bluuebunny/crossref_metadata_2025_split huggingface dataset:
Results of surgical treatment of pulmonary metastases
Authors: Shimizu Junzo , Oda Makoto , Hayashi Yoshinobu , Morita Katsuya , Arano Yoshihiko , Matsumoto Isao , Go Tetsuhiko , Murakami Shinya , Watanabe Yoh 
Published: February 2007

AbstractFrom 1970 to 1993, 155 thoracotomies for metastatic lung tumors were performed on 113 patients in the Department of Surgery, Kanazawa University School of Medicine. Overall 30‐day mortality amounted to 0.9% (1/113). The cumulative 3‐ and 5‐year survival rates were 39.4% and 29.1%, respectively. The overall median survival was 24 months. The 5‐year survival rate for carcinoma was 37.2% and for sarcoma it was 14.5% (P < 0.01). The other significant predictors of better long‐term survival with metastatic lung tumors were solitary lesions, disease‐free interval (DFI) > 24 months, and tumor size ≤ 20 mm in diameter. There was no significant difference in survival based on the method of pulmonary resection. Repeat thoracotomy for recurrent metastases was performed in 27 patients, whose 5‐year survival rate after the first lung resection was 35.5%. For bilateral pulmonary metastases, we recently performed simultaneous bilateral thoracotomy via median sternotomy on 25 patients and transsternal simultaneous bilateral thoracotomy on 8 patients. The latter procedure provides a wide operative field and better survival. We conclude that resection of metastatic lung tumors is safe and effective, and that repeat thoracotomy is warranted in selected patients with recurrent pulmonary metastases. © 1995 Wiley‐Liss, Inc.
Incidence and management of major urinary complications after pelvic exenteration for gynecological malignancies
Authors: Bladou Franck , Houvenaeghel Gilles , Delpéro Jean‐Robert , Guérinel Gérard 
Published: February 2007

AbstractUrinary fistulae and obstruction following pelvic exenteration are frequent and life‐threatening complications. They increase the mortality and morbidity rates of large exereses performed during pelvic exenteration for gynecological cancers. From a series of 97 patients who underwent pelvic exenteration for gynecological cancers we report the incidence, risk factors, and management of major urinary complications. Eighty patients had had previous surgery and/or pelvic radiation therapy at the time of pelvic exenteration. A urinary diversion was performed in 63 patients. Major early urinary complications were: urinary fistula in seven patients and ureteral obstruction in four patients (11.3% of the patients). Ten patients had a late urinary complication: stenosis of the cutaneous ureteral meatus (five), stenosis of the ureteroileal anastomosis following ileal loop (two), and urinary fistulae (three). Cancer recurrence was found in 4 of these 10 cases. Major early urinary complications were significantly increased in patients who had received previous pelvic radiation therapy (P < 0.05) and in patients who had had an intestinal conduit for urinary diversion (P < 0.05). Reoperation was done in six of seven cases of early urinary fistula (urinary undiversion four, nephrectomy one, ureteral reimplantation one). Three of four ureteral obstructions were managed with percutaneous nephrostomy and ureteral stent.We recommend the use of nonirradiated bowel segment for urinary diversion as transverse colon or jejunal conduit in patients who have received previous high doses of pelvic radiotherapy. For the management of urinary complications post pelvic exenteration, reoperation is required for most urinary fistula but ureteral obstructions can be managed with percutaneous nephrostomy and ureteral stent. © 1995 Wiley‐Liss, Inc.
Neural cell adhesion molecule and perineural invasion in gallbladder cancer
Authors: Seki Hitoshi , Koyama Kenji , Tanaka Jun‐Ichi , Sato Yasuhiko , Umezawa Akiko 
Published: February 2007

