bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mode‐Selective Spin–Phonon Coupling in van der Waals Antiferromagnets
Authors: Rao Rahul , Selhorst Ryan , Siebenaller Ryan , Giordano Andrea N. , Conner Benjamin S. , Rowe Emmanuel , Susner Michael A. 
Published: March 2024

Abstract2D magnetic materials offer the opportunity to study and manipulate emergent collective excitations. Among these, spin–phonon coupling is one of the most important interactions correlating charge, spin and lattice vibrations. Understanding and controlling this coupling is important for spintronics applications, control of magnons and phonon by THz radiation, and for strain‐driven magnetoelastic applications. Here, a resonant mode‐selective spin–phonon coupling in several magnetic 2D metal thiophosphates (NiPS3, FePS3, CoPS3 and MnPS3) through multi‐excitation and temperature‐dependent Raman scattering measurements is uncovered. The phonon mode, which is a Raman‐active out‐of‐plane vibrational mode (∼250 cm−1 or 7.5 THz), exhibits an asymmetric Fano lineshape where its asymmetry is proportional to the spin–phonon coupling. The measurements reveal the coupling to be the highest in NiPS3, followed by FePS3 and CoPS3, and least in MnPS3. These differences are attributed to the metal–sulfur interatomic distances, which are the lowest in NiPS3, followed by CoPS3, FePS3 and MnPS3. Finally, the spin–phonon coupling is also observed in exfoliated materials, with a slight reduction between 20 and 30% in the thinnest flakes compared to the bulk crystals.
Backward stochastic Volterra integral equations with time delayed generators
Authors: Coulibaly Harouna , Aman Auguste 
Published: March 2024

AbstractIn this paper, we study backward stochastic Volterra integral equations of type‐I with time delayed generators. We derive an existence and uniqueness result under a small time horizon or a small Lipschitz constant. We provide with two example that this condition is necessary. However, this equation has a unique solution for arbitrary time horizon and Lipschitz constant. Finally, with additive assumptions, we derive a path continuity property.
Highly chromophoric fluorescent‐labeled methionyl‐initiator tRNAs applicable in living cells
Authors: Kim Jung Min , Jung Jinho 
Published: March 2024

AbstractFluorescent initiator tRNAs (tRNAi) play a crucial role in studying protein synthesis, yet generating highly fluorescent tRNAi complexes remains challenging. We present an optimized strategy to effectively generate highly fluorescent initiator‐tRNA complexes in living cells. Our strategy allows the generation of Fluo‐Met‐tRNAiMet complexes. These complexes can have highly chromogenic N‐terminal labeling. For generating such complexes, we use either purified fluorescent methionine (PFM) or non‐purified fluorescently labeled methionine (NPFM). Furthermore, PFM promotes the active generation of endogenous tRNAi in cells, leading to highly efficient Fluo‐Met‐tRNAiMet complexes. Finally, PFM‐tRNAiMet complexes also facilitate the visualization of native fluorescently labeled Tat binding to beads. This demonstrates the potential of our approach to advance precision protein engineering and biotechnology applications.
Itaconic acid production by co‐feeding of Ustilago maydis: A combined approach of experimental data, design of experiments, and metabolic modeling
Authors: Ziegler Anita L. , Ullmann Lena , Boßmann Manuel , Stein Karla L. , Liebal Ulf W. , Mitsos Alexander , Blank Lars M. 
Published: March 2024

AbstractItaconic acid is a platform chemical with a range of applications in polymer synthesis and is also discussed for biofuel production. While produced in industry from glucose or sucrose, co‐feeding of glucose and acetate was recently discussed to increase itaconic acid production by the smut fungus Ustilago maydis. In this study, we investigate the optimal co‐feeding conditions by interlocking experimental and computational methods. Flux balance analysis indicates that acetate improves the itaconic acid yield up to a share of 40% acetate on a carbon molar basis. A design of experiment results in the maximum yield of 0.14 itaconic acid per carbon source from 100  glucose and 12  acetate. The yield is improved by around 22% when compared to feeding of glucose as sole carbon source. To further improve the yield, gene deletion targets are discussed that were identified using the metabolic optimization tool OptKnock. The study contributes ideas to reduce land use for biotechnology by incorporating acetate as co‐substrate, a C2‐carbon source that is potentially derived from carbon dioxide.
Theoretical analysis on the formation and nitric oxide release of N‐heterocyclic carbene nitric oxide radicals
Authors: Park Junbeom , Song Hayoung , Lee Yong Ho , Lee Eunsung 
Published: March 2024

