bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anthocyan does not suppress transformation of aryl hydrocarbon receptor induced by dioxin
Authors: Mukai Rie , Fukuda Itsuko , Nishiumi Shin , Hosokawa Keizo , Kanazawa Kazuki , Ashida Hitoshi 
Published: December 2008

AbstractDioxins cause a variety of toxic effects through transformation of a cytosolic aryl hydrocarbon receptor (AhR). We have previously demonstrated that certain natural flavones and flavonols at the dietary levels suppress AhR transformation. In this study, we investigated whether 5 anthocyanidins, 15 anthocyanins, and protocatechuic acid suppress AhR transformation in mouse hepatoma Hepa‐1c1c7 cells. All the compounds tested here at 5 μM unexpectedly failed to suppress the transformation induced by 0.1 nM TCDD, indicating that anthocyan does not have a potential to prevent dioxin toxicity.
Colosigmoid junction: Morphohistologic, morphometric, and endoscopic study with identification of colosigmoid canal with sphincter
Authors: Shafik Ali A. , Asaad Soheir , Loka Mona M. , Wahdan Mohamed , Shafik Ahmed 
Published: December 2008

AbstractTo study the anatomical structure of the colosigmoid junction, 15 cadaveric specimens were studied morphologically, another 15 histologically, and a morphometric study was done in 10 specimens. Specimens consisted of the descending colon, sigmoid colon, and the colosigmoid junction. Histologic specimens were stained with hematoxylin and eosin and Masson's trichrome stain. Morphometric studies used an image analysis system. The colosigmoid junction was investigated endoscopically in 18 healthy volunteers. A narrow segment having a mean length of 5.2 ± 1.1 cm was identified both externally and internally between the descending and sigmoid colon. We called this segment the colosigmoid canal. Mucosal folds were found crowded in the colosigmoid canal, the lower end of which formed a nipple and was surrounded by a fornix. Histologically, the colosigmoid canal mucosa showed multiple folds. Its circular muscle was thicker than that of the descending or the sigmoid colon and confirmed morphometrically. The longitudinal muscle was thicker in only 4 of 10 specimens. Both the narrowing and the mucosal crowding were verified endoscopically. The colosigmoid junction is the narrow segment between the descending and the sigmoid colon. Histologic, morphometric and endoscopic studies indicated the presence of a sphincter in the colosigmoid canal. A colosigmoid sphincter is suggested to control the passage of colonic contents from the descending colon to the colosigmoid canal as well as to prevent reflux of sigmoid contents into the descending colon. Clin. Anat. 22:243–249, 2009. © 2008 Wiley‐Liss, Inc.
Double anchoring balloon technique for recanalization of coronary chronic total occlusion by retrograde approach
Authors: Lee Nae Hee , Suh Jon , Seo Hye‐Sun 
Published: December 2008

AbstractA retrograde approach through the collateral channels is considered to improve the success rate of percutaneous coronary intervention for coronary chronic total occlusion (CTO). Various kinds of strategies and techniques are required to improve the success rate of this novel approach. We describe a case in which a CTO was successfully recanalized by the retrograde approach, using a new anchoring balloon technique (double anchoring balloon technique) which enabled the successful balloon passage through the hard CTO lesion. © 2009 Wiley‐Liss, Inc.
Herpes simplex virus lower respiratory tract infection in patients with solid tumors
Authors: Aisenberg Galbiel , Torres Harrys , Tarrand Jeffrey , Safdar Amar , Bodey Gerald , Chemaly Roy F. 
Published: December 2008

