bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experience with a hybrid recruitment approach of patient-facing web portal screening and subsequent phone and medical record review for a neurosurgical intervention trial for chronic ischemic stroke disability (PISCES III)
Authors: Kolls Brad J. , Muir Keith W. , Savitz Sean I. , Wechsler Lawrence R. , Pilitsis Julie G. , Rahimi Scott , Beckman Richard L. , Holmes Vincent , Chen Peng R. , Albers David S. , Laskowitz Daniel T. 
Published: February 2024

Abstract
Background
Recruitment of participants is the greatest risk to completion of most clinical trials, with 20–40% of trials failing to reach the targeted enrollment. This is particularly true of trials of central nervous system (CNS) therapies such as intervention for chronic stroke. The PISCES III trial was an invasive trial of stereotactically guided intracerebral injection of CTX0E03, a fetal derived neural stem cell line, in patients with chronic disability due to ischemic stroke. We report on the experience using a novel hybrid recruitment approach of a patient-facing portal to self-identify and perform an initial screen for general trial eligibility (tier 1), followed by phone screening and medical records review (tier 2) prior to a final in-person visit to confirm eligibility and consent.

Methods
Two tiers of screening were established: an initial screen of general eligibility using a patient-facing web portal (tier 1), followed by a more detailed screen that included phone survey and medical record review (tier 2). If potential participants passed the tier 2 screen, they were referred directly to visit 1 at a study site, where final in-person screening and consent were performed. Rates of screening were tracked during the period of trial recruitment and sources of referrals were noted.

Results
The approach to screening and recruitment resulted in 6125 tier 1 screens, leading to 1121 referrals to tier 2. The tier 2 screening resulted in 224 medical record requests and identification of 86 qualifying participants for referral to sites. The study attained a viable recruitment rate of 6 enrolled per month prior to being disrupted by COVID 19.

Conclusions
A tiered approach to eligibility screening using a hybrid of web-based portals to self-identify and screen for general eligibility followed by a more detailed phone and medical record review allowed the study to use fewer sites and reduce cost. Despite the difficult and narrow population of patients suffering moderate chronic disability from stroke, this strategy produced a viable recruitment rate for this invasive study of intracranially injected neural stem cells.

Trial registration
ClinicalTrials.gov Identifier: NCT03629275
Neonatal pyocele originating from a urinary tract infection: a case report
Authors: Jamali Zahra , Shafie’ei Mohammad , Soltani Nejad Najmeh 
Published: February 2024

Abstract
Background
The origins of pyocele are primarily idiopathic, with reports suggesting the spread from intraperitoneal or hematogenous infection. However, we found no information in the literature regarding the pathogen’s spread from the urinary tract.

Case presentation
We report here a case of a 23-day-old term Iranian boy (Fars ethnicity) with complaints of new-onset fever, irritability, poor feeding, right hemiscrotal erythema, and edema. Moreover, the physical examination revealed an enlarged, erythematous, tender right hemiscrotum and edematous scrotal walls. Along with leukocytosis and elevated C-reactive protein levels, the urine culture indicated an infection with Escherichia coli. However, as the color Doppler ultrasonographic examination was inconclusive, he underwent surgical exploration on which a hydrocele sac with reddish cloudy pus fluid was noted, with its culture indicating growth with the same mentioned pathogen. Therefore, an appropriate antibiotic regimen was administered, and the patient was discharged a few days later after achieving full recovery and demonstrating no urinary tract structural abnormalities.

Conclusion
In neonatal pyocele, the spectrum of evaluating the source of the infection should also be extended to the urinary tract. Moreover, administering suitable antibiotics would produce favorable results in cases with no structural abnormalities.
Sevoflurane preconditioning in living liver donation is associated with better initial graft function after pediatric transplantation: a retrospective study
Authors: Dieu Audrey , Benoit Loïc , Dupont Candice , de Magnée Catherine , Reding Raymond , Pirotte Thierry , Steyaert Arnaud 
Published: February 2024

Abstract
Introduction
Initial allograft function determines the patient’s immediate prognosis in pediatric liver transplantation. Ischemia-reperfusion injuries play a role in initial poor graft function (IPGF). In animal studies, preconditioning with inhaled anesthetic agents has demonstrated a protective effect on the liver. In humans, the few available studies are conflicting. This study assesses the association between the hypnotic agent used to maintain anesthesia during hepatectomy in living donors and the occurrence of IPGF after pediatric transplantation.

