bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Radical Cations in Electrospray Mass Spectrometry: Formation of Open‐Shell Species, Examination of the Fragmentation Behavior in ESI‐MSn and Reaction Mechanism Studies by Detection of Transient Radical Cations
Authors: Schaefer Mathias , Drayss Miriam , Springer Andreas , Zacharias Philipp , Meerholz Klaus 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Self‐Association and Crystallization of Amylose
Authors: Buleon Alain , Veronese Gabrielle , Putaux Jean‐Luc 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Supramolecular Biomaterials. A Modular Approach Towards Tissue Engineering
Authors: Dankers Patricia Y. W. , Meijer E. W. 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Plant Oil Renewable Resources as Green Alternatives in Polymer Science
Authors: Meier Michael A. R. , Metzger Juergen O. , Schubert Ulrich S. 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: High‐Velocity DC‐VPS for Diffusion and Protecting Barrier Layers in Solid Oxide Fuel Cells (SOFCs)
Authors: Henne R. H. , Franco T. , Ruckdaeschel R. 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Electrospinning of Nanofibers: Towards New Techniques, Functions, and Applications
Authors: Dersch Roland , Graeser Martin , Greiner Andreas , Wendorff Joachim H. 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Tailoring Tripodal Ligands for Zinc Sensing
Authors: Dai Zhaohua , Canary James W. 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Interparticle Coupling Effect on the Surface Plasmon Resonance of Gold Nanoparticles: From Theory to Applications
Authors: Ghosh Sujit Kumar , Pal Tarasankar 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Derivative Spectrophotometric and NMR Spectroscopic Study in Pharmaceutical Science
Authors: Kitamura Keisuke 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Synthesis of Multi‐Substituted 2‐Iminopyridine by Conjugate Addition of Ethyl Cyanoacetate Derivatives to Alkynyl Imines
Authors: Hachiya Iwao , Minami Yushi , Aramaki Tetsuya , Shimizu Makoto 
Published: January 2008

AbstractThe synthesis of multi‐substituted 2‐iminopyridines by conjugate addition of ethyl cyanoacetate derivatives to alkynyl imines has been developed. The reaction of ethyl cyanoacetate derivatives with alkynyl imines provided multi‐substituted 2‐iminopyridines in good yields. Also described is the transformation of 2‐iminopyridines into 2‐aminopyridines by deprotection of the substituent on the nitrogen under acidic conditions. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Activation of dorsal horn microglia contributes to diabetes‐induced tactile allodynia via extracellular signal‐regulated protein kinase signaling
Authors: Tsuda Makoto , Ueno Hikaru , Kataoka Ayako , Tozaki‐Saitoh Hidetoshi , Inoue Kazuhide 
Published: January 2008

AbstractPainful neuropathy is one of the most common complications of diabetes, one hallmark of which is tactile allodynia (pain hypersensitivity to innocuous stimulation). The underlying mechanisms of tactile allodynia are, however, poorly understood. Emerging evidence indicates that, following nerve injury, activated microglia in the spinal cord play a crucial role in tactile allodynia. However, it remains unknown whether spinal microglia are activated under diabetic conditions and whether they contribute to diabetes‐induced tactile allodynia. In the present study, using streptozotocin (STZ)‐induced diabetic rats that displayed tactile allodynia, we found several morphological changes of activated microglia in the dorsal horn. These included increases in Iba1 and OX‐42 labeling (markers of microglia), hypertrophic morphology, the thickness and the retraction of processes, and in the number of activated microglia cells. Furthermore, in the dorsal horn of STZ diabetic rats, extracellular signal‐regulated protein kinase (ERK) and an upstream kinase, Src‐family kinase (SFK), both of which are implicated in microglial functions, were activated exclusively in microglia. Moreover, inhibition of ERK phosphorylation in the dorsal horn by intrathecal administration of U0126, an inhibitor of ERK activation, produced a striking alleviation of existing, long‐term tactile allodynia of diabetic rats. We also found that a single administration of U0126 reduced the expression of allodynia. Together, these results suggest that activated dorsal horn microglia may be a crucial component of diabetes‐induced tactile allodynia, mediated, in part, by the ERK signaling pathway. Thus, inhibiting microglia activation in the dorsal horn may represent a therapeutic strategy for treating diabetic tactile allodynia. © 2008 Wiley‐Liss, Inc.
Renal effects of long‐term lithium therapy in the elderly: a cross‐sectional study
Authors: van Melick Els J. M. , Meinders Arend E. , Hoffman Tonko O. , Egberts Toine C. G. 
Published: January 2008

