bluuebunny/crossref_metadata_2025_split huggingface dataset:
Severity Predictors for Multisystemic Inflammatory in Children after SARS-CoV-2 Infection: A Prospective Observational Study from Vietnam
Authors: Tran Dien. M. , Pham Dem. V. , Cao Tung. V. , Hoang Canh. N. , Nguyen Ha. T. , Nguyen Giang. D. , Le Cuong. N. , Thieu Quan. Q. , Ta Tuan. A. , Dau Hung. V. , Le Chi. Q. , Le Quang. H. , Luong Nghiem. T. , Tran Mai. T. , Nguyen Phu. H. , Nguyen Nhung. T. , Phan Phuc. H. 
Published: February 2024

Abstract
Multisystemic inflammatory in children (MIS-C) might manifest in a broad spectrum of clinical scenarios, ranging from mild features to multi-organ dysfunction and mortality. However, this novel entity has a heterogenicity of data regarding prognostic factors associated with severe outcomes. The present study aimed to identify independent predictors for severity by using multivariate regression models. A total of 391 patients (255 boys and 136 girls) were admitted to Vietnam National Children’s Hospital from January 2022 to June 2023. The median age was 85 (range: 2–188) months, and only 12 (3.1%) patients had comorbidities. 161 (31.5%) patients required PICU admission, and the median PICU LOS was 4 (2–7) days. We observed independent factors related to PICU admission, including CRP \(\ge\)50 (mg/L) (OR = 2.52, 95%CI;1.39–4.56, p = 0.002), albumin \(\le\)30 (g/L) (OR = 3.18, 95%CI;1.63–6.02, p = 0.001), absolute lymphocyte count \(\le\)2 (×109/L) (OR = 2.18, 95%CI;1.29–3.71, p = 0.004), ferritin ≥300 (ng/mL) (OR = 2.35, 95%CI;1.38–4.01), p = 0.002), and LVEF < 60 (%) (OR = 2.48, 95%CI;1.28–4.78, p = 0.007). Shock developed in 140 (35.8%) patients, especially for those decreased absolute lymphocyte \(\le\)2 (×109/L) (OR = 2.48, 95%CI;1.10–5.61, p = 0.029), albumin \(\le\)30 (g/L) (OR = 2.53, 95%CI;1.22–5.24, p = 0.013), or LVEF <60 (%) (OR = 2.24, 95%CI;1.12–4.51, p = 0.022). In conclusion, our study emphasized that absolute lymphocyte count, serum albumin, CRP, and LVEF were independent predictors for MIS-C severity, which required further well-designed investigations on validation. As MIS-C is a new entity and severe courses may progress aggressively, the identification of high-risk patients optimizes clinicians' follow-up and management to improve disease outcomes.
Exploring the mechanism of Radix pseudostellariae in the treatment of chronic gastritis based on network pharmacology and molecular docking techniques
Authors: Li Yuan , Chen Shunhuan , Zhai Dongyan , Tan Yong , Tang Xiaoke , Li Lailai 
Published: February 2024

Abstract

Radix pseudostellariae (RP) has been used for the treatment of various diseases, including gastric disorders such as Chronic gastritis (CG), However, the multi-targeting mechanism of RP on CG still needs to be clarified. Drug targets were established through TCMSP, PubChem and Swiss Target Prediction online database. GeneCards database was used to search for chronic gastritis related targets. Cytoscape was utilized to construct the "drug-active ingredient-target" network relationship diagram. Venny plots of drug targets and disease targets were obtained from online software to get the intersecting genes, and the coincidence targets were imported into STRING database to construct a PPI network. The intersecting targets were subjected to pathway enrichment analysis KEGG and GO functional enrichment analysis with the help of the DAVID database. Molecular docking was performed by Autodocktools software and then visualized by PYMOL. 8 active ingredients and 117 action targets were obtained for Radix Pseudostellariae, 758 action targets for chronic gastritis disease, 31 intersecting targets for Radix Pseudostellariae in chronic gastritis were obtained. PPI network analysis showed that the core targets of the drug affecting chronic gastritis were TNF, MMP9, AKT1, etc. The molecular docking validation results showed good binding of core components and core targets.
Comparison of Comprehensive Genomic Profiling Testing “Ion Torrent Genexus Sequencer” with FoundationOne
Authors: Fujiyoshi Kenji , Sugihara Rie , Miyamoto Naoki , Watanabe Yoriko , Sudo Tomoya , Numata Sanae , Akiba Jun , Abe Hideyuki , Ichinose Yuka , Inoue Kenji , Ozono Shuichi , Okabe Yoshinobu , Ono Takeharu , Orioka Kentaro , Kashihara Masaki , Kajiwara Ryousuke , Kawano Hiroyuki , Kawahara Akihiko , Takase Ryuta , Toh Uhi , Hashimoto Kazuaki , Hisaka Toru , Hirai Shingo , Mitsuoka Masahiro , Miyazaki Daiki , Yoshitomi Fumi , Yamamoto Ken , Umeno Hirohito , Nomura Masahisa , Naito Yoshiki 
Published: February 2024

