bluuebunny/crossref_metadata_2025_split huggingface dataset:
Temporal mechanisms in frontoparallel stereomotion revealed by individual differences analysis
Authors: Llamas‐Cornejo Ichasus , Peterzell David H. , Serrano‐Pedraza Ignacio 
Published: April 2024

AbstractMasking experiments, using vertical and horizontal sinusoidal depth corrugations, have suggested the existence of more than two spatial‐frequency disparity mechanisms. This result was confirmed through an individual differences approach. Here, using factor analytic techniques, we want to investigate the existence of independent temporal mechanisms in frontoparallel stereoscopic (cyclopean) motion. To construct stereomotion, we used sinusoidal depth corrugations obtained with dynamic random‐dot stereograms. Thus, no luminance motion was present monocularly. We measured disparity thresholds for drifting vertical (up‐down) and horizontal (left‐right) sinusoidal corrugations of 0.4 cyc/deg at 0.25, 0.5, 1, 2, 4, 6, and 8 Hz. In total, we tested 34 participants. Results showed a small orientation anisotropy with lower thresholds for horizontal corrugations. Disparity thresholds as a function of temporal frequency were almost constant from 0.25 up to 1 Hz, and then they increased monotonically. Principal component analysis uncovered two significant factors for vertical and two for horizontal corrugations. Varimax rotation showed that one factor loaded from 0.25 to 1–2 Hz and a second factor from 2 to 4 to 8 Hz. Direct Oblimin rotation indicated a moderate intercorrelation of both factors. Our results suggest the possible existence of two somewhat interdependent temporal mechanisms involved in frontoparallel stereomotion.
Study on the Pb(II) adsorption mechanism on acid‐modified ceramsite made from sewage sludge and industrial solid wastes
Authors: Feng Li‐Juan , Li Jia‐Li , Ou Yang‐Yang , Liu An‐Rong 
Published: April 2024

AbstractCeramsite was made from sludge, phosphogypsum, and red mud and then modified with different concentrations of hydrochloric, nitric, or citric acid. The resulting composite ceramsite was subsequently utilized for the adsorption of Pb(II). The maximum adsorption capacities of hydrochloric acid– and nitric acid–modified ceramsites were 90.38 and 88.57 mg/g, respectively, which were much higher than those of unmodified ceramsite (66.86 mg/g) and citric acid–modified ceramsite (57.85 mg/g). The variation of isoelectric point, acidic and basic groups, and Fourier transform infrared spectra of ceramsite were compared before and after adsorption. A decrease of isoelectric point implied weakening of electrostatic repulsion between Pb(II) and the modified ceramsite. Functional groups, such as O─H, C═O (or C═C), and Si─O─Si (or Al─O─Al), were involved in the adsorption. In addition, phenol hydroxyl, which exhibited a significant increase in modified ceramsite and a noticeable decrease after adsorption, was the most important group. Besides, the modified ceramsite had larger specific surface areas and pores (30.66 g/m2, .11256 cm3/g), more functional groups, and lower isoelectric points (8.57), which were favorable for adsorption. The adsorption processes described by pseudo‐second‐order kinetics were controlled by chemical adsorptions. Isothermal studies indicated that monolayer adsorption occurred on hydrochloric acid–modified ceramsite and multiple processes occurred on nitric acid– and citric acid–modified ceramsites. Thermodynamic analysis confirmed Pb(II) adsorption on modified ceramsite was spontaneous and endothermic.
Complement inhibition in paroxysmal nocturnal hemoglobinuria: From biology to therapy
Authors: Versino Francesco , Fattizzo Bruno 
Published: April 2024

