bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radiation‐induced graft copolymerization of methylmethacrylate onto poly(tetrafluoroethylene‐co‐ethylene) film
Authors: Kaur Inderjeet , Vibha Sharma  , Gupta Nirupam 
Published: November 2008

AbstractModification of poly(tetrafluoroethylene‐co‐ethylene), Tefzel (ETFE), film has been carried out by grafting methylmethacrylate (MMA) by radiation method including preirradiation and double‐irradiation methods. Percentage of grafting has been determined as a function of the (i) total dose, (ii) monomer concentration, (iii) amount of liquor ratio, (iv) reaction time, and (v) temperature.The effect of different alcohols such as methanol, ethanol, 2‐propanol, n‐butanol, n‐pentanol, and 2‐ethoxy ethanol on percentage of grafting of MMA was also studied. The graft copolymers were characterized by IR spectroscopy and thermogravimetric analysis (TGA). Methylmethacrylate produces higher percentage of grafting by preirradiaton method than double‐irradiation method. MMA‐grafted ETFE films (Sirr), i.e., prepared by preirradiation involving single irradiation show better thermal stability than MMA‐grafted ETFE films (Dirr), i.e., prepared by double irradiation and unmodified ETFE film. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2009
Proteomics in South Africa: Current status, challenges and prospects
Authors: Ndimba Bongani K. , Thomas Ludivine A. 
Published: November 2008

AbstractProteomics is a biotechnology research area that is generally defined as the large‐scale study of protein expression, structure and functions. Primarily, proteomics is used to study relative cellular, subcellular and extracellular abundances of proteins expressed at a defined physiological state on a large scale. In contrast to the analysis of mRNA expression studies, generally referred to as transcriptomics, proteomics approaches take into consideration the post‐transcriptional, translational and post‐translational modifications of polypeptides. Over the past 10 years, the proteomics field has been growing tremendously and contributing positively to biotechnology, particularly in North America, Europe and Asia. Research output in Africa is still very low in comparison. This article reviews proteomics capacity as well as research activities in South Africa. We highlight, with examples, the potential that this technology has in the acceleration of disease biomarker discovery and its role in drug design. Our ultimate objective is to promote further developments, research and applications of proteomics in South Africa, aiming for the generation of new scientific knowledge for our continent and for the rest of the world.
Tubulin Photoaffinity Labeling with Biotin‐Tagged Derivatives of Potent Diketopiperazine Antimicrotubule Agents
Authors: Yamazaki Yuri , Kohno Kyoko , Yasui Hiroyuki , Kiso Yoshiaki , Akamatsu Miki , Nicholson Benjamin , Deyanat‐Yazdi Gordafaried , Neuteboom Saskia , Potts Barbara , Lloyd G. Kenneth , Hayashi Yoshio 
Published: November 2008

AbstractNPI‐2358 (1) is a potent antimicrotubule agent that was developed from a natural diketopiperazine, phenylahistin, which is currently in Phase I clinical trials as an anticancer drug. To understand the precise recognition mechanism of tubulin by this agent, we focused on its potent derivative, KPU‐244 (2), which has been modified with a photoreactive benzophenone structure, and biotin‐tagged KPU‐244 derivatives (3 and 4), which were designed and synthesized for tubulin photoaffinity labeling. Introduction of the biotin structure at the p′‐position of the benzophenone ring in 2 exhibited reduced, but significant biological activities with tubulin binding, tubulin depolymerization and cytotoxicity in comparison to the parent KPU‐244. Therefore, tubulin photoaffinity labeling studies of biotin‐derivatives 3 and 4 were performed by using Western blotting analysis after photoirradiation with 365 nm UV light. The results indicated that tubulin was covalently labeled by these biotin‐tagged photoprobes. The labeling of compound 4 was competitively inhibited by the addition of diketopiperazine 1 or colchicine, and weakly inhibited by the addition of vinblastine. The results suggest that photoaffinity probe 4 specifically recognizes tubulin at the same binding site as anticancer drug candidate 1, and this leads to the disruption of microtubules. Probe 4 serves well as a useful chemical probe for potent antimicrotubule diketopiperazines, much like phenylahistin, and it also competes for the colchicine‐binding site.
Driving Force Analysis of Proton Tunnelling Across a Reactivity Series for an Enzyme‐Substrate Complex
Authors: Hothi Parvinder , Hay Sam , Roujeinikova Anna , Sutcliffe Michael J. , Lee Michael , Leys David , Cullis Paul M. , Scrutton Nigel S. 
Published: November 2008

