bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficient algorithmic coupling technique for precision recycling of seven types of mixed plastic waste
Authors: Zhu Keyu , Pan Zhijie , Chen Junrong , Yang Songwei , Cao Changlin , Li Jianjun , Liu Siyang , Wang Hai , Qian Qingrong , Chen Qinghua 
Published: March 2024

Abstract
The annual global production of plastic waste, characterized by complex composition and challenges in separation, necessitates immediate and comprehensive measures for the recycling and disposal of mixed plastic waste in an environmentally friendly and meticulous manner. This study introduces an efficient two-step coupling technique, employing Linear Support Vector Classification (Linear-SVC) in tandem with Multi-layer Perceptron (MLP). The application of this coupling technique elevates the overall accuracy of identifying seven types of plastics from 94.7% to an impressive 97.7%. Furthermore, the method exhibits a reduced running time compared to the one-step method of MLP. Notably, the classification accuracy for high-density polyethylene (HDPE) and low-density polyethylene (LDPE) experiences a substantial improvement from 79–94%, outperforming the one-step MLP method. This coupling technique emerges as an effective strategy, contributing significantly to the harmless and precise recycling of waste plastics.
Experimental and numerical evaluation of the seismic behavior of steel plate shear walls with and without openings
Authors: Rashti Abbas Akbarpour Nikghalb , Eftekhari Mohammad Memar , Rudsari Mehrzad Tahamoli 
Published: March 2024

Abstract

Steel plate shear walls are one of the modern seismic engineering systems used as a lateral load-bearing system. In this study, two shear walls specimens with and without an opening, incorporating stiffeners in their upper beams, were subjected to cyclic loading in an experimental setting. The walls had a scale of one-third and were tested under cyclic displacement control loading. Subsequently, due to the limitations of specimen fabrication and laboratory testing, the ABAQUS software was used for numerical modeling and analysis, with a total of 6 models being numerically analyzed. Prior to the numerical analysis and in order to verify the results, a numerical validation was performed using a specimen with an opening of 25% and its corresponding numerical model. The opening in the specimens was considered as the independent variable, and the ductility, maximum base shear, and stiffness of the models were considered as dependent variables. For this purpose, the hysteretic curve of each specimen was extracted, which was then used to derive the equivalent bilinear and backbone curves. Finally, based on these curves, the models’ seismic parameters, including the base shear, ductility, and stiffness were calculated. Furthermore, this study demonstrates that with an increase in the percentage of the opening, the parameters of base shear, ductility, and stiffness experience a change, with the smallest change observed in the stiffness of the models. Finally, a set of equations were proposed for structural designers and engineers to calculate the seismic parameters based on the percentage of openings.
Impact of immediate post SARS-CoV-2 lockdown on suicide in northern Tunisia
Authors: Mrad Seifeddine , Bram Nesrine , Harzallah Hana , Bchir Khaled , Charfi Fatma , Labbane Raja , Hamdoun Moncef , BenKhelil Mehdi 
Published: March 2024

Abstract

Suicide is a multifactorial phenomenon influenced by pre-existing mental disorders and by the occurrence of detrimental societal changes. The stress related to the SARS-CoV-2 pandemic as well as the health prevention measures had a negative psychological impact on certain vulnerable populations. Our aim was to investigate suicidal trends and to compare suicide decedent’s profile before and after the lockdown. A descriptive and analytical cross-sectional study was conducted including all suicides that occurred in the north of Tunisia during the study period. Suicidal trends, were studied using an interrupted time series analysis while suicide decedent’s profile was compared between the study period from 24/05/2020 to 31/08/2020 and this same period of the previous five years. Interrupted Time Series Analysis showed a sporadic variation without significant peaks while the comparative study showed a significant increase, among suicide decedents after the lockdown, of individuals with a history of psychiatric disorders particularly mood disorders, suicidal attempts, alcohol and cannabis use and professional instability. We also observed an increase in suicides by hanging and precipitation against a decrease in immolations and intoxications. Our study highlights the importance of mental health promotion during health crises and of prevention especially among vulnerable people.
A European pharmacogenomic study of the response to opioids in advanced cancer patients identifies germline variants associated with nausea-vomiting side effect
Authors: Minnai Francesca , Shkodra Morena , Noci Sara , Brunelli Cinzia , Pigni Alessandra , Zecca Ernesto , Skorpen Frank , Klepstad Pal , Kaasa Stein , Corli Oscar , Pallotti Maria Caterina , Maltoni Marco Cesare , Caraceni Augusto Tommaso , Colombo Francesca 
Published: March 2024

