bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reticuloendothelial system (RES) hyperfunction and erythropoietin (Ep) production in the regenerating liver
Authors: Naughton B. A. , Birnbach D. J. , Liu P. , Kolks G. A. , Tung M. Z. , Piliero J. A. , Piliero S. J. , Gordon A. S. 
Published: February 2007

AbstractHepatic cells in rats were evaluated after subtotal hepatectomy using scintillation scanning with technetium sulfur colloid (TSC), autoradiography, and microstereology techniques. The ability of the liver to accumulate TSC increased during the course of the regeneration as did the labeling of Kupffer and parenchymal cells with tritiated thymidine (3H‐tdR). Kupffer to parenchymal cell number ratios and Kupffer cell relative areas were also elevated, attaining peak values at 72 hours post‐hepatectomy. This period corresponds to the time of peak erythropoietin (Ep) production in rats with regenerating livers after nephrectomy and exposure to hypoxia. These findings suggest that the Kupffer cell may function as a cellular site of Ep formation.
Prognostic value of pre‐treatment lymphocyte count and T cell levels in localized bronchogenic carcinoma
Authors: Dellon A. L. , Potvin C. , Chretien P. B. 
Published: February 2007

AbstractIn the patient with clinically localized bronchogenic carcinoma, the pretreatment peripheral blood lymphocyte count and the thymus‐dependent lymphocyte (T cell) level correlated with the prognosis if the tumor histology was either squamous cell, oat cell, or undifferentiated carcinoma. Patients whose pre‐treatment lymphocyte count was less than 1,000/ml or whose T cell level was less than 750/ml either died or developed distant metastases by nine months after treatment of their localized tumor. By contrast, 55% of patients whose pre‐treatment T cell level was greater than 750/ml were alive and without evidence of metastases nine months after treatment (P < 0.02). Analysis of survival of these patients by the life‐table method through the first post‐treatment year further demonstrates the prognostic value of a low pre‐treatment lymphocyte count or T cell level. The pretreatment lymphocyte count and T cell level in patients with adenocarcinoma did not correlate with prognosis.
Adriamycin in localized and metastatic uterine sarcomas
Authors: Piver M. Steven , Barlow Joseph J. , Lele Shashikant B. , Yazigi Roberto 
Published: February 2007

AbstractSeventeen women with metastatic uterine sarcomas were treated with Adriamycin chemotherapy. Only one (6%) had an objective response. In addition, 12 patients with early uterine sarcomas were randomized to Adriamycin versus no adjuvant chemotherapy in order to evaluate the effect of Adriamycin in reducing the incidence of subsequent distant recurrences. Of those women receiving Adriamycin, two developed distant metastasis and two developed life‐threatening congestive heart failure. Also, two of the six women who did not receive Adriamycin developed distant metastasis. Therefore, continuation of the randomized trial was considered unjustified.
Effect of metyrapone and aminoglutethimide on the murine sarcoma (MuSV‐M) and breast adenocarcinoma (C3HBA)
Authors: Seifter E. , Critselis A. N. , Levenson S. M. , Rettura G. 
Published: February 2007

AbstractIn previous studies with C3HBA tumors in C3H mice and with murine sarcoma virus tumors (MuSV‐M) in several varieties of mice, it was shown that administration of cortisone acetate or infliction of stressors that were presumed to cause increased secretion of adrenal glucocorticoids increased the severity of the tumor diseases. The administration of physiologic doses of estradiol did not influence the growth of these two tumors. We, however, had found that administration of metyrapone (MET) inhibits the growth of these tumors. We had attributed its action to 1) a decrease in corticosterone production and 2) an increase in 11 deoxycorticosterone production. To determine which of these factors was more important we compared the action of MET to aminoglutethimide (AG), since AG decreases both corticosterone and deoxycorticosterone levels.Experimental diets containing MET (200 mg/kg) or AG (120 mg/kg) were fed to CBA and C3H mice, starting three days prior to their inoculation with a 1 × 10−1 and 1 × 10−2 gr eq/ml concentration of MuSV‐M or 1 × 105 and 1 × 106 C3HBA cells, respectively. In the MuSV‐M system, MET lengthened the latency period of tumor development, inhibited tumor incidence, decreased tumor score, and shortened tumor regression time. In the C3HBA system, MET had a similar inhibiting effect on tumor growth. In contrast, AG had no statistically significant antitumor effect in either the MuSV‐M or C3HBA systems.We interpret these data as supporting the view that the antitumor effect of MET is due to an accumulation of deoxycorticosterone and a diminution of glucocorticoids because of the selective actions of MET on 11β‐steroid hydroxylase.
Fine‐needle biopsy of thyroid gland
Authors: Bodo M. , Döbrössy L. , Sinkovics I. , Tarján G. , Daubner K. 
Published: February 2007

