bluuebunny/crossref_metadata_2025_split huggingface dataset:
P-glycoproteins in the Pathology and Treatment of Alzheimer's Disease
Authors: Aljohani Raghad H. , Alruwali Nouf F. , Alrashedi Shorooq M. , Yousef Somaya M. , Alobaidan Shahad T. , Elsherbiny Nehal M. , Atteia Hebatallah H. 
Published: March 2024

:
Alzheimer's disease (AD), a central cause of dementia, is characterized by the accumulation
of amyloid β- peptide (Aβ) peptides in the brain. P-glycoprotein (P-gp), a highly expressed protein
in the BBB, plays a fundamental role in transporting Aβ from the brain to the blood and protecting
the blood-brain barrier (BBB). The dysfunction or decreased abundance of this transporting protein
is associated with the accumulation of Aβ, leading to dementia and cognitive deficits. In this
review article, we consolidate the existing literature on the impact of P-gp in the pathophysiology
and therapy of AD. Current evidence claims that p-gp is involved in AD pathology and that enhancing
the activity of this transporter may be a promising therapeutic approach to hinder AD progression.
There is also a growing interest in P-gp as a potential therapeutic target for AD. Hence, ongoing
clinical trials and research should investigate P-gp inhibitor efficacy as a therapeutic approach for
improving AD drug delivery to the brain and treatment outcomes.
Rituximab Induced Flare of Psoriatic Arthritis in a Patient with Devic's Syndrome: A Case Report
Authors: Gonzales Sofia Audrey B. , Mortezaei Kiana , Arkfeld Daniel G. 
Published: March 2024

Introduction/Background:
Devic’s syndrome is a rare autoimmune disorder that occurs
when the body's immune system damages and mistakenly attacks the optic nerves and spinal
cord, leading to numerous neurological symptoms such as inflammation, weakness, numbness,
and vision problems. Rituximab has mainly been utilized as an immunosuppressive therapy for patients
with Devic’s syndrome. Although evidence has shown that rituximab is efficient and well
tolerated in treating patients with Devic’s syndrome, there is the possibility of rituximab exacerbating
severe psoriasis and psoriatic arthritis flare.

Case Presentation:
In this paper, we describe a case of a 58-year-old female with Devic’s syndrome,
blindness, and neurological involvement who responded exceptionally well to rituximab
but developed a severe flare of psoriatic arthritis. After withdrawing from the use of rituximab,
her psoriatic arthritis symptoms had resolved. However, she did have another episode of blindness,
and rituximab was started once again. Although her vision improved, her psoriatic arthritis
symptoms had reoccurred. The patient was switched to eculizumab and ustekinumab, which controlled
both her psoriatic arthritis and Devic’s syndrome.

Conclusion:
Very few reports have identified rituximab to induce a flare-up of psoriatic arthritis,
raising uncertainty regarding its potential effects on psoriatic symptoms. The precise mechanism
underlying the exacerbation of psoriatic arthritis by rituximab remains uncertain. This case report
highlights that rituximab can worsen psoriasis and psoriatic arthritis, and that the complexities of
Devic’s syndrome may require medication adjustments.
Improving Type 2 Diabetes Care with Extended-Release Metformin:
Real-Life Insights from a Physician Educational Program
Authors: Molteni Laura , Marelli Giuseppe , Castagna Giona , Brambilla Luciano , Acerbis Maurizio , Alberghina Fabio , Carpani Antonio , Chiavenna Erika , Ferlini Maria Grazia , Impellizzeri Carmen , Paredi Roberto , Rigamonti Alberto , Rivolta Giuseppe , Disoteo Olga Eugenia 
Published: March 2024

Background:
Compared to Immediate-Release (IR) metformin, Extended-Release
(ER) metformin reduces side effects and pill burden while improving adherence; however, there
is little real-life data on patient satisfaction with this innovative formulation to guide physicians
toward a more holistic approach.

