bluuebunny/crossref_metadata_2025_split huggingface dataset:
ОНОВЛЕНІ УЗАГАЛЬНЕНІ РЕКОМЕНДАЦІЇ З ЛІКУВАННЯ ГЕРПЕСВІРУСНИХ ІНФЕКЦІЙ ЛЮДИНИ
Authors: Maltsev Dmytro 
Published: February 2024

Мета роботи. Провести систематизацію наукових доказів ефективності застосування різних лікувальних засобів при герпесвірусних інфекціях людини в клінічній практиці. Матеріали та методи. Представлені рекомендації є оновленням відповідного документу 2012 року щодо лікування герпесвірусних інфекцій з врахуванням нових наукових доказів, накопичених протягом останнього десятиліття і опублікованих у рецензованих періодичних медичних виданнях, що втдозмінюють підходи до лікування герпесвірусних інфекцій. Здійснено аналітичний огляд наукових публікацій, присвячених вивченню класифікації, клінічних проявів та різних аналогів нуклеозидів, аденіну арабінозиду, артесунату та імунотерапевтичних інтервенцій для лікування або профілактики герпесвірусних інфекцій. Результати і обговорення. Приймаючи до уваги пантропізм герпесвірусних збудників і здатність до індукції мультиорганних уражень із залученням різних патогенетичних шляхів, медичні фахівці всіх спеціальностей повинні бути належним чином поінформовані з проблеми герпесвірусних інфекцій та, відповідно, вміти своєчасно виявляти, лікувати та попереджати різні форми герпетичних інфекцій. На відміну від збудників ГРВІ і багатьох інших вірусних агентів, здатних інфікувати Homo sapiens, герпесвіруси мають складну адаптивну програму паразитування в організмі людини, що передбачає тонке реципрокне маневрування збудника під час реалізації репродуктивного потенціалу у відповідь на тиск з боку імунного нагляду організму хазяїна з метою ухилення від імунної відповіді. Основу сучасної противірусної терапії при герпесвірусних інфекціях складають ациклічні аналоги нуклеозидів як специфічні віростатичні протигерпетичні хіміопрепарати, основнимй механізм дії яких полягає у вибірковій блокаді елонгації вірусної ДНК під час реплікації (табл. 2). Ацикловір ефективний здебільшого при інфекціях, викликаних альфагерпесвірусами, однак не бета- і гамма-герпесвірусами, коли використовують переважно ганцикловір, фоскарнет та цидофовір. Розрізняють епізодичну і супресивну терапію герпесвірусних інфекцій противірусними хіміопрепаратами. Епізодичну терапію призначається у разі первинної інфекції та при поодиноких важких епізодах реактивації латентного або персистуючого герпесвірусу в гостру фазу патологічного процесу. Супресивна терапія може включати індукційну і підтримувальну фазу або складатися тільки з підтримувальної фази залежно від важкості інфекційного ураження. Рекомендації, засновані на наукових доказах, створенні для регламентування, стратифікації та оптимізації надання медичної допомоги пацієнтам з герпесвірусною інфекцією. Висновки. Розглянута доказова база різних аналогів нуклеозидів, аденіну арабінозиду, артесунату та різноманітних імунотерапевтичних інтервенцій, призначених з метою лікування або профілактики герпесвірусних інфекцій. Підкреслено мультидисциплінарність та персонірусними ураженнями. Дані рекомендації будуть корисними для лікарів різних спеціальностей з огляду на безпрецедентний пантропізм герпесвірусних агентів людини.
Metadherin promotes stem cell phenotypes and correlated with immune infiltration in hepatocellular carcinoma
Authors: Wang Yi-Ying , Shen Mei-Mei , Gao Jian 
Published: February 2024

