bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inhibition of toll‐like receptor 4 breaks the inflammatory loop in autoimmune destructive arthritis
Authors: Abdollahi‐Roodsaz Shahla , Joosten Leo A. B. , Roelofs Mieke F. , Radstake Timothy R. D. J. , Matera Giovanni , Popa Calin , van der Meer Jos W. M. , Netea Mihai G. , van den Berg Wim B. 
Published: August 2007

AbstractObjectiveDegeneration of extracellular matrix of cartilage leads to the production of molecules capable of activating the immune system via Toll‐like receptor 4 (TLR‐4). The objective of this study was to investigate the involvement of TLR‐4 activation in the development and progression of autoimmune destructive arthritis.MethodsA naturally occurring TLR‐4 antagonist, highly purified lipopolysaccharide (LPS) from Bartonella quintana, was first characterized using mouse macrophages and human dendritic cells (DCs). Mice with collagen‐induced arthritis (CIA) and mice with spontaneous arthritis caused by interleukin‐1 receptor antagonist (IL‐1Ra) gene deficiency were treated with TLR‐4 antagonist. The clinical score for joint inflammation, histologic characteristics of arthritis, and local expression of IL‐1 in joints were evaluated after treatment.ResultsThe TLR‐4 antagonist inhibited DC maturation induced by Escherichia coli LPS and cytokine production induced by both exogenous and endogenous TLR‐4 ligands, while having no effect on these parameters by itself. Treatment of CIA using TLR‐4 antagonist substantially suppressed both clinical and histologic characteristics of arthritis without influencing the adaptive anti–type II collagen immunity crucial for this model. Treatment with TLR‐4 antagonist strongly reduced IL‐1β expression in articular chondrocytes and synovial tissue. Furthermore, such treatment inhibited IL‐1–mediated autoimmune arthritis in IL‐1Ra−/− mice and protected the mice against cartilage and bone pathology.ConclusionIn the present study, we demonstrate for the first time that inhibition of TLR‐4 suppresses the severity of experimental arthritis and results in lower IL‐1 expression in arthritic joints. Our data suggest that TLR‐4 might be a novel target in the treatment of rheumatoid arthritis.
Varus foot alignment and hip conditions in older adults
Authors: Gross K. Douglas , Niu Jingbo , Zhang Yu Qing , Felson David T. , McLennan Christine , Hannan Marian T. , Holt Kenneth G. , Hunter David J. 
Published: August 2007

AbstractObjectiveMechanical strain on the hip can result from varus malalignment of the foot. This study was undertaken to explore the cross‐sectional relationship between varus foot alignment and hip conditions in a population of older adults.MethodsThe Framingham Osteoarthritis Study cohort consists of a population‐based sample of older adults. Within this sample, we measured forefoot and rearfoot frontal plane alignment using photographs of a non–weight‐bearing view of both feet of 385 men and women (mean age 63.1 years). Each foot segment was categorized according to the distribution of forefoot and rearfoot alignment among cases of ipsilateral hip pain, trochanter tenderness, hip pain or tenderness, and total hip replacement (THR). The relationship of foot alignment to these conditions was examined using logistic regression and generalized estimating equations, adjusting for age, body mass index, sex, and physical activity.ResultsThe mean ± SD rearfoot varus alignment was 0.7 ± 5.5 degrees, and the mean ± SD forefoot varus alignment was 9.9 ± 9.9 degrees. Subjects in the highest category of forefoot varus alignment had 1.8 times the odds of having ipsilateral hip pain (P for trend = 0.06), 1.9 times the odds of having hip pain or tenderness (P for trend < 0.01), and 5.1 times the odds of having undergone THR (P for trend = 0.04) compared with those in the lowest category. No significant associations were found between rearfoot varus alignment and any hip conditions.ConclusionForefoot varus malalignment may be associated with ipsilateral hip pain or tenderness and THR in older adults. These findings have implications for treatment, since this risk factor is potentially modifiable with foot orthoses.
