bluuebunny/crossref_metadata_2025_split huggingface dataset:
Autotransplantation of an impacted migrated mandibular canine using platelet-rich fibrin and physio-dispenser system: a report of two cases
Authors: Shetty Rajmohan , Shetty Vabitha , Aswath Nikhitha , Rai Kavitha 
Published: March 2024

Canine impaction and migration is conventionally managed by fixed orthodontic treatment with surgical exposure; however this is not always possible, thus requiring clinicians to explore other treatment options. Autotransplantation of the tooth has been recognized as an alternative treatment option. This article reports on two cases where a migrated canine was asymptomatic, and accidentally diagnosed during routine examination. The procedure undertaken was autotransplantation of the canine using a physio-dispenser system and a platelet-rich fibrin (PRF) membrane to promote bone and soft tissue healing and regeneration. After a 2-year follow up, the autotransplanted canines showed no signs or symptoms of clinical or radiological failure. On radiographic examination, a patent periodontal ligament space was also appreciated. CPD/Clinical Relevance: Use of a physio-dispenser system and PRF during autotransplantation of a migrated and impacted canine may improve the clinical outcome.
Digital Zombies, Undead Stories: Narrative Emergence and Videogames, Lawrence May (2021)
Authors: Kirkland Ewan 
Published: March 2024

Review of: Digital Zombies, Undead Stories: Narrative Emergence and Videogames, Lawrence May (2021)
London: Bloomsbury Academic, 264 pp.,
ISBN 978-1-50136-354-2, h/bk, AUD 162
ISBN 978-1-50137-487-6, p/bk, AUD 53.99
ISBN 978-1-50136-354-9, e-book, AUD 43.19
Resolution of Severe Portopulmonary Hypertension With Inhaled Treprostinil and Liver Transplantation
Authors: Chang Alex J. , Goh Choon Hwa 
Published: March 2024

Abstract
Portopulmonary hypertension is a rare condition with a poor prognosis. Prompt management is essential for liver transplantation eligibility, a potentially curative option. This report presents a case of severe portopulmonary hypertension that resolved with a conservative therapeutic regimen of tadalafil, macitentan, and inhaled treprostinil, which ultimately enabled successful liver transplantation. There was no recurrence of pulmonary hypertension after transplantation, and the patient was weaned off most pulmonary arterial hypertension therapies. This case report is the first to provide evidence that inhaled treprostinil is a safe and effective alternative to continuous intravenous prostacyclins in portopulmonary hypertension.
Infinitely many free or prescribed mass solutions for fractional Hartree equations and Pohozaev identities
Authors: Cingolani Silvia , Gallo Marco , Tanaka Kazunaga 
Published: March 2024

Abstract
In this paper we study the following nonlinear fractional Hartree (or Choquard-Pekar) equation

(

−
Δ

)

s

u
+
μ
u
=

(

I

α

*
F

(

u

)

)

F

′

(

u

)

in

R

N

,

${\left(-{\Delta}\right)}^{s}u+\mu u=\left({I}_{\alpha }{\ast}F\left(u\right)\right){F}^{\prime }\left(u\right)\quad \text{in} {\mathbb{R}}^{N},$

(*) where μ > 0, s ∈ (0, 1), N ≥ 2, α ∈ (0, N),

I

α

∼

1

|
x

|

N
−
α

${I}_{\alpha }\sim \frac{1}{\vert x{\vert }^{N-\alpha }}$

is the Riesz potential, and F is a general subcritical nonlinearity. The goal is to prove existence of multiple (radially symmetric) solutions

u
∈

H

s

(

R

N

)

$u\in {H}^{s}\left({\mathbb{R}}^{N}\right)$

, by assuming F odd or even: we consider both the case μ > 0 fixed and the case

∫

R

N

u

2

=
m
>
0

${\int }_{{\mathbb{R}}^{N}}{u}^{2}=m{ >}0$

prescribed. Here we also simplify some arguments developed for s = 1 (S. Cingolani, M. Gallo, and K. Tanaka, “Multiple solutions for the nonlinear Choquard equation with even or odd nonlinearities,” Calc. Var. Partial Differ. Equ., vol. 61, no. 68, p. 34, 2022). A key point in the proof is given by the research of suitable multidimensional odd paths, which was done in the local case by Berestycki and Lions (H. Berestycki and P.-L. Lions, “Nonlinear scalar field equations II: existence of infinitely many solutions,” Arch. Ration. Mech. Anal., vol. 82, no. 4, pp. 347–375, 1983); for (*) the nonlocalities play indeed a special role. In particular, some properties of these paths are needed in the asymptotic study (as μ varies) of the mountain pass values of the unconstrained problem, then exploited to describe the geometry of the constrained problem and detect infinitely many normalized solutions for any m > 0. The found solutions satisfy in addition a Pohozaev identity: in this paper we further investigate the validity of this identity for solutions of doubly nonlocal equations under a C
1-regularity.
Heteronomie und Entfremdung
Authors: Rivero Gabriel 
Published: March 2024

