bluuebunny/crossref_metadata_2025_split huggingface dataset:
Voices on the Edge: Mental Health Status of Unemployed Adults of Working Age during the COVID-19 epidemic- A Retrospective Study Based on Data from the Psychological Assistance Hotline in HCM City
Authors: Wei Yating , Wu Deyuan , Chen Qiuxia , Fu Xiaonv , Song Haidong 
Published: April 2024

Abstract
OBJECTIVE: To investigate the utilization of psychological hotlines by the unemployed labor force during the COVID-19 epidemic and to explore their mental health status.
METHODS: General demographic data, types of caller problems and other information of unemployed adult labor force callers to the HCM City assistance hotline were collected from 2019 to 2022, and group comparisons were made according to different genders, different age groups, and caller times to understand the mental health status of this group by assessing depressive mood and suicide risk.Taking high-risk calls as outcome variables, multivariate Logistic regression was carried out to explore the related factors affecting the mental health status of this group.
RESULTS: A study of 6,297 cases found that males exhibited higher rates of major depression, suicidal ideation, planning, and behavior compared to females (P < 0.001). The youth group had significantly higher proportions of major depression and suicide risk compared to middle-aged and older individuals (P < 0.001). Calls in the second half of the night were associated with a higher proportion of callers reporting suicidal plans and preparations(P < 0.001). Young callers had an 11.04 times(OR=12.04,95%CI 3.523-41.148,P＜0.001)and senior callers had an 4.039 times (OR=5.039 95%CI 1.476-17.201,P=0.01) higher risk of suicidal behavior compared to middle-aged callers, and men were 1.211 times (OR=2.211 95%CI 1.423-3.435,P < 0.001)more likely to have high-risk calls than women. Gender and age were identified as influential factors for high-risk situations.
CONCLUSION: Unemployed callers who were male, in the youth group, and who called in the second half of the night had relatively poorer mental health and were at higher risk for suicide.
Proteomic analysis of sperm from fertile stallions and subfertile stallions due to impaired acrosomal exocytosis
Authors: Hernández-Avilés Camilo , Ramírez-Agámez Luisa , Weintraub Susan T. , Scoggin Charles F. , Davis Brian W. , Raudsepp Terje , Varner Dickson D. , Love Charles C. 
Published: April 2024

Abstract

Thoroughbred stallions that carry a double-homozygous genotype A/A-A/A for SNPs rs397316122 and rs69101140 in exon 5 of the FKBP6 gene (chr13; EquCab3.0) are uniquely subfertile due to impaired acrosomal exocytosis (IAE). In this study, the sperm proteome in frozen/thawed semen from subfertile Thoroughbred stallions was studied and compared to that of frozen/thawed sperm from fertile Thoroughbred stallions. A total of 2,220 proteins was identified, of which 140 proteins were found to be differentially abundant in sperm from the subfertile stallions when compared to that of fertile stallions (83 less and 57 more abundant). Proteins of differential abundance in sperm from the subfertile stallions were mostly overrepresented in the “metabolism” and the “metabolism of lipids” pathways. One of these proteins, arylsulfatase F (ARSF), was studied by immunofluorescence. A lower proportion of sperm displaying ARSF signal at the acrosome region was observed in sperm from subfertile Thoroughbred stallions. In addition, heterologous zona pellucida binding assays were performed and revealed sperm from subfertile Thoroughbred stallions bound at a lower proportion to zonae pellucidae than sperm from fertile Thoroughbred stallions. In conclusion, a group of proteins of differential abundance, including some of acrosome origin, were identified in sperm from subfertile stallions with acrosome dysfunction.
Unguarded refugees of deep waters: Flood vulnerability analysis of Kosi embankment through the lens of Hydro-geomorphological and Socio-economic parameters through GIS analysis
Authors: Devda Ajay , Verma Vishal , Jain Vikrant 
Published: April 2024

