bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systematic analysis of cuproptosis abnormalities and functional significance in cancer
Authors: Rumin Shang , Han Xiangming , Zeng Cui , Lv Fei , Fang Rong , Gong Rongrong , Tian Xiaochang , Ding Xiangwu 
Published: April 2024

Background
Cuproptosis is a recently discovered type of cell death, but the role and behavior of cuproptosis-related genes (CuRGs) in cancers remain unclear. This paper aims to address these issues by analyzing the multi-omics characteristics of cancer-related genes (CuRGs) across various types of cancer.

Method
To investigate the impact of somatic copy number alterations (SCNA) and DNA methylation on CRG expression, we will analyze the correlation between these factors. We developed a cuproptosis index (CPI) model to measure the level of cuproptosis and investigate its functional roles. Using this model, we assessed the clinical prognosis of colorectal cancer patients and analyzed genetic changes and immune infiltration features in different CPI levels.

Results
The study’s findings indicate that the majority of cancer-related genes (CuRGs) were suppressed in tumors and had a positive correlation with somatic copy number alterations (SCNA), while having a negative correlation with DNA methylation. This suggests that both SCNA and DNA methylation have an impact on the expression of CuRGs. The CPI model is a reliable predictor of survival outcomes in patients with colorectal cancer and can serve as an independent prognostic factor. Patients with a higher CPI have a worse prognosis. We conducted a deeper analysis of the genetic alterations and immune infiltration patterns in both CPI positive and negative groups. Our findings revealed significant differences, indicating that CuRGs may play a crucial role in tumor immunity mechanisms. Additionally, we have noticed a positive correlation between CuRGs and various crucial pathways that are linked to the occurrence, progression, and metastasis of tumors.

Conclusions
Overall, our study systematically analyzes cuproptosis and its regulatory genes, emphasizing the potential of using cuproptosis as a basis for cancer therapy.
Multiple concentrating solutions for a fractional (p, q)-Choquard equation
Authors: Ambrosio Vincenzo 
Published: April 2024

Abstract
We focus on the following fractional (p, q)-Choquard problem:

(

−
Δ

)

p

s

u
+

(

−
Δ

)

q

s

u
+
V

(

ε
x

)

(

|
u

|

p
−
2

u
+
|
u

|

q
−
2

u

)

=

1

|
x

|

μ

*
F

(

u

)

f

(

u

)

in

R

N

,

u
∈

W

s
,
p

(

R

N

)

∩

W

s
,
q

(

R

N

)

,

u
>
0
in

R

N

,

$\begin{cases}{\left(-{\Delta}\right)}_{p}^{s}u+{\left(-{\Delta}\right)}_{q}^{s}u+V\left(\varepsilon x\right)\left(\vert u{\vert }^{p-2}u+\vert u{\vert }^{q-2}u\right)=\left(\frac{1}{\vert x{\vert }^{\mu }}{\ast}F\left(u\right)\right)f\left(u\right) \,\text{in}\,{\mathbb{R}}^{N},\quad \hfill \\ u\in {W}^{s,p}\left({\mathbb{R}}^{N}\right)\cap {W}^{s,q}\left({\mathbb{R}}^{N}\right), u{ >}0\,\text{in}\,{\mathbb{R}}^{N},\quad \hfill \end{cases}$

where ɛ > 0 is a small parameter, 0 < s < 1,

1
<
p
<
q
<

N

s

$1{< }p{< }q{< }\frac{N}{s}$

, 0 < μ < sp,

(

−
Δ

)

r

s

${\left(-{\Delta}\right)}_{r}^{s}$

, with r ∈ {p, q}, is the fractional r-Laplacian operator,

V
:

R

N

→
R

$V:{\mathbb{R}}^{N}\to \mathbb{R}$

is a positive continuous potential satisfying a local condition,

f
:
R
→
R

$f:\mathbb{R}\to \mathbb{R}$

is a continuous nonlinearity with subcritical growth at infinity and

F

(

t

)

=

∫

0

t

f

(

τ

)

d
τ

$F\left(t\right)={\int }_{0}^{t}f\left(\tau \right) \mathrm{d}\tau $

. Applying suitable variational and topological methods, we relate the number of solutions with the topology of the set where the potential V attains its minimum value.
Incentive-Induced Social Tie and Subsequent Altruism and Cooperation
Authors: Gioia Francesca 
Published: April 2024

