bluuebunny/crossref_metadata_2025_split huggingface dataset:
Direct Laser Processing and Functionalizing PI/PDMS Composites for an On‐Demand, Programmable, Recyclable Device Platform
Authors: Zhu Jia , Xiao Yang , Zhang Xianzhe , Tong Yao , Li Jiaying , Meng Ke , Zhang Yingying , Li Jiuqiang , Xing Chenghao , Zhang Senhao , Bao Benkun , Yang Hongbo , Gao Min , Pan Taisong , Liu Shangbin , Lorestani Farnaz , Cheng Huanyu , Lin Yuan 
Published: April 2024

AbstractSkin‐interfaced high‐sensitive biosensing systems to detect electrophysiological and biochemical signals have shown great potential in personal health monitoring and disease management. However, the integration of 3D porous nanostructures for improved sensitivity and various functional composites for signal transduction/processing/transmission often relies on different materials and complex fabrication processes, leading to weak interfaces prone to failure upon fatigue or mechanical deformations. The integrated system also needs additional adhesive to strongly conform to the human skin, which can also cause irritation, alignment issues, and motion artifacts. This work introduces a skin‐attachable, reprogrammable, multifunctional, adhesive device patch fabricated by simple and low‐cost laser scribing of an adhesive composite with polyimide powders and amine‐based ethoxylated polyethylenimine dispersed in the silicone elastomer. The obtained laser‐induced graphene in the adhesive composite can be further selectively functionalized with conductive nanomaterials or enzymes for enhanced electrical conductivity or selective sensing of various sweat biomarkers. The possible combination of the sensors for real‐time biofluid analysis and electrophysiological signal monitoring with RF energy harvesting and communication promises a standalone stretchable adhesive device platform based on the same material system and fabrication process.
In Situ Chemical Modulation of Graphitization Degree of Carbon Fibers and Its Potassium Storage Mechanism
Authors: Xiong Shuangsheng , Wu Qi , Gao Yuan , Li Zhiping , Wang Chen , Wang Shuo , Li Zheng , Hou Li , Gao Faming 
Published: April 2024

AbstractGraphite is considered to be the most auspicious anode candidate for potassium ion batteries. However, the inferior rate performances and cycling stability restrict its practical applications. Few studies have investigated the modulating the graphitization degree of graphitic materials. Herein, a nitrogen‐doped carbon‐coated carbon fiber composite with tunable graphitization (CNF@NC) through etching growth, in‐situ oxidative polymerization, and subsequent carbonization process is reported. The prepared CNF@NC with abundant electrochemical active sites and a rapid K+/electron transfer pathway, can effectively shorten the K+ transfer distance and promote the rapid insertion/removal of K+. Amorphous domains and short‐range curved graphite layers can provide ample mitigation spaces for K+ storage, alleviating the volume expansion of the highly graphitized CNF during repeated K+ insertion/de‐intercalation. As expected, the CNF@NC‐5 electrode presents a high initial coulombic efficiency (ICE) of 69.3%, an unprecedented reversible volumetric capacity of 510.2 mA h cm−3 at 0.1 A g−1 after 100 cycles with the mass‐capacity of 294.9 mA h g−1. The K+ storage mechanism and reaction kinetic analysis are studied by combining in‐situ analysis and first‐principles calculation. It manifests that the K+ storage mechanism in CNF@NC‐5 is an adsorption‐insertion‐insertion mechanism (i.e., the “1+2” model). The solid electrolyte interphase (SEI) film forming is also detected.
Involvement of the JAK‐STAT pathway in the molecular landscape of tyrosine kinase fusion‐negative hypereosinophilic syndromes: A nationwide CEREO study
Authors: Groh Matthieu , Fenwarth Laurène , Labro Mathilde , Boudry Augustin , Fournier Elise , Wemeau Mathieu , Marceau‐Renaut Alice , Daltro de Oliveira Rafael , Abraham Julie , Barry Marly , Blanche Philippe , Bodard Quentin , Braun Thorsten , Chebrek Safia , Decamp Matthieu , Durel Cécile‐Audrey , Forcade Edouard , Gerfaud‐Valentin Mathieu , Golfier Camille , Gourguechon Clément , Grardel Nathalie , Kosmider Olivier , Martis Nihal , Melboucy Belkhir Sarah , Merabet Fatiha , Michon Adrien , Moreau Stéphane , Morice Cécile , Néel Antoine , Nicolini Franck E. , Pascal Laurent , Pasquier Florence , Pieragostini Andrea , Roche‐Lestienne Catherine , Rousselot Philippe , Terriou Louis , Thiebaut‐Bertrand Anne , Viallard Jean‐François , Preudhomme Claude , Kahn Jean‐Emmanuel , Lefevre Guillaume , Duployez Nicolas ,   CEREO Collaborators
Published: April 2024

