bluuebunny/crossref_metadata_2025_split huggingface dataset:
$$\Xi (1620)^-$$ production in $$K^- p$$ scattering process
Authors: Guo Quan-Yun , Yue Zi-Li , Chen Dian-Yong 
Published: April 2024

AbstractIn the present work, the production of $$\Xi (1620)^-$$

Ξ

(
1620
)

-

in the $$K^- p$$

K
-

p

scattering process is investigated by using an effective Lagrangian approach, where $$\Xi (1620)^-$$

Ξ

(
1620
)

-

is considered as a $$K^- \Lambda $$

K
-

Λ

molecular state. Our estimations indicate that the cross sections for $$K^-p\rightarrow K^+ \Xi (1620)^-$$

K
-

p
→

K
+

Ξ

(
1620
)

-

are $$(1.48 ^{+ 1.12}_{-0.69}) \, \upmu \textrm{b}$$

(
1
.

48

-
0.69

+
1.12

)

μ
b

at $$P_K=2.8 \ \textrm{GeV}$$

P
K

=
2.8

GeV

, where the uncertainties are resulted from the variation of the model parameter. As for the $$K^-p\rightarrow \pi ^0 \Xi ^- K^+$$

K
-

p
→

π
0

Ξ
-

K
+

process, the cross sections are estimated to be $$(0.61 ^{+0.47}_{-0.29})\, \upmu \textrm{b}$$

(
0
.

61

-
0.29

+
0.47

)

μ
b

at $$P_K =2.87 \ \textrm{GeV}$$

P
K

=
2.87

GeV

, which is consistent with the experimental measurements.
FRACTAL DIMENSIONS FOR THE MIXED (κ,s)-RIEMANN–LIOUVILLE FRACTIONAL INTEGRAL OF BIVARIATE FUNCTIONS
Authors: WANG B. Q. , XIAO W. 
Published: April 2024

The research object of this paper is the mixed [Formula: see text]-Riemann–Liouville fractional integral of bivariate functions on rectangular regions, which is a natural generalization of the fractional integral of univariate functions. This paper first indicates that the mixed integral still maintains the validity of the classical properties, such as boundedness, continuity and bounded variation. Furthermore, we investigate fractal dimensions of bivariate functions under the mixed integral, including the Hausdorff dimension and the Box dimension. The main results indicate that fractal dimensions of the graph of the mixed [Formula: see text]-Riemann–Liouville integral of continuous functions with bounded variation are still two. The Box dimension of the mixed integral of two-dimensional continuous functions has also been calculated. Besides, we prove that the upper bound of the Box dimension of bivariate continuous functions under [Formula: see text] order of the mixed integral is [Formula: see text] where [Formula: see text].
Feature Engineering Versus Deep Learning for Scene Recognition: A Brief Survey
Authors: Susan Seba , Tuteja Maduri 
Published: April 2024

Scene recognition is an important computer vision task that has evolved from the study of the biological visual system. Its applications range from video surveillance, autopilot systems, to robotics. The early works were based on feature engineering that involved the computation and aggregation of global and local image descriptors. Several popular image features such as SIFT, SURF, HOG, ORB, LBP, KAZE, etc. have been proposed and applied to the task with successful results. Features can be either computed from the entire image on a global scale, or extracted from local sub-regions and aggregated across the image. Suitable classifier models are deployed that learn to classify these features. This review paper analyzes several of these handcrafted features that have been applied to the scene recognition task over the past decades, and tracks the transition from the traditional feature engineering to deep learning which forms the current state of the art in computer vision. Deep learning is now deemed to have overtaken feature engineering in several computer vision applications. Deep convolutional neural networks and vision transformers are the current state of the art for object recognition. However, scenes from urban landscapes are bound to contain similar objects posing a challenge to deep learning solutions for scene recognition. In our study, a critical analysis of feature engineering and deep learning methodologies for scene recognition is provided, and results on benchmark scene datasets are presented, concluding with a discussion on challenges and possible solutions that may facilitate more accurate scene recognition.
Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers
Authors: Jiang Jingjing , Jiang Lingyan , Maldonato Benjamin J. , Wang Yingyun , Holderfield Matthew , Aronchik Ida , Winters Ian P. , Salman Zeena , Blaj Cristina , Menard Marie , Brodbeck Jens , Chen Zhe , Wei Xing , Rosen Michael J. , Gindin Yevgeniy , Lee Bianca J. , Evans James W. , Chang Stephanie , Wang Zhican , Seamon Kyle J. , Parsons Dylan , Cregg James , Marquez Abby , Tomlinson Aidan C.A. , Yano Jason K. , Knox John E. , Quintana Elsa , Aguirre Andrew J. , Arbour Kathryn C. , Reed Abby , Gustafson W. Clay , Gill Adrian L. , Koltun Elena S. , Wildes David , Smith Jacqueline A.M. , Wang Zhengping , Singh Mallika 
Published: April 2024

