bluuebunny/crossref_metadata_2025_split huggingface dataset:
A new approach to cultural scripts of trauma sequelae assessment: The sample case of Switzerland
Authors: Bachem Rahel , Mazza Amelie , Eberle David J. , Maercker Andreas 
Published: April 2024

Background
The novel concept of cultural scripts of trauma sequelae captures culture-specific expressions of posttraumatic distress (e.g., cognitive, emotional, interpersonal, psychosomatic changes) and their temporal associations. Cultural scripts of trauma sequelae complement pan-cultural (etic) diagnoses, such as posttraumatic stress disorder (PTSD) and Complex PTSD, as well as the cultural syndromes concept.

Objective
This study aimed to develop the cultural scripts of trauma inventory (CSTI) for German-speaking Switzerland and to explore temporal associations of script elements.

Method
Five semi-structured focus groups were conducted with psychotraumatologists (n = 8) and Swiss trauma survivors (n = 7). The interview schedule included open questions about different domains of potential posttraumatic changes (emotions, cognitions, worldviews, interpersonal relationships, body-related experiences, behavior, and growth). Data were analyzed using qualitative content analysis.

Results
The Swiss CSTI includes 57 emic elements that represent salient trauma sequelae (30 conformed with a theoretically derived item pool, 27 were newly phrased). Temporal script associations were visualized in a network, whereby self-deprecation, the urge to function and overcompensate, and the urge to hide and endure suffering had the highest number of connections.

Conclusion
While many posttraumatic changes identified in the present work seem to mirror pan-cultural phenomena represented in the Complex PTSD concept (e.g., self-deprecation), others (e.g., urge to function and perform, urge to hide and endure suffering) may be prominently related to Swiss culture with its value orientations. Knowledge about cultural scripts of trauma sequelae may provide a culture-specific framework that can help to understand individual experiences of distress and enable mental health practitioners to administer culturally sensitive interventions. Pending further validation, the Swiss CSTI bears the potential to advance culture-sensitive assessment of trauma sequelae.
Effectiveness of the online-eLearning program KeepCoool at improving the vaccine cold chain in general practices
Authors: Thielmann Anika , Schmitz Marie-Therese , Welchowski Thomas , Weltermann Birgitta 
Published: April 2024

Background
Protecting vaccines from freeze damage is a poorly addressed problem. We describe the effectiveness of the eLearning KeepCoool on cold chain maintenance in general practices.

Methods
For this intervention study, temperatures of vaccine refrigerators were logged at one-minute intervals. Personnel from practices with cold chain breaches was offered the eLearning. The primary outcome was the intervention’s effectiveness to achieve temperatures in the target range (2 to 8°C) in the sixth week (follow-up) compared to the first (baseline). Using continuous temperature data, a generalized additive model for location, scale and shape was estimated.

Results
The practice response rate was 38% (64 of 168). At baseline, 73% of the practices and 68% of the refrigerators (51 of 75) showed cold chain breaches. 47% of the practices (n = 22 with 24 refrigerators) participated in the eLearning (55 physicians and practice assistants). At follow-up, 17% of those refrigerators were in the target range continuously, 38% reached targets 95% of the time while always >0°C, and temperatures ≤0°C decreased by 63%. Based on 2 million temperature data, the average Euclidian distance based on regression showed a significant improvement (p<0.05).

Conclusion
The eLearning KeepCoool improved the practices´ vaccine cold chain. It is freely available at https://keepcoool.ukbonn.de.
Associations of adupocutokine and metaboliv hormone level in young people aged 25-44 years with type 2 diabetes mellitus and abdominal obesity
Authors: Kashtanova E. V. , Polonskaya Ya. V. , Shcherbakova L. V. , Stakhneva E. M. , Shramko V. S. , Mustafina S. V. , Khudyakova A. D. , Ragino Yu. I. 
Published: April 2024

