bluuebunny/crossref_metadata_2025_split huggingface dataset:
Primary (AL) Amyloidosis in Plasma Cell Disorders
Authors: Müller Antonia M. S. , Geibel Annette , Neumann Hartmut P. H. , Kühnemund Alexander , Schmitt-Gräff Annette , Böhm Joachim , Engelhardt Monika 
Published: August 2006

Abstract

Learning Objectives
After completing this course, the reader will be able to: Describe the pathogenesis of AL amyloidosis.Identify other disorders often associated with AL amyloidosis.Discuss the importance of the prompt diagnosis and treatment of AL amyloidosis and any underlying plasma cell disorder.Identify presenting signs and symptoms that should lead to the suspicion of AL amyloidosis.
Access and take the CME test online and receive 1 AMA PRA Category 1 Credit™ at CME.TheOncologist.com
Primary (AL) amyloidosis is the most common form of systemic amyloidosis. The morbidity arises from extracellular deposition of immunoglobulin light chain (LC) fibrils in major organs, such as the kidneys, heart, and bowel. Organ dysfunction contributes to a high mortality and poor prognosis, with a median survival time of 1–2 years from diagnosis. Here, we present a 46-year-old man with an exceptional clinical course of an LC multiple myeloma with generalized amyloidosis, causing renal insufficiency, congestive heart failure, and complete intestinal necrosis. We have summarized recent knowledge on AL amyloidosis, its association with monoclonal gammopathies, clinical presentations, diagnostic tools, and treatment strategies. Our comprehensive overview of this rare and often fatal disease aims to increase the awareness of AL amyloidosis. This may facilitate earlier diagnosis, and thus allow initiation of prompt and specific therapies, which are indispensable in order to improve disease prognosis.
Anaplastic Large-Cell Lymphoma, T-/Null-Cell Type
Authors: Jacobsen Eric 
Published: August 2006

Abstract

Learning Objectives
After completing this course, the reader will be able to: Identify areas of diagnostic confusion in anaplastic large-cell lymphoma (ALCL).Describe risk stratification in ALCL.Discuss therapeutic options in ALCL.
Access and take the CME test online and receive 1 AMA PRA Category 1 Credit™ at CME.TheOncologist.com
Anaplastic large-cell lymphoma, T-/null-cell type (ALCL), is a rare disease that has only been well characterized for two decades. Despite this, the biology of ALCL is better understood than that of many other more common variants of lymphoma. This review focuses on the pathophysiology, clinical presentation, and therapy of ALCL, including stem cell transplantation. In particular, the text emphasizes how novel prognostic features and the evolving understanding of the biology of this disease will influence treatment selection and drug development.
Antibacterial Natural Products in Medicinal Chemistry—Exodus or Revival?
Authors: von Nussbaum Franz , Brands Michael , Hinzen Berthold , Weigand Stefan , Häbich Dieter 
Published: August 2006

AbstractTo create a drug, nature's blueprints often have to be improved through semisynthesis or total synthesis (chemical postevolution). Selected contributions from industrial and academic groups highlight the arduous but rewarding path from natural products to drugs. Principle modification types for natural products are discussed herein, such as decoration, substitution, and degradation. The biological, chemical, and socioeconomic environments of antibacterial research are dealt with in context. Natural products, many from soil organisms, have provided the majority of lead structures for marketed anti‐infectives. Surprisingly, numerous “old” classes of antibacterial natural products have never been intensively explored by medicinal chemists. Nevertheless, research on antibacterial natural products is flagging. Apparently, the “old fashioned” natural products no longer fit into modern drug discovery. The handling of natural products is cumbersome, requiring nonstandardized workflows and extended timelines. Revisiting natural products with modern chemistry and target‐finding tools from biology (reversed genomics) is one option for their revival.
