bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of high-frequency (5Hz) rTMS stimulating left DLPFC combined with galantamine on cognitive impairment after ischemic stroke and serum homocysteine and neuron-specific enolase
Authors: Hu Guojin , Zhang Li , Sun Xiuli , Wang Lin , Xu Qian , Li Qin , Huang Wei , Xiao Yao 
Published: February 2024

ObjectiveTo investigate the efficacy of high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) combined with galantamine in patients with cognitive impairment after stroke and its effect on serum homocysteine (Hcy) and neuron-specific enolase (NSE) levels.MethodsA total of 90 patients with cognitive impairment after the first ischemic stroke were enrolled. They were randomly divided into rTMS+ cognitive rehabilitation group, Galantamine + cognitive rehabilitation group, and rTMS+ Galantamine + cognitive rehabilitation group. All groups received routine medical treatment and limb rehabilitation treatment. The rTMS stimulation site was the left dorsolateral prefrontal cortex (left DLPFC), the magnetic stimulation frequency was 5 Hz, the magnetic stimulation intensity was 80% of the motor threshold level, and 3,000 pulses were given every day. The Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Fugl-Meyer scale, and modified Barthel index, as well as rehabilitation scale and serum NSE and Hcy were evaluated before and after treatment (after 4 weeks).ResultsAfter 4 weeks of treatment, the scores of MMSE, MoCa scale, Fugl-Meyer scale, and modified Barthel index in the three groups were significantly higher than those before treatment (all p &lt; 0.05), while the serum NSE and Hcy levels of the three groups were decreased. rTMS+ Galantamine + cognitive rehabilitation group had higher scale scores, and the difference between the three groups was statistically significant compared with the other two groups (all p &lt; 0.05).ConclusionCognitive rehabilitation combined with HF-rTMS and galantamine could improve the cognitive function of patients to the greatest extent, promote the recovery of physical activity, improve the self-care ability of daily life, and effectively reduce the serum HCY and NSE levels in patients with cognitive impairment after stroke. No randomized controlled trials of similar combination treatments have been reported. The better therapeutic effect may be related to the fact that galantamine combined with repetitive transcranial magnetism can activate the brain cholinergic system more extensively, promote brain neural remodeling through long-term potentiation and inhibit local neuroinflammatory responses in brain injury.
Factors affecting driving performance in patients with Multiple Sclerosis – still an open question
Authors: Seddiq Zai Susan , das Nair Roshan , Heesen Christoph , Buhmann Carsten , Pedersen Anya , Pöttgen Jana 
Published: February 2024

Background and objectivesResearch on driving ability in people with multiple sclerosis (MS) suggests that they might be at risk for unsafe driving due to MS-related motor, visual, and cognitive impairment. Our first aim was to investigate differences in driving ability and performance between people with MS (PwMS) and those without any neurologic or psychiatric disease (“controls”). Secondly, we determined disease-related factors influencing driving ability in PwMS.MethodsWe prospectively compared standardized performance in a driving simulator between 97 persons with early MS [mean (SD) = 6.4 (7.3) years since diagnosis, mean (SD) Expanded Disability Status Scale (EDSS) = 2.5 (1.4)] and 94 group-matched controls. Participants completed an extensive examination comprising questionnaires and assessments regarding driving, cognitive and psychological factors, as well as demographic and disease-related measures. Between-group comparisons of driving-relevant neuropsychological tests and driving performance were done. Correlations were performed to define demographic and disease-related factors on driving performance in MS.ResultsIn a driving simulator setting, PwMS had more driving accidents [T(188) = 2.762, p = 0.006], reacted slower to hazardous events [T(188) = 2.561, p = 0.011], made more driving errors [T(188) = 2.883, p = 0.004] and had a worse Driving Safety Score (DSS) [T(188) = 3.058, p = 0.003] than controls. The only disease-related measure to be associated with most driving outcomes was the Wechsler Block-Tapping test (WMS-R) backward: number of accidents (r = 0.28, p = 0.01), number of driving errors (r = 0.23, p = 0.05) and DSS (r = −0.23, p = 0.05).ConclusionDriving performance in a simulator seems to be reduced in PwMS at an early stage of disease compared to controls, as a result of increased erroneous driving, reduced reaction time and higher accident rate. MS-related impairment in mobility, vision, cognition, and in psychological and demographic aspects showed no or only minimal association to driving ability, but impairment in different areas of cognition such as spatial short-term memory, working memory and selective attention correlated with the number of accidents, and might indicate a higher risk for driving errors and worse performance. These results show that driving ability is a complex skill with involvement of many different domains, which need further research.
Active recharge biphasic stimulation for the intraoperative monopolar review in deep brain stimulation
Authors: Mampre David , Kim Min Jae , Oliver Tucker , Sorrentino Zachary , Chandra Vyshak , Christie Carlton , Zakare-Fagbamila Rasheedat , Hilliard Justin D. , Wong Joshua K. 
Published: February 2024