Abstract

Opioids are the mainstay therapy for patients affected by moderate to severe cancer pain, yet in about 10–20% of the cases, patients do not benefit from the received analgesic treatment or experience side effects. Genetic variability might account for the variation in individual responses to opioids, both in terms of efficacy and toxicity. The aim of this genome-wide association study (GWAS) was to identify new genetic markers of opioid toxicity in terms of nausea-vomiting. Cancer patients receiving morphine, oxycodone, buprenorphine, and fentanyl were recruited from different European cancer centers. Data about toxicity (nausea-vomiting score, NVS) and other relevant clinical information were collected. DNA samples were genotyped using Axiom Precision Medicine Research Arrays. Linear regression between genotypes of 2,059 patients and NVS was performed, using the REGENIE pipeline. Sex, age, study, and country were included in the model as covariates. We found 68 variants associated with NVS (P-value < 1.0 x 10− 6). Of note, 15 intronic variants on chromosome 2 were located in the NPAS2 gene, encoding a circadian transcription factor reported to play a role in another opioid side effect, the alteration of sleep. Some of these variants were previously identified as splicing quantitative trait loci of the NPAS2 gene. This is the first GWAS, performed in more than two thousand individually genotyped patients treated with opioids for cancer pain, that investigated the genetic bases of opioid-induced nausea-vomiting. Although further studies are needed to confirm our findings and to characterize the functional role of the identified variants, our results emphasize the importance of performing large pharmacogenomic studies to identify germline variants associated with opioid response, with the ultimate goals of improving personalization of cancer pain therapies.
Lateral gene transfer leaves lasting traces in Rhizaria
Authors: Eme Laura , Hooff Jolien van 
Published: March 2024

Abstract

Lateral gene transfer (LGT) is a fundamental process that has contributed to the genetic makeup of various eukaryotic lineages. Yet our comprehension of its prevalence and significance across the eukaryotic domain remains incomplete, particularly when it comes to eukaryote-to-eukaryote transfers. The Rhizaria forms an expansive, ancient, and morphologically diverse clade of mostly free-living, single-celled phagotrophs, whose genetic diversity reflects their adaptability and evolutionary success across a range of habitats. Here, we undertake a comprehensive investigation of LGT within Rhizaria, tracing its role from the clade's emergence to the present day, employing advanced phylogenetic analyses and machine learning techniques. Contrary to previous assertions that LGT in eukaryotes is rare, our findings suggest that at least 8% of genes in contemporary rhizarian genomes were acquired through LGT at various points during their billion-year history. Our analysis reveals that although gene duplications exceed the number of LGT events, the duplicated genes that were originally acquired through LGT have a visible effect on the evolutionary trajectory of the recipient organisms. Our results also indicate that LGTs originating from other eukaryotes are more common than those from prokaryotes and exhibit unique patterns. By offering both quantitative and qualitative insights into the role of LGT in shaping the evolution of a major eukaryotic lineage, this work further demystifies lateral gene transfer in eukaryotes.
The Animal Signs in Determining Good and Bad Days in the Ala Ayuning Dewasa on Balinese Caka Calendar
Authors: Swandana I Wayan , Paramarta I K. 
Published: March 2024

