bluuebunny/crossref_metadata_2025_split huggingface dataset:
Different subtypes of chronic fatigue in childhood cancer survivors: A DCCSS LATER study
Authors: Penson Adriaan , Walraven Iris , Bronkhorst Ewald , Grootenhuis Martha A. , Maurice‐Stam Heleen , Loo Margriet van der Heiden‐van der , Tissing Wim J. E. , van der Pal Helena J. H. , de Vries Andrica C. H. , Bresters Dorine , Ronckers Cécile M. , van den Heuvel‐Eibrink Marry M. , Neggers Sebastian , Versluys Birgitta A. B. , Louwerens Marloes , Pluijm Saskia M. F. , Blijlevens Nicole , van Dulmen‐den Broeder Eline , Kremer Leontien C. M. , Knoop Hans , Loonen Jacqueline ,   the Dutch LATER study group
Published: April 2024

AbstractIntroductionThe aim of the current study was to investigate whether subtypes of chronic fatigue (CF) can be identified in childhood cancer survivors (CCS), and if so, to determine the characteristics of participants with a specific subtype.MethodsParticipants were included from the nationwide DCCSS LATER cohort. The Checklist Individual Strength (CIS) was completed to assess fatigue. Participants with CF (scored ≥35 on the fatigue severity subscale and indicated to suffer from fatigue for ≥6 months) were divided into subgroups using two‐step cluster analysis based on the CIS concentration, motivation, and physical activity subscales. Differences between groups on demographics, psychosocial, lifestyle, and treatment‐related variables were determined using ANOVA and chi‐square analyses (univariable) and multinomial regression analysis (multivariable).ResultsA total of 1910 participants participated in the current study (n = 450 with CF; n = 1460 without CF). Three CF subgroups were identified: Subgroup 1 (n = 133, 29% of participants) had CF with problems in physical activity; Subgroup 2 (n = 111, 25% of participants) had CF with difficulty concentrating; and Subgroup 3 (n = 206, 46% of participants) had multi‐dimensional CF. Compared to Subgroup 1, Subgroup 2 more often reported sleep problems, limitations in social functioning, and less often have more than two comorbidities. Subgroup 3 more often reported depression, sleep problems, a lower self‐esteem, and limitations in social functioning and a lower educational level compared to Subgroup 1.ConclusionDifferent subgroups of CCS with CF can be identified based on fatigue dimensions physical activity, motivation and concentration. Results suggest that different intervention strategies, tailored for each subgroup, might be beneficial.
Study on the durability of compression behavior for glass fiber‐reinforced polypropylene thermoplastic composite bars in various aging environments
Authors: Zhou Ping , Dong Shaoce , Li Chenggao , Kong Deao , Bai Yanbo , Xian Guijun , Yue Qingrui 
Published: April 2024

AbstractIn reinforced concrete structures, GFRP bars are becoming acceptable as internal reinforcement subject to compressive load and hygrothermal environments. The paper presents an experimental study on the compressive behavior, thermodynamic properties, and degradation mechanism of the glass fiber‐reinforced polypropylene (GFRPP) bars after aging in distilled water (DW), alkaline solution (AS) and seawater and sea sand concrete (SWSSC) solution at 21, 40, and 60°C up to 120 days. The effect of specimen assembly methods, and slenderness rations (Lu/Db) on the compressive behavior was evaluated on the control GFRPP bars. After immersion, the compressive strength of the GFRPP bars was significantly affected by the type of solution, immersion time, and temperature. Typically, the compressive strength retention was decreased by 25.8%, 30.0%, and 33.0% at 60°C in DW, AS, and SWSSC solutions, respectively. The degradation mechanism of the compressive behavior of GFRPP bars was revealed through SEM images and FTIR spectroscopy analysis, and the debonding of fiber‐resin interfaces, chemical etching of glass fibers, and changes in polypropylene functional groups were confirmed or discovered. Finally, based on the Arrhenius theory, the long‐term life prediction of compression strength in three typical service environments was conducted to provide the design guideline for reinforcement concrete.Highlights
Effect of specimen assembly and Lu/db on compressive behavior of GFRPP bars
Thermodynamic behavior of the GFRPP bars under different aging environments
Revealed the degradation mechanism of GFRPP bars under hygrothermal environments
Predicted the service life of GFRPP bars in typical service environments
Development of high‐strength carbon fiber/thermoplastic epoxy resin composites and it's recyclability
Authors: Heng Yanqing , Qi Xiaoming , Xu Lu , Yan Yongjie , Ni Qingqing 
Published: April 2024