AbstractComplement inhibitors are the mainstay of paroxysmal nocturnal hemoglobinuria (PNH) treatment. The anti‐C5 monoclonal antibody eculizumab was the first treatment to improve hemolysis, thrombotic risk, and survival in PNH although at the price of a life‐long intravenous fortnightly drug. Additionally, suboptimal response may occur in up to 2/3 of patients with persistent anemia due to incomplete control of intravascular hemolysis, development of upstream C3‐mediated extravascular hemolysis (EVH), or concomitant bone marrow failure. Ravulizumab, a longer half‐life anti‐C5 developed from eculizumab, administered every 8 weeks, improved patient convenience, and reduced pharmacokinetic breakthrough hemolysis (BTH) by establishing more stable anti‐C5 concentrations. More recently, several other anti‐C5 compounds (crovalimab, pozelimab, tesidolumab, cemdisiran, zilucoplan, and coversin) are on study in clinical trials. Upstream inhibition of complement cascade was also explored with the anti‐C3 pegcetacoplan, and with the alternative pathway inhibitors iptacopan (anti‐factor B) and danicopan (anti‐factor D). These drugs efficiently target EVH and are able to improve anemia and transfusion need in suboptimal responders to anti‐C5. The route and schedule of administration (twice weekly subcutaneously for pegcetacoplan and twice or thrice oral daily dosing for iptacopan and danicopan, respectively) are very convenient but pose novel issues regarding adherence. Additionally, both anti‐C5 and upstream inhibitors do not resolve the unmet need of pharmacodynamic BTH events due to complement amplifying conditions such as infections, traumas, and surgery. In this review, we will recapitulate PNH physiopathology, clinical presentation, and diagnosis and describe available and developing drugs that will lead to a precision medicine approach for this rare though heterogenous disease.
Infant feeding practices and body mass index up to 7.5 years in the French nationwide ELFE study
Authors: Camier Aurore , Cissé Aminata Hallimat , Heude Barbara , Nicklaus Sophie , Chabanet Claire , Bernard Jonathan Y. , Lioret Sandrine , Charles Marie Aline , de Lauzon‐Guillain Blandine 
Published: April 2024

SummaryBackground/ObjectivesThe infant diet represents one of the main modifiable determinants of early growth. This study aimed to investigate the associations of infant feeding practices with body mass index (BMI) until 7.5 years.Subjects/MethodsAnalyses were based on data from the French nationwide ELFE birth cohort. Data on breastfeeding (BF) and complementary feeding (CF) were collected monthly from 2 to 10 months. Infant feeding practices were characterized using principal component analyses (PCA) and hierarchical ascendant classification. BMI z‐score was computed at 1, 2, 3, 5 and 7.5 years, from data collected in the child's health booklet; 7.5‐year overweight was defined according to IOTF references. Associations between infant feeding practices and BMI were investigated by linear regression models adjusted for main confounders.ResultsEver breastfeeding was not associated with BMI up to 7.5 years. Compared to intermediate breastfeeding duration (1 to <3 months), longer breastfeeding duration (≥6 months) was related to lower 1‐year BMI, but not at older ages. Compared to the recommended age at CF introduction (4–6 months), early CF (<4 months) was related to higher BMI up to 5 years with a similar trend at 7.5 years, but not to the risk of overweight. The PCA patterns characterized by early baby cereal introduction and late food pieces introduction or by frequent intake of main food groups were related to a lower BMI up to 7.5 years.ConclusionBreastfeeding was related with a lower BMI in infancy but not thereafter, whereas an early CF initiation (<4 months) was associated with a higher BMI in childhood.
Urinary catheterisation among nurses in Sweden: A survey on routines and guideline adherence
Authors: Luque González Manuel , Armas Moreno Clara , Mòdol Vidal Max , Endrényi Szilvia , Castellano Santana Pedro Raúl , Muñoz Calahorro Carmen , Serrano Muñoz Marta , Santos Tiago 
Published: April 2024

