bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of foot reflexology on an infant with sensorineural hearing loss: A case report
Authors: Lee Yu-Jun , Chen Mao-Qing , Dong Jie 
Published: March 2024

BACKGROUND
Our study contributes to the further understanding of the mechanism of foot reflexology. Foot reflexology has been reported to affect hearing recovery, but no physiological evidence has been provided. This lack of evidence hampers the acceptance of the technique in clinical practice.
CASE SUMMARY
A girl was taken to North Sichuan Medical University Affiliated Hospital for a hearing screen by her parents. Her parents reported that her hearing level was the same as when she was born. The girl was diagnosed with sensorineural hearing loss (SNHL) by a doctor in the otolaryngology department. After we introduced the foot reflexology project, the parents agreed to participate in the experiment. After 6 months of foot reflexology treatment, the hearing threshold of the girl recovered to a normal level, below 30 dB.
CONCLUSION
Foot reflexology should be encouraged in clinical practice and for families of infants with SNHL.
3M syndrome patient with a novel mutation: A case report
Authors: Luo Ming-Ran , Dai Si-Ming , Li Yin , Wang Qian , Liu Hao , Gao Peng , Liu Jia-Yun , Chen Jian , Zhao Shu-Jie , Yin Guo-Yong 
Published: March 2024

BACKGROUND
A rare autosomal recessive genetic disorder, 3M syndrome, is characterized by severe intrauterine and postnatal growth retardation. Children with 3M syndrome typically exhibit short stature, facial deformities, long tubular bones, and high vertebral bodies but generally lack mental abnormalities or other organ damage. Pathogenic genes associated with 3M syndrome include CUL7 , OBSL1 and CCDC8 . The clinical and molecular characteristics of patient with 3M syndrome are unique and serve as important diagnostic indicators.
CASE SUMMARY
In this case, the patient displayed square shoulders, scoliosis, long slender tubular bones, and normal neurological development. Notably, the patient did not exhibit the typical dysmorphic facial features, relative macrocephaly, or growth retardation commonly observed in individuals with 3M syndrome. Whole exon sequencing revealed a novel heterozygous c.56681+1G>C (Splice-3) variant and a previously reported nonsense heterozygous c.3341G>A (p.Trp1114Ter) variant of OBSL1 . Therefore, it is important to note that the clinical features of 3M syndrome may not always be observable, and genetic confirmation is often required. Additionally, the identification of the c.5683+1G>C variant in OBSL1 is noteworthy because it has not been previously reported in public databases.
CONCLUSION
Our study identified a new variant (c.5683+1G>C) of OBSL1 that contributes to expanding the molecular profile of 3M syndrome.
High-grade pancreatic intraepithelial neoplasia diagnosed based on changes in magnetic resonance cholangiopancreatography findings: A case report
Authors: Furuya Nao , Yamaguchi Atsushi , Kato Naohiro , Sugata Syuhei , Hamada Takuro , Mizumoto Takeshi , Tamaru Yuzuru , Kusunoki Ryusaku , Kuwai Toshio , Kouno Hirotaka , Kuraoka Kazuya , Shibata Yoshiyuki , Tazuma Sho , Sudo Takeshi , Kohno Hiroshi , Oka Shiro 
Published: March 2024

BACKGROUND
High-grade pancreatic intraepithelial neoplasia (PanIN) exhibits no mass and is not detected by any examination modalities. However, it can be diagnosed by pancreatic juice cytology from indirect findings. Most previous cases were diagnosed based on findings of a focal stricture of the main pancreatic duct (MPD) and caudal MPD dilatation and subsequent pancreatic juice cytology using endoscopic retrograde cholangiopancreatography (ERCP). We experienced a case of high-grade PanIN with an unclear MPD over a 20-mm range, but without caudal MPD dilatation on magnetic resonance cholangiopancreatography (MRCP).
CASE SUMMARY
A 60-year-old female patient underwent computed tomography for a follow-up of uterine cancer post-excision, which revealed pancreatic cysts. MRCP revealed an unclear MPD of the pancreatic body at a 20-mm length without caudal MPD dilatation. Thus, course observation was performed. After 24 mo, MRCP revealed an increased caudal MPD caliber and a larger pancreatic cyst. We performed ERCP and detected atypical cells suspected of adenocarcinoma by serial pancreatic juice aspiration cytology examination. We performed a distal pancreatectomy and obtained a histopathological diagnosis of high-grade PanIN. Pancreatic parenchyma invasion was not observed, and curative resection was achieved.
CONCLUSION
High-grade Pan-IN may cause MPD narrowing in a long range without caudal MPD dilatation.
Ready for Digital B2B Sales or not? Wie die Digitalisierung die Vertriebsarbeit verändert
Authors: Fischer Heiko , Seidenstricker Sven 
Published: March 2024

