bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lymphocytes eluted from synovial tissue of juvenile rheumatoid arthritis patients
Authors: Abrahamsen Tore G. , Fr øland Stig S. , Natvig Jacob B. , Pahle Jan 
Published: February 2007

AbstractSynovial tissues from 11 patients with juvenile rheumatoid arthritis were investigated. The elution of lymphocytes was performed according to a procedure previously described for synovial tissue of adult rheumatoid arthritis patients (1). The T lymphocytes were predominant (mean: 71%) in all cell suspensions studied, whereas the average proportion of B lymphocytes was 4%. In addition, Fc‐receptor‐bearing lymphocytes were demonstrable (mean: 8%). Transformation of the lymphocytes was induced by the unspecific mitogens phytohemagglutinin, pokeweed mitogen, and concanavallin A, whereas antigens such as PPD and candida albicans antigen were usually ineffective.
Increased spontaneous activity of antibody‐forming cells in the peripheral blood of patients with active sle
Authors: Budman Daniel R. , Merchant E. Bruce , Steinberg Alfred D. , Doft Bernard , Gershwin M. Eric , Lizzio Elaine , Reeves J. Patton 
Published: February 2007

AbstractThirty‐seven patients with criteria for systemic lupus erythematosus (SLE) and 18 normal controls were studied for their spontaneous background IgM antibody plaque‐forming cell number to specific chemical haptens. Active SLE patients had significantly more plaque‐forming cells in their peripheral blood to a total of five chemical determinants than did patients with inactive disease or controls. This increased number of plaque forming‐cells correlated with depressed serum C3 levels by Spearman rank‐order analysis. The finding of elevated numbers of spontaneous IgM plaque‐forming cells to defined chemical haptens supports the concept that active SLE demonstrates a generalized increase in B‐cell activity toward a variety of antigens.
Effects of antiinflammatory agents on the acute response of immune synovitis in rabbits
Authors: Goldlust Marvin B. , Rich Lois C. , Harrity Thomas W. 
Published: February 2007

AbstractImmune synovitis in rabbits was investigated as a potential in vivo model for evaluating new antiinflammatory agents. Antigen‐induced increases in knee width as well as β‐glucuronidase and acid phosphatase activities in exudates were observed. Histologically, polymorphonuclear leukocytes appeared within hours in synovial tissues and reached maximum infiltration at about 24 hours. Subsequently, mononuclear cells, including plasma cells, appeared. The 6‐hour Arthus‐like phase of synovitis can be depressed by some antiinflammatory agents, colchicine and steroids being particularly effective. It is suggested that this model can be utilized to define potentially more effective antiinflammatory drugs.
Increased Frequency of HLA‐Cw3 and HLA‐Dw4 in Rheumatoid Arthritis
Authors: McMichael Andrew J. , Sasazuki Takehiko , McDevitt Hugh O. , Payne Rose O. 
Published: February 2007

AbstractThirty‐nine patients with rheumatoid arthritis were HLA typed for the full range of A and B locus specificities and for Cw3 and Dw4. HLA‐Dw4 was significantly more frequent in patients (36%) than in controls (13%). The frequency of Cw3 was also increased, probably because this allele is in linkage disequilibrium with Dw4.
Monocyte—Reactive Antibodies in Patients with Systemic Lupus Erythematosus
Authors: Arend William P. , Emmerich Toby E. , Sturge Jerrilyn C. , Starkebaum Gordon A. 
Published: February 2007

AbstractCold‐reactive antibodies cytotoxic for peripheral monocytes from more than half of normal donors were found in the sera of 2 of 25 patients with systemic lupus erythematosus (SLE) and 1 of 26 with rheumatoid arthritis (RA), and they were absent in 25 normal sera. In contrast, lymphocytotoxic activity for T or B lymphocytes was found in over half of the lupus sera. The antibodies to monocytes were primarily IgM and exhibited varying specificities. Some of the antibodies were directed against antigenic determinants common to monocytes, T and B cells, or against determinants shared between monocytes and one lymphocyte type. One serum possessed a high titer of antibodies that were specific for monocytes. The clinical significance of antimonocyte antibodies remains to be established.
Lymphocyte Involvement in Rheumatoid Arthritis
Authors: Paulus H. E. , Machleder H. I. , Levine S. , Yu D. T. Y. , Macdonald N. S. 
Published: February 2007