BACKGROUND: Diabetes mellitus and obesity are two closely related diseases that are a global public health problem. Obesity is characterized by an increase in the volume of adipose tissue and a change in the production and function of adipocytokines, which leads to a violation of the regulation of insulin sensitivity and glucose metabolism, contributing to the development of insulin resistance and diabetic pathology.AIM: The aim of this study was to evaluate the concentrations of individual adipocytokines and metabolic hormones in patients with DM2 and without diabetes, depending on the presence/absence of abdominal obesity (AO).MATERIALS AND METHODS: A single-center observational cross-sectional study was conducted. A population subsample of men and women aged 25–44 years was examined. Socio-demographic data were collected, anthropometric measurements were performed. The levels of amylin, C-peptide, ghrelin, glucose-dependent insulinotropic polypeptide, glucagon-like peptide 1 (GLP-1), glucagon, were determined in blood serum by multiplex analysis using a set of reagents Human Metabolic Hormone V3 (USA) and Human Adipokine Panel 1 (USA) on a Luminex MAGPIX flow fluorimeter (USA). interleukin 6, insulin, leptin, monocytic chemotactic factor 1 (MCP-1), pancreatic polypeptide (PP), peptide YY (PYY), tumor necrosis factor alpha (TNF-α), adiponectin, adipsin, lipocalin-2, plasminogen activator inhibitor-1 (PAI-1) and resistin.RESULTS: The study included 105 people. The main group consisted of 35 people with diabetes mellitus, 11 of them without AO and 24 with AO, the control group consisted of 70 people without diabetes mellitus (35 people with AO and 35 without AO), comparable in gender and age with the main group. In individuals with abdominal obesity, regardless of the presence of type 2 diabetes mellitus, the levels of C-peptide, GLP-1, insulin, leptin and TNF-alpha are higher than in individuals without abdominal obesity. The chance of having diabetes mellitus and AO is associated with an increase in leptin levels (OR=1.367, 95% CI: 1.050–1.779, p=0.020).CONCLUSION: The results of our study show that the indicators of the adipocytokine profile differ significantly in individuals with the presence/absence of abdominal obesity. According to our data, leptin makes the greatest contribution to the development of SD2 against the background of AO. Further research is needed to identify causal relationships and determine whether treatment that regulates adipocytokine levels can help in personalized approaches to the prevention and treatment of type 2 diabetes mellitus.
Androgen insensitivity syndrome: preventive gonadectomy, pros and cons
Authors: Starostina E. A. , Frolkova N. V. , Seidova S. M. , Przhiyalkovskaya E. G. , Platonova N. M. , Troshina E. A. 
Published: April 2024

Androgen insensitivity syndrome is a genetic disorder characterized by complete or partial androgen insensitivity in individuals with a 46XY genotype. It is also the most common cause of disorders of sexual differentiation in patients with a 46XY karyotype. This condition is caused by a defect in the androgen receptor gene (AR), leading to abnormal development of male genitalia, impaired formation of male secondary sexual characteristics, and phenotypic features resembling the female sex.One of the important aspects related to the management of androgen insensitivity syndrome is the necessity of preventive gonadectomy. However, the rationale for prophylactic removal of gonads remains a subject of debate. This article presents a clinical case of a 37-year-old woman with complete androgen insensitivity syndrome who, despite recommendations for gonadectomy based on suspicious MRI characteristics of the gonads, made the decision to decline surgical intervention, justifying her choice by the positive impact of gonadal hormonal activity on her external appearance and physical characteristics. This clinical case highlights the complexity of decision-making in the management of androgen insensitivity syndrome, where patient preferences and needs may play a significant role, despite potential risks and concerns surrounding the preservation of gonads.
Content of adipokines and myokines in the blood of children and adolescents with obesity with polymorphism of the gene of liver triacylglycerol lipase rs2070895
Authors: Shestopalov A. V. , Davydov V. V. , Tumanyan G. T. , Teplyakova E. D. , Shkurat T. P. , Mashkina E. V. , Shkurat M. A. , Gaponov A. M. , Borisenko O. V. , Roumiantsev S. A. 
Published: April 2024

