bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interventions to improve ethical decision-making skills in nursing students: A systematic review
Authors: Kaşıkçı Mağfiret , Yıldırım Zeynep 
Published: April 2024

Background Interventions to improve ethical decision-making are available in nursing education. Evidence of its effectiveness is essential. Objective This review examined the effectiveness of interventions to improve nursing students’ ethical decision-making skills. Methods A structured search was performed in Google Scholar, Web of Science, Science Direct, Pubmed, Scopus, Cochrane Library, Elsevier, CINAHL EBSCO, and ULAKBIM. The Joanna Briggs Institute Meta-Analysis of Statistics Assessment and Review Instruments (JBI-MAStARI) was used to assess the quality of studies. Ethical considerations Ethical approval was not required for this systematic review. Findings The final review was composed of six studies of published between January 2013 and 2023. Nine different teaching methods applied to students. Although the importance of ethical decision-making skills in solving ethical problems that nurses may encounter at any time is known, it is thought that there is a lack of data in the literature in the last 10 years. The last 10 years were chosen as this aims to provide a review based on the most current, relevant and quality information. The review indicated that all of the teaching methods improved ethical decision-making. Conclusion Different teaching methods can be used in the nursing education curriculum to meet the learning needs of nursing students in ethical decision-making.
Multiple Cutaneous Infections Secondary to Inadvertent Use of Systemic Steroids
Authors: Rana Gurveer Singh , Gupta Sharang , Chopra Dimple 
Published: April 2024

Introduction: Steroids have a major role in the treatment of many dermatological disorders. This class of drugs is also one of the most frequently abused drugs, both by patients and doctors. Inadvertent use of steroids can cause a plethora of side effects. Methods: A 43-year-old male who presented to the dermatology outpatient department with complaints of generalized itching and hyperpigmented lesions on his glans was examined clinically. The patient was found to be a known case of pemphigus vulgaris who developed multiple cutaneous infections secondary to the inadvertent use of systemic steroids. Results: The case being presented shows multiple cutaneous infections, a side effect caused by systemic corticosteroids because of the immunosuppression they cause. Conclusion: The present case underscores the need to regulate the dispensing practices of not only corticosteroids but also all the drugs that are sold without the prescription of a registered medical practitioner.
Association of Maternal Height with Mode of Delivery and Perinatal Outcome
Authors: Gummadi Apoorva Anil , Sunkaraneni Sandhya , Kuchana Sai Kiran , Kode Rohith , Riyyan Muhammad 
Published: April 2024

Background: Maternal height has been for long a contributory anthropometric factor that can determine the obstetric outcome. There is always a need of a consistent, reliable, and simple risk indicator which is easy to use for preventing unnecessary complications in a country like India where often antenatal care is provided by dais in rural areas. The background of this research aims to ascertain the relationship between maternal height and mode of delivery based on other intrapartum factors which influence labor and consequent maternal and neonatal outcome. Materials and Methods: All primigravidae at term gestation (>37 weeks) with cephalic presentation on admission to labor suite with no other comorbidities were recruited in the study. Their mode of delivery, maternal outcome, along with neonatal outcome was documented. Results: Out of the 680 patients, 104 patients are considered for the short-stature group (15.29%) who were <150 cm in height. Other group comprised patients who were >150 cm in height, a total of 576 (84.71%). There was a higher incidence of induced labor in the study group (66.35%) and emergency lower-segment cesarean section done due to cephalopelvic disproportion (CPD) (60%) was also higher among the short-stature group. The incidence of normal labor (32.99%) was higher in the tall-stature group. Conclusion: Short height (<150 cm) is an independent risk factor for cesarean delivery due to CPD. Statistical correlation was found between mothers of short stature and babies being born with low birth weight. As labor is influenced by multiple factors, it is fair enough to give a trial of labor for short primigravidae except in uncommon circumstances.
Nurse Practitioner Certification Examination Development: From Reflecting Clinical Practice to Ensuring Lifelong Learning
Authors: Myers Tara , Chappell Kathy , Godwin Cherith , Krissel Jeanna , Ramirez Jeffery , Smith Justin 
Published: April 2024

