bluuebunny/crossref_metadata_2025_split huggingface dataset:
Markers of Collagen Degradation in Remodeling and Diastolic Dysfunction of Left Ventricle in Patients with Arterial Hypertension
Authors: Shambatov M. A. , Izmozherova N. V. , Popov A. A. , Grishina I. F. , Kudryavtseva E. V. , Bazarnyi V. V. , Polushina L. G. , Kopenkin M. A. 
Published: March 2024

Introduction. Myocardial remodeling is a consequence or predictor of several cardiovascular diseases. The key process in myocardial remodeling is the degradation of collagen fibers, mediated by the activity of matrix metalloproteinases and their tissue inhibitor.The aim of this study was to evaluate serum levels of matrix metalloproteinase type 9 and tissue inhibitor of matrix metalloproteinase type 1 in female patients with arterial hypertension, myocardial remodeling, and diastolic dysfunction.Materials and methods. A cross-sectional study that included 84 postmenopausal women. All patients underwent echocardiography. Left ventricular remodeling was assessed according to Ganau classification, and diastolic function was evaluated using transmittal flow parameters. Serum analysis included the determination of MMP-9 and TIMP-1 levels using an enzyme-linked immunosorbent assay.Results. The median concentration of MMP-9 in the sample was 2 295.00 (923.60–4 114.00) ng/ml, TIMP — 1–17 010.00 (16 780.00–17 170.00) ng/ml. When evaluating the echocardiographic parameters of the patients included in the study, changes were revealed that indicate structural and functional remodeling of the LV and DD. 29 patients (35 %) had normal geometry, 6 patients (7 %) had concentric myocardial remodeling, 21 patients (25 %) had concentric myocardial hypertrophy, 28 cases (33 %) had eccentric myocardial hypertrophy. Statistically significant changes in the activity of MMP-9 and TIMP-1 were revealed in patients with various structural and geometric variants of remodeling. DD was detected in all patients included in the study: I degree was detected in 25 patients (30 %), II degree was determined in 59 cases (70 %). Using one-way analysis of variance, statistically significant differences in the level of MMP-9 in patients with grades I and II DD were determined. MMP-9 and MMP-9/TIMP-1 in patients with grade II DD are significantly higher than in patients with grade I.Discussion. Under pathophysiological conditions, the proteolytic properties of MMP-9 contribute to the stimulation of the immune response, initiating pathogenesis and aggravating the progression of the disease. Evaluation of the activity of MMP-9 and TIMP-1 in patients with arterial hypertension may be a marker of myocardial remodeling.Conclusion. An increase in the activity of matrix metalloproteinase type 9 and a decrease in the activity of a tissue inhibitor of matrix metalloproteinases type 1 were revealed in patients with arterial hypertension, myocardial remodeling and LV diastolic dysfunction. The level of MMP-9 is associated with the degree of diastolic dysfunction and the structural-geometric type of LV remodeling.
Possibilities of Transfistula Ultrasound in Predicting Intraoperative Bleeding in Patients with Infected Pancreatic Necrosis
Authors: Remizov S. I. , Andreev A. V. , Durleshter V. M. , Gabriel S. A. , Zasyadko O. V. 
Published: March 2024

