bluuebunny/crossref_metadata_2025_split huggingface dataset:
Observation of the nonanalytic behavior of optical phonons in monolayer hexagonal boron nitride
Authors: Li Jiade , Wang Li , Wang Yani , Tao Zhiyu , Zhong Weiliang , Su Zhibin , Xue Siwei , Miao Guangyao , Wang Weihua , Peng Hailin , Guo Jiandong , Zhu Xuetao 
Published: March 2024

AbstractPhonon splitting of the longitudinal and transverse optical modes (LO-TO splitting), a ubiquitous phenomenon in three-dimensional polar materials, will break down in two-dimensional (2D) polar systems. Theoretical predictions propose that the LO phonon in 2D polar monolayers becomes degenerate with the TO phonon, displaying a distinctive “V-shaped” nonanalytic behavior near the center of the Brillouin zone. However, the full experimental verification of these nonanalytic behaviors has been lacking. Here, using monolayer hexagonal boron nitride (h-BN) as a prototypical example, we report the comprehensive and direct experimental verification of the nonanalytic behavior of LO phonons by inelastic electron scattering spectroscopy. Interestingly, the slope of the LO phonon in our measurements is lower than the theoretically predicted value for a freestanding monolayer due to the screening of the Cu foil substrate. This enables the phonon polaritons in monolayer h-BN/Cu foil to exhibit ultra-slow group velocity (~5 × 10−6c, c is the speed of light) and ultra-high confinement (~ 4000 times smaller wavelength than that of light). These exotic behaviors of the optical phonons in h-BN presents promising prospects for future optoelectronic applications.
Structure-guided engineering of biased-agonism in the human niacin receptor via single amino acid substitution
Authors: Yadav Manish K. , Sarma Parishmita , Maharana Jagannath , Ganguly Manisankar , Mishra Sudha , Zaidi Nashrah , Dalal Annu , Singh Vinay , Saha Sayantan , Mahajan Gargi , Sharma Saloni , Chami Mohamed , Banerjee Ramanuj , Shukla Arun K. 
Published: March 2024

AbstractThe Hydroxycarboxylic acid receptor 2 (HCA2), also known as the niacin receptor or GPR109A, is a prototypical GPCR that plays a central role in the inhibition of lipolytic and atherogenic activities. Its activation also results in vasodilation that is linked to the side-effect of flushing associated with dyslipidemia drugs such as niacin. GPR109A continues to be a target for developing potential therapeutics in dyslipidemia with minimized flushing response. Here, we present cryo-EM structures of the GPR109A in complex with dyslipidemia drugs, niacin or acipimox, non-flushing agonists, MK6892 or GSK256073, and recently approved psoriasis drug, monomethyl fumarate (MMF). These structures elucidate the binding mechanism of agonists, molecular basis of receptor activation, and insights into biased signaling elicited by some of the agonists. The structural framework also allows us to engineer receptor mutants that exhibit G-protein signaling bias, and therefore, our study may help in structure-guided drug discovery efforts targeting this receptor.
An acetate electrolyte for enhanced pseudocapacitve capacity in aqueous ammonium ion batteries
Authors: Bao Zhuoheng , Lu Chengjie , Liu Qiang , Ye Fei , Li Weihuan , Zhou Yang , Pan Long , Duan Lunbo , Tang Hongjian , Wu Yuping , Hu Linfeng , Sun ZhengMing 
Published: March 2024

AbstractAmmonium ion batteries are promising for energy storage with the merits of low cost, inherent security, environmental friendliness, and excellent electrochemical properties. Unfortunately, the lack of anode materials restricts their development. Herein, we utilized density functional theory calculations to explore the V2CTx MXene as a promising anode with a low working potential. V2CTx MXene demonstrates pseudocapacitive behavior for ammonium ion storage, delivering a high specific capacity of 115.9 mAh g−1 at 1 A g−1 and excellent capacity retention of 100% after 5000 cycles at 5 A g−1. In-situ electrochemical quartz crystal microbalance measurement verifies a two-step electrochemical process of this unique pseudocapacitive storage behavior in the ammonium acetate electrolyte. Theoretical simulation reveals reversible electron transfer reactions with [NH4+(HAc)3]···O coordination bonds, resulting in a superior ammonium ion storage capacity. The generality of this acetate ion enhancement effect is also confirmed in the MoS2-based ammonium-ion battery system. These findings open a new door to realizing high capacity on ammonium ion storage through acetate ion enhancement, breaking the capacity limitations of both Faradaic and non-Faradaic energy storage.
Influence of electric double layer rigidity on CO adsorption and electroreduction rate
Authors: Hou Jiajie , Xu Bingjun , Lu Qi 
Published: March 2024

