bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design of a multiple criteria decision analysis framework for prioritizing high-impact health technologies in a regional health service
Authors: Sánchez-Martínez Fernando-Ignacio , Abellán-Perpiñán José-María , Martínez-Pérez Jorge-Eduardo , Gómez-Torres Jorge-Luis 
Published: April 2024

Abstract

Objectives
This study aims to develop a framework for establishing priorities in the regional health service of Murcia, Spain, to facilitate the creation of a comprehensive multiple criteria decision analysis (MCDA) framework. This framework will aid in decision-making processes related to the assessment, reimbursement, and utilization of high-impact health technologies.

Method
Based on the results of a review of existing frameworks for MCDA of health technologies, a set of criteria was proposed to be used in the context of evaluating high-impact health technologies. Key stakeholders within regional healthcare services, including clinical leaders and management personnel, participated in a focus group (n = 11) to discuss the proposed criteria and select the final fifteen. To elicit the weights of the criteria, two surveys were administered, one to a small sample of healthcare professionals (n = 35) and another to a larger representative sample of the general population (n = 494).

Results
The responses obtained from health professionals in the weighting procedure exhibited greater consistency compared to those provided by the general public. The criteria more highly weighted were “Need for intervention” and “Intervention outcomes.” The weights finally assigned to each item in the multicriteria framework were derived as the equal-weighted sum of the mean weights from the two samples.

Conclusions
A multi-attribute function capable of generating a composite measure (multicriteria) to assess the value of high-impact health interventions has been developed. Furthermore, it is recommended to pilot this procedure in a specific decision context to evaluate the efficacy, feasibility, usefulness, and reliability of the proposed tool.
Impact of electrophysiologists at daily multidisciplinary report in a paediatric cardiac care unit
Authors: Mikulski Matthew F. , Well Andrew , Shmorhun Daniel , Mery Carlos M. , Fenrich Arnold L. , Fraser Charles D. 
Published: April 2024

AbstractBackground:Paediatric cardiac electrophysiologists are essential in CHD inpatient care, but their involvement is typically limited to consultation with individual patients. In our integrated heart centre, an electrophysiologist reviews all cardiac inpatient telemetry over the preceding 24 hours and participates in daily multidisciplinary morning report. This study investigates the impact of the strategy of consistent, formalised electrophysiologist presence at multidisciplinary morning report.Methods:This is a single-centre, prospective, observational study of electrophysiologist participation in patient encounters during heart centre multidisciplinary morning report from 10/20/2021 to 10/31/2022. Multidisciplinary morning report includes discussion of all intensive care and non-intensive care cardiac patients. An encounter was defined as reporting on one patient for one day. Electrophysiologists were initially blinded to observations.Results:Two electrophysiologists were observed over 215 days encompassing 6413 patient encounters. Electrophysiologists made comments on 581(9.1%) encounters in 234 unique patients with diverse diagnoses, equating to a median of 3[interquartile range:1–4] encounters per day. These included identifications of arrhythmias and describing electrocardiographic findings. Recommendation to change management occurred in 282(48.5%) encounters, most commonly regarding medications (n = 142, 24.4%) or pacemaker management (n = 48, 8.3%). Of the 581 encounters, there were 61(10.5%) in which they corrected another physician’s interpretation of rhythm or electrocardiogram.Conclusion:Routine electrophysiologist involvement in multidisciplinary morning report provides significant, frequent, and timely input in patient management by identifying precise rhythm-related diagnoses and allowing nuanced, patient-specific medication and pacemaker management of all cardiac patients, not just those consulted. Electrophysiologist presence at multidisciplinary morning report is a vital resource and this practice should be considered at integrated paediatric cardiac centres.
Bandpass filter with multiple selective absorptive stopbands for 28 GHz transmitters
Authors: Moscato Stefano , Caicedo Steven , Oldoni Matteo 
Published: April 2024