AbstractTo clarify the role of neural cell adhesion molecule (NCAM) in perineural invasion, NCAM expression was studied by immunohistochemical staining in 26 cases with gallbladder cancer. In gallbladder cancer, the incidence of perineural invasion and that of positive NCAM expression was 42% and 31%, respectively, which are less frequent than those of bile duct cancer in our previous report. Perineural invasion was observed in 88% of the patients with positive expression of NCAM and in 22% of those with negative expression. The former is similar to that of bile duct cancer but the latter is significantly lower. Eighty percent of the cancer cells that invaded the perineural space were positive for NCAM, when the primary tumor was positive for NCAM expression. Therefore, in gallbladder cancer, positive cells in NCAM expression likely invade the perineural spaces. However, the perineural invasion of negative cells in NCAM expression is not likely to occur as compared to bile duct cancer.In conclusion, perineural invasion in gallbladder cancer is not as common as in bile duct cancer, but the role of NCAM in perineural invasion is more important in gallbladder cancer than in bile duct cancer. © 1995 Wiley‐Liss, Inc.
Effects of doxorubicin on cancer cells after two‐thirds hepatectomy in rats
Authors: Ikeda Yasuharu , Matsumata Takashi , Utsunomiya Tohru , Yamagata Motoyuki , Takenaka Kenji , Sugimachi Keizo , Karakousis Constantine P. 
Published: February 2007

AbstractA rat model of liver metastases generated by intraportal injection of syngeneic tumor cells after two‐thirds hepatectomy was used to determine the optimal regional chemotherapeutic modality for early hepatic metastases. WKA rats had viable tumor cells injected directly into the portal vein after two‐thirds hepatectomy. Ten rats were used as a control; the remaining groups were given doxorubicin (4/3 mg/kg) injected directly into the hepatic artery at 24 hr, 72 hr, and 7 days (after liver regeneration) postoperatively. The mean survival period in each group was 21.0, 20.0, 20.5, and 20.7 days, respectively, compared with those treated with doxorubicin (4 mg/kg) injection at 24 hr, 72 hr, and 7 days postoperatively, with a mean survival period in each group of 20.0, 21.6, and 25.6 days, respectively. When a comparison was made with regard to the doses of doxorubicin administered, statistically significant differences in survival rates were recognized between the rats that had doxorubicin (4 mg/kg) injection 7 days postoperatively and the others (P < 0.01). Based on these findings, we believe that appropriate adjuvant chemotherapy should be given after the liver regeneration phase. © 1995 Wiley‐Liss, Inc.
Pancreatic cancer treatment in the U.S. veteran from 1987 to 1991: Effect of tumor stage on survival
Authors: Wade Terence P. , Kraybill William G. , Virgo Katherine S. , Johnson Frank E. 
Published: February 2007

AbstractTo assess the outcomes after pancreatic cancer treatment in a nationwide hospital system, patients treated in Department of Veterans Affairs (DVA) hospitals from 1987 to 1991 were studied by tumor stage, the most significant reported influence on survival. Tumor registrars from DVA hospitals provided information that allowed TNM staging in 598 patients, and duration of survival from treatment to death was known in 96+% of cases.Survival was 9 months longer after 64 resections for stage I–II (localized) pancreatic cancer than after 149 other treatments (P < 0.05, ANOVA), but resection did not increase mean survival in 49 patients with stage III (lymph node metastases) disease. Twenty‐one patients with ampullary, duodenal, bile duct, or cystic cancers had a significantly increased survival at any stage. Percutaneous biliary intubation had inferior results to operative therapy at all stages, but this may be due to the selection of sicker patients for nonoperative therapies. © 1995 Wiley‐Liss, Inc.
Clinicopathologic study of patients with Borrmann type iv gastric carcinoma
Authors: Kitamura Kaoru , Beppu Richiko , Anai Hideaki , Ikejiri Koji , Yakabe Shigeru , Saku Motonori , Sugimachi Keizo 
Published: February 2007

