bluuebunny/crossref_metadata_2025_split huggingface dataset:
Non-execution of Strasbourg Judgments against Russia: the Case for a Trust Fund
Authors: Koroteev Kirill 
Published: March 2024

Abstract
After being expelled from the Council of Europe, Russia passed a law on not complying with any judgment of the European Court of Human Rights that entered into force after 15 March 2022. In these circumstances, new approaches are required to safeguard the authority of the Court. This study considers the possible ways out of the deadlock. Firstly, it critically examines the Committee of Minister’ strategy on implementing Russian judgments, which is limited to registering outstanding obligations of the Russian Government under the Court’s judgments. Secondly, the frozen property in Europe is yet to be confiscated, nor it is clear whether it will be. This study proposes that, under the aegis and within a legal framework of an existing international organization, a trust fund be established which may receive voluntary contributions from States and individuals. It will be better placed to do so than multiple indigent individuals scattered across the globe. If and when Russia applies to return to the Council of Europe it may be required to reimburse, with all accrued interest, the amounts spent by such a trust fund.
Pushback or Backlash against the European Court of Human Rights?
Authors: Kubal Agnieszka , Mrowicki Marcin 
Published: March 2024

Abstract
This article uses the theoretical model of ‘pushback-backlash’ developed by Madsen, Cebulak and Wiebusch (2018) for a comparative analysis of the differing patterns of reaction to the European Court of Human Rights (ECtHR) by two Eastern European countries – Russia, and Poland. We argue that Russian Constitutional Court’s (RCC) rejection of ECtHR authority, while extraordinary and legislated by the Duma, was in fact self-limiting, as observed in politically motivated cases. The decisions of the Polish Constitutional Tribunal (PCT), by contrast, go further than pushback, as rights enshrined in the Convention may soon become illusory to Polish citizens. Having chosen a country that was expelled from the Convention (Russia), and one that is still a member (Poland), we suggest opening the conceptual binary between ‘pushback’ and ‘backlash’ towards a dynamic continuum.
Photogrammetry: Adding Another Dimension to Virtual Gross Pathology Teaching
Authors: Ricci Emanuele , Leeming Gail , Ressel Lorenzo 
Published: March 2024

Pathology is a discipline that relies on the description and interpretation of changes occurring in organs and tissues, and it is largely a “hands-on” experience, both during training and professional practice. Instigated by the need to provide a solution for online learning and teaching, a plethora of different approaches have been tested during the Covid-19 pandemic. The enforced inability to meet in person created the necessity to quickly replace the hands-on experience of practical classes, routinely considered the “gold standard” in undergraduate pathology teaching, with alternative and innovative digital solutions that could allow the students to appreciate most, if not all, features of the specimen to describe and interpret. Here we present a successful deployment of photogrammetry for the purpose of teaching gross veterinary pathology to undergraduate students. Fresh specimens obtained during routine diagnostic post-mortem activity have been photographed using Digital Single-Lens Reflex cameras and rendered into high quality 3D models, preserving almost unaltered morphology, color, and texture, when compared to the original specimen. Once processed using photogrammetry software, exported and uploaded into an online repository, 3D models become readily available via our digital learning platform (CANVAS) to all undergraduate students for self-study and consolidation, as well as to teaching staff for use during online lectures, traditional face-to-face classes, small group teaching and seminars. Preliminary data collected from students’ feedback highlighted the positive reception from users, and the enriched learning experience, while prolonging indefinitely the availability of rare and perishable teaching material.
“I Would Have My Children Participate IF …”: Perceptions of Canadian Caregivers Towards School Food Programs
Authors: Datta Gupta Suvadra , Muhajarine Nazeem , Engler-Stringer Rachel 
Published: March 2024

Purpose: The Canadian federal government has expressed an intention to work with provinces and territories to develop a national school food program (SFP). This study aimed to explore caregivers’ perception of attributes important to include in a future SFP. Methods: An online cross-sectional survey was conducted. Fifteen elementary schools from high, medium, or low median income neighbourhoods in Saskatoon were invited to participate. School principals sent a survey link to students’ caregivers. The 37-item survey included an item with 15 statements asking caregivers to rate the importance of various components of a SFP. Descriptive statistics and exploratory factor analysis were conducted. Results: A total of 510 caregivers completed the survey (response rate of 52%). The factor analysis indicated four key components of a future SFP: (1) learning opportunities on growing and preparing food, (2) offering healthy food following Canada’s Food Guide, (3) affordability of the meals offered, and (4) cultural adaptability of the meal program. Over 90% of caregivers thought providing healthy meals and ample time to eat meals to be very important. Conclusion: Our results indicate caregivers support multicomponent meal programs that, along with providing nutritious food, help children build healthy habits and sustainable food systems. These findings will help dietitians understand caregivers’ perspectives to inform the design of a national SFP.
Incorporating Nigella sativa nanoemulsion into gelatin-guar gum films for enhanced healing of wound infections
Authors: Mutlu Neslihan 
Published: March 2024