Abstract
In this paper, we studied the spillover effects of cooperative and competitive incentive schemes on subsequent decisions involving altruism and cooperation. We collected data with a laboratory experiment where subjects were asked to perform Mini Dictator games and a Public Good game after playing an incentivized real effort task. We found that cooperative incentives foster higher subsequent altruism and cooperation as compared with competitive or individual incentives. By contrast, competitive incentives induced more envy towards competitor peers and more spiteful behaviour when giving implies a larger payoff for the recipient. The effect of incentives on altruism and cooperation was moderated by relative rank in the incentivized effort task and by individual level of impulsivity.
Smartphone swabs as an emerging tool for toxicology testing: a proof-of-concept study in a nightclub
Authors: Willeman Théo , Grunwald Justine , Manceau Marc , Lapierre Frédéric , Krebs-Drouot Lila , Boudin Coralie , Scolan Virginie , Eysseric-Guerin Hélène , Stanke-Labesque Françoise , Revol Bruno 
Published: April 2024

Abstract

Objectives
Smartphones have become everyday objects on which the accumulation of fingerprints is significant. In addition, a large proportion of the population regularly uses a smartphone, especially younger people. The objective of this study was to evaluate smartphones as a new matrix for toxico-epidemiology.

Methods
This study was conducted during two separate events (techno and trance) at an electronic music nightclub in Grenoble, France. Data on reported drug use and whether drugs were snorted directly from the surface of the smartphone were collected using an anonymous questionnaire completed voluntarily by drug users. Then, a dry swab was rubbed for 20 s on all sides of the smartphone. The extract was analyzed by liquid chromatography coupled to tandem mass spectrometry on a Xevo TQ-XS system (Waters).

Results
In total, 122 swabs from 122 drug users were collected. The three main drugs identified were MDMA (n=83), cocaine (n=59), and THC (n=51). Based on declarative data, sensitivity ranged from 73 to 97.2 % and specificity from 71.8 to 88.1 % for MDMA, cocaine, and THC. Other substances were identified such as cocaine adulterants, ketamine, amphetamine, LSD, methamphetamine, CBD, DMT, heroin, mescaline, and several NPS. Numerous medications were also identified, such as antidepressants, anxiolytics, hypnotics, and painkillers. Different use patterns were identified between the two events.

Conclusions
This proof-of-concept study on 122 subjects shows that smartphone swab analysis could provide a useful and complementary tool for drug testing, especially for harm-reduction programs and toxico-epidemiolgy studies, with acceptable test performance, despite declarative data.
Metformin inhibits knee osteoarthritis induced by type 2 diabetes mellitus in rats: S100A8/9 and S100A12 as players and therapeutic targets
Authors: Wang Xin , Qiao Yu , Yuan Fahu , Liu Yi , Hu Jun , Zhang Qingfu , Wang Fuyan , Zhao Zhigang 
Published: April 2024

Abstract
Type 2 diabetes mellitus (T2DM) is a significant risk factor for osteoarthritis (OA), and metformin, as the main therapeutic drug for T2DM, has shown positive effects on OA without a clear mechanism. This study aimed to explore the protective effects and mechanisms of oral metformin in T2DM-induced OA. We identified differentially expressed genes, using the GSE117999 and GSE98918 datasets, and protein–protein interaction networks were analyzed using the MCODE algorithm in cytospace to finalize the OA hub genes (S100A8, S100A9, and S100A12). To validate whether S100A8, S100A9, and S100A12 are potential targets of action for OA, we randomly divided 40 SD rats into a control group (CG, n = 10) and a T2DM group (n = 30). We modeled rats in the T2DM group with streptozotocin (35 mg/kg, i.p.) and a high carbohydrate and fat diet. Finally, 20 were randomly selected and divided into the T2DM group (n = 10) and the treated group (Met + T2DM, n = 10), and the treated group was given Met (180 mg/kg/day) by gavage for 8 weeks. We subsequently used histological assessment to show that oral metformin mitigated the development of T2DM-associated OA as indicated by the OA Research Society International score and articular cartilage thickness, and immunohistochemistry also confirmed that metformin significantly reduced the expression of S100A8, S100A9, and S100A12 in the knee joints of OA rats. In conclusion, metformin demonstrated a protective effect against OA in T2DM-induced rats, slowing knee OA progression by inhibiting S100A8, S100A9, and S100A12 expression. These findings suggest potential biological targets for future OA treatments.
Microwave-assisted ultrafine silver nanoparticle synthesis using Mitragyna speciosa for antimalarial applications
Authors: Darakai Vanessa , Punsawad Chuchard , Jitonnom Jitrayut , Nisoa Mudtorlep , Rattanakit Parawee 
Published: April 2024