AbstractThis manuscript presents a novel design for an absorptive bandpass filter for mm-wave applications, specifically the commercial FR2 spectrum. Three bands have been selected to be properly input matched with only one of them being the passband, where the insertion loss is minimized. The proposed approach relies on a multiplexer topology implemented through microstrip lines and on thin-film manufacturing process on alumina to shrink the footprint. Cascades of half-wavelength C-shape open-ended resonators are exploited to create the matched bands and define the filter’s selectivity. The selected passband spans from 26.5 to 28.5 GHz, with a measured maximum insertion loss of 3.05 dB for a −3 dB fractional bandwidth of 7.3%. Two absorptive bands are realized to match signals at 24 and 32.25 GHz. The alumina die footprint is 5500 × 3440 µm2, compatible with immediate integration within a mm-wave lineup.
Potential Barriers to Adaptive Actions in Water–Rice Coupled Systems in Japan: A Framework for Predicting Soft Adaptation Limits
Authors: Takada Asari , Yoshida Takeo , Ishigooka Yasushi , Maruyama Atsushi , Kudo Ryoji 
Published: April 2024

AbstractThe changing climate makes it more difficult to manage water resources and food production sustainably. Various adaptation measures have been proposed to moderate the negative impacts of climate change; however, implementation of these measures may be hampered by other factors even if the benefits are acknowledged—a situation termed “soft adaptation limits” by the IPCC. We hypothesized that societal rules can be a potential barrier to adaptive action if they are too fixed, because such rules have coevolved with the interactions between the past climate and human activities. To test this hypothesis, we present a framework based on the assumption that associated societal rules of Japan's matured irrigation systems are potential barriers to adaptation. The framework consisted of two process‐based models, one to evaluate the water deficit risk and one to evaluate the benefits of optimizing rice yield and quality. We applied each model to an experiment in which we shifted the current transplantation date by 1 week for up to 5 weeks before and after the current date under the historical (1981–2000) and RCP 2.6 and 8.5 (2011–2030 and 2031–2050) scenarios. We revealed two contrasting development pathways in the study watershed. Soft adaptation limits imposed by water availability will occur by 2030 if farmers optimize for quality, whereas mutual benefits to farmers and river administrators will be achieved if farmers seek yield. We argue that more participatory research with stakeholder engagement, as well as policy discussions about these possible developments, is needed to ensure successful adaptation.
Stochastic Assessment of Dissolution at Fluid‐Mineral Interfaces
Authors: Recalcati Chiara , Siena Martina , Riva Monica , Bollani Monica , Guadagnini Alberto 
Published: April 2024

AbstractChemical weathering associated with dissolution/precipitation at interfaces between minerals and flowing fluids is key for the evolution of geologic systems, including groundwater contamination and storage capacity. Relying on Atomic Force Microscopy (AFM) yields reaction rates at nanoscale resolutions. Challenges limiting our ability to quantify heterogeneity associated with these processes include establishing reliable platforms allowing AFM imaging of real‐time and in situ absolute material fluxes across mineral surfaces under continuous flow conditions to complement typically acquired surface topography images. We provide an experimental workflow and heterogeneous absolute rates at the nanoscale across the surface of a calcite crystal under dissolution. These high‐quality experimental observations are then interpreted through a stochastic approach. The latter is geared to embed diverse kinetic modes driving the degree of spatial heterogeneity of the reaction and corresponding to different mechanistic processes documented across the crystal surface.
The Third Plasma Density Peak at Poleward of EIA Crest: Swarm and ICON Observations
Authors: Huang Yuyang , Xiong Chao , Wan Xin , Park Jaeheung , Spogli Luca 
Published: April 2024

AbstractIn this study, we focus on the presence of the ionospheric third plasma density peak associated with the equatorial ionization anomaly (EIA) based on observations from the ESA's Swarm constellation. By statistically analyzing the third peaks observed by the Swarm A and B at two different altitudes, we found that such structure appears mainly around ±20° magnetic latitude (Mlat), namely the poleward of the EIA crests. In the meanwhile, the third peak shows prominent season and local time dependences, that are mainly observed in the summer hemisphere during solstice seasons and with the highest occurrence in the afternoon hours. However, no clear solar flux and magnetic activity dependences are found. By further analyzing the simultaneous neutral wind measurements from the ionospheric connection explorer satellites, we found that the summer‐to‐winter hemispheric meridional wind is responsible for causing the third peak as well as its seasonal dependence (higher occurrence in the summer hemisphere). In addition, the third‐peak structure shows prominent longitudinal dependence. In regions where the magnetic declination directs eastward, it has a larger occurrence in the southern hemisphere, while in regions where the magnetic declination reverses, it has a larger occurrence in the northern hemisphere. Such a longitudinal dependence suggests that the zonal wind, which has a magnetic field‐aligned component at favorable magnetic declination regions, contributes also to the formation of the third‐peak structure.
Detailed 3D Structures of the Western Edge of the Pacific Large Low Velocity Province
Authors: Li Jiewen , Zhang Baolong , Sun Daoyuan , Tian Dongdong , Yao Jiayuan 
Published: April 2024

