bluuebunny/crossref_metadata_2025_split huggingface dataset:
Indonesian orthodontists and laypeople’s perception of the four components of smile analysis in individuals with various vertical skeletal patterns
Authors: Subono Mutiara , Soegiharto Benny M. , Anggani Haru Setyo 
Published: April 2024

Objectives:
The objective of this study was to analyze the difference towards orthodontists’ and laypeople’s perceptions of four smile analysis components in individuals with various vertical skeletal patterns.

Material and Methods:
Each of the 100 orthodontists, and laypeople aged 26–65 years old were asked to complete an online questionnaire about four smile analysis components in individuals with various vertical skeletal patterns. The questionnaire consists of 36 modified photos according to various smile curves, buccal corridors, gingival displays, and incisor displays in normal, hypodivergent, and hyperdivergent skeletal patterns. Perceptions were assessed using a visual analog scale.

Results:
Significant differences were found in straight and parallel smile curve, maximum buccal corridor, and gingival display 4 mm components in all vertical skeletal patterns. Additionally, differences were also found in the medium buccal corridor in hypodivergent skeletal pattern, gingival display 2 mm in normal and hypodivergent skeletal patterns. Moreover, significant differences were also observed in the 100% incisor display in normal vertical skeletal pattern, and 50% incisor display in hyperdivergent skeletal pattern

Conclusion:
Orthodontists and laypeople have similar perceptions toward the most esthetic components (parallel smile curve, minimum buccal corridor, gingival display 0 mm, and incisor display 75%) in all vertical skeletal patterns.
Evaluation of the effectiveness and safety of erector spinae plane block during coronary artery bypass surgery: a randomized clinical trial
Authors: Paromov K. V. , Svirskii D. A. , Kirov M. Yu. 
Published: April 2024

The search for a method of perioperative pain control after coronary bypass surgery is relevant both from the point of view of safety and effectiveness of the methods used.Aim: To evaluate the hemodynamic changes and effectiveness of erector spinae plane block (ESPB) for off-pump coronary artery bypass surgery.Methodology and research methods. The prospective randomized single-center study included 45 patients equally distributed according to the applied methods of perioperative analgesia into 3 groups: general anesthesia with epidural anesthesia (GA + EA group, n = 15), general anesthesia with ESPB (GA + ESPB group, n = 15) and general anesthesia without any regional anesthesia techniques (GA group, n = 15). Assessment of hemodynamics and severity of pain syndrome was performed during the first postoperative day.Results. The intraoperative dose of fentanyl was 0.4 (0.4–0.5) mg in the GA + EA group, and 0.4 (0.3–0.4) mg in the GA + ESPB group that is significantly less than in the GA group – 1.1 (1.0–1.1) mg (p < 0.001). Postoperatively, the dose of fentanyl was 0.10±0.04 mg in the GA + EA group and 0.23±0.05 mg in the GA group (p < 0.001), whereas in the ESPB group fentanyl was not used. The pain level assessed by the numeric rating scale (NRS) was 3.0 (2.0–4.0) points at one hour after tracheal extubation and 3.0 (0.5–3.5) points at the end of the first day of the postoperative period without difference between the groups. The systemic and pulmonary hemodynamics, respiratory and vasopressor support did not differ as well.Conclusion. The use of regional anesthesia (EA and ESPB) provides similar quality of perioperative analgesia like general anesthesia, but leads to reduction in opioid doses. Postoperatively, the use of ESPB does not lead to a deterioration of the hemodynamic status of the patient.
Features of chronic heart failure on the background of thrombocytopenia in persons infected with the human immunodeficiency virus
Authors: Goryacheva O. G. 
Published: April 2024

