bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating The Correlation Between Prolonged Survival In Patients With Advanced HER2+ Breast Cancer And The Activity Of Regulatory T Cells.
Authors: Degirmenci Mustafa , Diniz Gulden , Kahraman Dudu Solakoğlu , Sahbazlar Mustafa , Koral Lokman , Varol Umut , Uslu Ruchan 
Published: March 2024

Abstract
Purpose
Trastuzumab is commonly utilized in the management of metastatic breast cancer. Our main goal was to examine the extended outcomes of patients experiencing a persistent positive response to trastuzumab treatment.
Methods
Between 1995 and 2012, a total of 98 patients diagnosed with inoperable, locally recurring or metastatic HER2-positive breast cancer were retrospectively analyzed at Ege University Hospital and Tepecik Training and Research Hospital. The clinical and pathological characteristics of the patients were assessed, and the associations between response rates, survival, and the immune profiles of tumor infiltrating lymphocytes were statistically evaluated.
Results
The average age of patients at the time of diagnosis was 50.1 ± 10.3 (ranging from 30 to 79) years. The mean follow-up period for all patients was 97.9 ± 53.8 months. Among the patients, complete response was observed in 24.5%, partial response in 61.2%, and stable disease in 8.2% of cases. The average progression-free survival was 50.3 ± 26.9 months (ranging from 1 to 163 months), and the average overall survival was 88.8 ± 59.4 months (ranging from 12 to 272 months). After analyzing all cases, it was found that patients who were younger (p = 0.006), exhibited higher CD3- positivity (p = 0.041), presented with higher FOXP3- positivity (p = 0.025), showed complete or at least partial response to treatment (p = 0.008), and experienced a prolonged response to trastuzumab treatment (p = 0.001) had longer survival.
Conclusions
Patients with HER2-positive breast cancer, who initially respond positively to palliative trastuzumab treatment, can achieve long-term tumor remission lasting for several years.
Numerical investigation on Cold-Formed Steel Structural Frame made with lipped channel column and beam elements subjected to Lateral Loading
Authors: Sozharaja S , Baskar Rajaram 
Published: March 2024

Abstract
This paper deals with the structural behaviour of a cold-formed steel (CFS) structural frame subjected to lateral loading. The study involves the investigation of structural behaviour via an experiment programme and numerical investigation conducted on a structural frame using a cold-formed channel section constructed in a steel factory. The structural frame comprised columns, beams, a base plate, and its connection​​​​​​​ The section for the column consisted of a back-to-back channel section positioned and cold-formed. Section used for columns provided with and without lips. The section used for the beam is provided with a single channel section with and without lips. The numerical investigation was conducted using a finite element analysis procedure with the FEA software ANSYS 16.2 workbench. Through these investigations, a parameter study was conducted. Some important influencing factors, such as load-carrying capacity, stiffness, and the load– deflection relationship, were evaluated and discussed. From the result analysis, the structural frame made with a lipped channel section experienced high load carrying capacity and high stiffness compared with the other models considered.
Resonance conditions of electrostatically levitated drops in microgravity
Authors: Zhang Peng , Zhang Yang , Zhong Hongen , He Huan , Yu Jianding , Zhong Qiu , Yang Liping 
Published: March 2024

Abstract
The oscillation of electrostatically levitated droplets is a crucial technique for measuring thermophysical properties at high temperatures. However, notable disparities in resonance conditions have been observed between microgravity and ground experiments. In this study, a finite element method has been developed to investigate the oscillation process of charged droplets excited by an electric field in microgravity. The fluid dynamics is solved coupling with the electric field by using ALE method. It reveals that resonance conditions of electrostatically levitated drops strongly depend on the net surface charge of the droplet. When a drop possesses a substantial amount of net surface charge, it resonates as the excitation frequency approaches droplet’s natural frequency f2. Conversely, for drops with a small amount of net surface charge, the mode-2 oscillation can be excited only when the excitation frequency is half of the mode-2 resonance frequency f2/2. The simulation results demonstrate excellent agreement with experimental observations in microgravity. Understanding resonance dependence on net surface charge not only provides valuable information for improving accuracy in measuring thermophysical properties of electrostatically levitated drops, but also contribute significantly to understanding nonlinear oscillations behavior of charged drops in electrohydrodynamics.
Research on the reuse path of the Third Front Construction Heritage’s stock space in China based on value assessment
Authors: Xu Liquan , Zhang Zhentian , Tan Gngyi , Yuan Lei 
Published: March 2024

