bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study on the measurement of the level of construction occupational health and safety management in prefabricated building: a case study of a practical training building
Authors: Liu Wei , Feng Zhongyi , Hu Yuehan , Luo Xiao 
Published: February 2025

PurposePrefabricated building (PB) has high technical requirements and is susceptible to safety accidents, and its construction occupational health and safety (OHS) problems should not be ignored. To promote the better development of PB, this study aims to measure their construction safety management level and propose corresponding countermeasures.Design/methodology/approachBy systematically combing the relevant literature, this study extracts the influencing factors that appear frequently in several studies and categorizes them according to six dimensions: people, materials and components, technology, mechanical equipment, environment and system. Combining expert opinions, the measurement index system, including 6 primary indexes and 24 secondary indexes, is constructed. The structural entropy weight (SEW) method is applied to calculate the index weights. The cloud matter element (CME) model based on the weights is constructed to determine the level of construction occupational health and safety management (COHSM). A project case of a training building is used to verify it. The results obtained from the model are compared with those from other measurement models to verify the feasibility of the model in measuring the level of COHSM for PB.FindingsThe calculated weights show that technology is the most important for the COHSM of PB. The management level of the project in terms of people, materials and components, technology, machinery and equipment, environment and system is Level II good. The overall safety management level is also Level II, which is good. The model of this study is consistent with other model measurements. The methodology of this study yields reasonable and realistic results.Originality/valueThis study is the first to include occupational health dimensions in the research on the construction safety management of PB, which not only covers the key elements in traditional construction safety management but also considers the impact of the construction process, material use and technology of PB on safety management, making the measurement index system more scientific. Meanwhile, the introduction of the CME model based on the SEW method effectively solves the deficiencies of the traditional method in dealing with ambiguity and uncertainty and provides practitioners with more accurate and comprehensive measurement results. It helps practitioners formulate a more scientific management plan in combination with the actual situation and provides a guiding idea and practical path for the COHSM of similar projects.
Harmonising derivatives with Shari’ah: ethical practices and regulatory insights
Authors: Alhejaili Mohammad 
Published: February 2025

Purpose
This study explores the ethical challenges of integrating derivatives into Islamic finance. It aims to reconcile the principles of Shari’ah law with modern financial practices. It seeks to understand how derivatives, characterised by their complexity and speculative nature, can align with Islamic moral values, ensuring financial stability and social equity.

Design/methodology/approach
Adopting a doctrinal legal research methodology, the investigation delves into primary and secondary sources encompassing the Quran, Hadith, contemporary scholarly articles, and regulatory documents. The approach enables a comprehensive analysis of Islamic legal texts and principles, assessing their applicability to derivatives within a framework emphasising Shari’ah compliance and ethical integrity.

Findings
The research identifies pathways for the ethical integration of derivatives in Islamic finance, highlighting the potential of these financial instruments to enhance economic justice and societal welfare when aligned with Shari’ah principles. It uncovers regulatory frameworks and innovative practices that can mitigate ethical dilemmas, ensuring derivatives contribute positively to the Islamic financial system.

Originality/value
This paper offers original insights into reconciling financial innovation with Islamic ethical mandates by applying a doctrinal legal research methodology to studying derivatives in Islamic finance. It contributes to the academic discourse on Islamic finance and ethics, providing a nuanced framework for developing Shari’ah-compliant derivative products that uphold the principles of risk-sharing, transparency and social equity. This investigation enriches the understanding of ethical practices in Islamic finance, proposing a model for balancing modern financial mechanisms with traditional Islamic values.
Unveiling the Metaverse retail environments: understanding consumer gratifications and buying behavior
Authors: Patil Kanchan Pranay , Paul Justin , Bharathi S Vijayakumar , Pramod Dhanya 
Published: February 2025

