bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel prognostic scoring system combining the revised Tokuhashi score and the New England spinal metastasis score for preoperative evaluation of spinal metastases
Authors: Mavritsakis Dionisia , Amiot Louis-Philippe 
Published: March 2024

PurposeNumerous scoring systems have been developed in order to determine the prognosis of spinal metastases. Predicting as accurately as possible the life expectancy of patients with spinal metastatic disease is very important, as it's the decisive factor in selecting the optimal treatment for the patient. The Revised Tokuhashi score (RTS) and the New England Spinal Metastasis score (NESMS) are popular scoring systems used to determine the optimal treatment modality. However, they sometimes provide conflicting results. We propose a novel prognostic scoring system, which combines the RTS and NESMS scores in order to predict with greater accuracy the prognosis.MethodsWe retrospectively reviewed the data of 64 patients with spinal metastasis enrolled between 2012 and 2021 in the Department of Orthopedic Surgery-Spine, Hôpital Maisonneuve-Rosemont, Montréal, Que. The new score per patient was calculated as a combination of the RTS of each patient and the patient's corresponding NESMS. The new score was then compared to the actual patient survival period and divided into 3 categories: Low, Moderate and Good prognosis. We then compared the accuracy of our new score to RTS.ResultsIn the Low Prognosis group, the reliability of predicting the prognosis was 51.9% in 27 patients. In the Moderate Prognosis group, the reliability of predicting the prognosis was 95.8% in 24 patients. In the Good Prognosis group, the reliability of predicting the prognosis was 100% in 13 patients. Our new score was found more accurate than RTS as the R2 parameter corresponding to the new score was significantly increased compared to the same parameter corresponding to the RTS score indicating a higher percentage of survival predictability for the new score as compared to the RTS score.ConclusionThis study demonstrates that a new prognostic scoring system, which would combine the RTS and the NESMS, is promising in providing an improved accuracy for predicting the actual patient survival, especially for the moderate and good prognosis patients. An appropriate prospective investigation with a larger sample size should be conducted in order to further investigate the validity of this novel scoring system and its overall predictive value.
Evaluation of anti-Fel d 1 IgY ingredient for pet food on growth performance in kittens
Authors: Hedrick Erik D. , Matulka Ray A. , Conboy-Schmidt Lisa , May Kimberly A. 
Published: March 2024

IntroductionThe domestic cat (Felis catus) is one of the most common pets. Worldwide, approximately one in five adults are sensitive to cat allergens. The major cat allergen is the secretoglobulin Fel d 1, which is primarily produced in the salivary and sebaceous glands. Chickens produce IgY antibodies, which are similar in structure to mammalian IgG. When chickens are exposed to Fel d 1, anti-Fel d 1-specific IgY (AFD1) is produced and is naturally concentrated in egg yolk. The aim of this study was to evaluate the tolerability, effects on growth and food consumption, and potential adverse effects of a chicken egg product ingredient containing AFD1 in kittens.MethodsThis was a blinded, controlled study. Twenty-seven (27) eight-week old kittens were randomly assigned to three feeding groups containing 0 ppm AFD1 (Group 0), 8 ppm AFD1 (Group 1), and 16 ppm AFD1 (Group 2) for 84 days. Veterinary exams and bloodwork were performed on Day 42 and Day 84, and body weight and body condition score (BCS) were monitored weekly.ResultsThroughout the study, there were no signs of nutritional deficiency or adverse clinical events in any of the subjects. Administration of a chicken egg product ingredient containing AFD1 in the diet (whether in coating or combination of coating and top dress) had no significant effect on body weight nor food consumption, and all subjects maintained a healthy Body Condition Score (BCS) throughout the study. Moreover, there were no biologically significant differences in the mean clinical chemistry and hematology parameters.DiscussionThis study demonstrated that a diet formulated to contain up to 16  ppm AFD1, included in the coating and the top-dress of dry kitten food, was well tolerated, promoted adequate growth, and exhibited no adverse effects.
Physico-Mechanical and Energy Properties of Pine (Pinus sylvestris) and Beech (Fagus sylvatica) Wood from Railroad Ties
Authors: Aniszewska Monika , Gendek Arkadiusz , Tamelová Barbora , Malaťák Jan , Velebil Jan , Krilek Jozef , Čabalová Iveta , Mikłaszewicz Ireneusz , Zychowicz Witold , Drożdżek Michał , Mazurek Andrzej 
Published: March 2024

