bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anti-aging effect of TRF2 inhibition in skeletal myofibers
Authors: Burbano Maria Sol Jacome , Robin Jérôme D , Martin Marjorie , Gondin Julien , Pousse Mélanie , Thomas Jean-Luc , Bauwens Serge , Girard Emmanuelle , Carmine Peggy Del , Belotti Edwige , Billard Pauline , Dorel Tiphaine , Schaeffer Laurent , Gilson Eric 
Published: April 2024

Abstract
Aged female mice lacking the Terf2 gene, encoding the telomeric protective factor TRF2, in their skeletal myofibers exhibit a younger muscle phenotype with lack of ongoing or past regeneration and myofiber atrophy, preserved muscle strength, and moderate prolonged lifespan. Since this is accompanied by a slight pro-oxidant effect without telomere deprotection, we propose that the age-related TRF2 downregulation triggers a mito-hormetic response with beneficial effect in the skeletal muscle.
Integrative analyses of DNA methylase expression and related immune landscape in Prostate Cancer
Authors: Zhang Jialong , Huang Cong , Wang Hongzhi 
Published: April 2024

Abstract
Objectives
DNA methylation is a common in epigenetics process which plays important roles in the initiation and progression of prostate cancer (PCa). However, the underlying mechanism remains poorly understood.
Methods and Results
In this study, we systematically analyzed expression level of DNA methylase in prostate cancer and their correlation with immune infiltration and patient outcomes. We enrolled the transcription data of 52 normal and 502 prostate cancer tissues for the study. First, we systematically analyzed data pertaining to patient clinical information and mRNA gene expression data. We found that 5 out of 8 key regulators of DNA methylase significantly increased in PCa. Subsequently, we identified two subgroups (clusters 1 and 2) via consensus clustering based on the expression of 8 DNA methylase. Cluster 2 had worse prognosis, higher histological grade and pathological stage compared with cluster 1. Moreover, cluster 2 was remarkably enriched for cancer-related pathways. We further constructed a robust risk signature based on the expression of DNA methylase. Further analysis indicated that this risk signature could be an independent prognostic factor for PCa. Moreover, the efficacy of this three-gene risk signature was validated in external dataset. We also show that the model is highly correlated with immune cell infiltration.
Conclusions
In summary, we in this study uncovered the vital roles of DNA methylase in PCa and developed a risk signature as a promising prognostic marker in PCa patients. At the same time, it provides a reliable basis for the choice of treatment.
A new minimal element theorem and generalized Ekeland’s variational principle in complete lattice optimization problem
Authors: Araya Yousuke , Du Wei-Shih 
Published: April 2024

Abstract

In this paper, we first introduce some types of set relations on the power set of n-dimensional Euclidean spaces which are proposed by Kuroiwa-Tanaka-Ha and Jahn-Ha. We also mension new types of cancellation laws of set relations. Second, we introduce a complete lattice-valued problem on the power set of n-dimensional Euclidean spaces proposed by Hamel et al. Applying nonlinear scalrizing technique in complete lattice, we present a new type of minimal element theorem and generalized Ekeland’s variational principle in complete lattice optimization problem.
AMS Subject Classification: 06B23, 06F30, 49J53, 58E17.
Sustainable urban planning to control flood exposure in the coastal zones of China
Authors: wu yijing , Li Jingwei , Wu Haoyuan , Duan Yongqiang , Shen Hanru , Du Shiqiang 
Published: April 2024

Abstract

Context.
Sustainable development in coastal zones faces escalating flood risk in the context of climate change and urbanization, and the rapid urban growth in flood zones has been one of the key drivers. Therefore, understanding the urban exposure to flooding (UEF) and its future scenarios is important in coastal zones.
Objectives.
The objectives of this study were: (1) to assess the future dynamics of UEFs in China's coastal zones, and (2) to identify a sustainable way of urban planning in controlling the growth of UEFs.
Methods.
Future UEFs in coastal China were assessed during 2020–2050 by combining urban expansion model, scenario analysis, and flood exposure assessment. Alternative scenarios were considered of shared socioeconomic pathways (SSPs), representative concentration pathways (RCPs), strategies of urban planning.
Results.
The results show that the 1000-year flood UEFs along coastal China was expected to grow under SSP2-RCP4.5 from 9,879 km2 in 2020 to 13424 (12997–13981) km2 in 2050, representing an increment of 35.88% (31.56–41.52%). Alternatively, the strategy of sustainable development planning could reduce the newly added UEF by 16.98% (15.63–18.67%) in a 1000-year flood scenario.
Conclusions.
The findings proved that the ways of urban growth matters in terms of affecting food exposure and risk and flood risk should be incorporated into urban planning for a sustainable landscape. The study could offer methodology and support for sustainable development strategies in reducing future urban flood risk.
The most severe case of multiple osteochondromas in paleopathological record is from an Early Medieval burial site in the Venetian Lagoon
Authors: Viva Serena , Lonoce Norma , Bigo Lorenzo , Cadamuro Silvia , Gelichi Sauro 
Published: April 2024

