bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evidence for linkage of red blood cell size and count: Genome‐wide scans in the Framingham Heart Study
Authors: Lin Jing‐Ping , O'Donnell Christopher J. , Jin Li , Fox Caroline , Yang Qiong , Cupples L. Adrienne 
Published: January 2007

AbstractRed blood cell (RBC) count and size are major criteria for evaluating anemia and related hematology disease diagnoses. While environmental factors influence RBC count (RBCC) and size, mean corpuscular volume (MCV), and mean corpuscular hemoglobin (MCH), studies have indicated that each of these measures has a substantial genetic component. So far, no linkage analysis or genome scan has been reported. We carried out 10 cM genome‐wide scans on RBCC, MCV, and MCH in a community‐based Caucasian cohort, the Framingham Heart Study, using 325 pedigrees with 1,144 individuals genotyped and phenotyped. Using variance‐component linkage methods, heritabilities were estimated as 56, 52, and 52% after covariate adjusted for RBCC, MCV, and MCH, respectively. For RBCC, we found a maximum LOD score of 3.2 on chromosome 19, 24 cM (7.0 Mbp). Near this region, there lie a few important candidate genes, including erythropoietin receptor and erythroid Krüppel‐like factor. For linkage analyses for MCV and MCH, there were coinciding maximized LOD scores on chromosome 11, 9 cM (5.2 Mbp) with values of 3.8 and 3.6, respectively. Under the peak resides the hemoglobin β cluster ‐ several β‐like genes, which are important candidates for RBC size. In subsequent analyses, we excluded individuals with low MCV to assess the possible influence of β‐thalassemia carriers, and there continued to be evidence for linkage in the same region on chromosome 11p15 (LOD scores of 2.6 and 2.7 for MCV and MCH, respectively). For MCV, we also identified a new region on chromosome 6q24 with a LOD score of 2.9. These findings suggest that further studies are warranted to identify potential causal genetic variants for RBC size and count and related erythrocyte indices. Am. J. Hematol., 2007. Published 2007 Wiley‐Liss, Inc.
Proceeding to yes: A federal judge looks at ADR's future
Authors: Greenaway Jr. Joseph A. 
Published: January 2007

AbstractA CPR News special: Two recent speeches discussing Alternatives' publisher's impact on ADR, and what the future may look like. First, the remarks of 2006 CPR Corporate Leadership Award dinner keynoter Joseph A. Greenaway Jr., a Newark, N.J., U.S. District Court Judge, focus on where ADR works and where its promise lies. CPR Senior Vice President F. Peter Phillips, in addressing the First African ADR Congress in Nigeria in November, provides a history of commercial conflict resolution.
How conflict resolution emerged within the commercial sector
Authors: Phillips F. Peter 
Published: January 2007

AbstractA CPR News special: Two recent speeches discussing Alternatives' publisher's impact on ADR, and what the future may look like. First, the remarks of 2006 CPR Corporate Leadership Award dinner keynoter Joseph A. Greenaway Jr., a Newark, N.J., U.S. District Court Judge, focus on where ADR works and where its promise lies. CPR Senior Vice President F. Peter Phillips, in addressing the First African ADR Congress in Nigeria in November, provides a history of commercial conflict resolution.
Intramolecular phenylborane complexes with monobasic bidentate Schiff bases
Authors: Gaur Shweta , Fahmi Nighat , Agarwal Meera , Singh R. V. 
Published: January 2007

AbstractA series of intramolecular complexes with Schiff base ligands having N∩S and N∩O donor systems were synthesized in an open vessel under microwave irradiation (MWI) using a domestic microwave oven. The reaction time has been brought down from hours to seconds with improved yield as compared with the conventional heating. The complexes have been characterized on the basis of elemental analysis, conductance measurements and spectroscopic analysis. Based on the IR, 1H NMR, 11B NMR and 13C NMR spectroscopic studies, a tetrahedral geometry has been proposed for the resulting complexes. The compounds have been screened in vitro against bacteria and fungi to test their antimicrobial property and in vivo in male albino rats to test their antifertility property. The testicular sperm density, motility and density of cauda epididymal spermatozoa along with biochemical parameters of reproductive organs have been examined and discussed. Copyright © 2007 John Wiley & Sons, Ltd.
The use of microgravity, magnetometry and resistivity surveys for the characterization and preservation of an archaeological site at Umm er‐Rasas, Jordan
Authors: Batayneh A. , Khataibeh J. , Alrshdan H. , Tobasi U. , Al‐Jahed N. 
Published: January 2007

