bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation study of single-anastomosis duodenal-ileal bypass with sleeve gastrectomy in the treatment of Chinese obese patients based on efficacy and nutrition
Authors: Hu Lifu , Wang Lun , Li Shixing , Liu Yang , Zhang Zheng , Xiao Minghao , Zhang Zhenhua , Wei Zhiqiang , Cui Liang , Jiang Tao 
Published: March 2024

AbstractTo evaluate the efficacy and nutrition of single-anastomosis duodenal-ileal bypass with sleeve gastrectomy (SADI-S) in Chinese obese patients in the first postoperative year. Clinical data of 66 obese patients who underwent SADI-S surgery at China-Japan Union Hospital of Jilin University from November 2018 to May 2022 were retrospectively collected. The weight, body mass index (BMI), percentage of excess weight loss (%EWL), and percentage of total weight loss (%TWL) were recorded at 3, 6, and 12 months after surgery. Moreover, metabolic disease remission and nutrient deficiencies were assessed at 1 year postoperatively. Overall, 66 patients (38 males and 28 females) were recruited, with a mean age of 35 (18–61) years and an average preoperative BMI of 42.94 kg/m2. Before surgery, 38 patients had type 2 diabetes mellitus (T2DM), 46 patients had hyperuricemia (HUA), 45 patients had hypertension (HTN), 35 patients had hyperlipidemia, 12 patients had hypercholesterolemia, 12 patients had hyper-low-density lipoproteinemia, and 14 patients had gastroesophageal reflux disease symptoms (GERD). All patients had undergone a DaVinci robotic or laparoscopic SADI-S surgery, and none converted to laparotomy or died. Four patients developed postoperative complications and were cured and discharged after conservative treatment or surgical treatment. At 3, 6 and 12 months, the average %EWL was 62.07 ± 26.56, 85.93 ± 27.92, and 106.65 ± 29.65%, %TWL was 22.67 ± 4.94, 32.10 ± 5.18, and 40.56 ± 7.89%, respectively. Fasting blood glucose (FBG), glycated hemoglobin (HbA1c), uric acid (UA), triglycerides (TG), blood pressure (BP), and other indexes were significantly lower after one year post-surgery compared with the preoperative period (P < 0.05). The remission rates of T2DM, HUA, HTN, hypertriglyceridemia, hypercholesterolemia, and hyper-low-density lipoproteinemia 1 year after surgery were 100, 65.2, 62.2, 94.3, 100, and100%, respectively. One year after surgery, the remission rate of GERD was 71.4% (10/14), the rate of new occurrence of GERD was 12.1% (8/66), and the overall incidence rate was 18.2% (12/66). Except for vitamin B12(vit B12), the other nutrient indexes were significantly decreased after 1 year of surgery relative to levels before surgery (P < 0.05). The deficiency rates for vitamin A (vit A), vitamin E (vit E), zinc ion (Zn), and folic acid (FA) were higher (45.5, 25.8, 24.2, and 16.7%, respectively); however, there were no related clinical symptoms. SADI-S had significant effects on weight loss and metabolic disease remission. The main nutrient deficiencies after SADI-S were vit A, vit E, Zn, and FA deficiencies. The long-term efficacy and safety of SADI-S warrant further follow-up.
Systemic immune-inflammation index as a prognostic marker in HER2-positive breast cancer patients undergoing trastuzumab therapy
Authors: Pang Jian , Ding Nianhua , Yin Nana , Xiao Zhi 
Published: March 2024