Aim: This study aims to investigate the impact of incorporating Nigella sativa essential oil nanoemulsion (NSNE) into gelatin (Ge) and guar gum (GG)-based films at various concentrations (0%, 2%, 4%, and 6%) and to evaluate the antimicrobial properties of the resulting films against common bacterial strains associated with wound infections.
Methods: The nanoemulsion (NE) was obtained through ultrasonic irradiation. Polydispersity index, zeta potential, and particle size of NE were measured. For film preparation, gelatin (Ge) and guar gum (GG) were used, incorporating NSNE at concentrations of 0%, 2%, 4%, and 6%. Mechanical properties were evaluated using an universal testing machine, film thickness with a micrometer, and crystalline structure through XRD analysis. SEM was utilized for microstructure examination, and hydrophobicity was assessed by contact angle measurements. Antimicrobial activity was determined via the disk diffusion method against bacteria relevant to wound infections. Statistical analysis employed one-way ANOVA and Tukey post hoc tests with a significance level set at 5%.
Results: The particle size, polydispersity index (PDI), and zeta potential of the nanoemulsion were measured as 296±4.85 nm, 0.569±0.2, and -35.2±07 mV, respectively. The incorporation of NSNE into GE-GG-based films demonstrated promising antimicrobial efficacy against common wound infection bacteria, including Escherichia coli, Pseudomonas aeruginosa, Enterococcus faecalis, Staphylococcus aureus, and Klebsiella pneumoniae. The films maintained mechanical integrity, with no significant alterations in tensile strength (TS) and elongation at break (EAB) (p  0.05). However, higher NSNE concentrations led to decreased hydrophobicity (p < 0.05) and structural changes, as evidenced by increased pores and cracks observed in SEM images.
Conclusion: This study highlight the potential of NSNE-containing films for wound healing applications, combining antimicrobial properties with a biocompatible film matrix.
PENGENDALIAN PERSEDIAAN BAHAN BAKU ROTAN MENGGUNAKAN METODE EOQ DAN POQ
Authors: Rifki Alfarizi  , Lubis Fitriani Surayya , Nazaruddin  , Nofirza  , Muhammad Rizki  
Published: March 2024

Persediaan persediaan bahan baku perlu dilakukan untuk meminimalkan biaya penyimpanan dan pemesanan bahan baku. UMKM Sekar Sari Perawang merupakan sebuah perusahaan industri yang kegiatan utamanya adalah memproduksi keranjang rotan. Permasalahan yang sering terjadi pada saat proses produksi adalah bahan baku yang tersedia di gudang tidak sesuai dengan kebutuhan produksi. Economic Order Quantity (EOQ) digunakan untuk menentukan kuantitas pesanan persediaan yang dapat meminimalkan biaya penyimpanan dan biaya pemesanan persediaan. Period Order Quantity (POQ) digunakan untuk menghemat total biaya persediaan dengan menekankan pada efektifitas frekuensi pemesanan agar lebih terpola. Tujuan dari penelitian ini untuk menganalisis biaya persediaan rotan pada perhitungan EOQ dan POQ serta menentukan sistem pengendalian persediaan pada perhitungan EOQ dan POQ untuk menjamin terdapatnya persediaan material rotan pada tingkat yang optimal di UMKM Sekar Sari Perawang. Hasil penelitian menunjukkan bahwa biaya persediaan menggunakan metode EOQ dapat menghemat biaya sebesar 27,9%, sedangkan metode POQ dapat menghemat biaya sebesar 11%. UMKM Sekar Sari Perawang harus melakukan Safety Stock sebanyak 1,1 batang dan melakukan pemesanan kembali minimal persediaan rotan tersisa sebanyak 111 batang.
Köztaurusz a 21. században?
Authors: Bódog András 
Published: March 2024

