bluuebunny/crossref_metadata_2025_split huggingface dataset:
TRANSCATHETER AORTIC VALVE REPLACEMENT: FROM IDEA TO IMPLEMENTATION
Authors: Ganyukov Vladimir I. , Tarasov Roman S. , Kolesnikov Alexey Yu. , Ganyukov Ivan V. 
Published: April 2024

HighlightsTranscatheter aortic valve replacement is an innovative trend in modern cardiovascular surgery. This minimally invasive image-guided endovascular technology is becoming more and more safe, nowadays it can involve a minimalistic approach in which the aortic valve replacement is performed without incisions, anesthesia and cardiopulmonary bypass - patients are conscious and spontaneously breathing. The article describes a paradigm shift in modern cardiology, in which the concept of treating patients with degenerative aortic valve stenosis has changed over the 20 years of existence of the transcatheter replacement, starting as a method used only in small number of extremely high-risk patients unsuitable for cardiac surgery and now being the most prevalent treatment modality in patients at intermediate and even low surgical risk. The main clinical and technical principles of transcatheter aortic valve replacement, as well as the prospects for the development of this technique, are highlighted. Abstract Transcatheter aortic valve replacement technique was first implemented about 20 years ago, in April 2002. A quarter of a century ago, specialists involved in image-guided surgery would have never believed that they would perform transcatheter interventions on heart valves. Transcatheter interventions are an alternative to open-heart surgery for acquired heart disease. Transcatheter heart valve replacement or repeat transcatheter aortic valve replacement, which do not require incisions, cardiopulmonary bypass, and in some cases general anesthesia, to this day continue to be perceived as revolutionary and breakthrough, saving the lives of many patients. The article presents the main milestones in the development of image-guided endovascular surgery and transcatheter aortic valve replacement technique, the number of which in the United States and several European countries increases by 10–15% annually, reaching hundreds of thousands per year. The etiology and pathophysiology of aortic stenosis, the technique of transcatheter aortic valve replacement and the outcome of this promising minimally invasive procedure are presented.
DEVELOPMENT AND SUBSTANTIATION OF PROMISING MODELS OF MEDICAL CARE FOR DISEASES OF CIRCULATORY SYSTEM IN INDUSTRIAL REGION. 2010–2023 RESULTS
Authors: Artamonova Galina V. , Bazdyrev Evgeny D. , Makarov Sergey A. 
Published: April 2024

HighlightsWe have identified regional peculiarities of traditional and non-traditional cardiovascular risk factors.We have defined and characterized clinical and organizational characteristics of the specialized care, prevention, and treatment of diseases of the circulatory system in the Kemerovo region - Kuzbass.Moreover, we have described the principles of innovative organizational models for improving care for patients with diseases of the circulatory system, focused on the needs of outpatient organizations. AbstractThe review presents the main research findings obtained at the Department of Optimization of Medical Care for Cardiovascular Diseases of the Research Institute for Complex Issues of Cardiovascular Diseases over the past 13 years of work. The uniqueness of the obtained data lies in the fact that we have identified regional peculiarities of cardiovascular risk factors in residents of an industrial region (using the Kemerovo region data). Data on monitoring of health and risk factors served as the basis for the development of innovative organizational models for improving care for patients with diseases of the circulatory system from the stage of primary care to tertiary care using a systematic and integrated approach, and situational analysis. Management decisions within models are based on international quality standards that reaffirm that risk-based management, the role of personnel and the work environment are the integral to the improvement of performance and the achievement of the main goals of medical organization. Using the project approach, we have implemented management tools for internal quality control and safety of patients and personnel.
EFFECTIVENESS OF A BIOLOGICAL PROSTHESIS IN THE TREATMENT OF TRAUMATIC FEMORAL ARTERY INJURIES
Authors: Sukovatykh Boris S. , Aptarov Zainiddin N. , Sukovatykh Mikhail B. , Gordov Maksim Yu. , Grigoryan Arsen Yu. 
Published: April 2024

