bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chicken UFL1 Restricts Avian Influenza Virus Replication by Disrupting the Viral Polymerase Complex and Facilitating Type I IFN Production
Authors: Li Weiqiang , Lin Yu , Wang Xiyi , Yang Huixing , Ding Yangbao , Chen Zuxian , He Zhuoliang , Zhang Junsheng , Zhao Luxiang , Jiao Peirong 
Published: March 2024

Abstract
During avian influenza virus (AIV) infection, host defensive proteins promote antiviral innate immunity or antagonize viral components to limit viral replication. UFM1-specific ligase 1 (UFL1) is involved in regulating innate immunity and DNA virus replication in mammals, but the molecular mechanism by which chicken (ch)UFL1 regulates AIV replication is unclear. In this study, we first identified chUFL1 as a negative regulator of AIV replication by enhancing innate immunity and disrupting the assembly of the viral polymerase complex. Mechanistically, chUFL1 interacted with chicken stimulator of IFN genes (chSTING) and contributed to chSTING dimerization and the formation of the STING-TBK1-IRF7 complex. We further demonstrated that chUFL1 promoted K63-linked polyubiquitination of chSTING at K308 to facilitate chSTING-mediated type I IFN production independent of UFMylation. Additionally, chUFL1 expression was upregulated in response to AIV infection. Importantly, chUFL1 also interacted with the AIV PA protein to inhibit viral polymerase activity. Furthermore, chUFL1 impeded the nuclear import of the AIV PA protein and the assembly of the viral polymerase complex to suppress AIV replication. Collectively, these findings demonstrate that chUFL1 restricts AIV replication by disrupting the viral polymerase complex and facilitating type I IFN production, which provides new insights into the regulation of AIV replication in chickens.
Ankle Scientific Knowledge and Physiotherapy Practice: A Thematic Analysis of Clinical Behaviors of French-Speaking Physiotherapists
Authors: Tourillon Romain , Delahunt Eamonn , Fourchet François , Picot Brice , M’Baye Massamba 
Published: March 2024

Context
Chronic ankle instability (CAI) is prevalent among individuals who sustain a lateral ankle sprain (LAS) injury. The persistence of the characteristic long-standing clinical symptoms of CAI may be attributable to the lack of adoption by physiotherapists of evidence-informed clinical guidelines.

Objective
To investigate the extent to which French-speaking physiotherapists implement the International Ankle Consortium rehabilitation-oriented assessment (ROAST) framework when providing clinical care for individuals with an acute LAS injury.

Design
Cross-sectional study.

Setting
Online survey informed by a Delphi process of foot-ankle experts.

Patients or Other Participants
A total of 426 French-speaking physiotherapists completed the online survey.

Main Outcome Measure(s)
The survey was disseminated to French-speaking physiotherapists in France; Switzerland; Quebec, Canada; Luxembourg; and Belgium. It comprised closed and open-ended questions organized in 5 sections: (1) participant demographics, (2) participant self-assessment of expertise, (3) clinical diagnostic assessment of the ankle (bones and ligaments), (4) clinical evaluation after an acute LAS injury (ROAST framework), and (5) CAI. The qualitative data from the open-ended questions were analyzed using best-practice thematic-analysis guidelines.

Results
Only 6.3% (n = 27) of the respondents could name all Ottawa Ankle Rules criteria. Only 25.6% (n = 109) of the respondents cited or described criterion standard tests from the literature to assess the integrity of the lateral ankle ligaments. Less than 25% (n = 71) of the respondents reported using clinical evaluation outcome metrics (ROAST) recommended by the International Ankle Consortium to inform their clinical care for individuals with an acute LAS injury. In general, the respondents had a greater knowledge of the functional than the mechanical insufficiencies associated with CAI.

Conclusion
A minority of French-speaking physiotherapist survey respondents use the International Ankle Consortium ROAST to inform their clinical care for individuals with an acute LAS injury. This highlights the responsibility of the scientific community to better disseminate evidence-informed research to clinicians.
The Adolescent Patient Perspective on Activity Limitations After Sport-Related Concussion
Authors: Valovich McLeod Tamara C. , Williams Richelle M. , Snyder Valier Alison R. 
Published: March 2024

Context
Assessment of sport-related concussion (SRC) has begun to include patient-reported outcome measures. However, understanding of which health limitations are most meaningful to adolescents after SRC is limited.