PurposeConsumers in a Metaverse have an immersive engagement with products and services. This study aims to explore the multidimensional features of the Metaverse that influence consumers’ usage and gratifications, leading to their purchase behavior.Design/methodology/approachThis study uses uses and gratifications theory to examine how hedonic, utilitarian and social gratifications influence Metaverse consumers’ retail behavior. Empirical analysis (N = 291) using structural equation modeling via SmartPLS and PLSpredict validated the model’s robustness and predictive accuracy.FindingsMetaverse retail authenticity and virtuality influenced hedonic gratifications; autonomy and virtuality affected social gratification. Hedonic and social gratifications drove purchases, while utilitarian gratification had no significant effect.Originality/valueThis study applies uses and gratification theory to identify Metaverse-specific motivation factors, contributing to literature and aiding the practical design and development of Metaverse retail environments.
Transformation as city brand attribute for Medellín, Colombia: bottom-up tourist destination brand strategy
Authors: Rojas-DeFrancisco Laura , Mejía-Gil Maria Claudia , Giraldo Aristizábal Juan Camilo 
Published: February 2025

Purpose
Medellín, Colombia, experienced a remarkable social transformation in just two decades, leaving behind its troubled past of violence and insecurity. This study aims to identify the key actors and initiatives contributing to this transformation, considering cultural and social values shaping residents’ and visitors’ perceptions and determining the potential for the city’s brand. The research uses identity-based place branding theory and Delphi rounds to compare expert and promoter perspectives through surveys and tourist insights. The findings reveal recognising having a transformation in mind having offers guidelines for residents to propose tourism initiatives, aiding strategic city promotion and brand-building in collaboration with various organisations.
Management Experience of T1 Glottic Cancer Treated by CO2 Laser Surgery: A Cohort of 173 Patients
Authors: Li Changjiang , Chen Jian , He Peijie , Cheng Lei , Wu Haitao 
Published: February 2025

ABSTRACTIt was aimed to explore an alternative solution to manage T1 glottic cancer patients. One hundred seventy‐three patients were enrolled. Seventy‐eight cases were treated with type I and proved to be microinvasion cancer. Of them, 21 willingly selected followed up and 57 were further undergone type II. Ninety‐five underwent type III and confirmed to be superficial invasion cancer in which Reinke's space was invaded. Five(23.8%), four(7.0%) and nine (9.5%)cases separately relapsed in type I, II and III. No significant difference was observed (p>0.05). 5/60, 5/11 and 8/102 patients respectively replaced in negative, positive and uncertain margin groups. There were remarkable differences among them (p<0.05). The recurrence rate is still low for patients with early glottic cancer undergone vocal cord resection using CO2 laser, and the appropriate surgical method should be selected for a diverse range of glottic cancer to avoid overtreatment. Patients with positive incisal margins have a relatively high recurrence rate and should take this situation seriously.
Hippocampal Subfield Volume in Relation to Cerebrospinal Fluid Amyloid‐ß in Early Alzheimer's Disease: Diagnostic Utility of 7T MRI
Authors: Adeyemi Oluwatobi F. , Gowland Penny , Bowtell Richard , Mougin Olivier , Hosseini Akram A. 
Published: February 2025

ABSTRACTIntroductionAlzheimer's disease (AD) is a neurodegenerative condition characterised by amyloid plaque accumulation and neurofibrillary tangles. Early detection is essential for effective intervention, but current diagnostic methods that enable early diagnosis in clinical practice rely on invasive or costly biomarker scanning. This study aimed to explore the utility of 7T MRI in assessing hippocampal subfield volumes and their correlation with cerebrospinal fluid (CSF) biomarkers in prodromal AD.MethodsFifty‐six participants, including AD patients and healthy controls, underwent 7T MRI scanning. Automated segmentation delineated hippocampal subfield volumes, with subsequent normalisation to whole brain volume.ResultsSignificant differences in hippocampal and subfield volumes were observed in prodromal AD patients, even when they did not exhibit high MTA scores on 3T MRI or show any whole brain volume loss. Additionally, the volume of the entorhinal cortex (ERC) correlated significantly with CSF amyloid‐β levels, suggesting ERC's potential as a proxy CSF amyloid‐ß measurement. Conversely, no significant associations were found between CSF 181‐Phosphorylated‐tau or total tau levels and any hippocampal subfield volumes.DiscussionThese findings show the potential use of 7T MRI, particularly in ERC assessment, as a biomarker for early AD identification. Further validation studies are warranted to confirm these results and elucidate the relationship of ERC volume with CSF biomarkers.
Is Tailored Bismuth Quadruple Therapies (With Clarithromycin or Furazolidone) Based on Fecal Molecular Susceptibility Testing in First‐Line Helicobacter pylori Eradication Treatment More Effective? A Three‐Arm, Multicenter Randomized Clinical Trial
Authors: Yu Zhengchen , Liu Xiaochen , Qiao Jincheng , Shen Wenjuan , Mao Xingwei , Lou Guochun , Li Yan , Xie Ziming , Ye Jun 
Published: February 2025

