bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intratendon sheath corticosteroid treatment of rheumatoid arthritis‐associated and idiopathic hand flexor tenosynovitis
Authors: Gray Robert G. , Kiem Iris M. , Gottlieb Norman L. 
Published: February 2007

AbstractFlexor tenosynovitis (FT) is a common manifestation of rheumatoid arthritis (RA), contributing to hand deformity and manual dysfunction. The efficacy of intratendon sheath corticosteroids was assessed by reviewing the results of such treatment in 173 episodes of FT documented in 46 patients with definite or classic RA. Ninety‐three percent of initial episodes resolved completely for 3 or more months (median: 25 months); tenosynovitis did not recur in 59%. The likelihood of a favorable response did not diminish with treatment of recurrent FT in a given digit. Comparable results were found in 52 FT episodes observed in 38 non‐RA patients. No tendon sheath or soft tissue infection or tendon rupture ensued in either treatment group. The response was influenced by the specific corticosteroid preparation selected. Based on this experience, a trial of intratendon sheath corticosteroid injections prior to surgical intervention is recommended for RA patients with FT.
Micromeasurement of plasma salicylate in arthritic children
Authors: Jacobs Jerry C. , Pesce Michael 
Published: February 2007

AbstractA micromethod has been developed for determination of plasma salicylate. Frequent determinations of plasma salicylate levels in children with juvenile rheumatoid arthritis may be expected to provide greater therapeutic efficacy with reduced incidence of aspirin toxicity and consequently less need for use of secondary, more toxic, agents.
Methyl ester of n‐formylmethionyl‐leucyl‐phenylalanine. Chemotactic responses of human blood monocytes and inhibition of gold compounds
Authors: Ho Peter P. K. , Young Anna L. , Southard George L. 
Published: February 2007

AbstractN‐formylmethionyl‐leucyl‐phenylalanine, a potent chemotactic peptide for human polymorphonuclear leukocytes, is less chemotactic for human blood monocytes. Esterification of the N‐formylated tripeptide enhances its chemotactic activity for monocytes by more than 4 logs, whereas a decrease by 3 logs is observed for polymorphonuclear leukocytes. These results indicate the participation of the C‐terminal carboxyl group in chemotaxis of different cell types. We have also observed the selective inhibition of chemotactic responsiveness of human blood monocytes by a clinically useful antirheumatic drug, sodium aurothiomalate. Since this is the first in vitro cell migration model of inflammation in which gold compounds have demonstrated activity in micromolar concentrations, it suggests a site of action for this antirheumatic drug.
Effect of altered lymphocyte function on immunologic disorders in nzb/nzw mice.
Authors: Mehta Jagdish , Knotts Linda , Craig Carolyn , Burkholder Sharon , Miller Christine , Hahn Bevra 
Published: February 2007

AbstractAdministration of thymosin fraction V to NZB/NZW F1 mice, an animal model for human SLE, accelerated the appearance of proteinuria and anti‐nDNA antibodies, increased deposition of immunoglobulins in kidneys, and significantly shortened survivals. Although the addition of thymosin to in vitro cultures of spleen and lymph node cells from thymosin‐treated mice increased DNA synthesis in response to stimulation with Con A, in vivo treatment with thymosin did not affect the Con A response. There was no effect on in vitro responses to PHA or LPS, or on IgM antibody formation to SRBC (T cell dependent) or SSS III (T cell independent) immunizations. Antibodies to thymosin or contamination of our thymosin preparations with nucleic acids could not be demonstrated. The acceleration of autoimmune disease produced by thymosin treatment could not be explained by alteration of the T and B cell functions studied.
Therapeutic studies in NZB/NZW mice.
Authors: Steinberg Alfred D. , Krakauer Randall , Reinertsen James L. , Klassen Lynell W. , Ilfeld David , Reeves J. Patton , Williams Gary W. , Antonovych Tatiana 
Published: February 2007

AbstractSpleen cells from normal mice were cultured with Concanavalin A to produce an immunosuppressive supernate. This supernate was used to treat the lupus‐like autoimmune disease of NZB/NZW mice. Such treated mice lived significantly longer than did controls, but only if treatment was initiated early in the course of the illness.
Quantitative sacroiliac scintigraphy in patients with crohn' disease
Authors: Davis Paul , Thomson Alan B. R. , Lentle Brian C. 
Published: February 2007

