bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantum Annealing-aided Design of an Ultrathin-Metamaterial Optical Diode
Authors: Kim Seongmin , Park Su-Jin , Moon Seunghyun , Zhang Qiushi , Kim Sun-Kyung , Luo Tengfei , Lee Eungkyu 
Published: March 2024

Abstract

Thin-film optical diodes are important elements for miniaturizing photonic systems. However, the design of optical diodes relies on empirical and heuristic approaches. This poses a significant challenge for identifying optimal structural models of optical diodes at given wavelengths. Here, we leveraged a quantum annealing-enhanced active learning scheme to automatically identify optimal designs of 130 nm-thick optical diodes. An optical diode is a stratified volume diffractive film discretized into rectangular pixels, where each pixel is assigned to either a metal or dielectric. The proposed scheme identifies the optimal material states of each pixel, maximizing the quality of optical isolation at given wavelengths. Consequently, we successfully identify optimal structures at three specific wavelengths (600, 800, and 1000 nm). In the best-case scenario, when the forward transmissivity is 85%, the backward transmissivity is 0.1%. Electromagnetic field profiles reveal that the designed diode strongly supports surface plasmons coupled across counterintuitive metal–dielectric pixel arrays. Thereby, it yields the transmission of first-order diffracted light with a high amplitude. In contrast, backward transmission has decoupled surface plasmons that redirect Poynting vectors back to the incident medium, resulting in near attenuation of its transmission. In addition, we experimentally verify the optical isolation function of the optical diode.
Interaction between type 2 diabetes and past COVID-19 on active tuberculosis
Authors: Calles-Cabanillas Liz E. , Aguillón-Durán Genesis P. , Ayala Doris , Caso José A. , Garza Miguel , Joya-Ayala Mateo , Cruz-Gonzalez America M. , Loera-Salazar Raul , Prieto-Martinez Ericka , Rodríguez-Herrera Javier E. , Garcia-Oropesa Esperanza M. , Thomas John M. , Lee Miryoung , Torrelles Jordi B. , Restrepo Blanca I. 
Published: March 2024

Abstract

BACKGROUND
The global setback in tuberculosis (TB) prevalence and mortality in the post-COVID-19 era have been partially attributed to pandemic-related disruptions in healthcare systems. The additional biological contribution of COVID-19 to TB is less clear. The goal of this study was to determine if there is an association between COVID-19 in the past 18 months and a new TB episode, and the role played by type 2 diabetes mellitus (DM) comorbidity in this relationship.
METHODS
A cross-sectional study was conducted among 112 new active TB patients and 373 non-TB controls, identified between June 2020 and November 2021 in communities along the Mexican border with Texas. Past COVID-19 was based on self-report or positive serology. Bivariable/multivariable analysis were used to evaluate the odds of new TB in hosts with past COVID-19 and/or DM status.
RESULTS
The odds of new TB were higher among past COVID-19 cases vs. controls, but only significant among DM patients (aOR 2.3). The odds of TB given DM was 2.7-fold among participants without past COVID-19 and increased to 7.9-fold among those with past COVID-19.
CONCLUSION
DM interacts with past COVID-19 synergistically to magnify the risk of TB. Latent TB screening and prophylactic treatment, if positive, is recommended in this COVID-19/DM/latent TB high-risk group.
A Framework for Game Theoretic Model for Cyber Treats Prevention
Authors: philip Adisa Solagbade , Olufisoye Akanbi Caleb , Kazeem Ogundoyin Ibrahim 
Published: March 2024

Abstract
The dynamic nature of cyber treatspresents formidable challenges in thwarting and managing cyberspace. Conventional security measures often lag-behind swiftly evolving tactics employed by cybercriminals, necessitating a more proactive approach. This paper introduces a framework that advocates for the integration of game theoretic models to introducestrategies for preventing cyber threats. The framework explores how attackers and defenders interact in the cyber using ideas from Non-Cooperative Non-Zero-Sum game theory and linear algebra was used to formulate the model. By comprehensively analyzing and modeling the decision-making processes of both parties, it becomes possible to implement proactive measures that fortify cybersecurity defenses. Two distinct performance metrics—residual energy and success rate—were used to assess the model's effectiveness. The results show that, under realistic assumptions, the model developed obtained an amazing success rate of 99.65%. This implies that a non-cooperative non-zero-sum approach can be put into place to improve the system's defence against cyber threats.
Identification of Therapeutic Potential of Triazole Antifungal Drugs in Psoriasis using Network Pharmacological Approach
Authors: Satpathy Rimpal , Sahu Nilanchala , Nagpal Dheeraj , Madan Swati , Ahmed Sarfaraz , Alam Perwez , Saxena Shikha 
Published: March 2024

