bluuebunny/crossref_metadata_2025_split huggingface dataset:
The First Session of the Eightieth Congress
Authors: Riddick Floyd M. 
Published: May 2006

The Eightieth Congress convened under unusual circumstances. The Legislative Reorganization Act of 1946 having just become law, the House and Senate were subjected to the most complete reorganization of recent times. This was due to two things.First, both parties in each house had to assign de novo every one of their members to the newly established committees. Normally, all members reëlected to Congress are returned to their same committee assignments. Thus the committees on committees are not concerned with giving them committee appointments; some transfers from one committee to a more important one are granted upon request to reëlected members, and promotions are allowed by moving up reëlected members to fill any vacancies on their committees created by defeats or resignations from Congress. This time, the number of committee assignments was curtailed under the law along with a sharp reduction in the number of standing committees. In the House, standing committees were reduced from 48 to 19; in the Senate, from 33 to 15. The shake-up called for a reëxamination of all candidates for every committee berth.Secondly, party control of the two houses had shifted from the Democrats to the Republicans, and in the face of a Democratic Administration. President Truman acknowledged this latter situation in his State of the Union message when he said: “… The Congress and the President, during the next two years, must work together. It is not unusual in our history that the majority of the Congress represents a party in opposition to the President's party. I am the twentieth President of the United States who, at some time during his term of office, has found his own party to be in the minority in one or both Houses of the Congress. … On some domestic issues,” he continued, “we may, and probably shall, disagree. That in itself is not to be feared.”
Trends in Recurring and Chronic Food Insecurity Among US Families With Older Adults
Authors: Leung Cindy W. , Insolera Noura E. , Wolfson Julia A. 
Published: March 2024

ImportanceFood insecurity is a critical social determinant of health for older adults. Understanding national food insecurity trends among families with older adults has important policy implications.ObjectiveTo compare food insecurity trends among US families with an older adult from 1999 to 2003 and 2015 to 2019 and further stratify the analysis by race and ethnicity, socioeconomic status markers, and enrollment in the federal Supplemental Nutrition Assistance Program (SNAP).Design, Setting, and ParticipantsIn this cohort study using biennial data from the nationally representative Panel Study of Income Dynamics, balanced panels of families with at least 1 older adult (≥60 years) who participated from 1999 to 2003 (n = 1311) and 2015 to 2019 (n = 2268) were created. Analysis was completed in 2023.Main outcomeFood insecurity was assessed using the US Household Food Security Survey Module. Within each 5-year period, we defined recurring food insecurity as 2 or more episodes of food insecurity and chronic food insecurity as 3 episodes of food insecurity.ResultsOverall, food insecurity among US families with older adults increased from 12.5% in 1999 to 2003 to 23.1% in 2015 to 2019. Rates of recurring food insecurity more than doubled (5.6% to 12.6%), whereas rates of chronic food insecurity more than tripled (2.0% to 6.3%). Across both time periods, higher rates of food insecurity persisted among Black and Hispanic families, with lower socioeconomic status, and participating in SNAP.Conclusions and RelevanceThese results highlight how rates of recurring and chronic food insecurity among families with older adults rose substantially over the past 20 years. Monitoring national trends in food insecurity among older adults has direct programmatic and policy implications.
Current traditional Chinese medicine treatments of psoriasis vulgaris
Authors: Luo Ying , Song Jiankun , Kuai Le , Zheng Qi , Wang Mingxia , Deng Guoshu , Zhang Ying , Li Xin , Wang Ruiping , Li Bin 
Published: March 2024

AbstractPsoriasis is a kind of immune‐mediated chronic skin disease induced by combined genetic and environmental factors. The effective and safe treatment of psoriasis has always been a challenge in dermatology clinics. Traditional Chinese medicine (TCM), an important direction for the current treatment of psoriasis, is characterized by historical significance, unique characteristics, and rich experience. In recent years, the “hemo‐modulating therapy” of TCM has reached a consensus with excellent progress in the treatment of psoriasis. This paper reviews the current TCM treatments of psoriasis and discusses the possibilities for psoriasis disease management.
Identification of potential biomarkers for neuromyelitis optica by quantitative proteomics
Authors: Ding Yaowei , Chen Yuxin , Sun Jialu , Shi Yijun , Li Guoge , Luan Xin , Wang Siqi , Li Xiaotong , Jiang Wencan , Wang Lijuan , Zhang Guojun 
Published: March 2024

