bluuebunny/crossref_metadata_2025_split huggingface dataset:
Short report: Associations of family characteristics and clinicians’ use of caregiver coaching in early intervention
Authors: Hernandez Alyssa M , Straiton Diondra , Mandell David S , Ingersoll Brooke , Crabbe Samantha , Rieth Sarah , Pellecchia Melanie 
Published: February 2025

There is a great demand for quality early intervention services for autistic children and their families. Caregiver-mediated interventions are critical components of evidence-based early intervention. However, their implementation in publicly funded systems is often done with poor fidelity. Qualitative evidence suggests that family characteristics impact clinicians’ use of caregiver-mediated intervention coaching strategies. We estimated associations between family characteristics and clinicians’ use of a caregiver-mediated intervention in a publicly funded early intervention system, leveraging data from a pilot randomized trial. Data were collected from 12 clinicians and 34 families. We used multiple linear regression models to estimate associations. The association between household income and clinicians’ overall coaching fidelity demonstrated a quadratic trend ( b  = −10.4, standard error = 4.1, p < 0.05) with low fidelity for low- and high-income families relative to middle-income families. Use of in vivo feedback, one component of coaching, was similarly associated with income ( b  = −0.5, standard error = 0.2, p < 0.05). Clinicians’ coaching fidelity was lower among families in exclusively English-speaking homes than for families who speak other languages ( b = 18.4, standard error = 8.8, p < 0.05). Results suggest that associations between family characteristics and clinician behavior may be more nuanced than previously understood. Lay abstract There is a high demand for quality early intervention services for autistic children and their families. A key part of effective early intervention is teaching caregivers how to support their child’s development through caregiver-mediated interventions. However, in publicly funded programs, these strategies are often not followed correctly. Some studies suggest that family characteristics may influence how well clinicians apply these coaching methods. In this study, we explored the connection between family factors, like household income and language spoken at home, and the way clinicians coached families. We found that clinicians used coaching strategies less consistently with both lower- and higher-income families compared to middle-income ones. In addition, families that spoke only English at home received less consistent coaching than those who spoke other languages. These findings highlight the complex relationship between family background and how early intervention services are delivered, suggesting a need for further research.
Clinical predictors of unplanned reoperations in trauma patients with damage control surgeries for truncal injuries
Authors: Semanco Michael , Montero Jennifer , Russell Nancy , Diaz Ashley , Gaugler Andrew C. 
Published: February 2025

Purpose The purpose of our study is to identify risk factors associated with unplanned or early reoperations in trauma patients with truncal injuries who received damage control surgeries. Methods This was an Institutional Review Board approved, single center, retrospective cohort evaluation. Trauma patients with truncal injuries who required an index surgery for damage control followed by a reoperation were divided into two groups based on the timing of their reoperation, planned (reoperation within 24–48 h) and unplanned groups (reoperation < 24 h). The primary outcome was to identify risk factors associated with unplanned trips to the operating room following the index surgery. Results Of the 142 trauma patients who underwent a damage control surgery, 42 patients were included for analysis (24 in the planned group and 18 in the unplanned group). The most common causes for unplanned reoperations were hemodynamic instability ( n = 7) and bleeding ( n = 8). Vasopressor administration (OR = 10.5, 95% CI [2.475, 44.54]), shock index > 1.2 (OR = 5.9, 95% CI [1.35, 25.88], and hemoglobin (Hgb) < 10 and/or a hematocrit (Hct) < 29 (OR = 8, 95% CI [1.5, 46.65] and/or OR = 17, 95% CI [1.94, 148.85], respectively) were associated with an increased odds of an unplanned return to the operating room. Conclusion Following damage control surgery, vasopressor administration, elevated shock index, and decreased Hemoglobin/Hematocrit may help identify patients who are at risk of requiring early or unplanned returns to the operating room.
Upper Extremity-Cognitive Dual-Task Capacity Post-Stroke
Authors: Bachar Kirshenboim Yishai , Tzur Lebovich Shir , Weitzer Tal , Doron Dana , Bondi Moshe , Cialic Ron , Rand Debbie 
Published: February 2025

