bluuebunny/crossref_metadata_2025_split huggingface dataset:
North Atlantic Influence on the Glacial Amplitude of East Asian Millennial-Scale Monsoon Variability
Authors: Guo F. , Clemens S. C. , Du X. , Liu X. , Liu Y. , Sun J. , Fan H. , Wang T. , Sun Y. 
Published: April 2024

Abstract
Millennial-scale climate change is thought to be synchronous throughout the Northern Hemisphere and has been demonstrated to be strongly modulated by longer-term glacial–interglacial and orbital-scale processes. However, processes that modulate the magnitude of millennial-scale variability (MMV) at the glacial–interglacial time scale remain unclear. We present multiproxy evidence showing out-of-phase relationships between the MMV of East Asian and North Atlantic climate proxies at the eccentricity band. During most late Pleistocene glacial intervals, the MMV in North Atlantic SST and East Asian monsoon (EAM) proxies shows a gradual weakening trend from glacial inceptions into glacial maxima, inversely proportional to that of the North Atlantic ice-rafted detritus record. The inverse glacial age trends apply to both summer and winter monsoon proxies across the loess, speleothem, and marine archives, indicating fundamental linkages between MMV records of the North Atlantic and East Asia. We infer that intensified glacial age iceberg discharge is accompanied by weakened Atlantic meridional overturning circulation via changes in freshwater input and water column stability, leading to a reduction in North Atlantic SST and wind anomalies, subsequently propagating dampened millennial-scale variability into the midlatitude East Asian monsoon region via the westerlies. Our results indicate that the impact of North Atlantic iceberg discharge and the associated variability in water column stability at the millennial scale is a primary influence on hydroclimate instability in East Asia.
Sildenafil improves hemodynamic changes caused by acute pulmonary embolism by inhibiting Rho kinase activity
Authors: Wang Hui , Li Wei , Yan Yan , Shi Meng-Jie , Hou Feng , Zhang Rui-Peng 
Published: April 2024

Objective This study examined the effects of sildenafil on acute pulmonary embolism (APE) using a rat model. Methods Sprague–Dawley rats were randomly divided into the sham, pulmonary thromboembolism (PTE), and sildenafil groups. The sham and PTE groups received normal saline once daily via gavage for 14 consecutive days, whereas the sildenafil group received sildenafil (0.5 mg/kg/day) once daily via gavage for 14 consecutive days. Autologous emboli were prepared from blood samples collected from the left femoral artery of rats in each group on day 13, and autologous emboli were injected into the jugular vein cannula of rats in the PTE and sildenafil groups on day 14. Sham-treated rats received the same volume of saline. Right systolic ventricular pressure (RVSP) and mean pulmonary arterial pressure (MPAP) were used to assess pulmonary embolism, and western blotting and enzyme-linked immunosorbent assay were used to detect relevant markers. Results The Rho kinase signaling pathway was significantly activated in rats with APE, and sildenafil significantly inhibited this activation. Conclusions Sildenafil protected against APE through inhibiting Rho kinase activity, thereby reducing pulmonary vasoconstriction and decreasing elevated pulmonary arterial pressure. These findings might provide new ideas for the clinical treatment of acute pulmonary thromboembolism.
Differences Between Traumatic and Degenerative Medial Meniscus Posterior Root Tears: A Systematic Review
Authors: Mundal Kristine , Geeslin Andrew G. , Solheim Eirik , Inderhaug Eivind 
Published: April 2024

