bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wind-Driven Response of the Northern Indian Ocean to Climate Extremes*
Authors: Jensen Tommy G. 
Published: June 2007

Abstract
Composites of Florida State University winds (1970–99) for four different climate scenarios are used to force an Indian Ocean model. In addition to the mean climatology, the cases include La Niña, El Niño, and the Indian Ocean dipole (IOD). The differences in upper-ocean water mass exchanges between the Arabian Sea and the Bay of Bengal are investigated and show that, during El Niño and IOD years, the average clockwise Indian Ocean circulation is intensified, while it is weakened during La Niña years. As a consequence, high-salinity water export from the Arabian Sea into the Bay of Bengal is enhanced during El Niño and IOD years, while transport of low-salinity waters from the Bay of Bengal into the Arabian Sea is enhanced during La Niña years. This provides a venue for interannual salinity variations in the northern Indian Ocean.
A Diagnostic Study of the Indian Ocean Dipole Mode in El Niño and Non–El Niño Years
Authors: Drbohlav Hae-Kyung Lee , Gualdi Silvio , Navarra Antonio 
Published: June 2007

Abstract
The Indian Ocean dipole mode (IODM) is examined by comparing the characteristics of oceanic and atmospheric circulations, heat budgets, and possible mechanisms of IODM between El Niño and non–El Niño years. Forty-year ECMWF Re-Analysis (ERA-40) data, Reynolds SST data, and ocean assimilation data from the Modular Ocean Model are used to form composites of the IODM that occur during El Niño (1972, 1982, and 1997) and non–El Niño (1961, 1967, and 1994) years. In El Niño years, two off-equatorial, anticyclonic circulations develop, associated with the increased pressure over the eastern Indian Ocean. The anticyclonic circulation over the Northern Hemisphere enhances the easterly component of the winds in the northwestern Indian Ocean. This enhanced easterly component increases the mixed layer temperature by inducing an anomalous westward ocean current that advects the warm mean mixed layer from the central to the western Indian Ocean. Meanwhile, the anticyclonic circulation over the southeastern Indian Ocean strengthens southeasterlies, thereby causing oceanic meridional and vertical advection of the cold mean temperature. Consequently, the IODM in El Niño years is characterized by the warming in the northwestern and the cooling in the southeastern Indian Ocean. In non–El Niño years, a monsoonlike wind flow increases the westerly and southeasterly components of the wind over the northwestern and southeastern Indian Ocean, respectively. Oceanic currents induced by these winds result in anomalous cold advection in both of these regions. In addition, the monsoonlike wind flow over the southeastern Indian Ocean enhances the anomalous latent and sensible heat fluxes in non–El Niño years. Hence, the cooling of the eastern tropical Indian Ocean, rather than the warming of the western Indian Ocean, becomes the major feature of the IODM during non–El Niño years.
Modeling the Variability of the Greater Agulhas Current System
Authors: Hermes J. C. , Reason C. J. C. , Lutjeharms J. R. E. 
Published: June 2007

Abstract
An eddy-permitting, regional ocean model has been used to examine the variability in the source regions of the Agulhas Current on a range of time scales. These source regions are the East Madagascar Current, the flow through the Mozambique Channel, and the recirculation of the southwest Indian Ocean. The effect of variability in these source regions on the interocean leakage at the Agulhas retroflection south of Africa has been quantified using a retroflection index.
On the annual mean, the recirculation in the southwest Indian Ocean subgyre is by far the dominant contribution to the volume transport of the Agulhas Current in the model. On average the recirculation also contributes the largest amount of heat, although the difference between the three sources is not as great as that seen in the volume flux since the water in the Mozambique Channel may be warmer than in the recirculation. Local winds seem to be the dominant forcing mechanism of variability in this recirculation, although it is also partly in phase with the zonally averaged wind stress curl over the subtropical Indian Ocean. A strong relationship was found between the transport of the recirculation and that of the Agulhas Current, particularly on interannual time scales.
Consistent with observations, the model flow through the Mozambique Channel is dominated by eddies, with a strong annual cycle, lagging the South Equatorial Current by 1 month and a weaker semiannual cycle. The southern limb of the East Madagascar Current also shows an annual and semiannual variation in transport at 20°S, partly in phase with the local winds. South of about 24°S, the East Madagascar Current breaks up into eddies.
An investigation into the sensitivity of the flows in the source regions and in the retroflection index to a 2° southward shift in the mean winds was conducted. In the model run with the shifted winds, the transport strengthened in the recirculation subgyre together with increased mesoscale activity as well as reduced leakage into the southeast Atlantic Ocean when the winds were shifted south by 2°.
Explorations of the Annual Mean Heat Budget of the Tropical Indian Ocean. Part II: Studies with a Simplified Ocean General Circulation Model
Authors: Hu Rui-Jin , Godfrey J. Stuart 
Published: June 2007

