bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical application of reserved gastric tube in neuroendoscopic endonasal surgery for pituitary tumor
Authors: Chen Xi , Zhang Long-Yao , Wang Zhi-Feng , Zhang Yi , Yin Yu-Hua , Wang Xue-Jian 
Published: March 2024

BACKGROUND
The neuroendoscopic approach has the advantages of a clear operative field, convenient tumor removal, and less damage, and is the development direction of modern neurosurgery. At present, transnasal surgery for sphenoidal pituitary tumor is widely used. But it has been found in clinical practice that some patients with this type of surgery may experience post-operative nausea and vomiting and other discomforts.
AIM
To explore the effect of reserved gastric tube application in the neuroendoscopic endonasal resection of pituitary tumors.
METHODS
A total of 60 patients who underwent pituitary adenoma resection via the endoscopic endonasal approach were selected and randomly divided into the experimental and control groups, with 30 in each group. Experimental group: After anesthesia, a gastric tube was placed through the mouth under direct vision using a visual laryngoscope, and the fluid accumulated in the oropharynx was suctioned intermittently with low negative pressure throughout the whole process after nasal disinfection, during the operation, and when the patient recovered from anesthesia. Control group: Given the routine intraoperative care, no gastric tube was left. The number of cases of nausea/vomiting/aspiration within 24 h post-operation was counted and compared between the two groups; the scores of pharyngalgia after waking up, 6 h post-operation, and 24 h post-operation. The frequency of postoperative cerebrospinal fluid leakage and intracranial infection were compared. The hospitalization days of the two groups were statistically compared.
RESULTS
The times of postoperative nausea and vomiting in the experimental group were lower than that in the control group, and the difference in the incidence of nausea was statistically significant (P < 0.05). After the patient woke up, the scores of sore throat 6 h after the operation and 24 h after operation were lower than those in the control group, and the difference was statistically significant (P < 0.05). The number of cases of postoperative cerebrospinal fluid leakage and intracranial infection was higher than that of the control group, but there was no statistically significant difference from the control group (P > 0.05). The hospitalization days of the experimental group was lower than that of the control group, and the difference was statistically significant (P < 0.05).
CONCLUSION
Reserving a gastric tube in the endoscopic endonasal resection of pituitary tumors, combined with intraoperative and postoperative gastrointestinal decompression, can effectively reduce the incidence of nausea, reduce the number of vomiting and aspiration in patients, and reduce the complications of sore throat The incidence rate shortened the hospitalization days of the patients.
INFORMAL INSTITUTIONS AS A FACTOR OF ENTREPRENEURIAL ACTIVITY
Authors: Каминская А.А. 
Published: March 2024

Данное исследование посвящено анализу влияния неформальных институтов на предпринимательскую активность в странах с различным уровнем формальной институциональной среды. Автором рассматривается воздействие культурных ценностей, таких как индивидуализм, избегание неопределенности, дистанция власти, доверие, боязнь неудач, принятие риска и др. на предпринимательскую деятельность. Актуальность исследования обусловлена контекстом современного развития экономики, где роль культурных ценностей в предпринимательской деятельности становится все более значимой. С использованием эконометрических методов на международной выборке подтверждается связь между индивидуализмом, уровнем избегания неопределенности, принятием риска, потребностью в независимости и статусом предпринимателя с предпринимательской активностью. Важно отметить, что наблюдаемые взаимосвязи различаются в зависимости от уровня развития формальных институтов в стране. Результаты исследования позволяют глубже понять роль культурных ценностей в формировании предпринимательского поведения и их влияние в различных институциональных условиях. Полученные выводы о различиях в уровнях предпринимательской деятельности объясняются культурными факторами, которые могут быть использованы для разработки более эффективных стратегий поддержки предпринимательства в различных социокультурных контекстах.
This study is devoted to the analysis of the impact of informal institutions on entrepreneurial activity in countries with different levels of formal institutional environment. The author examines the impact of cultural values such as individualism, avoidance of uncertainty, distance of power, trust, fear of failure, risk taking, etc. on entrepreneurial activity. The relevance of the research is determined by the context of modern economic development, where the role of cultural values in entrepreneurial activity is becoming increasingly important. Using econometric methods, an international sample confirms the relationship between individualism, the level of uncertainty avoidance, risk acceptance, the need for independence and the status of an entrepreneur with entrepreneurial activity. It is important to note that the observed relationships vary depending on the level of development of formal institutions in the country. The results of the study provide a deeper understanding of the role of cultural values in shaping entrepreneurial behavior and their impact in various institutional settings. The findings on the differences in the levels of entrepreneurial activity are explained by cultural factors that can be used to develop more effective strategies to support entrepreneurship in various socio-cultural contexts.
PROBLEMS OF RUSSIA'S INTEGRATION INTO THE WORLD ECONOMY AND ITS ECONOMIC SECURITY
Authors: Есиков С.Н. 
Published: March 2024