Background: Intact meniscus roots are a prerequisite for normal meniscal function, including even distribution of compressive forces across the knee joint. An injury to the root disrupts the hoop strength of the meniscus and may lead to its extrusion and the development of osteoarthritis. A medial meniscus posterior root tear (MMPRT) is often thought to have a primary degenerative pathogenesis. However, there is mention of some cases of MMPRTs where the patients have a solely traumatic injury to a previously healthy meniscus. Purpose: To describe a subpopulation of patients with traumatic MMPRT. Study Design: Systematic review; Level of evidence, 5. Methods: The Web of Science database ( www.webofscience.com ) was queried using the Medical Subject Headings term “medial root tear.” Articles were reviewed, and those evaluated for MMPRTs in a degenerative meniscus were excluded. A total of 25 articles describing cases of acute traumatic causes were included in this study. For these articles, the patient characteristics, injury mechanisms, and concomitant injuries evaluated were recorded and pooled. Results: The search revealed 660 articles, and 25 were selected for inclusion. A total of 113 patients with a traumatic MMPRT were identified and included in this review. The study population had a mean age of 27.1 years and a high share of men (64%). Also, this review displays how most patients with traumatic MMPRTs also suffer concomitant injuries (68%). Conclusion: The findings in this review support our hypothesis that there is a unique subgroup with acute traumatic MMPRTs that have unique patient characteristics, injury mechanisms, and combined injuries, compared with previously published reviews on MMPRTs.
Return to Sports Rates in Pediatric Patients After Bilateral Versus Unilateral Medial Patellofemoral Ligament Reconstruction
Authors: Klueh Michael P. , Swany Lauren M. , Troost Jonathan P. , Crawford Eileen A. 
Published: April 2024

Background: Patellofemoral instability commonly occurs during sports activities. The return to sports (RTS) rate for pediatric patients after bilateral medial patellofemoral ligament reconstruction (MPFLR) is unknown. Purpose/Hypothesis: The purpose of this study was to evaluate RTS outcomes for pediatric patients undergoing bilateral MPFLR. It was hypothesized that (1) fewer pediatric patients would RTS after bilateral MPFLR compared with unilateral MPFLR and that (2) for those in the bilateral cohort who were able to RTS, fewer patients would attain the same level of play as or higher level than the preinjury level. Study Design: Cohort study; Level of evidence, 3. Methods: We prospectively collected RTS data on retrospectively identified matched cohorts of patients aged ≤18 years who underwent unilateral and bilateral MPFLR. We matched each participant with bilateral MPFLR at a 1 to 2 ratio with a participant with unilateral MPFLR by concomitant procedure, age, and sex. Postoperative complications and preoperative imaging measurements were collected from medical records. Patient-reported outcomes were obtained using a current Single Assessment Numeric Evaluation score collected at the time of primary outcome data. Results: We matched 16 participants (mean age, 14 years) who underwent bilateral MPFLR to 32 participants (mean age, 14.3 years) in a corresponding unilateral MPFLR cohort. We found a significant decrease in RTS rates for pediatric patients after bilateral MPFLR when compared with unilateral MPFLR (69% vs 94%; P = .03). Among those who returned to sports, there was no difference in the level of play achieved. For participants who did not RTS or returned at a lower level of play after bilateral MPFLR, 57% cited fear of reinjury as the primary reason. There were no differences in postoperative complications or current Single Assessment Numeric Evaluation scores between cohorts. The bilateral cohort had a significantly higher Caton-Deschamps index compared with the unilateral cohort, although the absolute difference was small (1.3 vs 1.2; P = .005). Conclusion: We found that pediatric patients have a lower RTS rate after bilateral MPFLR when compared with a matched unilateral MPFLR cohort. No differences in the level of play were achieved among those who returned to sports. Fear of reinjury was a commonly cited reason for not returning to sports.
Turkish validation of the chronic orchialgia symptom index and its association with the visual analog scale
Authors: Demirci Aykut , Hızlı Fatih , Başar Halil 
Published: April 2024

Objective: To conduct a translation and validation study of the Chronic Orchialgia Symptom Index (COSI), which has 12 questions in three domains pain (P), sexual symptoms (SS), and quality of life (QoL), in the Turkish language. Material and methods: The study included a total of 175 patients diagnosed with chronic scrotal content pain (CSCP) between January 2023 and January 2024. In addition to demographic data, the scores obtained on the COSI questionnaire and Visual Analog Scale (VAS) were recorded. Internal consistency was assessed using Cronbach alpha coefficients. Reliability was evaluated using the test-retest correlation method. Results: The mean age of the patients was 37.2 ± 14.1 years and the median (IQR) duration of pain was 5.5 (9) months. The median total COSI score was determined as 13 (13) and the median subscores were 7 (7) for P, 1 (2) for SS, and 5 (6) for QoL. The test-retest correlation coefficient for each item was determined to be higher than r = 0.80 ( p < 0.001). The Cronbach alpha values for the subscores were 0.80 for P, 0.71 for SS, and 0.80 for QoL. There was determined to be a statistically significant positive correlation between the VAS score and the COSI P, SS, QoL, and total scores ( r: 0.63, p < 0.001; r = 0.32, p < 0.001; r = 0.56, p < 0.001; r = 0.59, p < 0.001, respectively). The optimal cutoff point of the COSI total score was determined to be 16.5 points (AUC:0.77, p < 0.001) for the determination of patients experiencing severe pain (⩾ 7.5) according to the VAS score. Conclusion: The Turkish version of the COSI questionnaire is a valid, reliable, and repeatable questionnaire that can be used to evaluate the effects of symptom severity in patients with CSCP.
Les Youtubeuses : des actrices de la promotion du manger sain ? Une approche par les théories des pratiques
Authors: David Maxime , Dyen Margot , Ezan Pascale 
Published: April 2024

