bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Relocation of Villagers into Public Housing: Some Suggestive Findings from a Singaporean Stud*1
Authors: Spiro Shimon E. 
Published: June 2008

AbstractThe relocation of villagers into modern high-rise housing estates is, in most countries, the exception rather than the rule. The urbanization of rural populations is, more typically, a gradual process. Rural migrants first settle in inner-city slums and squatter areas of the urban fringe, where they are often able to maintain some of the living arrangements and patterns of social organization which are characteristically rural Only after additional movements within these areas of first settlement, and after sufficient time had elapsed to allow for some assimilation into urban life, will some of the migrants, or their descendants, move into high rise public housing estates. This form of housing is, in many respects, the ultimate in urban living. It is characterized by nuclear families, occupying rigidly defined space, living among strangers, and subject to bureaucratic rules and controls. However, the fact that families typically move to housing estates after having experienced some form of urban living may ease the transition. Also, the fact that slum dwellings are often of physically inferior quality compared to estate housing3 may increase the willingness of new residents to accept some of the constraints of estate living.
A Projection for Labour Demand and Supply in Singapore to 1985
Authors: Ker S.T. 
Published: June 2008

AbstractThe purpose of this paper is to project the demand for labour in various sectors of the Singapore economy to 1985. The supply of labour will also be forecast and compared with labour demand. A labour demand equation will be specified and tested by the data of the period 1960-1974. Part I will discuss the specification of the model and data collection. Part II reports the regression results and Part III provides a projection based on average growth rate of variables in the labour demand equation. The final part compares the projected labour demand and labour supply for the period 1975-1985. Observations will be derived and implications discussed in the same section.
Fetal Pig:The High School Dissection Experience
Authors: Barr Gracia , Herzogl Harold 
Published: June 2008

AbstractUsing qualitative methods, we observed a series of fetal pig dissection sessions in a high school biology course and interviewed 17 students in the class.The students' responses to dissection varied considerably. Most felt that dissection was a positive experience, but a substantial minority viewed it primarily in negative terms. Almost all the students had some ambivalence about aspects of the fetal pig lab and believed that alternatives should be provided for students who object to the practice. We argue that dissection remains a viable educational tool but should be an optional rather than compulsory component of the curriculum.
English Almanacs and Animal Health Care in the Seventeenth Century
Authors: Hill Curthl Louise 
Published: June 2008

AbstractIn seventeenth-century England, the health and welfare of nonhuman animals rested almost solely on the shoulders of their keepers. Veterinary institutions had not yet been founded, and academically trained animal doctors did not exist. Laymen, however, had access to a great deal of information on animal health care. A range of printed publications were available that offered medical advice.The most accessible and easily understood were the ubiquitous almanacs. This article will examine the type of medical guidance offered in these cheap, annually-produced reference books. The major focus was on preventative practices because it was recognized that it was far easier to maintain a state of health than to cure illnesses. When such efforts failed, readers could also obtain recipes for remedies and treatments in almanacs.
Animals in Psychology Education and Student Choice
Authors: Cunninghaml Paul F. 
Published: June 2008

AbstractThis article identifies some of the important issues that underlie student-teacher conflicts regarding animal experimentation and dissection in psychology education. Understanding the reasons why students object to animal laboratories, why some teachers may refuse students access to non-animal alternatives, and why other teachers support student choice is an important first step in resolving student-teacher disputes regarding the use of animals in the psychology classroom.The article discusses why establishing an openly declared student choice policy at schools that use animals in psychology education is a reasonable thing to do and describes how a student choice policy works in practice.
Three Transgressions: Nietzsche, Heidegger, Derrida
Authors: Caputo John D. 
Published: June 2008

AbstractNietzsche, Heidegger and Derrida: these are not merely the names of three authors, but of three matters for thought, of three ways beyond metaphysics, three transgressions. I want to offer here a reflection, first, upon the dynamics of these transgressions—how each conceives metaphysics and where each makes its move against metaphysics—and, then, upon the relationships of the three to one another, on the interplay of their transgressive practices.
Automatic Designation of the Melting Layer with a Polarimetric Prototype of the WSR-88D Radar
Authors: Giangrande Scott E. , Krause John M. , Ryzhkov Alexander V. 
Published: June 2008

