bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment Approaches in Pediatric Relapsing Autoimmune Encephalitis
Authors: Yakir Maayan J. , Yang Jennifer H. 
Published: March 2024

Abstract
Purpose of review
Autoimmune encephalitis (AE) is increasingly recognized as a treatable cause of encephalitis in children. While prior observational studies demonstrate improved motor outcomes with early immunotherapy, less is known about long-term management and treatment for relapsing disease. In this review, we present current treatment approaches to pediatric AE, in particular relapse risk and treatment for relapsing AE in children.

Recent findings
A recent meta-analysis of anti-NMDAR encephalitis demonstrated that disease onset in adolescence was associated with an increased odds of relapse whereas treatment with rituximab and IVIG for 6 months or longer were associated with a non-relapsing course. However, no specific pediatric sub-analyses were reported. A single-center study on adult and pediatric AE showed that rituximab use was associated with a reduction in time to relapse and recurring relapses although the data for the pediatric cohort did not achieve statistical significance.

Summary
The use of second-line immunotherapy during the initial attack may reduce the risk for relapsing disease in pediatric AE. Larger studies are needed to investigate relapse risk and treatment in both anti-NMDAR and non-NMDAR encephalitis in children.
Effect of early peri-operative arterial lactate concentration level ratios on post-hepatectomy liver failure
Authors: Wang Dong-Dong , Dong Meng-Meng , Xie Ya-Ming , Xu Fei-Qi , Fu Tian-Wei , Wu Yu-Chen , Zhang Zhe , Lu Yi , Liang Lei , Yao Wei-Feng , Shen Guo-Liang , Liu Jun-Wei , Zhang Cheng-Wu , Xu Qiu-Ran , Xiao Zun-Qiang 
Published: March 2024

Abstract
Background
Post-hepatectomy liver failure (PHLF) is a serious complication after hepatectomy and a major cause of death. The current criteria for PHLF diagnosis (ISGLS consensus) require laboratory data of elevated INR level and hyperbilirubinemia on or after postoperative day 5. This study aims to propose a new indicator for the early clinical prediction of PHLF.

Methods
The peri-operative arterial lactate concentration level ratios were derived from time points within the 3 days before surgery and within POD1, the patients were divided into two groups: high lactate ratio group (≥ 1) and low lactate ratio group (< 1). We compared the differences in morbidity rates between the two groups. Utilized logistic regression analysis to identify the risk factors associated with PHLF development and ROC curves to compare the predictive value of lactate ratio and other liver function indicators for PHLF.

Results
A total of 203 patients were enrolled in the study. Overall morbidity and severe morbidity occurred in 64.5 and 12.8 per cent of patients respectively. 39 patients (19.2%) met the criteria for PHLF, including 15 patients (7.4%) with clinically relevant Post-hepatectomy liver failure (CR-PHLF). With a significantly higher incidence of PHLF observed in the lactate ratio ≥ 1 group compared to the lactate ratio < 1 group (n = 34, 26.8% vs. n = 5, 6.6%, P < 0.001). Multivariable logistic regression analysis revealed that a lactate ratio ≥ 1 was an independent predictor for PHLF (OR: 3.239, 95% CI 1.097–9.565, P = 0.033). Additionally, lactate ratio demonstrated good predictive efficacy for PHLF (AUC = 0.792).

Conclusions
Early assessment of peri-operative arterial lactate concentration level ratios may provide experience in early intervention of complications in patients with hepatocellular carcinoma, which can reduce the likelihood of PHLF occurrence and improve patient prognosis.
FAM83D acts as an oncogene by regulating cell cycle progression via multiple pathways in synovial sarcoma: a potential novel downstream target oncogene of anlotinib
Authors: Liu Zi-mei , Yuan Ying , Jin Lei 
Published: March 2024

Abstract
Objective
Synovial Sarcoma (SS), a highly malignant mesenchymal neoplasm, typically carries a grim prognosis for patients presenting with high-grade or metastatic disease. Although Anlotinib, a new agent for treating soft tissue sarcomas, holds promise, its underlying mechanism remains incompletely understood. This investigation aims to delineate Anlotinib’s anticancer effectiveness and potential mechanistic underpinnings in patients suffering from advanced, refractory SS.

