bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improved Synthesis of 1‐Hydroxy‐2,2,5,5‐tetramethyl‐3‐imidazoline 3‐Oxide (HTIO).
Authors: Polienko Julya F. , Schanding Thomas , Voinov Maxim A. , Grigor'ev Igor A. 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Efficient Room‐Temperature Synthesis of Tri‐ and Tetrasubstituted Imidazoles Catalyzed by ZrCl4.
Authors: Sharma G. V. M. , Jyothi Y. , Lakshmi P. Sree 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Expeditious Approach to Coumarins via Pechmann Reaction Catalyzed by Molecular Iodine or AgOTf.
Authors: Wu Jie , Diao Tianning , Sun Wei , Li Yizhe 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis and Antimicrobial Activity of Pyranobenzoquinones Related to the Pyranonaphthoquinone Antibiotics.
Authors: Lagorio S. H. , Bianchi D. A. , Sutich E. G. , Kaufman T. S. 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Electrophilic Aromatic Substituted Luciferins as Bioluminescent Probes for Glutathione S‐Transferase Assays.
Authors: Zhou Wenhui , et al. et al. 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Cooperative Coexistence: Effective Interplay of Two Broensted Acids in the Asymmetric Synthesis of Isoquinuclidines.
Authors: Rueping Magnus , Azap Cengiz 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis and Biological Study of 4‐Aminopyrimidine‐5‐carboxaldehyde Oximes as Antiproliferative VEGFR‐2 Inhibitors.
Authors: Huang Shenlin , Li Ronghua , Connolly Peter J. , Xu Guozhang , Gaul Michael D. , Emanuel Stuart L. , LaMontagne Kenneth R. , Greenberger Lee M. 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Adamantane 11‐β‐HSD‐1 Inhibitors: Application of an Isocyanide Multicomponent Reaction.
Authors: Link J. T. , et al. et al. 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Four New Pregnane Glycosides from the Stems of Marsdenia tenacissima.
Authors: Wang Xiao‐Ling , Li Qi‐Fa , Yu Kai‐Bei , Peng Shu‐Lin , Zhou Yan , Ding Li‐Sheng 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of New Dehydro 2‐Azatryptophans and Derivatives via Heck Cross‐Coupling Reactions of 3‐Iodoindazoles with Methyl 2‐(Acetylamino)acrylate.
Authors: Crestey Francois , Collot Valerie , Stiebing Silvia , Rault Sylvain 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Genotoxic Activity of Halogenated Phenylglycine Derivatives.
Authors: Boto Alicia , Gallardo Juan A. , Hernandez Rosendo , Ledo Francisco , Munoz Ana , Murguia Jose R. , Menacho‐Marquez Mauricio , Orjales Aurelio , Saavedra Carlos J. 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Simple Analogues of Acyclonucleosides: Synthesis of N‐Substituted Pyrido[3′,2′:4,5]thieno[3,2‐d]pyrimidine Derivatives.
Authors: Khattab Ahmed F. , Zahran Magdy A. , Saif Ahmed 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Efficient Synthesis of New Nucleoside Analogues with a Methylenecyclobutane Unit.
Authors: Danappe Sophie , Boeda Fabien , Alexandre Christian , Aubertin Anne‐Marie , Bourgougnon Nathalie , Huet Francois 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Americanin, a Bioactive Dibenzylbutyrolactone Lignan, from the Seeds of Centaurea americana.
Authors: Shoeb Mohammad , MacManus Stephen M. , Kumarasamy Yashodharan , Jaspars Marcel , Nahar Lutfun , Thoo‐Lin Paul Kong , Nazemiyeh Hossein , Sarker Satyajit D. 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Total Synthesis of the Hydroxyketone Kurasoin A Using Asymmetric Phase‐Transfer Alkylation.
Authors: Andrus Merritt B. , Hicken Erik J. , Stephens Jeffrey C. , Bedke D. Karl 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Alternative Synthesis of Cystothiazole A.
Authors: Akita Hiroyuki , Sutou Noriyuki , Sasaki Takamitsu , Kato Keisuke 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Yaequinolones, New Insecticidal Antibiotics Produced by Penicillium sp. FKI‐2140. Part 2. Structural Elucidation.
Authors: Uchida Ryuji , Imasato Rie , Tomoda Hiroshi , Omura Satoshi 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Talosins A and B: New Isoflavonol Glycosides with Potent Antifungal Activity from Kitasatospora kifunensis MJM341. Part 2. Physicochemical Properties and Structure Determination.
Authors: Kim Won‐Gon , Yoon Tae Mi , Kwon Hyung Jin , Suh Joo Won 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Tetrahydroisoquinoline PPARγ Agonists: Design of Novel, Highly Selective Non‐TZD Antihyperglycemic Agents.
Authors: Henry James R. , et al. et al. 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Developments in the Chemistry of Selenaheterocyclic Compounds of Practical Importance in Synthesis and Medicinal Biology
Authors: Mlochowski Jacek , Kloc Krystian , Lisiak Rafal , Potaczek Piotr , Wojtowicz Halina 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Catalytic C—C Bond Formation in Natural Products Synthesis. Highlights from the Years 2000—2005
Authors: Hong Bor‐Cherng , Nimje Roshan Y. 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Rhodium(II)‐Catalyzed Reaction of Diazo Compounds in the Service of Organic Synthesis of Natural and Non‐Natural Products
Authors: Wee Andrew G. H. 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
State‐of‐Art Methodology of Marine Natural Products Chemistry: Structure Determination with Extremely Small Sample Amounts
Authors: Murata M. , Oishi T. , Yoshida M. 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Overexpression of CXCR4 predicts adverse overall and event‐free survival in patients with unmutated FLT3 acute myeloid leukemia with normal karyotype
Authors: Konoplev Sergej , Rassidakis Georgios Z. , Estey Elihu , Kantarjian Hagop , Liakou Chrysoula I. , Huang Xuelin , Xiao Lianchun , Andreeff Michael , Konopleva Marina , Medeiros L. Jeffrey 
Published: February 2007

