bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dielectric Properties of PVA/MgO Polymer Nanocomposite Films
Authors: N SHRUTHI K , KUMAR MOHAN , V RAMARAJA VARMA , R SUSHMA , SANJEEV GANESH 
Published: March 2024

Abstract
The polymer nanocomposites (PNC) films using MgO and PVA were prepared by solution casting method. XRD, FTIR, and EDX investigations performed in combination gave detailed insights into the structural, chemical and elemental properties of the MgO-PVA composite along with the purity of the sample. The SEM images provide evidence for an even distribution of MgO nanoparticles in the prepared sample. The influence of MgO nanoparticle concentration on the ac conductivity and dielectric properties of nanocomposite films has been investigated. The values of both the real part (εʹ) and the imaginary part (εʹʹ) of the dielectric constant and ac-conductivity of PVA film have been observed to increase with increasing MgO concentration. At higher frequencies, the prepared PNC films exhibit a low dielectric value and behave as a lossless material. Thus, the findings of this study offer valuable insights that can be utilized for designing and assessing the performance of materials and devices across diverse fields, ultimately leading to advancements in electrical engineering and related disciplines.
Exploring Doping Prevalence in Sport from Indirect Estimation Models: A Systematic Review and Meta-Bibliometric Analysis
Authors: Sagoe Dominic , Cruyff Maarten , Chegeni Razieh , Veltmaat Annalena , Kiss Anna , Soós Sándor , de Hon Olivier , Heijden Peter van der , Petróczi Andrea 
Published: March 2024

Abstract
Background
To our knowledge, no previous systematic review and meta-analysis on doping prevalence in sport from Indirect Estimation Models (IEM) exists. We conducted a systematic review and meta-analysis complemented with a bibliometric analysis on empirical IEM-based studies of admitted doping prevalence in sport.
Methods
We conducted electronic database and ad hoc searches up to December 2023, estimated lifetime and past year prevalence rates, and conducted study quality/risk of bias as well as bibliometric analysis.
Results
Forty five studies were included in the review (meta-analysis: k = 33, bibliometric analysis: k = 22). The World Anti-Doping Agency’s definition of doping use was applied for data collection in most studies (k = 18) and doping prevalence was mostly assessed as past year/season (k = 20). Studies included in the meta-analysis were mostly conducted in Europe, particularly Germany (k = 10), and applied the Unrelated Question (k = 11) and Forced Response (k = 10) models. The lifetime prevalence rate of doping for competitive athletes was 22.5% (95% CI: 15.3–31.4, k = 10) and 17.2% (95% CI: 10.5–26.0, k = 4) for recreational sportspersons (t = -1.69, p = .100). Additionally, the past year prevalence rate of doping for competitive athletes was 14.3% (95% CI: 9.6–20.3, k = 14) and 10.3% (95% CI: 6.1–16.3, k = 7) for recreational sportspersons (t = -1.69, p = .100). Study participants were mostly multi-sport (k = 22) and competed at diverse levels. Additionally, majority of data (k = 27) were collected outside sport events. Most studies were evaluated as of moderate risk/quality (k = 17). Eight of the 17 journals where the prevalence estimation studies were published target sports readership. The mean normalized citation score is above the international average at 1.48 (range: 0.00–6.26), with two dominant but unconnected author communities.
Conclusions
One of six competitive athletes and recreational sportspersons in our sample of included studies admitted doping under IEM, exceeding the prevalence obtained via direct questioning and analytical testing. Despite their advantages, considerable internal variation in publication years and stable collaborations within the two identified communities of authors, IEM-based studies of doping prevalence require functional improvement.
Can a Mobile Application Improve Glucose-Related and Patient-Reported Outcome Measures (PROMS) in People with Type 1 Diabetes Mellitus? a Randomized Controlled Trial Using mySugr®APP
Authors: Cuixart Gemma , Corcoy Rosa , González Cintia 
Published: March 2024