AbstractGrip strength, ring size, duration of morning stiffness, and the number of tender joints improved significantly in 9 patients with severe rheumatoid arthritis during prolonged continuous removal of thoracic duct lymphocytes through a surgical fistula. There was no improvement in 4 subjects in whom surgery failed to establish satisfactory lymph drainage. Reinfusion of unlabeled or 51Cr‐labeled autologous lymphocytes resulted in transient exacerbation of disease activity in 3 subjects. Following reinfusion, some 51Cr‐labeled lymphocytes could be found in the inflamed synovium and synovial fluid by autoradiography, and radioactivity was detected over the joints by surface counting of gamma radiation. Active rheumatoid arthritis recurred in all subjects at variable intervals after cessation of lymph drainage. These findings are compatible with the hypothesis that some of the lymphocytes in the thoracic duct lymph are essential for the continued activity of the inflammation associated with rheumatoid arthritis.
Computer analysis of factors influencing frequency of infection in systemic lupus erythematosus
Authors: Ginzler Ellen , Diamond Herbert , Kaplan David , Weiner Max , Schlesinger Michael , Seleznick Mitchel 
Published: February 2007

AbstractData from a prospective study of the clinical course in 223 patients with systemic lupus erythematosus followed for 655 patient‐years were analyzed by computer to determine the influence on frequency of infection of 1) corticosteroid dose; 2) azathioprine; 3) active disease, measured by new disease exacerbations, elevated ESR, hypocomplementemia, active urinary sediment, and proteinuria; 4) uremia; and 5) leukopenia. The frequency of all infections, and of bacterial and opportunistic infections specifically, increased progressively with increasing steroid dose. Azathioprine use, independent of steroid dose, did not account for an increased risk of bacterial, opportunistic, or nonspecific viral infections. Leukopenia did not predispose to infection, except possibly when associated with azathioprine‐induced bone marrow suppression. Active renal disease, especially when manifested by abnormal urine sediment, was associated with an increase in infection frequency.
Carpal tunnel syndrome with polymyalgia rheumatica
Authors: Ahmed Tahir , Braun Alan I. 
Published: February 2007

AbstractAssociation of carpal tunnel syndrome with systemic diseases is well established. Carpal tunnel syndrome preceded or existed simultaneously in 5 patients with polymyalgia rheumatica. It is probably related to tenosynovitis resulting in increase in the volume of the contents of the tunnel.
Psychosocial factors in juvenile rheumatoid arthritis
Authors: Henoch Monica Jean , Batson Jean W. , Baum John 
Published: February 2007

AbstractA detailed survey of 88 children with juvenile rheumatoid arthritis (JRA) was made in an attempt to elucidate characteristics that may participate in the etiologic mechanism. Data from a random pediatric population from the same geographic area were also included for comparisons. The most striking findings were psychosocial factors. Children whose parents were unmarried as a result of divorce, separation, or death comprised 28.4% of the JRA population, compared to 10.6% of the comparison group. In addition, adoption occurred three times more often in the JRA population. Fifty‐one percent of these events (divorce, separation, death, or adoption) occurred near the date of onset of the disease.
Ankylosing Spondylitis With Subsequent Development of Rheumatoid Arthritis, Sjögren'S Syndrome, and Rheumatoid Vasculitis
Authors: Clayman Michael D. , Reinertsen James L. 
Published: February 2007

AbstractTwelve years after the onset of ankylosing spondylitis, a patient developed severe seropositive rheumatoid arthritis with subcutaneous nodules. This was subsequently complicated by Sjögren's syndrome and rheumatoid vasculitis. The literature is reviewed, and the nature of the association between ankylosing spondylitis and rheumatoid arthritis is discussed.
Analysis of dna structure by hydroxyapatite columns and ethidium bromide fluorescence techniques. a comparative study and effect on dna binding
Authors: Davis Paul , Burrington Michael , Russell Anthony S. , Richard Morgan A. 
Published: February 2007

AbstractSeven duplex DNA preparations have been structurally analyzed by hydroxyapatite column chromatography and an ethidium bromide fluorescence technique. Significant contamination of one preparation with single‐stranded DNA was detected by hydroxyapatite column chromatography. Five of the other six preparations were found to contain significant single‐stranded regions by the ethidium bromide fluorescence technique. Synthetic poly dAT was found to be duplex in structure. The presence of single‐stranded regions considerably influenced DNA binding results in a radioimmunoassay.
Horizontal splitting in patellar articular cartilage
Authors: Meachim G. , Bentley G. 
Published: February 2007

