bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peroxiredoxin 6 maintains mitochondrial homeostasis and promotes tumor progression through ROS/JNK/p38 MAPK signaling pathway in multiple myeloma
Authors: gao dandan , Lv Yang , Hong Fei , Wu Dong , Wang Ting , Gao Gongzhizi , Lin Zujie , Yang Ruoyu , Hu Jinsong , He Aili , Zhang Pengyu 
Published: March 2024

Abstract

Peroxiredoxin 6 (PRDX6) is one of the Peroxiredoxin family members with only 1-Cys, using glutathione as the electron donor to reduce peroxides in cells. PRDX6 has been frequently studied and its expression was associated with poor prognosis in many tumors. However, the expression of PRDX6 in multiple myeloma (MM) and its relevance with MM remain unclear. In our study, we found that PRDX6 was overexpressed in MM patients. Its high expression was inversely correlated with prognosis but positively correlated with the levels of β2-microglobulin (B2M), lactate dehydrogenase (LDH), and ISS stage of MM patients. Further, the knockdown of PRDX6 promoted MM cell lines (RPMI 8226, MM.1S, and U266) apoptosis significantly. Mechanically, PRDX6 serves as an anti-oxidative enzyme, and its deficiency led to over-accumulation of reactive oxygen species (ROS), resulting in oxidative stress, following the activation of MAPK signaling pathway, which manifested as phosphorylation of JNK and p38. Then, the expression of BAX and Bcl2 was imbalance, and the cascade cleavage of PARP and caspase3 was increased, ultimately triggering cell apoptosis. In addition, oxidative stress decreased mitochondrial membrane potential (MMP), reduced gene expression levels of oxidative phosphorylation (OXPHOS), and increased in the density of mitochondrial crumpling, leading to mitochondrial structural abnormalities and dysfunction. Furthermore, PRDX6 deficiency combined with bortezomib induced a robust anti-tumor effect in MM cell lines. Finally, in vivo experiments also showed that the knockdown of PRDX6 inhibited tumor growth of tumor-bearing mice. Collectively, PRDX6 protects MM cells from oxidative damage and maintains mitochondrial homeostasis. And targeting PRDX6 is an attractive strategy to enhance the anti-tumor effect of bortezomib in MM.
Video-Assisted Thoracic Surgery (VATS) or Open Thoracotomy in Management of Pulmonary Hydatid cysts; A Randomized Controlled Trial
Authors: Kakamad Fahmi 
Published: March 2024

Abstract

Introduction: Pulmonary hydatid cysts, caused by Echinococcus Granulosus larvae, pose a significant health threat in livestock-raising regions, leading to respiratory symptoms. Surgical excision, involving open thoracotomy and video-assisted thoracoscopic surgery (VATS), is the primary treatment, yet their comparative effectiveness lacks robust evidence. The objective of this study is to compare outcomes of pulmonary hydatid cyst surgery using VATS and ThoracotomyMethods: We conducted a randomized controlled trial (RCT) with 50 patients to compare open thoracotomy and VATS for pulmonary hydatid cysts. Randomization was performed, and data collectors were blinded. Descriptive statistics and regression analysis were used to assess baseline characteristics and adjust for potential confounders.Results: Baseline characteristics were well-balanced between groups. VATS patients experienced reduced postoperative pain and a faster return to work compared to open thoracotomy. Correlation analysis revealed a moderate negative correlation between VATS and postoperative pain scores, as well as time to return to work. Age, gender, smoking, comorbidities, cyst number, and size showed limited correlations.Conclusion: This pilot RCT suggests VATS may offer advantages in reducing postoperative pain and hastening return to work. Larger studies are required for comprehensive clinical guidance.
Hurricane Ida’s blackout-heatwave compound hazard risk in a changing climate
Authors: Lin Ning , Feng Kairui , Gori Avantika , Xi Dazhi , Ouyang Min , Oppenheimer Michael 
Published: March 2024

