bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deficiency of peripheral CLA+ Tregs and clinical relevance in Behcet’s syndrome
Authors: Li Jiachen , Sun Feng , Zhu Danxue , Hou Yuke , Cheng Gong , Wang Ping , Jin Xu , Zhou Wenyan , Sun Xiaolin , Li Zhanguo , Liu Tian 
Published: March 2024

Abstract
Background
Autoimmune responses have been suggested to involvement in patients with Behcet’s syndrome (BS). There has been growing attention towards the roles of cutaneous lymphocyte antigen (CLA)+ regular T cells (Tregs) in autoimmune diseases. The role of CLA+ Tregs in BS is still uncertain. This study aims to clarify the impact of CLA+ Tregs on BS.

Methods
We collected peripheral blood from a total of 107 patients with BS and 114 healthy controls (HCs). The number of CLA+ Tregs, natural killer (NK) cells, B cells, and several subtypes of CD4+ T cells were detected using flow cytometry and compared between patients and HCs.

Results
The absolute number and proportion of CLA+ Tregs among CD4+ T lymphocytes and CD4+ Tregs were lower in patients with BS than in HCs. CLA+ Tregs were positively related with NK cells (r = 0.500, P < 0.001) and B cells (r = 0.470, P < 0.001) and negatively related with effector T cells (r=-0.402, P < 0.001) in patients with BS. Patients with BS and arterial aneurysms had CLA+ Treg cell deficiency. A decreased proportion of CLA+ Tregs was associated with arterial aneurysms in patients with BS. The proportion of CLA+ Tregs in patients with BS increased with corticosteroids and immunosuppressants.

Conclusion
CLA+ Tregs decrease in association with arterial aneurysm in patients with BS. CLA+ Tregs may be a predictor of response to BS treatment.
Diagnostic dilemma in maxillofacial pathologies: a case series
Authors: Sarda Pavithra , Gurram Prashanthi , Ramakrishnan Karthik , Narayanan Vivek , Chandran Saravanan , Vinayachandran Divya 
Published: March 2024

Abstract
Background
Head and neck are a site of numerous pathologies with different aetiologies and presentations. Rare pathologies, although infrequent still do exist. Diagnostic dilemma in maxillofacial pathologies can be the most challenging situation. Dealing with uncertainty, although difficult, is a reality in surgical practice. Being thorough, attentive to details and clues, and maintaining an open mind are critical strategies in the approach to such a patient.

Case presentation
In our paper we are reporting a spectrum of 4 unusual variants of head and neck pathologies, whose age and sex were 52 years/ M, 37 years/F, 41 years/ F, 30 years/F respectively. All the patients were of Indian origin. The diagnosis ranged from autoimmune diseases to lymphatic cancer which posed a unique challenge both in the terms of diagnosis and management.

Conclusion
A thorough systematic evaluation along with a multidisciplinary approach is mandatory in the diagnosis of unusual head and neck pathologies.
Provider perceptions of systems-level barriers and facilitators to utilizing family-based treatment approaches in adolescent and young adult opioid use disorder treatment
Authors: Pielech Melissa , Modrowski Crosby , Yeh Jasper , Clark Melissa A. , Marshall Brandon D. L. , Beaudoin Francesca L. , Becker Sara J. , Miranda Robert 
Published: March 2024

Abstract
Background
Amidst increasing opioid-related fatalities in adolescents and young adults (AYA), there is an urgent need to enhance the quality and availability of developmentally appropriate, evidence-based treatments for opioid use disorder (OUD) and improve youth engagement in treatment. Involving families in treatment planning and therapy augments medication-based OUD treatment for AYA by increasing treatment engagement and retention. Yet, uptake of family-involved treatment for OUD remains low. This study examined systems-level barriers and facilitators to integrating families in AYA OUD treatment in Rhode Island.

