bluuebunny/crossref_metadata_2025_split huggingface dataset:
RPL35A drives ovarian cancer progression by promoting the binding of YY1 to CTCF promoter
Authors: Wu Huijuan , Xia Liangbin , Sun Lu , Li Dan , Liu Xiangyu , Song Hualin , Sheng Jindong , Wang Ke , Feng Qinmei 
Published: March 2024

AbstractOvarian cancer is one of the most common gynaecological malignancies with poor prognosis and lack of effective treatment. The improvement of the situation of ovarian cancer urgently requires the exploration of its molecular mechanism to develop more effective molecular targeted drugs. In this study, the role of human ribosomal protein l35a (RPL35A) in ovarian cancer was explored in vitro and in vivo. Our data identified that RPL35A expression was abnormally elevated in ovarian cancer. Clinically, high expression of RPL35A predicted short survival and poor TNM staging in patients with ovarian cancer. Functionally, RPL35A knock down inhibited ovarian cancer cell proliferation and migration, enhanced apoptosis, while overexpression had the opposite effect. Mechanically, RPL35A promoted the direct binding of transcription factor YY1 to CTCF in ovarian cancer cells. Consistently, RPL35A regulated ovarian cancer progression depending on CTCF in vitro and in vivo. Furthermore, RPL35A affected the proliferation and apoptosis of ovarian cancer cells through PPAR signalling pathway. In conclusion, RPL35A drove ovarian cancer progression by promoting the binding of YY1 and CTCF promoter, and inhibiting this process may be an effective strategy for targeted therapy of this disease.
Cities as Actors in the EU Policy Towards China
Authors: Kamiński Tomasz , Ciesielska‐Klikowska Joanna , Gzik Michał 
Published: March 2024

AbstractCity diplomacy between European Union (EU) and Chinese cities has become an increasingly significant layer of bilateral relations. The collaboration between cities is extensive and covers a wide range of thematic areas, with around half of European cities having partnerships with Chinese counterparts, according to a survey of 745 cities. However, despite the commonality of these partnerships, our research has highlighted a disconnect between subnational relations and the upper levels of European policy. Despite some previous initiatives, local actors have not been effectively engaged in EU policy‐making. The European Parliament has called for greater co‐ordination with substate actors, but this call has gone unanswered. This article unpacks the city level of EU relations with China, showing its scope, patterns of co‐operation and potential impact. The authors present theoretical and empirical arguments to support the notion that city diplomacy could have a much more significant impact on EU policy towards China.
Gender diversity is correlated with dimensional neurodivergent traits but not categorical neurodevelopmental diagnoses in children
Authors: Mo Kelly , Anagnostou Evdokia , Lerch Jason P. , Taylor Margot J. , VanderLaan Doug P. , Szatmari Peter , Crosbie Jennifer , Nicolson Robert , Georgiadis Stelios , Kelley Elizabeth , Ayub Muhammad , Brian Jessica , Lai Meng‐Chuan , Palmert Mark R. 
Published: March 2024