Objective:
Our goal is to train general practitioners on holistic patient management, with the
aim of increasing patient satisfaction and treatment adherence, reducing side effects, and improving
quality of life in patients with poor tolerance to metformin-IR.

Materials and Methods:
We designed an educational program for physicians called SlowDiab,
aimed at establishing a holistic patient approach. In this context, adult patients with T2DM who
experienced gastrointestinal discomfort with metformin-IR were enrolled and switched to metformin-
ER. Data on glycemic control were collected at baseline and 2 months after switching. A
survey was carried out on patients to assess their level of satisfaction.

Results:
In 69 enrolled patients (mean (min-max) age, 68.2 (41-90)), side effects decreased after
switching from 61.8% to 16.2% (p < 0.01), and the mean perceived burden of adverse events on
a scale of 1 to 10 also decreased (6.17 vs. 3.82; p < 0.05). Among patients previously intolerant
to metformin-IR, 74.3% reported no longer experiencing any side effects after the switch. The
mean number of tablets taken daily (2.28 vs. 1.66; p < 0.01) and mean plasma glycated hemoglobin
(HbA1c) values (7.0% vs. 6.7%; p < 0.05) decreased, while 93.8% of patients were satisfied
with the treatment change. Moreover, 84.2% reported an improvement in glycemic control
after the switch.

Conclusion:
In a real-life setting, an educational program for general practitioners confirmed
that metformin ER reduces side effects and improves pill burden, therapeutic adherence, and
patient satisfaction compared to metformin IR.
Taraxerol: A Promising Natural Product in the Management of Inflammation
Authors: Jyoti Uma , Mittal Neeraj , Singh Thakur Gurjeet , Singh Randhir , Devi Sushma 
Published: March 2024

:
Inflammation is a complex biological process that plays an important role in many clinical
disorders. The natural plant and its secondary metabolites play an important role in the prevention
and treatment of inflammation. Taraxerol is a pentacyclic triterpenoid found in medicinal plants,
fruits, and vegetables, and is a potent anti-inflammatory agent. This review explains the molecular
mechanism of the anti-inflammatory effects of taraxerol and its interactions with many molecular
targets, including NF-κB, MAPKs, and COX. Furthermore, the effects of taraxerol on oxidative
stress, cell function, and inflammatory cell signaling have been comprehensively described. This
review addresses the limitations and obstacles in taraxerol research, as well as provides insights for
future investigations. The findings highlight the need for additional research to completely understand
the therapeutic potential and clinical applications of taraxerol in the treatment of inflammatory
diseases.
Biogenic Amines: Catalysis, Quality, and Safety Aspects of Food Items Consumed in Saudi Arabia
Authors: Mir M. Amin 
Published: March 2024

Introduction:
In this study, the identification and quantification of biogenic amines in
45 commonly consumed food samples in Saudi Arabia were carried out. The enzymes responsible
for producing these biogenic amines include spermidine (SPD), putrescine (PUT), tryptamine
(TRP), tyramine (TYR), and histamine (HIS), which are synthesized through organo-catalytic pathways.

Method:
The diverse range of samples analyzed encompassed various types of beef, pickle varieties,
canned fish, vegetables, chicken varieties, spices, fruits, and salad ingredients. Sample preparation
involved the use of dansyl chloride after aqueous extraction, followed by isolation and analysis
using reversed-phase HPLC with a UV detector. In five beef samples, mean concentrations of
SPD, PUT, TRP, HIS, and TYR were identified as 9.41, 8.98, 155.8, 100.8, and 304.2 mg kg-1,
respectively. Canned fish samples exhibited mean concentrations of TRP, PUT, HIS, TYR, and
SPD at 71.6, 3.88, 29.2, 2.56, and 2.02 mg kg-1, respectively.

Result:
Among five pickle samples, mean concentrations of TRP, PUT, HIS, TYR, and SPD were
reported as 118.8, 39.12, 35.2, 27.2, and 2.56 mg kg-1, respectively. Chicken samples primarily
contained TRP, HIS, and SPD as the identified biogenic amines, with mean concentrations of 87.2,
105.6, and 5.22 mg kg-1, respectively. Fruit samples generally exhibited low levels of all enzymes
except for TRP.