BACKGROUND:A special role in the development of obesity is given to the genetic polymorphism of lipid metabolism enzymes, which include triacylglycerol lipase. However, there is still no information about the relationship between the single nucleotide polymorphism (snp) of the triacylglycerol lipase (LIPC) gene and the state of the endocrine function of mesenchymal tissues in childhood and adolescence obesity.AIM:The aim of the work was to study the relationship between snpLIPCfor rs2070895 and changes in the content of adipokines, myokines, and the values of blood lipid metabolism in obese children and adolescents with different sexes.MATERIALS AND METHODS:In 96 healthy children and adolescents of different sexes and 98 obese peers, a study was conducted to assess the snp of theLIPCby rs2070895. In the blood serum of the examined, the content of total cholesterol, HDL cholesterol, LDL cholesterol, VLDL cholesterol, triacylglycerols, glucose, activity of alanine aminotransferase and aspartate aminotransferase, as well as the level of leptin, adiponectin, resistin, apelin, irisin, adipsin, myostatin, FGF21, osteocrine, oncostatin M , insulin and asprosin.RESULTS AND DISCUSSION:It has been established that obesity in boys is accompanied by hyperleptinemia, the occurrence of insulin resistance and disorders of blood lipid metabolism. In carriers of the heterozygous allele -250G/A, dyslipidemia and atherogenesis decrease in obesity, but alteration of internal organs increases. In girls with differentLIPCgenotypes for rs2070895, with obesity, there is an increase in the level of leptin and apelin, as well as irisin and insulin in the blood. In girls with the homozygous allele -250G/G, in addition to that, the content of resistin, asprosin and prolactin decreases in the blood, which is not are typical for girls with the heterozygous allele -250G/A. In obese girls with the heterozygous allele, the levels of adipsin, FGF-21, oncostatin M, and osteocrine increase, which are not typical for obese girls with the homozygous allele. Against the background of changes in the content of adipokines and myokines in girls homozygous forLIPC, obesity occurs dyslipemia, which is not typical for girls with the heterozygous allele -250G/A.CONCLUSION:The snp ofLIPCat rs2070895 has sex-dependent effects on the levels of adipokines, myokines, and parameters lipid metabolism in the blood.
The 3% hypertonic saline infusion test for the differential diagnosis of diabetes insipidus and primary polydipsia: assessment of diagnostic accuracy
Authors: Katamadze N. N. , Pigarova E. A. , Dzeranova L. K. , Rebrova O. Yu. , Troshina E. A. 
Published: April 2024

AIM: assessment of the diagnostic accuracy of a 3% hypertonic saline infusion test in relation to a set of clinical and laboratory data (including a water deprivation test and MRI data) for differential diagnoses of diabetes insipidus (DI) and primary polydipsia (PP).METHODS: An interventional cross-sectional study was carried out at Endocrinology Research Centre From September 2021 to September 2023 ninety patients with polyuria-polydipsia syndrome were included. In order to assess the diagnostic characteristics, all the subjects underwent two tests with osmotic stimulation: a 3% hypertonic saline infusion test and a water deprivation test. Adverse events were assessed.RESULTS: Based on the results of clinical, anamnestic, laboratory and instrumental data, and the results of a water deprivation test, a final diagnosis of DI was made in 48 (53%) patients and PP in 42 (47%) patients. The agreement between the two samples is significant — Kappa = 0.823, 95% CI (0.707, 0.939). The operational parameters of the 3% hypertonic saline infusion test are: sensitivity 98% (95% CI: 89%; 100%); specificity 98% (95% CI: 87%; 100%), positive and negative predictive values 98% (95% CI: 89%–100%) and 98% (95% CI: 87%–100%). Respectively. Chills occurred significantly more often (31% vs. 12%), and dizziness and headache were more pronounced during the 3% hypertonic saline infusion test. The median duration of the water deprivation test in patients was 11 hours, and median duration of 3% hypertonic saline infusion test was 1.5 hour (P<0.001).CONCLUSION: The 3% hypertonic saline infusion test has a high overall diagnostic accuracy 98%; 95% CI 92% to 100%)) in relation to the classical set of clinical, laboratory and instrumental data of patients (including a water deprivation test), However, it is important the advantage of the latter is its short duration and, as a consequence, better tolerability and probably better compliance, while no significant differences in adverse events frequencies during the tests were identified.
Ethnomusicology, Folklore, and Social Relevance. By Josep Martí. Translated by Peter Collins
Authors: Josep Martí  , Peter Collins  
Published: April 2024