AbstractBACKGROUND:The clinical significance of herpes simplex virus (HSV) isolated in lower respiratory tract specimens (LRTS) of patients with solid tumors (ST) is unknown. In the current study, the authors attempted to determine the clinical relevance of this finding among ST patients.METHODS:The authors reviewed records of ST patients admitted to the study institution between April 2000 and April 2004 with clinical and radiologic evidence of pneumonia, and HSV identified in LRTS by culture alone or culture and cytology. Patients were categorized as having proven (HSV identified by culture and cytology from the LRTS), probable (HSV as the sole pathogen by culture alone), and possible (HSV along with copathogens identified by culture) HSV pneumonia.RESULTS:Forty‐five ST patients with either proven (6 patients), probable (25 patients), or possible (14 patients) HSV pneumonia were identified. When compared with patients with probable or possible HSV pneumonia, more patients with proven infection were on mechanical ventilation (40% vs 50% vs 100%, respectively; P = .03), and had longer length of stay in the intensive care unit (12 days vs 13 days vs 26 days, respectively; P = .05). The overall mortality rate was 22% (10 patients). Four of 25 (16%) patients who received HSV‐directed antiviral therapy died during their hospital stay versus 6 of 20 (30%) who were not treated (P = .3). None of the 6 patients with proven HSV pneumonia who were treated with acyclovir died. On univariate analysis, risk factors for mortality included underlying breast cancer, an Acute Physiology and Chronic Health Evaluation (APACHE) II score >15, admission to the intensive care unit, and use of mechanical ventilation and vasopressors (all P ≤ .05), with underlying breast cancer and APACHE II score >15 being found to be independent predictors of death by multiple logistic regression analysis (all P ≤ .05).CONCLUSIONS:Having a proven HSV pneumonia appears to be associated with high morbidity and with no increase in mortality in ST patients. This subset of patients appears to benefit from acyclovir therapy. Cancer 2009. © 2008 American Cancer Society.
Empirical estimate of fundamental frequencies and damping for Italian buildings
Authors: Gallipoli Maria Rosaria , Mucciarelli Marco , Vona Marco 
Published: December 2008

AbstractThe aim of this work is to estimate the fundamental translational frequencies and relative damping of a large number of existing buildings, performing ambient vibration measurements. The first part of the work is devoted to the comparison of the results obtained with microtremor measurements with those obtained from earthquake recordings using four different techniques: horizontal‐to‐vertical spectral ratio, standard spectral ratio, non‐parametric damping analysis (NonPaDAn) and half bandwidth method. We recorded local earthquakes on a five floors reinforced concrete building with a pair of accelerometers located on the ground and on top floor, and then collected microtremors at the same location of the accelerometers. The agreement between the results obtained with microtremors and earthquakes has encouraged extending ambient noise measurements to a large number of buildings. We analysed the data with the above‐mentioned methods to obtain the two main translational frequencies in orthogonal directions and their relative damping for 80 buildings in the urban areas of Potenza and Senigallia (Italy). The frequencies determined with different techniques are in good agreement. We do not have the same satisfactory results for the estimates of damping: the NonPaDAn provides estimates that are less dispersed and grouped around values that appear to be more realistic. Finally, we have compared the measured frequencies with other experimental results and theoretical models. Our results confirm, as reported by previous authors, that the theoretical period–height relationships overestimate the experimental data. Copyright © 2008 John Wiley & Sons, Ltd.
Changes in snowpack and snowmelt runoff for key mountain regions
Authors: Stewart Iris T. 
Published: December 2008

AbstractMountain snowpack and spring runoff are key components of surface water resources, and serve as important, regionally integrated indicators of climate variability and change. This study examines whether mountain snowpack and snowmelt have manifested a consistent hydrologic response to global climatic changes over the past several decades. Prior findings are compared to identify spatial and temporal patterns of trends in the volume, extent, and seasonality of snowpack and melt for key mountain regions. Evidence suggests that both temperature and precipitation increases to date have impacted mountain snowpacks simultaneously on the global scale; however, the nature of the impact is, among other factors, strongly dependent on geographic location, latitude, and elevation. Warmer temperatures at mid‐elevations have decreased snowpack and resulted in earlier melt in spite of precipitation increases, while they have not affected high‐elevation regions that remain well below freezing during winter. At high elevations, precipitation increases have resulted in increased snowpack. Not all local responses are consistent with the general findings, possibly because of local climatic trends, atmospheric circulation patterns, record lengths, or data quality issues. With continued warming, increasingly higher elevations are projected to experience declines in snowpack accumulation and melt that can no longer be offset by winter precipitation increases. There is a continued research need for hydroclimatic trend detection and attribution in mountains owing to the length, quality, and sparseness of available data from monitoring stations not directly impacted by human activity. Copyright © 2008 John Wiley & Sons, Ltd.
River‐ice hydrology in a shrinking cryosphere
Authors: Beltaos Spyros , Prowse Terry 
Published: December 2008

