bluuebunny/crossref_metadata_2025_split huggingface dataset:
An alternative treatment of anal squamous cell carcinoma: Combined radiotherapy and chemotherapy
Authors: You Yau‐Tong , Wang Jeng‐Yi , Changchien Chung‐Rong , Chen Jinn‐Shiun , Hsu Kuan Cheng , Tang Reiping , Fan Hong‐Arh 
Published: February 2007

AbstractThe conventional surgical treatment of anal squamous cell carcinoma is abdominoperineal resection. A new approach of combined radiotherapy and chemotherapy has been proposed following the observation of excellent local control. In this retrospective study, 40 cases of primary anal squamous cell carcinoma without distant metastasis were collected between 1979 and 1986 and the individual prognosis of the above two methods of treatment was evaluated. Group I (20 cases) received abdominoperineal resection with or without postoperative radiotherapy. Postoperative radiation was given if regional lymph node biopsy was positive. Group II (20 cases) received combined radiotherapy and chemotherapy with or without wide local excision. Radiation was delivered to the anus, pelvis, and bilateral inguinal nodal areas to a total dose of 5,500 rads. A continuous infusion of 5‐FU was started on day 2 of the irradiation at a dose of 1,000 mg/m2 body surfaceiday for 5 days and a bolus injection of rnitomycin was given on day 2 at a dose of 10 mg/m2 body surface. The second course was given 1 month later to complete the chemotherapy. The wide local excision was performed if the disease still persisted after completion of combined radiotherapy and chemotherapy. All 40 cases were followed up for at least 5 years. All cases (100%) in group I survived 1 year, 18 cases (90%) 2 years, 14 cases (70%) 3 years, 10 cases (50%) 4 years, and 6 cases (30%) 5 years. Twenty cases (100%) in group II survived 1 year, 17 cases (85%) 2 years, 13 cases (65%) 3 years, 8 cases (40%) 4 years, and 5 cases (25%) survived 5 years. All the mortalities in both groups died of distant metastasis or abdominal carcinomatosis. From the above results, the overall survival rate of combined radiotherapy and chemotherapy was not significantly worse than that of convential abdominoperineal resection. In conclusion, combined radiotherapy and chemotherapy may be chosen as an alternative management in treating anal squamous cell carcinoma. © 1993 Wiley‐Liss, Inc.
False negative breast biopsy for palpable mass
Authors: Zitarelli Joseph , Burkhart Linda L. , Weiss Stephen M. 
Published: February 2007

AbstractOpen breast biopsy is considered to be the most reliable method for the diagnosis of breast cancer in patients with palpable masses. Rarely, after a breast biopsy has been reported to be benign, cancer will be identified at the site of the biopsy. Eight patients were reviewed in whom breast cancer was demonstrated at the site of a previously negative biopsy at intervals ranging between 4 months and 3 years after the original, negative biopsy. Several possible explanations exist to account for this occurrence. The surgeon must be aware that the presence of a mass at the site of prior breast biopsy may be an indication for repeat excision. © 1993 Wiley‐Liss, Inc.
Experimental cancer chemotherapy using A liver metastatic model of human colon cancer transplanted into the spleen of severe combined immunodeficient mice
Authors: Kuo Tsong‐Hong , Kubota Tetsuro , Nishibori Hideki , Watanabe Masahiko , Furukawa Toshiharu , Kase Suguru , Tanino Hirokazu , Saikawa Yoshiro , Teramoto Tatsuo , Kitajima Masaki 
Published: February 2007

AbstractWe have developed a liver metastatic model of human colon cancer using severe combined immunodeficient (SCID) mice. Liver metastases were observed in all the SCID mice on day 28 after intrasplenic injection with 5 × 106 dissociated tumor cells of COL‐2‐JCK, a human colon cancer strain serially transplanted in nude mice. When this model was applied for chemotherapeutic experiments, 5‐fluorouracil (5‐FU) demonstrated significant antitumor effects in preventing liver metastases, whereas the efficacy of 5‐FU was limited in the currently used sc‐ip chemosensitivity assay in nude mice. When the human LDH‐5 isozyme was evaluated in the homogenized metastatic liver tissue of SCID mice, a good correlation was obtained between the liver tumor weights and LDH‐5 isozyme, suggesting that it could be a promising quantitative indicator for metastases. This model would be useful for further studies on the treatment of liver metastases of colon cancer. © 1993 Wiley‐Liss, Inc.
CA 19‐9 as a prognostic index after resection for pancreatic cancer
Authors: Sperti Cosimo , Pasquali Claudio , Catalini Sandra , Cappellazzo Francesco , Bonadimani Bruno , Behboo Roubik , Pedrazzoli Sergio 
Published: February 2007

