bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proteomic Analyses in Diverse Populations Improved Risk Prediction and Identified New Drug Targets for Type 2 Diabetes
Authors: Yao Pang , Iona Andri , Pozarickij Alfred , Said Saredo , Wright Neil , Lin Kuang , Millwood Iona , Fry Hannah , Kartsonaki Christiana , Mazidi Mohsen , Chen Yiping , Bragg Fiona , Liu Bowen , Yang Ling , Liu Junxi , Avery Daniel , Schmidt Dan , Sun Dianjianyi , Pei Pei , Lv Jun , Yu Canqing , Hill Michael , Bennett Derrick , Walters Robin , Li Liming , Clarke Robert , Du Huaidong , Chen Zhengming ,   China Kadoorie Biobank Collaborative Group
Published: April 2024

OBJECTIVE
Integrated analyses of plasma proteomics and genetic data in prospective studies can help assess the causal relevance of proteins, improve risk prediction, and discover novel protein drug targets for type 2 diabetes (T2D).

RESEARCH DESIGN AND METHODS
We measured plasma levels of 2,923 proteins using Olink Explore among ∼2,000 randomly selected participants from China Kadoorie Biobank (CKB) without prior diabetes at baseline. Cox regression assessed associations of individual protein with incident T2D (n = 92 cases). Proteomic-based risk models were developed with discrimination, calibration, reclassification assessed using area under the curve (AUC), calibration plots, and net reclassification index (NRI), respectively. Two-sample Mendelian randomization (MR) analyses using cis-protein quantitative trait loci identified in a genome-wide association study of CKB and UK Biobank for specific proteins were conducted to assess their causal relevance for T2D, along with colocalization analyses to examine shared causal variants between proteins and T2D.

RESULTS
Overall, 33 proteins were significantly associated (false discovery rate &lt;0.05) with risk of incident T2D, including IGFBP1, GHR, and amylase. The addition of these 33 proteins to a conventional risk prediction model improved AUC from 0.77 (0.73–0.82) to 0.88 (0.85–0.91) and NRI by 38%, with predicted risks well calibrated with observed risks. MR analyses provided support for the causal relevance for T2D of ENTR1, LPL, and PON3, with replication of ENTR1 and LPL in Europeans using different genetic instruments. Moreover, colocalization analyses showed strong evidence (pH4 &gt; 0.6) of shared genetic variants of LPL and PON3 with T2D.

CONCLUSIONS
Proteomic analyses in Chinese adults identified novel associations of multiple proteins with T2D with strong genetic evidence supporting their causal relevance and potential as novel drug targets for prevention and treatment of T2D.
Sustained Effectiveness of an Advanced Hybrid Closed-Loop System in a Cohort of Children and Adolescents With Type 1 Diabetes: A 1-Year Real-World Study
Authors: Passanisi Stefano , Salzano Giuseppina , Bombaci Bruno , Minuto Nicola , Bassi Marta , Bonfanti Riccardo , Scialabba Francesco , Mozzillo Enza , Di Candia Francesca , Monti Sara , Graziani Vanna , Maffeis Claudio , Piona Claudia Anita , Arnaldi Claudia , Tosini Davide , Felappi Barbara , Roppolo Rosalia , Zanfardino Angela , Delvecchio Maurizio , Lo Presti Donatella , Calzi Elena , Ripoli Carlo , Franceschi Roberto , Reinstadler Petra , Rabbone Ivana , Maltoni Giulio , Alibrandi Angela , Zucchini Stefano , Marigliano Marco , Lombardo Fortunato ,   ISPED Diabetes Study Group Collaborators, Grosso Caterina , Cherubini Valentino , Tiberi Valentina , Piccinno Elvira , Zecchino Clara , Prandi Elena , Ricciardi Maria Rossella , Stamati Filomena , Costanza Giuseppe , Pezzino Giulia , Rosaria De Marco , Bratta Anna , Spacco Giordano , Rigamonti Andrea , Frontino Giulio , Predieri Barbara , Iafusco Dario , Rosanio Francesco , Pozzi Erica , Cardella Francesca , Dal Bo Sara , Riso Chiara 
Published: April 2024

OBJECTIVE
To investigate glucose metrics and identify potential predictors of the achievement of glycemic outcomes in children and adolescents during their first 12 months of MiniMed 780G use.

RESEARCH DESIGN AND METHODS
This multicenter, longitudinal, real-world study recruited 368 children and adolescents with type 1 diabetes (T1D) starting SmartGuard technology between June 2020 and June 2022. Ambulatory glucose profile data were collected during a 15-day run-in period (baseline), 2 weeks after automatic mode activation, and every 3 months. The influence of covariates on glycemic outcomes after 1 year of MiniMed 780G use was assessed.