AbstractLarge Low Velocity Provinces (LLVPs) are situated oppositely in the lowermost mantle beneath the Pacific Ocean and Africa. Deciphering the detailed seismic structures at the edge of LLVPs can provide key information on the composition and dynamics in the deep Earth. Here, we provide a detailed seismic image at the western edge of the Pacific LLVP by dense recordings. Differential travel time residuals and amplitude ratios between ScS and S outline the S‐wave western boundary of the Pacific LLVP, suggesting the complex structures including low/high‐velocity patches in the lowermost mantle in our study region. We determine the 3D low‐velocity structure by modeling the delayed ScS and high‐velocity D″ layer structure by modeling the anomalous Scd, with tight constraints from multiple events data. The drastically varied waveforms in azimuth suggests a sharp transitional boundary among the complex structures. After comparing the velocity structures in adjacent regions, we propose that the 3D structures of the western edge of the Pacific LLVP are strongly influenced by the vigorous mantle flow associated with the actively subducted slab.
Coarse Sand Transport Processes in the Ripple Vortex Regime Under Asymmetric Nearshore Waves
Authors: Fritsch N. , Fromant G. , Hurther D. , Cáceres I. 
Published: April 2024

AbstractLarge‐scale wave flume experiments are conducted in the ripple vortex regime to study near bed coarse sand transport processes below asymmetric surface waves typical of the coastal nearshore region. For this purpose, a set of complementary acoustic instruments were deployed under regular nearshore wave conditions. Time‐resolved velocity, sand concentration and sand flux profiles are measured across both the dense bedload and dilute suspension layers with an Acoustic Concentration and Velocity Profiler. The equilibrium 2D suborbital ripples are in good agreement in terms of dimensions, shape and onshore migration rate with Wang and Yuan (2018, https://doi.org/10.1029/2018jc013810, 2020, https://doi.org/10.1016/j.coastaleng.2019.103583). Stoss ripple vortex entrainment around the trough‐to‐crest flow reversal (FR+) is found to be more energetic in terms of sand pick‐up into suspension compared to the counter rotating lee side vortex around the FR‐ flow reversal, as a consequence of the onshore skewed wave acceleration. Ripple vortex driven nearbed velocity phase leads around both flow reversals exceed typical bed friction induced values found in turbulent Wave Boundary Layers. Intrawave sand erosion events can be distinguished locally at the two ripple vortex positions around the flow reversals and two events more uniformly distributed along the ripple profile at wave crest and trough. Spatial fields of sand flux reveal the origin of the net onshore directed suspended and bedload transport. Good agreement is found with the mechanism identified under asymmetric oscillatory flows in Wang and Yuan (2020, https://doi.org/10.1016/j.coastaleng.2019.103583). Differences with ripple vortex regime under skewed shoaling waves and symmetric oscillatory flows are highlighted.
Differentiating Periodic Drivers of Air Quality Changes: A Two‐Step Decomposition Approach Integrating Machine Learning and Wavelet Analysis
Authors: Song Yuqin , Wu Hao , Dai Qili , Liu Xuan , Zhang Yufen , Feng Yinchang 
Published: April 2024