AbstractBetween 1979 and 1993, 665 Japanese patients with advanced gastric cancer underwent surgery at our hospital. These patients were divided into two groups, consisting of 102 patients with Borrmann type IV carcinoma, and the remaining 563 patients with all other types of gastric carcinoma, which were then compared clinicopathologically.In the patients with Borrmann type IV carcinoma, 77.4% of the lesions demonstrated poorly differentiated adenocarcinoma, and 99 patients were classified as Stage III or IV. The resection rate was 87.2% (89/102) with only 39 curative operations despite the fact that 70 total gastrectomies were performed. The incidence of peritoneal dissemination (29.4%) and serosal invasion (97.0%) was significantly higher in these patients. Microscopic lymph node metastasis was positive in 86.5%. The 5‐year survival rate was 23.4% in the patients with a curative operation and 5.0% in those with a noncurative operation (p < 0.01). Peritoneal dissemination was most frequently noted in the recurrence patterns.We conclude that early detection and a curative operation are both essential to improve the prognosis of patients with Borrmann type IV gastric cancer. The addition of a potent postoperative chemotherapy regimen is also recommended. © 1995 Wiley‐Liss, Inc.
Treatment of pseudomyxoma peritonei in a geriatric patient population
Authors: Sullivan Mack H. , Sugarbaker Paul H. 
Published: February 2007

AbstractPseudomyxoma peritonei of appendiceal origin is a disease characterized by the progressive accumulation of mucus ascites within the abdomen and pelvis. Metastatic disease outside the peritoneal cavity is unusual. Gastrointestinal function is lost from external compression of stomach, small bowel, and large bowel. New surgical and regional chemotherapy treatments were used to provide palliation of two patients aged 88 and 85 years. The selection criteria and methodologies for treatment of geriatric patients with pseudomyxoma peritonei are presented. © 1995 Wiley‐Liss, Inc.
Comparison of nephrectomy and/or doxorubicin treatment in rabbit renal VX‐2 carcinoma
Authors: Gadeholt‐Göthlin Gro , Göthlin Jan H. 
Published: February 2007

AbstractTo compare survival after local intra‐arterial and intravenous administration of doxorubicin, VX‐2 carcinoma was implanted in one kidney of 48 rabbits. Treatments were given 9–14 days after tumor implantation. Survival after doxorubicin was significantly longer than the controls, whereas no difference was established between intra‐arterial or intravenous treatment. Overall only 9 of 32 doxorubicin‐treated rabbits were cured at autopsy after 18 months. It was assumed that circulating tumor cells from tumor implantation resulted in “primary” lung metastases. To kill circulating tumor cells intravenous doxorubicin was given immediately before implantation in 40 rabbits, followed by combinations of nephrectomy and doxorubicin. Doxorubicin without nephrectomy cured 8 of 16 rabbits, whereas doxorubicin combined with nephrectomy cured 4 of 16.Doxorubicin improved survival in responders, but likelihood of response was limited. Nephrectomy did not improve survival, most likely due to metastatic seeding at implantation. Intravenous doxorubicin immediately before did not prevent metastatic spread in connection with tumor implantation. © 1995 Wiley‐Liss, Inc.
Diagnostic accuracy and role of fine needle aspiration cytology in management of thyroid nodules
Authors: Agrawal Shefali 
Published: February 2007

AbstractThe diagnostic accuracy of fine needle aspiration cytology (FNAC) was evaluated in thyroid nodules in 100 consecutive cases, who subsequently underwent thyroidectomy between the years 1989–1991. FNAC as a diagnostic test for thyroid nodules demonstrated an accuracy of 90.9%, a sensitivity of 76.5%, a specificity of 95.9% with a false positivity of 2%, false negativity of 4%, positive and negative predictive values of 86.7% and 92.2%, respectively. A correct classification of the carcinoma type on the basis of FNAC was possible only in 69% patients. As a result, FNAC is the first line of investigation in most nontoxic nodular goiters and often the only procedure necessary to obtain an accurate diagnosis. However, it is recommended only as an adjunct to clinical judgment and is not intended to replace it. © 1995 Wiley‐Liss, Inc.
Lymph node cancer of the mediastinal or hilar region with an unknown primary site
Authors: Kohdono Satoshi , Ishida Teruyoshi , Fukuyama Yasuro , Hamatake Motoharo , Takenoyama Mitsuhiro , Tateishi Masahiro , Sugimachi Keizo 
Published: February 2007