Objective
To explore patient-perceived activity limitations after SRC and throughout recovery to return to play and mapped according to the International Classification of Functioning, Disability, and Health (ICF) model.

Design
Longitudinal study.

Setting
Secondary school athletic training facilities.

Patients or Other Participants
Fifty patients (41 males, 5 females, 4 sex not reported, age = 14.9 ± 3.5 years, grade = 10.2 ± 0.93 level) with a medically diagnosed SRC.

Intervention(s)
The Patient Specific-Functional Scale (PSFS) was used to assess changes in the patient’s condition and the effect the injury posed on their ability to perform activities. The PSFS is a self-reported assessment of health used to identify activity limitations and rate the difficulty of performing those tasks. The PSFS was administered to patients on days 3 (D3) and 10 (D10) after SRC and at return to play.

Main Outcome Measure(s)
Activities affected by injury were coded into common categories and themes by a 3-person research team for subsequent analysis. The coded themes were also mapped to the ICF domains, chapters, and categories. The dependent variables were the PSFS themes, number of activities endorsed, PSFS scores, ICF domains, chapters, and categories. Descriptive analyses and frequencies were reported for the dependent variables.

Results
A total of 157 different activities were identified at D3 and coded into 28 categories that fit into 6 themes: activities of daily living, cognitive and school (COG), sports and physical activity (SPA), screen time, sleep, and social. On D3, all patients (50/50) identified at least 1 activity limitation. Most related to SPA (37.6%) and COG (31.2%). Sixty percent of patients endorsed activity limitations at D10, primarily in COG (38.6%) and SPA (36.6%). All (100%) response categories were mapped to the ICF, with most (75%) fitting the activities and participation domain.

Conclusions
Our primary findings suggest that SRC influences many facets of the lives of adolescent athletes. Specifically, adolescent athletes identified activity restrictions primarily related to physical activity and sports participation.
Collegiate Adapted Athlete Baseline Performance on the Vestibular/Ocular Motor Screening
Authors: Moran Ryan N. , Curry Alexandra , Guin J. Russell , Stran Margaret 
Published: March 2024

Context
Concussion assessment in adapted and parasport athletes has continued to evolve with growing considerations in parasports, but little is known about vestibular/ocular performance assessment in this sample.

Objective
To examine baseline performance on the Vestibular/Ocular Motor Screening (VOMS) in collegiate adapted athletes. A secondary objective was to investigate the role of sex, history of concussion, and functional classification on baseline measures.

Design
Cross-sectional study.

Setting
University adapted athletics facility.

Patients or Other Participants
Fifty-four collegiate adapted athletes (age = 21.19 ± 2.6 years) from multiple institutions’ adapted athletics programs across the United States.

Main Outcome Measure(s)
Adapted athletes completed a baseline VOMS assessment while at the host university for in-season competition and tournaments. Independent variables were sex, history of concussion and functional classification (1.0–4.5 at 0.5 intervals). Vestibular/Ocular Motor Screening performance consisted of pretest symptoms (headache, dizziness, nausea, and fogginess) and postitem (eg, smooth pursuits, saccades) symptom provocation or change from pretest scores.

Results
A proportion of 50.9% reported zero symptom provocation on the VOMS, with 72% having no pretest symptoms. No sex differences were noted on the VOMS (P &gt; .05); however, adapted athletes with a history of concussion reported greater VOMS provocation on horizontal saccades (P = .008) than those with no history. Higher functional classifications (2.0–4.5) reported greater provocation on horizontal saccades (P = .010), horizontal and vertical (P = .043 and .048) vestibular/ocular reflex, and vestibular/ocular reflex cancellation (P = .036) than 1.0–1.5 athletes.

Conclusions
Our findings provide context for baseline VOMS performance in collegiate adapted athletes and identifying modifiers at baseline. Special consideration is warranted on vestibular and oculomotor assessment in adapted and parasport athletes with a history of concussion and higher functional classifications.
Oncological outcomes of post neo adjuvant chemotherapy breast conservation surgery in patients with locally advanced breast cancer
Authors: Bhargava Priyank , Suhani  , Parshad Rajinder , Bhattacharjee Hemanga K. , Haresh KP , Goyal Ankur , Manchanda Smita , Mathur Sandeep 
Published: March 2024

Abstract

Introduction:
Breast cancer in India is phenotypically different with locally advanced breast cancers (LABCs) forming 30–50% of all cases. Use of neoadjuvant chemotherapy (NACT), among other things has contributed to surgeons using breast conservation surgery (BCS) in very selected patients with good results. Herein, we describe the oncological outcomes of BCS in LABC patients undergoing surgery post NACT.

