bluuebunny/crossref_metadata_2025_split huggingface dataset:
New Developments in Simulated Moving Bed Chromatography
Authors: Seidel‐Morgenstern A. , Keßler L. C. , Kaspereit M. 
Published: May 2008

AbstractChromatographic separation processes are widely used to isolate and purify value added products. Most frequently, such separation processes are performed exploiting the principles of injecting samples of the feed mixture in a repetitive periodic manner and collecting the target products batchwise. In the early 1960s, an alternative operation principle based on using several columns connected in series and exploiting a continuous countercurrent movement between the mobile and stationary phases initiated significant improvements in performing specific separation processes in the petrochemical and sugar industries. In the last decade, the so‐called simulated moving bed (SMB) chromatography has rapidly entered the pharmaceutical industry. In particular enantioseparations using chiral stationary phases have become a strong driving force to develop more sophisticated concepts of continuous chromatography. Currently, the growing interest in efficient methods for the downstream processing of biomolecules enhances interest in SMB processes. This paper gives a brief overview of the new suggestions and trends.
Designing Robust Preparative Purification Processes with High Performance
Authors: Degerman M. , Jakobsson N. , Nilsson B. 
Published: May 2008

AbstractIn the production of pharmaceutical drugs, a large part of the production costs stem from the downstream processing and the chromatographic purifications required. In order to reduce purification costs the process performance must be increased, which means that the processes need to be less robust since robustness comes with the price of lower process performance, and thus, higher production costs. It is difficult to find a good estimate of the robustness of a process experimentally, and therefore, the pharmaceutical industry has been forced to design processes to be very robust. This work presents a model‐based method for optimizing purification processes both with regard to performance and robustness. A model of chromatographic processes and methods of calibration are presented. The model is then used to determine the operating conditions with highest performance when robustness is not taken into account. With this as a starting point, the process is then optimized for higher robustness and lower probability of batch failure. The purification of Immunoglobulin G through ion exchange chromatography is used to demonstrate the method.
Downstream Processing: From Egg to Cell Culture‐Derived Influenza Virus Particles
Authors: Wolff M. W. , Reichl U. 
Published: May 2008

AbstractThe establishment of cell culture‐derived vaccine production requires the development of appropriate downstream processes. Until today, many of the downstream methods applied originate from egg‐derived production processes. These methods have often been slightly modified in order to account for the new demands. However, efforts are currently underway to optimize these processes focusing, for example, on ion exchange or affinity based membrane adsorption chromatography. This review covers the main aspects relevant for the downstream processing of egg and mammalian cell culture‐derived whole influenza viruses.
High Throughput Screening for the Design and Optimization of Chromatographic Processes – Miniaturization, Automation and Parallelization of Breakthrough and Elution Studies
Authors: Wiendahl M. , Schulze Wierling P. , Nielsen J. , Fomsgaard Christensen D. , Krarup J. , Staby A. , Hubbuch J. 
Published: May 2008

AbstractThis study evaluates the applicability of the liquid handling workstation Tecan Evo Freedom 200 and 200 μL Media Scout RoboColumns to dynamic chromatographic operations such as frontal analysis (breakthrough) and elution experiments in a high throughput screening mode. Breakthrough experiments were conducted using BSA as a model protein and the stationary phases Poros 50 D, Q Ceramic HyperD and DEAE Sepharose FF. The obtained dynamic capacities at 10 and 50 % breakthrough matched well with reference data. Elution experiments were performed applying three protein mixtures: a) lipolase and BSA, b) human growth hormone and a process‐related impurity, and c) an insulin analogue and a process‐related impurity. The resins used resembled a variety of different ion exchange resins. In all cases, the resulting elution curves matched well with reference measurements performed on an ÄKTA explorer system at 1 mL or 2 mL scale.
GRAM satisfies Kruskal's condition
Authors: Faber Nicolaas (Klaas) M. 
Published: May 2008

AbstractIt is well known that least‐squares (LS) methods uniquely identify the parameters of the CANDECOMP/PARAFAC model if Kruskal's condition is satisfied. By contrast, a stricter sufficient condition applies to eigenvalue‐based methods like the generalized rank annihilation method (GRAM). This discrepancy suggests that LS methods can solve problems for which GRAM must fail. However, GRAM has been specifically introduced for the special case of a three‐way array with two frontal slices only (i.e. K = 2). Here, it is shown that the two conditions are equivalent for this special case. Copyright © 2008 John Wiley & Sons, Ltd.
On a new semi‐empirical electrotopological index for QSRR models
Authors: Souza Érica Silva , Kuhnen Carlos Alberto , Junkes Berenice da Silva , Yunes Rosendo Augusto , Heinzen Vilma Edite Fonseca 
Published: May 2008

