bluuebunny/crossref_metadata_2025_split huggingface dataset:
The importance of pharmacist engagement in diagnostic stewardship
Authors: Claeys Kimberly C. , Morgan Daniel J. , Johnson Melissa D. 
Published: April 2024

Abstract
Diagnostic stewardship is increasingly recognized as a powerful tool to improve patient safety. Given the close relationship between diagnostic testing and antimicrobial misuse, antimicrobial stewardship (AMS) pharmacists should be key members of the diagnostic team. Pharmacists practicing in AMS already frequently engage with clinicians to improve the diagnostic process and have many skills needed for the implementation of diagnostic stewardship initiatives. As diagnostic stewardship becomes more broadly used, all infectious disease clinicians, including pharmacists, must collaborate to optimize patient care.
Understanding individual health-related social needs in the context of area-level social determinants of health: The case for granularity
Authors: Telzak Andrew , Levano Samantha , Haughton Jessica , Chambers Earle C. , Fiori Kevin P. 
Published: April 2024

Abstract

Introduction:
Screening for health-related social needs (HRSNs) within health systems is a widely accepted recommendation, however challenging to implement. Aggregate area-level metrics of social determinants of health (SDoH) are easily accessible and have been used as proxies in the interim. However, gaps remain in our understanding of the relationships between these measurement methodologies. This study assesses the relationships between three area-level SDoH measures, Area Deprivation Index (ADI), Social Deprivation Index (SDI) and Social Vulnerability Index (SVI), and individual HRSNs among patients within one large urban health system.

Methods:
Patients screened for HRSNs between 2018 and 2019 (N = 45,312) were included in the analysis. Multivariable logistic regression models assessed the association between area-level SDoH scores and individual HRSNs. Bivariate choropleth maps displayed the intersection of area-level SDoH and individual HRSNs, and the sensitivity, specificity, and positive and negative predictive values of the three area-level metrics were assessed in relation to individual HRSNs.

Results:
The SDI and SVI were significantly associated with HRSNs in areas with high SDoH scores, with strong specificity and positive predictive values (∼83% and ∼78%) but poor sensitivity and negative predictive values (∼54% and 62%). The strength of these associations and predictive values was poor in areas with low SDoH scores.

Conclusions:
While limitations exist in utilizing area-level SDoH metrics as proxies for individual social risk, understanding where and how these data can be useful in combination is critical both for meeting the immediate needs of individuals and for strengthening the advocacy platform needed for resource allocation across communities.
The military-strategic rationality of hybrid warfare: Everyday total defence under strategic non-peace in the case of Sweden
Authors: Ljungkvist Kristin 
Published: April 2024

AbstractThis article explores the emergence of new military-strategic rationalities in relation to conceptions of hybrid warfare in the grey zone through a case study of Sweden’s reinstatement of total defence since 2015. Through a governmentality-inspired approach, I analyse what it means for the organisation of a new total defence when one of the main threats to be dealt with is daily antagonistic but highly ambiguous hybrid attacks. I illustrate how conceptions of an ambiguous strategic non-peace entails a move beyond war preparedness into urgent demands for an everyday active total defence that hinges on a ‘martialisation’ of civilian life. This in turn run the risk of challenging fundamental democratic principles and civil liberties. The analysis contributes to an increased understanding and uncovering of the politics made possible by a military-strategic rationality geared towards hybrid threats in the grey zone – which in the Swedish case has resulted in a historically specific version of total defence that builds on a highly diffused and rather extreme form of decentralised defence.
Association between cortical thickness or surface area and divergent thinking in patients with bipolar disorder
Authors: Tu Pei-Chi , Chang Wan-Chen , Kuan Yi-Hsuan , Chen Mu-Hong , Su Tung-Ping 
Published: April 2024