Patients and Methods:
This is an ambispective observational cohort study conducted between January 1996 and December 2019 after approval by Institute Ethics Committee, to study the ipsilateral breast tumor recurrence (IBTR) in patients with LABC undergoing BCS post NACT. The secondary objectives were to ascertain the disease-free survival (DFS) and overall survival (OS) and factors associated with IBTR in these patients. Patients were staged according to the anatomic American Joint Committee on Cancer (AJCC) VIII Tumor Node Metastasis (TNM) classification and clinic-demographic, pathologic, treatment, and follow-up details were noted.

Results:
Out of 822 patients with LABC, 71 patients undergoing BCS post NACT were included. Average tumor size at presentation was 6.43 cm. The most common T stage was T3 (57.7%) and N stage was N1 (53.5%). The most common stage group was IIIB in 40.8%. Around 75% received anthracycline-based NACT with 28.2% having a complete clinical response. A pathological complete response was seen in 16 patients (22.5%). The mean follow-up duration was 6.14 years. A total of 25 patients had recurrences: five patients had IBTR (7%) and four had a local with regional recurrence. Two, 5, and 10 years OS were 94.0, 83.8, and 61.9%, respectively, and DFS were 87.8, 67.1, and 50.6%, respectively. A higher clinical T stage was associated with poor DFS (p = 0.01). The risk of IBTR was not found to significantly correlate with any of the standard prognostic factors.

Conclusion:
BCS post NACT in suitably selected patients of LABC is a safe and viable option without adversely affecting oncological outcomes.
Vorhersagen und Kontrollieren: Verhaltenswissen und Verhaltenspolitik in der Zeitgeschichte
Authors: Graf Rüdiger 
Published: March 2024

Das Buch untersucht den Aufstieg des Verhaltenswissens seit der Mitte des 20. Jahrhunderts sowie dessen praktische und politische Konsequenzen Die Frage, wie menschliches Verhalten beeinflusst werden kann, ist in der jüngsten Zeitgeschichte virulenter geworden. Auf der Basis verhaltenswissenschaftlicher Erkenntnisse versprechen Expert:innen, Menschen durch subtile Interventionen glücklicher, gesünder und wohlhabender zu machen. Zugleich haben die Digitalisierung und Datafizierung unserer Welt Ängste vor einer umfassenden Verhaltensmanipulation und -kontrolle verschärft. Das Buch zeigt, dass es keineswegs selbstverständlich ist, Menschen nicht als handelnde Subjekte, sondern als sich verhaltende Organismen zu begreifen. Es untersucht, wie seit der Behavioral Revolution in der Mitte des 20. Jahrhunderts in verschiedenen Wissensfeldern, von den Wirtschafts- über die Psychowissenschaften bis zur Kriminologie, ein spezifisches Verhaltenswissen entwickelt wurde. Davon ausgehend analysiert es dessen Bedeutung für den Wandel politischer Steuerungstechniken vor allem in Bezug auf das Umwelt-, Gesundheits- und Finanzverhalten seit den 1970er Jahren.
Model Owens Kadakia-Learning Cluster Design untuk Meningkatkan Keterampilan Numerasi, Komunikasi, dan Berpikir Kritis Matematika Kelas I Sd XYZ Bekasi
Authors: Wulandari Priska Yovita Tri Wahyuningrum 
Published: March 2024

This study aims to analyze the difference between numeracy, critical thinking and communication skills in classes that apply OK-LCD with classes that apply the lecture method. The subjects of the study were grade I elementary school students in Bekasi totaling 28 people for the control class and 27 people for the experimental class. The study period was conducted for four weeks starting October 2 to October 20, 2023. This study used a weak experimental design method with a static-group pretest-posttest design model. Research data are obtained through written tests and rubrics that have been tested for validity and reliability. The results of the analysis and statistical tests showed the difference in control class pretest scores with control class post test, experimental class pretest scores with experimental class post test, and control class nGain with experimental class nGain on numeracy skills, critical thinking rubrics, and student communication rubrics. The data were expressed in the average nGain in the experimental class for numeracy, critical thinking and communication skills with consecutive scores of 0.56; 0,57; and 0.66. On average nGain in the control class for numeracy, critical thinking, and communication skills with consecutive scores of 0.40; 0,42; and 0.59. Therefore, it can be concluded that there is an increase in numeracy, critical thinking and communication skills in the control class and experimental class.
ANALISIS HUKUM PENERAPAN SANKSI PIDANA PENYALAHGUNAAN NARKOTIKA OLEH HAKIM DITINJAU DARI SEMA NOMOR 4 TAHUN 2010 DI KOTA PALEMBANG
Authors: Akrom Choirul Nur , Octavianus R. , Nirwan Nirwan , Putra Muhammad Arif Syah , Arista Windi 
Published: March 2024