AbstractUnderstanding the structure of the electric double layer (EDL) is critical for designing efficient electrocatalytic processes. However, the interplay between reactant adsorbates and the concentrated ionic species within the EDL remains an aspect that has yet to be fully explored. In the present study, we employ electrochemical CO reduction on Cu as a model reaction to reveal the significant impact of EDL structure on CO adsorption. By altering the sequence of applying negative potential and elevating CO pressure, we discern two distinct EDL structures with varying cation density and CO coverage. Our findings demonstrate that the EDL comprising densely packed cations substantially hinders CO adsorption on the Cu as opposed to the EDL containing less compact cations. These two different EDL structures remained stable over the course of our experiments, despite their identical initial and final conditions, suggesting an insurmountable kinetic barrier present in between. Moreover, we show that the size and identity of cations play decisive roles in determining the properties of the EDL in CO electroreduction on Cu. This study presents a refined adaptation of the classical Gouy-Chapman-Stern model and highlights its catalytic importance, which bridges the mechanistic gap between the EDL structure and cathodic reactions.
The relationship between visual hallucinations, functioning, and suicidality over the course of illness: a 10-year follow-up study in first-episode psychosis
Authors: Kreis Isabel , Wold Kristin Fjelnseth , Åsbø Gina , Simonsen Carmen , Flaaten Camilla Bärthel , Engen Magnus Johan , Lyngstad Siv Hege , Widing Line Hustad , Ueland Torill , Melle Ingrid 
Published: March 2024

AbstractVisual hallucinations in psychosis are under-researched despite associations with increased illness severity, functional impairments, and suicidality in the few existing studies. Further, there are no long-term longitudinal studies, making it impossible to conclude if these associations are state or trait phenomena. In the current prospective longitudinal study, 184 individuals with first-episode psychosis were assessed with semi-structured clinical interviews and self-report questionnaires at baseline and 10-year follow-up. Participants were grouped based on lifetime experience of visual hallucinations: before or at baseline (VH+/+), first during follow-up (VH−/+), or never (VH−/−). Associations with functioning, suicide attempts, childhood trauma and other markers of illness severity were tested using multinomial logistic regression analysis. At baseline, the VH+/+ group (37.5%), but not VH−/+ (12.5%), had poorer functioning, higher symptom severity, a lower age at onset, and included more individuals with a history of multiple suicide attempts than the VH−/− group (50%). At follow-up, the VH−/+ group, but not VH+/+, had poorer functioning and higher symptom severity than the VH−/− group. However, the number of participants who committed multiple suicide attempts during the follow-up period was again significantly higher in the VH+/+ group. There was no association with childhood trauma. Hence, visual hallucinations are associated with impaired functioning and higher symptom severity, but only in the short-term. However, visual hallucinations that arise early in the course of illness are a risk indicator for repeated suicide attempts throughout the illness course. These findings highlight the relevance of assessing visual hallucinations and monitoring their development over time.
Black adolescents’ motivation to resist the false dichotomy between mathematics achievement and racial identity
Authors: Wilson Melody , Matthews Jamaal Sharif 
Published: March 2024

