bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neural Semantic Surface Maps
Authors: Morreale Luca , Aigerman Noam , Kim Vladimir G. , Mitra Niloy J. 
Published: April 2024

AbstractWe present an automated technique for computing a map between two genus‐zero shapes, which matches semantically corresponding regions to one another. Lack of annotated data prohibits direct inference of 3D semantic priors; instead, current state‐of‐the‐art methods predominantly optimize geometric properties or require varying amounts of manual annotation. To overcome the lack of annotated training data, we distill semantic matches from pre‐trained vision models: our method renders the pair of untextured 3D shapes from multiple viewpoints; the resulting renders are then fed into an off‐the‐shelf image‐matching strategy that leverages a pre‐trained visual model to produce feature points. This yields semantic correspondences, which are projected back to the 3D shapes, producing a raw matching that is inaccurate and inconsistent across different viewpoints. These correspondences are refined and distilled into an inter‐surface map by a dedicated optimization scheme, which promotes bijectivity and continuity of the output map. We illustrate that our approach can generate semantic surface‐to‐surface maps, eliminating manual annotations or any 3D training data requirement. Furthermore, it proves effective in scenarios with high semantic complexity, where objects are non‐isometrically related, as well as in situations where they are nearly isometric.
Sentiment and attitudes toward offsetting and the biodiversity market in online media articles
Authors: Theis Sebastian 
Published: April 2024

AbstractBiodiversity offsetting, a conservation approach to offset loss of habitat and ecosystem services, has been widely accepted and implemented in different legislative frameworks around the globe. I assigned sentiment scores (from −3 [very negative] to +3 [very positive]) to online news articles to examine public sentiment toward offsetting. I identified 86 pertinent articles published from 2013 to 2023 by web scraping online media outlets through keywords. I examined article content based on topics commonly associated in scientific literature with offsetting, such as risks or financial aspects. Most articles were from Australia (44%), 16% were from the United Kingdom, and 5% were from Colombia and Madagascar. Three distinct groups covered finances (n = 47), species, and social impacts of offsetting (n = 23) and offsetting frameworks (n = 16). Articles covering monetary and finance aspects had a lower predicted sentiment score (−0.72, 95% CI −0.98 to −0.47) than articles that covered new, alternative offsetting forms (−0.15, 95% CI −0.46 to 0.17), such as mitigation banking and credits. In articles focused on charismatic species and loss of livelihood, offsetting risk and social issues were associated with low sentiment scores (<−0.85). Sentiment scores were high for articles on offsetting at a multicountry or global scale (0.47, 95% CI −0.06 to 0.99), and scores were the lowest in Australia (−1.03, 95% CI −1.36 to −0.70). Public sentiment based on media articles was generally negative toward offsetting, and many of the ecological and methodological issues and risks were reflected in the articles, but mitigation measures as a prerequisite to offsetting were mentioned in only 18% of all articles. With the seemingly high public interest in conservation and hence offsetting, it will be imperative to expand the current breadth of information about offsetting that is being communicated or made available to the public.
Clinical assessment of momelotinib drug–drug interactions via CYP3A metabolism and transporters
Authors: Ho Yu Liu , Gorycki Pete , Ferron‐Brady Geraldine , Martin Paul , Vlasakakis Georgios 
Published: April 2024

AbstractMomelotinib—approved for treatment of myelofibrosis in adults with anemia—and its major active metabolite, M21, were assessed as drug–drug interaction (DDI) victims with a strong cytochrome P450 (CYP) 3A4 inhibitor (multiple‐dose ritonavir), an organic anion transporting polypeptide (OATP) 1B1/1B3 inhibitor (single‐dose rifampin), and a strong CYP3A4 inducer (multiple‐dose rifampin). Momelotinib DDI perpetrator potential (multiple‐dose) was evaluated with CYP3A4 and breast cancer resistance protein (BCRP) substrates (midazolam and rosuvastatin, respectively). DDI was assessed from changes in maximum plasma concentration (Cmax), area under the concentration–time curve (AUC), time to reach Cmax, and half‐life. The increase in momelotinib (23% Cmax, 14% AUC) or M21 (30% Cmax, 24% AUC) exposure with ritonavir coadministration was not clinically relevant. A moderate increase in momelotinib (40% Cmax, 57% AUC) and minimal change in M21 was observed with single‐dose rifampin. A moderate decrease in momelotinib (29% Cmax, 46% AUC) and increase in M21 (31% Cmax, 15% AUC) were observed with multiple‐dose rifampin compared with single‐dose rifampin. Due to potentially counteracting effects of OATP1B1/1B3 inhibition and CYP3A4 induction, multiple‐dose rifampin did not significantly change momelotinib pharmacokinetics compared with momelotinib alone (Cmax no change, 15% AUC decrease). Momelotinib did not alter the pharmacokinetics of midazolam (8% Cmax, 16% AUC decreases) or 1′‐hydroxymidazolam (14% Cmax, 16% AUC decreases) but increased rosuvastatin Cmax by 220% and AUC by 170%. Safety findings were mild in this short‐term study in healthy volunteers. This analysis suggests that momelotinib interactions with OATP1B1/1B3 inhibitors and BCRP substrates may warrant monitoring for adverse reactions or dose adjustments.
Assembly of continuous high‐resolution draft genome sequence of Hemicentrotus pulcherrimus using long‐read sequencing
Authors: Komoto Tetsushi , Ikeo Kazuho , Yaguchi Shunsuke , Yamamoto Takashi , Sakamoto Naoaki , Awazu Akinori 
Published: April 2024

