bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship between medication burden and medication experience in stable patients with schizophrenia: the mediating effect of medication belief
Authors: Sun Yujing , Yu Hong , Wang Zhengjun , Zhang Jing , Zhou Yuqiu , Cui Wenming , Jiang Wenlong 
Published: March 2024

Abstract
Background
Individuals with schizophrenia require prolonged antipsychotic medication treatment. But more than 50% of individuals with schizophrenia experience adverse medication experiences during their antipsychotic treatments. Such individuals often adjust or discontinue medication, leading to disease relapse and impaired social functioning. Psychiatric nurses should pay close attention to the medication experiences of individuals with schizophrenia. This research explore the relationship between medication burden and medication experience, as well as the mediating effect of medication belief in stable patients with schizophrenia.

Methods
A convenience sample of hospitalized stable patients with schizophrenia were selected from Daqing Third Hospital and Baiyupao Hospital from September 2023 to December 2023. A survey was conducted with them using a questionnaire consisting of general information questionnaire, The Subjective Well-being Under Neuroleptic Treatment Scale(SWN), The Living with Medicines Questionnaire(LMQ), Beliefs about Medicines Questionnaire-Specific (BMQ-Specific). Pearson correlation analysis was used to explore the correlation between LMQ, BMQ-Specific and SWN scores, and multiple linear regression analysis was used to explore the influencing factors of medication experience in patients with schizophrenia. AMOS 24.0 was used to construct the structural equation modeling(SEM), and the mediation effect of the SEM was tested using Bootstrap method.

Results
According to the sample size calculation requirements of structural equation model, a total of 300 samples were required in this study, and 400 effective questionnaires were actually collected in this study, which met the sample size requirements for constructing structural equation models. Bootstrap test showed that the mediation effect was significant. The total effect of medication burden on medication experience was significant (Z=-12.146, 95%CI (-0.577, -0.417), P < 0.001). The indirect effect of medication burden on medication experience, that is, the mediating effect of medication belief was significant (Z=-4.839, 95%CI (-0.217, -0.096), P < 0.001). The direct effect of medication burden on medication experience was significant (Z=-7.565, 95%CI (-0.437, -0.257), P < 0.001). This model belongs to partial mediation model.

Conclusions
Psychiatric nurses can enhance the patients’ medication experience by reducing medication burden and strengthening medication beliefs. Therefore, the results also provide theoretical references and decision-making foundations for psychiatric nursing professionals to develop appropriate management strategies for individuals with schizophrenia.
Phylogenomics resolves the higher-level phylogeny of herbivorous eriophyoid mites (Acariformes: Eriophyoidea)
Authors: Zhang Qi , Lu Yi-Wen , Liu Xin-Yu , Li Ye , Gao Wei-Nan , Sun Jing-Tao , Hong Xiao-Yue , Shao Renfu , Xue Xiao-Feng 
Published: March 2024

AbstractBackgroundEriophyoid mites (Eriophyoidea) are among the largest groups in the Acariformes; they are strictly phytophagous. The higher-level phylogeny of eriophyoid mites, however, remains unresolved due to the limited number of available morphological characters—some of them are homoplastic. Nevertheless, the eriophyoid mites sequenced to date showed highly variable mitochondrial (mt) gene orders, which could potentially be useful for resolving the higher-level phylogenetic relationships.ResultsHere, we sequenced and compared the complete mt genomes of 153 eriophyoid mite species, which showed 54 patterns of rearranged mt gene orders relative to that of the hypothetical ancestor of arthropods. The shared derived mt gene clusters support the monophyly of eriophyoid mites (Eriophyoidea) as a whole and the monophylies of six clades within Eriophyoidea. These monophyletic groups and their relationships were largely supported in the phylogenetic trees inferred from mt genome sequences as well. Our molecular dating results showed that Eriophyoidea originated in the Triassic and diversified in the Cretaceous, coinciding with the diversification of angiosperms.ConclusionsThis study reveals multiple molecular synapomorphies (i.e. shared derived mt gene clusters) at different levels (i.e. family, subfamily or tribe level) from the complete mt genomes of 153 eriophyoid mite species. We demonstrated the use of derived mt gene clusters in unveiling the higher-level phylogeny of eriophyoid mites, and underlines the origin of these mites and their co-diversification with angiosperms.
LINC00115 promotes chemoresistant breast cancer stem-like cell stemness and metastasis through SETDB1/PLK3/HIF1α signaling
Authors: Luo Fei , Zhang Mingda , Sun Bowen , Xu Chenxin , Yang Yi , Zhang Yingwen , Li Shanshan , Chen Guoyu , Chen Ceshi , Li Yanxin , Feng Haizhong 
Published: March 2024

