bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanical properties and thermal stability of high-temperature (cooking temperature)-resistant PP/HDPE/POE composites
Authors: Ma Yulong , Yang Kang , Zhang Yi , Wang Juheng , Zeng Shu , Huang Xiaoxiao 
Published: April 2024

Abstract
The heterogeneous nucleation process of polypropylene (PP)/high density polyethylene (HDPE)/thermoplastic elastomer (POE) composites was realized through blending modification, and characterization techniques, including scanning electron microscopy, differential scanning calorimetry, X-ray diffraction, and dynamic mechanical analysis, were used to analyze the pattern of the impact of modified dicyclohexyl-terephthalamide (TMB-5) on the mechanical properties and thermal stability of the PP/HDPE/POE composites. The results indicated that the modified TMB-5 was advantageous to the improvement of the mechanical properties and thermal stability of the high-temperature (cooking temperature)-resistant PP/HDPE/POE composites. When the amount of added modified TMB-5 was 0.4%, the impact strength and tensile strength of the PP/HDPE/POE composites increased to 36.3 kJ/m2 and 31.7 MPa, respectively, which were, respectively, 99.5% and 8.5% higher than those of the materials prepared when the amount of added modified TMB was 0.1%. The materials had higher storage modulus in room-temperature and high-temperature environments: 2,438.2 MPa (room temperature), 1,103.9 MPa (120°C), and 1,054.8 MPa (140°C). In addition, the capability of the PP/HDPE/POE composites to crystallize was improved continuously, and the crystallinity increased considerably. At the same time, the crystallization and melting temperatures increased, β-crystal formation was induced, and glass transition temperature increased, thus effectively improving the mechanical properties and thermal stability of the high-temperature (cooking temperature)-resistant PP/HDPE/POE composites.
Temperature-dependent development and life tables of Palpita unionalis (Lepidoptera: Pyralidae)
Authors: Mansour Amany 
Published: April 2024

Abstract

Palpita unionalis Hubner (Lepidoptera: Pyralidae) is one of the primary pests in olive orchards, damaging buds and fruits of the olive tree. The present study investigated the biology of P. unionalis across a temperature gradient and elaborated on the corresponding life tables for a better understanding of its population dynamics in the environment. The biology of the pest was studied at six temperatures (17, 20, 22, 25, 27, and 30 °C). The duration and survival of immature stages, sex ratio, and survival of emerged adults were evaluated. The female fecundity and longevity (pre-oviposition, oviposition, and post-oviposition periods) were calculated. The life tables were elaborated from these parameters. The life cycle of P. unionalis was significantly longer at 17 °C and shorter at 30 °C. Larval survival was significantly reduced at 30 °C, however, adult survival was at a maximum, yet their sex ratio was not affected by temperature. The lower temperature, 20 °C, was optimal for fecundity (586.3 eggs), which was reflected in the highest net reproductive rate (105.7 offspring per individual). The thermal constant (K) and the lower thermal threshold (t
0) for egg to adult period were 582.9 degree days and 7.1 °C, respectively. Based on the current study, it is concluded from the parameters of biology and life tables that temperature has a significant role in the population growth of P. unionalis. This should be considered throughout the monitoring and management of P. unionalis at different agro-ecologies in the context of global warming.
Trajectory of the body mass index of children and adolescents attending a reference mental health center
Authors: Echeveste-Navarrete Juliana , Zavaleta-Ramírez Patricia , Castilla-Peon Maria Fernanda 
Published: April 2024

Abstract

Objectives
The primary objective was to describe the standardized body mass index (z-BMI) trajectory of children and adolescents admitted to a psychiatric reference center in Mexico City according to their diagnosis and medication use. The secondary objective was to compare z-BMI between antipsychotic users and non-users.

Methods
This is a retrospective cohort study. The psychiatric diagnosis, prescribed medications, serial heights, and weights were collected from the medical records.

Results
The median baseline z-BMI of the 129 analyzed cases was 0.88 (interquartile range [IQR]: 0–1.92), and the prevalence of excessive weight (obesity or overweight) was 46.8 %. At the end of follow-up (median 50.3 weeks), the median change in z-BMI was −0.09 (IQR: −0.68 to 0.42). New long-term users of antipsychotics (n=29) had an increase in their z-BMI, in contrast to never-users (median difference 0.73, p=0.01) and to previous users (median difference 0.92, p=0.047). The 59 subjects with excessive weight at admission had a median z-BMI change of −0.39 (IQR: −0.81 to −0.04). Among patients with excessive weight and depression, there was a greater decrease in z-BMI in sertraline users (n=13) compared with fluoxetine users (n=15) (median −0.65 vs. 0.21, p<0.001).

