bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study of Influence of Product Range on Production Capacity Indicators of Precast Construction Plants
Authors: Gurinovich V. Yu 
Published: April 2024

The paper presents the results of research of the influence of product range parameters on the indicators of development of the design capacities of precast construction plants. The quantity and concrete consumption of products in terms of 1 m2 of total area, as well as the circulation of products, have been taken as the analyzed parameters of product range. It is noted that calculations of production capacity and basic technical and economic indicators of production at the stage of technological design are based on the product range of a typical block section of a house series. At the same time, architectural individuality, flexibility of planning and design solutions of prefabricated houses buildings in industrial design require a variety of modifications of block sections, which is inextricably linked with the growth of the range of manufactured products. Expansion of the range of products for modifications of block sections in the production program of plants is an objective regularity that should be taken into account in the technological design of new or reconstruction of existing precast constructions plants and planning production programs for housing construction. Significant fluctuations in the parameters of the product range in the production programs of plants have been recorded. A regression analysis of the parameters of the range products of production programs of precast construction plants has been carried out. The dependence of product range on the share of dotted houses in housing construction programs has been established. The main parameters of houses determining fluctuations in the range of products have been identified, which include the number of storeys and the number of sections in the house configuration. Taking into account the fact of the significant influence of the product range on the production capacity of plants, the dependence of the indicator of compliance of the concrete capacity of products with 1 m2 of total area on the production capacity indicators has been established. The reliability of the obtained mathematical models is confirmed by the results of statistical processing of research results and verification of models in calculations of the current production capacity of plants.
Road Safety Concept in the Republic of Belarus
Authors: Kapski D. V. , Bogdanovich S. V. , Kot E. N. , Khmelnitskaya L. V. 
Published: April 2024

The general trend of accident rate reduction, which has been observed in the Republic of Belarus since 2010, reversed in 2017–2018. Remaining within the framework of the country’s traditional engineering activities related to road maintenance is unlikely to significantly improve road safety. A transition to qualitatively new practices and mechanisms for ensuring road safety is required. In order to implement this transition, a second Road Safety Concept has been developed. The Concept is based on the Safe System approach, which offers the implementation of measures in four areas: improving road infrastructure safety, increasing vehicle safety, ensuring safe speeds, and training safe road users. The main threat to the implementation of the Safe System approach in the Republic of Belarus is the fixation of stakeholders on their narrow corporate interests and the unwillingness to take into account nation-wide road safety. The Concept mainly focuses on the “Safe Road Infrastructure” component. A transition to sustainable road safety and the introduction of a Forgiving Road approach are included in the Concept. The introduction of assessment of infrastructure projects impact on traffic safety, traffic safety audit and inspections, road traffic risk assessment, and elimination of accident hotspots are also specified. The introduction of road safety audit is considered an important milestone in the transition to the Forgiving Road approach. The development of Intelligent Transportation Systems is included for the same purpose. Despite the fact that the Concept sets reasonably realistic goals, there are certain concerns about the feasibility of their achievement. This is due to significant institutional problems, such as the lack of a single coordinating body and the complexity of interdepartmental interaction.
The incidence of acute exacerbation of idiopathic pulmonary fibrosis: A systematic review and meta-analysis
Authors: wang yan , Ji Zile , Xu Baichuan , Li Suyun , Xie Yang 
Published: April 2024