AbstractQuantitative structure‐activity relationships are widely used to probe CH bond breakage by quinoprotein enzymes.[1–4] However, we showed recently that p‐substituted benzylamines are poor reactivity probes for the quinoprotein aromatic amine dehydrogenase (AADH) because of a requirement for structural change in the enzyme‐substrate complex prior to CH bond breakage.[5] This rearrangement is partially rate limiting, which leads to deflated kinetic isotope effects for p‐substituted benzylamines. Here we report reactivity (driving force) studies of AADH with p‐substituted phenylethylamines for which the kinetic isotope effect (∼16) accompanying CH/C2H bond breakage is elevated above the semi‐classical limit. We show bond breakage occurs by quantum tunnelling and that within the context of the environmentally coupled framework for H‐tunnelling the presence of the p‐substituent places greater demand on the apparent need for fast promoting motions. The crystal structure of AADH soaked with phenylethylamine or methoxyphenylethylamine indicates that the structural change identified with p‐substituted benzylamines should not limit the reaction with p‐substituted phenylethylamines. This is consistent with the elevated kinetic isotope effects measured with p‐substituted phenylethylamines. We find a good correlation in the rate constant for proton transfer with bond dissociation energy for the reactive CH bond, consistent with a rate that is limited by a Marcus‐like tunnelling mechanism. As the driving force becomes larger, the rate of proton transfer increases while the Marcus activation energy becomes smaller. This is the first experimental report of the driving force perturbation of H‐tunnelling in enzymes using a series of related substrates. Our study provides further support for proton tunnelling in AADH.
Stenting with PRotruding strut INTo side branch (SPRINT) technique: A novel technique for coronary bifurcation stenting
Authors: Habara Maoto , Kinoshita Yoshihisa 
Published: November 2008

AbstractA number of stenting techniques have been proposed for optimal treatment of bifurcation lesions. However, the most ideal interventional strategies have yet to be discovered. In bifurcation treatment, procedural complexity and high restenosis rate remain as major obstacles to successful treatment. To resolve these problems, we developed a new technique for bifurcation stenting called Stenting with PRotruding strut INTo side branch (SPRINT). This technique would completely cover the carina with a relatively simple procedure. A novel technique of coronary bifurcation stenting is reported. Here, we report on two successful cases using this novel technique. © 2009 Wiley‐Liss, Inc.
Preferential Formation of Homochiral Helical Sandwich‐Shaped Architectures through the Metal‐Mediated Assembly of Tris(imidazoline) Ligands with a Set of d3–d10 Transition‐Metal Ions
Authors: Yan Liwei , Wang Zhen , Chen Ming‐Tsz , Wu Ningjie , Lan Jingbo , Gao Xin , You Jingsong , Gau Han‐Mou , Chen Chi‐Tien 
Published: November 2008