AbstractWe investigated using a custom NGS panel of 149 genes the mutational landscape of 64 consecutive adult patients with tyrosine kinase fusion‐negative hypereosinophilia (HE)/hypereosinophilic syndrome (HES) harboring features suggestive of myeloid neoplasm. At least one mutation was reported in 50/64 (78%) patients (compared to 8/44 (18%) patients with idiopathic HE/HES/HEUS used as controls; p < .001). Thirty‐five patients (54%) had at least one mutation involving the JAK‐STAT pathway, including STAT5B (n = 18, among which the hotspot N642H, n = 13), JAK1 (indels in exon 13, n = 5; V658F/L, n = 2), and JAK2 (V617F, n = 6; indels in exon 13, n = 2). Other previously undescribed somatic mutations were also found in JAK2, JAK1, STAT5B, and STAT5A, including three patients who shared the same STAT5A V707fs mutation and features consistent with primary polycythemia. Nearly all JAK‐STAT mutations were preceded by (or associated with) myelodysplasia‐related gene mutations, especially in RNA‐splicing genes or chromatin modifiers. In multivariate analysis, neurologic involvement (hazard ratio [HR] 4.95 [1.87–13.13]; p = .001), anemia (HR 5.50 [2.24–13.49]; p < .001), and the presence of a high‐risk mutation (as per the molecular international prognosis scoring system: HR 6.87 [2.39–19.72]; p < .001) were independently associated with impaired overall survival. While corticosteroids were ineffective in all treated JAK‐STAT‐mutated patients, ruxolitinib showed positive hematological responses including in STAT5A‐mutated patients. These findings emphasize the usefulness of NGS for the workup of tyrosine kinase fusion‐negative HE/HES patients and support the use of JAK inhibitors in this setting. Updated classifications could consider patients with JAK‐STAT mutations and eosinophilia as a new “gene mutated‐entity” that could be differentiated from CEL, NOS, and idiopathic HES.
On the effect heterogeneity of established disease susceptibility loci for Alzheimer's disease across different genetic ancestries
Authors: Lee Sanghun , Hecker Julian , Hahn Georg , Mullin Kristina ,   Alzheimer's Disease Neuroimaging Initiative (ADNI), Lutz Sharon M. , Tanzi Rudolph E. , Lange Christoph , Prokopenko Dmitry 
Published: April 2024

