bluuebunny/crossref_metadata_2025_split huggingface dataset:
Involvement of neurotrophin‐4/5 in regeneration of the periodontal Ruffini endings at the early stage
Authors: Jabbar Shahiqul , Harada Fumiko , Aita Megumi , Ohishi Megumi , Saito Isao , Kawano Yoshiro , Suzuki Akiko , Nozawa‐Inoue Kayoko , Maeda Takeyasu 
Published: January 2007

AbstractLittle is known about the role of neurotrophin‐4/5 (NT‐4/5) in the regeneration of mechanoreceptors. Therefore, the present study examined the regeneration process of Ruffini endings in the periodontal ligament in nt‐4/5‐deficient and wildtype mice following transection of the inferior alveolar nerve by immunohistochemistry for protein gene product 9.5 (PGP 9.5), a general neuronal marker, and by computer‐assisted quantitative image analysis. Furthermore, rescue experiments by a continuous administration of recombinant NT‐4/5 were performed and analyzed quantitatively. At postoperative day 3 (PO 3d), almost all PGP 9.5‐positive neural elements had disappeared; they began to appear in both types of animals at PO 7d. At PO 10d, almost all nerve fibers showed a beaded appearance, with fewer ramifications in both types of mice. Although the regeneration proceeded in the wildtype, a major population of the periodontal Ruffini endings continued to display smooth outlines at PO 28d in the nt‐4/5 homozygous mice. The reduction ratio of neural density reached a maximum at PO 3d, decreased at PO 10d, and later showed a plateau. In a rescue experiment, an administration of NT‐4/5 showed an acceleration of nerve regeneration in the homozygous mice. These findings indicate that the nt‐4/5‐depletion causes a delay in the regeneration of the periodontal Ruffini endings, but the delay is shortened by an exogenous administration of NT‐4/5. Combined with our previous findings of bdnf‐deficient mice (Harada et al. [2003] Arch Histol Cytol 66:183–194), these morphological and numerical data suggest that multiple neurotrophins such as NT‐4/5 and brain‐derived neurotrophic factor (BDNF) play roles in their regeneration in a stage‐specific manner. J. Comp. Neurol. 501:400–412, 2007. © 2007 Wiley‐Liss, Inc.
Regionalized expression of ADAM13 during chicken embryonic development
Authors: Lin Juntang , Redies Christoph , Luo Jiankai 
Published: January 2007

AbstractADAMs are a family of membrane proteins possessing a disintegrin domain and a metalloprotease domain, which have functions in cell–cell adhesion, cell–matrix adhesion, and protein shedding, respectively. ADAMs are involved in morphogenesis and tissue formation during embryonic development. In the present study, chicken ADAM13 was cloned and identified, and its expression was investigated by semiquantitative reverse transcriptase‐polymerase chain reaction and in situ hybridization during chicken embryonic development. Our results show that ADAM13 expression is temporally and spatially regulated in chicken embryos. At early developmental stages, ADAM13 is expressed in the head mesenchyme, which later develops into the craniofacial skeleton, in the branchial arches, and in the meninges surrounding the brain. Furthermore, ADAM13 mRNA was also detected in several tissues and organs, such as the somites and their derived muscles, the meninges surrounding the spinal cord, the dorsal aorta, the developing kidney, and several digestive organs. Developmental Dynamics 236:862–870, 2007. © 2007 Wiley‐Liss, Inc.
Efficient retrieval of the thermo‐acoustic flame transfer function from a linearized CFD simulation of a turbulent flame
Authors: van Kampen J. F. , Kok J. B. W. , van der Meer Th. H. 
Published: January 2007