AbstractThe prognostic value of SII (Systemic Immune-Inflammation Index) in HER-2-positive breast cancer (BC) patients, regardless of whether they receive trastuzumab treatment, and its potential value to distinguish patients who may benefit from trastuzumab therapy, warrant further investigation. Clinical data was collected from 797 HER-2-positive BC patients between July 2013 and March 2018. Baseline data differences were adjusted with propensity score matching. Univariate and multivariate analyses explored the correlation between clinical pathological factors, SII, and DFS. Four groups were established. Based on the baseline SII values of the participants, patients who did not receive trastuzumab treatment were divided into Group 1 (Low-SII) and Group 2 (High-SII), where SII had no predictive value for prognosis between groups. Participants who received trastuzumab treatment were also divided into two groups: the Low-SII group (Group 3) and the High-SII group (Group 4). The 5-year DFS was significantly higher in Group 3 than in Group 4 (91.76% vs. 82.76%, P = 0.017). Furthermore, multivariate analysis demonstrated a significant association between high SII and shorter DFS (HR = 3.430, 95% CI = 1.830–6.420, P < 0.001). In HER-2-positive BC patients treated with trastuzumab, those with lower SII showed a longer DFS, suggesting that SII may help in identifying patients who benefit from trastuzumab therapy.
Psychometric evaluation of the Chinese version of the Multidimensional Competitive Orientation Inventory
Authors: Wang Yuqian , Orosz Gabor , Chen Xi , Miao Chengguo , Li Yansong 
Published: March 2024

AbstractThis study examined the psychometric properties of the Chinese version of the Multidimensional Competitive Orientation Inventory (Ch-MCOI) in adults from Mainland China. A total of 1121 participants (50.6% male; M = 28.86, SD = 8.70) were recruited for this study. All participants completed the Chinese versions of the MCOI, the Connor-Davidson Resilience Scale (CD-RISC), the Warwick-Edinburgh Mental Well-being Scale (WEMWBS), the Almost Perfect Scale-Revised (APS), the Frost Multidimensional Perfectionism Scale (MPS-f), and the Competition Attitude Scale (Ch-CAS). A subsample of 239 participants (50.6% male; M = 32.04, SD = 8.13) completed the Ch-MCOI again after a two-week interval to assess test–retest reliability. Exploratory Structural Equation Modeling (ESEM) yielded a four-factor structure (hyper-competitive orientation, self-developmental competitive orientation, anxiety-driven competition avoidance, and lack of interest toward competition), which was further validated by confirmatory factor analyses with a satisfactory fit. Furthermore, test–retest reliability, internal consistency, and convergent and concurrent validity were also acceptable. Our findings suggest that the Ch-MCOI could be a reliable and valid instrument for assessing the adaptive and maladaptive facets of competitive orientations in the Chinese-speaking population.
Association between previous surgical termination of pregnancy and pregnancy outcomes in frozen-thawed embryo transfer cycles of IVF/ICSI: a retrospective cohort study
Authors: Zhang Shuai , Tang Hanhan , Zhou Minglian 
Published: March 2024

AbstractThis study aimed to evaluate the effect of previous surgical termination of pregnancy (STP) on pregnancy outcomes in women undergoing FET cycles of IVF/ICSI. Retrospective cohort study. Reproductive Center of Maternal and Child Health Care Hospital in Lianyungang city. Data were selected from all IVF/ICSI FET cycles performed between January 2014 and December 2020. A total of 761 cycles met the criteria were included in this study. The primary outcome measures were clinical pregnancy and live birth rates. Secondary outcome measures were biochemical pregnancy rate, spontaneous abortion rate, and preterm birth rate. After adjustments for a series of potential confounding factors, the previous STP was an influential factor in reducing FET cycle clinical pregnancy rate compared with women who had not previously undergone STP (OR = 0.614, 95% CI 0.413–0.911, P = 0.016). The effect of the previous STP on the live birth rate was not statistically significant. (OR = 0.745, 95% CI 0.495–1.122, P = 0.159). Also, an increase in the number of previous STPs relative to only 1-time abortion was an independent risk factor in reducing clinical pregnancy rate and live birth rate (OR = 0.399,95% CI 0.162–0.982, p = 0.046; OR = 0.32,95% CI 0.119–0.857, p = 0.023). Previous STP was an independent factor contributing to the decline in FET cycle clinical pregnancy rates.
Trigonelline is an NAD+ precursor that improves muscle function during ageing and is reduced in human sarcopenia
Authors: Membrez Mathieu , Migliavacca Eugenia , Christen Stefan , Yaku Keisuke , Trieu Jennifer , Lee Alaina K. , Morandini Francesco , Giner Maria Pilar , Stiner Jade , Makarov Mikhail V. , Garratt Emma S. , Vasiloglou Maria F. , Chanvillard Lucie , Dalbram Emilie , Ehrlich Amy M. , Sanchez-Garcia José Luis , Canto Carles , Karagounis Leonidas G. , Treebak Jonas T. , Migaud Marie E. , Heshmat Ramin , Razi Farideh , Karnani Neerja , Ostovar Afshin , Farzadfar Farshad , Tay Stacey K. H. , Sanders Matthew J. , Lillycrop Karen A. , Godfrey Keith M. , Nakagawa Takashi , Moco Sofia , Koopman René , Lynch Gordon S. , Sorrentino Vincenzo , Feige Jerome N. 
Published: March 2024

