bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the typology of night eating syndrome
Authors: Striegel‐Moore Ruth H. , Franko Debra L. , Thompson Douglas , Affenito Sandra , May Alexis , Kraemer Helena C. 
Published: February 2008

AbstractObjective:There is an ongoing debate about the definitions and clinical significance of night eating syndrome (NES). This study explored potential subtypes based on night eating patterns and features reported to be associated, with NES in a representative community sample of 8,250 individuals aged 15–39 years.Method:Latent class analysis was used to identify NES subtypes among 2,068 participants who reported night eating behavior.Results:A four‐class solution was judged best. Two classes appear to characterize individuals who eat very late or eat a large proportion of their daily intake after 7 pm, and two other classes are characterized by high rates of depressive symptoms. Results do not support an association between night eating and obesity in young adults. Late night eating is associated with high caloric intake, high sodium intake, and low protein intake.Conclusion:Evidence supports the validity of a definition of NES based on eating very late at night. © 2008 by Wiley Periodicals, Inc. Int J Eat Disord 2008
Complex Effect of Partial Substitution of La3+ by Ca2+ on the Stability of Fast Oxide‐Ion Conductor La2Mo2O9
Authors: Selmi Ania , Corbel Gwenaël , Kojikian Stéphanie , Voronkova Valentina , Kharitonova Elena , Lacorre Philippe 
Published: February 2008

AbstractDemixing/recombination and metastability phenomena are observed in the La2–2xCa2xMo2O9–x solid solutions ofLAMOX‐type fast oxide‐ion conductors (0.005 ≤ x ≤ 0.05). The demixing process is more visible at high Ca content. The effects of composition, sample shape (powders with twodegrees of fineness, ceramic pellets, single crystals) and thermal history are studied by using high‐temperature X‐ray diffraction, differential scanning calorimetry (DSC) and polarized microscopy. All these parameters are shown to have an influence on the stability of, and transformations between, the ordered α and the disordered β forms of the LAMOX compounds. Powder samples with low Ca content (x = 0.01, 0.02) have been stabilized in the α form, and powder samples with higher Ca content (x = 0.03, 0.04, 0.05) are in the β form. Upon heating, the low‐Ca‐content compounds (x = 0.01 and x = 0.02) exhibit the α/β transition, whereas those with higher Ca content (x = 0.03 and x = 0.04) show a succession of β/α/β phase transformations (metastability of the β form). The compound with the highest Ca content (x = 0.05) remains in the β form over the whole thermal range. Upon cooling, all samples exhibit the β/α phase transition. When x = 0.04, powder annealing suppresses all the phase transformations upon heating, but not the β/α transition upon cooling, whereas sample shaping/sintering as a pellet stabilizes the β form over the whole thermal range upon heating and cooling. Single crystals with compositions x = 0.005 and x = 0.025 can be obtained either in the α or in the β form by slow cooling or by quenching, respectively. In these oxide‐ion conductors with a high concentration of point defects, internal or external stress appears to strongly affect the vacancy equilibrium but not the demixing/recombination phenomenon.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Synthesis and Anion‐Binding Studies of Thiaphlorins and Covalently Linked Thiaphlorin–Porphyrin Dyads
Authors: Gupta Iti , Fröhlich Roland , Ravikanth Mangalampalli 
Published: February 2008

AbstractA series of thiaphlorins with N2S2 and N3S cores have been prepared in decent yields from readily available precursors. The thiaphlorins were characterized by all spectroscopic techniques and the structures of two thiaphlorins were solved by X‐ray crystallography. The spectral studies indicated that the properties of thiaphlorins were quite different from those of thiaporphyrins. The methodology used for the synthesis of thiaphlorins has been extended to synthesize a series of monofunctionalized thiaphlorins. We also performed functional group transformation of thiaphlorins without decomposition, supporting the conjecture of the stable natures of thiaphlorins. The crystal structure analysis of two thiaphlorins indicated that the macrocycles are not planar and that they each show a marked kink at sp3‐hybridised meso carbon. The functionalized thiaphlorins have been used to synthesize several novel porphyrin–thiaphlorin dyads as well as a bis(thiaphlorin) dyad under mild palladium(0) coupling conditions. Preliminary anion‐binding studies carried out on thiaphlorins and porphyrin–thiaphlorin dyads indicated that they can bind anions effectively in their protonated forms and that these systems can also be used as optical sensors.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Diastereoselective Additions to (3S)‐3‐Aminodehydrocaprolactams: Development of a Versatile Synthesis of New Substituted Cyclic L‐Lysines
Authors: Levraud Camille , Calvet‐Vitale Sandrine , Bertho Gildas , Dhimane Hamid 
Published: February 2008