AbstractWe herein report three cases of lymph node cancer of the mediastinal or hilar region, in which the primary sites could not be determined in spite of performing various systemic examinations. Two cases revealed a large cell anaplastic carcinoma in the mediastinal lymph node, while the other demonstrated a small cell carcinoma in the hilar lymph node. However, based on radiographic and pathological examinations, the primary sites could not be found in either the head and neck, lung, or abdominal organs. All cases underwent surgical resections for lymph node cancer, while two patients also received adjuvant therapy. Two patients experienced recurrence soon after treatment. Despite the rarity of this disease, lymph node cancer must always be kept in mind when an enlargement of either the mediastinal or hilar lymph node is detected in patients with an unknown primary site, and a poor prognosis is generally expected. © 1995 Wiley‐Liss, Inc.
Ex vivo activated memory t‐lymphocytes as adoptive cellular therapy of human soft‐tissue sarcoma targets with potentiation by Cis‐diamminedichloroplatinum (II)
Authors: Gold Jay E. , Masters Ted R. , Bloom Norman D. , Shafir Michail K. , Klein Michael J. , Kenan Samuel , Osband Michael E. 
Published: February 2007

AbstractAutolymphocyte therapy (ALT) is tumor‐specific, adoptive cellular therapy of neoplastic disease using nonspecific ex vivo activation of autologous peripheral blood lymphocytes (PBL), which are composed primarily of memory T‐cells (ALT‐cells) and are active in patients with metastatic renal cell carcinoma and melanoma. Ex vivo pretreatment of tumor target cells with certain chemotherapeutic agents can enhance susceptibility to lysis by antitumor lymphocytes. To determine if cis‐diamminedichloro‐platinum(II) (CDDP) enhances ex vivo antitumor cytotoxicity of ALT‐cells and if this lysis is mediated by T‐ and/or NK‐cells and is human leukocyte antigen (HLA)‐restricted, human soft tissue sarcoma (STS) target cells were derived from primary and metastatic surgical specimens and were incubated with and without CDDP. ALT‐cells were prepared from autologous PBL obtained prior to surgery. Primary (PSTS) and metastatic (MSTS) target cells from each group were labelled with chromium 51 (51Cr) and used as targets for ALT‐cells, CD45‐depleted ALT‐cells, CD56 (NK)‐depleted ALT‐cells, and PBL in a standard (4‐hour) and delayed (18‐hour) 51Cr) release assay. Interferon‐gamma (IFN‐γ) release was measured as an indication of antitumor effect and recognition by the noncytolytic lymphocytes in ALT‐cells. Primary tumor target cells incubated in CDDP showed enhanced lysis as measured by the 51Cr release assay compared to non‐CDDP‐treated controls. Metastatic tumor target cells showed less lysis than the primary targets, although this was enhanced by pretreating metastatic tumor targets with CDDP. Lysis of all tumor targets was significantly greater when ALT‐cells were used as the effector cells rather than PBL. Depletion of memory T‐cells abrogated ex vivo lysis. Depletion of NK cells (CD56+) affected ex vivo lysis of autologous targets during the 4‐hour but not the 18‐hour assay. Ex vivo ALT‐cell lysis and IFN‐γ release against only the autologous tumor targets confirmed tumor specificity in one patient. Restriction of ALT‐cell lysis and IFN‐γ release against HLA‐A2+ autologous and one allogeneic HLA‐A2+ STS tumor target, but not other non‐STS targets, was demonstrated in another patient. These data suggest that CDDP may help render STS susceptible to tumorspecific, immune‐mediated attack and that the combination of ALT and CDDP may lead to effective tumor‐specific chemoimmunotherapy in patients with metastatic STS. © 1995 Wiley‐Liss, Inc.
Use of ileal urinary diversion in conjunction with intraoperative radiotherapy
Authors: Slaton Joel W. , Kropp Kenneth A. , Selman Steven H. , Merrick Hollis W. , Dobelbower Ralph R. 
Published: February 2007

