bluuebunny/crossref_metadata_2025_split huggingface dataset:
Healthcare utilization during acute medically attended episodes of respiratory syncytial virus-related lower respiratory tract infection among infants in the United States
Authors: Gantenberg Jason R. , van Aalst Robertus , Diakun David R. , Bengtson Angela M. , Limone Brendan L. , Nelson Christopher B. , Savitz David A. , Zullo Andrew R. 
Published: February 2025

Background
Respiratory syncytial virus (RSV) is the leading cause of infant hospitalization in the United States. Understanding healthcare utilization associated with medically attended (MA) RSV lower respiratory tract infection (LRTI) might inform research priorities aimed at reducing RSV-associated pediatric morbidity. We described healthcare utilization during acute MA RSV LRTI episodes within a geographically diverse cohort of infants in the United States.

Methods
We created retrospective cohorts of infants born in the United States from July 1, 2016 through February 29, 2020 in each of three de-identified insurance claims datasets: Merative MarketScan Commercial Claims and Encounters, Multi-State MarketScan Medicaid, and Optum’s de-identified Clinformatics ® Data Mart. We identified infants’ first MA RSV LRTI diagnosis during their first RSV season and followed them for 7 subsequent days to record outpatient, emergency department, and inpatient hospital utilization. We calculated the number of outpatient visits, emergency department visits, and inpatient hospital stays occurring during this acute episode and estimated the proportion of episodes involving ≥ 2 visits to a given healthcare setting.

Results
In the CCAE database, we identified 25,409 acute MA RSV LRTI episodes under the specific RSV definition and 69,068 under the sensitive definition. In the MDCD database, these totals were 67,357 and 170,744, while in the CDM database, they were 12,402 and 31,363, respectively. Across data sources, 34%–69% of infants’ first acute MA RSV LRTI episodes involve 2 or more visits to a healthcare setting within 7 days. The percentage of episodes involving at least 2 visits ranged from 34–62% among healthy term infants, 38–65% for Palivizumab-eligible infants, and 38–69% for infants with other comorbidities.

Conclusions
Within a week of their first MA RSV LRTI diagnosis, infants frequently experience at least 2 visits to one or more healthcare settings, regardless of their comorbidity profile. The percentage of MA RSV LRTI episodes involving at least 2 visits to a healthcare setting may vary by insurance claims database, even between commercial payers.
Validity evidence for assessing social-emotional psychological strengths in Colombian adolescents using the SEHS-S
Authors: Riaño-Hernández Diana , Leenen Iwin , Ramírez-Conde Angelli , Atehortua-Rivera Paula A. , Piqueras José A. 
Published: February 2025

Background
Covitality is a multidimensional hierarchical construct of core psychological strengths that synergistically promote resilience and well-being and that has been shown to be effective in preventing mental health problems in individuals of different age groups. The Covitality Model consists of 12 first-order latent factors, 4 second-order factors, and one general higher-order Covitality factor.

Purpose
In this study, we aim at obtaining validity evidence for the assessment of Covitality in Colombian adolescents by means of the Social Emotional Health Survey-Secondary (SEHS-S).

Method
A sample of 1461 adolescents responded the SEHS-S and four other instruments that measure well-being and distress. The internal structure of the SEHS-S was examined through confirmatory factor analyses as well as its relations with other variables.

Results
The hierarchical factor structure of the SEHS-S was supported (with goodness-of-fit statistics: χ2 = 1727.6, df = 578, p < .001; RMSEA = .037; SRMSR = .044; AGFI = .962; CFI = .940; and NNFI = .935) and configural and metric invariance across gender and age was confirmed; however, the assumption of scalar invariance across males and females and across age groups was violated for some items. Furthermore, we found moderate to high correlations (r = .56 –.68) of Covitality with related constructs.

Conclusion
As a conclusion, the SEHS-S can be considered a valid tool to assess psychological strengths, well-being, and resilience (i.e., Covitality) in Colombian adolescents, though further research is needed to explore the differences in item functioning across gender and age.
Adolescent weight management counseling: The effectiveness of an online training program for primary healthcare professionals in Indonesia
Authors: Agung Fransisca H. , Sekartini Rini , Sudarsono Nani , Hendarto Aryono , Werdhani Retno Asti , Dhamayanti Meita , Pudjiati Retno , Hanum Lathifah , Naufal Affan , Sawyer Susan M. 
Published: February 2025

Background
Overweight and obesity are growing public health concerns globally for which innovative prevention and care delivery efforts are required. We recently developed a web-based training program to improve the quality of health professionals’ weight management counseling of adolescents in Indonesia. Having previously confirmed its acceptability, this study aimed to measure the effectiveness of the program through a randomized controlled trial.