Background Dual-task capacity, which might be impaired poststroke, is needed for daily functions. Therefore, dual-task capacity should be assessed during rehabilitation. The Dual Overload Interference Test (DO-IT) is a new upper extremity (UE) protocol for assessment, combining The Box and Block Test with the Counting Backwards Test. Objectives To validate DO-IT by comparing between (1) young and older healthy, (2) stroke and healthy participants. Additionally, to correlate DO-IT with (3) walking-cognitive dual-task assessment (healthy), and (4) standardized cognitive and EF assessments (stroke). Methods A cross-sectional study included younger and older community-dwelling healthy individuals (N = 32), and younger and older individuals with stroke (N = 83). DO-IT was administered to all participants. The #blocks transferred (motor) and #correct numbers counted (cognitive) were recorded for single and dual conditions. The walking-cognitive dual-task test was administered to the healthy participants. Motor and cognitive costs were calculated as the difference between single and dual tasks. The Montreal Cognitive Assessment test (MoCA) and the Color Trail Test (CTT) assessed cognition post stroke. Results Older healthy adults had significantly lower dual-task motor capacity compared to younger adults (median [interquartile range] blocks: older 26 [21-38], younger 46 [38-52], P < .01). Participants with stroke showed higher motor costs than healthy participants. Dual-task costs correlated between DO-IT to walking-cognitive (motor; r = .37-.41, cognitive; r = .41-.47, P < .05). DO-IT motor cost negatively correlated with MoCA ( r = −.27, P < .05), and DO-IT motor performance correlated with MoCA/CTT-A\B ( r = .29-.60, P < .05). Conclusions UE-Cognitive dual-task capacity is affected post-stroke. DO-IT shows potential for use in stroke rehabilitation and its validity should be further researched.
Venetoclax added to CLAG regimen might improve the outcome of patients with relapsed/refractory acute myeloid leukemia
Authors: Zhang Yu , Yin Zhao , Yao Zurong , Xu Dan , Jiang Xuejie , Nie Xiaqi , Chen Dandan , Zhou Hongsheng , Shi Pengcheng , Liu Hui , Liu Qifa , Yu Guopan 
Published: February 2025

Background: We aim to analyze the efficacy and safety of Venetoclax (Ven) added to cladribine + cytarabine + granulocyte colony-stimulating factor (G-CSF) ± idarubicin or mitoxantrone (CLAG ± Ida/Mito) regimen as a salvage treatment of relapsed/refractory acute myeloid leukemia (RR-AML). Methods: A single-center, retrospective, cohort study was performed. Patients with RR-AML, being treated with CLAG ± Ida/Mito with versus without Ven, were retrospectively studied. The endpoints of this study were to evaluate the rate of composite complete remission (CRc), measurable residual disease (MRD), event-free survival (EFS), overall survival (OS), and relapse between CLAG and CLAG + Ven groups. Results: Sixty-nine patients were included, with a median age of 37 (range, 18–65) years. Thirty-one patients underwent one cycle of salvage treatment of CLAG ± Ida/Mito with Ven and 38 without. In the CLAG + Ven group, 24 (77.4%) patients acquired response, including 22 (71.0%) with composite complete remission (CRc) and 15 (48.4%) MRD-negative CRc, which was significantly higher than those (CRc 47.4%, p = 0.048; MRD-negative CRc 18.4%, p = 0.008) in the CLAG group. Subgroup analysis showed that patients without response after two courses of induction therapy, or patients with FLT3 mutations seemed to benefit more from CLAG ± Ida/Mito + Ven than CLAG ± Ida/Mito in acquiring CRc. With a median follow-up of 13 (95% CI 10.5–15.5) months, the CLAG + Ven group had a median OS of 22.9 (95% CI 19.6–26.2) months and EFS of 15.7 (95% CI 11.1–20.2) months. In contrast, the CLAG group had a median OS of 18.6 (95% CI 14.7–22.6) months and EFS of 10.7 (95% CI 6.6–14.8) months. Although not statistically significant, patients in the CLAG + Ven group showed a potential survival advantage compared to the CLAG group. AEs including all grade and grade 3/4 occurred at similar frequencies in the two groups. Conclusions: Ven added to CLAG ± Ida/Mito might improve the outcome of the patients with RR-AML, with well toleration, and a randomized controlled trial is needed to explored.
Facile synthesis of copper, nickel and their bimetallic nanoparticles: optical and structural characterization
Authors: Aman Abdul Waheed , Krishnan Ganesan , Sadiqi Mohammad Abdullah , Alhajj Mahmood , Hidayat Nurul 
Published: February 2025