Methods
An online survey was administered to clinic leaders and direct care providers who work with AYA in programs that provide medication and psychosocial treatments for OUD. The survey assessed attitudes towards and experiences with family-based treatment, barriers and facilitators to family-based treatment utilization, as well as other available treatment services for AYA and family members. Findings were summarized using descriptive statistics.

Results
A total of 104 respondents from 14 distinct treatment programs completed the survey. Most identified as White (72.5%), female (72.7%), and between 25 and 44 years of age (59.4%). Over half (54.1%) of respondents reported no experience with family based treatment and limited current opportunities to involve families. Barriers perceived as most impactful to adopting family-based treatment were related to limited available resources (i.e. for staff training, program expansion) and lack of prioritization of family-based treatment in staff productivity requirements. Barriers perceived as least impactful were respondent beliefs and attitudes about family-based treatment (e.g., perception of the evidence strength and quality of family-based treatment, interest in implementing family-based treatment) as well as leadership support of family-based treatment approaches. Respondents identified several other gaps in availability of comprehensive treatment services, especially for adolescents (e.g. services that increase social recovery capital).

Conclusions
Family-based treatment opportunities for AYA with OUD in Rhode Island are limited. Affordable and accessible training programs are needed to increase provider familiarity and competency with family-based treatment. Implementation of programming to increase family involvement in treatment (i.e. psychoeducational and skills-based groups for family members) rather than adopting a family-based treatment model may be a more feasible step to better meet the needs of AYA with OUD.
Trial registration: not applicable.
Validation of a size exclusion method for concomitant purification and formulation of peptide radiopharmaceuticals
Authors: Martin Sebastian , Wendlinger Lennard , Litvinenko Alexandra , Faizova Radmila , Schottelius Margret 
Published: March 2024

Abstract
Background
Both in clinical routine and in preclinical research, the established standard procedure for the final purification of radiometal-labeled peptide radiopharmaceuticals is cartridge-based reversed-phase (RP) solid phase extraction (SPE). It allows the rapid and quantitative separation of the radiolabeled peptide from hydrophilic impurities and easy integration into automated synthesis procedures. However, product elution from RP cartridges necessitates the use of organic solvents and product recovery is sometimes limited. Thus, an alternative purification method based on commercially available size exclusion cartridges was investigated.

Results
Since most peptide radiopharmaceuticals have a molecular weight > 1 kDa, Sephadex G10 cartridges with a molecular size cut-off of 700 Da were used for the final purification of a broad palette of 68Ga-, 64Cu- and 99mTc-labeled experimental peptide radiotracers as well as the clinically relevant ligand PSMA-617. Results (radiochemical purity (RCP, determined by ITLC), recovery from the solid support) were compared to the respective standard RP-SPE method. Generally, retention of unreacted 68Ga, 64Cu and 99mTc salts on the G10 cartridges was quantitative up to the specified elution volume (1.2 mL) for 68Ga and 99mTc and 99.6% for 64Cu. Even at increased elution volumes of 1.5-2 mL, RCPs of the eluted 68Ga- and 99mTc -radiopeptides were > 99%. For all peptides with a molecular weight ≥ 2 kDa, product recovery from the G10 cartridges was consistently > 85% upon respective adjustment of the elution volume. Product recovery was lowest for [68Ga]Ga-PSMA-617 (67%, 1.2 mL to 84%, 2 mL). The pH of the final product solution was found to be volume-dependent (1.2 mL: pH 6.3; 1.5 mL: pH 5.9; 2 mL: pH 5.5). Notably, the G10 cartridges were reused up to 20 times without compromising performance, and implementation of the method in an automated radiosynthesis procedure was successful.

