bluuebunny/crossref_metadata_2025_split huggingface dataset:
Successful Treatment of Complex and Refractory Rosacea Using Platelet‐Rich Plasma Injection Therapy: Case Series and Review of the Literature
Authors: Pang Xinyue , Tan Lisha , Zhao Boyu , Kong Xiangjun , Wang Huiping , Hou Shuping 
Published: February 2025

ABSTRACTBackgroundRosacea is a chronic inflammatory skin disease that affects a notable proportion of the adult population. Platelet‐rich plasma (PRP) has been widely used to treat various inflammatory diseases due to its potent anti‐inflammatory and antibacterial properties. Considering its therapeutic potential, PRP is emerging as a promising option for managing rosacea.AimsTo evaluate the efficacy and safety of PRP therapy in treating distinct clinical presentations of rosacea and explore its potential as an alternative to systemic treatments, particularly in cases where conventional therapies are contraindicated.MethodsFive patients of rosacea with distinct presentations were treated with PRP therapy. The treatment outcomes were analyzed, and a brief review of relevant literature was conducted to contextualize the findings. Clinical efficacy was assessed using clinical photographs captured at 0 and 30 days after baseline according to the National Rosacea Society Standard (NRSS) grading system. Additionally, the efficacy of combining PRP injections with delicate pulsed light therapy or botulinum toxin injections was assessed.ResultsPRP therapy demonstrated significant efficacy and safety in treating rosacea, offering a viable alternative to systemic treatments. The combination of PRP with delicate pulsed light therapy or botulinum toxin injections showed enhanced therapeutic outcomes, not only alleviating rosacea symptoms but also reducing or eliminating patients' dependence on oral medications.ConclusionsPRP therapy, both as a standalone treatment and in combination with other modalities, represents a promising approach for managing rosacea. These findings highlight the potential of PRP to address the limitations of conventional therapies and improve patient outcomes. Further research is warranted to validate these results and optimize treatment protocols.
Advancing Research on the Future of Work in the Age of Artificial Intelligence (AI)
Authors: Sarala Riikka M. , Post Corinne , Doh Jonathan , Muzio Daniel 
Published: February 2025

AbstractTechnological developments – particularly related to artificial intelligence (AI), machine learning, and digitalization – are disrupting the workplace in unprecedented ways, particularly in professional and knowledge‐intensive sectors. Scholars' views on the implications of these disruptions range from optimism and pessimism to scepticism. Disciplines vary in how extensively they have considered the implications of these technological developments. With much prior work focusing on the more macro‐level phenomena and effects, the role of institutions, organizations and individuals – as well as their interrelatedness – remains less examined. In this introductory article to the special issue, we discuss the scope, extent and new domains of change related to the Future of Work and, especially, to AI. We also reflect on the consequences of these changes as well as the related processes and mechanisms through which they will manifest. Then, we introduce and summarize the articles included in this special issue along the above dimensions. We conclude by reflecting on the overall contribution of the special issue and on future directions for examining the Future of Work from the perspective of management studies.
Subject‐Based Transfer Learning in Longitudinal Multiple Sclerosis Lesion Segmentation
Authors: Gaj Sibaji , Thoomukuntla Bhaskar , Ontaneda Daniel , Nakamura Kunio 
Published: February 2025

ABSTRACTBackground and PurposeAccurate and consistent lesion segmentation from magnetic resonance imaging is required for longitudinal multiple sclerosis (MS) data analysis. In this work, we propose two new transfer learning‐based pipelines to improve segmentation performance for subjects in longitudinal MS datasets.MethodIn general, transfer learning is used to improve deep learning model performance for the unseen dataset by fine‐tuning a pretrained model with a limited number of labeled scans from the unseen dataset. The proposed methodologies fine‐tune the deep learning model for each subject using the first scan and improve segmentation performance for later scans for the same subject. We also investigated the statistical benefits of the proposed methodology by modeling lesion volume over time between progressors according to confirmed disability progression and nonprogressors for a large in‐house dataset (937 MS patients, 3210 scans) using a linear mixed effect (LME) model.ResultsThe results show statistically significant improvement for the proposed methodology compared with the traditional transfer learning method using Dice (improvement: 2%), sensitivity (6%), and average volumetric difference (16%), as well as visual analysis for public and in‐house datasets. The LME result showed that the proposed subject‐wise transfer learning method had increased statistical power for the measurement of longitudinal lesion volume.ConclusionThe proposed method improved lesion segmentation performance and can reduce manual effort to correct the automatic segmentations for final data analysis in longitudinal studies.
Simultaneous mandibular Jaw‐in‐a‐Day and maxillary All‐on‐4 rehabilitation in a single surgery for severe facial trauma: A case report
Authors: Jin Zachary , Jelmini Jonathan J. , Schwitzer David M. , Williams Fayette C. , Hockaday Joshua J. , Kim Roderick Y. 
Published: February 2025

