bluuebunny/crossref_metadata_2025_split huggingface dataset:
Material safety data sheets and allergic contact dermatitis: A misleading case
Authors: Nixon Rosemary L 
Published: June 2007

SUMMARYA 33‐year‐old welder had previously been identified with an allergy to epoxy resin. When the cause of his recurrent skin eruption was being investigated, it was found that the putty he was using at work contained epoxy resin, which was not listed on the material safety data sheet.
Dermal connective tissue metabolism in photoageing
Authors: Miyachi Yoshiki , Ishikawa Osamu 
Published: June 2007

SUMMARYThe term photoageing describes the clinical and histological cutaneous changes that are the consequence of repeated chronic sun exposures and are qualitatively different from those observed in chronological ageing. The connective tissue of the skin is composed mainly of collagen, glycosaminoglycans and elastin and, thus, alterations of these components in photoageing are briefly reviewed in the present article. Collagen changes in photoageing are partly explained by crosslinks as well as the unbalanced regulation of collagen production and breakdown. Some visible skin changes can be induced by the consequence of dermal glycosaminoglycans, because the total amount, as well as the composition of the main disaccharide units, is significantly altered in the exposed sites of both aged people and photoaged mice. As for the mechanism of solar elastosis, increased elastin mRNA levels resulting from transcriptional up‐regulation of the gene have been reported. Taken together, all components of the dermal connective tissue are affected by chronic actinic damage; however, further in vitro investigation is required to unmask the exact events in photoageing. With regard to this, our novel three‐dimensional culture system should be of great help because it mimics the in vivo condition by sell producing the extracellular matrices.
Hypertrophic lichen planus mimicking squamous cell carcinoma
Authors: Tan Ernest , Malik Rita , Quirk Christopher J 
Published: June 2007

SUMMARYAn 87‐year‐old female presented with a 3 month history of hyperkeratotic nodules on her left shin. An initial clinical and histological diagnosis of multiple squamous cell carcinomas on the left shin was made. Review of the biopsy, however, showed hypertrophic lichen planus with pseudoepitheliomatous hyperplasia. Typical lichen planus was seen affecting the oral mucosa, nails and skin elsewhere.
Intralesional bleomycin
Authors: Dyall‐Smith Delwyn 
Published: June 2007

SUMMARYThe use of intralesional bleomycin to treat Bowen's disease of the palm affection a motor mechanic is presented. Bleomucin in 1% lignocaine was injected at 3‐6 week intervals showed no local recurrence and no long‐ term Adverse events.
Botulinum toxin for the correction of hyperkinetic facial lines
Authors: Goodman Greg 
Published: June 2007

SUMMARYThe present article illustrates the elects of low dose botulinum toxin (BTx) injections For the improvement of hyperkinetic fecial lines and presents a grading treatment chart designed to standardize the reporting of the improvement seen. A questionnaire of patient acceptance, the patients' impression of therapy and short‐term results and complications are reported. Twelve patient with 26 injected‐paired regions were charted and the response to injection was graded. Patients had hyperkinetic Facia lines in glabella, periorbital regions or horizontal Forehead lines. Diluted BTx type A (1 IU/0.1.ml.) was injected and patients were assessed at 10 days. A second follow up injection was offered So patients at this stage if required. Objectively, all patients' hyperkinetic actions and lines improved or diminished. The degree of improvement was similar in all areas injected and a symmetry of results was always observed. In a minority of cases, all movement was lost (7/26) and in others it was weakened but present (19/26). In some injected areas the actual expression line that was visible at rest disappeared entirely (11/26); in the others it was diminished (15/26). Complications were Few. Two patients had temporary‐brow ptosis that spontaneously recovered within the first week. No eyelid ptosis was noted. Bruising arid headaches were the most common reported complications. I. Low dose BTx is an effective and well‐tolerated treatment for hyperkinetic facial lines with few significant complications in this small pilot study. The grading chart may allow easier comparisons of results between studies on the effects of BTx therapy.
Brachioradial pruritus and cervical spine manipulation
Authors: Tait Clare P , Grigg Edward , Quirk Christopher J 
Published: June 2007