AbstractSerial serum CA 19‐9 assays were performed in 30 consecutive patients who underwent resection for pancreatic cancer. Patients with preoperative CA 19‐9 levels < 200 U/ml had significantly better prognosis than those with CA 19‐9 > 200 Ulml (P < 0.001). Serum tumor marker normalized in 14 patients after tumor resection, and survival in this group was significantly higher than that of patients with persistently elevated CA 19‐9 (P < 0.0001). Prognosis was also influenced by absence of lymph node metastases (P < 0.02) and radicality of resection (P < 0.005). Elevation of serum CA 19‐9 levels after operation well predicted tumor recurrence from 1‐10 months before clinical and radiological evidence. CA 19‐9 determination is useful as a prognostic index after resection for pancreatic carcinoma and as a surveillance test in monitoring the efficacy of treatment. © 1993 Wiley‐Liss, Inc.
Recurrence‐associated mortality in patients with differentiated thyroid carcinoma
Authors: Krausz Yodphat , Uziely Beatrice , Karger Haim , Isacson Ruth , Catane Raphael , Glaser Benjamin 
Published: February 2007

AbstractDifferentiated thyroid carcinoma (DTC) is associated with prolonged natural history, and even recurrent tumor is not necessarily followed by increased mortality. Prognostic factors and different treatment strategies, therefore, are difficult to assess. One hundred and fifty‐seven patients were followed in our clinic. In an attempt to predict mortality from this tumor, we evaluated the risk factors in 36 patients who presented with recurrent disease. Ten of these patients died. Age above 40 years at initial diagnosis was the predominant risk factor associated with 44% mortality after recurrence. Male sex, lack of radioiodine treatment, and distant site of initial recurrence were all associated with a trend towards increased mortality. Tumor histology and local invasion or extent of initial surgical treatment failed to affect mortality. In conclusion, this approach may be used to identify those patients who will die from their disease, despite currently available treatment. It remains to be seen, however, if new treatment protocols can be developed to improve the prognosis of these patients. © 1993 Wiley‐Liss, Inc.
Expression of carcinoembryonic antigen in fresh human gastric cancer cells assessed by flow cytometry
Authors: Tamai Mikiko , Tanimura Hiroshi , Yamaue Hiroki , Iwahashi Makoto , Tsunoda Takuya , Tani Masaji , Noguchi Kohei , Hotta Tsukasa , Arii Kazuo 
Published: February 2007

AbstractThe expression of carcinoembryonic antigen (CEA) by tumor cells from freshly excised human gastric cancers was investigated using flow cytometry (FCM). Highly purified fresh human cancer cells were obtained from solid tumors in 20 patients and from malignant ascites in 6 patients. Thirteen of the 26 tumors were positive for CEA by FCM. CEA expression was more common in well‐differentiated tumors than in poorly differentiated tumors. CEA expression was investigated by both FCM and immuno‐histochemistry in 9 patients, and the two methods agreed in 8 of them. However, quantitative evaluation of CEA expression could only be performed by FCM and not by immunohistochemical staining. FCM could analyze the expression of CEA not only on the cell membrane but also in the cytoplasm, by using gastric cancer cells with or without Triton X‐100 treatment. Thus, this study showed that CEA expression can be determined and evaluated quantitatively by FCM. © 1993 Wiley‐Liss, Inc.
Adjuvant chemotherapy for osteogenic sarcoma of the extremity with sequential adriamycin and cisplatin
Authors: Pathak Anand B. , Advani Suresh H. , Iyer Rajaram S. , Pai Suresh K. , Gopal Ramakrishna , Nadkarni Kanchan S. , Saikia Tapan K. , Kurkure Purna A. , Nair Chandrika N. , Pai Vasant R. , Badhwar Rajesh , Deshpande Raman K. , Desai Prafulla B. , Karakousis Constantine P. 
Published: February 2007

AbstractTwenty‐nine patients with high‐grade nonmetastatic osteogenic sarcoma of the extremities were treated with adjuvant chemotherapy following definitive surgery. Chemotherapy consisted of systemic intravenous Adriamycin and cisplatin in a sequential fashion given for six courses. Nineteen out of 29 patients are alive and continuously disease free over a follow‐up period ranging from 9+ to 30+ months. The relapse‐free survival was 72%, and overall survival for the entire group was 69%. Median survival is not reached yet. Six out of 29 patients relapsed, of which 1 patient is alive for 6+ months after relapse. Three patients died of chemotherapy toxicity. The results were superior to historical controls treated with surgery alone. The need for more aggressive treatment approaches is discussed. © 1993 Wiley‐Liss, Inc.
Hepatic cryosurgery with and without the bair huggers®
Authors: Onik Gary M. , Chambers Nathan , Chernus Steven A. , Zemel Reuben , Atkinson Donald , Weaver M. Lance 
Published: February 2007