Conclusion:
It was found that vegetables, seasonings, and salad ingredients either had undetectable
or low quantities of biogenic amines.
Exploring the Application of Artificial Intelligence in Cosmetics and
Beauty Industry
Authors: Mathur Harshita , Chaudhary Anurag , Sharma Devkant , Sharma Alok 
Published: March 2024

Abstract:
The present work highlights how AI can enhance the personalized cosmetic experience
based on the digitalization of make-up by consumers, the selection of perfect product characteristics
and optimization of new cosmetic products on the basis of big data. Moreover, the different
AI technologies applied in cosmetics have also been presented in a concise manner. Cosmetic
companies are advancing and are expected to be even more advanced in the future. The present
work could provide a new direction in the development of an AI algorithm approach for cosmetic
companies’ development and for building a database for cosmetic applications.
Dandelion (Taraxacum officinale): A Promising Source of Nutritional and Therapeutic Compounds
Authors: Laila Umi , Kaur Jaspreet , Sharma Kartik , Singh Jyoti , Rasane Prasad , Kaur Sawinder , Bhadariya Vishesh 
Published: March 2024

Background:
Taraxacum officinale, commonly referred to as dandelion, is a self-growing plant/ weed in various parts of India and the rest of the world (particularly the northern hemisphere). The plant’s chemical composition, including sesquiterpene lactones, saponins, flavonoids, phenols, and many other compounds, contributes positively to the human body, promoting overall health.

Aim:
This review aims to shed light on the therapeutic potential of dandelion by summarizing its nutritional benefits, phytochemical constituents, and effectiveness in addressing health conditions like diabetes, inflammation, and cancer. It also provides insights into the applications of this plant beyond the food industry to gain researchers' attention to unravel the unexplored aspects of this therapeutic plant. It will further help in laying specific considerations, which are required to be taken into account before the development of functional foods incorporated with dandelion.

Scope and approach:
Being rich in essential vitamins, minerals, and other phytoconstituents, dandelion is a natural remedy for various ailments. Whether consumed raw or cooked, the plant’s inclusion in the diet poses potential therapeutic effects on conditions such as diabetes, inflammation, liver disease, and tumors. It also aids in immune system modulation and fights infections by targeting microbes at their root. Researchers have developed various value-added food products by incorporating different parts of dandelion.

Conclusion:
This review highlights the therapeutic potential of dandelion, emphasizing its effectiveness against various health conditions. Insights into dosage, toxicity, and diverse applications further underscore its role as a versatile and promising natural remedy.
National Security Priorities for a Sustainable Energy Transition
Authors: Kapustina Yu. A. , Dzhancharova G. K. , Kulikova N. N. , Derevyagin D. S. 
Published: March 2024

Relevance. Problems of the sustainability of national economic systems continue to remain relevant for a long time. States continue to interact on climate agendas and environmental topics in a tense geopolitical situation. Expanding the implementation of carbon footprint reduction technologies is becoming a prerequisite for partnerships and entry into new international markets for the supply of products and services. National priorities of states today are moving closer together due to the growing climate crisis, which dictates the need to intensify work on the implementation of ESG projects. The purpose of the study was to analyze the current state of the movement to reduce the carbon footprint and the results of the implementation of declared initiatives within the framework of international agreements. Objectives. The article set and consistently solved the following tasks: a review of the current state of climate change in the environment and the impact of declining environmental quality on the health and longevity of the population was carried out, an assessment was made of the sectoral contribution of various sectors of the economy to the formation and accumulation of greenhouse gases in the atmosphere, an assessment of modern compensation carbon impact tools. Methodology. The work used methods of logical analysis, content analysis, statistical analysis of data on emissions and inputs, graphical and horizontal analysis, generalization and systematization of data. Results. An assessment of the current state of this problem made it possible to summarize the conclusions and results of research on this topic and to identify the main national priorities related to the implementation of strategies for switching to renewable energy sources. Conclusions. The article provides an overview of the level of implementation of resource-saving technologies in various sectors of the Russian national economy. Conclusions are drawn about the need to continue the environmental modernization of the national economic system and expand interstate cooperation on climate change issues and a sustainable energy transition to resource-saving technologies.
Analysis of Forest Use (Including Forest Income Generation) in the Context of the Existing Regulatory Framework
Authors: Stepanova Yu. N. , Tretyakov A. G. 
Published: March 2024