AbstractHorizontal splits at the interface between the uncalcified and the calcified layers of the articular cartilage have been found in 31 of 50 transverse slabs of left patellae from a random series of 50 necropsy subjects aged 18 to 96 years. Evidence is presented that the splits are not due to autolysis nor to technical artefact, and it is here suggested that they result from shearing damage at the uncalcified‐calcified cartilage interface during life.
Interrelationship between stimulation of prostaglandin e and hyaluronate production by poly (i).Poly (c) and interferon in synovial fibroblast culture
Authors: Yaron Michael , Yaron Ilana , Wiletzki Chana , Zor Uriel 
Published: February 2007

AbstractThe interferon‐inducer, polyinosinate. Polycyctidylate [Poly (I). Poly (C)] stimulated both prostaglandin E (PGE) and hyaluronic acid (HA) production by human cultured synovial fibroblasts. Increased accumulation of PGE in the medium was noted within 3 hours of culture, while accumulation of HA was observed only after a 24 hour lag period. The stimulation of PGE and HA production by Poly (I) Poly (C) was prevented by aspirin and indomethacin. Human interferon was also effective in stimulating both PGE and HA production. Concomitant addition of cortisol to culture medium abrogated the stimulatory effect of Poly (I). Poly (C) and interferon on both PGE and HA production. Exogenous PGE2, however, overcame the inhibitory effect of cortisol on HA production. The present results suggest that the stimulatory effect of both interferon and Poly (I). Poly (C) on HA production may be mediated by PGE. Prostaglandins may thus play a role in the inflammatory process associated with viral infections.
Central retinal vein occlusion complicating systemic lupus erythematosus
Authors: Silverman Michael , Lubeck Marvin J. , Briney Walter G. 
Published: February 2007

AbstractRetinal lesions occur in 25 to 30% of patients with systemic lupus erythematosus (SLE). Visual loss, however, is rare. A patient who developed central retinal vein occlusion and blindness during the course of active SLE is described. The pertinent literature is reviewed with attention to possible pathophysiologic mechanisms.
Rheumatoid arthritis, amyloidosis, and chylous effusions
Authors: Baim Sanford , Samuelson Cecil O. , Ward John R. , Cathcart Edgar S. 
Published: February 2007

AbstractA patient with rheumatoid arthritis and secondary amyloidosis is described. The initial clinical expression of the amyloidosis was bilateral chylous pleural effusions due to intrinsic amyloid obstruction of the lymphatics. This is an unusual initial manifestation of secondary amyloidosis.
Association of IgG Anti‐Brain Antibodies with Central Nervous System Dysfunction in Systemic Lupus Erythematosus
Authors: Wilson H. Alexander , Winfield John B. , Lahita Robert G. , Koffler David 
Published: February 2007

AbstractSera from 20 patients with systemic lupus erythematosus (SLE) and active central nervous system (CNS) dysfunction were examined by indirect immunofluorescence for antibodies to neuronal membrane determinants. Warm‐reactive IgG antibodies were demonstrable in 82% (9/11) of patients with clinical evidence for seizures or diffuse CNS disease, but these antibodies generally were absent in non‐CNS SLE sera or when focal neurologic deficit or psychosis was the primary CNS manifestation. Cold‐reactive antibodies of the IgM class were equally prevalent in patients with or without CNS disease and appeared to be more directly correlated with extra‐CNS systemic illness. Absorption experiments with lymphocytes, brain homogenate, and various other tissues suggested a predominant brainspecificity for IgG antibodies and partial lymphocyte cross‐reactivity for IgM antibodies. Interpretations of this special association between IgG anti‐brain antibodies and diffuse CNS dysfunction in SLE are discussed.
Studies on the Specificity and Clinical Correlation of Antiribosomal Antibodies in Systemic Lupus Erythematosus Sera
Authors: Koffler David , Miller Thomas E. , Lahita Robert G. 
Published: February 2007

AbstractThe specificity of antibodies reactive with cytoplasmic ribosomes detected in systemic lupus erythematosus (SLE) sera was studied by a radioimmunoassay procedure with 3H labeled HeLa cell polysomes. The antibodies were directed primarily against RNA or a ribosomal RNA‐protein complex (rRNP). Anti‐RNA antibodies exhibited comparable reactivity with ribosomal RNA, nuclear RNA, structural RNA, and a slightly lower degree of reactivity with low molecular weight RNA. Anti‐rRNP antibodies may be detected by precipitation in agar gel and appear to require both the RNA and protein moieties of ribosomes for reactivity. SLE sera containing only anti‐rRNP antibodies are limited to patients with active disease. Sera from patients with both active and inactive SLE contain either anti‐RNA or a mixture of anti‐RNA and anti‐rRNP antibodies. The possible participation of anti‐ribosomal antibodies in immune complex formation is discussed.
The phlogistic potential of urate in solution
Authors: Malawista Stephen E. , Blaricom Gretchen Van , Cretella Stella B. , Schwartz Morris L. 
Published: February 2007