SUMMARYBrachioradial pruritus (BRP) causes significant morbidity in the majority of patients for whom no effective treatment is found. Chronic ultraviolet radiation exposure has usually been cited as the cause, but nerve damage from cervical spine disease has also been implicated. We report on a small retrospective exploratory study, conducted by questionnaire, of a group of patients who were treated with a specific cervical spine manipulation. Ten of 14 patients reported resolution of symptoms following manipulative treatment. All six patients who had had previous cervical spine disease responded to manipulation, as did half the remaining eight patients who had no previous history of neck symptoms. Although patients with BRP, by definition, share similar symptoms, the aetiology is almost certainly multifactorial. Prospective studies looking for cervical spine disease, as well as assessment of this particular method of cervical spine manipulation as a treatment modality for BRP, should be considered.
Mycobacterium marinum: Chronic and extensive infections of the lower limbs in South Pacific Islanders
Authors: Lee Michael W , Brenan John 
Published: June 2007

SUMMARYWe report three adult cases of very chronic, extensive Infection of the lower limbs due to Mycobacterium marinum.The patients were from South Pacific islands and, clinically, the widespread warty plaques resembled chromomycosis. One was associated with severe lymphoedema All three patients gave a history of at least 20 years duration. The patients were otherwise well and not Immunologically compromised. In all eases, the organism was identified on tissue cultures and was not seen on histopathology.The mycobacteria were sensitive to most antibiotics tested in vitro. The patients were treated with a combination of rifampicin and cotrimoxazole with good results.
Benign lichenoid keratosis due to constant pressure
Authors: Ramesh V , Kulkarni SB , Misra KS 
Published: June 2007

SUMMARYTwo well‐circumscribed keratotic plaques in an elderly man, one each on symmetrically. identical over the sides of the buttocks, are described. Clinical and histopathological features supported the diagnosis of benign lichenoid keratosis, which had probably resulted from constant pressure over the site and regressed when this factor was eliminated.
Novelty shop ‘itching powder’
Authors: Albert Michael R 
Published: June 2007

SUMMARYTo evaluate causes of Itch, commercial ‘itching; powders’ were sought for evaluation. Only one product, produced in Germany and consisting of ground rose hips, is currently sold in novelty shops in the Boston area. These plant fibres appear to provoke itch and prickle sensations by non‐allergic mechanical stimulation, similar to the action of wool fibres.
Tea tree oil allergy: What is the offending agent? Report of three cases of tea tree oil allergy and review of the literature
Authors: Rubel Diana M , Freeman Susanne , Southwell Ian A 
Published: June 2007

SUMMARYTea tree oil is currently enjoying popularity as a cureall for a variety of skin conditions, from infections to psoriasis, and many household and personal products containing Melaleuca oil are available. However, despite its chemical complexities and enthusiastic use, there have been only a few reports of allergic reactions lo lea tree oil. At the Skin and Cancer Foundation (Sydney, NSW, Australia), three of 28 normal volunteers tested strongly positive to patch testing with tea tree oil. Following farther patch testing with tea tree oil constituents, all three patients reacted strongly to two preparations containing sesquiterpenoid fractions of the oil. Because patients often neglect to mention that they have used “natural” remedies, it is important that physicians are aware of the potential adverse effects of these products. Furthermore, identification of the allergenic ingredients in lea tree oil may assist the growing industry to produce safer products.
Pyogenic granuloma‐like lesions in a patient using topical tretinoin
Authors: MacKenzie‐Wood Andrew R , Wood Glenda 
Published: June 2007

SUMMARYA 16‐year‐old male developed numerous pyogenic granuloma like‐lesions across his neck, chest and back after 6 weeks isotretinoin therapy for cystic acne. The isotretinoin was ceased and he was commenced on oral steroids. After 6 weeks, the lesions were almost completely healed. However, due to worsening comedonal acne, the patient was commenced on topical tretinoin cream 0.03% twice daily to his chest. He was reviewed 2 weeks later and, surprisingly, 2 new pyogenic granuloma‐like lesions had developed on his chest. These lesions persisted until the topical tretinoin was ceased 3 months later.
Three cases of verrucous carcinoma
Authors: Dogan Gursoy , Oram Yasemin , Hazneci Ersoy , Özen Suleyman , Karincaoǧlu Yelda , Ciralik Harun 
Published: June 2007