AbstractObjective:Divergent thinking is a critical creative cognitive process. Its neural mechanisms have been well-studied through structural and functional imaging in healthy individuals but are less explored in patients with bipolar disorder (BD). Because of the traditional link between creativity and BD, this study investigated the structural correlates of divergent thinking in patients with BD through surface-based morphometry.Methods:Fifty-nine patients diagnosed with BD I or BD II (35.3 ± 8.5 years) and 56 age- and sex-matched controls (33.9 ± 7.4 years) were recruited. The participants underwent structural magnetic resonance imaging and an evaluation of divergent thinking by using the Chinese version of the Abbreviated Torrance Test for Adults (ATTA). FreeSurfer 7.0 was used to generate thickness and surface area maps for each participant. Brainwise regression of the association between cortical thickness or surface area and ATTA performance was conducted using general linear models.Results:Divergent thinking performance did not differ significantly between the patients with BD and the healthy controls. In these patients, total ATTA score was negatively correlated with cortical thickness in the right middle frontal gyrus, right occipital, and left precuneus but positively correlated with the surface area of the right superior frontal gyrus. By contrast, total ATTA scores and cortical thickness or surface area were not significantly correlated among the controls.Conclusion:The findings indicate that divergent thinking involves cerebral structures for executive control, mental imagery, and visual processing in patients with BD, and the right prefrontal cortex might be the most crucial of these structures.
Termitaria enhance soil and forest diversity in Deciduous Dipterocarp Forest, Northern Thailand
Authors: Kaewfoo Manop , Bunyavejchewin Sarayudh , Marod Dokrak , Wiwatwittaya Decha , Baillie Ian C. , Davies Stuart J. , Hallett Stephen H. 
Published: April 2024

Abstract
We characterised the soils and vegetation in 15 sets of four quadrats on and around mounds of Macrotermes annandalei (Isoptera, Macrotermitinae) on a plain of deep dystric clay over limestone in Deciduous Dipterocarp Forest in Northern Thailand. Termites have excavated the mounds from the deep calcareous substrate. The mound soils have darker subsoils, larger contents of clays and exchangeable cations, and higher pH values than the surrounding dystric clay loams. The thickets on the mounds are visually different from the surrounding Deciduous Dipterocarp Forest. They have few dipterocarps and are floristically similar to the regionally important Mixed Deciduous Forest. The clear visual differences are confirmed by floristic similarity, cluster, and canonical correspondence analyses for each of the tree, sapling and seedling size classes. The differences between the mound clays and surrounding red clay loams and the associations between soil and forest types are confirmed by ‘t tests’ and the significant correlations of the soil base status with the main floristic axis of the canonical correspondence analyses. Soil variability due to termites and other agents of pedoturbation can significantly contribute to short-range floristic and structural diversity in some dry tropical forests.
A genetically related cluster of Salmonella Typhimurium cases in humans associated with ruminant livestock and related food chains, United Kingdom, August 2021–December 2022
Authors: Merrick Rachel , Pulford Caisey , Rubeshkumar Polani , Seyan Parnam , Fina Laia , Sawyer Clare , Pacchiarini Nicole , Pollock Carrie , Lighthill Jonathan , Potter Tina , Harvey Nathan , Thomas Kara , Lloyd Daniel , Gherman Iulia , Mackintosh Adrienne , Lawes Joanna , Snow Lucy , Waldram Alison , Larkin Lesley , Balasegaram Sooria , Painset Anais , McCormick Jacquelyn , Elson Richard , Browning Lynda , Williams Christopher , Andrew Rachel , Mably Susan , Thomas Daniel 
Published: April 2024

Abstract
Following an outbreak of Salmonella Typhimurium in Wales in July 2021 associated with sheep meat and offal, further genetically related cases were detected across the UK. Cases were UK residents with laboratory-confirmed Salmonella Typhimurium in the same 5-single-nucleotide polymorphism (SNP) single-linkage cluster with specimen date between 01/08/2021–2031/12/2022. We described cases using routine (UK) and enhanced (Wales only) surveillance data. Exposures in cases in Wales were compared with non-Typhimurium Salmonella case–controls. Environmental Health Practitioners and the Food Standards Agency investigated supply chains of food premises reported by ≥2 cases. Animal, carcass, and environmental samples taken for diagnostic or monitoring purposes for gastrointestinal pathogens were included in microbiological investigations. We identified 142 cases: 75% in England, 23% in Wales and 3% in Scotland. Median age was 32 years, and 59% were male. Direct contact with sheep was associated with becoming a case (aOR: 14, 95%CI: 1.4–145) but reported by few (6/32 cases). No single food item, premises, or supplier linked all cases. Multi-agency collaboration enabled the identification of isolates in the same 5-SNP single-linkage cluster from a sheep carcass at an English abattoir and in ruminant, wildlife, poultry, and environmental samples, suggesting multiple vehicles and pathways of infection.
Projecting Global Mercury Emissions and Deposition Under the Shared Socioeconomic Pathways
Authors: Geyman Benjamin M. , Streets David G. , Thackray Colin P. , Olson Christine L. , Schaefer Kevin , Sunderland Elsie M. 
Published: April 2024

