bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intramolecular [4+2] cycloaddition of furfurylsubstituted homoallylamines to allylhalides, acryloyl chloride and maleic anhydride
Authors: Varlamov Alexey V. , Boltukhina Ekaterina V. , Zubkov Fedor I. , Nikitina Eugenia V. , Turchin Konstantin F. 
Published: March 2009

Abstractmagnified imageAcylation of 4‐(furyl‐2)‐4‐R‐aminobut‐1‐enes and 4‐R‐4‐furfurylaminobut‐1‐enes with maleic anhydride, acryloyl chloride or allylhalides provided 3‐aza‐10‐oxatricyclo[5.2.1.01,5]decenes. The tricycles are formed via an initial amide formation followed by a stereoselective exo‐IMDAF (Intramolecular Diels‐Alder of Furan). In case of competing cycloaddition (for compounds possessing two furan or two dienophilic moieties) the most substituted fivemembered cycle is preferably annulated. Refluxing of 4‐R‐4‐furfurylaminobut‐1‐enes in acetic anhydride led to exo‐3‐aza‐11‐oxatricyclo[6.2.1.01,6]undecenes with the pseudoequatorial substituent R‐4. Treatment of 3‐aza‐10‐oxatricyclo[5.2.1.01,5]decenes with PPA at 90−110°C promoted cyclic ether opening, aromatization and intramolecular cyclization reactions sequence to give the corresponding tetracyclic compounds — tetrahydroisoindolo[2,1‐a]quinolines and tetrahydroisoindolo[2,1‐b][2]benzazepines in good yields. Unusual products of ipso‐substitution in aromatic ring were obtained on cyclization of N‐p‐R‐substituted 2‐allyl‐4‐oxo‐3‐aza‐10‐oxatricyclo[5.2.1.01,5]dec‐8‐enes.
A facile access to indigodianiles
Authors: Kühn Christiane , Beckert Rainer , Friedrich Manfred , Görls Helmar 
Published: March 2009

Abstractmagnified imageBis‐imidoylchlorides derived from oxalic acid can easily be transformed into the corresponding bis‐imino benzotriazoles. The fact that benzotriazole is a well‐established leaving group has been exploited for an improved synthesis of indigodianiles. Employing metallic lithium, the benzotriazoles can be converted in a cascade reaction into indigo bis‐arylimines in yields up to 45%. Formation of the reduced form of dimeric isocyanides is suggested as a key step.
Microwaves in organic synthesis: Synthesis of pyridazinones, phthalazinones and pyridopyridazinones from 2‐oxo‐arylhydrazones under microwave irradiation
Authors: Al‐Saleh Balkis , El‐Apasery Morsy Ahmed , Hilmy Noha M. , Elnagdi Mohamed H. 
Published: March 2009

Abstractmagnified imageThe phenylhydrazones 1a‐d condensed with ethyl cyanoacetate to yield pyridazinones 2a‐d that reacted with sulphur in presence of piperidine to yield the aminothienopyridazineones 3a,b that reacted with electron poor olefins and acetylenes to yield phthalazines 10‐12. The condensed aminothiophenes 3a,b reacted with dimethylformamide dimethylacetal to yield amidines 13a,b. Compounds 2a,b condensed with dimethylformamide dimethylacetal to yield the trans enamines 16a,b that cyclized readily into the pyridopyridazinones 17a,b on treatment with ammonium acetate in presence of acetic acid. Compounds 2a‐d reacted also with benzylidenemalononitrile to yield the phthalazinones 21a‐d. The reactions were conducted both by microwave heating and conventional heating. Better yields in much shorter reaction times were achieved by microwave heating.
A simple two steps ytterbium triflate‐catalysed preparation of 2,2‐dimethyl‐2h‐chromenes from salicylaldehydes and 2‐methylpropene
Authors: Prado Soizic , Janin Yves L. , Bost Pierre‐Etienne 
Published: March 2009