SUMMARYVerrucous carcinoma of the skin and mucosa is an uncommon clinicopathological variant of low grade squamous cell carcinoma. Here, we present three different clinical types of verrucous carcinoma. The first patient presented with an anogenitial verrucous carcinoma, also known as Buschke‐Loewenstein tumour. The second patient had verrucous carcinoma of the heel with endophytic growth (i.e. epithelioma cuniculatum) and the third patient had gluteal verrucous carcinoma with a cauliflower‐like appearance. Clinically, the lesion of the first patient best resembled giant condyloma accuminatum without any prominent verrucous component, whereas the second patient showed a big deep ulcer on the heel. None of the patients had metastasis. The diagnosis was confirmed with biopsy and total excision was performed in all cases. Although the cases have different clinical presentations in different locations, we think that they should be considered as a single entity: that is, verrucous carcinoma.
Cicatricial pemphigoid rarely involves the scalp
Authors: Ball Sally , Walkden Valerie , Wojnarowska Fenella 
Published: June 2007

SUMMARYWe present a case of cicatricial pemphigoid with significant scarring alopecia as a major manifestation and review our series of cicatricial pemphigoid patients in Oxford (UK). Only lour of 54 patients had scarring alopecia of the scalp. While rare, this manifestation poses a difficult management problem; patients find this cosmetically distressing and there are no successful treatments available to date.
Primary cutaneous B cell lymphoma: Outcomes and treatment
Authors: Wong Kenneth C , Weller Paul A 
Published: June 2007

SUMMARYThis retrospective study documents six patients with primary cutaneous follicular centre cell lymphoma (FCCL) of the head and trunk. The hack was the most common site of presentation of the primary. Despite a good response to initial therapy, cutaneous relapses were common and one patient developed lymph node metastases. Intralesional steroids may be effective in controlling localized skin relapses of this B cell lymphoma. All patients are currently alive with two surviving over 5 years.
Topical eucalyptus oil poisoning
Authors: Darben Troy , Cominos Belle , Lee CT 
Published: June 2007

SUMMARYEucalyptus oil is well documented as being extremely toxic if ingested. We report a case of systemic eucalyptus oil toxicity from topical application. A 6‐year‐old girl presented with slurred speech, ataxia and muscle weakness progessing to unconsciousness following the widespread applicantion of a home remedy for urticaria containing eucalyptus oil. Six hours following removal of the topical preparation her symoptoms had resolved, with no long‐term sequelae.
A possible sympathetic cholinergic mechanism in the renal reflex elicited by stimulation of abdominal viscera in the dog
Authors: Liang C. C. 
Published: June 2007

SUMMARY1. Isolated blood‐bathed tissues which were superfused with renal venous blood during various manipulations of the visceral organs of dogs showed no detectable pharmacologically active substances, except a noradrenaline‐like substance which was liberated under some conditions of manipulation.2. An acetylcholine‐like substance was liberated into renal venous blood during experimental manipulation of visceral organs in dogs during infusion of physostigmine; the acetylcholine activity was detected with the dorsal muscle of the leech.3. The amount of liberated acetylcholine‐like substance depended on the strength of visceral stimulation as judged by the changes in the hepatic portal venous pressure. Strong reflex stimulation produced the release not only of acetylcholine but also of noradrenaline.4. Physostigmine augmented and prolonged the reflexly induced renal vasodilator and diuretic responses, and these were abolished by atropine. It was suggested that the reflex involves a cholinergic nervous mechanism.5. In some dogs there was a high output of acetylcholine from the kidney during visceral stimulation, and this was accompanied by a decrease in urine flow. The reason was not known.6. Prostaglandin E1 administered into the renal artery produced similar vasodilator and diuretic responses to acetylcholine, but the onset of the effects were slower and they persisted longer than those produced by acetylcholine.
The effect of chronic cardiac volume overload on regional myocardial blood flow in the dog
Authors: Hodge Andrew J. , Lloyd Brian L. , Wyburn John R. , Taylor Roger R. 
Published: June 2007