AbstractThe update of the draft genome assembly of sea urchin, Hemicentrotus pulcherrimus, which is widely studied in East Asia as a model organism of early development, was performed using Oxford nanopore long‐read sequencing. The updated assembly provided ~600‐Mb genome sequences divided into 2,163 contigs with N50 = 516 kb. BUSCO completeness score and transcriptome model mapping ratio (TMMR) of the present assembly were obtained as 96.5% and 77.8%, respectively. These results were more continuous with higher resolution than those by the previous version of H. pulcherrimus draft genome, HpulGenome_v1, where the number of scaffolds = 16,251 with a total of ~100 Mb, N50 = 143 kb, BUSCO completeness score = 86.1%, and TMMR = 55.4%. The obtained genome contained 36,055 gene models that were consistent with those in other echinoderms. Additionally, two tandem repeat sequences of early histone gene locus containing 47 copies and 34 copies of all histone genes, and 185 of the homologous sequences of the interspecifically conserved region of the Ars insulator, ArsInsC, were obtained. These results provide further advance for genome‐wide research of development, gene regulation, and intranuclear structural dynamics of multicellular organisms using H. pulcherrimus.
Real effect of anticorruption on acquisition premium: Evidence from China
Authors: Liu Xin , Pan Ailing 
Published: April 2024

AbstractAnticorruption is a prevalent global phenomenon and has yielded many good results. This study empirically tests the real effect of China's anticorruption on corporate acquisition premiums and explores its mechanisms. We find that after the exposure of and crackdown on corrupt provincial officials, firms without political connections had lower mergers and acquisitions (M&A) premiums than those with political connections. Cross‐sectional test results show that when firms are private or in areas with high marketization, the anticorruption event has a greater impact on their acquisition premiums. The channel test demonstrates that anticorruption reduces the value of political connections and improves the negotiation advantages of nonpolitically connected firms, enabling them to pay lower M&A premiums. Our findings indicate that anticorruption can create a considerably fair business environment. Moreover, we confirm the real effects of anticorruption on the distortion of resource allocation at the firm level. Finally, the results of this research have policy implications for the world's largest emerging market.
Predicting the potential distribution of Perina nuda under climate change in China
Authors: Mao Xinjie , Zheng Huisen , Liao Songkai , Wei Hongjian , Lin Haoyu , Wang Qi , Chen Hui 
Published: April 2024

AbstractPerina nuda (Fabricius) (Lepidoptera: Lymantriidae) is an important leaf‐feeding pest of Ficus species. It significantly affects the growth and reproduction of Ficus species, the economic prospects of growers, and the beauty of urban gardens. This study employed the MaxEnt model to predict and analyze the potential distribution of P. nuda in China, utilizing global distribution data and the correlation between the distribution of P. nuda and environmental variables. The results showed that the dominant environmental variables influencing the distribution of P. nuda included the warmest quarterly precipitation, coldest monthly minimum temperature, annual precipitation, and wettest monthly precipitation. The potential distribution area of P. nuda in China under current climatic conditions is 158 × 104 km2, accounting for 16.4% of the total area of the country. According to the SSP5‐8.5 scenario in 2050, the potential distribution area of P. nuda is projected to reach 200 × 104 km2, an increase of 26.5% compared to the current. P. nuda is widespread in China and has a tendency to spread, threatening the growth of Ficus species. This study is important for monitoring and control of P. nuda in areas where it is present, and where it may be present in the future.
Sickle Cell Health Awareness, Perspectives, and Experiences (SHAPE) survey: Perspectives of adolescent and adult patients, caregivers, and healthcare professionals on the burden of sickle cell disease
Authors: de Montalembert Mariane , Anderson Alan , Costa Fernando F. , Inusa Baba P. D. , Jastaniah Wasil , Kunz Joachim B. , Tinga Biba , Ingoli Elvie , James John , Hartfield Regina , Beaubrun Anne , Lartey Belinda , Odame Isaac 
Published: April 2024