AbstractObjectiveNeuromyelitis optica (NMO) was a serious autoimmune inflammatory condition affecting the central nervous system. Currently, there was a lack of diagnostic biomarkers for AQP4‐IgG‐negative NMO patients.MethodsA comparative proteomic analysis was conducted on the CSF of 10 patients with NMO and 10 patients with non‐inflammatory neurological disorders (NND) using tandem mass tagging technology. Differentially expressed proteins (DEPs) were analyzed using bioinformatic methods. The candidate proteins were then validated through ELISAs in a subsequent cohort of 160 samples, consisting of paired CSF and plasma samples from 50 NMO patients, CSF samples from 30 NND patients, and plasma samples from 30 healthy individuals.ResultsWe identified 389 proteins via proteomics, screening 79 DEPs. NCAM1, SST and AHSG were selected as candidate molecules for further validation. Compared to NND patients, there were decreased levels of AHSG in CSF and increased levels of NCAM1 and SST in NMO patients. The ELISA results revealed significantly higher levels of AHSG, SST and NCAM1 in the CSF of the NMO group compared to the NND group. Similarly, the serum levels of these three proteins were also higher in the NMO group compared to the healthy control group. It was found that serum NCAM1 levels significantly decreased in patients with non‐relapsed NMO compared to patients with relapsed NMO and CSF NCAM1 level increased in patients with bilateral NMO compared to patients with unilateral NMO. Furthermore, CSF SST levels increased in AQP4 antibody‐positive NMO patients compared to AQP4 antibody‐negative patients.InterpretationCSF NCAM1, serum NCAM1 and serum SST may serve as potential biomarkers for NMO patients and aid in the diagnosis of AQP4 antibody‐negative NMO patients.
Unveiling the Growth Mechanism of Ordered‐Phase within Multimetallic Nanoplates
Authors: Mahmood Azhar , He Dequan , Liu Chuhao , Talib Shamraiz Hussain , Zhao Bolin , Liu Tianren , He Ying , Chen Lijuan , Han Dongxue , Niu Li 
Published: March 2024

AbstractTuning the crystal phase of alloy nanocrystals (NCs) offers an alternative way to improve their electrocatalytic performance, but, how heterometals diffuse and form ordered‐phase remains unclear. Herein, for the first time, the mechanism for forming tetrametallic ordered‐phase nanoplates (NPLs) is unraveled. The observations reveal that the intermetallic ordered‐phase nucleates through crystallinity alteration of the seeds and then propagates by reentrant grooves. Notably, the reentrant grooves act as intermediate NCs for ordered‐phase, eventually forming intermetallic PdCuIrCo NPLs. These NPLs substantially outperform for oxygen evolution reaction (221 mV at 10 mA cm−2) and hydrogen evolution reaction (19 mV at 10 mA cm−2) compared to commercial Ir/C and Pd/C catalysts in acidic media. For OER at 1.53 V versus RHE, the PdCuIrCo/C exhibits an enhanced mass activity of 9.8 A mg−1Pd+Ir (about ten times higher) than Ir/C. For HER at ‐0. 2 V versus RHE, PdCuIrCo/C shows a remarkable mass activity of 1.06 A mg−1Pd+Ir, which is three‐fold relative to Pd/C. These improvements can be ascribed to the intermetallic ordered‐structure with high‐valence Ir sites and tensile‐strain. This approach enabled the realization of a previously unobserved mechanism for ordered‐phase NCs. Therefore, this strategy of making ordered‐phase NPLs can be used in diverse heterogeneous catalysis.
Risk of weed seed and seedling emergence from poultry litter
Authors: Kulesza Stephanie B. , Leon Ramon G. , Sosinski Stephanie C. , Kilroy Grace M. , Meis Brittani , Castillo Miguel S. , Wilson Melissa L. 
Published: March 2024