Abstract

Purpose: Mobile applications (app) emerge as effective tools to empower people with type 1 diabetes mellitus (T1DM) and provide better self-care, quality of life (QOL) and glycemic control. The aim of the study is to test if mySugr®, an app for diabetes management, together with teleconsultations, can have a positive impact on these aspects and replace current clinical care.
Methods: Exploratory randomized clinical trial of 12 months of duration. People with T1DM were randomized to usual care (bolus calculator, 5 face-to-face visits) or intervention (mySugr® app, 3 face-to-face visits, 2 teleconsultations). Main outcome: Increase in empowerment, assessed with Diabetes Empowerment Scale Short Form questionnaire (DES-SF-S). Secondary outcomes: Change in additional glucose-related (blood glucose monitoring, mean blood glucose, standard deviation, coefficient of variation (CV), high and low blood glucose index) and patient-reported outcome measures (PROMs) (self-management, QOL and distress).
Results: 25 out of 28 participants completed the study (52% men, age44.52 years, diabetes duration 21.28 years). At 12 months, no significant differences were detected in the change of DES-SF-S and additional PROMs between arms. Similarly, no differences were detected in glucose-related outcomes except for the change in CV at 9 (control -1.87±4.98 vs intervention 5.89±11.33, p=0.008) and 12 months (control -2.33±3.54 vs intervention 5.12±11.32, p=0.018). Adherence and satisfaction with the app were high.
Conclusion: Patients with diabetes using mySugr® app and teleconsultation achieved similar results than those following usual care in empowerment, other PROMs and most glucose-related outcomes, supporting its use as an alternative.
The RCT was registered with ClinicalTrials.gov (NCT03819335, first registration 28/01/2019).
Molecular docking and DFT study of 4-difluoromethyl pyrazole derivatives as cyclooxygenase-2 inhibitor
Authors: Khan Muhammad Tahseen Nawaz , Hussain Riaz , Mubarik Adeel , Haider Muhammad Durair Sajjad , Ikram Muniba , Amin Ayesha , Nazar Muhammad Faizan , Hussain Ajaz , Ayub Khurshid 
Published: March 2024

Abstract
We applied molecular docking simulations and DFT to examine the binding interactions of 4-difluoromethyl pyrazole derivatives (3a-3h). We assessed the potential binding mechanisms and strengths of derivatives within the receptor's binding site. By methodical simulations, we elucidated the characteristics and interactions towards binding capacities. Proposed compounds were subjected to molecular docking with the major protease (PDB:3LN1) to assess binding affinities. In designed compounds (3a-3h), 3a and 3f show the highest docking score, leading to high affinity toward 3LN1. An energy score of -6.9765 Cal/mol of ligand 3g suggests a strong and advantageous binding affinity, with the negative number indicating stability. The reactivity parameters, FMO, and MEP of the drugs were estimated by DFT calculations. The strong affinity of 3a and 3f was attributed to the existence of three hydrogen bonds and several hydrophobic interactions between the drug and the essential amino acid residues of the receptor. Ultimately, the molecular docking findings were illustrated using the estimated molecule electrostatic potential data using DFT. All these characteristics showed varying degrees of influence on the binding affinity of these compounds with the active protein locations.
Breast cancer in Adolescent &amp; Young Adult (AYA) has a specific biology and poor patient outcome compared to older patients
Authors: Oshi Masanori , Yamada Akimitsu , Gandhi Shipra , Wu Rongrong , Sasamoto Mahato , Yamamoto Shinya , Narui Kazutaka , Ishikawa Takashi , Takabe Kazuaki , Endo Itaru 
Published: March 2024