AbstractThe stability of thermo‐acoustic pressure oscillations in a lean premixed methane‐fired generic gas turbine combustor is investigated. A key element in predicting the acoustically unstable operating conditions of the combustor is the flame transfer function. This function represents the dynamic relationship between a fluctuation in the combustor inlet conditions and the flame's acoustic response. A transient numerical experiment involving spectral analysis in computational fluid dynamics (CFD) is usually conducted to predict the flame transfer function. An important drawback of this spectral method application to numerical simulations is the required computational effort. A much faster and more accurate method to calculate the transfer function is derived in this paper by using a most important basic assumption: the fluctuations must be small enough for the system to behave linear. This alternative method, which is called the linear coefficient method, uses a linear representation of the unsteady equations describing the CFD problem. This linearization is applied around a steady‐state solution of the problem, where it can consequently describe the dynamics of the system. Finally, the flame transfer function can be calculated from this linear representation. The advantage of this approach is that one only needs a steady‐state solution and linearization of the unsteady equations for calculating a dynamic transfer function, i.e. no time‐consuming transient simulations are necessary anymore. Nevertheless, as a consequence of the large number of degrees of freedom in a CFD problem, an extra order reduction step needs to be performed prior to calculating the transfer function from the linear representation. Still, the linear coefficient method shows a significant gain in both speed and accuracy when calculating the transfer function from the linear representation as compared to a spectral analysis‐based calculation. Hence, this method gives a major improvement to the application of the flame transfer function as a thermo‐acoustic design tool. Copyright © 2007 John Wiley & Sons, Ltd.
On a boundary condition for pressure‐driven laminar flow of incompressible fluids
Authors: Barth William L. , Carey Graham F. 
Published: January 2007

AbstractWe prove in Theorem 1 a new relationship between the stress, pressure, velocity, and mean curvature for embedded surfaces in incompressible viscous flows. This is then used to define a corresponding modified pressure boundary condition for flow of Newtonian and generalized Newtonian fluids. These results agree with an intuitive notion of the flow physics but apparently have not previously been shown rigorously. We describe some of the implementation issues for inflow and outflow boundaries in this context and give details for a penalty treatment of the associated tangential velocity constraint. This is then implemented and applied in high‐resolution 3D benchmark calculations for a representative generalized viscosity model. Copyright © 2007 John Wiley & Sons, Ltd.
Stromal cell‐derived factor‐1 chemokine gene variant in blood donors and chronic myelogenous leukemia patients
Authors: de Oliveira Carlos Eduardo Coral , de Oliveira Cavassin Gabriela Gonçalves , de Lourdes Perim Aparecida , Nasser Thiago Franco , de Oliveira Karen Brajão , Fungaro Maria Helena Pelegrinelli , do Val Carneiro Juliana Laino , Watanabe Maria Angelica Ehara 
Published: January 2007

AbstractChronic myelogenous leukemia (CML) is a malignant myeloproliferative disorder that originates from a pluripotent stem cell expressing the bcr‐abl oncogene. It is characterized by an abnormal release of the expanded, malignant stem cell clone from the bone marrow into the circulation. The stromal cell derived factor‐1 (SDF‐1) gene contains a common polymorphism, termed SDF1‐3′A, in an evolutionarily conserved segment of the 3′ untranslated region (UTR). In this work the SDF‐1 genotypes of 25 patients (9–82 years old) who had been clinically and hematologically diagnosed with CML were compared with those of 60 healthy donors. In addition, the nature of bcr‐abl hybrid mRNA and the association between demographic and hematological parameters were analyzed in cells from 12 CML patients (five women and seven men). All patients underwent blood collection during the chronic phase of disease after they received chemotherapy. b3a2 mRNA was detected in samples from eight of the CML patients and b2a2 mRNA was observed in four cases. An association between basophils and hemoglobin parameters was observed in that hemoglobin levels were higher in b2a2‐expressing patients, and mean basophil levels were higher in patients expressing b3a2. Four of the CML patients (16%) were homozygous for 3′A allele. Of the patients who showed the presence of bcr‐abl transcripts (N = 12), three presented the wt/wt genotype and nine were SDF1‐3′A carriers. Three of the latter were homozygous for this mutation. It is possible that the bcr‐abl fusion gene and the SDF1 genotype for 3′A allele have important implications for the pathogenesis of CML. J. Clin. Lab. Anal. 21:49–54, 2007. © 2007 Wiley‐Liss, Inc.
Utilization of hantavirus antibody results generated over a five‐year period to develop an improved serologic algorithm for detecting acute Sin Nombre hantavirus infection
Authors: Prince Harry E. , Su Xin , Hogrefe Wayne R. 
Published: January 2007

