bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fructooligosaccharides Intake during Pregnancy Improves Metabolic Phenotype of Offspring in High Fat Diet‐Induced Obese Mice
Authors: Miyamoto Junki , Ando Yuna , Nishida Akari , Yamano Mayu , Suzuki Shunsuke , Takada Hiromi , Kimura Ikuo 
Published: April 2024

ScopeObesity and metabolic diseases are closely associated, and individuals who become obese are also prone to type 2 diabetes and cardiovascular disorders. Gut microbiota is mediated by diet and can influence host metabolism and the incidence of metabolic disorders. Recent studies have suggested that improving gut microbiota through a fructooligosaccharide (FOS)‐supplemented diet may ameliorate obesity and other metabolic disorders. Although accumulating evidence supports the notion of the developmental origins of health and disease, the underlying mechanisms remain obscure.Methods and resultsICR mice are fed AIN‐93G formula‐based cellulose –, FOS–, acetate–, or propionate‐supplemented diets during pregnancy. Offspring are reared by conventional ICR foster mothers for 4 weeks; weaned mice are fed high fat diet for 12 weeks and housed individually. The FOS and propionate offspring contribute to suppressing obesity and improving glucose intolerance. Gut microbial compositions in FOS‐fed mothers and their offspring are markedly changed. However, the beneficial effect of FOS diet on the offspring is abolished when antibiotics are administered to pregnant mice.ConclusionThe findings highlight the link between the maternal gut environment and the developmental origin of metabolic syndrome in offspring. These results open novel research avenues into preemptive therapies for metabolic disorders by targeting the maternal gut microbiota.
Comparison of Chronic Sialadenitis Symptom Burden in Patients With Sialolithiasis Versus Stenosis Before and After Sialendoscopy
Authors: Bhat Amrita , Gulati Arushi , Ryan William R. , Chang Jolie L. 
Published: April 2024

AbstractObjectiveTo define symptomatology and responses to treatment in chronic sialadenitis from sialolithiasis versus duct stenosis and establish a minimal clinically significant difference (MCID) in the validated Obstructive Salivary Problem Impact Test (SPIT).Study DesignProspective, cohort.SettingTertiary‐care center.MethodsPatients completed the SPIT questionnaire at presentation and 3 to 6 months after surgery. SPIT scores and domains were compared between patients with symptomatic sialolithiasis and those with stenosis of a major salivary gland.ResultsSeventy‐nine patients completed the SPIT, including 43 (54%) with sialolithiasis and 36 (46%) with stenosis. Stenosis patients displayed greater baseline scores compared to sialolithiasis patients (45.4 ± 19.9 vs 33.3 ± 18.5, P < .013). Frequency and severity of gland swelling and pain (21.9 ± 8.9 vs 17.1 ± 9.6, P = .02) and functional/psychosocial impact subscores were greater in the stenosis versus sialolithiasis groups (18.0 ± 10.9 vs 11.3 ± 9.4, P < .01). For 43 patients who underwent surgical intervention, SPIT scores improved at 3 to 6 months postoperatively in all domains (−18.6 ± 19.4, P < .01). Degree of improvement did not differ between sialolithiasis versus stenosis groups (−22.0 ± 20.9 vs −13.3 ± 15.8, P = .13). The MCID in SPIT score was found to be −13 points. A postoperative SPIT score of less than 10 suggested symptom resolution.ConclusionWhen compared to sialolithiasis, chronic salivary obstruction from stenosis is associated with greater baseline SPIT scores, indicating poorer sialadenitis‐related quality of life due to greater symptom frequency and functional impact. Based on SPIT survey outcomes, a score decrease of 13 points or SPIT score <10 represent significant symptom improvement.
Association Between Multisensory Impairment and Depression Among Older Adults: A Population‐Based Analysis
Authors: Sacknovitz Yoni , Stein Eli , Lee Dongwon , Chen Honglei , Chern Alexander , Shiroma Eric J. , Devanand Davangere P. , Gudis David A. , Overdevest Jonathan B. 
Published: April 2024