Abstract
This paper reports the synthesis and characterization of some spherical crystalline copper (Cu), nickel (Ni), and their bimetallic (Cu–Ni) nanoparticles (NPs) produced in deionized (DI) water via pulse laser ablation in liquid (PLAL) technique. XRD and SAED patterns showed the high crystallinity of the synthesized nanostructures with face-centered cubic structure. The TEM and HRTEM images revealed the nucleation of spherical nanocrystals with a size range of 2.5–25 nm, and no remarkable aggregation was seen. Some core–shell oxidized Cu and Ni nanostructures related to the dissolved oxygen in DI water were detected. The UV–Vis absorption spectra at different aging times showed that pure metal nanoparticles are more stable than bimetallic nanoparticles. Localized surface plasmon resonance (LSPR) absorption peaks were recorded at 645 nm and 596 nm wavelengths for Cu and Cu–Ni colloidal solutions, respectively. The PL emission peaks at shorter wavelengths indicated that synthesized nanoparticles are blue luminescent. The achievement of pure and spherical copper, nickel, and their bimetallic nanoparticles with enhanced optical properties could be beneficial for advancing photocatalysis and antibacterial activity.
Factors influencing quality of professional life and perceived bullying among medical residents in Iran
Authors: Assadpour Nima , Alazmani-noodeh Farshid , Baniyaghoobi Faeze , Shafiei Kisomi Zahra , Bahrami Mahdie , Ghasemnegad Seideh Madineh , Ranjbar Hadi 
Published: February 2025

Abstract

Objectives
During residency training, medical doctors, face significant challenges that can impact their quality of professional life, their performance, and the care they provide. The current study aimed to examine factors affecting the quality of professional life and their perception of bullying.

Design/ participants
This was a cross-sectional study with 231 medical residents.

Setting
Educational hospitals affiliated with Iran University of Medical Sciences in Tehran, Iran.

Methods
Participants completed a questionnaire that included demographic data, the Negative Act Questionnaire-Revised (NAQ-R), and the Professional Quality of Life Scale (ProQol-5). The study included 231 medical residents from medical university-affiliated hospitals.

Results
Bullying had a significant negative effect on the quality of professional life (B = -1.173, p < 0.001), while satisfaction with income positively affected it (B = 2.111, p = 0.016). Gender, marital status, feeling respected, age, shift hours, residency year, and medical-surgical department were not significant predictors. Longer shift hours per week (B = 0.306, p = 0.044) and more experienced residents (B = -1.376, p = 0.010) were associated with higher and lower bullying perceptions, respectively.

Conclusions
The study highlights the significant negative impact of bullying on the quality of professional life among medical residents. Suitable interventions should be considered to reduce this impact. Potential interventions could include implementing comprehensive training programs focused on emotional intelligence and communication skills, establishing clear reporting mechanisms for bullying incidents, and fostering a supportive workplace culture prioritizing respect and collaboration among healthcare professionals.
A novel method for screening malignant hematological diseases by constructing an optimal machine learning model based on blood cell parameters
Authors: Sun Dehua , Chen Wei , He Jun , He Yongjian , Jiang Haoqin , Jiang Hong , Liu Dandan , Li Lu , Liu Min , Mao Zhigang , Qu Chenxue , Qu Linlin , Sun Ziyong , Wang Jianbiao , Wu Wenjing , Wang Xuefeng , Xu Wei , Xing Ying , Zhang Chi , Zhang Jingxian , Zheng Lei , Zhang Shihong , Ye Bo , Guan Ming 
Published: February 2025

Abstract

Background
Screening of malignant hematological diseases is of great importance for their diagnosis and subsequent treatment. This study constructed an optimal screening model for malignant hematological diseases based on routine blood cell parameters.

Methods
The venous blood samples of 1751 patients collected from 10 tertiary hospitals in China were divided into a training set (1223 cases) and a validation set (528 cases). In addition to the clinical diagnostic information of the samples in the training set, 26 blood cell parameters including morphological parameters were selected using manual screening and filtering to construct eight machine learning models. These models were used to identify hematological malignancies among the validation set.

Results
Comparison of the discrimination, calibration and clinical detection performance of the eight machine learning models revealed that the artificial neural network (ANN) model performed the optimal in identifying malignant haematological diseases in the validation set (528 cases), with an area under the receiver operating characteristic curve (AUC), accuracy, sensitivity and specificity of 0.906, 0.857, 0.832 and 0.884, respectively.

