bluuebunny/crossref_metadata_2025_split huggingface dataset:
An increase in SNHG5 expression is associated with poor cancer prognosis, according to a meta-analysis
Authors: Huang Qiang , Xia Yi-gui , Huang Yong-jian , Qin Hai-feng , Zhang Qun-xian , Wei Chun-feng , Tang Wu-ru , Liao Yuan 
Published: March 2024

Abstract
Background
He long noncoding RNA small nucleolar host RNA 5 (SNHG5) is highly expressed in many cancers, and there is a notable correlation between the elevated expression of SNHG5 and survival outcome in cancer patients. The objective of this study was to conduct a meta-analysis to evaluate the correlation between SNHG5 expression and the clinical outcome of cancer patients.

Methods
Six relevant electronic databases were exhaustively searched, and, depending on the inclusion and exclusion criteria, appropriate literature was obtained. The Newcastle-Ottawa Scale (NOS) score was utilized to evaluate the quality of the research for every article included, and pertinent data from each study were carefully extracted. Hazard ratios (HRs), odds ratios (ORs) and 95% confidence intervals (CIs) were combined to explore the association of SNHG5 expression levels with cancer prognosis, and sensitivity analyses and assessments of publication bias were also conducted to investigate any possibility in the publication of the studies.

Results
Eleven studies encompassing 721 patients were ultimately collected. When combined, the hazard ratios (HRs) revealed a substantial direct correlation between elevated SNHG5 expression and an unfavourable prognosis for cancer patients (HR = 1.90, 95% CI 0.87–4.15); however, the correlation did not reach statistical significance. Furthermore, high SNHG5 expression was predictive of advanced TNM stage (OR: 1.988, 95% CI 1.205–3.278) and larger tumour size (OR: 1.571, 95% CI 1.090–2.264); moreover, there were nonsignificant relationships between SNHG5 expression and DM (OR: 0.449, 95% CI 0.077–2.630), lymph node metastasis (OR: 1.443, 95% CI 0.709–2.939), histological grade (OR: 2.098, 95% CI 0.910–4.838), depth of invasion (OR: 1.106, 95% CI 0.376–3.248), age (OR: 0.946, 95% CI 0.718–1.247) and sex (OR: 0.762, 95% CI 0.521–1.115).

Conclusion
SNHG5 expression is typically increased in the majority of tumour tissues. Elevated SNHG5 expression may indicate poor prognosis in cancer patients. Therefore, SNHG5 is a promising potential therapeutic target for tumours and a reliable prognostic biomarker.
Analysis of related factors for neuropsychiatric comorbidities in children with epilepsy
Authors: Zhang Xin-Ying , Sun Meng , Wang Jiang-Ya , Du Fang-Fang , Liu Xue-Fei , Wang Ling-Jun , Hou Zhen-De , Cheng Ya-Ying 
Published: March 2024

Abstract
Objective
To analyze the risk factors affecting psychiatric behavior and study the psychobehavioral conditions of children with epilepsy.

Method
We randomly selected and enrolled 294 children with epilepsy who visited and were hospitalized in the pediatric clinic of Hebei General Hospital between January 2017 and January 2022, as the study participants. We comprehensively assessed their cognitive functions using the Gesell development schedule or Wechsler Intelligence Scales. The participants were divided into the study group (n = 123) with cognitive impairment and the control group (n = 171) with normal cognitive functions, for analysis.

Results
There were statistically significant differences between the two groups in disease course, frequency of epilepsy, status epilepticus, and the number of antiseizure medications (ASMs) used (P < 0.05), while there were no statistically significant differences in age, gender, age of onset, form of onset, interictal epileptiform discharge, history of febrile convulsion, and the time from onset to initial visit (P > 0.05). Based on multivariate logistic regression analysis, the course of disease, frequency of onset, status epilepticus and number of ASMs used were identified as high-risk factors for cognitive impairment in children with epilepsy. Similarly, early onset, long course of disease, known etiology, and combination of multiple drugs have a negative impact on behavioral problems, school education, and social adaptability.

