bluuebunny/crossref_metadata_2025_split huggingface dataset:
Heimler syndrome with a complaint of blurred vision caused by compound heterozygous variants in PEX1
Authors: Zhang Yanchen , Li Zhixing , Lin Bing , Liu Xiaoling , Sun Zuhua 
Published: March 2024

Introduction Heimler syndrome (HS) is a rare disorder that includes sensorineural hearing loss (SNHL), nail abnormalities, and enamel hypoplasia. Patients with this syndrome can also exhibit ocular manifestations. At present, only a few cases of HS have been reported, existing knowledge of this syndrome is limited, and many cases have been misdiagnosed or even missed. This is the first report of Heimler syndrome with blurred vision as the first complaint, which was diagnosed by genetic analysis in the ophthalmology department. Case description An 8-year-old girl complained of bilateral visual blur and night blindness from birth. Ophthalmic examinations revealed bilateral retinitis pigmentosa with cystoid macular edema, visual impairment with hyperopia and astigmatism. Hearing test revealed bilateral severe sensorineural hearing loss. Dental examinations revealed enamel hypoplasia. In addition, whole-exome sequencing (WES) identified two pathogenic variants in PEX1: the previously reported missense variant c.2966T > C (p.I989 T), and the novel frameshift variant c.1671_1672del (p.G558Sfs*33). Conclusion Heimler syndrome is caused by compound heterozygous PEX1 pathogenic variants, c.2966T > C (p.I989 T) and c.1671_1672del (p.G558Sfs*33), which contributed to the diversity of clinical and genetic profiles in this patient. The main clinical manifestations include bilateral retinitis pigmentosa with cystoid macular edema, sensorineural hearing loss, and enamel hypoplasia. Systemic examinations are suggested for patients suspected of having pigmentary retinal dystrophy, especially combined with hearing-related impairments. Genetic testing can help us to make a definitive diagnosis.
Extricating the concept of linking value from its tribal gangue
Authors: Cova Bernard , Barès Franck 
Published: March 2024

The concept of linking value appeared in the marketing literature 30 years ago, at the height of the postmodern wave. In this text, we show that to reinvigorate this concept, it is necessary to break with its tribal roots. The tribal anchoring, which was the strength of its initial theorization because it attracted researchers, is now a drawback because it limits the potential applications of the concept of linking value at a time when the social world is undergoing fundamental change. Our aim is to reopen the black box of linking value that marketing researchers have kept closed during the last few decades.
Biomechanical analysis of tendon turnover tenorrhaphy compared to direct repair and Pulvertaft weave
Authors: Barabas Anthony , Patel Manal I. A. , Sutcliffe Michael 
Published: March 2024

The aim of the present study was to evaluate biomechanical properties of tendon turnover repair in comparison to direct repair and Pulvertaft weave. A total of 48 sheep flexor tendons were assigned to eight groups comprising single or double tendon turnover repair, tendon turnover segment (without tenorrhaphy), direct repair or Pulvertaft weave. Tensile strength, stiffness and failure mechanisms were evaluated with a 500 N load cell. Turnover repair showed no significant difference in tensile strength to direct repair. Failure in turnover repair occurred largely at the site of tenorrhaphy due to suture pull-through or suture rupture. the increase in cross-sectional area after turnover repair was similar to that after direct repair, but less than after Pulvertaft weave. Tendon turnover offers tensile strength similar to direct repair with no associated increase in bulk. It provides a biomechanically secure and quicker alternative to tendon grafting for reconstructing tendon defects, without secondary donor site morbidity. Level of evidence: V
COVID-19 era- digital eye strain and the use of digital devices in online learning: A cross-sectional study of nursing students
Authors: Mrayyan Majd T , Al-Shaikh Ali Marwan H , Al-Reyati Reem , Abed Al-Rahman Myasar , Mrayan Manar 
Published: March 2024