Abstract

Psoriasis (PSO) is a chronic immune-mediated skin condition characterized by abnormal keratinocyte growth and inflammation. Clinical occurrences have hinted to a potential connection between fungi and psoriasis as several Malassezia species and Candida Albicans species have been linked to distinct psoriasis subtypes. Triazoles Antifungal drugs have been used mainly to treat Fungal diseases. In this study, we intend to find out different target mechanism pathway through which triazoles drugs can act in the pathophysiology of psoriasis by Network pharmacology approach. Utilizing Swiss Target Prediction, GeneCard, Pharmmapper, Venn diagram analysis, String database, and Cytoscape, the study identified 76 mutual targets out of 4492 for psoriasis and 294 for triazole derivatives. The PPI network highlighted core targets such as CASP3, CCL5, SRC, PPARG, STAT1, MMP9, EGFR, IL2, ESR1, and AKT1. KEGG pathway enrichment analysis unveiled relevant pathways, including proteoglycans in cancer and Th17 cell differentiation. The network pharmacology study and molecular docking method shows multi-target pathway mechanism of triazole antifungal drugs.
Clinical observation on 184 cases of transvaginal cervical cerclage
Authors: Zhou Min , Chen Huijun 
Published: March 2024

Abstract

Objective: To analyze the clinical characteristics and pregnancy outcomes of 184 pregnant women with cervical insufficiency (CI) who underwent transvaginal cervical cerclage (TVC) surgery, and to evaluate its effectiveness and clinical significance.
Method: A retrospective analysis was conducted on the case data of 184 pregnant women who underwent vaginal cervical cerclage from January 2017 to December 2023, including gestational age, gestational frequency, parity, cerclage time, cervical length before cerclage, extended gestational weeks after cerclage, pregnancy outcome, and newborn condition. Firstly, based on the cervical length at the time of cerclage, they were divided into a<2.0cm group (64 cases) and a ≥ 2.0cm group (83 cases); According to the timing of cervical cerclage surgery, 102 cases were divided into a scheduled group (including 44 cases of preventive cerclage and 58 cases of therapeutic cerclage) and an emergency group of 82 cases; The selective cervical cerclage group was divided into an early group (cervical cerclage performed at 9-16 weeks) of 44 cases and an advanced group (cervical cerclage performed at 16-24 weeks) of 45 cases based on the number of cycles of cerclage. The clinical characteristics of this disease were analyzed and summarized.
Result: The gestational age, extended gestational age, newborn body weight, and newborn Apgar score (1 and 5 minutes) of the group with cervical length ≥ 2.0cm during cerclage were significantly higher than those of the<2.0cm group, while the gestational age during cerclage was significantly lower than that of the<2.0cm group, with statistical significance (P<0.05 for all). There were statistically significant differences (P<0.05) in the cervical length during cerclage, gestational weeks during cerclage, extended gestational weeks, full-term delivery rate, newborn birth weight, 1-minute Apgar score, and 5-minute Apgar score between the prevention group and the emergency group of pregnant women. There was no statistically significant difference in the extended gestational week, delivery gestational week, delivery blood volume, newborn birth weight, fetal survival rate, cesarean section delivery rate, newborn 1-minute Apgar score, and newborn 5-minute Apgar score between the early group (12-16 weeks, 44 cases) and the late group (16-24 weeks, 55 cases).
Conclusion: Pregnant women with a cervical length of ≥ 2.0cm during cerclage have better pregnancy outcomes than those with a cervical length of<2.0cm; Preventive cervical cerclage can improve the rate of full-term delivery and fetal survival; Emergency cerclage is a feasible remedial measure; Transvaginal cervical cerclage at 16-25 weeks of pregnancy can be an effective method to prolong pregnancy time.
Quality of Data in Population-Based Cancer Registry and its Implications for Cancer Control: A Cross-Sectional Study in Northern Tanzania
Authors: Alloyce Julius Pius , Amour Maryam , Mushy Stella Emmanuel , Alloyce Raphael Pius , Sunguya Bruno 
Published: March 2024