Abstract
Present-day OGCMs give low values of annual mean net heat flux (AMNHF) in the tropical Indian Ocean, compared to climatologies. AMNHF generation is examined in an open-boundary model of this region with realistic coastlines. In the first two of three experiments only annual mean wind stresses were applied so that a modified form of the “minimum depth criterion” of the previous paper would be applicable. Area-integrated AMNHF was well below observed values, despite the fact that western boundary inflow was substantially deeper and colder than was expected from the modified minimum depth estimate. The model showed large “spikes” in the gradient of “depth-integrated steric height” (DISH) along the western boundary, coinciding with coastline steps (which were absent in the previous paper). Most diapycnal entrainment occurred next to the coast, near these steps. In a third experiment a seasonal cycle of wind stress was added to the same annual mean. Annual mean diapycnal mixing and entrainment increased and the western boundary inflow deepened, resulting in substantially greater AMNHF for the same annual mean Ekman transports. However, area-integrated AMNHF was still well below the mean of directly observed surface fluxes. The recirculation around the “Great Whirl” doubled, permitting more cold water crossing the equator in one year to mix with recirculated water generated in a previous year. Entrainment up to the surface thus went by stages, over more than one year. The increased Great Whirl was related to stronger annual mean curls of nonlinear terms in the momentum equation, while the deeper entrainment was caused by stronger annual mean diapycnal mixing. In all experiments, diapycnal mixing was primarily due to the “flux corrected transport” (FCT) advective scheme, which in effect replaces spurious convective overturn by numerical diffusion. More research is needed to solve such problems, but sensitivity of AMNHF in OGCMs to time-varying forcing—due to seasonal, intraseasonal, or baroclinic instability—may offer a new source of climate predictability.
Modeling Decadal Changes on the Indian Ocean Section I5 at 32°S
Authors: Murray R. J. , Bindoff Nathaniel L. , Reason C. J. C. 
Published: June 2007

Abstract
A near-global ocean model with resolution enhanced in the southern Indian Ocean has been spun up to seasonal equilibrium and then driven by NCEP–NCAR reanalysis 1 monthly mean forcings and Hadley SSTs over the period 1948–2002. The aim was to simulate changes in the subsurface properties observed in hydrographic surveys at 32°S in the Indian Ocean in 1965, 1987, and 2002. These surveys showed a zonally averaged cooling on isopycnals of 0.5° and 0.3°C in mode and intermediate waters between 1965 and 1987 and a warming of the mode water coupled with a continued cooling of the intermediate water between 1987 and 2002. The major changes in isopycnal depth and temperature modeled in this study were confined to the mode water and were qualitatively similar to those observed but concentrated in a lower density class and in the eastern half of the section. The dominant changes here were multidecadal, with maximum temperatures on the σθ = 26.7 kg m−3 isopycnal being reached in 1968 and minimum temperatures in 1990. The simulations showed a propagation of interannual anomalies toward the section from a region of deep late winter mixed layers in the southeast Indian Ocean within a period of several years. Surface temperatures in this region were lowest in the 1960s and highest in the late 1980s. Temperatures on isopycnals showed the opposite variation, consistent with SST having the controlling effect on mixed layer density and depth. Isopycnal depths within the mode water were strongly correlated with temperature, implying a redistribution of mode water density classes, the greatest volume of mode water being produced in a higher density class (σθ = 26.8–27.0 kg m–3) during the period of cooler surface forcing in the 1960s and 1970s than during the warmer period following (σθ = 26.6–26.8 kg m–3).
Functional characterization of two melanocortin (MC) receptors in lamprey showing orthology to the MC1 and MC4 receptor subtypes
Authors: Haitina Tatjana , Klovins Janis , Takahashi Akiyoshi , Löwgren Maja , Ringholm Aneta , Enberg Johan , Kawauchi Hiroshi , Larson Earl T , Fredriksson Robert , Schiöth Helgi B 
Published: June 2007

