bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bioclimatic influence on water chemistry and dissolved organic matter in shallow temperate lakes of Andean Patagonia: A gradient approach
Authors: Mansilla Ferro Carolina , Garcia Patricia E. , Reissig Mariana , Diéguez María C. 
Published: March 2024

Abstract

We addressed the influence of bioclimatic variables (precipitation, temperature and vegetation) on physicochemical properties, carbon (C) and nutrients dynamics in shallow temperate lakes in the northern Patagonian Andes.

Four shallow lakes (mean depth < 15 m) located along the Andean Patagonian bioclimatic gradient, and characterised by a west‐to‐east decrease in precipitation, increase in temperature and changes in vegetation type, were studied during wet and dry periods. Physicochemical variables, total nitrogen and phosphorus (TN and TP) and particulate and dissolved organic matter (POM and DOM) were analysed. Multivariate analyses were performed to evaluate the influence of environmental variables on lake water chemistry and to identify the main factors associated with spatial and temporal differences in lake DOM pools.

Spatial and seasonal decreases in precipitation and warming were reflected in reduced hydrological connectivity of the lakes. The reduced connectivity resulted in increased conductivity, pH, alkalinity, dissolved organic carbon (DOC) and TN concentrations. Such conditions favoured the loss of lake DOM aromaticity, humic content and molecular weight/size, and increased the degradation signals and the biologically produced DOM fraction.

Lakes responded uniformly to changes in climate variables along the Andean Patagonian gradient. Differences among lakes in water chemistry and DOM composition, were associated at the gradient scale with variation in precipitation, temperature and catchment vegetation, which may provide insights into C and water chemistry trajectories under forecasted climate trends.

Our results suggest that drought and warming trends could result in less hydrological connectivity, shrinking terrestrial DOM fluxes to lakes while concomitantly increasing internal degradation processes.
How cosmopolitan capital shapes the valuation of international credentials: A comparative analysis across cities in China and the United Arab Emirates
Authors: Delval Anne‐Sophie 
Published: March 2024

AbstractThis study investigates the career paths of 33 graduates from Swiss Hospitality Management schools in China and the United Arab Emirates (UAE), exploring the nuances of international credential valuation. It identifies two key factors influencing access to management positions: (1) the degree of internationalization in major cities, which impacts the significance of international versus local skills and (2) individual cosmopolitan capital's role in shaping local career opportunities. The paper introduces a post‐colonial conceptualization of cosmopolitan capital, encompassing institutionalized, embodied and objectified forms, challenging Western‐centric views. By doing so, it reveals how mechanisms of racialization influence the assessment of international qualifications. In Hong Kong and Shanghai, returning Chinese are prospering in corporate head offices by mobilizing both local/national and international capital, challenging the white privilege of Western managers in this sector. Meanwhile, in Dubai and Abu Dhabi, the competition is for a pool of ‘international talent’, even though being perceived as ‘Arab’ or ‘white’ seems to improve career prospects.
Force‐sensing treadmill gait analysis system can detect gait abnormalities in haemophilia patients without arthropathy
Authors: Mawarikado Yuya , Sakata Asuka , Inagaki Yusuke , Harada Suguru , Tatsumi Kohei , Matsumoto Naoki , Ogiwara Kenichi , Yada Koji , Yoshimura Yasushi , Kido Akira , Tanaka Yasuhito , Shima Midori , Nogami Keiji 
Published: March 2024

AbstractBackgroundJoint damage in patients with haemophilia (PwH) is commonly assessed by imaging, but few reports have described how structural changes in joints, for example, haemophilic arthropathy (HA)—affect gait ability.ObjectivesWe evaluated gait function among PwH with HA, PwH without HA, and people without haemophilia (non‐PwH) using a Zebris FDM‐T treadmill (FDM‐T), an easy‐to‐use gait assessment instrument with a force sensor matrix.MethodsThe following gait parameters were collected: centre of pressure trajectory intersection (COPi) anterior/posterior variability, COPi lateral variability, COPi anterior/posterior symmetry, COPi lateral symmetry, single‐limb support line (SLSL) length, and SLSL variability. Participants walked at their typical gait speed. The physical function of the PwH was assessed by the Hemophilia Joint Health Score (HJHS). Parameters were compared among the three groups.ResultsTwelve PwH with HA, 28 PwH without HA, and 12 non‐PwH were enrolled. Gait speed significantly differed between groups (non‐PwH, 3.1 ± 0.7; PwH without HA, 2.0 ± 0.7; PwH with HA; 1.5 ± 0.4). The COPi anterior/posterior variability, COPi lateral variability, SLSL length, and SLSL variability were greater in the PwH groups than in the non‐PwH group. The COPi lateral symmetry differed between PwH with HA and the other groups. The HJHS was not correlated with gait parameters among PwH with HA.ConclusionsGait parameters and speed were abnormal in both PwH with HA and PwH without HA. The FDM‐T can be used to identify early stages of physical dysfunction that cannot be detected by conventional functional assessments such as the HJHS.
Traveling salesman problem with drone and bicycle: multimodal last‐mile e‐mobility
Authors: Babaee Tirkolaee Erfan , Cakmak Emre , Karadayi‐Usta Saliha 
Published: March 2024