AbstractCritical analysis is provided by the authors on cytologic examination combined with histology of 131 patients with thyroid alterations. Cytologic examination yielded seven false‐negative and four false‐positive findings. Sensitivity of the procedure was 0.78 and the specificity 0.97. Aspiration cytology of the thyroid gland combined with other methods of examination can be considered an advance in the diagnostics of thyroid diseases.
Predictive value of plasma CEA in patients with colorectal carcinoma
Authors: Koch M. , McPherson T. A. 
Published: February 2007

AbstractTwo years follow‐up of 46 patients with colorectal carcinoma resected “for cure” shows that of the nine patients with an elevated (<5 ng/ml) CEA plasma titer one to six months after surgery, only one, or 11%, had remained disease free. Of the 38 patients with normal (<5 ng/ml) plasma CEA, 27, or 71%, were free of disease two years after surgery. In another 85 patients presenting six months to ten years after resection “for cure” of their colorectal carcinoma, normal CEA levels were found in 73, and only five, or 6.4%, of these presented with disease progression when followed for two years; of the 12 patients that presented with CEA values >5 ng/ml, disease progression was evident in eight or 67%; in eight patients with CEA levels of >10 ng/ml, the proportion of patients with disease progression increased to 87.5% (7/8).When a patient with a history of colorectal cancer, but seemingly free of disease, presents with levels not only repeatedly above normal (>5 ng/ml) but above the levels found in some nonmalignant conditions (>10 ng/ml), thorough re‐examination of the patient to locate the site of possible disease progression is indicated. In 14 such patients further diagnostic methods showed local recurrences in four, metastasis limited to the liver in six, and other metastasis in four.In conclusion, in patients with colorectal carcinoma post operative elevated CEA plasma levels are a sign of poor prognosis. Consistently elevated CEA levels (> 10 ng/ml) are a stong indication of disease progression.
Ultrastructural localization of lactic dehydrogenase in mouse mammary carcinoma cells
Authors: Ghosh Bimal C. , Ghosh Luna , Boarini Marla , Newson Bobbie , Das Gupta Tapas K. 
Published: February 2007

AbstractElectron microscopic study of lactic dehydrogenase (LDH) was carried out in C3H mouse mammary carcinoma cells. Scattered cytoplasmic LDH granules were noted as well as around mitochondria and nuclear membrane. Control studies with normal breast tissues failed to show any activity. This observation suggests that LDH plays an important role in C3H mammary carcinoma and may be of use as an additional marker.
Chemoimmunotherapy with or without oophorectomy in premenopausal patients with advanced breast cancer
Authors: Yap Hwee‐Yong , Hortobagyi Gabriel N. , Blumenschein George R. , Tashima Charles K. , Buzdar Aman U. , Krutchik Allan N. , Benjamin Robert S. , Gutterman Jordan U. , Bodey Gerald P. 
Published: February 2007

AbstractNinety‐eight premenopausal patients with stage IV breast cancer were treated with chemoimmunotherapy alone, or with combination oophorectomy – chemoimmunotherapy either simultaneously (chemoimmunotherapy within four weeks of oophorectomy) or sequentially (delayed chemoimmunotherapy until evidence of progressive disease or no response to oophorectomy). The chemoimmunotherapy consisted of a three‐drug combination of Adriamycin, cyclophosphamide, and 5‐fluorouracil or Ftorafur; immunotherapy consisted of either oral levamisole, BCG by scarification, or a combination of both.Forty patients underwent simultaneous oophorectomy–chemoimmunotherapy, with a response rate of 85% and a median duration of response of 25 months. Response rate of 69% and a median duration of response of 16.6 months was observed with the 29 patients who received sequential oophorectomy–chemoimmunotherapy. Another 29 patients were treated with chemoimmunotherapy alone and achieved a response rate of 87% and a median duration of response of 11.8 months.Though there were no significant differences in the response rate, patients treated with chemoimmunotherapy alone had a significantly shorter median duration of response (P < 0.05). This would suggest that oophorectomy in combination with chemoimmunotherapy is the most favorable treatment modality for premenopausal patients with advanced metastatic breast cancer.
Immune suppression by cultured lymphocyte supernates of tumor‐bearing hosts
Authors: Svedersky Lloyd P. , Dodd Matthew C. , Minton John P. 
Published: February 2007