AbstractMercury (Hg) is a naturally occurring element that has been greatly enriched in the environment by human activities like mining and fossil fuel combustion. Despite commonalities in some carbon dioxide (CO2) and Hg emission sources, the implications of long‐range climate scenarios for anthropogenic Hg emissions have yet to be explored. Here, we present comprehensive projections of anthropogenic Hg emissions extending to the year 2300 and evaluate impacts on global atmospheric Hg deposition. Projections are based on four Shared Socioeconomic Pathways (SSPs) ranging from sustainable reductions in resource and energy intensity to rapid economic growth driven by abundant fossil fuel exploitation. There is a greater than two‐fold difference in cumulative anthropogenic Hg emissions between the lower‐bound (110 Gg) and upper‐bound (235 Gg) scenarios. Hg releases to land and water are approximately six times those of direct emissions to air (600–1,470 Gg). At their peak, anthropogenic Hg emissions reach 2,200–2,600 Mg a−1 sometime between 2010 (baseline) and 2030, depending on the SSP scenario. Coal combustion is the largest determinant of differences in Hg emissions among scenarios. Decoupling of Hg and CO2 emission sources occurs under low‐to mid‐range scenarios, though contributions from artisanal and small‐scale gold mining remain uncertain. Future Hg emissions may have lower gaseous elemental Hg (Hg0) and higher divalent Hg (HgII), resulting in a higher fraction of locally sourced Hg deposition. Projected reemissions of previously deposited anthropogenic Hg follow a similar temporal trajectory to primary emissions, amplifying the benefits of primary Hg emission reductions under the most stringent mitigation scenarios.
Improving Mercury Systematics With Molybdenum and Vanadium Enrichments: New Insights From the Cambrian‐Ordovician Boundary
Authors: Bian Leibo , Chappaz Anthony , Wang Xiaomei , Amouroux David , Schovsbo Niels Hemmingsen , Zheng Xiaowei , Sanei Hamed 
Published: April 2024

AbstractThe Cambro‐Ordovician interval marks a significant transition from extinction to bio‐diversification in deep time. However, the relationship of bio‐transition to volcanism, commonly characterized by mercury (Hg) systematics in sedimentary records, has not been examined. We present the first Cambro‐Ordovician Hg systematics from the Scandinavian Alum Shale. Our results show pronounced Furongian Hg enrichments, coupled with positive Δ199Hg, Δ200Hg, and Δ201Hg values and negative Δ204Hg values that we ascribe to atmospheric Hg transport over long‐distances, while Early Ordovician Hg anomalies, characterized by near‐zero mass‐independent isotope values, indicative of submarine source. Our findings are supported by two new proxies: molybdenum‐Hg and vanadium‐δ202Hg co‐variations, demonstrating Hg systematics were strongly influenced by changes in source and depositional conditions. Constrained by a synchronous atmospheric‐tectonic‐oceanic model, we hypothesize Furongian subaerial volcanism contributed to global extinction and oceanic anoxia, whereas Early Ordovician submarine volcanism concurrent with ocean water upwelling promoted the nascent bio‐diversification.
Characteristics of Daytime‐And‐Nighttime AOD Differences Over China: A Perspective From CALIOP Satellite Observations and GEOS‐Chem Model Simulations
Authors: Jiang Xiaodong , Wang Yi , Wang Lunche , Tao Minghui , Wang Jun , Zhou Meng , Bai Xuehui , Gui Lu 
Published: April 2024

AbstractWe use the GEOS‐Chem chemistry transport model to quantify the factors in the diel discrepancy of Aerosol Optical Depth (AOD) retrieved from Cloud‐Aerosol Lidar with Orthogonal Polarization (CALIOP) satellite observations over eastern China. The GEOS‐Chem simulation reveals that the AOD below 1 km is 58.5% larger at night than during the daytime, which is comparable to the counterpart of 41.3% from CALIOP (v4.2). Model sensitivity simulations show that the diurnal variation in wind barely impacts the AOD difference between daytime and nighttime, and the increase in AOD at nighttime is primarily caused by the lower temperature at nighttime compared to daytime. Further simulations demonstrate that the low temperature at night increases AOD primarily by increasing relative humidity, and hence particle hygroscopic growth, while the effect of temperature on chemical rate barely influences AOD. CALIOP also observes that the absolute difference in AOD above 1 km between nighttime and daytime is 0.105, while the counterpart in GEOS‐Chem simulations is −0.031. This contrast can be partly explained by the factor that the percentage of valid CALIOP retrievals below 5 km is 15%–20% greater at nighttime than in the daytime due to the CALIOP detection limit. Removing the detection limit impact decreases the difference in the CALIOP AOD above 1 km between nighttime and daytime to 0.073.
Glacier‐Fed Lakes Are Significant Sinks of Carbon Dioxide in the Southeastern Tibetan Plateau
Authors: Zhu Meizhuang , Kuang Xingxing , Song Chunlin , Feng Yuqing , He Qiule , Zou Yiguang , Zhou Hui , Zheng Chunmiao 
Published: April 2024