BackgroundGender clinic and single‐item questionnaire‐based data report increased co‐occurrence of gender diversity and neurodevelopmental conditions. The nuances of these associations are under‐studied. We used a transdiagnostic approach, combining categorical and dimensional characterization of neurodiversity, to further the understanding of its associations with gender diversity in identity and expression in children.MethodsData from 291 children (Autism N = 104, ADHD N = 104, Autism + ADHD N = 17, neurotypical N = 66) aged 4–12 years enrolled in the Province of Ontario Neurodevelopmental Network were analyzed. Gender diversity was measured multi‐dimensionally using a well‐validated parent‐report instrument, the Gender Identity Questionnaire for Children (GIQC). We used gamma regression models to determine the significant correlates of gender diversity among age, puberty, sex‐assigned‐at‐birth, categorical neurodevelopmental diagnoses, and dimensional neurodivergent traits (using the Social Communication Questionnaire and the Strengths and Weaknesses of ADHD Symptoms and Normal Behavior Rating Scales). Internalizing and externalizing problems were included as covariates.ResultsNeither a categorical diagnosis of autism nor ADHD significantly correlated with current GIQC‐derived scores. Instead, higher early‐childhood dimensional autistic social‐communication traits correlated with higher current overall gender incongruence (as defined by GIQC‐14 score). This correlation was potentially moderated by sex‐assigned‐at‐birth: greater early‐childhood autistic social‐communication traits were associated with higher current overall gender incongruence in assigned‐males‐at‐birth, but not assigned‐females‐at‐birth. For fine‐grained gender diversity domains, greater autistic restricted‐repetitive behavior traits were associated with greater diversity in gender identity across sexes‐assigned‐at‐birth; greater autistic social‐communication traits were associated with lower stereotypical male expression across sexes‐assigned‐at‐birth.ConclusionsDimensional autistic traits, rather than ADHD traits or categorical neurodevelopmental diagnoses, were associated with gender diversity domains across neurodivergent and neurotypical children. The association between early‐childhood autistic social‐communication traits and overall current gender diversity was most evident in assigned‐males‐at‐birth. Nuanced interrelationships between neurodivergence and gender diversity should be better understood to clarify developmental links and to offer tailored support for neurodivergent and gender‐diverse populations.
Malnutrition in emergency general surgery: a survey of National Emergency Laparotomy Audit Leads
Authors: Ashmore Daniel L. , Wilson Timothy , Halliday Vanessa , Lee Matthew 
Published: March 2024

AbstractBackgroundPatients who are malnourished and have emergency general surgery, such as a laparotomy, have worse outcomes than those who are not malnourished. It is paramount to identify these patients and minimise this risk. This study aimed to describe current practices in identifying malnutrition in patients undergoing a laparotomy, specifically focusing on screening, assessment, nutrition pathways and barriers encountered by clinicians.MethodsFollowing piloting and validity assessment, anaesthetic and surgical National Emergency Laparotomy Audit (NELA) Leads at hospitals across England and Wales were emailed an invitation to a survey. Responses were gathered using Qualtrics. Descriptive analysis and correlation with laparotomy volume and professional role were performed in SPSSv26. University of Sheffield ethical approval was obtained (UREC 046205). The results from the survey are reported according to the CHERRIES guidelines.ResultsThe survey was completed by 166/289 NELA Leads from 117/167 hospitals (57.4% and 70.1% response rates, respectively). Participants reported low rates of nutritional screening (42/166; 25.3%) and assessment (26/166; 15.7%) for malnutrition preoperatively. More than one third of respondents (40.1%) had no awareness of local screening tools; indeed, the Malnutrition Universal Screening Tool (MUST) was used by approximately half of respondents (56.6%). Contrary to guidelines, NELA Leads report albumin levels continue to be used to determine malnutrition risk (73.5%; 122/166). Postoperative nutrition pathways were common (71.7%; 119/166). Reported barriers to nutritional screening and assessment included a lack of time, training and education, organisational support and ownership. Participants indicated nutrition risk is inadequately identified and is an important missing data item from NELA. There was no significant correlation with hospital laparotomy volume in relation to screening or assessment for malnutrition, the use of nutritional support pathways or organisational barriers. There was interprofessional agreement across a number of domains, although some differences did exist.ConclusionsWide variation exists in the current practice of identifying malnutrition risk in NELA patients. Barriers include a lack of time, knowledge and ownership. Nutrition pathways that encompass the preoperative phase and incorporation of nutrition data in NELA may support improvements in care.
Due Diligence
Authors: DALEY BRENDAN , GEELEN THOMAS , GREEN BRETT 
Published: March 2024

ABSTRACTWe propose a model of due diligence and analyze its effect on prices, payoffs, and deal completion. In our model, if the seller accepts an offer, the winning bidder (or “acquirer”) can gather information and chooses when to complete the transaction. In equilibrium, the acquirer engages in “too much” due diligence. Our quantitative results suggest that the magnitude of the distortion is economically significant. Nevertheless, allowing for due diligence can improve both total surplus and the seller's payoff compared to a setting without due diligence. We use our framework to explore the timing of due diligence, bidder heterogeneity, and breakup fees.
Profiling and functional analysis of circular RNAs in yaks intramuscular fat
Authors: Su Quyangangmao , Raza Sayed Haidar Abbas , Gao Zhanhong , Zhang Fengshuo , Wu ZhenLing , Ji QiuRong , He TingLi , Aloufi Bandar Hamad , El‐Mansi Ahmed A. , Eldesoqui Mamdouh , Sabir Deema Kamal , Gui Linsheng 
Published: March 2024