Time determines the good and bad day to start doing something in Balinese society. This study aims to analyze the sign system in the Ala Ayuning Dewasa on the Balinese Caka Calendar. Data is taken from the Balinese Caka Calendar 2023. There are two types of data in this study, namely written and oral data. Written data is in the form of animal name terms and their meanings. Oral data is a description of the relationship between signifiers and signifieds. Written data were collected through observation assisted by note-taking techniques. Researchers observed the sign system in the Ala Ayuning Dewasa on the Balinese Caka Calendar and noted it in the sheets provided. Oral data were obtained from three informants who wrestled with the Ala Ayuning Dewasa on the Balinese Caka Calendar through interviews. The results showed that (1) signifiers were formed from a combination of times called wewaran, wuku, and penanggal/pangelong, (2) there were 20 animal terms consisting of 9 forms of noun phrases, and 11 simple clauses, (3) signifiers and signifieds have a connotation relationship, (4) signifieds are complex which means that one signified can have the meaning of good das, bad day, good and bad days, even one signifier can have up to 5 meanings. This research is a sound guide for Hindus in Bali to discover the meaning of the relationship between animal signifiers and their signifieds in the Ala Ayuning Dewasa on the Balinese Caka Calendar.
A Corpus-Based Analysis of Word â€˜Ghostâ€™ in the Collection of Kenyah Stories
Authors: Syarifah Laily , Febiyani Febiyani , Anjani Novira , Munawarah Siti , Putri Jairatunnisyah Jaidun , Asih Yuni Utami , Kalukar Ventje Jany 
Published: March 2024

To illustrate the concept of ghosts, this research aimed to explain how they were described in Ã’ma LÃ³ngh and Lebuâ€™ Kulit language, the collection of Dayak Kenyah short stories. This research employed a descriptive qualitative method based on figurative language personification theory. Data analysis is conducted using corpus analysis with the AntConc application. This research concluded that there are four categories that employ personification in relation to the term 'ghost' namely the ghosts act like human, the ghosts being described as dying like humans, ghosts can transform into other forms and ghosts being described as animals. The use of personification in these stories allows readers to relate to and believe in the ghost, enhancing the drama and suspense of the story. The ghosts in this research were only described using personification. Further research might investigate ghosts through different theories to see how their appearance can contribute to certain meanings in the stories.
Realization of Appraisal and Ideology in Ferdy Sambo Case in Editorial Text of "Kasus Sambo Isih Dawa" and "Ganjaran Murwat Tumrap Kejujuran" in Panjebar Semangat Magazine
Authors: Risdianto Faizal , Nugroho Haryo Aji , Sunardi Sunardi , Arkida Teisar 
Published: March 2024

This research aims to identify appraisal devices in two editorial texts in the Javanese magazine Panjebar Semangat on the news texts of Ferdy Sambo case entitled Kasus Sambo Isih Dawa and Ganjaran Murwat Tumrap Kejujuran and describe the ideology of the author of the editorial text. Data were analyzed using the Appraisal System in Functional Systemic Linguistics, including Attitude, Graduation, and Engagement. The results of the appraisal analysis on the first text are 69 attitudes data from 68 clauses. A total of 69 attitudes data were found, consisting of 33 positive attitudes and 36 negative attitudes. Monogloss data with 44 data dominate these attitudes compared to heterogloss data with 25 data. In terms of Graduation, journalists used the intensifier type only eight times. For the second text, 55 attitudes data from 48 clauses. The total of 55 data was dominated by positive evaluations of 43 data, while there were only 12 negative evaluations. It can be interpreted that this editorial text has a very positive nuance. The text is dominated by monogloss data, namely 47 data, compared to heterogloss data, which is only 8 data. The outcomes of the analysis conducted on the editorial texts within the Panjebar Semangat Javanese magazine indicate a predominant reliance on judgment as the principal method of Appraisal, succeeded by appreciation and affect. The analysis explicitly emphasizes the assessment of individual character traits, with Richard, Sambo, and Putri identified as the primary subjects of evaluation. This finding underscores the potential of news as a mechanism for the exercise of social control, with the deployment of judgment serving to consolidate specific societal values and beliefs. This editorial text makes journalists themselves the dominant source of evaluators. In terms of Graduation, journalists also tend to increase their Attitude appraisal using intensifiers. The dominance of monogloss in the editorial text is linguistic evidence that the journalist deliberately composed the editorial text using the point of view of himself.
Anti-NMDA Receptor Encephalitis, Human Papillomavirus, and microRNA
Authors: Wang Hsiuying 
Published: March 2024