AbstractA novel type of chiral tris‐monodentate imidazolinyl ligands ((S,S,S)‐4 and (R,R,R)‐4) has been achieved in good yields. The ligands show a strong tendency to induce the generation of the discrete sandwich‐shaped M3L2 architectures with programmed helicity through the edge‐directed complexation with a series of d3–d10 transition‐metal ions, while taking advantage of the steric hindrance of the bulky substituents of the imidazoline rings to avoid the formation of extended metal–organic frameworks (MOFs). In spite of different coordination geometries, monovalent metal ions (e.g. Ag+), divalent metal ions (e.g. Pd2+, Cu2+, Cd2+, Zn2+, Co2+, Mn2+, and Ni2+), and even trivalent metal ions (e.g. Fe3+ and Cr3+) exhibit isostructural coordination. Installation of stereocenters fused onto the imidazoline rings results in favored handedness of the self‐assemblies through the expression of molecular chirality into supramolecular helicity. In the crystal structures of [M3{(S,S,S)‐4}2], the self‐assembly has to adopt the M form to relax the van der Waals repulsions of the phenyl and isopropyl groups. The replacement of (S,S,S)‐4 with (R,R,R)‐4 exclusively affords the opposite helicity (P). These results should provide important insights for the design of chiral helical capsule‐like assemblies.
Development, Scope and Mechanisms of Multicomponent Reactions of Asymmetric Electron‐Deficient Alkynes with Amines and Formaldehyde
Authors: Cao Hua , Wang Xiujun , Jiang Huanfeng , Zhu Qiuhua , Zhang Min , Liu Haiyang 
Published: November 2008