IntroductionCharge balancing is used in deep brain stimulation (DBS) to avoid net charge accumulation at the tissue-electrode interface that can result in neural damage. Charge balancing paradigms include passive recharge and active recharge. In passive recharge, each cathodic pulse is accompanied by a waiting period before the next stimulation, whereas active recharge uses energy to deliver symmetric anodic and cathodic stimulation pulses sequentially, producing a net zero charge. We sought to determine differences in stimulation induced side effect thresholds between active vs. passive recharge during the intraoperative monopolar review.MethodsSixty-five consecutive patients undergoing DBS from 2021 to 2022 were retrospectively reviewed. Intraoperative monopolar review was performed with both active recharge and passive recharge for all included patients to determine side effect stimulation thresholds. Sixteen patients with 64 total DBS contacts met inclusion criteria for further analysis. Intraoperative monopolar review results were compared with the monopolar review from the first DBS programming visit.ResultsThe mean intraoperative active recharge stimulation threshold was 4.1 mA, while the mean intraoperative passive recharge stimulation threshold was 3.9 mA, though this difference was not statistically significant on t-test (p = 0.442). Mean stimulation threshold at clinic follow-up was 3.2 mA. In Pearson correlation, intraoperative passive recharge thresholds had stronger correlation with follow-up stimulation thresholds (Pearson r = 0.5281, p &lt; 0.001) than intraoperative active recharge (Pearson r = 0.340, p = 0.018), however the difference between these correlations was not statistically significant on Fisher Z correlation test (p = 0.294). The mean difference between intraoperative passive recharge stimulation threshold and follow-up stimulation threshold was 0.8 mA, while the mean difference between intraoperative active recharge threshold and follow-up threshold was 1.2 mA. This difference was not statistically significant on a t-test (p = 0.134).ConclusionsBoth intraoperative active recharge and passive recharge stimulation were well-correlated with the monopolar review at the first programming visit. No statistically significant differences were observed suggesting that either passive or active recharge may be utilized intraoperatively.
Anatomical variations of the atlas arches: prevalence assessment, systematic review and proposition for an updated classification system
Authors: Baena-Caldas Gloria P. , Mier-García Juan F. , Griswold Dylan P. , Herrera-Rubio Adriana M. , Peckham Ximara 
Published: February 2024

Objective and backgroundThis study focuses on the atlas, a pivotal component of the craniovertebral junction, bridging the cranium and spinal column. Notably, variations in its arches are documented globally, necessitating a thorough assessment and categorization due to their significant implications in clinical, diagnostic, functional, and therapeutic contexts. The primary objective is to ascertain the frequency of these anatomical deviations in the atlas arches among a Colombian cohort using cone-beam computed tomography (CBCT).MethodologyEmploying a descriptive, cross-sectional approach, this research scrutinizes the structural intricacies of the atlas arches in CBCT scans. Analytical parameters included sex distribution and the nature of anatomical deviations as per Currarino’s classification. Statistical analyses were conducted to identify significant differences, including descriptive statistics and Chi-square tests. A systematic review of the literature was conducted in order to enhance the current Currarino’s classification.ResultsThe study examined 839 CBCT images, with a nearly equal sex distribution (49.7% female, 50.3% male). Anatomical variations were identified in 26 instances (3%), displaying a higher incidence in females (X2 [(1, N = 839) = 4.0933, p = 0.0430]). The most prevalent variation was Type A (2.5%), followed by Type B (0.4%), and Type G (0.2%) without documenting any other variation. The systematic review yielded 7 studies. A novel classification system for these variations is proposed, considering global prevalence data in the cervical region.ConclusionThe study highlights a statistically significant predominance of Type A variations in the female subset. Given the critical nature of the craniovertebral junction and supporting evidence, it recommends an amendment to Currarino’s classification to better reflect these clinical observations. A thorough study of anatomical variations of the upper cervical spine is relevant as they can impact important functional aspects such as mobility as well as stability. Considering the intricate anatomy of this area and the pivotal function of the atlas, accurately categorizing the variations of its arches is crucial for clinical practice. This classification aids in diagnosis, surgical planning, preventing iatrogenic incidents, and designing rehabilitation strategies.
Make me more comfortable: effects of a hypnosis session on pain perception in chronic pain patients
Authors: Ogez David , Landry Mathieu , Caron-Trahan Rémi , Jusseaux Anne-Eva , Aubin Maryse , Véronneau Jade , Fournier Valentyn , Godin Nadia , Idrissi Moulay , Rainville Pierre , Richebé Philippe 
Published: February 2024