ABSTRACTBackgroundRising antimicrobial resistance has significantly challenged the eradication rates of Helicobacter pylori. Due to its invasive nature, susceptibility testing based on endoscopic biopsy is controversial, while few studies have focused on the efficacy of tailored bismuth quadruple therapies (BQT) based on fecal susceptibility testing as a first‐line treatment.MethodsIn this multicenter study, 598 H. pylori‐positive patients without previous eradication treatment were recruited and randomly assigned to three groups: empirical BQT, BQT‐tailored based on the history of clarithromycin use and tailored based on fecal molecular susceptibility testing where furazolidone was substituted for clarithromycin when there was clinical or laboratory evidence of clarithromycin resistance. This study defines BQT as regimens comprising rabeprazole, colloidal bismuth, amoxicillin, and one additional antibiotic (furazolidone or clarithromycin). The study assessed eradication rates using intention‐to‐treat (ITT), modified intention‐to‐treat (mITT), and per‐protocol (PP) analyses.ResultsThe eradication rates of three groups were 82.00%, 80.90%, and 87.44% in the ITT analysis; 82.41%, 83.42%, and 89.23% in the mITT analysis; and 85.86%, 87.50%, and 94.57% in the PP analysis, respectively. Tailored BQT based on fecal susceptibility testing was not inferior to empirical BQT (all p values for noninferiority < 0.001) and demonstrated greater efficacy in the PP analysis (difference [95% CI]: 7.07% [0.90%, 13.25%]). The incidence of adverse events and treatment compliance did not differ significantly among the groups.ConclusionTailored BQT based on fecal susceptibility testing is an effective regimen for H. pylori eradication, with no increase in adverse events or treatment noncompliance compared with empirical BQT. Therefore, we recommend tailored BQT based on fecal susceptibility testing as a first‐line treatment.Trial RegistrationEudraCT number: NCT05718609; ClinicalTrials.gov
Interceptive orthodontic treatment with elastodontic appliance for open bite in early childhood: a case series
Authors: Vena Filippo , D'Amico Giorgia , Cardarelli Filippo , Cianetti Stefano , Severino Marco 
Published: February 2025

This case series explores the effectiveness of interceptive orthodontic treatment using A.M.C.O.P elastodontic appliances for open bite correction in early childhood. The study included three patients aged 3-5 years with primary dentition open bite and associated oral habits, treated at the Odontostomatological Centre, University of Perugia. Treatment utilized A.M.C.O.P Bio-Activators, tailored for early intervention, leveraging light and biological elastic forces to guide jaw growth and correct dental alignment.
The study highlights the role of timely intervention using A.M.C.O.P Bio-Activators in managing malocclusions, demonstrating significant improvements in occlusion and functional disorders. Early treatment with these devices not only corrects open bite efficiently but also reduces the need for future orthodontic interventions, emphasizing the importance of accurate diagnosis and patient compliancein achieving lasting results.
Minimal invasive sinus elevation (MISE), a different approach for maxillary sinus lift surgery
Authors: Pizzolante Tommaso , Saggiomo Anna Pia , Principi Martina , Jorida Jubani , Mema Mattia , Jolla Ervis , Rastelli Sofia 
Published: February 2025