Abstractmagnified imageThe preparation of various 2,2‐dimethyl‐2H‐chromenes was achieved in two steps via an ytterbium triflate‐catalysed reaction between salicylaldehydes, trimethylorthoformate and 2‐methylpropene. From salicylaldehyde, two reaction products were characterised: 4‐methoxy‐2,2‐dimethylchroman and 2‐(1,3‐dimethoxy‐3‐methylbutyl)phenol. The former compound probably results from a Lewis acid‐catalysed [2+4] cycloaddition between the intermediate quinonemethide and 2‐methylpropene whereas the latter may occur via a reaction related to a carbonyl‐ene reaction between the quinonemethide and 2‐methylpropene. Both compounds were subjected to a catalytic acidic treatment leading to 2,2‐dimethyl‐2H‐chromene. Starting from various salicylaldehydes, the scope of this method was investigated.
An efficient one‐pot synthesis of polyhydrobenzoacridine‐1‐one derivatives under microwave irradiation without catalyst
Authors: Tu Shujiang , Jia Runhong , Jiang Bo , Zhang Yan , Zhang Junyong 
Published: March 2009

Abstractmagnified imageA series of 3,3‐dimethyl‐9‐substituted‐1,2,3,4,9,10‐hexahydrobenzo[c] acridine‐1‐ones and 3,3‐dimethyl‐9‐substituted‐1,2,3,4,9,10‐hexahydrobenzo[a] acridine‐1‐ones were synthesized by the reaction of an aldehyde, α‐naphthylamine or β‐naphthylamine and dimedone under microwave irradiation with short times and high yields.
An efficient one‐pot synthesis of n‐carboxymethylacridine‐1,8‐dione derivatives under microwave irradiation
Authors: Tu Shujiang , Wang Qian , Zhang Yan , Xu Jianing , Zhang Jinpeng , Zhu Xiaotong , Shi Feng 
Published: March 2009

Abstractmagnified imageA series of N‐carboxymethylacridine‐1,8‐dione derivatives were synthesized by one‐pot reaction of aldehyde, dimedone and glycine in glycol under microwave irradiation without catalyst with excellent yields (78‐92%) and short reaction time (4‐8min). And the reaction was not only suitable for aromatic monoaldehyde, but also aromatic dialdehyde.
Reaction of 2‐diazo‐1,2‐diarylethanones with benzophenone n‐(diaryl)acyl hydrazones: Formation of 1,3,4‐oxadiazolines
Authors: Singh Girija S. 
Published: March 2009

Abstractmagnified imageThe reaction of 2‐diazo‐1,2‐diarylethanones with benzophenone N‐(diaryl)acyl hydrazones leads to the formation of 1,3,4‐oxadiazolines. The products have been characterized on the basis of satisfactory analytical and spectral (IR, 1H and 13C NMR, and Mass) data. The mechanism for the formation of products through the reaction of diarylketenes, generated in situ from thermal decomposition of the 2‐diazo‐1,2‐diarylethanones, with imino nitrogen and intramolecular [2 + 3] dipolar cycloaddition is suggested.
Synthesis of novel pyrazole‐linked norcantharidin derivatives of substituted aromatic amines with efficient 1,3‐dipolar cycloaddition
Authors: Deng Liping , Hu Yongzhou 
Published: March 2009

Abstractmagnified imageHighly efficient, practical and convient synthesis of fifteen compounds by the [3+2] 1,3‐dipolar cycloaddition reaction of norcantharidin derivatives of substituted aromatic amines with three hydrazines in the presence of Chloramine‐T.
Synthesis of bis‐intercalators with an aminochloropyrimidine ring as potential anticancer agents
Authors: Zhao Yuxiang , Yuan Hui Liang , Zajíčková Zuzana , Pérkényi Cyril 
Published: March 2009