The general context of the study is to review the characteristics of the course of chronic heart failure (CHF) in persons infected with the human immunodeficiency virus (HIV) as a part of a single-stage screening clinical trial.Aim: To determine the features of the CHF course in HIV-infected patients, depending on the presence of thrombocytopenia (TP).Material and Methods. In a multidisciplinary hospital, 240 patients with HIV infection were examined for four years, where a cohort of patients with CHF (160 people) was identified, further divided into groups of patients with TP (107 people) and without TP (53 people). Patients underwent the same amount of research, including echocardiography, non-invasive arteriography, and a detailed laboratory examination.Results. TP in patients with CHF and HIV infection is more common in smokers and people with alcohol dependence and is associated with hemodynamic disorders in the form of higher systolic and diastolic blood pressure, left atrium increase. With TP, the values of NT-proBNP in blood plasma are higher, and in the blood serum – tissue inhibitor of metalloproteinases-1, urea, bilirubin, while the concentration of sodium and potassium ions in the blood serum is lower. Anemia and leukopenia were more common in the group of patients with thrombocytopenia. Patients with TP are more adherent to taking protease inhibitors and non-steroidal anti-inflammatory drugs.Conclusion. The frequency of CHF detection in patients with HIV infection against the background of TP is almost 2 times higher and is more often accompanied by dilatation of the left atrium, higher blood pressure, an increase in TIMP-1 and a decrease in the concentration of potassium ions in the blood serum. The concentration of NT-proBNP in blood plasma has a close inverse correlation with the number of platelets in patients with CHF and TP, and the presence of severe TP ≤ 30 × 109 cells/l increases the chances of developing CHF with low left ventricular ejection fraction by 10.8 times. Smoking, possible alcohol dependence and adherence to taking protease inhibitors and NSAIDs are significant factors associated with the development of thrombocytopenia in HIV-infected patients with CHF.
Changes in the level of some tryptophan metabolites in the blood of patients with type 2 diabetes mellitus complicated by diabetic retinopathy
Authors: Saklakova О. A. , Maksimenya M. V. , Fefelova E. V. , Tereshkov P. P. , Karavaeva T. M. 
Published: April 2024

Aim: To study the content of tryptophan and the intermediate metabolites of kynurenine and serotonin pathways of its metabolism in the blood plasma of patients with type 2 diabetes mellitus (DM) and non-proliferative diabetic retinopathy as candidates for markers of the early stage of the pathological process.Material and Methods. Three groups of people were analyzed: the first group of 10 patients with type 2 diabetes mellitus and without diabetic retinopathy; the second group of 10 people with type 2 diabetes mellitus and non-proliferative stage of diabetic retinopathy; and the control group of 10 healthy people. The features of the first group were a decrease of macula’s photosensitivity in the fundus and a slight increase in the central thickness of the retina. Patients with diabetic retinopathy tended to have a moderate number of microaneurysms and microhemorrhages, moderately presented intraretinal microvascular anomalies in one quadrant, vein dilatation, clearness of the central retinal vein and its branches. In the macular zone there was an edema with hard exudates in the center and lateral to the fovea centralis. All participants of the study gave blood on an empty stomach in the morning, and after that in we measured the content of tryptophan (TRP), kynurenins ((kynurenine (KYN), 3-hydroxykynurenine (3-HKYN), kynurenic acid (KYNA)) and the level of L-5-hydroxytyrptophan (5HTrp) in blood plasma by HPLC method with fluorimetric and spectrophotometric detection.Results. The groups of people with type 2 diabetes mellitus showed the increasing of TRP level in blood relatively to healthy individuals: by 15.1% (p = 0.032) and 17.9% (p = 0.030) in the first and second groups, respectively. As for the patients of the first group, the content of their KYN was increased by 57.7% (p = 0.012) and KYNA by 33.6% (p = 0.012) relatively to the control and the concentration of 3-НKYN decreased by 18.1% (p = 0.020) relatively to healthy people. As for the patients in the second group, the changes in their level of kynurenines had the same direction, but were more visible. Thus, the concentration of KYN exceeded the same parameters of healthy individuals by 84.5% (p = 0.001) and the parameters of the first group by 18.0% (p = 0.049); the KYNA level increased by 56.6% (p = 0.001) relatively to the control and by 17.3% (p = 0.049) from that of the first group. There was a decrease in the content of 3-HKYN amounted to 18.6% of the control (p = 0.038) and an increase in the concentration of 5HTrp – 193,9% (p < 0.001).
The effect of physical activity of varying intensity on cardiomyocyte hypertrophy and myocardial polyploidy in rats
Authors: Malyshev I. I. , Alpidovskaya O. V. , Romanova L. P. 
Published: April 2024

