bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of infections in hickman and implanted port catheters in adult solid tumor patients
Authors: Pegues David , Axelrod Peter , McClarren Carol , Eisenberg Burton L. , Hoffman John P. , Ottery Faith D. , Keidan Richard D. , Boraas Marcia , Weese James 
Published: February 2007

AbstractLong term therapy of oncology patients has been facilitated by permanent indwelling central venous catheters, but catheterrelated infections remain a serious complication of their use. Using a retrospective matched cohort design, we compared the risk of catheterrelated infection in 47 adult solid tumor patients with right atrial Hickman catheters and 94 patients with totally implanted port catheters. Patients were matched for primary solid tumor, presence of metastases, age, gender, and date of catheter insertion. Seven of 47 patients with Hickman catheters developed catheterrelated infection (1.8 infections/1,000 catheter days at risk) compared with 10 of 94 patients with implanted port catheters (0.4/1000 catheter daysp< 0.0002). Hickman catheters were used more often for terminally ill patients than were port catheters which was a potential source of bias, but results were unchanged after stratifying patients on lifespan. Our study suggests that there are fewer infections in port than in Hickman catheters in adult patients with solid tumors, but prospective randomized studies are needed.
Androgen effect on prostate specific antigen secretion
Authors: Hanash Kamal A. , Mostofi Kash F. 
Published: February 2007

AbstractProlonged parenteral androgen therapy for 1 year resulted in the hypersecretion of prostate specific antigen (PSA) in a patient with no clinical evidence of prostatic carcinoma, who had been treated with diethylstilbestrol (DES) for 9 years. The PSA level declined to normal values upon temporary discontinuation of androgen therapy and increased again upon resumption of treatment. This case seems to confirm the regulatory effect of androgens of PSA secretion and to suggest a possible “rebound” elevation of PSA in patients with androgen deprivation treated with testosterone replacement. The estrogen suppressed prostatic epithelial cells were able to respond to androgen stimulation with a steady increase in the PSA secretion and positive immunohistochemical PSA staining.
Carcinoma of the thyroid in black patients
Authors: Brooks Michael E. , Rogers Norman , Ransome Rodman , Leffall Lasalle D. 
Published: February 2007

AbstractIn the period from January 1,1976 to December 31, 1988, we reviewed the charts of 33 patients treated for carcinoma of the thyroid at Howard University Hospital. The three non‐black patients (two Whites and one Pakistani) were excluded from the study. There were 19 females and 11 males. Of the 30 cases elevated, 10 were papillary, 7 were follicular variant of papillary, 8 were follicular, 3 were undifferentiated (anaplastic), and 2 were medullary. Ten patients had either distant metastasis (Hoffman, South Med J 80:741, 1987) or locally advanced disease in the neck (Woolner et al., Am J Surg 102:354, 1961.) at the time of diagnosis. The treatment of these lesions depended on, among other variables, the cell type, the extent of the lesion, and the personal preference of the attending surgeon. Carcinoma of the thyroid remains an uncommon lesion in Black patients. Because of its rarity, the diagnosis may often be delayed and, as a result, patients may first come to attention with a more advanced stage of this disease. To prevent this occurrence, a high index of suspicion must be maintained for all thyroid nodules, and appropriate diagnostic steps taken. Diagnostic and treatment options are discussed. © 1992 WiIey‐Liss, Inc.
Outcome of patients with lung cancer detected via mass screening as compared to those presenting with symptoms
Authors: Shimizu Nobuyoshi , Ando Akio , Teramoto Shigeru , Moritani Yoshiaki , Nishii Kenji 
Published: February 2007

AbstractWe performed lung cancer resection in 721 patients between 1980 and 1989. Cancers were detected via mass screening programs by annual chest X‐ray examination in the majority of cases. We evaluated the surgical results in patients with tumors detected by mass screening and compared them to those in whom the malignancy was detected by symptoms. Lesions in the mass screened group were T1 to T2 tumors in 90% of the cases, and NO in 73%. Stage I disease accounted for 65.3% in the mass screened group. The overall 5‐year survival rate was 56.2% in the mass screened group, which was significantly better than the 25.3% for the symptom group (P < 0.001). The surgical results in the lung cancer cases detected by the mass screening program had better results than the cases who presented with symptoms. © 1992 Wiley‐Liss, Inc.
Bone metastases of hepatocellular carcinoma after liver resection
Authors: Taki Y. , Yamaoka Y. , Takayasu T. , Ino K. , Shimahara Y. , Mori K. , Morimoto T. , Ozawa K. 
Published: February 2007

