bluuebunny/crossref_metadata_2025_split huggingface dataset:
The lesion detection rate of Ga‐68 DOTATATE PET/MR in multiple endocrine neoplasia type 1
Authors: Gao Jing , Liu Chang , Zhou Jinxin , Pan Yu , Zhang Yifan 
Published: April 2024

AbstractIntroductionThe purpose of the study was to determine the usefulness of Ga‐68 DOTATATE PET/MR in the identification of tumours in individuals with multiple endocrine neoplasia type 1 (MEN1).MethodsIn this retrospective investigation, five individuals who had tested positive for a hereditary MEN1 variant underwent Ga‐68 DOTATATE PET/MR between May 2020 and January 2023. Several types of tumours associated with MEN1 were studied. MEN1‐related tumours included pituitary, parathyroid, gastroenteropancreatic, and adrenal. The rates of lesion identification between MRI, Ga‐68 DOTATATE PET, and Ga‐68 DOTATATE PET/MRI were examined. The maximum and mean standard uptake values (SUVmax and SUVmean) were evaluated in carefully delineated volumes of interest (VOI) for the relevant tumours.ResultsOf the 24 primary lesions, 14 were identified by Ga‐68 DOTATATE PET, 18 by MRI, and 20 by Ga‐68 DOTATATE PET/MRI. Two pituitary tumours were detected by all three techniques. All parathyroid tumours that were not detected by Ga‐68 DOTATATE PET and MRI were found by Tc‐99m MIBI SPECT/CT or/and EUS. Ga‐68 DOTATATE PET/MR detected more gastroenteropancreatic lesions. All adrenal tumours not identified by Ga‐68 DOTATATE PET were found by MRI or CT. The median SUVmax for lesions identified on Ga‐68 DOTATATE PET/MRI was 18.4 (range, 3.8‐85.2), and the median SUVmean was 12.0 (range, 2.3‐49.8).ConclusionThe combination of Ga‐68 DOTATATE PET and MRI demonstrated a higher detection rate and may be more useful in the work‐up of MEN1 providing a panoramic view of MEN1‐related lesions. To increase the identification of MEN1‐associated neuroendocrine lesions in the parathyroid gland, approaches other than Ga‐68 DOTATATE PET/MRI should be used.
A bibliometric analysis of miRNAs in rheumatoid arthritis from 2001 to 2022: Research hotspots and trends
Authors: Ma Xuezhi , Taxi Wumiti , Guo Yang , Jiaerken Hasiteer , Zhang Yafeng , Wang Jianwei , Sun Haitao , Wang Lining , Ma Yong 
Published: April 2024

AbstractBackgroundMicroRNAs (miRNAs) are widely recognized in the pathogenesis of autoimmune disease. As a key regulatory factor, miRNAs have introduced new biomarkers for the early diagnosis of rheumatoid arthritis (RA) and provided a favorable research direction for the development of novel therapeutic targets. This study aimed to explore the hotspots of miRNA research related to RA published from different countries, organizations, and authors.MethodsFrom 2001 to 2022, publications on miRNA related to RA were identified in the Web of Science database. The total and annual number of publishments, citations, impact factor, H‐index, productive authors, and involved journals were collected for quantitative and qualitative comparisons.ResultsA total of 29 countries/regions in the world have participated in the research of miRNAs and RA over the past two decades, and China (760, 53.18%) and the United States (233, 16.31%) account for the majority of the total publications. China dominated in total citation (17881) and H‐index (62). A total of 507 academic journals have published articles in related fields, and Frontiers in Immunology published the most (53, 3.71%). Chih‐hsin Tang of the China Medical University has published the most papers (16, 1.2%). Stanczyk (2008) published the most cited article Altered expression of miRNAs in synovial fibroblasts and synovial tissue in rheumatoid arthritis in Arthritis and Rheumatism, with 660 citations. Inflammation is the high‐frequency keyword outside of RA and miRNAs, and related researches have mainly focused on miR‐146a and miR‐155.ConclusionsIn the past two decades, extensive and continuous research has been conducted to investigate the role of miRNAs in RA, and miRNAs are widely recognized in the pathogenesis of RA. Related research has mainly focused on miR‐146a and miR‐155 that have shown promising results as key factors in RA experimental models. Focusing on clinical applications and translational research may be the future research direction and hotspot based on molecular biology basic research and mechanism exploration.
Risk factors for initial and recurrent severe infections in first hospitalized patients with systemic lupus erythematosus: A retrospective study of a Chinese cohort
Authors: Zhu Ying , Zhu Kexin , Zhang Xueyi , Qian Zhijie , Guo Qingqing , Xu Xuefeng , Yao Genhong , Tang Xiaojun , Wang Dandan , Zhang Huayong , Feng Xuebing , Jin Ziyi , Sun Lingyun 
Published: April 2024

