bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epidemiology of coccidioidomycosis in Argentina, an update
Authors: Viale Mariana Noelia , López-Joffre María Cecilia , Motter Andrea Nora , Mansilla Patricia Evangelina , Vivot Flavia Gisele , Muise Acevedo Facundo Manuel , David Viviana del Valle , Carrizo Silvia Guadalupe , Serrano Julián , Chacón Yone , Miranda Patricia Carola , Alvarez Christian , Colombres María Sofía , Riera Fernando , Dávalos Florencia , Fernández Norma , Fernández Analía , Posse Gladys , Fraenza Laura , Giordano Alejandrina , Ampuero Adela , Amigot Susana , Guelfand Liliana , Formosa Patricia , Machain Mónica , Saavedra Romina , Giusiano Gustavo , Toranzo Adriana Inés , Canteros Cristina Elena 
Published: March 2024

Abstract
The National Reference Laboratory in Clinical Mycology of Argentina conducted a retrospective review of human coccidioidomycosis cases diagnosed by the National Mycology Laboratory Network of Argentina between 2010 and 2022 to determine the burden of the disease in the country. A total of 100 human coccidioidomycosis cases were documented, with a higher prevalence in male patients (male-to-female ratio of 1.9:1), with a median age of 41 years. Comparing the number of cases between two 10-year periods (2000–2009 and 2010–2019), the increase was 36.51% (from 63 to 86 cases). Among the 100 recorded cases, 79 tested positive using the double immunodiffusion test. Spherules were observed in 19 cases through histopathology or direct microscopic examination and the fungus was isolated in 39 cases. Thirty-six isolates were identified as Coccidioides posadasii through partial sequencing of the Ag2/PRA gene. Catamarca province had the highest number of cases, comprising 64% of the total, with an incidence rate above 1.0–2.5/100,000 inhabitants until 2018. However, there has been a recent downward trend in the region from 2018 to 2022. It is concerning that more than half of diagnosed cases were chronic pulmonary or disseminated forms, indicating a lack of early disease detection. To rectify this issue, it is imperative to conduct targeted training programs for healthcare personnel and enhance public awareness within the endemic area. This will contribute to a better understanding of the true burden of coccidioidomycosis and enable the implementation of appropriate sanitary control measures.
The Physics of Indirect Estimators of Lyman Continuum Escape and their Application to High-Redshift JWST Galaxies
Authors: Choustikov Nicholas , Katz Harley , Saxena Aayush , Cameron Alex J , Devriendt Julien , Slyz Adrianne , Rosdahl Joki , Blaizot Jeremy , Michel-Dansac Leo 
Published: March 2024

ABSTRACT
Reliable indirect diagnostics of LyC photon escape from galaxies are required to understand which sources were the dominant contributors to reionization. While multiple LyC escape fraction (fesc) indicators have been proposed to trace favourable conditions for LyC leakage from the interstellar medium of low-redshift ‘analogue’ galaxies, it remains unclear whether these are applicable at high redshifts where LyC emission cannot be directly observed. Using a library of 14 120 mock spectra of star-forming galaxies with redshifts 4.64 ≤ z ≤ 10 from the SPHINX20 cosmological radiation hydrodynamics simulation, we develop a framework for the physics that leads to high fesc. We investigate LyC leakage from our galaxies based on the criteria that successful LyC escape diagnostics must (i) track a high-specific star formation rate, (ii) be sensitive to stellar population age in the range 3.5–10 Myr representing the times when supernova first explode to when LyC production significantly drops, and (iii) include a proxy for neutral gas content and gas density in the interstellar medium. O32, ΣSFR, MUV, and H β equivalent width select for one or fewer of our criteria, rendering them either necessary but insufficient or generally poor diagnostics. In contrast, UV slope (β), and E(B − V) match two or more of our criteria, rendering them good fesc diagnostics (albeit with significant scatter). Using our library, we build a quantitative model for predicting fesc based on direct observables. When applied to bright z &gt; 6 Ly α emitters observed with JWST, we find that the majority of them have $f_{\rm esc} \lesssim 10~{{\ \rm per\ cent}}$.
Genetic diversity, demography and connectivity in the marine snail Thaisella chocolata (Duclos, 1832): implications for sustainable fisheries management along the Peruvian coast
Authors: Louis Victoria , Kochzius Marc , Jiménez Juana , Fourdrilis Séverine , Yamashiro Carmen , Jossart Quentin 
Published: March 2024