AbstractMitochondrial dysfunction and low nicotinamide adenine dinucleotide (NAD+) levels are hallmarks of skeletal muscle ageing and sarcopenia1–3, but it is unclear whether these defects result from local changes or can be mediated by systemic or dietary cues. Here we report a functional link between circulating levels of the natural alkaloid trigonelline, which is structurally related to nicotinic acid4, NAD+ levels and muscle health in multiple species. In humans, serum trigonelline levels are reduced with sarcopenia and correlate positively with muscle strength and mitochondrial oxidative phosphorylation in skeletal muscle. Using naturally occurring and isotopically labelled trigonelline, we demonstrate that trigonelline incorporates into the NAD+ pool and increases NAD+ levels in Caenorhabditis elegans, mice and primary myotubes from healthy individuals and individuals with sarcopenia. Mechanistically, trigonelline does not activate GPR109A but is metabolized via the nicotinate phosphoribosyltransferase/Preiss–Handler pathway5,6 across models. In C. elegans, trigonelline improves mitochondrial respiration and biogenesis, reduces age-related muscle wasting and increases lifespan and mobility through an NAD+-dependent mechanism requiring sirtuin. Dietary trigonelline supplementation in male mice enhances muscle strength and prevents fatigue during ageing. Collectively, we identify nutritional supplementation of trigonelline as an NAD+-boosting strategy with therapeutic potential for age-associated muscle decline.
IFNα induces CCR5 in CD4+ T cells of HIV patients causing pathogenic elevation
Authors: Le Buanec Hélène , Schiavon Valérie , Merandet Marine , How-Kit Alexandre , Song Hongshuo , Bergerat David , Fombellida-Lopez Céline , Bensussan Armand , Bouaziz Jean-David , Burny Arsène , Darcis Gilles , Sajadi Mohammad M. , Kottilil Shyamasundaran , Zagury Daniel , Gallo Robert C. 
Published: March 2024

Abstract
Background
Among people living with HIV, elite controllers (ECs) maintain an undetectable viral load, even without receiving anti-HIV therapy. In non-EC patients, this therapy leads to marked improvement, including in immune parameters, but unlike ECs, non-EC patients still require ongoing treatment and experience co-morbidities. In-depth, comprehensive immune analyses comparing EC and treated non-EC patients may reveal subtle, consistent differences. This comparison could clarify whether elevated circulating interferon-alpha (IFNα) promotes widespread immune cell alterations and persists post-therapy, furthering understanding of why non-EC patients continue to need treatment.

Methods
Levels of IFNα in HIV-infected EC and treated non-EC patients were compared, along with blood immune cell subset distribution and phenotype, and functional capacities in some cases. In addition, we assessed mechanisms potentially associated with IFNα overload.

Results
Treatment of non-EC patients results in restoration of IFNα control, followed by marked improvement in distribution numbers, phenotypic profiles of blood immune cells, and functional capacity. These changes still do not lead to EC status, however, and IFNα can induce these changes in normal immune cell counterparts in vitro. Hypothesizing that persistent alterations could arise from inalterable effects of IFNα at infection onset, we verified an IFNα-related mechanism. The protein induces the HIV coreceptor CCR5, boosting HIV infection and reducing the effects of anti-HIV therapies. EC patients may avoid elevated IFNα following on infection with a lower inoculum of HIV or because of some unidentified genetic factor.