AbstractCircular RNAs (circRNAs) are a new class of endogenous RNA regulating gene expression. However, the regulatory mechanisms of lipid metabolism in yaks involved in circRNAs remain poorly understood. The IMF plays a crucial role in the quality of yak meat, to greatly improve the meat quality. In this study, the fatty acid profiles of yak IMF were determined and circRNAs were sequenced. The results showed that the total of polyunsaturated fatty acid (PUFA) content of adult yak muscle was significantly higher than that in yak calves (p < 0.05). A total of 29,021 circRNAs were identified in IMF tissue, notably, 99 differentially expressed (DE) circRNAs were identified, to be associated with fat deposition, the most significant of which were circ_12686, circ_6918, circ_3582, ci_106 and ci_123 (A circRNA composed of exons is labelled ‘circRNA’ and a circRNA composed of introns is labelled ‘ciRNA’). KEGG pathway enrichment analysis showed that the differential circRNAs were enriched in four pathways associated with fat deposition (e.g., the peroxisome proliferator‐activated receptor signalling, fatty acid degradation, sphingolipid metabolism and sphingolipid signalling pathways). We also constructed co‐expression networks of DE circRNA‐miRNA using high‐throughput sequencing in IMF deposition, from which revealed that ci_106 target binding of bta‐miR‐130b, bta‐miR‐148a, bta‐miR‐15a, bta‐miR‐34a, bta‐miR‐130a, bta‐miR‐17‐5p and ci_123 target binding of bta‐miR‐150 were involved in adipogenesis. The study revealed the role of the circRNAs in the IMF deposition in yak and its influence on meat quality the findings demonstrated the circRNA differences in the development of IMF with the increase of age, thus providing a theoretical basis for further research on the molecular mechanism of IMF deposition in yaks.
Healthcare for people with intellectual and developmental disabilities in Italy
Authors: Bacherini Alice , Pierluigi Irene , Balboni Giulia 
Published: March 2024

AbstractThe Italian healthcare system is public and freely available to the population. With a few exceptions, there are no distinctions between the healthcare services and practices (e.g., primary care) designed for the general population and those for individuals with intellectual and developmental disabilities (IDD). Prevalence data on adults with IDD are lacking and most disability policies and resources are designed for people with disabilities broadly defined, without specification based on disability type or severity level. Recent legislation provides specific supports for individuals with severe disabilities or autism spectrum disorder. This paper describes the legislation and health policies developed for people with disabilities, the organization of the Italian healthcare system, and the organization of disability support services and healthcare services. Strengths (e.g., availability of many financial resources, adoption of biopsychosocial approach to disability, presence of innovative projects to address the healthcare needs of people with IDD) and weaknesses (e.g., lack of distinction among disability types, territorial differences, lack of disability training of healthcare providers) of the current healthcare practices are reported and discussed.
Ireland's approach to health and social care policy and practice for people with intellectual and developmental disabilities
Authors: Fennelly Aoife , Tully Michael , Henderson Karen , Rojack Éilis , Jones Tracey , Jackman Catherine 
Published: March 2024

AbstractIrish health and social care policy has undergone a significant evolution in recent years to address inequalities, improve standards and update models of care to incorporate a rights‐based approach. The following account describes the Irish health and social care system, as delivered in the Republic of Ireland, and details how it operates for those with intellectual and developmental disabilities. The paper is informed by government policy, legislation, reviews, national plans, parliamentary reports, and population data. Clear progress has been made in shifting from a service‐led to a rights‐based, service‐user led model of care; however, resourcing this fundamental transition in approach to service provision poses challenges for the Irish State.
Kidney adolescent and young adult clinic: A transition model in Africa
Authors: Barday Zibya , Davidson Bianca , Harden Paul , Mukuddem‐Sablay Zakira , Wearne Nicola , Jones Erika S. W. , Cross Daley , McCulloch Mignon 
Published: March 2024