Regular exercise improves cognitive function, reduces the risk of premature death from cardiovascular disease, stroke, diabetes and improves quality of life.Aim: To study the morphological parameters of cardiomyocytes of the left ventricle of the heart and the proliferative activity of rat cardiomyocytes during physical activity of different intensity.Methodology and Research Methods. Outbred male rats (n = 30) were taken as experimental animals and divided into three series. The first series of rats were given light physical activity – the animals swam in the bath for 15 minutes. The animals of the second series were in the bath for 30 minutes (moderate severity), the third series were in the bath until they began to lose strength and sink (in 55–59 minutes). Animals were taken out of the experiment after 10 sessions of water loading. Some rats (5 animals per series) were slaughtered 30 days after the end of the experiment. After extraction, the heart was stained with hematoxylin and eosin, the amount of DNA in the nuclei of cardiomyocytes was determined, binuclear and Ki-67 positive cells were counted, and the diameter of cardiomyocytes was measured. Statistical analysis was carried out in the program “Statistica 10.0”.Results. Histological examination revealed changes only in the myocardium of the left ventricle of rats of the third series: pronounced dystrophic changes in cardiomyocytes. There were cells with necrobiosis, focal necrosis of groups of cardiomyocytes. The highest level of cardiomyocyte polyploidy occurred in the second and third series (the ratio of diploid and tetraploid cardiomyocytes in the control corresponded to 91.6 ± 7.4%; 8.2±6.3%). In these series, there was also a change in the number of binuclear cells (in the control – 12.7 ± 1.9‰). In all series of Ki-67 positive nuclei were not detected.Conclusion. Severe physical activity leads to structural disorders of the myocardium, persistent hypertrophy of cardiomyocytes and is accompanied by a decrease in the proliferative activity of cardiomyocytes.
Experimental models of myocardial ischemia: classical approaches and innovations (review)
Authors: Slatova L. N. , Fedorina T. A. , Shatunova E. P. 
Published: April 2024

Myocardial ischemia is the basis for many acute and chronic conditions with great social significance. Therefore, experimental models that describe ischemia development in humans are necessary for a better understanding of the pathophysiology of these conditions and the development of medical and surgical methods of treatment.Aim: To compare current approaches to experimental modeling of myocardial ischemia considering the pathogenetic features of the simulated processes. The manuscript describes the main experimental models of myocardial ischemia: in vitro cellular models, ex vivo isolated heart models, in vivo animal models, the principal components of the ‘heart-on-chip’ model and the possibilities of in silico modeling. The criteria for choosing a specific model of ischemia by pathophysiological approach, advantages and limitations of the models are considered.
Long-term outcomes in patients with type 1 and type 2 myocardial infarction (data from a single-center register study)
Authors: Kinash V. I. , Kashtalap V. V. , Fedorov D. A. , Vorobiev A. S. , Urvantseva I. A. , Kovalenko L. V. 
Published: April 2024

Aim: To study the annual outcomes of patients with a confirmed diagnosis of myocardial infarction (MI), depending on its type.Material and Methods. Of the 1,325 hospitalized patients, 1,293 (97.5%) were diagnosed with acute coronary syndrome; the rest had extra-cardiac causes of chest pain. Follow-up included examinations of patients in the hospital and interviewing by phone or email in 12 months after discharge. All patients with MI were tested for the presence of personality type D. After 12 months of follow-up, the total number of patients diagnosed with MI was 255 (92.1%) patients [180 (70.5%) patients with MI1, 75 (29.5%) patients with MI2].Results. After 12 months of follow-up, in the general group of patients complications developed in 53 (20.7%) patients (27 (15.0%) patients in the IM1 group and 26 (34.6%) patients in the IM2 group). Overall mortality and the frequency of repeat- ed hospitalizations for heart failure were higher in MI2 compared to MI1 [8 (10.6%) vs. 2 (1.1%) (p = 0.001) and 9 (12.0%) vs. 8 (4.4%) (p = 0.03), respectively]. The main predictors of adverse events in patients with MI2 were: obesity, p = 0.005; diabetes mellitus, p = 0.006; two-vessel lesion, p = 0.001; three-vessel lesion, р = 0.001; low adherence to drug therapy (< 6 points) on the Morisky-Green scale, p = 0.007; personality type D, p = 0.040. In patients with MI1, the main predictors of adverse events were: obesity, p = 0.019; male, p = 0.009. There were no statistically significant differences in both groups in the frequency of mortality from MI, the development of recurrent MI, as well as complications such as subacute/late stent thrombosis and restenosis in the stent.Conclusion. In patients with MI2, compared with MI1, after 12 months of follow-up the indicators of total mortality (10.6% vs. 1.1%) and repeated hospitalizations due to decompensation of heart failure (12% vs. 4.4%) are higher.
Rationale and design of a prospective randomized study of the effect of ferric carboxymaltose therapy on quality of life and clinical picture of heart failure with preserved ejection fraction in patients with iron deficiency
Authors: Tukish O. V. , Garganeeva A. A. , Kuzheleva E. A. , Soldatenko M. V. , Kondratiev M. Yu. , Vitt K. N. 
Published: April 2024

