bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predicting the Dominant Formation Mechanism of Multiplanetary Systems
Authors: Shariat Cheyanne , Hasegawa Yasuhiro , Hansen Bradley M. S. , Yu Tze Yeung Mathew , Hu Renyu 
Published: March 2024

Abstract
Most, if not all, Sun-like stars host one or more planets, making multiplanetary systems commonplace in our Galaxy. We utilize hundreds of multiplanet simulations to explore the origin of such systems, focusing on their orbital architecture. The first set of simulations assumes in situ assembly of planetary embryos, while the second explores planetary migration. After applying observational biases to the simulations, we compare them to 250+ observed multiplanetary systems, including 13 systems with planets in the habitable zone. For all of the systems, we calculate two of the so-called statistical measures: the mass concentration (S

c
) and orbital spacing (S

s
). After analytic and empirical analyses, we find that the measures are related to first order with a power law:

S
c

∼

S
s
β

. The in situ systems exhibit steeper power-law relations relative to the migration systems. We show that different formation scenarios cover different regions in the S

s
–S

c
diagram with some overlap. Furthermore, we discover that observed systems with S

s
< 30 are likely dominated by the migration scenario, while those with S

s
≥ 30 are likely dominated by the in situ scenario. We apply these criteria to determine that a majority (62%) of observed multiplanetary systems formed via migration, whereas most systems with currently observed habitable planets formed via in situ assembly. This work provides methods of leveraging the statistical measures (S

s
and S

c
) to disentangle the formation history of observed multiplanetary systems based on their present-day architectures.
Lightcurve Analysis of a Sample of Asteroids and Comets Observed with the Isaac Newton Telescope
Authors: Holst Isaac J. B. , Robinson James , Donaldson Abbie 
Published: March 2024

Abstract
We present an analysis of six asteroids and one comet using data from the Wide Field Camera on the Isaac Newton Telescope, La Palma. As part of this work we developed a pipeline to reduce and absolutely calibrate photometry of inactive small bodies. For three of the objects, there was sufficient data to measure their rotation periods. We report rotation periods of (2.7774 ± 0.0004) hr and (3.121 ± 0.003) hr for main belt asteroids (7891) Fuchie and 1999 CP29 respectively, neither of which to our knowledge currently have a well-constrained rotation period. We also measure a rotation period for Jupiter-family comet 169P/NEAT of (8.37 ± 0.04) hr which is consistent with previous works. Colours in various filter combinations (Sloan

r
′

,

g
′

,

i
′

and RGO Z) were also determined, and for the six observed asteroids we present an approximate taxonomic classification.
Noble Gas Planetology and the Xenon Clouds of Uranus
Authors: Zahnle Kevin 
Published: March 2024

Abstract
Noble gases provide tracers of cosmic provenance that are accessible to a future Uranus atmospheric probe. Argon and krypton are expected to be well mixed on Uranus with respect to H2 and He, although condensation at the winter pole may be possible. The Ar/H2 and Ar/Kr ratios address whether the materials accreted by Uranus resembled the extremely cold materials accreted by Jupiter’s atmosphere, whether they were warmer, like comet 67P/Churyumov–Gerasimenko (67P/C-G), or whether Uranus is like neither. Xenon condenses as an ice, probably on methane ice, in Uranus’s upper troposphere. Condensation may complicate the interpretation of Xe/H2, but it also presents an opportunity to collect concentrated xenon samples suitable for measuring isotopes. Solar system Xe tracks three distinct nucleosynthetic xenon reservoirs, one evident in the Sun and in chondritic meteorites, a second in refractory presolar grains, and a third evident in comet 67P/C-G and in Earth’s air. The first and third reservoirs appear to have been captured from different clouds of gas. The two gases do not appear to have been well mixed; moreover, the high 129Xe/132Xe ratio in 67P/C-G implies that the gas was captured before the initial nucleosynthetic complement of 129I (15.7 Myr half-life) had decayed. Xenon’s isotopic peculiarities, if seen in Uranus, could usefully upset our understanding of planetary origins. Krypton’s isotopic anomalies are more subtle and may prove hard to measure. There is a slight chance that neon and helium fractionations can be used to constrain how Uranus acquired its nebular envelope.
Nomenclatural revision of the syntaxa of European coastal dune vegetation
Authors: Marcenò Corrado , Danihelka Jiří , Dziuba Tetiana , Willner Wolfgang , Chytrý Milan 
Published: March 2024

