bluuebunny/crossref_metadata_2025_split huggingface dataset:
Functional central limit theorems for rough volatility
Authors: Horvath Blanka , Jacquier Antoine , Muguruza Aitor , Søjmark Andreas 
Published: April 2024

AbstractThe non-Markovian nature of rough volatility makes Monte Carlo methods challenging, and it is in fact a major challenge to develop fast and accurate simulation algorithms. We provide an efficient one for stochastic Volterra processes, based on an extension of Donsker’s approximation of Brownian motion to the fractional Brownian case with arbitrary Hurst exponent $H \in (0,1)$
H
∈
(
0
,
1
)
. Some of the most relevant consequences of this ‘rough Donsker (rDonsker) theorem’ are functional weak convergence results in Skorokhod space for discrete approximations of a large class of rough stochastic volatility models. This justifies the validity of simple and easy-to-implement Monte Carlo methods, for which we provide detailed numerical recipes. We test these against the current benchmark hybrid scheme and find remarkable agreement (for a large range of values of $H$
H
). Our rDonsker theorem further provides a weak convergence proof for the hybrid scheme itself and allows constructing binomial trees for rough volatility models, the first available scheme (in the rough volatility context) for early exercise options such as American or Bermudan options.
Prevalence of lingual sensory impairment following bilateral sagittal split osteotomy: a systematic review and meta-analysis
Authors: Kostares Evangelos , Kostares Michael , Kostare Georgia , Kantzanou Maria 
Published: April 2024

Abstract
Purpose
Our study aims to estimate the prevalence of lingual nerve injury following bilateral sagittal split osteotomy (BSSO).

Methods
Two reviewers independently conducted a systematic literature search in the Medline and Scopus databases. The pooled prevalence with 95% confidence intervals (CI) was estimated, and quality assessment, outlier analysis, and influential analysis were performed.

Results
In total, eleven eligible studies comprising a total of 1,882 participants were included in this meta-analysis. One study was identified as critically influential. The overall prevalence of lingual sensory impairment was estimated to be as high as 0.1% (95% CI 0.0%-0.6%) with moderate heterogeneity observed between studies.

Conclusion
It is important for healthcare professionals to be aware of this issue, despite the relatively low rate of lingual nerve deficit after BSSO. Additional research will provide a more comprehensive understanding of the underlying factors contributing to lingual nerve injury, leading to improved preventive measures and treatment strategies. Furthermore, insights gained from future studies will enable healthcare professionals to inform patients about the potential complications and manage their expectations before undergoing BSSO.
End-colostomy parastomal hernia repair: a systematic review on laparoscopic and robotic approaches
Authors: Sarno G. , Iacone B. , Tedesco A. , Gargiulo A. , Ranieri A. , Giordano A. , Tramontano S. , Bracale U. 
Published: April 2024

Abstract
Introduction
Parastomal hernia (PSH) is the most common and challenging complication after stoma creation, with an estimated 50% incidence 2 years after the index surgery. Mesh repair is the treatment of choice. Laparoscopic and/or robotic approaches allow acceptable outcomes.

Materials and methods
A systematic literature review from January 2012 to November 2023 was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Embase, PubMed, and Scopus search were performed to select articles dealing with minimally invasive surgical treatment for PSH after end colostomy.

Results
603 studies were found, and 24 were chosen. When compared to open surgery, laparoscopy showed decreased postoperative complications and recurrence. The main laparoscopic approaches are the keyhole (KH), the Sugarbaker (SB), and the sandwich technique. Continuous improvement in surgery, mesh technology, and surgeons’ expertise led to an amelioration of surgical outcome and recurrence rate after repair. Recent studies showed comparable outcomes for SB and KH techniques, while novel surgical approaches have been proposed in an attempt to further increase the operative and long-term results. Reports on PSH robotic repairs are scarce and describe small series results, suggesting a role of the initial learning curve as a risk factor for complications.