Abstract
Background
Molecular diagnostic tests are becoming increasingly routine, and the use of tissue- and blood-based next-generation sequencing (NGS) is integral to the delivery of personalized medicine for targeted cancer therapy. This study aimed to evaluate the variant concordance for somatic variants using two clinical NGS systems for conducting both tissue- and blood-based analyses: Genexus-OCA v3 (OCA) vs. FoundationOne CDx (F1) for tissues and Genexus OPA (OPA) vs. FoundationOne CDx Liquid (F1L) for blood.
Methods
The concordance of genomic alterations between the two NGS analyses was compared in six patients with breast, head, and neck cancers using tissue and circulating tumor DNA biopsies.
Results
A total of 130 genes were common between F1 and OCA, and 41 between F1L and OPA. When comparing FoundationOne to Genexus for common genes, the sensitivity and specificity of OCA and OPA were 55% and 99%, respectively. Nine single-nucleotide variants (SNVs), one copy number alteration (CNA), and one fusion were detected by both Genexus and FoundationOne. However, one SNV (MAP2K1 F53V), two CNAs (AKT3 and MYC), and one fusion (ESR-CCDC170) were detected only in Genexus, whereas two SNVs (TP53 Q331* and KRAS G12V) were detected only in FoundationOne.
Conclusion
The two cancer genome panels were equivalent but not perfect in terms of the detection of variants using tissue and blood, indicating that different assays and analytical methods may have influenced the results. When performing comprehensive genomic profilings (CGPs), it is important to consider the characteristics of each NGS-based CGP test and the genetic variants associated with each disease.
Secondary bladder cancers after radiotherapy and radical prostatectomy for the treatment of prostate cancer
Authors: Terao Hideyuki , Nagasaka Hirotaka , Yamamoto Shotaro , Suzuki Atsuto , Usui Kimitsugu , Nakaigawa Noboru , Kishida Takeshi , Watanabe Kaname , Nakamura Sho , Narimatsu Hiroto 
Published: February 2024

Abstract
Purpose:
Long-term survival can be achieved in patients with localized prostate cancer (PCa) treated with radical prostatectomy (RP) or radiotherapy (RT). However, secondary bladder cancer (BCa) development remains poorly understood. We investigated the effect of primary PCa treatment on the subsequent risk of developing a second primary BCa.
Methods:
We compared men who underwent RT for PCa with those who underwent RP. In total, 60195 patients with PCa were registered in the Kanagawa Cancer Registry between 1959 and 2017. Our primary objective was to investigate the effects of RT and RP on the incidence of secondary BCa. Cumulative incidence plots and multivariable Cox regression models were tested for second BCa rate differences according to the treatment type (RT vs. RP). Cumulative incidence was calculated as the competing risk of mortality. Hazard ratios were calculated using the fine-gray proportional hazards regression model.
Results:
Of the 60195 individuals included in the study, 8090 were treated with RT, and 12387 were treated with RP. Median follow-up was 69.3 months (1.0-486.4 months). The cumulative incidence of secondary BCa did not differ between patients treated with RT (3.78%) and those treated with RP (1.39%, p < 0.05). There was an increased risk of BCa (hazard ratio 1.70, 95% confidence interval 1.24 to 2.31) after RT compared with the risk in individuals after RP.
Conclusions:
Patients treated with RT are at an increased risk of developing a second primary BCa compared with those treated with RP.
Criterion Validity of a Single-Item Measure of Fear Avoidance Behavior Following Mild Traumatic Brain Injury
Authors: Amin Shahrazad , Mikolic Ana , Silverberg Noah D. 
Published: February 2024

