bluuebunny/crossref_metadata_2025_split huggingface dataset:
A new tandem repeat‐enriched lncRNA XLOC_008672 promotes gastric carcinogenesis by regulating G3BP1 expression
Authors: Li Li , Yu Shijun , Dou Ning , Wang Xiao , Gao Yong , Li Yandong 
Published: April 2024

AbstractAberrant expression of forkhead box transcription factor 1 (FOXM1) plays critical roles in a variety of human malignancies and predicts poor prognosis. However, little is known about the crosstalk between FOXM1 and long noncoding RNAs (lncRNAs) in tumorigenesis. The present study identifies a previously uncharacterized lncRNA XLOC_008672 in gastric cancer (GC), which is regulated by FOXM1 and possesses multiple copies of tandem repetitive sequences. LncRNA microarrays are used to screen differentially expressed lncRNAs in FOXM1 knockdown GC cells, and then the highest fold downregulation lncRNA XLOC_008672 is screened out. Sequence analysis reveals that the new lncRNA contains 62 copies of 37‐bp tandem repeats. It is transcriptionally activated by FOXM1 and functions as a downstream effector of FOXM1 in GC cells through in vitro and in vivo functional assays. Elevated expression of XLOC_008672 is found in GC tissues and indicates worse prognosis. Mechanistically, XLOC_008672 can bind to small nuclear ribonucleoprotein polypeptide A (SNRPA), thereby enhancing mRNA stability of Ras‐GTPase‐activating protein SH3 domain‐binding protein 1 (G3BP1) and, consequently, facilitating GC cell proliferation and migration. Our study discovers a new uncharacterized lncRNA XLOC_008672 involved in GC carcinogenesis and progression. Targeting FOXM1/XLOC_008672/SNRPA/G3BP1 signaling axis might be a promising therapeutic strategy for GC.
Contact allergy to topical ophthalmic medications: A retrospective single‐centre study of three decades
Authors: Svendsen Sebastian Vigand , Mortz Charlotte G. , Mose Kristian Fredløv 
Published: April 2024

AbstractBackgroundThe prevalence of contact allergy to various ophthalmic medications appears to be rare; however, data on culprits, clinical relevance of sensitizations, and changes in frequency within recent decades are limited.ObjectiveThis study aimed to investigate the clinical relevance, risk factors, and prevalence of contact allergy to topical ophthalmic medications in patients suspected of allergic contact dermatitis to ophthalmic medication.MethodsWe retrospectively analysed patch test results and clinical data for 754 patients patch‐tested with an ophthalmic medication series at our tertiary referral centre between January 1992 and December 2022.ResultsIn total, 37.5% (283/754) of patch‐tested patients had a contact allergy to at least one ophthalmic allergen, with 87.3% (247) being clinically relevant sensitization. Phenylephrine (31.8%, 192/604), povidone‐iodine (29%, 27/93), and tobramycin (23%, 46/200) were the most important sensitizers. The incidence of contact allergies increased significantly in a linear manner (p = 0.008) from 20% to 44.1% within the study period. Male sex and age above 40 were risk factors for contact allergy to ophthalmic medication.ConclusionsOne third of patch tested patients had allergic contact dermatitis to ophthalmic medication, particularly phenylephrine. Male sex and age above 40 years were independent risk factors and drove the linear increase in contact allergy to ophthalmic medications within the past 31 years.
Quantified trends in provider reimbursement and utilization volume in colorectal cancer screenings: analysis of Medicare claims from 2000 to 2019
Authors: Bommineni Vishal M. , Bommineni Vikas L. , Gupta Rohan 
Published: April 2024