Background:
Anti-N-methyl-d-aspartate (Anti-NMDA) receptor encephalitis
is a rare autoimmune disease, which is caused by antibodies attacking NMDA receptors
in the brain. Previous studies revealed that this disorder might be induced by vaccination.
Vaccination is the most useful strategy to prevent human or animal infectious diseases.
Although vaccines can produce immunity against diseases, at low risk, they may
trigger serious adverse events. Anti-NMDA receptor encephalitis has been studied to be
related to the H1N1 (influenza A virus subtype H1N1), tetanus/diphtheria/pertussis and
polio vaccine, Japanese encephalitis, yellow fever, and coronavirus disease 2019
(COVID-19) vaccination. Several cases have been reported that anti-NMDA receptor encephalitis
could also be triggered by the human papillomavirus (HPV) vaccine. However,
there is a lack of studies to investigate the underlying mechanism.

Methods:
In this paper, the association between anti-NMDA receptor encephalitis and
HPV vaccination is discussed in terms of their microRNA (miRNA) biomarkers. Phylogenetic
tree and distance similarity analyses are used to explore the relationship between
their miRNA biomarkers.

Results:
The results show a higher degree of similarity between miRNA biomarkers associated
with HPV and anti-NMDA receptor encephalitis or related vaccines when compared
to the overall miRNAs. It indicates that while the risk of HPV triggering anti-NMDA
receptor encephalitis is low, a connection between anti-NMDA receptor encephalitis
and HPV vaccination cannot be ruled out.

Conclusion:
This finding suggests that in cases where individuals receiving HPV vaccination
experience psychiatric or neurological symptoms, it should be considered to diagnose
anti-NMDA receptor encephalitis, given the exclusion of other possible complications.
The Protective Effects of Curcumin against Renal Toxicity
Authors: Zhai Jianan , Chen Zhengguo , Zhu Qi , Guo Zhifang , Wang Ningning , Zhang Cong , Deng Haoyuan , Wang Shaopeng , Yang Guang 
Published: March 2024

:
Curcumin is a naturally polyphenolic compound used for hepatoprotective,
thrombosuppressive, neuroprotective, cardioprotective, antineoplastic, antiproliferative,
hypoglycemic, and antiarthritic effects. Kidney disease is a major public health problem
associated with severe clinical complications worldwide. The protective effects of curcumin
against nephrotoxicity have been evaluated in several experimental models. In this
review, we discussed how curcumin exerts its protective effect against renal toxicity and
also illustrated the mechanisms of action such as anti-inflammatory, antioxidant, regulating
cell death, and anti-fibrotic. This provides new perspectives and directions for the
clinical guidance and molecular mechanisms for the treatment of renal diseases by curcumin.
Multi-omics Data Integration Analysis Identified Therapeutic Targets and Potential Reuse Drugs for Osteoporosis
Authors: Li Mingdong , Gao Xing , Zhang Yuchen , Wang Jinglei , Dong Run , Li Peng , He Yongxiong 
Published: March 2024

Aims:
To facilitate drug discovery and development for the treatment of osteoporosis

Background:
With global aging, osteoporosis has become a common problem threatening the
health of the elderly. It is of important clinical value to explore new targets for drug intervention
and develop promising drugs for the treatment of osteoporosis.

Objective:
To understand the major molecules that mediate the communication between the cell
populations of bone marrow-derived mesenchymal stem cells (BM-MSCs) in osteoporosis and osteoarthritis
patients and identify potential reusable drugs for the treatment of osteoporosis.

Methods:
Single-cell RNA sequencing (scRNA-seq) data of BM-MSCs in GSE147287 dataset
were classified using the Seurat package. CellChat was devoted to analyzing the ligand-receptor
pairs (LR pairs) contributing to the communication between BM-MSCs subsets. The LR pairs that
were differentially expressed between osteoporosis samples and control samples and significantly
correlated with immune score were screened in the GSE35959 dataset, and the differentially expressed
gene in both GSE35959 and GSE13850 data sets were identified as targets from a single ligand
or receptor. The therapeutic drugs for osteoporosis were screened by network proximity
method, and the top-ranked drugs were selected for molecular docking and molecular dynamics simulation
with the target targets.