AbstractIn this paper we present the application of microgravity, magnetometry, and electrical resistivity tomography (ERT) methods to an archaeological investigation. The aim of this study was to obtain information about the subsurface and associated buried structures beneath the Late Byzantine ‘Lion Church’, in the ancient town of Umm er‐Rasas. In order to test this site a number of gravity and magnetic stations were carried out on the mosaic floor of the church. Gravity data were collected on a 1‐m grid station along survey lines spaced 1 m apart. Magnetic data were taken at heights of 0.8 m and 1.3 m, at about 10‐cm intervals along the same traverses used in the gravity survey in order to obtain a direct comparison between the two methods. Resistivity measurements were carried out utilizing the Wenner array with 2‐m electrode spacing along profiles spaced 2 m apart close to the church wall in order to investigate water leakage below the church floor.Both microgravity and magnetometry methods found a number of structures with contrasting physical properties to those of the surrounding material. The archaeological interpretation of such structures is in terms of two possible floors of a building with remains of walls, rooms, paths and foundations. Resistivity data based on two‐dimensional‐modelling show a highly conductive region close to the church wall. This is may be attributed to rain water which seeps under the mosaic floor of the church. Copyright © 2007 John Wiley & Sons, Ltd.
DNA bending induced by carbocyclic sugar analogs constrained to the north conformation
Authors: Macias Alba T. , Banavali Nilesh K. , MacKerell Alexander D. 
Published: January 2007

AbstractDNA bending caused by introduction of carbocyclic sugars constrained to the north conformation was studied, using explicit solvent molecular dynamic (MD) simulations. The native Drew–Dickerson (DD) dodecamer and its three modifications containing north carbocyclic sugars in the 7th (T7*), 8th (T8*) or both 7th and 8th (T7T8*) nucleotide positions were examined. Introduction of the carbocyclic sugar results in A‐form conformations for the α, β, χ, ζ, and sugar pucker backbone parameters in the modified nucleotides. Increased steric repulsion between the sugar and its parent base in the modified oligonucleotides impacts the roll and cup dinucleotide step parameters, increasing the bending of the oligomer axis. Increased buckling of the substituted nucleotides disrupts the usual stabilizing base stacking interactions. The level of overall bending depends on the number and position of carbocyclic sugars introduced in the DNA sequence. Single sugar substitutions are unable to induce substantial bending due to the neighboring unmodified nucleotides counterbalancing the distortion. Significant bending can, however, be induced by two consecutive north sugars (T7T8*), which is in agreement with experimental results. The modified oligomers populate a wide range of bend angles, indicating that they maintain flexibility in the bent state. The present results suggest that insertion of carbocyclic sugars into DNA or RNA duplexes can be used to engineer bending of the duplexes without impacting the electrostatic or chemical properties of the phosphodiester backbone, thereby serving as excellent tools for experimental elucidation of nucleic acid structure–function relationships. © 2007 Wiley Periodicals, Inc. Biopolymers 85: 438–449, 2007.This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com
Optimization of a jet‐propelled particle injection system for the uniform transdermal delivery of drug/vaccine
Authors: Liu Yi , Kendall Mark A.F. 
Published: January 2007