AbstractIn areas surrounding large poultry industries, poultry litter is often an alternative nitrogen fertilizer for crop production. However, farmers who have not used poultry litter in the past have concerns regarding potential weed seed contamination. A survey was conducted to determine the occurrence of germinable weed seed in poultry litters (n = 61) submitted by growers and industry representatives across North Carolina. In a 9:1 potting media:poultry litter mix, a single grass seed germinated from the 61 surveyed poultry litters, equating to 0.3 viable seeds 100 g−1 poultry litter. Viable seed content averaged 1.1 seeds 100 g−1 litter using the extractable seedbank method on 25% of the litters from the survey, much higher than the grow out method, and the majority of seeds found were Amaranthaceae. A growth chamber experiment was then conducted and demonstrated that there was a negative relation between poultry litter application and weed seedling emergence. There was a 65%, 75%, and 85% reduction in Senna obtusifolia (L.) H.S. Irwin & Barneby, Setaria pumila (Poir.) Roem. & Schult., and Amaranthus palmeri S. Watson germination, respectively, from the control to highest application rate of poultry litter (26.9 Mg ha−1). A laboratory study showed that poultry litter leachates can decrease seed radicle length and integrity and is likely due to osmotic or salinity stress. The weed seed content in litter as well as the negative impact of poultry litter and its leachates on weed seedling emergence make it unlikely that poultry litter applications will significantly increase seedbanks above levels commonly observed in agricultural fields.
Tracking interactions between TAMs and CAFs mediated by arginase‐induced proline production during immune evasion of HCC
Authors: Wu Chuanchen , Mao Yuantao , Qi Xinru , Wang Xin , Li Ping , Zhang Wen , Tang Bo 
Published: March 2024

AbstractSynergistic changes between tumor‐associated macrophages (TAMs) and cancer‐associated fibroblasts (CAFs) aggravated immune evasion of hepatocellular carcinoma (HCC), however, the underlying molecular mechanisms remain elusive. Their continuous and dynamic interactions are subject to bioactive molecule changes. A real‐time and in situ monitoring method suitable for in vivo research of these processes would be indispensable but is scarce. In this study, a dual imaging strategy that tracing the TAMs and CAFs simultaneously was developed using a new arginase‐specific probe and established CAFs‐specific probe. The emerging roles of arginase in mediating CAFs activation in mice were explored. Results showed arginase up‐regulation in TAMs, followed by proline increase. Subsequently, proline produced by TAMs initiated the activation of CAFs. Through the JAK‐STAT signaling, CAFs up‐regulated the PD‐L1 and CTLA‐4, ultimately promoting immune evasion of HCC. This study revealed a new mechanism by which TAMs and CAFs collaborate in immune evasion, providing new targets for HCC immunotherapy.
Global variations in eruption chronology of permanent teeth: A systematic review and meta‐analysis
Authors: Vandana S. , Muthu M. S. , Akila G. , Anusha M. , Kandaswamy D. , Aswath Narayanan M. B. 
Published: March 2024

AbstractObjectivesPopulation‐based variations have been reported in permanent teeth eruption but only sparse literature exists on the same. A systematic review and meta‐analysis were performed to assess the global variations in eruption chronology of permanent teeth in children and adolescents and the role of sexes, jaws and classes of socio‐economic status (SES) on timing of eruption was explored.MethodsThe protocol for the systematic review was registered in PROSPERO. An extensive search of PubMed, EMBASE, Google Scholar, EBSCO, Cochrane library, and anthropology databases was carried out until April 2023. Additionally, grey literature search and hand‐searching of relevant key journals was done.ResultsOverall, 3797 cross‐sectional and longitudinal studies were retrieved from multiple databases. A total of 939, 191 participants were included from 80 studies of which, 41 were carried out in Asia, 26 in Europe, 5 in Africa, 4 in North America, and 4 in Oceania. The mandibular first molar eruption was found to be as early as 4.09 years while the maxillary second molar erupted as late as 13.45 years. Using a random effects model, 28 forest plots were generated. Meta‐regression interpreted tooth eruption to be earlier in females and in the mandible.ConclusionsThe findings of this study show that the ages of permanent teeth eruption was advanced in the European population followed by Africa and Asia.
Genetic diversity promotes resilience in a mouse model of Alzheimer's disease
Authors: Soni Neelakshi , Hohsfield Lindsay A. , Tran Kristine M. , Kawauchi Shimako , Walker Amber , Javonillo Dominic , Phan Jimmy , Matheos Dina , Da Cunha Celia , Uyar Asli , Milinkeviciute Giedre , Gomez‐Arboledas Angela , Tran Katelynn , Kaczorowski Catherine C. , Wood Marcelo A. , Tenner Andrea J. , LaFerla Frank M. , Carter Gregory W. , Mortazavi Ali , Swarup Vivek , MacGregor Grant R. , Green Kim N. 
Published: March 2024