AbstractObjectiveIn this study, we examine how impairments in vision, hearing, touch, and olfaction relate to depression in older adults, considering both individual and multisensory impairments (MSIs).Study DesignAnalysis of cross‐sectional data from a longitudinal investigation involving black and white older adults aged 70 to 79 at enrollment.SettingWe studied 1640 black and white participants in the Health ABC study using complete sensory evaluation data from years 3 to 5.MethodsOur MSI assessment utilized data obtained for visual acuity, hearing perception, olfactory performance, and tactile function. We performed multivariable logistic regression analyses to examine the associations between the presence of individual and MSIs and depression which was defined as the presence of antidepressants prescribed for depression, or a Center for Epidemiological Studies Depression Scale score of greater than 10.ResultsWe observed a possible dose‐response relationship between the number of sensory impairments and depression. In adjusted models, when compared to no impairments, vision (odds ratio [OR] = 1.45, 95% confidence interval [CI]: 1.09‐1.93) and hearing impairments (OR = 1.49, 95% CI: 1.11‐1.99) were significantly associated with depression, whereas olfaction (OR = 1.11, 95% CI: 0.83‐1.47) and tactile impairments (OR = 1.28, 95% CI: 0.96‐1.70) were not. Participants with 3 sensory impairments had a higher rate of depression (OR = 2.05, 95% CI: 1.22‐3.54) compared to those without impairments, and this risk increased further for those with 4 sensory impairments (OR = 2.95, 95% CI: 1.48‐5.88).ConclusionThe findings suggest that individuals with MSI represent a high‐risk population for depression, warranting close monitoring to screen for depression. The study emphasizes the importance of considering multiple sensory impairments in the context of mental health and supports the early identification and monitoring of depression in this population.
Bilateral Wilms tumor with anaplasia: A report from the Children's Oncology Group Study AREN0534
Authors: Romao Rodrigo L. P. , Aldrink Jennifer H. , Renfro Lindsay A. , Mullen Elizabeth A. , Murphy Andrew J. , Brzezinski Jack , Malek Marcus M. , Benedetti Daniel J. , Cost Nicholas G. , Smith Ethan , Dome Jeffrey S. , Davidoff Andrew M. , Treece Amy , Parsons Lauren N. , Fernandez Conrad V. , Tornwall Brett , Shamberger Robert C. , Paulino Arnold , Kalapurakal John A. , Geller James I. , Ehrlich Peter F. 
Published: April 2024

AbstractIntroductionThe purpose of this study is to examine the outcomes in children with anaplastic bilateral Wilms tumor (BWT) from study AREN0534 in order to define potential prognostic factors and areas to target in future clinical trials.MethodsDemographic and clinical data from AREN0534 study patients with anaplasia (focal anaplasia [FA], or diffuse anaplasia [DA]) were compared. Event‐free survival (EFS) and overall survival (OS) were reported using Kaplan–Meier estimation with 95% confidence bands, and differences in outcomes between FA and DA compared using log‐rank tests. The impact of margin status was analyzed.ResultsTwenty‐seven children who enrolled on AREN0534 had evidence of anaplasia (17 DA, 10 FA) in at least one kidney and were included in this analysis. Twenty‐six (96%) had BWT. Nineteen percent had anaplastic histology in both kidneys (four of 17 DA, and one of 10 FA). Forty‐six percent with BWT had bilateral nephron‐sparing surgery (NSS); one child who went off protocol therapy, eventually required bilateral completion nephrectomies. Median follow‐up for EFS and OS was 8.6 and 8.7 years from enrollment. Four‐ and 8‐year EFS was 53% [95% confidence interval (CI): 34%–83%] for DA; 4‐year EFS was 80% [95% CI: 59%–100%], and 8‐year EFS 70% [95% CI: 47%–100%] for FA. Three out of 10 children with FA and eight out of 17 children with DA had events. EFS did not differ statistically by margin status (p = .79; HR = 0.88). Among the six children who died (five DA, one FA), all experienced prior relapse or progression within 18 months.ConclusionEvents in children with DA/FA in the setting of BWT occurred early. Caution should be taken about interpreting the impact of margin status outcomes in the context of contemporary multimodal therapy. Future targeted investigations in children with BWT and DA/FA are needed.
Pleuroparenchymal fibroelastosis as a late complication of childhood cancer therapy: A case series
Authors: Marathe Priya H. , Santibanez Valeria , Meyers Paul A. , Padilla Maria L. , Friedman Danielle N. 
Published: April 2024

