bluuebunny/crossref_metadata_2025_split huggingface dataset:
Orforglipron, a novel non‐peptide oral daily glucagon‐like peptide‐1 receptor agonist as an anti‐obesity medicine: A systematic review and meta‐analysis
Authors: Dutta Deep , Nagendra Lakshmi , Anne Beatrice , Kumar Manoj , Sharma Meha , Kamrul‐Hasan A. B. M. 
Published: February 2024

AbstractBackgroundOrforglipron is a novel once‐daily oral non‐peptide glucagon‐like peptide‐1 receptor agonist with several recently published randomized controlled trials (RCTs) evaluating its role in diabetes and obesity. No meta‐analysis has analyzed the efficacy and safety of orforglipron; this meta‐analysis aimed to address this knowledge gap.MethodsA systematic search was conducted in electronic databases to identify RCTs that included individuals with obesity who were administered orforglipron and compared to either a placebo or an active comparator. The primary outcome of interest was the percent change in body weight.ResultsFrom 12 initially screened articles, data from three RCTs involving 774 people were analyzed with a follow‐up duration of up to 36 weeks. Compared to placebo, patients receiving orforglipron 12 mg/day (mean difference (MD), MD −5.48%, 95% CI [−7.64, −3.33], p < 0.01), 24 mg/day (MD −8.51%, 95% confidence interval (CI) [−9.88, −7.14], p < 0.01), 36 mg/day (MD −8.84%, 95% CI [−11.68, −6.00], p < 0.01) and 45 mg/day (MD −8.24%, 95% CI [−12.84, −3.63], p < 0.01) had a significantly greater percent reduction in body weight. The percentage of patients being able to achieve >15% weight loss from baseline was significantly higher with orforglipron 24 mg/day [Odds ratio (OR) 21.90 (95% CI [4.06, 118.15], p = 0.0003), 36 mg/day (OR 17.43, 95% CI [3.18, 95.66], p = 0.001) and 45 mg/day (OR 23.17, 95% CI [4.37, 123.03], p = 0.0002). Total but not severe adverse events were significantly higher with all the doses of orforglipron compared to placebo, with the hazard ratios being higher with higher doses. Gastrointestinal side‐effects were predominant side effects, being dose‐dependent, with nausea, vomiting, constipation, and gastroesophageal reflux being the predominant ones.ConclusionOrforglipron at 24–45 mg/day doses is an effective weight loss medication. The efficacy versus side effect profile suggests that 24–36 mg/day is the most optimal dose for orforglipron as an anti‐obesity medicine.
Assessment of microwave drying for rapid and convenient analysis of medicinal plants for quality assurance
Authors: Bala Esha , Dey Saurav , Patra Sanjukta , Singha Siddhartha 
Published: February 2024

AbstractIntroductionThe safety and quality of many medicinally important herbs are compromised since farmers and small organizations are involved in the cultivation, aggregation, and primary processing of these herbs. Such organizations often lack adequate quality control facilities. To improve the safety and quality of herbal products, simple, rapid, and affordable quality control systems are required.ObjectivesThe aim of this study was to assess the suitability of microwave oven‐drying for moisture content (MC) determination and sample preparation of herbs in small organizations.MethodsMicrowave oven‐drying (720 W) and convective oven‐drying at 105°C for MC determination were compared. The effects of three different drying methods (microwave oven‐drying, low‐temperature convective drying, and freeze‐drying) on in vitro antioxidant and polyphenol oxidase (PPO) activity were determined, similarity analysis was conducted using HPLC signature spectra, and validation was performed with LC‐MS focusing on one herb.ResultsMicrowave oven‐drying at 720 W significantly reduced the drying time (from hours to minutes), whereas the spatial variation of temperature in convective ovens set at 105°C can cause about 10% underestimation of MC. Microwave oven‐drying showed similar macro‐properties like freeze‐drying and higher extractability (10%–20%) and in vitro antioxidant capacity (33%–66%) and lower PPO activity compared to low‐temperature convective drying. HPLC signature spectra revealed strong similarity of soluble components between freeze‐dried and microwave oven‐dried herbs. LC‐MS analysis demonstrated more common compounds between freeze‐dried and microwave oven‐dried Centella asiatica extracts, whereas convective tray‐dried samples had fewer compounds common with samples obtained by freeze‐drying or microwave oven‐drying.ConclusionsMicrowave oven‐drying is rapid (tens of min) and shows small batch‐to‐batch variation compared to oven‐drying at 105°C. The in vitro antioxidant assays and signature spectra can be used for assessing the source and purity or quality of a specific herb variety.
Digital interventions for autism spectrum disorders: A systematic review and meta‐analysis
Authors: Wang Tianqi , Ma Yu , Du Xiaonan , Li Chunpei , Peng Zhongbi , Wang Yi , Zhou Hao 
Published: February 2024