BACKGROUND
Metadherin (MTDH ) is a key oncogene in most cancer types, including hepatocellular carcinoma (HCC). Notably, MTDH does not affect the stemness pheno-type or immune infiltration of HCC.
AIM
To explore the role of MTDH on stemness and immune infiltration in HCC.
METHODS
MTDH expression in HCC tissues was detected using TCGA and GEO databases. Immunohistochemistry was used to analyze the tissue samples. MTDH was stably knocked down or overexpressed by lentiviral transfection in the two HCC cell lines. The invasion and migration abilities of HCC cells were evaluated using Matrigel invasion and wound healing assays. Next, we obtained liver cancer stem cells from the spheroids by culturing them in a serum-free medium. Gene expression was determined by western blotting and quantitative reverse tran-scription PCR. Flow cytometry, immunofluorescence, and tumor sphere formation assays were used to characterize stem-like cells. The effects of MTDH inhibition on tumor growth were evaluated in vivo . The correlation of MTDH with immune cells, immunomodulators, and chemokines was analyzed using ssGSEA and TISIDB databases.
RESULTS
HCC tissues expressed higher levels of MTDH than normal liver tissues. High MTDH expression was associated with a poor prognosis. HCC cells overexpressing MTDH exhibited stronger invasion and migration abilities, exhibited a stem cell-like phenotype, and formed spheres; however, MTDH inhibition attenuated these effects. MTDH inhibition suppressed HCC progression and CD133 expression in vivo . MTDH was positively correlated with immature dendritic, T helper 2 cells, central memory CD8+ T, memory B, activated dendritic, natural killer (NK) T, NK, activated CD4+ T, and central memory CD4+ T cells. MTDH was negatively correlated with activated CD8+ T cells, eosinophils, activated B cells, monocytes, macrophages, and mast cells. A positive correlation was observed between the MTDH level and CXCL2 expression, whereas a negative correlation was observed between the MTDH level and CX3CL1 and CXCL12 expression.
CONCLUSION
High levels of MTDH expression in patients with HCC are associated with poor prognosis, promoting tumor stemness, immune infiltration, and HCC progression.
Practice effects on dual-task order coordination and its sequential adjustment
Authors: Strobach Tilo 
Published: February 2024

AbstractWhen the performance of two tasks overlaps in time, performance impairments in one or both tasks are common. Various theoretical explanations for how component tasks are controlled in dual-task situations have been advanced. However, less attention has been paid to the issue of how two temporally overlapping tasks are appropriately coordinated in terms of their order. The current study focuses on two specific aspects of this task-order coordination: (1) the potential effects of practice on task-order coordination performance and (2) its relationships with cognitive meta-control mechanisms that adjust this coordination. These aspects were investigated in a visual-auditory dual-task combination with randomly changing task orders across trials after four sessions of dual-task practice (N = 24) and single-task practice (N = 24). The results demonstrated that task-order coordination improves during dual-task practice, and in contrast to the effects of single-task practice. Practice, on the other hand, did not show substantial evidence of an effect on the adjustment of task-order coordination. This practice-related dissociation is consistent with the assumption that (1) task-order coordination and (2) its sequential adjustment are separable sets of processes.
Anestezide Hasta Güvenliği
Authors: Aykaç Z. Zuhal , Sizer Çiğdem , Kara İnci , Çolakoğlu Serhan , Arça Dilek Ömür , Erkalp Kerem , Akın Mine , Köner Özge , Atalan Nazan , Keskin Gülsen , Pişkin Özcan , Aşkın Tuğba , Küçükosman Gamze , Bilgin Hülya , Özgök Ayşegül , Aydın Bengü Gülhan , Hancı Volkan , Gürsoy Çirkinoğlu Gözde , Ayoğlu Hilal , Gönüllü Edip , Çalışkan Taner , Boztaş Nilay , Arslan Yurtlu Derya , Ürkmez Seval , Edipoğlu İpek , Saraçoğlu Kemal Tolga , Özer Yetkin , Yağar Seyhan , Şenaylı Yeşim , Saraçoğlu Ayten , Edipoğlu İpek , Özer Yetkin , Ayoğlu Hilal , Şenaylı Yeşim , Saraçoğlu Ayten , Özgök Ayşegül , Yağar Seyhan , Yılmazlar Aysun 
Published: February 2024