Conclusion
End-colostomy PSH surgical repair still represents a challenge for surgeons. Recent evidence has not shown a significant advantage in postoperative complications and recurrence with a specific repair among SB, KH, and sandwich technique. The paucity of data on robotic surgery does not allow to draw definitive conclusion. Further primary, multicentric, and larger cohort studies are needed.
Perception of vocoded speech in domestic dogs
Authors: Mallikarjun Amritha , Shroads Emily , Newman Rochelle S. 
Published: April 2024

Abstract
Humans have an impressive ability to comprehend signal-degraded speech; however, the extent to which comprehension of degraded speech relies on human-specific features of speech perception vs. more general cognitive processes is unknown. Since dogs live alongside humans and regularly hear speech, they can be used as a model to differentiate between these possibilities. One often-studied type of degraded speech is noise-vocoded speech (sometimes thought of as cochlear-implant-simulation speech). Noise-vocoded speech is made by dividing the speech signal into frequency bands (channels), identifying the amplitude envelope of each individual band, and then using these envelopes to modulate bands of noise centered over the same frequency regions – the result is a signal with preserved temporal cues, but vastly reduced frequency information. Here, we tested dogs’ recognition of familiar words produced in 16-channel vocoded speech. In the first study, dogs heard their names and unfamiliar dogs’ names (foils) in vocoded speech as well as natural speech. In the second study, dogs heard 16-channel vocoded speech only. Dogs listened longer to their vocoded name than vocoded foils in both experiments, showing that they can comprehend a 16-channel vocoded version of their name without prior exposure to vocoded speech, and without immediate exposure to the natural-speech version of their name. Dogs’ name recognition in the second study was mediated by the number of phonemes in the dogs’ name, suggesting that phonological context plays a role in degraded speech comprehension.
Long-term treatment of hereditary transthyretin amyloidosis with patisiran: multicentre, real-world experience in Italy
Authors: Gentile Luca , Mazzeo Anna , Briani Chiara , Casagrande Silvia , De Luca Marcella , Fabrizi Gian Maria , Gagliardi Christian , Gemelli Chiara , Forcina Francesca , Grandis Marina , Guglielmino Valeria , Iabichella Giacomo , Leonardi Luca , Lozza Alessandro , Manganelli Fiore , Mussinelli Roberta , My Filomena , Occhipinti Giuseppe , Fenu Silvia , Russo Massimo , Romano Angela , Salvalaggio Alessandro , Tagliapietra Matteo , Tozza Stefano , Palladini Giovanni , Obici Laura , Luigetti Marco 
Published: April 2024

Abstract
Background
Hereditary transthyretin (ATTRv, v for variant) amyloidosis with polyneuropathy is a rare disease caused by mutations in the transthyretin gene. In ATTRv amyloidosis, multisystem extracellular deposits of amyloid cause tissue and organ dysfunction. Patisiran is a small interfering RNA molecule drug that reduces circulating levels of mutant and wild-type TTR proteins. Prior to its regulatory approval, patisiran was available in Italy through a compassionate use programme (CUP). The aim of this study was to analyse the long-term outcomes of patients who entered into the CUP.

Methods
This was a multicentre, observational, retrospective study of patients with ATTRv amyloidosis treated with patisiran. The analysis included change from baseline to 12, 24, 36 and 48 months in familial amyloid polyneuropathy (FAP) stage, polyneuropathy disability (PND) class, neuropathy impairment score (NIS), modified body mass index (mBMI), Compound Autonomic Dysfunction Test (CADT), Karnofsky Performance Status (KPS) scale and Norfolk Quality of Life–Diabetic Neuropathy (QoL-DN) questionnaire. Safety data were also analysed.

Results
Forty patients from 11 Italian centres were enrolled: 23 in FAP 1 (6 in PND 1 and 17 in PND 2) and 17 in FAP 2 (8 in PND 3a and 9 in PND 3b) stage. In this population, the mean NIS at baseline was 71.4 (± 27.8); mBMI, 917.1 (± 207) kg/m2; KPS, 67.1 (± 14.0); Norfolk QoL-DN, 62.2 (± 25.2); and CADT, 13.2 (± 3.3). Statistical analysis showed few significant differences from baseline denoting disease stability. No new safety signals emerged.

Conclusions
Patisiran largely stabilised disease in patients with ATTRv amyloidosis.
Investigation of total cerebellar and flocculonodular lobe volume in Parkinson’s disease and healthy individuals: a brain segmentation study
Authors: Ozgen Merve Nur , Sahin Necati Emre , Ertan Nurcan , Sahin Bunyamin 
Published: April 2024

Abstract
Background
Parkinson’s disease (PD) is a neurodegenerative disorder with an unexplored link to the cerebellum. In the pathophysiology of balance disorders in PD, the role of the flocculonodular lobe (FL) is linked to the impairment of the dopaminergic system. Dopamine deficiency can also lead to changes in cerebellum functions, disrupting balance control. This study compares cerebellar and FL volumes between healthy controls (HC) and PD patients, analyzing their correlation with clinical outcomes.