The objective of the present work was to determine the physico-mechanical and energy properties of pine (Pinus sylvestris) and beech (Fagus sylvatica) wood from railroad ties. The ties were divided into internal and external parts as well as into parts impregnated and unimpregnated with creosote oil. The effects of creosote impregnation on wood hardness, compressive strength parallel to the grain, static bending strength, and calorific value were studied. The obtained results show that the parameters of the analyzed samples meet the standard requirements (EN 338) for construction wood (compressive and bending strength class: C50—pine; D70—beech). Depending on the particular property being studied, both pine and beech samples belong to the highest or one of the highest wood quality classes. Creosote oil considerably increased wood density (by 9% for beech and 19% for pine) but did not affect its hardness. Creosote impregnation significantly improved the compressive strength parallel to the grain of both wood species (beech: σc=51.99 MPa (IN); σc=57.78 MPa (OUT); pine: σc=36.56 MPa (IN); σc=42.45 MPa (OUT)); in the case of static bending strength, its value was increased for beech wood (σg=106.13 MPa (IN); σg=113.18 MPa (OUT)) and reduced for pine wood (σg=66.34 MPa (IN); σg=82.62 MPa (OUT)). The oil contained in wood from ties significantly elevated its calorific value (by 25% for beech and 10% for pine). Unfortunately, the presence of creosote oil currently prevents wood from railroad ties from being reused as the oil is deemed hazardous and carcinogenic. However, if it were possible to isolate the unimpregnated parts of railroad ties, they could be reapplied for construction or other uses.
CURRENT PROBLEMS OF POLYPHARMACY IN GERIATRIC PATIENTS WHEN TAKING DRUGS WITH A RISK OF PHOTOSENSITIVITY
Authors: Башкирёва А.С. , Колосова Г.В. , Баранова Н.П. , Богданова Д.Ю. , Бондаренко Т.В. , Шишко А.В. , Асатрян А.Г. , Аникеев П.П. 
Published: March 2024

В статье представлен обзор актуальных проблем полипрагмазии у гериатрических пациентов при приеме лекарственных средств с риском фотосенсибилизации. Статья содержит сведения о возникающих нежелательных лекарственных реакциях, а также методах диагностики, коррекции и профилактики фототоксических и фотоаллергических реакций у пациентов старших возрастных групп. Изложены основные аспекты дерматологического сопровождения в системе долговременного ухода за гериатрическими пациентами при приеме данных лекарственных средств. Изучены клинические признаки старческого ксероза и нежелательных лекарственных реакций кожи при приёме лекарственных средств с риском фотосенсибилизации до и после применения фотопротектора у пациентов пожилого возраста.
The article presents an overview of the current problems of polypharmacy in geriatric patients when taking drugs with a risk of photosensitivity. The article contains information about emerging adverse drug reactions, as well as methods for diagnosing, correcting and preventing phototoxic and photoallergic reactions in patients of older age groups. The main aspects of dermatological support in the system of long-term care for geriatric patients when taking drugs with a risk of photosensitivity are outlined. Clinical signs of senile xerosis and skin manifestations of adverse drug reactions were studied when taking drugs with the risk of photosensitization before and after the use of a photoprotector in elderly patients.
MODERN DETERMINANTS OF INTERGENERATIONAL RELATIONSHIPS
Authors: Первова И.Л. , Келасьев В.Н. , Михайлова О.Н. 
Published: March 2024

В статье рассмотрены межпоколенные взаимоотношения и взаимооценки, дается представление о ценностях молодежи и пожилых, полученных на основе интервьюирования. Авторы приходят к выводу о естественности изменчивости межпоколенных взаимоотношений, которые ввиду адаптивных возможностей не приводят к реальному конфликту между рассматриваемыми возрастными группами.
The article deals with intergenerational relationships and mutual assessments, gives an idea of the values of young people and the elderly, obtained on the basis of interviews. The authors come to the conclusion about the natural variability of intergenerational relationships, which due to adaptive capabilities, do not lead to real conflict between the studied age groups.
CHANGES IN TELOMERE LENGTH IN LEUKOCYTES OF MALE RHESUS MACAQUES OF DIFFERENT AGES
Authors: Тимина М.Ф. , Павлова Л.Е. , Киргинцев Р.М. , Агумава А.А. 
Published: March 2024