Hasta Güvenliği: Neden Biz? Ne Durumdayız?
Tuğhan UTKU
Anestezide Hasta Güvenliği Dünden Bugüne
Zuhal AYKAÇ
Güvenlik Kültürü Nasıl Geliştirilir?
Çiğdem SİZER, İnci KARA
Hasta Güvenliğini Tehdit Edenlerden/Hatalardan Öğrenimler
Serhan ÇOLAKOĞLU
Hata ve Zararın Nitelik ve Ölçekleri
Çiğdem SİZER, İnci KARA
Hata Bildirim Sistemleri-Raporlama ve Öğrenme Sistemleri
Dilek ÖMÜR
Güvenlik Değerlendirme Kalite-Ölçüm Stratejileri
Kerem ERKALP
Güvenli Kuruluşlar
Mine AKIN
Sağlık Politikaları ve Hasta Güvenliği
Özge KÖNER
Hasta Güvenliğinde Teknik Olmayan Beceriler
Nazan ATALAN
Ameliyat Öncesi Teşhis Hataları - Preoperatif Değerlendirme Hataları ve Güvenlik
Gülsen KESKİN
Ameliyathanelerde Güvenlik
Özcan PİŞKİN
Anestezi Makine ve Ekipman Kullanımında Güvenlik
Tuğba AŞKIN
Hastaların Ameliyathaneye Transferleri ve Güvenlik
Gamze KÜÇÜKOSMAN
İntraoperatif Hatalar ve Güvenlik
Özge KÖNER
Termoregülasyon ve Perioperatif İstemsiz Hipotermi
Hülya BİLGİN
İlaç Hataları
Ayşegül ÖZGÖK
Rejyonal Anestezide Hasta Güvenliği
Bengü AYDIN
Anestezik Farmakolojide Hasta Güvenliği
Volkan HANCI, Gözde GÜRSOY ÇİRKİNOĞLU
Postoperatif Hatalar ve Güvenlik
Hilal AYOĞLU
Postoperatif Ağrı Kontrolünde ve Ağrı Tedavisinde Hasta Güvenliği
Edip GÖNÜLLÜ
Yoğun bakımda hasta güvenliği
Volkan HANCI, Taner ÇALIŞKAN
Hasta Transferleri ve Güvenlik
Nilay BOZTAŞ
Ameliyathane Dışı ve Günübirlik Anestezi Uygulamalarında Güvenlik
Derya ARSLAN YURTLU
Düşmeleri Önleme
Bengü Gülhan AYDIN
Bası Ülserlerini Önleme
Bengü Gülhan AYDIN
Deliryumu Önleme
Nazan ATALAN
Derin Ven Trombozu Proflaksisi
Seval ÜRKMEZ, Tuğhan UTKU
Zor / Başarısız Havayolu Hastanın Preoperatif Değerlendirilmesi ve Planlanması
İpek EDİPOĞLU
Anafilaksi
Tolga SARAÇOĞLU
Lokal Anestezik Toksisitesi
Tolga SARAÇOĞLU
Enfeksiyon Kontrolü
Yetkin ÖZER
Kayıtlarda ve Orderlarda Güvenlik ve Gizlilik
Seyhan YAĞAR
Pediatrik Hastalarda Güvenlik
Yeşim ŞENAYLI
Geriatrik Hastalarda Güvenlik
Ayten SARAÇOĞLU
Obstetrik Hastalarda Güvenlik
İpek EDİPOĞLU
Teknoloji ve Standardizasyon Tasarımı (Güvenlik Riskleri)
Yetkin ÖZER
Çevresel Etmenler ve Güvenlik
Hilal AYOĞLU
Eğitim ve Öğretim
Yeşim ŞENAYLI
Hasta Güvenliğinde Simülasyon Eğitimi ve Kriz Kaynak Yönetiminde Simülasyon
Ayten SARAÇOĞLU
Uzmanlık Öğrencisi Eğitiminde Hasta Güvenliği
Ayşegül ÖZGÖK
Klinik Araştırmalarda Katılımcıların (Hastaların, Sağlıklı Bireylerin) Güvenliğinin Sağlanması
Seyhan YAĞAR
Akreditasyon ve Düzenlemeler
Aysun YILMAZLAR
Hasta Güvenliğinde Yalın Uygulamalar
Aysun YILMAZLAR
Harp Cerrahisi Perspektifleri Muharebe Sahasında Yaralılara Güncel Tıbbi Yaklaşımlar (Rol 1)
Authors: Özmen Pelin , Hançerlioğulları Oğuz , Kaymak Şahin , Güven Hikmet Erhan , Şenocak Rahman , Artuk Cumhur , Yılmaz Soner , Yaşar Soner , Öksüz Sinan , Şahin İsmail , Özge Gökhan , Sapmaz Ersin , Işık Hakan , Karabacak Kubilay , Erol Gökhan , Uluçay Çağatay , Ege Tolga , Durmaz Mehmet Ozan , Bedir Selahattin , Lapsekili Emin , Sezigen Sermet , Sir Ender , İnce Mehmet Emin , Karasimav Özlem , Özsoy Sait , Tanrıseven Mustafa 
Published: February 2024