AbstractIn the United States most cases of hantavirus pulmonary syndrome (HPS) are caused by the Sin Nombre virus (SNV) and are typically identified by serology. The goal of this study was to assess the performance of our hantavirus serologic testing algorithm by reviewing results generated over five years. Sera were screened for pan‐hantavirus immunoglobulin (Ig)G and IgM by enzyme‐linked immunosorbent assay (ELISA). Screen IgG+ sera were then tested by immunoblot for SNV glycoprotein‐specific IgG, and screen IgM+ sera were tested for SNV‐specific IgM using an ELISA that measured differential reactivity to SNV and Seoul nucleocapsid proteins. Although only 13% of sera were positive in one or both screening assays, 85% of screen+sera lacked SNV antibodies. Nearly all (97%) screen IgM−IgG+ samples lacked SNV IgG, and 90% of screen IgM+IgG− samples lacked SNV IgM. However, SNV IgM testing of screen IgM+IgG− samples appears to be necessary, since this test identified nine of 37 patients with acute HPS (based on clinical feedback). A screen IgM+IgG+ result was a good predictor of SNV antibody detection and acute HPS. These findings were used to design a modified algorithm that identified all 37 patients with acute HPS, but reduced the number of specimens that required SNV antibody testing by 42%. J. Clin. Lab. Anal. 21:7–13, 2007. © 2007 Wiley‐Liss, Inc.
Chylomicron accelerates C3 tick‐over by regulating the role of Factor H, leading to overproduction of acylation stimulating protein
Authors: Fujita Takayuki , Fujioka Takayuki , Murakami Tetsuo , Satomura Atsushi , Fuke Yoshinobu , Matsumoto Koichi 
Published: January 2007

AbstractAcylation stimulating protein (ASP) is a fragment of the third component of complement (C3) that is generated in the presence of chylomicron, and plays a role in the synthesis of triacylglycerol by transporting free fatty acids into adipocytes. However, the precise mechanism of ASP generation, especially the role of chylomicron in ASP generation, is unknown. We examined the mechanism through which chylomicron induces ASP generation. Ultracentrifugationally separated chylomicron was incubated with normal human serum (NHS) under various conditions, and the amounts of complement activation products and ASP in the incubation mixture were determined by enzyme‐linked immunosorbent assay (ELISA). Upon incubation of NHS with various amounts of chylomicron for 120 min, ASP was generated in a dose‐dependent manner. The time course of the production of ASP was similar to the time course of the C3 tick‐over phenomenon that occurred by depletion of factor H from the serum. The complement activation induced by chylomicron was different from the usual complement activation that occurs under the regulation of factor H and factor I with respect to the time course and the amount of ASP produced. Our results indicate that chylomicron accelerates C3 tick‐over by regulating the role of factor H, leading to the overproduction of ASP. J. Clin. Lab. Anal. 21:14–23, 2007. © 2007 Wiley‐Liss, Inc.
Expression of annual cycles in preen wax composition in red knots: constraints on the changing phenotype
Authors: Reneerkens Jeroen , Piersma Theunis , Damsté Jaap S. Sinninghe 
Published: January 2007

AbstractBirds living in seasonal environments change physiology and behavior in correspondence to temporally changing environmental supplies, demands and opportunities. We recently reported that the chemical composition of uropygial gland secretions of sandpipers (Scolopacidae, order Charadriformes) changes during the breeding season from mixtures of monoesters to diesters, which fulfill specific functions related to incubation. A proper temporal match between the expression of diester preen waxes and incubation requires a flexible organization of the trait. Here we analyze the possible degrees of flexibility with reference to the functionality of better‐understood molt and body mass cycles of free‐living and captive red knots (Calidris canutus). The relative flexibility of seasonal cycles in preen wax composition was examined by two experimental perturbations: (1) giving birds restricted access to food and (2) monitoring them long‐term under a constant photoperiodic regime. We found that wax type cannot change instantaneously, but that changing the type of wax is under similar organizational time constraints as the replacement of feathers. Just as molt and mass cycles, the seasonal rhythm of diester secretion appeared to be under endogenous control: most birds placed in a constant photoperiod still maintained seasonally changing preen waxes. Diester preen wax secretion was synchronized with the peak in body mass in spring, but became less well expressed under constant photoperiodic conditions and when food availability was limited. J. Exp. Zool. 307A:1–13, 2007. © 2007 Wiley‐Liss, Inc.
Dissimilar aggregation processes govern precipitation and gelation of human IgM cryoglobulins
Authors: Vallas Vicky , Farrugia William , Raison Robert L. , Edmundson Allen B. , Ramsland Paul A. 
Published: January 2007

