bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Noninferiority Trial Comparing 2 Days vs 5 Days of Terlipressin and Ceftriaxone in Terms of 5-Day Rebleeding for Patients With Acute Gastroesophageal Variceal Hemorrhage
Authors: Lo Gin-Ho , Yeh Jen-Hao , Tseng Cheng-Hao , Chen Tzu-Haw , Tai Chi-Ming , Wang Wen-Lun , Lin Hui-Chen 
Published: March 2024

INTRODUCTION:
This trial was to shorten the duration of both vasoconstrictors and prophylactic antibiotics to only 2 days in the therapy of acute gastroesophageal variceal hemorrhage.

METHODS:
After successful endoscopic hemostasis of gastroesophageal variceal hemorrhage, eligible patients were randomized to receive terlipressin infusion 1 mg per 6 hours and ceftriaxone 1 g daily for 5 days (group A) or a similar regimen for 2 days (group B). Primary end points were very early rebleeding at 5 days, and secondary end points included 48-hour hemostasis, 42-day rebleeding, and hospitalization days.

RESULTS:
Group A comprised 48 patients, and group B comprised 52 patients. Both groups were comparable in the severity of liver disease. Forty-eight-hour initial hemostasis was 95.8% in group A and 100% in group B (P = 0.13). Very early rebleeding between 3 and 5 days occurred in 1 patient (2.1%) in group A and 2 patients (3.8%) in group B (P = 0.60). The difference was 1.8% and the 95% confidence interval was −1.31% to 2.08%, which demonstrated noninferiority. Forty-two-day rebleeding occurred in 5 patients (10.4%) in group A and 4 patients (7.7%) in group B (P = 0.63). The median hospitalization days were 8.5 ± 3.8 days in group A vs 5.6 ± 2.6 days in group B (P < 0.001).

DISCUSSION:
After successful endoscopic hemostasis of acute variceal bleeding, combination of 2-day terlipressin infusion and ceftriaxone therapy was not inferior to the 5-day regimen in terms of very early rebleeding, with the advantage of shortening hospitalization stay.
Analisa Lapisan Termoklin Musiman Di Perairan Indonesia (Studi Kasus Selat Malaka)
Authors: Hendra Hendra , Pranowo Widodo Setiyo , Umam Choirul , Azhari Ferian , Agustinus Agustinus 
Published: March 2024

The Malacca Strait is a strategic waterway for Indonesia as it serves as an international shipping route connecting East Asia with the Middle East and Europe. In addition, the Malacca Strait also has great potential for natural resources, such as oil and gas as well as fish and other marine products. This study aims to describe the Thermocline Layer in the Malacca Strait based on Marine Copernicus Data in 2020 with a depth of up to 1000 meters. The temperature data was visualized using ODV 5.5.2 software. The results of processing the Marine Copernicus Temperature Data in 2020 in the Malacca Strait with a depth of up to 1000 meters show that the thermocline boundary varies each season. In the western season, the thermocline boundary is at a depth between 11 meters to 131 meters, in the first transitional season, it is at a depth between 22 meters to 131 meters, in the eastern season, it is at a depth between 56 meters to 156 meters, and in the second transitional season, it is at a depth between 78 meters to 131 meters. Bagian Selat Malaka adalah perairan yang strategis bagi Indonesia karena menjadi jalur pelayaran internasional yang menghubungkan Asia Timur dengan Timur Tengah dan Eropa. Selain itu, Selat Malaka juga memiliki potensi sumber daya alam yang besar, seperti minyak dan gas bumi serta ikan dan hasil laut lainnya. Penelitian ini bertujuan untuk mengidentifikasi dan menganalisis Lapisan Termoklin di Perairan Selat Malaka berdasarkan Data Marine Copernicus tahun 2020 dengan kedalaman sampai 1000 meter. Data Temperatur diolah dan dianalisis menggunakan software ODV 5.5.2. Hasil pengolahan Data Temperatur Marine Copernicus tahun 2020 di Perairan Selat Malaka dengan kedalaman mencapai 1000 meter dengan batas termoklin setiap musim dimana pada Musim barat batas termoklin berada pada kedalaman antara 11 meter sampai dengan 131 meter, Musim Peralihan I batas termoklin berada pada kedalaman antara 22 meter sampai dengan 131 meter, Musim Timur batas termoklin berada peda kedalaman antara 56 meter sampai dengan 156 meter dan Musim Peralihan II batas termoklin berada pada kedalaman antara 78 meter sampai dengan 131 meter.
η-Ricci--Yamabe and *-η-Ricci--Yamabe solitons in Lorentzian para-Kenmotsu manifolds
Authors: Prasad Rajendra , Haseeb Abdul , Kumar Vinay 
Published: March 2024

Abstract
The main purpose of this paper is to study η-Ricci–Yamabe solitons (η-RYS) and

*

{*}

-η-Ricci–Yamabe solitons (

*

{*}

-η-RYS) in Lorentzian para-Kenmotsu n-manifolds (briefly,

(
LPK
)

n

{(\mathrm{LPK})_{n}}

). We study the curvature condition

R
.