Abstract

In recent years, paleopathological cases from ancient contexts are being increasingly taken into account to reconstruct the clinical history of a number of diseases, in particular congenital ones, at times still featuring in the genes of present-day populations. The skeleton of a male (T97) with an estimated age-at-death of 40–45 years has been found in the Early Medieval phase of an archaeological site in the Venetian Lagoon (north-east Italy). Through the osteoarchaeological study, full skeletal CT, histopathological examination, and comparison with other case studies a diagnosis was made. It is now possible to provide a detailed evaluation of the most severe case of multiple osteochondromas (MO) ever to be documented by paleopathology. T97 currently appears to be the most severe case of MO ever to be attested from archaeological context. No skeletal remains documented so far, either in Italy or abroad, have revealed such a high number of osteochondromas and chondrosarcomas, i.e. malignant mutations. Moreover, the individual in question appears to have developed all the characteristic features of the pathology, resulting in a unicum in the international landscape. The present case of multiple osteochondroma is useful in understanding the natural clinical dynamics of this disease, providing for the first time a CT scan of a complete skeleton affected, as well as the survival of an individual with severe disabilities in a Medieval context.
Acupuncture for neuropathic pain in patients with dry eye disease: protocol for a systematic review and meta-analysis
Authors: Zhu Yan , Wang Shumin , Wei Juan , Zu Guangquan , Gao Qian , Wu Yunchuan , Wei Qingbo 
Published: April 2024

Abstract

Introduction Various randomized trials have demonstrated the therapeutic effect of acupuncture on the neuropathic pain (NP) in patients with dry eye disease (DED). However, the effectiveness and safety of acupuncture remain unclear. The objective of this systematic review is to assess the effectiveness and safety of acupuncture treatment related to NP in DED patients. Methods and analysis We will conduct searches across a range of databases including four English databases (PubMed, Cochrane Library, Embase, and Ovid), three Chinese databases (China National Knowledge Infrastructure, Wanfang, Chongqing VIP Information), three Japanese databases (Japan Agency for Science and Technology and Japan Medical Abstracts Service), as well as three Korean databases (Korean Medical Database, Oriental Medical Advanced Retrieval System, together with Research Information Service System) for papers published between January 2014 and October 2023. The search will not be restricted by language or publication date and focused solely on randomized controlled trials. Two researchers will independently perform data extraction, management, and analysis. Primary outcomes will consist of Schirmer's I test (SIT), tear breakup time (TBUT), ocular surface disease index scores (OSDI), neuropathic Pain Symptom Inventory modified for the Eye (NPSI-Eye), together with ocular pain assessment survey (OPAS). Secondary outcomes will consist of visual analogue scale (VAS) scores for ocular symptoms along with any acupuncture-related adverse events (AEs). Meta-analysis will be performed using Review Manager V.5.4. Meanwhile, the risk of bias will be independently evaluated utilizing the tool of "Risk of Bias" provided by Cochrane.Human Ethics and Consent to Participate declarations: not applicable.PROSPERO registration numberCRD42023487570.
Gender-Based Differences in Common Mental Disorders and Inequities in Access in Bangladesh
Authors: Saif Saiful Islam , Kushal Sayedul Ashraf , A Yahia Md , Azdi Zunayed Al 
Published: April 2024