Circulating C3 is necessary and sufficient for induction of autoantibody‐mediated arthritis in a mouse model
Authors: Monach Paul A. , Verschoor Admar , Jacobs Jonathan P. , Carroll Michael C. , Wagers Amy J. , Benoist Christophe , Mathis Diane 
Published: August 2007

AbstractObjectiveFor the inflammation characteristic of rheumatoid arthritis, the relative contribution of mediators produced locally in the synovium versus those circulating systemically is unknown. Complement factor C3 is made in rheumatoid synovium and has been proposed to be a crucial driver of inflammation. The aim of this study was to test, in a mouse model of rheumatoid arthritis, whether C3 synthesized within the synovium is important in promoting inflammation.MethodsRadiation bone marrow chimeras between normal and C3−/− mice were constructed in order to generate animals that expressed or lacked expression of C3 only in hematopoietic cells. Parabiotic mice were made by surgically linking C3−/− mice to irradiated wild‐type mice to obtain animals having C3 only in the circulation. Arthritis was induced by injection of serum from arthritic K/BxN mice.ResultsIn bone marrow chimeras, synthesis of C3 by radioresistant cells was necessary and sufficient to confer susceptibility to serum‐transferred arthritis. Parabionts having C3 only in the circulation remained sensitive to arthritis induction, and the cartilage of these arthritic mice contained deposits of C3.ConclusionIn a mouse model in which the alternative pathway of complement activation is critical to the induction of arthritis by autoantibodies, circulating C3 was necessary and sufficient for arthritis induction.
Identification of a novel autoantibody directed against small ubiquitin‐like modifier activating enzyme in dermatomyositis
Authors: Betteridge Zoë , Gunawardena Harsha , North Jean , Slinn Jenna , McHugh Neil 
Published: August 2007

AbstractObjectiveMyositis‐specific autoantibodies (MSAs) are directed against cell machinery proteins such as aminoacyl–transfer RNA synthetases, signal recognition particle, Mi‐2, and CADM‐140. Because serologic subsets can define patients with specific clinical manifestations, the identification of further MSAs may help to identify additional disease subsets within the myositis spectrum.MethodsSera from 20 adult patients with dermatomyositis (DM) were screened for autoantibodies. Two patients were further characterized due to the presence of the same novel immunoprecipitation (IP) pattern on sodium docecyl sulfate–polyacrylamide gel electrophoresis (SDS‐PAGE) and similar clinical manifestations. Both patients presented with cutaneous disease, followed by proximal myositis 6 months later. Both patients had associated nonspecific interstitial pneumonia but no signs of malignancy. The novel targets were identified using a combination of IP, SDS‐PAGE, and matrix‐assisted laser desorption ionization–time‐of‐flight mass spectrometry.ResultsIndirect HEp‐2 immunofluorescence on sera from both patients displayed a diffuse, coarse, speckled, nucleolar‐sparing pattern. IP revealed the presence of previously uncharacterized bands at ∼40 kd and ∼90 kd in both patients. The novel targets were identified as the small ubiquitin‐like modifier 1 (SUMO‐1) activating enzyme A subunit and SUMO‐1 activating enzyme B subunit.ConclusionThese findings reveal previously uncharacterized autoantibodies directed against a protein involved in posttranslational modification, the SUMO activating enzyme, in 2 patients with DM who had similar clinical features, including severe skin disease and interstitial pneumonia.
A Theoretical Study of the Structure and Thermochemical Properties of Alkali Metal Fluoroplumbates MPbF3
Authors: Boltalin A. I. , Korenev Yu. M. , Sipachev V. A. 
Published: August 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Calculated Electronic Structure and Measured X‐Ray Photoemission Spectrum of UAuSb2.
Authors: Morkowski J. A. , Szajek A. , Talik E. , Troc R. 
Published: August 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synchrotron X‐Ray Study of Noncentrosymmetric Tb3RuO7 with Partial Structural Disorder.
Authors: Ishizawa Nobuo , Suwa Tsuyoshi , Tateishi Kenji , Hester James R. 
Published: August 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Na6(H2O)20 (V10O28)×4H2O, a Novel Polyvanadate(V) with a Three‐Dimensional Framework.
Authors: Guo Hong‐Xu , Yao Zhong‐Liang 
Published: August 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Different Cation Arrangements in Au—In Networks. Syntheses and Structures of Six Intermetallic Compounds in Alkali‐Metal—Au—In Systems.
Authors: Li Bin , Corbett John D. 
Published: August 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Formation and Characterization of the Tetranuclear Scandium Nitride: Sc4N4.
Authors: Gong Yu , Zhao YanYing , Zhou Mingfei 
Published: August 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Interconvertible Side‐On‐ and End‐On‐Bonded Oxo—Superoxo Titanium Ozonide Complexes.
Authors: Gong Yu , Zhou Mingfei , Tian Shan Xi , Yang Jinlong 
Published: August 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Polyoxomolybdenum(V)/(VI)—Sulfite Compounds: Synthesis, Structural and Physical Studies.