Abstract

RAS-driven cancers comprise up to 30% of human cancers. RMC-6236 is a RAS(ON) multi-selective noncovalent inhibitor of the active, GTP-bound state of both mutant and wild-type variants of canonical RAS isoforms with broad therapeutic potential for the aforementioned unmet medical need. RMC-6236 exhibited potent anticancer activity across RAS-addicted cell lines, particularly those harboring mutations at codon 12 of KRAS. Notably, oral administration of RMC-6236 was tolerated in vivo and drove profound tumor regressions across multiple tumor types in a mouse clinical trial with KRASG12X xenograft models. Translational PK/efficacy and PK/PD modeling predicted that daily doses of 100 mg and 300 mg would achieve tumor control and objective responses, respectively, in patients with RAS-driven tumors. Consistent with this, we describe here objective responses in two patients (at 300 mg daily) with advanced KRASG12X lung and pancreatic adenocarcinoma, respectively, demonstrating the initial activity of RMC-6236 in an ongoing phase I/Ib clinical trial (NCT05379985).

Significance:
The discovery of RMC-6236 enables the first-ever therapeutic evaluation of targeted and concurrent inhibition of canonical mutant and wild-type RAS-GTP in RAS-driven cancers. We demonstrate that broad-spectrum RAS-GTP inhibition is tolerable at exposures that induce profound tumor regressions in preclinical models of, and in patients with, such tumors.
This article is featured in Selected Articles from This Issue, p. 897
Uma semana Carolina: mostras do manuscrito autógrafo número 11
Authors: Silva Milena Paixão 
Published: April 2024

No equilíbrio entre garantir o alimento diário para o corpo e para a alma, enquanto morou no Canindé, Carolina Maria de Jesus registrou em cadernos reaproveitados o cotidiano que a cercava. Esses escritos fazem parte de duas obras publicadas pela Editora Francisco Alves, Quarto de Despejo: diário de uma favelada (1960) e Casa de Alvenaria: diário de uma ex-favelada (1961). Diante de uma produção vastíssima, que passeia por poesia, contos, romances, peças teatrais, canções etc., e que muito ainda carece de estudos e publicação, nos interessa pensar, neste trabalho, o quanto de Carolina podemos vislumbrar através da leitura de um recorte de seus registros, compreendido por uma semana de entradas de diário correspondente ao manuscrito do caderno de número 11, que faz parte da publicação de sua primeira obra. A proposta, então, é conhecer Carolina pela escrita de Carolina, sem o intermédio dos processos de edição. Sob a ótica da Crítica Genética, que desloca a interrogação crítica da autoria para o/a escritor/a, do escrito para escritura, da estrutura para o processo e da obra para a gênese, questiona-se: o que as páginas autógrafas do caderno de número 11 de Carolina Maria de Jesus nos revelam sobre Carolina Maria de Jesus?
The Zonal Seasonal Cycle of Tropical Precipitation: Introducing the Indo-Pacific Monsoonal Mode
Authors: Tuckman P. J. , Smyth Jane , Lutsko Nicholas J. , Marshall John 
Published: April 2024

Abstract
The intertropical convergence zone (ITCZ) is associated with a zonal band of strong precipitation that migrates meridionally over the seasonal cycle. Tropical precipitation also migrates zonally, such as from the South Asian monsoon in Northern Hemisphere summer (JJA) to the precipitation maximum of the west Pacific in Northern Hemisphere winter (DJF). To explore this zonal movement in the Indo-Pacific sector, we analyze the seasonal cycle of tropical precipitation using a 2D energetic framework and study idealized atmosphere–ocean simulations with and without ocean dynamics. In the observed seasonal cycle, an atmospheric energy and precipitation anomaly forms over South Asia in northern spring and summer due to heating over land. It is then advected eastward into the west Pacific in northern autumn and remains there due to interactions with the Pacific cold tongue and equatorial easterlies. We interpret this phenomenon as a “monsoonal mode,” a zonally propagating moist energy anomaly of continental and seasonal scale. To understand the behavior of the monsoonal mode, we develop and explore an analytical model in which the monsoonal mode is advected by low-level winds, is sustained by interaction with the ocean, and decays due to the free tropospheric mixing of energy.