HighlightsThe prevalence of vascular injuries during military engagements can reach 20%. In the thigh, vascular injuries are the second most frequent type of injury. Vascular replacement using a graft is required in case of a femoral artery injury with length of more than 10 cm. If autologous blood vessels are not available for replacement, specialists resort to using a synthetic prosthesis. Selection of an appropriate prosthesis remains a priority for vascular surgeons. Aim. To evaluate the outcome of vascular replacement using a biological prosthesis derived from bovine internal thoracic arteries for the treatment of femoral artery injuries.Material and methods. The study involved 30 patients with femoral artery injuries. The analysis focused on the indicators of comprehensive examination and treatment of these patients, who were divided into 2 statistically homogeneous groups of 15 people each. In the first group, a biological prosthesis derived from bovine internal thoracic artery was used to replace the artery, and in the second group, a large subcutaneous vein was used. The results of treatment were evaluated by the number of postoperative complications, the durability of grafts and the quality of life of patients.Results. There were no fatal cases. In the first group, 6 (40%) patients suffered postoperative complications, and in the second group – in 5 (33.3%) patients. After 5 years, 12 (80%) grafts remained functioning in the first group, and 13 (86.7%) grafts in the second group. The physical component of the health of patients in the first group was equal to 60.6 ± 3.2, in the second group – 62.5 ± 3.4, and the psychological component of health 58.7 ± 2.8, and 59.5 ± 3.1, respectively. There was no statistical reliability between the indicators of the groups (p > 0.05).Conclusion. Biological prosthesis derived from bovine internal thoracic arteries for the treatment of femoral artery injuries is quite effective.
PHYSICAL AND MECHANICAL PROPERTIES OF CONDUITS DURING THE FORMATION OF THE OUTFLOW TRACT INTO THE PULMONARY ARTERY
Authors: Soynov Ilya A. , Rzaeva Ksenia A. , Gorbatykh Artyom V. , Voitov Alexey V. , Arkhipov Alexey N. , Nichay Natalya R. , Kulyabin Yuri Y. , Manukyan Sergei N. , Bogachev-Prokophiev Alexander V. 
Published: April 2024

HighlightsWe have evaluated the rigidity and distensibility of conduits in the long-term period using transthoracic echocardiography. The assessment of elastic properties will make it possible to predict degenerative changes in the conduit and choose the optimal prosthesis. AbstractAim. To evaluate changes in the rigidity and distensibility of conduits in patients after the formation of an outflow tract into the pulmonary artery in comparison with the control group of “healthy” children.Methods. The prospective non-randomized two-center study included 58 people with right ventricular dysfunction who underwent primary conduit implantation between the ages of 3 and 15 years. To assess the elastic properties of the pulmonary artery, a control group of 25 patients (healthy children who agreed to participate in the study) was introduced. The study was carried out at the Meshalkin National Medical Research Center and the Almazov National Medical Research Centre. All patients were divided into 4 groups: healthy children (n = 25), formation of the outflow tract with a pulmonary homograft (n = 28), and formation of the outflow tract with Contegra conduit (n = 19), formation with a xenopericardial conduit (n = 11).Results. The only differences between the groups were the RV EDV index, RV CVD index, RV FIP, severe pulmonary regurgitation, and tricuspid regurgitation. There is a significant difference between the groups in the long-term period (after 12 and 24 months), both in terms of rigidity and elasticity. The only difference in the long-term period after 12 months was the degree of tricuspid regurgitation, which was significantly lower in the control group. After 24 months, the peak gradient between the right ventricle and the pulmonary artery was different, which was significantly higher in the group of xenopericardial conduits and the degree of pulmonary regurgitation, which was significantly lower in the control group.Conclusion. The conduits show higher stiffness in the long-term period in contrast to the normal pulmonary artery, which may affect the durability of the conduits.
Smart specialization: origin and state of the art
Authors: Gamidullaeva L. A. 
Published: April 2024