Methods
We conducted a single-center retrospective analysis of children who received a living donor liver transplant (LDLT) between 2010 and 2019. We analyzed the incidence of EAD according to the hypnotic agent used to maintain general anesthesia during donor hepatectomy.

Results
We included 183 pairs of patients (living donors-recipients). The anesthetics used in the donor were propofol (n = 85), sevoflurane (n = 69), or propofol with sevoflurane started 30 min before clamping (n = 29). Forty-two children (23%) developed IPGF. After multivariate logistic regression analysis, factors significantly associated with the occurrence of IPGF were the anesthesia maintenance agent used in the donor (p = 0.004), age of the donor (p = 0.03), duration of transplant surgery (p = 0.009), preoperative receiver neutrophil to lymphocyte ratio (p = 0.02), and albumin (p = 0.05).

Conclusion
Significantly fewer children who received a graft from a donor in whom only sevoflurane was used to maintain anesthesia developed IPGF. Although additional research is needed, this preconditioning strategy may provide an option to prevent IPGF after living liver donation.
The combined application of hand hygiene and non-sterile gloves by nurses in a tertiary hospital: a multi methods study
Authors: Dekker Mireille , van Mansfeld Rosa , Borgert Marjon , Maaskant Jolanda , Paulus Frederique , Seller Annamarike , Jongerden Irene P. 
Published: February 2024

Abstract
Background
The application of hand hygiene (HH) and the use of non-sterile gloves (NSG) in daily care is highly intertwined. We aimed (1) to assess the combined application of HH and NSG among nurses and (2) to explore determinants that influence their ability to combine both measures in their care.

Methods
In a multi-methods study, we combined direct observations of care episodes with semi-structured interviews with nurses in two affiliated university hospitals. Topics were based on Flottorp’s checklist of determinants of practice.

Results
In total, we observed 205 care episodes and interviewed 10 nurses. Observations revealed that the combination of NSG and HH was correctly applied in 19% of care episodes in which a single procedure was executed, and in 2% of care episodes in which multiple procedures were performed. From the interviews, we found determinants that influenced compliance, covered mainly by three out of seven of Flottorp’s checklist domains. Nurses indicated that their knowledge of protocols was limited to HH and protocols were hardly ever actively consulted; visual reminders within their workplace were used as sources of information. Nurses’ behavior was primarily influenced by their ability to operationalize this information and their ability to integrate both infection prevention measures into their care. The intention to apply and combine HH and NSG use was influenced by their risk assessment of cross-contamination, by the urge to self-protect and gut feeling. The feasibility to execute HH and NSG protocols is influenced by the urgency and the complexity of the care episode.

Conclusions
The combined correct application with HH and NSG measures by nurses is low. Nurses are instructed in a fragmented way while in the day to day care HH and NSG use are highly intertwined. Operationalization and simplification of infection prevention protocols, in which instructions on both infection prevention measures are fused, should be considered. Strategies to improve practice should consider the power of habit and nurses urge to self-protect.
Systematic scoping review of automated systems for the surveillance of healthcare-associated bloodstream infections related to intravascular catheters
Authors: Lotfinejad Nasim , Januel Jean-Marie , Tschudin-Sutter Sarah , Schreiber Peter W , Grandbastien Bruno , Damonti Lauro , Lo Priore Elia , Scherrer Alexandra , Harbarth Stephan , Catho Gaud , Buetti Niccolò ,   Swissnoso Group
Published: February 2024

Abstract
Introduction
Intravascular catheters are crucial devices in medical practice that increase the risk of healthcare-associated infections (HAIs), and related health-economic adverse outcomes. This scoping review aims to provide a comprehensive overview of published automated algorithms for surveillance of catheter-related bloodstream infections (CRBSI) and central line-associated bloodstream infections (CLABSI).

Methods
We performed a scoping review based on a systematic search of the literature in PubMed and EMBASE from 1 January 2000 to 31 December 2021. Studies were included if they evaluated predictive performance of automated surveillance algorithms for CLABSI/CRBSI detection and used manually collected surveillance data as reference. We assessed the design of the automated systems, including the definitions used to develop algorithms (CLABSI versus CRBSI), the datasets and denominators used, and the algorithms evaluated in each of the studies.