Abstract

Bangladesh, the eighth-largest country in the world, has 162 million inhabitants. At the moment, 16.8% of individuals have mental health problems, which is roughly 6% more than the prevalence worldwide. However, globally, women are suffering mental health problems nearly twice as much as men but access mental health services less than men. This research aims to find gender-based differences in the prevalence of common mental health problems and inequity in mental health access in Bangladesh. In order to conduct this research, we used a desk review, which included both research and gray articles. Results depict that in patriarchal societies like Bangladesh, gender-based mental health inequity is pervasive, and women may be more susceptible to common mental health disorders, such as depression and anxiety. Contrary to this, this research has provided a broad overview of the gender-based inequity in mental health accessibility. We offered recommendations from our study and other literature and discussed how the results had ramifications.
Effect of Co 2+ substituted La 2 CuO 4 nanoparticles: Structural, morphological, optical and magnetic behaviour
Authors: Dash Chandra Sekhar , Yuvaraj S. , Jothiramalingam R. , Iqbal S. , Isaac R. S. Rimal , Bahajjaj Aboud A.A. , Sundararajan M. , Sukumar M. , Rajadurai L. 
Published: April 2024

Abstract

Impact of Co2+ doping on the properties of the structural, magnetic, functional and optical of La2CuO4 system formed by combustion process. Every sample of lanthanum cuprate was examined. The development of single-phase orthorhombic crystals with a Bmab space group was verified by X-ray diffraction patterns. The monophasic orthorhombic lattice structure of the material has crystallite size that falls between 28 and 41 nm. The lattice constant falls between a = 5.361 Å − 5.349 Å, b = 5.410 Å − 5.399 Å & c = 13.160 Å − 13.148 Å. The XRD of La2CuO4 perovskite nanomaterials correspond well with the calculated ones, with χ2 values closer to 1. Energy gap values decreases from 1.75 to 1.68 eV due to the quantum confinement. The hysteresis curves recorded at 300 K show that coercivity ranges from 210.09 to 177.37 Oe as the content decreases, confirming that the crystallite size increase. The samples were with soft ferromagnetic behavior found in the VSM study.
Ozil Phacoemulsification Handpiece versus Phacofragmatome in the Management of Dropped Lens Fragments: A Randomized Controlled Trial
Authors: Rana Vipin , Sinha DK , Dangi meenu , Bandopadhyay S , Kumar Ashok , Sharma Vijay Kumar , Tripathi Amit Nadan , Sharma Neeraj 
Published: April 2024

Abstract

Purpose
In cataract surgery, dislocation of lens fragments into the vitreous cavity is a rare but significant complication. This study compares the effectiveness of the Ozil phacoemulsification handpiece with the traditional phacofragmatome in managing posteriorly dislocated lens fragments to improve patient outcomes.
Methods
A prospective, randomized study was conducted at a tertiary care hospital in eastern India from January to June 2023, involving 40 patients divided into two groups using block randomisation. Group 1 underwent surgery with the phacofragmatome, while Group 2 used the Ozil handpiece. The primary objective was to evaluate the surgical duration and intraoperative complications, with secondary objectives assessing postoperative Best Corrected Visual Acuity (BCVA), incidence of Cystoid Macular Edema (CME), and safety of surgical sites.
Results
The use of the Ozil handpiece significantly reduced surgical duration (110 ± 2.54 seconds) compared to the phacofragmatome (152 ± 2.23 seconds, p < 0.001) and minimized the risk of lens fragments falling onto the retinal surface. No significant difference was found in postoperative BCVA or the incidence of CME between the two groups, indicating similar visual outcomes and safety profiles.
Conclusion
The Ozil phacoemulsification handpiece offers a more efficient and potentially safer alternative for managing posteriorly dislocated lens fragments in cataract surgery compared to the traditional phacofragmatome. These findings suggest the Ozil handpiece could improve surgical outcomes and patient safety.
Analysis of Ensembled Learning using Classical and Quantum Boosting Approaches for Diabetes Mellitus Prediction
Authors: Jha Sujeet Kumar , Adhikari Nanda Bikram 
Published: April 2024

