bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical effectiveness of Finger gliding Exercise for patients with trigger fingers receiving steroid injection: a Randomized Clinical Trial
Authors: Choi Yue Kwan , Sit Regina Wing-Shan , Wang Bo , Cheuk Christina , Lee Man Kei , Leung Kwan Wa Maria 
Published: February 2025

Abstract
Finger gliding exercises are believed to enhance flexor tendons excursion. This study assesses the effectiveness of finger gliding exercises in patients after receiving steroid injections for trigger fingers. Patients with trigger fingers who received corticosteroid injection were randomly assigned (1:1) to control and intervention group. The intervention group was required to do finger exercises and submit online exercise log regularly. The clinical outcomes of trigger fingers at 24 weeks and compliance with finger gliding exercises were assessed via online surveys. A total of 38 participants were allocated to each group. Baseline characteristics were similar, except for a longer duration of symptoms in the intervention group (5.2 ± 2.9 vs. 3.6 ± 2.6 months, P = 0.002). At 24 weeks, 34 (89.5%) control and 33 (86.8%) intervention group participants responded to online survey. No statistical significant differences were observed in Numerical Pain Rating Score, Quinelle grading, finger improvement rate, recurrence of triggering, need for repeated injection and occurrence of new trigger finger sites. The exercise log response rate and compliance rate were 85.6% and 68.6%. In conclusion, our study did not establish the clinical effectiveness of finger gliding exercise for trigger finger patients following steroid injections compared to usual care.
Long QT syndrome type 3 gain-of-function of Nav1.5 increases ventricular fibroblasts proliferation and pro-fibrotic factors
Authors: Castro Claire , Patin Justine , Jajkiewicz Cyrielle , Chizelle Franck , Cerpa Cynthia Ore , Tessier Agnès , Le Pogam Eva , Fellah Imen , Baró Isabelle , Charpentier Flavien , Derangeon Mickaël 
Published: February 2025

Abstract
The long QT syndrome type 3 (LQT3) is a cardiac channelopathy caused by gain-of-function mutations in the SCN5A gene, encoding the sodium channel Nav1.5. As Nav1.5 is expressed in cardiomyocytes but also in cardiac fibroblasts, we investigated whether the LQT3-causing p.ΔQKP1507-1509 (ΔQKP) SCN5A mutation alters cardiac fibroblast phenotype. Primary cultured ventricular fibroblasts from Scn5a
+/ΔQKP knock-in mice showed increased proliferation, survival, expression of transforming growth factor-β (TGF-β) and activation of its canonical pathway, and reduced α-smooth muscle actin expression. Ventricular tissue from Scn5a
+/ΔQKP mice exhibited augmented fibroblast populations and fibrosis. Inhibiting TGF-β receptor, sodium current or Scn5a expression decreased Scn5a
+/ΔQKP fibroblast proliferation, while veratridine increased proliferation of control fibroblasts, mimicking Nav1.5 gain-of-function. Lastly, abnormal calcium signaling underlied the increased proliferation of Scn5a
+/ΔQKP fibroblasts. Our study shows that cardiac fibroblasts carrying the ΔQKP-SCN5A mutation exhibit an abnormal, proliferative phenotype, paving the way for better understanding the role of cardiac fibroblasts in LQT3.
Cytochrome b5 occurrence in giant and other viruses belonging to the phylum Nucleocytoviricota
Authors: Lamb David C. , Goldstone Jared V. , Belhaouari Djamal Brahim , Andréani Julien , Farooqi Ayesha , Allen Michael J. , Kelly Steven L. , La Scola Bernard , Stegeman John J. 
Published: February 2025