Results
We screened 586 studies based on title and abstract, and 99 were assessed based on full text. Nine studies were included in the scoping review. Most studies were monocentric (n = 5), and they identified CLABSI (n = 7) as an outcome. The majority of the studies used administrative and microbiological data (n = 9) and five studies included the presence of a vascular central line in their automated system. Six studies explained the denominator they selected, five of which chose central line-days. The most common rules and steps used in the algorithms were categorized as hospital-acquired rules, infection rules (infection versus contamination), deduplication, episode grouping, secondary BSI rules (secondary versus primary BSI), and catheter-associated rules.

Conclusion
The automated surveillance systems that we identified were heterogeneous in terms of definitions, datasets and denominators used, with a combination of rules in each algorithm. Further guidelines and studies are needed to develop and implement algorithms to detect CLABSI/CRBSI, with standardized definitions, appropriate data sources and suitable denominators.
Effect of global postural reeducation on chronic low pain patients with lower cross syndrome
Authors: Kandil Enas Ahmed , Yamany Abeer Abd El Rhaman , Alsaka Samir Saad Daghash , Abd El-Azeim Alshaymaa Shabaan 
Published: February 2024

Abstract
Background
Today, low back pain is a serious global health issue. Currently, 85% of low back pain is caused by muscular imbalance and is a result of Lower cross syndrome (LCS), which are chronic postural defects. The physical therapy technique
known as Global Postural Re-education (GPR) was created in France and is based on the concept that muscle chains make up the entire muscular system.

Aim
The purpose of this study was to investigate the effect of global postural re-education on low back pain patients with lower cross syndrome.

Design
Prospective pre and post-test, single-blind randomized controlled trial.

Setting
Outpatient physio therapy clinic at Damanhur teaching hospital.

Population
Fifty participants (25 to 40 years old) suffer from low back pain with lower cross syndrome.

Methods
Participants were randomly assigned to two equal groups: global posture re-education approach and conventional physiotherapy was given to study group "A" and conventional physiotherapy was given to control group "B" throughout the course
of 15 treatment sessions, twice sessions weekly. The patients' pre- and post-treatment progress was assessed using the clinometer digital smartphone application to measure anterior pelvic tilting, flexible ruler to measure lumbar lordosis, Modified Thomas test to measure hip flexor flexibility, Visual analogue scale (VAS) to measure pain and Oswestry Low Back Pain Disability Questionnaire Arabic version to measure function disability.

Results
Comparing the study group and the control group after treatment showed that the study group had a significantly lower anterior pelvic tilting (P = 0.001), lower lumbar lordosis (p = 0,024), higher flexibility of hip flexor muscle (p = 0,001), lower VAS (p = 0,001) and improving in function disability (p = 0,001) compared to the control group.

Conclusion
Adding a Global postural re-education approach is thought to be effective in treating low back pain patients with lower cross syndrome.

Clinical Rehabilitation Impact
Global postural re-education approach decreases anterior pelvic tilting angle, lumbar lordotic angle, pain, and disability caused by low back pain and increase hip flexor flexibility.
Therapy for Stage IV Non–Small Cell Lung Cancer With Driver Alterations: ASCO Living Guideline, Version 2023.3
Authors: Jaiyesimi Ishmael A. , Leighl Natasha B. , Ismaila Nofisat , Alluri Krishna , Florez Narjust , Gadgeel Shirish , Masters Gregory , Schenk Erin L. , Schneider Bryan J. , Sequist Lecia , Singh Navneet , Bazhenova Lyudmila , Blanchard Elizabeth , Freeman-Daily Janet , Furuya Naoki , Halmos Balazs , Azar Ibrahim Hanna , Kuruvilla Sara , Mullane Michael , Naidoo Jarushka , Reuss Joshua E. , Spigel David R. , Owen Dwight H. , Patel Jyoti D. 
Published: February 2024