AbstractHypothermia is a significant clinical problem during hepatic cryosurgery, which at times causes the procedure to be halted until the patient's body temperature can be raised. This study examines the effects of the Bair Huggerm (a warming device) on body temperature during hepatic cryosurgery. Twenty‐eight cases of hepatic cryosurgery were performed without the Bair Huggerm, while 44 cases included the Bair Huggerm. The lowest mean temperature was significantly lower in the group without the Bair Huggerm® (34.2°C vs. 35.3°C; P < 0.0001). In addition, this group showed a significantly greater mean change in temperature during the procedure (1.81°C vs. 0.73°C; P < 0.0001). No patient in the Bair Hugger® group reached the point of clinically significant hypothermia. In conclusion, the Bair Hugger® is safe and very effective in regulating body temperature and it is an essential piece of equipment performing hepatic cryosurgery. © 1993 Wiley‐Liss, Inc.
Ewing's sarcoma
Authors: Iyer Rajaram S. , Rao S. R. , Gurjal A. , Nair Chandrika N. , Pai Suresh K. , Kurkure Purna A. , Pande Subodh C. , Advani Suresh H. 
Published: February 2007

AbstractBetween 1984–1987, 50 patients with Ewing's sarcoma of the bone were entered on combined modality protocol at Tata Memorial Hospital. Protocol treatment involved induction therapy consisting of 6‐week therapy with vincristine, Adriamycin (doxorubicin), and cyclophosphamide (VDC) followed by local radiotherapy 50 Gy to the involved bone. This was followed for six more cycles of VDC. Five patients had metastatic disease at presentation. Seventy‐six percent (38/50) of patients had disease either at axial or proximal site. With a median follow‐up of 48 months (range 14–87) 21 patients remained alive with disease‐free survival of 38.0% ± 2.5% at 5 years and overall survival of 36.0% ± 2.6% at 5 years. Twentyfive patients relapsed with five patients developing local failure and four local and distant metastasis. Using Lee‐Desu statistical methods, only response to therapy was a significant factor for survival. We conclude that more aggressive therapy with proper selection of local treatment modality including surgery and/or radiotherapy is required to produce more long‐term survival in high‐risk Ewing's sarcoma. © 1993 Wiley‐Liss, Inc.
Malignant arterial tumor embolization
Authors: Chandler Christopher 
Published: February 2007

AbstractMalignant arterial tumor emboli large enough to cause ischemia or organ infarction are a rare, but often fatal, complication of neoplastic disease. The majority of arterial emboli are associated with primary or secondary pulmonary malignancies. The sites where they impact are similar in distribution to arteriosclerotic emboli, and the treatment follows well‐established principles developed for the treatment of arteriosclerotic emboli. The results of embolectomy in accessible sites are very good, thus treatment should always be attempted. A case of a superior mesenteric tumor embolus occurring after pneumonectomy is reported, together with a review of all published cases of arterial tumor emboli of sufficient size to cause organ infarction or ischemia. © 1993 Wiley‐Liss, Inc.
Wound bleeding after head and neck surgery
Authors: Matory Yvedt L. , Spiro Ronald H. 
Published: February 2007

AbstractUsing our head and neck service database, we reviewed 3,200 surgical procedures performed at our institution over a 7‐year period. We identified 54 patients whose surgery was complicated postoperatively by wound bleeding. The procedure most often complicated by wound bleeding was parotidectomy, 1.7% (14 of 510 patients), followed by thyroidectomy, 1.6% (8 of 504 patients), neck dissection combined with other procedures, 1.3% (12 of 885 patients), and neck dissection alone, 1.1% (6 of 534 patients). Bleeding developed in flap donor sites in 2 of 227 patients and followed miscellaneous procedures in 12 others. Thirty‐one patients were treated by reexploration in the operating room, 13 had limited exploration on the ward and 10 were observed with no intervention. There was no difference in wound healing between the three treatment groups. However, mean hospital stay was shortest for patients who had wound exploration in the operating room, 6.2 days, for exploration on the ward, 10.8 days, and 18.9 for those that were observed. Drains had no effect on wound healing or mean hospital stay. © 1993 Wiley‐Liss, Inc.
Immunohistologic analysis of the extracellular matrix components of the fibrous stroma of human colon cancer
Authors: Miura Seiji , Kodaira Susumu , Hosoda Yoichiro 
Published: February 2007

