bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rehabilitation and Return to Play Protocols After Anterior Cruciate Ligament Reconstruction in Soccer Players: A Systematic Review
Authors: Mayer McKenzie A. , Deliso Marisa , Hong Ian S. , Saltzman Bryan M. , Longobardi Raphael S. , DeLuca Peter F. , Rizio Louis 
Published: April 2024

Background: Rehabilitation after anterior cruciate ligament ACL reconstruction (ACLR) is crucial for safe return to play (RTP) and reducing the chances of a reinjury. Yet, there is no consensus on the ideal functional tests to assess rehabilitation progress in soccer players after ACLR. Purpose: The primary objective was to highlight the existing gap in the literature concerning the most effective standardized rehabilitation protocols and testing for facilitating successful RTP among soccer players. Study Design: Systematic review; Level of evidence, 4. Methods: A systematic review using PubMed, Embase, and the Cochrane Central Register of Controlled Trials (CENTRAL) was conducted. Inclusion criteria encompassed original studies (level of evidence 1-4) that examined rehabilitation protocols, metrics of knee rehabilitation, and clinical outcomes after ACLR in soccer players. Results: This review incorporated 23 studies, predominantly retrospective case series, with a total number of 874 soccer players who underwent ACLR and rehabiliation. 5 (21.7%) studies utilized an accelerated rehabilitation protocol, while 7 (30.4%) of studies utilized a criterion-based rehabilitation. A wide heterogeneity of data was extracted including functional tests of rehabilitation and RTP such as strength test batteries, hop test batteries, and movement quality assessments. Of the 23 selected studies, 2 (8.7%) used all 3 test batteries, 8 (34.8%) used 2 test batteries, 12 (52.2%) used 1 test battery, and 1 (4.3%) used 0 of the test batteries. The mean time between surgery and RTP ranged from 3 to 8 months with only 2 (8.7%) studies reporting complications after ACLR. Lastly, out of the total studies examined, 9 (39.1%) assessed patient-reported outcome measures (PROMs), all of which demonstrated significant improvement from the initial assessment to the final follow up. Conclusion: Soccer-specific rehabilitation after ACLR lacks standardization. Even though many studies have assessed protocols for optimal RTP and reduced secondary ACL injuries, there is a gap in the literature regarding the most effective protocols and RTP testing. The methodology reported by Kyritsis et al could serve as a foundation for future prospective randomized multicenter studies to establish a standard rehabilitation protocol and enable a successful return to soccer.
The pivotal role of the polyethylene glycol amount as compatibilizing on the morphological features of silica-based blends
Authors: Catauro Michelina , Raimondo Marialuigia , Vertuccio Luigi , Guadagno Liberata , D’Angelo Antonio 
Published: April 2024

Silica-based hybrid blends at different molecular or nanometer scale have gained a lot of interests from the technological point of view. In particular, several inorganic-organic hybrids find application in the biomedical field. In this context, inorganic SiO2 and hybrids made up of SiO2 and polyethylene glycol (PEG) have been synthesised via the sol-gel route and characterised from the morphological (throught the Atomic Force Microscopy - AFM) and spectroscopic point of view to shed light on their features as possible hybrid biomaterials. AFM investigation allowed for an effective quantitative evaluation of surface roughness of bioactive sol-gel-based materials. The results revealed an increase in material porosity as a function of the PEG amount in the systems, thus highlighting the pivotal role of the PEG amount as compatibilizing on the morphological features of silica-based blends. The co-presence of both the inorganic and organic phases was confirmed by the Fourier-transform infrared spectroscopy (FT-IR). Moreover, the influence of PEG was also investigated by analysing the deconvoluted FT-IR spectra in the range of 1600-750 cm−1.
Associations Between Self-Reported Visual Difficulty, Age of Onset, and Cognitive Function Trajectories Among Chinese Older Adults
Authors: Xu Shu , Su Yan-Jhu , Ehrlich Joshua R. , Song Qian 
Published: April 2024

