bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adapting agroforestry to upland farming systems: narratives from smallholder farmers in Northwest Vietnam
Authors: Do Hoa , Whitney Cory , La Nguyen , Storm Hugo , Luedeling Eike 
Published: March 2024

AbstractFruit tree–based agroforestry has been promoted as an alternative farming practice in upland Northwest Vietnam to replace monocultures of staple crops. Although many studies have focused on evaluating the performance of agroforestry systems at the plot level, research on how farmers perceive and evaluate agroforestry considering whole-farm contexts is limited. We explored the perceptions and reasoned management decisions of agroforestry farmers to uncover challenges that hinder the wider use of agroforestry, and we assessed farmers’ strategies for effective management of adoption challenges. We combined the Q methodology and the systems thinking approach. With the Q methodology, we explored prevalent discourses among the members of the farming community on the impact of agroforestry. Systems thinking elucidated a system-wide understanding of farmers’ adaptive decision-making processes. By combining the two approaches, we uncovered the dynamics that shape farmers’ perceptions and the rationale behind their management of the adoption process. Through the Q method, we identified three distinct discourses among participants. Two of these discourses are in favor of agroforestry, highlighting its beneficial impacts on livelihoods and the environment, e.g., through diversification of household income and through soil erosion control. We also generated a collective development pathway outlining how farmers navigated and adapted agroforestry practices to overcome adoption challenges through a whole-system approach to farm resource management. We identified structural barriers, such as unstable farm-gate prices, that may need high-level interventions. Our study adds a new dimension to the assessment of agroforestry through farmers’ perspectives and contributes to the existing body of research on knowledge systems in agroforestry. Considering farmers’ views and their ways of reasoning during innovation processes may allow tailoring appropriate innovations by accounting for unique farm situations and local farming systems. Such locally generated knowledge will have relevance for real-world contexts and therefore be useful for guiding actions.
The effect of lacosamide on calcitonin gene-related peptide serum level in episodic migraine patients: a randomized, controlled trial
Authors: Elgamal Shimaa , Ahmed Sherihan Rezk , Nahas Mohamed M. , Hendawy Shimaa R. , Elshafei Osama , Zeinhom Mohamed G. 
Published: March 2024

Abstract
Background
Migraine affects 11–15% of people worldwide, and the calcitonin gene-related peptide (CGRP) is released during the migraine attack, producing pulsating pain of migraine. Also, lacosamide reacts with collapsin-response mediator protein 2, preventing its phosphorylation and leading to the inhibition of CGRP release in the trigeminal system.

Objective
The primary outcome was the difference in the serum level of CGRP-LI after three months of treatment with either lacosamide and ibuprofen or ibuprofen alone in episodic migraine patients. The secondary outcomes were assessing safety and efficacy of lacosamide in episodic migraine patients.

Methods
We conducted an open-label randomized controlled trial on episodic migraine patients aged 10–55 years diagnosed according to (ICHD-3) in Kafr El-Sheikh University Hospital, Egypt. We assessed serum levels of CGRP-LI before and three months after treatment in our two groups, the lacosamide, and the control groups. We also assessed the side effects of treatment in each group, the percentage of patients who achieved ≥ 50% reduction in the migraine monthly days (MMD) frequency and the percentage of patients who achieved pain freedom within 2 h in ≥ 4 of 5 attacks in each group.

Results
200 episodic migraine patients completed the study. There was a statistically significantly higher reduction in the serum CGRP-LI level in the lacosamide group compared with the control group. In addition, lacosamide was well tolerated by patients. Also, the lacosamide group had statistically significant higher percentage of patients who achieved ≥ 50% reduction in the migraine monthly days (MMD) frequency and pain freedom within two hours in ≥ 4 of 5 attacks with P-values 0.002, 0.02 respectively.