ABSTRACTImportanceDigital technology is now widely available for the interventions of autism, but its validity and feasibility remain to be proved.ObjectiveThis study aimed to investigate the effectiveness of digital health interventions (DHIs) in improving core symptoms or intelligence quotient in patients with autism spectrum disorder (ASD).MethodsThree databases including PubMed, Cochrane, and Scopus, were searched on November 15, 2022. Randomized clinical trials that enrolled patients with ASD who received DHIs and a control group without DHI treatment were included. Cochrane risk of bias tool (RoB 2) was applied to assess the risk of bias.ResultsA total of 33 studies, involving 1285 participants (658 [51.2%] in DHI groups and 627 [48.8%] in control groups), were analyzed to investigate the differences between DHI groups and control groups. Significantly greater improvements in the overall performance of ASD were observed in the DHI groups compared to the control groups (including active, waitlist, treatment‐as‐usual, and no treatment) with an effect size of 1.89 (Cohen's d 95% confidence interval [CI]: 1.26–2.52). Studies with treatment‐as‐usual, waitlist, and no treatment control demonstrated large effect sizes of Cohen's d 3.41 (95% CI: 0.84–5.97), Cohen's d 4.27 (95% CI: 1.95–6.59), and Cohen's d 4.52 (95% CI: 2.98–6.06) respectively. In contrast, studies with active control revealed insignificant effect sizes (Cohen's d 0.73, 95% CI: 0.12–1.33).InterpretationThis meta‐analysis found significantly greater improvements in core symptoms or intelligence quotient in ASD patients receiving DHIs compared to those in control conditions. ASD patients may benefit from the DHIs and reduce the economic burden.
Development of a high‐pressure infiltration process for phenol–formaldehyde matrix composites
Authors: Weiler Samuel , Schwartzkopf Patrick , Haffner Henry , Chandrashekhara K 
Published: February 2024

AbstractPhenol–formaldehyde (phenolic) thermosets are known for excellent heat and chemical resistance, high flame retardance, and good mechanical performance. However, phenolics are also known for their high brittleness, and tendency to form voids, due to a condensation reaction forming water during curing. These voids can decrease the mechanical performance of the resultant phenolic composite and introduce undesirable performance characteristics. This work aims to develop a technique that uses high‐pressure infiltration to obtain dense phenolic matrix composites, with commercially available resin and fiber reinforcement. The high‐pressure system developed in this work is compared to a conventional low‐pressure resin infusion technique, and the porosity after each infusion is analyzed. A model of the low‐ and high‐pressure systems was developed, and the predicted time of infiltration was compared to the experimental results. The high‐pressure system had 97% less open porosity after infusion than the low‐pressure technique, suggesting that it can produce a higher‐quality and better‐performing phenolic composite than conventional techniques. Also, the mechanical test performed indicates improved performance for the high‐pressure injection with a 30.73% increase in ultimate tensile strength in comparison to low pressure, indicating better mechanical performance. © 2024 Society of Industrial Chemistry.
Evaluation of the cardiac safety of parsaclisib, a selective PI3Kδ inhibitor, in patients with previously treated B‐cell malignancies: Results from the CITADEL‐101 study
Authors: Li Jia , Gong Xiaohua , Liu Xing , Liu Xiang , Szeto Ke , Chen Xuejun 
Published: February 2024