AbstractA jet‐propelled particle injection system, the biolistics, has been developed and employed to accelerate micro‐particles for transdermal drug delivery. We have examined a prototype biolistic device employing a converging–diverging supersonic nozzle (CDSN), and found that the micro‐particles were delivered with a wide velocity range (200–800 m/s) and spatial distribution. To provide a controllable system for transdermal drug delivery, we present a contoured shock‐tube (CST) concept and its embodiment device. The CST configuration utilizes a quasi‐steady, quasi‐one dimensional and shock‐free supersonic flow to deliver the micro‐particles with an almost uniform velocity (the mean velocity and the standard deviation, 699 ± 4.7 m/s) and spatial distribution. The transient gas and particle dynamics in both prototype devices are interrogated with the validated computational fluid dynamics (CFD) approach. The predicted results for static pressure and Mach number histories, gas flow structures, particle velocity distributions and gas–particle interactions are presented and interpreted. The implications for clinical uses are discussed. Biotechnol. Bioeng. 2007; 97: 1300–1308. © 2007 Wiley Periodicals, Inc.
Flow modeling in a novel non‐perfusion conical bioreactor
Authors: Singh Harmeet , Ang Eng Seng , Lim T.T. , Hutmacher Dietmar W. 
Published: January 2007

AbstractWe have developed a bioreactor vessel design which has the advantages of simplicity and ease of assembly and disassembly, and with the appropriately determined flow rate, even allows for a scaffold to be suspended freely regardless of its weight. This article reports our experimental and numerical investigations to evaluate the performance of a newly developed non‐perfusion conical bioreactor by visualizing the flow through scaffolds with 45° and 90° fiber lay down patterns. The experiments were conducted at the Reynolds numbers (Re) 121, 170, and 218 based on the local velocity and width of scaffolds. The flow fields were captured using short‐time exposures of 60 µm particles suspended in the bioreactor and illuminated using a thin laser sheet. The effects of scaffold fiber lay down pattern and Reynolds number were obtained and correspondingly compared to results obtained from a computational fluid dynamics (CFD) software package. The objectives of this article are twofold: to investigate the hypothesis that there may be an insufficient exchange of medium within the interior of the scaffold when using our non‐perfusion bioreactor, and second, to compare the flows within and around scaffolds of 45° and 90° fiber lay down patterns. Scaffold porosity was also found to influence flow patterns. It was therefore shown that fluidic transport could be achieved within scaffolds with our bioreactor design, being a non‐perfusion vessel. Fluid velocities were generally same of the same or one order lower in magnitude as compared to the inlet flow velocity. Additionally, the 90° fiber lay down pattern scaffold was found to allow for slightly higher fluid velocities within, as compared to the 45° fiber lay down pattern scaffold. This was due to the architecture and pore arrangement of the 90° fiber lay down pattern scaffold, which allows for fluid to flow directly through (channel‐like flow). Biotechnol. Bioeng. 2007; 97: 1291–1299. © 2007 Wiley Periodicals, Inc.
Elaboration of Neosamine Rings in the Biosynthesis of Neomycin and Butirosin
Authors: Huang Fanglu , Spiteller Dieter , Koorbanally Neil A. , Li Yanyan , Llewellyn Nicholas M. , Spencer Jonathan B. 
Published: January 2007

AbstractThe proteins Neo‐11 and Neo‐18 encoded in the neomycin gene cluster (neo) ofStreptomyces fradiaeNCIMB 8233 have been characterized as glucosaminyl‐6′‐oxidase and 6′‐oxoglucosaminyl:L‐glutamate aminotransferase, respectively. The joint activity of Neo‐11 and Neo‐18 is responsible for the conversion of paromamine to neamine in the biosynthetic pathway of neomycin through a mechanism of FAD‐dependent dehydrogenation followed by a pyridoxal‐5′‐phosphate‐mediated transamination. Neo‐18 is also shown to catalyze deamination at C‐6′′′ of neomycin, thus suggesting bifunctional roles of the two enzymes in the formation of both neosamine rings of neomycin. The product of thebtrBgene, a homologue ofneo‐18in the butirosin biosynthetic gene cluster (btr) inBacillus circulans, exhibits the same activity as Neo‐18; this indicates that there is a similar reaction sequence in both butirosin and neomycin biosynthesis.
Biosynthesis of the 2‐Pyridone Tenellin in the Insect Pathogenic Fungus Beauveria bassiana
Authors: Eley Kirstin L. , Halo Laura M. , Song Zhongshu , Powles Henry , Cox Russell J. , Bailey Andrew M. , Lazarus Colin M. , Simpson Thomas J. 
Published: January 2007