Digital Eye Strain (DES) is a newly recognized healthcare problem. Therefore, this study assessed the frequency, intensity, and prevalence of DES, the usage of digital devices for online learning among nursing students enrolled in nursing courses in a governmental and a private university during the COVID-19 pandemic, compared the usage of digital devices before and after the pandemic, assessed its predictors, and interventions nursing students used to prevent or accommodate DES. A cross-sectional online survey was carried out. Between November and December 2022, data were collected with a purposive sample of 142 nursing students enrolled in nursing courses at a governmental and a private university in Jordan, with a response rate of 88.75%. Our sample didn’t have DES, but when it occurred, it was intense. The most frequent and intense symptoms were reported. The median of the mean score DES indicated that the prevalence of DES was 55.23% (occurred occasionally), and the prevalence of (severe) intensity was 52.11%. The mean daily hours spent using digital devices before and after the pandemic were 3.51 ± 1.96 and 4.51 ± 2.53, respectively; the majority spent 3–4 h. Besides using electronic devices for online learning, our nursing students spent 3.31 ± 1.87 on other activities. Before the pandemic, nursing students commonly used mobile phones. This usage decreased during the pandemic as they moved to computer desktops, laptops, and tablets. Being senior students and using equipment to help protect the eyes predicted the DES. Students used different interventions to prevent or accommodate DES. Based on the international trend, we can conclude that the DES increased during the pandemic; nursing students have spent more hours on digital devices, and over 55.00% have DES. They have frequent serious symptoms from DES, which should be managed immediately. To decrease the prevalence of DES, redesigning our educational system should be prioritized, considering that online learning along with DES will remain even after this pandemic end.
Machine learning methods to discriminate posttraumatic stress disorder: A protocol of systematic review and meta-analysis
Authors: Wang Jing , Ouyang Hui , Jiao Runda , Zhang Haiyan , Cheng Suhui , Shang Zhilei , Jia Yanpu , Yan Wenjie , Wu Lili , Liu Weizhi 
Published: March 2024

Introduction Recent years have witnessed a persistent threat to public mental health, especially during and after the COVID-19 pandemic. Posttraumatic stress disorder (PTSD) has emerged as a pivotal concern amidst this backdrop. Concurrently, machine learning (ML) techniques have progressively applied in the realm of mental health. Therefore, our present undertaking seeks to provide a comprehensive assessment of studies employing ML methods that use diverse data modalities on the classification of people with PTSD. Methods and analysis In pursuit of pertinent studies, we will search both English and Chinese databases from January 2000 to May 2022. Two researchers will independently conduct screening, extract data and assess study quality. We intend to employ the assessment framework introduced by Luis Francisco Ramos-Lima in 2020 for quality evaluation. Rate, standard error and 95% CIs will be utilized for effect size measurement. A Cochran's Q test will be applied to assess heterogeneity. Subgroup and sensitivity analysis will further elucidate the source of heterogeneity and funnel plots and Egger's test will detect publication bias. Ethics and dissemination This systematic review and meta-analysis does not encompass patient interactions or engagements with healthcare providers. The outcomes of this research will be disseminated through scholarly channels, including presentations at scientific conferences and publications in peer-reviewed journals. PROSPERO registration number CRD42023342042.
A Cross-Cultural Exploration of Student Development in Higher Education: Acknowledging, Exercising, and Enhancing Agency
Authors: Yang (杨力苈) Lili , Lee (이소영) Soyoung , Oldac Yusuf Ikbal 
Published: March 2024

Purpose Students develop and grow throughout higher education. However, the underlying mechanism remains unclear. Building on the premise that individuals develop and grow through interacting with the world, this study explores how students develop, grow, and become empowered in higher education through the lens of I–world interactions. Design/Approach/Methods This study employs a multicultural and multidisciplinary approach by first examining different cultural philosophical approaches to I–world interactions. This is followed by an elaboration of what the interactions mean for individual development and growth in higher education by drawing on psychology, sociology, and educational research. Findings This study argues that there are three essential elements of I–world interactions across three philosophical approaches: acknowledged, exercised, and enhanced individual agency. In higher education, students are strong agents, as demonstrated by sociological theories of agency and psychological evidence of agentic human functioning. Students actively exercise their agency, particularly when interacting with the environment. If organized and practiced well, universities can help students enhance their agency. Originality/Value The three shared elements and empirical evidence together form the foundation for understanding how students become empowered in higher education and for positioning the enhancement of students’ agency at the center of higher education across contexts.
The Effects of Neighborhood Trust and Support on Parenting Stress of Mothers With Young Children in Japan
Authors: Kaneko Noriko , Nishijo Muneko , Agawa Keiko , Ishigaki Kazuko , Nishino Yoshikazu 
Published: March 2024