Abstract
Background: Cancer remains a significant global health challenge, especially in low-resource settings where limited data obstructs effective control measures. Reliable cancer registries are essential tools for collecting, managing, and analyzing cancer-related data. In Tanzania, as in many other sub-Saharan African countries, the need for accurate and timely cancer data is critical for informed decision-making. This study assesses the data quality of a population-based cancer registry in Tanzania to improve cancer control efforts. Methodology: This study adopted a descriptive cross-sectional study design to analyze 9617 records of cancer patients in population-based cancer registry database (Canreg5) from 2018 to 2022. Data analysis is done using Stata 17.0 and IARC validity check software. The percentage of complete, valid, and timely records was computed and compared with the required target. Comparability analysis compared age-standardized rates (ASR) and percentages of morphologically verified (MV%) against the standards in sub-Saharan Africa.
Results: In the defined period from 2018 to 2022, a total of 9,617 records were included in the final analysis. The study found high data quality indicators: completeness at 94% for mandatory variables, validity at 76%, timeliness at 93%, and a high comparability with cancer data in sub-Saharan Africa at 60%. However, variations were noticed in age-standardized rates (ASR) and morphologically verified cases (MV). For comparability findings, mouth and pharynx cancer had lower age-standardized rates (ASR) for males (5.7) and females (3.4) but high morphological verification rates. Esophageal cancer had significantly higher ASR for males (22.0) and females (6.1), with moderate morphological verification rates. Stomach cancer had lower ASR but higher verification rates. Colon, rectum, and anus cancer had comparable ASR and higher verification rates.
Conclusion: The data quality in the population-based cancer registry at the study site was optimal, with a high proportion of completeness, timeliness, and comparability, but with suboptimal validity of data, particularly for date format, and unlike combinations that highlight continuous monitoring and quality checks. While data quality is vital, challenges like missing and invalid records persist, necessitating reinforced protocols and validation measures.
Mild-iodine-deficiency based on 24-hour urinary iodine excretion leads to significant metabolic changes in pregnant women at early stages of pregnancy
Authors: Fan Lijun , Bu Ye , Liu Zhiyong , Wang Sihan , Chen Shiqi , Zhang Wei , He Yan , Zhang Yashu , Sun Dianjun 
Published: March 2024

Abstract

The effects of mild iodine deficiency during the first and second trimesters on both pregnant women themselves and their offspring exhibited in consistent patterns. In this study, we aimed to address this issue by employing small molecule metabolomics. A total of 98 pregnant women in either the first or second trimester were recruited, with comprehensive data including basic information, 24-hour urine samples and blood samples collected, and subsequent evaluation of birth outcomes for their offspring. The 24-hour urinary iodine excretion (UIE) was detected and used as the dividing criterion to determine the iodine nutrition status of pregnant women. Serum metabolomics assay was performed by Ultra High Performance Liquid Chromatography Orbitrap Exploris Mass Spectrometry (UHPLC-OE-MS) platform. Differential metabolites as the potential iodine deficiency biomarkers were selected by multivariate statistical analysis methods. Association analysis was used to further analyze the relationship between the potential biomarkers and neonatal birth outcomes. As a result, there was no significant difference in maternal thyroid function indicators and neonatal outcomes between mild iodine deficiency and iodine adequate pregnant women. However, the metabolic profile of pregnant women with mild iodine deficiency was significantly disturbed compare to these with iodine adequate. A total of 28 different metabolites were screened, which could be used as the potential biomarkers of iodine deficiency. After adjusted age and pregnancy trimester, the expression of these biomarkers were also changed significantly. Furthermore, these markers were also related to fatty acid biosynthesis, tyrosine metabolism, tryptophan metabolism, arachidonic acid metabolism, and pentose and glucuronate interconversions. In addition, among these markers, 2-(4-Methyl-5-thiazolyl)ethyl octanoate was found to be associated with neonatal TSH, ACar(12:0), (9S,10E,12Z,15Z)-9-Hydroxy-10,12,15-octadecatrienoic acid showed a correlation with body length; whereas (9S,10E,12Z,15Z)-9-Hydroxy-10,12,15-octadecatrienoic acid was linked to body weight. In conclusion, mild iodine deficiency during the first and second trimesters dose not result in overt adverse effects on pregnant women and their offspring. However, at the metabolic level, mild iodine deficiency may disrupt the metabolic profile of pregnant women and impact the development of their offspring.
miRNA-7145-cuedc2 axis controls hematopoiesis through JAK1/STAT3 signaling pathway
Authors: Guo Chunming , Xu Yongsheng , Guo Rui , Huang Tao 
Published: March 2024