Abstract
New approaches to the concept of alienation propose to understand alienation as a kind of heteronomy and to establish a connection between Kant’s and Marx’ philosophy. This paper explores Kant’s understanding of alienation and shows, with help of Kant’s Reflexionen, that he exclusively conceives the term “entfremden/Entfremdung” within the meaning of the legal concept of “Veräußerung”. When interpreting “Entfremdung” as “Veräußerung” instead of “heteronomy”, similarities emerge between Kant’s and Marx’ thought, which manifest in the Kantian figure of the locator and the Marxian worker.
Experimental investigation on strengthening lap joints subjected to bending in glulam timber beams using CFRP sheets
Authors: Al-Tameemi Haider Ali , Al-Katib Haider A. A. , Alkhudery Hayder H. 
Published: March 2024

Abstract
Strengthening the carpentry joints is considered a big challenge for designers to maintain the joined timber elements’ load transfer and integrity. This research work investigates different techniques to strengthen the lap joints in glulam timber beams using carbon fiber-reinforced polymer (CFRP) sheets. For this purpose, 12 specimens of glulam timber beams were tested using the four-point loading method. One of the glulam timber specimens was an intact nonlapped specimen, and the others were lapped at mid-span using half-height lap joints. The lap joints were strengthened using different configurations of the CFRP sheets. The test variables were the clamping scheme, bond length, and reinforcement ratio of the CFRP sheets. The analysis of the test results indicates that the CFRP strengthening configuration could be more effective in strengthening the lapped glulam timber beams when the reinforcement ratio of the longitudinal CFRP sheets was equal to 0.303%, and the wrapping CFRP sheets continued beyond the lapped joint by a distance equal to the beam height. Such a strengthening configuration could succeed in increasing the effective stiffness and ultimate load of the lapped timber specimen to 109 and 110%, respectively, relative to those of the intact nonlapped specimen. Moreover, the results reveal that increasing the length or the reinforcement ratio of the longitudinal CFRP sheets without increasing the width of the wrapping CFRP sheets could not succeed in achieving the required improvements in the structural behavior of the lapped timber beams.
Cinnamic acid, a natural plant compound, exhibits neuroprotection in a mouse model of Sandhoff disease via PPARα
Authors: Raha Sumita , Paidi Ramesh K. , Dutta Debashis , Pahan Kalipada 
Published: March 2024

Abstract
Tay-Sachs disease (TSD) and its severe form Sandhoff disease (SD) are autosomal recessive lysosomal storage metabolic disorders, which often result into excessive GM2 ganglioside accumulation predominantly in lysosomes of nerve cells. Although patients with these diseases appear normal at birth, the progressive accumulation of undegraded GM2 gangliosides in neurons leads to early death accompanied by manifestation of motor difficulties and gradual loss of behavioral skills. Unfortunately, there is still no effective treatment available for TSD/SD. The present study highlights the importance of cinnamic acid (CA), a naturally occurring aromatic fatty acid present in a number of plants, in inhibiting the disease process in a transgenic mouse model of SD. Oral administration of CA significantly attenuated glial activation and inflammation and reduced the accumulation of GM2 gangliosides/glycoconjugates in the cerebral cortex of Sandhoff mice. Besides, oral CA also improved behavioral performance and increased the survival of Sandhoff mice. While assessing the mechanism, we found that oral administration of CA increased the level of peroxisome proliferator-activated receptor α (PPARα) in the brain of Sandhoff mice and that oral CA remained unable to reduce glycoconjugates, improve behavior and increase survival in Sandhoff mice lacking PPARα. Our results indicate a beneficial function of CA that utilizes a PPARα-dependent mechanism to halt the progression of SD and thereby increase the longevity of Sandhoff mice.
Analysis of water absorption on the efficiency of bonded composite repair of aluminum alloy panels
Authors: Ahmed Faraz , Mhamdia Rachid , Mohammed Sohail M. A. K. , Benyahia Faycal , Albedah Abdulmohsen , Bachir Bouiadjra Bel Abbes 
Published: March 2024