ZusammenfassungDie digitale Transformation führt zu einem tiefgreifenden gesellschaftlichen Wandel und beeinflusst den Business-to-Business-Vertrieb (B2B-Vertrieb) erheblich. Der Vertriebsprozess ist zunehmend von digitalen Technologien geprägt und die Beziehung zwischen Kund*innen und Vertrieb verlagert sich in den digitalen Raum. Um den daraus resultierenden Herausforderungen im Vertrieb erfolgreich zu begegnen und den Vertrieb zu transformieren, ist die Readiness der Vertriebsmitarbeitenden sicherzustellen. Diese wird bei der Einführung digitaler Initiativen häufig vernachlässigt und die aktuelle Forschung erörtert die Readiness für den digitalen B2B-Vertrieb nur unzureichend. Der vorliegende Beitrag zeigt auf, was Readiness charakterisiert und untersucht die Anforderungen an den digitalen B2B-Vertrieb auf Mitarbeitendenebene. Durch qualitative Interviews werden drei wesentliche Sub-Dimensionen der Readiness für den digitalen B2B-Vertrieb abgeleitet: Kund*innenorientierung, hybrider Vertrieb und Marktorientierung. Vertriebsmitarbeitende benötigen ein tiefes Verständnis für Kund*innen, eine offene Haltung gegenüber digitalen Technologien und ein Bewusstsein für die Nutzung von Daten im Arbeitsalltag. Die Ergebnisse zeigen auf, dass es einer engeren Zusammenarbeit zwischen Marketing und Vertrieb bedarf, die digitale Transformation als kontinuierlicher Prozess zu verstehen ist und dass neue Disziplinen im Vertrieb erforderlich sind.
Towards a better understanding of anticipatory postural adjustments in people with Parkinson’s disease
Authors: Seuthe Jana , Heinzel Anna , Hulzinga Femke , Ginis Pieter , Zeuner Kirsten E. , Deuschl Günther , D’Cruz Nicholas , Nieuwboer Alice , Schlenstedt Christian 
Published: March 2024

Introduction
Previous studies have shown that anticipatory postural adjustments (APAs) are altered in people with Parkinson’s disease but its meaning for locomotion is less understood. This study aims to investigate the association between APAs and gait initiation, gait and freezing of gait and how a dynamic postural control challenging training may induce changes in these features.

Methods
Gait initiation was quantified using wearable sensors and subsequent straight walking was assessed via marker-based motion capture. Additionally, turning and FOG-related outcomes were measured with wearable sensors. Assessments were conducted one week before (Pre), one week after (Post) and 4 weeks after (Follow-up) completion of a training intervention (split-belt treadmill training or regular treadmill training), under single task and dual task (DT) conditions. Statistical analysis included a linear mixed model for training effects and correlation analysis between APAs and the other outcomes for Pre and Post-Pre delta.

Results
52 participants with Parkinson’s disease (22 freezers) were assessed. We found that APA size in the medio-lateral direction during DT was positively associated with gait speed (p<0.001) and stride length (p<0.001) under DT conditions at Pre. The training effect was largest for first step range of motion and was similar for both training modes. For the associations between changes after the training (pooled sample) medio-lateral APA size showed a significant positive correlation with first step range of motion (p = 0.033) only in the DT condition and for the non-freezers only.