AbstractThe realization of the recycling of epoxy resin composites has important practical significance for “carbon peak, carbon neutrality” and resource conservation, and recycling. In this study, high‐strength carbon fiber fabric reinforced thermoplastic epoxy (TPE) composites (CFF/TPE) were successfully fabricated by a laminated hot‐pressing process, and both CFF and TPE were efficiently recycled via an ultrasonication‐assisted solvent method. The CFF/TPE composites present mechanical properties (tensile strength: 705 MPa, flexural strength: 711 MPa) by optimizing the process parameters, which are comparable to those of carbon fiber reinforced thermosetting epoxy. Moreover, the tensile strength retention rates of recycled CFF and TPE are 92% and 89%, respectively. The recycled CFF can be completely reprocessed through the same hot‐pressing process, and the recycled CFF/TPE composite exhibited high efficiency reuse and excellent mechanical properties (high strength of reaching 94% of CFF/TPE). This approach provides a new strategy for the facile production of high‐performance carbon fiber reinforced epoxy composites with high efficiency recycling.Highlights
Recyclable carbon fiber fabric reinforced thermoplastic epoxy composites (CFF/TPE) are fabricated by a laminated hot‐pressing process.
The composite exhibits excellent mechanical properties, which is comparable to that of carbon fiber reinforced thermosetting epoxy.
The carbon fiber fabric and thermoplastic epoxy can be efficiently recycled via a simple ultrasonication‐assisted solvent method, and resued.
Registration of ‘FL12034‐10’ oat: A new dual‐purpose disease resistant cultivar for Florida and southern United States
Authors: Babar Md Ali , Harrison Stephen A. , Blount Ann , Barnett Ronald D. , Johnson Jerry , Mergoum Mohamed , Mailhot Daniel J , Murphy J. Paul , Mason Richard E. , Shakiba Ehsan , Ibrahim Amir M. H. , Sutton Russell , Simoneaux Bryan , Boyles Richard , DeWitt Noah , Stancil Brad , Marshall David , Fountain Myron , Klos Kathy Esvelt , Khan Naeem , Wallau Marcelo , Jordan Jr Henry G. , Ma Xuefeng , Arbelaez Juan 
Published: April 2024

Abstract‘FL12034‐10’ (Reg. no. CV‐389, PI 704483), a facultative oat (Avena sativa L.) cultivar, co‐developed by the University of Florida and Louisiana State University Agricultural Center, was released in October 2022. FL12034‐10 was derived from a three‐way cross LA06055SBSBSB‐79/FL11048 F1. It is well adapted across the southern United States and provides producers with a medium‐tall, mid‐season, awnless, white‐glumed, dual‐purpose oat that has high yield potential, good straw strength, and good forage yield. FL12034‐10 was observed to be uniform and stable across environments in the southern United States from 2017 to present. The line possesses a semi‐prostrate growth habit, vigorous growth, and high tillering capacity, and has large leaves that are dark green in color. It expresses moderate‐to‐high levels of resistance to most oat diseases prevalent in the southern United States. The crown and stem rust and Barley yellow dwarf virus ratings (0–9 scale) of FL12034‐10 were 1.7, 0.7, and 1.5, respectively, across different environments. The disease ratings were better than most of the checks. The grain yield average of FL12034‐10 from 41 environments during 2018–2021 was 6437 kg ha−1, which is competitive with check cultivars that are widely used in the southern part of the United States. The forage yield of FL12034‐10 ranged from 2358 to 6617 kg ha−1 (20 environments), which was higher than most of the checks. FL12034‐10 demonstrated better lodging and disease resistance, higher grain yield potential, and higher mid‐winter to late spring season forage yield potential than Horizon 720 and Legend 567 oats released by University of Florida.
Registration of ‘CP 15‐1407’ sugarcane for muck soils
Authors: Islam M. S. , Sandhu Hardev S. , Zhao Duli , Sood Sushma , Momotaz Aliya , Coto Arbelo Orlando , Baltazar Miguel , Davidson R. Wayne , Rounds Elliott 
Published: April 2024

