bluuebunny/crossref_metadata_2025_split huggingface dataset:
Undiagnosed chronic monarthritis. clinical and evolutionary profile
Authors: Blocka Kenneth L. N. , Sibley John T. 
Published: February 2007

AbstractThe features and clinical course in 38 patients (25 women, 13 men) who had chronic monarthritis of undetermined origin (UCM) were surveyed over a mean followup period of 24.6 months. At the end of the study, the cause was still unknown in 26 patients (65.7%). In 10 patients, symptoms resolved spontaneously. In the remaining 12 patients, a diagnosis became apparent after a mean period of 17.2 months; diagnoses included spondylarthritis (6 patients), rheumatoid arthritis (3 patients), osteoarthritis (1 patient), erosive arthropathy (1 patient), and glomus tumor (1 patient). Patients in whom a diagnosis emerged were more likely to have positive findings on the following studies: rheumatoid factor (2 of 12); HLA—B27 typing (6 of 11); bone scan, positive over the sacroiliac joint or non‐index joint(s) (4 of 6); and roentgenograms of the sacroiliac joint (3 of 8). Findings of these same studies were notably negative in the subgroup of patients with UCM that spontaneously resolved.
One‐year experience in patients treated with auranofin following completion of a parallel, controlled trial comparing auranofin, gold sodium thiomalate, and placebo
Authors: James Williams H. , Dahl Stephen L. , Ward John R. , Karg Miki , Willkens Robert F. , Meenan Robert F. , Altz‐Smith Mary , Clegg Daniel O. , Mikkelsen William M. , Kay Donald R. , Weinstein Arthur , Guttadauria Maria , Paulus Harold E. , Kaplan Stanley B. 
Published: February 2007

AbstractFollowing a 21‐week double‐blind trial that compared the effects of treatment with auranofin (AUR), gold sodium thiomalate, and placebo in 193 patients, 147 patients entered a 1‐year, open‐label study of treatment with AUR (6 mg/day). Results of this open‐label study suggest that AUR has a long‐term use profile similar to that of other slow‐acting antirheumatic drugs. AUR appears to be capable of sustaining an initial response to gold sodium thiomalate. The withdrawal rate remains relatively high: Nearly half of the study patients had discontinued AUR by the end of 1 year.
Natural course of joint destruction and fluctuation of serum c1q levels in patients with rheumatoid arthritis
Authors: Ochi Takahiro , Iwase Rokuro , Yonemasu Kunio , Matsukawa Mitsuhiro , Yoneda Minoru , Yukioka Masao , Ono Keiro 
Published: February 2007

AbstractUsing the number of joints with erosion in a total of 68 joints throughout the body, we studied a population of patients with rheumatoid arthritis whose disease duration was 10–15 years. Three groups, each showing a Poisson distribution, were found: the subset with least erosive disease (LES), the subset with more erosive disease (MES), and the subset with mutilating disease (MUD). The mean number of joints with erosion was 10.9 in LES, 32.2 in MES, and 53.5 in MUD. In LES, erosive articular changes were primarily limited to the peripheral smaller joints. In MES, the larger axial joints were also involved. Almost all joints were extensively damaged in MUD. During the early period of disease, differences between the 3 groups were highly significant in the rapidity of carpal bone destruction, as assessed by the yearly reduction of carpal height ratio (P < 0.001), and in the serum C1q level (P < 0.001).
Incidence of anti‐human ig with restricted specificity in japanese, kuwaiti, and swedish patients with rheumatoid arthritis
Authors: Grubb R. , Matsumoto H. , Sattar M. A. 
Published: February 2007

AbstractAssuming that anti‐allotypic anti‐Ig in rheumatoid arthritis is stimulated by the individual's allotype, it would be reasonable to expect a higher incidence of anti‐G1m(a) in individuals carrying G1m(a). There is marked divergence among various populations in allotype frequencies. G1m(a) allotype and the prevalence of anti‐Ig reactive with G1m(a) Ig were determined in 18 Kuwaiti, 23 Japanese, and 41 Swedish rheumatoid arthritis patients. An inverse relationship was observed between the frequency distribution of allotype G1m(a) and anti‐allotype; thus, the stimulus for the anti‐allotype is not the patient's own allotype.
Characterization of the antigen reactive with anti‐scl‐70 antibodies and its application in an enzyme‐linked immunosorbent assay
Authors: Juarez C. , Vila J. L. , Gelpi C. , Agusti M. , Amengual M. J. , Martinez M. A. , Rodriguez J. L. 
Published: February 2007

