bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimization of Real-Time Power Grid Measurement Data Scheduling Based on Genetic Algorithms
Authors: Fang Bin , Zhu Shi , Zhu Hongyu , Zhang Ziqian , Tao Ye , Sheng Yubin 
Published: February 2025

Abstract
An increasing demand of real-time monitoring and data analysis for the power grid, is facing challenges from the processing rate of massive real-time measurement data such as voltage, current and power from billions of sensors. To guarantee process rate, many measurement data scheduling method had been studied, while the problem for the balance of realtime requirement and load balance has not been solved well, which leads to uneven load distribution and data congestion. Thus, this paper proposed a measurement data scheduling method based on genetic algorithm. The proposed method considers the characteristics of historical measurement data, task allocation matrix, and creates an adaptive parameter iterative solution based on using genetic algorithm. The results show that the proposed method can achieve appreciate load balance with time latency guarantee.
A Comparative Study of Inference Models Based on Image Recognition
Authors: Zhao Deling 
Published: February 2025

Abstract
Due to the limitation of web-side processing capabilities, the existing mainstream inference models adopt the client-to-server operation mode, and the emergence of WebAssembly has brought opportunities for the client to run the inference model alone for image recognition, and soon, the browser will fully support the standard. Therefore, on the basis of image recognition, this paper runs the mainstream inference model on the client and server side, and then compares the inference rate of different inference models at different batch sizes and the inference efficiency of the same inference model on the client and server side, conducts a large number of comparative experiments to record the experimental results, and then uses the method of averaging the experimental data to obtain a set of reliable experimental conclusions. Experimental results show that the performance of server-side TensorRT is better than other models under the same configuration conditions, ONNXRuntime is better than PyTorch in small batches, and PyTorch's performance improvement in accuracy has more room for optimization. The results of web-side experiments show that the inference model has a large difference in GPU usage, ONNXRuntime shows a greater performance advantage in the efficiency of GPU inference, while TensorRT will show better performance with the increase of batch. Compared with server-side inference, web-side inference shows stronger stability because it relies less on network transmission, so it can be preferred to direct inference when the batch is small, and server inference is preferred when the client configuration does not meet the conditions.
Getting Effect Prediction Model of CVTPD-PSL Technology Based on Artificial Neural Network
Authors: Zhang Caizhen , Li Zongzhi , Wang Zaixing 
Published: February 2025

Abstract
In view of technology characteristic of Continuously Variable Phosphorous Getting Process Using a Porous Silicon Layer (PSL-CVTPDG), a prediction model based on Artificial Neural Network(ANN) is put forward for predicting effect of PSL-CVTPDG process. Establish, train, test and verify as long as simulation of the prediction model were finished by means of ANN function in MATLAB. Experimental results show that the prediction and actually measured values are very close to, the output follows the tracks of the expectation value very well, which reflects that the ANN is an effective method for predicting the gettering effect of porous silicon materials.
Deformation, alteration and implicit 3D geomodelling of deposit-scale controls of vein-hosted copper mineralization of the Frontier Mine, Democratic Republic of Congo
Authors: Fourie Heike , Kisters Alexander , Basson Ian James 
Published: February 2025

Abstract
The structurally controlled, vein-hosted copper deposit of the Frontier Mine is distinct from the vast majority of sediment-hosted, stratiform Cu(-Co) deposits of the Zambian Copperbelt. Successively emplaced vein sets document the close interplay between the progressive structural evolution of the deposit, recording northeast-southwest shortening, and associated hydrothermal fluid flow and alteration (albitization). The deposit is hosted by greenschist-facies metasedimentary rocks of the Mwashya Subgroup in the first-order hinge zone of a regional-scale, refolded, recumbent fold (F1/F2). Early bedding/S1-parallel veins (Vein Set 1) formed during layer-parallel shearing and the onset of recumbent folding (F1). This early vein generation is relatively poorly mineralized, but was associated with a near-pervasive, bedding-parallel albitization and replacement of the mainly metapelitic wall rocks. The reaction hardening process promoted brittle deformation during the subsequent upright refolding (F2) of the rocks and the formation of a second generation of highly mineralized, saddle-reef type veins (Vein Set 2) in the hinges of particularly upright F2 folds (F1/F2). The controls of Vein Set 2 by fold hinges defines the overall shoot-like geometry of the orebody, parallel to the SE-plunging folds. The subhorizontal orientation and brecciated textures of a subsequent Vein Set 3 underline the formation of veins through continued northeast-southwest shortening of the brittle wall rocks during the lock up of the refolded first-order fold. The overprinting and structural relationships between vein sets, alteration and the regional fold structures signify a syn-tectonic, long-lived, multi-phase mineralization history during the Lufilian Orogeny.
Improved FAPI-radiopharmaceutical pharmacokinetics from the perspectives of a dose escalation study
Authors: Bilinska Adrianna , Ballal Sanjana , Bal Chandrasekhar , Läppchen Tilman , Pilatis Eirinaios , Menéndez Elena , Moon Euy Sung , Martin Marcel , Rösch Frank , Rominger Axel , Gourni Eleni 
Published: February 2025