AbstractMany rivers of cold, and even temperate, regions of the globe are covered with ice for a part of the year. Projections of future climate indicate that the duration, composition and extent of ice coverage, however, will gradually change. This may have wide‐ranging consequences because ice is a critical component of cold‐regions hydrologic systems and strongly affects, for example, extreme floods, low winter flows, river transport, hydroelectric production, and numerous ecological and water‐quality characteristics. Following an overview of the processes characterizing the freezeup‐ice growth‐breakup sequence, the links of river ice to the hydrology of northern rivers are examined in detail. The rise in river stage that is caused by an ice cover is shown to be fundamental to ice‐related hydrologic impacts, such as floods caused by freezeup and breakup ice jams, low winter flows caused by water storage during freezeup and sharp waves generated by ice‐jam releases. Ice thickness and strength, both controlled by weather conditions, also play major roles. To date, the sensitivity of river‐ice regimes to changes in climatic conditions has only been partly evaluated. Most studies have focussed on ice phenology and indicate trends that are consistent with changes in air temperature, while a few recent studies have addressed the more complex questions of how climate change may alter ice thickness or the severity of extreme ice jams and floods. Foreseeable changes to river‐ice regimes, and associated hydrologic processes and impacts, are discussed in the light of current understanding. More frequent occurrence of mid‐winter breakup and associated jamming is a major effect that can be predicted with some confidence for regions where such events are presently rare or unknown. It is stressed that gaps in current knowledge preclude quantitative prediction of site‐specific changes to river‐ice regimes, and several recommendations for future research are presented. Copyright © 2008 Her Majesty the Queen in right of Canada. Published by John Wiley & Sons, Ltd.
Spectroscopy on the wing: Naturally inspired SERS substrates for biochemical analysis
Authors: Garrett Natalie L. , Vukusic Peter , Ogrin Feodor , Sirotkin Evgeny , Winlove C. Peter , Moger Julian 
Published: December 2008

AbstractWe show that naturally occurring chitinous nanostructures found on the wings of the Graphium butterfly can be used as substrates for surface‐enhanced Raman scattering when coated with a thin film of gold or silver. The substrates were found to exhibit excellent biocompatibility and sensitivity, making them ideal for protein assaying. An assay using avidin/biotin binding showed that the substrates could be used to quantify protein binding directly from changes in the surface‐enhanced Raman scattering (SERS) spectra and were sensitive over a concentration range comparable with a typical enzyme‐linked immunosorbent assays (ELISA) assay. A biomimetic version of the wing nanostructures produced using a highly reproducible, large‐scale fabrication process, yielded comparable enhancement factors and biocompatibility. The excellent biocompatibility of the wings and biomimetic substrates is unparalleled by other lithographically produced substrates, and this could pave the way for widespread application of ultrasensitive SERS‐based bioassays. (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Psychotherapy with religious and spiritual clients: an introduction
Authors: Worthington Everett L. , Aten Jamie D. 
Published: December 2008

AbstractThis invited issue of the Journal of Clinical Psychology: In Session is devoted to psychotherapy with religious and spiritual clients. After offering definitions of religion and spirituality, noting areas of potential convergence and differentiating nuances, the authors highlight the prevalence and types of spirituality among both clients and mental health professionals. They describe the historical and current context for examining approaches to psychotherapy with clients who endorse religion, experience spirituality within their religion, or define themselves as spiritual even if not religious. They then summarize the subsequent articles in this issue, which offer practical guidance for practitioners. © 2009 Wiley Periodicals, Inc. J Clin Psychol: In Session 69:1–8, 2009.
Multi‐annual dry episodes in Australian climatic variability
Authors: Hunt B. G. 
Published: December 2008