Abstractmagnified imageThe synthesis of a series of polymethylene chain‐bridged aminochloropyrimidines as potential DNA intercalators is described. N,N'‐Bis(2‐amino‐6‐chloro‐4‐pyrimidyl)‐1,3‐diaminopropane (3), N,N'‐bis(2‐amino‐6‐chloro‐4‐pyrimidyl)‐1,4‐diaminobutane (4), N,N'‐bis(2‐amino‐6‐chloro‐4‐pyrimidyl)‐1,6‐diaminohexane (5), N,N'‐bis(2‐amino‐6‐chloro‐4‐pyrimidyl)‐1,8‐diaminooctane (6), N,N'‐bis(2‐amino‐6‐chloro‐4‐pyrimidyl)‐1,10‐diaminodecane (7), and N,N'‐bis(2‐amino‐6‐chloro‐4‐pyrimidyl)‐1,12‐diaminododecane (8) were synthesized from 2‐amino‐4,6‐dichloropyrimidine (1) and 1,3‐diaminopropane, 1,4‐diaminobutane, 1,6‐diaminohexane, 1,8‐diaminooctane, 1,10‐diaminodecane, and 1,12‐diaminododecane, respectively. The spectral data and other physical properties of the new compounds are discussed.
A novel synthesis of some 2‐imino‐4‐thiazolidinone derivatives
Authors: Moghaddam Firouz Matloubi , Hojabri Leila 
Published: March 2009

Abstractmagnified imageAn efficient and simple route is presented to the synthesis of some iminothiazolidinone derivatives. α‐Chloro amide derivatives undergo coupling reaction with isothiocyanate in the presence of a mild base, followed by nucleophilic substitution of chlorine by the sulfur atom of isothiocyanate.
Synthesis and spectral properties of 7‐(p‐bromophenyl)‐10,10‐dimethyl‐8‐alkylthio‐7,9,10,11‐tetrahydro‐benz[c]acridines and deprotection‐aromatization of 7‐[(o‐; and p‐substituted)phenyl]‐10,10‐dimethyl‐7,8,9,10,11,12‐hexahydrobenz[c]acridin‐8‐thione
Authors: Cortés Eduardo Cortés , García Concepcién Lozada , Montes Karla Sánchez , Obregón Rubén Sánchez , Maya Sandra Cortez , De Cortés Olivia García Mellado 
Published: March 2009

Abstractmagnified imageA series of sixteen new derivatives have been obtained and all have potentially useful pharmacological activity. The treatment of 7‐[(o‐chloro and p‐bromo)phenyl]‐7,8,9,10,11,12‐hexahydrobenz[c]acridin‐8‐one and Lawesson's reagent obtains the corresponding 7‐[(o‐ and p‐substituted) phenyl]‐10,10‐dimethyl‐7,8,9,10,11,12‐hexahydrobenz[c]acridin‐8‐thione II which was alkylated in presence of sodium hydride and the corresponding alkyl iodide under nitrogen atmosphere to obtain 8‐alkylthio‐7,9,10,11‐tetrahydro‐benz[c]acridines III, 1‐4. The thione II was desprotected and aromatized in presence of sodium hydride in absence of nitrogen atmosphere to produce a mixture of 7‐[(o‐ and p‐substituted)phenyl]‐10,10‐dimethyl‐8,9,10,11‐tetrahydrobenz[c]‐acridin‐8‐one IV, 1‐6 and 7‐[(o‐ and p‐substituted)phenyl]‐10,10‐dimethyl‐8‐hydroxi‐8,9,10,11‐tetrahydrobenz[c]acridine V, 1‐6. The structure of all products was corroborated by ir, 1H NMR, 13C NMR with bidimensional experiments and ms with CID experiments.
Studies with azoles and benzoazoles: A novel simple approach for synthesis of 3‐functionally substituted 3‐acylindoles
Authors: Abdel‐Motaleb Ramadan Maawad , Makhloof Abdel‐Moneim Abdel‐Salam , Ibrahim Hamada Mohamed , Elnagdi Mohamed Hilmy 
Published: March 2009

