bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serum Lipids and the Progression of Nephropathy in Type 1 Diabetes
Authors: Thomas Merlin C. , Rosengård-Bärlund Milla , Mills Vashti , Rönnback Mats , Thomas Stephen , Forsblom Carol , Cooper Mark E. , Taskinen Marja-Riitta , Viberti Giancarlo , Groop Per-Henrik 
Published: May 2006

OBJECTIVE—Dyslipidemia contributes to the progression of microvascular disease in diabetes. However, different lipid variables may be important at different stages of nephropathy. This study examines the pattern of dyslipidemia associated with the progression of nephropathy in patients with type 1 diabetes.
RESEARCH DESIGN AND METHODS—A total of 152 patients with type 1 diabetes were recruited in order to represent various phases of nephropathy. Patients were followed for 8–9 years, during which time they received standard care. Renal progression was defined a priori as a doubling in albumin excretion (in patients with normo- or microalbuminuria) or a decline in creatinine clearance (in those with macroalbuminuria). A panel of lipid variables was determined and correlated with indexes of progression.
RESULTS—In patients with normoalbuminuria (n = 66), progression was associated with male sex (P &lt; 0.05), borderline albuminuria (P = 0.02), and LDL-free cholesterol (P = 0.02). In patients with microalbuminuria (n = 51), progression was independently associated with triglyceride content of VLDL and intermediate-density lipoprotein (both P &lt; 0.05). In patients with macroalbuminuria (n = 36), a significant decline in the renal function (&gt;3 ml · min−1 · year−1) was independently associated with poor glycemic control, hypertension, and LDL size (P &lt; 0.05). When all patients with progressive nephropathy were analyzed together, only LDL cholesterol was predictive on multivariate analysis (P &lt; 0.05), which masked the importance of triglyceride enrichment in microalbuminuria.
CONCLUSIONS—Lipid variables are associated with progression of diabetic kidney disease, but the relationship is not the same at all stages. This finding has implications for the design of renoprotective strategies and the interpretation of clinical trials in type 1 diabetes.
Multicentric, Randomized, Controlled Trial to Evaluate Blood Glucose Control by the Model Predictive Control Algorithm Versus Routine Glucose Management Protocols in Intensive Care Unit Patients
Authors: Plank Johannes , Blaha Jan , Cordingley Jeremy , Wilinska Malgorzata E. , Chassin Ludovic J. , Morgan Cliff , Squire Stephen , Haluzik Martin , Kremen Jaromir , Svacina Stepan , Toller Wolfgang , Plasnik Andreas , Ellmerer Martin , Hovorka Roman , Pieber Thomas R. 
Published: May 2006

OBJECTIVE—To evaluate a fully automated algorithm for the establishment of tight glycemic control in critically ill patients and to compare the results with different routine glucose management protocols of three intensive care units (ICUs) across Europe (Graz, Prague, and London).
RESEARCH DESIGN AND METHODS—Sixty patients undergoing cardiac surgery (age 67 ± 9 years, BMI 27.7 ± 4.9 kg/m2, 17 women) with postsurgery blood glucose levels &gt;120 mg/dl (6.7 mmol/l) were investigated in three different ICUs (20 per center). Patients were randomized to either blood glucose management (target range 80–110 mg/dl [4.4–6.1 mmol/l]) by the fully automated model predictive control (MPC) algorithm (n = 30, 10 per center) or implemented routine glucose management protocols (n = 30, 10 per center). In all patients, arterial glucose was measured hourly to describe the glucose profile until the end of the ICU stay but for a maximum period of 48 h.
RESULTS—Compared with routine protocols, MPC treatment resulted in a significantly higher percentage of time within the target glycemic range (% median [min–max]: 52 [17–92] vs. 19 [0–71]) over 0–24 h (P &lt; 0.01). Improved glycemic control with MPC treatment was confirmed in patients remaining in the ICU for 48 h (0–24 h: 50 [17–71] vs. 21 [4–67], P &lt; 0.05, and 24–48 h: 65 [38–96] vs. 25 [8–79], P &lt; 0.05, for MPC [n = 16] vs. routine protocol [n = 13], respectively). Two hypoglycemic events (&lt;54 mg/dl [3.0 mmol/l]) were observed with routine protocol treatment. No hypoglycemic event occurred with MPC.