Conclusions
New long-term users of antipsychotics showed a significant increase in their z-BMI. Patients with depressive disorders and obesity on sertraline therapy tended to show a decrease in their z-BMI.
Concept and feasibility of the Augsburg Longitudinal Plasma Study (ALPS) – a prospective trial for comprehensive liquid biopsy-based longitudinal monitoring of solid cancer patients
Authors: Sommer Sebastian , Schmutz Maximilian , Hildebrand Kathrin , Schiwitza Annett , Benedikt Selinah , Eberle Maria , Mögele Tatiana , Sultan Aziz , Reichl Lena , Campillo Maria , Uhrmacher Luise , Nikolic Ana Antic , Bundschuh Ralph , Lapa Constantin , Kuhlen Michaela , Dintner Sebastian , Langer Angela , Märkl Bruno , Wendler Thomas , Tehlan Kartikay , Kröncke Thomas , Wahle Maria , Mann Matthias , Casadei Nicolas , Pogoda Michaela , Hummler Simone , Sax Irmengard , Schlesner Matthias , Kubuschok Boris , Trepel Martin , Claus Rainer 
Published: April 2024

Abstract

Objectives
Liquid biopsy (LBx) provides diagnostic, prognostic and predictive insights for malignant diseases and offers promising applications regarding tumor burden, tumor heterogeneity and clonal evolution.

Methods
The Augsburg Longitudinal Plasma Study (ALPS) is a prospective trial for patients with metastatic cancer that comprises sequential collection of LBx samples, tumor tissue, radiological imaging data, clinical information and patient-reported outcomes. Peripheral blood plasma is collected based on the individual patient’s staging intervals and LBx-derived ctDNA analyses are performed using CAncer Personalized Profiling sequencing (CAPP-seq).

Results
From April 2021 to October 2023, 419 patients have been enrolled. A total of 1,293 LBx samples were collected, 419 samples (100 %) at the beginning of the study and an average of 3 (range 1–12) during the 30-month follow-up period of the current interim analysis. 380 tissue biopsy (TBx) samples (90.7 %) were available at baseline and 39.6 % had ≥1 TBx samples at follow-up. Lung cancer patients are most prevalent in ALPS (n=147), followed by colorectal (n=38), prostate (n=31) and gastroesophageal cancer (n=28). On average, 12.0 ng/mL plasma cell-free DNA (cfDNA) could be isolated. First CAPP-seq analyses in 60 patients comprised 110 samples and demonstrated a detection sensitivity of 0.1 %.

Conclusions
The first interim analysis of ALPS confirms feasibility for comprehensive longitudinal evaluation of LBx and demonstrates suitability for ctDNA evaluation.
Modeling credit risk with mixed fractional Brownian motion: An application to barrier options
Authors: Hussain Javed , Ali Munawar 
Published: April 2024

Abstract
This article aims to examine the pricing of debt and equity in the context of credit risk structural models, where the value of a company’s assets is influenced by mixed fractional Brownian motion. Three distinct scenarios are analyzed, including when the assets are trade-able, fixed, and subject to partial recovery of debt. The study culminates with the evaluation of debt pricing under the barrier model, where a bankruptcy threshold is established for the company’s asset value.
Liquid biopsy as a new era in endometrial cancer
Authors: Zhuri Drenushe , Yalcintepe Sinem 
Published: April 2024

Abstract
Endometrial cancer (EC) is one of the most frequent invasive cancers of the female genital tract, and despite the rising incidence of EC worldwide and the poor overall survival of patients, no viable blood-based biomarker exists to detect and track EC recurrence during routine follow-up. Identification of new genetic targets and biomarkers linked to enhanced recurrence risk and medication response is a primary clinical issue in the treatment of advanced endometrial cancer. In this regard, liquid biopsy has become a breakthrough in human cancers. A liquid biopsy blood test has the advantage of being more sensitive than traditional imaging and is a minimally invasive complement to needle or excision biopsies of tissue. Here in this article, we discussed the advances and limitations of liquid biopsy. The detection of biomarkers and variations in liquid biopsy may help the diagnostic process of endometrial cancer cases.
In silico modified UV spectrophotometric approaches to resolve overlapped spectra for quality control of rosuvastatin and teneligliptin formulation
Authors: Attimarad Mahesh , Venugopala Katharigatta Narayanaswamy , Nair Anroop B. , Aldhubiab Bandar , Nagaraja Sreeharsha 
Published: April 2024