Résumé Les influenceurs qui s’expriment sur le manger sain jouissent d’une forte popularité. Cette recherche enrichit la compréhension de la mise en scène du quotidien à travers les vlog en décryptant les pratiques alimentaires mises en scène par les Youtubeuses, et en caractérisant les éléments constitutifs de ces pratiques. La recherche révèle que ces pratiques reposent sur des aliments-totems, des significations faisant écho aux préoccupations des followers (alimentation végétale, optimisation du temps), et des compétences au service de la simplicité et de l’efficacité. La proximité relationnelle et l’exemplarité (notamment physique) sont centrales dans les vidéos. Les résultats de l’article permettent de recommander comment les pouvoirs publics pourraient s’emparer de ces canons de la communication digitale, que l’on caractérise ici de communauté de pratiques.
Commentaire sur « Look up ! Cinq propositions de recherche pour repenser le marketing dans une société post-croissance » : contribution du Discours lacanien à un marketing plus responsable
Authors: Garnier Marion , Gotteland David 
Published: April 2024

Résumé Dans cet article, nous commentons la réflexion de Rémy et al. sur le marketing dans une société « post-croissance », où les partenaires de l’échange englobent l’ensemble des parties prenantes avec lesquelles l’organisation est en interaction, y compris son environnement naturel. Nous partageons l’idée de Rémy et al. que le marketing doit évoluer de manière radicale. Nous prolongeons leur point de vue en adoptant une perspective lacanienne. Selon Lacan, le discours est ce qui fait « lien social ». Nous proposons alors, à partir de la théorie lacanienne du discours, d’interroger ce que serait le discours d’un marketing responsable dans une société post-croissance et donc post-jouissance.
The Implementation of Tax Indirect Auditing Methods in Greek Economy Against Tax Evasion
Authors: Stasinopoulos Dionysios , Kastanioti Catherine 
Published: April 2024

This article aims to review and analyse the indirect auditing methods that were applied in Greece for the first time at the beginning of 2012 as a tax auditing tool, for the more comprehensive identification of taxable items. By employing the use of indirect auditing methods (mark-up method, net worth method, source and application of funds method, unit & volume method and bank deposits and cash expenditure method) an attempt is made to determine withheld taxable items, other than those measured by the tax forms and the official accounting books and taxpayers’ tax data, by utilizing the information from various sources and bodies. At the same time, a survey was carried out, on a randomly selected sample of 517 respondents, for analysing the awareness of Greek taxpayers regarding the use of indirect auditing methods as well as the general population’s awareness of their basic tax obligations. A total of 96.13% of the population were not aware of indirect audit methods while 79.88% expressed the belief that being aware of them can potentially increase citizens’ tax compliance. The survey highlighted that regarding indirect tax audit methods the level of knowledge of the general population is very low, necessitating the organized and systematic promotion of these new methods by the Tax Authority, which can lead to the disclosure of withheld (shadow) taxable items and thus achieve greater tax compliance in the long term.
Differentiation Syndrome Presenting as Acute Kidney Injury in a Patient of Acute Promyelocytic Leukemia on All-trans Retinoic Acid and Arsenic Trioxide Regimen: A Case Report
Authors: Dutta Madhurima , Das Tonmoy , Bora Mitul , Medhi Pranab , Choudhury Dhruvajyoti , Kakoti Sweety , Hazarika Tanurekha , Goswami Himanish , Bordoloi Zenila , Choudhury Sangeeta 
Published: April 2024