CONCLUSIONS—The data suggest that the MPC algorithm is safe and effective in controlling glycemia in critically ill postsurgery patients.
Low–Saturated Fat Dietary Counseling Starting in Infancy Improves Insulin Sensitivity in 9-Year-Old Healthy Children
Authors: Kaitosaari Tuuli , Rönnemaa Tapani , Viikari Jorma , Raitakari Olli , Arffman Martti , Marniemi Jukka , Kallio Katariina , Pahkala Katja , Jokinen Eero , Simell Olli 
Published: May 2006

OBJECTIVE—Insulin resistance is promoted already in childhood by obesity and possibly by high–saturated fat intake. We examined the effect of infancy onset biannually given dietary counseling on markers of insulin resistance in healthy 9-year-old children.
RESEARCH DESIGN AND METHODS—Healthy 7-month-old infants (n = 1,062) were randomized to the intervention (n = 540) and control (n = 522) groups. Each year, two individualized counseling sessions were organized to each intervention family. The purpose of counseling was to minimize children’s exposure to known environmental atherosclerosis risk factors. Homeostasis model assessment of insulin resistance (HOMA-IR) index, serum lipids, blood pressure, and weight for height were determined in a random subgroup of 78 intervention children and 89 control children at the age of 9 years.
RESULTS—Intervention children consumed less total and saturated fat than the control children (P = 0.002 and &lt; 0.0001, respectively). The HOMA-IR index was lower in intervention children than in control children (P = 0.020). There was a significant association between saturated fat intake and HOMA-IR. In multivariate analyses including saturated fat intake, study group, and other determinants of HOMA-IR (serum triglyceride concentration, weight for height, and systolic blood pressure), study group was, whereas saturated fat intake was not, significantly associated with HOMA-IR. This suggests that the beneficial effect of intervention on insulin sensitivity was largely, but not fully, explained by the decrease in saturated fat intake.
CONCLUSIONS—The long-term biannual dietary intervention decreases the intake of total and saturated fat and has a positive effect on insulin resistance index in 9-year-old children.
Diabetes and 30-Day Mortality From Peptic Ulcer Bleeding and Perforation
Authors: Thomsen Reimar W. , Riis Anders , Christensen Steffen , Nørgaard Mette , Sørensen Henrik T. 
Published: May 2006

OBJECTIVE— Diabetes may influence the outcome of complicated peptic ulcer disease, due to angiopathy, blurring of symptoms, and increased risk of sepsis. We examined whether diabetes increased 30-day mortality among Danish patients hospitalized with bleeding or perforated peptic ulcers.
RESEARCH DESIGN AND METHODS— This population-based cohort study took place in the three Danish counties of North Jutland, Viborg, and Aarhus between 1991 and 2003. Patients hospitalized with a first-time diagnosis of peptic ulcer bleeding or perforation were identified using the counties’ hospital discharge registries. Data on diabetes, other comorbidities, and use of ulcer-associated drugs were obtained from discharge registries and prescription databases. The Danish Civil Registry System allowed complete follow-up for mortality. The outcome under study was 30-day mortality in diabetic versus nondiabetic patients, adjusted for potential confounders.
RESULTS— We identified 7,232 patients hospitalized for bleeding ulcers, of whom 731 (10.1%) had diabetes. The 30-day mortality among diabetic patients was 16.6 vs. 10.1% for other patients with bleeding ulcers. The adjusted 30-day mortality rate ratio (MRR) for diabetic patients was 1.40 (95% CI 1.15–1.70). We also identified 2,061 patients with perforated ulcers, of whom 140 (6.8%) had diabetes. The 30-day mortality among diabetic patients was 42.9 vs. 24.0% in other patients with perforated ulcers, corresponding to an adjusted 30-day MRR of 1.51 (1.15–1.98).
CONCLUSIONS— Among patients with peptic ulcer bleeding and perforation, diabetes appears to be associated with substantially increased short-term mortality.
Disorders of Glucose Metabolism in Acute Stroke Patients
Authors: Matz Karl , Keresztes Katharina , Tatschl Claudia , Nowotny Monika , Dachenhausen Alexandra , Brainin Michael , Tuomilehto Jaakko 
Published: May 2006

OBJECTIVE—To determine the prevalence of disturbances in glucose metabolism in patients with acute stroke.
