bluuebunny/crossref_metadata_2025_split huggingface dataset:
Applying the Intersectionality Lens to Understand Minority Ethnic Women's Experiences of the Breast Cancer Care Pathway in England: A Qualitative Interview Study
Authors: Estupiñán Fdez. de Mesa Mar , Ferguson Maureen , Green Saran , Marcu Afrodita , Ream Emma , Whitaker Katriina L. 
Published: February 2025

ABSTRACTBackgroundExploring the role of structural power in relation to an individual's location in society can yield novel insights into cancer inequities. We aimed to understand how minority ethnic women's identities (age, gender, ethnicity, social position) intersected with social networks and healthcare services to influence their experiences of breast cancer care.MethodsSemi‐structured interviews with 20 women aged 31–60 years with a breast cancer diagnosis identifying as: Asian (n = 7), Black (n = 9), and of mixed ethnicity (n = 4) about their breast cancer journey. Data were analysed using Framework Analysis.ResultsWe developed four themes; feeling stereotyped by (a) healthcare professionals (HCPs) and (b) social networks; influence of HCPs' knowledge, attitudes, and behaviours; perceived barriers in healthcare services; and influence of cultural beliefs. We provided a visual representation to illustrate the multifaceted factors that explain pathways to breast cancer inequities for these groups.ConclusionOur findings underscored that minority ethnic women negotiated complex processes that influence their coping responses, access to services, and management of their disease. Our study exposed institutional deficiencies that systematically disadvantage minority ethnic women. These findings suggest that policymakers and clinicians should reformulate policies and cancer services to ensure all women with breast cancer receive equal and optimal care.
Unmet Needs and Health‐Related Quality of Life Among Patients With Relapsed/Refractory Indolent Non‐Hodgkin Lymphoma: A Mixed‐Methods Study
Authors: Sugimoto Miki , Yagasaki Kaori , Matsuki Eri , Shimizu Takayuki , Sakurai Masatoshi , Kataoka Keisuke , Doorenbos Ardith Z. 
Published: February 2025

ABSTRACTObjectivePatients with relapsed or refractory (r/r) indolent non‐Hodgkin lymphoma (iNHL) live with incurable disease for a long‐term, experiencing multiple relapses and treatments that impair their health‐related quality of life (HRQOL). We aimed to better understand the unmet needs and HRQOL of patients with r/r iNHL.MethodsThis convergent mixed‐methods study evaluated patients with r/r iNHL who received treatment. Unmet needs and HRQOL were assessed quantitatively using self‐administered questionnaires and analyzed statistically. Qualitative data were collected through face‐to‐face semi‐structured interviews for reflexive thematic analysis. Quantitative and qualitative findings were integrated through narrative discussion and joint display.ResultsQuestionnaire respondents (50 participants, mean age: 72.42 years) reported unmet needs in the health system and information and psychological domains and a negative association between unmet needs and HRQOL. Interviews (20 participants, mean age: 72.75 years) identified four themes: “unremarkable symptoms,” “anxiety of progression in the near future,” “make the best of life,” and “means to live with uncertainty.” Integration revealed that participants accepted their low HRQOL and attempted to make the best of life, influencing their perception of unmet needs.ConclusionsThroughout the long course of r/r and repeated treatment, patients with iNHL accepted their low HRQOL, valued their current situations, and endeavored to make the best of life. In this situation, support in the psychological and health system and information domains is crucial. Support for the unmet needs of patients with r/r iNHL is essential as they strive to live their best lives while maintaining a favorable HRQOL.
Bubbling Water‐Treating DBD Plasma Device Optimization Using Experimental and Computational Methods
Authors: Robinson Conner D. , Sponsel Nicholas L. , Stapelmann Katharina 
Published: February 2025

ABSTRACTA dry air atmospheric pressure volume dielectric barrier discharge is employed to fix nitrogen in water. Producing nitrate for use as nitrogen fertilizer is the primary motivation. A 0D chemistry model is developed and informed by the electrical, and geometric characteristics of the device and the plasma gas temperature. Modeled ozone and nitrate densities are compared to those measured experimentally in the plasma effluent and treated liquid for a range of gas temperatures. Modeled and measured ozone densities are in good agreement; however, the model lacks the liquid chemistry to properly represent the measured nitrate density. A gas temperature‐based shift from ozone to producing regimes is observed in both experiment and model, and the reactions responsible are evaluated.
Dementia and Alzheimer's Disease Associated With Aromatase Inhibitors: A Disproportionality Analysis of the WHO Pharmacovigilance Database (VigiBase)
Authors: Yuste María Teresa , Sainz‐Gil María , Escudero Elisa , Marín Pedro 
Published: February 2025