AbstractIntroduction and ObjectivesBladder catheterisation is a common and invasive procedure with guidelines that can prevent or minimize associated complications. However, healthcare workers often do not follow these guidelines. Healthcare systems' strategies, policies and practices which support quality of care could affect the level of guideline adherence. This could be explored by studying adherence in a high‐performing healthcare system with extensive monitoring of health outcomes, such as Sweden. Moreover, there is a lack of relevant literature about the knowledge, attitudes and practices of healthcare workers regarding CAUTI. This study therefore aims to investigate how nurses in Sweden perform bladder catheterisation and identify potential ways to improve adherence to guidelines in order to decrease complications.Materials and MethodsA cross‐sectional survey was performed between the 21st and 29th of May 2020. A survey including questions on supervision during bladder catheterisation, maintenance of sterility, accidental urine spillage, and potential advantages of a urinary catheter with an integrated valve was distributed through social media channels to Swedish nurses. Participants were anonymous and no personal data was collected. The data was tabulated and analysed using descriptive statistics (Microsoft Excel).ResultsA total of 910 nurses responded to the survey. Respondents worked across several settings, and 76.1% worked within surgical, internal medicine, prehospital, geriatrics or primary care clinics. Respondents had various levels of experience in placing catheters, with 40.3% having inserted less than 50 catheters, and 31.5% having inserted more than 100.54.9% reported that someone had checked that they followed guidelines during catheter insertion. A majority (66.5%) either often or sometimes received assistance during insertion, with only 9.3% always receiving help. Only 9.9% reported always being able to maintain sterility during insertion.58.6% reported inadvertently spilling urine on the material (protective sheet, diaper) 1–5 times during their last 10 catheter insertions, 24.8% reported spilling on the bed or linen, and 15.7% on themselves, the patient or other healthcare staff.When asked about the potential advantages of a urinary catheter with an integrated valve, the most significant advantage cited was the reduced risk of urine leakage (63%), followed by the absence of stress from not having to connect a urine bag or plug (52.1%). 96% of respondents see at least one advantage in such a device.ConclusionsNearly half of nurses have not been audited concerning guideline adherence during bladder catheterisation. Only 10% are able to always maintain sterility, and it is common to spill urine during the catheterization process. Virtually all nurses see at least one advantage in a urinary catheter with an integrated valve.
Advanced practice nursing in the field of pelvic floor disorder – Lessons learned 5 years after role implementation
Authors: Enaux Jennifer , Ortner Manuela , Kobleder Andrea , Knecht Christiane 
Published: April 2024

AbstractIntroductionPelvic floor disorder is a widespread chronic disease that confronts patients with a variety of physical and psychosocial challenges. An interprofessional team from a hospital region of eastern Switzerland created a specialized health service for this patient population and expressed the need for support by an APN to further develop interprofessional care. A retrospective look, 5 years after the role was implemented, reveals success factors, challenges and insights that can be utilized for similar and future projects.Method and AnalysisIn 2018 and 2019, a stakeholder‐oriented, participatory evaluation research was conducted to shape the role of the APN in the field of pelvic floor disorders. Ten interviews with internal and external experts in the field of pelvic floor disorder were analysed by thematic qualitative text analysis according to Kuckartz. A comparison between the original and the current profile illustrates its further development. Internal controlling shows the workload and number of patient contacts over the years 2018 to 2023. From a management perspective, the organizational and professional policy challenges are highlighted.ResultsIn 2018, the APN's scope of practice was described in eight areas, which were assigned to four APN competencies: direct clinical practice, collaboration, counselling, and evidence‐based practice. In 2022, 1211 different patient cases were treated in 1956 APN consultations. 64% of patients were women with interstitial cystitis. The focus was on direct clinical practice along the entire treatment pathway. The APN is predominantly the first and ongoing point of contact and coordinator of interprofessional treatment. The APN focuses on counselling and educating patients and their relatives, in particular on self‐management, for example, on the use of aids and the importance of self‐care. The number and complexity of the diagnostic and treatment interventions carried out by the APN have increased and are supported by expanding and extending competencies. The difficulty of recruiting nurses with a Master's degree, the legally unclear competence profile of APNs and the lack of cost coverage for APN services posed challenges in the development of this patient‐centred care model and required innovative solutions.DiscussionThe initially assumed scope of practice of the APN is still evident 5 years after implementation but is constantly evolving. Although delegated medical activities are carried out by the APN, the focus remains on the original nursing competences. The increase in the number of patients indicates the need for and successful establishment of the care model presented. Professional policy changes are urgently needed to enable the development of patient‐centred, innovative APN roles, both financially and legally.
Treatment selection and real‐world analysis of immunotherapy with or without chemotherapy in PD‐L1‐high metastatic non‐small cell lung cancer
Authors: Smith Samuel , Kao Steven , Boyer Michael , Franco Michael , Moore Melissa 
Published: April 2024