AbstractThe theoretical study on the fixation and release of nitric oxide (NO) by N‐heterocyclic carbenes (NHCs) is explored by utilizing a multivariate linear regression approach. We utilized data‐driven tools to establish correlations between molecular descriptors of NHC and reaction outputs of the formation and NO release of NHC nitric oxide radicals (NHCNOs). A key electronic parameter, the singlet‐triplet energy gap (ΔEST), plays a pivotal role in the thermodynamics of NHCNO formation (ΔGf) and NO release (ΔGr). The activation energy models highlight HOMO energy level (EHOMO), C–N bond length (dC–N), and NBO charge on N atom (qNBON) as crucial factors for the formation of NHCNO (ΔG‡f), while the activation energy for the NO release (ΔG‡r) significantly correlates with free energy difference (ΔGr), resulting a strong ΔEST dependency. This study provides valuable insights into the thermodynamics and kinetics of NHCNO processes, offering predictive capabilities to design NHCs tailored for NO release.
Cancer patients with clonal hematopoiesis die from primary malignancy or comorbidities despite higher rates of transformation to myeloid neoplasms
Authors: Chien Kelly S. , Ong Faustine , Kim Kunhwa , Li Ziyi , Kanagal‐Shamanna Rashmi , DiNardo Courtney D. , Takahashi Koichi , Montalban‐Bravo Guillermo , Hammond Danielle , Sasaki Koji , Pierce Sherry A. , Kantarjian Hagop M. , Garcia‐Manero Guillermo 
Published: March 2024

AbstractBackgroundThe occurrence of somatic mutations in patients with no evidence of hematological disorders is called clonal hematopoiesis (CH). CH, whose subtypes include CH of indeterminate potential and clonal cytopenia of undetermined significance, has been associated with both hematologic cancers and systemic comorbidities. However, CH's effect on patients, especially those with concomitant malignancies, is not fully understood.MethodsWe performed a retrospective evaluation of all patients with CH at a tertiary cancer center. Patient characteristics, mutational data, and outcomes were collected and analyzed.ResultsOf 78 individuals included, 59 (76%) had a history of cancer and 60 (77%) had moderate to severe comorbidity burdens. DNMT3A, TET2, TP53, and ASXL1 were the most common mutations. For the entire cohort, the 2‐year overall survival rate was 79% (95% CI: 70, 90), while the median survival was not reached. Of 20 observed deaths, most were related to primary malignancies (n = 7, 35%), comorbidities (n = 4, 20%), or myeloid neoplasms (n = 4, 20%). Twelve patients (15%) experienced transformation to a myeloid neoplasm. According to the clonal hematopoiesis risk score, the 3‐year transformation rate was 0% in low‐risk, 15% in intermediate‐risk (p = 0.098), and 28% in high‐risk (p = 0.05) patients. By multivariate analysis, transformation was associated with variant allele frequency ≥0.2 and hemoglobin <10 g/dL.ConclusionsIn a population including mostly cancer patients, CH was associated with comorbidities and myeloid transformation in patients with higher mutational burdens and anemia. Nevertheless, such patients were less likely to die of their myeloid neoplasm than of primary malignancy or comorbidities.
Benzimidazole and Benzoxazole Derivatives Against Alzheimer's Disease
Authors: Faydalı Nagihan , Arpacı Özlem Temiz 
Published: March 2024

AbstractBenzimidazole and benzoxazole derivatives are included in the category of medical drugs in a wide range of areas such as anticancer, anticoagulant, antihypertensive, anti‐ inflammatory, antimicrobial, antiparasitic, antiviral, antioxidant, immunomodulators, proton pump inhibitors, hormone modulators, etc. Many researchers have focused on synthesizing more effective benzimidazole and benzoxazole derivatives for screening various biological activities. In addition, there are benzimidazole and benzoxazole rings as bioisosteres of aromatic rings found in drugs used in the treatment of Alzheimer's disease. Because of the diverse activity of the benzimidazole and benzoxazole rings and bioisosteres marketed as drugs for Alzheimer Diseases, designed compounds containing these rings are likely to be effective against Alzheimer's disease. In this study, the effectiveness of compounds containing benzimidazole and benzoxazole rings against Alzheimer's disease will be examined.
In vitro Evaluation of Skin Related Enzyme Inhibitory Effect and Emulgel Formulation Development Studies of Onobrychis Argyrea subsp. Argyrea with Phytochemical Analysis
Authors: Şentürk Tuğba Buse , Barak Timur Hakan , Çağlar Emre Şefik , Nath Ebru Özdemir , Özdemir Zafer Ömer 
Published: March 2024