AbstractObjectivesTo determine the effect of long‐term lithium therapy on glomerular filtration rate (GFR) and maximum renal concentrating capacity (Umax) in the elderly, to identify possible risk factors, to determine the clinical impact of a reduced Umax in this population and in case of polyuria to establish a diagnosis.MethodsThis is a cross‐sectional study with 48 outpatients of 65 years or over (mean 74.8 years), who were treated with lithium for more than 6 months (mean 9.2 years). The GFR was determined with the Cockcroft‐Gault formula (GFR‐CG) and the Umax was measured in a urine sample collected between 3 and 5 h after the patients received 40 μg desmopressin (DDAVP) intranasally.ResultsNo relation was found between duration of lithium treatment and GFR‐CG, but there was a significant negative relation between duration of lithium treatment and Umax (B −0.73; CI: −1.249/−0.212); 73% of the patients had a moderate to severe concentrating defect. No other risk factors than duration of lithium therapy were identified. A reduced Umax caused polyuria (>2500 mL/24 h) in 33% but did not cause significant more thirst, incontinence or disturbed sleep.ConclusionsIn this geriatric population a negative relation was found between duration of lithium treatment and Umax. But a reduced Umax did not result in significant more clinical symptoms. In case of polyuria other mechanisms beside nephrogenic diabetes insipidus were found to play a role in this age group. Copyright © 2008 John Wiley & Sons, Ltd.
Modification and testing of a one‐dimensional energy and mass balance model for supraglacial snowpacks
Authors: Fox Andrew M. , Willis Ian C. , Arnold Neil S. 
Published: January 2008

AbstractA one‐dimensional energy and mass balance snow model (SNTHERM) has been modified for use with supraglacial snowpacks and applied to a point on Haut Glacier d'Arolla, Switzerland. It has been adapted to incorporate the underlying glacier ice and a site‐specific, empirically derived albedo routine. Model performance was tested against continuous measurements of snow depth and meltwater outflow from the base of the snowpack, and intermittent measurements of surface albedo and snowpack density profiles collected during the 1993 and 2000 melt seasons. Snow and ice ablation was simulated accurately. The timing of the daily pattern of meltwater outflow was well reproduced, although magnitudes were generally underestimated, possibly indicating preferential flow into the snowpack lysimeter. The model was used to assess the quantity of meltwater stored temporally within the unsaturated snowpack and meltwater percolation rates, which were found to be in agreement with dye tracer experiments undertaken on this glacier. As with other energy balance studies on alpine valley glaciers, the energy available for melt was dominated by net radiation (64%), with a sizable contribution from sensible heat flux (36%) and with a negligible latent heat flux overall, although there was more complex temporal variation on diurnal timescales. A basic sensitivity analysis indicated that melt rates were most sensitive to radiation, air temperature and snowpack density, indicating the need to accurately extrapolate/interpolate these variables when developing a spatially distributed framework for this model. Copyright © 2008 John Wiley & Sons, Ltd.
Design and field tuning of an upstream controlled canal network SCADA
Authors: Rijo M. 
Published: January 2008

AbstractThis paper presents the design, implementation and field tuning of a SCADA of an irrigation canal network upstream controlled with AMIL gates and equipped with other Neyrpic devices. Besides the hydraulic system, the paper also presents the supervisory and control system and its remote terminal units. The developed and field‐tuned manual and automatic controllers are also presented. The manual controllers – direct and gate position controllers and gate flow controllers – are defined for the main canal intakes in order to permit achievement of predefined flow values or daily flow schedules, and are also defined for a few gate‐controlled canal orifices used to discharge the overflow to the drainage system. The automatic controllers – water depth controllers for a few gate‐controlled canal orifices – are defined in order to automatically prevent canal overtopping.The SCADA system also monitors the outflows at the main canals – the most important canal top side weirs, canal terminal weirs and automatic Neyrpic siphons. The flow equations used in the computing of flow in real time inside the developed controllers and the monitoring units were field tuned using collected data readings from a monostatic Doppler current meter. The tuning parameters are also defined and presented. Copyright © 2008 John Wiley & Sons, Ltd.
Helical domain collagen substrates mineralization in simulated body fluid
Authors: Falini Giuseppe , Fermani Simona , Palazzo Barbara , Roveri Norberto 
Published: January 2008

