bluuebunny/crossref_metadata_2025_split huggingface dataset:
Value of retroperitoneal lymph node dissection in advanced testicular seminoma
Authors: Kamat Murali R. , Kulkarni Jagdeesh N. , Tongaonkar Hemant B. , Ravi R. 
Published: February 2007

AbstractSeven patients with advanced seminoma of the testis (stages II C and III) were treated with 3 induction cycles of VAB‐6 chemotherapy. Three patients had complete remission after chemotherapy and are alive disease free at 32, 38, and 40 months with no additional treatment. Four patients were subjected to retroperitoneal lymph node dissection for residual retro‐peritoneal masses measuring 2–4 cm after chemotherapy, which revealed fibrosis in 2 patients and metastatic seminoma in the other 2. Patients with metastatic residual masses were given postoperative radiation therapy to the retroperitoneum and are alive disease free at 33 and 34 months, while those with fibrosis are alive disease free at 30 and 52 months, respectively, with no additional treatment. © 1992 Wiley‐Liss, Inc.
A 94 year old male stage IV breast cancer patient showing complete remission under tamoxifen treatment after operation
Authors: Tateishi Masahiro , Toda Tomohiro , Minamisono Yoshikazu , Nagasaki Susumu , Sugimachi Keizo 
Published: February 2007

AbstractA 94 year old man with an invasive ductal carcinoma of the breast (T4N2M1, stage IV), underwent a modified radical mastectomy to improve his quality of life. The estrogen receptor status of both the breast tumor and the metastatic axillar lymph nodes was high. Immunohis‐tochemical staining for epidermal growth factor, epidermal growth factor receptor, or c‐erbB‐2 protein was negative. The patient received only tamoxifen continuously for 3 months, and later apparently showed a complete remission. Therefore, in advanced male breast cancer with a high estrogen receptor status, operation in conjunction with hormone therapy may lead to a favorable result in some cases. © 1992 Wiley‐Liss, Inc.
Poorly differentiated solid type adenocarcinomas in the stomach: A clinicopathologic study of 71 cases
Authors: Ueyama Toshihiko , Tsuneyoshi Masazumi , Meyer John S 
Published: February 2007

AbstractA review of 71 cases of solid carcinoma of the stomach selected from 2,738 cases of surgically resected poorly differentiated adenocarcinomas (PDAs) was undertaken. The average age of the patients, which included 47 men and 24 women, was 62 years. The clinicopathologic features of solid carcinomas were similar to those of the differentiated type adenocarcinomas. The solid carcinomas were divided into 42 of the solid alveolar type and 29 of the free‐cell type; 32 of the former (76%) had foci of overt differentiated areas, while most of the latter type lacked such foci and had some signet‐ring cells. Many tumors of both types had a prominent venous permeation and lymph node metastasis even in the early stage of invasion. The 5‐year survival rates were 37% in all cases, 44% in cases with carcinoma with a limited invasion of the submucosa or the muscularis propria, and 27% in carcinoma invading down to the subserosa. These survival rates were poor in comparison with the 110 cases of ordinary PDA (diffuse type of Lauren) selected as controls. These findings suggest that tumors of the solid alveolar type are transformed from the differentiated type of adenocarcinoma, while those of the free‐cell type are originally from PDAs. It is also suggested that solid carcinomas did show a high incidence of venous permeation and lymph node metastasis and that the prognosis for this type of carcinoma is poor. © 1992 Wiley‐Liss, Inc.
Cisplatin‐based (PVB+M) chemotherapy in good‐risk and poor‐risk nonseminomatous germ cell tumors
Authors: Saikia Tapan , Hegde Upendra , Advani Suresh , Ramakrishnan Gopal , Kulkarni Jagdeesh , Desai Prafulla B. 
Published: February 2007

AbstractTwenty‐seven patients with metastatic nonseminomatous germ cell tumors were treated with Cisplatin, vinblastine, bleomycin, and low‐dose meth‐otrexate (PVB + M) combinations. Patients were divided into good‐risk and poor‐risk groups. All seven patients (100%) with good‐risk factors achieved complete response, and all are alive disease free at a median of 70 months. In the poor‐risk group, only 10 of 20 patients (50%) achieved complete response, and seven (35%) are alive disease free at a median of 58 months. Eight patients, 4 in each group, were required to undergo surgery for removal of postchemotherapy residual masses. The results confirm that Cisplatin‐based chemotherapy protocols are adequate to cure most patients with good‐risk factors, and newer approaches are needed for patients at poor risk. © 1992 Wiley‐Liss, Inc.
Skeletal metastasis from occult carcinoma
Authors: Shih Lih‐Yuann , Chen Tien‐Hsiung , Lo Wai‐Hee 
Published: February 2007