Introduction. Assessing the risk of intraoperative bleeding is of great importance in the treatment of patients with infected pancreatic necrosis.The aim of the study — determine the role of transfistula ultrasound in assessing the risk of intraoperative bleeding in patients with infected pancreatic necrosis.Materials and methods. From 2015 to 2019, 193 people with infected pancreatic necrosis were treated at Regional Clinical Hospital No. 2 (Krasnodar). At stage 1, drains of various diameters were installed in all patients; at stage 2, necrotic tissue was removed using transfistula videoscopic necrosequestrectomy in 48 patients (24.9 %). Before performing instrumental necrosequestrectomy, a developed diagnostic method was used — transfistula ultrasound scanning — to determine the relationship between the location of foci of necrosis in the pancreas and blood vessels in 22 patients (11.4 %; group 1); the method was not used in 26 people (13.5 %; group 2).Results. The number of accesses created into the omental bursa was as follows: 141 patients (73.1 %) had 3 accesses, 52 people (26.9 %) had 2 accesses; into the retroperitoneal space: 102 patients (52.8 %) had 2 accesses, 51 people (26.4 %) had 1 access. Transfistula videoscopic necrosequestrectomy was performed 35 and 37 times in groups 1 and 2, respectively (p > 0.05). Transfistula ultrasound scanning to assess the risk of intraoperative bleeding was used 33 times in patients in group 1. In group 1, intraoperative bleeding was observed in 5 patients (23.8 %), in group 2 — in 7 patients (26.9 %) (p > 0.05). The volume of blood loss was (436.0±83.6) and (887.0±41.8) ml in groups 1 and 2, respectively (p < 0.05). There were no cases of death due to intraoperative bleeding in either group.Discussion. Transfistula ultrasound scanning makes it possible to stratify patients: into a high-risk group (with intimate adjacency of necrosis to vessels), medium (at a distance of up to 15 mm) and low-risk (with a distant location). In this regard, interventions in high-risk patients were carried out in the X-ray operating room to allow for endovascular hemostasis, which made it possible to reduce the volume of blood loss, as well as to create a supply of transfusion media in advance to replenish the volume of blood volume.Conclusion. The developed method of direct transfistula ultrasound scanning makes it possible to assess the risk of intraoperative bleeding in patients with infected pancreatic necrosis to achieve timely hemostasis and compensate for acute blood loss.
Correction of the Inflammatory Reaction in the Discrete Model of Acute Post-manipulation Pancreatitis
Authors: Rantsev M. A. , Sarapultsev P. A. , Chupakhin O. N. 
Published: March 2024

Introduction. Acute post-manipulation pancreatitis (APP) is a common complication of endoscopic interventions on the major duodenal papilla of the duodenum. Moderate acute pancreatitis develops more often than severe acute pancreatitis.The purpose of the work is to determine the effect of compound L-17 of the group of substituted thiadiazines on the severity of the inflammatory reaction in moderate severity APP.Materials and methods. The severity of the inflammatory reaction in experimental APP after surgery in rats using the compound L-17 was studied. During this study, laboratory indicators of the severity of the inflammatory reaction were assessed, including the leukocyte count and the level of increase in the concentration of the major interleukins. Furthermore, morphological data was analyzed to allow an assessment of the dynamics of the cellular composition of the inflammatory infiltrate of the pancreas in the APP in the experiment.Results. A decrease in the severity of the inflammatory reaction was shown according to leukocyte count, cytokine concentration, and a morphological study of the inflammatory infiltrate of the pancreas.Discussion. The effectiveness of the proposed surgical technique for the formation of APP has been proven by the development of acute pancreatitis in all animals operated. Most experimental methods for acute pancreatitis have no such effectiveness. The data obtained confirm the opinion of numerous authors that interventions on the major duodenal papilla are a risk factor for the development of APP. The study used the compound L-17, which is a representative of a new group of organic compounds, substituted thiadiazines, which have a disaggregant and anticoagulant effect. The effect of compound L-17 on the hemocoagulation parameters of blood is associated with the anti-inflammatory mechanism of action of compound L-17.Conclusion. Administration of compound L-17 in moderate-severity experimental APP can reduce the severity of the inflammatory reaction.
Experimental Study of the Corrosive and Biocompatible Properties of Bioresorbable Mg-Ca-Zn Alloy Implants
Authors: Gordienko I. I. , Marchenko E. S. , Borisov S. A. , Chernyy S. P. , Tsap N. A. , Shishelova A. A. , Khrustalev A. P. , Butyagin P. I. , Arbuzova S. S. 
Published: March 2024

Introduction. Magnesium and its alloys are used as biodegradable bone implants due to their high biocompatibility, however, the problem of use is rapid biodegradation with loss of strength.The purpose of the study. Experimental evaluation of bioresorbable Mg-Ca-Zn alloy implants in vitro and in bone tissue in vivo, in order to determine the optimal rate of biodegradation, biocompatibility and reparative response of bone tissue.Materials and methods. Samples from the obtained Mg-Ca-Zn alloy were coated in a microarc oxidation bath (MDO), and to further determine the optimal phase composition and surface properties, the samples were kept in an electrolyte. The biodegradation of implants was assessed by the loss of mass of samples in vitro, and the release of gas into bone tissue in vivo, and the biocompatibility and reparative response of bone tissue density.Results. All Mg-Ca-Zn coated samples show reduced weight loss compared to the uncoated sample. Magnesium samples with a 20-minute exposure in electrolyte, in the context of its application in anatomically unloaded areas, showed the optimal rate of biodegradation, biocompatibility and reparative response of bone tissue.Discussion. In our study using the microarc oxidation for control the corrosion resistance samples of magnesium alloy shows good biocompatibility and low corrosion rate. We found 5-fold increase in corrosion resistance in coated implants, compared with uncoated samples.Сonclusion. The results of an experimental evaluation of bioresorbable Mg-Ca-Zn alloy implants in vitro and in bone tissue in vivo showed that Mg-Ca-Zn coated samples demonstrate low weight loss during biodegradation, with minimal gas release into the bone.
Intensity-Duration-Frequency Curves for Flood Prevention in the Republic of Benin
Authors: Attogouinon André , Lawin Agnidé Emmanuel , Akpovi Basile , Deliège Jean-François 
Published: March 2024