Conclusions
Early control of IFNα is essential for better prognosis of HIV-infected patients.
Early elevated IFNα is a key mediator of HIV pathogenesis
Authors: Buanec Hélène Le , Schiavon Valérie , Merandet Marine , How-Kit Alexandre , Bergerat David , Fombellida-Lopez Céline , Bensussan Armand , Bouaziz Jean-David , Burny Arsène , Darcis Gilles , Song Hongshuo , Sajadi Mohammad M. , Kottilil Shyamasundaran , Gallo Robert C. , Zagury Daniel 
Published: March 2024

Abstract
Background
A complete understanding of the different steps of HIV replication and an effective drug combination have led to modern antiretroviral regimens that block HIV replication for decades, but these therapies are not curative and must be taken for life. “Elite controllers” (ECs) is a term for the 0.5% of HIV-infected persons requiring no antiretroviral therapy, whose status may point the way toward a functional HIV cure. Defining the mechanisms of this control may be key to understanding how to replicate this functional cure in others.

Methods
In ECs and untreated non-EC patients, we compared IFNα serum concentration, distribution of immune cell subsets, and frequency of cell markers associated with immune dysfunction. We also investigated the effect of an elevated dose of IFNα on distinct subsets within dendritic cells, natural killer cells, and CD4+ and CD8 + T cells.

Results
Serum IFNα was undetectable in ECs, but all immune cell subsets from untreated non-EC patients were structurally and functionally impaired. We also show that the altered phenotype and function of these cell subsets in non-EC patients can be recapitulated when cells are stimulated in vitro with high-dose IFNα.

Conclusions
Elevated IFNα is a key mediator of HIV pathogenesis.
Fine-tuning FAM161A gene augmentation therapy to restore retinal function
Authors: Arsenijevic Yvan , Chang Ning , Mercey Olivier , El Fersioui Younes , Koskiniemi-Kuendig Hanna , Joubert Caroline , Bemelmans Alexis-Pierre , Rivolta Carlo , Banin Eyal , Sharon Dror , Guichard Paul , Hamel Virginie , Kostic Corinne 
Published: March 2024

AbstractFor 15 years, gene therapy has been viewed as a beacon of hope for inherited retinal diseases. Many preclinical investigations have centered around vectors with maximal gene expression capabilities, yet despite efficient gene transfer, minimal physiological improvements have been observed in various ciliopathies. Retinitis pigmentosa-type 28 (RP28) is the consequence of bi-allelic null mutations in the FAM161A, an essential protein for the structure of the photoreceptor connecting cilium (CC). In its absence, cilia become disorganized, leading to outer segment collapses and vision impairment. Within the human retina, FAM161A has two isoforms: the long one with exon 4, and the short one without it. To restore CC in Fam161a-deficient mice shortly after the onset of cilium disorganization, we compared AAV vectors with varying promoter activities, doses, and human isoforms. While all vectors improved cell survival, only the combination of both isoforms using the weak FCBR1-F0.4 promoter enabled precise FAM161A expression in the CC and enhanced retinal function. Our investigation into FAM161A gene replacement for RP28 emphasizes the importance of precise therapeutic gene regulation, appropriate vector dosing, and delivery of both isoforms. This precision is pivotal for secure gene therapy involving structural proteins like FAM161A.
Clinical Focus: The Development and Description of a Palette of Transmasculine Voices
Authors: Dolquist Devin V. , Munson Benjamin 
Published: March 2024

Purpose:
The study of gender and speech has historically excluded studies of transmasculine individuals. Consequently, generalizations about speech and gender are based on cisgender individuals. This lack of representation hinders clinical training and clinical service delivery, particularly by speech-language pathologists providing gender-affirming communication services. This letter describes a new corpus of the speech of American English–speaking transmasculine men, transmasculine nonbinary people, and cisgender men that is open and available to clinicians and researchers.

Method:
Twenty masculine-presenting native English speakers from the Upper Midwestern United States (including cisgender men, transmasculine men, and transmasculine nonbinary people) were recorded, producing three sets of speech materials: Consensus Auditory–Perceptual Evaluation of Voice sentences, the Rainbow Passage, and a novel set of sentences developed for this project. Acoustic measures vowels (overall formant frequency scaling, vowel–space dispersion, fundamental frequency, breathiness), consonants (voice onset time of word-initial voiceless stops, spectral moments of word-initial /s/), and the entire sentence (rate of speech) that were made.