ABSTRACT
Thaisella chocolata is a marine gastropod (family Muricidae) occurring from northern Peru to central Chile. It is of economic importance in these countries, where hundreds of tons are caught every year. In combination with El Niño–Southern Oscillation events, fishing activity has led to the collapse of Chilean populations, raising concerns about the state of Peruvian populations. The aim of this study is to assess the demography, genetic diversity and connectivity of T. chocolata along the Peruvian coast. This would provide important insights into the resilience of this species to anthropogenic disturbance. In this study, four locations along the coast of Peru were investigated for the first time. Mitochondrial cytochrome c oxidase subunit I (COI) sequences were obtained from 116 individuals and four microsatellites from 95 individuals. Both COI (combined with 156 publicly available sequences) and microsatellite data revealed very low genetic differentiation, despite a few significant φST and FST values between population pairs. The most likely gene flow model (MIGRATE-N) is panmixia between all locations, with gene flow occurring equally northwards and southwards. This pattern may be related to the surface currents along the Peruvian coastline combined with the high pelagic larval duration of T. chocolata. Hyperdiversity was found for the COI marker (πsyn &gt; 5%). Microsatellite loci were also polymorphic, with a mean diversity of 12.69 alleles per locus per population. No recent population bottleneck was observed (microsatellite data), while at least one past demographic expansion was suggested (COI data). Given the high genetic diversity and connectivity, T. chocolata is expected to show high evolutionary resilience and can be considered as one management unit in terms of fisheries management. However, further studies, on, for example, the characterization of effective population size (using numerous nuclear loci), are required to confirm this hypothesis. In addition, precautionary fisheries measures should be maintained, given the recent collapse of T. chocolata stocks in Chile.
Post-renal acute kidney injury complicated by urinary tract obstruction due to massive blood clots and severe thrombocytopenia in a patient with systemic lupus erythematosus: A case report
Authors: Fujita Yuya , Sato Shuzo , Yoshida Shuhei , Asano Tomoyuki , Matsumoto Haruki , Temmoku Jumpei , Matsuoka Naoki , Ohkawara Hiroshi , Shakespear Norshalena , Migita Kiyoshi 
Published: March 2024

ABSTRACT
Systemic lupus erythematosus (SLE) is often seen with antiphospholipid antibody syndrome (APS), and these conditions may occur concurrently with severe immune thrombocytopenia (ITP) and even acute kidney injury (AKI); however, post-renal AKI due to bleeding is uncommon. Here, we describe a case of post-renal AKI and anuria in a patient with SLE and APS, which were attributable to urinary tract obstruction due to massive blood clots caused by secondary ITP. A 50-year-old Japanese woman was admitted to our hospital with anuria, abdominal tenderness, purpura in the trunk and in both legs, and severe thrombocytopenia. She had been receiving medical treatment for APS and SLE till the age of 45 years. Computed tomography revealed a blood clot without extravasation in both urinary tracts, and she was diagnosed with post-renal AKI due to complete obstruction of the urinary system. Additionally, based on her medical history, elevated platelet-associated Immunoglobulin G (IgG) levels, and increased megakaryocyte count, she was diagnosed with secondary ITP complicated by SLE and APS. She also had elevated APS-related autoantibodies, including antiphosphatidylserine/prothrombin Immunoglobulin M (IgM), and IgG. However, concomitant serositis such as lupus enteritis or cystitis was not seen. She was treated with a combination of glucocorticoids, intravenous immunoglobulin, and continuous haemodialysis/haemofiltration, which resulted in rapid improvement of her symptoms and renal dysfunction. Secondary ITP-induced massive bleeding of urinary tract can cause post-renal AKI. Appropriate diagnosis and aggressive treatment are necessary to improve prognosis in such patients.
CO2-facilitated upcycling of polyolefin plastics to aromatics at low temperature
Authors: Ding Yi , Zhang Shuchi , Liu Cheng , Shao Yu , Pan Xiulian , Bao Xinhe 
Published: March 2024