AbstractSixty patients with Crohn' disease have been assessed radiologically and by quantitative sacroiliac scintigraphy for evidence of sacroilitis and/or ankylosing spondylitis. The incidence of radiologic sacroiliitis (11%) and ankylosing spondylitis (5%) was no greater in our series than previously reported. However, the incidence of increased uptake of radiotracer at the sacroiliac joints was 52%. There was no correlation in the group as a whole between radiologic and/or scintigraphic evidence of sacroiliitis and the tissue antigen HLA‐B27.
Demonstration of anticollagen antibodies in rheumatoid arthritis synovial fluids by 14c‐radioimmunoassay
Authors: Menzel Johannes , Steffen Carl , Kolarz Gernot , Kojer Marina , Smolen Josef 
Published: February 2007

AbstractTwenty‐seven synovial fluids from rheumatoid arthritis (RA) patients and 17 synovial fluids from controls were investigated in a new radioimmunoassay for anticollagen antibodies. In vitro labeled human 14C‐collagen of type I in native or denatured state was used as antigen. Passive hemagglutination was used in comparison. Parameters for defining positive results in radioimmunoassay were evaluated on the basis of control synovial fluids. Synovial fluids from 20 RA patients (74%) showed antibodies to denatured collagen; synovial fluids from 8 RA patients (30%) also demonstrated antibodies to native collagen. Control fluids of posttraumatic effusions were negative; among the other controls synovial fluid from 1 psoriatic arthritis patient reacted positively. Inhibition experiments showed that antibodies to denatured collagen cross‐reacted with native collagen. Inhibition with human denatured type III collagen displayed strong cross‐reactivity of anti–type I collagen antibodies with type III collagen.
Vertebral sarcoidosis with paravertebral ossification
Authors: Perlman Susan G. , Damergis John , Witorsch Phillip , Cooney F. Donald , Gunther Stephen F. , Barth Werner F. 
Published: February 2007

AbstractA young black male with sarcoidosis developed quadriplegia after a fall. Roentgenograms of the spine revealed extensive lytic and sclerotic changes with paravertebral bony bridges simulating ankylosing spondylitis. He recovered on corticosteroid therapy after laminectomy and cervical fusion. Review of the literature suggests that this case of vertebral sarcoidosis is the most severe yet reported and the first with paravertebral ossification.
Fibrinogen Turnover in Progressive Systemic Sclerosis
Authors: Gratwick Geoffrey M. , Klein Ronald , Sergent John S. , Christian Charles L. 
Published: February 2007

AbstractLarge amounts of fibrin are seen in the intima of the renal arterioles in progressive systemic sclerosis (scleroderma). The half‐life or half disappearance time of plasma fibrinogen in 15 patients with scleroderma was studied using 125I fibrinogen to find whether there is an increased turnover of plasma fibrinogen paralleling this morphologic abnormality. Patients had a more rapid fibrinogen turnover than normal controls (60.7 versus 90.6 hours); the subgroup of patients with “progressive” scleroderma had a more rapid fibrinogen half‐life than those with “stable” scleroderma (56.5 versus 73.2 hours). The mean fibrinogen half‐life of 8 patients given intravenous heparin increased to within one standard deviation of normal, a finding that suggested that the fibrinogen molecule in these patients was capable of normal survival. There was a considerable variation of fibrinogen half‐lives in individual scleroderma patients over time (not seen in the normal controls) which may be the result of intermittently increased fibrinogen consumption.
Total hip replacement in children with arthritis
Authors: Singsen B. H. , Isaacson A. S. , Bernstein B. H. , Patzakis M. J. , Kornreich H. K. , King K. K. , Hanson V. 
Published: February 2007

AbstractFourteen children with juvenile rheumatoid arthritis and two with ankylosing spondylitis received 29 total hip replacements (THR). The ages at THR were 12 to 18 years, the median duration of prior hip disease was 7.1 years, and the minimum followup was one year (range 1–4 years, median 2.2 years). The primary indication for THR was pain in 5 hips and severe malposition or flexion contractures in 24 hips. (Sixteen of these also had some degree of pain.) All 29 hips demonstrated improved postoperative range of motion, and all were free of pain. In children, active rheumatic disease in other joints, prosthesis longevity, and possible lack of adequate motivation all merit special consideration prior to THR, but the results are encouraging.
Inorganic pyrophosphatase activity of the synovial fluid.
Authors: Jacobelli Sergio , Kettlun Ana María , Sapag‐Hagar Mario 
Published: February 2007