Introduction: While childrearing can enhance mothers’ psychological well-being, parenting can also increase mental stress for mothers with young children, which is considered a risk factor for child maltreatment. A lack of social capital reportedly influences mothers’ parenting, but few studies have investigated the effects of social capital on the perception of mental stress and well-being associated with childrearing among mothers with young children. Therefore, we investigated the effects of lower perceived neighborhood trust and support on higher mental stress and/or lower well-being associated with childrearing among Japanese mothers with children aged 2 to 3 years. Methods: A total of 570 mothers with children (aged 2-3 years) in nursery school were invited to join the survey. The childrearing perspective scale for mothers (CPS-M97) was used to evaluate mothers’ perceptions of mental stress and well-being associated with childrearing. Odds ratios (ORs) reflecting lower satisfaction/fulfillment scores (ie, well-being) and/or higher burdened/anxious scores (ie, mental stress) associated with perceived social capital levels were analyzed, after adjusting for confounding factors. Results: The OR for lower satisfaction/fulfillment scores was significantly higher (OR = 1.77) for mothers with lower neighborhood trust. Significantly increased ORs for higher burdened/anxious scores were found in mothers with lower neighborhood trust (OR = 1.50) and support (OR = 1.49). The ORs for poor mental status, with lower satisfaction/fulfillment scores and higher burdened/anxious scores, were significantly increased in mothers with lower neighborhood trust (OR = 1.96) and lower neighborhood support (OR = 2.10). Conclusions: Higher social capital was associated with higher psychological well-being and/or lower mental stress in Japanese childrearing mothers. These results suggest that enhancing social capital is necessary to facilitate successful parenting that contributes to the prevention of child maltreatment.
Nailfold Capillaroscopy Findings in Patients With Psoriasis Vulgaris and Different Domains of Psoriatic Arthritis
Authors: Elmesiry Amal M. , Mahmoud Sobhia A. , Mohamed Maha S. , Aly Hany , Elmotaleb Yasser A. , Ghit Mohamad M. , Ibrahim Amira Shahin , Elazab Seham A. , Mokhtar Mona , Rageh Eman A. , Moussa Mai A. , Ismail Sherif , El Zokm Saad M. , Hamoud Hesham 
Published: March 2024

Background Psoriasis is a chronic autoimmune disease with longtime activity and multisystem affection. Nailfold capillaroscopy (NC) is a simple noninvasive microscopic tool useful for identification of nailfold microvasculopathy. Objective The present study aimed to compare NC findings in patients with psoriasis vulgaris (PsV) and psoriatic arthritis (PsA) with different clinical domains. Methods The present cross-sectional study included 200 psoriasis patients classified into five 40-patient groups: group I (GI) included PsA patients with predominant peripheral arthritis; group II (GII) included PsA patients with predominant peripheral arthritis and dactylitis and/or enthesitis; group III (GIII) included PsA patients with predominant axial affection; group IV (GIV) patients included PsA patients with predominant axial affection and dactylitis and/or enthesitis and group V (GV) included patients with PsV. In addition, there were 40 age and sex-matched healthy controls (GVI). Results The studied patients had capillary density of 6.7 ± 3.5/mm with 90 patients (45.0 %) having reduced capillary density. GI-GIV patients had significantly lower capillary density and higher frequency of patients with reduced capillary density as compared to GV patients. The reported capillary dimension in the studied patients is 15.7 ± 7.9 μm and 55 patients (27.5 %) had large/giant capillaries. Patients in GV had significantly lower capillary dimension in comparison to GI-GIV patients. There were 64 patients (32.0 %) with abnormal capillary morphology and 47 patients (23.5 %) with capillary hemorrhages. Conclusions PsA patients of all domains have lower capillary density and larger capillary dimensions as compared to PsV patients.
Characteristics of the oral and gastric microbiome in patients with early-stage intramucosal esophageal squamous cell carcinoma
Authors: Chen Han , Jiang Xingzhou , Zhu Fengyi , Yang Ruoyun , Yu Xin , Zhou Xiaoying , Tang Nana 
Published: March 2024