Living guidelines are developed for selected topic areas with rapidly evolving evidence that drives frequent change in recommended clinical practice. Living guidelines are updated on a regular schedule by a standing expert panel that systematically reviews the health literature on a continuous basis, as described in the ASCO Guidelines Methodology Manual . ASCO Living Guidelines follow the ASCO Conflict of Interest Policy Implementation for Clinical Practice Guidelines . Living Guidelines and updates are not intended to substitute for independent professional judgment of the treating provider and do not account for individual variation among patients. See complete disclaimer in Appendix 1 and Appendix 2 for more. Updates are published regularly and can be found at https://ascopubs.org/nsclc-da-living-guideline . PURPOSE To provide evidence-based recommendations for patients with stage IV non–small cell lung cancer with driver alterations. METHODS This ASCO living guideline offers continually updated recommendations based on an ongoing systematic review of randomized clinical trials (RCTs), with the latest time frame spanning February to October 2023. An Expert Panel of medical oncology, pulmonary, community oncology, research methodology, and advocacy experts were convened. The literature search included systematic reviews, meta-analyses, and randomized controlled trials. Outcomes of interest include efficacy and safety. Expert Panel members used available evidence and informal consensus to develop evidence-based guideline recommendations. RESULTS This guideline consolidates all previous updates and reflects the body of evidence informing this guideline topic. Eight new RCTs were identified in the latest search of the literature to date. RECOMMENDATIONS Evidence-based recommendations were updated to address first, second, and subsequent treatment options for patients based on targetable driver alterations. Additional information is available at www.asco.org/living-guidelines .
Therapy for Stage IV Non–Small Cell Lung Cancer Without Driver Alterations: ASCO Living Guideline, Version 2023.3
Authors: Jaiyesimi Ishmael A. , Leighl Natasha B. , Ismaila Nofisat , Alluri Krishna , Florez Narjust , Gadgeel Shirish , Masters Gregory , Schenk Erin L. , Schneider Bryan J. , Sequist Lecia , Singh Navneet , Bazhenova Lyudmila , Blanchard Elizabeth , Freeman-Daily Janet , Furuya Naoki , Halmos Balazs , Azar Ibrahim Hanna , Kuruvilla Sara , Mullane Michael , Naidoo Jarushka , Reuss Joshua E. , Spigel David R. , Owen Dwight H. , Patel Jyoti D. 
Published: February 2024

Living guidelines are developed for selected topic areas with rapidly evolving evidence that drives frequent change in recommended clinical practice. Living guidelines are updated on a regular schedule by a standing expert panel that systematically reviews the health literature on a continuous basis, as described in the ASCO Guidelines Methodology Manual . ASCO Living Guidelines follow the ASCO Conflict of Interest Policy Implementation for Clinical Practice Guidelines . Living Guidelines and updates are not intended to substitute for independent professional judgment of the treating provider and do not account for individual variation among patients. See complete disclaimer in Appendix 1 and Appendix 2 for more. Updates are published regularly and can be found at https://ascopubs.org/nsclc-non-da-living-guideline . PURPOSE To provide evidence-based recommendations for patients with stage IV non–small cell lung cancer (NSCLC) without driver alterations. METHODS This ASCO living guideline offers continually updated recommendations based on an ongoing systematic review of randomized clinical trials (RCTs), with the latest time frame spanning February to October 2023. An Expert Panel of medical oncology, pulmonary, community oncology, research methodology, and advocacy experts were convened. The literature search included systematic reviews, meta-analyses, and randomized controlled trials. Outcomes of interest include efficacy and safety. Expert Panel members used available evidence and informal consensus to develop evidence-based guideline recommendations. RESULTS This guideline consolidates all previous updates and reflects the body of evidence informing this guideline topic. Ten new RCTs were identified in the latest search of the literature to date. RECOMMENDATIONS Evidence-based recommendations were updated to address first, second, and subsequent treatment options for patients without driver alterations. Additional information is available at www.asco.org/living-guidelines .
Plateau-Rayleigh instability of a viscous film on a soft fiber
Authors: Bharti  , Carlson Andreas , Chan Tak Shing , Salez Thomas 
Published: February 2024

Abstract
We theoretically study the Plateau-Rayleigh instability of a thin viscous film covering a fiber consisting of a rigid cylindrical core coated with a thin compressible elastic layer. We develop a soft-lubrication model, combining the capillary-driven flow in the viscous film to the elastic deformation of the soft coating, within the Winkler-foundation framework. We perform a linear-stability analysis and derive the dispersion relation. We find that the growth rate is larger when the soft coating is more compliant. As such, softness acts as a destabilising factor. In contrast, increasing the thickness of the soft coating reduces the growth rate, due to the dominating geometrical effect.
Partial- and full-tunneling processes across potential barriers
Authors: Flores Philip Caesar , Pablico Dean Alvin L. , Galapon Eric A. 
Published: February 2024