Abstract
Background
Cancer stem-like cell is a key barrier for therapeutic resistance and metastasis in various cancers, including breast cancer, yet the underlying mechanisms are still elusive. Through a genome-wide lncRNA expression profiling, we identified that LINC00115 is robustly upregulated in chemoresistant breast cancer stem-like cells (BCSCs).

Methods
LncRNA microarray assay was performed to document abundance changes of lncRNAs in paclitaxel (PTX)-resistant MDA-MB-231 BCSC (ALDH+) and non-BCSC (ALDH−). RNA pull-down and RNA immunoprecipitation (RIP) assays were performed to determine the binding proteins of LINC00115. The clinical significance of the LINC00115 pathway was examined in TNBC metastatic lymph node tissues. The biological function of LINC00115 was investigated through gain- and loss-of-function studies. The molecular mechanism was explored through RNA sequencing, mass spectrometry, and the CRISPR/Cas9-knockout system. The therapeutic potential of LINC00115 was examined through xenograft animal models.

Results
LINC00115 functions as a scaffold lncRNA to link SETDB1 and PLK3, leading to enhanced SETDB1 methylation of PLK3 at both K106 and K200 in drug-resistant BCSC. PLK3 methylation decreases PLK3 phosphorylation of HIF1α and thereby increases HIF1α stability. HIF1α, in turn, upregulates ALKBH5 to reduce m6A modification of LINC00115, resulting in attenuated degradation of YTHDF2-dependent m6A-modified RNA and enhanced LINC00115 stability. Thus, this positive feedback loop provokes BCSC phenotypes and enhances chemoresistance and metastasis in triple-negative breast cancer. SETDB1 inhibitor TTD-IN with LINC00115 ASO sensitizes PTX-resistant cell response to chemotherapy in a xenograft animal model. Correlative expression of LINC00115, methylation PLK3, SETDB1, and HIF1α are prognostic for clinical triple-negative breast cancers.

Conclusions
Our findings uncover LINC00115 as a critical regulator of BCSC and highlight targeting LINC00115 and SETDB1 as a potential therapeutic strategy for chemotherapeutic resistant breast cancer.
TCMNPAS: a comprehensive analysis platform integrating network formulaology and network pharmacology for exploring traditional Chinese medicine
Authors: Liu Yishu , Li Xue , Chen Chao , Ding Nan , Zheng Peiyong , Chen Xiaoyun , Ma Shiyu , Yang Ming 
Published: March 2024

AbstractThe application of network formulaology and network pharmacology has significantly advanced the scientific understanding of traditional Chinese medicine (TCM) treatment mechanisms in disease. The field of herbal biology is experiencing a surge in data generation. However, researchers are encountering challenges due to the fragmented nature of the data and the reliance on programming tools for data analysis. We have developed TCMNPAS, a comprehensive analysis platform that integrates network formularology and network pharmacology. This platform is designed to investigate in-depth the compatibility characteristics of TCM formulas and their potential molecular mechanisms. TCMNPAS incorporates multiple resources and offers a range of functions designed for automated analysis implementation, including prescription mining, molecular docking, network pharmacology analysis, and visualization. These functions enable researchers to analyze and obtain core herbs and core formulas from herbal prescription data through prescription mining. Additionally, TCMNPAS facilitates virtual screening of active compounds in TCM and its formulas through batch molecular docking, allowing for the rapid construction and analysis of networks associated with “herb-compound-target-pathway” and disease targets. Built upon the integrated analysis concept of network formulaology and network pharmacology, TCMNPAS enables quick point-and-click completion of network-based association analysis, spanning from core formula mining from clinical data to the exploration of therapeutic targets for disease treatment. TCMNPAS serves as a powerful platform for uncovering the combinatorial rules and mechanism of TCM formulas holistically. We distribute TCMNPAS within an open-source R package at GitHub (https://github.com/yangpluszhu/tcmnpas), and the project is freely available athttp://54.223.75.62:3838/.
The crosstalk between cholangiocytes and hepatic stellate cells promotes the progression of epithelial-mesenchymal transition and periductal fibrosis during Clonorchis sinensis infection
Authors: Yi Junyeong , Jeong Ji Hoon , Won Jihee , Chung Seok , Pak Jhang Ho 
Published: March 2024

