bluuebunny/crossref_metadata_2025_split huggingface dataset:
Focal finger palsy and wrist pain due to cortical infarction: a case report
Authors: Hu Shiyu , Wang Yang , Ren Lijie 
Published: February 2024

Abstract
Background
Hand knob infarction induced focal weakness of contralateral hand or distal arm, only accounts for less than 1% of all ischemic strokes. To date, there is no case with pain during sleep as the onset symptoms being reported. The atypical symptoms of hand knob infarction might increase the risk of delaying treatment especially in the hyperacute phase of stroke.

Case presentation
A 70-year-old man awoke from sleep due to sudden pain of his right medial wrist and presented to the emergency department with difficulty extending his right index and middle fingers within the time window of intravenous thrombolysis. But the intravenous thrombolysis was not given based on the NIHSS score (0) and atypical symptoms. MRI showed multiple DWI hyperintense lesions, including partial left hand knob area and left posterior central gyrus. CTA showed a severe focal stenosis of proximal left internal carotid artery.

Conclusions
The hand knob infarction might onset with unusual pain and should be carefully inspected in patients combined with acute onset of focal hand paresis.
US Food and Drug Administration Approval Summary: Elacestrant for Estrogen Receptor–Positive, Human Epidermal Growth Factor Receptor 2–Negative, ESR1-Mutated Advanced or Metastatic Breast Cancer
Authors: Shah Mirat , Lingam Hima , Gao Xin , Gittleman Haley , Fiero Mallorie H. , Krol Danielle , Biel Nikolett , Ricks Tiffany K. , Fu Wentao , Hamed Salaheldin , Li Fang , Sun Jillian (Jielin) , Fan Jianghong , Schuck Robert , Grimstein Manuela , Tang Liuya , Kalavar Shyam , Abukhdeir Abdelrahmman , Pathak Anand , Ghosh Soma , Bulatao Ilynn , Tilley Amy , Pierce William F. , Mixter Bronwyn D. , Tang Shenghui , Pazdur Richard , Kluetz Paul , Amiri-Kordestani Laleh 
Published: February 2024

PURPOSE The US Food and Drug Administration (FDA) approved elacestrant for the treatment of postmenopausal women or adult men with estrogen receptor–positive (ER+), human epidermal growth factor receptor 2–negative (HER2–), estrogen receptor 1 ( ESR1)–mutated advanced or metastatic breast cancer with disease progression after at least one line of endocrine therapy (ET). PATIENTS AND METHODS Approval was based on EMERALD (Study RAD1901-308), a randomized, open-label, active-controlled, multicenter trial in 478 patients with ER+, HER2– advanced or metastatic breast cancer, including 228 patients with ESR1 mutations. Patients were randomly assigned (1:1) to receive either elacestrant 345 mg orally once daily (n = 239) or investigator's choice of ET (n = 239). RESULTS In the ESR1-mut subgroup, EMERALD demonstrated a statistically significant improvement in progression-free survival (PFS) by blinded independent central review assessment (n = 228; hazard ratio [HR], 0.55 [95% CI, 0.39 to 0.77]; P value = .0005). Although the overall survival (OS) end point was not met, there was no trend toward a potential OS detriment (HR, 0.90 [95% CI, 0.63 to 1.30]) in the ESR1-mut subgroup. PFS also reached statistical significance in the intention-to-treat population (ITT, N = 478; HR, 0.70 [95% CI, 0.55 to 0.88]; P value = .0018). However, improvement in PFS in the ITT population was primarily attributed to results from patients in the ESR1-mut subgroup. More patients who received elacestrant experienced nausea, vomiting, and dyslipidemia. CONCLUSION The approval of elacestrant in ER+, HER2– advanced or metastatic breast cancer was restricted to patients with ESR1 mutations. Benefit-risk assessment in the ESR1-mut subgroup was favorable on the basis of a statistically significant improvement in PFS in the context of an acceptable safety profile including no evidence of a potential detriment in OS. By contrast, the benefit-risk assessment in patients without ESR1 mutations was not favorable. Elacestrant is the first oral estrogen receptor antagonist to receive FDA approval for patients with ESR1 mutations.
Design of floating formulations and antiulcer activity of Desmostachya bipinnata
Authors: Putta Sanjay Kumar , KB Koteshwara , Nayak Usha Y. , Pai K Sreedhara Ranganath , Pathuri Raghuveer , HN Aswatha Ram 
Published: February 2024