AbstractThe characteristics of the Scl‐70 antigen (topoisomerase I) have been analyzed by means of autoantibodies. This antigen is a DNA‐binding protein, dissociable from DNA at 0.3M NaCl and bound to a fraction of DNA that is very sensitive to nucleases. The molecular weight of the antigen is 105,000 daltons, whether dissociation conditions are used or not. Using chicken erythrocytes, and taking advantage of the strong interaction of the antigen with hydroxyapatite, we have designed a simple and fast purification protocol that allows the determination of anti–topoisomerase I antibodies by enzyme‐linked immunosorbent assay.
Interleukin‐1 activates phospholipase a2 IN HUMAN SYNOVIAL CELLS
Authors: Gilman Steven C. , Chang Joseph , Zeigler Pamela R. , Uhl Joanne , Mochan Eugene 
Published: February 2007

AbstractInterleukin‐1 (IL‐1) treatment of synovial cells from rheumatoid arthritis and osteoarthritis patients resulted in a dose‐dependent secretion of phospholipase A2 (PLA2). IL‐1 also stimulated prostaglandin E2 and plasminogen activator synthesis, in parallel with PLA2 activation; all 3 were detectable within 6 hours of IL‐1 treatment and peaked by 24 hours. Synovial cell PLA2 required calcium (5 mM) and a neutral pH (7.5) for maximal activity and appears similar to the PLA2 in synovial fluid, which has been described previously. We conclude that PLA2 can be induced by IL‐1, and its secretion may contribute significantly to the inflammatory actions of IL‐1.
Clinical correlations and prognosis based on serum autoantibodies in patients with systemic sclerosis
Authors: Steen Virginia D. , Powell Donald L. , Medsger Thomas A. 
Published: February 2007

AbstractOf 397 systemic sclerosis (scleroderma) patients from the University of Pittsburgh, who had serum determinations of both anti–Scl‐70 and anticentromere antibody (ACA), 26% had anti‐Scl‐70 and 22% had ACA. No patient had both autoantibodies. Weak associations with HLA–DR5 and HLA‐DR1 were detected with anti‐Scl‐70 and ACA, respectively. ACA was found almost exclusively (96%) in patients with limited cutaneous scleroderma (the CREST syndrome variant), but the majority (57%) of patients with limited scleroderma did not have this antibody. Among patients with limited scleroderma, those with ACA more often had calcinosis and telangiectasias and less often had pulmonary interstitial fibrosis and restrictive lung disease. However, the frequency of pulmonary hypertension and the survival rates were similar in the ACA + and ACA‐ limited scleroderma patients. Two‐thirds of patients with anti‐Scl‐70 had diffuse scleroderma, but only 33% of all diffuse scleroderma patients had this antibody. Within the subset of diffuse scleroderma, anti‐Scl‐70 was associated with peripheral vascular disease (digital pitting scars) and pulmonary interstitial fibrosis, but was not predictive of cardiac or renal involvement or survival. ACA and anti–Scl‐70 are useful in diagnosing and classifying systemic sclerosis variants and in predicting the natural course of the disease. Their mutually exclusive occurrence suggests either 2 separate clinical entities or important host factors determining their production.
Evidence that a humoral immune response to autologous cartilage proteoglycan can participate in the induction of cartilage pathology
Authors: Kresina Thomas F. , Yoo Jung U. , Goldberg Victor M. 
Published: February 2007

AbstractWe examined antiproteoglycan antibodies as an autoimmune response for induction of synovitis. This hypothesis was studied by monitoring humoral antiproteoglycan antibody following IgG induction of experimental immune synovitis, localization in the articular cartilage of an autologous immune response, and loss of proteoglycan from cartilage following intravenous administration of antiproteoglycan monoclonal antibodies. The data support the hypothesis that autoimmunity to cartilage macromolecules may play a role in the etiopathogenesis of arthritis.
Arthritis in patients with psoriasis is associated with an immunoglobulin gene polymorphism
Authors: Sakkas L. I. , Demaine A. G. , Panayi G. S. , Welsh K. I. 
Published: February 2007

AbstractUsing a DNA probe for the switch region of immunoglobulin heavy chain genes, together with the restriction endonuclease Sst I, we detected a particular polymorphic DNA pattern in 17 of 28 patients (60.7%) with psoriatic arthropathy but in only 5 of 41 patients (12.2%) with psoriasis alone. Our findings suggest that genes in the immunoglobulin region confer susceptibility to the development of arthropathy in patients with psoriasis.
Clostridial septic arthritis: case report and review of the literature
Authors: Fauser Douglas J. , Zuckerman Joseph D. 
Published: February 2007

