bluuebunny/crossref_metadata_2025_split huggingface dataset:
TRIVIAL OR TERRIBLE? THE PSYCHOSOCIAL IMPACT OF PSORIASIS
Authors: FRIED RICHARD G. , FRIEDMAN STEVEN , PARADIS CHERYL , HATCH MARJORIE , LYNFIELD YELVA , DUNCANSON CAROL , SHALITA ALAN 
Published: May 2007

Abstract Background. Psoriasis remains a chronic disease with lesions that are often extensive and disfiguring. While the potential for psychosocial morbidity and impairment are recognized, the literature remains equivocal with regard to the prevalence and degree of this impairment. Methods. The present study utilized a new questionnaire designed to assess the type and degree of psychosocial impairment present among psoriasis patients. The questionnaire was designed to assess major areas of psychosocial functioning and was completed by 64 patients undergoing outpatient treatment. Results. Approximately half the patients were found to have moderate to extreme levels of anxiety, depression, and anger. Patients reported experiencing these negative emotional sequelae both during their disease flares and during periods of remission. Patients were also found to have moderate to extreme levels of pruritus associated with their flares. Psychologic morbidity was positively associated with length of disease flare. Significant levels of social embarrassment, life disruption, and social withdrawal were found as well. Conclusions. Psoriasis does appear to cause significant psychosocial morbidity. Greater awareness by physicians and more comprehensive treatment addressing these psychosocial components may avert, or at least minimize, some of these negative sequelae.
TREATMENT OF RECURRENT CUTANEOUS LEISHMANIASIS
Authors: MOMENI ALI‐Z. , AMINJAVAHERI MALI 
Published: May 2007

Abstract Background. Cutaneous leishmaniasis is endemic in Iran. One of the clinical pictures of this disease is leishmaniasis recidivans (LR). Most of the drugs used for cutaneous leishmaniasis are ineffective in LR. Methods and Patients. Twenty‐five patients (13 women and 12 men), who had LR and whose disease had been proved by previous direct smears, were accepted for the study. The duration of disease in all patients was more than 2 years and they had previously been treated for their cutaneous leishmaniasis by different methods. All patients were treated with a combination of allopurinol (AL) (20 mg/kg/day for 30 days) and meglumine antimoniate (MA) (70 mg/kg/day for 15 days). Laboratory tests including hemograms, liver function, and kidney function tests, were done both at baseline and at the end of therapy. Results. Twenty‐four out of 25 patients (96%) responded well to treatment and after 1 year follow‐up no relapse had occurred. The drugs were well tolerated by the patients producing no side effects nor any significant changes in laboratory values. Conclusions. A combination of AL and antimoniate is an effective method for the treatment of LR and for patients with cutaneous leishmaniasis who are resistant to the usual treatments.
OPEN RANDOMIZED COMPARISON OE ITRACONAZOLE VERSUS TERBINAEINE IN ONYCHOMYCOSIS
Authors: ARENAS ROBERTO , DOMÍNGUEZCHERIT JUDITH , FERNANDEZ LUISA MA. 
Published: May 2007

Abstract Background. Onychomycoses are among the most frequent nail diseases. The principal agents are dermatophytes, Itraconazole and terbinafine are two effective and systemic antimycotics. Previous trials have shown, that treatment schedules with effective concentrations for 3 months cause drug deposits in nail plates that persist 6 months after the end of the treatment. Methods. A comparative, open, prospective study was carried out with random assignment of patients. The first group included 27 patients under treatment with 200 mg of itraconazole once daily for 3 months. The second group included 26 patients treated with 250 mg of terbinafine for 3 months. Both series of patients were followed for 6 additional months. Results. Both groups were similar in age, sex, and history of onychomycosis, Trichophyton rubrum was the main isolated agent in all patients. The percentage of diseased nails was similar in both groups affecting predominantly the first toenail. Treatment was highly effective and differences between groups were not significant. The rate of adverse events was 21% in the itraconazole group and 47% in the terbinafine group. Conclusions. Itraconazole and terbinafine are two drugs of choice in dermatophytic onychomycosis.
HISTOLOGIC SPECTRUM OF CUTANEOUS INVOLVEMENT IN PATIENTS WITH MYELOGENOUS LEUKEMIA INCLUDING THE NEUTROPHILIC DERMATOSES
Authors: WONG TAI‐YUEN , SUSTER SAUL , BOUFFARD DANIELLE , FLYNN STUART D. , JOHNSON RICHARD A. , BARNHILL RAYMOND L. , MIHM MARTIN C. 
Published: May 2007