Abstract
The emerging tropical cyclone (TC)-blackout-heatwave compound hazard under climate change are not well understood. In this study, we employ future projections of TCs, sea levels, and heatwaves, in conjunction with power system resilience modeling, to evaluate historical and future TC-blackout-heatwave compound hazard risks in Louisiana, US. We find that the return period for a compound hazard event comparable to Hurricane Ida (2021), with approximately 35 million customer hours of simultaneous power outage and heatwave exposure in Louisiana, is around 278 years in the historical climate (1980-2005). Under the emissions scenario SSP5 8.5 (SSP2 4.5), this return period may decrease by a factor of ~17×(10x) to 16.2 (28.4) years in the future climate (2070-2100). The significant increase in risk can be primarily attributed to projected escalations in heatwaves, which result in an approximate 5(2)-fold decrease in compound hazard return period, and in TC activity, which cause an estimated 2(1)-fold decrease in the return period. The findings contribute to our knowledge of and adaptation to compound climate hazards.
Research on ghost suppression and extraction method of towed streamer seismic data based on Green's theory
Authors: Xu Weichen , Wang Xiangchun , Nie Bing , Liu Zhendong 
Published: March 2024

Abstract

In marine seismic exploration, streamer seismic acquisition technology is crucial for the investigation and assessment of oil and gas reservoirs. However, the presence of the free surface leads to the generation of ghost waves, which introduce a series of notches in the seismic data spectrum and loss of low-frequency energy. This reduces the resolution of the seismic profile and significantly degrades the quality of the imaging. Moreover, the effectiveness of ghost wave suppression in actual data can only be judged in the frequency domain and cannot be proven in the time domain. Therefore, this study employs Green's theory to suppress ghost waves and, building on this foundation, proposes and derives a method for ghost wave extraction based on Green's theory. The physical significance and effectiveness of the method are verified from a one-dimensional perspective. A workflow for ghost wave suppression and extraction tailored for offshore streamer data has been successfully established. To improve computational efficiency, the integration region is dynamically partitioned based on the particularities of the Green's function, which substantially reduces the computational load while ensuring the accuracy of the results. The processing results of simulated and field data demonstrate that the method can effectively suppress and extract ghost waves, and the extracted ghost waves lay the foundation for subsequent studies on the impact of sea surface undulations on imaging results.
Four-way decomposition of the effects of nutrient supplement and physical exercise on depression among older Chinese: A nationwide cross-sectional analysis
Authors: Huang Shuna , Guo Jianhui , Jiang Renquan , Ma Ke , Lin Fuxin , Li Huangyuan , Kang Dezhi , Wu Siying 
Published: March 2024

Abstract

Background Studies on the associations between nutrient supplement, physical exercise, and depression among persons 65 years and older in China are still lacking. We aimed to investigate the association between nutrient supplement and depression and to explore the role of physical exercise in this association.Methods A total of 8,427 older Chinese adults from the Chinese Longitudinal Healthy Longevity Survey were included in this study. The Center for Epidemiologic Studies Depression Scale was used to assess participants' depression, and nutrient supplement and physical exercise were evaluated using self-reports. Linear regression and logistic regression were performed to explore the association between nutrient supplement and depression, and a four-way decomposition method was used to explore the effects of nutrient supplement and physical exercise on depression.Results A total of 26.2% of participants suffered from depression. Prior to decomposition, multivariable linear regression and logistic regression models showed that older adults who received nutrient supplement had lower depression score (β: -0.704; 95% CI: -1.004, -0.404) and a lower risk of depression (OR: 0.710; 5% CI: 0.564, 0.894), especially for calcium and multivitamins. Four-way decomposition analysis suggested that physical exercise mediates the associations between nutrient (protein, calcium, iron, zinc, multivitamins, vitamin A/D, docosahexaenoic acid, and others) supplement and depression (all P < 0.05).Conclusions Nutrient supplement was associated with inverse depression, and the reason why this association existed could be partly explained by the mediating effect of physical exercise.
Title：Cross-sectional Examination of the Association Between Life's Essential 8 Score and Overactive Bladder——NHANES 2005-2018
Authors: Li Zehao , Liu Xiangliang , Li Yuguang , Chen Xinqiao , Liu Ziming , Gao Xiaoxue , Cui Jiuwei 
Published: March 2024