Introduction: Acute promyelocytic leukemia (APL), classified as Subtype M3 of acute myeloid leukemia, is known for its relatively favorable prognosis, primarily due to the high effectiveness of all-trans retinoic acid (ATRA) in treating the maturation block. However, it is essential to be aware of potential complications such as ATRA syndrome, which can affect 5%–25% of patients and manifest with symptoms such as fever, interstitial pulmonary infiltration, pleural/pericardial effusion, and acute renal failure. Methods: We present the case of a 47-year-old female with a history of hypertension, who experienced rash, fever, and reduced urine output during the induction phase with ATRA. Her serum creatinine levels exhibited a rapid increase from 2.63 mg/dL on October 07, 2022, to 7 mg/dL on October 18, 2022, despite having normal-sized kidneys and normal corticomedullary differentiation. A renal biopsy conducted on October 20, 2022, revealed features consistent with active tubulointerstitial nephritis, with direct immunofluorescence showing no significant glomerular immune deposits. A total of 17 hemodialysis sessions were performed. Results: A subsequent bone marrow examination conducted on October 26, 2022, demonstrated a hypercellular aspirate with normal morphology. However, due to the persistence of renal failure, a repeat biopsy was performed, revealing severe acute tubular injury. Pulse steroids were initiated, and ATRA was discontinued, resulting in an improvement in renal function. Conclusion: This case highlights an instance of acute, early, and severe differentiation syndrome (DS) occurring after induction therapy in a patient with APL. The DS in this case was particularly severe, leading to renal failure necessitating hemodialysis. The prompt initiation of pulse steroids and discontinuation of ATRA proved to be effective in managing this complication. Clinicians should remain vigilant for DS and its potential complications, including acute kidney injury and acute tubulointerstitial nephritis, when treating patients with APL.
Social Support Is Protective Against the Effects of Discrimination on Parental Mental Health Outcomes
Authors: Alvarez Dallis , Adynski Harry , Harris Rebeca , Zou Baiming , Taylor Jacquelyn Y. , Santos Hudson P. 
Published: April 2024

BACKGROUND: Discrimination, or unfair treatment based on individual characteristics such as gender, race, skin color, and or sexual orientation, is a pervasive social stressor that perpetuates health disparities by limiting social and economic opportunity and is associated with poor mental and physical health outcomes. AIMS: The purpose of the present study is to (1) examine the association between maternal experiences of discrimination and paternal experiences of discrimination; (2) explore how discrimination relates to parental (maternal and paternal) stress and depressive symptoms; and (3) examine whether social support exerts protective effects. METHODS: The sample was 2,510 mothers and 1,249 fathers from the Child Community Health Network study. Linear regression models were conducted to explore associations between maternal and paternal discrimination. In addition, mediation analyses were conducted to explore if social support functioned as a mediator between discrimination on parental stress and depressive symptoms. RESULTS: Most mothers (40.3%) and fathers (50.7%) identified race as the predominant reason for discrimination. Experiencing discrimination was significantly related to stress and depressive symptoms for both parents, and all forms of social support mediated these relationships. Our findings suggest that social support can act as a protective factor against the negative association between discrimination and both stress and depressive symptoms. CONCLUSIONS: These findings highlight the need to integrate social support into existing interventions and include fathers in mental health screenings in primary-care settings. Finally, we briefly describe the role of nurses and other allied health professionals in addressing discrimination in health care and health policy implications.
The need for more pragmatic trials in glaucoma research
Authors: Pacovska Mayara Fernanda , de Amorim-Cabral Camila Lisandra Dantas , Teixeira Eloisa Gomes do Rosário Monteiro , Kasahara Niro 
Published: April 2024