RESEARCH DESIGN AND METHODS—Consecutively admitted acute stroke patients (n = 286) were screened for glucose tolerance according to the standardized World Health Organization protocol in the 1st and 2nd week after the stroke event. In addition, we repeatedly measured fasting capillary blood glucose during the first 10 days.
RESULTS—Measurements were not performed or cancelled if patients were not fully conscious or had severe dysphagia or early complications that made transfers to other hospitals necessary (n = 48). Of the remaining 238 patients, 20.2% had previously known diabetes; 16.4% were classified as having newly diagnosed diabetes, 23.1% as having impaired glucose tolerance (IGT), and 0.8% as having impaired fasting glucose; and only 19.7% showed normal glucose levels. Another 47 patients (19.7%) had hyperglycemic values only in the 1st week (transient hyperglycemia) or could not be fully classified due to missing data in the oral glucose tolerance test. Patients with diabetes compared with nondiabetic subjects had more severe strokes (National Institutes of Health Stroke Scale [NIHSS] on admission: 7.2 ± 6.6 vs. 4.6 ± 3.1, 4.2 ± 4.4, and 3.7 ± 3.6 for IGT, transient hyperglycemia, and normoglycemia, respectively; P &lt; 0.001), a worse outcome (modified Rankin scale 0–1 at discharge: 40.2 vs. 54.4, 63.8, and 72.3% for IGT, transient hyperglycemia, and normoglycemia, respectively; P &lt; 0.001), and a higher rate of infectious complications (35.6 vs. 12.3, 21.2, and 4.2% for IGT, transient hyperglycemia, and normoglycemia, respectively; P &lt; 0.001). In the multivariate analysis, NIHSS on admission, female sex, and the occurrence of urinary tract infection were independently associated with newly diagnosed diabetes.
CONCLUSIONS—The majority of acute stroke patients have disorders of glucose metabolism, and in most cases this fact has been unrecognized. Diabetes worsens the outcome of acute stroke. Therefore, in the post–acute phase, an oral glucose tolerance test should be recommended in all stroke patients with no prior history of diabetes.
Cereal Fiber Improves Whole-Body Insulin Sensitivity in Overweight and Obese Women
Authors: Weickert Martin O. , Möhlig Matthias , Schöfl Christof , Arafat Ayman M. , Otto Bärbel , Viehoff Hannah , Koebnick Corinna , Kohl Angela , Spranger Joachim , Pfeiffer Andreas F.H. 
Published: May 2006

OBJECTIVE—Cereal fiber intake is linked to reduced risk of type 2 diabetes in epidemiological observations. The pathogenic background of this phenomenon is unknown. Based on recent findings, we hypothesized that intake of purified insoluble oat fiber may improve whole-body insulin sensitivity.
RESEARCH DESIGN AND METHODS—A randomized, controlled, single-blind, cross-over study was performed, and 17 overweight or obese subjects with normal glucose metabolism were analyzed. After consumption of nine macronutrient-matched portions of fiber-enriched bread (white bread enriched with 31.2 g insoluble fiber/day) or control (white bread) over a time period of 72 h, whole-body insulin sensitivity was assessed by euglycemic-hyperinsulinemic clamp. Energy intake was individually adjusted by providing standardized liquid meals. Hydrogen breath tests were performed to control for dietary adherence.
RESULTS—When analyzing the entire cohort, whole-body glucose disposal was improved after fiber consumption (M value 6.56 ± 0.32 vs. 6.07 ± 0.27 mg · min−1 · kg−1; P = 0.043). Thirteen subjects had increased hydrogen breath test concentrations after fiber consumption, indicating probable dietary adherence. Restricting analysis to these subjects, improvements in M value (6.85 ± 0.34 vs. 6.06 ± 0.32 mg · min−1 · kg−1; P = 0.003) and insulin sensitivity, expressed as M/I ratio (M value divided by mean serum insulin at steady state: 3.73 ± 0.23 vs. 3.21 ± 0.27; P = 0.02), after fiber consumption were more pronounced. Plasma lipids, serum magnesium, ghrelin, and adiponectin concentrations, as well as substrate utilization and body weight, were not significantly changed by fiber intake (P &gt; 0.15).