RESULTS
After 15 days of automatic mode use, all glucose metrics improved compared with baseline (P &lt; 0.001), except for time below range (P = 0.113) and coefficient of variation (P = 0.330). After 1 year, time in range (TIR) remained significantly higher than at baseline (75.3% vs. 62.8%, P &lt; 0.001). The mean glycated hemoglobin (HbA1c) over the study duration was lower than the previous year (6.9 ± 0.6% vs. 7.4 ± 0.9%, P &lt; 0.001). Time spent in tight range (70–140 mg/dL) was 51.1%, and the glycemia risk index was 27.6. Higher TIR levels were associated with a reduced number of automatic correction boluses (P &lt; 0.001), fewer SmartGuard exits (P = 0.021), and longer time in automatic mode (P = 0.030). Individuals with baseline HbA1c &gt;8% showed more relevant improvement in TIR levels (from 54.3% to 72.3%).

CONCLUSIONS
Our study highlights the sustained effectiveness of MiniMed 780G among youth with T1D. Findings suggest that even children and adolescents with low therapeutic engagement may benefit from SmartGuard technology.
Reference university teacher
Authors: Воронцов Д.Б. , Голицина С.С. , Ершова М.В. 
Published: April 2024

В научной статье авторы раскрывают вопрос референтности преподавателя для студентов вуза. В работе проанализированы исследования современных ученых по интересующей проблематике, представлены теоретические выводы. Кроме того, в статье охарактеризованы результаты исследования, проведенного на базе Костромского государственного университета. Исследование проводилось посредством опроса (с использованием google-форм) и интервью. На основе результатов теоретического и эмпирического исследования выявлены особенности референтности преподавателя для студентов гуманитарной направленности, а также факторы, влияющие на значимость, сформулированы вопросы для дальнейшего исследования.
In the scientific article, the authors reveal the issue of the teacher’s referentiality for university students. The work analyzes the research of modern scientists on the issues of interest and presents theoretical conclusions. In addition, the article describes the results of a study conducted through a survey (using Google forms) and interviews at Kostroma State University. Based on the results of theoretical and empirical research, the features of the teacher’s referentiality for students of the humanities have been identified, as well as factors influencing the significance, and questions for further research have been raised.
Professionally important values of military personnel undergoing military service under contract in the troops of the National Guard of Russia
Authors: Тепляков С.В. 
Published: April 2024

Актуальность темы статьи обусловлена тем, что в качестве одного из ключевых условий сформированности профессиональных ценностных ориентаций военного специалиста, определяющих его дальнейшее развитие и совершенствование, выступает эффективный отбор и приращение новых профессионально важных ценностей. В статье представлен авторский подход к классификации профессиональных ценностей: по отношению к себе, профессии, другим и стране. Выделение в данной классификации профессионально важных ценностей будет способствовать оптимизации подготовки военных профессионалов в соответствии с современными требованиями, предъявляемыми к ним.
The relevance of the topic of the article is due to the fact that one of the key conditions for the development of professional value orientations of a military specialist, determining his further development and improvement, is the effective selection and increment of new professionally important values. The article presents the author's approach to the classification of professional values: in relation to oneself, profession, other people and country. The author highlights professionally important values in this classification, which will contribute to the training of military professionals in accordance with current requirements.
The role of language and wine images in the development of the artistic space of national culture (based on the lyrics by O. E. Mandelstam)
Authors: Голубева А.А. 
Published: April 2024

Основным мотивом творчества О. Э. Мандельштама является мотив «тоски по мировой культуре». Важными средствами приобщения к культуре для поэта были национальный язык и национальная винная культура. Цель исследования – проанализировать образы языка и вина в поэтических текстах О. Э. Мандельштама, воспроизводящих художественное пространство «чужих» культур. Научная новизна работы связана с использованием лингвокультурологического подхода для интерпретации поэтических образов. Мотивы и способы речевой реализации образов выявляются на примере античной и немецкой культуры при помощи методов описательного, контекстуального и интертекстуального анализа. В результате исследования выясняется, что образы языка и вина в творчестве О. Э. Мандельштама объединяет культурно-атрибутивная функция и вербализация при помощи похожих фонетических и лексических приемов.
The main motive of O. E. Mandelstam's work is the motive of "longing for world culture". The national language and national wine culture were important means for the poet to get acquainted with culture. The purpose of the study is to analyse the images of language and wine in O. E. Mandelstam's poetic texts reproducing the artistic space of alien cultures. The scientific novelty of the work is connected with linguocultural approach taken to the interpretation of poetic images. Motives and speech realisation of images are revealed on the example of ancient and German culture applying methods of descriptive, contextual and intertextual analysis. The study reveals that language and wine images in O. E. Mandelstam's work are united by the cultural-attributive function and verbalisation by means of similar phonetic and lexical techniques.
Elements of postmodern texts in Russian Harry Potter fanfiction
Authors: Петрова Р.Ю. 
Published: April 2024