Conclusion
The course of disease, the frequency of onset, status epilepticus, and the number of ASMs used are high-risk factors for cognitive impairment in children with epilepsy, which can be prevented and controlled early. When selecting ASMs, their advantages and disadvantages should be weighed. Moreover, the availability of alternative treatment options must be considered. With the help of genomic technology, the causes of epilepsy should be identified as early as possible, and precision medicine and gene therapy for children with epilepsy should be actively developed.
Current evidence regarding alternative techniques for enterocystoplasty using regenerative medicine methods: a systematic review
Authors: Arabzadeh Bahri Razman , Peisepar Maral , Maleki Saba , Esmaeilpur Abianeh Fatemeh , A. Basti Fatemeh , Kolahdooz Ali 
Published: March 2024

AbstractEnterocystoplasty is the most commonly used treatment for bladder reconstruction. However, it has some major complications. In this study, we systematically reviewed the alternative techniques for enterocystoplasty using different scaffolds. A comprehensive search was conducted in PubMed, Embase, and Cochrane Library, and a total of 10 studies were included in this study. Five different scaffolds were evaluated, including small intestinal submucosa (SIS), biodegradable scaffolds seeded with autologous bladder muscle and urothelial cells, dura mater, human cadaveric bladder acellular matrix graft, and bovine pericardium. The overall results revealed that bladder reconstruction using regenerative medicine is an excellent alternative method to enterocystoplasty regarding the improvement of bladder capacity, bladder compliance, and maximum detrusor pressure; however, more large-scale studies are required.
Dropout in online higher education: a systematic literature review
Authors: Rahmani Amir Mohammad , Groot Wim , Rahmani Hamed 
Published: March 2024

AbstractThe increased availability of technology in higher education has led to the growth of online learning platforms. However, a significant concern exists regarding dropout rates in online higher education (OHE). In this ever-evolving landscape, student attrition poses a complex challenge that demands careful investigation. This systematic literature review presents a comprehensive analysis of the literature to uncover the reasons behind dropout rates in virtual learning environments. Following the PRISMA guidelines, this study systematically identifies and elucidates the risk factors associated with dropout in online higher education. The selection process encompassed articles published between 2013 and June 2023, resulting in the inclusion of 110 relevant articles that significantly contribute to the discourse in this field. We examine demographic, course-related, technology-related, motivational, and support-related aspects that shape students’ decisions in online learning programs. The review highlights key contributors to dropout like the quality of the course, academic preparation, student satisfaction, learner motivation, system attributes, and support services. Conversely, health concerns, financial limitations, technological issues, screen fatigue, isolation, and academic workload, emerge as significant limitations reported by online learners. These insights offer a holistic understanding of dropout dynamics, guiding the development of targeted interventions and strategies to enhance the quality and effectiveness of online education.
Does your unwell patient have haemophagocytic lymphohistiocytosis?
Authors: Holloway Amelia , Ahmed Saad , Manson Jessica J 
Published: March 2024

Haemophagocytic lymphohistiocytosis is a severe systemic hyperinflammatory syndrome characterised by dysregulation of immune cells and excessive production of cytokines, also known as a cytokine storm. It has distinctive clinical features with fever, hyperferritinaemia and falling blood counts. In adults, this usually occurs secondary to an underlying driver or trigger including infection, malignancy or rheumatic diseases. Prompt treatment with immunomodulatory therapy, including corticosteroids and the recombinant IL-1 receptor antagonist anakinra, is recommended to switch off the cytokine storm. Etoposide-based regimens are sometimes needed, and newer therapies such as emapalumab and JAK inhibitors are increasingly being used. The incidence of haemophagocytic lymphohistiocytosis has increased significantly over the last 20 years which may partly reflect increased awareness of the condition. Although relatively rare, haemophagocytic lymphohistiocytosis can be encountered by a broad range of hospital physicians, so knowing how to diagnose and treat this condition is essential. This article reviews the pathogenesis, clinical features, causes, diagnosis and treatment of haemophagocytic lymphohistiocytosis to improve physician recognition and management of this condition to improve future patient outcomes.
Dynamic iterative correction algorithm for designing diffractive optical elements
Authors: Hu Chi , Zhang Jin , Jiang Shilei , Sun Guobin 
Published: March 2024