Abstract
The third-front construction, an integral component of socialist urban and rural development during the initial three decades of the new China, has resulted in a significant surplus of unused stock space following four decades of contraction and progress. The exploration of its reuse value in the contemporary era holds immense theoretical and practical significance. By focusing on 113 factories and mines associated with third-front construction in Hubei Western, this study employs qualitative field research and statistical analysis to assess their layout and condition characteristics. The concept of 'smart shrinkage' is employed to summarise the reuse value of the stock space derived from third-front construction. In addition, the intrinsic and extrinsic value of the reuse value assessment system is evaluated through the implementation of the minimum cumulative resistance (MCR) model, network analysis, and cluster analysis. Finally, a proposed pathway for the reuse of the stock space derived from third-front construction is presented. The study revealed several key findings. ① The plants and mines associated with third-front construction in Hubei Western exhibit a signficant concentration in certain areas, while also displaying a dispersed layout on a smaller scale. These establishments rely on regional transportation infrastructure, thereby forming a corridor-like structure. However, due to the implementation of relocation policies, idleness and inefficiency have become prevalent issues. ② The reuse value of the stock space derived from third-front construction exhibits distinct typological characteristics, primarily influenced by its non-urban and non-rural layout. This value can be categorised into three types: heritage, asset, and ecological. ③ The third-front construction plants and mines in Hubei Western comprise 27 heritage reuse types, 30 asset reuse types, and 56 ecological reuse types. Finally, the study proposes several measures to facilitate the transformation and revitalisation of the third-front construction stock space. For instance, the Third Front Construction Heritage group intends to initiate the conversion of property rights for the purpose of reducing transaction costs and promoting the transformation of the Third Front Construction Stock Space Association. Additionally, efforts will be made to restore the natural ecosystem of the Third Front construction area, with the aim of achieving rewilding and other dimensions of the proposed pathway. These findings provide valuable theoretical and methodological support for the sustainable development of the third-front construction area and the revitalisation of its stock space.
Cerebrospinal Fluid Total Iron and Fe2+ Strongly Associated with The Incidence of Hydrocephalus in Intracerebral Hemorrhage Patients with Intraventricular Extension
Authors: Wahjoepramono Petra Octavian Perdana , Sasongko Aloysius Bagus , Halim Danny , Wahyudi Kurnia , Adam Achmad , Tsai Yeo Tseng , Wahjoepramono Eka Julianta , July Julius , Achmad Tri Hanggono 
Published: March 2024

Abstract

Background
Hydrocephalus (HCP) is a known complication of spontaneous intracerebral hemorrhage (ICH) extension into the ventricles (IVH) and is associated with poorer patient outcomes. The mechanisms in HCP development are not yet clear. Biomarkers in CSF could predict the risk of shunt-dependent hydrocephalus, to improve clinical outcomes in these patients, and could be more reliable than CT-scan evaluation.
Aim
This study aimed to test the reliability of measuring Fe2+, Fe3+, total iron concentration, and high mobility group box 1 (HMGB1) protein levels as CSF biomarkers to predict the risk of shunt-dependent hydrocephalus in ICH + IVH patients. We compared marker reliability with CT-scan mGraeb score to predict hydrocephalus.
Methods
All adult ICH + IVH patients with hydrocephalus admitted to Siloam Hospitals Lippo Village between March 2021 until December 2023 were included in this cohort study. The patient's clinical and radiological characteristics were retrieved, and CSF samples were obtained during EVD placement. Statistical analyses were performed to reveal potential clinical, radiological, and biomarker values as predictors of shunt-dependent hydrocephalus in ICH + IVH patients.
Results
Thirty-six ICH + IVH + HCP patients, including 16 females (44.4%) and 20 males (55.6%) were included in this study, with mean age of 60.75 years. Seventeen patients (47.2%) were diagnosed with shunt-dependent hydrocephalus. Logistic regression analyses revealed that increased total Fe (p = 0.048) and Fe2+ (0.045) were significantly associated with the incidence of shunt-dependent hydrocephalus. Receiver operating curves (ROC) revealed that the AUCs from total iron (0.716), Fe2+ (0.758), Fe3+ (0.651), and HMGB1 (0.722) are higher than the AUC of mGraeb score (0.528).
Conclusion
Based on the results from logistic regression analyses and constructed ROCs, CSF total iron and Fe2+ are reliable prognosticators of shunt-dependent hydrocephalus in ICH + IVH + HCP patients. These biomarkers are more sensitive and specific in predicting hydrocephalus compared to mGraeb score.
Fluorine-induced d-band center shift of the Nb site boosts anodic formamide electrosynthesis
Authors: Dong Fan , Mou Shiyong , Liu Siyuan , Dai Weidong , Sun Yanjuan 
Published: March 2024