AbstractWe reviewed 177 patients with skeletal metastases, seen between 1984 and 1989, to define the characteristics of metastatic bone disease from an occult primary carcinoma. In 52 (30%) patients, the primary carcinomas could not be identified when the bone metastases were first diagnosed. This group was predominantly male, with intractable pain the most common symptom. The primary tumors were identified on antemortem evaluation in 28 (54%) patients after extensive examination. Among these, the primary tumor was in the lung in 9 patients, followed by liver (8), kidney (5), prostate (3), thyroid gland (2), and rectum (1). The identifiable occult malignancies possessed three common features: all were osteophilic tumors, all had a high incidence in the specific geographic area, and all were not amenable to early detection. The mean survival of these patients was 11 months. Current treatment modalities failed to affect the course of these patients, except for those with primary carcinomas of the kidney and prostate. This observation attests to our limitations in both the diagnosis and treatment of this problem. Efforts should be directed primarily toward excluding those common and/or treatable tumors only. © 1992 Wiley‐Liss, Inc.
Early gastric cancer: An analysis of 44 cases with emphasis on the prognostic significance of the macroscopic and microscopic growth patterns
Authors: Oliveira Pedro , Nobre‐Leitão C. , Chaves Paula 
Published: February 2007

AbstractForty‐four consecutive cases of “early gastric cancer” were studied according to the macroscopic classification proposed by the Japanese Gastroenterological and Endoscopy Society and further analyzed in terms of growth patterns. The tumours were then classified into the small mucosal type, the superficially spreading (Super) type and the penetrating growth (Pen) type. The Lauren type (intestinal vs. diffuse), presence of lymphatic and venous invasion, and lymph node metastasis were also assessed. Most elevated tumours showed a superficial growth pattern and were classified as Lauren's intestinal type, whereas depressed lesions were associated with submucosal invasion and were classified as diffuse. Microscopic patterns did not show any correlation with Lauren's classification. Mean duration of follow‐up was 67.8 months and the overall actuarial survival was 93%, 80%, and 72%, at 2, 5, and 10 years, respectively. Aside from venous invasion no correlation was found between survival and any of the morphological parameters analysed. © 1992 Wiley‐Liss, Inc.
Therapeutic gain of local and radical resection combined with postoperative radiation for murine fibrosarcomas
Authors: Todoroki Takeshi , Suit Herman D. , Karakousis Constantine P. 
Published: February 2007

AbstractResection of 8‐mm fibrosarcomas (FSaII) growing in the right leg of syngeneic C3H/Sed mice was performed under a dissecting (×8) microscope. Local and radical resection achieved 20% (5/25) and 48% (12/25) tumor control, respectively. TCD80s (average dose expected to control 80% of irradiated tumors) for radiation alone given as one fraction per day for 5 consecutive days were 73.1 and 118.0 Gy for the microscopic and 8‐mm tumors, respectively. Radiation therapy started at 4 or 7 days following local or radical resection enhanced both the local tumor control and the treatment‐related morbidity represented by leg shortening. From enhancement ratios (ERs) for tumor control (TCD80 for radiation alone/TCD80 for postoperative radiation) and for leg shortening (dose for 5‐mm leg shortening for radiation alone/postoperative radiation) values, therapeutic gain factors (TGFs) were derived as ER tumor/ER leg shortening. These were 1.3 and 1.4 for local and radical resection followed by radiation started on the 7th postoperative day, respectively. Corresponding figures for radiation started on the 4th postoperative day resulted in 1.2 for both resection procedures. © 1992 Wiley‐Liss, Inc.
The changing role of the surgeon in the management of cancer in the university setting and its impact on resident training
Authors: Sariego Joaquin , Byrd Michael , Matsumoto Teruo , Kerstein Morris 
Published: February 2007