Abstract
A binary blend of rosuvastatin (ROS) and teneligliptin (TEN) used for the management of cardiovascular complications require a simple, analytical process for the quality assurance of this formulation. UV absorption spectra of ROS and TEN showed overlapping spectra. Hence, the overlapped spectra of ROS and TEN were separated by ratio difference, ratio first derivative; constant extraction coupled with exponentiation with division spectrum, and induced dual-wavelength methods. The proposed methods were authenticated by following the international council for harmonization criteria. A good linear relationship was demonstrated by all four methods, in 2–15 and 2–30 µg/mL for ROS and TEN, respectively. The high percentage retrieval of 98.96–100.22 and 98.72–99.73% for ROS and TEN, respectively, with small relative error, assured the correctness of the techniques. The validated techniques were employed for concurrent evaluation of ROS and TEN from binary formulation and laboratory-prepared mixture. The standard addition process verified the reliability of the projected procedures. The developed methods showed same accuracy and precision when compared to the HPLC methods along with safer solvent. Finally, the environmental sustainability of the presented UV spectroscopic procedures was found to be better than the reported HPLC method. Hence, eco-friendly, simple, and accurate mathematically processed UV spectroscopic procedures can be employed for simultaneous quantification of ROS and TEN for routine quality control study.
Resveratrol modulates signalling to inhibit vascular smooth muscle cell proliferation induced by angiotensin II and high glucose
Authors: Çetin Arzu , Kırça Mustafa , Yeşilkaya Akın 
Published: April 2024

Abstract

Objectives
The proliferation of vascular smooth muscle cells (VSMCs) induced by hyperglycemia plays a pivotal role in the development of atherosclerosis and restenosis. This study aims to examine the impact of angiotensin II (Ang II) and high glucose on VSMC proliferation and the phosphorylation status of key signalling proteins, specifically ERK1/2, Akt, and STAT3. Furthermore, we assess the inhibitory effects of resveratrol, a polyphenolic compound, on these signalling pathways.

Methods
Primary vascular smooth muscle cells (VSMCs) isolated from rat aortas were cultured in both standard media (SM: 5.5 mM) and high glucose media (HGM: 25 mM) and then treated with Ang II (100 nM). Proliferation was assessed using the WST-1 assay, and protein analysis was performed through immunoblotting.

Results
Ang II increased VSMC proliferation by 39 % in standard glucose environments and 17 % in high glucose environments. Resveratrol effectively suppressed Ang II-induced VSMC proliferation in both media. Furthermore, resveratrol inhibited the phosphorylation of ERK1/2 and Akt. Ang II also induced STAT3 phosphorylation by 29 and 18.5 % in SM and HGM, respectively. However, resveratrol treatment reduced STAT3 phosphorylation to control levels.

Conclusions
These findings demonstrated that resveratrol reduces VSMC proliferation induced by Ang II and high glucose conditions, exerting its inhibitory effects by suppressing ERK1/2, Akt, and STAT3 phosphorylation. These results provide valuable insights into the cardioprotective properties of resveratrol.
Investigating the anti-cancer compounds from Calliandra harrisii for precision medicine in pancreatic cancer via in-silico drug design and GC-MS analysis
Authors: Naveed Muhammad , Ali Imran , Aziz Tariq , Javed Khushbakht , Saleem Ayesha , Hanif Nimra , Alharbi Metab 
Published: April 2024

