bluuebunny/crossref_metadata_2025_split huggingface dataset:
Small-volume resuscitation with hyperoncotic albumin: a systematic review of randomized clinical trials
Authors: Jacob Matthias , Chappell Daniel , Conzen Peter , Wilkes Mahlon M , Becker Bernhard F , Rehm Markus 
Published: March 2008

Abstract
Background
Small-volume resuscitation can rapidly correct hypovolemia. Hyperoncotic albumin solutions, long in clinical use, are suitable for small-volume resuscitation; however, their clinical benefits remain uncertain.

Methods
Randomized clinical trials comparing hyperoncotic albumin with a control regimen for volume expansion were sought by multiple methods, including computer searches of bibliographic databases, perusal of reference lists, and manual searching. Major findings were qualitatively summarized. In addition, a quantitative meta-analysis was performed on available survival data.

Results
In all, 25 randomized clinical trials with a total of 1,485 patients were included. In surgery, hyperoncotic albumin preserved renal function and reduced intestinal edema compared with control fluids. In trauma and sepsis, cardiac index and oxygenation were higher after administration of hydroxyethyl starch than hyperoncotic albumin. Improved treatment response and renal function, shorter hospital stay and lower costs of care were reported in patients with liver disease receiving hyperoncotic albumin. Edema and morbidity were decreased in high-risk neonates after hyperoncotic albumin administration. Disability was reduced by therapy with hyperoncotic albumin in brain injury. There was no evidence of deleterious effects attributable to hyperoncotic albumin. Survival was unaffected by hyperoncotic albumin (pooled relative risk, 0.95; 95% confidence interval 0.78 to 1.17).

Conclusion
In some clinical indications, randomized trial evidence has suggested certain benefits of hyperoncotic albumin such as reductions in morbidity, renal impairment and edema. However, further clinical trials are needed, particularly in surgery, trauma and sepsis.
Cardiovascular response to dobutamine stress predicts outcome in severe sepsis and septic shock
Authors: Kumar Anand , Schupp Elizabeth , Bunnell Eugene , Ali Amjad , Milcarek Barry , Parrillo Joseph E 
Published: March 2008

Abstract
Introduction
During septic shock, resistance to the haemodynamic effects of catecholamine vasopressors and inotropes is a well-recognised marker of mortality risk. However, the specific cardiovascular or metabolic response elements that are most closely associated with outcome have not been well defined. The objective of this study was to assess cardiovascular and metabolic responses to dobutamine as correlates of outcome in patients with severe sepsis or septic shock.

Methods
A prospective, non-randomised, non-blinded interventional study of graded dobutamine challenge (0, 5, 10, and 15 μg/kg/min) in adult patients who had undergone pulmonary artery catheterisation within 48 hours of onset of severe sepsis or septic shock (8 survivors/15 non-survivors) was performed. Radionuclide cineangiography during graded infusion was used to determine biventricular ejection fractions at each increment of dobutamine.

Results
In univariate analysis, a variety of cardiovascular or haemodynamic and oxygen transport or metabolic variables (at the point of maximum cardiac index response for a given subject) were associated with survival including: increased stroke volume index (p = 0.0003); right ventricular end-diastolic volume index (p = 0.0047); left ventricular stroke work index (p = 0.0054); oxygen delivery index (p = 0.0084); cardiac index (p = 0.0093); systolic blood pressure/left ventricular end-systolic volume index ratio (p = 0.0188); left ventricular ejection fraction (p = 0.0160); venous oxygen content (p = 0.0208); mixed venous oxygen saturation (p = 0.0234); pulse pressure (p = 0.0403); decreased pulmonary artery diastolic pressure (p = 0.0133); systemic vascular resistance index (p = 0.0154); extraction ratio (p = 0.0160); and pulmonary vascular resistance index (p = 0.0390). Increases of stroke volume index of greater than or less than 8.5 mL/m2 were concordant with survival or death in 21 of 23 cases. Multivariate profile construction showed stroke volume index as the dominant discriminating variable for survival with the systolic blood pressure/left ventricular end-systolic volume index ratio alone among all other variables significantly improving the model.