AbstractEasily obtained cyclic 6,7‐dehydro‐L‐lysine was employed as starting template to generate variously substituted enantiopure 3‐aminocaprolactams. syn‐Dihydroxylation, hydroxymethoxylation, halomethoxylation and subsequent eliminations were performed with this starting enelactam, thus leading, in regio‐ and stereoselective manners, to new mono‐,di‐ and trisubstituted 3‐aminocaprolactams. Structural and mechanistic aspects of these reactions, as well as the origin of the high diastereoselectivities observed in this study are discussed. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Synthesis of Novel Indole‐Based Ring Systems by Acid‐Catalysed Condensation from α‐Amino Aldehydes and L‐Trp‐OMe
Authors: Gomez‐Monterrey Isabel M. , Campiglia Pietro , Bertamino Alessia , Aquino Claudio , Mazzoni Orazio , Diurno Maria V. , Iacovino Rosa , Saviano Michele , Sala Marina , Novellino Ettore , Grieco Paolo 
Published: February 2008

AbstractAcid‐catalysed condensation of tryptophan with different α‐amino aldehyde derivatives has been explored as a useful route to the synthesis of novel amino acid derived heterocycles and peptidomimetic scaffolds. By this approach, compounds containing a tetrahydro‐β‐carboline and a novel octahydropyrrolo[3′,2′:3,4]pyrrolo[2,3‐b]indole system have been efficiently synthesized. Here we report the characterization of these new compounds and preliminary studies of the reactivity of the tetrahydro‐β‐carboline system.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Benzylic Imidazolidinium, 3,4,5,6‐Tetrahydropyrimidinium and Benzimidazolium Salts: Applications in Ruthenium‐Catalyzed Allylic Substitution Reactions
Authors: Yasar Sedat , Özdemir Ismail , Cetinkaya Bekir , Renaud Jean‐Luc , Bruneau Christian 
Published: February 2008

AbstractImidazolidinium, tetrahydropyrimidinium and benzimidazolium salts were prepared. Upon reaction with tBuOK, they generate carbene ligands, which were associated in situ to [RuCp*(MeCN)3]PF6 to produce ruthenium catalysts that are active for the substitution of allylic substrates by dimethyl malonate as a carbonucleophile and phenol. The influences of the N‐heterocyclic structures, as well as that of the benzylic N‐substituents, on the reactivity and regioselectivity were examined.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Characterization of voltage degradation in dynamic field gradient focusing
Authors: Burke Jeffrey M. , Ivory Cornelius F. 
Published: February 2008

AbstractDynamic field gradient focusing (DFGF) is an equilibrium gradient method that utilizes an electric field gradient to simultaneously separate and concentrate charged analytes based on their individual electrophoretic mobilities. This work describes the use of a 2‐D nonlinear, numerical simulation to examine the impact of voltage loss from the electrodes to the separation channel, termed voltage degradation, and distortions in the electric field on the performance of DFGF. One of the design parameters that has a large impact on the degree of voltage degradation is the placement of the electrodes in relation to the separation channel. The simulation shows that a distance of about 3 mm from the electrodes to the separation channel gives the electric field profile with least amount of voltage degradation. The simulation was also used to describe the elution of focused protein peaks. The simulation shows that elution under constant electric field gradient gives better performance than elution through shallowing of the electric field. Qualitative agreement between the numerical simulation and experimental results is shown. The simulation also illustrates that the presence of a defocusing region at the cathodic end of the separation channel causes peak dispersion during elution. The numerical model is then used to design a system that does not suffer from a defocusing region. Peaks eluted under this design experienced no band broadening in our simulations. Preliminary experimental results using the redesigned chamber are shown.
Numerical modeling of Joule heating‐induced temperature gradient focusing in microfluidic channels
Authors: Tang Gongyue , Yang Chun 
Published: February 2008