AbstractRecently, the multimodal last‐mile e‐mobility concept has been at the center of attention for cleaner, greener, and more accessible urban deliveries. As part of sustainable transportation systems, multimodal e‐mobility is proper for a variety of logistics operations as well as medical applications. This work tries to address a novel application of multimodal e‐mobility through introducing and modeling the traveling salesman problem with drone and bicycle (TSP‐D‐B). Therefore, a novel mixed integer linear programming model is developed to formulate the problem wherein the total traveling time is minimized. As part of the last‐mile delivery, a fleet of three vehicles including a truck, a drone, and a bicycle is taken into account to serve the customers in a single visit. The truck is considered as the main vehicle, while the drone and bicycle can be preferred in case of emergencies such as traffic or route failures. In order to assess the complexity, validity and applicability of the offered model, a dataset including 64 different benchmarks is generated, and according to the findings, the model is able to efficiently solve the benchmarks for up to 50 customers in 685 s maximum. A comparison is also made between TSP‐D‐B, the classic version of the TSP and the TSP‐D, which reveals that TSP‐D‐B provides appropriate service time savings in all benchmarks. Finally, another comparative analysis is made using several instances adapted from the literature. It is revealed that TSP‐D‐B leads to significant time savings in most instances.
Identification of circRNA‐disease associations via multi‐model fusion and ensemble learning
Authors: Yang Jing , Lei Xiujuan , Zhang Fa 
Published: March 2024

AbstractCircular RNA (circRNA) is a common non‐coding RNA and plays an important role in the diagnosis and therapy of human diseases, circRNA‐disease associations prediction based on computational methods can provide a new way for better clinical diagnosis. In this article, we proposed a novel method for circRNA‐disease associations prediction based on ensemble learning, named ELCDA. First, the association heterogeneous network was constructed via collecting multiple information of circRNAs and diseases, and multiple similarity measures are adopted here, then, we use metapath, matrix factorization and GraphSAGE‐based models to extract features of nodes from different views, the final comprehensive features of circRNAs and diseases via ensemble learning, finally, a soft voting ensemble strategy is used to integrate the predicted results of all classifier. The performance of ELCDA is evaluated by fivefold cross‐validation and compare with other state‐of‐the‐art methods, the experimental results show that ELCDA is outperformance than others. Furthermore, three common diseases are used as case studies, which also demonstrate that ELCDA is an effective method for predicting circRNA‐disease associations.
Hedan tablet ameliorated non‐alcoholic steatohepatitis by moderating NF‐κB and lipid metabolism‐related pathways via regulating hepatic metabolites
Authors: Guo Liying , Lei Jinyan , Li Peng , Wang Yuming , Wang Jing , Song Taotao , Zhu Bo , Jia Jianwei , Miao Jing , Cui Huantian 
Published: March 2024