Abstract
Background
Oral microbiome dysbacteriosis has been reported to be associated with the pathogenesis of advanced esophageal cancer. However, few studies investigated the potential role of oral and gastric microbiota in early-stage intramucosal esophageal squamous carcinoma (EIESC).

Method
A total of 104 samples were collected from 31 patients with EIESC and 21 healthy controls. The compositions of oral and gastric microbiota were analyzed using 16 S rRNA V3-V4 amplicon sequencing. Linear discriminant analysis effect size (LEfSe) analysis was performed to assess taxonomic differences between groups. The correlation between oral microbiota and clinicopathological factors was evaluated using Spearman correlation analysis. Additionally, co-occurrence networks were established and random forest models were utilized to identify significant microbial biomarkers for distinguishing between the EIESC and control groups.

Results
A total of 292 oral genera and 223 species were identified in both EIESC and healthy controls. Six oral genera were remarkably enriched in EIESC groups, including the genera Porphyromonas, Shigella, Subdoligranulum, Leptotrichia, Paludibacter, and Odoribacter. LEfSe analysis identified genera Porphyromonas and Leptotrichia with LDA scores > 3. In the random forest model, Porphyromonas endodontalis ranked the top microbial biomarker to differentiate EIESC from controls. The elimination rate of Porphyromonas endodontalis from the oral cavity to the stomach was also dramatically decreased in the EIESC group than controls. In the microbial co-occurrence network, Porphyromonas endodontalis was positively correlated with Prevotella tannerae and Prevotella intermedia and was negatively correlated with Veillonella dispar.

Conclusion
Our study potentially indicates that the dysbacteriosis of both the oral and gastric microbiome was associated with EIESC. Larger scale studies and experimental animal models are urgently needed to confirm the possible role of microbial dysbacteriosis in the pathogenesis of EIESC. (Chinese Clinical Trial Registry Center, ChiCTR2200063464, Registered 07 September 2022, https://www.chictr.org.cn/showproj.html?proj=178563)
Cyanobacterial elicitor enhances the biomass of Mentha piperita L. and improves the production of high-value rosmarinic acid under in vitro culture of apical meristem
Authors: Shariatmadari Zeinab , Zarezadeh Somayeh , Riahi Hossein , Ghotbi-Ravandi Ali Akbar , Seyed Hashtroudi Mehri , Shahroudi Ensiyeh 
Published: March 2024

Abstract
Background
Rosmarinic acid (RA), like other phenolic compounds, is sources of antioxidants and anti-inflammatory agents in medicinal plants. In vitro culture of plants can improve the medicinal plants’ metabolite profile and phenolic compound quantity. To date, various methods have been proposed to increase this medicinal metabolite in plants, among which the use of bioelicitors can be mentioned. In the present study, a native isolate of heterocystous cyanobacteria, Nostoc spongiaeforme var. tenue ISB65, was used to stimulate the production of biomass and content of RA in Mentha piperita L. (peppermint) grown in vitro from apical meristem. Mentha piperita L. explants were inoculated in half strength Murashige and Skoog (1/2 MS) medium containing cyanobacterial lysate (CL). After 50 days of culturing, the growth indices, the content of photosynthetic pigments, and RA in control and treated plants were measured.

Results
CL inoculation resulted in a significant enhancement in the vegetative growth indices of peppermint, including root and shoot length, plant biomass and leaf number. The content of photosynthetic pigments also increased in cyanobacteria-treated plants. Inoculation with CL increased the RA content by 2.3-fold, meaning that the plants treated with CL had the highest RA content (7.68 mg. g− 1 dry weight) compared to the control (3.42 mg. g− 1 dry weight). Additionally, HPLC analysis revealed the presence of several auxins in CL.