Abstract
Cytochrome b5 is an electron transport protein found in eukaryotes and bacteria, and plays roles in energy production, lipid biosynthesis and cytochrome P450 biochemistry. Here we report that genes for cytochrome b5 occur broadly among viruses in the class Megaviricetes isolated from the deep ocean, freshwater and terrestrial sources, and human patients. Transcriptional analysis showed that Mimivirus bradfordmassiliense cytochrome b5 is expressed in the host and has characteristic spectral properties. Viral cytochrome b5s have either a unique N-terminal transmembrane anchor or are predicted to be soluble proteins. Virus cytochrome b5 proteins share 45–95% sequence identity with one another but no more than 25% identity with that in Acanthamoeba castellanii, a host for many giant viruses. Thus, the origin of cytochrome b5 genes in giant viruses remains unknown. Our findings raise questions regarding the evolution and diversity of cytochrome b5, and about the origin of viral haemoproteins in general.
Automatic multimode identification of complex industrial processes based on network community detection with manifold similarity
Authors: Sun Yan‐Ning , Qiao Hai‐Bo , Xu Hong‐Wei , Qin Wei , Gao Zeng‐Gui , Liu Li‐Lan 
Published: February 2025

AbstractComplex industrial processes usually exhibit multimode characteristics, meaning that statistical features of process data, such as mean, variance, and correlation, vary across different modes. Extracting critical information from these distinct modes can significantly enhance the accuracy and robustness of data‐driven models in process monitoring, condition evaluation, and quality improvement. Consequently, the multimode identification of industrial data becomes a paramount concern in data‐driven modelling. However, existing methods for multimode identification require prior knowledge to predetermine the number of modes and struggle to describe the similarity between high‐dimensional samples effectively. To address this issue, this study introduces an automatic multimode identification method based on complex network community detection. In this approach, each data sample is considered as a node, and manifold similarity is calculated to construct the complex network model. The method leverages weighted geodesic distances to capture the data's manifold structure and potential density, enabling better distinction between high‐dimensional samples in different modes. The greedy search algorithm with modularity maximisation is employed to partition nodes into modes without manual selection of the number of modes. Furthermore, a node degree‐based indicator is developed for online mode monitoring. Experimental studies on two examples demonstrate the effectiveness of the proposed method in uncovering multimode characteristics of complex industrial processes, highlighting its promising application potential.
Magnetic field and rotor impedance analysis of solid rotor induction motors using the multilayer analytical method
Authors: Xu Hao , Zhao Jinghong , Yan Sinian , Wang Hanming 
Published: February 2025

AbstractThis paper proposes a multilayer analytical model for calculating the magnetic field and equivalent circuit parameters of solid rotor induction motors (SRIM), and the B–H curve of rotor material is used to consider the influence of saturation effect of solid rotor. The equivalent circuit of SRIM based on surface impedance theory can fully consider the influence of rotor material. Then, the magnetic vector potential in the rotor is solved in the three‐dimensional electromagnetic field, and the rotor is segmented along the axial direction to obtain the end coefficient considering the axial non‐linear effect of the rotor. The air gap magnetic field distribution, rotor loss, rotor impedance and torque were analysed by finite element simulation, and the accuracy of the multilayer analytical model and end coefficient was verified. Compared with the finite element method, the analytical method proposed in this paper is time saving, resulting in that it is suitable for the optimised design. Finally, an experimental prototype is developed and tested, confirming the accuracy of both the finite element simulation and the analytical model.
Rapid system prototype‐based physical simulation platforms for power systems with high penetration of inverter‐based resources
Authors: Yao Wei , Ruan Yimin , Chen Yuying , Zhou Hongyu , Wen Jinyu , Zhou Meng , Zuo Wenping 
Published: February 2025

AbstractThe traditional power system dominated by synchronous generators is gradually evolving into a power system with high penetration of inverter‐based resources (IBRs). In this paper, the new characteristics that arise from the high penetration of IBRs in power systems are reviewed. In light of these characteristics, current simulation technologies are inadequate and new requirements for the simulation platforms have been proposed. In response, this paper introduces the rapid system prototype (RSP)‐based physical simulation platforms, which include the digital simulator, the rapid prototype controller, and the rapid object‐controlled prototype. RSP addresses the time‐consuming and labour‐intensive shortcomings of traditional simulation techniques and meets the rapid evolution needs of the power system with high penetration of IBRs. Compared with existing simulation platforms, RSP is a more suitable platform for the physical simulation of power systems with high penetration of IBRs. Using the modular multilevel converter‐based high‐voltage direct current as a case study, a novel physical simulation platform for power systems based on RSP is constructed. Experimental results demonstrate that the RSP concept and technology can establish an enterprise‐level simulation environment and engineering practice platform. Moreover, it can provide realistic and flexible simulations of various characteristics of power systems with high penetration of IBRs.
Experimental demonstrations of high‐accuracy 3D/2D indoor visible light positioning using imaging multiple‐input multiple‐output receivers and artificial neural networks
Authors: Apolo Juan. A. , Osahon Isaac. N. O. , Ortega Beatriz , Almenar Vicenç , Tang Jianming , Rajbhandari Sujan 
Published: February 2025