Abstract
Carbon fiber-reinforced polymer (CFRP) exhibits aging effects over time that can degrade its mechanical properties. In this study, a systematic investigation was carried out to investigate the effect of distilled water aging on the mechanical properties of CFRP composite patch bonded on Al 2024-T3 plates. We built a finite element model to analyze the effect of water absorption by the composite and the adhesive on the effectiveness of the composite patch repair. Using the experimentally evaluated mechanical properties of CFRP and Araldite adhesive subjected to distilled water immersion, finite element simulations were validated. The experimental observations deduce that there was a negligible effect of moisture absorption on the bulk mechanical properties of CFRP and adhesive over time. However, a significant effect of moisture absorption was observed on the elasto-plastic behavior of both CFRP and adhesive. Consequently, the numerical simulations suggest that the moisture absorption reduces the bonded composite patch repair efficiency attributed to an increase in the plasticity around the crack front and accordingly increases the damage in the adhesive layer. This study attempts to provide guidelines on the severity of damage caused by water absorption on the performance of structures repaired with composite patches.
Early exercise intervention promotes myelin repair in the brains of ischemic rats by inhibiting the MEK/ERK pathway
Authors: Wang Junyi , Ding Xinyu , Li Chen , Huang Chuan , Ke Changkai , Xu Chunlei , Wan Chunxiao 
Published: March 2024

Abstract
Our previous studies have shown that early exercise intervention after stroke increases neural activity and synaptic plasticity and promotes the recovery of nerve fiber bundle integrity in the brain. However, the effect of exercise on the repair of myelin in the brain and the related mechanism are still unclear. In this study, we randomly divided the rats into three groups. Before and after 28 days of intervention, body weight, nerve function, the infarct size, white matter fiber bundle integrity, and nerve myelin structure and function were observed by measuring body weight, analysis of modified neurological severity score, CatWalk gait analysis, MRI, luxol fast blue staining, immunofluorescence, and transmission electron microscopy. Changes in the expression of proteins in the MEK/ERK pathway were assessed. The results showed that early exercise intervention resulted in neurological recovery, decreased the infarct volume and increased nerve fiber integrity, the myelin coverage area, myelin basic protein (MBP) fluorescence intensity expression, and myelin thickness. Furthermore, the expression level of MBP was significantly increased after early exercise intervention, while the expression levels of p-MEK1/2 and p-ERK1/2 were significantly reduced. In the cell study, MBP expression levels were significantly higher in the oxygen and glucose deprivation and administration group.In summary, early exercise intervention after stroke can promote myelin repair by inhibiting the MEK/ERK signaling pathway.
“Cassius Dio, A Bithynian ‘exiled’ to Rome?”
Authors: Freyburger-Galland Marie-Laure 
Published: March 2024

AbstractFirst, we will retrace the life and brilliant career of this Roman senator of Bithynian origins who came from an ancient family of public figures and who had served five or six emperors and been friends with several of them, having been twice appointed to the role of consul.Then we will consider the nature of his role as Senator coming from an Eastern province and its relationship with Roman power. We will come to see that he represents the perfect example of his theory of the association of provincial élites coming to power, which was developed at length in his work, Roman History, which he produced in Greek for a Greek readership.Finally, rather paradoxically, we will consider how he sees himself in a largely bi-lingual and bi-cultural empire and how he speaks of his homeland with a view to determining whether his attachment to his ‘little country’ is the stronger and if his numerous sojourns in Rome amount to little more than a ‘golden exile’ for him.
Spatial and spiritual exile in Vergil's Aeneid
Authors: Walker Henry John 
Published: March 2024

AbstractFor Homer, Cicero, and Ovid, exile is equivalent to death, or even worse. Vergil's Aeneas is torn between his old homeland of Troy and the new home he must create in Italy, but he overcomes his nostalgia. Aeneas is consoled by the Stoic doctrine that he is obeying Fate, which governs the entire world, and by the Cynic view that he can carry his true self and identity with him anywhere he goes. In Book 6 of the Aeneid, he is given a revelation about reincarnation that is based on the Republics of Plato and Cicero. This teaching that all of life is an exile from heaven contrasts sharply with the worldly mission of conquest that Aeneas must follow in Italy. Vergil's sympathies lie with the exile rather than the conqueror.
Clonal dissemination of Acinetobacter radioresistens among Humboldt penguins (Spheniscus humboldti) inhabiting a barren northern Peruvian island
Authors: Roca Ignasi , Espinoza Kathya , Irigoin-Lovera Cinthia , Piquet Maria , Palomino-Kobayashi Luciano A. , Castillo Angie K. , Gonzales-DelCarpio Diego D. , Viñes Joaquim , Muñoz Laura , Ymaña Barbara , Oporto Rosario , Zavalaga Carlos , Pons Maria J. , Ruiz Joaquim 
Published: March 2024