CONCLUSIONS—Increased insoluble dietary fiber intake for 3 days significantly improved whole-body insulin sensitivity. These data suggest a potential mechanism linking cereal fiber intake and reduced risk of type 2 diabetes.
Electrochemical Behavior of Dopamine at a Penicillamine Self‐Assembled Gold Electrode and its Analytical Application
Authors: Niu Ling Mei , Luo Hong Qun , Li Nian Bing 
Published: May 2006

AbstractThe fabrication and electrochemical characteristics of penicillamine (PCA) self‐assembled monolayer modified gold electrode were investigated. The self‐assembled electrode shows an obvious electrocatalytic activity for the oxidation of dopamine (DA). In phosphate buffer (pH 7.0), the peak current is proportional to the concentration of DA in the range of 8.0×10–6 ˜ 1.0×10–3 M by the cyclic voltammetry methods with the detection limits of 4.5×10–7 M. The PCA self‐assembled monolayer modified gold electrode can be applied to the determination of DA in practical injection samples with simplicity, rapidness, and accurate results.
Aggregation Behavior of Giant Amphiphiles Prepared by Cofactor Reconstitution
Authors: Boerakker Mark J. , Botterhuis Nicole E. , Bomans Paul H. H. , Frederik Peter M. , Meijer Emmo M. , Nolte Roeland J. M. , Sommerdijk Nico A. J. M. 
Published: May 2006

AbstractWe report on biohybrid surfactants, termed “giant amphiphiles”, in which a protein or an enzyme acts as the polar head group and a synthetic polymer as the apolar tail. It is demonstrated that the modification of horseradish peroxidase (HRP) and myoglobin (Mb) with an apolar polymer chain through the cofactor reconstitution method yields giant amphiphiles that form spherical aggregates (vesicles) in aqueous solution. Both HRP and Mb retain their original functionality when modified with a single polystyrene chain, but reconstitution has an effect on their activities. In the case of HRP the enzymatic activity decreases and for Mb the stability of the dioxygen myoglobin (oxy‐Mb) complex is reduced, which is probably the result of a disturbed binding of the heme in the apo‐protein or a reduced access of the substrate to the active site of the enzyme or protein.
Ce2[SeO3]3 and Pr2[SeO3]3: Non‐Isostructural Oxoselenates(IV) of the Light Lanthanoids.
Authors: Wontcheu Joseph , Schleid Thomas 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Chloro(trifluorophosphane)gold(I): [Au(PF3)Cl].
Authors: Schoedel Frauke , Bolte Michael , Wagner Matthias , Lerner Hans‐Wolfram 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Crystal Structure and Magnetic Properties of Ca2MnAlO5.5, an n = 3 Brownmillerite Phase.
Authors: Palmer Helen M. , Snedden Alan , Wright Adrian J. , Greaves Colin 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Substitution of Au or Hg into BaTl2 and BaIn2. New Ternary Examples of Smaller CeCu2‐Type Intermetallic Phases.
Authors: Dai Jing‐Cao , Corbett John D. 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Crystal Structure of a New Compound Er2MnW0.8O6.4 Phase.
Authors: Chen G. , Imagawa Y. , Satoh H. , Nakano H. , Kamegashira N. 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Rb6(InCo)2(Si9O26): A Mixed‐Metal Silicate Containing 20‐Membered‐Ring Silicate Single Layers with a Very Low Si:O Ratio.
Authors: Hung Ling‐I. , Wang Sue‐Lein , Chen Yen‐Hung , Lii Kwang‐Hwa 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Asymmetric Allylic Oxidation Reactions Catalyzed by a Chiral Nonracemic and C2‐Symmetric 2,2′‐Bipyridyl Copper(I) Complex.
Authors: Lyle Michael P. A. , Wilson Peter D. 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
[HP(HNCH2CH2)3N]NO3: An Efficient Homogeneous and Solid‐Supported Promoter for aza and thia‐Michael Reactions and for Strecker Reactions.