Abstract

Background
The melanocortin (MC) receptors have a key role in regulating body weight and pigmentation. They belong to the rhodopsin family of G protein-coupled receptors (GPCRs). The purpose of this study was to identify ancestral MC receptors in agnathan, river lamprey.

Results
We report cloning of two MC receptors from river lamprey. The lamprey receptors, designated MCa and MCb, showed orthology to the MC1 and MC4 receptor subtypes, respectively. The molecular clock analysis suggested that lamprey MC receptor genes were not duplicated recently and diverged from each other more than 400 MYR ago. Expression and pharmacological characterization showed that the lamprey MCa receptor was able to bind and be activated by both lamprey and human MSH peptides. The lamprey MCa receptor had relatively high affinity for ACTH derived peptides similarly to the fish MC receptors. We found that both of the lamprey MC receptors were expressed in skin, while the MCb receptor was also found in liver, heart and skeletal muscle.

Conclusion
This study shows presence of MC receptors in agnathans indicating early signs of specific functions of melanocortin receptor subtypes.
A preliminary assessment of genetic relationships among agronomically important cultivars of black pepper
Authors: Joy Nisha , Abraham Z , Soniya EV 
Published: June 2007

Abstract

Background
The impact of diseases such as Phytophthora foot rot and the replacement of unproductive cultivars by high yielding ones has brought about the disappearance of varieties in Piper species, like any other crop. Black pepper (King of spices), is a major spice crop consumed throughout the world. It is widely cultivated across various parts of the world apart from India. The different cultivars may be genetically related and could be a source of valuable genes for disease resistance and an increase in quantity and quality. Even though Western Ghats in India is believed to be the site of origin of this crop, numerous accessions from the NBPGR have not yet been evaluated. Our study aims to investigate the genetic relatedness in major cultivars of black pepper using Amplified Fragment Length Polymorphism.

Results
Amplified Fragment Length Polymorphic (AFLP) DNA analysis was performed in thirty popular cultivars of black pepper from National Bureau of Plant Genetic Resources (NBPGR), India. Fingerprint profiles were generated initially with, five different primer combinations, from which three primer pair combinations (EAGC/MCAA, EAGG/MCTA and EAGC/MCTG) gave consistent and scorable banding patterns. From 173 scorable markers, 158(> 90%) were polymorphic which shows there is considerable variation in the available germplasm. The dendrogram derived by unweighted pair group method analysis (UPGMA) grouped the accessions into three major clusters and four diverse cultivars with only 30% similarity. Karimunda, a widely grown and popular cultivar was unique in the fingerprint profiles obtained.

Conclusion
There are currently few fingerprinting studies using the valuable spice crop black pepper. We found considerable genetic variability among cultivars of black pepper. Fingerprinting analysis with AFLP proved to be an ideal tool for cultivar identification and phylogenetic studies. It shows the high level of polymorphism and the unique characterization of the major cultivars. An extensive range of similarity value between the cultivars was noted (6.01 to 98.13). Further screening of more cultivars will provide valuable information for current breeding programmes.
Low-density cells isolated from the rat thymus resemble branched cortical macrophages and have a reduced capability of rescuing double-positive thymocytes from apoptosis in the BB-DP rat
Authors: Sommandas Vinod , Rutledge Elizabeth A , Van Yserloo Brian , Fuller Jessica , Lernmark Åke , Drexhage Hemmo A 
Published: June 2007