Abstract

Objective
Life's Essential 8 (LE8) is an emerging composite metric of cardiovascular health encompassing diet, physical activity, smoking, sleep, weight, cholesterol, blood glucose, and blood pressure. Mounting evidence suggests lifestyle factors may play an important role in overactive bladder (OAB), however the link between LE8 and OAB remains unexplored. We aimed to examine the correlation between the two.
Methods
We analyzed data on 23,187 individuals from the 2005–2018 National Health and Nutrition Examination Survey (NHANES). Participants were stratified into low, moderate and high LE8 groups. Logistic regression examined the association between LE8 and OAB. Restricted cubic splines (RCS) and weighted quantile sum (WQS) regression further probed this relationship.
Results
Higher LE8 scores were associated with lower OAB risk, independent of covariate adjustment. The inverse correlation between LE8 and OAB was validated by RCS and WQS analyses. Of LE8 components, glycemic control conferred the greatest contribution.
Conclusions
Higher LE8 scores may be protective against OAB. Optimization of cardiovascular health metrics could represent a novel OAB prevention strategy.
Intranasal Racemic Ketamine Maintenance Therapy for Patients with Treatment-Resistant Depression: A Naturalistic Feasibility Study
Authors: Halpape Katelyn , Pashovitz Raelle , Wanson Annabelle , Hooper Monika , Peters Evyn 
Published: March 2024

Abstract

Background
Ketamine is a promising therapy for treatment-resistant depression due to its rapid onset, although benefits are often transitory, with patients needing maintenance therapy to prevent relapse. Most data supporting ketamine for treatment-resistant depression refers to the intravenous route of administration, leaving alternative routes lacking in data, especially as maintenance regimens. Moreover, the safety of ketamine maintenance therapy is poorly defined. This report aims to describe and evaluate a novel hospital-to-outpatient intranasal racemic ketamine maintenance therapy program.
Methods
This was an observational program evaluation study. Participants were adult inpatients with treatment-resistant depression who had been successfully treated with intranasal racemic ketamine in hospital and were being referred for outpatient maintenance therapy with an intranasal racemic ketamine spray, administered at a specialized community treatment centre. Effectiveness was assessed with the Self-Report Quick Inventory of Depressive Symptomatology, the Quality of Life Scale, and the Clinical Global Impression-Improvement scale.
Results
Five patients were enrolled, completing up to 14 treatment sessions over 192 days. The mean dose administered throughout treatment was 220 mg (100 to 400 mg). All patients benefited from ketamine as evidenced by decreased (or stable) depressive symptoms and increased (or stable) quality of life. There were no serious adverse events or discontinuations due to adverse effects. Reported adverse effects included anxiety and nausea. Slight blood pressure increases were seen during treatment, none of which required intervention.
Conclusions
Intranasal racemic ketamine maintenance therapy for treatment-resistant depression appeared to be feasible and well tolerated, although limited effectiveness conclusions can be drawn from this small pilot study. Further investigations regarding the safety and effectiveness of intranasal ketamine maintenance therapy are warranted.
On the investigation of microtructure, microhardness and tribological behavior of Ti-6Al-4V nitrided by pulse Nd-YAG Laser irradiation
Authors: ESSOUSSI Hamza , BOUGUERAA Fatima zahra , ETTAQI Said 
Published: March 2024

Abstract

The purpose of this paper is to evaluate the microhardness and characterize the microstructure of a Ti-6Al-4V alloy nitrided with a pulsed Nd-YAG laser under nitrogen gas flow. The Ti alloy surface was irradiated and melted at various laser scanning speeds. The phase analysis by X-ray diffraction for different irradiation conditions, revealed the formation of three phases: α-Ti, TiN, and TiN0.3. The results revealed that the microscopic analysis using optical and scanning electron microscopies revealed the presence of dendritic microstructure in both the laser-melted and nitreded zones, with TiN dendrites concentrated near the treated alloy's surface. Moreover, the wear of nitrided samples was examined using a pin-on-disk tribometre, the results revealed that the thickness of the TiN nitride layer (2 to 8 μm) affected the morphology of wear tracks.
Differentiating Immune Checkpoint Inhibitor-Related Pneumonitis From COVID-19 Pneumonia Using a CT-based Radiomics Nomogram
Authors: Yang Fengfeng , Li Zhengyang , Yin Di , Jing Yang , Zhao Yang 
Published: March 2024