AbstractAdvancements in microvascular free‐flap surgery and virtual surgical planning (VSP, 3D Systems) have allowed significant development in immediate reconstruction and dental rehabilitation of maxillofacial defects. These techniques are commonly utilized for dental rehabilitation of ablative defects of the head and neck affected by pathology. The widespread use of the Jaw‐in‐a‐Day protocol has shown to be a feasible and predictable way to immediately reconstruct and dentally rehabilitate in one surgery. However, the literature on applying these advanced techniques in the trauma setting is limited. Furthermore, there are few reported cases in which a Jaw‐in‐a‐Day protocol is used in conjunction with the full arch dental rehabilitation of the opposing jaw. In this scenario, restoring just one arch would not restore a fully functional occlusion. This case report describes a concomitant mandibular Jaw‐in‐a‐Day with a maxillary All‐on‐4 in one surgery for a patient who sustained severe facial trauma from a self‐inflicted gunshot wound.
Plant Leaf Disease Classification in Precision Farming With Hybrid Classifier: Colour, Deep and Pattern‐Based Feature Descriptors
Authors: Tripathi Mukesh Kumar , Neelakantappa Madugundu , Prashanthi Talla , Sukte Chudaman Devidasrao , Pandurang Deshmukh Dilip , Bhosle Nilesh P. 
Published: February 2025

ABSTRACTIn the agricultural sector, pesticides are used to prevent disease transmission and protect crop yields. However, due to the diverse range of diseases, the human observation can often lead to misidentification. It is essential for a timely and precise disease classification approach without human intervention. Classifying the plant leaf diseases with an automated system is the significant need in this scenario. In this work, a hybrid classification model for the categorisation of plant leaf diseases is presented. Preprocessing, segmentation, feature extraction and classification of leaf diseases are the four steps in this method. In this work, crops such as grapes and mango are considered. Primarily, preprocessing the input image by utilising Gaussian filtering methods, which enhances the quality of image. The filtered image is then put through a segmentation process using the MBIRCH framework. The segmented image is then used to extract a number of features, including GLCM, ILGBHS, colour, shape and deep features using the VGG16 and AlexNet networks. Following the procedure, the hybrid model—which combines Bi‐GRU and DCNN with TL—is applied to the acquired features, and the final classified result is determined by the enhanced fusion score method.
An Assessment of Demersal Elasmobranch Occurrence and Associated Habitats Using an Autonomous Underwater Vehicle (AUV)
Authors: Taylor Jonathon , Howe John A. , Thorburn James , Fox Clive J. , McGonigle Christopher , Rybanska Petra 
Published: February 2025

ABSTRACTTo implement effective management and conservation strategies, an understanding of the spatial ecology, habitat preferences and movement of demersal elasmobranchs is required. This study combines a photographic survey obtained from an autonomous underwater vehicle (AUV) with existing bathymetric data to help understand elasmobranch ecology within the Firth of Lorn, western Scotland. This area is within the Loch Sunart to Sound of Jura Marine Protected Area (MPA) and designated for the protection of the critically endangered flapper skate (Dipturus intermedius). Two areas of seabed were surveyed using an AUV in water depths of 110–165 m southwest of the Isle of Kerrera. Eight surveys were conducted in total, four in each area. Each area was surveyed twice over 2 days in October 2020 and twice in 2 days in May June 2021. One day used bait on the seabed (October) whilst all the others had no bait. For each survey, the AUV travelled 17 km at a height of 2 m above the seabed in a lawnmower pattern providing 0.5 km2 photographic coverage for ~2 h per survey. Five elasmobranch species, two scyliorhinids (Scyliohinus canicula and Galeus melastomus) and three rajiformes (D. intermedius, Raja clavata and Leucoraja naevus), were identified from a total of 43 k seabed photographs. In total 42 individual animals and 7 egg cases were observed. Although the AUV had short survey times and small study areas the results are encouraging for AUVs being a useful tool in understanding elasmobranch ecology.
Guiding medical trainees' workplace learning for interprofessional collaboration—Looking to physicians or seeing nurses?
Authors: Stalmeijer Renée E. , de Grave Willem S. , Smeenk Frank W. J. M. , Varpio Lara 
Published: February 2025