Abstract

Hematopoiesis ensures oxygen diffusion, tissue remodeling and immune protection in vertebrate. During embryogenesis, hemangioblasts are the source of all blood cells. Gata1a and pu.1 are co-existed in hemangioblasts when hemangioblasts are not differentiated into blood cells. However, the genes that determine the differentiation of hemangioblasts into myeloid or erythroid have not been fully uncovered. Here we showed that miRNA-7145, a previously unknown function miRNA, was enriched in erythrocytes at definitive wave, but not expressed in myeloid cells. Gain-of-function and loss-of-function analysis of miRNA-7145 revealed that miRNA-7145 functions as a strong inhibitor for myeloid progenitor cells differentiation while commitment for primitive erythropoiesis. Furthermore, we confirmed that cuedc2 is one of miRNA-7145 targeted-genes. Indeed, over-expression or knock-down of cuedc2 partially rescues the phenotype caused by miRNA-7145 gain-of-function or loss-of-function. Meanwhile, Gain-of-function and loss-of-function analysis of cuedc2 showed that cuedc2 is required for myelopoiesis while against to erythropoiesis. Finally, we found that over-expression of zebrafish cuedc2 in 293T cell inhibits JAK1/STAT3 signaling pathway. Collectively, our results uncover a previously unknown miRNA-7145-cuedc2 axis, which regulate hematopoiesis through inhibiting JAK1/STAT3 signaling pathway.
Intrinsically Disordered Regions Steer the Function Coordination of the Traveling Chromatin Modifier During Pol II Elongation
Authors: Li Bing , Pan Yixuan , Liu Meiyang , Ruan Chun , Peng Mengyuan , Hao Min , Zhang Qi , Xue Jingdong , Li Ningzhe , Guan Haipeng , Wang Pei , Hu Mingqian , Li Haitao , Wang Wenjuan , Song Juan , Yao Yanhua , Lao Yimin 
Published: March 2024

Abstract

The Rpd3S histone deacetylase complex suppresses cryptic initiation and maintains genomic integrity by deacetylating transcribed nucleosomes subsequent to RNA Pol II passage. Recent cryo-EM structure analysis of Rpd3S emphasized the significance of two asymmetrical Rco1/Eaf3 dimers in nucleosome binding. However, the mechanism by which Rpd3S interacts with nucleosomal substrates while traveling with elongating Pol II remains elusive. In this study, we elucidate the crucial role of the Rco1 N-terminal Intrinsically Disordered Region (IDR) in regulating Pol II association. Mutations within the K/R cluster of Rco1 IDR significantly impede Rpd3S binding to the C-terminal domain of Rpb1, the largest of subunits of Pol II (CTD), while leaving the overall complex integrity and nucleosome recognition unaffected. Moreover, we identify the Rco1-PHD1 and Eaf3-CHD domains as the minimal module responsible for specific interaction with Ser5-phosphorylated CTD. The Rco1 IDR functions by relieving autoinhibition from its C-terminal regions, thus enabling the binding of PHD1-CHD to CTD. Additionally, we uncover an evolutionarily conserved mechanism governing the distinct roles of the asymmetrical Rco1/Eaf3 dimers in coordinating nucleosome engagement and Pol II binding. These findings offer valuable new perspectives on the functional dynamics of mobile epigenetic modifying complexes that accompany processive machinery.
A study on the correlation between triple network connectivity and rumination of current episode major depressive disorder
Authors: Dong Xiao , Cheng Xiaoman , Qian Huichang , Liu Xiaozheng , Ma Jiehua , Liu Dandan , Liu Jian 
Published: March 2024

Abstract
Background
Rumination of Major Depressive Disorder(MDD) affects the occurrence and development of the disease.Although the triple networks abnormalities have been implicated consistently in MDD and rumination neuropathology, the correlation between MDD with current depressive episode as well as resting-state triple network alterations have not been clearly studied.
Methods
The present study analyzed Regions of Interest(ROI)-toROI connectivity across the default-mode network (DMN), the salience network (SN) as well as the frontal-parietal network (FPN), namely the Triple Network, of MDD patients with the current depressive episode(n = 19, 26 ± 5. 44 years old, 12 females and 7males) and healthy controls (HCs;n = 19, 25 ± 4. 18 years old, 14 females and 5males). FC values and the Rumination Response scale(RRS) scores were investigated by correlation analysis.
Results
Comparing with HCs, hyperconnectivity in MDD was appeared between the DMN and the SN. Pearson correlation analysis showed significantly positive and moderate relation between FC values and scores of RRS and its sub-scales.
Conclusions
Rumination in current episode MDD patients is related with FC between DMN and SN, which connects two large-scale functions networks involved numerous functions such as self-reference,attention and else. This study may provide new insights into the neural mechanisms of MDD and rumination and reflect biomarkers of MDD with current depressive episode.
Emotio-Intelligent: A New Adaptive Approach for Intelligent Evacuation in Crisis Situations.
Authors: Farhani Moncef , Kanzari Dalel 
Published: March 2024