When utilizing the Gerchberg–Saxton (GS) algorithm to design diffractive optical elements, correction coefficients are introduced to improve the quality of the design results. The main design idea is to correct the target information dynamically during the iterative calculation process. The effectiveness of the proposed method is demonstrated through the verification of beam shaping and phase-type hologram designs. Compared to the traditional GS algorithm, the results of beam shaping show that the light intensity nonuniformity and the root-mean-square error (RMSE) of the shaped spot are reduced by an order of magnitude. The results of phase-type holograms show that the reconstructed image’s peak signal-to-noise ratio (PSNR) is improved by about 12 dB. Finally, the paper also discusses the selection of correction coefficients, providing insights into the selection of optimal design correction coefficients. The simulation and experimental results show that the improved algorithm proposed in this paper is not only simple in design but also highly efficient in obtaining a high-quality phase structure, which is of great help in designing high-quality diffractive optical elements.
Validity, reliability, and readability of single-item and short physical activity questionnaires for use in surveillance: A systematic review
Authors: Tcymbal Antonina , Messing Sven , Mait Rachel , Perez Roberto Galindo , Akter Taiyeba , Rakovac Ivo , Gelius Peter , Abu-Omar Karim 
Published: March 2024

Background
Accurate and fast measurement of physical activity is important for surveillance. Even though many physical activity questionnaires (PAQ) are currently used in research, it is unclear which of them is the most reliable, valid, and easy to use. This systematic review aimed to identify existing brief PAQs, describe and compare their measurement properties, and assess their level of readability.

Methods
We performed a systematic review based on the PRISMA statement. Literature searches were conducted in six scientific databases. Articles were included if they evaluated validity and/or reliability of brief (i.e., with a maximum of three questions) physical activity or exercise questionnaires intended for healthy adults. Due to the heterogeneity of studies, data were summarized narratively. The level of readability was calculated according to the Flesch-Kincaid formula.

Results
In total, 35 articles published in English or Spanish were included, evaluating 32 distinct brief PAQs. The studies indicated moderate to good levels of reliability for the PAQs. However, the majority of results showed weak validity when validated against device-based measurements and demonstrated weak to moderate validity when validated against other PAQs. Most of the assessed PAQs met the criterion of being "short," allowing respondents to complete them in less than one minute either by themselves or with an interviewer. However, only 17 questionnaires had a readability level that indicates that the PAQ is easy to understand for the majority of the population.

Conclusions
This review identified a variety of brief PAQs, but most of them were evaluated in only a single study. Validity and reliability of short and long questionnaires are found to be at a comparable level, short PAQs can be recommended for use in surveillance systems. However, the methods used to assess measurement properties varied widely across studies, limiting the comparability between different PAQs and making it challenging to identify a single tool as the most suitable. None of the evaluated brief PAQs allowed for the measurement of whether a person fulfills current WHO physical activity guidelines. Future development or adaptation of PAQs should prioritize readability as an important factor to enhance their usability.
Polymorphisms of the Thy1 (Thymocyte Differentiation Antigen 1) Gene in Candidate IPB D2 Chicken Line
Authors: Putri Nensy Tri , Murtini Sri , Ulupi Niken , Khaerunnisa Isyana , Sumantri Cece 
Published: March 2024

The Thy1 gene is a member of the immunoglobulin superfamily, which is found in many different animals. This gene encodes a Thy1 protein (CD90) which measures 25â€“37 kDa. Although the function of the Thy1 gene is unknown, it is thought to play a crucial role in the immunological response, particularly in the activation of T cells. The goal of this study was to find a variation in the Thy1 gene in IPB D2 Â chickens that might be utilized as candidates for immunoresistance genetic markers. A total of 123 samples from IPB D2 chickens consisting of 38 samples from IPB D2 G0 (basic generation) chickens and 85 samples from IPB D2 G2 (second generation) chickens were used in this study. PCR methods and direct-DNA sequencing were used in this study. Data analysis in this study consisted of genotype frequency, allele frequency, observed heterozigosity, expected heterozygosity, and Hardy-Weinberg equilibrium. The results of the studyÂ discovered two SNPs on the intron (g.2139 CT and g.2542 AG). Four haplotypes were created by combining two SNPs. The g.2139 CTand g.2542 AG were polymorphic, but not in the Hardy-Weinberg equilibrium.
Fermentation of Cocoa Pods Husk Using Turmeric Powder and Aspergillus niger: Effects on Fiber Composition and Antinutrients
Authors: Atmaja I Gede Mahardhika , Ismartoyo Ismartoyo , Natsir Asmuddin , Syahrir Syahriani 
Published: March 2024