Significance Statement
Regional concentrations of tropical precipitation, such as the South Asian monsoon, provide water to billions of people. These features have strong seasonal cycles that have typically been framed in terms of meridional shifts of precipitation following the sun’s movement. Here, we study zonal shifts of tropical precipitation over the seasonal cycle in observations and idealized simulations. We find that land–ocean contrasts trigger a monsoon with concentrated precipitation over Asia in northern summer and near-surface eastward winds carry this precipitation into the west Pacific during northern autumn in what we call a “monsoonal mode.” This concentrated precipitation remains over the west Pacific during northern winter, as further migration is impeded by the cold sea surface temperatures (SSTs) and easterly winds of the east Pacific.
The Improvement of Short-Term Quantitative Precipitation Forecast in Mountainous Areas by the Assimilation of Meteorological State Variables Retrieved by Multiple Doppler Radar Data
Authors: Liou Yu-Chieng , Chou Tzu-Jui , Cheng Yu-Ting , Teng Yung-Lin 
Published: April 2024

Abstract
This study presents a sequential procedure formulated by combining a multiple-Doppler radar wind synthesis technique with a thermodynamic retrieval method, which can be applied to retrieve the three-dimensional wind, pressure, temperature, rainwater mixing ratio, and moisture over complex terrain. The retrieved meteorological state variables are utilized to reinitialize a high-resolution numerical model, which then carries out time integration using four different microphysical (MP) schemes, including the Goddard Cumulus Ensemble (GCE), Morrison (MOR), WRF single-moment 6-class (WSM6), and WRF double-moment 6-class (WDM6) schemes. It is found that through this procedure, the short-term quantitative precipitation forecast (QPF) skill of a numerical model over mountainous areas can be significantly improved up to 6 h. The moisture field plays a crucial role in producing the correct rainfall forecast. Since no specific microphysical scheme outperforms the others, a combination of various rainfall scenarios forecasted by different MP schemes is suggested in order to provide a stable and reliable rainfall forecast. This work also demonstrates that, with the proposed approach, radar data from only two volume scans are sufficient to improve the rainfall forecasts. This is because the unobserved meteorological state variables are instantaneously retrieved and directly used to reinitialize the model, thereby the model spinup time can be effectively shortened.
Improvement of point of care testing device for accurate whole blood glucose measurement in early neonates
Authors: Koyano Kosuke , Arioka Makoto , Nakao Yasuhiro , Morimoto Aya , Sugino Masashiro , Morita Hirosuke , Nakamura Shinji , Kondo Sonoko , Konishi Yukihiko , Yasuda Saneyuki , Kusaka Takashi 
Published: April 2024

Background It is important that blood glucose concentrations be accurately and conveniently measured in infants. However, especially in the early neonatal period, point-of-care testing devices used for adults may not accurately measure blood glucose concentrations in neonates. Methods In Study 1, the accuracy of neonatal whole-blood glucose measurements was evaluated for the existing glucose analyser Glutest Mint® (hereinafter MINT1; Sanwa Kagaku Kenkyusho, Nagoya, Japan) by comparing the data with reference blood glucose concentrations. In Study 2, we used MINT2, which was modified based on the findings from Study 1, to measure whole-blood glucose concentrations in newborns, and the accuracy of the measurements was compared with that of MINT1. Results Blood glucose concentrations were measured in 100 infants each in Study 1 and 2. In Study 1, the whole-blood glucose concentrations measured using MINT1 were found to be significantly lower than the reference blood glucose concentrations in early neonates. The results of Study 1 suggested that characteristics of erythrocyte membranes in early neonates affected the measurements. Therefore, we conducted Study 2 using MINT2, which was modified to be less susceptible. MINT2 was found to accurately measure whole-blood glucose concentrations in the early neonatal period. Conclusion The study showed that the point-of-care testing device could be improved to allow for accurate whole-blood glucose measurements in the early neonatal period.
Topical Preparations for Reducing Cutibacterium acnes Infections in Shoulder Surgery: A Systematic Review and Network Meta-analysis of Randomized Controlled Trials
Authors: Sewpaul Yash , Huynh Richard , Leung Brook , Alcock Harry , Nayar Sandeep Krishan , Rashid Mustafa S. 
Published: April 2024