Conclusion
The daily use of lacosamide 50 mg Bid for three months in episodic migraine patients was associated with a significant reduction in serum CGRP-LI, better clinical outcomes regarding frequency and duration of migraine attacks, and was well tolerated by patients. These results were derived from an open-label pilot study that needed to be thoroughly investigated by a large-scale, randomized, double-blinded, placebo-controlled study.
Trial registration: We registered our trial on ClinicalTrials.gov, named after "The Lacosamide's Effect on Calcitonin Gene-related Peptide in Migraine Patients," and with a clinical trial number (NCT05632133)—August 8, 2023.
High-Throughput Extraction of Phase–Property Relationships from Literature Using Natural Language Processing and Large Language Models
Authors: Montanelli Luca , Venugopal Vineeth , Olivetti Elsa A. , Latypov Marat I. 
Published: March 2024

AbstractConsolidating published research on aluminum alloys into insights about microstructure–property relationships can simplify and reduce the costs involved in alloy design. One critical design consideration for many heat-treatable alloys deriving superior properties from precipitation are phases as key microstructure constituents because they can have a decisive impact on the engineering properties of alloys. Here, we present a computational framework for high-throughput extraction of phases and their impact on properties from scientific papers. Our framework includes transformer-based and large language models to identify sentences with phase-property information in papers, recognize phase and property entities, and extract phase-property relationships and their “sentiment.” We demonstrate the application of our framework on aluminum alloys, for which we build a database of 7,675 phase–property relationships extracted from a corpus of almost 5000 full-text papers. We comment on the extracted relationships based on common metallurgical knowledge.
The ectopic mandibular canines can start tooth formation in three different locations: a case series study based on single orthopantomograms from 47 individuals
Authors: Svanholt P. , Svanholt M. , Thomsen J. , Kjær I. 
Published: March 2024

Abstract
Introduction
A former study on orthopantomograms from young children with abnormal dental development (not canine ectopia) demonstrated that the tooth bud of the mandibular canine, compared to a stable longitudinal canine axis, could be located normally, anteriorly or posteriorly, with close relation to the first premolar.

Aim
The aim of the present study is to analyse on orthopantomograms if the canine axis can demonstrate where the ectopic mandibular canine started tooth formation.

Materials
The material consists of orthopantomograms with ectopic mandibular canines and presence of primary mandibular canines from 47 cases (29 cases 9–21 years old and 18 cases with unknown ages). The primary canines demonstrated from minor apical resorption to more severe apical resorption.

Methods
Based on canine maturity, location of the canine axes and the interrelationships between the roots of the permanent canine and first premolar, the location from where the canine started tooth formation was determined. Canine maturity. Maturity stage below half root length and maturity stage above half root length revealed that 11 ectopic canines had less than half root length and 36 cases more than half root length. Canine axes. The canine axis, through the length of the primary canines Ax, is inserted on drawings of the orthopantomograms using the tracing programme Inkscape®. Interrelationship between roots. By visual inspection, the distance between the canine and first premolar was designated close distance, normal distance and extended distance.

Results
The results are divided into 3 groups. Group 1: The initial site of the permanent ectopic canine is located within the canine axis (6 cases). Group 2: The initial site of the permanent ectopic canine is located posterior to the canine axis (36 cases). Group 3: The initial site of the permanent ectopic canine is located anterior to the canine axis (5 cases).

Conclusion
The study explained that the canine axis could divide cases of ectopic canines into three groups according to the location from where tooth formation starts. For getting closer to the pattern of the ectopic canine eruption, it is necessary to analyse series of orthopantomograms taken from the same individual over several years.
Time to Change How We Measure Quality of Life and Well-Being in Autism: A Systematic Review
Authors: Simpson Kate , Paynter Jessica , Westerveld Marleen , van der Meer Larah , Patrick Lee , Hogg Gabrielle , Heussler Helen , Heyworth Melanie , Gable Alison , Chandran Hem Sid , Bowen Rachael , Adams Dawn 
Published: March 2024