S
=
0

{R.S=0}

and the cyclic parallel Ricci tensor in

(
LPK
)

n

{(\mathrm{LPK})_{n}}

admitting η-RYS. Furthermore, we study M-projectively flat and quasi-M-projectively flat Lorentzian para-Kenmotsu manifolds admitting

*

{*}

-η-RYS. Finally, we give two examples of Lorentzian para-Kenmotsu manifolds admitting η-RYS and

*

{*}

-η-RYS to verify some of our results.
Withaferin A alters the expression of microRNAs 146a-5p and 34a-5p and associated hub genes in MDA-MB-231 cells
Authors: Shuaib Mohd , Chaudhri Smriti , Kumar Shashank 
Published: March 2024

Abstract
Triple-negative breast cancer (TNBC) is a highly metastatic subtype of breast cancer. Due to the absence of obvious therapeutic targets, microRNAs (miRNAs) provide possible hope to treat TNBC. Withaferin A (WA), a steroidal lactone, possesses potential anticancer activity with lesser side effects. The present study identifies hub genes (CDKN3, TRAF6, CCND1, JAK1, MET, AXIN2, JAG1, VEGFA, BRCA1, E2F3, WNT1, CDK6, KRAS, MYB, MYCN, TGFβR2, NOTCH1, SIRT1, MYCN, NOTCH2, WNT3A) from the list of predicted targets of the differentially expressed miRNAs (DEMs) in WA-treated MDA-MB-231 cells using in silico protein–protein interaction network analysis. CCND1, CDK6, and TRAF6 hub genes were predicted as targets of miR-34a-5p and miR-146a-5p, respectively. The study found the lower expression of miR-34a-5p and miR-146a-5p in MDA-MB-231 cells, and further, it was observed that WA treatment effectively restored the lost expression of miR-34a-5p and miR-146a-5p in MDA-MB-231 cells. An anti-correlation expression pattern was found among the miR-34a-5p and miR-146a-5p and the respective target hub genes in WA-treated TNBC cells. In conclusion, WA might exert anti-cancer effect in TNBC cells by inducing miR-34a-5p and miR-146a-5p expressions and decreasing CCND1, CDK6, and TARF6 target hub genes in TNBC cells.
Antibacterial and dynamical behaviour of silicon nanoparticles influenced sustainable waste flax fibre-reinforced epoxy composite for biomedical application
Authors: Natrayan L. , Ameen Fuad , Chinta Neelima Devi , Teja Nalla Bhanu , Muthu G. , Kaliappan S. , Ali Saheb , Vadiveloo Ashiwin 
Published: March 2024

Abstract
This article explores the impact of nano-silica on the properties of woven flax fibre/epoxy composites. Using compression moulding, epoxy/flax/silica hybrid nanocomposites were produced. The nano-silica was dispersed in the epoxy matrix via ultrasonication at various weight ratios. A series of tests, including crack durability, dynamic mechanical analysis, and scanning electron microscopy, were conducted to evaluate the modified materials. Notably, a 3% nano-silica filler load resulted in a 54% and 57% improvement in initiation and transmission interfacial fracture toughness, respectively. Scanning electron microscope imaging confirmed that fibres pull out at the crack tip during initial debonding, accounting for the increased toughness. Dynamic mechanical analysis further revealed enhancements in mechanical properties. Moreover, the 3% nano-silica content led to less fibre pull-out, suggesting higher heat resistance than standard flax/epoxy composites. The material also demonstrated promising antimicrobial efficacy against gram-positive and gram-negative bacteria, offering a potential alternative to conventional antibiotics.
Eine kontrastive Untersuchung über das Raumerleben anhand von Berichten im chinesischen und deutschen Reisemagazin
Authors: Liang Shanshan , Zou Ziyuan 
Published: March 2024