AbstractParsaclisib, a potent and selective phosphatidylinositol 3 kinase δ inhibitor, has been investigated for the treatment of B‐cell malignancies and studied in patients with autoimmune diseases and myelofibrosis. The CITADEL‐101 study (NCT02018861) assessed safety, tolerability, and preliminary efficacy of parsaclisib in patients with relapsed or refractory non‐Hodgkin lymphoma. This study evaluated the cardiac safety of parsaclisib as monotherapy based on data from 72 patients enrolled in the CITADEL‐101 study. Time‐matched pharmacokinetic and ECG measurements were collected at specified times for 69 patients receiving monotherapy in doses of 5, 10, 15, 20, 30, and 45 mg once daily. Based on the categorical outlier analysis, no dose‐dependent effect was observed on the incidence of outliers in QT interval corrected for heart rate (HR) by Fridericia's method (QTcF), HR, or cardiac conduction. Based on central tendency analysis, the least square means (LSMs) (90% confidence interval [CI]) of ΔQTcF from the central tendency analysis ranged from −6.83 (−18.8 to 5.19) to 4.75 ms (0.410–9.09) across dose groups (below 20 ms, the threshold of large QT effects) and was not considered dose dependent. Moreover, the LSMs of ΔHR, ΔPR interval, and ΔQRS interval were minor. From the concentration‐ΔQTcF analyses, the predicted ΔQTcF (90% CI) for all dose levels was between 0.365 (−1.75 to 2.48) and 7.87 ms (0.921–14.8), with the highest upper limit of CIs well below 20 ms, and therefore, a large QT/QTc effect was ruled out up to the highest dose level (45 mg) investigated. Overall, parsaclisib at the dose ranges studied did not reveal concentration‐dependent effects on change in QTcF and did not have a significant effect on HR or cardiac conduction.
Nut bush pesticide limits: urgent need for a comprehensive strategy to address current and emerging insect pests and insecticide options in the Australian macadamia industry
Authors: Ellis Kirsten L , Anderson Jay M , Yonow Tania , Kriticos Darren J , Andrew Nigel R 
Published: February 2024

AbstractIn Australia, macadamia orchards are attacked by four main insect pest groups. Management and control of three of these key pests currently relies on broad‐spectrum insecticides whose long‐term future is questionable. Of the 23 insecticides registered for use in macadamia in Australia, 19 face issues affecting their availability and 12 are presently not approved in the EU, the USA or Canada. These international markets may refuse produce that does not adhere to their own insecticide use standards, hence Australian produce may be excluded from market access. Many of the potential replacement integrated pest management methods of pest control are generally considered less effective by the industry and have not been adopted. There are 17 insect pest groups identified by the industry, any of which have potential to become major problems if broad‐spectrum insecticide options become unavailable. Thirteen pest groups need urgent attention as they are at risk of losing current effective control methods, and no replacement solutions have yet been developed. The lag period for research and development to identify new chemical and biological control solutions means there is now an urgent need for the macadamia industry to craft a strategy for sustainable pest management for each pest. Critically, this industry strategy needs to address the vulnerabilities identified in this paper, identify potential solutions for any cases of market failure and consider funding mechanisms to address these gaps. On economic and sustainability grounds, potential biological control options should be explored, especially in cases where insecticide control options are vulnerable. © 2024 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Manipulated ants: inducing loyalty to sugar feeders with an alkaloid
Authors: Mogensen Anders Lander , Andersen Laurits Bundgaard , Sørensen Jesper Givskov , Offenberg Joachim 
Published: February 2024

AbstractBACKGROUNDWood ants are promising biocontrol agents in fruit plantations because they prey on pest insects and inhibit plant diseases. However, these ants also attend plant‐feeding homopterans to harvest their honeydew secretions, thereby increasing their numbers. This problem can be solved by offering ants alternative sugar sources that are more attractive than honeydew. From natural interactions, it is known that some species manipulate mutualistic partners toward loyalty by adding alkaloids to the food they offer their mutualists. Inspired by this, the addition of alkaloids might be used to make ants loyal to artificial sugar feeders and thus used to reduce populations of ant‐farmed homopterans in ant‐mediated biological control. We aimed to explore whether wood ants (Formica polyctena) would develop a taste preference for morphine‐containing sugar solutions in two‐choice laboratory tests.RESULTSAfter having fed on a morphine/sugar solution for 1 week, ants showed a significant preference for morphine solutions compared with equal concentration sugar solutions without morphine. Furthermore, ants lost this preference after 6–9 days on a morphine‐free diet.CONCLUSIONThe results show that wood ants react to morphine in their food, enabling chemical manipulation of their behavior, most likely through a taste preference. Thus, ants are susceptible to manipulation by mutualistic partners in natural interactions and furthermore may be manipulated artificially in biocontrol programs to avoid ant‐mediated build‐up of homopteran populations. © 2024 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
The emptiness at the heart of international law
Authors: Hulsroj Peter 
Published: February 2024