Methods
We used magnetic resonance images of 23 PD patients (14 male, 9 female) and 24 HC (9 male, 15 female). Intracranial (ICV), total cerebellar, FL, and cerebellar gray matter volumes were measured using VolBrain. Clinical outcomes in PD patients were assessed using the Unified Parkinson’s Disease Rating Scale (UPDRS-III) to evaluate motor function, with scores correlated to volumetric data.

Results
The cerebellar and gray matter volumes in HC were 115.53 ± 10.44 cm3 and 84.83 ± 7.76 cm3, respectively, compared to 126.83 ± 13.47 cm3 and 92.37 ± 9.45 cm3 in PD patients, indicating significantly larger volumes in PD patients (p < 0.05). The flocculonodular lobe gray matter volume was 1.14 ± 0.19 cm3 in PD patients and 1.02 ± 0.13 cm3 in HC, but there was a significant increase in gray matter volume in PD patients between the groups (p < 0.05). In PD patients, significant negative correlations were observed between FL volume and the UPDRS-III scores (r =  − 0.467, p = 0.033) and between UPDRS-III scores and both total (r =  − 0.453, p = 0.039) and normalized (r =  − 0.468, p = 0.032) gray matter volumes of the FL.

Conclusion
Although total gray matter volumes were larger in PD patients, the volumes of FL did not differ between groups. In Parkinson’s disease, increased cerebellar volume may regulate fine motor movements rather than balance.
Local anesthesia with sedation and general anesthesia for the treatment of chronic subdural hematoma: a systematic review and meta-analysis
Authors: Abdelhady Mariam Ahmed , Aljabali Ahmed , Al-Jafari Mohammad , Serag Ibrahim , Elrosasy Amr , Atia Ahmed , Ehab Aya , Mohammed Shrouk F. , Alkhawaldeh Ibraheem M. , Abouzid Mohamed 
Published: April 2024

Abstract
Background
Surgery is the primary treatment for chronic subdural hematoma, and anesthesia significantly impacts the surgery's outcomes. A previous systematic review compared general anesthesia to local anesthesia in 319 patients. Our study builds upon this research, analyzing 4,367 cases to provide updated and rigorous evidence.

Methods
We systematically searched five electronic databases: PubMed, Cochrane Library, Scopus, Ovid Medline, and Web of Science, to identify eligible comparative studies. All studies published until September 2023 were included in our analysis. We compared six primary outcomes between the two groups using Review Manager Software.

Results
Eighteen studies involving a total of 4,367 participants were included in the meta-analysis. The analysis revealed no significant difference between the two techniques in terms of 'recurrence rate' (OR = 0.95, 95% CI [0.78 to 1.15], P = 0.59), 'mortality rate' (OR = 1.02, 95% CI [0.55 to 1.88], P = 0.96), and 'reoperation rate' (OR = 0.95, 95% CI [0.5 to 1.79], P = 0.87). Local anesthesia demonstrated superiority with a lower 'complications rate' than general anesthesia, as the latter had almost 2.4 times higher odds of experiencing complications (OR = 2.4, 95% CI [1.81 to 3.17], P < 0.00001). Additionally, local anesthesia was associated with a shorter 'length of hospital stay' (SMD = 1.19, 95% CI [1.06 to 1.32], P < 0.00001) and a reduced 'duration of surgery' (SMD = 0.94, 95% CI [0.67 to 1.2], P < 0.00001).

Conclusion
Surgery for chronic subdural hematoma under local anesthesia results in fewer complications, a shorter length of hospital stay, and a shorter duration of the operation.
Early experience and future prospects regarding use of newly developed surgical robot system, hinotori, in the field of urologic cancer surgery
Authors: Miyake Hideaki , Fujisawa Masato 
Published: April 2024

AbstractIn the field of urology, robotic surgery has gained rapid and wide acceptance as a standard surgical approach in the majority of major surgeries over the last decade. To date, the da Vinci surgical system has been the dominant platform in robotic surgery; however, several newly developed robotic systems have recently been introduced in routine clinical practice. Of these, hinotori, the first made-in-Japan robotic system, is characterized by various unique and attractive features different from the existing system, and the use of this system has gradually increased mainly in urologic cancer surgeries, including radical prostatectomy, partial nephrectomy, radical nephrectomy, and radical nephroureterectomy. This review initially describes detailed characteristics of hinotori, then summarizes the early experience with urologic cancer surgeries using hinotori at our institution, and finally discusses the future prospects of robotic surgery using hinotori, considering problems associated with the use of this robotic system.
Same landscape, different connectivity: contrasting patterns of gene flow in two sympatric ungulates in a mountain area
Authors: Lecis Roberta , Chirichella Roberta , Dondina Olivia , Orioli Valerio , Azzu Silvia , Canu Antonio , Torretta Elisa , Bani Luciano , Apollonio Marco , Scandura Massimo 
Published: April 2024