Abstract
The paper focused on the implementation of Quantum machine learning and artificial intelligence techniques in diagnosing
diseases, specifically focusing on diabetes. The paper proposed
an ensemble approach that combined classical algorithms with
quantum processing unit (QPU)--based algorithms to improve
the performance of a model. The diabetes dataset used in the
study is obtained from the (Centre for Disease Control and Prevention (CDC) repository, and the goal is to
classify patients as either diabetic or non-diabetic. The ensemble
algorithms examined in the study include Voting classifier, Adaboost, Xgboost, Catboost, and QPU-based Qboost. While Qboost
demonstrates some quantum speedup, its performance is not
satisfactory. Therefore, the proposed hybrid model is developed
to enhance the performance metrics. The hybrid model achieves
an average accuracy, precision, recall, f1 score, and AUC score
of 0.89, 0.85, 0.95, 0.90, and 0.96, respectively, on the diabetes
dataset. In comparison, the top-performing Adaboost algorithm
achieves an average accuracy, precision, recall, f1 score, and AUC
score of 0.94, 0.91, 0.98, 0.94, and 0.98, respectively. The paper
concludes that while quantum computing (QC) significantly
improves computation speed, it comes at a slight cost of a 5
\% decrease in classification metrics and 0.186 in the AUC score.
Additionally, the study suggests that further development of Quantum computing
hardware will enhance overall performance metrics.
Validation of the ultra-brief self-report Patient Health Questionnaire-4 (PHQ-4) to measure anxiety and depression in Arabic-speaking adults
Authors: Obeid Sahar , Hemade Ali , Malaeb Diana , Sakr Fouad , Dabbous Mariam , Xu Jiale , Ying Yiwei , Jiang Chen , Meng Runtang , Fekih-Romdhane Feten , Hallit Souheil 
Published: April 2024

Abstract

Background: Anxiety and depression are psychiatric disorders that often coexist and share some features. Developing a simple and cost-effective tool to assess anxiety and depression in the Arabic-speaking population, predominantly residing in low- and middle-income nations where research can be arduous, would be immensely beneficial. The study aimed to translate the four-item composite Patient Health Questionnaire – 4 (PHQ-4) into Arabic and evaluate its psychometric properties, including internal reliability, sex invariance, composite reliability, and correlation with measures of psychological distress.
Methods: 587 Arabic-speaking adults were recruited between February and March 2023. An anonymous self-administered Google Forms link was distributed via social media networks. We utilized the FACTOR software to explore the factor structure of the Arabic PHQ-4.
Results: Confirmatory factor analysis (CFA) indicated that fit of the two-factor model of the PHQ-4 scores was modest (χ2/df= .13/1 = .13, RMSEA = .001, SRMR = .002, CFI = 1.005, TLI = 1.000). Internal reliability was excellent (McDonald’s omega = .86; Cronbach’s alpha = .86). Indices suggested that configural, metric, and scalar invariance were supported across sex. No significant difference was found between males and females in terms of the PHQ-4 total scores, PHQ-4 anxiety scores, and PHQ-4 depression scores. The total score of the PHQ-4 and its depression and anxiety scores were significantly and moderately-to-strongly associated with lower wellbeing and higher Depression Anxiety and Stress Scale (DASS) total and subscales scores.
Conclusion: The PHQ-4 proves to be a reliable, valid, and cost-effective tool for assessing symptoms related to depression and anxiety. To evaluate the practical effectiveness of the Arabic PHQ-4 and to further enhance the data on its construct validity, future studies should assess the measure in diverse contexts and among specific populations.
Solvability of a System of Nonlinear Integral Equations with a General Kernel
Authors: Dehghan Akram , Roshan Jamal Rezaei 
Published: April 2024

Abstract
This study establishes the adequate conditions for the solvability of a Volterra-type nonlinear system of integral equations with some general kernels. The proof of the existence result is established in the space C (I; B 1 B 2), where B 1 and B 2 represent two arbitrary Banach spaces. Darbo’s fixed point theorem and the methodologies for noncompactness measures are employed in our analysis. Moreover, we study the Cauchy problem for a system of fractional di¤erential equations. Finally, we present some examples in sequence spaces that demonstrate the application of our results to specific kernels and a class of more general kernels that satisfy a specific condition.
Mathematics Subject Classification: 47H08, 47G15, 47H10.
Research History, Current Trends, and Future Prospects of Liquid Biopsy in Triple-Negative Breast Cancer: An Analysis from a Global Perspective
Authors: Qu Yi , Wan Jixian , Li Ruihan , Li Xinyuan , Li Han , Li Yang , Huang Shengnan , Zhang Tingting , Yang Dawei , Chen Dongliang 
Published: April 2024