Abstract

Objectives This study aimed to develop and validate a radiomics nomogram that effectively distinguishes between immune checkpoint inhibitor-related pneumonitis (CIP) and COVID-19 pneumonia using radiographic imaging features.
Methods We included 97 patients in this study, identifying 269 pneumonia lesions—159 from COVID-19 and 110 from CIP. The dataset was randomly divided into a training set (70% of the data) and a validation set (30%). We extracted radiomics features from corticomedullary and nephrographic phase-contrast computed tomography (CT) images, constructed a radiomics signature, and calculated a radiomics score (Rad-score). Using these features, we built models with three classifiers and assessed demographics and CT findings to create a clinical factors model. We then constructed a radiomics nomogram that combines the Rad-score with independent clinical factors and evaluated its performance in terms of calibration, discrimination, and clinical usefulness.
Results In constructing the radiomics signature, 33 features were critical for differentiating between CIP and COVID-19 pneumonia. The support vector machine classifier was the most accurate of the three classifiers used. The Rad-score, gender, lesion location, radiological features, and lesion borders were included in the nomogram. The nomogram demonstrated superior predictive performance, significantly outperforming the clinical factors model in the training set (AUC comparison, p = 0.02638). Calibration curves indicated good fit in both training and validation sets, and the nomogram displayed greater net benefit compared to the clinical model.
Conclusion The radiomics nomogram emerges as a noninvasive, quantitative tool with significant potential to differentiate between CIP and COVID-19 pneumonia. It enhances diagnostic accuracy and supports radiologists, especially in overburdened medical systems, through the use of machine learning predictions.
Liver abscess in the caudate lobe caused by Klebsiella pneumoniae: a rare case report
Authors: Cheng lingxia , LI Lei , Yongzao Liu , Cheng Wei , XU Ping 
Published: March 2024

Abstract

Background Klebsiella pneumoniae (K. pneumoniae) liver abscesses are more likely to appear as single abscess cavity to involve single lobe of the liver, the right lobe affected more commonly. Liver abscess in the caudate lobe is rarely reported.
Case presentation A 53-year-old man with chills and an intermittent high fever for the previous five days was admitted to our hospital. He had stable vital signs other than a tachycardia and fever at the time of presentation. Physical examination revealed tenderness over the right abdomen was elicited. The blood test showed a significant increase in C reactive protein (234.35mg/L), procalcitonin(57.62ng/mL), white blood cell counts (17.77×109/L ) and cLac(2.9mmol/L). His platelet count was 18×109/L. Computed tomographic (CT) scan of the lung demonstrated that there were multiple nodules and patchy shadows in each lobe of both lungs. A low-density area was observed in the caudate liver lobe on the liver CT scan. Klebsiella pneumoniae was isolated from sputum, urine and blood. With the suspicion of liver abscesses, invasive liver abscess syndrome (ILAS) and septic shock. The patient was successful treated with empirical antibiotics. He returned to close to his premorbid function.
Conclusion This is the first detailed report of liver abscess in the caudate liver lobe caused by K. pneumoniae.
Estimation of Absolute Abundance in Small Mammals. Let a Line Has an Area.
Authors: Shchipanov Nikolay A. , Kalinin Alexey A. 
Published: March 2024