AbstractComparative landscape genetics studies provide insights on the impact of landscape elements on gene flow patterns of different species inhabiting the same geographic area. We investigated the population genetic structure of two sympatric ungulates, roe deer Capreolus capreolus and Northern chamois Rupicapra rupicapra, in a mountain area of the central Italian Alps (Trentino, northern Italy). A total of 122 chamois and 72 roe deer samples were genotyped by two species-specific panels of 11 polymorphic microsatellite loci and analyzed by aspatial and spatially explicit analyses. While the roe deer population resulted unstructured, a clear population structure was detected in chamois, with two main groups, one inhabiting the eastern and the other spread in the western part of the study area. Landscape genetics analysis confirmed these scenarios and revealed a different effect of landscape on gene flow. An IBD (Isolation-By-Distance) model best explained genetic variation in roe deer, while IBR (Isolation-By-Resistance) was found as the process underlying genetic variation patterns in chamois, suggesting arable lands, coniferous forests, watercourses, and main roads as potential barriers. Species distribution and landscape use might explain these results: roe deer mostly occupy valley floors relatively connected to each other, and their spatial behavior may promote gene flow across areas. On the other hand, chamois prefer higher elevations and their movements may be hindered by valleys, rivers, and road networks. This study highlights the different impacts of natural and anthropic landscape elements on gene flow in two sympatric species, resulting from their different ecological requirements.
Bioprospecting of extremophilic perchlorate-reducing bacteria: report of promising Bacillus spp. isolated from sediments of the bay of Cartagena, Colombia
Authors: Acevedo-Barrios Rosa , Tirado-Ballestas Irina , Bertel-Sevilla Angela , Cervantes-Ceballos Leonor , Gallego Jorge L. , Leal María Angélica , Tovar David , Olivero-Verbel Jesús 
Published: April 2024

AbstractThree extremophile bacterial strains (BBCOL-009, BBCOL-014 and BBCOL-015), capable of degrading high concentrations of perchlorate at a range of pH (6.5 to 10.0), were isolated from Colombian Caribbean Coast sediments. Morphological features included Gram negative strain bacilli with sizes averaged of 1.75 × 0.95, 2.32 × 0.65 and 3.08 × 0.70 μm, respectively. The reported strains tolerate a wide range of pH (6.5 to 10.0); concentrations of NaCl (3.5 to 7.5% w/v) and KClO4− (250 to 10000 mg/L), reduction of KClO4− from 10 to 25%. LB broth with NaCl (3.5–30% w/v) and KClO4ˉ (250-10000 mg/L) were used in independent trials to evaluate susceptibility to salinity and perchlorate, respectively. Isolates increased their biomass at 7.5 % (w/v) NaCl with optimal development at 3.5 % NaCl. Subsequently, ClO4ˉ reduction was assessed using LB medium with 3.5% NaCl and 10000 mg/L ClO4ˉ. BBCOL-009, BBCOL-014 and BBCOL-015 achieved 10%, 17%, and 25% reduction of ClO4ˉ, respectively. The 16 S rRNA gene sequence grouped them as Bacillus flexus T6186-2, Bacillus marisflavi TF-11 (T), and Bacillus vietnamensis 15 − 1 (T) respectively, with < 97.5% homology. In addition, antimicrobial resistance to ertapenem, vancomycine, amoxicillin clavulanate, penicillin, and erythromycin was present in all the isolates, indicating their high adaptability to stressful environments. The isolated strains from marine sediments in Cartagena Bay, Colombia are suitable candidates to reduce perchlorate contamination in different environments. Although the primary focus of the study of perchlorate-reducing and resistant bacteria is in the ecological and agricultural realms, from an astrobiological perspective, perchlorate-resistant bacteria serve as models for astrobiological investigations.
Participation Strategies and Ethical Considerations in NGO Led Community-Based Conservation Initiatives
Authors: Ghafran Chaudhry , Yasmin Sofia 
Published: April 2024

