bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rethinking Coiled Tubing String Lifespan Assessment: Leveraging Frequent Inspections for Enhanced Operational Insights
Authors: Rath B. , Watson B. , Glanville Joel 
Published: March 2024

Abstract
Traditionally, the industry benchmark for determining the lifespan of a coiled tubing string has relied on conventional parameters like running meters or fatigue analysis. This study will highlight the benefits of utilizing frequent coiled tubing string inspections as a key factor in assessing the effective remaining operational life of coiled tubing strings. The study aims to provide valuable insights that can enhance decision-making in asset management and maintenance procedures.
A sample of coiled tubing strings across various operational environments underwent inspections at key intervals during their respective operational lifespans. Rigorous inspection protocols were implemented, capturing data on factors like corrosion, material degradation, and stress-induced deformities. A comparative analysis was conducted using historical data obtained from running meters and fatigue analysis to highlight the unique insights provided by frequent inspections.
The findings of this study underscore the significance of frequent string inspections in assessing the operational lifespan of coiled tubing strings. While traditional methods such as running meters and fatigue analysis remain informative, they often overlook localized stressors and gradual deterioration that can compromise string integrity. In contrast, frequent inspections offer insights into the evolving condition of the strings, enabling timely interventions to prevent catastrophic failures. Furthermore, the data collected from frequent inspections can be utilized in an effective manner to anticipate future wear patterns and potential failure points. This proactive approach to maintenance and asset management enhances operational efficiency, reduces downtime, and optimizes resource allocation.
This study sheds light on a significant departure from the traditional industry practice of assessing the lifespan of a coiled tubing string through conventional means. Shifting the service industry's focus toward frequent inspections as a new perspective for assessing coiled tubing string lifespan holds positive implications for asset management and maintenance strategies. By embracing this approach, service companies can make more informed decisions about when to replace or repair coiled tubing strings, ultimately prolonging their service life and minimizing operational disruptions.
Complex Coiled Tubing Fishing Operation of Slickline Tools with No Kill Fluid in the Well in Danish North Sea
Authors: Kaul K. , Jari A. , Blanckaert T. 
Published: March 2024

As part of offshore workover operations in the Danish North Sea to safeguard the future of producing oil wells, older completions are being changed to new 5 in Glass Reinforced Epoxy (GRE) lined completions using workover rigs. During one of the several phases of this operation in one of these wells, slickline (SL) was being used to remove scale using a bailer when the Bottom Hole Assembly (BHA) got stuck and lost in the well. The wire was pulled to 70% of its breaking strength of 2150 lb with no indication of the SL jar firing. The fish left in the wellbore was a 37 ft long tool consisting of a roller stem, spang jar, and a 3 in pump bailer assembly. The top fishing point was a 1.75 in fish neck rope socket, with the top of the fish at 7219 ft.
This horizontal oil producer was first drilled and completed in 2001 using a jack-up rig over a platform.
The job objective for Coiled Tubing (CT) was to return the well to the original workover plan by safely fishing the lost BHA while considering the following conditions:
The fishing tool combined with the fish would be too long for the available lubricator length. The hydrostatic pressure of the existing well fluid would be insufficient to overcome the reservoir pressure. A pressure-tested barrier is present between the casing and tubing annulus. The deep-set plug installed in the tubing at ~7350 ft has been pressure and inflow tested to 2900 psi.
The Role and Benefits of Intervention-Based Production in the Energy Transition and the Drive to Net Zero
Authors: Billingham M. 
Published: March 2024