The relevance. Trends in achieving sustainable development of the forestry economy and determining future prospects for the industry set clear goals for decision-making, which is possible with reliable and complete information about the achieved indicators of the forestry sector. There is a need to analyze the use of Russian forests, as well as consider the main directions of forest management, the dynamics of budget revenues, the ratio of payments for the lease of forest areas and the cost of products of industries that use forest resources in their activities. The purpose is to study and analyze the use of forests in the Russian Federation (including the generation of forest income) under the existing regulatory framework for the period 2016-2021. The objectives is to justify the need to modernize existing approaches to determining the value of forest resources. Methodology. When conducting the study, we used official statistical reference books of the Federal State Statistics Service of the Russian Federation, materials from reports of the Ministry of Economic Development, and materials from periodicals. Results. Based on the analysis described above, despite the steady increase in payments to the budget system from the use of forests, their share relative to the cost of products and services of enterprises using forest resources remains insignificant and weakly correlates with changes in activity volumes. Conclusions. Based on the analysis of the use of forests in the Russian Federation (including the generation of forest income) under the existing regulatory framework, it was established that only in a number of federal districts is there stability in the share of forest leases in the structure of the cost of placement. The current situation demonstrates that there is a discrepancy between the assessment of rental costs and the benefits that forest users receive from the exploitation of recreational resources. The presence of negative values actually demonstrates an increase in the benefits of forest users, which is not commensurate with the fees for the forest plot.
Economic and Mathematical Model of the Development of the Digital Ecosystem of the Regional Economy (Using the Example of the Kursk Region)
Authors: Babichev A. O. 
Published: March 2024

Relevance. To form a system of measures for the digitalization of individual regions and the country as a whole, as well as for their effective implementation, it is necessary to develop an economic and mathematical model that allows assessing the current state of the digital ecosystem of the regional economy (DEED). The purpose is development and testing of an economic and mathematical model for the development of the digital ecosystem of the regional economy (using the example of the Kursk region). Objective: systematization of factors and indicators by categories characterizing the development of the digital ecosystem of the regional economy; calculation of indicators for each set of "Factor ‒ Indicator" for the Kursk region for the period from 2016 to 2021; conducting correlation and regression analysis for the categories "Science", "Innovation", "Human Resources", "Education", "Healthcare", "Households", "Business", "Regional Authorities". Methodology. The methodological basis of the study was: the method of statistical processing of information; methods of regression and correlation analysis. Results: factors and indicators are systematized into categories that characterize the development of the digital ecosystem of the regional economy; indicators were calculated for each set of "Factor ‒ Indicator" for the Kursk region for the period from 2016 to 2021; a correlation and regression analysis was carried out for the categories "Science", "Innovation", "Human Resources", "Education", "Healthcare", "Households", "Business", "Regional Authorities". Conclusions. Practical testing of the developed economic and mathematical model using the example of the Kursk region for some processes gave ambiguous results: a low value of the coefficient of determination, as well as non-compliance with the normative values of the Fisher f-criterion, t-criteria for the factor and the free term, which does not means the economic and mathematical model we have developed is incorrect. These results can be explained by the fact that in the region the processes under study, expressed in a certain relationship between the factor and the indicator, are at the initial stage of their formation or have not been formed. The developed economic and mathematical model for the development of the digital ecosystem of the regional economy allows us to assess the current state of the DEER, identify factors that constrain and stimulate its development, determine areas requiring financing, as well as the expected effect of the resources spent.
The Idea of Digital Business Transformation: Models, Changes and New Challenges
Authors: Kulagina N. A. , Chepikova E. M. , Grafov Yu. G. , Goncharov A. Yu. 
Published: March 2024