ABSTRACTAromatase inhibitors are used for patients with hormone‐receptor positive breast cancer. Alzheimer's disease is the most prevalent cause of dementia. Several studies have suggested an association between the use of aromatase inhibitors and the development of Alzheimer's disease. The objective of this study was to identify potential pharmacovigilance signals associated with dementia and Alzheimer's disease and third‐generation aromatase inhibitors in menopausal and postmenopausal women. VigiBase, the global database of individual case safety reports of the World Health Organization, was used to investigate this possible association. A disproportionality analysis was performed for women aged 45 years and older. The reporting odds ratio (ROR) and its 95% CI for reporting dementia are exemestane, 2.08 (1.35–3.19); anastrozole, 1.59 (1.09–2.32); and letrozole, 1.43 (1.05–1.95) and for Alzheimer's disease are exemestane, 0.94 (0.30–2.92); anastrozole: 2.63 (1.55–4.45); and letrozole, 1.33 (0.76–2.35). For senile dementia, only letrozole has cases, with an ROR of 6.77 (2.51–18.31). Signals of disproportionate reporting have been observed between the occurrence of dementia, dementia Alzheimer's type, and senile dementia with aromatase inhibitors, which is in line with estrogen functions and aromatase activity, as well as the findings from preclinical studies. Additional research is required to elucidate this intricate matter.
Duffing Nonlinearity‐Enhanced Optomechanical Mass Sensor
Authors: Wang Hui , Zhang Zhi‐Wen , Yang Bing‐Yu , Chao Shi‐Lei , Xiong Biao 
Published: February 2025

AbstractMeasuring the mass of small molecules is crucial across various fields, and the cavity optomechanical system is a promising candidate for mass sensing due to the direct relationship between the oscillator's resonant frequency and the mass of the sample deposited on the cavity's surface. Previous research has shown that enhancing the effective frequency of the resonator can significantly improve the performance of mass sensors. In this study, the influence of the Duffing nonlinear term is investigated on the cavity optomechanical mass sensing. These computational and numerical simulation results demonstrate that increasing the strength of the Duffing nonlinear term effectively raises the resonator's effective frequency and directly boosts the performance of the mass sensor. These include enhancing detection resolution, reducing measurement errors, and expanding the effective measurement range of mass, which may have applications in fields such as biochemical sensing and environmental monitoring.
Inverse Probability of Treatment Weighting Using the Propensity Score With Competing Risks in Survival Analysis
Authors: Austin Peter C. , Fine Jason P. 
Published: February 2025

ABSTRACTInverse probability of treatment weighting (IPTW) using the propensity score allows estimation of the effect of treatment in observational studies. We had three objectives: first, to describe methods for using IPTW to estimate the effects of treatments in settings with competing risks; second, to illustrate the application of these methods using empirical analyses; and third, to conduct Monte Carlo simulations to evaluate the relative performance of three methods for estimating time‐specific risk differences and time‐specific relative risks in settings with competing risks. In doing so, we provide guidance to applied biostatisticians and clinical investigators on the use of IPTW in settings with competing risks. We examined three estimators of time‐specific risk differences and relative risks: the weighted Aalen–Johansen estimator, an estimator that combines IPTW with inverse probability of censoring weights (IPTW‐IPCWs), and a double‐robust augmented IPTW estimator combined with IPCW (AIPTW‐IPCW). The design of our simulations reflected clinically realistic scenarios. Our simulations found that all three estimators tended to result in unbiased estimations of time‐specific risk differences and time‐specific relative risks. However, the weighted Aalen–Johansen estimator and the AIPTW‐IPCW estimator tended to result in estimates with greater precision compared to the IPTW‐IPCW estimator. In our empirical analyses, we illustrated the application of these methods by estimating the effect of statin prescribing on the risk of subsequent cardiovascular death in patients discharged from the hospital with a diagnosis of acute myocardial infarction.
Preparation of Activated Carbon/MoS2 Nanospheres Composite as Pt‐free Counter Electrode for Efficient Solid State Dye Sensitized Solar Cell
Authors: Tripathi Shivansh , Tripathi Mridula , Maurya Anshu , Chawla Priyanka 
Published: February 2025