Abstract
Background
We aimed to clarify the features of adolescents and young adults (AYA: younger than 40yo) breast cancer (BC) compared with other age groups in ER-positive/HER2-negative BC, given the effects of age-related hormonal status.
Methods
The cohorts analyzed were divided into: AYA (15-39yo), Perimenopausal (40-54yo), Menopausal (55-64yo), and Old (65 + yo). Clinicopathological and biological features were analyzed using gene set variation analysis and the xCell algorithm using transcriptome profiles from large public databases of ER-positive/HER2-negative BC (METABRIC; n = 1,353, SCAN-B; n = 2,381).
Results
Tumors were larger and more advanced among the AYA and Old age groups than among the other groups. Pathological lymph node positivity and Nottingham grade 3 were higher among AYA. AYA was significantly associated with triple-negative BC and higher HER2-positivity. AYA had poorer disease-specific and overall survival particularly compared to perimenopausal group. In the ER-positive/HER2-negative subtype, estrogen response late signaling decreased with age. AYA was associated with significantly higher BRCAness and DNA repair than the other groups. AYA significantly enriched cell proliferation-related and pro-cancerous gene sets (MTORC1, unfolded protein response, and PI3K/AKT/MTOR signaling) when compared to the others. Interestingly, these features have also been observed in small tumors. Infiltration of CD8+, regulatory, and helper type 2 T cells, and M1 macrophages was higher, while M2 macrophages were lower in AYA. Finally, ER-positive/HER2-negative BC in AYA patients has different features of gene mutations compared to other age groups.
Conclusions
ER-positive/HER2-negative BC in AYA was highly proliferative with high immune cell infiltration compared to other generations.
2-balanced sequences coding rectangle exchange transformation
Authors: Dvořáková Lubomíra , Masáková Zuzana , Pelantová Edita 
Published: March 2024

Abstract

We define a new class of ternary sequences that are 2-balanced. These sequencesare obtained by colouring of Sturmian sequences. We show that the class containssequences of any given letter frequencies. We provide an upper bound on factorand abelian complexity of these sequences. Using the interpretation by rectangleexchange transformation, we prove that for almost all triples of letter frequencies,the upper bound on factor and abelian complexity is reached. The bound onfactor complexity is given using a number-theoretical function which we computeexplicitly for a class of parameters.
MSC Classification: 68R15
Expression of PGC-1α, PPAR-α and UCP1 genes, metabolic and anthropometric factors in
response to sodium butyrate supplementation in patients with obesity: A triple-blind,
randomized placebo-controlled clinical trial
Authors: hosseini seyed ahmad , Amiri Parichehr , Saghafi-asl Maryam , Roshanravan Neda , Tootoonchian Mitra 
Published: March 2024

Abstract

Objective There is increasing evidence that gut metabolites have a role in the etiology of obesity. This study aimed to investigate the effects of sodium butyrate (NaB) supplementation on the expression of peroxisome proliferator activated-receptor (PPAR) gamma coactivator -1α (PGC- 1α), PPAR-α, and uncoupling protein 1 (UCP1) genes, as well as on metabolic parameters and anthropometric indices in persons with obesity.
Methods In this triple-blind placebo-controlled randomized clinical trial, 50 individuals with obesity were randomly assigned to NaB (600mg/day) + hypo-caloric diet or placebo group + hypo-caloric diet for 8 weeks. Serum levels of metabolic parameters, mRNA expression of PGC1-α, PPAR-α, and UCP1 genes in peripheral blood mononuclear cells (PBMCs), the participants' food intake and appetite sensations were assessed.
Results PGC1-α and UCP1 genes expression increased significantly in NaB group compared to the placebo at the endpoint. A significant decrease in weight, BMI, and waist circumference (WC) was also observed in NaB group. NaB significantly decreased fasting blood sugar (FBS) (P=0.04), low-density lipoprotein cholesterol (LDL-C) (P=0.038) and increased high-density lipoprotein cholesterol (HDL-C) (P=0.016). Food intake and appetite decreased significantly in NaB group (P<0.05).
Conclusions This investigation unveiled the substantial impact of NaB on some anthropometric and metabolic risk variables associated with obesity.
Influence of various intercropping systems on soil quality characteristics and their potential for climate change adaptation in Dedza, Malawi
Authors: Kammawmba Alice Zone , Vunain Ephraim , Mpeketula Placid , Meijboom Reinout 
Published: March 2024