Abstract
This study examines the participation strategies of an environmental non-governmental organization (NGO) in community-based conservation (CBC) initiatives in the developing country context of Pakistan. We use local Pakistani concepts and terms to interpret and narrate our study. Drawing on the micro-mobilization literature, our analysis embeds a situated analysis of the ‘biradari’ (kinship) structures that pervade Pakistani social and cultural milieu. We shed light on the importance of various gatekeepers in providing access and ongoing support for CBC initiatives, suggesting NGOs must navigate complex cultural and social structures to manage participation in developing country contexts. Here our findings point to the importance of local knowledge not just in articulating community needs but also in articulating participation strategies. Furthermore, even though ‘elite’ structures have the potential to jeopardize equitable participation and project long-term sustainability, our analysis suggests interacting and gaining ‘bharosa’ (trust) of communities’ via these structures is critical to participation. While previous research has called into doubt the efficacy of CBC in advancing conservation, we suggest that frequent and culturally atoned engagement is a must for environmental NGOs working in socially entrenched developing nations. Our research brings to light the complex ethical terrain navigated by environmental NGOs in CBC projects, illuminating the inherent potential for both empowering and subjugating outcomes.
Self-Reported Concerns among Australian Secondary School Students: Associations with Mental Health and Wellbeing
Authors: Bartholomew Alexandra , Maston Kate , Brown Lyndsay , Fujimoto Hiroko , Hodgins Michael , Christensen Helen , Werner-Seidler Aliza 
Published: April 2024

Abstract
Background
Excessive worry during adolescence can significantly impact mental health. Understanding adolescent concerns may help inform mental health early intervention strategies.

Objective
This study aimed to identify frequent concerns among Australian secondary school students, exploring individual and demographic differences. Whether adolescents’ most frequently reported concern was associated with mental health and wellbeing was also investigated.

Methods
A total of N = 4086 adolescents (Mage = 13.92) participated in an online survey, reporting their top concerns alongside demographic characteristics, mental health, and wellbeing. Data were analysed using both qualitative and quantitative approaches.

Results
Thematic analysis identified 11 different themes of adolescent concerns. A frequency analysis showed concerns relating to ‘School and Academics’ were most common (24.52% of all responses), consistent across females, males, school location (regional vs metropolitan areas), and socioeconomic background. Sexuality and gender diverse adolescents more frequently reported concerns about ‘Mental Health and Wellbeing’ and ‘Social Relationships’. Linear mixed models found ‘School and Academic’ concerns were associated with lower symptoms of depression (p < .001, d = 0.16) and anxiety (p < .001, d = 0.19) and higher wellbeing (p = .03, d = 0.07) compared to all other concerns.

Conclusion
‘School and Academic’ concerns were most common, however not associated with poorer mental health or wellbeing. Sexuality and gender diverse adolescents were more likely to report concerns regarding ‘Mental Health and Wellbeing’ and ‘Social Relationships’. Efforts aimed solely at reducing academic stress may not be the most effective approach to improving adolescent mental health. Longitudinal data into how concerns evolve over time could provide a nuanced understanding of their relationship with future mental health challenges.
TIMP-3 Alleviates White Matter Injury After Subarachnoid Hemorrhage in Mice by Promoting Oligodendrocyte Precursor Cell Maturation
Authors: Guo Peiwen , Ru Xufang , Zhou Jiru , Chen Mao , Li Yanling , Duan Mingxu , Li Yuanshu , Li Wenyan , Chen Yujie , Zuo Shilun , Feng Hua 
Published: April 2024

AbstractSubarachnoid hemorrhage (SAH) is associated with high mortality and disability rates, and secondary white matter injury is an important cause of poor prognosis. However, whether brain capillary pericytes can directly affect the differentiation and maturation of oligodendrocyte precursor cells (OPCs) and subsequently affect white matter injury repair has still been revealed. This study was designed to investigate the effect of tissue inhibitor of metalloproteinase-3 (TIMP-3) for OPC differentiation and maturation. PDGFRβret/ret and wild-type C57B6J male mice were used to construct a mouse model of SAH via endovascular perforation in this study. Mice were also treated with vehicle, TIMP-3 RNAi or TIMP-3 RNAi + TIMP-3 after SAH. The effect of TIMP-3 on the differentiation and maturation of OPCs was determined using behavioral score, ELISA, transmission electron microscopy, immunofluorescence staining and cell culture. We found that TIMP-3 was secreted mainly by pericytes and that SAH and TIMP-3 RNAi caused a significant decrease in the TIMP-3 content, reaching a nadir at 24 h, followed by gradual recovery. In vitro, the myelin basic protein content of oligodendrocytes after oxyhemoglobin treatment was increased by TIMP-3 overexpression. The data indicates TIMP-3 could promote the differentiation and maturation of OPCs and subsequently improve neurological outcomes after SAH. Therefore, TIMP-3 could be beneficial for repair after white matter injury and could be a potential therapeutic target in SAH.
Graphical Abstract