Abstrak
Penegakan hukum terhadap penyalahgunaan narkotika telah banyak dilakukan oleh aparat penegak hukum dan telah mendapat putusan hakim disidang pengadilan. Penegakan hukum diharapkan mampu memberikan jawaban yang membuat para peyalahgunaan narkotika dapat kembali hidup sebagaimana mestinya, oleh sebab itu dalam kenyataannya putusan yang diberikan oleh hakim berupa hukuman penjara dan bukan rehabilitasi. Penerapan Sanksi Penyalahgunaan Narkotika ditinjau dari SEMA Nomor 4 tahun 2010 di Kota Palembang berjalan sebagaimana yang diharapkan oleh Sema itu sendiri hal tersebut dapat terlihat dari data yang ada di BNN 3 tahun terakhir 2020-2022 yang terindikasi pecandu sebanyak 1.433 orang yang dilanjutkan penyidikan sebanyak 100 orang. Faktor-faktor penghambat tidak dapat diterapkannya hukum secara maksimal terhadap Undang-Undang Nomor 35 tahun 2009 tentang Narkotika di Kota Palembang, yang pertama kurang peran serta masyarakat, kedua masyarakat kurang memahami tugas dari BNN, ketiga bagi pengguna narkoba masih dianggap tabu oleh masyarat, kerena masyarakat merasa malu keluarganya tersangkut paut dengan narkoba, disamping hal-hal tersebutlah BNN terkendala untuk menangkap pengguna narkoba, kurangnya tempat rehabilitas, untuk keluarga ada yang takut anaknya ditangkap, padahal sebenarnya kalau ditangkap bukan berarti dipenjara, tetapi ada kemungkinan bisa direhabilitas dan rawat jalan, ini membuat BNN terkendala dalam menindak pengguna narkoba karena dari pihak keluarga tidak mau kerja sama dengan pihak BNN dan adanya membatasi ruang gerak Penegak Hukum diantaranya Sema Nomor 4 tahun 2010 tentang Penempatan Korban Penyalahgunaan Dan Pecandu Narkotika Kedalam Lembaga Rehabilitasi Dan Rehabilitasi Sosial.
Kata Kunci : Sema Nomor 4 tahun 2010, Korban, BNN
ANALISIS HUKUM PENGAWASAN PELAKSANAAN TENDER PROYEK PEMERINTAH DAERAH DENGAN PIHAK SWASTA DALAM PERSPEKTIF HUKUM PERSAINGAN USAHA DI KOTA PALEMBANG
Authors: Abidin Zainal , Supardiansah Supardiansah , Syamsuddin Syamsuddin , Utoyo Marsudi 
Published: March 2024

Abstrak
Memiliki banyak hasil alam merupakan suatu penyebab banyaknya pedagang yang datang ke Palembang untuk membeli barang dagangan yang berupa rempah-rempah, getah kayu pewarna, lilin, gading gajah, dan timah. Pedagang-pedagang ini umumnya datang dari Jawa, Cina, Arab, India, Malaka dan Eropa. Para pedagang singgah di Palembang dalam jangka waktu yang lama karena menunggu pasang surut air laut serta perubahan arah angin. Pada masa ini, mereka membuat perkampungan-perkampungan tersendiri. Pelaksanaan fungsi pengawasan DPRD Kota Palembang terhadap Pembangunan dalam mewujudkan Pembangunan yang diinginkan di Kota Palembang, pengawasan tentang pembangunan di Kota Palembang, secara umum dapat dikatakan bahwa pengawasan oleh DPRD dilaksanakan secara baik dan profesioanl sesuai dengan ketentuan yang ada dengan pertimbangan beberapa aspek diantaranya: a) Pengawasan terhadap peraturan perundang-undangan tentang tender; b) Pengawasan terhadap pengadministrasian; c) Pengawasan terhadap pelaksanaan pembangunan yang dilakukan oleh mitra Pemerintah Daerah Kota Palembang; dan d) Pengawasan pembentukan panitia tender yang bersih dari KKN. Melihat permasalahan tersebut selalu timbul, maka diharapkan kepada Anggota DPRD Kota Palembang, yang menjalankan salah fungsinya dalam pengawasan terhadap pembangunan di Kota Palembang, secara serius dan professional, agar pencapaian pembanguna dapat dilakukan secara maksimal.
Kata Kunci: Analisis, Tender Proyek, Swasta
All Things Medieval
Authors: Johnston Ruth A. 
Published: March 2024