ABSTRACT
Plastics are one of the most produced synthetic materials and largest commodities, used in numerous sectors of human life. To upcycle waste plastics into value-added chemicals is a global challenge. Despite significant progress in pyrolysis and hydrocracking, which mainly leads to the formation of pyrolysis oil, catalytic upcycling to value-added aromatics, including benzene, toluene and xylene (BTX), in one step, is still limited by high reaction temperatures (&gt;500°C) and a low yield. We report herein CO2-facilitated upcycling of polyolefins and their plastic products to aromatics below 300°C, enabled by a bifunctional Pt/MnOx-ZSM-5 catalyst. ZSM-5 catalyzes cracking of polyolefins and aromatization, generating hydrogen at the same time, while Pt/MnOx catalyzes the reaction of hydrogen with CO2, consequently driving the reaction towards aromatization. Isotope experiments reveal that 0.2 kg CO2 is consumed per 1.0 kg polyethylene and 90% of the consumed CO2 is incorporated into the aromatic products. Furthermore, this new process yields 0.63 kg aromatics (BTX accounting for 60%), comparing favorably with the conventional pyrolysis or hydrocracking processes, which produce only 0.33 kg aromatics. In this way, both plastic waste and the greenhouse gas CO2 are turned into carbon resources, providing a new strategy for combined waste plastics upcycling and carbon dioxide utilization.
Statewide Cancer Drug Repository Reducing Waste in the Setting of Shortage Crisis
Authors: Mackler Emily R , Norman Siobhan , Jalloul Farah 
Published: March 2024

Abstract
Disparities in cancer treatment, including access to medications, continue to exist. Rising drug prices and cancer drug shortages are 2 causes of inequitable access to treatment. This article introduces pilot outcomes for a solution to improve access to medications while also decreasing medication waste. Cancer drug repositories are an innovative patient-centered model where donations of unused cancer medications from patients are repurposed and provided to patients who are most vulnerable and disproportionately harmed by financial toxicity. This model demonstrates efficiency and sustainability that complements integrated care and provides an approach to increase medication access and decrease medication waste.
The biogenesis and maintenance of PSII: Recent advances and current challenges
Authors: Komenda Josef , Sobotka Roman , Nixon Peter J 
Published: March 2024

Abstract
The growth of plants, algae, and cyanobacteria relies on the catalytic activity of the oxygen-evolving PSII complex, which uses solar energy to extract electrons from water to feed into the photosynthetic electron transport chain. PSII is proving to be an excellent system to study how large multi-subunit membrane-protein complexes are assembled in the thylakoid membrane and subsequently repaired in response to photooxidative damage. Here we summarize recent developments in understanding the biogenesis of PSII, with an emphasis on recent insights obtained from biochemical and structural analysis of cyanobacterial PSII assembly/repair intermediates. We also discuss how chlorophyll synthesis is synchronized with protein synthesis and suggest a possible role for PSI in PSII assembly. Special attention is paid to unresolved and controversial issues that could be addressed in future research.
Comprehensive transcriptional atlas of human adenomyosis deciphered by the integration of single-cell RNA-sequencing and spatial transcriptomics
Authors: Chen Tao , Xu Yiliang , Xu Xiaocui , Wang Jianzhang , Qiu Zhiruo , Yu Yayuan , Jiang Xiaohong , Shao Wanqi , Bai Dandan , Wang Mingzhu , Mei Shuyan , Cheng Tao , Wu Li , Gao Shaorong , Che Xuan 
Published: March 2024

Abstract
Adenomyosis is a poorly understood gynecological disorder lacking effective treatments. Controversy persists regarding “invagination” and “metaplasia” theories. The endometrial-myometrial junction (EMJ) connects the endometrium and myometrium and is important for diagnosing and classifying adenomyosis, but its in-depth study is just beginning. Using single-cell RNA sequencing and spatial profiling, we mapped transcriptional alterations across eutopic endometrium, lesions, and EMJ. Within lesions, we identified unique epithelial (LGR5+) and invasive stromal (PKIB+) subpopulations, along with WFDC1+ progenitor cells, supporting a complex interplay between “invagination” and “metaplasia” theories of pathogenesis. Further, we observed endothelial cell heterogeneity and abnormal angiogenic signaling involving vascular endothelial growth factor and angiopoietin pathways. Cell-cell communication differed markedly between ectopic and eutopic endometrium, with aberrant signaling in lesions involving pleiotrophin, TWEAK, and WNT cascades. This study reveals unique stem cell-like and invasive cell subpopulations within adenomyosis lesions identified, dysfunctional signaling, and EMJ abnormalities critical to developing precise diagnostic and therapeutic strategies.
Risk attitude, innovativeness, and financial literacy—A cross-occupational comparison of German farmers and foresters
Authors: Michels Marius , Rieling Jonas Adrian , Musshoff Oliver 
Published: March 2024

