bluuebunny/crossref_metadata_2025_split huggingface dataset:
The ALDH2 gene rs671 polymorphism is associated with cardiometabolic risk factors in East Asian population: an updated meta-analysis
Authors: Liu Ruikang , Peng Miaomiao , Zhang Jiaoyue , Qiu Kangli , Zeng Tianshu , Chen Lulu 
Published: March 2024

IntroductionAcetaldehyde dehydrogenase 2 (ALDH2) had reported as a prominent role in the development of cardiometabolic diseases among Asians. Our study aims to investigate the relationship between ALDH2 polymorphism and cardiometabolic risk factors in East Asian population.MethodWe searched databases of PubMed, Web of Science, and Embase updated to Oct 30th, 2023. We extracted data of BMI, Hypertension, SBP, DBP, T2DM, FBG, PPG, HbA1c, TG, TC, LDL-C and HDL-C.ResultIn total, 46 studies were finally included in our meta-analysis, containing, 54068 GG and, 36820 GA/AA participants. All outcomes related to blood pressure revealed significant results (hypertension OR=0.83 [0.80, 0.86]; SBP MD=-1.48 [-1.82, -1.14]; DBP MD=-1.09 [-1.58, -0.61]). FBG showed a significant difference (MD=-0.10 [-0.13, -0.07]), and the lipid resulted significantly in some outcomes (TG MD=-0.07 [-0.09, -0.04]; LDL-C MD=-0.04 [-0.05, -0.02]). As for subgroups analysis, we found that in populations without severe cardiac-cerebral vascular diseases (CCVDs), GG demonstrated a significantly higher incidence of T2DM (T2DM OR=0.88 [0.79, 0.97]), while the trend was totally opposite in population with severe CCVDs (T2DM OR=1.29 [1.00, 1.66]) with significant subgroup differences.ConclusionOur updated meta-analysis demonstrated that ALDH2 rs671 GG populations had significantly higher levels of BMI, blood pressure, FBG, TG, LDL-C and higher risk of hypertension than GA/AA populations. Besides, to the best of our knowledge, we first report GG had a higher risk of T2DM in population without severe CCVDs, and GA/AA had a higher risk of T2DM in population with severe CCVDs.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO, identifier CRD42023389242.
IN SILICO STUDY : HERMETIA ILLUCENS BASED ACUTE RESPIRATORY INFECTION TREATMENT
Authors: Agsari Sintia Intan Agsari , Alzaini Bychaqi Imam Ali , Tri Wibowo Bintang Aditia 
Published: March 2024

The novel coronavirus is now referred to as severe and critical acute respiratory syndrome coronavirus-2 (SARS-CoV-2). There have been few studies about SARS-CoV-2 co-infection may significantly inhibit the immune system of host, increase antibacterial therapy intolerance, and be harmful to the prognosis of the disease. The highest co infection comes from Streptococcus pneumoniae. Bacterial co-infection in the setting of viral pneumonia is known as major cause of mortality. Therefore, therapeutics such as antibiotics are needed to be able to kill and inhibit these bacteria. In this connection, the inaccurate use of antibiotics causes multi-drug resistant and worsens their immature immune systems. Hermetia illucens contains AMPs and various amino acids that synergistically have the potential to overcome this problem. Research on the use of crude maggot extract as a candidate for acute respiratory infection treatment products is still not available and has never been reported. This study aims to conduct in silico computerized tests related to the potential of maggot extract as antibacterial and anti-inflammatory properties, analyze its interaction with target proteins, bioavailability and ligand toxicity in maggot extract, and docking analysis of ligand-receptor. The results showed that the maggot extract had activity as peptidoglycan glycosyltransferase inhibitor, antibacterial, and anti-inflammatory. A binding affinity of the maggot AMPs ligands (defensin, diptericin, and attacin) to MurC receptor protein Streptococcus pneumoniae is also found. The antibacterial and anti-inflammatory abilities of bioactive maggots have the potential for used as a candidate treatment products for SARS-CoV-2 co-infection with Streptococcus pneumoniae as a biomedical innovation.
Optimal Trafik Denetim Stratejilerinin Belirlenmesinde Çok Kriterli Karar Verme Yaklaşımları
Authors: KILIÇ Buket Nur , ASAL Ömer 
Published: March 2024