Harp Travma Sistemleri
Pelin ÖZMEN
Harp Yaralanmalarında Tıbbi Bakım Rolleri
Pelin ÖZMEN
Travma Kinematiği, Yara Balistiği ve Patlayıcılar
Aytekin ÜNLÜ
Muharebe Sahasında Harp Yaralanmalarına Yaklaşım
Oğuz HANÇERLİOĞULLARI, Şahin KAYMAK
Kitlesel Harp Yaralanmaları ve Triyaj
Burak AŞIK
Tıbbi veri Aktarımı, Verilerin Kaydedilmesi ve Ders Alınması (Bilgi⇒Analiz⇒Gelişme)
Hikmet Erhan GÜVEN
Helikopterle Yaralı Tahliyesi
Burak AŞIK
Hava Yolu Yönetimi
Sami EKSERT
Kardiyopulmoner Resusitasyon
Sami EKSERT
Travma ve Hemorajik Şok
Aytekin ÜNLÜ
Kanama Kontrolü ve Turnike Uygulaması
Şahin KAYMAK
Kanama Durdurucular
Rahman Şenocak
Harp Yaralanmalarına Bağlı Enfeksiyonlar ve Akılcı Antibiyotik Kullanımı
Cumhur ARTUK
Kan Hizmet Birimleri için Standartlar
Soner YILMAZ
Alternatif Kan Ürünleri ve Sahrada Kanın Klinik Kullanımı
Soner YILMAZ
Kafanın Ateşli Silah Yaralanmaları
Soner YAŞAR
Maksillofasiyal Yaralanmalar
Sinan ÖKSÜZ
Yanıklar
İsmail ŞAHİN
Göz Yaralanmaları
Gökhan ÖZGE
Boyun Yaralanmaları
Burak AŞIK
Major Toraks Yaralanmaları
Ersin SAPMAZ
Tup Torakostomi
Hakan IŞIK
Kalp Yaralanmaları
Kubilay KARABACAK
Damar yaralanmaları
Gökhan EROL
Kas İskelet Yaralanmaları
Çağatay ULUÇAY
Kompartman Sendromu
Tolga EGE
Spinal Ateşli Silah Yaralanmaları
Mehmet Ozan DURMAZ
Urogenital Travmalar
Rahman ŞENOCAK, Selahattin BEDİR
Muharebe Sahasında Yumuşak Doku Yaralanmaları, Vücutta Kalan Yabancı Cisimlerin Cıkarılması Endikasyonları
Emin LAPSEKİLİ
Tıbbi KBRN Savunması
Sermet SEZİGEN
KBRN Yaralılarının Tıbbi Yönetimi
Sermet SEZİGEN
Ağrı Yonetimi
Ender SİR
Muharebe Sahasında Damar Yolu Seçimi
Mehmet Emin İNCE, Ender SİR
Hipotermi, Hipertermi ve Yıldırım Çarpmaları
Mustafa TANRISEVEN
Soğuk Isırığı ve Siper Ayağı
Mustafa TANRISEVEN
Muharebe Sahasında Guvenlik Personelinin Sıvı-Elektrolit Dengesinin Korunması (Homeostazis)
Mehmet Emin İNCE
Aklimatizasyon
Özlem KARASİMAV
Yaralanmalar ve Balistik Korunma Kulturunun Geliştirilmesinin Önemi
Şahin KAYMAK
Ulusal ve Uluslararası Hasta ve Sağlık Calışanlarının Hakları ve Sorumlulukları
Sait OZSOY
Detecting Anomalous Images in Astronomical Datasets
Authors: Alonso Pedro , Zhang Jun , Li Xiao-Dong 
Published: February 2024