AbstractAcinetobacter spp. are often isolated from natural sources, but knowledge about their presence in wild animals is fragmented and uncomplete. The present study aimed to characterize a series of Acinetobacter radioresistens isolated from Humboldt penguins (Spheniscus humboldti). Fifteen Humboldt penguins from an inhabited northern Peruvian island were sampled. Microorganisms were identified by MALDI-TOF MS. Antibiotic susceptibility to 12 antimicrobial agents was established, and clonal relationships were determined. A representative isolate was selected for whole genome sequencing (WGS). A. radioresistens were isolated from the feces of 12 (80%) Humboldt penguins, being susceptible to all the antimicrobial agents tested, except eight cefotaxime-intermediate isolates. All A. radioresistens were clonally related. WGS showed that the isolate belonged to ST1972, the presence of two chromosomal encoded carbapenemases (blaOXA-23 and a putative subclass B3 metallo-β-lactamase), and a series of point mutations in antibiotic-resistance related chromosomal genes, which were considered as polymorphisms. In addition, a few virulence factors, including a capsule-encoding operon, superoxide dismutases, catalases, phospholipases and a siderophore receptor were identified. The present results suggest that A. radioresistens may be a common member of the gut microbiota of Humboldt penguins, but further studies in other geographical areas are needed to establish this finding.
A prática docente e a educação CTS: reflexões a partir do tema agrotóxicos
Authors: Kist Daiane , München Sinara 
Published: March 2024

Este artigo de pesquisa tem como foco a prática docente a partir de uma proposta didática sobre o tema agrotóxicos, desenvolvida na disciplina de Química em uma turma de terceiro ano do Ensino Médio, pautada nos pressupostos da Educação CTS (Ciência-Tecnologia-Sociedade). O tema, considerado controverso, estava relacionado ao contexto dos estudantes. Desta forma, a análise objetivou identificar as implicações, desafios e potencialidades no e para o ensino de Ciências. A abordagem metodológica é qualitativa, partindo da análise do diário de bordo, produzido no decorrer das aulas. Os excertos foram analisados de acordo com a Análise Textual Discursiva, emergindo uma categoria final intitulada: Reflexões sobre a prática docente frente a Educação CTS. Os resultados contribuem para evidenciar o ato de refletir sobre o que se deve ensinar e o que se ensina, promovendo debates voltados para o contexto que objetivam a formação de cidadãos críticos, do mesmo modo que auxilia positivamente na constituição do professor. Dentre os resultados destaca-se a falta de tempo dos professores, condições e ferramentas para promover o ensino de forma interdisciplinar e, ainda, a falta de formação inicial e/ou continuada pautada nos pressupostos da Educação CTS. Assim, as potencialidades se referem às modificações na prática docente, identificadas neste trabalho, sendo oriundas de reflexões e vivências de atividades em sala de aula a partir da Educação CTS.
A study evaluating and comparing the effectiveness of combination therapy – Duloxetine with darifenacin versus darifenacin as monotherapy on perception of symptoms, quality and standard of life in patients suffering with overactive bladder (OAB)
Authors: Goel Nidhi , Prakash Ved , Giri Kiran R , Dehade Amol 
Published: March 2024

