bluuebunny/crossref_metadata_2025_split huggingface dataset:
Strengthening Multi‐Factor Authentication Through Physically Unclonable Functions in PVDF‐HFP‐Phase‐Dependent a‐IGZO Thin‐Film Transistors
Authors: Han Youngmin , Lee Subin , Lee Eun Kwang , Yoo Hocheon , Jang Byung Chul 
Published: March 2024

AbstractFor enhanced security in hardware‐based security devices, it is essential to extract various independent characteristics from a single device to generate multiple keys based on specific values. Additionally, the secure destruction of authentication information is crucial for the integrity of the data. Doped amorphous indium gallium zinc oxide (a‐IGZO) thin‐film transistors (TFTs) using poly(vinylidene fluoride‐co‐hexafluoropropylene) (PVDF‐HFP) induce a dipole doping effect through a phase‐transition process, creating physically unclonable function (PUF) devices for secure user information protection. The PUF security key, generated at VGS = 20 V in a 20 × 10 grid, demonstrates uniformity of 42% and inter‐Hamming distance (inter‐HD) of 49.79% in the β‐phase of PVDF‐HFP. However, in the γ‐phase, the uniformity drops to 22.5%, and inter‐HD decreases to 35.74%, indicating potential security key destruction during the phase transition. To enhance security, a multi‐factor authentication (MFA) system is integrated, utilizing five security keys extracted from various TFT parameters. The security keys from turn‐on voltage (VON), VGS = 20 V, VGS = 30 V, mobility, and threshold voltage (Vth) exhibit near‐ideal uniformities and inter‐HDs, with the highest values of 58% and 51.68%, respectively. The dual security system, combining phase transition and MFA, establishes a robust protection mechanism for privacy‐sensitive user information.
Realizing High Thermoelectric Performance in GeTe‐Based Supersaturated Solid Solutions
Authors: Liu Xusheng , Wang Wu , Wang Yan , Li Peng , Tang Qiqi , Jia Baohai , Huang Zhenlong , Lin Yuan , Jiang Binbin , He Jiaqing 
Published: March 2024

AbstractAs a highly promising thermoelectric material in the mid‐temperature region, pristine GeTe shows deteriorated thermoelectric properties due to the low Seebeck coefficient and the intrinsic high thermal conductivity. Herein, it is discovered that the introduction of strongly correlated d, f electrons by alloying rare‐earth atoms at Ge sites will increase the band effective mass and promote band convergency, which can largely improve the electric transport property. Moreover, the heavy atoms (Pb, Bi) doping induces optical phonon softening and the avoided crossing between acoustic and optical phonon branches, decelerating both optical and acoustic phonon velocities. The modulated composition wave from the fluctuated multi‐component distribution introduces a complicated hierarchical structure including point defects and nanoprecipitates, which provides all‐scale scattering sources for heat‐carrying phonons and results in low lattice thermal conductivity. Consequently, a high zT of 2.4 at 800 K can be obtained in the Ge0.86Pb0.09Bi0.03Ce0.005Te sample due to the combination of strong correlation for d, f electrons and the full‐spectrum scattering for phonons. This work provides an effective strategy to increase the thermoelectric performance of IV–VI compounds by combining the modulated band structure and the softening phonon dispersion.
Stabilizing Multi‐Electron NASICON‐Na1.5V0.5Nb1.5(PO4)3 Anode via Structural Modulation for Long‐Life Sodium‐Ion Batteries
Authors: Patra Biplab , Hegde Rashmi , Natarajan Anirudh , Deb Debolina , Sachdeva Dorothy , Ravishankar Narayanan , Kumar Keshav , Gautam Gopalakrishnan Sai , Senguttuvan Premkumar 
Published: March 2024