Abstract

Purpose
This study explores the use of fibroblast activation protein inhibitors (FAPI) targeting radiopharmaceuticals as a new approach for pan-cancer treatment, focusing on key factors affecting their effectiveness. We hypothesized that adjusting the administered radiotracer dose one could enhance the tumor-to-background ratios.

Methods
In a dose-escalation study with PC3 xenografts, all radiotracers were administered at doses between 10 and 1500 pmol, followed by biodistribution and PET/CT imaging. Their selectivity towards FAP, PREP, and DDP4, along with their stability in vivo, was assessed by biodistribution and metabolite analysis, respectively. Organ FAP expression was quantified using qPCR, and circulating FAP (sFAP) levels were measured in mouse and human blood samples via ELISA. Proof-of-principle human studies were also conducted.

Results
Increasing the dose from 10 to 600 pmol significantly reduced blood uptake and enhanced tumor uptake, optimizing their in vivo performance. All radiotracers showed peak efficacy at 350–600 pmol, with altered pharmacokinetics beyond 600 pmol. Biodistribution studies validated the in vivo selectivity of all radiotracers towards FAP, even in the presence of PREP and DPP4 inhibitors, while they demonstrated remarkable stability in vivo. FAP expression was confirmed in various organs, with sFAP quantified in both healthy mice and humans. Human studies with [68Ga]Ga-DOTA.SA.FAPI revealed reduced off-target uptake (e.g., pancreas, salivary glands, heart), aligning with the preclinical findings.

Conclusion
The study highlights the crucial need for precise FAPI-radiotracer dosing, optimizing PET imaging, reducing radiation exposure, and enhancing treatment by accounting for FAP biology and sFAP’s influence on pharmacokinetics.
A mathematical model for the investigation of combined treatment of radiopharmaceutical therapy and PARP inhibitors
Authors: Ryhiner Marc , Song Yangmeihui , Hong Jimin , Ferreira Carlos Vinícius Gomes , Rominger Axel , Kossatz Susanne , Glatting Gerhard , Weber Wolfgang , Shi Kuangyu 
Published: February 2025

Abstract

Background
Although the combined treatment with radiopharmaceutical therapy (RPT) and poly (ADP-ribose) polymerase inhibitors (PARPi) shows promise, a critical challenge remains in the limited quantitative understanding needed to optimize treatment protocols. This study introduces a mathematical model that quantitatively represents homologous recombination deficiency (HRD) and facilitates patient-specific customization of therapeutic schedules.

Methods
The model predicts therapeutic outcomes based on the absorbed dose by DNA and the resulting radiobiological responses, with DNA double-strand breaks (DSBs) being the critical determinant of cancer cell fate. The effect of PARPi is modeled by the accelerated conversion of single-strand breaks (SSBs) to DSBs due to PARP-trapping in the S phase, while HRD is represented by defects in DSB repair in replicated DNA. In vitro experiments are used to calibrate the model parameters and validate the model. In silico tests are designed to extensively investigate various combination protocols including the LuPARP trial.

Results
Model calibration was performed using data from the treatment of NCI-H69 cells with [177Lu]Lu-DOTA-TOC and PARPi. Previously published in vivo studies were integrated into the presented model. Model validation using in vitro data showed deviations within the experimental error margins, with average deviations of 5.3 ± 3.2% without PARPi, 6.1 ± 4.4% with Olaparib, and 12 ± 18% with Rucaparib. Rucaparib radiosensitization reduces number of tumor cells during lutetium therapy by 99.2% and 99.99% (HRD). The highest radiosensitizing effect in vivo and in vitro was observed with Talazoparib (IC50: 4.8 nM), followed by Rucaparib (IC50: 1.4 µM). The model predicts relative tumor shrinkage after 14 days of combination treatment with Olaparib (250 mg) based on patient body weight (e.g. 60 kg: 99.6%; 90 kg: 98.0%).