Conclusion
The ANN model constructed can be used for screening of malignant hematological diseases, especially in primary hospitals that lack comprehensive diagnosis, and this ANN model will help patients to get diagnosis and treatment of malignant hematological diseases as early as possible.
Unlocking prevention: the role of health literacy in cervical cancer screening: community nursing perspective
Authors: Mohamed Amin Shaimaa , Metwally El-Sayed Mona , Hashem El-Monshed Ahmed , Hussein Ramadan Atta Mohamed 
Published: February 2025

Abstract

Introduction
Cervical cancer presents a significant global public health challenge, particularly affecting low- and middle-income countries like Egypt. Despite the availability of effective screening methods such as Pap smears and HPV testing, the incidence of cervical cancer remains high in Egypt. Health literacy, which refers to the ability to access, understand, and utilize basic health information and services to make informed decisions, is crucial in influencing individuals’ health behaviors, including their participation in cancer screening programs.

Objectives
To examine the correlation between health literacy levels and cervical cancer screening behaviors among women.

Methods
This study employed a multi-site cross-sectional research design from September 2023 to January 2024. The research was conducted at four primary health care (PHC) facilities in the Damanhur district of Egypt. Three hundred fifty women participated in the study, completing a comprehensive questionnaire that included a Woman’s Social and Health Form, a Cervical Cancer Knowledge Scale, a Cervical Cancer Screening Behaviors Scale, and a Health Literacy Scale (HLS-SF12).

Results
The study revealed significant relationships between the importance of health literacy (HL) in understanding cervical cancer (CC) knowledge and screening behaviors among Egyptian women. A positive correlation was found between Knowledge and HL (r = 0.507, p < 0.001). Conversely, perceived barriers negatively correlated with knowledge and HL (r = -0.172, p < 0.05; r = -0.277, p < 0.01). The regression analysis revealed that higher levels of HL were significantly associated with greater knowledge about CC (B = 0.148, p < 0.001). Conversely, knowledge about CC was also found to be a strong predictor of higher HL levels (B = 1.205, p < 0.001). These results highlight the bidirectional relationship between HL and knowledge, where improvements in one can enhance the other.

Conclusion
Addressing misconceptions and increasing knowledge about the importance of regular screenings, mainly through accessible and culturally appropriate channels, could lead to an improved uptake of cervical cancer screening services. Overall, this study lays a foundation for future research to continue exploring ways to improve cervical cancer prevention and control efforts among women.

Clinical trial number
Not applicable.
Decision-making in interhospital transfer of traumatic brain injury patients: exploring the perspectives of surgeons at general hospitals and neurosurgeons at neurotrauma centres
Authors: Cuevas-Østrem Mathias , Wisborg Torben , Røise Olav , Helseth Eirik , Jeppesen Elisabeth 
Published: February 2025

Abstract

Background
Traumatic brain injury (TBI) is a significant public health concern. Advancing age and comorbidities are associated with a reduced probability of being transferred to neurotrauma centres (NTCs) from non-neurosurgical acute care trauma hospitals (ACTHs). However, the extent to which these decisions reflect well-considered treatment-limiting decisions and which influence other factors have on the decision-making process remains unclear.

Objective
To increase the understanding of adults’ access to NTC care by exploring the decision-making process for interhospital transfer of patients with isolated TBI, elucidating factors influencing these decisions.

Methods
Fifteen surgeons and neurosurgeons from four hospitals in Norway were recruited through purposive sampling to four semi-structured focus group interviews. Surgeons represented ACTHs and neurosurgeons NTCs, and all participants were responsible for TBI patients' initial care and transfer decisions. Interviews were thematically analysed.

Results
We identified several factors influencing transfer decisions, captured in six main themes under one overarching theme; ‘The chance of a favourable outcome’. The six main themes reflect surgeons’ and neurosurgeons’ decision-making process, which included clinical and system-level factors: (A) ‘Establish TBI severity: Glasgow Coma Scale score and head CT’, (B) ‘Preinjury health status: comorbidity, functioning, and age’, (C) ‘Distance from ACTH to NTC: distance is time and time is brain’, (D) ‘Uncertainty and insecurity’, (E) ‘Capacity at NTC’, and (F) ‘Next of kin involvement’.

