bluuebunny/crossref_metadata_2025_split huggingface dataset:
Heterogeneous dehalogenation of arylhalides in the presence of ionic liquids
Authors: Ohlin C. André , Béni Zolt´n , Laurenczy G´bor , Ruiz Nuria , Masdeu‐Bultó Anna M. 
Published: February 2007

AbstractDehydrohalogenation of haloaromatics in ionic liquids derived from ethylmethylimidazolium or similar salts has been performed using PdC, Pd(OAc)2 and other catalysts using formate salts as a hydrogen source. In the ionic liquid [emim][BF4], chlorobenzene was dehalogenated by up to 40%, bromobenzene up to 25% and iodobenzene up to 41% in 2 h. Reactions in the absence of the ionic liquid were also performed. Copyright © 2007 John Wiley & Sons, Ltd.
Synthesis, structure, and activity of (PhCH2NH2)2CuCl2 for oxidative coupling of 2‐naphthylamine
Authors: Zi Guofu , Xiang Li , Zhang Yadong , Wang Qiuwen , Zhang Zhanbin 
Published: February 2007

Abstract(PhCH2NH2)2CuCl2 (2), an effective oxidation reagent for oxidative coupling of 2‐naphthylamine (1) to form 2,2′‐diamino‐1,1′‐binaphthyl (4), is studied. Oxidative coupling of 2‐naphthylamine (1) is carried out at room temperature in methanol by (PhCH2NH2)2CuCl2 (2), which is prepared from CuCl2·2H2O and benzylamine in methanol, to give a novel copper complex, [{1,1′‐(C10H6)2‐2,2′‐(NH2)2}2CuCl]Cl·CH3OH·3H2O (3), in good yield. Treatment of 3 with aqueous HCl (37%), followed by addition of NH3·H2O (25%), gives 2,2′‐diamino‐1,1′‐binaphthyl (4) in a moderate yield (total yield from 1: > 70%). Both 2 and 3 have been characterized by various techniques, such as infrared spectroscopy, elemental analyses and X‐ray diffraction. Copyright © 2007 John Wiley & Sons, Ltd.
Where FoxP3‐dependent regulatory T cells impinge on the development of inflammatory arthritis
Authors: Nguyen Linh T. , Jacobs Jonathan , Mathis Diane , Benoist Christophe 
Published: February 2007

AbstractObjectiveRegulatory T cells play a suppressive role in many autoimmune diseases and can potentially affect various steps in the progression of disease. The purpose of this study was to analyze the role of Treg cells in the control of arthritis development.MethodsUsing crosses and cell transfers, we tested the effect of the scurfy loss‐of‐function mutation of the Foxp3 gene in the K/BxN mouse model. In this model, arthritis develops as the result of the production of high levels of pathogenic autoantibodies.ResultsThe absence of Treg cells in K/BxN mice led to faster and more aggressive arthritis. Strikingly, disease also spread to joints not normally affected in this model. The absence of Treg cells resulted in an acceleration of the immunologic phase of disease, with significantly earlier autoantibody production. However, the broadened spectrum of affected joints in Foxp3‐mutant mice was not due to the earlier appearance of autoantibodies and could not be reproduced by increasing the anti–glucose‐6‐phosphate isomerase antibody load, which demonstrates an impact of Treg cells on effector phase manifestations. In addition, FoxP3+,CD25+ Treg cells accumulated in inflamed joints, even in nontransgenic animals. This preferential localization mimics that in human arthritides and indicates a preferential homing/retention of Treg cells to sites of inflammation.ConclusionThese results indicate that Treg cells play a role in antibody‐mediated arthritis at several levels. Treg cells are involved in constraining the immune phase of disease, as well as limiting the articular damage provoked by the pathogenic autoantibodies in terms of severity and of the range of affected joints, which may contribute to the limited distal predominance of many arthritides.
Vaccination with selected synovial T cells in rheumatoid arthritis
Authors: Chen Guangjie , Li Ningli , Zang Ying C. Q. , Zhang Dongqing , He Dongyi , Feng Guozhang , Ni Liqing , Xu Rong , Wang Li , Shen Baihua , Zhang Jingwu Z. 
Published: February 2007