Processing of cocoa pods husk (CPH) by fermentation with Aspergillus niger (A. niger) and additional herbs such as turmeric is believed to be able to improve the quality of feed ingredients from plantation byproducts.Â The purpose of this study was to evaluate the effectiveness of the fermentation process using A. niger and the addition of different levels of turmeric in reducing the fiber fraction and antinutrient contents of CPH. Â The experiment used a completely randomized design of eight treatments and three replications.Â The treatments consisted of P0: control; P1: CPH fermented with A. niger; P2, P3 and P4: fermented (CPH + 0.5; 1.0 and 1.5% turmeric powder) with A. niger; P5, P6 and P7: fermented CPH with A. niger + 0.5; 1.0 and 1.5 % turmeric powder. Variables observed were the fiber composition of CPHÂ as well as antinutrients.Â The results showed that CPH fermentation using A. niger with different levels of turmeric powder significantly reduced the content of fiber fractions, i.e., NDF, ADF, and hemicellulose, compared to that of unfermented CPH.Â For antinutritional content, fermentation using A. niger with different levels of turmeric powder significantly decreased tannin.Â It tended to decrease the lignin content of CPH compared to unfermented CPHs.Â In conclusion, fermentation of CPH using A. niger with an addition of 1.5% of turmeric before the fermentation is the most effective treatment in decreasing the fiber and antinutritional Components In CPH.
Experimental and numerical investigation of nanomaterial-based structural composite
Authors: Kanif Markad , Vivek Patekar , Kishor Kale 
Published: March 2024

Abstract
In this work, we discussed multi-phase composites fabrication and analytical as well as experimental analysis. Shear mixing of multi-walled nanotube (MWCNT) and epoxy is used to create nanocomposites. Ultrasonication, magnetic stirring, and moulding using the hand layup technique were the procedures used for sample preparation. Curing and cutting were performed as well, all in accordance with ASTM standards. This research uses an experimental method for assessing material qualities and backs up its findings with an analytical one for verification. It can be shown that the outcomes of both experiments and analyses are consistent. The structural analysis of a composite sample is probed by using a further analytical validation strategy. In this research, we examined the effects of varying the MWCNT content of the matrix. The tensile strength was shown to rise up to 0.5% MWCNT content in the matrix. For 0.7% MWCNT reinforcement in the matrix, tensile strength drops as a result of agglomeration. This research also explored the use of ANSYS for critical buckling analysis on many different multi-phase nanocomposite samples. The critical buckling resistance capability of the various configurations of composite materials was examined, and the model’s efficacy was shown via validation against existing literature.
Nephroprotective effect of cranberry (Vaccinium oxycoccos) in streptozocin-induced diabetic nephropathy in mice
Authors: Shareef Saja Majeed , Khaleel Raghad Abdulsalam , Maryoosh Taif M. 
Published: March 2024

Abstract

Objectives
Diabetic nephropathy is a chief reason of mortality particularly in individuals with renal dysfunction. The current research was aimed to assess the nephroprotective portion of Vaccinium oxycoccos toward mice diabetic nephropathy induced by streptozotocin (STZ). V. oxycoccos was purchased and used for hydroalcoholic extraction.

Methods
Sixty male mice were subjected to STZ-intraperitoneal injection (45 mg/kg). After diabetes induction, mice were divided into five groups of diabetic control (received only STZ), non-diabetic control (received only citrate buffer), two V. oxycoccos treatment (received V. oxycoccos extract (200 and 400 mg/kg) oral daily by gavage), and metformin treatment (received metformin (500 mg/kg) oral daily by gavage). Glucose and weight of mice were checked weekly.

Results
After 28 days, the effect of V. oxycoccos extract on serum and urine parameters were assessed. STZ caused significant decreased in the mice body weight. Mice treated with the V. oxycoccos (400 mg/kg) harbored the lowest weight loss at day 28 (70.2±1.38 g). STZ caused significant increase in the mice FBS. Mice treated with the V. oxycoccos (400 mg/kg) harbored the lowest FBS at day 28 (189.2±1.20 mg/dL). Treatment of mice with V. oxycoccos (400 mg/kg) caused the lowest increase in the levels of cholesterol, HbA1c and triglycerides compared to the diabetic control mice. Compared to the diabetic control group, mice treated with V. oxycoccos (400 mg/kg) had the highest HDL, insulin, SOD, and GSH (p<0.05). The lowest serum BUN, CR, and UR were found in mice treated with V. oxycoccos (400 mg/kg). Anti-inflammatory effects of V. oxycoccos (400 mg/kg) was shown by the lowest TNF-α, IL-6, and TGF-β1 concentration in mice treated with V. oxycoccos (400 mg/kg).