Abstract
Factors such as risk attitude, innovativeness, and financial literacy are crucial in agricultural and forest economics, especially amidst weather and market risks. Hence, understanding them is central for fostering a resilient primary sector. We surveyed 371 German farmers and 215 foresters in 2022 online. Both groups were financial literate, reported a neutral generalized risk attitude, leaned toward risk aversion in their professional context, were open to innovation, and showed statistically significant differences between contextualized and generalized risk attitude. Unlike foresters, farmers displayed statistically significant differences between their self-reported general and contextualized innovativeness. Among other things, the results highlight the value of context-specific methods in primary sector research. The study showcases a commitment to open science by using a synthetic dataset to make the analysis transparent and allowing for replication while ensuring participant privacy through the differential privacy framework.
Considering Decoupled Phenotypic Diversification Between Ontogenetic Phases in Macroevolution: An Example Using Triggerfishes (Balistidae)
Authors: Dornburg Alex , Zapfe Katerina L , Williams Rachel , Alfaro Michael E , Morris Richard , Adachi Haruka , Flores Joseph , Santini Francesco , Near Thomas J , Frédérich Bruno 
Published: March 2024

Abstract
Across the Tree of Life, most studies of phenotypic disparity and diversification have been restricted to adult organisms. However, many lineages have distinct ontogenetic phases that differ from their adult forms in morphology and ecology. Focusing disproportionately on the evolution of adult forms unnecessarily hinders our understanding of the pressures shaping evolution over time. Non-adult disparity patterns are particularly important to consider for coastal ray-finned fishes, which can have juvenile phases with distinct phenotypes. These juvenile forms are often associated with sheltered nursery environments, with phenotypic shifts between adults and juvenile stages that are readily apparent in locomotor morphology. Whether this ontogenetic variation in locomotor morphology reflects a decoupling of diversification dynamics between life stages remains unknown. Here we investigate the evolutionary dynamics of locomotor morphology between adult and juvenile triggerfishes. We integrate a time-calibrated phylogenetic framework with geometric morphometric approaches and measurement data of fin aspect ratio and incidence, and reveal a mismatch between morphospace occupancy, the evolution of morphological disparity, and the tempo of trait evolution between life stages. Collectively, our results illuminate how the heterogeneity of morpho-functional adaptations can decouple the mode and tempo of morphological diversification between ontogenetic stages.
Analyzing the training of PAs in ophthalmology
Authors: Gutierrez L. Carlos , Ayars Candace 
Published: March 2024

ABSTRACTObjective:This study sought to determine the role of physician associates/assistants (PAs) in ophthalmology, the balance between barriers and facilitators in training, and optimal training for PAs in ophthalmology.Methods:In this explanatory qualitative case study, 17 of the 94 PAs in ophthalmology in the United States participated in qualitative, semistructured interviews. Qualitative interviews were conducted using a validated interview guide. Interpretational data analysis methods helped in the development of various themes.Results:Themes suggest that PAs play a unique role in assisting ophthalmologists in surgery, performing procedures autonomously, and evaluating and treating patients autonomously. PAs in ophthalmology reported current training programs as unfavorable, reported satisfaction in their careers, and identified formal postgraduate training programs as optimal training for PAs.Conclusions:Findings of this study suggest that formal postgraduate training programs can help PAs gain the necessary skills to successfully fulfill their roles in ophthalmology.
A clinician's guide to pulmonary hypertension
Authors: Wilson Bailey K. , Sadowski Catherine K. , Baeten Robert G. 
Published: March 2024