OBJECTIVE: Certifications in psychiatric-mental health nursing promote safe practice by psychiatric-mental health nurse practitioners (PMHNPs) and nurses (PMHNs) and help protect the public from harm. This protection begins with the development of an examination that meets rigorous national education, practice, and accreditation standards and reflects PMHNPs’ or PMHNs’ clinical practice. Achievement and maintenance of a certification is a journey that involves a commitment to lifelong learning and the improvement of the field of psychiatric-mental health nursing through involvement in the examination process. METHODS: This discussion paper outlines the role nurses can play in the development of certification examinations. It describes the process of developing an effective certification examination, including the role of standards, accrediting bodies, and content experts; determining necessary tasks, knowledge, and skills; surveying practitioners to validate information; writing test questions; and ongoing analysis of examination content. The Psychiatric-Mental Health Nurse Practitioner (across the lifespan) Certification (PMHNP-BC) is presented as an example of the process. RESULTS: This discussion paper raises awareness of how certification exams are developed, PMHNPs participate in certification development, and volunteering promotes career development. CONCLUSION: The PMHNP-BC examination is based on education, practice, and certification accreditation standards and reflects current clinical practice. PMHNPs can (a) point to the rigor of certification as an indication of the quality of care they deliver, (b) volunteer to participate in the examination process to ensure examination rigor, and (c) advance their careers through the development and application of a valuable skill set.
Depictions of social workers and other caring professionals on television
Authors: Leedham Maria 
Published: April 2024

Summary Social workers, alongside many professionals in “caring” domains, often feel they are poorly represented in television dramas. This study draws on a 172-million-word database to consider how social workers and seven other professional groups (cop, doctor, nanny, nurse, priest, teacher, and therapist) are portrayed in English-medium TV programs in the period 2010–2017. IMDb plot summaries are analyzed, and 200 examples per profession (n = 1,600) are classified as negative, positive, or neutral. Employing the methodology of corpus linguistics, the study contrasts with previous research as the focus is on the language surrounding mentions of professionals rather than on visual depictions or characters’ actions. Findings The study evidences the prevalence of negative societal discourses around social workers as either judgmental bureaucrats or uncaring “childcatchers,” contextualizing the findings through comparison with other professionals. The analysis also suggests that social work characters on TV—in common with those from other female-dominated professions such as nanny or nurse—are frequently referred to in terms of their sexual availability or physical appearance. Applications Findings will have practical relevance for those interested in the recruitment, job satisfaction, and retention of practitioners, and in reducing the stigmatization of social workers and their clients. The innovative methodology employed in the study offers particular insights for social work researchers and also scriptwriters. The study evidences the ongoing need to support media professionals and the general public to better understand the challenges facing the profession and thereby reduce the tendency toward a culture of blaming individuals for society's failings.
Costotransverse joint ankylosis and their association with syndesmophyte progression in patients with radiographic axial spondyloarthritis
Authors: Min Hong Ki , Kim Se Hee , Lee Sang-Heon , Kim Hae-Rim , Lee Sang-Hoon 
Published: April 2024