AbstractObjectivesSickle cell disease (SCD) is an inherited disorder that causes lifelong complications, substantially impacting the physical and emotional well‐being of patients and their caregivers. Studies investigating the effects of SCD on quality of life (QOL) are often limited to individual countries, lack SCD‐specific QOL questionnaires, and exclude the caregiver experience. The SHAPE survey aimed to broaden the understanding of the global burden of SCD on patients and their caregivers and to capture the viewpoint of healthcare providers (HCPs).MethodsA total of 919 patients, 207 caregivers, and 219 HCPs from 10, 9, and 8 countries, respectively, answered a series of closed‐ended questions about their experiences with SCD.ResultsThe symptoms most frequently reported by patients were fatigue/tiredness (84%) and pain/vaso‐occlusive crises (71%). Patients' fatigue/tiredness had one of the greatest impacts on both patients' and caregivers' QOL. On average, patients and caregivers reported missing 7.5 days and 5.0 days per month, respectively, of school or work. HCPs reported a need for effective tools to treat fatigue/tiredness and a desire for more support to educate patients on long‐term SCD‐related health risks.ConclusionsThe multifaceted challenges identified using the SHAPE survey highlight the global need to improve both patient and caregiver QOL.
The impact of cultural stress on family functioning among Puerto Rican displaced families and the effect on mental health
Authors: García María Fernanda , Montero‐Zamora Pablo , Salas‐Wright Christopher P. , Maldonado‐Molina Mildred , Pineros‐Leano Maria , Hodges J. C. , Bates Melissa , Brown Eric C. , Rodríguez Jose , Calderón Ivonne , Schwartz Seth J. 
Published: April 2024

AbstractHurricane María caused significant devastation on the island of Puerto Rico, impacting thousands of lives. Puerto Rican crisis migrant families faced stress related to displacement and relocation (cultural stress), often exhibited mental health symptoms, and experienced distress at the family level. Although cultural stress has been examined as an individual experience, little work has focused on the experience as a family. To address this gap, we conducted a mixed‐methods study designed to examine the predictive effects of cultural stress on family conflict and its mental health implications among Puerto Rican Hurricane María parent and child dyads living on the U.S. mainland. In the quantitative phase of the study, 110 parent–child dyads completed an online survey assessing cultural stress, family dynamics, and mental health. As part of our primary analysis, we estimated a structural equation path model. Findings from the quantitative phase showed a significant positive relationship between family cultural stress and family conflict, as well as individual parent and child mental health symptoms. In the qualitative phase of the study, 35 parent–child dyads participated in individual interviews. Findings from the interviews revealed variations in difficulties related to language, discrimination, and financial burdens, with some participants adapting more quickly and experiencing fewer stressors. Findings also highlight the impact on mental health for both parents and youth, emphasizing the family‐level nature of cultural stress, while noting a potential discrepancy between qualitative and quantitative findings in the discussion of family conflict.
Inhibiting stress corrosion cracking of a prefabricated surface‐defective magnesium alloy thanks to biological organic components
Authors: Chen Lianxi , Li Xiaorong , Gu Haicheng , Zhang Xueying , Niu Ben , Zhang Zhiguo , Wang Xiaojian , Chen Dongchu , Zhao Chunwang 
Published: April 2024

