and nonlinear wheel–rail contact model. The dynamic calculations showed that wheel flange climb derailment caused by unsupported sleepers will only occur if deflection of the rail or track on transition curve is deep enough. These tests allowed us to determine the relationship between the radius of curvature and the depth of the trough causing derailment of the wagons. Calculation results allowed us to answer also the questions whether the method of connection and the weight of freight wagons have a significant impact on the wheel flange climb derailment.