Background: Abnormal new bone formation can occur not only in the vertebral body but also can occur in facet, costovertebral, and costotransverse joints in radiographic axial spondyloarthritis (r-axSpA) patients. Little is known about the association between syndesmophyte progression and paravertebral joint ankylosis in r-axSpA. Objectives: Costotransverse joint ankylosis in r-axSpA patients was measured. Furthermore, the association between syndesmophyte progression for 2 years assessed by computed tomography syndesmophyte score (CTSS) and facet, costovertebral, and costotransverse joints ankylosis were evaluated. Design: Single-center, prospective, cohort study. Methods: Whole spine CT images taken at baseline and 2-year follow-up were used to calculate the CTSS of the vertebral body. In addition, ankylosis of the facet/costovertebral/costotransverse joints was scored. CTSS (range, 0–552) and facet joint ankylosis (range, 0–46) were assessed at 23 vertebral units. Costovertebral joints at T1–T12 (range, 0–48) and costotransverse joints at T1–T10 (range, 0–20) were also assessed by independent two readers. Intraclass correlation coefficients (ICC) were calculated to determine inter-reader reliability. Odds ratios (OR) were calculated to identify the associations between syndesmophyte progression and the baseline status of facet, costovertebral, and costotransverse joints. Results: In all, 50 patients with r-axSpA were included. Readers 1 and 2 identified C7–T3 (facet joints), T5–T7 and T12 (costovertebral joints), and T8–T9 (costotransverse joints), as common sites of ankylosis at baseline and at 2-year follow-up. The ICCs for the facet, costovertebral, and costotransverse joints at baseline were 0.876, 0.952, and 0.753, respectively. OR of baseline costovertebral and costotransverse joint ankylosis for predicting syndesmophyte progression of the vertebral body was 4.644 [95% confidence interval (CI), 2.295–9.398] and 1.524 (95% CI, 1.036–2.244), respectively. Conclusion: Costotransverse joint ankylosis in r-axSpA patients can be measured semi-quantitatively on whole spine CT, and ankylosis of the costotransverse and costovertebral joints predicts the progression of syndesmophytes. Trial registration: Not applicable.
Wiskott-Aldrich syndrome: a study of 577 patients defines the genotype as a biomarker for disease severity and survival
Authors: Vallée Tanja C. , Glasmacher Jannik S. , Buchner Hannes , Arkwright Peter D. , Behrends Uta , Bondarenko Anastasia , Browning Michael J. , Buchbinder David , Cattoni Alessandro , Chernyshova Liudmyla , Ciznar Peter , Cole Theresa , Czogała Wojciech , Dueckers Gregor , Edgar John David M. , Erbey Fatih , Fasth Anders , Ferrua Francesca , Formankova Renata , Gambineri Eleonora , Gennery Andrew R. , Goldman Frederick D. , Gonzalez-Granado Luis I. , Heilmann Carsten , Heiskanen-Kosma Tarja , Juntti Hanna , Kainulainen Leena , Kanegane Hirokazu , Karaca Neslihan E. , Kilic Sara S. , Klein Christoph , Kołtan Sylwia , Kondratenko Irina , Meyts Isabelle , Nasrullayeva Gulnara M. , Notarangelo Lucia D. , Pasic Srdjan , Pellier Isabelle , Pignata Claudio , Misbah Siraj , Schulz Ansgar , Segundo Gesmar R. , Shcherbina Anna , Slatter Mary , Sokolic Robert , Soler-Palacin Pere , Stepensky Polina , van Montfrans Joris M. , Ryhänen Samppa , Wolska-Kuśnierz Beata , Ziegler John B. , Zhao Xiaodong , Aiuti Alessandro , Ochs Hans D. , Albert Michael H. 
Published: April 2024

Abstract
Wiskott-Aldrich syndrome (WAS) is a multifaceted monogenic disorder with a broad disease spectrum and variable disease severity and a variety of treatment options including allogeneic hematopoietic stem cell transplantation (HSCT) and gene therapy (GT). No reliable biomarker exists to predict disease course and outcome for individual patients. A total of 577 patients with a WAS variant from 26 countries and a median follow-up of 8.9 years (range, 0.3-71.1), totaling 6118 patient-years, were included in this international retrospective study. Overall survival (OS) of the cohort (censored at HSCT or GT) was 82% (95% confidence interval, 78-87) at age 15 years and 70% (61-80) at 30 years. The type of variant was predictive of outcome: patients with a missense variant in exons 1 or 2 or with the intronic hot spot variant c.559+5G&gt;A (class I variants) had a 15-year OS of 93% (89-98) and a 30-year OS of 91% (86-97), compared with 71% (62-81) and 48% (34-68) in patients with any other variant (class II; P &lt; .0001). The cumulative incidence rates of disease-related complications such as severe bleeding (P = .007), life-threatening infection (P &lt; .0001), and autoimmunity (P = .004) occurred significantly later in patients with a class I variant. The cumulative incidence of malignancy (P = .6) was not different between classes I and II. It confirms the spectrum of disease severity and quantifies the risk for specific disease-related complications. The class of the variant is a biomarker to predict the outcome for patients with WAS.
Plasma proteomic characterization of colorectal cancer patients with FOLFOX chemotherapy by integrated proteomics technology
Authors: Wang Xi , Zhang Keren , He Wan , Zhang Luobin , Gao Biwei , Tian Ruijun , Xu Ruilian 
Published: April 2024

Abstract
Background
Colorectal Cancer (CRC) is a prevalent form of cancer, and the effectiveness of the main postoperative chemotherapy treatment, FOLFOX, varies among patients. In this study, we aimed to identify potential biomarkers for predicting the prognosis of CRC patients treated with FOLFOX through plasma proteomic characterization.