Materials and methods
Employing microarray assay, we examined the potential downstream targets of Anlotinib in SS therapy. A shRNA-based high-content screening was performed to identify candidate genes with the greatest influence on SW982 cell proliferation. The knockdown efficacy of selected genes within SW982 cells was confirmed using RT-qPCR as well as western blot analysis. To assess the effect of putative downstream elimination of genes with synovial sarcoma cells, cell proliferation, and apoptotic assays were carried out. Gene chip microarray as well as bioinformatics techniques were utilized to scrutinize potential signaling networks associated with the candidate downstream gene.

Results
QPCR verified high expression of FAM83D in SW982 cells, shRNA was designed to silence FAM83D by lentivirus transfection, apoptosis assay, and cell cycle arrest showing that FAM83D downregulation augments apoptosis in SW982 cells and arrests cell cycle progression in the S stage. Inhibition of FAM83D expression upregulated STAT1 while downregulated BIRC5, MCM2, and CDK1 genes in vitro.

Conclusions
This experimental study identified FAM83D as a critical regulator that contributes to the proliferation and progression of SS, suggesting that FAM83D-regulated signaling pathway may serve as a prospective target in SS management.
The predictive value of systemic inflammatory markers in 902 patients with tunneled hemodialysis catheter
Authors: Baykara Ulusan Melis , Meltem Emine , Mutlu Ilhan Nahit , Ulusan Kivilcim 
Published: March 2024

Abstract
Aim
This study aimed to assess the predictive role of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, and mean platelet volume, on catheter survival in chronic hemodialysis patients, analyzing both infectious and non-infectious complications.

Methods
A retrospective analysis encompassed 1279 tunneled catheter insertion procedures involving 902 patients between March 2014 and October 2018. Patients were categorized into two main groups: (i) initial placement and (ii) exchange. The exchange group was further stratified into four subgroups: infection, dysfunction, displacement, and transitioning temporary hemodialysis catheters to long-term ones. Hematologic ratios were calculated from baseline hemogram data, including neutrophil, lymphocyte, monocyte, and platelet counts, while mean platelet volume was derived from the same hemogram.

Results
The patients in the exchange group displayed significantly higher lymphocyte and monocyte values (p < 0.001), while lower values were noted for neutrophil–lymphocyte ratio and platelet-lymphocyte ratio (p < 0.001). The transition group displayed higher monocyte values and lower mean platelet volume and lymphocyte-monocyte ratio values (p < 0.05). In the infection-related exchange subgroup, higher neutrophil count, mean platelet volume, neutrophil–lymphocyte ratio, and platelet-lymphocyte ratio values were observed compared to other groups (p < 0.05). Cases related to catheter dysfunction exhibited increased lymphocyte-monocyte ratio but lower neutrophil, monocyte, neutrophil–lymphocyte ratio, and platelet-lymphocyte ratio values (p < 0.05).

Conclusion
This study highlights the interest of specific inflammatory markers, particularly monocytes, neutrophil–lymphocyte ratio, and platelet-lymphocyte ratio, in the management of tunneled catheters, notably in patients undergoing exchanges. However, cut-off values, essential for constructing management algorithms, are currently lacking, and prospective multicenter studies are needed for further elucidation.

Graphical abstract
The sustainability of developmental programs by the U.S. and China in Sub-Saharan Africa: a comparison of effectiveness
Authors: Dagold Mandy , Stimers Mitchel 
Published: March 2024