AbstractObjectiveThis pilot clinical study was undertaken to investigate the role of T cell vaccination in the induction of regulatory immune responses in patients with rheumatoid arthritis (RA).MethodsAutologous synovial T cells were selected for pathologic relevance, rendered inactive by irradiation, and used for vaccination. Fifteen patients received T cell vaccination via 6 subcutaneous inoculations over a period of 12 months.ResultsT cell vaccination led to induction of CD4+ Tregs and CD8+ cytotoxic T cells specific for T cell vaccine. There was selective expansion of CD4+,Vβ2+ Tregs that produced interleukin‐10 (IL‐10) and expressed a high level of transcription factor Foxp3, which coincided with depletion of overexpressed BV14+ T cells in treated patients. CD4+ IL‐10–secreting Tregs induced by T cell vaccination were found to react specifically with peptides derived from IL‐2 receptor α‐chain. The expression level of Foxp3 in CD4+ T cells and increased inhibitory activity of CD4+,CD25+ Tregs were significantly elevated following T cell vaccination. The observed regulatory immune responses collectively correlated with clinical improvement in treated patients. In an intent‐to‐treat analysis, a substantial response, defined as meeting the American College of Rheumatology 50% improvement criteria, was shown in 10 of the 15 patients (66.7%) and was accompanied by a marked improvement in RA‐related laboratory parameters.ConclusionThese findings suggest that T cell vaccination induces regulatory immune responses that are associated with improved clinical and laboratory variables in RA patients.
Suppression of immune responses in collagen‐induced arthritis by a rationally designed CD80‐binding peptide agent
Authors: Srinivasan Mythily , Eri Rajaraman , Zunt Susan L. , Summerlin Don‐John , Brand David D. , Blum Janice S. 
Published: February 2007

AbstractObjectiveThe CD80/CD86–CD28/CD152 costimulatory pathways transmit signals for CD4+ T cell activation and suppression and are critically involved in the pathogenesis of rheumatoid arthritis (RA). A significant number of CD4+ T cells and macrophages in the rheumatoid synovium express elevated levels of CD80, increasing the potential for costimulation in trans of naive T cells. To determine the effect of blockade of this costimulatory axis in RA, we designed novel CD80‐binding peptides and evaluated their therapeutic potential in collagen‐induced arthritis (CIA), an animal model of RA.MethodsThe conserved MYPPPY motif of CD152 adopts a polyproline type II (PPII) helical conformation in the CD80–CD152 complex. The pairing preferences of the critical residues at the CD80–CD152 interface and their propensity to form PPII helices were integrated to design peptides with optimum PPII helical content that selectively block CD80–receptor interactions. The clinical efficacy was tested in DBA/1LacJ mice that were administered the CD80 blocking agents, called CD80‐binding competitive antagonist peptides (CD80‐CAPs), at the time of immunization with bovine type II collagen or 3 weeks after immunization.ResultsA single administration of select CD80‐CAPs significantly reduced the clinical, radiologic, and histologic disease severity in CIA. Importantly, administration of CD80‐CAPs during activated immune response significantly suppressed disease development by reducing mononuclear cell infiltration in the joints and mediating peripheral deletion of activated CD4+ T cells.ConclusionA rationally designed CD80‐binding peptide both prevents and suppresses CIA, suggesting a potential application in RA. Apoptosis of activated CD4+ T cells following in vivo blockade suggests that the effects of CD80‐CAPs may be long‐lasting.
Prevalence, risk factors, and outcome of uveitis in juvenile idiopathic arthritis: A long‐term followup study
Authors: Saurenmann R. K. , Levin A. V. , Feldman B. M. , Rose J. B. , Laxer R. M. , Schneider R. , Silverman E. D. 
Published: February 2007

AbstractObjectiveTo assess the prevalence, risk factors, and long‐term outcome of uveitis in patients with juvenile idiopathic arthritis (JIA).MethodsAn inception cohort of all 1,081 patients diagnosed as having JIA at a single tertiary care center was established. A questionnaire and followup telephone calls were used to confirm the diagnosis of uveitis. Ophthalmologists' records of patients with uveitis were collected. Kaplan‐Meier and Cox regression analyses were used to assess risk factors for developing uveitis and for complications of uveitis.ResultsAfter a mean followup time of 6.9 years, 142 of 1,081 patients (13.1%) had developed uveitis. Risk factors were young age at diagnosis, female sex, antinuclear antibody positivity, and the subtype of JIA. The relative contribution of these risk factors was different for the different subtypes of JIA. Until the end of the study, uveitis complications had developed in 53 of 142 patients with uveitis (37.3%; 4.9% of the total cohort). Only 16 of 175 involved eyes (9.1%) in 14 of 108 patients (13%; 1.3% of the total cohort) for whom ophthalmology reports were available had best corrected visual acuity less than 20/40 (mean followup time for uveitis of 6.3 years). Abnormal vision was associated with synechiae or cataract.ConclusionRisk factors for developing uveitis were different among subtypes of JIA. The long‐term outcome of JIA‐associated uveitis in our cohort was excellent despite the high rate of complications.
First report of macrophage activation syndrome in hyperimmunoglobulinemia D with periodic fever syndrome
Authors: Rigante Donato , Capoluongo Ettore , Bertoni Barbara , Ansuini Valentina , Chiaretti Antonio , Piastra Marco , Pulitanò Silvia , Genovese Orazio , Compagnone Adele , Stabile Achille 
Published: February 2007