Solid‐Phase Synthesis of Tetrahydro‐β‐carbolines and Tetrahydroisoquinolines by Stereoselective Intramolecular N‐Carbamyliminium Pictet–Spengler Reactions
Authors: Diness Frederik , Beyer Jürgen , Meldal Morten 
Published: August 2006

AbstractA solid‐phase method for the synthesis of tri‐, tetra‐, and pentacyclic compounds containing tetrahydro‐β‐carboline, tetrahydroisoquinoline or analogous scaffolds is presented. The reaction proceeds with high stereoselectivity through an intermediate N‐carbamyliminium ion that exclusively converts into Pictet–Spengler‐type products with a variety of C‐nucleophiles. Amino aldehydes masked with 3‐Boc‐(1,3)‐oxazinane (Box) have been synthesized from amino acids, amino alcohols, or 2‐nitro benzaldehydes. The amino moiety of these masked aldehydes has been converted into pentafluorophenyl carbamate to serve as a urea precursor. The building blocks were incorporated at the N‐terminal of a resin‐supported dipeptide through urea formation. Subsequent treatment with acid liberated the aldehyde quantitatively. A penultimate tryptophan residue gave rise, under the acetic conditions, to a spontaneous intramolecular Pictet–Spengler reaction with the liberated aldehyde. The reaction proceeded with a high degree of stereoselectivity affording tetrahydro‐β‐carbolines with a de (de=diastereomeric excess) above 95 % and purity in the range of 90–99 %. This reaction has been extended to a range of other aromatic C‐nucleophiles, including substituted indoles, benzenes, pyrene, furan, thiophenes, and benzothiophene with comparable stereoselectivity and purity. Prolonged exposure of the benzaldehyde‐derived Pictet–Spengler products to strong acid and air lead to quantitative auto‐oxidation which yielded compounds with a 3,4‐dihydro‐β‐carboline, a 3,4‐dihydroisoquinoline, or a similar core structure.
The Room‐Temperature Superstructure of ZrP2O7 Is Orthorhombic: There Are no Unusual 180° P—O—P Bond Angles.
Authors: Birkedal Henrik , Krogh Andersen Anne Marie , Arakcheeva Alla , Chapuis Gervais , Norby Poul , Pattison Philip 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Syntheses, Properties and Cyrstal Structures of the Cluster Salts Bi6[PtBi6Cl12] and Bi2/3[PtBi6Cl12].
Authors: Hampel Silke , Ruck Michael 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Luminescent Properties of Eu‐Doped Germanate Apatite Sr2La8(GeO4)O2.
Authors: Li Yu‐Chun , Chang Yen‐Hwei , Tsai Bin‐Siang , Chen Yu‐Chung , Lin Yu‐Feng 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis and Photoluminescence of Ce3+‐Doped Barium Haloapatites Nanocrystals.
Authors: Xiu Zhiliang , Lue Mengkai , Liu Suwen , Zhou Guangjun , Zhang Haiping 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Formation Enthalpies of Fe—Al—RE Ternary Alloys Calculated with a Geometric Model and Miedema′s Theory.
Authors: Ouyang Yifang , Zhong Xiaping , Du Yong , Jin Zhanpeng , He Yuehui , Yuan Zhaohui 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Facilitated Hydrogen Storage in NaAlH4 Supported on Carbon Nanofibers.
Authors: Balde Cornelis P. , Hereijgers Bart P. C. , Bitter Johannes H. , de Jong Krijn P. 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Catalysis in Capillaries by Pd Thin Films Using Microwave‐Assisted Continuous‐Flow Organic Synthesis (MACOS).
Authors: Shore Gjergji , Morin Sylvie , Organ Michael G. 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Catalytic Asymmetric Addition of Dimethylzinc to α‐Ketoesters, Using Mandelamides as Ligands.
Authors: Blay Gonzalo , Fernandez Isabel , Marco‐Aleixandre Alicia , Pedro Jose R. 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Practical Chiral Bicyclic Thioglycolate Lactam Auxiliary for Stereoselective Quaternary Carbon Formation.
Authors: Arpin Azelie , Manthorpe Jeffrey M. , Gleason James L. 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Preparation of Pyrrolidine‐Based PDE4 Inhibitors via Enantioselective Conjugate Addition of α‐Substituted Malonates to Aromatic Nitroalkenes.