Abstract
The Kosi River basin is one of the most flood-affected regions in India. The first victims of these frequent floods are nearly 8 lakh people stranded between the Kosi river embankments in the Saharsa and Supaul districts of Bihar. These individuals face a trifecta of issues, including regular flooding, scarcity of basic amenities, and loss of livelihood, all of these are exacerbated by climate change impacts. The population living outside, too, had no respite due to frequent embankment breaches and waterlogging due to these structures. The region went through numerous flood-related research based on geomorphology, hydrology, and other physical factors; however, the flood impact assessment of embankments and its role within the socio-economic dimension remains unexplored. The present study unpacks flood vulnerability in 283 villages within the Kosi embankment. The study combines and analyzes thirteen attributes, including eight socio-economic and five hydro-geomorphic parameters, incorporating Sentinel-2, IMD, FMIS, and the 2011 census report and other survey reports. It employs GIS analysis to develop a socio-economic, hydro-geomorphic, and composite vulnerability map based on the weightage assigned to the aforementioned attributes. The analysis highlights that nearly the entire population in the embankment region is susceptible to the effects of flooding, with ∼66% of the region having high and very high flood risk and ∼26% in areas with moderate risk. The study’s outcomes could contribute to directing the effects and exclusion created by flood control infrastructure. They can also help to develop a comprehensive flood adaptation and resilience program for the Kosi River basin.
Formations effect of brass plate anode on electroplating thickness uniformity: case study on wheelchair headrest
Authors: Nurhadiyanto Didik , Kassyaf Khaerana Mutahara , Mujiyono  , Sasongko Beni Tri , Saputri Virda Hersy Lutviana 
Published: April 2024

Uniformity of coating thickness in the electroplating process of cylindrical objects using plate-shaped anodes has become a challenging issue. One electroplating method uses a cylindrical anode. However, this strategy is too expensive and requires a lot of material. This paper determines the effect of brass plate anode formation on the headrest thickness uniformity of the electroplating brass coating on the headrest connector of electric wheelchairs made of St. 37. The research started by making headrest connector using a turning machine, then plating the brass using the electroplating method, and then testing the thickness of the resulting brass for uniformity of data using statistics. The number and placement of the plate anodes varied with 2 symmetrical position anodes, 3 symmetrically spaced anodes, and 4 symmetrically positioned anodes. Coating thickness was measured using a digital microscope with a magnification of 200 times. Before measuring the thickness of the coating, the surface of the joint is milled first to remove any chamfer on the top surface of the body and the cover headrest connector. The surface is smoothed using sandpaper and cleaned using etching. Data from the uniformity test results show the highest level of uniformity in the variation of 4 anodes on the body and the cover of the headrest connector, followed by variations on the 3 anodes on the body and the cover of the headrest connector, and variations of 2 anodes on the body and the cover of the headrest connector. The greater the number of anodes and their placement around the cathode, the higher the thickness uniformity of the resulting brass electroplating layer. The formation of brass plate anode on electroplating affects headrest thickness uniformity
Outcomes of combined treatment of patients with acute lumbodynia
Authors: Barantsevich E. R. , Kamchatnov P. R. , Akhmadeeva L. R. 
Published: April 2024

Introduction. Acute dorsalgia is a common reason to seek outpatient medical care in Russia. The clinical picture usually includes muscular-tonic and pain syndromes. The most common form of dorsalgia by localization is acute lumbar pain (lumbodynia).Aim. To evaluate the effectiveness of Spascuprel®, Traumeel S in the complex treatment of patients with acute lumbar pain in real-world clinical practice.Materials and methods. We conducted a non-interventional, prospective, observational study of 110 outpatients aged 26 to 65 years. Patients received a standard on-demand therapy with nonsteroidal anti-inflammatory drugs (NSAIDs). In addition, Group 1 received Spascuprel® and Traumeel® C, and Group 2 received centrally acting muscle relaxants. The effectiveness of treatment was assessed using the visual analogue scale (VAS) of pain intensity and the limitations of various activities in daily living were measured using the Roland – Morris questionnaire. Consideration was given to the exacerbation duration, the need for additional intake of NSAIDs, and the number of cases of pain exacerbation within 60 days from the start of participation in the observational study.Results. Under treatment, pain intensity showed statistically significant decreases in VAS scores (from 61.0 to 35.5 scores out of 100 according to VAS by Day 7 and to 19.5 scores by Day 14 of treatment in Group 1, from 61.2 to 41.1 and to 25.8 scores in Group 2, respectively (p < 0.05)). A more rapid decrease was observed in VAS pain intensity score from baseline in Group 1. Over 2-month observation period, group 1 had less exacerbations (p < 0.05) and fewer cases of need for additional intake of NSAIDs (p < 0.05). The frequency and severity of adverse events did not differ between two groups.Conclusion. A more rapid decrease in VAS pain intensity scores and reduction in the need for NSAIDs were noted in the group of patients with acute dorsalgia who used Traumeel® C and Spascuprel® in addition to standard NSAID therapy.
Impact of cumulus parameterization schemes on summer extreme precipitation simulation in the Yellow River Basin: the 2018 case
Authors: Chen Shihao , Lv Xing , Men Baohui 
Published: April 2024