AbstractPhysiologic concentrations of urate in solution had a clear and dosage‐dependent suppressive effect on the concomitant uptake of radioiodinated human serum albumin (131I‐HSA) during the ingestion of particles (bacteria) by human polymorphonuclear leukocytes (PMN). The effect was rapid, reversible on washing the cells, and demonstrable over a wide range of incubation times and ratios of particles to PMN. In this method, the incubated cells are washed, and most surface radio‐activity is thereby removed; the amount of label trapped during particle ingestion then usually provides a sensitive measure of phagocytosis. However, no evidence for an effect of urate on phagocytosis was found by use of several other methods for the assessment of particle uptake, including 1) direct microscopic counts of cell‐associated bacteria, 2) studies in which the bacteria were radiolabeled (instead of the media), and 3) the quantitative recovery of surviving bacteria from the media and from disrupted cells. An alternative explanation for the results with 131I‐HSA is that urate interferes reversibly with the binding of albumin to the cell membrane, including those portions that become internalized during phagocytosis, thereby creating the false impression of less phagocytosis, when there is really only less trapped label (i.e., albumin). In fact, non‐phagocytizing leukocytes—which do not transport albumin across the cell membrane—incubated in serum‐buffer with added urate and with 131I‐HSA and then drained (not washed) had much less cell‐associated radioactivity than controls without added urate. Washing removed the difference (and most of the label from both groups). Crystals of urate and of silica are known to kill the cells that ingest them by disrupting the membranes of phagolysosomes, but only after protective protein has been digested. In the presence of dissolved urate, this inflammatory mechanism might be augmented by the relative lack of protective, membrane‐associated protein. Indeed, as measured by the release of lactic dehydrogenase, injury to cells given silica crystals was augmented considerably in the presence of dissolved urate.
Urate binding to serum albumin
Authors: Holmes Edward W. , Blondet P. 
Published: February 2007

AbstractFractional excretion of uric acid (Curate/Ccreat X 100) was determined in a 4‐year‐old analbuminemic child and an age‐matched control. Fractional excretion of urate was 19% in the analbuminemic child and 24% in the control subject. These values are within the range reported for normal children of this age. We conclude from this study that urate binding to serum albumin is not an important determinant of the renal clearance of uric acid, and by inference there is no significant binding of urate to serum albumin in vivo.
An evaluation of salivary scintigraphy in sögren's syndrome
Authors: Daniels Troy E. , Powell Malcolm R. , Sylvester Robert A. , Talal Norman 
Published: February 2007

AbstractSequential salivary scintigraphy, labial salivary gland biopsy, and measurement of stimulated parotid flow rate were performed in 50 patients suspected of having Sjören's syndrome. The value of these tests in the diagnosis of this disease was compared. Salivary scintigraphy and labial salivary gland biopsy can be used together to disgnose the oral component of Sjören's syndrome. Abnormal salivary scintigraphy correlated with both of the other tests and may be considered optional in the diagnostic evaluation.
Polyarteritis nodosa in childhood
Authors: Ettlinger Robert E. , Nelson Audrey M. , Burke Edmund C. , Lie J. T. 
Published: February 2007

AbstractThe clinical and pathologic findings of 2 infants and 7 older children with polyarteritis nodosa who were autopsied are reported. The most frequent clinical features included prolonged high fever, skin rash, abdominal symptoms, leukocytosis, proteinuria, and signs of either cardiac or renal failure. The 2 infants died of cardiac arrest, whereas renal or neurologic involyement was the most common cause of death in the older children. A consistent finding at autopsy was arteritis of the epicardial coronary arteries.
IgG rheumatoid factor
Authors: Pope Richard M. , Mcduffy Sandra J. 
Published: February 2007