Abstract Background. Cutaneous manifestations of myeloid leukemia can be specific or nonspecific. The study was designed to determine the prevalence and histologic appearance of cutaneous lesions in patients with myeloid leukemia and various myeloproliferative disorders. Methods. The histologic changes of cutaneous lesions in 52 patients with myelodysplastic syndrome, polycythemia vera, and myeloid, myelomonocytic, or monocytic leukemia are presented in this study. Results. Two types of cellular infiltrates were identified. In the first group, the most common pattern was a diffuse involvement by the leukemic cells through the entire dermis with preservation of a “grenz zone” in the superficial dermis. Two cases exhibited a Kaposi's sarcoma‐like pattern, with prominent slit‐like blood‐filled spaces lined by myeloblasts against a fibrocellular stroma. The second group of lesions was characterized by dense, neutrophilic dermal infiltrates resembling acute neutrophilic dermatosis (Sweet's syndrome) or pyoderma gangrenosum. In two of these cases, scattered immature blast cells admixed with the mature neutrophilic elements were identified. Conclusions. Awareness of these different morphologic features and application of special stains are of value in the evaluation of suspicious cutaneous infiltrates in patients with myeloid leukemia and various myeloproliferative disorders.
SYSTEMIC LUPUS ERYTHEMATOSUS: A CASE‐CONTROL EPIDEMIOLOGIC STUDY IN JAPAN
Authors: NAGATA CHISATO , FUJITA SETSUYA , IWATA HIROTOSHI , KUROSAWA YUTAKA , KOBAYASHI KATSUYOSHI , KOBAYASHI MASAYO , MOTEGI KAZUO , OMURA TOSHITAKA , YAMAMOTO MASAHARU , NOSE TAKAYUKI , NAKAMURA KEN‐ICHI , HASHIMOTO TSUTOMU , NAKAMURA YOSIKAZU , YANAGAWA HIROSHI 
Published: May 2007

Abstract Background. Systemic lupus erythematosus (SLE) is designated by the Japanese government as one of the intractable diseases and all patients, who suffer from these diseases, are registered to get financial aid for treatment. Using newly registered SLE patients, a case‐control study was conducted to evaluate potential risk factors. Methods. Two‐hundred and eighty‐two women SLE patients, newly registered to receive financial aid for treatment, and 292 randomly selected health examination participants at public health centers (controls) were surveyed from April 1988 through March 1990. By means of a self‐administered questionnaire, data concerning demographic variables, smoking and drinking habits, past medical and reproductive history, and family history were collected. Results. Based on unconditional logistic regression analysis, the risk of SLE was significantly increased for current smokers (age‐adjusted odds ratio (OR) = 2.31, 95% confidence interval (CI) (1.34–3.97). Alcohol and milk intake were inversely associated with risk. Family histories of asthma and collagen diseases, including SLE, were associated with significantly elevated risk of SLE (OR = 2.07, 95% ci 1.14–3.77; OR = 5.20, 95% CI 1.08–24.95, respectively). Regarding reproductive function, women with menarche at age 15 or later had significantly higher risk than those, who started menstruating before age 12 (OR = 3.82, 95% CI 1.66–8.81 for menarche at > 15 years and OR = 2.90, 95% a 1.14–7.39 for menarche at 16y). Conclusions. Our study suggests several risk factors, including smoking, family history, and reproductive history that may increase the risk of SLE.
ISOTOPIC RESPONSE
Authors: WOLF RONNI , BRENNER SARAH , RUOCCO VINCENZO , FILIOLI FABRIZIO GRIMALDI 
Published: May 2007