AbstractCryoglobulinemia is associated with a range of diseases including rheumatoid arthritis, B‐cell malignancies, and chronic viral infections. This “cold‐sensitivity” condition is caused by cryoglobulins that precipitate, gel, or occasionally crystallize in the cold. Clinical manifestations vary widely in severity, depending on many factors, including the type of cryoglobulin (monoclonal or mixed immunoglobulins) and the physical nature of the aggregates (precipitate, gel, or crystal). Dynamic light scattering (DLS) was used to examine the cold‐induced precipitation or gelation of two human cryoglobulins, namely, Pot IgM and Yvo IgM. The DLS assay was highly reproducible, sensitive, and had low intra‐assay variations for both IgM cryoglobulins. Distinct processes were revealed to contribute to precipitation and gelation of cryoglobulins. The precipitation of Pot IgM displayed a rapid transition from solution to solid phases, with a wide distribution of aggregate sizes. In contrast, the gelation of Yvo IgM progressed gradually across a broad temperature range to produce a relatively uniform gel matrix. Initial cryoglobulin concentrations determined the kinetics and critical temperatures for both precipitation and gelation. Moreover, the Yvo IgM was observed to have a distinct relationship between concentrations and mean hydrodynamic diameters or particle sizes. Concentration‐dependent effects on particle sizes were present, but not as pronounced for the Pot IgM. Precipitation and gelation of cryoglobulins were also found to be differentially responsive to changes in the aqueous environment. Our results indicate that DLS is a rapid, reliable, and sensitive method for characterizing the nature of disease‐associated cryoglobulins. Copyright © 2007 John Wiley & Sons, Ltd.
Correlation of bladder base elevation with pelvic floor hypertonicity in women with lower urinary tract symptoms
Authors: Chuang Fei‐Chi , Kuo Hann‐Chorng 
Published: January 2007

AbstractAimsTo determine whether the bladder base elevation as revealed by cystogram under fluoroscopy is associated with pelvic floor hypertonicity or bladder outlet obstruction (BOO) in women.MethodsSixty‐two women who were referred to our videourodynamic laboratory for assessment of lower urinary tract symptoms (LUTS) were included in this retrospective analysis. Thirty‐one of these women with bladder base elevation—revealed by cystogram under fluoroscopy during videourodynamic study—served as the experimental group, and another group of 31 women without bladder base elevation served as control. None of the patients had neuropathy, previous pelvic surgery or chronic urinary retention. The clinical symptoms, urodynamic diagnosis, and parameters were compared between the two groups.ResultsThe mean voiding pressure (Pdet.Qmax) and postvoid residual (PVR) were significantly greater, and maximum flow rate (Qmax) and voided volume were significantly lower in the bladder base elevation group. When a Pdet.Qmax of ≥35 cmH2O combined with a Qmax of ≤15 ml/sec in pressure flow study was used to diagnose BOO, significantly more patients in the bladder base elevation group had BOO than controls (51.6% vs. 9.7%, P = 0.0003). Pelvic floor muscle electromyogram (EMG) was dyscoordinated during the voiding phase in 18 (58.1%) and 9 (29%) of the patients with and without bladder base elevation, respectively (P = 0.0212).ConclusionWomen with LUTS and bladder base elevation revealed in the filling phase of videourodynamic study had significantly higher voiding pressure and incidence of dyscoordinated pelvic floor EMG activities during voiding, suggesting a higher incidence of BOO and pelvic floor hypertonicity. Neurourol. Urodynam. 26:502–506, 2007. © 2007 Wiley‐Liss, Inc.
Managing end‐to‐end quality of service in multiple heterogeneous wireless networks
Authors: Ahluwalia Punit , Varshney Upkar 
Published: January 2007

AbstractSupporting quality of service (QoS) in wireless networks has been a very rich and interesting area of research. Many significant advances have been made in supporting QoS in single wireless networks. However, the support for QoS across multiple heterogeneous wireless networks will be required in future wireless networks. In connections spanning multiple wireless networks, end‐to‐end QoS will depend on several factors such as mobility patterns, connection patterns, and the QoS policies in each of the networks. In this paper, we present an architecture for multiple heterogeneous wireless networks, several QoS schemes, a simulation model and several interesting results. The simulation model can evaluate the QoS performance under a variety of network configurations, user and mobility types, and network resources. Our results show that end‐to‐end QoS depends on several factors, including system utilization, mobility levels, and the individual QoS schemes implemented in individual networks. We also show how the QoS ideas presented in this paper can be used by wireless carriers for improved QoS support and management. Copyright © 2006 John Wiley & Sons, Ltd.
Die kinematisch erzwungene Schwingungen der Fußgängerbrücke
Authors: Mironowicz Władysław , Zaja̧c Tomasz 
Published: January 2007