In this research, hourly rainfall recorded at 4 synoptic stations in the Republic of Benin over the period from 2006 to 2019 was used to produce intensity-duration-frequency (IDF) curves. The aim is to determine daily rainfall heights of rare frequency and to establish intensity-duration curves for various recurrence periods. To achieve this, a frequency analysis of rainfall data was carried out using the Gumbel law more commonly used in the sub-region. IDF curves were constructed on the basis of extreme rainfall events in short observation series. R software was used to process the data. The results show a drop in the maximum annual intensity of short-duration rainfall at all stations. The lack of data sets for extreme rainfall values for short durations and sufficiently long reference periods underlines the importance of this study. It should be noted, however, that these results are not sufficient to establish a relationship between the gradual variations observed and the phenomenon of climate change.
The impact of Euro 4 automobile emission regulations on the development of technological capabilities in ASEAN countries
Authors: Sharma Pearl 
Published: March 2024

This research evaluates strategies aimed at lowering automobile emissions in the automobile industries of 4 ASEAN countries- Thailand, Indonesia, Malaysia, and the Philippines, with an emphasis on the Philippines’s implementation of Euro 4 gas emission standards. Regulations based on vehicle technology are critical in reducing greenhouse gas emissions. However, restrictions vary based on each country's level of economic development, policy, and technological foundation. Using the example of Euro 4 car emission rules, this research studied the implementation process and strategies of each ASEAN nation. It then examines the responsibilities of the government, foreign automakers, and local suppliers in the Philippines. The findings indicate that the strategies of car manufacturers have had a favorable influence on the technological capabilities of local suppliers.
Factors influencing consumers’ continuance usage intention toward Food Delivery Apps during COVID-19 in Bangladesh
Authors: Sharif Raihan , Barua Amit 
Published: March 2024

The aim of this research is to identify the factors that are crucial to formulating consumers’ attitude toward using food delivery apps (FDAs) continuingly during the coronavirus pandemic. Due to the pandemic, the catering enterprises changed their way of doing business significantly and gone through a digital transformation to survive. Consequently, this marked a shift in consumers’ attitude towards FDAs. To understand the shift and how consumers’ technological and mental perceptions are contributing to continuance usage intentions, a hypothetical model was proposed using variables from Unified Theory of Acceptance and Use of Technology (UTAUT), Expectancy Confirmation Model (ECM) and the Task-Technology fit Model. A structured questionnaire was used to collect feedback from the repeat users of the FDAs through online social media sites and food review groups. In total 198 valid responses were gathered and analyzed. Structural Equation Modeling (SEM) through AMOS 26 was utilized to test the proposed model fit. Some items in the constructs had to be dropped off to make the model fit. Initially four hypotheses were proposed. Among them only two were validated. The outcomes show that satisfaction and social influence have significant positive impact in determining continuance usage intention toward FDAs among Bangladeshi consumers. While perceived Task-technology fit and trust have non-significant relationship with consumers’ continuance intention. These insights might prove helpful for both online food aggregators and catering businesses in designing marketing plan and formulating effective strategies to build a sustainable consumer base. Future research can extend the model by adding more variables to understand relevant technology’s continuance usage intention. This paper is a unique contribution to the existing literature on FDA continuance intention on coronavirus emergency because no previous studies were undertaken to investigate Bangladeshi consumers. So, this is an original piece of work according to the best of the researchers’ knowledge
HOW DO CUSTOMERS PAY FOR THEIR ONLINE FOOD PURCHASES? A Study on the Online Food Purchasers in Bangladesh
Authors: Kaniz Fatima  , Yasmin Shakila 
Published: March 2024