Abstract
Environmental and instrumental conditions can cause anomalies in astronomical images, which can potentially bias all kinds of measurements if not excluded. Detection of the anomalous images is usually done by human eyes, which is slow and sometimes not accurate. This is an important issue in weak lensing studies, particularly in the era of large-scale galaxy surveys, in which image qualities are crucial for the success of galaxy shape measurements. In this work we present two automatic methods for detecting anomalous images in astronomical data sets. The anomalous features can be divided into two types: one is associated with the source images, and the other appears on the background. Our first method, called the entropy method, utilizes the randomness of the orientation distribution of the source shapes and the background gradients to quantify the likelihood of an exposure being anomalous. Our second method involves training a neural network (autoencoder) to detect anomalies. We evaluate the effectiveness of the entropy method on the Canada–France–Hawaii Telescope Lensing Survey (CFHTLenS) and Dark Energy Camera Legacy Survey (DECaLS DR3) data. In CFHTLenS, with 1171 exposures, the entropy method outperforms human inspection by detecting 12 of the 13 anomalous exposures found during human inspection and uncovering 10 new ones. In DECaLS DR3, with 17112 exposures, the entropy method detects a significant number of anomalous exposures while keeping a low false-positive rate. We find that although the neural network performs relatively well in detecting source anomalies, its current performance is not as good as the entropy method.
He-rich Hot Subdwarf Stars Observed in Gaia DR3 and LAMOST DR7: Carbon and Nitrogen Abundances and Kinematics
Authors: Luo Yangping , Németh Péter , Wang Kun , Pan Yang 
Published: February 2024

Abstract
We conducted an analysis of the abundances of He, C, and N in 210 He-rich hot subdwarfs observed within both the Gaia Data Release 3 (DR3) and LAMOST DR7 data sets. This analysis involved fitting the LAMOST spectra with Tlusty/Synspec non-LTE synthetic spectra. By examining the Galactic spatial positions, velocity vectors, and orbital parameters of these stars, we determined their Galactic population memberships utilizing LAMOST radial velocities and Gaia DR3 parallaxes along with proper motions. Our investigation revealed two positive correlations of C and one positive correlation of N with respect to the He abundance. We found a clear C abundance dichotomy where approximately 82% of the stars show N enrichment above the solar value. Moreover, we observed a bimodal distribution of C abundances, prominently evident in both the Galactic thin and thick disks but absent in the halo population. Furthermore, we found that the scenario of the merger channel of double helium white dwarfs is inadequate to explain the formation of C-deficient He-rich hot subdwarfs.
Discovery of Magnetically Guided Metal Accretion onto a Polluted White Dwarf
Authors: Bagnulo Stefano , Farihi Jay , Landstreet John D. , Folsom Colin P. 
Published: February 2024

Abstract
Dynamically active planetary systems orbit a significant fraction of white dwarf stars. These stars often exhibit surface metals accreted from debris disks, which are detected through infrared excess or transiting structures. However, the full journey of a planetesimal from star-grazing orbit to final dissolution in the host star is poorly understood. Here, we report the discovery that the cool metal-polluted star WD 0816–310 has cannibalized heavy elements from a planetary body similar in size to Vesta, and where accretion and horizontal mixing processes have clearly been controlled by the stellar magnetic field. Our observations unveil periodic and synchronized variations in metal line strength and magnetic field intensity, implying a correlation between the local surface density of metals and the magnetic field structure. Specifically, the data point to a likely persistent concentration of metals near a magnetic pole. These findings demonstrate that magnetic fields may play a fundamental role in the final stages of exoplanetary bodies that are recycled into their white dwarf hosts.
Quality of life in patients with vitiligo in North Macedonia
Authors: Teovska-Mitrevska Natasa 
Published: February 2024

Vitiligo is an acquired depigmentation deficit with a high prevalence, ranging from 0.5% to 7.8%. The aim of the study was to measure the quality of life (QL) of patients with vitiligo, expressed through the Dermatological Quality of Life Index (DLQI). Materials and methods: This cross-sectional study was realized in a period of 1 year. Two questionnaires were used in the study. Тhe first questionnaire contains data from the DLQI, designed for use in adults over 16 years of age, taken from the Cardiff University in the UK. The second questionnaire contains demographic and clinical characteristics of patients (age, gender, place of residence, marital status, education), activity, comorbid diseases and BMI, age at onset, site of onset of lesions, duration of disease, family history, type, activity, natural course, body mass index (BMI) and therapy. Results: Among 71 subjects included in the study, the total score of the DLQI ranged from 0 to 28 (from a maximum of 30 points), and the average was 11.70 ± 5.7. Female patients had greater QL impairment (total mean value of 8.03) than men (5.99); there was a statistically significant difference between both sexes (P = 0.019). The total score of QL in terms of symptoms related to the condition in the six domains strongly affected QL of 45.1% of patients. The QL was significantly worse in the studied group of 16-30 years (13.85 ± 5.3) compared to the population of 51-60 and over 60 years (6.75 ± 5.7, and 7.0 ± 2.3). As the age of patients advanced, the QL improved. Subjects with higher education had a higher score (14.41 ± 6.6; p=0.001). Conclusion: Female patients with vitiligo have impaired QL in comparison to male. With age, the QL in patients with vitiligo improves. Patients with a lower degree of education have a better QL
The Effect of Dextrose Hypotonic vs Saline Hydration on Methotrexate-Induced Nephrotoxicity in Male and Female Rats
Authors: Hasanpour Zahra , Choopani Samira , Ashrafi Farzaneh , Talebi Ardeshir , Nematbaksh Mehdi 
Published: February 2024