Trafik denetim stratejileri, trafik sıkışıklığının azaltılması, ortalama seyahat süresinin azaltılması ve kazaların önlenmesi gibi konularda etkili çözümler sunarak trafik verimliliğini artırmayı hedeflemektedir. Trafik durumunun analiz edilmesi, trafik modellemesi, trafik sinyalizasyon sistemleri, trafik işaretlemeleri ve teknolojik çözümler gibi faktörlerin bir arada kullanılmasıyla en uygun stratejiler belirlenebilmektedir. Bu stratejilerin belirlenmesinde çok kriterli karar verme yaklaşımlarının büyük yararlılık sağladığı görülmektedir. Çok kriterli karar verme, tek bir faktör yerine birden fazla kriter ve hedefe dayalı olarak karar vermek için kullanılan sistematik bir yaklaşımdır. Çok kriterli karar verme, karar vericilerin alternatifleri uygun bir ölçek kullanarak sıralamasına, ilgili tüm faktörlerin dikkate alınmasına ve mümkün olan en iyi seçimin yapılmasına olanak tanımaktadır. Bu önemine karşın literatürde, çok kriterli karar verme yaklaşımlarının trafik denetim stratejilerine etkisine dair yeterli çalışma olmadığı görülmektedir. Trafik olgusunun karmaşık yapısı ve trafiğin insan hayatı için önemi düşünüldüğünde bu konuda yapılacak olan akademik çalışmalara duyulan ihtiyaç oldukça fazladır. Bu çalışmada optimal trafik denetim stratejilerinin belirlenmesinde çok kriterli karar verme yaklaşımlarının rolü incelenecektir. Çalışmada nitel metot kullanılacaktır. Öncelikle konu hakkında literatür taraması yapılacak olup önceki çalışmalardan hareketle, mevcut boşluklar belirlenecektir. Ardından optimal trafik denetim stratejileri ve trafik denetim stratejilerinde kullanılan çok kriterli karar verme yaklaşımları açıklanacaktır. Bu teorik temelden sonra kalitatif ilişkisel analiz ile optimal trafik denetim stratejilerinin belirlenmesinde çok kriterli karar verme yaklaşımları değerlendirilecek ve bazı örnek modeller uygulanacaktır. Çalışmanın amacı; karar destek sistemlerini geliştirmek ve trafik denetim stratejilerinin uygulanması için karar vericilere yardımcı olacak araçlar sağlamaktır. Çalışmanın tezi; çok kriterli karar verme yaklaşımlarının optimal trafik denetim stratejilerinin belirlenmesinde oldukça işlevsel olduğudur.
Anahtar Kelimeler: Trafik, Denetim, Optimizasyon, Çok Kriterli Karar Verme Yaklaşımları, Strateji
Infections of the soft tissues of the perianal region in patients with tumor diseases of the blood system
Authors: Shtyrkova S. V. , Danishyan K. I. 
Published: March 2024

Introduction. The clinical manifestations and approaches to the treatment of infections of the soft tissues of the perianal region developing in oncohematological patients differ signifi cantly from classical cryptogenic anorectal abscesses in immunocompetent patients.Aim. To study the clinical characteristics and results of treatment of various forms of perinatal infections (PI) in patients with tumor diseases of the blood systemMain findings. This review presents variants of clinical forms of the infectious processes in the perianal region in patients with hematological malignancies, treatment methods corresponding to a certain clinical form of infection, and factors affecting prognosis.
Efek Antifungi Sediaan Pasta Gigi Ekstrak Teh Hijau (Camellia sinensis L.) dan Peppermint (Menthapiperita) terhadap Candida albicans
Authors: Wangguai Vannia , Sugiaman Vinna K. , Widowati Wahyu 
Published: March 2024