В статье представлены результаты анализа проблем международной интеграции России в контексте обеспечения экономической безопасности. Выявлены барьеры интеграции, включающие низкую конкурентоспособность российских товаров, слабое развитие транспортных путей на востоке и экономическая дискриминация. В текущих условиях подчеркивается важность усиления взаимодействия российской экономики со странами ЕАЭС и БРИКС. Сделан вывод, что успешная интеграция России с дружественными государствами оказывает существенное влияние на развитие экономики и усиление внешнеполитических позиций. Автором выявлены ключевые факторы, являющиеся источниками рисков для экономической безопасность страны: санкции и ограничения, рост теневой экономики, отток капитала, а также зависимость от цен на сырьевые ресурсы. Предложены пути обеспечения экономической безопасности, включающие реиндустриализацию, импортозамещение, а также гибкие меры и повышения устойчивости национальной экономики России. Обосновано, что экономическая интеграция и сотрудничество с дружественными странами позволит сократить риски, связанные с обеспечением экономической безопасности России, обеспечить российским предприятиям доступ к международным рынкам и ресурсам, а также повысить их конкурентоспособность посредством обмена технологиями и опытом.
The article presents the results of the analysis of the problems of Russia's international integration in the context of ensuring economic security. Barriers to integration have been identified, including low competitiveness of Russian goods, poor development of transport routes in the east and economic discrimination. In the current conditions, the importance of strengthening the interaction of the Russian economy with the EAEU and BRICS countries is emphasized. It is concluded that the successful integration of Russia with friendly states has a significant impact on the development of the economy and the strengthening of foreign policy positions. The author identifies the key factors that put the country's economic security at risk: sanctions and restrictions, the growth of the shadow economy, capital outflow, as well as dependence on prices for raw materials. The ways of ensuring economic security, including reindustrialization, import substitution, as well as flexible measures and increasing the stability of the national economy of Russia, are proposed. It is proved that economic integration and cooperation with friendly countries will reduce the risks associated with ensuring Russia's economic security, provide Russian enterprises with access to international markets and resources, as well as increase their competitiveness through the exchange of technologies and experience.
Evaluation on Patient Triaging Pathway Strategy Guidelines for Cases with Elipidae Bite during COVID-19 Pandemic at Emergency Department
Authors: Ahmad Khusairi Zainul Ikhwan , Abu Bakar Nor Aroma , Raman Komalah , Abdul Kudus Mohammad Nasir , Mohd Nafiri Muhammad Hafiz , Hamzah Norhayati , Ismail Haslinda 
Published: March 2024

Emergency department (ED) typically practicing a triage system to classify patients into priority levels. Triage system is commonly used in crowded emergency rooms to determine which patient should be seen and treated immediately. Therefore, the objective of this study was to evaluate the effectiveness of triaging pathway strategies guidelines for critical cases seen in the Emergency Department during the COVID-19 outbreak. Emergency Department, Taiping Hospital is practicing triaging system which consist of two divisions; case with respiratory symptoms (SARI) and case with no symptom of respiratory impairment (NON SARI). One case report was selected to answer the study objectives. A patient with snake bite which presented at Emergency Department, Taiping Hospital with symptoms of numbness at bitten hand and complaint of difficulty to open the eyes and tachycardia noted. However, no shortness of breath or difficulty in breathing was reported. COVID-19 rapid screening done and patient were treated under Red Zone (Non SARI). Luckily patient survived and was stable with no reaction observed after Neuro Polyvalent Antivenom 50cc in 500cc normal saline in one hour commenced. This case report proved that patient triaging pathway strategy guidelines provided was effectively practiced by paramedic during managing critical cases at Emergency Department during COVID-19 outbreak. Researchers also recommended that other Emergency Department should be advised to practice an effective and appropriate triaging pathway strategy guidelines to save patient’s life.
DAKWAH ISLAM DI ERA GENERASI MILENNIAL
Authors: Luthfi Hidayah  
Published: March 2024