AbstractWe describe for the first time a case of macrophage activation syndrome in a child with hyperimmunoglobulinemia D with periodic fever syndrome who required intensive care support. Up‐regulated monokine production, high serum levels of triglycerides and ferritin, clotting abnormalities with hypofibrinogenemia, and rapidly evolving pancytopenia should alert the clinician to the possible diagnosis of macrophage activation syndrome, even in autoinflammatory diseases characterized basically by the periodic recurrence of unprovoked inflammatory attacks. Bone marrow aspiration showing well‐differentiated macrophages phagocytosing hematopoietic elements remains the main tool for a final diagnosis, and cyclosporine is the best strategy for treatment.
Mesenteric transection decreases expression of interstitial cells of Cajal in an experimental model
Authors: Nishimura M , Koda K , Oda K , Seike K , Shimizu K , Miyazaki M 
Published: February 2007

Abstract

Background
After anterior resection for rectal carcinoma patients often complain of defaecatory dysfunction. The aim of this study was to examine the number of interstitial cells of Cajal (ICCs) and ganglion cells in the distal colon partially denervated by mesenteric transection in a rat model.

Methods
Four groups of rats were operated on, a control group and three experimental groups, with increasing degree of mesenteric transection to denervate the distal colon. Animals were killed after 3 months, and the denervated colon was investigated using immunohistochemistry with Kit and protein gene product 9.5 antibodies to detect ICCs and ganglion cells respectively. Reverse transcriptase–polymerase chain reaction for c-kit and histomorphometry of muscular thickness were performed.

Results
The total number of ICCs was significantly lower in the three operated models than in the control, particularly in the histological layers of the myenteric plexus and submucosal border. There was no difference in the number of ganglion cells or changes in muscular thickness between the models.