Abstract
Liquid biopsy has emerged as a significant technique in the field of triple-negative breast cancer, garnering widespread attention since 2012. Despite this, there remains a notable absence of bibliometric assessment in this area. This study screened 506 pieces of literature obtained from Web of Science (WoS) searches and selected 347 papers published between 2012 and 2024. Various software tools, including VOSviewer, CiteSpace, Bibliomatrix, and Scimago Graphica were used to visualize the results of the analyses. Through careful examination of visual graphs, this study conducted in-depth profiling mining, suggesting great potential and promise in this area. The linkage map of countries highlights the central roles played by the USA and China in this field over the past twelve years. Furthermore, the analysis of literature co-citations reveals a predominant focus on subtypes, cell models, and targeted therapies. Keyword analysis indicates previous emphasis on sensitive targets and advancements in the nano-field. Moreover, the evolution of keywords over time illustrates a transition from mechanistic inquiries to investigations spanning diagnosis, immunotherapy, and prognosis. These results offer valuable insights into the research process and potential future directions. Additionally, this paper integrates keywords, co-cited cores, coupling centrality, and visual analysis results of the most cited literature, using techniques such as timeline graph clustering and emergent words. Major hotspots are summarised, such as "biomarker", "target", "biological model", and "Immunotherapy inhibitors".
Neural Network-Driven Counter-Pulsation in Pulsatile Extracorporeal Membrane Oxygenator(ECMO): Enhancing Real-time Pulse Discrimination and Control Efficiency
Authors: Jang Hyun-Woo , Yoo Chang-Young , Kang Seong-Min , Choi Seong-Wook 
Published: April 2024

Abstract
Implementing counter-pulsation (CP) control in pulsatile extracorporeal membrane oxygenator (p-ECMO) systems offers a refined approach to mitigate risks commonly associated with conventional ECMOs. To attain CP between the p-ECMO and heart, accurate detection of heartbeats within blood pressure (BP) waveform data becomes imperative, especially in situations where measuring electrocardiograms (ECGs) are difficult or impractical. In this study, a cumulative algorithm incorporating filter-type neural networks was developed to distinguish heartbeats from other pulse signals generated by the p-ECMO, reflections, or motion artifacts in the BP data. A control system was implemented using the cumulative algorithm that detects the heart rate (HR) and maintains a proper interval between the p-ECMO's pulses and heart beats, thereby achieving CP. To ensure precise circulatory support control, the p-ECMO setup was connected to a mock circulation system, with the human BP waveforms being replicated using a heart model. The algorithm could maintain CP perfectly when the HR remained constant; however, owing to a 0.48-s delay from the HR detection to CP control, the success rate of the CP control decreases when a sudden increase in the HR occurred. In fact, when the HR varied by ± 5 bpm every minute, the CP success rate dropped to 78.62%, however this was still higher compared to the 25.75% success rate achieved when no control was applied.
Histopathological correlation of brain tumor recurrence vs radiation effect post-radiosurgery as detected by MRI Contrast Clearance Analysis: A validation study
Authors: Goulenko Victor , Madhugiri Venkatesh Shankar , Bregdy Amade , Recker Matthew , Lipinski Lindsay , Fabiano Andrew , Fenstermaker Robert , Plunkett Robert , Abad Ajay , Belal Ahmed , Alberico Ronald , Qiu Jingxin , Prasad Dheerendra 
Published: April 2024

Abstract

Purpose: The differentiation between adverse radiation effects (ARE) and tumor recurrence or progression (TRP) is a major decision-making point in the follow-up of patients with brain tumors. The advent of immunotherapy, targeted therapy and radiosurgery has made this distinction difficult to achieve in several clinical situations. Contrast clearance analysis (CCA) is a useful technique that can inform clinical decisions but has so far only been histologically validated in the context of high-grade gliomas.Methods This is a series of 7 patients, treated between 2018 and 2023, for various brain pathologies including brain metastasis, atypical meningioma, and high-grade glioma. MRI with contrast clearance analysis was used to inform clinical decisions and patients underwent surgical resection as indicated. The histopathology findings were compared with the CCA findings in all cases.Results All seven patients had been treated with gamma knife radiosurgery and were followed up with periodic MR imaging. All patients underwent CCA when the necessity to distinguish tumor recurrence from radiation necrosis arose, and subsequently underwent surgery as indicated. Concordance of CCA findings with histological findings was found in all cases (100%).Conclusions Based on prior studies on GBM and the surgical findings in our series, delayed contrast extravasation MRI findings correlate well with histopathology across a wide spectrum of brain tumor pathologies. CCA can provide a quick diagnosis and have a direct impact on patients’ treatment and outcomes.