Abstract

Maladaptive coping such as fear avoidance behavior can prolong recovery from mild traumatic brain injury (mTBI). Routine assessment of fear avoidance may improve management of mTBI. This study aimed to validate a single-item measure of fear avoidance to make its assessment more pragmatic. The present study is a secondary analysis of a clinical trial that involved adults with persistent post-concussion symptoms (N = 90, 63% female). Participants completed the single-item fear avoidance rating, a validated legacy measure of fear avoidance (Fear Avoidance Behavior after Traumatic Brain Injury; FAB-TBI), and measures of anxiety (General Anxiety Disorder-7), depression (Patient Health Questionnaire-9), post-concussion symptoms (Rivermead Postconcussion Symptoms Questionnaire), and disability (World Health Organization Disability Assessment Schedule 12.0). Questionnaires were completed twice, at baseline (mean 18.1 weeks post injury) and again 12–16 weeks later following study-delivered rehabilitation in addition to usual care. We analyzed the associations (Spearman’s correlations) and agreement (Bland-Altman plots) between the single-item and FAB-TBI at baseline, posttreatment, and the change in scores between baseline and posttreatment. In addition, we examined correlations between the single-item avoidance scale and related constructs, including anxiety, depression, post-concussion symptoms, and disability. The single-item fear avoidance measure correlated strongly with the FAB-TBI both at baseline and following treatment (ρ = .63 − .67, p < .001). The correlation between the change in these scores from baseline to posttreatment was moderate (ρ = .45, p < .001). Before and after treatment, the single-item fear avoidance measure correlated moderately with anxiety (ρ = .34), depression (ρ = .43), post-concussion symptoms (ρ = .50), and disability (ρ = .43). The FAB-TBI was more strongly correlated with these measures (ρ = .53 − .73). In summary, the present study supports the criterion validity of the single-item fear avoidance measure. This measure may be a useful screening and monitoring tool for patients with mTBI but is not a substitute for the FAB-TBI questionnaire.
Therapeutic hypothermia and beta-blocker administration in optimizing oxygenation in a porcine model of ARDS under VV ECMO
Authors: Vincendeau Maud , Klein Thomas , Groubatch Frederique , Tran N’Guyen , Kimmoun Antoine , Levy Bruno 
Published: February 2024

Abstract
Background
Acute Respiratory Distress Syndrome (ARDS) remains a significant challenge in critical care, with high mortality rates despite advancements in treatment. VenoVenous ExtraCorporeal Membrane Oxygenation (VV-ECMO) is utilized as salvage therapy in refractory cases. However, insufficient arterial saturation can occur in some patients on VV-ECMO, prompting the exploration of strategies to enhance oxygenation.
Methods
Using a porcine model of severe ARDS treated with VV-ECMO, this study investigated the efficacy of moderate hypothermia and landiolol in improving oxygenation within the first six hours after ECMO initiation. Primary endpoints included ECMO output to cardiac output ratio, arterial oxygen saturation (SaO2), and safety criteria encompassing heart rate, rhythm disorders, hemodynamics, tissue perfusion, and amine supply.
Results
Twenty-four male pigs underwent the study protocol, with animals randomized into hypothermia (n = 9), Landiolol (n = 7), and control (n = 6) groups. At baseline, all groups demonstrated similar hemodynamic and respiratory parameters. Both hypothermia and Landiolol groups exhibited a significant increase in ECMO to native cardiac output ratio at H3 compared to baseline, resulting in improved SaO2. Notably, static compliance remained comparable across groups, indicating consistent lung function. Safety criteria analysis revealed no significant rhythm disorders and lactate levels remained stable throughout the experiment.
Conclusions
In a porcine model of severe ARDS treated with VV-ECMO, both moderate hypothermia and landiolol demonstrated enhanced oxygenation, attributed to increased ECMO blood flow/cardiac output ratio. These interventions showed no adverse effects, suggesting their potential utility in improving oxygenation in refractory ARDS cases.
Risk Assessment of Radioactive Elements in Atmospheric Dust Around Cement Stores in three States,Nigeria
Authors: Faraday Ediagbonya Thompson , Emmanuel Emmanuel Oghenvovovwero Esi , Francis Sabastine Dekas , Elumah Oziegbe Friday , Timilehin Adelani Gabriel 
Published: February 2024