AbstractIntroductionEffective healthcare practice requires interprofessional collaboration (IPC) between all members of the healthcare team. Preparing healthcare trainees for IPC has proven to be difficult. Research suggests that workplace learning has a vital role in acquiring IPC competencies. However, guidance is required for trainees to make optimal use of IPC workplace learning opportunities. This study asks (1) To what extent is guidance provided to medical trainees when learning to collaborate interprofessionally?; and (2) Who provides this guidance and how?MethodsWe conducted a constructivist, qualitative study using iterative cycles of semi‐structured interviews and reflexive thematic analysis. A purposive sample of medical trainees (N = 11), nurses (N = 9), advance practice clinicians (APCs)(N = 3) and attending physicians (N = 9) associated with a department of general internal medicine in a non‐academic teaching hospital participated in this study. Data‐analysis was informed by Billett's concept of guidance.ResultsGuidance on IPC was provided to medical trainees both intraprofessionally and interprofessionaly, be it limited, informal and implicit. Nurses and APCs provided more guidance on IPC than attending physicians. Guidance by attending physicians included implicit modelling and only became explicit in response to concerns raised about trainees' IPC by nurses. Nurses and APCs provided continuous guidance on various aspects of IPC but felt hampered by hierarchical issues to provide feedback. Trainees were more focused on feedback provided by attending physicians than they were aware of nurses' feedback.ConclusionThe potential of workplace learning to learn IPC competencies is currently hampered by a lack of explicit guidance. Optimizing the role of workplace learning in IPC competence development requires more explicit role modelling and collaborative intentionality by attending physicians, more critical reflection by trainees and a strengthening of the feedback role of nurses and APCs.
MmoD and MmoG Are Crucial for the Synthesis of Soluble Methane Monooxygenase in Methanotrophs
Authors: Cheng Minggen , Liu Yongchuang , Yan Xin 
Published: February 2025

ABSTRACTSoluble methane monooxygenase (sMMO) from methanotrophs has been extensively investigated for decades. However, major knowledge gaps persist regarding the synthesis mechanism of sMMO, particularly concerning the ambiguous roles of mmoD and mmoG in the sMMO gene cluster. Here, the functions of mmoD and mmoG were investigated in a model methanotrophic strain, Methylotuvimicrobium buryatense 5GB1C. Both genes were found to be essential for the functional expression of sMMO. Genetic and biochemical data supported the hypothesis that MmoG acts as a folding chaperone for both MmoX and MmoR, while MmoD serves as an assembly chaperone for the hydroxylase component. The functional expression of sMMO in Escherichia coli was achieved in an mmoD‐ and mmoG‐dependent manner. In addition, deletion of mmoD dramatically reduced the transcription of the sMMO cluster in M. buryatense 5GB1C, implying that MmoD may regulate the sMMO cluster via an unknown mechanism. Knockout of neither mmoD nor mmoG abolished the essential feature of “copper switch”, indicating that they do not serve as the initial regulators of “copper switch”. These results demonstrate the crucial roles of mmoD and mmoG in sMMO synthesis and offer new insights into heterologous expression of sMMO.
Association Between Intestinal Diseases and Periodontitis: A Systematic Review and Meta‐Analysis
Authors: Wu Yuebo , Ji Daozhi , Chen Xiaoqiu , Wang Lixin , Ye Fang 
Published: February 2025