Methods
We recruited 64 primary healthcare professionals from 17 provinces across Indonesia who were randomized to participate in a 4-week online training program (intervention group [IG, n = 32] or a waitlist control group [CG, n = 32]). Using active learning approaches, the training program focused on adolescent development, psychosocial assessment, motivational interviewing (MI), and parent engagement. Participants in each arm were asked to record two counseling sessions with adolescents. These were objectively rated by trained psychologists using a validated tool, and also by qualitative assessment of counseling quality. In both groups, the first recorded counseling session occurred before the training. The second recording took place after the training for IG participants, but not for CG participants.

Results
IG participants demonstrated significant improvements in their knowledge and counseling skills (p<0.001, t-test). This included improvements in introductory remarks, quality of psychosocial assessment, and MI skills. There was no change in the extent of parental involvement. The MI training successfully oriented the counseling sessions towards a more collaborative and participatory conversation for supporting behavioral change.

Conclusion
This novel online training program improved the knowledge and counseling skills of Indonesian primary healthcare professionals. Greater emphasis on engaging parents and more guidance on conducting telehealth counseling may improve parental involvement in future iterations.
Outcome of COVID-19 in patients with idiopathic inflammatory myopathy during the Omicron wave in China: A longitudinal observational study
Authors: Li Ying , Tian Xiaolan , Sun Chao , Wei Yangyang , Jiang Wei , He Linrong , Li Chunjia , Zhang Lu , Wang Guochun , Lu Xin 
Published: February 2025

Objective
The coronavirus disease pandemic brought unknown challenges to patients with idiopathic inflammatory myopathy, who are often heavily immunosuppressed and have comorbidities. We aimed to investigate the outcomes and risk factors of coronavirus disease in Chinese patients with idiopathic inflammatory myopathy during the Omicron wave.

Methods
This observational study included patients with idiopathic inflammatory myopathy who visited the China-Japan Friendship Hospital. Data on baseline characteristics and coronavirus disease-related information were collected through medical records and surveys, and subsequently analysed.

Results
Overall, 204 patients with idiopathic inflammatory myopathy were identified; dermatomyositis was the most common idiopathic inflammatory myopathy subtype. Data were collected from 185 patients with idiopathic inflammatory myopathy who tested positive for severe acute respiratory syndrome coronavirus 2 via polymerase chain reaction or antigen tests; of these, 20 experienced a severe course of the disease, and 9 died. All patients with severe coronavirus disease had idiopathic inflammatory myopathy-associated interstitial lung disease, and the most common antibodies observed in patients with mortality were anti-aminoacyl tRNA synthetase and anti-MDA-5 antibodies. Furthermore, 45.0% of patients in the severe disease group took > 15.0 mg of prednisone daily before infection, a significantly higher proportion than that in the non-severe disease group. Advanced age, mechanics’ hands, dyspnoea, chronic cough and fever during the course of myositis, low lymphocyte count, low serum albumin level, and high D-dimer and ferritin levels before infection were prominent in patients with severe coronavirus disease. Albumin levels below 35.0 g/L and ferritin levels above 306.8 ng/mL were independent risk factors of severe coronavirus disease.

Conclusion
Omicron did not worsen the overall outcomes of coronavirus disease for patients with idiopathic inflammatory myopathy; however, specific risk factors were identified, highlighting the need for targeted management strategies.
User experience with pregnancy tracker mobile apps: Findings from comment-based qualitative study
Authors: Hossain Md. Alamgir , Perkins Janet , Hasan Md Tanvir , Lian Sharon Low Bee , Chowdhury Ribica , Alam Md. Tanzirul , Ahmed Anisuddin , Shomik Mohammad Sohel , El Arifeen Shams , Rahman Ahmed Ehsanur , Hossain Aniqa Tasnim , Rahman M. Shafiqur 
Published: February 2025

Background
Worldwide, millions of pregnant women use pregnancy-related apps to monitor their baby’s growth and development. While most of the apps are user-friendly, not all of them are equally appealing. This study aimed to explore the user experience (UX) of pregnancy tracker mobile apps used by pregnant women.