ABSTRACT

This study uses the Weather Research and Forecasting (WRF) model with five different cumulus parameterization schemes (CPSs) at a resolution of 30 km to simulate the summer (June, July, and August) extreme precipitation event in the Yellow River Basin (YRB) during 2018. The goal of this study is to investigate the sensitivity of extreme precipitation simulation in the YRB during the summer of 2018 to CPSs in the WRF model. The results show that all five CPSs were capable of approximately simulating the direction of the rain bands in the YRB during the summer of 2018, but the simulation results of all CPSs tended to overestimate the value of precipitation amount. Upon further evaluation using seven different methods, it was found that the Betts–Miller–Janjic scheme provided the best simulation of this event. The complex orography of the YRB has a significant influence on moisture transport. The WRF model may have overestimated the moisture flux, which could have contributed to the overestimation of precipitation. The summer extreme precipitation event in the YRB during 2018 may have been influenced by an influx of excessive moisture from the western boundary.
Experimental investigation on a new method for modifying the geometry of a vertical drop edge equipped with a screen on the amount of energy dissipation
Authors: Daneshfaraz Rasoul , Norouzi Reza , Abar Maryam 
Published: April 2024

Abstract

The aim of the current research is to investigate the effect of geometry and different angles (180°, 150°, 120° and 90°) of the edge of a vertical drop with a height of 0.15 m with and without a vertical screen on energy dissipation. The finding showed that the triangulation plane forms a vertical drop at different angles of 180°, 150°, 120° and 90° without a screen that increases the energy dissipation of the drop, which is highest at an angle of 90°, by 50.5%. In the vertical drop with a screen, reducing the angle also leads to a decrease in energy dissipation, so the highest energy dissipation occurs at an angle of 180° with a 45.2% increase in energy dissipation compared to the vertical drop without a screen. The relative depth of the edge and the relative depth of the vertical drop pool of the triangular plane are different at the angle vertex and its wings, in such a way that the relative depth of the edge at the vertex is less than the wings and the relative depth of the pool at the vertex is greater than the wings.
The Effects of Curcumin Plus Piperine Co-administration on Inflammation and Oxidative Stress: A Systematic Review and Meta-analysis of Randomized Controlled Trials
Authors: Hosseini Hossein , Ghavidel Farideh , Rajabian Arezoo , Homayouni-Tabrizi Masoud , Majeed Muhammed , Sahebkar Amirhossein 
Published: April 2024

Background:
The beneficial effects of curcumin against various chronic disorders
have been shown in the last few decades. However, due to its low bioavailability,
therapeutic effects are less than expected. Piperine has been used in scientific evaluations
as an effective compound to increase the bioavailability of curcumin. The present
review investigated the impact of curcumin plus piperine intake on oxidative stress and
inflammatory markers of Randomized Clinical Trials (RCTs).

Methods:
Using relevant keywords, we searched Cochrane Library, Scopus, PubMed,
and Web of Science between January 1st, 1970, and September 30th, 2022. A comprehensive
search for RCTs was performed. Continuous data were pooled by Standard Mean
Difference (SMD) and 95% confidence interval. All related statistical analyses were performed
using Comprehensive Meta-Analysis (CMA) software.

Results:
A total of 13 articles were incorporated into the final meta-analysis. According
to the current meta-analysis, curcumin plus piperine administration showed a significantly
increased SOD activity and GSH levels while significantly decreased MDA concentrations.
In addition, our study revealed that curcumin plus piperine significantly decreased
TNF-α and IL-6 concentrations.

Conclusion:
These results indicated that curcumin plus piperine administration could effectively
reduce oxidative stress and inflammation.
Zamzam Water Mitigates Cardiac Toxicity Risk through Modulation of GUT
Microbiota and the Renin-angiotensin System
Authors: Sheikh Ryan Adnan , Nadem Mohammad Shahid , Asar Turky Omar , Almujtaba Mohammed A. , Naqvi Salma , Al-Abbasi Fahad A. , Almalki Naif Abdullah R. , Kumar Vikas , Anwar Firoz 
Published: April 2024

Background:
Cardiovascular diseases (CVDs) continue to exert a substantial global influence in
specific areas due to population growth, aging, microbiota, and genetic/environmental factors. Drinking water
has a strong impact on the health of an individual. Further, emerging evidence has highlighted the therapeutic
potential and benefits of Zamzam water (Zam).