A﻿bstract
Background
Clonorchis sinensis infection is one of the risk factors that provokes chronic inflammation, epithelial hyperplasia, periductal fibrosis and even cholangiocarcinoma (CCA). Disrupted or aberrant intercellular communication among liver-constituting cells leads to pathological states that cause various hepatic diseases. This study was designed to investigate the pathological changes caused by C. sinensis excretory-secretory products (ESPs) in non-cancerous human cell lines (cholangiocytes [H69 cell line] and human hepatic stellate cells [LX2 cell line]) and their intercellular crosstalk, as well the pathological changes in infected mouse liver tissues.

Methods
The cells were treated with ESPs, following which transforming growth factor beta 1 (TGF-β1) and interleukin-6 (IL-6) secretion levels and epithelial-mesenchymal transition (EMT)- and fibrosis-related protein expression were measured. The ESP-mediated cellular motility (migration/invasion) between two cells was assessed using the Transwell and three-dimensional microfluidic assay models. The livers of C. sinensis-infected mice were stained using EMT and fibrotic marker proteins.

Results
Treatment of cells with ESPs increased TGF-β1 and IL-6 secretion and the expression of EMT- and fibrosis-related proteins. The ESP-mediated mutual cell interaction further affected the cytokine secretion and protein expression levels and promoted cellular motility. N-cadherin overexpression and collagen fiber deposition were observed in the livers of C. sinensis-infected mice.

Conclusions
These findings suggest that EMT and biliary fibrosis occur through intercellular communication between cholangiocytes and hepatic stellate cells during C. sinensis infection, promoting malignant transformation and advanced hepatobiliary abnormalities.

Graphical Abstract
Waste analysis and energy use estimation during MR-HIFU treatment: first steps towards calculating total environmental impact
Authors: Anneveldt Kimberley J. , Nijholt Ingrid M. , Schutte Joke M. , Hehenkamp Wouter J. K. , Veersema Sebastiaan , Huirne Judith A. F. , Boomsma Martijn F. 
Published: March 2024

Abstract
Objectives
To assess the environmental impact of the non-invasive Magnetic Resonance image-guided High-Intensity Focused Ultrasound (MR-HIFU) treatment of uterine fibroids, we aimed to perform a full Life Cycle Assessment (LCA). However, as a full LCA was not feasible at this time, we evaluated the CO2 (carbon dioxide) emission from the MRI scanner, MR-HIFU device, and the medication used, and analyzed solid waste produced during treatment.

Methods
Our functional unit was one uterine fibroid MR-HIFU treatment. The moment the patient entered the day care-unit until she left, defined our boundaries of investigation. We retrospectively collected data from 25 treatments to assess the CO2 emission based on the energy used by the MRI scanner and MR-HIFU device and the amount and type of medication administered. Solid waste was prospectively collected from five treatments.

Results
During an MR-HIFU treatment, the MRI scanner and MR-HIFU device produced 33.2 ± 8.7 kg of CO2 emission and medication administered 0.13 ± 0.04 kg. A uterine fibroid MR-HIFU treatment produced 1.2 kg (range 1.1–1.4) of solid waste.

Conclusions
Environmental impact should ideally be analyzed for all (new) medical treatments. By assessing part of the CO2 emission and solid waste produced, we have taken the first steps towards analyzing the total environmental impact of the MR-HIFU treatment of uterine fibroids. These data can contribute to future studies comparing the results of MR-HIFU LCAs with LCAs of other uterine fibroid therapies.

Critical relevance statement
In addition to (cost-) effectiveness, the environmental impact of new treatments should be assessed. We took the first steps towards analyzing the total environmental impact of uterine fibroid MR-HIFU.

Key points
• Life Cycle Assessments (LCAs) should be performed for all (new) medical treatments.
• We took the first steps towards analyzing the environmental impact of uterine fibroid MR-HIFU.
• Energy used by the MRI scanner and MR-HIFU device corresponded to 33.2 ± 8.7 kg of CO2 emission.