AbstractTemperature gradient focusing (TGF) is a recently developed technique for spatially focusing and separating ionic analytes in microchannels. The temperature gradient required for TGF can be generated either by an imposed temperature gradient or by Joule heating resulting from an applied electric field that also drives the flow. In this study, a comprehensive numerical model describing the Joule heating induced temperature development and TGF is developed. The model consists of a set of governing equations including the Poisson–Boltzmann equation, the Laplace equation, the Navier–Stokes equations, the energy equations and the mass transport equation. As the thermophysical and electrical properties including the liquid dielectric constant, viscosity, and electric conductivity are temperature‐dependent, these governing equations are coupled, and therefore the coupled governing equations are solved numerically by using a CFD‐based numerical method. The numerical simulations agree well with the experimental results, suggesting the valid mathematical model presented in this study.
Evaluative thinking and action in the classroom
Authors: Nelson Meta , Eddy Rebecca M. 
Published: February 2008

AbstractThis case study of one middle school focuses on improving teachers' skills in datadriven decision making through analysis of student work and their own professional practice. The expectation that schools will make adequate yearly progress has pushed evaluation practice down to the teacher level, where teachers are asked to analyze and disaggregate standardized test scores to facilitate instructional decision making that will lead to increased student achievement. The authors analyze this change in relation to No Child Left Behind and to the literature on evaluation capacity building within schools. © Wiley Periodicals, Inc.
Clock‐drawing potentially mediates the effect of depression on mortality: replication in three cohorts
Authors: Royall Donald R. , Palmer Raymond F. , Chiodo Laura K. , Polk Marsha J. , S. Markides Kyriakos , Hazuda Helen 
Published: February 2008

AbstractObjectivePreviously studies have associated visuospatial tasks, particularly ‘clock‐drawing’, with mortality. We sought to determine whether clock‐drawing also mediates the association between depressive symptoms and mortality.ParticipantsNon‐institutionalized Hispanic and non‐Hispanic White elderly volunteers.MeasurementsSurvival curves were generated as a function of baseline depressive symptom ratings. Significant models were adjusted for CLOX performance. CLOX is divided into CLOX1, a measure of executive control, and CLOX2, a measure of visuospatial skills.DesignRetrospective analysis of three longitudinal cohorts.ResultsCLOX2 and depressive symptoms were both associated with mortality in unadjusted models. CLOX2 predicted survival independently of CLOX1 in all three cohorts. CLOX2 also attenuated, and/or mediated the association between depressive symptoms and mortality. These results withstood adjustment for age and education in all three cohorts.ConclusionRegardless of the sample examined, or the measure of depressive symptoms applied, the association between depressive symptoms and mortality appears to be at least partially mediated by visuospatial skills. This finding supports our hypothesis that right hemisphere structural brain disease, particularly that involving the insula, may mediate depression's effects on mortality. Copyright © 2008 John Wiley & Sons, Ltd.
Differential expression of MUC1 and carbohydrate antigens in primary and secondary head and neck squamous cell carcinoma
Authors: Croce María V. , Rabassa Martín E. , Pereyra Adrián , Segal‐Eiras Amada 
Published: February 2008

AbstractBackgroundIn head and neck squamous cell carcinoma (HNSCC), tumor markers may be helpful to evaluate prognosis accurately as well as to improve therapy selection. Detection of human MUC1 has been widely employed for the evaluation of carcinoma patients. This article aims to study MUC1, Tn, sTn, and Lewis antigenic expression in primary HNSCC, lymph node metastasis, and local recurrences.MethodsWe used immunohistochemistry, tissue homogenization and differential centrifugation, isopycnic density gradient centrifugation, sodium dodecyl sulfate‐polyacrylamide gel electrophoresis, and Western blot.ResultsIn primary tumors, MUC1 was detected in 80.0% of the samples; sLewis x in 23.2%, Lewis x in 45.6%, and Lewis y in 40.8%. Tn and sTn were found in 4.0% and 6.4% of samples, respectively. In metastatic lymph nodes, MUC1 showed a similar positive reaction as in primary tumors. Lewis y was detected in 20% lymph nodes whereas Lewis x, sLewis x, Tn, and sTn did not show differences. Some recurrences expressed MUC1 and only a few Lewis antigens, whereas Tn and sTn were not detected.ConclusionIn primary HNSCC and metastatic nodes, a high expression of MUC1 and Lewis antigens was detected that diminished in local recurrences. We also found that differentiated tumors mainly expressed a linear pattern of MUC1CT and Lewis x. © 2008 Wiley Periodicals, Inc. Head Neck, 2008
Expression of epidermal growth factor receptor and cyclin D1 in pretreatment biopsies as a predictive factor of radiotherapy efficacy in early glottic cancer
Authors: Chang Ah Ram , Wu Hong‐Gyun , Park Charn Il , Jun Yoon Kyung , Kim Chul‐Woo 
Published: February 2008