AbstractA nonspecific immunosuppressive factor produced by lymphocytes of tumor‐bearing hosts has been demonstrated. A modified Jerne plaque technique was used to quantify IgM antibody production of sheep erythrocyte‐immune Swiss mouse lymphocytes (IL). Significant suppression of IgM antibody production was found when IL were treated with cultured lymphocyte supernates of 4198 fibrosarcoma‐bearing mice. The suppressive activity was found to be significant six days prior to any visible tumor development, and, through the use of glass and nylon wool columns, appears to be produced by T cells. Similar immunosuppressive activity was found in 22 cancer patients tested as above, compared either to 16 patients who previously had had solid tumors but are now without clinical disease or to 19 normal controls.
Patterns of spontaneous metastasis manifested by three rat prostate adenocarcinomas
Authors: Pollard Morris , Luckert Phyllis H. 
Published: February 2007

AbstractThree transplantable rat prostate adenocarcinoma cell lines were assessed for patterns of metastasis, ie, routes of dissemination and target organ(s) selected for implantation. Two lines (I and III) were disseminated only through ipsilateral lymphatic channels to the lungs. The third cell line (II) was disseminated through lymphatic and blood channels to lungs, liver, and kidneys. The pattern of spontaneous metastasis is a characteristic of the tumor cell; but there is evidence that the rate and extent of metastasis can be modified experimentally.
Spindle and giant cell carcinoma of the thyroid: Report of a five‐year survival after lobectomy and postoperative irradiation
Authors: Spiro Ronald H. , Daniello Nicholas 
Published: February 2007

AbstractWe have described a patient who remains alive and well five years after lobectomy and planned postoperative irradiation for a sizable spindle and giant cell carcinoma arising in the right thyroid lobe which was adherent to the trachea and the esophagus. The dismal experience of others with this highly lethal tumor has been reviewed. A trial of surgical resection and fulldose postoperative teletherapy seems warranted in selected patients who have a resectable tumor.
Intraarterial adriamycin in the treatment of soft tissue sarcomas
Authors: Karakousis C. P. , Lopez R. , Catane R. , Rao U. , Moore R. , Holyoke E. D. 
Published: February 2007

AbstractTen patients with extremity sarcomas adriamycin 60 mg/M2 into the artery supp supplying the area of tumor. There were minimal local side effects consisting of occasional local erythema or slight transitory pain. Nine of these patients had subsequent surgery, and an average 32.86% histologic tumor necrosis was recorded in the peripherally viable areas of seven patients with residual tumor, compared to a 5.71 % necrosis recorded in the biopsy sections (P value < 0.01).
Mouse colostomy model for studies on large bowel cancer
Authors: Volenec F. J. , McCarthy R. P. , Humphrey M. , Whitmore S. , Humphrey Loren J. 
Published: February 2007

AbstractThe development of appropriate animal model systems has been proposed as a means of facilitating the study of human colorectal cancer. This report describes the development and use of a blind‐colorectal pouch in a carcinoma mouse model.The blind‐pouch was prepared in C57BL/6J mice by surgically exteriorizing the descending colon and producing two stomata in the abdominal wall. The proximal stoma served as an end colostomy and the distal stoma created as a mucous fistula. Surgical closure of the anus thus provided a colorectal pouch.In pilot studies it was found that N‐methyl‐N‐nitrosourea (MNU) and radiation together but neither separately produced tumors in the pouch of surviving mice. Further, inoculation of C38 syngeneic tumor cell suspension into the pouch and immediate closure resulted in tumor takes within three to four weeks. The use of this model in carcinogenesis and the immunology of colon cancer simulate the human colorectal cancer problem more closely than previous animal models.
Significance of 99mTc‐sulfur colloid splenic image in malignant melanoma
Authors: Berjian R. A. , Parthasarathy K. L. , Didolkar M. S. , Bakshi S. P. , Moore R. H. 
Published: February 2007