AbstractA retrospective review was performed of 22,168 cancer cases registered by the Tumor Registry between 1965 and 1990. Eighty‐six percent of these cases involved solid tumors; this number remained fairly constant throughout the study period. There was a significant trend toward more advanced disease at the time of presentation, most marked in the last 10 years; prior to 1980, 63.7% had localized or in situ cancer as opposed to only 49.4% since 1980 (P<0.001). This suggested that more advanced cases were being submitted for treatment. As expected, more disseminated disease at the time of presentation was coupled with an overall decrease in the number of cases in which surgery comprised part of the treatment: 43.6% prior to 1980 vs. 38.1% after 1980. This trend has reversed, however, in the last 5 years. Though the number of cases in which surgery was the only treatment modality remained constant prior to and after 1985 (26.8% and 27.1%, respectively), the number of cases in which surgery was part of a multimodality treatment plan significantly increased (39.9% prior to 1985; 45.3% after 1985). This was coupled with a significant decrease in the number of cases treated with nonsurgical modalities alone (60.1% prior to 1985; 54.7% after 1985). Therefore,not only has the surgeon been called upon to operate on more advanced disease for cure in the last 5 years, but he or she has also become increasingly involved in multimodality treatment. Since 40.4% of university departments of surgery (as of 1990) did not provide specific training in surgical oncology, it is suggested that these departments reevaluate the objectives of their educational programs in view of the changing, increasingly complex role of the surgeon in the multidisciplinary approach to the care of the cancer patient. © 1992 Wiley‐Liss, Inc.
Impaired neutrophil bactericidal activity correlates with the infection occurring after surgery for esophageal cancer
Authors: Saito Takao , Shigemitsu Yuji , Kinoshita Tadahiko , Katsuta Takeshi , Shimoda Katsuhiro , Miyahara Masaki , Kobayashi Michio 
Published: February 2007

AbstractWe examined whether or not preoperative impaired bactericidal activities of polymorphonuclear neutrophils (PMN) are associated with infections following surgery for esophageal cancer. Intracellular killing (KI), superoxide anion‐producing capacity (SOP), and myeloperoxidase (MPO) activity were measured in 22 patients with esophageal cancer, 27 with gastric cancer, and 13 age‐matched controls. The average level of KI was significantly depressed in patients with esophageal cancer or with gastric cancer, to a similar extent, compared to findings in controls, but SOP was not. In esophageal cancer patients, the SOP level was significantly higher in those with postoperative septic complications than in those without such problems, whereas the KI level was depressed to a similar extent in both. Therefore, a depression of KI with elevation of SOP of PMN may serve to predict complications of infection following surgery in patients with esophageal cancer. © 1992 Wiley‐Liss, Inc.
Breast masses in adolescent females
Authors: Siegal Annette , Kaufman Zvi , Siegal Gil 
Published: February 2007

AbstractIn a retrospective study of 38 adolescent females operated on for mammary masses, 42 fibroadenomata (FA), 2 fibrous scars around abscesses, and one papilloma were found. All were postmenarchal. Clinical and pathological features were reviewed and the patients reexamined or interviewed. FA were mostly asymptomatic and removed a few weeks after incidental discovery. They were often seen in Jewish girls of parents born in North Africa and the Middle East, and were more frequently located in the outer superior quadrant of the left breast. New FA appeared in almost half of the cases later on in the same breast, as well as in the other breast, or bilaterally. Necrosis occurred in three FA and was unrelated to the size of the tumor. There was no correlation between the size of FA, multiplicity, or necrosis, nor between increased stromal or epithelial atypia, cellularity, or mitotic activity. One explanation for the high rate of multiplicity might be related to this neoplasm occurring in an actively developing organ under hormonal control. There was no increased breast carcinoma apparent in the family history. Therefore, except in cases of fast‐growing tumors, a conservative approach is recommended because of the frequency of multiple FA as well as aesthetical postoperative complications. © 1992 Wiley‐Liss, Inc.
Noncurative resection for advanced gastric cancer
Authors: Maehara Yoshihiko , Kakeji Yoshihiro , Takahashi Ikuo , Okuyama Toshiro , Baba Hideo , Anai Hideaki , Sugimachi Keizo 
Published: February 2007

AbstractBetween 1965 and 1985, 489 patients with advanced gastric cancer who were treated with gastric resection and in whom tumor cells remained after the operation were defined as cases of a “noncurative resection.” The clinicopathological features and prognosis of these patients were examined and two groups were prepared: locally advanced cancer and cancer with a distant metastasis. In locally advanced cancer cases, tumor cells remained in the neighboring organs, lymph nodes, and/or resected margins; in those with distant metastasis, peritoneal dissemination and/or liver metastasis were present regardless of whether or not the metastasis was removed, with or without locally noncurative factors. Serosal invasion was prominent and high rates of lymph node metastasis and lymphatic inolvement were evident in both groups. The survival rate for patients with locally advanced gastric cancer was better than that of patients with distant metastasis (P < 0.01). Survival time in patients with locally advanced cancer can be lengthened by resecting all of the primary tumor and as much of the metastatic lesions as possible, even if the surgical management is “noncurative.” Aggressive postoperative chemotherapy for patients with distant metastasis from a gastric cancer is to be recommended. © 1992 Wiley‐Liss, Inc.
Chromosome aberrations of human small cell lung cancer induced by a new 111in‐bleomycin complex
Authors: Hou De‐Yan , Maruyama Yosh , Drago Joseph R. 
Published: February 2007