This manuscript provides a review of the phytosociological nomenclature of the European syntaxa included in the classes Ammophiletea arundinaceae, Honckenyo peploidis-Elymetea arenarii, and Koelerio glaucae-Corynephoretea canescentis. The nomenclature has been refined and updated following the 4th edition of the International Code of Phytosociological Nomenclature (ICPN). In the Appendix, we submit two proposals (37, 38) to conserve the names Ammophilion arundinaceaeBraun-Blanquet 1933 and Medicagini marinae-Ammophiletum arundinaceaeBraun-Blanquet 1933.
Taxonomic reference: see references in the main text.
Syntaxonomic reference: see references in the main text.
Abbreviations: EVCC = European Vegetation Classification Committee; ICPN = 4th edition of the International Code of Phytosociological Nomenclature (Theurillat et al. 2021).
Comparison of Attainment and Protective Effects of Lupus Low Disease Activity State in Patients With Newly Diagnosed Versus Established Systemic Lupus Erythematosus
Authors: Golder Vera , Kandane-Rathnayake Rangi , Louthrenoo Worawit , Chen Yi-Hsing , Cho Jiacai , Lateef Aisha , Hamijoyo Laniyati , Luo Shue-Fen , Wu Yeong-Jian J. , Navarra Sandra V. , Zamora Leonid , Li Zhanguo , Sockalingam Sargunan , Katsumata Yasuhiro , Harigai Masayoshi , Hao Yanjie , Zhang Zhuoli , Basnayake B.M.D.B. , Chan Madelynn , Kikuchi Jun , Takeuchi Tsutomu , Bae Sang-Cheol , Oon Shereen , O’Neill Sean , Goldblatt Fiona , Ng Kristine Pek Ling , Law Annie , Tugnet Nicola , Kumar Sunil , Tee Cherica , Tee Michael , Ohkubo Naoaki , Tanaka Yoshiya , Lau Chak Sing , Nikpour Mandana , Hoi Alberta , Morand Eric F. 
Published: March 2024

ObjectiveTo assess whether Lupus Low Disease Activity State (LLDAS) attainment is associated with favorable outcomes in patients with recent onset systemic lupus erythematosus (SLE).MethodsData from a 13-country longitudinal SLE cohort were collected prospectively between 2013 and 2020. An inception cohort was defined based on disease duration < 1 year at enrollment. Patient characteristics between inception and noninception cohorts were compared. Survival analyses were performed to examine the association between LLDAS attainment and damage accrual and flare.ResultsOf the total 4106 patients, 680 (16.6%) were recruited within 1 year of SLE diagnosis (inception cohort). Compared to the noninception cohort, inception cohort patients were significantly younger, had higher disease activity, and used more glucocorticoids, but had less organ damage at enrollment. Significantly fewer inception cohort patients were in LLDAS at enrollment than the noninception cohort (29.6% vs 52.3%,P< 0.001), but three-quarters of both groups achieved LLDAS at least once during follow-up. Limiting analysis only to patients not in LLDAS at enrollment, inception cohort patients were 60% more likely to attain LLDAS (hazard ratio 1.37, 95% CI 1.16-1.61,P< 0.001) than noninception cohort patients and attained LLDAS significantly faster. LLDAS attainment was significantly protective against flare in both the inception and noninception cohorts. A total of 88 (13.6%) inception cohort patients accrued organ damage during a median 2.2 years of follow-up.ConclusionLLDAS attainment is protective from flare in recent onset SLE. Significant protection from damage accrual was not observed because of low rates of damage accrual in the first years after SLE diagnosis. (ClinicalTrials.gov:NCT03138941)
Morphological and molecular evidence of cryptic speciation in sympatric colour morphotypes of Mycale (Carmia) cecilia (Porifera: Poecilosclerida) from the Mexican Pacific
Authors: Castillo-Páez Ana , Llera-Herrera Raúl , Cruz-Barraza José Antonio 
Published: March 2024