Abstract
A new polarimetric melting layer detection algorithm (MLDA) is utilized to estimate the top (melting level) and bottom boundaries of the melting layer and is tailored for operational deployment. Melting layer designations from a polarimetric prototype of the Weather Surveillance Radar-1988 Doppler (WSR-88D) in central Oklahoma are validated using radiosonde and model temperature analysis. It is demonstrated that the MLDA estimates the top of the melting layer with a root-mean-square error of about 200 m within 60 km of the radar. There is evidence that the polarimetric radar might yield better spatial and temporal designation of the melting layer within the storm than that obtained from existing numerical model output and soundings.
A Midlatitude Precipitating Cloud Database Validated with Satellite Observations
Authors: Chaboureau Jean-Pierre , Söhne Nathalie , Pinty Jean-Pierre , Meirold-Mautner Ingo , Defer Eric , Prigent Catherine , Pardo Juan R. , Mech Mario , Crewell Susanne 
Published: June 2008

Abstract
The simulations of five midlatitude precipitating events by the nonhydrostatic mesoscale model Méso-NH are analyzed. These cases cover contrasted precipitation situations from 30° to 60°N, which are typical of midlatitudes. They include a frontal case with light precipitation over the Rhine River area (10 February 2000), a long-lasting precipitation event at Hoek van Holland, Netherlands (19 September 2001), a moderate rain case over the Elbe (12 August 2002), an intense rain case over Algiers (10 November 2001), and the “millennium storm” in the United Kingdom (30 October 2000). The physically consistent hydrometeor and thermodynamic outputs are used to generate a database for cloud and precipitation retrievals. The hydrometeor vertical profiles that were generated vary mostly with the 0°C isotherm, located between 1 and 3 km in height depending on the case. The characteristics of this midlatitude database are complementary to the GPROF database, which mostly concentrates on tropical situations. The realism of the simulations is evaluated against satellite observations by comparing synthetic brightness temperatures (BTs) with Advanced Microwave Sounding Unit (AMSU), Special Sensor Microwave Imager (SSM/I), and Meteosat observations. The good reproduction of the BT distributions by the model is exploited by calculating categorical scores for verification purposes. The comparison with 3-hourly Meteosat observations demonstrates the ability of the model to forecast the time evolution of the cloud cover, the latter being better predicted for the stratiform cases than for others. The comparison with AMSU-B measurements shows the skill of the model to predict rainfall at the correct location.
The Effect of Irrigation on Regional Temperatures: A Spatial and Temporal Analysis of Trends in California, 1934–2002
Authors: Lobell David B. , Bonfils Céline 
Published: June 2008

AbstractThe response of air temperatures to widespread irrigation may represent an important component of past and/or future regional climate changes. The quantitative impact of irrigation on daily minimum and maximum temperatures (Tmin and Tmax) in California was estimated using historical time series of county irrigated areas from agricultural censuses and daily climate observations from the U.S. Historical Climatology Network. Regression analysis of temperature and irrigation changes for stations within irrigated areas revealed a highly significant (p &lt; 0.01) effect of irrigation on June–August average Tmax, with no significant effects on Tmin (p &gt; 0.3). The mean estimate for Tmax was a substantial 5.0°C cooling for 100% irrigation cover, with a 95% confidence interval of 2.0°–7.9°C. As a result of small changes in Tmin compared to Tmax, the diurnal temperature range (DTR) decreased significantly in both spring and summer months. Effects on percentiles of Tmax within summer months were not statistically distinguishable, suggesting that irrigation’s impact is similar on warm and cool days in California. Finally, average trends for stations within irrigated areas were compared to those from nonirrigated stations to evaluate the robustness of conclusions from previous studies based on pairwise comparisons of irrigated and nonirrigated sites. Stronger negative Tmax trends in irrigated sites were consistent with the inferred effects of irrigation on Tmax. However, Tmin trends were significantly more positive for nonirrigated sites despite the apparent lack of effects of irrigation on Tmin from the analysis within irrigated sites. Together with evidence of increases in urban areas near nonirrigated sites, this finding indicates an important effect of urbanization on Tmin in California that had previously been attributed to irrigation. The results therefore demonstrate that simple pairwise comparisons between stations in a complex region such as California can lead to misinterpretation of historical climate trends and the effects of land use changes.
A Revised U.S. Climate Extremes Index
Authors: Gleason Karin L. , Lawrimore Jay H. , Levinson David H. , Karl Thomas R. , Karoly David J. 
Published: June 2008

