bluuebunny/crossref_metadata_2025_split huggingface dataset:
The emperor's new glass: The introduction of Carolingian wood ash glass in North Sea trade
Authors: Barfod Gry H. , Feveile Lene L. , Sindbæk Søren M. 
Published: April 2024

AbstractMicro‐X‐ray fluorescence (XRF) screening of 244 glass sherds from Ribe, Denmark, identified 23 wood ash glasses. The closely dated finds pinpoint the arrival of the earliest wood ash glass produced in Western Europe in this important North Sea trading hub. This glass type was absent among glass from 700 to 790 CE but feature strongly from 790 to 810 CE. Electron microprobe analysis (EMPA) and laser ablation inductively coupled plasma mass spectrometry (LA‐ICP‐MS) analysis of 24 glasses show the presence of four types. We show the strengths of classifying wood ash glass based on the glass‐producing sands and conclude that the earliest production took place on a considerable scale and had a major impact on glass circulation in Northern Europe in the ninth century.
Mobilizing ideas of order: Burden‐sharing in the US–Japan and ANZUS alliances
Authors: Dell'Era Alice , Martín Félix E. 
Published: April 2024

AbstractDebates on allies' contributions to alliances focus mainly on the material dimension. Accordingly, smaller partners are often belittled for failing to contribute their fair share to their defensive alliances with more powerful allies. While acknowledging that junior partners’ contributions do not match the same level of material capabilities provided by a more significant power like the United States, this study highlights the importance of other intangible contributions. We argue that defensive alliances during peacetime require a crucial, albeit overlooked, ideational contribution by all allies. We examine the US–Japan and ANZUS alliances to explore the process through which junior partners advance the interests of an alliance through ideational contributions. Our findings reveal that Japan and Australia contribute to their respective alliances with the United States by mobilizing fundamental ideas and norms that sustain and promote a specific global order and security vision. We maintain that such intangible contributions are necessary for alliance success.
Exploring the interplay: Maternal electronic health literacy and its impact on early childhood development and parenting practices
Authors: Oflu Ayse , Yalcin Siddika Songul 
Published: April 2024

AbstractBackgroundMothers need a competent electronic health literacy (eHL) skill for beneficial gains for the health of their children in the virtual environment, which is a new health platform. We predict that a competent eHL of mothers who play a central role in early childhood will positively affect the health of their children. This study aimed to determine the level of eHL of mothers of young children and investigate the relationship between mothers' eHL and early childhood development (ECD) and early parenting practices (EPP).MethodsThis cross‐sectional study was conducted on mothers with children aged 36–59 months using eHealth. Sociodemographic and personal characteristics form, Early Childhood Development Module and eHealth Literacy Scale were administered to the participating mothers.ResultsThe data from 440 mother–child pairs were analysed. Children of mothers with sufficient eHL levels were more likely to be Early Childhood Development Index (ECDI)‐on‐track, adjusted odds ratio (AOR), 95% confidence interval (CI): 2.16 (1.29–3.61); have adequate support in learning, AOR (%95 CI): 3.23 (1.69–6.18); and have adequate daily meals and snacks, AOR (%95 CI): 2.43 (1.56–3.78).ConclusionThese results revealed that there is a need for interventions that will contribute to child health by improving mothers' eHL levels.
Radiotherapy and stereotactic radiotherapy for multifocal intracranial and intramedullary Rosai–Dorfman disease
Authors: D'Oria Salvatore , Rossitto Martina , Giraldi David , Fanelli Vincenzo , Bonaparte Ilaria , Ciliberti Maria Paola , Fiorentino Alba 
Published: April 2024