Abstract

Anodic oxidative amidation (EOA) strategies offer a sustainable and potentially promising route for amide synthesis. However, the efficiency and activity of catalysts under oxidative conditions are highly dependent on noble metals. Herein, we present our experimental findings and fundamental understanding that fluorine-doped Nb2O5 nanosheet arrays on carbon fiber (F-Nb2O5/CP) serve as an efficient and robust non-noble catalyst for the electrochemical synthesis of formamide from ammonia and methanol under ambient conditions. In 0.5 M KHCO3 solution, this catalyst achieved a high Faradaic efficiency of 52.0%, with an N selectivity of 79.1% at 1.5 V versus Hg/HgO electrode. The catalyst exhibited remarkable stability, maintaining its performance over 120 h. By integrating in-situ spectroscopy studies with density functional theory calculations, we revealed that fluorine doping induces a shift in the d-band center of the Nb site. This shift alters the adsorption behavior of OH- and *NH2 intermediate on the F-Nb2O5 (100) surface, thereby effectively lowering the C-N coupling energy barrier, and boosting the production of formamide.
Attention deficit hyperactivity disorder and 19 autoimmune diseases: A Mendelian Randomization Study
Authors: Yan Le , Zhang Chuyue , Li Mi 
Published: March 2024

Abstract
Background
Observational studies suggest a connection between autoimmune diseases (AD) and attention deficit hyperactivity disorder (ADHD). Nevertheless, the causality between AD and ADHD is yet to be determined. Therefore, we're employing a twin-sample analysis on Mendelian randomization, with a view to exploring the causality between ADHD and 19 AD.
Method
We evaluated the total statistics of the latest Genome-Wide Association Studies (GWAS) for ADHD2022 (38691 cases, 186843 controls) and 19 common ADs, including Autoimmune thyroiditis, Type 1 diabetes, Celiac disease, Vitamin B12 deficiency anemia, Idiopathic thrombocytopenic purpura, multiple sclerosis, Graves' disease, Sjogren's syndrome, Iridocyclitis, Ulcerative colitis, Crohn's disease, Psoriasis, Alopecia areata, Vitiligo, Rheumatoid arthritis (RA), Myasthenia gravis, Systemic sclerosis, Systemic lupus erythematosus, Ankylosing spondylitis. These summary statistics originated in publicly assessible, relatively large-scale GWAS meta-analyses conducted to date. The causality between ADHD and 19 ADs using inverse variance weighting (IVW), MR-Egger, and weighted median approaches. Cochran's Q statistic was adopted, for the purpose of measuring the heterogeneity of the instrumental variable (IV).
Result
The result indicate that ADHD potentially increases the risk of vitiligo (IVW OR = 2.385, 95%CI, 1.054–5.398, P = 3.69e-02) and suggests an association between ADHD and increased hazard of rheumatoid arthritis (IVW OR = 1.092, 95%CI, 1.009–1.182, P = 2.94e-02). However, no other significant causal relationships were observed in our analyses.
Conclusion
In this research, the causalities between ADHD and 19 ADs were comprehensively assessed. Besides, it was identified genetic evidence suggesting possible causalities between ADHD and vitiligo along with rheumatoid arthritis in European populations.
Plasma biomarkers of amyloid, tau, axonal and neuroinflammation pathologies in dementia with Lewy bodies
Authors: Vrillon Agathe , Bousiges Olivier , Götze Karl , Demuynck Catherine , Muller Candice , Ravier Alix , Schorr Benoit , Philippi Nathalie , Hourregue Claire , Cognat Emmanuel , Dumurgier Julien , Lilamand Matthieu , Cretin Benjamin , Blanc Frederic , Paquet Claire 
Published: March 2024