AbstractObjectiveTo evaluate the incidence and associated factors of initial and recurrent severe infections in hospitalized patients with systemic lupus erythematosus (SLE).MethodsSLE patients that first hospitalized between 2010 and 2021 were studied retrospectively and divided into SLE with and without baseline severe infection groups. The primary outcome was the occurrence of severe infection during follow‐up. Cox regression models were used to calculate the hazard ratio (HR) and 95% confidence interval (CI) for initial and recurrent severe infections.ResultsAmong 1051 first hospitalized SLE patients, 164 (15.6%) had severe infection on admission. During a median follow‐up of 4.1 years, 113 (10.8%) patients reached severe infection outcomes, including 27 with reinfection and 86 with initial severe infection (16.5% vs. 9.7%, p = .010). Patients with baseline severe infection had a higher cumulative incidence of reinfection (p = .007). After adjusting for confounding factors, renal involvement, elevated serum creatinine, hypoalbuminemia, cyclophosphamide, and mycophenolate mofetil treatment were associated with an increased risk of severe infection, especially initial severe infection. Low immunoglobulin, anti‐dsDNA antibody positivity, and cyclophosphamide use significantly increased the risk of recurrent severe infection, with adjusted HR (95% CI) of 3.15 (1.22, 8.14), 3.60 (1.56, 8.28), and 2.14 (1.01, 5.76), respectively. Moreover, baseline severe infection and low immunoglobulin had a multiplicative interaction on reinfection, with adjusted RHR (95% CI) of 3.91 (1.27, 12.09).ConclusionIn this cohort of SLE, patients with severe infection had a higher risk of reinfection, and low immunoglobulin, anti‐dsDNA antibody positivity, and cyclophosphamide use were independent risk factors for recurrent severe infection.
Abusive supervision differentiation and work outcomes: An integrative review and future research agenda
Authors: Liang Yongyi , Yan Ming , Chen Yuanyi , Miao Chunchun 
Published: April 2024

AbstractAlthough the volume of literature on abusive supervision differentiation has increased in recent years, it remains a loosely organized body of work, with various conceptualizations, measurements, and contradictory opinions that create considerable confusion for future research. In this paper, we systematically review the conceptualizations and measurements and differentiate two levels of abusive supervision differentiation: abusive supervision dispersion at the group level and relative abusive supervision at the individual‐within‐group level. We then review the theoretical approaches and empirical findings on the consequences of abusive supervision dispersion and relative abusive supervision. Through this holistic review, we identify several conceptual and measurement issues associated with abusive supervision differentiation and find contradictory findings regarding the effects of abusive supervision differentiation. Accordingly, we propose a future research agenda that highlights the areas where additional research is needed to further our understanding of this topic. By doing so, we contribute to a more nuanced understanding of the complexity of abusive supervision differentiation and to the theoretical development of this subject.
Exploring the roles of compassion and post‐traumatic stress disorder on global distress after sexual trauma
Authors: Dawood Runa , Vosper Jane , Irons Chris , Gibson Stuart , Brown Gary 
Published: April 2024