AbstractBased on the reactive behaviour of the substrates, two synthetic routes to polysubstituted pyrimidine derivatives are presented herein: 1) A catalyst‐free multicomponent reaction of electron‐deficient alkynes, aliphatic amines and formaldehyde and 2) AgI‐catalyzed synthesis of pyrimidines from electron‐deficient alkynes, anilines and formaldehyde by a domino reaction. Under optimized conditions, the multicomponent reactions were accomplished with high regioselectivity and excellent yields. A computational study was carried out by using the B3LYP density functional theory to elucidate the mechanisms of the catalyst‐free hydroamination reaction. Calculations showed the activation free energies of aliphatic amines were lower than those of anilines, which is consistent with the experimental results.
ChemInform Abstract: Sr, Ba and Cd Arsenates with the Apatite‐Type Structure.
Authors: Dordevic Tamara , Sutovic Sabina , Stojanovic Jovica , Karanovic Ljiljana 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Al‐Rich Region of Al—Pd—Ru at 1000 to 1100 °C.
Authors: Pavlyuchkov D. , Grushko B. , Velikanova T. Ya. 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Characterization of a New Quaternary Selenide Sr3GeSb2Se8.
Authors: Yu Ching‐Yi , Wang Ming‐Fang , Chung Ming‐Yang , Jang Shyue‐Ming , Huang Jih‐Chen , Lee Chi‐Shen 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Stepwise Palladium‐Catalyzed 1,4‐Addition of Arylboronic Acids to Enones and Regioselective Baeyer—Villiger Oxidation for Enantioselective Synthesis of β‐Diaryl Esters and (+)‐(R)‐Tolterodine.
Authors: Kobayashi Kenya , Nishikata Takashi , Yamamoto Yasunori , Miyaura Norio 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Rhodium‐Catalyzed Enantio‐ and Diastereoselective Intramolecular [2 + 2 + 2] Cycloaddition of Unsymmetrical Dienynes.
Authors: Sagae Hiromi , Noguchi Keiichi , Hirano Masao , Tanaka Ken 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Pronounced Steric Effects of Substituents in the Nazarov Cyclization of Aryl Dienyl Ketones.
Authors: Marcus Andrew P. , Lee Amy S. , Davis Rebecca L. , Tantillo Dean J. , Sarpong Richmond 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: An Efficient Procedure for the TEMPO‐Catalyzed Oxidation of Alcohols to Aldehydes and Ketones Using Ferric Chloride Hexahydrate as Terminal Oxidant.
Authors: Kumar R. Senthil , Karthikeyan K. , Perumal Paramasivan T. 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Activation of Organozinc Reagents with t‐Bu‐P4 Base for Transition Metal‐Free Catalytic SN2′ Reaction.
Authors: Kobayashi Koji , Ueno Masahiro , Naka Hiroshi , Kondo Yoshinori 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Control of Four Stereocenters in an Organocatalytic Domino Double Michael Reaction: Efficient Synthesis of Multisubstituted Cyclopentanes.
Authors: Tan Bin , Shi Zugui , Chua Pei Juan , Zhong Guofu 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Enantioselective Synthesis of β‐Aryl‐γ‐amino Acid Derivatives via Cu‐Catalyzed Asymmetric 1,4‐Reductions of γ‐Phthalimido‐Substituted α,β‐Unsaturated Carboxylic Acid Esters
Authors: Deng Jun , Hu Xiang‐Ping , Huang Jia‐Di , Yu Sai‐Bo , Wang Dao‐Yong , Duan Zheng‐Chao , Zheng Zhuo 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Novel Pyridine‐Bridged Bis‐benzimidazolylidene Pincer Palladium Complex: Synthesis and Catalytic Properties.
Authors: Tu Tao , Malineni Jagadeesh , Doetz Karl Heinz 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Single‐Isomer Trisubstituted Olefins from a Novel Reaction of (E)‐β‐Chloro‐α‐iodo‐α,β‐unsaturated Esters and Amides.
Authors: Simard‐Mercier Julie , Jiang Jojo Liu , Ho Michael L. , Flynn Alison B. , Ogilvie William W. 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Chiral Iron‐Sexipyridine Complex as a Catalyst for Alkene Epoxidation with Hydrogen Peroxide.
Authors: Yeung Ho‐Lun , Sham Kiu‐Chor , Tsang Chui‐Shan , Lau Tai‐Chu , Kwong Hoi‐Lun 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: 2,6‐Diazaspiro[3.3]heptanes: Synthesis and Application in Pd‐Catalyzed Aryl Amination Reactions.
Authors: Burkhard Johannes , Carreira Erick M. 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Entry to Heterocycles Based on Indium‐Catalyzed Conia‐Ene Reactions: Asymmetric Synthesis of (‐)‐Salinosporamide A.
Authors: Takahashi Keisuke , Midori Michiko , Kawano Kei , Ishihara Jun , Hatakeyama Susumi 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Unexpected Formation of New Bicyclic γ‐Lactams by Dimerization of α‐Chloroacetoacetanilides.
Authors: Han Minsoo , Nam Kee‐Dal , Hahn Hoh‐Gyu , Shin Dongyun 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Tandem Alkylation/Ester Hydrolysis Using Polymer‐Supported Hydroxide for Catch and Release Isolation of a Series of Benzoimidazolonecarboxylic Acids.
Authors: Welzel Morgan , Morwick Tina M. 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Versatile Synthesis of 2,4‐Substituted Oxazoles.
Authors: Chudasama Vijay , Wilden Jonathan D. 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A New One‐Pot Synthetic Approach to the Highly Functionalized (Z)‐2‐(Buta‐1,3‐dienyl)phenols and 2‐Methyl‐2H‐chromenes: Use of Amine, Ruthenium and Base‐Catalysis.
Authors: Ramachary Dhevalapally B. , Narayana Vidadala V. , Ramakumar Kinthada 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: New Approaches to the Synthesis of Pyridinium N‐Heteroarylaminides.
Authors: Cordoba Marta , Izquierdo M. Luisa , Alvarez‐Builla Julio 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Cardenolides from Antiaris toxicaria as Potent Selective Nur77 Modulators.
Authors: Jiang Miao‐Miao , Dai Yi , Gao Hao , Zhang Xue , Wang Guang‐Hui , He Jia‐You , Hu Qiong‐Ying , Zeng Jin‐Zhang , Zhang Xiao‐Kun , Yao Xin‐Sheng 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Highly Oxygenated Lanostane Triterpenoids from the Fungus Ganoderma applanatum.
Authors: Wang Fei , Liu Ji‐Kai 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Pyranoid and Furanoid Glycals from Glycosyl Sulfoxides by Treatment with Organolithium Reagents.
Authors: Gomez Ana M. , Casillas Marta , Barrio Aitor , Gawel Anna , Lopez J. Cristobal 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: An Improved Direct Synthetic Approach to Anhydronucleosides (II).
Authors: Al‐Juwaiser Ibtehal A. , Ibrahim Maher R. , Al‐Awadi Nouria A. , Ibrahim Yehia A. 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Facile Biogenetic Synthesis of Pulcheotine A.
Authors: Wakchaure Prasad B. , Argade Narshinha P. 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.