AbstractBiobreeding-diabetes prone (BB-DP) rats spontaneously develop organ-specific autoimmunity and are severely lymphopenic and particularly deficient in ART2+ regulatory T cells. A special breed, the so-called BB-diabetic-resistant (DR) rats, are not lymphopenic and do not develop organ-specific autoimmunity. The genetic difference between both strains is the lymphopenia (lyp) gene. Intrathymic tolerance mechanisms are important to prevent autoimmunity, and next to thymus epithelial cells, thymus APC play a prominent part in this tolerance. We here embarked on a study to detect defects in thymus APC of the BB-DP rat and isolated thymus APC using a protocol based on the low-density and nonadherent character of the cells. We used BB-DP, BB-DR, wild-type F344, and F344 rats congenic for the lyp gene-containing region. The isolated thymus, nonadherent, low-density cells appeared to be predominantly ED2+ branched cortical macrophages and not OX62+ thymus medullary and cortico-medullary dendritic cells. Functionally, these ED2+ macrophages were excellent stimulators of T cell proliferation, but it is more important that they rescued double-positive thymocytes from apoptosis. The isolated thymus ED2+ macrophages of the BB-DP and the F344.lyp/lyp rat exhibited a reduced T cell stimulatory capacity as compared with such cells of nonlymphopenic rats. They had a strongly diminished capability of rescuing thymocytes from apoptosis (also of ART2+ T cells) and showed a reduced Ian5 expression (as lyp/lyp thymocytes do). Our experiments strongly suggest that branched cortical macrophages play a role in positive selection of T cells in the thymus and point to defects in these cells in BB-DP rats.
The Depression Scale as a screening instrument for a subsequent depressive episode in primary healthcare patients
Authors: Poutanen Outi , Koivisto Anna-Maija , Joukamaa Matti , Mattila Aino , Salokangas Raimo K. R. 
Published: June 2007

BackgroundThere are numerous instruments for screening for depression. A feasible screen is good at both recognising and predicting depression.AimsTo study the ability of the Depression Scale and its items to recognise and predict a depressive episode.MethodA sample of patients attending primary care was examined in 1991–1992 and again 7 years later. The accuracy of the Depression Scale at baseline and at follow-up was tested against the Short Form of the Composite International Diagnostic Interview (CIDI-SF) diagnosis of depression at follow-up. The sensitivity and specificity of the Depression Scale and its items were assessed.ResultsBoth baseline and follow-up Depression Scale scores were consistent with the CIDI–SF diagnoses. It was possible to find single items efficient at both recognising and predicting depression.ConclusionsThe Depression Scale is a useful screening instrument for depression, with both diagnostic and predictive validity.
Impact of sexual violence on disclosure during Home Office interviews
Authors: Bögner Diana , Herlihy Jane , Brewin Chris R. 
Published: June 2007

BackgroundLate disclosure or nondisclosure during Home Office interviews is commonly cited as a reason to doubt an asylum seeker's credibility, but disclosure may be affected by other factors.AimsTo determine whether and how sexual violence affects asylum seekers' disclosure of personal information during Home Office interviews.MethodTwenty-seven refugees and asylum seekers were interviewed using semi-structured interviews and self-report measures.ResultsThe majority of participants reported difficulties in disclosing. Those with a history of sexual violence reported more difficulties in disclosing personal information during Home Office interviews, were more likely to dissociate during these interviews and scored significantly higher on measures of posttraumatic stress symptoms and shame than those with a history of non-sexual violence.ConclusionsThe results indicate the importance of shame, dissociation and psychopathology in disclosure and support the need for immigration procedures sensitive to these issues. Judgments that late disclosure is indicative of a fabricated asylum claim must take into account the possibility of factors related to sexual violence and the circumstances of the interview process itself.
Meeting NICE self-harm standards in an accident and emergency department
Authors: Hughes Leah , Kosky Nick 
Published: June 2007