This article raises the need for (Spanish) ethnomusicology to replace rigid nineteenth century approaches with renewed anthropological and sociological concepts and analytical tools, Through the notion of “social relevance,” the author responds to this need and advocates for the study of horizontal influence (dynamic, meaningful), rather than vertical roots (ancestral, quasi-sacred) in a musical repertoire. “Social relevance” would be the academic opposite to “cultural paternity” (as ethnic ascription), prioritizing the importance that a song, instrument, or dance has for a community in a specific moment. Therefore, the main task of an ethnomusicologist is to understand the musical life of a society, because the relevance does not depend on music itself, but on its context. Consequently, the concept of social relevance rejects perceptions of popular music studies as marginal, and instead accepts the study of popular music as a discipline that deserves full scholarly attention, eliminating mythologized hierarchies of elite groups. The article discusses how social relevance manifests in three interrelated dimensions: meaning, or how a musical piece is perceived; the uses to which it is put; and its social functions. These analyses apply to different genres such as opera, jazz, rock, folk, classical, and avant-garde music, and point out the universal attributes they all share according to the principle of their social relevance.
Citation:
Originally published in Spanish as “Etnomusicología, folklore y relevancia social.” In Actas del I Congreso de la Sociedad Ibérica de Etnomusicología, edited by Jordi Raventós, 11-22. Barcelona: La mà de Guido, 1996.
Perbandingan Kualitas InaCORS dan SuGAr untuk Studi Pemantauan Deformasi Kerak di Sumatera
Authors: Alif Satrio Muhammad , Siregar Ribhan Nafiz , Siburian Yesica Tumim , Anggara Ongky 
Published: April 2024

Pemantauan deformasi kerak di Sumatera merupakan hal penting dalam pemahaman aktivitas tektonik dan potensi gempa bumi di wilayah tersebut. Tingginya aktivitas tektonik di Pulau Sumatera dapat dikuantifikasi dengan pengamatan stasiun kontinu. Penelitian ini membandingkan kualitas dua jaringan pengamatan stasiun kontinu yang tersedia di Pulau Sumatera yaitu Sumatran GPS Array (SuGAr) dan Indonesia Continuously Operating Reference Stations (InaCORS). Data stasiun kontinu yang digunakan, diamati dari 2020 hingga 2022, dan digunakan untuk menganalisis perubahan posisi permukaan dan deformasi kerak secara kontinu. Hasil perbandingan kedua jenis stasiun kontinu menunjukkan bahwa stasiun SuGAR dan stasiun InaCORS memiliki ketelitian yang baik dengan orde milimeter. Pada hasil komponen horizontal dan komponen vertikal, nilai ketelitian stasiun SuGAR lebih baik dibandingkan stasiun InaCORS. Kedua data merupakan sumber data yang penting untuk pemantauan deformasi kerak sehingga penggunaan kedua stasiun ini secara kombinasi dapat memberikan gambaran yang lebih komprehensif tentang pemantauan pergerakan deformasi kerak di Sumatera.
Aplikasi Tensor Fase Data Magnetotellurik untuk Pemodelan Panas Bumi The Geysers, California dan Dikorelasikan dengan Data Gaya Berat
Authors: Irawati Selvi Misnia , Paembonan Andri Yadi , Fernanda Leonardo 
Published: April 2024

Lapangan panas bumi The Geysers terletak di antara dua sesar strike-slip yang tidak aktif, yaitu Sesar Mercuryville dan Collayomi berarah barat laut tenggara. Bagian barat laut The Geysers merupakan lokasi proyek Enhanced Geothermal System (EGS), karena pada area ini lokasi zona reservoir memiliki suhu yang tinggi mencapai 400 °C dengan kedalaman sekitar 2,6 km di bawah permukaan. Penelitian ini bertujuan untuk mengetahui struktur dan kondisi bawah permukaan barat laut The Geysers menggunakan analisis tensor fase data magnetotellurik dan dikorelasikan dengan data gaya berat. Analisis tensor fase digunakan untuk mengetahui arah geoelectrical strike yang timbul akibat adanya ketidakhomogenan konduktivitas listrik secara lateral di Bumi dan memberikan informasi tentang kondisi bawah permukaan. Arah geoelectrical strike pada daerah penelitian diperoleh sekitar N145°E. Clay cap diidentifikasi memiliki nilai resistivitas <30 Ohm.m dengan kedalaman 0,2 km dan ketebalan 0,8 – 1 km, batupasir graywacke merupakan reservoir utama pada daerah penelitian memiliki nilai resistivitas 30 – 90 Ohm.m dengan kedalaman 1 km dan ketebalan 0,4 – 1,8 km, serta terdapat area yang lebih resistif dengan nilai resistivitas 90 – 300 Ohm.m pada kedalaman 1,5 – 2 km merupakan batuan metagraywacke. Peningkatan temperatur reservoir pada kedalaman 2,6 km diduga karena adanya peran dari batuan metagraywacke sebagai Hot Dry Rock Reservoir (HDR).
Revisiting the Authorship of [Arist.] περὶ πνεύματος: The Case for Theophrastus
Authors: Torrente Luca 
Published: April 2024