AbstractInorganic pyrophosphatase activity has been partially characterized in joint fluid and determined in patients with sporadic and familial chondrocalcinosis and their controls. Optimal pH was established at 3.5 and Km values were estimated. Ca‐2 and Mg‐2 did not affect this activity whereas orthophosphate (Pi) strongly inhibited it. In the clinical study no significant differences were found among groups. This suggests that if a pyrophosphatase defect is present it might be localized in joint tissue and not be reflected in synovial fluid.
Vertebral ankylosing hyperostosis (forestier's disease) and hla antigens in pima indians
Authors: Spagnola Alan M. , Bennett Peter H. , Terasaki Paul I. 
Published: February 2007

AbstractVertebral ankylosing hyperostosis is a common skeletal disorder among Pima Indians. Prevalence rates of approximately 50% have been reported in Pima Indian males aged 55 or older. The HLA‐B27 antigen is also found more commonly in Pima Indians than in Caucasians (18% versus 6%). Because of the increased prevalence of both vertebral ankylosing hyperostosis and HLA‐B27 in Pima Indians, a possible association between the two was thought to exist. Therefore, histocompatibility testing was done on 44 adult male Pima Indians age 55 or older with classic vertebral ankylosing hyperostosis and 33 age‐matched controls. No significant association between any histocompatibility antigen phenotype or haplotype and vertebral ankylosing hyperostosis was found. This disease, therefore, cannot be classified with the HLA‐B27 associated spondylarthropathies.
Studies on heterophile antibodies in rheumatoid arthritis
Authors: Nishimaki Tomoe , Kano Kyoichi , Milgrom Felix 
Published: February 2007

AbstractSera and synovial fluids of patients with rheumatoid arthritis were studied for the presence of heterophile antibodies to sheep and bovine erythrocytes by means of hemolysis in agar gel. It was demonstrated that 18 of 146 sera had hemolytic antibody titers of 160 or more; all 18 (12%) against sheep and 8 (6%) against bovine erythrocytes. Of 31 synovial fluids examined, 5 showed hemolysin titers of 40 or more; all 5 (16%) against sheep and 3 (10%) against bovine erythrocytes. These heterophile antibodies were shown to belong to IgM and/or IgG class. Absorption and inhibition studies revealed that antibodies of 10 positive sera and 2 synovial fluids were of Forssman specificity and antibodies of 6 sera and 3 synovial fluids were of Hanganutziu‐Deicher specificity. Two remaining sera were shown to contain a mixture of Forssman antibodies and immune anti‐B antibodies.
Studies of immune functions of patients with systemic lupus erythematosus. i. dysfunction of suppressor t‐cell activity related to impaired generation of, rather than response to, suppressor cells
Authors: Sakane Tsuyoshi , Steinberg Alfred D. , Green Ira 
Published: February 2007

AbstractT cell suppressor function in patients with systemic lupus erythematosus (SLE) was evaluated by studying the ability of concanavalin A‐ (Con A) activated T cells to suppress proliferative responses by responder cells autologous with the Con A‐activated T cells. Impaired suppressor T‐cell activity in patients with SLE was observed with regard to three effector functions: 1) the allogeneic response of T cells, 2) the Con A response of T cells, and 3) the B cell response to pokeweed mitogen (PWM). No defect was found with regard to suppression of the T‐cell response to phytohemagglutinin (PHA).Mixing experiments between SLE and normal cells were carried out to further define the nature of the SLE suppressor defect. When responder cells from SLE patients were cultured with Con A‐activated T cells from normal controls, the normal suppressor T cells caused suppression of SLE responder cells. In contrast, Con A‐activated T cells from SLE patients were incapable of exerting suppressor effects on normal responder cells. These observations indicate that the impaired suppressor activity in SLE patients resides in the generation of suppressor T cells, rather than in the response to suppressor T cell signals.
Synovial fluid lactic acid. a diagnostic aid in septic arthritis
Authors: Brook Itzhak , Reza Michael J. , Bricknell Kenneth S. , Bluestone Rodney , Finegold Sydney M. 
Published: February 2007