AbstractTo evaluate the clinical significance of 99mTc‐sulfur‐colloid (TcSC) spleen scan findings in patients with malignant melanoma, a retrospective study was undertaken. Eighty‐one patients with histologically proven malignant melanoma who received treatment in Roswell Park during a five‐year period were included in this study.The scans were analyzed for spleen size, differential uptake of the tracer in liver and spleen, and for the presence of metastases in these two organs. These data were compared with stage of disease, survival, and autopsy findings.Significant correlation was found between the splenic size as measured on the scintiscan and at autopsy examination. The spleen size was found to be normal in 92% of the patients in early melanoma. The median survival of patients who had a normal‐sized spleen by scan criteria was found to be longer than those who had splenomegaly. No significant difference in survival was noted between the patients with and without augmented splenic uptake of TcSC. Only a small number (17.7%) of patients with augmented splenic uptake had splenic metastases; hence, the possible role of immunological factors was considered.
Le Veen shunts in patients with intractable malignant ascites
Authors: Kudsk Kenneth , Fabian Timothy C. , Minton John P. 
Published: February 2007

AbstractLeVeen shunts were placed in ten patients bedridden with intractable malignant ascites in order to improve comfort and ambulation. The procedure was done with local anesthesia and mild sedation in all but one patient. Mild prolongations in clotting studies and hypokalemia were noted in several patients, but severe complications were few: a bleeding diathesis in a jaundiced patient, and venous disease in two. Six of the ten had excellent clinical response and were able to undergo therapy impossible in the presence of massive ascites. Two had moderate benefit but remained bedridden. Two patients gained no relief. Elevated bilirubin and inability to tolerate rapid increase in vascular volume and excrete the fluid load contraindicate the procedure, but the LeVeen shunt appears to be of significant clinical benefit in selected cases of malignant ascites.
Production and characterization of xenogeneic antisera to tumor‐associated antigen(s)
Authors: Gupta Rishab K. , Silver Hulbert K. B. , Morton Donald L. 
Published: February 2007

AbstractTumor‐associated antigen(s) from a specimen of human malignant melanoma and from spent culture medium of a melanoma cell line were extracted and purified. The incidence of antibody activity to these antigens, in sera from cancer patients with neoplasms of various histologic types, was higher (65–83%) than normal donors' (19–25%) by the complement fixation assay. These purified antigens were then used to raise antisera in rabbits and sheep. After absorption with various human normal tissues, these antisera reacted against melanoma, sarcoma, and carcinoma extracts, but not against human normal liver, skin, or muscle extracts. However, the antisera showed reactivity against a human fetal homogenate. Results indicate that the xenogeneic antisera contained antibodies to fetal antigens and to tumor‐associated antigen(s). Xenogeneic antisera could be used to purify tumor‐associated antigens and oncofetal antigen(s) from crude extracts by affinity chromatography.
The potentialities and prospects for surgical methods of diagnosis of cancer of the lung
Authors: Pirogov A. I. , Wagner R. I. , Matytsin A. N. 
Published: February 2007

AbstractSurgical methods of diagnosis make it possible to determine in patients with lung cancer the actual local extension of tumour and its metastatic foci. The diagnostic thoracotomy plays an important role in the complex diagnosis of lung cancer.Diagnostic thoracotomy has been performed in 109 out of 1215 patients with lung cancer and other lung lesions suspicious for cancer. Primary lung cancer, mostly at early stage, was detected in 50 out of 109 patients. Among 308 patients who had been subjected to Daniels operation, metastases were revealed in 130 cases (42.2%); prescalene lymph nodes were found inpalpable in 12.4% and palpable in 64.4% of cases.Mediastinoscopy carried out in 262 patients revealed metastases in 36.2% of cases. Parasternal mediastinotomy allowed definition of the degree of tumor extension in 49.5% of cases. Application of laparoscopy and laparotomy revealed metastases in the organs of the abdominal cavity and retroperitoneal space in 13.5% of patients.Results of studies show a definite relationship between the frequency of metastases development in the lymph nodes and distant organs and tumor site as well as clinico‐anatomical forms and morphological structure of tumor. Application of surgical diagnostic methods should be done according to strict indications.
Metastases to eyelids: Breast
Authors: Lawton Richard L. , Hobbs Beverly , Jochimsen Peter 
Published: February 2007