AbstractIn order to elucidate the gross composition of fibrous stroma and to better understand the obstructive nature of advanced human colonic cancers the extracellular matrix components of its stroma were analyzed immunohistologically, emphasizing the process of fibrosis and possible tissue constriction. Collagenous material, identified by Masson's trichrome stain, was distributed mainly in the invasive area, where type I and III collagens and chondroitin 4‐sulfate stained intensely in the periacinar area, and further, fibronectin stained. Conversely, in the invasive area away from tumor acini type III collagen stained weakly and fibronectin not at all. Type V collagen and myofibroblasts stained in the periacinar area and did not stain in the invasive area away from tumor acini, the findings of myofibroblasts being prominent in cases with obstructive type carcinomas. In conclusion, the invasive area, especially the periacinar area, displayed signs of active ongoing fibrosis and tissue contraction, which may be responsible for the genesis of obstructing type colonic carcinomas. © 1993 Wiley‐Liss, Inc.
Photo detection of carcinoma of the colon in a rat model: A pilot study
Authors: von Rueden David G. , McBrearty Francis X. , Clements Barton M. , Woratyla Steven 
Published: February 2007

AbstractPhotodynamic sensitizers are light‐absorbing chemicals that cause photo‐reactions in biologic systems when exposed to light of the proper wavelength. Dihematoporphyrin ethers (DHE) are the active porphyrin derivatives most commonly used as a photosensitizer (Photofrin, QLT). DHE accumulates in tumor tissue and also fluoresces when light activated. A more reliable and less costly screening method for early detection and treatment of colon cancer is needed. The present study was designed to induce adenocarcinoma of the colon in rats with 1,2 dimethylhydrazine (DMH) and attempt to identify tumors early in their evolution by DHE fluorescence. Forty rats were injected with 20 mg/kg of DMH at weekly intervals until sacrifice. Photofrin (3 mg/kg) was injected through the tail vein in each prior to sacrifice. Eight colonic specimens contained invasive adenocarcinoma, seven of which fluoresced when exposed to a Woods lamp. Carcinoma in situ was identified in two specimens by fluorescence, and one fluorescent specimen contained dysplasia. © 1993 Wiley‐Liss, Inc.
Inhibitory effects of a cholecystokinin antagonist, loxiglumide (CR‐1505), on the growth of freshly separated and xenografted human pancreatic cancer
Authors: Morimoto Hideki , Nio Yoshinori , Tsubono Michihiko , Tseng Chen‐Chiu , Kawabata Kazuya , Masai Yoshikazu , Hayashi Hitoshi , Baba Nobuo , Manabe Tadao , Hosokawa Youhei , Tobe Takayoshi 
Published: February 2007

AbstractThe effects of cholecystokinin (CCK) and a CCK antagonist, loxiglumide (CR‐1505), on four freshly separated and six xenografted human pancreatic cancers, were investigated. The level of DNA synthesis in only one of five tested pancreatic cancers was enhanced by CCK at concentrations of 0.01–10 nM, while in the other four cancers DNA synthesis was not affected. The levels of DNA, RNA, and protein synthesis (by 3H‐thymidine, 3H‐uridine, and 3H‐leucine incorporation tests, respectively) in all the tested cancers were dose‐dependently inhibited by loxiglumide at concentrations of 20–2000 μM, and the IC50 of loxiglumide for DNA synthesis in pancreatic cancers was 156 ± 80 μM (means ± SD). The in vivo effect of loxiglumide was assessed using a xenografted line (PC‐HN) transplanted in nude mice. The in vivo 50% lethal dose of loxiglumide for nude mice was about 500 mg/kg. Death was caused by respiratory failure due to severe congestion of the lung after the administration of a large dose of loxiglumide. The growth of a PC‐HN transplanted in the nude mice was significantly inhibited by subcutaneous loxiglumide at 250 mg/kg, twice a day for 28 days, which did not cause death. It is suggested that loxiglumide inhibits the in vivo and in vitro growth of human pancreatic cancer, perhaps independently of its action as a CCK antagonist, and this study also suggests that loxiglumide may be a new type of therapeutic agent to be used for the treatment of human pancreatic cancer. © 1993 Wiley‐Liss, Inc.
Cancer of the male breast presenting as an axillary mass
Authors: Balich Susan M. , Khandekhar Janardan D. , Sener Stephen F. 
Published: February 2007