Abstract
BACKGROUND Increasing evidence supports the use of plasma biomarkers of amyloid, tau, neurodegeneration and neuroinflammation for diagnosis of dementia. However, their performance for positive and differential diagnosis of dementia with Lewy bodies (DLB) in clinical settings is still uncertain.METHODS We conducted a retrospective biomarker study in two tertiary memory centers, Paris Lariboisière and CM2RR Strasbourg, France, enrolling patients with DLB (n = 104), Alzheimer’s disease (AD, n = 76) and neurological controls (NC, n = 27). Measured biomarkers included plasma Aβ ratio, p-tau181, NfL and GFAP using SIMOA and plasma YKL-40 and sTREM2 using ELISA. DLB patients with available CSF analysis (n = 90) were stratified according to their CSF Aβ profile.RESULTS DLB patients displayed modified plasma Aβ ratio, p-tau181 and GFAP levels compared with NC and modified plasma Aβ ratio, p-tau181, GFAP, NfL and sTREM2 levels compared with AD patients. Plasma p-tau181 best differentiated DLB from AD patients (ROC analysis, area under the curve [AUC] = 0.80) and NC (AUC = 0.78) and combining biomarkers did not improve diagnosis performance. Plasma p-tau181 was the best standalone biomarker to differentiate amyloid-positive from amyloid-negative cases (AUC = 0.75) and was associated with cognitive status. Combining plasma Aβ ratio, p-tau181 and NfL increased performance to identify amyloid copathology (AUC = 0.79). Principal component analysis identified different segregation patterns of biomarkers in the DLB and AD groups.CONCLUSIONS Amyloid, tau, neurodegeneration and neuroinflammation plasma biomarkers are modified in DLB, albeit with moderate diagnosis performance. Plasma p-tau181 can contribute to identify Aβ copathology in DLB.
An improved YOLO algorithm with multisensing for pedestrian detection
Authors: Gong Lixiong , Wang Yuanyuan , Huang Xiao , Liang Jiale , Fan Yanmiao 
Published: March 2024

Abstract

Although pedestrian detection techniques are improving, this task is still challenging due to the problems of target occlusion, small targets, and complex pedestrian backgrounds in images of different scenes. As a result, the You Only Look Once (YOLO) algorithm exhibits lower detection accuracy. In this paper, the use of multiple dilated convolutions to sample feature images is proposed avoid the information loss incurred repeated sampling, to improve the feature extraction and target detection performance of the algorithm. In addition, a lightweight shuffle-based efficient channel attention (SECA) mechanism is introduced to conduct grouping in the channel dimension and perform parallel processing for each subfeature map channel. A new branch is introduced to enrich the channel feature information for multiscale feature representation. Finally, a distance intersection over union-based nonmaximum suppression (DIoU-NMS) method is introduced to minimize the occurrence of missed targets due to occlusion by taking the prediction box and ground truth box centroid locations information into account without increasing the computational cost over that of normal NMS. Our method is extensively evaluated on several challenging pedestrian detection datasets, achieving 87.73%, 34.7%, 93.96% and 95.23% mean average precision (mAP) values on PASCAL VOC 2012, MS COCO, Caltech Pedestrian and INRIA Person, which are respectively. The experimental results demonstrate the effectiveness of the method.
Polyunsaturated fatty acids associated with delayed biological aging: NHANES 2005–2010
Authors: Jin Shuo , Zhao Xuan , Hu Lina 
Published: March 2024