Background: Cutibacterium acnes ( C acnes) is a commensal skin bacterium, primarily found in sebaceous glands and hair follicles, with a high prevalence in the shoulder region. It is the most common pathogenic organism in prosthetic joint infections after shoulder arthroplasty. Because of its low virulence, its diagnosis remains difficult. Purpose: To evaluate the relative effects of topical preparations in reducing C acnes in shoulder surgery. Study Design: Meta-analysis; Level of evidence, 1. Methods: We searched the MEDLINE, Embase, PsychINFO, and Cochrane Library databases in March 2022. Randomized controlled trials (RCTs) comparing any form of topical preparation in arthroscopic or open shoulder surgery were included. The primary outcome was a reduction in the number of positive C acnes cultures. Secondary outcomes were adverse events related to the application of topical preparations. We performed a network meta-analysis to facilitate simultaneous comparisons between multiple preparations across studies. We calculated differences between preparations using odds ratios and their 95% CIs. The risk of bias was assessed using the Cochrane risk-of-bias tool. Results: The search yielded 17 RCTs (1350 patients), of which 9 were suitable for the network meta-analysis (775 patients). Overall, 2 RCTs were deemed as having a low risk of bias, and 15 raised “some concerns” of bias. Preparations included benzoyl peroxide (BPO), BPO combined with clindamycin, chlorhexidine gluconate, hydrogen peroxide, povidone-iodine, and water with soap. Only BPO resulted in significantly lower odds of a positive C acnes culture compared with placebo or soap and water (odds ratio, 0.12 [95% CI, 0.04-0.36]). There was no statistically significant difference with all other topical preparations. The only adverse events were skin irritation from BPO and chlorhexidine gluconate in a small number of reported cases. Conclusion: BPO was the most effective topical agent in reducing the prevalence of C acnes in shoulder surgery. These results were limited by a combination of indirect and direct data. Future studies should focus on establishing the optimal frequency and duration of preoperative BPO to further reduce the burden of C acnes. Registration: CRD42022310312 (PROSPERO).
Clinical Outcomes and Graft Resorption After Metal-Free Bone Block Suture Tape Cerclage Fixation for Recurrent Anterior Shoulder Instability: A Computed Tomography Analysis
Authors: Hachem Abdul-ilah , Diaz-Apablaza Eduardo , Molina-Creixell Andres , Ruis Xavi , Videla Sebastian , Luis Agulló Jose 
Published: April 2024

Background: Glenoid reconstruction with a bone block for anterior glenoid bone loss (GBL) has shown excellent outcomes. However, fixation techniques that require metal implants are associated with metal-related complications and bone graft resorption. Hypothesis: Arthroscopic glenoid reconstruction using a tricortical iliac crest bone graft (ICBG) and metal-free suture tape cerclage fixation can safely and effectively restore the glenoid surface area in patients with recurrent anterior shoulder instability and anterior GBL. Study Design: Case series; Level of evidence, 4. Methods: Adult patients (≥18 years) of both sexes with recurrent anterior shoulder instability and anterior GBL ≥15% were enrolled. These patients underwent arthroscopic glenoid reconstruction with ICBGs and metal-free suture tape cerclage fixation. The effectiveness and clinical outcomes with this technique were evaluated at 24 months using functional scores. Resorption of the graft articular surface was assessed by computed tomography, with the graft surface divided into 6 square areas aligned in 2 columns. Descriptive analysis was conducted. Results: A total of 23 consecutive patients met inclusion criteria (22 male, 1 female; mean age, 30.5 ± 7.9 years). The mean preoperative GBL was 19.7% ± 3.4%, and there were 15 allograft and 8 autograft ICBGs. All patients exhibited graft union at 3 months. The median follow-up was 38.5 months (interquartile range, 24-45 months). The Western Ontario Shoulder Instability Index, Rowe, Constant-Murley, and Subjective Shoulder Value scores improved from preoperatively (35.1%, 24.8, 83.1, and 30.9, respectively) to postoperatively (84.7%, 91.1, 96.0, and 90.9, respectively) ( P < .001). No differences in clinical scores were observed between the graft types. One surgical wound infection was reported, and 2 patients (8.7% [95% CI, 2.4%-26.8%]) required a reoperation. The mean overall glenoid surface area increased from 80.3% ± 3.5% to 117.0% ± 8.3% immediately after surgery before subsequently reducing to 98.7% ± 6.2% and 95.0% ± 5.7% at 12 and 24 months, respectively ( P < .001). The mean graft resorption rate was 18.1% ± 7.9% in the inner column and 80.3% ± 22.4% in the outer column. Additionally, 3 patients treated with an allograft (20.0% [95% CI, 7.1%-45.2%]), including the 2 with clinical failures, exhibited complete graft resorption at the last follow-up. Conclusion: Arthroscopic glenoid reconstruction using an ICBG and metal-free suture tape cerclage fixation was safe and effective, yielding excellent clinical outcomes. Resorption of the graft articular surface predominantly affected the nonloaded areas beyond the best-fit circle perimeter.
A Case Study from the Overexpression of OsTZF5, Encoding a CCCH Tandem Zinc Finger Protein, in Rice Plants Across Nineteen Yield Trials
Authors: Grondin Alexandre , Natividad Mignon A. , Ogata Takuya , Jan Asad , Gaudin Amélie C. M. , Trijatmiko Kurniawan R. , Liwanag Evelyn , Maruyama Kyonoshin , Fujita Yasunari , Yamaguchi-Shinozaki Kazuko , Nakashima Kazuo , Slamet-Loedin Inez H. , Henry Amelia 
Published: April 2024