AbstractCarbon‐based materials, particularly activated carbon generated from waste, have attracted much interest as ideal alternatives to platinum as a counter electrode in dye sensitized solar cells due to their high catalytic activity, and low cost. The use of composite materials in conjunction with activated carbon improves the performance due to its multi‐functionality. A composite paste of activated carbon from corn cobs and Molybdenum disulfide nanospheres were used to prepare a counter electrode. The prepared counter electrode exhibits low charge transfer resistance at the electrolyte‐electrode interface. The solution casting method was used to make nanocomposite polymer electrolyte films out of a blend of two polymers, polyvinyl alcohol and carboxymethyl cellulose, packed with various amounts of montmorillorite and graphene as primary and secondary nanofillers. Electrical impedance spectroscopy experiments at room temperature revealed that the addition of secondary nanofiller enhanced the electrical conductivity of the electrolyte films from 3.6 × 10−4 to 8.4 × 10−3 S cm−1 due to its capacity to form conductive layers in this polymer blend based electrolyte film. The fabricated synthetic dye based solar cell which uses an innovative counter electrode and nanocomposite polymer electrolyte outperformed platinum electrode with an efficiency of 4.34% and a fill factor of 61%.
Exploration of 1,3,4‐oxadiazoles Engrafted With Indole and Phthalimide Scaffolds as Multi Target Peroxidase, Acetylcholinesterase, and Butyrylchloinesterase Inhibitors: Synthesis, DFT Calculations, and Molecular Docking Studies
Authors: Jaishree B. , Basavarajaiah S. M. , Karunakar Prashantha , Dhonnar Sunil Laxman , Nagesh G. Y. , Punithkumar M. , Bhargav P. , Vishwas Aradhya K. J. 
Published: February 2025

AbstractHere, we present the structural and pharmacological characteristics of 2‐(4‐(5‐(3,5‐disubstituted‐1H‐indol‐2‐yl)‐1,3,4‐oxadiazol‐2‐yl)phenyl)isoindoline‐1,3‐diones 5(a‐h) as a strong antioxidant and anti‐Alzheimer's disease activity using a synergistic combination of theoretical and experimental techniques. The structures of novel compounds were analyzed by spectral analysis (IR, NMR and Mass spectrometry). DFT calculations were analyzed for the selected compounds by applying the B3LYP hybrid functional and the 6–31G (d, p) basis set. The predictions regarding ADMET properties, drug‐likeness, and toxicity, including favorable bioavailability of all the synthesized compounds were disclosed. All the newly synthesized compounds 5(a–h) were illustrated well to comparable inhibitory potentials ranging from IC50 values 12.12 ± 0.02 µM to 36.31 ± 0.26 µM, 04.08 ± 0.86 µM to 12.42 ± 0.32 µM, and 08.05 ± 0.06 µM to 26.36 ± 0.52 µM against peroxidase, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) respectively. Amongst, compound 5a showed excellent inhibitory activity with IC50 values 12.12 ± 0.02 µM, 04.08 ± 0.86, and 08.05 ± 0.06 against peroxidase, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) respectively. Finally, aforesaid compounds were taken for the in silico molecular modeling against cytochrome c peroxidase (PDB id: 2 × 08), acetylcholinesterase (PDB ID: 7E3H), and butyrylcholinesterase (PDB ID: 4BDS).
Nano‐Scale Anti‐Cancer Drug Delivery by a Zn‐Based Metal Organic Framework Carrier
Authors: Das Prasenjit , Chakraborty Gouri , Kaur Jasreen , Mandal Sanjay K. 
Published: February 2025