В статье фанфикшен анализируется как постмодернистский текст. Актуальность статьи основывается на недостаточной изученности фанфикшена с этого ракурса. Материалом для исследования стали рейтинговые фанфики русскоязычного автора Насти Чацкой. Мы обращаем внимание на специфику фанфика как медийного текста эпохи постмодерна. После проведенного анализа становится возможным утверждать, что рассмотренные фанфики обладают признаками постмодернистского художественного текста (используются системы образов из разных литературных жанров, языковая игра, различные группы лексики, как отсылающие к первоисточнику, так и характеризующие стилистику автора).
The article analyses fanfiction as a postmodern text. The relevance of the article is based on the insufficient study of fanfiction from this perspective. The material for the study is the rated fanfics of the Russian author Nastya Chatskaya. The study considers the specificity of fanfic as a media text of the postmodern era. After the analysis, it is possible to state that the fanfics under consideration have the features of a postmodernist fiction text (using systems of images from different literary genres, language game, different lexical groups, both referring to the original source and characterising the author's stylistics)
Code-switching of English Department students in structural, semantic, and pragmatic aspects (Longitudinal approach)
Authors: Чиршева Г.Н. , Беляевская А.А. 
Published: April 2024

В рассматриваемых кодовых переключениях студентов-лингвистов комбинируются единицы русского, английского и немецкого языков. Цель исследования – описать структуру, семантику и прагматику кодовых переключений студентов-лингвистов в лонгитюдном аспекте – на 2-м, 3-м и 4-м курсах. Материал исследования – билингвальные и трилингвальные высказывания (201 единица), которые методом наблюдения и письменной фиксации извлечены из речи студентов-лингвистов в процессе их общения на переменах в университете. Процедура исследования включает качественные и количественные методы анализа. Новизна данной работы состоит в лонгитюдном подходе (на протяжении трех периодов на трех курсах в речевой деятельности одних и тех же студентов) и комплексном анализе (три аспекта) многоязычной речи индивидов в однородных коммуникативных ситуациях. Результаты исследования показали, что самыми частотными структурами в речи студентов на протяжении трех лет являются внутрифразовые переключения (островные и собственно вкрапления), а семантика и прагматика переключений отражают стремление к точному и в то же время экспрессивному и юмористическому отображению учебных объектов и явлений повседневной жизни студентов. Различия во всех трех рассмотренных аспектах на протяжении трех анализируемых периодов были лишь количественными.
Code-switches of the English Department students combine units of Russian, English, and German. The aim of the paper is to describe longitudinally structural, pragmatic, and semantic characteristics of code-switches in the speech of second-, third-, and fourth-year University students majoring in Linguistics. The data include 201 bilingual and trilingual utterances observed and recorded in a written form while the students interacted orally in-between their classes in the University building. The authors use a mixed-method approach to analyze the multilingual data. The originality of the work lies in the longitudinal approach (three years long) employed to provide a multifaceted analysis (in three aspects) of the multilingual students’ speech in the similar communicative situations. The analysis demonstrated the following results: 1) the most frequent are island switches and insertions proper, 2) the students used code-switches mainly to denote objects of their classroom and every-day life, 3) the pragmatics of code-switches reflects the students’ desire to have fun while speaking about important things. The longitudinal analysis revealed mostly quantitative differences in all three aspects.
Museum Pusaka Keraton Kesepuhan Cirebon, Jawa Barat (Kajian Tentang Sejarah Koleksi Dan Potensinya Sebagai Sumber Belajar Sejarah Di SMA)
Authors: Nova Dena Putri Irawan  , I Wayan Putra Yasa  , I Wayan Pardi  
Published: April 2024

