bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring adolescents’ experiences of talking about race, ethnicity and culture during dialectical behaviour therapy (DBT): a qualitative study using thematic analysis
Authors: Lei Jiedi , Watkins-Muleba Bec , Sobogun Ireoluwa , Dixey Rebecca , Bagnall Holly , Camp Jake 
Published: March 2024

Abstract
Although anti-racist adaptations to dialectical behaviour therapy (DBT) are emerging, little qualitative research exists exploring adolescents’ perspectives on therapists’ approach, cultural competency and humility regarding ethnicity, race and culture (ERC) within DBT. This study explored diverse adolescents’ experiences of talking about ERC during all aspects of DBT treatment. Ten adolescents from diverse ERC backgrounds who attended DBT at a National and Specialist Child and Adolescent Mental Health Service (UK) completed semi-structured individual interviews that were transcribed verbatim and analysed using reflexive thematic analysis, adopting a critical realist approach. Five over-arching themes were developed from the data. Theme 1 captures the power for explicit ERC-related conversations to facilitate change, as they are frequently overlooked in therapy. Theme 2 discusses factors that facilitate or inhibit ERC-related discussions. Theme 3 captures the difficult ‘double bind’ that adolescents find themselves in: not wanting to be a spokesperson for ERC issues whilst hoping for their therapist to facilitate/model ERC-related discussions. Theme 4 explores how adolescents navigated their identity in relation to ERC, their wider systemic context, and experiences of ERC-related trauma. Theme 5 explored therapeutic alliance, and how therapists might encourage DBT skills use with greater ERC sensitivity, emphasising validation. Using a bottom-up approach, we show a clear mandate from diverse adolescents for (White) clinicians to proactively create the space and safety required for ERC-related discussions. We emphasise the importance of anti-racist praxis including cultural humility, multi-cultural competencies, and validation of ERC-related difficult experiences within a wider systemic context.

Key learning aims

(1)
A recent publication by Pierson et al. (2022) has raised the importance for White DBT therapists to adopt an anti-racist position and actively reflect on how a lack of anti-racist stance can form therapist treatment-interfering behaviours.

(2)
The current study explores the views of adolescents from diverse ethnic, racial and cultural (ERC) backgrounds on how ERC issues are being brought into DBT.

(3)
Adopting a bottom-up approach, we identify key themes from adolescents’ perspectives on the barriers and facilitators to talking about ERC in the therapy room, why such discussions are important in supporting adolescents to navigate their own identity in therapy, and recommendations for clinicians to consider on ways of increasing and enhancing such conversations in the clinical setting.
High-performance terahertz modulators induced by substrate field in Te-based all-2D heterojunctions
Authors: Zhang Pujing , Liang Qihang , Zhou Qingli , Chen Jinyu , Li Menglei , Deng Yuwang , Liang Wanlin , Zhang Liangliang , Zhang Qinghua , Gu Lin , Ge Chen , Jin Kui-juan , Zhang Cunlin , Yang Guozhen 
Published: March 2024

AbstractHigh-performance active terahertz modulators as the indispensable core components are of great importance for the next generation communication technology. However, they currently suffer from the tradeoff between modulation depth and speed. Here, we introduce two-dimensional (2D) tellurium (Te) nanofilms with the unique structure as a new class of optically controlled terahertz modulators and demonstrate their integrated heterojunctions can successfully improve the device performances to the optimal and applicable levels among the existing all-2D broadband modulators. Further photoresponse measurements confirm the significant impact of the stacking order. We first clarify the direction of the substrate-induced electric field through first-principles calculations and uncover the unusual interaction mechanism in the photoexcited carrier dynamics associated with the charge transfer and interlayer exciton recombination. This advances the fundamental and applicative research of Te nanomaterials in high-performance terahertz optoelectronics.
Global, regional, and national burden of type 1 diabetes in adolescents and young adults
Authors: Gong Boshen , Yang Wanyu , Xing Yumin , Lai Yaxin , Shan Zhongyan 
Published: March 2024

Abstract
Background
Type 1 diabetes (T1D) incidence in adolescents varies widely, but has increased globally in recent years. This study reports T1D burden among adolescents and young adults aged 10–24-year-old age group at global, regional, and national levels.