Abstract
This work is an effort to quantify the CO2 production reduction with intervention-associated production. A brief summary of possible savings has been presented (Billingham et al. 2023). There is a global drive to reduce CO2 production to meet net zero ambitions and limit global warming. Fossil fuels, including oil and gas, have been shown to be a major contributor to CO2 emissions leading to an ongoing drive for energy transition to "greener" energy sources. Within this scenario, however, world energy demand continues to increase with a significant percentage of the world's population in a state of energy poverty. The growth of green-based new energy is significant but alone will not be able to meet the world's near-term energy requirements. As such, oil and gas will remain an important energy source in the near to mid-term future.
To maintain and increase production there are two avenues, these being the drilling of new wells or the reduction in the decline of production in existing fields, which ideally will include increases in recovery factors. The industry states that the latter approach delivers the cheapest production with the lowest carbon footprint. It makes sense that the improved utilization of existing infrastructure can deliver this, and the associated cost of production has been quantified before (Billingham et al. 2023). This work assesses intervention-associated production techniques to quantify the CO2 production reduction associated with this production.
Beginning with a high-level perspective evaluating rig-based new well production increases compared to agile interventions, the work then assessed specific technologies and methods that can deliver the desired outcomes. For example, it has been estimated that using a lightweight intervention vessel (LWIV) could reduce the associated CO2 production by 80% when compared to performing the same activity from a modular drilling unit (MODU). Opportunity for further improvements were also investigated.
Operators have the challenge of meeting global energy demand and their net-zero ambitions. Intervention-based production should be an enabler in achieving this balance. This work will serve as an industry reference as to the benefits of intervention-based production during the ongoing energy transition and why it should be a key focus.
Investigating the Impact of Hydrocarbon Solvent on In-Situ Asphaltene Precipitation in Solvent-Assisted Cyclic Steam Technique
Authors: Rahnema Hamed , ElMasry Aly , Rahnema Milad 
Published: March 2024

Summary
Heavy oil recovery techniques often confront a significant challenge in in-situ asphaltene precipitation. This procedure significantly affects the characteristics of reservoirs and impedes optimal oil extraction. The purpose of this research was to examine how hydrocarbon solvents affect asphaltene precipitation occurring naturally in the reservoir as well as the resulting asphaltene content in processed oil. This was conducted using a laboratory-level dynamic model and the solvent-assisted cyclic steam stimulation (CSS) method. Throughout this experiment, which comprised six cycles, the steam-solvent blend’s pressure was consistently maintained close to 680 psi and the temperature was maintained at 500°F at the injection point. The findings revealed crude oil cracking at this temperature and noticeable in-situ asphaltene precipitation during the solvent-assisted CSS process. Notably, asphaltenes demonstrated mobility within porous media, contributing to their production in subsequent CSS cycles. Compared to a steam-only CSS control experiment, a higher asphaltene content in the original oil was observed, indicating that thermodynamic changes during the experiments likely caused asphaltene cracking. To sum up, this research provides an understanding of the effects of heavy oil recovery methods that rely on solvents on the precipitation of in-situ asphaltene and the content of asphaltene in the refined oil.
Designing a Data Mining-enabled Case-based System for Tuberculosis Diagnosis
Authors: Indebu Irandufa , Meshesha Million , Mohemmed Wesenu 
Published: March 2024

Abstract

Tuberculosis remains a persistent public health problem in Ethiopia, which demands innovative solutions for diagnosis and treatment support. Knowledge-based systems, particularly case-based systems, offer valuable decision-making assistance for various diseases. This paper introduces a data mining-driven approach for automatic knowledge extraction to develop a case-based system for tuberculosis diagnosis. Hidden insights are extracted from a tuberculosis dataset through the hybrid knowledge discovery process. The collected data set is pre-processed to fill in missing values, correct outliers, and remove noise. Clustering techniques, such as K-means, Make Density-based clustering, and farthest first, are employed to construct a descriptive model. The K-means algorithm is selected for its superior performance. Integration of the descriptive model into a case-based system is done using a Java-based integrator module. The prototype case-based system demonstrates an accuracy of 90%, which is a promising result. Further work is required to integrate the case-based system with rule-based towards developing a generic knowledge-based system.
Assessment of Soil Moisture during landslide over a hilly region: A Case Study
Authors: Fatima Hashmi , Sreevat Raghavendra , Mohandas Saji , Prasad V. S. 
Published: March 2024