Keraton Kesepuhan Cirebon merupakan salah satu kerajaan Islam yang berada di Indonesia berdiri dari abad ke-14 hingga kemerdekaan Indonesia. Keraton Kesepuhan Cirebon ini juga ikut berperan aktif dalam penyebaran agama Islam di Pulau Jawa khusus nya di daerah barat. Perkembangan kerajaan yang semakin besar hingga bisa mendapatkan teman untuk berpolitik dari berbagai daerah yang ada di Indonesia hingga kerajaan-kerajaan di luar Indonesia. Kerjasama dengan kerajaan-kerajaan yang berada di luar Indonesia membuat Keraton Kesepuhan Cirebon sering kali mendapatkan barang-barang hadiah dari kerajaan sekutu. Barang-barang yang memiliki manfaat tinggi bagi Keraton Kesepuhan Cirebon serta memiliki nilai yang indah untuk dilihat oleh banyak orang. Barang-barang tersebut masih ada hingga sekarang, untuk menjaga peninggalan-peninggalan dari Keraton Kesepuhan Cirebon pihak pemerintah daerah mengusulkan pembuatan Museum. Hingga pada tahun 2015 Museum disahkan untuk menjadi tempat benda-benda bersejarah. Museum tersebut bernama Museum Pusaka Keraton Kesepuhan Cirebon, walaupun nama nya museum pusaka isi dari museum tersebut bukan hanya pusaka saja melainkan ada benda-benda budaya yang memiliki nilai seni yang tinggi. Benda-benda peninggalan nya memang kebanyakan tentang pusaka dan senjata peninggalan yang masih bisa dipamerkan dimuseum. Benda-benda koleksi museum yang tentang budaya salah satunya gamelan benda peninggalan yang sampe sekarang memiliki nilai kebudayaan tinggi di pikiran masyarakat. Koleksi-koleksi dari Museum Pusaka Keraton Kesepuhan Cirebon ini akan membuat kita merasakan nuansa jaman kerajaan dulu. Setiap koleksi yang dipamerkan memiliki cerita nya sendiri sehingga membuat pengunjung merasa keunikan museum tersebut.
Kata kunci: Keraton Kesepuhan, Museum, Koleksi
Cristina Fernández de Kirchner y la “década ganada”. Discurso presidencial y hegemonía: líder, pueblo y proyecto
Authors: Varesi Gastón Ángel 
Published: April 2024

El artículo se propone analizar los discursos de Cristina Fernández de Kirchner sobre la “década ganada” como parte del proceso de construcción de hegemonía. Para ello, seleccionamos un corpus guiado por criterios temporales, tomando sus intervenciones públicas del año 2013, y también temático, focalizándonos en aquellos discursos donde hace un uso explícito de esta noción. Desde una mirada sociológica, sintetizamos diversos aspectos de la teoría gramsciana de la hegemonía, indagando acerca del proceso de dirección política, ideológica y cultural, observando el rol del líder, del proyecto y de la voluntad colectiva. Asimismo, recuperamos diversos aportes de Charaudeau sobre el discurso político, examinando la lógica simbólica y pragmática que adquiere, sus condiciones de veracidad y la imagen que el orador proyecta de sí mismo, al tiempo que vamos introduciendo distintas definiciones complementarias del concepto de populismo al análisis. Nos preguntamos: ¿cómo se construye la relación líder/pueblo en el discurso presidencial? ¿qué lectura plantea sobre el proyecto y su gobierno, y cómo se los inscribe en la historia nacional? ¿cuál es el balance de la década realizado? ¿cuáles son las dimensiones y escalas involucradas en el discurso de la “década ganada”? ¿qué continuidades y variaciones expresa dicho discurso en relación a la construcción originaria de la hegemonía kirchnerista?
Tendências temáticas na produção científica brasileira
Authors: Souza Kellcia Rezende , Scaff Elisangela Alves da Silva 
Published: April 2024

A Lei Federal n. 11.274/2006 amplia para nove anos o Ensino Fundamental, com a matrícula de crianças aos seis anos de idade. Tal política da ampliação tem gerado discussões no que se refere a sua implantação e às questões decorrentes deste processo. Sendo assim, o objetivo deste trabalho consiste em analisar as tendências temáticas acerca das pesquisas científicas produzidas sobre o Ensino Fundamental de nove anos. Trata-se do estado da arte acerca da temática, o qual foi realizado mediante revisão da literatura de cunho qualitativo, sendo analisados teses, dissertações, periódicos e artigos publicados em eventos entre os anos de 2005-2011. As produções sinalizam para a pluralidade de temáticas que perpassam pelas produções sobre o Ensino Fundamental de nove anos, o qual propicia destacar a importância de discussões nos municípios e nos estados e a importância da preocupação com as diversas formas de interpretação e sentidos que uma lei e suas orientações podem promover no interior da escola.
Universidade e pesquisa
Authors: Rodrigo Lidia Maria 
Published: April 2024