ABSTRACTBackgroundDespite evidence suggesting a potential correlation between intestinal diseases such as inflammatory bowel diseases (IBD) and colorectal cancer (CRC) with periodontitis (PD), there is a lack of comprehensive systematic reviews and meta‐analyses to consolidate these findings.MethodsThis study investigates studies published until December 31, 2023, in reputable databases such as PubMed, Embase, Cochrane Library, and Web of Science. The statistical analysis was conducted using Review Manager Version 5.4, calculating odds ratios (OR) and 95% confidence intervals (CI) based on the selected research papers, utilizing a fixed‐effects model.ResultsIt demonstrates a significant increase in the risk of PD among patients with IBD, as indicated by an OR of 2.11 (95% CI: 1.80–2.49). Further analysis revealed elevated risks of PD for both Crohn's disease (CD) and ulcerative colitis (UC), with respective ORs of 1.96 (95% CI: 1.69–2.26) and 2.14 (95% CI: 1.85–2.47). A direct association was observed between CRC and PD, suggesting a 20% higher risk of PD in patients with CRC (OR = 1.20, 95% CI: 1.06–1.36).ConclusionOur meta‐analysis highlights the potential role of PD in managing systemic conditions like IBD and CRC.
Attitude of Undergraduate Dental Students to Oral Mucosal Biopsies From Six European Countries
Authors: Brailo Vlaho , Lončar Brzak Božana , Carey Barbara , Andabak Rogulj Ana , Vidović Juras Danica , Škrinjar Ivana , Freitas Marcio Diniz , Posse Jacobo Limeres , Monteiro Luis , Silva Luis M. , Fricain Jean‐Cristophe , Catros Sylvain , Lodi Giovanni , Lombardi Niccolò , Varoni Elena , Cook Richard , Escudier Michael , Ariyaratnam Raj , Albuquerque Rui 
Published: February 2025

ABSTRACTIntroductionMultiple studies have been undertaken to assess level of knowledge on the topic of oral mucosal biopsies from a general dental practitioner perspective, but only limited data is available on undergraduate dental students' perspective. The aim of this study was to assess clinical experience and attitudes towards oral mucosal biopsies in final‐year undergraduate dental students.Material and MethodsOnline questionnaire was sent to dental students in six European countries (Croatia, France, Italy, Portugal, Spain and United Kingdom). The questionnaire assessed clinical experience, attitudes to oral biopsy, self‐perceived competence, and obstacles for performing a biopsy. Multiple choice questions and 5‐point Likert scale were used.ResultsTwo hundred and ninety‐three students (response rate 24% to 88%) participated in the survey. A small proportion of students (54; 21.7%) performed a biopsy during their undergraduate education, mainly in an oral medicine setting. The majority of students did not consider themselves competent in performing a biopsy. The most common listed obstacle for performing a biopsy was lack of clinical experience with oral mucosal lesions.ConclusionThe results suggest there is a need for more practical training in oral biopsy techniques, as well as a need for increased clinical exposure to different oral mucosal pathologies.
An efficient mRNA delivery system for genome editing in plants
Authors: Qiu Fengti , Xue Chenxiao , Liu Jinxing , Li Boshu , Gao Qiang , Liang Ronghong , Chen Kunling , Gao Caixia 
Published: February 2025

SummaryTransgene‐free genome editing is important for crop improvement as it reduces unanticipated genomic changes. While mRNA delivery systems offer a powerful method for achieving transgene‐free genome editing, they remain inefficient and challenging in plants. Here we describe an efficient mRNA delivery system for plants with substantially improved editing efficiency. By optimizing the 5′ untranslated regions (5′UTRs) and poly(A) tails of in vitro‐transcribed (IVT) mRNAs and coating the mRNA with protamine during particle bombardment, we have developed an optimized mRNA delivery system termed v2_TMV/DEN2. This system enhanced the efficiencies of knock‐out, A‐to‐G and C‐to‐T base editing by an average 4.7‐, 3.4‐ and 2.5‐fold at various endogenous sites compared with plasmid‐based transient delivery system via particle bombardment in rice suspension cells and wheat immature embryos 48 h post‐transformation. Furthermore, we obtained edited plants with efficiencies of 5.0–180.8% and 26.1–26.2% using v2_TMV/DEN2 in rice and wheat, respectively, compared with 0.0–43.2% and 4.7–10.4% using plasmids. Our study provides a convenient and efficient mRNA delivery system for transgene‐free genome editing in plants.
Evaluating the Cutaneous Manifestations and Associated Comorbidities of Childhood Obesity
Authors: Epstein Samantha , Shah Sonal D. 
Published: February 2025