AbstractPleuroparenchymal fibroelastosis (PPFE) is a rare interstitial pneumonia with distinct clinicopathologic features. It has been associated with exposure to hematopoietic stem cell transplantation (HSCT) and classical alkylating agents. Here, we highlight PPFE as a late complication of childhood cancer therapy by describing the cases of four survivors of childhood cancer with a diagnosis of treatment‐related PPFE. All patients received high‐dose alkylating agents. PPFE should be considered in the differential diagnosis of restrictive lung disease in patients with history of exposure to alkylating agents or HSCT. Development of PPFE‐specific, noninvasive diagnostic tools and disease‐modifying therapies will clinically benefit these patients.
Bounded output‐feedback consensus‐based formation control of nonholonomic vehicles
Authors: Nuño Emmanuel , Loría Antonio , Paredes Angel I. , Hernández Tonatiuh 
Published: April 2024

AbstractIn multi‐agent systems, most commonly, consensus consists in all agents converging to a common equilibrium point. For nonholonomic vehicles, which move on a Cartesian plane and occupy a physical space, it is more appropriate to speak of consensus‐based formation, which implies that the vehicles are required to converge to a relative position in a given formation while, distributively, agreeing on the center of such formation and on their orientation. In this paper we solve such a problem via a smooth, time‐varying, output‐feedback control; more precisely, without velocity measurements. In addition, and this is our main contribution, the controller is designed to satisfy pre‐imposed bounds to avoid input saturation. To the best of the authors' knowledge this is the first controller that solves the consensus‐based formation problem in networks of nonholonomic vehicles via a bounded, output‐feedback controller. The paper also provides a simulation comparison between our proposal and its unbounded counterpart.
A Novel Approach for Synthesizing Ultra–Small Silver Nanoparticles Using Covalent Organic Frameworks as Template, Stabilizer and Reductant at Room Temperature
Authors: Yuan Ningning , Su Tong , Zhang Le , Li Dong , Li Jianye , Zhu Tingchun , Hu Junping , Guo Haobo , Liu Yirui , Liu Nana , Han Wenpeng , Yao Decui 
Published: April 2024

AbstractThe preparation of ultra–small silver nanoparticles (average diameter ≤10 nm) is a technical problem because of their aggregation tendency. Therefore, the preparation conditions are usually harsh and complex. It is widely recognized that covalent organic frameworks (COFs) represent a novel class of porous crystalline compounds with broad applications in various fields. In this work, an environmentally and economically friendly new method has been developed for synthesizing ultra–small silver nanoparticles by reducing silver ions in ethanol solution with a covalent organic framework (TPB–DMTP–COF) as a template and reductant at room temperature. Interestingly, the TPB–DMTP–COF not only serves as a template and reductant but also functions as a stabilizer. Moreover, the TPB–DMTP–COF can be utilized repeatedly as a reductant. The morphology and structure of the silver nanoparticles were examined using transmission electron microscopy and showed that they were spherical with an average particle size of approximately 7.5 nm. Compared with the previously reported silver nanoparticles, the silver nanoparticles synthesized by this new method are not coated with Surfactant, such as Polyvinylpyrrolidone (PVP). As a result, they possess a larger exposed surface area, exhibit increased activity, and demonstrate excellent antimicrobial properties against both Gram–negative Escherichia coli and Gram–positive bacteria Staphylococcus aureus.
Behavior and design of eccentrically compressed hybrid steel and GFRP reinforced concrete columns at elevated temperature
Authors: Al‐Thairy Haitham 
Published: April 2024

AbstractThis study presents analytical model for the analysis of hybrid (steel and fiber reinforced polymers (FRP)) reinforced concrete (RC) columns at elevated temperature under eccentric compressive loads. The bending moment resistance of the (RC) columns at elevated temperature is formulated based on force equilibrium and strain compatibility of the concrete column section under combined bending moment and axial force. Deterioration the mechanical properties of concrete, steel, and FRP bars due to the rise of temperature has been taken into account using equations proposed by previous studies. Validating the suggested model was carried out by comparing the analytical results with corresponding experimental and numerical results in terms of axial load‐lateral displacement relationships, axial load‐bending resistance interaction diagrams, and failure modes. Validation results have shown the accuracy of the suggested analytical model. A parametric study has also been conducted using the proposed analytical model to investigate the effect of some parameters on the axial load‐bending resistance interaction diagrams of hybrid steel and FRP‐RC columns under elevated temperature. These parameters include the effect of higher temperature values, the effect of reinforcement material, and the effect of reinforcement configuration. Parametric study results have revealed some interesting conclusions that may be implemented in the design of hybrid RC columns at fire.
Ernährungsberatung in ärztlichen Praxen verschiedener Fachrichtungen – eine Querschnittsstudie
Authors: Mertens Hannah Luisa , Kaifie Andrea 
Published: April 2024