AbstractBackgroundWe present a case of a 51‐year‐old man affected by Rosai–Dorfman disease with multiple disseminated intraparenchymal and a single spinal cord localization, presenting with dysphasia and paraparesis.Case PresentationThe patient elected to receive medical steroidal therapy and two radiotherapy cycles. Steroids allowed initial regression of some lesions, while radiotherapy constituted an optimal maintenance treatment. At 6‐year follow up, the patient did not develop any new neurological damage in respect to baseline.ConclusionsAdjuvant therapy with radiotherapy and steroidal therapy is a valid option in multicentric Rosai–Dorfman disease patients not eligible for surgery.
Hippocampal sclerosis and temporal lobe epilepsy following febrile status epilepticus: The FEBSTAT study
Authors: Lewis Darrell V. , Voyvodic James , Shinnar Shlomo , Chan Stephen , Bello Jacqueline A. , Moshé Solomon L. , Nordli Douglas R. , Frank L. Matthew , Pellock John M. , Hesdorffer Dale C. , Xu Yuan , Shinnar Ruth C. , Seinfeld Syndi , Epstein Leon G. , Masur David , Gallentine William , Weiss Erica , Deng Xiaoyan , Sun Shumei ,   the FEBSTAT Study Team
Published: April 2024

AbstractObjectiveThis study was undertaken to determine whether hippocampal T2 hyperintensity predicts sequelae of febrile status epilepticus, including hippocampal atrophy, sclerosis, and mesial temporal lobe epilepsy.MethodsAcute magnetic resonance imaging (MRI) was obtained within a mean of 4.4 (SD = 5.5, median = 2.0) days after febrile status on >200 infants with follow‐up MRI at approximately 1, 5, and 10 years. Hippocampal size, morphology, and T2 signal intensity were scored visually by neuroradiologists blinded to clinical details. Hippocampal volumetry provided quantitative measurement. Upon the occurrence of two or more unprovoked seizures, subjects were reassessed for epilepsy. Hippocampal volumes were normalized using total brain volumes.ResultsFourteen of 22 subjects with acute hippocampal T2 hyperintensity returned for follow‐up MRI, and 10 developed definite hippocampal sclerosis, which persisted through the 10‐year follow‐up. Hippocampi appearing normal initially remained normal on visual inspection. However, in subjects with normal‐appearing hippocampi, volumetrics indicated that male, but not female, hippocampi were smaller than controls, but increasing hippocampal asymmetry was not seen following febrile status. Forty‐four subjects developed epilepsy; six developed mesial temporal lobe epilepsy and, of the six, two had definite, two had equivocal, and two had no hippocampal sclerosis. Only one subject developed mesial temporal epilepsy without initial hyperintensity, and that subject had hippocampal malrotation. Ten‐year cumulative incidence of all types of epilepsy, including mesial temporal epilepsy, was highest in subjects with initial T2 hyperintensity and lowest in those with normal signal and no other brain abnormalities.SignificanceHippocampal T2 hyperintensity following febrile status epilepticus predicted hippocampal sclerosis and significant likelihood of mesial temporal lobe epilepsy. Normal hippocampal appearance in the acute postictal MRI was followed by maintained normal appearance, symmetric growth, and lower risk of epilepsy. Volumetric measurement detected mildly decreased hippocampal volume in males with febrile status.
Genetic load and viability of a future restored northern white rhino population
Authors: Wilder Aryn P. , Steiner Cynthia C. , Hendricks Sarah , Haller Benjamin C. , Kim Chang , Korody Marisa L. , Ryder Oliver A. 
Published: April 2024

AbstractAs biodiversity loss outpaces recovery, conservationists are increasingly turning to novel tools for preventing extinction, including cloning and in vitro gametogenesis of biobanked cells. However, restoration of populations can be hindered by low genetic diversity and deleterious genetic load. The persistence of the northern white rhino (Ceratotherium simum cottoni) now depends on the cryopreserved cells of 12 individuals. These banked genomes have higher genetic diversity than southern white rhinos (C. s. simum), a sister subspecies that successfully recovered from a severe bottleneck, but the potential impact of genetic load is unknown. We estimated how demographic history has shaped genome‐wide genetic load in nine northern and 13 southern white rhinos. The bottleneck left southern white rhinos with more fixed and homozygous deleterious alleles and longer runs of homozygosity, whereas northern white rhinos retained more deleterious alleles masked in heterozygosity. To gauge the impact of genetic load on the fitness of a northern white rhino population restored from biobanked cells, we simulated recovery using fitness of southern white rhinos as a benchmark for a viable population. Unlike traditional restoration, cell‐derived founders can be reintroduced in subsequent generations to boost lost genetic diversity and relieve inbreeding. In simulations with repeated reintroduction of founders into a restored population, the fitness cost of genetic load remained lower than that borne by southern white rhinos. Without reintroductions, rapid growth of the restored population (>20–30% per generation) would be needed to maintain comparable fitness. Our results suggest that inbreeding depression from genetic load is not necessarily a barrier to recovery of the northern white rhino and demonstrate how restoration from biobanked cells relieves some constraints of conventional restoration from a limited founder pool. Established conservation methods that protect healthy populations will remain paramount, but emerging technologies hold promise to bolster these tools to combat the extinction crisis.
Atlanto‐occipital fracture: Intrathecal corticosteroid medication of the subarachnoid space—A novel treatment method
Authors: Hall Suzy , Meehan‐Howard Lucy , Prutton Jamie 
Published: April 2024