Abstract
A revised framework is presented that quantifies observed changes in the climate of the contiguous United States through analysis of a revised version of the U.S. Climate Extremes Index (CEI). The CEI is based on a set of climate extremes indicators that measure the fraction of the area of the United States experiencing extremes in monthly mean surface temperature, daily precipitation, and drought (or moisture surplus). In the revised CEI, auxiliary station data, including recently digitized pre-1948 data, are incorporated to extend it further back in time and to improve spatial coverage. The revised CEI is updated for the period from 1910 to the present in near–real time and is calculated for eight separate seasons, or periods.
Results for the annual revised CEI are similar to those from the original CEI. Observations over the past decade continue to support the finding that the area experiencing much above-normal maximum and minimum temperatures in recent years has been on the rise, with infrequent occurrence of much below- normal mean maximum and minimum temperatures. Conversely, extremes in much below-normal mean maximum and minimum temperatures indicate a decline from about 1910 to 1930. An increasing trend in the area experiencing much above-normal proportion of heavy daily precipitation is observed from about 1950 to the present. A period with a much greater-than-normal number of days without precipitation is also noted from about 1910 to the mid-1930s. Warm extremes in mean maximum and minimum temperature observed during the summer and warm seasons show a more pronounced increasing trend since the mid-1970s. Results from the winter season show large variability in extremes and little evidence of a trend. The cold season CEI indicates an increase in extremes since the early 1970s yet has large multidecadal variability.
Warming Trend of the Indian Ocean SST and Indian Ocean Dipole from 1880 to 2004*
Authors: Ihara Chie , Kushnir Yochanan , Cane Mark A. 
Published: June 2008

AbstractThe state of the Indian Ocean dipole representing the SST anomaly difference between the western and southeastern regions of the ocean is investigated using historical SST reconstructions from 1880 to 2004. First, the western and eastern poles of the SST-based dipole mode index are analyzed separately. Both the western and eastern poles display warming trends over this period, particularly after the 1950s. The western pole tends to be anomalously colder than the eastern pole from 1880 to 1919, whereas in the interval 1950–2004 the SST anomalies over the western pole are comparable to those over the eastern pole though there are occasional outliers where the eastern pole is anomalously colder than the western pole.The tendencies of the occurrences of positive and negative dipole events in September–November show three distinct regimes during the period analyzed. In 1880–1919, negative dipole events associated with La Niña events occur more frequently than positive events. In 1920–49, some weak positive events occur relatively independently of El Niño events over the Pacific. The period of 1960–2004 is characterized by strong and frequent occurrences of positive events associated with El Niño events.
Childhood systemic lupus erythematosus in Latin America. The GLADEL experience in 230 children
Authors: Ramírez Gómez LA , Uribe Uribe O , Osio Uribe O , Grisales Romero H , Cardiel MH , Wojdyla D , Pons-Estel BA ,   on behalf of the Grupo Latinoamericano de Estudio del Lupus (GLADEL)
Published: June 2008

Abstract To evaluate disease characteristics of childhood onset SLE in Latin America and to compare this information with an adult population in the same cohort of GLADEL. A protocol was designed as a multicenter, multinational, inception cohort of lupus patients to evaluate demographic, clinical, laboratory and serological variables, as well as classification criteria, disease activity, organ damage and mortality. Descriptive statistics, chi square, Fisher's exact test, Student's t test and multiple logistic regression were used to compare childhood and adult onset SLE. 230 patients were < 18 years and 884 were adult SLE patients. Malar rash, fever, oral ulcers, thrombocytopenia and hemolytic anemia and some neurologic manifestations were more prevalent in children (p < 0.05). On the other hand, myalgias, Sjögren’s syndrome and cranial nerve involvement were more frequently seen in adults (p < 0.05). Afro-Latin-American children had a higher prevalence of fever, thrombocytopenia and hemolytic anemia. White and mestizo children had a higher prevalence of malar rash. Mestizo children had a higher prevalence of cerebrovascular disease and cranial nerve involvement. Children met SLE ACR criteria earlier with higher mean values than adults (p: 0.001). They also had higher disease activity scores (p: 0.01), whereas adults had greater disease damage (p: 0.02). In Latin America, childhood onset SLE seems to be a more severe disease than adults. Some differences can be detected among ethnic groups.
Comparative study of four different assays for the detection of binding antibodies against interferon-β
Authors: Gneiss C , Brugger M , Millonig A , Fogdell-Hahn A , Rudzki D , Hillert J , Berger T , Reindl M , Deisenhammer F 
Published: June 2008