Abstract

Background:
High-dose methotrexate (HDMTX) as a cytotoxic agent might cause various side effects. Hyperhydration has been implemented as the major strategy to decrease the potential risk of toxicities induced by HDMTX. This study aims to assess the renoprotective effect of hydration with dextrose water (DW) 5% versus normal saline (N/S) 0.9% against methotrexate (MTX) induced nephrotoxicity.

Materials and Methods:
This experimental animal study has been conducted on 36 Wistar rats (200–250 g) categorized into six groups, including male (n = 6) and female (n = 6) rats receiving sodium chloride 0.9% saline plus MTX, DW 5% plus MTX, or MTX alone. By the fifth day after the MTX injection, biochemical indexes were measured. The rats were also sacrificed and renal specimens were evaluated microscopically to determine kidney tissue damage (KTD).

Results:
The groups were not significantly different with regard to blood urea nitrogen (BUN) (P = 0.5), creatinine (Cr) (P = 0.24), kidney weight (P = 0.34), and urine flow (UF) (P = 0.5), while KTD score was remarkably less in the hydrated groups (P < 0.001). Weight loss in DW-treated rats was significantly more than N/S-treated ones, and creatinine clearance (CrCl) and urine load (UL) of Cr were statistically similar between males and females in the control group, but significantly lower among the DW5% treated males.

Conclusion:
Based on the findings of this study, hydration with N/S was superior to DW5% for the prevention from HDMTX-induced nephrotoxicity. Besides, we found insignificant differences between male versus female rats in response to the hydration for HDMTX-induced renoprotection; however, females probably benefit more.
Toll-Like Receptor 4, 2, and Interleukin 1 Receptor Associated Kinase4: Possible Diagnostic Biomarkers in Myelodysplastic Syndrome Patients
Authors: Khalilian Parvin , Eskandari Nahid , Sharifi Mohammad Jafar , Soltani Mohammad , Nematollahi Pardis 
Published: February 2024

Abstract

Background:
Myelodysplastic syndrome (MDS) is a clonal hematologic disorder that requires the integration of morphologic, cytogenetic, hematologic, and clinical findings for a successful diagnosis. Trying to find ancillary tests such as biomarkers improve the diagnosis process. Several studies showed that a disordered immune system is associated with MDS. The chronic activated innate immune system, particularly the Toll-like receptors (TLRs) pathway could be involved in the induction of the inflammation.

Materials and Methods:
In the present study, we investigated the expression of TLR2, TLR4, and IRAK4 in bone marrow (BM) of MDS patients, the leukemia group, and the healthy group. For this purpose, we assessed the expression of TLR2, TLR4, and IRAK4 by real time-PCR.

Results:
In line with new findings, we demonstrated that the expression of TLR2, TLR4, and IRAK4 significantly increased in MDS BM compared with the healthy group. Moreover, IRAK4 expression raised significantly in MDS patients compared with other studied hematologic neoplasms. Also, the expression levels of TLR2 and TLR4 significantly increased in MDS in comparison to some studied non-MDS malignancies (P ˂ 0.05). Receiver operating characteristics (ROC) analysis and area under the curve (AUC) suggested that the expression of TLR2, TLR4, and IRAK4 (AUC = 0.702, AUC = 0.75, and AUC = 0.682, respectively) had acceptable diagnostic values to identify MDS from the other understudied leukemias.

Conclusion:
Overall, the expression of TLR2, TLR4, and IRAK4 could be potential biomarkers for discriminating MDS from some hematologic disorders.