AbstractAimColorectal cancer (CRC) screening rates in the United States remain persistently below guideline targets, partly due to suboptimal patient utilization and provider reimbursement. To guide long‐term national utilization estimates and set reasonable screening adherence targets, this study aimed to quantify trends in utilization of and reimbursement for CRC screenings using Medicare claims.MethodInflation‐adjusted reimbursements and utilization volume associated with each CRC screening code were abstracted from Medicare claims between 2000 and 2019. Screenings, screenings/100 000 enrolees and reimbursement/screening were analysed with linear regression and compared with the equality of slopes tests. Average reimbursement per screening was compared using analysis of variance with Dunnett's T3 multiple comparisons test.ResultsThe growth rate of multitarget stool DNA tests (mt‐sDNA)/100 000 was the highest at 170.4 screenings/year (R2 = 0.99, p ≤ 0.001), while that of faecal occult blood tests/100 000 was the lowest at −446.4 screenings/year (R2 = 0.90, p ≤ 0.001) (p ≤ 0.001). Provider reimbursements averaged $546.95 (95% CI $520.12–$573.78) per mt‐sDNA screening, significantly higher than reimbursements for all invasive screenings. Only FOBTs significantly increased in reimbursement per screening at $0.62/year (R2 = 0.91, p ≤ 0.001).ConclusionWe derived forecastable trend numbers for utilization and provider reimbursement. Faecal immunochemical tests/100 000 and mt‐sDNA screenings/100 000 increased most rapidly during the entire study period. The number of nearly all invasive screenings/100 000 decreased rapidly; the number of colonoscopies/100 000 increased slightly, probably due to superior diagnostic strength. These trends indicate the that replacement of other invasive modalities with accessible noninvasive screenings will account for much of future screening behaviour and thus reductions in CRC incidence and mortality, especially given providers' reimbursement incentive to screen average‐risk patients with stool‐based tests.
Supply of mental health practices after prescriptive authority expansion for psychologists
Authors: Shoulders Angela , Plemmons Alicia 
Published: April 2024

AbstractThe prescription‐privileges movement has advocated for state laws enabling trained psychologists to prescribe psychotropic medication. We examine the impact of these laws on healthcare access and outcomes. Using staggered difference‐in‐differences analysis and Data Axle data, we estimate the number of new mental health establishments per 100,000 people after policy implementation. Using CDC data, we analyze the policy's impact on suicide rates. We find the policy increased the number of psychology and counseling practices without decreasing the number of psychiatric practices, implying that these practices are complements rather than substitutes. Quality held steady, with no notable change in the suicide rate.
Elementos de datos comunes para la artrogriposis múltiple congénita: Un marco internacional
Authors: Nematollahi Shahrzad , Dieterich Klaus , Filges Isabel , De Vries Johanna I. P. , Van Bosse Harold , Natera de Benito Daniel , Hall Judith G. , Sawatzky Bonita , Bedard Tanya , Sanchez Victoria Castillo , Navalon‐Martinez Carolina , Pan Tony , Hilton Coleman , Dahan‐Oliel Noémi 
Published: April 2024

ResumenObjetivoPara facilitar los estudios multicéntricos y la investigación clínica internacional, este estudio pretende identificar de forma consensuada los elementos de datos estandarizados para la artrogriposis múltiple congénita (AMC).MétodoEstudio de métodos mixtos de grupos de discusión y tres rondas de encuestas Delphi modificadas para llegar a un consenso utilizando dos escalas de clasificación por niveles.ResultadosEn total, 45 expertos clínicos y adultos con experiencia vivida (incluidos 12 miembros de un consorcio de AMC) participaron en este estudio procedentes de 11 países: Norteamérica, Europa y Australia. Los CDEs incluyen 321 elementos de datos y 19 medidas estandarizadas en varios dominios desde el desarrollo fetal hasta la edad adulta. Los elementos de datos relativos a los rasgos fenotípicos del CDEs se mapearon de acuerdo con la Ontología de Fenotipos Humanos. Se identificaron como principales facilitadores la estructura de gobernanza universal, protocolos operados de forma local y los planes de sostenibilidad, mientras que los principales obstáculos observados son la capacidad limitada para compartir datos y la necesidad de una infraestructura informática federada.InterpretaciónLa recopilación de datos sistemáticos sobre la AMC mediante CDEs permitirá investigar las vías etiológicas, describir el perfil epidemiológico y establecer correlaciones genotipo‐fenotipo de forma estandarizada. Los CDEs propuestos facilitarán las colaboraciones multidisciplinares internacionales mejorando los estudios a gran escala y las oportunidades para compartir datos, translación de conocimiento y difusión.
Feasibility and prognostic value of tissue motion annular displacement in patients with heart transplantation
Authors: Ji Xiang , Zhang Yiwei , Xie Yuji , Zhao Ruohan , Li Yuman , Xie Mingxing , Zhang Li 
Published: April 2024