Purpose: is to identify state of the art, key aspects and distinctive characteristics of the smart specialization concept based on a study of the current state and the initial prerequisites for its formation, including linkages with other theoretical approaches. Methods: theoretical provisions of regional and spatial economics, innovative development, and economic geography by Russian and foreign scientists were used for conducting the research. Тhe methods of bibliometric, statistical and content analysis of literary sources constituted a methodological framework for the study. A systematization of publications for 2012–2021 was grounded on thematic samples from eLIBRARY.ru, Scopus and Web of Science databases. An analysis of text array content was conducted with the aim of further critical interpretation of the revealed patterns and identifi cation of promising research directions. Results: it was found, that despite the fact that the concept of the smart specialization was based on many previous theoretical approaches, it made a signifi cant contribution to the new political vision of regional development. It is shown how the initially sectoral approach, through the use of the postulates of economic geography, was transformed into the territorial concept. The conducted bibliometric and content analyses of literary sources made it possible to identify the inherent characteristics of the concept, principles and tools for its implementation, as well as formulate the author’s defi nition of the smart specialization approach. Conclusions and Relevance: the importance of smart specialization consists of the following aspects. Firstly, substantiating the need for differentiated regional policy for various types of regional innovation systems. Secondly, scientifi c and practical substantiating the importance of the related diversifi cation approach to regional development to stimulate structural changes that are signifi cant for economic dynamics. Thirdly, focusing on interregional interaction to ensure complementarity of scientifi c and technological regional development.
The role of artificial intelligence in building an adaptive educational environment
Authors: Izmailova M. A. 
Published: April 2024

Purpose: of the article is to study the influence of artificial intelligence on the construction of an adaptive educational environment that takes into account the positive and negative impact of artificial intelligence, as the core of digital technologies, on the well-being of participants in the educational process. Methods: the work uses a complex of theoretical methods, including axiomatic, formalization, abstraction, logical analysis, historical retrospection. The most signifi cant practical research methods include statistical, operationalization and evaluation, comparative analysis. Results: the article provides a statistical substantiation of the demand for artifi cial intelligence in the education. The current educational problems are shown, in solving which it is advisable to use artifi cial intelligence. The article describes the trends in the use of artificial intelligence in the Russian education. The interpretation of the adaptive educational environment is given and the possibilities of using artificial intelligence as a tool for its construction are shown. The logical sequence for constructing an adaptive intelligent teaching system is proposed. The analysis of the impact of digital technologies used in hybrid learning (including artifi cial intelligence) on the well-being of participants in the educational process was carried out. The need for a rational, balanced and cautious approach to the use of artifi cial intelligence in education is emphasized, which gives rise to numerous ethical problems, ignoring which can negatively aff ect the values of education. Conclusions and Relevance: in the context of digitalization of the economy and society, the key technology of which is artifi cial intelligence, education is facing technological challenges that force it to adapt to new operating conditions. The penetration of artifi cial intelligence into the field of education is the pattern of scientific and technological progress that cannot be resisted. The positive aspects and threats of using artificial intelligence in education should be critically assessed, and informed decisions should be made on this basis. Considering the specifics of the educational environment in which the foundation of personality is laid, and the need to preserve the values of education as a factor of cultural progress, priority in goal-setting and the meanings of education should remain with a person whose assistant can be artifi cial intelligence.
Fintech Solutions for West African SMEs: Post-Crisis Challenges
Authors: Boubacar Emine Dahi, Mohamed 
Published: April 2024

Catalysts of economic growth worldwide, small and medium enterprises (SMEs) play a pivotal role in fostering job creation, social advancement, and innovation. In Africa, they account for 95% of job providers (World Trade Organization, 2022). Yet, SMEs often face significant hurdles, with limited access to finance being chief among them, especially in the aftermath of financial crises. Traditional banks, hampered by regulatory changes, have scaled back lending to SMEs, paving the way for Financial Technology (Fintech) firms to offer innovative financing solutions. Utilizing cutting-edge technology and varied business models, Fintech platforms provide SMEs with alternative financing options, including debt and equity financing. This disruption in the financial landscape holds promise for SMEs, liberating them from reliance on traditional banking channels and providing crucial capital for growth and expansion. SMEs can significantly contribute to achieving Sustainable Development Goals (SDGs), such as creating employment, reducing income inequality, and alleviating poverty (OECD, 2017).
The post-crisis era has not only hindered traditional financing avenues but also birthed new alternatives. These non-bank financing options empower SMEs by presenting fresh funding opportunities. While Fintech companies are thriving in developed nations, many developing countries are lagging. Despite the numerous benefits Fintech financing offers to SMEs, certain countries are slow to adopt them, hindering progress
Effect of Different Processing Temperature on Motility and Viability in Canary Sperm
Authors: Özkök A.O. 
Published: April 2024