SummaryThis case report describes the successful conservative management of a comminuted fracture of the atlas and occiput involving the atlanto‐occipital joint. To the authors' knowledge, treatment of fractures involving the atlanto‐occipital joint in the horse and intrathecal subarachnoid space corticosteroid injection in the standing sedated patient has not been previously reported. Clinical signs following atlanto‐occipital (AO) fracture included acute onset ataxia, proprioceptive deficits and neck stiffness; which developed immediately post‐trauma during head and tail rope‐assisted recovery from general anaesthesia. Radiographic examination was not diagnostic immediately post‐trauma and computed tomography (CT) imaging subsequently identified articular fractures of the atlas and occiput. Treatment included ultrasound‐guided intrathecal medication of the subarachnoid space and intra‐articular medication of the left AO joint under standing sedation. Medication resulted in a marked improvement in clinical signs (grade 4 ataxia to grade 1 ataxia) and a return to ridden exercise 12 months post‐injury.
Climbing mechanisms as a central trait to understand the ecology of lianas across the tropics
Authors: Dias Arildo S. , Oliveira Rafael S. , Martins Fernando R. , Bongers Frans , Anten Niels P. R. , Sterck Frank J. 
Published: April 2024

AbstractAimsLianas are a central component of tropical forests. However, how the type of climbing mechanisms is related to the functional and taxonomic diversity of lianas across the tropics, remains largely unresolved. Here, we tested two main hypotheses: (i) the functional diversity of lianas differs with climbing mechanism (active and passive) and (ii) the association between taxonomic diversity with contemporary climate, paleoclimate, forest structure and phylogeny differ between climbing mechanisms.LocationTropical forests.Time PeriodPresent.Major Taxa StudiedTerrestrial plants.MethodsWe assembled functional traits and the type of climbing mechanism for 702 liana species and used the World Checklist of Vascular Plants (WCVP v.2.0) to standardize species names, map geographical distribution and estimate taxonomic richness. We used kernel density n‐dimensional hypervolume to estimate the functional diversity of each type of climbing mechanism. We compared the environmental response of taxonomic richness of each type of climbing mechanism, active and passive, to the response of overall liana species richness. We assessed the magnitude and direction of the environmental response considering variables of climate, soil fertility and forest structure.ResultsWe found that active climbing exhibits a higher functional richness than passive climbing. Richness patterns of active and passive climbing mechanisms were mainly driven by contemporary climate, paleoclimate and phylogenetic relatedness. More importantly, paleoclimate was negatively associated with active climbing and positively associated with passive climbing.Main ConclusionsOur study highlights differences in functional diversity (richness, dispersion, evenness and originality) between active and passive climbing species, likely reflecting their distinct ecological strategies for resource use, stress tolerance and dispersal. Integrating taxonomic and functional diversity metrics with information about the type of climbing mechanism provides deeper insights into the ecology and response of lianas to climate change.
The imagined island: Colonialism and constructed remoteness on Diego Garcia
Authors: Motluk Kate 
Published: April 2024