AbstractNon‐alcoholic steatohepatitis (NASH) is a severe form of fatty liver disease. If not treated, it can lead to liver damage, cirrhosis and even liver cancer. However, advances in treatment have remained relatively slow, and there is thus an urgent need to develop appropriate treatments. Hedan tablet (HDP) is used to treat metabolic syndrome. However, scientific understanding of the therapeutic effect of HDP on NASH remains limited. We used HDP to treat a methionine/choline‐deficient diet‐induced model of NASH in rats to elucidate the therapeutic effects of HDP on liver injury. In addition, we used untargeted metabolomics to investigate the effects of HDP on metabolites in liver of NASH rats, and further validated its effects on inflammation and lipid metabolism following screening for potential target pathways. HDP had considerable therapeutic, anti‐oxidant, and anti‐inflammatory effects on NASH. HDP could also alter the hepatic metabolites changed by NASH. Moreover, HDP considerable moderated NF‐κB and lipid metabolism‐related pathways. The present study found that HDP had remarkable therapeutic effects in NASH rats. The therapeutic efficacy of HDP in NASH mainly associated with regulation of NF‐κB and lipid metabolism‐related pathways via arachidonic acid metabolism, glycine‐serine‐threonine metabolism, as well as steroid hormone biosynthesis.
Competitive endogenous RNA networks: Decoding the role of long non‐coding RNAs and circular RNAs in colorectal cancer chemoresistance
Authors: Khalafizadeh Ali , Hashemizadegan Seyedeh Donya , Shokri Fatemeh , Bakhshinejad Babak , Jabbari Keyvan , Motavaf Mahsa , Babashah Sadegh 
Published: March 2024

AbstractColorectal cancer (CRC) is recognized as one of the most common gastrointestinal malignancies across the globe. Despite significant progress in designing novel treatments for CRC, there is a pressing need for more effective therapeutic approaches. Unfortunately, many patients undergoing chemotherapy develop drug resistance, posing a significant challenge for cancer treatment. Non‐coding RNAs (ncRNAs) have been found to play crucial roles in CRC development and its response to chemotherapy. However, there are still gaps in our understanding of interactions among various ncRNAs, such as long non‐coding RNAs (lncRNAs), circular RNAs (circRNAs) and microRNAs (miRNAs). These ncRNAs can act as either oncogenes or tumour suppressors, affecting numerous biological functions in different cancers including CRC. A class of ncRNA molecules known as competitive endogenous RNAs (ceRNAs) has emerged as a key player in various cellular processes. These molecules form networks through lncRNA/miRNA/mRNA and circRNA/miRNA/mRNA interactions. In CRC, dysregulation of ceRNA networks has been observed across various cellular processes, including proliferation, apoptosis and angiogenesis. These dysregulations are believed to play a significant role in the progression of CRC and, in certain instances, may contribute to the development of chemoresistance. Enriching our knowledge of these dysregulations holds promise for advancing the field of diagnostic and therapeutic modalities for CRC. In this review, we discuss lncRNA‐ and circRNA‐associated ceRNA networks implicated in the emergence and advancement of drug resistance in colorectal carcinogenesis.
Identification and characterization of extrachromosomal circular DNA in large‐artery atherosclerotic stroke
Authors: Chen Kejie , Chi Yanqi , Cheng Hang , Yang Min , Tan Quandan , Hao Junli , Lin Yapeng , Mao Fengkai , He Song , Yang Jie 
Published: March 2024

AbstractExtrachromosomal circular DNA (eccDNA) is a new biomarker and regulator of diseases. However, the role of eccDNAs in large‐artery atherosclerotic (LAA) stroke remains unclear. Through high‐throughput circle‐sequencing technique, the length distribution, genomic characteristic and motifs feature of plasma eccDNA from healthy controls (CON) and patients with LAA stroke were analysed. Then, the potential functions of the annotated eccDNAs were investigated using GO and KEGG pathway analyses. EccDNAs mapped to the reference genome showed SHN3 and BCL6 were LAA stroke unique transcription factors. The genes of differentially expressed eccDNAs between LAA stroke patients and CON were mainly involved in axon/dendrite/neuron projection development and maintenance of cellular structure via Wnt, Rap1 and MAPK pathways. Moreover, LAA stroke unique eccDNA genes played a role in regulation of coagulation and fibrinolysis, and there were five LAA stroke unique eccDNAs (Chr2:12724406‐12724784, Chr4:1867120‐186272046, Chr4:186271494‐186271696, Chr7:116560296‐116560685 and Chr11:57611780‐5761192). Additionally, POLR2C and AURKA carried by ecDNAs (eccDNA size >100 kb) of LAA stroke patients were significantly associated with development of LAA stroke. Our data firstly revealed the characteristics of eccDNA in LAA stroke and the functions of LAA stroke unique eccDNAs and eccDNA genes, suggesting eccDNA is a novel biomarker and mechanism of LAA stroke.
Distal‐to‐proximal etiologically relevant variables associated with the general (p) and specific factors of psychopathology
Authors: Ormel Jonah , Vos Melissa , Laceulle Odilia M. , Vrijen Charlotte , van der Laan Camiel M. , Nolte Ilja M. , Hartman Catharina A. 
Published: March 2024