AbstractA new semi‐empirical electrotopological index, ISET, for quantitative structure–retention relationships (QSRR) models was developed based on the refinement of the previously published semi‐empirical topological index, IET. We demonstrate that the values of Ci fragments that were firstly attributed from the experimental chromatographic retention and theoretical deductions have an excellent relationship with the net atomic charge of the carbon atoms. Thus, the values attributed to the vertices in the hydrogen‐suppressed graph of carbon atoms (Ci) are calculated from the correlation of the net atomic charge in each carbon atom, which is obtained from quantum chemical semi‐empirical calculations, and the Ci fragments for primary, secondary, tertiary and quaternary carbon atoms (1.0, 0.9, 0.8 and 0.7, respectively) obtained from the experimental values. This shows that IET encoded this quantum physical reality and that it is possible to calculate a new ISET (the semi‐empirical electrotopological index) through the net atomic charge values obtained from a Mulliken population analysis using the semi‐empirical AM1 method and their correlation with the values attributed to the different types of carbon atoms. This demonstrates that the ISET encodes information on the charge distribution of the solute on which dispersive and electrostatic interactions between the solute (alkanes and alkenes) and the stationary phase strongly depend. Thus, this new method can be considered as an initial step towards forthcoming QSRR/QSAR studies. Copyright © 2008 John Wiley & Sons, Ltd.
A new linear method for analyzing four‐way multiblock tables: STATIS‐4
Authors: Sabatier Robert , Vivien Myrtille 
Published: May 2008

AbstractA new four‐way multiblock method is proposed to study the links between more than two sets of data tables (several multiblocks) measured on the same observations. This method, called STATIS‐4, generalizes the STATIS method to more than one set of matrices. In its first step, STATIS‐4 is searching for one consensus for each multiblock and a global consensus summarizing all the previous ones as good as possible. Some graphical representations can be made to visualize the proximities between the tables within a multiblock and to visualize those between all the multiblocks. Moreover, plots of the observations for each table, each multiblock and global observations can be made. The theory of STATIS‐4 and the algorithm used to obtain the optimal solutions are presented. Moreover, a real sensory dataset is studied with STATIS‐4. Copyright © 2008 John Wiley & Sons, Ltd.
Erratum: ST‐PLS: a multi‐directional nearest shrunken centroid type classifier via PLS
Authors: Sæbø Solve , Almøy Trygve , Aarøe Jørgen , Aastveit Are H. 
Published: May 2008