AbstractIgG rheumatoid factor was detected in the sera of the majority of patients with seropositive rheumatoid arthritis. Values suggestive of IgG rheumatoid factor were noted in one‐quarter of patients with seronegative inflammatory arthropathies. These determinations were always low and correlated with elevated IgG concentrations, suggesting nonspecific adherence of IgG rather than a true antigen‐antibody reaction. In support of this conclusion, nonrheumatoid factor IgG was capable of concentration‐dependent nonspecific adsorption to the solid phase. IgG, but not IgM, rheumatoid factor corresponded with disease activity in patients with seropositive rheumatoid arthritis, suggesting that IgG rheumatoid factor may be important in the pathogenesis.
Early complement component depletion and mixed cryoglobulinemia in a “healthy” family
Authors: Waterman John R. , Winkelstein Jerry A. , Berzofsky Ronald N. , Hsu Susan H. , Bias Wilma B. , Arnett Frank C. 
Published: February 2007

AbstractA family containing two apparently healthy brothers with profound early complement component depletion (C1, C4, C2) and mixed IgG‐IgM polyclonal cryoglobulins was studied. The cryoglobulins possessed rheumatoid factor activity and depleted early complement components in normal human serum. Circulating immune complexes could not be detected by utilizing standard methods. The phenomenon was not HLA‐linked. This study demonstrates the familial occurrence of a chronic hypocomplementemic state associated with cryoglobulinemia in clinically normal subjects.
Glomerulonephritis in rheumatoid arthritis
Authors: Davis James A. , Cohen Arthur H. , Weisbart Richard , Paulus Harold E. 
Published: February 2007

AbstractGlomerulonephritis is rarely a complication of rheumatoid arthritis (RA) despite the observation of significant amounts of circulating immune complexes in both glomerulonephritis and RA (1). Among 5,232 patients with a diagnosis of RA, hospitalized at the UCLA Center for the Health Sciences from 1955 to 1977, glomerulonephritis was diagnosed in only 4 patients, all of whom also met diagnostic criteria for systemic lupus erythematosus or mixed connective tissue disease. We present a well documented case of proliferative glomerulonephritis in association with RA in the absence of another immunologically mediated disease.
Lymphocytotoxic antibodies in systemic lupus erythematosus and clinically related diseases
Authors: Schocket Alan L. , Kohler Peter F. 
Published: February 2007

AbstractSera from patients with systemic lupus erythematosus (SLE) and clinically related diseases were examined for cold‐reactive lymphocytotoxic antibodies (LCA). The incidence of LCA was significantly increased in SLE (93%), discoid lupus (50%), and “lupuslike” syndromes associated with congenital complement deficiencies (63%) as compared to normal controls (3%) and patients with drug‐induced lupus (11%), mixed connective tissue disease (MCTD) (17%), and necrotizing vasculitis (19%). The diagnostic and pathogenetic implications of these differences are discussed.
Accelerated appearance of neoplasms in female nzb/nzw mice treated with high‐dose cyclophosphamide
Authors: Walker Sara E , Anver Miriam R 
Published: February 2007

AbstractProlonged immunosuppressive therapy with cyclophosphamide increases the prevalence of neoplasms in NZB/NZW mice, an animal model of systemic lupus erythematosus. The current study was designed to compare the oncogenic properties of high dose cyclophosphamide with a low dose therapeutic regimen. Female NZB/NZW mice received life‐long therapy with “high dose” cyclophosphamide, 16 mg/kg/day, or “low dose” cyclophosphamide, 5.7 mg/kg/day; control mice received saline. High dose therapy clearly accelerated appearance of neoplasms. Seventeen of 19 mice treated with high‐dose cyclophosphamide developed neoplasms at the mean age of 61 weeks. Fifty‐seven percent of these tumors were mammary carcinomas. Neoplasms appeared in all mice treated with low dose; mean longevity in this treatment group was 80 weeks (compared to high dose treated mice, P < 0.001). Carcinomas, pulmonary adenomas, and lymphomas were the most common tumors in mice receiving low dose therapy. Positive tests for ANA were suppressed in high dose treated mice. AntiDNA antibody levels and glomerulonephritis were decreased significantly in both groups of cyclophosphamide‐treated mice compared to controls. It was concluded that the high daily dose of immunosuppressive drug was related to early oncogenesis in autoimmune NZB/NZW mice.
Culture‐negative septic arthritis and bacterial endocarditis
Authors: Wofsy David 
Published: February 2007

AbstractThe capacity of bacterial endocarditis to mimic other systemic illnesses is well known. This report describes a patient with blood culture‐negative bacterial endocarditis who presented with features suggestive of rheumatoid arthritis. Despite sterile synovial fluid, synovial biopsy culture resulted in identification of the causative organism and led to specific antibiotic therapy and cure. This is the first report of such a case.