BackgroundThe general factor of psychopathology, often denoted as p, captures the common variance among a broad range of psychiatric symptoms. Specific factors are co‐modeled based on subsets of closely related symptoms. This paper investigated the extent to which wide‐ranging genetic, personal, and environmental etiologically relevant variables are associated with p and specific psychopathology factors.MethodsUsing data from four waves (ages 11–19) of TRAILS, we modeled a bifactor model of p and four specific factors [internalizing, externalizing, ADHD, Autism Spectrum Disorder (ASD)]. Next, we examined the associations of 19 etiologically relevant variables with these psychology factors using path models that organized the variables according to the distal‐to‐proximal risk principle.ResultsCollectively, the etiologically relevant factors, including temperament traits, accounted for 55% of p's variance, 46% in ADHD, 35% in externalizing, 19% in internalizing, and 7% in ASD. The low 7% is due to insufficient unique variance in ASD indicators that load more strongly on p. Excluding temperament, variables accounted for 29% variance in p, 9% ADHD, 14% EXT, 7% INT, and 4% ASD. Most etiologically relevant factors were generic, predicting p. In addition, we identified effects on specific factors in addition to effects on p (e.g., parental SES, executive functioning); only effects on specific factors (e.g., parental rejection); opposite effects on different factors [e.g., diurnal cortisol (high INT but low EXT, p); developmental delay (high ASD and p but low EXT)]. Frustration, family functioning, parental psychopathology, executive functioning, and fearfulness had strong effects on p.Conclusions(1) Strong generic effects on p suggest that etiologically relevant factors and psychopathology tend to cluster in persons. (2) While many factors predict p, additional as well as opposite effects on specific factors indicate the relevance of specific psychopathology factors in understanding mental disorder. (3) High frustration, neurodevelopmental problems, and a disadvantaged family environment primarily characterize p.
Racial and ethnic differences in disease course Medicare expenditures for beneficiaries with dementia
Authors: Olchanski Natalia , Zhu Yingying , Liang Lichen , Cohen Joshua T. , Faul Jessica D. , Fillit Howard M. , Freund Karen M. , Lin Pei‐Jung 
Published: March 2024

AbstractBackgroundResearch on racial and ethnic disparities in costs of care during the course of dementia is sparse. We analyzed Medicare expenditures for beneficiaries with dementia to identify when during the course of care costs are the highest and whether they differ by race and ethnicity.MethodsWe analyzed data from the 2000–2016 Health and Retirement Study (HRS) linked with corresponding Medicare claims to estimate total Medicare expenditures for four phases: (1) the year before a dementia diagnosis, (2) the first year following a dementia diagnosis, (3) ongoing care for dementia after the first year, and (4) the last year of life. We estimated each patient's phase‐specific and disease course Medicare expenditures by using a race‐specific survival model and monthly expenditures adjusted for patient characteristics. We investigated healthcare utilization by service type across races/ethnicities and phases of care.ResultsAdjusted mean total Medicare expenditures for non‐Hispanic (NH) Black ($165,730) and Hispanic beneficiaries with dementia ($160,442) exceeded corresponding expenditures for NH Whites ($136,326). In the year preceding and immediately following initial dementia diagnosis, mean Medicare expenditures for NH Blacks ($26,337 and $20,429) exceeded expenditures for Hispanics and NH Whites ($21,399–23,176 and 17,182–18,244). The last year of life was responsible for the greatest cost contribution: $51,294 (NH Blacks), $47,469 (Hispanics), and $39,499 (NH Whites). These differences were driven by greater use of high‐cost services (e.g., emergency department, inpatient and intensive care), especially during the last year of life.ConclusionsNH Black and Hispanic beneficiaries with dementia had higher disease course Medicare expenditures than NH Whites. Expenditures were highest for NH Black beneficiaries in every phase of care. Further research should address mechanisms of such disparities and identify methods to improve communication, shared decision‐making, and access to appropriate services for all populations.
Do dental anxiety and satisfaction with dental professionals modify the association between affordability and dental service use? A population‐based longitudinal study of Australian adults
Authors: Shahid Mishel , Tadakamadla Santosh Kumar , Kroon Jeroen , Peres Marco A. 
Published: March 2024

