bluuebunny/crossref_metadata_2025_split huggingface dataset:
Management of cervical dystonia through Ayurveda - A case report
Authors: Prarthana T. 
Published: March 2024

Abstract
Spasmodic torticollis is a rare condition characterized by involuntary movement of the head. The pain often becomes the primary reason for the patient to seek medical attention, with the patient almost indifferent to the dystonic movements. Prakupita Vata (aggravated Vata) causes various kinds of diseases of Vata called Vata Vyadhi (diseases of vitiated Vata) and treatments such as Snehana (oleation therapy), Swedana (sudation therapy), and Shodhana (internal detoxification) are advised. The patient complaining of pain, stiffness of the neck, and tremors gradually progressing to hyperextension of the neck was clinically diagnosed as Dhatu Kshaya Vata Vikara and treated on the lines of Vata Vyadhi (diseases of vitiated Vata). Shodhana (internal detoxification) such as Nasya and Basti, in combination with external Panchakarma procedures and internal medicines including Rasayana (rejuvenation), were administered. Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) was assessed for the outcome of the treatment. The patient showed good improvement in pain, stiffness, tremors, and neck retention time. TWSTRS score had reduced from 66.25 to 29 and is presented here as a case study.
Patterns of smoking among oncologists of Eastern India
Authors: Chatterjee Koushik , Ray Amitabh , Chakraborty Arup 
Published: March 2024

Background:
Oncologists deal with smoking-related cancers in their daily practice, and eastern India is known to be the smoking capital of India.

Objective:
This study was aimed at evaluating the pattern and practice of smoking among oncologists of eastern India.

Materials and Methods:
This was a questionnaire-based observational study conducted from April 2017 to May 2017 at the Institute of Postgraduate Medical Education and Research in Kolkata, India. Oncologists from West Bengal were eligible to participate through a predesigned questionnaire. The questionnaire was administered to the participants through e-mail to assess the smoking pattern. The responses were received by an independent reviewer and forwarded to the investigators in a de-identified form. The data were analyzed by the investigators using simple descriptive statistical methods.

Results:
Out of 262 oncologists who were e-mailed the questionnaire, valid responses were received from a total of 132 (50.4%) oncologists, of which 130 (98.4%) were male and 2 (1.6%) were female. The median age of the respondents was 48 years (range, 28-72). Of these, 50 (38%) respondents were ever-smokers and 82 (62%) were never-smokers. Out of the ever-smokers (n = 50), 23 (46%) were moderate to heavy smokers; 14 (28%) were heavy smokers; 42 (84%) were current smokers; and 31 (74%) smoked daily. The median age of smoking onset was 19 years (range, 12–29), and the median duration of smoking was 78 months (range, 2-480). Peer pressure was the most common reason for smoking initiation, reported by 55% of the respondents, followed by adventure in 33%. Out of the total 76 smokers in the ever- and never-smoker groups, 43 (56.5%) attempted to quit for a median of 2 times (range, 1-6). There were 30 (69.7%) successful quitters in the group. Health concern was the most common reason to quit, whereas mental stress was the most common cause of relapse.

Conclusion:
Our study suggests that an alarmingly large number of oncologists from West Bengal are smokers, with the majority of them smoking daily at moderate to heavy levels.
Fatigue in patients with head-and-neck malignancies receiving radiation therapy and impact on quality of life: A prospective observational study
Authors: Moosa Zaiba , Kapoor Ankita R. , Chandra Manish , Bhalavat Rajendra , Pareek Vibhay , Srivastava Amrita , Nandakumar P , Bauskar Pratibha , Shincy N. V , Kapoor Akhil 
Published: March 2024

ABSTRACT

Background:
Cancer-related fatigue is an important but often unrecognized problem in patients with head-and-neck cancer undergoing radiation therapy.

Objectives:
To assess cancer-related fatigue in patients with head-and-neck cancer undergoing radiation therapy, and to evaluate for any impact on the quality of life (QoL).

Materials and Methods:
Between Oct 2015 and Dec 2016, we included 120 patients with head-and-neck cancers, who were treated with definitive or post-operative radiotherapy using intensity-modulated radiation therapy (IMRT) or 3-dimensional conformal radiation therapy (3DCRT), with or without concurrent chemotherapy. Fatigue was assessed with the Brief Fatigue Inventory (BFI) questionnaire and the impact of cancer-related fatigue on QoL was assessed by the European Organization for Research and Treatment of Cancer (EORTC) questionnaires (QLQ-C30) and Head and Neck (H&N) 35; these questionnaires were filled at the start, completion, and in the third month after treatment. Based on the BFI score, fatigue was graded as mild (1–3), moderate (4–7), or severe (8–10). A score of 4 or higher on the BFI was considered an indication for some form of intervention.