Conclusion
Results demonstrate the potential of this computational model as a step toward the development of the digital twin for systematic exploration and optimization of clinical protocols.
3-year overall survival benefit of systematic follow-up with 18F-FDG PET/CT in asymptomatic patients treated for head and neck squamous cell carcinoma: a multicenter study
Authors: Mahéo C. , Abgral R. , Clément C. , Malard O. , Espitalier F. , Ferron C. , Delcroix O. , Le Pennec R. , Schick U. , Tissot V. , Le Gal G. , Kraeber-Bodéré F. , Eugène T. , Marianowski- R. , Salaün P. Y. , Leclère- Jean-Christophe 
Published: February 2025

Abstract

Purpose
Patients diagnosed with head and neck squamous cell carcinoma (HNSCC) face a significant risk of locoregional recurrence within the first two years after treatment. While early detection of recurrence could potentially improve patient outcomes, the impact of such detection on survival remains uncertain. The aim was to assess the potential benefit of a systematic post-treatment follow-up strategy using 18 F-FDG PET/CT imaging on overall survival.

Methods
In this multicenter case-control study, patients were treated in two health areas from two different regions in France. All adults diagnosed with histologically confirmed HNSCC and treated between January 2017 and December 2020 with curative intent, with a complete response on imaging were included in the study. Primary endpoint was 3-year overall survival. The log-rank test was used to compare 3-year OS rates between the CFU (conventional follow-up) and PET/CT groups. A Cox regression model was used to assess the effect of the addition of 18 F-FDG PET/CT on survival outcomes.

Results
A total of 697 patients were included (534 males [77%], median age[IQR] 62[57–69] years); 508 patients had CFU and 189 patients had CFU + systematic annual 18 F-FDG PET/CT. Cox regression analysis showed a protective effect (OR = 0.56, 95%CI:0.397–0.795, p = 0.001) of systematic 18 F-FDG PET/CT. The 3-year OS in the PET/CT group was better than in the CFU group (83.5 ± 2.8% vs. 73.4 ± 2.1%, p = 0.008). The analysis based on stage showed a significantly better 3-year OS for advanced stage III/IV in the PET/CT group (n = 124) than in the CFU group (n = 312)(79.9 ± 3.7% vs. 71.5 ± 2.7%, p = 0.045) as well as for early stage I/II (90.5 ± 3.7% vs. 76.3 ± 3.2%, p = 0.047).

Conclusion
In this multicenter study, the use of 18 F-FDG PET/CT as an alternative to annual chest CT in the follow-up of head and neck squamous cell carcinoma (HNSCC) is associated to a survival benefit at 3 years.

Clinical trial number
Not applicable (retrospective study).
Neuro-toxoplasmosis in haploidentical haematopoietic stem cell transplant
Authors: Galli Marco , Masina Lorenzo , Magliano Gabriele , Morello Enrico , Van Hauwermeiren Evelyn , Malagola Michele , Farina Mirko , Radici Vera , Russo Domenico , Avenoso Daniele 
Published: February 2025

Abstract
Allogeneic haematopoietic stem cell transplant is a routine procedure for several haematological disorders though infections are the main cause of morbidity and mortality. Rare infections, such as protozoan reactivations, can be life-threatening and clinicians should be aware of these possibilities. Herein, we present a case of neuro-toxoplasmosis post haploidentical haematopoietic stem cell transplant.
Exponential speedup over locality in MPC with optimal memory
Authors: Balliu Alkida , Brandt Sebastian , Fischer Manuela , Latypov Rustam , Maus Yannic , Olivetti Dennis , Uitto Jara 
Published: February 2025

