bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metastatic papillary cancer of the neck: A diagnostic dilemma
Authors: Homan Mal R. , Gharib Hossein , Goellner John R. 
Published: February 2007

AbstractThe finding of papillary carcinoma in a neck mass usually leads to the presumptive diagnosis of metastatic thyroid carcinoma, with total thyroidectomy revealing the primary tumor. We report five cases of metastatic papillary carcinoma of the neck. The primary tumor in three of the cases was found to be nonthyroidal; two being discovered only after total thyroidectomy failed to reveal a primary cancer. In the two thyroidal neoplasms, pathologic examination of the thyroid demonstrated only minimal tumor in one case and no detectable tumor in the other. These cases illustrate the pitfalls of diagnosis and treatment of these tumors and the utility of antithyroglobulin immunostaining in such cases.
Computed tomography of primary subglottic cancer: Clinical importance of typical spread pattern
Authors: Saleh Ezzat M. , Mancuso Anthony A. , Alhussaini Ahmed A. 
Published: February 2007

AbstractThe spread pattern of 14 cases of primary subglottic cancer, as seen on computed tomography (CT), is analyzed. Cricoid cartilage invasion was present in nine cases. Tracheal invasion was definite in four cases and questionable in three. Extralaryngeal soft tissue spread was present in nine cases; all but one had cartilage destruction. The patterns of spread seen accurately reflect reports in previous whole‐organ section studies, and suggest that the elastic cone has a primary role in directing the spread of tumor.Anticipating spread to areas described above with CT and/or magnetic resonance imaging (MRI) can be used to try to improve treatment planning and perhaps outcome by: (1) avoiding placement of urgent tracheostomies close to the tumor; (2) helping to modify standard surgical approaches by suggesting lower‐than‐usual tracheostomies, or more extensive‐than‐usual thyroid gland resection; and (3) avoiding delay in diagnosis by strongly suggesting rebiopsy when imaging indicates a tumor is present, and initial endoscopy and biopsy cannot confirm the imaging findings.
Streptococcal gangrene of the head and neck: A case report and review of the literature
Authors: Miles L. Tracey , Jacobs Joseph B. , Gittelman Paul D. , Lebowitz Arthur S. 
Published: February 2007

AbstractNecrotizing bacterial infections that occur in the head and neck are exceedingly rare and are often associated with a group A beta‐hemolytic streptococcus (Streptococcus pyogenes). The disease is associated with soft tissue necrosis and vascular thrombosis. There appears to be an increasing incidence of hyperaggressive beta hemolytic streptococcal infections associated with high mortality rates. We report the survival of an otherwise healthy patient who developed a flu‐like illness followed by a rapidly progressive toxic systemic illness associated with subtotal facial soft tissue necrosis down to bone. The recent literature related to this necrotizing bacterial infection is reviewed. Otolaryngologists must be aware of this entity since survival depends upon aggressive early wound management and highdose intravenous antibiotics.
Value of grading squamous cell carcinoma of the head and neck
Authors: Roland Nicholas J. , Caslin Anthony W. , Nash John , Stell Philip M. 
Published: February 2007

AbstractWe report a series of 3,294 patients with squamous cell carcinoma of the head and neck seen by one of us between 1963 and 1990. Two thousand and seven patients had a histologically proven and graded, but previously untreated, squamous cell carcinoma of the mucosal surfaces of the head and neck. These tumors had been graded previously by many different pathologists in many different hospitals, both in the United Kingdom and the United States, as well as continental Europe, over this period. Of the host factors both sex and age were associated with differentiation: 34% of patients less than age 50 had a well‐differentiated tumor compared with 44% greater than age 50; 32% of women had a poorly differentiated tumor compared with 26% of men. General condition had no correlation with degree of differentiation. Site was closely associated with grading: well‐differentiated tumors were more common in the mouth and larynx and poorly differentiated tumors in the pharynx. Furthermore, of poorly differentiated tumors, 19% arose from areas normally lined by keratinized squamous epithelium, 22% from a nonkeratinized area, 36% from respiratory epithelium, and 45% from areas normally covered by lymphoid epithelium. T stage had no significant correlation with differentiation. However, 46% of patients with poorly differentiated tumors had a nodal metastasis at presentation compared with only 28% of well‐differentiated tumors. Distant metastases at presentation were found in 3.4% of poorly differentiated tumors compared with 1.8% of well‐differentiated tumors. The survival fell significantly from 33% for well‐differentiated tumors to 27% for poorly differentiated tumors. The recurrence rate at the primary site rose from 25% for well‐differentiated tumors to 27% for poorly differentiated tumors, and recurrence in the lymph nodes rose from 26% to 30%. Both differences were just significant.
Lymph node metastasis in squamous cell carcinoma of the oral cavity: Correlation between histologic features and the prevalence of metastasis
Authors: Umeda Masahiro , Yokoo Satoshi , Take Yoshiaki , Omori Akiteru , Nakanishi Koichi , Shimada Keikichi 
Published: February 2007