Abstract
This study investigates the antiplasmodial activity of ultrafine silver nanoparticles (AgNPs, 2–5 nm) synthesized using a green approach involving the Mitragyna speciosa extract and emphasizing the microwave-assisted irradiation technique. Various synthesis parameters were optimized, resulting in the successful production of spherical AgNPs, which exhibited a characteristic surface plasmon resonance peak at around 440 nm. The synthesized AgNPs demonstrated high stability, indicated by a zeta potential value of −28 mV. The antimalarial efficacy of the microwave-assisted AgNPs against the P. falciparum strain was evaluated, demonstrating a half-maximum inhibitory concentration (IC50) value of 1.56 µg·mL−1. Further enhancement in the antimalarial performance was observed when the AgNPs were conjugated with chloroquine (CQ), a traditional antimalarial drug, achieving an impressive IC50 value of 24 ng·mL−1. Additionally, all formulations exhibited low toxicity, with a cytotoxic concentration (CC50) exceeding 800 µg·mL−1 in Vero cells. Complementing these experimental findings, specific computational studies offered insights into the interactions between silver atoms and bioactive compounds in M. speciosa, as well as shedding light on the dynamics of CQ functionalization. These experimental and computational findings emphasize the potential of a sustainable, low-toxicity, and cost-effective AgNP synthesis process, showcasing significant promise in advancing green nanotechnology for the development of effective antimalarial medications.
Facile synthesis of Ag2ZrO3 nanocrystals with highly enhanced visible-light photocatalytic activity
Authors: Fabbro Maria Tereza , Santos Luís P. S. , Yamamoto Felipe M. , Matsushima Jorge T. , Baldan Maurício R. 
Published: April 2024

Abstract
This paper describes the synthesis of Ag2ZrO3 nanocrystals using coprecipitation and microwave-assisted hydrothermal methods. These nanocrystals were characterized by means of X-ray diffraction, micro-Raman spectroscopy, Fourier transform infrared absorption spectroscopy, field emission scanning electron microscopy, and UV–Visible spectroscopy, and their photocatalytic performance for methylene blue degradation under visible-light irradiation has been tested. The X-ray diffraction, micro-Raman spectroscopy, Fourier transform infrared absorption spectroscopy analyses indicate that the Ag2ZrO3 nanocrystals have good crystallinity and no secondary phases. The UV–Visible spectroscopy results showed a variation in the optical band gap values (2.71–2.97 eV) with increasing temperature, which indicates the possible presence of defects in the crystal lattice at a medium range. Field emission scanning electron microscopy images revealed that the nanocrystals have uneven spherical shapes and average particle size around 50–70 nm. The good photocatalytic efficiency can be attributed to defects in the silver zirconate structure capable of forming the active adsorption sites. Finally, we discuss a photocatalytic mechanism to understand the photocatalytic process in cationic dye (methylene blue) degradation in aqueous solution.
Spatial roles in hockey special teams
Authors: Arsenault Jonathan , Cunniff Margaret , Tulsky Eric , Forbes James Richard 
Published: April 2024

Abstract
Special teams (i.e. power play and penalty kill) situations play an outsized role in determining the outcome of ice hockey games. Yet, quantitative methods for characterizing special teams tactics are limited. This work focuses on team structure and player deployment during in-zone special teams possessions. Leveraging player and puck tracking data from the National Hockey League (NHL), a framework is developed for describing player positioning during 5-on-4 power play and 4-on-5 penalty kill possessions. More specifically, player roles are defined directly from the player tracking data using non-negative matrix factorization, and every player is allocated a unique role at every frame of tracking data by solving a linear assignment problem. Team formations naturally arise through the combination of roles occupied in a frame. Roles that vary on a per-frame basis allow for a fine-grained analysis of team structure. This property of the roles-based representation is used to group together similar power play possessions using latent Dirichlet allocation, a topic modelling technique. The concept of assignments, which remain constant over an entire possession, is also introduced. Assignments provide a more stable measure of player positioning, which may be preferable when assessing deployment over longer periods of time.
Career path clustering of elite soccer players among European Big-5 nations utilizing Dynamic Time Warping
Authors: Wolf Viktor , Lanwehr Ralf , Bieschke Marcel , Leyhr Daniel 
Published: April 2024