AbstractLactic acid concentrations in the synovial fluid of 84 patients with acute monoarticular arthritis were determined by gas liquid chromatography. Lactic acid values in 27 cases of nongonococcal septic arthritis were strikingly higher (mean 1170 mg/100 ml) than in 45 cases of inflammatory or degenerative arthritis (mean 34 mg/100 ml), as well as in 12 cases of gonococcal arthritis (mean 27 mg/100 ml). With the proper equipment, determination of lactic acid can be a relatively rapid, reliable procedure. Synovial fluid lactic acid concentrations therefore can be used as a rapid, supplemental diagnostic aid in differentiating nongonococcal septic arthritis from both gonococcal and nonseptic acute arthritis.
Regional migratory osteoporosis. a denervation disease
Authors: Clay Mccord W. , Nies Kenneth M. , Campion David S. , Louie James S. 
Published: February 2007

AbstractRegional migratory osteoporosis is an uncommon entity characterized by sudden attacks of migrating lower extremity paraarticular pain, local edema, and muscle atrophy; the disease is verified by radiologic demineralization and bone scan uptake. The etiology and pathogenesis are unknown. We describe a case of regional migratory osteoporosis followed over nine years by serial electromyographic studies documenting denervation patterns coincident in time and location of each acute attack. The substantiation of denervation in regional migratory osteoporosis is of both diagnostic and pathogenetic significance.
Search for type‐c oncornavirus–related genetic information in tissues from patients with systemic lupus erythematosus
Authors: Aulakh Gurmit S. , Hicks John T. , John Martin W. , Phillips Paul E. 
Published: February 2007

AbstractSingle‐stranded 3H‐DNA probes complementary to the RNA of Rauscher murine leukemia virus and of simian sarcoma virus were prepared using techniques that permitted complete transcription of the viral genome of each virus. These probes were used in DNA‐DNA hybridization studies with the cellular DNA from uncultured specimens of spleens and placentas of patients with systemic lupus erythematosus (SLE). No proviral DNA sequences related to these viruses were detected in these tissues. The results presented here do not support previously reported antigenic data implicating type‐C oncornavirus infection of these organs in SLE.
High prevalence of hla‐cw1 and cw2 antigens in spondylarthritis
Authors: Kozin Franklin , Duquesnoy Rene , Rodey Glenn E. , Lightfoot Robert W. , Ryan Lawrence M. 
Published: February 2007

AbstractHLA‐B27 is frequently, but not invariably, found in patients with spondylarthritic diseases. Recently it has been shown that HLA‐C‐locus antigens w1 and w2 (w1/2) are in linkage disequilibrium with B27. A group of 139 patients with seronegative arthritis or spondylitis has been studied to determine the clinical and radiographic features associated with these antigens. An increased frequency of spondylarthritis was present in HLA‐B27‐negative, Cw1/2‐positive patients when compared with B27‐ and Cw1/2‐negative patients (P < 0.01). In addition, a large group of patients who did not fulfill accepted criteria for a specific spondylarthritic syndrome were identified; the frequency of both HLA‐B27 and Cw1/2 was greater in these individuals than in healthy blood donors. Thus HLA‐Cw1/2 are spondylitis‐associated antigens. These findings suggest that the critical genetic locus is neither B27 nor Cw1/2 but is a closely linked gene.
Effects of diphosphonates on glycosaminoglycan synthesis and proteoglycan aggregation in normal adult articular cartilage
Authors: Palmoski Marshall , Brandt Kenneth 
Published: February 2007

AbstractThe effects of disodium ethane‐1‐hydroxy‐1,1‐diphosphonate (EHDP) and disodium dichloromethylene diphosphonate (Cl2MDP) on glycosaminoglycan synthesis and macromolecular organization of proteoglycans have been examined in normal adult canine cartilage. One to 500 μM of either compound produced reversible inhibition of glycosaminoglycan synthesis to about 70% of control levels, whereas lower concentrations had no effect. Based on Sephadex G‐200 chromatography, the average hydro‐dynamic size of glycosaminoglycans in diphosphonate‐treated cartilage was similar to that of those in control cartilage. In most cases proteoglycan aggregates from diphosphonate‐treated cartilage were smaller in hydro‐dynamic size than those from control cartilage, as judged by Sepharose 2B elution profiles. The size of purified proteoglycan subunits, obtained after dissociation of the aggregates with 4 M guanidinium chloride or after incubation of the aggregates with hyaluronic acid β1 ← 3 hydrolase, was not affected by the diphosphonates. Furthermore, proteoglycans from diphosphonate‐treated cartilage did not interact in vitro with hyaluronic acid, suggesting that diminished proteoglycan aggregation may have resulted from an abnormality in the hyaluronate‐binding region of the proteoglycan core protein.
Reevaluation of the ammonium sulfate assay for dna antibody
Authors: Rubin Robert L. , Lafferty Joyce , Carr Ronald I. 
Published: February 2007