AbstractThis review examines methods used to report on the QoL and/or well-being of autistic people. A search of four databases (June 2023) identified 256 studies that reported on the Qol and/or well-being of at least one autistic person. The quality of studies varied. Results were synthesised on who reported, who was reported on, how information was obtained including accommodations and community involvement. One-third used proxy informants, over 80% used generic measures of QoL and/or well-being, autistic people with intellectual impairment and communication disorders were underrepresented, one quarter included accommodations, and few studies included community involvement. Despite the growing research on QoL and well-being of autistic people, more accessible and inclusive research is required to understand autistic people’s experience.
Evaluation of pituitary function and metabolic parameters in patients with traumatic maxillofacial fractures
Authors: Daloglu O. O. , Unal M. C. , Kemaloglu C. A. , Bolatturk O. F. , Ozyazgan I. , Tanriverdi F. , Coruh A. , Kelestimur F. 
Published: March 2024

Abstract
Purpose
This study was designed to assess the pituitary functions of patients with traumatic maxillofacial fractures and compare the results with healthy controls.

Methods
Thirty patients (mean age, 38.14 ± 14.15 years; twenty-six male, four female) with a traumatic maxillofacial fracture at least 12 months ago (mean 27.5 ± 6.5 months) and thirty healthy controls (mean age, 42.77 ± 11.36 years; twenty-five male, five female) were included. None of the patients were unconscious following head trauma, and none required hospitalization in intensive care. Basal pituitary hormone levels of the patients were evaluated. All patients and controls had a glucagon stimulation test and an ACTH stimulation test to evaluate the hypothalamic–pituitary–adrenal axis and the GH–IGF-1 axis.

Results
Five of thirty patients (16.6%) had isolated growth hormone (GH) deficiency based on a glucagon stimulation test (GST). The mean peak GH level after GST in patients with hypopituitarism (0.54 ng/ml) was significantly lower than those without hypopituitarism (7.01 ng/ml) and healthy controls (11.70 ng/ml) (P < 0.001). No anterior pituitary hormone deficiency was found in the patients, except for GH.

Conclusion
Our study is the first to evaluate the presence of hypopituitarism in patients with traumatic maxillofacial fractures. Preliminary findings suggest that hypopituitarism and GH deficiency pose significant risks to these patients, particularly during the chronic phase of their trauma. However, these findings need to be validated in larger scale prospective studies with more patients.
Quantum K-theory of incidence varieties
Authors: Xu Weihong 
Published: March 2024

AbstractWe prove a conjecture of Buch and Mihalcea in the case of the incidence variety $$X=\textrm{Fl}\hspace{0.55542pt}(1,n-1;n)$$

X
=
Fl

(
1
,
n
-
1
;
n
)

and determine the structure of its (T-equivariant) quantum K-theory ring. Our results are an interplay between geometry and combinatorics. The geometric side concerns Gromov–Witten varieties of 3-pointed genus 0 stable maps to X with markings sent to Schubert varieties, while on the combinatorial side are formulas for the (equivariant) quantum K-theory ring of X. We prove that the Gromov–Witten variety is rationally connected when one of the defining Schubert varieties is a divisor and another is a point. This implies that the (equivariant) K-theoretic Gromov–Witten invariants defined by two Schubert classes and a Schubert divisor class can be computed in the ordinary (equivariant) K-theory ring of X. We derive a positive Chevalley formula for the equivariant quantum K-theory ring of X and a positive closed formula for Littlewood–Richardson coefficients in the non-equivariant quantum K-theory ring of X. The Littlewood–Richardson rule in turn implies that non-empty Gromov–Witten varieties given by Schubert varieties in general position have arithmetic genus 0.
Learning to cooperate in the shadow of the law
Authors: Galbiati Roberto , Henry Emeric , Jacquemet Nicolas 
Published: March 2024