AbstractThe output from a 10 000‐year simulation with the CSIRO Mark 2 coupled global climatic model has been analysed to investigate the occurrence of multi‐year dry episodes for three selected regions of Australia, specifically, the northeast, southeast and southwest of the continent. Results are presented for dry episodes lasting for 8 or more years. An episode is defined as a time interval having consecutive negative rainfall anomalies, but not necessarily a major drought, for each year of the episode. The hydrological consequences of such an episode can persist for over a century.Typically about 30 episodes are found over the 10 000 years of the simulation for each of the three regions. There is little synchronicity between the regions in the occurrence of the dry episodes. While there is an El Nino/Southern Oscillation (ENSO) influence associated with these episodes, it is not continuous over the duration of an episode. Composites of sea surface temperature anomalies over an episode highlight the limited presence of ENSO events. The occurrence of the dry episodes for all three regions is essentially random, with multi‐centennial periods without an episode, and episodes at multi‐decadal frequency at other times. Following a discussion of possible mechanistic influences, it is concluded that stochastic forcing is responsible for the occurrence of dry episodes. This implies that there is no predictability associated with the initiation, duration or termination of individual dry episodes. This also suggests that the 2000–2007 dry episodes occurring over much of Australia may not be caused by the greenhouse effect. Such an episode has a return period of between 200 and 300 years based on the mean frequency of occurrence in the present simulation. Copyright © 2008 Royal Meteorological Society
Cholesterol esters are detected by Raman microspectroscopy in HeLa cells
Authors: van Manen Henk‐Jan , Otto Cees 
Published: December 2008

AbstractThe detection of trans‐unsaturated lipids in single HeLa cells by Raman microspectroscopy was recently reported in this journal by Onogi et al. Based on our previously published Raman microspectroscopy data of individual macrophage foam cells, a detailed comparison between our spectra and spectrum reported by Onogi et al., and the reported literature spectrum of cholesterol oleate, we here provide evidence that cholesterol esters instead of trans‐unsaturated lipids have been detected by Onogi et al. Copyright © 2008 John Wiley & Sons, Ltd.
Pseudo‐transient continuation for nonlinear transient elasticity
Authors: Gee Michael W. , Kelley C. T. , Lehoucq R. B. 
Published: December 2008

AbstractThis paper demonstrates how pseudo‐transient continuation improves the efficiency and robustness of a Newton iteration within a non‐linear transient elasticity simulation. Pseudo‐transient continuation improves efficiency by enabling larger time steps than possible with a Newton iteration. Robustness improves because pseudo‐transient continuation recovers the convergence of Newton's method when the initial iterate is not within the region of local convergence. We illustrate the benefits of pseudo‐transient continuation on a non‐linear transient simulation of a buckling cylinder, including a comparison with a line search‐based Newton iteration. Copyright © 2008 John Wiley & Sons, Ltd.
Modeling the migration of cancer cells in the bloodstream
Authors: Quek Y. L. R. , Lai T. L. , Chiam K.‐H. 
Published: December 2008

AbstractWe model the migration of cancer cells that have broken away from a tumor and are circulating in the bloodstream. Using the immersed boundary method and culling from literature the material properties of cancer cells, we simulate how cells deform as a function of the flow properties of the bloodstream as well as the adhesive properties between the cancer cells and the endothelial cells of the bloodstream. We also simulate the migration characteristics as a function of the migrating cell density. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Model reduction of nonlinear systems
Authors: Condon Marissa 
Published: December 2008

AbstractThe paper is concerned with the model reduction of nonlinear systems. Such methods are required in all branches of engineering. Often the level of detail in system models can cloud the essential behaviour and hence, methods are required to identify the behaviour of interest to the designer. In this contribution, the particular focus is on the empirical balanced truncation method of model reduction. A standard test case will illustrate the efficacies of the suggested approach. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Structure and properties of star‐shaped solution‐polymerized styrene‐butadiene rubber and its co‐coagulated rubber filled with silica/carbon black‐I: morphological structure and mechanical properties
Authors: Liu Xiao , Zhao Suhe , Yang Yong , Zhang Xingying , Wu Youping 
Published: December 2008