Abstract
Landslides are one of the common geological hazards in the hilly regions throughout the world. Other than geological, morphological and anthropogenic causes, precipitation is the most common triggering factor for the occurrence of landslides. Rainfall-induced landslides are the result of the combined action of precipitation on topography, geology, soil and vegetation. Soil moisture and rainfall are intervened with each other. Forecasting landslides based on soil moisture is very difficult because mainly other geological and geomorphological parameters play quite a dominant role. However, in this study we analyse the soil moisture before and during landslides at three places (Solan, Shimla, Mandi) in Himachal Pradesh, India, which happened on 14 august 2023 after heavy rainfall. This study compares the various models, observations and reanalysis datasets available and assesses the various components of hydro-meteorological factors leading towards potential prediction of landslides. Model forecast is predicting an increase in soil moisture for the day when landslide occurred; therefore soil moisture forecast can be used in landslide early warning system.
Contextual analysis of cervical cancer prevention policies in Iran: A Leichter-based model
Authors: Pirani Narges , Akrami Forouzan , Jafari Mehdi , Pirani Hadis , safari Hossein , EbadiFardAzar Farbod , Doshmangir Leila 
Published: March 2024

Abstract
Background: Cervical cancer is considered the fourth most common type of cancer among women worldwide. The prevalence of this cancer is also increasing in Iran. This study aimed to conduct a context analysis of Iran's health policy concerning cervical cancer prevention.
Methods: In this qualitative study, data was collected through semi-structured interviews between July 2020 and September 2021. The sample consisted of 43 individuals, purposefully chosen to represent faculty members, researchers, policymakers, health insurance administrators, personnel of community health centers, and service users. The data underwent analysis using the framework analysis method, in accordance with the Leichter model, with the aid of MAXQDA2020 software.
Results: Due to the increasing incidence of cervical cancer and the growing international advocacy, a policy opportunity has arisen to focus policymakers' attention on preventing cervical cancer in Iran. The main challenges to implementing these policies are conflicts of interest, a poorly organized referral system, inadequate financial assistance for vulnerable groups, low public awareness, and inconsistent guidelines.
Conclusion: Overall, the findings highlight the need for comprehensive approaches to address cervical cancer in Iran. Such measures should emphasize elevating public awareness, encouraging human papillomavirus (HPV) vaccination, providing financial assistance for the cancer control plan, and supporting at-risk populations.
Analgesic Effectiveness of Wound Infiltration with Bupivacaine Versus a Mixture of Bupivacaine with Tramadol for Postoperative Pain Management Among Parturients Undergoing Elective Cesarean Section Under Spinal Anesthesia at Dilla University Referal Hospital, 2023: A Double-Blind Randomized Controlled Trial
Authors: Milkias Mesay , Mekonnen Semagn , Aweke Zemedu , Getachew Hailemariam , Mulugeta Hailemariam , Kebede Melkamu , Destaw Belete , Melese Medhanit , Ahmed Siraj 
Published: March 2024