Authors: Fetterly Brandon M. , Jana Nirmal K. , Verkade John G. 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Isomerization of Propargylic Alcohols into α,β‐Unsaturated Carbonyl Compounds Catalyzed by the Sixteen‐Electron Allyl‐Ruthenium(II) Complex [Ru(η3‐2‐C3H4Me)(CO)(dppf)] [SbF6].
Authors: Cadierno Victorio , Garcia‐Garrido Sergio E. , Gimeno Jose 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Highly Efficient Methods for the One‐Pot Synthesis of β‐Substituted Enones.
Authors: Kerr William J. , Pearson Colin M. , Thurston Graeme J. 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Reduction of 1‐Nitrospiro[2.2]pentanecarboxylates: Convenient Synthesis of Novel Polyspirocylic Cyclopropane Amino Acids.
Authors: Yashin Nikolai V. , Averina Elena B. , Grishin Yuri K. , Kuznetsova Tamara S. , Zefirov Nikolai S. 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of Aryl‐Substituted 1,4‐Benzoquinone via Water‐Promoted and In(OTf)3‐Catalyzed in situ Conjugate Addition‐Dehydration of Aromatic Compounds to 1,4‐Benzoquinone in Water.
Authors: Zhang Hai‐Bo , Liu Li , Chen Yong‐Jun , Wang Dong , Li Chao‐Jun 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Formation of Conjugated Dienes by the Reaction of Titanocene Alkenylidene Complexes with Alkynes.
Authors: Shono Tomohiro , Hayata Yuki , Tsubouchi Akira , Takeda Takeshi 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Stereoselective Synthesis of Tetrahydrofuran by Diastereoselective [3 + 2] Cycloaddition Reaction of Chiral Allylsilane with α‐Keto Ester.
Authors: Akiyama Takahiko , Funaki Shinya , Fuchibe Kohei 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Regiocontrolled Synthesis of 1,2‐Diaryl‐1H‐imidazoles by Palladium‐ and Copper‐Mediated Direct Coupling of 1‐Aryl‐1H‐imidazoles with Aryl Halides under Ligandless Conditions.
Authors: Bellina Fabio , Cauteruccio Silvia , Mannina Luisa , Rossi Renzo , Viel Stephane 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
General Microwave‐Assisted Protocols for the Expedient Synthesis of Furo[3,2‐c]chromen‐4‐ones.
Authors: Wu Jie 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Baylis—Hillman Adducts Between Pyridine Carboxaldehyde Derivatives and Cyclic Enones.
Authors: Narender P. , Gangadasu B. , Ravinder M. , Srinivas U. , Swamy G. Y. S. K. , Ravikumar K. , Rao V. Jayathirtha 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of 2,3‐Dihydroimidazo[1,2‐b]isoquinoline‐5(1H)‐one and Derivatives.
Authors: Bollini Mariela , Asis Silvia E. , Bruno Ana Maria 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Facile Route for the Synthesis of Pyridazine Derivatives: Unexpected Pathway to Benzothiazole, Benzimidazole, and Triazole Derivatives.
Authors: El Rady Eman A. 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Cycloalkano[1′′,2′′,4,5;4′′,3′′:4′,5′]bis(pyrrolo[2,3‐c]pyrimido [5,4‐e]pyridazines): Synthesis, Structure and Mechanism of Their Formation.
Authors: Serduke Olga V. , Gulevskaya Anna V. , Pozharskii Alexander F. , Starikova Zoya A. , Profatilova Irina A. 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Facile One‐Pot Synthesis of 2‐Aryl‐4‐[2H‐2‐oxo‐[1]benzopyran‐3‐yl]‐2,3‐dihydro and 2,5‐Dihydro‐1,5‐benzothiazepines.
Authors: Rao V. Rajeswar , Reddy M. Madan Mohan 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Total Synthesis of Phorboxazole B.
Authors: Li De‐Run , Zhang Dong‐Hui , Sun Cai‐Yun , Zhang Ji‐Wen , Yang Li , Chen Jian , Liu Bo , Su Ce , Zhou Wei‐Shan , Lin Guo‐Qiang 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Terminal, Anionic Carbide, Nitride, and Phosphide Transition‐Metal Complexes as Synthetic Entries to Low‐Coordinate Phosphorus Derivatives
Authors: Cummins Christopher C. 
Published: May 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.