This paper investigates the choice of payment methods by online food purchasers in Bangladesh. The objective is to identify the factors influencing the choice of payment methods and factors influencing the choice. Responses are collected from 540 respondents through an online questionnaire survey. Cross-tabulation, frequency analysis, the Chi-square independence test, and binary logistic regression are used for in-depth analysis of the data. Cash on delivery is found to be the most favored method of payment followed by mobile financial services (MFS) and internet banking and/or debit/credit cards. Among the demographic variables, purchasers’ gender showed a significant but weak influence on the choice of payment method. MFSs are the most preferred payment method for men. A larger percentage of women prefer the cash-on-delivery method. The use of debit/credit cards is more prevalent among the female purchasers. Other demographic variables such as household income, age, and profession did not portray any significant influence on the choice of payment method. However, frequent buyers are found to prefer online payment (MFS, card, or internet banking) to occasional buyers. The findings of the study contribute to business literature by shedding light on an inadequately tapped area of research. Factors identified to be significant in the choice of payment methods will help online food traders address issues related to their business process and effectively communicate the improvements they can make. The findings of the study may also instigate the financial service providers to be motivated to focus on educating customers about online payment systems and their built-in security.
The Effect of Lending Decision Quality on the Performance of Shariah Based Banks: Empirical Evidence from Bangladesh
Authors: Saha Ratul Kumar 
Published: March 2024

The study tries to find how lending decision quality impacts the financial performance of shariah-based banks from a Bangladeshi perspective. A strongly balanced panel data set of seven shariah-based banks from 2009 to 2021 have been used to run the econometric model required for this paper. The study uses the total classified loan to total loans (CLTL), Provision maintained to total loan (PLTL), Provision Maintained to Classified Loan (PMCL), and Capital Adequacy Ratio (CAR) as a proxy for lending decision quality, whereas the return on asset (ROA) and Net interest margin (NIM) serves the role of performance indicator. Bank Size is also used here as a control independent variable. This paper finds that both CLTL and Bank Size have a significant negative relationship with profitability, and PMCL shows a positive impact on performance. The study does not find any meaningful relationship between CAR and PLTL with bank performance. The contribution from this study suggests that any additional nonperforming loan strain on the shariah-based banking system could result in catastrophic implications such as a negative return or a capital deficiency.
Completude registros de Leishmaniose Tegumentar Americana em São Luís, Maranhão, Brasil
Authors: Magalhães Otávio de Oliveira , Araújo João Guilherme Nantes , Sousa Joicy Cortez de Sá , Aliança Amanda Silva dos Santos 
Published: March 2024

A Leishmaniose Tegumentar Americana (LTA) é classificada pelo Ministério da Saúde como uma doença de notificação compulsória. Objetivo avaliar a completude de dados das fichas de notificação presentes no Sistema de Informação de Agravos de Notificação da LTA no municipío de São Luís, Maranhão, no período de 2019 a 2022. É um estudo epidemiológico quantitativo, que utilizou os dados secundários disponibilizados no SINAN. Para avaliar a completude dos dados foram analisadas 11 variáveis, quatro de preenchimento essencial e sete obrigatórias. A análise das variáveis de preenchimento essencial obtiveram um escore classificado com “Bom”, mas a variável zona de residência apresentou escore “muito baixa”. Com relação às de preenchimento obrigatório, apenas uma variável apresentou escore “muito baixa”, a “classificação epidemiológica”. A completude das fichas de registros de notificação dos casos de LTA em geral foi considerada como boa, porém duas variáveis apresentaram completude muito baixa ou incompletas, demonstrando assim que pode ocorrer mais melhorias na qualidade de informações relacionadas a LTA.
PENGARUH PRODUK DAN PROMOSI TERHADAP KEPUTUSAN BERKUNJUNG SERTA DAMPAKNYA TERHADAP KEPUASAN WISATAWAN DI MUSEUM PURBAKALA DAYU KABUPATEN KARANGANYAR
Authors: Erwin Erwin Purbosaputro 
Published: March 2024

There are many motivational factors for tourists to be interested and visit a tourist attraction or a tourist destination, these factors consist of various variables. In these conditions a product, promotion, decision of a visit is an important factor that will produce or are expected to meet the tourist's decision. This study aims to determine the effect of products and promotion of visiting decisions and their impact on tourist satisfaction at the Dayu Archaeological Museum in Karanganyar Regency.
The research was conducted with quantitative methods. A sample of 95 tourists from the Dayu Archaeological Museum were taken by accidental sampling. Data collection techniques using questionnaires and data were tested and analized with path analysis and one intervening variable with SPSS.
Based on the results of the analysis of research data it can be concluded that: (1) Products have a positive and significant effect on visiting decisions and their impact on tourist satisfaction, (2) Promotion has a positive and significant effect on visiting decisions and their impact on tourist satisfaction, (3) Visiting decisions have a positive effect and significant to tourist satisfaction.
Keywords : Product, Promotion, visiting decision and tourist satisfaction
Pemanfaatan Ekstrak Air Rebusan pala Sebagai Hand Sanitizer di Masa Pandemi Covid 19
Authors: Sunarni Yassa  , Kartini  , Muslim Andi Yusuf  
Published: March 2024