Pada zaman modern seperti sekarang ini, teknologi semakin berkembang
pesat. Gadget dan internet pun seakan sudah menjadi pujaan hati bagi generasi
millennial
.
Media sosial menjadi tren di kalangan generasi
millennial
. Dakwah harus
memanfaatkannya secara ma
ksimal. Jika tidak, arus dakwah kian melambat dan
ketinggalan zaman. Perkembangan teknologi komunikasi telah mengubah cara orang
berkomunikasi. Oleh karena itu, perlu adanya mengoptimalisasikan pemanfaatan media
baru dan strategi dakwah sesuai generasi
mil
lennia
. Mengingat segmentasi mad’u sangat
komplek dan beragam. Beberapa waktu yang lalu, Gus Miftah seorang pendakwah anti
-
mainstrem ramai diperbincangkan di sosial media yang memperlihatkan dirinya sedang
berdakwah serta mengajak bershalawat para pemandu
karaoke. Cara dakwah yang
dilakukan Gus Miftah tersebut tidaklah wajar, karena lokasi dakwahnya adalah sebuah
klub malam yang dianggap kotor atau tidak pantas untuk menerima dakwah. Kemudian
muncul pertanyaan, bagaimana strategi Gus Miftah dalam mengajak p
ara ahli maksiat
untuk menuju ke jalan yang benar? menggunakan metode dakwah apa yang cocok bagi
kaum marjinal.
Dakwah Media Sosial dalam Literasi Pesantren
Authors: Siti Mahmudah Yanti  
Published: March 2024

Hakikat dakwah media sosial literasi pesantren adalah mampu memberikan khazanah bagi seluruh lapisan masyarakat yang ingin mendalami ajaran agama Islam dan dapat menguatkan dakwah secara virtual agar tersampaikan dengan baik (secara tulisan atau lisan). Pesantren dalam eksistensinya memiliki fungsi kegiatan tafaqquhu fi ddin yaitu pengajaran, pemahaman, dan pendalaman ajaran agama Islam dan fungsi Indzar yaitu menyampaikan dan mendakwahkan ajaran agama Islam kepada masyarakat. Dengan memanfaatkan media sosial sebagai wadah dalam dakwah akan semakin mudah menyebarluaskan ajaran agama Islam secara universal. Pesantren harus mampu bersinergi membangun peradaban sesuai tuntutan agama Islam dan hadir dengan narasi positif yang tersebar melalui media sosial.
Peran Fisioterapi Pada Individu Dengan Hemiparesis Sinistra Post Stroke : A Case Study
Authors: Diajeng Sabina Purwagayatri  , Adnan Faris Naufal  , Nur Indah Swariningrum  
Published: March 2024

Introduction: Stroke occurs when the blood supply to the brain is blocked and blood vessels in the brain burst. The brain can't get the blood and oxygen it needs, so brain cells die. In this case, the patient complained of a feeling of weakness and heaviness in the left side of the body, which made it difficult for him to carry out everyday activities. Objective: To determine the role of physical therapy in individuals with left hemiparesis after stroke on muscle strength, spasticity, and functional ability using infrared intervention, electrical stimulation, and exercise therapy. Method: Subjective and objective examinations were carried out, followed by physiotherapeutic intervention in 3 weeks. Results: After physiotherapeutic intervention, the results showed an increase muscle strength using manual muscle testing (MMT) of the hip muscle group T1=2 to T3=2+, the knee muscle group T1=2 to T3=-3. Reduced muscle tone according to the Asworth scale in the shoulder area T1=1+ to T3=1, as well as functional ability according to the Barthel index with results from T1=65 to T3=70. Conclusion: Physiotherapeutic interventions using infrared, electrical stimulation, and exercise therapy can increase muscle strength, reduce spasticity, and improve functional ability in individuals with left-sided hemiparesis after stroke
Metode Pelaksanaan Pekerjaan Rigid Pavement Pada Proyek Preservasi Jalan Raya Kanor – Semambung Kabupaten Bojonegoro, Jawa Timur
Authors: Dewangga Andya Mahendra Putra  
Published: March 2024