Objectives: This study examined the association between self-reported visual difficulty and age-related cognitive declines among older Chinese adults and how the timing of visual difficulty onset plays a role in cognitive trajectories. Methods: Data were drawn from the 2011–2018 wave of the China Health and Retirement Longitudinal Study, involving 9974 respondents aged 60 years or older (mean age 65.44 years, range 60–101 years). Results: At baseline, 14.16% respondents had self-reported visual difficulty. Growth curve models showed that Chinese older adults with visual difficulty experienced a faster decline in cognitive function compared to those without visual difficulty ( β = −0.02, p < .01). Older adults who began experiencing visual difficulty between 61 and 75 years of age had steeper cognitive declines compared to those with earlier or later onset ( β = −0.05, p < .01). Discussion: Older adults with self-reported visual difficulty experience faster rates of cognitive decline. Future research should explore potential factors that underlie the association between onset timing of visual difficulty and cognitive function.
The influence of aniline on the properties of polyaniline nanotubes and their polymerisation mechanism
Authors: Jiao Shengqing , Wang Yanmin , Xiao Yuansong , Han Yongqin , Li Tingxi , Ma Yong 
Published: April 2024

Polyaniline is a kind of polymer material with excellent electrochemical performance, and it stands out among a number of conductive polymer materials owing to its low cost, easy availability of raw materials, and excellent physical and chemical properties. However, the poor processability of polyaniline impedes its broad application. Preparing nanosized structure and introducing big molecular organic acids as dopant are practical strategies to solve this problem. Here using ammonium persulfate as oxidant, sodium dodecyl sulfate as surfactant, and 3,5-dinitrobenzoic acid as doping acid, polyaniline nanotubes were successfully prepared via emulsion polymerization method and characterized by various measurements. The influence of aniline concentration on the morphology and property of the product was explored. The polymerization mechanism of polyaniline nanotubes was discussed in detail based on the analysis of the microscopic morphology. As the concentration of aniline monomer increases, the position of the characteristic absorption peak in the infrared spectrum of the polyaniline main chain remains almost unchanged, but the ratio of benzene to quinone gradually increases. Along with the increasing aniline concentration, the crystallinity of polyaniline gradually decreases from 56.21% to 40.37%. In addition, the optimal conductivity is 2.05×10−2 S/cm when the concentration of aniline monomer is 0.5 mol/L.
Unveiling nurses’ end-of-life care experiences: Moral distress and impacts
Authors: Lee Myung Nam , Kwon So-Hi , Yu SuJeong , Park Sook Hyun , Kwon Sinyoung , Kim Cho Hee , Park Myung-Hee , Choi Sung Eun , Kim Sanghee , Kim Sujeong 
Published: April 2024

Background Nurses providing care to patients with end-of-life or terminal illnesses often encounter ethically challenging situations leading to moral distress. However, existing quantitative studies have examined moral distress using instruments that address general clinical situations rather than those specific to end-of-life care. Furthermore, qualitative studies have often been limited to participants from a single unit or those experiencing moral distress-induced circumstances. A comprehensive and integrated understanding of the overarching process of moral distress is vital to discern the unique circumstances surrounding end-of-life care and its consequential impacts. Research objectives To explore the moral distress experiences of nurses who are frequently involved in caring for patients with end-of-life or terminal illnesses and apply it to two existing theories: the model of moral distress and the ecological model. Research design A qualitative descriptive approach was employed. Participants and research context Seven focus group interviews involving 30 nurses were performed. The subsequent transcriptions underwent rigorous content analysis. Ethical considerations We obtained Institutional Review Board approval from a university. Focus group interviews were conducted with nurses who agreed to participate and signed the consent form. Findings The moral distress-inducing factors and nurses’ perceived impact of moral distress were identified and categorized based on moral distress theories and ecological models. A total of 15 categories and 30 subcategories across the following 4 domains were derived: (1) intrapersonal, (2) interpersonal, (3) organizational, and (4) structural factors. Conclusions End-of-life-specific circumstances induced moral distress among nurses, with both negative and positive impacts identified. Effective organizational and policy support is essential to manage conflicts, form a healthy organizational culture, provide training, and prevent unnecessary expenses due to the negative consequences of moral distress.
A Comprehensive Analysis of Smart Hospital Technologies and Applications – Our Experience and Narrative Review of Literature
Authors: Loria Gaurav , Nayak Yogamaya , Nishit Nishant 
Published: April 2024