Authors: Kapakoglou Nikolaos I. , Panagiotis Betzios I. , Kazianis Spiros E. , Kosmidis Constantine E. , Drouza Chryssoula , Manos Manolis J. , Sigalas Michael P. , Keramidas Anastasios D. , Kabanos Themistoklis A. 
Published: August 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Novel Intermetallic Compound UFe5Si3: A New Room‐Temperature Magnet with an Original Atomic Arrangement.
Authors: Berthebaud David , Goncalves Antonio P. , Tougait Olivier , Potel Michel , Lopes Elsa B. , Noel Henri 
Published: August 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Scandium‐Catalyzed Ring‐Opening Desymmetrization of meso‐Epoxides.
Authors: Ogawa Chikako , Wang Naiwei , Boudou Marine , Azoulay Stephane , Manabe Kei , Kobayashi Shu 
Published: August 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of Multisubstituted Furans, Pyrroles, and Thiophenes via Ynolates.
Authors: Shindo Mitsuru , Yoshimura Yutaka , Hayashi Maiko , Soejima Hiroe , Yoshikawa Takashi , Matsumoto Kenji , Shishido Kozo 
Published: August 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Reactions with Dimethylformamide‐Dimethylacetal: Synthesis and Reactions of Several New Pyridine and Pyrazolo[3,4‐b]pyridine Derivatives.
Authors: Elneairy Mohamed A. A. , Gad‐Elkareem Mohamed A. M. , Taha Adel M. 
Published: August 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Reactions with 3,6‐Diaminothieno[2,3‐b]pyridines: Synthesis and Characterization of Several New Fused Pyridine Heterocycles.
Authors: Gad‐Elkareem Mohamed A. M. , Elneairy Mohamed A. A. , Taha Adel M. 
Published: August 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Enhancement of Cyclopropanation Chemistry in the Silver‐Catalyzed Reactions of Aryldiazoacetates.
Authors: Thompson Janelle L. , Davies Huw M. L. 
Published: August 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Selective Oxidation of Benzyl Alcohol to Benzaldehyde with Hydrogen Peroxide over Tetra‐alkylpyridinium Octamolybdate Catalysts.
Authors: Guo Ming‐Lin , Li Hui‐Zhen 
Published: August 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Intramolecular Carbolithiation of 2,6‐Dilithio‐1,6‐heptadienes: An Experimental and Theoretical Study.
Authors: Sanz Roberto , Ignacio Jose M. , Rodriguez Miguel A. , Fananas Francisco J. , Barluenga Jose 
Published: August 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Phosphaalkenes Palladium(II) Complexes in the Suzuki and Sonogashira Cross‐Coupling Reactions.
Authors: Deschamps Bernard , Le Goff Xavier , Ricard Louis , Le Floch Pascal 
Published: August 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Mild and Efficient Pentafluorophenylammonium Triflate (PFPAT)‐Catalyzed C‐Acylations of Enol Silyl Ethers or Ketene Silyl (Thio)Acetals with Acid Chlorides.
Authors: Iida Akira , Osada Jun , Nagase Ryohei , Misaki Tomonori , Tanabe Yoo 
Published: August 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Broensted Acid Catalyzed Benzylation of 1,3‐Dicarbonyl Derivatives.
Authors: Sanz Roberto , Miguel Delia , Martinez Alberto , Alvarez‐Gutierrez Julia M. , Rodriguez Felix 
Published: August 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Practical Approach for Hydroheteroarylation of Alkynes Using Bench‐Stable Catalyst.
Authors: Kanyiva Kyalo Stephen , Nakao Yoshiaki , Hiyama Tamejiro 
Published: August 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Highly Regioselective Hydroformylation of Higher Olefins Catalyzed by Rhodium‐Phosphine Complexes in Ionic Liquid Medium.
Authors: Lin Qi , Fu Haiyan , Jiang Weidong , Chen Hua , Li Xianjun 
Published: August 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Alkyl‐ and Arylation of Oxacyclic Ethers with Triethylsilyl Triflate — 2,4,6‐Collidine — Gilman Reagent Combination: Remarkable Discrimination of Two Ether Oxygens.
Authors: Fujioka Hiromichi , Ohnaka Takuya , Okitsu Takashi , Kubo Ozora , Okamoto Kazuhisa , Sawama Yoshinari , Kita Yasuyuki 
Published: August 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Iron‐Catalyzed Alkylations of Aromatic Grignard Reagents.