Abstract
Addressing the critical challenge of evacuation, especially in crisis situations where uncontrollable emotions can significantly impact decision-making, is of paramount importance. In this article, the Emotional Intelligent Model is presented, a new approach that seamlessly integrates dynamic emotion recognition with an adapted intelligent evacuation strategy for crisis scenarios. Our methodology harnesses a combination of convolutional neural networks (CNN) for dynamic emotion sensing and long-term memory recurrent neural networks (LSTM) to provide decision support during evacuation. This paper provides an in-depth exploration of our system's architecture, encompassing the dynamic emotion recognition and personality profiling methods, as well as the adaptive evacuation strategy. During the experimental and validation phases, the MESA simulation platform was used. The results achieved confirm the effectiveness of the integrated emotional approach, which contributes to safer and smarter evacuation procedures in crisis situations.
Acoustical Properties of the New Sandwich Structures for Aircraft Cabin Interiors with Integrated Vacuum Insulation
Authors: Latsuzbaya V. , Middendorf P. , Völkle D. , Weber C. 
Published: March 2024

Abstract

The modern passenger aircrafts are required to meet high standards of comfort for passengers, whom spend a large amount of time in the cabin during the flight. The climate and noise inside the aircraft cabin are some of the important comfort parameters. In the search for new insulation materials, Vacuum Insulation Panels (VIP) were chosen due to their very low thermal conductivity. As part of the integration of the VIPs into the structure of the interior panels, it was found that the thermal conductivity of the total sandwich structure of the interior is 3–6 times less than the values of the conventional structures, thereby causing great interest in the usage of these materials for the aircraft cabin. This article focuses on studying the acoustic properties of the new structures with integrated vacuum insulation. As part of this analysis, sound transmission loss tests were carried out, which showed that the novel interior structures have promising acoustical properties.
Fine mapping and candidate gene analysis of Rf21(t) for the fertility restoration of Chinsurah Boro II-type cytoplasmic male sterile Oryza sativa (ssp. japonica) lines
Authors: Zhang Honggen , Xu Zuopeng , Wang Chen , Fan Liying , Li Meng , Huang Benxi , Du Yuanyue , Zhao Xiangqiang , Liu Qiaoquan , Tang Shuzhu 
Published: March 2024

Abstract
The combination of Chinsurah Boro II (BT)-type cytoplasmic male sterility (CMS) and Rf1, the main fertility restorer gene (Rf) for CMS-BT, has been extensively utilized for the production of three-line commercial japonica hybrid seeds. The identification of new Rf genes holds significance for the breeding BT-type restorer lines, aiming to enhance the heterosis level of BT-type japonica hybrids. In this present study, ‘02428’, a wide-compatibility japonica variety, was observed to partially restore fertility to BT-type CMS lines. Genetic analysis revealed that ‘02428’ carries a dominant Rf gene, Rf21(t), responsible for the fertility restoration of BT-type CMS lines. Leveraging BSA resequencing technology and molecular markers, the Rf21(t) locus was identified, and localized within a candidate interval of 6-12.5Mb on chromosome 2. Using the iso-cytoplasmic restorer populations, Rf21(t) was ultimately mapped to an interval of approximately 77 kb, encompassing 12 predicted genes, including LOC_Os02g17360, encoding a PPR domain-containing protein and LOC_Os02g17380 (Rf2), a cloned Rf for Lead rice-type CMS. Comparative sequence analysis, gene expression profiling, and gene knockout experiments confirmed LOC_Os02g17360 and LOC_Os02g17380 as the most likely candidates of Rf21(t). Furthermore, Rf21(t) showed the dosage effect on the fertility restoration of BT-type CMS lines. This newly identified Rf21(t) represents a valuable genetic resource for the breeding of BT-type japonica restorer lines. Our findings offer practical insights for breeders interested in advancing BT-type japonica hybrid development.