Authors: Nichols Paul J. , DeMattei John A. , Barnett Bradley R. , LeFur Nicole A. , Chuang Tsung‐Hsun , Piscopio Anthony D. , Koch Kevin 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Catalytic Asymmetric Cyano‐Phosphorylation of Aldehydes Using a YLi3tris(binaphthoxide) Complex (YLB).
Authors: Yamagiwa Noriyuki , Abiko Yumi , Sugita Mari , Tian Jun , Matsunaga Shigeki , Shibasaki Masakatsu 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Enantioselective Intramolecular [2 + 2 + 2] Cycloaddition of Triynes for the Synthesis of Atropisomeric Chiral ortho‐Diarylbenzene Derivatives.
Authors: Shibata Takanori , Tsuchikama Kyoji , Otsuka Maiko 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Use of Bis(benzimidazolium) — Palladium System as a Convenient Catalyst for Heck and Suzuki Coupling Reactions of Aryl Bromides and Chlorides.
Authors: Demir Serpil , Oezdemir Ismail , Cetinkaya Bekir 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Convenient Removal of N‐tert‐Butyl from Amides with Scandium Triflate.
Authors: Mahalingam A. K. , Wu Xiongyu , Alterman Mathias 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
High Stereocontrol in the Allylation of Chiral Non‐Racemic α‐Alkoxy and α‐Amino Nitrones.
Authors: Merino Pedro , Delso Ignacio , Mannucci Vanni , Tejero Tomas 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Lewis Acid Catalyzed Conjugate Addition and the Formation of Heterocycles Using Michael Acceptors under Solvent‐Free Conditions.
Authors: Mekonnen Alemayehu , Carlson Rolf 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Direct Palladium/Carboxylic Acid‐Catalyzed Allylation of Anilines with Allylic Alcohols in Water.
Authors: Yang Shyh‐Chyun , Hsu Yi‐Chun , Gan Kim‐Hong 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Highly Enantioselective Broensted Acid Catalyst for the Strecker Reaction.
Authors: Rueping Magnus , Sugiono Erli , Azap Cengiz 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Arylanthranilodinitriles: A New Biaryl Class of Antileishmanial Agents.
Authors: Singh Fateh V. , Vatsyayan Rit , Roy Uma , Goel Atul 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Highly Enantioselective Organocatalyst for the Michael Addition of Cyclic Ketones to Nitroolefins.
Authors: Zhu Ming‐Kui , Cun Lin‐Feng , Mi Ai‐Qiao , Jiang Yao‐Zhong , Gong Liu‐Zhu 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Highly Enantioselective 1,4‐Addition of Arylzinc Reagents to 3‐Arylpropenals Catalyzed by a Rhodium—Binap Complex in the Presence of Chlorotrimethylsilane.
Authors: Tokunaga Norihito , Hayashi Tamio 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Reactions of Acceptor Thiophene 1,1‐Dioxides with Dienes. Synthesis of Bisadducts.
Authors: Nenajdenko V. G. , Moiseev A. M. , Balenkova E. S. 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Molybdenum‐Catalyzed Asymmetric Allylation of 3‐Alkyloxindoles: Application to the Formal Total Synthesis of (‐)‐Physostigmine.
Authors: Trost Barry M. , Zhang Yong 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
β‐Tosylethylazide: A Useful Synthon for Preparation of N‐Protected 1,2,3‐Triazoles via Click Chemsitry.
Authors: Yap Amy H. , Weinreb Steven M. 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis and Structure—Activity Relationship of a Novel, Achiral Series of TNF‐α Converting Enzyme Inhibitors.
Authors: Gilmore John L. , et al. et al. 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis and Crystal Structure of 3‐Ethoxycarbonyl‐4,6‐diphenyl‐3,4‐dihydropyridine‐2(1H)‐thione.
Authors: Dyachenko V. D. 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis and SAR of 1,9‐Dihydro‐9‐hydroxypyrazolo[3,4‐b]quinolin‐4‐ones as Novel, Selective c‐Jun N‐Terminal Kinase Inhibitors.
Authors: Liu Mei , et al. et al. 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Vasorelaxant Activity of Phthalazinones and Related Compounds.