Abstract

Background: Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease with a high incidence of acute exacerbation and an increasing mortality rate. Currently, treatment methods and effects are limited. Therefore, we conducted a meta-analysis of the incidence of acute exacerbation in patients with IPF, hoping to provide reference for the prevention and management of IPF.
Methods: We systematically searched the PubMed, Embase, Cochrane Library and Web of Science databases. From the creation of the database to the cohort study on April 3, 2023, we collected studies on the incidence of acute exacerbation of IPF patients, and used Stata software (version 16.0) for meta analysis. We used the Newcastle Ottawa Quality Assessment Scale (NOS) to assess the risk of bias for each study. We calculated the incidence of acute exacerbation in IPF patients and analyzed the risk and prognostic factors for acute exacerbation in IPF patients.
Results: A total of ten cohort studys on the incidence of AE-IPF were included, including 11855 IPF patients. The results showed that the incidence of acute exacerbation within one year was 9%; the incidence of acute exacerbation within 2 years is 13%; the incidence of acute exacerbation within 3 years is 19%; the incidence of acute exacerbation within 4 years is 11%. In addition, one study reported an acute exacerbation rate of 1.9% within 30 days. The incidence of acute exacerbation within ten years reported in one study was 9.8%. One study included a retrospective cohort study and a prospective cohort study. In this study, the prospective cohort study showed that the incidence of acute exacerbation within 3 years was 18.6%, similar to the results of the retrospective cohort study meta-analysis.
Conclusions: Our system evaluation and meta-analysis results show that the incidence of AE-IPF is relatively high. Therefore, sufficient attention should be paid to the research results, including the management and prevention of the disease, in order to reduce the risk of AE.
Systematic review registration: PROSPERO, identifier CRD42022341323.
WITHDRAWN: Optimization and characterization of biochar obtained from weedy biomass of Calotropis gigantea by vacuum pyrolysis
Authors: Poonia Poonam , Gaur Loveena , Panwar Narayan Lal 
Published: April 2024

Abstract
The full text of this preprint has been withdrawn by the authors due to author disagreement with the posting of the preprint. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
Do Preventive Programmes Reduce the Need for New Sedation for the Treatment of Oral Pathology?
Authors: Ríos Inmaculada Gómez , Muñoz Clara Serna , Silva Amparo Pérez , Beneyto Yolanda Martínez , Ruiz Antonio José Ortiz 
Published: April 2024

Abstract

Objetives: To analyse the need for re-interventions under deep sedation to treat new oral pathology in a population of healthy children and SHCN who followed a prevention programme during follow-up and to study the influence of parental motivation and child collaboration on the need for re-interventions under deep sedation.
Material and methods: A cross-sectional study was carried out in a private clinic in Cartagena (Murcia, Spain), with patients treated under deep sedation from 2006 to 2018, both years included, following the Strobe statement.
Results: In this study with 230 patients, 63.05% were referred for deep sedation due to inadequate behavior management in the dental chair. Most patients were between 4 and 9 years old. High rates of dental caries and pulpal pathology were observed, with 47.40% of patients being healthy and 52.60% having special needs. Parental cooperation and participation in preventive programs reduced the need for additional sedation, especially in "cooperative" children, highlighting significant improvements in their awake dental treatment.
Conclusions: Prevention programmes, including motivational interviewing, are essential to improve children's behaviour in the dental chair and reduce the need for re-interventions under general anaesthesia or deep sedation.
Clinical Relevance: Although patients with special needs do require more sedation during their lifetime due to their inability to cooperate, these programmes are necessary for the maintenance of oral health status and for the early diagnosis of caries lesions.
Evidence of a cascading positive tipping point towards electric vehicles
Authors: Mercure Jean-Francois , Lam Aileen , Buxton Joshua , Boulton Chris , Lenton Timothy 
Published: April 2024

Abstract

Electric vehicles (EVs) can reduce road transport emissions and have recently seen rapid innovation, decline in cost and a rise in popularity.1–7 Past a tipping point where uptake becomes self-propelling, EVs could irreversibly replace internal combustion engine vehicles (ICEVs), as industry discontinues conventional production chains.8–10 Here we provide evidence that this tipping point likely lies within the next few years in lead markets of the EU and China, and potentially the US, which could spill out into peripheral vehicle markets across the rest of the world. We use a comprehensive dataset over the composition of car sales between 2016 and 2022, tracking 2452 models in 33 countries. The historical evidence shows a sudden decline in conventional vehicle sales starting in 2019 concurrent to a rapid rise in sales of EVs. Critically, the variance and lag-1 autocorrelation of fluctuations in ICEV sales have increased, indicating a loss of resilience of the incumbent technology consistent with the approach to a tipping point. Activating tipping points does not necessarily achieve a sufficiently rapid transition to meet emissions targets. We use simulations of technology evolution to identify timescales for cost-parity and policy frameworks that could accelerate the transition to largely eliminate ICEVs before 2050.
The ammonite faunas of the upper Hypselocyclum to Divisum zones (Lower Kimmeridgian, Upper Jurassic) at Małogoszcz, Holy Cross Mts., central Poland: their stratigraphical interpretation and evolutionary development
Authors: Wierzbowski Andrzej 
Published: April 2024