Abstractmagnified image3‐Substituted acylindoles 8 are obtained via refluxing carboxylic acids with indole in acetic anhydride solutions. The formed 3‐substituted acylindole 8a is readily converted into 4‐aminopyrazol‐3‐ylindoles 20, and into 22. Indole reacts with chloroacetyl chloride to yield: 3‐chloroacetylindole 9 which could also be utilized for synthesis of a number of 3‐substituted indoles.
Microwave‐assisted synthesis of 2‐(2‐pyridyl)azoles. Study of their corrosion inhibiting properties
Authors: Likhanova Natalya V. , Martínez‐Palou Rafael , Veloz M. Aurora , Matías Diana J. , Reyes‐Cruz Victor E. , Höpfl Herbert , Olivares Octavio 
Published: March 2009

Abstractmagnified imageAn efficient and fast procedure for the synthesis of 2‐(2‐pyridyl)azoles is described using ionic liquids as catalysts under microwave irradiation. The X‐ray crystallographic analyses for three of the four synthesized compounds are presented. Potentiodynamic polarization studies were carried out to analyze the electrochemical behavior of the compounds in corrosive acidic media. Of the four derivatives, one compound was detected to be an effective corrosion inhibitor prototype for oil refinery environments.
Synthesis and reactions of the thioamide derivatives of methyl vinyl ketone
Authors: Groś Łukasz , Wesołowska Aneta , Westerlich Sławomir , Jagodziński Tadeusz 
Published: March 2009

Abstractmagnified imageThe reaction of isothiocyanates with in situ generated carbanions of α,β‐unsaturated ketones yielded α,β‐unsaturated keto thioamides which in the reaction with acids or bases cyclized to give 2,6‐disubstituted thiopyran‐4‐ones and in the reaction with α‐bromoesters gave thiazolidin‐4‐one derivatives. The thiopyran‐4‐ones reacted with α,β‐unsaturated aldehydes to yield tetrahydrothiopyran[2,3‐b]pyridin‐4‐ones, while thioanilides were formed in the reaction with phenyl isothiocyanate.
One‐pot synthesis of new 3‐substituted coumarins by tandem reactions
Authors: Bourahla Khadidja , Rahmouni Mustapha , Fraga‐Dubreuil Joan , Bazureau Jean Pierre , Hamelin Jack 
Published: March 2009

Abstractmagnified imageThe synthesis of new 3‐substituted coumarins appended to imidazolium, pyridinium, 3‐dimethylamino pyridinium, 3‐chloro pyridinium and 3‐bromo pyridinium salts is reported. These salts were prepared by tandem reactions, followed by quantitative anionic metathesis. The structure of these new 3‐substituted coumarins was established by NMR (1H, 13C) and high‐resolution mass spectrometry.
Synthesis of nitropyrazolidines
Authors: Damavarapu Reddy , Surapaneni Rao , Duddu Raja , Farhor Farhad , Dave Paritosh , Parrish Damon 
Published: March 2009

Abstractmagnified imageSynthesis of 1, 2‐diacetyl‐4, 4‐dinitropyrazolidine 1 and results of further nitration of the 1,2‐diacetyl‐4,4‐dinitropyrazolidine are described.
Azulene‐substituted pyridines and pyridinium salts. Synthesis and structure. 1. Azulene‐substituted pyridines
Authors: Razus Alexandru C. , Birzan Liviu , Pavel Claudia , Lehadus Oana , Corbu Andreea , Chiraleu Filip , Enache Cristian 
Published: March 2009

Abstractmagnified image4‐Azulen‐1‐yl substituted 2,6‐dimethyl‐and 2,6‐diphenyl‐pyridines are obtained in good yields from the reaction of corresponding 4‐azulen‐1‐yl‐pyranylium salts and ammonium acetate in ethanol or starting from 4‐chloro‐2,6‐diphenyl‐pyranylium salts in two steps: reaction with azulenes followed by in situ treatment with ammonium acetate. The effect of substitution at the 3‐position of the heterocycle was taken into account. The structure assignment was accomplished with NMR and uv‐vis spectra.
A new site‐selective route for synthesis of functionalized imidazo[2,1‐c][1,2,4]triazoles
Authors: Shawali Ahmad S. , Abdallah Magda A. , Mosselhi Mosselhi A. N. , Elewa Mahmoud S. 
Published: March 2009