Abstract

Background
Post-cesarean pain is among the principal problems with an incidence rate ranging from 25.5 to 80%. A variety of pain managing approaches have been used over the years, to manage post-cesarean pain, but none of them were free of adverse effects. Wound infiltration is a simple and feasible approach to managing post-cesarean pain. Despite its simplicity, the effectiveness of wound infiltration with a mixture of bupivacaine and tramadol is still unknown.
Objective
The study aims to compare the analgesic effectiveness of wound infiltration with bupivacaine versus a combination of bupivacaine with tramadol for postoperative pain management among parturients undergoing cesarean section under spinal anesthesia.
Methodology:
A double-blind, superiority-based, parallel, randomized controlled trial was conducted on 60 parturients. Parturients were randomized to take either bupivacaine (B = 30) or a combination of bupivacaine and tramadol (BT = 30). The homogeneity of variance was examined using Levine's test, and the normality was assessed using Shapiro-Wilk. The independent t-test and the Manny Whitney U test were used, respectively, for Parametric and non-parametric data. To assess the repeated measurements, a mixed linear model and general estimating equations were used. A p-value of below 0.05 is taken as Statistically significant.
Result
Totally 60 parturients were analyzed and no dropouts. The severity of pain in the 6th hour is 6 times greater in the B group in comparison to the BT Group (P = 0.001, OR = 6.289, CI = 2.097–18.858). The mean tramadol consumption was lesser in the BT group (140.00 ± 48.066 mg) than B group (175.00 ± 34.114 mg) min with a statistically significant mean difference of 10.761 (95% CI, 13.459 to 56.541), t (58) = 3.252, P = 0.002, (d = 0.839). The mean first analgesia request was higher in a mixture of tramadol and bupivacaine group, (Mean ± SD) (367.33 ± 50.099 min) than bupivacaine group (216.33 ± 68.744 min) with a statistically significant difference of 15.530 (95% CI, -182.087 to -119.913), t (58) = 5.6553, P = 0.001.
Conclusion and recommendation:
Wound infiltration with a combination of bupivacaine and tramadol is more effective than bupivacaine alone for postoperative analgesia for pregnant patients who underwent cesarean delivery under spinal anesthesia.
Demonstration of an energy-efficient Ising solver composed of Ovonic Threshold Switch (OTS)-based nano-oscillators (OTSNOs)
Authors: Lee Young Woong , Kim Seon Jeong , Kim Jaewook , Kim Sangheon , Park Jongkil , Jeong YeonJoo , Kim Jaewook , Hwang Gyu Weon , Park Seongsik , Park Bae Ho , Lee Suyoun 
Published: March 2024

Abstract

As there is an increasing need for an efficient solver of combinatorial optimization problems, much interest is paid to the Ising machine, which is a novel physics-driven computing system composed of coupled oscillators mimicking the dynamics of the system of coupled electronic spins. In this work, we propose an energy-efficient nano-oscillator, called OTSNO, which is composed of an Ovonic Threshold Switch (OTS) and an electrical resistor. We demonstrate that the OTSNO shows the synchronization behavior, an essential property for the realization of an Ising machine. Furthermore, we have discovered that the capacitive coupling is advantageous over the resistive coupling for the hardware implementation of an Ising solver by providing a larger margin of the variations of components. Finally, we implement an Ising machine composed of capacitively-coupled OTSNOs to demonstrate that the solution to a 14-node MaxCut problem can be obtained in 40 ms while consuming no more than 2.3 mJ of energy. Compared to a previous hardware implementation of the phase-transition nano-oscillator (PTNO)-based Ising machine, the OTSNO-based Ising machine in this work shows the performance of the increased speed by more than one order while consuming less energy by about an order.
Exposure to gestational diabetes mellitus in utero impacts hippocampal functional connectivity in response to food cues in children
Authors: Kullmann Stephanie , Zhao Sixiu , Semeia Lorenzo , Veit Ralf , Luo Shan , Angelo Brendan , Chow Ting , Birkenfeld Andreas , Preissl Hubert , Xiang Anny , Page Kathleen 
Published: March 2024