Abstract Background. The occurrence of a new skin disorder exactly at the site of another one, already healed and unrelated, was first described in 1955. In 1985, Wolf et al. recognized that we are dealing with a dermatologic phenomenon and established a precise definition for this phenomenon. Fifty‐eight cases corresponding to the definition of this phenomenon have been reported until now. Methods. The new phenomenon, for which the term “isotopic response” has been suggested, has been defined. Cases corresponding to the definition have been analyzed with special emphasis on the diseases involved, the time intervals, and the locations of the diseases. Eight new cases are described. Results. A total of 58 cases of isotopic response have been described. The first disease in most of the patients was herpes zoster; in three cases it was herpes simplex, in two varicella, and in one, thrombophlebitis. The second disease, which appeared exactly at the site of the first, already healed disease, was in most reported cases a carcinoma (26 cases, in particular 15 cases of breast carcinoma, 5 basal cell carcinomas (BCC), 4 squamous cell carcinomas (sec), 2 basosquamous carcinomas), or granuloma annulare (16 cases). Additional diseases were Kaposi's sarcoma (2 cases), pseudolymphoma (2 cases), sarcoid (2 cases), tinea (2 cases), tuberculoid and vasculitis granuloma (1 case), angiosarcoma, metastasis, Bowen's disease, lymphoma, leukemia cutis, and acne (1 case each). The diseases did not show any predilection for a particular location. The interval between the first and second disease was extremely variable (ranging from days to years) and showed no particular features.In the eight additional cases described in the present report, the first disease was herpes simplex (6 cases) or herpes zoster (2 cases). The second disease was viral warts (3 cases) or squamous cell carcinoma (2 cases). Additional diseases were furunculosis, contact dermatitis, and molluscum contagiosum (1 case each). Conclusions. The new term, “isotopic response,” describes the occurrence of a new skin disorder at the site of another, unrelated, and already healed skin disease.It is suggested that the term “isotopic response” be included in the lexicon (glossary) of dermatology.Introducing the new term and classifying all the cases under a single key word, will make it possible to locate and collect them easily and to search for the mechanism underlying this phenomenon.
COMPARATIVE STUDY OF WOUND HEALING IN PORCINE SKIN WITH CO2 LASER AND OTHER SURGICAL MODALITIES: PRELIMINARY FINDINGS
Authors: MOLGAT YVONNE M. , POLLACK SHELDON V. , HURWITZ JEFFREY J. , BUNAS STANLEY J. , MANNING THOMAS , McCORMACK KEVIN M. , PINNELL SHELDON R. 
Published: May 2007

Abstract Background. The CO2 laser is a common surgical modality in dermatology. To clarify conflicting reports on the histological healing properties of CO2 laser on incisional or ablative wounds, we have applied it in a miniature hairless porcine skin model at power settings similar to those used in clinical practice. Methods. Histological parameters of wound healing in skin incisions using the CO2 laser were compared with those using scalpel, hot scalpel, and electrosection, and in dermal ablation using CO2 laser, fraize, wire brush, and electrofulguration alone or with curettage. Results. In incisional wounds, tissue damage was most extensive in CO2 laser wounds, with delayed dermal healing and reepithelialization. In ablative wounds, CO2 laser caused a similar degree of tissue damage as did the electrosurgical modalities, and more damage than did fraize or wire brush. Reepithelialization was complete in CO2 laser, fraize, and wire brush wounds before electrosurgical wounds. Final histology of both incisional and ablative wounds at 6 weeks was similar with all surgical modalities. Conclusion. The CO2 laser and electrosurgery both produce greater focal tissue damage in incisional and ablative applications than the other modalities. Delayed epithelialization of the wound occurs with both modalities in incisional wounds but only with electrosurgery in ablative wounds. At 6 weeks, the appearance of the scar in all incisional and ablative modalities is similar grossly and histologically. Confirmation of these findings requires standardization of power density of the CO2 laser in incision and ablation.
IDIOPATHIC HYPERSENSITIVITY VASCULITIS: CLINICOPATHOLOGIC CORRELATION OF 61 CASES
Authors: RATNAM KAVIPURAPU VENICATA , BOON YIM HENG , PANG BRYAN K. 
Published: May 2007

Abstract Background. Little is known of the course and prognosis of hypersensitivity vasculitis (hv). Methods. Sixty‐one cases of idiopathic hv were biopsied and followed‐up for 5 years. Results. There were two predominant patterns of presentation: palpable purpura (pp) and vasculitic ulcers (vu). The former was self‐limiting, whereas the prognosis of the latter was poor. Findings on histopathology correlate well in pp patients having acute episodes, whereas in patients with vu there is correlation with duration and recurrence. Conclusion. A biopsy of a fresh lesion is recommended to help in determining the outcome.
DEXAMETHASONE‐CYCLOPHOSPHAMIDE PULSE THERAPY FOR PEMPHIGUS
Authors: PASRICHA JAGJIT S. , KHAITAN BINOD K. , RAMAN R. SHANTHA , CHANDRA MITHILESH 
Published: May 2007

