bluuebunny/crossref_metadata_2025_split huggingface dataset:
HISTOPATHOLOGICAL FEATURES OF MICE LIVER AND KIDNEY ON ORAL ACUTE TESTING OF WHITE RADISH TUBER LYOPHILISATE
Authors: Wahyuddin Nurzadrina , Utami Yuri Pratiwi , Rahman Noer Fauziah , Nodjeng Andi Rainun Puspa , Marewa Kezya Ratu 
Published: March 2024

Background and aim: Radish tuber (Raphanus sativus L.) is one of the plant species often consumed by society as a vegetable. Currently, its use is beginning to expand as a medicinal plant, including its use for diabetes, pharyngitis, sinusitis, cardiac fibrosis, diuretics, and bacterial infections. This study aims to determine the histopathology of the liver and kidney organs in male albino mice (Mus musculus) by testing the oral pungency of white radish (Raphanus sativus L.).
Methods: This experimental study used 12 mice weighing 25–30 grams, divided into 4 treatment groups: Group 1 was administered aquadest, Group 2 received a dose of 400 mg, Group 3 received 800 mg, and Group 4 received 1600 mg of the medication. The treatment was carried out for 14 days, and then the mice were euthanized to see the histopathology of the hepatic and kidney tissues.
Results: In the histopathology of the liver and kidney in treatment groups 1, 2, 3, and 4, the results were normal, mild, moderate, and severe damage, respectively. In kidney histopathology, there are signs of damaged tissue, such as bleeding, edema, and inflamation cells.
Conclusion: It can be concluded that the higher the dose of white radish lyophilizate, the greater the potential to cause toxicity to the liver and kidney organs.

Peer Review History:
Received 3 December 2023; Revised 29 January 2024; Accepted 27 February; Available online 15 March 2024
Academic Editor: Prof. Dr. Gorkem Dulger, Duzce University, Turkey, gorkemdulger@yandex.com
Average Peer review marks at initial stage: 6.0/10
Average Peer review marks at publication stage: 8.0/10
Reviewers:
Prof. Hassan A.H. Al-Shamahy, Sana'a University, Yemen, shmahe@yemen.net.ye
Dr. George Zhu, Tehran University of Medical Sciences, Tehran, Iran, sansan4240732@163.com
A REVIEW: OPUNTIA FICUS-INDICA AS A SOURCE OF BIOACTIVE COMPOUND INGREDIENTS FOR FUNCTIONAL FOODS, NUTRITION, HUMAN DISEASE AND HEALTH
Authors: Ahmed Fatma A. , Ibrahim Marwa A. , El-Azab Mayada M. , Fahmy Waleed G E , Fahmy Dina M. 
Published: March 2024

Originally from Mexico, today, prickly pears (Opuntia ficus-indica (L.) Mill.) can be found worldwide, but they are most common in Africa., Australia, and the countries of the Mediterranean. The Cactaceae family, which has more than 1500 species of cactus, includes prickly pears. Additionally, consumers are becoming more and more interested in it because it contains bioactive substances like carotenoids, sterols, polyunsaturated fatty acids, polyphenols, and vitamins that are linked to important biological and functional activities such as effects on antioxidants, inflammation, and hypoglycemia as it prospers in dry and semiarid areas, this plant is very effective in preventing desertification and can be exploited in fields and gardens as a fence. Although it is frequently used today to make culinary products like jams and juices, it is also eaten as a fruit. If one wishes to create novel products with health-promoting properties for food, cosmetics, or pharmaceutical fields, As a feasible wellspring of phytochemicals for practical food sources, natural additions, or nutritional supplements, prickly pears are affordable.

Peer Review History:
Received 3 December 2023; Revised 25 January 2024; Accepted 6 March; Available online 15 March 2024
Academic Editor: Dr. Sally A. El-Zahaby, Pharos University in Alexandria, Egypt, sally.elzahaby@yahoo.com
Average Peer review marks at initial stage: 6.0/10
Average Peer review marks at publication stage: 7.0/10
Reviewers:
Dr. Gehan Fawzy Abdel Raoof Kandeel, Pharmacognosy Department, National Research Centre, Dokki, 12622, Giza, Egypt, gehankandeel9@yahoo.com
Dr. Evren Alğin Yapar, Turkish Medicines and Medical Devices Agency, Turkiye, evren.yapar@yahoo.com
TARGET ONCOGENIC RECEPTORS IN TUMOURS, FROM ITS INITIAL CLINICAL BREAKTHROUGHS TO CURRENT CLINICAL STANDARD THERAPY
Authors: Zhu George 
Published: March 2024