Results:
The mean fatigue score before the start of radiation was 2.43; at the completion of treatment, the fatigue score increased to 5.07, and then decreased to 0.53 by the third month of follow-up (P < 0.0001). There was an increase in the score on the EORTC QLQ-H&N35 indicating worsening QoL at the completion of treatment as compared to that before the start of treatment with a subsequent decline in all the scores, except dryness of the mouth, by the third month of follow up. There was an increase in the score for dryness of the mouth from the completion of treatment to the third month of follow-up.

Conclusion:
Patients undergoing chemoradiation for head-and-neck cancers suffer worsening fatigue at the time of completion of treatment which impacts the QoL, but subsequently improves with time.
Effect of ADME gene polymorphisms on pemetrexed pharmacokinetics in patients with non-small-cell lung cancer: A prospective study
Authors: Kumar Sharath , Shriyan Bharati , Patil Anand , Yadav Snehal , Jadhav Shraddha , Asar Mashfa , Krishnamurthy Manjunath Nookala , Patil Vijay , Joshi Amit , Noronha Vanita , Prabhash Kumar , Gota Vikram 
Published: March 2024

ABSTRACT

Background:
Pemetrexed is an approved first-line treatment for advanced non-squamous, non-small-cell lung cancer (NSCLC). The pharmacokinetics of pemetrexed is highly variable. Evidence of altered clinical response and toxicity of pemetrexed due to genetic polymorphisms in the folate pathway has generated interest to explore the pharmacogenetic effects on drug exposure and outcomes.

Objectives:
We evaluated the effect of polymorphisms in the absorption, distribution, metabolism, and elimination (ADME) genes on the pharmacokinetics of pemetrexed in patients with non-squamous NSCLC.

Material and Methods:
This was a pharmacokinetics-pharmacogenetics correlation study. We enrolled 50 adult patients with non-squamous NSCLC who were planned for treatment with pemetrexed and had adequate hematologic, renal, and hepatic functions. The pharmacokinetics samples were collected after pemetrexed administration, either through a traditional or sparse sampling strategy. The levels were determined using a validated Liquid Chromatography - Tandem Mass Spectrometry (LC-MS/MS) method. Six single nucleotide polymorphisms (SNPs) from the patients’ germline deoxyribonucleic acid (DNA) in the solute carrier family 19 member 1 (SLC19A1), methylenetetrahydrofolate reductase (MTHFR), dihydrofolate reductase (DHFR), and gamma-glutamyl hydrolase (GGH) genes were genotyped using the PharmacoScan array platform. The pharmacokinetics parameters were calculated using non-compartmental analysis (NCA) in Pumas v1.1.0 (Pumas-AI Inc., Baltimore, MD). Mann Whitney U test or Kruskal-Wallis test were used to compare the pharmacokinetics parameters across genotypes.

Results:
The observed values of systemic clearance, volume of distribution, maximum plasma concentration (Cmax) and total systemic exposure (AUC0-inf) were 2.47 (1.34) L*h-1, 3.76 (3.0) L, 136.8 (61.95) µg/ml and 314.85 (152.56) µg*h*ml-1, respectively. No clinically relevant covariate effect of ADME gene polymorphisms on the pharmacokinetics of pemetrexed was identified. Cmax and AUC0-inf were not significantly different between the wildtype, heterozygous and homozygous populations for any of the SNPs evaluated.

Conclusion:
ADME gene polymorphisms have no significant effect on the pharmacokinetics of pemetrexed. The evidence is insufficient to support genotype-guided dosing of pemetrexed in patients with non-squamous NSCLC. (Funded by the Indian Council of Medical Research)
Surgical outcome of inferior oblique anteriorization in unilateral superior oblique palsy with large angle hypertropia
Authors: Mansour Mona N. , Hegazy Hanan S. 
Published: March 2024

Purpose
The aim of this study was to assess the effect of unilateral inferior oblique (IO) anteriorization as a single muscle surgery for treatment of unilateral superior oblique palsy (SOP) with large angle hypertropia.

Patients and methods
This is a retrospective study that included 28 patients, for whom IO anteriorization was performed for treatment of ipsilateral SOP with large angle hypertropia more than or equal to 20 prism diopters (PD). The patients were evaluated preoperatively and 3 months postoperatively for the vertical deviation (VD) in primary position and in adduction. Residual hypertropia less than or equal to 6 PD in primary position postoperatively was considered a successful outcome, together with improvement of the abnormal head tilt.

