bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anti-sulfatide antibody-related Guillain–Barré syndrome presenting with overlapping syndromes or severe pyramidal tract damage: a case report and literature review
Authors: Ji Xiaotian , Zhu Jiaqian , Li Lujiang , Yang Xiaodan , Zhou Shaolong , Cao Liming 
Published: April 2024

IntroductionAnti-sulfatide antibodies are key biomarkers for the diagnosis of Guillain–Barré syndrome (GBS). However, case reports on anti-sulfatide antibody-related GBS are rare, particularly for atypical cases.Case description, case 1A 63 years-old man presented with limb numbness and diplopia persisting for 2 weeks, with marked deterioration over the previous 4 days. His medical history included cerebral infarction, diabetes, and coronary atherosclerotic cardiomyopathy. Physical examination revealed limited movement in his left eye and diminished sensation in his extremities. Initial treatments included antiplatelet agents, cholesterol-lowering drugs, hypoglycemic agents, and medications to improve cerebral circulation. Despite this, his condition worsened, resulting in bilateral facial paralysis, delirium, ataxia, and decreased lower limb muscle strength. Treatment with intravenous high-dose immunoglobulin and dexamethasone resulted in gradual improvement. A 1 month follow-up revealed significant neurological sequelae.Case description, case 2A 53 years-old woman was admitted for adenomyosis and subsequently experienced sudden limb weakness, numbness, and pain that progressively worsened, presenting with diminished sensation and muscle strength in all limbs. High-dose intravenous immunoglobulin, vitamin B1, and mecobalamin were administered. At the 1 month follow-up, the patient still experienced limb numbness and difficulty walking. In both patients, albuminocytologic dissociation was found on cerebrospinal fluid (CSF) analysis, positive anti-sulfatide antibodies were detected in the CSF, and electromyography indicated peripheral nerve damage.ConclusionAnti-sulfatide antibody-related GBS can present with Miller–Fisher syndrome, brainstem encephalitis, or a combination of the two, along with severe pyramidal tract damage and residual neurological sequelae, thereby expanding the clinical profile of this GBS subtype. Anti-sulfatide antibodies are a crucial diagnostic biomarker. Further exploration of the pathophysiological mechanisms is necessary for precise treatment and improved prognosis.
Self supervised learning based emotion recognition using physiological signals
Authors: Zhang Min , Cui YanLi 
Published: April 2024

IntroductionThe significant role of emotional recognition in the field of human-machine interaction has garnered the attention of many researchers. Emotion recognition based on physiological signals can objectively reflect the most authentic emotional states of humans. However, existing labeled Electroencephalogram (EEG) datasets are often of small scale.MethodsIn practical scenarios, a large number of unlabeled EEG signals are easier to obtain. Therefore, this paper adopts self-supervised learning methods to study emotion recognition based on EEG. Specifically, experiments employ three pre-defined tasks to define pseudo-labels and extract features from the inherent structure of the data.Results and discussionExperimental results indicate that self-supervised learning methods have the capability to learn effective feature representations for downstream tasks without any manual labels.
Comparison of chemotherapy and chidamide combined with chemotherapy in patients with untreated angioimmunoblastic T-cell lymphoma
Authors: Gu Simeng , Wang Xin , Zhou Jingqiu , Du Shanshan , Niu Ting 
Published: April 2024

BackgroundAngioimmunoblastic T-cell lymphoma (AITL) is characterized by high recurrence rates and poor prognosis, and effective first-line treatment is lacking. Recently, histone deacetylase inhibitors (HDACi), such as chidamide, have been found to induce durable remissions in AITL patients.MethodsPatients with untreated AITL from March 2015 to March 2023 were retrospectively collected and divided into chemotherapy (ChT) group and chidamide combined with chemotherapy (C-ChT) group based on the first-line treatment received. The comparison of efficacy and safety between the two groups was conducted.Results86 patients with newly diagnosed AITL were enrolled, in which 35 patients were in the ChT group and 51 in the C-ChT group. The objective response rate (ORR) of C-ChT group was significantly higher than that of ChT group (84.3% vs. 60%, P= 0.011), and had superior progression-free survival (PFS) (27 months vs. 12 months, P= 0.025). However, no significant difference in overall survival (OS) was observed between the two groups (P= 0.225). In addition, the responding patients who received autologous stem cell transplantation (ASCT) had superior PFS compared to those who did not (P= 0.015).ConclusionsCompared with ChT regimen, C-ChT regimen was well tolerated and had superior ORR and PFS in patients with untreated AITL. ASCT may contribute to longer PFS in remission patients.
Reliability of renal point-of-care ultrasound (POCUS) performed by pediatric postgraduates to diagnose hydronephrosis in infants
Authors: Cheon Eun Jung , Yoon Jung Min 
Published: April 2024