Epidermal growth factor (EGF) is a polypeptide hormone originally isolated from mouse submaxillary gland, which is a potent mitogen for a wide variety of culture cells of both epithelial and mesenchymal origin, and its important role in the proliferation, differentiation, and survival of neural and glial precursor cells. The physiological effects of EGF are mediated by an EGF receptor with tyrosine-specific protein kinase activity. The traditionally accepted view is that normal epidermal growth factor receptor (EGFR) is no tumorigenic, whereas mutated EGFR such as an oncogenic receptor EGFRvIII is oncogenic. In recent, it has been implicated that EGF could be beneficial for burn, wound healing, diabetic foot ulcer, and show an attractive perspective. In addition, cosmetic containing EGF would be effective in improving the plasticity of skin, helps in anti-aging and whitening, and controls the amount of erythema and sebum in the skin. In our team we have successfully prepared a series of 350 bottles of Shampoo liquid and 26 bottles of recombinant human EGF (rhEGF) spray, and 4 bottles of EGF-Silvadence ointment. The initial results indicated that prepared rhEGF is safe and available in clinical use. On the other hand, progress on the interaction of EGF with its altered oncogenic receptor signaling through its downstream molecules such Ras/Raf/MAPK (see figure in the full text, George Zhu,1991) and/or PI3k/akt pathway in the development of some cancers such as A431 human epidermoid carcinoma cells, brain glioblastoma, breast, pancreas and lung cancers. In addition to a series of gefitinib, erlotinib, osimertinib and the CIMA vax-EGF vaccine, an antioncogenic receptor antibody based fusion protein [for example Cetuximab-based IL-10 fusion protein, CmAb-(IL10)2] provide a potential strategy to improve cancer immunotherapy.

Peer Review History:
Received 1 December 2023; Revised 26 January 2024; Accepted 2 March; Available online 15 March 2024
Academic Editor: Dr. Tamer Elhabibi, Suez Canal University, Egypt, tamer_hassan@pharm.suez.edu.eg
Average Peer review marks at initial stage: 6.0/10
Average Peer review marks at publication stage: 8.0/10
Reviewers:
Dr. Bilge Ahsen KARA, Ankara Gazi Mustafa Kemal Hospital, Turkey, ahsndkyc@gmail.com
Dr. Asia Selman Abdullah, University of Basrah, Iraq, asia_abdullah65@yahoo.com
Correlation and Path Analysis for Yield and Yield Component Traits on Bread Wheat (Triticum aestivum L.) Genotypes
Authors: Zewdu Demeke , Mekonnen Fikru , Geleta Negash 
Published: March 2024

The research was conducted at Kulumsa Agricultural Research Center Main Station, during July–November, 2021 (Main cropping season) to study the association among traits and estimate the direct and indirect effects of various traits on grain yield of bread wheat genotypes. A total of 64 bread wheat genotypes were evaluated for 16 traits in 8×8 simple lattice design. Grain yields showed positive and highly significant at (p<0.01) genotypic and phenotypic correlation with plant height, number of seeds spike-1, head weight, yield head-1, biomass yield, hectoliter weight, test weight and harvest index. Genotypic correlation coefficients were greater for all significantly correlated with grain yield studied traits than the corresponding phenotypic correlation coefficients, indicating inherent association of the characters, therefore, selection for these characters could improve grain yield. Genotypic path analysis of the direct effects revealed that days to maturity, number of spikelets spike-1, head weight, yield head-1, biomass yield, hectoliter weight, test weight and harvest index exerted direct positive effect on grain yield. Phenotypic path analysis of the direct effects showed that days to maturity, plant height, number of tillers plant-1, number of seeds spike-1, head height, yield head-1, biomass yield, test weight and harvest index had direct positive effect on grain yield. Therefore, these traits should be considered for bread wheat breeding program for yield improvement.
KREATIVITAS GURU PENGERAK MENUJU PENGUATAN PROFIL PELAJAR PANCASILA
Authors: Nari Nola 
Published: March 2024