AbstractBetween January 1985 and July 1990, 323 cases of hepatocellular carcinoma underwent liver resection in our department. Bone metastases were found in 12 of these cases (3.7%). Bone metastases were mainly found in vertebral bone (58.3%) and pelvic bone (41.7%). The time interval to the development of bone metastasis after liver resection was closely related to the presence of intrahepatic metastasis and the stage at operation. In all cases, the initial clinical symptom was pain and/or motor disturbance. Radiotherapy was performed in 10 cases and transcatheter arterial embolization or surgery was performed in 4 cases. The pain or neurological symptoms improved with these therapies in all cases. Cumulative survival was 1 year in 74%, 2 years in 34%, and 3 years in 17%, respectively. © 1992 Wiley‐Liss, Inc.
Effects of surgical treatment in thymoma with myasthenia gravis: Our experience in 103 patients
Authors: Crucitti Francesco , Doglietto Giovanni Battista , Bellantone Rocco , Perri Vincenzo , Tommasini Oscar , Tonali Pietro 
Published: February 2007

AbstractA retrospective study of 103 thymectomies examines the effects of the integration of surgical and medical therapy in patients affected by myasthenia gravis accompanied by thymoma. An extended thymectomy via a median longitudinal sternotomy was used in 102 patients. The operative mortality was 4.85% (5/103 patients), the 10‐year survival rate was 78% with a recurrence rate of 3.06% (3/98). Neoplastic infiltration and postoperative radiotherapy did not influence the survival rate. There was no correlation between a preoperative Osserman's class better than III and postoperative outcome. The improvement of medical treatment, and anaesthesiological and intensive care techniques resulted in a decrease of the operative mortality and long‐term death rate during the last 10 years of our 20‐year series. Extended thymectomy via sternotomy is the best intervention in patients with myasthenia gravis associated with thymoma judged by the low operative mortality and the favorable 10‐year survival rates. © 1992 Wiley‐Liss, Inc.
Arm function after axillary dissection for breast cancer: A pilot study to provide parameter estimates
Authors: Hladiuk Marianne , Huchcroft Shirley , Temple Walley , Schnurr B. Elisabeth 
Published: February 2007

AbstractSixty‐three women participated in a study in Calgary, Alberta to assess the rate of arm recovery and factors affecting it up to one year after axillary node dissection for breast cancer. Outcomes included objective measures of swelling, mobility, and strength, and subjective assessments of pain (at rest and with movement) and stiffness. Approximately 42% of women had residual impairment of at least one type one year after surgery, the most common problems being pain (16%) and reduced grip strength (16%). Except for lymphedema, measurements one year after surgery showed little change from measurements at 6 months, suggesting that the shorter follow‐up may be appropriate for assessing the long term effects of axillary dissection. Lymphedema was the only sequela which increased over time. The results provide parameter estimates for designing studies to evaluate the role of physiotherapy after axillary dissection. © 1992 Wiley‐Liss, inc.
Melanocyte chemotactic factor produced by skin metastases of a breast carcinoma
Authors: Konomi Kohki , Imayama Shuhei , Nagae Shonosuke , Terasaka Reiji , Chijiiwa Kazuo , Yashima Yutaka 
Published: February 2007

AbstractA 65‐year‐old woman underwent right modified radical mastectomy for a malignant lesion which had developed just below the right nipple. Two years after the operation, skin lesions composed of dark brown to black, pigmented, papular lesions developed in the precordia. A biopsy revealed this to be a cutaneous metastasis of the previous breast carcinoma. However numerous pigment blockade melanocytes were also found in the tumor nests, located in and/or beneath the epidermis. Although a black‐colored breast carcinoma has been reported, the presence of pigment blockade melanocytes was not determined. Culture of the tumor nest recovered a population of melanocytes as well as the carcinoma cells. Boyden chamber analysis revealed the presence of a chemotactic factor for melanocytes in the culture medium. This seems to be the first documentation of melanocyte incorporation in breast carcinoma tissue. © 1992 Wiley‐Liss, Inc.
Sphincter‐preserving extended resection for locally advanced rectosigmoid carcinoma involving the urinary bladder
Authors: Fuhrman George M. , Talamonti Mark S. , Curley Steven A. 
Published: February 2007