AbstractBACKGROUND.CXC chemokine receptor 4 (CXCR4) expression in acute myeloid leukemia (AML) is reported to correlate with FLT3 gene mutation and poorer prognosis. The prognostic significance of CXCR4 expression in patients with AML that have a normal karyotype and no evidence of FLT3 gene mutations was examined.METHODS.The prognostic significance of CXCR4 expression in 122 AML patients with normal karyotype and no evidence of FLT3 gene mutation treated at our institution between 1997 and 2003 was analyzed. All patients received intensive chemotherapy according to institutional protocols; 84% received cytarabine‐containing regimens. Bone marrow biopsy or clot specimens obtained before treatment were immunostained for CXCR4.RESULTS.There were 70 men and 52 women with a median age of 62 years (range, 22–82 years). Median follow‐up was 18 months (range, <1–97 months). Seventy‐six patients achieved complete remission (CR); 39 had recurrence. Sixty‐six patients died, including 9 with no evidence of disease. CXCR4 was positive in 70 and negative in 52 patients, with CR rates of 58% and 71%, respectively (P = .09). Multivariate analysis demonstrated that CXCR4 expression, presence of multilineage dysplasia, and high creatinine level predicted poorer overall (OS) and event‐free (EFS) survival.CONCLUSIONS.The results suggest that CXCR4 expression is associated with poor prognosis in AML patients with an unmutated FLT3 gene. Cancer 2007. © 2007 American Cancer Society.
Therapeutic radiation for lymphoma
Authors: Teta M. Jane , Lau Edmund , Sceurman Bonnielin K. , Wagner Meghan E. 
Published: February 2007

AbstractBACKGROUNDIonizing radiation has been used since the 1950s to treat a variety of cancers. Cancer patients who are treated with radiotherapy have shown increased risks for a variety of second malignancies, including mesothelioma, in several recent reports. The only existing study of Hodgkin lymphoma (HL) and subsequent mesothelioma had a short observation period.METHODSThe authors used Surveillance, Epidemiology, and End Results data over a 30‐year period to identify patients with HL and non‐Hodgkin lymphoma (NHL) who also were diagnosed with mesothelioma. Standardized incidence ratios (SIR) and absolute excess risks were calculated by sex and treatment modality for both types of lymphoma.RESULTSTwenty‐six patients were identified who had mesothelioma as second primaries based on 21,881 diagnoses of HL and 101,001 diagnoses of NHL. There was a statistically significant increase in mesothelioma (4 diagnoses; SIR, 6.59; 95% confidence interval [95% CI], 1.79–16.87) among men with HL who received radiation, but no women survivors were identified who had a diagnosis of mesothelioma. For NHL survivors, there was a nonsignificant excess of mesothelioma among men (SIR, 1.91; 95% CI, 0.77–3.93) and women (SIR, 3.75; 95% CI, 0.77–10.95) who had received radiation treatment. There were no increases among patients who were unirradiated.CONCLUSIONSMesothelioma rates for patients who had received radiotherapy were increased for survivors of HL and NHL. No increases were observed among the unirradiated. These findings and the existing body of supporting studies confirmed that radiotherapy is a cause of mesothelioma. Cancer 2007. © 2007 American Cancer Society.
Periodic group edge crack problem of half‐plane in antiplane elasticity
Authors: Chen Y. Z. , Wang Z. X. , Li F. L. 
Published: February 2007