AbstractIntraoperative radiotherapy (IORT) was introduced in the 1970s as a new modality of cancer therapy. It has been especially useful after local irradiation or surgical failure. We report on the use of IORT in 13 patients with pelvic tumors requiring urinary diversion. All 13 were managed with ileal conduits. Despite the associated problems of prior abdominal procedures (11/13 patients), prior external beam radiation to the pelvis (11/13 patients), systemic chemotherapy (4/13 patients), and prolonged operative time (> 10 hours), perioperative mortality (1/13) and morbidity rates were low. We conclude that in cases of prior colonic resection and pelvic radiation, potentially irradiated ileum can be safely used for urinary diversion. © 1995 Wiley‐Liss, Inc.
Needle localization breast biopsy: A model for multidisciplinary quality assurance
Authors: Howe J. R. , Kraybill W. G. , Monsees B. , Destouet J. , Dehner L. P. , Seib J. 
Published: February 2007

AbstractAs part of the quality assurance role of the Cancer Committee at Barnes Hospital, an institutional audit of Needle Localization Breast Biopsy (NLBB) was performed. Mammographic, operative, and surgical pathology reports from 370 consecutive patients at our institution undergoing both mammography and needle localization biopsy over a 34‐month interval were reviewed. Carcinoma was diagnosed pathologically in 103 patients (28%), and 27% of these proved to be noninvasive. Sixteen patients were found to have histologic or clinical involvement of the axillary nodes; no patients with Tis lesions were found to have axillary nodal involvement. Of the patients, 73% were found to have either Stage 0 or Stage I disease, and 61% with an established malignancy had mastectomy (67% of patients with invasive carcinoma, 44% of those with carcinoma‐in‐situ), whereas 39% had some form of conservation therapy (33% of patients with invasive lesions, 56% of those with carcinoma‐in‐situ). Our results have been compared with other published studies, and important clinical indicators for evaluating the results of individual centers performing NLBB are discussed. It is concluded that NLBB is a safe and effective method of biopsying nonpalpable breast lesions, which allows for the identification of early stage breast carcinomas. In the present environment of concerns about the quality of care and costs, it is the responsibility of each center performing NLBB periodically to evaluate their results with this multidisciplinary procedure and to bring about change in those areas found to be deficient. © 1995 Wiley‐Liss, Inc.
Quantitative comparison of xenotransplantation of a human soft tissue sarcoma into the subcutaneous tissue of normal, postincision, and postincision plus indomethacin‐treated nude mice
Authors: Huang Peigen , Allam Ayman , Taghian Alphonse , Ruka Wlodzimierz , Freeman Jill , Duffy Michael , Suit Herman D. 
Published: February 2007