Abstract“What is not prohibited is allowed” is the principle at the heart of international law. Yet the principle is empty. It originates in the Lotus judgment of the Permanent Court of International Justice of 1927 where Turkey was allowed to prosecute a French citizen at the expense of the authority of France to have exclusive jurisdiction. This article recounts the history of “what is not prohibited is allowed” and explains where it has led us astray and where it is in the process of doing so. It recalls that the intention of the creators of the Permanent Court of International Justice was very different, namely that equitable balancing would take place when no specific international law norm could be identified. The article suggests how, through an Advisory Opinion by the International Court of Justice, equitable balancing can be re‐established as the fallback principle when international law is otherwise silent.
Ecology, status, and distribution of Temminck's pangolin (Smutsia temminckii) in Hwange National Park
Authors: Sabashau Kelly , Utete Beaven , Madlamoto Daphne , Ngwenya Nobesuthu , Madamombe Honest 
Published: February 2024

AbstractTemminck's pangolin, Smutsia temminckii (Smuts, 1832), faces conservation threats of poaching and trafficking in Zimbabwe. Using a mixed‐method approach we assessed the ecology, status, and distribution of Temminck's pangolin in Hwange National Park (HNP) over May–December 2021. Seven pangolins were recorded through direct sightings, although camera traps deployed did not detect pangolins. Biotic and abiotic factors including rainfall, air temperature, waterholes, digital elevation model, anthills, and Miombo vegetation influence pangolin distribution. The low pangolin numbers recorded in the study either indicate its shy nature or simply reflect its low densities in HNP. Short‐term surveys are inconclusive for determining key factors influencing the population, ecology, and distribution of shy species such as Temminck's pangolin. Long‐term future monitoring initiatives integrating ground surveys, citizen science data, and scientific methods like environmental DNA metabarcoding will enhance accurate assessment of pangolin population trends and presence inside and outside of protected areas such as HNP.
Negativity and its capacity in JT gravity
Authors: Okuyama Kazumi , Tachibana Takeshi 
Published: February 2024

Abstract
We study the refined Rényi negativity in the matrix model of Jackiw-Teitelboim (JT) gravity. We first consider the JT gravity with dynamical branes, which serves as a toy model of the evaporating black hole. By including the backreaction of branes, we find that the refined Rényi negativity monotonically decreases at late time of the evaporation. Next we define a novel quantity, which we call “capacity of negativity,” as a derivative of the refined Rényi negativity with respect to the replica number. We find that the capacity of negativity has two peaks as a function of time, which comes from the exchange of dominance of the different types of replica wormholes.
Renormalizing Love: tidal effects at the third post-Newtonian order
Authors: Mandal Manoj K. , Mastrolia Pierpaolo , Silva Hector O. , Patil Raj , Steinhoff Jan 
Published: February 2024

Abstract
We present the conservative effective two-body Hamiltonian at the third order in the post-Newtonian expansion with gravitoelectric quadrupolar dynamical tidal-interactions. Our derivation of the effective two-body Lagrangian is based on the diagrammatic effective field theory approach and it involves Feynman integrals up to three loops, which are evaluated within the dimensional regularization scheme. The elimination of the divergent terms occurring in the effective Lagrangian requires the addition of counterterms to ensure finite observables, thereby introducing a renormalization group flow to the post-adiabatic Love number. As a limiting case of the renormalized dynamical effective Hamiltonian, we also derive the effective Hamiltonian for adiabatic tides, and, in this regime, calculate the binding energy for a circular orbit, and the scattering angle in a hyperbolic scattering.
Bragg-Primakoff axion photoconversion in crystal detectors
Authors: Dent James B. , Dutta Bhaskar , Thompson Adrian 
Published: February 2024