Aim There have been a number of clinical trials in glaucoma research published in the past two decades. Most of these trials were designed to evaluate very specific issues in selected populations placing them in the explanatory end of the pragmatic-explanatory continuum. The purpose of this study was to assess the level of pragmatism of published randomized controlled trials in glaucoma. Methods A PubMed search using ‘glaucoma’ from 1995 to 2022 and randomized controlled trial (RCT) article type was done. Each study was assessed by three independent examiners using the Pragmatic-Explanatory Continuum Indicator Summary version 2 (PRECIS-2) toolkit. Scores were calculated for each study to determine the level of pragmatism. A summed score ≥36 was indicative of a very pragmatic study. Results Thirty-two different articles were included in the analysis. These papers represented 13 different landmark trials. The median PRECIS-2 score was 32 (range, 25 for the Early Manifest Glaucoma Trial (EMGT) to 34 to the Collaborative Normal Tension Glaucoma Study (CNTGS) and the Ocular Hypertension Treatment Study). The Treatment of Advanced Glaucoma Study (TAGS), was considered very pragmatic and scored 33 points. Conclusion Despite the number of RCTs in glaucoma, there is still a need for more pragmatic studies.
Comparison of GATT versus micropulse transscleral diode laser cyclophotocoagulation combined with GATT in patients with advanced glaucoma
Authors: Karapapak Murat , Olgun Ali 
Published: April 2024

Purpose To compare the efficacy of gonioscopy-assisted transluminal trabeculotomy (GATT) versus micropulse transscleral diode laser cyclophotocoagulation(MP-TDLC) combined with GATT in the treatment of advanced glaucoma. Methods This retrospective comparative study study included 82 patients (82 eyes) with a diagnosis of advanced glaucoma: 36 patients underwent GATT, and 46 underwent GATT + MP-TDLC. Intraocular pressure (IOP) changes in patients who underwent GATT and GATT MP-TDLC were analyzed retrospectively at regular intervals during the 6-month follow-up period. Results For the 82 patients included in this study, the mean ± SD IOPs before the procedures were 27.2 ± 8.5 mmHg in the GATT group and 26.6 ± 6.9 mmHg in the GATT + MP-TDLC group ( p = 0.866), and the numbers of glaucoma medications used were 3.41 ± 0.5 in the GATT group and 3.36 ± 0.4 in the GATT + MP-TDLC group ( p = 0.605). The mean IOP after GATT was 13.6 ± 3.9 mmHg at day 1, 13.9 ± 3.7 mmHg at week 1, 14.6 ± 4.0 mmHg at month 1, 15.3 ± 4.3 mmHg at month 3, and 14.7 ± 3.3 mmHg at month 6. In the GATT + MP-TDLC group, the postoperative day 1, week 1, month 1, month 3, and month 6 IOP values were 12.4 ± 2.5, 11.8 ± 1.8, 12.1 ± 2.0, 11.8 ± 1.09, and 11.8 ± 1.5 mmHg, respectively. Conclusion GATT was found to be effective in the treatment of patients with advanced glaucoma, and results closer to the targeted low teens IOP values were obtained with GATT + MP-TDLC.
A rare case of simultaneous occurrence of non-arteritic anterior ischemic optic neuropathy and corpus callosum ischemia
Authors: Fossataro Federica , Pece Alfredo , Maione Giulio , Zur Dinah , Loewestein Anat 
Published: April 2024

Purpose To report a case of non-arteritic anterior ischemic optic neuropathy (NAION) in an elderly patient with ischemia of the left splenium of the corpus callosum, providing details of the diagnostic work-up and subsequent follow-up. Methods Section Case report. Results A pseudophakic 80 years-old woman referred complaining sudden visual impairment in the left eye (LE) in concomitance with episode of hypertensive crisis. Fundus examination showed diffuse swelling of optic disc associated with flame peripapillary hemorrhages in LE and small crowded disc in right eye (RE). A superior altitudinal defect with arcuate defect including the blind spot were detected at the visual field in the LE. The patient was diagnosed with NAION. Five days later the patient complained a further vision loss and a pathological area within the left splenium of corpus callosum, consistent ischemia, was depicted at magnetic resonance imaging of brain. Corpus callosum infarction was completely asymptomatic and neurological evaluation was normal. At 45 days follow-up fundus examination showed white ischemic nerve while visual field was irreversibly constricted with tubular defect in LE. Conclusion In case of NAION linked with corpus callosum ischemia multimodal imaging and systemic work-up play a pivotal role for an early diagnosis.