AbstractObjectivesThis study aimed to assess the association between affordability in terms of difficulty paying dental bills in Australian dollars and dental service use in the presence of sociodemographic confounders, and to assess the role of dental anxiety and satisfaction with dental professionals as mediators. The second aim was to investigate how dental anxiety and satisfaction with dental professionals modify the association between affordability and use of dental services in Australian adults.MethodsLongitudinal data from the Australian National Study of Adult Oral Health (2004–06 and 2017–18) was used. Poisson regression and path analysis were conducted to determine the association between affordability and frequency of use of dental services. Effect measure modification (EMM) analysis was performed by stratification of dental anxiety and satisfaction with dental professionals.ResultsThe study included 1698 Australian adults and identified that the prevalence of low frequency of dental visits was 20% more for those who had difficulty paying dental bills. Adults with dental anxiety (prevalence ratio [PR] = 1.14) and those who were dissatisfied with dental professionals (PR = 1.17) had a higher prevalence of low frequency of dental visits in the presence of difficulty paying dental bills. This indicated that dental anxiety and dissatisfaction with dental professionals were effect modifiers on this pathway.ConclusionsAdults who experience dental anxiety and dissatisfaction with dental professionals are more likely to avoid dental visits when faced with difficulty paying dental bills. However, it is important to note that these associations do not necessarily imply a causal relationship.
Aspergillus nodules: Natural history and the effect of antifungals
Authors: Kosmidis Chris , Achira Mahmoud , Yong Jeremy , Harris Chris , Bazaz Rohit 
Published: March 2024

AbstractBackgroundAspergillus nodules are classified as a subset of chronic pulmonary aspergillosis. The optimal management approach is not known as their natural evolution following biopsy, the rate of progression to chronic cavitary pulmonary aspergillosis (CCPA) and the effect of antifungal treatment have not been described.ObjectivesTo describe the clinical course of patients diagnosed with Aspergillus nodules and the effect of antifungal treatment.Patients/MethodsWe present a series of 23 patients with histologically confirmed Aspergillus nodules and describe serial imaging, antifungal treatment and progression to other diagnoses.ResultsThirteen patients were diagnosed after a CT‐guided biopsy and 10 after surgical resection. Among those who had CT‐guided biopsy, 8 did not receive antifungal treatment; the nodule was stable or smaller in all cases on subsequent CT scan after a mean of 15.5 months. However, one patient developed squamous cell carcinoma after 16 months and another developed CCPA after 7 months. Among the 5 patients who received antifungals for at least 4 weeks, the nodule was smaller in 1 and stable in 4. One patient developed CCPA 3 years after the biopsy. No patient who had a surgical resection subsequently had a CCPA diagnosis.ConclusionMost Aspergillus nodules remained stable or improved following biopsy, irrespective of the effect of antifungals. However, CCPA can develop occasionally in patients with Aspergillus nodules and ongoing radiological follow‐up may be warranted when the nodule is not resected.
Finding meaning in complex care nursing in a hospital setting
Authors: Borghmans Felice , Laletas Stella , Fernandes Venesser , Newnham Harvey 
Published: March 2024

AbstractThis study explores the experiences of nurses that provide ‘complex’, generalist healthcare in hospital settings. Complex care is described as care for patients experiencing acute issues additional to multimorbidity, ageing or psychosocial complexity. Nurses are the largest professional group of frontline healthcare workers and patients experiencing chronic conditions are overrepresented in acute care settings. Research exploring nurses’ experiences of hospital‐based complex care is limited, however. This study aims to add to what is known currently. Four ‘complex care’ nurses undertook in‐depth semistructured interviews and their narratives were analysed using the conceptual framework of complex adaptive phenomenology. Two overarching themes constituting the ‘essence’ of complex care nursing were identified: Contextual factors and attribute/value‐based elements. Creating meaningful patient outcomes and feeling part of a team were experienced as fulfilling, whereas time constraints, institutional settings and systemic barriers to comprehensive caregiving diminished the experience of providing complex care. Overall, work meaning presented as a dynamic phenomenon, shaped by personal and professional values, local settings and systemic factors. It is recommended that more expansive research be undertaken to explore the experience of complex care for nurses. Such knowledge can contribute to initiatives that draw a skilled, effective and engaged hospital‐based complex care nursing workforce.