ABSTRACT
Despite advances in diagnosis and treatment, pulmonary hypertension has high morbidity and mortality. The presenting symptoms often are vague and may mimic other more common diseases, so patients can be misdiagnosed or missed early in the disease process. Early detection of pulmonary hypertension by primary care providers can play an important role in patient outcomes and survival. Identifying signs and symptoms, understanding the causes and classifications, and knowing the systematic approach to evaluating and diagnosing patients with suspected pulmonary hypertension are key to preventing premature patient decline.
Phase 1 Study of Bortezomib, Fludarabine, and Melphalan, With or Without Total Marrow Irradiation, as Allogeneic Hematopoietic Stem Cell Transplant Conditioning for High-risk or Relapsed/Refractory Multiple Myeloma
Authors: Ladbury Colton , Sanchez James , Chowdhury Arnab , Palmer Joycelynne , Liu An , Stein Anthony , Htut Myo , Farol Leonardo , Cai Ji-Lian , Somlo George , Rosenzweig Michael , Wong Jeffrey C. , Sahebi Firoozeh 
Published: March 2024

Objectives:
We conducted a phase 1 study of a conditioning regimen with or without total marrow irradiation (TMI) before allogeneic hematopoietic stem cell transplantation for patients with high-risk or refractory multiple myeloma.

Methods:
Eighteen patients were enrolled on one of 2 strata. Patients with no prior radiation received TMI (900 cGy), fludarabine (FLU), and melphalan (MEL) conditioning, with bortezomib added in the second cohort (stratum I). Patients with prior radiation received FLU, MEL, and bortezomib, without TMI (stratum II).

Results:
Eight patients were enrolled in the TMI arm (stratum I). One of 3 patients in cohort 1 experienced dose-limiting toxicity (DLT), which led to the expansion to 3 more patients with no DLT. Cohort 2 enrolled only 2 patients due to low accrual, with bortezomib, added at 0.5 mg/m2; neither experienced DLT. Nine patients were enrolled in the non-TMI arm (stratum II). Three patients were enrolled in cohort 1 (bortezomib 0.5 mg/m2) and none experienced DLT. Three were enrolled in cohort 2 (bortezomib 0.7 mg/m2), and 1 experienced DLT; therefore, the cohort expanded to 3 more patients. One more patient experienced DLT. Median overall survival on strata I and II was 44.5 months (95% CI: 1.73-not reached) and 21.6 months (95% CI: 4.1-72.7), respectively. Median progression-free survival on strata I and II was 18.1 months (95% CI: 1.73-not reached) and 8.9 months (95% CI: 2.7-24.4), respectively.

Conclusion(s):
TMI 900 cGy, FLU, and MEL are considered feasible as conditioning for allogeneic stem cell transplantation and may warrant further investigation due to favorable response rates and survival.
Estimating the impacts of nonoptimal temperatures on mortality: A study in British Columbia, Canada, 2001–2021
Authors: Shrestha Rudra K. , Sevcenco Ioana , Casari Priscila , Ngo Henry , Erickson Anders , Lavoie Martin , Hinshaw Deena , Henry Bonnie , Ye Xibiao 
Published: March 2024

Background:
Studies show that more than 5.1 million deaths annually are attributed to nonoptimal temperatures, including extreme cold and extreme heat. However, those studies mostly report average estimates across large geographical areas. The health risks attributed to nonoptimal temperatures in British Columbia (BC) are reported incompletely or limit the study area to urban centers. In this study, we aim to estimate the attributable deaths linked to nonoptimal temperatures in all five regional health authorities (RHAs) of BC from 2001 to 2021.

Methods:
We applied the widely used distributed lag nonlinear modeling approach to estimate temperature–mortality association in the RHAs of BC, using daily all-cause deaths and 1 × 1 km gridded daily mean temperature. We evaluated the model by comparing the model-estimated attributable number of deaths during the 2021 heat dome to the number of heat-related deaths confirmed by the British Columbia Coroners Service.

Results:
Overall, between 2001 and 2021, we estimate that 7.17% (95% empirical confidence interval = 3.15, 10.32) of deaths in BC were attributed to nonoptimal temperatures, the majority of which are attributed to cold. On average, the mortality rates attributable to moderate cold, moderate heat, extreme cold, and extreme heat were 47.04 (95% confidence interval [CI] = 45.83, 48.26), 0.94 (95% CI = 0.81, 1.08), 2.88 (95% CI = 2.05, 3.71), and 3.10 (95% CI = 1.79, 4.4) per 100,000 population per year, respectively.

Conclusions:
Our results show significant spatial variability in deaths attributable to nonoptimal temperatures across BC. We find that the effect of extreme temperatures is significantly less compared to milder nonoptimal temperatures between 2001 and 2021. However, the increased contribution of extreme heat cannot be ruled out in the near future.