AbstractColonial powers have long used islands and island forms for imperial projects, including military bases, weapons testing, resource mining and migrant detention. In order to pursue these interests, colonial powers have often sought geographically remote sites, but they further rely on the construction of remoteness. This article reflects on the colonial construction of remoteness by analysing the case study of Diego Garcia. The militarised atoll of Diego Garcia is one in a chain of islands that make up the British Indian Ocean Territory, the last colony created by the British government. While Diego Garcia is now under British sovereign control, the island was brutally cleared of its Indigenous inhabitants to make way for a joint British‐American military base. By detailing the ways in which ‘remoteness’ has affected the Indigenous Chagossians, ‘war on terror’ detainees, asylum‐seekers and migrant workers, this article demonstrates how colonial powers deploy remoteness as a way of distancing groups deemed ‘other’ from rights. Additionally, colonial powers use ‘remoteness’ to paradoxically protect their own proximity to colonial interests, including geopolitically significant sites for military installations.
Regional development policy in Galilee periphery in Israel
Authors: Arie Herscovici , Osnat Akirav 
Published: April 2024

AbstractIn Israel, regional clusters serve as a mechanism for regional development, achieved through the integration of interests, pooling of resources, knowledge transfer, and the facilitation of agglomerations. This study gains insights from two EU regional development programs, LEADER and URBACT, to potentially benefit the regional clusters in Galilee, Israel's northern periphery. The research examined five municipal clusters in Galilee, aiming to identify their distinct characteristics and place them within a wider theoretical and comparative framework. A qualitative research approach was adopted, involving semi‐structured interviews with the clusters' CEOs and an analysis of pertinent policy documents. The findings suggest that Galilee's municipal clusters encounter challenges similar to those faced by the EU's LEADER and URBACT programs. These include establishing regional networks, achieving recognition for their capabilities, and cultivating trust and cooperation gradually. The CEOs shared their experiences in navigating the challenges posed by wary mayors and government ministries. The recognized success of these clusters, as evidenced in policy documents, could signify a shift from Israel's traditional centralist political culture to a more decentralized power structure.
Considerable interlaboratory variation in PD‐L1 positivity for head and neck squamous cell carcinoma in the Netherlands— A nationwide evaluation study
Authors: Hempenius Maaike Anna , Koomen Bregje M , Deckers Ivette A G , Oosting Sjoukje F , Willems Stefan M , van der Vegt Bert 
Published: April 2024

AimsPatients with recurrent or metastatic head and neck squamous cell carcinoma (HNSCC) are eligible for first‐line immune checkpoint inhibition if their tumour is positive for programmed death ligand 1 (PD‐L1) determined by the combined positive score (CPS). This nationwide study, using real‐world data, investigated the developing PD‐L1 testing landscape in the first 3 years after introduction of the test in HNSCC and examined interlaboratory variation in PD‐L1 positivity rates.MethodsPathology reports of HNSCC patients mentioning PD‐L1 were extracted from the Dutch Pathology Registry (Palga). Tumour and PD‐L1 testing characteristics were analysed per year and interlaboratory variation in PD‐L1 positivity rates was assessed using funnel plots with 95% confidence limits around the overall mean.ResultsA total of 817 PD‐L1 tests were reported in 702 patients among 19 laboratories; 85.2% of the tests on histological material were stated to be positive. The national PD‐L1 positivity rate differed significantly per year during the study period (79.7–89.9%). The use of the recommended 22C3 antibody increased from 59.9 to 74.3%. A total of 673 PD‐L1 tests on histological material from 12 laboratories were analysed to investigate interlaboratory variation. Four (33%) deviated significantly from the national mean of PD‐L1‐positive cases using CPS ≥ 1 cut‐off, while two (17%) deviated significantly for CPS ≥ 20 cut‐off.ConclusionIn the first 3 years of PD‐L1 assessment in HNSCC, the testing landscape became more uniform. However, interlaboratory variation in PD‐L1 positivity rates between Dutch laboratories was substantial. This implies that there is a need for further test standardisation to reduce this variation.
Effect of different monochromatic lights on nutritional, antioxidant properties and spore microstructure of dried mushroom (Suillus granulatus)
Authors: Wang Yafei , Feng Yao , Xu Heran , Xia Rongrong , Li Yunting , Hou Zhenshan , Ren Hongli , Xin Guang 
Published: April 2024