Abstract: Candida albicans are normal flora of the oral cavity that are opportunistically pathogenic and becomes the main causative agent of oral candidiasis. The addition of herbal ingredients to toothpaste is a solution to resistance and synthetic antifungal side effects. Green tea and peppermint extracts are known to have an antifungal role with various active ingredients such as catechins, tannins, flavonoids, terpenoids, alkaloids, and saponins. This study aimed to determine the antifungal effect of toothpaste preparations of green tea extract and peppermint on C. albicans. This study used the agar diffusion method at several concentrations of green tea and peppermint extracts in toothpaste preparations, namely 1000 mg/ml, 500 mg/ml, 250 mg/ml, 125 mg/ml, 62,5 mg/ml and 31,25 mg/ml. The results showed that there was an antifungal effect of green tea and peppermint extract toothpaste against C. albicans at a concentration of 1000 mg/ml with an average inhibition zone diameter of 7.19 mm. The smallest inhibition zone was 125 mg/ml with a diameter of 1.16 mm. In conclusion, green tea and peppermint extract toothpastes have antifungal effects. The higher the concentration of the extract used in the toothpaste preparation, the greater the antifungal inhibition zone formed.
Keywords: Candida albicans; antifungal toothpaste; green tea; peppermint

Abstrak: Candida albicans merupakan flora normal rongga mulut yang bersifat patogen oportunistik dan menjadi agen penyebab utama kandidiasis oral. Penambahan bahan herbal pada pasta gigi mikroba merupakan solusi terhadap resistensi dan efek samping antijamur sintetik. Ekstrak teh hijau dan peppermint diketahui memiliki peran sebagai antijamur dengan berbagai kandungan aktifnya seperti katekin, tanin, flavonoid, terpenoid, alkaloid dan saponin. Mengetahui efek antifungi sediaan pasta gigi ekstrak teh hijau dan peppermint terhadap C. albicans. Penelitian ini menggunakan metode difusi agar dengan beberapa konsentrasi ekstrak teh hijau dan peppermint dalam sediaan pasta gigi yaitu 1000 mg/ml, 500 mg/ml, 250 mg/ml, 125 mg/ml, 62,5 mg/ml dan 31,25 mg/ml. Hasil penelitian memperlihatkan adanya efek antifungi pada pasta gigi ekstrak teh hijau dan peppermint terhadap C. albicans pada konsentrasi 1000 mg/ml dengan diameter zona hambat rata-rata sebesar 7,19 mm. Zona hambat terkecil dari konsentrasi 125 mg/ml dengan diameter 1,16 mm. Simpulan penelitian ini ialah pasta gigi ekstrak teh hijau dan peppermint memiliki efek antijamur. Semakin tinggi konsentrasi ekstrak yang digunakan dalam sediaan pasta gigi maka semakin besar zona hambat antijamur yang terbentuk.
Kata kunci: Candida albicans; pasta gigi antifungi; teh hijau; peppermint
PENGARUH CUSTOMER SATISFACTION TERHADAP BRAND LOYALTY DENGAN FINANCIAL LITERACY SEBAGAI MODERATOR (STUDI KASUS DI LLS COFFEE)
Authors: Zidane Muhammad , Sita deliyana firmialy  
Published: March 2024

Customer satisfaction is the most important thing in terms of consumer loyalty to a brand. With the financial literacy of Indonesian society still being very small, will the relationship between customer satisfaction and brand loyalty be strengthened or weakened. The research method used in this research is a quantitative research method by distributing questionnaires. The sample from this research was 101 respondents (Generation Z). The data was processed using the IBM SPSS 26 application. The results of this research are that customer satisfaction influences brand loyalty by 34.3%. financial literacy influences brand loyalty by 2.8%. However, financial literacy as a moderation is not able to moderate the influence of customer satisfaction on brand loyalty with an influence of 35.8%.
PENGARUH JOB RESOURCES TERHADAP WORK ENGAGEMENT MELALUI BURNOUT
Authors: Deberina Syurfi Yunina  , Ayu Lucy Larassaty  
Published: March 2024