Conclusions
The findings of this work revealed new insights into how APAs were not associated with first step characteristics and freezing and only baseline APAs during DT were related with DT gait characteristics. Training-induced changes in the size of APAs were related to training benefits in the first step ROM only in non-freezers. Based on the presented results increasing APA size through interventions might not be the ideal target for overall improvement of locomotion.
Transformativism and Expressivity in Hegel’s Philosophy of Mind
Authors: Peters Julia 
Published: March 2024

Abstract
According to a major trend in Hegel scholarship, Hegel advocates a McDowell-style transformativist conception of the human mind. Central to this conception is a methodological dualism, according to which phenomena belonging to the rational mind, in contrast to those belonging to non-rational nature, must be accounted for from within the ‘space of reasons.’ In this paper I argue, by contrast, that Hegel rejects methodological dualism. For Hegel, a constitutive aspect of the rational mind is the activity of expression. I show how Hegel’s philosophy of mind adequately accounts for low-level forms of expressivity without appealing to capacities connected to conceptual thought and judgment, and that he does so by drawing on methods similar to those employed within the empirical sciences of his time. Thus, for Hegel, the sphere of the rational mind is broader than the McDowellian space of reasons.
Infinite energy harmonic maps from quasi-compact Kähler surfaces
Authors: Daskalopoulos Georgios , Mese Chikako 
Published: March 2024

Abstract
We construct infinite energy harmonic maps from a quasi-compact Kähler surface with a Poincaré-type metric into an NPC space. This is the first step in the construction of pluriharmonic maps from quasiprojective varieties into symmetric spaces of non-compact type, Euclidean and hyperbolic buildings and Teichmüller space.
The effect of irradiance versus light dose on the antioxidant activity of two strains of Ulva lacinulata
Authors: Cardoso Isabel , Meiβner Anneke , Hofmann Laurie C. 
Published: March 2024

Abstract
The genus Ulva, described as a good source of antioxidants known for its antibacterial properties and associated with the capacity to adapt to different environments and high growth rates, has justified the increasing interest in its large-scale production. While extensive research has been done on optimizing the extraction of Ulva’s bioactive compounds, few studies were conducted on increasing or optimizing antioxidant activity (AA) of Ulva spp. during cultivation. Our study aimed to investigate an optimization method of Ulva lacinulata by testing the impact of light dose and irradiance on its AA. Two geographically different strains (NE-Atlantic and Mediterranean) were observed for 5 days under two irradiances (70 or 185 µmol photons m−2 s−1) with the same light dose (4 mol photons m−2 d−1). Samples were collected at different times (0, 3, 24, 48 and 120 h) to evaluate their antioxidant activity (with 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) radical decolorization assay) and photosynthetic performance (with Pulse Amplitude Modulated fluorometer). A strain-dependent response was observed in the NE-Atlantic strain which had significantly higher AA after 5 days (89 %) under the photosynthetic saturating irradiance, while the Mediterranean strain was not impacted, suggesting that light dose may significantly affect AA in certain Ulva spp.
Douglas fir bark: composition, extracts utilization and enzymatic treatment for enrichment of bioactive constituents
Authors: Sommerauer Lukas , Konkler Matthew , Presley Gerald , Schnabel Thomas , Petutschnigg Alexander , Hinterstoisser Barbara 
Published: March 2024

Abstract
Bark residues from Douglas fir are an abundant resource that is currently used primarily in low-value energy recovery or is landfilled. Bark extractives are rich in diverse compounds like terpenes, fatty acids, phenols, and sugars with potential uses in a variety of high value applications. The study explores the potential of enzymatic hydrolysis to improve phenolic compounds from Douglas fir bark. It also assesses differences in chemical composition among rhytidome, phloem, and comingled bark fractions from an industrial waste pile. Phloem fractions exhibit higher yields of extractives, rhytidome fractions have elevated lignin levels, while the comingled fraction lies between the two except in ash content which was higher than in the separated fractions. Fungal decay tests with Gloeophyllum trabeum and Coniophora puteana on extract treated wood suggest potential for growth inhibition in extracts, about 58–31 % and 30–7% mass loss (in average) respectively, but due to high mass loss at low concentrations an enzymatic modification approach seems crucial for enhanced inhibition. Growth responses in whole-cell fermentation approach display variability depending on the participating microorganisms. Enzymatic hydrolysis with beta-glucosidase improved the antioxidant properties of bark extracts and holds promise for altering the chemical composition and enhancing bioactivity.
Improving multilayer perceptron neural network using two enhanced moth-flame optimizers to forecast iron ore prices
Authors: Doush Iyad Abu , Ahmed Basem , Awadallah Mohammed A. , Al-Betar Mohammed Azmi , Alawad Noor Aldeen 
Published: March 2024