Conclusion
The number of ICCs in rat distal colon denervated by mesenteric transection is decreased at 3 months after surgery.
Synthesis, Structure, and Properties of the High‐Pressure Modification of CePdSn — A 5 K Antiferromagnet.
Authors: Heymann Gunter , Riecken Jan F. , Rayaprol Subhindra , Christian Sandra , Poettgen Rainer , Huppertz Hubert 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Molecular Simulation Studies of Water Physisorption in Zeolite.
Authors: Di Lella Angela , Desbiens Nicolas , Boutin Anne , Demachy Isabelle , Ungerer Philippe , Bellat Jean‐Pierre , Fuchs Alain H. 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Mixed‐Valent Selenidoantimonates(III,V) with Transition‐Metal Complexes as Counterions: Solvothermal Syntheses and Characterization of [M(dien)2]2Sb4Se9 (M: Mn, Fe), [Co(dien)2]2Sb2Se6, and [Ni(dien)2]2Sb2Se5.
Authors: Jia Dingxian , Zhang Yong , Zhao Qianxin , Deng Jie 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
(C5H14N2) [Zn3(HPO4)4], a New 3D Open‐Framework Zincophosphate Synthesized by Hydrothermal Reversible Transformation of (C5H14N2) [Zn2(HPO4)3]×H2O.
Authors: Wiebcke Michael 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Na3TbSi3O9×3H2O: A New Luminescent Microporous Terbium(III) Silicate Containing Helical Sechser Silicate Chains and 9‐Ring Channels.
Authors: Wang Guangmei , Li Jiyang , Yu Jihong , Chen Peng , Pan Qinhe , Song Hongwei , Xu Ruren 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
CsLn(Ln6CoI12)2 (Ln: Gd, Er) and (CeI)0.26(Ce6MnI9)2: Two New Structure Types Featuring Ln6Z Clusters.
Authors: Sweet Lucas E. , Hughbanks Timothy 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Reactions of Methyl 2‐(Benzyloxycarbonyl)amino‐3‐dimethylaminopropenoate and Related Compounds with Hydrazines. Regiospecific Synthesis of 1‐Substituted‐4‐amino‐substituted‐1H‐pyrazol‐5‐(2H)‐ones.
Authors: Sorsak Lucija Jukic , Sorsak Gorazd , Toplak Renata , Bevk David , Svete Jurij , Stanovnik Branko 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Mild and Convenient Method for Reduction of Carbonyl Compounds with the NaBH4/Charcoal System in Wet THF.
Authors: Setamdideh Davood , Zeynizadeh Behzad 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Direct Electrophilic α‐Fluorination of Imines: Efficient Synthesis of Mono‐ and Difluoroimines.
Authors: Verniest Guido , Van Hende Eva , Surmont Riccardo , De Kimpe Norbert 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Amination of 1,3‐Dihalo‐2‐nitrosobenzenes.
Authors: Gornostaev L. M. , Bocharova E. A. , Geets N. V. 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Ionic Liquid‐Assisted Synthesis of Trinitroethyl Esters.
Authors: Sheremetev Aleksei B. , Yudin Igor L. , Suponitsky Kirill Yu. 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Palladium—Tetraphosphine as Catalyst Precursor for High‐Turnover‐Number Negishi Cross‐Coupling of Alkyl‐ or Phenylzinc Derivatives with Aryl Bromides.
Authors: Kondolff Isabelle , Doucet Henri , Santelli Maurice 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
π‐Allylic C1‐Substitution in Water with Nitromethane Using Amphiphilic Resin‐Supported Palladium Complexes.
Authors: Uozumi Yasuhiro , Suzuka Toshimasa 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Divalent Activation in Temporary Phosphate Tethers: Highly Selective Cuprate Displacement Reactions.
Authors: Whitehead Alan , McParland James P. , Hanson Paul R. 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Stereoselective Titanium‐Mediated Aldol Reactions of (S)‐2‐tert‐Butyldimethylsilyloxy‐3‐pentanone.
Authors: Nebot Joaquim , Figueras Sergi , Romea Pedro , Urpi Felix , Ji Yining 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of 3‐Isothiocyanatopropion‐ and ‐butyraldehyde Diethyl Acetals and Their Reactions with N‐Nucleophiles.
Authors: Fisyuk A. S. , Mukanov A. Yu. 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Generation of Cyclopropanediazonium and Its Chemical Transformations in the Presence of Phenol.
Authors: Klimenko I. P. , Korolev V. A. , Tomilov Yu. V. , Nefedov O. M. 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Pd(OAc)2/DABCO‐Catalyzed Suzuki—Miyaura Cross‐Coupling Reaction in DMF.
Authors: Li Jin‐Heng , Zhu Qi‐Ming , Xie Ye‐Xiang 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis and Application of Quinazoline—Oxazoline‐Containing (Quinazox) Ligands.
Authors: Fekner Tomasz , Mueller‐Bunz Helge , Guiry Patrick J. 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Degenerate Rearrangement of 9‐Isopropenyl‐9,10‐dimethylphenanthren‐9‐yl and 9,10‐Dimethyl‐9‐(trans‐1‐methylprop‐1‐en‐1‐yl)phenanthren‐9‐yl Cations.
Authors: Artamoshkin V. G. , Bushmelev V. A. , Genaev A. M. , Shubin V. G. 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
An Optically‐Active Liquid‐Crystalline Hexa‐Adduct of [60]Fullerene which Displays Supramolecular Helical Organization.
Authors: Campidelli Stephane , Brandmueller Torsten , Hirsch Andreas , Saez Isabel M. , Goodby John W. , Deschenaux Robert 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
New Route to Azaspirocycles via the Organolithium‐Mediated Conversion of β‐Alkoxy Aziridines into Cyclopentenyl Amines.
Authors: Moore Stephen P. , Coote Susannah C. , O'Brien Peter , Gilday John 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
An Environmentally Benign Catalytic System for Alkene Epoxidation with Hydrogen Peroxide Electrogenerated in situ.
Authors: Ho Kam‐Piu , Chan Tak Hang , Wong Kwok‐Yin 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Lipase‐Mediate Epoxidation Utilizing Urea—Hydrogen Peroxide in Ethyl Acetate.
Authors: Ankudey Emanuel G. , Olivo Horacio F. , Peeples Tonya L. 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of α,β‐Unsaturated γ‐Lactones via Photooxygenation of 2,3‐Dihydrofurans Followed by Ferrous Ion Catalyzed gem‐Dehydration.
Authors: Chen Yu‐Zhe , Wu Li‐Zhu , Peng Ming‐Li , Zhang Dong , Zhang Li‐Ping , Tung Chen‐Ho 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Highly Diastereoselective Approach to Tetrahydrofurans via [3 + 2] Cycloadditions of Silylmethyl‐Substituted Cyclopropanes with Aldehydes and Ketones.
Authors: Gupta Archana , Yadav Veejendra K. 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Intramolecular Thia‐anti‐Michael Addition of a Sulfur Anion to Enones: A Regiospecific Approach to Multisubstituted Thiophene Derivatives.
Authors: Li Yan , Liang Fushun , Bi Xihe , Liu Qun 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Syntheses and Structures of Novel Heteroarene‐Fused Coplanar π‐Conjugated Chromophores.
Authors: Wong Ken‐Tsung , Chao Teng‐Chih , Chi Liang‐Chen , Chu Ying‐Ying , Balaiah Akula , Chiu Shih‐Feng , Liu Yi‐Hung , Wang Yu 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Metal‐Free Approach to the Synthesis of Indoline Derivatives by a Phenyliodine(III) Bis(trifluoroacetate)‐Mediated Amidohydroxylation Reaction.
Authors: Correa Arkaitz , Tellitu Imanol , Dominguez Esther , SanMartin Raul 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.