Conclusion
On-call surgeons and neurosurgeons responsible for making transfer decisions for TBI patients emphasise the importance of patient-centred decisions, including individual patients’ risk factors and overall health status.
The patient experience of CHAPLE disease: results from interviews conducted as part of a clinical trial for an ultra-rare condition
Authors: Litcher-Kelly Leighann , Ozen Ahmet , Ollis Sarah , Feldman Hagit Baris , Yaworsky Andrew , Medrano Paolo , Chongsrisawat Voranush , Perlee Lorah , Walker Marisa , Pradeep Sharanya , Turner-Bowker Diane M. , Kurolap Alina , Adiv Orly Eshach , Lenardo Michael J. , Harari Olivier A. , Jalbert Jessica J. 
Published: February 2025

Abstract

Background
CD55 deficiency with hyper-activation of complement, angiopathic thrombosis, and protein-losing enteropathy (CHAPLE) disease is a newly identified condition with an estimated worldwide prevalence of < 100 patients. Patient interviews can ensure that what is important to patients is assessed in a clinical trial program. Due to the rare and potentially fatal nature of CHAPLE disease, interviews were conducted as part of the pozelimab clinical trial, rather than in a separate study before the trial. The aim of the interviews was to identify the key disease-related signs, symptoms, and health-related quality-of-life (HRQoL) impacts that are important and relevant to patients with CHAPLE disease.

Methods
Interviews were conducted with patients and/or caregivers at two timepoints (screening and Week 24) during the pozelimab trial to document the signs/symptoms and HRQoL impacts of CHAPLE disease, and document the most bothersome sign/symptom at screening. At Week 24, interviews gathered additional information on the patient experience from caregivers and patients (note: the impact of pozelimab treatment was also collected, though these results are presented elsewhere).

Results
Ten patients, aged 3–19 years, were enrolled in the trial; caregivers contributed to nine interviews. Thirty-one signs‌/symptoms and 65 HRQoL impacts were reported during the interviews. Abdominal pain, diarrhea, facial and peripheral edema/‌swelling, nausea, and vomiting emerged as the core signs/‌symptoms of CHAPLE disease (i.e., experienced by ≥ 90% of patients prior to treatment). The remaining 25 signs/symptoms were experienced by four or fewer (n ≤ 4, ≤ 40.0%) patients, and 15 were only reported by one patient each. Abdominal pain and facial edema were reported as the most bothersome signs/‌symptoms (n = 9, 90.0% and n = 1, 10.0%, respectively). The most frequently reported (i.e., ≥ 80% of interviews) HRQoL impacts were restricted diet (n = 10, 100.0%), sleep disruptions (n = 10, 100.0%), missing school (n = 9, 90.0%), ability to get dressed independently (n = 8, 80.0%), and difficulty engaging in play activities (n = 8, 80.0%).

Conclusions
The main finding from these patient interviews is the identification of six core signs/symptoms of CHAPLE disease: abdominal pain, diarrhea, facial edema/swelling, peripheral edema/swelling, nausea, and vomiting. The severity of the core signs/symptoms leads to substantial impacts on patients’ lives.

Trial registration
ClinicalTrials.gov, NCT04209634. Registered 20 December 2019 https://classic.clinicaltrials.gov/ct2/show/NCT04209634.
Self-managed abortion as a humanitarian revolution: accounts of a telehealth pilot in the Middle East
Authors: Lasserre Laureline , Staderini Nelly , Hasan Maysa’a , Rossi Vanessa 
Published: February 2025

Abstract

Background
Access to safe abortion care (SAC) should be improved in fragile and humanitarian settings, and the implementation of interventions in that regard are currently limited. This is especially true for self-managed abortion (SMA), although it holds the potential of revolutionizing the prevention of maternal death and suffering.

Case presentation
The medical humanitarian organization Doctors Without Borders/Médecins Sans Frontières (MSF) piloted a self-managed abortion model of care in the Middle East. 22 women were remotely supported in managing their safe abortions with a counsellor over the phone, using misoprostol doses that they took at home after having taken mifepristone in our health facility. We share our experience by describing the model of care and discussing the lessons learned through its implementation.

Conclusions
The program delivered abortion services successfully and required few resources. This paper also reflects on the importance of facilitating SMA in humanitarian contexts. It increases access to care by providing increased confidentiality, close support, ample information, autonomy, and flexibility. It is simple to implement, effective, often preferred by women, and can be linked to information about contraception. The implementation of self-managed models should be expanded, notably in projects that do not have a sexual and reproductive health focus and in restrictive and challenging contexts. It represents a true revolution for access to safe abortion care.