Methods
This study explored the dynamics between users’ experiences and multifaceted dimensions of advanced features, high-quality materials and information, strict privacy policies, problem-solving abilities, and the usefulness of app features and contents. This study applied reviewers’ comment-based qualitative study, accessing crowdsourced data gathered from different pregnancy tracker app websites. A thematic and content analysis approach was used.

Results
This study found that when users are satisfied with using advanced content and features, it aligns with their perceived self-righteousness and rationality, and reflects their cultural values and expectations of using the apps. Conversely, when users encounter challenges such as erroneous baby size comparison and app updating issues, they perceive these as disadvantages of the apps utilised. Moreover, the study sheds light on the specific desires of pregnant women, highlighting their expectations for content that addresses their physical and mental well-being, as well as their unborn babies. The desire for free access reflects the cultural emphasis on cost-effectiveness, while the willingness to invest financially in enhanced experiences demonstrates the recognition of the value and potential benefits of improved content and features. This study also provides valuable insights into the complex relationship between users’ experiences, cultural values, advanced features, high-quality materials and information, privacy policies, problem-solving abilities, and relevant content in creating positive app experiences that align with users’ cultural expectations and needs.

Conclusion
This study provides essential insights into the user experience and underscores the importance of a user-centric design approach for developers. By capturing the current landscape of these digital tools, can provide valuable feedback for the enhancement of existing applications and guide the development of future iterations, ensuring the diverse preferences and expectations of pregnant women worldwide.
Quantifying the impacts of volume-based procurement policy on spatial accessibility of antidepressants via generic substitution: A four-city cohort study using drug sales data
Authors: Xue Aoming , Xue Qingyuan , Fu Jiahong , Fan Keye , Zhang Jiale , Cai Peiyan , Kuang Yuanyuan , Chen Yingsong , Zhou Jifang , Jiang Bin 
Published: February 2025

Objective
To assess the spatial accessibility and inequality of antidepressants and its correlation with VBP (Volume-based procurement) policy using procurement data from four representative Chinese cities between 2018 and 2020.

Methods
The least-cost-path algorithm was employed to calculate travel time from each population point to the nearest medical institution. Gini coefficient and Theil index were utilized to measure accessibility and inequality. OLS (Ordinary Least Squares) and mediation analysis were used to investigate potential statistical relationships.

Results
Under the influence of the VBP policy, we observed varying degrees of growth in the procurement volumes of two antidepressants across different cities (Escitalopram: Beijing 30.3%, Shanghai 26.2%, Ningbo 37.4%, Harbin 25.7%; Paroxetine: Beijing 28.2%, Shanghai 1.2%, Ningbo 50.2%, Harbin 590.5%). The increase in the procurement volumes of antidepressants across cities was primarily driven by generic drugs (Escitalopram: Beijing 159.8%, Shanghai 75.0%, Ningbo 146.4%, Harbin 146.3%; Paroxetine: Beijing 67.3%, Shanghai 4.9%, Ningbo 58.0%, Harbin 15,758.3%). In the results on spatial inequality, we observed annual improvements across all cities, with more pronounced progress in economically underdeveloped regions (Escitalopram: Gini in Harbin decreased by 10.6%; Paroxetine: Gini in Harbin decreased by 32.6%). In Beijing, the substitution of generic escitalopram was found to be a partial mediating factor in the improvement of spatial inequality (ACME = -0.00, p-value = 0.01; ADE = -0.00, p-value = 0.02). In Harbin, the substitution of generic paroxetine was identified as a complete mediating factor for spatial inequality (ACME = -0.04, p-value = 0.01; ADE = 0.01, p-value = 0.14).

Conclusions
This study found that the spatial accessibility and inequality of antidepressant medications gradually improved under the influence of the VBP policy. These improvements can be partially attributed to the substitution of generic drugs.
Effects of whole-body vibration training as an adjunct to conventional rehabilitation exercise on pain, physical function and disability in knee osteoarthritis: A systematic review and meta-analysis
Authors: Peng Yan , Qi Qi , Lee Chai Li , Tay Yan Ling , Chai Siaw Chui , Ahmad Mohd Azzuan 
Published: February 2025

Background
Knee osteoarthritis (KOA) is a prevalent degenerative joint condition that impairs mobility and quality of life. While whole-body vibration training (WBVT) shows promise as an adjunct to conventional KOA rehabilitation, its efficacy remains unclear due to inconsistent clinical evidence.