Conclusions
The current study disclosed that treatment with V. oxycoccos resulted in substantial development in the serum and urine parameters and also antioxidant and anti-inflammatory response of STZ-induced diabetic mice.
A study on influence of wettability on antiviral coating using polyethylene glycol (PEG) and acrylic binder
Authors: Subramaniam Reasmyraj R. , Syafiq Amirul , Balakrishnan Vengadaesvaran , Ahmad Muhammad Shakeel , Abd Rahim Nasrudin , Hassandarvish Pouya 
Published: March 2024

Abstract
One of the biggest problems facing medical science today is preventing viral outbreaks, which highlights the significance of research initiatives aimed at creating antimicrobial coatings for a range of products, including textiles, medical devices, and public spaces. In this study, we aimed to determine the possible antiviral effects of polyethylene glycol (PEG) coating on feline coronavirus (FCoV). The PEG coatings were synthesized by a simple mixing method with a water-based acrylic binder in different weight percentages (3, 5, 10, 15, 20, and 25 wt%). The Spearman–Karber technique was used to calculate the viral titers, which were then expressed as the tissue culture infectious dose at 50 % CPE (TCID50/ml). 20 wt% PEG could result in a 3 log10 reduction in virus titer with an inhibition rate of approximately 99.9 % against FCoV. The increment of PEG weight percent from 0 to 25 wt% decreases the hardness and glass transition temperature of the coatings from 38.1 to 5.5 HV and 15.45 to −15.48 °C. Apart from that, the wettability analysis has revealed that PEG coating is hydrophilic with water contact angle (WCA) of around 75 ± 0.5°–85 ± 0.5°. Adding 25 wt% of PEG makes the coating to be superhydrophilic with WCA of 39.85 ± 0.5°.
Outcomes of minimal access cytoreductive surgery (M-CRS) and HIPEC/EPIC vs. open cytoreductive surgery (O-CRS) and HIPEC/EPIC in patients with peritoneal surface malignancies: a meta-analysis
Authors: Pawar Ajinkya , Warikoo Vikas , Salunke Abhijeet , Sharma Mohit , Pandya Shashank , Bhardwaj Amol , KS Sandeep , Aaron Jebin 
Published: March 2024

Abstract

Introduction
Minimal Access Surgery (MAS) has shown better peri-operative outcomes with equivalent oncological outcomes in gastrointestinal and thoracic oncology. Open CRS (O-CRS) procedure accompanies inevitable and significant surgical morbidity in patients. The aim of the review article is to compare outcomes of M-CRS and HIPEC/EPIC with open procedure in peritoneal surface malignancies.

Content
Comprehensive search of databases was done and total 2,807 articles were found (2793-PubMed and 14-Cochrane review). PRISMA flow chart was prepared and 14 articles were selected. Meta-analysis was performed according to PRISMA guidelines using random-effects model (DerSimonian Laird) and fixed effect model. Publication bias was tested with Funnel plot and Egger’s regression test. Quality of studies was assessed by Newcastle–Ottawa scale.

Summary and Outlook
Patients in both groups [total (732), M-CRS(319), O-CRS(413)] were similar in demographic characteristics. Peri-operative outcomes were significantly better in M-CRS group in terms of blood loss SMD=−2.379, p<0.001 (95 % CI −2.952 to −1.805), blood transfusion RR=0.598, p=0.011 (95 % CI 0.402 to 0.889), bowel recovery SMD=−0.843, p=0.01 (95 % CI −1.487 to −0.2), hospital stay SMD=−2.348, p<0.001 (95 % CI −3.178 to −1.519) and total morbidity RR=0.538, p<0.001 (95 % CI 0.395 to 0.731). Duration of surgery SMD=−0.0643 (95 % CI −0.993 to 0.865, p=0.892) and CC0 score RR=1.064 (95 % CI 0.992 to 1.140, p=0.083) had no significant difference. Limited studies which evaluated survival showed similar outcomes. This meta-analysis shows that M-CRS and HIPEC/EPIC is feasible and has better peri-operative outcomes compared to open procedure in patients with limited peritoneal carcinoma index (PCI) peritoneal surface malignancies. Survival outcomes were not calculated. Further studies are warranted in this regard.