Теломеры представляют собой специализированные концевые участки хромосом, обеспечивающие стабильность последних. Удвоение ДНК при делении клетки связано с укорочением теломер вследствие феномена концевой недорепликации. По мере деления клеток укорочение длины теломер считается одной из важнейших причин старения клетки. Оценка длины теломер до настоящего времени остается предметом научных исследований в области геронтологии и не применяется в клинической практике. Чаще всего в качестве модельного объекта изучения процессов старения используют грызунов, однако нейроэндокринные механизмы, влияющие в том числе на регуляцию процесса старения, отличаются у грызунов и человека. Наиболее близким в филогенетическом отношении к человеку модельным объектом являются обезьяны, в частности макаки резусы — один из чаще всего используемых в биомедицинских исследованиях представителей Старого Света. Однако данные об изменении длины теломер у низших обезьян с возрастом крайне немногочисленны. Мы изучили абсолютную среднюю длину теломер ДНК лейкоцитов крови у 29 клинически здоровых самцов макак резусов 4–24 лет методом количественной ПЦР. Полученные данные не соответствовали нормальному характеру распределения, а корреляционный анализ показал отсутствие значимой зависимости длины теломер от возраста животных (rs=0,27, p>0,05). Таким образом, наше исследование не подтверждает зависимость изменения средней длины теломер лейкоцитов крови с возрастом.
Telomeres are specialized terminal sections of chromosomes that ensure the stability of the latter. DNA duplication during cell division is associated with telomere shortening due to the phenomenon of terminal underreplication. As cells divide, shortening of telomere length is considered to be one of the most important causes of cell aging. Estimation of telomere length still remains the subject of scientific research in gerontology and it is not used in clinical practice. Most often, rodents are used as a model object for studying the aging process, but the neuroendocrine mechanisms that influence, among other things, the regulation of the aging process differ in rodents and humans. The model objects closest in phylogenetic relation to humans are monkeys. In particular, Rhesus macaques is one of the representatives of the Old World most often used in biomedical research. However, data on age-related changes in telomere length in monkeys are extremely scarce. We studied the absolute average length of telomeres in DNA from blood leukocytes of 29 clinically healthy male rhesus monkeys aged from 4 to 24 years using quantitative PCR-method. The data obtained did not correspond to the normal distribution and the correlation analysis showed the absence of a significant dependence of telomere length on the age of the animals (rs=0,27; p>0,05). Thus, our study does not confirm the dependence of changes in the average length of telomeres of blood leukocytes with age.
Chemical And Organoleptic Characteristics Of Snack Bars Based On Yellow Sweet Potato Flour (Ipomoea batatas L) And Mung Bean Flour (Vigna radiata)
Authors: Solin Dwi Putriana , Ludong Maya M. , Lamaega Jolanda Ch. E. 
Published: March 2024