AbstractObjectivesRecovery from sexual trauma can be complex and multi‐faceted. Most current psychological treatment protocols for trauma use a cognitive model of post‐traumatic stress disorder (PTSD). However, sexual trauma may include specific complexities beyond that of a cognitive model of PTSD, such as relational factors. The distress experienced after sexual abuse may involve variables not exclusive to a PTSD model. Compassion focused therapy (CFT) is an approach that incorporates evolutionary, relational and social perspectives. This study explored the relationships between variables associated with CFT, PTSD and distress in survivors of sexual abuse to determine the role of CFT‐related variables.Methods155 adults who had experienced sexual abuse or any unwanted sexual experience at any point in their lives completed online questionnaires pertaining to various CFT variables (self‐compassion, receiving compassion from others, having a fear of compassion from others, having a fear of compassion from the self, shame and self‐criticism) and questionnaires measuring global distress as the outcome of sexual abuse and PTSD symptoms.ResultsAn exploratory model involving CFT‐related variables explained significantly more of the variance (4.4%) in global distress than PTSD symptomology alone. Self‐criticism was found to be the variable with significant contribution.ConclusionsThat CFT treatments, targeting self‐criticism, should be developed alongside the standard cognitive model of PTSD based treatments for survivors of sexual abuse was supported. Future research may explore experimental designs utilizing CFT in this population, as well as further investigations on the roles of these specific CFT variables.
Identification of a marine‐derived sesquiterpenoid, Compound‐8, that inhibits tumour necrosis factor‐induced cell death by blocking complex II assembly
Authors: He Yuan , Yang Tingting , Li Jiao , Li Kaiying , Zhuang Chunlin , Zhang Meng , Li Ran , Zhao Yaxing , Song Qianqian , Jiang Mengyuan , Mao Shuichun , Song Xin‐gang , Guo Yufeng , Li Xuran , Tan Fei , Jitkaew Siriporn , Zhang Wen , Cai Zhenyu 
Published: March 2024

Background and PurposeTumour necrosis factor (TNF) is a pleiotropic inflammatory cytokine that not only directly induces inflammatory gene expression but also triggers apoptotic and necroptotic cell death, which leads to tissue damage and indirectly exacerbates inflammation. Thus, identification of inhibitors for TNF‐induced cell death has broad therapeutic relevance for TNF‐related inflammatory diseases. In the present study, we isolated and identified a marine fungus‐derived sesquiterpenoid, 9α,14‐dihydroxy‐6β‐p‐nitrobenzoylcinnamolide (named as Cpd‐8), that inhibits TNF receptor superfamily‐induced cell death by preventing the formation of cytosolic death complex II.Experimental ApproachMarine sponge‐associated fungi were cultured and the secondary metabolites were extracted to yield pure compounds. Cell viability was measured by ATP‐Glo cell viability assay. The effects of Cpd‐8 on TNF signalling pathway were investigated by western blotting, immunoprecipitation, and immunofluorescence assays. A mouse model of acute liver injury (ALI) was employed to explore the protection effect of Cpd‐8, in vivo.Key ResultsCpd‐8 selectively inhibits TNF receptor superfamily‐induced apoptosis and necroptosis. Cpd‐8 prevents the formation of cytosolic death complex II and subsequent RIPK1‐RIPK3 necrosome, while it has no effect on TNF receptor I (TNFR1) internalization and the formation of complex I in TNF signalling pathway. In vivo, Cpd‐8 protects mice against TNF‐α/D‐GalN‐induced ALI.Conclusion and ImplicationsA marine fungus‐derived sesquiterpenoid, Cpd‐8, inhibits TNF receptor superfamily‐induced cell death, both in vitro and in vivo. This study not only provides a useful research tool to investigate the regulatory mechanisms of TNF‐induced cell death but also identifies a promising lead compound for future drug development.
Artificial nail modelling systems in healthcare workers: An emerging risk of contact sensitization to a well‐known occupational allergen in an alternative way
Authors: Keskinkaya Zeynep , Işık Mermutlu Selda , Kaya Özge , Çakır Haile 
Published: April 2024