AbstractThe authors describe a 55‐year‐old man with an axillary mass. Physical examination of the breast was normal, and the patient had no risk factors for cancer of the male breast. A workup for other possible cancers was normal. Excisional biopsy of the mass revealed metastatic adenocarci‐noma. The histology favored a primary breast cancer. The patient had a right modified radical mastectomy. The pathologic examination showed infiltrating ductal adenocarcinoma of the breast. Adjuvant therapy included combination chemotherapy followed by tamoxifen. Physicians must be aware of the differential diagnosis of an unknown primary cancer when it presents as an axillary mass. © 1993 Wiley‐Liss, Inc.
The tikhoff‐linberg procedure in the treatment of sarcomas of the shoulder girdle
Authors: Ham S. John , Hoekstra Harald J. , Eisma Willem H. , Koops Heimen Schraffordt , Oldhoff Jan 
Published: February 2007

AbstractThe majority of patients with soft tissue or bone sarcomas of the upper extremity can be treated today with limb‐saving procedures using combined modality therapies. For patients with a tumor in the shoulder area, sometimes an interscapulothoracic amputation is the only radical surgical treatment. However, in selected cases, in which the tumor does not involve the neurovascular bundle, a limb‐sparing alternative might be the Tikhoff‐Linberg resection. Normal function of the hand and forearm, with reasonable function of the elbow, can be maintained by this procedure. Four case histories are reported. © 1993 Wiley‐Liss, Inc.
Neural cell adhesion molecule (NCAM) and perineural invasion in bile duct cancer
Authors: Seki Hitoshi , Tanaka Jun‐Ichi , Sato Yasuhiko , Kato Yujiro , Umezawa Akiko , Koyama Kenji 
Published: February 2007

AbstractPerineural invasion is associated with tumor spreading and an unfavorable prognosis in a variety of cancers. Recently, neural cell adhesion molecule (NCAM) has been reported to be affinitive to neural tissues, which suggests some relationship between NCAM and perineural invasion. This study was designed to elucidate the role of the expression of NCAM on the development of perineural invasion in bile duct cancer. A histopathologic study was performed on 24 patients with bile duct carcinoma who underwent resections. The overall incidence of NCAM expression in the resected specimen was 66.7% and that of perineural invasion was 87.5%. Furthermore, NCAM expression was shown to be positive in 16 (76%) out of 21 cases in whom perineural invasion was observed. A significant positive correlation was found between the expression of NCAM and perineural invasion in bile duct cancer. These results highlight an important role of NCAM in the development of perineural invasion in bile duct cancer. © 1993 Wiley‐Liss, Inc.
Soft tissue sarcoma: The enigma of local recurrence
Authors: Evans Richard A. 
Published: February 2007

AbstractLocal recurrence following the treatment of soft tissue sarcoma has been long recognized as a grave prognostic sign. Nevertheless, many investigators have recently suggested that local recurrence following limited surgery (“local persistence”) may be a manifestation of a tumor's size and metastatic potential and not a cause of tumor cell dissemination. The author reviewed the experience of several investigators with local persistence. This event was not found to be a threat to survival. The author offers an explanation for this unexpected finding. Soft tissue tumors vary widely in their metastatic potential, and patients also may vary widely in their ability to resist the distant implantation of circulating tumor cells. Patients with a low level of host resistance may be more susceptible to both distant metastases and local persistence, and vice versa. Weaker patients succumb to their initial tumor. Patients who survive the circulating tumor cells from their primary tumor may be immunologically prepared to survive the local persistence of a similar volume of tumor without developing distant disease. © 1993 Wiley‐Liss, Inc.
Pediatric soft tissue sarcomas of nonmyogenic origin
Authors: McCoy David M. , Levine Edward A. , Ferrer Karen , Gupta Tapas K. Das 
Published: February 2007

AbstractNonrhabdomyosarcoma soft tissue sarcomas (NRSTS) are relatively rare tumors, which nonetheless constitute 50% of the soft tissue sarcomas seen in the pediatric population. The prognosis for these tumors is good, with 92% of patients in our series alive and 61% free of their disease at 5 years follow‐up. The most important prognostic factor among our 35 patients was the grade of the tumor. More than 70% of our patients with grade I or II lesions are disease‐free at 5 years, compared to only 39% of patients with grade III lesions. The patients with the best outlook are those who can be treated with surgery alone as the definitive care for this disease. Resection remains the primary treatment modality in NRSTS, whereas, unlike the treatment of rhabdomyosarcomas, the value of radiation therapy and chemotherapy in treating NRSTS remains undefined. © 1993 Wiley‐Liss, Inc.