AbstractIn der Arbeit werden die kinematisch erzwungenen Stochastischschwingungen schwanker Konstruktionen behandelt, zu denen Fußgängerbrücken gehören. Solche Objekte sind empfindlich gegen dynamische eingehende Wirkung, und darunter auf die Bewegung des Untergrundes z. B. das Erdbeben, der bergmännischen Gebirgsschlag. Aus praktischen Gründen wurde angenommen, dass die Nutzmasse des Objektes, und die kinematische Belastung die Schicksalsmerkmale haben. Dargestellt wurde die allgemeine Problemlösung bei dem Gebrauch der Korrelation‐Theorie. Die ausführliche numerische Analyse ist für die Fußgängerbrücke durchgeführt, in Gestalt von Raumrohrfachwerk. Man hat die verschiedenen Montagestände geprüft, und verschiedene Arten der Gerüste: aus Stahlbeton, Stahl und Holz. (© 2006 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Hypergeometric Summation Techniques for High Order Finite Elements
Authors: Pillwein V. , Paule P. , Schneider C. , Schöberl J. 
Published: January 2007

AbstractThe goal of this paper is to discuss the application of computer algebra methods in the design of a high order finite element solver. The finite element method is nowadays the most popular method for the computer simulation of partial differential equations. The performance of iterative solution methods depends on the condition number of the system matrix, which itself depends on the chosen basis functions. A major goal is to design basis functions minimizing the condition number, and which can be implemented efficiently. A related goal is the application of symbolic summation techniques to derive cheap recurrence relations allowing a simple and efficient implementation of basis functions. (© 2006 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Topology Optimization Procedure Based on Structure Stress History
Authors: Kutylowski Ryszard 
Published: January 2007

AbstractThe structure design points stress analysis for succeeding optimization steps is the base of the topology optimization algorithm. Because the material density of the material is proportional to the strain energy we can predict how to change the density for each design point for the next optimization steps. Proposed procedure make the optimization process faster and final topology is finally more optimal than topology obtained using standard optimization procedures. This stress analyzing procedure, can be treated as a hardware of the sensors being the part of the smart structure for the real time structure reconstruction. (© 2006 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Some New Developments in ILU Preconditioners
Authors: Mayer Jan 
Published: January 2007

AbstractILUC, a Crout‐based Gaussian elimination incomplete LDU‐factorization preconditioner, can be improved for some matrices by pivoting by columns and by interchanging rows for better sparsity. Just as many other ILU‐type preconditioners, this can implemented in a multilevel framework and combined with various dropping strategies. (© 2006 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Numerical solution of turbulent flow in a turbine cascade
Authors: Kozel Karel , Louda Petr , Příhoda Jaromír 
Published: January 2007

AbstractThe work deals with numerical modeling of subsonic and transonic flow through the SE1050 turbine cascade. AUSM and AUSMPW+ splitting is used for inviscid fluxes. The turbulence is modelled usind SST and EARSM turbulence model. The time integration method is backward Euler (implicit). Interaction of shock wave with turbulence models is observed. The results are compared with measurements. (© 2006 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Block and joint ℋ︁‐matrix preconditioners for the Oseen equations
Authors: Le Borne Sabine 
Published: January 2007

AbstractFor saddle point problems in fluid dynamics, many preconditioners in the literature exploit the block structure of the problem to construct block diagonal or block triangular preconditioners. The performance of such preconditioners depends on whether fast, approximate solvers for the linear systems on the block diagonal as well as for the Schur complement are available. We will construct these efficient preconditioners using hierarchical matrix techniques in which fully populated matrices are approximated by blockwise low rank approximations. We will compare such block preconditioners with those obtained through a completely different approach where the given block structure is not used but a domain‐decomposition based ℋ︁‐LU factorization is constructed for the complete system matrix. Preconditioners resulting from these two approaches will be discussed and compared through numerical results. (© 2006 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
FE‐discretizations of mixed elliptic‐parabolic PDEs
Authors: Stiemer Marcus 
Published: January 2007

AbstractThe purpose of this work is to examine the regularity of solutions to mixed elliptic‐parabolic boundary value problems. Based on this analysis, estimates on the convergence rate of standard Galerkin discretizations for such problems are given. (© 2006 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)