ABSTRAK
Tujuan dari adanya penelitian ini yaitu berfungsi mengemukakan pengaruh sumber daya pekerjaan terhadap work engagement melalui burnout sebagai variabel intervening. Penelitian ini menggunakan pendekatan kuantitatif dengan menggunakan sampel karyawan produksi PT. Kelompok Cemerlang Plastindo beranggotakan 48 orang. Teknik pengambilan sampel penelitian menggunakan sampel jenuh. Metode analisis data dalam penelitian ini menggunakan analisis parsial. Perangkat lunak yang digunakan adalah SmartPLS versi 4.0. Penelitian menunjukkan bahwa burnout tidak mempengaruhi keterlibatan kerja. Sumber daya pekerjaan tidak berpengaruh terhadap kelelahan. Sumber daya ketenagakerjaan mempengaruhi interaksi kerja. Oleh karena itu, upaya untuk meningkatkan sumber daya ketenagakerjaan mungkin merupakan strategi yang efektif untuk meningkatkan keterlibatan kerja karyawan tanpa secara langsung mengatasi kelelahan. Hasil penelitian diharapkan dapat memberikan kontribusi terhadap pengembangan strategi pengelolaan sumber daya manusia yang lebih efektif untuk meningkatkan work engagement karyawan.

Kata Kunci : Sumber Daya Pekerjaan, Keterikatan Kerja, Burnout
Use of periodic 2D pillar array for performance enhancement of AlN-based SMR BAW resonators
Authors: Luo Hua-yong , Wu Ting , Yang Zi-jiang , Ye Chang-yu , Bao Jing-fu , Hashimoto Ken-ya 
Published: March 2024

Abstract
This paper discusses the applicability of a two-dimensional (2D) periodic pillar array as the first layer of an acoustic mirror for AlN-based solidly mounted resonators of bulk acoustic waves. It is based on the idea that the periodic pillar array behaves like a uniform layer when the period is much smaller than the wavelength and its behavior is given by the ensemble average of pillar materials. The simulation shows that the effective electromechanical coupling factor can be enhanced close to that of AlN-based film bulk acoustic resonators when the slot ratio is large. It is also shown that the use of a 2D pillar array can enhance the reflectivity of the Bragg reflector. It should be noted that the periodic 2D pillar array can also control the anisotropy of wave propagation along the surface. Owing to this, transverse mode resonances can be suppressed well by adjusting the wave dispersion curve properly.
Tensile-strained Ge1−x
Sn
x
layers on Si(001) substrate by solid-phase epitaxy featuring seed layer introduction
Authors: Hiraide Tatsuma , Shibayama Shigehisa , Kurosawa Masashi , Sakashita Mitsuo , Nakatsuka Osamu 
Published: March 2024

Abstract
Herein, we examined the seed layer-induced solid-phase epitaxy (SPE) of Ge1−x
Sn
x
layers on Si(001) substrate toward their in-plane strain control. We sequentially deposited crystallized Ge1−x
Sn
x
seed layers at 360 °C with thicknesses of 2 and 4 nm and amorphous Ge1−x
Sn
x
layers at 80 °C. First, it was found that the thicker Ge1−x
Sn
x
seed layer effectively promotes the Ge1−x
Sn
x
epitaxial growth, whereas polycrystalline Ge1−x
Sn
x
is likely to be formed for the no seed layer case. Then, we discussed the possible role of the seed layer in SPE promotion of the Ge1−x
Sn
x
layer on Si(001). Finally, we demonstrated that the in-plane strain ε in the SPE-Ge1−x
Sn
x
layer can be controlled by the annealing temperature according to the thermal expansion coefficient difference between the SPE-Ge1−x
Sn
x
layer and Si substrate. In this study, we succeeded in forming tensile-strained Ge and Ge1−x
Sn
x
layers on Si(001) substrate by 500 °C annealing; the ε values were 0.20% and 0.16%, respectively.
In-situ synthesis of CdS and Ag2S quantum dots in poly(diallyldimethylammonium chloride) gels
Authors: Taniguchi Shuto , Tsukuda Satoshi 
Published: March 2024

Abstract
In this study, we proposed a hybridization method for polymer and quantum dots (QDs) by directly forming QDs in polymer gel; this method was completely different from conventional methods such as mixing and encapsulation. QDs were fabricated by reacting metal ions in solution with sulfide ions adsorbed in a gel made from poly(diallyldimethylammonium chloride) (PDADMAC), a cationic polymer. CdS and Ag2S QDs were successfully fabricated in PDADMAC gel for in situ synthesis, and visible light (534 nm) and NIR (1070 nm) emissions were observed in PDADMAC gel containing CdS and Ag2S QDs, respectively. We also discussed the formation mechanism of QDs in the gel considering the mesh size of polymer networks in PDADMAC gel.
ІННОВАЦІЇ У ВІТЧИЗНЯНОМУ WELLNESS ТУРИЗМІ
Authors: Бабушко Світлана , Попович Сергій 
Published: March 2024