Abstract
Prior clustering approaches of soccer players have employed a variety of methods based on various data categories, but none of them have focused on clustering by career paths characterized through a time series analysis of yearly performance quality. Therefore, this study aims to propose a methodology how a career path can be represented as a time series of a player’s seasonal qualities and then be clustered with players that have a similar career path. The underlying data focuses on soccer players from the five largest European soccer nations (Big-5). This allows for the identification of different types of career paths of players and the investigation of significant disparities between career paths among the Big-5 nations. In line with our proposed methodological approach, we identified and interpreted 13 different clusters of player career paths. These range from the cluster with the highest player quality scores to the pattern comprising players with the weakest scores. Further, the detected clusters show significant differences regarding variables of soccer players’ early career phase in adolescence (e.g., age of debut in professional soccer, years spent in a youth academy). The presented approach might represent a first step for stakeholders in soccer to get an objective insight in players’ career by utilizing mainly freely available data sources.
Crystal structure of 4-amino-3,5-dibromobenzonitrile, C7H4Br2N2
Authors: Jiang Jinke , Jiang Hui 
Published: April 2024

Abstract
C7H4Br2N2, monoclinic, C2/c (no. 15), a = 42.364(10) Å, b = 3.9052(4) Å, c = 23.783(3) Å, β = 120.984(9)°, V = 3373.2(10) Å3, Z = 16, Rgt
(F) = 0.0415, wRref
(F
2) = 0.1073, T = 298 K.
Crystal structure of Ba6Cd12Mn4SiF48
Authors: Kim Sun Woo 
Published: April 2024

Abstract
Ba6Cd12Mn4SiF48, cubic,

I
m

3
‾

$Im\overline{3}$

(no. 204), a = 12.57060(10) Å, V = 1986.41(5) Å3, Z = 2, Rgt
(F) = 0.0286, wRref
(F
2) = 0.0784, T = 296(2) K.
Simulation study on basic road performance and modification mechanism of red mud modified asphalt mixture
Authors: Wu Duo , Yin Yuxue , Fu Tao , Liu Fuming 
Published: April 2024

Abstract
In order to study the basic road performance and the mechanism of red mud modified asphalt, Marshall test, rut test, freeze-thaw splitting test, and immersion Marshall test were carried out for matrix asphalt mixture and red mud modified asphalt mixture, and molecular simulation technology was introduced to study the mechanism of red mud modified asphalt. The results showed that the penetration rate of red mud modified asphalt was lower than that of the matrix asphalt, and the softening point of asphalt was significantly improved after the addition of red mud, and the mixing of red mud reduced the asphalt ductility greatly. The intensity ratio (test strength ratio; TSR) of the freeze-thaw test of red mud modified asphalt under 3, 5, 7, 9, and 11% was increased by 13.18, 11.22, 13.54, 12.01, and 8.45%, respectively, compared with the matrix asphalt mixture, and the dynamic stability value increased by 127.23, 176.87, 200.99, 96.23, and 12.95%; the residual stability value of the immersion Marshall test increased obviously. Generally, the research of red mud modified asphalt is quite worthy, it can solve the problem of aluminum ore slag and reuse of resources, and provide a new way to extend the industrial chain.
Applying Evidence to the Aspiration for Equity in Children’s Disability Services
Authors: OLeary Noreen , Moran Geraldine 
Published: April 2024

Developmental disability is a universal issue, affecting millions of children, adolescents and families globally. Many children and young people will require access to and support from disability services. Development of such services has often been piecemeal and requiring reconfiguration, which is a complex process. The aim of this research was to evaluate the evidence-base underpinning the programme of disability reconfiguration in Ireland. A review of relevant policy documents highlighted limited analysis of research and practice evidence to inform policy development and implementation. Many challenges have arisen during reconfiguration such as lengthy waiting lists and high staff turnover. While there are plans in train to increase disability resourcing, it is contended that a root and branch review of the underlying policy is undertaken, with a focus on integrating best available research and practice evidence.
The Relationship Between Crown Shape and Root Canal Morphology of Maxillary Second Molars in an Iraqi Sub-population Using Cone Beam Computed Tomography (CBCT)
Authors: Ibrahim Rawa 
Published: April 2024