AbstractThe quality of the output produced by the multi-layer perceptron neural network depends on the careful selection of its weights and biases. The gradient descent technique is commonly used for choosing MLP’s optimal configuration, but it can suffer from being stuck in local optima and slow convergence toward promising regions in the search space. In this article, we propose two new optimization algorithms based on the moth-flame optimization algorithm (MFO), which mimics moths’ special navigation methods at night. We use these algorithms to enhance the performance of the training process of the MLP neural network. To demonstrate the effectiveness of our approach, we apply it to the problem of predicting iron ore prices, which plays an important role in the continuous development of the steel industry. We use a large number of features to predict the iron ore price, and we select a promising set of features using two feature reduction methods: Pearson’s correlation and a newly proposed categorized correlation. Surprisingly, new features not mentioned in the literature are discovered, and some are discarded. The time series dataset used has been extracted from several sources and pre-processed to fit the proposed model. We compare our two proposed MFO algorithms, the roulette wheel moth-flame optimization algorithm and the global best moth-flame optimization algorithm, against four swarm intelligence algorithms and five classical machine learning techniques when predicting the iron ore price. The results acquired indicate the superior performance of the suggested algorithms concerning prediction accuracy, root-mean-square error, mean-square error, average absolute relative deviation, and mean absolute error. Overall, our work presents a promising approach for improving the performance of MLP neural networks, and it demonstrates its effectiveness in the challenging problem of predicting iron ore prices.
Causal clauses as source of sentential complementation: cross-linguistic evidence and methodological issues
Authors: Hernáiz Rodrigo 
Published: March 2024

Abstract
In many languages, causal clause markers can also function as – or are formally identical to – complement markers (e.g., Bulgarian če, Twi se, or Latin quod). This isomorphism is often explained as the result of independent developments from a common source (interrogatives, relativizers, etc.). By contrast, it is also frequently accepted that in some cases the aforementioned identity originates in a type of structural change by which causal clauses are eventually reanalysed as factive complements. However, the nature of the proposed CAUSE > COMPLEMENT development, involving both semantic adjustments and syntactic integration, is not yet fully understood, and it remains unclear how recurrent this phenomenon might be from a cross-linguistic perspective. This article aims to shed light on these questions by analysing diachronic and cross-linguistic data and assessing some of the evidence given for the development of complementation from causal adverbial clauses. The observations reveal significant documentation gaps for postulated models of the emergence of complement clauses and highlight methodological issues that qualify previous explanations about the diachronic relationship between causal and complement clauses.
Decarbonizing our environment via the promotion of biomass methanation in developing nations: a waste management tool
Authors: Igwebuike Chidiebere Millicent , Oyegoke Toyese 
Published: March 2024

Abstract
For a long time, fossil fuel has been a part of our everyday lives and has constantly led to the emission of carbon dioxide (CO2) into the environment. The release of methane (CH4) into our surroundings can be caused by the decomposition of organic wastes produced by our daily activities; CH4 produced by human activity is responsible for at least 25 % of global warming. CH4 is a known potent greenhouse gas that can trap about 35 times more heat than CO2. These greenhouse gases play a role in climate change and global warming. It, therefore, becomes important to explore measures for decarbonizing our environment. Biomethane production using our generated waste is a promising decarbonization approach with significant potential for mitigating greenhouse gas emissions. This paper overviews potential biomass methanation feedstocks and investigates several technologies, such as anaerobic digestion, combined pyrolysis and methanation, and combined gasification and methanation. SWOT analysis of waste conversion to biomethane was conducted, and important points related to the scaling-up of biomethane production processes were outlined. Also, insights into prospects for promoting biomass methanation deployment were provided. In conclusion, biomass methanation has great potential for producing sustainable energy. Hence, collaboration between industrialists, researchers, government agencies, and stakeholders including an understanding of the financial investments, return on investments, or potential subsidies and incentives could enhance the practicality of the proposed solution. Research and development should be continuously carried out as they are necessary to scale up and promote the technology. Also, there should be technical training for stakeholders as it is essential for the smooth development of the sector.
Follow the LEAD
Authors: Cox Brendan 
Published: March 2024