Magyarországon a Köztaurusz elnevezésű általános információkereső tezaurusz szolgál a nemzeti könyvtárban, illetve a közkönyvtárakban gyűjtött dokumentumok tárgyszavazására. A tárgyszórendszerként is szolgáló tezaurusz évtizedeken át épült, jelenleg is folyamatosan gyarapodik a tárgyszójegyzék, ám mára már hatályon kívül helyezett szabványok figyelembe vételével készült. A tanulmány azt vizsgálja, hogy a Köztaurusz mennyire felel meg a hatályos nemzetközi (ISO) tezauruszszabványnak. Mivel a Köztaurusz alapvető fontosságú az Országos Széchényi Könyvtár és számos közkönyvtár mindennapi munkájában és szabványos tartalmi feltárásában, a rendszer mindenkori szabványossága elengedhetetlen annak továbbfejlesztése érdekében. A Köztaurusz modernizálásának és a kor kihívásainak megfelelő szinten tartásának legelső lépése ez a szabványossági vizsgálat.
Tumor Microenvironment in Colorectal Cancer Development: A Review of 3D Study Analysis
Authors: Angka Rebecca Noerjani , Sudoyo Aru Wisaksono , Siregar Nurjati Chairani , Jeo Wifanto Saditya , Antarianto Radiana Dhewayani 
Published: March 2024

Background: Colorectal cancer is the third most common cancer in 2020, with a high mortality rate. Colorectal cancer treatment has made many advances. However, many factors in the tumor microenvironment still have not been reached but significantly affect the success of treatment. This literature review was conducted to search for research articles that analyze factors in the tumor microenvironment, how they interact through studies primarily conducted in 3D, and how to prepare for 3D research on colorectal cancer will be briefly discussed. The aim of this systematic review is to study the components of the tumor microenvironment in colorectal cancer development as assessed by 3D studies. Methods: Article searches were conducted through Embase, Scopus and PubMed. From the 110 articles found at the beginning of the search, after going through several screening stages, 27 articles were determined that met the inclusion criteria. The inclusion criteria used were journals containing research articles on colorectal cancer in the last five years with topics regarding the tumor microenvironment and according to keywords. Results: Microenvironment components in colorectal cancer, consisting of cellular and noncellular components, have the most significant effect on cancer development and ultimately affect metastasis, response to treatment, and prognosis. Conclusions: This literature review proves that the components of the tumor microenvironment are very diverse, making colorectal cancer heterogeneous. It still requires a lot of research to prove the existence of other components that affect the effectiveness of the treatment.
Levofloxacin loaded poly (ethylene oxide)-chitosan/quercetin loaded poly (D,L-lactide-co-glycolide) core-shell electrospun nanofibers for burn wound healing
Authors: Monavari Mahshid , Sohrabi Razieh , Motasadizadeh Hamidreza , Monavari Mehran , Fatahi Yousef , Ejarestaghi Negin Mousavi , Fuentes-Chandia Miguel , Leal-Egaña Aldo , Akrami Mohammad , Homaeigohar Shahin 
Published: March 2024

This study developed a new burn wound dressing based on core-shell nanofibers that co-deliver antibiotic and antioxidant drugs. For this purpose, poly(ethylene oxide) (PEO)-chitosan (CS)/poly(D,L-lactide-co-glycolide) (PLGA) core-shell nanofibers were fabricated through co-axial electrospinning technique. Antibiotic levofloxacin (LEV) and antioxidant quercetin (QS) were incorporated into the core and shell parts of PEO-CS/PLGA nanofibers, respectively. The drugs could bond to the polymer chains through hydrogen bonding, leading to their steady release for 168 h. An in vitro drug release study showed a burst effect followed by sustained release of LEV and QS from the nanofibers due to the Fickian diffusion. The NIH 3T3 fibroblast cell viability of the drug loaded core-shell nanofibers was comparable to that in the control (tissue culture polystyrene) implying biocompatibility of the nanofibers and their cell supportive role. However, there was no significant difference in cell viability between the drug loaded and drug free core-shell nanofibers. According to in vivo experiments, PEO-CS-LEV/PLGA-QS core-shell nanofibers could accelerate the healing process of a burn wound compared to a sterile gauze. Thanks to the synergistic therapeutic effect of LEV and QS, a significantly higher wound closure rate was recorded for the drug loaded core-shell nanofibrous dressing than the drug free nanofibers and control. Conclusively, PEO-CS-LEV/PLGA-QS core-shell nanofibers were shown to be a promising wound healing material that could drive the healing cascade through local co-delivery of LEV and QS to burn wounds.
New findings on CD16brightCD62Ldim neutrophil subtypes in sepsis-associated ARDS: an observational clinical study
Authors: Zhang Jing , Gao Chencheng , Zhu Zhenxing , Li Danyang , Qu Lai , Xue Qiuli , Wang Guoqiang , Ji Tong , Wang Fang 
Published: March 2024