AbstractMulti‐electron NAtrium SuperIonic CONductor (NASICON)‐Nb2(PO4)3 (N0NbP) is an attractive Na‐ion battery anode, owing to its low intercalation voltage (1.4 V vs Na+/Na0) and high capacity (≈150 mAh g−1). However, it suffers from poor capacity retention due to structural degradation. To overcome this issue, extra Na+ ions are introduced at the Na(1) sites, via V3+ substitution, which can act as stabilizing agents to hold lantern units together during cycling, producing NASICON‐Na1.5V0.5Nb1.5(PO4)3 (N1.5VNbP). The N1.5VNbP anode exhibits reversible capacities of ≈140 mAh g−1 at 1.4 V versus Na+/Na0 through Nb5+/Nb4+/Nb3+ and V3+/V2+ redox activities. The extra Na+ ions in the framework forms a complete solid‐solution during Na (de)intercalation and enhances sodium diffusivity, in agreement with first‐principles calculations. Further, N1.5VNbP demonstrates extraordinary cycling (89% capacity retention at 5C after 500 cycles) and rate performances (105 mAh g−1 at 5C). Upon pairing the N1.5VNbP anode with the NASICON‐Na3V2(PO4)3 cathode, the full Na‐ion cell delivers a remarkable energy density of 98 Wh kg−1 (based on the mass of anode and cathode) and retains 80% of its capacity at 5C rate over 1000 cycles. The study opens new possibilities for enhancing the electrochemical performance of NASICON anodes via chemical and structural modulations.
Dual‐Interface Modification for Inverted Methylammonium‐Free Perovskite Solar Cells of 25.35% Efficiency with Balanced Crystallization
Authors: Zheng Yiting , Tian Congcong , Wu Xueyun , Sun Anxin , Zhuang Rongshan , Tang Chen , Liu Yuan , Li Zihao , Ouyang Beilin , Du Jiajun , Li Ziyi , Wu Xiling , Chen Jinling , Cai Jinyu , Chen Chun‐Chao 
Published: March 2024

AbstractIn a methylammonium‐free (MA‐free) composition, the uncontrollable crystallization process between Cs and formamidine (FA) currently hinders its efficiency enhancement, especially in inverted perovskite solar cells (PSCs). Here, a dual‐interface modification of perovskite films is proposed by simultaneously introducing additives and surface passivators. In particular, (aminomethyl)phosphonic acid (AMP) is introduced into the precursor solution to balance crystallization by inducing the preferential crystallization of FA through the specific formation of strong hydrogen bonds with FA. In addition, AMP spontaneously sinks and anchors to the buried interface to fill the voids of the self‐assembled monolayer (SAM) via the covalent bonds formed by ─PO3H2 and FTO. Subsequently, by the sequential modification of perovskite surface with 2‐(3‐fluorophenyl)ethylamine iodide (mF‐PEAI) and piperazine diiodide (PDI), a uniform surface potential is achieved and recombination losses at the interface are minimized. Notably, the dual‐interface‐modified inverted MA‐free PSCs achieve a state‐of‐the‐art power conversion efficiency (PCE) of 25.35% (certified: 24.87%) with a satisfactory Voc of 1.17 V based on the bandgap of 1.52 eV. Importantly, the unencapsulated devices maintain 92.8% and 91.7% of the initial efficiency after 1000 h of maximum power output (MPP) tracking and >800 h of heating at 85 °C, respectively, confirming excellent operational and thermal stability.
Over‐ and Hyper‐Lithiated Oxides as Sacrificial Cathodes for Lithium‐Ion Batteries
Authors: Lee Wontae , Byeon Yun Seong , Lee Seongeun , Kong Sungho , Park Min‐Sik , Yoon Won‐Sub 
Published: March 2024

AbstractBy incorporating sacrificial lithium (Li) sources during electrode fabrication, researchers aim to address the challenge of initial capacity loss due to the formation of a solid electrolyte interphase layer during the early cycles of lithium‐ion batteries (LIBs). This research contributes to the augmentation of Li+ inventory within the electrode to compensate for the irreversible loss of Li+, thereby enhancing the reversibility and cycling performance of LIBs. There are various types of pre‐lithiation additives; however, this perspective specifically discusses over‐ and hyper‐lithiated oxide materials. Within these oxides, research directions are characterized by contrasting approaches aimed at either enhancing the reversibility or inducing the irreversibility of these materials. Intriguingly, both opposing approaches align with the common objective of increasing the energy density of LIBs by providing surplus Li+ to compensate for irreversible Li+ consumption. From this perspective, a concise overview of diverse pre‐lithiation methodologies is provided and the reaction mechanisms associated with over‐ and hyper‐lithiated oxides as sacrificial cathode additives for pre‐lithiation are investigated. Subsequently, strategies to modulate the electrochemical properties of these oxides for practical use in sacrificial cathodes are briefly explored. Following this, discussions are carried out and perspectives on research that adopts the aforementioned contrasting directions are presented.
Effects of health claims on demand structure and market power: The case of the yogurt market in Japan
Authors: Kim Daum , Takahashi Kohya , Maeda Koshi 
Published: March 2024