Results
The mean age of the patients was 30.75±17.05 years. The mean preoperative VD in the primary position was 25.29±4.50 PD. It significantly decreased postoperatively to 5.54±5.25 PD (P<0.001). The mean preoperative VD in adduction was 30.57±7.89 PD and decreased postoperatively to 8.50±5.27 PD (P<0.001). The preoperative IO overaction grade was 2.61±0.99 and decreased postoperatively to 0.39±0.50 (P<0.001). Successful outcome was reported in 75% of the cases and improvement of head tilt occurred in 78% of the patients.

Conclusion
IO anteriorization could be a simple one muscle surgery to correct large angle VD associated with unilateral SOP with a favorable outcome.
Testicular Compartment Syndrome in a Case of Fulminant Necrotizing Orchitis
Authors: Das Snehasis , Prakash Sagar , Sunil Julia , Shaikh Oseen Hajilal , Kumbhar Uday Shamrao 
Published: March 2024

Abstract
Testicular compartment syndrome (TCS) impedes the microcirculation in the testicle, resulting from increased venous resistance or an extraluminal compression that might lead to a cascade of hypoxia, ischemia, and gangrene. We report a case of fulminant necrotizing orchitis occurring in a 45-year-old immunocompetent patient in the form of TCS. The patient underwent imaging, which suggested extensive localized right testicular abscess formation, for which the patient underwent guided drainage from the abscess. Subsequently, the patient was started on culture-sensitive intravenous antibiotics. Due to the failure of conservative treatment and symptomatic deterioration, we planned scrotal exploration. Intraoperatively, we found that the testicular tissue was necrotic and completely replaced by frank pus, with an already ruptured tunica, due to higher compartmental pressure. The patient underwent a right orchidectomy. The postoperative course in the hospital was uneventful. We report that this case as TCS is rare, and all surgeons should be aware of such possibility of occurrence.
Navigating the digital landscape: Relationship between type of internet use and well-being among students—A mediation and moderation analysis
Authors: Dolly Sapam Kiran , Samantaray Narendra Nath 
Published: March 2024

Background:The amount and frequency of internet use are often used to forecast its pros and cons, with mixed findings. After COVID-19, technological advances and sociological upheavals have shown the internet’s ability to support numerous activities, necessitating a change in internet use. Beyond internet use frequency, it has been advised to examine why people use it and how it affects their well-being. Hence, we aimed to investigate the various mediators and moderators in the relationship between the quality of internet use (type of activity) and well-being. Further, we investigated whether user attributes such as initial age and frequency of internet use moderate the influence of internet use quality on problematic internet use, loneliness, and well-being.Methods:131 students in Manipur who were 18 years old were included in this cross-sectional study. Self-rated measures of the Adult Internet Usage questionnaire, Internet Addiction Test, and Mental Health Continuum-Short Form assessed internet use, dependence, and well-being.Results:Loneliness mediates the association between well-being and internet behaviors related to personal use-self-actualization (BootSE = .53, BootLLCI = .10, BootULCI = 2.18), cultural use-belonging (BootSE =.57, BootLLCI = -2.23, BootULCI = -.02). Average online hours moderate economic use-education, loneliness, and well-being (BootSE =.13, BootLLCI = -.55, BootULCI = -.04).Conclusion:To conclude, the effectiveness of internet use affects well-being differently depending on the type of activity. After a certain point, even seemingly good internet activities may have diminishing returns.
Understanding Patient–Doctor Relationship via a Sample of Iraqi Doctors
Authors: Alkhudhairi Jamal Mahmood 
Published: March 2024

Abstract

Background:
Rapid changes in health-care delivery system and sociopolitical climate have resulted in considerable strain on doctor–patient relationship. Doctors’ role is to install positive energy within the patient, through which sick people find relief from suffering. Without it, there continues to be more confusion, fear, and doubt.

Objective:
This study aims to understand the social dimensions of Iraqi doctor misbehavior and malcommunication with patients.

Subjects and Methods:
A cross-sectional study, with a tool consisting of two sketch drawings representing an agonizing misbehavior scenario for a female gynecologist encountering a pregnant patient, and a male orthopeditian encountering a disabled male patient. Scenarios were presented to a convenient sample of 155 Iraqi doctors in Baghdad, striking their feelings, to generate rich comments.