AbstractAir quality time series exhibit significant periodic patterns, which are linked to a diverse array of emission sources and atmospheric processes. To discern and distinguish these periodic drivers, we have devised a two‐step decomposition approach that integrates a machine learning‐based model for weather normalization with Morlet wavelet analysis. This approach was applied to a 7‐year data set encompassing six regulated air pollutants across eight Chinese cities. Our analysis revealed distinct periodicities in weather‐normalized concentrations of primary air pollutants: a dominant annual cycle with periodicity around 365 days, which accounts for over 50% of the variance on average and is primarily driven by recurrent winter heating activities; daily cycles characterized by regular diurnal patterns attributable to combustion sources such as traffic; and periodicities exceeding 512 days that associated with long‐term regulatory policies targeting SO2. Particularly notable was the significant drop in the strength of the annual cycle in northern cities following the implementation of China's clean heating policies in 2017/2018, affirming the success of these initiatives. Additionally, diurnal dispersion and photochemistry, large‐scale atmospheric circulation, and synoptical weather patterns are likely responsible for the observed daily cycle (accounting for over 40% of the variance), annual periodicities, and intra‐monthly variations in the meteorologically driven concentrations, respectively. The varying power of these periodic drivers across time and locations implies the heterogeneity of emission rates and region‐specific climates. This work highlights the efficacy of this decomposition approach in air quality research, warranting attention for its potential value for enhancing our understanding of air pollution dynamics.
Magmatic, Metamorphic and Structural History of the Variscan Lizard Ophiolite and Metamorphic Sole, Cornwall, UK
Authors: Mackay‐Champion Tobermory C. , Searle Michael P. , Tapster Simon , Roberts Nick M. W. , Shail Robin K. , Palin Richard M. , Willment George H. , Evans Josh T. 
Published: April 2024

AbstractThe Lizard ophiolite, Cornwall, South‐West England, is the largest and best‐preserved ophiolite within the Variscan orogenic belt. It forms part of the Rheic‐Rhenohercynian suture zone, and was obducted northwestward onto the passive continental margin of Avalonia (Laurussia) during the Middle Devonian. It comprises an almost complete thrust slice of oceanic crust with sheeted dykes, gabbros, Moho transition sequence, and upper‐mantle peridotites, underlain by a metamorphic sole. Despite the importance of the Lizard ophiolite in understanding Variscan tectonics, the origin and age of the Lizard ophiolite are debated. We present new field observations, structural maps and cross‐sections of the Lizard ophiolite from extensive re‐mapping, integrated with U–Pb geochronology, petrology, thermobarometry, and whole rock geochemistry. We report new U–Pb zircon (CA‐ID‐TIMS and LA‐ICPMS) ages of 386.80 ± 0.25/0.31/0.52 Ma (Givetian) from a plagiogranite dyke intruding the Crousa Gabbros at Porthoustock, and 395.08 ± 0.14/0.22/0.47 Ma (Emsian) from partial melts of the metamorphic sole Landewednack Amphibolites at Mullion Cove. These ages, respectively, precisely date the formation of the Lizard ophiolite oceanic crust, and the age of cooling post peak‐metamorphism of the sole. Petrological modeling on the Landewednack Amphibolites suggests peak metamorphic conditions of 10 ± 2 kbar and 600 ± 75°C. We demonstrate that the Lizard ophiolite formed as a supra‐subduction zone ophiolite overlying an inverted metamorphic sole, and we combine our observations and data into a new geodynamic model for the formation and obduction of the ophiolite. The current data supports an induced subduction initiation model.
The demineralization resistance and mechanical assessments of different bioactive restorative materials for primary and permanent teeth: an in vitro study
Authors: Ibrahim Maria Salem , Aldhafeeri Fahad Rakad , Banaemah Abdullah Sami , Alhaider Mana S. , Al-Dulaijan Yousif A. , Balhaddad Abdulrahman A. 
Published: April 2024

Abstract
Objectives
This article examines the efficacy of two bioactive dental composites in preventing demineralization while preserving their mechanical and physical properties.

Materials and methods
The study compares Beautifil Kids and Predicta® Bioactive Bulk-Fill (Predicta) composites with conventional dental composite. Flexural strength and elastic modulus were evaluated using a universal testing machine. A pH-cycling model assessed the composites’ ability to prevent dentin demineralization. Color stability and surface roughness were measured using a spectrophotometer and non-contact profilometer, respectively, before and after pH-cycling, brushing simulation, and thermocycling aging.