AbstractThe complex hybrid sugarcane (Saccharum spp.) cultivar ‘CP 15‐1407’ (Reg. no. CV‐217; PI 704105) was made available to growers in June 2022 for cultivation on muck soils in Florida. This development took 10 years thanks to collaborative research by the USDA–ARS, the Florida Sugar Cane League Inc., and the University of Florida. It started at Canal Point (CP) as a bi‐parental cross between ‘CP 08‐1110’ (female) and CP 05‐1616 (male). Due to its high stalk weight, adequate disease resistance, higher recoverable sugar, and equivalent cane yield to best check ‘CP 96‐1252’ on muck soils, the Florida Sugarcane Variety Committee recommended releasing CP 15‐1407. It has demonstrated resistance to brown rust, orange rust, sugarcane mosaic, smut, leaf scald, and ratoon stunt and is moderately susceptible to yellow leaf. In late‐stage, on‐farm yield trials, CP 15‐1407 stalk weights were 27.8% heavier than that of CP 96‐1252, while cane yields and economic index (EI) did not differ from CP 96‐1252. Florida sugarcane output and crop sustainability are predicted to benefit from CP 15‐1407's sustained cane production capacity and proven disease resistance.
Differential effects of physiological agonists on the proteome of platelet‐derived extracellular vesicles
Authors: Moon Mitchell J. , Rai Alin , Sharma Prerna , Fang Haoyun , McFadyen James D. , Greening David W. , Peter Karlheinz 
Published: April 2024

AbstractArterial thrombosis manifesting as heart attack and stroke is the leading cause of death worldwide. Platelets are central mediators of thrombosis that can be activated through multiple activation pathways. Platelet‐derived extracellular vesicles (pEVs), also known as platelet‐derived microparticles, are granular mixtures of membrane structures produced by platelets in response to various activating stimuli. Initial studies have attracted interest on how platelet agonists influence the composition of the pEV proteome. In the current study, we used physiological platelet agonists of varying potencies which reflect the microenvironments that platelets experience during thrombus formation: adenosine diphosphate, collagen, thrombin as well as a combination of thrombin/collagen to induce platelet activation and pEV generation. Proteomic profiling revealed that pEVs have an agonist‐dependent altered proteome in comparison to their cells of origin, activated platelets. Furthermore, we found that various protein classes including those related to coagulation and complement (prothrombin, antithrombin, and plasminogen) and platelet activation (fibrinogen) are attributed to platelet EVs following agonist stimulation. This agonist‐dependent altered proteome suggests that protein packaging is an active process that appears to occur without de novo protein synthesis. This study provides new information on the influence of physiological agonist stimuli on the biogenesis and proteome landscape of pEVs.
International disparities in diagnosis and treatment access for cystic fibrosis
Authors: Guo Jonathan , King Ibukunoluwa , Hill Andrew 
Published: April 2024

AbstractBackgroundElexacaftor/tezacaftor/ivacaftor (ETI) has revolutionized cystic fibrosis (CF) treatment. However, previous research has demonstrated profound global disparities in diagnosis and treatment access. If unaddressed, these threaten to widen existing health inequities. Therefore, in this analysis we aimed to reappraise gaps and evaluate progress in diagnosis and treatment equity in high‐income (HIC) versus low‐ and middle‐income countries (LMICs).MethodsEstimates of the global CF population were made in 158 countries using patient registries, systematic literature searches, and an international survey of 14 CF experts. Estimates of the global burden of undiagnosed CF were made using epidemiological studies identified in literature searches and registry coverage data. The proportion of people receiving ETI was estimated using publicly available revenue data and a survey of 23 national drug pricing databases.Results188,336 (163,421–209,204) people are estimated to have CF in 96 countries. Of these, 111,767 (59%) were diagnosed and 51,322 (27%) received ETI. The undiagnosed patient burden is estimated to be 76,569 people, with 82% in LMICs. ETI is reimbursed in 35 HICs, but only one LMIC. Four years after approval, there are 13,723 people diagnosed with CF who live in a country where ETI is inaccessible. This increases to 76,199 when including the estimated undiagnosed population.ConclusionsEquitable access to CFTR modulators must become a top priority for the international CF community. ETI costs up to $322,000 per year but could be manufactured for $5000 to allow access under a voluntary license. Given the extent of disparities, other mechanisms to improve access that circumvent the manufacturer should also be considered.
The Child Opportunity Index 2.0 and exacerbation‐prone asthma in a cohort of urban children
Authors: Skeen Emily H. , Moore Camille M. , Federico Monica J. , Seibold Max A. , Liu Andrew H. , Hamlington Katharine L. 
Published: April 2024