AbstractINTRODUCTIONGenome‐wide association studies have identified numerous disease susceptibility loci (DSLs) for Alzheimer's disease (AD). However, only a limited number of studies have investigated the dependence of the genetic effect size of established DSLs on genetic ancestry.METHODSWe utilized the whole genome sequencing data from the Alzheimer's Disease Sequencing Project (ADSP) including 35,569 participants. A total of 25,459 subjects in four distinct populations (African ancestry, non‐Hispanic White, admixed Hispanic, and Asian) were analyzed.RESULTSWe found that nine DSLs showed significant heterogeneity across populations. Single nucleotide polymorphism (SNP) rs2075650 in translocase of outer mitochondrial membrane 40 (TOMM40) showed the largest heterogeneity (Cochran's Q = 0.00, I2 = 90.08), followed by other SNPs in apolipoprotein C1 (APOC1) and apolipoprotein E (APOE). Two additional loci, signal‐induced proliferation‐associated 1 like 2 (SIPA1L2) and solute carrier 24 member 4 (SLC24A4), showed significant heterogeneity across populations.DISCUSSIONWe observed substantial heterogeneity for the APOE‐harboring 19q13.32 region with TOMM40/APOE/APOC1 genes. The largest risk effect was seen among African Americans, while Asians showed a surprisingly small risk effect.
Modified Halloysite as Catalyst for the Conversion of Hydroxymethylfurfural to Furandicarboxylic Acid: A DFT Investigation
Authors: Bertini Marco , Ferrante Francesco , Guercio Ludovico , Lisuzzo Lorenzo , Duca Dario 
Published: April 2024

AbstractThe reaction steps involved in the 5‐hydroxymethylfurfural to 2,5‐furandicarboxylic acid conversion by means of H2O2 were investigated employing a dedicated computational protocol based on density functional theory. The catalytic environment of choice was a molecular model representing a portion of the halloysite nanotube outer surface, functionalized by an organosilane, the 3‐aminopropyltriethoxysilane, whose amino group bonds one gold atom. At this stage of the investigation, the process was fully detailed in terms of the interactions between the reaction intermediates and the catalyst, and the reaction standard free energies. In addition, the energy barriers of the elementary steps involving the hydrogen migration from the adsorbed organic species to the gold atom were analyzed. On the basis of the interaction geometries, a certain distinction among the preferred reaction path can be inferred as a function of the net negative charge characterizing the catalyst outer surface. Since the inner surface of halloysite can represent the acid environment needed to obtain 5‐hydroxymethylfurfural through dehydration of fructose, the present study is framed in a wider research field where the possibility to consider functionalized halloysite as one‐pot reactor for the valorization of biomass is explored.
Construction of Co1‐xZnxFe2xGa2–2xO4 (0<x≤0.6) Solid Solutions for Improving Solar Fuels Production in Photocatalytic CO2 Reduction by H2O Vapour
Authors: Wang Qiang , Li Li , Lu Jiaxue , Chai Yao , Shen Jinni , Liang Jun 
Published: April 2024

AbstractSolid solutions are garnering substantial attention in the realm of solar energy utilization due to their tunable electronic properties, encompassing band edge positions and charge‐carrier mobilities. In this study, we designed and synthesized Co1‐xZnxFe2xGa2–2xO4 (0<x≤0.6) as a photocatalyst for CO2 conversion using H2O. Careful optical and photo/electrochemical characterizations unveiled that the relative content of CoGa2O4 and ZnFe2O4 not only substantially influences light absorption in the full solar spectrum but also modulates valence and conduction band positions. We thoroughly assessed the photocatalytic activity of Co1‐xZnxFe2xGa2–2xO4 and found that when x=0.35, the solid‐solution catalyst achieved a remarkable CO2 reduction rate to CH4 and CO (31.5 μmol g−1 h−1). Furthermore, this optimized solid‐solution catalyst demonstrated impressive photostability. Characterization and DFT calculations revealed that the formation of a solid solution not only reduces the band gap and promotes the separation of electron‐hole pairs to accelerate efficient CO2 photoreduction, but also the introduction of more FeO6 octahedral active sites in Co1‐xZnxFe2xGa2–2xO4 solid solutions enhanced the effective photoreduction of CO2. This design results in high conversion efficiencies for producing solar fuels through CO2 reduction with H2O.
Relationship between 24 h blood pressure variability and mortality in acute myocardial infarction patients
Authors: Liu Ying , Li Wen , An Shuoyan , Zhai Zhengqin , Liu Xinju , Hei Mengxue , Chen Gailing 
Published: April 2024