AbstractHelical domain collagen substrates had been mineralized using simulated body fluid. They had an increasing level of structural organization; being in the form of gel, film, and uniaxial deformed film. The experiments were carried out for different periods of time and the obtained composite materials were characterized in their mineral content. Apatite precipitation was detected. The results show that the helical domain collagen substrates partially inhibit the in vitro apatite precipitation processes, but the amount and the crystallinity of deposited mineral can be controlled by the different assemblies of the helical domain collagen fibers. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2008
Biocompatibility of a functionally graded bioceramic coating made by wide‐band laser cladding
Authors: Weidong Zhu , Qibin Liu , Min Zheng , Xudong Wang 
Published: January 2008

AbstractThe application of plasma spray is the most popular method by which a metal‐bioceramic surface composite can be prepared for the repair of biological hard‐tissue, but this method has disadvantages. These disadvantages include poor coating‐to‐substrate adhesion, low mechanical strength, and brittleness of the coating. In the investigation described in this article, a gradient bioceramic coating was prepared on a Ti‐6Al‐4V titanium alloy surface using a gradient composite design and wide‐band laser cladding techniques. Using a trilayer‐structure composed of a substratum, an alloy and bioceramics, the coating was chemically and metallurgically bonded with the substratum. The coating, which contains β‐tricalcium phosphate and hydroxyapatite, showed favorable biocompatibility with the bone tissue and promoted in vivo osteogenesis. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2008
Guided growth of smooth muscle cell on poly(3‐hydroxybutyrate‐co‐3‐hydroxyhexanoate) scaffolds with uniaxial microtubular structures
Authors: Chen Song , Wang Pei‐Pei , Wang Jin‐Peng , Chen Guo‐Qiang , Wu Qiong 
Published: January 2008

AbstractScaffolds of biopolyester poly(3‐hydroxybutyrate‐co‐3‐hydroxyhexanoate) (PHBHHx) with uniaxial microtubular structure were successfully prepared by directional freezing and phase‐separation techniques. These special structures guided the rabbit aorta smooth muscle cells (RaSMCs) to grow along the tubular structure. The structure of the scaffolds including tubular size and architecture, as well as scaffold mechanical properties could be adjusted by changing the PHBHHx concentration, PHBHHx solvent, and phase‐separation temperature. In addition, the scaffolds demonstrated anisotropic mechanical properties, with much more improved strength along the longitudinal direction of the microtubules compared with those along the transverse direction. Three‐day and 7‐day cell culture of RaSMCs seeded on the scaffolds with different microtubular sizes showed similar cellular metabolic activity but different cell distribution and morphology owing possibly to different scaffold tubular sizes. The scanning electron microscopy and H&E staining demonstrated that RaSMCs were guided to grow along the microtubular structures of scaffolds prepared from the 2.5% or 3.0% PHBHHx/benzene solution. This study demonstrated the possibility of using PHBHHx scaffolds to achieve guided cell growth. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2008
A preliminary study on MeO‐PEG‐PLGA‐PEG‐OMe nanoparticles as intravenous carriers
Authors: Duan Yourong , Xu Jinping , Lin Yunzhu , Yu Hui , Gong Tao , Li Yaogang , Zhang Zhirong 
Published: January 2008

AbstractTo develop an intravenous nanoparticle delivery system for a cancer drug (i.e., DHAQ, mitoxantrone), the synthesis of a biodegradable polyester polymer with hydrophilic polyethylene glycol chains, preparation of DHAQ‐loaded nanoparticles from such polymer and biodistribution of the drug‐loaded particles were investigated in this article. Biodegradable monomethoxy poly(ethylene glycol)‐poly (lactide‐co‐glycolide)‐monomethoxy poly(ethylene glycol) (MeO‐PEG‐PLGA‐PEG‐OMe, PELGE) copolymers were synthesized by ring‐opening polymerization as the drug carriers. A double emulsion method with dextran‐70 as an emulsifier was employed to prepare the nanoparticles. DHAQ‐PELGE nanoparticles and free DHAQ were employed for the in vivo biodistribution studies after intravenous administration through the tail veins in mice. At various time intervals, the mice were sacrificed and several organs and tissues harvested, including hearts, livers, spleens, lungs, kidneys, and blood. The DHAQ concentrations in the collected tissues and plasmas were determined using high performance liquid chromatography. The DHAQ concentrations in mice plasmas in the experimental groups were significantly higher than those in the control group and 3.72% of total administrations dosages (TAD) of these particles with DHAQ remained in circulation even 96 h after intravenous injection. Compared with the free DHAQ, DHAQ‐loaded PELGE nanoparticles had longer circulation properties. Further research should be done for intravenous injection of this material as drug carriers. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2008
Primary sequence of ionic self‐assembling peptide gels affects endothelial cell adhesion and capillary morphogenesis
Authors: Sieminski A. L. , Semino C. E. , Gong H. , Kamm R. D. 
Published: January 2008