AbstractGenomic DNA from the insect pathogenic fungus Beauveria bassiana was used as a template in a PCR with degenerate primers designed to amplify a fragment of a C‐methyl transferase (CMeT) domain from a highly reduced fungal polyketide synthase (PKS). The resulting 270‐bp PCR product was homologous to other fungal PKS CMeT domains and was used as a probe to isolate a 7.3‐kb fragment of genomic DNA from a BamH1 library. Further library probing and TAIL‐PCR then gave a 21.9‐kb contig that encoded a 12.9‐kb fused type I PKS–NRPS ORF together with ORFs encoding other oxidative and reductive enzymes. A directed knockout experiment with a BaR cassette, reported for the first time in B. bassiana, identified the PKS–NRPS as being involved in the biosynthesis of the 2‐pyridone tenellin. Other fungal PKS–NRPS genes are known to be involved in the formation of tetramic acids in fungi, and it thus appears likely that related compounds are precursors of 2‐pyridones in fungi. B. bassiana tenellin KO and WT strains proved to be equally pathogenic towards insect larvae; this indicated that tenellin is not involved in insect pathogenesis.
An Atomistic MD Simulation and Pair‐Distribution‐Function Study of Disorder and Reactivity of α‐AlF3 Nanoparticles.
Authors: Chaudhuri Santanu , Chupas Peter , Morgan Benjamin J. , Madden Paul A. , Grey Clare P. 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
The New Lead Vanadylphosphate Pb2VO(PO4)2.
Authors: Shpanchenko Roman V. , Kaul Enrique E. , Geibel Christoph , Antipov Evgeny V. 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Layered Oxysulfides Sr2MnO2Cu2m‐0.5Sm+1 (m = 1, 2, and 3) as Insertion Hosts for Li Ion Batteries.
Authors: Indris Sylvio , Cabana Jordi , Rutt Oliver J. , Clarke Simon J. , Grey Clare P. 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
High‐Throughput Synthesis and Catalytic Properties of a Molecular Sieve with 18‐ and 10‐Member Rings.
Authors: Corma Avelino , Diaz‐Cabanas Maria J. , Jorda Jose Luis , Martinez Cristina , Moliner Manuel 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Efficient Preparation and Catalytic Activity of MgO(111) Nanosheets.
Authors: Zhu Kake , Hu Juncheng , Kuebel Christian , Richards Ryan 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis and Structural Characterization of a New Alkaline Earth Imide: MgCa(NH)2.
Authors: Liu Yongfeng , Liu Tao , Xiong Zhitao , Hu Jianjiang , Wu Guotao , Chen Ping , Wee Andrew T. S. , Yang Ping , Murata Kenji , Sakata Ko 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Novel Europium Carbodiimide that Contains Isolated Europium Tetrahedra and Parallel Chains of Edge‐Sharing Open Handbag‐Like Eu6 Units.
Authors: Liao Wuping , Englert Ulli , Dronskowski Richard 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Na2Li8 [(UO2)11O12(WO5)2]: Three Different Uranyl‐Ion Coordination Geometries and Cation—Cation Interactions.
Authors: Alekseev Evgeny V. , Krivovichev Sergey V. , Depmeier Wulf , Siidra Oleg I. , Knorr Karsten , Suleimanov Evgeny V. , Chuprunov Evgeny V. 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Syntheses, Structural Studies, and Magnetic Properties of Divalent Cu and Co Selenites with Organic Constituents.
Authors: Feng Mei‐Ling , Prosvirin Andrey V. , Mao Jiang‐Gao , Dunbar Kim R. 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis, Crystal Structure and Magnetic Properties of Na3OsO5.