Abstract
We introduce the concept of partial-tunneling and full-tunneling processes to explain the seemingly contradictory non-zero and vanishing tunneling times often reported in the literature. Our analysis starts by considering the traversal time of a quantum particle through a potential barrier, including both above- and below-barrier traversals, using the theory of time-of-arrival operators. We then show that there are three traversal processes corresponding to non-tunneling, full tunneling, and partial tunneling. The distinction among the three depends on the support of the incident wave packet's energy distribution in relation to the shape of the barrier. Non-tunneling happens when the energy distribution of the quantum particle lies above the maximum of the potential barrier. Otherwise, full-tunneling process occurs when the energy distribution of the particle is below the minimum of the potential barrier. For this process, the obtained traversal time is interpreted as the tunneling time. Finally, the partial-tunneling process occurs when the energy distribution lies between the minimum and maximum of the potential barrier. This signifies that the quantum particle tunneled only through some portions of the potential barrier. We argue that the duration for a partial-tunneling process should not be interpreted as the tunneling time but instead as a partial traversal time to differentiate it from the full-tunneling process. We then show that a full-tunneling process is always instantaneous, while a partial-tunneling process takes a non-zero amount of time. We are then led to the hypothesis that experimentally measured non-zero and vanishing tunneling times correspond to partial- and full-tunneling processes, respectively.
HCR spectral imaging: 10-plex, quantitative, high-resolution RNA and protein imaging in highly autofluorescent samples
Authors: Schulte Samuel J. , Fornace Mark E. , Hall John K. , Shin Grace J. , Pierce Niles A. 
Published: February 2024

ABSTRACT
Signal amplification based on the mechanism of hybridization chain reaction (HCR) provides a unified framework for multiplex, quantitative, high-resolution imaging of RNA and protein targets in highly autofluorescent samples. With conventional bandpass imaging, multiplexing is typically limited to four or five targets owing to the difficulty in separating signals generated by fluorophores with overlapping spectra. Spectral imaging has offered the conceptual promise of higher levels of multiplexing, but it has been challenging to realize this potential in highly autofluorescent samples, including whole-mount vertebrate embryos. Here, we demonstrate robust HCR spectral imaging with linear unmixing, enabling simultaneous imaging of ten RNA and/or protein targets in whole-mount zebrafish embryos and mouse brain sections. Further, we demonstrate that the amplified and unmixed signal in each of the ten channels is quantitative, enabling accurate and precise relative quantitation of RNA and/or protein targets with subcellular resolution, and RNA absolute quantitation with single-molecule resolution, in the anatomical context of highly autofluorescent samples.
ESTRUTURA DE CAPITAIS EM COOPERATIVAS AGROINDUSTRIAIS DO OESTE DO PARANÁ ATRAVÉS DA VISÃO DAS TEORIAS DE PECKING ORDER E TRADE-OFF
Authors: Martins Vinicius Abilio , Kunz Alessandra , Almeida Ricardo Santana de , Dall Asta Denis 
Published: February 2024

A presente pesquisa tem como objetivo identificar a influência da estrutura de capital das cooperativas agroindustriais do oeste do Paraná nas perspectivas das teorias de Pecking Order e Trade-Off. A amostra contou com 16 cooperativas agroindustriais do oeste do Paraná, que apresentaram informações completas provenientes de Balanços Patrimoniais (BP) e Demonstrações de Resultado do Exercício (DRE) no período entre 2015 a 2019. Os resultados apresentaram que a variável Liquidez Corrente (LC) se demonstrou estatisticamente significante em todos os modelos, demonstrando ser uma variável essencial para esclarecimento dos graus de endividamento. Já a variável Crescimento das Vendas (CRESCVD), não foi possível comprovar a sua influência nos modelos devido à ausência de significância. Conclui-se que ao comparar os resultados com os preceitos das teorias Pecking Order e Trade-Off, averiguou que as cooperativas analisadas não apresentaram predominância de nenhuma teoria nos seus processos de estruturação de capital.