Abstract
Small mammals play an important role in ecosystems. Changes in their numbers make it possible to monitor environmental changes, and robust estimates of population density is crucial. Capture-mark-recapture (CMR) on grid, an established method for estimating small mammal population density, is costly and labor-intensive. The cost of the survey can be reduced by reducing observation time, as well as by increasing sample size by arranging traps in a line. Using our 9-yers data obtained on grid we test whether relative abundance indices calculated over shorter time periods correctly reflect population density. We also propose a method for calculating population density using data obtained by CMR on lines (since the grid can be viewed as a series of independent lines) by estimating the spatial activity of animals. It was found that all the indexes calculated for grid and lines were in good agreement with population density on greed, and the scale of both interspecies and inter-annual differences in indexes and density was similar. Although indexes significantly correlated with population density since 3rd day, reliability of the indexes increased over the time of observations (R2 > 0.79 since 7th day). The population density calculated from the lines using the proposed method was in good agreement with the actual density recorded on the grid (R2 > 0.9). We could recommend using the indexes to estimate inter-annual changes in population abundance and community structure at the same area under invariant trapping protocol with invariant time of the trapping sessions. Density calculated on lines requires long-term study, but it is a universal estimate, and could be used when rough assessment of absolute abundance is needed.
Models analyzing the response of the adhesive joint between FRP and concrete: comparative analysis
Authors: Zhelyazov Todor 
Published: March 2024

Abstract
Fiber-reinforced polymers (FRP) for structural elements’ strengthening and rehabilitation are increasingly gaining popularity because of their proven efficiency and ease of application. The response of the adhesive joint formed between the FRP and concrete is a crucial factor for the overall behavior assessment of FRP structures. The contribution aims to provide a background for a model recently proposed by the author and designed to analyze the behavior of the adhesive joint between the FRP and concrete. The presented study reviews models based on the fracture mechanics approach to obtain a reference point needed to assess the output provided by an algorithm utilizing a damage-based model for the concrete and an empirical-based procedure for the loss of bond action. The analysis of the interface crack propagation is a complex task involving the consideration of several interacting mechanisms. Typically, model validation is performed via a comparison against experimental data. However, additional insights into the involved phenomena can be provided by comparing the results of various applicable models.
Identification and Characterization of Co-localized Expressed Sequence Tags (ESTs) underlying Putative Candidate Genes in Rice (Oryza sativa)
Authors: Zote Rahul , Dhawale Ramesh , Upadhye Vijay , Soni Mukesh , Hajare Sunil. T. 
Published: March 2024

Abstract
Rice (Oryza sativa L.) is a “Global Grain” cultivated widely across the world feeding millions of mankind. Rice as a grain rich in iron and zinc content is a polygenic complex trait having additive effect of multiple genes thus identification of Quantitative trait loci (QTLs) can lead to develop Fe/Zn rich rice using marker assisted breeding techniques. Several QTLs for the grain micronutrient contents have been identified and mapped on rice chromosome but their refinement and genetic dissection are yet to truly understand. Therefore, present study was conducted to identify and validate candidate gene based QTLs specific markers related to GPC and micronutrient content in rice to identify novel microsatellite markers within known QTLs controlling grain Fe and Zn content. Co-segregation analysis was performed with the F6 mapping population derived from a cross between rice cultivar Swarna x Moroberekan. The grain Fe content ranged from 9.68 to 19.98 µg/g with an average of 16.87 µg/g and grain Zn content ranged from 15.85 to 20.84 µg/g with an average of 25.76µg/g among the 73 homozygous rice mapping population. Similarly the grain protein content ranged from 5.34–7.18% with an average of 9.23%. Out of 1063 novel SSRs loci present within the 5 QTL regions, 161 Class I SSRs with 2–6 nt long repeat motifs and 12–80 nt repeat lengths were identified. On the basis of position of metal related transporter or membrane transporter genes primers were designed for 22 novels Class- I SSR and validated in the parents for their polymorphism. Among them, only 18 markers were found to be polymorphic. Out of 18 polymorphic SSRs, only five markers were significantly associated to grain iron and zinc contents. The allelic segregation analysis indicated that parent Swarna contributed about 60.6% whereas, parent Moroberekan contributed about 34.32% of total amplified alleles on an average. The identification of specific novel microsatellite markers in this study will help for marker-assisted breeding of grain micronutrient content in rice.