AbstractBackgroundTissue motion of mitral annular displacement (TMAD) assessment has proved to be an effective method for several cardiovascular diseases including hypertrophic cardiomyopathy, heart failure, non‐ST‐elevation myocardial infarction, etc. However, there are no studies exploring the feasibility of TMAD in heart transplantation (HT) recipients, and the predictive value of this parameter for adverse outcomes in these patients remains unknown. Consequently, this study aimed to evaluate the feasibility of TMAD in the evaluation of left ventricular (LV) systolic function in clinically well adult HT patients, and further investigate the prognostic value of TMAD.MethodsEchocardiography was performed in 155 adult HT patients and 49 healthy subjects. All the subjects were examined by conventional transthoracic two‐dimensional echocardiography and two‐dimensional speckle tracking echocardiography (2D‐STE) with evaluation of the LV end‐diastolic diameter, LV end‐diastolic volume index, LV end‐systolic volume index, interventricular septal thickness, left atrial diameter, mitral annular plane systolic excursion (MAPSE), LV ejection fraction (LVEF), TMAD and LV global longitudinal strain (LVGLS). The end point was defined as all‐causes mortality or posttransplant related hospitalization during follow up. Cox proportional hazards regression was performed to evaluate the prognostic value of the parameters for predicting poor outcomes in HT patients.ResultsA significant positive correlation was found between the measurements of TMAD and LVGLS (r = .714, p < .001). TMAD obtained by 2D‐STE had good reproducibility. The LVGLS and TMAD were significantly lower in HT group than in control group (both p < .001). In HT patients, compared with event free group, adverse outcome group displayed reduced TMAD and LVGLS, and elevated age (p < .001, < .001, = .017, respectively). Patients with higher TMAD (> 9.1 mm) had comparatively better survival when stratified by cutoff value (log‐rank p < .001). LVGLS and TMAD were independently associated with adverse outcomes in multivariable analysis (both p < .001).ConclusionAssessment of TMAD is effective for evaluating LV longitudinal systolic function and predicting adverse outcomes in clinically well adult HT patients.
Hurdles to financing micro‐entrepreneurs in MENA countries prior and during COVID‐19
Authors: Berguiga Imène , Adair Philippe 
Published: April 2024

AbstractFactors detrimental to funding females or micro‐entrepreneurs arise both from the demand side of businesses, such as the absence of funding need versus self‐selection despite account holding, and from the supply side of financial institutions, such as deficient financial infrastructure and discrimination towards loan applicants. A sequential model addresses both the demand and the supply sides, prior and during the COVID‐19 pandemic, upon four MENA countries, namely Egypt, Jordan, Morocco and Tunisia. Probit regressions use two distinct though comparable sub‐samples of micro‐enterprises from the 2020 World Bank Enterprise Survey (WBES) and the Economic Research Forum (ERF) COVID‐19 Monitor in 2021. Prior the pandemic, micro‐enterprises are prone to self‐selection vis‐à‐vis loan application in Tunisia (ERF) and in all North African countries (WBES). During the pandemic, no self‐selection vis‐à‐vis government support affects either female or micro‐entrepreneurs. Prior the pandemic, females or micro‐entrepreneurs face no loan discrimination (WBES). During the pandemic, females face no discrimination regarding government support, whereas Moroccan micro‐entrepreneurs do (ERF). Prior the pandemic, financial inclusion runs opposite to both self‐selection and discrimination (WBES), but not for self‐selection (ERF), whereas it proves insignificant during the pandemic with respect to self‐selection or discrimination, whatever the sub‐sample.
Behavioral responses of the lady beetles Cryptolaemus montrouzieri and Tenuisvalvae notata to specific mealybug prey
Authors: De La Pava Nataly , da Silva Torres Christian Sherley Araújo , Bento José Maurício S. 
Published: April 2024

