bluuebunny/crossref_metadata_2025_split huggingface dataset:
SHOULD I STAY OR SHOULD I GO–A rapid qualitative study of principal deteriorating factors experienced by nurses relating to their intentions to leave their current position in a medical hospital department
Authors: Berthelsen Connie , Hansen Carrinna Aviaja 
Published: March 2024

AbstractBackgroundHigh nurse turnover in hospitals is a worldwide problem with dire consequences for patient care such as increased mortality and a decrease in patient safety. A specific effort to retain nurses is urgently needed due to the many vacant nursing positions, especially across the Medical hospital departments.AimTo identify the principal deteriorating factors experienced by nurses relating to their intentions to leave the medical department at a university hospital.MethodsA rapid qualitative research methodology was used. Participants comprised 22 registered nurses employed in five university hospital medical department units. The Rigorous and Accelerated Data Reduction (RADaR) technique was therefore used for data collection through qualitative semi‐structured interviews and analysis. COREQ was used for reporting the study.ResultsThe RADaR analysis detected a downward spiral of five principal deteriorating factors influencing nurses' intentions to leave their position in the medical department. The factors were resignations from several nursing colleagues combined with too few and inexperienced nurses present during shifts, additional tasks assigned, a management refraining from improving the problematic issues, leading to decisive consequences for patient care and a declining feeling of professional care.ConclusionsThe lack of nurses in the department caused missed nursing care, which affected the nurses' job satisfaction and intentions to leave their positions. Future research initiatives must focus on evaluating successful interventions to maintain the nurses in the positions. Further knowledge, is also needed, to investigate how we can change the downward spiral to a story of retention success.
The efficacy and safety of neubotulinumtoxinA for the treatment of forehead horizontal lines in Asians – A clinical, prospective, interventional, split‐face study
Authors: Sy Jessica Jane , Wu Raymond , Wan Jovian , Kim Soo‐Bin , Yi Kyu‐Ho 
Published: March 2024

AbstractBackground:Botulinum toxin injections are widely sought after in the field of medical aesthetics, offering consumers a variety of brand choices. Two commonly available botulinum toxin products, onabotulinumtoxinA and neubotulinumtoxinA, are featured in numerous clinics, leading many to question whether there are discernible differences in results, given their varying price ranges.ObjectiveTo evaluate the efficacy and safety of neubotulinumtoxinA for the treatment of forehead horizontal lines.MethodsA 12‐week prospective, single‐centre, interventional split‐face study was conducted, including 30 subjects. These enrolled subjects received a single treatment session, with neubotulinumtoxinA applied to the left side of the forehead and onabotulinumtoxinA to the right side. A superficial injection was performed in all individuals, where the product was injected subdermally in the frontalis muscle. Evaluation was conducted at baseline, 7 days, 14, days and 4, 8, and 12 weeks after treatment, both when the eyebrows were at maximum lift and in a resting position. Treatment efficacy was assessed by two physicians and self‐assessed by the patients, using the Fitzpatrick Wrinkle Classification system. Adverse events were documented to evaluate safety.ResultsThe study found no statistically significant difference in the efficacy of neubotulinum and onabotulinum for treating forehead wrinkles, as indicated by p‐values above 0.05 for both static and dynamic conditions. No safety and adverse events were observed in both formulations.ConclusionThis study has demonstrated that neither formulation is inferior to each other in the treatment of forehead horizontal lines.
Movement in disguise: Morphology as a diagnostic for verb movement in Algonquian
Authors: Bogomolets Ksenia , Fenger Paula , Stegovec Adrian 
Published: March 2024

AbstractThis paper argues for a unification of two seemingly unrelated phenomena from unrelated language families: Verb Second in Germanic, and Conjunct versus Independent Order in Algonquian. It is argued that both reflect the possibility of the verb moving to C. While in Germanic this results in word order differences, in Algonquian V‐to‐C movement is detectable only via morphological alternations in agreement morphology. Under this view, Conjunct/Independent agreement and V2 are merely distinct reflexes of the same underlying process. This opens up new avenues of research in relation to V‐to‐C movement, framing it as a parametric option with potentially very different surface results in different languages depending on the setting of other parameters.
Whole‐genome sequencing of allotetraploid bermudagrass reveals the origin of Cynodon and candidate genes for salt tolerance
Authors: Wang Huan , Fang Tilin , Li Xiaoning , Xie Yan , Wang Wei , Hu Tao , Kudrna David , Amombo Erick , Yin Yanling , Fan Shugao , Gong Zhiyun , Huang Yicheng , Xia Chunjiao , Zhang Jianwei , Wu Yanqi , Fu Jinmin 
Published: March 2024