AbstractA new 111Indium labeled bleomycin complex (111In‐BLMC) was prepared and found to be effective for tumor imaging and therapy both in mouse glioma and human small cell lung cancer (SCLC) cells. Chromosome aberrations were studied in human SCLC cells to explore its mechanisms of killing cancer cells. SCLC cells (N417) were exposed to 111In‐BLMC, BLM, or 111InCl3 (for control) for 1 hour, treated with colcemid, and chromosomal changes were analyzed. A dramatic increase in chromatic gaps, breaks, chromosome breaks, double minutes, rings, triradii, quadriradii, and chromosome stickiness were observed in the cells treated by 111In‐BLMC compared to BLM or 111InCl3. These results indicated that 111In‐BLMC has therapeutic potential for combination chemo‐radiotherapy of cancer (e.g., by Auger electrons and local energy deposition). © 1992 Wiley‐Liss, Inc.
Antitumor effect of triphenylethylene derivative (TAT‐59) against human breast carcinoma xenografts in nude mice
Authors: Koh Jun‐Ichi , Kubota Tetsuro , Asanuma Fumiki , Yamada Yoshinori , Kawamura Eiji , Hosoda Yoichiro , Hashimoto Mitsumasa , Yamamoto Osami , Sakai Shoji , Maeda Koutaro , Shiina Eiichi 
Published: February 2007

AbstractThe antitumor activity of a newly synthesized triphenylethylene derivative {(E)‐4‐[1‐4‐[2‐(dimethylamino)ethoxy‐phenyl]‐2‐(4‐isopropyl)phenyl‐1‐butenyl] phenyl monophosphate} (TAT‐59) was investigated against human breast carcinoma xenografts in nude mice with reference to the changes of hormone receptors. Five strains (MCF‐7, Br‐10, R‐27, ZR‐75–1, and T‐61) used for the experiments possessed cytosol estrogen receptor (ER), and their growth was estradiol dependent. Five mg of TAT‐59 and tamoxifen citrate (TAM) per kg were administered p.o. daily except Sunday. TAT‐59 showed a positive antitumor effect against MCF‐7 and R‐27, whereas TAM was effective on MCF‐7, and their adverse effects detected by mortality rate, body weight loss, and spleen weight loss were similar to each other. The reduction of ER and production of progesterone receptor (PgR) after the treatment with TAT‐59 were more potent than after TAM, suggesting that TAT‐59 exerts its antitumor effect through binding to ER. These findings suggest that TAT‐59 might merit use in clinical trials with breast cancers. © 1992 Wiley‐Liss, Inc.
Primary gastrointestinal lymphomas in Turkey: A retrospective analysis of clinical features and results of treatment
Authors: Dinçol Dilek , Içi Fikri , Erekul Selim , Günel Nazan , Karaoǧuz Handan , Demirkazik Ahmet 
Published: February 2007

AbstractThirty‐three patients with primary gastrointestinal lymphoma (GIL) followed at Ankara University Medical School have been evaluated. The most frequent locations of the disease are the small intestine (48.4%) and the stomach (39.3%). The intermediate and high grade lymphomas constitute 84.8% of the cases. The mean age of the patients with small intestinal lymphoma is 28.7 years and 47.1 years for those with gastric lymphoma. The patients treated with surgery and chemotherapy (S + CT) have a longer survival than those treated with chemotherapy (CT) alone. In conclusion: 1) Small intestinal lymphoma occurs more frequently than gastric lymphoma in our study. 2) The median age of the Turkish patients with primary GIL is approximately 10 years less than those in the Western countries. 3) The therapeutic results of S + CT are superior to those of CT in the early stages of the disease. © 1992 Wiley‐Liss, Inc.
Cervical exploration for primary hyperparathyroidism
Authors: Shaha Ashok R. , Jaffe Bernard M. 
Published: February 2007