AbstractThis study investigates the racial-mathematical identity profiles of Black American adolescents. Survey data were collected in five schools across one U.S. urban school district at two time points (spring 2018 [n = 197] and spring 2019 [n = 210]). Based on extant research regarding psychological response patterns to racialized school stress, we investigated the existence of an identity negotiation pattern in which students were motivated to resist negative stereotypes about Black people by achieving well in mathematics. We conducted a latent profile analysis combining students’ self-beliefs across five indicators: racial centrality, racial public regard, mathematics attainment value, mathematics mastery experiences, and resistance motivation. Three distinct racial-mathematical identity profiles emerged: (1) Mathematics Devalued/Ambivalent, (2) Moderately Math Attained, and (3) Resistors. We found associations between profile membership and students’ gender, negative math emotions, and their receipt of cultural and critical mathematics instruction. We also found an association between the identity profiles and school type (academically selective “magnet” schools vs. open-enrollment neighborhood schools), but not in the direction that might be assumed. Moreover, we found that certain school environment factors (i.e., racial stereotyping and cultural and critical mathematics instruction) were significantly different in racially diverse magnet schools than in the neighborhood schools. Overall, our data reveal the existence of a highly motivated Resistor profile among Black students, that is predicted by cultural and critical mathematics instruction but underrepresented within this district’s selective magnet schools.
Sunset Yellow protects against oxidative damage and exhibits chemoprevention in chemically induced skin cancer model
Authors: Singh Saurabh , Yadav Sarika , Cavallo Celine , Mourya Durgesh , Singh Ishu , Kumar Vijay , Shukla Sachin , Shukla Pallavi , Chaudhary Romil , Maurya Gyan Prakash , Müller Ronja Lea Jennifer , Rohde Lilly , Mishra Aradhana , Wolkenhauer Olaf , Gupta Shailendra , Tripathi Anurag 
Published: March 2024

AbstractSkin cancer and other skin-related inflammatory pathologies are rising due to heightened exposure to environmental pollutants and carcinogens. In this context, natural products and repurposed compounds hold promise as novel therapeutic and preventive agents. Strengthening the skin’s antioxidant defense mechanisms is pivotal in neutralizing reactive oxygen species (ROS) and mitigating oxidative stress. Sunset Yellow (SY) exhibits immunomodulatory characteristics, evidenced by its capacity to partially inhibit the secretion of proinflammatory cytokines, regulate immune cell populations, and modulate the activation of lymphocytes. This study aimed to investigate the antioxidant and anti-genotoxic properties of SY using in-silico, in vitro, and physiochemical test systems, and to further explore its potential role in 7,12-dimethylbenz(a) anthracene (DMBA)/ 12-o-tetradecanoylphorbol-13-acetate (TPA)-induced two-stage skin carcinogenesis. In vitro experiments showed that pre-treatment of SY significantly enhanced the cell viability of HaCaT cells when exposed to tertiary-Butyl Hydrogen Peroxide (tBHP). This increase was accompanied by reduced ROS levels, restoration of mitochondrial membrane potential, and notable reduction in DNA damage in (SY + tBHP) treated cells. Mechanistic investigations using DPPH chemical antioxidant activity test and potentiometric titrations confirmed SY’s antioxidant properties, with a standard reduction potential ($${E}^{o}$$

E

o

) of 0.211 V. Remarkably, evaluating the effect of topical application of SY in DMBA/TPA-induced two-step skin carcinogenesis model revealed dose-dependent decreases in tumor latency, incidence, yield, and burden over 21-weeks. Furthermore, computational analysis and experimental validations identified GSK3β, KEAP1 and EGFR as putative molecular targets of SY. Collectively, our findings reveal that SY enhances cellular antioxidant defenses, exhibits anti-genotoxic effects, and functions as a promising chemopreventive agent.
Prospective cohort study evaluating the association between influenza vaccination and neurodegenerative diseases
Authors: Zhao Houyu , Zhou Xuan , Fu Kexin , Duan Yunxiao , Wen Qiaorui , Wang Shengfeng , Zhan Siyan 
Published: March 2024