Статтю присвячено інноваціям у wellness туризмі. Для їх характеристики було проаналізовано діяльність і пропозиції вітчизняних санаторно-курортних закладів. Зясовано, що 70% закладів не орієнтовані на wellness туризм, а пропонують традиційні форми роботи з гостями. Зміни у діяльності решти оздоровчих закладів є інноваційними: впроваджуються нові технології, диверсифікуються послуги, формуються цікаві пропозиції оздоровлення, розширюються категорії гостей, створюються інноваційні програми оздоровлення з психологічними техніками, йогою, різними естетичними процедурами, спрямованими на догляд за тілом, та раціональним збалансованим харчуванням. Констатовано, що велнес туризм має гарні шанси на динамічний розвиток завдяки впровадженню інноваційних пропозицій для оздоровлення.
КОНЦЕПЦІЯ ОЦІНКИ ЗА СПРАВЕДЛИВОЮ ВАРТІСТЮ - ОСНОВНИЙ ПРИНЦИП ПІДГОТОВКИ ФІНАНСОВОЇ ЗВІТНОСТІ ЗА МСФЗ
Authors: Михалків Алла 
Published: March 2024

Розкрито сутність справедливої вартості з точки зору міжнародних стандартів фінансової звітності та стандартів оцінки. Досліджено виникнення та розвиток концепції справедливої вартості в бухгалтерському обліку . Розглянуто концепцію оцінки за справедливою вартістю як складової частини концепції звітності та обліку. Проаналізовано основні відмінності між концепцією історичної вартості та концепцією оцінки за справедливою вартістю. З'ясовано сучасні підходи до застосування концепції оцінки за справедливою вартістю.
РОЗПОДІЛ ВИТРАТ МАЙБУТНІХ ПЕРІОДІВ ЗА МЕТОДОМ НА ОСНОВІ ПОДАТКУ НА ПРИБУТОК ВІД ОПЕРАЦІЙНОЇ ДІЯЛЬНОСТІ
Authors: Сук Петро 
Published: March 2024

Розглянуто особливості відображення витрат майбутніх періодів в бухгалтерському обліку і фінансовій звітності.
Визначено можливість використання податку на прибуток від операційної діяльності як основи для розподілу витрат майбутніх періодів.
Доведено доцільність застосування методу на основі податку на прибуток від операційної діяльності для розподілу витрат майбутніх періодів.
Використання методу розподілу витрат майбутніх періодів на основі податку на прибуток від операційної діяльності розглянуто на прикладі.
Запропоновано два способи розрахунку методу розподілу витрат майбутніх періодів на основі податку на прибуток від операційної діяльності: 1) від початкової суми; 2) від залишкової суми.
SPECIFIC ASPECTS OF THE LEGAL AND REGULATORY FRAMEWORK FOR CYBERSECURITY IN DIFFERENT COUNTRIES OF THE WORLD IN THE CONTEXT OF THE INTERNATIONAL SECURITY SYSTEM
Authors: Horlichenko Serhii 
Published: March 2024

Cybersecurity is emerging as a critical issue in contemporary international law, with significant implications for the security of nations. The use of information and communication technologies poses potential threats to various aspects of societal and state functioning, prompting the international community to explore the establishment of a comprehensive legal framework for cooperative efforts in the area of cybersecurity.
The article describes the evolution of regulatory and legal mechanisms dedicated to securing cyberspace. The narrative emphasises that the establishment of rules governing activities in cyberspace requires careful consideration of cybersecurity, the protection of personal data, and the fight against cybercrime and cyberterrorism.
Looking to the future, the analysis of international legislation identifies areas for improvement in the area of cyberspace security under current conditions.
ВЕРИФІКАЦІЯ РОЗРАХУНКОВИХ МОДЕЛЕЙ ВИЗНАЧЕННЯМ АДЕКВАТНОСТІ ТА ТОЧНОСТІ
Authors: Нікулін Олександр , Наконечна Тетяна , Нікулін Олексій , Бяков Андрій 
Published: March 2024