SUMMARYBermudagrass (Cynodon dactylon) is a globally distributed, extensively used warm‐season turf and forage grass with high tolerance to salinity and drought stress in alkaline environments. However, the origin of the species and genetic mechanisms for salinity tolerance in the species are basically unknown. Accordingly, we set out to study evolution divergence events in the Cynodon genome and to identify genes for salinity tolerance. We developed a 604.0 Mb chromosome‐level polyploid genome sequence for bermudagrass ‘A12359’ (n = 18). The C. dactylon genome comprises 2 complete sets of homoeologous chromosomes, each with approximately 30 000 genes, and most genes are conserved as syntenic pairs. Phylogenetic study showed that the initial Cynodon species diverged from Oropetium thomaeum approximately 19.7–25.4 million years ago (Mya), the A and B subgenomes of C. dactylon diverged approximately 6.3–9.1 Mya, and the bermudagrass polyploidization event occurred 1.5 Mya on the African continent. Moreover, we identified 82 candidate genes associated with seven agronomic traits using a genome‐wide association study, and three single‐nucleotide polymorphisms were strongly associated with three salt resistance genes: RAP2‐2, CNG channels, and F14D7.1. These genes may be associated with enhanced bermudagrass salt tolerance. These bermudagrass genomic resources, when integrated, may provide fundamental insights into evolution of diploid and tetraploid genomes and enhance the efficacy of comparative genomics in studying salt tolerance in Cynodon.
The ℓp$\ell ^p$ norm of the Riesz–Titchmarsh transform for even integer p$p$
Authors: Bañuelos Rodrigo , Kwaśnicki Mateusz 
Published: March 2024

AbstractThe long‐standing conjecture that for the norm of the Riesz–Titchmarsh discrete Hilbert transform is the same as the norm of the classical Hilbert transform, is verified when or , for . The proof, which is algebraic in nature, depends in a crucial way on the sharp estimate for the norm of a different variant of this operator for the full range of . The latter result was recently proved by the authors (Duke Math. J. 168 (2019), no. 3, 471–504).
A Grassroots Initiative to Engage Classroom Teachers in Increasing Physical Activity
Authors: Orendorff Karie L. , Merica Christopher B. , Egan Cate A. 
Published: March 2024

Purpose: Classroom-based physical activity (PA) provides students the opportunity to achieve PA recommendations. However, limited research has examined grassroots efforts for classroom-based PA. The purpose of this study was to share the story of a grassroots initiative to increase PA during school, titled the 150 Project. Methods: Narrative inquiry was used to draw on participants shared experiences to bring the story into existence. Individual interviews were conducted (n = 4, project developers; n = 9, elementary classroom teachers). Interview data were coded to reveal connections and relationships between the participants’ stories to form a narrative. Results: The narrative is told by explaining (a) challenge (achieve PA recommendations), (b) action steps (project design), (c) outcomes (student, teacher, and school), and (d) moral of the story (need valid data and increased advocacy for during-school PA). Discussion/Conclusion: The 150 Project successfully trained classroom teachers to increase PA and advocate for PE, but the project is unsustainable without additional support systems.
The functional small RNA interactome reveals targets for the vancomycin-responsive sRNA RsaOI in vancomycin-tolerant
Staphylococcus aureus
Authors: Wu Winton , Pang Chi Nam Ignatius , Mediati Daniel G. , Tree Jai Justin 
Published: March 2024