Background Binding antibodies (BAB) against interferon-β (IFNβ) are often determined as screening assays before performing an expensive and elaborate neutralizing antibody (NAB) test. Methods In this study, we compared four BAB tests, a western blot (WB), a direct binding enzyme-linked immunosorbent assay (ELISA) (dELISA), a capture ELISA (cELISA), and a commercial enzyme immuno-assay (EIA) in 325 multiple sclerosis patients with and without neutralizing antibodies to evaluate the sensitivity and specificity to detect NAB by receiver operating characteristics analysis. Results The area under the curve (AUC) values were 0.907 for the dELISA, 0.925 for the cELISA, and 0.776 for the EIA ( P < 0.0001 for all). At a sensitivity of 95%, the specificity was approximately 30% in the dELISA, 55% in the cELISA, and 13% in the EIA. The WB as a qualitative BAB detection method had a given sensitivity of 97% and a specificity of 55%. There was a strong and significant correlation between high NAB titers (>500 neutralizing units [NU]) and titers obtained by all quantitative BAB assays. However, low to medium NAB titers (20–500 NU) did not significantly correlate with BAB titers. Conclusion We conclude that the cELISA seems to be most suitable for NAB screening, but BAB titers cannot reliably predict NAB titers.
Review: Stem cell therapy: the great promise in lung disease
Authors: Siniscalco Dario , Sullo Nikol , Maione Sabatino , Rossi Francesco , D'Agostino Bruno 
Published: June 2008

Lung injuries are leading causes of morbidity and mortality worldwide. Pulmonary diseases such as asthma or chronic obstructive pulmonary disease characterized by loss of lung elasticity, small airway tethers, and luminal obstruction with inflammatory mucoid secretions, or idiopathic pulmonary fibrosis characterized by excessive matrix deposition and destruction of the normal lung architecture, have essentially symptomatic treatments and their management is costly to the health care system. Regeneration of tissue by stem cells from endogenous, exogenous, and even genetically modified cells is a promising novel therapy. The use of adult stem cells to help with lung regeneration and repair could be a newer technology in clinical and regenerative medicine. In fact, different studies have shown that bone marrow progenitor cells contribute to repair and remodeling of lung in animal models of progressive pulmonary hypertension. Therefore, lung stem cell biology may provide novel approaches to therapy and could represent a great promise for the future of molecular medicine. In fact, several diseases can be slowed or even blocked by stem cell transplantation.
Paroxysmal nocturnal hemoglobinuria: natural history of disease subcategories
Authors: de Latour Régis Peffault , Mary Jean Yves , Salanoubat Célia , Terriou Louis , Etienne Gabriel , Mohty Mohamad , Roth Sophie , de Guibert Sophie , Maury Sebastien , Cahn Jean Yves , Socié Gerard 
Published: June 2008