Methods
Based on the Global Burden of Disease Study 2019, we described the burden of T1D in the 10–24-year-old age group. We further analyzed these trends by age, sex, and the Social Development Index. Joinpoint regression analysis was used to assess temporal trends.

Results
T1D incidence among adolescents and young adults increased from 7·78 per 100,000 population (95% UI, 5·27–10·60) in 1990 to 11·07 per 100,000 population (95% UI, 7·42–15·34) in 2019. T1D mortality increased from 5701·19 (95% UI, 4642·70–6444·08) in 1990 to 6,123·04 (95% UI, 5321·82–6887·08) in 2019, representing a 7·40% increase in mortality. The European region had the highest T1D incidence in 2019. Middle-SDI countries exhibited the largest increase in T1D incidence between 1990 and 2019.

Conclusion
T1D is a growing health concern globally, and T1D burden more heavily affects countries with low SDI. Specific measures and effective collaboration among countries with different SDIs are required to improve diabetes care in adolescents.

Impact

We assessed trends in T1D incidence and burden among youth in the 10–24-year-old age group by evaluating data from the Global Burden of Disease Study 2019.

Our results demonstrated that global T1D incidence in this age group increased over the past 30 years, with the European region having the highest T1D incidence.

Specific measures and effective collaboration among countries with different SDIs are required to improve diabetes care in adolescents.
Lin28 affects the proliferation and osteogenic differentiation of human dental pulp stem cells by directly inhibiting let-7b maturation
Authors: Yan Liu , Sun Jing , Wang Yushan , Liu Xinxin , Hu Jiayi , Sun Mengxin , Suo Xi , Duan Rongquan , Yuan Changyong 
Published: March 2024

Abstract
Objective
Activation of Lin28 gene under certain conditions promotes tissue damage repair. However, it remains unknown whether conditional expression of Lin28 facilitates the recovery of damaged pulp tissue. In the study, we focus on exploring the effects and possible regulatory mechanisms of Lin28 on the proliferation and differentiation of human dental pulp stem cells (hDPSCs).

Materials and methods
We adopted techniques such as the ethynyl-2ʹ-deoxyuridine (EdU) incorporation assay, RNA-protein immunoprecipitation (RIP) analysis, and luciferase assays to study the regulation of hDPSCs by Lin28. Furthermore, gain-of-function and loss-of-function analyses were also used in explored factors regulating hDPSCs activation.

Results
The results show that Lin28 inhibited osteogenic differentiation by directly targets pre-let-7b. Through bioinformatics sequencing and dual luciferase experiments we learned that let-7b directly targets the IGF2BP2 3’UTR. Silencing of IGF2BP2 showed a similar biological effect as overexpression of let-7b. Overexpression of IGF2BP2 counteracted the differentiation-promoting effects produced by let-7b overexpression.

Discussion/conclusions
In conclusion, the RNA-binding protein Lin28 regulates osteogenic differentiation of hDPSCs by inhibiting let-7 miRNA maturation. And mature let-7b directly regulated the expression of IGF2BP2 by targeting the 3’UTR region of IGF2BP2 mRNA thus further inhibiting the differentiation of hDPSCs.
Brain regulates weight bearing bone through PGE2 skeletal interoception: implication of ankle osteoarthritis and pain
Authors: Gao Feng , Hu Qimiao , Chen Wenwei , Li Jilong , Qi Cheng , Yan Yiwen , Qian Cheng , Wan Mei , Ficke James , Zheng Junying , Cao Xu 
Published: March 2024

AbstractBone is a mechanosensitive tissue and undergoes constant remodeling to adapt to the mechanical loading environment. However, it is unclear whether the signals of bone cells in response to mechanical stress are processed and interpreted in the brain. In this study, we found that the hypothalamus of the brain regulates bone remodeling and structure by perceiving bone prostaglandin E2 (PGE2) concentration in response to mechanical loading. Bone PGE2 levels are in proportion to their weight bearing. When weight bearing changes in the tail-suspension mice, the PGE2 concentrations in bones change in line with their weight bearing changes. Deletion of cyclooxygenase-2 (COX2) in the osteoblast lineage cells or knockout of receptor 4 (EP4) in sensory nerve blunts bone formation in response to mechanical loading. Moreover, knockout of TrkA in sensory nerve also significantly reduces mechanical load-induced bone formation. Moreover, mechanical loading induces cAMP-response element binding protein (CREB) phosphorylation in the hypothalamic arcuate nucleus (ARC) to inhibit sympathetic tyrosine hydroxylase (TH) expression in the paraventricular nucleus (PVN) for osteogenesis. Finally, we show that elevated PGE2 is associated with ankle osteoarthritis (AOA) and pain. Together, our data demonstrate that in response to mechanical loading, skeletal interoception occurs in the form of hypothalamic processing of PGE2-driven peripheral signaling to maintain physiologic bone homeostasis, while chronically elevated PGE2 can be sensed as pain during AOA and implication of potential treatment.
Hybrid-order topological superconductivity in a topological metal 1T’-MoTe2
Authors: Huang Sheng-Jie , Park Kyungwha , Hsu Yi-Ting 
Published: March 2024