All Things Medieval: An Encyclopedia of the Medieval World covers the widest definition of “medieval Europe” possible, not by covering history in the traditional, textbook manner of listing wars, leaders, and significant historic events, but by presenting detailed alphabetical entries that describe the artifacts of medieval Europe. By examining the hidden material culture and by presenting information about topics that few books cover—pottery, locks and keys, shoes, weaving looms, barrels, toys, pets, ink, kitchen utensils, and much more—readers get invaluable insights into the nature of life during that time period and area.
A generic algorithm to automatically classify urban fabric according to the local climate zone system: implementation in GeoClimate 0.0.1 and application to French cities
Authors: Bernard Jérémy , Bocher Erwan , Gousseff Matthieu , Leconte François , Le Saux Wiederhold Elisabeth 
Published: March 2024

Abstract. Geographical features may have a considerable effect on local climate. The local climate zone (LCZ) system proposed by Stewart and Oke (2012) is nowadays seen as a standard approach for classifying any zone according to a set of urban canopy parameters. While many methods already exist to map the LCZ, only few tools are openly and freely available. This paper presents the algorithm implemented in the GeoClimate software to identify the LCZ of any place in the world based on vector data. Six types of information are needed as input: the building footprint, road and rail networks, water, vegetation, and impervious surfaces. First, the territory is partitioned into reference spatial units (RSUs) using the road and rail network, as well as the boundaries of large vegetation and water patches. Then 14 urban canopy parameters are calculated for each RSU. Their values are used to classify each unit to a given LCZ type according to a set of rules. GeoClimate can automatically prepare the inputs and calculate the LCZ for two datasets, namely OpenStreetMap (OSM, available worldwide) and the BD TOPO® v2.2 (BDT, a French dataset produced by the national mapping agency). The LCZ are calculated for 22 French communes using these two datasets in order to evaluate the effect of the dataset on the results. About 55 % of all areas have obtained the same LCZ type, with large differences when differentiating this result by city (from 30 % to 82 %). The agreement is good for large patches of forest and water, as well as for compact mid-rise and open low-rise LCZ types. It is lower for open mid-rise and open high-rise, mainly due to the height underestimation of OSM buildings located in open areas. Through its simplicity of use, GeoClimate has great potential for new collaboration in the LCZ field. The software (and its source code) used to produce the LCZ data is freely available at https://doi.org/10.5281/zenodo.6372337 (Bocher et al., 2022); the scripts and data used for the purpose of this article can be freely accessed at https://doi.org/10.5281/zenodo.7687911 (Bernard et al., 2023) and are based on the R package available at https://doi.org/10.5281/zenodo.7646866 (Gousseff, 2023).
The Relationship Between Job Satisfaction and Job Performance: A Study on Frontline Healthcare Workers
Authors: Faryal  , Irum Naqvi  
Published: March 2024

The purpose of the current study was to see the relationship between job satisfaction and job performance in frontline healthcare workers. The cross-sectional study was carried out from January to April 2022 in Pakistan, after permission was obtained from different hospitals in Peshawar, Charsadda, Rawalpindi/Islamabad, and Multan. A purposive sample of frontline healthcare workers (N= 400) having an age range of 22 to 47 years. Data was collected through a booklet comprised of demographic sheets, a job satisfaction scale, and a job performance scale (Self-rating and Supervisor-rating). Data were analyzed using SPSS-23. Results revealed that job satisfaction has a positive relationship with job performance. It has been found that female frontline healthcare workers exhibited higher extrinsic job satisfaction than male frontline healthcare workers. Moreover, paramedical staff exhibited higher job performance and job satisfaction than nurses and doctors. The results would reflect both theoretical and practical implications for hospital administrations in enhancing job performance and the development of programs to increase job satisfaction.