Abstractmagnified imageReactions of 4‐arylhydrazono‐2‐methylthio‐imidazolin‐5(1H)‐one 3 with various hydrazonoyl halides 1 proved to be site‐selective and yielded the respective imidazo[2,1‐c][1,2,4]triazole derivatives 8. The structure of the latter was elucidated by X‐ray analysis and the mechanism of the studied reactions was discussed.
Synthesis of a new series of pyrazolo[1,5‐a]pyrimidines structurally related to zaleplon
Authors: Baraldi Pier Giovanni , Fruttarolo Francesca , Tabrizi Mojgan Aghazadeh , Romagnoli Romeo , Preti Delia , Ongini Ennio , El‐Kashef Hussein , Carrión María Dora , Borea Pier Andrea 
Published: March 2009

Abstractmagnified imageThe reaction between 3‐(dimethylamino)/3,3‐bis(methylthio)‐1‐(substituted)prop‐2‐en‐1‐ones and 4‐substituted‐5‐amino‐1H‐pyrazoles afforded new pyrazole[1,5‐a]pyrimidines structurally related to Zaleplon. The chemical modifications introduced at the 3‐, 5‐, and 7‐positions of the bicyclic structure revealed new promising candidates for the treatment of sleep disorders.
Synthesis and anti‐HIV‐1 activity of 1,3‐phenylene bis‐uracil analogues of MKC‐442
Authors: Aly Youssef L. , Pedersen Erik B. , La Colla Paolo , Loddo Roberta 
Published: March 2009

Abstractmagnified imageReaction of 1,3‐phenylenediacetonitrile with the zinc organometallic reagent of ethyl 2‐bromobutyrate afforded the 1,3‐phenylene‐bis(acetoacetate) 2 which was used as the starting material for the synthesis of 1,3‐phenylene‐bis[6‐(2‐thiouracil)] 4. Desulphurization of 4 gave the corresponding bis‐uracil 6, which after silylation was N‐1 alkylated with bis(allyoxy)methane using TMS‐triflate as the catalyst or with chloromethyl ethyl ether to give the MKC‐442 analogues 7 and 9. The amino‐DABO and S‐DABO derivatives 11, 12a,b and 14 were also synthesized. The anti‐HIV‐1 activity test showed that when MKC‐442 analogues were constructed with 1,3‐phenylene in all cases they were detrimental to have activity against HIV‐1.
Synthesis of alicyclic N‐substituted 1,3‐amino alcohols via 1,3‐oxazines
Authors: Balázs Árpád , Szakonyi Zsolt , Fülöp Ferenc 
Published: March 2009

Abstractmagnified imageAlicyclic N‐substituted 1,3‐amino alcohols 13‐18 were prepared in a facile way in a one‐pot procedure from 1,3‐oxazines 5‐8 in the presence of a ketone 9‐12. The complex reaction involves palladium‐catalyzed reduction, debenzylation and/or transimination and further reduction.
Cyclization reactions of coumarin derivatives: Chemo‐ and regioselectivity effects of oxygen/sulfur isosteric replacement
Authors: Palmisano Giovanni , Toma Lucio , Annunziata Rita , Tagliapietra Silvia , Barge Alessandro , Cravotto Giancarlo 
Published: March 2009