Aims and Objectives: This study aims to comprehensively analyze the applications and impact of smart hospital technologies in addressing challenges within India’s health-care system, focusing on patient-centric care, reduced errors, and operational efficiency. Materials and Methods: A detailed examination of smart hospital technologies, including electronic health records, internet of things, artificial intelligence, and telemedicine, was conducted. The study includes a case study of Apollo Hospitals to showcase real-world implementation and outcomes. Results: Smart hospitals leverage advanced technologies to enhance patient experiences and care quality. Verified market research predicts substantial growth in global demand for smart hospital technology, reflecting their transformative potential. Apollo Hospitals’ integration of smart tech positively influenced patient satisfaction, diagnostics, workflows, and data analytics, leading to improved clinical decision-making and coordination of care. Conclusion: The study underscores the compelling need for smart hospitals as a response to India’s health-care challenges. These technologies offer patient-centric care, decreased errors, and optimized workflows. Apollo Hospitals’ case study demonstrates the positive impact of technology integration on patient welfare and operational efficiency. Embracing smart hospitals facilitates innovation, improved outcomes, and enhanced patient experiences, laying the foundation for a brighter and healthier future across socioeconomic spectrums.
Acceptability and feasibility of a short-term group therapy for people with borderline personality disorder symptoms
Authors: Bartsch Dianna R , Cooke-O’Connor Laura , Connerty Tracy J , van Roekel Helen , Cammell Paul 
Published: April 2024

Objective This study evaluated the acceptance, feasibility and safety of a short-term group program for adults (18 years and older) and youth (16 to 18 years) with borderline personality disorder (BPD) symptoms. Termed Road Maps, the content and development were informed by common treatment factors identified from evidence-based therapies for BPD. Method Two-hundred and eight people consented to participate in the research trial and completed baseline measures. Intervention participants rated the acceptability and subjective experience of the group. Attrition rates informed feasibility, and serious adverse events were tracked to identify potential harms. Results Participant post-group ratings of the group’s acceptability and subjective experience were above average across both adult and youth populations. Attrition rate after commencement of group was 38% for adults and 27% among youth. The incidence rate of emergency department presentations was reduced by 41% in the 6 months post-group, relative to 6 months pre-group. Conclusions The current study provides preliminary support for the acceptability and feasibility of a short-term group therapy program for people with a diagnosis of BPD. Road Maps may be a useful intermediate intervention in a broader model of stepped care. Australian New Zealand Clinical Trials Registry, https://www.anzctr.org.au/ACTRN12622000849796.aspx, (ACTRN12622000849796)
Enhancing End-of-Life Care Knowledge Among Older Spanish-Speaking Adults: Results From a Pilot Educational Intervention on Advance Care Planning and Care Options
Authors: Beltran Susanny J. , Molina Olga , Chapple Reshawna 
Published: April 2024

Background Disparities in advance care planning (ACP) among older Latinos necessitate targeted interventions to enhance engagement and knowledge in end-of-life care. This study aimed to evaluate the effectiveness of a resource-efficient, culturally tailored educational intervention in improving ACP readiness and knowledge among older Latino adults in the community. Methods A quasi-experimental pretest-posttest design was used to assess the impact of the intervention. The study involved community-dwelling older Latinos (aged 61-94) in the U.S. attending community wellness centers. Measures included participants’ knowledge of ACP, care options, familiarity with hospice and palliative care, and attitudes toward hospice, assessed using pre- and post-intervention surveys. Results Statistically significant improvements were observed in ACP knowledge, understanding of care options, and attitudes towards hospice and palliative care post-intervention. Demographic factors influenced knowledge scores, with no significant gender differences in the intervention’s efficacy. Conclusions The educational intervention effectively enhanced end-of-life care planning readiness and knowledge among older Latinos. The study highlights the potential for sustainable, accessible, and culturally sensitive educational strategies to reduce disparities in ACP knowledge and possibly engagement.
Investigating Disparities in Hypopharyngeal/Laryngeal Cancer Survival in Florida With Geospatial Mapping Analysis
Authors: Ezeh Uche C. , Al-Awady Abdurrahman , Buitron Isabella , Lee Ming , Forman Garrett , Peifer Sophia , Deo Alana , Sweeny Larissa , Weed Donald , Kobetz Erin K. , Reis Isildinha M , Franzmann Elizabeth 
Published: April 2024