AbstractA retrospective study was made of the correlation between pre‐operative clinical or histologic findings and the prevalence of lymph node metastasis in 60 patients with squamous cell carcinoma of the oral cavity who had histologically confirmed neck metastasis. Of these 60 patients, 39 with clinically N+ necks underwent immediate therapeutic neck dissection, and 21 whose necks were initially NO but progressed to N+ during observation underwent subsequent therapeutic neck dissection. The primary site, TNM staging, histologic grade of malignancy of biopsy specimen, and location and number of histologically positive lymph nodes were reviewed in each case. The results were as follows:(1) The prevalence of neck metastasis was not significantly correlated with primary site and T stage; however, there was an apparent correlation between histologic grade of malignancy and the prevalence of neck metastasis. Patients with grade I‐II histologic malignancy showed limited metastases that involved lymph nodes in levels I‐II. On the other hand, patients showing grade III‐IV histologic malignancy often had metastases that extended beyond level III, regardless of T stage. These results suggest that histologic grade of malignancy, as well as clinical features, must be taken into consideration when deciding whether supraomohyoid neck dissection is indicated. (2) The group that underwent subsequent neck dissection exhibited less advanced neck metastasis and a better prognosis than the group which underwent immediat neck dissection. These findings show that if they are closely followed up, it is possible to delay neck dissection in NO patients until a neck metastasis is detected. © 1992 John Wiley & Sons, Inc.
Thyroid and parathyroid surgery without drains
Authors: Ruark Deborah S. , Abdel‐Misih Raafat Z. 
Published: February 2007

AbstractThe question of routine wound drainage after thyroid and parathyroid surgery remains controversial among experienced surgeons. Review of the literature failed to reveal any study that established the benefit of drainage after thyroidectomy and para‐thyroidectomy. A retrospective review of 139 thyroid or parathyroid procedures performed without drainage was conducted. One hundred ten thyroid operations were performed, including unilateral lobectomy with isthmusectomy [82 (74.5%)], total or bilateral subtotal thyroidectomy [26 (23.6%)], and isthmusectomy [2 (1.8%)]. Histologic examination yielded a benign diagnosis in 94 specimens (85.4%); 16 specimens (14.5%) contained thyroid carcinoma. Parathyroid explorations were performed in 29 patients (20.8%) all of whom had adenomas. Postoperatively, there were no instances of wound hematomas, infections, or rebleeding necessitating reoperation. Minor complications included asymptomatic wound seromas (4‐30 mL) in five (3.6%) patients, which were aspirated 2 weeks after discharge without further recurrence. This minimal complication rate of 3.6% with undrained neck incisions suggests that routine prophylactic drainage of thyroid and parathyroid wounds is unnecessary. © John Wiley & Sons.
Postoperative radioactive iodine evaluation of total thyroidectomy for thyroid carcinoma: Reappraisal and therapeutic implications
Authors: Attie Joseph N. , Bock George , Moskowitz Gerard W. , Margouleff Donald , Dubner Sanford 
Published: February 2007

AbstractThe records of 430 patients who underwent total thyroidectomy with radioactive iodine (RAI) uptake studies performed postop‐eratively were reviewed. Indications for the administration of an ablative dose of iodine 131 are given. The majority (85.4%) had no or low (less than 2%) evidence of focal uptake and therefore were not treated with ablative doses of iodine 131. RAI scanning is necessary postoperatively to determine the completeness of the surgical procedure and to detect residual or metastatic disease. Small foci of residual disease or occult distant metastases can be adequately treated with therapeutic doses of RAI. Nodal or distant metastases that become clinically evident following thyroidectomy are usually not successfully treated with RAI. © John Wiley & Sons, Inc.
Primary mucinous adenocarcinoma of the eyelid
Authors: Andrews Thomas M. , Gluckman Jack L. , Weiss Mark A. 
Published: February 2007