Results:
About two-thirds of doctors were female, and the majority were nonspecialists. Only 7.1% of doctors (with significant gender difference) offered an excuse for the misbehavior. Around 80% of doctors expressed patient sympathy. Scenario understanding showed significant doctors’ gender difference. Two-thirds of doctors stated reasons and suggested solutions for the misbehavior. Main reasons stated were commercialization of medicine (23.8%), loss of today’s doctor humanity (18.1%), and profession power and ability to threat (15.2%).

Conclusion:
Although doctor–patient misbehavior is not unprevalent, most Iraqi doctors disagree with it. The majority express professional sympathy. Less than tenth of doctors stand by misbehavior, trying to give excuses. Commercialization of medicine, loss of doctor’s humanity, professional power, and malcommunication are emerging challenges for future Iraqi doctor–patient relation.
A case study of depression: A holistic exploration through the lens of biopsychosocial dynamics
Authors: Sarkar Bubul , Ali Arif , Paul Fayaz Ahmad 
Published: March 2024

Abstract:
Depression is a complex mental health condition influenced by biological, psychological, and social factors. Psychiatric social workers play a crucial role in conducting comprehensive assessments and implementing interventions to address the multi-dimensional nature of depression. This case study seeks to evaluate the psychosocial factors associated with a case of depression and to implement an intervention based on the biopsychosocial approach. This single subject case study explores the effectiveness of the bio-psycho-social model in comprehending depression and its treatment through psychiatric social work intervention. The study employs a pre- and post intervention baseline assessment, utilizing tools such as social history Performa, family assessment device, Beck depression inventory, Self-esteem Scale, Social Adaptive Functioning Evaluation, Multi-dimensional Perceived Social Support Scale, and a family questionnaire. The case referred from the Outdoor Department at Lokopriya Gopinath Bordoloi Regional Institute of Mental Health, Tezpur, Assam, for psychiatric social work assessment and intervention. The results exhibit a significant improvement in pre- and post intervention scores, indicating enhanced daily functioning, reduced depression, increased insight, heightened awareness regarding illness, and improved self-esteem. This study underscores the importance of a biopsychosocial approach in understanding and treating depression comprehensively. The findings emphasize the efficacy of psychiatric social work interventions within this framework, contributing to improved clinical outcomes and facilitating the client’s understanding of their illness. The integration of biological and psychosocial aspects in treatment is essential, necessitating a holistic theoretical paradigm.
Posttreatment symptoms in hypothyroidism and correlations with thyroid-stimulating hormone and free triiodothyronine and free thyroxine: A ThyPRO-based follow-up study
Authors: Davis Ashika , Idiculla Jyothi Mariam 
Published: March 2024

ABSTRACT

Background:
Treatment of primary hypothyroidism with levothyroxine does not fully alleviate its symptoms. Though there have studies to correlate levels of tri-iodothyronine with symptomatology, its role still remains controversial.

Aims:
To study symptoms of hypothyroidism before and after levo-thyroxine therapy using ThyPRO 39 scores and to correlate these with thyroid hormone levels.

Materials and Methods:
This quasi-experimental study was conducted at the in and outpatients’ departments of Internal Medicine and Endocrinology of St John’s Medical College Hospital. Patients were enrolled if they were aged over 18 years and were diagnosed with hypothyroidism (TSH>/= 10 IU/l). Pregnant ladies and patients who had undergone radioiodine therapy or were diagnosed with thyroid cancers were excluded.

Results:
A total of 46 (F=28) patients were enrolled into the study. The mean age of the study group was 41.63 +/-SD 12.078 years.Among hypothyroid symptoms at diagnosis, Tiredness and Emotional Susceptibility had the highest effect size. Tiredness, Cognitive complaints and Depressive symptoms had significant negative correlation with fT3.While Goitre, Tiredness, and Cognitive complaints showed significant association with TSH, no correlations were noted with fT4 and many scores. There was a statistically significant negative correlation between fT3 and post therapy domain scores of Goitre, Tiredness, Impaired Daily Life and Impaired Social Life. There was a significant difference in the QoL domain between those with and without co-morbidities, the latter group having lower scores signifying better QoL.