IntroductionApproximately one-quarter of Canadians experience chronic pain, a debilitating condition often necessitating opioid use, which raises concerns regarding dependency and overdose risks. As an alternative, we developed the HYlaDO program (Hypnose de la Douleur, hypnosis of Pain in French), a novel self-hypnosis approach for chronic pain management. The development of this program followed the ORBIT model, a comprehensive framework for designing interventions encompassing several phases ranging from design to efficacy assessment.MethodsIn the present work, we conducted a preliminary evaluation of the HYlaDO program with 21 participants (18 of the 21 patients were included in the analysis). The primary objective was to determine one session of the program’s effectiveness in altering pain, anxiety and relaxation via pre-post analysis. The secondary goal was to examine the long-term effects across the same measures, in addition to the overall quality of life.ResultsThe results highlight the benefits of our approach, while participants reported short-term significant pain reduction, decreased anxiety, and increased relaxation. Additionally, preliminary trends suggest improvements in physical activity and quality of life metrics.DiscussionThese positive outcomes highlight HYlaDO’s potential as an alternative to opioid therapy for chronic pain. Encouraged by these results, we aim to extend our research to a broader and more diverse cohort, paving the way for comprehensive randomized controlled trials. This expansion will further validate HYlaDO’s efficacy and its role in transforming chronic pain management.
Application study of multidisciplinary collaboration (MDT) integrated management model in perioperative management of patients with infectious nonunion
Authors: Lu Qing , Bi Zhaodong , Tian Yunxu , Li Yuqing , Zhang Shanshan , Li Xiuting , Xing Wenzhao 
Published: February 2024

ObjectiveTo explore the effectiveness of a multidisciplinary treatment (MDT) integrated intervention model in the perioperative management of patients with infectious nonunion.Methods80 patients with infectious bone defects treated in our hospital from January 2020 to January 2023 were selected. They were classified into MDT-integrated perioperative group (study group) and conventional control group according to the different management patterns, with 40 cases each. The incidence of wound infection, pin tract infection, delayed bone healing, deep vein thrombosis (DVT), joint stiffness, and nutritional indicators were compared between the two groups.ResultsThe rates of wound infection (P = 0.042), pin tract infection of Grade II or above (P = 0.006), delayed bone healing (P = 0.006), DVT (P = 0.033), and joint stiffness (P = 0.023) in the MDT integrated perioperative (study) group were significantly lower than those in the conventional care group (P &lt; 0.05). With the extension of intervention time, the changes in body weight, levels of serum albumin (ALB), pre-albumin (PA), hemoglobin (Hb), and serum sodium (Na) in the study group were higher than those in the conventional care group (P &lt; 0.05).ConclusionThe application of the MDT integrated intervention model in the perioperative period of patients with infectious nonunion is beneficial in reducing the risks of wound infection and pin tract infection of Grade II or above, lowering the incidence rates of lower limb DVT and joint stiffness, and reducing the risk of malnutrition, demonstrating high clinical application value.
Use of in vitro methods combined with in silico analysis to identify potential skin sensitizers in the Tox21 10K compound library
Authors: Wei Zhengxi , Xu Tuan , Strickland Judy , Zhang Li , Fang Yuhong , Tao Dingyin , Simeonov Anton , Huang Ruili , Kleinstreuer Nicole C. , Xia Menghang 
Published: February 2024