ABSTRACTRates of childhood obesity are rising, making it a public health concern due to its link to numerous poor health outcomes over the lifespan. In adults, obesity is associated with various inflammatory skin conditions; however, this is not well‐studied in children with obesity. A retrospective cohort study was conducted using the TrinetX Research Network Database, evaluating children under 18 with and without obesity and various dermatologic conditions and comorbidities. Childhood obesity was associated with increased rates of all dermatologic conditions and associated comorbidities evaluated (p < 0.05). This study highlights associations between various dermatologic conditions and comorbidities in children with obesity, compared with those without, emphasizing the need for early intervention and management strategies to mitigate obesity related health complications in pediatric populations.
A Phase 1, Open‐Label Study of the Pharmacokinetics of Ritlecitinib in Children Aged 6–12 Years With Alopecia Areata
Authors: Gonzalez Mercedes E. , Browning John , Smith Stacy , Plotka Anna , Zhu Jing “Daisy” , Parvatini Shyam , Huh Yeamin , Wolk Robert 
Published: February 2025

ABSTRACTBackgroundAlopecia areata (AA) is an autoimmune disease characterized by hair loss that can negatively impact quality of life. AA has a significant pediatric prevalence; however, no systemic treatments are approved for AA in patients aged < 12 years. Ritlecitinib, a JAK3/TEC family kinase inhibitor, is approved to treat adults and adolescents with severe AA aged ≥ 12 years. This study evaluated ritlecitinib pharmacokinetic (PK) parameters and safety in pediatric patients with AA aged 6 to < 12 years.MethodsIn this single‐group, uncontrolled, open‐label study, participants received ritlecitinib 20 mg once daily for 7 days. PK parameters of ritlecitinib on Day 7 were measured and summarized descriptively. Safety outcomes, including incidence of adverse events (AEs), were evaluated.ResultsFifteen participants were enrolled and 14 (93.3%) completed the study. The median time to maximum concentration (Tmax) for plasma concentrations of ritlecitinib on Day 7 was ~0.5 h. The mean half‐life of ritlecitinib was ~1.19 h. Geometric means (% coefficient of variation) for area under the curve from 0 to 24 h (AUC24) and maximum concentration (Cmax) were 437.5 ng·h/mL (30%) and 208.7 ng/mL (38%), respectively. Four AEs were experienced by 3 participants, with 1 AE of urticaria resulting in permanent discontinuation. No severe AEs, serious AEs, or clinically meaningful laboratory abnormalities were reported.ConclusionsRitlecitinib PK parameters in pediatric patients were successfully characterized in the present study. Ritlecitinib 20 mg once daily was generally well tolerated in pediatric patients with AA.Trial RegistrationNCT05650333
Clubroot Disease in South Asia: Distribution and Management Practices
Authors: Ghimire Ashish , Devkota Shilpa , Sarkar Ananya , Mittapelly Priyanka , Adhikary Dinesh 
Published: February 2025

ABSTRACTClubroot, caused by the biotrophic protist Plasmodiophora brassicae, is a devastating root disease that affects all members of the Brassicaceae family. Significant progress has been made in understanding its occurrence, life cycle and management strategies. This disease has posed a considerable threat to producers and breeders globally, including South Asia. The disease has been reported in India, Nepal and parts of Bangladesh, Bhutan, Pakistan and Sri Lanka. The cool and moist climatic conditions in the northern Himalayan belt, combined with acidic soils and inadequate disease management systems, are key factors, particularly in areas of India and Nepal prone to clubroot outbreaks. Disease management strategies currently focus on soil amendments, the use of synthetic fungicides and fumigants and the application of resistant genotypes. However, limited research has been conducted on modes of disease transmission. Recent studies revealed that contaminated soil and infected seedlings are major contributors to the spread of the pathogen. Brassica crops such as B. juncea (mustard), B. napus (canola) and B. oleracea (cabbage) are particularly vulnerable. However, resistant cultivars like B. napus ‘Midas’ and B. oleracea ‘Big Sun 111’, ‘Nepa Star’ and ‘Kathmandu Local’, have been identified in India and Nepal, offering some potential for mitigating the disease. To combat clubroot effectively, there is an urgent need for integrated disease management strategies and the development of resistant genetic materials. These efforts should involve diverse stakeholders, including producers, industries, government sectors and academicians, aiming to advance the understanding of clubroot challenges and bridging critical research in South Asia.