Abstractmagnified imageWe synthesized several sulfur isosters of ferulenol and related prenylcoumarins fromFerula communispreliminary to finding whether the antitubercular activity of these natural compounds might be dissociated from their antithrombin activity. Direct thionation of ferprenine, an instance of “diversity‐oriented” synthesis, yielded a mixture of three thiocoumarin derivatives. When 4‐hydroxy‐2‐deoxy‐2‐thiocoumarin was reacted with farnesal and other α,β‐unsaturated aldehydes, the isosteric oxygen‐sulfur substitution at position 2 surprisingly caused a regiochemical inversion in the tandem Knoevenagel‐electrocyclic reaction, prevalently affording the linear adduct. An extensive investigation with variously substituted enals highlighted a competition between Knoevenagel and Michael addition. This result was rationalized by energy calculations that took into consideration steric and electronic factors as well as complex formation with the catalyst.
Regiospecific synthesis of 5‐(1H‐indol‐2‐yl)‐1‐ and 2‐methyl‐6,7‐dihydro‐2H‐indazole isomers
Authors: Dandu Reddeppareddy , Tao Ming , Josef Kurt A. , Bacon Edward R. , Hudkins Robert L. 
Published: March 2009

Abstractmagnified imageA regiospecific approach to each N‐methyl‐5‐(1H‐indol‐2‐yl)‐6,7‐dihydro‐2H‐indazole isomer is reported. The 1‐methyl isomer 1 was prepared from 5‐bromo‐1‐methyl‐6,7‐dihydro‐1H‐indazole 3 and indole‐2‐boronate 5 by palladium catalyzed Suzuki coupling. The 2‐methyl regioisomer 2 was synthesized via addition of lithium (1‐carboxylato‐1H‐indole‐2‐yl)lithium 6 with 2‐methyl‐2,4,6,7‐tetrahydro‐indazol‐5‐one 8 followed by acid catalyzed dehydration.
A new synthesis method for benzo[f]quinolin‐3‐carbonyl urea and thiourea derivatives in aqueous media catalyzed by TEBAC
Authors: Wang Xiang‐Shan , Zhang Mei‐Mei , Zeng Zhao‐Sen , Shi Da‐Qing , Tu Shu‐Jiang , Wei Xian‐Yong , Zong Zhi‐Min 
Published: March 2009

Abstractmagnified imageA clean and simple synthesis procedure for benzo[f]quinolin‐3‐carbonyl urea and thiourea derivatives was developed based on the reaction between N‐arylidenenaphthalen‐2‐amine and barbituric acid or thiobarbituric acid in aqueous media catalyzed by triethylbenzylammonium chloride (TEBAC). It was interesting that the structures of products in solvent of DMSO‐d6 solution were different from those of the crystal states, which keep the enol form. The products were characterized by 1H NMR, and 13C NMR, and the crystal state was confirmed by X‐ray diffraction study of 3e. In addition, water was chosen as green solvent.
A convenient synthesis of 5‐alkylthio‐3,4‐diarylisoxazoles by palladium‐catalyzed coupling reactions
Authors: Eskandari Roozbeh , Navidpour Latifeh , Amini Mohsen , Shafiee Abbas , Shafaroodi Hamed , Shafiee Abbas 
Published: March 2009

Abstractmagnified imagePalladium‐catalyzed coupling reaction was found effective for rapid access to pharmacologically interesting 3,4‐diarylisoxazoles derivatives as selective COX‐2 inhibitors. Thus, the coupling reaction between 5‐alkylthio‐3‐aryl‐4‐iodoisoxazoles and arylboronic acids afforded the target 5‐alkylthio‐3,4‐diarylisoxazoles in good yields.
New route to pyrimido[4,5‐ e][1,3,4]thiadiazine derivatives
Authors: Rahimizadeh M. , Nikpour M. , Bakavoli M. 
Published: March 2009

Abstractmagnified image5‐Bromo‐2‐chloro‐4‐methyl‐6‐(1‐methylhydrazino)pyrimidine is readily obtained from the recently reported 5‐bromo‐2,4‐dichloro‐6‐methylpyrimidine by treatment with methylhydrazine in chloroform. Treatment of this compound with carbon disulfide and several alkyl halides gave an intermediate which was successfully converted to its corresponding 3‐(alkylsulfanyl)‐7‐chloro‐1,5‐dimethyl‐1H‐pyrimido[4,5‐e][1,3,4]thiadiazine derivatives in basic acetonitrile. The latter compounds were reacted with secondary amines in boiling ethanol to afford the related 7‐amino derivatives.
Regioselective synthesis of quinazoline containing novel monoaryl ethers at room temperature
Authors: Deore Vijaykumar , Lohar Manoj V. , Yewalkar Nilambari , Mundada Ramswaroop , Ranaware Seema , Kumar Sanjay 
Published: March 2009