Abstract
Background
Development of transgenic rice overexpressing transcription factors involved in drought response has been previously reported to confer drought tolerance and therefore represents a means of crop improvement. We transformed lowland rice IR64 with OsTZF5, encoding a CCCH-tandem zinc finger protein, under the control of the rice LIP9 stress-inducible promoter and compared the drought response of transgenic lines and nulls to IR64 in successive screenhouse paddy and field trials up to the T6 generation.

Results
Compared to the well-watered conditions, the level of drought stress across experiments varied from a minimum of − 25 to − 75 kPa at a soil depth of 30 cm which reduced biomass by 30–55% and grain yield by 1–92%, presenting a range of drought severities. OsTZF5 transgenic lines showed high yield advantage under drought over IR64 in early generations, which was related to shorter time to flowering, lower shoot biomass and higher harvest index. However, the increases in values for yield and related traits in the transgenics became smaller over successive generations despite continued detection of drought-induced transgene expression as conferred by the LIP9 promoter. The decreased advantage of the transgenics over generations tended to coincide with increased levels of homozygosity. Background cleaning of the transgenic lines as well as introgression of the transgene into an IR64 line containing major-effect drought yield QTLs, which were evaluated starting at the BC3F1 and BC2F3 generation, respectively, did not result in consistently increased yield under drought as compared to the respective checks.

Conclusions
Although we cannot conclusively explain the genetic factors behind the loss of yield advantage of the transgenics under drought across generations, our results help in distinguishing among potential drought tolerance mechanisms related to effectiveness of the transgenics, since early flowering and harvest index most closely reflected the levels of yield advantage in the transgenics across generations while reduced biomass did not.
Radiomics-based discrimination of coronary chronic total occlusion and subtotal occlusion on coronary computed tomography angiography
Authors: Li Jun , Ren Lichen , Guo Hehe , Yang Haibo , Cui Jingjing , Zhang Yonggao 
Published: April 2024

Abstract
Objectives
Differentiating chronic total occlusion (CTO) from subtotal occlusion (SO) is often difficult to make from coronary computed tomography angiography (CCTA). We developed a CCTA-based radiomics model to differentiate CTO and SO.

Methods
A total of 66 patients with SO underwent CCTA before invasive angiography and were matched to 66 patients with CTO. Comprehensive imaging analysis was conducted for all lesioned vessels, involving the automatic identification of the lumen within the occluded segment and extraction of 1,904 radiomics features. Radiomics models were then constructed to assess the discriminative value of these features in distinguishing CTO from SO. External validation of the model was performed using data from another medical center.

Results
Compared to SO patients, CTO patients had more blunt stumps (internal: 53/66 (80.3%) vs. 39/66 (59.1%); external: 36/50 (72.0%) vs. 20/50 (40.0%), both p < 0.01), longer lesion length (internal: median length 15.4 mm[IQR: 10.4-22.3 mm] vs. 8.7 mm[IQR: 4.9-12.6 mm]; external:11.8 mm[IQR: 6.1-23.4 mm] vs. 6.2 mm[IQR: 3.5-9.1 mm]; both p < 0.001). Sixteen unique radiomics features were identified after the least absolute shrinkage and selection operator regression. When added to the combined model including imaging features, radiomics features provided increased value for distinguishing CTO from SO (AUC, internal: 0.772 vs. 0.846; p = 0.023; external: 0.718 vs. 0.781, p = 0.146).

Conclusions
The occluded segment vessels of CTO and SO have different radiomics signatures. The combined application of radiomics features and imaging features based on CCTA extraction can enhance diagnostic confidence.