Zusammenfassung
In der Humangeografie beschreiben das Ortsgefühl sowie das Raumgefühl die vergesellschafteten Beziehungen zwischen Menschen und Raum. Die beiden Gefühle können zusammen als Raumerleben bezeichnet werden. Wie das Raumerleben in konkreten Fällen zum Ausdruck kommt und inwiefern es mit bestimmten kulturellen Einflüssen präsentiert wird, sind für die interkulturelle Forschung interessante Fragestellungen. Das Raumerleben ist nämlich als kulturelles Erleben zu interpretieren. Somit zielt die vorliegende Untersuchung darauf ab, in Reiseberichten des deutschen Reisemagazins GEO SAISON und des chinesischen Reisemagazins TRENDS TRAVELER in Bezug auf die repräsentative Landschaft als „Ort“, räumliche Wahrnehmung und räumliche Wertvorstellung das jeweilige Raumerleben als kulturelles Erleben miteinander zu vergleichen und zu erforschen.
“I’ve just lived inside a tumble dryer”: a narrative of emotion labour, (de)motivation, and agency in the life of a language teacher
Authors: Banegas Darío Luis 
Published: March 2024

Abstract
Tensions between external sources of power and internal feeling rules in the workplace, i.e., emotion labour, can have a profound effect on professional dimensions. The purpose of this article is to report on a study that explored a secondary language teacher’s emotion labour and its influence on her professional (de)motivation and agency. Framed in narrative inquiry, this longitudinal study collected data through narrative interviews and drawings between February 2020 and March 2022. The participant was an EFL (English as foreign language) teacher who held teaching posts at three different state secondary schools and a private language centre in Argentina. During this period, the teacher grappled with emergency online teaching due to the Covid-19 pandemic and lengthy teacher strikes. Drawing on analysis of the short stories constructed from the narrative interviews, the tensions between external and internal feeling rules and their interplay with (de)motivation and agency are chronologically mapped out.
Realtime assessment of vascular occlusion and reperfusion in animal models of intraoperative imaging – a pilot study
Authors: Kandukuri Jayanth , Jain Aseem , Karmarkar Parag , Gadagkar Hrishikesh , Aberman Harold , Wang Qihong , Rege Abhishek 
Published: March 2024

Abstract

Objectives
Intraoperative monitoring of blood flow (BF) remains vital to guiding surgical decisions. Here, we report the use of SurgeON™ Blood Flow Monitor (BFM), a prototype system that attaches to surgical microscopes and implements laser speckle contrast imaging (LSCI) to noninvasively obtain and present vascular BF information in real-time within the microscope’s eyepiece.

Methods
The ability of SurgeON BFM to monitor BF status during reversible vascular occlusion procedures was investigated in two large animal models: occlusion of saphenous veins in six NZW rabbit hindlimbs and clipping of middle cerebral artery (MCA) branches in four Dorset sheep brain hemispheres. SurgeON BFM acquired, presented, and stored LSCI-based blood flow velocity index (BFVi) data and performed indocyanine green video angiography (ICG-VA) for corroboration.

Results
Stored BFVi data were analyzed for each phase: pre-occlusion (baseline), with the vessel occluded (occlusion), and after reversal of occlusion (re-perfusion). In saphenous veins, BFVi relative to baseline reduced to 5.2±3.7 % during occlusion and returned to 102.9±14.9 % during re-perfusion. Unlike ICG-VA, SurgeON BFM was able to monitor reduced BFVi and characterize re-perfusion robustly during five serial occlusion procedures conducted 2–5 min apart on the same vessel. Across four sheep MCA vessels, BFVi reduced to 18.6±7.7 % and returned to 120.1±27.8 % of baseline during occlusion and re-perfusion phases, respectively.

Conclusions
SurgeON BFM can noninvasively monitor vascular occlusion status and provide intuitive visualization of BF information in real-time to an operating surgeon. This technology may find application in vascular, plastic, and neurovascular surgery.
Boundary controllability for variable coefficients one-dimensional wave equation with interior degeneracy
Authors: Azzaoui Mohamed , Salhi Jawad , Tilioua Mouhcine 
Published: March 2024

Abstract
In this paper, we study boundary controllability for the linear extension problem of a wave equation with space-dependent coefficients and having an internal degeneracy. For this purpose, we mainly focus on the well-posedness and the boundary null controllability of a relaxed version of the original problem, namely, to some degenerate transmission problem. The key ingredient is to derive direct and inverse inequalities for the associated homogeneous degenerate adjoint problem. By these inequalities, we deduce that the transmission problem has a unique solution by transposition and this solution is null controllable. Moreover, we give an explicit formula of the controllability time.
Amitsur's theorem, semicentral idempotents, and additively idempotent semirings
Authors: Rachev Martin , Trendafilov Ivan 
Published: March 2024