AbstractOne key challenge in the field of topological superconductivity (Tsc) has been the rareness of material realization. This is true not only for the first-order Tsc featuring Majorana surface modes, but also for the higher-order Tsc, which host Majorana hinge and corner modes. Here, we propose a four-step strategy that mathematically derives comprehensive guiding principles for the search and design for materials of general higher-order Tsc phases. Specifically, such recipes consist of conditions on the normal state and pairing symmetry that can lead to a given higher-order Tsc state. We demonstrate this strategy by obtaining recipes for achieving three-dimensional higher-order Tsc phases protected by the inversion symmetry. Following our recipe, we predict that the observed superconductivity in centrosymmetric MoTe2 is a hyrbid-order Tsc candidate, which features both surface and corner modes. Our proposed strategy enables systematic materials search and design for higher-order Tsc, which can mobilize the experimental efforts and accelerate the material discovery for higher-order Tsc phases.
Population coding of strategic variables during foraging in freely moving macaques
Authors: Shahidi Neda , Franch Melissa , Parajuli Arun , Schrater Paul , Wright Anthony , Pitkow Xaq , Dragoi Valentin 
Published: March 2024

AbstractUntil now, it has been difficult to examine the neural bases of foraging in naturalistic environments because previous approaches have relied on restrained animals performing trial-based foraging tasks. Here we allowed unrestrained monkeys to freely interact with concurrent reward options while we wirelessly recorded population activity in the dorsolateral prefrontal cortex. The animals decided when and where to forage based on whether their prediction of reward was fulfilled or violated. This prediction was not solely based on a history of reward delivery, but also on the understanding that waiting longer improves the chance of reward. The task variables were continuously represented in a subspace of the high-dimensional population activity, and this compressed representation predicted the animal’s subsequent choices better than the true task variables and as well as the raw neural activity. Our results indicate that monkeys’ foraging strategies are based on a cortical model of reward dynamics as animals freely explore their environment.
Quantification of myocardial scar of different etiology using dark- and bright-blood late gadolinium enhancement cardiovascular magnetic resonance
Authors: Jada Lamis , Holtackers Robert J. , Martens Bibi , Nies Hedwig M. J. M. , Van De Heyning Caroline M. , Botnar Rene M. , Wildberger Joachim E. , Ismail Tevfik F. , Razavi Reza , Chiribiri Amedeo 
Published: March 2024