AbstractAdolescents and Young Adults (AYAs) with chronic kidney disease (CKD) have challenges unique to this developmental period, with increased rates of high‐risk behavior and non‐adherence to therapy which may impact the progression of kidney disease and their requirement for kidney replacement therapy (KRT). Successful transition of AYA patients are particularly important in low‐ and middle‐income countries (LMICs) where KRT is limited, rationed or not available. Kidney AYA transition clinics have the potential to improve clinical outcomes but there is a paucity of data on the clinical translational impact of these clinics in Africa. This review is a reflection of the 20‐year growth and development of the first South African kidney AYA transition clinic. We describe a model of care for patients with CKD, irrespective of etiology, aged 10–25 years, transitioning from pediatric to adult nephrology services. This unique service was established in 2002 and re‐designed in 2015. This multidisciplinary integrated transition model has improved patient outcomes, created peer support groups and formed a training platform for future pediatric and adult nephrologists. In addition, an Adolescent Centre of Excellence has been created to compliment the kidney AYA transition model of care. The development of this transition pathway challenges and solutions are explored in this article. This is the first kidney AYA transition clinic in Africa. The scope of this service has expanded over the last two decades. With limited resources in LMICs, such as KRT, the structured transition of AYAs with kidney disease is not only possible but essential. It is imperative to preserve residual kidney function, maximize the kidney allograft lifespan and improve adherence, to enable young individuals an opportunity to lead productive lives.
Identification and pathogenicity of Colletotrichum species associated with twig dieback of citrus in Western Australia
Authors: Wang Weixia , Taylor Andrew S. , Tongson Eden , Edwards Jacqueline , Vaghefi Niloofar , Ades Peter K. , Crous Pedro W. , Taylor Paul W. J. 
Published: March 2024

AbstractUp to 32 Colletotrichum species have been reported to be associated with pre‐ or postharvest diseases of citrus globally, while in Australia, six species have been reported to cause citrus leaf and fruit disease. Twig or shoot dieback has recently been observed as an emerging disease in citrus orchards in Western Australia. Colletotrichum species were isolated from diseased twigs showing dieback (withertip) or lesions, with or without gummosis, collected from 12 varieties of orange, mandarin and lemon. Colletotrichum gloeosporioides sensu stricto, Colletotrichum karstii and Colletotrichum novae‐zelandiae were identified using a polyphasic approach that included multigene phylogenetic analysis using sequences of internal transcribed spacer and intervening 5.8S nrDNA (ITS), glyceraldehyde‐3‐phosphate dehydrogenase (gapdh), β‐tubulin (tub2), actin (act) and histone (his3) for isolates in the boninense species complex, and Apn2–Mat1–2 intergenic spacer and partial mating type (Mat1–2) (ApMat) and glutamine synthetase (gs) for isolates in the gloeosporioides species complex, as well as morphological characteristics. C. gloeosporioides was the most prevalent species associated with twig dieback in Western Australia, while C. novae‐zelandiae was reported for the first time in Australia. Pathogenicity tests on shoot twigs from lemon and orange trees confirmed C. gloeosporioides, C. karstii and C. novae‐zelandiae as the cause of twig dieback, with C. gloeosporioides being the most aggressive species. Knowledge of the species causing twig dieback and their lifestyle will assist the development of integrated control methods.
Small codes
Authors: Balla Igor 
Published: March 2024

AbstractDetermining the maximum number of unit vectors in with no pairwise inner product exceeding is a fundamental problem in geometry and coding theory. In 1955, Rankin resolved this problem for all , and in this paper, we show that the maximum is for all , answering a question of Bukh and Cox. Moreover, the exponent is best possible. As a consequence, we obtain an upper bound on the size of a ‐ary code with block length and distance , which is tight up to the multiplicative factor for any prime power and infinitely many . When , this resolves a conjecture of Tietäväinen from 1980 in a strong form and the exponent is best possible. Finally, using a recently discovered connection to ‐ary codes, we obtain analogous results for set‐coloring Ramsey numbers.
Physical Activity Patterns Within Dementia Care Dyads
Authors: Farina Nicolas , McArdle Ríona , Lowry Ruth G. , Banerjee Sube 
Published: March 2024