Problems teacher creativity becomes focus necessary problem searched Street out and have becomes problem classics of the world of education. One of them implementation curriculum independent through creative driving teachers as means strengthening profile Pancasila students. Destination study this is for dig forms creativity that can driving teacher emerged through the driving teacher program and the teaching module as a teacher means strengthening profile Pancasila students. Study this use approach qualitative. Informant study chosen with technique purposive sampling. The data collection process is carried out with interview deep, study documentation and notes field . Data analysis was performed with refer to the Miles and Huberman model. For ensure the validity of the researcher 's data use technique triangulation and upgrade perseverance researcher in analyze document found. Research results show that forms driving teacher creativity is creativity personal form desire for move to do change, creativity process with follow training and creativity product through development teaching module as well creativity form encouragement good from personal or environment as well as government. The creativity of driving teachers will produce strengthening profile Pancasila students
ANALISIS DAN PERANCANGAN SISTEM PICK-UP BARANG MENGGUNAKAN METODE ICONIX PROCESS
Authors: Rismawati Sinta Ayu , Eka Putri Siti Oktavia , Ramadhani Nasywa Zahira , Ana Wati Seftin Fitri , Fitri Anindo Saka 
Published: March 2024

CV. Kreasi Wisata adalah sebuah organisasi yang bergerak di bidang logistik sekaligus penyedia jasa kurir yang bekerja sama dengan PT. Lion Parcel Express. CV. Kreasi Wisata ternyata masih menggunakan metode yang kurang efektif pada proses bisnisnya, seperti penyampaian informasi pick-up lewat chat pribadi ke admin lalu diteruskan ke kurir tanpa penjadwalan yang terbilang kurang efektif. Oleh karena itu, perlu adanya sebuah sistem baru yang dapat memudahkan para aktor (Customer, Admin, dan Kurir) selama proses pick-up barang. Dalam artikel ini dibahas mengenai analisis dan perancangan sistem pick-up barang dengan menggunakan iconix process. Pengumpulan data dilakukan dengan metode observasi dan wawancara langsung ke pihak yang bersangkutan, ditambah dengan literature review dari jurnal yang berkaitan. Perancangan sistem yang diusulkan digambarkan dengan UML (Unified Modelling Language). Hasil dari analisis dan perancangan ini berupa desain sistem informasi yang dapat melakukan penjadwalan pick-up barang dari order yang dilakukan customer secara otomatis dan dilengkapi dengan fitur tracking. Untuk selanjutnya, diharapkan sistem ini dapat dilanjutkan ke tahap pengembangan dan diimplementasikan pada CV. Kreasi Wisata.
ANALISIS KETERSEDIAAN INFRASTRUKTUR DAN AKSEBILITAS DI RSUP Dr. Rivai Abdullah
Authors: Rahmawati Zaura Dwi 
Published: March 2024

Abstrak: Penelitian ini bertujuan untuk menganalisis ketersediaan infrastruktur teknologi informasi dan aksesibilitas di RSUP Dr. Rivai Abdullah. Metode yang digunakan adalah survei dan pengumpulan data melalui observasi langsung serta wawancara oleh peneliti dengan pihak dari rumah sakit. Hasil penelitian menunjukkan bahwa RSUP Dr. Rivai Abdullah memiliki infrastruktur yang memadai, termasuk ruang operasi, ruang rawat inap, dan fasilitas penunjang lainnya. Namun, terdapat beberapa kendala yaitu kesulitan dalam penggunaan salah satu aplikasi yang membantu proses dirumah sakit karena belum terbiasanya menggunakan aplikasi tersebut, bahasa aplikasi yang berat dan beberapa faktor lainnya. Terkait aksesibilitas, seperti keterbatasan parkir dan kekurangan akses untuk penyandang disabilitas. Berdasarkan temuan ini, disarankan agar RSUP Dr. Rivai Abdullah dapat menemukan cara agar dapat mengatasi kesulitan dalam penggunaan aplikasi tersebut dan meningkatkan fasilitas parkir dan memperhatikan aksesibilitas bagi penyandang disabilitas guna meningkatkan pelayanan kepada pasien. Kata kunci: Infrastruktur Teknologi Informasi, Aksesibilitas, Analisis, RSUP Dr. Rivai Abdullah.
Using eScriptorium to work on documents: eScriptorium applied on a 13th century French cartulary
Authors: Galli Michela 
Published: March 2024