AbstractRadical en bloc resection has gained acceptance in the management of locally advanced colorectal carcinoma. Total pelvic exenteration has been advocated as treatment for rectosigmoid cancers involving adjacent genitourinary structures. We report a series of 10 patients who underwent total cystectomy with en bloc segmental colorectal resection and restoration of intestinal continuity. All margins, including the distal colorectal margin of resection, were pathologically uninvolved by tumor. The median follow‐up on these patients was 44 months and the mean survival was 42.5 months. The local recurrence rate (20%) and survival rates are comparable to those in reports describing pelvic exenteration for colorectal cancer. Our patients had normal postoperative bowel function. An extended colorectal resection, including a total cystectomy with rectal sphincter preservation, is occasionally possible when tumor‐negative resection margins can be achieved. By restoring intestinal continuity, such an operation provides an improved quality of life, and more importantly, fulfills the criteria for an oncologically sound operation. © 1992 Wiley‐Liss, Inc.
The diagnostic significance of gastrin measurement of bronchoalveolar lavage fluid for lung cancer
Authors: Zhou Qinghua , Yang Zhenhua , Yang Junjie , Tian Zipu , Zhang Huaibin 
Published: February 2007

AbstractIn this study, determination of gastrin concentration in bronchoalveolar lavage fluid and serum has been detected by radioimmunoassay in 30 cases of lung cancer and 24 cases of non‐cancer pulmonary diseases. The results show that the gastrin concentration and its positive rate of lavage fluids from cancer lung are much higher than those from healthy lung and serum in lung cancer patients, and those from serum and both disease and healthy lung in non‐cancer pulmonary disease patients (P < 0.01). The gastrin ratio of lavage fluids from cancer lung to serum is also significantly higher than the ratio of lavage fluid from healthy lung to serum and all the ratios in the non‐cancer pulmonary disease group. These results suggest that there is a high gastrin concentration in local tissue of lung cancer, which is signified by the high concentration of gastrin and its high positive rate in lavage fluids from the lung with cancer. Therefore, the gastrin determination in lavage fluids and gastrin ratio of lavage fluids to serum are more reliable in the differential diagnosis of benign from malignant pulmonary diseases than gastrin determination of serum alone. © 1992 Wiley‐Liss, Inc.
Biodistribution of monoclonal antibody A7 and its F(ab′)2 fragment in athymic nude mice bearing human pancreatic carcinoma
Authors: Otsuji Eigo , Yamaguchi Toshiharu , Yamaoka Nobuki , Yamaguchi Nozomi , Imanishi Jiro , Takahashi Toshio 
Published: February 2007

AbstractXenografts of a human pancreatic carcinoma cell line, HPC‐YS, which reacted with the monoclonal antibody (MAb) A7, were used to investigate the in vivo localization of radioiodinated MAb A7 after intraperitoneal injection. MAb A7 localized to the tumor 4 days and 8 days after injection with a tissue/blood ratio of 1.45 ± 0.18 and 2.04 ± 0.20, respectively. The accumulation of MAb A7 in the tumor was 5%/g and 3.3%/g of the injected dose on day 4 and on day 8, respectively. In contrast, the F(ab')2 fragment of MAb A7 localized to the tumor 4 days after intravenous injection with a tissue/blood ratio of 14.2. The accumulation of the F(ab')2 fragment in the tumor was 1.2%/g of the injected dose. These results suggested that MAb A7 might be a suitable carrier of anticancer drugs for immunotargeting chemotherapy and that the F(ab')2 fragment might be potentially useful for the immunodetection of human pancreatic carcinomas. © 1992 Wiley‐Liss, Inc.
Adenocarcinoma of the urachus
Authors: Ravi R. , Shrivastava B. R. , Chandrasekhar G. M. , Prahlad Sarojini , Balasubramanian K. V. , Mallikarjuna V. S. 
Published: February 2007

AbstractDuring the past 5 years, three patients with adenocarcinoma of the urachus were treated at our hospital. Abdominal ultrasonography helped clinch the diagnosis in all cases. All patients underwent surgical excision of the neoplasm with partial cystectomy. The clinical, radiological, and histological findings, as well as the pathogenesis of this rare neoplasm are discussed along with the surgical management. © 1992 Wiley‐Liss, Inc.
The use of the saddle prosthesis for reconstruction of the hip joint after tumor resection of the pelvis
Authors: Van Der Lei Berend , Hoekstra Harald J. , Veth Rene P. H. , Ham S. John , Oldhoff Jan , Koops Heimen Schraffordt 
Published: February 2007

AbstractReconstruction of the hip joint by a saddle prosthesis after excision of a malignant pelvic tumor is a relatively new method, which thus far has been mainly used for revision of infected hip arthroplasties. One patient with a metastatic cystosarcoma phyllodes and one patient with a chondrosarcoma of the pelvis were treated by local resection and reconstruction with a saddle prosthesis. Although the patient with the metastatic cystosarcoma phyllodes died 9 months after surgery due to metastatic disease, both patients had early recovery, with no difference in leg length and obtained early painless complete weight bearing with satisfactory functional result. These two case reports clearly illustrate the usefulness of the saddle prostheses in limb saving surgery for malignant tumors of the pelvis. © 1992 Wiley‐Liss, Inc.
Postoperative atrial fibrillation in cancer surgery: Preoperative risks and clinical outcome
Authors: Gibbs Harry R. , Swafford Joseph , Nguyen Hoang D. , Ewer Michael S. , Ali Mohamed K. 
Published: February 2007