Previous research has explored the physical activity habits of people with dementia and their family carers separately, with little consideration of how physical habits are associated within dyads. In this observational study, we sought to explore the relationship between people with dementia and their carers’ physical activity, at a group level and at a dyadic level. Twenty-six participant dyads (persons with dementia and their carer spouses) were asked to wear an accelerometer for 30 days continuously. Comparisons were made at a group level and a dyadic level. People with dementia did not participate in significantly more moderate to vigorous physical activity (M = 15.44 min/day; SD = 14.40) compared with carers (M = 17.95 min/day; SD = 17.01). Within dyads, there were moderately strong associations between daily moderate to vigorous physical activity (r = .48–.54), but not with overall activity levels (r = .24). Despite physical activity habits remaining relatively low within people with dementia and carers, respectively, moderate to vigorous physical activity levels appear to be correlated within dyads. Understanding mutual influence on physical activity levels within dyads is an important pathway to promote an active lifestyle.
Physiological adventures in
Candida albicans
: farnesol and ubiquinones
Authors: Nickerson Kenneth W. , Gutzmann Daniel J. , Boone Cory H. T. , Pathirana Ruvini U. , Atkin Audrey L. 
Published: March 2024

SUMMARY

Farnesol was first identified as a quorum-sensing molecule, which blocked the yeast to hyphal transition in
Candida albicans
, 22 years ago. However, its interactions with
Candida
biology are surprisingly complex. Exogenous (secreted or supplied) farnesol can also act as a virulence factor during pathogenesis and as a fungicidal agent triggering apoptosis in other competing fungi. Farnesol synthesis is turned off both during anaerobic growth and in opaque cells. Distinctly different cellular responses are observed as exogenous farnesol levels are increased from 0.1 to 100 µM. Reported changes include altered morphology, stress response, pathogenicity, antibiotic sensitivity/resistance, and even cell lysis. Throughout, there has been a dearth of mechanisms associated with these observations, in part due to the absence of accurate measurement of intracellular farnesol levels (
F

i

). This obstacle has recently been overcome, and the above phenomena can now be viewed in terms of changing
F

i

levels and the percentage of farnesol secreted. Critically, two aspects of isoprenoid metabolism present in higher organisms are absent in
C. albicans
and likely in other yeasts. These are pathways for farnesol salvage (converting farnesol to farnesyl pyrophosphate) and farnesylcysteine cleavage, a necessary step in the turnover of farnesylated proteins. Together, these developments suggest a unifying model, whereby high, threshold levels of
F

i

regulate which target proteins are farnesylated or the extent to which they are farnesylated. Thus, we suggest that the diversity of cellular responses to farnesol reflects the diversity of the proteins that are or are not farnesylated.
Luminosity of accretion disks around rotating regular black holes
Authors: Boshkayev Kuantay , Konysbayev Talgar , Kurmanov Yergali , Luongo Orlando , Muccino Marco , Taukenova Aliya , Urazalina Ainur 
Published: March 2024

AbstractWe study thin accretion disks in the gravitational field of a class of rotating regular black holes. Our objective is to determine the key parameters governing these accretion disks: the radius of the innermost stable circular orbit $$(r_{\textrm{ISCO}})$$

(

r
ISCO

)

and the efficiency $$(\eta )$$

(
η
)

of the accretion disk in converting matter into radiation. We employ a simplified model to describe the disk’s radiative flux, and differential and spectral luminosity. Subsequently, we compare our findings with the expectations from accretion disks around Kerr black holes. Notably, our calculations reveal that both the luminosity of the accretion disk and its efficiency are greater when considering the geometry of rotating regular black holes, particularly for fixed and small values of the spin parameter (j), in contrast to the predictions obtained using the Kerr metric for a black hole of the same mass. These results offer intriguing insights into the behavior of astrophysical black holes.