Graphical Abstract
A comparative study assessing the efficacy and safety of radiofrequency ablation versus surgical treatment for osteoid osteoma: retrospective analysis in a single institution
Authors: Igrec Jasminka , Smolle Maria Anna , Meszarics Michael , Godschachner Theresa Marie , Steiner Jakob , Feichtinger Mira , Talakic Emina , Portugaller Rupert Horst , Leithner Andreas , Fuchsjäger Michael , Brcic Iva 
Published: March 2024

Abstract
Objective
We aim to evaluate the efficacy of CT-guided percutaneous radiofrequency ablation (RFA) and surgical treatment in osteoid osteoma (OO) treated at the Medical University of Graz.

Materials and methods
In a single-institution study, we analysed data from January 2005 to January 2021 of patients with histological/radiological diagnosis of OO. CT and MRI scans were reviewed for typical findings. Means (with SD) and medians (with IQR) were reported for normally and non-normally distributed variables. Differences between groups were assessed using chi-squared tests and t-tests.

Results
One hundred nineteen patients (mean age: 21.6 ± 10.9 years; 63.9% males) with confirmed OO were retrospectively evaluated. 73 and 43 patients underwent RFA and surgery, respectively. In three cases, RFA combined with surgery was performed. Pre-intervention, 103 patients (88.8%) had undergone CT, and 101 had an MRI (87.1%). The nidus was confirmed in 82.5% of cases with CTs (85/103) and 63.4% with MRIs (64/101). The majority of nidi were located cortically (n = 96; 82.8%), most frequently in the femur (38 patients, 33.3%) with a median size of 8.0 mm (IQR: 5.0–12.0 mm). Median symptom duration before treatment was 6.0 (IQR: 4.0–13.0) months. The complication rate was 12.1% (14/116; 15.1% RFA vs. 7.0% surgery; p = 0.196). In total, 11.2% of patients had persistent symptoms after one week with clinical success rates of RFA and surgery, 86.3% and 90.7% (p = 0.647), respectively.

Conclusion
Compared to surgical treatment, CT-guided percutaneous RFA is a safe, minimally invasive, reliable, and efficient treatment option for OO.

Critical relevance statement
This article critically assesses the diagnosis and treatment of osteoid osteoma, emphasising accurate imaging, and detailing a non-invasive option for effective management.

Key points
• This study analyses 116 cases of OO at one institution, focusing on symptom persistence, recurrence in short-term follow-up, and complications in two study groups.
• Surgery showed higher, though not statistically significant, success despite comparable symptom persistence; CT displayed typical OO features more than MRI, regardless of the intramedullary, cortical and subperiosteal location as well as the site of the affected bone.
• CT-guided RFA is an effective therapeutic alternative for OO compared to surgical intervention. In case of atypical OO appearance, RFA is not the first-line treatment.

Graphical Abstract
A highly efficient resource slicing and scheduling optimization algorithm for power heterogeneous communication networks based on hypergraph and congruence entropy
Authors: Wang Wendi , Jiang Chengling , Yang Linqing , Zhu Hong , Zhou Dongxu 
Published: March 2024

AbstractNew services, such as distributed photovoltaic regulation and control, pose new service requirements for communication networks in the new power system. These requirements include low latency, high reliability, and large bandwidth. Consequently, power heterogeneous communication networks face the challenge of maintaining quality of service (QoS) while enhancing network resource utilization. Therefore, this paper puts forward a highly efficient optimization algorithm for resource slicing and scheduling in power heterogeneous communication networks. Our first step involves establishing an architectural description model of heterogeneous wireless networks for electric power based on hypergraph. This model characterizes complex dynamic relationships among service requirements, virtual networks, and physical networks. The system congruence entropy characterizes the degree of matching between the service demand and resource supply. Then an optimization problem is formed to maximize the system congruence entropy through dynamic resource allocation. To solve this problem, a joint resource allocation and routing method based on Lagrangian dual decomposition is proposed. These methods provide the optimal solutions of the nodes and link mappings of service function chains. The simulation results demonstrate that the proposed algorithm in this paper can greatly enhance resource utilization and also meet the QoS requirements of various services.
Evaluation of residential building damage for the July 2021 flood in Westport, New Zealand
Authors: Paulik Ryan , Wild Alec , Zorn Conrad , Wotherspoon Liam , Williams Shaun 
Published: March 2024