Zusammenfassung
Hintergrund
Ziel dieser Querschnittsstudie war es, den Stand der Ernährungsberatung (EB) und Versorgung in ärztlichen Praxen zu erheben. Das entsprechende Fachwissen der Ärzt:innen sowie Hürden und Verbesserungsmöglichkeiten für die EB wurden analysiert.

Methoden
Ein Fragebogen mit 32 Items wurde erstellt und nach 2‑stufigem Pretest im Frühjahr 2022 an alle niedergelassenen Ärzt:innen der Fachrichtungen Allgemeinmedizin, Innere Medizin, Gynäkologie, Orthopädie und Arbeitsmedizin in Aachen (N = 360) verteilt.

Ergebnisse
Die Rücklaufquote lag bei 29,2 % (n = 105). 85,7 % der Ärzt:innen führten während ihrer Sprechstunde EB durch. Die Ärzt:innen schätzten, dass 39,5 % ihrer Patient:innen EB benötigten, tatsächlich beraten wurden aber nur 28,1 %. Bei Allgemeinmediziner:innen dauert die EB durchschnittlich 13 min, bei allen anderen 9,5 min. Die meisten Teilnehmer:innen fühlten sich gut über gesunde Ernährung informiert (95,2 %) und schrieben dem Thema eine hohe persönliche (57,7 %) und berufliche (47,6 %) Relevanz zu.
Die größten Hürden für eine bessere EB waren die mangelnde Vermittlung von Wissen und Kompetenzen im Medizinstudium (89,5 %) und in der Facharztweiterbildung (79,6 %) sowie Zeitmangel (75,2 %). Viele Teilnehmer:innen würden mehr EB durchführen, wenn diese Leistung besser bezahlt würde und im Arbeitsalltag mehr Zeit zur Verfügung stände.

Diskussion
Die hohe Relevanz von EB ist vielen niedergelassenen Ärzt:innen bewusst, der Bedarf an EB wird von ihnen jedoch nicht gedeckt. Um EB in ärztlichen Praxen zu fördern, bedarf es unter anderem einer besseren ernährungsmedizinischen Ausbildung, einer angemessenen Vergütung und ausreichender Zeitkontingente.
On hierarchical competition through reduction of individual growth
Authors: Barril Carles , Calsina Àngel , Diekmann Odo , Farkas József Z. 
Published: April 2024

AbstractWe consider a population organised hierarchically with respect to size in such a way that the growth rate of each individual depends only on the presence of larger individuals. As a concrete example one might think of a forest, in which the incidence of light on a tree (and hence how fast it grows) is affected by shading by taller trees. The classic formulation of a model for such a size-structured population employs a first order quasi-linear partial differential equation equipped with a non-local boundary condition. However, the model can also be formulated as a delay equation, more specifically a scalar renewal equation, for the population birth rate. After discussing the well-posedness of the delay formulation, we analyse how many stationary birth rates the equation can have in terms of the functional parameters of the model. In particular we show that, under reasonable and rather general assumptions, only one stationary birth rate can exist besides the trivial one (associated to the state in which there are no individuals and the population birth rate is zero). We give conditions for this non-trivial stationary birth rate to exist and analyse its stability using the principle of linearised stability for delay equations. Finally, we relate the results to the alternative, partial differential equation formulation of the model.
Murine Alox8 versus the human ALOX15B ortholog: differences and similarities
Authors: Palmer Megan A. , Benatzy Yvonne , Brüne Bernhard 
Published: April 2024