AbstractThis study aims to clarify the effects of health claims on consumer purchasing behavior and market power, using the Japanese yogurt market as a case study. For the analysis, the Berry, Levinsohn, and Pakes model was applied for estimations using product‐level purchasing data. The main analysis results are as follows. First, consumers prefer brands with lower prices, higher protein, lower fat, lower carbohydrates, and foods for specified health uses (FOSHU). Second, from the value of own‐price elasticity of market shares, the higher the price of a brand, the more sensitively consumers respond to price. From the value of the cross‐price elasticity of market shares, strong competition exists among FOSHU brands, and the price of R‐1 drink types tends to significantly impact the market shares of brands other than FOSHU brands. Third, the market power of each brand tends to be higher for lower‐priced brands and lower for higher‐priced brands. In terms of market power by manufacturer, Meiji has the highest both the weighted average and median values. However, both the weighted average and median values of Danone Japan are relatively lower than those of other manufacturers. Fourth, in terms of each brand's market power, brands with low prices and FOSHU labeling have high market power. These findings suggest that the acquisition of FOSHU brands in the Japanese yogurt market does not lead to a decline in market power (increase in price) and has positive effects for manufacturers, such as an increased market share.
An n‐Type Conjugated Polymer with Low Crystallinity for High‐Performance Organic Thermoelectrics
Authors: Gao Yuexin , Ke Yunzhe , Wang Tianzuo , Shi Yibo , Wang Cheng , Ding Shuaishuai , Wang Yupu , Deng Yunfeng , Hu Wenping , Geng Yanhou 
Published: March 2024

AbstractConjugated polymers (CPs) with low crystallinity are promising candidates for application in organic thermoelectrics (OTEs), particularly in flexible devices, because the disordered structures of these CPs can effectively accommodate dopants and ensure robust resistance to bending. However, n‐doped CPs usually exhibit poor thermoelectric performance, which hinders the development of high‐performance thermoelectric generators. Herein, we report an n‐type CP (ThDPP‐CNBTz) comprising two acceptor units: a thiophene‐flanked diketopyrrolopyrrole and a cyano‐functionalized benzothiadiazole. ThDPP‐CNBTz shows a low LUMO energy level of below −4.20 eV and features low crystallinity, enabling high doping efficiency. Moreover, the dual‐acceptor design enhances polaron delocalization, resulting in good thermoelectric performance. After n‐doping, ThDPP‐CNBTz exhibits an average electrical conductivity (σ) of 50.6 S cm−1 and a maximum power factor (PF) of 126.8 μW m−1 K−2, which is among the highest values reported for solution‐processed n‐type CPs to date. Additionally, a solution‐processed flexible OTE device based on doped ThDPP‐CNBTz exhibits a maximum PF of 70 μW m−1 K−2; the flexible device also shows remarkable resistance to bending strain, with only a marginal change in σ after 600 bending cycles. The findings presented in this work will advance the development of n‐type CPs for OTE devices, and flexible devices in particular.
Characterization of hemicellulose‐carboxymethyl cellulose blend films: Enhancement of the physicochemical, thermal, and mechanical properties
Authors: Abu Hassan Nur Adilah , Fazlina Farah , Teng Leong Pui , Nurul Fazita Mohamad Rawi , Leh Cheu Peng , Kosugi Akihiko , Arai Takamitsu , Chen R. S. , Mohamad Haafiz Mohamad Kassim 
Published: March 2024