AbstractEdema and erythema of the right eyelid were the first clinical symptoms of widely metastatic carcinoma in a 61‐year‐old female. At the time of biopsy of the eyelid there were no other clinical manifestations of the disease. The case history points out a rare manifestation and emphasizes the many faces of breast cancer.
Clinical role of the mixed cell agglutination test in the prospective management of superficial bladder tumors
Authors: Johnson J. Daniel , Lamm Donald L. , Radwin Howard M. 
Published: February 2007

AbstractThe mixed cell agglutination test allows the selection of patients with transitional cell carcinoma of the bladder who are at risk to develop invasive disease. A review of our retrospective experience and that of others reveals an overall accuracy of 78% in the prediction of tumor behavior. Current prospective studies are described and a rational, selective approach to the follow‐up of bladder tumor patients, influenced by the MCA test result, is advocated.
Improvement of hepatic dearterialization: A case report
Authors: Idema Albertus A. J. , Tjiong Harry S. L. , Oldhoff Jan 
Published: February 2007

AbstractDearterialization of the liver causes necrosis of primary liver tumors or metastases, because their blood supply is largely arterial. The normal liver tissue remains vital after a period of ischemia if the portal vein is intact.A patient with a carcinoid syndrome due to liver metastases is described.It was found that it is difficult to achieve complete dearterialization of the liver. Rather, preoperative and particularly peroperative angiograms are required to ensure the best possible degree of dearterialization.
Breast cancer metastasis and lymph node lymphocyte‐macrophage interaction
Authors: Richters Arnis 
Published: February 2007

AbstractA lymphocyte‐macrophage interaction, known as the lymphocyte clustering phenomenon, was studied in axillary lymph node preparations from 27 breast cancer patients. The study was carried out in primary tissue cultures of lymph nodes and the lymphocyte‐macrophage interactions were quantitated with respect to cancer positive and cancer negative axilla. The results indicate that there is a significantly higher (p< 0.025) lymphocyte‐macrophage interaction in negative node preparations from negative axilla of infiltrating ductal carcinoma patients. This new approach to lymph node lymphocyte evaluation may provide assistance in determining the extent of the disease process.
Long survival following combined treatment of inoperable cholangiocarcinoma: Surgery, radiotherapy, and chemotherapy
Authors: Hashmonai M. , Lev Louise , Schramek Alfred , Ben‐Arieh Yudith , Robinson Eliezer 
Published: February 2007

AbstractA jaundiced patient due to inoperable bile duct carcinoma was treated by a combination of surgery, radiotherapy, and chemotherapy. At the operation an intra‐abdominal, extracholedochal bypasss of the tumor was performed with a T‐tube and bile drainage into the duodenum achieved. Local radiotherapy and chemotherapy with 5‐fluorouracil were given. A second operation was performed due to T‐tube obstruction 10 months after diagnosis, and no evidence of malignancy was seen. The T‐tube was replaced by an Argyle tube. One year later jaundice reappeared, due to displacement of the tube, and islets of metastatic tumor cells in the hilus of the liver were found. A further bypass relieved the jaundice and additional cytotoxic treatment was given. Three months later, after the patient's demise due to an unrelated cause, no evidence of the disease was found.This case demonstrates the importance of palliative by‐passing of the tumor in order to relieve obstruction, thus enabling further oncological treatment, which may be, as in the present case, highly effective.
Lobular carcinoma in situ
Authors: Powers Robert W. , O'Brien Paul H. , Kreutner Albert 
Published: February 2007

AbstractLobular carcinoma in situ remains controversial in nomenclature, histology, and therapy. The original description and therapeutic recommendations remain a significant contribution to better control of breast cancer. We believe the sophistication of mammography, not available at the time of the earliest therapeutic recommednations, provides the clinician with a valuable and accurate new diagnostic tool for this disease.The risk factors from this disease entity have been well outlined by McDivitt [1] and others. We believe the patient should permitted to participate in the therapeutic decision after proper education about the risk factors of cancer in the ipsilateral and contralateral breast. Patients have requested bilateral mastectomies; some of these patients then wanted plastic reconstruction. Many others, however, have no such interest. The properly informed and responsible patient who elects to have close observation, with mammograms every six months, we feel has elected an acceptable clinical strategy for this disease.