Aim: The maxillary sinus lift is a crucial surgical procedure performed to increase the vertical height of the remaining bone, often required before implant placement.
Several techniques are used to approach the maxillary sinus, with varying results.
Among them, it is possible to mention the minimal invasive sinus elevation (MISE)
technique.
Methods: This paper provides a comprehensive review of the MISE technique, its materials, and surgical methods. It analyzes the outcomes compared to conventional methods and discusses its applicability in different clinical scenarios.
Results: The MISE technique has proven effective in increasing bone height with a lower risk of membrane perforation compared to traditional methods. It offers high implant success rates and minimal post-operative complications, with strong patient outcomes regarding bone regeneration and implant stability. This section will analyze these results with both quantitative and qualitative evaluations.
Conclusions: The MISE technique notably improves sinus lift procedures, providing a minimally invasive method with reliable clinical results. Its predictability and lower risk of membrane perforation make it well-suited for implant surgeries involving sinus elevation. Future studies should explore long-term results and refine the technique for broader clinical use.
Isolation and characterization of
Plasmodium falciparum
blood-stage persisters by improved selection protocols using dihydroartemisinin alone
Authors: Kiboi Daniel , Sá Juliana M. , Nayak Akshaykumar , Micchelli Chiara E. , Amin Shuchi N. , Burbelo Alexander G. , Abielmona Sasha A. , Xi Brian , Mulei Lucia A. , Onchieku Noah M. , Percopo Caroline M. , Mu Jianbing , Wellems Thomas E. 
Published: February 2025

ABSTRACT

Artemisinin-based combination therapies (ACTs) are vital for malaria treatment, but these are threatened by blood-stage persisters—dormant forms of
Plasmodium
parasites that can survive drug exposure and cause recrudescent infections. Here, we present improved protocols for efficient preparation of pure
Plasmodium falciparum
persister populations without the need for magnetically activated columns, sorbitol exposure, or prolonged manipulations. Our protocols transformed actively replicating parasites into persister populations by exposing mixed blood-stage parasites to three or four consecutive daily 6 h pulses of 700 nM or 200 nM dihydroartemisinin (DHA). In micrographs of Giemsa-stained cells, we observed different persister morphologies: Type I persisters containing a rounded magenta-stained nucleus accompanied by a local region of blue-stained cytoplasm; and the more-prevalent Type II persisters characterized by a dark round or irregular-appearing nucleus and faded or no detectable cytoplasm. We also observed cells with disorganized nuclear and cytoplasmic structure, suggesting possible autophagic processes of destruction and remodeling. Recrudescence of actively replicating parasites to starting parasitemia or higher occurred around 17–22 days after initial DHA exposure. Differential expression patterns of the acetyl CoA carboxylase (
acc
) and skeleton binding protein 1 (
sbp1
) genes during DHA treatment, dormancy, and recrudescence highlighted the evolution of physiologic states and metabolic changes underlying persister formation and recovery. Our findings suggest hypotheses and questions for further research to understand the cellular pathways of dormancy and uncover strategies to thwart parasite survival after drug exposure.
Profiles of developmental disorder and associations with gestational age
Authors: Pettinger Katherine Jane , Blower Sarah Louise , Boyle Elaine M , Hewitt Catherine Elizabeth , Fraser Lorna K 
Published: February 2025

ObjectiveThis study aimed to examine profiles of co-occurrence of developmental disorders and their association with birth before full term.DesignLatent class analysis of cohort data with linked health data.SettingBradford, England.Patients13 172 children were included in the analysis.Outcome measuresDevelopmental disorder in medical records.MethodsData were censored at each child’s 12th birthday. The latent class analysis identified patterns of developmental disorders. Multinomial logistic regression explored the association with gestational age while adjusting for clinical and socio-factors.ResultsThe majority (12,536) had a low risk of developmental disorders; this group was named ‘typical development’. The remaining children were classified into three groups: ‘educational difficulties’ (347 children); ‘social, emotional, behavioural and communication difficulties’ (189 children) and ‘early developmental impairment, with physical and intellectual disabilities’ (100 children).Compared with ‘typical development’, very preterm birth was associated with an increased likelihood of being in the ‘early developmental impairment, with physical and intellectual disabilities’ group, adjusted relative risk ratio (aRRR): 9.22 (95% CI 4.58 to 18.55). Birth before full term was associated with increased likelihood of being in the ‘educational difficulties’ group; risk was highest <34 weeks (aRRR: 2.64 (95% CI 1.44 to 4.83)) but persisted up to 37–38 weeks: aRRR: 1.41 (95% CI 1.10 to 1.81). There was no association between gestational age and the ‘social, emotional, behavioural and communication difficulties’’ group.ConclusionFour distinct profiles of developmental disorders were identified; gestational age was associated with two of these. Understanding which disorders children are most at risk of and how these co-occur can help provide accurate information to families and contribute to prompt diagnosis.
Gender-based violence and associated factors in communities in Uganda: data from the social innovation in health initiative
Authors: Awor Phyllis , Ahumuza Emmanuel , Namuggala Victoria Flavia , Nalwadda Christine 
Published: February 2025