AbstractThe effect of influenza vaccination (FluVac) on the risk of neurodegenerative diseases has not been well evaluated in prospective populations. We aimed to assess the association between FluVac and the risk of dementia and Parkinson’s disease (PD) in people aged 60 years or older through a prospective population-based cohort from the UK Biobank. A time-varying Cox regression model adjusted for baseline and repeatedly measured covariates was used to estimate the hazard ratio (HR) and 95% confidence interval (CI) of the association between influenza vaccination and risk of dementia/PD. We took into account 70,938 participants in the cohort, including 38,328 participants who got vaccinated. During a median follow-up period of 12.2 years, 2087 incident dementia cases occurred, including 281 cases who received FluVac and 1806 cases who were not vaccinated. In addition, 742 incident PD cases occurred, among whom 131 cases received FluVac and 611 PD cases did not receive FluVac. FluVac was associated with reduced dementia risk with an HR of 0.83 (95% CI, 0.72–0.95) but was not associated with PD incidence (HR = 1.07; 95% CI, 0.87–1.32) after controlling baseline and repeatedly measured covariates. Further, among all dementia cases, there were 733 Alzheimer’s disease (AD) (94 vaccinated cases and 639 non-vaccinated cases), 307 vascular dementia (VD) (34 vaccinated cases and 273 non-vaccinated cases), and 1047 cases with other dementias (OD) (153 vaccinated cases and 894 non-vaccinated cases). The HRs for the associations between FluVac and AD, VD, and OD were 0.79 (95% CI, 0.63–1.00), 0.58 (95% CI, 0.39–0.86), and 0.94 (95% CI, 0.78–1.14) respectively. A dose-response relationship was found in the association between FluVac and dementia but not in the association with PD. A major limitation of the study is the low accuracy in the diagnosis of dementia subtypes, namely AD, VD, and OD. However, Results of sensitivity analyses were consistent with the primary analyses. In conclusion, influenza vaccination is significantly associated with a reduced risk of incident dementia but not PD in community-dwelling adults in the UK Biobank population.
Cancer-Alterome: a literature-mined resource for regulatory events caused by genetic alterations in cancer
Authors: Yao Xinzhi , He Zhihan , Liu Yawen , Wang Yuxing , Ouyang Sizhuo , Xia Jingbo 
Published: March 2024

AbstractIt is vital to investigate the complex mechanisms underlying tumors to better understand cancer and develop effective treatments. Metabolic abnormalities and clinical phenotypes can serve as essential biomarkers for diagnosing this challenging disease. Additionally, genetic alterations provide profound insights into the fundamental aspects of cancer. This study introduces Cancer-Alterome, a literature-mined dataset that focuses on the regulatory events of an organism’s biological processes or clinical phenotypes caused by genetic alterations. By proposing and leveraging a text-mining pipeline, we identify 16,681 thousand of regulatory events records encompassing 21K genes, 157K genetic alterations and 154K downstream bio-concepts, extracted from 4,354K pan-cancer literature. The resulting dataset empowers a multifaceted investigation of cancer pathology, enabling the meticulous tracking of relevant literature support. Its potential applications extend to evidence-based medicine and precision medicine, yielding valuable insights for further advancements in cancer research.
Lumbar spine segmentation in MR images: a dataset and a public benchmark
Authors: van der Graaf Jasper W. , van Hooff Miranda L. , Buckens Constantinus F. M. , Rutten Matthieu , van Susante Job L. C. , Kroeze Robert Jan , de Kleuver Marinus , van Ginneken Bram , Lessmann Nikolas 
Published: March 2024

AbstractThis paper presents a large publicly available multi-center lumbar spine magnetic resonance imaging (MRI) dataset with reference segmentations of vertebrae, intervertebral discs (IVDs), and spinal canal. The dataset includes 447 sagittal T1 and T2 MRI series from 218 patients with a history of low back pain and was collected from four different hospitals. An iterative data annotation approach was used by training a segmentation algorithm on a small part of the dataset, enabling semi-automatic segmentation of the remaining images. The algorithm provided an initial segmentation, which was subsequently reviewed, manually corrected, and added to the training data. We provide reference performance values for this baseline algorithm and nnU-Net, which performed comparably. Performance values were computed on a sequestered set of 39 studies with 97 series, which were additionally used to set up a continuous segmentation challenge that allows for a fair comparison of different segmentation algorithms. This study may encourage wider collaboration in the field of spine segmentation and improve the diagnostic value of lumbar spine MRI.
Electromagnetic forming of AA1060 sheet based on mixed forces generated by a three-coil dual-power system
Authors: Li Yanxin , Tang Bo , Lv Yiliang , Xiong Qi , Zhao Xiang 
Published: March 2024