AbstractPostoperative atrial fibrillation (AF) is a recognized complication of cancer surgery. The purpose of this study was to define preoperative risk factors for AF, and to evaluate the clinical significance of the arrhythmia. We reviewed the medical records of 43 patients with postoperative AF admitted to the surgical intensive care unit (SICU). All patients were older than 60 years, 79% had a history of cigarette smoking, and 44% had hypertension. AF occurred an average of 2.8 days following surgery, and lasted an average of 2.1 days. No significant complications developed, and there were no long‐term sequelae. This study suggests that, in cancer patients, postoperative AF is a disease of elderly patients. In addition the arrhythmia appears to be a relatively transient and benign phenomenon. Prolonged monitoring in an intensive care setting may not be necessary for asymptomatic, hemodynamically stable patients. © 1992 Wiley‐Liss, Inc.
Cisplatin plus VP‐16 combination chemotherapy in advanced refractory breast cancer
Authors: Içli Fikri , Güunel Nazan , Dinçlol Dilek , Karaoǧuz Handan , Demirkazik Ahmet 
Published: February 2007

AbstractTwenty‐nine patients with advanced refractory breast cancer were treated with cisplatin 20 mg/m2/d and VP‐16 100 mg/d for 5 days every 3–4 weeks. Ten patients received mitomycin C 10 mg/m2 every 6 weeks additionally. Partial response was obtained in 10 of 26 evaluable patients (38%). The response rates for the group treated with and without mitomycin C were 40% and 37.5%, respectively. Median response duration was 5.5 months in partial responders. Median survival was 9.5 months for partial responders and 2 months for the rest of the patients. Cisplatin and VP‐16 combination can be considered as a salvage treatment in heavily pretreated patients with advanced breast cancer. © 1992 Wiley‐Liss, Inc.
En bloc caudate lobe and partial vena cava resection using a gott shunt for retrohepatic caval bypass
Authors: Gardner Bernard , Bender Scott , Praeger Peter I. 
Published: February 2007

AbstractA technique of retrohepatic inferior vena cava bypass is described, useful for resection of the hepatic caudate lobe. A 77 year old female developed a solitary metastatic tumor mass in the caudate lobe compressing the Inferior Vena Cava (IVC), with cavography showing the IVC to be compressed, but patent. Without evidence of other metastatic disease radical resection of this tumor was performed. Successful resection was accomplished using a Gott shunt and porta hepatus compression for hepatic vascular isolation. No pump was used to avoid heparinization. Postoperative imaging confirmed IVC patency. The serum carcinoembryonic antigen (CEA) level fell to normal and remained so for 18 postoperative months. This introduces a new use of an atriocaval shunt for hepatic isolation during resection. © 1992 Wiley‐Liss, Inc.
Pre‐ and postoperative sequential study on the serum gastrin level in patients with lung cancer
Authors: Zhou Qinghua , Zhang Huaibin , Pang Xiaojie , Yang Junjie , Tain Zipu , Wu Zhu , Yang Zhenhua 
Published: February 2007

AbstractSerial changes in serum gastrin level were detected by radioimmunoassay in 58 lung cancer patients before and after operation. In comparing these tests with those of 40 cases of noncancerous thoracic lesions and 151 normal adults, the serum gastrin from lung cancer patients is significantly higher than that of noncancerous thoracic lesions and normal individuals (P < 0.01). The gastrin level is closely related to stage of cancer, size of primary tumor, presence of lymph node metastasis, and type of histological classification. The serum gastrin was found to decrease gradually after the removal of the tumor and to return to normal on the 14th postoperative day. Those patients whose serum gastrin level can return to normal on the 14th postoperative day will have a good prognosis; if not, their prognosis will be very poor. These results suggest that serum from patients with lung cancer contains a high concentration of gastrin that can help differentiate benign from malignant thoracic lesions and evaluate prognosis of patients with lung cancer. Therefore, the cause of high serum gastrin in patients with lung cancer is likely due to the gastrin‐producing property of the lung cancer cells. © 1992 Wiley‐Liss, Inc.
Targeting cancer chemotherapy using a monoclonal antibody (NCC‐LU‐243) conjugated with mitomycin C
Authors: Kubota Tetsuro , Yamamoto Takaaki , Takahara Tetsuya , Furukawa Toshiharu , Ishibiki Kyuya , Kitajima Masaki , Shida Yasui , Nakatsubo Hiroshi 
Published: February 2007