AbstractThis paper proposes and presents the first experimental demonstration of a high‐precision indoor 2D and 3D visible light positioning (VLP) system using an imaging multiple‐input multiple‐output (MIMO) configuration with supervised artificial neural network. The proposed system utilises four distributed transmitters and receiver with four photodiodes and an imaging optics. The experiments are conducted in a typical indoor environment with transmitter separations of 300 mm and a link distance of 1400 mm. The experimental results show 2D and 3D positioning accuracies of 3.7 and 51 mm, respectively. A simulation model is also developed for the VLP system to validate the experimental results. Further optimisation of the VLP system in the simulation platform leads to improved 2D and 3D positioning accuracies of 2 and 14.7 mm, respectively. The proposed system can be seamlessly integrated with existing lighting infrastructures and is also compatible with the MIMO visible light communication system, indicating the potential for practical implementation in integrated communications and positioning applications.
« Un modèle unique dans un parc standardisé »
Authors: Dutheil Étienne 
Published: February 2025

À l’automne dernier, Étienne Dutheil, directeur de la Division production nucléaire chez EDF, est revenu pour la Sfen sur la singularité de l’EPR de Flamanville 3, mis en service le 2 septembre 2024 et raccordé au réseau le 21 décembre 2024 : parvenir à s’intégrer comme nouveau réacteur destiné à demeurer unique dans un vaste parc nucléaire français standardisé.
Metodologia LipoCodes: Controle objetivo de volumes infiltrados e aspirados em lipoaspiração
Authors: Gomes Rogerio Schützler 
Published: February 2025

Resumo
Introdução As técnicas atuais, tecnologias e publicações de lipoaspiração continuam a evoluir, buscando resultados melhores e mais previsíveis com o máximo de segurança possível. Por outro lado, não há referências a controles de volume mais objetivos para obter resultados mais precisos e previsíveis na lipoaspiração, parâmetros objetivos que poderiam melhorar os resultados e a segurança. Dentro deste contexto, foi desenvolvida uma metodologia para obter informações objetivas de segurança, apoiar a reposição de fluidos e o controle de volumes aspirados por região e total, otimizando dessa forma o tempo cirúrgico. O objetivo deste trabalho é descrever uma metodologia denominada Lipocodes, criada para aferir o volume infiltrado e aspirado, o tempo e a velocidade cirúrgica, em procedimentos de lipoaspiração e/ou lipoenxertia.
Materiais e Métodos A metodologia LipoCodes é baseada em regiões de depósito de gordura e regiões de enxerto; níveis de profundidade da lipoaspiração; portais de acesso (incisões); controle de volumes infiltrados e aspirados.
Resultados A metodologia LipoCodes desenvolveu o controle de volumes infiltrados, de sucção de gordura, e de enxerto de gordura, para cada região previamente definida, bem como a velocidade de lipoaspiração.
Discussão A metodologia LipoCodes foi desenvolvida para sistematizar a lipoaspiração, independentemente do equipamento e da técnica preferida de cada cirurgião plástico. O objetivo é tornar a lipoaspiração mais controlada, objetiva, didática e educacional, com mais previsibilidade.
Conclusão A metodologia LipoCodes utiliza equipamentos simples para medir cada mililitro de volume infiltrado, aspirado e enxertado de regiões corporais previamente definidas. Essas informações auxiliam com parâmetros objetivos, controle de volumes em lipoaspiração, bem como controle do tempo cirúrgico.
Miniaturized near-field polarization photodetector
Authors: Zheng Yingshuang , Zhu Fei , Jin Chunqi , Fan Yandong , Sun Xiaojuan , Li Dabing , Li Wei 
Published: February 2025