AbstractBackgroundIn recent years, the mortality of patients with AMI has not declined significantly. The relationship between blood pressure variability (BPV) and acute myocardial infarction (AMI) is unclear. We explored the relationship between 24‐h BPV and mortality in patients with AMI.HypothesisThe mortality of patients with AMI is related to BPV. We hope to provide therapeutic ideas for reducing the risk of death in patients with AMI.MethodsThis is a retrospective cohort study. We extracted and analyzed data from the MIMIC‐IV 2.0, which was established in 1999 under the auspices of the National Institutes of Health (America). The average real variability (ARV) was calculated for the first 24‐h blood pressure measurement after patients with AMI were admitted to the intensive care unit (ICU). Patients were divided into four groups according to ARV quartiles. The outcomes were 30‐day, 1‐year, and 3‐year all‐cause mortalities. Data were analyzed using Cox regression, Kaplan–Meier curves, and restricted cubic spline (RCS) curves.ResultsWe enrolled 1291 patients with AMI, including 475 female. The patients were divided into four groups according to the qualities of diastolic blood pressure (DBP)‐ARV. There were significant differences in the 30‐day, 1‐year and 3‐year mortality among the four groups (p = .02, p < .001, p < .001, respectively). After adjustment for confounding factors, systolic blood pressure (SBP)‐ARV could not predict AMI patient mortality (p > .05), while the highest DBP‐ARV was associated strongly with increased 30‐day mortality (HR: 2.291, 95% CI 1.260‐4.168), 1‐year mortality (HR: 1.933, 95% CI 1.316‐2.840) and 3‐year mortality (HR: 1.743, 95% CI 1.235‐2.461). Kaplan–Meier curves demonstrated that, regardless of SBP or DBP, the long‐term survival probabilities of patients in the highest ARV group were significantly lower than that of those in other groups. RCS curves showed that the death risk of patients with AMI first decreased and then increased with the increase in ARV when DBP‐ARV < 8.04. The 30‐day death risk first increased and then decreased, and the 1‐year and 3‐year death risks increased and then stabilized with ARV increase when DBP‐ARV > 8.04.ConclusionThis study showed that patients with AMI may have an increased risk of short‐ and long‐term death if their DBP‐ARV is higher or lower during the first 24‐h in ICU.
Electronic health intervention to manage symptoms of immunotherapy in patients with cancer (SOFIA): Results from a randomized controlled pilot trial
Authors: Sauer Christina , Zschäbitz Stefanie , Krauss Jürgen , Walle Thomas , Haag Georg Martin , Jäger Dirk , Hiller Kiriaki , Bugaj Till Johannes , Friederich Hans‐Christoph , Maatouk Imad 
Published: April 2024

AbstractBackgroundFor patients receiving immune checkpoint inhibitors, early detection of immune‐related adverse events (irAEs) is critical for one’s safety. To this end, a smartphone app (SOFIA) was developed that featured the assessment of electronic patient‐reported outcomes (ePROs) focusing on irAEs as well as a set of comprehensive supportive information. Its feasibility and preliminary efficacy were evaluated in a randomized controlled trial (RCT).MethodsPatients who received immune checkpoint inhibition therapy were randomly assigned to an intervention group (IG) or a control group (CG; care as usual). During the 12‐week intervention period, IG patients used SOFIA to report twice weekly ePROs and receive cancer‐ and immunotherapy‐relevant contents. Before a patient’s next clinical visit, the physician in charge was given the ePRO reports. The primary objective was to test the feasibility of SOFIA. Furthermore, the preliminary efficacy of SOFIA for health‐related quality of life (HRQOL), psychosocial outcomes, and medical data was examined. Clinical outcomes were assessed at baseline (T0), post‐intervention (T1), and a 3‐month follow‐up (T2).ResultsSeventy‐one patients were randomized to the IG (n = 34) or the CG (n = 37). SOFIA showed high feasibility and acceptance. At T1, patients in the IG reported significantly better HRQOL and role functioning and less depression, distress, and appetite loss. No significant differences were revealed regarding medical data, the utilization of supportive care services, or survival.ConclusionsSOFIA showed high feasibility and acceptance and improved HRQOL and psychosocial outcomes. These results suggest further evaluation of efficacy in a large‐scale confirmatory multicenter RCT.
MB16− (M=Sc, Y, La): Perfect Bowl‐Like Boron Clusters
Authors: Dong Xue , Miao Lin‐Hong , Liu Yu‐Qian , Cui Li‐Juan , Feng Wei , Cui Zhong‐Hua 
Published: April 2024