Abstract
Pancreatic cancer is a fatal illness caused by mutations in multiple genes. Pancreatic cancer damages the organ that helps in digestion, resulting in symptoms including fatigue, bloating, and nausea. The use of medicinal plants has been crucial in the treatment of numerous disorders. The medicinal plant Calliandra Harrisi has been widely exploited for its possibilities in biology and medicine. The current study aimed to assess the biopotential of biologically active substances against pancreatic cancer. The GC-MS data of these phytochemicals from Calliandra Harrisi were further subjected to computational approaches with pancreatic cancer genes to evaluate their potential as therapeutic candidates. Molecular docking analysis revealed that N-[Carboxymethyl] maleamic acid is the leading molecule responsible for protein denaturation inhibition, having the highest binding affinity of 6.8 kJ/mol among all other compounds with KRAS inflammatory proteins. Furthermore, ADMET analysis and Lipinski’s rule validation were also performed revealing its higher absorption in the gastrointestinal tract. The results of the hepatotoxicity test demonstrated that phytochemicals are non-toxic, safe to use, and do not cause necrosis, fibrosis, or vacuolar degeneration even at excessive levels. Calliandra Harrisi has phytoconstituents that have a variety of pharmacological uses in consideration.
Predictors of radioiodine (RAI)-avidity restoration for NTRK fusion-positive RAI-resistant metastatic thyroid cancers
Authors: Syed Abdul Rehman , Gorana Aakash , Nohr Erik , Yuan Xiaoli-Kat , Amin MASc Parthiv , Ghaznavi Sana , Lamb Debbie , McIntyre John , Eszlinger Markus , Paschke Ralf 
Published: April 2024

Context
Two-thirds of metastatic differentiated thyroid cancer (DTC) patients have radioiodine (RAI)-resistant disease, resulting in poor prognosis and high mortality. For rare NTRK and RET fusion-positive metastatic, RAI-resistant thyroid cancers, variable success of re-induction of RAI avidity during treatment with NTRK or RET inhibitors has been reported.

Case presentation and results
We report two cases with RAI-resistant lung metastases treated with larotrectinib: an 83-year-old male presenting with an ETV6::NTRK3 fusion-positive tumor with the TERT promoter mutation c.-124C>T, and a 31-year-old female presenting with a TPR::NTRK1 fusion-positive tumor (and negative for TERT promoter mutation). Post larotrectinib treatment, diagnostic I-123 whole body scan revealed unsuccessful RAI-uptake re-induction in the TERT-positive tumor, with a thyroid differentiation score (TDS) of −0.287. In contrast, the TERT-negative tumor exhibited successful I-131 reuptake with a TDS of −0.060.

Conclusion
As observed for RAI-resistance associated with concurrent TERT and BRAF mutations, the co-occurrence of TERT mutations and NTRK fusions may also contribute to re-sensitization failure.
Self-Medication using Chlorpheniramine Maleate in Karanganyar Regency, Central Java, Indonesia
Authors: Fathoni Rifqilya Nurul , Ebtavanny Tamara Gusti , Yunita Ema Pristi 
Published: April 2024

Self-medication refers to the use of medications by a person without consulting health professionals and prescription. One of the common drugs used for self-medication is chlorpheniramine maleate (CTM), a drug indicated to relieve symptoms of allergy. However, the lack of knowledge about the indications of CTM leads to its significant misuse. Long-term effects of CTM misuse include heart rate regularity disorder, central nervous system disorders, and even coma. The purpose of this study was to analyze the correlation between sociodemographic factors and the appropriateness of CTM use for self-medication from the perspective of the experience of using CTM for self-medication. This cross-sectional study was performed in Karanganyar Regency, Central Java, Indonesia, from October to November 2022 on 117 respondents sampled randomly using cluster sampling method. A questionnaire that was already proven as valid and reliable was used. Results for the appropriateness of CTM use showed that 95.7% of respondents were in good category, 3.4% were in fair category, and 0.9% were in poor category. The hypothesis tests, which were the Somers’d test and the contingency coefficient, showed no correlation between age (p=0.242), gender (p=0.307), income level (p=0.789), experience (p=0.176), and the appropriate use of CTM for self-medication. However, there is a correlation between education level (p=0.048) and the appropriate use of CTM for self-medication, albeit very weak (r=0.065). Therefore, only the level of education affects the appropriate use of CTM for self-medication.
Palynotaxonomy of the genus Gladiolus (Iridaceae) of the flora of Armenia
Authors: Hayrapetyan A. M. , Muradyan A. H. , Sonyan H. H. , Asatryan M. Y. , Oganesian M. E. 
Published: April 2024