Abstract
In this article, I claim that the treatise known as περὶ πνεύματος/De spiritu (481a-486b Bekker) was written by Theophrastus. My overall argument unfolds in three stages: first, I briefly summarize the arguments against De spiritu’s authenticity in Aristotle’s corpus. This summary will lead to my first argument which uses the very same reasons that prove the non-Aristotelian authorship to claim the Theophrastean one, in particular linguistic aspects of the text (§2). Next, I will focus on chronology, by discussing the mention of one Aristogenes to show that Aristotle could not have known this individual (§3). Third and last, I will examine various aspects of the work that demonstrate stylistic and argumentative connections (§4), as well as doctrinal affinities with the works of Theophrastus, although some have attributed it to Strato (§5). On the basis of these arguments, I conclude that the weight of the evidence makes On Breath a work by Theophrastus (or his circle) rather than one composed by Aristotle.
Natural Death and Teleology in Aristotle’s Science of Living Beings
Authors: Zemolin Lorenzo 
Published: April 2024

Abstract
According to most interpreters, Aristotle explains death as the result of material processes of the body going against the nature of the living being. Yet, this description is incomplete, for it does not clarify the relationship between the process of decay and the teleological system in which it occurs: this makes it impossible to distinguish between natural and violent death. In this paper, I try to fill this gap by looking at his so-called ‘biological works’ and mainly at the De Juventute. I first introduce the specific concept of life at play in this treatise and prove its complementarity with the framework of the De Anima. Then, I illustrate in detail the process of dying and the reasons why a merely material description is insufficient to account for the distinction between natural and violent death. Finally, I show that for Aristotle natural death is a by-product of teleologically directed life activities: only against the background of this teleological structure is natural death fully explained in terms of essence and causes. To support this claim, I compare death to two analogous cases in Aristotle’s biology, namely dreams and the features of GA V.
Highly specific vaginal microbiome signature for gynecological cancers
Authors: Han Mengzhen , Wang Na , Han Wenjie , Liu Xiaolin , Sun Tao , Xu Junnan 
Published: April 2024

Abstract
To investigate the vaginal microbiota signature of patients with gynecologic cancer and evaluate its diagnostic biomarker potential. We incorporated vaginal 16S rRNA-seq data from 529 women and utilized VSEARCH to analyze the raw data. α-Diversity was evaluated utilizing the Chao1, Shannon, and Simpson indices, and β-diversity was evaluated through principal component analysis using Bray-Curtis distances. Linear discriminant analysis effect size (LEfSe) was utilized to determine species differences between groups. A bacterial co-abundance network was constructed utilizing Spearman correlation analysis. A random forest model of gynecologic tumor risk based on genus was constructed and validated to test its diagnostic efficacy. In gynecologic cancer patients, vaginal α-diversity was significantly greater than in controls, and vaginal β-diversity was significantly separated from that of controls; there was no correlation between these characteristics and menopause status among the subject women. Women diagnosed with gynecological cancer exhibited a reduction in the abundance of vaginal Firmicutes and Lactobacillus, while an increase was observed in the proportions of Bacteroidetes, Proteobacteria, Prevotella, Streptococcus, and Anaerococcus. A random forest model constructed based on 56 genus achieved high accuracy (area under the curve = 84.96%) in gynecological cancer risk prediction. Furthermore, there were discrepancies observed in the community complexity of co-abundance networks between gynecologic cancer patients and the control group. Our study provides evidence that women with gynecologic cancer have a unique vaginal flora structure and microorganisms may be involved in the gynecologic carcinogenesis process. A gynecological cancer risk prediction model based on characteristic genera has good diagnostic value.