AbstractJ. Chemometrics 22(1): 54–62. DOI: 10.1002/cem.1101It has come to our attention that errors arose in the printing of this article.The article title and the authors' names were printed incorrectly and should appear as above. Throughout this article, the characters ‘fi’ in, for example, the word ‘classifiers’ were not present in the printed version of the paper.We apologise for any inconvenience caused.
ChemInform Abstract: Theoretical Study of the Structural and Electronic Properties of SimGen and SimGen‐ (s = m + n ≤ 7) Clusters.
Authors: Bing Dan , Nguyen Quoc Chinh , Fan Xiao‐feng , Kuo Jer‐Lai 
Published: May 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Structural Paradigms in Macropolyhedral Boranes.
Authors: Kiani Farooq Ahmad , Hofmann Matthias 
Published: May 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Crystal Chemistry in the Ag2O—Nb2O5 System — AgNb3O8 Structure Determination.
Authors: Rozier Patrick , Szajwaj Olivier 
Published: May 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Crystal Chemistry of Co‐Doped Zn7Sb2O12.
Authors: Harrington Richard , Miles Gabrielle C. , West Anthony R. 
Published: May 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Iron‐Based Layered Superconductor La[O1‐xFx]FeAs (x = 0.05—0.12) with Tc = 26 K.
Authors: Kamihara Yoichi , Watanabe Takumi , Hirano Masahiro , Hosono Hideo 
Published: May 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Superconductivity in Hydrogen Dominant Materials: Silane.
Authors: Eremets M. I. , Trojan I. A. , Medvedev S. A. , Tse J. S. , Yao Y. 
Published: May 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Phase Stability and Ionic Conductivity in Substituted La2W2O9.
Authors: Marrero‐Lopez D. , Pena‐Martinez J. , Ruiz‐Morales J. C. , Nunez P. 
Published: May 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The CdSe—Ga2Se3—PbSe System.
Authors: Sosovska S. M. , Olekseyuk I. D. , Parasyuk O. V. 
Published: May 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Low‐Temperature Route for the Synthesis of Nanocrystalline LaB6.
Authors: Zhang Maofeng , Yuan Liang , Wang Xiaoqing , Fan Hai , Wang Xuyang , Wu Xueying , Wang Haizhen , Qian Yitai 
Published: May 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Two New Hydrogen Bond‐Supported Supramolecular Compounds Assembly from Arsenic Vanadates and [M(H2O)6]2+ Cations (M: Co, Ni).
Authors: Cui Xiao‐Bing , Li Ke‐Chang , Ye Ling , Chen Yan , Xu Ji‐Qing , Duan Wei‐Jie , Yu Hai‐Hui , Yi Zhi‐Hui , Cui Ji‐Wen 
Published: May 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Ti‐Mediated Direct and Highly Stereoselective Mannich Reactions Between Esters and Oxime Ethers.
Authors: Funatomi Takashi , Nakazawa Shogo , Matsumoto Kunshi , Nagase Ryohei , Tanabe Yoo 
Published: May 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Novel Chiral Porous Metal—Organic Framework: Asymmetric Ring Opening Reaction of Epoxide with Amine in the Chiral Open Space.
Authors: Tanaka Koichi , Oda Shinji , Shiro Motoo 
Published: May 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Cationic Chiral Dirhodium Carboxamidates Are Activated for Lewis Acid Catalysis.
Authors: Wang Yuanhua , Wolf Joffrey , Zavalij Peter , Doyle Michael P. 
Published: May 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Asymmetric Organocatalyzed [1,3]‐Sigmatropic Rearrangements.
Authors: Kobbelgaard Sara , Brandes Sebastian , Joergensen Karl Anker 
Published: May 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Diels—Alder Cycloadditions by Microwave‐Assisted, Continuous Flow Organic Synthesis (MACOS): The Role of Metal Films in the Flow Tube.
Authors: Shore Gjergji , Organ Michael G. 
Published: May 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Practical Route to Pyrazines and Quinoxalines, and an Unusual Synthesis of Benzimidazoles.
Authors: Mougin Catherine , Sancon Julien , Zard Samir Z. 
Published: May 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of New 1,3,8‐Trisubstituted Purine‐2,6‐diones and 1,3,6‐Trisubstituted Thiazolo[2,3‐f]purine‐2,4‐diones.
Authors: Hayallah Alaa M. , Famulok Michael 
Published: May 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Hydrazine Sulfate: A Cheap and Efficient Catalyst for the Regioselective Ring‐Opening of Epoxides. A Metal‐Free Procedure for the Preparation of β‐Alkoxy Alcohols.
Authors: Leitao Alcino J. L. , Salvador Jorge A. R. , Pinto Rui M. A. , Melo M. Luisa Sa 
Published: May 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Catalytic Dehydrogenation of o‐Alkylated or o‐Alkoxylated Iodoarenes with Concomitant Hydrogenolysis.
Authors: Motti Elena , Catellani Marta 
Published: May 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A First Homogeneous Gold(III)‐Catalyzed Epoxidation of Aromatic Alkenes.
Authors: Li Xiao‐Qiang , Li Chen , Song Fan‐Bo , Zhang Chi 
Published: May 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Supramolecular PhanePhos‐Analogous Ligands Through Hydrogen‐Bonding for Asymmetric Hydrogenation.
Authors: Laungani Andy Ch. , Breit Bernhard 
Published: May 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: An Alternative Method for the Regio‐ and Stereoselective Bromination of Alkenes, Alkynes, Toluene Derivatives and Ketones Using a Bromide/Bromate Couple.
Authors: Adimurthy Subbarayappa , Ghosh Sudip , Patoliya Paresh U. , Ramachandraiah Gadde , Agrawal Manoj , Gandhi Mahesh R. , Upadhyay Sumesh C. , Ghosh Pushpito K. , Ranu Brindaban C. 
Published: May 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Trans‐Spanned Palladium Catalyst for Mild and Efficient Amination of Aryl Halides with Benzophenone Imine.
Authors: Grossman Olga , Rueck‐Braun Karola , Gelman Dmitri 
Published: May 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Gold(III)‐Catalyzed Cyanosilylation of Ketones and Aldehydes.
Authors: Cho Woo Kyung , Kang Sung Min , Medda Amiya K. , Lee Jungkyu K. , Choi Insung S. , Lee Hee‐Seung 
Published: May 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: High Yielding Alkylations of Unactivated sp3 and sp2 Centers with Alkyl‐9‐BBN Reagents Using an NHC‐Based Catalyst: Pd‐PEPPSI‐IPr.
Authors: Valente Cory , Baglione Sylvia , Candito David , O'Brien Christopher J. , Organ Michael G. 
Published: May 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Michael Reactions of Titanium Enolates of Glycolic Acid Derivatives with the Weinreb and Morpholine Amides of Acrylic Acid.
Authors: Olivella Anna , Rodriguez‐Escrich Carles , Urpi Felix , Vilarrasa Jaume 
Published: May 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Palladium/Phosphite‐Catalyzed 1,4‐Addition of Arylboronic Acids to Acrylic Acid Derivatives.
Authors: Horiguchi Hakaru , Tsurugi Hayato , Satoh Tetsuya , Miura Masahiro 
Published: May 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Efficient 1,2‐Addition of Aryl‐ and Alkenylboronic Acids to Aldehydes Catalyzed by the Palladium/Thioether—Imidazolinium Chloride System.
Authors: Kuriyama Masami , Shimazawa Rumiko , Shirai Ryuichi 
Published: May 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Iron‐Catalyzed Green Synthesis of Carboxylic Esters by the Intermolecular Addition of Carboxylic Acids to Alkenes.
Authors: Choi Jun‐Chul , Kohno Kazufumi , Masuda Daisuke , Yasuda Hiroyuki , Sakakura Toshiyasu 
Published: May 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.