If we are ever going to be successful at reducing the footprint of the criminal legal system response to people with unmet behavioral health issues, or those living in extreme poverty we need true up-stream solutions. Solutions that include allowing police, system actors and community members an approach that recognizes harm, addresses the needs of people in a humane way, and increases public safety. Law Enforcement Assisted Diversion/Let Everyone Advance with Dignity (LEAD) is that response.
Established in 2011 in Seattle in response to the failed War on Drugs, and its disparate impact on people of color, LEAD seeks to stop the ineffective and often harmful responses of the criminal legal system, while increasing public safety. Instead of continuing the cycle of arrest, LEAD diverts people out of the criminal legal system and into a long-term system of care coordination. A collaborative view of public safety, LEAD initiatives coordinate high level system players while engaging communities in ensuring better outcomes on an individual and community level.
LEAD has been established in jurisdictions across the United States and continues to expand. An evidence-based practice, LEAD has been evaluated in multiple sites and proven an effective response to public safety. LEAD provides the upstream response to system change that is needed in all communities.
Carvacrol prophylaxis improves clinical outcome and dampens apoptotic and pro-inflammatory immune responses upon Campylobacter jejuni infection of human microbiota-associated IL-10−/− mice
Authors: Heimesaat Markus M. , Langfeld Luis Q. , Schabbel Niklas , Mousavi Soraya , Bereswill Stefan 
Published: March 2024

AbstractIncidence rates of human Campylobacter jejuni infections are progressively increasing globally. Since the risk for the development of post-infectious autoimmune diseases correlates with the severity of the preceding enteritis and campylobacteriosis treatment usually involves symptomatic measures, it is desirable to apply antibiotic-independent compounds to treat or even prevent disease. Given its health-promoting including anti-inflammatory properties carvacrol constitutes a promising candidate. This prompted us to test the disease-alleviating including immune-modulatory effects of carvacrol prophylaxis in acute murine campylobacteriosis. Therefore, human gut microbiota-associated IL-10−/− mice were orally challenged with synthetic carvacrol starting a week before C. jejuni infection and followed up until day 6 post-infection. Whereas carvacrol prophylaxis did neither affect gastrointestinal pathogen loads, nor the human commensal gut microbiota composition, it improved the clinical outcome of mice, attenuated colonic epithelial cell apoptosis, and dampened pro-inflammatory immune responses not only in the intestinal tract but also in extra-intestinal organs including the liver and the spleen. In conclusion, our preclinical placebo-controlled intervention study provides convincing evidence that oral carvacrol pretreatment constitutes a promising option to mitigate acute campylobacteriosis and in turn, to reduce the risk for post-infectious complications.
The effect of ropivacaine infiltration on the expression of Vascular Endothelial Growth Factor (VEGF) on skin defect: experimental study on Wistar rats
Authors: Astranto Dyandri Yogi , Ghaib Husnul , Sahudi  
Published: March 2024

Link of Video Abstract: https://youtu.be/jNHUCHSk70Y

Background: The main problems of postoperative patients are pain and wound. The healing phases consist of hemostasis, inflammation, proliferation, and remodeling. Postoperative pain causes surgical stress, which disrupts wound healing by delaying the transition from the inflammatory phase to the proliferative phase. Ropivacaine infiltration is expected to reduce surgical stress. One of the parameters that can be used to assess wound healing is Vascular Endothelial Growth Factor (VEGF) expression. This study aims to evaluate the infiltration effect of ropivacaine on the expression of VEGF in post-surgical skin defects in Wistar rats.
Methods: This study was an experimental study using 32 Wistar rats (Rattus norvegicus), which were randomly divided into 2 groups. With a 2 cm full-thickness wound incision, the ropivacaine group was given 0.2% 1 ml of ropivacaine infiltration, while the control group was given NaCl infiltration. 0.9% 1 ml. Tissue samples were taken on day 5 to calculate VEGF expression through immunohistochemical examination. Data were analyzed using SPSS versin 23.0 for Windows.
Results: Assessment of the weight of the Wistar rats did not show a significant difference (p = 0.788). Using the IRS (Immunoreactivity Score), there was a significant difference in VEGF expression (p = 0.033) between the two groups. There were significant differences in the degree of VEGF cells between the two groups (p = 0.001). Analysis of the relationship between treatment and degree of VEGF cells showed a significant relationship (p = 0.005).
Conclusion: Infiltration of ropivacaine had effects on the expression of VEGF in postsurgical skin defects of Wistar rats