Identifying cryptic species is pivotal for understanding marine biodiversity and optimizing strategies for its conservation. A robust understanding of poriferan diversity is a complex endeavour. It has also been extremely hampered by the high phenotypic plasticity and the limited number of diagnostic characters. Mycale (Carmia) cecilia has different body colours, even among individuals living together. We tested whether the colour variation could be due to polymorphism, phenotypic plasticity or cryptic speciation. Phylogenetic reconstructions of nuclear and mitochondrial loci were congruent. Individuals of different body colour did not cluster together and had high levels of genetic divergence. Furthermore, the green morphotype clustered in almost all reconstructions with Mycale (C.) phyllophila, as both showed higher gene similarity at the transcriptomic level (public transcriptome). Morphologically, the green individuals consistently showed discrepancies from the red ones. These results suggest that all individuals with the same body colour, either red or green, correspond to the same species, while individuals with different body colours probably belong to different species. These results reveal high levels of morphologic and genetic diversity, which could have important implications for what is known as M. (C.) cecilia and the Mycalidae systematics.
Livelihood status of the fishing community of Mahakanadarawa reservoir in Anuradhapura, Sri Lanka
Authors: Illangasingha C. K. , Wickramaratne I. U. , Rathnayaka R. M. S. M. , Dassanayake W. M. S. U. D. , Gamage M. G. K. N. 
Published: March 2024

Mahakanadarawa reservoir located in Anuradhapura is one of the major, perennial reservoirs in Sri Lanka, extending over 1,457 ha. It provides livelihood opportunities through fisheries, irrigation for agriculture, and fostering economic growth in the surrounding region. Yet the fisheries-based livelihoods of the Mahakanadarawa reservoir have not been fully assessed. Hence, this study investigated the fishery and fisher profile of the reservoir. Primary data were collected from eight landing sites. A pre-tested questionnaire was used to interview 72 fishermen using a mixed method. Main variables including social, human, physical, natural, and financial capitals, fishery profile, fish and fisheries-based post-harvesting techniques, market chain analysis, and fisheries management practices, catch per unit effort for the gillnet fishery were calculated. Secondary data including stocking fish fingerlings and species-wise harvesting data for the past 10 years were collected from the district aquaculture extension office (Anuradhapura) of the NAQDA. A secondary study on the length-weight relationship of Oreochromis niloticus along with its condition factor value was performed. It was revealed that O. niloticus had negative allometric fish growth (b = 2.6667) with a condition factor value of 1.9092. The female fish had a higher mean total length compared to the male fish. In the fishing community, 95.83% of males and 4.17% of females were engaged in fishery activities. Mainly gill nets and non-mechanized fiberglass canoes were used for fishing. The average CPUE was 0.000339 kgm-2day-1. A strong positive (r =0.841) correlation was reported for fish stocking and fish production. Fish smoking and sun drying were the common fish processing techniques. The fish supply chain targeted the regional market. A cooperative level co-management system was identified among the reservoir fishing community. The current study discloses the livelihood capitals of the fishing community along with the existing supply chain which can be utilized for the sustainable management strategy of the Mahakanadarawa reservoir in the long run.
Predictors of dissatisfaction with day care chemotherapy services among patients with cancer: A single center retrospective study
Authors: Seshachalam Arun , Rathnam Krishnakumar , Mahathi Konda , Senthil V. J. , Yathev Shakthi , Niraimathi K. 
Published: March 2024

ABSTRACT

Background:
Administration of chemotherapy in the day care is an integral part of medical oncology and involves a complex flow of diverse patients with varied needs.

Objective:
To analyze the factors predicting the overall patient dissatisfaction with the day care chemotherapy services.

Materials and Methods:
Two prospective audits were conducted to record the time and duration of all patient-related activities using structured questionnaires and a patient satisfaction survey, both of which were validated in-house. The audit forms were filled out by the psychologist and the satisfaction surveys were filled out by the patients or the parents in case of pediatric patients (below 18 years old). The audits were conducted between February 1, 2022 and February 20, 2022. Patient satisfaction was scored on a scale of 1 (very poor) to 5 (very good). A psychologist interviewed the key stakeholders daily to document the delays and the reasons for the delays in the Day Care Chemotherapy Unit. The waiting time and delays in chemotherapy preparation or delivery were considered non-value-added activities.