AbstractThe study aims to design and optimize the floating formulations of the aqueous extract of Desmostachya bipinnata (ADB) to treat peptic ulcers. The trial concentrations of HPMC E50, HPMC K4M, and Carbopol 940 were used as factors, and floating lag time, total floating time, and % drug release at 12 h were used as responses. The formulation underwent evaluation for different parameters: aspirin-induced ulcers in rats assessed the antiulcer activity, and X-ray studies in rabbits evaluated the gastroretentive nature. The optimized formulation has shown a floating lag time of 32 s and floated in the gastric medium for more than 9 h with a maximum drug release of 93% at the end of 12 h by following the Korsmeyer-Peppas drug release mechanism. The optimized formulation has good flow properties. The FT-IR, DSC, and XRD studies show ADB and excipients didn't show any incompatibility. The formulation has shown significant antiulcer activity against aspirin-induced ulcers in rats, with an ulcer index of 3.38 ± 0.24 and inhibition of 76.67 ± 0.56%. The in vivo X-ray imaging proved the gastric retention of the formulations for more than 8 h. The results of the formulations demonstrate the floating ability and sustained drug release of the tablet responsible for treating peptic ulcers to show a localized effect in the gastric region and to maintain the ROS levels.
Graphical Abstract
Remarks on the
Duffin-Kemmer-Petiau oscillator in an external magnetic field
Authors: Jirón Andrés G. , Castro Luis B. , Obispo Angel E. , de Castro Antonio S. 
Published: February 2024

Abstract
This work re-examines the issue of spin-1 particles in a (2+1)-dimensional Duffin-Kemmer-Petiau oscillator (DKPO) in the presence of an external magnetic field. By following the appropriate procedure for the spin-1 sector of the Duffin-Kemmer-Petiau (DKP) theory, the previously used 6 × 6 representation in the literature is shown to be reducible to a 3 × 3 irreducible representation. This approach enabled us to find new aspects of the results recently disseminated in various studies, as well as other considerations overlooked and requiring revision. Finally, we present some applications of two-dimensional DKP theory in condensed-matter systems, particularly in Lieb lattices.
Quadripartite quantum steering generated by single-pass cascaded nonlinear processes
Authors: Shen Y. R. , Jiang Y. X. , Cheng X. Y. , Lv J. W. , Yu Y. B. , Jin G. R. , Chen A. X. 
Published: February 2024

Abstract
Quantum steering has become an important resource for quantum information due to its unique asymmetry. In this paper, quadripartite quantum steering generated by single-pass nondegenerate optical parametric amplification cascaded with a sum-frequency process is investigated. Firstly, an idler beam is produced by a different-frequency process between pump and signal. Secondly, a sum-frequency beam is generated by a cascaded sum-frequency process between idler beam and pump in the same optical superlattice. Quadripartite quantum steering among pump, signal, idler and sum-frequency beams is demonstrated based on the criterion for multipartite quantum steering. The influences of nonlinear coupling coefficients κ, dimensionless propagation length ξ, and the initial values of pump and signal on the variation characteristic of the quadripartite steering are also investigated. The results indicate that slightly larger nonlinear coupling coefficients of cascaded nonlinear processes and weaker signals can achieve better quadripartite quantum steering. This simple quadripartite quantum steering preparation scheme does not require a resonant cavity and is easier to implement experimentally, with potential applications in quantum communication and computing.
LiverZap: a chemoptogenetic tool for global and locally restricted hepatocyte ablation to study cellular behaviours in liver regeneration
Authors: Ambrosio Elizabeth M. G. , Bailey Charlotte S. L. , Unterweger Iris A. , Christensen Jens B. , Bruchez Marcel P. , Lundegaard Pia R. , Ober Elke A. 
Published: February 2024