Entre as múltiplas funções educativas da universidade, ensino e pesquisa costumam merecer especial destaque. O ensino refere-se à disseminação dos produtos do conhecimento consolidado; a pesquisa consiste, em termos gerais, na busca e produção de novos conhecimentos. Esta última, em lugar de enfatizar o produto do conhecimento, como faz o ensino, enfatiza, sobretudo, os processos de sua produção. Compete à universidade propiciar ao estudante o acesso a essas duas formas de relação com o saber.
Incidental and anticipated arrhythmic diagnoses in patients with an implantable cardiac monitor
Authors: Maines Massimiliano , Rotondi Francesco , Guarracini Fabrizio , Esposito Cristina , Peruzza Francesco , Vitillo Paolo , Kola Nertil , Quintarelli Silvia , Franculli Fabio , Napoli Paola , Giacopelli Daniele , Del Greco Maurizio , Di Lorenzo Emilio , Marini Massimiliano 
Published: April 2024

Aims
In this study, we investigated a cohort of unselected patients with various indications for an implantable cardiac monitor (ICM). Our main objectives were to determine the incidence of arrhythmic diagnoses, both anticipated and incidental in relation to the ICM indication, and to assess their clinical relevance.

Methods
We examined remote monitoring transmissions from patients with an ICM at four Italian sites to identify occurrences of cardiac arrhythmias. Concurrently, we collected data on medical actions taken in response to arrhythmic findings.

Results
The study included 119 patients, with a median follow-up period of 371 days. ICM indications were syncope/presyncope (46.2%), atrial fibrillation management (31.1%), and cryptogenic stroke (22.7%). In the atrial fibrillation management group, atrial fibrillation was the most common finding, with an incidence of 36% [95% confidence interval (CI) 22–55%] at 18 months. Rates of atrial fibrillation were not significantly different between patients with cryptogenic stroke and syncope/presyncope [17% (95% CI 7–40%) vs. 8% (95% CI 3–19%), P = 0.229].
For patients with cryptogenic stroke, the incidence of asystole and bradyarrhythmias at 18 months was 23% (95% CI 11–45%) and 42% (95% CI 24–65%), respectively, similar to estimates obtained for patients implanted for syncope/presyncope (P = 0.277 vs. P = 0.836).
Overall, 30 patients (25.2%) required medical intervention following ICM-detected arrhythmias, predominantly involving atrial fibrillation ablation (10.9%) and medication therapy changes (10.1%).

Conclusion
In a real-life population with heterogeneous insertion indications, approximately 25% of patients received ICM-guided medical interventions within a short timeframe, including treatments for incidental findings. Common incidental arrhythmic diagnoses were bradyarrhythmias in patients with cryptogenic stroke and atrial fibrillation in patients with unexplained syncope.
Frases utilizadas en la comunicación médica, su tiempo y frecuencia
Authors: Placencia-Ibadango Martha Verónica , Vargas-Vera Ramón Miguel , Pinillo María Fernanda Yagual , Placencia-Ibadango Silvia Maribel , Alencastro Placencia Saul Alexander , Vargas-Silva Kathiuska Steffany , Vargas-Silva Kalid Stefano , Zambrano-Burbano Moisés Steven 
Published: April 2024

Introducción. – El tiempo de la consulta médica ha sido un tema de preocupación, así como la comunicación, lo que parece ser un indicador en casi todas las acciones de la entrevista médico-paciente. Objetivo. - Interpretar los términos y frases en la consulta médica en un hospital de la ciudad y evaluar el tiempo en la comunicación que existe entre el médico y paciente. Método. – Estudio observacional, descriptivo, prospectivo de corte transversal realizado en 3 fases: Fase 1 observación y selección de los términos obtenidos en la consulta médico-paciente; fase 2 registro de los términos por frecuencia, su utilización y el tiempo empleado en la consulta médica; fase 3 selección de equivalencia en ingles utilizando traductores bibliográficos. Resultados. – Se identificaron 78 términos o frases en la consulta médica; 59 provenían de los pacientes y 19 de los médicos, usados frecuentemente en la consulta médica de ginecología y medicina interna. El tiempo promedio en cada consulta fue de 20 minutos. Conclusiones. - Los médicos como los pacientes tienen derechos y obligaciones a respetarse basado de una vertiente sociológica y ética, por lo tanto, la consulta del ejercicio profesional en la salud, deben considerar el tiempo y opiniones de los pacientes, así como del médico para contemplar la dignidad de la atención del profesional.