Conclusion
Survivors maintain cardiac responsiveness to catecholamine stimulation during septic shock. Survival from severe sepsis or septic shock is associated with increased cardiac performance and contractility indices during dobutamine infusion. Further studies are required to determine whether these parameters are predictive of outcome in a larger severe sepsis/septic shock population.
Gene expression-based screening for inhibitors of PDGFR signaling
Authors: Antipova Alena A , Stockwell Brent R , Golub Todd R 
Published: March 2008

AbstractHere we describe a proof-of-concept experiment designed to explore the possibility of using gene expression-based high-throughput screening (GE-HTS) to find inhibitors of a signaling cascade, using platelet derived growth factor receptor (PDGFR) signaling as the example. The previously unrecognized ability of aurintricarboxylic acid to inhibit PDGFR signaling, discovered through a screen of 1,739 compounds, demonstrates the feasibility and generalizability of GE-HTS for the discovery of small molecule modulators of any signaling pathway of interest.
Contribution of viral and cellular cytokines to Kaposi’s sarcoma-associated herpesvirus pathogenesis
Authors: Gasperini Paola , Sakakibara Shuhei , Tosato Giovanna 
Published: March 2008

AbstractKaposi’s sarcoma (KS)-associated herpesvirus is associated with the proliferative/malignant disorders KS, primary effusion lymphoma (PEL), and multicentric Castleman’s disease (MCD) in patients with AIDS. In spite of recent advances in the treatment of KS, PEL and MCD represent therapeutic challenges. Recent advances in dissecting the pathogenesis of these diseases have indicated that the viral cytokine IL-6 and the cellular cytokines/growth factors IL-10, IL-6, stromal cell-derived factor 1, and vascular endothelial growth factor are important contributors to the growth, survival, and spread of PEL and MCD and are therefore potential targets for drug development.
Double-Blind, Randomized Placebo Controlled Trial of Fulvestrant Compared With Exemestane After Prior Nonsteroidal Aromatase Inhibitor Therapy in Postmenopausal Women With Hormone Receptor–Positive, Advanced Breast Cancer: Results From EFECT
Authors: Chia Stephen , Gradishar William , Mauriac Louis , Bines Jose , Amant Frederic , Federico Miriam , Fein Luis , Romieu Gilles , Buzdar Aman , Robertson John F.R. , Brufsky Adam , Possinger Kurt , Rennie Pamela , Sapunar Francisco , Lowe Elizabeth , Piccart Martine 
Published: March 2008

Purpose The third-generation nonsteroidal aromatase inhibitors (AIs) are increasingly used as adjuvant and first-line advanced therapy for postmenopausal, hormone receptor–positive (HR+) breast cancer. Because many patients subsequently experience progression or relapse, it is important to identify agents with efficacy after AI failure. Materials and Methods Evaluation of Faslodex versus Exemestane Clinical Trial (EFECT) is a randomized, double-blind, placebo controlled, multicenter phase III trial of fulvestrant versus exemestane in postmenopausal women with HR+ advanced breast cancer (ABC) progressing or recurring after nonsteroidal AI. The primary end point was time to progression (TTP). A fulvestrant loading-dose (LD) regimen was used: 500 mg intramuscularly on day 0, 250 mg on days 14, 28, and 250 mg every 28 days thereafter. Exemestane 25 mg orally was administered once daily. Results A total of 693 women were randomly assigned to fulvestrant (n = 351) or exemestane (n = 342). Approximately 60% of patients had received at least two prior endocrine therapies. Median TTP was 3.7 months in both groups (hazard ratio = 0.963; 95% CI, 0.819 to 1.133; P = .6531). The overall response rate (7.4% v 6.7%; P = .736) and clinical benefit rate (32.2% v 31.5%; P = .853) were similar between fulvestrant and exemestane respectively. Median duration of clinical benefit was 9.3 and 8.3 months, respectively. Both treatments were well tolerated, with no significant differences in the incidence of adverse events or quality of life. Pharmacokinetic data confirm that steady-state was reached within 1 month with the LD schedule of fulvestrant. Conclusion Fulvestrant LD and exemestane are equally active and well-tolerated in a meaningful proportion of postmenopausal women with ABC who have experienced progression or recurrence during treatment with a nonsteroidal AI.
Plasma Isoflavone Level and Subsequent Risk of Breast Cancer Among Japanese Women: A Nested Case-Control Study From the Japan Public Health Center-Based Prospective Study Group
Authors: Iwasaki Motoki , Inoue Manami , Otani Tetsuya , Sasazuki Shizuka , Kurahashi Norie , Miura Tsutomu , Yamamoto Seiichiro , Tsugane Shoichiro 
Published: March 2008