Abstract
This research investigates the numerous facts of radioactive elements, including their origins, how they impact various ecosystems, how they affect living beings as well as inanimate objects, how they can be quantified, and how they can be cleaned up. Samples were collected from Wuye Abuja, Guzape Abuja, Ore Ondo State, Ilado Ondo State, and Irele Ondo State, which are all locations in Nigeria. Each of these locations has a unique climate as well as other environmental characteristics. Ionizing radiation-emitting substances can be found in nature as well as be produced artificially. They have raised concerns because of their potential to harm nearby materials and living organisms. Obtaining a complete picture of how radioactive elements behave around the planet is the aim of this study. To understand how radioactive materials enter the environment, research examines both natural (such as uranium and thorium) and man-made (such as nuclear fallout) sources. For Samples A, B, C, D, and E, the mean concentrations of radium (Ra-226) are 185.20, 162.53, 142.28, 97.27, and 100.70, respectively. For Samples A, B, C, D, and E, the mean concentrations of uranium (U-238) are, respectively, 83.48, 84.60, 70.17, 47.57, and 48.07. Thorium (Th-232) average concentrations for Samples A, B, C, D, and E are 33.07, 26.86, 31.53, 26.40, and 27.60, respectively. While the mean potassium (K-40) concentrations for Samples A, B, C, D, and E are, respectively, 224.47, 115.70, 127.07, 62.30, and 78.33.Except for Uranium (U-238) with 84.60 in sample B, the results showed a significant difference in sample A. The highest values of Radium (Ra-226), Thorium (Th-232), and Potassium (K-40) were 185.20, 33.07, and 224.47, respectively.
The Current Landscape of Ohio Otolaryngologists and Associated Conditions: A State- Level Analysis
Authors: Borgemenke Samuel , Beverly Elizabeth A. 
Published: February 2024

Abstract
Background
As demographics continue to shift in the United States, the access gap to doctors in specialized fields remains of utmost importance. This study quantifies the prevalence of otolaryngologists and otolaryngology subspecialists in Ohio, emphasizing related head and neck conditions.
Methods
This cross-sectional study utilized data from the Centers for Medicare & Medicaid Services (CMS) and the CDC's Wide-Ranging Online Data for Epidemiologic Research (CDC WONDER) mortality file. Health outcomes for all 88 counties in Ohio, classification of Appalachian counties versus non-Appalachian counties, and data on otolaryngologists were assessed. The distribution of otolaryngologists was compared using t-tests and proportion tests. A t-test was conducted to analyze disparities in the prevalence of hearing impairment and oral malignancies. The relationship between otolaryngologists and various social determinants of health was explored via Pearson correlation tests.
Results
The results in this study showed that Appalachian and southeastern counties have fewer otolaryngologists (P < 0.001) and subspecialists (P < 0.001). A significant negative relationship was observed between otolaryngologists and rurality (R=-0.2, P = 0.02) and long commutes (R=-0.2, P = 0.01).
Conclusion
The study demonstrated lower rates of otolaryngologists and subspecialists in southeast and Appalachian areas. This may result in longer travel distances for patients or reliance on less specialized healthcare providers. Significant correlations between the prevalence of otolaryngologists and various social determinants of health were found, emphasizing the difficulties residents in southeastern and Appalachian Ohio face when accessing healthcare. The study calls for a multifaceted approach to ensure equitable healthcare access, between healthcare providers, policymakers, and cultural competence.
Achieving Carbon Neutrality in the Brics Countries: the Roles of Innovation, Renewable Energy, Economic Growth and Carbon Taxes
Authors: Gyedu Samuel , Tang Heng 
Published: February 2024

Abstract
In order to reach the carbon neutrality (CAN) target, this current study examined the roles of research and development (R&D), patent (PAT), economic growth (ECG), renewable energy consumption (REC), renewable internal freshwater (RIF) and carbon taxes (CAT) in achieving CAN from BRICS perspective. We employed panel data of BRICS countries from 2000 to 2020 with second-generational econometric estimators (AMG and CCEMG). We discovered that R&D, RIF and CAT promote CAN by mitigating carbon emissions (CO2) and methane emissions (CH4). Our findings indicated REC contributes massively in achieving CAN. ECG was found to initially delays CAN objective. We detected Environmental Kuznets Curve (EKC) in BRICS. URB and IND also had controlling influence by prolonging CAN agenda. The authors found a feedback mechanism from ECG, REC, RIF, CAT to CO2, and from R&D, REC, RIF, CAT and URB to CH4 in BRICS, indicating that R&D, ECG, REC, RIF, and CAT granger cause to CAN and vice versa. Finally, based on the country-wise details analysis of the variables, China recorded the highest CO2, CH4, ECG and PAT, India had the highest R&D, Brazil the highest REC, and Russia the highest RIF and CAT.
The role of VR with haptic feedback in enhancing physical examination skills of health care students: a systematic review
Authors: Sampath Kesava Kovanur , Corcoran Daniel , McLeod Gopi Anne , Muddle Lee , Tripodi Nicholas , Feehan Jack , Chidambaranathan Kumaresan , Andersen Patrea , Treffel Loic , Ceretelli Fransceco , Arumugam Ashokan 
Published: February 2024