Objective
To elucidate the combined effects of WBVT and rehabilitation exercise on pain, physical function, and disability in KOA management through a systematic review and meta-analysis.

Methods
A comprehensive search was conducted across eight electronic databases (PubMed, Web of Science, Embase, PEDro, SPORTDiscus, Scopus, ScienceDirect, and China National Knowledge Infrastructure) up to February 2024. Inclusion criteria were (i) randomized controlled trials comparing combined WBVT and rehabilitation exercise versus rehabilitation alone in KOA (ii) reported clinical outcomes (iii) human studies, and (iv) publications in English or Chinese. Trial quality was assessed using the PEDro scale and Cochrane risk-of-bias tool. The meta-analysis employed random-effects models in Review Manager 5.3 to account for heterogeneity, supported by sensitivity analyses for robustness and subgroup analyses on WBVT frequency effects.

Results
Sixteen RCTs comprising 589 participants were included. The systematic review found that WBVT combined with conventional rehabilitation significantly reduced pain and improved physical function in KOA patients. The meta-analysis quantified these effects, showing that WBVT significantly (i) reduced knee pain (MD = −0.43, 95% CI [−0.70, −0.16], p = 0.002), with greater reductions observed from high-frequency WBVT, and (ii) increased isokinetic knee peak torque compared to rehabilitation exercise alone. No significant differences were found in balance, functional mobility, and disability outcomes. Sensitivity analysis of high-quality trials supported these results. However, the heterogeneity among studies and variations in control group interventions warrant cautious interpretation.

Conclusion
WBVT seems to be effective in reducing pain and enhancing muscle strength in KOA patients when used in conjunction with conventional rehabilitation. Future high-quality RCTs must standardize WBVT protocols, emphasize long-term follow-up, and refine dosage for clinically meaningful outcomes.
Systematic review registration: International prospective register of systematic reviews (PROSPERO CRD42024508386)
Factors influencing sepsis associated thrombocytopenia (SAT): A multicenter retrospective cohort study
Authors: Wang Lu , Chen Jieqing , Zhou Xiang ,   on behalf of China National Critical Care Quality Control Centre Group (China-NCCQC)
Published: February 2025

Introduction
Sepsis associated thrombocytopenia (SAT) is a common complication of sepsis. We designed this study to investigate factors influencing SAT.

Methods
Patients with sepsis (2984 in Peking union medical college hospital [PUMCH] database, 13165 in eICU Collaborative Research [eICU] database, 11101 in Medical Information Mart for Intensive Care IV [MIMIC-IV] database) were enrolled. Variables included basic information, comorbidities, and organ functions. Multi-variable logistic regression models and artificial neural network model were applied to determine the factors related to SAT.

Main results
Age and body mass index (BMI) were inversely correlated with the incidence of SAT (p-value 0.175 and 0.049 [PUMCH], p-value 0.000 and 0.000 [eICU], p-value 0.000 and 0.000 [MIMIC-IV]). Hematologic malignancies and other malignancies were positively correlated with the incidence of SAT (p-value 0.000 and 0.000 [PUMCH], p-value 0.000 and 0.000 [eICU], p-value 0.000 and 0.020 [MIMIC-IV]) except other malignancies was inversely correlated with the incidence of SAT in PUMCH database. Norepinephrine (NE) equivalents, total bilirubin (TBIL) and creatinine were positively correlated with the incidence of SAT (p-value 0.000, 0.000 and 0.011 [PUMCH], p-value 0.028, 0.000 and 0.013 [eICU], p-value 0.028, 0.000 and 0.027 [MIMIC-IV]). PaO2 / FiO2 was inversely correlated with the incidence of SAT in PUMCH database (p-value 0.021 [PUMCH]), while it was positively correlated with the incidence of SAT (p-value 0.000 [MIMIC-IV]). PaO2 / FiO2 and SAT was not related (p-value 0.111 [eICU]). TBIL, hematologic malignancies, PaO2 / FiO2 and NE equivalents ranked in the top five significant variables in all three datasets.