AbstractRationaleSocial determinants of health underlie disparities in asthma. However, the effects of individual determinants likely interact, so a summary metric may better capture their impact. The Child Opportunity Index 2.0 (COI) is one such tool, yet its association with exacerbation‐prone (EP) asthma is unknown.ObjectiveTo investigate the association between the COI and EP asthma and clinical measures of asthma severity in children.MethodsWe analyzed data from two prospective observational pediatric asthma cohorts (n = 193). Children were classified as EP (≥1 exacerbation in the past 12 months) or exacerbation‐null (no exacerbations in the past 5 years). Spirometry, exhaled nitric oxide, IgE, and Composite Asthma Severity Index (CASI) were obtained. The association between COI and EP status was assessed with logistic regression. We fit linear and logistic regression models to test the association between COI and each clinical measure.ResultsA 20‐point COI decrease conferred 40% higher odds of EP asthma (OR 1.4; 95%CI 1.1–1.76). The effect was similar when adjusted for age and sex (OR 1.38, 95%CI 1.1–1.75) but was attenuated with additional adjustment for race and ethnicity (OR 1.19, 95%CI 0.92–1.54). A similar effect was seen for the Social/Economic and Education COI domains but not the Health/Environment Domain. A 20‐point COI decrease was associated with an increase in CASI of 0.34. COI was not associated with other clinical measures.ConclusionsLower COI was associated with greater odds of EP asthma. This highlights the potential use of the COI to understand neighborhood‐level risk and identify community targets to reduce asthma disparities.
Construction of circular RNA‐based competing endogenous RNA network in colon cancer
Authors: Gu Zhengyu , Wu Weiyi , Lu Jinnan , Shen Jun 
Published: April 2024

AbstractCircular RNAs (CircRNAs) are now under discussion as novel promising biomarkers for patients with various tumors. Our study aimed to identify circRNAs related to the progression of colon cancer and to further investigate their roles in the development of colon cancer base on The Cancer Genome Atlas database. The competing endogenous RNA (ceRNA) network was constructed based on 4 circRNAs, 14 miRNAs, and 229 mRNAs. Meanwhile, three hub genes were identified via the protein protein interaction networks (PPI) network. It should be noted that only RUNX1 targeted by circ‐0084615 and mir‐330‐3p was confirmed as a survival‐related gene. Further analyses indicated the possible function of RUNX1 in colon progression, such as angiogenesis, epithelial–mesenchymal transition, hedgehog signaling and so on. Further investigations were conducted into the correlation between RUNX1 expression profiles and immune cells. Finally, we validated the expression of the circ‐0084615/mir‐330‐3p/RUNX1 axis in clinical specimens. In conclusion, we constructed ceRNA network and revealed that the circ‐0084615/mir‐330‐3p/RUNX1 axis serves as a critical role in colon cancer.
From strict socialism to social evils: Changing childhoods over three generations in urban Vietnam
Authors: Turner Sarah , Ngo Hanh Thuy , Nguyen Thao Dinh , Buttery Yvette 
Published: April 2024