AbstractPrimary mucinous adenocarcinoma of the skin is a rare entity arising from eccrine sweat glands with a propensity for local recurrence and metastasis. This tumor has been widely reported in the ophthalmology literature, but not to our knowledge in the otolaryngology literature. A case of a 48‐year‐old man with a mucinous adenocarcinoma extensively involving the right eyelid and orbit necessitating craniofacial resection is presented together with a discussion of the pathology, clinical features, and management. © John Wiley & Sons, Inc.
Glandular odontogenic cyst
Authors: Van Heerden Willem F. P. , Raubenheimer Erich J. , Turner Martin L. 
Published: February 2007

AbstractTwo cases of glandular odontogenic cysts are reported. The unique histological features, eg, the intraepithelial glandular structure, papillary processes, and eosinophilic cuboidal and larger granular superficial cells are sufficient to warrant glandular odontogenic cyst as a distinct entity. Electron microscopic examination of the superficial eosinophilic cuboidal cells are suggestive of a process similar to apoptosis. Eroded cortical plates suggest an aggressive behavior.
Videofluoroscopy of the pharyngoesophageal segment during tracheoesophageal and esophageal speech
Authors: Isman Karin A. , O'Brien Christopher J. 
Published: February 2007

AbstractThe purpose of this preliminary investigation was to identify the location and length of the pharyngoesophageal (PE) segment during esophageal and tracheoesophageal (TE) speech among laryngectomees who were proficient in both methods of vocalization. Four patients who had undergone total laryngectomy and tracheoesophageal puncture served as subjects. Voice recordings were obtained and played to listeners of varying experience with laryngectomees. Videofluoroscopy was performed while the patients sustained “ah” in both modes of speech. Results of these analyses revealed that TE speech was rated as more effective than esophageal speech in all 4 subjects. However, only minimal differences were found in the length and the location of the PE segment during TE and esophageal speech when within subject comparisons were made. This study is the first to compare the physical characteristics of the PE segment during esophageal speech and TE speech as produced by the same speaker. © 1992 John Wiley & Sons, Inc.
Basaloid squamous carcinoma of the buccal cavity
Authors: Cadier Michael A. , Kelly Sarah A. , Parkhouse Nicholas , Brough Michael D. 
Published: February 2007

AbstractBasaloid‐squamous carcinoma was first recognized as a separate pathologic entity in 1986. It has been described in the hy‐popharynx, larynx, base of tongue, and nasal cavity. We report the first case of this rare tumor occurring in the buccal cavity and review the atypical squamous cell carcinomas that occurred in these sites. © 1992 John Wiley & Sons, Inc.
Curative irradiation of the entire orbit in rhabdomyosarcoma: A case report
Authors: Van Den Bogaert Walter , Van Limbergen Erik , Dralands Godelieve , Drochmans Alfons 
Published: February 2007

AbstractRhabdomyosarcoma (RMS) is a relatively frequent tumor in children. Judicious combinations have markedly improved treatment results in recent years. Orbital localizations are treated with chemotherapy and radiotherapy. It has been advocated that radiotherapy be limited to the original tumor bed. This case report illustrates the danger of shielding part of the orbit: in a clinically tumor‐free region before chemotherapy, which was shielded during radiotherapy, a local recurrence was seen while the original tumor bed remained controlled. Therefore, the whole content of the orbit should be irradiated in orbital RMS. © 1992 John Wiley & Sons, Inc.
Epithelial‐myoepithelial carcinoma of salivary gland with metastasis to lung: Report of a case and review of the literature
Authors: Noel Scott , Brozna John P. 
Published: February 2007

AbstractA 63‐year‐old man was initially seen with multiple pulmonary nodules 14 years after a left parotidectomy for an epithelial‐myoepithelial carcinoma of salivary gland. Eight and 18 months after parotidectomy, the patient had local recurrence of his salivary gland tumor. He remained disease‐free before being seen with pulmonary nodules, which were evaluated by open lung biopsy. The pathologic features of the pulmonary nodules were identical to the salivary gland tumor resected 14 years earlier. This is the fourth reported case of epithelial‐myoepithelial carcinoma of salivary gland metastasizing to a distant site. © 1992 John Wiley & Sons, Inc.
Basic science reviews: Tumor suppressor genes
Authors: Lee Norris K. 
Published: February 2007