Background: Canaries have attracted people’s attention with their colors, shapes and impressive songs. The fact that canaries are domesticated and easy to obtain has made these birds attractive for songbird studies. In our study, canary semen was examined at different temperature values. This study aims to determine the most efficient spermatozoa examination temperature in canaries. Methods: In this study, five different temperature values (36, 38, 40, 42 and 44°C) were determined. The study used 6 active male Gloster canaries in each group. After each semen collection application, a 3-day break was given for the birds to rest. Dulbecco’s Modified Eagle Medium (DMEM) expander, which is preferred by songbirds, was used in the research. The semen was diluted 1:2 in a water bath at specified temperatures (36, 38, 40, 42, 44°C) and immediately examined for motility and viability. Result: When the study results were evaluated, it was seen that the viability rate at 38°C was higher than the other groups and 40°C gave the highest results in terms of motility. In addition to the viability rate at 38°C, the swimming speed of spermatozoa was also found to be more stable over a wider area than other groups. As a result, based on the data obtained from the study, it can be said that the most appropriate temperature for motility and viability in canary spermatozoa is 38°C.
Geno-Species Composition of Borrelia Circulating on the Black Sea Coast of the Krasnodar Territory
Authors: Zaitseva O. A. , Volynkina A. S. , Vasil’eva O. V. , Chekhvalova E. V. , Kolosov A. V. , Prislegina D. A. , Manin E. A. , Kulichenko A. N. 
Published: April 2024

The aim of the study was to assess the current epidemiological situation on Ixodidae tick-borne borreliosis (ITBB) (2017–2022) on the Black Sea coast of the Krasnodar Territory, to study the species composition of Borrelia.Materials and methods. Ixodidae ticks, Ixodes ricinus, Haemaphysalis concinna, H. inermis, Rhipicephalus sanguineus, were examined for infection with tick-borne borreliosis pathogens, followed by DNA sequencing of isolates. Species identification of Borrelia was carried out based on analysis of the nucleotide sequence of the 16S rRNA gene fragment using BLAST algorithm. Additionally, the OspC genotype was determined for isolates of pathogenic genovariants through comparing the obtained sequences with reference ones in the MEGA 5 program. The data were processed applying the cartographic method using the QGIS 2.18 software.Results and discussion. Between 2017 and 2022, 101 cases were registered on the Black Sea coast of the Krasnodar Territory, which accounted for 1.6 % of all ITBB cases in the Krasnodar Territory. The number of complaints with tick bites in Sochi was up to 191.4 per 100 thousand population. During the study, the predominant Borrelia geno-species on the territory of the Black Sea coast of the Krasnodar Territory was determined using sequencing – Borrelia lusitaniae (78.1 %). The circulation of geno-species B. garinii (6.8 %), B. valasiana (5.7 %), B. afzelii (3.6 %), B. miyamotoi (2.6 %), B. tanukii, B. bissettii (1.6 % each) was also observed. For Borrelia pathogenic species, appurtenance to OspC geno-groups was ascertained: four isolates were assigned to invasive OspC geno-groups, of which three B. afzelii isolates were genogroup A8, one B. garinii isolate was G7. High rate of infection of ticks with Borrelia was recorded in the surveyed area (up to 94.5 %). Borrelia of pathogenic species account for only 10.4 % of the total number of isolates studied. Mostly, genovariants that rarely cause diseases in humans (B. lusitaniae, B. valasiana, B. bissettii) and non-pathogenic Borrelia (B. tanukii) were found, which indicates a low risk of infection with ITBB pathogens.
Genetic Profile of <I>Brucella melitensis</I> Strains Isolated on the Territory of the Russian Federation, Based on Analysis of Single Nucleotide Polymorphisms Following Whole Genome Sequencing
Authors: Kuznetsova I. V. , Kovalev D. A. , Pisarenko S. V. , Bobrysheva O. V. , Shapakov N. A. , Zhirov A. M. , Safonova N. S. , Ponomarenko D. G. , Khachaturova A. A. , Zhilchenko E. B. , Serdyuk N. S. , Kulichenko A. N. 
Published: April 2024