Proyek Preservasi Jalan Raya Kanor – Semambung ini merupakan kegiatan yang berkaitan dengan peningkatan kenyamanan serta kelancaran dalam berlalu lintas. Hal ini dilakukan agar mempermudah Mobilitas Masyarakat yang bertempat tinggal di daerah tersebut. Dengan meningkatnya jumlah penduduk dan perkembangan suatu daerah, maka kebutuhan pada daerah tersebut pun akan bertambah juga, oleh karena itu diperlukan Peningkatan jalan. Peningkatan jalan Kanor - Semambung Bojonegoro, Jawa Timur ini merupakan jalan yang menghubungkan daerah Kanor menuju arah Semambung dengan panjang 4,375 km. Dengan adanya pembangunan jalan tersebut dapat menunjang kelancaran transportasi dan perekonomian yang mempermudah menuju daerah tersebut. Pada penulisan jurnal ini akan membahas mengenai bahan yang digunakan, alat yang digunakan, serta tahapan pada proses pekerjaan Rigid Pavement. Metode yang digunakan yaitu mengumpulkan studi literatur yang berkaitan dengan proses Rigid Pavement, serta mempersiapkan materi. Dari metode tersebut juga meliputi lokasi penelitian. Pengumpulan data dan pengolahan data pada penulisan ini didapatkan langsung melalui kegiatan magang di lokasi kegiatan proyek pada kurun waktu kurang lebih 5 bulan. Proses Rigid Pavement terdiri dari beberapa tahapan yaitu proses Perencanaan (Planning), Pemograman (Programming), Pelaksanaan Kegiatan (Activating), Pengendalian (Controlling). Bahan yang digunakan pada proses pengaspalan antara lain, Beton readymix, Agregat kelas A dan S dan lain-lain. Selain bahan juga ada alat dan bahan yang digunakan yaitu, Truck Mixer, Dump truck, Bekisting, Vibrator, dan Besi Wiremesh Ø 8 mm.
Studi Literatur Aspek Ekonomi, Sosial, dan Lingkungan Tanggung Jawab Sosial Perusahaan PT. ANTAM, Tbk.
Authors: Asri Utami  , Ahmad Saifudin Mutaqi  
Published: March 2024

Tanggung jawab sosial perusahaan (CSR) penting untuk dilakukan oleh perusahaan terutama oleh perusahaan yang kegiatan operasinya memiliki dampak negatif pada masyarakat dan lingkungan sekitar. CSR dianggap penting karena pada kenyataannya ada perusahaan yang memiliki hubungan yang tidak harmonis dengan masyarakat (konflik) karena masyarakat atau masyarakat setempat terganggu oleh kegiatan perusahaan itu. Namun, selain itu ada perusahaan yang memiliki hubungan tidak harmonis, ada juga perusahaan yang memiliki hubungan yang cukup harmonis dengan masyarakat karena perusahaan telah menerapkan CSR dengan baik.
Implementasi CSR dilakukan sebagai bukti fenomena tanggung jawab sosial yang dilakukan oleh perusahaan. Penelitian ini memberikan gambaran tentang pelaksanaan tanggung jawab sosial perusahaan PT. Antam, Tbk. diulas dalam literatur dari aspek ekonomi, sosial, dan isu lingkungan. Realisasi tanggung jawab sosial dibidang ekonomi diwujudkan PT. Antam, Tbk. dengan memberikan kontribusi nyata bagi masyarakat dan Pemerintah yang bertujuan untuk meningkatkan kemandirian ekonomi dan kesejahteraan sosial, selain memberikan kontribusi kepada Pemerintah melalui pembayaran pajak, royalti, dan penerimaan negara bukan pajak (PNBP) lainnya, sesuai dengan peraturan yang berlaku. Upaya untuk memerangi kemiskinan di wilayah operasional Perusahaan diwujudkan dalam Program Kemitraan (PK). Program ini berfokus pada komunitas pemberdayaan ekonomi dengan penyediaan bisnis bantuan modal dan/atau modal investasi. PT. Antam, Tbk. memegang pandangan bahwa CSR itu penting karena selain membangun citra positif bagi perusahaan, juga dilakukan untuk mensejahterakan masyarakat sehingga ada hubungan yang harmonis antara perusahaan dengan masyarakat karena masyarakat adalah bagian dari pemangku kepentingan Antam.
Redesain Visual Identity Azyanu Batik
Authors: Hidayatul Hasanah  , Fauzan Aulia  
Published: March 2024

Azyanu Batik is an MSME engaged in the field of batik art based on local Minangkabau culture with "1000 Rumah Gadang" batik motifs which was founded by Zulmi Aryani since 2021, having its address at Muara Labuh, Solok Selatan Regency, West Sumatra Province. In this case, Azyanu Batik already has a visual identity but has not applied design principles and logo criteria to the fullest. The purpose of this design is to redesign Azyanu Batik's visual identity by applying design principles and good logo criteria as an effort to increase brand awareness and Azyanu Batik's image. The design method used is the 4D method, consisting of 4 stages, namely Define, Design, Develop, and Disseminate. While the design analysis used is through SWOT analysis. Azyanu Batik's visual identity redesign will be implemented into the main media and applicable media that can support the effectiveness of the visual identity created.
A proteção do consumidor superendividado à luz do direito ao desenvolvimento
Authors: Brasil Ana Larissa da Silva , Rodrigues André Angelo , Bandeira João Adolfo Ribeiro 
Published: March 2024