AbstractPorous functional metal organic frameworks (MOFs) have showcased their potential in biomedical applications, specifically in drug delivery systems (DDSs), due to high surface area, tailorable pore size, tunable functionality, etc. In this work, the efficient nano drug carrier behavior of a Zn‐MOF is reported for two highly utilized drugs, 5‐fluorouracil and calcein. It exhibits a high drug loading capacity and a slow, sustained release profile as monitored by the spectroscopic and microscopic techniques. Utilizing these two drugs, its good anticancer activity against the human breast cancer MCF‐7 cell is established.
Deep Blue Tetradentate Pt(II) Emitter Coordinated With Fused Fluorenyl N‐heterocyclic Carbene. High Efficiency, Narrow FWHM, and Superior Operational Lifetime LT95 of 290 h at 1000 cd m−2
Authors: Li Huiyang , Hung Faan‐Fung , Wu Siping , Qiu Jiangzhen , Li Cuijin , Nie Shaowei , Yang Jun , Duan Lian , Zhou Pengcheng , Cheng Gang , Che Chi‐Ming 
Published: February 2025

AbstractBlue tetradentate Pt(II) emitters and the corresponding organic light‐emitting diodes (OLEDs) are promising for next‐generation high‐resolution displays. However, developing blue Pt(II) emitters that simultaneously achieve high efficiency, high color purity, and excellent operational stability remains challenging. In this study, we developed two new high‐performance deep blue tetradentate Pt(II) emitters (Pt1 and Pt2) whose ligands contain 1‐(3,5‐di‐tert‐butylphenyl)‐9,9‐dimethyl‐1,9‐dihydrofluoreno[2,3‐d]imidazolium or 3‐(3,5‐di‐tert‐butylphenyl)‐9,9‐dimethyl‐3,9‐dihydrofluoreno[2,3‐d]imidazolium carbene moiety (DMFI). These Pt(II) emitters display excellent photophysical characteristics including high photoluminescence quantum yield (PLQY) of up to 0.90, narrow full width at half maximum (FWHM), short emission lifetime, and high horizontal transition dipole ratio of up to 0.80. As a result, deep blue phosphorescent OLEDs are fabricated with a narrow FWHM of 21 nm, a high maximum external quantum efficiency (EQEmax) of 28.6%, and Commission Internationale de l'Éclairage (CIE) coordinates of (0.13, 0.15). Even more impressively, the devices based on the deuterated co‐host system and different device structures achieved an unprecedented excellent device lifetime LT95 of 290 h at an initial luminance of 1000 cd m−2, an EQEmax of 20.8%, and CIE coordinates of (0.14, 0.17).
Biomechanical Insights into the Proteomic Profiling of Cells in Response to Red Light Absorption
Authors: Silva Antônio V. S. , Sousa Felipe D. , Sousa Brandon F. , Santos Wallace V. , Oliveira Antônio E. R. , Lobo Marina D. P. , Ramos Márcio V. , Alencar Nylane M. N. , de Sousa Marcelo V. P. , Freire Rosemayre S. , Oliveira Cláudio L. N. , de Sousa Jeanlex S. 
Published: February 2025

AbstractPhotobiomodulation (PBM) is a promising non‐invasive therapy for tissue repair, but its underlying cellular mechanisms are not fully understood. In this study, the biomechanical and proteomic responses of three cell types – keratinocytes (HACAT), fibroblasts (L929), and osteoblasts (OFCOLII) – exposed to red light (633 nm) are investigated using atomic force microscopy (AFM) and mass spectrometry‐based proteomic analysis. Red light absorption resulted in cell‐type‐specific changes in viscoelastic properties, with fibroblasts exhibiting increased fluidity, reduced stiffness, and enhanced motility. Conversely, keratinocytes exhibited intensity‐dependent responses, while osteoblasts appeared to be relatively insensitive to irradiation conditions. Proteomic profiling identified key signaling pathways involved in immune response, ATP production, and stress regulation. The immune and ATP pathways are strongly linked to the modulation of viscoelastic properties, particularly in fibroblasts, while weaker correlations were observed in keratinocytes. Cytoskeletal remodeling, primarily within the F‐actin network, is identified as the main driver of mechanical alterations, with additional contributions from microtubules and intermediate filaments. These findings provide new insights into how red light absorption modulates cellular viscoelasticity through cytoskeletal remodeling, with potential applications in optimizing light‐based therapies for tissue regeneration and disease treatment.
Optimized Proton Assistance of Ni‐Intercalated Bilayer Vanadate Cathode for High‐Performance Aqueous Manganese Storage
Authors: Li Yunbo , Jin Yan , Ding Lingyi , Zhu Yucheng , Zhou Hongyan , Fan Qinghua , Dong Youzhong , Kuang Quan , Zhao Yanming 
Published: February 2025