AbstractBiomedical magnesium (Mg) alloys remain a challenge for their mainstream application, because the combination of bio‐mechanical stress and corrosive physiological environment leading to stress corrosion cracking (SCC). It is crucial to avoid the sudden brittle fracture of Mg alloys in vivo for predicting their service duration. However, the key factors, such as surface or physiological environment features, determining the origination or propagation of SCC behavior are still unclear. In the present study, a prefabricated surface defects coating was prepared by the phytic acid (PA, C6H18O24P6) conversion treatment. Four mimicking physiological media were used, ranging from simple to equivalent (Dulbecco's Modified Eagle Medium and Protein [DMEM+Pro]). The results showed that the PA film with numerous micro‐cracks provided limited protective ability in synthetic biological media. A striking finding was determined that although initial high corrosion rate of samples in DMEM+Pro led to an increased SCC nucleation, significant ductile fracture with elongation to failure (14.86%) was observed. Combined with the fracture features, the adsorption or deposition of biological composition into the tunnel of SCC cracks significantly inhibited the hydrogen embrittlement (HE) behavior. These results indicate that preventing the propagation of SCC crack by biological composition, rather than nucleation, plays a key role in avoiding the sudden fracture of Mg alloys. It provides a novel perspective to determine the non‐brittle fracture of Mg alloys for biomedical applications.
Carbon footprint of synthetic nitrogen under staple crops: A first cradle‐to‐grave analysis
Authors: Abdo Ahmed I. , Sun Daolin , Yang Kai , Li Yazheng , Shi Zhaoji , Abd Allah W. E. , El‐Sobky El‐Sayed E. A. , Wei Hui , Zhang Jiaen , Kuzyakov Yakov 
Published: April 2024

AbstractMore than half of the world's population is nourished by crops fertilized with synthetic nitrogen (N) fertilizers. However, N fertilization is a major source of anthropogenic emissions, augmenting the carbon footprint (CF). To date, no global quantification of the CF induced by N fertilization of the main grain crops has been performed, and quantifications at the national scale have neglected the CO2 assimilated by plants. A first cradle‐to‐grave life cycle assessment was performed to quantify the CF of the N fertilizers' production, transportation, and application to the field and the uses of the produced biomass in livestock feed and human food, as well as biofuel production. We quantified the direct and indirect inventories emitted or sequestered by N fertilization of main grain crops: wheat, maize, and rice. Grain food produced with N fertilization had a net CF of 7.4 Gt CO2eq. in 2019 after excluding the assimilated C in plant biomass, which accounted for a quarter of the total CF. The cradle (fertilizer production and transportation), gate (fertilizer application, and soil and plant systems), and grave (feed, food, biofuel, and losses) stages contributed to the CF by 2%, 11%, and 87%, respectively. Although Asia was the top grain producer, North America contributed 38% of the CF due to the greatest CF of the grave stage (2.5 Gt CO2eq.). The CF of grain crops will increase to 21.2 Gt CO2eq. in 2100, driven by the rise in N fertilization to meet the growing food demand without actions to stop the decline in N use efficiency. To meet the targets of climate change, we introduced an ambitious mitigation strategy, including the improvement of N agronomic efficiency (6% average target for the three crops) and manufacturing technology, reducing food losses, and global conversion to healthy diets, whereby the CF can be reduced to 5.6 Gt CO2eq. in 2100.
Rapid and sustained resolution in generalized pustular psoriasis with IL‐17A inhibitors required high adherence: a 96‐week analysis in a real‐life setting
Authors: Hu Kun , Liu Yijie , Liu Yizhang , Jian Lu , Duan Yongfang , Liu Ruizhen , Zhang Haoqun , Chen Junchen , Zhang Mi , Kuang Yehong 
Published: April 2024

AbstractBackgroundGeneralized pustular psoriasis (GPP) is a rare, potentially life‐threatening skin disease often requiring long‐term therapy. We aimed to evaluate the use of Interleukin (IL)‐17A inhibitors (secukinumab and ixekizumab) in GPP patients over 96 weeks.MethodsWe retrospectively analyzed a case series of 18 patients with GPP who received secukinumab (n = 13) and ixekizumab (n = 5) therapy with a 96‐week follow‐up period. The primary effectiveness analysis included determining the percentage of patients who achieved ≥90% or 100% improvement in the Generalized Pustular Psoriasis Area and Severity Index (GPPASI) score. Adherence was captured using the medication possession ratio (MPR).ResultsUsing the as‐observed (AO) method, 87% and 67% of patients treated with secukinumab or ixekizumab achieved GPPASI 90 and 100 responses, respectively. At Week 96, the mean GPPASI improvements from baseline GPPASI were 96.3% (95% CI: 0.91–1.01) using the AO method. After Week 48, 14 patients tapered (n = 8) or terminated (n = 6) the treatment. High‐adherence therapy (MPR ≥ 80%) was significantly superior to the low‐adherence group in the rate of patients achieving a GPPASI 100 response (AO, 100% vs. 38%, P < 0.05). By Week 96, 5 (27.8%) patients had new GPP flares, and 4 (80%) were in the low‐adherence group. No new safety signals occurred.ConclusionIL‐17A inhibitors led to effective and sustained improvement in GPP patients, and high‐adherence therapy had long‐term positive effects on skin clearance. Given its relapsing nature, improving compliance is beneficial for long‐term clinical management.
Does skill emigration hurt unskilled workers? Theory and cross‐country evidence
Authors: Kar Saibal , Marjit Sugata 
Published: April 2024