As part of the research on Digital Diplomatics or on new tools usable in Diplomatics’ studies, this essay discusses the experience of treating a 13th century French cartulary with eScriptorium. By analyzing the functioning of this open-source software created mainly for the automatic transcription of any type of document, in any language and on any medium, we will see step by step its application on the the Saint-Etienne-des-Grès church’s cartulary. If the starting hypothesis proposed the software’s use for the analysis of both internal and external features on the one hand and on the other the experimentation of several HTR models on a document tipology which by nature can include a great variety of different scripts, such as in this case, the work proved satisfactory for the recognition of the external features of the document and a good result was achieved in terms of automatic transcription. As far as the analysis of the internal features is concerned, it is currently not possible to carry it out directly on the software. ​​​​​​​By the way, at this stage the work one does on eScriptorium can be exported and then transformed into TEI, taking into account that the eScriptorium team is working on the integration of the TEI’s principles into the tool, promising good results in the near future.
Energy-Related Hormones in Raw and Retail Cow’s Milk and Possible Risk for Consumers
Authors: Knežević Dragan , Bošnjaković Dušan , Dražić Slavica , Nedić Sreten , Vujanac Ivan , Valčić Olivera , Pantelić Marija , Stojiljković Mojca , Sladojević Željko , Kirovski Danijela 
Published: March 2024

Abstract
The study aimed to determine the concentration of energy-related hormones in cow’s milk and to consider them from a public health perspective. Fourteen Holstein cows were subjected to milk and blood sampling on the following days in lactation (DIL): 10, 30, 60, 90, 150, 180, 210, 250 and 280 to determine milk hormones, fat and protein content and blood biochemical parameters. For the same purpose, bulk-tank milk was sampled and samples of retail m ilk with 1.5% (CM1.5) and 3.2% (CM3.2) fat was purchased. Milk insulin-like growth factor-1 (IGF-1) values were significantly lower at 90, 150, 180, 210 and 250 and significantly higher at 10, 30 and 60 DIL than lactation average (LA). Milk insulin concentrations were significantly lower at 30, 60 and 90 and higher at 210, 250 and 280 DIL than LA. Free thyroxine (fT4) level in the milk was higher at 250 DIL, while milk free triiodothyronine (fT3) concentrations were lower at 30, 60, 90 and 280 DIL, and significantly higher at 10 and 180 DIL than respective LA. Milk cortisol levels were lower at 60 and 280 DIL than LA. All measured milk hormones were significantly lower in CM1.5 compared to CM3.2, bulk-tank milk and LA. An exception was the LA of IGF-1, which was significantly lower than the IGF-1 content in CM1.5. Blood biochemical parameters fluctuated evenly during lactation and were within the reference range. Hormone concentrations in cow’s milk fluctuate during lactation, giving milk an important role in the context of public health.
Influence of Frequent Phlebothomy on Blood Iron Concentration, Haematological, Metabolic and Endocrine Parameters in Rams
Authors: Grubač Siniša , Cincović Marko , Radinović Miodrag , Potkonjak Aleksandar , Žekić Marina , Starič Jože , Prodanov Radulović Jasna 
Published: March 2024

Abstract
Frequent phlebotomies, even when only a small volume of blood is taken for diagnostic purposes, can lead to the development of iron deficiency with hematological and metabolic changes. The study aimed to determine the influence of frequent blood loss by phlebotomy on blood iron concentration (Fe), hematology, metabolic and endocrine parameters and their relationships. Blood samples were collected from 30 blood donor rams for 6 consecutive weeks, with approximately 10% of blood collected weekly. Such chronic blood loss resulted in a decrease in Fe. Indicators of iron transport in the bloodstream changed, so the value of total iron-binding capacity (TIBC) and unsaturated iron-binding capacity (UIBC) increased, while the value of transferrin saturation percentage (TS%) decreased. Hematological changes included a decrease in red blood cells, hemoglobin, mean red blood cell volume and hematocrit and a tendency for reticulocyte count and red cell distribution width to increase. Chronic blood loss resulted in a specific metabolic response that included the increase in glucose, cholesterol, triglycerides, aspartate-aminotransferase, and insulin resistance, while thyroxine, triiodothyronine and cortisol decreased and there was a tendency for lactate to increase and BHB to decrease. The mentioned blood parameters correlated with Fe and additionally showed greater changes when Fe was extrapolated to the level of clinical deficit (Fe=9μmol/L). These correlations suggest the need to monitor the metabolic and endocrine status during chronic blood loss, in addition to Fe and erythrocyte indices. Compared with previous results in other animal species, Fe may have a direct influence on metabolic processes in rams.
Impact of Arsenic on Mouse Ovaries Over Three Generations
Authors: Birinji Anita , Lalošević Dušan , Mihaljev Željko , Pogrmić-Majkić Kristina , Radovanović Anita , Glišić Radmila , Marin Marija 
Published: March 2024