ABSTRACT
The liver restores its mass and architecture after injury. Yet, investigating morphogenetic cell behaviours and signals that repair tissue architecture at high spatiotemporal resolution remains challenging. We developed LiverZap, a tuneable chemoptogenetic liver injury model in zebrafish. LiverZap employs the formation of a binary FAP-TAP photosensitiser followed by brief near-infrared illumination inducing hepatocyte-specific death and recapitulating mammalian liver injury types. The tool enables local hepatocyte ablation and extended live imaging capturing regenerative cell behaviours, which is crucial for studying cellular interactions at the interface of healthy and damaged tissue. Applying LiverZap, we show that targeted hepatocyte ablation in a small region of interest is sufficient to trigger local liver progenitor-like cell (LPC)-mediated regeneration, challenging the current understanding of liver regeneration. Surprisingly, the LPC response is also elicited in adjacent uninjured tissue, at up to 100 µm distance to the injury. Moreover, dynamic biliary network rearrangement suggests active cell movements from uninjured tissue in response to substantial hepatocyte loss as an integral step of LPC-mediated liver regeneration. This precisely targetable liver cell ablation tool will enable the discovery of key molecular and morphogenetic regeneration paradigms.
Thrust production and chordal flexion of the flukes of bottlenose dolphins performing tail stands at different efforts
Authors: Kramer David A. , Sheehan Maura J. , Fish Frank E. 
Published: February 2024

ABSTRACT
Dolphins have become famous for their ability to perform a wide variety of athletic and acrobatic behaviors including high-speed swimming, maneuverability, porpoising and tail stands. Tail stands are a behavior where part of the body is held vertically above the water's surface, achieved through thrust produced by horizontal tail fluke oscillations. Strong, efficient propulsors are needed to generate the force required to support the dolphin's body weight, exhibiting chordwise and spanwise flexibility throughout the stroke cycle. To determine how thrust production, fluke flexibility and tail stroke kinematics vary with effort, six adult bottlenose dolphins (Tursiops truncatus) were tested at three different levels based on the position of the center of mass (COM) relative to the water's surface: low (COM below surface), medium (COM at surface) and high (COM above surface) effort. Additionally, fluke flexibility was measured as a flex index (FI=chord length/camber length) at four points in the stroke cycle: center stroke up (CU), extreme top of stroke (ET), center stroke down (CD) and extreme bottom of stroke (EB). Video recordings were analyzed to determine the weight supported above the water (thrust production), peak-to-peak amplitude, stroke frequency and FI. Force production increased with low, medium and high efforts, respectively. Stroke frequency also increased with increased effort. Amplitude remained constant with a mean 33.8% of body length. Significant differences were seen in the FI during the stroke cycle. Changes in FI and stroke frequency allowed for increased force production with effort, and the peak-to-peak amplitude was higher compared with that for horizontal swimming.
Do Employee Interests Affect Target Board Decisions About Acquisition Offers? Evidence from Changes in Unemployment Insurance
Authors: Guo Lixiong , Kong Jing , Masulis Ronald W. 
Published: February 2024

We explore whether employee interests affect the evaluation of acquisition offers by target boards of directors. Exploiting changes in state unemployment insurance (UI) as sources of exogenous variation in worker unemployment costs, we find that lower unemployment costs increase acquisition activity. The adoption of state constituency statutes strengthens this relation. Boards of target firms having high labor intensity, low short-term institutional ownership, headquartered in low population or high social capital counties, and with female independent directors, more often strongly weight employee interests. Higher UI levels are also associated with larger postacquisition layoffs. Our evidence supports theories rationalizing target boards’ consideration of employee interests. This paper was accepted by Victoria Ivashina, finance. Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2022.01379 .
Your Ancestors Worked Hard for this Legitimacy! Theory and Experiment on the Inauthenticity of Second Movers
Authors: Ha Jaekyung , Grodal Stine , Zuckerman Sivan Ezra W. 
Published: February 2024