BackgroundThe CD16brightCD62Ldim neutrophil subtype is a recently identified neutrophil subtype. The aim of this study was to evaluate changes of peripheral blood CD16brightCD62Ldim neutrophils in patients with sepsis-associated ARDS.MethodsWe prospectively recruited adult patients with sepsis-associated ARDS in the intensive care unit (ICU). Patient demographic data, medical history information, and laboratory data were collected within 48 hours of enrollment, and flow cytometry was applied to analyze the CD16brightCD62Ldim neutrophil subtype in the patients’ peripheral blood. Multifactor COX regression models were used to analyze factors affecting prognosis, and Spearman correlation coefficients were used to analyze clinical and laboratory indicators affecting complications of infection.ResultsOf the 40 patients, 9 patients died by the 28-day follow-up, indicating a mortality rate of 22.5%. Patients in the nonsurvival group had higher CD16brightCD62Ldim neutrophil levels. Patients with sepsis-associated ARDS who had a baseline proportion of CD16brightCD62Ldim neutrophil subtypes to total neutrophils in peripheral blood &gt;3.73% had significantly higher 28-day mortality, while patients with CD16brightCD62Ldim neutrophil subtypes counts &gt;2.62×109/L were also associated with significantly higher 28-day mortality. The percentage of the CD16brightCD62Ldim neutrophil subtype (HR=5.305, 95% CI 1.986-14.165, p=0.001) and IL-8 (HR=3.852, 95% CI 1.561-9.508, p=0.003) were independent risk factors for the development of infectious complications in patients with sepsis-related ARDS. The percentage of CD16brightCD62Ldim neutrophil subtypes predicted an AUC of 0.806 (95% CI 0.147-0.964, P=0.003) for the development of infectious complications, and 0.742 (95% CI 0.589-0.895, P=0.029) for the prediction of death within 28 days.ConclusionWe identified for the first time that CD16brightCD62Ldim neutrophils are elevated in patients with sepsis-associated ARDS and are associated with infectious complications and poor prognosis. The percentage of CD16brightCD62Ldim neutrophil subtypes may serve as a predictor of the development of infectious complications in patients with ARDS.
Rate of severe and fatal infections in a cohort of patients with interstitial lung disease associated with rheumatoid arthritis: a multicenter prospective study
Authors: Mena-Vázquez Natalia , Redondo-Rodriguez Rocío , Rojas-Gimenez Marta , Romero-Barco Carmen María , Fuego-Varela Clara , Perez-Gómez Nair , Añón-Oñate Isabel , Castro Pérez Patricia , García-Studer Aimara , Hidalgo-Conde Ana , Arnedo Díez de los Ríos Rocío , Cabrera-César Eva , Velloso-Feijoo Maria Luisa , Manrique-Arija Sara , Calvo-Gutiérrez Jerusalem , Gandía-Martínez Myriam , Morales-Garrido Pilar , Godoy-Navarrete Francisco Javier , Mouriño-Rodriguez Coral , Espildora Francisco , Aguilar-Hurtado María Carmen , Fernández-Nebro Antonio 
Published: March 2024