AbstractOver the span of three generations, Vietnam's capital Hanoi, has transformed from a modest city grappling with food scarcity during the socialist subsidy era to a sprawling metropolis marked by gated communities and a widening wealth divide. Employing a child‐centric, multi‐generational family methodology, with members of 13 families across three generations, we explore the diverse childhood experiences shaped by these rapid urban transformations. Grandparents shared stories of unrestricted outdoor play despite challenging conditions, while parents noted a lack of academic pressures in their youth. Contemporary children enjoy access to new technology and consumer goods, but face important mobility restrictions due to parental and societal concerns. Our findings reveal that the Vietnamese context engendered distinctive childhood reflections for the two older generations, contrasting with childhoods in non‐socialist contexts during the same periods. Meanwhile, the contemporary Vietnamese state has crafted a ‘social evils’ discourse that shapes current childhood opportunities in specific ways. By being centered on urban Vietnam—a context vastly different from Global North‐dominated narratives in childhood studies—our study acts as a counterpoint that enriches the field with perspectives from a politically‐socialist state. Focusing on the unique childhood experiences within Hanoi's evolving socio‐spatial landscape, we advocate for more diverse understandings of childhood that respect varied realities across contexts.
Further complications to poverty of place: daily poverty dynamics across space
Authors: Mueller J. Tom , Heykmatpour Peyman , Brooks Matthew M. , Baker Regina S. 
Published: April 2024

AbstractIt is well established that living in a high‐poverty area often leads to lower levels of well‐being for residents. While these deleterious effects of place‐based poverty are well‐documented, the conceptual mechanisms linking poverty of place to negative outcomes remain debated, and the our understanding of the spatial patterning of poverty remains underdeveloped. In this paper, we problematize simple conceptualizations of the negative impacts of poverty exposure by illustrating the dynamic patterns poverty displays across cities on a daily basis. The vast majority of prior research on poverty of place has relied upon data anchored to place of residence. Thus, poverty rates broadly reflect poverty as it exists at night. This bias toward nighttime statistics leaves us with an incomplete understanding of spatial inequalities because daytime poverty rates can differ markedly from nighttime poverty rates due to work‐related commuting patterns. Here, we use novel data from the Census Transportation Planning Products to fully illustrate diurnal patterns in poverty at the census tract level in metropolitan America. Through a combination of descriptive, spatial, and statistical analyses, we show that the majority of census tracts experience changes in poverty throughout the day. Through a series of regression models, we also show that diurnal patterns in poverty are unevenly distributed along the lines of suburbanization, race, economic status, age composition, and industrial structure. Overall, our findings provide analytic insights into properly documenting poverty across space, while further problematizing lingering culture of poverty frameworks.
Intentions and abilities to migrate from Africa to Europe
Authors: Schöfberger Irene , Acostamadiedo Eduardo , Rango Marzia 
Published: April 2024

AbstractWhile migration from Africa to Europe is increasing, aspiring migrants from Africa are still less likely than those from other continents to migrate to their preferred destinations. An analysis of the reasons for this is needed. This paper investigates how individual‐level traits and country income levels influence intentions and abilities to migrate from Africa to Europe, while also exploring regional differences. It does so through an approach investigating the influence of both micro‐level factors and macro‐level factors, as well as their interactions. It first analyses migration intentions in 47 African countries in the Years 2010–2015, by investigating plans to migrate to Europe. It then analyses abilities to migrate from these countries to Europe in the Years 2011–2016, by exploring the proxy of the conversion of migration plans into flows. The analysis is based on Gallup World Poll, Eurostat, Organisation for Economic Co‐operation and Development, Frontex, and World Bank data and estimates. The paper finds that 1.4% of individuals in the African countries considered were planning to migrate to Europe in the Years 2010–2015, and an estimated 5.8% of these was able to migrate in 2011–2016. Migration intentions and abilities are shaped by a complex interplay of micro‐ and macro‐level factors. While some individual‐level traits have similar effects on migration intentions across country income levels, others increase the likelihood of planning to migrate to a stronger extent in countries of origin with higher income levels. Abilities to convert migration plans into actual migration, and to do so through regular channels, increase with higher country income levels. The influence of individual‐level traits and country income levels on migration intentions and abilities appears to vary across regions. Findings confirm the relevance of approaches investigating migration intentions and abilities by assessing both micro‐ and macro‐level factors, as well as their interactions. A more nuanced understanding of these interactions is crucial to inform migration policies that recognise the different needs and realities of aspiring migrants.