AbstractTumor suppressor genes are negative regulators of cell growth. When their normal function is compromised, absence of their inhibitory effects can lead to unrestrained cell cycling and growth. Strong evidence now confirms that loss of proper function of these genes is a common occurrence leading to cancer. Their failure can be caused by alterations in the gene DNA or malfunction of their protein products. The recent extraordinary accumulation of knowledge about these genes reveals that normal carcinogenesis represents breakdown of normal regulatory processes. © 1992 John Wiley & Sons, Inc.
Metastatic thyroid cancer as an incidental finding during neck dissection: Significance and management
Authors: Vassilopoulou‐Sellin Rena , Weber Randal S. 
Published: February 2007

AbstractOccult thyroid cancer is an occasional incidental finding during surgery for other indications and is usually considered of minor clinical significance; however, the appropriate approach for incidentally found metastatic thyroid cancer is less clear especially when it occurs in the context of another malignancy that has more aggressive potential. Among 2,855 patients treated for squamous cancer of the tongue at The University of Texas M. D. Anderson Cancer Center, eight patients had coexisting differentiated thyroid cancer metastatic to cervical lymph nodes which was found incidentally during regional lymph node dissection. The eight patients included three women and five men with a median age of 47 years (range, 32‐62 years); tumors were of the papillary variety in four patients and follicular in the other four. In one patient, no gross or microscopic primary tumor could be identified after thyroidectomy; in another patient, no gross tumor was evident, but whole organ section revealed an area of fibrosis consistent with a primary lesion. Two patients had primary lesions less than 1 cm in maximal diameter. In four patients who had no surgery, physical exam and radiologic evaluation failed to show any intrathyroidal lesions. Clinically relevant thyroid cancer did not develop in any of those patients during the duration of documented follow‐up (1‐15 years). Three patients died of progressive tongue cancer, one patient of unrelated pulmonary disease, and four patients remain alive without evidence of disease for 1 to 15 years of available follow‐up. We suggest that differentied thyroid cancer discovered incidentally during surgery for another, potentially more aggressive mallignancy may be approached conservatively when the thyroid gland does not demonstrate clinical or radiologic lesions. © 1992 John Wiley & Sons Inc.
Double skin island pectoralis major myocutaneous flap with nipple‐areola complex preservation: A case report
Authors: Espinosa Manuel H. , Phillip John A. , Khatri Vijay P. , Amin Atul K. 
Published: February 2007

AbstractA horizontal double skin island pectoralis major myocutaneous flap with preservation of nipple‐areola complex is described, a different modification used to reconstruct a complex defect following radical resection of a locally advanced gingival carcinoma. The skin islands are horizontally separated by a distance of 2.5 cm but rely on one vascular pedicle for their blood supply. The muscle between the skin islands provides the soft tissue bulk between the internal mucosal and external skin lining. The need for a separate segmental flap or a split‐thickness skin graft for mucosal lining was eliminated. © 1992 John Wiley & Sons, Inc.
Spontaneous rupture of the common carotid artery: A case report
Authors: Kim Kwang Hyun , Sung Myung Whun , Oh Seung Ha 
Published: February 2007

AbstractSpontaneous rupture of the common carotid artery is an extremely rare vascular disorder in the head and neck region. Pseudoaneurysm can be formed by arterial rupture, presenting clinically as an expanding mass lesion. A 37‐year‐old fisherman suffered from the spontaneous rupture of the left common carotid artery and resultant pseudoaneurysm was radiologically recognized. Surgical exploration revealed a 0.5‐cm rent in the common carotid artery, 2 cm proximal to the bifurcation. The lesion was successfully managed with polypropylene sutures during temporary clamping of the carotid artery. The literature is reviewed and the principles of management are discussed. © 1992 John Wiley & Sons, Inc.
Dentascan imaging of the mandible and maxilla
Authors: Yanagisawa Ken , Friedman Craig D. , Vining Eugenia M. , Abrahams James J. 
Published: February 2007