AbstractWe describe a patient who had septic arthritis caused by Clostridium perfringens. Clostridial organisms are very uncommon causes of septic arthritis. Only 13 cases have been reported previously. The diagnosis should be suspected in patients with a history of penetrating joint trauma and in immunocompromised patients. Successful treatment has usually consisted of surgical synovectomy in combination with high‐dose intravenous penicillin therapy. Multiple aspirations of affected joints as a definitive treatment should be used with caution and only in patients who are not candidates for surgery.
The importance of age, education, and comorbidity in the substantial earnings losses of individuals with symmetric polyarthritis
Authors: Mitchell Jean M. , Burkhauser Richard V. , Pincus Theodore 
Published: February 2007

AbstractA population‐based survey designed to be representative of the entire US population of working age (18–64 years) includes data on pain and swelling of specific joints in each subject. We analyzed these data to estimate work status and disability status, as well as earnings losses, associated with Symmetric Polyarthritis. Subjects identified in the survey as having Symmetric Polyarthritis were similar in age, race, sex, and marital status to rheumatoid arthritis patients seen in clinical settings. Overall, 51% of women with Symmetric Polyarthritis and 47% of men with Symmetric Polyarthritis were severely disabled, compared with 4.5% of women and 3.7% of men with no arthritis. Earnings of women and men with Symmetric Polyarthritis were only 27% and 48%, respectively, of earnings of individuals without arthritis. The total earnings gap between the 2 groups was 17.6 billion (1986 dollars). Econometric regression analyses indicated that about one‐third of this earnings gap was explained by the presence of Symmetric Polyarthritis. The remaining two‐thirds was explained by differences in age, education, and comorbidity between individuals with Symmetric Polyarthritis and those without arthritis. The earnings of individuals with Symmetric Polyarthritis, therefore, would be expected to be considerably lower than those of the general population, even if these individuals were not affected by arthritis. Nonetheless, earnings losses of at least 6.5 billion annually are explained by Symmetric Polyarthritis.
Dna sequence and conformation specificity of lupus autoantibodies. preferential binding to the left‐handed z‐dna form of synthetic polynucleotides
Authors: Thomas T. J. , Meryhew Nancy L. , Messner Ronald P. 
Published: February 2007

AbstractThe binding specificity of 16 sera from systemic lupus erythematosus (SLE) patients was studied by enzyme‐linked immunosorbent assay (ELISA), using 4 native DNAs of different guanine‐cytosine (G‐C) content and a group of synthetic polynucleotides. All the SLE sera showed increased binding to poly(dA‐dC)‐poly(dG‐dT), compared with calf thymus DNA in the right‐handed B conformation. No significant differences were noted in binding of selected SLE sera to the native DNAs that differed in G‐C content or superhelicity of DNA. With poly(dG‐dC).poly(dG‐dC) and poly(dG‐m5dC).poly(dG‐m5dC), the majority of SLE sera showed a preferential binding to the salt‐induced Z form, compared with the B form. In addition, an average twelve‐fold increase was found in binding to Z‐form brominated poly(dG‐dC).poly(dG‐dC) compared with B‐form poly(dG‐dC).poly(dG‐dC), when the polymers were coated on the plates in 0.15M NaCl. The preferential binding of SLE sera to poly(dA‐dC).poly(dG‐dT) and to Z‐DNA may be important in the formation of circulating immune complexes and subsequent vascular damage, or may provide a clue to the mechanism of production of anti‐DNA antibodies in this disease.
Renal vascular histology and morphometry in systemic sclerosis. a case–control autopsy study
Authors: Trostle David C. , Bedetti Carlos D. , Steen Virginia D. , Al‐Sabbagh M. Radwan , Zee Benny , Medsger Thomas A. 
Published: February 2007