Abstract

The transgressive succession of deposits of the late Early Kimmeridgian at Małogoszcz in the south-western margin of the Holy Cross Mts. in central Poland yielded diversified faunas of ammonites. The commonly represented Submediterranean ataxioceratid ammonites include the last members of Ataxioceras in the Hypselocyclum Zone and the assemblage of various Crussoliceras, Garnierisphinctes and Progeronia, mostly developed in the Divisum Zone, and associated upwards (Uhlandi Subzone) with aspidoceratids (Pseudhimalayites). A few typical Mediterranean ammonites (Nebrodites, Presimoceras, Idoceras, Taramelliceras) are indicative of the Herbichi Zone. The Subboreal ammonites include mostly Eurasenia, Involuticeras in addition to some Rasenia and Rasenioides of the uppermost Cymodoce Zone, corresponding to the Askepta Subzone. The changes in composition of ammonite faunas and comparison with the coeval faunas of other areas of Europe give indications on the evolutionary development of some Ataxiocertidae and Aulacostephanidae at the end of Early Kimmeridgian. The development of the Crussoliceras, Garnierisphinctes and Progeronia, having possibly their roots in the Mediterranean areas, was strictly correlated with the overall transgression and oscillations of sea-level controlled possibly by climatic eccentricity cycles in northern Tethyan shelf. This resulted also in decline of older Ataxioceras and its nearby allies. The indigenous lineage of Aulacostephanidae includes the transition from Eurasenia to Pararasenia. The development from Rasenioides to Aulacostephanoides occurred mostly in the Subboreal areas – although some late representatives of Rasenioides like R. moeschi reached the area of study. The existence of an independent lineage leading from Rasenia involuta to heavily-ribbed Aulacostephanoides/Aulacostephanus is also suggested.
High prevalence of multidrug resistant and extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae isolated from urinary tract infections in West region, Cameroon.
Authors: Bayaba Solomon , Founou Raspail Carrel , Tchouangueu Flaurant Thibau , Dimani Brice Davy , Mafo Lethicia Danaëlle , Nkengkana Omer Aurelle , Founou Luria Leslie , Noubom Michel 
Published: April 2024

Abstract

Background Antimicrobial resistance remains a worldwide health problem with serious societal and economical repercussions. Multidrug resistant and Extended-Spectrum β-Lactamase producing-Enterobacterales (ESBL-E) are pathogens of critical public health priority that urgently require the research and development of new drugs. This study aims to determine the prevalence and assess the genes conferring resistance to β-lactams among Escherichia coli and Klebsiella pneumoniae isolated from patients with urinary tract infections (UTIs) in the West region, Cameroon.Methods A cross-sectional study was conducted among two healthcare facilities during a four-month period from February to May, 2023. All mid-stream urine samples were collected from UTIs patients. The Escherichia coli and K. pneumoniae strains were identified using Enterosystem 18R kit following the manufacturer instructions. The antimicrobial susceptibility test (AST) was performed using the Kirby-Bauer disk diffusion method. The screening of ESBL production was done using ESBL ChromAgar medium combined with the double-disk synergy test (DDT). Antimicrobial resistance genes were detected using polymerase chain methods. The data analysis was performed using Excel 2016 and IBM SPSS version 20.Results A total of 215 urine samples were collected and analyzed during the study period. A 31.62% (68/215) prevalence of Enterobacterales was detected with prevalence of 79.41% (54/68) and 14.70% (10/68) for Escherichia coli and Klebsiella pneumoniae respectively. The overall prevalence of ESBL-Enterobacterales was 64.70% (44/68). About 82% (36/44) of isolates were MDR and high antimicrobial resistance was observed for amoxicillin + clavulanic acid and ceftazidime. The resistance genes detected were blaCTX−M, blaTEM, tet(B) and tet(A), respectively.Conclusion The findings of this study highlight the high burden of MDR and ESBL-E. coli and K. pneumoniae isolates from UTIs. The study emphasizes the necessity of routine screening and monitoring of antimicrobial resistance in healthcare facilities and community settings. It is critical to implement antimicrobial stewardship programs in the country and infection prevention and control (IPC) measures in hospital settings.
Mathematical modeling of the progression of Duchenne Muscular Dystrophy in San Diego in an era of allele specific oligonucleotide therapy
Authors: Kingsmore Stephen , Baun Dominic , Tobin Laura , Nguyen Hung , Arenchild Madison , Juarez Edwin , kiernan elizabeth , Lesser Daniel , Wong Emily , Prilutsky Daria , Zach Neta , Han Steve , Diogo Dorothee , Szalma Sandor , Laverty Chamindra 
Published: April 2024