AbstractThe morphological structure and mechanical properties of the star‐shaped solution‐polymerized styrene‐butadiene rubber (SSBR) and organically modified nanosilica powder/star‐shaped SSBR co‐coagulated rubber (N‐SSBR) both filled with silica/carbon black (CB) were studied. The results showed that, compared with SSBR, silica powder could be mixed into N‐SSBR much more rapidly, and N‐SSBR/SiO2 nanocomposite had better filler‐dispersion and processability. N‐SSBR/SiO2/CB vulcanizates displayed higher glass‐transition temperature and lower peak value of internal friction loss than SSBR/SiO2/CB vulcanizates. In the N‐SSBR/SiO2/CB vulcanizates, filler was dispersed in nano‐scale resulting in good mechanical properties. Composites filled with silica/CB doped filler exhibited more excellent mechanical properties than those filled with a single filler because of the better filler‐dispersion and stronger interfacial interaction with macromolecular chains. N‐SSBR/SiO2/CB vulcanizates exhibited preferable performance in abrasion resistance and higher bound rubber content as the blending ratio of silica to CB was 20:30. Copyright © 2008 John Wiley & Sons, Ltd.
Potential chemotherapy side effects: What do oncologists tell parents?
Authors: Ramirez Lisa Ysela , Huestis Samantha E. , Yap Tsiao Yi , Zyzanski Stephen , Drotar Dennis , Kodish Eric 
Published: December 2008

AbstractBackgroundIn order to determine the number of short‐term side effects and late effects discussed during an informed consent conference (ICC) after the diagnosis of acute leukemia, we observed the occurrence(s) and the ratio between short‐term side effects versus late effects during an ICC.ProcedureICC(s) of childhood leukemia trials were audio‐taped at six different study sites. The side effects mentioned during each of these ICC(s) were coded and analyzed.ResultsOne hundred forty cases were reviewed, from which we coded a total of 3,173 acute side effects and 242 late effects. The mean total side effects mentioned during each ICC was 24 (range 5–47). The number of late effects coded were significantly less than acute side effects. We also found that the duration of ICC(s) was positively correlated with the number of side effects mentioned. In addition, the frequency of total side effects mentioned was independent of patient or parent demographic factors.ConclusionsOur results show that acute side effects are often mentioned but the discussion of late effects is much less frequent in the initial ICC(s). Careful consideration regarding the ratio of acute and late effects that are communicated to parents in the context of the ICC may facilitate parental understanding of clinically relevant side effects. Pediatr Blood Cancer 2009;52:497–502. © 2008 Wiley‐Liss, Inc.
Early detection of adrenocortical carcinoma in a child with Li–Fraumeni syndrome
Authors: Lin Ming‐Tsan , Shieh Jeng‐Jer , Chang Julia Hui‐Mei , Chang Shih‐Wen , Chen Tse‐Ching , Hsu Wen‐Hu 
Published: December 2008

AbstractWe report an early detection of cancer in a child with Li–Fraumeni syndrome. The proband was a 3‐year‐old male with a primitive mesenchymal tumor. Genetic analysis showed a germline TP53 mutation in codon 220 exon 6, which changed TAT → TGT and resulted in a tyrosine‐to‐cysteine amino acid substitution (Tyr220Cys). The younger sister at risk was followed, and an asymptomatic adrenal cortical carcinoma was detected 3 years later. The report highlights the importance of genetic counseling and provides an example of early detection of cancers in childhood LFS carriers. Pediatr Blood Cancer 2009;52:541–544. © 2008 Wiley‐Liss, Inc.
Bevacizumab treatment in multifocal lymphangioendotheliomatosis with thrombocytopenia
Authors: Kline Ronald M. , Buck Laura Marcu 
Published: December 2008

AbstractMultifocal lymphangioendotheliomatosis with thrombocytopenia (MLT) is a rare disorder characterized by a proliferation of cutaneous and gastrointestinal (GI) lesions that have characteristics of both lymphatic and vascular lesions. Thrombocytopenia is associated with this syndrome and is thought to represent platelet destruction within the lesions. The natural history is one of multiple, life‐threatening episodes of GI bleeding. We report the successful use of bevacizumab in this disease, an antibody to the vascular endothelial growth factor. Pediatr Blood Cancer 2009;52:534–536. © 2008 Wiley‐Liss, Inc.