Methods
Using a fully integrated sample preparation technology SISPROT-based proteomics workflow, we achieved deep proteome coverage and trained a machine learning model from a discovery cohort of 90 CRC patients to differentiate FOLFOX-sensitive and FOLFOX-resistant patients. The model was then validated by targeted proteomics on an independent test cohort of 26 patients.

Results
We achieved deep proteome coverage of 831 protein groups in total and 536 protein groups in average for non-depleted plasma from CRC patients by using a Orbitrap Exploris 240 with moderate sensitivity. Our results revealed distinct molecular changes in FOLFOX-sensitive and FOLFOX-resistant patients. We confidently identified known prognostic biomarkers for colorectal cancer, such as S100A4, LGALS1, and FABP5. The classifier based on the biomarker panel demonstrated a promised AUC value of 0.908 with 93% accuracy. Additionally, we established a protein panel to predict FOLFOX effectiveness, and several proteins within the panel were validated using targeted proteomic methods.

Conclusions
Our study sheds light on the pathways affected in CRC patients treated with FOLFOX chemotherapy and identifies potential biomarkers that could be valuable for prognosis prediction. Our findings showed the potential of mass spectrometry-based proteomics and machine learning as an unbiased and systematic approach for discovering biomarkers in CRC.
Yak genome database: a multi-omics analysis platform
Authors: Jiang Hui , Chai Zhi-Xin , Chen Xiao-Ying , Zhang Cheng-Fu , Zhu Yong , Ji Qiu-Mei , Xin Jin-Wei 
Published: April 2024

Abstract
Background
The yak (Bos grunniens) is a large ruminant species that lives in high-altitude regions and exhibits excellent adaptation to the plateau environments. To further understand the genetic characteristics and adaptive mechanisms of yak, we have developed a multi-omics database of yak including genome, transcriptome, proteome, and DNA methylation data.

Description
The Yak Genome Database (http://yakgenomics.com/) integrates the research results of genome, transcriptome, proteome, and DNA methylation, and provides an integrated platform for researchers to share and exchange omics data. The database contains 26,518 genes, 62 transcriptomes, 144,309 proteome spectra, and 22,478 methylation sites of yak. The genome module provides access to yak genome sequences, gene annotations and variant information. The transcriptome module offers transcriptome data from various tissues of yak and cattle strains at different developmental stages. The proteome module presents protein profiles from diverse yak organs. Additionally, the DNA methylation module shows the DNA methylation information at each base of the whole genome. Functions of data downloading and browsing, functional gene exploration, and experimental practice were available for the database.

Conclusion
This comprehensive database provides a valuable resource for further investigations on development, molecular mechanisms underlying high-altitude adaptation, and molecular breeding of yak.
Incidence and factors associated with failed spinal anaesthesia among patients undergoing surgery: a multi- center prospective observational study
Authors: Demilie Atalay Eshetie , Denu Zewditu Abdissa , Bizuneh Yosef Belay , Gebremedhn Endale Gebreegziabher 
Published: April 2024

Abstract
Background
Failed spinal anaesthesia causes prolonging of operation time, insufficient analgesia for surgery and needs repeating spinal anaesthesia which in turn causes local anaesthesia toxicity, high spinal and total spinal, and conversion to general anaesthesia. However, the problem remains unexplored in Amhara regional state comprehensive specialized hospitals.

Objective
To determine incidence and factors associated with failed spinal anaesthesia among patients undergoing surgery in selected Amhara National Regional State comprehensive specialized hospitals, Northwest Ethiopia, 2023.

Methods
Multi-center prospective observational study was conducted. Data was collected using questionnaire and checklist. All consecutive scheduled emergency and elective patients were included in the study. Data was transformed from Epi data to SPSS and logistic regression analysis was done. Both crude and adjusted odds ratio were used to assess the strength of association. Variables with a p-value of less than 0.05 were considered as statistically significant.

Results
A total of 532 patients were included in this study with a response rate of 98%. Incidence of failed spinal anaesthesia was 22.4% (CI = 19-25.9). Emergency surgery (AOR = 7.01, CI = 4.5–12.7), dose of bupivacaine of ≤ 10 mg (AOR = 3.02, CI = 1.3–10.2), work experience of anaesthetist < 2 years (AOR = 3.1, CI = 1.7–5.72), bloody CSF (AOR = 8.5, CI = 2.53–18.5), hyperbaric local anaesthetic drug (AOR = 3.3, 95% CI = 3.2–8.2) and local anaesthetist without adjuvants (AOR = 5.25, CI = 2.62–14.2) were associated failed spinal anaesthesia.