AbstractBackgroundArtificial nail modelling systems (ANMS) pose a significant risk for nail stylists and their clients regarding acrylate sensitization, which might jeopardize the use of acrylate‐containing medical devices.ObjectivesTo evaluate the frequency of artificial nail practices among female healthcare workers (HCWs) compared with controls and assess ANMS‐related side effects.MethodsIn this comparative, cross‐sectional, single‐centre study, a face‐to‐face interview with 200 female HCWs and 200 age‐matched female dermatology patients (controls) was conducted regarding the use of ANMS between March and November 2023.ResultsAmong 400 participants (median age: 25), 85 (21.3%) have applied ANMS at least once. The prevalence of ANMS application was significantly higher in HCWs (n = 54/200, 27%) compared with controls (n = 31/200, 15.5%) (p < 0.05). Long‐lasting nail polish was the most commonly preferred technique (n = 82/85, 96.5%). ANMS were mainly performed in nail studios by nail stylists (n = 79/85, 92.9%), while three participants were using home kits. Nail brittleness was the most frequently reported side effect (n = 19/85, 22.4%). No case of allergic contact dermatitis (ACD) was detected.ConclusionsThe popularity of ANMS among young female HCWs is growing. This striking trend might further put these individuals not only at risk of medical device‐related adverse events but also occupational ACD.
The roles of elevated temperature and carriers in the dyeing of polyester fibres using disperse dyes: Part 4 plasticisation model of dye diffusion
Authors: Burkinshaw Stephen M. 
Published: April 2024

AbstractThis review concerns the application of disperse dyes to poly(ethylene terephthalate) fibres using aqueous immersion dyeing processes and the roles of both elevated dyeing temperatures and carriers in the dyeing system. In this part of the paper, a novel plasticisation model of dye diffusion is proposed which reflects the crucially important mechanistic role that water‐induced fibre/polymer plasticisation adopts in the diffusion of disperse dyes within polyester and other types of polymeric material.
Improving sensitivity through data augmentation with synthetic lymph node metastases for AI‐based analysis of PSMA PET‐CT images
Authors: Trägårdh Elin , Ulén Johannes , Enqvist Olof , Edenbrandt Lars , Larsson Måns 
Published: April 2024

AbstractBackgroundWe developed a fully automated artificial intelligence (AI)AI‐based‐based method for detecting suspected lymph node metastases in prostate‐specific membrane antigen (PSMA)(PSMA) positron emission tomography‐computed tomography (PET‐CT)(PET‐CT) images of prostate cancer patients by using data augmentation that adds synthetic lymph node metastases to the images to expand the training set.MethodsSynthetic data were derived from original training images to which new synthetic lymph node metastases were added. Thus, the original training set from a previous study (n = 420) was expanded by one synthetic image for every original image (n = 840), which was used to train an AI model. The performance of the AI model was compared to that of nuclear medicine physicians and a previously developed AI model. The human readers were alternately used as a reference and compared to either another reading or AI model.ResultsThe new AI model had an average sensitivity of 84% for detecting lymph node metastases compared with 78% for human readings. Our previously developed AI method without synthetic data had an average sensitivity of 79%. The number of false positive lesions were slightly higher for the new AI model (average 3.3 instances per patient) compared to human readings and the previous AI model (average 2.8 instances per patient), while the number of false negative lesions was lower.ConclusionsCreating synthetic lymph node metastases, as a form of data augmentation, on [18F]PSMA‐1007F]PSMA‐1007 PETPET‐CT‐CT images improved the sensitivity of an AI model for detecting suspected lymph node metastases. However, the number of false positive lesions increased somewhat.
Differential expression and clinical significance of IGF2BP3 in peritoneal dialysate of patients with varying duration of peritoneal dialysis
Authors: Shao Xiaoqi , Yao Ling , Fu Jiao , He Mengmeng , Zhang Pei 
Published: April 2024