Authors: Mogare Kailash M. , Klein Wilhelm , Schilder Helmut , Lueken Heiko , Jansen Martin 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Highly Enantioselective Direct Aldol Reaction Catalyzed by Organic Molecules.
Authors: Raj Monika , Vishnumaya Vishnumaya , Ginotra Sandeep K. , Singh Vinod K. 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of the Bifunctional BINOL Ligands and Their Applications in the Asymmetric Additions to Carbonyl Compounds.
Authors: Qin Ying‐Chuan , Liu Lan , Sabat Michal , Pu Lin 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
The Reaction of Tanshinones with Diamines.
Authors: An Lin‐Kun , Bu Xian‐Zhang , Song Xiao‐Hong , Huang Zhi‐Shua , Liu Pei‐Qing , Gu Lian‐Quan 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Microwave‐Mediated Synthesis of Some Novel Heterocycles Containing Thiazole, Oxazole, Thiazine, Oxazine, Thiadiazine and Triazolo‐thiadiazine Moiety.
Authors: Dabholkar Vijay V. , Mishra Sushil Kumar J. 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of Methyl‐5‐[2‐arylamino‐4‐(3‐oxo‐1,4‐benzoxazin‐6‐yl)thiazole]acetates and 7H‐[3‐Aryl‐6‐(3‐oxo‐1,4‐benzoxazin‐6‐yl)‐s‐triazolo[3,4‐b] [1,3,4]thiadiazin‐7‐yl]acetates as Possible COX‐2‐Inhibitors.
Authors: Reddy G. Jagath , Rao K. Srinivasa , Jayaveera K. N. , Sailaja S. , Reddanna P. , Reddy D. Bharat 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Unexpected Highly Efficient Ring‐Opening of Aziridines or Epoxides with Iodine Promoted by Thiophenol.
Authors: Wu Jie , Sun Xiaoyu , Sun Wei , Ye Shengqing 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
[1,2]‐ or [2,3]‐Rearrangement of Onium Ylides of Allyl and Benzyl Ethers and Sulfides via in situ‐Generated Iodonium Ylides.
Authors: Murphy Graham K. , West F. G. 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Hydrogenation of Ethyl Esters of 4‐Phenyl‐ and (2‐Furyl)‐Substituted 2,4‐Dioxobutyric Acids at Palladium Black.
Authors: Slavinska V. , Sile Dz. , Rozenthal G. , Maurops G. , Popelis J. , Katkevich M. , Stonkus V. , Lukevics E. 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Tetrabromo Hydrogenated Cardanol: Efficient and Renewable Brominating Agent.
Authors: Attanasi Orazio A. , Berretta Stefano , Favi Gianfranco , Filippone Paolino , Mele Giuseppe , Moscatelli Giada , Saladino Raffaele 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Hydrothiolysis of Carbofunctional α,β‐Unsaturated Sulfides as an Approach to the Synthesis of 1,7‐Dithiocarbonyl Compounds.
Authors: Timokhina L. V. , Sokol'nikova O. V. , Kanitskaya L. V. , Yashchenko M. P. , Toryashinova D.‐S. D. , Voronkov M. G. 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Ti(NMe2)4‐Catalyzed Markovnikov Hydroamination of Alkynes in the Presence of N‐Heterocyclic Carbenes and LiN(SiMe3)2.
Authors: Takaki Ken , Koizumi Sadayuki , Yamamoto Yuta , Komeyama Kimihiro 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Palladium‐Catalyzed, Copper(I)‐Mediated Coupling of Boronic Acids and Benzylthiocyanate. A Cyanide‐Free Cyanation of Boronic Acids.
Authors: Zhang Zhihui , Liebeskind Lanny S. 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Practical Knoevenagel Condensation Catalyzed by Imidazole.
Authors: Heravi Majid M. , Tehrani Maryam H. , Bakhtiari Khadijeh , Oskooie Hossein A. 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.