SUMMARY1. Regional myocardial blood flow was studied in the anaesthetized, open‐chest dog with a large chronic aorto‐caval fistula, using carbonized microspheres of 7–10 μm diameter. The results from fourteen dogs with fistulae of 4–84 days duration were compared to those from nine normal animals.2. Myocardial blood flow to all areas of both ventricles was increased to between 180 and 250% of the normal despite lower aortic diastolic (coronary diastolic) pressure. Myocardial blood flow in the right ventricle was lower than in the left in both groups of dogs although the increase above normal in dogs with fistulae was relatively greater in the right ventricle. Increased myocardial blood flow is attributed to coronary autoregulation resulting from increased myocardial oxygen consumption due to increase in myocardial tension development.3. Although absolute blood flow to the inner left ventricular wall was markedly increased in all dogs with fistulae, in those with aortic diastolic pressure below 55 mmHg the ratio of flow in the inner to that in the outer free left ventricular wall was significantly less than in those with aortic diastolic pressure above 55 mmHg (P < 0·02). Low aortic diastolic pressure and diastolic coronary perfusion pressure probably resulted in relative ischaemia of the inner left ventricular wall.
Effect of equivalent antihypertensive doses of mefruside and cyclopenthiazide on serum electrolytes, uric acid and glucose tolerance in hypertensive patients
Authors: Waal‐Manning Hendrika J. 
Published: June 2007

SUMMARY1. A comparative cross‐over trial of mefruside and cyclopenthiazide, each drug being given for 6 weeks, was conducted on thirty hypertensive patients with diabetes mellitus or impaired glucose tolerance. Other antihypertensive therapy, any antidiabetic therapy and potassium supplementation were kept constant throughout the trial. Dosages of mefruside and cyclopenthiazide were adjusted to give approximately equal blood pressure levels in the two drug periods.2. There was no significant difference in the following parameters studied during the sixth week of each of the two periods of drug therapy: serum electrolytes, total CO2, chloride, urea, amylase, haemoglobin, erythrocyte sedimentation rate, platelet and white blood cell counts, lying and standing blood pressure and pulse rate, weight, fasting and 2‐h glucose and insulin levels and five‐value glucose and insulin curve areas, fasting calcium and phosphate.3. Serum creatinine and uric acid showed a small but significant fall during mefruside therapy.
Clearance from the circulation of the rat and whole‐body autoradiography in the mouse of 125I‐labelled neurophysins
Authors: Morris B. J. , Cross Shirley A. M. , Johnston C. I. 
Published: June 2007

SUMMARY1. The rate of clearance of 125I‐labelled porcine neurophysins I and II from the circulation of the rat has an initial fast component followed by a slower component.2. In the initial phase of clearance the half‐life of neurophysin I was 1·50 min (s.e.m. = 0%%03) and for neurophysin II was 1·74 min (s.e.m. = 0·05). In the slower phase of clearance the half‐life of neurophysin I was 22·6 min (s.e.m. = 2·2) and for neurophysin II was 27·3 min (s.e.m. = 5·8).3. The first component had a volume of distribution similar to the blood volume and the second component had a volume of distribution similar to the volume of extracellular fluid of the rat.4. The metabolic clearance rates per 200 g of body weight were 1·94 ml/min (s.e.m. = 0·12) for neurophysin I and 1·29 ml/min (s.e.m. = 0·15) for neurophysin II.5. Using whole‐body autoradiography, the kidney was shown to be the major site of uptake of radioactivity in both virgin female and lactating mice.
Potentiation of antinociceptive action of morphine by prostaglandin E1 in albino rats
Authors: Bhattacharya S. K. , Reddy P. K. S. P. , Debnath P. K. , Sanyal A. K. 
Published: June 2007

SUMMARY1. Prostaglandin E1 (0·4 mg/kg, i.p.) significantly potentiated the antinociceptive action of morphine in albino rats.2. This potentiation was significantly inhibited by pretreatment with reserpine, p‐chlorophenylalanine or methysergide but not by α‐methyl‐p‐yrosine, phentolamine or propranolol.3. The results suggest that the potentiation of morphine by prostaglandin E1 is mediated by serotonin, since it is inhibited by pharmacological agents known to reduce central turnover of serotonin receptors.
Some pharmacological effects of δ‐aminolaevulinic acid on blood pressure in the rat and on rabbit isolated ear arteries
Authors: McGillion F. B. , Moore M. R. , Goldberg A. 
Published: June 2007