Introduction. The prevalence of iron deficiency (ID) among patients with chronic heart failure (CHF) ranges from 50% to 80%. It has been established that ID is a significant predictor of adverse outcomes and mortality in CHF, and is also associated with a decrease in exercise tolerance. The use of oral iron preparations for the purpose of its correction is limited by the high frequency of adverse events and, in some cases, their ineffectiveness in CHF. Ferric carboxymaltose has a high potential in the correction of ID, which has proven itself well in the cohort of patients with CHF, but its effectiveness has not been precisely established in CHF.Aim: To evaluate the effect of ferric carboxymaltose therapy on the quality of life, functional status, and clinical picture of CHF in patients with diagnosed iron deficiency.Material and Methods. It is a prospective randomized cohort study. It is planned to include 70 adult patients with CHF (NYHA II-III) and diagnosed ID: group 1 (n = 35) – group of drug therapy with ferric carboxymaltose, group 2 (n = 35) – without drug therapy. A control group of patients without ID (n = 30) will also be recruited. The prospective part involves the observation of patients with repeated visits after 6, 12 months, during which the indicators of quality of life, functional status, clinical picture of CHF, structural and functional echocardiographic indicators of LV and right heart, as well as the presence of repeated hospitalizations for CHF and death from all causes will be evaluated.
Clinical significance of echocardiographic signs of right heart dysfunction in patients with chronic heart failure with preserved left ventricular ejection fraction
Authors: Vitt K. N. , Kuzheleva E. A. , Tukish O. V. , Soldatenko N. V. , Kondratiev M. Yu. , Kirillova V. V. , Antipov S. I. , Garganeeva A. A. 
Published: April 2024

Aim:To analyze the features of clinical signs, quality of life and psycho-emotional state in patients with heart failure with preserved left ventricular ejection fraction (HFpEF) and non-obstructive atherosclerosis of the coronary arteries, depending on the presence of echocardiographic criteria for dysfunction of the right heart.Material and Methods.Patients underwent an extended protocol of echocardiography with an assessment of the structure and function of the right heart; ultrasound examination of the lungs with the determination of the number of B-lines; a six-minute walk test, a test for the presence of a symptom of bendopnea with the determination of blood oxygen saturation (SpO2) before and during the test. In addition, quality of life was assessed using the Minnesota questionnaire and the SF-36 questionnaire (The Short Form-36); the psycho-emotional state of patients was analyzed according to the HADS (Hospital Anxiety and Depression Scale), the level of adherence to treatment was analyzed according to the Morisky – Green questionnaire. Patients were divided into two groups depending on signs of right heart dysfunction: Tei index more than 0.54, tricuspid annulus systolic excursion (TAPSE) less than 17 mm, tricuspid annulus systolic velocity (RV S’) less than 9,5 cm/sec.Results.Echocardiographic signs of right heart dysfunction in patients with HFpEF was associated with lower quality of life indicators according to the SF-36 questionnaire, in particular, general health status (p= 0.008) and role limitations due to emotional problems (p= 0.03). During the bendopnea test (p= 0.04), the majority of patients with signs of dysfunction of the right heart (66.7%) had a decrease in SpO2, while in the comparison group the proportion of such patients was 36.7% (p= 0.04). The psycho-emotional state according to the HADS scale and adherence to treatment did not differ in both groups (p> 0.05). The frequency of detection of B-lines according to lung ultrasound was also comparable.
Integrating Answer Literals with AVATAR for Program Synthesis
Authors: Hozzová Petra 
Published: April 2024