Relevance. Digital transformation has been one of the key driving forces in the economy over the past few years, and the introduction of digital technologies is becoming an essential condition for an efficient, competitive and sustainable business. The article is devoted to the formation of the concept of digital transformation in the modern business environment, with a focus on the growing new challenges from the external environment. A wide range of studies devoted to this issue highlights various aspects, including barriers, strategies, elements and other components of this complex definition, which leads to the existence of multiple variations of approaches, both to the vision of the essence of digital transformation and its resulting parameters. The purpose of the study is theoretical and methodological elaboration of the issues of the essence of the categorical apparatus of the category "digital transformation of business" and the disclosure of its structural components, as well as clarification for further strategic management and reduction of the consequences of risk determinants. Objectives: analysis of statistical data on the level of digitalization of business in Russia; identification of key elements of digital business transformation; consideration of digital transformation as a business process. Methodology. As part of the study, materials from world rating reports and news agencies were used, as well as developments by representatives of the national scientific school, which was the basis for a critical analysis. Standard methods of statistical processing, generalization, and comparison were used. The method of classification and comparative analysis, as well as methods of structural-functional and strategic analysis are applied. Results. The article presents the main trends of digitalization of business in Russia. The author's approach to understanding the definition of "digital transformation of business" is formulated, its key elements are highlighted. A conceptual model of digital business transformation in the conditions of practical implementation of the basic development strategy is proposed. Conclusions. The technologies that form the basis of digital transformation are revolutionary in themselves, and in their synergetic effect are capable of radically transforming business and society, destroying old business models, thereby contributing to the increase of competitive opportunities and rapid adaptation to chaotically changing market requirements.
A clinical case of persistent Lyme disease in a child
Authors: Pikul K.V. , Ilchenko V.I. , Prylutskyi K.Yu. , Muravlova O.V. , Shaienko Z.O. 
Published: March 2024

Background. The relevance of the study is due to the frequent occurrence of Lyme disease (neuroborreliosis) in the spring-autumn period. Official record of Lyme disease in Ukraine has been conducted since 2000, although the first cases were identified in the 1990s. From 2001 to 2023, the incidence of Lyme borreliosis in Ukraine increased almost by 35 times. Materials and methods. The authors conducted a retrospective analysis of statistical data on Lyme borreliosis morbidity from 2000 to 2023 and the most common cases of infectious pathology in children during this period. As pediatric infectious disease specialists, the authors present a clinical case recently observed in the pediatric infectious unit in Poltava. Results. The diagnosis of Lyme borreliosis is made based on a characteristic clinical picture and a serological confirmation. The latter is crucial in the diagnosis of Lyme borreliosis and includes 2 stages. The first stage is the assessment of immunoglobulin M and G titers by the immunofluorescence assay (IFA). If the result is negative, further investigation is conducted within the first 30 days of symptoms onset by repeated IFA 4–6 weeks after the initial test. If the analysis is conducted ≥ 30 days after the onset of symptoms, further examinations are not carried out, and an alternative diagnosis should be suspected. In case of a doubtful or positive IFA result, the diagnosis is further confirmed by the Western blotting (the second stage). The authors present a case report of a 6-year-old girl M., hospitalized in the pediatric infectious unit of the CE “Municipal Clinical Hospital 1” (Poltava) in March 2023 with a diagnosis of Lyme disease (systemic tick-borne borreliosis), early disseminated stage, myalgia, arthralgia, subacute course, moderate severity. Acetonemic syndrome. Stage 1 deficiency anemia. Metabolic cardiomyopathy. Speech development delay. Conclusions. Therefore, it is crucial to recognize Lyme disease with a progressing or remitting disseminated form, as specific therapeutic approaches exist that are effective for this disabling condition.