Abstract
The article explores research findings akin to Amitsur’s theorem, asserting that any derivation within a matrix ring can be expressed as the sum of an inner derivation and a hereditary derivation. In most results related to rings and semirings, Birkenmeier’s semicentral idempotents play a crucial role. This article is intended for PhD students, postdocs, and researchers.
Pengaruh Komposisi Ekstrak Jambu Biji Merah terhadap Kualitas Jelly Drink
Authors: Fitriani Yunita , Zahrulianingdyah Atiek 
Published: March 2024

Tujuan penelitian ini adalah untuk 1) mengetahui pengaruh komposisi ekstrak buah jambu biji merah terhadap kualitas jelly drink jambu biji merah ditinjau dari aspek kejernihan warna, aroma, tekstur, rasa manis, dan rasa asam, 2) mengetahui komposisi ekstrak buah jambu biji merah yang tepat sehingga dapat menghasilkan jelly drink jambu biji merah yang berkualitas, 3) mengetahui kandungan vitamin C dan serat pada jelly drink jambu biji merah hasil eksperimen, 4) mengetahui kesukaan masyarakat terhadap kualitas jelly drink jambu biji merah hasil eksperimen ditinjau dari segi kejernihan warna, aroma, tekstur, rasa manis dan rasa asam. Teknik analisis data yang digunakan adalah analisis varian klasifikasi tunggal untuk menganalisis data uji inderawi, analisis deskriptif presentase untuk menganalisis uji kesukaan masyarakat dan untuk uji kandungan gizi dilakukan di laboratorium BBTPPI, Semarang. Hasil penelitian ini adalah ada perbedaan kualitas jelly drink pada aspek kejernihan warna, aroma, tekstur dan rasa. Dari segi kejernihan warna dapat disimpulkan semakin banyak penggunaan buah warna semakin baik. Aroma yang dihasilkan juga berbeda, semakin banyak penggunaan buah aroma semakin nyata. Untuk aspek tekstur hasil yang diperoleh semakin banyak jumlah buah maka tekstur akan semakin keras. Rasa manis yang dihasilkan cenderung sama namun untuk rasa asam semakin banyak penggunaan buah maka rasa akan semakin asam. Hasil uji kesukaan masyarakat yaitu sampel A disukai masyarakat, sampel B sangat disukai masyarakat, sampel C disukai masyarakat, sampel D disukai masyarakat. Kandungan vitamin C pada sampel A yaitu 138,21 mg, sampel B yaitu 150,40 mg, sampel C yaitu 162,61 mg. Kandungan serat kasar pada sampel A yaitu 0,06%, sampel B yaitu 0,09%, sampel C yaitu 0,10%.
The Effect Of Nutritional Literacy On The Adequacy Of Energy And Protein In Culinary Education Study Program Students At Semarang State University
Authors: Hanapi Roy , Fathonah Siti 
Published: March 2024

Abstract
The research objectives were 1) to determine the level of nutritional literacy in college students 2) to determine energy adequacy in college students 3) to determine protein adequacy in college students 4) to determine the effect of nutritional literacy on energy adequacy 5) to determine the effect of nutritional literacy on protein adequacy. This research was a survey research and a cross-sectional research design with research subjects being students of the Culinary Education Study Program, Semarang State University. Sampling used a saturated sampling technique in which all members of the population in this study were used as samples. The sample in this study was 81 students of the Culinary Education Study Program, Semarang State University, Class of 2021. Nutritional literacy is measured by The Nutrition Literacy Assessment Instrument (NLit). Energy and protein adequacy was measured using a food recall instrument for two days. Data analysis used percentage descriptive analysis for objectives 1-3 and simple linear regression for objectives 4-5. The results showed that the level of nutritional literacy on average was in the less category with a percentage of 63.4%. Energy adequacy shows an average value in the category of moderate level deficit with a percentage of 73%. Protein adequacy shows an average value in the mild deficit category with a percentage of 87.6%. The results of simple linear regression analysis showed that there was no significant effect between nutritional literacy and energy adequacy (p = 0.698) and there was no significant effect between nutritional literacy and protein adequacy (p = 0.812). These results indicate that students' understanding of nutritional literacy has not been able to fulfill proper nutritional adequacy.