AbstractAn autopsy case–control study of renal vascular histology and morphometry in systemic sclerosis (scleroderma) was performed. Thirty‐five of 70 systemic sclerosis cases had renal tissue available for study: 26 had diffuse cutaneous involvement (9 with “renal crisis” and 17 without) and 9 had limited cutaneous disease (CREST syndrome [calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, telangiectasias]). Age‐matched (within 10 years) and sex‐matched controls with renal specimens were obtained. New sections were cut from tissue blocks, and morphometry was completed using a Zeiss Image Analyzer. Using analysis of variance, the intimal area (Ai) was significantly increased (intimal thickening) in small and medium‐sized arteries of patients with diffuse scleroderma and in small arteries of CREST patients, compared with those in controls, while a decreased medial area (Am) was seen consistently in all groups. The proportion of the vessel wall occupied by intima (Ai:[Ai + Am]) was significantly greater in all vessel size groups in patients with diffuse scleroderma compared with that in controls. The percentage of luminal occlusion was greatest in patients with diffuse disease with renal crisis. These same patients had severe edematous and mucinous intimal thickening in small and medium vessels, often in association with fibrinoid necrosis. We conclude that renal vascular structural changes are an integral part of systemic sclerosis. However, the significant differences between diffuse scleroderma patients and CREST syndrome patients, for both intimal thickening and percentage of luminal occlusion, suggest that the arterial disease in these 2 patient subsets is distinctive.
Cyclophosphamide‐induced bladder toxicity in wegener's granulomatosis
Authors: Stillwell Thomas J. , Benson Ralph C. , Deremee Richard A. , Mcdonald Thomas J. , Weiland Louis H. 
Published: February 2007

AbstractIn a series of 111 patients with Wegener's granulomatosis who were given cyclophosphamide therapy, hemorrhagic cystitis, diagnosed on the basis of gross hematuria or at cystoscopy (or both), developed in 17 (15%). Most of these patients recovered uneventfully, with or without the discontinuation of cyclophosphamide, but 4 patients suffered a significant loss of blood, and bladder carcinoma developed in 3. New microhematuria also occurred in 52 patients (47%). The dose and duration of cyclophosphamide were greater in the group that had urotoxicity. Long‐term followup of patients with hemorrhagic cystitis is mandatory for the detection of late recurrences or the development of bladder malignancy. New therapies are being directed at protecting the bladder from urotoxicity during cyclophosphamide treatment.
Two ro (ss‐a) autoantibody responses in systemic lupus erythematosus
Authors: Hamilton Robert G. , Harley John B. , Bias Wilma B. , Roebber Marianne , Reichlin Morris , Hochberg Marc C. , Arnett Frank C. 
Published: February 2007

AbstractAutoantibodies to Ro (SS‐A), La (SS‐B), and Sm/nuclear RNP were quantitated by enzyme‐linked immunosorbent assay in 106 white patients with systemic lupus erythematosus. Two Ro autoantibody subgroups were identified that differed quantitatively, genetically, and clinically. The subgroup having anti‐Ro only demonstrated significantly lower mean anti‐Ro levels than did the subgroup with concomitant anti‐La and showed a strong association with the linked HLA alleles DR2 and DQw1. The anti‐Ro with anti‐La sub‐group was associated with the linked HLA alleles B8, DR3, DRw52, and DQw2 (DR3 was primary), and this subgroup consisted of patients with older ages at disease onset, sicca complex, and less renal involvement. Overall, the relative risk (RR) for having anti‐Ro was highest in HLA‐DR2/DR3 heterozygotes compared with non‐DR2/DR3 heterozygotes (RR 15) and all other DR combinations (RR 7), suggesting a compound effect of 2 immune responses. Heterozygotes for HLA‐DQw1/DQw2 demonstrated significantly higher mean levels of anti‐Ro, which may be indicative of trans gene interaction at HLA‐DQ. These data suggest the hypothesis that HLA genes exert their major effects on Ro/La autoantibody subsets of systemic lupus erythematosus.
Antibody to threonyl–transfer rna synthetase in myositis sera
Authors: Targoff Ira N. , Arnett Frank C. , Reichlin Morris 
Published: February 2007

AbstractThe prevalence and clinical correlations of antithreonyl–transfer RNA synthetase (anti–PL‐7), as well as the relationship of anti–PL‐7 to anti–histidyl–transfer RNA synthetase (anti–Jo‐1) were studied in 109 sera from patients with myositis. Inhibition of threonine aminoacylation was used to screen for anti–PL‐7. Sera from 3 patients, 2 with polymyositis and 1 with polymyositis–overlap syndrome, and a fourth serum from a patient with dermatomyositis, which was previously found to contain anti–PL‐7, inhibited >90% of activity (3.7% of 109 sera). All 4 sera reacted strongly in an enzyme‐linked immunosorbent assay with enzyme that was either affinity purified with anti–PL‐7 or was biochemically purified. There was no indication of cross‐reactivity by aminoacylation inhibition or, for most sera, by enzyme‐linked immunosorbent assay. Anti–PL‐7 is an uncommon myositis‐associated antibody that is independent of anti–Jo‐1, but is directed at a functionally related enzyme.
Progressive depletion of hyaluronic acid in early experimental osteoarthritis in dogs
Authors: Manicourt Daniel Henri , Pita Julio Cesar 
Published: February 2007