Objective Identify predictors of overall survival (OS) after hypopharyngeal/laryngeal cancer in Florida. Material and Methods We conducted a retrospective cohort study using data from the Florida Cancer Data System (FCDS) on patients diagnosed with hypopharyngeal or laryngeal cancer from 2010-2017. Primary outcome was OS. Hazard ratios (HRs) were estimated from univariable and multivariable Cox regression models for OS. Data was analyzed from November 1, 2022, to June 30, 2023. Results We analyzed 6771 patients, who were primarily male (81.2%), White non-Hispanic (WNH) (78.2%), publicly insured (70.1%), married (51.8%), and residents of urban counties (73.6%). Black patients were more likely to be younger at diagnosis (38.9%), single (43.4%), to have distant SEER stage disease (25.6%). Median OS were lowest among patients who were uninsured (34 months), with hypopharyngeal site disease (18 months), and a smoking history (current: 34 months, former: 46 months, no smoking: 63 months). Multivariable Cox regression analysis showed worse OS for single/unmarried vs married (HR 1.47 [95%CI: 1.36-1.59], P < .001), history of tobacco use (current: HR 1.62 [95%CI: 1.440-1.817], P < .001; former smokers: (HR 1.28 [95%CI: 1.139-1.437], P < .001) vs no history). Improved OS was observed among White Hispanics (WH) vs WNH (HR .73 [95%CI: .655-.817], P < .001) and women vs men (HR .88 [95%CI: .807-.954], P = .002). Geographical mapping showed that mortality rates were highest in census tracts with low income and education. Conclusion Our findings suggest that sociodemographic and clinical factors impact OS from hypopharyngeal/laryngeal cancer in Florida and vary geographically within the state. These results will help guide future public health interventions.
Better Cardiorespiratory Fitness Defined as VO2max Increases the Chance of Partial Clinical Remission and Prolongs Remission Duration in People with Newly Diagnosed Type 1 Diabetes
Authors: Flotyńska Justyna , Naskręt Dariusz , Niedźwiecki Paweł , Grzelka-Woźniak Agata , Pypeć Aleksandra , Kaczmarek Anita , Cieluch Aleksandra , Zozulińska-Ziółkiewicz Dorota , Uruska Aleksandra 
Published: April 2024

Introduction: An essential process affecting the course of type 1 diabetes (DM1) is the appearance and duration of clinical remission. One of the most important factors promoting the occurrence of remission is physical activity, due to increased activity of antioxidants, reduces insulin resistance and improves glucose transport. Maximal oxygen capacity (VO2max) is an objective measure of the body’s aerobic capacity. To assess VO2max, oxygen uptake should be measured directly during the exercise test. The aim of the study was to evaluate the physical capacity in adults with DM1 and its relationship with the occurrence of partial clinical remission (pCR) during 2 years follow-up. Methods: The pCR was assessed by the following mathematical formula: A1c (%) + [4 × insulin dose (U/kg/d)]. The result ⩽9 indicates pCR. VO2max was assessed between 6th and 24th month of diabetes duration using an ergospirometer (COSMED K5 System), during an exercise test carried out on a cycloergometer (RAMP incremental exercise test). Results: The study group consisted of 32 adults with DM1. People with pCR were proved to have higher VO2max level [36.0 (33.0-41.5) vs 30.9 (26.5-34.4) ml/min/kg, P = .009. Univariate and multivariate regression confirmed a significant association between VO2max and presence of pCR [AOR 1.26 (1.05-1.52), P = .015]. Duration of remission was longer among group with higher VO2max results [15 (9-24) vs 9 (0-12) months, P = .043]. The positive relationship was observed between diabetes duration and VO2max (rs = 0.484, P = .005). Multivariate linear regression confirms a significant association between remission duration and VO2max (ml/min/kg) (β = 0.595, P = .002). Conclusion: The higher VO2max, the better chance of partial clinical remission at 2 years of DM1 and longer duration of remission.
MiR-339-5p Inhibits Ferroptosis by Promoting Autophagic Degradation of FTH1 Through Targeting ATG7 in Liver Cancer Cells
Authors: Cao Fei , Hao Weiyuan , Liang Weiren , Zeng Hui , Zheng Jiaping 
Published: April 2024