ABSTRACT

Small RNAs have been found to control a broad range of bacterial phenotypes including tolerance to antibiotics. Vancomycin tolerance in multidrug resistance
Staphylococcus aureus
is correlated with dysregulation of small RNAs although their contribution to antibiotic tolerance is poorly understood. RNA-RNA interactome profiling techniques are expanding our understanding of sRNA-mRNA interactions in bacteria; however, determining the function of these interactions for hundreds of sRNA-mRNA pairs is a major challenge. At steady-state, protein and mRNA abundances are often highly correlated and lower than expected protein abundance may indicate translational repression of an mRNA. To identify sRNA-mRNA interactions that regulate mRNA translation, we examined the correlation between gene transcript abundance, ribosome occupancy, and protein levels. We used the machine learning technique self-organizing maps (SOMs) to cluster genes with similar transcription and translation patterns and identified a cluster of mRNAs that appeared to be post-transcriptionally repressed. By integrating our clustering with sRNA-mRNA interactome data generated in vancomycin-tolerant
S. aureus
by RNase III-CLASH, we identified sRNAs that may be mediating translational repression. We have confirmed sRNA-dependant post-transcriptional repression of several mRNAs in this cluster. Two of these interactions are mediated by RsaOI, a sRNA that is highly upregulated by vancomycin. We demonstrate the regulation of HPr and the cell-wall autolysin Atl. These findings suggest that RsaOI coordinates carbon metabolism and cell wall turnover during vancomycin treatment.

IMPORTANCE

The emergence of multidrug-resistant
Staphylococcus aureus
(MRSA) is a major public health concern. Current treatment is dependent on the efficacy of last-line antibiotics like vancomycin. The most common cause of vancomycin treatment failure is strains with intermediate resistance or tolerance that arise through the acqusition of a diverse repertoire of point mutations. These strains have been shown to altered small RNA (sRNA) expression in response to antibiotic treatment. Here, we have used a technique termed RNase III-CLASH to capture sRNA interactions with their target mRNAs. To understand the function of these interactions, we have looked at RNA and protein abundance for mRNAs targeted by sRNAs. Messenger RNA and protein levels are generally well correlated and we use deviations from this correlation to infer post-transcriptional regulation and the function of individual sRNA-mRNA interactions. Using this approach we identify mRNA targets of the vancomycin-induced sRNA, RsaOI, that are repressed at the translational level. We find that RsaOI represses the cell wall autolysis Atl and carbon transporter HPr suggestion a link between vancomycin treatment and suppression of cell wall turnover and carbon metabolism.
Diagnosis of fasciolosis antibodies in Brazilian cattle through ELISA employing both native and recombinant antigens
Authors: Drescher Guilherme , dos Santos Hellen Geremias , Pinto Mariane Marques da Guarda , Morello Luis Gustavo , Figueiredo Fabiano Borges 
Published: March 2024

ABSTRACT

Bovine fasciolosis is a parasitic disease with a global reach. Coprological based on egg detection in fecal samples and liver inspection to evaluate the presence of the parasite is currently the gold standard for diagnosing chronic fasciolosis in cattle. However, these techniques are labor-intensive and ineffective during the acute phase of the disease. Serodiagnosis using native and recombinant antigens has become an interesting alternative in efforts to identify cattle fasciolosis. We evaluated cattle from abattoir (
n
= 139) and farms (
n
= 500) through liver inspection and coprological examination, respectively. Our laboratory team optimized and validated enzyme-linked immunosorbent assay tests based on somatic antigen, excretory/secretory proteins, and the recombinant antigen cathepsin L-1 to detect serum antibodies against fasciolosis in cattle. For animals from abattoir, 10 were positive for fasciolosis according to liver inspection. Both
Fh
ES and
Fh
rCL-1 presented an area under the receiver operating characteristic (AUROC) curve of 0.80, with a sensitivity of 0.80 (95% CI: 0.46–0.95) and 0.70 (95% CI: 0.38–0.90) and specificity of 0.81 (95% CI: 0.73–0.87) and 0.87 (95% CI: 0.80–0.92), respectively. For those cattle from farms, 28 were positive only for fasciolosis according to coprological examination. In this scenario,
Fh
ES gave the best performance, with an AUROC of 0.84, sensitivity of 0.79 (95% CI: 0.60–0.90), and specificity of 0.86 (95% CI: 0.82–0.89). In conclusion, our study highlights the potential of serodiagnosis for accurately screening cattle fasciolosis. The promising sensitivity and specificity values of
Fh
ES when compared to liver inspection or coprological examination enhance its importance for cattle fasciolosis diagnosis.