AbstractThis study aims to investigate the differential expression of insulin‐like growth factor 2 mRNA‐binding protein 3 (IGF2BP3) in the peritoneal dialysate among patients with different durations of peritoneal dialysis and its association with the angiogenic marker vascular* endothelial growth factor (VEGF), the fibronectin (FN), and various clinical indicators. A cohort of 122 peritoneal dialysis patients was categorized into short‐term (≤1 year, n = 33), mid‐term (>1 and ≤5 years, n = 55), and long‐term (>5 years, n = 34) groups based on dialysis duration. We utilized enzyme‐linked immunosorbent assay (ELISA) and western blot assays to quantify the levels of IGF2BP3, VEGF, and FN in the dialysate. Our findings showed a progressive increase in IGF2BP3 levels with the duration of PD, with the long‐term group exhibiting significantly higher levels than both the short‐term and mid‐term groups (p < 0.001). A positive correlation between IGF2BP3 and VEGF (r = 0.386, p = 0.013), as well as between IGF2BP3 and FN (r = 0.340, p = 0.030), was observed. IGF2BP3 levels also correlated positively with serum creatinine, calcium, and phosphorus levels. In vitro analysis further confirmed that IGF2BP3 expression is enhanced in human peritoneal mesothelial cells under high‐glucose conditions (p < 0.05). The study highlights the potential of IGF2BP3 in PD effluent as a biomarker for monitoring PF progression, with its expression significantly correlated with the duration of PD (Pearson r = 0.897, p < 0.001). In conclusion, our results underscore a correlation between elevated IGF2BP3 levels and PD duration, suggesting the clinical significance of IGF2BP3 as a biomarker for PF progression.
Acquired bleeding disorders
Authors: Tiede Andreas , Susen Sophie , Lisman Ton 
Published: April 2024

AbstractAcquired bleeding disorders can develop in previously healthy people irrespective of age or gender but are particularly common in patients with certain underlying conditions. Here, we review recent advances in the management of acquired haemophilia A (AHA), acquired von Willebrand syndrome (AVWS), and patients with hemostatic abnormalities due to chronic liver disease (CLD). Patients with AHA can now benefit from prophylaxis with emicizumab, a therapeutic antibody that mimics the function of activated coagulation factor VIII. The treatment of AVWS remains challenging in many situations and requires careful consideration of the underlying condition. Haemostatic abnormalities in CLD are often compensated by proportional reduction in pro and anti‐haemostatic factors resulting in sustained or even increased thrombin generation. Consequently, bleeding in CLD is rarely caused by haemostatic failure and infusion of plasma or coagulation factor concentrates may not be effective.
Advances and applications in water retention technology for meat and meat products: Status and future research directions
Authors: Ji Lili , Nie Qing , Zhou Yanan , Ning Jiawen , Wang Shu , Zhou Chunyan , Luo Yi , Yang Rui , Zhang Jiamin 
Published: March 2024

SummaryWater retention technology plays a critical role in enhancing the flavour and yield of meat products, as well as maximising the economic advantages of meat processing in contemporary practices. This technique enhances the economic viability of the firm by augmenting the texture profile of meat products and optimising the yield. Water retention approaches essentially encompass the manipulation of pH levels, the inhibition of protein oxidation denaturation, and the alteration of the micro‐spatial structure of muscles. This study reviewed the different factors that contribute to water loss in meat and meat products, encompassing aspects such as animal species and cuts, pH levels, processing methodologies, storage and packing conditions, and salt concentration. This study reviewed the application of water retention techniques in the context of meat processing and its resultant products. The primary objective of this study is to offer theoretical justification for the reduction of juice loss, preservation of essential water content, enhancement of texture, and improvement of meat quality throughout the stages of processing and storage.
An exploration of alternative proteins as a potential sustainable solution to meeting the nutritional needs of the ever‐increasing global population
Authors: Munialo Claire D. 
Published: March 2024

SummaryProteins of animal origin have been used in various food formulations as they have been shown to possess excellent techno‐functional properties such as gel formation, emulsification, foam ability and stability, among others. However, the production of proteins from animal sources does come at an environmental cost due to the greenhouse effect that is attributable to the rearing of animals. To mitigate against the environmental impact of the production of protein from animal origin, research has focused on alternative proteins such as those of plant, insect or mycoprotein origin. However, there are still several issues as well as mapping of alternative proteins in terms of their nutritional profile, sensorial attributes that include taste and texture as well and the challenges that exist in mimicking proteins of animal origin that need to be addressed which would broaden the window of application of alternative proteins. Therefore, this review explores some of the alternative protein sources that have been characterised in terms of their techno‐functional characteristics and underpins the challenges such as allergenicity that exist in the use of alternative. Furthermore, this work aims to evaluate consumer perception and acceptance of alternative proteins which is pivotal in their success in food production and process as well as ensuring the safety of these proteins. As such, this work will contribute towards the existing knowledge on the possible applications of these proteins as sustainable, cheaper solutions.