AbstractLady beetles (Coleoptera: Coccinellidae) are important biocontrol agents that are considered generalist predators, although some tribes, such as Scymnini, are specialized in predation of sucking pests, such as mealybugs, aphids, and whiteflies. However, prey preference or pre‐imaginal conditioning may occur as coccinellids are subjected to large‐scale rearing. Thus, predator–prey interaction may be an outcome of conditioning to prey stimuli. To evaluate possible pre‐imaginal conditioning, population lines were created for the lady beetles Cryptolaemus montrouzieri Mulsant and Tenuisvalvae notata (Mulsant), each fed for at least eight generations the mealybugs Ferrisia dasylirii (Cockrell) or Planococcus citri Risso (Hemiptera: Pseudococcidae). Next, the behavioral response of these coccinellids was measured in arenas treated with prey volatiles or footprints, regarding walking time, walking speed, walking distance, and residence time. Finally, food preference between prey species was measured in laboratory and semi‐field conditions on infested cotton plants. Conditioned coccinellids responded similarly to volatiles released by either prey species offered. Furthermore, there were no changes in predator behavior towards footprints of either prey species. Both predator species consumed more P. citri in all tests, regardless of rearing prey indicating no pre‐imaginal conditioning. These results suggest that rearing prey may not affect the predator behavior, and both coccinellid species are effective in the biological control of mealybugs.
Undergraduate dental students' perceptions of dental pain in children – A grounded theory study
Authors: Roxner Rikard , Hallberg Ulrika , Berlin Henrik , Klingberg Gunilla 
Published: April 2024

AbstractIntroductionThere is an underuse of pain management strategies in dental care for children, possibly owing to perceived stress and discomfort when treating children, which has also been reported by dental students. The aim of this study was to explore how undergraduate dental students experience and understand pain related to dental treatment in children.Materials and MethodsInterviews were held with 21 Swedish dental students, from 3 dental schools, all in their final 2 years of education. The interviews were transcribed verbatim and analysed according to Grounded Theory.ResultsA core category, seeking guidance to avoid pain, was identified and related to 6 conceptual categories. The students used different strategies to manage pain prevention in child dentistry and to become skilled dentists. They described high levels of stress, as well as having high expectations on themselves when treating children. The stress led to a surface learning approach, something the students were not fully aware of.ConclusionAll children should have the right to be ensured optimal pain prevention in dental care. The basis for this is laid during undergraduate education. Thus, pain management in child dentistry is an area in need of special attention in this respect. The academic staff has an important role in supporting their students in their process to gain an identity as professional dentists. To ensure that students incorporate an understanding of the importance of pain prevention when treating children there is a need to create more integration between theory and clinical training in undergraduate education.
New stimulation procedures for language mapping in stereo‐EEG
Authors: Abarrategui Belén , Pelliccia Veronica , Giovannelli Ginevra , Nichelatti Michele , Valenzano Serena , Mikulan Ezequiel , Pigorini Andrea , Revay Martina , Scarpa Pina , Tassi Laura 
Published: April 2024

AbstractObjectiveCortical intracerebral electrical stimulation is an important tool for language mapping in the presurgical work‐up of patients with drug‐resistant focal epilepsy. Language mapping with stereo–electroencephalography (EEG) is usually performed by high‐frequency stimulations (HFS: 50 Hz), whereas low‐frequency stimulations (LFS: 1 Hz) are usually considered useful for primary cortices mapping. Little is known in literature about “intermediate” frequencies (IFS: 6–15 Hz). Our objective is to explore the clinical usefulness of IFS in language mapping and identify factors, beyond the electrical parameters, that impact the mapping.MethodsWe studied 23 patients submitted to stereo‐EEG for presurgical evaluation. Language mapping was performed in the anterior, posterior and/or basal language region of the dominant hemisphere for language. We included all contact positions within these regions stimulated by HFS (50 Hz, 5 s, 1–3 mA) and IFS (6‐15 Hz, 15 s, 5 mA). We compared the capability of both stimulation methods to induce a language deficit without afterdischarges (ADs), and we analyzed factors related to clinical examination, region, and stimulation technique by multivariate analysis.ResultsA total of 211 stimulations (98 HFS, 113 IFS) in 70 cortical sites within the anterior (84 stimulations), posterior (137), and basal language region (60) were included. IFS induced more frequently language deficits not associated to AD compared to HFS (37.1% vs 25.7%, p = .0043), whereas HFS provoked more diffuse AD (34.7% vs 15.0%, p = .001). Investigating multiple language functions increased the probability of revealing a deficit (odds ratio [OR] 3.16, p = .0016), independently of the stimulation method.SignificanceIFS are valuable for language mapping, thereby improving the probability of inducing a clinical deficit not accompanied by an AD. The completeness of the clinical examination independently affects the sensitivity of the mapping. IFS are a new tool with potential usefulness for the cortical mapping of other associative cortical regions.
Epilepsy surgery in adults older than 50 years: A systematic review and meta‐analysis
Authors: Vary O’Neal Arielle , Tamani Ishak , Mendo Christian W. , Josephson Colin B. , Burneo Jorge G. , Steven David A. , Keezer Mark R. 
Published: April 2024