Abstract
Locally Checkable Labeling () problems are graph problems in which a solution is correct if it satisfies some given constraints in the local neighborhood of each node. Example problems in this class include maximal matching, maximal independent set, and colorings. A successful line of research has been studying the complexities of s on paths/cycles, trees, and general graphs, providing many interesting results for the model of distributed computing. In this work, we initiate the study of problems in the low-space Massively Parallel Computation () model. In particular, on forests, we provide a method that, given the complexity of an problem in the model, automatically provides an exponentially faster algorithm for the low-space setting that uses optimal global memory, that is, truly linear. While restricting to forests may seem to weaken the results, we emphasize that all known (conditional) lower bounds for the setting are obtained through lower bounds for problems in the distributed setting in tree-like networks (either trees or high-girth graphs), and hence the problems that we study are challenging already on trees. Moreover, our algorithms use optimal global memory, i.e., memory linear in the number of edges of the graph. In contrast, most of the state-of-the-art algorithms use more than linear global memory. Further, they typically start with a dense graph, sparsify it, and then solve the problem on the residual graph, exploiting the relative increase in global memory. On forests this is not possible, hence using optimal memory requires new solutions.
Marginal adaptation analysis of CAD/CAM resin crown with non-invasive methods
Authors: Zeng Chen , Tabata Tomoko , Takahashi Rena , Ikeda Masaomi , Shinagawa Junichi , Nakagawa Hisaichi , Tsuchida Yumi , Takano Shunsuke , Sumi Yasunori , Shimada Yasushi 
Published: February 2025

Abstract

Objectives
This study compared the silicone replica method with swept-source optical coherence tomography (SS-OCT) to analyze marginal adaptation and investigated the effect of the light incidence angle of SS-OCT on measurement precision.

Materials and methods
A typodont-prepared mandibular right first molar was scanned using an intraoral scanner (Trios 3). Fourteen crowns were fabricated from CAD/CAM resin blocks (Katana Avencia P) using a 5-axis milling machine (DWX-50). Marginal adaptation at the buccal, lingual, mesial, and distal points was assessed using the silicone replica method and SS-OCT at light incidence angles of 60°, 75°, and 90°. Statistical comparisons were performed using two-way analysis of variance (ANOVA) and t-tests with Bonferroni correction, and t-tests at a significance level of 0.05.

Results
At 60°, SS-OCT showed significantly larger marginal discrepancies than the silicone replica method at the buccal, lingual, and mesial points (p < 0.05). At 75°, only the lingual point showed a significantly larger value than the silicone replica method (p < 0.05). At 90°, no significant differences were observed between the SS-OCT and silicone replica methods (p > 0.05). Marginal discrepancy values increased as the angle changed from 90° to 75° to 60°, with significant differences between 60° and 75° and between 60° and 90° at the buccal and lingual points (p < 0.05).

Conclusions
SS-OCT is a viable alternative to the silicone replica method for assessing marginal adaptation at an incidence angle of 90 °.

Clinical relevance
SS-OCT, a non-invasive method, has the potential to be applied clinically for evaluating marginal fit in indirect restorations in vivo.
Neurology and physician-assisted suicide: glossary of definitions and terminology
Authors: Solari Alessandra , Ticozzi Nicola , Comi Giancarlo , Mancardi Gianluigi , Provinciali Leandro , Padovani Alessandro , Pucci Eugenio 
Published: February 2025

Abstract
The progress of biomedical technologies has expanded the boundaries of care, offering new treatment options and prolonging patients’ survival even in conditions of great suffering and dependence. End-of-life decisions are an important topic in contemporay bioethics and physician-assisted suicide (PAS) is a still controversial topic, with Neurology at the forefront.
This glossary provides a set of definitions to improve clarity and use of a consistent language in the bioethical debate on patients’ autonomy, treatment limitations, palliative care, PAS, euthanasia, and related issues. The objective of the glossary, which is aligned with most recent international consensus documents and with the italian regulatory frameworks, is to clarify and harmonize the practical use of terms.
The glossary, together with the companion paper outlining the position of the Italian Society of Neurology (SIN) regarding PAS, are living documents subject to revision. They can serve as a foundation for a pluralistic discussion in the debate on the ethical issues related to the care of individuals with neurological diseases characterized by poor prognosis in terms of severe disability or limited biological and biographical life expectancies, as well as their families and caregivers. An even more ambitious goal of these documents is to enhance research and inform the development of national regulation in these areas.
Cross-border seasonal migrant labour and agricultural commodity production in the Ethiopia–Sudan borderlands
Authors: Moreda Tsegaye 
Published: February 2025