AbstractThis study investigates the influence of hemicellulose (Hc) on the chemical composition, thermal stability, mechanical properties, and morphology of carboxymethyl cellulose (CMC). Hc was isolated from oil palm trunk and then added into CMC at 10–30 wt% to prepare Hc‐CMC films via solution casting method. The addition of Hc resulted in reduced visual transparency, rendering the blend films opaque. Fourier transform infrared spectroscopy verified the chemical interaction between Hc and CMC by revealing persistent and robust hydrogen bonding at specific spectral peaks (3483–3045 cm−1). The interaction between Hc and CMC was further indicated by the rougher interfacial structure as revealed in scanning electron microscopy (SEM). Thermal analysis via differential scanning calorimetry and thermogravimetry analysis indicated a decrement in thermal stability as Hc loadings increased in the CMC films. The highest tensile properties were observed in Hc‐CMC blend films at a 20 wt% Hc loading, showcasing notable enhancement about 23%. The 20 wt% Hc‐CMC blend films appeared as more suitable blending composition which having an enhanced physicochemical, thermal, and mechanical properties. This finding underscores its potential applicability in diverse industrial sectors, particularly in packaging applications.
Production and properties of electrically conductive polymer composites reinforced with cotton threads
Authors: Kondratov Alexander P. , Lozitskaya Anastasiya V. , Volinsky Alex A. 
Published: March 2024

AbstractThe problem of strength loss in electrically conductive composites made with dispersed fillers in the polymer binder is solved by spraying an aerosol of graphite on a textile material with a 3D weave of threads, or on knitwear of fibers with various structure and chemical composition. The loose microstructure of cotton fibers and the developed surface of elastic filaments made of synthetic polymers retain colloidal graphite particles in a layered composite during cyclic deformation. The electrical conductivity of knitwear with graphite changes during stretching due to the reversible displacement of graphite particles, first during straightening and then during stretching of elastic threads. The 130 ± 5 strain sensitivity GF and 12,000 ± 95 кPa−1 stress sensitivity QF of the composites presented in this paper exceed the corresponding parameters of known electrically conductive composites. The combination of a significant change in electrical conductivity with the elasticity of the developed knitwear‐based composite is important for the use in load cells, smart clothes, medical devices, and robotics.
Host cell protein networks as a novel co‐elution mechanism during protein A chromatography
Authors: Panikulam Sherin , Hanke Alexander , Kroener Frieder , Karle Anette , Anderka Oliver , Villiger Thomas K. , Lebesgue Nicolas 
Published: March 2024

AbstractHost cell proteins (HCPs) are process‐related impurities of therapeutic proteins produced in for example, Chinese hamster ovary (CHO) cells. Protein A affinity chromatography is the initial capture step to purify monoclonal antibodies or Fc‐based proteins and is most effective for HCP removal. Previously proposed mechanisms that contribute to co‐purification of HCPs with the therapeutic protein are either HCP‐drug association or leaching from chromatin heteroaggregates. In this study, we analyzed protein A eluates of 23 Fc‐based proteins by LC‐MS/MS to determine their HCP content. The analysis revealed a high degree of heterogeneity in the number of HCPs identified in the different protein A eluates. Among all identified HCPs, the majority co‐eluted with less than three Fc‐based proteins indicating a drug‐specific co‐purification for most HCPs. Only ten HCPs co‐purified with over 50% of the 23 Fc‐based proteins. A correlation analysis of HCPs identified across multiple protein A eluates revealed their co‐elution as HCP groups. Functional annotation and protein interaction analysis confirmed that some HCP groups are associated with protein‐protein interaction networks. Here, we propose an additional mechanism for HCP co‐elution involving protein‐protein interactions within functional networks. Our findings may help to guide cell line development and to refine downstream purification strategies.
CaRE@ELLICSR: Effects of a clinically integrated, group‐based, multidimensional cancer rehabilitation program
Authors: Lopez Christian J. , Santa Mina Daniel , Tan Victoria , Maganti Manjula , Pritlove Cheryl , Bernstein Lori J. , Langelier David M. , Chang Eugene , Jones Jennifer M. 
Published: March 2024