SummaryMonochromatic light has been shown to improve the flavour quality of dried mushrooms, but its effect on the nutritional, bioactive, antioxidant, rehydration and textural properties has not been studied. In this study, the effects of monochromatic light on these qualities of the dried Suillus granulatus were investigated and the porous characteristics and spore morphology were observed. The results showed that contents of soluble sugars, soluble proteins, flavonoid, phenolics, DPPH and rehydration under blue light were higher on the sixth day, it was 1.85 times, 1.58 times, 1.27 times and 1.20 times of the lowest content, respectively. While ABTS and FRAP were higher on the ninth day. The values are 33.5% and 0.749 mmol/LFeSO4, respectively. The texture of rehydrated mushrooms was higher under red light and lower under blue light. Clear pore structure and severely deformed spores can be observed under blue light, revealing the reason why mushrooms have better qualities under light. Correlation analysis results showed that nutrients, active components, antioxidant activity and rehydration showed a strong positive correlation. Totally, blue light is a promising processing technology to improve the quality of dried mushrooms.
The role of germinating, roasting and boiling on bioactive properties, fatty acid, phenolic components and biogenic element contents of soybean seeds
Authors: AlJuhaimi Fahad , Babacan Rabia , Ahmed Isam A. Mohamed , Özcan Mehmet Musa , Uslu Nurhan , Karrar Emad 
Published: April 2024

SummaryIn this study, the effects of germination, roasting and boiling processes on bioactive substances, mineral profiles, fatty acid composition and phenolic profiles present in soybean seeds and soybean oil extracted from soybean were investigated. While the acidity value of the crude and roasted soybean seed oils are 0.89% and 1.09%, the acidity values of the germinted and boiled soybean oils were 1.58% and 1.21%, respectively. The free fatty acid value of the germination sample group was established to be higher than the other treatment groups. The amounts of total phenolic substance were reported between 10.22 and 33.78 mgGAE/100 g. Linoleic acid amounts of soybean oil varied between 55.72% and 56.14%. The total carotenoid and flavonoid amounts of seeds were measured to be between 0.53 (control) and 2.83 μg g−1 (germination) to 43.60 mgCE kg−1 (boiled) to 126.60 mgCE kg−1 (roasting), respectively. Protein results of the seeds were established between 43.94% (control) and 46.94% (germination). The amount of K ranged from 10 883 (boiled) to 13 994 mg kg−1 (roasting), while the amount of P range from 5340.8 (control) to 5695.9 mg kg−1 germination. The amount of Ca of the samples varied between 4606.1 (control) and 5216.1 (boiled). While linoleic acid is determined at the highest rate in soybean oil obtained from crude soybean, linoleic acid amount was determined as highest in oil obtained after roasting, germination and boiling processes applied to soybean rutin contents of soybean seed samples were determined between 3.52 and 7.81 mg kg−1. Boiling and germination increased the routine value in soybean seed samples and was determined as 7.62 and 7.81 mg kg−1, respectively. Roasting, germination and boiling processes reduced the cinnamic acid values of soybeans.
Surviving the storm: navigating the quadruple whammy impact on Europe's food supply chain
Authors: Jagtap Sandeep , Trollman Hana , Trollman Frank , Garcia‐Garcia Guillermo , Martindale Wayne 
Published: April 2024

SummaryThis article explores the impact of the ‘Quadruple Whammy’ consisting of Brexit, COVID‐19, Conflicts (Russia‐Ukraine and Israel‐Palestine) and Natural disasters on the food supply chain in Europe. This research adopted a two‐phase methodology comprised of the e‐Delphi technique followed by the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta‐Analyses) approach within the context of these four identified challenges. The objective of this article is to analyse the challenges faced by the European food supply chain due to these four factors. The article examines the impact of political isolationism such as Brexit on trade, cost and border controls, while also discussing the effects of COVID‐19 on labour, supply chains and the rise of e‐commerce. In addition, the article examines the impact of conflicts on food access and availability and the role of international aid and assistance. The effects of natural disasters, such as the Turkish and Moroccan earthquakes, floods in Spain and Portugal and the Moroccan drought, on food security are also analysed. The article offers several strategies for taming the quadruple whammy, such as investing in local food production and supply chains, diversifying supply chains and trade partnerships and strengthening food safety regulations and standards. The importance of building resilience and preparedness in the face of these challenges is emphasised and the article concludes with final thoughts and recommendations.