Abstract

Objectives
Intrauterine exposure to gestational diabetes mellitus (GDM) increases the risk of obesity in the offspring, but little is known about the underlying neural mechanisms. The hippocampus is crucial for food intake regulation and is vulnerable to the effects of obesity. The purpose of the study was to investigate whether GDM exposure affects hippocampal functional connectivity during exposure to food cues using functional magnetic resonance imaging.
Methods
Participants were 90 children age 7–11 years (53 females) who underwent an fMRI-based visual food cue task in the fasted state. Hippocampal functional connectivity (FC) was examined using generalized psychophysiological interaction in response to high-calorie food versus non-food cues. Food-cue induced hippocampal FC was compared between children with and without GDM exposure, while controlling for possible confounding effects of age, sex and waist-to-hip ratio.
Results
Children with GDM exposure exhibited stronger hippocampal FC to the insula and striatum (i.e., putamen, pallidum and nucleus accumbens) compared to unexposed children, while viewing high caloric food cues.
Conclusions
Intrauterine exposure to GDM was associated with higher food-cue induced hippocampal FC to reward processing regions. Future studies with longitudinal measurements are needed to clarify whether increased hippocampal FC to reward processing regions may raise the risk of the development of metabolic diseases later in life.
Genomic-transcriptomic analysis reveals Syrian hamster as a superior human disease animal model
Authors: Wang Yaohe , Wang Chuchu , Cheng Zhenguo , Miao Jinxin , Xue Xia , Dong Yunshu , Zhao Li , Guo Haoran , Wang Jianyao , Wang Zhizhong , Lu Shuangshuang , Zhang Zhongxian , Gao Dongling , Wang Zhimin , Wang Pengju , Fang Guangming , Peng Ying , Zhai Yafei , Zhang Lirong , Dunmall Louisa , Wang Jun , Tang Wenxue , Li Xiaowei , Ding Zhongren , Zhao Xiaoyan , Li Ling , Lemoine Nicholas , Tang Wenjie , Tonge Daniel , Wang Zhongde , Dong Jianzeng 
Published: March 2024

Abstract
Backgroud: The Syrian hamster (Mesocricetus auratus) has shown promise as a human diseases model, recapitulating features of different human diseases including the emerging COVID-19. However, the landscape of its genome and transcriptome has not been systematically dissected, restricting its potential applications.
Results: Here we provide a complete analysis of the genome and transcriptome of the Syrian hamster and found that its lineage diverged from that of the Chinese hamster (Cricetulus griseus) around 29.4 million years ago. 21,387 protein-coding genes were identified, with 90.03% of the 2.56G base pair sequence being anchored to 22 chromosomes. The further comparison of the transcriptomes from 15 tissues of the Syrian hamster disclosed that Syrian hamster shares a pattern of alternative splicing modes more similar to humans, compared to rats and mice. A integrated genomic-transcriptomic analysis revealed that Syrian hamster also has genetic and biological advantages as a superior animal model for cardiovascular diseases. Strikingly, several genes involved in SARS-COV-2 infection including ACE2present a higher homology with humans than other rodents and show the same function as the human counterparts.
Conclusion: The detailed molecular characterisation of the Syrian hamster in the present study opens a wealth of fundamental resources from this small rodent for future research into human disease pathology and treatment.
Nicotinic acid suppresses liver cancer metastasis via histone lysine nicotinylation
Authors: Zhang Hong-Quan , Jiang Yuhan , Li Yixiao , Zhang Lei , Yan Haoyi , Qin Ziheng , Li Qianchen , Peng Yidi , Liu Jia , Weng Yejing , Cheng Zhongyi , Lv Danyu , Zhang Jing , Tang Yan , Zhan Jun 
Published: March 2024

Abstract
Vitamin B3 is the major precursor of NAD+ and NADP+, however it was unknown whether this vitamin supplementation could modify histone epigenetically. Here, we report nicotinic acid (NA), a component of vitamin B3, suppresses liver cancer metastasis specifically, via stimulating histone lysine nicotinylation (Knic). Importantly, nicotinyl-CoA, that metabolically generated by NA via ACSS2, stimulates histone Knic in vivo and in vitro. Histone Knic regulates chromatin accessibility and inhibits binding of transcription factor HOXB9 to the promoter of oncogene PPFIA1, resulting in inhibition of hepatocyte carcinoma progression. Notably, we found that NA specific induces histone Knic and suppresses hepatocyte carcinoma progression, whereas nicotinamide, an amide form of nicotinic acid, does not stimulate nicotinylation, instead promotes tumour growth and metastasis. These findings suggest that vitamin B3 supplementation may contribute to cancer progression depending on its composition. Collectively, we demonstrated that histone lysine nicotinylation is a histone mark controlling gene expression and NA supresses liver cancer progression by inducing histone lysine nicotinylation.