Background: Liver cancer has a high incidence and mortality rate worldwide, and there is an urgent need to identify new therapeutic strategies and predictive targets to improve the clinical outcomes of advanced liver cancer. Ferroptosis holds promise as a novel strategy for cancer therapy. Epigenetic dysregulation is a hallmark of cancer, and noncoding RNAs are tightly involved in cell fate determination. Therefore, we aimed to identify a novel ferroptosis regulator from aberrantly expressed microRNAs that may serve as a novel biomarker and therapeutic target for liver cancer. Methods: The expression signature and prognostic value of miR-339 was assessed using TCGA data set. The role of miR-339/ATG7/FTH1 axis in liver cancer cells were evaluated through growth curve, colony formation, 7-AAD staining. The role of miR-339 in regulation of ferroptosis was determined by immunofluorescence staining, flow cytometry, and Elisa kits. Results: Here, we showed that miR-339 is aberrantly overexpressed in patients with liver cancer. In addition, miR-339 inhibition dramatically suppresses liver cancer progression. Furthermore, miR-339 silencing drives cell death and inhibits liver cancer progression, indicating that miR-339 may serve as a novel ferroptosis suppressor. Mechanistically, we demonstrated that miR-339 targets ATG7 to facilitate the autophagic degradation of FTH1 and prevent ferroptosis in liver cancer cells. Conclusions: We provide important evidence that the miR-339 inhibition activates of the autophagy pathway to promote ferroptosis by degrading FTH1 in liver cancer cells. We found that miR-339 regulates the balance between ferroptosis and autophagy in liver cancer cells.
Retreatment after primary spontaneous pneumothoraxes managed with primary tube thoracostomy or surgery
Authors: Vilkki Valtteri A. , Kytö Ville , Vilkki Vesa , Gunn Jarmo M. 
Published: April 2024

Background and aims: There is a paucity of data on later healthcare visits and retreatments after primary treatment of spontaneous pneumothorax. The main purpose of this study was to describe retreatment rates up to 5 years after primary spontaneous pneumothorax treated with either surgery or tube thoracostomy (TT) at index hospitalization in Finland between 2005 and 2018 to estimate the burden of primary spontaneous pneumothorax on the healthcare system. Methods: Retrospective registry-based study of patients with primary spontaneous pneumothorax treated with TT or surgery in Finland in 2005–2018. Rehospitalization and retreatment for recurrent pneumothorax and complications attributable to initial treatment were identified. Results: The total study population was 1594 patients. At 5 years, 53.2% (384/722) of TT treated and 33.8% (295/872) of surgically treated patients had undergone any retreatment. Surgery was associated with a lower risk of recurrence than TT (hazard ratio (HR) 0.50, 95% confidence interval (CI) 0.43–0.56, p < 0.001). Male sex was associated with a lower risk of recurrent treatment (HR 0.75, 95% CI 0.63–0.90, p = 0.001). Higher age decreased the risk of recurrent treatment (HR 0.99, 95% CI 0.99–0.99, p < 0.001). At 5 years, 36.0% (260/722) of the TT treated and 18.8% (164/872) of the surgically treated had undergone reoperation at some point. Conclusions: Reintervention rates and repeat hospital visits after TT and surgery were surprisingly high at long-term follow-up. Occurrences of retreatment and reoperation were significantly higher among primary spontaneous pneumothorax patients treated with TT at index hospitalization than among patients treated with surgery.