AbstractThis descriptive comparative qualitative case study examines the sustainability of development programs in Sub-Saharan Africa. We evaluated economic, social, environmental, and institutional development programs from the People’s Republic of China (PRC) and the U.S. to Sub-Saharan Africa for sustainable development to fill the research gap on these technique’s success and effects on Sub-Saharan Africa. Using purposive sampling, we chose eight Sub-Saharan African countries representing distinct geographies and economies. The College of William & Mary’s AID Data-GeoCoded Chinese Official Finance Dataset, China Africa Research Initiative, and USAID’s Foreign Aid Explorer provided data. Results revealed a complex view of Sub-Saharan Africa’s development policy success. Proposition 1, which claims China’s economic tactics exceed those of the U.S., is supported by significant infrastructure investments but presents sustainability problems. Proposition 2, praising the social development initiatives of the U.S., is supported by gains in healthcare and education in other countries. However, context-specific issues persist. Proposition 3 shows that U.S. conservation collaborations have improved environmental preservation. Proposition 4 claims that both countries’ institutional development plans fail. The results highlight local government buy-in issues and the need for adaptation. Some of the ideas find support in recent research; however, country and context differences require unique tactics. Development efforts in Sub-Saharan Africa should focus on long-term sustainability, local objectives, and environmental implications. Effective institutional growth requires adaptation and a strong awareness of local governing dynamics, and policymakers, development practitioners, and scholars may gain insight into sustainability and development projects in Sub-Saharan Africa from this research. A holistic approach that balances economic, social, environmental, and institutional factors is needed to attain sustainable development goals.
For whom and by whom is glaciology?
Authors: Robel Alexander A. , Ultee Lizz , Ranganathan Meghana , Nash Meredith 
Published: March 2024

Abstract
Glacier and ice sheet research is frequently justified on the basis of potential benefits to those communities that are most vulnerable to glacier change. In this glaciology research, funding priorities and communication to the broader public are strongly affected by the experiences and values of glaciology researchers. Using population data and newly available survey data from research organizations including glaciologists, we show that there is a substantial misalignment between the demographics of those who stand to benefit from glaciological research and those who produce glaciological knowledge. We discuss the potential negative consequences of this misalignment, which causes scientific research to be less effective, valuable and usable for communities. We conclude by outlining twenty evidence-based strategies that individuals and organizations can adopt to improve the recruitment and retention of a more representative group of scientists in glaciological research and encourage co-production with communities.
Making Reasonable Adjustments for Students With Disability in Australian Mainstream Classrooms: A Scoping Review
Authors: Page Angela , Barr Megan , Rendoth Tess , Roche Laura , Foggett Judith Louise , Leonard Carl , Duncan Jill 
Published: March 2024

AbstractReasonable adjustments are measures and actions that have been adopted in Australia to assist students with disability to participate in their learning on the same basis as their peers in a way that is free of inequality and exclusion. However, little research explores the enablers and barriers associated with implementing reasonable adjustments to support student learning. Therefore, research-based guidance regarding how best to direct the successful implementation of reasonable adjustments is required. This scoping review of 25 studies found a limited body of research that suggested reasonable adjustments are an effective means to address learner diversity; however, several barriers exist in teacher and school attitudes towards making adjustments, as well as how policy of reasonable adjustments can be systematically applied. A model of best practice summarises a strategy to address these significant themes.
Cliff recession geodynamics variability and constraints within poorly consolidated landslide-prone coasts in the southern Baltic Sea, Poland
Authors: Frydel Jerzy Jan 
Published: March 2024

AbstractThis study identifies the reasons for geodynamics variability of the coastal system within two cliff-shore sections of the southern Baltic Sea (SBS). The comparative analysis included distinct moraines and their foregrounds near the open sea (S1) and within the Gulf of Gdańsk (S2). Short-term trends indicate a direct link between landslide occurrence and increased cliff retreat. Long-term (total) values were obtained by developing the 4F MODEL for large-scale applications, based on the analysis of remote sensing and hydroacoustic data (to determine the extent of shore platforms), the modelling of higher-order polynomial functions describing their extent, followed by the integral calculus of the indicated functions within the open-source Desmos environment. The retreat dynamics for individual landslides (S1) was an order of magnitude higher (m/yr) than the average for the whole cliff section (0.17 ± 0.008 m/yr), which correlates well with medium- and long-term development tendencies and recession dynamics, revealed by the numerical modelling method, since approximately 8 ka b2k, years before 2000 CE (at S1 = 0.17 ± 0.020 m/yr, at S2 = 0.11 ± 0.005 m/yr). While the approach described in this paper can reveal, project, and simulate the dynamics of past and future trends within other cliffed coasts shaped in tideless conditions, it also proves stable moraine erosional responses to sea-level rise since the Mid-Holocene.
Configuring Cultural Emerging Industries: A Comparison of the French and Italian Fashion Industries
Authors: Merlo Elisabetta , Pinchera Valeria 
Published: March 2024