AbstractDark-blood late gadolinium enhancement (LGE) has been shown to improve the visualization and quantification of areas of ischemic scar compared to standard bright-blood LGE. Recently, the performance of various semi-automated quantification methods has been evaluated for the assessment of infarct size using both dark-blood LGE and conventional bright-blood LGE with histopathology as a reference standard. However, the impact of this sequence on different quantification strategies in vivo remains uncertain. In this study, various semi-automated scar quantification methods were evaluated for a range of different ischemic and non-ischemic pathologies encountered in clinical practice. A total of 62 patients referred for clinical cardiovascular magnetic resonance (CMR) were retrospectively included. All patients had a confirmed diagnosis of either ischemic heart disease (IHD; n = 21), dilated/non-ischemic cardiomyopathy (NICM; n = 21), or hypertrophic cardiomyopathy (HCM; n = 20) and underwent CMR on a 1.5 T scanner including both bright- and dark-blood LGE using a standard PSIR sequence. Both methods used identical sequence settings as per clinical protocol, apart from the inversion time parameter, which was set differently. All short-axis LGE images with scar were manually segmented for epicardial and endocardial borders. The extent of LGE was then measured visually by manual signal thresholding, and semi-automatically by signal thresholding using the standard deviation (SD) and the full width at half maximum (FWHM) methods. For all quantification methods in the IHD group, except the 6 SD method, dark-blood LGE detected significantly more enhancement compared to bright-blood LGE (p < 0.05 for all methods). For both bright-blood and dark-blood LGE, the 6 SD method correlated best with manual thresholding (16.9% vs. 17.1% and 20.1% vs. 20.4%, respectively). For the NICM group, no significant differences between LGE methods were found. For bright-blood LGE, the 5 SD method agreed best with manual thresholding (9.3% vs. 11.0%), while for dark-blood LGE the 4 SD method agreed best (12.6% vs. 11.5%). Similarly, for the HCM group no significant differences between LGE methods were found. For bright-blood LGE, the 6 SD method agreed best with manual thresholding (10.9% vs. 12.2%), while for dark-blood LGE the 5 SD method agreed best (13.2% vs. 11.5%). Semi-automated LGE quantification using dark-blood LGE images is feasible in both patients with ischemic and non-ischemic scar patterns. Given the advantage in detecting scar in patients with ischemic heart disease and no disadvantage in patients with non-ischemic scar, dark-blood LGE can be readily and widely adopted into clinical practice without compromising on quantification.
Gut dysbiosis is linked to metabolic syndrome in obese Egyptian women: potential treatment by probiotics and high fiber diets regimen
Authors: Hassan Nayera E. , El-Masry Sahar A. , El Shebini Salwa M. , Ahmed Nihad H. , Mohamed T Fouad , Mostafa Mohammed I. , Afify Mahmoud A. S. , Kamal Ayat N. , Badie Mai M. , Hashish Adel , Alian Khadija 
Published: March 2024

AbstractMetabolic syndrome (MetS) is defined as a cluster of glucose intolerance, hypertension, dyslipidemia, and central obesity with insulin resistance. The role of gut microbiota in metabolic disorders is increasingly considered. To investigate the effects of probiotic supplements and hypocaloric high fiber regimen on MetS in obese Egyptian women. A longitudinal follow-up intervention study included 58 obese Egyptian women, with a mean age of 41.62 ± 10.70 years. They were grouped according to the criteria of MetS into 2 groups; 23 obese women with MetS and 35 ones without MetS. They followed a hypocaloric high fiber regimen weight loss program, light physical exercise, and received a probiotic supplement daily for 3 months. For each participating woman, blood pressure, anthropometric measurements, basal metabolic rate (BMR), dietary recalls, laboratory investigations, and microbiota analysis were acquired before and after 3 months of follow-up. After intervention by the probiotic and hypocaloric high fiber regimen and light exercise, reduction ranged from numerical to significant difference in the anthropometric parameters, blood pressure, and BMR was reported. All the biochemical parameters characterized by MetS decreased significantly at p ≤ 0.05–0.01. Before the intervention, results revealed abundant of Bacteroidetes bacteria over Firmicutes with a low Firmicutes/Bacteroidetes ratio. After the intervention, Log Lactobacillus, Log Bifidobacteria, and Log Bacteroidetes increased significantly in both groups, while Log Firmicutes and the Firmicutes/Bacteroidetes Ratio revealed a significant decrease. In conclusion, this study’s results highlight a positive trend of probiotics supplementation with hypocaloric high-fiber diets in amelioration of the criteria of the Mets in obese Egyptian women.
Schober test is not a valid assessment tool for lumbar mobility
Authors: Taheri Nima , Becker Luis , Reitmaier Sandra , Muellner Maximilian , Schömig Friederike , Pumberger Matthias , Schmidt Hendrik 
Published: March 2024