AbstractThe classical presentation of primary hyperparathyroidism, “moans, bones, groans,” is no longer commonly seen since the diagnosis of hypercalcemia is now made much earlier with the routine use of the SMA 12. In the past 8 1/2 years, 85 patients underwent cervical exploration in our institution for primary hyperparathyroidism. There were 34 male and 51 female patients, ranging in age from 18–84 years. The specific symptoms included hypertension in 40 patients, generalized weakness in 25, renal stones in 14, psychiatric problems in 2, and bone changes on X‐ray in 4. Forty‐one patients were totally asymptomatic. The diagnosis was made mainly on the basis of history, serum calcium and phosphorous levels, parathormone assay, and 24‐hour urinary calcium studies. Preoperative localization studies were performed in 38 patients. Thallium technetium subtraction scans, when positive, were very helpful. The surgical approach involved stepwise exploration of both sides of the neck with identification of all four parathyroid glands. In patients with uniglandular pathology (87%), the adenoma was removed with biopsy of at least one normal gland. In multiglandular disease, the abnormal glands were removed. Frozen section was routinely performed to confirm the presence of parathyroid tissue and no attempt was made to pathologically distinguish adenoma from hyperplasia. Two patients had parathyroid carcinoma. In three patients, serum calcium levels did not fall, resulting in an operative success rate of 96%. One patient treated by subtotal parathyroidectomy developed permanent hypoparathyroidism and one other patient developed temporary hypocalcemia. Only a single patient developed vocal cord palsy. Early exploration in patients with primary hyperparathyroidism is indicated. The basic diagnostic workup is sufficient for initial exploration. It is important to distinguish uniglandular from multiglandular pathology after careful bilateral exploration and identification of all four parathyroid glands. © 1993 Wiley‐Liss, Inc.
Composite reconstruction of the esophagus
Authors: Omura Kenji , Misaki Takuro , Urayama Hiroshi , Ishida Fumio , Watanabe Yoh 
Published: February 2007

AbstractComposite reconstruction of the esophagus using both the mobilized stomach and free jejunal graft is described. Tension at the anastomotic site can be minimized with interposition of a jejunal autograft between the pharyngeal stump and the mobilized stomach, even when the mobilized stomach is not long enough. Furthermore, problems derived from differing calibers of the pharyngeal stump and the mobilized stomach can be resolved by creating an end‐to‐side pharyngojejunal anastomosis. Our method is proposed as one procedure for reconstruction of the esophagus when the pull‐up organ is too short. © 1993 Wiley‐Liss, Inc.
Risk of internal mammary lymph node metastases and its prognostic value in breast cancer patients
Authors: Noguchi Masakuni , Ohta Nagayoshi , Thomas Michael , Kitagawa Hirohisa , Miyazaki Itsuo 
Published: February 2007

AbstractThe risk of an internal mammary lymph node (IMN) metastasis and its prognostic value for patients with invasive breast cancer were assessed by evaluating 142 patients who had either a mastectomy with lymph node dissection or a biopsy of the IMN. By univariate analysis, overall survival significantly correlated with the patient's age, clinical axillary node status, tumor size, and DNA ploidy, as well as histologically confirmed axillary and IMN metastases. By multivariate analysis, however, only the presence of axillary and IMN metastases appeared to be an important independent factor affecting survival. However, the incidence of IMN metastases was associated significantly with age, clinical tumor and axillary node status, tumor size, axillary lymph node metastases, and DNA ploidy. Accordingly, the patient's age, tumor size, DNA ploidy, and axillary lymph node metastases proved to be effective variable for discrimination. Consequently, in predicting the presence of IMN metastases, a diagnostic accuracy of 82%, a sensitivity of 84%, and a specificity of 82% can be achieved by a discriminant function. We conclude that the discriminant function with these four variables is effective in assessing the risk of IMN metastases. © 1993 Wiley‐Liss, Inc.
Surgical treatment of esophageal carcinoma in patients eighty years of age and older
Authors: Kuwano Hiroyuki , Morita Masaru , Baba Kinya , Kitamura Kaoru , Toh Yasushi , Matsuda Hiroyuki , Sugimachi Keizo 
Published: February 2007

AbstractBefore 1979, no patient 80 years of age or older had been operated on at our institution for esophageal cancer, while in the middle period (1980–1984), three patients were operated on, and postoperative pulmonary complications and operative death occurred in 66.7 and 33.3%, respectively. However, in the recent period (1985–1990), there was no postoperative morbidity or mortality in the five cases over age 80. On the other hand, there were 12 patients over age 80 who did not undergo operation, of whom all died of cancer. In the eight operated patients over age 80, two cases are still alive 17 and 34 months after operation. According to the above findings, when the patient's general condition is evaluated to be sufficient to tolerate the operation and the cancer is judged to be resectable, esophageal resection is thought to be indicative in all patients over eighty. © 1993 Wiley‐Liss, Inc.