Abstract
As an inherent and important property of light, polarization could provide information beyond light intensity and spectrum. However, traditional polarization detectors require bulky polarization optics and accurate heterogeneous integration, which limits their miniaturization. Conversely, recently developed miniaturized near-field polarization photodetectors can efficiently achieve detection with the advantages of being filterless, cost-effective, and portable. These attributes play a significant role in various fields, including astronomy, quantum optics, and medical diagnosis. In this paper, we review the progress of miniaturized near-field polarization photodetectors, including polarization photodetectors based on the nanowire, two-dimensional materials, chiral materials, and metasurface. Furthermore, this review analyzes the detection mechanisms of these photodetectors and provides a comprehensive summary of their operational wavelengths, photo responsivities, and polarization sensitivities, including polarization ratio for linear polarization and asymmetric ratio for circular polarization. Finally, the applications of near-field polarization photodetector are reviewed to highlight its potential in broad aspects of applications.
Refractive index modification and plasma characteristics of a femtosecond laser-induced filament in nitrogen
Authors: Pokharel Sagar , Miles Richard , Tropina Albina 
Published: February 2025

Abstract
The paper presents a detailed analysis of the change in the refractive index field during the decay of laser plasma in nitrogen at atmospheric pressure. The mathematical model combines a three-temperature nonequilibrium plasma model with detailed kinetics and a semi-classical refractive index model based on species polarizabilities. A detailed characterization of the femtosecond plasma for a wide range of initial electron density and electron temperature forms the basis of the refractive index analysis. The study provides a quantitative evaluation of the effects of vibrational nonequilibrium, dissociation, ionization, and hydrodynamics on the refractive index field. The fast temporal evolution of the refractive index at early times during the laser plasma decay is explained by the exponential decay of the electron density, with dissociation and vibrational excitation of molecular nitrogen being equally important factors. The study of relative contributions to the evolution of the refractive index field has significance for diagnostics, laser energy deposition, and wave-guiding.
Construction and test of the 19.6-T solid-nitrogen-cooled REBCO insert magnet for the MIT 1.3-GHz NMR system
Authors: Dong Fangliang , Park Dongkeun , Sadde Patricia , Bascuñán Juan , Iwasa Yukikazu 
Published: February 2025

Abstract
This work presents the construction, testing, and analyses work of the 835 MHz high-temperature superconducting REBCO insert magnet (H835), a critical component of the ongoing MIT 1.3 GHz HTS/LTS NMR Magnet project (1.3 G). H835 consists of 40 double-pancake coils operating in a solid nitrogen environment at temperatures ranging from 4 to 17 K. It is designed to generate a central magnetic field of 19.6 T within a 79.4 mm clear bore that will house a 54 mm standard warm bore in the future 1.3 GHz NMR system. Building on lessons learned from our previous 18.8 T REBCO insert magnet (H800), which experienced quenching in 2018 that resulted in permanent damage, several improvements have been implemented in this new H835 design and construction. We have charged H835 to the rated current of 230 A and maintained its central field of 19.43 T for over 15 h without any issues before ramping down the current. The 0.17 T (0.87%) error field between measurement and design was due to screening current effect. H835 will be combined with the low-temperature superconducting 500 MHz background magnet (L500) to complete 1.3 G. We believe that this solid-nitrogen-cooled H835 can provide valuable insights for developing high-field liquid-helium-free REBCO magnets.
Study on the influence of geometric shape of plate welded joint on crack propagation of weld toe
Authors: Li Guangze , Shen Yuxin , Xue Caijun 
Published: February 2025