AbstractMn metal has become a highly promising candidate anode of aqueous batteries due to its high abundance, non‐toxicity, relatively low redox potential, and large theoretical capacity. However, the development of Mn ion batteries (MIBs) is hindered by controversies over reaction mechanisms, metal hydrogen evolution reactions, and poor conversion efficiency. Therefore, a further comprehensive study is urgently desired for its research and application. In this work, a V2O5 bilayer structure is innovatively constructed by introducing stripping agents (H2O and Ni2+) to form stable “Ni─O” columns, which not only enhances the stability of the structure but also effectively blocks interlayer corrosion. The preferential orientation and the excellent interlayer spacing d (001) = 10.28 Å broads Mn2+ diffusion channels. In this way, the sites for ion storage are also increased by creating abundant vacancies, accelerating the diffusion rate of ions in the modified V2O5 (Ni0.48V2O5•0.90H2O, NiVO) lattice. The co‐storage mechanism of Mn2+/H+ ions effectively alleviates the limitations of high charge density and large solvation ion radius. Furthermore, the storage mechanism and structural evolution process are investigated via analytical chemistry. These findings provide new ideas for designing new positive electrode materials and effectively promote the progress of the MIB research and application.
Ligand‐Mediated Highly Ordered Aggregation of 5‐Mercapto‐2‐Nitrobenzoic Acid Protected Atomically Precise Silver Nanocluster
Authors: Roy Soumyadip , Tiwari Vikas , Karmakar Tarak , Chakraborty Indranath 
Published: February 2025

AbstractUnderstanding self‐assembly of atomically precise nanoclusters is of paramount interest in designing various aggregated super‐structures. Here pH‐mediated self‐assembly is reported of atomically precise Ag44(MNBA)30 (MNBA = 5‐mercapto‐2‐nitrobenzoic acid) nanoclusters in aqueous solution. These nanoclusters formed hexagonal close‐packed (hcp) structures when the pH of the solution is reduced from basic to neutral. High‐resolution transmission microscopy result confirms bilayer and multilayer assembly at neutral pH. X‐ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FTIR) analysis, and molecular dynamics simulation delineate ligand‐mediated inter‐cluster interactions such as ligand to metal core coordination, H─bonding and π–π interactions playing a crucial role in the formation of the hexagonal close‐packed self‐assembled structure.
SIB: Sorted‐Integers‐Based Index for Compact and Fast Caching in Top‐Down Logic Rule Mining Targeting KB Compression
Authors: Wang Ruoyu , Wong Raymond , Sun Daniel , Ranjan Rajiv 
Published: February 2025

BackgroundMining logic rules from structured knowledge bases is the basis of knowledge engineering. Due to the NP‐hardness of the rule mining problem, logic rules cannot be efficiently induced from knowledge bases, especially large‐scale ones.IdeaIn this article, we propose a compact and efficient index structure for the maintenance of the intermediate data during top‐down rule mining, such that the memory consumption can be reduced and mining efficiency can be improved.Developing PointsThe index is based on a mapping from constant symbols to integers and the sorting of the mapped integers. Index update has been dissembled into four basic operations. Moreover, the index itself acts as the cache during top‐down mining.ValueMost contributions in existing works employ algorithmic and architectural optimizations to improve efficiency. Data‐oriented optimizations have also been explored to some extent, but the data efficiency is relatively low, and the memory consumption is thus becoming a new challenge for state‐of‐the‐art systems. We tackle this challenge in this article, and our technique has been proven more efficient than state‐of‐the‐art systems. We evaluate our method on six datasets which contain up to 160 K records and are frequently used as benchmarks in tasks related to knowledge engineering. The experimental results show that the proposed technique speeds up the rule mining procedure by on average and reduces memory consumption by up to 70%. The space overhead of the data structure is about twice that of the indexed records, which is more than 80% lower than that of the state‐of‐the‐art technique.