Abstract
Background
Research has shown that polyunsaturated fatty acids (PUFAs) have anti-inflammatory, antioxidant, telomere shortening delay and other functions, which can delay biological aging. Phenotypic age (PhenoAge), as a new indicator to assess the level of aging, plays a certain predictive role in the occurrence and development of diseases. The objective of our research was to investigate the association between dietary PUFAs intake and PhenoAge.
Methods
The data for our research was sourced from the National Health and Nutrition Examination Survey (NHANES), covering the years 2005 to 2010. Multivariate linear regression was employed to examine the potential associations. Furthermore, subgroup analyses were used to explore this correlation in different populations. Sensitivity analysis has demonstrated the stability of our conclusion.
Results
Our study included 13326 individuals in total. The mean age was 50.09 years. The median level of PUFAs consumption was 17.07 g/ day. We observed the negative associations between PUFAs intake and PhenoAge after adjusting all covariates (β= -0.03; 95% confidence interval, -0.05 to -0.01). Besides, we categorized PUFAs intake into quartiles and found the existence of a linear relationship after adjusting all covariates (p for trend: 0.002). Subgroup analysis has demonstrated that this negative relationship remains stable across different population groups. The sensitivity analysis also confirms the stability of our conclusion.
Conclusions
In conclusion, our research indicate a negative association between PUFAs intake and PhenoAge. This association demonstrates a linear pattern, which means dietary PUFAs intake was associated with delayed biological aging.
Modelling global freight decarbonisation pathways
Authors: Martinez Luis Miguel G. , Pritchard John P. 
Published: March 2024

Abstract

This paper addresses the urgent need to decarbonise the global freight sector. Using the ITF PASTA modelling framework, it projects freight activity and emissions to 2050 under two policy scenarios of differing climate ambitions. Results reveal that without significant efforts and higher ambitions, global freight transport will not meet climate goals. Regional analyses underscore the importance of international cooperation. The study also discusses challenges in achieving efficiency gains and modal shifts and emphasises the vital role of demand management in successful decarbonisation efforts.
Mild to severe controlled hypotension with nicardipine can maintain intraoperative microcirculatory cerebral blood flow and oxygenation in pigs
Authors: Zuo Dukun , Yang Guiying , Li Yang , Yuan Yaozong , Deng Qiangting , Long Zonghong , Peng Taotao , Li Hong 
Published: March 2024

Abstract

Background
There have been many studies on global cerebral perfusion level, but less attention has been paid to its effect on cerebral microcirculatory perfusion. This study aimed to investigate the effects of nicardipine-induced hypotension on microcirculatory cerebral blood flow and oxygenation in pigs.
Methods
Six healthy female Landrace pigs, aged 4–6 months, weighing 22-25kg were included in this study. Nicardipine was used for controlled hypotension (20%, 30%, 50% lower than baseline mean arterial pressure (MAP), corresponding to mild, moderate and severe hypotension, respectively) under sevoflurane anesthesia. Oxygen to see(O2C), a monitoring instrument, was used to measure regional cerebral blood flow (rCBF) and regional cerebral oxygen saturation (rSO2). rCBF, rSO2, HR, SpO2 were recorded under different MAP.
Results
rCBF was moderately correlated with rSO2(r = 0.671), while MAP was highly correlated with both rCBF and rSO2(r = 0.800 and 0.860, respectively) during hypotension. Both rCBF and rSO2 decreased significantly(P < 0.001) from baseline during mild hypotension, with an average decrease of 6.3% and 2.2%, respectively. During moderate hypotension, rCBF decreased by an average of 11.8% (P < 0.001), while rSO2 fell by an average of 6.5% (P < 0.001). During severe hypotension, the average decrease of rCBF was 19.5%(P < 0.001), while rSO2 decreased by an average of 15.7%(P < 0.001). When MAP recovered after drug withdrawal, both rCBF and rSO2 did not restore, which decreased by 2.7% and 4.3% from baseline, respectively.
Conclusions
The effect of nicardipine on cerebral microcirculation perfusion is limited during mild to severe hypotension. However, for patients with cerebrovascular diseases, there is a high risk of cerebral ischemia and hypoxia during severe hypotension.