AbstractSpecies of Onobrychis have been used to treat skin disorders such as wounds and cuts in folk medicine and Onobrychis argyrea subsp. argyrea (OA) commonly known as ‘silvery sainfoin’, is a member of this genus. In this study, it was aimed to investigate the skin‐related biological activities and phytochemical characterization of OA. Moreover, an emulgel formulation was developed from the main methanolic extract of the plant (OAM). Initially, to identifiy of the active fractions, aerial parts of the plant material was extracted with methanol and fractionated by n‐hexane, chloroform, ethyl acetate and n‐butanol, respectively. Antioxidant activity was determined by CUPRAC, TOAC, FRAP and DPPH assays. Thereafter, the inhibition potential of OAM, novel formulation and all fractions was measured against elastase, collagenase, tyrosinase and hyaluronidase enzymes. OAM was analyzed and characterized by LC/MS‐MS. The major bioactive flavonoids which are rutin and isoquercetin were measured and compared as qualitative and quantitative via high performance thin layer chromatography (HPTLC) analysis in OAM and fractions. The results showed that extracts of OA can be a potential cosmeceutical agent for skin related problems.
Revolutionizing Infection Control: Harnessing MXene‐Based Nanostructures for Versatile Antimicrobial Strategies and Healthcare Advancements
Authors: Habeeb Naser Israa , Ali Naeem Youssef , Ali Eyhab , Yarab Hamed Amina , Farhan Muften Nafaa , Turky Maan Fadhil , Hussein Mohammed Israa , Mohammad Ali Khalil Noor Alhuda , Ahmad Irfan , Abed Jawad Mohammed , Elawady Ahmed 
Published: March 2024

AbstractThe escalating global health challenge posed by infections prompts the exploration of innovative solutions utilizing MXene‐based nanostructures. Societally, the need for effective antimicrobial strategies is crucial for public health, while scientifically, MXenes present promising properties for therapeutic applications, necessitating scalable production and comprehensive characterization techniques. Here we review the versatile physicochemical properties of MXene materials for combatting microbial threats and their various synthesis methods, including etching and top‐down or bottom‐up techniques. Crucial characterization techniques such as XRD, Raman spectroscopy, SEM/TEM, FTIR, XPS, and BET analysis provide insightful structural and functional attributes. The review highlights MXenes’ diverse antimicrobial mechanisms, spanning membrane disruption and oxidative stress induction, demonstrating efficacy against bacterial, viral, and fungal infections. Despite translational hurdles, MXene‐based nanostructures offer broad‐spectrum antimicrobial potential, with applications in drug delivery and diagnostics, presenting a promising path for advancing infection control in global healthcare.
Mother–daughter technique for kinked catheter retrieval from radial artery
Authors: Panchal Hemang B. , Patel Nirav , Bhogal Sukhdeep , De La Cruz Quezada Kristal 
Published: March 2024

AbstractCatheter kinking is not an uncommon scenario during cardiac catheterization via transradial access in patients with tortuous vascular anatomy. Several noninvasive and invasive methods have been described to unkink and retrieve the kinked catheter out of the vessel. We present a novel mother–daughter technique to retrieve a kinked radial artery catheter.
Intra‐biliary hydatid cyst rupture: A rare case report with superinfection
Authors: Al‐Asbahi Hanan , Jaradat Jaber H. , Abu‐Jeyyab Mohammad , Al‐Dwairi Ruba , Tailakh Bara'a W. , Almadadha Rand A. , Alkhawaldeh Ibraheem M. , Nashwan Abdulqadir J. 
Published: March 2024