Why do first movers into a new industry sometimes gain an advantage simply because of the fact that they are perceived by audiences to be more authentic than second movers, whereas in other contexts such second movers are perceived as no less authentic than first movers? We theorize that this difference hinges on the amount of costly, risky “legitimation work” that entrants are perceived to have conducted in their efforts to establish that the new organizational form is reliable and acceptable. Whereas a first mover must expend great effort to reassure skeptical audiences that the new form coheres with their norms and that it can meet and even exceed their standards, later arrivals are often able to appropriate such legitimacy once it has been established. But such appropriation by the second mover makes its (often implicit) claim of original insight or vision seem less authentic than that of the first mover. In three complementary online experiments on audience reactions to online healthcare startups, we find support for our prediction that followers suffer from a lower consumer preference because they are perceived to have done less work in establishing the new form’s legitimacy. Our results show that when follower firms show evidence of participation in legitimation work, it may overturn the default interpretation and reduce the authenticity discount. Supplemental Material: The online appendix is available at https://doi.org/10.1287/orsc.2022.17215 .
Narrowband terahertz generation in a plane-parallel Rb:KTP crystal using a phase mask
Authors: Avetisyan Yuri H. , Makaryan Armen H. 
Published: February 2024

A scheme for efficient generation of multi-cycle terahertz pulses by optical rectification in an artificial periodically poled rubidium (Rb)-doped potassium titanyl phosphate (Rb:PPKTP) structure is proposed. The structure consists of a multi-slit phase mask placed in front of a large-aperture Rb:KTP crystal. The developed theory predicts the THz pulse energy of 343 µJ and the efficiency of the pump-to-terahertz conversion of 0.44% for pump pulse peak intensity of 70GW/cm2 inside an aperture of 9.4×15mm2 at a crystal temperature of 85 K. The opportunity to control the THz spectral bandwidth (in the range of 1.8%∼85%) and frequency of the generation (from 0.3 to 0.8 THz) is shown. The results of the study indicate the high potential of the artificial Rb:PPKTP structure for tunable high-energy THz generation.
Adverse events associated with the delivery of telerehabilitation: A scoping review protocol
Authors: Yau Thomas , McIntyre McKyla , Chan Josh , Bhogal Damanveer , Andreoli Angie , Bayley Mark , Leochico Carl Froilan D. , Kua Ailene , Guo Meiqi , Munce Sarah 
Published: February 2024

Objective
This scoping review aims to map the existing research on adverse events during the delivery of telerehabilitation.

Introduction
Telerehabilitation, a subset of telemedicine, has gained traction during the COVID-19 pandemic as a means to deliver rehabilitation services remotely. However, there exists a research gap as there has yet to be any scoping review, systematic review, or meta-analysis published to identify and summarize the current primary research on adverse events related to telerehabilitation as a whole. It is important to understand how adverse events, such as falls during physiotherapy or aspiration pneumonia during speech language pathology sessions, are associated with telerehabilitation delivery. This will help to identify key limitations for optimizing telerehabilitation delivery by allowing for the development of key risk-mitigation measures and quality indicators. It can also help improve the uptake of telerehabilitation among clinicians and patients. This review aims to fill this research gap by conducting a search of published literature on adverse events in telerehabilitation. Anticipated key findings of this scoping review include identifying the characteristics and frequencies of adverse events during telerehabilitation, the patient populations and types of telerehabilitation associated with the most adverse events, and the quality of reporting of adverse events.

Methods
The review follows the Joanna Briggs Institute (JBI) methodological framework and adheres to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR) guidelines. The review protocol has been registered and published on Open Science Framework. A comprehensive search strategy was implemented across multiple databases (MEDLINE ALL, EMBASE, APA PsycINFO, CENTRAL, and CINAHL). All stages (screening, extraction, and synthesis) will be conducted in duplicate and independently, with data extraction following the TIDieR framework, along with authors, year of publication (before or after COVID), population and sample size, and specific mode/s of telerehabilitation delivery. For synthesis, data will be summarized quantitatively using numerical counts and qualitatively via content analysis. The data will be grouped by intervention type and by type of adverse event.