Results:
A total of 257 audit forms were collected. The male-to-female ratio was 1:4. The primary diagnosis was breast cancer in 121 (47%) patients. Seventeen patients (6.6%) had their chemotherapy sessions canceled, due to abnormalities in blood investigations and/or poor general condition. The mean system time for each patient was 5 h 40 min (Standard deviation [SD], 3 h 42 min). The mean oncologist waiting time was 30 min (SD, 17.4) and the bed allotment time was 1 h (SD, 1.04). The mean satisfaction score was 4.6 (SD, 0.3) out of 5. The satisfaction score was lowest for pharmacy services (mean, 3.96; SD, 0.67). Non-value-added activities constituted 41% of the overall system time. The patient-to-nurse ratio was 2.6:1, nurse-to-bed ratio was 1:1.4, and patient-to-bed ratio was 1.8:1. Dissatisfaction (score <5) was noted in all the pediatric patients. The place of residence, payment method, waiting time for the oncologist, and flow of patients was associated with patients’ complaints.

Conclusion:
Dedicated pediatric day care chemotherapy services and streamlining pharmacy services are required. Improving the appointment system of oncologists and increasing the bed strength will help improve patient satisfaction.
Recapitulating the tumor microenvironment in head-and-neck squamous cell carcinoma: A narrative review
Authors: Venkatkumar Shruthi , Narayan Madhu , Krishnan Rajkumar 
Published: March 2024

ABSTRACT
Interaction between the tumor microenvironment (TME) and tumor cells can promote disease progression. Understanding the biological make-up of head-and-neck squamous cell carcinoma (HNSCC) is of the utmost necessity. Innovative treatment modalities in recent times aimed at both the tumor cells and the constituents of the TME of the malignancy have resulted in improved patient outcomes. This review deals with the interaction of the TME with HNSCC. For this review, we searched in PubMed and Google Scholar and included articles relating to the TME published in English until September 2021. The pertinent data were extracted from the relevant articles and synthesized into a single review. This review provides a holistic view of the important players at the molecular level of the immune environment of the tumor in HNSCC and how they can be harnessed for targeted therapeutics for patients with head-and-neck cancers.
Nivolumab in platinum-refractory head-and-neck cancers: A retrospective observational audit from a tertiary cancer center
Authors: Patil Vijay M. , Muthuluri Hemanth , Choudhary Jatin , Parekh Deevyashali , Abraham George , Noronha Vanita , Menon Nandini , Dhumal Sachin , Prabhash Kumar 
Published: March 2024

ABSTRACT

Background:
Nivolumab and pembrolizumab are approved treatment options for platinum-refractory head-and-neck squamous cell cancer (HNSCC) based on the demonstration of improved outcomes in clinical trials. However, limited data exist on their efficacy in the real-world setting.

Objectives:
To determine the impact of immune checkpoint inhibitors in the treatment of platinum-refractory HNSCC and the associated outcomes in a real-world setting.

Materials and Methods:
This was a retrospective study conducted between August 1, 2016, and December 31, 2018 in the Department of Medical Oncology at the Tata Memorial Hospital, a tertiary cancer center in India. We included patients with advanced platinum refractory HNSCC who had been treated with nivolumab. Data regarding adverse events, response, overall survival (OS), and progression-free survival (PFS) were collected. Survival analysis was performed by the Kaplan–Meier method. Cox regression analysis was used to identify the factors which affected OS.

Results:
A total of 2796 patients qualified for potential treatment with immunotherapy, but only 41 (1.47%) were able to receive it. The dose used was 240 mg in seven patients (17.1%) and 3 mg/kg in the remaining 34 (82.9%). The response rate was 19.5% (n = 8). The median PFS and OS were 2.27 months [95% confidence interval (CI), 1.51–4.14] and 5.29 months [95% CI, 3.78–11.67], respectively. The 1 year OS was 33.6% (95% CI, 19.5–48.4). Oral cavity tumors were associated with a lower PFS (hazard ratio, 3.86; 95% CI, 1.67–8.92; P = 0.001) and OS (hazard ratio, 2.79; 95% CI, 1.26–6.17; P = 0.001).