PurposeBecause they have large variations in consumption, Asian countries are suitable settings for studies of the effect of relatively high-dose isoflavone intake on breast cancer risk. Nevertheless, no prospective study from Asia has assessed blood or urine levels as biomarkers of isoflavone intake.Patients and MethodsA total of 24,226 women ages 40 to 69 years in the Japan Public Health Center–based prospective study who responded to the baseline questionnaire and provided blood in 1990 to 1995 were observed to December 2002. During a mean 10.6 years of follow-up, 144 patients newly diagnosed with breast cancer were identified. Two matched controls for each patient were selected from the cohort. Isoflavone levels were assessed by plasma level and food frequency questionnaire, and the odds ratio of breast cancer according to isoflavone level was estimated using a conditional logistic regression model.ResultsWe found a statistically significant inverse association between plasma genistein and risk of breast cancer, but no association for plasma daidzein. Adjusted odds ratios for the highest versus lowest quartile of plasma level were 0.34 for genistein (95% CI, 0.16 to 0.74; P for trend, .02) and 0.71 for daidzein (95% CI, 0.35 to 1.44; P for trend, .54). Median plasma genistein values in the control group were 31.9 ng/mL for the lowest and 353.9 ng/mL for the highest quartile groups. Regarding dietary intake of isoflavones, nonsignificant inverse associations were observed for both genistein and daidzein.ConclusionThis nested case-control study found an inverse association between plasma genistein and the risk of breast cancer in Japan.
Randomized Phase II Adjuvant Trial of Dose-Dense Docetaxel Before or After Doxorubicin Plus Cyclophosphamide in Axillary Node-Positive Breast Cancer
Authors: Puhalla Shannon , Mrozek Ewa , Young Donn , Ottman Susan , McVey Anne , Kendra Kari , Merriman Nancy J. , Knapp Mark , Patel Taral , Thompson Mark E. , Maher James F. , Moore Timothy D. , Shapiro Charles L. 
Published: March 2008

Purpose An anthracycline-based combination followed by, or combined with, a taxane is the sequence used in most adjuvant chemotherapy regimens. We hypothesized that administering the taxane before the anthracycline combination would be associated with fewer dose reductions and delays than the reverse sequence. To test this hypothesis, a randomized phase II multicenter adjuvant chemotherapy trial was performed. Patients and Methods Fifty-six patients with axillary node-positive, nonmetastatic breast cancer were randomly assigned either to group A (docetaxel [DOC] 75 mg/m2 intravenously [IV] every 14 days for four cycles followed by doxorubicin 60 mg/m2 and cyclophosphamide 600 mg/m2 [AC] IV every 14 days for four cycles); or to group B (AC followed by DOC) at the identical doses and schedule. Pegfilgrastim 6 mg subcutaneous injection was administered 1 day after the chemotherapy in all treatment cycles. The primary objective was to administer DOC without dose reductions or delays before or after AC and calculate the relative dose intensity (RDI) of DOC and AC. Results The majority of toxicities were grade 0 to 2 irrespective of sequence. The RDI for DOC was 0.96 and 0.82, respectively, in groups A (DOC followed by AC) and B (AC followed by DOC), with more frequent dose reductions occurring in group B (46% v 18%). The RDI for AC was 0.95 and 0.98 in groups A and B, respectively. Conclusion The administration of DOC before AC results in fewer DOC dose reductions and a higher RDI than the reverse sequence. Larger trials evaluating the sequence of DOC before anthracyclines are justified.
Age-Related Changes in the Osteogenic Differentiation Potential of Mouse Bone Marrow Stromal Cells
Authors: Zhang Weixi , Ou Guomin , Hamrick Mark , Hill William , Borke James , Wenger Karl , Chutkan Norman , Yu Jack , Mi Qing-Sheng , Isales Carlos M , Shi Xing-Ming 
Published: March 2008