BackgroundAddressing gender-based violence (GBV) requires a contextual understanding of its associated factors. The purpose of the study was to determine the prevalence and factors associated with GBV among beneficiaries of social innovation health projects in Uganda, inorder to inform the programmes.MethodsThis was a cross-sectional study with 500 participants from five social innovation projects addressing gender and health in Uganda. Modified Poisson regression analysis with robust standard errors was used for inferential statistics.ResultsLifetime prevalence of sexual violence was 23.3% among women and 2.9% among men. The prevalence of physical violence within the last 12 months was higher among women (23.7%), compared with men (7.7%). Women engaged in subsistence farming (prevalence ratio (PR)=1.12; 95% CI 1.01 to 1.24); (PR=1.19; 95% CI 1.06 to 1.33) and those from households where men alone made decisions about major household purchases (PR=1.18; 95% CI 1.05 to 1.33); (PR=1.19; 95% CI 1.05 to 1.34) were more likely to experience sexual violence and physical violence, respectively. Women having a disability (PR=1.20; 95% CI 1.03 to 1.39) were also more likely to experience physical violence.Conversely, women whose husbands were involved in domestic work were less likely to experience sexual violence (PR=0.84; 95% CI 0.78 to 0.90) and physical violence (PR=0.83; 95% CI 0.76 to 0.91).ConclusionThere was high prevalence of sexual and physical violence, among women in the studied population. There is a need to strengthen and scale up targeted interventions and policies to address the identified burden and risk factors and to promote gender equality, as is undertaken by the social innovation projects described in this study.
Liver transplant assessment for hepatocellular carcinoma: a single-centre experience
Authors: Faulkes Rosemary Elizabeth , Morris Sean , Bolimowska Oliwia , Rehman Zaira , Abbas Nadir , Dasari Bobby V M , Rajoriya Neil , Shah Tahir , Shetty Shishir 
Published: February 2025

ObjectiveThe incidence of hepatocellular carcinoma (HCC) continues to rise dramatically in the UK. Liver transplantation offers a potential cure and there is a large body of evidence demonstrating good outcomes. However, there is a paucity of data on the assessment, acceptance rates, and reasons for turning down liver transplantation in HCC.MethodsWe undertook an analysis of all patients with HCC referred for liver transplant assessment to a tertiary liver centre between January 2015 and January 2020. Patient and tumour demographics, assessment outcomes and overall survival were analysed. Multivariate analysis was performed on factors affecting listing decisions. To evaluate the impact of the COVID-19 pandemic, data collection was extended from March 2020 to March 2021.ResultsOf 263 patients with HCC who completed liver transplant assessment, 168 (64%) were accepted for listing. The most common factors associated with a decision not to list a patient were medical comorbidities (n=50, 56.2% of those not listed) and rapid tumour progression (n=25, 26.3%). Of patients who were listed, 145 (86.4%) received a liver transplant. Five year survival from the time of transplant assessment was 68% with transplant and 12% without.The pandemic resulted in more patients progressing out of criteria after listing. Prepandemic median dropout per annum was 2% (0%–9%), compared with 25% during the pandemic study period.ConclusionThis study provides outcomes on patients with HCC referred for transplant assessment, identifying factors for non-listing and confirming the negative impact of decreased transplant activity during the pandemic on waiting list dropouts for HCC patients.