AbstractINTRODUCTIONAlzheimer's disease (AD) is a neurodegenerative disorder with multifactorial etiology, including genetic factors that play a significant role in disease risk and resilience. However, the role of genetic diversity in preclinical AD studies has received limited attention.METHODSWe crossed five Collaborative Cross strains with 5xFAD C57BL/6J female mice to generate F1 mice with and without the 5xFAD transgene. Amyloid plaque pathology, microglial and astrocytic responses, neurofilament light chain levels, and gene expression were assessed at various ages.RESULTSGenetic diversity significantly impacts AD‐related pathology. Hybrid strains showed resistance to amyloid plaque formation and neuronal damage. Transcriptome diversity was maintained across ages and sexes, with observable strain‐specific variations in AD‐related phenotypes. Comparative gene expression analysis indicated correlations between mouse strains and human AD.DISCUSSIONIncreasing genetic diversity promotes resilience to AD‐related pathogenesis, relative to an inbred C57BL/6J background, reinforcing the importance of genetic diversity in uncovering resilience in the development of AD.Highlights
Genetic diversity's impact on AD in mice was explored.
Diverse F1 mouse strains were used for AD study, via the Collaborative Cross.
Strain‐specific variations in AD pathology, glia, and transcription were found.
Strains resilient to plaque formation and plasma neurofilament light chain (NfL) increases were identified.
Correlations with human AD transcriptomics were observed.
Biodegradable packing food films based on PBAT containing ZnO and MoO3
Authors: da Rocha Lizandra Viana Maurat , da Silva Paulo Sergio Rangel Cruz , da Silva Eduardo Miguez Bastos , de Oliveira Aguiar Vinicius , Tavares Maria Inês Bruno 
Published: March 2024

AbstractMolybdenum trioxide (MoO3) and zinc oxide (ZnO) were incorporated into the poly(butylene adipate‐co‐terephthalate) (PBAT) matrix using casting method to obtain packing films for food transportation with outstanding properties and no formation of microplastics. Consequently, these films were evaluated using Fourier transform infrared spectroscopy, time domain and carbon‐13 nuclear magnetic resonance, x‐ray diffraction, contact angle measurement, and thermogravimetric analysis. The light barrier properties of the films were analyzed using transmittance mode in UV–VIS–NIR regions and the contact angle of composite films exhibited greater hydrophilicity compared to the pure polymer films. Regardless of the concentration, the fillers did not significantly modify the degradation onset temperature and the temperature of maximum degradation rate. However, ZnO caused a new thermal degradation event (around 330°C) that was not observed in the other films, possibly due to the second crystallization process. Composite films filled with 0.3% ZnO, 0.3% and 0.5% MoO3 showed greater molecular homogeneity than the pure polymer matrix, with the PBAT/MoO3 films demonstrating even greater homogeneity than PBAT/ZnO films; this response presumably comes from the satisfactory intermolecular interaction or adequate dispersion and distribution of the particles. The addition of 0.5% MoO3 in the matrix influenced the PBAT film, resulting in amorphous materials with the highest molecular mobility and opacity. Besides, in view of antimicrobial tests, all nanocomposites showed potential bacteriostatic activity. So, it can be conveniently used for food transportation and may avoid microplastic formation, after been discarded.
Acu‐URO17 is a highly sensitive and specific bladder cancer biomarker
Authors: Guo Liwu , Cid Alexandra , Cucci John , Kunkel Brian , Defeis Lisa , Matthews Michael 
Published: March 2024