Conclusions
Overall, size exclusion purification yielded all peptide radiopharmaceuticals in excellent radiochemical purities (> 99%) in saline within 10–12 min. Although product recovery is marginally inferior to classical SPE purifications, this method has the advantage of completely avoiding organic solvents and representing a cost-effective, easy-to-implement purification approach for automated radiotracer synthesis.
The challenge of using patient reported outcome measures in clinical practice: how do we get there?
Authors: Cella David , Nolla Kyle , Peipert John Devin 
Published: March 2024

Abstract
Background
As patient-reported outcome measures (PROMs) become available to clinicians for routine clinical decision-making, many wonder how to define a meaningful change in a patient’s PROM score. Some PROMs have a specific threshold that indicates meaningful change, but since those numbers are based on population averages, they do not necessarily apply to the varying experiences of each individual patient. Rather than viewing this as a weakness of PROMs, it is worth considering how clinicians use other existing measures in clinical decision-making—and whether PROMs can be used similarly.

Body
An informal survey of 43 clinicians reported using measures such as weight, blood pressure, and blood chemistry to inform clinical decision-making. Although clinicians were very consistent with what constituted a meaningful change for some measures (e.g., ECOG performance status), other measures had considerable variability (e.g., weight), often informed by their specialization (for example, differing thresholds for meaningful weight change for adult primary care, pediatrics, and oncology). For interpreting change in measures, they relied on clinical experience (44%), published literature (38%), and established guidelines (35%). In open-response comments, many clarified that the results of any measure had to be taken in the context of each individual patient before making treatment decisions. In short, clinicians already apply individualized clinical judgment when interpreting score changes in existing clinical measures. As clinicians gain familiarity with PROMs, PROMs will likely be utilized in the same way.

Conclusion
Like other clinical measures from weight to blood chemistry, change in a PROM score is but one piece of a patient’s clinical story. Rather than relying on a hard-and-fast number for defining clinically meaningful change in a PROM score, providers should—and many already do—consider the full scope of a patient’s experience as they make treatment decisions.
Hip-specific and generic patient-reported outcome measure scores after primary hip replacement are associated with early revision surgery: a national registry study
Authors: Ackerman Ilana N. , Cashman Kara , Lorimer Michelle , Heath Emma , Harris Ian A. 
Published: March 2024

Abstract
Background
The ability to efficiently identify patients at higher risk of poor outcomes after joint replacement would enable limited resources for post-operative follow-up to be directed to those with the greatest clinical need. This is particularly important as joint replacement rates continue to grow internationally, stretching health system capabilities. Patient-reported outcome measures (PROMs) are routinely administered in many settings and offer an opportunity to detect suboptimal patient outcomes early. This study aimed to determine whether hip-specific and generic PROM scores are associated with early revision hip replacement within six to 24 months after the primary procedure.

Methods
Pre-operative and six-month post-operative PROM scores for patients undergoing primary total hip replacement (THR) were obtained from the Australian Orthopaedic Association National Joint Replacement Registry and Arthroplasty Clinical Outcomes Registry National and linked to revision surgery data. Clinically important improvement was defined using anchor-based thresholds. Associations between PROM scores (hip pain, Oxford Hip Score, HOOS-12, EQ-5D-5L, EQ VAS, patient-perceived change, satisfaction) and revision surgery were evaluated using t-tests, chi-square tests and regression models.

Results
Data were analysed for 21,236 primary THR procedures between 2013 and 2022. Eighty-eight revision procedures were performed at six to 24 months. Patients who were revised had more back pain and worse HOOS-12 scores pre-operatively but between-group differences were small. Worse post-operative PROM scores (hip pain, Oxford, HOOS-12, EQ-5D-5L, EQ VAS) were associated with early revision, after adjusting for age and sex (p < 0.001 for all analyses). Patient dissatisfaction (relative risk (RR) 10.18, 95%CI 6.01–17.25) and patient-perceived worsening (RR 19.62, 95%CI 11.33–33.98) were also associated with a higher likelihood of revision. Patients who did not achieve clinically important improvement in hip pain, function, or quality of life had a higher revision risk (RRs 2.54–5.64), compared with those who did (reference).