AbstractBackgroundAlthough oncology clinical practice guidelines recognize the need and benefits of exercise, the implementation of these services into cancer care delivery remains limited. We developed and evaluated the impact of a clinically integrated 8‐week exercise and education program (CaRE@ELLICSR).MethodsWe conducted a mixed methods, prospective cohort study to examine the effects of the program. Each week, participants attended a 1‐h exercise class, followed by a 1.5‐h education session. Questionnaires, 6‐min walk tests (6MWT), and grip strength were completed at baseline (T0), 8 weeks (T1), and 20 weeks (T2). Semi‐structured interviews were conducted with a sub‐sample of participants about their experience with the program.ResultsBetween September 2017 and February 2020, 277 patients enrolled in the program and 210 consented to participate in the research study. The mean age of participants was 55 years. Participants were mostly female (78%), white/Caucasian (55%) and half had breast cancer (50%). Participants experienced statistical and clinically meaninful improvements from T0 to T1 in disability, 6MWT, grip strength, physical activity, and several cancer‐related symptoms. These outcomes were maintained 3 months after program completion (T2). Qualitative interviews supported these findings and three themes emerged from the interviews: (1) empowerment and control, (2) supervision and internal program support, and (3) external program support.ConclusionsThis study demonstrates the impact of overcoming common organizational barriers to deliver exercise and rehabilitation as part of routine care. CaRE@ELLICSR demonstrated clinically meaningful improvements in patient‐reported and functional outcomes and was considered beneficial and important by participants for their recovery and wellbeing.
The generation of glioma organoids and the comparison of two culture methods
Authors: Zhang Yang , Shao Yunxiang , Li Yanyan , Li Xuetao , Zhang Xuewen , E Qinzhi , Wang Weichao , Jiang Zuoyu , Gan Wenjuan , Huang Yulun 
Published: March 2024

AbstractBackgroundThe intra‐ and inter‐tumoral heterogeneity of gliomas and the complex tumor microenvironment make accurate treatment of gliomas challenging. At present, research on gliomas mainly relies on cell lines, stem cell tumor spheres, and xenotransplantation models. The similarity between traditional tumor models and patients with glioma is very low.AimsIn this study, we aimed to address the limitations of traditional tumor models by generating patient‐derived glioma organoids using two methods that summarized the cell diversity, histological features, gene expression, and mutant profiles of their respective parent tumors and assess the feasibility of organoids for personalized treatment.Materials and MethodsWe compared the organoids generated using two methods through growth analysis, immunohistological analysis, genetic testing, and the establishment of xenograft models.ResultsBoth types of organoids exhibited rapid infiltration when transplanted into the brains of adult immunodeficient mice. However, organoids formed using the microtumor method demonstrated more similar cellular characteristics and tissue structures to the parent tumors. Furthermore, the microtumor method allowed for faster culture times and more convenient operational procedures compared to the Matrigel method.DiscussionPatient‐derived glioma organoids, especially those generated through the microtumor method, present a promising avenue for personalized treatment strategies. Their capacity to faithfully mimic the cellular and molecular characteristics of gliomas provides a valuable platform for elucidating tumor biology and evaluating therapeutic modalities.ConclusionThe success rates of the Matrigel and microtumor methods were 45.5% and 60.5%, respectively. The microtumor method had a higher success rate, shorter establishment time, more convenient passage and cryopreservation methods, better simulation of the cellular and histological characteristics of the parent tumor, and a high genetic guarantee.
Quercetin‐induced degradation of RhoC suppresses hepatocellular carcinoma invasion and metastasis
Authors: Huang Chunlong , Lai Weihua , Mao Shuai , Song Deli , Zhang Jihong , Xiao Xiao 
Published: March 2024

AbstractBackgroundTumor metastasis and recurrence are major causes of mortality in patients with hepatocellular carcinoma (HCC) that is still lack of effective therapeutic targets and drugs. Previous reports implied that ras homolog family member C (RhoC) plays a toxic role on metastasis and proliferation of cancer.MethodsIn this research, the correlation between RhoC and metastasis ability was confirmed by in vitro experiments and TCGA database. We explored whether quercetin could inhibit cell migration or invasion by transwell assay. Real‐time PCR, overexpression and ubiquitination assay, etc. were applied in mechanism study. Primary HCC cells and animal models including patient‐derived xenografts (PDXs) were employed to evaluate the anti‐metastasis effects of quercetin.ResultsClinical relevance and in vitro experiments further confirmed the level of RhoC was positively correlated with invasion and metastasis ability of HCC. Then we uncovered that quercetin could attenuate invasion and metastasis of HCC by downregulating RhoC's level in vitro, in vivo and PDXs. Furthermore, mechanistic investigations displayed quercetin hindered the E3 ligase expression of SMAD specific E3 ubiquitin protein ligase 2 (SMURF2) leading to enhancement of RhoC's ubiquitination and proteasomal degradation.ConclusionsOur research has revealed the novel mechanisms quercetin regulates degradation of RhoC level by targeting SMURF2 and identified quercetin may be a potential compound for HCC therapy.