AbstractAppropriate choice of biomaterial supports is critical for the study of capillary morphogenesis in vitro as well as to support vascularization of engineered tissues invivo. Self‐assembling peptides are a class of synthetic, ionic, oligopeptides that spontaneously assemble into gels with an ECM‐like microarchitecture when exposed to salt. In this paper, the ability of four different self‐assembling peptide gels to promote endothelial cell adhesion and capillary morphogenesis is explored. Human umbilical vein endothelial cells (HUVECs) were cultured within ionic self‐assembling peptide family members, RAD16‐I ((RADA)4), RAD16‐II ((RARADADA)2), KFE‐8 ((FKFE)2), or KLD‐12 ((KLDL)3). HUVECs suspended in RAD16‐I or RAD16‐II gels elongated and formed interconnected capillary‐like networks resembling in vivo capillaries, while they remained round and formed clusters within KFE‐8 or KLD‐12 gels. As HUVECs attach to RAD16‐I and RAD16‐II significantly better than the other peptides, these differences appear to be explained by differences in cell adhesion. Although adhesion likely occurs via bound adhesion proteins, there appears to be no difference in protein binding to the peptides investigated. Results indicate that, although these oligopeptides have similar mechanisms of self‐ assembly, their primary sequence can greatly affect cell adhesion. Additionally, a subset of these biomimetic ECM‐like materials support capillary morphogenesis and thus may be useful for supporting vascularization. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2008
Evaluation of cell affinity on poly(L‐lactide) and poly(ε‐caprolactone) blends and on PLLA‐b‐PCL diblock copolymer surfaces
Authors: Ajami‐Henriquez Diana , Rodríguez Mónica , Sabino Marcos , Castillo R. Verónica , Müller Alejandro J. , Boschetti‐de‐Fierro Adriana , Abetz Clarissa , Abetz Volker , Dubois Philippe 
Published: January 2008

AbstractAn evaluation of cell proliferation and adhesion on biocompatible film supports was performed. A series of films were compression molded from commercially available poly (L‐lactide), PLLA, and poly(ε‐caprolactone), PCL, and from their melt mixed blends (PLLA/PCL blends). These were compared with compression molded films of PLLA‐b‐PCL model diblock copolymers. The samples were analyzed by differential scanning calorimetry (DSC), contact angle measurements, and scanning force microscopy (SFM). Cell adhesion and proliferation were performed with monkey derived fibroblasts (VERO) and with osteoblastic cells obtained either enzymatically or from explants cultures of Sprague–Dawley rat calvaria. Migration studies were performed with bone explants of the same origin. The results obtained indicate that although all materials tested were suitable for the support of cellular growth, a PLLA‐b‐PCL diblock copolymer sample with 93% PLLA was significantly more efficient. This sample exhibited a unique surface morphology with long range ordered domains (of the order of 2–3 μm) of edge‐on PLLA lamellae that can promote “cell contact guidance.” The influence of other factors such as chemical composition, degree of crystallinity, and surface roughness did not play a major role in determining cell preference toward a specific surface for the materials employed in this work. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2008
Study on the biocompatibility of novel terpolyester poly(3‐hydroxybutyrate‐co‐3‐hydroxyvalerate‐co‐3‐hydroxyhexanoate)
Authors: Liang Yan‐Sheng , Zhao Wei , Chen Guo‐Qiang 
Published: January 2008

AbstractTerpolyester poly(3‐hydroxybutyrate‐co‐3‐hydroxyvalerate‐co‐3‐hydroxyhexanoate) (PHBVHHx) containing 5.3 mol % 3‐hydroxyvalerate (3‐HV) and 10.2 mol % 3‐hydroxyhexanoate was obtained via microbial synthesis using recombinant Aeromonas hydrophila. For the first time in vitro biocompatibility of the terpolyester was evaluated in comparison with poly(L‐lactic acid), poly (3‐hydroxybutyrate), poly(3‐hydroxybutyrate‐co‐3‐hydroxyvalerate), and poly(3‐hydroxybutyrate‐co‐3‐hydroxyhexanoate) (PHBHHx). Scanning electron microscopy showed whorls‐like morphology only on PHBVHHx film surface. Methylthiazol tetrazolium assay demonstrated that PHBVHHx was better than the above four materials in promoting cell attachment and proliferation of fibroblast cell line L929 and osteoblast cell line MC3T3, respectively. Histological study using rabbits proved that PHBVHHx was a fairly harmless implantable biomaterial. Thus, PHBVHHx with an adjustable mechanical properties, combined with its biocompatibility, are in the process of developing into a new generation of bioimplant material. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2008