Objective:
We investigated the influence of Zam on doxorubicin-induced cardiac toxicity, elucidating its consequential
effects on GUT microbiota dysbiosis and hepatic and renal functions.

Methods:
Male rats were categorized into four groups: Group 1 as Normal control (NC), Group 2 as Zamzam
control (ZC), Group 3 Disease control (DC) and Group 4 as Therapeutic control (DZ) treated with Zam
against doxorubicin-induced disease at a dose of 1mg/kg boy weight) intraperitoneally (i.p).

Results:
Significant dysbiosis in the composition of GM was observed in the DC group along with a significant
decrease (p < 0.05) in serum levels of Zinc, interleukin-10 (IL-10), IL-6 and Angiotensin II (Ang II),
while C-reactive protein (CRP), fibrinogen, and CKMB increased significantly (restoration of Zinc ions (0.72
± 0.07 mcg/mL) compared to NC. Treatment with Zamzam exhibited a marked abundance of 18-times to 72%
in Romboutsia, a genus of firmicutes, along with lowering of Proteobacteria in DZ followed by significant
restoration of Zinc ions (0.72 ± 0.07 mcg/mL), significant (p ˂ 0.05) reduction in CRP (7.22 ± 0.39 mg/dL),
CKMB (118.8 ± 1.02 U/L) and Fibrinogen (3.18 ± 0.16 mg/dL), significant (p < 0.05) increase in IL-10 (7.22
± 0.84 pg/mL) and IL-6 (7.18 ± 0.40 pg/ml), restoration of Ang II (18.62 ± 0.50 nmol/mL/min), marked increase
in renin with normal myocyte architecture and tissue orientation of kidney, and restoration of histological
architecture of hepatocyte.

Conclusion:
Zam treatment mitigated cardiac toxicity risk through the modulation of GUT microbiota and the
renin-angiotensin system and tissue histology effectively.
Protective Effects of Curcumin and Nanomicelle Curcumin on Chlorpyrifos-induced Oxidative Damage and Inflammation in the Uterus, Ovary and Brain of Rats
Authors: Nazarian Maryam , Aramjoo Hamed , Roshanravan Babak , Samarghandian Saeed , Farkhondeh Tahereh 
Published: April 2024

Background and Aims:
Chlorpyrifos (CPF), which is classified as an Organophosphorus
Pesticide (OP), has been identified as a toxic agent for the reproductive system due to its capacity
to induce oxidative stress and inflammation. Curcumin (CUR) has been reported as a natural
antioxidant and anti-inflammatory agent that could combat toxicity in various tissues. This
study aims to examine the protective effects of CUR and its nanoformulation against reproductive
impairment induced by CPF.

Methods:
Forty-eight female Wistar albino rats were randomly allocated to six groups (n=8):
control (0.5 mL of corn oil, the solvent for CPF), CPF (10 mg/kg), CPF + CUR 100 mg/kg/day,
CPF + CUR 300 mg/kg/day, CPF + nano-micelle curcumin (NMC) 2.5 mg/kg/day, and CPF +
NMC 5 mg/kg/day. The experimental treatment was performed for 30 days. Then, brain, ovary
and uterus tissues were collected for measuring oxidative stress and inflammatory indices.

Results:
MDA, NO, IL-6, and TNF-α concentrations significantly increased in the brain, ovary
and uterus of the CPF group versus the control group (p < 0.001). The levels of GSH and SOD in
the uterus, ovaries, and brain exhibited a significant decrease in the CPF group compared to the
control group (p < 0.05). However, CUR (300 mg/kg) and NMC (5 mg/kg) significantly decreased
MDA, NO, TNF-α, and Il-6 and increased SOD and GSH levels in the uterus, ovaries and
brain of the CPF-exposed animals versus the CPF-exposed non-treated animals (p < 0.001).