Conclusion
Six-month hip-specific and generic PROM scores can identify patients at higher risk of early revision surgery. Our data highlight the utility of routine post-operative PROM assessment for signaling suboptimal surgical outcomes.
Nahua Fasting in a Series of Don'ts: An Interpretation of the Precontact Nezahualiztli Practice
Authors: Madajczak Julia 
Published: March 2024

Abstract
Although the precontact Nahua nezahualiztli ritual received significant coverage in historical sources, the Christian discourse of these sources misinterpreted it as either fasting or penance, inscribing nezahualiztli in the Western idea of the sacred. In order to learn more about the Nahua worldview, this article uses methods derived from philology, cognitive linguistics, and anthropology to reconstruct the meaning that nezahualiztli had for the precontact Nahua. I review numerous mentions of this ritual in the sources and discuss three examples involving nezahualiztli. I conclude that avoiding some hygienic practices, fasting, and abstaining from sex, among other forms of abstinence, allowed humans to assimilate with the deities and dead who inhabited the world beyond. The Nahua observed nezahualiztli whenever they needed to enter a liminal state, such as during funerals, travel, or creative actions. This insight adds to our understanding of the Nahua sacred, particularly the relationship between humans and gods.
The “Indios” of Spain and the Mexican Revolution: Racial Ideologies and the Labor of Internationalist Solidarity
Authors: Aguilar Kevan Antonio 
Published: March 2024

Abstract
This article examines the influence of the Mexican Revolution (1906–40) on Spanish anarchists’ views on racial and class solidarity. Whereas recent transnational studies of the Spanish Civil War (1936–39) have highlighted the conflict's lingering imprint on Latin American politics and society, this essay explores why Spanish anarchists interpreted the Mexican Revolution as an insurrection led by Mexico's Indigenous communities. It argues that such readings of the conflict, most of which were advanced by non-Indigenous revolutionaries, both challenged and reinforced racialized notions of social and political upheaval. This article therefore demonstrates how these views challenged orthodox interpretations of social revolution while exposing the obstacles to building internationalist solidarity among laboring classes in postimperial and postcolonial societies.
A Rad50-null mutation in mouse germ cells causes reduced DSB formation, abnormal DSB end resection and complete loss of germ cells
Authors: Liu Yuefang , Lin Zhen , Yan Junyi , Zhang Xi , Tong Ming-Han 
Published: March 2024

ABSTRACT
The conserved MRE11-RAD50-NBS1/Xrs2 complex is crucial for DNA break metabolism and genome maintenance. Although hypomorphic Rad50 mutation mice showed normal meiosis, both null and hypomorphic rad50 mutation yeast displayed impaired meiosis recombination. However, the in vivo function of Rad50 in mammalian germ cells, particularly its in vivo role in the resection of meiotic double strand break (DSB) ends at the molecular level remains elusive. Here, we have established germ cell-specific Rad50 knockout mouse models to determine the role of Rad50 in mitosis and meiosis of mammalian germ cells. We find that Rad50-deficient spermatocytes exhibit defective meiotic recombination and abnormal synapsis. Mechanistically, using END-seq, we demonstrate reduced DSB formation and abnormal DSB end resection occurs in mutant spermatocytes. We further identify that deletion of Rad50 in gonocytes leads to complete loss of spermatogonial stem cells due to genotoxic stress. Taken together, our results reveal the essential role of Rad50 in mammalian germ cell meiosis and mitosis, and provide in vivo views of RAD50 function in meiotic DSB formation and end resection at the molecular level.
Enhancing Customer–Supplier Coordination Through Customer-Managed Inventory
Authors: Chen Shi , Cohen Morris A. , Lee Hau 
Published: March 2024