Abstractmagnified imageWe are herein reporting the regioselective synthesis of quinazoline containing novel monoaryl ethers (quinazoline‐O‐Ar) (3a‐3j) at room temperature without any catalyst. From commercially available 2,4‐dichloro‐6,7‐dimethoxyquinazoline (1), 4‐chloro was selectively substituted with variety of electronically rich, electronically poor and electronically neutral phenols (2a‐2j). Reaction was carried out in DMF and NaH for 4‐6 hours at room temperature in fairly good yield. The products were purified (>98% pure, hplc) by crystallization to avoid the use of column chromatography.
Facile coupling of 2‐(1‐ethylthioethenyl)pyrroles with amines: A route to 2‐(1‐aminoethenyl)pyrroles and 1‐amino‐3‐iminopyrrolizines
Authors: Trofimov Boris A. , Sobenina Lyubov' N. , Mikhaleva Al'bina I. , Petrova Ol'Ga V. , Drichkov Vladislav N. , Ushakov Igor A. , Tarasova Ol'Ga A. , Toryashinova Darya‐Suren D. , Rusakov Yuriy Yu. , Krivdin Leonid B. 
Published: March 2009

Abstractmagnified image2‐(2‐Cyano‐1‐ethylthioethenyl)pyrroles are readily coupled (50–55°) with primary and secondary amines at the position 1 of the ethenyl moiety to eliminate ethanethiol and afford 2‐(1‐amino‐2‐cyanoethenyl)pyrroles and/or their cyclic isomers ‐ functionalized 1‐amino‐3‐iminopyrrolizines in good to high yields.
Synthesis and biological evaluation of new benzo[f]furo[2,3‐h]‐and benzo[f]pyrano[2,3‐h]coumarin derivatives.
Authors: Tsoukka Maria , Litinas Konstantinos E. , Nicolaides Demetrios N. , Hadjipavlou‐Litina Dimitra J. 
Published: March 2009

Abstractmagnified imageFurocoumarins 3,5 and pyranocoumarin 7 were synthesized from the reaction of furonaphthalenediones 2,4 and pyranonaphthalenedione 6 respectively with carbethoxymethylene(triphenyl)phosphorane in refluxing DCM for 3‐6 hours or under microwave irradiation in toluene for a few minutes. Compounds 3,5,7 and their precursors were tested as anti‐inflammatory/antioxidant agents. They were found to compete significantly high DMSO for OH radicals, to scavenge O2− and to inhibit lipoxygenase to a high extent.
Synthesis of tacrine derivatives under solventless conditions
Authors: Khalilzadeh Mohammad A. , Hosseini Abolfazl , Tajbakhsh Mahmoud 
Published: March 2009

Abstractmagnified imageEffects of microwave irradiation on the solid‐phase synthesis of tacrine and its derivatives have been evaluated. Preparation of tacrine analogues under conventional conditions suffers from poor synthetic efficiency and usually gives low yield. Reaction of substituted anthranilonitrile with cyclohexanone under microwave irradiation gave a good to excellent yield of the corresponding substituted 9‐amino‐1,2,3,4‐tetrahydroacridines.
A short synthesis of the hexahydropyrido[4,3‐b]carbazole core structure for the synthesis of aspidosperma alkaloids
Authors: Ergun Yavuz 
Published: March 2009

Abstractmagnified imageA short synthesis of the hexahydropyrido[4,3‐b]carbazole derivative 8 which is important for the preparation of aspidosperma alkaloids was described. Construction of the tetracyclic structure was achieved via a short synthetic route and some new carbazolone derivatives (4, 5, 6 and 7) were synthesized.