Abstract
Duchenne muscular dystrophy (DMD) is a relatively common, severe, progressive, X-linked muscle disorder caused by pathogenic variation in the dystrophin gene. Affected status can be determined at birth, 3-5 years before symptom onset. As effective corticosteroid and genetic therapies are becoming available for DMD, predictive models of DMD progression are needed to guide individualized care of patients and clinical trials of new treatments. We developed a multivariable, dynamical model of DMD progression, as measured by percent of predicted FVC (FVC%), through a longitudinal natural history study of 113 boys from a single center in San Diego County between 2008 – 2023. A mixed effect linear regression model of FVC% had marginal and conditional r2 values of 0.54 and y of 0.83 with five factors (Hispanic ethnicity, B= -10.0, 95% CI -16.2 to -3.89, p=.002; age at symptom onset, B= -2.4, 95% CI -3.6 to -1.3; p<.001; DMD exon 44 skip amenability, B= 13.14, 95% CI 4.0 to 22.31, p=.007; steroid therapy start <10 years, B=24.9, 95% CI 16.0 to 33.9, p<.001; years from symptom onset, B= -2.5, 95% CI -2.9 to -2.2, p<.001). Race, age when first seen at a tertiary referral center, age at molecular diagnosis and treatment with allele specific oligonucleotides were not significantly associated with respiratory progression of DMD as measured by longitudinal predicted forced vital capacity. This model of DMD respiratory progression suggests that care be individualized by earlier or more intensive treatment in Hispanic patients and those with early onset of symptoms. Clinical trials of new treatments for DMD that use FVC% as a primary or secondary end-point may benefit from designs that account for potentially confounding effects of ethnicity, DMD genotype, concurrent use of corticosteroids, and earlier age of onset of symptoms.
Preoperative carbohydrate loading reduces length of hospital stay compared to fasting in patients undergoing major elective, non-cardiac surgery: A systematic Review and Meta- Analysis
Authors: Sebestyén Anna Réka , Szemere Ambrus , Virág Marcell , Ocskay Klementina , Dembrovszky Fanni , Engh Marie Anne , Szabó László , Turan Caner , Hegyi Péter , Molnár Zsolt 
Published: April 2024