AbstractTwo kinds of immunoconjugate (T‐3M and T‐11M) of murine monoclonal antibody with mitomycin C (MMC) were developed using spacers containing a disulfide (T‐3M) or thiocarbamate (T‐11M) bond. A murine monoclonal antibody (NCC‐LU‐243) raised against a human small cell lung carcinoma cell line, Lu‐24, in nude mice, is an IgG2a monoclonal antibody that recognizes a 145‐kDa protein on the cell surface membrane. T‐3M and T‐11M showed affinity for the LU‐243 antigen‐positive H‐69 cell line but not for the antigen‐negative Lu‐65 cell line in vitro. In the in vitro MTT assay, the order of efficacy of these compounds was T‐11M>T‐3M>MMC against antigen positive H‐69 and T‐11M = MMC>‐3M against antigen‐negative K562. When antigen‐positive H‐69 was transplanted into nude mice for in vivo assay, the maximum tolerated dose of T‐3M was twice as high than that of the parent compound MMC. Furthermore, T‐3M showed higher antitumor activity against antigen‐positive H‐69 than MMC conjugated with a non‐specific rabbit IgG in vivo. When the maximum tolerated doses of T‐3M and MMC were administered to H‐69‐bearing nude mice, the effect of T‐3M was superior to that of MMC, whereas no differences were observed between the antitumor activity of T‐3M and MMC against antigen‐ negative MX‐1, a human breast carcinoma. These two immunoconjugates of monoclonal antibody with mitomycin C are thought to be useful for targeting cancer chemotherapy against human small cell lung carcinomas. © 1992 Wiley‐Liss, Inc.
Surgical treatment for thoracic esophageal carcinoma in patients after gastrectomy
Authors: Kato Hoichi , Tachimori Yuji , Watanabe Hiroshi 
Published: February 2007

AbstractThe clinicopathologic factors in 50 gastrectomized and 831 nongastrectomized patients with thoracic esophageal carcinoma were compared. The differences in various factors were not statistically significant except for the average duration of operation, which suggests that the association of esophageal carcinoma and previous gastrectomy is a chance finding. Thirty‐four gastrectomized patients underwent abdominal lymphadenectomy and 16 did not. The postoperative survival curves for the two groups did not differ. In comparing the clinicopathologic factors between the two groups, only the tumor location differed significantly (P< .05). Nine patients (26.5%) with lesions in the mid‐ or lower thoracic esophagus in the gastrectomized group had positive nodes in the abdomen; the 5‐year survival rate was 39.4%. Among them, 8 had gastrectomy for peptic ulcer. Abdominal lymphadenectomy is recommended for those patients with mid‐ or lower thoracic esophageal carcinoma who have had previous gastrectomy without lymphadenectomy. © 1992 Wiley‐Liss, Inc.
Hepatic resection for a hepatocellular carcinoma larger than 10 cm
Authors: Furuta Toshiya , Sonoda Takashi , Matsumata Takashi , Kanematsu Takashi , Sugimachi Ano Keizo 
Published: February 2007

AbstractTwenty‐one patients with hepatocellular carcinoma (HCC) larger than 10 cm diameter were treated during the 18year period from 1971 to 1988. The mean tumor size was 13 cm (range 10–18 cm). Nineteen patients (90.5%) had subjective symptoms. Eight patients (38.1%) had alpha‐fetoprotein (AFP) levels over 10,000 ng/ml, and in 18 patients (85.7%) the levels were over 20 ng/ml. Nevertheless, only three (14.3%) were detected by AFP. Scintigraphy before 1981 and ultrasonography after 1982 appears to be most helpful for detection of HCC. Nineteen lesions (90.5%) were localized in the right hepatic lobe. Large HCC showed a low incidence of histologically verified concomitant cirrhosis (33%; 7 of 21) and a relatively well preserved hepatocellular function (indocyanine green test; 13.9 ± 6.6%). Curative resection could be done for all 21 patients. There were three (14.3%) operative deaths. The 1‐, 3‐, and 5‐year survival rates were 72.2, 32.9, and 8.2%, respectively. One patient who underwent a left hepatic lobectomy has survived for over 5 years, with recurrence. There were 14 recurrences (66.7%) in 21 patients: 11 were hepatic and three were in the lungs. In patients with large HCC, surgical resection shoald be done, provided the clinical status and hepatocellular reserves are adequate. © 1992 Wiley‐Liss, Inc.