IMPORTANCE
The aim of this article was to identify antibodies against fasciolosis in cattle in Brazil. The methodology was reproduced in our laboratory and applied for the first time to the Brazilian cattle herd. The antigens tested can be used as a screening test and thus speed up the diagnosis of bovine fascioliasis.
Pain management effectiveness in advanced cancer: palliative care unit inpatient study
Authors: Sampaio Simone Garruth dos Santos Machado , Costa Maria Fernanda Fernandes Duarte , Bilobran Marcela Amitrano , Muniz Andrezza Helena Regadas , Chelles Patrícia Almeida , Souza Julia Werneck Paulino Soares , de Oliveira Livia Costa 
Published: March 2024

ObjectivesThe aim of this study is to evaluate pain management adequacy based on the Pain Management Index (PMI), and its association with the Brief Pain Inventory (BPI) in advanced cancer inpatients to a palliative care unit.MethodsThis is a quantitative study concerning advanced cancer inpatients in a specialised palliative care unit between June 2021 and February 2022. The BPI was applied, and analgesia was observed on the first (D1), third (D3) and seventh (D7) day of hospitalisation. Adequate analgesia was considered when PMI≥0.ResultsA total of 104 patients were evaluated on D1, 68 on D3 and 45 on D7, with a mean age of 53.6 years (SD±14.1), most of them female (65.4%), with the most frequent primary tumour site located in the gastrointestinal tract (22.1%). The observed analgesia was adequate (PMI≥0) in 52.9% of all patients on D1, 95.6% on D3 and 100% on D7 (p value=0.012). The number of patients with moderate to severe pain interference in general activities (p value 0.012), mood (p value 0.014), walking ability (p value 0.047), normal work (p value 0.038) and pleasure of living (p value 0.025) decreased during hospitalisation.ConclusionsPain is a prevalent and impacting symptom in patients undergoing palliative care. Thus, objective analgesic adequacy assessments in specialised services are required. These findings reinforce the importance of effective pain control and corroborate the importance of employing objective tools in evaluating medical services and improving quality of life of patients.
Ethical dilemmas for palliative care nurses: systematic review
Authors: Geng Shuwan , Zhang Lei , Zhang Quan , Wu Yijin 
Published: March 2024

BackgroundNurses play a unique and critical role in palliative care, and it is noteworthy that nurses often encounter ethical dilemmas in this field.ObjectiveThis review aims to conduct a summarised synthesis of the latest research on the ethical considerations nurses faced in palliative care.MethodsWe conducted a rigorous systematic review of relevant existing studies published in high-quality English peer-reviewed journals from January 2017 to July 2023. We identified a total of 4492 articles (1029 in Web of Science, 1570 in PubMed and 1893 in Science Direct). Out of these, only 13 studies met the inclusion criteria.ResultsFollowing the thematic analysis, the ethical considerations reported in these 13 studies were grouped into three main themes and four subthemes: ethical issues in communication (ethical issues in communication with patients, ethical issues in communication with families), ethical issues in decision-making (autonomy, dignity) and moral distress in palliative care.ConclusionThis study elaborated on the ethical challenges faced by nurses in their communication with patients and families as well as decision-making and analysed the causes and effects of ethical distress, hoping to give a hand to ethical issues for nurses’ work in palliative care.
Light dark matter search using a diamond cryogenic detector
Authors:   CRESST Collaboration, Angloher G. , Banik S. , Benato G. , Bento A. , Bertolini A. , Breier R. , Bucci C. , Burkhart J. , Canonica L. , D’Addabbo A. , Lorenzo S. Di , Einfalt L. , Erb A. , Feilitzsch F. v. , Fichtinger S. , Fuchs D. , Garai A. , Ghete V. M. , Gorla P. , Guillaumon P. V. , Gupta S. , Hauff D. , Jes̆kovský M. , Jochum J. , Kaznacheeva M. , Kinast A. , Kluck H. , Kraus H. , Kuckuk S. , Langenkämper A. , Mancuso M. , Marini L. , Mauri B. , Meyer L. , Mokina V. , Olmi M. , Ortmann T. , Pagliarone C. , Pattavina L. , Petricca F. , Potzel W. , Povinec P. , Pröbst F. , Pucci F. , Reindl F. , Rothe J. , Schäffner K. , Schieck J. , Schönert S. , Schwertner C. , Stahlberg M. , Stodolsky L. , Strandhagen C. , Strauss R. , Usherov I. , Wagner F. , Willers M. , Zema V. 
Published: March 2024