AbstractReliable flood damage models are informed by detailed damage assessments. Damage models are critical in flood risk assessments, representing an elements vulnerability to damage. This study evaluated residential building damage for the July 2021 flood in Westport, New Zealand. We report on flood hazard, exposure and damage features observed for 247 residential buildings. Damage samples were applied to evaluate univariable and multivariable model performance using different variable sample sizes and regression-based supervised learning algorithms. Feature analysis for damage prediction showed high importance of water depth variables and low importance for commonly observed building variables such as structural frame and storeys. Overfitting occurred for most models evaluated when more than 150 samples were used. This resulted from limited damage heterogeneity observed, and variables of low importance affecting model learning. The Random Forest algorithm, which considered multiple important variables (water depth above floor level, area and floor height) improved predictive precision by 17% relative to other models when over 150 damage samples were considered. Our findings suggest the evaluated model performance could be improved by incorporating heterogeneous damage samples from similar flood contexts, in turn increasing capacity for reliable spatial transfer.
Thermal modeling of subduction zones with prescribed and evolving 2D and 3D slab geometries
Authors: Sime Nathan , Wilson Cian R. , van Keken Peter E. 
Published: March 2024

AbstractThe determination of the temperature in and above the slab in subduction zones, using models where the top of the slab is precisely known, is important to test hypotheses regarding the causes of arc volcanism and intermediate-depth seismicity. While 2D and 3D models can predict the thermal structure with high precision for fixed slab geometries, a number of regions are characterized by relatively large geometrical changes over time. Examples include the flat slab segments in South America that evolved from more steeply dipping geometries to the present day flat slab geometry. We devise, implement, and test a numerical approach to model the thermal evolution of a subduction zone with prescribed changes in slab geometry over time. Our numerical model approximates the subduction zone geometry by employing time dependent deformation of a Bézier spline that is used as the slab interface in a finite element discretization of the Stokes and heat equations. We implement the numerical model using the FEniCS open source finite element suite and describe the means by which we compute approximations of the subduction zone velocity, temperature, and pressure fields. We compute and compare the 3D time evolving numerical model with its 2D analogy at cross-sections for slabs that evolve to the present-day structure of a flat segment of the subducting Nazca plate.
Beckwith–Wiedemann syndrome with juvenile fibrous nodules and lobular breast tumors: a case report and review of the literature
Authors: Sato Yo , Watanabe Yusuke , Morisaki Takafumi , Hayashi Saori , Otsubo Yoshiki , Ochiai Yurina , Mizoguchi Kimihisa , Takao Yuka , Yamada Mai , Mizuuchi Yusuke , Nakamura Masafumi , Kubo Makoto 
Published: March 2024

Abstract
Background
Beckwith–Wiedemann syndrome (BWS) is a genomic imprinting disorder caused by diverse genetic and/or epigenetic disorders of chromosome 11p15.5. BWS presents with a variety of clinical features, including overgrowth and an increased risk of embryonal tumors. Notably however, reports of patients with BWS and breast tumors are rare, and the association between these conditions is still unclear. Insulin-like growth factor-2 (IGF2) expression is known to be associated with the development of various cancers, including breast cancer, and patients with BWS with specific subtypes of molecular defects are known to show characteristic clinical features and IGF2 overexpression.

Case presentation
A 17-year-old girl who had been diagnosed with BWS based on an umbilical hernia, hyperinsulinemia, and left hemihypertrophy at birth, visited our department with a gradually swelling left breast. Her left breast was markedly larger than her right breast on visual examination. Imaging examinations showed two tumors measuring about 10 cm each in the left breast, and she was diagnosed with juvenile fibroadenoma following core needle biopsy. The two breast tumors were removed surgically and the patient remained alive with no recurrence. The final diagnosis was juvenile fibroadenoma without malignant findings. Immunohistochemical staining using IGF2 antibody revealed overexpression of IGF2 in the cytoplasm of ductal epithelial cells. Because of her clinical features and IGF2 overexpression, molecular defects of 11p15.5 including a possible genetic background of paternal uniparental disomy of chromosome 11 or hypermethylation of imprinting center 1 was suspected.

Conclusions
In this case, overexpression of IGF2 suggested a possible relationship between BWS and breast tumors. Moreover, the characteristic clinical features and IGF2 staining predicted the subtype of 11p15.5 molecular defects in this patient.