AbstractDissolved inorganic carbon (DIC) sources, transportation, and transition in inland water bodies have been intensively studied due to their important role in the global carbon cycle. While glacier‐fed lakes play a crucial role in global carbon cycling, related studies are limited. In this study, we investigated the spatiotemporal variability of DIC in the maritime glacier‐fed lakes of the southeastern Tibetan Plateau, identifying the carbon sources and potential controlling factors of DIC pathways The results revealed significant temporal variations in DIC and δ13C‐DIC, with averages of 7.29 ± 0.45 mg C L−1 and –8.6 ± 0.2‰ in summer, and 3.40 ± 0.54 mg C L−1 and –7.4 ± 0.6‰ in winter, respectively. Temporal variations in DIC and δ13C‐DIC were mainly controlled by carbonates weathering and silicate weathering processes. The chemical weathering reactions facilitate the consumption of dissolved CO2. Undersaturated pCO2 (120.02 ± 29.18 μatm) relative to atmospheric equilibrium suggests considerable capacity for CO2 uptake within glacier‐fed lakes system. We estimated that the maritime glacier‐fed lakes in the southeastern Tibetan Plateau absorb a total of 9.6 ± 2.7 × 10−3 Tg C‐CO2 yr−1, highlighting their significant contribution to the global carbon budget. The distinctive landscape of the glacier‐fed system and the vulnerable weathering environment result in seasonal and spatial variations of DIC concentration and δ13C‐DIC values, as well as the chemical weathering‐induced CO2 sink in glacier regions. Given the accelerated glacier retreat observed in this area, further studies on the temporal variability of DIC in the water column are urgently needed to identify the mechanisms driving the biogeochemical reactions inside glacier‐fed lake. Our study highlights the unrecognized role of maritime glacier‐fed lakes as CO2 sinks and emphasizes their significance in regional carbon budgets.
Recreating Observed Convection‐Generated Gravity Waves From Weather Radar Observations via a Neural Network and a Dynamical Atmospheric Model
Authors: Kruse C. G. , Alexander M. J. , Bramberger M. , Chattopadhyay A. , Hassanzadeh P. , Green B. , Grimsdell A. , Hoffmann L. 
Published: April 2024

AbstractConvection‐generated gravity waves (CGWs) transport momentum and energy, and this momentum is a dominant driver of global features of Earth's atmosphere's general circulation (e.g., the quasi‐biennial oscillation, the pole‐to‐pole mesospheric circulation). As CGWs are not generally resolved by global weather and climate models, their effects on the circulation need to be parameterized. However, quality observations of GWs are spatiotemporally sparse, limiting understanding and preventing constraints on parameterizations. Convection‐permitting or ‐resolving simulations do generate CGWs, but validation is not possible as these simulations cannot reproduce the CGW‐forcing convection at correct times, locations, and intensities. Here, realistic convective diabatic heating, learned from full‐physics convection‐permitting Weather Research and Forecasting simulations, is predicted from weather radar observations using neural networks and a previously developed look‐up table. These heating rates are then used to force an idealized GW‐resolving dynamical model. Simulated CGWs forced in this way closely resembled those observed by the Atmospheric InfraRed Sounder in the upper stratosphere. CGW drag in these validated simulations extends 100s of kilometers away from the convective sources, highlighting errors in current gravity wave drag parameterizations due to the use of the ubiquitous single‐column approximation. Such validatable simulations have significant potential to be used to further basic understanding of CGWs, improve their parameterizations physically, and provide more restrictive constraints on tuning with confidence.
Secondary Ice Production Improves Simulations of Freezing Rain
Authors: Cholette Mélissa , Milbrandt Jason A. , Morrison Hugh , Kirk Sabrina , Lalonde Louis‐Émile 
Published: April 2024

AbstractWeather forecasts and climate projections of precipitation phase and type in winter storms are challenging due to the complicated underlying microphysical and dynamical processes. In the Canadian numerical weather prediction model, explicit freezing rain (FR) at the surface is often overestimated during the winter season for situations in which snow is observed. For a case study simulated using this model with the Predicted Particle Properties (P3) microphysics scheme, the secondary ice production (SIP) process has a major impact on the surface precipitation type. Parameterized SIP substantially reduces FR due to increased collection of supercooled drops with ice particles formed by rime splintering. Hindcast simulations of 40 winter cases show that these results are systematic, and the decreased frequency of FR leads to improved forecast skill relative to observations. Thus, accounting for SIP in the model is critical for accurately simulating precipitation types.
Overcoming BRAF and CDK4/6 inhibitor resistance by inhibiting MAP3K3-dependent protection against YAP lysosomal degradation
Authors: Park Sanghyun , Ryu Won-Ji , Kim Tae Yeong , Hwang Yumi , Han Hyun Ju , Lee Jeong Dong , Kim Gun Min , Sohn Joohyuk , Kim Sang Kyum , Kim Min Hwan , Kim Joon 
Published: April 2024