Keywords: Nutritional literacy, energy adequacy, protein adequacy
Evaluation of the Implementation of Healthy Food Provision for Early Childhood at Muslimat Nu Puton Kindergarten in Pekalongan
Authors: Amin Moh. Hikam Istifaul , Wahyuningsih Wahyuningsih , Fathonah Siti , Sugeng Bambang 
Published: March 2024

Early Childhood Education in addition to providing educational services as well in the form of early childhood nutritional health services implemented through provision of a healthy and nutritionally balanced diet to help growth and support physical and spiritual development, as well as to help develop the potential for spiritual, intellectual, emotional and social intelligence in early childhood through the Provision of Healthy Food. The aims of this study were 1) to find out the mechanism for implementing healthy food at the Muslimat NU Puton Kindergarten in Pekalongan. 2) To find out the criteria for providing healthy food at the Muslimat NU Puton Kindergarten in Pekalongan. 3) To find out the extent of achievement in implementing healthy food at the Muslimat NU Puton Kindergarten in Pekalongan. The method used in this research is descriptive qualitative. Data collection techniques using interview techniques, observation, and documentation.
The results showed that 1) The implementation of healthy food for young children in Muslimat Kindergarten NU Puton Pekalongan is given once a week which is held every Thursday at 10.00 WIB for lunch for children after carrying out learning and playing activities, the menu given every week is different Different, namely in the form of healthy snacks/snacks and main meals so that children don't get bored of receiving healthy food at school. 2) The criteria for providing healthy food to children at the Muslimat NU Puton Pekalongan Kindergarten have not been fully implemented in accordance with the existing criteria, the criteria that have not been implemented are that in the process of making food for cooks they have not used personal protective equipment (PPE) and the food ingredients used have not been fully using local ingredients. 3) The achievement of implementing healthy food at the Muslimat NU Puton Kindergarten in Pekalongan seen from the aspect of increasing children's development according to their age stages, increasing children's weight and height, as well as parental involvement in parenting activities can be said to be successful.
Treatments for ADHD in Children and Adolescents: A Systematic Review
Authors: Peterson Bradley S. , Trampush Joey , Maglione Margaret , Bolshakova Maria , Rozelle Mary , Miles Jeremy , Pakdaman Sheila , Brown Morah , Yagyu Sachi , Motala Aneesa , Hempel Susanne 
Published: March 2024

CONTEXT
Effective treatment of attention-deficit/hyperactivity disorder (ADHD) is essential to improving youth outcomes.

OBJECTIVES
This systematic review provides an overview of the available treatment options.

DATA SOURCES
We identified controlled treatment evaluations in 12 databases published from 1980 to June 2023; treatments were not restricted by intervention content.

STUDY SELECTION
Studies in children and adolescents with clinically diagnosed ADHD, reporting patient health and psychosocial outcomes, were eligible. Publications were screened by trained reviewers, supported by machine learning.

DATA EXTRACTION
Data were abstracted and critically appraised by 1 reviewer and checked by a methodologist. Data were pooled using random-effects models. Strength of evidence and applicability assessments followed Evidence-based Practice Center standards.

RESULTS
In total, 312 studies reported in 540 publications were included. We grouped evidence for medication, psychosocial interventions, parent support, nutrition and supplements, neurofeedback, neurostimulation, physical exercise, complementary medicine, school interventions, and provider approaches. Several treatments improved ADHD symptoms. Medications had the strongest evidence base for improving outcomes, including disruptive behaviors and broadband measures, but were associated with adverse events.

LIMITATIONS
We found limited evidence of studies comparing alternative treatments directly and indirect analyses identified few systematic differences across stimulants and nonstimulants. Identified combination of medication with youth-directed psychosocial interventions did not systematically produce better results than monotherapy, though few combinations have been evaluated.

CONCLUSIONS
A growing number of treatments are available that improve ADHD symptoms and other outcomes, in particular for school-aged youth. Medication therapies remain important treatment options but are associated with adverse events.
Cumulative effect of arsenic on the number of mouse offspring and the female reproductive hormones in mice
Authors: Birinji Anita , Pogrmić-Majkić Kristina , Mihaljev Željko , Marin Marija , Lalošević Dušan 
Published: March 2024

AbstractIn this study, we evaluated the cumulative effects of arsenic (III) oxide on the number of mouse offspring over three consecutive generations and monitored changes in levels of the reproductive hormones, oestradiol and progesterone in female mice during the dioestrus phase of the cycle. The control group received water from the mains. In two experimental groups, mice were given drinking water containing dissolved arsenic (III) oxide at concentrations of 10.6 mg L−1 and 106 mg L−1, respectively. These concentrations represent the values converted from a human model to an animal model (mice) thus correspond to the arsenic content of the groundwater in the southern part of the Pannonian Basin, in the province of Vojvodina, in the Banat region, in particular in the town of Zrenjanin. The average number of newborn mice in both experimental groups decreased for three consecutive generations. The total arsenic content of day-old mice did not show significant differences between the experimental groups. Arsenic (III) oxide affected the reproductive hormone levels of female mice at both concentrations.