AbstractThe hyaluronic acid (HA) content of articular cartilage was studied in early experimental osteoarthritis (OA) in 16 normal dogs. The anterior cruciate ligament in the right knees of the dogs was transected; their left knees served as sham operated controls. The animals were killed at 7 and 14 weeks postsurgery. Although their total hexuronate, and thus proteoglycan, content remained unaltered during the period of study, the different weight‐bearing areas of the OA knees displayed a progressive and significant decrease in HA content. We found no differences in the molecular weight and in vitro aggregating capacity of the HA molecules from OA cartilage versus those from control cartilage. This early relative depletion of HA could contribute significantly to the biochemical alterations of OA cartilage. Furthermore, it appears to be a good parameter for the differentiation of changes related to OA and changes related to aging.
Identification of cartilage matrix glycoprotein in synovial fluid in human osteoarthritis
Authors: Fife Rose S. 
Published: February 2007

AbstractCartilage matrix glycoprotein (CMGP) is a high molecular weight protein found in hyaline cartilage and fibrocartilage. It consists of disulfide‐bonded subunits, each with an apparent molecular weight of 116, 000. Fragmentation of CMGP is noted in extracts of osteoarthritic canine cartilage. CMGP has been identified in the serum and synovial fluid of dogs with experimentally induced osteoarthritis. It has now been identified in synovial fluid from osteoarthritic human joints, but not in synovial fluid from joints of patients with other arthritides or joint abnormalities. The possible significance of CMGP in synovial fluid in human osteoarthritis is discussed.
Polymyalgia rheumatica: a syndrome associated with hla–dr4 antigen
Authors: Cid Maria‐Cinta , Ercilla Guadalupe , Vilaseca Jaume , Sanmarti Raimon , Villalta Jaume , Ingelmo Miguel , Urbano‐Marquez Alvaro 
Published: February 2007

AbstractHLA class II antigens were determined in 65 patients with biopsy‐proven giant cell arteritis (GCA). An increase in DR4 antigen frequency was found in the patients (40%) compared with that in 200 healthy controls (20%) (Pcorr < 0.05). DR4 was significantly more frequent in GCA patients with polymyalgia rheumatica (PMR) than in those without PMR (58.8% versus 19.3%) (P < 0.005). HLA–DR4 frequency in GCA patients without PMR was similar to that in the control population (20%). Patients with severe, disabling PMR had DR4 more frequently (90%) than did those with moderate symptoms who required medical care because of cranial arteritis manifestations (41.6%) (P < 0.05). We conclude that, in GCA patients, association with DR4 is mainly related to the manifestation of the disease as PMR. We discuss clinical and immunogenetic similarities between PMR and other DR4‐associated rheumatic disorders. Common immunopathogenic mechanisms leading to clinical overlap among them are suggested.
Use of t cell cloning to detect in vivo mutations induced by cyclophosphamide
Authors: Palmer Robert G. , Smith‐Burchnell Caroline A. , Pelton Bryan K. , Hylton Winsome , Denman A. Michael 
Published: February 2007

AbstractBy cloning T cells, mutations at the hypoxanthine‐guanine phosphoribosyltransferase locus were quantified in peripheral blood lymphocytes of 12 patients with connective tissue diseases receiving long‐term cyclophosphamide. Frequency of mutation was higher than in control subjects and was related to the duration of therapy; therefore, some cells with mutations are long‐lived, and these cells accumulate in the peripheral circulation. Mutation frequency was also independently related to age. The results indicate that even low doses of cyclophosphamide are mutagenic and may explain, in part, why these patients are at risk of drug‐induced malignancy.
Repeat radiation synovectomy with dysprosium 165—ferric hydroxide macroaggregates in rheumatoid knees unresponsive to initial injection
Authors: Vella Michael , Zuckerman Joseph D. , Shortkroff Sonya , Venkatesan Prasanna , Sledge Clement B. 
Published: February 2007

AbstractBecause of failure to fully respond to an initial intraarticular injection of dysprosium 165–ferric hydroxide macroaggregates, 17 patients with seropositive rheumatoid arthritis underwent repeat radiation synovectomy using this agent. Of the 13 patients who were evaluated 1 year later, 54% (7 knees) had good results, 31% (4 knees) had fair results, and 15% (2 knees) had poor results. The initial lack of significant benefit from radiation synovectomy did not appear to preclude a favorable response to a second injection.