AbstractUsing complex variable function, an elementary solution of a single‐edge crack problem for half‐plane is proposed. The elementary solution is obtained by distributing the dislocation density along the prospective place of crack, and it is composed of the principal part and the complementary part. Based on the elementary solution and the principle of superposition, a system of Cauchy singular integral equations for periodic group edge crack problems of half‐plane in antiplane elasticity can be formulated. In the solution of the singular integral equation, the influences of many neighbouring groups on the central group are evaluated exactly. In addition, the influences on the central group by the many remote groups are considered approximately. By using a semi‐open quadrature rule, the singular integral equations are solved and the stress intensity factors at the crack tips are evaluated. Several numerical examples are given. Copyright © 2007 John Wiley & Sons, Ltd.
Fine‐needle aspiration cytology of a membranous basal cell adenoma arising in an intraparotid lymph node
Authors: López José I. , Ballestin Claudio 
Published: February 2007

AbstractThe so‐called membranous basal cell adenoma is a rare subtype of monomorphic adenomas that usually presents in the parotid gland. The cytologic, histologic, and immunohistochemical findings of an example of this entity, arising in an intraparotid lymph node of a 75‐yr‐old woman, are reported. Only 7 cases of this tumor have been published in such a peculiar location. As far as we know, fine‐needle aspiration cytology has never been performed.
High T‐helper‐1 cytokines but low T‐helper‐3 cytokines, inflammatory cytokines and chemokines in children with high risk of developing type 1 diabetes
Authors: Stechova Katerina , Bohmova Kristyna , Vrabelova Zuzana , Sepa Annelie , Stadlerova Gabriela , Zacharovova Klara , Faresjö Maria 
Published: February 2007

AbstractBackgroundType 1 diabetes (T1D) is suggested to be of T‐helper (Th)1‐like origin. However, recent reports indicate a diminished interferon (IFN)‐γ secretion at the onset of the disease. We hypothesize that there is a discrepancy in subsets of Th‐cells between children with a high risk of developing T1D, children newly diagnosed with T1D and healthy children.MethodsPeripheral blood mononuclear cells (PBMC) were collected from children at high risk for T1D (islet cells antibodies [ICA] ≥ 20 IJDF‐U), those newly diagnosed and healthy children carrying the HLA‐risk gene DQB1*0302 or DQB1*0201 and DQA1*0501. Th1‐ (IFN‐γ, tumour necrosis factor [TNF]‐β, interleukin [IL]‐2), Th2‐ (IL‐4,‐5,‐13), Th3‐ (transforming growth factor [TGF‐β], IL‐10) and inflammatory associated cytokines (TNF‐α, IL‐1α,‐6) and chemokines (monocyte chemoattractant protein [MCP]‐1,‐2,‐3, Monokine unregulated by IFN‐γ [MIG], Regulated on Activation, Normal T‐cell Expressed and Secreted [RANTES], IL‐7,‐8,‐15) were detected in cell‐culture supernatants of PBMC, stimulated with glutamic acid decarboxylase 65 (GAD65) and phytohaemagglutinin (PHA), by protein micro array and enzyme linked immunospot (ELISPOT) technique.ResultsThe Th1 cytokines IFN‐γ and TNF‐β, secreted both spontaneously and by GAD65‐ and mitogen stimulation, were seen to a higher extent in high‐risk children than in children newly diagnosed with T1D. In contrast, TNF‐α and IL‐6, classified as inflammatory cytokines, the chemokines RANTES, MCP‐1 and IL‐7 as well as the Th3 cytokines TGF‐β and IL‐10 were elevated in T1D children compared to high‐risk children.ConclusionHigh Th‐1 cytokines were observed in children with high risk of developing TID, whereas in children newly diagnosed with T1D Th3 cytokines, inflammatory cytokines and chemokines were increased. Thus, an inverse relation between Th1‐like cells and markers of inflammation was shown between children with high risk and those newly diagnosed with T1D. Copyright © 2007 John Wiley & Sons, Ltd.
Comparison of the anti‐diabetic effects of GIP‐ and GLP‐1‐receptor activation in obese diabetic (ob/ob) mice: studies with DPP IV resistant N‐AcGIP and exendin(1–39)amide
Authors: Irwin Nigel , McClean Paula L. , Cassidy Roslyn S. , O'Harte Finbarr P. M. , Green Brian D. , Gault Victor A. , Harriott Patrick , Flatt Peter R. 
Published: February 2007