SUMMARY1. The effects of δ‐aminolaevulinic acid (ALA) have been examined on the blood pressure of anaesthetized rats and pithed rats and on the perfusion pressure in isolated preparations of the rabbit ear artery.2. ALA has a hypotensive effect in both anaesthetized and pithed rats.3. In anaesthetized rats, the hypotensive response was produced with either continuous infusion or single injections of ALA, and was not blocked by hexamethonium, propanolol, phentolamine, atropine or mepyramine.4. In the pithed rat, ALA had no effect on the pressor response to nicotine.5. The hypotensive response to ALA could be counteracted by the pressor effect of adrenaline or noradrenaline. In pithed rats, the pressor response of vasopressin was reduced by ALA.6. Vasoconstrictor response of the isolated perfused rabbit ear artery to noradrenaline and sympathetic nerve stimulation were usually not affected by ALA, but in a few experiments they were increased. ALA produced an increase in perfusion pressure in a few experiments.7. Since ALA appears to cause an increase in capillary permeability, it is probable that the hypotensive effect is associated with capillary dilatation.
The effect of heart rate on indices of myocardial contractility in the dog
Authors: Richmond D. R. , Angus J. A. , Goodman A. H. , Cobbin L. B. 
Published: June 2007

SUMMARY1. Changes in heart rate were evoked by atrial pacing in anaesthetized dogs with no pretreatment and in dogs given reserpine or guanethidine for 72 h. The effect of alterations in heart rate were related to two indices of myocardial contractility: the maximal rate of change of left ventricular pressure (dp/dt), and an index which was independent of initial fibre length (dp/dt)/ITT, where IIT is integrated isometric tension.2. An increase in heart rate in control dogs was accompanied by a rise in both dp/dt and (dp/dt)/IIT confirming that the Bowditch staircase does exist in the intact ventricle. The regression line relating heart rate to (dp/dt)/IIT was significantly steeper than that relating heart rate to dp/dt because the reduction in left ventricular preload at high heart rate tends to attenuate the rise in dp/dt.3. Reserpine, but not guanethidine pretreatment was accompanied by either a slight decrease or no change in (dp/dt)/IIT during pacing.4. Acute elevation of (dp/dt)/IIT by either calcium or isoprenaline infusion in reserpine pretreated dogs did not restore the Bowditch effect.5. Acute depression of (dp/dt)/IIT by propranolol and pentobarbitone was accompanied by a greater rise in (dp/dt)/IIT with pacing in control dogs and a rise rather than a fall in reserpine‐pretreated dogs.
The cardiovascular effects of intraventricular 5,6‐dihydroxytryptamine in conscious hypertensive rats
Authors: Finch L. 
Published: June 2007

SUMMARY1. Conscious experimental hypertensive rats injected intraventricularly with 5,6‐dihydroxytryptamine (50 μg) responded with a rapid and long‐lasting (4 days) fall in blood pressure and this was accompanied by a bradycardia of similar duration.2. The acute actions of 5,6‐dihydroxytryptamine on the cardiovascular system were not modified by pretreatment with bromolysergide (0·5 mg/kg, i.p.), methysergide (2·5 mg/kg, i.p.) or intraventricular phentolamine (200 μg).3. The results suggest that central serotonergic neurones play an important role in the regulation of blood pressure. However, the site of action remains to be investigated.
Interaction between drugs and potassium‐rich solutions in producing contraction in bovine tracheal smooth muscle: studies in normal and calcium‐depleted tissues
Authors: Kirkpatrick C. T. , Jenkinson Hilary A. , Cameron A. R. 
Published: June 2007

SUMMARY1. The contracture normally induced in isolated bovine tracheal smooth muscle by potassium‐rich solution was abolished by removal of the extracellular calcium. The contraction returned when calcium was added to the solution in a concentration greater than 0·05 mmol/l.2. The amplitudes of the potassium‐contracture, and of the contractile responses to histamine and acetylcholine in normal physiological solutions, declined at low temperatures (15–25°C). If drugs were added during the plateau phase of the potassium contracture, the extra tension developed above the contracture did not change with temperature.3. Calcium‐depletion reduced the responses to drugs, and repeated application of the drugs in calcium‐free solution produced progressively smaller contractions, suggesting that an intracellular store of calcium was being used up.4. Depolarization of calcium‐depleted tracheal muscle by high‐K+ solution without calcium produced responses to drugs which were larger than those in sodium‐based calcium‐free solutions. There was no potentiation in a solution in which sodium was replaced by sucrose, suggesting that potassium was not acting simply by replacing the sodium.5. It is suggested that depolarization of the membrane by potassium makes available a fraction of bound calcium which was not available in calcium‐free sodium‐based solution.