Results:
Twelve subsets of BM-MSCs were identified, of which CD45-BM-MSCS_4, CD45-BM-
MSCS_5, and CD45+ BM-MSCs_5 subsets showed significantly different distributions between
osteoporosis samples and osteoarthritis samples. Six LR pairs were identified in the bidirectional
communication between these three BM-MSCs subsets and other BM-MSCs subsets.
Among them, MIF-CD74 and ITGB2-ICAM2 were significantly correlated with the immune
score. CD74 was identified as the target, and a total of 48 drugs targeting CD47 protein were identified.
Among them, DB01940 had the lowest free energy binding score with CD74 protein and
the binding state was very stable.

Conclusion:
This study provided a new network-based framework for drug reuse and identified
initial insights into therapeutic agents targeting CD74 in osteoporosis, which may be meaningful
for promoting the development of osteoporosis treatment.
Cellular and Mitochondrial Pathways Contribute to SGLT2
Inhibitors-mediated Tissue Protection: Experimental and Clinical Data
Authors: Sanz Raúl Lelio , Menéndez Sebastián García , Inserra Felipe , Ferder León , Manucha Walter 
Published: March 2024

Abstract:
In metabolic syndrome and diabetes, compromised mitochondrial function emerges as a critical driver of cardiovascular disease, fueling its development and persistence, culminating in cardiac remodeling and
adverse events. In this context, angiotensin II - the main interlocutor of the renin-angiotensin-aldosterone system - promotes local and systemic oxidative inflammatory processes. To highlight, the low activity/expression
of proteins called sirtuins negatively participates in these processes, allowing more significant oxidative imbalance, which impacts cellular and tissue responses, causing tissue damage, inflammation, and cardiac and vascular remodeling. The reduction in energy production of mitochondria has been widely described as a significant
element in all types of metabolic disorders. Additionally, high sirtuin levels and AMPK signaling stimulate hypoxia-inducible factor 1 beta and promote ketonemia. Consequently, enhanced autophagy and mitophagy advance through cardiac cells, sweeping away debris and silencing the orchestra of oxidative stress and inflammation, ultimately protecting vulnerable tissue from damage. To highlight and of particular interest, SGLT2 inhibitors (SGLT2i) profoundly influence all these mechanisms. Randomized clinical trials have evidenced a
compelling picture of SGLT2i emerging as game-changers, wielding their power to demonstrably improve cardiac function and slash the rates of cardiovascular and renal events. Furthermore, driven by recent evidence,
SGLT2i emerge as cellular supermolecules, exerting their beneficial actions to increase mitochondrial efficiency, alleviate oxidative stress, and curb severe inflammation. Its actions strengthen tissues and create a resilient
defense against disease. In conclusion, like a treasure chest brimming with untold riches, the influence of
SGLT2i on mitochondrial function holds untold potential for cardiovascular health. Unlocking these secrets,
like a map guiding adventurers to hidden riches, promises to pave the way for even more potent therapeutic
strategies.
Innovative Strategies to Enhance mRNA Vaccine Delivery and Effectiveness:
Mechanisms and Future Outlook
Authors: Verma Abhishek , Awasthi Ankit 
Published: March 2024

Abstract:
The creation of mRNA vaccines has transformed the area of vaccination and allowed for the production
of COVID-19 vaccines with previously unheard-of speed and effectiveness. The development of novel
strategies to enhance the delivery and efficiency of mRNA vaccines has been motivated by the ongoing constraints
of the present mRNA vaccine delivery systems. In this context, intriguing methods to get beyond these
restrictions include lipid nanoparticles, self-amplifying RNA, electroporation, microneedles, and cell-targeted
administration. These innovative methods could increase the effectiveness, safety, and use of mRNA vaccines,
making them more efficient, effective, and broadly available. Additionally, mRNA technology may have numerous
and far-reaching uses in the field of medicine, opening up fresh avenues for the diagnosis and treatment
of disease. This paper gives an overview of the existing drawbacks of mRNA vaccine delivery techniques,
the creative solutions created to address these drawbacks, and their prospective public health implications.
The development of mRNA vaccines for illnesses other than infectious diseases and creating scalable
and affordable manufacturing processes are some of the future directions for research in this area that are covered
in this paper.