Objective: This study aimed to look into how crown shape affected the architecture of the root canals.
Methods: Nine hundred and fifty-four CBCT scans of maxillary second molars were evaluated. The relation between the crown shapeand sex, root number, and root canals was determined. The frequency of the second canal in the mesiobuccal root (MB2), its agerelation, and the symmetry of the concurrence of anatomical variations in contralateral molars were analyzed. The chi-square test wasused for the analysis of the outcomes. It was deemed significant at P< 0.05.
Results: Overall, rhomboidal-shaped crowns comprised 60.1% of all crowns, while heart-shaped crowns made up 39.9%. Three-rootedteeth were the most common (74.5%), followed by two-rooted teeth (11.9%) and one-rooted teeth (8.5%), while four-rooted teeth madeup only 5% of all samples. The most prevalent result in terms of the canal number was three canals (67%), followed by four canals(24.8%), two canals (7.3%), one canal (0.6%), and five canals (0.4%). Males were less likely to have crowns with a heart-shapedstructure than females. The rhomboidal crown (22%) had a higher occurrence of MB2 canals when compared to the heart-shaped crown (2.8%).
Conclusions: Given the constraints of this research, it would seem that the rhomboid form of the upper second molar crown is moreprevalent, with a greater tendency to have three and four roots and the presence of MB2 than the heart-shaped form.
Preliminary Implications of Viscoelastic Ray Theory for Anelastic Seismic Tomography Models
Authors: Borcherdt Roger D. 
Published: April 2024

ABSTRACT
The recent developments in general viscoelastic ray theory provide a rigorous mathematical framework for anelastic seismic tomography. They provide closed-form solutions of forward ray-tracing and simple inverse problems for anelastic horizontal and spherical layered media with material gradients. They provide ray-tracing computation algorithms valid for all angles of incidence that account for changes in wave speed, attenuation, and trajectory of anelastic P and S body waves induced by anelastic boundaries. They account for theoretical predictions that seismic waves refract as inhomogeneous waves across anelastic boundaries for all angles of incidence, which in turn accounts for energy carried by plane waves along seismic boundaries at head wave critical angles and wide-angle refracted (WAR) ray paths that are not predicted by elastic models. Exact viscoelastic ray-tracing numerical results for various models provide examples that illustrate the effects of anelastic boundaries on the travel times and amplitudes of seismic waves. They show the effects are strongly dependent on angle of incidence. For near-critical and wide angles of incidence the anelastic effects on travel times and amplitudes can be large and are not explained by elastic ray theory, but the effects on travel times can be relatively small and difficult to distinguish from those for elastic media for pre-near-critical angles of incidence. The results for some models indicate that reflected anelastic WAR waves may be observable at the surface and possibly account for some prominent seismic arrivals not explained by elasticity. These preliminary results suggest that the application of exact viscoelastic ray-tracing computation algorithms to exploration and teleseismic data sets can reveal new insights regarding the properties and distribution of anelastic materials in the Earth.
Problems of Development of Professional and Public Accreditation of Educational Programs
Authors: Баранова Н.В. , Песоцкий Ю.С. , Дарда И.В. 
Published: April 2024

Рассматриваются актуальные вопросы проведения профессионально-общественной аккредитации. Констатируется, что системообразующий компонент модели профессионально-общественной аккредитации – критерии и показатели, пока не нашли своего должного научного обоснования. Поднимаются вопросы ведения реестра организаций и приводятся результаты анализа сайтов организаций, осуществляющих профессионально-общественную аккредитацию.
The article deals with topical issues of professional and public accreditation. It is stated that the system-forming component of the model of professional and public accreditation – criteria and indicators, have not yet found their proper scientific justification. The issues of maintaining the register of organizations are raised and the results of the analysis of the websites of organizations that carry out professional and public accreditation are presented.
The Problem of Initiation of Thinking in the Theory of Psychological Systems
Authors: Козедуб А.П. 
Published: April 2024

Рассмотрены основные направления исследования инициации мышления, позиции отечественных и зарубежных психологов по данной проблеме. Впервые проанализированы отечественные исследования инициации мышления и предпринята попытка составить целостную картину всевозможных вариантов инициации мышления. Показано, что для полноценного исследования инициации мышления необходимо изучать не только особенности ее детерминации и регуляции, но и специфику структуры мотивообразования и целеобразования. Полученные результаты могут быть использованы в образовательном процессе для повышения интеллектуальной и творческо-поисковой активности обучающихся.
The main directions of research into the initiation of thinking, the positions of domestic and foreign psychologists on this problem are considered. For the first time, domestic research on the initiation of thinking has been analyzed and an attempt has been made to create a holistic picture of all possible options for the initiation of thinking. It is shown that for a full-fledged study of the initiation of thinking, it is necessary to study not only the features of its determination and regulation, but also the specifics of the structure of motive formation and goal formation. The results obtained can be used in the educational process to increase the intellectual and creative search activity of students.