In recent years, there has been an increasing trend in supply chains to employ a “control tower” approach to improve supply chain performance. One such strategy is customer-managed inventory (CMI) in which the customer (the downstream party) controls the inventory of the supplier (the upstream party). However, the optimal design of the inventory control policy and the required incentive structure for CMI has not been fully explored in the related literature. In this paper, we develop a two-echelon model consisting of a supplier and a customer that captures the interaction between both decision makers. Analysis of this model indicates that achieving the potential benefits of CMI requires suitable incentive mechanisms to be put in place. The two-echelon inventory system model, however, does not give closed-form solutions, which are required to generate an optimal solution to the inventory control and incentive problem. To address this challenge, we propose an approximate model, which decouples the two-echelon model into two newsvendor-type models with each party operating a single-echelon system. This approximate model requires the introduction of additional cost parameters so that the decoupled model captures the cost implications of supplier shortages in the original two-echelon model. By developing appropriate values for these cost parameters, the approximate model yields near optimal results. Analysis of the solution reveals important operational factors that determine which environments are conducive for CMI and conditions for Pareto improvement of all stakeholders. This paper was accepted by Jayashankar Swaminathan, operations management. Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2021.03658 .
Linear Lexicographic Optimization and Preferential Bidding System
Authors: Tellache Nour ElHouda , Meunier Frédéric , Parmentier Axel 
Published: March 2024

Some airlines use the preferential bidding system to construct the schedules of their pilots. In this system, the pilots bid on the different activities and the schedules that lexicographically maximize the scores of the pilots according to their seniority are selected. A sequential approach to solve this maximization problem is natural: The problem is first solved with the bids of the most senior pilot, and then it is solved with those of the second most senior without decreasing the score of the most senior, and so on. The literature admits that the structure of the problem somehow imposes such an approach. The problem can be modeled as an integer linear lexicographic program. We propose a new efficient method, which relies on column generation for solving its continuous relaxation and returns proven optimality gaps. To design this column generation, we prove that bounded linear lexicographic programs admit “primal-dual” feasible bases, and we show how to compute such bases efficiently. Another contribution on which our method relies is the extension of standard tools for resource-constrained longest path problems to their lexicographic versions. This is useful in our context because the generation of new columns is modeled as a lexicographic resource-constrained longest path problem. Numerical experiments show that this new method is already able to solve to proven optimality industrial instances provided by Air France, with up to 150 pilots. By adding a last ingredient in the resolution of the longest path problems, which exploits the specificity of the preferential bidding system, the method achieves for these instances computational times that are compatible with operational constraints. Supplemental Material: The online appendix is available at https://doi.org/10.1287/trsc.2022.0372 .
Association of daytime napping with incidence of chronic kidney disease and end-stage kidney disease: A prospective observational study
Authors: Li Qinjun , Shan Ying , Liao Jingchi , Wang Ling , Wei Yanling , Dai Liang , Kan Sen , Shi Jianqing , Huang Xiaoyan , Lu Guoyuan 
Published: March 2024

Background and aims
Few studies have examined the relationship between daytime napping and risk of kidney diseases. We aimed to investigate the association of daytime napping with the incidence of chronic kidney disease (CKD) and end-stage kidney disease (ESKD). We also examined whether sleep duration modified the association of nap with CKD or ESKD.

Methods
We recruited 460,571 European middle- to older-aged adults without prior CKD or ESKD between March 13, 2006, and October 1, 2010, in the UK Biobank. Sleep behavior data were obtained through questionnaires administered during recruitment. The analysis of the relationship between napping and the occurrence of CKD and ESKD utilized Cox proportional hazards regression models. The modification role of sleep duration on the effect of nap on CKD and ESKD was also examined.

Results
After a mean follow-up of 11.1 (standard deviation 2.2) years, we observed 28,330 incident CKD cases and 927 ESKD cases. The daytime napping was associated with incident CKD (P for trend = .004). After fully adjusted, when compared with participants who did not take nap, those in sometimes and usually nap groups had higher risk of CKD. Nevertheless, the available evidence did not support a link between daytime napping and ESKD (P for trend = .06). Simultaneously, there was insufficient evidence suggesting that sleeping duration modified the association of daytime napping with incident CKD or ESKD.

Conclusion
Daytime napping was associated with an increased risk of CKD. However, the absence of conclusive evidence did not indicate a connection between daytime napping and ESKD.