AbstractThe ammonium sulfate assay has recently come under criticism for alleged inability to detect low avidity antibody to DNA. The results of this study verify that a small percentage of antibody binding is not detected when this assay is performed under the conditions generally used. However, when the values obtained by the ammonium sulfate assay were compared to those obtained by other assays on sera of known avidity for DNA, it was concluded that ammonium sulfate does not selectively dissociate low avidity antibody from DNA. Conditions of incubation buffer and duration, pH, concentration of re‐actants, and molecular weight of the antigen are described for optimal detection of DNA antibody by the ammonium sulfate assay.
Demonstration of β1h globulin together with c3 in the dermal‐epidermal junction of patients with systemic lupus erythematosus
Authors: Carlo Jaime R. , Rothfield Naomi F. , Ruddy Shaun 
Published: February 2007

AbstractSkin lesions and clinically normal skin from 10 patients with systemic lupus erythematosus (SLE) were examined by immunofluorescence for the presence of C3 and its control protein, β1H globulin. β1H was always found in association with deposited C3; in the instance where C3 deposits were not found β1H was also not found. Granular deposits of C3 and β1H were found in the dermal‐epidermal junction (DEJ) in all of the 5 nonlesional skins studied. In the lesional skin, C3 was found in 4 of 5; in 2 of these 4, β1H was also found. As previously demonstrated for in vitro systems, β1H also binds in vivo to fragments of C3, presumably C3b, generated during activation of the complement system.
Survey for immune complexes in disseminated gonococcal arthritis‐dermatitis syndrome
Authors: Ludivico Charles L. , Myers Allen R. 
Published: February 2007

AbstractSeventeen patients with characteristic disseminated gonococcal arthritis‐dermatitis syndrome were studied for the presence of immune complexes, and circulating gonococcal antigen and antibody. The two immune complex techniques, monoclonal rheumatoid factor assay and cryoglobulin survey, did not reveal any consistent abnormalities. Complement levels (CH50, C″3, C″4) were not consistent with peripheral consumption except in 2 patients with coinciding systemic lupus erythematosus. Gonococcal antibody was detected in 47% of patients when they presented with the syndrome. However, gonococcal antigen was not found in either serum or synovial fluid. These results do not support the hypothesis that circulating immune complexes are involved in the pathogenesis of disseminated gonococcal arthritis‐dermatitis syndrome.
Lymphocytes from synovial tissue of a boy with x‐linked hypogammaglobulinemia and chronic polyarthritis
Authors: Abrahamsen Tore G. , Frøland Stig S. , Kåss Erik , Natvig Jacob B. , Pahle Jan 
Published: February 2007

AbstractLymphocytes were eluted from synovial tissue of a boy with X‐linked hypogammaglobulinemia and chronic polyarthritis. The cell suspension contained 53% lymphocytes and 28% peroxidase‐positive, macrophage‐like cells. No B lymphocytes, 83% T lymphocytes, and 10% Fc‐receptor‐bearing lymphocytes were detected. Lymphocyte transformation was induced by polyclonal mitogens (phytohemagglutinin and pokeweed mitogen) whereas no response to antigens (purified protein derivative and Candida albicans antigen) was obtained. The eluted cells displayed antibodydependent cytotoxicity.
Antibodies reacting with ribosomal ribonucleoprotein in connective tissue diseases
Authors: Miyachi Kiyomitsu , Tan Eng M. 
Published: February 2007

AbstractPrecipitating antibody to an antigen present in cytoplasm was detected in the sera of 7 patients with systemic lupus erythematosus, 1 patient with an overlap syndrome of systemic lupus erythematosus and rheumatoid arthritis, and 1 patient with mixed connective tissue disease. By physicochemical and enzymatic studies, the antigen was shown to have the properties of ribosomal ribonucleoprotein (r‐RNP). Cytoplasmic staining in immunofluorescence was observed with all the 9 sera containing antibodies to r‐RNP. In certain cases, cytoplasmic staining was associated with nucleolar staining. Antibody to r‐RNP is different in immunologic specificity and clinical significance from antibody to nuclear RNP and is present primarily in patients with systemic lupus erythematosus.