AbstractFormal enforcement punishing defectors can sustain cooperation by changing incentives. In this paper, we introduce a second effect of enforcement: it can also affect the capacity to learn about the group's cooperativeness. Indeed, in contexts with strong enforcement, it is difficult to tell apart those who cooperate because of the threat of fines from those who are intrinsically cooperative types. Whenever a group is intrinsically cooperative, enforcement will thus have a negative dynamic effect on cooperation because it slows down learning about prevalent values in the group that would occur under a weaker enforcement. We provide theoretical and experimental evidence in support of this mechanism. Using a lab experiment with independent interactions and random rematching, we observe that, in early interactions, having faced an environment with fines in the past decreases current cooperation. We further show that this results from the interaction between enforcement and learning: the effect of having met cooperative partners has a stronger effect on current cooperation when this happened in an environment with no enforcement. Replacing one signal of deviation without fine by a signal of cooperation without fine in a player's history increases current cooperation by 10%; while replacing it by a signal of cooperation with fine increases current cooperation by only 5%.
Evaluation and formulation of Spirulina platensis proteins for potential applications in hair care products
Authors: Elkady Omar A. , Mannaa Islam M. , El Bishbishy Mahitab H. 
Published: March 2024

AbstractSpirulina platensis, a blue-green algae belonging to family Phormidiaceae, is well-known for its unique nutritional profile and high protein content. This study aims to isolate its proteins, formulate them into a cream and evaluate its potential as a hair treatment. S. platensis were collected from Nuweiba, Egypt and its protein was extracted, analyzed and used to prepare a cream. The cream was applied on natural hair strands compared to a control cream containing no protein. Both hair strands groups were observed via Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), Atomic Force Microscopy (AFM) and evaluated by Fourier-transform infrared spectroscopy (FTIR), Raman spectroscopy, as well as, thermal analysis tests including thermogravimetric analysis (TGA) and Differential Scanning Calorimetry (DSC). The SEM images of the test group showed more intact cuticle with the absence of cracks and holes, also, the TEM images showed stronger non-porous cuticle compared to the control group. The AFM images of the test group was smoother with lower roughness average and step height compared to the control group. On the other hand, the raman spectra showed different band intensities for disulfide bonds and C-S bonds as well as increased number of b sheet conformations in the test group which is responsible for the smoothing effect. The thermal analysis tests revealed a clear difference between both groups as an indication of improved keratin structure on the test group. S. platensis proteins could be introduced as a potential candidate for hair care products.
Metabolomics and gut metagenomics profile of the healthy adults on consumption of whey protein supplemented with enzymes-probiotics blend
Authors: Rathi Abhijit , Gaonkar Tejal , Dhar Debojyoti , Kallapura Gopalakrishna , Jadhav Swati 
Published: March 2024

AbstractIn this randomized, crossover, pilot clinical study, we aimed to evaluate the effect of supplementation of enzymes-probiotics blend with whey protein on the amino acid absorption and gut microbiota. Healthy subjects were supplemented with the whey protein and test i.e. Pepzyme Pro (enzymes-probiotics blend) or placebo i.e. maltodextrin for 15 days with the washout period of 30 days. Blood samples were analyzed for plasma free amino acids, insulin, and CRP. Additionally, urine nitrogen, fecal nitrogen, and gut microbiota were evaluated. On day 15, the test arm showed upward trend in rate of amino acid absorption than placebo arm within 30 min of post ingestion of protein. Moreover, rate of absorption of few essential and branched chain amino acids were significantly higher (methionine (p = 0.049), leucine (p = 0.014), isoleucine (p = 0.053)) in the test arm on day 15. Total branched chain amino acids absorption were found to be significantly higher (p ≤ 0.05) in the test arm than the placebo arm within 30 min of post ingestion on day 15. Uptrend in total amino acid absorption and Cmax, and downtrend in Tmax was observed on day 15 in the test arm. The CRP, fecal nitrogen, and urine nitrogen remained unaltered after supplementation. Microbiota profiling showed significant change in abundance of species of genus Bacteroides and phylum Bacteroidetes. Overall, metagenomics and metabolomics based assessments demonstrated that the consumption of Pepzyme Pro with whey protein could potentially improve protein digestion, amino acid absorption, and modulate gut microbiota.Clinical trial registration The clinical trial registry of India CTRI/2021/09/036169 [Registered on: 02/09/2021]
Traits impacting water crisis management
Authors: Yasmeen Kausar , Yasmin Kashifa , Adnan Muhammad 
Published: March 2024