: Overactive bladder is chronic debilitating condition, with physical, psychological, and economical consequences. Urinary vesicle tissue contains muscarinic receptors, M3 is principal mediator of detrusor contraction. Muscarinic receptor antagonists, comprises traditional pharmacological treatment. But due to non-selective inhibition, these agents, probably been related with safety and tolerability concerns. Drugs particular inhibiting sM3 receptor (Darifenacin) have potential to present effective relief while reducing side effects concerned with blockade of M1, M2 and M5 receptors. Duloxetine is Serotonin and nor-epinephrine reuptake inhibitor, leading increased concentration of 5-HT and NE in synaptic cleft, increases stimulation of pudendal motor neurons, thus increasing resting tone and contraction of urethral sphincter.: In present prospective, randomized, parallel group, comparative open label study with 60 OAB patients the combination therapy of Duloxetine with Darifenacin was equated with monotherapy using Darifenacin. The outcome thus analyzed using three different OAB-questionnaires and was statistically compared. : We demonstrated that addition of Duloxetine has shown better result outcome in symptoms as well as quality of life, though the difference of OAB-V8, OABss mean score was non-significant, but for OAB-qSF the reduction (percentage change) in mean score was more in treatment group II as compare to group I (w6:13.82±3.17% vs 12.13±3.24% & W12 29.99±5.40% Vs 25.56±5.17%) , and was statistically significant.(p&#60;0.05).: Duloxetine has synergistic effect to Darifenacin, its ability to increase bladder capacity may be the reason for the improvement OAB symptoms, promising in controlling and treating symptoms either alone or in combination with anti-cholinergic drugs.
Hubungan Kadar Serum Glutamic Pyruvate Transaminase (SGPT) dan Serum Glutamic Oxaloacetic Transaminasi (SGOT) dengan Riwayat Konsumsi Alkohol Pada Etnis Papua
Authors: Azizi Biesta Adri , Nurhantari Yudha , . Suhartini , . Triratnaningsih 
Published: March 2024

Tujuan penelitian ini adalah untuk mengetahui hubungan kadar SGPT dan SGOT dengan riwayat konsumsi alkohol pada etnis Papua Penelitian ini merupakan penelitian deskriptif analitik untuk mengetahui adanya hubungan antara riwayat konsumsi alkohol dengan kadar SGPT dan SGOT. Desain penelitian ini adalah cross sectional dan melibatkan 29 responden etnis Papua yang berdomisili di Yogyakarta. Sampel adalah darah yang didapatkan dari responden setelah dilakukan anamnesis, untuk diperiksa kadar SGPT dan SGOT. Analisis dilakukan menggunakan uji statistik chi-square dengan uji alternatif, Fisher’s exact test. Dari hasil analisis yang telah dilakukan menggunakan uji statistik chi-square, maka didapatkan bahwa tidak ada hubungan yang signifikan secara statistik (p > 0.05) antara kadar SGPT dan SGOT yang diperiksa dengan riwayat konsumsi alkohol pada etnis Papua. Tidak terdapat perbedaan proporsi yang bermakna antara individu etnis Papua yang memiliki riwayat konsumsi alkohol dan individu etnis Papua yang tidak memiliki riwayat konsumsi alkohol terhadap kadar SGPT dan SGOT, namun memiliki kecenderungan peningkatan kadar SGOT 2.567 kali lebih besar dibandingkan individu yang tidak memiliki riwayat konsumsi alkohol.
KARAKTERISTIK KONDISI KESEHATAN PADA PASIEN KORBAN TINDAK PIDANA PERDAGANGAN ORANG: TINJAUAN LITERATUR SISTEMATIS
Authors: Gizela Beta Ahlam , Puspitasari Kintan 
Published: March 2024

Background: Human trafficking is a crime that degrades human dignity, involving hundreds or even thousands of victims per year both on a global and local scale. In the human trafficking, various types of violence often occur. It is important to identify that the patient is a victim of human trafficking when a doctor encounter a patient due to sexual violence. Doctor must pay more attention to collect evidence through anamnesis, physical examination, and advance examination. Thus, the next strategy to help victims of human trafficking can be carried out.

Aim: To identify the characteristics of physical, mental, and sexual health conditions in patients victims of TPPO as well as medical measures taken.

Method: This is a systematic literature review of the literature obtained from four databases: PubMed, Google Scholar, Sage Journal, and Semantic Scholar. A literature search using the SPIDER method is initial screening and screening before downloading. Selected literatures then put for further selection with criteria of inclusion and exclusion to obtain eligible literature. The next step is ecstraction by conducting a critical review using a checklist according to the design of literature research.

Result: Five literatures are eligibile with 2 literature conduct medical examinations, 4 literature discussing physical health issues, 3 literature discussing reproductive health issues, and 4 literature discussing mental health issues. Some of the literatures show the most common physical health problems are tired, memory impairment, and headaches or dizziness. Sexual health problems are sexually transmitted infections, urination pain in women and the risk of pregnancy. Mental health problems are PTSD, anxiety, and depression, desire and even suicide attempts, substance or alcohol use.

Conclusion: Victims of human trafficking (men, women, and children) experience physical, sexual, and mental health problems.