Inclusion Criteria
This scoping review will include qualitative and quantitative studies published between 2013 and 2023, written in English, and conducted in any geographic area. All modes of telerehabilitation delivery (asynchronous, synchronous, or hybrid) will be included. Systematic reviews, meta-analyses, commentaries, protocols, opinion pieces, conference abstracts, and case series with fewer than five participants will be excluded.
Lung impedance changes during awake prone positioning in COVID-19. A non-randomized cross-over study
Authors: Rosén Jacob , Frykholm Peter , Jonsson Fagerlund Malin , Pellegrini Mariangela , Campoccia Jalde Francesca , von Oelreich Erik , Fors Diddi 
Published: February 2024

Background
The effects of awake prone positioning (APP) on respiratory mechanics in patients with COVID-19 are not well characterized. The aim of this study was to investigate changes of global and regional lung volumes during APP compared with the supine position using electrical lung impedance tomography (EIT) in patients with hypoxemic respiratory failure due to COVID-19.

Materials and methods
This exploratory non-randomized cross-over study was conducted at two university hospitals in Sweden between January and May 2021. Patients admitted to the intensive care unit with confirmed COVID-19, an arterial cannula in place, a PaO2/FiO2 ratio <26.6 kPa (<200 mmHg) and high-flow nasal oxygen or non-invasive ventilation were eligible for inclusion. EIT-data were recorded at supine baseline, at 30 and 60 minutes after APP-initiation, and 30 minutes after supine repositioning. The primary outcomes were changes in global and regional tidal impedance variation (TIV), center of ventilation (CoV), global and regional delta end-expiratory lung-impedance (dEELI) and global inhomogeneity (GI) index at the end of APP compared with supine baseline. Data were reported as median (IQR).

Results
All patients (n = 10) were male and age was 64 (47–73) years. There were no changes in global or regional TIV, CoV or GI-index during the intervention. dEELI increased from supine reference value 0 to 1.51 (0.32–3.62) 60 minutes after APP (median difference 1.51 (95% CI 0.19–5.16), p = 0.04) and returned to near baseline values after supine repositioning. Seven patients (70%) showed an increase >0.20 in dEELI during APP. The other EIT-variables did not change during APP compared with baseline.

Conclusion
Awake prone positioning was associated with a transient lung recruiting effect without changes in ventilation distribution measured with EIT in patients with hypoxemic respiratory failure due to COVID-19.
Indigenous Media Activism in Argentina, Francesca Belotti (2022)
Authors: Ramos-Rodríguez José Manuel 
Published: February 2024

Review of: Indigenous Media Activism in Argentina, Francesca Belotti (2022)
New York: Routledge, 124 pp.,
ISBN 978-1-03215-183-0, h/bk, AUD 103.00
ISBN 978-1-00324-308-3, e-book, AUD 39.59
A női emlékezés mikorrhizás hálózata Suzanne Simard A bölcs erdő titkai (2022) című memoárjában
Authors: Federmayer Éva 
Published: February 2024

Tanulmányomban – a szerző bemutatását és kutatási területének felvázolását követően – Simard visszaemlékezésének narratív dinamikáját olyan szövegként értelmezem, amely a kreatív tényirodalomnak nevezett retorikai térben, több kifejezési forma metszéspontjában, női fejlődéstörténetbe ágyazódó memoárként konstruálódik. Simard narratíváját eképpen – magyar szakirodalmi terminussal élve – „kisparaszti szálalógazdálkodást” folytató, kanadai telepes családból származó kislány tudósnővé formálódásának rögzített nézőpontú, sorsesemények által kikényszerített helyesbítések történeteként olvasom. Elemzésemben igyekszem rávilágítani arra, hogy miként viszonyul a memoár edőökológus elbeszélője a számára rendelkezésre álló nyelvhez, mellyel a humán világ és a nem-humán világ közti kontaktzóna mikorrhizás jelentőségéről nagyközönségéhez szólni kíván. Végül a memoár látszólag „visszaantropomorfizáló” anyafa metaforáját és annak vélt esszencializmusát veszem szemügyre a poszthumanizmus és az ökofeminizmus szakirodalmi kontextusában.