PurposePoint-of-care ultrasound (POCUS) has gained prominence in a variety of medical specialties due to advances in ultrasound technology. POCUS has not been fully integrated into pediatric residency training programs despite its widespread use and proven benefits. At our institution, renal POCUS is performed by pediatric residents for the evaluation of hydronephrosis, which is the main pathology for which ultrasound is used in the clinical practice of pediatric nephrology. This study was conducted to evaluate the quality of renal POCUS performed by pediatric residents in infants.MethodsFour pediatric residents, comprising two first-year and two second-year residents at Konyang University Hospital, participated in the study conducted from May 2021 to May 2022. All participants had completed our Point-of-Care Ultrasound (POCUS) training program. The study focused on infants admitted to the pediatric inpatient unit, identified by attending physicians as requiring renal ultrasound. All infants underwent their initial kidney ultrasound examination. Temporal alignment between renal Point-of-Care Ultrasound (POCUS) performed by pediatric residents and conventional ultrasound (USG) conducted by radiologists was asynchronous. Pediatric residents conducted POCUS sessions during scheduled radiologist appointments throughout the day, occurring either before or after the radiologist's examination. There was no mutual awareness of each other's results. Inter-observer agreement between radiologists and pediatric residents was compared for the presence or absence of hydronephrosis and its grade, which are primary considerations in pediatric renal ultrasound.ResultsOur study found that 53 infants (68.8%) were diagnosed with hydronephrosis using point-of-care ultrasound (POCUS), compared to 48 infants (62.3%) diagnosed with conventional ultrasound (USG). Among the POCUS examinations conducted by pediatric residents, hydronephrosis of SFU grades 1, 2, 3, and 4 were observed in 56.6%, 35.8%, 7.5%, and 0%, respectively. Inter-observer reliability between POCUS and conventional USG showed good agreement, with Cohen's kappa coefficients exceeding 0.8 for sensitivity and 0.6 for grading.ConclusionsRenal POCUS performed well in diagnosing and grading hydronephrosis in infants when performed by pediatric residents who had completed a two-phase training program.
Logistic regression analysis of risk factors for pediatric burns: a case–control study in underdeveloped minority areas in China
Authors: Lin Ziren , Iyappan Petchi , Huang Zhiqun , Sooranna Suren Rao , Wu Yongfang , Lan Liuting , Huang Cheng , Liang Feiteng , Zhao Daji , Huang Dingjin 
Published: April 2024