Abstract

Background
Physical examination involves clinical skills where therapists or trainees use their hands to assess tissues or joints for the presence or absences of abnormalities. The traditional “See one, do one, teach one” approach to teach these techniques has been shown to be inadequate. Therefore, digital applications such as virtual reality (VR) have been recommended to assist in teaching physical examination skills of health care students. The aims of this systematic review are to 1) Summarise the level of evidence for the current usage of VR with haptic feedback in health education for improving physical assessment skills among students; and (2) To synthesise the literature on facilitators and barriers for implementing VR with haptic feedback as a health education tool in improving physical assessment skills of students.
Methods
The following electronic databases were searched: PubMed, AMED, EMBASE, CINAHL, Cochrane Library, Physiotherapy Evidence Database (PEDro), and SCOPUS. Two independent reviewers reviewed the articles retrieved from the databases to assess for eligibility. Studies of any methodology (quantitative, qualitative and mixed methods) that investigated the use of VR were included in the review. Primary outcomes included any quantifiable outcome and/or qualitative outcome/feedback. Narrative synthesis was used to synthesise data from the included studies.
Results
A total of 9 studies were included in the final review. Overall, our review found ‘very low’ evidence that VR with haptic feedback may improve palpation of stiffness, palpation speed and palpation accuracy. A ‘conditional recommendation of the intervention’ depending on the context, access and resources required to set-up the required technology.
Discussion
Our review indicates that VR with haptic feedback may enhance palpatory skills of health care students. However, the applicability of evidence may be confined to palpatory skills of health students rather than physical examination skills of health students. Hence, more research is required to identify whether VR with haptic feedback does improve physical examination skill of students.
Anti-PD-1 therapy-induced aGvHD is associated with abnormal IL-1β and NKG2A level in AML patients with relapse post-UCBT
Authors: Zhu Xiaoyu , Wang Dongyao , Qiang Ping , Dai Xiaokang , Yan Peidong , Xu Jin , Wang Yuting , Xie Jiajia , Sun Guangyu , Pan Bo , Yang Jianbo , Zhang Chi , Xu Li 
Published: February 2024

Abstract

Relapse is a major cause of death after allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia (AML). Treatment options for patients who relapse are very limited. Programmed death (PD)-1 blockade has shown therapeutic activity in selected hematologic malignancies, but would trigger severe graft-versus-host disease (GvHD), which is a major obstacle to its success. Herein, we reported the results of sequential PD-1 blockade therapy in patients with relapsed AML after umbilical cord blood transplantation (UCBT). We undertook positron emission tomography–computed tomography to assess the efficacy of sequential PD-1 blockade in patients with AML who relapsed after UCBT. Adequate biopsy analyses revealed an increased number of pro-inflammatory macrophages and increased interleukin-1β (IL-1β) expression in the colon and skin of a patient with severe acute (a)GvHD post-anti-PD-1 therapy. Importantly, we demonstrated low expression of NKG2A in the skin and blood of a patient with aGvHD after anti-PD-1 therapy. Our findings imply that dynamic detection of NKG2A expression in blood or IL-1β expression in tissue could indicate GvHD, and contribute to guiding treatment decisions for sequential PD-1 blockade therapy.
Relative age effects and implications for sport performance in elite Chinese junior male basketball players
Authors: Jiaxin Deng , Liu Yongfeng , Tong Wang , Weicheng Li 
Published: February 2024

Abstract
Background The relative age effect (RAE) has been a hot topic in the field of sport research, and although the phenomenon has been found in most sports in China, there is currently no literature on the RAE phenomenon in Chinese basketball, which has implications for explaining some of the phenomena in that sport. A large body of research suggests that RAE contributes significantly to the phenomena of brain drain and inequality in sport participation. The purpose of this study was to analyses whether RAE exists in Chinese youth men's basketball and whether RAE has an impact on the performance of athletes and teams, thus supporting the subsequent proposal of measures to balance the age effect.Methods This study analyzed the date of birth and performance rankings of all male athletes (n = 3926) who participated in the Chinese Youth Basketball Championships (U14, U15, and U17) from 2021–2023. The study divided the month of birth into quarters and semesters. Differences between actual observed and theoretical birth date distributions were statistically analyzed using the chi-square test, and subsequent calculations were made using the dominance ratio test.Results It was found that RAE was present in all three groups of Chinese youth male basketball players (p < 001). The percentages of athletes born in the first half of the year were 61.2% (U14), 59.9% (U15), and 59.0% (U17), and the percentages of athletes born in the first quarter were 38.6% (U14), 35.8% (U15), and 34.8% (U17).Conclusions As a result of RAE, U15 athletes born closer to the beginning of the year are likely to achieve better results, whereas athletes born closer to the end of the year are less likely to achieve athletic excellence.