Abstract

Malawi’s food security, mainly dependent on subsistence crop production by poor smallholder farmers, is seriously affected by the negative impacts of land degradation due to climate change and poor production practices. The effects of climate change and the increasing population also exacerbate the situation. As opportunities for land-extensive agricultural growth are reduced, modern production technologies such as intercropping have become essential for producing sufficient food for the country. The study aims to describe the effects of different cereal-to-legume intercropping systems on soil quality characteristics and crop yield for climate change adaptation in Dedza District, a case of Lobi Extension Planning Area (E.P.A.). Data on soil characteristics and crop yields were collected. The methodology involved soil sampling from 0–5 cm and 5–20 cm on the ridge, then 0–5 cm and 5–20 cm on the fallow from each plot, and later laboratory analyses for soil physical and chemical analyses. Results of one-way ANOVA showed that cereal-legume intercropping combinations in this study affected the soil chemical properties such as soil nitrogen, organic matter, particulate organic matter, and exchange capacity, which were higher in intercropping systems than monocropping (p < 0.05). However, the system did not affect the soil pH, K, P contents, soil moisture, and water infiltration characteristics (p > 0.05). Overall, the cereal and legume combination intercropping system had a significant and positive linear regression effect on crop yield (p < 0.001; R2 = 0.6325) with an average grain yield of about 357066.15 (kg/ha). These results indicate that the cereal and legume intercropping system positively influenced crop yield, encouraging smallholder farmers to consider cereal and legume crop combinations intercropping to improve soil chemical properties and boost crop productivity.
Diffuse Idiopathic Skeletal Hyperostosis (DISH): Palaeopathological Study on Human Remains from Parthian Cemetery, Liyarsangbon, Guilan, Iran; With a Special Reference to Metastatic Cancer as the Cause of Death
Authors: Eghdami Mohammad Reza , Roudbordeh Majid Gholamzadeh , Omami Mohammad Hassan Hedayati , Zaieni Habib , Bozorgnia Maryam 
Published: March 2024

Abstract

Diffuse Idiopathic Skeletal Hyperostosis (DISH) is a systemic noninflammatory condition that is characterized by unknown causes. It is closely associated with various factors including sex, age, environmental influences, genetic predisposition, and fluctuations in medication. Certain diseases, including gout, metabolic disorders such as type 2 diabetes as well as populations. Paleopathological studies of ancient remains indicate that it has been identified in various archaeological populations. The studied individual was discovered from Liyarsangbon cemetery, Amlash city, Guilan province, Iran. On the base of preliminary typology, the artifacts and grave types, the site was dated to the Parthian (247 BCE–224 CE) and in a few cases to the Sassanid period (224–651 CE). The remains of an individual with a potential case of DISH disease have attracted the interest of researchers. While there are other possible diagnoses such as spondyloarthropathies, Paget's disease, metabolic diseases, and POEMS syndrome. Following osteological examinations, advanced radiological imaging methods, in addition to visual inspection, were employed to differentiate between potential diagnoses. Based on criteria, the ultimate diagnosis was determined to be either DISH or eDISH. The presence of patchy sclerotic bone lesions in the majority of the pelvic, and spine, suggesting osteoblastic metastatic tumors that may have contributed to the individual's demise.
Differential Privacy based Cloud- Data Security Model (DP-DSM) with Deep Learning in Cloud
Authors: P Santhoshkumar S , H Lilly Beaulah 
Published: March 2024

Abstract

In particular, machine learning and data analytics applications are moving an increasing amount of data storage and computation from the local to the cloud due to the rapid development of cloud computing. However, because the cloud servers are managed by a third party, consumers cannot totally rely on them. As a result, it becomes difficult to implement privacy-preserving deep learning over cloud data from several data sources. The Differential Privacy based Cloud Security Model (DP-DSM), which secures both cloud data sets and the data sets of multiple providers, is thus proposed in this study as a novel paradigm. The model makes use of a differential privacy algorithm to protect the privacy requirements of various providers. Additionally, the model redesigns the training procedure and requires the data owner to include a randomization layer before transmitting the data in order to counteract an unreliable deep learning model. The Convolutional Neural Network (CNN) architecture is divided into three layers: the convolutional unit, the randomization unit, and the fully connected unit. In addition, the proposed approach is assessed for time consumption and attack detection accuracy, making it more useful for IoT-driven cloud environments than previous methods.
The Specific Shapes of Capillaries are Associated with Worse Prognosis in Patients with Invasive Breast Cancer
Authors: Swe Hnin-Wint-Wint , Fujisawa Masayoshi , Ohara Toshiaki , Komatsubara Yu , Yoshimura Teizo , Shien Tadahiko , Matsukawa Akihiro 
Published: March 2024