BackgroundPediatric burns are common, especially in underdeveloped countries, and these can physically affect the children involved and have an impact on their mental health. The aim of the present study was to assess the effect of pediatric burns in underdeveloped minority areas of China.MethodsCase information from 192 children was collected from outpatient and inpatient clinics using a survey questionnaire. These included 90 pediatric burn cases and 102 controls who were children without burns. A stepwise logistic regression analysis was used to determine the risk factors for pediatric burns in order to establish a model. The goodness-of-fit for the model was assessed using the Hosmer and Lemeshow test as well as receiver operating characteristic and internal calibration curves. A nomogram was then used to analyze the contribution of each influencing factor to the pediatric burns model.ResultsSeven variables, including gender, age, ethnic minority, the household register, mother’s employment status, mother’s education and number of children, were analyzed for both groups of children. Of these, age, ethnic minority, mother’s employment status and number of children in a household were found to be related to the occurrence of pediatric burns using univariate logistic regression analysis (p &lt; 0.05). After a collinearity diagnosis, a multivariate logistic regression analysis of variables with tolerances of &gt;0.2 and variance inflation factor &lt;5 showed that age was a protective factor for pediatric burns [odds ratio (OR) = 0.725; 95% confidence interval (CI): 0.665–0.801]. Compared with single-child parents, those with two children were at greater risk of pediatric burns (OR = 0.389; 95% CI: 0.158–0.959). The ethnic minority of the child and the mother’s employment status were also risk factors (OR = 6.793; 95% CI: 2.203–20.946 and OR = 2.266; 95% CI: 1.025–5.012, respectively). Evaluation of the model used was found to be stable. A nomogram showed that the contribution in the children burns model was age &gt; mother’s employment status &gt; number of children &gt; ethnic minority.ConclusionsThis study showed that there are several risk factors strongly correlated to pediatric burns, including age, ethnic minority, the number of children in a household and mother’s employment status. Government officials should direct their preventive approach to tackling the problem of pediatric burns by promoting awareness of these findings.
Identification of active compounds in Vernonia anthelmintica (L.) willd by targeted metabolome MRM and kaempferol promotes HaCaT cell proliferation and reduces oxidative stress
Authors: Hu Wen , Wang Hongjuan , Li Kaixiao , Lei Zixian , Xiang Fang , Li Jun , Kang Xiaojing 
Published: April 2024

Introduction:Vernonia anthelmintica (L.) Willd. is a traditional treatment for vitiligo in Xinjiang. However, its therapeutic mechanism remains unclear owing to its complex composition and limited research on its chemical profile.Methods: We employed a targeted metabolome approach, combining selective reaction monitoring/multiple response monitoring (SRM/MRM) with high-performance liquid chromatography and MRM mass spectrometry to quantitatively analyze the flavonoid constituents of Vernonia anthelmintica. We also used network pharmacology and molecular docking to identify potential vitiligo-linked compounds and targets of V. anthelmintica seeds. Additionally, we assessed HaCaT cell proliferation by AAPH-induced, alongside changes in SOD activity and MDA content, following treatment with V. anthelmintica components. Finally, flow cytometry was used to detect apoptosis and ROS levels.Results and Discussion: We identified 36 flavonoid compounds in V. anthelmintica seeds, with 14 compounds exhibiting druggability. AKT1, VEGFA, ESR1, PTGS2, and IL2 have been identified as key therapeutic target genes, with PI3K/AKT signaling being an important pathway. Notably, kaempferol, one of the identified compounds, exhibited high expression in network pharmacology analysis. Kaempferol exhibited a strong binding affinity to important targets. Further, kaempferol enhanced HaCaT cell viability, inhibited apoptosis, reduced MDA levels, suppressed ROS activity, and upregulated SOD activity, increase the expression of cellular antioxidant genes, including HO-1, GCLC, GCLM, Nrf2, NQO1 and Keap1, providing significant protection against oxidative stress damage in vitro. Here, we present the first comprehensive study integrating SRM/MRM approaches and network analysis to identify active flavonoid compounds within V. anthelmintica (L.) Willd. Moreover, we revealed that its active ingredient, kaempferol, offers protection against AAPH-induced damage in keratinocytes, highlighting its potential as a clinical resource.
Temporal characteristics and associated factors of discontinuation and outcomes after percutaneous coronary intervention
Authors: Xu Haiyan , Zheng Wanxiang , Tan Jiangqin , Li Min 
Published: April 2024