Introduction: Skin sensitization, which leads to allergic contact dermatitis, is a key toxicological endpoint with high occupational and consumer prevalence. This study optimized several in vitro assays listed in OECD skin sensitization test guidelines for use on a quantitative high-throughput screening (qHTS) platform and performed in silico model predictions to assess the skin sensitization potential of prioritized compounds from the Tox21 10K compound library.Methods: First, we screened the entire Tox21 10K compound library using a qHTS KeratinoSensTM (KS) assay and built a quantitative structure–activity relationship (QSAR) model based on the KS results. From the qHTS KS screening results, we prioritized 288 compounds to cover a wide range of structural chemotypes and tested them in the solid phase extraction–tandem mass spectrometry (SPE–MS/MS) direct peptide reactivity assay (DPRA), IL-8 homogeneous time-resolved fluorescence (HTRF) assay, CD86 and CD54 surface expression in THP1 cells, and predicted in silico sensitization potential using the OECD QSAR Toolbox (v4.5).Results: Interpreting tiered qHTS datasets using a defined approach showed the effectiveness and efficiency of in vitro methods. We selected structural chemotypes to present this diverse chemical collection and to explore previously unidentified structural contributions to sensitization potential.Discussion: Here, we provide a skin sensitization dataset of unprecedented size, along with associated tools, and analysis designed to support chemical assessments.
A Novel Postbiotic Product Based on Weissella cibaria for Enhancing Disease Resistance in Rainbow Trout: Aquaculture Application
Authors: Quintanilla-Pineda Mario , Ibañez Francisco C. , Garrote-Achou Chajira , Marzo Florencio 
Published: February 2024

Postbiotics are innovative tools in animal husbandry, providing eco-friendly solutions for disease management within the industry. In this study, a new postbiotic product was evaluated for its impact on the health of rainbow trout (Oncorhynchus mykiss). In vivo studies were conducted to assess the safety of the Weissella cibaria strains used in postbiotic production. Additionally, this study evaluated the impact of diet supplementation with 0.50% postbiotics on growth performance during a 30-day feeding trial; the gut microbial communities, immunomodulation, and protection against Yersinia ruckeri infection were evaluated. The strains did not harm the animals during the 20-day observation period. Furthermore, the effect of postbiotics on growth performance was not significant (p < 0.05). The treated group showed a significant increase in acid-lactic bacteria on the 30th day of the feeding trial, with counts of 3.42 ± 0.21 log CFU/mL. Additionally, there was an up-regulation of the pro-inflammatory cytokine IL-1β in head kidney samples after 48 h of feed supplementation, whereas cytokines IL-10, IL-8, INF-γ, and TNF-α were down-regulated. The findings indicate that rainbow trout fed with postbiotics saw an improvement in their survival rate against Y. ruckeri, with a 20.66% survival improvement in the treated group. This study proves that incorporating postbiotics from two strains of W. cibaria previously isolated from rainbow trout into the diet of fish has immunomodulatory effects, enhances intestinal microbial composition, and improves fish resistance against Y. ruckeri.
PENGARUH UKURAN PERUSAHAAN, KONSENTRASI KEPEMILIKAN, DAN KOMISARIS INDEPENDEN TERHADAP PENGUNGKAPAN INTELLECTUAL CAPITAL
Authors: Setiawan Faysa Adityar , Suzan Leny 
Published: February 2024