AbstractThe introduction of transition‐metal doping has engendered a remarkable array of unprecedented boron motifs characterized by distinctive geometries and bonding, particularly those heretofore unobserved in pure boron clusters. In this study, we present a perfect (no defects) boron framework manifesting an inherently high‐symmetry, bowl‐like architecture, denoted as MB16− (M=Sc, Y, La). In MB16−, the B16 is coordinated to M atoms along the C5v‐symmetry axis. The bowl‐shaped MB16− structure is predicted to be the lowest‐energy structure with superior stability, owing to its concentric (2 π+10 π) dual π aromaticity. Notably, the C5v‐symmetry bowl‐like B16− is profoundly stabilized through the doping of an M atom, facilitated by strong d‐pπ interactions between M and boron motifs, in conjunction with additional electrostatic stabilization by an electron transfer from M to the boron motifs. This concerted interplay of covalent and electrostatic interactions between M and bowl‐like B16 renders MB16− a species of exceptional thermodynamic stability, thus making it a viable candidate for gas‐phase experimental detection.
Ether−Water Co‐Solvent Electrolytes Enhanced Vanadium Oxide Cathode Cyclic Behaviors for Zinc Batteries
Authors: Li Linpo , Jiang Gang , Li Mengxiang , Xu Mingyang , Wang Liyuan , Li Jing , Wang Mingyu , Shangguan Enbo , Niu Yanli 
Published: April 2024

AbstractVanadium‐based compounds are fantastic cathodes for aqueous zinc metal batteries due to the high specific capacity and excellent rate capability. Nevertheless, the practical application has been hampered by the dissolution of vanadium in traditional aqueous electrolytes owing to the strong polarity of water molecules. Herein, we propose a hybrid electrolyte made of Zn(ClO4)2 salt in tetraethylene glycol dimethyl ether (G4) and H2O solvents to upgrade the cycle life of Zn//K0.486V2O5 battery. The G4 jointly solvates with Zn2+ ions and replaces a portion of the H2O molecules in the Zn2+ solvation sheath. It forms a strong bond with H2O, reducing its activity, and significantly inhibiting vanadium dissolution and water‐induced parasitic reaction. Consequently, the optimized electrolyte with H2O and G4 volume ratio of 5 : 5 enhances the cycling stability of Zn//K0.486V2O5 battery, enabling it to reach up to 600 cycles. In addition, the battery demonstrates a satisfactory reversible capacity of 475.7 mAh g−1 and excellent rate performance attributed to the moderate ionic conductivity (28.8 mS cm−1) of the hybrid electrolyte. Last but not least, in the optimized electrolyte, the symmetric Zn//Zn cells deliver a long cycling performance of 400 h, while the asymmetric Zn//Cu cells shows a high average coulombic efficiency of 97.4 %.
Implementation of an adaptive control approach in a single‐phase grid‐tied solar photovoltaic system for power quality improvement
Authors: Singh Sukhbir , Rai Jitendra Nath 
Published: April 2024