Abstract Background. During the last 12 years, we have used a different approach, arbitrarily designed by us, for treating pemphigus patients that has given us very different and encouraging results. Method. The treatment schedule consists of giving 100 mg dexamethasone on 3 consecutive days and 500 mg cyclo‐phosphamide on one day and repeating these pulses (DCPS) every 4 weeks. In between the DCPS, the patient receives only 50 mg cyclophosphamide orally daily and generally no corticosteroids. An essential component of the regimen is to administer a specified amount of the treatment for 1.5 years after achieving clinical remission. Results. Of the 300 patients enrolled for this treatment, 61 patients could not complete the treatment, whereas 12 patients have died, some of them due to unrelated causes. Of the remaining 227 patients, 190 patients (84%) have already completed the treatment and are free of the disease even after complete withdrawal of all treatment, the duration of posttreatment follow‐up being more than 5 years in 48 patients, 2 to 5 years in 75 patients, and less than 2 years in 67 patients. The maximum duration of posttreatment follow‐up is 9 years. The remaining patients are also showing the same trend. Twenty‐four patients are in remission but have not yet completed the treatment schedule, whereas 13 patients are still having evidence of clinically active disease, although it has already become much milder. The blood levels of intercellular antibody also decrease as the treatment progresses. The side effects commonly observed during treatment with corticosteroids are generally absent or insignificant. The relapses of the disease, seen so far in 59 patients, have been observed mostly in those patients who defaulted during the treatment, but a further course of the DCP regimen led again to complete recovery.
TOPICAL NICOTINAMIDE COMPARED WITH CLINDAMYCIN GEL IN THE TREATMENT OF INELAMMATORY ACNE VULGARIS
Authors: SHALITA ALAN R. , SMITH J. GRAHAM , PARISH LAWRENCE CHARLES , SOFMAN MICHAEL S. , CHALKER DAN K. 
Published: May 2007

Abstract Background. Systemic and topical antimicrobials are effective in the treatment of inflammatory acne vulgaris; however, widespread use of these agents is becoming increasingly associated with the emergence of resistant pathogens raising concerns about microorganism resistance and highlighting the need for alternative nonantimicrobial agents for the treatment of acne. Nicotinamide gel provides potent antiinflammatory activity without the risk of inducing bacterial resistance. Methods. In our double‐blind investigation, the safety and efficacy of topically applied 4% nicotinamide gel was compared to 1% clindamycin gel for the treatment of moderate inflammatory acne vulgaris. Seventy‐six patients were randomly assigned to apply either 4% nicotinamide gel (n = 38) or 1% clindamycin gel (n = 38) twice daily for 8 weeks. Efficacy was evaluated at 4 and 8 weeks using a Physician's Global Evaluation, Acne Lesion Counts, and an Acne Severity Rating. Results. After 8 weeks, both treatments produced comparable (P = 0.19) beneficial results in the Physician's Global Evaluation of Inflammatory Acne; 82% of the patients treated with nicotinamide gel and 68% treated with clindamycin gel were improved. Both treatments produced statistically similar reductions in acne lesions (papules/pustules; −60%, nicotinamide vs. −43%, clindamycin, P = 0.168), and acne severity (−52% nicotinamide group vs. −38% clindamycin group, P = 0.161). Conclusions. These data demonstrate that 4% nicotinamide gel is of comparable efficacy to 1% clindamycin gel in the treatment of acne vulgaris. Because topical clindamycin, like other antimicrobials, is associated with emergence of resistant microorganisms, nicotinamide gel is a desirable alternative treatment for acne vulgaris.
AGE AND GENDER DIFFERENCES IN THE IMPACT OF PSORIASIS ON QUALITY OF LIFE
Authors: GUPTA MADHUUKA A. , GUPTA ADITYA K. 
Published: May 2007

Abstract Background. The impact of psoriasis upon the quality of life contributes significantly to the overall morbidity associated with the disease. An older age at onset of psoriasis and being a man have been associated previously with lower psychosocial morbidity. In order to further evaluate these potentially important mitigating factors, we examined the relation of age and gender on some aspects of psoriasis‐related psychosocial morbidity. Methods. Two hundred and fifteen consenting psoriasis patients, representing a wide range of disease severity, were studied. They included 110 men and 105 women, age range 19–87 years (age: mean ± SD: 48·0 ± 15·9 years); all endorsed a list of 30 items (by checking a “Yes” or “No”) pertaining to life events related to psoriasis that they had experienced in the previous one month. The patients self‐rated the severity of their psoriasis. The patients were categorized into four age groups of 18–29 years (N = 28), 30–45 years (N = 77), 46–65 years (N = 76), and > 65 years (N = 34), respectively, for the statistical analyses. Results. No age or gender differences in the severity of psoriasis were observed. Patients of both sexes in the 18 to 29 and 30 to 45 year age groups reported more frequent (P 0·05) problems related to both appearance/socialization and occupation/finances, in contrast to patients in the 46–65 and over‐65‐year age groups. No gender differences (P 0·05) were observed in the frequency of items related to appearance and socialization; however, men reported greater work‐related stresses. Conclusion. Psoriasis has a greater impact upon the quality of life of patients in the 18 to 45 year age range and affects the socialization of both sexes equally. Men face greater work‐related stresses as a result of their psoriasis.
MULTIPLE GIANT DISSEMINATED PYOGENIC GRANULOMA IN THREE PATIENTS BURNED BY BOILING MILK
Authors: MOMENI ALI‐Z , ENSHAIEH SHAHLA , SODIFI MANOUCHEHR , AMINJAWAHERI MALI 
Published: May 2007