AbstractBackgroundTo evaluate the prognostic value of the expressions of epidermal growth factor receptor (EGFR) and cyclin D1 in early glottic cancer treated with radiotherapy only.MethodsOne hundred fifty‐one patients with T1‐2, N0 glottic cancer who had been treated with radiotherapy at Seoul National University Hospital since 1992 through 2004. Immunohistochemical staining for EGFR and cyclin D1 were performed on the formalin‐fixed paraffin‐embedded tissues of 25 patients who developed local recurrence and on the tissues of 25 matched patients free from disease. Patterns and degrees of expression were compared between these 2 groups.ResultsHigh EGFR (p = .047) and high cyclin D1 (p = .040) expressions were both found to be significantly associated with a poor prognosis. No association was found between EGFR and cyclin D1 status (p = .158), but EGFR and cyclin D1 status in combination were found to be significantly associated with local control. The patients with both high EGFR and high cyclin D1 expression had the poorest outcome compared with the others (14 months vs 29 months of median time to progression). Patterns of EGFR and cyclin D1 expression changed after recurrence, but these changes were not found to alter the ultimate prognosis.ConclusionThe molecular biomarkers, EGFR and cyclin D1 have a prognostic significance in early glottic cancer. These markers in combination seem to play an important role in tumor relapse and may be useful for selecting patients with a poor outcome after radiotherapy. © 2008 Wiley Periodicals, Inc. Head Neck, 2008
Involved margin of tongue cancer: The impact of tumor satellites on prognosis
Authors: Yang Tsung‐Lin , Ko Jenq‐Yuh , Chang Yih‐Leong 
Published: February 2008

AbstractBackgroundSurgical margin is important to evaluate the adequacy of surgery related to tongue cancer. Despite the distances of margins, tumor components comprising the involved margins should also be investigated. Our aim was to explore the influences of tumor satellites on the clinical outcomes of involved margins.MethodsTwo hundred twenty‐five patients with fresh tongue cancer were investigated. Nineteen patients with pathologically confirmed involved margins were enrolled. Based on the analysis of tumor components of involved margins, they were classified into 2 groups of either tumor‐satellite involved margins (SMs) or main‐tumor involved margins (MMs).ResultsThe results showed that the clinical stages distribution was different: advanced stages in the MM group, and earlier in SM (p = .028). SM group had a higher incidence of neck recurrence (p = .040). Nonetheless, no difference in the disease‐specific survival was noted.ConclusionTumor‐satellite involved margins should be regarded as a worse prognosticator in tongue cancer. © 2008 Wiley Periodicals, Inc. Head Neck, 2008
Value of postoperative radiotherapy in patients with pathologic N1 neck disease
Authors: Jäckel Martin C. , Ambrosch Petra , Christiansen Hans , Martin Alexios , Steiner Wolfgang 
Published: February 2008

AbstractBackgroundThe aim of this study was to assess the efficacy of postoperative radiotherapy for the treatment of patients with pathologic N1 neck disease.MethodsOne hundred eighteen consecutive patients with upper aerodigestive tract cancer who were initially treated with curative surgery between 1986 and 2002 and had pN1 disease without extracapsular spread were reviewed. Postoperative radiotherapy was given to 46 patients.ResultsEight isolated regional recurrences were observed, 3 of which occurred in contralateral undissected necks. Seven of the 72 patients treated with surgery alone and 1 of the 46 who received postoperative radiotherapy were affected. The respective 3‐year neck recurrence rates amounted to 11.2% and 2.9% (p = .0921). A survival benefit of irradiated patients could not be established.ConclusionsThe data confirm a trend toward improved regional control of pN1 disease if postoperative radiotherapy is applied. However, as a survival benefit is uncertain, use of radiation treatment cannot be recommended generally, but requires individual decisions. © 2008 Wiley Periodicals, Inc. Head Neck, 2008
Speech Handicap Index in patients with oral and pharyngeal cancer: Better understanding of patients' complaints
Authors: Rinkel Rico N. , Leeuw Irma M. Verdonck‐de , van Reij Ellen J. , Aaronson Neil K. , Leemans C. René 
Published: February 2008