AbstractHuman arachidonate 15-lipoxygenase type B is a lipoxygenase that catalyzes the peroxidation of arachidonic acid at carbon-15. The corresponding murine ortholog however has 8-lipoxygenase activity. Both enzymes oxygenate polyunsaturated fatty acids in S-chirality with singular reaction specificity, although they generate a different product pattern. Furthermore, while both enzymes utilize both esterified fatty acids and fatty acid hydro(pero)xides as substrates, they differ with respect to the orientation of the fatty acid in their substrate-binding pocket. While ALOX15B accepts the fatty acid “tail-first,” Alox8 oxygenates the free fatty acid with its “head-first.” These differences in substrate orientation and thus in regio- and stereospecificity are thought to be determined by distinct amino acid residues. Towards their biological function, both enzymes share a commonality in regulating cholesterol homeostasis in macrophages, and Alox8 knockdown is associated with reduced atherosclerosis in mice. Additional roles have been linked to lung inflammation along with tumor suppressor activity. This review focuses on the current knowledge of the enzymatic activity of human ALOX15B and murine Alox8, along with their association with diseases.
Influence of atmospheric moisture on the gas evolution tolerance of halide solid electrolytes
Authors: Usami Takeshi , Tanibata Naoto , Takeda Hayami , Nakayama Masanobu 
Published: April 2024

AbstractMuch attention has been paid on research and development on solid electrolytes for all-solid-state Li batteries. Although halide solid electrolytes such as Li3YCl6 and Li3InCl6 are promising due to fast Li ion conductivity and oxidation-resistant against positive electrode, a better understanding of their reactivity with atmospheric H2O is required for commercialization. In this study, the gas evolution tolerances of Li3YCl6 and Li3InCl6 were investigated. Temperature-programmed desorption mass spectrometry (TPD-MS) experiments at dew points below − 60 °C and gas detector tube experiments at dew points of − 30 °C both revealed significant differences in the H2O and HCl evolution behavior of Li3YCl6 and Li3InCl6. In TPD-MS, the onset temperature of HCl evolution for Li3YCl6 (~ 100 °C) was significantly lower than that for Li3InCl6 (~ 220 °C), indicating that Li3InCl6 solid electrolytes have superior gas evolution tolerance. This difference may be attributable to differences in the retention of H2O derived from the material synthesis stage and from contact with the atmosphere during the measurements. In particular, based on first-principles calculations, the low-temperature HCl evolution observed in Li3YCl6 was ascribed to the partial replacement of Cl− ions by OH− ions upon contamination with trace H2O. Because the heating and drying of solid electrolytes (including slurries) are inevitable processes during battery manufacturing, these findings can aid in the rational design of halide solid electrolytes for all-solid-state batteries.
Longitudinal change of energy expenditure, body composition and dietary habits in Progressive Supranuclear Palsy patients
Authors: Tepedino Maria Francesca , Avallone Anna Rosa , Abate Filomena , Serio Marina , Caterino Miriam , Erro Roberto , Pellecchia Maria Teresa , Barone Paolo , Picillo Marina 
Published: April 2024

Abstract
Introduction
Alterations in metabolic status, body composition, and food intake are present in all neurodegenerative diseases. Aim of this study was to detect the progression of these changes in Progressive Supranuclear Palsy (PSP).

Methods
We conducted a longitudinal study of 15 patients with PSP. The assessments were performed at baseline (T0) and after 7(IQR = 5) months of follow-up (T1). We collected anthropometric measures including body weight, height, body mass index and waist circumference, metabolic parameters through indirect calorimeters, body composition using bioimpedance analysis, and dietary habits with a validated questionnaire. PSP-rating scale (PSP-rs) was used to evaluate disease severity and dysphagia.

Results
The majority of patients (66.66%) presented PSP-Richardson Syndrome and 33.33% the other variant syndromes of the disease. At T1 there was a decrease in intake of total daily calories (p < 0.001), proteins (p < 0.001), fibers (p = 0.001), calcium (p = 0.008), iron (p < 0.001), zinc (0.034), vitamin E (p = 0.006) and folates (p = 0.038) compared to T0. No other changes were found. As for T1 data, no significant differences were shown according to disease phenotypes or the presence of clinically significant dysphagia for solids.

Conclusions
Within a mid-term follow up, PSP patients presented reduced caloric and proteins intake regardless the presence of dysphagia. The PSP-rs is likely not adequate to assess dysphagia, which should be investigated by specific clinical scales or instrumental examinations. With the goal of maintaining adequate nutritional status, the administration of protein and vitamin supplements should be considered even in the absence of dysphagia evidenced by the rating scales.