Conclusions
The presence of auxins and the chemical content of CL such as K+ and Ca2+, as regulators of metabolic pathways and molecular activities of cells, may be responsible for the enhanced growth and phenolic compounds of plants under tissue culture conditions. An improvement in RA content in the tissue culture of medicinal plants treated with CL was reported for the first time in this investigation.
Using new indices to predict metabolism dysfunction-associated fatty liver disease (MAFLD): analysis of the national health and nutrition examination survey database
Authors: Li Xu Ming , Liu Song Lian , He Ya Jun , Shu Jian Chang 
Published: March 2024

Abstract
Background
Metabolism dysfunction-associated fatty liver disease (MAFLD), is the most common chronic liver disease. Few MAFLD predictions are simple and accurate. We examined the predictive performance of the albumin-to-glutamyl transpeptidase ratio (AGTR), plasma atherogenicity index (AIP), and serum uric acid to high-density lipoprotein cholesterol ratio (UHR) for MAFLD to design practical, inexpensive, and reliable models.

Methods
The National Health and Nutrition Examination Survey (NHANES) 2007–2016 cycle dataset, which contained 12,654 participants, was filtered and randomly separated into internal validation and training sets. This study examined the relationships of the AGTR and AIP with MAFLD using binary multifactor logistic regression. We then created a MAFLD predictive model using the training dataset and validated the predictive model performance with the 2017–2018 NHANES and internal datasets.

Results
In the total population, the predictive ability (AUC) of the AIP, AGTR, UHR, and the combination of all three for MAFLD showed in the following order: 0.749, 0.773, 0.728 and 0.824. Further subgroup analysis showed that the AGTR (AUC1 = 0.796; AUC2 = 0.690) and the combination of the three measures (AUC1 = 0.863; AUC2 = 0.766) better predicted MAFLD in nondiabetic patients. Joint prediction outperformed the individual measures in predicting MAFLD in the subgroups. Additionally, the model better predicted female MAFLD. Adding waist circumference and or BMI to this model improves predictive performance.

Conclusion
Our study showed that the AGTR, AIP, and UHR had strong MAFLD predictive value, and their combination can increase MAFLD predictive performance. They also performed better in females.
Comparison of vonoprazan and proton pump inhibitors for the treatment of gastric endoscopic submucosal dissection-induced ulcer: an updated systematic review and meta-analysis
Authors: Chen Lizhen , Jiang Dalei , Hu Doudou , Cui Xianghua 
Published: March 2024

Abstract
Background
Both vonoprazan and proton pump inhibitors (PPIs) are currently used to treat artificial ulcers after gastric endoscopic submucosal dissection. However, evidence-based medicine proving the efficacy of vonoprazan is still lacking. Therefore, this meta-analysis aimed to compare the efficacy of vonoprazan and PPIs for the treatment of artificial ulcers after gastric endoscopic submucosal dissection.

Methods
The PubMed, EMBASE and Cochrane Library databases were searched up to September 2023 for related randomized controlled trials (RCTs). RCTs that compared the efficacy of vonoprazan and PPIs in treating artificial gastric ulcers after gastric endoscopic submucosal dissection were included. Two independent reviewers screened the included studies, extracted the data and assessed the risk of bias. The following outcomes were extracted for comparison: ulcer healing rate, ulcer shrinkage rate, delayed postoperative bleeding rate, and ulcer perforation rate.

Results
Nine randomized controlled trials involving 926 patients were included. The pooled results showed that vonoprazan had a significantly lower rate of delayed postoperative bleeding than did PPIs (RR = 0.46; 95% CI = 0.23–0.91; P = 0.03). No significant differences were found in terms of ulcer healing, shrinkage rates, or ulcer perforation rates between vonoprazan and PPIs.

Conclusions
Compared with PPIs, vonoprazan is superior at reducing delayed postoperative bleeding after endoscopic submucosal dissection. However, further studies are needed to prove the efficacy of vonoprazan.

Systematic Review Registration
Identifier CRD42024509227.