AbstractBackgroundA Speech Handicap Index (SHI) questionnaire with 30 items on speech problems was developed and validated in 92 patients with cancer of the oral cavity or pharynx and 110 healthy subjects.MethodsAll subjects completed the SHI and the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire–Head & Neck module (QLQ‐H&N35). Twenty‐nine patients completed the SHI twice to assess test–retest reliability.ResultsFactor analysis identified 2 well‐defined subscales, assessing speech function and psychosocial functioning related to speech. Internal consistency and test–retest reliability were high. Construct validity was evidenced by its ability to distinguish between patient subgroups formed on the basis of tumor grade. A cut‐off score of 6 points was defined to identify patients with speech problems.ConclusionsResults of this initial psychometric study indicate that the SHI is a reliable and valid questionnaire for assessing speech problems. Additional research is needed to evaluate responsiveness of the questionnaire to changes in speech‐related problems over time. © 2008 Wiley Periodicals, Inc. Head Neck, 2008
Primary and secondary small cell neuroendocrine carcinoma of the larynx: A review
Authors: Ferlito Alfio , Rinaldo Alessandra 
Published: February 2008

AbstractPrimary laryngeal small cell neuroendocrine carcinoma (SCNC) is an unusual malignancy accounting for <0.5% of laryngeal carcinomas. To date, approximately 200 cases of primary and 5 of secondary SCNC of the larynx have been reported. This tumor most often presents in the sixth and seventh decades in men who are heavy cigarette smokers. The lesion may be associated with different paraneoplastic syndromes (ectopic adrenocorticotropic hormone syndrome, Schwartz–Bartter syndrome or syndrome of inappropriate secretion of antidiuretic hormone, and Eaton–Lambert myasthenic syndrome) or with ectopic hormone production. The diagnosis is based essentially on the histologic appearance of the tumor, confirmed by immunocytochemical investigations. Concurrent chemoradiotherapy regimens offer potential for long‐term survival. This tumor is biologically aggressive, and the extent of the disease is the most significant independent prognostic factor of survival. The survival rate is similar to that with pulmonary SCNC. © 2008 Wiley Periodicals, Inc. Head Neck, 2008
Recurrent laryngeal squamous cell carcinoma: rTNM versus composite laryngeal recurrence staging system. Proposal for a modification of the CLRSS to improve patient classification
Authors: León Xavier , López Montserrat , García Jacinto , Viza Ignacio , Gich Ignasi , Quer Miquel 
Published: February 2008

AbstractBackgroundBased on the initial TNM stage of the tumor and the extension of recurrence, the composite laryngeal recurrence staging system (CLRSS) has been proposed as an alternative to the rTNM system for staging patients with recurrent laryngeal carcinoma. The objective of our study was to carry out an external validation of the CLRSS, and to evaluate a modified version of the original CLRSS, that we named CLRSS‐2.MethodsWe conducted a retrospective analysis of 332 patients with recurrent laryngeal carcinoma treated in our center between 1985 and 2003.ResultsrTNM, CLRSS, and CLRSS‐2 showed a monotonic prognostic gradient with increasing stage and produced significant differences in survival between stages. Discrepancies were detected in the cross‐tabulation between rTNM and CLRSS. The CLRSS‐2 achieved the best results in an objective comparison of the staging systems evaluated.ConclusionThe CLRSS‐2 was the best method to classify patients with a recurrent laryngeal carcinoma. © 2008 Wiley Periodicals, Inc. Head Neck, 2008
Combined endovascular and surgical treatment of carotid body tumor in a patient with thoracic situs solitus
Authors: Pecorari Giancarlo , Roccia Fabio , Nadalin Juri , Giordano Carlo , Garzaro Massimiliano 
Published: February 2008

AbstractBackgroundChemodectomas of the head and neck are tumors that originate from the neural crest. The authors report a case of carotid body tumor with chronic hypoxia secondary to congenital cyanogenic cardiac malformation, radiologically and surgically treated.Methods and ResultsA 37‐year‐old woman presented 1‐year history of a slow‐growing right lateral‐cervical swelling. Radiologic examination led to a suspicion of carotid body tumor. Her history revealed thoracic situs solitus and a complex congenital heart disease. She was hospitalized for a selective angiography of the cervical vessels. Twenty‐four hours later, the tumor was completely removed under local anesthesia. One year later, there were no signs of recurrence, and the patient showed a correct hemodynamic compensation.ConclusionsThe choice of surgical resection with selective preoperative embolization, which induced the obliteration of the feeder vessels, devascularizing the tumor and avoiding significant intraoperative bleeding, was successful. © 2008 Wiley Periodicals, Inc. Head Neck, 2008