Abstract
Age-dependent bone loss has been well documented in both human and animal models. Although the underlying causal mechanisms are probably multifactorial, it has been hypothesized that alterations in progenitor cell number or function are important. Little is known regarding the properties of bone marrow stromal cells (BMSCs) or bone progenitor cells during the aging process, so the question of whether aging alters BMSC/progenitor osteogenic differentiation remains unanswered. In this study, we examined age-dependent changes in bone marrow progenitor cell number and differentiation potential between mature (3 and 6 mo old), middle-aged (12 and 18 mo old), and aged (24 mo old) C57BL/6 mice. BMSCs or progenitors were isolated from five age groups of C57BL/6 mice using negative immunodepletion and positive immunoselection approaches. The osteogenic differentiation potential of multipotent BMSCs was determined using standard osteogenic differentiation procedures. Our results show that both BMSC/progenitor number and differentiation potential increase between the ages of 3 and 18 mo and decrease rapidly thereafter with advancing age. These results are consistent with the changes of the mRNA levels of osteoblast lineage-associated genes. Our data suggest that the decline in BMSC number and osteogenic differentiation capacity are important factors contributing to age-related bone loss.
The Impact of Programs to Increase Contraceptive Use Among Adult Women: A Review of Experimental and Quasi‐Experimental Studies
Authors: Kirby Douglas 
Published: March 2008

CONTEXT:  Because rates of unintended pregnancy, abortion and unintended birth are very high among adult women in the United States, it is important to identify interventions that can increase contraceptive use in this population. METHODS:  PubMed, PsycINFO and POPLINE were searched for experimental or quasi‐experimental studies published between 1990 and 2005 that evaluated policies or programs designed to increase contraceptive use or reduce pregnancy among adult women in the United States. In addition, relevant journals were searched, experts were asked to provide further citations and several subsequently published articles were included. RESULTS:  Only 11 studies that assessed programs, and none that assessed policies, were found. The evaluated interventions offered pregnancy and STD prevention counseling (one study); provided contraceptives in settings other than family planning clinics (two studies); had women initiate contraceptive use during the medical visit (two studies); provided advance supplies of emergency contraception (four studies); or implemented systems to remind injectable contraceptive users about their next injection (two studies). The interventions generally had positive, albeit short‐term, effects on contraceptive use; none reduced pregnancy rates. Programs that gave women a contraceptive during the visit were the most effective at increasing method use. Advance provision of emergency contraception increased the likelihood of its use and did not affect regular contraceptive use. CONCLUSIONS:  Very few studies have evaluated interventions to increase contraceptive use among adult women. A research plan that rigorously assesses the impact of different approaches to increasing contraceptive use among adult women should be an integral part of any long‐term effort to prevent unintended pregnancy in the United States.
Cultural proximity in TV entertainment: An eight-country study on the relationship of nationality and the evaluation of U.S. prime-time fiction
Authors: Trepte Sabine 
Published: March 2008

Abstract
In previous research, cultural proximity has been operationalized by ‘hard facts’ such as geographical distance, the exchange of goods or persons (tourists and immigrants) and the similarity of political systems. This article will try to complement current work in the field by suggesting a new operationalization derived from Hofstede's (1991) cultural dimensions. A survey was conducted in eight countries with a student sample (N = 325) to find out if international audiences which resemble each other in terms of Hofstede's (1991) cultural dimensions have similar attitudes towards U.S. prime-time fictional programming. The results show that Hofstede's four cultural dimensions significantly differentiate between the U.S.A., Asian and European countries in a student population. However, operationalizations based on geographical distance allow a better differentiation between nation-states in terms of how they evaluate U.S. fiction. It will be discussed whether cultural dimensions in general are able to measure cultural proximity.
A case for an integrative view on affect regulation through media usage
Authors: Schramm Holger , Wirth Werner 
Published: March 2008