AbstractHow does out‐migration of skilled workers affect unskilled workers' wage in the source country? When skilled workers emigrate, unskilled wages tend to go down in some countries. If the sector that uses both skilled and unskilled workers shows a lower degree of capital intensity as compared to sectors that use only skilled workers in production, it is a common outcome. We use 19 years of cross‐country data from the International Labor Organization (ILO) spanning Asia and Latin America to show that skill emigration reduces unskilled wage unambiguously for panel fixed effects and difference generalized method of moments (DGMM) estimates. The structure is also subjected to system GMM with endogenous covariates and allied robustness checks. Importantly, we find a critical level of tertiary education, such that countries generating more skill shall face weaker negative impact on unskilled wages.
Medical database analysis of the association between kidney function and achievement of glycemic control in older Japanese adults with type 2 diabetes who started with oral antidiabetic drugs
Authors: Suzuki Ryo , Kazumori Kiyoyasu , Usui Tatsuya , Shinohara Masahiko 
Published: April 2024

AbstractAims/IntroductionDespite the emergence of new drugs with novel mechanisms of action, treatment options for older people and those with chronic kidney disease are still limited.Materials and MethodsUsing a medical database compiled from Diagnostic Procedure Combination hospitals, we retrospectively analyzed treatment status, glycemic control and kidney function over 3 years after the first oral antidiabetic drugs in Japanese adults with type 2 diabetes who were aged ≥65 years.ResultsAmong 5,434 study participants, 3,246 (59.7%) were men, the median age was 72.0 years, the baseline median hemoglobin A1c was 7.1% and the baseline median estimated glomerular filtration rate was 66.6 mL/min/1.73 m2. Treatment was intensified in 40.0% of people during the 3‐year observation period, and the median time to the first treatment intensification was 198 days. Insulin was the most commonly used agent for treatment intensification (36.9%, 802/2,175). Hemoglobin A1c of <7.0% was achieved in 3,571 (65.7%) at 360 ± 90 days. Multivariable logistic regression analysis found that baseline age, hemoglobin A1c and estimated glomerular filtration rate were negatively associated with achieving hemoglobin A1c of <7.0% at 360 ± 90 days.ConclusionsIn older Japanese adults with type 2 diabetes, those with a lower estimated glomerular filtration rate were more likely to achieve hemoglobin A1c of <7.0%. To safely manage blood glucose levels in older adults with chronic kidney disease, physicians should remain vigilant about the risk of iatrogenic hypoglycemia.
Plantar pressure measurement in diabetic foot disease: A scoping review
Authors: Lockhart Michael , Dinneen Sean F , O'Keeffe Derek T 
Published: April 2024

ABSTRACTAims/IntroductionPatients with a healed diabetic foot ulcer (DFU) have a 40% risk of ulcer recurrence within a year. New and effective measures to prevent DFU recurrence are essential. We aimed to highlight emerging trends and future research opportunities in the use of plantar pressure measurement to prevent DFU recurrence.Materials and MethodsOur scoping review protocol was drafted using the Preferred Reporting Items for Systematic Reviews and Meta‐analysis – Scoping Review protocol. Peer‐reviewed, English‐language papers were included that addressed both plantar pressure measurement and diabetic foot disease, either as primary studies that have advanced the field or as review papers that provide summaries and/or opinion on the field as a whole, as well as specific papers that provide guidelines for future research and advancement in the field.ResultsA total of 24 eligible publications were identified in a literature search using PubMed. A further 36 eligible studies were included after searching the references sections of these publications, leaving a total of 60 publications included in this scoping review.ConclusionsPlantar pressure measurement can and will play a major role in the prevention of DFU. There is already a strong, albeit limited, evidence base in place to prove its benefit in reducing DFU recurrence. More research is required in larger populations, using remote monitoring in real‐world settings, and with improved technology.