AbstractThe Schober test is considered reliable in evaluating lumbar mobility and its impairment. Especially in patients with chronic low back pain (cLBP) identification of functional restriction is important. We aimed to investigate whether the 5 cm Schober cut-off provides a valid distinction between unrestricted and restricted mobility in participants with and without cLBP (18–65 years). cLBP is defined as LBP persisting for ≥ 12 weeks. We analyzed agreement between the Schober test with two measurement devices (Epionics SPINE®; Idiag M360®) and the influence of lumbar lordosis (LL) on their agreement. Also, the sensitivity and specificity of the Schober test was evaluated. For 187 participants (49.6%) Epionics SPINE® RoF and Schober test matched (either ≥ 5 cm; > 40.8° RoF or ≤ 5 cm; < 40.8° RoF), for 190 participants (50.4%) the two measurements did not. Idiag M360® RoF of 190 participants (50.4%) showed corresponding results (either ≥ 5 cm; > 46.0° RoF or ≤ 5 cm; < 46.0° RoF). Non-agreement was seen in 187 participants (49.6%). LL differed significantly in the Epionics SPINE® cohort (p < 0.001). Regarding the Epionics SPINE® cohort, Schober test showed a sensitivity of 79.6% with a specificity of 36.1%. For the Idiag M360® cohort, Schober test showed a sensitivity of 68.2% and a specificity of 46.6%. Our results do not establish a consistent matching between Schober test and the device measurements. Therefore, Schober test may not be valid to predict impairment of lumbar mobility. We recommend Schober test as an add-on in monitoring of an individual relative to its case.
A rational study of transduction mechanisms of different materials for all solid contact-ISEs
Authors: Hashem Heba M. , Abdallah A. B. 
Published: March 2024

AbstractThe new era of solid contact ion selective electrodes (SC-ISEs) miniaturized design has received an extensive amount of concern. Because it eliminated the requirement for ongoing internal solution composition optimization and created a two-phase system with stronger detection limitations. Herein, the determination of venlafaxine HCl is based on a comparison study between different ion- to electron transduction materials (such as; multiwalled carbon nanotubes (MWCNTs), polyaniline (PANi), and ferrocene) and illustrating their mechanisms in their applied sensors. Their different electrochemical features (such as bulk resistance (Rb**), double-layer capacitance (Cdl), geometric capacitance (Cg), and specific capacitance (Cp)) were evaluated and discussed by using the Electrochemical Impedance Spectroscopy (EIS), Chronopotentiometry (CP), and Cyclic Voltammetry (CV) experiments. The results indicated that each transducer's influence on the proposed sensor's electrochemical characteristics is determined by their unique chemical and physical properties. The electrochemical features vary for different solid contact materials used in transduction mechanisms. The results confirm that the MWCNT sensor revealed the best electrochemical behavior with the potentiometric response of a near-Nernestian slope of 56.1 ± 0.8 mV/decade with detection limits of 3.8 × 10−6 mol/L (r2 = 0.999) and a low potential drift (∆E/∆t) of 34.6 µV/s. Also, the selectivity study was performed in the presence of different interfering species either in single or complex matrices. This demonstrates excellent selectivity, stability, conductivity, and reliability as a VEN-TPB ion pair sensor for accurately measuring VEN in its various formulations. The proposed method was compared to HPLC reported technique and confirmed no significant difference between them. So, the proposed sensors fulfill their solutions' demand features for VEN appraisal.
Analyzing the spatial motion of a rigid body subjected to constant body-fixed torques and gyrostatic moment
Authors: Amer T. S. , El-Kafly H. F. , Elneklawy A. H. , Galal A. A. 
Published: March 2024

AbstractThis paper aims to explore the rotatory spatial motion of an asymmetric rigid body (RB) under constant body-fixed torques and a nonzero first component gyrostatic moment vector (GM). Euler's equations of motion are used to derive a set of dimensionless equations of motion, which are then proposed for the stability analysis of equilibrium points. Specifically, this study develops 3D phase space trajectories for three distinct scenarios; two of them are applied constant torques that are directed on the minor and major axes, while the third one is the action of applied constant torque on the body’s middle axis. Novel analytical and simulation results for both scenarios of constant torque applied along the minor and middle axes are provided in the context of separatrix surfaces, equilibrium manifolds, periodic or non-periodic solutions, and periodic solutions’ extreme. Concerning the scenario of a directed torque on the major axis, a numerical solution for the problem is presented in addition to a simulation of the graphed results for the angular velocities' trajectories in various regions. Moreover, the influence of GM is examined for each case and a full modeling for the body's stability has been present. The exceptional impact of these results is evident in the development and assessment of systems involving asymmetric RBs, such as satellites and spacecraft. It may serve as a motivating factor to explore different angles within the GM in similar cases, thereby influencing various industries, including engineering and astrophysics applications.