AbstractObjectiveThis study evaluates the efficacy of Acu‐URO17, a highly sensitive and specific immunocytochemistry (ICC) test targeting Keratin 17, in comparison to urine cytology and UroVysion™ fluorescence in situ hybridization (FISH) for detecting bladder cancer cells in voided urine specimens.MethodsAcupath conducted a large‐scale comparison study using 2378 voided urine specimens. Acu‐URO17, urine cytology and UroVysion™ FISH were performed on these specimens according to standardized protocols. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were calculated for Acu‐URO17 in comparison to urine cytology and UroVysion™ FISH.ResultsIn cases diagnosed with high‐grade urothelial cancer via urine cytology, Acu‐URO17 demonstrated a sensitivity of 96% and a specificity of 82%. When compared to UroVysion™ FISH results, Acu‐URO17 exhibited a sensitivity of 97.1% and a specificity of 77.8%, surpassing the sensitivity of UroVysion™ FISH (57.1%). Notably, Acu‐URO17 showed a high NPV of 99.9%, indicating its reliability in confirming negative urine cytology results and risk‐stratifying atypical and suspicious cytology results.ConclusionThe results of this large‐scale prospective study support Acu‐URO17 as a clinically relevant, non‐invasive and cost‐effective tool for detecting bladder cancer cells in voided urine specimens. Its high sensitivity, specificity and NPV make it a valuable adjunct to urine cytology and UroVysion™ FISH in the diagnosis and management of urothelial carcinoma (UC).
Lemieux‐Johnson oxidation with N,N‐bidentate bisPYA ruthenium complexes: insights into reaction conditions and catalyst design
Authors: Salzmann Kevin , Segarra Candela , Carrel Aline , Albrecht Martin 
Published: March 2024

AbstractThe carbonyl group is arguably the most versatile functional group for synthetic purposes. Here, a series of N,N’‐bis(pyridylideneamide) (bisPYA) complexes of ruthenium(II), [Ru(cym)(bisPYA)Cl]+ (cym=cymene), were synthesized and applied as catalysts for Lemieux‐Johnson oxidation of alkenes to access carbonyl functionalities. Complexes bearing para‐ and ortho‐bisPYA ligands induce higher activity and selectivity than their mesoionic meta‐bisPYA analogues. The non‐coordinating counterion of the cationic complexes affects the catalytic performance markedly, with PF6− enhancing the activity compared to trifluoromethanesulfonate, OTf−. Likewise, replacing the anionic ancillary chloride ligand by a neutral and more labile MeCN ligand led to increased activity. Electrochemical and solubility measurements revealed no direct correlation of ligand donor strength to catalytic performance. Variation of the solvent mixture and the ratio of its components provided access to high‐performance catalysts. In H2O/MeCN/CH2Cl2 at 3 : 1:0.5 (v/v) ratio, turnover frequencies up to 10,000 h−1 were obtained for the Lemieux‐Johnson oxidation of styrene with these Ru(bisPYA) complexes, allowing quantitative conversions within 30 min at 0.1 mol % catalyst loadings and corresponding to a 5 times faster reaction than the best catalyst known to date for this transformation.
Correlation between the serum FABP4, ANGPTL3, and ANGPTL4 levels and coronary artery disease
Authors: Zhao Zhuoyan , Fu Ying , Lian Huan , Liu Yixiang , Liu Jingyi , Sun Lixian , Zhang Ying 
Published: March 2024

AbstractBackgroundLipid metabolism related factors, such as angiopoietin‐like protein 3 (ANGPTL3), angiopoietin‐like 4 (ANGPTL4), fatty acid‐binding protein 4 (FABP4) are newly discovered factors that can affect coronary artery disease (CAD). In this study, we aimed to investigate the relationship between CAD and these lipid metabolism factors.HypothesisANGPTL3, ANGPTL4, and FABP4 may provide a new method for the control of CAD risk factors and the prevention and treatment of CAD.MethodsWe enrolled 284 consecutive inpatients with suspected CAD and divided them into CAD and non‐CAD groups based on the coronary angiography results. Serum ANGPTL3, ANGPTL4, FABP4, and tumor necrosis factor‐α (TNF‐α) levels were estimated using the enzyme‐linked immunosorbent assay. Multivariate logistic regression was used to assess the risk factors for CAD. The receiver operating characteristic curve was used to determine the cutoff and diagnostic values.ResultsThe serum TNF‐α, FABP4, ANGPTL3, and ANGPTL4 values showed a significant difference between the CAD and non‐CAD groups (p < .05). After adjusting for confounding factors, the FABP4, ANGPTL3, and ANGPTL4 levels were independently associated with CAD (p < .05). The ANGPTL3 expression level was an independent risk factor for CAD in patients with hypertension, but not in those without hypertension. The ANGPTL3 > 67.53 ng/mL, ANGPTL4 > 29.95 ng/mL, and FABP4 > 1421.25 ng/L combination had the highest diagnostic value for CAD.ConclusionANGPTL3, ANGPTL4, and FABP4 were identified as independent risk factors for CAD and have valuable clinical implications for the diagnosis and treatment of CAD.