Background: Medication adherence in patients after percutaneous coronary intervention (PCI) is suboptimal, and discontinuation is common. Information on the temporal characteristics and associated factors of discontinuation and outcomes after PCI is insufficient to improve medication adherence interventions.Methods: We conducted a single-center retrospective study of post-PCI patients by telephone survey and medical record extraction. Temporal characteristics and associated factors of discontinuation and outcomes were examined by survival curve analysis, Cox regression, or time-dependent Cox regression.Results: Discontinuation and major adverse cardiovascular events (MACE) after PCI had similar temporal characteristics, with the highest incidence in the first year, followed by a decline. Temporary discontinuation was associated with pre-PCI medication nonadherence (HR 1.63; 95% CI: 1.09–2.43), lack of medication necessity (HR 2.33; 95% CI: 1.44–3.78), economic difficulties (HR 2.09; 95% CI: 1.26–3.47), routine disruption (HR 2.09; 95% CI: 1.10–3.99), and emotional distress (HR 2.76; 95% CI: 1.50–5.09). Permanent discontinuation was associated with residence in rural areas (HR 4.18; 95% CI: 1.84–9.46) or small to medium-sized cities (HR 4.21; 95% CI: 1.82–9.73), lack of medication necessity (HR 10.60; 95% CI: 6.45–17.41), and side effects (HR 3.30; 95% CI: 1.94–5.62). The MACE after PCI was associated with pre-PCI hypertension (HR 1.42; 95% CI: 1.04–1.96), two coronary stents (HR 1.42; 95% CI: 1.01–1.99) or three coronary stents (HR 1.66; 95% CI: 1.11–2.49) compared to one coronary stent up to this PCI, and temporary discontinuation (≤60 months HR 2.18; 95% CI: 1.47–3.25; &gt;60 months HR 8.82; 95% CI: 3.65–21.28).Conclusion: Discontinuation and MACE after PCI have similar temporal characteristics, temporary discontinuation and permanent discontinuation have different associated factors, and the former is associated with MACE. These findings may provide guidance for medication adherence interventions.
The path of ideological and political education in fulfilling the function of psychological nurturing
Authors: Xue Feng , Wei Naixue , Wu Xinxiong 
Published: April 2024

IntroductionThe risk of college students facing psychological problems, such as stress, anxiety, and depression, has increased, which may have a negative impact ontheir academic performance and overall well-being, especially after the outbreakof the pandemic.MethodsThis paper summarizes the potential psychological issues thatuniversity students may face and the corresponding coping measures. Basedon this, a theoretical model of ideological and political education to enhancepsychological education was established.ResultsThere was a total of 446 participantsin the study, with a mean age of 21.4 years and 44.6 per cent male. With 406 valid survey responses, the theoretical model was examined using the structuralequation modeling method. The results showed that education and teaching, practical activities, counseling services, prevention and intervention, and multilevelplatforms are effective measures to protect the psychological health ofuniversity students.DiscussionBased on the insights gained from this study, policies canbe implemented to help university students improve their mental health andinspire higher education institutions to prioritize psychological education.
A two-item screening of maternal or infant perceived life threat during childbirth prospectively associated with childbirth-related posttraumatic stress symptoms up to six months postpartum: two observational longitudinal studies
Authors: Gilbert Leah , Sandoz Vania , Deforges Camille , Horsch Antje 
Published: April 2024

ObjectiveThis study investigated prospective relationships between the perception of threat to one’s own life or to that of one’s infant during childbirth and maternal childbirth-related posttraumatic stress symptoms (CB-PTSS) and probable childbirth-related posttraumatic stress disorder (CB-PTSD) in a community and a community and an emergency cesarean section (ECS) sample.MethodsStudy samples included 72 mothers from a community sample and 75 mothers after emergency cesarean section. Perceived maternal and infant life threat were assessed at ≤1 week postpartum. Maternal CB-PTSS and probable CB-PTSD were assessed with validated questionnaires up to 6 months postpartum. Covariates were extracted from hospital records. Secondary data analysis with logistic and linear regressions was performed.ResultsGlobally, mothers were significantly more likely to perceive their infant’s life to be threatened, rather than their own. Both types of perceived threat were prospectively but differentially associated with maternal CB-PTSS and probable CB-PTSD at 4-6 weeks and 6 months postpartum. Statistical significance was set at p&lt;0.05.ConclusionThe type of perceived threat differently influences maternal CB-PTSS and probable CB-PTSD up to 6 months postpartum. These results may be the basis for the development of a short screening instrument after traumatic childbirth in clinical settings. Future studies need to assess the psychometric properties and acceptability of such a brief screening tool.
Achieving sustainable medical tourism: unpacking privacy concerns through a tripartite game theoretic lens
Authors: Wang Ran , Geng Songtao 
Published: April 2024