We recently introduced a framework for program synthesis based on functional specifications using a saturation-based theorem prover.To make our synthesis technique efficient, we need to incorporate it into the prover's architecture.In this paper, we describe the considerations of integrating our synthesis technique with the AVATAR splitting framework used in first-order theorem proving.We present an example that illustrates the issues accompanying the integration and describe our solution: constraining the splitting and adding an additional inference rule replacing certain clauses with AVATAR assertions by assertion-free clauses.Our experimental results indicate that the integration significantly improves the synthesis performance on some benchmarks.
The trail «Along the Yuryuzan River» — objects and routes in the UNESCO Yangan-Tau Geopark (from Yeltsovsky Riverside cliff to the mouth of the Ust-Kanda River)
Authors: Danukalova Guzel , Sokolov Yuryi , Polezhankina Polina , Osipova Evgeniya 
Published: April 2024

The valley of the Yuryuzan River from the Yeltsovsky Greben to the mouth of the Ust-Kanda River runs аcross the western slope of the Southern Urals, composed of Upper Riphean, Devonian and Carboniferous rocks, which are exposed in vertical Riverside cliffs. Carbonate rocks are associated with caves, including the famous Idrisovskaya Cave, grottoes, niches and arches. The well-known geological section Bolshaya Luka, which is described in the riverside cliff opposite the village of Verkhnyaya Luka, is a reference (stratotype) for the Bashkir Stage of the Carboniferous System.
This paper is aimed at systematizing information about the natural objects of the territory, which can be used to create organized geological and ecological trails – a kind of education of the population to focus attention on the significance of natural objects and their protection.
Desarrollo e implementación de tecnologías informáticas para procesos de pago inmediato de bajo monto a través de transferencias electrónicas
Authors: Fuquen Gonzalez Hermann Stuart , Ayala Paez Edgar Leonardo , Sánchez Rodríguez Claudia Marcela , Vargas Muñoz Lina Marcela , Rojas Barreto Milena 
Published: April 2024

The article shows the result of the innovation project developed by ACH Colombia, where a new service for immediate transfers of low amounts person to person was designed, supported by computer platforms adopting highest technological level tools available, such as Blockchain (chain of blocks), warranting high levels of reliability and security. A payment ecosystem was integrated associating the main Colombian financial entities in order to provide immediate payment services among their users, reducing the use of cash. This proposal takes advantage of the wide adoption of mobile phones and internet access to develop a system of transactional processes that facilitate the purchase and payment operations of end users. In this article, a review of the characteristics and technologies to take into account in the design of means of payment is executed, a review of cases of immediate payment systems is accomplished, the methodological implementation of this payment system is shown, and the results obtained.
Reevaluating Cosmic Origins: A Critical Analysis of Relic Radiation and Cosmometric Assumptions in Big Bang Cosmology
Authors: Traunmüller Hartmut 
Published: April 2024

This article presents a critical examination of two key aspects of Big Bang cosmology: the nature and observability of cosmic microwave background (CMB) radiation and geometric inconsistencies or “cosmometric contradictions” within established approaches to cosmology. By dissecting the conventional interpretation of the CMB as relic radiation from a primordial fireball, we uncover that the standard model’s reliance on a spatially homogeneous fluid to represent radiation and matter underestimates the propagation of radiation and leads to the conclusion that the observability of the CMB contradicts its purported origins. Treating free radiation as if it expanded with the universe while disregarding that it escapes from its source at the speed of light is termed here as the “relic radiation blunder”. Furthermore, we delve into the cosmometric contradiction, highlighting how the calculated distances in standard cosmology imply a universe that exceeds the spatial limitations of its own foundational premise. This makes it evident that standard cosmology is not a unitary theory but involves models with conflicting spatial extensions. The analysis suggests a need for a revised understanding of redshift phenomena and cosmic expansion. It advocates for a reassessment of the underpinnings of cosmology, urging the scientific community to consider alternative frameworks that reconcile these critical inconsistencies. This work challenges the inviolable core of established cosmological theory, calling for a paradigm shift to foster foundational advances in our understanding of the universe.