Abstract Background. Pyogenic granuloma is a common benign skin tumor. The multiple disseminated form of the disease is relatively rare. Methods. We examined three patients who developed giant pyogenic granuloma after burns from boiling milk. The patients were a 1.5‐year‐old boy, a 5‐year‐old girl, and a 35‐year‐old woman, All three patients had second‐degree burns over their face and trunk. Results. In these patients, pyogenic granuloma had developed over the previously burned areas 2–3 weeks after exposure. The general condition of the patients remained good and all lesions involuted spontaneously. In a 6‐month follow‐up period no relapse of the lesions was seen. Conclusions. The cause for development of multiple giant pyogenic granulomas after burns from milk remains unknown, but milk proteins or other components of milk, microorganisms, or the burn itself may be causative factors.
FINASTERIDE INHIBITS 5α‐REDUCTASE ACTIVITY IN HUMAN DERMAL FIBROBLASTS: PREDICTION OF ITS THERAPEUTIC APPLICATION IN ANDROGEN‐RELATED SKIN DISEASES
Authors: NGUYEN QUAN H. , CHEN TAO , WANG XUESHENG , CHEN YING , CHIEN PAUL 
Published: May 2007

Abstract Background. The potential role of finasteride in treating androgen related skin disorders was investigated. Methods. Pooled human dermal fibroblasts were used to assess the effect of finasteride on the 5α‐reductase activity in skin tissue. Vmax and Km were estimated in the presence of 0, 10, and 200 nM finasteride. Results. Vmax values remain constant near 1.20 pmol/mg protein/h in the presence of increasing concentrations of finasteride; however, apparent Km increases from 0.27 nM at 0 nM finasteride to 0.31 nM and 0.44 nM at 10 nM and 200 nM finasteride, respectively. This suggests that ministered competes with testosterone and has a high affinity for same binding site of the 5α‐reductase enzyme. Apparent Ki was estimated at 282 nM, indicating that a high concentration of finasteride is required to significantly suppress the enzyme activity. Conclusions. This study confirms that finasteride inhibits the conversion of testosterone to dihydrotestosterone in human reticular dermal fibroblasts. Finasteride may have therapeutic potential in treating skin disorders influenced by the action of dihydrotestosterone.
EFFECT OF SYSTEMIC ADMINISTRATION OF ISOTRETINOIN ON BLOOD LIPIDS AND FATTY ACIDS IN ACNE PATIENTS
Authors: OSTLERE LUCY S. , HARRIS DAVID , MORSE‐FISHER NANCY , WRIGHT STEPHEN 
Published: May 2007

Abstract Background. In many studies, an increase in total cholesterol and triglycerides with isotretinoin therapy have been shown and investigators have commented on potential cardiovascular risk. A low intake of linoleic acid, the main essential fatty acid in man, may act as an independent risk factor for coronary heart disease. In vitro etretin alters both the incorporation of extracellular fatty acids into cell membranes and the fatty acid composition of the cell membrane itself. It is, therefore, important to establish whether isotretinoin has any effect on the metabolism of polyunsaturated fatty acids. Methods. The effect of treatment with isotretinoin for 4 months on the metabolism of polyunsaturated fatty acids in patients with acne was assessed. Quantitative total cholesterol and triglycerides as well as plasma phospholipid, triglycerides, and cholesteryl ester fatty acids were measured in 12 patients and red cell phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositol fatty acids were measured in 13 patients before and after isotretinoin therapy. Results. There was a significant increase in the concentrations of cholesterol (P < 0.02) and triglycerides (P < 0.04) during treatment. There was no significant difference in plasma phospholipids, triglycerides, and cholesterol esters, or in the red cell phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositol during isotretinoin therapy. Conclusions. This study failed to demonstrate any effect of isotretinoin on the metabolism of polyunsaturated fatty acids. There was a significant increase in total cholesterol and triglyceride levels following isotretinoin therapy supporting the findings of many previous studies.