Abstract
Axions and axion-like pseudoscalar particles with dimension-5 couplings to photons exhibit coherent Primakoff scattering with ordered crystals at keV energy scales, making for a natural detection technique in searches for solar axions. We find that there are large suppressive corrections, potentially greater than a factor of $$ \mathcal{O} $$
O
(103), to the coherent enhancement when taking into account absorption of the final state photon. This effect has already been accounted for in light-shining-through-wall experiments through the language of Darwin classical diffraction, but is missing from the literature in the context of solar axion searches that use a matrix element approach. We extend the treatment of the event rate with a heuristic description of absorption effects to bridge the gap between these two languages. Furthermore, we explore the Borrmann effect of anomalous absorption in lifting some of the event rate suppression by increasing the coherence length of the conversion. We study this phenomenon in Ge, NaI, and CsI crystal experiments and its impact on the projected sensitivities of SuperCDMS, LEGEND, and SABRE to the solar axion parameter space. Lastly, we comment on the reach of multi-tonne scale crystal detectors and strategies to maximize the discovery potential of experimental efforts in this vein.
Cardiovascular risk management among individuals with type 2 diabetes and severe mental illness: a cohort study
Authors: ter Braake Jonne G. , Fleetwood Kelly J. , Vos Rimke C. , Blackbourn Luke , McGurnaghan Stuart J. , Wild Sarah H. , Jackson Caroline A. ,   on behalf of the Scottish Diabetes Research Network Epidemiology Group
Published: February 2024

Abstract
Aims/hypothesis
The aim of this study was to compare cardiovascular risk management among people with type 2 diabetes according to severe mental illness (SMI) status.

Methods
We used linked electronic data to perform a retrospective cohort study of adults diagnosed with type 2 diabetes in Scotland between 2004 and 2020, ascertaining their history of SMI from hospital admission records. We compared total cholesterol, systolic BP and HbA1c target level achievement 1 year after diabetes diagnosis, and receipt of a statin prescription at diagnosis and 1 year thereafter, by SMI status using logistic regression, adjusting for sociodemographic factors and clinical history.

Results
We included 291,644 individuals with type 2 diabetes, of whom 1.0% had schizophrenia, 0.5% had bipolar disorder and 3.3% had major depression. People with SMI were less likely to achieve cholesterol targets, although this difference did not reach statistical significance for all disorders. However, people with SMI were more likely to achieve systolic BP targets compared to those without SMI, with effect estimates being largest for schizophrenia (men: adjusted OR 1.72; 95% CI 1.49, 1.98; women: OR 1.64; 95% CI 1.38, 1.96). HbA1c target achievement differed by SMI disorder and sex. Among people without previous CVD, statin prescribing was similar or better in those with vs those without SMI at diabetes diagnosis and 1 year later. In people with prior CVD, SMI was associated with lower odds of statin prescribing at diabetes diagnosis (schizophrenia: OR 0.54; 95% CI 0.43, 0.68, bipolar disorder: OR 0.75; 95% CI 0.56, 1.01, major depression: OR 0.92; 95% CI 0.83, 1.01), with this difference generally persisting 1 year later.

Conclusions/interpretation
We found disparities in cholesterol target achievement and statin prescribing by SMI status. This reinforces the importance of clinical review of statin prescribing for secondary prevention of CVD, particularly among people with SMI.

Graphical Abstract
Pure niobium manufactured by Laser-Based Powder Bed Fusion: influence of process parameters and supports on as-built surface quality
Authors: Candela Silvia , Rebesan Pietro , De Bortoli Diego , Carmignato Simone , Zanini Filippo , Candela Valentina , Dima Razvan , Pepato Adriano , Weinmann Markus , Bettini Paolo 
Published: February 2024

AbstractNiobium (Nb) is a transition metal commonly used as an alloying element for increasing strength, toughness, corrosion resistance, and other properties of steel and superalloys. Pure Nb, however, is a very interesting metal for its excellent superconductivity. This makes it suitable for producing superconducting magnets and devices for particle acceleration systems and particle physics research (e.g., superconducting resonant cavities). In this work, the production of Nb by the Laser-Based Powder Bed Fusion (PBF-LB/M, also known as Laser Powder Bed Fusion or LPBF) process was examined. Manufacturing parameters were investigated to achieve additively manufactured parts with a relative density higher than 99.5% and showing a down-skin surface roughness in the range of 20–70 μm, depending on the inclination angle. Studies related to the limiting angle of self-supported Nb parts were also conducted, and innovative non-contact supporting structures were successfully developed. These allowed to creation of parts with very small overhang angles, without compromising the downward-facing surfaces; indeed at the same time, the as-built surface finish was improved.