Conclusion and recommendation
The incidence of failed spinal anaesthesia was high in Amhara Region comprehensive specialized hospitals. We suggest that anaesthesia providers should minimize failure by using adjuvants and appropriate dose of local anaesthetic. Additionally, simulation training should be given for anaesthesia trainees to improve their skills and to produce competent professionals.
Serum albumin and cardiovascular disease: a Mendelian randomization study
Authors: Huang Taoke , An Zhifeng , Huang Ziru , Gao Weiyang , Hao Benchuan , Xu Juan 
Published: April 2024

Abstract
Background
An increasing body of evidence suggests that serum albumin levels play a role in cardiovascular diseases. However, the specific causal relationship between serum albumin levels and cardiovascular disease remains partially unknown.

Methods
Mendelian randomization (MR) was employed in this study to examine potential causal relationships between instrumental variables and cardiovascular diseases. Specifically, we utilized genetic variants of serum albumin levels within the reference range as our instrumental variables. To acquire data on genetic associations with cardiovascular diseases, we sourced information from renowned genome-wide association studies such as UK BioBank, EMBL-EBI, and FinnGen. Notably, our study leveraged summary statistics from large cohorts that have been previously described.

Results
We explored the association between serum albumin levels and various conditions, including heart failure (HF), venous thromboembolism (VTE), stroke, atrial fibrillation (AF), coronary artery disease (CAD), type 2 diabetes (T2DM), and pulmonary heart disease (PHD). Genetically predicted serum albumin levels were associated with PHD (odds ratio = 0.737, 95% CI = 0.622 − 0.874, P < 0.001), AF (odds ratio = 0.922, 95% CI = 0.870 − 0.977, P = 0.006), VTE (odds ratio = 0.993, 95% CI = 0.991 − 0.995, P < 0.001), and Stroke (odds ratio = 0.997, 95% CI = 0.995 − 0.999, P = 0.002). However, genetically predicted serum albumin level traits were not associated with HF, CAD and T2DM.

Conclusion
Our study demonstrates a significant association between serum albumin levels and cardiovascular disease, underscoring the crucial role of low serum albumin as a predictive factor in patients with cardiovascular disease.
Comparison of the effect of phenobarbital & levetiracetam in the treatment of neonatal abstinence syndrome (NAS) as adjuvant treatment in neonates admitted to the neonatal intensive care unit: a randomized clinical trial
Authors: Jamali Zahra , Molaei-Farsangi Mohammad Hosein , Ahmadipour Habibeh , Bahmanbijari Bahareh , Sabzevari Fatemeh , Parizi Zahra Daei 
Published: April 2024

Abstract
Background
Infants who are born from mothers with substance use disorder might suffer from neonatal abstinence syndrome (NAS) and need treatment with medicines. One of these medicines is phenobarbital, which may cause side effects in long-term consumption. Alternative drugs can be used to reduce these side effects. This study seeks the comparison of the effects of phenobarbital & levetiracetam as adjuvant therapy in neonatal abstinence syndrome.

Methods
This randomized clinical trial was performed in one year from May 2021 until May 2022. The neonates who were born from mothers with substance use disorder and had neonatal abstinence syndrome in Afzalipoor Hospital of Kerman were studied. The treatment started with morphine initially and every four hours the infants were checked. The infants who were diagnosed with uncontrolled symptoms After obtaining informed consent from the parents were randomly divided into two groups and treated with secondary drugs, either phenobarbital or levetiracetam.

Results
Based on the obtained results, it was clear that there was no significant difference between the hospitalization time of the two infant groups under therapy (phenobarbital: 18.59 days versus Levetiracetam 18.24 days) (P-value = 0.512). Also, there was no significant difference between both groups in terms of the frequency of re-hospitalization during the first week after discharge, the occurrence of complications, and third treatment line prescription (P-value = 0.644).

Conclusions
Based on the obtained results, like hospitalization duration time (P-value = 0.512) it seems that levetiracetam can be used to substitute phenobarbital in treating neonatal abstinence syndrome.

Trial registration
The current study has been registered in the Iran registry of clinical trials website (fa.irct.ir) on the date 25/2/2022 with registration no. IRCT20211218053444N2.