AbstractThe purpose of this study was to test the hypotheses that (1) surgical wounding can enhance the xenotransplantability of a human soft tissue sarcoma (HSTS26T) into subcutaneous (s.c.) tissue of nude mice, and (2) Indomethacin may reduce the xenotransplantability of this human tumor in the surgical wounding animal model by suppressing angiogenesis. The experimental method was to employ the quantitative transplantation assays (TD50, the number of tumor cells that, on average, would be expected to induce a tumor in 50% of the recipients). After an incisional wound (1.0‐1.2 cm long) was made on the right leg of each experimental mouse, tumor cells were inoculated into the surgical wound, or into the contralateral leg at 24 and 72 hr postincision, and in another group tumor cells were inoculated into the wound at 72 hr postincision, plus daily s.c. injection of indomethacin, 2 mg/kg body weight for 8 consecutive days in a separate experiment. Nonincisional mice received the same inoculation as the control groups. The TD50s of surgically wounded groups were 3.5‐10.7 times lower than that of the control groups. Significantly lower TD50 values were found in groups of cells inoculated into the surgical wound at 72 hr postincision (P < 0.05 or P < 0.01) and into the contralateral leg at 24 hr postincision (P=0.05). No significant difference was found between the TD50 values in mice that received cells inoculated at 72 hr postincision plus indomethacin treatment, and those with no wound controls. Our conclusion is that the surgical wound can enhance the xenotransplantability of HSTS26T in nude mice. Indomethacin can decrease this enhancing effect level similar to that in no‐wound controls and may prevent tumor recurrence in a surgical wound. © 1995 Wiley‐Liss, Inc.
Influence of lipiodolization on a cirrhotic liver
Authors: Nishizaki Takashi , Takenaka Kenji , Ikeda Toshihiko , Yoshida Kisaku , Sugimachi Keizo 
Published: February 2007

AbstractLipiodolization—selective regional cancer chemotherapy using Lipiodol plus an anticancer drug (LPD)—can prolong survival time of patients with an unresectable hepatocellular carcinoma (HCC). To enhance understanding of LPD's influence on the cirrhotic liver, we carried out related studies. Forty‐three cirrhotic patients with HCC were treated with LPD (epirubicin in a dose of 15–40 mg/m2 and Lipiodol of 0.02–0.25 ml/kg). Seven cirrhotic patients with HCC were subjected to hepatic angiography alone, and these subjects selected randomly served as controls. Among the 43 treated with LPD, 23 belonged to Child's class A, 15 to class B, and 5 to class C. Blood samples were taken before angiography (pre) and at 24 hours after angiography (post) from each patient. Post/pre ratio of the following parameters were compared between patients of the two groups: sGOT, sGPT, and LDH as a marker for hepatocyte injury; t. bilirubin and hepaplastin test (HPT) as hepatocyte function; alkaline phosphatase and γ‐GTP to examine bile duct injury; and serum hyaluronic acid level to determine an endothelial cell functions. Post/pre ratio of serum GOT, GPT, LDH levels, and HPT in patients treated with vs. without LPD were 1.32 ± 0.59 vs. 0.92 ± 0.09 (P < 0.001), 1.18 ± 0.43 vs. 0.88 ± 0.09 (P < 0.001), 1.11 ± 0.20 vs. 1.00 ± 0.07 (P < 0.05), and 0.95 ± 0.10 vs. 1.09 ± 0.12 (P < 0.01), respectively. There were no significant differences in post/pre LPD ratio of other parameters, rates of complications, and hospital stay after LPD for patients with Child's class A, B, and C. Hepatocytes are apparently the primary site of injury in cases of LPD. LPDs, using epirubicin in a dose of 15–40 mg/m2 and Lipiodol in a dose of 0.02–0.25 ml/kg, proved to be safe for cirrhotic patients with HCC. © 1995 Wiley‐Liss, Inc.
Family with nonmedullary thyroid neoplasms
Authors: Kobayashi Kaoru , Tanaka Yoshiyuki , Ishiguro Shingo , Mori Tohru , Shigemasa Chiaki , Mitani Yasuo 
Published: February 2007

AbstractThis report concerns a family in which papillary thyroid carcinoma appeared in the father and two daughters and follicular adenoma in a granddaughter. The father died of systemic metastasis of papillary thyroid carcinoma. The two daughters and glanddaughter felt well postoperatively. We speculate that some gene‐related factors might play an important role in familial occurrence of papillary thyroid carcinoma and follicular thyroid adenoma in the family. © 1995 Wiley‐Liss, Inc.