AbstractBackgroundLung cancer is the leading cause of cancer death in Australia. Immunotherapy has improved outcomes in patients with metastatic non‐small cell lung cancer (NSCLC). Pembrolizumab is approved in first‐line treatment as single‐agent immunotherapy (SAI) or combination chemoimmunotherapy (CIT). In metastatic NSCLC programmed death‐ligand 1 (PD‐L1) ≥50% either regimen may be used.AimsWe aim to identify patient and tumour characteristics that influence treatment selection.MethodsThis is a retrospective observational study. Pharmacy records identified patients with metastatic/recurrent NSCLC receiving pembrolizumab at two metropolitan centres in Victoria, Australia, since 2018. Demographics, tumour characteristics, Charlson Comorbidity Index (CCI) and treatment data were collected. Descriptive and multivariate analyses were performed.ResultsSixty‐one patients had metastatic NSCLC PD‐L1 ≥50% and received pembrolizumab with median age of 65.6 years, Eastern Cooperative Oncology Group 0–1 in 82%. CIT was administered to 23% (14) with no difference in rate of delivery between centres (P = 0.808). CCI mean score differed (3.38 SAI vs 2.36 CIT, P = 0.042). Patients with high CCI score (≥2) were less likely to receive CIT (OR = 0.15, P = 0.003, 95% confidence interval (CI) 0.04–0.57). Primary tumours over 5 cm were more likely to receive CIT (OR = 3.74, P = 0.043, 95% CI = 1.04–13.42). Site‐specific metastases of liver, brain and pericardial effusion were not associated with CIT.ConclusionsPatients with higher comorbidity score were less likely to receive CIT, suggesting chemotherapy avoidance in comorbid patients. Larger tumours are associated with CIT use, indicating that oncologists may use tumour size as a surrogate of disease burden. Limitations include small sample size and data cut‐off. Future prospective studies could incorporate comorbid status and a validated disease burden score to stratify patients.
Techno‐eustress creators: Conceptualization and empirical validation
Authors: Tarafdar Monideepa , Stich Jean‐François , Maier Christian , Laumer Sven 
Published: April 2024

AbstractTechnostress is an inevitable part of work life. This paper takes a step toward mastering it by focusing on positive stress that Information Systems (IS) creates for IS users, known as techno‐eustress. Factors that create techno‐eustress are known as techno‐eustress creators, which we conceptualise as cognitions experienced by IS users, that IS positively challenges and motivates them to enhance their work. They are important to study because they represent foundational opportunities for professional achievement and growth emanating from IS use. Drawing from theories of psychological eustress, self‐determination and proactive work, this paper theorises and validates an instrument to measure techno‐eustress creators. We establish the construct's validity and examine its nomological relationships based on data collected from working professionals who used IT for their work. We draw on data from two qualitative studies (N = 35) and three quantitative surveys (N = 980) conducted at different points in time. We validate techno‐eustress creators as a second‐order reflective construct having four dimensions: techno‐mastery, techno‐autonomy, techno‐enrichment and techno‐relatedness. We examine its nomological relationships with factors that create techno‐distress, IT strain, and user satisfaction. We contribute to the literature by theorising and validating four ways in which IS users are challenged and motivated by IS to enhance their work. We inform to managerial practice by drawing attention to how organisations can strengthen the different ways employees experience the creators of the ‘good’ stress that use of IS generates.
Economic globalization and unemployment: Evidence from high‐, middle‐ and low‐income countries
Authors: Pal Shreya , Villanthenkodath Muhammed Ashiq 
Published: April 2024