AbstractThis paper builds on a body of multi-disciplinary literature to analyze and compare the emergence of the prêt-à-porter industry in France and the ready-to-wear industry in Italy from their founding to their growth stages in the mid-twentieth century. The comparison demonstrates the significant impact that the French Chambre Syndicale de la Couture, des Confectionneurs et des Tailleurs pour Dame, and the National Chamber of Italian Fashion had on the trajectories of the fashion industry for each country. The article focuses on foundational entrepreneurs within the industry such as Giovanni Battista Giorgini, Jean Patou, Coco Chanel, Christian Dior, and others. It analyzes how these chambers supported the emergence of differentiated firms within the fashion industry, and how the industry responded to the business conditions in the international economy of the post-World War II period through the global recession of the 1970s.
Borrowing without Banks: Deposit-Taking by Early Twentieth-Century Chinese Firms (1920s–1930s)
Authors: Ng Michael 
Published: March 2024

AbstractThis article examines how and why renowned Republican-era Chinese firms raised debt capital to finance their businesses by accepting savings deposits from ordinary people instead of borrowing from financial institutions. The article argues that in the absence of a powerful unitary state and centralized financial institutions, Chinese firms innovated sophisticated, decentralized financial instruments capable of amassing large quantities of capital from a broad host of depositors without the involvement of financial intermediaries. Savings deposits not only provided these firms with a cheaper and more flexible source of debt capital than that on offer from banks but also they fueled the Chinese economy by creating a sizable credit supply, a phenomenon that Chinese business and financial history scholarship focusing on the role of indigenous and modern banks has hitherto largely neglected.
Mestizo Urbanism: Enduring Racial Intersections in Latin American Cities
Authors: Torino Giulia 
Published: March 2024

AbstractAcross Latin America, there continues to be strong resistance to the claim that racism plays a role in the production of urban space. Deemed antipatriotic, this issue remains widely unaddressed in urban planning and geography. Based on qualitative research in Bogotá and secondary literature on other Latin American cities, this article explores the afterlife of mestizaje (racial mixture) as a racial–colonial project from the viewpoint of its materialisation in the city and society–space relations. In particular, it illustrates how racism in the city is transfigured as ‘always something else’ (e.g., culture, class, regionalism, displacement) through a variety of normative, discursive and operational devices. Thus, the article confronts the need to divest from the racial hegemony of mestizaje in urban planning and geography, suggesting that it is hindering the path towards more equitable urban futures.
The Spatiotemporal Clustering of Short‐Duration Rainstorms in Shanghai City Using a Sub‐Hourly Gauge Network
Authors: Lei Nuo , Gao Lisha , Liu Shuguang , Zhou Zhengzheng 
Published: March 2024

AbstractImpacted by both the large‐scale climate change and the local hydrometeorological atmosphere, the spatiotemporal structure and properties of short‐duration extreme rainfall events in urban areas remain a complex issue. This study explores the spatiotemporal pattern variability of short‐duration rainstorm events using an exceptional sub‐hourly gauge network in Shanghai, China. A catalog of 207 “independent” rainstorms is extracted. The hierarchical clustering method is used to examine the spatial and temporal features including rainfall duration, intensity, and coverage for each district with different degrees of urbanization in the 2014–2018 period. The results point to a pronounced spatial heterogeneity with heavier rainfall magnitude in the north. In the urban core area, intensive short‐duration rainstorms hit more frequently than in other districts. Rainstorms can be divided into three types from the spatiotemporal process: Type delayed‐slow, Type advanced‐fast, and Type advanced‐slow. The delayed‐peak with a higher slope occurs more in the west and the advanced‐peak more along the coastal line. The other type of advanced‐peak storm with a reverse trend of intensity and coverage concentrates in June–August of the year and the 16:00–20:00 of the day. While 65.6% of the delayed‐peak storms only occur in one district, more than half of the advanced‐peak appear without other types at the same time. These findings show the importance of observation‐based analysis in understanding the spatiotemporal pattern of short‐duration storms and provide a reference for storm design of sub‐regions in urban areas.
Spatial Heterogeneity of Pore Structure in the Crustal Section of the Samail Ophiolite: Implications for High VP/VS Anomalies in Subducting Oceanic Crust
Authors: Akamatsu Y. , Kuwatani T. , Katayama I. 
Published: March 2024