Conclusions
Hematologic malignancies and other malignancies were positively correlated with the incidence of SAT. NE equivalents, TBIL and creatinine were positively correlated with the incidence of SAT. TBIL, hematologic malignancies, PaO2 / FiO2 and NE equivalents ranked in the top significant variables in factors influencing SAT.
Growth Response and Carcass Yield of Male Japanese Quail Fed Diets Contained Fermented Rubber (Hevea brasiliensis) Seed Meal
Authors: Hertamawati Rosa Tri , Suryadi Ujang , Prasetyo Anang Febri , Rahmasari Reikha , Imam Shokhirul , Asrianto Noor 
Published: February 2025

This paper discusses the previous research on the use of fermented rubber seed meal using tempeh yeast (Rhizopus oligosporus) (FRSM) given to male quail from 1 to 5 weeks of age on the growth performance and carcass production. The research used a Completely Randomized Design (CRD) experimental method using about 260 male quail aged 0-5 weeks divided into 4 treatment groups with the level of giving fermented rubber seed meal (FRSM) using different fermented yeast, namely R0= feeding without FRSM (control), R1= feeding of 4% FRSM, R2 = feeding of 8% FRSM, and R3= feeding of 12% FRSM. Each treatment was repeated 5 times, making 20 units of 13 male quails. The parameters observed were feed consumption, body weight gain, feed conversion, and carcass production. Rubber seed fermentation in this research showed that rubber seeds' cyanide acid (HCN) content was reduced from 158.64 ppm to 17.84 ppm. The experimental results showed that adding fermented rubber seed meal to the diets did not decrease feed consumption or prevent weight gain, feed conversion, final body weight, carcass weight, and carcass percentage. This research concluded that adding fermented rubber seed meal up to 12% did not harm male quail's growth performance and carcass yield.
PERUBAHAN BUDAYA DALAM TAFSIR AL-QUR’AN (TELAAH TERHADAP PENAFSIRAN MUHAMMAD ABDUH DALAM TAFSIR AL-MANAR)
Authors: Muhsin Imam 
Published: February 2025

Tafsir al-Quran has the position is very important for the life of the people of Islam and its history. Because, with the interpretation of the procedures against the Qur’an, they could develop a global view of the world, history, meaning, and destiny of man. In other words, all legal norms, ethics, moral, political, and intellectual plucked from textual forms of Scripture through interpretation. The fact that the history and culture of the Muslims are not affected by the Qur’an directly, but rather determined by the interpretation of the results (or, at least, the result of the reading) of the Scriptures, to reaffirm the importance of getting the Tafsir of the Qur’an. The efforts to interpret is done by the historical communities in the cultural environment of the concrete and is constantly changing. The changes that inevitably to be followed by tafsir al-Qur’an so that the messages contained therein can be grounded according adagium: al-Qur’an wa makân zamân likulli shâlihun. In the context of this is the interpretation of Muhammad Abduh in his Tafsir al-Manar can be read as a change of culture, through the process of reintegration of value and reorient the meaning.Keywords: Integration, muslim culture and tafsir al-quran
Strongly nonlinear Robin problems for harmonic and polyharmonic functions in the half-space
Authors: Cianchi Andrea , Diebou Gael Y. , Slavíková Lenka 
Published: February 2025

Abstract
Existence and global regularity results for boundary-value problems of Robin type for harmonic and polyharmonic functions in n-dimensional half-spaces are offered.
The Robin condition on the normal derivative on the boundary of the half-space is prescribed by a nonlinear function

𝒩

{\mathcal{N}}

of the relevant harmonic or polyharmonic functions. General Orlicz-type growths for the function

𝒩

{\mathcal{N}}

are considered. For instance, functions

𝒩

{\mathcal{N}}

of classical power type, their perturbations by logarithmic factors, and exponential functions are allowed. New sharp boundedness properties in Orlicz spaces of some classical operators from harmonic analysis, of independent interest, are critical for our approach.
Duality theorems for polyanalytic functions
Authors: Colombo Fabrizio , De Martino Antonino , Diki Kamal , Sabadini Irene , Struppa Daniele C. 
Published: February 2025

Abstract
The goal of this paper is to give a characterization of the dual of the space of polyanalytic functions on the complement of a compact set K and vanishing at infinity. The class of polyanalytic functions generalizes holomorphic functions and serves as a middle ground between holomorphic functions in one complex variable and those in two complex variables. The duality result is also expressed in topological terms through a new class of infinite-order differential operators, which includes well-known families of operators like the Laplace and Helmholtz operators. Since the notion of polyanalytic function generalizes that of holomorphic function, the duality theorems established in this paper can be considered a non-trivial generalization of the Köthe–Grothendieck theorem.