AbstractThe electromagnetic force used in electromagnetic forming is mainly divided into attraction and repulsion. Dual-coil attractive electromagnetic forming can be used in the field of sheet pit repair. However, the magnetic field and eddy current generated by the two coils compete with each other, and the energy utilization rate is low. Therefore, a compensation coil is introduced, and an electromagnetic forming scheme of a three-coil dual-power sheet based on mixed force is proposed and verified by simulation. It is found that the three-coil mixed force can effectively improve the competition between the magnetic field and eddy current. The loading of the mixing force is not a simple superposition of attraction and repulsion, but the mutual promotion of the two. The forming displacement of the three-coil mixed force forming scheme is 582% higher than that of the dual-coil attraction forming scheme, and 89% higher than that of the attract first and then repel forming scheme. The forming effect of the three-coil mixing force is related to the number of turns of the compensation coil. The research results can improve the energy utilization rate of electromagnetic forming and provide a new idea for the loading scheme of electromagnetic forming force field.
Assessing the impact of various tuberculin PPD brands on bovine tuberculosis diagnosis
Authors: Echeverría Gustavo , Zumárraga Martín J. , Proaño-Pérez Freddy , Blasco Francisco Barceló , de Waard Jacobus H. 
Published: March 2024

AbstractAlthough several brands of tuberculin purified protein derivatives (PPDs) are available for diagnosing bovine tuberculosis (bTB), comparative studies to determine their diagnostic accuracy are infrequent. In Ecuador we compared two different PPD brands for bTB diagnosis using skin testing and measuring skin thickness increase. Additionally, we evaluated four PPD brands, including those used for skin testing, in the Bovine Tuberculosis Interferon Gamma Test (IFN-γ test) measuring IFN-γ induction in whole blood. The study included 17 naturally tuberculosis-infected PPD and IFN-γ test positive bovines. Both the field and laboratory results showed significant differences in classifying the 17 bovines as bTB positive or negative. We hypothesize that several factors, such as the genetic background of the cows, sensitization to environmental mycobacteria, M. bovis strains involved in the bTB infection, and the manufacturing procedures of the PPDs, could have influenced the immune reaction toward the different tuberculin PPD brands. Our study emphasizes the necessity for comparative studies aimed at determining the diagnostic accuracy of PPD brands for bTB diagnosis as well as the development of standardized methods for PPD production and potency determination.
The comparative transient prediction on hydrodynamic characteristics and flow field properties of pump-jets with accelerating and decelerating ducts
Authors: Zhou Yunkai , Yuan Jianping , Cavazzini Giovanna , Fu Yanxia , Gao Quanlin 
Published: March 2024

AbstractPump-jet holds a pivotal position in various marine applications, underscoring the need for comprehending their transient behavior for the purpose of design enhancement and performance refinement. This paper employs Reynolds-averaged Navier–Stokes equations method in conjunction with Detached Eddy Simulation model. The study delves into the ramifications of accelerating and decelerating ducts, distinguished by camber f and attack angles α, on transient hydrodynamic characteristics. The hydrodynamic characteristics are investigated numerically, after the validation of the numerical methodology by comparing simulation outcomes against experimental results. Subsequently, the study delves into propulsion characteristics, followed by an exploration of time-domain and frequency-domain data transformed through fast Fourier transform to analyze thrust fluctuations and pulsating pressures. Additionally, a detailed examination of pressure distribution and velocity field is provided, aiming to dissect the mechanisms through the variations in f and α influence the flow field. Findings suggest that the outlet velocity of accelerating ducts significantly surpasses the inlet velocity, a behavior contrasted by decelerating ducts. Notably, the patterns of accelerating and decelerating ducts resulting from alterations in f exhibit consistent characteristics with those brought about by changes in α. However, several opposite characteristics surface in transient flow field due to the distinct modifications in the duct profile. Furthermore, by considering vorticity magnitude distribution and vortices, a comparative analysis elucidates the effects of varying f and α on rotor and stator trailing vortices. This contributes to understanding the flow instability mechanism under differing duct configurations. It is evident that changes in f and α exert significant influence on both performance and flow field.