AbstractDiamond operated as a cryogenic calorimeter is an excellent target for direct detection of low-mass dark matter candidates. Following the realization of the first low-threshold cryogenic detector that uses diamond as absorber for astroparticle physics applications, we now present the resulting exclusion limits on the elastic spin-independent interaction cross-section of dark matter with diamond. We measured two 0.175 g CVD (Chemical Vapor Deposition) diamond samples, each instrumented with a Transition Edge Sensor made of Tungsten (W-TES). Thanks to the energy threshold of just 16.8 eV of one of the two detectors, we set exclusion limits on the elastic spin-independent interaction of dark matter particles with carbon nuclei down to dark matter masses as low as 0.122 GeV/c$$^2$$

2

. This work shows the scientific potential of cryogenic detectors made from diamond and lays the foundation for the use of this material as target for direct detection dark matter experiments.
Paradoxical Activation of Oncogenic Signaling as a Cancer Treatment Strategy
Authors: Dias Matheus Henrique , Friskes Anoek , Wang Siying , Fernandes Neto Joao M. , van Gemert Frank , Mourragui Soufiane , Papagianni Chrysa , Kuiken Hendrik J. , Mainardi Sara , Alvarez-Villanueva Daniel , Lieftink Cor , Morris Ben , Dekker Anna , van Dijk Emma , Wilms Lieke H.S. , da Silva Marcelo S. , Jansen Robin A. , Mulero-Sánchez Antonio , Malzer Elke , Vidal August , Santos Cristina , Salazar Ramón , Wailemann Rosangela A.M. , Torres Thompson E.P. , De Conti Giulia , Raaijmakers Jonne A. , Snaebjornsson Petur , Yuan Shengxian , Qin Wenxin , Kovach John S. , Armelin Hugo A. , te Riele Hein , van Oudenaarden Alexander , Jin Haojie , Beijersbergen Roderick L. , Villanueva Alberto , Medema Rene H. , Bernards Rene 
Published: March 2024

Abstract
Cancer homeostasis depends on a balance between activated oncogenic pathways driving tumorigenesis and engagement of stress response programs that counteract the inherent toxicity of such aberrant signaling. Although inhibition of oncogenic signaling pathways has been explored extensively, there is increasing evidence that overactivation of the same pathways can also disrupt cancer homeostasis and cause lethality. We show here that inhibition of protein phosphatase 2A (PP2A) hyperactivates multiple oncogenic pathways and engages stress responses in colon cancer cells. Genetic and compound screens identify combined inhibition of PP2A and WEE1 as synergistic in multiple cancer models by collapsing DNA replication and triggering premature mitosis followed by cell death. This combination also suppressed the growth of patient-derived tumors in vivo. Remarkably, acquired resistance to this drug combination suppressed the ability of colon cancer cells to form tumors in vivo. Our data suggest that paradoxical activation of oncogenic signaling can result in tumor-suppressive resistance.
Significance: A therapy consisting of deliberate hyperactivation of oncogenic signaling combined with perturbation of the stress responses that result from this is very effective in animal models of colon cancer. Resistance to this therapy is associated with loss of oncogenic signaling and reduced oncogenic capacity, indicative of tumor-suppressive drug resistance.
Transformational Leadership and Crisis Management Practices of Cebu Technological University-Tuburan
Authors: Maruhom Acmad P. , Minoza Joemar T. , Zosa Leo T. 
Published: March 2024

In making important decisions, especially during times of crisis, it is likely that leadership style cannot be disregarded (Faeq & Ismael, 2022). This study aimed at determining the transformational leadership style of school administrators and its influence to the crisis management practices of CTU as a higher education institution utilizing quantitative research focusing on descriptive survey where it used a survey questionnaire in order to describe the demographic profile to the respondents, transformational leadership style of the school administrators and the effective implementation of crisis management. Respondents were chosen using the sample determination on Slovin formula. Data were collected using the adopted questionnaire from Donmez and Toker’s (2017) and Crises Management Practices adopted from The change leader, Inc. (2007). It was revealed that age and gender are diverse, probationary employees are greater in number, new and rank and file employees dominates the workforce. Furthermore, transformational leadership styles are evident among administrators, and crisis management practices are well-implemented. Gender and civil status have no direct influence to the perceived transformational leadership styles, but age, employment status, length of service and current position does. Transformational leadership significantly influence crisis management practices in CTU-Tuburan. It can be concluded that sound decision can be made when leaders possess transformational leadership style. Hence, this calls for sustainability and consistency from the top management.