ABSTRACT
The purpose of the study was to analyze the characteristics of chemistry, test the favorability level of panelists, and determine the best treatment of snack bars based on yellow sweet potato flour and green bean flour. Snack bar is a snack in the form of bars made from cereals or beans and snack bars are usually used for breakfast or as snacks. This research method uses the Complete Randomized Design (RAL) research method with 4 treatments of 3 repetitions, namely with treatment A (80% yellow sweet potato flour and 20% mung bean flour), B (70% yellow sweet potato flour and 30% mung bean flour), C (60% yellow sweet potato flour and 40% mung bean flour), D (50% yellow sweet potato flour and 50% mung bean flour). The parameters tested in this study were chemical analysis (water content, protein content, and carbohydrate content) and test the organoleptic (taste, aroma, color, and texture). Based on the panelists' favorability level test for the most preferred snack bar as a whole, it was the mixing of 70% yellow sweet potato flour: 30% mung bean flour, in terms of color 3.52 (likes), aroma 3.72 (likes), taste 3.48 (neutral) and 3.76 textures (likes) with chemical characteristics namely water content 11.96%, protein content 7.58% and carbohydrate content 48.67%.
Keywords: Snack bar, Yellow Sweet Potato Flour, Mung Bean Flour.
ABSTRAK
Tujuan penelitian untuk menganalisis karakteristik kimia dan uji tingkat kesukaan panelis serta menentukan perlakuan terbaik snack bar berbasis tepung ubi jalar kuning dan tepung kacang hijau. Snack bar merupakan makanan ringan yang berbentuk batangan berbahan dasar sereal atau kacang-kacangan dan snack bar biasanya digunakan untuk sarapan atau sebagai makanan ringan. Penelitian ini menggunakan metode penelitian Rancangan Acak Lengkap (RAL) dengan 4 perlakuan 3 kali pengulangan yaitu dengan perlakuan A (80% tepung ubi jalar kuning dan 20% tepung kacang hijau), B (70% tepung ubi jalar kuning dan 30% tepung kacang hijau), C (60% tepung ubi jalar kuning dan 40% tepung kacang hijau), D (50% tepung ubi jalar kuning dan 50% tepung kacang hijau). Parameter yang diuji pada penelitian ini adalah analisis kimia (kadar air, kadar protein, dan kadar karbohidrat) dan uji organoleptik (rasa, aroma, warna, dan tekstur). Berdasarkan uji tingkat kesukaan panelis terhadap snack bar yang paling disukai secara keseluruhan adalah pencampuran 70% tepung ubi jalar kuning: 30% tepung kacang hijau, dari segi warna 3,52 (suka), aroma 3,72 (suka), rasa 3,48 (netral) dan 3,76 tekstur (suka) dengan karekteristik kimia yaitu kadar air 11,96%, kadar protein 7,58% dan kadar karbohidrat 48,67%.
Kata kunci : Snack bar, Tepung Ubi Jalar Kuning, Tepung Kacang Hijau.
Development Of Cookies From Mixed Ingredients Of Sago Flour And Coconut Drugs Flour
Authors: Kesek Praise , Rawung Dekie , Kandou Jenny E. A. 
Published: March 2024

The purpose of this study was to measure the panelists preference for pastries by mixing sogo flour and coconut dregs flour and to find out the water content, protein content, crude fiber content and organoleptic testing of thepanelists preference level. This study used a completely randomized analysis method (CRD). The result showed that the treatment of sogo flour and coconut pulp flour affected the aroma, but did not affect the color, taste and texture of the cake. And based on the response of the panelists to the parameters examined, it showed that the A1 treatment,which was 20g of sogo and 80g of coconut pulp flour, had the highest value compared to other treatments. Namely,with aroma 5.6 (like),color 5.5(slightly like) texture 5.3 (slightly like) taste 5.7 (like)
Keywords: cookies, sogo flour, coconut pulp flour, organoleptic test, water content, protein, crude fiber
Abstrak
Tujuan penelitian ini adalah untuk mengukur tingkat kesukaan panelis terhadap cookies dengan pencampuran tepung sagu dan tepung ampas kelapa dan Mengetahui kandungan kadar air, kadar protein, kadar serat kasar dan pengujian organoleptic tingkat kesukaan dari panelis. Penelitian ini menggunakan metode rancangan acak lengkap (RAL). Hasil penelitian menunjukan bahwa perlakuan tepung sagu dan tepung ampas kelapa berpengaruh terhadap aroma, tetapi tidak berpengaruh terhadap warna, rasa dan tekstur cookies. Dan berdasarkan respon panelis terhadap parameter yang di periksa menunjukan bahwa perlakuan A1 yaitu 20g tepung sagu dan 80g tepung ampas kelapa memiliki nilai tertinggi dibandingkan dengan perlakuan yang lain. Yakni dengan aroma 5,6 (suka) warna 5,5 (agak suka) tekstur 5,3 (agak suka) rasa 5,7 (suka)

Kata kunci: cookies, tepung sagu, tepung ampas kelapa, uji organoleptik, kadar air, protein, serat kasar
Efektifitas Penerapan Sistem Manajemen Terpadu Dalam Peningkatan Kinerja
Authors: Gani Muhammad Jufri , Muhibuddin Andi , Bahri Syamsul 
Published: March 2024