Abstract
Crack propagation at the welded joints is an important mode of failure in welded structures. The influences of welded joints’ geometric parameters on toe crack propagation were studied during this research work. Through the finite element software ANSYS 2020, the stress intensity factor values of the crack at the welded joint toe and the non-welded plate crack under uniform drawing load were calculated by the interaction integral method. The ratio of stress intensity factor at the crack tip of the joint toe to stress intensity factor of the non-welded plate crack was set as a geometric influence factor. Through the geometric influence factor, the influences of geometric parameters on the stress intensity factor were analyzed. The results show that the crack tip stress intensity factor at the toe is mainly affected by the thickness of the plate, the radius of the toe, the angle of the toe, the widths of the upside and downside welds, the heights of the upside and downside reinforcements and the crack length. The stress intensity factor decreases with the increase of toe radius, but increases with the increase of the other parameters under the condition of constant crack length. The geometric influence factor decreases with the increase of crack length, and the decrease range is between 34% and 47%. The geometric influence factor expression of the stress intensity factor at the toe crack tip of the welded joint under uniform drawing external load was obtained by regression analysis of the finite element calculation results. The error is less than 5% within the selected value ranges, which indicates that the expression is suitable for toe cracks of plate welded joints of most common sizes.
Application progress of bio-manufacturing technology in kidney organoids
Authors: Mao Runqi , Zhang Junming , Qin Haoxiang , Liu Yuanyuan , Xing Yuxin , Zeng Wen 
Published: February 2025

Abstract
Kidney transplantation remains a pivotal treatment modality for kidney disease, yet its progress is significantly hindered by the scarcity of donor kidneys and ethical dilemmas surrounding their procurement. As organoid technology evolves and matures, the creation of bionic human kidney organoids offers profound potential for advancing kidney disease research, drug nephrotoxicity screening, and regenerative medicine. Nevertheless, current kidney organoid models grapple with limitations such as constrained cellular differentiation, underdeveloped functional structures, and a crucial absence of vascularization. This deficiency in vascularization, in particular, stunts organoid development, restricts their size, diminishes filtration capabilities, and may trigger immune inflammatory reactions through the resulting ischemic microenvironment. Hence, the achievement of vascularization within kidney organoids and the successful establishment of functional microvascular networks constitutes a paramount goal for their future progression. In this review, we provide an overview of recent advancements in biotechnology domains, encompassing organ-on-a-chip technology, biomimetic matrices, and bioprinting, with the aim of catalyzing technological breakthroughs that can enhance the vascularization of kidney organoids and broaden their applicability. These technologies hold the key to unlocking the full potential of kidney organoids as a transformative therapeutic option for kidney disease.
Real-time assessment of cell concentration and viability onboard a syringe using dielectric impedance spectroscopy for extrusion bioprinting
Authors: Matavosian Alicia A , Griffin Alexandra C , Bhuiyan Didarul B , Lyness Alexander M , Bhatnagar Vivek , Bonassar Lawrence J 
Published: February 2025

Abstract
Bioprinting produces personalized, cell-laden constructs for tissue regeneration through the additive layering of bio-ink, an injectable hydrogel infused with cells. Currently, bioprinted constructs are assessed for quality by measuring cellular properties post-production using destructive techniques, necessitating the creation of multiple constructs and increasing the production costs of bioprinting. To reduce this burden, cell properties in bio-ink can be monitored in real-time during printing. We incorporated dielectric impedance spectroscopy (DIS) onto a syringe for real-time measurement of primary chondrocytes suspended in phosphate buffered saline (PBS) using impedance (|Z|) and phase angle (θ) from 0.1 to 25 000 kHz. Cell concentration and viability ranged from 0.1 × 106 cells ml−1 to 125 × 106 cells ml−1 and from 0%to 94%, respectively. Samples with constant or with changing cell concentration were exposed to various flow conditions from 0.5 to 4 ml min−1. The background PBS signal was subtracted from the sample, allowing for comparisons across devices and providing insight into the dielectric properties of the cells, and was labeled as |Zcells
| and θcells
. |Zcells
| shared a linear correlation with cell concentration and viability. Flow rate had minimal effect on our results, and |Zcells
| responded on the order of seconds as cell concentration was altered over time. Notably, sensitivity to cell concentration and viability were dependent on frequency and were highest for |Zcells
| when θcells
was minimized. Cell concentration and viability showed an additive effect on |Zcells
| that was modeled across multiple frequencies, and deconvolution of these signals could result in real-time predictions of cell properties in the future. Overall, DIS was found to be a suitable technique for real-time sensing of cell concentration and viability during bioprinting.