Abstract
Introduction
Preoperative fasting is a worldwide routine even though the most recent Enhanced Recovery After Surgery (ERAS) Guidelines recommend preoperative carbohydrate loading instead of fasting, but with low quality of evidence. Our aim was to compare the effects of preoperative carbohydrate loading to fasting and placebo in patients undergoing elective major non-cardiac surgery under general anaesthesia.
Methods
Our systematic search was conducted on 15th of October 2021 in five databases, Medline, Embase, Central, Web of Science and Scopus. We included randomized controlled trials that compared the carbohydrate loading (CHO-group) with fasting (Fasting-group) and with placebo (Placebo-group). Main outcomes were length of hospital stay (LOS), postoperative glucose levels on postoperative day 1 and 2, postoperative insulin levels on postoperative day 1, and C-reactive protein (CRP) levels on postoperative day 1.
Results
Our search revealed 55 eligible articles for the data extraction. LOS was almost two days shorter in the CHO-group as compared to the Fasting-group (MD: -1,71 [95% CI: -3.04, -0,38] days), but there was no significant result when compared to the Placebo-group (-0.01 [-0.16; 0.16]). There were no significant differences between the CHO-group and Fasting-group and CHO-group and Placebo-group regarding the postoperative glucose, insulin and CRP levels.
Conclusion
This meta-analysis found that preoperative CHO-loading as compared to preoperative fasting shortened the length of hospital stay in patients undergoing major elective, non-cardiac surgery. Although several details are still to be unveiled, these data provide further support that preoperative fluid intake with CHO-loading could be beneficial in this patient population.
Optimization study of single point incremental forming process of low carbon steel/CP-Titanium bimetallic sheets using grey relational analysis and response surface methodology
Authors: Abdelkader Wifak Ben , HMIDA RAMZI BEN , Sbayti Manel , Bahloul Riadh 
Published: April 2024

Abstract

Single-point incremental forming (SPIF) of bilayer sheets is an inventive manufacturing technique. The formability and deformation behavior of an incrementally formed composite sheet are not sufficiently explored. In this paper, the incremental forming of CP-titanium/low-carbon steel bimetallic sheets are studied both experimentally and numerically. The results demonstrated that the deformation mechanisms are different from the deformation behavior of a monolithic metal sheet. The inner layer is deformed according to the layer in contact with the numerically controlled punch. In addition, the study reveals that the layer arrangement strongly influences the process. The grey relational analysis (GRA) and the global approach based on response surface methodology (RSM) are used to optimize the process parameters, namely the total initial sheet thickness of all the considered layers, the wall-drawing angle, and the vertical step size. Hence, the forming force and the thinning of the sheet material are considered responses to the output model. The results are given for both modes of layer positioning, depending on the material layer in contact with the tool. Moreover, this investigation aims to identify the influence of the process parameters on the grey relational grade (GRG) response through the analysis of variance (ANOVA). Additionally, the optimal conditions for both layer stacking approaches, contributing to achieving the minimum values of both responses and corresponding to the highest grey relational grade, are determined using the proposed optimization methodology to improve bimetal sheet formability. Finally, it could be observed that the optimization results proved the appropriateness and reliability of the developed techniques.
Evaluation of core Biomarkers of Alzheimer’s disease in saliva and plasma measured by chemiluminescent enzyme immunoassays on a fully automated platform
Authors: Agnello Luisa , Giglio Rosaria Vincenza , Ben Fabio Del , Piccoli Tommaso , Colletti Tiziana , Scazzone Concetta , Sasso Bruna Lo , Ciaccio Anna Maria , Gambino Caterina Maria , Salemi Giuseppe , Ciaccio Marcello 
Published: April 2024

Abstract
Background. Cerebrospinal fluid (CSF) core biomarkers of Alzheimer’s disease (AD), including amyloid peptide beta-42 (Aβ42), Aβ42/40 ratio, and phosphorylated tau (pTau), are precious tools for diagnosing AD. However, their use in clinical practice is limited due to the invasiveness of CSF collection. Thus, there is intensive research to find alternative, noninvasive, and widely accessible biological matrices to measure AD core biomarkers. In this study, we measured AD core biomarkers in saliva and plasma by a fully automated platform. Methods. We enrolled all consecutive patients with cognitive decline. For each patient, we measured Aβ42, Aβ40, and pTau levels in CSF, saliva, and plasma by Lumipulse G1200 (Fujirebio). Results. We included forty-two patients, of whom 27 had AD. Levels of all biomarkers significantly differed in the three biofluids, with saliva having the lowest and CSF the highest levels of Aβ42, Aβ40, and pTau. A positive correlation of pTau and Aβ42/40 ratio levels in CSF and plasma was detected, while no correlation between any biomarker in CSF and saliva was found. Conclusions. Our findings suggest that plasma but not saliva could represent a surrogate biofluid for measuring core AD biomarkers. Specifically, plasma Aβ42/40 ratio and pTau could serve as surrogates of the corresponding CSF biomarkers.