AbstractThe natural history of paroxysmal nocturnal hemoglobinuria (PNH) clinical subcategories (classic PNH and aplastic anemia [AA]/PNH syndrome) is still unknown. We retrospectively studied 460 PNH patients diagnosed in 58 French hematologic centers from 1950 to 2005. The median (SE) follow-up time was 6.8 (0.5) years. The median survival time (SE) was 22 (2.5) years. We identified 113 patients with classic PNH, 224 patients with AA-PNH syndrome, and 93 (22%) intermediate patients who did not fit within these 2 categories. At presentation, classic PNH patients were older, with more frequent abdominal pain and displayed higher levels of GPI-AP–deficient granulocytes. A time-dependent improved survival was observed. In classic PNH, diagnoses before 1986 (hazard ratio [HR]: 3.6; P = .01) and increasing age (P < .001) were associated with worse survival prognoses, whereas use of androgens within the first year after diagnosis was protective (HR, 0.17; P = .01). Transfusions before 1996 (HR, 2.7; P = .007) led to lower survival rates in patients with AA-PNH syndrome, whereas immunosuppressive treatment was associated with better outcomes (HR, 0.33; P = .03). Evolution to thrombosis affected survival in both subcategories (classic PNH: HR, 7.8 [P < .001]; AA-PNH syndrome: HR, 33.0 [P < .001]). Evolution to bicytopenia or pancytopenia for classic PNH (HR, 7.3, P < .001) and malignancies for AA-PNH syndrome (HR, 48.8; P < .001) were associated with worse outcomes. Although clinical presenta-tion and prognosis factors are different, classic PNH and AA-PNH syndrome present roughly similar outcomes, affected mainly by complications.
Depletion of human regulatory T cells specifically enhances antigen-specific immune responses to cancer vaccines
Authors: Morse Michael A. , Hobeika Amy C. , Osada Takuya , Serra Delila , Niedzwiecki Donna , Lyerly H. Kim , Clay Timothy M. 
Published: June 2008

Abstract
CD4+CD25highFoxP3+ regulatory T (Treg) cells limit antigen-specific immune responses and are a cause of suppressed anticancer immunity. In preclinical and clinical studies, we assessed the immune consequences of FoxP3+ Treg-cell depletion in patients with advanced malignancies. We demonstrated that a CD25high targeting immunotoxin (denileukin diftitox) depleted FoxP3+ Treg cells, decreased Treg-cell function, and enhanced antigen-specific T-cell responses in vitro. We then attempted to enhance antitumor immune responses in patients with carcinoembryonic antigen (CEA)–expressing malignancies by Treg-cell depletion. In a pilot study (n = 15), denileukin diftitox, given as a single dose or repeated dosing, was followed by immunizations with dendritic cells modified with the fowlpox vector rF-CEA(6D)-TRICOM. By flow cytometric analysis, we report the first direct evidence that circulating CD4+CD25highFoxP3+ Treg cells are depleted after multiple doses of denileukin diftitox. Earlier induction of, and overall greater exposure to, the T-cell response to CEA was observed in the multiple-dose group, but not the single-dose group. These results indicate the potential for combining Treg-cell depletion with anticancer vaccines to enhance tumor antigen-specific immune responses and the need to explore dose and schedule of Treg depletion strategies in optimiz-ing vaccine efforts. This trial was registered at www.clinicaltrials.gov as no. NCT00128622.
A unique three-dimensional model for evaluating the impact of therapy on multiple myeloma
Authors: Kirshner Julia , Thulien Kyle J. , Martin Lorri D. , Debes Marun Carina , Reiman Tony , Belch Andrew R. , Pilarski Linda M. 
Published: June 2008

AbstractAlthough the in vitro expansion of the multiple myeloma (MM) clone has been unsuccessful, in a novel three-dimensional (3-D) culture model of reconstructed bone marrow (BM, n = 48) and mobilized blood autografts (n = 14) presented here, the entire MM clone proliferates and undergoes up to 17-fold expansion of malignant cells harboring the clonotypic IgH VDJ and characteristic chromosomal rearrangements. In this system, MM clone expands in a reconstructed microenvironment that is ideally suited for testing specificity of anti-MM therapeutics. In the 3-D model, melphalan and bortezomib had distinct targets, with melphalan targeting the hematopoietic, but not stromal com-partment. Bortezomib targeted only CD138+CD56+ MM plasma cells. The localization of nonproliferating cells to the reconstructed endosteum, in contact with N-cadherin–positive stroma, suggested the presence of MM-cancer stem cells. These drug-resistant CD20+ cells were enriched more than 10-fold by melphalan treatment, exhibited self-renewal, and generated clonotypic B and plasma cell progeny in colony forming unit assays. This is the first molecularly verified demonstration of proliferation in vitro by ex vivo MM cells. The 3-D culture provides a novel biologically relevant preclinical model for evaluating therapeutic vulnerabilities of all compartments of the MM clone, including presumptive drug-resistant MM stem cells.