Key Clinical MessageHydatid cysts, primarily found in the liver (70%), are caused by parasitic infections and can lead to severe complications such as cyst rupture. This case report describes a unique instance of a hydatid liver cyst occupying the right lobe with a communicating part with the biliary tree that ruptured showing a concurrent superinfection.AbstractHydatid cysts are a clinical pathology resulting from parasitic infections. They may occur in different organs of the body. However, these are mostly found in the liver (70%). This can cause significant complications including cyst rupture. Several case reports have described various hydatid cyst ruptures; however, only a few have reported an intra‐biliary hydatid cyst rupture. A 24‐year‐old male patient presented with right upper quadrant pain, jaundice, dark urine, and pale stool. Imaging studies, including Magnetic resonance cholangiopancreatography (MRCP) and computed tomography (CT), revealed a beavertail liver, cystobiliary communication and intrahepatic biliary tree‐ruptured hydatid cysts. The cyst was in the right liver lobe, which is the most common site for hydatid cysts. Surgical intervention involving laparoscopic de‐roofing and cyst removal resulted in a smooth recovery without complications. Several case reports have described various hydatid cyst ruptures; however, only a few have reported originally placed intra‐biliary hydatid cyst ruptures. This case report describes a unique instance of a hydatid liver cyst occupying the right lobe with a communicating part with the biliary tree that ruptured showing a concurrent superinfection.
A pH‐Responsive Topological Switch Based on a DNA Quadruplex‐Duplex Hybrid
Authors: Vianney Yoanes Maria , Jana Jagannath , Weisz Klaus 
Published: March 2024

AbstractA guanine‐rich oligonucleotide based on a human telomeric sequence but with the first three‐nucleotide intervening stretch replaced by a putative 15‐nucleotide hairpin‐forming sequence shows a pH‐dependent folding into different quadruplex‐duplex hybrids in a potassium containing buffer. At slightly acidic pH, the quadruplex domain adopts a chair‐type conformation. Upon increasing the pH, a transition with a midpoint close to neutral pH to a major and minor (3+1) hybrid topology with either a coaxially stacked or orthogonally oriented duplex stem‐loop occurs. NMR‐derived high‐resolution structures reveal that an adenine protonation is prerequisite for the formation of a non‐canonical base quartet, capping the outer G‐tetrad at the quadruplex‐duplex interface and stabilizing the antiparallel chair conformation in an acidic environment. Being directly associated with interactions at the quadruplex‐duplex interface, this unique pH‐dependent topological transition is fully reversible. Coupled with a conformation‐sensitive optical readout demonstrated as a proof of concept using the fluorescent dye thiazole orange, the present quadruplex‐duplex hybrid architecture represents a potentially valuable pH‐sensing system responsive in a physiological pH range of 7±1.
Amino Acid‐Mediated Formation of Zirconia Nanoparticles and their Transparent Dispersions
Authors: Venier Amandine , Brissaud Charlène , Cormary Benoît , Camposilvan Erik , Alberici Julien , Chateau Denis , Pousin Nora , Chevillot‐Biraud Alexandre , Millot Yannick , Comesaña‐Hermo Miguel 
Published: March 2024

AbstractWe present a straightforward one‐pot hydrothermal method for the synthesis of zirconia nanodispersions, leading to the formation of stable sols. By simply varying the nature of the stabilizer used, one can obtain a large variety of objects with different sizes, shapes and crystallinities. Our results demonstrate the crucial role played by aliphatic amino acids both during the formation of the objects and after, since their interaction with the surface of the inorganic crystals influences strongly the optical properties and colloidal stability of the latter. Importantly, the versatility of this method allows for the introduction of different dopants, increasing substantially the scope of applications that can be achieved with such nanoscale oxides. The high transparencies and the easy dispersibility of nanoparticles in different liquid matrixes ensure the formation of zirconia‐based nanocomposites and ceramics with outstanding optical features for the orthopedic, dental, photonics and chemical sectors. This method can be easily scaled up, being already available for the production of high‐quality zirconia nanodispersions at the industrial level.
Sustainability assessment frameworks for delivering Environmental, Social, and Governance (ESG) targets: A case of Building Research Establishment Environmental Assessment Method (BREEAM) UK New Construction
Authors: Adewumi Ayomikun Solomon , Opoku Alex , Dangana Zainab 
Published: March 2024

AbstractDue to the potential role of the construction industry in addressing the global challenge of climate change, stakeholders are beginning to develop the environmental, social and governance (ESG) framework. Prior to this, several assessment frameworks such as the building research establishment environmental assessment methods (BREEAM), LEED, and Green Star Certification amongst others have evolved to evaluate a development against an array of sustainability indicators. Through document analysis, this paper explores the extent sustainability assessment frameworks can help UK construction companies demonstrate their commitment to ESG targets. Findings show that although the BREEAM assessment framework captured environmental and social aspects to some extent, there appears to be much desired in its consideration for governance issues. Subsequent versions of the assessment frameworks should attempt to include some of these credits that are not currently included in the framework to guarantee stakeholders that the uptake of the framework in the decision‐making process would help to deliver ESG targets.
Loss of the scavenger receptor MARCO results in uncontrolled vomocytosis of fungi from macrophages
Authors: Onyishi Chinaemerem U. , Jeon Yusun , Fejer Gyorgy , Mukhopadhyay Subhankar , Gordon Siamon , May Robin C. 
Published: March 2024