Abstract

Purpose
Angiogenesis is considered essential for tumor progression; however, whether histological counting of blood vessel numbers, expressed as microvessel density (MVD), can be a prognostic factor in breast cancer remains controversial. It has been suggested that the specific morphology of blood vessels such as glomeruloid microvascular proliferation (GMP) was associated with clinical parameters. Here, we aimed to clarify the significance of MVD with revised immunohistochemistry and to identify new blood vessel shapes that predict prognosis in breast cancer.
Methods
Four hundred and eleven primary breast cancer specimens were collected, and the sections were immunohistochemically stained with CD31 (single staining) and CD31 and Collagen IV (double staining). The prognosis of patients was examined according to MVD value, and the presence of GMP and other blood vessels with other specific shapes.
Results
With a sensitive and specific double immunostaining, high MVD value was associated even with better survival. The presence or absence of GMP was not related to patients’ prognosis. By contrast, patients with deep-curved capillaries surrounding tumor cell nests (C-shaped) or excessively branched capillaries near tumor cell nests showed a significantly poor prognosis. The presence of these capillaries was also correlated with clinicopathological parameters such as Ki-67 index and histological grade.
Conclusion
Even though MVD is widely used as a marker of angiogenesis, the complex morphology of blood vessels is significantly associated with clinical parameters. To estimate patients’ prognosis, the shape of blood vessels should also be taken into account.
Understanding the Dynamics of Digital Payment Adoption Among Public University Students of Bangladesh: A Quantitative Study
Authors: Apu Apu Chandra Das 
Published: March 2024

Abstract

Digital payment system has gained significant acceptability over the course of time across the world. Our daily life is being more dynamic than before due to the addition of these digital methods of payments. Bangladeshi universities are also mostly under the inclusion of digital payment system. In the current world, universities are adopting technological advancements for the modernization of their daily activities, including the adoption of digital payment systems. This study aims to investigate the utilization and effect of the digital payment system among the university students in various public universities in Bangladesh. By forming a structured questionnaire, primary data has been collected on the frequency of usage, reasons for adoption, perceived transparency compared to traditional methods of payments, impact on transaction speed, administrative burden minimization, major barriers to adoption, effect on financial management, ease of use, and potential for a shift to cashless campus.
Exploring the Diagnostic and Prognostic Predictive Values of Ferroptosis-related Markers in Lung Adenocarcinoma
Authors: Mao Guoliang , Xu Wuqin , Jamil Muhammad , Zhang Wei , Jiao Nanlin , Liu Yinhua 
Published: March 2024

Background:
Lung Adenocarcinoma (LUAD), a common and aggressive form of
lung cancer, poses significant treatment challenges due to its low survival rates.

Aim:
To better understand the role of ferroptosis driver genes in LUAD, this study aimed to
explore their diagnostic and prognostic significance, as well as their impact on treatment approaches
and tumor immune function in LUAD.

Methods:
To accomplish the defined goals, a comprehensive methodology incorporating both in
silico and wet lab experiments was employed. A comprehensive analysis was conducted on a
total of 233 ferroptosis driver genes obtained from the FerrDB database. Utilizing various TCGA
databases and the RT-qPCR technique, the expression profiles of 233 genes were examined.
Among them, TP53, KRAS, PTEN, and HRAS were identified as hub genes with significant
differential expression. Notably, TP53, KRAS, and HRAS exhibited substantial up-regulation,
while PTEN demonstrated significant down-regulation at both the mRNA and protein levels in
LUAD samples. The dysregulation of hub genes was further associated with poor overall survival
in LUAD patients. Additionally, targeted bisulfite-sequencing (bisulfite-seq) analysis revealed
aberrant promoter methylation patterns linked to the dysregulation of hub genes.

Result & Discussion:
Furthermore, hub genes were found to participate in diverse oncogenic
pathways, highlighting their involvement in LUAD tumorigenesis. By leveraging the diagnostic
and prognostic potential of ferroptosis driver hub genes (TP53, KRAS, PTEN, and HRAS), significant
advancements can be made in the understanding and management of LUAD pathogenesis.

Conclusion:
Therapeutic targeting of these genes using specific drugs holds great promise for
revolutionizing drug discovery and improving the overall survival of LUAD patients.