O presente artigo traz uma análise do Direito Humano ao Desenvolvimento como mecanismo de proteção coletiva dos consumidores superendividados. Esse direito está previsto na Declaração sobre o Direito ao Desenvolvimento de 1986 da Organização das Nações Unidas (ONU), refletindo o esforço de materializar-se, não através de leis, mas sim por meio de políticas públicas e diretrizes que promovam o desenvolvimento com a participação das pessoas nesse processo. A problemática propõe analisar em que medida o Direito Humano ao Desenvolvimento é capaz de promover a proteção dos superendividados. Primeiramente, são expostos os pontos essenciais sobre o conceito de Direito Humano ao Desenvolvimento, demonstrando sua origem e aplicabilidade nas diversas esferas; após, é demonstrada a contextualização com a realidade de consumidores em estado de superendividamento, ou seja, pessoas físicas incapazes de fazerem frente às suas dívidas atuais e futuras, ainda que de boa-fé, restando prejudicado o mínimo existencial e sua dignidade, resultando em exclusão social. Verificando a abrangência da proteção coletiva ao superendividamento através da interpretação das políticas nacionais e internacionais vigentes à luz do Direito Humano ao Desenvolvimento, tornando o direito humano ao consumo realizável. A pesquisa é bibliográfica e qualitativa, baseada nos principais autores relacionados à temática do Direito Humano ao Desenvolvimento e nas declarações internacionais e políticas públicas vigentes para proteção dos consumidores.
Evaluation of the anti-trypanosoma activity of alkaloids from Pilocarpus microphyllus by molecular docking: A search for new drugs for Chagas disease
Authors: Nogueira Silvania Siqueira , Sousa Paulo Sérgio de Araújo , Fochesato Mariana , Rocha Jefferson Almeida , Meirelles Ana Clara de Sousa , Veras Leiz Maria Costa 
Published: March 2024

Trypanosoma cruzi and Trypanosoma brucei, respectively, transmit the neglected tropical diseases (NTDs) Chagas disease and sleeping sickness. They cause symptoms that are harmful to public health. Treatment often has adverse effects, including high toxicity and neurosensory disorders. Studies aimed at developing pharmacological technologies are essential. In this study, we performed computational simulations based on in silico predictions. The amino acid sequence of the proteins for both parasites, T. cruzi and T. brucei, and their three-dimensional (3D) structures were obtained and drawn using the UniProt and Swiss model servers, respectively; later, they were used for in silico molecular docking studies. The GaussView software was used to get the two-dimensional (2D) and three-dimensional (3D) ligands of epiisopiloturine, epiisopilosine, pilosine, isopilosine, macaubine, and pilocarpine. To perform the optimization and frequency calculations of the alkaloids, the Gaussian 09w software and the Density Functional Theory (DFT) method were used with the hybrid functional B3LYP and the STO-3G support base. All the output files generated after the calculations were used to create the input files for the bond energy calculations. For the molecular docking studies, we have evaluated the side-ligands protein interactions and antiparasitic activity of the ligands. The anti-Trypanosomatidae potential of alkaloids extracted from Pilocarpus microphyllus “jaborandi” were evaluated by molecular docking. The results of the interactions of the 6 alkaloids: isopilosine, epiisopiloturine, epiisopilosine, pilocarpine, macubine and pilosine, with the proteins trypanothione reductase, sterol 14-alpha demethylase, phosphoinositide phospholipase c, farnesyl pyrophosphate synthase, nitroreductase, from the parasites T. cruzi and T. brucei, demonstrated that for 5 of them, the simulations showed minimums energy to be characterized as reactions that occur in biological systems spontaneously. For trypanothione reductase-epiisopilosine for both parasites, the alkaloid was observed to bind to the amino acid Glu467 through hydrogen bonds. For phosphoinositide phospholipase C-epiisopilosine, parameter values found were -8.2 Kcal.mol-1, only the amino acid Asn262 had interaction through hydrogen bonding. Other hydrophobic interactions were also observed between the proteins and epiisopilosine. Regarding the results of the alignment of amino acid sequences for both parasites, it was found a similarity of 83.30% and 52.38% between the nucleotide sequences of T. cruzi and T. brucei for trypanothione reductase and phosphoinositide phospholipase C, concluding that the best candidate for therapy against Chagas disease and sleeping sickness would be epiisopilosine alkaloid.