AbstractVomocytosis, also known as nonlytic exocytosis, is a process whereby fully phagocytosed microbes are expelled from phagocytes without discernible damage to either the phagocyte or microbe. Although this phenomenon was first described in the opportunistic fungal pathogen Cryptococcus neoformans in 2006, to date, mechanistic studies have been hampered by an inability to reliably stimulate or inhibit vomocytosis. Here we present the fortuitous discovery that macrophages lacking the scavenger receptor MAcrophage Receptor with COllagenous domain (MARCO), exhibit near‐total vomocytosis of internalised cryptococci within a few hours of infection. Marco−/− macrophages also showed elevated vomocytosis of a yeast‐locked C. albicans strain, suggesting this to be a broadly relevant observation. We go on to show that MARCO's role in modulating vomocytosis is independent of its role as a phagocytic receptor, suggesting that this protein may play an important and hitherto unrecognised role in modulating macrophage behaviour.
Synthesis, Characterization, and Polymorphism of [H3O][NbF6]: A Polar and Possibly Ferroelectric Oxonium Salt
Authors: Möbs Martin , Sachs Malte , Rolheiser Konstantin , Pietzonka Clemens , Karttunen Antti J. , Kraus Florian 
Published: March 2024

Abstract[H3O][NbF6] was obtained from the controlled hydrolysis of NbF5 in anhydrous liquid HF. It adopts a polar, orthorhombic crystal structure with space group Iba2 (no. 45, oI88) at room temperature. A first‐order phase transition at 137 K leads to a cubic non‐centrosymmetric polymorph in space group I213 (no. 199, cI88). This low‐temperature modification results from a distinct rotation of the [H3O]+ cations canceling their polar orientation in the room temperature phase. Quantum‐chemical calculations estimate a rotational barrier between 5.8 to 6.4 kJ/mol. At a temperature of 363 K, the compound adopts a centrosymmetric, cubic crystal structure in space group Pm
m (no. 221, cP11) that shows rotational disorder of cations and anions. The transition from the polar phase at room temperature to the centrosymmetric phase at high temperature not only reveals the plastic nature of the high‐temperature structure but also hints at potential ferroelectric properties, underscoring the multifaceted behavior of [H3O][NbF6] across different temperature regimes.
Assessing the feasibility of a neck‐strength training intervention in university women's rugby
Authors: Petrie Freja J. , Williams Elisabeth M. P. , Mackintosh Kelly A. , Starbuck Chelsea , McNarry Melitta A. 
Published: March 2024

AbstractCervical muscle strength has been demonstrated to reduce concussion risk in high school athletes, and interventions to improve this in male rugby players have elicited strength improvements. However, the feasibility of introducing neck‐strengthening interventions into women's rugby has not been investigated. This study sought to pilot a neck‐strength intervention in university‐level women's rugby players. A fixed‐frame dynamometer was used to assess the multi‐directional isometric neck‐strength of 14 university women's rugby players (20.3 ± 1.0 years). Between baseline and end‐of‐season testing, a neck‐strengthening program was completed. Interviews were conducted with six players and two coaches to understand program engagement. Interviews were transcribed verbatim and processed via inductive content analysis. Increases in absolute neck‐strength post‐intervention in left and right lateral flexion (left 85.4 ± 29.7 N to 108.2 ± 41.6 N, p = 0.02, right 87.4 ± 33.3 N to 110.5 ± 40.3 N, p = 0.01) and flexion (128.4 ± 28.8 N to 147.9 ± 30.5 N, p = 0.01) were perceived positively by the players although there were suggestions that greater adaptability according to training age and more variety was required. Participants initially demonstrated limited awareness of neck‐strength training but engaged well with the exercises once the potential benefits were understood. This intervention shows promise as an effective, palatable strategy to improve neck‐strength in university women's rugby players. Further research is needed to establish whether such improvements in neck‐strength are associated with meaningful reductions in head impact occurrence.