IntroductionMedical tourism has grown significantly, raising critical concerns about the privacy of medical tourists. This study investigates privacy issues in medical tourism from a game theoretic perspective, focusing on how stakeholders’ strategies impact privacy protection.MethodsWe employed an evolutionary game model to explore the interactions between medical institutions, medical tourists, and government departments. The model identifies stable strategies that stakeholders may adopt to protect the privacy of medical tourists.ResultsTwo primary stable strategies were identified, with E6(1,0,1) emerging as the optimal strategy. This strategy involves active protection measures by medical institutions, the decision by tourists to forgo accountability, and strict supervision by government departments. The evolution of the system’s strategy is significantly influenced by the government’s penalty intensity, subsidies, incentives, and the compensatory measures of medical institutions.DiscussionThe findings suggest that medical institutions are quick to make decisions favoring privacy protection, while medical tourists tend to follow learning and conformity. Government strategy remains consistent, with increased subsidies and penalties encouraging medical institutions towards proactive privacy protection strategies. We recommend policies to enhance privacy protection in medical tourism, contributing to the industry’s sustainable growth.
Correlation among job-induced stress, overall well-being, and cardiovascular risk in Italian workers of logistics and distribution
Authors: Fruscione Santo , Malta Ginevra , Verso Maria Gabriella , Calascibetta Anna , Martorana Daniela , Cannizzaro Emanuele 
Published: April 2024

IntroductionWork-related stress is an occupational risk that has been linked to the development of cardiovascular disease (CVD). While previous studies have explored this association in various work contexts, none have focused specifically on logistics and distribution personnel. These workers may be exposed to significant job stress, which potentially increases the risk of CVD.MethodsIn this study, we aimed to examine the relationship between work-related stress and cardiovascular risk in a sample of 413 healthy workers of a logistics and distribution company. To assess work-related stress and cardiovascular risk, we used the organisational well-being questionnaire proposed by the Italian National Anti-Corruption Authority, the Framingham Heart Study General Cardiovascular Disease (CVD) Risk Prediction Score and the WHO General Wellbeing Index (WHO-5).ResultsOur results revealed that individuals with low job support had a significantly higher CVD risk score and lower well-being index than those reporting high job support. Furthermore, workers with high-stress tasks showed higher well-being index scores than those with passive tasks. Approximately 58% of the subjects were classified as low CVD risk (CVD risk &lt;10%), approximately 31% were classified as moderate risk (CVD risk between 10 and 20%) and 11% were considered high risk (CVD risk &gt;20%). The overall median CVD risk for the population was moderate (6.9%), with individual scores ranging from 1 to 58%.DiscussionFurther analyses confirmed the protective effect of work support, also identifying physical inactivity, regular alcohol consumption and low educational level as factors contributing to an increased risk of CVD. Interestingly, factors such as job control and work support demonstrated a positive impact on psychological well-being. These results emphasise the importance of intervention strategies aimed at promoting health in the workplace. By addressing these combined factors, organisations can effectively reduce the risk of CVD and improve the general well-being of their workforce.
Consulting doctors online after offline treatment: investigating the effects of online information on patients' effective use of online follow-up services
Authors: Han Shuhui , Li Lun 
Published: April 2024

IntroductionThe use of online follow-up services (OFUS) is becoming an increasingly important supplement to hospital care. Through OFUS, patients can find their doctors in online health communities (OHCs) and receive remote medical follow-ups after hospital treatment. However, the rate of effective use of OFUS by current patients is still low, and there is an urgent need for research to investigate the online information factors that affect patients' effective use of OFUS.MethodsBased on the elaboration likelihood model (ELM) of persuasion and an analysis of a panel dataset including 3,672 doctors in a leading OHC in China, this study explores how online information from doctors' knowledge contributions and patient feedback influences patients' effective use of OFUS.ResultsThe results show that both doctors' knowledge contributions and patient feedback positively influence patients' effective use of OFUS. Doctors' paid knowledge contributions and patients' paid feedback have stronger persuasive effects than doctors' free knowledge contributions and patients' free feedback, respectively. Moreover, there is a substitutional relationship between doctors' paid and free knowledge contributions and between patients' paid and free feedback in influencing patients' effective use of OFUS.DiscussionThe findings of this study suggest that OHC platforms and healthcare providers should account not only for the persuasive effects of doctors' knowledge contributions and patient feedback but also for influential differences and relationships between the types of doctors' knowledge contributions and patient feedback to better persuade patients to effectively use OFUS.