Conclusion:
Symptoms of hypothyroidism may have a correlation with fT3 levels. Larger well-designed studies with supplementation of T3(triiodothyronine) and correlation with symptoms and tissue levels of fT3 will give conclusive answers.
Review article Railway station in Khabarovsk. History of changes at Khabarovsk-1 station
Authors: Melnikova S. D. 
Published: March 2024

The object of the study is the railway station Khabarovsk-1, Khabarovsk. Particular attention is paid to the reconstruction of the railway station building, the station square with architectural monuments. The analysis of literary and photographic sources traces the history of the creation of the station at various historical stages.The novelty of the study lies in the union of information about the stages of change in the station square and the station building from the beginning of its creation to the present, with the names of architects and sculptors.
Analisis Pengaruh Motivasi Belanja Hedonis, Gratis Ongkir, dan Consumer Review terhadap Pembelian Impulsif pada Konsumen Online Shop
Authors: Khotimah Khusnul , Syafwandi Syafwandi 
Published: March 2024

Analisis Pengaruh Motivasi Belanja Hedonis, Gratis Ongkir, dan Consumer Review terhadap Pembelian Impulsif pada Konsumen Online Shop adalah artikel ilmiah studi pustaka dalam ruang lingkup bidang Ilmu Manajemen Pemasaran. Tujuan penelitian ini ialah untuk membangun hipotesis pengaruh antar variabel yang akan digunakan pada riset selanjutnya. Objek riset pada pustaka online, Google Scholar, Mendeley, dan media online akademik lainnya. Metode riset dengan library research bersumber dari e-book dan open access e-journal. Analisis dengan deskriptif kualitatif. Hasil penelitian ini: 1) Motivasi belanja hedonis berpengaruh terhadap pembelian impulsif; 2) Gratis ongkir berpengaruh terhadap pembelian impulsif; dan 3) Consumer review berpengaruh terhadap pembelian impulsif.
Pengaruh Pengembangan Karir, Komunikasi, Dan Kompensasi Terhadap Kinerja Pegawai Negeri Sipil Di Dinas Kesehatan Kabupaten Rembang
Authors: Ida Pratiwi Vella , Nurhidayati Anik 
Published: March 2024

Penelitian ini melibatkan 97 pegawai negeri sipil yang bekerja di Dinas Kesehatan Kabupaten Rembang. Variabel independen dari penelitian ini adalah kompensasi, komunikasi, dan pengembangan karier, sedangkan variabel dependennya adalah kinerja pegawai. Data diteliti dengan regresi linier berganda. Hasil penelitian menunjukkan bahwa kinerja karyawan dipengaruhi secara signifikan oleh pengembangan karir dan komunikasi, sementara variabel kompensasi tidak mempengaruhi kinerja karyawan. Hasil uji determinasi menunjukkan nilai R2 yang disesuaikan sebesar 0,459, yang berarti bahwa variasi dari empat variabel independen kompensasi, komunikasi, dan pengembangan karir menyumbang 45,9% dari variasi tingkat kinerja pegawai, sementara bagian yang tersisa adalah 54,1% dijelaskan oleh variabel lain yang tidak termasuk dalam penelitian ini.
Kata Kunci: Komunikasi, Kompensasi, Kinerja Pegawai, Pengembangan Karir
Pengaruh Disiplin Kerja, Kemampuan Kerja Dan Lingkungan Kerja Terhadap Kinerja PNS Di Dinas Kesehatan Kabupaten Rembang
Authors: Istiqlali Hani Nur , Lukiarti Ming Ming 
Published: March 2024

Tujuan penelitian ini adalah untuk mengetahui bagaimana disiplin kerja, kemampuan kerja, dan lingkungan kerja memengaruhi kinerja pegawai Negeri Sipil di Dinas Kesehatan Kabupaten Rembang. Disiplin kerja, kemampuan kerja, dan lingkungan kerja adalah variabel independen penelitian, dan kinerja pegawai adalah variabel dependennya. Penelitian ini melibatkan karyawan Dinas Kesehatan Kabupaten Rembang. Dalam metode sampel, seluruh populasi digunakan sebagai sampel jenuh. Penelitian ini melibatkan 97 orang yang bekerja sebagai pegawai negeri sipil di Dinas Kesehatan Kabupaten Rembang. Uji instrumen, regresi linier berganda, dan plot box outlier digunakan untuk menganalisis data. Hasil penelitian ini menunjukkan bahwa disiplin kerja, kemampuan kerja, dan lingkungan kerja berdampak positif terhadap kinerja karyawan. Hasil uji determinasi menunjukkan bahwa nilai Adjusted R2 sebesar 0,786, yang berarti bahwa variasi dari ketiga variabel independen disiplin kerja, kemampuan kerja, dan lingkungan kerja menyumbang 78,6% dari variasi tingkat kinerja karyawan, dan faktor-faktor lain menyumbang 21,4% dari variasi