Conclusion:
Our findings indicated that CUR and NMC could be effective in alleviating CPFinduced
reproductive toxicity.
A Review of the Common Neurodegenerative Disorders: Current
Therapeutic Approaches and the Potential Role of Bioactive Peptides
Authors: Singh Kuldeep , Gupta Jeetendra Kumar , Kumar Shivendra , Soni Urvashi 
Published: April 2024

Abstract::
Neurodegenerative disorders, which include Alzheimer's disease (AD), Parkinson's disease
(PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS), represent a significant
and growing global health challenge. Current therapies predominantly focus on symptom management
rather than altering disease progression. In this review, we discuss the major therapeutic
strategies in practice for these disorders, highlighting their limitations. For AD, the mainstay treatments
are cholinesterase inhibitors and N-methyl-D-aspartate (NMDA) receptor antagonists. For
PD, dopamine replacement therapies, including levodopa, are commonly used. HD is managed primarily
with symptomatic treatments, and reusable extends survival in ALS. However, none of these
therapies halts or substantially slows the neurodegenerative process. In contrast, this review
highlights emerging research into bioactive peptides as potential therapeutic agents. These naturally
occurring or synthetically designed molecules can interact with specific cellular targets, potentially
modulating disease processes. Preclinical studies suggest that bioactive peptides may mitigate
oxidative stress, inflammation, and protein misfolding, which are common pathological features
in neurodegenerative diseases. Clinical trials using bioactive peptides for neurodegeneration
are limited but show promising initial results. For instance, hemiacetal, a γ-secretase inhibitor peptide,
has shown potential in AD by reducing amyloid-beta production, though its development was
discontinued due to side effects. Despite these advancements, many challenges remain, including
identifying optimal peptides, confirming their mechanisms of action, and overcoming obstacles related
to their delivery to the brain. Future research should prioritize the discovery and development
of novel bioactive peptides and improve our understanding of their pharmacokinetics and
pharmacodynamics. Ultimately, this approach may lead to more effective therapies for neurodegenerative
disorders, moving beyond symptom management to potentially modify the course of these
devastating diseases.
Research Progress on Extracellular Matrix Involved in the Development
of Preeclampsia
Authors: Wang Xin , Zhang Qi , Ren Yi , Liu Chao , Gao Huijie 
Published: April 2024

Abstract::
Preeclampsia (PE) is a serious pregnancy complication, and its primary clinical manifestations
are gestational hypertension and proteinuria. Trophoblasts are responsible for the basic
functions of the placenta during placental development; recent studies have revealed that placental
“shallow implantation” caused by the decreased invasiveness of placental trophoblasts plays a crucial
role in PE pathogenesis. The interaction between the cells and the extracellular matrix (ECM)
plays a crucial role in trophoblast proliferation, differentiation, and invasion. Abnormal ECM function
can result in insufficient migration and invasion of placental trophoblasts, thus participating
in PE. This article summarizes the recent studies on the involvement of ECM components, including
small leucine-rich proteoglycans, syndecans, glypicans, laminins, fibronectin, collagen, and
hyaluronic acid, in the development of PE. ECM plays various roles in PE development, most
notably by controlling the activities of trophoblasts. The ECM is structurally stable and can serve
as a biological diagnostic marker and therapeutic target for PE.
Review Deciphering the Potential of Nanotherapeutics in Lung Cancer Management
Authors: Chauhan Prashant , Pandey Pratibha , Ramniwas Seema , Khan Fahad 
Published: April 2024

Abstract::
Lung cancer remains a formidable challenge in oncology, necessitating the develop-ment of more effective prognostic and diagnostic techniques due to inefficient conventional therapeutic approaches and inadequate methods for early lung cancer diagnosis. Despite im-mense progress in the development of innovative strategies to alleviate the impact of this devas-tating disease, the outcomes, unfortunately, remain unsatisfactory, particularly in targeted drug delivery methods. Consequently, nanotechnology has emerged as a revolutionary force in cancer research to develop more effective targeted drug delivery tools due to its extraordinary capacity at the atomic and molecular levels. It has appeared as a beacon of hope in this area of unmet need, providing innovative ways for the prognosis and diagnosis of lung carcinoma. Therefore, this comprehensive review delves into the evolving field of nano-based therapeutics, shedding light on their potential to transform lung cancer treatment. This study meticulously explores the most promising nano-based strategies that have been extensively linked with the treatment of lung carcinoma and mainly emphasizes targeted drug delivery methods and therapies. Addition-ally, this review encapsulates the favorable results of clinical trials, which support the potential pathways for further development of nanotherapeutics in lung cancer management