Conclusion:
Nivolumab has a good impact on both OS and PFS even in the real-world setting of patients with extensively pretreated platinum-refractory HNSCC similar to what has been reported in the pivotal studies. Among the patients who are treated with nivolumab, those with oral cavity tumors have a worse OS and PFS relative to those of other sites. This hypothesis-generating observation requires further investigation.
A narrative review of the role of common EGFR mutations in pathogenesis and treatment of non-small-cell lung carcinoma
Authors: Sharma Mansi , Basu Dharmishtha A. , Nathany Shrinidhi , Amrith B. P. , Batra Ullas 
Published: March 2024

ABSTRACT
Epidermal growth factor receptor (EGFR) mutant non-small-cell lung cancer (NSCLC) is an important subtype of lung cancer. With the existing and ongoing research and multiple targeted therapeutic options available, the treatment landscape of this subset is rapidly evolving. This is the first review article in the series on EGFR-mutant NSCLC in which we describe the structure of EGFR, the molecular biology of common EGFR mutations, diagnostic modalities, and various treatment options for all stages of NSCLC harboring common EGFR mutations. We searched for the articles in various databases including OncoKB, NCBI: PubMed, Embase, Scopus, and MyCancerGenome, using the keywords “EGFR”, “NSCLC”, “Osimertinib”, and “Gefitinib”. To compile this review, a total of 132 articles were utilized.
Identifying the Challenges of Hospital Management in the Conditions of the Coronavirus Disease-2019 Pandemic: A Systematic Review
Authors: Ghazanchaei Elham , Varahram Mohammad , Roozbahani Rahim , Dizaji Mehdi Kazempour 
Published: March 2024

Abstract
Hospitals, as health providers, will quickly encounter an increased demand for health services during infectious crises. The present systematic study investigates hospital management-related challenges during the coronavirus disease-2019 infectious crisis. The search was conducted systematically across four databases, including PubMed, Scopus, Ovid, Science Direct, CINAHL, Clinical Key, and EMBASE databases. The relevant articles published from 2019 to 2023 were collected. Search terms used were according to medical subject headings terminology. For searching the databases, the PICOS format 26 and 27 was used, wherein P represents population,” I” represents intervention, “C” represents comparator, “O” represents outcomes, and “S “ represents study design. We specifically reviewed studies eligible according to the inclusion and exclusion criteria. A total of 880 articles were identified from the reviewed databases. A total of 10 duplicates were identified and removed with the help of web-based reference management software (EndNote). For a systematic review, after screening the title and abstract, 772 texts were excluded from the research, and 98 texts were reviewed for the full review of the article. After the full study of the article, 66 texts were excluded from the study, and finally, 32 texts were fully evaluated. Formulating plans for making medical centers prepared to provide services to patients under emergency and pandemic conditions is an important step in hospital management in crises.
Educational Interventions Planned to Increase Human Papillomavirus Vaccination Acceptance among Adolescents and Their Parents in Asia: A Systematic Literature Review
Authors: Ramezankhani Ali , Bahrambeygi Fatemeh 
Published: March 2024

Abstract
One of the Global strategies to accelerate the elimination of cervical cancer is vaccinated with HPV vaccines by age 15 years by 2030. Recent studies showed that increased vaccine-related knowledge associated with HPV-vaccine acceptance and intention to vaccinate. In other words, insufficient information is the main barriers to vaccination acceptance. Accordingly, interventions that improve understanding of HPV vaccines may increase HPV vaccination coverage. The aim of this study was to summarize educational interventions designed to increase HPV vaccine acceptance in adolescents and their parents. We searched the databases of PubMed, Science Direct and Google Scholar on October-December 2020. We performed a literature search for published articles in English and searched relevant keywords (papillomavirus vaccines and knowledge, acceptance, intervention studies, communication, education). Our search was limited to studies targeting populations from Asian countries. Thirteen interventional studies performed in Asian countries met the inclusion criteria. Five studies used PowerPoint presentation and slide presentation as an educational intervention. Two studies applied written media that was an educational sheet that provided information on HPV vaccines. Two studies used social media and mobile for educational intervention. Two studies designed the educational intervention in 30 minutes and 1 hour lecture which following by question and answer. Two of studies conducted two educational interventions. First one was applied PowerPoint presentation and social media and the second one used lecture and group discussion. HPV vaccine acceptance is varied widely between studies across Asian countries. Increasing public awareness about HPV vaccines, will increase acceptance. Increasing acceptance, will lead to demand people for health policy makers to will introduce HPV vaccines into their national immunization program.