AbstractDentaScan is a unique new computer software program which provides computed tomographic (CT) imaging of the mandible and maxilla in three planes of reference: axial, panoramic, and oblique sagittal (or cross‐sectional). The clarity and identical scale between the various views permits uniformity of measurements and cross‐referencing of anatomic structures through all three planes. Unlike previous imaging techniques, the oblique sagittal view permits the evaluation of distinct buccal and lingual cortical bone margins, as well as clear visualization of internal structures, such as the incisive and inferior alveolar canals. Several case reports are presented to demonstrate the clinical usefulness of DentaScan.
Simultaneous chemoradiotherapy as salvage treatment in locoregional recurrences of squamous head and neck cancer
Authors: Gandia Daniel , Wibault Pierre , Guillot Thierry , Bensmaine Amine , Armand Jean P. , Marandas Patrick , Luboinski Bernard , Cvitkovic Esteban 
Published: February 2007

AbstractThis study was designed to determine if long‐term palliation could be obtained in pre‐irradiated locoregional recurrent squamous head and neck cancer patients, with the administration of simultaneous chemoradiotherapy. Mandatory eligibility criteria were histologically documented squamous head and neck cancer in previously irradiated territory, surgical or brachytherapy salvage unfeasibility, or patient refusal. The protocol consisted of radiotherapy, at a rate of 5 daily fractions of 2 Gy on altermate weeks, with simultaneous continuous intravenous infusion of 5‐fluorouracil (5FU) at 800 mg/m2 and oral hydroxyurea (HU) at 1.000–1,500 mg/day for 5 days. Tolerance was good. Acute toxicity was low with no grade ‐⩾ III WHO hematologic toxicity observed. Nine patients had grade III mucositis, one had grade IV, three had grade III skin toxicity, and only four patients required a 20% to 30% 5FU dose reduction because of it. Two patients had hand and foot syndrome, and two had asymptomatic 5FU‐related cardiac signs (1 ECG, 1 echographic + ECG). Chronic radiotherapy‐related effects consisted of Her mitte's sign observed in two patients. Of 34 registered patients, 33 were evaluable for response. An overall rate of 55% (18 patients) of objective responses [complete response (CR) + partial response (PR)] was obtained, with 12 patients (36%) achieving local control of disease. The median survival was 11 months. These data show that palliation could be obtained for the majority of responding patients, and also suggest an improvement in the immediate prognosis with this type of salvage procedure for a selected group of recurrent squamous head and neck cancer patients.
Association of hyperparathyroidism with nonmedullary thyroid carcinoma: Review of 31 cases
Authors: Attie Joseph N. , Vardhan Reddy 
Published: February 2007

AbstractIn a series of 948 patients operated on for primary hyperparathyroidism (HPT) by one surgeon (JNA) from 1952 to 1992, there were 242 (26%) instances of coincidental thyroid and parathyroid disease. Of these, 211 had benign thyroid lesions. In the remaining 31 cases HPT was associated with nonmedullary thyroid carcinoma; all were treated by resection of parathyroid adenomas and thyroidectomy. One patient died of unrelated cause (carcinoma of breast) 11 years following surgery. The remaining 30 patients are living and well 2 to 20 (mean 8.2 years) years after surgery; there was no recurrence or thyroid cancerrelated mortality in the series. In contrast to prior reports, only six (20%) of our patients had a history of prior radiotherapy. We suggest that during neck exploration for HPT, the entire thyroid gland be evaluated and all palpable nodules resected and submitted to pathologic study.
Local control of squamous cell carcinoma following marginal and segmental mandibulectomy
Authors: Dubner Sanford , Heller Keith S. 
Published: February 2007

AbstractThe records of 130 consecutive patients undergoing marginal or segmental mandibulectomy for squamous cell carcinoma of the oral cavity or oropharynx were reviewed. An attempt was made to correlate incidence of recurrence with characteristics of the primary tumor and extent of mandibulectomy. The local recurrence rate was 19% following marginal mandibulectomy and 6% following segmental mandibulectomy. The incidence of local recurrence was independent of the size of the primary tumor or the extent of lymph node metastases. Neither mandibular invasion by tumor nor the addition of radiotherapy influenced local recurrence. Ten of 15 patients recurring locally after marginal mandibulectomy were salvaged by further surgery. This study suggests that local control following marginal mandibulectomy is comparable to that following segmental mandibulectomy regardless of the size of the tumor. Segmental mandibulectomy should be reserved for those tumors invading deeply into the mandible or wrapping around it.