Results
Beautifil Kids exhibited the highest flexural strength and elastic modulus among the materials (p < 0.05). Predicta demonstrated the highest increase in dentin surface microhardness following the pH-cycling model (p < 0.05). All groups showed clinically significant color changes after pH-cycling, with no significant differences between them (p > 0.05). Predicta exhibited greater color change after brushing and increased surface roughness after thermocycling aging (p < 0.05). While Beautifil Kids had higher surface roughness after pH-cycling (p < 0.05).

Discussion/Conclusion
Bioactive restorative materials with ion-releasing properties demonstrate excellent resistance to demineralization while maintaining mechanical and physical properties comparable to the control group.
Addition of ruxolitinib to standard graft-versus-host disease prophylaxis for allogeneic stem cell transplantation in aplastic anemia patients
Authors: Zhang Xiaoyu , Zhao Xiaoli , Chen Shulian , Hao Mengze , Zhang Lining , Gong Ming , Shi Yuanyuan , Wei Jialin , Zhang Ping , Feng Sizhou , He Yi , Jiang Erlie , Han Mingzhe 
Published: April 2024

AbstractAllogeneic hematopoietic stem cell transplantation (allo-HSCT) offers rapid hematopoietic and immune reconstitution for aplastic anemia (AA). As a non-malignant disorder, attenuation of GVHD remains a clinical priority in AA patients. Our study sought to investigate the safety and efficacy of the prophylactic use of ruxolitinib in allogeneic HSCT. A total of 35 AA patients were retrospectively consecutively treated with allo-HSCT whereby ruxolitinib was added to the standard GVHD prophylaxis regimen (rux group). The addition of peri-transplant ruxolitinib did not impact the engraftment and graft function, while better recovery of CD4+ Tregs in the rux group was observed. Interestingly, the rux group demonstrated significantly lower incidence of bacterial/fungal infections (17.14% vs 45.71%). Compared to the control group, the rux group exhibited significantly lower incidence of moderate to severe aGVHD (17.1% vs 48.6%) with a trend toward lower severe aGVHD (8.6% vs 20%) and cGVHD (26.2 vs 38.3). The rux group also demonstrated a trend toward higher GVHD and failure-free survival (GFFS: 85.7% vs 68.6%) and lower TRM (2.9% vs 14.3%). Addition of ruxolitinib to standard GVHD prophylaxis regimen, thus, represents a safe and highly efficient method for the attenuation of GVHD with better outcome of allo-HSCT.
Optical and clinical simulated performance of a new refractive extended depth of focus intraocular lens
Authors: Alarcon Aixa , del Aguila Carrasco Antonio , Gounou Franck , Weeber Henk , Cánovas Carmen , Piers Patricia 
Published: April 2024

Abstracts
Objectives
The purpose of this study is to evaluate the optical and expected clinical performance of a new refractive Extended Depth of Focus (EDF) intraocular lens (IOL), TECNIS PureSee™ IOL, designed to maintain a monofocal-like dysphotopsia profile.

Methods
Simulated visual acuity (sVA) with varying defocus was calculated using the area under the Modulation Transfer Function measured in an average eye model and from computer simulations in eye models with corneal higher-order aberrations. Tolerance to defocus was evaluated using computer simulations of the uncorrected distance sVA under defocus. To evaluate the dysphotopsia profile, halo pictures obtained using an IOL-telescope, as well as simulated images in a realistic eye model under defocus were assessed. The results of the refractive EDF, TECNIS PureSee™ IOL, were compared to those of a diffractive EDF, TECNIS Symfony™ IOL, of the same platform.

Results
The refractive EDF IOL provides similar range of vision to the diffractive EDF IOL with the same distance, and similar intermediate and near sVA. The refractive EDF IOL provides the same tolerance to hyperopia as the diffractive EDF but more tolerance to myopia. Halo pictures and simulations showed that the refractive EDF provides comparable dysphotopsia profile to the monofocal IOL and better than the diffractive EDF.

Conclusions
The results of this preclinical study in clinically relevant conditions show that the new refractive EDF IOL is expected to provide similar range of vision to the diffractive IOL of the same platform and higher tolerance to refractive errors. The refractive EDF provides a dysphotopsia profile that is better than the diffractive EDF and comparable to that of the monofocal IOL, also in the presence of residual refractive errors.