Authors: del Olmo Esther , Barboza Bianca , Ybarra M. Ines , Lopez‐Perez Jose Luis , Carron Rosalia , Sevilla M. Angeles , Boselli Cinthia , San Feliciano Arturo 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Studies in Quinazoline Chemistry. Part 3. Synthesis of 2‐(2‐Pyridon‐3‐yl)‐ and 2‐[Thieno[2,3‐b]pyridin‐2(3)‐yl]‐3,4‐dihydroquinazolines.
Authors: Gromachevskaya E. V. , Kaigorodova E. A. , Firgang S. I. , Krapivin G. D. 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis and Biological Evaluation of a Novel Structural Type of Serotonin 5‐HT3 Receptor Antagonists.
Authors: Perumal Ramachandran Venkatesha , Mahesh Radhakrishnan 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Acylation of Dibenzo‐18‐crown‐6 with Alkali‐Metal Acetates in Polyphosphoric Acid.
Authors: Saifullina N. Zh. , Tashmukhamedova A. K. 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of Some New Fused and Polyfused [1,2,4]Triazolo[3,4‐b][1,3,4]thiadiazepines.
Authors: Allah O. A. Abd 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of Substituted 2‐Cyanoarylboronic Esters.
Authors: Lysen Morten , Hansen Henriette M. , Begtrup Mikael , Kristensen Jesper L. 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
One‐Pot Borylation/Amination Reactions: Syntheses of Arylamine Boronate Esters from Halogenated Arenes.
Authors: Holmes Daniel , Chotana Ghayoor A. , Maleczka Robert E. Jr. , Smith Milton R. III 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Facile Synthesis of Steroidal Pyrazoles, Isoxazoles and Pyrimidines from Testosterone.
Authors: Singh Ch. Brajakishor , Singh L. Warjeet 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Novel 1‐tert‐Butoxy‐2‐tert‐butoxycarbonyl‐1,2‐dihydroisoquinoline (BBDI)‐Catalyzed Esterification of N‐Protected Amino Acids with Nearly Equimolar Amounts of Alcohols in the Presence of Boc2O.
Authors: Saito Yukako , Watanabe Tomokazu , Takahata Hiroki 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Design, Synthesis, and Biological Activities of Madindoline Analogues.
Authors: Yamamoto Daisuke , Sunazuka Toshiaki , Hirose Tomoyasu , Kojima Naoto , Kaji Eisuke , Omura Satohsi 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of [125I]‐, [2H]‐, and [3H]‐Labeled 3‐Iodothyronamine (T1AM).
Authors: Miyakawa Motonori , Scanlan Thomas S. 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Marine Bacteria. Part 33. Prefluostatin and New Urauchimycin Derivatives Produced by Streptomycete Isolates.
Authors: Yao C. B. Fondja , Schiebel M. , Helmke E. , Anke H. , Laatsch H. 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Efficient Formal Synthesis of (.+‐.)‐Hyphodermin B (I).
Authors: Henderson Luke C. , Loughlin Wendy A. , Jenkins Ian D. , Healy Peter C. , Campitelli Marc R. 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of Cicerfuran (Ia), an Antifungal Benzofuran, and Some Related Analogues.
Authors: Aslam Shazia N. , Stevenson Philip C. , Phythian Sara J. , Veitch Nigel C. , Hall David R. 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
The Role of Interstitial Mn in GaAs‐Based Dilute Magnetic Semiconductors
Authors: Kacman Perla , Kuryliszyn‐Kudelska Izabela 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of Organochalcogen Compounds in Basic Reducing Systems
Authors: Deryagina E. N. , Russavskaya N. V. , Papernaya L. K. , Levanova E. P. , Sukhomazova E. N. , Korchevin N. A. 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Peptide Nucleic Acid Conjugates: Synthesis, Properties and Applications
Authors: Zhilina Zhanna V. , Ziemba Amy J. , Ebbinghaus Scot W. 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Novel Routes to Pyrroles, Indoles and Carbazoles: Applications in Natural Product Synthesis
Authors: Agarwal Sameer , Caemmerer Simon , Filali Salima , Froehner Wolfgang , Knoell Jan , Krahl Micha P. , Reddy Kethiri R. , Knoelker Hans‐Joachim 
Published: August 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.