Pengabdian ini bertujuan untuk menambah referensi pengetahuan tentang fungsi pala terhadap masyarakat desa Tampumia khusunya, dan juga kepada masyarakat secara luas atau secara umum tentang manfaat buah Pala, salah satunya adalah dapat berfungsi sebagai hand sanitizer setelah diolah menjadi ekstrak air rebusan. Pengabdian ini dilaksanakan pada masyarakat petani Pala sebagai bagian dari pelaksanaan tridarma Perguruan Tiinggi, dan berorientasi pada edukasi serta memediasi masyarakat dalam memanfaatkan rempah, yaitu buah menjadi hand sanitizer. Buah pala tersebut diekstrak dalam bentuk air rebusan, kemudian berfungsi sebagai pencegah penyebaran virus corona atau covid 19. Karena selain vaksin, buah Pala dapat pula dimanfaatkan untuk menjaga atau anti virus yang dapat melindungi manusia dari kuman yang membawa penyakit, termasuk virus Coroma., ekstrak air rebusan pala, merupakan langkah awal dalam mencegah terjangkit virus Corona (Covid 19). Buah pala mempunyai banyak manfaat, termasuk untuk kecantikan, dan juga berfungsi sebagai pengobatan pada kesehatan tubuh manusia. Buah Pala pun berfungsi sebagai anti Virus atau Kuman (Hand Sanitizer), dan juga baik untuk pengobatan bagi Kesehatan, misalnya menghilangkan masuk angin, menjaga sistem imun tubuh karena terdapat kandungan berbagai vitamin salah satunya vitamin C. juga dapat mengatasi Insomnia, asam lambung, dapat menyehatkan otak, dan masih banyak manfaat lainnya.
Pelatihan Peningkatan Kapasitas Penyuluh Pertanian dalam Pembuatan Media Penyuluhan di Balai Penyuluhan Pertanian (BPP) Kecamatan Bone-Bone Kabupaten Luwu Utara
Authors: Safaruddin  , Abdul Rais  , Suaedi  
Published: March 2024

Keberhasilan program pembangunan sektor pertanian sangat bergantung kepada peran penyuluh di lapangan melalui pendampingan dan pemberdayaan kepada petani. Penyuluh harus berinovasi menemukan cara-cara baru yang efektif, tidak hanya konvensional. Dorongan dan dukungan dalam bentuk informasi yang lebih banyak, pedoman praktek, dan penguatan yang membuat kemajuan mereka terintegrasi dengan kompetensi baru dalam kehidupan mereka sehari-hari. Materi penyuluhan yang disusun harus memenuhi prasyarat menguntungkan, sesuai dengan teknologi setempat, mudah dimengerti, mudah dicoba dalam skala kecil, dan cepat dapat dirasakan hasilnya. Pengabdian ini dilaksanakan di Balai Penyuluhan Pertanian (BPP) Kecamatan Bone-Bone, Kabupaten Luwu Utara pada hari Kamis tanggal 16 Juni 2022. Metode yang digunakan dalam kegiatan ini adalah metode pelatihan dengan sistem ceramah, curah pendapat dan praktek. Hasil dari pelatihan ini adalah para penyuluh pertanian sebanyak 30 orang yang berasal dari 2 BPP yakni BPP Bone-Bone dan BPP Tana Lili, mampu menyusun media penyuluhan berupa leaflet, brosur, panplet, stiker dan label, baik secara manual maupun secara elektronik dengan menggunakan sarana informasi teknologi (IT) berupa laptop yang diakseskan dengan internet. Media penyuluhan ini nantinya akan digunakan oleh para penyuluh pertanian sebagai media penyuluhan dan bahan ajar kepada kelompok tani agar para petani lebih terbangun kapabilitasnya dalam menerapkan teknologi usahatani sehingga bisa lebih efektif dalam berusahatani dan nantinya dapat meningkatkan kesejahteraan para petani.