Hasil penelitian menunjukkan bahwa efektifitas penerapan sistem manajemen terpadu (SMT) (ISO series) Dalam Peningkatan Kinerja Pada PT Pelindo Jasa Maritim Makassar. Tahapan-tahapan yang dilaksanakan mulai dengan pelaksanaan Audit Internal, Rapat Tinjauan Manajemen, Audit Eksternal Badan Serftifikasi dan tindaklanjut hasil temuan audit internal/ekternal, sehingga tahapan yang dilaksanakan sesuai dengan kaidah dan klausul yang di persyaratakan oleh sistem manajemen terpadu (ISO Series) dimaksud seperti komitmen, kebijakan, sasaran, pembentukan tim internal, gap analisis, pendidikan dan latihan (diklat) kompetensi Sistim Manajemen Terpadu (ISO series). Adapun faktor pendukung penerapan sistem manajemen terpadu (ISO series) dalam peningkatan kinerja PT. Pelindo Jasa Maritim Makassar, yakni komitmen manajemen, sarana dan prasarana, komunikasi yang efektif dan ketersediaan dana, adapun faktor penghambat yakni budaya kerja, kompetensi dan target waktu.
The result of the research showed that the effectiveness of implementing an Integrated Management System (SMT) (ISO series) in improving performance at PT Pelindo Jasa Maritim Makassar. The stages implemented starting with the implementation of an Internal Audit, Management Review Meeting, External Audit of the Certification Body and follow-up on the result of internal/external audit finding, so that the stages carried out are in accordance with the rules and clauses required by the integrated management system (ISO Series) referred to as commitment, policy, target, internal team formation, gap analysis, education and training (training) Integrated Management System competency (ISO series). The supporting factors for implementing an integrated management system (ISO series) in improving the performance of PT. Pelindo Jasa Maritim Makassar are management commitment, facility and infrastructure, effective communication and availability of funds, while the inhibiting factors are work culture, competence and time target.
PENGARUH KEPEMIMPINAN TRANSFORMASIONAL, KERJASAMA TIM DAN KOMUNIKASI TERHADAP MOTIVASI KERJA KARYAWAN DI PT. AGRICINAL
Authors: Indiani Suci , Onsardi Onsardi 
Published: March 2024

Employee performance is the result of the work or contribution of employees to an organization or company in quality and quantity in accordance with predetermined standards based on the responsibilities given. Employee performance also influences output, timeframe, and attendance at work, as well as cooperative attitudes and professionalism at work. In order for employees to provide good performance for the company, the company needs to pay attention to what factors affect the performance of an employee. This study aims to analyze the effect of transformational leadership, teamwork, and communication on employee performance at PT. North Bengkulu Agriculture This study uses the entire population as respondents, namely as many as 90 people who are registered as employees of PT. Agricinal. Data was collected through observation, interviews, and questionnaires. The results of the data obtained were analyzed using validity and reliability tests. The analysis technique used is the multiple linear regression analysis technique. A transformational leadership style has a positive and significant effect on employee performance. Teamwork has a positive and significant effect on employee performance. Communication has a positive and significant effect on employee performance.
Keywords: Leadership style, Teamwork, Communication, Work motivation,
School Events as a Communication Forum for Dissemination and Internalization of Religious Moderation Values and Student Character Building
Authors: Yohana Corry , Agung Iskandar , Mastiyah Iyoh , Ma'rifataini Lisa'diyah , Ma'rifataini Suprapto , Ma'rifataini Sumarni , Ma'rifataini Herlinawati , Sabon Simon Sili , Sabon Suhanah 
Published: March 2024

Activities at school can be a gateway to programmed and sustainable academic progress. The event in question is a meeting forum at school, outside of learning. The forum is a vehicle for programs to be communicated and seeks to involve related parties. Events at school will have an impact on the internalization of the value of religious moderation and the formation of students' character. This paper aims to examine the factors that influence school events and the impacts they have. These factors are the managerial attitude of the school principal, the role of central and regional government, the potential of the physical environment, and the involvement of the community and parents of students. The research was conducted in 36 elementary schools with 225 teachers. Data collection was carried out by distributing questionnaires, and analysis using SEM techniques. The results of the research found that school activities have not received serious attention as an entry point for school improvement. School events are a forum for program delivery, and can be an entry point for improving education, both student learning outcomes and others. The initiative and creativity of school principals is important for identifying deficiencies in their educational institutions, and becomes the basis for developing improvement programs and involving stakeholder participation to support them.

Received: 24 June 2023 / Accepted: 29 January 2024 / Published: 5 March 2024