Abstract
This study aimed to measure the total arsenic content deposited in the ovaries of three consecutive generations of mice. The animals were treated with two different concentrations to determine whether histological changes were caused in the ovaries. The control group of mice received tap water, whereas the experimental groups were given different concentrations of dissolved arsenic (III)-oxide. The arsenic content in the ovaries in both experimental groups increased with each generation. The highest content was recorded in the third generation of the second experimental group. Between the two experimental groups in each generation, significant differences in the average number of corpora lutea and ovarian follicles were identified. Arsenic caused structural changes in the ovaries in both experimental groups in all three consecutive generations.
Epigenetic Investigation Related to Gastrointestinal Helminth Resistance and Performance in Cattle
Authors: de Almeida Cipriano Isabela , de Favare Giordani Mascoli , do Carmo Tábata Alves , Mena Mateus Oliveira , Vicari Daniel Vitor Ferreira , Pagnozzi Fernanda Calazans , Pacheco Tiago Marolato , Rodrigues Maria Gabriela Fontanetti , Pavan Bruno Ettore , de Soutello Ricardo Velludo Gomes 
Published: March 2024

Abstract
The objective was to characterize a herd of 73 Nellore heifers, identifying resistant, resilient, and susceptible animals to gastrointestinal helminths, relating the global methylation of the DNA of these animals with the degree of helminthiasis and factors that interfere with performance. Individual count of eggs per gram of feces (EPG), fecal culture for gender identification, weighing and blood sampling were carried out to determine PCV, STP, EOS, IgG, followed by DNA extraction and methylation analysis. The results were: 47% resistant animals, 34% resilient, and 19% susceptible to gastrointestinal helminth infections, with EPG counts of 53, 216, and 841, respectively, showing a statistical difference between all groups. The quantification of DNA methylation was 0.311, 0.245 and 0.178, respectively, for resistant, resilient, and susceptible animals, with a correlation being found between resistance to gastrointestinal helminths and overall DNA methylation. For weight gain, resistant and resilient animals showed higher values than susceptible ones, with a correlation between weight gain and EPG. The same was observed for VG; however, there was no statistical difference to the EOS, PPT, and IgG values. A significant correlation was found between PCV and EPG; quantifications of PCV and methylated DNA, STP and EPG; VG and STP. Therefore, the methodologies used made it possible to identify the animals regarding the degree of infection by gastrointestinal nematodes, making it possible to correlate the resistance of cattle to helminths with the amount of global DNA methylation and its performance.
Enterobacteria Isolated From Diarrheic Calves and their Phenotypic Resistance Pattern
Authors: Trindade Gonçalves Lucilene Martins , Santos Caroline Lima , Policarpo Wendel Adelino , de Melo Santana Lisa Hauane , Medeiros de Oliveira Kely Janine , Bezerra Ana Catarina Pinheiro Angelim , Ribeiro Sousa Jaize Viana , Araújo Piancó Luísa , Silva Diego Marques Costa , Veiga de Sousa Leandro Henrique , de Oliveira Santos Giselle Cutrim , Barroso de Carvalho Robert Ferreira , Azevedo Carvalho Isabel , Pereira Santos Hamilton , de Moraes Pereira Helder 
Published: March 2024

Abstract
Diarrhea is a prevalent and economically impactful ailment in cattle herds, resulting in substantial losses attributed to mortality, treatment expenses, and impaired calf growth. The aim of this study was to establish data about the occurrence of the main bacterial agents involved in diarrhea in dairy calves in the state of Maranhão, as well as to determine the most effective and/or resistant antibiotics, establishing a foundation for treatment and prevention protocols. The samples were collected with rectal swabs and initially cultivated on sheep blood agar (5%) and MacConkey agar and later on Salmonella-Shigella agar and eosin-methylene blue agar. Gram staining, biochemical tests, and antibiograms were performed on the obtained colonies. Ten municipalities were studied, with 230 calves evaluated from ten dairy farms. A total of 21 animals exhibited clinical signs of diarrhea, representing a frequency of 9.13%. The frequency of positive farms was 35%, and in 50% of municipalities. Bacteria isolated belonged to the Enterobacteriaceae family, with 71.4% Escherichia coli, 14.3% Enterobacter sp., 9.5% Proteus sp. and 4.8% Klebsiella sp. On the antibiogram, the bacteria that showed the highest resistance levels were those of the Proteus genus, followed by Enterobacter sp. and E. coli. The bacteria found are relevant for both animal and human health due to their zoonotic potential and serve as a public health alert since the isolates in this study showed in vitro resistance to several antibiotics, which predisposes them to the emergence of multidrug-resistant bacteria.