ObjectiveTo describe severe infection, foci of infection, microorganisms, associated factors, and impact on mortality in patients with rheumatoid arthritis–associated interstitial lung disease (RA-ILD).Patients and methodsThe study was based on a multicenter prospective cohort of patients with RA-ILD followed up from 2015 to 2023. The main outcome measures were incident severe infection and fatal infection. We evaluated infectious foci, etiologic agents, vaccination status, variables associated with lung function, and clinical-therapeutic variables in RA. The incidence rate (IR) for infection and mortality was calculated per 100 person-years, and 3 multivariate models were constructed to explore factors associated with infection.ResultsWe followed up 148 patients with RA-ILD for a median 56.7 months (699.3 person-years). During this period, 142 patients (96%) had at least 1 infection. A total of 368 infectious episodes were recorded, with an IR of 52.6 per 100 person-years. Of the 48 patients who died, 65% did so from infection. Respiratory infections were the most common first infection (74%), infection overall (74%), and fatal infection (80%) and were caused mostly by SARS CoV-2, Streptococcus pneumoniae, Pseudomonas aeruginosa, and influenza A virus. The factors associated with an increased risk of infection and death in patients with RA-ILD were age, inflammatory activity, and therapy with corticosteroids and immunosuppressants.ConclusionPatients with RA-ILD have a high risk of serious infection, especially respiratory infection. Infection develops early, is recurrent, and is frequently fatal. The presence of associated factors such as advanced age, joint inflammation, and treatment highlight the importance of integrated and preventive medical care.
Co-design of a paediatric oncology medicines database (ProCure) to support complex care provision for children with a hard-to-treat cancer
Authors: Mazariego Carolyn G. , McKay Skye , Tyedmers Elijah , Kelada Lauren , McGill Brittany C. , Daly Rebecca , Wakefield Claire E. , Ziegler David S. , Taylor Natalie 
Published: March 2024

ObjectivesPaediatric oncologists often encounter challenges when seeking compassionate access to off-label therapies for their patients. This study employed implementation science and co-design techniques to develop the ProCure medicines database, with the goal of streamlining the application process and addressing identified barriers in paediatric oncology.MethodsThis study utilised an exploratory qualitative research design. Seventeen healthcare providers, including oncologists, nurse consultants, and allied health professionals, participated in semi-structured interviews guided by the Consolidated Framework for Implementation Research (CFIR) and a visual process map aid. Deductive qualitative data analysis, according to the CFIR constructs, identified key barriers and facilitators. Collaborative design sessions engaged multidisciplinary teams to develop the ProCure beta version.ResultsBarriers to off-label therapy access included resource-intensive applications, time sensitive decision-making, and complex pharmaceutical information. Facilitators included Drug Access Navigators, Molecular Tumour Boards, and a multi-disciplinary approach. ProCure addressed end-user needs by centralising medicines information. Additional features suggested by healthcare providers included blood–brain-barrier penetrability data and successful application examples.ConclusionProCure represents a promising solution to the challenges paediatric oncologists face in accessing off-label therapies. By centralising information, it simplifies the application process, aids decision-making, and promotes a collaborative approach to patient care. The potential of the database to stream and enhance off-label therapy access underscores its relevance in improving paediatric oncology practise. Further research and implementation efforts are warranted to assess ProCure’s real-world impact and refine its features based on user feedback.
Assessing the cognitive decline of people in the spectrum of AD by monitoring their activities of daily living in an IoT-enabled smart home environment: a cross-sectional pilot study
Authors: Grammatikopoulou Margarita , Lazarou Ioulietta , Alepopoulos Vasilis , Mpaltadoros Lampros , Oikonomou Vangelis P. , Stavropoulos Thanos G. , Nikolopoulos Spiros , Kompatsiaris Ioannis , Tsolaki Magda 
Published: March 2024

IntroductionAssessing functional decline related to activities of daily living (ADLs) is deemed significant for the early diagnosis of dementia. As current assessment methods for ADLs often lack the ability to capture subtle changes, technology-based approaches are perceived as advantageous. Specifically, digital biomarkers are emerging, offering a promising avenue for research, as they allow unobtrusive and objective monitoring.MethodsA study was conducted with the involvement of 36 participants assigned to three known groups (Healthy Controls, participants with Subjective Cognitive Decline and participants with Mild Cognitive Impairment). Participants visited the CERTH-IT Smart Home, an environment that simulates a fully functional residence, and were asked to follow a protocol describing different ADL Tasks (namely Task 1 – Meal, Task 2 – Beverage and Task 3 – Snack Preparation). By utilizing data from fixed in-home sensors installed in the Smart Home, the identification of the performed Tasks and their derived features was explored through the developed CARL platform. Furthermore, differences between groups were investigated. Finally, overall feasibility and study satisfaction were evaluated.ResultsThe composition of the ADLs was attainable, and differentiation among the HC group compared to the SCD and the MCI groups considering the feature “Activity Duration” in Task 1 – Meal Preparation was possible, while no difference could be noted between the SCD and the MCI groups.DiscussionThis ecologically valid study was determined as feasible, with participants expressing positive feedback. The findings additionally reinforce the interest and need to include people in preclinical stages of dementia in research to further evolve and develop clinically relevant digital biomarkers.