Aims and MethodAn audit in a general hospital accident and emergency (A&E) department and the subsequent development of a triage process for people presenting with self-harm is described. A random sample of 103 people attending with self-harm were selected and their treatment audited against standards derived from NICE guidelines.ResultsThe service provided by the A&E department was sub-standard. Of particular concern was the lack of processes addressing risk assessment and safe discharge. A pro forma was designed with the aim of improving assessment of self-harm. A repeat audit 3 months after introduction of the pro forma showed an improvement in the recording of relevant information underpinning risk assessment.Clinical ImplicationsProcedures for those presenting to A&E departments with self-harm may not meet recommended guidelines. The use of a pro forma with staff training can improve risk assessment.
Reproductive and Sexual Function After Platinum-Based Chemotherapy in Long-Term Ovarian Germ Cell Tumor Survivors: A Gynecologic Oncology Group Study
Authors: Gershenson David M. , Miller Anna M. , Champion Victoria L. , Monahan Patrick O. , Zhao Qianqian , Cella David , Williams Stephen D. 
Published: June 2007

Purpose To compare malignant ovarian germ cell tumor survivors with a matched control group of females on menstrual and reproductive outcomes, sexual functioning, and dyadic adjustment. Patients and Methods Eligible patients met the following criteria: (1) history of malignant ovarian germ cell tumor; (2) treatment with surgery plus platinum-based chemotherapy; (3) age at least 18 years and continuously disease-free with minimum follow-up of 2 years; (4) capability of completing questionnaire and telephone interview; and (5) completion of written informed consent. The control group was drawn from acquaintances recommended by survivors and matched for age, race, and education. Scales with established reliability and validity were used to measure quality-of-life concepts of sexual functioning and social networks. Results One hundred thirty-two survivors and 137 controls completed the study. Of 132 survivors, 71 (53.8%) had fertility-sparing surgery. Of fertile survivors, 62 (87.3%) reported still having menstrual periods. Twenty-four survivors reported 37 offspring after cancer treatment. Compared with controls, survivors had significantly greater reproductive concerns (P < .0001), less sexual pleasure (P = .003), and lower scores on the total Sexual Activity Scale Score (P = .001). However, survivors had better dyadic consensus (P = .004), dyadic satisfaction (P = .005), and dyadic cohesion (P = .014). Conclusion Women who had fertility-sparing surgery were very likely to retain menstrual function and fertility after chemotherapy. Although there is some increase in gynecologic symptoms and diminution in sexual pleasure, survivors tended to have stronger, more positive relationships with significant others.
Bevacizumab 5 mg/kg Can Be Infused Safely Over 10 Minutes
Authors: Reidy Diane L. , Chung Ki Y. , Timoney John P. , Park Vivian J. , Hollywood Ellen , Sklarin Nancy T. , Muller Raymond J. , Saltz Leonard B. 
Published: June 2007

Purpose Bevacizumab is a humanized monoclonal antibody that targets vascular endothelial growth factor. As a result of concerns for potential infusion-related hypersensitivity reactions (HSRs), initial phase I trials used a 90-, 60-, 30-minute initial infusion sequence. We sought to determine if the initial prolonged infusion was still necessary and if an infusion time of fewer than 30 minutes could be safely used. Methods We used computerized pharmacy records to identify all patients who received bevacizumab at our institution in the first 2 years of commercial availability (February 1, 2004, to June 30, 2006). Our institutional adverse drug reaction reporting program was used to identify any infusion reactions possibly related to bevacizumab, and patient medical records were reviewed for confirmation. Results A total of 1,077 patients were treated with 10,606 doses of bevacizumab, and 765 of these patients received a 5-mg/kg dose (total of 8,494 doses). No HSRs occurred with the 90-, 60-, 30-minute infusion sequence in the first 202 patients. The standard infusion rate was then modified to 30 minutes for all bevacizumab doses. No HSRs were encountered. The infusion was again modified to a rate of 0.5 mg/kg/min. Of the 370 patients who received a total of 2,311 doses of bevacizumab at 5 mg/kg over 10 minutes, six (1.6%) experienced events of minor clinical consequence that were possibly consistent with nonserious HSRs. Conclusion Ninety- and 60-minute initial infusion times are unnecessary. Use of a standard infusion rate of 0.5 mg/kg/min is safe, logical, and the current policy at our institution.