Abstract
Zillmann's mood-management theory (Zillmann, 1988) has acquired a prominent place in media psychology and makes reliable predictions about people's hedonistically motivated mood regulation via entertainment offerings. However, the full potential for explaining affect regulation through media usage has not been exhausted so far. Therefore, we aim at an integrative view of the field based on empirical findings from communication studies as well as on the background of contemporary theories of mood (regulation) and emotion (regulation). The purpose of this analysis is to argue towards an integrative theoretical perspective which considers both unconscious and conscious/reflected processes of affect regulation through media, supplements the hedonistic motive with other non-hedonistic, instrumental motives of affect regulation, looks at selection behavior as well as at other behavioral and cognitive strategies of affect regulation, and encompasses individual attributes (particularly those with affinity to affects).
Telling what yesterday's news might be tomorrow: Modeling media dynamics
Authors: Hollanders David , Vliegenthart Rens 
Published: March 2008

Abstract
In this article, we discuss the use of time series models in communication research. More specifically, we consider autoregressive and moving-average processes, which together constitute the autoregressive integrated moving average-framework (ARIMA). This approach provides a comprehensive framework to deal with the essential issue of stationarity and to model the dynamics of any time series by estimating the autocorrelation structure. Underlying the models are questions as to what extent news tends to reproduce itself and how news flows adjust after deviations from the normal news stream. The data illustrating the models consist of visibility-scores of the immigration issue in Dutch national newspapers. The empirical analysis demonstrates that the impact of immigration figures on this visibility is not significant when the ARIMA-framework is applied, while an analysis using OLS suggests a positive influence.
ICT performance in processes of knowledge sharing in organizations: A review of literature
Authors: Nelissen Paul , Wenneker Marieke , van Selm Martine 
Published: March 2008

Abstract
The purpose of this paper is to theoretically explore in what ways Information and Communication Technology (ICT) corresponds with knowledge sharing in organizations. We will address the research question: “What notions and relationships have been proposed in the literature regarding ICT use and knowledge sharing?” In order to draw connecting lines between different bodies of literature, we developed two notions of ICT performance as a guiding principle in reviewing the literature. On the one hand, ICT is portrayed as a guide that moulds ways of knowledge sharing, and on the other hand ICT is described as a facilitator that follows existing knowledge sharing processes in organizations. The two types of ICT performance offer a tool with which approaches and perspectives on ICT in processes of knowledge sharing can be interconnected and displayed in one overview. This systematic research overview that connects separate notions and ideas coming from different disciplines results in a synthesis of research questions that are relevant for future research on the role of ICT in knowledge sharing in organizations.
Prediction of the Fatigue Limit of Prestrained Carbon Steel Under Tensile Mean Stress
Authors: Kang Minwoo , Irisa Kentaro , Aono Yuuta , Noguchi Hiroshi 
Published: March 2008

Abstract
The effect of tensile mean stress on the fatigue limit of carbon steel was investigated. Annealed 0.1 % and 0.5 % carbon steel specimens were subjected to monotonic tension to produce prestrain. Fatigue tests were performed using a servohydraulic fatigue test machine. The experimental results showed that tensile mean stress degraded the fatigue limit. However, the tensile mean stress did not affect the decrease in the surface hardness as a result of fatigue loading for the specimen without a defect. In the case of the specimen with a defect, the decrease in the hardness was small and did not depend on the mean stress or stress amplitude. Formulae for predicting the fatigue limit of prestrained carbon steel specimens under tensile mean stress were proposed. The results calculated using the formulae showed good agreement with the experimental results.
Novel Uncertainty-Evaluation Method of Virtual Instrument Small Sample Size
Authors: Leyi Ge , Zhongyu Wang 
Published: March 2008

AbstractOwing to the complication of virtual instrument measurement process, the authors applied Guide to the expression of uncertainty in measurement to evaluate the final measurement-uncertainty. However there are three essential problems that should be solved first: establishing a measurement model, calculating all error sensitivity coefficients, and correlation-coefficient. In order to analyze all random errors of the virtual instrument (VI) measurement chain, in this paper the main structure of VI measurement systems was discussed first. To establish the model of VI small sample measurement, a radial basis function neural network was used, then, based on this model, all error sensitivity coefficients were calculated by some difference equations; to calculate all correlation-coefficient of these error sources, a special arithmetic based on grey system theory was used. In the end, according to a general measurement example, uncertainty-evaluation results of this new method and Monte Carlo method were consistent, and this new method was proved.