AbstractBackgroundThe two major incretin hormones, glucose‐dependent insulinotropic polypeptide (GIP) and glucagon‐like peptide‐1 (GLP‐1) are being actively explored as anti‐diabetic agents because they lower blood glucose through multiple mechanisms. The rapid inactivation of GIP and GLP‐1 by the ubiquitous enzyme, dipeptidyl peptidase IV (DPP IV) makes their biological actions short‐lived, but stable agonists such as N‐acetylated GIP (N‐AcGIP) and exendin(1‐39)amide have been advocated as stable and specific GIP and GLP‐1 analogues.MethodsThe present study examined the sub‐chronic (14 days) anti‐diabetic actions of single daily doses of N‐AcGIP and exendin(1‐39)amide given alone or in combination to obese diabetic (ob/ob) mice over a 14‐day period.ResultsInitial experiments confirmed the potent anti‐hyperglycaemic and insulinotropic properties of N‐AcGIP and exendin(1‐39)amide. Sub‐chronic administration of N‐AcGIP alone or in combination with exendin(1‐39)amide significantly decreased non‐fasting plasma glucose and improved glucose tolerance compared to control ob/ob mice. This was associated with a significant enhancement of the insulin response to glucose and a notable improvement of insulin sensitivity. Combined treatment with N‐AcGIP and exendin(1‐39)amide also significantly decreased glycated haemoglobin. Exendin(1‐39)amide alone had no significant effect on any of the metabolic parameters monitored. In addition, no significant effects were observed on body weight and food intake in any of the treatment groups.ConclusionsThe results illustrate significant anti‐diabetic potential of N‐AcGIP alone and in combination with exendin(1‐39)amide. Copyright © 2007 John Wiley & Sons, Ltd.
Mixed primary culture and clonal analysis provide evidence that NG2 proteoglycan‐expressing cells after spinal cord injury are glial progenitors
Authors: Yoo Soonmoon , Wrathall Jean R. 
Published: February 2007

AbstractNG2+ cells in the adult rat spinal cord proliferate after spinal cord injury (SCI) and are postulated to differentiate into mature glia to replace some of those lost to injury. To further study these putative endogenous precursors, tissue at 3 days after SCI or from uninjured adults was dissociated, myelin partially removed and replicate cultures grown in serum‐containing or serum‐free medium with or without growth factors for up to 7 days in vitro (DIV). Cell yield after SCI was 5–6 times higher than from the normal adult. Most cells were OX42+ microglia/macrophages but there were also more than twice the normal number of NG2+ cells. Most of these coexpressed A2B5 or nestin, as would be expected for glial progenitors. Few cells initially expressed mature astrocyte (GFAP) or oligodendrocyte (CC1) markers, but more did at 7 DIV, suggesting differentiation of glial precursors in vitro. To test the hypothesis that NG2+ cells after SCI express progenitor‐like properties, we prepared free‐floating sphere and single cell cultures from purified suspension of NG2+ cells from injured spinal cord. We found that sphere cultures could be passaged in free‐floating subcultures, and upon attachment the spheres clonally derived from an acutely purified single cell differentiated into oligodendrocytes and rarely astrocytes. Taken together, these data support the hypothesis that SCI stimulates proliferation of NG2+ cells that are glial progenitor cells. Better understanding the intrinsic properties of the NG2+ cells stimulated by SCI may permit future therapeutic manipulations to improve recovery after SCI. © 2007 Wiley Periodicals, Inc. Develop Neurobiol, 2007.
5‐HT2 receptors in Drosophila are expressed in the brain and modulate aspects of circadian behaviors
Authors: Nichols Charles D. 
Published: February 2007

AbstractDysregulation of 5‐HT2 receptor function has been strongly implicated in many neuropsychiatric disorders, including schizophrenia. At present, the molecular mechanisms linking 5‐HT2 receptor activation to behaviors is not well understood. In efforts to elucidate these processes, the fruit fly, Drosophila melanogaster, is proposed to serve as a powerful genetically tractable model organism to study 5‐HT2 receptor function. Data are presented here on the expression of the fly ortholog of the mammalian 5‐HT2 receptor, 5‐HT2Dro, in the larval and adult brain of the fly, and on the involvement of these circuits in certain circadian behaviors. In the adult brain, 5‐HT2Dro is expressed in the protocerebrum and ellipsoid body, areas believed to participate in higher order behaviors including learning, locomotion, and sensory perception. In the third instar larva, 5‐HT2Dro receptor expression is detected in a specific pattern that markedly changes from early to late third instar. To probe the function of this receptor we have examined the effects of the 5‐HT2 receptor‐specific agonist DOI in wild type and 5‐HT2Dro hypomorphic flies on circadian behaviors. DOI was found to increase early day activity, eliminate anticipatory behavior, and reduce viability. The effects of DOI were significantly diminished in a 5‐HT2Dro hypomorphic strain. Identifying the 5‐HT2Dro receptor circuitry and behaviors they mediate are significant steps towards developing this model system to study conserved molecular mechanisms underlying behaviors mediated by 5‐HT2 receptors in mammalian systems. © 2007 Wiley Periodicals, Inc. Develop Neurobiol, 2007.