AbstractTranscriptional programs governed by YAP play key roles in conferring resistance to various molecular-targeted anticancer agents. Strategies aimed at inhibiting YAP activity have garnered substantial interest as a means to overcome drug resistance. However, despite extensive research into the canonical Hippo–YAP pathway, few clinical agents are currently available to counteract YAP-associated drug resistance. Here, we present a novel mechanism of YAP stability regulation by MAP3K3 that is independent of Hippo kinases. Furthermore, we identified MAP3K3 as a target for overcoming anticancer drug resistance. Depletion of MAP3K3 led to a substantial reduction in the YAP protein level in melanoma and breast cancer cells. Mass spectrometry analysis revealed that MAP3K3 phosphorylates YAP at serine 405. This MAP3K3-mediated phosphorylation event hindered the binding of the E3 ubiquitin ligase FBXW7 to YAP, thereby preventing its p62-mediated lysosomal degradation. Robust YAP activation was observed in CDK4/6 inhibitor-resistant luminal breast cancer cells. Knockdown or pharmacological inhibition of MAP3K3 effectively suppressed YAP activity and restored CDK4/6 inhibitor sensitivity. Similarly, elevated MAP3K3 expression supported the prosurvival activity of YAP in BRAF inhibitor-resistant melanoma cells. Inhibition of MAP3K3 decreased YAP-dependent cell proliferation and successfully restored BRAF inhibitor sensitivity. In conclusion, our study reveals a previously unrecognized mechanism for the regulation of YAP stability, suggesting MAP3K3 inhibition as a promising strategy for overcoming resistance to CDK4/6 and BRAF inhibitors in cancer treatment.
Loss of SREBP-1c ameliorates iron-induced liver fibrosis by decreasing lipocalin-2
Authors: Lee Eun-Ho , Lee Jae-Ho , Kim Do-Young , Lee Young-Seung , Jo Yunju , Dao Tam , Kim Kyung Eun , Song Dae-Kyu , Seo Ji Hae , Seo Young-Kyo , Seong Je Kyung , Moon Changjong , Han Eugene , Kim Mi Kyung , Ryu Seungwan , Shin Minsang , Roh Gu Seob , Jung Hye Ra , Osborne Timothy F. , Ryu Dongryeol , Jeon Tae-Il , Im Seung-Soon 
Published: April 2024

AbstractSterol regulatory element-binding protein (SREBP)-1c is involved in cellular lipid homeostasis and cholesterol biosynthesis and is highly increased in nonalcoholic steatohepatitis (NASH). However, the molecular mechanism by which SREBP-1c regulates hepatic stellate cells (HSCs) activation in NASH animal models and patients have not been fully elucidated. In this study, we examined the role of SREBP-1c in NASH and the regulation of LCN2 gene expression. Wild-type and SREBP-1c knockout (1cKO) mice were fed a high-fat/high-sucrose diet, treated with carbon tetrachloride (CCl4), and subjected to lipocalin-2 (LCN2) overexpression. The role of LCN2 in NASH progression was assessed using mouse primary hepatocytes, Kupffer cells, and HSCs. LCN2 expression was examined in samples from normal patients and those with NASH. LCN2 gene expression and secretion increased in CCl4-induced liver fibrosis mice model, and SREBP-1c regulated LCN2 gene transcription. Moreover, treatment with holo-LCN2 stimulated intracellular iron accumulation and fibrosis-related gene expression in mouse primary HSCs, but these effects were not observed in 1cKO HSCs, indicating that SREBP-1c-induced LCN2 expression and secretion could stimulate HSCs activation through iron accumulation. Furthermore, LCN2 expression was strongly correlated with inflammation and fibrosis in patients with NASH. Our findings indicate that SREBP-1c regulates Lcn2 gene expression, contributing to diet-induced NASH. Reduced Lcn2 expression in 1cKO mice protects against NASH development. Therefore, the activation of Lcn2 by SREBP-1c establishes a new connection between iron and lipid metabolism, affecting inflammation and HSCs activation. These findings may lead to new therapeutic strategies for NASH.