Abstract
The Ethiopia-Sudan borderlands have long been a hub of capitalist production of lucrative agricultural commodities such as sesame that profoundly shape the political economy of these borderlands. Cross-border seasonal migrant labour is central to this capitalist commodity production but is often neglected in discussions, which chiefly focus on economic and geopolitical wranglings between different groups over the control of land and commodity production in these areas. If there is any talk of migrant labour, it is reduced a priori to how these agricultural commodity production sites are crucial in providing employment opportunities to migrant workers and how the flow of such labour should be governed. Thus, the role of migrant labour is rarely recognized, and the associated dynamics of exploitation in its varied manifestations remain obscure. This paper argues that the history and profitability of commodity production in the borderlands are connected to, and rooted in, the availability of vast, cheap, flexible and exploited migrant agricultural labour. This labour is the result of various processes, including land grabs, landlessness, conflict and climate change. The paper argues that the dynamics of exploitation occur not only to seasonal migrants in the capitalist production sites but also to their families and communities back home who shoulder the responsibilities of family subsistence and reproducing the labour of the migrant. The paper contributes to an understanding of the relationship between migrant labour and capitalist commodity production, particularly the crucial role of seasonal migrant labour and the dynamics of exploitation, both in the places of origin and the areas of seasonal migrant work. This will, in turn, contribute to identifying the needs of seasonal migrants and the challenges they face, necessary for informing political struggles for labour justice and socio-economic policies.
Improving the hydrophilic microenvironment surrounding the catalytic site of fructosyltransferase enhances its catalytic ability
Authors: Wang Fanzhi , Singh Suren , Permaul Kugen 
Published: February 2025

Abstract
The hydrophilic microenvironment surrounding an enzyme's active site can influence its catalytic activity. This study examines the effect of enhancing this environment in the Aspergillus niger fructosyltransferase, SucC. Bioinformatics analysis identified a cysteine residue (C66) near the catalytic triad (D64, D194, E271) as vital for maintaining the active site's structure and facilitating substrate transport. Simulated mutagenesis suggested that mutating cysteine to serine (C66S) could increase hydrophilicity without altering the structure significantly. This mutation was predicted to enhance substrate affinity, with binding energy changing from −3.65 to −4.14 kcal mol−1. The C66S mutant, expressed in Pichia pastoris GS115, showed a 61.3% increase in specific activity, a 13.5% decrease in K
m (82.20/71.14 mM), and a 21.6% increase in k
cat (112.23/136.48 min−1), resulting in a 40.1% increase in catalytic efficiency (1.37/1.92 min−1 mM−1). For fructooligosaccharides (FOS) production, C66S demonstrated enhanced transfructosylation, particularly in the initial stages of the reaction, achieving higher overall FOS yields. These findings highlight that modifying the active site hydrophilicity, without causing major structural changes, is a promising strategy for improving an enzyme’s catalytic efficiency.
Augmented Graphical Ridge Estimation with Application in the Cryptocurrency Market
Authors: Bekker A. , Kheyri A. , Arashi M. 
Published: February 2025

Abstract
Cryptocurrency markets exhibit complex and evolving structures, making it challenging to identify appropriate models that can effectively capture their returns, particularly in high-dimensional settings. This paper presents a two-step augmented graphical ridge estimator for precision matrix estimation in Gaussian graphical models. The proposed estimator combines

$$L_1$$

L
1

and Frobenius norm penalties to improve estimation accuracy compared to existing methods. Simulation studies demonstrate its superior performance under various conditions. When applied to thirty cryptocurrencies from 2019 to 2021, the estimator reveals the dynamic interconnections within the market, offering valuable insights into the structure of the cryptocurrency network and dependencies across assets.
Scientific Theory and Possibility
Authors: Baron Sam , Le Bihan Baptiste , Read James 
Published: February 2025

Abstract
It is plausible that the models of scientific theories correspond to possibilities. But how do we know which models of which scientific theories so correspond? This paper provides a novel proposal for guiding belief about possibilities via scientific theories. The proposal draws on the notion of an effective theory: a theory that applies very well to a particular, restricted domain. We argue that it is the models of effective theories that we should believe correspond, at least in part, to possibilities. It is thus effective theories that should guide modal reasoning in science.