The aim of the work was to conduct a comparative phylogenetic analysis based on wgSNP of complete genomes of Brucella melitensis strains circulating in the territory of the Russian Federation.Materials and methods. wgSNP typing of 412 B. melitensis strains of the main genetic lineages of brucella from different regions of the world, including 64 strains isolated in the regions of the European and Asian parts of the Russian Federation, was performed. DNA sequencing was conducted on the “Ion GeneStudio S5 Plus” platform (“Life Technologies”, USA) using the “Ion Plus Fragment Library Kit library preparation” (“Life Technologies”, USA), according to the “Ion 520™ & Ion 530™ Kit – Chef” protocol (Revision D.0).Results and discussion. It has been established that the strains circulating in Russia belong mainly to genotype II, which has a wide geographical distribution across the territory of Eurasia. At the same time, subgenotype IIh prevails in the regions of Siberia, and Iii – in the European territory of the country. For the first time, sets of specific SNPs have been identified that allow for intraspecific differentiation of B. melitensis strains. The obtained results made it possible to determine the probable routes of introduction of the causative agent of brucellosis into the territory of the Russian Federation from China and the countries of the Middle East. The prospect of using an optimized wgSNP typing scheme to solve urgent problems in the field of molecular epidemiology of brucellosis is demonstrated. It includes determining the genotype and subgenotype of the pathogen associated with the probable geographical region of origin of infection, and identifying the genetic relations between strains with high accuracy.
Detection of Rickettsia species in rodents collected in the Northern provinces of Vietnam, 2020–2022
Authors: Toan Van Trinh , Cuong Viet Vo , Dat Van Nguyen , Lan Anh Thi Phan , Tan Ngoc Nguyen , Hung Viet Pham , Lan Anh Thi Le 
Published: April 2024

Rickettsiae, which are obligate intracellular bacterial parasites, have a life cycle commonly associated with arthropod vectors and animal hosts. Rodents are recognized as their natural reservoir hosts and play a role in transmitting the bacteria to humans through arthropod vectors. The true extent of rickettsial infections in Vietnam remains underestimated due to a limited understanding of the disease’s epidemiology, resulting in a significant public health burden.The aim of this investigation was to assess the prevalence of Rickettsia in wild-living rodents in Dien Bien, Son La, and Phu Tho provinces of Northern Vietnam between 2020 and 2022.Materials and methods. A total of 396 wild-living rodents were collected from the Northern provinces of Vietnam during 2020–2022. Real-time polymerase chain reaction (PCR) was employed to detect the percentage of Rickettsia-positive specimens. Subsequently, the ompB and 17kDa genes were extracted, amplified, and sequenced from the Rickettsia-positive rodents.Results and discussion. Among the 396 rodents examined, the majority were Rattus norvegicus (56.1%), followed by R. tanezumi (37.4%), R. nitidus (2.5%), and R. germaini (1.8%). R. korodentsensis and R. argentiverter constituted the remaining rodents, accounting for 2.2% of the total. The real-time PCR analysis revealed that 27 blood samples out of the 396 rodent samples collected, tested positive for Rickettsia (6.81%). R. germaini was shown to have the highest positive rate 1/8 (12.5%), followed by R. nitidus 1/10 (10.0%), R. tanezumi 14/149 (9.5%), and R. norvegicus 11/222 (4.9%). No other tick-borne pathogens were detected in any of the provinces. Sequencing of the positive samples as regards the ompB and 17kDa genes revealed the closest relation to R. felis. These findings highlight the potentially high risk of R. felis infection in humans and animals within the studied areas.