AbstractSeismic surveys along subduction zones have identified anomalously high ratio of P‐ to S‐wave velocity (VP/VS) in the subducting oceanic crust that are possibly due to the presence of pore water. Such interpretations postulate that the pore structure is homogeneous at the scale of the seismic wavelength. Here we present the first statistical evidence of a heterogeneous pore structure in oceanic crust at scales larger than laboratory samples. The spatial correlation of measured bulk density profiles of the crustal section of the Samail ophiolite suggests that the pore structure is heterogeneous at scales smaller than ∼1 m. Wave‐induced fluid flow cannot follow the loading during the seismic wave propagation at this estimated heterogeneity, which implies that fluid‐filled microscopic pores and cracks have a limited impact on the observed high VP/VS anomalies in the subducting oceanic crust. Large‐scale cracks may therefore play an important role in shaping these anomalies.
Valuing Combinations of Flexible Planning, Design, and Operations in Water Supply Infrastructure
Authors: Willebrand Keani , Zaniolo Marta , Skerker Jennifer , Fletcher Sarah 
Published: March 2024

AbstractUncertainty arising from climate change poses a central challenge to the long‐term performance of many engineered water systems. Water supply infrastructure projects can leverage different types of flexibility, in planning, design, or operations, to adapt infrastructure systems in response to climate change over time. Both flexible planning and design enable future capacity expansion if‐and‐when needed, with flexible design proactively incorporating physical design changes that enable retrofits. All three forms of flexibility have not previously been analyzed together to explicitly assess their relative value in mitigating cost and water supply reliability risk. In this paper, we propose a new framework to evaluate combinations of flexible planning, design, and operations. We develop a nested stochastic dynamic optimization approach that jointly optimizes dam development and operating policies under dynamic climate uncertainty. We demonstrate this approach on a reservoir project near Mombasa, Kenya. Our results find that flexible operations have the greatest potential to reduce costs. Flexible design and flexible planning can amplify the value of flexible operations under higher discounting scenarios and when initial infrastructure capacities are undersized. This approach provides insight on the climate change and techno‐economic conditions under which flexible planning, design, and operations can be best leveraged individually or in combination to reduce climate change uncertainty risks in water supply infrastructure projects.
Impaired binding affinity of YTHDC1 with METTL3/METTL14 results in R-loop accumulation in myelodysplastic neoplasms with DDX41 mutation
Authors: Hwang Won Chan , Park Kibeom , Park Silvia , Cheon Na Young , Lee Ja Yil , Hwang Taejoo , Lee Semin , Lee Jong-Mi , Ju Min Kyung , Lee Joo Rak , Kwon Yong-Rim , Jo Woo-Lam , Kim Myungshin , Kim Yoo-Jin , Kim Hongtae 
Published: March 2024

AbstractDEAD box helicase 41 (DDX41) mutations are the most prevalent predisposition to familial myelodysplastic syndrome (MDS). However, the precise roles of these variants in the pathogenesis of MDS have yet to be elucidated. Here, we discovered a novel mechanism by which DDX41 contributes to R-loop-induced DNA damage responses (DDR) in cooperation with the m6A-METTL complex (MAC) and YTHDC1 using DDX41 knockout (KO) and DDX41 knock-in (KI, R525H, Y259C) cell lines as well as primary samples from MDS patients. Compared to wild type (WT), DDX41 KO and KI led to increased levels of m6A RNA methylated R-loop. Interestingly, we found that DDX41 regulates m6A/R-loop levels by interacting with MAC components. Further, DDX41 promoted the recruitment of YTHDC1 to R-loops by promoting the binding between METTL3 and YTHDC1, which was dysregulated in DDX41-deficient cells, contributing to genomic instability. Collectively, we demonstrated that DDX41 plays a key role in the physiological control of R-loops in cooperation with MAC and YTHDC1. These findings provide novel insights into how defects in DDX41 influence MDS pathogenesis and suggest potential therapeutic targets for the treatment of MDS.