SummaryThis work focuses on a novel single‐phase complex band‐pass filter‐based frequency‐locked loop (1ϕ‐CBF‐FLL) control for a grid‐tied solar photovoltaic array (SPVA)‐based energy generating system. Among the novel characteristics of this 1ϕ‐CBF‐FLL control algorithm are as follows: (1) It offers a quick convergence rate; (2) it has the ability to mitigate harmonics and DC offset; and (3) it has simplicity in execution. A voltage source converter (VSC), boost converter, 1‐ϕ grid, ripple filter, and nonlinear loads are all part of the system. Feeding 1‐ϕ nonlinear loads and the grid with active power from the solar array is managed by the VSC. Furthermore, grid current quality is enhanced by the use of VSC. Between the solar array and DC‐link capacitor, there is a boost converter that uses the perturb and observe (P&O) technique to track the maximum power from the SPVA. The primary aim of the proposed system is to remove power quality (PQ) issues brought on by nonlinear and imbalanced loads and to supply sinusoidal grid currents during solar irradiance fluctuations. Additionally, a comparison between 1ϕ‐CBF‐FLL control and other control algorithms is presented. The effectiveness of this 1ϕ‐CBF‐FLL control is examined under varying nonlinear loads and in various environmental settings. Test results are used to confirm the simulated results of the proposed system. According to the IEEE‐519 standard, the recommended control may achieve a source current of total harmonic distortion (THD) of 4.02%, which is lower than 5%, a source voltage of THD of 3.21%, and a load current of THD of 24.54%.
Studies on the spatial evolution of pulsed helium plasma
Authors: Singha S. , Ahmed A. , Borthakur S. , Neog N. K. , Borthakur T. K. 
Published: April 2024

AbstractThe high‐density transient plasma, streaming from a pulsed plasma accelerator (PPA), was diagnosed with a Triple Langmuir probe (TLP) for spatial mapping of the stream in terms of plasma density and temperature. A contour plot for density and temperature shows a distinct form of a highly dense island of plasma with varied plasma temperatures. The formation of such highly dense islands can be correlated with the formation of distinct plasma structures, as observed in astrophysical plasmas and fusion plasma. The results of TLP were supported by the intensity variation derived from signals of a photodetector system. The plasma stream imaged with high‐speed video camera also showed the density fluctuation inside the plasma stream. The estimated maximum density and temperature were ∼7.2 × 1020 m−3 and ∼28 eV, respectively.
Nitrogen addition alleviates the adverse effects of drought on plant productivity in a temperate steppe
Authors: Luo Yonghong , Du Lan , Zhang Jiatao , Ren Haiyan , Shen Yan , Zhang Jinbao , Li Na , Tian Ru , Wang Shan , Liu Heyong , Xu Zhuwen 
Published: April 2024

AbstractDrought and nitrogen enrichment could profoundly affect the productivity of semiarid ecosystems. However, how ecosystem productivity will respond to different drought scenarios, especially with a concurrent increase in nitrogen availability, is still poorly understood. Using data from a 4‐year field experiment conducted in a semiarid temperate steppe, we explored the responses of aboveground net primary productivity (ANPP) to different drought scenarios and nitrogen addition, and the underlying mechanisms linking soil properties, plant species richness, functional diversity (community‐weighted means of plant traits, functional dispersion) and phylogenetic diversity (net relatedness index) to ANPP. Our results showed that completely excluding precipitation in June (1‐month intense drought) and reducing half the precipitation amount from June to August (season‐long chronic drought) both significantly reduced ANPP, with the latter having a more negative impact on ANPP. However, reducing half of the precipitation frequency from June to August (precipitation redistribution) had no significant effect on ANPP. Nitrogen addition increased ANPP irrespective of drought scenarios. ANPP was primarily determined by soil moisture and nitrogen availability by regulating the community‐weighted means of plant height, rather than other aspects of plant diversity. Our findings suggest that precipitation amount is more important than precipitation redistribution in influencing the productivity of temperate steppe, and nitrogen supply could alleviate the adverse impacts of drought on grassland productivity. Our study advances the mechanistic understanding of how the temperate grassland responds to drought stress, and implies that management strategies to protect tall species in the community would be beneficial for maintaining the productivity and carbon sequestration of grassland ecosystems under climate drought.