AbstractWater scarcity and its geopolitical implications have been a cornerstone of scholarly discourse. However, literature often overlooks the nuanced relationship between human traits and water management. Addressing this oversight, this study synthesized data from 149 articles (1991–2023), revealing a substantial connection between human actions and water management dynamics. From this data, a unique comprehensive framework was developed, focusing on the intricate interplay of human behaviors, leadership dynamics, economic factors, and technological advancements in water management. Unlike previous works, this framework holistically integrates these components, offering a fresh lens through which to understand the human-centric factors underpinning global water scarcity. This study underscores the framework’s vital role in guiding sustainable water management and strategy, making it an indispensable tool for stakeholders, from policymakers to environmentalists. In essence, this research not only bridges a knowledge gap but also serves as a beacon for addressing pressing water scarcity challenges in today’s world.
Culturomics: A critical approach in studying the roles of human and animal microbiota
Authors: Howe Samantha , Liu Ziyu , Zuo Bin , Zhao Jiangchao 
Published: March 2024

Abstract
The rise of sequencing technologies has greatly contributed to our knowledge of the microbiota and its role in animal health and production. However, many members of the microbiota have historically been considered “unculturable.” Culturomics can be utilized to bring these fastidious microbes into cultivation and can be used in conjunction with culture-independent methods to study the microbiota in a more comprehensive manner. This review paper details culturomics’ role in revolutionizing human, swine, and bovine microbiota research and how its use has greatly increased the bacterial repertoire. Additionally, it describes how culturomics can be applied to develop microbiota-derived therapeutics, such as next-generation probiotics, and to study the role of the microbiota. Finally, this review provides potential methods and considerations for designing future culturomics studies.
Labor Rights and Dispute System Design: Assessing the Legal Legacy of the 2022 Qatar World Cup
Authors: Calo Zachary R. 
Published: March 2024

AbstractThe aim of this paper is not to relitigate Qatar’s human rights record but to assess the effectiveness of its labor reforms: the principal concern is dispute resolution and enforceability. While Qatar instituted a broad suite of labor law reforms in the years preceding the World Cup, questions remain about whether they have improved access to justice for migrant workers. More attention needs to be given to the dispute settlement system established by Law No. 13 of 2017 to assess if new legal norms translate into enforceable rights. It is argued that the labor dispute system has largely failed by not taking into account the circumstances that define the employer-employee relationship in Qatar, especially the stark imbalance in power. While reforms might endure at the level of formal law, the dispute system will fail to deliver genuine justice to workers unless it is refashioned.
RETREATMENT OF BONE MATERIAL IN THE GLIWICE RADIOCARBON LABORATORY USING ULTRAFILTRATION
Authors: Pawełczyk Fatima , Niedziałkowska Magdalena , Pawełczyk Sławomira , Piotrowska Natalia , Sykut Maciej 
Published: March 2024

ABSTRACTPreparation of bones for radiocarbon (14C) dating is still quite a challenge for researchers. The methods are being tested and improved, to increase reliability of dating results and to verify the previous ones. In this work, a set of gelatine samples, extracted from Cervus elaphus and Cervus canadensis bones from various sites in Europe and a set of human bones from archaeological sites in Poland were subjected to retreatment using ultrafiltration in Gliwice Radiocarbon Laboratory. The tested samples represent a wide range of ages, from older than 40,000 14C years BP to modern. The prepared material was subjected to the measurement of C/N atomic ratios and 14C dating using the accelerator mass spectrometry (AMS) technique. Also, the stable isotopes (δ13C and δ15N) values were determined. In a few cases ultrafiltration allows to improve gelatine quality for long-stored samples, by increasing the %C and %N as well as decreasing C/Nat ratios. Nevertheless, this effect was not observed for majority of the samples. Remeasurements of long-term stored samples give mostly the same 14C ages for ultrafiltered ones and for those without ultrafiltration.