Authors: Cahiez Gerard , Habiak Vanessa , Duplais Christophe , Moyeux Alban 
Published: August 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Cationic Vanadium(IV) Complexes as Efficient Catalysts for Nazarov Cyclizations.
Authors: Walz Irene , Bertogg Andreas , Togni Antonio 
Published: August 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Highly Enantioselective and Catalytic Aryl Transfer Reaction Using Mixed Triarylbismuthane and Dialkylzinc Reagents.
Authors: Sato Itaru , Toyota Yousuke , Asakura Noriaki 
Published: August 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Storable, Powdered Chiral Zirconium Complex for Asymmetric Aldol and Hetero Diels—Alder Reactions.
Authors: Seki Kazutaka , Ueno Masaharu , Kobayashi Shu 
Published: August 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Preparation and Condensation Reactions of a New Light‐Fluorous Mukaiyama Reagent: Reliable Purification with Fluorous Solid Phase Extraction for Esters and Amides.
Authors: Matsugi Masato , Hasegawa Masakazu , Sadachika Daisuke , Okamoto Sachina , Tomioka Mami , Ikeya Yoshimi , Masuyama Araki , Mori Yuji 
Published: August 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
ortho Arylation of Acetanilides via Pd(II)‐Catalyzed C—H Functionalization.
Authors: Yang Shangdong , Li Bijie , Wan Xiaobing , Shi Zhangjie 
Published: August 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Ruthenium‐Catalyzed Carbon—Carbon Bond Formation via the Cleavage of an Unreactive Aryl Carbon—Nitrogen Bond in Aniline Derivatives with Organoboronates.
Authors: Ueno Satoshi , Chatani Naoto , Kakiuchi Fumitoshi 
Published: August 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Reduction Dearomatization of Biphenyl: Sequential One‐Pot Regioselective Introduction of Two Different Electrophiles.
Authors: Melero Cristobal , Perez Henoc , Guijarro Albert , Yus Miguel 
Published: August 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Microwave‐Assisted Copper‐Catalyzed Sonogashira Reaction in PEG Solvent.
Authors: Colacino Evelina , Daich Latifa , Martinez Jean , Lamaty Frederic 
Published: August 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
One‐Pot Synthesis of 1,4‐Naphthoquinones and Related Structures with Laccase.
Authors: Witayakran Suteera , Ragauskas Arthur J. 
Published: August 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Catalytic Diastereo‐ and Positionselective Oxidative Monocyclization of 1,5,9‐Trienes and Polyenes.
Authors: Goehler Sabrina , Stark Christian B. W. 
Published: August 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Triflic Acid Controlled Successive Anellation of Aromatic Sulfonamides: An Efficient One‐Pot Synthesis of N‐Sulfonyl Pyrroles, Indoles and Carbazoles.
Authors: Abid Mohammed , Teixeira Liliana , Toeroek Bela 
Published: August 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of Polysubstituted Pyrroles Starting from the Baylis—Hillman Adducts.
Authors: Lee Hyun Seung , Kim Jeong Mi , Kim Jae Nyoung 
Published: August 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of Bis(indolyl)methanes Catalyzed by Acidic Ionic Liquid Immobilized on Silica (ILIS).
Authors: Hagiwara Hisahiro , Sekifuji Masayoshi , Hoshi Takashi , Qiao Kun , Yokoyama Chiaki 
Published: August 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of Aryl Conjugated (1‐Azaazulenyl)acetylenes and Facile Synthesis of Thiophene Fused 1‐Azaazulenes.
Authors: Abe Noritaka , Harada Yohei , Imachi Yukiko , Fujii Hiroyuki , Kakehi Akikazu , Shiro Motoo 
Published: August 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Efficient Synthesis of 7‐Substituted or 3,7‐Disubstituted 1H‐Indazoles
Authors: Cottyn Betty Cottyn Betty , Vichard Dominique , Terrier Francois , Nioche Pierre , Raman C. S. 
Published: August 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
An Efficient and Green Procedure for the Preparation of 2‐{2‐[N′‐(2‐Hydroxybenzylidene)hydrazino]‐thiazol‐4‐yl}phenols.
Authors: Kamble Vinod T. , Davane Bhaskar S. , Chavan Sanjay A. , Bhosale Raghunath B. 
Published: August 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of Substituted 1,2,4‐Oxadiazoles from Substituted Acid Chlorides and Amidoximes under Mild Conditions.
Authors: Bora Rajesh O. , Farooqui Mazahar 
Published: August 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.