The genus Gladiolus L. (Iridaceae) includes about 250–280 species of perennial herbaceous corms, distributed in Africa, Madagascar and Eurasia. The taxonomy of the genus is not simple, since the characteristics of the species are quite confusing. Our article presents the results of a comparative palyno-morphological analysis of all 9 species and 2 subspecies of the genus Gladiolus of the Armenian flora. The purpose of the work is to identify diagnostic characteristics of pollen used to distinguish individual taxa. Six morphological characters, namely the length of the polar axis (P), as well as the length of the large and small equatorial diameters (E1 and E2, respectively), exine thickness and the number of echinae and perforations per unit area of the pollen surface were measured using light microscopy (LM) and scanning electron microscopy (SEM). Literature data, as well as the results of our previous studies, showed that the genus is characterized by stenopalynous anasulcate pollen grains with a two-lane operculum. In the presence of significant uniformity in pollen characteristics, our studies revealed that among the species studied, G. hajastanicus and G. kotschyanus have slightly larger pollen grain sizes, and the pollen of the species G. tenuis is characterized by a minimal number of both echinae and perforations per unit surface area of the pollen grain (using SEM). A certain difference has also been established between the subspecies of the species G. kotschyanus. In particular, the sizes of pollen grains of G. kotschyanus subsp. kotschyanus (based on E1) is slightly larger than in G. kotschyanus subsp. distichus. At the same time, the number of echinae and perforations per unit surface of a pollen grain (at the SEM level) in the subspecies G. kotschyanus subsp. distichus is approximately twice as large as G. kotschyanus subsp. kotschianus.
Assessing the effect of glyphosate on the shrimp Palaemon adspersus: Acute toxicity and biomarker responses
Authors: Hamoudi F. S. , Berghiche H. , Chouahda S. 
Published: April 2024

Glyphosate, a widely used agricultural herbicide, poses a risk of aquatic contamination. This study assessed the acute toxicity of glyphosate in the shrimp Palaemon adspersus (Decapoda, Palaemonidae). The sublethal (LC10 and LC25) and lethal (LC50 and LC90) concentrations were estimated after 24 and 96 hours of exposure. The compound was added to rearing water at LC25 and LC50– for 96 hours during the exposure phase (24, 48, 72, and 96 hours). Shrimp were then transferred to clean seawater and collected during the recovery phase (24, 48, 72, and 96 hours). Enzymatic activities in shrimp heads and flesh fragments were measured for acetylcholinesterase, gluthatione S-transferase, and malondialdehyde, followed by lipid quantification. Toxicological data indicated the toxicity of glyphosate against shrimp, exhibiting a dose-response effect. Lethal concentrations LC10, 25, 50, 90 were 1.15, 1.25, 1.35, 1.59 mg/L after 24 hours and 0.99, 1.06, 1.14, 1.31 mg/L after 96 hours. Two-way ANOVA during the treatment phase showed significant (P < 0.05) effects of glyphosate concentration and treatment time on all the biomarkers. During the recovery phase, shrimp compensated for herbicide effects, demonstrating acute toxicity that caused oxidative stress and neurotoxic effects at sublethal concentrations. Careful control is recommended to minimise the negative impacts on non-target aquatic organisms.
Distribution of non-marine ostracods in the streams of the Ceyhan River Basin (Turkey) and assessment of their indicator properties for water quality
Authors: Yavuzatmaca Mehmet , Çelekli Abuzer , Dügel Muzaffer , Lekesiz Ömer 
Published: April 2024

AbstractThe potential of ostracod species as indicators of water quality and the influence of key ecological parameters on their distribution were evaluated by collecting samples from 39 streams during the spring, summer, and autumn seasons. Thirty-seven ostracod taxa (23 living, 14 subfossil) were identified, with Hemicypris anomala (Klie, 1938) being newly reported for Turkey. The summer season exhibited the highest diversity, indicated by the highest Shannon index value of 2.119, while the spring season showed the lowest diversity with a Shannon index value of 1.673. The variability in species composition was greater in the autumn than in other seasons. Among the nine factors affecting species distribution, the first three were found to be total nitrogen, magnesium, and elevation. Ilyocypris decipiens Masi, 1905 and Stenocypris intermedia Klie, 1932 indicated medium water quality in relation to the electrical conductivity, dissolved oxygen, total nitrogen and phosphorus. Stenocypris intermedia depicted waters of medium quality for biological oxygen demand and poor quality for nitrate. Ilyocypris monstrifica (Norman, 1862) signaled waters of good quality for total nitrogen and medium quality for dissolved oxygen. Potamocypris fallax Fox, 1967 and Potamocypris similis G.W. Müller, 1912 characterized good and medium water quality regarding dissolved oxygen and total phosphorus, respectively. Cypridopsis vidua (O.F. Müller, 1776) was identified as a positive-pollution indicator related to ammonium. The results suggest that ostracods have great potential as indicators of water quality, but more detailed studies on water quality parameters and ostracods are needed.