Results:
The acoustic measures reveal a wide range for all dependent measures and low correlations among the measures. Results show that many of the voices depart considerably from the norms for men's speech in published studies.

Conclusion:
This new corpus can be used to illustrate different ways of sounding masculine by speech-language pathologists performing gender-affirming communication services and by higher education teachers as examples of diverse ways of sounding masculine.
Dynamic modelling and a dual vector modulated improved model predictive control with auto tuning feature of active front‐end converters for distributed energy resources
Authors: Debnath Rajdip , Gupta Gauri Shanker , Kumar Deepak , Tripathi Prabhat R. , El‐Saadany Ehab F. , Fendzi Mbasso Wulfran , Kamel Salah 
Published: March 2024

AbstractThe operational performance of grid‐connected active front‐end converters (AFEs) faces challenges arising from the intricate interplay among phase‐locked loop (PLL) non‐linearities, grid impedance, and conventional control strategies, resulting in compromised stability. This study introduces a refined approach to dynamic model predictive control (MPC) by integrating recursive least squares (RLS) for the precise estimation of physical model parameters, thereby addressing stability concerns. Unlike conventional methodologies, the proposed enhanced RLS‐based MPC approach, equipped with an auto‐tuning feature, allows for the design of controllers without a prerequisite understanding of exact external dynamics. Notably, this technique exhibits exceptional disturbance rejection capabilities. The evaluation of the cost function at each sampling interval facilitates the determination of optimal switching states based on predicted variables. Gate pulses for the switches of the AFEs are generated accordingly. Employing a simulation platform, the proposed control structure's performance across varied conditions is comprehensively assessed, encompassing alterations in grid impedance and system non‐linearities. The method adeptly integrates inherent non‐linearities within the system, showcasing exceptional robustness in diverse dynamic scenarios. To further substantiate the efficacy of the proposed control system over conventional approaches, simulation results are validated using a laboratory hardware platform equipped with Typhoon HIL and dSPACE real‐time emulators, providing tangible evidence of the proposed control system's effectiveness in real‐world hardware setups. The multifaceted approach, encompassing precise parameter estimation, predictive control, auto‐tuning, disturbance rejection, robust design, and real‐time evaluation, collectively establishes a resilient foundation for enhancing and maintaining the overall stability of the system across diverse operating scenarios.
Time evolution of the galactic B - ρ relation: The impact of the magnetic field morphology
Authors: Konstantinou A. , Ntormousi E. , Tassis K. , Pallottini A. 
Published: March 2024

Context. One of the indicators most frequently used to characterize the magnetic field’s influence on star formation is the relation between the magnetic field strength and the gas density (the B − p relation), usually expressed as a power law of the form B ∝ ρκ. The value of κ is an indication of the dynamical importance of the magnetic field during gas compression.
Aims. In this work, we investigate the role of the global magnetic field morphology on a galaxy’s B − ρ relation, as well as the evolution of the relation over time.
Methods. We developed magnetohydrodynamic simulations of Milky Way-like galaxies that include gravity, star formation, and supernova feedback. The models take into account nonequilibrium chemistry up to H2 formation, which is used to fuel star formation. We considered two different initial magnetic field morphologies: one completely ordered (toroidal) and the other completely random. Using these models, we studied the dynamical importance of the magnetic field through the plasma ß and the B − ρ relation.
Results. For both magnetic morphologies, low-density regions are thermally supported, while high-density regions are magnetically dominated. Equipartition is reached earlier and at lower densities in the toroidal model. However, the B − ρ relation varies, even within the same galaxy, as it consistently includes two different branches for a given density, with κ ranging from about 0.2 to 0.8. The mean value of κ for each model also varies significantly over time, which supersedes the differences between the two models.
Conclusions. While our findings suggest that the magnetic field morphology does influence the galactic B − ρ relation, its impact is transient in nature since time-averaged differences between the models fall within the large temporal scatter. The context and time-dependent nature of the B − ρ relation underscore the need for comprehensive research and observations to understand the intricate role of magnetic fields in star formation processes across diverse galactic environments.