AbstractThis study intends to empirically evaluate the effects of economic globalization and its components (i.e. trade and financial openness) on unemployment in high‐, middle‐ and low‐income countries from 1991 to 2020. Further, it considers real GDP per capita (sectoral divisions of income, i.e. agriculture, industry and service sector) and urbanization as control variables in the unemployment function. On the empirical front, this study employs the Panel Dynamic Simulated ARDL model and the Kernel‐Based Regularized Least Squares for long‐run influence estimations. The emanating outcome of these analyses states that economic globalization destroys employment opportunities for low‐income countries as it enhances unemployment in the long run. However, in high‐ and middle‐income countries, economic globalization creates employment, which implies reducing unemployment in the long run. The result also indicates that trade and financial openness destroy employment opportunities in low‐income countries. Although trade openness in middle‐income countries shows the same effect, financial openness does not mimic the same. For high‐income countries, trade openness reduces unemployment, but financial openness fosters it. Therefore, these findings indicate that to keep unemployment at a low level, policies related to the opening up of the economy in terms of factor mobility, offshoring, outsourcing and international trade need to be implemented in low‐income countries. Moreover, a similar consideration is needed for high and middle‐income countries to avoid faraway repercussions on unemployment due to becoming a peripheral country.
Age and growth of the blue shark Prionace glauca (Linnaeus, 1758) in the Ecuadorian Pacific: Bayesian multi‐models
Authors: Nicole Suárez‐Aguilar , Fernanda Zambrano‐Cedeño , Mendoza‐Nieto Klever , Briones‐Mendoza Jesus 
Published: April 2024

AbstractThe blue shark Prionace glauca plays a critical role as a predator in marine ecosystems but is threatened by by‐catch. To obtain more precise biological data, a Bayesian approach was used, and 536 vertebrae samples collected during 1 year at the landing stage called “Playita Mía” Manta, Ecuador, were analysed. The objective was to estimate the age and growth parameters of the species. The size of the specimens varied between 116 and 310 cm in total length (TL). Using a Bayesian approach based on the Markov Chain Monte Carlo (MCMC) method, growth parameters were evaluated. The von Bertalanffy model was the one that best fitted the data and provided more adequate estimates (females: = 325.50 cm, = 53.23 cm, and k = 0.12 years; males: = 331.47 cm, = 51.59 cm, k = 0.12 years −1; combined sexes: = 329.65 cm, = 53.64 cm, k = 0.11 year−1). The results indicated that females and males have a similar growth, and that the species has a slow growth. Further studies using multi‐model Bayesian approaches and covering a broader range of sizes in the Pacific Ocean are suggested. These studies will provide crucial information for the management and conservation of this species.
Assessment of the chemical profile and potential biocontrol of Amphora coffeaeformis against foodborne pathogens and Culex pipiens L. to ensure food safety
Authors: Abdel‐Haleem Doaa R. , Marrez Diaa A. , El Raey Mohamed A. , Emam Mahmoud , Seif Mohamed , Farag Shaimaa M. 
Published: April 2024

AbstractThe extensive use of synthetic antibiotics and insecticides in controlling microbes and insect spreads led to a build‐up of resistance strains and caused negative impacts on human health through bioaccumulation in food and the environment. The present study assessed the antimicrobial activity of Amphora coffeaeformis (A. coffeaeformis) ethanolic extract against foodborne pathogenic microbes as well as assessed its ability to control Culex pipiens L. (C. pipiens) larvae. The gas chromatography–mass spectrum (GC/MS) and high‐performance liquid chromatography (HPLC) analysis showed that A. coffeaeformis extract was rich with phenolic compounds, organosulfur compounds, carboxylic acids, amino acids, organic quinoline, dipeptide and monosaccharide. The extract of A. coffeaeformis showed antibacterial capability against all tested bacteria, with minimal inhibition concentration (MIC) values ranging from 20.2 to 66.7 g/mL, as well as antifungal effects against all tested mycotoxigenic fungi, with MIC values ranging from 113.62, 68.95 and 49.37 μg/mL mg/mL. Furthermore, the extract showed high larvicidal activity against C. pipiens larvae at 24, 48, and 72 h, respectively. LC50 values decreased gradually with the treatment period. Likewise, the adult emergence and growth index were significantly negatively related to increasing extract concentrations. Moreover, the extract exhibited a noteworthy depletion in the reproductive potential and increased sterility index of C. pipiens females developed of treated larvae. Besides a reduction in egg hatching percent, increase pupal malformations, increase and adult abnormalities. C. pipiens biochemical markers; glutathione‐S‐transferase, carboxylesterase, acetylcholinesterase, α‐esterase and cytochrome P‐450 showed significant alteration after the extract exposure. Overall, these findings promise the application possibility of A. coffeaeformis extract as a biopreservator against foodborne pathogens and as bioinsecticides for mosquito control as well.