Верифікацію розрахункових моделей процесу прокатування можна розглядати, як практичне оцінювання якості математичного моделювання процесів. Актуальна прикладна верифікація пов’язана з ефективністю інженерних рішень щодо вдосконалення виробничих процесів, яке спирається на адекватність і точність розрахунків. Для конкретизації методики розглянуті моделі визначення опору деформації сталі 45 при гарячій обробці тиском за підходами В.І. Зюзіна та інших, а також Андреюка-Тюленева. При оцінюванні адекватності та точності розрахунків використані аналітичні залежності, які також зручні для моделювання в системах проектування і керування технологією прокатування. На основі отриманих оцінок зроблено висновок про адекватність і припустиму точність розрахунків за формулами, тобто успішну верифікацію моделей.
ФАКТОРИ, ЯКІ ВПЛИВАЮТЬ НА РОБОТУ ТРАНСПОРТУ В ЗАЛЕЖНОСТІ ВІД ДОРОЖНІХ УМОВ
Authors: Давидчик Олександр , Коваленко Андрій , Коваленко Віталій 
Published: March 2024

Дослідження проводилися на ділянці автомобільної дороги Т0441 Кам'янське – Лобойківка Н31 – Петреківка – Царичанка Н31. Довжина маршруту – 54.3 км.
Розглянуті сучасні методи оцінки ефективності використання палива Основним вимірником паливної економічності автомобіля в нашій країні і в більшості європейських країн є витрата палива в літрах на 100 км пройденого шляху (шляхова витрата).
Проведена порівняльна лінійна залежність і логарифмічна. Із отриманих результатів, визначино що коефіцієнт кореляції кращий для логарифмічної залежності R=0.82 (для лінійної залежності R=0.7).
CULTURAL DIVERSITY IN NONVERBAL COMMUNICATION: COMPARING THE MEANING OF HUNGARIAN-RUSSIANAMERICAN NONVERBAL SIGNS
Authors: Toth Alexandra 
Published: March 2024

The aim of my research was to conduct a comparative analysis of nonverbal communication cues between Hungarian, Russian and American cultures, with a focus on the cultural specificities and overlaps of nonverbal cues used to express different emotions and states, such as aggressiveness, uncertainty and interest. The study involved an extensive literature review and a questionnaire survey with participants from different cultures to understand how these nonverbal signals are interpreted and perceived in different cultural contexts.
In the analysis, I paid particular attention to the different interpretations of body language, facial expressions, gestures and touch, and spatial relations cues. The results of the research have highlighted that although there are some common forms of nonverbal communication, there are also a number of significant cultural differences that fundamentally influence the encoding and decoding of messages.
For example, while in American culture direct eye contact and open posture can be signs of sincerity and confidence, in Hungarian and Russian cultures these signals can have different contexts and intensities. The meaning and acceptability of touch also varies; what is seen as a friendly gesture in one culture may suggest excessive closeness and inappropriateness in another.
The research also highlighted the intercultural communication difficulties and misunderstandings that can arise from different interpretations of nonverbal signals. This underlines the need to better understand and respect the communication customs and norms of different cultures in order to communicate effectively and efficiently.
At the end of my research, I have formulated recommendations for those involved in cross-cultural communication, whether in business, educational or personal contexts. I have stressed the importance of cultural sensitivity, avoiding prejudices and active listening, which can be key to successful and meaningful intercultural dialogues.
Evaluation of Cataract Surgery Outcomes in Geriatric Population with Geriatric Depression Scale
Authors: ÜNAL Gonca Ayşe , BARAK Ayşegül , GÜÇLÜ Emin Serbülent , ÖZER Ömer , BAYSAL Zeki 
Published: March 2024

Objective: The aim of this study was to show the changes in geriatric depression scale (GDS) scores in patients undergoing senile cataract surgery.
Methods: A total of 74 patients aged 60 years and older who underwent cataract surgery with phacoemulsification for senile cataract were included. All patients were evaluated with the GDS before cataract surgery and at the third month after surgery.
Results: The mean GDS in the preoperative period was 10.22 ± 5.01, while the mean GDS score in the postoperative period was 8.2 ± 4.92. There was a positive correlation (r=0.680 for preoperative and r=0.801 for postoperative) between visual acuity and GDS score in the preoperative period (p