AbstractObjectiveDespite the general safety and efficacy of epilepsy surgery, there is evidence that epilepsy surgery remains underutilized. Although there are an increasing number of studies reporting epilepsy surgery in older adults, there is no consensus on whether epilepsy surgery is efficacious or safe for this population. Our objective was to systematically assess the efficacy as well as safety of resective surgery in people aged 50 years or older with drug‐resistant epilepsy.MethodsWe considered studies that examine the efficacy and safety of epilepsy surgery in adults aged 50 years and older. Study eligibility was limited to studies carried out after 1990, with a minimum of 10 participants and 6 months of follow‐up. We searched the following databases for published studies: Ovid MEDLINE, Ovid Embase, Cumulative Index to Nursing and Allied Health Literature, PsychInfo, and Web of Science Conference Proceedings Citation Index ‐ Science. The risk of bias of each included study was independently assessed by two reviewers using the MINORS (Methodological Index for Non‐Randomized Studies) instrument.ResultsEleven case series and 14 cohort studies met the criteria for inclusion, for a total of 1111 older adults who underwent epilepsy surgery along with 4111 adults younger than 50 years as control groups. The pooled cumulative incidence of older adults achieving seizure freedom after resective surgery was 70.1% (95% confidence interval [CI] = 65.3–74.7). There was no evident difference in the incidence of seizure freedom among older adults as compared to younger adults (risk ratio [RR] = 1.05, 95% CI = .97–1.14) in cohort studies. The pooled cumulative incidence of perioperative complications in older adults was 26.2% (95% CI = 21.3–31.7). Among them, 7.5% (95% CI = 5.8–9.5) experienced major complications. Older adults were significantly more at risk of experiencing any complication than younger adults (RR = 2.8, 95% CI = 1.5–5.4).SignificanceDespite important considerations, epilepsy surgery may be considered appropriate among carefully selected individuals older than 50 years.
Replicated whole‐lake experiment reveals the ineffectiveness of stocking five example fish species in small lakes
Authors: Matern Sven , Radinger Johannes , Klefoth Thomas , Wolter Christian , Arlinghaus Robert 
Published: April 2024

AbstractFish stocking is common practice in fisheries management, but its effectiveness to support or increase stock size or catches is debated. In Lower Saxony, Germany, a controlled, replicated stocking experiment of five native fish species in eight gravel pit lakes <20 ha was conducted to examine the potential additive effects of fish releases on abundance, indexed by catch per unit effort (CPUE) in electrofishing and gillnet samples. Fish were stocked twice in four study lakes, while the remaining four control lakes were not subjected to any stocking over a 6‐year study period. Recapture rates of individually marked fishes were extremely low in all five species. Consequently, stocking did not increase species‐specific and total fish community abundance. In additional control experiments in separate ponds all stocked fish species, except bream (Abramis brama), showed high survival in at least one study year, indicating general survival of the stocking material. Fish marking with passive integrated transponders did not affect fish survival, except for roach (Rutilus rutilus), and can thus be ruled out as an explanation for the high post‐stocking mortality. We conclude that stocking failed to enhance stocks of five native fish species in small gravel pit lakes.