Kontrak antara manajemen dan karyawan sekarang diatur oleh jenis komunikasi baru yang dikenal sebagai pengungkapan intellectual capital. Hal ini memungkinkan manajer untuk mengembangkan strategi untuk memenuhi tuntutan pemangku kepentingan seperti investor, dan untuk meyakinkan mereka tentang manfaat atau keuntungan dari kebijakan perusahaan. Pengungkapan intellectual capital merupakan informasi yang diberikan oleh perusahaan tentang pengelolaan dan pemanfaatan atas intellectual capital yang dimiliki. Pengungkapan intellectual capital perlu dilakukan karena dapat mengurangi asimetri informasi yang terjadi pada manajemen dan stakeholder. Bertujuan untuk mengetahui apakah ukuran perusahaan, konsentrasi kepemilikan, dan komisaris independen berpengaruh terhadap pengungkapan modal intelektual pada perusahaan LQ45 yang terdaftar di Bursa Efek Indonesia periode 2018-2021. Teknik analisis data dalam penelitian ini menggunakan model regresi data panel. Hasil Penelitian menunjukkan bahwa ukuran perusahaan, konsentrasi kepemilikan, dan komisaris independen secara simultan berpengaruh terhadap pengungkapan intellectual capital. Sedangkan secara parsial, konsentrasi kepemilikan berpengaruh terhadap pengungkapan intellectual capital. Ukuran perusahaan dan komisaris independen tidak mempengaruhi pengungkapan intellectual capital.
KEPEMIMPINAN TRANSFORMASIONAL GENERASI MILENIAL DALAM MENGHADAPI KESENJANGAN LINTAS GENERASI DI PERUSAHAAN BLUE EKONOMI JAWA TIMUR
Authors: Kent Mario , Noviaty Kresna Darmasetiawan  
Published: February 2024

Abstract. This research discusses the role of generations (Baby Boomers, Generation X, and Millennials) in the Blue Economy industry in Indonesia. The main challenge for leaders is managing generational and work culture differences. The research results show that Millennial leaders have three basic characteristics of leadership behavior, such as communicating a clear vision, building trust, and respecting others. However, these characteristics are not enough to overcome cross-generational challenges and work culture in Indonesia. Therefore, leaders need to develop adaptability, generational understanding, and self-control. The research was conducted at PT. X in Probolinggo with qualitative methods and a case study approach.effects. This research uses a qualitative approach with resource persons taking high-level decisions (directors, General Managers, or owners) as interview subjects. Data was collected through purposive sampling, including in-depth interviews, observation and documentation. Confirmation data was obtained through interviews with employees, visitors, and document analysis..

Abstrak. Penelitian ini membahas peran generasi (Baby Boomer, Generasi X, dan Millennial) dalam industri Blue Economy di Indonesia. Tantangan utama bagi pemimpin adalah mengelola perbedaan generasi dan budaya kerja. Hasil penelitian menunjukkan bahwa pemimpin Millennial memiliki tiga karakteristik dasar leadership behavior, seperti komunikasi visi yang jelas, membangun kepercayaan, dan menghormati orang lain. Namun, karakteristik ini belum cukup untuk mengatasi tantangan lintas generasi dan budaya kerja di Indonesia. Oleh karena itu, pemimpin perlu mengembangkan kemampuan adaptasi, pemahaman generasi, dan kendali diri. Penelitian dilakukan di PT. X di Probolinggo dengan metode kualitatif dan pendekatan studi kasus.efek. Penelitian ini menggunakan pendekatan kualitatif dengan narasumber pengambil keputusan tingkat tinggi (direktur, General Manager, atau pemilik) sebagai subjek wawancara. Data dikumpulkan melalui purposive sampling, termasuk wawancara mendalam, observasi, dan dokumentasi. Konfirmasi data diperoleh melalui wawancara dengan karyawan, pengunjung, dan analisis dokumen.
THE OPTIMUM DECISION OF OIL AND GAS PRODUCTION SPREADSHEET MODELLING
Authors: Winarto Rudy , Dinariyana Anak Agung Bagus 
Published: February 2024

The optimum revenue of an oil and gas industry is subject to the production volume deliverability and relatively volatile product market price which depends on demand and supply level. Naturally, mature production wells will be dominantly producing water instead of oil and gas, meanwhile, the central processing facilities are having their limited capacity to handle it. This study intends to gain the optimum oil and gas production in mature fields by deciding the opening of well choke valves and considering process facilities limitations as constraints. The model is developed using a simplex LP-based spreadsheet. Three wellhead facilities with a total of forty-seven active producing wells gas, oil, and water data are taken as input parameters. The developed model is validated using the last ten days’ actual production data to identify the error margin consistency, a total of 1,410 data combinations were used. It results in an average error margin of 4.57%-gas and 0.9%-oil. The model could be used as an operator decision reference in opening the well’s choke valve to get the optimum production rate, a minor adjustment might need considering the dynamic process parameter condition.

Keywords: optimal production, mature wells, choke valve opening, spreadsheet modeling